FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Armborst, D
   Metzner, C
   Bitterlich, N
   Lemperle, M
   Siener, R
AF Armborst, Deborah
   Metzner, Christine
   Bitterlich, Norman
   Lemperle, Martin
   Siener, Roswitha
TI Effect of a weight-loss stabilization following a weight reduction with
   or without meal replacement on cardiometabolic risk in overweight women.
   A randomized controlled trial
SO INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
LA English
DT Article
DE Weight-loss stabilization; weight reduction; abdominal obesity;
   cardiometabolic risk factors; weight management
ID METABOLICALLY HEALTHY OBESITY; HIGH-DENSITY-LIPOPROTEIN; LIFE-STYLE
   INTERVENTION; FATTY LIVER-DISEASE; HYPERTRIGLYCERIDEMIC-WAIST;
   CARDIOVASCULAR-DISEASE; BLOOD-PRESSURE; DIETARY-INTAKE; MENTAL STRESS;
   HEART-DISEASE
AB The objective of this study was to examine the effect of a 3-month weight-loss-stabilization phase (phase 2) following a successful 3-month weight-loss phase (phase 1), including a conventional energy-restricted diet with (MR) or without (C) meal replacement, on the cardiometabolic risk profile in 80 overweight women. In phase 2, both groups continued to significantly reduce weight and sustained the significant decreases in waist circumference and LDL-C. During the study, folic acid concentration significantly increased in the MR-group, while homocysteine concentration significantly worsened in the C-group. After 6 months, the number of women with hypertriglyceridemic waist was significantly reduced in both the groups, however with metabolic syndrome and metabolically unhealthy abdominal obesity (MUHAO) only in the MR-group. In conclusion, both strategies were equally effective for weight loss and weight-loss stabilization. The micronutrient supplementation with MR seemed to have an additional beneficial impact on the cardiometabolic risk in the MR-group versus the C-group.
C1 [Armborst, Deborah; Siener, Roswitha] Univ Bonn, Dept Urol, Med Nutr Sci, Sigmund Freud Str 25, D-53105 Bonn, Germany.
   [Metzner, Christine] Rhein Westfal TH Aachen, Univ Hosp, Dept Internal Med 3, Aachen, Germany.
   [Metzner, Christine] Bonn Educ Assoc Dietet RA, Cologne, Germany.
   [Bitterlich, Norman] Dept Biostat Med & Serv Ltd, Chemnitz, Germany.
   [Lemperle, Martin] Outpatient Ctr Nutr Educ, Frankfurt, Germany.
C3 University of Bonn; RWTH Aachen University; RWTH Aachen University
   Hospital
RP Armborst, D (corresponding author), Univ Bonn, Dept Urol, Med Nutr Sci, Sigmund Freud Str 25, D-53105 Bonn, Germany.
EM s7dearmb@uni-bonn.de
FU FormMed HealthCare AG, Frankfurt, Germany
FX The meal replacement products were provided free of charge from FormMed
   HealthCare AG, Frankfurt, Germany, which supported this work in part by
   a research grant.
CR Adam TC, 2007, PHYSIOL BEHAV, V91, P449, DOI 10.1016/j.physbeh.2007.04.011
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alkhatib B., 2018, CURR MOL BIOL REP, P1
   Arsenault BJ, 2010, CAN MED ASSOC J, V182, P1427, DOI 10.1503/cmaj.091276
   Ashley JM, 2007, NUTR J, V6, DOI 10.1186/1475-2891-6-12
   Ashwell M, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2015-010159
   Bedogni G, 2006, BMC GASTROENTEROL, V6, DOI 10.1186/1471-230X-6-33
   Byrne CD, 2015, J HEPATOL, V62, pS47, DOI 10.1016/j.jhep.2014.12.012
   Chaiyasoot K, 2018, NUTR DIABETES, V8, DOI 10.1038/s41387-018-0034-0
   Cook CM, 2017, FRONT NUTR, V4, DOI 10.3389/fnut.2017.00055
   Damms-Machado A, 2012, NUTR J, V11, DOI 10.1186/1475-2891-11-34
   Davis LM, 2010, NUTR J, V9, DOI 10.1186/1475-2891-9-11
   De Ycaza AEE, 2018, INT J OBESITY, V42, P302, DOI 10.1038/ijo.2017.233
   Dhonukshe-Rutten RAM, 2009, EUR J CLIN NUTR, V63, P18, DOI 10.1038/sj.ejcn.1602897
   Elder CR, 2012, INT J OBESITY, V36, P86, DOI 10.1038/ijo.2011.60
   Fitzpatrick SL, 2016, AM J MED, V129, DOI 10.1016/j.amjmed.2015.07.015
   Fothergill E, 2016, OBESITY, V24, P1612, DOI 10.1002/oby.21538
   Frankenfield DC, 1998, J AM DIET ASSOC, V98, P439, DOI 10.1016/S0002-8223(98)00100-X
   Ganguly P, 2015, NUTR J, V14, DOI 10.1186/1475-2891-14-6
   Gasevic D, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-38
   Gebler L., 2015, J Obes Weight Loss Ther, V5, P2
   Geiker NRW, 2018, NUTR METAB, V15, DOI 10.1186/s12986-018-0263-1
   German Nutrition Society. Federal Ministry of Food Agriculture and Consumer Protection, 2012, NUTR REP 2012 SUMM
   Ghiadoni L, 2000, CIRCULATION, V102, P2473, DOI 10.1161/01.CIR.102.20.2473
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Guo FJ, 2016, OBESITY, V24, P516, DOI 10.1002/oby.21344
   Hamer M, 2012, J CLIN ENDOCR METAB, V97, P2482, DOI 10.1210/jc.2011-3475
   Hamer M, 2012, J CLIN ENDOCR METAB, V97, pE29, DOI 10.1210/jc.2011-2132
   Heymsfield SB, 2003, INT J OBESITY, V27, P537, DOI 10.1038/sj.ijo.0802258
   Heymsfield SB, 2010, PHYSIOL BEHAV, V100, P90, DOI 10.1016/j.physbeh.2010.02.010
   Hinnouho GM, 2015, EUR HEART J, V36, P551, DOI 10.1093/eurheartj/ehu123
   Hinnouho GM, 2013, DIABETES CARE, V36, P2294, DOI 10.2337/dc12-1654
   Jakicic JM, 2016, JAMA-J AM MED ASSOC, V316, P1161, DOI 10.1001/jama.2016.12858
   Jung CH, 2017, KOREAN J INTERN MED, V32, P611, DOI 10.3904/kjim.2016.259
   Kahathuduwa CN, 2018, APPETITE, V120, P431, DOI 10.1016/j.appet.2017.09.025
   Kahn HS, 2003, AM J CLIN NUTR, V78, P928, DOI 10.1093/ajcn/78.5.928
   Kimmons Joel E, 2006, MedGenMed, V8, P59
   König D, 2015, NUTRIENTS, V7, P9825, DOI 10.3390/nu7125500
   Kruschitz R, 2017, OBESITY FACTS, V10, P76, DOI 10.1159/000454836
   Kusano C., 2008, J of Cell and Mol Biol, V7, P1
   Langendonk JG, 2006, EUR J INTERN MED, V17, P465, DOI 10.1016/j.ejim.2006.04.011
   Lean MEJ, 2018, LANCET, V391, P541, DOI 10.1016/S0140-6736(17)33102-1
   Lemieux I, 2001, ARCH INTERN MED, V161, P2685, DOI 10.1001/archinte.161.22.2685
   Lemieux I, 2000, CIRCULATION, V102, P179, DOI 10.1161/01.CIR.102.2.179
   Lemieux I, 2007, CAN J CARDIOL, V23, p23B, DOI 10.1016/S0828-282X(07)71007-3
   Li JC, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-09522-5
   Lonardo A, 2015, DIGEST LIVER DIS, V47, P181, DOI 10.1016/j.dld.2014.09.020
   Lopes HF, 2003, HYPERTENSION, V41, P422, DOI 10.1161/01.HYP.0000053450.19998.11
   MacLean PS, 2011, AM J PHYSIOL-REG I, V301, pR581, DOI 10.1152/ajpregu.00755.2010
   Magkos F, 2016, CELL METAB, V23, P591, DOI 10.1016/j.cmet.2016.02.005
   Mason Jennifer E, 2010, Prev Cardiol, V13, P36, DOI 10.1111/j.1751-7141.2009.00054.x
   McEwen BS, 2007, PHYSIOL REV, V87, P873, DOI 10.1152/physrev.00041.2006
   Metzner CE, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-64
   Mozaffarian D, 2016, CIRCULATION, V133, pE38, DOI 10.1161/CIR.0000000000000350
   Nackers LM, 2010, INT J BEHAV MED, V17, P161, DOI 10.1007/s12529-010-9092-y
   Nakazato M, 2011, EUR J NUTR, V50, P581, DOI 10.1007/s00394-010-0165-0
   Neter JE, 2003, HYPERTENSION, V42, P878, DOI 10.1161/01.HYP.0000094221.86888.AE
   Noakes M, 2004, J NUTR, V134, P1894, DOI 10.1093/jn/134.8.1894
   Nseir W, 2014, WORLD J GASTROENTERO, V20, P9338, DOI 10.3748/wjg.v20.i28.9338
   O'Shaughnessy KM, 2004, J CLIN INVEST, V113, P1075, DOI 10.1172/JCI200421560
   Ortega FB, 2013, EUR HEART J, V34, P390, DOI 10.1093/eurheartj/ehs174
   Rolland C, 2011, CHOLESTEROL, DOI 10.1155/2011/306278
   Roussell MA, 2007, J CLIN LIPIDOL, V1, P65, DOI 10.1016/j.jacl.2007.02.005
   Ruttmann E, 2005, CIRCULATION, V112, P2130, DOI 10.1161/CIRCULATIONAHA.105.552547
   Savva SC, 2013, DIABET METAB SYND OB, V6, P403, DOI 10.2147/DMSO.S34220
   Poli VFS, 2017, NUTRITION, V38, P113, DOI 10.1016/j.nut.2017.01.012
   Shikany JM, 2013, INT J OBESITY, V37, P1571, DOI 10.1038/ijo.2013.43
   Skovierová H, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17101733
   Sofi F, 2014, WORLD J GASTROENTERO, V20, P7339, DOI 10.3748/wjg.v20.i23.7339
   Soleymani T, 2016, OBES REV, V17, P81, DOI 10.1111/obr.12322
   Stelmach-Mardas M, 2014, P NUTR SOC, V73, P509, DOI 10.1017/S0029665114000718
   Tchernof A, 2013, PHYSIOL REV, V93, P359, DOI 10.1152/physrev.00033.2011
   Toth PP, 2005, AM J CARDIOL, V96, p50K, DOI 10.1016/j.amjcard.2005.08.008
   Troesch B, 2012, BRIT J NUTR, V108, P692, DOI 10.1017/S0007114512001808
   Van Gaal LF, 2005, EUR HEART J SUPPL, V7, pL21, DOI 10.1093/eurheartj/sui082
   Velho S, 2010, EUR J CLIN NUTR, V64, P1043, DOI 10.1038/ejcn.2010.114
   Via Michael, 2012, ISRN Endocrinol, V2012, P103472, DOI 10.5402/2012/103472
   Whitworth Judith A, 2005, Vasc Health Risk Manag, V1, P291, DOI 10.2147/vhrm.2005.1.4.291
   Wing RR, 2011, DIABETES CARE, V34, P1481, DOI 10.2337/dc10-2415
   Woodside JV, 2005, P NUTR SOC, V64, P543, DOI 10.1079/PNS2005464
   Yau YHC, 2013, MINERVA ENDOCRINOL, V38, P255
NR 82
TC 5
Z9 5
U1 0
U2 12
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-7486
EI 1465-3478
J9 INT J FOOD SCI NUTR
JI Int. J. Food Sci. Nutr.
PD MAY 19
PY 2019
VL 70
IS 4
BP 453
EP 466
DI 10.1080/09637486.2018.1537363
PG 14
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA HW1JG
UT WOS:000466438600009
PM 30621476
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Chuang, JC
   Cui, HX
   Mason, BL
   Mahgoub, M
   Bookout, AL
   Yu, HG
   Perello, M
   Elmquist, JK
   Repa, JJ
   Zigman, JM
   Lutter, M
AF Chuang, Jen-Chieh
   Cui, Huxing
   Mason, Brittany L.
   Mahgoub, Melissa
   Bookout, Angie L.
   Yu, Hana G.
   Perello, Mario
   Elmquist, Joel K.
   Repa, Joyce J.
   Zigman, Jeffrey M.
   Lutter, Michael
TI Chronic social defeat stress disrupts regulation of lipid synthesis
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE anxiety; cholesterol; depression feeding; liver
ID METABOLIC SYNDROME; LIPOPROTEIN RECEPTOR; LDL-RECEPTOR; MAJOR
   DEPRESSION; EXCESS MORTALITY; MOUSE-LIVER; CHOLESTEROL; DISORDER;
   PROTEIN; EXPRESSION
AB Several psychiatric disorders increase the risk of cardiovascular disease, including posttraumatic stress disorder and major depression. While the precise mechanism for this association has not yet been established, it has been shown that certain disorders promote an unfavorable lipid profile. To study the interaction of stress and lipid dysregulation, we utilized chronic social defeat stress (CSDS), a mouse model of chronic stress with features of posttraumatic stress disorder and major depression. Following exposure to CSDS, mice were given access to either regular chow or a Western-style diet high in fat and cholesterol (HFD). The combination of social stress and HFD resulted in significant perturbations in lipid regulation, including two key features of the metabolic syndrome: increased plasma levels of non-HDL cholesterol and intrahepatic accumulation of triglycerides. These effects were accompanied by a number of changes in the expression of hepatic genes involved in lipid regulation. Transcriptional activity of LXR, SREBP1c, and ChREBP were significantly affected by exposure to HFD and CSDS. We present CSDS as a model of social stress induced lipid dysregulation and propose that social stress alters lipid metabolism by increasing transcriptional activity of genes involved in lipid synthesis.-Chuang, J-C., H. Cui, B. L. Mason, M. Mahgoub, A. L. Bookout, H. G. Yu, M. Perello, J. K. Elmquist, J. J. Repa, J. M. Zigman, and M. Lutter. Chronic social defeat stress disrupts regulation of lipid synthesis. J. Lipid Res. 2010. 51: 1344-1353.
C1 [Chuang, Jen-Chieh; Cui, Huxing; Bookout, Angie L.; Perello, Mario; Elmquist, Joel K.; Repa, Joyce J.; Zigman, Jeffrey M.; Lutter, Michael] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Div Hypothalam Res, Dallas, TX 75390 USA.
   [Cui, Huxing; Mason, Brittany L.; Mahgoub, Melissa; Yu, Hana G.; Elmquist, Joel K.; Zigman, Jeffrey M.; Lutter, Michael] Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA.
   [Repa, Joyce J.] Univ Texas SW Med Ctr Dallas, Dept Physiol, Dallas, TX 75390 USA.
   [Bookout, Angie L.; Elmquist, Joel K.] Univ Texas SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center Dallas; University of Texas System; University of Texas
   Southwestern Medical Center Dallas; University of Texas System;
   University of Texas Southwestern Medical Center Dallas; University of
   Texas System; University of Texas Southwestern Medical Center Dallas
RP Lutter, M (corresponding author), Univ Texas SW Med Ctr Dallas, Dept Internal Med, Div Hypothalam Res, Dallas, TX 75390 USA.
EM Michael.Lutter@UTSouthwestern.edu
RI Mason, Brittany/AAN-6360-2021
OI Zigman, Jeffrey/0000-0003-3477-1295; Repa, Joyce/0000-0001-5740-1954;
   Mason, Brittany/0000-0003-1832-1104; Cui, Huxing/0000-0002-8627-8534
FU NARSAD; Physician Scientist Training Program; Disease Oriented Clinical
   Scholars Program; Klarman Family Foundation;  [K08 MH084058-1A1]; 
   [1RL1DK081185-01];  [1PL1DK081182-01];  [8-UL1-DE019584-02];  [R37
   DK53301];  [R01DK071320];  [RL1 DK081182];  [UL1 RR024923];  [RL1
   DK081185];  [K08 DK068069-01A2]
FX This work was supported by the following grants: K08 MH084058-1A1,
   1RL1DK081185-01, 1PL1DK081182-01, 8-UL1-DE019584-02, R37 DK53301;
   R01DK071320, RL1 DK081182, UL1 RR024923, RL1 DK081185, K08
   DK068069-01A2; the NARSAD Young Investigator Award; the Physician
   Scientist Training Program; the Disease Oriented Clinical Scholars
   Program; and the Klarman Family Foundation. Its contents are solely the
   responsibility of the authors and do not necessarily represent the
   official views of the National Institutes of Health or other granting
   agencies.
CR ALLGULANDER C, 1994, ARCH GEN PSYCHIAT, V51, P708
   Avgustinovich DF, 1997, PHYSIOL BEHAV, V61, P37, DOI 10.1016/S0031-9384(96)00303-4
   Berton O, 2006, SCIENCE, V311, P864, DOI 10.1126/science.1120972
   Boscarino JA, 2008, PSYCHOSOM MED, V70, P668, DOI 10.1097/PSY.0b013e31817bccaf
   Caspi L, 2007, CELL METAB, V6, P99, DOI 10.1016/j.cmet.2007.07.005
   Cha JY, 2007, J BIOL CHEM, V282, P743, DOI 10.1074/jbc.M605023200
   Chuang JC, 2010, BIOL PSYCHIAT, V67, P1075, DOI 10.1016/j.biopsych.2009.12.003
   CORYELL W, 1982, ARCH GEN PSYCHIAT, V39, P701
   DAVIES SM, 2009, J PSYCHOPHA IN PRESS
   DESHAIES Y, 1993, HORM METAB RES, V25, P13, DOI 10.1055/s-2007-1002036
   Engelking LJ, 2004, J CLIN INVEST, V113, P1168, DOI 10.1172/JCI200420978
   Erraji-Benchekroun L, 2005, AM J PHYSIOL-ENDOC M, V288, pE715, DOI 10.1152/ajpendo.00113.2004
   Fabbrini E, 2009, P NATL ACAD SCI USA, V106, P15430, DOI 10.1073/pnas.0904944106
   Frank-Kamenetsky M, 2008, P NATL ACAD SCI USA, V105, P11915, DOI 10.1073/pnas.0805434105
   Ghia JE, 2008, J CLIN INVEST, V118, P2209, DOI 10.1172/JCI32849
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Harris EC, 1998, BRIT J PSYCHIAT, V173, P11, DOI 10.1192/bjp.173.1.11
   Heiskanen TH, 2006, J CLIN PSYCHIAT, V67, P1422, DOI 10.4088/JCP.v67n0913
   Heppner PS, 2009, BMC MED, V7, DOI 10.1186/1741-7015-7-1
   HERSHOCK D, 1989, LIFE SCI, V45, P157, DOI 10.1016/0024-3205(89)90290-7
   HERZ J, 1988, EMBO J, V7, P4119, DOI 10.1002/j.1460-2075.1988.tb03306.x
   HIROSE H, 1992, ACTA ENDOCRINOL-COP, V127, P279, DOI 10.1530/acta.0.1270279
   Horton JD, 2002, J CLIN INVEST, V109, P1125, DOI 10.1172/JCI200215593
   Huang BL, 2002, DIABETES, V51, P276, DOI 10.2337/diabetes.51.2.276
   Keeney AJ, 2001, PHYSIOL BEHAV, V74, P177, DOI 10.1016/S0031-9384(01)00541-8
   Krishnan V, 2008, AM J PSYCHIAT, V165, P1109, DOI 10.1176/appi.ajp.2008.08071076
   Kurrasch DM, 2004, METHOD ENZYMOL, V389, P3
   Lutter M, 2008, NAT NEUROSCI, V11, P752, DOI 10.1038/nn.2139
   Lutter M, 2008, J NEUROSCI, V28, P3071, DOI 10.1523/JNEUROSCI.5584-07.2008
   McNutt MC, 2009, J BIOL CHEM, V284, P10561, DOI 10.1074/jbc.M808802200
   Park SW, 2004, J BIOL CHEM, V279, P50630, DOI 10.1074/jbc.M410077200
   RUSSELL DW, 1984, CELL, V37, P577, DOI 10.1016/0092-8674(84)90388-X
   Schmittgen TD, 2008, NAT PROTOC, V3, P1101, DOI 10.1038/nprot.2008.73
   Sgoifo A, 1999, NEUROSCI BIOBEHAV R, V23, P915, DOI 10.1016/S0149-7634(99)00025-1
   Takahashi A, 1996, J AUTONOM NERV SYST, V61, P181, DOI 10.1016/S0165-1838(96)00082-3
   Tontonoz P, 2003, MOL ENDOCRINOL, V17, P985, DOI 10.1210/me.2003-0061
   Unger RH, 2002, ANNU REV MED, V53, P319, DOI 10.1146/annurev.med.53.082901.104057
   Wang PYT, 2008, NATURE, V452, P1012, DOI 10.1038/nature06852
   Yehuda R, 1996, BIOL PSYCHIAT, V40, P79, DOI 10.1016/0006-3223(95)00451-3
   Zelcer N, 2009, SCIENCE, V325, P100, DOI 10.1126/science.1168974
NR 41
TC 97
Z9 107
U1 0
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD JUN
PY 2010
VL 51
IS 6
BP 1344
EP 1353
DI 10.1194/jlr.M002196
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 594UP
UT WOS:000277564700009
PM 20129912
OA Green Published
DA 2025-06-11
ER

PT J
AU Rashidkhani, B
   Gargari, BP
   Ranjbar, F
   Zareiy, S
   Kargarnovin, Z
AF Rashidkhani, Bahram
   Gargari, Bahram Pourghassem
   Ranjbar, Fatemeh
   Zareiy, Sanaz
   Kargarnovin, Zahra
TI Dietary patterns and anthropometric indices among Iranian women with
   major depressive disorder
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Nutrition; Factor analysis; Weight; Body Mass Index
ID BODY-MASS INDEX; METABOLIC SYNDROME; JOLLY FAT; ASSOCIATION; OBESITY;
   SYMPTOMS; PREVALENCE; OVERWEIGHT; RISK; FISH
AB Major depression is a common mental disorder among women. A number of studies have demonstrated the association between some nutrients and food items with depression, but the studies on the association of dietary patterns with depression, especially in the Middle East, are rare. Further, the literature examining the relationship between anthropometric status and depression are inconsistent. In this study, 45 women with major depression and 90 patients with no mental disorder participated. We collected dietary intakes by a semi-quantitative food frequency questionnaire, and measured anthropometric indices (weight, height, waist and hip circumferences). Using factor analysis, two major dietary patterns were extracted: Healthy and Unhealthy. After adjusting for confounders, individuals who gained higher scores in healthy dietary pattern, had 84% lower odds of major depression; while the odds of major depression in participants who gained higher scores in unhealthy dietary pattern showed no significant association. No significant association was found between anthropometric indices and major depression. These results suggest that the healthy dietary pattern is significantly associated with lower odds of major depression in adult women. Further researches are needed to confirm these findings. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
C1 [Rashidkhani, Bahram; Zareiy, Sanaz; Kargarnovin, Zahra] Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, Dept Community Nutr, Tehran, Iran.
   [Gargari, Bahram Pourghassem] Tabriz Univ Med Sci, Fac Hlth & Nutr, Nutr Res Ctr, Dept Biochem & Diet Therapy, Tabriz, Iran.
   [Ranjbar, Fatemeh] Tabriz Univ Med Sci, Dept Psychiat, Fac Med, Tabriz, Iran.
C3 Shahid Beheshti University Medical Sciences; Tabriz University of
   Medical Science; Tabriz University of Medical Science
RP Kargarnovin, Z (corresponding author), Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, Dept Community Nutr, Tehran, Iran.
EM zknovin@hotmail.com
RI rashidkhani, bahram/ABG-9304-2021; Ranjbar, Fatemeh/AAN-9550-2020;
   Pourghassem Gargari, Bahram/D-3556-2017
OI Pourghassem Gargari, Bahram/0000-0001-7667-099X
FU National Nutrition and Food Technology Research Institute (NNFTRI) of
   Iran
FX The present study was supported by a grant from the National Nutrition
   and Food Technology Research Institute (NNFTRI) of Iran, and we are
   grateful for their help. The authors appreciate Dr. Hadi Tabibi for his
   valuable help in designing the study.
CR Akbaraly TN, 2009, BRIT J PSYCHIAT, V195, P408, DOI 10.1192/bjp.bp.108.058925
   [Anonymous], INT J SPORT SOC
   [Anonymous], MED J TABRIZ U MED S
   [Anonymous], 2007, J SCI RES PSYCHOL
   Appleton KM, 2007, J AFFECT DISORDERS, V104, P217, DOI 10.1016/j.jad.2007.03.012
   Azadbakht L, 2005, AM J CLIN NUTR, V82, P523, DOI 10.1093/ajcn/82.3.523
   Belmaker RH, 2008, NEW ENGL J MED, V358, P55, DOI [10.1056/NEJMra073096, 10.1038/nrdp.2016.65]
   Bjerkeset O, 2008, AM J EPIDEMIOL, V167, P193, DOI 10.1093/aje/kwm280
   CRISP AH, 1976, BRIT MED J, V1, P7, DOI 10.1136/bmj.1.6000.7
   Dastgiri S, 2006, PUBLIC HEALTH NUTR, V9, P996, DOI 10.1017/PHN2006982
   Dixon JB, 2003, ARCH INTERN MED, V163, P2058, DOI 10.1001/archinte.163.17.2058
   Eby GA, 2010, MED HYPOTHESES, V74, P649, DOI 10.1016/j.mehy.2009.10.051
   Eskandari F, 2005, METABOLISM, V54, P918, DOI 10.1016/j.metabol.2005.02.006
   Esmaillzadeh A, 2007, AM J CLIN NUTR, V85, P910, DOI 10.1093/ajcn/85.3.910
   Ghassemzadeh H, 2005, DEPRESS ANXIETY, V21, P185, DOI 10.1002/da.20070
   Hajizadeh B, 2010, PUBLIC HEALTH NUTR, V13, P1107, DOI 10.1017/S1368980010000145
   HALLSTROM T, 1981, J PSYCHOSOM RES, V25, P75, DOI 10.1016/0022-3999(81)90093-3
   Hamidifard S, 2009, PSYCHIAT RES, V169, P253, DOI 10.1016/j.psychres.2008.06.033
   Hoogendijk WJG, 2008, ARCH GEN PSYCHIAT, V65, P508, DOI 10.1001/archpsyc.65.5.508
   Jacka FN, 2010, AM J PSYCHIAT, V167, P305, DOI 10.1176/appi.ajp.2009.09060881
   Judd LL, 1996, AM J PSYCHIAT, V153, P1411
   Kaplan BJ, 2007, PSYCHOL BULL, V133, P747, DOI 10.1037/0033-2909.133.5.747
   Kaur C, 2001, INT J FOOD SCI TECH, V36, P703, DOI 10.1046/j.1365-2621.2001.00513.x
   Kelishadi R, 2007, B WORLD HEALTH ORGAN, V85, P19, DOI 10.2471/BLT.06.030783
   Kennedy Sidney H, 2008, Dialogues Clin Neurosci, V10, P271
   KESSLER RC, 1993, J AFFECT DISORDERS, V29, P85, DOI 10.1016/0165-0327(93)90026-G
   Lampe JW, 1999, AM J CLIN NUTR, V70, p475S, DOI 10.1093/ajcn/70.3.475s
   Logan Alan C, 2004, Lipids Health Dis, V3, P25
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Messina MJ, 1999, AM J CLIN NUTR, V70, p439S, DOI 10.1093/ajcn/70.3.439s
   Mohammadi Mohammad-Reza, 2005, Clin Pract Epidemiol Ment Health, V1, P16, DOI 10.1186/1745-0179-1-16
   Murray CJL, 1997, LANCET, V349, P1498, DOI 10.1016/S0140-6736(96)07492-2
   Nanri A, 2010, EUR J CLIN NUTR, V64, P832, DOI 10.1038/ejcn.2010.86
   Nourbala A., 2009, Hakim Res J, V11, P47
   Oddy WH, 2009, PREV MED, V49, P39, DOI 10.1016/j.ypmed.2009.05.009
   Palinkas LA, 1996, J PSYCHOSOM RES, V40, P59, DOI 10.1016/0022-3999(95)00542-0
   Poirier P, 2006, ARTERIOSCL THROM VAS, V26, P968, DOI 10.1161/01.ATV.0000216787.85457.f3
   Rezazadeh A, 2010, ARYA ATHEROSCLER, V6, P23
   Roberts RE, 2003, INT J OBESITY, V27, P514, DOI 10.1038/sj.ijo.0802204
   ROSS CE, 1994, J HEALTH SOC BEHAV, V35, P63, DOI 10.2307/2137335
   Sánchez-Villegas A, 2009, ARCH GEN PSYCHIAT, V66, P1090, DOI 10.1001/archgenpsychiatry.2009.129
   Sharifi V, 2009, COMPR PSYCHIAT, V50, P86, DOI 10.1016/j.comppsych.2008.04.004
   Sidhu KS, 2003, REGUL TOXICOL PHARM, V38, P336, DOI 10.1016/j.yrtph.2003.07.002
   Sontrop J, 2006, PREV MED, V42, P4, DOI 10.1016/j.ypmed.2005.11.005
   Strom M, 2009, AM J CLIN NUTR, V90, P149, DOI 10.3945/ajcn.2009.27552
   Tassabehji NM, 2008, PHYSIOL BEHAV, V95, P365, DOI 10.1016/j.physbeh.2008.06.017
   van Staveren WA, 2008, J AM COLL NUTR, V27, p747S, DOI 10.1080/07315724.2008.10719753
   WEISSENBURGER J, 1986, PSYCHIAT RES, V17, P275, DOI 10.1016/0165-1781(86)90075-2
   Williams AL, 2005, FAM PRACT, V22, P532, DOI 10.1093/fampra/cmi040
   Zisook S, 2004, PSYCHIAT RES, V129, P127, DOI 10.1016/j.psychres.2004.07.004
NR 50
TC 38
Z9 41
U1 0
U2 11
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD NOV 30
PY 2013
VL 210
IS 1
BP 115
EP 120
DI 10.1016/j.psychres.2013.05.022
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 250NL
UT WOS:000326859400018
PM 23806625
DA 2025-06-11
ER

PT J
AU Zák, A
   Tvrzická, E
   Vecka, M
   Jáchymova, M
   Duffková, L
   Stanková, B
   Vávrová, L
   Kodydková, J
   Zeman, M
AF Zak, Ale
   Tvrzicka, Eva
   Vecka, Marek
   Jachymova, Marie
   Duffkova, Ladislava
   Stankova, Barbora
   Vavrova, Lucie
   Kodydkova, Jana
   Zeman, Miroslev
TI Severity of metabolic syndrome unfavorably influences oxidative stress
   and fatty acid metabolism in men
SO TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
LA English
DT Article
DE metabolic syndrome components; fatty acid composition; oxidative stress
ID INSULIN-RESISTANCE SYNDROME; CARDIOVASCULAR RISK-FACTORS; FASTING
   PLASMA-GLUCOSE; BETA-CELL FUNCTION; MIDDLE-AGED MEN; APOLIPOPROTEIN-E;
   SERUM-LIPIDS; DIETARY-FAT; DENSITY-LIPOPROTEIN; BINDING PROTEIN
AB Metabolic syndrome (MS) is defined by the clustering of several components (MSC), which include abdominal fat accumulation, impaired glucose homeostasis, hypertriglyceridemia, lowered high-density lipoprotein cholesterol, increased blood pressure, and hyperuricemia. Metabolic syndrome is also accompanied by increased oxidative stress and inflammation as well as by altered composition of esterified fatty acids (FA). Therefore, we have investigated 210 men (categorized into six groups with increasing number of MSC) to find trends in the extent of oxidative stress, FA pattern and frequency of pathological alleles of the selected candidate genes for lipid metabolism. Increasing number of MSC was connected with the raised serum glucose and insulin, increased concentrations of conjugated dienes in low-density lipoprotein (all p < 0.0001), and high frequency of e2 and e4 alleles of the apolipoprotein E gene (p < 0.005). However, the last significance was lost after the adjustment for age. The incidence of 54Thr allele for intestinal isoform of the fatty acid-binding protein (FABP-2) gene was comparable in all groups. The most important findings were the raised content of saturated FA and the increased activities of Delta 9 and Delta 6 desaturases (all p < 0.0001), and the decreased content of polyunsaturated FA n-6 family and the decreased activity of A 5 desaturase (both p < 0.001) in connection with increasing number of MSC. In conclusion, the severity of MS is connected with the progression of oxidative stress and the unfavorable changes in the FA composition. These changes are independent of the studied gene polymorphisms.
C1 Charles Univ Prague, Dept Internal Med 4, Fac Med 1, Prague, Czech Republic.
   Charles Univ Prague, Inst Clin Biochem & Lab Diagnost, Fac Med 1, Prague, Czech Republic.
C3 Charles University Prague; Charles University Prague
RP Zák, A (corresponding author), Dept Med 4, U Nemocnice 2, Prague 12808 2, Czech Republic.
EM azak@vfn.cz
RI Vavrova, Lucie/D-7030-2017; Zak, Ales/G-8318-2016; Rychlikova,
   Jana/A-2531-2015; Vecka, Marek/A-3560-2008; Tvrzicka, Eva/Q-6300-2016;
   Zeman, Miroslav/J-5281-2016; Stankova, Barbora/L-7933-2016
OI Zak, Ales/0000-0002-1698-6068; Rychlikova, Jana/0000-0002-6961-5260;
   Vecka, Marek/0000-0002-3269-1817; Tvrzicka, Eva/0000-0003-0794-8454;
   Zeman, Miroslav/0000-0001-5338-603X; Stankova,
   Barbora/0000-0002-6184-4878
CR Aarsland A, 1997, AM J CLIN NUTR, V65, P1774, DOI 10.1093/ajcn/65.6.1774
   Ahotupa M, 1996, CLIN BIOCHEM, V29, P139, DOI 10.1016/0009-9120(95)02043-8
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   AUSTIN MA, 1995, INT J OBESITY, V19, pS22
   Avramoglu RK, 2006, CLIN CHIM ACTA, V368, P1, DOI 10.1016/j.cca.2005.12.026
   Bergeron N, 1996, J CLIN INVEST, V97, P65, DOI 10.1172/JCI118408
   Campos H, 2001, GENET EPIDEMIOL, V20, P117, DOI 10.1002/1098-2272(200101)20:1<117::AID-GEPI10>3.0.CO;2-C
   Carpentier YA, 2006, AM J CLIN NUTR, V83, p1499S, DOI 10.1093/ajcn/83.6.1499S
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Chan DC, 2006, CURR OPIN LIPIDOL, V17, P28, DOI 10.1097/01.mol.0000199815.46720.ca
   Cohn GS, 2005, AM J HYPERTENS, V18, P1099, DOI 10.1016/j.amjhyper.2005.02.004
   Cushman M, 2005, CIRCULATION, V112, P25, DOI 10.1161/CIRCULATIONAHA.104.504159
   Damcott CM, 2003, HUM GENET, V112, P610, DOI 10.1007/s00439-003-0937-1
   Decsi T, 2000, LIPIDS, V35, P1179, DOI 10.1007/s11745-000-0634-7
   DIXON WJ, 1992, BMDP STAT SOFTWARE M, V1
   DUNIN JVG, 1974, BR J NUTR, V32, P77
   EDWARDS KL, 1994, ARTERIOSCLER THROMB, V14, P1940, DOI 10.1161/01.ATV.14.12.1940
   Erkkilä AT, 2001, AM J CLIN NUTR, V73, P746
   Fernández-Miranda C, 2001, NUTRITION, V17, P529, DOI 10.1016/S0899-9007(01)00552-4
   Fujita K, 2006, CIRC J, V70, P1437, DOI 10.1253/circj.70.1437
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Greenberg AS, 2002, EUR J CLIN INVEST, V32, P24, DOI 10.1046/j.1365-2362.32.s3.4.x
   Grundy SM, 2006, NAT REV DRUG DISCOV, V5, P294, DOI 10.1038/nrd2005
   HIXSON JE, 1990, J LIPID RES, V31, P545
   HOLMAN RT, 1995, J NUTR, V125, P901
   Ishii T, 2001, METABOLISM, V50, P1301, DOI 10.1053/meta.2001.27228
   Jáchymová M, 2001, BIOCHEM BIOPH RES CO, V284, P426, DOI 10.1006/bbrc.2001.5007
   Klein-Platat C, 2005, AM J CLIN NUTR, V82, P1178, DOI 10.1093/ajcn/82.6.1178
   Laakso M, 2004, CURR OPIN LIPIDOL, V15, P115, DOI 10.1097/00041433-200404000-00004
   Laaksonen DE, 2002, DIABETIC MED, V19, P456, DOI 10.1046/j.1464-5491.2002.00707.x
   Lahoz C, 2001, ATHEROSCLEROSIS, V154, P529, DOI 10.1016/S0021-9150(00)00570-0
   Leskinen MH, 2005, SCAND J CLIN LAB INV, V65, P485, DOI 10.1080/00365510510025836
   Levy E, 2001, J BIOL CHEM, V276, P39679, DOI 10.1074/jbc.M105713200
   Lindgärde F, 2006, AM J CLIN NUTR, V84, P1009, DOI 10.1093/ajcn/84.5.1009
   LOCHMAN T, 1989, STANDARDIZATION ANTH, P39
   Loevinger BL, 2007, METABOLISM, V56, P87, DOI 10.1016/j.metabol.2006.09.001
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   MILLER SA, 1988, NUCLEIC ACIDS RES, V16, P1215, DOI 10.1093/nar/16.3.1215
   Miranda PJ, 2005, AM HEART J, V149, P33, DOI 10.1016/j.ahj.2004.07.013
   Nesto Richard W, 2003, Rev Cardiovasc Med, V4 Suppl 6, pS11
   OHARA Y, 1993, J CLIN INVEST, V91, P2546, DOI 10.1172/JCI116491
   Okada T, 2006, J ATHEROSCLER THROMB, V13, P192, DOI 10.5551/jat.13.192
   Park SH, 2005, CLIN SCI, V108, P553, DOI 10.1042/CS20040331
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Reiber I, 2003, J NUTR BIOCHEM, V14, P394, DOI 10.1016/S0955-2863(03)00061-5
   Renner W, 2004, ATHEROSCLEROSIS, V173, P137, DOI 10.1016/j.atherosclerosis.2003.11.018
   Retnakaran R, 2006, J PEDIATR-US, V148, P176, DOI 10.1016/j.jpeds.2005.08.025
   Riccardi G, 2004, CLIN NUTR, V23, P447, DOI 10.1016/j.clnu.2004.02.006
   Sattar N, 2004, CIRCULATION, V110, P2687, DOI 10.1161/01.CIR.0000145660.60487.94
   SCHUMAKER VN, 1986, METHOD ENZYMOL, V128, P155
   Simopoulos AP, 2003, WORLD REV NUTR DIET, V92, P1
   Sjogren P, 2005, ARTERIOSCL THROM VAS, V25, P2580, DOI 10.1161/01.ATV.0000190675.08857.3d
   Tammi A, 2001, PEDIATR RES, V50, P688, DOI 10.1203/00006450-200112000-00010
   Tvrzická E, 2002, ANAL CHIM ACTA, V465, P337, DOI 10.1016/S0003-2670(02)00396-3
   Van Guilder GP, 2006, OBESITY, V14, P2127, DOI 10.1038/oby.2006.248
   Vessby B, 2003, CURR OPIN LIPIDOL, V14, P15, DOI 10.1097/00041433-200302000-00004
   Vidgren HM, 1997, EUR J CLIN INVEST, V27, P405, DOI 10.1046/j.1365-2362.1997.1320679.x
   Warensjö E, 2005, DIABETOLOGIA, V48, P1999, DOI 10.1007/s00125-005-1897-x
   Warensjö E, 2006, AM J CLIN NUTR, V84, P442
   Yamada K, 1997, DIABETOLOGIA, V40, P706, DOI 10.1007/s001250050737
   Yazu K, 1996, LIPIDS, V31, P337, DOI 10.1007/BF02529881
   Zanolin ME, 2006, DIABETES CARE, V29, P372, DOI 10.2337/diacare.29.02.06.dc05-1478
NR 62
TC 23
Z9 27
U1 0
U2 8
PU TOHOKU UNIV MEDICAL PRESS
PI SENDAI
PA 2-1, SEIRYO-MACHI, AOBA-KU, SENDAI, MIYAGI 980-8575, JAPAN
SN 0040-8727
EI 1349-3329
J9 TOHOKU J EXP MED
JI Tohoku J. Exp. Med.
PD AUG
PY 2007
VL 212
IS 4
BP 359
EP 371
DI 10.1620/tjem.212.359
PG 13
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 197AX
UT WOS:000248526500003
PM 17660701
OA Bronze
DA 2025-06-11
ER

PT J
AU Shartle, K
   Yang, YC
   Richman, LS
   Belsky, DW
   Aiello, AE
   Harris, KM
AF Shartle, Kaitlin
   Yang, Yang Claire
   Richman, Laura S.
   Belsky, Daniel W.
   Aiello, Allison E.
   Harris, Kathleen Mullan
TI Social Relationships, Wealth, and Cardiometabolic Risk: Evidence from a
   National Longitudinal Study of US Older Adults
SO JOURNAL OF AGING AND HEALTH
LA English
DT Article
DE social relationships; cardiometabolic risk; wealth; trajectories; older
   adults
ID METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; SOCIOECONOMIC-STATUS;
   FUNDAMENTAL CAUSES; HEALTH; MORTALITY; AGE; INTEGRATION; INDICATORS
AB Objectives: To investigate multiple dimensions of social relationships related to biomarkers of cardiometabolic health and how their associations vary by wealth in older adults. Methods: Growth curve models were used to investigate the longitudinal associations between measures of both positive and negative social relationships and cardiometabolic risk (CMR) over a 10-year period from 2006 to 2016 and the moderation of this association by wealth in the Health and Retirement Study (HRS). Results: Older adults with better social relationships had lower CMR on average. The protective effects of positive social relationships, however, waned at older ages, particularly for low-wealth individuals. Discussion: Our results suggest that good social relationships promote healthy aging by buffering against harmful cardiometabolic consequences of psychosocial stress, particularly among relatively wealthy individuals. Efforts to improve old age health would be more effective when focusing simultaneously on fostering social connections and boosting financial resources.
C1 [Shartle, Kaitlin; Yang, Yang Claire; Harris, Kathleen Mullan] Univ N Carolina, Dept Sociol, 155 Pauli Murray Hall, Chapel Hill, NC 27599 USA.
   [Shartle, Kaitlin; Yang, Yang Claire; Aiello, Allison E.; Harris, Kathleen Mullan] Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC 27599 USA.
   [Yang, Yang Claire] Univ N Carolina, Sch Med, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA.
   [Richman, Laura S.] Duke Univ, Sch Med, Durham, NC USA.
   [Belsky, Daniel W.] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA.
   [Aiello, Allison E.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina School of Medicine; Duke University;
   Columbia University; University of North Carolina; University of North
   Carolina Chapel Hill
RP Shartle, K (corresponding author), Univ N Carolina, Dept Sociol, 155 Pauli Murray Hall, Chapel Hill, NC 27599 USA.
EM ksharde@live.unc.edu
RI Belsky, Daniel/HDN-5118-2022
OI Richman, Laura/0000-0002-1381-851X; Shartle,
   Kaitlin/0000-0001-7266-6694; Aiello, Allison/0000-0001-7029-2537
FU NIH [R01 AG057800, R24 HD050924]; University Cancer Research Funds;
   National Institute on Aging [NIA U01AG009740]; National Institute on
   Aging; Social Security Administration; National Institute on Aging
   [U01AG009740, R01AG057800] Funding Source: NIH RePORTER
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This
   research is supported by NIH grants to Yang (R01 AG057800) and to the
   Carolina Population Center for research support (R24 HD050924); and also
   supported by the University Cancer Research Funds to Yang at the
   Lineberger Cancer Center. The HRS (Health and Retirement Study) is
   sponsored by the National Institute on Aging (grant number NIA
   U01AG009740) and is conducted by the University of Michigan. RAND HRS
   Longitudinal File 2016 (V2). Produced by the RAND Center for the Study
   of Aging, with funding from the National Institute on Aging and the
   Social Security Administration. Santa Monica, CA (2020).
CR Berkman LF, 2000, SOC SCI MED, V51, P843, DOI 10.1016/S0277-9536(00)00065-4
   Beutel ME, 2017, BMC PSYCHIATRY, V17, DOI 10.1186/s12888-017-1262-x
   Björntorp P, 1999, ANN NY ACAD SCI, V892, P297, DOI 10.1111/j.1749-6632.1999.tb07803.x
   Brotman DJ, 2007, LANCET, V370, P1089, DOI 10.1016/S0140-6736(07)61305-1
   Brummett BH, 2001, PSYCHOSOM MED, V63, P267, DOI 10.1097/00006842-200103000-00010
   BURBIDGE JB, 1988, J AM STAT ASSOC, V83, P123, DOI 10.2307/2288929
   Cantarero-Prieto D, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0205062
   Choi E, 2018, FRONT PSYCHOL, V9, DOI 10.3389/fpsyg.2018.00003
   Coyle CE, 2017, J AGING HEALTH, V29, P128, DOI 10.1177/0898264315624909
   Crowe CL, 2021, J GERONTOL A-BIOL, V76, P1997, DOI 10.1093/gerona/glab128
   Duncan GJ, 2002, AM J PUBLIC HEALTH, V92, P1151, DOI 10.2105/AJPH.92.7.1151
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Evans IEM, 2019, J ALZHEIMERS DIS, V70, pS119, DOI 10.3233/JAD-180501
   Ford ES, 2006, ANN EPIDEMIOL, V16, P78, DOI 10.1016/j.annepidem.2005.08.005
   Ford ES, 2004, ATHEROSCLEROSIS, V173, P309, DOI 10.1016/j.atherosclerosis.2003.12.022
   Ford ES, 2000, PREV MED, V30, P83, DOI 10.1006/pmed.1999.0606
   Goldman AW, 2016, SOC SCI MED, V166, P137, DOI 10.1016/j.socscimed.2016.07.035
   Hämmig O, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0219663
   Hoffmann R, 2011, J GERONTOL B-PSYCHOL, V66, P374, DOI 10.1093/geronb/gbr014
   Holt-Lunstad J, 2018, ANNU REV PSYCHOL, V69, P437, DOI 10.1146/annurev-psych-122216-011902
   Holt-Lunstad J, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000316
   Holt-Lunstad Julianne., 2017, Public Policy Aging Report, V27, P127, DOI [10.1093/ppar/prx030, DOI 10.1093/PPAR/PRX030]
   HOUSE JS, 1988, SCIENCE, V241, P540, DOI 10.1037/0003-066X.59.8.676
   LINK BG, 1995, J HEALTH SOC BEHAV, V35, P80, DOI 10.2307/2626958
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Pearlin L.I., 1999, HDB SOCIOLOGY MENTAL, DOI DOI 10.1007/0-387-36223-1_19
   PEARLIN LI, 1989, J HEALTH SOC BEHAV, V30, P241, DOI 10.2307/2136956
   Phelan JC, 2010, J HEALTH SOC BEHAV, V51, pS28, DOI 10.1177/0022146510383498
   Raudenbush S. W., 2002, Hierarchical linear models: Applications and data analysis methods
   Robert S, 1996, J AGING HEALTH, V8, P359, DOI 10.1177/089826439600800304
   Rodgers J, 2019, SOC SCI MED, V236, DOI 10.1016/j.socscimed.2019.112360
   Russell DW, 1996, J PERS ASSESS, V66, P20, DOI 10.1207/s15327752jpa6601_2
   Seeman TE, 2002, PSYCHOSOM MED, V64, P395, DOI 10.1097/00006842-200205000-00004
   Seeman TE, 2001, HEALTH PSYCHOL, V20, P243, DOI 10.1037//0278-6133.20.4.243
   Seeman TE, 2014, PSYCHONEUROENDOCRINO, V43, P126, DOI 10.1016/j.psyneuen.2014.02.008
   Shiovitz-Ezra S, 2019, AGING MENT HEALTH, V23, P1358, DOI 10.1080/13607863.2018.1488942
   Snyder-Mackler N, 2020, SCIENCE, V368, P843, DOI 10.1126/science.aax9553
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Sonderlund AL, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0226717
   Sonnega A, 2014, INT J EPIDEMIOL, V43, P576, DOI 10.1093/ije/dyu067
   Szreter S, 2004, INT J EPIDEMIOL, V33, P650, DOI 10.1093/ije/dyh013
   Taylor MG, 2010, J GERONTOL B-PSYCHOL, V65, P733, DOI 10.1093/geronb/gbq018
   Thoits PA, 2010, J HEALTH SOC BEHAV, V51, pS41, DOI 10.1177/0022146510383499
   Umberson D, 2010, ANNU REV SOCIOL, V36, P139, DOI 10.1146/annurev-soc-070308-120011
   Valtorta NK, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2015-010799
   Villalonga-Olives E, 2016, SSM-POPUL HLTH, V2, P613, DOI 10.1016/j.ssmph.2016.08.008
   Weuve J, 2012, EPIDEMIOLOGY, V23, P119, DOI 10.1097/EDE.0b013e318230e861
   Yang YS, 2013, BMC INFECT DIS, V13, DOI 10.1186/1471-2334-13-142
   Yang YC, 2020, J GERONTOL B-PSYCHOL, V75, P613, DOI 10.1093/geronb/gby108
   Yang YC, 2016, P NATL ACAD SCI USA, V113, P578, DOI 10.1073/pnas.1511085112
NR 50
TC 6
Z9 7
U1 0
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0898-2643
EI 1552-6887
J9 J AGING HEALTH
JI J. Aging Health
PD OCT
PY 2022
VL 34
IS 6-8
BP 1048
EP 1061
AR 08982643221087807
DI 10.1177/08982643221087807
EA APR 2022
PG 14
WC Gerontology; Health Policy & Services
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Health Care Sciences & Services
GA 4O7MS
UT WOS:000788410100001
PM 35481380
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Jiao, JT
   Jiang, C
   Huang, J
   Dai, MC
   Wang, C
   Cheng, C
   Shao, JF
AF Jiao, Jian-tong
   Jiang, Chen
   Huang, Jin
   Dai, Min-chao
   Wang, Cheng
   Cheng, Chao
   Shao, Jun-fei
TI RETRACTED: Metabolic syndrome factors and risk of postoperative
   depression in high-grade glioma patients in a 1.5-year prospective study
   (Retracted article. See vol. 34, art no 11, 2014)
SO MEDICAL ONCOLOGY
LA English
DT Article; Retracted Publication
DE High-grade glioma; Postoperative depression; Metabolic syndrome factors;
   Blood glucose
ID CANCER-PATIENTS; NERVOUS-SYSTEM; ENERGY-BALANCE; IMMUNE-SYSTEM;
   BRAIN-TUMORS; YOUNG-ADULTS; INSULIN; HYPERTENSION; COHORT; ASSOCIATION
AB To date, the relationship between metabolic syndrome factors and the risk of glioma-related depression is still unclear, and no study investigates this relationship. Our aim was to investigate the relationship between metabolic syndrome factors and the risk of postoperative depression in high-grade patients. A total of 386 high-grade glioma patients participated in blood sample collection for metabolic syndrome factors analysis and the hospital anxiety and depression scale testing. The association between metabolic syndrome factors and the risk of postoperative depression was assessed using Cox regression proportional hazards models, and Student's t tests were used to evaluate the differences in demographic variables and clinical characteristics in subgroups. The incidence of postoperative depression in our 1.5-year follow-up was 30.5 %. We found the risk of postoperative depression was elevated with increased blood glucose level [hazard ratios (HR) 2.277, 95 % confidence interval (CI) 1.201-4.320, top vs. bottom quartile]. The hazard ratio was increased for z-scores of blood glucose (HR 1.672 per unit standard deviation, 95 % CI 1.311-2.133] and of the combined metabolic syndrome score (HR 1.080, 95 % CI 1.000-1.167). In addition, risk of postoperative depression risk was increased in high-grade glioma patients with high blood glucose levels (>= 6.0 mmol/l) (HR 2.084, 95 % CI 1.235-3.515). However, we did not find significant associations between postoperative depression and other metabolic syndrome factors, including body mass index, systolic blood pressure, diastolic blood pressure, cholesterol, and triglycerides. Depression is prevalent among patients with high-grade glioma after operation. Blood glucose level is positively associated with the risk of postoperative depression, and might be involved in the etiology of postoperative depression, and may predict its development in high-grade glioma patients.
C1 [Jiao, Jian-tong; Jiang, Chen; Huang, Jin; Dai, Min-chao; Wang, Cheng; Cheng, Chao; Shao, Jun-fei] Nanjing Med Univ, Wuxi Peoples Hosp, Dept Neurosurg, Wuxi 214023, Peoples R China.
C3 Nanjing Medical University; Jiangnan University
RP Shao, JF (corresponding author), Nanjing Med Univ, Wuxi Peoples Hosp, Dept Neurosurg, Wuxi 214023, Peoples R China.
EM tongjianjiao@126.com; wxhneurosurgery@126.com
RI Jiang, Chen/W-9403-2018; 程, 超/HCI-6356-2022; Chen, Wei/GZK-7348-2022;
   shao, jianfu/N-2447-2018
OI shao, jianfu/0000-0002-6632-8207
FU National Natural Science Foundation of China (NSFC) [81272791]
FX This work was supported by grants from the National Natural Science
   Foundation of China (NSFC, 81272791).
CR ADER R, 1995, LANCET, V345, P99, DOI 10.1016/S0140-6736(95)90066-7
   Akbaraly TN, 2009, DIABETES CARE, V32, P499, DOI 10.2337/dc08-1358
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Bailey RK, 2005, INT J GYNECOL CANCER, V15, P203, DOI 10.1111/j.1525-1438.2005.15204.x
   Brenner H, 2002, LANCET, V360, P1131, DOI 10.1016/S0140-6736(02)11199-8
   Catt S, 2008, LANCET ONCOL, V9, P884, DOI 10.1016/S1470-2045(08)70230-4
   Edlinger M, 2012, J HYPERTENS, V30, P290, DOI 10.1097/HJH.0b013e32834e9176
   Farooqui AA, 2012, CELL MOL LIFE SCI, V69, P741, DOI 10.1007/s00018-011-0840-1
   Frisardi V, 2010, J ALZHEIMERS DIS, V21, P57, DOI 10.3233/JAD-2010-100015
   Gasecki D, 2013, CURR HYPERTENS REP, V15, P547, DOI 10.1007/s11906-013-0398-4
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Hildrum B, 2009, ACTA PSYCHIAT SCAND, V120, P14, DOI 10.1111/j.1600-0447.2008.01315.x
   Hoyer S, 2002, J NEURAL TRANSM, V109, P341, DOI 10.1007/s007020200028
   Kaaks R, 2001, P NUTR SOC, V60, P91, DOI 10.1079/PNS200070
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Litofsky NS, 2009, J NEURO-ONCOL, V94, P153, DOI 10.1007/s11060-009-9825-4
   Litofsky NS, 2004, NEUROSURGERY, V54, P358, DOI 10.1227/01.NEU.0000103450.94724.A2
   Nation DA, 2010, J INT NEUROPSYCH SOC, V16, P933, DOI 10.1017/S1355617710000548
   Pace A, 2005, NEUROSURGERY, V56, pE628
   Pangilinan PH, 2007, COMMUNITY ONCOL, V4, P533, DOI DOI 10.1016/S1548-5315(11)70030-4
   Peeters PHM, 1998, J HYPERTENS, V16, P941, DOI 10.1097/00004872-199816070-00007
   Perez-Tilve D, 2006, ENDOCRINOLOGY, V147, P1136, DOI 10.1210/en.2005-1586
   Pocai A, 2005, CELL METAB, V1, P53, DOI 10.1016/j.cmet.2004.11.001
   Rabkin SW, 2011, BLOOD PRESSURE, V20, P274, DOI 10.3109/08037051.2011.566246
   Raikkonen K, 1996, METABOLISM, V45, P1533, DOI 10.1016/S0026-0495(96)90184-5
   Räikkönen K, 2001, HYPERTENSION, V38, P798, DOI 10.1161/hyp.38.4.798
   Romanowski CAJ, 2011, NEURORADIOLOGY, V53, pS133, DOI 10.1007/s00234-011-0929-0
   Satin JR, 2009, CANCER-AM CANCER SOC, V115, P5349, DOI 10.1002/cncr.24561
   Seeley RJ, 2005, OBES REV, V6, P259, DOI 10.1111/j.1467-789X.2005.00193.x
   Stocks T, 2009, PLOS MED, V6, DOI 10.1371/journal.pmed.1000201
   Strader AD, 2005, GASTROENTEROLOGY, V128, P175, DOI 10.1053/j.gastro.2004.10.043
   Takahashi Y, 2011, INTERNAL MED, V50, P1671, DOI 10.2169/internalmedicine.50.4871
   Takeuchi T, 2009, DIABETES METAB, V35, P32, DOI 10.1016/j.diabet.2008.06.006
   Takeuchi T, 2009, DIABETES-METAB RES, V25, P762, DOI 10.1002/dmrr.1041
   Tulinius H, 1997, CANCER EPIDEM BIOMAR, V6, P863
   Wakefield JC, 2007, ARCH GEN PSYCHIAT, V64, P433, DOI 10.1001/archpsyc.64.4.433
   Weber-Hamann B, 2002, PSYCHOSOM MED, V64, P274, DOI 10.1097/00006842-200203000-00010
   Weitzner MA, 1999, CANCER INVEST, V17, P285, DOI 10.3109/07357909909040599
   Yirmiya R, 2000, WESTERN J MED, V173, P333, DOI 10.1136/ewjm.173.5.333
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 40
TC 8
Z9 9
U1 0
U2 12
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1357-0560
EI 1559-131X
J9 MED ONCOL
JI Med. Oncol.
PD OCT
PY 2014
VL 31
IS 10
AR 234
DI 10.1007/s12032-014-0234-y
PG 8
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA AP4WG
UT WOS:000342079600049
PM 25223530
DA 2025-06-11
ER

PT J
AU Kahl, KG
   Greggersen, W
   Schweiger, U
   Cordes, J
   Balijepalli, C
   Lösch, C
   Moebus, S
AF Kahl, Kai G.
   Greggersen, Wiebke
   Schweiger, Ulrich
   Cordes, Joachim
   Balijepalli, Chakrapani
   Loesch, Christian
   Moebus, Susanne
TI Prevalence of the metabolic syndrome in unipolar major depression
SO EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
LA English
DT Article
DE Major depression; Metabolic syndrome; Physical health; Anxiety disorder
ID INSULIN-RESISTANCE; BIPOLAR-DISORDER; CARDIOVASCULAR-DISEASE;
   YOUNG-ADULTS; FOLLOW-UP; RISK; WOMEN; ASSOCIATION; SYMPTOMS; ANXIETY
AB Previous studies on the association between affective disorders and the metabolic syndrome yielded inconclusive results. Therefore, we examined the prevalence of the metabolic syndrome in 230 men and women with unipolar major depressive disorder during inpatient treatment and compared it to 1,673 subjects from primary care from a similar region in northern Germany. We used the AHA/NHBLI criteria to determine the rate of metabolic syndrome (MetS) and each single criterion of MetS in both groups. The age-standardized prevalence of MetS was 2.4x as high in patients with major depressive disorder (MDD) compared with data from comparison subjects (41.0% vs. 17.0%). With respect to the single criteria, elevations were found in MDD patients for fasting glucose and triglycerides in both genders, and waist circumference in women. Men in the patient and the comparison groups were found to have higher rates of increased fasting glucose and triglycerides than women in the respective groups. Factors associated with the MetS in MDD patients comprise body mass index and the severity of depression. Our results demonstrate an increased prevalence of the MetS in men and women with MDD. Interventions for the frequently untreated metabolic abnormalities and careful screening for physical health conditions among people with MDD are warranted.
C1 [Kahl, Kai G.] Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, D-30625 Hannover, Germany.
   [Greggersen, Wiebke; Schweiger, Ulrich] Luebeck Med Sch, Dept Psychiat & Psychotherapy, Lubeck, Germany.
   [Cordes, Joachim] Univ Dusseldorf, Dept Psychiat & Psychotherapy, D-40225 Dusseldorf, Germany.
   [Balijepalli, Chakrapani; Loesch, Christian; Moebus, Susanne] Univ Duisburg Essen, Univ Hosp Essen, Inst Med Informat Biometry & Epidemiol, Essen, Germany.
C3 Hannover Medical School; Heinrich Heine University Dusseldorf;
   University of Duisburg Essen
RP Kahl, KG (corresponding author), Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM Kahl.Kai@mh-hannover.de
OI Moebus, Susanne/0000-0002-0072-5410
CR Adriaanse MC, 2006, DIABETOLOGIA, V49, P2874, DOI 10.1007/s00125-006-0500-4
   Agyemang C, 2010, INT J CARDIOL, V141, P266, DOI 10.1016/j.ijcard.2008.12.023
   Alonso J, 2004, ACTA PSYCHIAT SCAND, V109, P21
   Boissonnet C., 2011, Eur J Cardiovasc Prev Rehabil, V18, P550, DOI DOI 10.1177/1741826710389418
   Brown ES, 2004, BIOL PSYCHIAT, V55, P1, DOI 10.1016/S0006-3223(03)00473-6
   Cohn T, 2004, CAN J PSYCHIAT, V49, P753, DOI 10.1177/070674370404901106
   Cuppett M, 2002, J ATHL TRAINING, V37, P281
   De Hert M, 2009, EUR PSYCHIAT, V24, P412, DOI 10.1016/j.eurpsy.2009.01.005
   DiBello JR, 2009, J NUTR, V139, P1933, DOI 10.3945/jn.109.107888
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Greggersen W, 2011, EUR ARCH PSY CLIN N, V261, P551, DOI 10.1007/s00406-011-0194-6
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Grundy SM, 2002, AM J MED, V113, P25, DOI 10.1016/S0002-9343(01)00988-3
   Gustafsson PE, 2011, ANN EPIDEMIOL, V21, P103, DOI 10.1016/j.annepidem.2010.08.012
   Hamada A, 2010, J BIOMED SCI, V17, DOI 10.1186/1423-0127-17-S1-S34
   Hanley AJG, 2009, DIABETOLOGIA, V52, P2079, DOI 10.1007/s00125-009-1464-y
   Hauner H, 2008, EXP CLIN ENDOCR DIAB, V116, P18, DOI 10.1055/s-2007-985359
   Heiskanen T, 2003, J CLIN PSYCHIAT, V64, P575, DOI 10.4088/JCP.v64n0513
   Heiskanen TH, 2006, J CLIN PSYCHIAT, V67, P1422, DOI 10.4088/JCP.v67n0913
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Hildrum B, 2009, ACTA PSYCHIAT SCAND, V120, P14, DOI 10.1111/j.1600-0447.2008.01315.x
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Kahl KG, 2005, PSYCHOSOM MED, V67, P407, DOI 10.1097/01.psy.0000160458.95955.f4
   Kapczinski F, 2008, NEUROSCI BIOBEHAV R, V32, P675, DOI 10.1016/j.neubiorev.2007.10.005
   Karlamangla AS, 2010, ANN EPIDEMIOL, V20, P617, DOI 10.1016/j.annepidem.2010.05.003
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Laaksonen DE, 2002, AM J EPIDEMIOL, V156, P1070, DOI 10.1093/aje/kwf145
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   LAPIDUS L, 1984, BMJ-BRIT MED J, V289, P1257, DOI 10.1136/bmj.289.6454.1257
   Lopez-Duran NL, 2009, PSYCHONEUROENDOCRINO, V34, P1272, DOI 10.1016/j.psyneuen.2009.03.016
   McIntyre RS, 2006, CAN J PSYCHIAT, V51, P274, DOI 10.1177/070674370605100502
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Miettola J, 2008, SCAND J PRIM HEALTH, V26, P203, DOI 10.1080/02813430802117624
   Moebus Susanne, 2006, Ger Med Sci, V4, pDoc07
   Pjrek E, 2007, EUR ARCH PSY CLIN N, V257, P197, DOI 10.1007/s00406-006-0706-y
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Richter N, 2010, EUR ARCH PSY CLIN N, V260, P41, DOI 10.1007/s00406-009-0013-5
   Saari KM, 2005, J CLIN PSYCHIAT, V66, P559, DOI 10.4088/JCP.v66n0503
   Sarandol A, 2006, PROG NEURO-PSYCHOPH, V30, P1103, DOI 10.1016/j.pnpbp.2006.04.012
   Shin A, 2009, J AM DIET ASSOC, V109, P633, DOI 10.1016/j.jada.2008.12.015
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Timonen M, 2005, BMJ-BRIT MED J, V330, P17, DOI 10.1136/bmj.38313.513310.F71
   Toker S, 2008, DEPRESS ANXIETY, V25, P661, DOI 10.1002/da.20379
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
   Vanhala M, 2009, ACTA PSYCHIAT SCAND, V119, P137, DOI 10.1111/j.1600-0447.2008.01283.x
   Viinamäki H, 2009, ACTA PSYCHIAT SCAND, V120, P23, DOI 10.1111/j.1600-0447.2008.01333.x
   Vogelzangs N, 2007, PSYCHONEUROENDOCRINO, V32, P151, DOI 10.1016/j.psyneuen.2006.11.009
   Young E, 2010, MOL PSYCHIATR, V15, P23, DOI 10.1038/mp.2009.94
NR 49
TC 60
Z9 62
U1 0
U2 13
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0940-1334
EI 1433-8491
J9 EUR ARCH PSY CLIN N
JI Eur. Arch. Psych. Clin. Neurosci.
PD JUN
PY 2012
VL 262
IS 4
BP 313
EP 320
DI 10.1007/s00406-011-0277-4
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 952TM
UT WOS:000304815300005
PM 22183567
DA 2025-06-11
ER

PT J
AU Johnson, CC
   Sheffield, KM
   Brown, RE
AF Johnson, Candace C.
   Sheffield, Karen M.
   Brown, Roy E.
TI Mind-Body Therapies for African-American Women at Risk for
   Cardiometabolic Disease: A Systematic Review
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Review
ID METABOLIC SYNDROME; PHYSICAL-ACTIVITY; US ADULTS; HEART-DISEASE;
   PREVALENCE; STRESS; MANAGEMENT; HEALTH; INTERVENTION; OBESITY
AB Background. A major determinant in cardiometabolic health is metabolic syndrome (MetS), a cluster of symptoms that portend the development of cardiovascular disease (CVD). As mind-body therapies are thought to help in lowering physiological and environmental CVD risk factors including blood pressure and psychological stress, they may also be beneficial for the primary prevention of CVD. Objectives. To synthesize and summarize existing knowledge on the effectiveness of mind-body therapies on MetS outcomes in African-American (AA) women, a US subpopulation at high risk for CVD. Search Methods. A systematic search of eight databases was conducted in order to identify published papers addressing the topic. We included trials involving AA adult women, ages 18-64, and we included RCTs that involved multifactorial interventions. Outcomes of interest were MetS, chronic disease, and CVD risk factors (blood pressure, blood lipids, blood glucose, BMI, waist circumference, and mental health domains). Two authors independently selected trials for inclusion, extracted data, and assessed risks of bias. Main Results. We identified five trials for inclusion in this review. One study reported outcomes associated with the full MetS symptom cluster. The included trials were small, short term, and at high risk of bias. All interventions lasted at least 6 weeks.
C1 [Johnson, Candace C.] Virginia Commonwealth Univ, Sch Nursing, Dept Family & Community Hlth Nursing, 1100 E Leigh St,POB 980567, Richmond, VA 23298 USA.
   [Sheffield, Karen M.] Univ N Carolina, Chapel Hill Sch Nursing, 307 E Carrington Hall,Campus Box 7460, Chapel Hill, NC 27599 USA.
   [Brown, Roy E.] Virginia Commonwealth Univ, Sch Nursing, Tompkins McCaw Lib Hlth Sci, 509 N 12th St,POB 980582, Richmond, VA 23298 USA.
C3 Virginia Commonwealth University; University of North Carolina;
   University of North Carolina Chapel Hill; Virginia Commonwealth
   University
RP Johnson, CC (corresponding author), Virginia Commonwealth Univ, Sch Nursing, Dept Family & Community Hlth Nursing, 1100 E Leigh St,POB 980567, Richmond, VA 23298 USA.
EM johnsoncm7@vcu.edu
RI Brown, Roy/J-5428-2019
FU National Institute of Nursing Research [T32NR007091]; Virginia
   Commonwealth University School of Nursing
FX Ms. Sheffield received financial support from the National Institute of
   Nursing Research under Award no. T32NR007091 (MPIs: S. Santacroce, J.
   Leeman). Dr. Johnson received financial support from an internal grant
   at Virginia Commonwealth University School of Nursing.
CR Abrams JA, 2014, PSYCHOL WOMEN QUART, V38, P503, DOI 10.1177/0361684314541418
   Anderson JG, 2011, J NUTR METAB, V2011, DOI 10.1155/2011/276419
   Anic GM, 2010, SLEEP MED, V11, P447, DOI 10.1016/j.sleep.2009.11.013
   [Anonymous], 2014, NAT DIAB STAT REP ES
   [Anonymous], 2010, BMJ-BRIT MED J, DOI DOI 10.1136/BMJ.C3515
   Aromataris E, 2014, AM J NURS, V114, P53, DOI 10.1097/01.NAJ.0000444496.24228.2c
   Bernstein AM, 2014, PUBLIC HEALTH, V128, P674, DOI 10.1016/j.puhe.2014.04.005
   Black AR, 2011, AM J PUBLIC HEALTH, V101, P144, DOI 10.2105/AJPH.2009.167817
   Bradshaw PT, 2013, OBESITY, V21, P203, DOI 10.1002/oby.20248
   Burnett-Zeigler IE, 2016, COMPLEMENT THER CLIN, V25, P59, DOI 10.1016/j.ctcp.2016.08.007
   Clarke Tainya C, 2015, Natl Health Stat Report, P1
   Cox TL, 2013, HEALTH EDUC BEHAV, V40, P78, DOI 10.1177/1090198112439411
   Eyler AE, 2002, J WOMEN HEALTH GEN-B, V11, P239, DOI 10.1089/152460902753668448
   Field Tiffany, 2010, Complement Ther Clin Pract, V16, P235, DOI 10.1016/j.ctcp.2010.05.014
   Ford ES, 2010, J DIABETES, V2, P180, DOI 10.1111/j.1753-0407.2010.00078.x
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Grandner MA, 2010, SLEEP MED REV, V14, P191, DOI 10.1016/j.smrv.2009.07.006
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Hartley L, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010359.pub2
   Holmes ME, 2010, OBES REV, V11, P492, DOI 10.1111/j.1467-789X.2009.00680.x
   Innes KE, 2007, EVID-BASED COMPL ALT, V4, P469, DOI 10.1093/ecam/nel103
   Jefferson Lenetra L, 2010, J Natl Black Nurses Assoc, V21, P17
   Khan RJ, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2015-008675
   Krantz DS, 2002, ANNU REV PSYCHOL, V53, P341, DOI 10.1146/annurev.psych.53.100901.135208
   Kwagyan J, 2015, ETHNIC DIS, V25, P208
   Lloyd-Jones D, 2010, CIRCULATION, V121, P948, DOI 10.1161/CIRCULATIONAHA.109.192666
   Mama SK, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0154035
   McIntyre Roger S, 2007, Ann Clin Psychiatry, V19, P257, DOI 10.1080/10401230701653377
   Mozaffarian D, 2016, CIRCULATION, V133, pE38, DOI 10.1161/CIR.0000000000000350
   Mozumdar A, 2011, DIABETES CARE, V34, P216, DOI 10.2337/dc10-0879
   Ogden CL, 2012, JAMA-J AM MED ASSOC, V307, P483, DOI [10.1001/jama.2012.39, 10.1001/jama.2012.40]
   Olano HA, 2015, J ALTERN COMPLEM MED, V21, P100, DOI 10.1089/acm.2014.0269
   Raub JA, 2002, J ALTERN COMPLEM MED, V8, P797, DOI 10.1089/10755530260511810
   Samson SL, 2014, ENDOCRIN METAB CLIN, V43, P1, DOI 10.1016/j.ecl.2013.09.009
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Spiegel K, 2005, J APPL PHYSIOL, V99, P2008, DOI 10.1152/japplphysiol.00660.2005
   Sterne JAC, 2000, J CLIN EPIDEMIOL, V53, P1119, DOI 10.1016/S0895-4356(00)00242-0
   Sterne JAC, 2001, BMJ-BRIT MED J, V323, P101, DOI 10.1136/bmj.323.7304.101
   Taylor AG, 2010, EXPLORE-NY, V6, P29, DOI 10.1016/j.explore.2009.10.004
   Vanhala M, 2009, ACTA PSYCHIAT SCAND, V119, P137, DOI 10.1111/j.1600-0447.2008.01283.x
   Webb FJ, 2016, J COMMUN HEALTH, V41, P368, DOI 10.1007/s10900-015-0106-1
   Webb M S, 2000, J Natl Black Nurses Assoc, V11, P1
   Woods-Giscombé CL, 2014, J HOLIST NURS, V32, P147, DOI 10.1177/0898010113519010
   Woods-Giscombé CL, 2010, QUAL HEALTH RES, V20, P668, DOI 10.1177/1049732310361892
   Yogendra J, 2004, J Assoc Physicians India, V52, P283
   Youug DR, 2006, FAM COMMUNITY HEALTH, V29, P103, DOI 10.1097/00003727-200604000-00006
NR 46
TC 6
Z9 6
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2018
VL 2018
AR 5123217
DI 10.1155/2018/5123217
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA FY9JB
UT WOS:000427180600001
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Hulteen, RM
   Marlatt, KL
   Allerton, TD
   Lovre, D
AF Hulteen, Ryan M. M.
   Marlatt, Kara L. L.
   Allerton, Timothy D. D.
   Lovre, Dragana
TI Detrimental Changes in Health during Menopause: The Role of Physical
   Activity
SO INTERNATIONAL JOURNAL OF SPORTS MEDICINE
LA English
DT Review
DE menopause; physical activity; exercise; metabolism; adiposity; insulin
   resistance
ID BONE-MINERAL DENSITY; HABITUAL AEROBIC EXERCISE; NITRIC-OXIDE
   PRODUCTION; POSTMENOPAUSAL WOMEN; WEIGHT-LOSS; MIDLIFE WOMEN;
   ENDOTHELIAL FUNCTION; INSULIN SENSITIVITY; ENERGY-EXPENDITURE;
   BODY-COMPOSITION
AB Midlife women experience changes in cardiometabolic, physical, and psychosocial health during menopause that negatively impacts their overall quality of life. Factors that contribute to these increases in cardiometabolic risk include weight gain as well as increases in fat mass (particularly abdominal adiposity), insulin resistance, and vascular dysfunction. Other deleterious changes in physical health (e. g. reduced sleep health, bone density, and balance) as well as changes in psychosocial health (e. g. mood, anxiety, and depression) often coincide and are linked to these increases in cardiometabolic risk. Physical activity and exercise are important lifestyle components that have been demonstrated to improve cardiometabolic, physical, and psychosocial health, yet physical activity and exercise is known to decline during perimenopause and into the postmenopausal years. In this narrative review, we summarize these changes in overall health during menopause as well as how declining physical activity contributes to these changes. Additionally, we discuss how incorporating physical activity and exercise during menopause can potentially ameliorate health declines. We conclude that there exists a significant, positive impact of physical activity on cardiometabolic, physical, and psychological health among midlife women, particularly if undertaken during the perimenopausal and postmenopausal years.
C1 [Hulteen, Ryan M. M.] Louisiana State Univ, Kinesiol, 2229 Pleasant Hall, Baton Rouge, LA 70809 USA.
   [Marlatt, Kara L. L.] Pennington Biomed Res Ctr, Clin Sci, Baton Rouge, LA USA.
   [Allerton, Timothy D. D.] Pennington Biomed Res Ctr, Basic Sci, Baton Rouge, LA USA.
   [Lovre, Dragana] Tulane Univ Hlth Sci Ctr, Sch Med, New Orleans, LA USA.
   [Lovre, Dragana] Southeast Louisiana Vet Hlth Care Syst, Medicine, New Orleans, LA USA.
C3 Louisiana State University System; Louisiana State University; Louisiana
   State University System; Louisiana State University; Pennington
   Biomedical Research Center; Louisiana State University System; Louisiana
   State University; Pennington Biomedical Research Center; Tulane
   University; Tulane University Hospital
RP Hulteen, RM (corresponding author), Louisiana State Univ, Kinesiol, 2229 Pleasant Hall, Baton Rouge, LA 70809 USA.
RI Hulteen, Ryan/AFK-7703-2022; Lovre, Dragana/AAA-1832-2020
FU National Institute of General Medical Sciences; Biomedical Laboratory
   Research and Development, VA Office of Research and Development [P30
   GM118430]; National Institute of Diabetes and Digestive and Kidney
   Diseases [IK2 CX002225]
FX National Institute of General Medical Sciences -
   http://dx.doi.org/10.13039/100000057; P30 GM118430 Biomedical Laboratory
   Research and Development, VA Office of Research and Development -
   http://dx.doi.org/10.13039/100007496; IK2 CX002225 National Institute of
   Diabetes and Digestive and Kidney Diseases -
   http://dx.doi.org/10.13039/100000062; K01 DK128227
CR [Anonymous], 2015, Nat Rev Dis Primers, V1, P15054, DOI 10.1038/nrdp.2015.54
   Best PJM, 1998, ANN INTERN MED, V128, P285, DOI 10.7326/0003-4819-128-4-199802150-00006
   Black MA, 2009, AM J PHYSIOL-HEART C, V297, pH1109, DOI 10.1152/ajpheart.00226.2009
   Blumenthal JA, 1999, ARCH INTERN MED, V159, P2349, DOI 10.1001/archinte.159.19.2349
   BOGARDUS C, 1986, NEW ENGL J MED, V315, P96, DOI 10.1056/NEJM198607103150205
   BOGARDUS C, 1985, AM J PHYSIOL, V248, pE286, DOI 10.1152/ajpendo.1985.248.3.E286
   Bromberger JT, 2011, PSYCHOL MED, V41, P1879, DOI 10.1017/S003329171100016X
   Bromberger JT, 2019, PSYCHOL MED, V49, P250, DOI 10.1017/S0033291718000703
   Bromberger JT, 2010, ARCH GEN PSYCHIAT, V67, P598, DOI 10.1001/archgenpsychiatry.2010.55
   Brown MD, 2000, DIABETES CARE, V23, P1731, DOI 10.2337/diacare.23.12.1731
   Bruns CM, 2004, ILAR J, V45, P160, DOI 10.1093/ilar.45.2.160
   Cheng CC, 2018, MENOPAUSE, V25, P772, DOI 10.1097/GME.0000000000001085
   Cheng MH, 2009, MENOPAUSE, V16, P892, DOI 10.1097/gme.0b013e3181a0e091
   Choquette S, 2011, BRIT J NUTR, V105, P1199, DOI 10.1017/S0007114510004897
   Church TS, 2010, JAMA-J AM MED ASSOC, V304, P2253, DOI 10.1001/jama.2010.1710
   Cohen LS, 2006, ARCH GEN PSYCHIAT, V63, P385, DOI 10.1001/archpsyc.63.4.385
   da Câmara SMA, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0119480
   Darblade B, 2002, CIRC RES, V90, P413, DOI 10.1161/hh0402.105096
   Davidson LE, 2009, ARCH INTERN MED, V169, P122, DOI 10.1001/archinternmed.2008.558
   Dugan SA, 2015, MED SCI SPORT EXER, V47, P335, DOI 10.1249/MSS.0000000000000407
   Duval K, 2013, EUR J CLIN NUTR, V67, P407, DOI 10.1038/ejcn.2013.33
   El Khoudary SR, 2020, CIRCULATION, V142, pe506, DOI 10.1161/CIR.0000000000000912
   El Khoudary SR, 2019, MENOPAUSE, V26, P1213, DOI 10.1097/GME.0000000000001424
   Frank LL, 2005, OBES RES, V13, P615, DOI 10.1038/oby.2005.66
   Freeman EW, 2004, ARCH GEN PSYCHIAT, V61, P62, DOI 10.1001/archpsyc.61.1.62
   Fu S, 2009, CLIMACTERIC, V12, P165, DOI 10.1080/13697130802506614
   Fukuma N, 2020, JACC-BASIC TRANSL SC, V5, P282, DOI 10.1016/j.jacbts.2019.12.009
   Gabriel KP, 2017, PREV MED, V105, P287, DOI 10.1016/j.ypmed.2017.10.005
   Godsland IF, 2005, DIABETOLOGIA, V48, P2213, DOI 10.1007/s00125-005-1930-0
   Gold EB, 2001, AM J EPIDEMIOL, V153, P865, DOI 10.1093/aje/153.9.865
   Gold EB, 2013, AM J EPIDEMIOL, V178, P70, DOI 10.1093/aje/kws421
   Gozansky WS, 2005, J CLIN ENDOCR METAB, V90, P52, DOI 10.1210/jc.2004-0275
   Greendale GA, 2019, JCI INSIGHT, V4, DOI 10.1172/jci.insight.124865
   Greendale GA, 2012, J BONE MINER RES, V27, P111, DOI 10.1002/jbmr.534
   Hansen PA, 1998, J APPL PHYSIOL, V85, P1218, DOI 10.1152/jappl.1998.85.4.1218
   Harlow SD, 2018, OBSTET GYN CLIN N AM, V45, P599, DOI 10.1016/j.ogc.2018.07.003
   Harlow SD, 2012, CLIMACTERIC, V15, P105, DOI [10.1210/jc.2011-3362, 10.3109/13697137.2011.650656, 10.1016/j.fertnstert.2012.01.128, 10.1097/gme.0b013e31824d8f40]
   Hawley JA, 2008, ACTA PHYSIOL, V192, P127, DOI 10.1111/j.1748-1716.2007.01783.x
   Heymsfield SB, 2014, OBES REV, V15, P310, DOI 10.1111/obr.12143
   Holden DP, 2003, CIRCULATION, V108, P1575, DOI 10.1161/01.CIR.0000091083.61609.DF
   Houmard JA, 2004, J APPL PHYSIOL, V96, P101, DOI 10.1152/japplphysiol.00707.2003
   Hulteen RM, 2017, PREV MED, V95, P14, DOI 10.1016/j.ypmed.2016.11.027
   Hyvärinen M, 2022, INT J OBESITY, V46, P544, DOI 10.1038/s41366-021-01022-x
   Irwin ML, 2003, JAMA-J AM MED ASSOC, V289, P323, DOI 10.1001/jama.289.3.323
   Juppi HK, 2022, AGING CELL, V21, DOI 10.1111/acel.13621
   Karlamangla AS, 2018, OBSTET GYN CLIN N AM, V45, P695, DOI 10.1016/j.ogc.2018.07.012
   Kelley GA, 2002, J GERONTOL A-BIOL, V57, pM599, DOI 10.1093/gerona/57.9.M599
   Kim JW, 2012, METAB SYNDR RELAT D, V10, P452, DOI 10.1089/met.2012.0036
   Kistler-Fischbacher M, 2021, BONE, V143, DOI 10.1016/j.bone.2020.115697
   Kline CE, 2014, AM J LIFESTYLE MED, V8, P375, DOI 10.1177/1559827614544437
   Kline CE, 2013, SLEEP, V36, P1279, DOI 10.5665/sleep.2946
   Kline CE, 2012, BMJ OPEN, V2, DOI 10.1136/bmjopen-2012-001044
   Kravitz HM, 2018, OBSTET GYN CLIN N AM, V45, P679, DOI 10.1016/j.ogc.2018.07.008
   Kravitz HM, 2011, OBSTET GYN CLIN N AM, V38, P567, DOI 10.1016/j.ogc.2011.06.002
   Lakatta EG, 2003, CIRCULATION, V107, P139, DOI 10.1161/01.CIR.0000048892.83521.58
   Lam CSP, 2012, CIRC-HEART FAIL, V5, P571, DOI 10.1161/CIRCHEARTFAILURE.112.970061
   Lam CSP, 2011, EUR J HEART FAIL, V13, P18, DOI 10.1093/eurjhf/hfq121
   Lambiase MJ, 2013, MENOPAUSE, V20, P946, DOI [10.1097/gme.0b013e3182844110, 10.1097/GME.0b013e3182844110]
   Lewis TV, 1999, ARTERIOSCL THROM VAS, V19, P2782, DOI 10.1161/01.ATV.19.11.2782
   Lorentzon M, 2022, CLIMACTERIC, V25, P4, DOI 10.1080/13697137.2021.1951206
   Lovejoy JC, 2008, INT J OBESITY, V32, P949, DOI 10.1038/ijo.2008.25
   Mandrup CM, 2017, AM J OBSTET GYNECOL, V216, DOI 10.1016/j.ajog.2016.12.017
   Mansikkamäki K, 2012, MATURITAS, V72, P339, DOI 10.1016/j.maturitas.2012.05.003
   Margolis KL, 2004, DIABETOLOGIA, V47, P1175, DOI 10.1007/s00125-004-1448-x
   Marlatt KL, 2022, OBESITY, V30, P14, DOI 10.1002/oby.23289
   Marlatt KL, 2020, AM J OBSTET GYNECOL, V222, DOI 10.1016/j.ajog.2019.09.051
   Martyn-St James M, 2006, OSTEOPOROSIS INT, V17, P1225, DOI 10.1007/s00198-006-0083-4
   Martyn-St James M, 2008, BONE, V43, P521, DOI 10.1016/j.bone.2008.05.012
   Mason C, 2011, AM J PREV MED, V41, P366, DOI 10.1016/j.amepre.2011.06.042
   Mauvais-Jarvis F, 2017, ENDOCR REV, V38, P173, DOI 10.1210/er.2016-1146
   McLafferty CL, 2004, PERCEPT MOTOR SKILL, V98, P947
   Messier V, 2011, MATURITAS, V68, P331, DOI 10.1016/j.maturitas.2011.01.014
   Mishra GD, 2007, DIABETES CARE, V30, P1418, DOI 10.2337/dc06-2187
   Moreau KL, 2013, J CLIN ENDOCR METAB, V98, P4507, DOI 10.1210/jc.2013-2183
   Moreau KL, 2012, J CLIN ENDOCR METAB, V97, P4692, DOI 10.1210/jc.2012-2244
   Nazrun AS, 2014, THER CLIN RISK MANAG, V10, P937, DOI 10.2147/TCRM.S72456
   Nyberg M, 2016, HYPERTENSION, V68, P1011, DOI 10.1161/HYPERTENSIONAHA.116.07866
   PALMER RMJ, 1987, NATURE, V327, P524, DOI 10.1038/327524a0
   Patten RD, 2008, J CARD FAIL, V14, P245, DOI 10.1016/j.cardfail.2007.10.024
   Pettee Gabriel Kelley, 2015, Womens Midlife Health, V1, P1, DOI 10.1186/s40695-015-0004-9
   Pierce GL, 2011, CLIN SCI, V120, P13, DOI 10.1042/CS20100174
   Polotsky HN, 2010, SEMIN REPROD MED, V28, P426, DOI 10.1055/s-0030-1262902
   RAVUSSIN E, 1986, J CLIN INVEST, V78, P1568, DOI 10.1172/JCI112749
   Recker R, 2000, J BONE MINER RES, V15, P1965, DOI 10.1359/jbmr.2000.15.10.1965
   Reed SD, 2014, AM J OBSTET GYNECOL, V210, DOI 10.1016/j.ajog.2013.11.016
   RICHTER EA, 1982, J CLIN INVEST, V69, P785, DOI 10.1172/JCI110517
   Ross R, 2004, OBES RES, V12, P789, DOI 10.1038/oby.2004.95
   Ruiz-Rios M, 2022, MENOPAUSE, V29, P1222, DOI 10.1097/GME.0000000000002037
   Salzano A, 2021, HEART FAIL CLIN, V17, P397, DOI 10.1016/j.hfc.2021.03.004
   Santos-Parker JR, 2017, J APPL PHYSIOL, V122, P11, DOI 10.1152/japplphysiol.00732.2016
   Schmid SM, 2015, LANCET DIABETES ENDO, V3, P52, DOI 10.1016/S2213-8587(14)70012-9
   Schultz AB, 1997, MUSCLE NERVE, pS60
   Serra MC, 2017, ANN NUTR METAB, V70, P312, DOI 10.1159/000475766
   Shea KL, 2015, MENOPAUSE, V22, P1045, DOI 10.1097/GME.0000000000000430
   Simkin-Silverman LR, 2003, ANN BEHAV MED, V26, P212, DOI 10.1207/S15324796ABM2603_06
   Soriguer F, 2009, MENOPAUSE, V16, P817, DOI [10.1097/GME.0b013e31819d4113, 10.1097/gme.0b013e31819d4113]
   Sternfeld B, 2005, MED SCI SPORT EXER, V37, P1195, DOI 10.1249/01.mss.0000170083.41186.b1
   Sternfeld B, 2014, MENOPAUSE, V21, P330, DOI 10.1097/GME.0b013e31829e4089
   Swift DL, 2014, J WOMENS HEALTH, V23, P260, DOI 10.1089/jwh.2013.4420
   Tan EQ, 1999, CARDIOVASC RES, V43, P788, DOI 10.1016/S0008-6363(99)00159-5
   Thurston RC, 2018, CLIMACTERIC, V21, P96, DOI 10.1080/13697137.2018.1430131
   Ungvari Z, 2018, CIRC RES, V123, P849, DOI 10.1161/CIRCRESAHA.118.311378
   US Department of Health and Human Services, 2018, Physical activity guidelines for Americans
   van Eickels M, 2001, CIRCULATION, V104, P1419, DOI 10.1161/hc3601.095577
   van Gemert WA, 2019, BMC PUBLIC HEALTH, V19, DOI 10.1186/s12889-019-6510-1
   Villareal DT, 2006, ARCH INTERN MED, V166, P2502, DOI 10.1001/archinte.166.22.2502
   Wallace BA, 2000, CALCIFIED TISSUE INT, V67, P10, DOI 10.1007/s00223001089
   WALLACE RB, 1979, AM J OBSTET GYNECOL, V135, P1021, DOI 10.1016/0002-9378(79)90729-4
   Weicker H, 2001, AMINO ACIDS, V20, P35, DOI 10.1007/s007260170064
   Wilbur JoEllen, 2005, Res Theory Nurs Pract, V19, P163, DOI 10.1891/088971805780957404
   Woods NF, 2008, MENOPAUSE, V15, P223, DOI 10.1097/gme.0b013e3181450fc2
   Yan H, 2019, DIABETES, V68, P291, DOI 10.2337/db18-0638
NR 112
TC 15
Z9 15
U1 11
U2 40
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0172-4622
EI 1439-3964
J9 INT J SPORTS MED
JI Int. J. Sports Med.
PD JUN
PY 2023
VL 44
IS 06
BP 389
EP 396
DI 10.1055/a-2003-9406
EA FEB 2023
PG 8
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA H7DO0
UT WOS:000936123600003
PM 36807278
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Vogelzangs, N
   Suthers, K
   Ferrucci, L
   Simonsick, EM
   Ble, A
   Schrager, M
   Bandinelli, S
   Lauretani, F
   Giannelli, SV
   Penninx, BW
AF Vogelzangs, Nicole
   Suthers, Kristen
   Ferrucci, Luigi
   Simonsick, Eleanor M.
   Ble, Alessandro
   Schrager, Matthew
   Bandinelli, Stefania
   Lauretani, Fulvio
   Giannelli, Sandra V.
   Penninx, Brenda W.
TI Hypercortisolemic depression is associated with the metabolic syndrome
   in late-life
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE depression; cortisol; HPA-axis; metabolic syndrome; older persons
ID 3RD NATIONAL-HEALTH; INSULIN-RESISTANCE; MAJOR DEPRESSION; PSYCHOLOGICAL
   RISK; STRESS; SYMPTOMS; CORTISOL; HEART; MOOD; MORTALITY
AB Introduction: Depression has been hypothesized to be associated with metabolic abnormalities which increase the risk of cardiovascular disease (CVD) and diabetes. Such a link could be due to increased HPA-axis activity. This study investigates the cross-sectional relationship between depression, urinary cortisol and metabolic syndrome in an older population.
   Methods: Data are from 867 participants of the InChianti Study, aged >=,65 years. Depressive symptoms were assessed using the CES-D scale; cortisol levels were determined in 24-h urine samples. Metabolic syndrome was defined as three or more of the following: abdominal obesity, high triglycerides, tow HDL cholesterol, high blood pressure, and high fasting glucose.
   Results: Clinically relevant depressed mood (CES-D >= 20) was present in 20.6% of the sample, and 24.5% had the metabolic syndrome. After adjustment for sociodemographics and health indicators, depression score (per SD increase: OR = 1.20, 95% Cl = 1.02-1.41) and urinary cortisot level (per SD increase: OR = 1.23, 95% Cl = 1.01-1.51) were significantly associated with presence of metabolic syndrome. There was, however, a significant interaction (p = 0.003) between depressed mood and urinary cortisot in the probability of having metabolic syndrome. The odds of metabolic syndrome in persons with both depressed mood and urinary cortisot excretion in the highest tertile was 1.84 (95% Cl = 1.02-3.34) compared to persons with neither condition.
   Discussion: This study suggests a synergistic relationship between depression, cortisol and metabolic syndrome. Hypercortisolemic depression may constitute a specific risk group for the metabolic syndrome. (c) 2006 Elsevier Ltd. All rights reserved.
C1 Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, NL-1081 HJ Amsterdam, Netherlands.
   Vrije Univ Amsterdam, Med Ctr, EMGO Inst, NL-1081 HJ Amsterdam, Netherlands.
   NIA, Clin Res Branch, Baltimore, MD 21224 USA.
   ASF, Florence, Italy.
   Tuscany Hlth Reg Agcy, Florence, Italy.
   NIA, Dept Epidemiol, Bethesda, MD 20892 USA.
   Univ Hosp Geneva, Dept Rehabil & Geriatr, Geneva, Switzerland.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; National
   Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA);
   National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); University of Geneva
RP Vogelzangs, N (corresponding author), Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Oldenaller 1, NL-1081 HJ Amsterdam, Netherlands.
EM nicolev@ggzba.nl
RI Ferrucci, Luigi/AED-9724-2022; Penninx, Brenda/S-7627-2017; Ble,
   Alessandro/AAV-5747-2020; bandinelli, stefania/AAL-4570-2020; Giannelli,
   Sandra/E-8637-2011; Simonsick, Eleanor/W-6864-2019; Lauretani,
   Fulvio/K-5115-2016
OI Bandinelli, Stefania/0000-0002-6491-0850; Ferrucci,
   Luigi/0000-0002-6273-1613; Lauretani, Fulvio/0000-0002-5287-9972
FU NHLBI NIH HHS [R01 HL72972-01, R01 HL072972] Funding Source: Medline;
   PHS HHS [IRTA 2300 320 7] Funding Source: Medline; Intramural NIH HHS
   [Z99 AG999999] Funding Source: Medline
CR [Anonymous], 1991, JAMA, V265, P3255
   Barrett-Connor E, 1999, J CLIN ENDOCR METAB, V84, P573, DOI 10.1210/jc.84.2.573
   Beekman ATF, 1997, PSYCHOL MED, V27, P231, DOI 10.1017/S0033291796003510
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   Björntorp P, 1999, ANN NY ACAD SCI, V892, P297, DOI 10.1111/j.1749-6632.1999.tb07803.x
   Brown LC, 2005, DIABETES CARE, V28, P1063, DOI 10.2337/diacare.28.5.1063
   Deuschle M, 1998, STRESS, V2, P281, DOI 10.3109/10253899809167292
   Eknoyan G, 2002, AM J KIDNEY DIS, V39, pS14, DOI 10.1053/ajkd.2002.30939
   FAVA GA, 1983, J CLIN PSYCHOL, V39, P249, DOI 10.1002/1097-4679(198303)39:2<249::AID-JCLP2270390218>3.0.CO;2-Y
   Ferrucci L, 1997, STROKE, V28, P2410, DOI 10.1161/01.STR.28.12.2410
   Ferrucci L, 2000, J AM GERIATR SOC, V48, P1618, DOI 10.1111/j.1532-5415.2000.tb03873.x
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Fries E, 2005, PSYCHONEUROENDOCRINO, V30, P1010, DOI 10.1016/j.psyneuen.2005.04.006
   Gold PW, 2002, MOL PSYCHIATR, V7, P254, DOI 10.1038/sj.mp.4001032
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Gur A, 2004, ARTHRITIS RES THER, V6, pR232, DOI 10.1186/ar1163
   Holsboer F, 2001, J AFFECT DISORDERS, V62, P77, DOI 10.1016/S0165-0327(00)00352-9
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Kopf D, 2004, J CLIN PSYCHOPHARM, V24, P527, DOI 10.1097/01.jcp.0000138762.23482.63
   McCaffery JM, 2003, PSYCHOSOM MED, V65, P490, DOI 10.1097/01.PSY.0000041545.52924.82
   Morrison MF, 2000, BIOL PSYCHIAT, V47, P144, DOI 10.1016/S0006-3223(99)00099-2
   Nelson JC, 1997, AM J PSYCHIAT, V154, P1497, DOI 10.1176/ajp.154.11.1497
   Oldehinkel AJ, 2001, PSYCHIAT RES, V104, P39, DOI 10.1016/S0165-1781(01)00300-6
   Otte C, 2004, BIOL PSYCHIAT, V56, P241, DOI 10.1016/j.biopsych.2004.06.003
   PENNINX BW, IN PRESS AM J GERIAT
   Penninx BWJH, 1998, AM J CARDIOL, V81, P988, DOI 10.1016/S0002-9149(98)00077-0
   Penninx BWJH, 1998, J NATL CANCER I, V90, P1888, DOI 10.1093/jnci/90.24.1888
   Penninx BWJH, 2001, ARCH GEN PSYCHIAT, V58, P221, DOI 10.1001/archpsyc.58.3.221
   Penninx BWJH, 2003, BIOL PSYCHIAT, V54, P566, DOI 10.1016/S0006-3223(02)01811-5
   Penninx BWJH, 1998, JAMA-J AM MED ASSOC, V279, P1720, DOI 10.1001/jama.279.21.1720
   Penninx BWJH, 1999, ARCH GEN PSYCHIAT, V56, P889, DOI 10.1001/archpsyc.56.10.889
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Raikkonen K, 1996, METABOLISM, V45, P1533, DOI 10.1016/S0026-0495(96)90184-5
   Räikkönen K, 2001, HYPERTENSION, V38, P798, DOI 10.1161/hyp.38.4.798
   Rosmond R, 2005, PSYCHONEUROENDOCRINO, V30, P1, DOI 10.1016/j.psyneuen.2004.05.007
   Shen BJ, 2003, AM J EPIDEMIOL, V157, P701, DOI 10.1093/aje/kwg045
   STERNBERG EM, 1992, ANN INTERN MED, V117, P854, DOI 10.7326/0003-4819-117-10-854
   Tannen RL, 2006, J CLIN EPIDEMIOL, V59, P254, DOI 10.1016/j.jclinepi.2005.08.008
   Vitaliano PP, 2002, PSYCHOSOM MED, V64, P418, DOI 10.1097/00006842-200205000-00006
   Weber-Hamann B, 2006, PSYCHONEUROENDOCRINO, V31, P347, DOI 10.1016/j.psyneuen.2005.08.014
   Weber-Hamann B, 2002, PSYCHOSOM MED, V64, P274, DOI 10.1097/00006842-200203000-00010
   Whooley MA, 2006, JAMA-J AM MED ASSOC, V295, P2874, DOI 10.1001/jama.295.24.2874
   Yudkin JS, 1999, ARTERIOSCL THROM VAS, V19, P972, DOI 10.1161/01.ATV.19.4.972
NR 44
TC 177
Z9 186
U1 0
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD FEB
PY 2007
VL 32
IS 2
BP 151
EP 159
DI 10.1016/j.psyneuen.2006.11.009
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 147FE
UT WOS:000244988000008
PM 17224244
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Yamamoto, K
   Okazaki, A
   Ohmori, S
AF Yamamoto, Kazuhiko
   Okazaki, Ai
   Ohmori, Susumu
TI The Relationship between Psychosocial Stress, Age, BMI, CRP, Lifestyle,
   and the Metabolic Syndrome in Apparently Healthy Subjects
SO JOURNAL OF PHYSIOLOGICAL ANTHROPOLOGY
LA English
DT Article
DE psychosocial stress; CRP; lifestyle; obesity; metabolic syndrome
ID C-REACTIVE PROTEIN; NUTRITION EXAMINATION SURVEY; INSULIN-RESISTANCE
   SYNDROME; TYPE-2 DIABETES-MELLITUS; CORONARY-HEART-DISEASE;
   PUBLIC-SCHOOL WORKERS; 3RD NATIONAL-HEALTH; ALCOHOL-CONSUMPTION;
   DEPRESSIVE SYMPTOMS; SEX-DIFFERENCES
AB The aim of this cross-sectional study was to examine the factors which may be associated with the metabolic syndrome by exploring the relationship between psychosocial stress, age, body mass index (HMI), C-reactive protein (CRP), lifestyle factors., and the components of the metabolic syndrome, such as glycated hemoglobin (HbA1c), fasting blood sugar (FBS), body fat percentage, and triglyceride concentration, among apparently healthy subjects. Psychosocial stress was measured by the use of the inventory to measure psychosocial stress (IMPS). One thousand four hundred and ninety-nine people out of 1,941 public school workers admitted to a hospital for a medical check-up responded to the IMPS, yielding a response rate of 77.2%. A total of 1,201 workers excluding 298 who were taking medication for various diseases were analyzed with the use of hierarchical multiple regression models. It was found that IMPS-measured stress score, age, BMI, and smoking habit were associated with an increase in glycated hemoglobin among men, while alcohol consumption was associated with a decrease in glycated hemoglobin. Stress score, age, BM1, and alcohol consumption were found to be associated with an increase in FBS among men, while smoking and exercise habits were associated with a decrease in FBS. CRP was found to be associated with an increase in body fat percentage among men, though stress score was not associated with an increase in body fat percentage. Stress score, age, and BMI were associated with an increase in triglyceride concentration among women. The findings of the present study seem to be in line with the hypothesis that psychosocial stress plays an important role in developing the metabolic syndrome, which may be associated with inflammatory processes in the vascular wall, resulting in atherosclerosis and cardiovascular disease. J Physiol Anthropol 30(1): 15-22, 2011 http://www.jstage.jst.go.jp/browse/jpa2 [DOI: 10.2114/jpa2.30.15]
C1 [Yamamoto, Kazuhiko] Kyushu Univ, Inst Hlth Sci, Minami Ku, Fukuoka 8158540, Japan.
   [Ohmori, Susumu] Kyushu Cent Hosp, Fukuoka, Japan.
C3 Kyushu University
RP Yamamoto, K (corresponding author), Kyushu Univ, Inst Hlth Sci, Minami Ku, Fukuoka 8158540, Japan.
EM yamamoto@design.kyushu-u.ac.jp
FU Japan Society for the Promotion of Science [16207018]; Grants-in-Aid for
   Scientific Research [16207018] Funding Source: KAKEN
FX This study was supported in part by a Grant-in-Aid for Scientific
   Research, No. 16207018, from the Japan Society for the Promotion of
   Science.
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Björntorp P, 1999, ANN NY ACAD SCI, V892, P297, DOI 10.1111/j.1749-6632.1999.tb07803.x
   Black PH, 2006, MED HYPOTHESES, V67, P879, DOI 10.1016/j.mehy.2006.04.008
   CHROUSOS GP, 1992, JAMA-J AM MED ASSOC, V267, P1244, DOI 10.1001/jama.267.9.1244
   Cooper DE, 2002, DIABETES CARE, V25, P1425, DOI 10.2337/diacare.25.8.1425
   Danesh J, 2004, NEW ENGL J MED, V350, P1387, DOI 10.1056/NEJMoa032804
   Davies MJ, 2002, JAMA-J AM MED ASSOC, V287, P2559, DOI 10.1001/jama.287.19.2559
   Elovainio M, 2009, PSYCHOSOM MED, V71, P423, DOI 10.1097/PSY.0b013e31819e333a
   Epel ES, 2000, PSYCHOSOM MED, V62, P623, DOI 10.1097/00006842-200009000-00005
   Ferketich AK, 2000, ARCH INTERN MED, V160, P1261, DOI 10.1001/archinte.160.9.1261
   Flegal KM, 2002, JAMA-J AM MED ASSOC, V288, P1723, DOI 10.1001/jama.288.14.1723
   Ford DE, 2004, ARCH INTERN MED, V164, P1010, DOI 10.1001/archinte.164.9.1010
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   FRANKENHAEUSER M, 1978, PSYCHOSOM MED, V40, P334, DOI 10.1097/00006842-197806000-00006
   Fuligni AJ, 2009, PSYCHOSOM MED, V71, P329, DOI 10.1097/PSY.0b013e3181921b1f
   Ginsberg HN, 2000, J CLIN INVEST, V106, P453, DOI 10.1172/JCI10762
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Grundy SM, 1999, AM J CARDIOL, V83, p25F
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Hu FB, 2001, NEW ENGL J MED, V345, P790, DOI 10.1056/NEJMoa010492
   KESSLER RC, 1984, AM SOCIOL REV, V49, P620, DOI 10.2307/2095420
   Kiechl S, 1996, BRIT MED J, V313, P1040
   Kiecolt-Glaser JK, 2003, P NATL ACAD SCI USA, V100, P9090, DOI 10.1073/pnas.1531903100
   Kroenke CH, 2003, DIABETES CARE, V26, P1971, DOI 10.2337/diacare.26.7.1971
   Kudielka BM, 2005, BIOL PSYCHOL, V69, P113, DOI 10.1016/j.biopsycho.2004.11.009
   Lutgendorf SK, 1999, J GERONTOL A-BIOL, V54, pM434, DOI 10.1093/gerona/54.9.M434
   MASTORAKOS G, 1993, J CLIN ENDOCR METAB, V77, P1690, DOI 10.1210/jc.77.6.1690
   MAYER EJ, 1993, CIRCULATION, V88, P2190, DOI 10.1161/01.CIR.88.5.2190
   McDade TW, 2006, PSYCHOSOM MED, V68, P376, DOI 10.1097/01.psy.0000221371.43607.64
   Meigs JB, 1997, DIABETES, V46, P1594, DOI 10.2337/diabetes.46.10.1594
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Raikkonen K, 1996, METABOLISM, V45, P1533, DOI 10.1016/S0026-0495(96)90184-5
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   Ridker PM, 2003, CIRCULATION, V107, P363, DOI 10.1161/01.CIR.0000053730.47739.3C
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Sesso HD, 1998, AM J CARDIOL, V82, P851, DOI 10.1016/S0002-9149(98)00491-3
   Suarez EC, 2004, PSYCHONEUROENDOCRINO, V29, P1119, DOI 10.1016/j.psyneuen.2004.01.002
   Surtees PG, 2008, PSYCHOSOM MED, V70, P850, DOI 10.1097/PSY.0b013e318183acd5
   Taubes G, 1998, SCIENCE, V280, P1367, DOI 10.1126/science.280.5368.1367
   Timonen M, 2007, PSYCHOSOM MED, V69, P723, DOI 10.1097/PSY.0b013e318157ad2e
   Tsumura K, 1999, DIABETES CARE, V22, P1432, DOI 10.2337/diacare.22.9.1432
   Wulsin LR, 2003, PSYCHOSOM MED, V65, P201, DOI 10.1097/01.PSY.0000058371.50240.E3
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yamamoto Kazuhiko, 2007, Journal of Physiological Anthropology, V26, P149, DOI 10.2114/jpa2.26.149
   Yamamoto Kazuhiko, 2009, Journal of Physiological Anthropology, V28, P129, DOI 10.2114/jpa2.28.129
   Yamamoto Kazuhiko, 2008, Journal of Physiological Anthropology, V27, P43, DOI 10.2114/jpa2.27.43
NR 50
TC 37
Z9 46
U1 0
U2 15
PU JAPAN SOC PHYSIOLOGICAL ANTHROPOLOGY
PI TOKYO
PA BUSINESS CENTER FOR ACADEMIC SOCIETIES JAPAN, 5-16-9 HONKOMAGOME, TOKYO,
   00000, JAPAN
SN 1880-6791
J9 J PHYSIOL ANTHROPOL
JI J. Physiol. Anthropol.
PD JAN
PY 2011
VL 30
IS 1
BP 15
EP 22
DI 10.2114/jpa2.30.15
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 722JH
UT WOS:000287428000003
PM 21307616
OA Bronze
DA 2025-06-11
ER

PT J
AU McCaffery, JM
   Marsland, AL
   Strohacker, K
   Muldoon, MF
   Manuck, SB
AF McCaffery, Jeanne M.
   Marsland, Anna L.
   Strohacker, Kelley
   Muldoon, Matthew F.
   Manuck, Stephen B.
TI Factor Structure Underlying Components of Allostatic Load
SO PLOS ONE
LA English
DT Article
ID INSULIN-RESISTANCE SYNDROME; CORONARY-HEART-DISEASE; GENOME-WIDE
   ASSOCIATION; METABOLIC SYNDROME; INFLAMMATORY MARKERS; RATE-VARIABILITY;
   RISK-FACTORS; SYNDROME PREDICTS; LOCI; MACARTHUR
AB Allostatic load is a commonly used metric of health risk based on the hypothesis that recurrent exposure to environmental demands (e.g., stress) engenders a progressive dysregulation of multiple physiological systems. Prominent indicators of response to environmental challenges, such as stress-related hormones, sympatho-vagal balance, or inflammatory cytokines, comprise primary allostatic mediators. Secondary mediators reflect ensuing biological alterations that accumulate over time and confer risk for clinical disease but overlap substantially with a second metric of health risk, the metabolic syndrome. Whether allostatic load mediators covary and thus warrant treatment as a unitary construct remains to be established and, in particular, the relation of allostatic load parameters to the metabolic syndrome requires elucidation. Here, we employ confirmatory factor analysis to test: 1) whether a single common factor underlies variation in physiological systems associated with allostatic load; and 2) whether allostatic load parameters continue to load on a single common factor if a second factor representing the metabolic syndrome is also modeled. Participants were 645 adults from Allegheny County, PA (30-54 years old, 82% non- Hispanic white, 52% female) who were free of confounding medications. Model fitting supported a single, second-order factor underlying variance in the allostatic load components available in this study (metabolic, inflammatory and vagal measures). Further, this common factor reflecting covariation among allostatic load components persisted when a latent factor representing metabolic syndrome facets was conjointly modeled. Overall, this study provides novel evidence that the modeled allostatic load components do share common variance as hypothesized. Moreover, the common variance suggests the existence of statistical coherence above and beyond that attributable to the metabolic syndrome.
C1 [McCaffery, Jeanne M.; Strohacker, Kelley] Brown Univ, Dept Psychiat & Human Behav, Miriam Hosp, Providence, RI 02912 USA.
   [McCaffery, Jeanne M.; Strohacker, Kelley] Brown Univ, Warren Alpert Sch Med, Providence, RI 02912 USA.
   [Marsland, Anna L.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA.
   [Muldoon, Matthew F.] Univ Pittsburgh, Sch Med, Inst Heart & Vasc, Pittsburgh, PA USA.
   [Manuck, Stephen B.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA.
C3 Lifespan Health Rhode Island; Miriam Hospital; Brown University; Brown
   University; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh
RP McCaffery, JM (corresponding author), Brown Univ, Dept Psychiat & Human Behav, Miriam Hosp, Providence, RI 02912 USA.
EM jeanne_mccaffery@brown.edu
OI McCaffery, Jeanne/0000-0002-2166-5840; Strohacker,
   Kelley/0000-0002-2067-8439
FU National Heart Lung and Blood Institute [P01HL40962]; National Institute
   of Nursing Research [NR008237]
FX This study was supported by grants P01HL40962 from the National Heart
   Lung and Blood Institute (SBM), and NR008237 from the National Institute
   of Nursing Research (ALM). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
CR [Anonymous], PSPAT PROGRAM SPECTR
   Bentler P. M., 2005, EQS structural equations program manual
   BENTLER PM, 1990, PSYCHOL BULL, V107, P238, DOI 10.1037/0033-2909.88.3.588
   BENTLER PM, 1980, PSYCHOMETRIKA, V45, P289, DOI 10.1007/BF02293905
   Bleil ME, 2008, PSYCHOSOM MED, V70, P328, DOI 10.1097/PSY.0b013e31816baefa
   Borovikova LV, 2000, NATURE, V405, P458, DOI 10.1038/35013070
   Camm AJ, 1996, CIRCULATION, V93, P1043
   Chung CM, 2011, DIABETES, V60, P2417, DOI 10.2337/db10-1321
   Dastani Z, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002607
   Dupuis J, 2010, NAT GENET, V42, P105, DOI 10.1038/ng.520
   EDWARDS KL, 1994, ARTERIOSCLER THROMB, V14, P1940, DOI 10.1161/01.ATV.14.12.1940
   Eijgelsheim M, 2010, HUM MOL GENET, V19, P3885, DOI 10.1093/hmg/ddq303
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Goldman N, 2006, J GERONTOL A-BIOL, V61, P1070, DOI 10.1093/gerona/61.10.1070
   HAFFNER SM, 1992, HYPERTENSION, V20, P38, DOI 10.1161/01.HYP.20.1.38
   Haffner SM, 2000, BRIT J NUTR, V83, pS67
   Halder I, 2010, BRAIN BEHAV IMMUN, V24, P160, DOI 10.1016/j.bbi.2009.09.014
   Hung J, 2008, INT J OBESITY, V32, P772, DOI 10.1038/sj.ijo.0803793
   Ingelsson E, 2010, DIABETES, V59, P1266, DOI [10.2337/DB09-1568, 10.2337/db09-1568]
   Janszky I, 2004, J INTERN MED, V256, P421, DOI 10.1111/j.1365-2796.2004.01403.x
   Juster RP, 2010, NEUROSCI BIOBEHAV R, V35, P2, DOI 10.1016/j.neubiorev.2009.10.002
   Karlamangla AS, 2002, J CLIN EPIDEMIOL, V55, P696, DOI 10.1016/S0895-4356(02)00399-2
   Kristiansson K, 2012, CIRC-CARDIOVASC GENE, V5, P242, DOI 10.1161/CIRCGENETICS.111.961482
   Lawlor DA, 2004, AM J EPIDEMIOL, V159, P1013, DOI 10.1093/aje/kwh150
   Lemaitre RN, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002193
   Lempiäinen P, 1999, CIRCULATION, V100, P123, DOI 10.1161/01.CIR.100.2.123
   Leu HB, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019999
   Lindblad U, 2001, AM J EPIDEMIOL, V153, P481, DOI 10.1093/aje/153.5.481
   Llabre MM, 2012, PSYCHOSOM MED, V74, P169, DOI 10.1097/PSY.0b013e3182433a30
   Manuck SB, 2010, PSYCHOSOM MED, V72, P35, DOI 10.1097/PSY.0b013e3181c484dc
   Manuck SB, 2011, DEV PSYCHOPATHOL, V23, P69, DOI 10.1017/S0954579410000659
   Marsland AL, 2010, METABOLISM, V59, P1801, DOI 10.1016/j.metabol.2010.05.015
   McCaffery Jeanne M., 2007, Metabolic Syndrome and Related Disorders, V5, P34, DOI 10.1089/met.2006.0014
   MCDONALD RP, 1990, PSYCHOL BULL, V107, P247, DOI 10.1037/0033-2909.107.2.247
   MCEWEN BS, 1993, ARCH INTERN MED, V153, P2093, DOI 10.1001/archinte.153.18.2093
   Novak S, 2003, DIABETES OBES METAB, V5, P388, DOI 10.1046/j.1463-1326.2003.00289.x
   Pladevall M, 2006, DIABETES CARE, V29, P113, DOI 10.2337/diacare.29.01.06.dc05-0862
   Pyetan E, 2003, IEEE T BIO-MED ENG, V50, P777, DOI 10.1109/TBME.2003.812158
   Pyörälä M, 2000, ARTERIOSCL THROM VAS, V20, P538, DOI 10.1161/01.ATV.20.2.538
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Reilly MP, 2003, CIRCULATION, V108, P1546, DOI 10.1161/01.CIR.0000088846.10655.E0
   Sajadieh A, 2004, EUR HEART J, V25, P363, DOI 10.1016/j.ehj.2003.12.003
   Schmidt MI, 1996, METABOLISM, V45, P699, DOI 10.1016/S0026-0495(96)90134-1
   Seeman TE, 1997, ARCH INTERN MED, V157, P2259
   Seeman TE, 2001, P NATL ACAD SCI USA, V98, P4770, DOI 10.1073/pnas.081072698
   Seeman T, 2010, ANN NY ACAD SCI, V1186, P223, DOI 10.1111/j.1749-6632.2009.05341.x
   Shen BJ, 2006, ANN EPIDEMIOL, V16, P131, DOI 10.1016/j.annepidem.2005.06.049
   Shen BJ, 2003, AM J EPIDEMIOL, V157, P701, DOI 10.1093/aje/kwg045
   Sloan RP, 2007, MOL MED, V13, P178, DOI 10.2119/2006-00112.Sloan
   Suhre K, 2011, NATURE, V477, P54, DOI 10.1038/nature10354
   Tanaka T, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000338
   Teslovich TM, 2010, NATURE, V466, P707, DOI 10.1038/nature09270
   Thayer JF, 2009, J INTERN MED, V265, P439, DOI 10.1111/j.1365-2796.2008.02023.x
   Timar O, 2000, CAN J CARDIOL, V16, P779
   Tracey KJ, 2007, J CLIN INVEST, V117, P289, DOI 10.1172/JCI30555
   Tracey KJ, 2002, NATURE, V420, P853, DOI 10.1038/nature01321
   Wang H, 2004, NAT MED, V10, P1216, DOI 10.1038/nm1124
   Wilson PWF, 1999, ARCH INTERN MED, V159, P1104, DOI 10.1001/archinte.159.10.1104
NR 58
TC 63
Z9 76
U1 0
U2 14
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 24
PY 2012
VL 7
IS 10
AR e47246
DI 10.1371/journal.pone.0047246
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 026VC
UT WOS:000310310200031
PM 23112812
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Bu, DY
   Ji, WW
   Bai, D
   Zhou, J
   Li, HX
   Yang, HF
AF Bu, De-Yun
   Ji, Wen-Wu
   Bai, Dan
   Zhou, Jian
   Li, Hai-Xia
   Yang, Hui-Fang
TI Association of Polymorphisms in Stress-Related TNFα and NPY Genes with
   the Metabolic Syndrome in Han and Hui Ethnic Groups
SO ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
LA English
DT Article
DE Metabolic syndrome; psychological stress; TNF alpha-308G/A; NPYrs16147;
   SCL; 90; Han and Hui ethnicity
ID NEUROPEPTIDE-Y; INSULIN-RESISTANCE; G-308A POLYMORPHISM; TNF-ALPHA-308
   G/A; INDUCED OBESITY; PROMOTER; EXPRESSION; RISK; INFLAMMATION; GENETICS
AB Background: Metabolic syndrome (MS) is a cluster of complicated disorders caused by the interactive influencing factors of heredity and environment, which predisposes to many cnacers. Results from epidemic research indicate that stress is tightly related to the pathogenesis of MS and neoplasia. This paper aims to investigate the association between psychological stress and MS with respect to the tumor necrosis factor alpha (TNF alpha) and neuropeptide Y (NPY) genes in the Han and Hui ethnic groups. Methods: All subjects for this case-control study matched strict enrollment criteria (nationality, gender and age) and lived in the city of Wu Zhong of Ningxia Province in China. The enrolled group contained 102 matched pairs of Hui ethnic individuals and 98 matched pairs of Han ethnic individuals. Enrolled subjects completed the general Symptom Checklist-90 (SCL-90). The TNF alpha-308G/A variant and NPYrs16147 polymorphism were detected in case (81 males, 119 females) and control (81 males, 119 females) groups by polymerase chain reaction (PCR) amplification. Results: Nine factors of the SCL-90 were found to be statistically different (p<0.05) between case and control groups. The homozygous mutant genotype (AA) and the mutant allele (A) of the TNF alpha-308G/A gene were less frequently observed in the control population compared to the case group. The odds ratio (95% confidence interval) in "Allele" for MS was 2.28 (1.47-3.53), p=0.0001, while "OR" was 1.11 (0.83-1.47), p=0.15, for the NPYrs16147 gene polymorphism. Conclusions: Psychological stress has been positively associated with MS. A previous study from our group suggested there were differences in the level of psychological stress between Hui and Han ethnic groups. Furthermore, we found that the stress-related TNF alpha gene was associated with MS for both Han and Hui ethnic groups. In contrast, NPY may be a possible contributor to MS and associated cancer for the Han ethnic group.
C1 [Bu, De-Yun; Ji, Wen-Wu; Bai, Dan; Zhou, Jian; Li, Hai-Xia; Yang, Hui-Fang] Ningxia Med Univ, Sch Publ Hlth, Yinchuan, Ningxia, Peoples R China.
C3 Ningxia Medical University
RP Yang, HF (corresponding author), Ningxia Med Univ, Sch Publ Hlth, Yinchuan, Ningxia, Peoples R China.
EM joyceyhf1968@gmail.com
FU State Natural Science Foundation of China [30860236]
FX This study was financially supported by the State Natural Science
   Foundation of China (no. 30860236). We thank Doctors Li Jun and Gao
   Xianghui of City Hospital of Wu Zhong for their administrative support
   during the execution of the study. We also thank Doctor Sun Jian of
   Yinchuan Center for Disease Control and Prevention, Ningxia, China, for
   his assistance in laboratory analysis.
CR Almadi T, 2013, PSYCHOPHYSIOLOGY, V50, P821, DOI 10.1111/psyp.12069
   Black PH, 2003, BRAIN BEHAV IMMUN, V17, P350, DOI 10.1016/S0889-1591(03)00048-5
   Bose M, 2009, CURR OPIN ENDOCRINOL, V16, P340, DOI 10.1097/MED.0b013e32832fa137
   Curti MLR, 2012, DIABETOL METAB SYNDR, V4, DOI 10.1186/1758-5996-4-49
   Dallman MF, 2010, TRENDS ENDOCRIN MET, V21, P159, DOI 10.1016/j.tem.2009.10.004
   Dalziel B, 2002, OBES RES, V10, P401, DOI 10.1038/oby.2002.55
   Ferrannini E, 2006, ANN MED, V38, P42, DOI 10.1080/07853890500415358
   Fries E, 2005, PSYCHONEUROENDOCRINO, V30, P1010, DOI 10.1016/j.psyneuen.2005.04.006
   Gallagher EJ, 2010, MT SINAI J MED, V77, P511, DOI 10.1002/msj.20212
   Gehlert DR, 1999, NEUROPEPTIDES, V33, P329, DOI 10.1054/npep.1999.0057
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Gulsun M, 2012, CURRENT APPROACHES P, V4, P14
   Gupta V, 2012, CYTOKINE, V57, P32, DOI 10.1016/j.cyto.2011.04.012
   Haefliger JA, 1999, REGUL PEPTIDES, V82, P35, DOI 10.1016/S0167-0115(99)00031-2
   Heijboer AC, 2005, PEPTIDES, V26, P2554, DOI 10.1016/j.peptides.2005.05.013
   Itokawa M, 2003, NEUROSCI LETT, V347, P202, DOI 10.1016/S0304-3940(03)00718-3
   Jermendy G, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-96
   Kalra SP, 2004, NEUROPEPTIDES, V38, P201, DOI 10.1016/j.npep.2004.06.003
   Kuo LE, 2007, NAT MED, V13, P803, DOI 10.1038/nm1611
   Kuo LE, 2008, ANN NY ACAD SCI, V1148, P232, DOI 10.1196/annals.1410.035
   Lee SC, 2000, METABOLISM, V49, P1021, DOI 10.1053/meta.2000.7704
   Li L, 2013, J ENDOCRINOL, V217, P175, DOI 10.1530/JOE-12-0559
   Li YY, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035408
   Lo J, 2007, AM J PHYSIOL-ENDOC M, V293, pE102, DOI 10.1152/ajpendo.00089.2007
   Maier W, 2000, CURR OPIN PSYCHIATR, V13, P3, DOI 10.1097/00001504-200001000-00002
   McDermott BJ, 2007, CURR TOP MED CHEM, V7, P1692, DOI 10.2174/156802607782340939
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   McGrowder DA, 2012, ASIAN PAC J CANCER P, V13, P1, DOI 10.7314/APJCP.2012.13.1.001
   Meirhaeghe A, 2005, MOL GENET METAB, V86, P293, DOI 10.1016/j.ymgme.2005.05.006
   Moller DE, 2000, TRENDS ENDOCRIN MET, V11, P212, DOI 10.1016/S1043-2760(00)00272-1
   Morales-Medina JC, 2010, BRAIN RES, V1314, P194, DOI 10.1016/j.brainres.2009.09.077
   Nobili V, 2012, PEDIAT OBES, V7, P75
   Olza J, 2013, PEPTIDES, V45, P22, DOI 10.1016/j.peptides.2013.04.007
   Ozbek E, 2014, ASIAN PAC J CANCER P, V15, P4029, DOI 10.7314/APJCP.2014.15.9.4029
   PELTONEN L, 1995, NATURE, V378, P665, DOI 10.1038/378665a0
   Rasmusson AM, 2010, EXP BIOL MED, V235, P1150, DOI 10.1258/ebm.2010.009334
   Ronco AL, 2012, ASIAN PAC J CANCER P, V13, P139, DOI 10.7314/APJCP.2012.13.1.139
   Ruohonen ST, 2009, NEUROENDOCRINOLOGY, V89, P351, DOI 10.1159/000188602
   Saukkonen T, 2012, SCAND J PRIM HEALTH, V30, P29, DOI 10.3109/02813432.2012.654192
   Song Y, 2012, NUTR METAB CARDIOVAS, V22, P456, DOI 10.1016/j.numecd.2010.09.002
   Sookoian S, 2005, AM J HYPERTENS, V18, P1271, DOI 10.1016/j.amjhyper.2005.04.014
   Sookoian SC, 2005, OBES RES, V13, P2122, DOI 10.1038/oby.2005.263
   Terán-García M, 2007, APPL PHYSIOL NUTR ME, V32, P89, DOI 10.1139/h06-102
   Trayhurn P, 2004, BRIT J NUTR, V92, P347, DOI 10.1079/BJN20041213
   van Vliet M, 2009, CARDIOVASC DIABETOL, V8, DOI 10.1186/1475-2840-8-2
   Vendrell J, 2003, ATHEROSCLEROSIS, V167, P257, DOI 10.1016/S0021-9150(02)00429-X
   Zeggini E, 2005, DIABETOLOGIA, V48, P2013, DOI 10.1007/s00125-005-1902-4
   Zhou ZF, 2008, NATURE, V452, P997, DOI 10.1038/nature06858
   ZukowskaGrojec Z, 1995, ANN NY ACAD SCI, V771, P219, DOI 10.1111/j.1749-6632.1995.tb44683.x
NR 49
TC 3
Z9 3
U1 0
U2 9
PU ASIAN PACIFIC ORGANIZATION CANCER PREVENTION
PI GYEONGGI-DO
PA APJCP HEAD OFFICE, KOREAN NATL CANCER CENTER, 323 ILAN -RO,
   ILSANDONG-GU, GOYANG-SI, GYEONGGI-DO, 410-769, SOUTH KOREA
SN 1513-7368
J9 ASIAN PAC J CANCER P
JI Asian Pac. J. Cancer Prev.
PY 2014
VL 15
IS 14
BP 5895
EP 5900
DI 10.7314/APJCP.2014.15.14.5895
PG 6
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA AR6XD
UT WOS:000343723300067
PM 25081719
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Davis, CL
   Kapuku, G
   Snieder, H
   Kumar, M
   Treiber, FA
AF Davis, CL
   Kapuku, G
   Snieder, H
   Kumar, M
   Treiber, FA
TI Insulin resistance syndrome and left ventricular mass in healthy young
   people
SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the American-Psychosomatic-Society
CY MAR 06-10, 2001
CL MONTEREY, CA
SP Amer Psychosomat Soc
DE insulin resistance; risk factors; adolescence; young adulthood; left
   ventricular hypertrophy
ID BODY-FAT DISTRIBUTION; CARDIOVASCULAR RISK; FAMILY HISTORIES; ACUTE
   STRESS; CHILDREN; HYPERTENSION; ASSOCIATION; GEOMETRY; OBESITY; ADULTS
AB Background. Findings of atherosclerotic plaques in adolescents, in the context of current epidemics of obesity and type 2 diabetes in youth, demand investigation into early cardiovascular risk development. Left ventricular hypertrophy has been linked to hypertension, obesity, and insulin resistance. Methods: Insulin resistance syndrome characteristics (fasting glucose and insulin; systolic blood pressure; waist girth) were measured in 70 normotensive, normoglycemic young people (60% male, 62% black; included 13 twin pairs; age mean +/- SD, 19 +/- 2.6 years). Left ventricular mass indexed by height(2.7) (LVMI) was obtained via ultrasound. Twin pairs were clustered to satisfy the assumption for independent observations. Results: LVMI was regressed on insulin after controlling for race, gender, and systolic blood pressure. Insulin was a significant (P = 0.02) independent predictor of LVMI (R-2 change = 0.09, P < 0.01). Waist girth accounted for an additional 4% variance of LVMI (P = 0.05). A one-factor model comprising waist (factor loading = 0.83), insulin (0.59), glucose (0.42), and LVMI (0.46) showed good fit [chi(2)(2) = 0.41, P = 0.81; root-mean-square error of approximation = 0.01. Conclusions: A subclinical metabolic syndrome is detectable early in life, before abnormal fasting glucose or high blood pressure appear. Evidence of excessive load on the heart is associated with the metabolic syndrome even after accounting for the effects of race, gender, and blood pressure. Cardiac structure seems as closely associated with this syndrome as fasting glucose level. Based on this evidence, we propose that increased left ventricular mass is a part of insulin resistance syndrome and adds to the need for preventive public health measures to improve health behaviors and cardiovascular risk status in US youth.
C1 Med Coll Georgia, Georgia Prevent Inst, Augusta, GA 30912 USA.
   Univ Miami, Sch Med, Miami, FL USA.
   St Thomas Hosp, Twin Res & Genet Epidemiol Unit, London, England.
C3 University System of Georgia; Augusta University; University of Miami;
   Guy's & St Thomas' NHS Foundation Trust
RP Med Coll Georgia, Georgia Prevent Inst, 1499 Walton Way HS1640, Augusta, GA 30912 USA.
EM cadavis@mail.mcg.edu
RI Davis, Catherine/A-7522-2011
OI Davis, Catherine Lucy/0000-0002-2942-8233; Kapuku,
   Gaston/0000-0002-0854-1413
FU NHLBI NIH HHS [HL41781, HL35073, HL56622] Funding Source: Medline
CR Barnes VA, 2001, J PSYCHOSOM RES, V51, P597, DOI 10.1016/S0022-3999(01)00261-6
   Chen W, 2000, DIABETES, V49, P1042, DOI 10.2337/diabetes.49.6.1042
   Daniels SR, 1999, CIRCULATION, V99, P541, DOI 10.1161/01.CIR.99.4.541
   Daniels SR, 2000, AM J EPIDEMIOL, V152, P1179, DOI 10.1093/aje/152.12.1179
   DEFRONZO RA, 1991, DIABETES CARE, V14, P173, DOI 10.2337/diacare.14.3.173
   DESIMONE G, 1992, J AM COLL CARDIOL, V20, P1251, DOI 10.1016/0735-1097(92)90385-Z
   DEVEREUX RB, 1977, CIRCULATION, V55, P613, DOI 10.1161/01.CIR.55.4.613
   Donahue RP, 1997, ARTERIOSCL THROM VAS, V17, P2413, DOI 10.1161/01.ATV.17.11.2413
   Fagot-Campagna A, 2000, J PEDIATR-US, V136, P664, DOI 10.1067/mpd.2000.105141
   Felicio JS, 2000, AM J HYPERTENS, V13, P1149, DOI 10.1016/S0895-7061(00)01200-0
   Ferrara L. A., 2000, American Journal of Hypertension, V13, p85A
   Flegal KM, 1999, MED SCI SPORT EXER, V31, pS509, DOI 10.1097/00005768-199911001-00004
   Galvan AQ, 2000, CIRCULATION, V102, P2233
   Gutin B, 1998, J PEDIATR-US, V132, P1023, DOI 10.1016/S0022-3476(98)70402-0
   Gutin B, 1999, AM J HUM BIOL, V11, P237, DOI 10.1002/(SICI)1520-6300(1999)11:2<237::AID-AJHB11>3.0.CO;2-9
   Hu LT, 1999, STRUCT EQU MODELING, V6, P1, DOI 10.1080/10705519909540118
   Jackson R W, 2001, Twin Res, V4, P12, DOI 10.1375/twin.4.1.12
   Kapuku GK, 1999, HYPERTENSION, V34, P1026, DOI 10.1161/01.HYP.34.5.1026
   Kuperstein R, 2000, CIRCULATION, V102, P1802
   LEVY D, 1990, NEW ENGL J MED, V322, P1561, DOI 10.1056/NEJM199005313222203
   McGill HC, 2000, CIRCULATION, V102, P374
   Mensah GA, 1999, AM J CARDIOL, V84, P583, DOI 10.1016/S0002-9149(99)00383-5
   Mokdad AH, 2000, DIABETES CARE, V23, P1278, DOI 10.2337/diacare.23.9.1278
   Murdison KA, 1998, AM J MED SCI, V315, P118, DOI 10.1097/00000441-199802000-00008
   Musante L, 1999, ASSESSMENT, V6, P225, DOI 10.1177/107319119900600303
   Palmieri V, 2001, CIRCULATION, V103, P102
   Papavassiliou DP, 1996, AM J CARDIOL, V78, P323, DOI 10.1016/0002-9149(96)00286-X
   POULIOT MC, 1994, AM J CARDIOL, V73, P460, DOI 10.1016/0002-9149(94)90676-9
   REAVEN GM, 1995, PHYSIOL REV, V75, P473, DOI 10.1152/physrev.1995.75.3.473
   Rheeder P, 1999, AM J CARDIOL, V84, P233, DOI 10.1016/S0002-9149(99)00243-X
   Rosenbloom A, 2000, DIABETES CARE, V23, P381
   Rosenbloom AL, 1999, DIABETES CARE, V22, P345, DOI 10.2337/diacare.22.2.345
   SASSON Z, 1993, CIRCULATION, V88, P1431, DOI 10.1161/01.CIR.88.4.1431
   Treiber FA, 2001, INT J PSYCHOPHYSIOL, V41, P65, DOI 10.1016/S0167-8760(00)00183-5
   TRIEBER FA, 1993, AM J HYPERTENS, V6, P505, DOI 10.1093/ajh/6.6.505
   URBINA EM, 1995, CIRCULATION, V91, P2400, DOI 10.1161/01.CIR.91.9.2400
   Urbina EM, 1999, AM HEART J, V138, P122, DOI 10.1016/S0002-8703(99)70256-5
   Verdecchia P, 1999, CIRCULATION, V100, P1802, DOI 10.1161/01.CIR.100.17.1802
   Watanabe K, 1999, J HYPERTENS, V17, P1153, DOI 10.1097/00004872-199917080-00015
NR 39
TC 47
Z9 47
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9629
EI 1538-2990
J9 AM J MED SCI
JI Am. J. Med. Sci.
PD AUG
PY 2002
VL 324
IS 2
BP 72
EP 75
DI 10.1097/00000441-200208000-00005
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC General & Internal Medicine
GA 582AM
UT WOS:000177327600004
PM 12186110
DA 2025-06-11
ER

PT J
AU Butnoriene, J
   Steibliene, V
   Saudargiene, A
   Bunevicius, A
AF Butnoriene, Jurate
   Steibliene, Vesta
   Saudargiene, Ausra
   Bunevicius, Adomas
TI Does presence of metabolic syndrome impact anxiety and depressive
   disorder screening results in middle aged and elderly individuals? A
   population based study
SO BMC PSYCHIATRY
LA English
DT Article
DE Depressive disorder; General anxiety disorder; Hospital anxiety and
   depression scale; Metabolic syndrome; Mini international
   neuropsychiatric interview; Screening
ID GENERALIZED ANXIETY; PRIMARY-CARE; HOSPITAL ANXIETY; DSM-IV; PSYCHIATRIC
   MORBIDITY; MOOD DISORDERS; FOLLOW-UP; PREVALENCE; COMORBIDITY; SCALE
AB Background: Depressive and anxiety disorders are common in primary care setting but often remain undiagnosed. Metabolic syndrome (MetS) is also prevalent in the general population and can impair recognition of common mental disorders due to significant co-morbidity and overlap with psychiatric symptoms included in self-reported depression/anxiety screening tools. We investigated if MetS has an impact on the accuracy of current major depressive disorder (MDD) and generalized anxiety disorder (GAD) screening results using the Hospital Anxiety and Depression scale (HADS).
   Methods: A total of 1115 (562 men; mean age 62.0 +/- 9.6 years) individuals of 45+ years of age were randomly selected from the general population and evaluated for current MetS; depressive and anxiety symptoms (HADS); and current MDD and GAD (Mini International Neuropsychiatric Interview [MINI]).
   Results: The MetS was diagnosed in 34.4% of the study participants. Current MDD and GAD were more common in individuals with MetS relative to individuals without MetS (25.3% vs 14.2%, respectively, p < 0.001; and 30.2% vs 20.9%, respectively, p < 0.001). The ROC analyses demonstrated that optimal thresholds of the HADS-Depression subscale for current MDE were >= 9 in individuals with MetS (sensitivity >= 87%, specificity = 73% and PPV = 52%) and >= 8 in individuals without MetS (sensitivity = 81%, specificity = 78% and PPV = 38%). At threshold of = 9 the HADS-Anxiety subscale demonstrated optimal psychometric properties for current GAD screening in individuals with MetS (sensitivity = 91%, specificity = 85% and PPV = 72%) and without MetS (sensitivity = 84%, specificity = 83% and PPV = 56%).
   Conclusions: The HADS is a reliable screening tool for current MDE and GAD in middle aged and elderly population with and without MetS. Optimal thresholds of the HADS-Depression subscale for current MDD is >= 9 for individuals with MetS and >= 8 - without MetS. Optimal threshold of the HADS-Anxiety subscale is >= 9 for current GAD in individuals with and without MetS. The presence of MetS should be considered when interpreting depression screening results.
C1 [Butnoriene, Jurate] Lithuanian Univ Hlth Sci, Inst Endocrinol, Eiveniu Str 2, LT-50161 Kaunas, Lithuania.
   [Steibliene, Vesta] Lithuanian Univ Hlth Sci, Psychiat Clin, Kaunas, Lithuania.
   [Saudargiene, Ausra] Lithuanian Univ Hlth Sci, Kaunas, Lithuania.
   [Saudargiene, Ausra; Bunevicius, Adomas] Lithuanian Univ Hlth Sci, Neurosci Inst, Kaunas, Lithuania.
C3 Lithuanian University of Health Sciences; Lithuanian University of
   Health Sciences; Lithuanian University of Health Sciences; Lithuanian
   University of Health Sciences
RP Butnoriene, J (corresponding author), Lithuanian Univ Hlth Sci, Inst Endocrinol, Eiveniu Str 2, LT-50161 Kaunas, Lithuania.
EM jurate.butnoriene@fc.lsmuni.lt
RI Bunevicius, Adomas/I-3394-2019; Steibliene, Vesta/I-6517-2019
OI Bunevicius, Adomas/0000-0003-0446-6898; Steibliene,
   Vesta/0000-0002-8374-2768
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   ALLABY M, 2010, REVISED REPORT SCREE
   Andrews G, 2010, DEPRESS ANXIETY, V27, P134, DOI 10.1002/da.20658
   [Anonymous], J CLIN PSYCHIAT
   [Anonymous], 1996, Guide to clinical preventive services, V2nd ed
   [Anonymous], DSM 4 TR DIAGN STAT
   Berard RMF, 1998, PSYCHO-ONCOL, V7, P112, DOI 10.1002/(SICI)1099-1611(199803/04)7:2<112::AID-PON300>3.3.CO;2-N
   Bjelland I, 2002, J PSYCHOSOM RES, V52, P69, DOI 10.1016/S0022-3999(01)00296-3
   Botega NJ, 1995, REV SAUDE PUBL, V29, P355, DOI 10.1590/S0034-89101995000500004
   Bunevicius A, 2007, DEPRESS ANXIETY, V24, P455, DOI 10.1002/da.20274
   Bunevicius A, 2013, HEALTH QUAL LIFE OUT, V11, DOI 10.1186/1477-7525-11-37
   Bunevicius A, 2012, J PSYCHOSOM RES, V72, P22, DOI 10.1016/j.jpsychores.2011.10.006
   Bunevicius R, 2014, SCAND J PRIM HEALTH, V32, P24, DOI 10.3109/02813432.2013.873604
   Butnoriene J, 2015, INT J CARDIOL, V190, P360, DOI 10.1016/j.ijcard.2015.04.122
   Butnoriene J, 2014, PSYCHONEUROENDOCRINO, V40, P269, DOI 10.1016/j.psyneuen.2013.11.002
   Carroll D, 2009, BIOL PSYCHIAT, V66, P91, DOI 10.1016/j.biopsych.2009.02.020
   Combs H, 2014, MED CLIN N AM, V98, P1007, DOI 10.1016/j.mcna.2014.06.003
   Cougle JR, 2009, J PSYCHIATR RES, V43, P825, DOI 10.1016/j.jpsychires.2008.12.004
   Culpepper L, 2002, J CLIN PSYCHIAT, V63, P35
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   ELRUFAIE OEF, 1995, SOC PSYCH PSYCH EPID, V30, P26, DOI 10.1007/BF00784431
   Freeman A, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-3638-0
   García-Campayo J, 2015, PREV MED, V76, pS12, DOI 10.1016/j.ypmed.2014.10.015
   Genuth S, 2003, DIABETES CARE, V26, P3160
   Gonen M, 2007, ANAL RECEIVER OPERAT, P25
   Hawgood J, 2008, CURR OPIN PSYCHIATR, V21, P51, DOI 10.1097/YCO.0b013e3282f2309d
   Haworth JE, 2007, INT J GERIATR PSYCH, V22, P1147, DOI 10.1002/gps.1807
   Heiskanen TH, 2006, J CLIN PSYCHIAT, V67, P1422, DOI 10.4088/JCP.v67n0913
   HOPWOOD P, 1991, BRIT J CANCER, V64, P353, DOI 10.1038/bjc.1991.305
   Joffres M, 2013, CAN MED ASSOC J, V185, P775, DOI 10.1503/cmaj.130403
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Katon W, 2007, ANN INTERN MED, V146, P390, DOI 10.7326/0003-4819-146-5-200703060-00011
   Katsuki A, 2001, DIABETES CARE, V24, P362, DOI 10.2337/diacare.24.2.362
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kessler RC, 2002, J HEALTH SOC BEHAV, V43, P171, DOI 10.2307/3090195
   Kessler RC, 2001, PSYCHIAT CLIN N AM, V24, P19, DOI 10.1016/S0193-953X(05)70204-5
   Kessler RC, 2005, ARCH GEN PSYCHIAT, V62, P593, DOI 10.1001/archpsyc.62.6.593
   KESSLER RC, 1994, ARCH GEN PSYCHIAT, V51, P8
   Kroenke K, 2007, ANN INTERN MED, V146, P317, DOI 10.7326/0003-4819-146-5-200703060-00004
   Lecrubier Y, 2007, J CLIN PSYCHIAT, V68, P36
   Martin CR, 2008, J EVAL CLIN PRACT, V14, P281, DOI 10.1111/j.1365-2753.2007.00850.x
   Martinac M, 2014, ACTA CLIN CROAT, V53, P55
   Miettola J, 2008, SCAND J PRIM HEALTH, V26, P203, DOI 10.1080/02813430802117624
   Morriss RK, 1998, J ROY SOC MED, V91, P365, DOI 10.1177/014107689809100706
   Munk-Jorgensen P, 2006, PSYCHIAT SERV, V57, P1738, DOI 10.1176/appi.ps.57.12.1738
   National Institute for Health and Clinical Excellence: Guidance, 2010, DEPR TREATM MAN DEPR
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pi-Sunyer FX, 1998, OBES RES, V6, p51S
   Procopiou Michel, 2005, Cerebrovasc Dis, V20 Suppl 1, P2, DOI 10.1159/000088231
   Qin XX, 2008, J AFFECT DISORDERS, V110, P46, DOI 10.1016/j.jad.2007.12.237
   RAZAVI D, 1992, EUR J CANCER, V28A, P1869, DOI 10.1016/0959-8049(92)90025-W
   Remus JL, 2015, BEHAV NEUROSCI, V129, P321, DOI 10.1037/bne0000056
   Rickels K, 2001, J CLIN PSYCHIAT, V62, P4
   Roberge P, 2015, BMC FAM PRACT, V16, DOI 10.1186/s12875-015-0358-y
   Roy-Byrne PP, 2004, J CLIN PSYCHIAT, V65, P20
   SARTORIUS N, 1993, ARCH GEN PSYCHIAT, V50, P819
   Sheehan DV, 1998, J CLIN PSYCHIAT, V59, P22, DOI 10.4088/JCP.09m05305whi
   Simon G E, 1995, Arch Fam Med, V4, P99, DOI 10.1001/archfami.4.2.99
   Siu AL, 2016, JAMA-J AM MED ASSOC, V315, P380, DOI 10.1001/jama.2015.18392
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Spinhoven P.H., 1997, PSCYHOL MED, V27, P263
   Stein MB, 2004, AM J PSYCHIAT, V161, P2230, DOI 10.1176/appi.ajp.161.12.2230
   Stein MB, 2004, J CLIN PSYCHIAT, V65, P3
   Strauss RS, 2000, PEDIATRICS, V105, part. no., DOI 10.1542/peds.105.1.e15
   Thombs BD, 2014, BMJ-BRIT MED J, V348, DOI 10.1136/bmj.g1253
   Tziallas Dimitrios, 2011, BMC Res Notes, V4, P105, DOI 10.1186/1756-0500-4-105
   US Preventive Serv Task Force, 2009, ANN INTERN MED, V151, P784, DOI 10.7326/0003-4819-151-11-200912010-00006
   van Vliet-Ostaptchouk JV, 2014, BMC ENDOCR DISORD, V14, DOI 10.1186/1472-6823-14-9
   Wittchen HU, 2002, J CLIN PSYCHIAT, V63, P24
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 71
TC 12
Z9 13
U1 0
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD JAN 8
PY 2018
VL 18
AR 5
DI 10.1186/s12888-017-1576-8
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FS2SL
UT WOS:000419628700003
PM 29310620
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Marijnissen, RM
   Smits, JEMP
   Schoevers, RA
   van den Brink, RHS
   Holewijn, S
   Franke, B
   de Graaf, J
   Voshaar, RCO
AF Marijnissen, Radboud M.
   Smits, Johanna E. M. P.
   Schoevers, Robert A.
   van den Brink, Rob H. S.
   Holewijn, Suzanne
   Franke, Barbara
   de Graaf, Jacqueline
   Voshaar, Richard C. Oude
TI Association between metabolic syndrome and depressive symptom
   profiles-Sex-specific?
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Metabolic syndrome X; Aged; Adiponectin
ID ADIPONECTIN; INFLAMMATION; WOMEN; POPULATION; DIMENSIONS; OBESITY; HEART
AB Background: The association between depression and metabolic syndrome is becoming more obvious. Waist circumference (WC) might be the most important metabolic syndrome (MetS) feature in relation to late-life depression, with a possible mediating role for adiponectin.
   Methods: Cross-sectional population based survey of 1277 participants (50-70 years). We measured all components of MetS, plasma adiponectin levels and depressive symptoms using Beck Depression Inventory (BDI). Principal components analysis on the BDI items revealed two factors, representing a cognitive-affective and a somatic-affective symptom-cluster. Multiple linear regression models with the BDI sum score and both depression symptom-clusters as dependent variables, respectively, were used to examine the association with each component of metabolic syndrome adjusted for confounders. We explored sex-differences as well as a hypothesised mediating effect of adiponectin.
   Results: The presence of MetS as well as number of metabolic risk factors were significantly associated with BDI sum score. In men WC, triglycerides and HDL cholesterol explained variance in depressive symptoms, whereas in women this effect was confined to WC. Moreover, irrespective of sex, all associations were primarily driven by the somatic-affective symptom cluster, Adiponectin neither mediated nor moderated any of the associations found.
   Limitations: Cross-sectional design limits causal interpretation. Being a population based survey, some selection bias might have occurred toward healthier part of population.
   Conclusions: Although pathophysiological mechanisms underlying the association between metabolic disturbances and depression remains to be elucidated, our study points to sex differences as well as a specific phenotype of depression that is associated with metabolic disturbances. (C) 2013 Elsevier B.V. All rights reserved
C1 [Marijnissen, Radboud M.; Smits, Johanna E. M. P.] Pro Persona, Dept Old Age Psychiat, Wolfheze Arnhem, Netherlands.
   [Marijnissen, Radboud M.; Schoevers, Robert A.; van den Brink, Rob H. S.; Voshaar, Richard C. Oude] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands.
   [Holewijn, Suzanne; de Graaf, Jacqueline] Radboud Univ Nijmegen, Med Ctr, Div Vasc Med, Dept Gen Internal Med, NL-6525 ED Nijmegen, Netherlands.
   [Franke, Barbara] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6525 ED Nijmegen, Netherlands.
   [Franke, Barbara] Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, NL-6525 ED Nijmegen, Netherlands.
C3 University of Groningen; Radboud University Nijmegen; Radboud University
   Nijmegen; Radboud University Nijmegen
RP Marijnissen, RM (corresponding author), Pro Persona, Dept Old Age Psychiat, Wolfheze 2, NL-6874 BE Wolfheze, Gelderland, Netherlands.
EM r.marijnissen@propersona.nl
RI de Graaf, J./H-8038-2014; Franke, Barbara/D-4836-2009
OI Oude Voshaar, Richard/0000-0003-1501-4774; Holewijn,
   Suzanne/0000-0001-7641-1322; Franke, Barbara/0000-0003-4375-6572;
   Schoevers, Robert A/0000-0003-0760-9866
FU Dutch Scientific Organisation (ZonMw) [90700231]
FX R.C. Oude Voshaar is research fellow of the Dutch Scientific
   Organisation (ZonMw) (Research Grant 90700231).
CR Akbaraly TN, 2011, DIABETES CARE, V34, P904, DOI 10.2337/dc10-1644
   Ancelin ML, 2010, BIOL PSYCHIAT, V68, P125, DOI 10.1016/j.biopsych.2010.04.011
   [Anonymous], J OBES
   Baden M.Y., 2012, CLIN ENDOCRINOLOGY
   Beck A. T., 1987, Beck depression inventory
   Bus BAA, 2011, PSYCHOL MED, V41, P1419, DOI 10.1017/S0033291710002151
   Cheng Y, 2010, PHYS RES TECHNOL, P1
   Cizza G, 2010, J CLIN PSYCHIAT, V71, P1079, DOI 10.4088/JCP.09m05314blu
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   de Jonge P, 2006, AM J PSYCHIAT, V163, P138, DOI 10.1176/appi.ajp.163.1.138
   Diniz BS, 2012, J PSYCHIATR RES, V46, P1081, DOI 10.1016/j.jpsychires.2012.04.028
   Duivis HE, 2013, PSYCHONEUROENDOCRINO, V38, P1573, DOI 10.1016/j.psyneuen.2013.01.002
   Gale CR, 2010, BIOL PSYCHIAT, V67, P189, DOI 10.1016/j.biopsych.2009.09.019
   Hamer M, 2012, MOL PSYCHIATR, V17, P940, DOI 10.1038/mp.2012.30
   Holewijn S, 2010, J INTERN MED, V267, P588, DOI 10.1111/j.1365-2796.2009.02192.x
   Hoogendoorn EH, 2006, CLIN CHEM, V52, P104, DOI 10.1373/clinchem.2005.055194
   Jeong HG, 2012, PSYCHONEUROENDOCRINO, V37, P948, DOI 10.1016/j.psyneuen.2011.11.002
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178, DOI 10.4088/JCP.v69n0202
   Lehto SM, 2010, ACTA PSYCHIAT SCAND, V121, P209, DOI 10.1111/j.1600-0447.2009.01463.x
   Linke SE, 2009, ARCH GEN PSYCHIAT, V66, P499, DOI 10.1001/archgenpsychiatry.2009.27
   Marijnissen RM, 2011, J AM GERIATR SOC, V59, P67, DOI 10.1111/j.1532-5415.2010.03228.x
   Mathieu P, 2009, HYPERTENSION, V53, P577, DOI 10.1161/HYPERTENSIONAHA.108.110320
   Matsuzawa Y, 2011, J ATHEROSCLER THROMB, V18, P629, DOI 10.5551/jat.7922
   Pan A, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001392
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Roest AM, 2011, J AFFECT DISORDERS, V131, P158, DOI 10.1016/j.jad.2010.11.018
   Roger VL, 2012, CIRCULATION, V125, pE2, DOI [10.1161/CIR.0b013e31823ac046, 10.1161/CIR.0b013e3182456d46]
   Schwartz T L, 2004, Obes Rev, V5, P233, DOI 10.1111/j.1467-789X.2004.00149.x
   Simon GE, 2008, GEN HOSP PSYCHIAT, V30, P32, DOI 10.1016/j.genhosppsych.2007.09.001
   Stampfer MJ, 2000, NEW ENGL J MED, V343, P16, DOI 10.1056/NEJM200007063430103
   Sutin AR, 2010, J AFFECT DISORDERS, V127, P241, DOI 10.1016/j.jad.2010.06.004
   Tedders SH, 2011, J AFFECT DISORDERS, V135, P115, DOI 10.1016/j.jad.2011.06.045
   Thombs BD, 2010, BRIT J PSYCHIAT, V197, P61, DOI 10.1192/bjp.bp.109.076596
   van der Leeuw J, 2013, MENOPAUSE, V20, P409, DOI 10.1097/gme.0b013e31827212a5
   Vogelzangs N, 2011, J CLIN PSYCHIAT, V72, P598, DOI 10.4088/JCP.10m06559
   Wilhelm CJ, 2013, PHARMACOL BIOCHEM BE, V103, P643, DOI 10.1016/j.pbb.2012.11.001
   Zeugmann S, 2010, J CLIN PSYCHIAT, V71, P1007, DOI 10.4088/JCP.08m04767blu
NR 37
TC 30
Z9 31
U1 0
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD DEC
PY 2013
VL 151
IS 3
BP 1138
EP 1142
DI 10.1016/j.jad.2013.07.029
PG 5
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 241OC
UT WOS:000326175500047
PM 24011730
DA 2025-06-11
ER

PT J
AU Malas, O
   Muja, A
   Balada, F
   Urieta, P
   Worner, F
AF Malas, Olga
   Muja, Anton
   Balada, Ferran
   Urieta, Patricia
   Worner, Fernando
TI Psychological risk factors for metabolic syndrome: re-exploring the link
SO ANUARIO DE PSICOLOGIA
LA English
DT Article
DE metabolic syndrome (MetS); alexithymia; type A behavior; type D
   personality; anxiety; depression; somatization
ID CORONARY-HEART-DISEASE; TORONTO-ALEXITHYMIA-SCALE; ANGER EXPRESSION;
   PROVISIONAL REPORT; DIABETES-MELLITUS; BLOOD-PRESSURE; D PERSONALITY;
   TRAIT ANGER; DEPRESSION; ASSOCIATION
AB This study re-explores the relationship between metabolic syndrome (MetS), according to IDF and NCEP criteria, and personality and psychopathological variables. We studied trait anger, type A behavior, type D personality, alexithymia, Zuckerman's personality dimensions, anxiety, somatization, depression, and hostility. The sample was 410 males (M-age = 52.54, SD = 10.43). A cross-sectional design was used age with self-report data from questionnaires and biological measures. Participants completed the type D scale (DS14), the Jenkins Activity Survey (JAS), the Toronto Alexithymia Scale (TAS-20), the State-Trait Anger Expression Inventory-2 (STAXI-2), the Brief Symptom Inventory (BSI) and the shortened cross-cultural Zuckerman-Kuhlman Personality Questionnaire (ZKPQ-50-CC). The results show that subjects with IDF/NCEP criteria have significantly high scores in anxiety/negative affect, aggression-hostility, trait anger, alexithymia, negative affect, somatization, depression, and anxiety, but not in type A. No differences were found between both MetS criteria. High scores in somatization, difficulty in describing feelings, impulsive sensation seeking, and low scores in activity predict a small, but significant, part of the variance of systolic pressure, HDC cholesterol, triglycerides, glucose, and waist circumference. This study provides certain evidence for an association between MetS and psychological variables, including psychopathological symptoms, according to IDF and NCEP criteria.
C1 [Malas, Olga; Muja, Anton; Urieta, Patricia] Univ Lleida, Catalonia, Spain.
   [Malas, Olga; Muja, Anton; Balada, Ferran; Urieta, Patricia; Worner, Fernando] Dr Pifarre Fdn IRBLIeida, Lleida Inst Biomed Res, Catalonia, Spain.
   [Muja, Anton] Avda Estudi Gen 4, Lleida 25001, Spain.
   [Balada, Ferran] Autonomous Univ Barcelona, Dept Psychobiol & Methodol Hlth Sci, Catalonia, Spain.
   [Worner, Fernando] Hosp Arnau de Vilanova Lleida, Cardiol Serv, Catalonia, Spain.
C3 Universitat de Lleida; Autonomous University of Barcelona
RP Muja, A (corresponding author), Univ Lleida, Catalonia, Spain.; Muja, A (corresponding author), Dr Pifarre Fdn IRBLIeida, Lleida Inst Biomed Res, Catalonia, Spain.; Muja, A (corresponding author), Avda Estudi Gen 4, Lleida 25001, Spain.
EM anton.aluja@udl.cat
RI Urieta, Patricia/AAZ-3177-2020; Balada, Ferran/C-5570-2008; Aluja,
   Anton/A-7588-2008; Malas, Olga/AAE-6943-2021
OI TOLSA, MARIA DOLORES/0000-0001-5803-2716; Aluja,
   Anton/0000-0002-7865-0287; Balada, Ferran/0000-0001-7406-0135; Malas,
   Olga/0000-0002-9861-198X
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Allen SF, 2019, PSYCHOL HEALTH, V34, P773, DOI 10.1080/08870446.2019.1568431
   Almas A, 2017, BMC CARDIOVASC DISOR, V17, DOI 10.1186/s12872-017-0604-4
   Aluja A, 2005, EUR J PSYCHOL ASSESS, V21, P67, DOI 10.1027/1015-5759.21.1.67
   Aluja A, 2007, PERS INDIV DIFFER, V43, P2294, DOI 10.1016/j.paid.2007.07.019
   Aluja A, 2007, J PERS ASSESS, V88, P246, DOI 10.1080/00223890701268116
   Aluja A, 2019, PERS INDIV DIFFER, V142, P301, DOI 10.1016/j.paid.2018.08.011
   BAGBY RM, 1994, J PSYCHOSOM RES, V38, P33, DOI 10.1016/0022-3999(94)90006-X
   BAGBY RM, 1994, J PSYCHOSOM RES, V38, P23, DOI 10.1016/0022-3999(94)90005-1
   Balkau B, 1999, DIABETIC MED, V16, P442
   Boylan JM, 2015, J GERONTOL B-PSYCHOL, V70, P77, DOI 10.1093/geronb/gbt092
   Butnoriene J, 2014, PSYCHONEUROENDOCRINO, V40, P269, DOI 10.1016/j.psyneuen.2013.11.002
   Chida Y, 2009, J AM COLL CARDIOL, V53, P936, DOI 10.1016/j.jacc.2008.11.044
   Cohen BE, 2010, PSYCHIAT RES, V175, P133, DOI 10.1016/j.psychres.2009.02.004
   Cohen J., 1988, STAT POWER ANAL BEHA, DOI [10.4324/9780203771587, DOI 10.4324/9780203771587]
   De Berardis D, 2013, COMPR PSYCHIAT, V54, P517, DOI 10.1016/j.comppsych.2012.12.013
   Deary IJ, 1997, PERS INDIV DIFFER, V22, P551, DOI 10.1016/S0191-8869(96)00229-2
   Denollet J, 2005, PSYCHOSOM MED, V67, P89, DOI 10.1097/01.psy.0000149256.81953.49
   Denollet J, 1996, LANCET, V347, P417, DOI 10.1016/S0140-6736(96)90007-0
   Derogatis L., 1975, PSYCHOPATHOLOGY, V27, P14, DOI [DOI 10.1016/S0191-8869(96)00229-2, 10.1016/S0191-8869(96) 00229-2]
   Elovainio M, 2011, BIOL PSYCHOL, V87, P234, DOI 10.1016/j.biopsycho.2011.03.002
   Epifanio MS, 2018, FRONT PSYCHOL, V9, DOI 10.3389/fpsyg.2018.00106
   Everson SA, 1999, STROKE, V30, P523, DOI 10.1161/01.STR.30.3.523
   Fernandez-Abascal E., 1992, INVENTARIO ACTIVIDAD
   FRIEDMAN M, 1959, JAMA-J AM MED ASSOC, V169, P1286, DOI 10.1001/jama.1959.03000290012005
   Friedman M., 1996, TYPE BEHAV ITS DIAGN
   Garcia LF, 2010, PSYCHIAT RES, V177, P161, DOI 10.1016/j.psychres.2008.12.018
   Goldbacher EM, 2007, ANN BEHAV MED, V34, P240, DOI 10.1007/BF02874549
   Grabe HJ, 2010, J PSYCHOSOM RES, V68, P139, DOI 10.1016/j.jpsychores.2009.07.015
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Helmers KF, 1999, J PSYCHOSOM RES, V47, P635, DOI 10.1016/S0022-3999(99)00067-7
   Hildrum B, 2009, ACTA PSYCHIAT SCAND, V120, P14, DOI 10.1111/j.1600-0447.2008.01315.x
   HORN JL, 1965, PSYCHOMETRIKA, V30, P179, DOI 10.1007/BF02289447
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Ikeda A, 2008, INT J EPIDEMIOL, V37, P1395, DOI 10.1093/ije/dyn124
   JENKINS CD, 1971, PSYCHOSOM MED, V33, P193, DOI 10.1097/00006842-197105000-00001
   Karukivi M, 2016, PSYCHIAT RES, V236, P58, DOI 10.1016/j.psychres.2015.12.034
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Lemche AV, 2014, PSYCHIAT RES, V215, P438, DOI 10.1016/j.psychres.2013.12.004
   Lemche AV, 2014, INT J CARDIOL, V171, pE76, DOI 10.1016/j.ijcard.2013.11.101
   Luppino FS, 2011, PSYCHOSOM MED, V73, P257, DOI 10.1097/PSY.0b013e31820a59c0
   Mart��nez-S��nchez F., 1996, Clinica y Salud, V7, P19
   MATTHEWS KA, 1988, PSYCHOL BULL, V104, P373, DOI 10.1037/0033-2909.104.3.373
   Miguel-Tobal J.J., 2001, Inventario de Expresion de la Ira Estado-Rasgo
   Mommersteeg PMC, 2012, J PSYCHOSOM RES, V73, P326, DOI 10.1016/j.jpsychores.2012.08.019
   Mommersteeg PMC, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-714
   Müller J, 2003, J PSYCHOSOM RES, V55, P561, DOI 10.1016/S0022-3999(03)00033-3
   Myrtek M, 2001, INT J CARDIOL, V79, P245, DOI 10.1016/S0167-5273(01)00441-7
   Niaura R., 2002, HLTH PSYCHOL, V21
   Ohseto H, 2018, J PSYCHOSOM RES, V107, P20, DOI 10.1016/j.jpsychores.2018.01.013
   Ortega Y, 2018, PRIM CARE DIABETES, V12, P163, DOI 10.1016/j.pcd.2017.09.002
   ROSENMAN RH, 1975, JAMA-J AM MED ASSOC, V233, P872, DOI 10.1001/jama.233.8.872
   Ruipérez MA, 2001, EUR J PSYCHOL ASSESS, V17, P241, DOI 10.1027//1015-5759.17.3.241
   Schum JL, 2003, J BEHAV MED, V26, P395, DOI 10.1023/A:1025767900757
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Spielberger C.D., 1988, MANUAL STATE TRAIT A
   Stingl M., 2018, Interventions Obes Diabetes, V1, P1, DOI [10.31031/IOD, DOI 10.31031/IOD, DOI 10.31031/IOD.2018.01.000512]
   SULS J, 1995, HEALTH PSYCHOL, V14, P444, DOI 10.1037/0278-6133.14.5.444
   Sutin AR, 2010, AGE, V32, P513, DOI 10.1007/s11357-010-9153-9
   Svansdottir E, 2013, EUR J PREV CARDIOL, V20, P322, DOI 10.1177/2047487312441723
   Todaro JF, 2005, AM J CARDIOL, V96, P221, DOI 10.1016/j.amjcard.2005.03.049
   Toker S, 2008, DEPRESS ANXIETY, V25, P661, DOI 10.1002/da.20379
   Tziallas Dimitrios, 2011, BMC Res Notes, V4, P105, DOI 10.1186/1756-0500-4-105
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
   Zimmet P, 2005, J ATHEROSCLER THROMB, V12, P295, DOI 10.5551/jat.12.295
   ZYZANSKI SJ, 1976, ARCH INTERN MED, V136, P1234, DOI 10.1001/archinte.136.11.1234
NR 68
TC 0
Z9 0
U1 0
U2 5
PU UNIV BARCELONA, FAC PSICOLOGIA
PI BARCELONA
PA PASSEIG DE LA VALL DE HEBRON 171, BARCELONA, 08035, SPAIN
SN 0066-5126
EI 1988-5253
J9 ANU PSICOL
JI Anu. Psicol.
PY 2020
VL 50
IS 2
BP 66
EP 78
DI 10.1344/ANPSIC2020.50.6
PG 13
WC Psychology; Psychology, Multidisciplinary
WE Emerging Sources Citation Index (ESCI)
SC Psychology
GA ML6FJ
UT WOS:000549559200003
DA 2025-06-11
ER

PT J
AU Nussbaumerova, B
   Rosolova, H
   Krizek, M
   Sefrna, F
   Racek, J
   Müller, L
   Sindberg, C
AF Nussbaumerova, Barbora
   Rosolova, Hana
   Krizek, Miroslav
   Sefrna, Frantisek
   Racek, Jaroslav
   Muller, Ludek
   Sindberg, Christian
TI Chromium Supplementation Reduces Resting Heart Rate in Patients with
   Metabolic Syndrome and Impaired Glucose Tolerance
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Metabolic syndrome; Impaired glucose tolerance; Chromium yeast
ID DIABETES-MELLITUS; CARDIOVASCULAR-DISEASES; OXIDATIVE STRESS; INSULIN;
   PICOLINATE; PLASMA; TRIAL
AB Chromium (Cr) is considered as an important mineral, involved in biochemical reactions in human metabolic pathways. Organically bound Cr supplementation has been suggested to improve glycemia especially in patients with type 2 diabetes mellitus, but there are conflicting reports on efficacy. Effect of Cr is not clear in prediabetes status. Seventy patients with metabolic syndrome and impaired glucose tolerance (IGT), who are observed and treated in the Center of Preventive Cardiology of the University Hospital in Pilsen, were included in the prospective, randomized, double-blind, and placebo-controlled clinical study. Effect of Cr-enriched yeast (200 mu g of elementary Cr in the morning and 100 mu g in the evening) on glucose, lipid metabolism, fat tissue hormones, oxidative stress, and DNA damage markers was analyzed. There were no significant changes in glucose and lipid parameters, oxidative stress, or other laboratory markers. Only resting heart rate was significantly reduced in patients treated by Cr yeast, reflecting reduced sympathetic activity. This could represent an important cardiovascular risk reduction in patients with high cardiometabolic risk.
C1 [Nussbaumerova, Barbora; Rosolova, Hana; Krizek, Miroslav; Sefrna, Frantisek] Charles Univ Prague, Med Fac Pilsen, Med Dept 2, Ctr Prevent Cardiol, Plzen, Czech Republic.
   [Nussbaumerova, Barbora; Rosolova, Hana; Krizek, Miroslav; Sefrna, Frantisek; Racek, Jaroslav] Charles Univ Prague, Fac Hosp, Plzen, Czech Republic.
   [Racek, Jaroslav] Charles Univ Prague, Med Fac Pilsen, Inst Clin Biochem & Hematol, Plzen, Czech Republic.
   [Muller, Ludek] Univ West Bohemia, Fac Sci Appl, European Ctr Excellence, New Technol Informat Soc, Plzen, Czech Republic.
   [Sindberg, Christian] Pharma Nord ApS, Res Dept, Vejle, Denmark.
C3 Charles University Prague; Charles University Prague; Charles University
   Prague; University of West Bohemia Pilsen
RP Sindberg, C (corresponding author), Pharma Nord ApS, Res Dept, Vejle, Denmark.
EM cdsindberg@pharmanord.com
RI Muller, Ludek/I-1617-2016
OI Muller, Ludek/0000-0002-6581-6348
FU Charles University Research Grant
FX Christian Sindberg, M.Sc., is an empolyee of Research Department, Pharma
   Nord ApS, Vejle, Denmark. Pharma Nord, Denmark, provided placebo, Cr
   tablets, and glucose solutions for oGTT. However, no monies were
   received from Pharma Nord. Laboratory methods were supported by the
   Charles University Research Grant (Medical Faculty in Pilsen P-36).
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Ali A, 2011, ENDOCR PRACT, V17, P16, DOI 10.4158/EP10131.OR
   [Anonymous], 2001, DIETARY REFERENCE IN
   Ashoush S, 2016, J OBSTET GYNAECOL RE, V42, P279, DOI 10.1111/jog.12907
   Bailey CH, 2014, BIOL TRACE ELEM RES, V157, P1, DOI 10.1007/s12011-013-9863-9
   Balk EM, 2007, DIABETES CARE, V30, P2154, DOI 10.2337/dc06-0996
   Cefalu WT, 2004, DIABETES CARE, V27, P2741, DOI 10.2337/diacare.27.11.2741
   Dobiásová M, 2004, CLIN CHEM, V50, P1113, DOI 10.1373/clinchem.2004.033175
   Fiorentino TV, 2013, CURR PHARM DESIGN, V19, P5695, DOI 10.2174/1381612811319320005
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Gunton JE, 2005, DIABETES CARE, V28, P712, DOI 10.2337/diacare.28.3.712
   Iqbal N, 2009, METAB SYNDR RELAT D, V7, P143, DOI 10.1089/met.2008.0048
   Jeejeebhoy KN, 1999, NUTR REV, V57, P329, DOI 10.1111/j.1753-4887.1999.tb06909.x
   Jentzsch AM, 1996, FREE RADICAL BIO MED, V20, P251, DOI 10.1016/0891-5849(95)02043-8
   Kalousová M, 2002, PHYSIOL RES, V51, P597, DOI 10.33549/physiolres.930234
   Levy JC, 1998, DIABETES CARE, V21, P2191, DOI 10.2337/diacare.21.12.2191
   MAHDI GS, 1995, J AM DIET ASSOC, V95, P749, DOI 10.1016/S0002-8223(95)00206-5
   Mancia G, 1998, SCAND CARDIOVASC J, V32, P9, DOI 10.1080/140174398427992
   McIver DJ, 2015, J NUTR, V145, P2675, DOI 10.3945/jn.115.214569
   Osterberg L, 2005, NEW ENGL J MED, V353, P487, DOI 10.1056/NEJMra050100
   Racek J, 2013, BIOL TRACE ELEM RES, V155, P1, DOI 10.1007/s12011-013-9758-9
   Reaven GM, 1996, NEW ENGL J MED, V334, P374, DOI 10.1056/NEJM199602083340607
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Rosolova H, 1999, CAS LEK CES, V137, P80
   Rydén L, 2013, EUR HEART J, V34, P3035, DOI 10.1093/eurheartj/eht108
   Sreekanth R, 2008, BIOCHEM BIOPH RES CO, V369, P725, DOI 10.1016/j.bbrc.2008.02.083
   Vincent JB, 2014, J TRACE ELEM MED BIO, V28, P397, DOI 10.1016/j.jtemb.2014.06.020
   WALLACH S, 1985, J AM COLL NUTR, V4, P107
   Wang ZQ, 2010, CURR DIABETES REP, V10, P145, DOI 10.1007/s11892-010-0097-3
   Wiernsperger N, 2010, DIABETOL METAB SYNDR, V2, DOI 10.1186/1758-5996-2-70
NR 30
TC 24
Z9 24
U1 2
U2 18
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD JUN
PY 2018
VL 183
IS 2
BP 192
EP 199
DI 10.1007/s12011-017-1128-6
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA GF1JC
UT WOS:000431689100002
PM 28856601
DA 2025-06-11
ER

PT J
AU Gobal, F
   Deshmukh, A
   Shah, S
   Mehta, JL
AF Gobal, Freij
   Deshmukh, Abhishek
   Shah, Sudhir
   Mehta, Jawahar L.
TI Triad of Metabolic Syndrome, Chronic Kidney Disease, and Coronary Heart
   Disease With a Focus on Microalbuminuria
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Review
DE chronic kidney disease; coronary heart disease; metabolic syndrome;
   microalbuminuria
ID LOW-DENSITY-LIPOPROTEIN; FOCAL SEGMENTAL GLOMERULOSCLEROSIS;
   INSULIN-RESISTANCE SYNDROME; URINARY ALBUMIN EXCRETION; ARTERY
   ENDOTHELIAL-CELLS; RENIN-ANGIOTENSIN SYSTEM; CARDIOVASCULAR EVENTS;
   RENAL-DISEASE; LECTIN-LIKE; BLOOD-PRESSURE
AB Coronary heart disease remains a major cause of morbidity and mortality in the United States, and its incidence is rising worldwide. Because atherosclerosis is a chronic process, and it is often associated with certain lifestyle and risk factors such as hypertension, dyslipidemia, and insulin resistance, much emphasis is being placed on lifestyle modification and control of risk factors. It is being recognized that some lifestyle patterns such as overeating result in metabolic syndrome, which may play a role in the development of chronic kidney disease and coronary heart disease. Here, we focus on an important relationship between these 3 conditions, and we provide evidence that microalbuminuria develops in many patients with metabolic syndrome, may be an important correlate of chronic kidney disease and coronary heart disease, and may represent an important prognostic marker. Although the pathogenesis of microalbuminuria in metabolic syndrome is not clear, we suggest that microalbuminuria, chronic kidney disease, and coronary heart disease share common pathways involving inflammation and oxidative stress. We also discuss that a healthy lifestyle is essential for preventing and treating chronic kidney disease and coronary heart disease seen in patients with metabolic syndrome. (J Am Coll Cardiol 2011;57:2303-8) (C) 2011 by the American College of Cardiology Foundation
C1 [Gobal, Freij; Deshmukh, Abhishek; Mehta, Jawahar L.] Univ Arkansas Med Sci, Div Cardiovasc, Little Rock, AR 72212 USA.
   [Gobal, Freij; Deshmukh, Abhishek; Shah, Sudhir; Mehta, Jawahar L.] Vet Affairs Med Ctr, Little Rock, AR USA.
   [Shah, Sudhir] Univ Arkansas Med Sci, Div Nephrol, Little Rock, AR 72212 USA.
C3 University of Arkansas System; University of Arkansas Medical Sciences;
   US Department of Veterans Affairs; Veterans Health Administration (VHA);
   University of Arkansas System; University of Arkansas Medical Sciences
RP Mehta, JL (corresponding author), Univ Arkansas Med Sci, Div Cardiovasc, 4301 W Markham St,Mail Slot 532, Little Rock, AR 72212 USA.
EM MehtaJL@UAMS.edu
RI Mehta, jl/AAB-8832-2019
CR ABRASS CK, 1995, J AM SOC NEPHROL, V5, P1591
   Adelman RD, 2001, J PEDIATR-US, V138, P481, DOI 10.1067/mpd.2001.113006
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   AMBROSIO G, 1994, AM J PHYSIOL, V267, pH308, DOI 10.1152/ajpheart.1994.267.1.H308
   Anilkumar N, 2008, ARTERIOSCL THROM VAS, V28, P1347, DOI 10.1161/ATVBAHA.108.164277
   [Anonymous], KIDNEY INT
   Asselbergs FW, 2004, CIRCULATION, V110, P2809, DOI 10.1161/01.CIR.0000146378.65439.7A
   Ban CR, 2008, VASC HEALTH RISK MAN, V4, P575
   Borch-Johnsen K, 1999, ARTERIOSCL THROM VAS, V19, P1992, DOI 10.1161/01.ATV.19.8.1992
   Byfield FJ, 2006, J LIPID RES, V47, P715, DOI 10.1194/jlr.M500439-JLR200
   Chagnac A, 2000, AM J PHYSIOL-RENAL, V278, pF817, DOI 10.1152/ajprenal.2000.278.5.F817
   Chen J, 2003, J AM SOC NEPHROL, V14, P469, DOI 10.1097/01.ASN.0000046029.53933.09
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Chen JW, 2006, CURR HYPERTENS REP, V8, P139, DOI 10.1007/s11906-006-0010-2
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cominacini L, 2003, J AM COLL CARDIOL, V41, P499, DOI 10.1016/S0735-1097(02)02811-5
   DZAU VJ, 1988, CIRCULATION, V77, P947, DOI 10.1161/01.CIR.77.5.947
   Festa A, 2000, KIDNEY INT, V58, P1703, DOI 10.1046/j.1523-1755.2000.00331.x
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Fried LF, 2001, KIDNEY INT, V59, P260, DOI 10.1046/j.1523-1755.2001.00487.x
   Gaede P, 2003, NEW ENGL J MED, V348, P383, DOI 10.1056/NEJMoa021778
   Gerstein HC, 2001, JAMA-J AM MED ASSOC, V286, P421, DOI 10.1001/jama.286.4.421
   Gerstein HC, 2000, LANCET, V355, P253
   GORGELS WJMJ, 1995, AM J EPIDEMIOL, V142, P1157, DOI 10.1093/oxfordjournals.aje.a117574
   Hall JE, 2004, ADV RENAL REPLACE TH, V11, P41, DOI 10.1053/j.arrt.2003.10.007
   Henegar JR, 2001, J AM SOC NEPHROL, V12, P1211, DOI 10.1681/ASN.V1261211
   Hodge AM, 1996, DIABETIC MED, V13, P441
   Holvoet P, 2001, ARTERIOSCL THROM VAS, V21, P844, DOI 10.1161/01.ATV.21.5.844
   Hu CP, 2008, HYPERTENSION, V52, P556, DOI 10.1161/HYPERTENSIONAHA.108.115287
   Hu CP, 2009, KIDNEY INT, V76, P521, DOI 10.1038/ki.2009.234
   Hunsicker LG, 1997, KIDNEY INT, V51, P1908, DOI 10.1038/ki.1997.260
   Ibsen H, 2004, J HYPERTENS, V22, P1805, DOI 10.1097/00004872-200409000-00026
   Ibsen H, 2005, HYPERTENSION, V45, P198, DOI 10.1161/01.HYP.0000154082.72286.2a
   Iseki K, 2004, KIDNEY INT, V65, P1870, DOI 10.1111/j.1523-1755.2004.00582.x
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Isomaa B, 2001, DIABETOLOGIA, V44, P1148, DOI 10.1007/s001250100615
   Jarrett R J, 1984, Diabet Med, V1, P17
   JENSEN JS, 1995, ARTERIOSCL THROM VAS, V15, P1324, DOI 10.1161/01.ATV.15.9.1324
   JIANG XZ, 1994, AM J HYPERTENS, V7, P794, DOI 10.1093/ajh/7.9.794
   Kambham N, 2001, KIDNEY INT, V59, P1498, DOI 10.1046/j.1523-1755.2001.0590041498.x
   Kamijo A, 2002, KIDNEY INT, V62, P1628, DOI 10.1046/j.1523-1755.2002.00618.x
   Karkar AM, 2001, NEPHROL DIAL TRANSPL, V16, P518, DOI 10.1093/ndt/16.3.518
   Knowler William C, 2002, N Engl J Med, V346, P393, DOI 10.1056/NEJMoa012512
   Kurella M, 2005, J AM SOC NEPHROL, V16, P2134, DOI 10.1681/ASN.2005010106
   KUUSISTO J, 1995, CIRCULATION, V91, P831, DOI 10.1161/01.CIR.91.3.831
   LAWSON DL, 1990, J LAB CLIN MED, V115, P541
   Li DY, 2000, CIRCULATION, V102, P1970, DOI 10.1161/01.CIR.102.16.1970
   Li DY, 1999, CIRC RES, V84, P1043, DOI 10.1161/01.RES.84.9.1043
   Lindström J, 2003, DIABETES CARE, V26, P3230, DOI 10.2337/diacare.26.12.3230
   MAGGI E, 1994, KIDNEY INT, V45, P876, DOI 10.1038/ki.1994.115
   MANTTARI M, 1995, HYPERTENSION, V26, P670, DOI 10.1161/01.HYP.26.4.670
   McGarry JD, 2002, DIABETES, V51, P7, DOI 10.2337/diabetes.51.1.7
   Mehta JL, 2006, J AM COLL CARDIOL, V48, P980, DOI 10.1016/j.jacc.2006.06.001
   Mehta JL, 2006, CARDIOVASC RES, V69, P36, DOI 10.1016/j.cardiores.2005.09.006
   Mehta PK, 2007, AM J PHYSIOL-CELL PH, V292, pC82, DOI 10.1152/ajpcell.00287.2006
   Meigs JB, 2001, DIABETES CARE, V24, P1403, DOI 10.2337/diacare.24.8.1403
   Milan G, 2002, OBES RES, V10, P1095, DOI 10.1038/oby.2002.149
   Mogensen CE, 2004, ANN INTERN MED, V140, P933, DOI 10.7326/0003-4819-140-11-200406010-00024
   Muntner P, 2000, KIDNEY INT, V58, P293, DOI 10.1046/j.1523-1755.2000.00165.x
   Munzel T, 1997, HERZ, V22, P158, DOI 10.1007/bf03044353
   Mykkänen L, 1998, DIABETES, V47, P793, DOI 10.2337/diabetes.47.5.793
   Nannipieri M, 1997, DIABETES CARE, V20, P1019, DOI 10.2337/diacare.20.6.1019
   Navarro JF, 1999, DIABETES CARE, V22, P1006, DOI 10.2337/diacare.22.6.1006
   Palaniappan L, 2003, AM J HYPERTENS, V16, P952, DOI 10.1016/S0895-7061(03)01009-4
   PERNEGER TV, 1993, JAMA-J AM MED ASSOC, V269, P488, DOI 10.1001/jama.269.4.488
   Praga M, 2001, NEPHROL DIAL TRANSPL, V16, P1790, DOI 10.1093/ndt/16.9.1790
   Praga M, 2002, NEPHROL DIAL TRANSPL, V17, P1157, DOI 10.1093/ndt/17.7.1157
   Sharma AM, 2004, HYPERTENSION, V44, P12, DOI 10.1161/01.HYP.0000132568.71409.a2
   Shinozaki K, 2004, HYPERTENSION, V43, P255, DOI 10.1161/01.HYP.0000111136.86976.26
   Sidell RJ, 2002, DIABETES, V51, P1110, DOI 10.2337/diabetes.51.4.1110
   Srinivasan SR, 2000, AM J HYPERTENS, V13, P1274, DOI 10.1016/S0895-7061(00)01220-6
   STEHOUWER CDA, 1992, LANCET, V340, P319, DOI 10.1016/0140-6736(92)91401-S
   Sukhija R, 2008, AM J CARDIOL, V101, P975, DOI 10.1016/j.amjcard.2007.11.042
   Sukhija R, 2006, AM J CARDIOL, V98, P279, DOI 10.1016/j.amjcard.2006.01.098
   Thomsen TF, 2001, J CARDIOVASC RISK, V8, P291, DOI 10.1097/00043798-200110000-00008
   VERANI RR, 1992, AM J KIDNEY DIS, V20, P629, DOI 10.1016/S0272-6386(12)70230-5
   WEISINGE.JR, 1974, ANN INTERN MED, V81, P440, DOI 10.7326/0003-4819-81-4-440
   Wilson PWF, 1998, CIRCULATION, V97, P1837, DOI 10.1161/01.CIR.97.18.1837
   Yudkin JS, 1999, DIABETIC MED, V16, P219, DOI 10.1046/j.1464-5491.1999.00026.x
   Yusuf S, 2000, NEW ENGL J MED, V342, P145
   Yuyun MF, 2004, AM J EPIDEMIOL, V159, P284, DOI 10.1093/aje/kwh037
NR 81
TC 36
Z9 39
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD JUN 7
PY 2011
VL 57
IS 23
BP 2303
EP 2308
DI 10.1016/j.jacc.2011.02.027
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 771HG
UT WOS:000291147200002
PM 21636030
OA Bronze
DA 2025-06-11
ER

PT J
AU Suárez-Ortegón, MF
   Arbeláez, A
   Moreno-Navarrete, JM
   Ortega-Avila, JG
   Mosquera, M
   Fernández-Real, JM
AF Suarez-Ortegon, Milton Fabian
   Arbelaez, Alejandra
   Moreno-Navarrete, Jose Maria
   Ortega-Avila, Jose Guillermo
   Mosquera, Mildrey
   Fernandez-Real, Jose Manuel
TI Soluble Transferrin Receptor, Antioxidant Status and Cardiometabolic
   Risk in Apparently Healthy Individuals
SO ANTIOXIDANTS
LA English
DT Article
DE transferrin receptor; cardiometabolic risk; antioxidant status; iron
ID BODY IRON STORES; OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; SERUM FERRITIN; GLUCOSE; PLASMA; HEPCIDIN; ASSOCIATION;
   CAPACITY
AB Body iron excess appears to be related to insulin resistance and cardiometabolic risk and increased oxidative stress might be involved in this relationship. Very few studies have described the association between soluble transferrin receptor (sTfR) levels and cardiometabolic risk in the general population or antioxidant status. There were 239 subjects (20-65 years old) included in this cross-sectional study. Linear regressions adjusting for BMI, menopausal status, insulin resistance (HOMA-IR), physical inactivity, alcohol intake and subclinical/chronic inflammation were used to describe the association between sTfR, total antioxidant capacity (TAC), and measures of cardio-metabolic risk. sTfR levels were positively associated with TAC in men (beta eta [95% confidence interval ]: 0.31 [0.14 to 0.48]) and women (beta eta = 0.24 [0.07 to 0.40]) in non-adjusted and adjusted models (p < 0.05). In men, sTfR levels were inversely associated with waist circumference (beta eta [95% confidence interval]: -1.12 [-2.30 to -0.22]) and fasting glucose (-2.7 (-4.82 to -0.57), and positively with LDL cholesterol (12.41 (6.08 to 18.57) before and after adjustments for confounding variables. LDL cholesterol had a significant and positive association with TAC in non-adjusted and adjusted models in men (p < 0.05). sTfR levels are significantly associated with antioxidant status and a few specific cardio-metabolic risk variables, independently of covariates that included serum ferritin and hepcidin. This might imply that iron biomarkers in regard to cardiometabolic risk reflect physiological contexts other than iron metabolism.
C1 [Suarez-Ortegon, Milton Fabian] Pontificia Univ Javeriana Secc Cali, Fac Ciencias Salud, Dept Alimentac & Nutr, Cali 760030, Colombia.
   [Suarez-Ortegon, Milton Fabian; Arbelaez, Alejandra; Ortega-Avila, Jose Guillermo; Mosquera, Mildrey] Univ Valle, Nutr Grp, Cali 760030, Colombia.
   [Arbelaez, Alejandra; Mosquera, Mildrey] Univ Valle, Physiol Sci Dept, Cali 760030, Colombia.
   [Moreno-Navarrete, Jose Maria; Fernandez-Real, Jose Manuel] Inst Invest Biomed Girona IdIBGi, Dept Diabet Endocrinol & Nutr, Madrid 28029, Spain.
   [Ortega-Avila, Jose Guillermo] Pontificia Univ Javeriana Secc Cali, Fac Ciencias Salud, Dept Ciencias Bas, Cali 760030, Colombia.
   [Fernandez-Real, Jose Manuel] Inst Salud Carlos III ISCIII, CIBEROBN CB06 03 010, Madrid 28029, Spain.
C3 Pontificia Universidad Javeriana; Universidad del Valle; Universidad del
   Valle; Universitat de Girona; Girona University Hospital Dr. Josep
   Trueta; Institut d'Investigacio Biomedica de Girona (IDIBGI); Pontificia
   Universidad Javeriana; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEROBN
RP Suárez-Ortegón, MF (corresponding author), Pontificia Univ Javeriana Secc Cali, Fac Ciencias Salud, Dept Alimentac & Nutr, Cali 760030, Colombia.; Suárez-Ortegón, MF (corresponding author), Univ Valle, Nutr Grp, Cali 760030, Colombia.; Fernández-Real, JM (corresponding author), Inst Invest Biomed Girona IdIBGi, Dept Diabet Endocrinol & Nutr, Madrid 28029, Spain.; Fernández-Real, JM (corresponding author), Inst Salud Carlos III ISCIII, CIBEROBN CB06 03 010, Madrid 28029, Spain.
EM milton.suarez@javerianacali.edu.co
RI Ortega, Jose Guillermo/AFR-0400-2022; Fernández-Real, Jose
   Manuel/AGH-3599-2022; Moreno-Navarrete, Jose Maria/H-9772-2015;
   Mosquera, Mildrey/AGK-3087-2022
OI ORTEGA AVILA, JOSE GUILLERMO/0000-0003-2112-3870; Suarez Ortegon, Milton
   Fabian/0000-0002-0513-5196; Moreno-Navarrete, Jose
   Maria/0000-0002-2883-511X; Mosquera, Mildrey/0000-0003-0783-5839;
   Fernandez-Real, Jose Manuel/0000-0002-7442-9323
FU Colombian Administrative Department for Development and Science
   Technology (COLCIENCIAS) [1106-45921521]; CIBERobn through FEDER Funds;
   Institut d'Investigacio Biomedica de Girona (IdIBGi)
FX This work was funded by a grant from the Colombian Administrative
   Department for Development and Science Technology (COLCIENCIAS) (grant
   1106-45921521), the Institut d'Investigacio Biomedica de Girona
   (IdIBGi), and the CIBERobn through FEDER Funds.
CR Chern JPS, 2001, DIABETES CARE, V24, P850, DOI 10.2337/diacare.24.5.850
   Simao ANC, 2008, NUTRITION, V24, P675, DOI 10.1016/j.nut.2008.03.021
   De Domenico I, 2009, P NATL ACAD SCI USA, V106, P1683, DOI 10.1073/pnas.0813318106
   Suárez-Ortegón MF, 2016, BRIT J NUTR, V116, P1165, DOI 10.1017/S0007114516002968
   Suárez-Ortegón MF, 2015, ARCH MED RES, V46, P507, DOI 10.1016/j.arcmed.2015.07.007
   Suárez-Ortegón MF, 2012, BIOL TRACE ELEM RES, V145, P283, DOI 10.1007/s12011-011-9192-9
   Fernández-Real JM, 2002, DIABETES, V51, P2348, DOI 10.2337/diabetes.51.8.2348
   Fernández-Real JM, 2007, DIABETES CARE, V30, P616, DOI 10.2337/dc06-1581
   Freixenet N, 2009, CLIN CHIM ACTA, V400, P111, DOI 10.1016/j.cca.2008.10.019
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Ganz T, 2006, AM J PHYSIOL-GASTR L, V290, pG199, DOI 10.1152/ajpgi.00412.2005
   Gao X, 2019, EUR J EPIDEMIOL, V34, P451, DOI 10.1007/s10654-019-00493-7
   Greig FH, 2012, FREE RADICAL BIO MED, V52, P266, DOI 10.1016/j.freeradbiomed.2011.10.481
   Gugliucci A, 2014, REDOX REP, V19, P154, DOI 10.1179/1351000214Y.0000000084
   Kang M, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-15674-w
   Kwak Ho-Kyung, 2007, Nutr Res Pract, V1, P335, DOI 10.4162/nrp.2007.1.4.335
   Lee BK, 2011, METABOLISM, V60, P1416, DOI 10.1016/j.metabol.2011.02.008
   Malorni W, 1998, EXP CELL RES, V241, P102, DOI 10.1006/excr.1998.4020
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Millonig G, 2012, J BIOL CHEM, V287, P37472, DOI 10.1074/jbc.M112.358911
   Moczulski DK, 2001, DIABETES CARE, V24, P1187, DOI 10.2337/diacare.24.7.1187
   Montonen J, 2012, DIABETOLOGIA, V55, P2613, DOI 10.1007/s00125-012-2633-y
   Niki E, 2012, ANN NUTR METAB, V61, P207, DOI 10.1159/000343106
   Nuhu F, 2018, PHARMACEUTICALS-BASE, V11, DOI 10.3390/ph11040103
   Orban E, 2014, DIABETES-METAB RES, V30, P372, DOI 10.1002/dmrr.2506
   Orino K, 2001, BIOCHEM J, V357, P241, DOI 10.1042/0264-6021:3570241
   Savu O, 2012, J INT MED RES, V40, P709, DOI 10.1177/147323001204000235
   Sharma R, 2020, J EVOL MED DENT SCI-, V9, P3739, DOI 10.14260/jemds/2020/821
   Souto JC, 2003, HAEMATOLOGICA, V88, P1436
   Spasojevic-Kalimanovska V, 2014, CLIN BIOCHEM, V47, P564, DOI 10.1016/j.clinbiochem.2014.03.014
   Suárez-Ortegón MF, 2022, CARDIOVASC DIABETOL, V21, DOI 10.1186/s12933-022-01450-7
   Tanaka Y, 2012, J GASTROEN HEPATOL, V27, P1711, DOI 10.1111/j.1440-1746.2012.07180.x
   TANNER LI, 1989, J CELL BIOL, V108, P1537, DOI 10.1083/jcb.108.4.1537
   van Raaij SEG, 2018, TOXICOL LETT, V295, P179, DOI 10.1016/j.toxlet.2018.06.1218
   Verhoef H, 2001, AM J CLIN NUTR, V74, P767
   Zhu SY, 2022, FRONT CELL DEV BIOL, V10, DOI 10.3389/fcell.2022.874846
NR 36
TC 2
Z9 2
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JAN
PY 2023
VL 12
IS 1
AR 19
DI 10.3390/antiox12010019
PG 10
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 8B4CF
UT WOS:000916871700001
PM 36670881
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Stanková, B
   Macásek, J
   Zeman, M
   Vecka, M
   Tvrzická, E
   Jáchymová, M
   Slaby, A
   Zák, A
AF Stankova, B.
   Macasek, J.
   Zeman, M.
   Vecka, M.
   Tvrzicka, E.
   Jachymova, M.
   Slaby, A.
   Zak, A.
TI Polymorphisms rs2167444 and rs508384 in the SCD1 Gene Are Linked
   with High ApoB-48 Levels and Adverse Profile of Cardiometabolic Risk
   Factors
SO FOLIA BIOLOGICA
LA English
DT Article
DE apolipoprotein B-48; cardiometabolic risk factors; metabolic syndrome
   components; small-dense LDL; oxidative stress; fatty acid desaturases;
   SCD1 polymorphisms
ID STEAROYL-COA DESATURASE; FATTY-ACID-COMPOSITION; APOLIPOPROTEIN B-48
   CONCENTRATION; PERIPHERAL ARTERIAL-DISEASE; REMNANT LIPOPROTEINS;
   METABOLIC SYNDROME; OXIDATIVE MODIFICATION; INSULIN-RESISTANCE; B48
   LEVEL; OBESITY
AB Elevated plasma concentration of apolipoprotein B-48 (apoB-48) is an independent risk factor of cardiovascular disease. Stearoyl-CoA desaturase-1 (SCD1) is a rate-limiting lipogenic enzyme and a key regulator of fuel metabolism. The aim of this study was to analyse associations between clinical, biochemical, and genetic factors and different apoB-48 levels in subjects at increased cardiometabolic risk. We examined 220 subjects exhibiting at least one metabolic syndrome (MetS) component. In conjunction with basic clinical, anthropometric and laboratory measurements, we analysed various polymorphisms of stearoyl-CoA desaturase-1 (SCD1). Subjects were divided into two groups according to the median apoB-48 level: (1) high apoB-48 (>= 7.9 mg/l, N = 112) and (2) low apoB-48 (< 7.9 mg/l, N = 108). Neither group differed significantly in anthropometric measures. High plasma apoB-48 levels were associated with increased systolic blood pressure (+3 %; P < 0.05), MetS prevalence (59.8 vs. 32.4 %; P < 0.001), small-dense LDL frequency (46.4 vs. 20.4 %; P < 0.001), triglycerides (+97 %; P < 0.001), non-HDL-cholesterol (+27 %; P < 0.001), and lower concentrations of HDL-cholesterol (-11 %; P < 0.01). This group was further characterized by a higher HOMA-IR index (+54 %; P < 0.001) and increased concentrations of conjugated dienes (+11 %; P < 0.001) and oxidatively modified LDL (+ 38 %; P < 0.05). Lower frequencies of SCD1 minor genotypes (rs2167444, rs508384, P < 0.05) were observed in subjects with elevated plasma concentrations of apoB-48. Elevated plasma concentrations of apoB-48 are associated with an adverse lipid profile, higher systolic blood pressure, insulin resistance, and oxidative stress. Lower proportions of minor SCD1 genotypes (rs2167444, rs508384) implicate the role of genetic factors in the pathogenesis of elevated levels of apoB-48.
C1 [Stankova, B.; Macasek, J.; Zeman, M.; Vecka, M.; Tvrzicka, E.; Slaby, A.; Zak, A.] Charles Univ Prague, Fac Med 1, Dept Med 4, Nemocnice 2, Prague 12808, Czech Republic.
   [Jachymova, M.] Charles Univ Prague, Fac Med 1, Inst Clin Chem & Lab Diagnost, Prague, Czech Republic.
   [Jachymova, M.] Gen Univ Hosp, Nemocnice 2, Prague 12808, Czech Republic.
C3 Charles University Prague; Charles University Prague; General University
   Hospital Prague
RP Zák, A (corresponding author), Charles Univ Prague, Fac Med 1, Dept Med 4, Nemocnice 2, Prague 12808, Czech Republic.; Zák, A (corresponding author), Gen Univ Hosp, Nemocnice 2, Prague 12808, Czech Republic.
EM zak.ales@email.cz
RI Slaby, Adolf/P-5060-2016; Vecka, Marek/AAB-9358-2022; Stankova,
   Barbora/L-7933-2016; Macasek, Jaroslav/G-8337-2016; Vecka,
   Marek/A-3560-2008; Zak, Ales/G-8318-2016; Zeman, Miroslav/J-5281-2016
OI Stankova, Barbora/0000-0002-6184-4878; Macasek,
   Jaroslav/0000-0002-8009-8970; Vecka, Marek/0000-0002-3269-1817; Zak,
   Ales/0000-0002-1698-6068; Zeman, Miroslav/0000-0001-5338-603X
FU Ministry of Education, Youth and Sports of the Czech Republic (Charles
   University, First Faculty of Medicine) [PROGRES Q25/LF1/2]; Ministry of
   Health of the Czech Republic [RVO-VFN64165/2012]
FX Financial support from the Ministry of Health of the Czech Republic
   (research project RVO-VFN64165/2012) and the Ministry of Education,
   Youth and Sports of the Czech Republic (research project PROGRES
   Q25/LF1/2 - Charles University, First Faculty of Medicine) is gratefully
   acknowledged.
CR Ahotupa M, 1996, CLIN BIOCHEM, V29, P139, DOI 10.1016/0009-9120(95)02043-8
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alipour A, 2012, EUR J CLIN INVEST, V42, P702, DOI 10.1111/j.1365-2362.2011.02635.x
   ALjohani AM, 2017, TRENDS ENDOCRIN MET, V28, P831, DOI 10.1016/j.tem.2017.10.003
   Arregui M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048338
   Assies J, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010635
   Byberg L, 2014, AM J CLIN NUTR, V99, P551, DOI 10.3945/ajcn.113.065714
   Chan DC, 2012, ATHEROSCLEROSIS, V221, P484, DOI 10.1016/j.atherosclerosis.2012.01.029
   Das U.N., 2010, Metabolic syndrome pathophysiology: the role of essential fatty acids
   Diffenderfer MR, 2014, CURR OPIN LIPIDOL, V25, P221, DOI 10.1097/MOL.0000000000000067
   DURNIN JVGA, 1974, BRIT J NUTR, V32, P77, DOI 10.1079/BJN19740060
   ESTERBAUER H, 1992, FREE RADICAL BIO MED, V13, P341, DOI 10.1016/0891-5849(92)90181-F
   Fazio S, 2015, CLIN LIPIDOLOGY COMP, P11
   Gazi IF, 2006, LIPIDS, V41, P647, DOI 10.1007/s11745-006-5015-8
   Gong J, 2011, J NUTR, V141, P2211, DOI 10.3945/jn.111.143503
   Hayashi T, 2008, ATHEROSCLEROSIS, V197, P154, DOI 10.1016/j.atherosclerosis.2007.03.015
   Jáchymová M, 2001, BIOCHEM BIOPH RES CO, V284, P426, DOI 10.1006/bbrc.2001.5007
   Jacobs S, 2015, EUR J CLIN NUTR, V69, P642, DOI 10.1038/ejcn.2015.36
   Kamal S, 2018, INT J BIOL MACROMOL, V114, P692, DOI 10.1016/j.ijbiomac.2018.03.171
   Kawashima A, 2009, J NUTR SCI VITAMINOL, V55, P400, DOI 10.3177/jnsv.55.400
   Kinoshita M, 2009, J ATHEROSCLER THROMB, V16, P517, DOI 10.5551/jat.No604
   Koeberle A, 2016, BBA-MOL CELL BIOL L, V1861, P1719, DOI 10.1016/j.bbalip.2016.08.009
   Kröger J, 2012, CURR OPIN LIPIDOL, V23, P4, DOI 10.1097/MOL.0b013e32834d2dc5
   Lapice E, 2012, ATHEROSCLEROSIS, V223, P504, DOI 10.1016/j.atherosclerosis.2012.05.038
   Liew CF, 2004, DIABETOLOGIA, V47, P2168, DOI 10.1007/s00125-004-1575-4
   Lohman TG, 1988, Anthropometric Standardization Reference Manual. Abridged Edition
   Mahendran Y, 2014, AM J CLIN NUTR, V99, P79, DOI 10.3945/ajcn.113.069740
   Mancera-Romero J, 2013, ACTA DIABETOL, V50, P383, DOI 10.1007/s00592-012-0434-x
   Martín-Núñez GM, 2013, MOL NUTR FOOD RES, V57, P2177, DOI 10.1002/mnfr.201300208
   Masuda D, 2017, J ATHEROSCLER THROMB, V24, P95, DOI 10.5551/jat.RV16003
   Masuda D, 2014, J ATHEROSCLER THROMB, V21, P618
   Masuda D, 2012, EUR J CLIN INVEST, V42, P992, DOI 10.1111/j.1365-2362.2012.02687.x
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mauvoisin D, 2011, BIOCHIMIE, V93, P78, DOI 10.1016/j.biochi.2010.08.001
   Merino DM, 2011, MOL GENET METAB, V103, P171, DOI 10.1016/j.ymgme.2011.02.012
   Merino DM, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-63
   MILLER SA, 1988, NUCLEIC ACIDS RES, V16, P1215, DOI 10.1093/nar/16.3.1215
   Mori K, 2013, CLIN CHIM ACTA, V421, P51, DOI 10.1016/j.cca.2013.02.005
   Nakajima K, 2006, CLIN CHIM ACTA, V367, P36, DOI 10.1016/j.cca.2005.12.013
   Nakajima K, 2018, CLIN CHIM ACTA, V478, P200, DOI 10.1016/j.cca.2017.12.039
   Ng DS, 2013, CAN J DIABETES, V37, P319, DOI 10.1016/j.jcjd.2013.07.062
   Okubo M, 2014, J ATHEROSCLER THROMB, V21, P974, DOI 10.5551/jat.23309
   Otokozawa S, 2009, METABOLISM, V58, P1536, DOI 10.1016/j.metabol.2009.04.040
   Paton CM, 2009, AM J PHYSIOL-ENDOC M, V297, pE28, DOI 10.1152/ajpendo.90897.2008
   Poloni Soraia, 2015, Biology-Basel, V4, P383, DOI 10.3390/biology4020383
   Rudkowska I, 2014, MOL NUTR FOOD RES, V58, P1079, DOI 10.1002/mnfr.201300426
   Saito E, 2013, PROSTAG LEUKOTR ESS, V88, P307, DOI 10.1016/j.plefa.2013.01.005
   Sakai N, 2003, J LIPID RES, V44, P1256, DOI 10.1194/jlr.M300090-JLR200
   SANGER F, 1975, J MOL BIOL, V94, P441, DOI 10.1016/0022-2836(75)90213-2
   SANGER F, 1977, P NATL ACAD SCI USA, V74, P5463, DOI 10.1073/pnas.74.12.5463
   Saponaro C, 2015, NUTRIENTS, V7, P9453, DOI 10.3390/nu7115475
   Sato I, 2009, J ATHEROSCLER THROMB, V16, P12, DOI 10.5551/jat.E596
   Stryjecki C, 2012, MOL GENET METAB, V105, P421, DOI 10.1016/j.ymgme.2011.12.003
   Tan CY, 2015, SCI REP-UK, V5, DOI [10.1038/srep23873, 10.1038/srep18366]
   Tanimura K, 2008, DIABETES RES CLIN PR, V81, P338, DOI 10.1016/j.diabres.2008.04.028
   Tosi F, 2014, ADV EXP MED BIOL, V824, P61, DOI 10.1007/978-3-319-07320-0_7
   Tvrzická E, 2002, ANAL CHIM ACTA, V465, P337, DOI 10.1016/S0003-2670(02)00396-3
   Uto Y, 2016, CHEM PHYS LIPIDS, V197, P3, DOI 10.1016/j.chemphyslip.2015.08.018
   Valdivielso P, 2010, CLIN CHIM ACTA, V411, P433, DOI 10.1016/j.cca.2009.12.022
   Vareka T, 2012, NEUROENDOCRINOL LETT, V33, P83
   Wang Y, 2013, PEDIATR OBES, V8, P376, DOI 10.1111/j.2047-6310.2012.00116.x
   Warensjö E, 2006, NUTR METAB CARDIOVAS, V16, P128, DOI 10.1016/j.numecd.2005.06.001
   Warensjö E, 2008, NUTR METAB CARDIOVAS, V18, P683, DOI 10.1016/j.numecd.2007.11.002
   Warensjö E, 2007, OBESITY, V15, P1732, DOI 10.1038/oby.2007.206
   Zák A, 2014, PHYSIOL RES, V63, pS375, DOI 10.33549/physiolres.932868
   Zák A, 2007, TOHOKU J EXP MED, V212, P359, DOI 10.1620/tjem.212.359
   Zeman M, 2017, METAB SYNDR RELAT D, V15, P371, DOI 10.1089/met.2017.0040
NR 67
TC 4
Z9 4
U1 0
U2 1
PU CHARLES UNIV PRAGUE, FIRST FACULTY MEDICINE
PI PRAGUE 6
PA FLEMINGOVO NAM. 2, PRAGUE 6 166 37, CZECH REPUBLIC
SN 0015-5500
J9 FOLIA BIOL-PRAGUE
JI Folia Biol.-Prague
PY 2019
VL 65
IS 4
BP 159
EP 169
PG 11
WC Biochemistry & Molecular Biology; Biology; Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Oncology; Cell Biology
GA KD1HW
UT WOS:000507623700001
PM 31903889
DA 2025-06-11
ER

PT J
AU Zore, T
   Joshi, NV
   Lizneva, D
   Azziz, R
AF Zore, Temeka
   Joshi, Nikhil V.
   Lizneva, Daria
   Azziz, Ricardo
TI Polycystic Ovarian Syndrome: Long-Term Health Consequences
SO SEMINARS IN REPRODUCTIVE MEDICINE
LA English
DT Article
DE polycystic ovarian syndrome; health consequences; metabolic dysfunction;
   cardiovascular disease; type 2 diabetes mellitus; endometrial
   adenocarcinoma; breast cancer; hypertension; depression; anxiety
ID QUALITY-OF-LIFE; IMPAIRED GLUCOSE-TOLERANCE; BREAST-CANCER RISK;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; DIABETES-MELLITUS; FOLLOW-UP;
   CARDIOVASCULAR-DISEASE; INCREASED PREVALENCE; UTERINE FIBROIDS
AB Polycystic ovarian syndrome (PCOS) is the most common endocrinopathy in women and can be associated with significant adverse sequelae that can affect overall long-term health and well-being. This review provides a succinct but comprehensive overview of our current understanding concerning the known morbidities of PCOS, beginning with a review of the importance of the different phenotypes of PCOS in determining long-term morbidity, the confounding impact of obesity on health outcomes in PCOS, and the immediate short-term consequences of the disorder (including dermatologic, reproductive, and mood disturbances). The longer-term morbidities of PCOS are then reviewed including metabolic consequences (impaired glucose tolerance and type 2 diabetes mellitus, metabolic syndrome, and nonalcoholic fatty liver disease), dyslipidemia and vascular dysfunction (including hypertension and increased incidences of cerebrovascular accidents and thromboembolisms on oral contraceptives), neoplastic (primarily endometrial adenocarcinoma), and mental health disorders (including greater incidences of depressive and anxiety disturbances and psychosexual dysfunction). In conclusion, strategies for the prevention and amelioration of long-term morbidities in PCOS are presented.
C1 [Zore, Temeka; Joshi, Nikhil V.; Azziz, Ricardo] Univ Calif Los Angeles, David Geffen Sch Med, Dept Obstet & Gynecol, Los Angeles, CA 90095 USA.
   [Lizneva, Daria; Azziz, Ricardo] Augusta Univ, Med Coll Georgia, Dept Obstet & Gynecol, Augusta, GA USA.
   [Azziz, Ricardo] State Univ New York Syst Adm, Off Acad Hlth & Hosp Affairs, Albany, NY USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA; University System of Georgia; Augusta University
RP Azziz, R (corresponding author), Univ Calif Los Angeles, David Geffen Sch Med, Dept Obstet & Gynecol, Los Angeles, CA 90095 USA.; Azziz, R (corresponding author), SUNY Albany, State Univ Plaza,S-423,353 Broadway, Albany, NY 12246 USA.
EM ricardo.azziz@suny.edu
RI Lizneva, Daria/R-5572-2016; Azziz, Ricardo/N-7229-2014; Azziz,
   Ricardo/B-7730-2008
OI Azziz, Ricardo/0000-0002-3917-0483; Lizneva, Daria
   V./0000-0002-2489-2635; Lizneva, Daria/0000-0002-2901-4268
CR Abdel-Gadir A, 2009, J REPROD MED, V54, P347
   Anderson SA, 2014, INT J CARDIOL, V176, P486, DOI 10.1016/j.ijcard.2014.06.079
   [Anonymous], NIH PUBLICATION
   Apridonidze T, 2005, J CLIN ENDOCR METAB, V90, P1929, DOI 10.1210/jc.2004-1045
   Azziz R, 2005, J CLIN ENDOCR METAB, V90, P4650, DOI 10.1210/jc.2005-0628
   Azziz R, 2001, J CLIN ENDOCR METAB, V86, P1626, DOI 10.1210/jc.86.4.1626
   Azziz R, 2006, J CLIN ENDOCR METAB, V91, P4237, DOI 10.1210/jc.2006-0178
   Azziz R, 2016, NAT REV DIS PRIMERS, V2, DOI 10.1038/nrdp.2016.57
   Balen AH, 2016, HUM REPROD UPDATE, V22, P687, DOI 10.1093/humupd/dmw025
   Barry JA, 2011, HUM REPROD, V26, P2442, DOI 10.1093/humrep/der197
   Barry JA, 2014, HUM REPROD UPDATE, V20, P748, DOI 10.1093/humupd/dmu012
   Bird ST, 2013, CAN MED ASSOC J, V185, pE115, DOI 10.1503/cmaj.120677
   Bozdag G, 2016, HUM REPROD, V31, P2841, DOI 10.1093/humrep/dew218
   BRAWMANMINTZER O, 1993, AM J PSYCHIAT, V150, P1216
   Brower M, 2013, J CLIN ENDOCR METAB, V98, pE1967, DOI 10.1210/jc.2013-2815
   Cao SF, 2017, REPROD SCI, V24, P456, DOI 10.1177/1933719116657892
   CARMINA E, 1992, AM J OBSTET GYNECOL, V167, P1807, DOI 10.1016/0002-9378(92)91779-A
   Carmina E, 2003, HUM REPROD, V18, P2289, DOI 10.1093/humrep/deg440
   Carmina E, 2008, FERTIL STERIL, V89, P642, DOI 10.1016/j.fertnstert.2007.03.085
   Carmina E, 2007, J CLIN ENDOCR METAB, V92, P2500, DOI 10.1210/jc.2006-2725
   Carmina E, 2014, SCAND J CLIN LAB INV, V74, P23, DOI 10.3109/00365513.2014.936676
   Carmina E, 2012, OBSTET GYNECOL, V119, P263, DOI 10.1097/AOG.0b013e31823f7135
   Carmina E, 2009, FERTIL STERIL, V91, P1332, DOI 10.1016/j.fertnstert.2008.03.007
   Chang J, 2004, FERTIL STERIL, V81, P19, DOI 10.1016/j.fertnstert.2003.10.004
   Chazenbalk G, 2010, J CLIN ENDOCR METAB, V95, P935, DOI 10.1210/jc.2009-1158
   Chen YH, 2013, DIABETES, V62, P2278, DOI 10.2337/db12-0963
   Christian RC, 2003, J CLIN ENDOCR METAB, V88, P2562, DOI 10.1210/jc.2003-030334
   Cinar N, 2011, HUM REPROD, V26, P3339, DOI 10.1093/humrep/der338
   Col NF, 2012, BREAST CANCER RES TR, V135, P639, DOI 10.1007/s10549-012-2170-x
   Cronin L, 1998, J CLIN ENDOCR METAB, V83, P1976, DOI 10.1210/jc.83.6.1976
   DeUgarte CM, 2006, J CLIN ENDOCR METAB, V91, P1345, DOI 10.1210/jc.2004-2301
   Diamanti-Kandarakis E, 2007, CLIN ENDOCRINOL, V67, P735, DOI 10.1111/j.1365-2265.2007.02954.x
   Diamanti-Kandarakis E, 2012, ENDOCR REV, V33, P981, DOI 10.1210/er.2011-1034
   Dokras A, 2005, OBSTET GYNECOL, V106, P131, DOI 10.1097/01.AOG.0000167408.30893.6b
   Dokras A, 2012, STEROIDS, V77, P338, DOI 10.1016/j.steroids.2011.12.008
   Dokras A, 2012, FERTIL STERIL, V97, P225, DOI 10.1016/j.fertnstert.2011.10.022
   Dokras A, 2011, OBSTET GYNECOL, V117, P145, DOI 10.1097/AOG.0b013e318202b0a4
   Dumesic DA, 2016, J CLIN ENDOCR METAB, V101, P4178, DOI 10.1210/jc.2016-2586
   Dumesic DA, 2013, STEROIDS, V78, P782, DOI 10.1016/j.steroids.2013.04.004
   Dunaif A, 1996, J CLIN ENDOCR METAB, V81, P942, DOI 10.1210/jc.81.3.942
   Ehrmann DA, 2005, NEW ENGL J MED, V352, P1223, DOI 10.1056/NEJMra041536
   Ehrmann DA, 2006, J CLIN ENDOCR METAB, V91, P48, DOI 10.1210/jc.2005-1329
   Elsenbruch S, 2003, J CLIN ENDOCR METAB, V88, P5801, DOI 10.1210/jc.2003-030562
   Elting MW, 2001, HUM REPROD, V16, P556, DOI 10.1093/humrep/16.3.556
   Escobar-Morreale HF, 2012, HUM REPROD UPDATE, V18, P146, DOI 10.1093/humupd/dmr042
   Ezeh U, 2013, J CLIN ENDOCR METAB, V98, P1541, DOI 10.1210/jc.2012-2937
   Fauser BCJM, 2012, FERTIL STERIL, V97, P28, DOI 10.1016/j.fertnstert.2011.09.024
   Fauser BCJM, 2004, HUM REPROD, V19, P41, DOI 10.1093/humrep/deh098
   Gao L, 2012, EXP CLIN ENDOCR DIAB, V120, P367, DOI 10.1055/s-0032-1304619
   Gottschau M, 2015, GYNECOL ONCOL, V136, P99, DOI 10.1016/j.ygyno.2014.11.012
   Guo Y, 2016, PLASMONICS, V11, P11, DOI [10.1371/journal.pone.0156323, 10.1007/s11468-015-0008-1]
   Guyatt G, 2004, J CLIN EPIDEMIOL, V57, P1279, DOI 10.1016/j.jclinepi.2003.10.018
   Haoula Z, 2012, HUM REPROD, V27, P1327, DOI 10.1093/humrep/des042
   Hardiman P, 2003, LANCET, V361, P1810, DOI 10.1016/S0140-6736(03)13409-5
   Hasin DS, 2005, ARCH GEN PSYCHIAT, V62, P1097, DOI 10.1001/archpsyc.62.10.1097
   Hollinrake E, 2007, FERTIL STERIL, V87, P1369, DOI 10.1016/j.fertnstert.2006.11.039
   Hvidtfeldt UA, 2012, CANCER EPIDEM BIOMAR, V21, P1203, DOI 10.1158/1055-9965.EPI-12-0310
   Joham AE, 2014, HUM REPROD, V29, P802, DOI 10.1093/humrep/deu020
   Joham AE, 2015, J WOMENS HEALTH, V24, P299, DOI 10.1089/jwh.2014.5000
   KIDDY DS, 1992, CLIN ENDOCRINOL, V36, P105, DOI 10.1111/j.1365-2265.1992.tb02909.x
   Kim J, 2016, CANCER CAUSE CONTROL, V27, P403, DOI 10.1007/s10552-016-0716-7
   Knowler William C, 2002, N Engl J Med, V346, P393, DOI 10.1056/NEJMoa012512
   Legro RS, 2013, J CLIN ENDOCR METAB, V98, P4565, DOI 10.1210/jc.2013-2350
   Legro RS, 1999, J CLIN ENDOCR METAB, V84, P165, DOI 10.1210/jc.84.1.165
   Li YA, 2011, FERTIL STERIL, V96, P452, DOI 10.1016/j.fertnstert.2011.05.072
   Lim SS, 2012, HUM REPROD UPDATE, V18, P618, DOI 10.1093/humupd/dms030
   Lizneva D, 2016, FERTIL STERIL, V106, P1510, DOI 10.1016/j.fertnstert.2016.07.1121
   Lizneva D, 2016, FERTIL STERIL, V106, P6, DOI 10.1016/j.fertnstert.2016.05.003
   Luque-Ramírez M, 2015, EUR J ENDOCRINOL, V173, P603, DOI 10.1530/EJE-15-0646
   Månsson M, 2011, EUR J OBSTET GYN R B, V155, P161, DOI 10.1016/j.ejogrb.2010.12.012
   Merz CNB, 2016, J WOMENS HEALTH, V25, P875, DOI 10.1089/jwh.2015.5441
   Morales AJ, 1996, J CLIN ENDOCR METAB, V81, P2854, DOI 10.1210/jc.81.8.2854
   Moran LJ, 2013, HUM REPROD UPDATE, V19, P432, DOI 10.1093/humupd/dmt015
   Moran LJ, 2010, HUM REPROD UPDATE, V16, P347, DOI 10.1093/humupd/dmq001
   Naderpoor N, 2015, HUM REPROD UPDATE, V21, P560, DOI 10.1093/humupd/dmv025
   Ogden C.L., 2015, NCHS Data Brief, P1, DOI [DOI 10.1017/S1368980017000088, 10.1017/S1368980017000088]
   Quinn M, 2014, FERTIL STERIL, V101, P1129, DOI 10.1016/j.fertnstert.2014.01.003
   Renehan AG, 2008, LANCET, V371, P569, DOI 10.1016/S0140-6736(08)60269-X
   ROMANOWSKI Mariana Drechmer, 2015, Arq. Gastroenterol., V52, P117, DOI 10.1590/S0004-28032015000200008
   Salpeter SR, 2008, AM J MED, V121, P149, DOI 10.1016/j.amjmed.2007.09.016
   Schildkraut JM, 1996, OBSTET GYNECOL, V88, P554, DOI 10.1016/0029-7844(96)00226-8
   Schmidt J, 2011, J CLIN ENDOCR METAB, V96, P3794, DOI 10.1210/jc.2011-1677
   Shobeiri Fatemeh, 2016, Obstet Gynecol Sci, V59, P367, DOI 10.5468/ogs.2016.59.5.367
   Shroff R, 2007, FERTIL STERIL, V88, P1389, DOI 10.1016/j.fertnstert.2007.01.032
   Teede H, 2010, BMC MED, V8, DOI 10.1186/1741-7015-8-41
   Valkenburg O, 2008, J CLIN ENDOCR METAB, V93, P470, DOI 10.1210/jc.2007-1756
   Vassilatou E, 2015, EUR J ENDOCRINOL, V173, P739, DOI 10.1530/EJE-15-0567
   Veltman-Verhulst SM, 2012, HUM REPROD UPDATE, V18, P638, DOI 10.1093/humupd/dms029
   Vrbíková J, 2004, J CLIN ENDOCR METAB, V89, P2942, DOI 10.1210/jc.2003-031378
   Wise LA, 2007, FERTIL STERIL, V87, P1108, DOI 10.1016/j.fertnstert.2006.11.012
   Wolf I, 2005, LANCET ONCOL, V6, P103, DOI 10.1016/S1470-2045(05)01736-5
   Wong JYY, 2016, J CLIN ENDOCR METAB, V101, P122, DOI 10.1210/jc.2015-2935
   Zawadzki J., 1992, Diagnostic criteria for polycystic ovary syndrome: towards a rational approach
   Zhao XM, 2010, INT J GYNECOL OBSTET, V108, P148, DOI 10.1016/j.ijgo.2009.09.021
NR 94
TC 41
Z9 42
U1 1
U2 25
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1526-8004
EI 1526-4564
J9 SEMIN REPROD MED
JI Semin. Reprod. Med.
PD MAY
PY 2017
VL 35
IS 3
BP 271
EP 281
DI 10.1055/s-0037-1603096
PG 11
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA EZ2HG
UT WOS:000404529800011
PM 28658711
DA 2025-06-11
ER

PT J
AU Bonora, E
AF Bonora, E
TI The metabolic syndrome and cardiovascular disease
SO ANNALS OF MEDICINE
LA English
DT Review
DE cardiovascular disease; central obesity; dyslipidaemia; hypertension;
   insulin resistance; metabolic syndrome; microalbuminuria; type 2
   diabetes mellitus
ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; INSULIN-RESISTANCE SYNDROME;
   DENSITY-LIPOPROTEIN CHOLESTEROL; SAN-ANTONIO HEART;
   PLASMINOGEN-ACTIVATOR INHIBITOR; MIDDLE-AGED MEN; CIRCULATING ADHESION
   MOLECULES; FUTURE MYOCARDIAL-INFARCTION; HOMEOSTASIS MODEL ASSESSMENT
AB The metabolic syndrome, which is very common in the general population, is defined by the clustering of several classic cardiovascular risk factors, such as type 2 diabetes, hypertension, high triglycerides and low high-density lipoprotein cholesterol (HDL). Central obesity and insulin resistance, which are the two underlying disorders of the syndrome, are further risk factors for cardiovascular disease. Moreover, a panel of novel (non-traditional) risk factors are ancillary features of the metabolic syndrome. They include biomarkers of chronic mild inflammation (e.g. C-reactive protein, CRP), increased oxidant stress (e.g. oxidized low density lipoprotein, LDL), thrombophilia (e.g. plasminogen activator inhibitor-1, PAI-1) and endothelial dysfunction (e.g. E-selectin). Therefore, subjects with the metabolic syndrome are potentially at high risk of developing atherosclerosis and clinical cardiovascular events.
   In recent years several longitudinal studies have confirmed that subjects with the metabolic syndrome present with atherosclerosis and suffer from myocardial infarction and stroke at rates higher than subjects without the syndrome. The risk of cardiovascular disease (CVD) is particularly high in women with the syndrome and in subjects with pre-existing diabetes, CVD and/or high CRP. However, an increased risk is already present in subjects with a cluster of multiple mild abnormalities. The risk related to the metabolic syndrome is definitely higher when subjects affected are compared to subjects free of any metabolic abnormality.
C1 Univ Verona, Sch Med, Dept Endocrinol & Metab Dis, I-37100 Verona, Italy.
C3 University of Verona
RP Osped Maggiore, Piazzale Stefani 1, I-37126 Verona, Italy.
EM enzo.bonora@univr.it
RI Bonora, Enzo/AAA-5300-2022
OI BONORA, Enzo/0000-0003-1074-5164
CR Ahima RS, 2000, TRENDS ENDOCRIN MET, V11, P327, DOI 10.1016/S1043-2760(00)00301-5
   Anand SS, 2003, CIRCULATION, V108, P420, DOI 10.1161/01.CIR.0000080884.27358.49
   ASSMANN G, 1992, AM J CARDIOL, V70, P733, DOI 10.1016/0002-9149(92)90550-I
   AUSTIN MA, 1988, JAMA-J AM MED ASSOC, V260, P1917
   Avogaro P., 1967, Acta Diabetologica Latina, V4, P572, DOI 10.1007/BF01544100
   Balkau B, 1999, DIABETIC MED, V16, P442
   Balkau B, 2002, DIABETES METAB, V28, P364
   Berg AH, 2005, CIRC RES, V96, P939, DOI 10.1161/01.RES.0000163635.62927.34
   BJORNTORP P, 1991, DIABETES CARE, V14, P1132, DOI 10.2337/diacare.14.12.1132
   BODARY PF, 2005, ARTERIOSCLER THROMB, V25, P1634
   Bonadonna RC, 1997, DIABETES REV, V5, P21
   Bonora E, 1996, INT J OBESITY, V20, P28
   BONORA E, 1992, AM J EPIDEMIOL, V135, P1271, DOI 10.1093/oxfordjournals.aje.a116233
   Bonora E, 1997, DIABETES CARE, V20, P627, DOI 10.2337/diacare.20.4.627
   Bonora E, 2002, DIABETES CARE, V25, P1135, DOI 10.2337/diacare.25.7.1135
   Bonora E, 2004, DIABETIC MED, V21, P52, DOI 10.1046/j.1464-5491.2003.01068.x
   Bonora E, 2003, INT J OBESITY, V27, P1283, DOI 10.1038/sj.ijo.0802381
   Bonora E, 2003, DIABETES CARE, V26, P1251, DOI 10.2337/diacare.26.4.1251
   Bonora E, 2000, DIABETES CARE, V23, P57, DOI 10.2337/diacare.23.1.57
   BONORA E, 1993, DIABETES, V42, P764, DOI 10.2337/diabetes.42.5.764
   Bonora E, 1998, DIABETES CARE, V21, P221, DOI 10.2337/diacare.21.2.221
   BONORA E, 1992, DIABETES, V41, P1151, DOI 10.2337/diabetes.41.9.1151
   Bonora E, 2002, DIABETIC MED, V19, P535, DOI 10.1046/j.1464-5491.2002.00764.x
   Bonora E, 2001, J CLIN ENDOCR METAB, V86, P2073, DOI 10.1210/jc.86.5.2073
   Bonora E, 1998, DIABETES, V47, P1643, DOI 10.2337/diabetes.47.10.1643
   Bonora E, 2000, INT J OBESITY, V24, pS32, DOI 10.1038/sj.ijo.0801274
   Bonora E, 2000, DIABETOLOGIA, V43, P156, DOI 10.1007/s001250050024
   Bonora E, 1995, METABOLISM, V44, P1617, DOI 10.1016/0026-0495(95)90084-5
   Borch-Johnsen K, 1999, ARTERIOSCL THROM VAS, V19, P1992, DOI 10.1161/01.ATV.19.8.1992
   Borch-Johnsen K, 2001, ARCH INTERN MED, V161, P397, DOI 10.1001/archinte.161.3.397
   Boyko EJ, 2000, DIABETES CARE, V23, P465, DOI 10.2337/diacare.23.4.465
   Bressler P, 1996, DIABETOLOGIA, V39, P1345, DOI 10.1007/s001250050581
   Brown DW, 2001, J CLIN EPIDEMIOL, V54, P316, DOI 10.1016/S0895-4356(00)00296-1
   Brunner H, 2005, J HYPERTENS, V23, P233, DOI 10.1097/00004872-200502000-00001
   Brunzell JD, 2003, AM J MED, V115, P24, DOI 10.1016/j.amjmed.2003.08.011
   BRUNZELL JD, 1984, ARTERIOSCLEROSIS, V4, P79, DOI 10.1161/01.ATV.4.2.79
   Byrne CD, 1999, DIABETIC MED, V16, P1007, DOI 10.1046/j.1464-5491.1999.00184.x
   Carr DB, 2004, DIABETES, V53, P2087, DOI 10.2337/diabetes.53.8.2087
   CASTELLI WP, 1986, JAMA-J AM MED ASSOC, V256, P2835, DOI 10.1001/jama.256.20.2835
   Chandran M, 2003, DIABETES CARE, V26, P2442, DOI 10.2337/diacare.26.8.2442
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   Cines DB, 1998, BLOOD, V91, P3527
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Culleton BF, 1999, ANN INTERN MED, V131, P7, DOI 10.7326/0003-4819-131-1-199907060-00003
   Danesh J, 1998, JAMA-J AM MED ASSOC, V279, P1477, DOI 10.1001/jama.279.18.1477
   de Marco R, 1999, DIABETES CARE, V22, P756, DOI 10.2337/diacare.22.5.756
   DEFRONZO RA, 1991, DIABETES CARE, V14, P173, DOI 10.2337/diacare.14.3.173
   Dekker JM, 2005, CIRCULATION, V112, P666, DOI 10.1161/CIRCULATIONAHA.104.516948
   DELPRATO S, 1993, J CLIN INVEST, V91, P484, DOI 10.1172/JCI116226
   Donahue RP, 1999, DIABETES CARE, V22, P1092, DOI 10.2337/diacare.22.7.1092
   Dunder K, 2004, AM HEART J, V148, P596, DOI 10.1016/j.ahj.2004.03.021
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Einhorn D., 2002, Endocr Pract, V9, P236
   Erikssen G, 2000, EUR HEART J, V21, P1614, DOI 10.1053/euhj.2000.2148
   Expert Committee on the Diagnosis and Classification of Diabetes Mellitus, 2003, Diabetes Care, V26, pS5, DOI 10.2337/diacare.26.2007.S5
   Falk E., 1996, Atherosclerosis and coronary artery disease, V2, P492
   Fang J, 2000, JAMA-J AM MED ASSOC, V283, P2404, DOI 10.1001/jama.283.18.2404
   Fernández-Real JM, 1998, DIABETES CARE, V21, P62, DOI 10.2337/diacare.21.1.62
   Festa A, 1999, ARTERIOSCL THROM VAS, V19, P562, DOI 10.1161/01.ATV.19.3.562
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Folsom AR, 2001, THROMB HAEMOSTASIS, V86, P366
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Fujimoto WY, 1999, DIABETES CARE, V22, P1808, DOI 10.2337/diacare.22.11.1808
   GARRISON RJ, 1980, METABOLISM, V29, P1053, DOI 10.1016/0026-0495(80)90216-4
   GEARING AJH, 1993, IMMUNOL TODAY, V14, P506, DOI 10.1016/0167-5699(93)90267-O
   Girman CJ, 2004, AM J CARDIOL, V93, P136, DOI 10.1016/j.amjcard.2003.09.028
   Gotto AM, 1998, CIRCULATION, V97, P1027, DOI 10.1161/01.CIR.97.11.1027
   Grant PJ, 2003, DIABETES METAB, V29, pS44
   Grundy SM, 1999, CIRCULATION, V100, P1134, DOI 10.1161/01.CIR.100.10.1134
   Gu K, 1998, DIABETES CARE, V21, P1138, DOI 10.2337/diacare.21.7.1138
   Haffner SM, 2002, CIRCULATION, V106, P679, DOI 10.1161/01.CIR.0000025403.20953.23
   Hak AE, 2001, J CLIN ENDOCR METAB, V86, P4398, DOI 10.1210/jc.86.9.4398
   Halcox JPJ, 2002, CIRCULATION, V106, P653, DOI 10.1161/01.CIR.0000025404.78001.D8
   Halle M, 1999, ATHEROSCLEROSIS, V143, P185, DOI 10.1016/S0021-9150(98)00278-0
   Hanley AJG, 2002, DIABETES CARE, V25, P1177, DOI 10.2337/diacare.25.7.1177
   HARRIS TB, 1993, AM J EPIDEMIOL, V137, P1318, DOI 10.1093/oxfordjournals.aje.a116641
   He J, 1999, AM HEART J, V138, pS211, DOI 10.1016/S0002-8703(99)70312-1
   Hedblad B, 2002, DIABETIC MED, V19, P470, DOI 10.1046/j.1464-5491.2002.00719.x
   HIJIERMANN I, 1992, J CARDIOVASC PHAR S8, V20, pS5
   Hokanson J E, 1996, J Cardiovasc Risk, V3, P213, DOI 10.1097/00043798-199604000-00014
   Holvoet P, 2004, DIABETES, V53, P1068, DOI 10.2337/diabetes.53.4.1068
   Howard G, 1996, CIRCULATION, V93, P1809, DOI 10.1161/01.CIR.93.10.1809
   Hu G, 2004, ARCH INTERN MED, V164, P1066, DOI 10.1001/archinte.164.10.1066
   HUBERT HB, 1983, CIRCULATION, V67, P968, DOI 10.1161/01.CIR.67.5.968
   Hunt KJ, 2004, CIRCULATION, V110, P1251, DOI 10.1161/01.CIR.0000140762.04598.F9
   Hwang SJ, 1997, CIRCULATION, V96, P4219
   *IDF CONS, IDF CONS WORLDW DEF
   Imperatore G, 1998, DIABETES CARE, V21, P649, DOI 10.2337/diacare.21.4.649
   INCHIOSTRO S, 1994, DIABETOLOGIA, V37, P597, DOI 10.1007/BF00403379
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   JACOBS DR, 1990, AM J EPIDEMIOL, V131, P32, DOI 10.1093/oxfordjournals.aje.a115483
   Jouven X, 2001, CIRCULATION, V104, P756, DOI 10.1161/hc3201.094151
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   Kanellis J, 2005, SEMIN NEPHROL, V25, P39, DOI 10.1016/j.semnephrol.2004.09.007
   KANNEL WB, 1971, AM J CARDIOL, V27, P335, DOI 10.1016/0002-9149(71)90428-0
   KANNEL WB, 1987, JAMA-J AM MED ASSOC, V258, P1183, DOI 10.1001/jama.258.9.1183
   KANNEL WB, 1979, JAMA-J AM MED ASSOC, V241, P2035, DOI 10.1001/jama.241.19.2035
   KANNEL WB, 1967, CIRCULATION, V35, P734, DOI 10.1161/01.CIR.35.4.734
   KAPLAN NM, 1989, ARCH INTERN MED, V149, P1514, DOI 10.1001/archinte.149.7.1514
   Khaw KT, 2001, BMJ-BRIT MED J, V322, P15, DOI 10.1136/bmj.322.7277.15
   Kiechl S, 2001, CIRCULATION, V103, P1064, DOI 10.1161/01.CIR.103.8.1064
   Kiechl S, 2002, NEW ENGL J MED, V347, P185, DOI 10.1056/NEJMoa012673
   Kiechl S, 1997, CIRCULATION, V96, P3300
   Klausen K, 2004, CIRCULATION, V110, P32, DOI 10.1161/01.CIR.0000133312.96477.48
   KLEINMAN JC, 1988, AM J EPIDEMIOL, V128, P389, DOI 10.1093/oxfordjournals.aje.a114979
   KNOWLER WC, 1981, AM J EPIDEMIOL, V113, P144, DOI 10.1093/oxfordjournals.aje.a113079
   Kohler HP, 2000, NEW ENGL J MED, V342, P1792, DOI 10.1056/NEJM200006153422406
   Kopp HP, 2003, ARTERIOSCL THROM VAS, V23, P1042, DOI 10.1161/01.ATV.0000073313.16135.21
   Kuller LH, 2000, ARTERIOSCL THROM VAS, V20, P823, DOI 10.1161/01.ATV.20.3.823
   Kuusisto J, 2001, DIABETES CARE, V24, P1629, DOI 10.2337/diacare.24.9.1629
   Kylin E., 1923, Zentralbl Inn Med, V44, P105
   LAAKSO M, 1991, ARTERIOSCLER THROMB, V11, P1068, DOI 10.1161/01.ATV.11.4.1068
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lamarche B, 1996, CIRCULATION, V94, P273, DOI 10.1161/01.CIR.94.3.273
   LANDIN K, 1991, J INTERN MED, V229, P181, DOI 10.1111/j.1365-2796.1991.tb00328.x
   LAPIDUS L, 1984, BMJ-BRIT MED J, V289, P1257, DOI 10.1136/bmj.289.6454.1257
   LARSSON B, 1984, BMJ-BRIT MED J, V288, P1401, DOI 10.1136/bmj.288.6428.1401
   Lemieux I, 2000, CIRCULATION, V102, P179, DOI 10.1161/01.CIR.102.2.179
   Lempiäinen P, 1999, CIRCULATION, V100, P123, DOI 10.1161/01.CIR.100.2.123
   Lewis GF, 2005, CIRC RES, V96, P1221, DOI 10.1161/01.RES.0000170946.56981.5c
   Leyva F, 1998, ARTERIOSCL THROM VAS, V18, P928, DOI 10.1161/01.ATV.18.6.928
   Libby P, 2002, CIRCULATION, V105, P1135, DOI 10.1161/hc0902.104353
   Liuzzo G, 2001, Rays, V26, P221
   Lusis AJ, 2000, NATURE, V407, P233, DOI 10.1038/35025203
   Malik I, 2001, LANCET, V358, P971, DOI 10.1016/S0140-6736(01)06104-9
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   MANSON JAE, 1990, NEW ENGL J MED, V322, P882, DOI 10.1056/NEJM199003293221303
   MANSON JE, 1991, ARCH INTERN MED, V151, P1141, DOI 10.1001/archinte.151.6.1141
   Matsuzawa Y, 2004, ARTERIOSCL THROM VAS, V24, P29, DOI 10.1161/01.ATV.0000099786.99623.EF
   McNeill AM, 2005, DIABETES CARE, V28, P385, DOI 10.2337/diacare.28.2.385
   Meigs JB, 2001, DIABETES CARE, V24, P1403, DOI 10.2337/diacare.24.8.1403
   Meigs JB, 2003, DIABETES, V52, P2160, DOI 10.2337/diabetes.52.8.2160
   Mendall MA, 1996, BRIT MED J, V312, P1061
   Miettinen H, 1998, DIABETES CARE, V21, P69, DOI 10.2337/diacare.21.1.69
   Miller M, 1998, J AM COLL CARDIOL, V31, P1252, DOI 10.1016/S0735-1097(98)00083-7
   MODAN M, 1985, J CLIN INVEST, V75, P809, DOI 10.1172/JCI111776
   MODKAD AH, 1999, JAMA-J AM MED ASSOC, V282, P1519
   MURAKAMI T, 1995, ARTERIOSCL THROM VAS, V15, P1819, DOI 10.1161/01.ATV.15.11.1819
   Nagi DK, 1996, METABOLISM, V45, P1243, DOI 10.1016/S0026-0495(96)90242-5
   NAGI DK, 1993, DIABETES CARE, V16, P621, DOI 10.2337/diacare.16.4.621
   Navab M, 2005, ANN MED, V37, P173, DOI 10.1080/07853890510007322
   Niskanen LK, 2004, ARCH INTERN MED, V164, P1546, DOI 10.1001/archinte.164.14.1546
   O'Donnell CJ, 1998, J HYPERTENS, V16, pS3
   ODEA K, 1984, DIABETES, V33, P596, DOI 10.2337/diabetes.33.6.596
   OHLSON LO, 1985, DIABETES, V34, P1055, DOI 10.2337/diabetes.34.10.1055
   OLSSON T, 1990, DIABETOLOGIA, V33, P244, DOI 10.1007/BF00404803
   Palaniappan L, 2004, DIABETES CARE, V27, P788, DOI 10.2337/diacare.27.3.788
   PANZA JA, 2000, NEW ENGL J MED, V323, P22
   Parulkar AA, 2001, ANN INTERN MED, V134, P61, DOI 10.7326/0003-4819-134-1-200101020-00014
   Pickup JC, 1997, DIABETOLOGIA, V40, P1286, DOI 10.1007/s001250050822
   Pischon T, 2004, JAMA-J AM MED ASSOC, V291, P1730, DOI 10.1001/jama.291.14.1730
   POULIOT MC, 1994, AM J CARDIOL, V73, P460, DOI 10.1016/0002-9149(94)90676-9
   Pyörälä M, 2000, ARTERIOSCL THROM VAS, V20, P538, DOI 10.1161/01.ATV.20.2.538
   Raji A, 2003, DIABETES CARE, V26, P172, DOI 10.2337/diacare.26.1.172
   Reaven G, 2001, AM J CARDIOL, V87, P827, DOI 10.1016/S0002-9149(00)01521-6
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   Ridker PM, 2000, CIRCULATION, V101, P2149, DOI 10.1161/01.CIR.101.18.2149
   Ridker PM, 2004, CIRCULATION, V109, P6, DOI 10.1161/01.CIR.0000133444.17867.56
   Ridker PM, 2000, CIRCULATION, V101, P1767, DOI 10.1161/01.CIR.101.15.1767
   Ridker PM, 1998, CIRCULATION, V98, P731, DOI 10.1161/01.CIR.98.8.731
   Ridker PM, 1998, LANCET, V351, P88, DOI 10.1016/S0140-6736(97)09032-6
   Ridker PM, 2002, NEW ENGL J MED, V347, P1557, DOI 10.1056/NEJMoa021993
   Ridker PM, 2001, CIRCULATION, V103, P491, DOI 10.1161/01.CIR.103.4.491
   Ridker PM, 2000, NEW ENGL J MED, V342, P836, DOI 10.1056/NEJM200003233421202
   Robins SJ, 2003, DIABETES CARE, V26, P1513, DOI 10.2337/diacare.26.5.1513
   Rosenblatt MA, 2000, J CLIN ANESTH, V12, P413, DOI 10.1016/S0952-8180(00)00181-1
   RUTAN GH, 1988, CIRCULATION, V77, P504, DOI 10.1161/01.CIR.77.3.504
   Rutter MK, 2004, CIRCULATION, V110, P380, DOI 10.1161/01.CIR.0000136581.59584.0E
   Saggiani F, 1996, METABOLISM, V45, P1557, DOI 10.1016/S0026-0495(96)90188-2
   Satoh N, 2003, DIABETES CARE, V26, P2493, DOI 10.2337/diacare.26.9.2493
   Sattar N, 2003, CIRCULATION, V108, P414, DOI 10.1161/01.CIR.0000080897.52664.94
   Schlotte V, 1998, FREE RADICAL BIO MED, V25, P839, DOI 10.1016/S0891-5849(98)00160-9
   Schmidt MI, 1996, METABOLISM, V45, P699, DOI 10.1016/S0026-0495(96)90134-1
   Schulze MB, 2004, DIABETES CARE, V27, P889, DOI 10.2337/diacare.27.4.889
   Scuteri A, 2005, DIABETES CARE, V28, P882, DOI 10.2337/diacare.28.4.882
   SEIDELL JC, 1987, AM J CLIN NUTR, V45, P7, DOI 10.1093/ajcn/45.1.7
   Shin HJ, 2005, BIOCHEM BIOPH RES CO, V329, P18, DOI 10.1016/j.bbrc.2004.12.195
   STAMLER J, 1993, DIABETES CARE, V16, P434, DOI 10.2337/diacare.16.2.434
   STAMLER R, 1978, JAMA-J AM MED ASSOC, V240, P1607, DOI 10.1001/jama.240.15.1607
   STAMPFER MJ, 1991, NEW ENGL J MED, V325, P373, DOI 10.1056/NEJM199108083250601
   Stehouwer CDA, 2002, DIABETES, V51, P1157, DOI 10.2337/diabetes.51.4.1157
   Steinberg HO, 2002, DIABETOLOGIA, V45, P623, DOI 10.1007/s00125-002-0800-2
   Stocker R, 2004, PHYSIOL REV, V84, P1381, DOI 10.1152/physrev.00047.2003
   Tanne D, 2001, CIRCULATION, V104, P2892, DOI 10.1161/hc4901.100384
   Targonski PV, 2003, CIRCULATION, V107, P2805, DOI 10.1161/01.CIR.0000072765.93106.EE
   Temelkova-Kurktschiev T, 2002, METABOLISM, V51, P743, DOI 10.1053/meta.2002.32804
   Thögersen AM, 1998, CIRCULATION, V98, P2241, DOI 10.1161/01.CIR.98.21.2241
   Toft I, 1997, ARTERIOSCL THROM VAS, V17, P553, DOI 10.1161/01.ATV.17.3.553
   Toshima S, 2000, ARTERIOSCL THROM VAS, V20, P2243, DOI 10.1161/01.ATV.20.10.2243
   Turner RC, 1998, LANCET, V352, P837, DOI 10.1016/s0140-6736(98)07019-6
   VAGUE J, 1947, PRESSE MED, V55, P339
   Valmadrid CT, 2000, ARCH INTERN MED, V160, P1093, DOI 10.1001/archinte.160.8.1093
   Vasan Ramachandran S., 2001, New England Journal of Medicine, V345, P1291, DOI 10.1056/NEJMoa003417
   VIBERTI G, 1988, DIABETES CARE, V11, P840, DOI 10.2337/diacare.11.10.840
   VUORINENMARKKOLA H, 1994, J CLIN ENDOCR METAB, V78, P25, DOI 10.1210/jc.78.1.25
   Wallace AM, 2001, CIRCULATION, V104, P3052, DOI 10.1161/hc5001.101061
   Wallenfeldt K, 2004, STROKE, V35, P2248, DOI 10.1161/01.STR.0000140629.65145.3c
   Wannamethee SG, 2004, DIABETOLOGIA, V47, P1557, DOI 10.1007/s00125-004-1491-7
   Wei M, 1998, DIABETES CARE, V21, P1167, DOI 10.2337/diacare.21.7.1167
   Weyer C, 2001, J CLIN ENDOCR METAB, V86, P1930, DOI 10.1210/jc.86.5.1930
   *WHO CONS, 1999, PUBL WHO
   Wild S, 2004, DIABETES CARE, V27, P1047, DOI 10.2337/diacare.27.5.1047
   WILHELMSEN L, 1984, NEW ENGL J MED, V311, P501, DOI 10.1056/NEJM198408233110804
   Willeit J, 2000, ARTERIOSCL THROM VAS, V20, P529, DOI 10.1161/01.ATV.20.2.529
   Yu JG, 2002, DIABETES, V51, P2968, DOI 10.2337/diabetes.51.10.2968
   Yudkin JS, 1999, ARTERIOSCL THROM VAS, V19, P972, DOI 10.1161/01.ATV.19.4.972
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
   ZAVARONI I, 1989, NEW ENGL J MED, V320, P702, DOI 10.1056/NEJM198903163201105
   Ziccardi P, 2002, CIRCULATION, V105, P804, DOI 10.1161/hc0702.104279
   ZIMMET PZ, 1993, DIABETES CARE, V16, P56, DOI 10.2337/diacare.16.3.56
NR 211
TC 165
Z9 185
U1 4
U2 18
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PY 2006
VL 38
IS 1
BP 64
EP 80
DI 10.1080/07853890500401234
PG 17
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 013NP
UT WOS:000235416300008
PM 16448990
OA Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Wester, VL
   van Rossum, EFC
AF Wester, Vincent L.
   van Rossum, Elisabeth F. C.
TI Clinical applications of cortisol measurements in hair
SO EUROPEAN JOURNAL OF ENDOCRINOLOGY
LA English
DT Review
ID LONG-TERM CORTISOL; POSTTRAUMATIC-STRESS-DISORDER; HYDROCORTISONE
   REPLACEMENT THERAPY; CYCLIC CUSHINGS-SYNDROME; PITUITARY-ADRENAL AXIS;
   BODY-MASS INDEX; SCALP HAIR; BIPOLAR DISORDER; HEALTHY-CHILDREN;
   MENTAL-HEALTH
AB Cortisol measurements in blood, saliva and urine are frequently used to examine the hypothalamus-pituitary-adrenal (HPA) axis in clinical practice and in research. However, cortisol levels are subject to variations due to acute stress, the diurnal rhythm and pulsatile secretion. Cortisol measurements in body fluids are not always a reflection of long-term cortisol exposure. The analysis of cortisol in scalp hair is a relatively novel method to measure cumulative cortisol exposure over months up to years. Over the past years, hair cortisol concentrations (HCC) have been examined in association with a large number of somatic and mental health conditions. HCC can be used to evaluate disturbances of the HPA axis, including Cushing's syndrome, and to evaluate hydrocortisone treatment. Using HCC, retrospective timelines of cortisol exposure can be created which can be of value in diagnosing cyclic hypercortisolism. HCC have also been shown to increase with psychological stressors, including major life events, as well as physical stressors, such as endurance exercise and shift work. Initial studies show that HCC may be increased in depression, but decreased in general anxiety disorder. In posttraumatic stress disorder, changes in HCC seem to be dependent on the type of traumatic experience and the time since traumatization. Increased hair cortisol is consistently linked to obesity, metabolic syndrome and cardiovascular disease. Potentially, HCC could form a future marker for cardiovascular risk stratification, as well as serve as a treatment target.
C1 [Wester, Vincent L.; van Rossum, Elisabeth F. C.] Erasmus MC, Univ Med Ctr Rotterdam, Dept Internal Med, Div Endocrinol, NL-3000 CA Rotterdam, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC
RP van Rossum, EFC (corresponding author), Erasmus MC, Room D428,POB 2040, NL-3000 CA Rotterdam, Netherlands.
EM e.vanrossum@erasmusmc.nl
RI van Rossum, Elisabeth/AAP-9388-2020
OI van Rossum, Elisabeth/0000-0003-0120-4913
FU Thrasher Research Fund [TRF11643]; Netherlands Brain Foundation
   [F2011(1)-12]; Erasmus MC Fellowship
FX The last author (E F C van Rossum) supported by the Thrasher Research
   Fund (TRF11643), The Netherlands Brain Foundation (grant number
   F2011(1)-12) and an Erasmus MC Fellowship.
CR Boesch M, 2015, STRESS, V18, P35, DOI 10.3109/10253890.2014.974028
   Braig S, 2015, PSYCHONEUROENDOCRINO, V52, P289, DOI 10.1016/j.psyneuen.2014.12.006
   Burke HM, 2005, PSYCHONEUROENDOCRINO, V30, P846, DOI 10.1016/j.psyneuen.2005.02.010
   Cooper GAA, 2012, FORENSIC SCI INT, V218, P20, DOI 10.1016/j.forsciint.2011.10.024
   D'Anna-Hernandez KL, 2011, PHYSIOL BEHAV, V104, P348, DOI 10.1016/j.physbeh.2011.02.041
   Dettenborn L, 2010, PSYCHONEUROENDOCRINO, V35, P1404, DOI 10.1016/j.psyneuen.2010.04.006
   Dettenborn L, 2012, STRESS, V15, P348, DOI 10.3109/10253890.2011.619239
   Dowlati Y, 2010, NEUROPSYCH DIS TREAT, V6, P393
   Ells LJ, 2006, OBES REV, V7, P341, DOI 10.1111/j.1467-789X.2006.00233.x
   Feller S, 2014, PSYCHONEUROENDOCRINO, V39, P132, DOI 10.1016/j.psyneuen.2013.10.007
   Friedman TC, 2010, HORM METAB RES, V42, P874, DOI 10.1055/s-0030-1263128
   Gao W, 2013, J CHROMATOGR B, V928, P1, DOI 10.1016/j.jchromb.2013.03.008
   Gao W, 2010, CLIN BIOCHEM, V43, P677, DOI 10.1016/j.clinbiochem.2010.01.014
   Goldberg SB, 2014, J ALTERN COMPLEM MED, V20, P630, DOI 10.1089/acm.2014.0080
   Gow R, 2011, CLIN ENDOCRINOL, V74, P687, DOI 10.1111/j.1365-2265.2011.04001.x
   Grass J, 2015, PSYCHONEUROENDOCRINO, V53, P108, DOI 10.1016/j.psyneuen.2014.12.023
   Grassi-Oliveira R, 2012, AM J DRUG ALCOHOL AB, V38, P535, DOI 10.3109/00952990.2012.694538
   Groeneveld MG, 2013, STRESS, V16, P711, DOI 10.3109/10253890.2013.817553
   Hellhammer DH, 2009, PSYCHONEUROENDOCRINO, V34, P163, DOI 10.1016/j.psyneuen.2008.10.026
   Holsboer F, 2000, NEUROPSYCHOPHARMACOL, V23, P477, DOI 10.1016/S0893-133X(00)00159-7
   Kalra S, 2007, CLIN INVEST MED, V30, pE103, DOI 10.25011/cim.v30i2.986
   Kamps AWA, 2014, ACTA PAEDIATR, V103, P957, DOI 10.1111/apa.12685
   Karlén J, 2011, BMC CLIN PATHOL, V11, DOI 10.1186/1472-6890-11-12
   Kirschbaum C, 2009, PSYCHONEUROENDOCRINO, V34, P32, DOI 10.1016/j.psyneuen.2008.08.024
   Loussouarn G, 2005, INT J DERMATOL, V44, P6, DOI 10.1111/j.1365-4632.2005.02800.x
   Luo HR, 2012, BIOL PSYCHIAT, V72, P65, DOI 10.1016/j.biopsych.2011.12.020
   Manenschijn L, 2014, HORM METAB RES, V46, P299, DOI 10.1055/s-0034-1370961
   Manenschijn L, 2013, J CLIN ENDOCR METAB, V98, P2078, DOI 10.1210/jc.2012-3663
   Manenschijn L, 2012, J CLIN ENDOCR METAB, V97, pE1836, DOI 10.1210/jc.2012-1852
   Manenschijn L, 2012, PSYCHONEUROENDOCRINO, V37, P1960, DOI 10.1016/j.psyneuen.2012.04.010
   Manenschijn L, 2011, J CLIN ENDOCR METAB, V96, pE1862, DOI 10.1210/jc.2011-1551
   Manenschijn L, 2011, STEROIDS, V76, P1032, DOI 10.1016/j.steroids.2011.04.005
   Meewisse ML, 2007, BRIT J PSYCHIAT, V191, P387, DOI 10.1192/bjp.bp.106.024877
   Meinardi JR, 2007, EUR J ENDOCRINOL, V157, P245, DOI 10.1530/EJE-07-0262
   Nieman LK, 2008, J CLIN ENDOCR METAB, V93, P1526, DOI 10.1210/jc.2008-0125
   Noppe G, 2014, CLIN ENDOCRINOL, V81, P820, DOI 10.1111/cen.12551
   Noppe G, 2015, CLIN ENDOCRINOL, V83, P162, DOI 10.1111/cen.12781
   Noppe G, 2014, HORM RES PAEDIAT, V82, P97, DOI 10.1159/000362519
   Pereg D, 2013, PSYCHONEUROENDOCRINO, V38, P2875, DOI 10.1016/j.psyneuen.2013.07.015
   Pereg D, 2011, STRESS, V14, P73, DOI 10.3109/10253890.2010.511352
   Quax RA, 2013, NAT REV ENDOCRINOL, V9, P670, DOI 10.1038/nrendo.2013.183
   Russell E, 2015, THER DRUG MONIT, V37, P71, DOI 10.1097/FTD.0000000000000148
   Russell E, 2014, THER DRUG MONIT, V36, P30, DOI 10.1097/FTD.0b013e31829daa0a
   Sauve B, 2007, CLIN INVEST MED, V30, pE183, DOI 10.25011/cim.v30i5.2894
   Schutz H, 1993, Pharm Unserer Zeit, V22, P65, DOI 10.1002/pauz.19930220205
   Skoluda N, 2012, PSYCHONEUROENDOCRINO, V37, P611, DOI 10.1016/j.psyneuen.2011.09.001
   Stalder T, 2014, PSYCHONEUROENDOCRINO, V47, P26, DOI 10.1016/j.psyneuen.2014.04.021
   Stalder T, 2013, J CLIN ENDOCR METAB, V98, P2573, DOI 10.1210/jc.2013-1056
   Stalder T, 2012, BIOL PSYCHOL, V90, P218, DOI 10.1016/j.biopsycho.2012.03.010
   Stalder T, 2012, PSYCHONEUROENDOCRINO, V37, P602, DOI 10.1016/j.psyneuen.2011.08.007
   Stalder T, 2010, BIOL PSYCHOL, V85, P357, DOI 10.1016/j.biopsycho.2010.08.005
   Staufenbiel SM, 2015, J CLIN ENDOCR METAB, V100, P2456, DOI 10.1210/jc.2014-4328
   Staufenbiel SM, 2014, STRESS, V17, P451, DOI 10.3109/10253890.2014.968549
   Staufenbiel SM, 2013, PSYCHONEUROENDOCRINO, V38, P1220, DOI 10.1016/j.psyneuen.2012.11.015
   Steinisch M, 2014, PSYCHONEUROENDOCRINO, V50, P20, DOI 10.1016/j.psyneuen.2014.08.001
   Steudte S, 2013, BIOL PSYCHIAT, V74, P639, DOI 10.1016/j.biopsych.2013.03.011
   Steudte S, 2011, PSYCHONEUROENDOCRINO, V36, P1193, DOI 10.1016/j.psyneuen.2011.02.012
   Steudte S, 2011, PSYCHIAT RES, V186, P310, DOI 10.1016/j.psychres.2010.09.002
   Thomson S, 2010, EXP CLIN ENDOCR DIAB, V118, P133, DOI 10.1055/s-0029-1220771
   Tiganescu A, 2011, J INVEST DERMATOL, V131, P30, DOI 10.1038/jid.2010.257
   Tsigos C, 2002, J PSYCHOSOM RES, V53, P865, DOI 10.1016/S0022-3999(02)00429-4
   van Rossum EFC, 2012, EXPERT REV ENDOCRINO, V7, P123, DOI [10.1586/eem.11.95, 10.1586/EEM.11.95]
   Van Uum SHM, 2008, STRESS, V11, P483, DOI 10.1080/10253890801887388
   Vanaelst B, 2013, EUR J PEDIATR, V172, P843, DOI 10.1007/s00431-013-1955-1
   Veldhorst MAB, 2014, J CLIN ENDOCR METAB, V99, P285, DOI 10.1210/jc.2013-2924
   Vreeburg SA, 2009, ARCH GEN PSYCHIAT, V66, P617, DOI 10.1001/archgenpsychiatry.2009.50
   Walker BR, 2007, EUR J ENDOCRINOL, V157, P545, DOI 10.1530/EJE-07-0455
   Wang L, 2015, BIOL PSYCHIAT, V77, pE21, DOI 10.1016/j.biopsych.2014.05.026
   Wells S, 2014, STRESS, V17, P334, DOI 10.3109/10253890.2014.930432
   Wester VL, 2014, OBESITY, V22, P1956, DOI 10.1002/oby.20795
   Wester VL, 2014, CURR OPIN ENDOCRINOL, V21, P306, DOI 10.1097/MED.0000000000000077
   Younge JO, 2015, INT J CARDIOL, V184, P71, DOI 10.1016/j.ijcard.2015.02.005
NR 72
TC 154
Z9 168
U1 0
U2 66
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0804-4643
EI 1479-683X
J9 EUR J ENDOCRINOL
JI Eur. J. Endocrinol.
PD OCT
PY 2015
VL 173
IS 4
BP M1
EP M10
DI 10.1530/EJE-15-0313
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CQ3HE
UT WOS:000360491900001
PM 25924811
DA 2025-06-11
ER

PT J
AU Ceci, FM
   Ferraguti, G
   Petrella, C
   Greco, A
   Tirassa, P
   Iannitelli, A
   Ralli, M
   Vitali, M
   Ceccanti, M
   Chaldakov, GN
   Versacci, P
   Fiore, M
AF Ceci, Flavio Maria
   Ferraguti, Giampiero
   Petrella, Carla
   Greco, Antonio
   Tirassa, Paola
   Iannitelli, Angela
   Ralli, Massimo
   Vitali, Mario
   Ceccanti, Mauro
   Chaldakov, George N.
   Versacci, Paolo
   Fiore, Marco
TI Nerve Growth Factor, Stress and Diseases
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Stress; Nerve Growth Factor (NGF); mental disorders; metabolic syndrome;
   alcohol use disorders; me-tabolism disorder
ID SCHISTOSOMA-MANSONI INFECTION; PASSIVE-AVOIDANCE RESPONSE; P75
   NEUROTROPHIN RECEPTOR; EARLY-LIFE STRESS; METABOLIC SYNDROME; BRAIN NGF;
   ANIMAL-MODELS; SERUM-LEVELS; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS
AB Stress is a constant threat for homeostasis and is represented by different extrinsic and intrinsic stimuli (stressors, Hans Selye's "noxious agents"), such as aggressive behavior, fear, diseases, physical activity, drugs, surgical injury, and environmental and physiological changes. Our organisms respond to stress by activating the adaptive stress system to activate compensatory responses for restoring homeostasis. Nerve Growth Factor (NGF) was discovered as a signaling molecule involved in survival, protection, differentiation, and proliferation of sympathetic and peripheral sensory neurons. NGF mediates stress with an important role in translating environmental stimuli into physiological and pathological feedbacks since NGF levels undergo important variations after exposure to stressful events. Psychological stress, lifestyle stress, and oxidative stress are well known to increase the risk of mental disorders such as schizophrenia, major depressive disorders, bipolar disorder, alcohol use disorders and metabolic disorders such as metabolic syndrome. This review reports recent works describing the activity of NGF in mental and metabolic disorders related to stress.
C1 [Ceci, Flavio Maria; Ferraguti, Giampiero] Sapienza Univ Rome, Dept Expt Med, Rome, Italy.
   [Petrella, Carla; Tirassa, Paola; Fiore, Marco] IBBC CNR, Inst Biochem & Cell Biol, Rome, Italy.
   [Greco, Antonio; Ralli, Massimo; Fiore, Marco] Sapienza Univ Rome, Dept Sense Organs, Viale Policlin 155, I-00161 Rome, Italy.
   [Iannitelli, Angela] Univ Aquila, Dept Biotechnol & Appl Clin Sci, Rome, Italy.
   [Vitali, Mario] AV4, ASUR Marche, Ancona, Italy.
   [Ceccanti, Mauro] ASL Roma 1, Ctr Riferimento Alcol Reg Lazio, Rome, Italy.
   [Chaldakov, George N.] Med Univ, Dept Anat & Cell Biol, Varna, Bulgaria.
   [Chaldakov, George N.] Inst Adv Study, Varna, Bulgaria.
   [Versacci, Paolo] Sapienza Univ Hosp Rome, Dept Pediat, Rome, Italy.
C3 Sapienza University Rome; Consiglio Nazionale delle Ricerche (CNR);
   Istituto di Biochimica e Biologia Cellulare (IBBC-CNR); Sapienza
   University Rome; University of L'Aquila; Medical University Varna;
   Sapienza University Rome
RP Fiore, M (corresponding author), IBBC CNR, Inst Biochem & Cell Biol, Rome, Italy.; Fiore, M (corresponding author), Sapienza Univ Rome, Dept Sense Organs, Viale Policlin 155, I-00161 Rome, Italy.
EM marcofiore.roma@gmail.com
RI Ceci, Flavio Maria/AAI-1510-2021; Ceccanti, Mauro/MVW-1162-2025;
   Petrella, Carla/AAX-1265-2020; Tirassa, Paola/JAO-0252-2023; Fiore,
   Marco/GLT-0780-2022; Ralli, Massimo/E-1780-2018
OI fiore, marco/0000-0001-6806-9715; Ceci, Flavio
   Maria/0000-0001-7744-218X; Petrella, Carla/0000-0003-0651-1816; greco,
   antonio/0000-0002-4824-9871; Ralli, Massimo/0000-0001-8776-0421;
   TIRASSA, PAOLA/0000-0002-8791-4424; FERRAGUTI,
   Giampiero/0000-0001-6129-4071
FU Sapienza Universita di Roma, Italy; IBBC-CNR [CNR 0002744-2017]
FX Authors thank Sapienza Universita di Roma, Italy and IBBC-CNR for
   supporting the study (Grant Number CNR 0002744-2017).
CR Abel EL, 2004, ADDICT BIOL, V9, P127, DOI 10.1080/13556210410001716980
   Ajami A, 2014, SCAND J IMMUNOL, V80, P36, DOI 10.1111/sji.12158
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Alleva E, 1993, Rev Neurosci, V4, P41
   ALOE L, 1990, BEHAV BRAIN RES, V39, P53, DOI 10.1016/0166-4328(90)90120-4
   Aloe L, 1999, CYTOKINE, V11, P45, DOI 10.1006/cyto.1998.0397
   ALOE L, 1994, AUTOIMMUNITY, V19, P141, DOI 10.3109/08916939409009542
   ALOE L, 1986, P NATL ACAD SCI USA, V83, P6184, DOI 10.1073/pnas.83.16.6184
   Aloe L, 1997, THYMUS, V24, P221, DOI 10.1023/A:1016990503061
   Aloe L, 2002, PHARMACOL BIOCHEM BE, V73, P159, DOI 10.1016/S0091-3057(02)00757-8
   ALOE L, 1994, BRAIN RES BULL, V33, P173, DOI 10.1016/0361-9230(94)90247-X
   ALOE L, 1994, P NATL ACAD SCI USA, V91, P10440, DOI 10.1073/pnas.91.22.10440
   Aloe L, 1997, PSYCHOPHARMACOLOGY, V134, P287, DOI 10.1007/s002130050451
   Aloe L, 1998, PARASITOL TODAY, V14, P314, DOI 10.1016/S0169-4758(98)01283-6
   Aloe L, 1996, ACTA NEUROPATHOL, V92, P300, DOI 10.1007/s004010050522
   Aloe L, 2000, AUTON NEUROSCI-BASIC, V86, P84, DOI 10.1016/S1566-0702(00)00247-2
   ALOE L, 1994, NEUROREPORT, V5, P1030, DOI 10.1097/00001756-199405000-00003
   Aloe L, 1996, ALCOHOL CLIN EXP RES, V20, P462, DOI 10.1111/j.1530-0277.1996.tb01076.x
   ALOE L, 1992, ALCOHOL, V9, P299, DOI 10.1016/0741-8329(92)90070-Q
   Aloe L, 2000, BEHAV PHARMACOL, V11, P235, DOI 10.1097/00008877-200006000-00007
   Amendola T, 2003, NEUROSCI LETT, V345, P37, DOI 10.1016/S0304-3940(03)00491-9
   Angelucci F, 1999, NEUROTOXICOL TERATOL, V21, P415, DOI 10.1016/S0892-0362(99)00005-7
   Angelucci F, 2005, MOL PSYCHIATR, V10, P345, DOI 10.1038/sj.mp.4001637
   [Anonymous], 2018, Handbook of Developmental Neurotoxicology (Numero March, DOI DOI 10.1016/B978-0-12-809405-1.00038-9
   [Anonymous], 2016, BIOMED REV
   [Anonymous], 2019, BIOMED REV, DOI DOI 10.14748/BMR.V30.6391
   [Anonymous], 2016, INTRO PAIN ITS RELAT, DOI DOI 10.1002/9781118455968.CH13
   [Anonymous], 2017, Biomed. Rev, DOI DOI 10.14748/BMR.V28.4452
   [Anonymous], 2018, Biomed. Rev, DOI DOI 10.14748/BMR.V29.5845
   Ans AH, 2018, CUREUS J MED SCIENCE, V10, DOI 10.7759/cureus.3032
   Ardic-Pulas T., 2016, AIDE SOIGNANTE, V30, P24, DOI [10.1016/j.aidsoi.2016.07.008, DOI 10.1016/J.AIDSOI.2016.07.008]
   Armutcu F, 2008, CLIN CHEM LAB MED, V46, P785, DOI 10.1515/CCLM.2008.166
   Aschbacher K, 2014, PSYCHONEUROENDOCRINO, V46, P14, DOI 10.1016/j.psyneuen.2014.04.003
   Badowska-Szalewska E, 2015, NEUROSCIENCE, V290, P346, DOI 10.1016/j.neuroscience.2015.01.052
   Bae H, 2014, NEUROPSYCH DIS TREAT, V10, P2153, DOI 10.2147/NDT.S72067
   BARDE YA, 1994, J NEUROBIOL, V25, P1329, DOI 10.1002/neu.480251102
   Becker HC, 2017, NEUROPHARMACOLOGY, V122, P115, DOI 10.1016/j.neuropharm.2017.04.028
   Becker HC, 2013, CURR TOP BEHAV NEURO, V13, P355, DOI 10.1007/7854_2012_203
   Becker K, 2018, VET PATHOL, V55, P786, DOI 10.1177/0300985818781930
   BENELIYAHU S, 1991, BRAIN BEHAV IMMUN, V5, P193, DOI 10.1016/0889-1591(91)90016-4
   Berry A, 2012, NEURAL PLAST, V2012, DOI 10.1155/2012/784040
   Bersani G, 1999, SCHIZOPHR RES, V37, P201
   Bersani G, 2000, MED HYPOTHESES, V55, P199, DOI 10.1054/mehy.1999.1044
   Bersani G, 2011, NEUROSCI LETT, V499, P170, DOI 10.1016/j.neulet.2011.05.046
   Blokken Jolien, 2017, Drug Discov Today Technol, V24, P25, DOI 10.1016/j.ddtec.2017.11.002
   Bolton JM, 2009, J AFFECT DISORDERS, V115, P367, DOI 10.1016/j.jad.2008.10.003
   Bonomini F, 2015, AGING DIS, V6, P109, DOI 10.14336/AD.2014.0305
   Bracci-Laudiero L, 2016, CURR TOP BEHAV NEURO, V29, P125, DOI 10.1007/7854_2015_420
   Braunger BM, 2014, ADV EXP MED BIOL, V801, P9, DOI 10.1007/978-1-4614-3209-8_2
   Bruscolini A, 2018, AUTOIMMUN REV, V17, P639, DOI 10.1016/j.autrev.2017.12.012
   Campos AC, 2014, NEUROSCI LETT, V578, P100, DOI 10.1016/j.neulet.2014.06.039
   Canever L, 2018, PROG NEURO-PSYCHOPH, V86, P52, DOI 10.1016/j.pnpbp.2018.05.014
   Cantor David., 2014, STRESS SHOCK ADAPTAT, P21
   Carito V, 2018, Biomed Rev, V29, P27, DOI 10.14748/bmr.v29.5847
   Carito V, 2019, CURR NEUROPHARMACOL, V17, P308, DOI 10.2174/1570159X15666170825101308
   Carito V, 2017, NUTRITION, V33, P65, DOI 10.1016/j.nut.2016.08.014
   Carito V, 2016, CURR MED CHEM, V23, P3189, DOI 10.2174/0929867323666160627104022
   Carito V, 2015, BIOACTIVE NUTRACEUTICALS AND DIETARY SUPPLEMENTS IN NEUROLOGICAL AND BRAIN DISEASE: PREVENTION AND THERAPY, P65, DOI 10.1016/B978-0-12-411462-3.00007-2
   Carrasco GA, 2003, EUR J PHARMACOL, V463, P235, DOI 10.1016/S0014-2999(03)01285-8
   Carvalho AF, 2019, LANCET, V394, P781, DOI 10.1016/S0140-6736(19)31775-1
   Ceccanti M, 2018, RIV PSICHIATR, V53, P105, DOI 10.1708/2925.29410
   Ceccanti M, 2018, CAN J PHYSIOL PHARM, V96, P128, DOI 10.1139/cjpp-2017-0013
   Ceccanti M, 2016, ADDICT BIOL, V21, P776, DOI 10.1111/adb.12255
   Ceccanti M, 2015, PHYSIOL BEHAV, V149, P324, DOI 10.1016/j.physbeh.2015.06.034
   Ceccanti M, 2013, ANN I SUPER SANITA, V49, P383, DOI 10.4415/ANN_13_04_11
   Ceccanti M, 2012, NEUROBIOL AGING, V33, P359, DOI 10.1016/j.neurobiolaging.2010.03.005
   Ceci FM, 2021, CURR NEUROPHARMACOL, V19, P45, DOI 10.2174/1570159X18666200429003239
   Chaldakov GN, 2007, CURR PHARM DESIGN, V13, P2176, DOI 10.2174/138161207781039616
   Chaldakov GN, 2006, LETT DRUG DES DISCOV, V3, P503, DOI 10.2174/157018006778194835
   Chaldakov GN, 2011, ARCH ITAL BIOL, V149, P257, DOI 10.4449/aib.v149i2.1366
   Chaldakov G N, 2001, Arch Physiol Biochem, V109, P357, DOI 10.1076/apab.109.3.357.9353
   Chaldakov G.N., 2010, ADPOBIOLOGY, V2, DOI [10.14748/adipo.v2.255, DOI 10.14748/ADIPO.V2.255]
   Chaldakov G.N., 2000, Int Med J, V7, P43
   Chaldakov G.N., 2014, MOL MECH UNDERPINNIN, P167, DOI [10.1007/978-3-319-12766-8_11, DOI 10.1007/978-3-319-12766-8_11]
   Chaldakov George N, 2003, Med Sci Monit, V9, pHY19
   Chaldakov GN, 2010, CELL BIOL INT, V34, P1051, DOI 10.1042/CBI20100509
   Chaldakov GN, 2014, FRONT IMMUNOL, V5, DOI 10.3389/fimmu.2014.00130
   Chaldakov GN, 2004, PROG BRAIN RES, V146, P279, DOI 10.1016/S0079-6123(03)46018-4
   Chaldakov GN, 2001, ATHEROSCLEROSIS, V159, P57, DOI 10.1016/S0021-9150(01)00488-9
   Chang CK, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2013-004295
   Chrousos GP, 2009, NAT REV ENDOCRINOL, V5, P374, DOI 10.1038/nrendo.2009.106
   CHROUSOS GP, 1992, JAMA-J AM MED ASSOC, V267, P1244, DOI 10.1001/jama.267.9.1244
   Chuenkova MV, 2011, ADV PARASIT, V76, P195, DOI 10.1016/B978-0-12-385895-5.00009-8
   Chuenkova MV, 2004, J NEUROCHEM, V91, P385, DOI 10.1111/j.1471-4159.2004.02724.x
   Chuenkova MV, 2001, NEUROREPORT, V12, P3715, DOI 10.1097/00001756-200112040-00022
   Chul BL, 2009, ALCOHOL, V43, P265, DOI 10.1016/j.alcohol.2009.04.003
   CIAFRE S, 2018, BIOMED REV, V28, P49, DOI DOI 10.14748/BMR.V28.4451
   Ciafrè S, 2020, NEUROSCI BIOBEHAV R, V118, P654, DOI 10.1016/j.neubiorev.2020.08.018
   Ciafrè S, 2020, RIV PSICHIATR, V55, P4, DOI 10.1708/3301.32713
   Ciafrè S, 2019, BIOCHEM CELL BIOL, V97, P345, DOI 10.1139/bcb-2018-0248
   Cirulli F, 2009, FRONT NEUROENDOCRIN, V30, P379, DOI 10.1016/j.yfrne.2009.05.002
   Conway KP, 2016, J AM ACAD CHILD PSY, V55, P280, DOI 10.1016/j.jaac.2016.01.006
   Coriale G, 2020, CLIN TER, V171, pE120, DOI 10.7417/CT.2020.2201
   Coriale G, 2013, RIV PSICHIATR, V48, P359, DOI 10.1708/1356.15062
   Coulson EJ, 2004, PROG BRAIN RES, V146, P41, DOI 10.1016/S0079-6123(03)46003-2
   Cuijpers P, 2014, AM J PSYCHIAT, V171, P453, DOI 10.1176/appi.ajp.2013.13030325
   D'Angelo A, 2020, EUR J OBSTET GYN R B, V247, P32, DOI 10.1016/j.ejogrb.2020.01.046
   Dayas CV, 2001, EUR J NEUROSCI, V14, P1143, DOI 10.1046/j.0953-816x.2001.01733.x
   de Kloet ER, 2005, NAT REV NEUROSCI, V6, P463, DOI 10.1038/nrn1683
   De Nicolo S., 2014, CURR DEV DISORD REP, V1, P173, DOI 10.1007/s40474-014-0023-5
   De Santis S, 2000, CLIN CANCER RES, V6, P90
   Deponti D, 2009, MOL BIOL CELL, V20, P3620, DOI 10.1091/mbc.E09-01-0012
   Di Fausto V, 2007, EUR J NEUROSCI, V26, P2473, DOI 10.1111/j.1460-9568.2007.05883.x
   Di Fausto V, 2007, NEUROTOXICOL TERATOL, V29, P273, DOI 10.1016/j.ntt.2006.10.007
   Duman RS, 1997, ARCH GEN PSYCHIAT, V54, P597
   Eisfeld J., 2014, Transgender Studies Quarterly, V1, P107, DOI DOI 10.1215/23289252-2399740
   Enoch MA, 2011, PSYCHOPHARMACOLOGY, V214, P17, DOI 10.1007/s00213-010-1916-6
   Fernandes BS, 2015, MOL PSYCHIATR, V20, P1108, DOI 10.1038/mp.2014.117
   Ferraguti G, 2020, ADDICT BIOL, V25, DOI 10.1111/adb.12724
   Ferraguti G, 2015, CURR MED CHEM, V22, P670, DOI 10.2174/0929867321666141229103158
   Filho CB, 2015, NEUROSCIENCE, V289, P367, DOI 10.1016/j.neuroscience.2014.12.048
   Fiore M, 1998, PHYSIOL BEHAV, V63, P571, DOI 10.1016/S0031-9384(97)00514-3
   Fiore M, 1999, NEUROPHARMACOLOGY, V38, P857, DOI 10.1016/S0028-3908(99)00007-6
   Fiore M, 1997, PHYSIOL BEHAV, V62, P399, DOI 10.1016/S0031-9384(97)00036-X
   Fiore M, 1996, EXP PARASITOL, V83, P46, DOI 10.1006/expr.1996.0047
   Fiore M, 2005, BEHAV BRAIN RES, V157, P351, DOI 10.1016/j.bbr.2004.08.024
   Fiore M, 2004, NEUROREPORT, V15, P1791, DOI 10.1097/01.wnr.0000135934.03635.6a
   Fiore M, 2001, Arch Physiol Biochem, V109, P361, DOI 10.1076/apab.109.4.361.4247
   Fiore M, 2003, EUR J NEUROSCI, V17, P1455, DOI 10.1046/j.1460-9568.2003.02573.x
   Fiore M, 2002, PHYSIOL BEHAV, V75, P449, DOI 10.1016/S0031-9384(01)00661-8
   Fiore M, 2002, PHYSIOL BEHAV, V77, P437, DOI 10.1016/S0031-9384(02)00875-2
   Fiore M, 2002, NEUROTOXICOL TERATOL, V24, P179, DOI 10.1016/S0892-0362(01)00214-8
   Fiore M, 2001, NEUROSCI LETT, V309, P113, DOI 10.1016/S0304-3940(01)02045-6
   Fiore M, 1999, BEHAV BRAIN RES, V101, P85, DOI 10.1016/S0166-4328(98)00143-0
   Fiore M, 2009, NEUROTOXICOLOGY, V30, P59, DOI 10.1016/j.neuro.2008.11.009
   Fiore M, 2020, J FUNCT FOODS, V71, DOI 10.1016/j.jff.2020.104012
   Fiore M, 2009, REV NEUROSCIENCE, V20, P133
   Fiore M, 2008, ANN I SUPER SANITA, V44, P167
   Fiore M, 2009, TOXICOL LETT, V188, P208, DOI 10.1016/j.toxlet.2009.04.013
   Galvez-Contreras AY, 2016, CYTOKINE GROWTH F R, V32, P85, DOI 10.1016/j.cytogfr.2016.08.004
   Ghaemi SN, 2006, CURR OPIN PSYCHIATR, V19, P619, DOI 10.1097/01.yco.0000245751.98749.52
   Gioiosa L, 2009, RIV PSICHIATR, V44, P88, DOI 10.1708/420.4978
   Glaser R, 2005, NAT REV IMMUNOL, V5, P243, DOI 10.1038/nri1571
   Godoy LD, 2018, FRONT BEHAV NEUROSCI, V12, DOI 10.3389/fnbeh.2018.00127
   Golbidi S, 2015, AM J PHYSIOL-HEART C, V308, pH1476, DOI 10.1152/ajpheart.00859.2014
   Goodin BR, 2012, BIOL PSYCHOL, V91, P36, DOI 10.1016/j.biopsycho.2012.02.020
   Greenwood-Van Meerveld B, 2017, HANDB EXP PHARMACOL, V239, P1, DOI 10.1007/164_2016_118
   Hansson AC, 2008, EUR J NEUROSCI, V27, P1912, DOI 10.1111/j.1460-9568.2008.06159.x
   Harrison PJ, 2018, TRENDS NEUROSCI, V41, P18, DOI 10.1016/j.tins.2017.10.006
   Heaton MB, 2000, J NEUROBIOL, V45, P95, DOI 10.1002/1097-4695(20001105)45:2<95::AID-NEU4>3.0.CO;2-Y
   Heberlein A, 2008, PSYCHONEUROENDOCRINO, V33, P999, DOI 10.1016/j.psyneuen.2008.05.011
   Heberlein A, 2013, ADDICT BIOL, V18, P508, DOI 10.1111/j.1369-1600.2010.00307.x
   Herman JP, 2016, COMPR PHYSIOL, V6, P603, DOI 10.1002/cphy.c150015
   Hirose M, 2016, PAIN PRACT, V16, P175, DOI 10.1111/papr.12342
   Hristova M, 2006, MED HYPOTHESES, V66, P545, DOI 10.1016/j.mehy.2005.08.055
   Huang EJ, 2003, ANNU REV BIOCHEM, V72, P609, DOI 10.1146/annurev.biochem.72.121801.161629
   Iannitelli A, 2017, NEUROSCI BIOBEHAV R, V80, P414, DOI 10.1016/j.neubiorev.2017.06.010
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Iwabuchi SJ, 2014, EUR NEUROPSYCHOPHARM, V24, P1784, DOI 10.1016/j.euroneuro.2014.08.005
   James SL, 2018, LANCET, V392, P1789, DOI [10.1016/s0140-6736(18)32335-3, 10.1016/S0140-6736(18)32335-3]
   Joëls M, 2009, NAT REV NEUROSCI, V10, P459, DOI 10.1038/nrn2632
   Kale A, 2009, SCHIZOPHR RES, V115, P209, DOI 10.1016/j.schres.2009.07.022
   KAPLAN DR, 1991, NATURE, V350, P158, DOI 10.1038/350158a0
   Kivimäki M, 2018, NAT REV CARDIOL, V15, P215, DOI 10.1038/nrcardio.2017.189
   Köhler S, 2013, EUR ADDICT RES, V19, P98, DOI 10.1159/000342334
   Koob GF, 2008, ANNU REV PSYCHOL, V59, P29, DOI 10.1146/annurev.psych.59.103006.093548
   Koob GF, 2014, NEUROPHARMACOLOGY, V76, P370, DOI 10.1016/j.neuropharm.2013.05.024
   Koob GF, 2010, NEUROPSYCHOPHARMACOL, V35, P217, DOI 10.1038/npp.2009.110
   Laaksonen DE, 2002, AM J EPIDEMIOL, V156, P1070, DOI 10.1093/aje/kwf145
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   LEVIMONTALCINI R, 1951, J EXP ZOOL, V116, P321, DOI 10.1002/jez.1401160206
   LEVIMONTALCINI R, 1987, SCIENCE, V237, P1154, DOI 10.1126/science.3306916
   Liu XH, 2014, PSYCHIAT RES, V218, P54, DOI 10.1016/j.psychres.2014.03.042
   Loi M, 2017, NEUROSCIENCE, V342, P101, DOI 10.1016/j.neuroscience.2015.08.024
   Lupien SJ, 1997, BRAIN RES REV, V24, P1, DOI 10.1016/S0165-0173(97)00004-0
   Lupien SJ, 2009, NAT REV NEUROSCI, V10, P434, DOI 10.1038/nrn2639
   Magnavita N, 2014, RADIOL MED, V119, P142, DOI 10.1007/s11547-013-0329-0
   Manni L, 2008, CURR NEUROVASC RES, V5, P1, DOI 10.2174/156720208783565654
   Manni L, 2009, PHYSIOL BEHAV, V98, P537, DOI 10.1016/j.physbeh.2009.08.011
   Martellucci S, 2021, EUR ARCH OTO-RHINO-L, V278, P41, DOI 10.1007/s00405-020-06052-1
   Martino M, 2013, PSYCHONEUROENDOCRINO, V38, P1824, DOI 10.1016/j.psyneuen.2013.02.009
   McEwen BS, 2015, NAT NEUROSCI, V18, P1353, DOI 10.1038/nn.4086
   Meeker RB, 2015, NEURAL REGEN RES, V10, P721, DOI 10.4103/1673-5374.156967
   Messina MP, 2020, RIV PSICHIATR, V55, P79, DOI 10.1708/3333.33022
   Miller JW, 2007, PEDIATRICS, V119, P76, DOI 10.1542/peds.2006-1517
   Minnone G, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18051028
   MOHAMMED AK, 1990, BRAIN RES, V528, P62, DOI 10.1016/0006-8993(90)90195-H
   Moore DB, 2004, J NEUROBIOL, V60, P101, DOI 10.1002/neu.20009
   Müller M, 2015, PSYCHIAT RES, V228, P251, DOI 10.1016/j.psychres.2015.06.034
   Neugebauer K, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00275
   Nicolaides NC, 2015, NEUROIMMUNOMODULAT, V22, P6, DOI 10.1159/000362736
   Niewiadomska G, 2011, BEHAV BRAIN RES, V221, P515, DOI 10.1016/j.bbr.2010.02.024
   Niewiadomska G, 2009, PROG NEURO-PSYCHOPH, V33, P791, DOI 10.1016/j.pnpbp.2009.03.039
   NIH, 2014, SCHIZOPHRENIA
   Pacitti F, 2011, RIV PSICHIATR, V46, P195, DOI 10.1708/889.9810
   Palmieri VO, 2006, J NUTR, V136, P3022, DOI 10.1093/jn/136.12.3022
   Parnanzone S, 2017, RIV PSICHIATR, V52, P49, DOI 10.1708/2679.27441
   Patrick ME, 2013, JAMA PEDIATR, V167, P1019, DOI 10.1001/jamapediatrics.2013.2392
   Peleshok J, 2006, BIOCHEM SOC T, V34, P612, DOI 10.1042/BST0340612
   Petrella C, 2020, NUTRITION, V79-80, DOI 10.1016/j.nut.2020.110783
   Piano MR, 2017, ALCOHOL RES-CURR REV, V38, P219
   Pratt LA, 2016, GEN HOSP PSYCHIAT, V39, P39, DOI 10.1016/j.genhosppsych.2015.12.003
   Pyykkönen AJ, 2010, DIABETES CARE, V33, P378, DOI 10.2337/dc09-1027
   Rao S, 2017, J PSYCHIATR RES, V86, P39, DOI 10.1016/j.jpsychires.2016.11.012
   Reichardt LF, 2006, PHILOS T R SOC B, V361, P1545, DOI 10.1098/rstb.2006.1894
   Reús GZ, 2011, NEUROCHEM RES, V36, P460, DOI 10.1007/s11064-010-0364-3
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Rosso P, 2020, NEUROSCI BIOBEHAV R, V113, P338, DOI 10.1016/j.neubiorev.2020.03.034
   Rozanski A, 1999, CIRCULATION, V99, P2192, DOI 10.1161/01.CIR.99.16.2192
   Russell J., 2015, Neuroendocrinology of Stress
   Samokhvalov AV, 2010, ALCOHOL CLIN EXP RES, V34, P1871, DOI 10.1111/j.1530-0277.2010.01275.x
   Santini I, 2016, RIV PSICHIATR, V51, P37, DOI 10.1708/2168.23452
   Schwarzinger M, 2017, BMC PUBLIC HEALTH, V18, DOI 10.1186/s12889-017-4587-y
   Seabold GK, 1998, DEV BRAIN RES, V108, P139, DOI 10.1016/S0165-3806(98)00043-1
   Sinha Rajita, 2007, Curr Psychiatry Rep, V9, P388, DOI 10.1007/s11920-007-0050-6
   Sinson G, 1997, J NEUROSURG, V86, P511, DOI 10.3171/jns.1997.86.3.0511
   Smith MA, 1996, BEHAV BRAIN RES, V78, P25, DOI 10.1016/0166-4328(95)00220-0
   Socci V, 2020, J PSYCHOPATHOL, V26, P92, DOI 10.36148/2284-0249-375
   Sornelli F, 2009, GEN PHYSIOL BIOPHYS, V28, P179
   Spahis S, 2017, ANTIOXID REDOX SIGN, V26, P445, DOI 10.1089/ars.2016.6756
   Steptoe A, 2013, ANNU REV PUBL HEALTH, V34, P337, DOI 10.1146/annurev-publhealth-031912-114452
   STREETEN DHP, 1984, ENDOCR REV, V5, P371, DOI 10.1210/edrv-5-3-371
   Sun Q, 2018, MED SCI MONITOR, V24, P5943, DOI 10.12659/MSM.909449
   Talevi D, 2018, CHILD ABUSE NEGLECT, V86, P349, DOI 10.1016/j.chiabu.2018.08.017
   Thome J, 1998, J NEURAL TRANSM, V105, P85, DOI 10.1007/s007020050040
   Tilbrook AJ, 2000, REV REPROD, V5, P105, DOI 10.1530/ror.0.0050105
   Tirassa P, 2003, J NEUROSCI RES, V72, P557, DOI 10.1002/jnr.10614
   Toda M, 2005, ARCH ENVIRON OCCUP H, V60, P266, DOI 10.3200/AEOH.60.5.266-269
   Tore F., 2007, Immunology Endocrine & Metabolic Agents in Medicinal Chemistry, V7, P149, DOI 10.2174/187152207780363712
   Tost H, 2015, NAT NEUROSCI, V18, P1421, DOI 10.1038/nn.4108
   Triaca V, 2019, AGING-US, V11, P11770, DOI 10.18632/aging.102499
   Ulrich-Lai YM, 2009, NAT REV NEUROSCI, V10, P397, DOI 10.1038/nrn2647
   Vengeliene V, 2008, BRIT J PHARMACOL, V154, P299, DOI 10.1038/bjp.2008.30
   Walker ER, 2018, CURR PSYCHIAT REP, V20, DOI 10.1007/s11920-018-0956-1
   Walker ER, 2017, DRUG ALCOHOL DEPEN, V171, P31, DOI 10.1016/j.drugalcdep.2016.11.026
   Weickert CS, 2003, MOL PSYCHIATR, V8, P592, DOI 10.1038/sj.mp.4001308
   Westman J, 2013, BMJ OPEN, V3, DOI 10.1136/bmjopen-2012-002373
   WHO, 2015, WORLD MENT HLTH 2014
   Xiong P, 2014, J CLIN PSYCHIAT, V75, pE794, DOI 10.4088/JCP.13m08772
   Yang LF, 2015, CURR NEUROPHARMACOL, V13, P494, DOI 10.2174/1570159X1304150831150507
   Yaribeygi H, 2017, EXCLI J, V16, P1057, DOI 10.17179/excli2017-480
   Yuen EC, 1996, ANN NEUROL, V40, P346, DOI 10.1002/ana.410400304
   Zakharyan R, 2014, BBA CLIN, V1, P24, DOI 10.1016/j.bbacli.2014.05.001
   Zelzer S, 2011, CLIN CHIM ACTA, V412, P1345, DOI 10.1016/j.cca.2011.03.031
NR 234
TC 41
Z9 41
U1 0
U2 19
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2021
VL 28
IS 15
BP 2943
EP 2959
DI 10.2174/0929867327999200818111654
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA TI4BQ
UT WOS:000672742400003
PM 32811396
DA 2025-06-11
ER

PT J
AU McClain, CJ
   Mokshagundam, PL
   Barve, SS
   Song, ZY
   Hill, DB
   Chen, T
   Deaciuc, I
AF McClain, CJ
   Mokshagundam, PL
   Barve, SS
   Song, ZY
   Hill, DB
   Chen, T
   Deaciuc, I
TI Mechanisms of non-alcoholic steatohepatitis
SO ALCOHOL
LA English
DT Article; Proceedings Paper
CT Symposium on Role of Fatty Liver Dietary Fatty Acid Supplements and
   Obesity in the Progression of Alcoholic Liver Disease
CY OCT 03, 2003
CL Bethesda, MD
DE non-alcoholic steatohepatitis; fatty liver; cytokines; mitochondria;
   oxidative stress
ID TUMOR-NECROSIS-FACTOR; FATTY LIVER-DISEASE; TYPE-2 DIABETIC-PATIENTS;
   INDUCED HEPATIC-INJURY; INSULIN-RESISTANCE; S-ADENOSYLMETHIONINE;
   FACTOR-ALPHA; METABOLIC SYNDROME; OXIDATIVE STRESS; ALCOHOLIC HEPATITIS
AB In 1980, the term non-alcoholic steatohepatitis was coined to describe a new syndrome occurring in patients who usually were obese (often diabetic) females who had a liver biopsy picture consistent with alcoholic hepatitis, but who denied alcohol use. The causes of this syndrome were unknown, and there was no defined therapy. More than two decades later, this clinical syndrome is only somewhat better understood, and still there is no Food and Drug Administration-approved or even generally accepted drug therapy. Patients with primary non-alcoholic steatohepatitis typically have the insulin resistance syndrome (synonymous with the metabolic syndrome, syndrome X, and so forth), which is characterized by obesity, diabetes, hyperlipidemia, hypertension, and, in some instances, other metabolic abnormalities such as polycystic ovary disease. Secondary non-alcoholic steatohepatitis may be caused by drugs such as tamoxifen, certain industrial toxins, rapid weight loss, and so forth. The cause of non-alcoholic steatohepatitis remains elusive, but most investigators agree that a baseline of steatosis requires a second hit capable of inducing inflammation, fibrosis, or necrosis for non-alcoholic steatohepatitis to develop. Our research group has focused its efforts on the interactions of nutritional abnormalities, cytokines, oxidative stress with lipid peroxidation, and mitochondrial dysfunction in the induction of steatohepatitis, both alcoholic and non-alcoholic in origin. Research findings from other laboratories also support the role of increased cytokine activity, oxidative stress, and mitochondrial dysfunction in the pathogenesis of non-alcohofic steatohepatitis. The objectives of this article are to review the (1) definition and clinical features of non-alcoholic steatohepatitis, (2) potential mechanisms of non-alcoholic steatohepatitis, and (3) potential therapeutic interventions in non-alcoholic steatohepatitis. (C) 2005 Elsevier Inc. All rights reserved.
C1 Univ Louisville, Ctr Med, Dept Internal Med, Louisville, KY 40292 USA.
   Univ Louisville, Hlth Sci Ctr, Dept Pharmacol & Toxicol, Louisville, KY 40202 USA.
C3 University of Louisville; University of Louisville
RP Univ Louisville, Ctr Med, Dept Internal Med, 530 S Jackson St,ACB 3rd Floor, Louisville, KY 40292 USA.
EM craig.mcclain@louisville.edu
RI Barve, Sunita/GRN-8021-2022
FU NIAAA NIH HHS [AA014185, AA000297, AA013170, AA010496, AA010762] Funding
   Source: Medline
CR Abdelmalek MF, 2001, AM J GASTROENTEROL, V96, P2711
   Akriviadis E, 2000, GASTROENTEROLOGY, V119, P1637, DOI 10.1053/gast.2000.20189
   Bajaj M, 2004, J CLIN ENDOCR METAB, V89, P200, DOI 10.1210/jc.2003-031315
   Bajaj M, 2003, DIABETES, V52, P1364, DOI 10.2337/diabetes.52.6.1364
   BANERJI MA, 1995, INT J OBESITY, V19, P846
   Barak AJ, 2003, J NUTR, V133, P2845, DOI 10.1093/jn/133.9.2845
   Berg AH, 2001, NAT MED, V7, P947, DOI 10.1038/90992
   Boison D, 2002, P NATL ACAD SCI USA, V99, P6985, DOI 10.1073/pnas.092642899
   Brunt EM, 2001, SEMIN LIVER DIS, V21, P3, DOI 10.1055/s-2001-12925
   Bugianesi E, 2004, HEPATOLOGY, V39, P179, DOI 10.1002/hep.20023
   Caldwell SH, 2001, AM J GASTROENTEROL, V96, P519
   Chalasani N, 2003, AM J GASTROENTEROL, V98, P1849, DOI 10.1016/S0002-9270(03)00510-0
   Chalasani N, 2003, AM J GASTROENTEROL, V98, P2771, DOI [10.1016/j.amjgastroenterol.2003.09.037, 10.1111/j.1572-0241.2003.08767.x]
   Chavin KD, 1999, J BIOL CHEM, V274, P5692, DOI 10.1074/jbc.274.9.5692
   Chawla RK, 1998, AM J PHYSIOL-GASTR L, V275, pG125, DOI 10.1152/ajpgi.1998.275.1.G125
   CHAWLA RK, 1984, GASTROENTEROLOGY, V87, P770
   Chen JJ, 1998, BBA-GEN SUBJECTS, V1380, P336, DOI 10.1016/S0304-4165(98)00002-6
   Chitturi S, 2001, SEMIN LIVER DIS, V21, P27, DOI 10.1055/s-2001-12927
   Chitturi Shivakumar, 2003, Curr Gastroenterol Rep, V5, P18, DOI 10.1007/s11894-003-0005-y
   CORKEY BE, 1988, J CLIN INVEST, V82, P782, DOI 10.1172/JCI113679
   Cortez-Pinto H, 1999, JAMA-J AM MED ASSOC, V282, P1659, DOI 10.1001/jama.282.17.1659
   Cortez-Pinto H, 1999, CLIN NUTR, V18, P353, DOI 10.1016/S0261-5614(99)80015-6
   Crespo J, 2001, HEPATOLOGY, V34, P1158, DOI 10.1053/jhep.2001.29628
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   DUCE AM, 1988, HEPATOLOGY, V8, P65, DOI 10.1002/hep.1840080113
   Eastin CE, 1997, ALCOHOL CLIN EXP RES, V21, P1037, DOI 10.1111/j.1530-0277.1997.tb04250.x
   Emery MG, 2003, HEPATOLOGY, V38, P428, DOI 10.1053/jhep.2003.50342
   Falck-Ytter Y, 2001, SEMIN LIVER DIS, V21, P17, DOI 10.1055/s-2001-12926
   Fargion S, 2001, AM J GASTROENTEROL, V96, P2448, DOI 10.1111/j.1572-0241.2001.04052.x
   Fernández-Real JM, 2002, DIABETES, V51, P2348, DOI 10.2337/diabetes.51.8.2348
   Fromenty B, 1997, J HEPATOL, V26, P43, DOI 10.1016/S0168-8278(97)80496-5
   FROMENTY B, 1995, PHARMACOL THERAPEUT, V67, P101, DOI 10.1016/0163-7258(95)00012-6
   Garg A, 2002, J CLIN ENDOCR METAB, V87, P3019, DOI 10.1210/jcem.87.7.8736
   George J, 2003, J HEPATOL, V39, P756, DOI 10.1016/S0168-8278(03)00376-3
   GRUNFELD C, 1990, ENDOCRINOLOGY, V127, P46, DOI 10.1210/endo-127-1-46
   Hasegawa T, 2001, ALIMENT PHARM THERAP, V15, P1667, DOI 10.1046/j.1365-2036.2001.01083.x
   Hill DB, 1999, CLIN BIOCHEM, V32, P563, DOI 10.1016/S0009-9120(99)00056-9
   HONCHEL R, 1992, ALCOHOL CLIN EXP RES, V16, P665, DOI 10.1111/j.1530-0277.1992.tb00656.x
   HOROWITZ JH, 1981, GASTROENTEROLOGY, V81, P668
   Iimuro Y, 1997, HEPATOLOGY, V26, P1530
   Ji C, 2003, GASTROENTEROLOGY, V124, P1488, DOI 10.1016/S0016-5085(03)00276-2
   Jialal I, 2003, CIRCULATION, V107, P926, DOI 10.1161/01.CIR.0000048966.26216.4C
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   KERR SJ, 1972, J BIOL CHEM, V247, P4248
   Knobler H, 1999, QJM-MON J ASSOC PHYS, V92, P73, DOI 10.1093/qjmed/92.2.73
   Koteish A, 2002, BEST PRACT RES CL GA, V16, P679, DOI 10.1053/bega.2002.0332
   Kugelmas M, 2003, HEPATOLOGY, V38, P413, DOI 10.1053/jhep.2003.50316
   Lavine JE, 2000, J PEDIATR-US, V136, P734, DOI 10.1016/S0022-3476(00)05040-X
   LEE KS, 1995, J CLIN INVEST, V96, P2461, DOI 10.1172/JCI118304
   Li ZP, 2003, HEPATOLOGY, V37, P343, DOI 10.1053/jhep.2003.50048
   Lieber C S, 1997, Adv Pharmacol, V38, P601
   Lin HZ, 2000, NAT MED, V6, P998, DOI 10.1038/79697
   Lu SC, 2001, P NATL ACAD SCI USA, V98, P5560, DOI 10.1073/pnas.091016398
   LUDWIG J, 1980, MAYO CLIN PROC, V55, P434
   Luyckx FH, 2000, DIABETES METAB, V26, P98
   Manton ND, 2000, MED J AUSTRALIA, V173, P476, DOI 10.5694/j.1326-5377.2000.tb139299.x
   Marceau P, 1999, J CLIN ENDOCR METAB, V84, P1513, DOI 10.1210/jc.84.5.1513
   Marchesini G, 2003, HEPATOLOGY, V37, P917, DOI 10.1053/jhep.2003.50161
   Marchesini G, 1999, AM J MED, V107, P450, DOI 10.1016/S0002-9343(99)00271-5
   Marchesini G, 2001, DIABETES, V50, P1844, DOI 10.2337/diabetes.50.8.1844
   Marchesini G, 2001, LANCET, V358, P893, DOI 10.1016/S0140-6736(01)06042-1
   Mato JM, 1997, PHARMACOL THERAPEUT, V73, P265, DOI 10.1016/S0163-7258(96)00197-0
   Mato JM, 1999, J HEPATOL, V30, P1081, DOI 10.1016/S0168-8278(99)80263-3
   Mato JM, 2002, FASEB J, V16, P15, DOI 10.1096/fj.01-0401rev
   MATO JM, 1997, LIVER BIOL PATHOBIOL, P461
   Mayerson AB, 2002, DIABETES, V51, P797, DOI 10.2337/diabetes.51.3.797
   McClain CJ, 1999, SEMIN LIVER DIS, V19, P205, DOI 10.1055/s-2007-1007110
   McClain CJ, 2002, ALCOHOL, V27, P185, DOI 10.1016/S0741-8329(02)00224-0
   MCCLAIN CJ, 1989, HEPATOLOGY, V9, P349, DOI 10.1002/hep.1840090302
   Memon RA, 1998, AM J PHYSIOL-ENDOC M, V274, pE210, DOI 10.1152/ajpendo.1998.274.2.E210
   Mendler MH, 1999, GASTROENTEROLOGY, V117, P1155, DOI 10.1016/S0016-5085(99)70401-4
   Morrow JD, 2003, ARTERIOSCL THROM VAS, V23, P368, DOI 10.1161/01.ATV.0000063107.86298.FD
   NESHER M, 1994, BBA-MOL CELL RES, V1221, P66, DOI 10.1016/0167-4889(94)90217-8
   Neuschwander-Tetri BA, 2003, HEPATOLOGY, V38, P1008, DOI 10.1053/jhep.2003.50420
   Nygard O, 1997, NEW ENGL J MED, V337, P230, DOI 10.1056/NEJM199707243370403
   Oliveira CPMS, 2002, J CELL MOL MED, V6, P399, DOI 10.1111/j.1582-4934.2002.tb00518.x
   PALMER M, 1990, GASTROENTEROLOGY, V99, P1408, DOI 10.1016/0016-5085(90)91169-7
   Pérez-Carreras M, 2003, HEPATOLOGY, V38, P999, DOI 10.1053/jhep.2003.50398
   Promrat K, 2004, HEPATOLOGY, V39, P188, DOI 10.1002/hep.20012
   Röhl M, 2004, J CLIN INVEST, V113, P474, DOI 10.1172/JCI200418712
   Ryysy L, 2000, DIABETES, V49, P749, DOI 10.2337/diabetes.49.5.749
   SanchezGongora E, 1997, FASEB J, V11, P1013, DOI 10.1096/fasebj.11.12.9337154
   Santamaría E, 2003, P NATL ACAD SCI USA, V100, P3065, DOI 10.1073/pnas.0536625100
   Sanyal AJ, 2001, GASTROENTEROLOGY, V120, P1183, DOI 10.1053/gast.2001.23256
   Schwahn B, 2001, Am J Pharmacogenomics, V1, P189, DOI 10.2165/00129785-200101030-00004
   Schwahn BC, 2003, FASEB J, V17, P512, DOI 10.1096/fj.02-0456fje
   SHERRATT HSA, 1986, TRENDS PHARMACOL SCI, V7, P186, DOI 10.1016/0165-6147(86)90310-X
   Sheth SG, 1997, ANN INTERN MED, V126, P137, DOI 10.7326/0003-4819-126-2-199701150-00008
   Song ZY, 2004, HEPATOLOGY, V40, P989, DOI 10.1002/hep.20412
   Sreekumar R, 2003, HEPATOLOGY, V38, P244, DOI 10.1053/jhep.2003.50290
   Sumida Y, 2003, J HEPATOL, V38, P32, DOI 10.1016/S0168-8278(02)00331-8
   Tilg H, 2000, NEW ENGL J MED, V343, P1467, DOI 10.1056/NEJM200011163432007
   Ueno T, 1997, J HEPATOL, V27, P103, DOI 10.1016/S0168-8278(97)80287-5
   Wigg AJ, 2001, GUT, V48, P206, DOI 10.1136/gut.48.2.206
   WOITCZAK L, 1993, BIOCHIM BIOPHYS ACTA, V1183, P41, DOI 10.1016/0005-2728(93)90004-Y
   Xu AM, 2003, J CLIN INVEST, V112, P91, DOI 10.1172/JCI200317797
   Yang SQ, 1997, P NATL ACAD SCI USA, V94, P2557, DOI 10.1073/pnas.94.6.2557
   Ye JM, 2003, AM J PHYSIOL-ENDOC M, V284, pE531, DOI 10.1152/ajpendo.00299.2002
   Yin M, 1999, GASTROENTEROLOGY, V117, P942, DOI 10.1016/S0016-5085(99)70354-9
   Younossi ZM, 2001, AM J GASTROENTEROL, V96, P2199, DOI 10.1016/S0002-9270(01)02519-9
   ZAMMIT VA, 1984, PROG LIPID RES, V23, P39, DOI 10.1016/0163-7827(84)90005-5
NR 101
TC 86
Z9 103
U1 0
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-8329
EI 1873-6823
J9 ALCOHOL
JI Alcohol
PD AUG
PY 2004
VL 34
IS 1
BP 67
EP 79
DI 10.1016/j.alcohol.2004.07.007
PG 13
WC Substance Abuse; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Substance Abuse; Pharmacology & Pharmacy; Toxicology
GA 898KB
UT WOS:000227074600011
PM 15670668
DA 2025-06-11
ER

PT J
AU Mohammadi, A
   Sahebkar, A
   Kermani, T
   Zhilaee, M
   Tavallaie, S
   Mobarhan, MG
AF Mohammadi, Akram
   Sahebkar, Amirhossein
   Kermani, Tayyebeh
   Zhilaee, Marzieh
   Tavallaie, Shima
   Mobarhan, Majid Ghayour
TI Barberry Administration and Pro-Oxidant-Antioxidant Balance in Patients
   With Metabolic Syndrome
SO IRANIAN RED CRESCENT MEDICAL JOURNAL
LA English
DT Article
DE Metabolic Cardiovascular Syndrome; Berberidaceae; Randomized Controlled
   Trial
ID CORONARY-ARTERY-DISEASE; BERBERIS-VULGARIS L.; OXIDATIVE STRESS
AB Background: Metabolic syndrome is the constellation of several cardiometabolic risk factors, and is associated with a heightened risk of coronary heart disease (CHD). The pro-oxidant-antioxidant balance (PAB) is a measure of factors that promote and control oxidative stress. PAB may also be associated with the risk factors of CHD.
   Objectives: This study aimed to explore the impact of supplementation with barberry, a fruit rich in antioxidants, on PAB in patients with metabolic syndrome.
   Patients and Methods: A total of 106 patients diagnosed with metabolic syndrome were randomized in two groups: case and control. The case group received three capsules of barberry and the control group received three capsules of placebo for 6 weeks. Serum PAB was measured in all patients before and after the intervention.
   Results: There was no significant difference between the groups regarding their baseline PAB values (P = 0.32). A significant decrease in PAB was observed in the barberry group (P = 0.022), whilst there was no significant change in the control group (P = 0.18). The magnitude of change in PAB during the study was significantly greater in the case group compared to the control group (P = 0.01).
   Conclusions: Barberry supplementation reduces oxidative burden in patients with metabolic syndrome.
C1 [Mohammadi, Akram; Sahebkar, Amirhossein; Kermani, Tayyebeh; Zhilaee, Marzieh; Tavallaie, Shima; Mobarhan, Majid Ghayour] Mashhad Univ Med Sci, Biochem Nutr Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences
RP Mobarhan, MG (corresponding author), Mashhad Univ Med Sci, Biochem Nutr Res Ctr, Mashhad, Iran.
EM ghayourm@mums.ac.ir
RI Sahebkar, Amirhossein/B-5124-2018; kermani, tayyebe/M-1171-2017;
   Ghayour-Mobarhan, Majid/AAY-5963-2020
FU Research Council at Mashhad University of Medical Sciences, Mashhad,
   Iran
FX This work was financially supported by the Research Council at Mashhad
   University of Medical Sciences, Mashhad, Iran.
CR Alamdari DH, 2008, CLIN BIOCHEM, V41, P375, DOI 10.1016/j.clinbiochem.2007.12.008
   Alamdari DH, 2007, CLIN BIOCHEM, V40, P248, DOI 10.1016/j.clinbiochem.2006.10.017
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   [Anonymous], 2011, PHARM ONLINE, DOI DOI 10.1016/J.CLINBIOCHEM.2011.08.825
   Ashok BT, 1999, EXP GERONTOL, V34, P293, DOI 10.1016/S0531-5565(99)00005-4
   Cheng F, 2013, INT J CARDIOL, V167, P936, DOI 10.1016/j.ijcard.2012.03.090
   Choi DS, 2001, BIOSCI BIOTECH BIOCH, V65, P452, DOI 10.1271/bbb.65.452
   CHOI DW, 1990, ANNU REV NEUROSCI, V13, P171, DOI 10.1146/annurev.ne.13.030190.001131
   Gale EAM, 2008, BRIT MED J, V336, P640, DOI [10.1136/bmj.39477.500197.AD, 10.1136/bmj.39484.636586.94]
   Ghayour-Mobarhan M, 2009, ANGIOLOGY, V60, P657, DOI 10.1177/0003319709333868
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Gundogdu M., 2013, Advances in Environmental Biology, V7, P344
   Hayden MR, 2004, NUTR J, V3, DOI 10.1186/1475-2891-3-4
   Jang MH, 2009, ARCH PHARM RES, V32, P341, DOI 10.1007/s12272-009-1305-z
   Koncic MZ, 2010, FOOD CHEM TOXICOL, V48, P2176, DOI 10.1016/j.fct.2010.05.025
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Liu WH, 2008, CHINESE MED J-PEKING, V121, P706, DOI 10.1097/00029330-200804020-00009
   Luo AX, 2011, J MED PLANTS RES, V5, P3702
   Parizadeh SMR, 2011, LIPIDS, V46, P333, DOI 10.1007/s11745-010-3517-x
   Parzadeh MR, 2011, CLIN LAB, V57, P183
   Potdar D, 2012, FITOTERAPIA, V83, P817, DOI 10.1016/j.fitote.2012.04.012
   Sahebkar A, 2013, PHYTOTHER RES, V27, P1883, DOI 10.1002/ptr.4952
   Sahebkar A, 2011, CLIN BIOCHEM, V44, P1390, DOI 10.1016/j.clinbiochem.2011.09.011
   Shirwaikar A, 2006, BIOL PHARM BULL, V29, P1906, DOI 10.1248/bpb.29.1906
   Surveswaran S, 2007, FOOD CHEM, V102, P938, DOI 10.1016/j.foodchem.2006.06.033
   Tara F, 2010, J PERINAT MED, V38, P473, DOI [10.1515/JPM.2010.068, 10.1515/jpm.2010.068]
   Yao J, 2013, SCI CHINA LIFE SCI
   Yazdanpanah MJ, 2011, INT J DERMATOL, V50, P1343, DOI 10.1111/j.1365-4632.2011.04968.x
   Yokozawa T, 2004, J PHARM PHARMACOL, V56, P547, DOI 10.1211/0022357023024
   Zhou JY, 2011, FITOTERAPIA, V82, P184, DOI 10.1016/j.fitote.2010.08.019
NR 30
TC 14
Z9 14
U1 0
U2 4
PU KOWSAR PUBL
PI HOENSBROEK
PA PATERSWEG 22,, HOENSBROEK, LIMBURG 6431 GC, NETHERLANDS
SN 2074-1804
EI 2074-1812
J9 IRAN RED CRESCENT ME
JI Iran. Red Crescent Med. J.
PD DEC
PY 2014
VL 16
IS 12
AR e16786
DI 10.5812/ircmj.16786
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AX8OE
UT WOS:000347167800007
PM 25763235
OA Green Submitted, Bronze, Green Published
DA 2025-06-11
ER

PT J
AU da Silva, LEM
   Costa, PRD
   Magalhaes, KBBD
   Cunha, CD
   Alves, WPD
   Pereira, EM
   de Santana, MLP
AF da Silva, Lais Eloy Machado
   Costa, Priscila Ribas de Farias
   Magalhaes, Karine Brito Beck da Silva
   Cunha, Carla de Magalhaes
   Alves, Wilanne Pinheiro de Oliveira
   Pereira, Emile Miranda
   de Santana, Monica Leila Portela
TI Dietary Pattern and Depressive Outcomes in Children and Adolescents:
   Systematic Review and Meta-analysis of Observational Studies
SO NUTRITION REVIEWS
LA English
DT Review; Early Access
DE dietary pattern; depression; adolescents; meta-analysis
ID MENTAL-HEALTH PROBLEMS; CARDIOMETABOLIC RISK; OXIDATIVE STRESS;
   ASSOCIATION; SYMPTOMS; QUALITY; ANXIETY; ADHERENCE; LIFE; ADULTS
AB Context Research suggests that dietary pattern plays an important role in mental health and constitutes a modifiable risk factor for depression.Objective The aim of this systematic review and meta-analysis was to evaluate the association between dietary patterns and depressive outcomes in adolescents.Data Sources Medline/PubMed, Lilacs, EMBASE, PsycINFO, and PsycARTICLES, gray literature up to March 2024 were searched; the reference lists were also verified. Observational studies in participants with a mean age <= 19 years reporting associations between dietary patterns and clinical depression or depressive symptoms were searched. Overall, 21 studies were included in this systematic review.Data Extraction Data from eligible articles were extracted by 2 reviewers.Data Analysis Odds ratios (ORs) and confidence intervals (CIs) were determined under a random-effects model. The risk of bias assessment was conducted by 2 independent researchers using the Joanna Briggs Institute Critical Appraisal Checklist tool.Results The qualitative results revealed that a higher unhealthy diet score was positively associated with depressive symptoms, while a healthy diet was negatively associated with depressive symptoms. In the study that included adolescents with a clinical diagnosis of depression, the relationship between inflammatory dietary pattern tertiles and depression was attenuated after all covariates were adjusted for. The meta-analysis to evaluate the association between depressive symptoms and a posteriori dietary patterns found that the "healthy" dietary pattern decreased depressive symptoms in adolescents (OR: 0.69; 95% CI: 0.44, 0.95). There was no statistically significant association between depressive symptoms and "unhealthy" and "snacks" patterns (OR: 1.20 [95% CI: 0.95, 1.46]; OR: 1.20 [95% CI: 0.70, 1.48]) dietary patterns.Conclusion The results identified that a healthy dietary pattern decreased depressive symptoms in adolescents. However, considering the high heterogeneity and the low level of certainty of the evidence, these results should be interpreted with caution.Systematic Review Registration PROSPERO registration no. CRD42020159921.
C1 [da Silva, Lais Eloy Machado; Alves, Wilanne Pinheiro de Oliveira; Pereira, Emile Miranda] Univ Fed Bahia, Food Nutr & Hlth Postgrad Program, Araujo Pinho Ave,32, BR-40110150 Salvador, BA, Brazil.
   [Costa, Priscila Ribas de Farias; Magalhaes, Karine Brito Beck da Silva; Cunha, Carla de Magalhaes; de Santana, Monica Leila Portela] Univ Fed Bahia, Sci Nutr Dept, BR-40110150 Salvador, BA, Brazil.
C3 Universidade Federal da Bahia; Universidade Federal da Bahia
RP da Silva, LEM (corresponding author), Univ Fed Bahia, Food Nutr & Hlth Postgrad Program, Araujo Pinho Ave,32, BR-40110150 Salvador, BA, Brazil.
EM laieloy@hotmail.com
RI DE FARIAS COSTA, PRISCILA/AIB-6441-2022; Cunha, Carla/ABB-5382-2021
OI CUNHA, CARLA/0000-0002-9644-7194
FU Coordenao de Aperfeioamento de Pessoal de Nvel Superior-Brasil; FAPESB
   (Foundation for Research Support in Bahia)
FX The authors thank the FAPESB (Foundation for Research Support in Bahia)
   for providing a scholarship to this study.
CR Akseer N, 2017, ANN NY ACAD SCI, V1393, P3, DOI 10.1111/nyas.13336
   Alves MD, 2019, CAD SAUDE PUBLICA, V35, DOI 10.1590/0102-311X00153818
   American Psychiatric Association (APA), 2013, Diagnostic and Statistical Manual of Mental Disorders, V5th ed
   Ang AL, 2019, PEDIATR INT, V61, P404, DOI 10.1111/ped.13778
   Anisman H, 2009, J PSYCHIATR NEUROSCI, V34, P4
   Beigrezaei S, 2023, BMC PSYCHIATRY, V23, DOI 10.1186/s12888-023-05313-7
   Black CN, 2015, PSYCHONEUROENDOCRINO, V51, P164, DOI 10.1016/j.psyneuen.2014.09.025
   Cong X, 2020, BRAIN BEHAV IMMUN-HL, V2, DOI 10.1016/j.bbih.2019.100017
   Cunha CD, 2018, BRIT J NUTR, V119, P859, DOI 10.1017/S0007114518000533
   Darabi Z, 2024, NUTR J, V23, DOI 10.1186/s12937-024-00913-9
   Das JK, 2017, ANN NY ACAD SCI, V1393, P21, DOI 10.1111/nyas.13330
   Erskine HE, 2017, EPIDEMIOL PSYCH SCI, V26, P395, DOI 10.1017/S2045796015001158
   Gianfredi V, 2023, NUTR REV, V81, P346, DOI 10.1093/nutrit/nuac058
   Gimeno D, 2009, PSYCHOL MED, V39, P413, DOI 10.1017/S0033291708003723
   Hayward J, 2016, AUST NZ J PSYCHIAT, V50, P1064, DOI 10.1177/0004867416671596
   Hebestreit A, 2017, NUTRIENTS, V9, DOI 10.3390/nu9020126
   Hemmati A, 2021, CLIN NUTR ESPEN, V46, P271, DOI 10.1016/j.clnesp.2021.09.743
   Higgins JPT, 2003, BMJ-BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557
   Hu FB, 2002, CURR OPIN LIPIDOL, V13, P3, DOI 10.1097/00041433-200202000-00002
   Jacka FN, 2013, SOC PSYCH PSYCH EPID, V48, P1297, DOI 10.1007/s00127-012-0623-5
   Jacka FN, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024805
   Jacka FN, 2010, AUST NZ J PSYCHIAT, V44, P435, DOI 10.3109/00048670903571598
   Jacka FN, 2009, AUST NZ J PSYCHIAT, V43, P45, DOI 10.1080/00048670802534408
   Jiménez-López E, 2024, EUR CHILD ADOLES PSY, V33, P2637, DOI 10.1007/s00787-023-02351-0
   Khalid S, 2016, BRIT J NUTR, V116, P2097, DOI 10.1017/S0007114516004359
   Khayyatzadeh SS, 2019, PSYCHIAT RES, V272, P467, DOI 10.1016/j.psychres.2018.12.164
   Khayyatzadeh SS, 2018, PSYCHIAT RES, V259, P104, DOI 10.1016/j.psychres.2017.09.075
   Khosravi M, 2020, INT J VITAM NUTR RES, V90, P417, DOI 10.1024/0300-9831/a000586
   Lai JS, 2014, AM J CLIN NUTR, V99, P181, DOI 10.3945/ajcn.113.069880
   Li ZY, 2019, MED SCI MONITOR, V25, P7459, DOI 10.12659/MSM.916774
   Liao YH, 2019, TRANSL PSYCHIAT, V9, DOI 10.1038/s41398-019-0515-5
   Liu MW, 2020, J AFFECT DISORDERS, V261, P172, DOI 10.1016/j.jad.2019.10.007
   Lucas M, 2014, BRAIN BEHAV IMMUN, V36, P46, DOI 10.1016/j.bbi.2013.09.014
   Matos SMA, 2012, NUTR HOSP, V27, P1114, DOI 10.3305/nh.2012.27.4.5883
   Fernández-Alvira JM, 2015, BRIT J NUTR, V113, P517, DOI 10.1017/S0007114514003663
   Ministerio da Saude, 2014, Diretrizes metodologicas: Sistema GRADE-Manual de graduacao da qualidade da evidencia e forca de recomendacao para tomada de decisao em saude
   Moola S., 2017, Checklist for Analytical Cross Sectional Studies
   Moola S., 2017, CHECKLIST COHORT STU
   Myint AM, 2003, MED HYPOTHESES, V61, P519, DOI 10.1016/S0306-9877(03)00207-X
   Neshatbinitehrani A., 2016, Iranian Journal of Nutrition Sciences & Food Technology, V11, P9
   Nguyen PH, 2009, ARCH LATINOAM NUTR, V59, P278
   Northstone K, 2013, BRIT J NUTR, V109, P2050, DOI 10.1017/S0007114512004072
   O'Neil A, 2014, AM J PUBLIC HEALTH, V104, pE31, DOI 10.2105/AJPH.2014.302110
   Oddy WH, 2018, BRAIN BEHAV IMMUN, V69, P428, DOI 10.1016/j.bbi.2018.01.002
   Orlando L, 2022, AUST NZ J PSYCHIAT, V56, P617, DOI 10.1177/00048674211031486
   Ouzzani M, 2016, SYST REV-LONDON, V5, DOI 10.1186/s13643-016-0384-4
   Page MJ, 2021, BMJ-BRIT MED J, V372, DOI [10.1136/bmj.n71, 10.1136/bmj.n160]
   Patterson SL, 2015, NEUROPHARMACOLOGY, V96, P11, DOI 10.1016/j.neuropharm.2014.12.020
   Probst Y, 2015, NUTRIENTS, V7, P6128, DOI 10.3390/nu7085274
   Qian KJ, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1180858
   Quirk SE, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-175
   Rahe C, 2014, EUR J NUTR, V53, P997, DOI 10.1007/s00394-014-0652-9
   Rashidkhani B, 2013, PSYCHIAT RES, V210, P115, DOI 10.1016/j.psychres.2013.05.022
   Rhie SJ, 2020, J EXERC REHABIL, V16, P2, DOI 10.12965/jer.2040016.008
   Rocha NP, 2017, J PEDIAT-BRAZIL, V93, P214, DOI 10.1016/j.jped.2017.01.002
   Rubio-López N, 2016, INT J ENV RES PUB HE, V13, DOI 10.3390/ijerph13030352
   Sánchez-Villegas A, 2009, J HUM NUTR DIET, V22, P122, DOI 10.1111/j.1365-277X.2008.00931.x
   Sánchez-Villegas A, 2011, NUTR NEUROSCI, V14, P195, DOI 10.1179/1476830511Y.0000000011
   Sánchez-Villegas A, 2009, ARCH GEN PSYCHIAT, V66, P1090, DOI 10.1001/archgenpsychiatry.2009.129
   Sangouni AA, 2022, BIOPSYCHOSOC MED, V16, DOI 10.1186/s13030-022-00234-5
   Sarandol A, 2007, HUM PSYCHOPHARM CLIN, V22, P67, DOI 10.1002/hup.829
   Scaglioni S, 2018, NUTRIENTS, V10, DOI 10.3390/nu10060706
   Shivappa N, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00400
   Sinclair R, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0161709
   Stradling Clare, 2014, Cardiovascular & Hematological Disorders - Drug Targets, V14, P50
   Stroup DF, 2000, JAMA-J AM MED ASSOC, V283, P2008, DOI 10.1001/jama.283.15.2008
   Suzumura ER., Diretrizes metodologicas: elaboracao de revisao sistematica e metanalise de ensaios clinicos randomizados
   Tehrani AN, 2018, MEDITERR J NUTR META, V11, P73, DOI 10.3233/MNM-17192
   Vancampfort D, 2018, INT J BEHAV NUTR PHY, V15, DOI 10.1186/s12966-018-0708-y
   Vejrup K, 2023, NUTRIENTS, V15, DOI 10.3390/nu15010243
   Wartberg L, 2018, DTSCH ARZTEBL INT, V115, P549, DOI 10.3238/arztebl.2018.0549
   Weng TT, 2012, PUBLIC HEALTH NUTR, V15, P673, DOI 10.1017/S1368980011003077
   Winpenny EM, 2018, PUBLIC HEALTH NUTR, V21, P2376, DOI 10.1017/S1368980018001179
   World Health Organization, 2017, WHOMSDMER20172
   Xie XY, 2024, J AFFECT DISORDERS, V350, P550, DOI 10.1016/j.jad.2024.01.101
   Zhang ER, 2024, J AFFECT DISORDERS, V352, P110, DOI 10.1016/j.jad.2024.02.032
   Zohrabi T, 2022, BMC PEDIATR, V22, DOI 10.1186/s12887-022-03589-4
   Zurita-Ortega F, 2018, NUTRIENTS, V10, DOI 10.3390/nu10080966
NR 78
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD 2025 APR 15
PY 2025
DI 10.1093/nutrit/nuae182
EA APR 2025
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1JX5Z
UT WOS:001466788500001
PM 40233215
DA 2025-06-11
ER

PT J
AU Bilu, C
   Einat, H
   Barak, O
   Zimmet, P
   Vishnevskia-Dai, V
   Govrin, A
   Agam, G
   Kronfeld-Schor, N
AF Bilu, Carmel
   Einat, Haim
   Barak, Orly
   Zimmet, Paul
   Vishnevskia-Dai, Vicktoria
   Govrin, Amanda
   Agam, Galila
   Kronfeld-Schor, Noga
TI Linking type 2 diabetes mellitus, cardiac hypertrophy and depression in
   a diurnal animal model
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ANXIETY-LIKE BEHAVIORS; FAT SAND RAT; METABOLIC SYNDROME; CIRCADIAN
   CLOCK; CARDIOVASCULAR-DISEASE; COMORBID DEPRESSION; INSULIN-RESISTANCE;
   ACTIVITY RHYTHMS; SHORT DAYLIGHT; RODENTS
AB It was recently suggested that the Metabolic Syndrome should be renamed to "Circadian Syndrome". In this context, we explored the effects of living under standard laboratory conditions, where light is the only cycling variable (relevant to human modern life), in a diurnal mammal, on the relationships between affective-like pathology, type 2 diabetes mellitus (T2DM), and cardiac hypertrophy. After 20 weeks, some of the animals spontaneously developed T2DM, depressive and anxiety-like behavior and cardiac hypertrophy. There were significant correlations between levels of anxiety-like behavior and glucose tolerance, and between heart/total body weight ratio and glucose tolerance. Our data suggest a relationship between the development of T2DM, emotional and cardiac pathology as seen in diurnal humans. Furthermore, our data show a possible relationship between reduced daily cycling cues in the laboratory and what has been regularly termed "Metabolic Syndrome" and recently proposed by us to be renamed to "Circadian Syndrome".
C1 [Bilu, Carmel; Barak, Orly; Govrin, Amanda; Kronfeld-Schor, Noga] Tel Aviv Univ, Sch Zool, Ramat Aviv, Israel.
   [Bilu, Carmel; Einat, Haim; Agam, Galila] Ben Gurion Univ Negev, Dept Clin Biochem & Pharmacol, Beer Sheva, Israel.
   [Einat, Haim] Tel Aviv Yaffo Acad Coll, Sch Behav Sci, Tel Aviv, Israel.
   [Zimmet, Paul] Monash Univ, Cent Clin Sch, Dept Diabet, Melbourne, Vic, Australia.
   [Vishnevskia-Dai, Vicktoria] Tel Aviv Univ, Sackler Fac Med, Cha Sheba Med Ctr, Ocular Oncol & Autoimmune Serv,Goldschleger Eye I, Tel Aviv, Israel.
C3 Tel Aviv University; Ben-Gurion University of the Negev; Monash
   University; Tel Aviv University; Sackler Faculty of Medicine
RP Kronfeld-Schor, N (corresponding author), Tel Aviv Univ, Sch Zool, Ramat Aviv, Israel.
EM nogaks@tauex.tau.ac.il
RI Einat, Haim/AAZ-9746-2020; Zimmet, Paul/H-7635-2013; Kronfeld-Schor,
   Noga/AAU-3792-2020
OI Kronfeld-Schor, Noga/0000-0002-5224-3341
FU Israel Science Foundation [866/17]
FX This research was supported by the Israel Science Foundation (grant No.
   866/17).
CR Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   Ashkenazy T, 2009, BEHAV BRAIN RES, V201, P343, DOI 10.1016/j.bbr.2009.03.005
   Ashkenazy T, 2009, INT J NEUROPSYCHOPH, V12, P83, DOI 10.1017/S1461145708009115
   Barak O, 2013, CHRONOBIOL INT, V30, P1123, DOI 10.3109/07420528.2013.805337
   BARNETT M, 1994, INT J OBESITY, V18, P789
   Belzung C, 2001, BEHAV BRAIN RES, V125, P141, DOI 10.1016/S0166-4328(01)00291-1
   Bilu C., 2019, CHRONOBIOL INT, V15, P1
   Bilu C, 2019, CHRONOBIOL INT, V36, P919, DOI 10.1080/07420528.2019.1595638
   Bilu C, 2019, J BIOL RHYTHM, V34, P69, DOI 10.1177/0748730418819373
   Bilu C, 2016, DRUG DEVELOP RES, V77, P336, DOI 10.1002/ddr.21346
   Bilu C, 2013, CHRONOBIOL INT, V30, P828, DOI 10.3109/07420528.2013.773439
   BIRD RE, 1983, SOL ENERGY, V30, P563, DOI 10.1016/0038-092X(83)90068-3
   Blanchong JA, 1999, J BIOL RHYTHM, V14, P364, DOI 10.1177/074873099129000777
   Chaudhary R, 2018, CURR ATHEROSCLER REP, V20, DOI 10.1007/s11883-018-0746-6
   Cheung BMY, 2012, CURR ATHEROSCLER REP, V14, P160, DOI 10.1007/s11883-012-0227-2
   Cohen R, 2006, PHYSIOL BEHAV, V87, P563, DOI 10.1016/j.physbeh.2005.12.010
   Crnko S, 2019, NAT REV CARDIOL, V16, P437, DOI 10.1038/s41569-019-0167-4
   Daan S, 2011, J BIOL RHYTHM, V26, P118, DOI 10.1177/0748730410397645
   Dominoni DM, 2016, BIOL LETTERS, V12, DOI 10.1098/rsbl.2016.0015
   Durgan DJ, 2010, CIRC RES, V106, P647, DOI 10.1161/CIRCRESAHA.109.209957
   Edgar N, 2013, BIOESSAYS, V35, P940, DOI 10.1002/bies.201300086
   Egede LE, 2005, DIABETES CARE, V28, P1339, DOI 10.2337/diacare.28.6.1339
   Egede LE, 2002, DIABETES CARE, V25, P464, DOI 10.2337/diacare.25.3.464
   Einat H, 2006, BEHAV BRAIN RES, V173, P153, DOI 10.1016/j.bbr.2006.06.006
   Flaisher-Grinberg S, 2011, BEHAV PHARMACOL, V22, P23, DOI 10.1097/FBP.0b013e3283425012
   Gluckman PD, 2009, NAT REV ENDOCRINOL, V5, P401, DOI 10.1038/nrendo.2009.102
   Graham N, 2016, J HYPERTENS, V34, P397, DOI 10.1097/HJH.0000000000000850
   Gramaglia C, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00621
   Hagenauer MH, 2008, BIOL RHYTHM RES, V39, P269, DOI 10.1080/09291010701683425
   Haim A, 2006, J THERM BIOL, V31, P168, DOI 10.1016/j.jtherbio.2005.11.016
   HAINES H, 1965, AM J PHYSIOL, V208, P297, DOI 10.1152/ajplegacy.1965.208.2.297
   Holt RIG, 2014, CURR DIABETES REP, V14, DOI 10.1007/s11892-014-0491-3
   Javeed N, 2018, PHYSIOLOGY, V33, P138, DOI 10.1152/physiol.00003.2018
   Kaiser Nurit, 2012, Methods Mol Biol, V933, P89, DOI 10.1007/978-1-62703-068-7_7
   KALDERON B, 1986, DIABETES, V35, P717, DOI 10.2337/diabetes.35.6.717
   Kalman R, 2012, AM COLL LAB, P1171, DOI 10.1016/B978-0-12-380920-9.00054-7
   Kalsbeek A, 2011, FEBS LETT, V585, P1412, DOI 10.1016/j.febslet.2011.03.021
   KANETY H, 1994, P NATL ACAD SCI USA, V91, P1853, DOI 10.1073/pnas.91.5.1853
   Krivisky K, 2012, J NEURAL TRANSM, V119, P1241, DOI 10.1007/s00702-012-0783-1
   Krivisky K, 2011, NEUROPSYCHOBIOLOGY, V63, P191, DOI 10.1159/000321805
   Kronfeld-Schor N, 2008, BIOL RHYTHM RES, V39, P193, DOI 10.1080/09291010701683268
   Li Min-Dian, 2012, Yale Journal of Biology and Medicine, V85, P387
   Li ZZ, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000001317
   MARQUIE G, 1984, DIABETES, V33, P438, DOI 10.2337/diabetes.33.5.438
   McIntyre Roger S, 2007, Ann Clin Psychiatry, V19, P257, DOI 10.1080/10401230701653377
   Mendelssohn H., 1999, Fauna Palestina: Mammalia of Israel
   Neeman E., 1999, NATURAL LIGHT BUILDI
   Noordam R., 2019, J CLIN ENDOCRINOLOGY
   Ouyang JQ, 2018, J EXP BIOL, V221, DOI 10.1242/jeb.156893
   PANDA S, 2019, NATURE REVIEWS ENDOC, V1, DOI DOI 10.1145/3314493.3314505
   Park M, 2013, GEN HOSP PSYCHIAT, V35, P217, DOI 10.1016/j.genhosppsych.2013.01.006
   PELLOW S, 1985, J NEUROSCI METH, V14, P149, DOI 10.1016/0165-0270(85)90031-7
   Petrie JR, 2018, CAN J CARDIOL, V34, P575, DOI 10.1016/j.cjca.2017.12.005
   Poggiogalle E, 2018, METABOLISM, V84, P11, DOI 10.1016/j.metabol.2017.11.017
   Prasai MJ, 2008, DIABETES VASC DIS RE, V5, P89, DOI 10.3132/dvdr.2008.015
   Qian J, 2018, SLEEP, V41, pA17, DOI 10.1093/sleep/zsy061.040
   Qian JY, 2016, TRENDS ENDOCRIN MET, V27, P282, DOI 10.1016/j.tem.2016.03.005
   Renn BN, 2011, CLIN PSYCHOL REV, V31, P1239, DOI 10.1016/j.cpr.2011.08.001
   Robillard R, 2018, TRANSL PSYCHIAT, V8, DOI 10.1038/s41398-018-0255-y
   Rüger M, 2009, REV ENDOCR METAB DIS, V10, P245, DOI 10.1007/s11154-009-9122-8
   SCHMIDTNIELSEN K, 1964, SCIENCE, V143, P689, DOI 10.1126/science.143.3607.689
   Shafrir Eleazar, 1993, Journal of Basic and Clinical Physiology and Pharmacology, V4, P83
   Shaw E, 2009, CURR ATHEROSCLER REP, V11, P289, DOI 10.1007/s11883-009-0044-4
   Sowers JR, 2001, HYPERTENSION, V37, P1053, DOI 10.1161/01.HYP.37.4.1053
   Staels B, 2006, NAT MED, V12, P54, DOI 10.1038/nm0106-54
   Stenvers DJ, 2019, NAT REV ENDOCRINOL, V15, P75, DOI 10.1038/s41574-018-0122-1
   Stevenson TJ, 2015, P ROY SOC B-BIOL SCI, V282, DOI 10.1098/rspb.2015.1453
   Stukalin Y, 2017, PHARM BIOCH BEHAV, V28, P30408
   Tal-Krivisky K, 2015, PHYSIOL BEHAV, V151, P441, DOI 10.1016/j.physbeh.2015.08.002
   Thosar SS, 2018, J CLIN INVEST, V128, P2157, DOI 10.1172/JCI80590
   Tomotani BM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0037918
   Touati H, 2018, BRAIN RES, V1679, P116, DOI 10.1016/j.brainres.2017.11.018
   Umezu T, 1989, Yakubutsu Seishin Kodo, V9, P369
   van der Vinne V, 2015, J EXP BIOL, V218, P2585, DOI 10.1242/jeb.119354
   Van Laake LW, 2018, EUR HEART J, V39, P2326, DOI 10.1093/eurheartj/ehx775
   Versteeg RI, 2016, P NUTR SOC, V75, P451, DOI 10.1017/S0029665116000707
   Walder K R, 2000, Int J Exp Diabetes Res, V1, P177, DOI 10.1155/EDR.2000.177
   West AC, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00462-2
   Wirz-Justice A, 2006, INT CLIN PSYCHOPHARM, V21, pS11, DOI 10.1097/01.yic.0000195660.37267.cf
   Yaffe K, 2007, ALZ DIS ASSOC DIS, V21, P167, DOI 10.1097/WAD.0b013e318065bfd6
   Zimmet P, 2019, J INTERN MED, V286, P181, DOI 10.1111/joim.12924
   Zimmet P, 1999, ANN NY ACAD SCI, V892, P25, DOI 10.1111/j.1749-6632.1999.tb07783.x
   Zimmet PZ, 2014, LANCET DIABETES ENDO, V2, P56, DOI 10.1016/S2213-8587(13)70112-8
NR 83
TC 15
Z9 15
U1 0
U2 8
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 14
PY 2019
VL 9
AR 11865
DI 10.1038/s41598-019-48326-7
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA IQ3UW
UT WOS:000480678100064
PM 31413352
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rosson, S
   Monaco, F
   Miola, A
   Cascino, G
   Stubbs, B
   Correll, CU
   Firth, J
   Ermis, C
   Perrotti, A
   Marciello, F
   Carvalho, AF
   Brunoni, AR
   Fusar-Poli, P
   Fornaro, M
   Gentile, G
   Granziol, U
   Pigato, G
   Favaro, A
   Solmi, M
AF Rosson, Stella
   Monaco, Francesco
   Miola, Alessandro
   Cascino, Giammarco
   Stubbs, Brendon
   Correll, Christoph U.
   Firth, Joseph
   Ermis, Cagatay
   Perrotti, Andrea
   Marciello, Francesca
   Carvalho, Andre F.
   Brunoni, Andre R.
   Fusar-Poli, Paolo
   Fornaro, Michele
   Gentile, Giovanni
   Granziol, Umberto
   Pigato, Giorgio
   Favaro, Angela
   Solmi, Marco
TI Longitudinal Course of Depressive, Anxiety, and Posttraumatic Stress
   Disorder Symptoms After Heart Surgery: A Meta-Analysis of 94 Studies
SO PSYCHOSOMATIC MEDICINE
LA English
DT Review
DE depression; anxiety; cardiovascular diseases; heart surgery;
   posttraumatic stress disorder; CABG = coronary artery bypass graft; CHD
   = coronary heart disease; CI = confidence interval; CVD = cardiovascular
   disease; HF = heart failure; HS = heart surgery; HT = heart
   transplantation; ICD = implantable cardioverter-defibrillator; MetS =
   metabolic syndrome; NOS = Newcastle-Ottawa Scale; PTSD = posttraumatic
   stress disorder; PTSS = posttraumatic stress symptoms; VAD = ventricular
   assist device
ID QUALITY-OF-LIFE; CARDIAC-SURGERY; DISEASE; RISK; MORTALITY; OUTCOMES;
   IMPACT
AB Objective
   This study aimed to analyze the longitudinal course of depression, anxiety, and posttraumatic stress disorder (PTSD) symptoms in patients with cardiac disease after heart surgery (HS). Methods
   We conducted a systematic review and random-effects meta-analysis of cohort studies in patients undergoing HS, measuring anxiety, depressive, and PTSD symptoms before and at least 30 days thereafter. Subgroup and meta-regression analyses, investigation of publication bias, and quality assessment were undertaken. Results
   We included 94 studies relating to 15,561 patients. HS included coronary artery bypass graft surgery, valve replacement, implantable cardioverter-defibrillator placement, left ventricular assist device placement, heart transplantation, and other types of HS. Across studies, symptoms of depression (g = 0.32; 95% confidence interval [CI] = 0.25 to 0.39; p < .001) and anxiety improved after HS (g = 0.52; 95% CI = 0.43 to 0.62; p < .001), whereas PTSD symptoms worsened (g = -0.42; 95% CI = -0.80 to -0.04; p = .032). The reduction of depression and anxiety levels was more pronounced for patients with underlying coronary artery disease and heart failure and persisted for 1 year after HS, whereas the increase in PTSD symptoms returned to baseline after 6 months. Depression improvement was inversely associated with older age, diabetes, hypertension, and dyslipidemia and positively with baseline heart failure. No additional clinical or demographic variables were associated with the course of anxiety symptoms. Quality of included studies was low overall. Publication bias was nonsignificant. Conclusions
   Depressive and anxiety symptoms improve for 1 year after HS, whereas PTSD symptoms might worsen. Older patients and those with metabolic comorbidities, valve disease, or ventricular arrhythmias are at higher risk for continued depressive and anxiety symptoms and should be monitored closely.
C1 [Rosson, Stella; Miola, Alessandro; Gentile, Giovanni; Favaro, Angela; Solmi, Marco] Univ Padua, Dept Neurosci, Via Giustiniani 5, I-35100 Padua, Italy.
   [Monaco, Francesco] ASL Salerno, Dept Mental Hlth, Residential Eating Disorder Unit Mariconda, Salerno, Italy.
   [Cascino, Giammarco; Marciello, Francesca] Univ Salerno, Dept Med Surg & Dent, Scuola Med Salernitana, Sect Neurosci, Salerno, Italy.
   [Stubbs, Brendon] South London & Maudsley Natl Hlth Serv Fdn Trust, Physiotherapy Dept, London, England.
   [Stubbs, Brendon] Kings Coll London, Dept Psychol Med, Inst Psychiat Psychol & Neurosci, London, England.
   [Correll, Christoph U.] Northwell Hlth, Dept Psychiat, Zucker Hillside Hosp, Glen Oaks, NY USA.
   [Correll, Christoph U.] Zucker Sch Med Hofstra Northwell, Dept Psychiat & Mol Med, Hempstead, NY USA.
   [Correll, Christoph U.] Feinstein Inst Med Res, Ctr Psychiat Neurosci, Manhasset, NY USA.
   [Correll, Christoph U.] Charite Univ Med Berlin, Dept Child & Adolescent Psychiat, Berlin, Germany.
   [Firth, Joseph] Univ Manchester, Div Psychol & Mental Hlth, Fac Biol Med & Hlth, Manchester, Lancs, England.
   [Firth, Joseph] Univ Western Sydney, NICM Hlth Res Inst, Sch Sci & Hlth, Sydney, NSW, Australia.
   [Firth, Joseph] Univ Melbourne, Ctr Youth Mental Hlth, Melbourne, Vic, Australia.
   [Ermis, Cagatay] Dokuz Eylul Univ, Dept Child & Adolescent Psychiat, Izmir, Turkey.
   [Perrotti, Andrea] Univ Hosp Jean Minjoz, Dept Cardiothorac Surg, Besancon, France.
   [Perrotti, Andrea] Univ Franche Comte, EA 3920, Besancon, France.
   [Carvalho, Andre F.] Univ Toronto, Ctr Addict & Mental Hlth CAMH, Toronto, ON, Canada.
   [Carvalho, Andre F.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Brunoni, Andre R.] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany.
   [Brunoni, Andre R.] Univ Sao Paulo, Serv Interdisciplinary Neuromodulat, Dept Psychiat, Lab Neurosci LIM 27, Sao Paulo, Brazil.
   [Brunoni, Andre R.] Univ Sao Paulo, Natl Inst Biomarkers Neuropsychiat INBioN, Inst Psychiat, Sao Paulo, Brazil.
   [Brunoni, Andre R.] Univ Sao Paulo, Fac Med, Univ Hosp, Dept Clin Med, Sao Paulo, Brazil.
   [Fusar-Poli, Paolo; Solmi, Marco] Kings Coll London, Early Psychosis Intervent & Clin Detect EPIC Lab, Dept Psychosis Studies, Inst Psychiat Psychol & Neurosci, London, England.
   [Fusar-Poli, Paolo] South London & Maudsley NHS Fdn Trust, OASIS Serv, London, England.
   [Fusar-Poli, Paolo] Univ Pavia, Dept Brain & Behav Sci, Pavia, Italy.
   [Fusar-Poli, Paolo] South London & Maudsley NHS Fdn Trust, Natl Inst Hlth Res, Maudsley Biomed Res Ctr, London, England.
   [Fornaro, Michele] Univ Sch Med Federico II, Neurosci Reprod Sci & Odontostolmatol, Sect Psychiat, Naples, Italy.
   [Favaro, Angela; Solmi, Marco] Univ Padua, Ctr Neurosci, Padua, Italy.
   [Granziol, Umberto] Univ Padua, Dept Gen Psychol, Padua, Italy.
   [Pigato, Giorgio] Padua Univ Hosp, Psychiat Unit, Padua, Italy.
C3 University of Padua; University of Salerno; South London & Maudsley NHS
   Trust; University of London; King's College London; Northwell Health;
   Northwell Health; Northwell Health; Berlin Institute of Health; Free
   University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; University of Manchester; Western Sydney
   University; University of Melbourne; Orygen, The National Centre of
   Excellence in Youth Mental Health; Dokuz Eylul University; Universite de
   Franche-Comte; CHU Besancon; Universite de Franche-Comte; University of
   Toronto; Centre for Addiction & Mental Health - Canada; University of
   Toronto; University of Munich; Universidade de Sao Paulo; Universidade
   de Sao Paulo; Universidade de Sao Paulo; University of London; King's
   College London; South London & Maudsley NHS Trust; University of Pavia;
   South London & Maudsley NHS Trust; University of Naples Federico II;
   University of Padua; University of Padua; University of Padua; Azienda
   Ospedaliera - Universita di Padova
RP Rosson, S (corresponding author), Univ Padua, Dept Neurosci, Via Giustiniani 5, I-35100 Padua, Italy.; Rosson, S (corresponding author), Univ Padua, Dept Neurosci, Via Giustiniani 5, I-35100 Padua, Italy.
EM stella.rosson@gmail.com; fmonaco1980@gmail.com; ale.mio90@hotmail.it;
   gcascino14@gmail.com; brendon.stubbs@kcl.ac.uk; CCorrell@northwell.edu;
   joefirth@gmail.com; ermiscagatay@gmail.com; a.perrotti@hotmail.it;
   francescamarciello81@gmail.com; Andre.Carvalho@camh.ca;
   brunowsky@gmail.com; paolo.fusar-poli@kcl.ac.uk; dott.fornaro@gmail.com;
   giovanni.gentile@unipd.it; umberto.granziol@phd.unipd.it;
   giorgio.pigato@aopd.veneto.it; angela.favaro@unipd.it;
   Marco.solmi83@gmail.com
RI Cascino, Giammarco/HWQ-4669-2023; Carvalho, Andre/AEZ-4001-2022;
   GRANZIOL, UMBERTO/ISB-5815-2023; solmi, marco/K-3906-2018; Miola,
   Alessandro/LMP-0749-2024; Gentile, Giovanni/AAY-3281-2021; Correll,
   Christoph/D-3530-2011; Firth, Joseph/JOZ-1679-2023; Stubbs,
   Brendon/X-1904-2018; Russowsky Brunoni, Andre/H-8394-2012; Stubbs,
   Brendon/C-5696-2015; Fusar-Poli, Paolo/D-8605-2011; Favaro,
   Angela/J-2966-2012; Monaco, Francesco/ADD-7161-2022
OI Russowsky Brunoni, Andre/0000-0002-6310-3571; solmi,
   marco/0000-0003-4877-7233; Stubbs, Brendon/0000-0001-7387-3791; Cascino,
   Giammarco/0000-0003-0358-8594; Fusar-Poli, Paolo/0000-0003-3582-6788;
   Gentile, Giovanni/0000-0001-6393-2655; Favaro,
   Angela/0000-0002-6540-5194; Rosson, Stella/0000-0002-8554-3519; Monaco,
   Francesco/0000-0002-1854-292X; Correll, Christoph U/0000-0002-7254-5646
FU Janssen; Takeda; Scientific and Technological Research Council of Turkey
   (TUBITAK); University of Manchester Presidential Fellowship [P123958];
   UK Research and Innovation Future Leaders Fellowship [MR/T021780/1];
   Lundbeck
FX S.R., F.Mo., A.M., G.C., B.S., A.P., F. Ma., A.F.C., A. R.B., M.F.,
   G.G., U.G., G.P., and A.F. have no conflict of interest to declare.
   C.U.C. has been a consultant and/or advisor to or has received honoraria
   from the following: Alkermes, Allergan, Angelini, Gedeon Richter, Gerson
   Lehrman Group, IntraCellular Therapies, Janssen/J&J, LB Pharma,
   Lundbeck, MedAvante-ProPhase, Medscape, Neurocrine, Noven, Otsuka,
   Pfizer, Recordati, Rovi, Sumitomo Dainippon, Sunovion, Supernus, Takeda,
   and Teva. He has provided expert testimony for Janssen and Otsuka. He
   served on a Data Safety Monitoring Board for Lundbeck, Rovi, Supernus,
   and Teva. He received royalties from UpToDate and grant support from
   Janssen and Takeda. He is also a stock option holder of LB Pharma. C.E.
   was supported by a grant from The Scientific and Technological Research
   Council of Turkey (TUBITAK). J.F. is supported by a University of
   Manchester Presidential Fellowship (P123958) and a UK Research and
   Innovation Future Leaders Fellowship (MR/T021780/1). P.F.-P. has
   received honoraria from Lundbeck and Menarini and grant support from
   Lundbeck. M.S. received honoraria as consultant/advisor in advisory
   boards and/or for talks/presentations from Angelini and Lundbeck. This
   research received no specific grant from any funding agency, or
   commercial or not-for-profit sectors.
CR Al-Bitar ZB, 2017, EUR J ORTHODONT, V39, P92, DOI 10.1093/ejo/cjw029
   Alraies MC, 2014, J THORAC DIS, V6, P1120, DOI 10.3978/j.issn.2072-1439.2014.06.44
   American Psychiatric Association, 2013, Diagnostic and Statistical Manual of Mental Disorders: DSM-IV, DOI [DOI 10.1176/APPI.BOOKS.9780890425596, 10.1176/appi.books.9780890425596]
   [Anonymous], Comprehensive Meta-Analysis (Version 2.0)
   Association AP, 2013, Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
   BEGG CB, 1994, BIOMETRICS, V50, P1088, DOI 10.2307/2533446
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   D'Agostino RS, 2017, ANN THORAC SURG, V103, P18, DOI 10.1016/j.athoracsur.2016.11.001
   DERSIMONIAN R, 1986, CONTROL CLIN TRIALS, V7, P177, DOI 10.1016/0197-2456(86)90046-2
   DerSimonian R, 2007, CONTEMP CLIN TRIALS, V28, P105, DOI 10.1016/j.cct.2006.04.004
   Egger M, 1997, BMJ-BRIT MED J, V315, P629, DOI 10.1136/bmj.315.7109.629
   Feola M, 2013, OPEN CARDIOVASC MED, V7, P54, DOI 10.2174/1874192401307010054
   Firth J, 2019, LANCET PSYCHIAT, V6, P675, DOI 10.1016/S2215-0366(19)30132-4
   Frasure-Smith N, 2008, ARCH GEN PSYCHIAT, V65, P62, DOI 10.1001/archgenpsychiatry.2007.4
   Furtado M, 2015, PSYCHIAT RES, V229, P37, DOI 10.1016/j.psychres.2015.05.036
   Fusar-Poli P, 2005, J HEART LUNG TRANSPL, V24, P2269, DOI 10.1016/j.healun.2005.06.022
   Fusar-Poli P, 2006, J HEART LUNG TRANSPL, V25, P785, DOI 10.1016/j.healun.2006.03.019
   Ghoneim MM, 2016, BMC SURG, V16, DOI 10.1186/s12893-016-0120-y
   Hata M, 2006, CIRC J, V70, P389, DOI 10.1253/circj.70.389
   He YK, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000016287
   Higgins JPT, 2003, BMJ-BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557
   Hillebrand S, 2013, EUROPACE, V15, P742, DOI 10.1093/europace/eus341
   Hu MX, 2016, PSYCHOSOM MED, V78, P562, DOI 10.1097/PSY.0000000000000313
   Huffman Jeff C, 2013, Cardiovasc Psychiatry Neurol, V2013, P695925, DOI 10.1155/2013/695925
   Joseph JJ, 2017, ANN NY ACAD SCI, V1391, P20, DOI 10.1111/nyas.13217
   Lane-Fall Meghan B, 2019, Anesthesiol Clin, V37, P135, DOI 10.1016/j.anclin.2018.09.012
   Lossnitzer N, 2020, DEPRESS ANXIETY, V37, P898, DOI 10.1002/da.23041
   Lyngso J, 2017, CLIN EPIDEMIOL, V9, P699, DOI 10.2147/CLEP.S146496
   Martinelli V, 2007, J HEART LUNG TRANSPL, V26, P544, DOI 10.1016/j.healun.2007.01.023
   Meentken MG, 2017, FRONT PEDIATR, V5, DOI 10.3389/fped.2017.00020
   Meng L, 2012, J HYPERTENS, V30, P842, DOI 10.1097/HJH.0b013e32835080b7
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Moulton CD, 2015, LANCET DIABETES ENDO, V3, P461, DOI 10.1016/S2213-8587(15)00134-5
   Nasser M, 2020, AM J PUBLIC HEALTH, V110, P753, DOI 10.2105/AJPH.2020.305609
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Parekh A, 2017, HEALTHCARE-BASEL, V5, DOI 10.3390/healthcare5010005
   Pignay-Demaria V, 2003, ANN THORAC SURG, V75, P314, DOI 10.1016/S0003-4975(02)04391-6
   Politi P, 2004, TRANSPLANTATION, V78, P257, DOI 10.1097/01.tp.0000133537.87951.f2
   Porhomayon J, 2014, J CARDIOVASC THORAC, V6, P79, DOI 10.5681/jcvtr.2014.018
   Roest AM, 2010, J AM COLL CARDIOL, V56, P38, DOI 10.1016/j.jacc.2010.03.034
   Roy T, 2012, J AFFECT DISORDERS, V142, pS8, DOI 10.1016/S0165-0327(12)70004-6
   Santiago PN, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059236
   Schelling Gustav, 2008, Prog Brain Res, V167, P229
   Stuckey MI, 2014, DIABETES-METAB RES, V30, P784, DOI 10.1002/dmrr.2555
   Takagi H, 2017, HEART VESSELS, V32, P1458, DOI 10.1007/s00380-017-1022-3
   Tang F, 2017, PSYCHONEUROENDOCRINO, V77, P112, DOI 10.1016/j.psyneuen.2016.11.025
   Tully PJ, 2014, J PSYCHOSOM RES, V77, P439, DOI 10.1016/j.jpsychores.2014.10.001
   Tully PJ, 2012, J GERIATR CARDIOL, V9, P197, DOI 10.3724/SP.J.1263.2011.12221
   Vilchinsky N, 2017, CLIN PSYCHOL REV, V55, P92, DOI 10.1016/j.cpr.2017.04.009
   Wells GA., 2014, The Newcastle -Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta -analyses, DOI DOI 10.1007/S10654-010-9491-Z
NR 50
TC 16
Z9 16
U1 1
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JAN
PY 2021
VL 83
IS 1
BP 85
EP 93
DI 10.1097/PSY.0000000000000872
PG 9
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA QE8SS
UT WOS:000616476000009
PM 33021524
OA Green Published
DA 2025-06-11
ER

PT J
AU Blanchard, MS
   Eisen, SA
   Alpern, R
   Karlinsky, J
   Toomey, R
   Reda, DJ
   Murphy, FM
   Jackson, LW
   Kang, HK
AF Blanchard, MS
   Eisen, SA
   Alpern, R
   Karlinsky, J
   Toomey, R
   Reda, DJ
   Murphy, FM
   Jackson, LW
   Kang, HK
TI Chronic multisymptom illness complex in Gulf War I veterans 10 years
   later
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE Gulf War; metabolic syndrome X; Persian Gulf syndrome; quality of life;
   risk factors; stress; psychological; veterans
ID NEUROMUSCULAR SYMPTOMS; RISK-FACTORS; HEALTH; ASSOCIATION; DISORDERS;
   MORTALITY; SERVICE; STRESS
AB Prior research has demonstrated that shortly after the 1991 Gulf War (Gulf War I), chronic multisymptom illness (CMI) was more common among deployed veterans than among nondeployed veterans. The aims of the current study were to determine the prevalence of CMI among deployed and nondeployed veterans 10 years after Gulf War I, compare the distribution of comorbid conditions, and identify prewar factors associated with CMI. Cross-sectional data collected from 1,061 deployed veterans and 1,128 nondeployed veterans examined between 1999 and 2001 were analyzed. CMI prevalence was 28.9% among deployed veterans and 15.8% among nondeployed veterans (odds ratio = 2.16, 95% confidence interval: 1.61, 2.90). Deployed and nondeployed veterans with CMI had similarly poorer quality-of-life measures and higher prevalences of symptom-based medical conditions, metabolic syndrome, and psychiatric disorders. Diagnoses of prewar anxiety disorders (not related to post-traumatic stress disorder) and depression were associated with CMI among both deployed and nondeployed veterans. Nicotine dependence and veteran-reported physician-diagnosed infectious mononucleosis were associated with CMI among deployed veterans, and migraine headaches and gastritis were associated with CMI among nondeployed veterans. CMI continues to be substantially more prevalent among deployed veterans than among nondeployed veterans 10 years after Gulf War I, but it manifests similarly in both groups. It is likely to be a common, persistent problem among veterans returning from the current Gulf War.
C1 St Louis Vet Affairs Med Ctr, Med Serv, St Louis, MO 63106 USA.
   St Louis Vet Affairs Med Ctr, Res Serv, St Louis, MO 63106 USA.
   Washington Univ, Sch Med, Dept Internal Med, St Louis, MO 63110 USA.
   US Dept Vet Affairs, Vet Affairs Edward Hines Jr Hosp, Cooperat Studies Program Coordinating Ctr, Hines, IL 60141 USA.
   VA Boston Healthcare Syst, Boston, MA USA.
   Boston Univ, Sch Med, Dept Med, Div Pulm & Crit Care Med, W Roxbury, MA USA.
   Harvard Univ, Sch Med, Dept Psychiat, Massachusetts Mental Hlth Ctr, Boston, MA 02115 USA.
   Harvard Univ, Sch Publ Hlth, Inst Psychiat Epidemiol & Genet, Boston, MA 02115 USA.
   Harvard Univ, Sch Med, Boston, MA 02115 USA.
   Dept Vet Affairs, Cent Off, Washington, DC USA.
   Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
   Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA.
   Dept Vet Affairs, Environm Epidemiol Serv, Washington, DC USA.
   George Washington Univ, Sch Publ Hlth & Hlth Serv, Washington, DC USA.
C3 Washington University (WUSTL); US Department of Veterans Affairs;
   Veterans Health Administration (VHA); Edward Hines Jr. VA Hospital;
   Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; Boston University; Harvard University; Harvard
   Medical School; Harvard University; Harvard T.H. Chan School of Public
   Health; Harvard University; Harvard Medical School; Uniformed Services
   University of the Health Sciences - USA; Johns Hopkins University; Johns
   Hopkins Bloomberg School of Public Health; George Washington University
RP St Louis Vet Affairs Med Ctr, Med Serv, 111-JC,915 N Grand Ave, St Louis, MO 63106 USA.
EM melvin.blanchard@med.va.gov
RI kang, han/KIC-4795-2024
OI Eisen, Seth/0000-0001-7746-6624; , Domenic/0000-0003-1831-4270
CR Aaron LA, 2001, ANN INTERN MED, V134, P868, DOI 10.7326/0003-4819-134-9_Part_2-200105011-00011
   Amato AA, 1997, NEUROLOGY, V48, P4, DOI 10.1212/WNL.48.1.4
   Andrews G, 1998, SOC PSYCH PSYCH EPID, V33, P80, DOI 10.1007/s001270050026
   [Anonymous], 1995, Arch Intern Med, V155, P262
   Baker DG, 2001, MIL MED, V166, P972, DOI 10.1093/milmed/166.11.972
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   Clauw DJ, 2002, AM J IND MED, V41, P370, DOI 10.1002/ajim.10068
   Coker WJ, 1999, BMJ-BRIT MED J, V318, P290, DOI 10.1136/bmj.318.7179.290
   Davis LE, 2004, NEUROLOGY, V63, P1070, DOI 10.1212/01.WNL.0000138426.88460.CB
   Donta ST, 2004, ANN INTERN MED, V141, P85, DOI 10.7326/0003-4819-141-2-200407200-00006
   Donta ST, 2003, JAMA-J AM MED ASSOC, V289, P1396, DOI 10.1001/jama.289.11.1396
   Dunphy RC, 2003, PAIN, V102, P79, DOI 10.1016/S0304-3959(02)00342-1
   Eisen SA, 2005, ANN INTERN MED, V142, P881, DOI 10.7326/0003-4819-142-11-200506070-00005
   Fukuda K, 1998, JAMA-J AM MED ASSOC, V280, P981, DOI 10.1001/jama.280.11.981
   Gray GC, 1999, AM J TROP MED HYG, V60, P752, DOI 10.4269/ajtmh.1999.60.752
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Haley RN, 2004, AM J MED, V117, P469, DOI 10.1016/j.amjmed.2004.03.041
   Haley RW, 1997, JAMA-J AM MED ASSOC, V277, P231, DOI 10.1001/jama.277.3.231
   Hoge CW, 2002, AM J PSYCHIAT, V159, P1576, DOI 10.1176/appi.ajp.159.9.1576
   Hotopf M, 2003, BRIT MED J, V327, P1370, DOI 10.1136/bmj.327.7428.1370
   Jousilahti P, 1996, CIRCULATION, V93, P1372, DOI 10.1161/01.CIR.93.7.1372
   Kang HK, 2000, J OCCUP ENVIRON MED, V42, P491, DOI 10.1097/00043764-200005000-00006
   Kipen HM, 1999, ARCH ENVIRON HEALTH, V54, P313, DOI 10.1080/00039899909602493
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lo SC, 2000, EPIDEMIOL INFECT, V125, P609, DOI 10.1017/S0950268800004891
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   Mense S, 2000, SCAND J RHEUMATOL, V29, P24, DOI 10.1080/030097400446599
   Mittal VA, 2011, PSYCHIAT RES, V189, P158, DOI 10.1016/j.psychres.2011.06.006
   Nisenbaum R, 2000, J NERV MENT DIS, V188, P259, DOI 10.1097/00005053-200005000-00002
   Proctor SP, 1998, INT J EPIDEMIOL, V27, P1000, DOI 10.1093/ije/27.6.1000
   *RES TRIANGL I, 2001, SUDAAN REL 8 0
   ROBINSON A, 1995, CAN MED ASSOC J, V152, P944
   Schwartz DA, 1997, JAMA-J AM MED ASSOC, V277, P238, DOI 10.1001/jama.277.3.238
   Sharief MK, 2002, NEUROLOGY, V59, P1518, DOI 10.1212/01.WNL.0000032755.27372.FC
   Steele L, 2000, AM J EPIDEMIOL, V152, P992, DOI 10.1093/aje/152.10.992
   Stuart JA, 2002, MIL MED, V167, P121, DOI 10.1093/milmed/167.2.121
   Unwin C, 1999, LANCET, V353, P169, DOI 10.1016/S0140-6736(98)11338-7
   Ware J. E., 1994, SF-36 physical and mental summary scales: A users manual
   Ware JE., 2000, The SF-36 Health Survey: Manual and Interpretation Guide
   White PD, 2001, LANCET, V358, P1946, DOI 10.1016/S0140-6736(01)06961-6
   White RF, 2001, AM J IND MED, V40, P42, DOI 10.1002/ajim.1070
   Whooley MA, 2002, ARCH INTERN MED, V162, P2614, DOI 10.1001/archinte.162.22.2614
   Winkenwerder W., 2002, US DEMOLITION OPERAT
   Wolfe J, 1998, AM J IND MED, V33, P104, DOI 10.1002/(SICI)1097-0274(199802)33:2<104::AID-AJIM2>3.0.CO;2-Y
   Wolfe J, 2002, J OCCUP ENVIRON MED, V44, P271, DOI 10.1097/00043764-200203000-00015
   1995, MMWR, V44, P443
NR 46
TC 102
Z9 108
U1 0
U2 8
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JAN 1
PY 2006
VL 163
IS 1
BP 66
EP 75
DI 10.1093/aje/kwj008
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 997CS
UT WOS:000234223200008
PM 16293719
OA Bronze
DA 2025-06-11
ER

PT J
AU Tang, ZY
   Zhen, YP
   Zhang, L
   Liu, XB
   Ma, J
AF Tang, Zhongyu
   Zhen, Yanping
   Zhang, Lin
   Liu, Xuebing
   Ma, Jun
TI Prevalence and factors associated with metabolic syndrome in first
   hospitalization for major depression disorder patients
SO SCIENTIFIC REPORTS
LA English
DT Article
ID THYROID-FUNCTION; BIPOLAR DISORDER; RISK; SYMPTOMS; LIFE; SCHIZOPHRENIA;
   COMPONENTS; ANXIETY
AB Major depressive disorder (MDD) is a common and socially burdensome psychiatric disorder with a causal and complex relationship with metabolic syndrome (MetS), which is often co-morbid. However, the prevalence and risk factors for MetS in patients with MDD are inconclusive. The purpose of this study is to investigate the prevalence and factors influencing MetS in first hospitalization MDD patients. A total of 981 MDD patients were included. Sociodemographic and general clinical data were collected from the patients, while metabolism-related parameters were also measured, and psychological symptoms were assessed. Our study found that the prevalence of MetS in the study population was 9.68%. MDD patients with MetS had higher levels of metabolism-related parameters and more severe psychological symptoms. We identified risk factors for MetS and its severity separately: age of onset of MDD, more severe depressive symptoms, and higher thyroid stimulating hormone (TSH) levels were risk factors for the development of MetS, whereas higher TSH levels were risk factors for the severity of MetS. Our results suggest that MetS is not highly prevalent in MDD patients, but certain risk factors may increase its likelihood and severity, and that these findings could be beneficial for clinical intervention and care of MetS.
C1 [Tang, Zhongyu; Zhang, Lin; Liu, Xuebing; Ma, Jun] Wuhan Mental Hlth Ctr, Dept Psychiat, 89 Gongnongbing Rd, Wuhan, Hubei, Peoples R China.
   [Tang, Zhongyu; Zhang, Lin; Liu, Xuebing; Ma, Jun] Wuhan Hosp Psychotherapy, Wuhan, Peoples R China.
   [Zhen, Yanping] Hubei Univ Sci & Technol, Affiliated Hosp 2, Dept Psychiat, Xianning, Peoples R China.
C3 Hubei University of Science & Technology
RP Liu, XB; Ma, J (corresponding author), Wuhan Mental Hlth Ctr, Dept Psychiat, 89 Gongnongbing Rd, Wuhan, Hubei, Peoples R China.; Liu, XB; Ma, J (corresponding author), Wuhan Hosp Psychotherapy, Wuhan, Peoples R China.
EM 107768791@qq.com; majun0313@msn.cn
RI Ma, Jun/HLV-7600-2023
FU scientific research project of Wuhan Municipal Health Commission
   [WG20D12]
FX We are grateful to all the medical staffs and patients in our study and
   to those who contributed to the diagnosis and clinical evaluation of the
   subjects. This study was funded by the scientific research project of
   Wuhan Municipal Health Commission (WG20D12, Zhongyu Tang, PI).
CR Amouzegar A, 2018, THYROID, V28, P458, DOI 10.1089/thy.2017.0454
   Bayturan O, 2010, ARCH INTERN MED, V170, P478, DOI 10.1001/archinternmed.2009.551
   Butnoriene J, 2014, PSYCHONEUROENDOCRINO, V40, P269, DOI 10.1016/j.psyneuen.2013.11.002
   Chang CH, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-07004-2
   Crichton GE, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-3170-2
   Godin O, 2019, J CLIN PSYCHIAT, V80, DOI 10.4088/JCP.19m12755
   Grover S, 2017, ASIAN J PSYCHIATR, V27, P139, DOI 10.1016/j.ajp.2017.02.030
   Gurka MJ, 2016, PSYCHONEUROENDOCRINO, V68, P82, DOI 10.1016/j.psyneuen.2016.02.030
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Huang YC, 2022, WORLD J BIOL PSYCHIA, V23, P483, DOI 10.1080/15622975.2021.2013091
   Hussain S, 2018, PSYCHIAT RES, V270, P264, DOI 10.1016/j.psychres.2018.09.037
   Kahl KG, 2012, EUR ARCH PSY CLIN N, V262, P313, DOI 10.1007/s00406-011-0277-4
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Kessler RC, 2013, ANNU REV PUBL HEALTH, V34, P119, DOI 10.1146/annurev-publhealth-031912-114409
   Kessler RC, 2012, INT J METH PSYCH RES, V21, P169, DOI 10.1002/mpr.1359
   Kim HB, 2023, J AFFECT DISORDERS, V323, P46, DOI 10.1016/j.jad.2022.11.049
   Laclaustra M, 2019, DIABETES CARE, V42, P303, DOI 10.2337/dc18-1410
   Laursen TM, 2016, J AFFECT DISORDERS, V193, P203, DOI 10.1016/j.jad.2015.12.067
   Li ZZ, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000001317
   Liu D, 2021, PROG NEURO-PSYCHOPH, V111, DOI 10.1016/j.pnpbp.2021.110339
   Ljubicic R, 2013, COLLEGIUM ANTROPOL, V37, P1065
   Lucidi L, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22073723
   Ma YJ, 2019, BMC PSYCHIATRY, V19, DOI 10.1186/s12888-019-2131-6
   Marano G, 2023, NUTRIENTS, V15, DOI 10.3390/nu15061496
   Mehran L, 2017, HORM METAB RES, V49, P192, DOI 10.1055/s-0042-117279
   Monroe SM, 2022, ANNU REV CLIN PSYCHO, V18, P329, DOI 10.1146/annurev-clinpsy-072220-021440
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Park SB, 2011, J KOREAN MED SCI, V26, P540, DOI 10.3346/jkms.2011.26.4.540
   Peng P, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1138233
   Perez CSDH, 2022, J AFFECT DISORDERS, V298, P95, DOI 10.1016/j.jad.2021.10.038
   de Melo LGP, 2017, PROG NEURO-PSYCHOPH, V78, P34, DOI 10.1016/j.pnpbp.2017.04.027
   Postolache TT, 2019, AM J MED GENET B, V180, P186, DOI 10.1002/ajmg.b.32712
   Pyykkönen AJ, 2012, ANN MED, V44, P279, DOI 10.3109/07853890.2010.543921
   Rhee SJ, 2014, PROG NEURO-PSYCHOPH, V54, P223, DOI 10.1016/j.pnpbp.2014.06.006
   Samson SL, 2014, ENDOCRIN METAB CLIN, V43, P1, DOI 10.1016/j.ecl.2013.09.009
   Silarova B, 2015, J PSYCHOSOM RES, V78, P391, DOI 10.1016/j.jpsychores.2015.02.010
   Smith TW, 2017, ANN BEHAV MED, V51, P610, DOI 10.1007/s12160-017-9883-3
   Takeuchi T, 2013, PSYCHIAT CLIN NEUROS, V67, P532, DOI 10.1111/pcn.12104
   Teixeira PDD, 2020, THER ADV ENDOCRINOL, V11, DOI 10.1177/2042018820917869
   Thomas ML, 2018, CANCERS, V10, DOI 10.3390/cancers10040101
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Wu MY, 2022, EUR J CLIN INVEST, V52, DOI 10.1111/eci.13646
   Yao F, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124475
   Zeng K, 2023, ANN GEN PSYCHIATR, V22, DOI 10.1186/s12991-023-00455-0
   Zhang RY, 2022, FRONT PUBLIC HEALTH, V9, DOI 10.3389/fpubh.2021.797183
   Zhao K, 2020, BMC PSYCHIATRY, V20, DOI 10.1186/s12888-020-02791-x
NR 47
TC 3
Z9 3
U1 0
U2 5
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 19
PY 2023
VL 13
IS 1
AR 15496
DI 10.1038/s41598-023-42720-y
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA W1ES9
UT WOS:001089134700054
PM 37726320
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Cubbon, RM
   Kahn, MB
   Wheatcroft, SB
AF Cubbon, Richard M.
   Kahn, Matthew B.
   Wheatcroft, Stephen B.
TI Effects of insulin resistance on endothelial progenitor cells and
   vascular repair
SO CLINICAL SCIENCE
LA English
DT Review
DE cardiometabolic risk; endothelial progenitor cell (EPC); insulin
   resistance; obesity; metabolic syndrome; Type 2 diabetes
ID NITRIC-OXIDE SYNTHASE; COLONY-STIMULATING FACTOR; ACUTE
   MYOCARDIAL-INFARCTION; CORONARY-ARTERY-DISEASE; BONE-MARROW-CELLS;
   GROWTH-FACTOR-I; PERIPHERAL-BLOOD; METABOLIC-SYNDROME;
   DIABETES-MELLITUS; GLUCOSE-TOLERANCE
AB Insulin resistance, a key feature of obesity, the metabolic syndrome and Type 2 diabetes mellitus, results in an array of metabolic and vascular phenomena which ultimately promote the development of atherosclerosis. Endothelial dysfunction is intricately related to insulin resistance through the parallel stimulatory effects of insulin on glucose disposal in metabolic tissues and NO production in the endothelium. Perturbations characteristic of insulin resistance, including dyslipidaemia, inflammation and oxidative stress, may jeopardize the structural or functional integrity of the endothelium. Recent evidence suggests that endothelial damage is mitigated by endogenous reparative processes which mediate endothelial regeneration. EPCs (endothelial progenitor cells) are circulating cells which have been identified as mediators of endothelial repair. Several of the abnormalities associated with insulin resistance, including reduced NO bioavailability, increased production of ROS (reactive oxygen species) and down-regulation of intracellular signalling pathways, have the potential to disrupt EPC function. Improvement in the number and function of EPCs may contribute to the protective actions of evidence-based therapies to reduce cardiometabolic risk. In the present article, we review the putative effects of insulin resistance on EPCs, discuss the underlying mechanisms and highlight potential therapeutic manoeuvres which could improve vascular repair in individuals with insulin resistance.
C1 [Wheatcroft, Stephen B.] Univ Leeds, Div Cardiovasc & Diabet Res, LIGHT, Leeds LS2 9JT, W Yorkshire, England.
   Univ Leeds, Multidisciplinary Cardiovasc Res Ctr, Leeds LS2 9JT, W Yorkshire, England.
C3 University of Leeds; University of Leeds
RP Wheatcroft, SB (corresponding author), Univ Leeds, Div Cardiovasc & Diabet Res, LIGHT, Leeds LS2 9JT, W Yorkshire, England.
EM s.b.wheatcroft@leeds.ac.uk
FU British Heart Foundation; Diabetes UK
FX The authors' work is supported by the British Heart Foundation and
   Diabetes UK.
CR Ackah E, 2005, J CLIN INVEST, V115, P2119, DOI 10.1172/JCI24726
   Aicher A, 2005, HYPERTENSION, V45, P321, DOI 10.1161/01.HYP.0000154789.28695.ea
   Aicher A, 2004, TRENDS MOL MED, V10, P421, DOI 10.1016/j.molmed.2004.07.007
   Aicher A, 2003, NAT MED, V9, P1370, DOI 10.1038/nm948
   Aicher A, 2007, CIRC RES, V100, P581, DOI 10.1161/01.RES.0000259562.63718.35
   Andreou I, 2006, ATHEROSCLEROSIS, V189, P247, DOI 10.1016/j.atherosclerosis.2006.06.021
   Asahara T, 1999, CIRC RES, V85, P221, DOI 10.1161/01.RES.85.3.221
   Asahara T, 1999, EMBO J, V18, P3964, DOI 10.1093/emboj/18.14.3964
   Asai K, 2000, ARTERIOSCL THROM VAS, V20, P1493, DOI 10.1161/01.ATV.20.6.1493
   Assmus B, 2002, CIRCULATION, V106, P3009, DOI 10.1161/01.CIR.0000043246.74879.CD
   Assmus B, 2006, NEW ENGL J MED, V355, P1222, DOI 10.1056/NEJMoa051779
   Awad O, 2005, STEM CELLS, V23, P575, DOI 10.1634/stemcells.2004-0185
   Badillo AT, 2007, J SURG RES, V143, P35, DOI 10.1016/j.jss.2007.03.051
   Bahlmann FH, 2005, HYPERTENSION, V45, P526, DOI 10.1161/01.HYP.0000159191.98140.89
   Balletshofer BM, 2000, CIRCULATION, V101, P1780, DOI 10.1161/01.CIR.101.15.1780
   Bauersachs J, 2007, EUR J CLIN INVEST, V37, P603, DOI 10.1111/j.1365-2362.2007.01833.x
   Baumgartl J, 2006, CELL METAB, V3, P247, DOI 10.1016/j.cmet.2006.02.010
   Benboubker L, 2001, BRIT J HAEMATOL, V113, P247, DOI 10.1046/j.1365-2141.2001.02717.x
   Berg AH, 2002, TRENDS ENDOCRIN MET, V13, P84, DOI 10.1016/S1043-2760(01)00524-0
   Bhagat K, 1997, CIRCULATION, V96, P3042, DOI 10.1161/01.CIR.96.9.3042
   Bjornholm M, 1997, DIABETES, V46, P524, DOI 10.2337/diabetes.46.3.524
   Booth GL, 2006, LANCET, V368, P29, DOI 10.1016/S0140-6736(06)68967-8
   Burke GL, 2008, ARCH INTERN MED, V168, P928, DOI 10.1001/archinte.168.9.928
   Busija DW, 2006, ANTIOXID REDOX SIGN, V8, P1131, DOI 10.1089/ars.2006.8.1131
   Caballero AE, 1999, DIABETES, V48, P1856, DOI 10.2337/diabetes.48.9.1856
   Ceradini DJ, 2008, J BIOL CHEM, V283, P10930, DOI 10.1074/jbc.M707451200
   Ceradini DJ, 2004, NAT MED, V10, P858, DOI 10.1038/nm1075
   Chen H, 2003, J BIOL CHEM, V278, P45021, DOI 10.1074/jbc.M307878200
   Chen M, 2007, HYPERTENS RES, V30, P971, DOI 10.1291/hypres.30.971
   Chen YH, 2007, DIABETES, V56, P1559, DOI 10.2337/db06-1103
   Cubbon RM, 2007, EUR HEART J, V28, P540, DOI 10.1093/eurheartj/ehl510
   Cusi K, 2000, J CLIN INVEST, V105, P311, DOI 10.1172/JCI7535
   Dimmeler S, 2004, J MOL MED, V82, P671, DOI 10.1007/s00109-004-0580-x
   Dimmeler S, 2001, J CLIN INVEST, V108, P391, DOI 10.1172/JCI13152
   Dormandy JA, 2005, LANCET, V366, P1279, DOI 10.1016/S0140-6736(05)67528-9
   Duckworth W, 2009, NEW ENGL J MED, V360, P129, DOI 10.1056/NEJMoa0808431
   Duncan ER, 2007, AM J PHYSIOL-ENDOC M, V293, pE1311, DOI 10.1152/ajpendo.00299.2007
   Duncan ER, 2008, DIABETES, V57, P3307, DOI 10.2337/db07-1111
   Egan CG, 2008, DIABETOLOGIA, V51, P1296, DOI 10.1007/s00125-008-0939-6
   Ellger B, 2008, ENDOCRINOLOGY, V149, P3148, DOI 10.1210/en.2007-1558
   Erdmann E, 2007, J AM COLL CARDIOL, V49, P1772, DOI 10.1016/j.jacc.2006.12.048
   Eringa EC, 2004, AM J PHYSIOL-HEART C, V287, pH2043, DOI 10.1152/ajpheart.00067.2004
   Fadini GP, 2007, DIABETOLOGIA, V50, P2156, DOI 10.1007/s00125-007-0732-y
   Fadini GP, 2006, DIABETOLOGIA, V49, P3075, DOI 10.1007/s00125-006-0401-6
   Fadini GP, 2008, DIABETES CARE, V31, P808, DOI 10.2337/dc07-1996
   Fadini GP, 2008, ARTERIOSCL THROM VAS, V28, P997, DOI 10.1161/ATVBAHA.107.159558
   Fadini GP, 2006, EUR HEART J, V27, P2247, DOI 10.1093/eurheartj/ehl198
   Fadini GP, 2005, J AM COLL CARDIOL, V45, P1449, DOI 10.1016/j.jacc.2004.11.067
   Fleissner F, 2008, MOL MED, V14, P235, DOI 10.2119/2008-00037.Fleissner
   Fontaine V, 2006, AM J PATHOL, V169, P1855, DOI 10.2353/ajpath.2006.060260
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Foteinos G, 2008, CIRCULATION, V117, P1856, DOI 10.1161/CIRCULATIONAHA.107.746008
   Fox CS, 2004, JAMA-J AM MED ASSOC, V292, P2495, DOI 10.1001/jama.292.20.2495
   Fujishima S, 1998, AM J HYPERTENS, V11, P1134, DOI 10.1016/S0895-7061(98)00130-7
   Galasso G, 2006, CIRC RES, V98, P254, DOI 10.1161/01.RES.0000200740.57764.52
   Gallagher KA, 2007, J CLIN INVEST, V117, P1249, DOI 10.1172/JCI29710
   George J, 2005, ARTERIOSCL THROM VAS, V25, P2636, DOI 10.1161/01.ATV.0000188554.49745.9e
   Gerstein HC, 2008, NEW ENGL J MED, V358, P2545, DOI 10.1056/NEJMoa0802743
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Grundy SM, 2001, CIRCULATION, V104, P491, DOI 10.1161/01.CIR.104.4.491
   Hamdy O, 2003, DIABETES CARE, V26, P2119, DOI 10.2337/diacare.26.7.2119
   Han JK, 2008, CIRCULATION, V118, P1021, DOI 10.1161/CIRCULATIONAHA.108.777169
   Han S, 2006, CELL METAB, V3, P257, DOI 10.1016/j.cmet.2006.02.008
   Harrison DG, 1997, J CLIN INVEST, V100, P2153, DOI 10.1172/JCI119751
   Hill JM, 2005, J AM COLL CARDIOL, V46, P1643, DOI 10.1016/j.jacc.2005.01.067
   Hill JM, 2003, NEW ENGL J MED, V348, P593, DOI 10.1056/NEJMoa022287
   Hirschi KK, 2008, ARTERIOSCL THROM VAS, V28, P1584, DOI 10.1161/ATVBAHA.107.155960
   Holman RR, 2008, NEW ENGL J MED, V359, P1577, DOI 10.1056/NEJMoa0806470
   Hopkins TA, 2007, CARDIOVASC RES, V74, P11, DOI 10.1016/j.cardiores.2006.10.009
   Hristov M, 2003, ARTERIOSCL THROM VAS, V23, P1185, DOI 10.1161/01.ATV.0000073832.49290.B5
   Hsueh WA, 2004, AM J MED, V117, P109, DOI 10.1016/j.amjmed.2004.02.042
   Hsueh WA, 1999, AM J CARDIOL, V84, p21J
   Huang PP, 2005, DIABETES CARE, V28, P2155, DOI 10.2337/diacare.28.9.2155
   Humpert PM, 2008, MOL MED, V14, P301, DOI 10.2119/2007-00052.Humpert
   Humpert PM, 2005, DIABETES CARE, V28, P934, DOI 10.2337/diacare.28.4.934
   Hur J, 2004, ARTERIOSCL THROM VAS, V24, P288, DOI 10.1161/01.ATV.0000114236.77009.06
   IGNARRO LJ, 1987, P NATL ACAD SCI USA, V84, P9265, DOI 10.1073/pnas.84.24.9265
   Ii M, 2006, CIRC RES, V98, P697, DOI 10.1161/01.RES.0000209948.50943.ea
   Imanishi T, 2005, J HYPERTENS, V23, P1699, DOI 10.1097/01.hjh.0000176788.12376.20
   Ingram DA, 2005, BLOOD, V105, P2783, DOI 10.1182/blood-2004-08-3057
   Ingram DA, 2004, BLOOD, V104, P2752, DOI 10.1182/blood-2004-04-1396
   Ingram DA, 2008, DIABETES, V57, P724, DOI 10.2337/db07-1507
   Ishiki M, 2005, ENDOCRINOLOGY, V146, P5071, DOI 10.1210/en.2005-0850
   Iwaguro H, 2002, CIRCULATION, V105, P732, DOI 10.1161/hc0602.103673
   Iwakura A, 2003, CIRCULATION, V108, P3115, DOI 10.1161/01.CIR.0000106906.56972.83
   Janssens S, 2006, LANCET, V367, P113, DOI 10.1016/S0140-6736(05)67861-0
   Jiang ZY, 1999, J CLIN INVEST, V104, P447, DOI 10.1172/JCI5971
   Juul A, 2002, CIRCULATION, V106, P939, DOI 10.1161/01.CIR.0000027563.44593.CC
   KAHN M, 2008, DIABETES VASC DIS RE, V5, P240
   Kalka C, 2000, ANN THORAC SURG, V70, P829, DOI 10.1016/S0003-4975(00)01633-7
   Kalka C, 2000, P NATL ACAD SCI USA, V97, P3422, DOI 10.1073/pnas.070046397
   Kang HJ, 2004, LANCET, V363, P751, DOI 10.1016/S0140-6736(04)15689-4
   Karra R, 2005, P NATL ACAD SCI USA, V102, P16789, DOI 10.1073/pnas.0507718102
   Kawamoto A, 2001, CIRCULATION, V103, P634
   Kearney MT, 2008, EXP PHYSIOL, V93, P158, DOI 10.1113/expphysiol.2007.039172
   Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213
   King GL, 2004, HISTOCHEM CELL BIOL, V122, P333, DOI 10.1007/s00418-004-0678-9
   King H, 1998, DIABETES CARE, V21, P1414, DOI 10.2337/diacare.21.9.1414
   Kusuyama T, 2006, J PHARMACOL SCI, V102, P96, DOI 10.1254/jphs.FP0060256
   Laufs U, 2005, EUR J CARDIOV PREV R, V12, P407, DOI 10.1097/01.hjr.0000174823.87269.2e
   Laufs U, 2004, CIRCULATION, V109, P220, DOI 10.1161/01.CIR.0000109141.48980.37
   Laufs U, 1998, CIRCULATION, V97, P1129, DOI 10.1161/01.CIR.97.12.1129
   Lemieux C, 2009, INT J CARDIOL, V136, P200, DOI 10.1016/j.ijcard.2008.04.054
   LEVIN ER, 1995, NEW ENGL J MED, V333, P356, DOI 10.1056/NEJM199508103330607
   Lunde K, 2006, NEW ENGL J MED, V355, P1199, DOI 10.1056/NEJMoa055706
   Malmberg K, 1997, BRIT MED J, V314, P1512, DOI 10.1136/bmj.314.7093.1512
   Matsuo Y, 2007, CIRC J, V71, P1376, DOI 10.1253/circj.71.1376
   Melikian N, 2008, ATHEROSCLEROSIS, V197, P375, DOI 10.1016/j.atherosclerosis.2007.06.009
   Min TQ, 2004, CARDIOVASC DRUG THER, V18, P203, DOI 10.1023/B:CARD.0000033641.33503.bd
   Momin AU, 2006, EUR HEART J, V27, P2294, DOI 10.1093/eurheartj/ehi831
   Monastyrskaya E, 2002, NITRIC OXIDE-BIOL CH, V7, P127, DOI 10.1016/S1089-8603(02)00107-6
   Montagnani M, 2002, MOL ENDOCRINOL, V16, P1931, DOI 10.1210/me.2002-0074
   Montagnani M, 2001, J BIOL CHEM, V276, P30392, DOI 10.1074/jbc.M103702200
   Müller-Ehmsen J, 2008, EUR HEART J, V29, P1560, DOI 10.1093/eurheartj/ehn213
   Muniyappa R, 1997, LIFE SCI, V61, P925, DOI 10.1016/S0024-3205(97)00594-8
   Murphy C, 2007, ARTERIOSCL THROM VAS, V27, P936, DOI 10.1161/01.ATV.0000258788.11372.d0
   Myers MG, 2008, ANNU REV PHYSIOL, V70, P537, DOI 10.1146/annurev.physiol.70.113006.100707
   Nowak A, 2008, J SPORT MED PHYS FIT, V48, P252
   Ohshima M, 2009, CIRC J, V73, P162, DOI 10.1253/circj.CJ-08-0123
   Patel A, 2008, NEW ENGL J MED, V358, P2560, DOI 10.1056/NEJMoa0802987
   Pistrosch F, 2005, ATHEROSCLEROSIS, V183, P163, DOI 10.1016/j.atherosclerosis.2005.03.039
   Rabelink TJ, 2004, ARTERIOSCL THROM VAS, V24, P834, DOI 10.1161/01.ATV.0000124891.57581.9f
   Rajala MW, 2003, ENDOCRINOLOGY, V144, P3765, DOI 10.1210/en.2003-0580
   Rauscher FM, 2003, CIRCULATION, V108, P457, DOI 10.1161/01.CIR.0000082924.75945.48
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Sandri M, 2005, CIRCULATION, V111, P3391, DOI 10.1161/CIRCULATIONAHA.104.527135
   Sasaki K, 2006, P NATL ACAD SCI USA, V103, P14537, DOI 10.1073/pnas.0604144103
   Schächinger V, 2006, NEW ENGL J MED, V355, P1210, DOI 10.1056/NEJMoa060186
   Schäfer A, 2004, CIRCULATION, V109, P1819, DOI 10.1161/01.CIR.0000126837.88743.DD
   Schmidt TS, 2007, CLIN SCI, V113, P47, DOI 10.1042/CS20070108
   Schroeter MR, 2008, CIRC RES, V103, P536, DOI 10.1161/CIRCRESAHA.107.169375
   Seeger FH, 2005, CIRCULATION, V111, P1184, DOI 10.1161/01.CIR.0000157156.85397.A1
   Segal MS, 2006, DIABETES, V55, P102, DOI 10.2337/diabetes.55.01.06.db05-0803
   Shi Q, 1998, BLOOD, V92, P362, DOI 10.1182/blood.V92.2.362.414k38_362_367
   Shibata R, 2008, FEBS LETT, V582, P1607, DOI 10.1016/j.febslet.2008.04.006
   Shulman GI, 2000, J CLIN INVEST, V106, P171, DOI 10.1172/JCI10583
   Siegel David, 2007, Metabolic Syndrome and Related Disorders, V5, P211, DOI 10.1089/met.2007.0016
   Sieveking DP, 2008, J AM COLL CARDIOL, V51, P660, DOI 10.1016/j.jacc.2007.09.059
   Sorrentino SA, 2007, CIRCULATION, V116, P163, DOI 10.1161/CIRCULATIONAHA.106.684381
   Steinberg HO, 1996, J CLIN INVEST, V97, P2601, DOI 10.1172/JCI118709
   Steppan CM, 2001, NATURE, V409, P307, DOI 10.1038/35053000
   Strehlow K, 2003, CIRCULATION, V107, P3059, DOI 10.1161/01.CIR.0000077911.81151.30
   Takaya T, 2007, ARTERIOSCL THROM VAS, V27, P1632, DOI 10.1161/ATVBAHA.107.142182
   Tanaka T, 2003, P NATL ACAD SCI USA, V100, P15924, DOI 10.1073/pnas.0306981100
   Tanner FC, 2000, CIRCULATION, V101, P1982, DOI 10.1161/01.CIR.101.16.1982
   Tepper OM, 2002, CIRCULATION, V106, P2781, DOI 10.1161/01.CIR.0000039526.42991.93
   Thum T, 2006, CARDIOVASC RES, V70, P50, DOI 10.1016/j.cardiores.2006.01.002
   Thum T, 2005, J AM COLL CARDIOL, V46, P1693, DOI 10.1016/j.jacc.2005.04.066
   Thum T, 2007, CIRC RES, V100, P434, DOI 10.1161/01.RES.0000257912.78915.af
   Thum T, 2007, DIABETES, V56, P666, DOI 10.2337/db06-0699
   Thum T, 2007, ARTERIOSCL THROM VAS, V27, P748, DOI 10.1161/01.ATV.0000258787.18982.73
   Tilg H, 2008, MOL MED, V14, P222, DOI 10.2119/2007-00119.Tilg
   Tousoulis D, 2006, CYTOKINE GROWTH F R, V17, P225, DOI 10.1016/j.cytogfr.2006.04.003
   Turner RC, 1998, LANCET, V352, P854, DOI 10.1016/s0140-6736(98)07037-8
   Unwin N, 2002, DIABETIC MED, V19, P708, DOI 10.1046/j.1464-5491.2002.00835.x
   Urao N, 2008, CIRC RES, V103, P212, DOI 10.1161/CIRCRESAHA.108.176230
   Urao N, 2006, CIRC RES, V98, P1405, DOI 10.1161/01.RES.0000224117.59417.f3
   Urbich C, 2005, FASEB J, V19, P974, DOI 10.1096/fj.04-2727fje
   Ushio-Fukai M, 2006, CARDIOVASC RES, V71, P226, DOI 10.1016/j.cardiores.2006.04.015
   Vecchione C, 2002, DIABETES, V51, P168, DOI 10.2337/diabetes.51.1.168
   Verma S, 2004, CIRCULATION, V109, P2058, DOI 10.1161/01.CIR.0000127577.63323.24
   Walsh MF, 1996, ENDOCRINOLOGY, V137, P1798, DOI 10.1210/en.137.5.1798
   Wang CH, 2004, CIRCULATION, V109, P1392, DOI 10.1161/01.CIR.0000123231.49594.21
   Wang CH, 2006, AM HEART J, V152, DOI 10.1016/j.ahj.2006.07.029
   Wang CH, 2006, J MOL CELL CARDIOL, V41, P34, DOI 10.1016/j.yjmcc.2006.03.006
   Wang XL, 2006, DIABETES, V55, P2301, DOI 10.2337/db05-1574
   Wassmann S, 2006, CIRC RES, V99, pE74, DOI 10.1161/01.RES.0000246095.90247.d4
   Werner C, 2007, DIABETES, V56, P2609, DOI 10.2337/db07-0069
   Werner N, 2006, ARTERIOSCL THROM VAS, V26, P112, DOI 10.1161/01.ATV.0000191634.13057.15
   Werner N, 2005, NEW ENGL J MED, V353, P999, DOI 10.1056/NEJMoa043814
   Werner N, 2003, CIRC RES, V93, pE17, DOI 10.1161/01.RES.0000083812.30141.74
   Westerweel PE, 2008, EUR HEART J, V29, P2808, DOI 10.1093/eurheartj/ehn431
   Wheatcroft SB, 2003, DIABETIC MED, V20, P255, DOI 10.1046/j.1464-5491.2003.00869.x
   Wheatcroft SB, 2004, DIABETES, V53, P2645, DOI 10.2337/diabetes.53.10.2645
   Williams IL, 2005, OBES SURG, V15, P1055, DOI 10.1381/0960892054621134
   Williams IL, 2002, INT J OBESITY, V26, P754, DOI 10.1038/sj.ijo.0801995
   Wolk R, 2005, ATHEROSCLEROSIS, V183, P131, DOI 10.1016/j.atherosclerosis.2005.03.048
   Wollert KC, 2004, LANCET, V364, P141, DOI 10.1016/S0140-6736(04)16626-9
   Yoder MC, 2007, BLOOD, V109, P1801, DOI 10.1182/blood-2006-08-043471
   Yoshioka T, 2006, CARDIOVASC RES, V70, P61, DOI 10.1016/j.cardiores.2005.12.013
   Zeng GY, 1996, J CLIN INVEST, V98, P894, DOI 10.1172/JCI118871
   Zeng GY, 2000, CIRCULATION, V101, P1539, DOI 10.1161/01.CIR.101.13.1539
   Zhao XH, 2008, MICROVASC RES, V75, P45, DOI 10.1016/j.mvr.2007.02.009
   Zheng H, 2008, ATHEROSCLEROSIS, V201, P36, DOI 10.1016/j.atherosclerosis.2008.02.011
   Zhu WD, 2008, CLIN SCI, V114, P361, DOI 10.1042/CS20070347
NR 185
TC 58
Z9 71
U1 0
U2 13
PU PORTLAND PRESS LTD
PI LONDON
PA 5TH FLR, 90 HIGH HOLBORN, LONDON WC1V 6LJ, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD SEP
PY 2009
VL 117
IS 5-6
BP 173
EP 190
DI 10.1042/CS20080263
PG 18
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 492GU
UT WOS:000269643900001
PM 19630751
DA 2025-06-11
ER

PT J
AU John, A
   Desai, R
   Richards, M
   Gaysina, D
   Stott, J
AF John, Amber
   Desai, Roopal
   Richards, Marcus
   Gaysina, Darya
   Stott, Joshua
TI Role of cardiometabolic risk in the association between accumulation of
   affective symptoms across adulthood and mid-life cognitive function:
   national cohort study
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Depression; anxiety; cognitive ageing; cardiometabolic health;
   longitudinal; birth cohort
ID PSYCHOLOGICAL DISTRESS; ALZHEIMERS-DISEASE; DEMENTIA; DEPRESSION;
   DISORDERS
AB Background
   Affective symptoms are associated with cognition in mid-life and later life. However, the role of cardiometabolic risk in this association has not been previously examined.
   Aims
   To investigate how cardiometabolic risk contributes to associations between affective symptoms and mid-life cognition.
   Method
   Data were used from the National Child Development Study (NCDS), a sample of people born in Britain during one week in 1958. Measures of immediate and delayed memory, verbal fluency and information processing speed and accuracy were available at age 50. Affective symptoms were assessed at ages 23, 33 and 42 years and a measure of accumulation was derived. A cardiometabolic risk score was calculated from nine cardiometabolic biomarkers at age 44. Path models were run to test these associations, adjusting for sex, education, socioeconomic position and affective symptoms at age 50.
   Results
   After accounting for missing data using multiple imputation, path models indicated significant indirect associations between affective symptoms and mid-life immediate memory (beta = -0.002, s.e. = 0.001, P = 0.009), delayed memory (beta = -0.002, s.e. = 0.001, P = 0.02) and verbal fluency (beta = -0.002, s.e. = 0.001, P = 0.045) through cardiometabolic risk.
   Conclusions
   These findings suggest that cardiometabolic risk may play an important role in the association between affective symptoms and cognitive function (memory and verbal fluency). Results contribute to understanding of biological mechanisms underlying associations between affective symptoms and cognitive ageing, which can have implications for early detection of, and intervention for, those at risk of poorer cognitive outcomes.
C1 [John, Amber; Desai, Roopal; Stott, Joshua] UCL, Res Dept Clin Educ & Hlth Psychol, London, England.
   [Richards, Marcus] UCL, MRC Unit Lifelong Hlth & Ageing, London, England.
   [Gaysina, Darya] Univ Sussex, Sch Psychol, EDGE Lab, Brighton, E Sussex, England.
C3 University of London; University College London; University of London;
   University College London; University of Sussex
RP John, A (corresponding author), UCL, Res Dept Clin Educ & Hlth Psychol, London, England.
EM a.john@ucl.ac.uk
RI stott, josh/AAX-6275-2021
OI Stott, Joshua/0000-0003-1361-053X; Richards, Marcus/0000-0001-9191-2192;
   Desai, Roopal/0000-0003-4221-1546; John, Amber/0000-0002-8207-7698
FU Economic and Social Research Council (ESRC) [ES/J500173/1]; Alzheimer's
   Society [AS-PG-18-013]; ESRC [ES/M001660/1]; Wellcome Trust; Medical
   Research Council (MRC) [MR/N01104X/1, ES/S008349/1]; MRC
   [108439/Z/15/Z]; Medical Research Council 58READIE Project [WT095219MA,
   G1001799]; ESRC [ES/S008349/1] Funding Source: UKRI; MRC [MC_UU_00019/3]
   Funding Source: UKRI
FX Economic and Social Research Council (ESRC) (D.G., A.J.: grant number:
   ES/J500173/1). Alzheimer's Society (J.S., R.D., A.J., M.R.: MODIFY
   Project, grant number AS-PG-18-013). Data governance was provided by the
   METADAC data access committee, funded by the ESRC, Wellcome Trust and
   Medical Research Council (MRC) (2015-2018: grant number MR/N01104X/1;
   2018-2020: grant number ES/S008349/1). Data and samples generated by the
   NCDS 1958 Birth Cohort is managed by the Centre for Longitudinal Studies
   at the UCL Institute of Education, funded by the ESRC (grant number
   ES/M001660/1). Access to these resources was enabled via the Wellcome
   Trust and MRC (58FORWARDS grant 108439/Z/15/Z). Before 2015 biomedical
   resources were maintained under the Wellcome Trust and Medical Research
   Council 58READIE Project (grant numbers WT095219MA and G1001799).
   Funders were not involved in the study design; collection, analysis, and
   interpretation of data; writing the report; or in the decision to submit
   the article for publication.
CR Bhat NR, 2010, J NEUROCHEM, V115, P551, DOI 10.1111/j.1471-4159.2010.06978.x
   Bonnet F, 2005, ATHEROSCLEROSIS, V178, P339, DOI 10.1016/j.atherosclerosis.2004.08.035
   Bowling Ann, 2016, BMC Psychol, V4, P58
   Brown M., 2010, NCDS cognitive assessments at age 50: initial results
   Butters Meryl A, 2008, Dialogues Clin Neurosci, V10, P345
   da Silva J, 2013, BRIT J PSYCHIAT, V202, P177, DOI 10.1192/bjp.bp.111.101931
   Dhar AK, 2016, FRONT PSYCHIATRY, V7, DOI 10.3389/fpsyt.2016.00033
   Douglas J.W. B., 1964, The home and the school: A study of ability and attainment in the primary school
   Elliott J., 2014, Refining childhood social class measures in the 1958 British cohort study
   Fuller E., 2006, TECHNICAL REPORT NAT
   Hatch SL, 2007, J GERONTOL B-PSYCHOL, V62, pS404, DOI 10.1093/geronb/62.6.S404
   James SN, 2018, J AFFECT DISORDERS, V241, P348, DOI 10.1016/j.jad.2018.07.078
   John A, 2019, PSYCHOL MED, V49, P353, DOI 10.1017/S0033291718001137
   John A, 2019, BRIT J PSYCHIAT, V215, P675, DOI 10.1192/bjp.2019.24
   Kaplan GA, 2001, INT J EPIDEMIOL, V30, P256, DOI 10.1093/ije/30.2.256
   Livingston Gill, 2017, Lancet, V390, P2673, DOI 10.1016/S0140-6736(17)31363-6
   Muthen L.K., 2017, MPLUS USERS GUIDE
   Power C, 2006, INT J EPIDEMIOL, V35, P34, DOI 10.1093/ije/dyi183
   Raffaitin C, 2009, DIABETES CARE, V32, P169, DOI 10.2337/dc08-0272
   Richards M, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-024404
   Rodgers B, 1999, SOC PSYCH PSYCH EPID, V34, P333, DOI 10.1007/s001270050153
   Shepherd P., 2008, USER GUIDE BIOMEDICA
   Thomas AJ, 2004, J AFFECT DISORDERS, V79, P81, DOI 10.1016/S0165-0327(02)00349-x
   Winning A, 2016, PSYCHOSOM MED, V78, P1019, DOI 10.1097/PSY.0000000000000409
   Winning A, 2015, J AM COLL CARDIOL, V66, P1577, DOI 10.1016/j.jacc.2015.08.021
NR 25
TC 8
Z9 8
U1 0
U2 2
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1250
EI 1472-1465
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD MAY
PY 2021
VL 218
IS 5
BP 254
EP 260
AR PII S0007125020001233
DI 10.1192/bjp.2020.123
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA RU0TY
UT WOS:000644866600007
PM 32662372
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Macgregor, AP
   Borghese, MM
   Janssen, I
AF Macgregor, Anne P.
   Borghese, Michael M.
   Janssen, Ian
TI Is replacing time spent in 1 type of physical activity with another
   associated with health in children?
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE behaviour; fat mass; mathematical modelling; epidemiology; physical
   activity; pediatrics
ID YOUTH; INTENSITY; FITNESS; PLAY
AB Altering the proportion of total physical activity time accumulated while participating in different types of physical activity may influence health. Our objective was to use observational data to estimate whether replacing time from 1 type of physical activity with another is associated with physical and mental health indicators among children. Participants were 385 children aged 10-13 years. They wore a Global Positioning System watch and accelerometer and completed an activity log for 7 days. Data from these instruments was used to estimate time spent in outdoor active play, organized sport, curriculum-based physical activity at school, and active transportation. A cardiometabolic risk factor score was created from body fat, resting heart rate, and resting blood pressure measures. An internalizing symptoms score was created using anxiety and depression symptom questionnaire items. Isotemporal substitution models estimated if health indicators changed when time in 1 type of physical activity was replaced with equivalent time from another. The results indicated that time spent in all types of physical activity combined was associated with the cardiometabolic risk factor and internalizing symptom scores. Replacing active transportation with outdoor active play was associated with an increase in the internalizing symptoms score but a decrease in the cardiometabolic risk factor score. The internalizing symptoms score decreased when active transportation was replaced by equivalent time in organized sport. Other time substitutions were not significant. In conclusion, the total time spent participating in physical activity and not a specific type of physical activity was the most consistent correlate of the health indicators.
C1 [Macgregor, Anne P.; Borghese, Michael M.; Janssen, Ian] Queens Univ, Sch Kinesiol & Hlth Studies, Kingston, ON K7L 3N6, Canada.
   [Janssen, Ian] Queens Univ, Dept Publ Hlth Sci, Kingston, ON, Canada.
C3 Queens University - Canada; Queens University - Canada
RP Janssen, I (corresponding author), Queens Univ, Sch Kinesiol & Hlth Studies, Kingston, ON K7L 3N6, Canada.; Janssen, I (corresponding author), Queens Univ, Dept Publ Hlth Sci, Kingston, ON, Canada.
EM ian.janssen@queensu.ca
RI Janssen, Ian/B-7700-2009
OI Janssen, Ian/0000-0003-2159-3012
FU Heart and Stroke Foundation of Canada
FX This study was funded by a grant-in-aide from the Heart and Stroke
   Foundation of Canada. The authors would like to thank the participants
   for their commitment to the study and the many graduate and
   undergraduate students who assisted with data collection and cleaning.
CR Berto R, 2014, BEHAV SCI-BASEL, V4, P394, DOI 10.3390/bs4040394
   Biddle SJH, 2011, INT REV SPORT EXER P, V4, P25, DOI 10.1080/1750984X.2010.548528
   Borghese MM, 2018, BMC PUBLIC HEALTH, V18, DOI 10.1186/s12889-018-5268-1
   BOYLE MH, 1987, ARCH GEN PSYCHIAT, V44, P826
   BOYLE MH, 1993, J CHILD PSYCHOL PSYC, V34, P189, DOI 10.1111/j.1469-7610.1993.tb00979.x
   Brussoni M, 2015, INT J ENV RES PUB HE, V12, P6423, DOI 10.3390/ijerph120606423
   Carlson JA, 2015, MED SCI SPORT EXER, V47, P662, DOI 10.1249/MSS.0000000000000446
   Chastin SFM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0139984
   Colley Rachel, 2010, Health Rep, V21, P63
   Dumuid D, 2018, STAT METHODS MED RES, V27, P3726, DOI 10.1177/0962280217710835
   Eime RM, 2013, INT J BEHAV NUTR PHY, V10, DOI 10.1186/1479-5868-10-98
   Hallal PC, 2012, LANCET, V380, P247, DOI 10.1016/S0140-6736(12)60646-1
   Janssen I, 2014, CAN J PUBLIC HEALTH, V105, pE22, DOI 10.17269/cjph.105.4154
   Janssen I, 2010, INT J BEHAV NUTR PHY, V7, DOI 10.1186/1479-5868-7-40
   Larouche R, 2014, J PHYS ACT HEALTH, V11, P206, DOI 10.1123/jpah.2011-0345
   Mark AE, 2011, J PHYS ACT HEALTH, V8, P164, DOI 10.1123/jpah.8.2.164
   Markevych I, 2017, ENVIRON RES, V158, P301, DOI 10.1016/j.envres.2017.06.028
   Mekary RA, 2013, AM J EPIDEMIOL, V178, P474, DOI 10.1093/aje/kws590
   Poitras VJ, 2016, APPL PHYSIOL NUTR ME, V41, pS197, DOI 10.1139/apnm-2015-0663
   Puyau MR, 2002, OBES RES, V10, P150, DOI 10.1038/oby.2002.24
   Rasberry CN, 2011, PREV MED, V52, pS10, DOI 10.1016/j.ypmed.2011.01.027
   Rubin DB, 1987, Multiple Imputation for Nonresponse in Surveys, DOI [10.1002/9780470316696, DOI 10.1002/9780470316696]
   Ruiz JR, 2006, AM J CLIN NUTR, V84, P299
   Saunders LE, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0069912
   Sterdt E, 2014, HEALTH EDUC J, V73, P72, DOI 10.1177/0017896912469578
   Tremblay MS, 2016, J PHYS ACT HEALTH, V13, pS85, DOI 10.1123/jpah.2016-0641
NR 26
TC 7
Z9 7
U1 1
U2 23
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD SEP
PY 2019
VL 44
IS 9
BP 937
EP 943
DI 10.1139/apnm-2018-0323
PG 7
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA IT7VU
UT WOS:000483088200003
PM 30653335
DA 2025-06-11
ER

PT J
AU Aboonabi, A
   Meyer, RR
   Gaiz, A
   Singh, I
AF Aboonabi, Anahita
   Meyer, Roselyn Rose
   Gaiz, Almottesembellah
   Singh, Indu
TI Anthocyanins in berries exhibited anti-atherogenicity and antiplatelet
   activities in a metabolic syndrome population
SO NUTRITION RESEARCH
LA English
DT Article
ID C-REACTIVE PROTEIN; OXIDATIVE STRESS; PLATELET ACTIVATION; SUBCLINICAL
   ATHEROSCLEROSIS; DIETARY POLYPHENOLS; INSULIN-RESISTANCE;
   ALPHA-GLUCOSIDASE; NITRIC-OXIDE; P-SELECTIN; URIC-ACID
AB Metabolic syndrome (MetS) is a global challenge for atherosclerosis. It was hypothesized that a four-week consumption of anthocyanin supplements by MetS patients who had three or more risk factors linked with metabolic syndrome would have a greater improvement in cardiometabolic biomarkers and would also reduce the risk of thrombosis. A total of 55 participants in two groups of Normal healthy and MetS (age 25-75y) were given 320 mg anthocyanin supplements twice daily for 4 weeks. Platelet coagulant activities, lipid profiles, fasting blood glucose, and inflammatory and oxidative stress biomarkers were measured before and after supplementation to evaluate the atheroprotective effects of anthocyanins in the study subjects. Four weeks of anthocyanin supplementation significantly decreased cardiometabolic risk factors including the average serum fasting blood glucose (FBG) (by 13.3%, P < .05) and lipid profiles by significant reduction in triglyceride (by 24.9%, P < .05) and LDL-C (by 33.1%, P < .05) in the MetS group. Anthocyanin supplementation also decreased high sensitivity C-reactive protein (hs-CRP) level (by 28%, P < .05) in females. However, no significant differences in serum UA (uric acid) and HDL-C were observed between anthocyanin pre- and post-treatment in both groups. Moreover, Anthocyanin supplements decreased ADP-induced platelet activation configuration expressed as P-selectin by 40% (P < .05). There was a positive correlation between decreased hs-CRP values and the levels of LDL-C and FBG in the MetS group (P < .05). These results support the hypothesis that anthocyanin supplementation exerts anti-atherogenicity effects by improving cardiometabolic risk factors and reducing thrombogenicity in the MetS population. (C) 2020 Elsevier Inc. All rights reserved.
C1 [Aboonabi, Anahita; Meyer, Roselyn Rose; Gaiz, Almottesembellah; Singh, Indu] Sch Med Sci, Gold Coast Campus,Parklands Dr, Southport, Qld 4222, Australia.
RP Aboonabi, A (corresponding author), Sch Med Sci, Gold Coast Campus,Parklands Dr, Southport, Qld 4222, Australia.
EM anahita.aboonabi@griffithuni.edu.au; r.rosemyer@griffith.edu.au;
   Almottesembellah.gaiz@griffith.edu.au; i.singh@griffith.edu.au
RI GAIZ, ALMOTTESEMBELLAH/JZS-9831-2024
OI Aboonabi, Anahita/0000-0001-6213-6673; Singh, Indu/0000-0002-0498-4209;
   Gaiz, Almottesembellah/0000-0003-1528-9356
CR Aboonabi A, 2019, J HUM HYPERTENS, P1
   Aboonabi A, 2020, CHEM-BIOL INTERACT, V317, DOI 10.1016/j.cbi.2020.108940
   Ahluwalia A, 2004, P NATL ACAD SCI USA, V101, P1386, DOI 10.1073/pnas.0304264101
   Akkarachiyasit S, 2010, INT J MOL SCI, V11, P3387, DOI 10.3390/ijms11093387
   Alfonso F, 2013, J AM COLL CARDIOL, V61, P2056, DOI 10.1016/j.jacc.2013.03.004
   Alvarez-Suarez JM, 2014, J NUTR BIOCHEM, V25, P289, DOI 10.1016/j.jnutbio.2013.11.002
   Ambrose J. A., 2019, EMJ, V4, P71, DOI [10.33590/emj/10314648, DOI 10.33590/EMJ/10314648]
   Avan A, 2018, J CELL PHYSIOL, V233, P8508, DOI 10.1002/jcp.26791
   Bäck M, 2019, FRONT CARDIOVASC MED, V5, DOI 10.3389/fcvm.2018.00196
   Bhagwat S., 2014, Database for Flavonoid Content of Selected Foods
   Braakhuis AJ, 2011, INT J SPORT NUTR EXE, V21, P105, DOI 10.1123/ijsnem.21.2.105
   Cassidy A, 2016, AM J CLIN NUTR, V104, P587, DOI 10.3945/ajcn.116.133132
   Cesari M, 2012, J GERONTOL A-BIOL, V67, P671, DOI 10.1093/gerona/glr246
   Cheng DM, 2014, NUTRITION, V30, pS52, DOI 10.1016/j.nut.2014.02.022
   Conway DSG, 2004, J AM COLL CARDIOL, V43, P2075, DOI 10.1016/j.jacc.2003.11.062
   Dommermuth R, 2018, PRIMARY CARE, V45, P109, DOI 10.1016/j.pop.2017.10.003
   Esteve E, 2005, CLIN NUTR, V24, P16, DOI 10.1016/j.clnu.2004.08.004
   Fernández-Friera L, 2017, J AM COLL CARDIOL, V70, P2979, DOI 10.1016/j.jacc.2017.10.024
   Folli F, 2011, CURR DIABETES REV, V7, P313, DOI 10.2174/157339911797415585
   Freedman JE, 2008, ARTERIOSCL THROM VAS, V28, pS11, DOI 10.1161/ATVBAHA.107.159178
   Fröhlich M, 2000, DIABETES CARE, V23, P1835, DOI 10.2337/diacare.23.12.1835
   GABOURY J, 1993, AM J PHYSIOL, V265, pH862, DOI 10.1152/ajpheart.1993.265.3.H862
   Ghoshal K, 2014, SCI WORLD J, DOI 10.1155/2014/781857
   Giusti MM, 2003, BIOCHEM ENG J, V14, P217, DOI 10.1016/S1369-703X(02)00221-8
   Grosso G, 2017, AM J EPIDEMIOL, V185, P1304, DOI 10.1093/aje/kww207
   Hagberg IA, 2000, PLATELETS, V11, P137
   Halvorsen BL, 2006, AM J CLIN NUTR, V84, P95, DOI 10.1093/ajcn/84.1.95
   He JA, 2010, ANNU REV FOOD SCI T, V1, P163, DOI 10.1146/annurev.food.080708.100754
   Herder C, 2011, CLIN PHARMACOL THER, V90, P52, DOI 10.1038/clpt.2011.93
   Iwai K, 2006, J AGR FOOD CHEM, V54, P4588, DOI 10.1021/jf0606353
   Joseph SV, 2014, J AGR FOOD CHEM, V62, P3886, DOI 10.1021/jf4044056
   Kähkönen MP, 2003, J AGR FOOD CHEM, V51, P628, DOI 10.1021/jf025551i
   Krga I, 2019, J AGR FOOD CHEM, V67, P1771, DOI 10.1021/acs.jafc.8b06737
   KUBES P, 1991, P NATL ACAD SCI USA, V88, P4651, DOI 10.1073/pnas.88.11.4651
   Lavie CJ, 2018, NAT REV CARDIOL, V15, P45, DOI 10.1038/nrcardio.2017.108
   Li D, 2015, J NUTR, V145, P742, DOI 10.3945/jn.114.205674
   Liuzzo G., 2019, CLIN IMMUNOLOGY, P935
   Michelson AD, 2000, METHODS, V21, P259, DOI 10.1006/meth.2000.1006
   Nandkeolyar S, 2019, ATHEROSCLEROSIS, V282, P80, DOI 10.1016/j.atherosclerosis.2019.01.012
   Nizamutdinova IT, 2009, MOL NUTR FOOD RES, V53, P1419, DOI 10.1002/mnfr.200800526
   Overall J, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18020422
   Qin Y, 2009, AM J CLIN NUTR, V90, P485, DOI 10.3945/ajcn.2009.27814
   RCPA, 2015, PCPA MAN ROYAL COLL
   Rechner AR, 2005, THROMB RES, V116, P327, DOI 10.1016/j.thromres.2005.01.002
   Reis JF, 2016, J TRANSL MED, V14, DOI 10.1186/s12967-016-1076-5
   Ridker PM, 2008, J PERIODONTOL, V79, P1544, DOI 10.1902/jop.2008.080249
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Ruggiero C, 2006, EUR HEART J, V27, P1174, DOI 10.1093/eurheatj/ehi879
   Ruggiero C, 2007, AM J CARDIOL, V100, P115, DOI 10.1016/j.amjcard.2007.02.065
   Santhakumar AB, 2014, J HUM NUTR DIET, V27, P1, DOI 10.1111/jhn.12177
   Scazzocchio B, 2011, DIABETES, V60, P2234, DOI 10.2337/db10-1461
   Shah K, 2018, CHOLESTEROL, DOI 10.1155/2018/8450793
   Sobotková A, 2009, FREE RADICAL BIO MED, V47, P1707, DOI 10.1016/j.freeradbiomed.2009.09.015
   Spahis S, 2017, ANTIOXID REDOX SIGN, V26, P445, DOI 10.1089/ars.2016.6756
   Vendrame S, 2015, NUTR REV, V73, P348, DOI 10.1093/nutrit/nuu066
   Vendrame S, 2014, BRIT J NUTR, V111, P194, DOI 10.1017/S0007114513002390
   Viles-Gonzalez JF, 2006, CURR MOL MED, V6, P489, DOI 10.2174/156652406778018707
   Wang X, 2014, BRIT J NUTR, V111, P1, DOI 10.1017/S000711451300278X
   Zhu YN, 2014, J CLIN ENDOCR METAB, V99, P561, DOI 10.1210/jc.2013-2845
NR 59
TC 39
Z9 40
U1 0
U2 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD APR
PY 2020
VL 76
BP 82
EP 93
DI 10.1016/j.nutres.2020.02.011
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA LL5FV
UT WOS:000531584200008
PM 32217379
DA 2025-06-11
ER

PT J
AU Golding, H
   Ritonja, JA
   Day, AG
   Aronson, KJ
   Tranmer, J
AF Golding, Haley
   Ritonja, Jennifer A.
   Day, Andrew G.
   Aronson, Kristan J.
   Tranmer, Joan
TI Modeling the relationship between shift work and cardiometabolic risk
   through circadian disruption, sleep and stress pathways
SO CHRONOBIOLOGY INTERNATIONAL
LA English
DT Article
DE Shift work; circadian disruption; cardiovascular risk; mechanistic
   pathways; metabolic syndrome
ID METABOLIC SYNDROME; CARDIOVASCULAR RISK; CORTISOL PRODUCTION;
   ASSOCIATION; DURATION; QUALITY; NURSES
AB The purpose of this study is to elucidate the multiple pathways linking shift work exposure to cardiometabolic risk (CMR) through the intermediates of circadian disruption, sleep disturbances, and stress. A cross-sectional study was conducted at Kingston Health Sciences Center that included female hospital workers, 160 who worked a day-only schedule and 168 who worked rotating days and nights. Participants completed questionnaires, a clinical exam, and wore accelerometers to collect sleep data for 8 days. Participants also collected urine samples at each void during a 24-h collection period, on the day shift for day-only workers and the night shift for rotating shift workers, for cortisol and melatonin measures. We adapted and tested a conceptual model proposed by Knutsson and Boggild for circadian disruption, sleep, and stress mechanistic pathways linking shift work to CMR using structural equation modeling techniques. Status as a rotating shift worker was associated with increased circadian disruption of cortisol and melatonin production compared to day-only workers (P < .001). Increased circadian disruption was associated with an increased CMR (P = .01). Rotating shift work was associated with sleep disturbances (P = .002) and increased job stress (P < .001), but neither was associated with CMR. We conclude that rotating shift work is associated indirectly with increased CMR. This association is mediated by circadian disruption as indicated by attenuated melatonin and cortisol, and flatter cortisol curves.
C1 [Golding, Haley; Ritonja, Jennifer A.; Day, Andrew G.; Aronson, Kristan J.; Tranmer, Joan] Queens Univ, Dept Publ Hlth Sci, Kingston, ON, Canada.
   [Aronson, Kristan J.] Queens Univ, Canc Res Inst, Kingston, ON, Canada.
   [Tranmer, Joan] Queens Univ, Sch Nursing, 92 Barrie St, Kingston, ON K7L 3N6, Canada.
C3 Queens University - Canada; Queens University - Canada; Queens
   University - Canada
RP Tranmer, J (corresponding author), Queens Univ, Sch Nursing, 92 Barrie St, Kingston, ON K7L 3N6, Canada.
EM tranmerj@queensu.ca
RI Ritonja, Jennifer/ADS-5126-2022
OI Tranmer, Joan/0000-0001-5192-5992; Day, Andrew/0000-0002-1095-5703;
   Golding, Haley/0000-0001-5912-5869
FU Canadian Institute for Health Research; Workplace Safety and Insurance
   Board (Ontario)
FX This study was funded by the Canadian Institute for Health Research and
   the Workplace Safety and Insurance Board (Ontario).
CR ANDERSON JC, 1988, PSYCHOL BULL, V103, P411, DOI 10.1037/0033-2909.103.3.411
   Baughman P, 2016, AM J HUM BIOL, V28, P138, DOI 10.1002/ajhb.22748
   Boggild H, 2001, SCAND J WORK ENV HEA, V27, P97, DOI 10.5271/sjweh.595
   Buja A, 2013, INT J OCCUP MED ENV, V26, P511, DOI 10.2478/s13382-013-0122-2
   COLE RJ, 1992, SLEEP, V15, P461, DOI 10.1093/sleep/15.5.461
   Dehring T, 2018, BMC HEALTH SERV RES, V18, DOI 10.1186/s12913-018-3402-5
   DOBKIN PL, 1991, PSYCHOTHER PSYCHOSOM, V56, P185, DOI 10.1159/000288555
   Fekedulegn DB, 2007, PSYCHOSOM MED, V69, P651, DOI 10.1097/PSY.0b013e31814c405c
   Forrestel AC, 2017, DIABETOLOGIA, V60, P808, DOI 10.1007/s00125-016-4175-1
   Gimble JM, 2009, J APPL PHYSIOL, V107, P1629, DOI 10.1152/japplphysiol.00090.2009
   Härmä M, 2006, SCAND J WORK ENV HEA, V32, P502
   Hooper D., 2008, The Electronic Journal of Business Research Methods, V6, P53, DOI [10.21427/D7CF7R, DOI 10.3109/03005364000000039]
   Hung EWM, 2016, CHRONOBIOL INT, V33, P1045, DOI 10.1080/07420528.2016.1196695
   Iacobucci D, 2010, J CONSUM PSYCHOL, V20, P90, DOI 10.1016/j.jcps.2009.09.003
   Iftikhar IH, 2015, ANN AM THORAC SOC, V12, P1364, DOI 10.1513/AnnalsATS.201504-190OC
   Ingram W., 2016, MODERATING EFFECT SH
   Janczura M, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0133750
   Ju SY, 2013, NUTR DIABETES, V3, DOI 10.1038/nutd.2013.8
   Karasek R, 1998, J Occup Health Psychol, V3, P322, DOI 10.1037/1076-8998.3.4.322
   Knutsson A, 2000, Rev Environ Health, V15, P359
   Korsiak J, 2018, J SLEEP RES, V27, DOI 10.1111/jsr.12579
   Korsiak J, 2018, OCCUP ENVIRON MED, V75, P132, DOI 10.1136/oemed-2017-104371
   Lajoie P, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2014-007327
   Lecca LI, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15091952
   Leung M, 2016, CANCER EPIDEM BIOMAR, V25, P830, DOI 10.1158/1055-9965.EPI-15-1178
   Li J, 2018, J OCCUP MED TOXICOL, V13, DOI 10.1186/s12995-018-0204-y
   Li J, 2017, J EXP EDUC, V85, P231, DOI 10.1080/00220973.2015.1134418
   Lian Y, 2019, PSYCHIAT RES, V274, P66, DOI 10.1016/j.psychres.2019.01.096
   Maury E, 2010, CIRC RES, V106, P447, DOI 10.1161/CIRCRESAHA.109.208355
   Motamed N, 2016, ARCH IRAN MED, V19, P110, DOI 0161902/AIM.008
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Pietroiusti A, 2010, OCCUP ENVIRON MED, V67, P54, DOI 10.1136/oem.2009.046797
   Ragnarsson O, 2015, STEROIDS, V101, P71, DOI 10.1016/j.steroids.2015.06.007
   Ritonja J, 2018, CAN J CARDIOL, V34, P683, DOI 10.1016/j.cjca.2018.02.006
   Rydz E, 2020, ANN WORK EXPOS HEAL, V64, P270, DOI 10.1093/annweh/wxaa001
   Ryu E, 2011, BEHAV RES METHODS, V43, P1066, DOI 10.3758/s13428-011-0115-7
   Tahghighi M, 2017, J ADV NURS, V73, P2065, DOI 10.1111/jan.13283
   Vyas MV, 2012, BMJ-BRIT MED J, V345, DOI 10.1136/bmj.e4800
   Wang F, 2014, OBES REV, V15, P709, DOI 10.1111/obr.12194
   Watanabe K, 2018, OBES REV, V19, P1557, DOI 10.1111/obr.12725
   WIMBERLEY RC, 1975, EDUC PSYCHOL MEAS, V35, P693, DOI 10.1177/001316447503500322
NR 41
TC 4
Z9 4
U1 3
U2 10
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0742-0528
EI 1525-6073
J9 CHRONOBIOL INT
JI Chronobiol. Int.
PD MAY 4
PY 2022
VL 39
IS 5
BP 704
EP 713
DI 10.1080/07420528.2022.2032124
EA JAN 2022
PG 10
WC Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Physiology
GA 1D9ZB
UT WOS:000749369900001
PM 35100920
DA 2025-06-11
ER

PT J
AU Teixeira, PJR
   Rochal, FL
AF Ribeiro Teixeira, Paulo Jose
   Rochal, Fabio Lopes
TI The prevalence of metabolic syndrome among psychiatric inpatients in
   Brazil
SO REVISTA BRASILEIRA DE PSIQUIATRIA
LA English
DT Article
DE metabolic syndrome X; mental disorders; schizophrenia; bipolar disorder;
   depression
ID 3RD NATIONAL-HEALTH; ALCOHOL-CONSUMPTION; YOUNG-ADULTS; RISK-FACTORS;
   SCHIZOPHRENIA; DYSLIPIDEMIA; DEFINITION; DISORDER; US
AB Objective: Metabolic syndrome is a highly prevalent disorder among the general population. Studies show an even higher prevalence among psychiatric patients. The objective of this study is to assess the prevalence of metabolic syndrome among inpatients of a psychiatric ward of a general hospital in Brazil and correlate it with their respective psychiatric diagnoses and with the antipsychotics and mood stabilizers used. Method: 170 inpatients (mean age: 45.6 years) were evaluated according to the National Cholesterol Education Program criteria for metabolic syndrome, with a modification of the criteria for blood pressure and fasting glucose. Results: The prevalence found was 29.4%, being higher in women (43.6% versus 20.8%, p = 0.002). The prevalence stratified by psychiatric diagnostic was 48.1% for depression, 38.3% for bipolar disorder 31.8% for schizophrenia and schizoaffective disorder, 5.1% for alcoholism, and 23.1% for "other mental disorders". The prevalence for alcoholism was significantly lower than the prevalence rates associated with other diagnostic categories (p = 0.035). After using the multivariate analysis, female gender and use of lithium remained as factors associated with a diagnosis of metabolic syndrome. Conclusions: The prevalence found was 29.4%. Gender (female) and use of lithium were factors significantly associated with the diagnosis of metabolic syndrome.
C1 [Ribeiro Teixeira, Paulo Jose; Rochal, Fabio Lopes] IPSEMG, Belo Horizonte, MG, Brazil.
RP Teixeira, PJR (corresponding author), Rua Fernandes Tourinho,470-Sala 903-Savassi, BR-30112000 Belo Horizonte, MG, Brazil.
EM teixeirapaulo@uol.com.br
RI Rocha, Fabio/B-7753-2008
CR Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   [Anonymous], 2004, J CLIN PSYCHIAT, V65, P267
   [Anonymous], 1992, Am J Hypertens, V5, P207
   [Anonymous], IDF WORLDW DEF MET S
   [Anonymous], 1993, CLASS TRANST MENT CO
   Barcelo A, 2001, Rev Panam Salud Publica, V10, P300, DOI 10.1590/S1020-49892001001100002
   Basu R, 2004, BIPOLAR DISORD, V6, P314, DOI 10.1111/j.1399-5618.2004.00126.x
   Carnethon MR, 2004, DIABETES CARE, V27, P2707, DOI 10.2337/diacare.27.11.2707
   Casey DE, 2004, J CLIN PSYCHIAT, V65, P27
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cohn T, 2004, CAN J PSYCHIAT, V49, P753, DOI 10.1177/070674370404901106
   De Hert MA, 2006, SCHIZOPHR RES, V83, P87, DOI 10.1016/j.schres.2005.12.855
   Sena Eduardo Pondé de, 2003, Braz. J. Psychiatry, V25, P253
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Freiberg MS, 2004, DIABETES CARE, V27, P2954, DOI 10.2337/diacare.27.12.2954
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Hägg S, 2006, INT CLIN PSYCHOPHARM, V21, P93
   Heiskanen T, 2003, J CLIN PSYCHIAT, V64, P575, DOI 10.4088/JCP.v64n0513
   *I BRAS GEOGR EST, 2004, PESQ ORC FAM AN DISP
   Kato Martha M., 2004, Prim Care Companion J Clin Psychiatry, V6, P74
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Leitao-Azevedo CL, 2006, REV BRAS PSIQUIATR, V28, P301, DOI 10.1590/S1516-44462006005000016
   McEvoy JP, 2005, SCHIZOPHR RES, V80, P19, DOI 10.1016/j.schres.2005.07.014
   Meyer Jonathan, 2006, J Psychiatr Pract, V12, P5, DOI 10.1097/00131746-200601000-00002
   REAVEN GM, 1994, J INTERN MED, V236, P13
   Saari KM, 2005, J CLIN PSYCHIAT, V66, P559, DOI 10.4088/JCP.v66n0503
   *SOC BRAS DIAB, 2004, HIPERTENSAO, V7, P124
   Teixeira Paulo José Ribeiro, 2006, Rev. psiquiatr. Rio Gd. Sul, V28, P186, DOI 10.1590/S0101-81082006000200011
   VESTERGAARD P, 1987, NEUROPSYCHOBIOLOGY, V17, P130, DOI 10.1159/000118351
   Wirshing DA, 2004, J CLIN PSYCHIAT, V65, P13
   Yamada Y, 2003, J OCCUP HEALTH, V45, P293, DOI 10.1539/joh.45.293
   Yoon YS, 2004, AM J CLIN NUTR, V80, P217
   Zimmermann U, 2003, J PSYCHIATR RES, V37, P193, DOI 10.1016/S0022-3956(03)00018-9
NR 35
TC 88
Z9 99
U1 0
U2 5
PU ASSOC BRASILEIRA PSIQUIATRIA
PI SAO PAULO
PA SUBSCRIPTION DEPARTMENT, RUA PEDRO DE TOLEDO, 967 - CASA 01, SAO PAULO,
   SP 04039-032  A, BRAZIL
EI 1809-452X
J9 REV BRAS PSIQUIATR
JI Rev. Bras. Psiquiatr.
PD DEC
PY 2007
VL 29
IS 4
BP 330
EP 336
DI 10.1590/S1516-44462007000400007
PG 7
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA 244PM
UT WOS:000251877800007
PM 18200397
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Pintor, JK
   Mitchell, DC
   Schenker, MB
AF Pintor, Jessie Kemmick
   Mitchell, Diane C.
   Schenker, Marc B.
TI Exploring the Role of Depression as a Moderator of a Workplace Obesity
   Intervention for Latino Immigrant Farmworkers
SO JOURNAL OF IMMIGRANT AND MINORITY HEALTH
LA English
DT Article
DE Migrant farmworkers; Latino immigrants; Obesity; Mental health;
   Intervention
ID FOOD INSECURITY; WEIGHT-LOSS; METABOLIC SYNDROME; INCREASED RISK;
   MENTAL-HEALTH; SHORT-FORM; MIGRANT; US; MAINTENANCE; CALIFORNIA
AB We explored if and how depression moderated the treatment effect of Pasos Saludables, a successful pilot workplace obesity intervention for Latino immigrant farmworkers. The original randomized controlled study assigned 254 participants 2:1 to a 10-session educational intervention versus control. We assessed the relationship between change in BMI (primary outcome) and interaction of treatment allocation and baseline risk for depression. Baseline CES-D scores indicated that 27.3% of participants were at risk for depression. The interaction between treatment allocation and baseline risk for depression was significant (p=0.004). In adjusted modelsamong women, intervention participants with no indication of depression at baseline reduced their BMI by 0.77 on average (95% CI -1.25, -0.30) compared to controls. The reduction im BMI between the intervention group at risk for depression at baselineand eithercontrol was not significantly different from zero. Findings from our post-hoc, exploratory study indicate that depression may inhibit significant weight loss.
C1 [Pintor, Jessie Kemmick; Mitchell, Diane C.; Schenker, Marc B.] Univ Calif Davis, Dept Publ Hlth Sci, Davis, CA 95616 USA.
   [Pintor, Jessie Kemmick] Drexel Univ, Dept Hlth Management & Policy, Dornsife Sch Publ Hlth, 3215 Market St Room 352, Philadelphia, PA 19104 USA.
   [Pintor, Jessie Kemmick] Univ Calif Davis, Ctr Hlth & Environm, 1250 Old Davis Rd, Davis, CA 95616 USA.
C3 University of California System; University of California Davis; Drexel
   University; University of California System; University of California
   Davis
RP Pintor, JK (corresponding author), Univ Calif Davis, Dept Publ Hlth Sci, Davis, CA 95616 USA.; Pintor, JK (corresponding author), Drexel Univ, Dept Hlth Management & Policy, Dornsife Sch Publ Hlth, 3215 Market St Room 352, Philadelphia, PA 19104 USA.; Pintor, JK (corresponding author), Univ Calif Davis, Ctr Hlth & Environm, 1250 Old Davis Rd, Davis, CA 95616 USA.
EM jbp83@drexel.edu
FU Reiter Affiliated Companies LLC (RAC); NIOSH Grant [U54 OH007550];
   Agency for Healthcare Research and Quality (AHRQ) [T32 HS022236]
FX We extend our gratitude to study staff and participants without whom the
   pilot study and the work presented here would not have been possible.
   Reiter Affiliated Companies LLC (RAC) provided the majority of the grant
   funding for the pilot study, and study participants were all RAC
   workers. A contract was enacted between RAC and UC Davis, which ensured
   confidentiality for the participants and that the university retained
   the right to data and publishing independent to RAC. This study was
   supported by NIOSH Grant U54 OH007550 (the Western Center for
   Agricultural Health and Safety) and Agency for Healthcare Research and
   Quality (AHRQ) training Grant T32 HS022236. NIOSH, AHRQ, and RAC had no
   involvement in the study design, analysis and interpretation of data, or
   writing and submission of this manuscript. The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of NOISH, ARHQ, or RAC.
CR Abraído-Lanza AF, 2005, SOC SCI MED, V61, P1243, DOI 10.1016/j.socscimed.2005.01.016
   Adams EJ, 2003, J NUTR, V133, P1070, DOI 10.1093/jn/133.4.1070
   Ainsworth BE, 2011, MED SCI SPORT EXER, V43, P1575, DOI 10.1249/MSS.0b013e31821ece12
   Akresh Ilana Redstone, 2008, Biodemography Soc Biol, V54, P183, DOI 10.1080/19485565.2008.9989141
   Alderete E, 1999, J COMMUNITY PSYCHOL, V27, P457, DOI 10.1002/(SICI)1520-6629(199907)27:4<457::AID-JCOP7>3.0.CO;2-D
   Almeida J, 2016, SSM-POPUL HLTH, V2, P897, DOI 10.1016/j.ssmph.2016.11.003
   ANDRESEN EM, 1994, AM J PREV MED, V10, P77, DOI 10.1016/S0749-3797(18)30622-6
   [Anonymous], 2016, AD OB CAUS CONS
   [Anonymous], 2016, NAT AGR WORK SURV PU
   [Anonymous], YOUR HEART YOUR LIF
   Arcury TA, 2014, AM J IND MED, V57, P776, DOI 10.1002/ajim.22324
   Arcury TA, 2012, AM J IND MED, V55, P191, DOI 10.1002/ajim.22011
   Barcellos SH, 2012, HEALTH AFFAIR, V31, P2727, DOI 10.1377/hlthaff.2011.0973
   Block JP, 2009, AM J EPIDEMIOL, V70, P518
   Byrne SM, 2002, J PSYCHOSOM RES, V53, P1029, DOI 10.1016/S0022-3999(02)00487-7
   Capps Randolph., 2002, How Are Immigrants Faring After Welfare Reform? Preliminary Evidence from Los Angeles and New York City
   Davila EP, 2010, DIABETES CARE, V33, P2390, DOI 10.2337/dc10-0681
   DEPUE JD, 1995, OBES RES, V3, P241, DOI 10.1002/j.1550-8528.1995.tb00144.x
   Elfhag K, 2005, OBES REV, V6, P67, DOI 10.1111/j.1467-789X.2005.00170.x
   Fitzgerald N, 2011, ETHNIC DIS, V21, P328
   Goel MS, 2004, JAMA-J AM MED ASSOC, V292, P2860, DOI 10.1001/jama.292.23.2860
   Goodman D, 2013, J IMMIGR MINOR HEALT, V15, P93, DOI 10.1007/s10903-012-9717-0
   Grzywacz J.G., 2009, LATINO FARMWORKERS E, P153
   Grzywacz JG, 2006, HISPANIC J BEHAV SCI, V28, P404, DOI 10.1177/0739986306290645
   Hardy LJ, 2012, AM J PUBLIC HEALTH, V102, P1250, DOI 10.2105/AJPH.2011.300541
   Hiott AE, 2008, J RURAL HEALTH, V24, P32, DOI 10.1111/j.1748-0361.2008.00134.x
   Hovey J D, 2000, J Immigr Health, V2, P119, DOI 10.1023/A:1009556802759
   KAYMAN S, 1990, AM J CLIN NUTR, V52, P800, DOI 10.1093/ajcn/52.5.800
   Kraemer HC, 2002, ARCH GEN PSYCHIAT, V59, P877, DOI 10.1001/archpsyc.59.10.877
   Leigh JP, 2015, J AGROMEDICINE, V20, P409, DOI 10.1080/1059924X.2015.1074973
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Mabli James, 2013, Measuring the Effect of Supplemental Nutrition Assistance Program (SNAP) Participation on Food Security
   Marsh B, 2015, NEW SOLUT, V25, P313, DOI 10.1177/1048291115601020
   Medel-Herrero A, 2017, J IMMIGR MINOR HLTH
   Mitchell DC, 2015, J OCCUP ENVIRON MED, V57, P1039, DOI 10.1097/JOM.0000000000000535
   Moore CJ, 2012, J ACAD NUTR DIET, V112, P518, DOI 10.1016/j.jand.2011.12.001
   Mora DC, 2016, J AGROMEDICINE, V21, P327, DOI 10.1080/1059924X.2016.1211053
   Novak NL, 2017, INT J EPIDEMIOL
   Pan LP, 2012, J ACAD NUTR DIET, V112, P1403, DOI 10.1016/j.jand.2012.06.011
   Passel J.S., 2016, SIZE US UNAUTHORIZED
   Passel Jeffrey., 2009, PORTRAIT UNAUTHORIZE
   Philbin MM., 2017, Soc Sci Med
   Poss JE., 2003, Californian Journal of Health Promotion, V1, P138, DOI DOI 10.32398/cjhp.v1i2.436
   Pratt L., 2014, DEPRESSION US HOUSEH
   Pulgar CA, 2016, J IMMIGR MINOR HEALT, V18, P497, DOI 10.1007/s10903-015-0229-6
   Quandt SA, 2004, PUBLIC HEALTH REP, V119, P568, DOI 10.1016/j.phr.2004.09.006
   Quandt SA, 2015, NEW SOLUT, V25, P263, DOI 10.1177/1048291115601053
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Ramos AK, 2015, J IMMIGR MINOR HEALT, V17, P1627, DOI 10.1007/s10903-015-0201-5
   Reid A, 2016, AM J IND MED, V59, P644, DOI 10.1002/ajim.22613
   Rhodes SD, 2015, AM J PUBLIC HEALTH, V105, P329, DOI 10.2105/AJPH.2014.302218
   Roblyer MIZ, 2016, WOMEN HEALTH, V56, P177, DOI 10.1080/03630242.2015.1086464
   Rosado JI, 2013, AM J PREV MED, V44, pS274, DOI 10.1016/j.amepre.2012.11.019
   Rubin DB, 1996, J AM STAT ASSOC, V91, P473, DOI 10.1080/01621459.1996.10476908
   Siordia C., 2015, Global Journal of Biology, Agriculture, Health Sciences, V4, P118
   StataCorp, 2015, STATACORP STAT VERS
   Villarejo D, 2010, AM J IND MED, V53, P387, DOI 10.1002/ajim.20796
   Weigel M Margaret, 2007, J Immigr Minor Health, V9, P157, DOI 10.1007/s10903-006-9026-6
   Westenhoefer J, 2004, INT J OBESITY, V28, P334, DOI 10.1038/sj.ijo.0802530
NR 59
TC 3
Z9 4
U1 0
U2 14
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1557-1912
EI 1557-1920
J9 J IMMIGR MINOR HEALT
JI J. Immigr. Minor. Health
PD APR
PY 2019
VL 21
IS 2
BP 383
EP 392
DI 10.1007/s10903-018-0743-4
PG 10
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA HU6TG
UT WOS:000465413100021
PM 29737446
DA 2025-06-11
ER

PT J
AU Brailean, A
   Curtis, J
   Davis, K
   Dregan, A
   Hotopf, M
AF Brailean, Anamaria
   Curtis, Jessica
   Davis, Katrina
   Dregan, Alexandru
   Hotopf, Matthew
TI Characteristics, comorbidities, and correlates of atypical depression:
   evidence from the UK Biobank Mental Health Survey
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Adverse life events; atypical depression; cardiovascular disease;
   depression course; metabolic syndrome; obesity; psychiatric
   comorbidities; socioeconomic disadvantage; unhealthy lifestyle
ID MAJOR DEPRESSION; BIPOLAR-II; FEATURES; SYMPTOMS; VALIDATION; SUBTYPES;
   OBESITY; EPIDEMIOLOGY; OUTPATIENTS; PREVALENCE
AB Background Depression is a heterogeneous disorder with multiple aetiological pathways and multiple therapeutic targets. This study aims to determine whether atypical depression (AD) characterized by reversed neurovegetative symptoms is associated with a more pernicious course and a different sociodemographic, lifestyle, and comorbidity profile than nonatypical depression (nonAD). Methods Among 157 366 adults who completed the UK Biobank Mental Health Questionnaire (MHQ), N = 37 434 (24%) met the DSM-5 criteria for probable lifetime major depressive disorder (MDD) based on the Composite International Diagnostic Interview Short Form. Participants reporting both hypersomnia and weight gain were classified as AD cases (N = 2305), and the others as nonAD cases (N = 35 129). Logistic regression analyses were conducted to examine differences between AD and nonAD in depression features, sociodemographic and lifestyle factors, lifetime adversities, psychiatric and physical comorbidities. Results Persons with AD experienced an earlier age of depression onset, longer, more severe and recurrent episodes, and higher help-seeking rates than nonAD persons. AD was associated with female gender, unhealthy behaviours (smoking, social isolation, low physical activity), more lifetime deprivation and adversity, higher rates of comorbid psychiatric disorders, obesity, cardiovascular disease (CVD), and metabolic syndrome. Sensitivity analyses comparing AD persons with those having typical neurovegetative symptoms (hyposomnia and weight loss) revealed similar results. Conclusions These findings highlight the clinical and public health significance of AD as a chronic form of depression, associated with high comorbidity and lifetime adversity. Our findings have implications for predicting depression course and comorbidities, guiding research on aetiological mechanisms, planning service use and informing therapeutic approaches.
C1 [Brailean, Anamaria; Davis, Katrina; Dregan, Alexandru; Hotopf, Matthew] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, London, England.
   [Curtis, Jessica] Kings Coll London, Fac Life Sci & Med, London, England.
   [Davis, Katrina; Hotopf, Matthew] South London & Maudsley NHS Fdn Trust, London, England.
C3 University of London; King's College London; University of London;
   King's College London; South London & Maudsley NHS Trust
RP Brailean, A (corresponding author), Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, London, England.
EM anamaria@gmail.com
RI Hotopf, Matthew/E-4971-2010
OI Dregan, Alex/0000-0002-7620-4902; Hotopf, Matthew/0000-0002-3980-4466;
   Davis, Katrina/0000-0001-5945-4646
FU National Institute for Health Research (NIHR) Biomedical Research Centre
   at South London; Maudsley NHS Foundation Trust and King's College London
FX This paper represents independent research funded by the National
   Institute for Health Research (NIHR) Biomedical Research Centre at South
   London and Maudsley NHS Foundation Trust and King's College London. The
   views expressed are those of the authors and not necessarily those of
   the NHS, the NIHR or the Department of Health and Social Care.
CR Agosti V, 2001, J AFFECT DISORDERS, V65, P75, DOI 10.1016/S0165-0327(00)00251-2
   Akiskal HS, 2005, J AFFECT DISORDERS, V84, P209, DOI 10.1016/j.jad.2004.05.004
   Angst J, 2007, ACTA PSYCHIAT SCAND, V115, P72, DOI 10.1111/j.1600-0447.2007.00965.x
   Angst J, 2006, EUR ARCH PSY CLIN N, V256, P44, DOI 10.1007/s00406-005-0600-z
   Angst J, 2002, J AFFECT DISORDERS, V72, P125, DOI 10.1016/S0165-0327(02)00169-6
   Association AP, 2013, Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
   Benazzi F, 2002, EUR ARCH PSY CLIN N, V252, P288, DOI 10.1007/s00406-002-0395-0
   Benazzi F, 2002, EUR ARCH PSY CLIN N, V252, P135, DOI 10.1007/s00406-002-0373-6
   Blanco C, 2012, J CLIN PSYCHIAT, V73, P224, DOI 10.4088/JCP.10m06227
   Bot M, 2015, BIOL PSYCHIAT, V77, DOI 10.1016/j.biopsych.2015.10.023
   Case SM, 2018, DEPRESS ANXIETY, V35, P10, DOI 10.1002/da.22666
   Davidson JRT, 2007, J CLIN PSYCHIAT, V68, P10
   Davis KAS, 2018, BJPSYCH OPEN, V4, P83, DOI 10.1192/bjo.2018.12
   Fournier JC, 2013, BEHAV RES THER, V51, P392, DOI 10.1016/j.brat.2013.03.010
   Fry A, 2017, AM J EPIDEMIOL, V186, P1026, DOI 10.1093/aje/kwx246
   Glaus J, 2013, ACTA PSYCHIAT SCAND, V128, P282, DOI 10.1111/acps.12057
   Harald B, 2012, J AFFECT DISORDERS, V139, P126, DOI 10.1016/j.jad.2011.07.015
   HORWATH E, 1992, J AFFECT DISORDERS, V26, P117, DOI 10.1016/0165-0327(92)90043-6
   Jarrett RB, 2000, PSYCHOTHER PSYCHOSOM, V69, P232, DOI 10.1159/000012401
   Kessler RC, 2004, INT J METH PSYCH RES, V13, P93, DOI 10.1002/mpr.168
   Korte SM, 2015, EUR J PHARMACOL, V753, P88, DOI 10.1016/j.ejphar.2014.11.045
   Koyuncu A, 2015, PSYCHIAT RES, V225, P79, DOI 10.1016/j.psychres.2014.10.014
   Lamers F, 2016, BRIT J PSYCHIAT, V208, P62, DOI 10.1192/bjp.bp.114.153098
   Lamers F, 2013, MOL PSYCHIATR, V18, P692, DOI 10.1038/mp.2012.144
   Lamers F, 2016, J AFFECT DISORDERS, V204, P241, DOI 10.1016/j.jad.2016.06.040
   Lasserre AM, 2014, JAMA PSYCHIAT, V71, P880, DOI 10.1001/jamapsychiatry.2014.411
   Lee S, 2009, AUST NZ J PSYCHIAT, V43, P1147, DOI 10.3109/00048670903279895
   Levinson D, 2017, EUR NEUROPSYCHOPHARM, V27, pS448, DOI 10.1016/j.euroneuro.2016.09.514
   Levitan RD, 1997, AM J PSYCHIAT, V154, P934
   Lojko D, 2017, NEUROPSYCH DIS TREAT, V13, P2447, DOI 10.2147/NDT.S147317
   Matza LS, 2003, ARCH GEN PSYCHIAT, V60, P817, DOI 10.1001/archpsyc.60.8.817
   McGinn LK, 2005, COMPR PSYCHIAT, V46, P428, DOI 10.1016/j.comppsych.2005.03.002
   Milaneschi Y, 2016, MOL PSYCHIATR, V21, P516, DOI 10.1038/mp.2015.86
   Milaneschi Y, 2017, JAMA PSYCHIAT, V74, P1214, DOI 10.1001/jamapsychiatry.2017.3016
   Nierenberg AA, 1998, J CLIN PSYCHIAT, V59, P5
   Niranjan A, 2012, GEN HOSP PSYCHIAT, V34, P254, DOI 10.1016/j.genhosppsych.2012.01.018
   Novick JS, 2005, J CLIN PSYCHIAT, V66, P1002, DOI 10.4088/JCP.v66n0807
   Parker GB, 2007, J CLIN PSYCHIAT, V68, P18
   Patten S B, 1997, Chronic Dis Can, V18, P109
   Perugi G, 1998, COMPR PSYCHIAT, V39, P63, DOI 10.1016/S0010-440X(98)90080-3
   Posternak MA, 2002, ARCH GEN PSYCHIAT, V59, P70, DOI 10.1001/archpsyc.59.1.70
   Rethorst CD, 2016, J AFFECT DISORDERS, V200, P156, DOI 10.1016/j.jad.2016.01.052
   STEWART JW, 1993, PSYCHIAT CLIN N AM, V16, P479
   Sudlow C, 2015, PLOS MED, V12, DOI 10.1371/journal.pmed.1001779
   Sullivan PF, 1998, AM J PSYCHIAT, V155, P1398, DOI 10.1176/ajp.155.10.1398
   Sunderland M, 2011, SOC PSYCH PSYCH EPID, V46, P775, DOI 10.1007/s00127-010-0247-6
   Thase ME, 2007, J CLIN PSYCHIAT, V68, P11
   Ul-Haq Z, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-1197
   Withers AC, 2013, J CLIN PSYCHIAT, V74, P500, DOI 10.4088/JCP.12m07870
NR 49
TC 59
Z9 62
U1 2
U2 34
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD MAY
PY 2020
VL 50
IS 7
BP 1129
EP 1138
AR PII S0033291719001004
DI 10.1017/S0033291719001004
PG 10
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA LR2FD
UT WOS:000535510400008
PM 31044683
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Benson, S
   Arck, PC
   Tan, S
   Mann, K
   Hahn, S
   Janssen, OE
   Schedlowski, M
   Elsenbruch, S
AF Benson, S.
   Arck, P. C.
   Tan, S.
   Mann, K.
   Hahn, S.
   Janssen, O. E.
   Schedlowski, M.
   Elsenbruch, S.
TI Effects of obesity on neuroendocrine, cardiovascular, and immune cell
   responses to acute psychosocial stress in premenopausal women
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Obesity; Psychological stress; IL-6; Cortisol; Leukocytes; Immune system
ID CORONARY-HEART-DISEASE; POLYCYSTIC-OVARY-SYNDROME; PUBLIC SPEAKING
   STRESS; PITUITARY-ADRENAL AXIS; C-REACTIVE PROTEIN; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; DIABETES-MELLITUS; BODY-MASS; INTERLEUKIN-6
AB Objective: To analyze the neuroendocrine and immune cell responses to acute psychosocial stress in obese compared to non-obese premenopausal women.
   Methods: N = 15 obese (BMI >= 30) and N = 24 (BMI < 30) non-obese premenopausal women underwent public speaking stress. State anxiety, ACTH, cortisol, and the redistribution of immune cells were measured before, during, and 10 and 45 min after public speaking. Serum hsCRP and serum IL-6 levels were analyzed before, and IL-6 additionally 45 min after stress.
   Results: In response to public speaking stress, both groups showed significant but comparable increases in state anxiety, plasma ACTH, and blood pressure (all p < 0.01; time effects). The cortisol stress response was significantly enhanced in obese women (p < 0.05; interaction effect). In addition, heart rate and diastolic blood pressure were significantly higher in obese women 10 min following stress (p < 0.05, t-tests). Public speaking stress led to a significant increase in IL-6 concentrations (p < 0.001; time effect), and obese women displayed higher IL-6 levels both pre- and post-stress (p < 0.05; group effect; between-group t-tests: pre-stress p < 0.05; post-stress p < 0.01). Baseline numbers of circulating leukocytes, granulocytes, CD3+ cells and hsCRP concentration were significantly higher in obese women (between-group t-tests: all p < 0.05, but the groups did not differ in the stress-induced redistribution of circulating leukocyte subpopulations.
   Conclusions: Our data reveal a strong association of obesity with chronic low-grade inflammation in premenopausal women. This pro-inflammatory state, together with altered neuroendocrine and cardiovascular stress responsiveness, may conceivably constitute one of the mechanisms linking psychological stress and the long-term health risks associated with obesity. (C) 2008 Elsevier Ltd. All rights reserved.
C1 [Benson, S.; Schedlowski, M.; Elsenbruch, S.] Univ Duisburg Essen, Univ Clin Essen, Dept Med Psychol & Behav Immunobiol, D-45122 Essen, Germany.
   [Arck, P. C.] Charite Univ Med Berlin, Ctr Internal Med & Dermatol, Clin Internal Med & Psychosomat, Berlin, Germany.
   [Tan, S.; Mann, K.] Univ Duisburg Essen, Univ Clin Essen, Dept Med, Div Endocrinol, D-45122 Essen, Germany.
   [Hahn, S.] Endokrinol Praxis, Wuppertal, Germany.
   [Janssen, O. E.] Ctr Endocrine & Metab Dis, Hamburg, Germany.
C3 University of Duisburg Essen; Berlin Institute of Health; Free
   University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; University of Duisburg Essen
RP Elsenbruch, S (corresponding author), Univ Duisburg Essen, Univ Clin Essen, Dept Med Psychol & Behav Immunobiol, Hufelandstr 55, D-45122 Essen, Germany.
EM sigrid.eisenbruch@uk-essen.de
RI Tan, Susanne/GLN-3251-2022; Schedlowski, Manfred/GLU-7519-2022; Arck,
   Petra/D-7094-2013; Benson, Sven/I-1981-2014
OI Reger-Tan, Susanne/0000-0003-2692-8643; Elsenbruch,
   Sigrid/0000-0002-6528-2665; Benson, Sven/0000-0002-4487-4258; Arck,
   Petra Clara/0000-0002-2932-926X
FU Lienert-Stiftung
FX The authors would like to express their gratitude to Petra Busse, Evetin
   Hagen, Andrea Jaeger, and Natalie Riemenschneider for excellent
   technical support. Sven Benson was supported by a stipend from the
   Lienert-Stiftung.
CR Alevizaki M, 2007, METABOLISM, V56, P222, DOI 10.1016/j.metabol.2006.09.017
   BJOERNTORP P, 2001, OBES REV, V2, P73
   Black PH, 2006, MED HYPOTHESES, V67, P879, DOI 10.1016/j.mehy.2006.04.008
   Black PH, 2003, BRAIN BEHAV IMMUN, V17, P350, DOI 10.1016/S0889-1591(03)00048-5
   Bray GA, 2004, J CLIN ENDOCR METAB, V89, P2583, DOI 10.1210/jc.2004-0535
   Brydon L, 2008, INT J OBESITY, V32, P443, DOI 10.1038/sj.ijo.0803767
   Brydon L, 2005, J HYPERTENS, V23, P1001, DOI 10.1097/01.hjh.0000166841.57474.d0
   Bullinger M., 1998, SF-36 Fragebogen zum Gesundheitszustand - HandanweisungAufl
   DEROGATIS LR, 1976, BRIT J PSYCHIAT, V128, P280, DOI 10.1192/bjp.128.3.280
   Donato KA, 1998, ARCH INTERN MED, V158, P1855, DOI 10.1001/archinte.158.17.1855
   Elsenbruch S, 2006, AM J GASTROENTEROL, V101, P2300, DOI 10.1111/j.1572-0241.2006.00837.x
   Epel ES, 2000, PSYCHOSOM MED, V62, P623, DOI 10.1097/00006842-200009000-00005
   Fernández-Real JM, 2003, ENDOCR REV, V24, P278, DOI 10.1210/er.2002-0010
   Flegal KM, 2007, JAMA-J AM MED ASSOC, V298, P2028, DOI 10.1001/jama.298.17.2028
   Fliege H, 2005, PSYCHOSOM MED, V67, P78, DOI 10.1097/01.psy.0000151491.80178.78
   Fry J, 2005, P NUTR SOC, V64, P359, DOI 10.1079/PNS2005443
   Hautzinger M, 1995, Beck-Depressions-Inventar (BDI)
   HEINRICH PC, 1990, BIOCHEM J, V265, P621, DOI 10.1042/bj2650621
   Koertge J, 2002, PSYCHONEUROENDOCRINO, V27, P893, DOI 10.1016/S0306-4530(02)00002-1
   Lahiri K, 2007, CLIN RES CARDIOL, V96, P365, DOI 10.1007/s00392-007-0512-1
   Langhorst J, 2007, PSYCHONEUROENDOCRINO, V32, P1086, DOI 10.1016/j.psyneuen.2007.09.003
   Lucas A, 2006, BRAIN BEHAV IMMUN, V20, P49, DOI 10.1016/j.bbi.2005.03.009
   MANSON JE, 1995, NEW ENGL J MED, V333, P677, DOI 10.1056/NEJM199509143331101
   MENSINK GB, 2005, GESUNDHEITSSCHUTZ, V48, P1348
   Miller GE, 2002, AM J CARDIOL, V90, P1279, DOI 10.1016/S0002-9149(02)02863-1
   Ogden CL, 2006, JAMA-J AM MED ASSOC, V295, P1549, DOI 10.1001/jama.295.13.1549
   Pace TWW, 2006, AM J PSYCHIAT, V163, P1630, DOI 10.1176/appi.ajp.163.9.1630
   Pasquali R, 2006, BJOG-INT J OBSTET GY, V113, P1148, DOI 10.1111/j.1471-0528.2006.00990.x
   Pasquali R, 2002, J CLIN ENDOCR METAB, V87, P166, DOI 10.1210/jc.87.1.166
   Pasquali R, 2006, ANN NY ACAD SCI, V1083, P111, DOI 10.1196/annals.1367.009
   Petry NM, 2008, PSYCHOSOM MED, V70, P288, DOI 10.1097/PSY.0b013e3181651651
   Player MS, 2007, ANN FAM MED, V5, P403, DOI 10.1370/afm.738
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Ridker PM, 2000, NEW ENGL J MED, V342, P836, DOI 10.1056/NEJM200003233421202
   Rosmond R, 2005, PSYCHONEUROENDOCRINO, V30, P1, DOI 10.1016/j.psyneuen.2004.05.007
   Rozanski A, 1999, CIRCULATION, V99, P2192, DOI 10.1161/01.CIR.99.16.2192
   Spielberger C. D., 1970, MANUAL STATE TRAIT A
   Steptoe A, 2005, INT J OBESITY, V29, P1329, DOI 10.1038/sj.ijo.0803011
   Steptoe A, 2007, BRAIN BEHAV IMMUN, V21, P901, DOI 10.1016/j.bbi.2007.03.011
   Stunkard AJ, 2003, BIOL PSYCHIAT, V54, P330, DOI 10.1016/S0006-3223(03)00608-5
   Tichomirowa MA, 2005, J ENDOCRINOL INVEST, V28, P89, DOI 10.1007/BF03345535
   Tilg H, 2006, NAT REV IMMUNOL, V6, P772, DOI 10.1038/nri1937
   Vgontzas AN, 2006, METABOLISM, V55, P1076, DOI 10.1016/j.metabol.2006.04.002
   Vicennati V, 2000, J CLIN ENDOCR METAB, V85, P4093, DOI 10.1210/jc.85.11.4093
   von Känel R, 2005, CLIN SCI, V109, P61, DOI 10.1042/CS20040359
   Yudkin JS, 2000, ATHEROSCLEROSIS, V148, P209, DOI 10.1016/S0021-9150(99)00463-3
   Zellner K, 2007, ECON HUM BIOL, V5, P426, DOI 10.1016/j.ehb.2007.07.002
NR 47
TC 45
Z9 56
U1 0
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD FEB
PY 2009
VL 34
IS 2
BP 181
EP 189
DI 10.1016/j.psyneuen.2008.08.019
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 408JM
UT WOS:000263431300003
PM 18838227
DA 2025-06-11
ER

PT J
AU Chandrasekaran, B
   Bairapareddy, KC
   Rao, CR
AF Chandrasekaran, Baskaran
   Bairapareddy, Kalyana Chakravarthy
   Rao, Chythra R.
TI Resistance Exercise Training on Musculoskeletal, Metabolic and
   Psychological Health in Sedentary Office Workers - Systematic Review and
   Meta-analysis
SO JOURNAL OF OCCUPATIONAL REHABILITATION
LA English
DT Review; Early Access
DE Strength training; Cardiometabolic risk; Pain; Office worker; Sedentary;
   Worker
ID PHYSICAL-ACTIVITY INTERVENTIONS; CHRONIC NECK PAIN; WORKPLACE;
   BEHAVIORS; TIME
AB Purpose To consolidate the emerging evidence on the effectiveness of resistance training (RT) in reducing the health risks among sedentary office workers. Methods Four electronic databases were searched for evidence from its inception till september 20, 2024. Studies were included if they examined any form of RT program targeting musculoskeletal, metabolic, or psychological health outcomes in office workers aged 18 years or older using PICOS criteria (Population - office workers, Intervention - RT program, Comparison - placebo or sham control and Outcomes - musculoskeletal, cardiometabolic and psychological health variables). Two reviewers independently screened the studies for risk of bias and assessed the certainty of the evidence. Results Out of 60 identified studies, 17 studies were eligible for narrative synthesis, and 16 were included in the meta-analysis. Modest reductions in neck (SMD = -1.76, I-2 = 88%, p < 0.00001) and shoulder discomfort (SMD = -13.29, I-2 = 91%, p < 0.00001), while marginal improvement in shoulder (SMD = 4.13, I-2 = 99%, p = 0.03) and neck extensor muscle strength (SMD = 9.07, I-2 = 9%, p < 0.00001). The cardiometabolic and mental health risk markers remain unaltered. High uncertainty of evidence was observed due to high heterogeneity, risk of bias, inconsistency and publication bias. Conclusion Limited evidence demonstrate supervised RT programs of any dose has a potential to improve muscular strength and discomfort while potential cardiometabolic and mental health risk outcomes remain unaltered. However, more high-quality research trials are needed to understand the effects of RT on health benefits.
C1 [Chandrasekaran, Baskaran] Manipal Acad Higher Educ, Manipal Coll Hlth Profess, Dept Exercise & Sports Sci, Manipal 576104, Karnataka, India.
   [Bairapareddy, Kalyana Chakravarthy] Univ Sharjah, Coll Hlth Sci, Dept Physiotherapy, Sharjah, U Arab Emirates.
   [Rao, Chythra R.] Manipal Acad Higher Educ, Kasturba Med Coll, Dept Community Med, Manipal 576104, Karnataka, India.
C3 Manipal Academy of Higher Education (MAHE); University of Sharjah;
   Manipal Academy of Higher Education (MAHE); Kasturba Medical College,
   Manipal
RP Chandrasekaran, B (corresponding author), Manipal Acad Higher Educ, Manipal Coll Hlth Profess, Dept Exercise & Sports Sci, Manipal 576104, Karnataka, India.
EM baskaran.c@manipal.edu; cdpraj@yahoo.com; chythra.raj@manipal.edu
RI Arumugam, Ashokan/ABA-4953-2022; Rao, Dr. Chythra R/D-5449-2016;
   Chandrasekaran, Baskaran/R-2824-2016
OI Arumugam, Ashokan/0000-0001-5795-3812; Rao, Dr. Chythra
   R/0000-0002-4016-2683; Chandrasekaran, Baskaran/0000-0003-1439-9158
FU Manipal Academy of Higher Education, Manipal; Health Sciences Library,
   Manipal Academy of Higher Education
FX Authors wish to thank the Health Sciences Library, Manipal Academy of
   Higher Education for the support for search strategy and trial search in
   four databases.
CR Abdin S, 2018, PUBLIC HEALTH, V160, P70, DOI 10.1016/j.puhe.2018.03.029
   Andersen CH, 2012, BRIT J SPORT MED, V46, P1004, DOI 10.1136/bjsports-2011-090813
   Andersen LL, 2008, MED SCI SPORT EXER, V40, P983, DOI 10.1249/MSS.0b013e3181676640
   Bell JA, 2009, J OCCUP REHABIL, V19, P8, DOI 10.1007/s10926-009-9164-5
   Brandt T, 2024, FRONT PUBLIC HEALTH, V12, DOI 10.3389/fpubh.2024.1347825
   Brierley ML, 2019, SPORTS MED, V49, P1739, DOI 10.1007/s40279-019-01168-9
   Buffey AJ, 2022, SPORTS MED, V52, P1765, DOI 10.1007/s40279-022-01649-4
   Burn NL, 2019, SPORTS MED, V49, P1255, DOI 10.1007/s40279-019-01125-6
   Chen XQ, 2018, PHYS THER, V98, P40, DOI 10.1093/ptj/pzx101
   Chu AHY, 2016, OBES REV, V17, P467, DOI 10.1111/obr.12388
   Chu AHY, 2014, OCCUP MED-OXFORD, V64, P235, DOI 10.1093/occmed/kqu045
   Ciolac EG, 2016, SPORTS MED, V46, P1239, DOI 10.1007/s40279-016-0507-z
   Dalager T, 2023, PHYS THER, V103, DOI 10.1093/ptj/pzac166
   Dalton JE, 2016, ANESTH ANALG, V123, P812, DOI 10.1213/ANE.0000000000001596
   Deeks JJ, 2011, Cochrane Handbook for Systematic Reviews of Interventions, P241
   Depreli O, 2024, INT J OCCUP SAF ERGO, V30, P599, DOI 10.1080/10803548.2024.2326358
   Frutiger M, 2021, PAIN PRACT, V21, P100, DOI 10.1111/papr.12940
   Gobbo Stefano, 2019, J Funct Morphol Kinesiol, V4, DOI 10.3390/jfmk4030043
   Granacher U, 2011, INT J SPORTS MED, V32, P35, DOI 10.1055/s-0030-1267214
   Heredia-Rizo AM, 2019, CLIN J PAIN, V35, P65, DOI 10.1097/AJP.0000000000000656
   Ho SY, 2024, PEERJ, V12, DOI 10.7717/peerj.17140
   Jones LB, 2024, APPL ERGON, V117, DOI 10.1016/j.apergo.2023.104216
   Joyce S, 2016, PSYCHOL MED, V46, P683, DOI 10.1017/S0033291715002408
   Karatrantou K, 2023, SPORTS, V11, DOI 10.3390/sports11040084
   Koohsari MJ, 2021, J OCCUP ENVIRON MED, V63, pE685, DOI 10.1097/JOM.0000000000002333
   Kumar S, 2001, ERGONOMICS, V44, P17, DOI 10.1080/00140130150203866
   Lidegaard M, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/262386
   Louw S, 2017, SOUTH AFR J PHYSIOTH, V73, DOI 10.4102/sajp.v73i1.392
   Marin-Farrona M, 2023, SYST REV-LONDON, V12, DOI 10.1186/s13643-023-02258-6
   Martin A, 2009, SCAND J WORK ENV HEA, V35, P7, DOI 10.5271/sjweh.1295
   Martinez R, 2020, LANCET GLOB HEALTH, V8, pE511, DOI 10.1016/S2214-109X(20)30035-8
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Mulchandani R, 2019, INT J BEHAV NUTR PHY, V16, DOI 10.1186/s12966-019-0896-0
   Mulla DM, 2018, J OCCUP ENVIRON MED, V60, P1005, DOI 10.1097/JOM.0000000000001408
   Neuhaus M, 2014, OBES REV, V15, P822, DOI 10.1111/obr.12201
   Nguyen TM, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18073791
   Nikander R, 2006, MED SCI SPORT EXER, V38, P2068, DOI 10.1249/01.mss.0000229105.16274.4b
   Nuzzo JL, 2024, SPORTS MED, V54, P1139, DOI 10.1007/s40279-024-02009-0
   Owen N, 2010, MAYO CLIN PROC, V85, P1138, DOI 10.4065/mcp.2010.0444
   Oye-Somefun A, 2021, BMC PUBLIC HEALTH, V21, DOI 10.1186/s12889-021-12094-9
   Page MJ., 2021, PRISMA: BMJ, V134, P178, DOI [DOI 10.1016/J.JCLINEPI.2021.03.001, 10.1016/j.jclinepi.2021.03.001, DOI 10.1136/BMJ.N71]
   Paluch AE, 2024, CIRCULATION, V149, pE217, DOI 10.1161/CIR.0000000000001189
   Parés-Salomón I, 2024, INT J BEHAV NUTR PHY, V21, DOI 10.1186/s12966-024-01595-6
   Pedersen MT, 2009, J OCCUP ENVIRON MED, V51, P759, DOI 10.1097/JOM.0b013e3181a8663a
   Qi ML, 2019, TOP GERIATR REHABIL, V35, P255, DOI 10.1097/TGR.0000000000000244
   Rasmussen-Barr E, 2023, BMC MUSCULOSKEL DIS, V24, DOI 10.1186/s12891-023-06930-9
   Reed JL, 2017, CIRC-CARDIOVASC QUAL, V10, DOI 10.1161/CIRCOUTCOMES.116.003516
   Rogers EM, 2024, EXP PHYSIOL, DOI 10.1113/EP091535
   Rogers EM, 2024, WORKPLACE HEALTH SAF, V72, P234, DOI 10.1177/21650799231215814
   Saeterbakken AH, 2020, BMC SPORTS SCI MED R, V12, DOI 10.1186/s13102-020-0158-0
   Sarabon N, 2020, LIFE-BASEL, V10, DOI 10.3390/life10110284
   Sarveswaran G, 2020, DIABETES METAB SYND, V14, P1005, DOI 10.1016/j.dsx.2020.05.042
   Silva H, 2025, HUM FACTORS, V67, P695, DOI 10.1177/00187208241305591
   Taylor WC, 2023, HUM FACTORS, V65, P891, DOI 10.1177/00187208211034271
   Tremblay MS, 2017, INT J BEHAV NUTR PHY, V14, DOI 10.1186/s12966-017-0525-8
   Uddin R, 2020, PREV MED, V131, DOI 10.1016/j.ypmed.2019.105955
   Wang C, 2024, PUBLIC HEALTH, V230, P45, DOI 10.1016/j.puhe.2024.02.013
   Ylinen J, 2003, JAMA-J AM MED ASSOC, V289, P2509, DOI 10.1001/jama.289.19.2509
   Zhou LY, 2023, JMIR PUBLIC HLTH SUR, V9, DOI 10.2196/44745
NR 59
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1053-0487
EI 1573-3688
J9 J OCCUP REHABIL
JI J. Occup. Rehabil.
PD 2025 FEB 14
PY 2025
DI 10.1007/s10926-025-10273-8
EA FEB 2025
PG 20
WC Rehabilitation; Social Issues
WE Social Science Citation Index (SSCI)
SC Rehabilitation; Social Issues
GA X0B9U
UT WOS:001422124100001
PM 39953203
OA hybrid
DA 2025-06-11
ER

PT J
AU Kim, HJ
   Kim, BS
   Kim, DW
   Shin, JH
AF Kim, Hyun-Jin
   Kim, Byung Sik
   Kim, Dong Wook
   Shin, Jeong-Hun
TI Estimated pulse wave velocity as a forefront indicator of developing
   metabolic syndrome in Korean adults
SO KOREAN JOURNAL OF INTERNAL MEDICINE
LA English
DT Article
DE Metabolic syndrome; Pulse wave analysis; Population; Arterial stiffness;
   Blood pressure
ID ARTERIAL STIFFNESS; OXIDATIVE STRESS; INFLAMMATION; HYPERTENSION;
   ASSOCIATION; MANAGEMENT; AGE
AB Background/Aims: The predictive value of the estimated pulse wave velocity (ePWV) for the development of metabolic syndrome has not yet been extensively explored. This study aimed to fill this gap by evaluating ePWV as a potential predictor of metabolic syndrome development in middle-aged Korean adults. Methods: Using prospective data obtained from the Ansan-Ansung cohort database, participants without metabolic syndrome at baseline were studied. ePWV was calculated using specific equations based on age and blood pressure. The primary outcome was the incidence of metabolic syndrome during a median follow-up period of 187 months. Results: Among the 6,186 participants, 2,726 (44.1%) developed metabolic syndrome during the follow-up period. ePWV values were categorized into tertiles to assess their predictive value for the development of metabolic syndrome. An ePWV cut-off of 7.407 m/s was identified as a predictor of metabolic syndrome development, with a sensitivity of 0.743 and a specificity of 0.464. Participants exceeding this cut-off, especially those in the third tertile (8.77-14.63 m/s), had a notably higher risk of developing metabolic syndrome. Specifically, the third tertile exhibited a 52.8% cumulative incidence compared with 30.8% in the first tertile. After adjustments, those in the third tertile faced a 1.530 -fold increased risk of metabolic syndrome (95% confidence interval, 1.330-1.761). Conclusions: ePWV is a significant predictor of the development of metabolic syndrome. This finding underscores the potential of ePWV as a cardiometabolic risk assessment tool and can thus provide useful information for primary prevention strategies.
C1 [Kim, Hyun-Jin; Kim, Byung Sik; Shin, Jeong-Hun] Hanyang Univ, Coll Med, Dept Internal Med, Div Cardiol,Guri Hosp, 153 Gyeongchun Ro, Guri 11923, South Korea.
   [Kim, Dong Wook] Harvard Med Sch, Brigham & Womens Hosp, Ctr Weight Management & Wellness, Div Endocrinol Diabet & Hypertens, Boston, MA USA.
   [Shin, Jeong-Hun] Hanyang Univ, Hanyang Univ Guri Hosp, Div Gastroenterol & Hepatol, Dept Internal Med,Coll Med, 153 Gyeongchun Ro, Guri 11923, South Korea.
C3 Hanyang University; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard Medical School; Hanyang
   University
RP Shin, JH (corresponding author), Hanyang Univ, Coll Med, Dept Internal Med, Div Cardiol,Guri Hosp, 153 Gyeongchun Ro, Guri 11923, South Korea.; Shin, JH (corresponding author), Hanyang Univ, Hanyang Univ Guri Hosp, Div Gastroenterol & Hepatol, Dept Internal Med,Coll Med, 153 Gyeongchun Ro, Guri 11923, South Korea.
EM cardio.hyapex@gmail.com
RI Kim, Dahee/IAM-6955-2023; Kim, Hyun-Jin/AAJ-2905-2021; Shin,
   Jeong/O-1273-2019; Shin, Jeong Hun/T-3322-2017
OI Shin, Jeong Hun/0000-0002-6718-9763
FU Korean Society of Cardiometabolic Syndrome
FX The authors thank the Korean Society of Cardiometabolic Syndrome for
   providing funding for this online survey.
CR Agbaje AO, 2022, HYPERTENSION, V79, P667, DOI 10.1161/HYPERTENSIONAHA.121.18754
   Anderson TJ, 2006, CAN J CARDIOL, V22, p72B, DOI 10.1016/S0828-282X(06)70990-4
   Chae J, 2021, DIABETES METAB J, V45, P880, DOI 10.4093/dmj.2020.0185
   Cohen JB, 2022, CIRC RES, V131, P545, DOI 10.1161/CIRCRESAHA.122.320796
   Cons N C, 1967, J Public Health Dent, V27, P123, DOI 10.1111/j.1752-7325.1967.tb01391.x
   Dumor K, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0867-x
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Greve SV, 2016, J HYPERTENS, V34, P2410, DOI 10.1097/HJH.0000000000001083
   Greve SV, 2016, J HYPERTENS, V34, P1279, DOI 10.1097/HJH.0000000000000935
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Guzik TJ, 2017, HYPERTENSION, V70, P660, DOI 10.1161/HYPERTENSIONAHA.117.07802
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Huang HM, 2023, FRONT CARDIOVASC MED, V10, DOI 10.3389/fcvm.2023.1140160
   Huh JH, 2021, Cardiometab Syndr J, V1, P125, DOI DOI 10.51789/CMSJ.2021.1.E15
   Kim BY, 2021, J OBES METAB SYNDR, V30, P81, DOI 10.7570/jomes21022
   Kim BS, 2022, J PERS MED, V12, DOI 10.3390/jpm12101611
   Kim Hack-Lyoung, 2019, Front Cardiovasc Med, V6, P41, DOI 10.3389/fcvm.2019.00041
   Kim HJ, 2024, DIABETES METAB J, V48, DOI 10.4093/dmj.2023.0197
   Kim Y, 2017, INT J EPIDEMIOL, V46, DOI 10.1093/ije/dyv316
   Lee GP, 2022, REV CARDIOVASC MED, V23, DOI 10.31083/j.rcm2301006
   Li DD, 2023, DIABETOL METAB SYNDR, V15, DOI 10.1186/s13098-023-01011-2
   Mancia G, 2007, EUR HEART J, V28, P1462, DOI 10.1093/eurheartj/ehm236
   Sabio JM, 2009, J RHEUMATOL, V36, P2204, DOI 10.3899/jrheum.081253
   Mattace-Raso FUS, 2010, EUR HEART J, V31, P2338, DOI 10.1093/eurheartj/ehq165
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   Nilsson PM, 2019, EUR J PREV CARDIOL, V26, P33, DOI 10.1177/2047487319886404
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Park JB, 2023, PULSE, V11, P1, DOI 10.1159/000530616
   Park JB, 2022, PULSE, V10, P1, DOI 10.1159/000528208
   Ranasinghe P, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4041-1
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sequí-Domínguez I, 2020, J CLIN MED, V9, DOI 10.3390/jcm9072080
   Starzak M, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph191610368
   Topouchian J, 2018, J HYPERTENS, V36, P824, DOI 10.1097/HJH.0000000000001631
   van Bussel BC, 2011, HYPERTENSION, V58, P588, DOI 10.1161/HYPERTENSIONAHA.111.174557
   Vianna CA, 2019, NUTRITION, V61, P38, DOI 10.1016/j.nut.2018.09.037
   Vlachopoulos C, 2019, JAMA NETW OPEN, V2, DOI 10.1001/jamanetworkopen.2019.12831
   Xu XY, 2022, BMJ OPEN, V12, DOI 10.1136/bmjopen-2021-052457
   Yang H, 2019, J CLIN HYPERTENS, V21, P1379, DOI 10.1111/jch.13659
   Zheng MY, 2020, CIRC RES, V127, P1491, DOI 10.1161/CIRCRESAHA.120.317950
NR 41
TC 0
Z9 0
U1 1
U2 4
PU KOREAN ASSOC INTERNAL MEDICINE
PI SEOUL
PA 101-2501 LOTTE CASTLE PRESIDENT, 109 MAPO-DAERO, MAPO-GU, SEOUL, SOUTH
   KOREA
SN 1226-3303
EI 2005-6648
J9 KOREAN J INTERN MED
JI Korean J. Intern. Med.
PD JUL
PY 2024
VL 39
IS 4
DI 10.3904/kjim.2024.015
EA JUN 2024
PG 17
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA YB0K3
UT WOS:001252898100001
PM 38910511
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Supriya, R
   Tam, BT
   Yu, AP
   Lee, PH
   Lai, CW
   Cheng, KK
   Yau, SY
   Chan, LW
   Yung, BY
   Sheridan, S
   Siu, PM
AF Supriya, Rashmi
   Tam, Bjorn T.
   Yu, Angus P.
   Lee, Paul H.
   Lai, Christopher W.
   Cheng, Kenneth K.
   Yau, Sonata Y.
   Chan, Lawrence W.
   Yung, Benjamin Y.
   Sheridan, Sinead
   Siu, Parco M.
TI Adipokines demonstrate the interacting influence of central obesity with
   other cardiometabolic risk factors of metabolic syndrome in Hong Kong
   Chinese adults
SO PLOS ONE
LA English
DT Article
ID NECROSIS-FACTOR-ALPHA; LOW HDL CHOLESTEROL; INSULIN-RESISTANCE;
   ADIPOSE-TISSUE; FOLLOW-UP; SYSTEMIC INFLAMMATION; NUCLEAR RECEPTORS;
   OXIDATIVE STRESS; BLOOD-PRESSURE; NORMAL-WEIGHT
AB Objective
   Metabolic syndrome (MetS) or prediabetes is a complex disorder that is defined by a clustering of cardiometabolic risk factors, including obesity, hypertriglyceridemia, reduced high-density lipoprotein (HDL) cholesterol, hypertension, and insulin resistance. Among cardiometabolic risk factors, central obesity plays a key role in the development of MetS through alterations in the secretion of adipokines and interacts with other MetS risk factors to unfavorably influence overall cardiometabolic risk. Obesity has grasped epidemic proportions in Asia, which has the highest number of people with diabetes in the world. But, the importance of central obesity in the clustering of all four MetS risk factors or vice versa in predicting severity of MetS has not yet been investigated in Asian population. Therefore, the present study examined the influence of central obesity on circulating levels of adipokines through its interaction with the clustering of cardiometabolic risk factors of MetS including hypergly-cemia, hypertriglyceridemia, dyslipidemia and hypertension in Hong Kong Chinese adults.
   Subjects
   Blood samples from 83 Hong Kong Chinese adults, who were previously screened for MetS according to the guideline of the United States National Cholesterol Education Program Expert Panel Adult Treatment Panel III criteria were selected. Insulin and adipokines, including visfatin, chemerin, plasminogen activator inhibitor-1 (PAI-1), resistin, C-C motif chemokine ligand 2 (CCL-2), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), tumour necrosis factor-alpha (TNF-alpha), leptin and adiponectin were assessed.
   Results
   The interacting effect of central obesity with all of the other four MetS risk factors increased the proinflammatory status of adipokines (TNF-alpha, leptin) and decreased the anti-inflammatory status of adipokine (adiponectin).
   Conclusion
   Our results indicate that the inflammatory status of MetS may be more severe in the presence of central obesity. Adipokines, as biomarkers for pathophysiological changes, may help to improve early patient identification and to predict MetS-associated morbidity and mortality.
C1 [Supriya, Rashmi; Tam, Bjorn T.; Lai, Christopher W.; Cheng, Kenneth K.; Chan, Lawrence W.; Yung, Benjamin Y.] Hong Kong Polytech Univ, Fac Hlth & Social Sci, Dept Hlth Technol & Informat, Kowloon, Hong Kong, Peoples R China.
   [Yu, Angus P.; Sheridan, Sinead; Siu, Parco M.] Univ Hong Kong, Li Ka Shing Fac Med, Sch Publ Hlth, Pokfulam, Hong Kong, Peoples R China.
   [Lee, Paul H.] Hong Kong Polytech Univ, Fac Hlth & Social Sci, Sch Nursing, Kowloon, Hong Kong, Peoples R China.
   [Yau, Sonata Y.] Hong Kong Polytech Univ, Fac Hlth & Social Sci, Dept Rehabil Sci, Kowloon, Hong Kong, Peoples R China.
C3 Hong Kong Polytechnic University; University of Hong Kong; Hong Kong
   Polytechnic University; Hong Kong Polytechnic University
RP Siu, PM (corresponding author), Univ Hong Kong, Li Ka Shing Fac Med, Sch Publ Hlth, Pokfulam, Hong Kong, Peoples R China.
EM pmsiu@hku.hk
RI Lai, Christopher Wai Keung/A-3852-2014; Lee, Paul/F-2549-2010
OI Lai, Christopher Wai Keung/0000-0002-8010-7232; Yau, Sonata Suk
   Yu/0000-0002-7425-6741; Tam, Bjorn T./0000-0001-6740-8674; Supriya,
   Rashmi/0000-0003-2995-1910; Chan, Lawrence/0000-0001-6451-2273; Lee,
   Paul/0000-0002-5729-6450; Yu, Angus, Pak Hung/0000-0002-7684-6198
FU Hong Kong Research Grants Council Hong Kong Ph.D. Fellowship Scheme
   [RTVX PF13-11753]; Hong Kong Polytechnic University Research Fund
   (RTAS); Hong Kong Polytechnic University Research Fund [1-ZE17];
   University of Hong Kong Seed Fund for Basic Research; Hong Kong Research
   Grants Council General Research Fund [PolyU 5632/10M]
FX We declare all the funding or sources of support received during this
   specific study as the following, and all the funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript. This study was supported by the Hong Kong
   Research Grants Council Hong Kong Ph.D. Fellowship Scheme (RTVX
   PF13-11753), the Hong Kong Polytechnic University Research Fund (RTAS
   and 1-ZE17), The University of Hong Kong Seed Fund for Basic Research,
   and the Hong Kong Research Grants Council General Research Fund (PolyU
   5632/10M).
CR Abella V, 2014, J IMMUNOL RES, V2014, DOI 10.1155/2014/343746
   Abu-Farha M, 2014, CARDIOVASC DIABETOL, V13, DOI 10.1186/1475-2840-13-76
   Aekplakorn Wichai, 2004, Journal of the Medical Association of Thailand, V87, P685
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Arner E, 2012, DIABETES, V61, P1986, DOI 10.2337/db11-1508
   Aronson D, 2004, INT J OBESITY, V28, P674, DOI 10.1038/sj.ijo.0802609
   Balistreri CR, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/802078
   Brasier AR, 2002, ARTERIOSCL THROM VAS, V22, P1257, DOI 10.1161/01.ATV.0000021412.56621.A2
   Castrillo A, 2004, ANNU REV CELL DEV BI, V20, P455, DOI 10.1146/annurev.cellbio.20.012103.134432
   Chan JCN, 2009, JAMA-J AM MED ASSOC, V301, P2129, DOI 10.1001/jama.2009.726
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Dahl TB, 2007, CIRCULATION, V115, P972, DOI 10.1161/CIRCULATIONAHA.106.665893
   de Kloet AD, 2010, PHYSIOL BEHAV, V100, P525, DOI 10.1016/j.physbeh.2010.03.018
   Després JP, 2006, EUR HEART J SUPPL, V8, pB4, DOI 10.1093/eurheartj/sul002
   Fontana L, 2007, DIABETES, V56, P1010, DOI 10.2337/db06-1656
   Friedman JM, 1998, NATURE, V395, P763, DOI 10.1038/27376
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gao WG, 2008, INT J OBESITY, V32, P757, DOI 10.1038/sj.ijo.0803797
   Glass CK, 2006, NAT REV IMMUNOL, V6, P44, DOI 10.1038/nri1748
   Goralski KB, 2007, J BIOL CHEM, V282, P28175, DOI 10.1074/jbc.M700793200
   Griffiths PL, 2001, J NUTR, V131, P2692, DOI 10.1093/jn/131.10.2692
   Grundy SM, 2006, J AM COLL CARDIOL, V47, P1093, DOI 10.1016/j.jacc.2005.11.046
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Harkins JM, 2004, J NUTR, V134, P2673, DOI 10.1093/jn/134.10.2673
   HOTAMISLIGIL GS, 1995, J CLIN INVEST, V95, P2409, DOI 10.1172/JCI117936
   Houseknecht KL, 1998, J ANIM SCI, V76, P1405
   Iida KT, 2001, J BIOL CHEM, V276, P32531, DOI 10.1074/jbc.M009894200
   Iwashima Y, 2004, HYPERTENSION, V43, P1318, DOI 10.1161/01.HYP.0000129281.03801.4b
   Jeppesen J, 1997, ARTERIOSCL THROM VAS, V17, P1114, DOI 10.1161/01.ATV.17.6.1114
   Jeppesen J, 2000, HYPERTENSION, V36, P226, DOI 10.1161/01.HYP.36.2.226
   Jernås M, 2006, FASEB J, V20, P1540, DOI 10.1096/fj.05-5678fje
   Jonkers IJ, 2002, AM J MED, V112, P275, DOI 10.1016/S0002-9343(01)01123-8
   Kang YE, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0154003
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kazumi T, 2002, DIABETES CARE, V25, P971, DOI 10.2337/diacare.25.6.971
   Kendal CE, 2007, PLACENTA, V28, P305, DOI 10.1016/j.placenta.2006.03.011
   KOCH AE, 1992, SCIENCE, V258, P1798, DOI 10.1126/science.1281554
   Kroner A, 2014, NEURON, V83, P1098, DOI 10.1016/j.neuron.2014.07.027
   Lafontan M, 2006, CURR OPIN PHARMACOL, V6, P580, DOI 10.1016/j.coph.2006.08.002
   Lee IT, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-43
   LEE IM, 1993, JAMA-J AM MED ASSOC, V270, P2823, DOI 10.1001/jama.270.23.2823
   Lee JM, 2009, J INT MED RES, V37, P1803, DOI 10.1177/147323000903700616
   Lehrke M, 2009, EUR J ENDOCRINOL, V161, P339, DOI 10.1530/EJE-09-0380
   Long YC, 2006, J CLIN INVEST, V116, P1776, DOI 10.1172/JCI29044
   Lumeng CN, 2007, J CLIN INVEST, V117, P175, DOI 10.1172/JCI29881
   Mailiana A, 2010, INDONES BIOMED J, V2, P118, DOI 10.18585/inabj.v2i3.125
   Malik VS, 2013, NAT REV ENDOCRINOL, V9, P13, DOI 10.1038/nrendo.2012.199
   Marsland AL, 2010, METABOLISM, V59, P1801, DOI 10.1016/j.metabol.2010.05.015
   Martins MD, 2012, REV PORT CARDIOL, V31, P711, DOI 10.1016/j.repc.2012.08.002
   Masquio DCL, 2015, BRIT J NUTR, V113, P1920, DOI 10.1017/S0007114515001129
   Mauer J, 2014, NAT IMMUNOL, V15, P423, DOI 10.1038/ni.2865
   McKeown NM, 2004, DIABETES CARE, V27, P538, DOI 10.2337/diacare.27.2.538
   Miyazaki Y, 2003, INT J OBESITY, V27, P88, DOI 10.1038/sj.ijo.0802187
   Moreno LA, 2002, HORM METAB RES, V34, P394, DOI 10.1055/s-2002-33472
   Nascimento H, 2014, PEDIATR RES, V76, P159, DOI 10.1038/pr.2014.73
   Nieto-Vazquez Iria, 2008, Archives of Physiology and Biochemistry, V114, P183, DOI 10.1080/13813450802181047 
   Nishikawa K, 2015, INTERNAL MED, V54, P375, DOI 10.2169/internalmedicine.54.3092
   Olefsky JM, 2010, ANNU REV PHYSIOL, V72, P219, DOI 10.1146/annurev-physiol-021909-135846
   Patel H.J., 2016, LIFE SCI
   Pausova Z, 2000, HYPERTENSION, V36, P14, DOI 10.1161/01.HYP.36.1.14
   Ramachandran A, 2010, J OBES, V2010, DOI 10.1155/2010/868573
   REAVEN GM, 1995, INT J OBESITY, V19, pS2
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Ruderman N, 1998, DIABETES, V47, P699, DOI 10.2337/diabetes.47.5.699
   Sakashita Y, 2015, J DIABETES INVEST, V6, P527, DOI 10.1111/jdi.12327
   Samad F, 1996, J CLIN INVEST, V97, P37, DOI 10.1172/JCI118404
   Sethi JK, 2005, TRENDS MOL MED, V11, P344, DOI 10.1016/j.molmed.2005.06.010
   Sidik Sherina Mohd, 2009, Asia Pac Fam Med, V8, P2, DOI 10.1186/1447-056X-8-2
   Skurk T, 2007, J CLIN ENDOCR METAB, V92, P1023, DOI 10.1210/jc.2006-1055
   Supriya R, 2018, FRONT PHYSIOL, P9, DOI [10.3389fichys.2018.00294/fuIl, DOI 10.3389FICHYS.2018.00294/FUIL]
   Tijerina Amanda J, 2004, Dimens Crit Care Nurs, V23, P237, DOI 10.1097/00003465-200411000-00001
   Titov V N, 2014, Klin Lab Diagn, P27
   Van Guilder GP, 2006, OBESITY, V14, P2127, DOI 10.1038/oby.2006.248
   van Stijn CMW, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0086404
   Weltman A, 2003, METABOLISM, V52, P73, DOI 10.1053/meta.2003.50007
   Wildman RP, 2008, ARCH INTERN MED, V168, P1617, DOI 10.1001/archinte.168.15.1617
   Wittamer V, 2005, J IMMUNOL, V175, P487, DOI 10.4049/jimmunol.175.1.487
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yajnik CS, 2002, J CLIN ENDOCR METAB, V87, P5575, DOI 10.1210/jc.2002-020434
   Yamamoto K, 2005, GUT, V54, P789, DOI 10.1136/gut.2004.046516
   Yoon KH, 2006, LANCET, V368, P1681, DOI 10.1016/S0140-6736(06)69703-1
   Yu AP, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/s13098-015-0108-2
   Yun JE, 2010, METABOLISM, V59, P424, DOI 10.1016/j.metabol.2009.08.012
NR 83
TC 27
Z9 29
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 16
PY 2018
VL 13
IS 8
AR e0201585
DI 10.1371/journal.pone.0201585
PG 20
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GQ6RF
UT WOS:000441850400016
PM 30114249
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Ghosh, S
   Banerjee, KK
   Vaidya, VA
   Kolthur-Seetharam, U
AF Ghosh, S.
   Banerjee, K. K.
   Vaidya, V. A.
   Kolthur-Seetharam, U.
TI Early Stress History Alters Serum Insulin-Like Growth Factor-1 and
   Impairs Muscle Mitochondrial Function in Adult Male Rats
SO JOURNAL OF NEUROENDOCRINOLOGY
LA English
DT Article
DE maternal separation; mitochondria; muscle; IGF-1; metabolism
ID NEONATAL MATERNAL SEPARATION; TYPE-2 DIABETES-MELLITUS; EARLY-LIFE
   STRESS; METABOLIC SYNDROME; IGF-I; TRIGLYCERIDE CLEARANCE; PSYCHOLOGICAL
   STRESS; GENE-EXPRESSION; RISK-FACTOR; DEPRESSION
AB Early-life adversity is associated with an enhanced risk for adult psychopathology. Psychiatric disorders such as depression exhibit comorbidity for metabolic dysfunction, including obesity and diabetes. However, it is poorly understood whether, besides altering anxiety and depression-like behaviour, early stress also evokes dysregulation of metabolic pathways and enhances vulnerability for metabolic disorders. We used the rodent model of the early stress of maternal separation (ES) to examine the effects of early stress on serum metabolites, insulin-like growth factor (IGF)-1 signalling, and muscle mitochondrial content. Adult ES animals exhibited dyslipidaemia, decreased serum IGF1 levels, increased expression of liver IGF binding proteins, and a decline in the expression of specific metabolic genes in the liver and muscle, including Pck1, Lpl, Pdk4 and Hmox1. These changes occurred in the absence of alterations in body weight, food intake, glucose tolerance, insulin tolerance or insulin levels. ES animals also exhibited a decline in markers of muscle mitochondrial content, such as mitochondrial DNA levels and expression of TFAM (transcription factor A, mitochondrial). Furthermore, the expression of several genes involved in mitochondrial function, such as Ppargc1a, Nrf1, Tfam, Cat, Sesn3 and Ucp3, was reduced in skeletal muscle. Adult-onset chronic unpredictable stress resulted in overlapping and distinct consequences from ES, including increased circulating triglyceride levels, and a decline in the expression of specific metabolic genes in the liver and muscle, with no change in the expression of genes involved in muscle mitochondrial function. Taken together, our results indicate that a history of early adversity can evoke persistent changes in circulating IGF-1 and muscle mitochondrial function and content, which could serve to enhance predisposition for metabolic dysfunction in adulthood.
C1 [Ghosh, S.; Banerjee, K. K.; Vaidya, V. A.; Kolthur-Seetharam, U.] Tata Inst Fundamental Res, Dept Biol Sci, Homi Bhabha Rd, Bombay 400005, Maharashtra, India.
C3 Tata Institute of Fundamental Research (TIFR)
RP Kolthur-Seetharam, U (corresponding author), Tata Inst Fundamental Res, Dept Biol Sci, Homi Bhabha Rd, Bombay 400005, Maharashtra, India.
EM ullas@tifr.res.in
OI Ghosh, Shreya/0000-0003-2496-4528
FU TIFR
FX This study was supported by TIFR Intramural Funds to Dr Ullas
   Kolthur-Seetharam and Dr Vidita A. Vaidya.
CR Agudelo LZ, 2014, CELL, V159, P33, DOI 10.1016/j.cell.2014.07.051
   Aschbacher K, 2014, PSYCHONEUROENDOCRINO, V46, P14, DOI 10.1016/j.psyneuen.2014.04.003
   Bale TL, 2010, BIOL PSYCHIAT, V68, P314, DOI 10.1016/j.biopsych.2010.05.028
   Banerjee KK, 2013, MOL CELL BIOL, V33, P252, DOI 10.1128/MCB.00976-12
   Bernardi JR, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0062031
   Boersma GJ, 2014, J NEUROENDOCRINOL, V26, P587, DOI 10.1111/jne.12153
   Brand MD, 2005, CELL METAB, V2, P85, DOI 10.1016/j.cmet.2005.06.002
   Carboni L, 2010, PROG NEURO-PSYCHOPH, V34, P1037, DOI 10.1016/j.pnpbp.2010.05.019
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Cheng ZY, 2009, NAT MED, V15, P1307, DOI 10.1038/nm.2049
   Chuang JC, 2010, BIOL PSYCHIAT, V67, P1075, DOI 10.1016/j.biopsych.2009.12.003
   Cottrell EC, 2008, PHYSIOL BEHAV, V94, P17, DOI 10.1016/j.physbeh.2007.11.017
   de Wit L, 2010, PSYCHIAT RES, V178, P230, DOI 10.1016/j.psychres.2009.04.015
   Depke M, 2008, ENDOCRINOLOGY, V149, P2714, DOI 10.1210/en.2008-0038
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   Duque-Guimaraes DE, 2013, TRENDS ENDOCRIN MET, V24, P525, DOI 10.1016/j.tem.2013.05.006
   Faith MS, 2002, J PSYCHOSOM RES, V53, P935, DOI 10.1016/S0022-3999(02)00308-2
   Fernandez AM, 2012, NAT REV NEUROSCI, V13, P225, DOI 10.1038/nrn3209
   Freimanis Tonny, 2003, Int J Exp Diabesity Res, V4, P21
   Gavrilova O, 2003, J BIOL CHEM, V278, P34268, DOI 10.1074/jbc.M300043200
   Guo SD, 2014, J ENDOCRINOL, V220, pT1, DOI 10.1530/JOE-13-0327
   Heim C, 2001, BIOL PSYCHIAT, V49, P1023, DOI 10.1016/S0006-3223(01)01157-X
   Huot RL, 2001, PSYCHOPHARMACOLOGY, V158, P366, DOI 10.1007/s002130100701
   Karatsoreos IN, 2010, ENDOCRINOLOGY, V151, P2117, DOI 10.1210/en.2009-1436
   Katz LM, 1996, PSYCHONEUROENDOCRINO, V21, P219, DOI 10.1016/0306-4530(95)00043-7
   Kim JJ, 2002, GROWTH HORM IGF RES, V12, P84, DOI 10.1054/ghir.2002.0265
   Knol MJ, 2006, DIABETOLOGIA, V49, P837, DOI 10.1007/s00125-006-0159-x
   Ladd CO, 2004, BIOL PSYCHIAT, V55, P367, DOI 10.1016/j.biopsych.2003.10.007
   Le Roith D, 2001, TRENDS ENDOCRIN MET, V12, P48
   Lee JH, 2012, CELL METAB, V16, P311, DOI 10.1016/j.cmet.2012.08.004
   LeRoith D, 2007, NAT CLIN PRACT ENDOC, V3, P302, DOI 10.1038/ncpendmet0427
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   Nakae J, 2001, ENDOCR REV, V22, P818, DOI 10.1210/edrv.22.6.0452
   Noll JG, 2007, PEDIATRICS, V120, pE61, DOI 10.1542/peds.2006-3058
   Nouwen A, 2010, DIABETOLOGIA, V53, P2480, DOI 10.1007/s00125-010-1874-x
   O'Mahony SM, 2011, PSYCHOPHARMACOLOGY, V214, P71, DOI 10.1007/s00213-010-2010-9
   Paternain L, 2012, DIS MODEL MECH, V5, P691, DOI 10.1242/dmm.009043
   Reagan LP, 2007, CURR OPIN PHARMACOL, V7, P633, DOI 10.1016/j.coph.2007.10.012
   Roden M, 2005, INT J OBESITY, V29, pS111, DOI 10.1038/sj.ijo.0803102
   Saltiel AR, 2001, NATURE, V414, P799, DOI 10.1038/414799a
   Scarpulla RC, 2006, J CELL BIOCHEM, V97, P673, DOI 10.1002/jcb.20743
   Solomon MB, 2011, PHYSIOL BEHAV, V102, P84, DOI 10.1016/j.physbeh.2010.09.024
   Stoney CM, 2002, PSYCHOPHYSIOLOGY, V39, P80, DOI 10.1017/S0048577201020133
   Strüber N, 2014, NEUROSCI BIOBEHAV R, V38, P17, DOI 10.1016/j.neubiorev.2013.10.015
   Su SY, 2014, HYPERTENSION, V64, P201, DOI 10.1161/HYPERTENSIONAHA.113.02755
   Suri D, 2013, BIOL PSYCHIAT, V73, P658, DOI 10.1016/j.biopsych.2012.10.023
   Uchida S, 2010, J NEUROSCI, V30, P15007, DOI 10.1523/JNEUROSCI.1436-10.2010
   Velkoska E, 2011, WORLD J DIABETES, V2, P127, DOI 10.4239/wjd.v2.i8.127
   Xu X, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0075917
NR 49
TC 16
Z9 17
U1 1
U2 13
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0953-8194
EI 1365-2826
J9 J NEUROENDOCRINOL
JI J. Neuroendocrinol.
PD SEP
PY 2016
VL 28
IS 9
DI 10.1111/jne.12397
PG 14
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA EB0WF
UT WOS:000387066500001
PM 27196416
DA 2025-06-11
ER

PT J
AU Pinto, SL
   Juvanhol, LL
   de Oliveira, LL
   Clemente, RC
   Bressan, J
AF Pinto, Sonia Lopes
   Juvanhol, Leidjaira Lopes
   de Oliveira, Leandro Licursi
   Clemente, Rodolfo Castilho
   Bressan, Josefina
TI Changes in oxidative stress markers and cardiometabolic risk factors
   among Roux-en-Y gastric bypass patients after 3-and 12-months
   postsurgery follow-up
SO SURGERY FOR OBESITY AND RELATED DISEASES
LA English
DT Article
DE Oxidative stress; RYGB; Insulin resistance; TyG index; Nitric oxide
ID IDENTIFYING INSULIN-RESISTANCE; METABOLIC SYNDROME; SURROGATE; GLUCOSE;
   TRIGLYCERIDES; SENSITIVITY; CATALASE; INDEXES; OBESITY; ADULTS
AB Background: Evidence shows potential reduction in oxidative stress after Roux-en-Y gastric bypass. However, this outcome can vary, with postsurgery time, type of markers significantly altered, and possible relation with cardiometabolic risk markers, thus indicating the need for more studies.
   Objective: To evaluate changes in oxidative stress and its relation with cardiometabolic risk markers in Roux-en-Y gastric bypass patients after 3 and 12 months postsurgery.
   Setting: Federal University of Vicosa, Brazil.
   Methods: All data were collected before surgery and after 3 and 12 months postsurgery. Biochemical data were collected, and insulin resistance was determined by homeostasis model assessment of insulin resistance, triglyceride/glucose index, and triglycerides/high-density lipoprotein cholesterol. Additionally, catalase, superoxide dismutase, ferric-reducing antioxidant power, nitric oxide, carbonylated protein, and malondialdehyde were analyzed.
   Results: After 3 months postsurgery, excess weight loss was 46%. It increased to 82% after 12 months. We observed a significant reduction in levels of serum insulin, triglycerides, homeostasis model assessment of insulin resistance, triglyceride/glucose index, and triglycerides/high-density lipoprotein cholesterol indices and nitric oxide, throughout the entire study period. Also, reduced levels of total cholesterol, low-density lipoprotein, serum glucose, malondialdehyde, and superoxide dismutase were observed at 3 and 12 months postsurgery compared with baseline. On the other hand, reduction in ferric-reducing antioxidant power occurred only at 3 months postsurgery. We also observed that nitric oxide was positively correlated with triglycerides, percent excess weight loss, total cholesterol/high-density lipoprotein cholesterol, and triglyceride/glucose index.
   Conclusion: Roux-en-Y gastric bypass is able to reduce oxidative stress, insulin resistance, and improve lipid profile after 3 and 12 months postsurgery. Furthermore, changes in oxidative stress and cardiometabolic risk markers are correlated. (C) 2019 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.
C1 [Pinto, Sonia Lopes; Clemente, Rodolfo Castilho] Fed Univ Tocantins, Nutr Course, Quadra 109 North,NS-15 Ave,ALCNO-14,Block Bala 2, BR-77001090 Palmas, Tocantins, Brazil.
   [Pinto, Sonia Lopes; Juvanhol, Leidjaira Lopes; Bressan, Josefina] Univ Fed Vicosa, Dept Nutr & Hlth, Vicosa, MG, Brazil.
   [de Oliveira, Leandro Licursi] Univ Fed Vicosa, Dept Gen Biol, Vicosa, MG, Brazil.
C3 Universidade Federal do Tocantins (UFT); Universidade Federal de Vicosa;
   Universidade Federal de Vicosa
RP Pinto, SL (corresponding author), Fed Univ Tocantins, Nutr Course, Quadra 109 North,NS-15 Ave,ALCNO-14,Block Bala 2, BR-77001090 Palmas, Tocantins, Brazil.
EM sonialopes@uft.edu.br
RI Bressan, Josefina/A-2598-2009; Juvanhol, Leidjaira/AAW-5793-2020;
   Licursi de Oliveira, Leandro/D-3616-2009
OI Licursi de Oliveira, Leandro/0000-0003-4353-7011; Lopes Juvanhol,
   Leidjaira/0000-0001-8012-6006; Bressan, Josefina/0000-0002-4993-9436
FU Coordination for the Improvement of Higher Education Personnel (CAPES)
   [190815/2014]
FX Supported by the Coordination for the Improvement of Higher Education
   Personnel (CAPES, project number 190815/2014).
CR Abbasi F, 2011, METABOLISM, V60, P1673, DOI 10.1016/j.metabol.2011.04.006
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Ben-Noun L, 2003, OBES RES, V11, P226, DOI 10.1038/oby.2003.35
   Benzie IFF, 1996, ANAL BIOCHEM, V239, P70, DOI 10.1006/abio.1996.0292
   Cabrera EJ, 2010, OBES SURG, V20, P42, DOI 10.1007/s11695-009-9988-2
   Callaway CW., 1988, ANTHROPOMETRIC STAND, P39
   Cazzo E, 2014, OBES SURG, V24, P971, DOI 10.1007/s11695-014-1246-6
   da Silva VRG, 2012, EUR J CLIN NUTR, V66, P891, DOI 10.1038/ejcn.2012.17
   Dadalt C, 2013, EUR J GASTROEN HEPAT, V25, P580, DOI 10.1097/MEG.0b013e32835d0ae0
   Dieterich S, 2000, CIRCULATION, V101, P33, DOI 10.1161/01.CIR.101.1.33
   DOUGALL WC, 1991, ENDOCRINOLOGY, V129, P2376, DOI 10.1210/endo-129-5-2376
   Faludi AA, 2017, ARQ BRAS CARDIOL, V109, P1, DOI 10.5935/abc.20170121
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Geloneze B, 2009, ARQ BRAS ENDOCRINOL, V53, P281, DOI 10.1590/S0004-27302009000200020
   Guevara I, 1998, CLIN CHIM ACTA, V274, P177, DOI 10.1016/S0009-8981(98)00060-6
   Hadwan MH, 2016, DATA BRIEF, V6, P194, DOI 10.1016/j.dib.2015.12.012
   Holst JJ, 2018, SURG OBES RELAT DIS, V14, P708, DOI 10.1016/j.soard.2018.03.003
   Jellife D.B., 1966, ASSESSMENT NUTR STAT
   Jentzsch AM, 1996, FREE RADICAL BIO MED, V20, P251, DOI 10.1016/0891-5849(95)02043-8
   Karelis AD, 2007, APPL PHYSIOL NUTR ME, V32, P1089, DOI 10.1139/H07-095
   LEVINE RL, 1990, METHOD ENZYMOL, V186, P464
   Liaskos C, 2018, OBES SURG, V28, P3997, DOI 10.1007/s11695-018-3454-y
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mechanick Jeffrey I, 2008, Endocr Pract, V14 Suppl 1, P1
   Monzo-Beltran L, 2017, REDOX BIOL, V12, P389, DOI 10.1016/j.redox.2017.02.003
   Murri M, 2010, OBES SURG, V20, P363, DOI 10.1007/s11695-009-0021-6
   Salazar Juan, 2018, F1000Res, V7, P44, DOI 10.12688/f1000research.13610.1
   Sansbury BE, 2014, FREE RADICAL BIO MED, V73, P383, DOI 10.1016/j.freeradbiomed.2014.05.016
   Simental-Mendia Luis E., 2008, Metabolic Syndrome and Related Disorders, V6, P299, DOI 10.1089/met.2008.0034
   Skalicky J, 2008, CLIN CHEM LAB MED, V46, P499, DOI 10.1515/CCLM.2008.096
   Tinahones FJ, 2009, OBESITY, V17, P240, DOI 10.1038/oby.2008.536
   Zhao L, 2018, GASTROENTEROL REP, V6, P298, DOI 10.1093/gastro/goy024
NR 32
TC 6
Z9 6
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1550-7289
EI 1878-7533
J9 SURG OBES RELAT DIS
JI Surg. Obes. Relat. Dis.
PD OCT
PY 2019
VL 15
IS 10
BP 1738
EP 1745
DI 10.1016/j.soard.2019.07.014
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA JN4WU
UT WOS:000496900500014
PM 31495634
DA 2025-06-11
ER

PT J
AU Swiatkiewicz, I
   Wozniak, A
   Taub, PR
AF Swiatkiewicz, Iwona
   Wozniak, Alina
   Taub, Pam R.
TI Time-Restricted Eating and Metabolic Syndrome: Current Status and Future
   Perspectives
SO NUTRIENTS
LA English
DT Review
DE time-restricted eating; metabolic syndrome; abdominal obesity;
   hyperglycemia; dyslipidemia; inflammation; oxidative stress;
   cardiometabolic risk; circadian rhythm; eating pattern
ID C-REACTIVE PROTEIN; CARDIOVASCULAR RISK-FACTORS; REDUCED MEAL FREQUENCY;
   CORONARY-HEART-DISEASE; CIRCADIAN-RHYTHMS; ENERGY-EXPENDITURE;
   NORMAL-WEIGHT; FOOD-INTAKE; CARDIOMETABOLIC HEALTH; CALORIC RESTRICTION
AB Metabolic syndrome (MetS) occurs in similar to 30% of adults and is associated with increased risk of cardiovascular disease and diabetes mellitus. MetS reflects the clustering of individual cardiometabolic risk factors including central obesity, elevated fasting plasma glucose, dyslipidemia, and elevated blood pressure. Erratic eating patterns such as eating over a prolonged period per day and irregular meal timing are common in patients with MetS. Misalignment between daily rhythms of food intake and circadian timing system can contribute to circadian rhythm disruption which results in abnormal metabolic regulation and adversely impacts cardiometabolic health. Novel approaches which aim at restoring robust circadian rhythms through modification of timing and duration of daily eating represent a promising strategy for patients with MetS. Restricting eating period during a day (time-restricted eating, TRE) can aid in mitigating circadian disruption and improving cardiometabolic outcomes. Previous pilot TRE study of patients with MetS showed the feasibility of TRE and improvements in body weight and fat, abdominal obesity, atherogenic lipids, and blood pressure, which were observed despite no overt attempt to change diet quantity and quality or physical activity. The present article aims at giving an overview of TRE human studies of individuals with MetS or its components, summarizing current clinical evidence for improving cardiometabolic health through TRE intervention in these populations, and presenting future perspectives for an implementation of TRE to treat and prevent MetS. Previous TRE trials laid the groundwork and indicate a need for further clinical research including large-scale controlled trials to determine TRE efficacy for reducing long-term cardiometabolic risk, providing tools for sustained lifestyle changes and, ultimately, improving overall health in individuals with MetS.
C1 [Swiatkiewicz, Iwona] Nicolaus Copernicus Univ, Coll Med, Dept Cardiol & Internal Med, PL-85094 Bydgoszcz, Poland.
   [Swiatkiewicz, Iwona; Taub, Pam R.] Univ Calif San Diego, Div Cardiovasc Med, La Jolla, CA 92037 USA.
   [Wozniak, Alina] Nicolaus Copernicus Univ, Coll Med, Dept Med Biol & Biochem, PL-85092 Bydgoszcz, Poland.
C3 Nicolaus Copernicus University; University of California System;
   University of California San Diego; Nicolaus Copernicus University
RP Swiatkiewicz, I (corresponding author), Nicolaus Copernicus Univ, Coll Med, Dept Cardiol & Internal Med, PL-85094 Bydgoszcz, Poland.; Swiatkiewicz, I (corresponding author), Univ Calif San Diego, Div Cardiovasc Med, La Jolla, CA 92037 USA.
EM iwona.swiatkiewicz@gmail.com; alina-wozniak@wp.pl; ptaub@health.ucsd.edu
RI Swiatkiewicz, Iwona/H-4279-2014; Wozniak, Alina/H-4699-2014
OI Taub, Pam/0000-0002-0684-0655; Wozniak, Alina/0000-0002-4492-4796
CR Ackermann RT, 2015, AM J PUBLIC HEALTH, V105, P2328, DOI 10.2105/AJPH.2015.302641
   Afshin A, 2017, NEW ENGL J MED, V377, P13, DOI 10.1056/NEJMoa1614362
   Anton SD, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071500
   Antoni R, 2018, J NUTR SCI, V7, DOI 10.1017/jns.2018.13
   Aronson D, 2004, J AM COLL CARDIOL, V44, P2003, DOI 10.1016/j.jacc.2004.08.030
   Aronson D, 2004, INT J OBESITY, V28, P674, DOI 10.1038/sj.ijo.0802609
   Asher G, 2015, CELL, V161, P84, DOI 10.1016/j.cell.2015.03.015
   Bass J, 2012, NATURE, V491, P348, DOI 10.1038/nature11704
   Bays HE, 2013, J CLIN LIPIDOL, V7, P304, DOI 10.1016/j.jacl.2013.04.001
   Beltrán-Sánchez H, 2013, J AM COLL CARDIOL, V62, P697, DOI 10.1016/j.jacc.2013.05.064
   Benjamin EJ, 2019, CIRCULATION, V139, pE56, DOI [10.1161/CIR.0000000000000659, 10.1161/CIR.0000000000000746]
   Cahill LE, 2013, CIRCULATION, V128, P337, DOI 10.1161/CIRCULATIONAHA.113.001474
   Carlson O, 2007, METABOLISM, V56, P1729, DOI 10.1016/j.metabol.2007.07.018
   Cederroth CR, 2019, CELL METAB, V30, P238, DOI 10.1016/j.cmet.2019.06.019
   Chaix A, 2019, ANNU REV NUTR, V39, P291, DOI 10.1146/annurev-nutr-082018-124320
   Chaix A, 2014, CELL METAB, V20, P991, DOI 10.1016/j.cmet.2014.11.001
   Chellappa SL, 2019, TRENDS ENDOCRIN MET, V30, P767, DOI 10.1016/j.tem.2019.07.008
   Chow LS, 2020, OBESITY, V28, P860, DOI [10.1002/oby.22756, 10.1002/oby.22785]
   Chung H, 2016, METABOLISM, V65, P1743, DOI 10.1016/j.metabol.2016.09.006
   Cienfuegos S, 2020, CELL METAB, V32, P366, DOI 10.1016/j.cmet.2020.06.018
   Collet TH, 2016, SLEEP, V39, P1691, DOI 10.5665/sleep.6094
   Dashti HS, 2019, ADV NUTR, V10, P606, DOI 10.1093/advances/nmy131
   de Cabo R, 2019, NEW ENGL J MED, V381, P2541, DOI 10.1056/NEJMra1905136
   Dong TA, 2020, AM J MED, V133, P901, DOI 10.1016/j.amjmed.2020.03.030
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Efeyan A, 2015, NATURE, V517, P302, DOI 10.1038/nature14190
   Ervin R Bethene, 2009, Natl Health Stat Report, P1
   Feinman RD, 2015, NUTRITION, V31, P1, DOI 10.1016/j.nut.2014.06.011
   Gabel K, 2019, APPL PHYSIOL NUTR ME, V44, P903, DOI 10.1139/apnm-2019-0032
   Gabel K, 2019, APPL PHYSIOL NUTR ME, V44, P107, DOI 10.1139/apnm-2018-0389
   Gabel Kelsey, 2018, Nutr Healthy Aging, V4, P345, DOI 10.3233/NHA-170036
   Garaulet M., 2013, International Journal of Obesity, V37, P604, DOI 10.1038/ijo.2012.229
   Garaulet M, 2020, TRENDS ENDOCRIN MET, V31, P192, DOI 10.1016/j.tem.2019.11.011
   Gill S, 2015, CELL METAB, V22, P789, DOI 10.1016/j.cmet.2015.09.005
   Gill S, 2015, SCIENCE, V347, P1265, DOI 10.1126/science.1256682
   Gluszek S, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0235121
   Goris AHC, 2000, AM J CLIN NUTR, V71, P130
   Gupta NJ, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0172852
   Ha K, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102437
   Hall MH, 2008, SLEEP, V31, P635, DOI 10.1093/sleep/31.5.635
   Han TS, 2002, DIABETES CARE, V25, P2016, DOI 10.2337/diacare.25.11.2016
   Hatori M, 2012, CELL METAB, V15, P848, DOI 10.1016/j.cmet.2012.04.019
   Heran BS, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004643.pub3
   Heymsfield SB, 2007, AM J CLIN NUTR, V85, P346, DOI 10.1093/ajcn/85.2.346
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Hutchison AT, 2019, OBESITY, V27, P724, DOI 10.1002/oby.22449
   International Diabetes Federation, CON STAT IDF CONS WO
   Jacobson TA, 2015, J CLIN LIPIDOL, V9, P129, DOI 10.1016/j.jacl.2015.02.003
   Jamshed H, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061234
   Johnston JG, 2016, AM J PHYSIOL-RENAL, V311, pF991, DOI 10.1152/ajprenal.00103.2016
   Kant AK, 2015, J ACAD NUTR DIET, V115, P50, DOI 10.1016/j.jand.2014.06.354
   Katula JA, 2013, AM J PREV MED, V44, pS324, DOI 10.1016/j.amepre.2012.12.015
   Kesztyüs D, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122854
   Kohsaka A, 2007, CELL METAB, V6, P414, DOI 10.1016/j.cmet.2007.09.006
   Kubica A, 2015, PHARMACOLOGY, V95, P50, DOI 10.1159/000371392
   LeCheminant JD, 2013, BRIT J NUTR, V110, P2108, DOI 10.1017/S0007114513001359
   Lopez-Minguez J, 2016, P NUTR SOC, V75, P501, DOI 10.1017/S0029665116000628
   Lowe DA, 2020, JAMA INTERN MED, V180, P1491, DOI 10.1001/jamainternmed.2020.4153
   Malik S, 2005, DIABETES CARE, V28, P690, DOI 10.2337/diacare.28.3.690
   Markwald RR, 2013, P NATL ACAD SCI USA, V110, P5695, DOI 10.1073/pnas.1216951110
   Martens CR, 2020, GEROSCIENCE, V42, P667, DOI 10.1007/s11357-020-00156-6
   Mason IC, 2020, DIABETOLOGIA, V63, P462, DOI 10.1007/s00125-019-05059-6
   Mattis J, 2016, TRENDS ENDOCRIN MET, V27, P192, DOI 10.1016/j.tem.2016.02.003
   Mattson MP, 2014, P NATL ACAD SCI USA, V111, P16647, DOI 10.1073/pnas.1413965111
   Maury E, 2010, CIRC RES, V106, P447, DOI 10.1161/CIRCRESAHA.109.208355
   McAllister MJ, 2020, NUTR RES, V75, P32, DOI 10.1016/j.nutres.2019.12.001
   McHill AW, 2017, OBES REV, V18, P15, DOI 10.1111/obr.12503
   McHill AW, 2014, P NATL ACAD SCI USA, V111, P17302, DOI 10.1073/pnas.1412021111
   Mohebbi I, 2012, INT J OCCUP MED ENV, V25, P383, DOI 10.2478/S13382-012-0051-5
   Moon S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051267
   Moro T, 2016, J TRANSL MED, V14, DOI 10.1186/s12967-016-1044-0
   Mukherji A, 2015, P NATL ACAD SCI USA, V112, pE6691, DOI 10.1073/pnas.1519807112
   Panda S, 2016, SCIENCE, V354, P1008, DOI 10.1126/science.aah4967
   Park HK, 2017, KOREAN J INTERN MED, V32, P239, DOI 10.3904/kjim.2016.229
   Parr EB, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020505
   Pérez-Martínez P, 2017, NUTR REV, V75, P307, DOI 10.1093/nutrit/nux014
   Pot GK, 2016, P NUTR SOC, V75, P475, DOI 10.1017/S0029665116000239
   Puttonen S, 2010, SCAND J WORK ENV HEA, V36, P96, DOI 10.5271/sjweh.2894
   Qian JY, 2019, INT J OBESITY, V43, P1644, DOI 10.1038/s41366-018-0208-9
   Qian JY, 2016, TRENDS ENDOCRIN MET, V27, P282, DOI 10.1016/j.tem.2016.03.005
   Queiroz JD, 2021, CRIT REV FOOD SCI, V61, P2863, DOI 10.1080/10408398.2020.1789550
   Quist JS, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2020-037166
   Rains JL, 2011, FREE RADICAL BIO MED, V50, P567, DOI 10.1016/j.freeradbiomed.2010.12.006
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   Ravussin E, 2019, OBESITY, V27, P1244, DOI 10.1002/oby.22518
   Regmi P, 2020, ISCIENCE, V23, DOI 10.1016/j.isci.2020.101161
   Riou J, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0119161
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Rutter MK, 2004, CIRCULATION, V110, P380, DOI 10.1161/01.CIR.0000136581.59584.0E
   Sattar N, 2003, CIRCULATION, V108, P414, DOI 10.1161/01.CIR.0000080897.52664.94
   Scheer FAJL, 2010, P NATL ACAD SCI USA, V107, P20541, DOI 10.1073/pnas.1006749107
   Scheer FAJL, 2009, P NATL ACAD SCI USA, V106, P4453, DOI 10.1073/pnas.0808180106
   Scuteri A, 2015, EUR J PREV CARDIOL, V22, P486, DOI 10.1177/2047487314525529
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Sperling LS, 2015, J AM COLL CARDIOL, V66, P1050, DOI 10.1016/j.jacc.2015.06.1328
   St-Onge MP, 2017, CIRCULATION, V135, pE96, DOI 10.1161/CIR.0000000000000476
   Stenvers DJ, 2019, NAT REV ENDOCRINOL, V15, P75, DOI 10.1038/s41574-018-0122-1
   Steppan CM, 2001, NATURE, V409, P307, DOI 10.1038/35053000
   Stote KS, 2007, AM J CLIN NUTR, V85, P981, DOI 10.1093/ajcn/85.4.981
   Suliga E, 2018, MED SCI MONITOR, V24, P7633, DOI 10.12659/MSM.907582
   Suliga E, 2017, NUTRIENTS, V9, DOI 10.3390/nu9121366
   Suliga E, 2016, ANN AGR ENV MED, V23, P631, DOI 10.5604/12321966.1226858
   Sulli G, 2018, TRENDS PHARMACOL SCI, V39, P812, DOI 10.1016/j.tips.2018.07.003
   Sutton EF, 2018, CELL METAB, V27, P1212, DOI 10.1016/j.cmet.2018.04.010
   Swiatkiewicz I, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21030807
   Swiatkiewicz I, 2018, KARDIOL POL, V76, P821, DOI 10.5603/KP.a2018.0091
   Sygnowska E, 2012, KARDIOL POL, V70, P718
   Szewczyk-Golec K, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/8494107
   Szewczyk-Golec K, 2015, J PINEAL RES, V59, P277, DOI 10.1111/jpi.12257
   Tinsley GM, 2019, AGING-US, V11, P8741, DOI 10.18632/aging.102384
   Tinsley GM, 2019, AM J CLIN NUTR, V110, P628, DOI 10.1093/ajcn/nqz126
   Tinsley GM, 2017, EUR J SPORT SCI, V17, P200, DOI 10.1080/17461391.2016.1223173
   Vera B, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-017-18268-z
   Vollmers C, 2009, P NATL ACAD SCI USA, V106, P21453, DOI 10.1073/pnas.0909591106
   Wilkinson MJ, 2020, CELL METAB, V31, P92, DOI 10.1016/j.cmet.2019.11.004
   Xie YL, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00682
   Zarrinpar A, 2016, TRENDS ENDOCRIN MET, V27, P69, DOI 10.1016/j.tem.2015.11.007
   Zarrinpar A, 2014, CELL METAB, V20, P1006, DOI 10.1016/j.cmet.2014.11.008
   Zaulkffali AS, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102525
   Zeb F, 2020, BRIT J NUTR, V123, P1216, DOI 10.1017/S0007114519003428
   Zomer E, 2016, OBES REV, V17, P1001, DOI 10.1111/obr.12433
NR 121
TC 71
Z9 76
U1 0
U2 35
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2021
VL 13
IS 1
AR 221
DI 10.3390/nu13010221
PG 24
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA PW4IK
UT WOS:000610634600001
PM 33466692
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jones, KT
   Shelton, RC
   Wan, J
   Li, L
AF Jones, Kristian T.
   Shelton, Richard C.
   Wan, Jun
   Li, Li
TI Impact of acute psychological stress on cardiovascular risk factors in
   face of insulin resistance
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Article
DE Acute psychological stress; cardiovascular disease; risk factors;
   insulin resistance; cortisol; cytokines
ID METABOLIC SYNDROME; SENSITIVITY; RESPONSES; OBESITY; ATHEROSCLEROSIS;
   NEUROENDOCRINE; POLYMORPHISM; EXERCISE; DISEASE; ANGER
AB Individuals with insulin resistance (IR) are at greater risk for cardiovascular disease (CVD). Psychological stress may contribute to develop CVD in IR, although mechanisms are poorly understood. Our aim was to test the hypothesis that individuals with IR have enhanced emotional and physiological responses to acute psychological stress, leading to increased CVD risk. Sixty participants were enrolled into the study, and classified into IR group (n = 31) and insulin sensitive group (n = 29) according to the Quantitative insulin sensitivity check index, which was calculated based on an oral glucose tolerance test. The Trier social stress test, a standardized experimental stress paradigm, was performed on each participant, and emotional and physiological responses were examined. Blood was collected from each subject for insulin, cytokines, and cortisol measurements. Compared with the insulin-sensitive group, individuals with IR had significantly lower ratings of energy and calm, but higher fatigue levels in response to acute stressors. Individuals with IR also showed blunted heart rate reactivity following stress. In addition, the IR status was worsened by acute psychological stress as demonstrated by further increased insulin secretion. Furthermore, individuals with IR showed significantly increased levels of leptin and interleukin-6, but decreased levels of adiponectin, at baseline, stress test, and post-stress period. Our findings in individuals with IR under acute stress would allow a better understanding of the risks for developing CVD and to tailor the interventions for better outcomes.
C1 [Jones, Kristian T.] Meharry Med Coll, Nashville, TN 37208 USA.
   [Shelton, Richard C.; Li, Li] Univ Alabama Birmingham, Dept Psychiat & Behav Neurobiol, 1720 Univ Blvd, Birmingham, AL 35294 USA.
   [Wan, Jun] Wuhan Univ, Dept Cardiol, Renmin Hosp, Wuhan 430072, Peoples R China.
C3 Meharry Medical College; University of Alabama System; University of
   Alabama Birmingham; Wuhan University
RP Li, L (corresponding author), Univ Alabama Birmingham, Dept Psychiat & Behav Neurobiol, 1720 Univ Blvd, Birmingham, AL 35294 USA.
EM lili978@uab.edu
RI Li, Li/M-3237-2016; Shelton, Richard/AAC-4137-2022
FU Brain and Behavior Research Foundation [21623]; National Institute of
   Diabetes And Digestive And Kidney Diseases [P30DK056336, P30DK079626];
   University of Alabama at Birmingham
FX This work was supported by a Young Investigator Award from the Brain and
   Behavior Research Foundation [21623] to L. L. and Awards [P30DK056336,
   P30DK079626], from the National Institute of Diabetes And Digestive And
   Kidney Diseases to Nutrition Obesity Research Center and Diabetes
   Research Center, respectively, at the University of Alabama at
   Birmingham.
CR Ascaso JF, 2003, DIABETES CARE, V26, P3320, DOI 10.2337/diacare.26.12.3320
   Balsan GA, 2015, REV ASSOC MED BRAS, V61, P72, DOI 10.1590/1806-9282.61.01.072
   Birkett MA, 2011, JOVE-J VIS EXP, DOI 10.3791/3238
   Black PH, 2006, MED HYPOTHESES, V67, P879, DOI 10.1016/j.mehy.2006.04.008
   Black PH, 2002, BRAIN BEHAV IMMUN, V16, P622, DOI 10.1016/S0889-1591(02)00021-1
   Blumenthal JA, 2005, JAMA-J AM MED ASSOC, V293, P1626, DOI 10.1001/jama.293.13.1626
   Brotman DJ, 2007, LANCET, V370, P1089, DOI 10.1016/S0140-6736(07)61305-1
   Brunner EJ, 2005, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002128.pub2
   Desouza C, 2001, Curr Diab Rep, V1, P140, DOI 10.1007/s11892-001-0026-6
   Dimsdale JE, 2008, J AM COLL CARDIOL, V51, P1237, DOI 10.1016/j.jacc.2007.12.024
   Fernández-Real JM, 1999, DIABETOLOGIA, V42, P1367, DOI 10.1007/s001250051451
   Fernández-Real JM, 2000, DIABETES CARE, V23, P831, DOI 10.2337/diacare.23.6.831
   Fernández-Real JM, 2000, DIABETES, V49, P517, DOI 10.2337/diabetes.49.3.517
   Fernández-Real JM, 1999, DIABETES CARE, V22, P868, DOI 10.2337/diacare.22.5.868
   FREDRIKSON M, 1992, BIOL PSYCHOL, V34, P45, DOI 10.1016/0301-0511(92)90023-N
   Gerra G, 2001, PSYCHONEUROENDOCRINO, V26, P91, DOI 10.1016/S0306-4530(00)00046-9
   Hamer M, 2008, J AM COLL CARDIOL, V52, P2156, DOI 10.1016/j.jacc.2008.08.057
   Hamer M, 2006, SPORTS MED, V36, P829, DOI 10.2165/00007256-200636100-00002
   Hrebícek J, 2002, J CLIN ENDOCR METAB, V87, P144, DOI 10.1210/jc.87.1.144
   Ingram KH, 2012, J CLIN ENDOCR METAB, V97, pE1182, DOI 10.1210/jc.2011-2963
   Kendall DM, 2002, AM J MANAG CARE, V8, pS635
   Kirschbaum C, 1999, J CLIN ENDOCR METAB, V84, P4292, DOI 10.1210/jc.84.11.4292
   KIRSCHBAUM C, 1993, NEUROPSYCHOBIOLOGY, V28, P76, DOI 10.1159/000119004
   Lampert R, 2002, CIRCULATION, V106, P1800, DOI 10.1161/01.CIR.0000031733.51374.C1
   Matsuda M, 1999, DIABETES CARE, V22, P1462, DOI 10.2337/diacare.22.9.1462
   Mittleman MA, 1997, ARCH INTERN MED, V157, P769, DOI 10.1001/archinte.157.7.769
   Muniyappa R, 2008, AM J PHYSIOL-ENDOC M, V294, pE15, DOI 10.1152/ajpendo.00645.2007
   Pruessner JC, 2003, PSYCHONEUROENDOCRINO, V28, P916, DOI 10.1016/S0306-4530(02)00108-7
   Räikkönen K, 2004, PSYCHOSOM MED, V66, P903, DOI 10.1097/01.psy.0000143638.31297.11
   Reaven Gerald, 2003, J Clin Hypertens (Greenwich), V5, P269, DOI 10.1111/j.1524-6175.2003.01764.x
   ROSENBAUM S, 1985, ANN HUM BIOL, V12, P115, DOI 10.1080/03014468500007621
   Sheehan DV, 1998, J CLIN PSYCHIAT, V59, P22, DOI 10.4088/JCP.09m05305whi
   Smitka Kvido, 2015, Prague Med Rep, V116, P87, DOI 10.14712/23362936.2015.49
   Strike PC, 2005, PSYCHOSOM MED, V67, P179, DOI 10.1097/01.psy.0000155663.93160.d2
   Tsuji H, 1996, CIRCULATION, V94, P2850, DOI 10.1161/01.CIR.94.11.2850
   Walton Kenneth G, 2004, Cardiol Rev, V12, P262, DOI 10.1097/01.crd.0000113021.96119.78
   Weyer C, 1999, J CLIN INVEST, V104, P787, DOI 10.1172/JCI7231
   Weyer C, 1999, DIABETES, V48, P2197, DOI 10.2337/diabetes.48.11.2197
   Wittstein IS, 2005, NEW ENGL J MED, V352, P539, DOI 10.1056/NEJMoa043046
NR 39
TC 9
Z9 13
U1 0
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1025-3890
EI 1607-8888
J9 STRESS
JI Stress
PY 2016
VL 19
IS 6
BP 585
EP 592
DI 10.1080/10253890.2016.1231804
PG 8
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA EJ4RW
UT WOS:000393205500005
PM 27588343
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Williams, KL
   Ruekert, L
   Lum, C
AF Williams, Kristal L.
   Ruekert, Laura
   Lum, Cheen
TI Treatment of bipolar disorder: A focus on medication therapy for mania
SO FORMULARY
LA English
DT Article
ID LONG-TERM TREATMENT; I DISORDER; DOUBLE-BLIND; MAINTENANCE TREATMENT;
   ARIPIPRAZOLE MONOTHERAPY; OPEN-LABEL; ADD-ON; LITHIUM; OLANZAPINE; TRIAL
AB Bipolar disorder (BPD) is a recurrent psychiatric disorder characterized by episodes of mania and hypomania, depression, or mixed episodes. Individuals with BPD often experience anxiety and decreased cognitive performance and productivity. BPD has emerged as a major health concern, with lifelong social and occupational impairment and poor prognosis secondary to its substantially elevated morbidity and mortality rates, which are largely due to associated cardiovascular disease, metabolic syndrome, substance abuse or misuse, and potential for physical self-harm. The lifetime prevalence of bipolar spectrum disorders is approximately 3% to 7% of the population. Given the disease complexity, individuals with BPD often require lifelong pharmacological therapy to achieve desired treatment outcomes. In recent years there has been an explosion of new investigations into the pathophysiology of BPD and its medication therapies. This article will review current, emerging, and controversial therapies for the treatment of BPD, specifically the mania aspect. (Formulary. 2011;46:82-97.)
C1 [Williams, Kristal L.; Ruekert, Laura] Butler Univ, Coll Pharm & Hlth Sci, Indianapolis, IN 46208 USA.
   [Williams, Kristal L.] Indiana Univ Hlth, Indianapolis, IN USA.
   [Ruekert, Laura; Lum, Cheen] Community Hosp N, Indianapolis, IN USA.
C3 Butler University; Indiana University Health; IU Health University
   Hospital
RP Williams, KL (corresponding author), Butler Univ, Coll Pharm & Hlth Sci, Indianapolis, IN 46208 USA.
RI Williams, Kenneth/O-5181-2014; Ruekert, Laura/T-2126-2019
CR Amann B, 2011, J PSYCHOPHARMACOL, V25, P1289, DOI 10.1177/0269881110376695
   Amrollahi Z, 2011, J AFFECT DISORDERS, V129, P327, DOI 10.1016/j.jad.2010.08.015
   [Anonymous], 2010, VA/DoD Clinical Practice Guideline for Opioid Therapy for Chronic Pain Version 3.0
   [Anonymous], BIPOLAR DISORDER PHA
   [Anonymous], BIPOLAR DISORDER EPI
   [Anonymous], ANTIPSYCHOTIC MEDICA
   Benedetti A, 2004, J AFFECT DISORDERS, V79, P273, DOI 10.1016/S0165-0327(02)00407-X
   Berghöfer A, 2008, J CLIN PSYCHIAT, V69, P1860, DOI 10.4088/JCP.v69n1203
   Berwaerts J, 2012, J AFFECT DISORDERS, V136, pE51, DOI 10.1016/j.jad.2010.06.030
   Bowden C, 2008, INT CLIN PSYCHOPHARM, V23, P254, DOI 10.1097/YIC.0b013e3282fd827c
   Bowden CL, 2010, INT CLIN PSYCHOPHARM, V25, P60, DOI 10.1097/YIC.0b013e328333ac1b
   Bowden CL, 2010, J CLIN PSYCHIAT, V71, P130, DOI 10.4088/JCP.09m05482yel
   Bowden CL, 2003, ARCH GEN PSYCHIAT, V60, P392, DOI 10.1001/archpsyc.60.4.392
   Campos RN, 2010, TRIALS, V11, DOI 10.1186/1745-6215-11-72
   Carta Mauro Giovanni, 2006, Clin Pract Epidemiol Ment Health, V2, P2, DOI 10.1186/1745-0179-2-2
   Ceron-Litvoc D, 2009, HUM PSYCHOPHARM CLIN, V24, P19, DOI 10.1002/hup.990
   Cipriani A, 2010, J PSYCHOPHARMACOL, V24, P1729, DOI 10.1177/0269881109106900
   Geddes JR, 2010, LANCET, V375, P385, DOI 10.1016/S0140-6736(09)61828-6
   Green AI, 2000, AM J PSYCHIAT, V157, P982, DOI 10.1176/appi.ajp.157.6.982
   Hirschfeld R.M.A., 2005, Guideline watch: Practice guideline for the treatment of patients with bipolar disorder, V2nd, DOI DOI 10.1176/FOC.5.1.34
   Hirschfeld RMA, 2004, INT J NEUROPSYCHOPH, V7, P507, DOI 10.1017/S1461145704004651
   Jamison KayRedfield., 2007, Manic-Depressive Illness: Bipolar Disorders and Recurrent Depression, V2nd
   Kane JM, 2002, AM J PSYCHIAT, V159, P1, DOI 10.1176/appi.ajp.159.1.1
   Keck PE, 2009, J AFFECT DISORDERS, V112, P36, DOI 10.1016/j.jad.2008.05.014
   Keck PE, 2007, J CLIN PSYCHIAT, V68, P1480, DOI 10.4088/JCP.v68n1003
   Ketter TA, 2006, J CLIN PSYCHIAT, V67, P95, DOI 10.4088/JCP.v67n0113
   Licht RW, 2010, BIPOLAR DISORD, V12, P483, DOI 10.1111/j.1399-5618.2010.00836.x
   Macfadden W, 2009, BIPOLAR DISORD, V11, P827, DOI 10.1111/j.1399-5618.2009.00761.x
   Maina G, 2007, J AFFECT DISORDERS, V99, P247, DOI 10.1016/j.jad.2006.09.007
   Malhi GS, 2009, DRUGS, V69, P2063, DOI 10.2165/11318850-000000000-00000
   McIntyre RS, 2010, J AFFECT DISORDERS, V126, P358, DOI 10.1016/j.jad.2010.04.005
   McIntyre RS, 2010, J AFFECT DISORDERS, V122, P27, DOI 10.1016/j.jad.2009.12.028
   McIntyre RS, 2010, CLIN THER, V32, pS32, DOI 10.1016/j.clinthera.2010.01.022
   McIntyre RS, 2009, BIPOLAR DISORD, V11, P815, DOI 10.1111/j.1399-5618.2009.00749.x
   McIntyre RS, 2009, BIPOLAR DISORD, V11, P673, DOI 10.1111/j.1399-5618.2009.00748.x
   Narasimhan Meera, 2007, Neuropsychiatr Dis Treat, V3, P579
   Oluboka OJ, 2002, BIPOLAR DISORD, V4, P341, DOI 10.1034/j.1399-5618.2002.01224.x
   Quiroz JA, 2010, BIOL PSYCHIAT, V68, P156, DOI 10.1016/j.biopsych.2010.01.015
   Shafti SS, 2010, J AFFECT DISORDERS, V122, P273, DOI 10.1016/j.jad.2009.08.013
   Suppes T, 2005, J CLIN PSYCHIAT, V66, P870, DOI 10.4088/JCP.v66n0710
   Suppes T, 2007, AUST NZ J PSYCHIAT, V41, P397, DOI 10.1080/00048670701261186
   Suppes T, 2009, AM J PSYCHIAT, V166, P476, DOI 10.1176/appi.ajp.2008.08020189
   Thomas Pierre, 2008, Neuropsychiatr Dis Treat, V4, P675
   Tohen M, 2005, AM J PSYCHIAT, V162, P1281, DOI 10.1176/appi.ajp.162.7.1281
   Tohen M, 2008, BRIT J PSYCHIAT, V192, P135, DOI 10.1192/bjp.bp.107.041301
   Vieta E, 2010, J PSYCHOPHARMACOL, V24, P547, DOI 10.1177/0269881108099418
   Vieta E, 2008, WORLD J BIOL PSYCHIA, V9, P219, DOI 10.1080/15622970701530917
   Vieta E, 2008, J AFFECT DISORDERS, V109, P251, DOI 10.1016/j.jad.2008.06.001
   Vieta E, 2010, BIPOLAR DISORD, V12, P230, DOI 10.1111/j.1399-5618.2010.00815.x
   Vieta E, 2008, INT J NEUROPSYCHOPH, V11, P445, DOI 10.1017/S1461145708008596
   Yatham LN, 2009, BIPOLAR DISORD, V11, P225, DOI 10.1111/j.1399-5618.2009.00672.x
   Yildiz A, 2008, ARCH GEN PSYCHIAT, V65, P255, DOI 10.1001/archgenpsychiatry.2007.43
NR 52
TC 0
Z9 0
U1 0
U2 7
PU ADVANSTAR COMMUNICATIONS INC
PI DULUTH
PA 131 W 1ST STREET, DULUTH, MN 55802 USA
SN 1082-801X
EI 1938-1166
J9 FORMULARY
JI Formulary
PD MAR
PY 2011
VL 46
IS 3
BP 82
EP +
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 741AT
UT WOS:000288836200002
DA 2025-06-11
ER

PT J
AU Simáo, ANC
   Lozovoy, MAB
   Dichi, I
AF Colado Simao, Andrea Name
   Batisti Lozovoy, Marcell Alysson
   Dichi, Isaias
TI The uric acid metabolism pathway as a therapeutic target in
   hyperuricemia related to metabolic syndrome
SO EXPERT OPINION ON THERAPEUTIC TARGETS
LA English
DT Review
DE inflammation; insulin resistance; metabolic syndrome; oxidative stress;
   uric acid
ID IMPROVES ENDOTHELIAL FUNCTION; INSULIN-RESISTANCE SYNDROME; SHORT-TERM
   TREATMENT; C-REACTIVE PROTEIN; RISK-FACTOR; CARDIOVASCULAR RISK;
   BLOOD-PRESSURE; PLASMA-CONCENTRATIONS; ANTIOXIDANT CAPACITY; OXIDATIVE
   STRESS
AB Introduction: Uric acid (UA) increase is considered an important risk factor for the development of cardiovascular disease (CVD) favoring oxidative stress and endothelial dysfunction and is also involved in metabolic syndrome (MS) pathophysiology.
   Areas covered: Insulin has a physiological action on renal tubules, causing a reduction in UA clearance, what could explain the hyperuricemia found in MS. On the other hand, it was also hypothesized a causal role of UA in fructose-induced MS. Moreover, it has been suggested that higher UA levels predict the development of MS. MS subjects present a redox imbalance and UA participates in this process. UA can contribute to oxidative stress present in MS; however, it has also an important role in the antioxidant defense system. Although UA may have a protective effect due to its antioxidant properties, it is clear that the dominant effect of UA in MS is deleterious. All-cause mortality and CVD have been shown to be increased with higher UA levels.
   Expert opinion: It is extremely important to prescribe drugs which concomitantly decrease hyperuricemia and improve co-morbidities associated with hyperuricemia. Long-term studies to verify the consequences of decreasing UA concentration below current recommendations in asymptomatic patients are needed.
C1 [Dichi, Isaias] Univ Londrina, Dept Internal Med, BR-86038440 Londrina, Parana, Brazil.
   [Colado Simao, Andrea Name] Univ Londrina, Dept Pathol Clin Anal & Toxicol, BR-86038440 Londrina, Parana, Brazil.
   [Batisti Lozovoy, Marcell Alysson] Univ N Parana UNOPAR, Dept Clin Anal, BR-86041120 Londrina, Parana, Brazil.
C3 University Norte Parana
RP Dichi, I (corresponding author), Univ Londrina, Dept Internal Med, Rua Robert Koch 60 Bairro Cervejaria, BR-86038440 Londrina, Parana, Brazil.
EM dichi@sercomtel.com.br
RI Lozovoy, Marcell/AAM-4897-2021; Simão, Andrea/AAM-4892-2021
CR Alderman M, 2004, CURR MED RES OPIN, V20, P369, DOI 10.1185/030079904125002982
   Alper AB, 2005, HYPERTENSION, V45, P34, DOI 10.1161/01.HYP.0000150783.79172.bb
   AMES BN, 1981, P NATL ACAD SCI-BIOL, V78, P6858, DOI 10.1073/pnas.78.11.6858
   Asl SZ, 2008, CLIN BIOCHEM, V41, P1342, DOI 10.1016/j.clinbiochem.2008.08.076
   Augusto O, 2002, FREE RADICAL BIO MED, V32, P841, DOI 10.1016/S0891-5849(02)00786-4
   Baldwin W, 2011, DIABETES, V60, P1258, DOI 10.2337/db10-0916
   Barskova VG, 2005, TERAPEVT ARKH, V77, P44
   Bedir A, 2003, JPN HEART J, V44, P527, DOI 10.1536/jhj.44.527
   CANNON PJ, 1966, NEW ENGL J MED, V275, P457, DOI 10.1056/NEJM196609012750902
   Caspi D, 2000, ARTHRITIS RHEUM
   CECCHINI R, 1990, FREE RADICAL RES COM, V10, P245, DOI 10.3109/10715769009149893
   Choi HK, 2005, ANN INTERN MED, V143, P499, DOI 10.7326/0003-4819-143-7-200510040-00009
   Choi HK, 2007, AM J MED, V120, P442, DOI 10.1016/j.amjmed.2006.06.040
   Choi JWJ, 2008, ARTHRIT RHEUM-ARTHR, V59, P109, DOI 10.1002/art.23245
   Clausen JO, 1998, EUR J ENDOCRINOL, V138, P63, DOI 10.1530/eje.0.1380063
   Simao ANC, 2008, NUTRITION, V24, P675, DOI 10.1016/j.nut.2008.03.021
   Cook S, 2003, SWISS MED WKLY, V133, P360
   Emmerson B, 1998, ANN RHEUM DIS, V57, P509, DOI 10.1136/ard.57.9.509
   FACCHINI F, 1991, JAMA-J AM MED ASSOC, V266, P3008, DOI 10.1001/jama.266.21.3008
   Fam AG, 2002, J RHEUMATOL, V29, P1350
   Fang J, 2000, JAMA-J AM MED ASSOC, V283, P2404, DOI 10.1001/jama.283.18.2404
   Feig DI, 2008, NEW ENGL J MED, V359, P1811, DOI 10.1056/NEJMra0800885
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Filippatos TD, 2005, CURR MED RES OPIN, V21, P457, DOI 10.1185/030079905X38132
   Förstermann U, 2006, BIOL CHEM, V387, P1521, DOI 10.1515/BC.2006.190
   Ford ES, 2007, CIRCULATION, V115, P2526, DOI 10.1161/CIRCULATIONAHA.106.657627
   FOX IH, 1981, METABOLISM, V30, P616, DOI 10.1016/0026-0495(81)90142-6
   Fruehwald-Schultes B, 2002, METABOLISM, V51, P531, DOI 10.1053/meta.2002.31332
   Gagliardi ACM, 2009, ATHEROSCLEROSIS, V202, P11, DOI 10.1016/j.atherosclerosis.2008.05.022
   George J, 2006, CIRCULATION, V114, P2508, DOI 10.1161/CIRCULATIONAHA.106.651117
   George Jacob, 2009, Ther Clin Risk Manag, V5, P799
   George J, 2009, VASC HEALTH RISK MAN, V5, P265, DOI 10.2147/VHRM.S4265
   Gercsh C, 2008, NUCLEOS NUCLEOT, V27, P967
   Haffner SM, 2003, AM J CARDIOL, V92, p18J, DOI 10.1016/S0002-9149(03)00612-X
   Halliwell B, 1999, ANTIOXIDANT PROTECTI, p[19, 197]
   Hayden Melvin R, 2004, Nutr Metab (Lond), V1, P10, DOI 10.1186/1743-7075-1-10
   Heinig M, 2006, CLEV CLIN J MED, V73, P1059, DOI 10.3949/ccjm.73.12.1059
   Ho WJ, 2010, RHEUMATOLOGY, V49, P1929, DOI 10.1093/rheumatology/keq184
   Hotta K, 2001, DIABETES, V50, P1126, DOI 10.2337/diabetes.50.5.1126
   Hotta K, 2000, ARTERIOSCL THROM VAS, V20, P1595, DOI 10.1161/01.ATV.20.6.1595
   Hovind P, 2009, DIABETES, V58, P1668, DOI 10.2337/db09-0014
   Imaram W, 2010, FREE RADICAL BIO MED, V49, P275, DOI 10.1016/j.freeradbiomed.2010.04.010
   Iwashima Y, 2004, HYPERTENSION, V43, P1318, DOI 10.1161/01.HYP.0000129281.03801.4b
   Johnson RJ, 2005, HYPERTENSION, V45, P18, DOI 10.1161/01.HYP.0000150785.39055.e8
   Johnson RJ, 2005, AM J HYPERTENS, V18, P431, DOI 10.1016/j.amjhyper.2004.08.035
   Johnson RJ, 2002, NEW ENGL J MED, V346, P913, DOI 10.1056/NEJMra011078
   Kanellis J, 2005, SEMIN NEPHROL, V25, P39, DOI 10.1016/j.semnephrol.2004.09.007
   Kern PA, 2001, AM J PHYSIOL-ENDOC M, V280, pE745
   Khosla UM, 2005, KIDNEY INT, V67, P1739, DOI 10.1111/j.1523-1755.2005.00273.x
   Kiortsis DN, 2005, DIABETES METAB, V31, P15, DOI 10.1016/S1262-3636(07)70161-1
   Koprowski H, 2001, ANN NEUROL, V49, P139, DOI 10.1002/1531-8249(200101)49:1<139::AID-ANA28>3.0.CO;2-A
   Kuzkaya N, 2005, BIOCHEM PHARMACOL, V70, P343, DOI 10.1016/j.bcp.2005.05.009
   Kylin E., 1923, Zentralblatt fur innere Medizin, V44, P105
   Liamis G, 1999, AM J KIDNEY DIS, V34, P594, DOI 10.1016/S0272-6386(99)70093-4
   Lin JD, 2007, METABOLISM, V56, P751, DOI 10.1016/j.metabol.2007.01.006
   Lin KC, 2004, J RHEUMATOL, V31, P1152
   Lin Shi-Dou, 2006, J Chin Med Assoc, V69, P512
   Louthrenoo W, 2002, JCR-J CLIN RHEUMATOL, V8, P299, DOI 10.1097/00124743-200212000-00003
   Maeda N, 2001, DIABETES, V50, P2094, DOI 10.2337/diabetes.50.9.2094
   Maxwell SRJ, 1997, EUR J CLIN INVEST, V27, P484, DOI 10.1046/j.1365-2362.1997.1390687.x
   Mazzali M, 2001, HYPERTENSION, V38, P1101, DOI 10.1161/hy1101.092839
   Mene P, 2008, J HYPERTENS, V26, P2085, DOI 10.1097/HJH.0b013e32830e4945
   Mercuro G, 2004, AM J CARDIOL, V94, P932, DOI 10.1016/j.amjcard.2004.06.032
   Milionis HJ, 2004, AM HEART J, V148, P635, DOI 10.1016/j.ahj.2004.04.005
   Molnár D, 2004, INT J OBESITY, V28, P1197, DOI 10.1038/sj.ijo.0802719
   Muscelli E, 1996, AM J HYPERTENS, V9, P746, DOI 10.1016/0895-7061(96)00098-2
   Nakagawa T, 2006, AM J PHYSIOL-RENAL, V290, pF625, DOI 10.1152/ajprenal.00140.2005
   Nieto FJ, 2000, ATHEROSCLEROSIS, V148, P131, DOI 10.1016/S0021-9150(99)00214-2
   Niskanen LK, 2004, ARCH INTERN MED, V164, P1546, DOI 10.1001/archinte.164.14.1546
   Onat A, 2006, AM J HYPERTENS, V19, P1055, DOI 10.1016/j.amjhyper.2006.02.014
   Ouchi N, 2000, CIRCULATION, V102, P1296, DOI 10.1161/01.CIR.102.11.1296
   Ouchi N, 1999, CIRCULATION, V100, P2473, DOI 10.1161/01.CIR.100.25.2473
   Patel DA, 2006, METABOLISM, V55, P1551, DOI 10.1016/j.metabol.2006.06.028
   Rathmann W, 1998, ANN EPIDEMIOL, V8, P250, DOI 10.1016/S1047-2797(97)00204-4
   Sánchez-Lozada LG, 2008, AM J PHYSIOL-RENAL, V294, pF710, DOI 10.1152/ajprenal.00454.2007
   Sánchez-Lozada LG, 2006, CURR OPIN NEPHROL HY, V15, P30, DOI 10.1097/01.mnh.0000199010.33929.7f
   Santaniemi M, 2006, EUR J ENDOCRINOL, V155, P745, DOI 10.1530/eje.1.02287
   Santos AC, 2005, INT J OBESITY, V29, P1452, DOI 10.1038/sj.ijo.0803035
   Sautin YY, 2008, NUCLEOS NUCLEOT NUCL, V27, P608, DOI 10.1080/15257770802138558
   Sautin YY, 2007, AM J PHYSIOL-CELL PH, V293, pC584, DOI 10.1152/ajpcell.00600.2006
   Savage PJ, 1998, ARCH INTERN MED, V158, P741, DOI 10.1001/archinte.158.7.741
   Sekine T, 2006, AM J PHYSIOL-RENAL, V290, pF251, DOI 10.1152/ajprenal.00439.2004
   Sennesael JJ, 1996, AM J KIDNEY DIS, V27, P701, DOI 10.1016/S0272-6386(96)90106-7
   Simao ANC, 2012, J NUTR METAB IN PRES, V2012
   Sui XM, 2008, METABOLISM, V57, P845, DOI 10.1016/j.metabol.2008.01.030
   Sundström J, 2005, HYPERTENSION, V45, P28, DOI 10.1161/01.HYP.0000150784.92944.9a
   Szabo C, 2007, NAT REV DRUG DISCOV, V6, P662, DOI 10.1038/nrd2222
   Tamakoshi K, 2003, INT J OBESITY, V27, P443, DOI 10.1038/sj.ijo.0802260
   Tetradze L., 2007, Georgian Medical News, V151, P44
   Tinahones JF, 1997, J CLIN ENDOCR METAB, V82, P1188, DOI 10.1210/jc.82.4.1188
   Tomita M, 2000, J Epidemiol, V10, P403
   Trayhurn P, 2004, BRIT J NUTR, V92, P347, DOI 10.1079/BJN20041213
   Tsouli SG, 2006, J CARDIOVASC PHARM T, V11, P1, DOI 10.1177/107424840601100101
   Tsouli SG, 2006, METABOLISM, V55, P1293, DOI 10.1016/j.metabol.2006.05.013
   VUORINENMARKKOLA H, 1994, J CLIN ENDOCR METAB, V78, P25, DOI 10.1210/jc.78.1.25
   Waring WS, 2000, QJM-INT J MED, V93, P707, DOI 10.1093/qjmed/93.11.707
   Williams IL, 2002, INT J OBESITY, V26, P754, DOI 10.1038/sj.ijo.0801995
   Wortmann RL, 2002, CURR OPIN RHEUMATOL, V14, P281, DOI 10.1097/00002281-200205000-00015
   Yiginer O, 2008, CLIN RES CARDIOL, V97, P334, DOI 10.1007/s00392-007-0636-3
   Yokota T, 2000, BLOOD, V96, P1723, DOI 10.1182/blood.V96.5.1723
   Yoo TW, 2005, CIRC J, V69, P928, DOI 10.1253/circj.69.928
   Youssef F, 2004, ANGIOLOGY, V55, P53, DOI 10.1177/000331970405500108
   ZAVARONI I, 1993, J INTERN MED, V234, P25, DOI 10.1111/j.1365-2796.1993.tb00700.x
NR 103
TC 32
Z9 36
U1 1
U2 26
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1472-8222
EI 1744-7631
J9 EXPERT OPIN THER TAR
JI Expert Opin. Ther. Targets
PD DEC
PY 2012
VL 16
IS 12
BP 1175
EP 1187
DI 10.1517/14728222.2012.723694
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 039HM
UT WOS:000311235400004
PM 23020656
DA 2025-06-11
ER

PT J
AU Jones, EJ
   Feinberg, ME
   Graham-Engeland, JE
   Jones, DE
   Schreier, HMC
AF Jones, Emily J.
   Feinberg, Mark E.
   Graham-Engeland, Jennifer E.
   Jones, Damon E.
   Schreier, Hannah M. C.
TI A perinatal coparenting intervention: Effects of a randomized trial on
   parent cardiometabolic risk and self-reported health
SO BIOLOGICAL PSYCHOLOGY
LA English
DT Article
DE Coparenting; Intervention; Cholesterol; Self-rated health; Inflammation
ID C-REACTIVE PROTEIN; DRIED BLOOD SPOTS; CARDIOVASCULAR-DISEASE; RATED
   HEALTH; SYSTEMIC INFLAMMATION; POSTPARTUM DEPRESSION; FAMILY
   FOUNDATIONS; METABOLIC SYNDROME; MARITAL CONFLICT; AFRICAN-AMERICAN
AB Background: The transition to parenthood is a common yet stressful experience faced by many young and midlife adults, and the risk of cardiometabolic conditions also begins to rise at this time. Consequently, parenthood represents an opportune time to intervene with adults to support their psychological and physical health.
   Purpose: We examined whether the benefits of the Family Foundations program, a perinatal preventative intervention promoting positive coparenting, extend beyond documented mental health and family relationship outcomes to better cardiometabolic risk factors among parents.
   Methods: We analyzed data from 183 couples (n = 366 participants) who, eight years prior, were randomly assigned to the 9-session perinatal preventative intervention program or a control condition. We collected dried blood spots to measure C-reactive protein (CRP), interleukin-6 (IL-6), and cholesterol; parents also reported on their self-rated health.
   Results: Randomization to the intervention condition was associated with lower cholesterol (B=-.081, p =.049). Among parents who demonstrated more negative communication styles at pretest (during pregnancy), the intervention was further associated with better self-rated health (B=.181, p =.018). Participation in the intervention program was also marginally associated with lower CRP (B=-.261, p =.077), particularly among mothers (B=-.428, p =.076).
   Conclusions: These findings indicate that coparenting-focused interventions, such as Family Foundations, can lead to benefits beyond psychosocial and behavioral outcomes, and suggest that Family Foundations may improve parents' longer-term physical health, with potentially more benefits among couples who demonstrated more negative communication styles during pregnancy.
C1 [Jones, Emily J.] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15213 USA.
   [Feinberg, Mark E.] Penn State Univ, Edna Bennett Pierce Prevent Res Ctr, University Pk, PA 16802 USA.
   [Graham-Engeland, Jennifer E.; Schreier, Hannah M. C.] Penn State Univ, Dept Biobehav Hlth, University Pk, PA 16802 USA.
   [Schreier, Hannah M. C.] 219 Biobehav Hlth Bldg, University Pk, PA 16802 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); Pennsylvania State University; Pennsylvania State University -
   University Park; Penn State Behrend; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); Pennsylvania State University; Pennsylvania
   State University - University Park; Penn State Behrend
RP Schreier, HMC (corresponding author), 219 Biobehav Hlth Bldg, University Pk, PA 16802 USA.
EM hannah.schreier@psu.edu
FU National Heart, Lung, and Blood Institute [R01 HL137809]; Eunice Kennedy
   Shriver National Institute of Child Health & Human Development [R01
   HD058529, R01 HD084476]
FX Research reported in this manuscript was supported by funding from the
   National Heart, Lung, and Blood Institute (R01 HL137809 (Schreier)) and
   Eunice Kennedy Shriver National Institute of Child Health & Human
   Development (R01s HD058529 and HD084476 (Feinberg)).
CR Ammerman RT, 2022, J FAM PSYCHOL, V36, P225, DOI 10.1037/fam0000888
   Andersson C, 2018, NAT REV CARDIOL, V15, P230, DOI 10.1038/nrcardio.2017.154
   [Anonymous], 2017, Cardiovascular disease: A costly burden for America - Projections through 2035
   Bajaj A, 2016, BRAIN BEHAV IMMUN, V58, P152, DOI 10.1016/j.bbi.2016.06.004
   Cardenas SI, 2021, J CHILD FAM STUD, V30, P3080, DOI 10.1007/s10826-021-02139-3
   Christian LM, 2011, PSYCHONEUROENDOCRINO, V36, P1495, DOI 10.1016/j.psyneuen.2011.04.003
   Corso G, 2016, J CLIN LAB ANAL, V30, P517, DOI 10.1002/jcla.21890
   D'Agostino RB, 2013, GLOB HEART, V8, P11, DOI 10.1016/j.gheart.2013.01.001
   Darnall BD, 2009, BRAIN BEHAV IMMUN, V23, P595, DOI 10.1016/j.bbi.2009.02.019
   Deave Toity, 2008, BMC Pregnancy Childbirth, V8, P30, DOI 10.1186/1471-2393-8-30
   Doss BD, 2009, J PERS SOC PSYCHOL, V96, P601, DOI 10.1037/a0013969
   Duncan BB, 2003, DIABETES, V52, P1799, DOI 10.2337/diabetes.52.7.1799
   Farmer MM, 1997, J HEALTH SOC BEHAV, V38, P298, DOI 10.2307/2955372
   Feinberg M. E., 2015, FAMILY BASED PREVENT, P35
   Feinberg ME, 2022, FAM PROCESS, V61, P76, DOI 10.1111/famp.12730
   Feinberg ME, 2018, COUPLE FAM PSYCHOL, V7, P63, DOI 10.1037/cfp0000100
   Feinberg ME, 2014, J FAM PSYCHOL, V28, P821, DOI 10.1037/fam0000037
   Feinberg ME, 2003, PARENT-SCI PRACT, V3, P95, DOI 10.1207/S15327922PAR0302_01
   Feinberg ME, 2010, J FAM PSYCHOL, V24, P532, DOI 10.1037/a0020837
   Feinberg ME, 2002, CLIN CHILD FAM PSYCH, V5, P173, DOI 10.1023/A:1019695015110
   Gabay C, 1999, NEW ENGL J MED, V340, P448, DOI 10.1056/NEJM199902113400607
   Giallo R, 2022, FAM RELAT, V71, P1036, DOI 10.1111/fare.12647
   Glade AC, 2005, AM J FAM THER, V33, P319, DOI 10.1080/01926180590962138
   Graham J. W., 2012, Missing data: Analysis and design, DOI [10.1007/978-1-4614-4018-5, DOI 10.1007/978-1-4614-4018-5]
   Herder M, 2012, STROKE, V43, P1818, DOI 10.1161/STROKEAHA.111.646596
   Irwin MR, 2016, BIOL PSYCHIAT, V80, P40, DOI 10.1016/j.biopsych.2015.05.014
   Jones DE, 2018, FAM RELAT, V67, P270, DOI 10.1111/fare.12309
   Joseph NT, 2014, PSYCHOSOM MED, V76, P347, DOI 10.1097/PSY.0000000000000071
   Kiecolt-Glaser JK, 2010, NEUROSCI BIOBEHAV R, V35, P33, DOI 10.1016/j.neubiorev.2009.09.003
   KiecoltGlaser JK, 1997, PSYCHOSOM MED, V59, P339, DOI 10.1097/00006842-199707000-00001
   Klein BEK, 2002, DIABETES CARE, V25, P1790, DOI 10.2337/diacare.25.10.1790
   Kluwer E.S., 2010, Journal of Family Theory and Review, V2, P105, DOI [10.1111/j.1756-2589.2010.00045.x, DOI 10.1111/J.1756-2589.2010.00045.X]
   Lakshmy R, 2012, J CLIN LIPIDOL, V6, P33, DOI 10.1016/j.jacl.2011.10.021
   Lévesque S, 2020, J CHILD FAM STUD, V29, P1938, DOI 10.1007/s10826-020-01727-z
   Lewin A, 2015, J PRIM PREV, V36, P139, DOI 10.1007/s10935-015-0388-1
   Livingston Gretchen., 2018, The Changing Profile of Unmarried Parents
   Mauer J, 2015, TRENDS IMMUNOL, V36, P92, DOI 10.1016/j.it.2014.12.008
   Mavaddat N, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0103509
   Mcdade TW, 2007, DEMOGRAPHY, V44, P899, DOI 10.1353/dem.2007.0038
   McDade TW, 2021, AM J HUM BIOL, V33, DOI 10.1002/ajhb.23558
   McDade TW, 2004, CLIN CHEM, V50, P652, DOI 10.1373/clinchem.2003.029488
   McLeod GFH, 2016, SOC PSYCH PSYCH EPID, V51, P1385, DOI 10.1007/s00127-016-1254-z
   Michopoulos V, 2017, NEUROPSYCHOPHARMACOL, V42, P254, DOI 10.1038/npp.2016.146
   Miller GE, 2014, P NATL ACAD SCI USA, V111, P11287, DOI 10.1073/pnas.1406578111
   Nelson SK, 2014, PSYCHOL BULL, V140, P846, DOI 10.1037/a0035444
   Noh JW, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-40090-y
   Nomaguchi KM, 2003, J MARRIAGE FAM, V65, P356, DOI 10.1111/j.1741-3737.2003.00356.x
   O'Connor DB, 2009, ANN BEHAV MED, V37, P184, DOI 10.1007/s12160-009-9087-6
   Paulson JF, 2006, PEDIATRICS, V118, P659, DOI 10.1542/peds.2005-2948
   Paulson JF, 2010, JAMA-J AM MED ASSOC, V303, P1961, DOI 10.1001/jama.2010.605
   de Heredia FP, 2012, P NUTR SOC, V71, P332, DOI 10.1017/S0029665112000092
   Prosper MH, 2009, AM J HEALTH BEHAV, V33, P319
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Ridker PM, 2000, NEW ENGL J MED, V342, P836, DOI 10.1056/NEJM200003233421202
   Rohleder N, 2014, PSYCHOSOM MED, V76, P181, DOI 10.1097/PSY.0000000000000049
   SAS Institutes Inc S, 2011, SAS/STAT 9.3 user's guide
   Saxbe D, 2018, AM PSYCHOL, V73, P1190, DOI 10.1037/amp0000376
   Schreier HMC, 2013, JAMA PEDIATR, V167, P327, DOI 10.1001/jamapediatrics.2013.1100
   Shanahan L, 2014, BRAIN BEHAV IMMUN, V36, P139, DOI 10.1016/j.bbi.2013.10.020
   Sharma A, 2014, DRUG TEST ANAL, V6, P399, DOI 10.1002/dta.1646
   Slep AMS, 2005, J CONSULT CLIN PSYCH, V73, P435, DOI 10.1037/0022-006X.73.3.435
   Staland-Nyman C, 2008, SCAND J PUBLIC HEALT, V36, P21, DOI 10.1177/1403494807085307
   StataCorp, 2016, Stata Statistical Software
   Takeishi Y, 2019, TOHOKU J EXP MED, V249, P9, DOI 10.1620/tjem.249.9
   Toss F, 2013, AM HEART J, V165, P164, DOI 10.1016/j.ahj.2012.10.030
   Troxel WM, 2003, HEALTH PSYCHOL, V22, P300, DOI 10.1037/0278-6133.22.3.300
   Villalba DK, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0219120
   Vitaliano PP, 2002, PSYCHOSOM MED, V64, P418, DOI 10.1097/00006842-200205000-00006
   Washington State Institute for Public Policy, 2020, Triple P-Positive Parenting Program (System). Public Health & Prevention: Population-level policies
   Whisman MA, 2012, J FAM PSYCHOL, V26, P290, DOI 10.1037/a0026902
   Wilson SJ, 2017, PSYCHONEUROENDOCRINO, V79, P74, DOI 10.1016/j.psyneuen.2017.02.015
   Wirtz PH, 2017, CURR CARDIOL REP, V19, DOI 10.1007/s11886-017-0919-x
NR 72
TC 1
Z9 1
U1 1
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0301-0511
EI 1873-6246
J9 BIOL PSYCHOL
JI Biol. Psychol.
PD OCT
PY 2023
VL 183
AR 108664
DI 10.1016/j.biopsycho.2023.108664
EA AUG 2023
PG 10
WC Psychology, Biological; Behavioral Sciences; Psychology; Psychology,
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA S2VL8
UT WOS:001069798700001
PM 37625684
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Nicolson, GL
AF Nicolson, Garth L.
TI Metabolic syndrome and mitochondrial function: Molecular replacement and
   antioxidant supplements to prevent membrane peroxidation and restore
   mitochondrial function
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Review
DE lipids; antioxidants; diabetes; atherosclerosis; vascular inflammation;
   heart disease; renal disease; liver disease; dietary supplement;
   mitochondria; fatigue
ID C-REACTIVE PROTEIN; 3RD NATIONAL-HEALTH; ENDOTHELIUM-DEPENDENT
   VASODILATION; INSULIN-RESISTANCE SYNDROME; TYPE-2 DIABETES-MELLITUS;
   FATTY-ACID TRANSPORT; OXIDATIVE STRESS; CHRONIC-FATIGUE;
   SKELETAL-MUSCLE; NITRIC-OXIDE
AB Metabolic syndrome consists of a cluster of metabolic conditions, such as hypertriglyeridemia, hyperlow-density lipoproteins, hypo-high-density lipoproteins, insulin resistance, abnormal glucose tolerance and hypertension, that-in combination with genetic susceptibility and abdominal obesity-are risk factors for type 2 diabetes, vascular inflammation, atherosclerosis, and renal, liver and heart disease. One of the defects in metabolic syndrome and its associated diseases is excess cellular oxidative stress (mediated by reactive oxygen and nitrogen species, ROS/RNS) and oxidative damage to mitochondrial components, resulting in reduced efficiency of the electron transport chain. Recent evidence indicates that reduced mitochondrial function caused by ROS/RNS membrane oxidation is related to fatigue, a common complaint of MS patients. Lipid replacement therapy (LRT) administered as a nutritional supplement with antioxidants can prevent excess oxidative membrane damage, restore mitochondrial and other cellular membrane functions and reduce fatigue. Recent clinical trials have shown the benefit of LRT plus antioxidants in restoring mitochondrial electron transport function and reducing moderate to severe chronic fatigue. Thus LRT plus antioxidant supplements should be considered for metabolic syndrome patients who suffer to various degrees from fatigue. J. Cell. Biochem. 100: 1352-1369, 2007. (c) 2007 Wiley-Liss, Inc.
C1 Inst Mol Med, Off President, Dept Mol Pathol, Huntington Beach, CA 92647 USA.
RP Nicolson, GL (corresponding author), Inst Mol Med, Off President, Dept Mol Pathol, 16371 Gothard St H, Huntington Beach, CA 92647 USA.
EM gnicolson@immed.org
CR Afridi I, 2003, J HYPERTENS, V21, P1983, DOI 10.1097/01.hjh.0000084751-37215.d2
   Agadjanyan M., 2003, Journal of Chronic Fatigue Syndrome, V11, P23, DOI [DOI 10.1300/J092V11N03_03, 10.1300/J092v11n03_03, DOI 10.1300/J092V11N0303]
   Al Aly Z, 2004, ADV CHRONIC KIDNEY D, V11, P310, DOI 10.1053/j.arrt.2004.04.006
   AMES BM, 1998, TOXICOL LETT, V102, P1035
   Arivazhagan P, 2001, CHEM-BIOL INTERACT, V138, P189, DOI 10.1016/S0009-2797(01)00268-X
   BARKER DJP, 1993, DIABETOLOGIA, V36, P62, DOI 10.1007/BF00399095
   Baynes JW, 1999, DIABETES, V48, P1, DOI 10.2337/diabetes.48.1.1
   BECKMAN JS, 1990, P NATL ACAD SCI USA, V87, P1620, DOI 10.1073/pnas.87.4.1620
   Bergandi L, 2003, ARTERIOSCL THROM VAS, V23, P2215, DOI 10.1161/01.ATV.0000107028.20478.8e
   Berliner JA, 2005, NEW ENGL J MED, V353, P9, DOI 10.1056/NEJMp058118
   Bhargava SK, 2004, NEW ENGL J MED, V350, P865, DOI 10.1056/NEJMoa035698
   Blaak EE, 2003, P NUTR SOC, V62, P753, DOI 10.1079/PNS2003290
   Bonora E, 2003, INT J OBESITY, V27, P1283, DOI 10.1038/sj.ijo.0802381
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Bugianesi E, 2005, DIABETOLOGIA, V48, P634, DOI 10.1007/s00125-005-1682-x
   Butler AE, 2003, DIABETES, V52, P102, DOI 10.2337/diabetes.52.1.102
   CASTRO L, 1994, J BIOL CHEM, V269, P29409
   Ceriello A, 2003, DIABETES CARE, V26, P1589, DOI 10.2337/diacare.26.5.1589
   CHAIT A, 1993, AM J MED, V94, P350, DOI 10.1016/0002-9343(93)90144-E
   Chakraborty C, 2006, CURR PROTEIN PEPT SC, V7, P113, DOI 10.2174/138920306776359759
   Chen DX, 2002, J NEUROCHEM, V81, P1273, DOI 10.1046/j.1471-4159.2002.00916.x
   Cifkova R, 2003, J Hypertens, V21, P1779
   Collantes RS, 2006, PANMINERVA MED, V48, P41
   COLLINS T, 1993, LAB INVEST, V68, P499
   Colomé C, 2000, ATHEROSCLEROSIS, V149, P295, DOI 10.1016/S0021-9150(99)00338-X
   Conner SD, 2003, NATURE, V422, P37, DOI 10.1038/nature01451
   Cusi K, 2000, J CLIN INVEST, V105, P311, DOI 10.1172/JCI7535
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   DE AK, 1991, MECH AGEING DEV, V59, P123, DOI 10.1016/0047-6374(91)90078-E
   Doi H, 2000, CIRCULATION, V102, P670, DOI 10.1161/01.CIR.102.6.670
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Einhorn Daniel, 2003, Endocr Pract, V9, P237
   Ellithorpe RR., 2003, J AM NUTRACEUTICAL A, V6, P23
   Faggin E, 2002, J AM COLL CARDIOL, V40, P1059, DOI 10.1016/S0735-1097(02)02116-2
   Farvid MS, 2004, J AM COLL NUTR, V23, P272, DOI 10.1080/07315724.2004.10719370
   Fellmann P, 2000, BIOCHEMISTRY-US, V39, P4994, DOI 10.1021/bi992649q
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Flatt PR, 2006, BIOCHEM SOC T, V34, P774, DOI 10.1042/BST0340774
   Fonseca Vivian A, 2005, Clin Cornerstone, V7, P61, DOI 10.1016/S1098-3597(05)80069-9
   Ford ES, 2003, ATHEROSCLEROSIS, V168, P351, DOI 10.1016/S0021-9150(03)00134-5
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Fulle S, 2000, FREE RADICAL BIO MED, V29, P1252, DOI 10.1016/S0891-5849(00)00419-6
   Goldstein BJ, 2005, DIABETES, V54, P311, DOI 10.2337/diabetes.54.2.311
   GOTAH T, 2006, ARTERIOSCLER THROMB, V26, P1439
   Granot E, 2004, CLIN NUTR, V23, P3, DOI 10.1016/S0261-5614(03)00097-9
   Green K, 2004, DIABETES, V53, pS110, DOI 10.2337/diabetes.53.2007.S110
   Griendling KK, 2000, ARTERIOSCL THROM VAS, V20, P2175, DOI 10.1161/01.ATV.20.10.2175
   Grundy SM, 2006, AM J CLIN NUTR, V83, P1248, DOI 10.1093/ajcn/83.6.1248
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Hagen T, 2002, Minerva Med, V93, P41
   Hajri T, 2002, ANNU REV NUTR, V22, P383, DOI 10.1146/annurev.nutr.22.020402.130846
   Hall JE, 2003, CURR HYPERTENS REP, V5, P386, DOI 10.1007/s11906-003-0084-z
   Halliwell B, 1999, FREE RADICAL RES, V31, P261, DOI 10.1080/10715769900300841
   Halliwell B, 2001, DRUG AGING, V18, P685, DOI 10.2165/00002512-200118090-00004
   Hamilton JA, 1998, J LIPID RES, V39, P467
   HARMAN D, 1956, J GERONTOL, V11, P298, DOI 10.1093/geronj/11.3.298
   Harrison Stephen A, 2006, Curr Gastroenterol Rep, V8, P21, DOI 10.1007/s11894-006-0060-2
   Hayden MR, 2005, CARDIOVASC DIABETOL, V4, DOI 10.1186/1475-2840-4-9
   Hayden Melvin R, 2006, J Cardiometab Syndr, V1, P16, DOI 10.1111/j.0197-3118.2006.05454.x
   Hayden MR, 2005, J PANCREAS, V6, P287
   Hayden MR, 2005, CARDIOVASC DIABETOL, V4, DOI 10.1186/1475-2840-4-4
   Hayden Melvin R, 2003, Med Sci Monit, V9, pSR35
   HEINRICH PC, 1990, BIOCHEM J, V265, P621, DOI 10.1042/bj2650621
   Heitzer T, 1996, CIRCULATION, V94, P6, DOI 10.1161/01.CIR.94.1.6
   Hotamisligil GS, 1996, SCIENCE, V271, P665, DOI 10.1126/science.271.5249.665
   Houston M.C., 2005, J AM NUTRACEUTICAL A, V8, P3
   Houston MC, 2005, PROG CARDIOVASC DIS, V47, P396, DOI 10.1016/j.pcad.2005.01.004
   Hsueh WA, 2003, AM J CARDIOL, V92, p10J, DOI 10.1016/S0002-9149(03)00611-8
   Huang H, 2004, FRONT BIOSCI-LANDMRK, V9, P1100, DOI 10.2741/1298
   Irani K, 2000, CIRC RES, V87, P179, DOI 10.1161/01.RES.87.3.179
   Itani SI, 2002, DIABETES, V51, P2005, DOI 10.2337/diabetes.51.7.2005
   Jaquet D, 2000, J CLIN ENDOCR METAB, V85, P1401, DOI 10.1210/jc.85.4.1401
   Kahn SE, 1999, DIABETES, V48, P241, DOI 10.2337/diabetes.48.2.241
   Kanno T, 2004, FREE RADICAL RES, V38, P27, DOI 10.1080/10715760310001626266
   Keenoy BHY, 2000, J AM COLL NUTR, V19, P374, DOI 10.1080/07315724.2000.10718934
   Keenoy BMY, 2001, LIFE SCI, V68, P2037, DOI 10.1016/S0024-3205(01)01001-3
   KELLEY DE, 1994, J CLIN INVEST, V94, P2349, DOI 10.1172/JCI117600
   Kelley DE, 2002, DIABETES, V51, P2944, DOI 10.2337/diabetes.51.10.2944
   Kendall DM, 2003, CORONARY ARTERY DIS, V14, P335, DOI 10.1097/01.mca.0000076512.29238.2a
   Kopitz J, 2004, BIOCHIMIE, V86, P825, DOI 10.1016/j.biochi.2004.09.029
   KROENKE K, 1988, JAMA-J AM MED ASSOC, V260, P929, DOI 10.1001/jama.260.7.929
   Krssak M, 1999, DIABETOLOGIA, V42, P113, DOI 10.1007/s001250051123
   Kylin E., 1923, Zentralbl Inn Med, V44, P105
   LAGENFELD MR, 2004, DIABETES TECHNOL THE, V6, P836
   Leppälä JM, 2000, ARTERIOSCL THROM VAS, V20, P230, DOI 10.1161/01.ATV.20.1.230
   Levey AS, 1998, AM J KIDNEY DIS, V32, P853, DOI 10.1016/S0272-6386(98)70145-3
   Libby P, 2002, NATURE, V420, P868, DOI 10.1161/ATVBAHA.108.179705
   Linnane AW, 2006, ANN NY ACAD SCI, V1067, P47, DOI 10.1196/annals.1354.008
   Logan A C, 2001, Altern Med Rev, V6, P450
   MACHLIN LJ, 1987, FASEB J, V1, P441, DOI 10.1096/fasebj.1.6.3315807
   Manning RD, 2005, AM J NEPHROL, V25, P311, DOI 10.1159/000086411
   Mansbach CM, 2000, J LIPID RES, V41, P605
   MCDONALD E, 1993, PSYCHOL MED, V23, P987, DOI 10.1017/S0033291700026453
   Mensink M, 2003, INT J OBESITY, V27, P377, DOI 10.1038/sj.ijo.0802249
   Mikhail N, 2000, Curr Hypertens Rep, V2, P148
   MIQUEL J, 2002, ANN NY ACAD SCI, V959, P317
   MITCHELL P, 1966, BIOL REV, V41, P445, DOI 10.1111/j.1469-185X.1966.tb01501.x
   Morris BW, 1999, J TRACE ELEM MED BIO, V13, P57, DOI 10.1016/S0946-672X(99)80024-8
   MORRISON JD, 1980, J FAM PRACTICE, V10, P795
   Ndumele Chiadi E, 2006, J Cardiometab Syndr, V1, P190
   Nicolson G L., 2006, Journal of Chronic Fatigue Syndrome, V13, P57, DOI 10.1300/J092v13n01_06
   Nicolson GL, 2005, PATHOL ONCOL RES, V11, P139, DOI 10.1007/BF02893390
   Nicolson GL, 2003, Journal of the American Nutraceutical Association, V6, P22
   NICOLSON GL, 1977, CELL SURF REV, V3, P1
   Opara EC, 2004, J INVEST MED, V52, P19, DOI 10.1136/jim-52-01-22
   Opara EC, 2002, J R SOC PROMO HEALTH, V122, P28, DOI 10.1177/146642400212200112
   Pall ML, 2000, MED HYPOTHESES, V54, P115, DOI 10.1054/mehy.1998.0825
   Paolisso G, 1999, DIABETES METAB, V25, P298
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Pasceri V, 2000, CIRCULATION, V102, P2165
   Pasternak Richard C., 2003, Cardiology Clinics, V21, P393, DOI 10.1016/S0733-8651(03)00080-8
   Perseghin G, 1999, DIABETES, V48, P1600, DOI 10.2337/diabetes.48.8.1600
   Perseghin G, 2003, INT J OBESITY, V27, pS6, DOI 10.1038/sj.ijo.0802491
   Pessayre D, 2005, J HEPATOL, V42, P928, DOI 10.1016/j.jhep.2005.03.004
   PESSAYRE D, 2004, EUR J GASTROEN HEPAT, V16, P1
   Pessin JE, 2000, J CLIN INVEST, V106, P165, DOI 10.1172/JCI10582
   Petersen KF, 2003, SCIENCE, V300, P1140, DOI 10.1126/science.1082889
   Piper B F, 1987, Oncol Nurs Forum, V14, P17
   PIPER BF, 1988, ONCOL NURS FORUM, V25, P667
   Preuss HG, 1998, J AM COLL NUTR, V17, P101, DOI 10.1080/07315724.1998.10718732
   RADI R, 1994, ARCH BIOCHEM BIOPHYS, V308, P89, DOI 10.1006/abbi.1994.1013
   Raz I, 2005, DIABETES-METAB RES, V21, P3, DOI 10.1002/dmrr.493
   Reaven GM, 2006, AM J CLIN NUTR, V83, P1237, DOI 10.1093/ajcn/83.6.1237
   REAVEN GM, 1993, ANNU REV MED, V44, P121, DOI 10.1146/annurev.med.44.1.121
   Richards RS, 2000, REDOX REP, V5, P35, DOI 10.1179/rer.2000.5.1.35
   RICHTER C, 1988, P NATL ACAD SCI USA, V85, P6465, DOI 10.1073/pnas.85.17.6465
   Ridker PM, 2003, AM J CARDIOL, V92, p17K, DOI 10.1016/S0002-9149(03)00774-4
   Ridker PM, 2004, CIRCULATION, V109, P2818, DOI 10.1161/01.CIR.0000132467.45278.59
   Rösen P, 2001, DIABETES-METAB RES, V17, P189, DOI 10.1002/dmrr.196
   RUSSELL AP, 2003, J CLIN INVEST, V111, P479
   SCHNEIDER SH, 1984, DIABETOLOGIA, V26, P355, DOI 10.1007/BF00266036
   Schrauwen P, 2004, DIABETES, V53, P1412, DOI 10.2337/diabetes.53.6.1412
   Schrauwen P, 2002, CURR OPIN CLIN NUTR, V5, P265, DOI 10.1097/00075197-200205000-00005
   Schrauwen P, 2001, DIABETES, V50, P2870, DOI 10.2337/diabetes.50.12.2870
   Seidman MD, 2002, OTOLARYNG HEAD NECK, V127, P138, DOI 10.1067/mhn.2002.127627
   Sharman EH, 2001, NEUROBIOL AGING, V22, P629, DOI 10.1016/S0197-4580(01)00226-3
   Shepherd PR, 1998, BIOCHEM J, V333, P471, DOI 10.1042/bj3330471
   Sheu SS, 2006, BBA-MOL BASIS DIS, V1762, P256, DOI 10.1016/j.bbadis.2005.10.007
   Shoelson SE, 2003, INT J OBESITY, V27, pS49, DOI 10.1038/sj.ijo.0802501
   Sima AAF, 2006, CURR OPIN INVEST DR, V7, P324
   Simmons RA, 2006, FREE RADICAL BIO MED, V40, P917, DOI 10.1016/j.freeradbiomed.2005.12.018
   Smith RAJ, 2003, P NATL ACAD SCI USA, V100, P5407, DOI 10.1073/pnas.0931245100
   Sonnenberg GE, 2004, OBES RES, V12, P180, DOI 10.1038/oby.2004.24
   Sowers JR, 2004, MED CLIN N AM, V88, P63, DOI 10.1016/S0025-7125(03)00128-7
   St-Pierre J, 2005, CAN J CARDIOL, V21, P199
   STRAIN JJ, 1991, P NUTR SOC, V50, P591, DOI 10.1079/PNS19910073
   Subczynski WK, 2000, ACTA BIOCHIM POL, V47, P613, DOI 10.18388/abp.2000_3983
   Sugiyama S, 1995, BIOCHEM MOL BIOL INT, V37, P1111
   Sullivan PG, 2004, J BIOENERG BIOMEMBR, V36, P353, DOI 10.1023/B:JOBB.0000041767.30992.19
   Szeto HH, 2006, AAPS J, V8, pE277, DOI 10.1007/BF02854898
   Ting HH, 1996, J CLIN INVEST, V97, P22, DOI 10.1172/JCI118394
   Ting HH, 1997, CIRCULATION, V95, P2617, DOI 10.1161/01.CIR.95.12.2617
   Touyz RM, 2004, HISTOCHEM CELL BIOL, V122, P339, DOI 10.1007/s00418-004-0696-7
   Turrens JF, 2003, J PHYSIOL-LONDON, V552, P335, DOI 10.1113/jphysiol.2003.049478
   Ueda S, 2006, CURR PHARM BIOTECHNO, V7, P69, DOI 10.2174/138920106776597649
   Uittenbogaard A, 2000, J BIOL CHEM, V275, P11278, DOI 10.1074/jbc.275.15.11278
   van Reyk DM, 2003, REDOX REP, V8, P187, DOI 10.1179/135100003225002673
   Vechoor V.K., 2002, P NATL ACAD SCI USA, V99, P1087
   Vidal-Puig AJ, 2000, J BIOL CHEM, V275, P16258, DOI 10.1074/jbc.M910179199
   Visser M, 1999, JAMA-J AM MED ASSOC, V282, P2131, DOI 10.1001/jama.282.22.2131
   Vitarius JA, 2005, MT SINAI J MED, V72, P257
   Von Roenn JH, 2005, SEMIN ONCOL, V32, P200, DOI 10.1053/j.seminoncol.2004.11.019
   Wei YH, 2002, EXP BIOL MED, V227, P671, DOI 10.1177/153537020222700901
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Wilcox CS, 2005, AM J PHYSIOL-REG I, V289, pR913, DOI 10.1152/ajpregu.00250.2005
   Wolk R, 2003, HYPERTENSION, V42, P1067, DOI 10.1161/01.HYP.0000101686.98973.A3
   Xu D, 2002, BIOCHEM BIOPH RES CO, V294, P245, DOI 10.1016/S0006-291X(02)00464-3
   Zambon A, 2005, ALIMENT PHARM THER, V22, P20, DOI 10.1111/j.1365-2036.2005.02589.x
   Zeng GY, 2000, CIRCULATION, V101, P1539, DOI 10.1161/01.CIR.101.13.1539
   Zwaka TP, 2001, CIRCULATION, V103, P1194
NR 170
TC 76
Z9 103
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-2312
EI 1097-4644
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD APR 15
PY 2007
VL 100
IS 6
BP 1352
EP 1369
DI 10.1002/jcb.21247
PG 18
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 152ZF
UT WOS:000245400300003
PM 17243117
DA 2025-06-11
ER

PT J
AU Nysather, J
   Kaya, E
   Manka, P
   Gudsoorkar, P
   Syn, WK
AF Nysather, Jacob
   Kaya, Eda
   Manka, Paul
   Gudsoorkar, Prakash
   Syn, Wing-Kin
TI Nonalcoholic Fatty Liver Disease and Chronic Kidney Disease Cross Talk
SO ADVANCES IN KIDNEY DISEASE AND HEALTH
LA English
DT Article
DE Nonalcoholic fatty liver disease (NAFLD); Nonalcoholic steatohepatitis
   (NASH); Chronic kidney disease (CKD); Meta-bolic syndrome
ID ENDOPLASMIC-RETICULUM STRESS; FETUIN-A; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; GUT MICROBIOTA; RISK-FACTORS; WEIGHT-LOSS;
   HEPATOCELLULAR-CARCINOMA; ENDOTHELIAL DYSFUNCTION; AMERICAN ASSOCIATION
AB Nonalcoholic fatty liver disease is a multisystem condition with effects beyond the liver. The identification of chronic kidney disease as an independent mediator of nonalcoholic fatty liver disease or associated entity with shared cardiometabolic risk factors remains controversial and continues to draw scientific interest. With increasing prevalence of nonalcoholic fatty liver disease and lack of Food and Drug Administration approved therapies, these shared cardiometabolic risk factors have drawn significant attention. In this article, we review shared pathophysiological mechanisms between nonalcoholic fatty liver disease and chronic kidney disease along with current treatment strategies that might be useful for both disease processes.& COPY; 2023 by the National Kidney Foundation, Inc. All rights reserved.
C1 [Nysather, Jacob; Gudsoorkar, Prakash] Univ Cincinnati, Div Nephrol, Cincinnati, OH USA.
   [Nysather, Jacob; Gudsoorkar, Prakash] Univ Cincinnati, Kidney CARE Program, Cincinnati, OH USA.
   [Kaya, Eda; Manka, Paul] Ruhr Univ Bochum, Univ Hosp Knappschaftskrankenhaus Bochum, Dept Internal Med, Bochum, Germany.
   [Syn, Wing-Kin] St Louis Univ, Sch Med, Div Gastroenterol & Hepatol, St Louis, MO USA.
   [Syn, Wing-Kin] Med Univ South Carolina, Div Gastroenterol & Hepatol, Charleston, SC USA.
   [Syn, Wing-Kin] Univ Basque Country, Euskal Herriko Unibertsitatea Univ Pais Vasco, Fac Med & Nursing, Dept Physiol, Leioa, Spain.
C3 University System of Ohio; University of Cincinnati; University System
   of Ohio; University of Cincinnati; Ruhr University Bochum; Saint Louis
   University; Medical University of South Carolina; University of Basque
   Country
RP Syn, WK (corresponding author), St Louis Univ, Sch Med, Liver Ctr, Gastroenterol & Hepatol, St Louis, MO 63104 USA.; Syn, WK (corresponding author), Med Univ South Carolina, Charleston, SC 29425 USA.
EM wingkin.syn@health.slu.edu
RI Syn, Wing-Kin/AAB-8406-2020; Manka, Paul/ABH-2421-2020; Kaya,
   Eda/AAN-9567-2020
OI Manka, Paul/0000-0001-8589-7280; Nysather, Jacob/0000-0003-1687-1129;
   Gudsoorkar, Prakash/0000-0001-9044-6054; Kaya, Eda/0000-0002-9293-2811
CR Abd El-Kader MS, 2013, AFR HEALTH SCI, V13, P682, DOI 10.4314/ahs.v13i3.23
   Abdel-Maboud M, 2020, THER ADV GASTROENTER, V13, DOI 10.1177/1756284820974917
   Abdelmalek MF, 2010, HEPATOLOGY, V51, P1961, DOI 10.1002/hep.23535
   Ahn AL, 2013, KOREAN J FAM MED, V34, P199, DOI 10.4082/kjfm.2013.34.3.199
   Akuta N, 2020, INTERNAL MED, V59, P1931, DOI 10.2169/internalmedicine.4398-19
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Ampuero J, 2018, ALIMENT PHARM THER, V48, P1260, DOI 10.1111/apt.15015
   Anstee QM, 2016, GASTROENTEROLOGY, V150, P1728, DOI 10.1053/j.gastro.2016.01.037
   Arai T, 2021, THER ADV ENDOCRINOL, V12, DOI 10.1177/20420188211000243
   Arase Y, 2011, INTERNAL MED, V50, P1081, DOI 10.2169/internalmedicine.50.5043
   Armstrong MJ, 2016, LANCET, V387, P679, DOI 10.1016/S0140-6736(15)00803-X
   Bahceci M, 2007, J ENDOCRINOL INVEST, V30, P210, DOI 10.1007/BF03347427
   Baratta F, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10030720
   Bizino MB, 2020, DIABETOLOGIA, V63, P65, DOI 10.1007/s00125-019-05021-6
   Caglar K, 2008, NEPHRON CLIN PRACT, V108, pC233, DOI 10.1159/000120209
   Cai JJ, 2020, CIRC RES, V126, P679, DOI 10.1161/CIRCRESAHA.119.316337
   Cao Y, 2021, THER ADV CHRONIC DIS, V12, DOI 10.1177/20406223211048649
   Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI 10.1002/hep.29367
   Chalasani N, 2012, GASTROENTEROLOGY, V142, P1592, DOI 10.1053/j.gastro.2012.04.001
   Chang AR, 2020, KIDNEY MED, V2, P699, DOI 10.1016/j.xkme.2020.08.008
   Chang Y, 2008, METABOLISM, V57, P569, DOI 10.1016/j.metabol.2007.11.022
   Chapagain A, 2014, P NATL ACAD SCI USA, V111, P3817, DOI 10.1073/pnas.1312436111
   Chavez CP, 2022, J CLIN ENDOCR METAB, V107, P29, DOI 10.1210/clinem/dgab578
   Chehrehgosha H, 2021, DIABETES THER, V12, P843, DOI 10.1007/s13300-021-01011-3
   Cheungpasitporn W, 2014, NEPHROLOGY, V19, P791, DOI 10.1111/nep.12343
   Ciardullo S, 2021, AM J NEPHROL, V52, P666, DOI 10.1159/000518111
   Cusi K, 2022, ENDOCR PRACT, V28, P528, DOI 10.1016/j.eprac.2022.03.010
   Di Costanzo A, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20184444
   Di Costanzo A, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-21939-0
   Di Sessa A, 2022, J RENAL NUTR, V32, P670, DOI 10.1053/j.jrn.2022.01.007
   Dogru T, 2013, CLIN ENDOCRINOL, V78, P712, DOI 10.1111/j.1365-2265.2012.04460.x
   Donati B, 2016, HEPATOLOGY, V63, P787, DOI 10.1002/hep.28370
   Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI23621
   EASL, 2016, OBESITY FACTS, V9, P65, DOI [10.1159/000443344, 10.1007/s00125-016-3902-y, 10.1016/j.jhep.2015.11.004]
   Ertle J, 2011, INT J CANCER, V128, P2436, DOI 10.1002/ijc.25797
   Euh W, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.613389
   Everard A, 2014, REV ENDOCR METAB DIS, V15, P189, DOI 10.1007/s11154-014-9288-6
   Foster MC, 2011, HYPERTENSION, V58, P784, DOI 10.1161/HYPERTENSIONAHA.111.175315
   Fu SN, 2011, NATURE, V473, P528, DOI 10.1038/nature09968
   Fujiwara N, 2018, J HEPATOL, V68, P526, DOI 10.1016/j.jhep.2017.09.016
   Gaborit B, 2021, CARDIOVASC DIABETOL, V20, DOI 10.1186/s12933-021-01237-2
   Georgescu EF, 2007, J GASTROINTEST LIVER, V16, P39
   Gérard C, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00029
   Gremmel T, 2013, NEPHROL DIAL TRANSPL, V28, P2116, DOI 10.1093/ndt/gft103
   Gupte AA, 2013, CURR DIABETES REP, V13, P362, DOI 10.1007/s11892-013-0372-1
   Gutiérrez-Grobe Y, 2017, DIABETES METAB, V43, P332, DOI 10.1016/j.diabet.2017.02.007
   Han E, 2020, J CLIN MED, V9, DOI 10.3390/jcm9010259
   Harrison SA, 2022, NAT MED, V28, P1432, DOI 10.1038/s41591-022-01861-9
   Haukeland JW, 2012, EUR J ENDOCRINOL, V166, P503, DOI 10.1530/EJE-11-0864
   Hauner H, 2002, DIABETES-METAB RES, V18, pS10, DOI 10.1002/dmrr.249
   Hellmann M, 2012, TRENDS CARDIOVAS MED, V22, P197, DOI 10.1016/j.tcm.2012.07.020
   Henriksson E, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.601349
   Hickman IJ, 2004, GUT, V53, P413, DOI 10.1136/gut.2003.027581
   Hirano T, 2018, J ATHEROSCLER THROMB, V25, P771, DOI 10.5551/jat.RV17023
   Hong T, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/6889533
   Huang DIQ, 2021, NAT REV GASTRO HEPAT, V18, P223, DOI 10.1038/s41575-020-00381-6
   Huang YC, 2011, J BIOL CHEM, V286, P37085, DOI 10.1074/jbc.M111.290114
   Hwang ST, 2010, INTERN MED J, V40, P437, DOI 10.1111/j.1445-5994.2009.01979.x
   Hyogo H, 2008, METABOLISM, V57, P1711, DOI 10.1016/j.metabol.2008.07.030
   Islam MM, 2020, CANCERS, V12, DOI 10.3390/cancers12030671
   Ix JH, 2010, J AM SOC NEPHROL, V21, P406, DOI 10.1681/ASN.2009080820
   Jalali M, 2020, PHARMACOL RES, V159, DOI 10.1016/j.phrs.2020.104799
   Jang HR, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-23014-0
   Jegatheesan P, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030230
   Johnson RJ, 2009, ENDOCR REV, V30, P96, DOI 10.1210/er.2008-0033
   Jung CY, 2022, DIABETOLOGIA, V65, P518, DOI 10.1007/s00125-021-05627-9
   Kahl S, 2020, DIABETES CARE, V43, P298, DOI 10.2337/dc19-0641
   Kanbay M, 2022, EUR J CLIN INVEST, V52, DOI 10.1111/eci.13748
   Kaps L, 2020, UNITED EUR GASTROENT, V8, P942, DOI 10.1177/2050640620944098
   Kaya E, 2022, J CLIN TRANSL HEPATO, V10, P329, DOI 10.14218/JCTH.2021.00178
   Khoo J, 2019, LIVER INT, V39, P941, DOI 10.1111/liv.14065
   Kim KM, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-81959-1
   Koeth RA, 2013, NAT MED, V19, P576, DOI 10.1038/nm.3145
   Koutoukidis DA, 2019, JAMA INTERN MED, V179, P1262, DOI 10.1001/jamainternmed.2019.2248
   Kronenberg F, 2009, NAT REV NEPHROL, V5, P677, DOI 10.1038/nrneph.2009.173
   Kuchay MS, 2020, DIABETOLOGIA, V63, P2434, DOI 10.1007/s00125-020-05265-7
   Kurella M, 2005, J AM SOC NEPHROL, V16, P2134, DOI 10.1681/ASN.2005010106
   Kuro-o M, 2012, ADV EXP MED BIOL, V728, P25, DOI 10.1007/978-1-4614-0887-1_2
   Lanaspa MA, 2012, J BIOL CHEM, V287, P40732, DOI 10.1074/jbc.M112.399899
   Li GL, 2012, BIOCHEM MEDICA, V22, P92
   Li XK, 2019, FRONT MED-PRC, V13, P511, DOI 10.1007/s11684-019-0711-y
   Li Y, 2013, BIOMED REP, V1, P57, DOI 10.3892/br.2012.18
   Lim JS, 2010, NAT REV GASTRO HEPAT, V7, P251, DOI 10.1038/nrgastro.2010.41
   Liu WY, 2022, CLIN MOL HEPATOL, V28, P183
   Lu WX, 2016, GASTROENT RES PRACT, V2016, DOI 10.1155/2016/1459790
   Lu X, 2017, KIDNEY DIS-BASEL, V3, P15, DOI 10.1159/000452880
   Luukkonen PK, 2016, J HEPATOL, V64, P1167, DOI 10.1016/j.jhep.2016.01.002
   Machado MV, 2012, LIVER INT, V32, P241, DOI 10.1111/j.1478-3231.2011.02623.x
   Maiwall R, 2020, TRANSL GASTROENT HEP, V5, DOI 10.21037/tgh.2019.10.11
   Mantovani A, 2019, DIABETES METAB, V45, P480, DOI 10.1016/j.diabet.2019.01.011
   Mantovani A, 2021, GUT, V70, P962, DOI 10.1136/gutjnl-2020-322572
   Mantovani A, 2020, LIVER INT, V40, P1130, DOI 10.1111/liv.14419
   Mantovani A, 2018, METABOLISM, V79, P64, DOI 10.1016/j.metabol.2017.11.003
   Marcuccilli M, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17040562
   Martín-González C, 2019, ALCOHOL ALCOHOLISM, V54, P204, DOI 10.1093/alcalc/agz019
   Marx N, 2021, LANCET DIABETES ENDO, V9, P46, DOI 10.1016/S2213-8587(20)30343-0
   Marzuillo P, 2019, PEDIATR OBES, V14, DOI 10.1111/ijpo.12539
   Mizuiri Sonoo, 2015, World J Nephrol, V4, P74, DOI 10.5527/wjn.v4.i1.74
   Montani JP, 2004, INT J OBESITY, V28, pS58, DOI 10.1038/sj.ijo.0802858
   Morris EM, 2013, MOL CELL ENDOCRINOL, V378, P29, DOI 10.1016/j.mce.2012.04.013
   Musso G, 2015, HEPATOLOGY, V62, P658, DOI 10.1002/hep.27643
   Musso G, 2014, PLOS MED, V11, DOI 10.1371/journal.pmed.1001680
   Nakagawa T, 2020, J AM SOC NEPHROL, V31, P898, DOI 10.1681/ASN.2019101015
   Newsome PN, 2021, NEW ENGL J MED, V384, P1113, DOI 10.1056/NEJMoa2028395
   Nishi H, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071664
   Nishimiya N, 2021, INTERNAL MED, V60, P3391, DOI 10.2169/internalmedicine.7134-21
   Ohki T, 2012, SCI WORLD J, DOI 10.1100/2012/496453
   Oniki K, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0132640
   Önnerhag K, 2019, SCAND J GASTROENTERO, V54, P328, DOI 10.1080/00365521.2019.1583366
   Ou HY, 2012, ENDOCRINOLOGY, V153, P2974, DOI 10.1210/en.2011-2043
   Paik J, 2019, LIVER INT, V39, P342, DOI 10.1111/liv.13992
   Pal D, 2012, NAT MED, V18, P1279, DOI 10.1038/nm.2851
   Pan XY, 2022, ADV EXP MED BIOL, V1372, P119, DOI 10.1007/978-981-19-0394-6_9
   Panebianco C, 2017, CLIN EXP MED, V17, P269, DOI 10.1007/s10238-016-0438-x
   Park CW, 2011, CLIN TRANSPLANT, V25, pE606, DOI 10.1111/j.1399-0012.2011.01497.x
   Park H, 2019, J INTERN MED, V286, P711, DOI 10.1111/joim.12964
   Park JH, 2020, KOREAN J INTERN MED, V35, P1291, DOI 10.3904/kjim.2020.410
   Parker HM, 2012, J HEPATOL, V56, P944, DOI 10.1016/j.jhep.2011.08.018
   Pergola PE, 2011, NEW ENGL J MED, V365, P327, DOI 10.1056/NEJMoa1105351
   Pinto KRD, 2021, BRAZ J MED BIOL RES, V54, DOI [10.1590/1414-431X202010022, 10.1590/1414-431x202010022]
   Promrat K, 2010, HEPATOLOGY, V51, P121, DOI 10.1002/hep.23276
   Ramezani A, 2014, J AM SOC NEPHROL, V25, P657, DOI 10.1681/ASN.2013080905
   Romeo S, 2008, NAT GENET, V40, P1461, DOI 10.1038/ng.257
   Ruan XZ, 2009, NAT REV NEPHROL, V5, P713, DOI 10.1038/nrneph.2009.184
   Rysz J, 2021, TOXINS, V13, DOI 10.3390/toxins13040252
   Ryu S, 2007, CLIN CHEM, V53, P71, DOI 10.1373/clinchem.2006.078980
   Sansoè G, 2020, LIVER INT, V40, P18, DOI 10.1111/liv.14272
   Santos SHS, 2012, REGUL PEPTIDES, V178, P64, DOI 10.1016/j.regpep.2012.06.009
   Sarafidis PA, 2006, AM J NEPHROL, V26, P232, DOI 10.1159/000093632
   Satapathy SK, 2022, TRANSL GASTROENT HEP, V7, DOI 10.21037/tgh-2020-15
   Scorletti E, 2016, DIGEST DIS, V34, P11, DOI 10.1159/000447276
   Seko Y, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21010171
   Shankar A, 2011, J CLIN HYPERTENS, V13, P925, DOI 10.1111/j.1751-7176.2011.00548.x
   Sharma K, 2008, J CLIN INVEST, V118, P1645, DOI 10.1172/JCI32691
   Shen ZW, 2017, INT UROL NEPHROL, V49, P303, DOI 10.1007/s11255-016-1429-2
   Silva ACSE, 2017, WORLD J GASTROENTERO, V23, P3396, DOI 10.3748/wjg.v23.i19.3396
   Singh S, 2016, KIDNEY INT, V90, P985, DOI 10.1016/j.kint.2016.05.019
   Sirota JC, 2012, AM J NEPHROL, V36, P466, DOI 10.1159/000343885
   Sisti LG, 2018, PREV MED, V109, P82, DOI 10.1016/j.ypmed.2017.12.027
   Spoto B, 2016, AM J PHYSIOL-RENAL, V311, pF1087, DOI 10.1152/ajprenal.00340.2016
   Sriperumbuduri S, 2019, SYST REV-LONDON, V8, DOI 10.1186/s13643-019-1052-2
   Suk KT, 2019, EXPERT REV GASTROENT, V13, P193, DOI 10.1080/17474124.2019.1569513
   Sun DQ, 2020, DIABETES METAB, V46, P288, DOI 10.1016/j.diabet.2019.11.003
   Sun DQ, 2020, LIVER INT, V40, P107, DOI 10.1111/liv.14251
   Sun LJ, 2002, J BIOL CHEM, V277, P18919, DOI 10.1074/jbc.M110650200
   Syn WK, 2009, CLIN LIVER DIS, V13, P565, DOI 10.1016/j.cld.2009.07.003
   Takahashi H, 2022, HEPATOL COMMUN, V6, P120, DOI 10.1002/hep4.1696
   Tang WHW, 2015, CIRC RES, V116, P448, DOI 10.1161/CIRCRESAHA.116.305360
   Targher G, 2008, DIABETOLOGIA, V51, P444, DOI 10.1007/s00125-007-0897-4
   Targher G, 2012, DIABETIC MED, V29, P220, DOI 10.1111/j.1464-5491.2011.03427.x
   Targher G, 2010, DIABETOLOGIA, V53, P1341, DOI 10.1007/s00125-010-1720-1
   Targher G, 2019, HEPATOLOGY, V70, P142, DOI 10.1002/hep.30625
   Targher G, 2017, NAT REV NEPHROL, V13, P297, DOI 10.1038/nrneph.2017.16
   Targher G, 2014, AM J KIDNEY DIS, V64, P638, DOI 10.1053/j.ajkd.2014.05.019
   Targher G, 2014, DIABETES CARE, V37, P1729, DOI 10.2337/dc13-2704
   Targher G, 2010, NEW ENGL J MED, V363, P1341, DOI 10.1056/NEJMra0912063
   Theytaz F, 2014, NUTRIENTS, V6, P2632, DOI 10.3390/nu6072632
   Thomson SC, 2017, AM J PHYSIOL-RENAL, V313, pF854, DOI 10.1152/ajprenal.00258.2017
   Tian F, 2018, BIOSCIENCE REP, V38, DOI 10.1042/BSR20181304
   Truong E, 2022, CLIN LIVER DIS, V26, P213, DOI 10.1016/j.cld.2022.01.008
   Vadarlis A, 2021, J GASTROEN HEPATOL, V36, P311, DOI 10.1111/jgh.15221
   Vaziri ND, 2013, AM J NEPHROL, V37, P518, DOI 10.1159/000351171
   Wang LJ, 2019, MOLECULES, V24, DOI 10.3390/molecules24183390
   Wei YR, 2013, NUTR METAB, V10, DOI 10.1186/1743-7075-10-32
   Wieland A, 2015, ALIMENT PHARM THER, V42, P1051, DOI 10.1111/apt.13376
   Wong VWS, 2018, J GASTROEN HEPATOL, V33, P70, DOI 10.1111/jgh.13857
   Xanthopoulos A, 2019, JACC-HEART FAIL, V7, P87, DOI 10.1016/j.jchf.2018.10.007
   Xu DW, 2019, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01428
   Xu KY, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-01387-y
   Yang J, 2008, BIOCHEM BIOPH RES CO, V370, P248, DOI 10.1016/j.bbrc.2008.03.094
   Yang K, 2017, BLOOD, V129, P2667, DOI 10.1182/blood-2016-10-744060
   Yano K, 2020, DIAGNOSTICS, V10, DOI 10.3390/diagnostics10020086
   Yasui K, 2011, METABOLISM, V60, P735, DOI 10.1016/j.metabol.2010.07.022
   Yokohama K, 2016, INT J MOL MED, V38, P1499, DOI 10.3892/ijmm.2016.2766
   Yoneda M, 2021, BMJ OPEN DIAB RES CA, V9, DOI 10.1136/bmjdrc-2020-001990
   Younossi Z, 2019, HEPATOLOGY, V69, P2672, DOI 10.1002/hep.30251
   Younossi Z, 2018, NAT REV GASTRO HEPAT, V15, P11, DOI 10.1038/nrgastro.2017.109
   Younossi ZM, 2019, LANCET, V394, P2184, DOI 10.1016/S0140-6736(19)33041-7
   Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431
   Yun HR, 2018, AM J KIDNEY DIS, V72, P400, DOI 10.1053/j.ajkd.2018.02.362
   Zhang X, 2017, TRANSL RES, V183, P14, DOI 10.1016/j.trsl.2016.12.004
   Zhang XR, 2022, HEPATOLOGY, V76, P469, DOI 10.1002/hep.32294
   Zhou X, 2016, OBES SURG, V26, P2590, DOI 10.1007/s11695-016-2144-x
NR 183
TC 4
Z9 4
U1 1
U2 7
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 2949-8147
EI 2949-8139
J9 ADV KIDNEY DIS HEAL
JI Adv. Kidney Dis. Heal.
PD JUL
PY 2023
VL 30
IS 4
BP 315
EP 335
DI 10.1053/j.akdh.2023.04.001
EA AUG 2023
PG 21
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA S2WD5
UT WOS:001069816500001
PM 37657879
DA 2025-06-11
ER

PT J
AU Sen, ZD
   Danyeli, LV
   Woelfer, M
   Lamers, F
   Wagner, G
   Sobanski, T
   Walter, M
AF Sen, Zumrut Duygu
   Danyeli, Lena Vera
   Woelfer, Marie
   Lamers, Femke
   Wagner, Gerd
   Sobanski, Thomas
   Walter, Martin
TI Linking atypical depression and insulin resistance-related disorders via
   low-grade chronic inflammation: Integrating the phenotypic, molecular
   and neuroanatomical dimensions
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Review
DE Inflammation; Major depressive disorder; Atypical depression; Type 2
   diabetes mellitus; Obesity; Metabolic syndrome; Insulin resistance;
   Stress; Anterior cingulate cortex
ID HIGH-FAT DIET; C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA; CEREBRAL
   GLUCOSE-METABOLISM; ANTERIOR CINGULATE CORTEX; MAJOR DEPRESSION;
   TNF-ALPHA; FUNCTIONAL CONNECTIVITY; CORTICAL THICKNESS; PREFRONTAL
   CORTEX
AB Insulin resistance (IR) and related disorders, such as T2DM, increase the risk of major depressive disorder (MDD) and vice versa. Current evidence indicates that psychological stress and overeating can induce chronic low-grade inflammation that can interfere with glutamate metabolism in MDD as well as insulin signaling, particularly in the atypical subtype. Here we first review the interactive role of inflammatory processes in the development of MDD, IR and related metabolic disorders. Next, we describe the role of the anterior cingulate cortex in the pathophysiology of MDD and IR-related disorders. Furthermore, we outline how specific clinical features of atypical depression, such as hyperphagia, are more associated with inflammation and IR-related disorders. Finally, we examine the regional specificity of the effects of inflammation on the brain that show an overlap with the functional and morphometric brain patterns activated in MDD and IR-related disorders.
C1 [Sen, Zumrut Duygu; Walter, Martin] Univ Tubingen, Dept Psychiat & Psychotherapy, Calwerstr 14, D-72076 Tubingen, Germany.
   [Sen, Zumrut Duygu; Danyeli, Lena Vera; Wagner, Gerd; Walter, Martin] Jena Univ Hosp, Dept Psychiat & Psychotherapy, Philosophenweg 3, D-07743 Jena, Germany.
   [Danyeli, Lena Vera; Woelfer, Marie; Walter, Martin] Clin Affect Neuroimaging Lab CANLAB, Leipziger Str 44,Bldg 65, D-39120 Magdeburg, Germany.
   [Danyeli, Lena Vera; Woelfer, Marie; Walter, Martin] Leibniz Inst Neurobiol, Brenneckestr 6, D-39118 Magdeburg, Germany.
   [Lamers, Femke] Vrije Univ, Amsterdam UMC, Dept Psychiat, Oldenaller 1, NL-1081 HJ Amsterdam, Netherlands.
   [Sobanski, Thomas] Thueringen Kliniken Georgius Agr GmbH, Dept Psychiat Psychotherapy & Psychosomat Med, Rainweg 68, D-07318 Saalfeld, Germany.
C3 Eberhard Karls University of Tubingen; Friedrich Schiller University of
   Jena; Leibniz Association; Leibniz Institut fur Neurobiologie (LIN);
   Vrije Universiteit Amsterdam; University of Amsterdam
RP Walter, M (corresponding author), Jena Univ Hosp, Dept Psychiat & Psychotherapy, Philosophenweg 3, D-07743 Jena, Germany.
EM martin.walter@med.uni-jena.de
RI Lamers, Femke/G-5161-2012; Wagner, Gerd/F-2990-2010
OI Woelfer, Marie/0000-0001-7128-4678
FU German Research Foundation (Deutsche Forschungsgemeinschaft, DFG)
   [SFB779-A06]; EU; Netherlands Organisation for Health Research and
   Development (ZonMw) [636310017]; Medical Faculty of the
   Otto-von-Guericke University Magdeburg; German Academic Exchange Service
   (DAAD)
FX This work was supported by the German Research Foundation (Deutsche
   Forschungsgemeinschaft, DFG, SFB779-A06 given to Prof. M. Walter) and
   through the EU-funded Horizon 2020 project "FAT4BBRAIN". Dr. Lamers
   currently receives funding from the Netherlands Organisation for Health
   Research and Development (ZonMw, project nr 636310017). M. Woelfer was
   supported by scholarship from the Medical Faculty of the
   Otto-von-Guericke University Magdeburg and received a scholarship from
   the German Academic Exchange Service (DAAD).
CR Ajilore O, 2015, INT J GERIATR PSYCH, V30, P393, DOI 10.1002/gps.4149
   Ajilore O, 2007, NEUROPSYCHOPHARMACOL, V32, P1224, DOI 10.1038/sj.npp.1301248
   Ajilore O, 2010, PSYCHIAT RES-NEUROIM, V184, P63, DOI 10.1016/j.pscychresns.2010.07.003
   Akiskal HS, 2005, J AFFECT DISORDERS, V84, P209, DOI 10.1016/j.jad.2004.05.004
   Alcocer-Gómez E, 2017, PHARMACOL RES, V121, P114, DOI 10.1016/j.phrs.2017.04.028
   Alexopoulos GS, 2019, TRANSL PSYCHIAT, V9, DOI 10.1038/s41398-019-0514-6
   Ali S, 2006, DIABETIC MED, V23, P1165, DOI 10.1111/j.1464-5491.2006.01943.x
   André C, 2014, BRAIN BEHAV IMMUN, V41, P10, DOI 10.1016/j.bbi.2014.03.012
   Angst J, 2006, EUR ARCH PSY CLIN N, V256, P44, DOI 10.1007/s00406-005-0600-z
   Angst J, 2002, J AFFECT DISORDERS, V72, P125, DOI 10.1016/S0165-0327(02)00169-6
   Anisman H, 1999, MOL PSYCHIATR, V4, P182, DOI 10.1038/sj.mp.4000436
   [Anonymous], 2019, Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2019, DOI [10.2337/dc09-1940., DOI 10.2337/dc09-1940]
   [Anonymous], 2019, CLASSIFICATION DIAGN
   [Anonymous], AVAILABLE PSYCHONEUR, V40, P48
   Araque A, 1999, TRENDS NEUROSCI, V22, P208, DOI 10.1016/S0166-2236(98)01349-6
   Arnold SE, 2014, NEUROBIOL DIS, V67, P79, DOI 10.1016/j.nbd.2014.03.011
   Arroyo C, 2004, DIABETES CARE, V27, P129, DOI 10.2337/diacare.27.1.129
   Aslani S, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.178
   Auer DP, 2000, BIOL PSYCHIAT, V47, P305, DOI 10.1016/S0006-3223(99)00159-6
   Bae JN, 2006, BIOL PSYCHIAT, V60, P1356, DOI 10.1016/j.biopsych.2006.03.052
   Baganz NL, 2013, ACS CHEM NEUROSCI, V4, P48, DOI 10.1021/cn300186b
   Baker Laura D, 2011, Arch Neurol, V68, P51, DOI 10.1001/archneurol.2010.225
   Ballmaier M, 2004, AM J PSYCHIAT, V161, P99, DOI 10.1176/appi.ajp.161.1.99
   Banasr M, 2010, MOL PSYCHIATR, V15, P501, DOI 10.1038/mp.2008.106
   Baufeld C, 2016, ACTA NEUROPATHOL, V132, P361, DOI 10.1007/s00401-016-1595-4
   Belanger M, 2011, J NEUROCHEM, V116, P564, DOI 10.1111/j.1471-4159.2010.07135.x
   Bénard M, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030217
   Benazzi Franco, 2003, Ann Clin Psychiatry, V15, P9, DOI 10.3109/10401230309085665
   Bennett FC, 2019, CLIN EXP IMMUNOL, V197, P294, DOI 10.1111/cei.13334
   Berman MG, 2011, SOC COGN AFFECT NEUR, V6, P548, DOI 10.1093/scan/nsq080
   Bezzi P, 2001, NAT NEUROSCI, V4, P702, DOI 10.1038/89490
   Bhattacharjee S, 2013, DIABETES-METAB RES, V29, P273, DOI 10.1002/dmrr.2393
   Blanco C, 2012, J CLIN PSYCHIAT, V73, P224, DOI 10.4088/JCP.10m06227
   Bluhm R, 2009, PSYCHIAT CLIN NEUROS, V63, P754, DOI 10.1111/j.1440-1819.2009.02030.x
   Blumenthal SR, 2014, JAMA PSYCHIAT, V71, P889, DOI 10.1001/jamapsychiatry.2014.414
   Bot M, 2020, BIOL PSYCHIAT, V87, P409, DOI 10.1016/j.biopsych.2019.08.016
   Bot M, 2015, BIOL PSYCHIAT, V77, DOI 10.1016/j.biopsych.2015.10.023
   Brandacher G, 2007, CURR DRUG METAB, V8, P289, DOI 10.2174/138920007780362590
   Brundin L, 2007, EUR NEUROPSYCHOPHARM, V17, P573, DOI 10.1016/j.euroneuro.2007.01.005
   Buckman LB, 2014, BRAIN BEHAV IMMUN, V35, P33, DOI 10.1016/j.bbi.2013.06.007
   Bush G, 2000, TRENDS COGN SCI, V4, P215, DOI 10.1016/S1364-6613(00)01483-2
   Cano V, 2014, NEUROREPORT, V25, P819, DOI 10.1097/WNR.0000000000000180
   Capuron L, 2004, BIOL PSYCHIAT, V56, P819, DOI 10.1016/j.biopsych.2004.02.009
   Capuron L, 2002, NEUROPSYCHOPHARMACOL, V26, P643, DOI 10.1016/S0893-133X(01)00407-9
   Capuron L, 2017, NEUROPSYCHOPHARMACOL, V42, P115, DOI 10.1038/npp.2016.123
   Capuron L, 2011, BIOL PSYCHIAT, V70, P175, DOI 10.1016/j.biopsych.2010.12.006
   Carpenter LL, 2010, NEUROPSYCHOPHARMACOL, V35, P2617, DOI 10.1038/npp.2010.159
   Carrard A, 2018, MOL PSYCHIATR, V23, P392, DOI 10.1038/mp.2016.179
   Casamenti F, 1999, NEUROSCIENCE, V91, P831, DOI 10.1016/S0306-4522(98)00680-0
   Chan KL, 2019, PHYSIOLOGY, V34, P123, DOI 10.1152/physiol.00047.2018
   Chatton JY, 2000, EUR J NEUROSCI, V12, P3843, DOI 10.1046/j.1460-9568.2000.00269.x
   Chiba T, 2001, BRAIN RES, V888, P83, DOI 10.1016/S0006-8993(00)03013-4
   Choudary PV, 2005, P NATL ACAD SCI USA, V102, P15653, DOI 10.1073/pnas.0507901102
   Chuang JC, 2010, J LIPID RES, V51, P1344, DOI 10.1194/jlr.M002196
   Coope A, 2016, EUR J ENDOCRINOL, V174, pR175, DOI 10.1530/EJE-15-1065
   Cui Y, 2016, AM J NEURORADIOL, V37, P2115, DOI 10.3174/ajnr.A4858
   Dahl J, 2014, PSYCHONEUROENDOCRINO, V45, P77, DOI 10.1016/j.psyneuen.2014.03.019
   Dallman MF, 2003, P NATL ACAD SCI USA, V100, P11696, DOI 10.1073/pnas.1934666100
   Daly M, 2013, OBESITY, V21, P248, DOI 10.1002/oby.20051
   Danbolt NC, 2001, PROG NEUROBIOL, V65, P1, DOI 10.1016/S0301-0082(00)00067-8
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   Dantzer R, 2018, PHYSIOL REV, V98, P477, DOI 10.1152/physrev.00039.2016
   Davies KA, 2021, MOL PSYCHIATR, V26, P5150, DOI 10.1038/s41380-020-0790-9
   de Kluiver H, 2019, TRANSL PSYCHIAT, V9, DOI 10.1038/s41398-019-0528-0
   De Souza CT, 2005, ENDOCRINOLOGY, V146, P4192, DOI 10.1210/en.2004-1520
   Desmidt T, 2011, PSYCHIAT RES-NEUROIM, V193, P63, DOI 10.1016/j.pscychresns.2011.01.002
   Ding Y., 2019, OBESITY
   DiNuzzo M, 2012, NEUROCHEM RES, V37, P2432, DOI 10.1007/s11064-012-0802-5
   DiSabato DJ, 2016, J NEUROCHEM, V139, P136, DOI 10.1111/jnc.13607
   Dortland AKBV, 2010, ACTA PSYCHIAT SCAND, V122, P30, DOI 10.1111/j.1600-0447.2010.01565.x
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Duffy CM, 2019, NEUROBIOL LEARN MEM, V157, P41, DOI 10.1016/j.nlm.2018.11.008
   Duffy CM, 2015, NEUROSCI LETT, V606, P140, DOI 10.1016/j.neulet.2015.08.033
   Duman RS, 2014, DEPRESS ANXIETY, V31, P291, DOI 10.1002/da.22227
   Dutheil S, 2016, NEUROPSYCHOPHARMACOL, V41, P1874, DOI 10.1038/npp.2015.357
   Emery CF, 2007, OBES SURG, V17, P759, DOI 10.1007/s11695-007-9140-0
   Di Rosso ME, 2016, PHARMACOL RES, V109, P101, DOI 10.1016/j.phrs.2015.11.021
   Etkin A, 2011, TRENDS COGN SCI, V15, P85, DOI 10.1016/j.tics.2010.11.004
   Euesden J, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0173015
   Favennec M, 2015, OBESITY, V23, P2066, DOI 10.1002/oby.21199
   Fellin T, 2004, NEURON, V43, P729, DOI 10.1016/j.neuron.2004.08.011
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Fremeau RT, 2004, SCIENCE, V304, P1815, DOI 10.1126/science.1097468
   Fritz BM, 2018, NEUROSCIENCE, V372, P1, DOI 10.1016/j.neuroscience.2017.12.036
   Fuchs M, 2012, J HEPATOL, V56, P291, DOI 10.1016/j.jhep.2011.05.019
   Fugger G, 2019, PROG NEURO-PSYCHOPH, V94, DOI 10.1016/j.pnpbp.2019.109638
   García-Díaz DF, 2007, J PHYSIOL BIOCHEM, V63, P337, DOI 10.1007/BF03165765
   Gavillet M, 2008, GLIA, V56, P975, DOI 10.1002/glia.20671
   Gecici O, 2005, PSYCHIAT CLIN NEUROS, V59, P736, DOI 10.1111/j.1440-1819.2005.01445.x
   Geissler A., 2003, EXP CLIN ENDOCR DIAB
   Ghashghaei H, 2007, NEUROIMAGE, V34, P905, DOI 10.1016/j.neuroimage.2006.09.046
   Gibbs ME, 2007, J NEUROSCI RES, V85, P3326, DOI 10.1002/jnr.21307
   Gili M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048200
   Glaus J, 2014, J PSYCHIATR RES, V58, P36, DOI 10.1016/j.jpsychires.2014.07.012
   Gold SM, 2007, DIABETOLOGIA, V50, P711, DOI 10.1007/s00125-007-0602-7
   González HM, 2013, INT PSYCHOGERIATR, V25, P833, DOI 10.1017/S1041610212002062
   Graf H, 2013, INT J NEUROPSYCHOPH, V16, P1219, DOI 10.1017/S1461145712001368
   Gramaglia C, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00621
   Grillo CA, 2011, BEHAV BRAIN RES, V222, P230, DOI 10.1016/j.bbr.2011.03.052
   Grundy A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0099780
   Guillemin GJ, 2005, GLIA, V49, P15, DOI 10.1002/glia.20090
   Guillemin GJ, 2001, J NEUROCHEM, V78, P842, DOI 10.1046/j.1471-4159.2001.00498.x
   Haapakoski R, 2015, BRAIN BEHAV IMMUN, V49, P206, DOI 10.1016/j.bbi.2015.06.001
   Haber SN, 2010, NEUROPSYCHOPHARMACOL, V35, P4, DOI 10.1038/npp.2009.129
   Han TS, 2002, DIABETES CARE, V25, P2016, DOI 10.2337/diacare.25.11.2016
   Hannestad J, 2011, NEUROPSYCHOPHARMACOL, V36, P2452, DOI 10.1038/npp.2011.132
   Hao S, 2016, BRAIN BEHAV IMMUN, V51, P230, DOI 10.1016/j.bbi.2015.08.023
   Hara J, 2005, NEUROSCI LETT, V380, P239, DOI 10.1016/j.neulet.2005.01.046
   Haroon E, 2017, NEUROPSYCHOPHARMACOL, V42, P193, DOI 10.1038/npp.2016.199
   Haroon E, 2014, NEUROPSYCHOPHARMACOL, V39, P1777, DOI 10.1038/npp.2014.25
   Haroon E, 2009, PSYCHIAT RES-NEUROIM, V171, P10, DOI 10.1016/j.pscychresns.2008.03.006
   Harrison NA, 2009, BIOL PSYCHIAT, V66, P407, DOI 10.1016/j.biopsych.2009.03.015
   Hasin DS, 2018, JAMA PSYCHIAT, V75, P336, DOI 10.1001/jamapsychiatry.2017.4602
   Hassenstab JJ, 2012, PSYCHIAT RES-NEUROIM, V202, P77, DOI 10.1016/j.pscychresns.2011.09.008
   Henkel V, 2006, PSYCHIAT RES, V141, P89, DOI 10.1016/j.psychres.2005.07.012
   Hickman RJ, 2014, J BEHAV MED, V37, P621, DOI 10.1007/s10865-013-9510-0
   Himmerich H, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00030
   Hong GB, 2020, DIABET METAB SYND OB, V13, P581, DOI 10.2147/DMSO.S241774
   HORWATH E, 1992, J AFFECT DISORDERS, V26, P117, DOI 10.1016/0165-0327(92)90043-6
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Howard JK, 2004, NAT MED, V10, P734, DOI 10.1038/nm1072
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Hu SX, 2000, NEUROIMMUNOMODULAT, V7, P153, DOI 10.1159/000026433
   Hu YZ, 2015, JAMA PSYCHIAT, V72, P584, DOI 10.1001/jamapsychiatry.2015.1
   Hyvärinen T, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-53414-9
   Ida T, 2008, NEUROSCI LETT, V432, P232, DOI 10.1016/j.neulet.2007.12.047
   Iwata M, 2013, BRAIN BEHAV IMMUN, V31, P105, DOI 10.1016/j.bbi.2012.12.008
   Järnum H, 2011, ACTA PSYCHIAT SCAND, V124, P435, DOI 10.1111/j.1600-0447.2011.01766.x
   Jiang K., 2016, ATYPICAL FEATURESAND
   Kampe J, 2009, EUR J NEUROSCI, V30, P415, DOI 10.1111/j.1460-9568.2009.06818.x
   Kan C, 2013, DIABETES CARE, V36, P480, DOI 10.2337/dc12-1442
   Kang EB, 2016, J NEUROENDOCRINOL, V28, DOI 10.1111/jne.12385
   Karlovic D, 2012, PSYCHIAT RES, V198, P74, DOI 10.1016/j.psychres.2011.12.007
   Kennedy A, 2009, J NUTR, V139, P1, DOI 10.3945/jn.108.098269
   KEYMEULEN B, 1995, NUCL MED COMMUN, V16, P10, DOI 10.1097/00006231-199501000-00005
   Kilic K, 2018, ANN NEUROL, V83, P61, DOI 10.1002/ana.25122
   Kitagawa Y, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-44006-8
   Kleinridders A, 2015, P NATL ACAD SCI USA, V112, P3463, DOI 10.1073/pnas.1500877112
   Knol MJ, 2006, DIABETOLOGIA, V49, P837, DOI 10.1007/s00125-006-0159-x
   Kobrosly RW, 2010, ANN EPIDEMIOL, V20, P852, DOI 10.1016/j.annepidem.2010.08.002
   Korn T, 2005, FASEB J, V19, P1878, DOI 10.1096/fj.05-3748fje
   Kraynak TE, 2018, NEUROSCI BIOBEHAV R, V94, P76, DOI 10.1016/j.neubiorev.2018.07.013
   Kumar A, 2016, MOL PSYCHIATR, V21, P531, DOI 10.1038/mp.2015.89
   Kumar A, 2012, P INT SOC MAG RESON, V20
   Kumar A, 2008, J MAGN RESON IMAGING, V27, P14, DOI 10.1002/jmri.21224
   Kumar A, 2009, ARCH GEN PSYCHIAT, V66, P324, DOI 10.1001/archgenpsychiatry.2008.548
   Kumar J, 2013, APPETITE, V64, P81, DOI 10.1016/j.appet.2012.12.023
   Kvamme E, 2000, NEUROCHEM RES, V25, P1407, DOI 10.1023/A:1007668801570
   Lainampetch J, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/9051929
   Lamers F, 2018, PSYCHOL MED, V48, P1102, DOI 10.1017/S0033291717002483
   Lamers F, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.115
   Langer J, 2009, J PHYSIOL-LONDON, V587, P5859, DOI 10.1113/jphysiol.2009.182279
   Lasserre AM, 2014, JAMA PSYCHIAT, V71, P880, DOI 10.1001/jamapsychiatry.2014.411
   Lee JC, 2018, BBA-MOL CELL BIOL L, V1863, P980, DOI 10.1016/j.bbalip.2018.05.007
   Levitan RD, 2012, J CLIN PSYCHIAT, V73, P1119, DOI 10.4088/JCP.11m07394
   Li CT, 2019, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00767
   Li M, 2014, J AFFECT DISORDERS, V169, P91, DOI 10.1016/j.jad.2014.08.001
   Liddelow SA, 2017, NATURE, V541, P481, DOI 10.1038/nature21029
   Liu DH, 2018, FRONT AGING NEUROSCI, V10, DOI 10.3389/fnagi.2018.00055
   Liu XF, 2019, FRONT NEUROSCI-SWITZ, V13, DOI 10.3389/fnins.2019.01217
   Lu J, 2017, EBIOMEDICINE, V18, P311, DOI 10.1016/j.ebiom.2017.03.043
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Lutter M, 2008, J NEUROSCI, V28, P3071, DOI 10.1523/JNEUROSCI.5584-07.2008
   Magistretti PJ, 2015, NEURON, V86, P883, DOI 10.1016/j.neuron.2015.03.035
   Makimattila S., 2004, J CEREBR BLOOD F MET
   Malhi GS, 2018, LANCET, V392, P2299, DOI 10.1016/S0140-6736(18)31948-2
   Mandolesi G, 2013, J NEUROSCI, V33, P12105, DOI 10.1523/JNEUROSCI.5369-12.2013
   Mangge H, 2014, OBESITY, V22, P195, DOI 10.1002/oby.20491
   Mansouri FA, 2009, NAT REV NEUROSCI, V10, P141, DOI 10.1038/nrn2538
   Martín-Hernández D, 2019, MOL NEUROBIOL, V56, P490, DOI 10.1007/s12035-018-1096-7
   MARTINEZHERNANDEZ A, 1977, SCIENCE, V195, P1356, DOI 10.1126/science.14400
   Matza LS, 2003, ARCH GEN PSYCHIAT, V60, P817, DOI 10.1001/archpsyc.60.8.817
   Mayberg HS, 1997, J NEUROPSYCH CLIN N, V9, P471
   McGillicuddy FC, 2011, DIABETES, V60, P1688, DOI 10.2337/db10-1278
   Mesci P, 2015, BRAIN, V138, P53, DOI 10.1093/brain/awu312
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Milaneschi Y, 2016, MOL PSYCHIATR, V21, P516, DOI 10.1038/mp.2015.86
   Milaneschi Y, 2020, BIOL PSYCHIAT, V88, P369, DOI 10.1016/j.biopsych.2020.01.014
   Milaneschi Y, 2017, JAMA PSYCHIAT, V74, P1214, DOI 10.1001/jamapsychiatry.2017.3016
   Milanski M, 2009, J NEUROSCI, V29, P359, DOI 10.1523/JNEUROSCI.2760-08.2009
   Miller AH, 2017, NEUROPSYCHOPHARMACOL, V42, P334, DOI 10.1038/npp.2016.167
   Mirza S, 2012, CYTOKINE, V57, P136, DOI 10.1016/j.cyto.2011.09.029
   Mommersteeg PMC, 2013, DIABETIC MED, V30, pE208, DOI 10.1111/dme.12193
   Moran C, 2013, DIABETES CARE, V36, P4036, DOI 10.2337/dc13-0143
   Morinaga H, 2015, DIABETES, V64, P1120, DOI 10.2337/db14-1238
   Nigatu YT, 2015, BMC PUBLIC HEALTH, V15, DOI 10.1186/s12889-015-1682-9
   Nobunaga M, 2014, NEUROCHEM INT, V78, P61, DOI 10.1016/j.neuint.2014.09.002
   Novick JS, 2005, J CLIN PSYCHIAT, V66, P1002, DOI 10.4088/JCP.v66n0807
   O'Connor JC, 2009, J IMMUNOL, V182, P3202, DOI 10.4049/jimmunol.0802722
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Öngür D, 2003, J COMP NEUROL, V460, P425, DOI 10.1002/cne.10609
   Osuch EA, 2000, BIOL PSYCHIAT, V48, P1020, DOI 10.1016/S0006-3223(00)00920-3
   Pace TWW, 2006, AM J PSYCHIAT, V163, P1630, DOI 10.1176/appi.ajp.163.9.1630
   Palomero-Gallagher N, 2008, J COMP NEUROL, V508, P906, DOI 10.1002/cne.21684
   Palomero-Gallagher N, 2009, HUM BRAIN MAPP, V30, P2336, DOI 10.1002/hbm.20667
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pan Y, 2013, PSYCHONEUROENDOCRINO, V38, P122, DOI 10.1016/j.psyneuen.2012.05.007
   Park HY, 2012, PROG NEURO-PSYCHOPH, V36, P318, DOI 10.1016/j.pnpbp.2011.11.010
   Park HS, 2017, PSYCHIAT RES, V250, P71, DOI 10.1016/j.psychres.2017.01.012
   Parker G, 2002, AM J PSYCHIAT, V159, P1470, DOI 10.1176/appi.ajp.159.9.1470
   Patten SB, 2011, CAN J PSYCHIAT, V56, P658, DOI 10.1177/070674371105601104
   Paxinos G, 2012, HUMAN NERVOUS SYSTEM, V3rd, P943
   PELLERIN L, 1994, P NATL ACAD SCI USA, V91, P10625, DOI 10.1073/pnas.91.22.10625
   Pellerin L, 2007, GLIA, V55, P1251, DOI 10.1002/glia.20528
   Peña S, 2005, INT IMMUNOPHARMACOL, V5, P1069, DOI 10.1016/j.intimp.2005.02.005
   Penninx BWJH, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-129
   Persson M, 2007, GLIA, V55, P1449, DOI 10.1002/glia.20560
   Perugi G, 2013, ACTA PSYCHIAT SCAND, V128, P376, DOI 10.1111/acps.12083
   Petersen MC, 2018, PHYSIOL REV, V98, P2133, DOI 10.1152/physrev.00063.2017
   Phillips OR, 2018, PEDIATR DIABETES, V19, P892, DOI 10.1111/pedi.12672
   Pizzagalli DA, 2016, DEPRESS ANXIETY, V33, P891, DOI 10.1002/da.22550
   Pohl J, 2009, ENDOCRINOLOGY, V150, P4901, DOI 10.1210/en.2009-0526
   Pomytkin I, 2018, CNS NEUROSCI THER, V24, P763, DOI 10.1111/cns.12866
   Porras OH, 2008, GLIA, V56, P59, DOI 10.1002/glia.20589
   Posternak MA, 2002, COMPR PSYCHIAT, V43, P253, DOI 10.1053/comp.2002.33498
   Raffield LM, 2016, J DIABETES COMPLICAT, V30, P143, DOI 10.1016/j.jdiacomp.2015.09.010
   Rainero I, 2011, J AFFECT DISORDERS, V130, P487, DOI 10.1016/j.jad.2010.10.033
   Raison CL, 2017, NEUROPSYCHOPHARMACOL, V42, P5, DOI 10.1038/npp.2016.194
   Raji CA, 2010, HUM BRAIN MAPP, V31, P353, DOI 10.1002/hbm.20870
   Rethorst CD, 2013, PSYCHOL MED, V43, P699, DOI 10.1017/S0033291712001675
   Rethorst CD, 2016, J AFFECT DISORDERS, V200, P156, DOI 10.1016/j.jad.2016.01.052
   Reyna SM, 2008, DIABETES, V57, P2595, DOI 10.2337/db08-0038
   Roden M, 2000, DIABETES, V49, P701, DOI 10.2337/diabetes.49.5.701
   Rodgers S, 2016, J AFFECT DISORDERS, V190, P807, DOI 10.1016/j.jad.2015.10.067
   Roy T, 2012, J AFFECT DISORDERS, V142, pS8, DOI 10.1016/S0165-0327(12)70004-6
   Rudolf S, 2014, PSYCHIAT RES, V217, P34, DOI 10.1016/j.psychres.2014.02.016
   Rusakov DA, 1998, J NEUROSCI, V18, P3158
   Ryan JP, 2012, PSYCHOSOM MED, V74, P476, DOI 10.1097/PSY.0b013e31824d0865
   Santos AC, 2005, INT J OBESITY, V29, P1452, DOI 10.1038/sj.ijo.0803035
   Schaeffler A, 2009, IMMUNOLOGY, V126, P233, DOI 10.1111/j.1365-2567.2008.02892.x
   Schafer DP, 2013, GLIA, V61, P24, DOI 10.1002/glia.22389
   Schousboe A, 2010, NEUROTOX RES, V18, P94, DOI 10.1007/s12640-010-9171-5
   SCHWARCZ R, 1983, SCIENCE, V219, P316, DOI 10.1126/science.6849138
   Schwarcz R, 2012, NAT REV NEUROSCI, V13, P465, DOI 10.1038/nrn3257
   Seminowicz DA, 2004, PAIN, V112, P48, DOI 10.1016/j.pain.2004.07.027
   SHANK RP, 1985, BRAIN RES, V329, P364, DOI 10.1016/0006-8993(85)90552-9
   Sharma AN, 2010, PHYSIOL BEHAV, V101, P381, DOI 10.1016/j.physbeh.2010.07.002
   Sickmann HM, 2009, J NEUROCHEM, V109, P80, DOI 10.1111/j.1471-4159.2009.05915.x
   Sickmann HM, 2012, NEUROCHEM INT, V60, P267, DOI 10.1016/j.neuint.2011.12.019
   Sickmann HM, 2005, NEUROCHEM RES, V30, P1295, DOI 10.1007/s11064-005-8801-4
   Simmons WK, 2020, MOL PSYCHIATR, V25, P1457, DOI 10.1038/s41380-018-0093-6
   Singh MK, 2019, HORM BEHAV, V108, P73, DOI 10.1016/j.yhbeh.2018.03.009
   Sitcheran R, 2005, EMBO J, V24, P510, DOI 10.1038/sj.emboj.7600555
   Spinelli M, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-02221-9
   Steiner J, 2008, J PSYCHIATR RES, V42, P151, DOI 10.1016/j.jpsychires.2006.10.013
   Steiner J, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-94
   Stewart JW, 2010, INT J NEUROPSYCHOPH, V13, P15, DOI 10.1017/S1461145709000182
   STONE TW, 1981, EUR J PHARMACOL, V72, P411, DOI 10.1016/0014-2999(81)90587-2
   Strawbridge R, 2015, EUR NEUROPSYCHOPHARM, V25, P1532, DOI 10.1016/j.euroneuro.2015.06.007
   Stunkard AJ, 2003, BIOL PSYCHIAT, V54, P330, DOI 10.1016/S0006-3223(03)00608-5
   Su WJ, 2017, J NEUROINFLAMM, V14, DOI 10.1186/s12974-017-0985-4
   Takahashi JL, 2003, ANN NEUROL, V53, P588, DOI 10.1002/ana.10519
   Takaki J, HYPOTHESIS INCREASED
   Takeuchi H, 2006, J BIOL CHEM, V281, P21362, DOI 10.1074/jbc.M600504200
   Thaler JP, 2012, J CLIN INVEST, V122, P153, DOI 10.1172/JCI59660
   Thaler JP, 2010, FRONT NEUROENDOCRIN, V31, P79, DOI 10.1016/j.yfrne.2009.10.002
   Toups MSP, 2011, J PSYCHIATR RES, V45, P1301, DOI 10.1016/j.jpsychires.2011.05.002
   Tsai SF, 2018, BRAIN RES, V1700, P66, DOI 10.1016/j.brainres.2018.07.017
   Tsai SF, 2018, NEUROSCI LETT, V662, P142, DOI 10.1016/j.neulet.2017.10.024
   Tsuneki H, 2013, NEUROPEPTIDES, V47, P213, DOI 10.1016/j.npep.2013.02.002
   Tzingounis AV, 2007, NAT REV NEUROSCI, V8, P935, DOI 10.1038/nrn2274
   Uysal KT, 1997, NATURE, V389, P610, DOI 10.1038/39335
   Vaidya CJ, 2008, DEV DISABIL RES REV, V14, P261, DOI 10.1002/ddrr.40
   Valdearcos M, 2017, CELL METAB, V26, P185, DOI 10.1016/j.cmet.2017.05.015
   Valdearcos M, 2014, CELL REP, V9, P2124, DOI 10.1016/j.celrep.2014.11.018
   van Harten B., 2006, DIABETES CARE
   Van Landeghem FKH, 2001, GLIA, V35, P167, DOI 10.1002/glia.1082
   Vancassel S, 2018, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00499
   Vanhala M, 2009, ACTA PSYCHIAT SCAND, V119, P137, DOI 10.1111/j.1600-0447.2008.01283.x
   Vogelzangs N, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.8
   Vogt BA, 2005, NAT REV NEUROSCI, V6, P533, DOI 10.1038/nrn1704
   VOGT BA, 1995, J COMP NEUROL, V359, P490, DOI 10.1002/cne.903590310
   Vogt BA, 2005, J COMP NEUROL, V485, P218, DOI 10.1002/cne.20512
   Vogt BA, 2003, EUR J NEUROSCI, V18, P3134, DOI 10.1111/j.1460-9568.2003.03034.x
   Voutsinos-Porche B, 2003, NEURON, V37, P275, DOI 10.1016/S0896-6273(02)01170-4
   Walker AK, 2013, NEUROPSYCHOPHARMACOL, V38, P1609, DOI 10.1038/npp.2013.71
   Walter M, 2009, ARCH GEN PSYCHIAT, V66, P478, DOI 10.1001/archgenpsychiatry.2009.39
   Wang YX, 2010, BRAIN BEHAV IMMUN, V24, P201, DOI 10.1016/j.bbi.2009.06.152
   Watari K, 2008, J CLIN EXP NEUROPSYC, V30, P389, DOI 10.1080/13803390701440486
   Wegener G, 2019, INFLAMMATION INSULIN
   Wen HT, 2011, NAT IMMUNOL, V12, P408, DOI 10.1038/ni.2022
   Weng HR, 2007, NEUROSCIENCE, V149, P898, DOI 10.1016/j.neuroscience.2007.07.063
   Whale R, 2019, BRAIN BEHAV IMMUN, V80, P519, DOI 10.1016/j.bbi.2019.04.035
   Wijngaarden MA, 2015, BEHAV BRAIN RES, V287, P127, DOI 10.1016/j.bbr.2015.03.016
   Woelfer M, 2019, NEUROSCIENCE, V403, P93, DOI 10.1016/j.neuroscience.2018.03.034
   Wu HZ, 2007, CIRCULATION, V115, P1029, DOI 10.1161/CIRCULATIONAHA.106.638379
   Xia MR, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0068910
   Xia WQ, 2018, J AFFECT DISORDERS, V228, P207, DOI 10.1016/j.jad.2017.12.012
   Xu QY, 2011, OBES RES CLIN PRACT, V5, pE267, DOI 10.1016/j.orcp.2011.04.007
   Yang C, 2013, MOL MED REP, V8, P887, DOI 10.3892/mmr.2013.1600
   Yapici-Eser H, 2018, EXP NEUROL, V307, P45, DOI 10.1016/j.expneurol.2018.05.024
   Yi CX, 2012, PHYSIOL BEHAV, V106, P485, DOI 10.1016/j.physbeh.2012.03.021
   Yoon HK, 2012, NORD J PSYCHIAT, V66, P183, DOI 10.3109/08039488.2011.611894
   Yoon JM, 2013, KOREAN J FAM MED, V34, P228, DOI 10.4082/kjfm.2013.34.4.228
   YU ACH, 1983, J NEUROCHEM, V41, P1484, DOI 10.1111/j.1471-4159.1983.tb00849.x
   Zhang AF, 2013, NEUROPSYCHOPHARMACOL, V38, P1451, DOI 10.1038/npp.2013.41
   Zhang B, 2015, NEUROSCI LETT, V584, P156, DOI 10.1016/j.neulet.2014.10.020
   Zhang XQ, 2008, CELL, V135, P61, DOI 10.1016/j.cell.2008.07.043
   Zhao YN, 2017, SCI REP-UK, V7, DOI 10.1038/srep43192
   Zheng H, 2017, BBA-MOL BASIS DIS, V1863, P266, DOI 10.1016/j.bbadis.2016.11.003
   Zheng YQ, 2016, MOL BRAIN, V9, DOI 10.1186/s13041-016-0223-5
   ZIEGLER D, 1994, DIABETIC MED, V11, P205, DOI 10.1111/j.1464-5491.1994.tb02021.x
NR 302
TC 32
Z9 35
U1 3
U2 20
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD MAR
PY 2021
VL 93
BP 335
EP 352
DI 10.1016/j.bbi.2020.12.020
EA MAR 2021
PG 18
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA RB3SE
UT WOS:000632033800007
PM 33359233
OA Green Published
DA 2025-06-11
ER

PT J
AU Lin, ZQ
   Lawrence, WR
   Huang, YH
   Lin, QX
   Gao, YH
AF Lin, Ziqiang
   Lawrence, Wayne R.
   Huang, Yanhong
   Lin, Qiaoxuan
   Gao, Yanhui
TI Classifying depression using blood biomarkers: A large population study
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Depression; Machine learning; Random forest; Obesity; Diabetes;
   Metabolic syndrome
ID DISSEMINATED INTRAVASCULAR COAGULATION; CELL DISTRIBUTION WIDTH; FATTY
   LIVER-DISEASE; METABOLIC SYNDROME; INCOME INEQUALITY; MAJOR DEPRESSION;
   MENTAL-HEALTH; ASSOCIATION; BILIRUBIN; BASOPHILS
AB Background: Depression is a common mood disorder characterized by persistent low mood or lack of interest in activities. People with other chronic medical conditions such as obesity and diabetes are at greater risk of depression. Diagnosing depression can be a challenge for primary care providers and others who lack specialized training for these disorders and have insufficient time for in-depth clinical evaluation. We aimed to create a more objective low-cost diagnostic tool based on patients' characteristics and blood biomarkers. Methods: Blood biomarker results were obtained from the National Health and Nutrition Examination Survey (NHANES, 2007-2016). A prediction model utilizing random forest (RF) in NHANES (2007-2014) to identify depression was derived and validated internally using out-of-bag technique. Afterwards, the model was validated externally using a validation dataset (NHANES, 2015-2016). We performed four subgroup comparisons (full dataset, overweight and obesity dataset (BMI >= 25), diabetes dataset, and metabolic syndrome dataset) then selected features using backward feature selection from RF. Results: Family income, Gamma-glutamyl transferase (GGT), glucose, Triglyceride, red cell distribution width (RDW), creatinine, Basophils count or percent, Eosinophils count or percent, and Bilirubin were the most important features from four models. In the training set, AUC from full, overweight and obesity, diabetes, and metabolic syndrome datasets were 0.83, 0.80, 0.82, and 0.82, respectively. In the validation set, AUC were 0.69, 0.63, 0.66, and 0.64, respectively. Conclusion: Results of routine blood laboratory tests had good predictive value for distinguishing depression cases from control groups not only in the general population, but also individuals with metabolism-related chronic diseases.
C1 [Lin, Ziqiang; Gao, Yanhui] Jinan Univ, Sch Basic Med & Publ Hlth, Dept Prevent Med, Guangzhou 510632, Peoples R China.
   [Lin, Ziqiang] New York Univ Sch Med, Dept Psychiat, 1 Pk Ave, New York, NY 10016 USA.
   [Lin, Ziqiang] SUNY Albany, Dept Math & Stat, Coll Arts & Sci, 1400 Washington Ave, Albany, NY 12222 USA.
   [Lawrence, Wayne R.] SUNY Albany, Sch Publ Hlth, Dept Epidemiol & Biostat, 1 Univ Pl, Rensselaer, NY 12144 USA.
   [Huang, Yanhong] Guangdong Pharmaceut Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Guangzhou 510310, Peoples R China.
   [Lin, Qiaoxuan] Guangzhou Hlth Technol Identificat & Human Resour, Dept Stat, Guangzhou 510000, Guangdong, Peoples R China.
C3 Jinan University; New York University; State University of New York
   (SUNY) System; University at Albany, SUNY; State University of New York
   (SUNY) System; University at Albany, SUNY; Guangdong Pharmaceutical
   University
RP Gao, YH (corresponding author), Jinan Univ, Sch Basic Med & Publ Hlth, Dept Prevent Med, Guangzhou 510632, Peoples R China.
EM gao_yanhui@163.com
RI Lin, Qiaoxuan/AAC-1202-2022; Lawrence, Wayne/N-3626-2016
OI Lin, Ziqiang/0000-0003-1990-6788
FU National Social Science Foundation, China (2019 key project of education
   sciences) [ALA190015]
FX This Study was supported by supported by National Social Science
   Foundation, China (2019 key project of education sciences, grant number
   ALA190015) .
CR Ahern J, 2006, J EPIDEMIOL COMMUN H, V60, P766, DOI 10.1136/jech.2006.042069
   Almeida OP, 2007, AM J GERIAT PSYCHIAT, V15, P506, DOI 10.1097/01.JGP.0000246869.49892.77
   Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   Avenevoli S, 2015, J AM ACAD CHILD PSY, V54, P37, DOI 10.1016/j.jaac.2014.10.010
   Baek JH, 2016, PSYCHIAT INVEST, V13, P321, DOI 10.4306/pi.2016.13.3.321
   Barrett BW, 2021, SOC PSYCH PSYCH EPID, V56, P259, DOI 10.1007/s00127-020-01940-7
   Bartlett CL, 2019, LECT NOTES ARTIF INT, V11526, P311, DOI 10.1007/978-3-030-21642-9_40
   Breiman L, 2001, MACH LEARN, V45, P5, DOI 10.1023/A:1010933404324
   Burns JK, 2017, HEALTH PLACE, V45, P10, DOI 10.1016/j.healthplace.2017.02.005
   Burtis C.A., 1994, TIETZ TXB CLIN CHEM
   Castro MA, 1996, AM J OBSTET GYNECOL, V174, P211, DOI 10.1016/S0002-9378(96)70396-4
   Cepeda MS, 2020, J CLIN LIPIDOL, V14, P515, DOI 10.1016/j.jacl.2020.06.001
   Chapuy L, 2014, J ALLERGY CLIN IMMUN, V134, P978, DOI 10.1016/j.jaci.2014.05.025
   Chawla NV, 2002, J ARTIF INTELL RES, V16, P321, DOI 10.1613/jair.953
   de Groot M, 2001, PSYCHOSOM MED, V63, P619, DOI 10.1097/00006842-200107000-00015
   Demircan F, 2016, NEUROL THER, V5, P27, DOI 10.1007/s40120-015-0039-8
   Dere E, 2010, BEHAV BRAIN RES, V215, P209, DOI 10.1016/j.bbr.2009.12.045
   Drevets WC, 2002, EUR NEUROPSYCHOPHARM, V12, P527, DOI 10.1016/S0924-977X(02)00102-5
   Drevets WC, 2002, PHARMACOL BIOCHEM BE, V71, P431, DOI 10.1016/S0091-3057(01)00687-6
   Fujii H, 2020, BMC GASTROENTEROL, V20, DOI 10.1186/s12876-020-01369-x
   Gheshlagh RG, 2016, IRAN RED CRESCENT ME, V18, DOI 10.5812/ircmj.26523
   Gulliver A, 2010, BMC PSYCHIATRY, V10, DOI 10.1186/1471-244X-10-113
   Gundogmus I, 2019, PSYCHIAT CLIN PSYCH, V29, P520, DOI 10.1080/24750573.2018.1468616
   Hales Craig M, 2020, NCHS Data Brief, P1, DOI 10.21608/seaf.2020.162168
   Hasin DS, 2018, JAMA PSYCHIAT, V75, P336, DOI 10.1001/jamapsychiatry.2017.4602
   Holt RIG, 2014, CURR DIABETES REP, V14, DOI 10.1007/s11892-014-0491-3
   HOYLE CF, 1989, J CLIN PATHOL, V42, P785, DOI 10.1136/jcp.42.8.785
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Huang XQ, 2017, FRONT MOL NEUROSCI, V10, DOI 10.3389/fnmol.2017.00134
   Irwin JR, 2003, J MARKETING RES, V40, P366, DOI 10.1509/jmkr.40.3.366.19237
   Kahn L.S., 2011, DEPRESS RES TREAT, V2011
   Kim D, 2019, ALIMENT PHARM THER, V50, P590, DOI 10.1111/apt.15395
   Kious BM, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9090406
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Lee CT, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000003110
   LIEBMAN HA, 1983, ANN INTERN MED, V98, P330, DOI 10.7326/0003-4819-98-3-330
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Lyons TJ, 2012, TRANSL RES, V159, P303, DOI 10.1016/j.trsl.2012.01.009
   Maes M, 1996, J AFFECT DISORDERS, V40, P23, DOI 10.1016/0165-0327(96)00038-9
   De la Roca-Chiapas JM, 2013, REV INVEST CLIN, V65, P209
   May H.T., 2013, CIRCULATION, V128, pS314
   Menze BH, 2009, BMC BIOINFORMATICS, V10, DOI 10.1186/1471-2105-10-213
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Miyaoka T, 2005, EUR NEUROPSYCHOPHARM, V15, P249, DOI 10.1016/j.euroneuro.2004.11.002
   Moazzami K, 2019, HEALTH PSYCHOL, V38, P586, DOI 10.1037/hea0000764
   National Center for Health Statistics, 2008, NAT HLTH NUTR EX SUR
   Oh J, 2019, J AFFECT DISORDERS, V257, P623, DOI 10.1016/j.jad.2019.06.034
   Oren DA, 2002, BIOL PSYCHIAT, V51, P422, DOI 10.1016/S0006-3223(01)01254-9
   Patel V, 2018, WORLD PSYCHIATRY, V17, P76, DOI 10.1002/wps.20492
   Pickett KE, 2015, SOC SCI MED, V128, P316, DOI 10.1016/j.socscimed.2014.12.031
   Rhee SJ, 2014, PROG NEURO-PSYCHOPH, V54, P223, DOI 10.1016/j.pnpbp.2014.06.006
   Ribeiro WS, 2017, LANCET PSYCHIAT, V4, P554, DOI 10.1016/S2215-0366(17)30159-1
   Roberts RE, 2000, AM J EPIDEMIOL, V152, P163, DOI 10.1093/aje/152.2.163
   Sartorius N, 2018, DIALOGUES CLIN NEURO, V20, P47
   Schnyer DM, 2017, PSYCHIAT RES-NEUROIM, V264, P1, DOI 10.1016/j.pscychresns.2017.03.003
   Schulman J.H., 1997, BIOSENS BIOELECTRON, V11
   Shafiee M, 2017, PSYCHONEUROENDOCRINO, V84, P101, DOI 10.1016/j.psyneuen.2017.06.021
   Sheikh N, 2004, ACTA MED IRANICA, V42, P185
   Simon GE, 2001, WESTERN J MED, V175, P292, DOI 10.1136/ewjm.175.5.292
   Simon GE, 2008, GEN HOSP PSYCHIAT, V30, P32, DOI 10.1016/j.genhosppsych.2007.09.001
   Singh M, 2020, SCI REP-UK, V10, P1
   Siracusa MC, 2013, J ALLERGY CLIN IMMUN, V132, P789, DOI 10.1016/j.jaci.2013.07.046
   Steel JL, 2010, J PAIN SYMPTOM MANAG, V39, P859, DOI 10.1016/j.jpainsymman.2009.09.019
   STOCKER R, 1987, SCIENCE, V235, P1043, DOI 10.1126/science.3029864
   Sutin AR, 2010, BIOL PSYCHOL, V84, P186, DOI 10.1016/j.biopsycho.2010.01.012
   Swift SL, 2020, J EPIDEMIOL COMMUN H, V74, P995, DOI 10.1136/jech-2020-213917
   Taft TH, 2019, J ASTHMA ALLERGY, V12, P389, DOI 10.2147/JAA.S193045
   Tang WK, 2013, PSYCHIAT CLIN NEUROS, V67, P259, DOI 10.1111/pcn.12051
   Tashakori A., 2016, Adv. Med., V2016
   Toker S, 2008, DEPRESS ANXIETY, V25, P661, DOI 10.1002/da.20379
   Viinamäki H, 2009, ACTA PSYCHIAT SCAND, V120, P23, DOI 10.1111/j.1600-0447.2008.01333.x
   Weinstein AA, 2011, PSYCHOSOMATICS, V52, P127, DOI 10.1016/j.psym.2010.12.019
   Wilkinson R, 2017, LANCET PSYCHIAT, V4, P512, DOI 10.1016/S2215-0366(17)30206-7
   Williams DR, 2018, J HEALTH SOC BEHAV, V59, P466, DOI 10.1177/0022146518814251
   Yamaguchi T, 2002, BIOCHEM BIOPH RES CO, V293, P517, DOI 10.1016/S0006-291X(02)00233-4
   Youssef NA, 2013, LIVER INT, V33, P1062, DOI 10.1111/liv.12165
   Zheng P, 2012, J PROTEOME RES, V11, P1741, DOI 10.1021/pr2010082
NR 77
TC 15
Z9 17
U1 5
U2 26
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD AUG
PY 2021
VL 140
BP 364
EP 372
DI 10.1016/j.jpsychires.2021.05.070
EA JUN 2021
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA TQ5OX
UT WOS:000678330600016
PM 34144440
DA 2025-06-11
ER

PT J
AU Grozdan, AM
   Ghiuru, R
   Duceac, LD
   Bodescu, MM
AF Grozdan, Ana Minodora
   Ghiuru, Rodica
   Duceac, Letitia Doina
   Bodescu, Maria Madalina
TI The Prevention of the Risk of Depression at Metabolic Syndrome Patients
   by Making a Minimum Hepatic Investigation
SO REVISTA DE CHIMIE
LA English
DT Article
DE depresion; risk factors; alcohol use; metabolic syndrome; hepatic
   steatosis
AB Depression is a mental disorder characterized by a deep change state of the thymus, disposition, in the sense of sadness, suffering and moral inhibition psychomotor generally associating with psychoactive substance dependence. An association in particular alcoholism and other psychiatric disorders was noticed more decades. Obesity many of the SML may determine, outside taps organ important psychological imbalances, linked both to aesthetics. If the connection between S M and cardiovascular disease has been studied in detail, the correlation between S M and the emergence of depressive episodes prospects remains an NIS. The aim of the study was to determine a minimum package Biochemical investigations of liver function in patients with MS need notice for preventing risk of depression, the study objective was to demonstrate the involvement consumption both alcohol and depressive episodes in the development of steatosis hepatic. Consuming Alcohol was shown to be the central element both in depression and Development Department hepatic steatosis, MS patients have increased risk of developing hepatic steatosis by lipid metabolic changes involve them this nosological entity. Additional alcohol is a factor that can increase the risk of steatosis and depression.
C1 [Grozdan, Ana Minodora; Ghiuru, Rodica; Duceac, Letitia Doina] Apollonia Univ Iasi, 2 Muzicii Str, Iasi 700399, Romania.
   [Bodescu, Maria Madalina] Gr T Popa Univ Med & Pharm, 16 Univ Str, Iasi 700115, Romania.
   [Ghiuru, Rodica] Clin Hosp CF Iasi, Iasi, Romania.
   [Duceac, Letitia Doina] Children Emergency Hosp St Mary Iasi, Iasi, Romania.
C3 Apollonia University; Grigore T Popa University of Medicine & Pharmacy
RP Duceac, LD (corresponding author), Apollonia Univ Iasi, 2 Muzicii Str, Iasi 700399, Romania.; Duceac, LD (corresponding author), Children Emergency Hosp St Mary Iasi, Iasi, Romania.
EM letimedr@yahoo.com
RI Duceac, Letitia/HPD-9900-2023
OI Duceac, Letita Doina/0000-0001-6868-8014
CR APETREI E., 2009, REV ROMANA CARDIOLOG, VXIV, P165
   Coleman RL, 2007, DIABETES CARE, V30, P1292, DOI 10.2337/dc06-1358
   Hurjui DM, 2012, MED-SURG J, V116, P425
   IRINA COTEA, 2013, ROMYEARSAN J ORAL RE, V5, P75
   Mihalache L, 2012, MED-SURG J, V116, P794
   MITU F., 2009, INFLAMMATION METABOL, VVI, P33
   MITU F., 2009, SINDROMUL METABOLIC, P13
   MUNTEANU D, 2014, TRADIPII I ORIENTARI, P87
   Nita C, 2009, METAB SYNDR RELAT D, V7, P105, DOI 10.1089/met.2008.0039
   Steinberger J, 2009, CIRCULATION, V119, P628, DOI 10.1161/CIRCULATIONAHA.108.191394
NR 10
TC 2
Z9 2
U1 0
U2 5
PU CHIMINFORM DATA S A
PI BUCHAREST
PA CALEA PLEVNEI NR 139, SECTOR 6, BUCHAREST R-77131, ROMANIA
SN 0034-7752
J9 REV CHIM-BUCHAREST
JI Rev. Chim.
PD DEC
PY 2016
VL 67
IS 12
BP 2654
EP 2658
PG 5
WC Chemistry, Multidisciplinary; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering
GA EJ5BB
UT WOS:000393230400055
DA 2025-06-11
ER

PT J
AU East, C
   Willis, BL
   Barlow, CE
   Grannemann, BD
   FitzGerald, SJ
   DeFina, LF
   Trivedi, MH
AF East, Cara
   Willis, Benjamin L.
   Barlow, Carolyn E.
   Grannemann, Bruce D.
   FitzGerald, Shannon J.
   DeFina, Laura F.
   Trivedi, Madhukar H.
TI Depressive Symptoms and Metabolic Syndrome in Preventive Healthcare: The
   Cooper Center Longitudinal Study
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID MIDDLE-AGED WOMEN; PHYSICAL-ACTIVITY; OLDER-ADULTS; MAJOR DEPRESSION;
   DOSE-RESPONSE; MENTAL-HEALTH; FOLLOW-UP; CES-D; ASSOCIATION; MANAGEMENT
AB Background: Depression, metabolic syndrome, and reduced cardiorespiratory fitness (CRF) are known to increase the risk of developing diabetes and cardiovascular disease. The association among these factors in a generally healthy, active population with access to health care is not well defined.
   Methods: This was a cross-sectional analysis of data collected on 5,125 women and men during preventive care examinations at the Cooper Clinic from 2000 to 2008. The main outcome measures were depressive symptoms as assessed by the Centers for Epidemiologic Studies Depression Scale short form (CES-D-10) questionnaire, presence or absence of metabolic syndrome, and CRF as measured by a maximal exercise treadmill test.
   Results: Women and men who exhibited depressive symptoms had a statistically higher prevalence of metabolic syndrome compared to those who did not (for women, 15.4% versus 7.2%, P < 0.0001; for men, 31.6% versus 22.8%, P < 0.0001). Individuals with depressive symptoms had an increased frequency of higher waist circumference, higher triglycerides, and lower high-density lipoprotein. Women with depressive symptoms also had marginally higher fasting blood glucose levels. After adjusting for age and smoking status, the odds of metabolic syndrome in women with depressive symptoms was 2.81 [95% confidence interval (CI), 2.01-3.93] times the odds of metabolic syndrome in those without depressive symptoms, and in men with depressive symptoms, the odds were 1.69 (95% CI, 1.42-2.00) times the odds of metabolic syndrome in men without. When controlled for CRF level, the presence or absence of depressive symptoms on the presence of metabolic syndrome is attenuated but remains statistically significant in women.
   Conclusion: Even in a generally healthy population with access to health care, the presence of depressive symptoms was associated with increased metabolic syndrome.
C1 [Willis, Benjamin L.; Barlow, Carolyn E.; FitzGerald, Shannon J.; DeFina, Laura F.] Cooper Inst, Dallas, TX 75230 USA.
   [East, Cara] Baylor Jack & Jane Hamilton Heart & Vasc Hosp, Soltero Cardiovasc Res Ctr, Dallas, TX USA.
   [Grannemann, Bruce D.; Trivedi, Madhukar H.] Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA.
C3 Cooper Institute; University of Texas System; University of Texas
   Southwestern Medical Center Dallas
RP DeFina, LF (corresponding author), Cooper Inst, 12330 Preston Rd, Dallas, TX 75230 USA.
EM ldefina@cooperinst.org
RI wright, beth/V-7496-2019; Trivedi, Madhukar/A-9029-2013
OI Trivedi, Madhukar/0000-0002-2983-1110
FU Agency for Healthcare Research and Quality (AHRQ); Corcept Therapeutics,
   Inc.; Corcept Therapeutics, Inc., Cyberonics, Inc.; Merck; National
   Alliance for Research in Schizophrenia and Depression; National
   Institute of Mental Health; National Institute on Drug Abuse; Novartis;
   Pharmacia Upjohn; Predix Pharmaceuticals (Epix); Solvay Pharmaceuticals,
   Inc.; Targacept; Abbott Laboratories, Inc.; Abdi Ibrahim; Akzo (Organon
   Pharmaceuticals Inc.); AstraZeneca; Bristol-Myers Squibb Company;
   Cephalon, Inc.; Evotec; Fabre Kramer Pharmaceuticals, Inc.; Forest
   Pharmaceuticals; GlaxoSmithKline; Janssen Pharmaceutica Products; LP;
   Johnson Johnson PRD; Eli Lilly Company; Meade Johnson; Medtronic;
   Neuronetics; Otsuka Pharmaceuticals; Parke-Davis Pharmaceuticals, Inc.;
   Pfizer Inc.; Sepracor; SHIRE Development; VantagePoint; Wyeth-Ayerst
   Laboratories
FX Dr. Trivedi reports that he has received research support from the
   Agency for Healthcare Research and Quality (AHRQ), Corcept Therapeutics,
   Inc., Cyberonics, Inc., Merck, National Alliance for Research in
   Schizophrenia and Depression, National Institute of Mental Health,
   National Institute on Drug Abuse, Novartis, Pharmacia & Upjohn, Predix
   Pharmaceuticals (Epix), Solvay Pharmaceuticals, Inc., and Targacept. He
   has received consulting and speaker fees from Abbott Laboratories, Inc.,
   Abdi Ibrahim, Akzo (Organon Pharmaceuticals Inc.), AstraZeneca,
   Bristol-Myers Squibb Company, Cephalon, Inc., Evotec, Fabre Kramer
   Pharmaceuticals, Inc., Forest Pharmaceuticals, GlaxoSmithKline, Janssen
   Pharmaceutica Products, LP, Johnson & Johnson PRD, Eli Lilly & Company,
   Meade Johnson, Medtronic, Neuronetics, Otsuka Pharmaceuticals,
   Parke-Davis Pharmaceuticals, Inc., Pfizer Inc., Sepracor, SHIRE
   Development, VantagePoint, and Wyeth-Ayerst Laboratories.
CR Akbaraly TN, 2009, DIABETES CARE, V32, P499, DOI 10.2337/dc08-1358
   Allison DB, 2009, AM J PREV MED, V36, P341, DOI 10.1016/j.amepre.2008.11.020
   ANDRESEN EM, 1994, AM J PREV MED, V10, P77, DOI 10.1016/S0749-3797(18)30622-6
   [Anonymous], 2000, ACSMS GUIDELINES EXE
   Blaine B, 2008, J HEALTH PSYCHOL, V13, P1190, DOI 10.1177/1359105308095977
   Blumenthal JA, 2007, PSYCHOSOM MED, V69, P587, DOI 10.1097/PSY.0b013e318148c19a
   Brown LC, 2005, DIABETES CARE, V28, P1063, DOI 10.2337/diacare.28.5.1063
   Brown WJ, 2005, AM J PREV MED, V29, P265, DOI 10.1016/j.amepre.2005.06.009
   Carnethon MR, 2007, ARCH INTERN MED, V167, P802, DOI 10.1001/archinte.167.8.802
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   Dunn AL, 2005, AM J PREV MED, V28, P1, DOI 10.1016/j.amepre.2004.09.003
   Dunn AL, 2001, MED SCI SPORT EXER, V33, pS587, DOI 10.1097/00005768-200106001-00027
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   Galper DI, 2006, MED SCI SPORT EXER, V38, P173, DOI 10.1249/01.mss.0000180883.32116.28
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Golden SH, 2008, JAMA-J AM MED ASSOC, V299, P2751, DOI 10.1001/jama.299.23.2751
   Grundy SM, 2004, CIRCULATION, V109, P551, DOI 10.1161/01.CIR.0000112379.88385.67
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Irwin M, 1999, ARCH INTERN MED, V159, P1701, DOI 10.1001/archinte.159.15.1701
   Keller MB, 2001, J CLIN PSYCHIAT, V62, P3
   Kessler RC, 2005, ARCH GEN PSYCHIAT, V62, P617, DOI 10.1001/archpsyc.62.6.617
   Kohout F J, 1993, J Aging Health, V5, P179, DOI 10.1177/089826439300500202
   Kornstein SG, 2001, J CLIN PSYCHIAT, V62, P11
   Krishnan KRR, 2000, AM HEART J, V140, P570, DOI 10.1067/mhj.2000.109980
   LaMonte MJ, 2005, CIRCULATION, V112, P505, DOI 10.1161/CIRCULATIONAHA.104.503805
   Lett HS, 2004, PSYCHOSOM MED, V66, P305, DOI 10.1097/01.psy.0000126207.43307.c0
   Lichtman JH, 2008, CIRCULATION, V118, P1768, DOI 10.1161/CIRCULATIONAHA.108.190769
   Mead GE, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004366.pub4
   Murphy JM, 2000, ARCH GEN PSYCHIAT, V57, P209, DOI 10.1001/archpsyc.57.3.209
   POLLOCK ML, 1976, AM HEART J, V92, P39, DOI 10.1016/S0002-8703(76)80401-2
   Pulkki-Råback L, 2009, HEALTH PSYCHOL, V28, P108, DOI 10.1037/a0012646
   Simon GE, 2008, GEN HOSP PSYCHIAT, V30, P32, DOI 10.1016/j.genhosppsych.2007.09.001
   Strawbridge WJ, 2002, AM J EPIDEMIOL, V156, P328, DOI 10.1093/aje/kwf047
   Takeuchi T, 2009, DIABETES METAB, V35, P32, DOI 10.1016/j.diabet.2008.06.006
   Trivedi Madhukar H, 2006, J Psychiatr Pract, V12, P205, DOI 10.1097/00131746-200607000-00002
   Tuunainen A, 2001, PSYCHIAT RES, V103, P261, DOI 10.1016/S0165-1781(01)00278-5
   Uher R, 2009, BRIT J PSYCHIAT, V195, P202, DOI 10.1192/bjp.bp.108.061960
   van Gool CH, 2007, AM J PUBLIC HEALTH, V97, P887, DOI 10.2105/AJPH.2004.053199e
   Vanhala M, 2009, ACTA PSYCHIAT SCAND, V119, P137, DOI 10.1111/j.1600-0447.2008.01283.x
   Vogelzangs N, 2009, AM J GERIAT PSYCHIAT, V17, P716, DOI 10.1097/JGP.0b013e3181aad5d7
   Weber-Hamann B, 2006, PSYCHONEUROENDOCRINO, V31, P347, DOI 10.1016/j.psyneuen.2005.08.014
NR 41
TC 20
Z9 27
U1 0
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD OCT
PY 2010
VL 8
IS 5
BP 451
EP 457
DI 10.1089/met.2010.0017
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA 662LS
UT WOS:000282809400011
PM 20854094
DA 2025-06-11
ER

PT J
AU Lee, AMH
   Ng, CG
   Koh, OH
   Gill, JS
   Aziz, SA
AF Lee, Albert Muh Haur
   Ng, Chong Guan
   Koh, Ong Hui
   Gill, Jesjeet Singh
   Aziz, Salina Abdul
TI Metabolic Syndrome in First Episode Schizophrenia, Based on the National
   Mental Health Registry of Schizophrenia (NMHR) in a General Hospital in
   Malaysia: A 10-Year Retrospective Cohort Study
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE metabolic syndrome; schizophrenia; risk
ID PHYSICAL-ACTIVITY; SUBSTANCE-ABUSE; DRUG-NAIVE; VITAMIN-D; GLUCOSE;
   1ST-EPISODE; POPULATION; DEPRESSION; MORTALITY; DISEASE
AB Schizophrenia has been linked with various medical comorbidities, particularly metabolic syndrome. The number of studies on this aspect is lacking in Malaysia. (1) Objective: To investigate metabolic syndrome rates and its associated factors. (2) Method: This is the first 10-year retrospective-outcome study of patients with first episode schizophrenia in Malaysia. Out of 394 patients diagnosed with first episode schizophrenia and registered with the National Mental Health Registry of Schizophrenia (NMHR) in the General Hospital Kuala Lumpur (GHKL) in 2004-2005, 174 patients consented to participate in the study. They were interviewed using a Schizophrenia outcome questionnaire and the International Physical Activity Questionnaire (IPAQ). The diagnosis of metabolic syndrome was made using the National Cholesterol Education ProgramThird Adult Treatment Panel (NCEP ATP III). (3) Results: All patients' weight, body mass index, fasting blood sugar, and blood pressure are significantly increased. Sixty-three subjects (36.2%) developed metabolic syndrome while 36 (23.2%) were hypertensive, and 41 (28.1%) were diabetic. Use of fluphenthixol depot (CI = 1.05-5.09, OR: 0.84, p = 0.039), reduced physical activity (CI = 0.13-1.00, OR: -1.04, p = 0.049), and substance use disorder (CI = 1.40, 13.89, OR: 1.48, p = 0.012) were significantly associated with metabolic syndrome based on univariate analysis. In further multivariate analysis, comorbid substance abuse was the only significant factor associated with metabolic syndrome after adjusting for physical activity and intramuscular depot. (4) Conclusion: Patients with schizophrenia are at high risk of metabolic syndrome. It is important to address substance use problems as an important risk factor of this comorbidity.
C1 [Lee, Albert Muh Haur; Aziz, Salina Abdul] Hosp Kuala Lumpur, Dept Psychiat, Kuala Lumpur 50586, Malaysia.
   [Ng, Chong Guan; Koh, Ong Hui; Gill, Jesjeet Singh] Univ Malaya, Dept Psychol Med, Fac Med, Kuala Lumpur 50603, Malaysia.
C3 Universiti Malaya
RP Ng, CG (corresponding author), Univ Malaya, Dept Psychol Med, Fac Med, Kuala Lumpur 50603, Malaysia.
EM albert_imu@hotmail.com; chong_guan@um.edu.my; ohkoh@um.edu.my;
   jesjeet@um.edu.my; salinaziz@gmail.com
RI Ng, Chong/G-6170-2010; , Koh/B-8798-2010; Gill, Jesjeet
   Singh/B-8709-2010
OI Ng, Chong Guan/0000-0003-1755-9188; , Koh/0000-0001-7455-4178; Gill,
   Jesjeet Singh/0000-0002-1594-0084
CR Aasheim ET, 2008, AM J CLIN NUTR, V87, P362, DOI 10.1093/ajcn/87.2.362
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alexander CM, 2003, DIABETES, V52, P1210, DOI 10.2337/diabetes.52.5.1210
   ALLEBECK P, 1989, SCHIZOPHRENIA BULL, V15, P81, DOI 10.1093/schbul/15.1.81
   Amer Diabet Assoc, 2004, DIABETES CARE, V27, P596, DOI 10.2337/diacare.27.2.596
   Botella-Carretero JI, 2007, CLIN NUTR, V26, P573, DOI 10.1016/j.clnu.2007.05.009
   Brown S, 1999, PSYCHOL MED, V29, P697, DOI 10.1017/S0033291798008186
   Brunzell JD, 2003, AM J MED, V115, P24, DOI 10.1016/j.amjmed.2003.08.011
   Buckley PF, 2009, SCHIZOPHRENIA BULL, V35, P383, DOI 10.1093/schbul/sbn135
   Collins AA, 1996, SCHIZOPHR RES, V20, P205, DOI 10.1016/0920-9964(95)00107-7
   Compton MT, 2011, J CLIN PSYCHIAT, V72, P225, DOI 10.4088/JCP.09m05704yel
   Correll CU, 2006, J CLIN PSYCHIAT, V67, P575, DOI 10.4088/JCP.v67n0408
   Damms-Machado A, 2012, OBES SURG, V22, P881, DOI 10.1007/s11695-012-0609-0
   De Hert M, 2009, WORLD PSYCHIATRY, V8, P15
   de Vegt F, 2001, JAMA-J AM MED ASSOC, V285, P2109, DOI 10.1001/jama.285.16.2109
   Dixon L, 1999, SCHIZOPHR RES, V35, pS93, DOI 10.1016/S0920-9964(98)00161-3
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Hamamoto DT, 2009, ORAL DIS, V15, P27, DOI 10.1111/j.1601-0825.2008.01459.x
   Hennekens CH, 2005, AM HEART J, V150, P1115, DOI 10.1016/j.ahj.2005.02.007
   Holmberg SK, 1999, PSYCHIATR SERV, V50, P827, DOI 10.1176/ps.50.6.827
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Hunt GE, 2002, SCHIZOPHR RES, V54, P253, DOI 10.1016/S0920-9964(01)00261-4
   Ilanne-Parikka P, 2010, DIABETES CARE, V33, P1610, DOI 10.2337/dc09-2155
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Katzmarzyk PT, 2003, MED SCI SPORT EXER, V35, P1703, DOI 10.1249/01.MSS.0000089337.73244.9B
   Knapp M, 2004, SCHIZOPHRENIA BULL, V30, P279, DOI 10.1093/oxfordjournals.schbul.a007078
   KRAUCHI K, 1984, BRAIN RES, V321, P83, DOI 10.1016/0006-8993(84)90683-8
   Lakka TA, 2007, APPL PHYSIOL NUTR ME, V32, P76, DOI 10.1139/h06-113
   McClung JP, 2009, NUTR REV, V67, P100, DOI 10.1111/j.1753-4887.2008.00145.x
   McGurk SR, 2009, SCHIZOPHRENIA BULL, V35, P319, DOI 10.1093/schbul/sbn182
   Mohamud WNW, 2011, DIABETES RES CLIN PR, V91, P239, DOI 10.1016/j.diabres.2010.11.025
   Nead KG, 2004, PEDIATRICS, V114, P104, DOI 10.1542/peds.114.1.104
   Newcomer JW, 2007, AM J MANAG CARE, V13, pS170
   Newcomer JW, 2007, J CLIN PSYCHIAT, V68, P8
   PATE RR, 1995, JAMA-J AM MED ASSOC, V273, P402, DOI 10.1001/jama.273.5.402
   Ryan MCM, 2003, AM J PSYCHIAT, V160, P284, DOI 10.1176/appi.ajp.160.2.284
   Sands JR, 1999, SCHIZOPHRENIA BULL, V25, P157, DOI 10.1093/oxfordjournals.schbul.a033362
   Siris SG, 2001, SCHIZOPHR RES, V47, P185, DOI 10.1016/S0920-9964(00)00135-3
   Stern MP, 2004, DIABETES CARE, V27, P2676, DOI 10.2337/diacare.27.11.2676
   Trevisan M, 1998, AM J EPIDEMIOL, V148, P958
   Vancampfort D, 2013, WORLD PSYCHIATRY, V12, P240, DOI 10.1002/wps.20069
   von Hausswolff-Juhlin Y, 2009, ACTA PSYCHIAT SCAND, V119, P15, DOI 10.1111/j.1600-0447.2008.01309.x
   Williams GC, 1998, DIABETES CARE, V21, P1644, DOI 10.2337/diacare.21.10.1644
   Wortsman J, 2000, AM J CLIN NUTR, V72, P690, DOI 10.1093/ajcn/72.3.690
   Zhang YY, 2017, BMC PSYCHIATRY, V17, DOI 10.1186/s12888-017-1539-0
   Zisook S, 1999, AM J PSYCHIAT, V156, P1736
   Zorick T, 2010, ADDICTION, V105, P1809, DOI 10.1111/j.1360-0443.2010.03066.x
NR 48
TC 13
Z9 14
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD MAY
PY 2018
VL 15
IS 5
AR 933
DI 10.3390/ijerph15050933
PG 13
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA GJ3LS
UT WOS:000435197300101
PM 29735938
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Onat, A
   Ademoglu, E
   Karadeniz, Y
   Can, G
   Uzun, AO
   Simsek, B
   Kaya, A
AF Onat, Altan
   Ademoglu, Evin
   Karadeniz, Yusuf
   Can, Gunay
   Uzun, Ahmet Okan
   Simsek, Baris
   Kaya, Aysem
TI Population-based serum omentin-1 levels: paradoxical association with
   cardiometabolic disorders primarily in men
SO BIOMARKERS IN MEDICINE
LA English
DT Article; Proceedings Paper
CT 44th Congress of the International-Society-of-Oncology-and-Biomarkers
   (ISOBM)
CY SEP 07-10, 2017
CL Rio de Janeiro, BRAZIL
SP Int Soc Oncol & Biomarkers, European Grp Tumor Markers, Brazilian Soc Clin Pathol
DE autoimmunity; cardiometabolic risk; gender difference; lipoprotein(a);
   metabolic syndrome; omentin-1
ID METABOLIC SYNDROME; ADIPOSE-TISSUE; PLASMA-LEVELS; AUTOIMMUNE
   ACTIVATION; ADIPONECTIN LEVELS; CORONARY-DISEASE; HDL DYSFUNCTION; RISK;
   OBESITY; WOMEN
AB Aim: The conflicting relationships of serum omentin with inflammation markers and cardiometabolic disorders were investigated. Results & methods: Unselected 864 population-based middle-aged adults were cross-sectionally studied by sex-specific omentin tertiles. Men in the lowest omentin tertile (T1) had lower systolic blood pressure, HbA1c and glucose values and tended in T3 to higher lipoprotein(a) levels. Logistic regression analysis, adjusted for four covariates, revealed significant independent associations with the presence of hypertension and diabetes only in men. Sex-and age-adjusted odds ratio in gender combined for T2 & T3 versus T1 was 1.34 (95% CI: 1.00-1.79) for metabolic syndrome. Discussion & conclusion: The elicited adverse relationships of omentin-1 support the notion of oxidative stress-induced proinflammatory conversion of omentin, rendering loss of anti-inflammatory properties.
C1 [Onat, Altan] Istanbul Univ, Cerrahpasa Med Fac, Dept Cardiol, Istanbul, Turkey.
   [Ademoglu, Evin] Istanbul Univ, Istanbul Med Fac, Dept Biochem, Istanbul, Turkey.
   [Karadeniz, Yusuf] Ataturk Univ, Med Fac, Dept Endocrinol & Metab, Erzurum, Turkey.
   [Can, Gunay] Istanbul Univ, Cerrahpasa Med Fac, Dept Publ Hlth, Istanbul, Turkey.
   [Uzun, Ahmet Okan] State Hosp, Dept Cardiol, Antakya, Turkey.
   [Simsek, Baris] Siyami Ersek Ctr Cardiovasc Surg, Istanbul, Turkey.
   [Kaya, Aysem] Istanbul Univ, Inst Cardiol, Biochem Lab, Istanbul, Turkey.
C3 Istanbul University - Cerrahpasa; Istanbul University; Istanbul
   University; Ataturk University; Istanbul University; Istanbul University
   - Cerrahpasa; Dr. Siyami Ersek Cardiac & Vascular Surgery Training &
   Research Hospital; Istanbul University
RP Kaya, A (corresponding author), Istanbul Univ, Inst Cardiol, Biochem Lab, Istanbul, Turkey.
EM kaya64@istanbul.edu.tr
RI Karadeniz, Yusuf/JAC-5120-2023; Kaya, Aysem/N-4974-2015; Can,
   Günay/AAB-1669-2020; Ademoglu, Evin/AAD-8990-2020
OI Ademoglu, Evin/0000-0003-2933-3119; CAN, GUNAY/0000-0001-5815-6700;
   Kaya, Aysem/0000-0003-3137-821X; Karadeniz, Yusuf/0000-0002-6113-3259
FU Turkish Society of Cardiology, Istanbul, Turkey
FX Unconditional financial support was obtained from the Turkish Society of
   Cardiology, Istanbul, Turkey. The authors have no other relevant
   affiliations or financial involvement with any organization or entity
   with a financial interest in or financial conflict with the subject
   matter or materials discussed in the manuscript apart from those
   disclosed.
CR [Anonymous], 1982, CARDIOVASCULAR SURVE
   Batista CMDS, 2007, DIABETES, V56, P1655, DOI 10.2337/db06-1506
   Cantarini L, 2011, CLIN EXP RHEUMATOL, V29, P1044
   Caricilli AM, 2014, CURR OPIN CLIN NUTR, V17, P312, DOI 10.1097/MCO.0000000000000067
   Genuth S, 2003, DIABETES CARE, V26, P3160
   Jialal I, 2013, J CLIN ENDOCR METAB, V98, pE514, DOI 10.1210/jc.2012-3673
   Kazama K, 2012, EUR J PHARMACOL, V686, P116, DOI 10.1016/j.ejphar.2012.04.033
   Lapointe M, 2014, CARDIOVASC DIABETOL, V13, DOI 10.1186/s12933-014-0124-9
   Liu R, 2011, DIABETES RES CLIN PR, V93, P21, DOI 10.1016/j.diabres.2011.03.001
   Menzel J, 2016, ATHEROSCLEROSIS, V251, P415, DOI 10.1016/j.atherosclerosis.2016.06.003
   Narumi T, 2014, CARDIOVASC DIABETOL, V13, DOI 10.1186/1475-2840-13-84
   Onat A, 2015, EXP CLIN ENDOCR DIAB, V123, P11, DOI 10.1055/s-0034-1385922
   Onat A, 2002, ATHEROSCLEROSIS, V165, P285, DOI 10.1016/S0021-9150(02)00236-8
   Onat A, 2001, ATHEROSCLEROSIS, V156, P1, DOI 10.1016/S0021-9150(01)00500-7
   Onat A, 2008, CORONARY ARTERY DIS, V19, P125, DOI 10.1097/MCA.0b013e3282f399cf
   Onat A, 2016, EXPERT REV CARDIOVAS, V14, P513, DOI 10.1586/14779072.2016.1150782
   Onat A, 2014, CURR PHARM DESIGN, V20, P575, DOI 10.2174/138161282004140213145551
   Onat A, 2013, CLIN RHEUMATOL, V32, P1767, DOI 10.1007/s10067-013-2339-7
   Onat A, 2013, WORLD J DIABETES, V4, P219, DOI 10.4239/wjd.v4.i5.219
   Onat A, 2013, ANATOL J CARDIOL, V13, P543, DOI 10.5152/akd.2013.175
   Oswiecimska J, 2015, PHYSIOL RES, V64, P701, DOI 10.33549/physiolres.932841
   Pan HY, 2010, DIABETES RES CLIN PR, V88, P29, DOI 10.1016/j.diabres.2010.01.013
   Panagiotou G, 2014, METABOLISM, V63, P1265, DOI 10.1016/j.metabol.2014.06.001
   Satman I, 2013, EUR J EPIDEMIOL, V28, P169, DOI 10.1007/s10654-013-9771-5
   Schäffler A, 2005, BBA-GENE STRUCT EXPR, V1732, P96, DOI 10.1016/j.bbaexp.2005.11.005
   Shibata R, 2012, DIABETOL METAB SYNDR, V4, DOI 10.1186/1758-5996-4-37
   Tang YL, 2017, GYNECOL ENDOCRINOL, V33, P244, DOI 10.1080/09513590.2016.1254180
   Tohidi M, 2012, BONE, V51, P876, DOI 10.1016/j.bone.2012.08.117
   Vu A, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-4
   Wittenbecher C, 2016, DIABETES CARE, V39, pE79, DOI 10.2337/dc15-2702
   Yang RZ, 2006, AM J PHYSIOL-ENDOC M, V290, pE1253, DOI 10.1152/ajpendo.00572.2004
   Yoo HJ, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-103
   Zhang C, 2015, ARCH DERMATOL RES, V307, P455, DOI 10.1007/s00403-015-1549-z
   Zhang TP, 2016, CYTOKINE, V86, P15, DOI 10.1016/j.cyto.2016.07.008
NR 34
TC 6
Z9 6
U1 0
U2 11
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1752-0363
EI 1752-0371
J9 BIOMARK MED
JI Biomark. Med.
PD FEB
PY 2018
VL 12
IS 2
BP 141
EP 149
DI 10.2217/bmm-2017-0197
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Research & Experimental Medicine
GA FU7DW
UT WOS:000424013300007
PM 29327600
DA 2025-06-11
ER

PT J
AU Lopresti, AL
   Drummond, PD
AF Lopresti, Adrian L.
   Drummond, Peter D.
TI Obesity and psychiatric disorders: Commonalities in dysregulated
   biological pathways and their implications for treatment
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Inflammation; Neuroprogression; Obesity; Oxidative stress; Psychiatric
   disorders; Weight loss
ID BODY-MASS INDEX; FAST-FOOD CONSUMPTION; SEVERE MENTAL-ILLNESS; INDUCED
   WEIGHT-GAIN; OXIDATIVE STRESS; NITROSATIVE STRESS; PHYSICAL-ACTIVITY;
   METABOLIC SYNDROME; BIPOLAR DISORDER; CALORIC RESTRICTION
AB Rates of obesity are higher than normal across a range of psychiatric disorders, including major depressive disorder, bipolar disorder, schizophrenia and anxiety disorders. While the problem of obesity is generally acknowledged in mental health research and treatment, an understanding of their bi-directional relationship is still developing. In this review the association between obesity and psychiatric disorders is summarised, with a specific emphasis on similarities in their disturbed biological pathways; namely neurotransmitter imbalances, hypothalamus-pituitary-adrenal axis disturbances, dysregulated inflammatory pathways, increased oxidative and nitrosative stress, mitochondrial disturbances, and neuroprogression. The applicability and effectiveness of weight-loss interventions in psychiatric populations are reviewed along with their potential efficacy in ameliorating disturbed biological pathways, particularly those mediating inflammation and oxidative stress. It is proposed that weight loss may not only be an effective intervention to enhance physical health but may also improve mental health outcomes and slow the rate of neuroprogressive disturbances in psychiatric disorders. Areas of future research to help expand our understanding of the relationship between obesity and psychiatric disorders are also outlined. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Lopresti, Adrian L.; Drummond, Peter D.] Murdoch Univ, Sch Psychol, Perth, WA 6150, Australia.
C3 Murdoch University
RP Lopresti, AL (corresponding author), A 4-165 Summerlakes Pde Ballajura, Ballajura, WA 6066, Australia.
EM a.lopresti@murdoch.edu.au
OI Lopresti, Adrian/0000-0002-6409-7839
CR Aballay LR, 2013, NUTR REV, V71, P168, DOI 10.1111/j.1753-4887.2012.00533.x
   Abi-Dargham A, 2004, INT J NEUROPSYCHOPH, V7, pS1, DOI 10.1017/S1461145704004110
   Alappat L, 2010, NUTR REV, V68, P729, DOI 10.1111/j.1753-4887.2010.00341.x
   Allison DB, 2009, AM J PREV MED, V36, P341, DOI 10.1016/j.amepre.2008.11.020
   Altamura AC, 2013, PROG NEURO-PSYCHOPH, V42, P63, DOI 10.1016/j.pnpbp.2012.08.015
   Anderson G, 2013, PROG NEURO-PSYCHOPH, V42, P1, DOI 10.1016/j.pnpbp.2012.10.008
   Anderson G, 2013, PROG NEURO-PSYCHOPH, V42, P101, DOI 10.1016/j.pnpbp.2012.07.016
   Anderson G, 2013, PROG NEURO-PSYCHOPH, V42, P5, DOI 10.1016/j.pnpbp.2012.06.014
   [Anonymous], PROG NEUROPSYCHOPHAR
   [Anonymous], MOL PSYCHIAT
   [Anonymous], J OBES
   [Anonymous], OBES SURG
   [Anonymous], J AFFECT DISORD
   [Anonymous], SLEEP MED REV
   [Anonymous], J CLIN PSYCHIAT
   [Anonymous], HUM BRAIN MAPP
   [Anonymous], CLIN SCHIZOPHR RELAT
   Bailey BW, 2007, AM J HEALTH PROMOT, V21, P492, DOI 10.4278/0890-1171-21.6.492
   Berk M, 2011, NEUROSCI BIOBEHAV R, V35, P804, DOI 10.1016/j.neubiorev.2010.10.001
   Berkowitz RI, 2011, PSYCHIAT CLIN N AM, V34, P747, DOI 10.1016/j.psc.2011.08.007
   Boesing F, 2010, OBES SURG, V20, P1236, DOI 10.1007/s11695-010-0196-x
   Bonfioli E, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-78
   Bougoulia Maria, 2006, Hormones (Athens), V5, P192
   Boynton-Jarrett R, 2012, PEDIATRICS, V130, P245, DOI 10.1542/peds.2011-1554
   Brandacher G, 2007, CURR DRUG METAB, V8, P289, DOI 10.2174/138920007780362590
   Breslau N, 2002, CAN J PSYCHIAT, V47, P923, DOI 10.1177/070674370204701003
   Breum L, 2003, AM J CLIN NUTR, V77, P1112, DOI 10.1093/ajcn/77.5.1112
   Carpiniello B, 2012, EAT WEIGHT DISORD-ST, V17, pE259, DOI 10.3275/8809
   Chen CK, 2009, PSYCHIAT CLIN NEUROS, V63, P17, DOI 10.1111/j.1440-1819.2008.01886.x
   Church TS, 2010, MED SCI SPORT EXER, V42, P708, DOI 10.1249/MSS.0b013e3181c03a43
   Collin M, 2000, MOL BRAIN RES, V81, P51, DOI 10.1016/S0169-328X(00)00167-4
   Cousins DA, 2009, BIPOLAR DISORD, V11, P787, DOI 10.1111/j.1399-5618.2009.00760.x
   Cowen PJ, 2008, TRENDS PHARMACOL SCI, V29, P433, DOI 10.1016/j.tips.2008.05.004
   D'Argenio A, 2009, PHYSIOL BEHAV, V98, P543, DOI 10.1016/j.physbeh.2009.08.010
   Da Silva MA, 2012, EUR J EPIDEMIOL, V27, P537, DOI 10.1007/s10654-012-9692-8
   Dantzer R, 2011, PSYCHONEUROENDOCRINO, V36, P426, DOI 10.1016/j.psyneuen.2010.09.012
   Das UN, 2001, NUTRITION, V17, P953, DOI 10.1016/S0899-9007(01)00672-4
   Daumit GL, 2011, INT J OBESITY, V35, P1114, DOI 10.1038/ijo.2010.224
   Daumit GL, 2003, J NERV MENT DIS, V191, P799, DOI 10.1097/01.nmd.0000100923.20188.2d
   De Luca V, 2007, INT J NEUROPSYCHOPH, V10, P697, DOI 10.1017/S1461145707007547
   Deng C, 2010, PROG NEURO-PSYCHOPH, V34, P1, DOI 10.1016/j.pnpbp.2009.11.009
   Dent R, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0036889, 10.1371/journal.pone.0037135]
   Dickerson FB, 2006, SCHIZOPHRENIA BULL, V32, P584, DOI 10.1093/schbul/sbj048
   Dodd S, 2013, PROG NEURO-PSYCHOPH, V42, P135, DOI 10.1016/j.pnpbp.2012.11.007
   Dortland AKBV, 2013, PSYCHOSOM MED, V75, P83, DOI 10.1097/PSY.0b013e318274d30f
   Duclos M, 2001, CLIN ENDOCRINOL, V55, P447, DOI 10.1046/j.1365-2265.2001.01384.x
   Eller T, 2008, PROG NEURO-PSYCHOPH, V32, P445, DOI 10.1016/j.pnpbp.2007.09.015
   Ellingrod VL, 2007, PSYCHOPHARMACOL BULL, V40, P57
   Fabricatore AN, 2011, INT J OBESITY, V35, P1363, DOI 10.1038/ijo.2011.2
   Faulconbridge LF, 2012, OBESITY, V20, P783, DOI 10.1038/oby.2011.315
   Faulconbridge LF, 2011, J OBES, V2011, DOI 10.1155/2011/870385
   Floyd RA, 1999, P SOC EXP BIOL MED, V222, P236, DOI 10.1046/j.1525-1373.1999.d01-140.x
   Fotuhi M, 2012, NAT REV NEUROL, V8, P189, DOI 10.1038/nrneurol.2012.27
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gabriele JM, 2009, OBES REV, V10, P442, DOI 10.1111/j.1467-789X.2009.00570.x
   Gautam Shiv, 2011, Indian J Psychiatry, V53, P128, DOI 10.4103/0019-5545.82537
   Goldstein BI, 2011, BIPOLAR DISORD, V13, P387, DOI 10.1111/j.1399-5618.2011.00932.x
   Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
   Grimm ER, 2011, NUTR REV, V69, P52, DOI 10.1111/j.1753-4887.2010.00361.x
   Gunstad J, 2006, PSYCHIAT RES, V142, P31, DOI 10.1016/j.psychres.2005.11.007
   Hsiao Pao Ying, 2011, Journal of Nutrition in Gerontology and Geriatrics, V30, P204, DOI 10.1080/21551197.2011.591266
   Illán-Gómez F, 2012, OBES SURG, V22, P950, DOI 10.1007/s11695-012-0643-y
   Imayama I, 2012, CANCER RES, V72, P2314, DOI 10.1158/0008-5472.CAN-11-3092
   Jacka FN, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-149
   Jagust W, 2005, ARCH NEUROL-CHICAGO, V62, P1545, DOI 10.1001/archneur.62.10.1545
   Jeffery RW, 2009, APPETITE, V52, P238, DOI 10.1016/j.appet.2008.08.008
   Karasu Sylvia R, 2012, Am J Psychother, V66, P111
   Kemp DE, 2010, BIPOLAR DISORD, V12, P404, DOI 10.1111/j.1399-5618.2010.00823.x
   Khan A, 2007, J AFFECT DISORDERS, V99, P101, DOI 10.1016/j.jad.2006.08.027
   Kiecolt-Glaser JK, 2010, PSYCHOSOM MED, V72, P113, DOI 10.1097/PSY.0b013e3181cb9377
   Kim E, 2008, J CLIN PSYCHOPHARM, V28, P138, DOI 10.1097/JCP.0b013e31816777f7
   Krystal AD, 2008, ANN CLIN PSYCHIATRY, V20, P39, DOI 10.1080/10401230701844661
   Kuzelová H, 2010, NEUROENDOCRINOL LETT, V31, P4
   Leger D, 2000, J SLEEP RES, V9, P35, DOI 10.1046/j.1365-2869.2000.00178.x
   Leonard B, 2012, NEUROSCI BIOBEHAV R, V36, P764, DOI 10.1016/j.neubiorev.2011.12.005
   Leonard BE, 2012, J PSYCHOPHARMACOL, V26, P33, DOI 10.1177/0269881111431622
   Linde JA, 2011, ANN BEHAV MED, V41, P119, DOI 10.1007/s12160-010-9232-2
   Lopresti AL, 2012, J PSYCHOPHARMACOL, V26, P1512, DOI 10.1177/0269881112458732
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Maayan L, 2010, NEUROPSYCHOPHARMACOL, V35, P1520, DOI 10.1038/npp.2010.21
   Madsen EL, 2008, EUR J ENDOCRINOL, V158, P179, DOI 10.1530/EJE-07-0721
   Maes M, 2011, PROG NEURO-PSYCHOPH, V35, P702, DOI 10.1016/j.pnpbp.2010.12.017
   Maes M, 2011, NEUROENDOCRINOL LETT, V32, P7
   Magalhaes PV, 2011, REV BRAS PSIQUIATR, V33, P374, DOI 10.1590/S1516-44462011000400011
   Maina G, 2008, J AFFECT DISORDERS, V110, P149, DOI 10.1016/j.jad.2007.12.233
   Malhi GS, 2012, AUST NZ J PSYCHIAT, V46, P192, DOI 10.1177/0004867412437346
   Malone M, 2011, OBES SURG, V21, P1721, DOI 10.1007/s11695-010-0351-4
   McElroy SL, 2009, J CLIN PSYCHIAT, V70, P12, DOI 10.4088/JCP.7075su1c.03
   Menza M, 2004, J CLIN PSYCHIAT, V65, P471
   Moylan S, 2013, NEUROSCI BIOBEHAV R, V37, P573, DOI 10.1016/j.neubiorev.2013.02.003
   Müller DJ, 2013, CURR OPIN PSYCHIATR, V26, P144, DOI 10.1097/YCO.0b013e32835dc9da
   Müller N, 2008, CURR PHARM DESIGN, V14, P1452, DOI 10.2174/138161208784480243
   Myint AM, 2012, FEBS J, V279, P1375, DOI 10.1111/j.1742-4658.2012.08551.x
   Myint AM, 2012, J NEURAL TRANSM, V119, P245, DOI 10.1007/s00702-011-0741-3
   Newcomer JW, 2005, CNS DRUGS, V19, P1
   Nicklas BJ, 2004, AM J CLIN NUTR, V79, P544
   Noble EE, 2011, AM J PHYSIOL-REG I, V300, pR1053, DOI 10.1152/ajpregu.00776.2010
   O'Brien SM, 2007, J PSYCHIAT RES, V41, P326, DOI 10.1016/j.jpsychires.2006.05.013
   Ozcelik O, 2005, TOHOKU J EXP MED, V206, P313, DOI 10.1620/tjem.206.313
   Pakiz B, 2011, INT J BEHAV MED, V18, P333, DOI 10.1007/s12529-010-9079-8
   Papakostas GI, 2005, INT J NEUROPSYCHOPH, V8, P59, DOI 10.1017/S1461145704004602
   Pendlebury J, 2007, ACTA PSYCHIAT SCAND, V115, P286, DOI 10.1111/j.1600-0447.2006.00906.x
   Petry NM, 2008, PSYCHOSOM MED, V70, P288, DOI 10.1097/PSY.0b013e3181651651
   Power C, 2007, BIOL RES NURS, V8, P223, DOI 10.1177/1099800406292674
   Raison CL, 2013, JAMA PSYCHIAT, V70, P31, DOI 10.1001/2013.jamapsychiatry.4
   Raji CA, 2010, HUM BRAIN MAPP, V31, P353, DOI 10.1002/hbm.20870
   Rivenes AC, 2009, J PSYCHOSOM RES, V66, P269, DOI 10.1016/j.jpsychores.2008.07.012
   Rogge MM, 2009, BIOL RES NURS, V10, P356, DOI 10.1177/1099800408329408
   Rosenheck R, 2008, OBES REV, V9, P535, DOI 10.1111/j.1467-789X.2008.00477.x
   Rotella F, 2013, J CLIN PSYCHIAT, V74, P32, DOI 10.4088/JCP.12r07922
   Rummel-Kluge C, 2010, SCHIZOPHR RES, V123, P225, DOI 10.1016/j.schres.2010.07.012
   Rutledge T, 2012, OBES SURG, V22, P1734, DOI 10.1007/s11695-012-0722-0
   Sagud M, 2010, PSYCHIAT DANUB, V22, P270
   Salehi M, 2005, HORM METAB RES, V37, P193, DOI 10.1055/s-2005-861374
   Salim S, 2012, ADV PROTEIN CHEM STR, V88, P1, DOI 10.1016/B978-0-12-398314-5.00001-5
   Sánchez-Villegas A, 2012, PUBLIC HEALTH NUTR, V15, P424, DOI 10.1017/S1368980011001856
   Sánchez-Villegas A, 2009, ARCH GEN PSYCHIAT, V66, P1090, DOI 10.1001/archgenpsychiatry.2009.129
   Sanderson K, 2011, AUST NZ J PSYCHIAT, V45, P384, DOI 10.3109/00048674.2011.570309
   Scapagnini G, 2012, CNS DRUGS, V26, P477, DOI 10.2165/11633190-000000000-00000
   Schröder H, 2007, BRIT J NUTR, V98, P1274, DOI 10.1017/S0007114507781436
   Schwartz E, 2012, NAT MED, V18, P496, DOI 10.1038/nm.2716
   Seeman P, 2009, J PSYCHIATR NEUROSCI, V34, P143
   Serretti A, 2010, J CLIN PSYCHIAT, V71, P1259, DOI 10.4088/JCP.09r05346blu
   Shelton RC, 2010, PROG NEUROBIOL, V91, P275, DOI 10.1016/j.pneurobio.2010.04.004
   Snel M, 2011, FOOD CHEM TOXICOL, V49, P3104, DOI 10.1016/j.fct.2011.09.032
   Soczynska JK, 2011, NEUROMOL MED, V13, P93, DOI 10.1007/s12017-010-8140-8
   Song MR, 2012, PUBLIC HEALTH NURS, V29, P208, DOI 10.1111/j.1525-1446.2011.00986.x
   Steele D, 2012, PERSPECT PSYCHIATR C, V48, P125, DOI 10.1111/j.1744-6163.2012.00333.x
   Steinmann WC, 2011, OBES SURG, V21, P1323, DOI 10.1007/s11695-011-0373-6
   Svec F, 2002, NUTR NEUROSCI, V5, P321, DOI 10.1080/1028415021000033785
   Taki Y, 2008, OBESITY, V16, P119, DOI 10.1038/oby.2007.4
   Templeman Lucy A, 2005, Pharmacogenet Genomics, V15, P195, DOI 10.1097/01213011-200504000-00002
   Tucker LA, 2011, OBESITY, V19, P1950, DOI 10.1038/oby.2011.184
   Uher R, 2009, J AFFECT DISORDERS, V118, P147, DOI 10.1016/j.jad.2009.02.013
   Vieta E, 2013, EUR PSYCHIAT, V28, P21, DOI 10.1016/j.eurpsy.2011.11.007
   Vincent HK, 2007, DIABETES OBES METAB, V9, P813, DOI 10.1111/j.1463-1326.2007.00692.x
   Vreeland B, 2003, PSYCHIAT SERV, V54, P1155, DOI 10.1176/appi.ps.54.8.1155
   Wang GJ, 2009, J ADDICT MED, V3, P8, DOI 10.1097/ADM.0b013e31819a86f7
   Wang GJ, 2001, LANCET, V357, P354, DOI 10.1016/S0140-6736(00)03643-6
   Wehmeier PM, 2005, PSYCHIAT RES, V133, P273, DOI 10.1016/j.psychres.2004.02.018
   Wycherley TP, 2008, DIABETES OBES METAB, V10, P1062, DOI 10.1111/j.1463-1326.2008.00863.x
   Yau PL, 2012, PEDIATRICS, V130, pE856, DOI 10.1542/peds.2012-0324
   Yoshimura R, 2009, PROG NEURO-PSYCHOPH, V33, P722, DOI 10.1016/j.pnpbp.2009.03.020
   Zhang JP, 2012, J CLIN PSYCHOPHARM, V32, P458, DOI 10.1097/JCP.0b013e31825cccd2
NR 144
TC 182
Z9 203
U1 0
U2 51
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD AUG 1
PY 2013
VL 45
BP 92
EP 99
DI 10.1016/j.pnpbp.2013.05.005
PG 8
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 202RW
UT WOS:000323238300013
PM 23685202
DA 2025-06-11
ER

PT J
AU Guijarro, SF
   Garcia, CM
   Pomarol-Clotet, E
   Lopez, ENE
   Marti, MDB
   Cuadra, MAR
AF Fernandez Guijarro, Sara
   Miguel Garcia, Carolina
   Pomarol-Clotet, Edith
   Egea Lopez, Elena Nunilon
   Burjales Marti, Maria Dolors
   Rigol Cuadra, Maria Assumpta
TI Metabolic Syndrome Screening in People With Severe Mental Illness:
   Results From Two Spanish Community Mental Health Centers
SO JOURNAL OF THE AMERICAN PSYCHIATRIC NURSES ASSOCIATION
LA English
DT Article
DE metabolic syndrome; screening; psychiatric nursing; mental health
   nursing; severe mental illness
ID PHYSICAL HEALTH; LIFE-STYLE; SCHIZOPHRENIA; PREVALENCE; INTERVENTIONS;
   ADULTS; RISK; CARE; DEFINITION; CONSUMERS
AB BACKGROUND: The excess of mortality in people with severe mental illness is due to unnatural causes such as accidents or suicides and natural causes such as metabolic syndrome. The presence of modifiable risk factors like tobacco consumption increases cardiovascular and metabolic risk. AIMS: The purpose of this study was to identify the prevalence of metabolic syndrome and other cardiovascular risk factors in people with severe mental illness. This study also aimed to identify the prevalence of patients receiving treatment for any metabolic syndrome risk factor. METHOD: A cross-sectional descriptive study was performed. A total of 125 participants from two community mental health centers in Spain were recruited. RESULTS: More than half of the participants (58.4%) were active smokers. The prevalence of metabolic syndrome was 60%. A total of 16.8% received previous treatment for hypertension, 17.6% for hypertriglyceridemia, and 11.2% for diabetes. No differences were found between centers (22.7% vs. 18.7%, p = .9). CONCLUSIONS: The findings underscore the importance of monitoring the physical health of patients on antipsychotic therapy. The identification and management of cardiovascular and metabolic risks factors is an essential part of nursing care for people with severe mental illness. Mental health nurses are ideally positioned to carry out this task by performing physical health screening, health education, and lifestyle interventions.
C1 [Fernandez Guijarro, Sara] Ramon & Cajal Hosp, Madrid, Spain.
   [Miguel Garcia, Carolina; Rigol Cuadra, Maria Assumpta] Univ Barcelona, Barcelona, Spain.
   [Pomarol-Clotet, Edith] FIDMAG Hermanas Hosp Res Fdn, Barcelona, Spain.
   [Egea Lopez, Elena Nunilon] Murcia Hlth Serv, Murcia, Spain.
   [Burjales Marti, Maria Dolors] Rovira & Virgili Univ, Tarragona, Spain.
C3 Hospital Universitario Ramon y Cajal; University of Barcelona;
   Universitat Rovira i Virgili
RP Guijarro, SF (corresponding author), Ramon & Cajal Hosp, Ctr Salud Mental Barajas, Ave Gen 5, Madrid 28042, Spain.
EM s.fguijarro@hotmail.com
RI Fernández, Sara/AAH-1827-2019
OI Pomarol-Clotet, Edith/0000-0002-8159-8563; fernandez guijarro,
   sara/0000-0001-7013-8636
CR [Anonymous], 2015, WHO report on the global tobacco epidemic
   [Anonymous], 1987, MOD COMPR COMM BAS M
   Bernardo M, 2009, EUR PSYCHIAT, V24, P431, DOI 10.1016/j.eurpsy.2009.07.010
   Bernardo M., 2014, RECOMMENDATIONS MONI
   Bobes J, 2008, REV PSIQUIATR SALUD, V1, P26, DOI 10.1016/S1888-9891(08)72513-8
   Bressington DT, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-87
   Brunero S, 2009, INT J MENT HEALTH NU, V18, P144, DOI 10.1111/j.1447-0349.2009.00595.x
   Cabassa LJ, 2010, PSYCHIAT SERV, V61, P774, DOI 10.1176/ps.2010.61.8.774
   CatSalut, 2003, SPEC ATT PROGR SER M
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Community of Madrid, 2010, STRAT PLAN MENT HLTH
   Cortés Morales Benjamín, 2011, Rev. Asoc. Esp. Neuropsiq., V31, P303
   Council of Andalusia Health Department, 2011, HLTH PROM PEOPL SEV
   Daumit GL, 2013, NEW ENGL J MED, V368, P1594, DOI 10.1056/NEJMoa1214530
   De Hert M, 2009, EUR PSYCHIAT, V24, P412, DOI 10.1016/j.eurpsy.2009.01.005
   De Hert MA, 2006, SCHIZOPHR RES, V83, P87, DOI 10.1016/j.schres.2005.12.855
   De Hert M, 2012, CNS DRUGS, V26, P733, DOI 10.2165/11634500-000000000-00000
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   Edward KL, 2010, ARCH PSYCHIAT NURS, V24, P46, DOI 10.1016/j.apnu.2009.04.009
   Fernández RM, 2017, THEMATA, P13, DOI 10.12795/themata.2017.i56.1
   Fernández-Bergés D, 2012, REV ESP CARDIOL, V65, P241, DOI [10.1016/j.recesp.2011.10.015, 10.1016/j.rec.2011.10.017]
   Boreu QF, 2013, ATEN PRIM, V45, P141, DOI 10.1016/j.aprim.2012.10.010
   Happell B, 2014, INT J NURS STUD, V51, P236, DOI 10.1016/j.ijnurstu.2013.06.004
   Happell B, 2013, J CLIN NURS, V22, P2286, DOI 10.1111/j.1365-2702.2012.04325.x
   Happell B, 2012, INT J MENT HEALTH NU, V21, P236, DOI 10.1111/j.1447-0349.2012.00816.x
   HEATHERTON TF, 1991, BRIT J ADDICT, V86, P1119
   Joffre-Velazquez V. M., 2009, MED J GEN HOSP, V72, P41
   Lieberman JA, 2005, NEW ENGL J MED, V353, P1209, DOI 10.1056/NEJMoa051688
   Looijmans A, 2017, BMC PSYCHIATRY, V17, DOI 10.1186/s12888-017-1265-7
   Maj M, 2009, WORLD PSYCHIATRY, V8, P1
   McEvoy JP, 2005, SCHIZOPHR RES, V80, P19, DOI 10.1016/j.schres.2005.07.014
   Ministry of Labour and Social Affairs, 2007, MOD CAR PEOPL SEV ME
   National Collaborating Centre for Mental Health, 2014, Psychosis and schizophrenia in adults: treatment and management
   Nursing Care Advisory Committee, 2010, MAN PROC COMM MENT H
   Reynolds GP, 2010, PHARMACOL THERAPEUT, V125, P169, DOI 10.1016/j.pharmthera.2009.10.010
   Richards L, 2016, J PSYCHOSOC NURS MEN, V54, P46, DOI 10.3928/02793695-20151109-02
   Ruiz JS, 2008, ACTAS ESP PSIQUIATRI, V36, P251
   van Hasselt FM, 2013, INT J MENT HEALTH NU, V22, P249, DOI 10.1111/j.1447-0349.2012.00859.x
   van Meijel B, 2015, PERSPECT PSYCHIATR C, V51, P106, DOI 10.1111/ppc.12071
   Vera E. M., 2014, PRESENCIA, V10
   Zimmet P, 2005, REV ESP CARDIOL, V58, P1371, DOI 10.1016/S1885-5857(06)60742-1
NR 41
TC 7
Z9 8
U1 0
U2 9
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1078-3903
EI 1532-5725
J9 J AM PSYCHIAT NURSES
JI J. Am. Psych. Nurses Assoc.
PD MAR
PY 2020
VL 26
IS 2
BP 162
EP 171
DI 10.1177/1078390319826686
PG 10
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA LA3KY
UT WOS:000523850500005
PM 30741068
DA 2025-06-11
ER

PT J
AU Das, D
   Shruthi, NR
   Banerjee, A
   Jothimani, G
   Duttaroy, AK
   Pathak, S
AF Das, Diptimayee
   Shruthi, Nagainallur Ravichandran
   Banerjee, Antara
   Jothimani, Ganesan
   Duttaroy, Asim K. K.
   Pathak, Surajit
TI Endothelial dysfunction, platelet hyperactivity, hypertension, and the
   metabolic syndrome: molecular insights and combating strategies
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE metabolic syndrome; atherosclerotic cardiovascular disease;
   hypertension; endothelial dysfunction; platelet hyperactivity
ID FATTY LIVER-DISEASE; ALL-CAUSE MORTALITY; CARDIOVASCULAR RISK;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; MEDITERRANEAN DIET;
   CARDIOMETABOLIC RISK; BLOOD-PRESSURE; OBESITY; PREVALENCE
AB Metabolic syndrome (MetS) is a multifaceted condition that increases the possibility of developing atherosclerotic cardiovascular disease. MetS includes obesity, hypertension, dyslipidemia, hyperglycemia, endothelial dysfunction, and platelet hyperactivity. There is a concerning rise in the occurrence and frequency of MetS globally. The rising incidence and severity of MetS need a proactive, multipronged strategy for identifying and treating those affected. For many MetS patients, achieving recommended goals for healthy fat intake, blood pressure control, and blood glucose management may require a combination of medicine therapy, lifestyles, nutraceuticals, and others. However, it is essential to note that lifestyle modification should be the first-line therapy for MetS. In addition, MetS requires pharmacological, nutraceutical, or other interventions. This review aimed to bring together the etiology, molecular mechanisms, and dietary strategies to combat hypertension, endothelial dysfunction, and platelet dysfunction in individuals with MetS.
C1 [Das, Diptimayee; Shruthi, Nagainallur Ravichandran; Banerjee, Antara; Jothimani, Ganesan; Pathak, Surajit] Chettinad Acad Res & Educ, Chettinad Hosp & Res Inst, Fac Allied Hlth Sci, Kelambakkam, Tamil Nadu, India.
   [Duttaroy, Asim K. K.] Univ Oslo, Inst Med Sci, Fac Med, Dept Nutr, Oslo, Norway.
C3 University of Oslo
RP Pathak, S (corresponding author), Chettinad Acad Res & Educ, Chettinad Hosp & Res Inst, Fac Allied Hlth Sci, Kelambakkam, Tamil Nadu, India.; Duttaroy, AK (corresponding author), Univ Oslo, Inst Med Sci, Fac Med, Dept Nutr, Oslo, Norway.
EM a.k.duttaroy@medisin.uio.no; drsurajitpathak@care.edu.in
RI Duttaroy, Asim/J-9499-2016; Jothimani, Ganesan/AAG-4407-2020; Banerjee,
   Antara/AAH-4044-2020; Das, Diptimayee/LUY-3352-2024; Pathak,
   Surajit/AAH-4022-2020
OI Jothimani, Ganesan/0000-0003-3031-5620
CR Abete I, 2011, NUTR METAB CARDIOVAS, V21, pB1, DOI 10.1016/j.numecd.2011.05.001
   Achari AE, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18061321
   Aggarwal BB, 2010, ANNU REV NUTR, V30, P173, DOI 10.1146/annurev.nutr.012809.104755
   Ahmed M, 2022, J DIABETES METAB DIS, V21, P1011, DOI 10.1007/s40200-021-00965-2
   Akhlaghi M, 2020, NUTR RES REV, V33, P1, DOI 10.1017/S0954422419000155
   Al Ghouleh I, 2011, FREE RADICAL BIO MED, V51, P1271, DOI 10.1016/j.freeradbiomed.2011.06.011
   Anand David Alexander Victor, 2016, Pharmacogn Rev, V10, P84, DOI 10.4103/0973-7847.194044
   Arif M, 2019, HYPERTENS RES, V42, P1099, DOI 10.1038/s41440-019-0248-0
   Assinger A, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.01687
   Athyros VG, 2016, J DIABETES COMPLICAT, V30, P9, DOI 10.1016/j.jdiacomp.2015.07.012
   Axelsson AS, 2017, SCI TRANSL MED, V9, DOI 10.1126/scitranslmed.aah4477
   Azimova K, 2014, OCHSNER J, V14, P616
   Bahia L, 2007, ATHEROSCLEROSIS, V195, P138, DOI 10.1016/j.atherosclerosis.2006.09.003
   Barale C, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21020623
   Baskaran S, 2021, ANDROLOGIA, V53, DOI 10.1111/and.13577
   Bazzano LA, 2013, CURR HYPERTENS REP, V15, P694, DOI 10.1007/s11906-013-0390-z
   Beazer JD, 2022, J CLIN ENDOCR METAB, V107, pE2192, DOI 10.1210/clinem/dgab811
   Behera SK, 2018, BRIT J CLIN PHARMACO, V84, P1068, DOI 10.1111/bcp.13541
   Belmonte SL, 2011, CIRC RES, V109, P309, DOI 10.1161/CIRCRESAHA.110.231233
   Benincasa G, 2022, BIOCHEM PHARMACOL, V202, DOI 10.1016/j.bcp.2022.115108
   Bernardo BC, 2012, P NATL ACAD SCI USA, V109, P17615, DOI 10.1073/pnas.1206432109
   Blanco-Colio LM, 2007, AM HEART J, V153, P881, DOI 10.1016/j.ahj.2007.02.029
   Blüher M, 2019, NAT REV ENDOCRINOL, V15, P288, DOI 10.1038/s41574-019-0176-8
   Boots AW, 2008, EUR J PHARMACOL, V585, P325, DOI 10.1016/j.ejphar.2008.03.008
   Botta M, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19041197
   Bray PF, 2007, HEMATOL ONCOL CLIN N, V21, P633, DOI 10.1016/j.hoc.2007.06.002
   Bremer AA, 2014, METAB SYNDR RELAT D, V12, P493, DOI 10.1089/met.2014.1505
   Broeders MAW, 2000, CIRCULATION, V102, P677, DOI 10.1161/01.CIR.102.6.677
   Brouwers S, 2021, LANCET, V398, P249, DOI 10.1016/S0140-6736(21)00221-X
   Brown AA, 2001, AM J CLIN NUTR, V73, P673
   Bu YZ, 2022, J CELL MOL MED, V26, P4886, DOI 10.1111/jcmm.17519
   Cameron AJ, 2008, OBESITY, V16, P2707, DOI 10.1038/oby.2008.412
   Campinho P, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.00552
   Carmichael L, 2022, NUTR DIABETES, V12, DOI 10.1038/s41387-022-00209-z
   Castro-Barquero S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12102983
   Catoi AF, 2018, NUTRIENTS, V10, DOI 10.3390/nu10091199
   Chen KY, 2022, J AGR FOOD CHEM, V70, P5829, DOI 10.1021/acs.jafc.2c00555
   Chen SH, 2015, DIGEST LIVER DIS, V47, P226, DOI 10.1016/j.dld.2014.11.015
   Chimonas T, 2010, METAB SYNDR RELAT D, V8, P523, DOI 10.1089/met.2010.0023
   Chirkov YY, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23031042
   Chiva-Blanch G, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/5812401
   Choi KM, 2014, J NUTR BIOCHEM, V25, P201, DOI 10.1016/j.jnutbio.2013.10.007
   Ciarambino T, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10123067
   Ciavarella A, 2021, THROMB RES, V198, P139, DOI 10.1016/j.thromres.2020.12.002
   Cognasse F, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.01478
   Colvin BT, 2004, VOX SANG, V87, P43, DOI 10.1111/j.1741-6892.2004.00428.x
   Corrie L, 2021, LIFE SCI, V280, DOI 10.1016/j.lfs.2021.119753
   Cortese F, 2020, J HUM HYPERTENS, V34, P420, DOI 10.1038/s41371-020-0307-7
   Junho CVC, 2022, HEART FAIL REV, V27, P2137, DOI 10.1007/s10741-022-10218-w
   Cuspidi C, 2018, J HYPERTENS, V36, P1833, DOI 10.1097/HJH.0000000000001767
   Cutler JA, 2008, HYPERTENSION, V52, P818, DOI 10.1161/HYPERTENSIONAHA.108.113357
   Maués JHD, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8101256
   Dal Canto E, 2019, EUR J PREV CARDIOL, V26, P25, DOI 10.1177/2047487319878371
   Danese E, 2021, SEMIN THROMB HEMOST, V47, P53, DOI 10.1055/s-0040-1718400
   Daryabor G, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.01582
   Das D, 2022, J FOOD BIOCHEM, V46, DOI 10.1111/jfbc.14476
   Das RK, 2021, BMC NUTR, V7, DOI 10.1186/s40795-021-00485-5
   Davis C, 2015, NUTRIENTS, V7, P9139, DOI 10.3390/nu7115459
   Dayeh NR, 2016, PROG CARDIOVASC DIS, V59, P11, DOI 10.1016/j.pcad.2016.05.002
   de Figueiredo SM, 2015, RECENT PATENTS ENDOC, V9, P24, DOI 10.2174/1872214809666150505164138
   de Souza CG, 2012, J MED FOOD, V15, P795, DOI 10.1089/jmf.2012.0016
   Deanfield JE, 2007, CIRCULATION, V115, P1285, DOI 10.1161/CIRCULATIONAHA.106.652859
   DECKERT T, 1989, DIABETOLOGIA, V32, P219, DOI 10.1007/BF00285287
   Dhoble S, 2022, INT J PHARMACEUT, V621, DOI 10.1016/j.ijpharm.2022.121792
   Di Daniele N, 2017, ONCOTARGET, V8, P8947, DOI 10.18632/oncotarget.13553
   Digby JE, 2009, CURR OPIN LIPIDOL, V20, P321, DOI 10.1097/MOL.0b013e32832d3b9d
   Eslam M, 2020, NAT REV GASTRO HEPAT, V17, P40, DOI 10.1038/s41575-019-0212-0
   Esposito L, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/4936571
   Fantin F, 2021, DIABETES VASC DIS RE, V18, DOI 10.1177/14791641211047135
   Feenstra RGT, 2022, CIRC-CARDIOVASC INTE, V15, DOI 10.1161/CIRCINTERVENTIONS.122.012017
   Festa A, 1999, ARTERIOSCL THROM VAS, V19, P562, DOI 10.1161/01.ATV.19.3.562
   Franquesa M, 2019, NUTRIENTS, V11, DOI 10.3390/nu11030655
   Freedman JE, 2008, ARTERIOSCL THROM VAS, V28, pS11, DOI 10.1161/ATVBAHA.107.159178
   Gao J, 2022, J CARDIOVASC TRANSL, V15, P604, DOI 10.1007/s12265-021-10171-3
   Gao QN, 2021, BBA-MOL BASIS DIS, V1867, DOI 10.1016/j.bbadis.2020.166037
   Ge L, 2020, BMJ-BRIT MED J, V369, DOI 10.1136/bmj.m696
   Georgescu A, 2005, EUR J PHARMACOL, V508, P159, DOI 10.1016/j.ejphar.2004.11.043
   Gepstein V, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00568
   Giurgescu C, 2019, J URBAN HEALTH, V96, P23, DOI 10.1007/s11524-018-00341-1
   Silva IVG, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20143458
   Gómez-Arbeláez D, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/285795
   Gora IM, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10020314
   Gotsis E, 2015, ANGIOLOGY, V66, P304, DOI 10.1177/0003319714532169
   Greenberg B, 2016, GENE THER, V23, P313, DOI 10.1038/gt.2015.109
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Grundy SM, 2004, ARTERIOSCL THROM VAS, V24, pE19, DOI 10.1161/01.ATV.0000112379.88385.67
   Gu SX, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11050995
   Guerrero-Garcia Carolina, 2018, Drugs Context, V7, P212531, DOI 10.7573/dic.212531
   Gusev E, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22147582
   Hall JE, 2019, NAT REV NEPHROL, V15, P367, DOI 10.1038/s41581-019-0145-4
   Han TS, 2016, JRSM CARDIOVASC DIS, V5, DOI 10.1177/2048004016633371
   Hartikainen J, 2017, EUR HEART J, V38, P2547, DOI 10.1093/eurheartj/ehx352
   Higashi Y, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11101958
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Incalza MA, 2018, VASC PHARMACOL, V100, P1, DOI 10.1016/j.vph.2017.05.005
   Irfan M, 2020, J GINSENG RES, V44, P24, DOI 10.1016/j.jgr.2019.05.005
   Jamwal S, 2018, INFLAMM RES, V67, P391, DOI 10.1007/s00011-018-1129-8
   Joshi V, 2020, MED RES REV, V40, P1385, DOI 10.1002/med.21662
   Kahleova H, 2017, NUTRIENTS, V9, DOI 10.3390/nu9080848
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Katsimardou A, 2020, CURR HYPERTENS REV, V16, P12, DOI 10.2174/1573402115666190415161813
   Kaur R, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0763-3
   Kearney J, 2010, PHILOS T R SOC B, V365, P2793, DOI 10.1098/rstb.2010.0149
   Kervezee L, 2020, EUR J NEUROSCI, V51, P396, DOI 10.1111/ejn.14216
   Khalil CA, 2014, THER ADV CHRONIC DIS, V5, P178, DOI 10.1177/2040622314529325
   Khatana C, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/5245308
   Khwairakpam AD, 2020, J MOL MED, V98, P71, DOI 10.1007/s00109-019-01863-0
   Kim GT, 2014, INT J MOL MED, V33, P863, DOI 10.3892/ijmm.2014.1658
   Kim H, 2018, J NUTR, V148, P624, DOI 10.1093/jn/nxy019
   Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213
   Kim JH, 2020, CARDIOVASC DIABETOL, V19, DOI 10.1186/s12933-020-01025-4
   Kim Y, 2018, NUTRIENTS, V10, DOI 10.3390/nu10040390
   Kjeldsen SE, 2008, J HYPERTENS, V26, P2064, DOI 10.1097/HJH.0b013e32830c45c3
   Koenig-Oberhuber V, 2016, BRIT J ANAESTH, V117, P74, DOI 10.1093/bja/aew214
   Königstein K, 2021, J HYPERTENS, V39, P1361, DOI 10.1097/HJH.0000000000002798
   Kolluru GK, 2023, NAT REV CARDIOL, V20, P109, DOI 10.1038/s41569-022-00741-6
   Konukoglu D, 2017, ADV EXP MED BIOL, V956, P511, DOI 10.1007/5584_2016_90
   Kopp W, 2019, DIABET METAB SYND OB, V12, P2221, DOI 10.2147/DMSO.S216791
   Kreslová M, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10102614
   Krzeminska J, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11010172
   Kullo IJ, 2007, J AM COLL CARDIOL, V49, P1413, DOI 10.1016/j.jacc.2006.11.039
   Kurrelmeyer K., 1972, J AM MED WOMENS ASS, V58, P272
   Lacatusu CM, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16060942
   Lancellotti Stefano, 2019, BioMolecular Concepts, V10, P194, DOI 10.1515/bmc-2019-0022
   Landmesser U, 2004, CIRCULATION, V109, P27, DOI 10.1161/01.CIR.0000129501.88485.1f
   Leisegang MS, 2018, ANTIOXID REDOX SIGN, V29, P793, DOI 10.1089/ars.2017.7276
   Leoncini G, 2005, J INTERN MED, V257, P454, DOI 10.1111/j.1365-2796.2005.01468.x
   Li MW, 2022, SIGNAL TRANSDUCT TAR, V7, DOI 10.1038/s41392-022-01073-0
   Li ZH, 2014, NAT REV DRUG DISCOV, V13, P622, DOI 10.1038/nrd4359
   Liang SX, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10020341
   Liguori I, 2018, CLIN INTERV AGING, V13, P757, DOI 10.2147/CIA.S158513
   Lin YH, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20184497
   Liu Y., 2020, MEDRXIV, V2020, P2020
   López-Méndez I, 2021, NUTR RES, V87, P70, DOI 10.1016/j.nutres.2020.12.019
   Losso JN, 2022, MOLECULES, V27, DOI 10.3390/molecules27051623
   Lunyera J, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0201001
   Mahat RK, 2019, DIAB MET SYND CLIN R, V13, P2803, DOI 10.1016/j.dsx.2019.07.041
   Maheswaraiah A, 2015, PHYTOTHER RES, V29, P450, DOI 10.1002/ptr.5274
   Mallah MA, 2022, CHEMOSPHERE, V296, DOI 10.1016/j.chemosphere.2022.133948
   Mallat Z, 1999, CIRCULATION, V99, P348, DOI 10.1161/01.CIR.99.3.348
   Mallick R, 2022, MOL CELL BIOCHEM, V477, P15, DOI 10.1007/s11010-021-04260-9
   Man AWC, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/1496462
   Mancia G, 2007, HYPERTENSION, V49, P40, DOI 10.1161/01.HYP.0000251933.22091.24
   Mancusi C, 2020, HIGH BLOOD PRESS CAR, V27, P515, DOI 10.1007/s40292-020-00408-8
   Manz XD, 2022, AM J RESP CRIT CARE, V205, P806, DOI 10.1164/rccm.202109-2075OC
   Masselli E, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21144866
   Maurin N, 2010, MED KLIN, V105, P339, DOI 10.1007/s00063-010-1062-2
   McGuire S, 2016, ADV NUTR, V7, P202, DOI 10.3945/an.115.011684
   Melikian N, 2008, ATHEROSCLEROSIS, V197, P375, DOI 10.1016/j.atherosclerosis.2007.06.009
   Méndez-del Villar M, 2014, METAB SYNDR RELAT D, V12, P497, DOI 10.1089/met.2014.0082
   Meng DY, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.688643
   Miceli G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms232314914
   Miller JM, 2014, METAB SYNDR RELAT D, V12, P527, DOI 10.1089/met.2014.0055
   Misra A, 2008, J CLIN ENDOCR METAB, V93, pS9, DOI 10.1210/jc.2008-1595
   Misra A, 2019, CURR OBES REP, V8, P43, DOI 10.1007/s13679-019-0328-0
   Mittra S, 2008, DRUG DISCOV TODAY, V13, P211, DOI 10.1016/j.drudis.2008.01.006
   Nawi AM, 2021, INT J HYPERTENS, V2021, DOI 10.1155/2021/6657003
   Moller-Leimkuhler Anne Maria, 2007, Dialogues Clin Neurosci, V9, P71
   Mozaffarian D, 2016, CIRCULATION, V133, P187, DOI 10.1161/CIRCULATIONAHA.115.018585
   Muller DN, 2011, CURR OPIN NEPHROL HY, V20, P113, DOI 10.1097/MNH.0b013e3283436f88
   Na LX, 2013, MOL NUTR FOOD RES, V57, P1569, DOI 10.1002/mnfr.201200131
   Negi G, 2011, CURR NEUROVASC RES, V8, P294, DOI 10.2174/156720211798120972
   Nelson AJ, 2019, PROG CARDIOVASC DIS, V62, P306, DOI 10.1016/j.pcad.2019.07.001
   Neu CT, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21207614
   Neves KB, 2018, HYPERTENSION, V71, P638, DOI 10.1161/HYPERTENSIONAHA.117.10490
   O'Kennedy N, 2017, EUR J CLIN NUTR, V71, P723, DOI 10.1038/ejcn.2016.222
   O'Kennedy N, 2021, NUTRIENTS, V13, DOI 10.3390/nu13072184
   O'Kennedy N, 2021, MED HYPOTHESES, V147, DOI 10.1016/j.mehy.2020.110480
   O'Toole PW, 2020, J INTERN MED, V287, P271, DOI 10.1111/joim.13021
   Oelze M, 2006, HYPERTENSION, V48, P677, DOI 10.1161/01.HYP.0000239207.82326.29
   Oesterle A, 2017, CIRC RES, V120, P229, DOI 10.1161/CIRCRESAHA.116.308537
   Oger E, 2022, J CLIN HYPERTENS, V24, P438, DOI 10.1111/jch.14445
   Oprea AD, 2013, BRIT J ANAESTH, V111, P3, DOI 10.1093/bja/aet402
   Orbe J, 2009, ARTERIOSCL THROM VAS, V29, P2109, DOI 10.1161/ATVBAHA.109.194589
   Ostovar Rahim, 2017, Electron Physician, V9, P5402, DOI 10.19082/5402
   Padiya R, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-53
   Pannier B, 2008, J HYPERTENS, V26, P1223, DOI 10.1097/HJH.0b013e3282fd9936
   Park JH, 2020, KOREAN J FAM MED, V41, P365, DOI 10.4082/kjfm.20.0165
   Park S, 2019, ANN INTERN MED, V171, P875, DOI 10.7326/M19-0563
   Park-Windhol C, 2016, ANNU REV PATHOL-MECH, V11, P251, DOI 10.1146/annurev-pathol-012615-044506
   Pasini Anna Fratta, 2005, Journal of Hypertension, V23, P589, DOI 10.1097/01.hjh.0000160216.86597.ff
   Pedersen BK, 2006, SCAND J MED SCI SPOR, V16, P3, DOI 10.1111/j.1600-0838.2006.00520.x
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Pérez-Martínez P, 2017, NUTR REV, V75, P307, DOI 10.1093/nutrit/nux014
   Petrie JR, 2018, CAN J CARDIOL, V34, P575, DOI 10.1016/j.cjca.2017.12.005
   Peyter AC, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22136667
   Pfeuffer M, 2013, NUTR METAB CARDIOVAS, V23, P403, DOI 10.1016/j.numecd.2011.08.010
   Piatti P, 1996, DIABETES, V45, P316, DOI 10.2337/diabetes.45.3.316
   Popkin BM, 2006, AM J CLIN NUTR, V84, P289, DOI 10.1093/ajcn/84.2.289
   Prasad D S, 2012, J Cardiovasc Dis Res, V3, P204, DOI 10.4103/0975-3583.98895
   Puddu P, 2008, BLOOD PRESSURE, V17, P70, DOI 10.1080/08037050802029954
   Rahimi N, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01847
   Rahman K, 2016, J NUTR, V146, p410S, DOI 10.3945/jn.114.202408
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Reinhart KM, 2009, NUTR RES REV, V22, P39, DOI 10.1017/S0954422409350003
   Rivera L, 2008, OBESITY, V16, P2081, DOI 10.1038/oby.2008.315
   Rochette L, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11071226
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Rohde K, 2019, METABOLISM, V92, P37, DOI 10.1016/j.metabol.2018.10.007
   Rupaimoole R, 2017, NAT REV DRUG DISCOV, V16, P203, DOI 10.1038/nrd.2016.246
   Sanghera DK, 2019, DIABETES OBES METAB, V21, P1088, DOI 10.1111/dom.13641
   Satija A, 2018, TRENDS CARDIOVAS MED, V28, P437, DOI 10.1016/j.tcm.2018.02.004
   Sattar N, 2019, CIRCULATION, V139, P2228, DOI 10.1161/CIRCULATIONAHA.118.037885
   Savaré L, 2022, J HYPERTENS, V40, P1768, DOI 10.1097/HJH.0000000000003215
   Savoia C, 2011, EXPERT REV MOL MED, V13, P1, DOI 10.1017/S1462399411001815
   Schillaci G, 2004, J AM COLL CARDIOL, V43, P1817, DOI 10.1016/j.jacc.2003.12.049
   Schwartz B, 2014, FRONT ONCOL, V4, DOI 10.3389/fonc.2014.00164
   Scicchitano P, 2019, FREE RADICAL RES, V53, P579, DOI 10.1080/10715762.2019.1620939
   Senchenkova EY, 2019, CIRCULATION, V140, P319, DOI 10.1161/CIRCULATIONAHA.118.039345
   Sepp T, 2018, GLOBAL CHANGE BIOL, V24, P1452, DOI 10.1111/gcb.13969
   Sharifi-Rad M, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.00694
   Shenouda SM, 2011, CIRCULATION, V124, P444, DOI 10.1161/CIRCULATIONAHA.110.014506
   Shiferaw WS, 2020, DIAB MET SYND CLIN R, V14, P1403, DOI 10.1016/j.dsx.2020.07.013
   Silva LR, 2022, FOODS, V11, DOI 10.3390/foods11030336
   Siracusa DS., NEUROINFLAMMATION OX
   Sitia S, 2010, AUTOIMMUN REV, V9, P830, DOI 10.1016/j.autrev.2010.07.016
   Sleiman D, 2015, FRONT PUBLIC HEALTH, V3, DOI 10.3389/fpubh.2015.00069
   Smail HO, 2019, AIMS GENET, V6, P36, DOI 10.3934/genet.2019.3.36
   Smith CW, 2017, ARTERIOSCL THROM VAS, V37, P823, DOI 10.1161/ATVBAHA.117.309253
   Smith ZD, 2013, NAT REV GENET, V14, P204, DOI 10.1038/nrg3354
   Sobha Santhi Priya, 2022, Curr Aging Sci, V15, P282, DOI 10.2174/1874609815666220304193925
   Song MY, 2009, TOXICOL APPL PHARM, V235, P57, DOI 10.1016/j.taap.2008.11.007
   Sponton CH, 2022, TRENDS ENDOCRIN MET, V33, P587, DOI 10.1016/j.tem.2022.05.003
   Stasko J, 2022, EXPERT REV HEMATOL, V15, P53, DOI 10.1080/17474086.2022.2030217
   Steven S, 2015, INT J MOL SCI, V16, P18185, DOI 10.3390/ijms160818185
   Storniolo CE, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081880
   Stys Peter K, 2019, F1000Res, V8, DOI 10.12688/f1000research.20906.1
   Su MM, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11061085
   Suades R, 2012, THROMB HAEMOSTASIS, V108, P1208, DOI 10.1160/TH12-07-0486
   Sugamura K, 2011, FREE RADICAL BIO MED, V51, P978, DOI 10.1016/j.freeradbiomed.2011.05.004
   Sun HJ, 2016, LIFE SCI, V167, P6, DOI 10.1016/j.lfs.2016.11.005
   Szczuko M, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222111644
   Tejada S, 2017, CURR DRUG TARGETS, V18, P1477, DOI 10.2174/1389450117666161005150650
   Tertsunen HM, 2020, EUR J NUTR, V59, P3545, DOI 10.1007/s00394-020-02188-2
   Title LM, 2008, VASC MED, V13, P263, DOI 10.1177/1358863X08095154
   Toggweiler S, 2010, CLIN CARDIOL, V33, P746, DOI 10.1002/clc.20836
   Touyz RM, 2021, CIRC RES, V128, P803, DOI 10.1161/CIRCRESAHA.121.319181
   Tresserra-Rimbau A, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/1432071
   Triggle CR, 2020, CAN J PHYSIOL PHARM, V98, P415, DOI 10.1139/cjpp-2019-0677
   Ugwoke CK, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020847
   van der Meijden PEJ, 2012, J THROMB HAEMOST, V10, P1355, DOI 10.1111/j.1538-7836.2012.04758.x
   van der Meijden PEJ, 2019, NAT REV CARDIOL, V16, P166, DOI 10.1038/s41569-018-0110-0
   van Oosterom N, 2020, DRUGS, V80, P1889, DOI 10.1007/s40265-020-01413-w
   Venter C, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21218234
   Vignini A, 2017, NUTRITION, V42, P92, DOI 10.1016/j.nut.2017.06.013
   Watson T, 2008, ANTIOXID REDOX SIGN, V10, P1079, DOI 10.1089/ars.2007.1998
   Weitz JI, 2017, NEW ENGL J MED, V376, P1211, DOI 10.1056/NEJMoa1700518
   Widmer RJ, 2015, AM J MED, V128, P229, DOI 10.1016/j.amjmed.2014.10.014
   Wong A, 2021, J VASC RES, DOI 10.1159/000518787
   Xiao F, 2022, J MED VIROL, V94, P1967, DOI 10.1002/jmv.27556
   Xu JY, 2003, AM J PHYSIOL-GASTR L, V285, pG20, DOI 10.1152/ajpgi.00474.2002
   Xu L, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20235920
   Yalameha B, 2022, CLIN CHIM ACTA, V533, P63, DOI 10.1016/j.cca.2022.06.019
   Yi X, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/6023710
   You TJ, 2008, J GERONTOL A-BIOL, V63, P414, DOI 10.1093/gerona/63.4.414
   Zaric B, 2020, CURR MED CHEM, V27, P1021, DOI 10.2174/0929867326666190903112146
   Zermatten MG, 2020, HEPATOLOGY, V71, P2135, DOI 10.1002/hep.31201
   Zhang ZG, 2014, J MOL CELL CARDIOL, V77, P42, DOI 10.1016/j.yjmcc.2014.09.022
   Zhou Xiaoqin, 2017, J Evid Based Med, V10, P136, DOI 10.1111/jebm.12253
   Zhuo Q, 2012, NAT REV RHEUMATOL, V8, P729, DOI 10.1038/nrrheum.2012.135
   Zinkevich NS, 2011, AM J PHYSIOL-HEART C, V301, pH647, DOI 10.1152/ajpheart.01271.2010
   Zubcevic J, 2011, HYPERTENSION, V57, P1026, DOI 10.1161/HYPERTENSIONAHA.111.169748
NR 262
TC 31
Z9 31
U1 4
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD AUG 8
PY 2023
VL 10
AR 1221438
DI 10.3389/fnut.2023.1221438
PG 25
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA P6TC9
UT WOS:001051970900001
PM 37614749
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Haghighatdoost, F
   Azadbakht, L
   Keshteli, AH
   Feinle-Bisset, C
   Daghaghzadeh, H
   Afshar, H
   Feizi, A
   Esmaillzadeh, A
   Adibi, P
AF Haghighatdoost, Fahimeh
   Azadbakht, Leila
   Keshteli, Ammar Hassanzadeh
   Feinle-Bisset, Christine
   Daghaghzadeh, Hamed
   Afshar, Hamid
   Feizi, Awat
   Esmaillzadeh, Ahmad
   Adibi, Peyman
TI Glycemic index, glycemic load, and common psychological disorders
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE anxiety; depression; glycemic index; glycemic load; psychological
   distress
ID DEPRESSIVE SYMPTOMS; COGNITIVE PERFORMANCE; METABOLIC SYNDROME; GUT
   MICROBIOTA; MENTAL-HEALTH; DIET QUALITY; RISK-FACTORS; ASSOCIATION;
   METAANALYSIS; PREVALENCE
AB Background: Potential associations between dietary glycemic index (GI) and glycemic load (GL) with psychological disorders remain uncertain.
   Objective: We investigated the relations of dietary GI and GL with psychological distress, anxiety, and depression.
   Design: A total of 3363 nonacademic members of the staff of Isfahan University of Medical Sciences were included in this cross-sectional study. GI and GL were assessed by using a validated, self-administered, dish-based, semiquantitative food-frequency questionnaire. Validated Iranian versions of the Hospital Anxiety and Depression Scale and General Health Questionnaire-12 were used to assess anxiety, depression, and psychological distress.
   Results: After control for potential confounders, individuals in the top tertile of GI had greater odds of depression (OR: 1.44; 95% CI: 1.03, 2.02; P-trend = 0.03) and a trend for greater odds of anxiety (OR: 1.52; 95% CI: 0.97, 2.38; P trend = 0.06) compared with those in the first tertile. Higher GL values were linked to lower odds for mental disorders (OR: 0.66; 95% CI: 0.49, 0.90; P-trend = 0.009), depression (OR: 0.69; 95% CI: 0.51, 0.93; P-trend = 0.02), and psychological distress (OR: 0.67; 95% CI: 0.48, 0.92; P-trend = 0.01). Significant interactions were observed between GI and sex for depression (P = 0.01) and psychological distress (P = 0.046) in the crude model. In stratified analyses by sex, after control for potential confounders, a greater GI was linked to a higher odds of depression (OR: 1.52; 95% CI: 1.20, 1.94; P-trend = 0.001) and psychological distress (OR: 1.66; 95% CI: 1.28, 2.14; P-trend = 0.001) in women but not in men.
   Conclusion: Our findings support a direct link between the odds of depression and dietary GI but inverse associations between GL and mental disorders, depression, and psychological distress. This trial was registered at clinicaltrials.gov as NCT02362113.
C1 [Haghighatdoost, Fahimeh; Azadbakht, Leila; Esmaillzadeh, Ahmad] Isfahan Univ Med Sci, Food Secur Res Ctr, Esfahan, Iran.
   [Haghighatdoost, Fahimeh; Azadbakht, Leila] Isfahan Univ Med Sci, Dept Community Nutr, Sch Nutr & Food Sci, Esfahan, Iran.
   [Daghaghzadeh, Hamed; Afshar, Hamid; Adibi, Peyman] Isfahan Univ Med Sci, Integrat Funct Gastroenterol Res Ctr, Esfahan, Iran.
   [Feizi, Awat] Isfahan Univ Med Sci, Sch Hlth, Dept Biostat & Epidemiol, Esfahan, Iran.
   [Azadbakht, Leila] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Keshteli, Ammar Hassanzadeh] Univ Alberta, Dept Med, Edmonton, AB, Canada.
   [Feinle-Bisset, Christine] Univ Adelaide, Discipline Med, Adelaide, SA, Australia.
   [Feinle-Bisset, Christine] Univ Adelaide, Natl Hlth & Med Res Council, Ctr Res Excellence Translating Nutr Sci Good Hlth, Adelaide, SA, Australia.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Isfahan University of
   Medical Sciences; Tehran University of Medical Sciences; University of
   Alberta; University of Adelaide; National Health & Medical Research
   Council (NHMRC) of Australia; University of Adelaide
RP Azadbakht, L (corresponding author), Isfahan Univ Med Sci, Food Secur Res Ctr, Esfahan, Iran.
EM azadbakht@hlth.mui.ac.ir
RI afshar, hamid/AAC-7675-2020; Keshteli, Ammar/K-7473-2012; Adibi Sedeh,
   Peyman/AAJ-4582-2020; Azadbakht, Leila/N-2801-2018; daghaghzadeh,
   hamed/C-2133-2018; Esmaillzadeh, Ahmad/N-5704-2014; Feizi,
   Awat/W-3409-2017
OI Adibi Sedeh, Peyman/0000-0001-6411-5235; Azadbakht,
   Leila/0000-0002-5955-6818; daghaghzadeh, hamed/0000-0003-1259-7732;
   Hassanzadeh Keshteli, Ammar/0000-0001-7375-6210; Esmaillzadeh,
   Ahmad/0000-0002-8735-6047; Feizi, Awat/0000-0002-1930-0340
FU Isfahan University of Medical Sciences; National Health and Medical
   Research Council of Australia Senior Research Fellowship [627002]
FX Supported by Isfahan University of Medical Sciences. CF-B was supported
   by a National Health and Medical Research Council of Australia Senior
   Research Fellowship (grant 627002, 2010-15).
CR Adibi P, 2012, J RES MED SCI, V17, pS292
   Akbaraly TN, 2013, AM J CLIN NUTR, V97, P419, DOI 10.3945/ajcn.112.041582
   Akbaraly TN, 2009, BRIT J PSYCHIAT, V195, P408, DOI 10.1192/bjp.bp.108.058925
   ANANTH J, 1979, COMPR PSYCHIAT, V20, P475, DOI 10.1016/0010-440X(79)90034-8
   Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   Aparicio A, 2013, EUR J NUTR, V52, P1059, DOI 10.1007/s00394-012-0412-7
   Atkinson FS, 2008, DIABETES CARE, V31, P2281, DOI 10.2337/dc08-1239
   Barclay AW, 2008, AM J CLIN NUTR, V87, P627, DOI 10.1093/ajcn/87.3.627
   Brand-Miller J.C., 2007, NEW GLUCOSE REVOLUTI
   Buyken AE, 2014, AM J CLIN NUTR, V99, P813, DOI 10.3945/ajcn.113.074252
   Cameron IM, 2013, J AFFECT DISORDERS, V147, P262, DOI 10.1016/j.jad.2012.11.015
   Casper RC, 2011, WORLD REV NUTR DIET, V102, P98, DOI 10.1159/000327798
   Chan R, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0105760
   Cheatham RA, 2009, PHYSIOL BEHAV, V98, P374, DOI 10.1016/j.physbeh.2009.06.015
   Derakhshan F, 2013, CURR DIABETES REV, V9, P102
   Doré J, 2015, CURR OPIN BIOTECH, V32, P195, DOI 10.1016/j.copbio.2015.01.002
   Dortland AKBV, 2010, ACTA PSYCHIAT SCAND, V122, P30, DOI 10.1111/j.1600-0447.2010.01565.x
   Foster-Powell K, 2002, AM J CLIN NUTR, V76, P5, DOI 10.1093/ajcn/76.1.5
   Fung TT, 2002, AM J CLIN NUTR, V76, P535, DOI 10.1093/ajcn/76.3.535
   Ghaffarpour M, 1999, Tehran Nashre Olume Keshavarzy, V7, P42
   Haghighatdoost F, 2013, J AM COLL NUTR, V32, P111, DOI 10.1080/07315724.2013.767590
   Han QQ, 2014, NEUROSCI BULL, V30, P515, DOI 10.1007/s12264-013-1439-3
   Horan MK, 2014, EUR J CLIN NUTR, V68, P19, DOI 10.1038/ejcn.2013.212
   Hui LL, 2005, DIABETES CARE, V28, P2981, DOI 10.2337/diacare.28.12.2981
   Ingwersen J, 2007, APPETITE, V49, P240, DOI 10.1016/j.appet.2006.06.009
   Jacka FN, 2011, PSYCHOSOM MED, V73, P483, DOI 10.1097/PSY.0b013e318222831a
   Jacka FN, 2011, J AFFECT DISORDERS, V129, P332, DOI 10.1016/j.jad.2010.09.004
   Keshteli AH, 2014, INT J PREVENTIVE MED, V5, P29
   Kong LC, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0109434
   Konttinen H, 2010, APPETITE, V54, P473, DOI 10.1016/j.appet.2010.01.014
   Lamport DJ, 2013, CLIN NUTR, V32, P265, DOI 10.1016/j.clnu.2012.07.008
   Le Port A, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051593
   Li HL, 2011, AM J CLIN NUTR, V93, P101, DOI 10.3945/ajcn.110.003053
   Livesey G, 2013, AM J CLIN NUTR, V97, P584, DOI 10.3945/ajcn.112.041467
   Louie JCY, 2013, NUTR RES, V33, P259, DOI 10.1016/j.nutres.2013.02.008
   Ma YS, 2008, NUTRITION, V24, P45, DOI 10.1016/j.nut.2007.10.008
   Markus CR, 2007, BIOL PSYCHOL, V76, P83, DOI 10.1016/j.biopsycho.2007.06.003
   Michels N, 2012, APPETITE, V59, P762, DOI 10.1016/j.appet.2012.08.010
   Mojtabai R, 2011, AM J PUBLIC HEALTH, V101, P2156, DOI 10.2105/AJPH.2011.300258
   Montazeri Ali, 2003, Health Qual Life Outcomes, V1, P66, DOI 10.1186/1477-7525-1-66
   Montazeri Ali, 2003, Health Qual Life Outcomes, V1, P14, DOI 10.1186/1477-7525-1-14
   Moubarac JC, 2013, BMJ OPEN, V3, DOI 10.1136/bmjopen-2012-002298
   Murakami K, 2008, J AFFECT DISORDERS, V110, P174, DOI 10.1016/j.jad.2007.12.230
   Murphy JM, 2004, ACTA PSYCHIAT SCAND, V109, P355, DOI 10.1111/j.1600-0447.2003.00286.x
   Mwamburi DM, 2011, J AFFECT DISORDERS, V132, P94, DOI 10.1016/j.jad.2011.02.002
   Nazemi L, 2013, IRAN J PUBLIC HEALTH, V42, P559
   O'Doherty MG, 2012, INT J CANCER, V131, P1376, DOI 10.1002/ijc.27366
   Olesen J, 2012, EUR J NEUROL, V19, P155, DOI 10.1111/j.1468-1331.2011.03590.x
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Papanikolaou Y, 2006, DIABETOLOGIA, V49, P855, DOI 10.1007/s00125-006-0183-x
   Pasman WJ, 2003, INT J OBESITY, V27, P663, DOI 10.1038/sj.ijo.0802284
   Sampson TR, 2015, CELL HOST MICROBE, V17, P565, DOI 10.1016/j.chom.2015.04.011
   Sarris J, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/1471-244X-14-107
   Sobocki P, 2006, J MENT HEALTH POLICY, V9, P87
   Stunkard A., 1993, Obesity: Theory and therapy, V2nd
   Taleban F., 1999, GLYCEMIC INDEX VALUE, V1st
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
   WILLETT W, 1986, AM J EPIDEMIOL, V124, P17, DOI 10.1093/oxfordjournals.aje.a114366
   Willett W., 1998, NUTR EPIDEMIOLOGY, P101
   Wolever TMS, 2013, EUR J CLIN NUTR, V67, P522, DOI 10.1038/ejcn.2013.27
   Wolever TMS, 2006, AM J CLIN NUTR, V83, P1306, DOI 10.1093/ajcn/83.6.1306
   Yano JM, 2015, CELL, V161, P264, DOI 10.1016/j.cell.2015.02.047
   Zazpe I, 2014, BRIT J NUTR, V111, P2000, DOI 10.1017/S0007114513004364
NR 63
TC 64
Z9 67
U1 0
U2 29
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD JAN
PY 2016
VL 103
IS 1
BP 201
EP 209
DI 10.3945/ajcn.114.105445
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DA5VA
UT WOS:000367869500024
PM 26607943
OA Bronze
DA 2025-06-11
ER

PT J
AU He, JX
   Liu, F
   Xu, PY
   Xu, T
   Yu, HY
   Wu, BH
   Wang, HB
   Chen, J
   Zhang, K
   Zhang, JB
   Meng, KK
   Yan, XQ
   Yang, QS
   Zhang, XX
   Sun, D
   Chen, X
AF He, Jiaxuan
   Liu, Fan
   Xu, Peiye
   Xu, Ting
   Yu, Haiyang
   Wu, Baihui
   Wang, Hanbing
   Chen, Jia
   Zhang, Kun
   Zhang, Junbei
   Meng, Kaikai
   Yan, Xiaoqing
   Yang, Qinsi
   Zhang, Xingxing
   Sun, Da
   Chen, Xia
TI Aerobic Exercise Improves the Overall Outcome of Type 2 Diabetes
   Mellitus Among People With Mental Disorders
SO DEPRESSION AND ANXIETY
LA English
DT Review
DE aerobic exercise; mental disorders; nonpharmacological intervention;
   pathogenesis; type 2 diabetes mellitus
ID RANDOMIZED CONTROLLED-TRIAL; BIPOLAR-DISORDER; PHYSICAL-ACTIVITY;
   METABOLIC SYNDROME; COGNITIVE IMPAIRMENT; STRUCTURED EXERCISE;
   NEUROTROPHIC FACTOR; OXIDATIVE STRESS; GLYCEMIC CONTROL; HPA-AXIS
AB The escalating global prevalence of type 2 diabetes mellitus (T2DM) and mental disorder (MD) including schizophrenia, bipolar disorder, major depressive disorder, and anxiety highlights the urgency for comprehensive therapeutic strategies. Aerobic exercise (AE) is a viable adjunct therapy, providing significant benefits for individuals dealing with both T2DM and MD. This review consolidates evidence on AE's role in alleviating the physiological and psychological effects of these comorbid conditions. It delves into the pathophysiological connections between T2DM and various MD, including depression, schizophrenia, anxiety, and bipolar disorder-emphasizing their reciprocal exacerbation. Key neurophysiological mechanisms through which AE confers benefits are explored, including neuroinflammation modulation, brain structure and neuroplasticity enhancement, growth factor expression regulation, and hypothalamic-pituitary-adrenal (HPA)/microbiota-gut-brain (MGB) axis normalization. Clinical results indicate that AE significantly improves both metabolic and psychological parameters in patients with T2DM and MD, providing a substantial argument for integrating AE into comprehensive treatment plans. Future research should aim to establish detailed, personalized exercise prescriptions and explore the long-term benefits of AE in this population. This review underscores the potential of AE to complement existing therapeutic modalities and enhance the management of patients with T2DM and MD.
C1 [He, Jiaxuan; Liu, Fan; Xu, Peiye; Xu, Ting; Yu, Haiyang; Wu, Baihui; Sun, Da] Wenzhou Univ, Inst Life Sci & Biomed, Collaborat Innovat Ctr Zhejiang Prov, Wenzhou 325035, Peoples R China.
   [Wang, Hanbing] Univ Hong Kong, Dept Biotechnol, Hong Kong 999077, Peoples R China.
   [Chen, Jia] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sichuan Prov Ctr Mental Hlth, Sch Med, Chengdu 611100, Peoples R China.
   [Zhang, Kun] Chongqing Univ, Three Gorges Hosp, Chongqing Municipal Clin Res Ctr Endocrinol & Meta, Chongqing 404000, Peoples R China.
   [Zhang, Junbei; Meng, Kaikai; Sun, Da; Chen, Xia] Wenzhou Med Univ, Yiwu Cent Hosp, Affiliated Yiwu Hosp, Dept Endocrinol, Yiwu 322000, Peoples R China.
   [Yan, Xiaoqing] Wenzhou Med Univ, Chinese Amer Res Inst Diabetic Complicat, Sch Pharmaceut Sci, Wenzhou 325035, Peoples R China.
   [Yang, Qinsi] Univ Chinese Acad Sci, Wenzhou Inst, Wenzhou 325000, Peoples R China.
   [Zhang, Xingxing] Wenzhou Med Univ, Affiliated Hosp 1, Dept Endocrinol & Metab, Wenzhou 325000, Peoples R China.
C3 Wenzhou University; University of Hong Kong; University of Electronic
   Science & Technology of China; Sichuan Provincial People's Hospital;
   Chongqing University; Wenzhou Medical University; Wenzhou Medical
   University; Chinese Academy of Sciences; University of Chinese Academy
   of Sciences, CAS; Wenzhou Medical University
RP Sun, D (corresponding author), Wenzhou Univ, Inst Life Sci & Biomed, Collaborat Innovat Ctr Zhejiang Prov, Wenzhou 325035, Peoples R China.; Sun, D; Chen, X (corresponding author), Wenzhou Med Univ, Yiwu Cent Hosp, Affiliated Yiwu Hosp, Dept Endocrinol, Yiwu 322000, Peoples R China.
EM sunday@wzu.edu.cn; cxljf2004@wmu.edu.cn
RI Sun, Da/GYE-0903-2022
OI wu, bai hui/0009-0008-9043-5097; xu, pei ye/0009-0003-9266-4794; he, jia
   xuan/0009-0000-8797-4606; Liu, Fan/0000-0001-5120-9048
FU Wenzhou University
FX This work was supported by the Jinhua Municipal Science and Technology
   Bureau Major Science and Technology Plan Project (2024-3-022), the
   National Natural Science Foundation of China (51901160), the Natural
   Science Foundation of Zhejiang Province (LY22H020005), the Chengdu
   Municipal Science and Technology Program (2022-YF05-02018-SN), and the
   Graduate Scientific Research Foundation of Wenzhou University
   (3162024003057, 3162024003056, and 3162024004102).
CR Abdelbasset WK, 2020, CLIN RHEUMATOL, V39, P3091, DOI 10.1007/s10067-020-05086-4
   Agarwal SM, 2021, TRANSL PSYCHIAT, V11, DOI 10.1038/s41398-021-01338-2
   Agirman G, 2021, SCIENCE, V374, P1087, DOI 10.1126/science.abi6087
   Melo MCA, 2016, J AFFECT DISORDERS, V198, P32, DOI 10.1016/j.jad.2016.03.004
   Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   Ansari I, 2020, NAT MICROBIOL, V5, P610, DOI 10.1038/s41564-019-0659-3
   Ashdown-Franks G, 2020, SPORTS MED, V50, P151, DOI 10.1007/s40279-019-01187-6
   Asslih S, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22116138
   Bai WJ, 2022, ZOOL RES, V43, P851, DOI 10.24272/j.issn.2095-8137.2022.122
   Balducci S, 2022, DIABETES CARE, V45, P213, DOI 10.2337/dc21-1505
   Bartova L, 2021, J PSYCHIATR RES, V141, P167, DOI 10.1016/j.jpsychires.2021.06.028
   Bauer ME, 2019, ANN NY ACAD SCI, V1437, P57, DOI 10.1111/nyas.13712
   Baumeister D, 2016, MOL PSYCHIATR, V21, P642, DOI 10.1038/mp.2015.67
   Benatti FB, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.00906
   Bennet H, 2015, PEPTIDES, V71, P113, DOI 10.1016/j.peptides.2015.07.008
   Berge LI, 2015, INT J ENDOCRINOL, V2015, DOI 10.1155/2015/164760
   Beurel E, 2020, NEURON, V107, P234, DOI 10.1016/j.neuron.2020.06.002
   Blaslov K, 2018, MED HYPOTHESES, V114, P8, DOI 10.1016/j.mehy.2018.02.032
   Borovcanin MM, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00271
   Breznoscakova D, 2022, EUR J PSYCHIAT, V36, P152, DOI 10.1016/j.ejpsy.2021.11.002
   Brown WMC, 2015, SPORTS MED-OPEN, V1, DOI 10.1186/s40798-015-0032-x
   Busse M, 2020, PRACT NEUROL, V20, P187, DOI 10.1136/practneurol-2019-002491
   Byrne CJ, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00343
   Cai H, 2017, QUAL LIFE RES, V26, P515, DOI 10.1007/s11136-016-1481-5
   Caliskan H, 2019, BEHAV BRAIN RES, V376, DOI 10.1016/j.bbr.2019.112084
   Calkin CV, 2019, ANN MED, V51, P281, DOI 10.1080/07853890.2019.1659511
   Campbell SC, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0150502
   Cao QQ, 2022, BIOL TRACE ELEM RES, V200, P678, DOI 10.1007/s12011-021-02678-2
   Capuron L, 2011, PHARMACOL THERAPEUT, V130, P226, DOI 10.1016/j.pharmthera.2011.01.014
   Carek PJ, 2011, INT J PSYCHIAT MED, V41, P15, DOI 10.2190/PM.41.1.c
   Chaoul V., 2023, Depression and Anxiety, V2023
   Charles EF, 2016, INT J BIPOLAR DISORD, V4, DOI 10.1186/s40345-016-0054-4
   Chen JB, 2022, SIGNAL TRANSDUCT TAR, V7, DOI 10.1038/s41392-022-01233-2
   Chen M, 2023, NAT COMMUN, V14, DOI 10.1038/s41467-023-44242-7
   Chen SR, 2014, J PSYCHIATR MENT HLT, V21, P414, DOI 10.1111/jpm.12101
   Chen YJ, 2021, NUTRIENTS, V13, DOI 10.3390/nu13062099
   Cheng SL, 2017, J NURS RES, V25, P429, DOI 10.1097/JNR.0000000000000200
   Cimo A, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-24
   Cohen A, 2018, BRIT J GEN PRACT, V68, P166, DOI 10.3399/bjgp18X695381
   Cornelis MC, 2012, ANNU REV NUTR, V32, P245, DOI 10.1146/annurev-nutr-071811-150648
   Cruz NG, 2013, DIABETES RES CLIN PR, V99, P85, DOI 10.1016/j.diabres.2012.09.003
   Cussotto S, 2018, FRONT NEUROENDOCRIN, V51, P80, DOI 10.1016/j.yfrne.2018.04.002
   Dalton A, 2019, GUT MICROBES, V10, P555, DOI 10.1080/19490976.2018.1562268
   Danielsson L, 2014, J AFFECT DISORDERS, V168, P98, DOI 10.1016/j.jad.2014.06.049
   de Groot M, 2019, DIABETES CARE, V42, P1185, DOI 10.2337/dc18-2400
   de Groot M, 2012, CURR DIABETES REP, V12, P157, DOI 10.1007/s11892-012-0261-z
   Hert M, 2012, NAT REV ENDOCRINOL, V8, P114, DOI 10.1038/nrendo.2011.156
   Vallejo-Curto MD, 2021, REV PSIQUIATR SALUD, V14, P125, DOI 10.1016/j.rpsm.2020.11.001
   Dhawan S, 2019, CURR DIABETES REP, V19, DOI 10.1007/s11892-019-1168-8
   Doyenart R, 2024, INT J ENVIRON HEAL R, V34, P826, DOI 10.1080/09603123.2023.2175797
   Dumith Samuel Carvalho, 2019, Rev. bras. epidemiol., V22, pe190023, DOI 10.1590/1980-549720190023
   Dutheil S, 2016, NEUROPSYCHOPHARMACOL, V41, P1874, DOI 10.1038/npp.2015.357
   Duvivier BMFM, 2017, DIABETOLOGIA, V60, P490, DOI 10.1007/s00125-016-4161-7
   Elamoshy R, 2018, J CLIN MED, V7, DOI 10.3390/jcm7110445
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   Fenton A, 2021, J AM PSYCHIAT NURSES, V27, P134, DOI 10.1177/1078390320902825
   Ferris LT, 2007, MED SCI SPORT EXER, V39, P728, DOI 10.1249/mss.0b013e31802f04c7
   Fink A, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0187119
   Firth J, 2015, PSYCHOL MED, V45, P1343, DOI 10.1017/S0033291714003110
   Firth J, 2019, LANCET PSYCHIAT, V6, P675, DOI 10.1016/S2215-0366(19)30132-4
   Firth J, 2017, BRIT J PHARMACOL, V174, P3161, DOI 10.1111/bph.13772
   Fleetwood KJ, 2023, DIABETES CARE, V46, P1363, DOI 10.2337/dc23-0177
   Fletcher GF, 2018, J AM COLL CARDIOL, V72, P1622, DOI 10.1016/j.jacc.2018.08.2141
   Flöel A, 2010, NEUROIMAGE, V49, P2756, DOI 10.1016/j.neuroimage.2009.10.043
   Frederiksen KP, 2021, BEHAV COGN PSYCHOTH, V49, P626, DOI 10.1017/S1352465821000126
   Futch HS, 2019, J EXP MED, V216, P2479, DOI 10.1084/jem.20190430
   Ge TT, 2021, PHARMACOL RES, V173, DOI 10.1016/j.phrs.2021.105909
   Gebeyehu M, 2022, BMC SPORTS SCI MED R, V14, DOI 10.1186/s13102-022-00574-3
   Gilak-Dalasm M, 2021, EXP PHYSIOL, V106, P1981, DOI 10.1113/EP089501
   Gilani SRM, 2019, HEALTH PSYCHOL RES, V7, DOI 10.4081/hpr.2019.6576
   Gilman SE, 2017, CAN MED ASSOC J, V189, pE1304, DOI 10.1503/cmaj.170125
   Giuriato G, 2022, NUTRIENTS, V14, DOI 10.3390/nu14020232
   Goldsmith DR, 2016, MOL PSYCHIATR, V21, P1696, DOI 10.1038/mp.2016.3
   Gopalan V, 2021, BIOSCIENCE REP, V41, DOI 10.1042/BSR20201707
   Gorska-Ciebiada M, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0120433
   Gury-BenAri M, 2016, CELL, V166, P1231, DOI 10.1016/j.cell.2016.07.043
   Hackinger S, 2018, TRANSL PSYCHIAT, V8, DOI 10.1038/s41398-018-0304-6
   Halim M, 2019, DIABETES METAB SYND, V13, P1165, DOI 10.1016/j.dsx.2019.01.040
   Han M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0066299
   Harrison PJ, 2018, TRENDS NEUROSCI, V41, P18, DOI 10.1016/j.tins.2017.10.006
   Hays A., 2007, Doctoral Dissertation.
   He JX, 2023, BIOMED PHARMACOTHER, V168, DOI 10.1016/j.biopha.2023.115807
   Ho RTH, 2016, SCHIZOPHR RES, V171, P42, DOI 10.1016/j.schres.2016.01.038
   Holsen LM, 2013, NEUROSCIENCE, V250, P733, DOI 10.1016/j.neuroscience.2013.07.042
   Holt RIG, 2015, NAT REV ENDOCRINOL, V11, P79, DOI 10.1038/nrendo.2014.203
   Holtzman CW, 2013, NEUROSCIENCE, V249, P172, DOI 10.1016/j.neuroscience.2012.12.017
   Jackson CA, 2019, DIABETES CARE, V42, P1879, DOI 10.2337/dc18-2152
   Jarvie JL, 2019, DIABETES CARE, V42, P1333, DOI 10.2337/dc18-2634
   Jayakody K, 2014, BRIT J SPORT MED, V48, P187, DOI 10.1136/bjsports-2012-091287
   Ji NC, 2018, EXP THER MED, V16, P3511, DOI 10.3892/etm.2018.6597
   Jiang YC, 2019, NEUROIMAGE-CLIN, V24, DOI 10.1016/j.nicl.2019.102081
   Joseph JJ, 2017, ANN NY ACAD SCI, V1391, P20, DOI 10.1111/nyas.13217
   Kale M, 2020, BRAIN RES, V1747, DOI 10.1016/j.brainres.2020.147045
   Kang GG, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21010140
   Kang RY, 2016, PSYCHOPATHOLOGY, V49, P345, DOI 10.1159/000448195
   Kapogiannis D, 2019, EUR PSYCHIAT, V62, P124, DOI 10.1016/j.eurpsy.2019.08.012
   Kato T, 2007, CNS DRUGS, V21, P1, DOI 10.2165/00023210-200721010-00001
   Katon WJ, 2008, AM J MED, V121, P8, DOI 10.1016/j.amjmed.2008.09.008
   Keller-Varady K, 2018, SCHIZOPHR RES, V192, P64, DOI 10.1016/j.schres.2017.06.008
   Kerling A, 2015, J AFFECT DISORDERS, V177, P1, DOI 10.1016/j.jad.2015.01.006
   Khaledi M, 2019, ACTA DIABETOL, V56, P631, DOI 10.1007/s00592-019-01295-9
   Khandaker GM, 2016, PSYCHOPHARMACOLOGY, V233, P1559, DOI 10.1007/s00213-015-3975-1
   Kiecolt-Glaser JK, 2015, AM J PSYCHIAT, V172, P1075, DOI 10.1176/appi.ajp.2015.15020152
   Kieling C, 2011, LANCET, V378, P1515, DOI 10.1016/S0140-6736(11)60827-1
   Kim CJ, 2013, J EXERC REHABIL, V9, P449, DOI 10.12965/jer.130071
   Krishnan V, 2008, NATURE, V455, P894, DOI 10.1038/nature07455
   Krystal JH, 2017, BIOL PSYCHIAT, V82, pE51, DOI 10.1016/j.biopsych.2017.03.007
   Kwok JYY, 2019, JAMA NEUROL, V76, P755, DOI 10.1001/jamaneurol.2019.0534
   Lamers F, 2018, PSYCHOL MED, V48, P1102, DOI 10.1017/S0033291717002483
   Lang XSJ, 2020, BRAIN RES BULL, V165, P30, DOI 10.1016/j.brainresbull.2020.09.015
   Laursen TM, 2012, CURR OPIN PSYCHIATR, V25, P83, DOI 10.1097/YCO.0b013e32835035ca
   Leal LG, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01307
   Li C, 2021, FRONT AGING NEUROSCI, V12, DOI 10.3389/fnagi.2020.615048
   Lin KG, 2019, INT REV NEUROBIOL, V147, P189, DOI 10.1016/bs.irn.2019.07.001
   Lin LL, 2022, DIS MARKERS, V2022, DOI 10.1155/2022/6010504
   Liu Y, 2024, NEUROCHEM RES, V49, P1105, DOI 10.1007/s11064-024-04108-w
   Liu YK, 2022, J AFFECT DISORDERS, V300, P449, DOI 10.1016/j.jad.2021.12.110
   Luo XW, 2023, COMPLEMENT THER CLIN, V50, DOI 10.1016/j.ctcp.2022.101702
   LUSTMAN PJ, 1992, DIABETES CARE, V15, P1631, DOI 10.2337/diacare.15.11.1631
   Maharaj SS, 2023, HEALTH CARE WOMEN IN, V44, P734, DOI 10.1080/07399332.2022.2090566
   Malhi GS, 2015, AUST NZ J PSYCHIAT, V49, P1087, DOI 10.1177/0004867415617657
   Marcellusi A, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2017-018359
   Márkus B, 2022, BMC PRIM CARE, V23, DOI 10.1186/s12875-021-01615-5
   Marquard J, 2015, NAT MED, V21, P363, DOI 10.1038/nm.3822
   Masuda T, 2019, JAMA PSYCHIAT, V76, P1052, DOI 10.1001/jamapsychiatry.2019.1702
   Matinfar P, 2021, PHYSIOL BEHAV, V237, DOI 10.1016/j.physbeh.2021.113449
   Matta J, 2019, J AFFECT DISORDERS, V244, P25, DOI 10.1016/j.jad.2018.09.072
   Maurus I, 2019, EUR ARCH PSY CLIN N, V269, P499, DOI 10.1007/s00406-019-01025-w
   McCoy MA, 2019, Int J Nurs Sci, V6, P468, DOI 10.1016/j.ijnss.2019.09.003
   McGuinness AJ, 2022, MOL PSYCHIATR, V27, P1920, DOI 10.1038/s41380-022-01456-3
   McInerney AM, 2022, DIABETES CARE, V45, P1715, DOI [10.2337/figshare.19692721, 10.2337/dc21-2297]
   McIntyre E, 2019, J AFFECT DISORDERS, V252, P294, DOI 10.1016/j.jad.2019.04.057
   McKibbin CL, 2006, SCHIZOPHR RES, V86, P36, DOI 10.1016/j.schres.2006.05.010
   Mehta BK, 2019, INT J NEUROSCI, V129, P252, DOI 10.1080/00207454.2018.1526795
   Menza M, 2004, J CLIN PSYCHIAT, V65, P471
   Mergenthaler P, 2013, TRENDS NEUROSCI, V36, P587, DOI 10.1016/j.tins.2013.07.001
   Misiak B, 2020, PROG NEURO-PSYCHOPH, V102, DOI 10.1016/j.pnpbp.2020.109951
   Misiak B, 2019, NEUROSCI BIOBEHAV R, V102, P362, DOI 10.1016/j.neubiorev.2019.05.018
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P295, DOI 10.1093/schbul/sbs082
   Mitchell GF, 2011, BRAIN, V134, P3398, DOI 10.1093/brain/awr253
   Mohammadipoor-ghasemabad L., 2018, J. Birjand Univ. Med. Sci., V25, P276
   Monda V, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/3831972
   Myint AM, 2014, PROG NEURO-PSYCHOPH, V48, P304, DOI 10.1016/j.pnpbp.2013.08.008
   Nakanishi K, 2023, NEUROSCI LETT, V808, DOI 10.1016/j.neulet.2023.137297
   Narita Z, 2019, J PSYCHIATR RES, V113, P100, DOI 10.1016/j.jpsychires.2019.03.014
   Ng F, 2007, J AFFECT DISORDERS, V101, P259, DOI 10.1016/j.jad.2006.11.014
   Nigussie K, 2023, BMC PSYCHIATRY, V23, DOI 10.1186/s12888-022-04494-x
   Nikolova VL, 2021, JAMA PSYCHIAT, V78, P1343, DOI 10.1001/jamapsychiatry.2021.2573
   Nindl BC, 2010, MED SCI SPORT EXER, V42, P39, DOI 10.1249/MSS.0b013e3181b07c4d
   Nouwen A, 2010, DIABETOLOGIA, V53, P2480, DOI 10.1007/s00125-010-1874-x
   Nuevo R, 2011, J CLIN PSYCHIAT, V72, P1592, DOI 10.4088/JCP.10m06801
   Oexle N, 2018, EPIDEMIOL PSYCH SCI, V27, P169, DOI 10.1017/S2045796016000949
   Orsolini L, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23031616
   Orumiyehei A, 2022, BRAIN SCI, V12, DOI 10.3390/brainsci12101280
   Ottosson F, 2018, J CLIN ENDOCR METAB, V103, P3060, DOI 10.1210/jc.2018-00546
   Ozougwu O. K. C., 2013, Acad J, V4, P46, DOI [DOI 10.5897/JPAP2013.0001, 10.5897/jpap2013.0001]
   Pan WH, 1998, NEUROPHARMACOLOGY, V37, P1553, DOI 10.1016/S0028-3908(98)00141-5
   Papiol S, 2019, TRANSL PSYCHIAT, V9, DOI 10.1038/s41398-019-0618-z
   Pareja-Galeano H, 2013, J MUSCULOSKEL NEURON, V13, P368
   Pariante CM, 2017, EUR NEUROPSYCHOPHARM, V27, P554, DOI 10.1016/j.euroneuro.2017.04.001
   Patel H, 2017, WORLD J CARDIOL, V9, P134, DOI 10.4330/wjc.v9.i2.134
   Pedersen BK, 2015, SCAND J MED SCI SPOR, V25, P1, DOI 10.1111/sms.12581
   Pedersen BK, 2006, ESSAYS BIOCHEM, V42, P105, DOI 10.1042/bse0420105
   Penckofer SM, 2012, ANN BEHAV MED, V44, P192, DOI 10.1007/s12160-012-9377-2
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Pinquart M, 2010, PSYCHOL MED, V40, P1797, DOI 10.1017/S0033291709992285
   Pinti MV, 2019, AM J PHYSIOL-ENDOC M, V316, pE268, DOI 10.1152/ajpendo.00314.2018
   Pott GB, 2009, J LEUKOCYTE BIOL, V85, P886, DOI 10.1189/jlb.0208145
   Prieto ML, 2014, ACTA PSYCHIAT SCAND, V130, P342, DOI 10.1111/acps.12293
   Qiu D, 2023, EXP GERONTOL, V182, DOI 10.1016/j.exger.2023.112293
   Rammal H, 2008, BRAIN BEHAV IMMUN, V22, P1156, DOI 10.1016/j.bbi.2008.06.005
   Regenold WT, 2002, J AFFECT DISORDERS, V70, P19, DOI 10.1016/S0165-0327(01)00456-6
   Rodríguez-Ramírez AM, 2023, NEUROPSYCH DIS TREAT, V19, P197, DOI 10.2147/NDT.S392672
   Rom S, 2019, MOL NEUROBIOL, V56, P1883, DOI 10.1007/s12035-018-1195-5
   Rosenblat JD, 2015, ACTA PSYCHIAT SCAND, V132, P180, DOI 10.1111/acps.12414
   Rosenblat JD, 2015, J AFFECT DISORDERS, V188, P149, DOI 10.1016/j.jad.2015.08.058
   Roy T, 2012, J AFFECT DISORDERS, V142, pS8, DOI 10.1016/S0165-0327(12)70004-6
   Ruiz-Casado A, 2017, TRENDS CANCER, V3, P423, DOI 10.1016/j.trecan.2017.04.007
   Safren SA, 2014, DIABETES CARE, V37, P625, DOI [10.2337/dc13-0816, 10.2337/dc16-er06]
   Salvi V, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0182088
   Santana-Martínez RA, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8090388
   Sardar Mohammad Ali, 2014, Glob J Health Sci, V6, P196, DOI 10.5539/gjhs.v6n2p196
   Sarkar P, 2021, J MOL NEUROSCI, V71, P2608, DOI 10.1007/s12031-021-01875-x
   Sasaninezhad M, 2024, GERIATR NURS, V56, P32, DOI 10.1016/j.gerinurse.2023.12.008
   Schäbitz WR, 2007, TRENDS PHARMACOL SCI, V28, P157, DOI 10.1016/j.tips.2007.02.007
   Schneider KL, 2016, BEHAV THER, V47, P198, DOI 10.1016/j.beth.2015.10.005
   Schroeder RL, 2016, EXPERT OPIN THER PAT, V26, P139, DOI 10.1517/13543776.2016.1105217
   Schuch FB, 2015, PSYCHIAT RES, V229, P57, DOI 10.1016/j.psychres.2015.07.072
   Semenkovich K, 2015, DRUGS, V75, P577, DOI 10.1007/s40265-015-0347-4
   Shellington EM, 2018, METAB SYNDR RELAT D, V16, P255, DOI 10.1089/met.2018.0021
   Silva RA, 2010, EUR RESPIR J, V35, P994, DOI 10.1183/09031936.00049509
   Simayi A, 2019, ENDOCR J, V66, P793, DOI 10.1507/endocrj.EJ18-0579
   Singh VP, 2020, INT J YOGA, V13, P144, DOI 10.4103/ijoy.IJOY_45_19
   Slyepchenko A, 2016, CURR PHARM DESIGN, V22, P6087, DOI 10.2174/1381612822666160922165706
   Smith KJ, 2013, J PSYCHOSOM RES, V74, P89, DOI 10.1016/j.jpsychores.2012.11.013
   Socala K, 2021, PHARMACOL RES, V172, DOI 10.1016/j.phrs.2021.105840
   Sohrabipour S, 2018, EUR J PHARMACOL, V826, P75, DOI 10.1016/j.ejphar.2018.01.047
   Solvsten CAE, 2018, MOL NEUROBIOL, V55, P567, DOI 10.1007/s12035-016-0344-y
   Steardo L Jr, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00501
   Steen NE, 2014, J PSYCHIATR RES, V52, P57, DOI 10.1016/j.jpsychires.2014.01.017
   Steffenhagen N, 2012, NERVENARZT, V83, P337, DOI 10.1007/s00115-010-3207-1
   Stellmann JP, 2020, FRONT HUM NEUROSCI, V14, DOI 10.3389/fnhum.2020.00255
   Steullet P, 2016, SCHIZOPHR RES, V176, P41, DOI 10.1016/j.schres.2014.06.021
   Stuart MJ, 2012, NEUROSCI BIOBEHAV R, V36, P658, DOI 10.1016/j.neubiorev.2011.10.001
   Stubbs B, 2018, EUR PSYCHIAT, V54, P124, DOI 10.1016/j.eurpsy.2018.07.004
   Stubbs B, 2017, PSYCHIAT RES, V249, P102, DOI 10.1016/j.psychres.2016.12.020
   Subba R, 2021, EUR J NEUROSCI, V53, P2870, DOI 10.1111/ejn.15136
   Sudo N, 2004, INT ARCH ALLERGY IMM, V135, P132, DOI 10.1159/000080655
   Sudo N, 2012, CHEM IMMUNOL ALLERGY, V98, P163, DOI 10.1159/000336510
   Sumlin LL, 2014, DIABETES EDUCATOR, V40, P731, DOI 10.1177/0145721714538925
   Sun H, 2023, DIABETES RES CLIN PR, V204, DOI 10.1016/j.diabres.2023.110945
   Sun LN, 2018, BRAIN RES, V1697, P1, DOI 10.1016/j.brainres.2018.04.040
   Szulc-Lerch KU, 2018, NEUROIMAGE-CLIN, V18, P972, DOI 10.1016/j.nicl.2018.02.021
   Takeishi J, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222212310
   Tao HR, 2023, EUR J CLIN INVEST, V53, DOI 10.1111/eci.13893
   Teixeira AL, 2019, EXPERT REV NEUROTHER, V19, P67, DOI 10.1080/14737175.2019.1550361
   Thoe ES, 2021, LIFE SCI, V276, DOI 10.1016/j.lfs.2021.119129
   Tian JD, 2013, DIABETES, V62, P3760, DOI 10.2337/db13-0931
   Vallee A, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23052810
   Vancampfort D, 2014, PSYCHIAT RES, V220, P58, DOI 10.1016/j.psychres.2014.06.008
   Vaynman S, 2006, J NEUROSCI RES, V84, P699, DOI 10.1002/jnr.20979
   Villas-Boas GR, 2021, PHARMACEUTICALS-BASE, V14, DOI 10.3390/ph14020148
   Vlachou E, 2022, J DIABETES COMPLICAT, V36, DOI 10.1016/j.jdiacomp.2022.108185
   Wang L, 2022, LIFE SCI, V300, DOI 10.1016/j.lfs.2022.120578
   Wang MZ, 2023, MOL MED, V29, DOI 10.1186/s10020-023-00727-1
   Wang YH, 2023, MOL BIOMED, V4, DOI 10.1186/s43556-023-00154-y
   Wegner M, 2014, CNS NEUROL DISORD-DR, V13, P1002, DOI 10.2174/1871527313666140612102841
   Weng YT, 2018, J BIOMED SCI, V25, DOI 10.1186/s12929-018-0473-x
   Wu PL, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0181515
   Zang YN, 2023, MEDIAT INFLAMM, V2023, DOI 10.1155/2023/5127157
   Zhang Y, 2022, BRAIN RES BULL, V181, P12, DOI 10.1016/j.brainresbull.2022.01.007
   Zhou CL, 2019, NEUROGASTROENT MOTIL, V31, DOI 10.1111/nmo.13461
   Zhou XY, 2018, METAB BRAIN DIS, V33, P705, DOI 10.1007/s11011-017-0179-x
   Zhu XJ, 2019, PROG NEURO-PSYCHOPH, V93, P141, DOI 10.1016/j.pnpbp.2019.03.020
NR 234
TC 0
Z9 0
U1 9
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1091-4269
EI 1520-6394
J9 DEPRESS ANXIETY
JI Depress. Anxiety
PY 2024
VL 2024
IS 1
AR 6651804
DI 10.1155/da/6651804
PG 31
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA Q7D8G
UT WOS:001386247000001
PM 40226688
OA hybrid
DA 2025-06-11
ER

PT J
AU Stalder, T
   Steudte-Schmiedgen, S
   Alexander, N
   Klucken, T
   Vater, A
   Wichmann, S
   Kirschbaum, C
   Miller, R
AF Stalder, Tobias
   Steudte-Schmiedgen, Susann
   Alexander, Nina
   Klucken, Tim
   Vater, Annika
   Wichmann, Susann
   Kirschbaum, Clemens
   Miller, Robert
TI Stress-related and basic determinants of hair cortisol in humans: A
   meta-analysis
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE Hair cortisol; Meta-analysis; Stress; Confounder; Validity
ID LONG-TERM CORTISOL; AWAKENING RESPONSE; SCALP HAIR; METABOLIC SYNDROME;
   MAJOR DEPRESSION; HPA AXIS; TRAUMA EXPOSURE; MENTAL-HEALTH; BIOMARKER;
   DISORDER
AB The analysis of hair cortisol concentrations (HCC) is a relatively new strategy to measure long-term cumulative cortisol levels, which is increasingly used in psychoneuroendocrinological research. Here, we conduct a first comprehensive meta-analysis of HCC research based on aggregated data from a total of 124 (sub)samples (66 independent studies; total N = 10,289). We seek to answer two central questions: (i) Which covariates and basic features of HCC need to be considered in future research? (ii) What are the main determinants of HCC in terms of chronic stress exposure and mental health? Concerning basic characteristics, our findings identify several covariates to be considered (age, sex, hair washing frequency, hair treatment, oral contraceptive use), confirm a decline of HCC from the first to the second proximal 3 cm hair segment, and show positive associations between HCC and short-term salivary cortisol measures. Regarding chronic stress, we show that stress-exposed groups on a whole exhibit 22% increased HCC. This long-term cortisol hypersecretion emerges particularly when stress is still ongoing at the time of study (+43% HCC) but is not present in conditions of past/absent stress (-9% HCC, n.s.). We also report evidence for 17%-reduced HCC in anxiety disorders, such as PTSD. Interestingly, no consistent associations with mood disorders and self-reports of perceived stress, depressiveness or social support are found. However, our findings reveal positive associations of HCC with stress-related anthropometric (body mass index, waist-to-hip ratio) and hemodynamic measures (systolic blood pressure). These meta-analytic results are discussed in the light of their practical implications and important areas for future inquiry are outlined. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Stalder, Tobias; Steudte-Schmiedgen, Susann; Alexander, Nina; Vater, Annika; Wichmann, Susann; Kirschbaum, Clemens; Miller, Robert] Tech Univ Dresden, Biol Psychol, Dresden, Germany.
   [Stalder, Tobias; Klucken, Tim] Univ Siegen, Clin Psychol, Adolf Reichwein Str 2a, D-57076 Siegen, Germany.
   [Alexander, Nina] Med Sch Hamburg, Differential & Personal Psychol, Hamburg, Germany.
   [Miller, Robert] Med Sch Berlin, Fac Nat Sci, Berlin, Germany.
C3 Technische Universitat Dresden; Universitat Siegen; MSH Medical School
   Hamburg
RP Stalder, T (corresponding author), Univ Siegen, Clin Psychol, Adolf Reichwein Str 2a, D-57076 Siegen, Germany.
EM tobias.stalder@psychologie.uni-siegen.de
RI Kirschbaum, Clemens/AAB-1752-2020; Miller, Robert/G-4473-2016;
   /HHZ-4248-2022; Klucken, Tim/F-7669-2013
OI Miller, Robert/0000-0002-8665-5248; Alexander, Nina/0009-0002-7412-0163;
   /0000-0002-1171-7133; Stalder, Tobias/0000-0001-7558-1274; Klucken,
   Tim/0000-0003-2433-6652
FU German Research Foundation (DFG) [STA 1213/5-1, SFB 940/2]
FX Susann Steudte-Schmiedgen was supported by the German Research
   Foundation (DFG; STA 1213/5-1). Robert Miller was supported by the
   German Research Foundation (DFG, SFB 940/2).
CR Aguinis H, 2001, PERS PSYCHOL, V54, P569, DOI 10.1111/j.1744-6570.2001.tb00223.x
   Almeida DM, 2009, PSYCHOL AGING, V24, P819, DOI 10.1037/a0017910
   [Anonymous], BIOL PSYCHOL
   [Anonymous], NEUROSCI BIOBEHAV RE
   [Anonymous], NEURON
   [Anonymous], J CLIN ENDOCRINOL ME
   [Anonymous], J STEROID BIOCH MOL
   [Anonymous], PLOS ONE
   [Anonymous], PSYCHONEUROENDOCRINO
   [Anonymous], CLIN INVESTIG MED
   [Anonymous], BECK DEPRESSIONS INV
   [Anonymous], 2015, PLOS ONE
   [Anonymous], CARDIOVASC PSYCHIAT
   BEGG CB, 1994, BIOMETRICS, V50, P1088, DOI 10.2307/2533446
   BERNARD HR, 1984, ANNU REV ANTHROPOL, V13, P495, DOI 10.1146/annurev.an.13.100184.002431
   Boesch M, 2015, STRESS, V18, P35, DOI 10.3109/10253890.2014.974028
   Borenstein M, 2009, Introduction to meta-analysis, P421
   Braig S, 2015, PSYCHONEUROENDOCRINO, V52, P289, DOI 10.1016/j.psyneuen.2014.12.006
   Campbell J, 2012, PSYCHONEUROENDOCRINO, V37, P1111, DOI 10.1016/j.psyneuen.2011.12.010
   Chan J, 2014, EXP CLIN ENDOCR DIAB, V122, P356, DOI 10.1055/s-0034-1374609
   Chen XL, 2015, BMC PEDIATR, V15, DOI 10.1186/s12887-015-0322-y
   Chen Z, 2014, J CHROMATOGR B, V969, P77, DOI 10.1016/j.jchromb.2014.08.001
   Chen Z, 2013, J CHROMATOGR B, V929, P187, DOI 10.1016/j.jchromb.2013.04.026
   Chida Y, 2009, BIOL PSYCHOL, V80, P265, DOI 10.1016/j.biopsycho.2008.10.004
   Chrousos GP, 2009, NAT REV ENDOCRINOL, V5, P374, DOI 10.1038/nrendo.2009.106
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   CONNELL JMC, 1987, J HYPERTENS, V5, P425
   COSTE J, 1994, BRIT J CLIN PHARMACO, V38, P474, DOI 10.1111/j.1365-2125.1994.tb04386.x
   CSIKSZENTMIHALYI M, 1987, J NERV MENT DIS, V175, P526, DOI 10.1097/00005053-198709000-00004
   D'Anna-Hernandez KL, 2011, PHYSIOL BEHAV, V104, P348, DOI 10.1016/j.physbeh.2011.02.041
   Dettenborn L, 2010, PSYCHONEUROENDOCRINO, V35, P1404, DOI 10.1016/j.psyneuen.2010.04.006
   Dettenborn L, 2012, STRESS, V15, P348, DOI 10.3109/10253890.2011.619239
   Dickerson SS, 2004, PSYCHOL BULL, V130, P355, DOI 10.1037/0033-2909.130.3.355
   Dowlati Y, 2010, NEUROPSYCH DIS TREAT, V6, P393
   Etwel F, 2014, CLIN INVEST MED, V37, pE403
   Feldman PJ, 1999, ANN BEHAV MED, V21, P216, DOI 10.1007/BF02884836
   Feller S, 2014, PSYCHONEUROENDOCRINO, V39, P132, DOI 10.1016/j.psyneuen.2013.10.007
   GALBO H, 1981, INT J SPORTS MED, V2, P203, DOI 10.1055/s-2008-1034610
   Gao W, 2014, PSYCHOPHYSIOLOGY, V51, P319, DOI 10.1111/psyp.12179
   Gao W, 2010, CLIN BIOCHEM, V43, P677, DOI 10.1016/j.clinbiochem.2010.01.014
   Gerber M, 2013, STRESS, V16, P593, DOI 10.3109/10253890.2013.823599
   Gerber M, 2013, NEUROPSYCHOBIOLOGY, V68, P100, DOI 10.1159/000351735
   Gibson EL, 1999, PSYCHOSOM MED, V61, P214, DOI 10.1097/00006842-199903000-00014
   Glover DA, 2002, PSYCHONEUROENDOCRINO, V27, P805, DOI 10.1016/S0306-4530(01)00081-6
   Goldberg SB, 2014, J ALTERN COMPLEM MED, V20, P630, DOI 10.1089/acm.2014.0080
   Gow R, 2011, CLIN ENDOCRINOL, V74, P687, DOI 10.1111/j.1365-2265.2011.04001.x
   Grass J, 2015, PSYCHONEUROENDOCRINO, V53, P108, DOI 10.1016/j.psyneuen.2014.12.023
   Grassi-Oliveira R, 2012, AM J DRUG ALCOHOL AB, V38, P535, DOI 10.3109/00952990.2012.694538
   HARRIS T, 1991, Annals of Behavioral Medicine, V13, P211
   Heim C, 2008, PSYCHONEUROENDOCRINO, V33, P693, DOI 10.1016/j.psyneuen.2008.03.008
   Hellhammer J, 2007, PSYCHONEUROENDOCRINO, V32, P80, DOI 10.1016/j.psyneuen.2006.10.005
   Heuser I, 2003, NEUROBIOL AGING, V24, pS69, DOI 10.1016/S0197-4580(03)00048-4
   Hinkelmann K, 2013, BIOL PSYCHIAT, V74, pE15, DOI 10.1016/j.biopsych.2013.04.021
   Kalra S, 2007, CLIN INVEST MED, V30, pE103, DOI 10.25011/cim.v30i2.986
   Karatsoreos IN, 2010, ENDOCRINOLOGY, V151, P2117, DOI 10.1210/en.2009-1436
   Karlén J, 2015, PEDIATRICS, V135, pE1450, DOI 10.1542/peds.2014-2561
   Karlén J, 2011, BMC CLIN PATHOL, V11, DOI 10.1186/1472-6890-11-12
   Kelly JJ, 1998, CLIN EXP PHARMACOL P, V25, pS51, DOI 10.1111/j.1440-1681.1998.tb02301.x
   KIRSCHBAUM C, 1990, PSYCHONEUROENDOCRINO, V15, P297, DOI 10.1016/0306-4530(90)90080-S
   Kirschbaum C, 2009, PSYCHONEUROENDOCRINO, V34, P32, DOI 10.1016/j.psyneuen.2008.08.024
   Knapp G, 2003, STAT MED, V22, P2693, DOI 10.1002/sim.1482
   Kozik P, 2015, GERONTOLOGY, V61, P166, DOI 10.1159/000368716
   Kudielka BM, 2009, PSYCHONEUROENDOCRINO, V34, P2, DOI 10.1016/j.psyneuen.2008.10.004
   Kuehl LK, 2015, PSYCHONEUROENDOCRINO, V51, P365, DOI 10.1016/j.psyneuen.2014.09.012
   Lambert Cynthia A, 2013, J Dent Hyg, V87, P73
   Langerak T, 2015, CLIN ENDOCRINOL, V83, P167, DOI 10.1111/cen.12790
   Larsson CA, 2009, BMC ENDOCR DISORD, V9, DOI 10.1186/1472-6823-9-16
   Laughlin GA, 2000, J CLIN ENDOCR METAB, V85, P3561, DOI 10.1210/jc.85.10.3561
   Manenschijn L, 2013, J CLIN ENDOCR METAB, V98, P2078, DOI 10.1210/jc.2012-3663
   Manenschijn L, 2012, EUR J CLIN MICROBIOL, V31, P97, DOI 10.1007/s10096-011-1282-2
   Manenschijn L, 2012, PSYCHONEUROENDOCRINO, V37, P1960, DOI 10.1016/j.psyneuen.2012.04.010
   Manenschijn L, 2011, J CLIN ENDOCR METAB, V96, pE1862, DOI 10.1210/jc.2011-1551
   Manenschijn L, 2011, STEROIDS, V76, P1032, DOI 10.1016/j.steroids.2011.04.005
   Mauss IB, 2005, EMOTION, V5, P175, DOI 10.1037/1528-3542.5.2.175
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   Meewisse ML, 2007, BRIT J PSYCHIAT, V191, P387, DOI 10.1192/bjp.bp.106.024877
   MENDELSON JH, 1966, PSYCHOSOM MED, V28, P616, DOI 10.1097/00006842-196607000-00037
   Menning S, 2015, NEUROIMAGE-CLIN, V7, P547, DOI 10.1016/j.nicl.2015.02.005
   Meyer JS, 2012, ENDOCRINOLOGY, V153, P4120, DOI 10.1210/en.2012-1226
   Miller GE, 2007, PSYCHOL BULL, V133, P25, DOI 10.1037/0033-2909.133.1.25
   Miller R, 2013, PSYCHONEUROENDOCRINO, V38, P941, DOI 10.1016/j.psyneuen.2012.09.013
   Morris MC, 2012, CLIN PSYCHOL REV, V32, P301, DOI 10.1016/j.cpr.2012.02.002
   Morris SB, 2002, PSYCHOL METHODS, V7, P105, DOI 10.1037//1082-989X.7.1.105
   Nakagawa S, 2012, EVOL ECOL, V26, P1253, DOI 10.1007/s10682-012-9555-5
   O'Brien KM, 2013, STRESS HEALTH, V29, P337, DOI 10.1002/smi.2475
   Ouellette SJ, 2015, DEV PSYCHOBIOL, V57, P519, DOI 10.1002/dev.21302
   Pariante CM, 2008, TRENDS NEUROSCI, V31, P464, DOI 10.1016/j.tins.2008.06.006
   Peters JL, 2008, J CLIN EPIDEMIOL, V61, P991, DOI 10.1016/j.jclinepi.2007.11.010
   Pulopulos MM, 2014, PSYCHONEUROENDOCRINO, V44, P100, DOI 10.1016/j.psyneuen.2014.03.002
   Qi XL, 2015, INT ARCH OCC ENV HEA, V88, P1053, DOI 10.1007/s00420-015-1033-2
   Qi XL, 2014, J PSYCHOSOM RES, V76, P329, DOI 10.1016/j.jpsychores.2014.01.008
   R Core Team, 2015, R: a language and environment for statistical computing
   Raul JS, 2004, CLIN BIOCHEM, V37, P1105, DOI 10.1016/j.clinbiochem.2004.02.010
   REBUFFESCRIVE M, 1992, PHYSIOL BEHAV, V52, P583, DOI 10.1016/0031-9384(92)90351-2
   Remer T, 2008, MINI-REV MED CHEM, V8, P153, DOI 10.2174/138955708783498096
   Rohleder N, 2004, BIOL PSYCHIAT, V55, P745, DOI 10.1016/j.biopsych.2003.11.018
   Russell E, 2015, THER DRUG MONIT, V37, P71, DOI 10.1097/FTD.0000000000000148
   Russell E, 2012, PSYCHONEUROENDOCRINO, V37, P589, DOI 10.1016/j.psyneuen.2011.09.009
   Sapolsky RM, 2000, ENDOCR REV, V21, P55, DOI 10.1210/er.21.1.55
   Sauve B, 2007, CLIN INVEST MED, V30, pE183, DOI 10.25011/cim.v30i5.2894
   Schulz P, 1999, DIAGNOSTICA, V45, P8, DOI 10.1026//0012-1924.45.1.8
   Skoluda N, 2012, PSYCHONEUROENDOCRINO, V37, P611, DOI 10.1016/j.psyneuen.2011.09.001
   Spaderna H, 2009, APPL PSYCHOL-HLTH WE, V1, P188, DOI 10.1111/j.1758-0854.2008.01006.x
   Spiga F, 2014, COMPR PHYSIOL, V4, P1273, DOI 10.1002/cphy.c140003
   Stalder T, 2016, PSYCHONEUROENDOCRINO, V63, P414, DOI 10.1016/j.psyneuen.2015.10.010
   Stalder T, 2014, PSYCHONEUROENDOCRINO, V47, P26, DOI 10.1016/j.psyneuen.2014.04.021
   Stalder T, 2013, J CLIN ENDOCR METAB, V98, P2573, DOI 10.1210/jc.2013-1056
   Stalder T, 2012, BRAIN BEHAV IMMUN, V26, P1019, DOI 10.1016/j.bbi.2012.02.002
   Stalder T, 2012, BIOL PSYCHOL, V90, P218, DOI 10.1016/j.biopsycho.2012.03.010
   Stalder T, 2012, PSYCHONEUROENDOCRINO, V37, P602, DOI 10.1016/j.psyneuen.2011.08.007
   Stalder T, 2010, BIOL PSYCHOL, V85, P357, DOI 10.1016/j.biopsycho.2010.08.005
   Stalder T, 2011, PSYCHONEUROENDOCRINO, V36, P454, DOI [10.1016/j.psyneuen.2010.07.020, 10.1016/j.psyneuen.2010.02.014]
   Staufenbiel SM, 2015, PSYCHONEUROENDOCRINO, V60, P182, DOI 10.1016/j.psyneuen.2015.06.011
   Staufenbiel SM, 2014, STRESS, V17, P451, DOI 10.3109/10253890.2014.968549
   Staufenbiel SM, 2013, PSYCHONEUROENDOCRINO, V38, P1220, DOI 10.1016/j.psyneuen.2012.11.015
   Steinisch M, 2014, PSYCHONEUROENDOCRINO, V50, P20, DOI 10.1016/j.psyneuen.2014.08.001
   Steptoe A, 2006, INT J PSYCHOPHYSIOL, V59, P228, DOI 10.1016/j.ijpsycho.2005.10.011
   Steudte S, 2013, BIOL PSYCHIAT, V74, P639, DOI 10.1016/j.biopsych.2013.03.011
   Steudte S, 2011, PSYCHONEUROENDOCRINO, V36, P1193, DOI 10.1016/j.psyneuen.2011.02.012
   Steudte S, 2011, PSYCHIAT RES, V186, P310, DOI 10.1016/j.psychres.2010.09.002
   Steudte-Schmiedgen S, 2016, NEUROSCI BIOBEHAV R, V69, P124, DOI 10.1016/j.neubiorev.2016.07.015
   Steudte-Schmiedgen S, 2015, PSYCHONEUROENDOCRINO, V59, P123, DOI 10.1016/j.psyneuen.2015.05.007
   Steudte-Schmiedgen S, 2014, COGN AFFECT BEHAV NE, V14, P1310, DOI 10.3758/s13415-014-0299-2
   Stone Arthur S., 1994, Annals of Behavioral Medicine, V16, P199
   Sumra MK, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0120952
   Tafet GE., 2015, The Journal of neuropsychiatry and clinical neurosciences:appineuropsych15030053
   Thomson S, 2010, EXP CLIN ENDOCR DIAB, V118, P133, DOI 10.1055/s-0029-1220771
   Thomson S, 2009, THER DRUG MONIT, V31, P779, DOI 10.1097/FTD.0b013e3181c004f1
   Vaghri Z, 2013, PSYCHONEUROENDOCRINO, V38, P331, DOI 10.1016/j.psyneuen.2012.06.009
   van Holland BJ, 2012, INT ARCH OCC ENV HEA, V85, P849, DOI 10.1007/s00420-011-0727-3
   van Ockenburg SL, 2016, PSYCHONEUROENDOCRINO, V73, P142, DOI 10.1016/j.psyneuen.2016.07.220
   Van Sonderen F. I.. P., 1993, METEN SOCIALE STEUN
   Van Uum SHM, 2008, STRESS, V11, P483, DOI 10.1080/10253890801887388
   Vanaelst B, 2013, EUR J PEDIATR, V172, P843, DOI 10.1007/s00431-013-1955-1
   Vanaelst B, 2012, PSYCHOPHYSIOLOGY, V49, P1072, DOI 10.1111/j.1469-8986.2012.01396.x
   VanCauter E, 1996, J CLIN ENDOCR METAB, V81, P2468, DOI 10.1210/jc.81.7.2468
   Veldhorst MAB, 2014, J CLIN ENDOCR METAB, V99, P285, DOI 10.1210/jc.2013-2924
   Viechtbauer W, 2010, J STAT SOFTW, V36, P1, DOI 10.18637/jss.v036.i03
   Walton DM, 2013, PAIN RES TREAT, V2013, DOI 10.1155/2013/876871
   Wei JX, 2015, J AFFECT DISORDERS, V175, P299, DOI 10.1016/j.jad.2015.01.023
   Wells S, 2014, STRESS, V17, P334, DOI 10.3109/10253890.2014.930432
   Wessa M, 2006, PSYCHONEUROENDOCRINO, V31, P209, DOI 10.1016/j.psyneuen.2005.06.010
   Wester VL, 2014, OBESITY, V22, P1956, DOI 10.1002/oby.20795
   Wingenfeid K, 2015, PSYCHONEUROENDOCRINO, V52, P83, DOI 10.1016/j.psyneuen.2014.10.023
   Wosu AC, 2015, ANN EPIDEMIOL, V25, P90, DOI 10.1016/j.annepidem.2014.11.022
   Wosu AC, 2013, ANN EPIDEMIOL, V23, P797, DOI 10.1016/j.annepidem.2013.09.006
   Wright KD, 2015, GERONTOLOGIST, V55, pS140, DOI 10.1093/geront/gnu174
   Xie QZ, 2011, CLIN CHEM LAB MED, V49, P2013, DOI 10.1515/CCLM.2011.706
   Yehuda R, 1996, BIOL PSYCHIAT, V40, P79, DOI 10.1016/0006-3223(95)00451-3
   Younge JO, 2015, INT J CARDIOL, V184, P71, DOI 10.1016/j.ijcard.2015.02.005
NR 150
TC 635
Z9 677
U1 8
U2 216
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAR
PY 2017
VL 77
BP 261
EP 274
DI 10.1016/j.psyneuen.2016.12.017
PG 14
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA EP4UJ
UT WOS:000397375100034
PM 28135674
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Ming, Z
   Legare, DJ
   Lautt, WW
AF Ming, Zhi
   Legare, Dallas J.
   Lautt, W. Wayne
TI Obesity, syndrome X, and diabetes: the role of HISS-dependent insulin
   resistance altered by sucrose, an antioxidant cocktail, and age
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE HOMA; nutrition; insulin sensitivity; HISS; postprandial; meal;
   metabolic syndrome; cardiometabolic risk; age
ID SENSITIVITY; SENSITIZATION; MEAL; RATS
AB Absence of meal-induced insulin sensitization (AMIS) results in a predictable progression of dysfunctions, including postprandial hyperglycemia, compensatory hyperinsulinemia, resultant hyperlipidemia, increased oxidative stress, and obesity, progressing to syndrome X and diabetes. To test the 'AMIS syndrome' hypothesis we used 3 known means of producing graded and progressive changes in meal-induced insulin sensitization in rats. We used an aging model (9. 26, and 52 weeks), associated with a slow development of AMIS a low-dose Sucrose supplement model to accelerate the development of AMIS; and an antioxidant cocktail (S-adenosylmethionine, vitamin E, and vitamin Q to protect against the effect of the sucrose oil meal-induced insulin sensitization. Adiposity was assessed from weighed regional fat masses and bioelectrical impedance. AMIS developed with age, was increased by Sucrose Supplementation, and was inhibited by the antioxidant cocktail. AMIS correlated With postprandial hyperglycemia, hyperinsulinemia. hyperlipidemia, and with adiposity (r(2) = 0.7-0.8) regardless of age or nutrient status. The range of degrees of AMIS. established over time with these models, afforded the tool with which to test the AMIS syndrome and further the argument that AMIS is the First metabolic defect that cumulatively leads to a predictable series of homeostatic disturbances and dysfunctions, including obesity and type 2 diabetes.
C1 [Ming, Zhi; Legare, Dallas J.; Lautt, W. Wayne] Univ Manitoba, Fac Med, Dept Pharmacol & Therapeut, Winnipeg, MB R3E 0T6, Canada.
C3 University of Manitoba
RP Lautt, WW (corresponding author), Univ Manitoba, Fac Med, Dept Pharmacol & Therapeut, 753 McDermot Ave, Winnipeg, MB R3E 0T6, Canada.
EM wlautt@cc.umanitoba.ca
RI Legare, Dallas/AAC-3234-2021; Lautt, W./AAC-6106-2021
OI Lautt, W. Wayne/0000-0002-7239-1798
FU Canadian Institutes of Health Research [FRN-82037, FRN84533]; Manitoba
   Health Research Council Regional C; Partnership Program; Canadian Liver
   Foundation; Canadian Diabetes Association
FX This study was funded by operating grants from the Canadian Institutes
   of Health Research (FRN-82037 and FRN84533) and the Manitoba Health
   Research Council Regional C; Partnership Program, the Canadian Liver
   Foundation, and the Canadian Diabetes Association. Manuscript
   preparation was by Karen Sanders. We acknowledge the excellent daily and
   long-term care and monitoring of the animals provided by Gerry Nolette
   and the staff of Central Animal Care Services at the University of
   Manitoba. Related interests: W.W. Lautt and Z. Ming have a patent
   pending on the antioxidant cocktail.
CR HALL CB, 1989, NUTR REP INT, V39, P627
   Lautt WW, 2008, EXP GERONTOL, V43, P790, DOI 10.1016/j.exger.2008.04.013
   Lautt W Wayne, 2007, Ther Clin Risk Manag, V3, P761
   Lautt WW, 1999, CAN J PHYSIOL PHARM, V77, P553, DOI 10.1139/cjpp-77-8-553
   Lautt WW, 1998, CAN J PHYSIOL PHARM, V76, P1080, DOI 10.1139/cjpp-76-12-1080
   Lautt WW, 2004, J PHARMACOL SCI, V95, P9, DOI 10.1254/jphs.95.9
   Lautt WW, 2003, MED RES REV, V23, P1, DOI 10.1002/med.10022
   Lautt WW, 2001, AM J PHYSIOL-GASTR L, V281, pG29, DOI 10.1152/ajpgi.2001.281.1.G29
   LAUTT WW, 1998, FALK S, V103, P1
   Ming Z, 2006, FREE RADICAL BIO MED, V40, P617, DOI 10.1016/j.freeradbiomed.2005.09.034
   Moore MC, 2002, AM J PHYSIOL-ENDOC M, V282, pE286, DOI 10.1152/ajpendo.00201.2001
   Patarrao Rita S, 2007, Proc West Pharmacol Soc, V50, P105
   Patarrao RS, 2008, CAN J PHYSIOL PHARM, V86, P880, DOI 10.1139/Y08-080
   Petersen KF, 2007, P NATL ACAD SCI USA, V104, P12587, DOI 10.1073/pnas.0705408104
   Ribeiro R, 2005, DIABETOLOGIA, V48, P976, DOI 10.1007/s00125-005-1714-6
   Ribeiro RT, 2008, J GERONTOL A-BIOL, V63, P560, DOI 10.1093/gerona/63.6.560
   Sadri P, 2006, BRIT J NUTR, V95, P288, DOI 10.1079/BJN20051644
   Wallace TM, 2004, DIABETES CARE, V27, P1487, DOI 10.2337/diacare.27.6.1487
   Xie HS, 1996, AM J PHYSIOL-ENDOC M, V270, pE858, DOI 10.1152/ajpendo.1996.270.5.E858
NR 20
TC 19
Z9 21
U1 0
U2 1
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD OCT
PY 2009
VL 87
IS 10
SI SI
BP 873
EP 882
DI 10.1139/Y09-079
PG 10
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 524KV
UT WOS:000272143100016
PM 20052013
DA 2025-06-11
ER

PT J
AU Shyam, S
   Gómez-Martínez, C
   Paz-Graniel, I
   Gaforio, JJ
   Martínez-González, MA
   Corella, D
   Fitó, M
   Martínez, JA
   Alonso-Gómez, AM
   Wärnberg, J
   Vioque, J
   Romaguera, D
   López-Miranda, J
   Estruch, R
   Tinahones, FJ
   Santos-Lozano, JM
   Serra-Majem, JL
   Bueno-Cavanillas, A
   Tur, JA
   Sánchez, VM
   Pintó, X
   Ramos, M
   Vidal, J
   Alcarria, MM
   Daimiel, L
   Ros, E
   Fernandez-Aranda, F
   Nishi, SK
   Regata, OG
   Toledo, E
   Sorli, JV
   Castañer, O
   Garcia-Rios, A
   Valls-Enguix, R
   Perez-Farinos, N
   Zulet, MA
   Rayó-Gago, E
   Casas, R
   Rivera-Izquierdo, M
   Tojal-Sierra, L
   Damas-Fuentes, M
   Buil-Cosiales, P
   Fernández-Carrion, R
   Goday, A
   Peña-Orihuela, PJ
   Compañ-Gabucio, L
   Diez-Espino, J
   Tello, S
   González-Pinto, A
   de la O, V
   Delgado-Rodríguez, M
   Babio, N
   Salas-Salvadó, J
AF Shyam, Sangeetha
   Gomez-Martinez, Carlos
   Paz-Graniel, Indira
   Gaforio, Jose J.
   Martinez-Gonzalez, Miguel Angel
   Corella, Dolores
   Fito, Montserrat
   Martinez, J. Alfredo
   Alonso-Gomez, Angel M.
   Warnberg, Julia
   Vioque, Jesus
   Romaguera, Dora
   Lopez-Miranda, Jose
   Estruch, Ramon
   Tinahones, Francisco J.
   Santos-Lozano, Jose Manuel
   Serra-Majem, J. Luis
   Bueno-Cavanillas, Aurora
   Tur, Josep A.
   Sanchez, Vicente Martin
   Pinto, Xavier
   Ramos, Maria
   Vidal, Josep
   Alcarria, Maria Mar
   Daimiel, Lidia
   Ros, Emilio
   Fernandez-Aranda, Fernando
   Nishi, Stephanie K.
   Regata, Oscar Garcia
   Toledo, Estefania
   Sorli, Jose V.
   Castaner, Olga
   Garcia-Rios, Antonio
   Valls-Enguix, Rafael
   Perez-Farinos, Napoleon
   Zulet, M. Angeles
   Rayo-Gago, Elena
   Casas, Rosa
   Rivera-Izquierdo, Mario
   Tojal-Sierra, Lucas
   Damas-Fuentes, Miguel
   Buil-Cosiales, Pilar
   Fernandez-Carrion, Rebeca
   Goday, Albert
   Pena-Orihuela, Patricia J.
   Compan-Gabucio, Laura
   Diez-Espino, Javier
   Tello, Susanna
   Gonzalez-Pinto, Ana
   de la O, Victor
   Delgado-Rodriguez, Miguel
   Babio, Nancy
   Salas-Salvado, Jordi
TI Coronavirus disease 2019 is associated with long-term depressive
   symptoms in Spanish older adults with overweight/obesity and metabolic
   syndrome
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE COVID-19; depression; older adults; PREDIMED-Plus; SARS-CoV-2
AB Background. The coronavirus disease 2019 (COVID-19) has serious physiological and psychological consequences. The long-term (>12 weeks post-infection) impact of COVID19 on mental health, specifically in older adults, is unclear. We longitudinally assessed the association of COVID-19 with depression symptomatology in community-dwelling older adults with metabolic syndrome within the framework of the PREDIMED-Plus cohort.
   Methods. Participants (n = 5486) aged 55-75 years were included in this longitudinal cohort. COVID-19 status ( positive/negative) determined by tests (e.g. polymerase chain reaction severe acute respiratory syndrome coronavirus 2, IgG) was confirmed via event adjudication (410 cases). Pre- and post-COVID-19 depressive symptomatology was ascertained from annual assessments conducted using a validated 21-item Spanish Beck Depression Inventory-II (BDI-II). Multivariable linear and logistic regression models assessed the association between COVID-19 and depression symptomatology.
   Results. COVID-19 in older adults was associated with higher post-COVID-19 BDI-II scores measured at a median (interquartile range) of 29 (15-40) weeks post-infection [fully adjusted ss = 0.65 points, 95% confidence interval (CI) 0.15-1.15; p = 0.011]. This association was particularly prominent in women (ss = 1.38 points, 95% CI 0.44-2.33, p = 0.004). COVID-19 was associated with 62% increased odds of elevated depression risk (BDI-II >= 14) post-COVID-19 when adjusted for confounders (odds ratio; 95% CI 1.13-2.30, p = 0.008).
   Conclusions. COVID-19 was associated with long-term depression risk in older adults with overweight/obesity and metabolic syndrome, particularly in women. Thus, long-term evaluations of the impact of COVID-19 on mental health and preventive public health initiatives are warranted in older adults.
C1 [Shyam, Sangeetha; Gomez-Martinez, Carlos; Paz-Graniel, Indira; Martinez-Gonzalez, Miguel Angel; Corella, Dolores; Fito, Montserrat; Martinez, J. Alfredo; Alonso-Gomez, Angel M.; Warnberg, Julia; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Tinahones, Francisco J.; Santos-Lozano, Jose Manuel; Serra-Majem, J. Luis; Tur, Josep A.; Pinto, Xavier; Daimiel, Lidia; Ros, Emilio; Fernandez-Aranda, Fernando; Nishi, Stephanie K.; Toledo, Estefania; Sorli, Jose V.; Garcia-Rios, Antonio; Perez-Farinos, Napoleon; Zulet, M. Angeles; Casas, Rosa; Tojal-Sierra, Lucas; Buil-Cosiales, Pilar; Fernandez-Carrion, Rebeca; Pena-Orihuela, Patricia J.; Diez-Espino, Javier; de la O, Victor; Babio, Nancy; Salas-Salvado, Jordi] Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr C, Madrid, Spain.
   [Shyam, Sangeetha; Gomez-Martinez, Carlos; Paz-Graniel, Indira; Nishi, Stephanie K.; Babio, Nancy; Salas-Salvado, Jordi] Univ Rovirai I Virgili, Dept Bioquim & Biotecnol, Grp Alimentacio Nutr Desenvolupament & Salut Menta, Unitat Nutr Humana, Reus, Spain.
   [Shyam, Sangeetha; Gomez-Martinez, Carlos; Paz-Graniel, Indira; Nishi, Stephanie K.; Babio, Nancy; Salas-Salvado, Jordi] Inst Invest Sanitaria Pere Virgili IISPV, Reus, Spain.
   [Gaforio, Jose J.; Vioque, Jesus; Bueno-Cavanillas, Aurora; Sanchez, Vicente Martin; Compan-Gabucio, Laura] Inst Salud Carlos III ISCIII, CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.
   [Gaforio, Jose J.] Univ Jaen, Inst Univ Invest Olivar & Aceites Oliva, Dept Ciencias Salud, Jaen, Spain.
   [Martinez-Gonzalez, Miguel Angel; Toledo, Estefania; Buil-Cosiales, Pilar; Diez-Espino, Javier] Univ Navarra, Dept Prevent Med & Publ Hlth, Inst Invest Sanitaria Navarra IdiSNA, Pamplona, Spain.
   [Martinez-Gonzalez, Miguel Angel] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
   [Corella, Dolores; Sorli, Jose V.; Fernandez-Carrion, Rebeca] Univ Valencia, Dept Prevent Med, Valencia, Spain.
   [Fito, Montserrat; Castaner, Olga; Goday, Albert; Tello, Susanna] Inst Hosp del Mar Invest Med Municipal Invest Med, Unit Cardiovasc Risk & Nutr, Barcelona, Spain.
   [Martinez, J. Alfredo; Zulet, M. Angeles] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona, Spain.
   [Martinez, J. Alfredo; Sanchez, Vicente Martin; Delgado-Rodriguez, Miguel] CEI UAM CSIC, Precis Nutr & Cardiometab Hlth Program, IEA Food, Madrid, Spain.
   [Alonso-Gomez, Angel M.; Tojal-Sierra, Lucas] Araba Univ Hosp, Univ Basque Country UPV, Vitoria, Spain.
   [Alonso-Gomez, Angel M.; Tojal-Sierra, Lucas] Araba Univ Hosp, Osakidetza Basque Hlth Serv, Vitoria, Spain.
   [Alonso-Gomez, Angel M.; Tojal-Sierra, Lucas] Univ Basque Country UPV EHU, Vitoria, Spain.
   [Warnberg, Julia; Perez-Farinos, Napoleon] Univ Malaga, Sch Hlth Sci, Inst Invest Biomed Malaga IBIMA, EpiPHAAN Res Grp, Malaga, Spain.
   [Vioque, Jesus; Compan-Gabucio, Laura] Univ Miguel Hernandez ISABIAL UMH, Inst Invest Sanitaria & Biomed Alicante, Alicante, Spain.
   [Romaguera, Dora; Rayo-Gago, Elena] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca, Spain.
   [Lopez-Miranda, Jose; Garcia-Rios, Antonio; Pena-Orihuela, Patricia J.] Univ Cordoba, Reina Sofia Univ Hosp, Dept Internal Med, Maimonides Biomed Res Inst Cordoba IMIBIC, Cordoba, Spain.
   [Estruch, Ramon; Casas, Rosa] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Internal Med, Barcelona, Spain.
   [Estruch, Ramon; Casas, Rosa] Univ Barcelona, Inst Recerca Nutr & Seguretat Alimentaria INSA UB, Barcelona, Spain.
   [Tinahones, Francisco J.; Damas-Fuentes, Miguel] Univ Malaga, Virgen de la Victoria Hosp, Dept Endocrinol, Inst Invest Biomed Malaga IBIMA, Malaga, Spain.
   [Santos-Lozano, Jose Manuel] Dist Sanitario Atenc Primaria Sevilla, Dept Familiy Med, Res Unit, Seville, Spain.
   [Serra-Majem, J. Luis] Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci IUIBS, Las Palmas Gran Canaria, Spain.
   [Serra-Majem, J. Luis] Ctr Hosp Univ Insular Materno Infantil CHUIMI, Canarian Hlth Serv, Las Palmas Gran Canaria, Spain.
   [Bueno-Cavanillas, Aurora; Rivera-Izquierdo, Mario] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain.
   [Tur, Josep A.] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain.
   [Sanchez, Vicente Martin] Univ Leon, Inst Biomed IBIOMED, Leon, Spain.
   [Pinto, Xavier] Hosp Univ Bellvitge IDIBELL, Internal Med, Lipids & Vasc Risk Unit, Hospitalet De Llobregat B, Barcelona, Spain.
   [Ramos, Maria] Inst Invest Sanitaria Hosp Clin San Carlos IdISSC, Dept Endocrinol & Nutr, Madrid, Spain.
   [Vidal, Josep] Inst Salud Carlos III ISCIII, CIBER Diabet & Enfermedades Metab CIBERDEM, Madrid, Spain.
   [Vidal, Josep] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol, Barcelona, Spain.
   [Alcarria, Maria Mar] Univ Autonoma, Hosp Fdn Jimenez Diaz, Dept Endocrinol & Nutr, Inst Invest Biomed IISFJD, Madrid, Spain.
   [Daimiel, Lidia] CEI UAM CSIC, IMDEA Food, Precis Nutr & Obes Program, Nutr Contro,Epigenome Grp, Madrid, Spain.
   [Ros, Emilio] Hosp Clin Barcelona, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol & Nutr, Lipid Clin, Barcelona, Spain.
   [Daimiel, Lidia] Univ San Pablo CEU, CEU Univ, Fac Farm, Dept Ciencias Farmaceut & Salud, Boadilla Del Monte, Spain.
   [Fernandez-Aranda, Fernando] Inst Invest Biomed Bellvitge IDIBELL, Psychoneurobiol Eating & Addict Behav Grp, Barcelona, Spain.
   [Fernandez-Aranda, Fernando] Univ Hosp Bellvitge, Dept Psychiat, Barcelona, Spain.
   [Fernandez-Aranda, Fernando] Univ Barcelona, Barcelona, Spain.
   [Nishi, Stephanie K.] Toronto 3D Diet Digest Tract & Dis, Knowledge Synth & Clin Trials Unit, Toronto, ON, Canada.
   [Regata, Oscar Garcia] Univ Hosp Araba, Dept Internal Med, OSI ARABA, Vitoria, Spain.
   [Valls-Enguix, Rafael] Hlth Care Ctr Raval Elche, Elche, Spain.
   [Buil-Cosiales, Pilar; Diez-Espino, Javier] Serv Navarro Salud, Atenc Primaria, Pamplona, Spain.
   [Gonzalez-Pinto, Ana] Araba Univ Hosp, Bioaraba Hlth Res Inst, Dept Psychiat, Osakidetza Basque Hlth Serv, Vitoria, Spain.
   [Gonzalez-Pinto, Ana] Univ Basque Country UPV EHU, CIBERSAM, Vitoria, Spain.
   [Delgado-Rodriguez, Miguel] Univ Jaen, Fac Med, Div Prevent Med, Jaen, Spain.
C3 Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV); CIBER - Centro de Investigacion Biomedica en Red;
   CIBERESP; Universidad de Jaen; University of Navarra; Harvard
   University; Harvard T.H. Chan School of Public Health; University of
   Valencia; University of Navarra; Consejo Superior de Investigaciones
   Cientificas (CSIC); University Hospital of Araba; University of Basque
   Country; University Hospital of Araba; University of Basque Country;
   Instituto de Investigacion Biomedica de Malaga y Plataforma en
   Nanomedicina (IBIMA); Universidad de Malaga; General University Hospital
   of Alicante; Universidad Miguel Hernandez de Elche; Universitat
   d'Alacant; Instituto de Investigacion Sanitaria y Biomedica de Alicante
   (ISABIAL); Institut Investigacio Sanitaria Illes Balears (IdISBa);
   Universidad de Cordoba; University of Barcelona; Hospital Clinic de
   Barcelona; IDIBAPS; University of Barcelona; Instituto de Investigacion
   Biomedica de Malaga y Plataforma en Nanomedicina (IBIMA); Universidad de
   Malaga; Universidad de Las Palmas de Gran Canaria; University of
   Granada; Universitat de les Illes Balears; Universidad de Leon; Institut
   d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge University
   Hospital; CIBER - Centro de Investigacion Biomedica en Red; CIBERDEM;
   University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS;
   Autonomous University of Madrid; Fundacion Jimenez Diaz; Consejo
   Superior de Investigaciones Cientificas (CSIC); IMDEA Food Institute;
   University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; San
   Pablo CEU University; Institut d'Investigacio Biomedica de Bellvitge
   (IDIBELL); Institut d'Investigacio Biomedica de Bellvitge (IDIBELL);
   Bellvitge University Hospital; University of Barcelona; University of
   Barcelona; University Hospital of Araba; Servicio Navarro de Salud -
   Osasunbidea; Bioaraba Health Research Institute; University Hospital of
   Araba; University of Basque Country; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERSAM; Universidad de Jaen
RP Shyam, S; Babio, N (corresponding author), Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr C, Madrid, Spain.; Shyam, S; Babio, N (corresponding author), Univ Rovirai I Virgili, Dept Bioquim & Biotecnol, Grp Alimentacio Nutr Desenvolupament & Salut Menta, Unitat Nutr Humana, Reus, Spain.; Shyam, S; Babio, N (corresponding author), Inst Invest Sanitaria Pere Virgili IISPV, Reus, Spain.
EM Sangeetha.shyam@urv.cat; nancy.babio@urv.cat
RI ALONSO GOMEZ, ANGEL/HLG-2476-2023; Tejada, Silvia/L-7297-2014; Martin,
   Vicente/A-1597-2008; Pintó, Xavier/AGI-4297-2022; Castaner,
   Olga/F-1533-2013; Paz-Graniel, Indira/ABH-2583-2020; Babio,
   Nancy/AAN-2715-2020; Estruch, Ramon/AAZ-3723-2020; Romaguera,
   Dora/ABE-7004-2020; Vioque, Jesus/A-1066-2008; Bueno-Cavanillas,
   Aurora/O-1513-2015; Corella, Dolores/L-9888-2014; Gabucio,
   Laura/AAN-6068-2020; Fernandez-Carrion, Rebeca/AAA-5713-2019; Rodríguez,
   Miguel/KCZ-1828-2024; Casas, Rosa/ABD-1915-2020; Tur,
   Josep/AAE-5748-2020; Martinez-Gonzalez, Miguel/AAE-7669-2019; Sorlí,
   José/L-8758-2014; Toledo, Estefania/H-6211-2014; Ortiz Ramos,
   María/GYV-2493-2022; Torres, Miguel/HZK-8113-2023; Lopez-Miranda,
   Jose/Y-8306-2019; Nishi, Stephanie/GSN-1143-2022; Tinahones,
   Francisco/AAB-2882-2020; Serra-Majem, Lluis/I-6708-2019; Daimiel-Ruiz,
   Lidia/M-7779-2014; Rivera-Izquierdo, Mario/AAJ-8726-2021; Vidal,
   Josep/MIK-6936-2025; Gomez Martinez, Carlos/AGJ-6387-2022; Fito Colomer,
   Montse/C-1822-2012; Delgado Rodriguez, Miguel/H-4940-2017;
   FERNANDEZ-ARANDA, FERNANDO/L-9762-2014; Salas-Salvado,
   Jordi/C-7229-2017; Shyam, Sangeetha/G-4636-2013
OI BABIO SANCHEZ, NANCY/0000-0003-3527-5277; Gomez Martinez,
   Carlos/0000-0002-3077-6702; Casas, Rosa/0000-0002-0211-9166; Pena
   Orihuela, Patricia J/0009-0009-9970-043X; Fito Colomer,
   Montse/0000-0002-1817-483X; Lopez-Miranda, Jose/0000-0002-8844-0718;
   Delgado Rodriguez, Miguel/0000-0002-3838-2548; Tojal Sierra,
   Lucas/0000-0001-5338-9601; Tinahones, Francisco J/0000-0001-6871-4403;
   Nishi, Stephanie/0000-0002-7878-5368; Sorli, Jose V/0000-0002-0130-2006;
   FERNANDEZ-ARANDA, FERNANDO/0000-0002-2968-9898; Paz Graniel,
   Indira/0000-0002-3204-6877; Ortiz Ramos, Maria/0000-0003-2187-8907;
   Salas-Salvado, Jordi/0000-0003-2700-7459; Shyam,
   Sangeetha/0000-0002-3340-1519
FU Fundacion Francisco Soria Melguizo; CIBER Fisiopatologia de la Obesidad
   y Nutricion (CIBEROBN); Instituto de Salud Carlos III (ISCIII);
   Implementacion y evaluacion de una intervencion intensiva sobre la
   actividad fisica Cohorte PREDIMED-Plus grant; European Research Council
   [340918]; Recercaixa [2013ACUP00194]; Consejeria de Salud de laJunta de
   Andalucia [PI0458/2013, PS0358/2016, PI0137/2018]; Generalitat
   Valenciana [PROMETEO/2017/017, PROMETEO 21/2021]; SEMERGEN grant; Juan
   de la Cierva-Incorporacion research grant of the Spanish Ministry of
   Economy, Industry and Competitiveness and European Social Funds
   [IJC2019-042420-I]; EU [H2020-SFS-2016-2]; Horizon 2020 PRIME study
   (Prevention and Remediation of Insulin Multimorbidity in Europe)
   [847879]; Maria Zambrano Fellowship; Ministry of Universities; Recovery,
   Transformation and Resilience Plan, Spain; European
   Union-NextGenerationEU; Canadian Institutes of Health Research(CIHR)
   [MFE-171207]; University of Rovira I Virgili [2020PMF-PIPF-37]; ICREA
FX This work was supported by a project grant from the Fundacion Francisco
   Soria Melguizo. The PREDIMED-Plus trial was supported by the official
   Spanish Institutions for funding scientific biomedical research, CIBER
   Fisiopatologia de la Obesidad y Nutricion (CIBEROBN) and Instituto de
   Salud Carlos III (ISCIII), through the Fondo de Investigacion para la
   Salud (FIS), which is co-funded by the European Regional Development
   Fund (six coordinated FIS projects leaded by J. S.-S.and J. Vi.,
   including the following projects: PI13/00673, PI13/00492, PI13/00272,
   PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090,
   PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206,
   PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471,
   PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533,
   PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183,
   PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215,
   PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386,
   PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781,
   PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456,
   PI20/00339, PI20/00557, PI20/00886, PI20/01158); the Especial &
   nbsp;Action Project entitled: Implementacion y evaluacion de una
   intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus
   grant to J. S.-S.; the European Research Council (Advanced Research
   Grant 2014-2019; agreement #340918) granted to M. A. M.-G.; the
   Recercaixa (number 2013ACUP00194) grant to J. S.-S.; grants from the
   Consejeria de Salud de laJunta de Andalucia (PI0458/2013, PS0358/2016,
   and PI0137/2018); the PROMETEO/2017/017 and PROMETEO 21/2021 grants from
   the Generalitat Valenciana; the SEMERGEN grant; Juan de la
   Cierva-Incorporacion research grant (IJC2019-042420-I) of the Spanish
   Ministry of Economy, Industry and Competitiveness and European Social
   Funds. This research was also partially funded by EU-H2020
   Grants(Eat2beNICE/ H2020-SFS-2016-2); and the Horizon 2020 PRIME study
   (Prevention and Remediation of Insulin Multimorbidity in Europe; grant
   agreement #847879). S. G. S. was a recipient of the Maria Zambrano
   Fellowship with funding support from the Ministry of Universities and
   the Recovery, Transformation and Resilience Plan, Spain. The Fellowship
   is Funded by the European Union-NextGenerationEU'. S. K. N. was
   supported by a postdoctoral fellowship from the Canadian Institutes of
   Health Research(CIHR, MFE-171207). C. G.-M. was supported by a
   predoctoral grant from the University of Rovira I Virgili
   (2020PMF-PIPF-37). J. S.-S. was partially supported by ICREA under the
   ICREA Academia program. We thank CERCA Programme/Generalitat de
   Catalunya for institutional support. The funders had no role in study
   design, data collection and analysis, the decision to publish, or the
   preparation of the manuscript
CR Becker A. B., 1996, BDI 2 BECK DEPRESSIO
   Castro A, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph182413268
   CDC, 2020, Labs
   Channappanavar R, 2020, J CLIN INVEST, V130, P6204, DOI 10.1172/JCI144115
   Chen SQ, 2022, J AFFECT DISORDERS, V298, P396, DOI 10.1016/j.jad.2021.10.134
   Deng JW, 2021, ANN NY ACAD SCI, V1486, P90, DOI 10.1111/nyas.14506
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   Fernández-Sevillano J, 2022, WORLD J BIOL PSYCHIA, V23, P307, DOI 10.1080/15622975.2021.1988703
   Guo PY, 2022, FRONT AGING NEUROSCI, V14, DOI 10.3389/fnagi.2022.804922
   Khaledi M, 2019, ACTA DIABETOL, V56, P631, DOI 10.1007/s00592-019-01295-9
   Kim HC, 2018, PSYCHIAT INVEST, V15, P355, DOI 10.30773/pi.2017.10.25.1
   Klaser K, 2021, J NEUROL NEUROSUR PS, V92, P1254, DOI 10.1136/jnnp-2021-327565
   Lopez-Leon S, 2021, SCI REP-UK, V11, DOI [10.1038/s41598-021-95565-8, 10.21203/rs.3.rs-266574/v1, 10.1101/2021.01.27.21250617]
   Silva NMLE, 2022, NEUROPHARMACOLOGY, V209, DOI 10.1016/j.neuropharm.2022.109023
   Martínez-Cengotitabengoa M, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17122022
   Martínez-González MA, 2019, INT J EPIDEMIOL, V48, P387, DOI 10.1093/ije/dyy225
   Mazza MG, 2020, BRAIN BEHAV IMMUN, V89, P594, DOI 10.1016/j.bbi.2020.07.037
   Meng H, 2020, PSYCHIAT RES, V289, DOI 10.1016/j.psychres.2020.112983
   Mueller AL, 2020, AGING-US, V12, P9959, DOI 10.18632/aging.103344
   Pano O, 2021, WORLD J PSYCHIATR, V11, P997, DOI 10.5498/wjp.v11.i11.997
   Paz-Graniel I, 2023, DEPRESS ANXIETY, V2023, DOI 10.1155/2023/6765950
   Pollán M, 2020, LANCET, V396, P535, DOI 10.1016/S0140-6736(20)31483-5
   Renaud-Charest O, 2021, J PSYCHIATR RES, V144, P129, DOI 10.1016/j.jpsychires.2021.09.054
   Robinson E, 2022, J AFFECT DISORDERS, V296, P567, DOI 10.1016/j.jad.2021.09.098
   Salas-Salvadó J, 2019, DIABETES CARE, V42, P777, DOI 10.2337/dc18-0836
   Sanz J., 2003, Clinica y Salud, V14, P249, DOI DOI 10.7334/PSICOTHEMA2012.96
   Sanz J, 2013, PAPEL PSICOL, V34, P161
   Sparks MA, 2020, HYPERTENSION, V76, P1350, DOI 10.1161/HYPERTENSIONAHA.120.15948
   Textor J, 2016, INT J EPIDEMIOL, V45, P1887, DOI 10.1093/ije/dyw341
   Wee AKH, 2021, MED HYPOTHESES, V146, DOI 10.1016/j.mehy.2020.110374
   Wei JK, 2019, BRIT J PSYCHIAT, V215, P449, DOI 10.1192/bjp.2019.74
NR 31
TC 5
Z9 5
U1 0
U2 16
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD FEB
PY 2024
VL 54
IS 3
BP 620
EP 630
DI 10.1017/S0033291723002313
EA SEP 2023
PG 11
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA C7C7A
UT WOS:001067521900001
PM 37667630
DA 2025-06-11
ER

PT J
AU Làmbert, C
   Panagiotopoulos, C
   Davidson, J
   Goldman, RD
AF Lambert, Clare
   Panagiotopoulos, Constadina
   Davidson, Jana
   Goldman, Ran D.
TI Second-Generation Antipsychotic Use in Pediatric Emergency Medicine
SO PEDIATRIC EMERGENCY CARE
LA English
DT Review
DE second-generation antipsychotics; metabolic syndrome; SGA monitoring
ID MENTAL-HEALTH PROBLEMS; METABOLIC SYNDROME; CHILDREN; ADOLESCENTS;
   RECOMMENDATIONS; COMPLICATIONS; POPULATION; VISITS; YOUTH; RATES
AB In recent years, the number of patients presenting to the emergency department with mental health complaints has been growing, alongside an increase in second-generation antipsychotic (SGAs) prescriptions for a variety of mental health conditions. Children treated with SGAs may have abnormalities, such as rapid weight gain and central adiposity, glucose intolerance, dyslipidemia, and hypertension; they may present to the pediatric emergency department with components of metabolic syndrome or type 2 diabetes, and a subsequent significant risk for cardiovascular complications later in life. Pediatric emergency department providers may serve as a safety net for patients to detect SGA-related metabolic complications, especially among vulnerable populations lacking access to primary care or psychiatric services.
C1 [Lambert, Clare; Goldman, Ran D.] Univ British Columbia, Pediat Res Emergency Therapeut PRETx Program, Div Pediat Emergency Med, Vancouver, BC, Canada.
   [Panagiotopoulos, Constadina] Univ British Columbia, Dept Pediat, Div Endocrinol, Vancouver, BC, Canada.
   [Davidson, Jana] Univ British Columbia, Dept Psychiat, Vancouver, BC, Canada.
   [Goldman, Ran D.] BC Childrens Hosp Res Inst, Vancouver, BC, Canada.
C3 University of British Columbia; University of British Columbia;
   University of British Columbia; BC Children's Hospital; BC Children's
   Hospital Research Institute
RP Goldman, RD (corresponding author), BC Childrens Hosp, Div Pediat Emergency Med, Vancouver, BC, Canada.
EM ClareLambert@rcsi.ie; dpanagiotopoulos@cw.bc.ca; jxdavidson@cw.bc.ca;
   rgoldman@cw.bc.ca
RI Lambert, Clare/NCV-8868-2025; Panagiotopoulos, Constadina/AAO-6827-2020
OI Goldman, Ran D./0000-0001-8318-5415
CR [Anonymous], 2018, ORANGE BOOK DATABASE
   [Anonymous], 2020, PEDIAT PSYCHOPHARMAC
   Baren JM, 2008, PEDIATR EMERG CARE, V24, P399, DOI 10.1097/PEC.0b013e318177a6c6
   Bishop TF, 2014, JAMA PSYCHIAT, V71, P176, DOI 10.1001/jamapsychiatry.2013.2862
   Chen WX, 2018, CLIN DRUG INVEST, V38, P449, DOI 10.1007/s40261-018-0626-4
   Christian R, 2012, FUTURE RES NEEDS 1 A
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Connolly JG, 2015, PSYCHIAT SERV, V66, P604, DOI 10.1176/appi.ps.201400222
   Correll CU, 2008, J AM ACAD CHILD PSY, V47, P9, DOI 10.1097/chi.0b013e31815b5cb1
   Correll CU, 2009, JAMA-J AM MED ASSOC, V302, P1765, DOI 10.1001/jama.2009.1549
   Coughlin M, 2018, CAN J PSYCHIAT, V63, P240, DOI 10.1177/0706743717751693
   Crystal S, 2009, HEALTH AFFAIR, V28, pW770, DOI 10.1377/hlthaff.28.5.w770
   Cutler GJ, 2019, ACAD PEDIATR, V19, P948, DOI 10.1016/j.acap.2019.05.132
   Dolan MA, 2011, PEDIATRICS, V127, pE1356, DOI 10.1542/peds.2011-0522
   Donofrio JJ, 2014, ANN EMERG MED, V63, P666, DOI 10.1016/j.annemergmed.2013.10.011
   Gill PJ, 2017, J AM ACAD CHILD PSY, V56, P475, DOI 10.1016/j.jaac.2017.03.012
   Hampton LM, 2015, JAMA PSYCHIAT, V72, P292, DOI 10.1001/jamapsychiatry.2014.2412
   Hayden JD, 2020, J CHILD ADOL PSYCHOP, V30, P119, DOI 10.1089/cap.2019.0087
   Ho J, 2011, PAED CHILD HEALT-CAN, V16, P575, DOI 10.1093/pch/16.9.575
   Kangovi S, 2013, HEALTH AFFAIR, V32, P1196, DOI 10.1377/hlthaff.2012.0825
   Kasper S., 1999, European Archives of Psychiatry and Clinical Neuroscience, V249, pS83, DOI DOI 10.1007/PL00014189
   Kuehn BM, 2009, JAMA-J AM MED ASSOC, V302, P833, DOI 10.1001/jama.2009.1152
   Kumra S, 2008, SCHIZOPHRENIA BULL, V34, P60, DOI 10.1093/schbul/sbm109
   Magge SN, 2017, PEDIATRICS, V140, DOI 10.1542/peds.2017-1603
   Matsuzawa Y, 2011, J ATHEROSCLER THROMB, V18, P629, DOI 10.5551/jat.7922
   Morrato EH, 2010, ARCH GEN PSYCHIAT, V67, P17, DOI 10.1001/archgenpsychiatry.2009.179
   Muench J, 2010, AM FAM PHYSICIAN, V81, P617
   Murphy AL, 2018, PEDIATR EMERG CARE, V34, P711, DOI 10.1097/PEC.0000000000001037
   Panagiotopoulos C, 2010, PHYS HDB METABOLIC M
   Panagiotopoulos C, 2012, CAN J PSYCHIAT, V57, P34, DOI 10.1177/070674371205700107
   Panagiotopoulos C, 2010, J CAN ACAD CHILD ADO, V19, P124
   Pathak P, 2010, PSYCHIAT SERV, V61, P123, DOI 10.1176/ps.2010.61.2.123
   Pittsenbarger ZE, 2014, ACAD EMERG MED, V21, P25, DOI 10.1111/acem.12282
   Pringsheim T, 2011, DRUG SAFETY, V34, P651, DOI 10.2165/11592020-000000000-00000
   Rasimas JJ, 2012, CLIN PEDIATR EMERG M, V13, P300, DOI 10.1016/j.cpem.2012.09.005
   Reiss F, 2013, SOC SCI MED, V90, P24, DOI 10.1016/j.socscimed.2013.04.026
   Ripoli C, 2017, PEDIAT MED CHIRURG, V39
   Sheridan DC, 2015, PEDIATR EMERG CARE, V31, P555, DOI 10.1097/PEC.0000000000000343
   Sjo CP, 2017, J CHILD ADOL PSYCHOP, V27, P884, DOI 10.1089/cap.2016.0171
   Sohn M, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000003784
   Weiner SG, 2012, PEDIATR EMERG CARE, V28, P869, DOI 10.1097/PEC.0b013e31826763bc
   Weisz D, 2015, AM J MANAG CARE, V21, pE152
   Wilson KM, 2000, ARCH PEDIAT ADOL MED, V154, P361, DOI 10.1001/archpedi.154.4.361
NR 43
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0749-5161
EI 1535-1815
J9 PEDIATR EMERG CARE
JI Pediatr. Emerg. Care
PD MAR
PY 2021
VL 37
IS 3
BP 161
EP 166
PG 6
WC Emergency Medicine; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Emergency Medicine; Pediatrics
GA SK9FG
UT WOS:000656523900018
PM 33651760
DA 2025-06-11
ER

PT J
AU Bujtor, M
AF Bujtor, Melissa
TI Can dietary intake protect against low-grade inflammation in children
   and adolescents?
SO BRAIN BEHAVIOR & IMMUNITY-HEALTH
LA English
DT Article
DE Dietary intake; Dietary pattern; Macronutrients; Biomarkers;
   Inflammation; CRP; Cytokine; Interleukin; Children; Adolescent
ID C-REACTIVE PROTEIN; GLYCEMIC-INDEX DIET; WHOLE-GRAIN INTAKE;
   CARDIOMETABOLIC RISK; SUBCLINICAL INFLAMMATION; CARDIOVASCULAR RISK;
   MEDITERRANEAN DIET; METABOLIC SYNDROME; FIBER INTAKE; NO ASSOCIATION
AB In children and adolescents, chronic low-grade inflammation has been implicated in the pathogenesis of co- and multi-morbid conditions to mental health disorders. Diet quality is a potential mechanism of action that can exacerbate or ameliorate low-grade inflammation; however, the exact way dietary intake can regulate the immune response in children and adolescents is still to be fully understood. In this review, I discuss the current observational and interventional evidence that supports a potential therapeutic role for dietary intake in the amelioration of low-grade inflammation and highlight the need to develop a better understanding of the biological mechanisms underlying and attenuating the associations between dietary intake and low-grade inflammation in children and adolescents.
C1 [Bujtor, Melissa] Kings Coll London, Div Psychol Med, Inst Psychiat Psychol & Neurosci, London, England.
   [Bujtor, Melissa] Deakin Univ, Inst Phys Act & Nutr Res, Sch Exercise & Nutr Sci, Melbourne, Vic, Australia.
C3 University of London; King's College London; Deakin University
RP Bujtor, M (corresponding author), Kings Coll London, Div Psychol Med, Inst Psychiat Psychol & Neurosci, London, England.; Bujtor, M (corresponding author), Deakin Univ, Inst Phys Act & Nutr Res, Sch Exercise & Nutr Sci, Melbourne, Vic, Australia.
EM melissa.bujtor@kcl.ac.uk
RI Bujtor, Melissa/HKV-1724-2023; Pariante, Carmine Maria/B-1297-2011
OI Pariante, Carmine Maria/0000-0002-9132-5091
FU UK Medical Research Council [MR/N029488/1]; European Union [848158]
FX Melissa Bujtor is funded by the UK Medical Research Council (grants
   MR/N029488/1). This project has received & nbsp; funding from the
   European Union's Horizon 2020 research and innovation programme under
   Grant Agreement No 848158.
CR Aeberli I, 2006, AM J CLIN NUTR, V84, P748, DOI 10.1093/ajcn/84.4.748
   Agostinis-Sobrinho C, 2019, EUR J NUTR, V58, P2649, DOI 10.1007/s00394-018-1812-0
   Al-Hamad D, 2017, TRANSL PEDIATR, V6, P397, DOI 10.21037/tp.2017.10.02
   Alisson-Silva F, 2016, MOL ASPECTS MED, V51, P16, DOI 10.1016/j.mam.2016.07.002
   Almeida-de-Souza J, 2018, EUR J CLIN NUTR, V72, P710, DOI 10.1038/s41430-017-0013-x
   Amaral GA, 2020, ENDOCR METAB IMMUNE, V20, P887, DOI 10.2174/1871530319666191116141159
   Arouca A, 2018, EUR J NUTR, V57, P1747, DOI 10.1007/s00394-017-1457-4
   Arya S, 2006, NUTRITION, V22, P865, DOI 10.1016/j.nut.2006.05.002
   Aslam H, 2020, NUTRIENTS, V12, DOI 10.3390/nu12103055
   Au LE, 2012, J ACAD NUTR DIET, V112, P1815, DOI 10.1016/j.jand.2012.07.027
   Barbaresko J, 2013, NUTR REV, V71, P511, DOI 10.1111/nure.12035
   da Silva CTB, 2017, PROG NEURO-PSYCHOPH, V77, P133, DOI 10.1016/j.pnpbp.2017.03.023
   Bennett JM, 2018, FRONT MED-LAUSANNE, V5, DOI 10.3389/fmed.2018.00316
   Berk M, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-200
   Borsini A, 2017, BRAIN BEHAV IMMUN, V65, P230, DOI 10.1016/j.bbi.2017.05.006
   Bowyer RCE, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0455-y
   Bujtor M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020356
   Cabral M, 2018, NUTR METAB CARDIOVAS, V28, P1067, DOI 10.1016/j.numecd.2018.06.003
   Calder PC, 2011, BRIT J NUTR, V106, pS1, DOI 10.1017/S0007114511005460
   Carvalho KMB, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111770
   Casas R, 2014, ENDOCR METAB IMMUNE, V14, P245, DOI 10.2174/1871530314666140922153350
   Cattaneo A, 2020, TRANSL PSYCHIAT, V10, DOI 10.1038/s41398-020-00874-7
   Ping-Delfos WLS, 2015, BRIT J NUTR, V113, P1741, DOI 10.1017/S0007114515001026
   Chang JPC, 2019, TRANSL PSYCHIAT, V9, DOI 10.1038/s41398-019-0633-0
   Chang JPC, 2018, NEUROPSYCHOPHARMACOL, V43, P534, DOI 10.1038/npp.2017.160
   Coheley LM, 2019, OSTEOPOROSIS INT, V30, P1645, DOI 10.1007/s00198-019-04946-3
   Colasanto M, 2020, J AFFECT DISORDERS, V277, P940, DOI 10.1016/j.jad.2020.09.025
   Cunningham-Rundles S, 2005, J ALLERGY CLIN IMMUN, V115, P1119, DOI 10.1016/j.jaci.2005.04.036
   Dai J, 2008, CIRCULATION, V117, P169, DOI 10.1161/CIRCULATIONAHA.107.710699
   Damsgaard CT, 2013, J NUTR, V143, P810, DOI 10.3945/jn.112.173427
   Davis R, 2021, J HUM NUTR DIET, V34, P420, DOI 10.1111/jhn.12812
   de Sousa A.F., 2019, Int. J. Vitam. Nutr. Res.
   Bibiloni MD, 2013, EUR J CLIN NUTR, V67, P1264, DOI 10.1038/ejcn.2013.196
   Demory-Luce D, 2004, J AM DIET ASSOC, V104, P1684, DOI 10.1016/j.jada.2004.07.026
   Douros K, 2019, ALLERGOL IMMUNOPATH, V47, P209, DOI 10.1016/j.aller.2018.04.007
   Dragsted LO, 2018, GENES NUTR, V13, DOI 10.1186/s12263-018-0603-9
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   Foster E, 2014, P NUTR SOC, V73, P201, DOI 10.1017/S0029665114000020
   Furman D, 2019, NAT MED, V25, P1822, DOI 10.1038/s41591-019-0675-0
   Giacobbe J., Inspire The Mind: Inspire The Mind
   Giacobbe J, 2020, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.00122
   Giugliano D, 2006, J AM COLL CARDIOL, V48, P677, DOI 10.1016/j.jacc.2006.03.052
   González-Gil E, 2016, EUR J NUTR, V55, P2459, DOI 10.1007/s00394-015-1054-3
   Grosso G, 2014, CRIT REV FOOD SCI, V54, P593, DOI 10.1080/10408398.2011.596955
   Hagin S, 2017, CHILD HEALTH CARE, V46, P408, DOI 10.1080/02739615.2016.1227935
   Hajihashemi P, 2014, MOL NUTR FOOD RES, V58, P1301, DOI 10.1002/mnfr.201300582
   Han YY, 2015, ANN ALLERG ASTHMA IM, V115, P288, DOI 10.1016/j.anai.2015.07.020
   Harris CP, 2019, BMC PUBLIC HEALTH, V19, DOI 10.1186/s12889-019-7113-6
   Hilger-Kolb J, 2017, NUTR J, V16, DOI 10.1186/s12937-017-0300-3
   Holt EM, 2009, J AM DIET ASSOC, V109, P414, DOI 10.1016/j.jada.2008.11.036
   Hur IY, 2012, J ACAD NUTR DIET, V112, P46, DOI 10.1016/j.jada.2011.08.028
   Iannuzzi A, 2009, HEART VESSELS, V24, P419, DOI 10.1007/s00380-008-1138-6
   Jaacks LM, 2014, J DIABETES COMPLICAT, V28, P305, DOI 10.1016/j.jdiacomp.2014.01.005
   Jacka FN, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024805
   Jacka FN, 2010, AUST NZ J PSYCHIAT, V44, P435, DOI 10.3109/00048670903571598
   Jin R, 2014, NUTRIENTS, V6, P3187, DOI 10.3390/nu6083187
   Kanauchi M, 2019, ANN MED SURG, V47, P44, DOI 10.1016/j.amsu.2019.09.012
   Karampola M, 2019, HIPPOKRATIA, V23, P3
   Khayyatzadeh SS, 2018, EUR J CLIN INVEST, V48, DOI 10.1111/eci.12897
   Kiecolt-Glaser JK, 2015, AM J PSYCHIAT, V172, P1075, DOI 10.1176/appi.ajp.2015.15020152
   King DE, 2007, MAGNESIUM RES, V20, P32
   Kohlboeck G, 2012, ANN NUTR METAB, V60, P247, DOI 10.1159/000337552
   Kosova EC, 2013, J ACAD NUTR DIET, V113, P219, DOI 10.1016/j.jand.2012.10.020
   Kurklu NS, 2020, J PEDIATR ENDOCR MET, V33, P495, DOI 10.1515/jpem-2019-0409
   LaRowe TL, 2007, J AM DIET ASSOC, V107, P1124, DOI 10.1016/j.jada.2007.04.013
   Lassale C, 2019, MOL PSYCHIATR, V24, P965, DOI 10.1038/s41380-018-0237-8
   Lazarou C, 2010, CLIN NUTR, V29, P779, DOI 10.1016/j.clnu.2010.05.001
   Li T., 2020, J Dig Dis.
   Liese AD, 2018, J DIABETES COMPLICAT, V32, P179, DOI 10.1016/j.jdiacomp.2017.10.015
   Lin Y, 2015, EUR J NUTR, V54, P771, DOI 10.1007/s00394-014-0756-2
   Livingstone MBE, 2000, P NUTR SOC, V59, P279, DOI 10.1017/S0029665100000318
   Machado AM, 2015, NUTRITION, V31, P90, DOI 10.1016/j.nut.2014.05.002
   Magarey A, 2011, INT J PEDIATR OBES, V6, P2, DOI 10.3109/17477161003728469
   Marx W, 2021, MOL PSYCHIATR, V26, P4158, DOI 10.1038/s41380-020-00951-9
   Miller SJ, 2016, PEDIATR OBES, V11, P33, DOI 10.1111/ijpo.12017
   Minihane AM, 2015, BRIT J NUTR, V114, P999, DOI 10.1017/S0007114515002093
   Mitchell RHB, 2014, J AM ACAD CHILD PSY, V53, P274, DOI 10.1016/j.jaac.2013.11.013
   Monteiro R, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/289645
   Montonen J, 2013, EUR J NUTR, V52, P337, DOI 10.1007/s00394-012-0340-6
   Navarro P, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030224
   Navarro SL, 2016, CANCER EPIDEM BIOMAR, V25, P521, DOI 10.1158/1055-9965.EPI-15-0956
   Oddy W., 2014, Obes. Rev., V15, P120
   Oddy WH, 2018, BRAIN BEHAV IMMUN, V69, P428, DOI 10.1016/j.bbi.2018.01.002
   Okreglicka Katarzyna, 2015, Rocz Panstw Zakl Hig, V66, P97
   Oldewage-Theron W, 2017, PUBLIC HEALTH NUTR, V20, P102, DOI [10.1017/S1368980016001956, 10.1017/s1368980016001956]
   Ortona Elena, 2016, Ann Ist Super Sanita, V52, P205, DOI 10.4415/ANN_16_02_12
   Osimo EF, 2018, PSYCHONEUROENDOCRINO, V91, P226, DOI 10.1016/j.psyneuen.2018.02.031
   Parikh S, 2012, J CLIN ENDOCR METAB, V97, pE1451, DOI 10.1210/jc.2012-1784
   Parillo M, 2012, J ENDOCRINOL INVEST, V35, P629, DOI 10.3275/7909
   Pitharouli MC, 2021, AM J PSYCHIAT, V178, P522, DOI 10.1176/appi.ajp.2020.20060947
   Potischman N, 2003, J NUTR, V133, p875S, DOI 10.1093/jn/133.3.875S
   Prihaningtyas R., 2019, Dietary Intakes and High Sensitivity CRP (hsCRP) in Adolescents with Obesity
   Qureshi MM, 2009, NUTR METAB, V6, DOI 10.1186/1743-7075-6-40
   Reilly SM, 2017, NAT REV ENDOCRINOL, V13, P633, DOI 10.1038/nrendo.2017.90
   Reinehr T, 2019, CLIN CHIM ACTA, V496, P100, DOI 10.1016/j.cca.2019.07.006
   Rocha NP, 2017, J PEDIAT-BRAZIL, V93, P214, DOI 10.1016/j.jped.2017.01.002
   Rouhani MH, 2016, HORM METAB RES, V48, P251, DOI 10.1055/s-0042-100467
   Saneei P, 2014, ANN NUTR METAB, V64, P20, DOI 10.1159/000358341
   Sanjeevi N, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101552
   Sawyer KM, 2019, MOL PSYCHIATR, V24, P1157, DOI 10.1038/s41380-018-0265-4
   Schultz H, 2021, AM J LIFESTYLE MED, V15, P634, DOI 10.1177/1559827619894954
   Sen S, 2018, PEDIATR OBES, V13, P292, DOI 10.1111/ijpo.12221
   Shivappa N, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600707
   Silveira B.K.S., 2018, Cardiol. Res. Pract., P1
   Singh J, 2015, PEDIATR CARDIOL, V36, P1338, DOI 10.1007/s00246-015-1162-0
   Stein DJ, 2019, BMJ-BRIT MED J, V364, DOI 10.1136/bmj.l295
   Stroescu RF, 2019, J PEDIATR ENDOCR MET, V32, P27, DOI 10.1515/jpem-2018-0378
   Suhett LG, 2021, CRIT REV FOOD SCI, V61, P407, DOI 10.1080/10408398.2020.1734911
   Sun CH, 2011, NUTR METAB CARDIOVAS, V21, P576, DOI 10.1016/j.numecd.2009.12.014
   Sureda A, 2018, NUTRIENTS, V10, DOI 10.3390/nu10010062
   Swann O.G., 2020, Br. J. Nutr., P1
   Tabung FK, 2016, J NUTR, V146, P1560, DOI 10.3945/jn.115.228718
   Tapsell LC, 2016, ADV NUTR, V7, P445, DOI 10.3945/an.115.011718
   Thomas NE, 2008, BRIT J SPORT MED, V42, DOI 10.1136/bjsm.2007.043604
   Tworoger SS, 2006, CANCER CAUSE CONTROL, V17, P889, DOI 10.1007/s10552-006-0035-5
   van der Velde LA, 2019, EUR J NUTR, V58, P1259, DOI 10.1007/s00394-018-1651-z
   Vyncke KE, 2013, NUTRITION, V29, P411, DOI 10.1016/j.nut.2012.07.007
   Whitacre CC, 2001, NAT IMMUNOL, V2, P777, DOI 10.1038/ni0901-777
   Yilmaz FÇ, 2019, ECOL FOOD NUTR, V58, P207, DOI 10.1080/03670244.2019.1580581
   Zhu HD, 2014, PEDIATRICS, V133, pE635, DOI 10.1542/peds.2013-1794
   Zolin SJ, 2015, J TRAUMA ACUTE CARE, V78, P451, DOI 10.1097/TA.0000000000000550
   Zunszain Patricia A, 2013, Curr Top Behav Neurosci, V14, P135, DOI 10.1007/7854_2012_211
NR 122
TC 3
Z9 3
U1 2
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2666-3546
J9 BRAIN BEHAV IMMUN-HL
JI Brain Behav. Immun.-Health
PD DEC
PY 2021
VL 18
AR 100369
DI 10.1016/j.bbih.2021.100369
PG 7
WC Immunology; Neurosciences; Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA Q7GD4
UT WOS:001059160700015
PM 34825233
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rosmond, R
AF Rosmond, R
TI Role of stress in the pathogenesis of the metabolic syndrome
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE disease; environment; genes; metabolic syndrome; obesity; stress
ID GLUCOCORTICOID-RECEPTOR GENE; PITUITARY-ADRENAL AXIS;
   INSULIN-RESISTANCE; ABDOMINAL OBESITY; SYNDROME-X; IN-VITRO; CORTISOL;
   DEXAMETHASONE; POLYMORPHISM; POPULATION
AB Excess body fat, obesity, is one of the most common disorders in clinical practice. In addition, there is a clustering of several risk factors with obesity, including hypertension, glucose intolerance, diabetes mellitus, and hyperlipidemia, which is observed more frequently than by chance alone. This has led to the suggestion that these represent a single syndrome and is referred to as the Metabolic Syndrome. A growing body of evidence suggests that glucocorticoid secretion is associated with this complex phenotype. Continuously changing and sometimes threatening external environment may, when the challenge exceeds a threshold, activate central pathways that stimulate the adrenals to release glucocorticoids. In this review, we will discuss how such processes mediate a pathogenetic role in the Metabolic Syndrome. (C) 2004 Elsevier Ltd. All rights reserved.
RP Lundvagen 6, S-43364 Savedalen, Sweden.
EM rolandrosmond@hotmail.com
CR Abdul-Rahim HF, 2001, DIABETES CARE, V24, P275, DOI 10.2337/diacare.24.2.275
   ALDAMLUJI S, 1993, AM J PHYSIOL, V264, pE208, DOI 10.1152/ajpendo.1993.264.2.E208
   AMATRUDA J M, 1985, Diabetes Metabolism Reviews, V1, P293
   Beck-Nielsen H, 1999, DRUGS, V58, P7, DOI 10.2165/00003495-199958001-00003
   BERNARD C, 1878, LECONS PHENOMENONES
   Björntorp P, 2000, BLOOD PRESSURE, V9, P71, DOI 10.1080/08037050050151762
   Bjorntorp P, 1988, Acta Med Scand Suppl, V723, P121
   Bjorntorp P, 1996, INT J OBESITY, V20, P291
   Bjorntorp P, 1993, Obes Res, V1, P206
   BJORNTORP P, 1971, METABOLISM, V20, P927, DOI 10.1016/0026-0495(71)90013-8
   BRANTLEY PJ, 1988, J CONSULT CLIN PSYCH, V56, P549, DOI 10.1037/0022-006X.56.4.549
   Brunner EJ, 1997, DIABETOLOGIA, V40, P1341, DOI 10.1007/s001250050830
   Cai ZJ, 1999, WHO TECH REP SER, V887, P1
   CALOGERO AE, 1988, BRAIN RES, V463, P28, DOI 10.1016/0006-8993(88)90523-9
   Chrousos GP, 1998, J CLIN ENDOCR METAB, V83, P1842, DOI 10.1210/jc.83.6.1842
   Chrousos GP, 1998, ANN NY ACAD SCI, V851, P311, DOI 10.1111/j.1749-6632.1998.tb09006.x
   CHROUSOS GP, 1992, JAMA-J AM MED ASSOC, V267, P1244, DOI 10.1001/jama.267.9.1244
   Clarkson T B, 1989, Cardiovasc Clin, V19, P147
   CLARKSON TB, 1987, CIRCULATION, V76, P29
   Coderre L, 1996, AM J PHYSIOL-ENDOC M, V271, pE643, DOI 10.1152/ajpendo.1996.271.4.E643
   CUMMINS SE, 1993, BEHAV MED, V19, P129, DOI 10.1080/08964289.1993.9935182
   DALLMAN MF, 1993, FRONT NEUROENDOCRIN, V14, P303, DOI 10.1006/frne.1993.1010
   DALLMAN MF, 1993, TRENDS ENDOCRIN MET, V4, P62, DOI 10.1016/S1043-2760(05)80017-7
   DALLMAN MF, 1994, ANN NY ACAD SCI, V746, P22
   DEBOLD CR, 1984, J CLIN INVEST, V73, P533, DOI 10.1172/JCI111240
   DeRijk RH, 2002, J STEROID BIOCHEM, V81, P103, DOI 10.1016/S0960-0760(02)00062-6
   Dinan TG, 1996, LIFE SCI, V58, P1683, DOI 10.1016/0024-3205(96)00066-5
   DUNN JF, 1981, J CLIN ENDOCR METAB, V53, P58, DOI 10.1210/jcem-53-1-58
   Fleury I, 2003, CLIN CHEM, V49, P1528, DOI 10.1373/49.9.1528
   Folkow B, 1997, ACTA PHYSIOL SCAND, V161, P34
   FOLKOW B, 1982, PHYSIOL REV, V62, P347, DOI 10.1152/physrev.1982.62.2.347
   Folkow Bjorn, 1993, Annals of Behavioral Medicine, V15, P236
   GARVEY WT, 1989, ENDOCRINOLOGY, V124, P2063, DOI 10.1210/endo-124-5-2063
   GOSSE P, 1993, EUR HEART J, V14, P16, DOI 10.1093/eurheartj/14.suppl_D.16
   HENRY J P, 1992, Integrative Physiological and Behavioral Science, V27, P66, DOI 10.1007/BF02691093
   HENRY JP, 1990, J HYPERTENS, V8, P783, DOI 10.1097/00004872-199009000-00001
   Herman JP, 1997, TRENDS NEUROSCI, V20, P78, DOI 10.1016/S0166-2236(96)10069-2
   HOLMANG A, 1992, ACTA PHYSIOL SCAND, V144, P425, DOI 10.1111/j.1748-1716.1992.tb09316.x
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   JOELS M, 1994, PROG NEUROBIOL, V43, P1, DOI 10.1016/0301-0082(94)90014-0
   Kaplan JR, 1996, PSYCHOSOM MED, V58, P598, DOI 10.1097/00006842-199611000-00008
   KOUTIS AD, 1992, EUR HEART J, V13, P865, DOI 10.1093/oxfordjournals.eurheartj.a060284
   Lambillotte C, 1997, J CLIN INVEST, V99, P414, DOI 10.1172/JCI119175
   Large V, 1997, J CLIN INVEST, V100, P3005, DOI 10.1172/JCI119854
   LAZARUS RS, 1993, PSYCHOSOM MED, V55, P234, DOI 10.1097/00006842-199305000-00002
   Lee Z. S. K., 2000, Hong Kong Medical Journal, V6, P13
   MARMOT MG, 1986, LANCET, V2, P274
   Mason J W, 1975, J Human Stress, V1, P22
   MASON JW, 1971, J PSYCHIAT RES, V8, P323, DOI 10.1016/0022-3956(71)90028-8
   MCEWEN BS, 1993, ARCH INTERN MED, V153, P2093, DOI 10.1001/archinte.153.18.2093
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   Meigs JB, 2003, DIABETES, V52, P2160, DOI 10.2337/diabetes.52.8.2160
   MONTKOWSKI A, 1995, J NEUROENDOCRINOL, V7, P841, DOI 10.1111/j.1365-2826.1995.tb00724.x
   MORES N, 1990, J CARDIOVASC PHARM, V16, P411, DOI 10.1097/00005344-199009000-00009
   Must A, 1999, JAMA-J AM MED ASSOC, V282, P1523, DOI 10.1001/jama.282.16.1523
   OTTOSSON M, 1994, J CLIN ENDOCR METAB, V79, P820, DOI 10.1210/jc.79.3.820
   PAGANO G, 1983, J CLIN INVEST, V72, P1814, DOI 10.1172/JCI111141
   PEPIN MC, 1992, NATURE, V355, P725, DOI 10.1038/355725a0
   RAGLAND DR, 1988, NEW ENGL J MED, V318, P65, DOI 10.1056/NEJM198801143180201
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   REBUFFESCRIVE M, 1985, EUR J CLIN INVEST, V15, P267, DOI 10.1111/j.1365-2362.1985.tb00182.x
   REBUFFESCRIVE M, 1990, J CLIN ENDOCR METAB, V71, P1215, DOI 10.1210/jcem-71-5-1215
   REICHLIN S, 1993, NEW ENGL J MED, V329, P1246
   REIHSAUS E, 1993, AM J RESP CELL MOL, V8, P334, DOI 10.1165/ajrcmb/8.3.334
   Reynolds RM, 2002, JAMA-J AM MED ASSOC, V287, P2505, DOI 10.1001/jama.287.19.2505
   Rosmond R, 2000, OBES RES, V8, P445, DOI 10.1038/oby.2000.55
   Rosmond R, 2000, OBES RES, V8, P211, DOI 10.1038/oby.2000.24
   Rosmond R, 2002, OBES RES, V10, P1078, DOI 10.1038/oby.2002.146
   Rosmond R, 2003, INT J OBESITY, V27, P1141, DOI 10.1038/sj.ijo.0802397
   Rosmond R, 2002, INT J OBESITY, V26, P938, DOI 10.1038/sj.ijo.0802022
   Rosmond R., 2001, International textbook of obesity, P339
   Rosmond R, 2001, J CLIN ENDOCR METAB, V86, P2178, DOI 10.1210/jc.86.5.2178
   Rosmond R, 2002, J INTERN MED, V251, P252, DOI 10.1046/j.1365-2796.2002.00961.x
   SAPOLSKY RM, 1986, ENDOCR REV, V7, P284, DOI 10.1210/edrv-7-3-284
   Selye H., 1982, Life Stress, P3
   Selye H., 1975, STRESS LIFE
   SHIVELY CA, 1990, ARTERIOSCLEROSIS, V10, P358, DOI 10.1161/01.ATV.10.3.358
   Skinner J.E., 1985, Stress and Heart Disease, P44
   Sterling P., 1988, Handbook of life stress, cognition, and health, P629
   TAYLOR AL, 1988, NEW ENGL J MED, V319, P213, DOI 10.1056/NEJM198807283190405
   Trevisan M, 1998, AM J EPIDEMIOL, V148, P958
   Ukkola O, 2001, ATHEROSCLEROSIS, V157, P221, DOI 10.1016/S0021-9150(00)00712-7
   Vanhala M J, 1997, J Cardiovasc Risk, V4, P291, DOI 10.1097/00043798-199708000-00010
   Wahrborg P, 1998, EUR HEART J, V19, pO20
   WAJNGOT A, 1990, AM J PHYSIOL, V259, pE626, DOI 10.1152/ajpendo.1990.259.5.E626
   Wannamethee SG, 1998, J HUM HYPERTENS, V12, P735, DOI 10.1038/sj.jhh.1000714
   Wilson A. G., 1992, Human Molecular Genetics, V1, P353, DOI 10.1093/hmg/1.5.353
   Wilson AG, 1997, P NATL ACAD SCI USA, V94, P3195, DOI 10.1073/pnas.94.7.3195
   Yarbrough DE, 1998, DIABETES CARE, V21, P1652, DOI 10.2337/diacare.21.10.1652
   York DA, 1996, ENDOCRIN METAB CLIN, V25, P781, DOI 10.1016/S0889-8529(05)70354-6
NR 90
TC 367
Z9 449
U1 0
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JAN
PY 2005
VL 30
IS 1
BP 1
EP 10
DI 10.1016/j.psyneuen.2004.05.007
PG 10
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 858TL
UT WOS:000224214700001
PM 15358437
DA 2025-06-11
ER

PT J
AU Sud, D
   Maidment, I
   Bradley, E
   Tritter, J
AF Sud, Dolly
   Maidment, Ian
   Bradley, Eleanor
   Tritter, Jonathan
TI The experiences of the caring dyad: (Un)articulated realities of living
   with cardiometabolic risk, metabolic syndrome and related diseases in
   severe mental illness
SO HEALTH EXPECTATIONS
LA English
DT Article
DE dyad; informal carer; patient; qualitative; relationship; schizophrenia;
   thematic analysis
ID SOCIAL SUPPORT; HEALTH-CARE; FOLLOW-UP; SCHIZOPHRENIA; INTERVENTION;
   PSYCHOSIS; MORTALITY; INTERDEPENDENCE; MANAGEMENT; OUTCOMES
AB Background Informal carers play an important role in the care of patients with mental illness. Little is known of the relationship experience of the patient and their informal carer (caring dyad) as the context for the intersection between physical and mental health. Aim This study aimed to explore the impact of comorbid cardiometabolic risk (CMR), metabolic syndrome (MetS) and related diseases and severe mental illness (SMI) on the caring dyad. Design Between October 2018 and March 2020, we conducted 11 in-depth semi-structured interviews across 6 adult caring dyads, interviewing each individual separately. Setting Dyads were recruited within the United Kingdom; informal carers were nominated by the patient as a person who provided a significant amount of support. Variable Being Studied Participants were asked about the impacts of illness and caring on daily life. Data Analysis Data were analysed at the dyad level using thematic analysis, comparing and contrasting responses from each individual. Results Themes were identified: enhanced closeness, dissonance and balance within the caring dyad. Discussion and Conclusions This study uses a particular population of patients with comorbid CMR factors, MetS and related diseases and SMI and their informal carers to explore the relevance and utility of caring dyads as an analytical framework to inform practice and policy. Future interventions should consider factors impacting on dyadic relationships to formulate effective and sustainable dyadic care and treatment to improve health outcomes for both patients with SMI and their informal carers. Patient/Public Involvement In this study, patients and informal carers were participants. Topic guides were piloted with a patient and informal carer.
C1 [Sud, Dolly; Maidment, Ian] Aston Univ, Coll Life & Hlth Sci, Aston Pharm Sch, Birmingham B4 7ET, W Midlands, England.
   [Sud, Dolly] Leicestershire Partnership NHS Trust, Glenfield Hosp Site, Bradgate Mental Hlth Site, Pharmacy Dept, Groby Rd, Leicester LE3 9EJ, Leics, England.
   [Bradley, Eleanor] Univ Worcester, Coll Life Hlth & Environm Sci, Grove, England.
   [Tritter, Jonathan] Aston Univ, Sch Humanities & Social Sci, Birmingham, W Midlands, England.
C3 Aston University; Leicestershire Partnership NHS Trust; University of
   Worcester; Aston University
RP Sud, D (corresponding author), Aston Univ, Coll Life & Hlth Sci, Aston Pharm Sch, Birmingham B4 7ET, W Midlands, England.; Sud, D (corresponding author), Leicestershire Partnership NHS Trust, Glenfield Hosp Site, Bradgate Mental Hlth Site, Pharmacy Dept, Groby Rd, Leicester LE3 9EJ, Leics, England.
EM sudd@aston.ac.uk
RI Sud, Dolly/I-5045-2017; Bradley, Eleanor/AAM-2207-2020
OI SUD, DOLLY/0000-0002-6867-1631; Bradley, Eleanor/0000-0001-5877-2298;
   Tritter, Jonathan Q/0000-0002-1651-2428; Tritter,
   Jonathan/0000-0001-6258-4628; Maidment, Ian/0000-0003-4152-9704
FU Charitable Funds Committee at Leicestershire Partnership NHS Trust;
   Aston University
FX Charitable Funds Committee at Leicestershire Partnership NHS Trust; 50th
   Anniversary Prize Studentship awarded by Aston University
CR Allegrante JP, 2019, ANNU REV PUBL HEALTH, V40, P127, DOI 10.1146/annurev-publhealth-040218-044008
   [Anonymous], 2001, Innovative Care for Chronic Conditions: Building Blocks for Action
   [Anonymous], 2012, The Abandoned Illness: A Report by the Schizophrenia Commission
   [Anonymous], 2014, PSYCH SCHIZ AD NICE
   Aschbrenner KA, 2016, J SOC SOC WORK RES, V7, P289, DOI 10.1086/686486
   Benyamini Y, 2019, HEALTH PSYCHOL REV, V13, P373, DOI 10.1080/17437199.2019.1644189
   BIRCHWOOD M, 1992, BRIT J CLIN PSYCHOL, V31, P257, DOI 10.1111/j.2044-8260.1992.tb00994.x
   Block ES, 2012, INT J QUAL METH, V11, P428, DOI 10.1177/160940691201100409
   Braun V., 2006, QUAL RES PSYCHOL, V3, P77, DOI [DOI 10.1191/1478088706QP063OA, DOI 10.1080/14780887.2020.1769238]
   Braun V, 2021, COUNS PSYCHOTHER RES, V21, P37, DOI 10.1002/capr.12360
   Braun V, 2021, QUAL RES SPORT EXERC, V13, P201, DOI 10.1080/2159676X.2019.1704846
   Bryman, 2013, QUALITATIVE RES PRAC
   Clarke V, 2018, COUNS PSYCHOTHER RES, V18, P107, DOI 10.1002/capr.12165
   Connor C, 2016, EARLY INTERV PSYCHIA, V10, P334, DOI 10.1111/eip.12177
   Cooper SJ, 2016, J PSYCHOPHARMACOL, V30, P717, DOI 10.1177/0269881116645254
   De Hert M, 2009, EUR PSYCHIAT, V24, P412, DOI 10.1016/j.eurpsy.2009.01.005
   Department of Health Public Health England, 2016, IMPR PHYS HLTH PEOPL
   Doyle R, 2014, PSYCHIAT SERV, V65, P603, DOI 10.1176/appi.ps.201200570
   Eisikovits Z, 2010, QUAL HEALTH RES, V20, P1642, DOI 10.1177/1049732310376520
   Garety PA, 2008, BRIT J PSYCHIAT, V192, P412, DOI 10.1192/bjp.bp.107.043570
   Ham C, 2010, HEALTH ECON POLICY L, V5, P71, DOI 10.1017/S1744133109990120
   Kelley H.H., 1983, CLOSE RELATIONSHIPS
   Kelley H.H., 1978, INTERPERSONAL RELATI
   Kuipers E, 2010, BRIT J PSYCHIAT, V196, P259, DOI 10.1192/bjp.bp.109.070466
   Leventhal H., 1980, MED PSYCHOL, V2, P7, DOI DOI 10.1007/BF02090456
   Leventhal Howard., 1997, Health, Coping, and Well-Being: Perspectives from Social Comparison Theory, P411
   Lewis MA, 2006, SOC SCI MED, V62, P1369, DOI 10.1016/j.socscimed.2005.08.006
   Liu NH, 2017, WORLD PSYCHIATRY, V16, P30, DOI 10.1002/wps.20384
   Newman D, 2017, NURSE RES, V25, P37, DOI 10.7748/nr.2017.e1443
   NHS England, IMPR PHYS HEALTHC PE
   Norman RMG, 2005, SCHIZOPHR RES, V80, P227, DOI 10.1016/j.schres.2005.05.006
   NVivo Qualitative Data Analysis Software, NVIVO QUAL DAT AN SO
   Onwumere J, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00668
   Onwumere J, 2018, FRONT PSYCHOL, V9, DOI 10.3389/fpsyg.2018.01530
   Onwumere J, 2018, INT J SOC PSYCHIATR, V64, P381, DOI 10.1177/0020764018763684
   Onwumere J, 2017, J MENT HEALTH, V26, P95, DOI 10.1080/09638237.2017.1301649
   Ösby U, 2000, SCHIZOPHR RES, V45, P21, DOI 10.1016/S0920-9964(99)00191-7
   Pope C, 2000, BMJ-BRIT MED J, V320, P114, DOI 10.1136/bmj.320.7227.114
   Public Health England. NHS Rightcare, NHS RIGHTCARE TOOLK
   Ran MS, 2016, SOC PSYCH PSYCH EPID, V51, P513, DOI 10.1007/s00127-015-1169-0
   Reininghaus U, 2015, SCHIZOPHRENIA BULL, V41, P664, DOI 10.1093/schbul/sbu138
   Reynolds R, 2018, BMC FAM PRACT, V19, DOI 10.1186/s12875-017-0692-3
   Ritchie J., 1994, ANAL QUALITATIVE DAT, P305, DOI [DOI 10.4324/9780203413081, 10.4324/9780203413081]
   Ritchie J., 2003, QUALITATIVE RES PRAC
   Rothman AA, 2003, ANN INTERN MED, V138, P256, DOI 10.7326/0003-4819-138-3-200302040-00034
   Rusbult CE, 2003, ANNU REV PSYCHOL, V54, P351, DOI 10.1146/annurev.psych.54.101601.145059
   Short ME, 2009, J OCCUP ENVIRON MED, V51, P786, DOI 10.1097/JOM.0b013e3181a86671
   Sud D, 2021, RES SOC ADMIN PHARM, V17, P2044, DOI 10.1016/j.sapharm.2021.02.018
   Sud D, 2021, SYST REV-LONDON, V10, DOI 10.1186/s13643-021-01586-9
NR 49
TC 2
Z9 2
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1369-6513
EI 1369-7625
J9 HEALTH EXPECT
JI Health Expect.
PD OCT
PY 2021
VL 24
IS 5
BP 1821
EP 1832
DI 10.1111/hex.13322
EA AUG 2021
PG 12
WC Health Care Sciences & Services; Health Policy & Services; Public,
   Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA UZ1DD
UT WOS:000680096900001
PM 34339575
OA Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Helvaci, N
   Yildiz, BO
AF Helvaci, Nafiye
   Yildiz, Bulent Okan
TI Polycystic ovary syndrome and aging: Health implications after menopause
SO MATURITAS
LA English
DT Article
DE PCOS; Obesity; Hypertension; Cardiovascular disease; Cancer; Depression
ID CORONARY-ARTERY-DISEASE; OBSTRUCTIVE SLEEP-APNEA; ORAL-CONTRACEPTIVE
   USE; FOLLOW-UP; CARDIOVASCULAR-DISEASE; POSTMENOPAUSAL WOMEN;
   CARDIOMETABOLIC RISK; INSULIN-RESISTANCE; DIABETES-MELLITUS; PREVALENCE
AB Polycystic ovary syndrome (PCOS) is a common endocrine disorder with heterogenous clinical manifestations. The evidence indicates that PCOS is associated with long-term health risks including type 2 diabetes, metabolic syndrome, obstructive sleep apnea, endometrial cancer, and mood disorders. Although cardiometabolic risk factors are more common among women with PCOS, currently there is no strong evidence for increased cardiovascular morbidity and mortality in these patients. The effect of menopausal transition on the long-term health consequences of PCOS is mostly uncertain. The PCOS phenotype improves with aging in affected women. Accordingly, the differences in the cardiometabolic risk profiles of PCOS patients and of the general population seem to disappear after menopause. However, it is not clear whether this phenotype amelioration is associated with changes in other long-term health risks after the menopause. There are also gaps in our knowledge about the impact of long-term use of oral contraceptives on the prevalence of PCOS-related comorbidities. This review summarizes the current knowledge regarding the long-term health consequences of PCOS and their clinical implications in peri- and postmenopause, and highlights areas for future research.
C1 [Helvaci, Nafiye] Hitit Univ, Sch Med, Div Endocrinol & Metab, Corum, Turkey.
   [Yildiz, Bulent Okan] Hacettepe Univ, Sch Med, Div Endocrinol & Metab, Ankara, Turkey.
C3 Hitit University; Hacettepe University
RP Yildiz, BO (corresponding author), Hacettepe Univ, Sch Med, Dept Internal Med, Div Endocrinol & Metab, TR-06100 Ankara, Turkey.
EM yildizbo@yahoo.com
RI Yildiz, Bulent/ABD-7781-2020; Helvacı, Nafiye/GQQ-6956-2022
OI Yildiz, Bulent/0000-0003-1797-7662
CR Alsamarai S, 2009, J CLIN ENDOCR METAB, V94, P4961, DOI 10.1210/jc.2009-0839
   Amiri M, 2020, REPROD BIOL ENDOCRIN, V18, DOI 10.1186/s12958-020-00576-1
   Barry JA, 2014, HUM REPROD UPDATE, V20, P748, DOI 10.1093/humupd/dmu012
   Bozdag G, 2016, HUM REPROD, V31, P2841, DOI 10.1093/humrep/dew218
   Bromberger JT, 2011, OBSTET GYN CLIN N AM, V38, P609, DOI 10.1016/j.ogc.2011.05.011
   Brown ZA, 2011, FERTIL STERIL, V96, P1259, DOI 10.1016/j.fertnstert.2011.09.002
   Cancer Research UK, 2020, LIV CANC STAT
   Carmina E, 2012, OBSTET GYNECOL, V119, P263, DOI 10.1097/AOG.0b013e31823f7135
   Cassar S, 2016, HUM REPROD, V31, P2619, DOI 10.1093/humrep/dew243
   Chang J, 2004, FERTIL STERIL, V81, P19, DOI 10.1016/j.fertnstert.2003.10.004
   ChasanTaber L, 1997, DIABETES CARE, V20, P330, DOI 10.2337/diacare.20.3.330
   Cibula D, 2000, HUM REPROD, V15, P785, DOI 10.1093/humrep/15.4.785
   Cinar N, 2012, HUM REPROD, V27, P1840, DOI 10.1093/humrep/des113
   Cinar N, 2011, HUM REPROD, V26, P3339, DOI 10.1093/humrep/der338
   Cooney LG, 2017, HUM REPROD, V32, P1075, DOI 10.1093/humrep/dex044
   Davis SR, 2012, CLIMACTERIC, V15, P419, DOI 10.3109/13697137.2012.707385
   Davis SR, 2015, NAT REV DIS PRIMERS, V1, DOI 10.1038/nrdp.2015.4
   de Medeiros SF, 2018, INT J INFLAMM, V2018, DOI 10.1155/2018/9591509
   de Medeiros SF, 2017, REPROD BIOL ENDOCRIN, V15, DOI 10.1186/s12958-017-0313-y
   Dokras A, 2018, FERTIL STERIL, V109, P888, DOI 10.1016/j.fertnstert.2018.01.038
   Dumesic DA, 2013, STEROIDS, V78, P782, DOI 10.1016/j.steroids.2013.04.004
   Echiburú B, 2016, METABOLISM, V65, P776, DOI 10.1016/j.metabol.2016.01.006
   Forslund M, 2020, HUM REPROD OPEN, V2020, DOI 10.1093/hropen/hoz042
   Freeman EW, 2004, ARCH GEN PSYCHIAT, V61, P62, DOI 10.1001/archpsyc.61.1.62
   Gambineri A, 2012, DIABETES, V61, P2369, DOI 10.2337/db11-1360
   Gierisch JM, 2013, CANCER EPIDEM BIOMAR, V22, P1931, DOI 10.1158/1055-9965.EPI-13-0298
   Gottschau M, 2015, GYNECOL ONCOL, V136, P99, DOI 10.1016/j.ygyno.2014.11.012
   Grimbizis GF, 2010, BEST PRACT RES CL OB, V24, P29, DOI 10.1016/j.bpobgyn.2009.08.010
   Halperin IJ, 2011, HUM REPROD, V26, P191, DOI 10.1093/humrep/deq301
   Hannaford P.C., 2010, BMJ, V340, P695
   Hart R, 2015, J CLIN ENDOCR METAB, V100, P911, DOI 10.1210/jc.2014-3886
   Helena Teede, 2018, TECHNICAL REPORT INT
   Helena Teede, 2018, INT EVIDENCE BASED G
   Helvaci N, 2014, MINERVA ENDOCRINOL, V39, P175
   Helvaci N, 2020, EXPERT REV ENDOCRINO, V15, P29, DOI 10.1080/17446651.2020.1719067
   Helvaci N, 2017, ENDOCR CONNECT, V6, P437, DOI 10.1530/EC-17-0129
   Hung JH, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0097041
   Iftikhar S, 2012, NETH J MED, V70, P74
   Kahal H, 2020, SLEEP BREATH, V24, P339, DOI 10.1007/s11325-019-01835-1
   Kakoly NS, 2019, EXPERT REV ENDOCRINO, V14, P23, DOI 10.1080/17446651.2019.1556094
   Karjula S, 2017, J CLIN ENDOCR METAB, V102, P1861, DOI 10.1210/jc.2016-3863
   Kumarendran B, 2019, EUR J ENDOCRINOL, V180, P265, DOI 10.1530/EJE-18-0693
   Legro RS, 2001, AM J MED, V111, P607, DOI 10.1016/S0002-9343(01)00948-2
   Lim SS, 2019, OBES REV, V20, P339, DOI 10.1111/obr.12762
   Lim SS, 2012, HUM REPROD UPDATE, V18, P618, DOI 10.1093/humupd/dms030
   Lin TY, 2017, SLEEP MED, V36, P165, DOI 10.1016/j.sleep.2016.12.029
   Lindberg E, 2020, SLEEP MED REV, V49, DOI 10.1016/j.smrv.2019.101225
   Lizneva D, 2016, FERTIL STERIL, V106, P1510, DOI 10.1016/j.fertnstert.2016.07.1121
   Lizneva D, 2016, FERTIL STERIL, V106, P6, DOI 10.1016/j.fertnstert.2016.05.003
   Lunde O, 2007, GYNECOL ENDOCRINOL, V23, P704, DOI 10.1080/09513590701705189
   Merz CNB, 2006, FERTIL STERIL, V85, P1425, DOI 10.1016/j.fertnstert.2005.01.009
   Merz CNB, 2016, J WOMENS HEALTH, V25, P875, DOI 10.1089/jwh.2015.5441
   Meun C, 2020, CLIN ENDOCRINOL, V92, P150, DOI 10.1111/cen.14117
   Meun C, 2018, J CLIN ENDOCR METAB, V103, P1622, DOI 10.1210/jc.2017-02421
   Mumusoglu S., 2018, CURR VASC PHARM, P16
   Polotsky AJ, 2014, J CLIN ENDOCR METAB, V99, P2120, DOI 10.1210/jc.2013-4170
   Sam S, 2019, CLIN MED INSIGHTS-RE, V13, DOI 10.1177/1179558119871269
   Schmidt J, 2011, J CLIN ENDOCR METAB, V96, P3794, DOI 10.1210/jc.2011-1677
   Schmidt J, 2011, J CLIN ENDOCR METAB, V96, P2178, DOI 10.1210/jc.2010-2959
   Senaratna CV, 2017, SLEEP MED REV, V34, P70, DOI 10.1016/j.smrv.2016.07.002
   Shobeiri Fatemeh, 2016, Obstet Gynecol Sci, V59, P367, DOI 10.5468/ogs.2016.59.5.367
   Slopien R, 2018, MATURITAS, V117, P6, DOI 10.1016/j.maturitas.2018.08.009
   Soares CN, 2019, MED CLIN N AM, V103, P651, DOI 10.1016/j.mcna.2019.03.001
   Soares CN, 2014, MENOPAUSE, V21, P198, DOI 10.1097/GME.0000000000000193
   Tay CT, 2018, CLIN ENDOCRINOL, V89, P535, DOI 10.1111/cen.13753
   Tehrani FR, 2020, GYNECOL ENDOCRINOL, V36, P12, DOI 10.1080/09513590.2019.1650337
   Wild S, 2000, CLIN ENDOCRINOL, V52, P595, DOI 10.1046/j.1365-2265.2000.01000.x
   Wild Sarah, 2000, Hum Fertil (Camb), V3, P101, DOI 10.1080/1464727002000198781
   Yildiz BO, 2008, SEMIN REPROD MED, V26, P111, DOI 10.1055/s-2007-992931
   Yildiz BO, 2012, HUM REPROD, V27, P3067, DOI 10.1093/humrep/des232
   Young T, 2003, AM J RESP CRIT CARE, V167, P1181, DOI 10.1164/rccm.200209-1055OC
NR 71
TC 25
Z9 29
U1 1
U2 17
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD SEP
PY 2020
VL 139
BP 12
EP 19
DI 10.1016/j.maturitas.2020.05.013
PG 8
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA MW0UU
UT WOS:000556763600003
PM 32747035
DA 2025-06-11
ER

PT J
AU Sil, R
   Ray, D
   Chakraborti, AS
AF Sil, Rajarshi
   Ray, Doel
   Chakraborti, Abhay Sankar
TI Glycyrrhizin ameliorates insulin resistance, hyperglycemia, dyslipidemia
   and oxidative stress in fructose-induced metabolic syndrome-X in rat
   model
SO INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY
LA English
DT Article
DE Metabolic syndrome; High fructose diet; Glycation; Insulin resistance;
   Peroxisome proliferator activated receptor gamma; Glucose transporter 4
ID DIABETIC-RATS; 18-BETA-GLYCYRRHETINIC ACID; HEMOGLOBIN; GLYCATION;
   GLUCOSE; IRON; PEROXIDES; DISEASE; PLASMA; DAMAGE
AB This study investigates if glycyrrhizin, a constituent of licorice (Glycyrrhiza glabra) root, is able to treat the complications (insulin resistance, hyperglycemia, dyslipidemia and oxidative stress) of metabolic syndrome. Metabolic syndrome was induced in rats by feeding a fructose-enriched (60%) diet for six weeks, after which single dose of glycyrrhizin (50 mg/kg body weight) was administered intraperitoneally. Different biochemical parameters from blood were estimated during three weeks after treatment. Then the rats were sacrificed to collect skeletal muscle tissue. Glycyrrhizin reduced the enhanced levels of blood glucose, insulin and lipids in metabolic syndrome group. Increased advanced glycation end products of hemoglobin, glycohemoglobin, hemoglobin-mediated iron release and iron-mediated free radical reactions (arachidonic acid and deoxyribose degradation) in metabolic syndrome were inhibited by glycyrrhizin treatment. Reduced activities of enzymatic antioxidants (superoxide dismutase and catalase) and elevated oxidative stress markers (malonaldehyde, fructosamine, hemoglobin carbonyl content and DNA damage) in metabolic syndrome were reversed to almost normal levels by glycyrrhizin. The decreased levels of peroxisome proliferator activated receptor gamma (PPAR gamma) and glucose transporter 4 (GLUT4) proteins in skeletal muscle of metabolic syndrome group were elevated by glycyrrhizin, indicating improved fatty acid oxidation and glucose homeostasis.
C1 [Sil, Rajarshi; Ray, Doel; Chakraborti, Abhay Sankar] Univ Calcutta, Dept Biophys Mol Biol & Bioinformat, Univ Coll Sci, Kolkata 700009, India.
C3 University of Calcutta
RP Chakraborti, AS (corresponding author), Univ Calcutta, Dept Biophys Mol Biol & Bioinformat, Univ Coll Sci, 92 Acharyya Prafulla Chandra Rd, Kolkata 700009, India.
EM ascbmbg@caluniv.ac.in
FU University Grants Commission, New Delhi, India; Council of Scientific
   and Industrial Research, New Delhi, India [38(1129)/03/EMR-II]; UGC-DSA;
   DST-FIST programme of the department
FX RS gets a Fellowship from the University Grants Commission, New Delhi,
   India. A part of the study was supported by a grant from the Council of
   Scientific and Industrial Research, New Delhi, India [grant No.
   38(1129)/03/EMR-II]. Financial assistance from UGC-DSA and DST-FIST
   programme of the department is thankfully acknowledged.
CR AMADOR E, 1962, CLIN CHEM, V8, P343
   BEERS RF, 1952, J BIOL CHEM, V195, P133
   BERGER J, 1989, NATURE, V340, P70, DOI 10.1038/340070a0
   Bergmeyer WI, 1974, METHOD ENZYMAT AN, P507
   Bhattacharyya J, 1998, INT J BIOL MACROMOL, V23, P11, DOI 10.1016/S0141-8130(98)00006-3
   Collins A, 1997, ENVIRON MOL MUTAGEN, V30, P139, DOI 10.1002/(SICI)1098-2280(1997)30:2<139::AID-EM6>3.0.CO;2-I
   Dekker MJ, 2010, AM J PHYSIOL-ENDOC M, V299, pE685, DOI 10.1152/ajpendo.00283.2010
   Delbosc S, 2005, ATHEROSCLEROSIS, V179, P43, DOI 10.1016/j.atherosclerosis.2004.10.018
   DORAI DT, 1977, J NEUROCHEM, V29, P503, DOI 10.1111/j.1471-4159.1977.tb10699.x
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   ELLMAN GL, 1959, ARCH BIOCHEM BIOPHYS, V82, P70, DOI 10.1016/0003-9861(59)90090-6
   Eu CHA, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-81
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Gill H, 2005, AM J MED SCI, V330, P290, DOI 10.1097/00000441-200512000-00006
   Guo L, 2006, PHARMACOL THERAPEUT, V111, P145, DOI 10.1016/j.pharmthera.2005.10.009
   GUTTERIDGE JMC, 1986, FEBS LETT, V201, P291, DOI 10.1016/0014-5793(86)80626-3
   HALLIWELL B, 1990, METHOD ENZYMOL, V186, P1
   Isbrucker RA, 2006, REGUL TOXICOL PHARM, V46, P167, DOI 10.1016/j.yrtph.2006.06.002
   JOHNSON RN, 1983, CLIN CHIM ACTA, V127, P87, DOI 10.1016/0009-8981(83)90078-5
   Kalaiarasi P., 2011, Journal of Pharmacy Research, V4, P107
   Kalaiarasi P, 2009, EUR J PHARMACOL, V612, P93, DOI 10.1016/j.ejphar.2009.04.003
   Kalaiarasi P, 2009, EUR J PHARMACOL, V606, P269, DOI 10.1016/j.ejphar.2008.12.057
   Kar M, 2001, CURR SCI INDIA, V80, P770
   Kar Manoj, 1999, Indian Journal of Experimental Biology, V37, P190
   Kuhlmann J, 2003, DIABETES, V52, P138, DOI 10.2337/diabetes.52.1.138
   Lee YA, 2008, J AGR FOOD CHEM, V56, P7781, DOI 10.1021/jf800639m
   LEVINE RL, 1990, METHOD ENZYMOL, V186, P464
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   MARKLUND S, 1974, EUR J BIOCHEM, V47, P469
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Nandhini ATA, 2002, NUTR RES, V22, P343, DOI 10.1016/S0271-5317(01)00391-8
   Nyenwe EA, 2009, AM J MED SCI, V338, P190, DOI 10.1097/MAJ.0b013e3181a84bde
   PANTER SS, 1994, METHOD ENZYMOL, V231, P502
   REITMAN S, 1957, AM J CLIN PATHOL, V28, P56, DOI 10.1093/ajcp/28.1.56
   Roy M, 2008, LIFE SCI, V82, P1102, DOI 10.1016/j.lfs.2008.03.011
   SADRZADEH SMH, 1984, J BIOL CHEM, V259, P4354
   Sen S, 2005, BIOPHYS CHEM, V113, P289, DOI 10.1016/j.bpc.2004.05.005
   Sen S, 2011, J PHARM PHARMACOL, V63, P287, DOI 10.1111/j.2042-7158.2010.01217.x
   Shih CC, 2009, J ETHNOPHARMACOL, V123, P82, DOI 10.1016/j.jep.2009.02.039
   SINGH NP, 1988, EXP CELL RES, V175, P184, DOI 10.1016/0014-4827(88)90265-0
   Takii H, 2001, BIOL PHARM BULL, V24, P484, DOI 10.1248/bpb.24.484
   Trinder P., 1969, Journal of Clinical Pathology, V22, P158, DOI 10.1136/jcp.22.2.158
   Wu JT, 1998, J CLIN LAB ANAL, V10, P21
   YAGI K, 1987, CHEM PHYS LIPIDS, V45, P337, DOI 10.1016/0009-3084(87)90071-5
   YAMAMURA Y, 1995, BIOL PHARM BULL, V18, P337, DOI 10.1248/bpb.18.337
   Yin CY, 2010, PPAR RES, V2010, DOI 10.1155/2010/530265
   Zhai DS, 2007, PLANTA MED, V73, P128, DOI 10.1055/s-2006-957067
NR 47
TC 38
Z9 44
U1 0
U2 8
PU NATL INST SCIENCE COMMUNICATION-NISCAIR
PI NEW DELHI
PA DR K S KRISHNAN MARG, PUSA CAMPUS, NEW DELHI 110 012, INDIA
SN 0019-5189
EI 0975-1009
J9 INDIAN J EXP BIOL
JI Indian J. Exp. Biol.
PD FEB
PY 2013
VL 51
IS 2
BP 129
EP 138
PG 10
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA 089IH
UT WOS:000314903700004
PM 23923606
DA 2025-06-11
ER

PT J
AU Liukkonen, T
   Räsänen, P
   Jokelainen, J
   Leinonen, M
   Järvelin, MR
   Meyer-Rochow, VB
   Timonen, M
AF Liukkonen, T.
   Rasanen, P.
   Jokelainen, J.
   Leinonen, M.
   Jarvelin, M. -R.
   Meyer-Rochow, V. B.
   Timonen, M.
TI The association between anxiety and C-reactive protein (CRP) levels:
   Results from the Northern Finland 1966 Birth Cohort Study
SO EUROPEAN PSYCHIATRY
LA English
DT Article
DE Anxiety disorders; Unipolar depression; Epidemiology; Neuroendogrinology
ID CORONARY-HEART-DISEASE; POSTTRAUMATIC-STRESS-DISORDER; HOPKINS SYMPTOM
   CHECKLIST-25; ACUTE MYOCARDIAL-INFARCTION; ORAL-CONTRACEPTIVE USE; MAJOR
   DEPRESSION; INFLAMMATORY MARKERS; RISK-FACTORS; PHYSICAL-ACTIVITY;
   INTERFERON-ALPHA
AB Background. - Anxiety frequently accompanies low-grade inflammation-associated conditions like depression, insulin resistance, coronary heart disease and metabolic syndrome. The association between anxiety and low-grade inflammation is, unlike between depression and low-grade inflammation, a very sparsely studied area in general populations. The aim of the present study was to investigate whether anxiety symptoms as well as comorbid anxiety and depressive symptoms are associated with low-grade inflammation at population level.
   Methods. - The general population-based Northern Finland 1966 Birth Cohort was followed until age 31 (n = 2688 males and 2837 females), when the highly sensitive CRP concentrations were measured. Anxiety and depressive symptoms were defined by Hopkins Symptom Checklist-25 (HSCL-25).
   Results. - After adjusting for confounders, logistic regression analyses showed that anxiety symptoms alone increased the probability for elevated hs-CRP levels (>3.0 mg/L) in males over two-fold (2.19 Cl 95% 1.08-4.46), while comorbid anxiety and depressive symptoms caused a 1.7-fold (1.76 Cl 95% 1.13-2.74) increase in the probability for elevated hs-CRP levels (1.0-3.0 mg/L).
   Conclusions. - Our results support the hypothesis that anxiety as well as comorbid anxiety and depression can be associated with an increased risk for low-grade inflammation in males at population level. (C) 2011 Elsevier Masson SAS. All rights reserved.
C1 [Liukkonen, T.] Savonlinna Cent Hosp, Dept Psychiat, Savonlinna 57120, Finland.
   [Liukkonen, T.; Jokelainen, J.; Jarvelin, M. -R.; Timonen, M.] Univ Oulu, Inst Hlth Sci, Oulu 90014, Finland.
   [Rasanen, P.] Univ Oulu, Dept Psychiat, Oulu 90014, Finland.
   [Jokelainen, J.] Oulu Univ Hosp, Unit Gen Practice, Oys 90029, Finland.
   [Leinonen, M.] Inst Hlth & Welf, Child & Adolescent Hlth & Wellbeing Unit, Oulu 90101, Finland.
   [Jarvelin, M. -R.] Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Epidemiol & Publ Hlth, London W21 PG, England.
   [Jarvelin, M. -R.] Univ Oulu, Bioctr Oulu, Oulu 90014, Finland.
   [Jarvelin, M. -R.] Natl Inst Hlth & Welf, Lifecourse & Serv Dept, Oulu 90101, Finland.
   [Meyer-Rochow, V. B.] Univ Bremen, Sch Sci & Engn, D-28725 Bremen, Germany.
   [Meyer-Rochow, V. B.] Univ Oulu, Dept Physiol, Oulu 90014, Finland.
   [Timonen, M.] Oulu Hlth Ctr, Oulu 90015, Finland.
C3 University of Oulu; University of Oulu; University of Oulu; Imperial
   College London; University of Oulu; Finland National Institute for
   Health & Welfare; University of Bremen; University of Oulu
RP Liukkonen, T (corresponding author), Savonlinna Cent Hosp, Dept Psychiat, Keskussairaalantie 6, Savonlinna 57120, Finland.
EM timo.liukkonen@isshp.fi
RI MEYER-ROCHOW, Victor/AAJ-7258-2020
OI Jokelainen, Jari/0000-0003-4629-0560; MEYER-ROCHOW, V.
   Benno/0000-0003-1531-9244; Jarvelin, Marjo-Riitta/0000-0002-2149-0630
FU Finnish Cultural Foundation; Academy of Finland; Ministry of Health and
   Wellbeing; National Institute of Health; Oulu University Hospital;
   University of Oulu
FX This study was supported by the Finnish Cultural Foundation (Liukkonen),
   the Academy of Finland (Jarvelin), the Ministry of Health and Wellbeing
   (Jarvelin), the National Institute of Health (Jarvelin), Oulu University
   Hospital and the University of Oulu (Jarvelin).
CR Adamopoulos DA, 2002, MENOPAUSE, V9, P443, DOI 10.1097/00042192-200211000-00010
   Albert CM, 2005, CIRCULATION, V111, P480, DOI 10.1161/01.CIR.0000153813.64165.5D
   Aziz N, 2003, CLIN DIAGN LAB IMMUN, V10, P652, DOI 10.1128/CDLI.10.4.652-657.2003
   Baker DG, 2001, NEUROIMMUNOMODULAT, V9, P209, DOI 10.1159/000049028
   Bankier B, 2008, EUR HEART J, V29, P2212, DOI 10.1093/eurheartj/ehn326
   Bankier B, 2009, PSYCHOSOMATICS, V50, P347, DOI 10.1176/appi.psy.50.4.347
   Barger SD, 2005, J AFFECT DISORDERS, V88, P87, DOI 10.1016/j.jad.2005.05.012
   Boyle SH, 2006, PSYCHOSOM MED, V68, P844, DOI 10.1097/01.psy.0000240779.55022.ff
   Brennan AM, 2009, DIABETES CARE, V32, P926, DOI 10.2337/dc08-1979
   BRESLAU N, 1993, ARCH GEN PSYCHIAT, V50, P31
   Capuron L, 2004, BIOL PSYCHIAT, V56, P819, DOI 10.1016/j.biopsych.2004.02.009
   Carney RM, 2008, J AFFECT DISORDERS, V109, P133, DOI 10.1016/j.jad.2007.12.005
   Chae CU, 2001, HYPERTENSION, V38, P399, DOI 10.1161/01.HYP.38.3.399
   Danner M, 2003, PSYCHOSOM MED, V65, P347, DOI 10.1097/01.PSY.0000041542.29808.01
   Das UN, 2002, EXP BIOL MED, V227, P989, DOI 10.1177/153537020222701106
   DEROGATIS L R, 1973, Psychopharmacology Bulletin, V9, P13
   Dreon DM, 2003, LIFE SCI, V73, P1245, DOI 10.1016/S0024-3205(03)00425-9
   Empana JP, 2005, CIRCULATION, V111, P2299, DOI 10.1161/01.CIR.0000164203.54111.AE
   Evans DL, 2003, BIOL PSYCHIAT, V54, P177, DOI 10.1016/S0006-3223(03)00639-5
   Felger JC, 2007, BIOL PSYCHIAT, V62, P1324, DOI 10.1016/j.biopsych.2007.05.026
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Ford DE, 2004, ARCH INTERN MED, V164, P1010, DOI 10.1001/archinte.164.9.1010
   Frasure-Smith N, 2005, PSYCHOSOM MED, V67, pS19, DOI 10.1097/01.psy.0000162253.07959.db
   Freeman MP, 2001, JAMA-J AM MED ASSOC, V286, P671, DOI 10.1001/jama.286.6.671
   Gimeno D, 2009, PSYCHOL MED, V39, P413, DOI 10.1017/S0033291708003723
   Goodwin RD, 2003, PREV MED, V36, P698, DOI 10.1016/S0091-7435(03)00042-2
   Herrán A, 2005, INT J NEUROPSYCHOPH, V8, P529, DOI 10.1017/S1461145705005432
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Huffman JC, 2010, NEUROPSYCH DIS TREAT, V6, P123
   Huffman JC, 2008, J PSYCHOSOM RES, V65, P557, DOI 10.1016/j.jpsychores.2008.08.001
   Järvelin MR, 2004, HYPERTENSION, V44, P838, DOI 10.1161/01.HYP.0000148304.33869.ee
   Joffe H, 1998, BIOL PSYCHIAT, V44, P798, DOI 10.1016/S0006-3223(98)00169-3
   Katon WJ, 2003, BIOL PSYCHIAT, V54, P216, DOI 10.1016/S0006-3223(03)00273-7
   KESKIMAKI I, 1995, SOC SCI MED, V41, P425, DOI 10.1016/0277-9536(94)00339-U
   Koenig W, 1999, CIRCULATION, V99, P237, DOI 10.1161/01.CIR.99.2.237
   Kubzansky Laura D, 2009, Cleve Clin J Med, V76 Suppl 2, pS60, DOI 10.3949/ccjm.76.s2.12
   Kubzansky LD, 1998, ANN BEHAV MED, V20, P47, DOI 10.1007/BF02884448
   LACOVIDES A, 2008, CURR OPIN PSYCHIATR, V21, P417
   LADVIG KH, 2003, BRAIN BEHAV IMMUN, V17, P268
   LEHTINEN V, 1994, ACTA PSYCHIAT SCAND, V89, P7, DOI 10.1111/j.1600-0447.1994.tb05794.x
   Lett HS, 2004, PSYCHOSOM MED, V66, P305, DOI 10.1097/01.psy.0000126207.43307.c0
   Liukkonen T, 2006, BIOL PSYCHIAT, V60, P825, DOI 10.1016/j.biopsych.2006.02.016
   MAES M, 1995, PROG NEURO-PSYCHOPH, V19, P11, DOI 10.1016/0278-5846(94)00101-M
   Mantella RC, 2008, PSYCHONEUROENDOCRINO, V33, P773, DOI 10.1016/j.psyneuen.2008.03.002
   McLeish AC, 2009, J NERV MENT DIS, V197, P111, DOI 10.1097/NMD.0b013e3181961683
   Miller RJ, 2001, CYTOKINE, V13, P253, DOI 10.1006/cyto.2000.0825
   MOLLICA RF, 1987, AM J PSYCHIAT, V144, P497
   NETTELBLADT P, 1993, SOC PSYCH PSYCH EPID, V28, P130, DOI 10.1007/BF00801743
   Odgers CL, 2007, ARCH GEN PSYCHIAT, V64, P476, DOI 10.1001/archpsyc.64.4.476
   Otte Christian, 2008, Dialogues Clin Neurosci, V10, P453
   Paluska SA, 2000, SPORTS MED, V29, P167, DOI 10.2165/00007256-200029030-00003
   Parashar S, 2006, ARCH INTERN MED, V166, P2035, DOI 10.1001/archinte.166.18.2035
   Pariante CM, 2008, TRENDS NEUROSCI, V31, P464, DOI 10.1016/j.tins.2008.06.006
   PASCO JA, 2009, IFPE INT C VIENN APR
   Pearson TA, 2003, CIRCULATION, V107, P499, DOI 10.1161/01.CIR.0000052939.59093.45
   Penninx BWJH, 2003, BIOL PSYCHIAT, V54, P566, DOI 10.1016/S0006-3223(02)01811-5
   Pigott TA, 1999, J CLIN PSYCHIAT, V60, P4
   Pitsavos C, 2006, ATHEROSCLEROSIS, V185, P320, DOI 10.1016/j.atherosclerosis.2005.06.001
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Pratt LA, 1996, CIRCULATION, V94, P3123, DOI 10.1161/01.CIR.94.12.3123
   Rantakallio P, 1988, Paediatr Perinat Epidemiol, V2, P59, DOI 10.1111/j.1365-3016.1988.tb00180.x
   Rantakallio P., 1969, Acta Paediatr Scand, V193, P1
   Reichenberg A, 2001, ARCH GEN PSYCHIAT, V58, P445, DOI 10.1001/archpsyc.58.5.445
   Roberts RE, 2000, AM J EPIDEMIOL, V152, P163, DOI 10.1093/aje/152.2.163
   Rocca WA, 2008, MENOPAUSE, V15, P1050, DOI 10.1097/GME.0000000000001229
   ROY A, 1991, ARCH GEN PSYCHIAT, V48, P428
   Sandanger I, 1998, SOC PSYCH PSYCH EPID, V33, P345, DOI 10.1007/s001270050064
   Sillanaukee P, 2003, ALCOHOL CLIN EXP RES, V27, P57, DOI 10.1097/01.ALC.0000047302.67780.FA
   Solomon MB, 2009, PHYSIOL BEHAV, V97, P250, DOI 10.1016/j.physbeh.2009.02.033
   Söndergaard HP, 2004, CLIN CHIM ACTA, V342, P93, DOI 10.1016/j.cccn.2003.12.019
   Sorri M, 1998, Int J Circumpolar Health, V57, P82
   Sperner-Unterweger B, 2005, DRUGS, V65, P1493, DOI 10.2165/00003495-200565110-00004
   Stewart JC, 2009, BRAIN BEHAV IMMUN, V23, P936, DOI 10.1016/j.bbi.2009.04.011
   Taponen S, 2004, J CLIN ENDOCR METAB, V89, P2114, DOI 10.1210/jc.2003-031720
   Tzoulaki I, 2008, EUR HEART J, V29, P1049, DOI 10.1093/eurheartj/ehn105
   Veen G, 2009, EUR NEUROPSYCHOPHARM, V19, P409, DOI 10.1016/j.euroneuro.2009.02.007
   von Känel R, 2007, J PSYCHIATR RES, V41, P744, DOI 10.1016/j.jpsychires.2006.06.009
   Williams MJA, 2004, INT J OBESITY, V28, P998, DOI 10.1038/sj.ijo.0802713
   WINOKUR A, 1984, BRIT J PSYCHIAT, V144, P395, DOI 10.1192/bjp.144.4.395
NR 79
TC 106
Z9 115
U1 0
U2 21
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0924-9338
EI 1778-3585
J9 EUR PSYCHIAT
JI Eur. Psychiat.
PD SEP
PY 2011
VL 26
IS 6
BP 363
EP 369
DI 10.1016/j.eurpsy.2011.02.001
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 824GP
UT WOS:000295190700004
PM 21570260
DA 2025-06-11
ER

PT J
AU Minehira, K
   Tappy, L
AF Minehira, K
   Tappy, L
TI Dietary and lifestyle interventions in the management of the metabolic
   syndrome: present status and future perspective
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE insulin resistance; fat intake; intramyocellular lipid; free fatty acid;
   exercise
ID FREE FATTY-ACIDS; INSULIN-RESISTANCE; GLUCOSE-METABOLISM; MENTAL STRESS;
   HEALTHY-MEN; SENSITIVITY; MECHANISMS; DISEASE; MUSCLE; HYPERTENSION
AB Objective: To review the mechanisms underlying the metabolic syndrome, or syndrome X, in humans, and to delineate dietary and environmental strategies for its prevention.
   Design: Review of selected papers of the literature.
   Results: Hyperinsulinemia and insulin resistance play a key role in the development of the metabolic syndrome. Strategies aimed at reducing insulin resistance may be effective in improving the metabolic syndrome. They include low saturated fat intake, consumption of low-glycemic-index foods, physical exercise and prevention of obesity.
   Conclusions: Future research, in particular the genetic basis of the metabolic syndrome and the interorgan interactions responsible for insulin resistance, is needed to improve therapeutic strategies for the metabolic syndrome.
C1 Univ Lausanne, Inst Physiol, CH-1005 Lausanne, Switzerland.
C3 University of Lausanne
RP Univ Lausanne, Inst Physiol, 7 Rue Bugnon, CH-1005 Lausanne, Switzerland.
EM luc.tappy@iphysiol.unil.ch
RI Tappy, Luc/A-8911-2017
OI Tappy, Luc/0000-0001-8469-4692
CR Andersson A, 2000, AM J PHYSIOL-ENDOC M, V279, pE744, DOI 10.1152/ajpendo.2000.279.4.E744
   [Anonymous], 2000, Arch Intern Med, V160, P898
   Bailey CJ, 1996, NEW ENGL J MED, V334, P574, DOI 10.1056/NEJM199602293340906
   BARON AD, 1993, BAILLIERE CLIN ENDOC, V7, P961, DOI 10.1016/S0950-351X(05)80241-1
   Battilana P, 2001, EUR J CLIN NUTR, V55, P327, DOI 10.1038/sj.ejcn.1601160
   Battilana P, 2001, J CLIN ENDOCR METAB, V86, P124, DOI 10.1210/jc.86.1.124
   Björntorp P, 2000, INT J OBESITY, V24, pS80, DOI 10.1038/sj.ijo.0801285
   Blundell JE, 1996, ANNU REV NUTR, V16, P285, DOI 10.1146/annurev.nutr.16.1.285
   Borghouts LB, 2000, INT J SPORTS MED, V21, P1, DOI 10.1055/s-2000-8847
   CAMPBELL LV, 1994, DIABETES CARE, V17, P177, DOI 10.2337/diacare.17.3.177
   Chao L, 2000, J CLIN INVEST, V106, P1221, DOI 10.1172/JCI11245
   Day C, 1999, DIABETIC MED, V16, P179, DOI 10.1046/j.1464-5491.1999.00023.x
   DEFRONZO RA, 1991, DIABETES CARE, V14, P173, DOI 10.2337/diacare.14.3.173
   DEFRONZO RA, 1988, DIABETES, V37, P667, DOI 10.2337/diab.37.6.667
   Dobbins RL, 2001, DIABETES, V50, P123, DOI 10.2337/diabetes.50.1.123
   Dresner A, 1999, J CLIN INVEST, V103, P253, DOI 10.1172/JCI5001
   Ellis BA, 2000, AM J PHYSIOL-ENDOC M, V279, pE554, DOI 10.1152/ajpendo.2000.279.3.E554
   FELBER JP, 1992, OBESITY DIABETES
   Golan M, 1998, INT J OBESITY, V22, P1217, DOI 10.1038/sj.ijo.0800749
   HOLLENBECK CB, 1993, AM J CLIN NUTR, V58, P800
   Kelley David E., 1997, P57
   Kersten S, 2000, NATURE, V405, P421, DOI 10.1038/35013000
   Krssak M, 1999, DIABETOLOGIA, V42, P113, DOI 10.1007/s001250051123
   Kubota N, 1999, MOL CELL, V4, P597, DOI 10.1016/S1097-2765(00)80210-5
   Marshall JA, 1997, DIABETOLOGIA, V40, P430, DOI 10.1007/s001250050697
   Parks EJ, 2000, AM J CLIN NUTR, V71, P412
   RANDLE PJ, 1963, LANCET, V1, P785
   RAVUSSIN E, 1999, INT J OBES RELAT MET, V23, P47
   REAVEN GM, 1991, DIABETES CARE, V14, P195, DOI 10.2337/diacare.14.3.195
   Reaven GM, 1996, NEW ENGL J MED, V334, P374, DOI 10.1056/NEJM199602083340607
   Reaven GM, 1999, ANN NY ACAD SCI, V892, P45, DOI 10.1111/j.1749-6632.1999.tb07784.x
   Reaven GM, 1997, CURR OPIN LIPIDOL, V8, P23, DOI 10.1097/00041433-199702000-00006
   Reitman ML, 1999, ANN NY ACAD SCI, V892, P289, DOI 10.1111/j.1749-6632.1999.tb07802.x
   RICCARDI G, 1991, DIABETES CARE, V14, P1115, DOI 10.2337/diacare.14.12.1115
   Riccardi G, 2000, BRIT J NUTR, V83, pS143
   Ruderman NB, 1999, AM J PHYSIOL-ENDOC M, V276, pE1, DOI 10.1152/ajpendo.1999.276.1.E1
   Sakul H, 1997, AM J HUM GENET, V60, P651
   Seematter G, 2000, AM J PHYSIOL-ENDOC M, V279, pE799, DOI 10.1152/ajpendo.2000.279.4.E799
   SHIMADA M, 2000, GEOMECH RES SER, V2, P1
   Shulman GI, 2000, J CLIN INVEST, V106, P171, DOI 10.1172/JCI10583
   Steinberg HO, 1997, J CLIN INVEST, V100, P1230, DOI 10.1172/JCI119636
   TAPPY L, 1991, DIABETES CARE, V14, P1180, DOI 10.2337/diacare.14.12.1180
   Vessby B, 2001, DIABETOLOGIA, V44, P312, DOI 10.1007/s001250051620
   Winder WW, 1999, AM J PHYSIOL-ENDOC M, V277, pE1, DOI 10.1152/ajpendo.1999.277.1.E1
NR 44
TC 22
Z9 26
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0954-3007
EI 1476-5640
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD DEC
PY 2002
VL 56
IS 12
DI 10.1038/sj.ejcn.1601645
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 638LL
UT WOS:000180572400012
DA 2025-06-11
ER

PT J
AU Philip, J
   Ryman, TK
   Hopkins, SE
   O'Brien, DM
   Bersamin, A
   Pomeroy, J
   Thummel, KE
   Austin, MA
   Boyer, BB
   Dombrowski, K
AF Philip, Jacques
   Ryman, Tove K.
   Hopkins, Scarlett E.
   O'Brien, Diane M.
   Bersamin, Andrea
   Pomeroy, Jeremy
   Thummel, Kenneth E.
   Austin, Melissa A.
   Boyer, Bert B.
   Dombrowski, Kirk
TI Bi-cultural dynamics for risk and protective factors for cardiometabolic
   health in an Alaska Native (Yup'ik) population
SO PLOS ONE
LA English
DT Article
ID DENSITY-LIPOPROTEIN CHOLESTEROL; YUKON-KUSKOKWIM DELTA; MARINE
   FOOD-INTAKE; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; BLOOD-PRESSURE;
   MENTAL-HEALTH; INUIT YOUTH; EICOSAPENTAENOIC ACID; DOCOSAHEXAENOIC ACID
AB Alaska Native people experience disparities in mortality from heart disease and stroke. This work attempts to better understand the relationships between socioeconomic, behavioral, and cardiometabolic risk factors among Yup'ik people of southwestern Alaska, with a focus on the role of the socioeconomic, and cultural components. Using a cross-sectional sample of 486 Yup'ik adults, we fitted a Partial Least Squares Path Model (PLS-PM) to assess the associations between components, including demographic factors [age and gender], socioeconomic factors [education, economic status, Yup'ik culture, and Western culture], behavioral factors [diet, cigarette smoking and smokeless tobacco use, and physical activity], and cardiometabolic risk factors [adiposity, triglyceride-HDL and LDL lipids, glycemia, and blood pressure]. We found relatively mild associations of education and economic status with cardiometabolic risk factors, in contrast with studies in other populations. The socioeconomic factor and participation in Yup'ik culture had potentially protective associations with adiposity, triglyceride-HDL lipids, and blood pressure, whereas participation in Western culture had a protective association with blood pressure. We also found a moderating effect of participation in Western culture on the relationships between Yup'ik culture participation and both blood pressure and LDL lipids, indicating a potentially beneficial additional effect of biculturalism. Our results suggest that reinforcing protective effects of both Yup'ik and Western cultures could be useful for interventions aimed at reducing cardiometabolic health disparities.
C1 [Philip, Jacques; Hopkins, Scarlett E.; O'Brien, Diane M.; Bersamin, Andrea; Boyer, Bert B.] Univ Alaska Fairbanks, Ctr Alaska Native Hlth Res, Fairbanks, AK 99775 USA.
   [Ryman, Tove K.] Bill & Melinda Gates Fdn, Seattle, WA USA.
   [Pomeroy, Jeremy] Marshfield Clin Fdn Med Res & Educ, Res Inst, Marshfield, WI USA.
   [Thummel, Kenneth E.] Univ Washington, Dept Pharmaceut, Seattle, WA 98195 USA.
   [Austin, Melissa A.] Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.
   [Dombrowski, Kirk] Univ Nebraska, Dept Sociol, Lincoln, NE 68588 USA.
C3 University of Alaska System; University of Alaska Fairbanks; Bill &
   Melinda Gates Foundation; Marshfield Clinic; University of Washington;
   University of Washington Seattle; University of Washington; University
   of Washington Seattle; University of Nebraska System; University of
   Nebraska Lincoln
RP Philip, J (corresponding author), Univ Alaska Fairbanks, Ctr Alaska Native Hlth Res, Fairbanks, AK 99775 USA.
EM jphilip@alaska.edu
RI O'Brien, Diane/B-2919-2010
FU National Institute of Health [P20RR016430, P30GM103325, R01DK074842,
   U01GM092676, U54GM115371, U54GM104944]
FX The study was funded by the following grants from the National Institute
   of Health: P20RR016430, P30GM103325, R01DK074842, U01GM092676,
   U54GM115371, U54GM104944.
CR Abel T, 2012, SOC SCI MED, V74, P236, DOI 10.1016/j.socscimed.2011.10.028
   Albert MA, 2006, CIRCULATION, V114, P2619, DOI 10.1161/CIRCULATIONAHA.106.660043
   Allen J, 2014, AM J COMMUN PSYCHOL, V54, P100, DOI 10.1007/s10464-014-9647-1
   [Anonymous], MIS Q
   [Anonymous], AGING MENT HLTH
   [Anonymous], YOUTH VIOLENCE JUV J
   [Anonymous], 2003, MONOGR SOC RES CHILD
   [Anonymous], INT J CIRCUMPOLAR HL
   [Anonymous], AM J PUBLIC HLTH
   [Anonymous], 2008, J EPIDEMIOL COMMUN H, DOI DOI 10.1136/jech.2007.066159
   [Anonymous], ALASKA NATIVE KNOWLE
   [Anonymous], 2013, R PACKAGE NOTES
   [Anonymous], ETHN HLTH
   [Anonymous], 2016, American FactFinder
   [Anonymous], TRANSCULT PSYCHIAT
   [Anonymous], INT J CIRCUMPOLAR HL
   [Anonymous], AM J COMMUNITY PSYCH
   Ayunerak Paula, 2014, Am J Community Psychol, V54, P91, DOI 10.1007/s10464-014-9652-4
   Bauer KW, 2012, AM J PUBLIC HEALTH, V102, P1346, DOI 10.2105/AJPH.2011.300522
   Beaulieu-Jones BR, 2015, J NUTR, V145, P931, DOI 10.3945/jn.114.209619
   Berger ThomasR., 1985, VILLAGE JOURNEY REPO
   Bersamin A, 2014, ETHNIC HEALTH, V19, P255, DOI 10.1080/13557858.2012.758691
   Boden-Albala B, 2013, ETHNIC DIS, V23, P484
   Boyer BB, 2007, OBESITY, V15, P2535, DOI 10.1038/oby.2007.302
   Brabec M, 2007, AM J HUM BIOL, V19, P459, DOI 10.1002/ajhb.20606
   Brice-Bennett Carol., 1994, Dispossessed: The Eviction of Inuit from Hebron, Labrador
   BurnSilver S, 2016, AM ANTHROPOL, V118, P121, DOI 10.1111/aman.12447
   Cheadle JE, 2011, J HEALTH SOC BEHAV, V52, P228, DOI 10.1177/0022146510393973
   Chen D, 2017, REV PANAM SALUD PUBL, V41
   Currie CL, 2013, SOC SCI MED, V88, P1, DOI 10.1016/j.socscimed.2013.03.032
   Dombrowski K., 2013, Journal of Anthropology, V2013, P1, DOI DOI 10.1155/2013/185048
   Dombrowski K, 2014, IDENTITIES-GLOB STUD, V21, P134, DOI 10.1080/1070289X.2013.854718
   Dombrowski K, 2013, ARCTIC ANTHROPOL, V50, P89, DOI 10.3368/aa.50.1.89
   Dombrowski Kirk., 2014, CULTURE POLITICS STO
   Douglas Vasiliki., 2013, Introduction to Aboriginal Health and Health Care in Canada: Bridging Health and Healing
   Dressler WW, 2000, AM ANTHROPOL, V102, P244, DOI 10.1525/aa.2000.102.2.244
   Duran E., 1995, Native American postcolonial psychology, DOI DOI 10.13140/RG.2.2.25055.25769
   Edwards KL, 1998, AM J EPIDEMIOL, V147, P441, DOI 10.1093/oxfordjournals.aje.a009469
   Espey DK, 2014, AM J PUBLIC HEALTH, V104, pS303, DOI 10.2105/AJPH.2013.301798
   Fraser SL, 2015, SUICIDE LIFE-THREAT, V45, P141, DOI 10.1111/sltb.12122
   Garroutte EM, 2003, SOC SCI MED, V56, P1571, DOI 10.1016/S0277-9536(02)00157-0
   GERHARD GT, 1991, AM J CLIN NUTR, V54, P334, DOI 10.1093/ajcn/54.2.334
   Gone JP, 2007, AM J COMMUN PSYCHOL, V40, P290, DOI 10.1007/s10464-007-9136-x
   Gone JP, 2012, ANNU REV CLIN PSYCHO, V8, P131, DOI 10.1146/annurev-clinpsy-032511-143127
   Gone JP, 2011, J PSYCHOACTIVE DRUGS, V43, P291, DOI 10.1080/02791072.2011.628915
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Hallett D, 2007, COGNITIVE DEV, V22, P392, DOI 10.1016/j.cogdev.2007.02.001
   Hanson RL, 2002, DIABETES, V51, P3120, DOI 10.2337/diabetes.51.10.3120
   Henseler J, 2012, ELGAR ORIG REF, P252
   Jacobson TA, 2012, J CLIN LIPIDOL, V6, P5, DOI 10.1016/j.jacl.2011.10.018
   Jernigan VBB, 2017, AM J PUBLIC HEALTH, V107, P441, DOI 10.2105/AJPH.2016.303605
   Jernigan VBB, 2015, AM J PUBLIC HEALTH, V105, pS376, DOI 10.2105/AJPH.2014.302447
   Joe JR, 2014, AM INDIAN CULT RES J, V38, P123, DOI 10.17953/aicr.38.1.qj47130n435njl34
   Joe JR, 2014, AM INDIAN CULT RES J, V38, P11, DOI 10.17953/aicr.38.1.w753453k6h67061m
   Jorgensen ME, 2006, EUR J EPIDEMIOL, V21, P741, DOI 10.1007/s10654-006-9063-4
   Kaholokula JK, 2008, DIABETES CARE, V31, P698, DOI 10.2337/dc07-1560
   Kaufman CE, 2013, J CONSULT CLIN PSYCH, V81, P1040, DOI 10.1037/a0034342
   Kawagley AO, 1998, J RES SCI TEACH, V35, P133, DOI 10.1002/(SICI)1098-2736(199802)35:2<133::AID-TEA4>3.3.CO;2-C
   King M, 2009, LANCET, V374, P76, DOI 10.1016/S0140-6736(09)60827-8
   Kirmayer LJ, 1998, CAN J PSYCHIAT, V43, P816, DOI 10.1177/070674379804300806
   Kirmeyer L., 2003, Australian Psychiatry, V11, P15, DOI DOI 10.1046/J.1038-5282.2003.02010.X
   Koller KR, 2015, DIABETES RES CLIN PR, V108, P423, DOI 10.1016/j.diabres.2015.03.001
   Lara M, 2005, ANNU REV PUBL HEALTH, V26, P367, DOI 10.1146/annurev.publhealth.26.021304.144615
   Larimore J.A., 2005, NEW DIRECTIONS STUDE, V109th, P17, DOI [DOI 10.1002/SS.150, 10.1002/ss.150]
   Lazrus H, 2015, HUM ORGAN, V74, P52, DOI 10.17730/humo.74.1.q0667716284749m8
   Lehti V, 2009, SOC SCI MED, V69, P1194, DOI 10.1016/j.socscimed.2009.07.045
   MacDonald JP, 2015, SOC SCI MED, V141, P133, DOI 10.1016/j.socscimed.2015.07.017
   McIntosh CN, 2014, ORGAN RES METHODS, V17, P210, DOI 10.1177/1094428114529165
   McIvor O, 2009, INT J INDIG HEALTH, V5, P6
   Mendelsohn ME, 2002, AM J CARDIOL, V89, p12E
   Mensah GA, 2005, CIRCULATION, V111, P1233, DOI 10.1161/01.CIR.0000158136.76824.04
   Mitchell FM, 2012, HEALTH SOC WORK, V37, P71, DOI 10.1093/hsw/hls013
   Mitrou F, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-201
   Mohatt GV, 2007, INT J CIRCUMPOL HEAL, V66, P8, DOI 10.3402/ijch.v66i1.18219
   Moore K, 2014, AM J PUBLIC HEALTH, V104, pE158, DOI 10.2105/AJPH.2014.302108
   Morgan Mary S., 1992, The History of Econometric Ideas
   Moses J, 2017, HUM ORGAN, V76, P171, DOI 10.17730/0018-7259.76.2.171
   Nash SH, 2012, J NUTR, V142, P84, DOI 10.3945/jn.111.147595
   O'Brien DM, 2017, PUBLIC HEALTH NUTR, V20, P1738, DOI 10.1017/S1368980016001853
   O'Brien DM, 2014, J NUTR, V144, P706, DOI 10.3945/jn.113.189381
   O'Brien DM, 2009, AM J CLIN NUTR, V89, P913, DOI 10.3945/ajcn.2008.27054
   OETTING ER, 1991, INT J ADDICT, V25, P655, DOI 10.3109/10826089109077265
   Omran AR, 2005, MILBANK Q, V83, P731, DOI 10.1111/j.1468-0009.2005.00398.x
   ONell TD, 1996, SOC SCI MED, V42, P565, DOI 10.1016/0277-9536(95)00157-3
   Pappas RS, 2008, J ANAL TOXICOL, V32, P281, DOI 10.1093/jat/32.4.281
   Parlee Brenda, 2005, EcoHealth, V2, P127, DOI 10.1007/s10393-005-3870-z
   Philip J, 2016, PSYCHOSOC INTERV, V25, P45, DOI 10.1016/j.psi.2015.08.002
   Piano MR, 2010, CIRCULATION, V122, P1520, DOI 10.1161/CIR.0b013e3181f432c3
   Raats M. M., 1992, Food Quality and Preference, V3, P89, DOI 10.1016/0950-3293(91)90028-D
   Rasmus SM, 2014, AM J COMMUN PSYCHOL, V54, P140, DOI 10.1007/s10464-014-9651-5
   Reeve R, 2014, AUST NZ J PUBL HEAL, V38, P459, DOI 10.1111/1753-6405.12211
   Renner CC, 2005, AM J HEALTH BEHAV, V29, P588, DOI 10.5993/AJHB.29.6.13
   Ryman TK, 2015, NUTR METAB CARDIOVAS, V25, P1140, DOI 10.1016/j.numecd.2015.08.003
   Ryman TK, 2015, BRIT J NUTR, V113, P634, DOI 10.1017/S0007114514003596
   Ryman TK, 2014, PUBLIC HEALTH NUTR, V17, P510, DOI 10.1017/S1368980012005411
   Sider G., 2014, Skin for Skin: Death and Life for Innuit and Innu
   Silviken A, 2007, J ADOLESCENCE, V30, P613, DOI 10.1016/j.adolescence.2006.06.004
   Singer MK, 2012, PREV MED, V55, P356, DOI 10.1016/j.ypmed.2012.02.011
   Spicer P, 2001, SOC SCI MED, V53, P227, DOI 10.1016/S0277-9536(00)00333-6
   Steptoe A, 2013, ANNU REV PUBL HEALTH, V34, P337, DOI 10.1146/annurev-publhealth-031912-114452
   Stone RAT, 2006, J STUD ALCOHOL, V67, P236, DOI 10.15288/jsa.2006.67.236
   Sutton Peter., 2011, POLITICS SUFFERING I
   Tenenhaus M, 2005, COMPUT STAT DATA AN, V48, P159, DOI 10.1016/j.csda.2004.03.005
   Tester FrankJames Peter Kulchyski., 1994, Tammarniit (Mistakes): Inuit Relocation in the Eastern Arctic, 1939-63
   Valeggia CR, 2015, ANNU REV ANTHROPOL, V44, P117, DOI 10.1146/annurev-anthro-102214-013831
   Veenstra G, 2014, SOCIOL HLTH ILLN MON, P31
   Veenstra G, 2015, INT J EQUITY HEALTH, V14, DOI 10.1186/s12939-015-0167-x
   Vinzi E.V., 2010, HDB PARTIAL LEAST SQ, DOI [10.1007/978-3-540-32827-8, DOI 10.1007/978-3-540-32827-829]
   Wexler L, 2013, HEALTH PROMOT PRACT, V14, P617, DOI 10.1177/1524839912462390
   Wexler LM, 2006, SOC SCI MED, V63, P2938, DOI 10.1016/j.socscimed.2006.07.022
   Whitbeck LB, 2009, COMMUNITY MENT HLT J, V45, P62, DOI 10.1007/s10597-008-9172-5
   Wijndaele K, 2006, DIABETES CARE, V29, P2329, DOI 10.2337/dc06-1341
   Williams MV, 1998, ARCH INTERN MED, V158, P166, DOI 10.1001/archinte.158.2.166
   Wolsko C, 2007, INT J CIRCUMPOL HEAL, V66, P51, DOI 10.3402/ijch.v66i1.18226
   Wolsko C, 2006, ETHNIC HEALTH, V11, P345, DOI 10.1080/13557850600824005
   Wolsko C, 2009, CULT DIVERS ETHN MIN, V15, P165, DOI 10.1037/a0015323
   Zimmet P., 2005, Diabetes Voice, V50, P31
NR 117
TC 6
Z9 6
U1 0
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 1
PY 2017
VL 12
IS 11
AR e018345
DI 10.1371/journal.pone.0183451
PG 24
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA FL4VN
UT WOS:000414229700001
PM 29091709
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ware, WR
AF Ware, William R.
TI Psychological stress, insulin resistance, inflammation and the
   assessment of heart disease risk. Time for a paradigm shift?
SO MEDICAL HYPOTHESES
LA English
DT Article
ID CORONARY-ARTERY CALCIFICATION; C-REACTIVE PROTEIN; DENSITY-LIPOPROTEIN
   CHOLESTEROL; ELECTRON-BEAM TOMOGRAPHY; DIURNAL CORTISOL DECLINE;
   CARDIOVASCULAR-DISEASE; PRIMARY PREVENTION; METABOLIC SYNDROME;
   MYOCARDIAL-INFARCTION; AORTIC CALCIFICATION
AB There is growing evidence that the present risk assessment protocol for coronary heart disease appears to underestimate the risk in general and the presence and progression of atherosclerosis in particular. Little or no correlation has been found between the 10-year risk based on the Framingham model and the extent or progression of coronary calcification. In addition, a number of studies find the protocol based on current guidelines leads to an under appreciation of the risk of symptomatic coronary heart disease or the associated fatal and non-fatal events, especially in younger asymptomatic individuals and women. Furthermore, the current guidelines give secondary importance to insulin resistance and inflammation and do not include psychosocial stress and depression, both of which are established and important risk factors for coronary heart disease. An alternative approach to risk assessment is proposed which emphasizes insulin resistance and psychological stress and depression and gives much greater recognition to inflammation as a root cause and target for intervention than is found in current guidelines. Consistent with this view, a revised assessment protocol is suggested which is still appropriate to the primary care setting and which might provide a different and perhaps more effective and relevant approach to primary prevention and risk reduction. (c) 2008 Elsevier Ltd. All rights reserved.
C1 Univ Western Ontario, Fac Sci Emeritus, London, ON, Canada.
C3 Western University (University of Western Ontario)
RP Ware, WR (corresponding author), Univ Western Ontario, Fac Sci Emeritus, London, ON, Canada.
EM warewr@rogers.com
CR Abraham Jacob, 2007, J Cardiometab Syndr, V2, P119, DOI 10.1111/j.1559-4564.2007.05950.x
   Achenbach S, 2003, AM J CARDIOL, V92, P1471, DOI 10.1016/j.amjcard.2003.08.064
   Agatisa PIK, 2005, ARCH INTERN MED, V165, P1229, DOI 10.1001/archinte.165.11.1229
   Akosah KO, 2003, J AM COLL CARDIOL, V41, P1475, DOI 10.1016/S0735-1097(03)00187-6
   Albert CM, 2002, CIRCULATION, V105, P2595, DOI 10.1161/01.CIR.0000017493.03108.1C
   Albert CM, 2003, CIRCULATION, V107, P2096, DOI 10.1161/01.CIR.0000065223.21530.11
   Allison MA, 2005, INT J CARDIOL, V98, P325, DOI 10.1016/j.ijcard.2004.03.015
   Bays HE, 2007, AM J CARDIOL, V99, p35C, DOI 10.1016/j.amjcard.2006.11.020
   Beaglehole R, 2002, INT J EPIDEMIOL, V31, P1117, DOI 10.1093/ije/31.6.1117
   Berry JD, 2007, AM HEART J, V154, P80, DOI 10.1016/j.ahj.2007.03.042
   Black PH, 2006, MED HYPOTHESES, V67, P879, DOI 10.1016/j.mehy.2006.04.008
   Black PH, 2003, BRAIN BEHAV IMMUN, V17, P350, DOI 10.1016/S0889-1591(03)00048-5
   Black PH, 2002, J PSYCHOSOM RES, V52, P1, DOI 10.1016/S0022-3999(01)00302-6
   Brotman DJ, 2007, LANCET, V370, P1089, DOI 10.1016/S0140-6736(07)61305-1
   Brotman DJ, 2005, ARCH INTERN MED, V165, P138, DOI 10.1001/archinte.165.2.138
   Canoy D, 2007, CIRCULATION, V116, P2933, DOI 10.1161/CIRCULATIONAHA.106.673756
   Chen H, 2005, DIABETES, V54, P1914, DOI 10.2337/diabetes.54.7.1914
   Chironi G, 2002, ANGIOLOGY, V53, P677, DOI 10.1177/000331970205300608
   Chiuve SE, 2006, CIRCULATION, V114, P160, DOI 10.1161/CIRCULATIONAHA.106.621417
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cobb FR, 2003, AM HEART J, V146, P572, DOI 10.1016/S0002-8703(03)00500-3
   Cohen S, 2006, PSYCHOSOM MED, V68, P41, DOI 10.1097/01.psy.0000195967.51768.ea
   Cohn JN, 2003, AM HEART J, V146, P679, DOI 10.1016/S0002-8703(03)00499-x
   de Koning L, 2007, EUR HEART J, V28, P850, DOI 10.1093/eurheartj/ehm026
   de Lorgeril M, 2006, NUTR METAB CARDIOVAS, V16, P387, DOI 10.1016/j.numecd.2006.05.004
   Desai MY, 2004, AM HEART J, V148, P871, DOI 10.1016/j.ahj.2004.05.033
   Emberson JR, 2004, INT J EPIDEMIOL, V33, P289, DOI 10.1093/ije/dyh006
   Everson SA, 1997, BRIT MED J, V314, P553, DOI 10.1136/bmj.314.7080.553
   Greenland P, 2003, JAMA-J AM MED ASSOC, V290, P891, DOI 10.1001/jama.290.7.891
   Harris WS, 2007, PHARMACOL RES, V55, P217, DOI 10.1016/j.phrs.2007.01.013
   Hecht HS, 2001, AM J CARDIOL, V87, P406, DOI 10.1016/S0002-9149(00)01392-8
   Hemingway H, 1999, BMJ-BRIT MED J, V318, P1460, DOI 10.1136/bmj.318.7196.1460
   Hoff JA, 2003, ANN EPIDEMIOL, V13, P163, DOI 10.1016/S1047-2797(02)00277-6
   Houslay ES, 2006, HEART, V92, P1207, DOI 10.1136/hrt.2005.080929
   Hu GZ, 2005, EUR J CARDIOV PREV R, V12, P459, DOI 10.1097/01.hjr.0000173109.14228.71
   Iribarren C, 2000, JAMA-J AM MED ASSOC, V283, P2546, DOI 10.1001/jama.283.19.2546
   Jacobson Terry A, 2007, Curr Atheroscler Rep, V9, P145, DOI 10.1007/s11883-007-0011-x
   Jeppesen J, 2001, ARCH INTERN MED, V161, P361, DOI 10.1001/archinte.161.3.361
   Khot UN, 2003, JAMA-J AM MED ASSOC, V290, P898, DOI 10.1001/jama.290.7.898
   Klein S, 2007, DIABETES CARE, V30, P1647, DOI 10.2337/dc07-9921
   Koh KB, 2003, YONSEI MED J, V44, P793, DOI 10.3349/ymj.2003.44.5.793
   Kop WJ, 2005, PSYCHOSOM MED, V67, P343, DOI 10.1097/01.psy.0000161201.45643.8d
   Kronmal RA, 2007, CIRCULATION, V115, P2722, DOI 10.1161/CIRCULATIONAHA.106.674143
   Lakoski SG, 2007, ARCH INTERN MED, V167, P2437, DOI 10.1001/archinte.167.22.2437
   Landé KE, 1936, ARCH PATHOL, V22, P301
   Lemieux I, 2000, CIRCULATION, V102, P179, DOI 10.1161/01.CIR.102.2.179
   Libby P, 2002, CIRCULATION, V105, P1135, DOI 10.1161/hc0902.104353
   MATHUR KS, 1961, CIRCULATION, V23, P847, DOI 10.1161/01.CIR.23.6.847
   Matthews K, 2006, PSYCHOSOM MED, V68, P657, DOI 10.1097/01.psy.0000244071.42939.0e
   Matthews KA, 2006, PSYCHOSOM MED, V68, P355, DOI 10.1097/01.psy.0000221274.21709.d0
   McBride PE, 2007, JAMA-J AM MED ASSOC, V298, P336, DOI 10.1001/jama.298.3.336
   Mensah GA, 2005, AM J PREV MED, V29, P68, DOI 10.1016/j.amepre.2005.07.030
   Michos ED, 2005, AM HEART J, V150, P1276, DOI 10.1016/j.ahj.2005.02.037
   Naghavi M., 2006, AM J CARDIOL, V98, P2
   Nasir K, 2006, INT J CARDIOL, V108, P68, DOI 10.1016/j.ijcard.2005.04.008
   Nijm J, 2007, J INTERN MED, V262, P375, DOI 10.1111/j.1365-2796.2007.01817.x
   O'Malley PG, 2000, NEW ENGL J MED, V343, P1298, DOI 10.1056/NEJM200011023431803
   Oei HHS, 2004, EUR HEART J, V25, P48, DOI 10.1016/j.ehj.2003.10.008
   PATERSON JC, 1963, CIRCULATION, V27, P229, DOI 10.1161/01.CIR.27.2.229
   Pedersen HS, 2003, ATHEROSCLEROSIS, V170, P93, DOI 10.1016/S0021-9150(03)00240-5
   Ravnskov U, 2002, QJM-INT J MED, V95, P397, DOI 10.1093/qjmed/95.6.397
   Reaven G, 2004, RECENT PROG HORM RES, V59, P207, DOI 10.1210/rp.59.1.207
   Reaven GM, 2006, AM J CLIN NUTR, V83, P1237, DOI 10.1093/ajcn/83.6.1237
   Reaven GM, 2005, CLIN CHEM, V51, P931, DOI 10.1373/clinchem.2005.048611
   Reaven GM, 2003, J CLIN ENDOCR METAB, V88, P2399, DOI 10.1210/jc.2003-030087
   Rewers M, 2004, DIABETES CARE, V27, P781, DOI 10.2337/diacare.27.3.781
   Ridker PM, 2007, J AM COLL CARDIOL, V49, P2129, DOI 10.1016/j.jacc.2007.02.052
   Ridker PM, 2004, CIRCULATION, V109, P2818, DOI 10.1161/01.CIR.0000132467.45278.59
   Ridker PM, 2003, CIRCULATION, V108, P2292, DOI 10.1161/01.CIR.0000100688.17280.E6
   Ridker PM, 2002, NEW ENGL J MED, V347, P1557, DOI 10.1056/NEJMoa021993
   ROOT M, 2004, JAMA-J AM MED ASSOC, V291, P291
   Rosmond R, 2000, J INTERN MED, V247, P188, DOI 10.1046/j.1365-2796.2000.00603.x
   Roux AVD, 2006, ANN INTERN MED, V144, P822, DOI 10.7326/0003-4819-144-11-200606060-00008
   Rozanski A, 2005, J AM COLL CARDIOL, V45, P637, DOI 10.1016/j.jacc.2004.12.005
   Rozanski A, 1999, CIRCULATION, V99, P2192, DOI 10.1161/01.CIR.99.16.2192
   Rupp H, 2004, HERZ, V29, P673, DOI 10.1007/s00059-004-2602-4
   Shaw LJ, 2006, ATHEROSCLEROSIS, V188, P112, DOI 10.1016/j.atherosclerosis.2005.10.010
   Sniderman AD, 2007, CURR OPIN LIPIDOL, V18, P633, DOI 10.1097/MOL.0b013e3282f0dd33
   Stampfer MJ, 2000, NEW ENGL J MED, V343, P16, DOI 10.1056/NEJM200007063430103
   Stone NJ, 2005, AM J CARDIOL, V96, p53E, DOI 10.1016/j.amjcard.2005.06.006
   Tan MH, 2004, CLIN CHEM, V50, P1184, DOI 10.1373/clinchem.2004.031757
   Tankó LB, 2005, CIRCULATION, V111, P1883, DOI 10.1161/01.CIR.0000161801.65408.8D
   Taylor AJ, 2000, CIRCULATION, V101, P1243, DOI 10.1161/01.CIR.101.11.1243
   Taylor AJ, 2005, J AM COLL CARDIOL, V46, P807, DOI 10.1016/j.jacc.2005.05.049
   Taylor AJ, 2001, AM HEART J, V141, P463, DOI 10.1067/mhj.2001.113069
   Thurston RC, 2007, PSYCHOSOM MED, V69, P748, DOI 10.1097/PSY.0b013e31815772a3
   Tiemeier H, 2004, ARCH GEN PSYCHIAT, V61, P369, DOI 10.1001/archpsyc.61.4.369
   Vliegenthart R, 2005, CIRCULATION, V112, P572, DOI 10.1161/CIRCULATIONAHA.104.488916
   Von Schacky C, 2007, J CARDIOVASC MED, V8, pS46, DOI 10.2459/01.JCM.0000289273.87803.87
   Wang HX, 2007, J INTERN MED, V261, P245, DOI 10.1111/j.1365-2796.2006.01759.x
   Wang HX, 2006, PSYCHOTHER PSYCHOSOM, V75, P96, DOI 10.1159/000090893
   Weissler AM, 2004, JAMA-J AM MED ASSOC, V291, P299, DOI 10.1001/jama.291.3.299-c
   Willerson JT, 2004, CIRCULATION, V109, P2, DOI 10.1161/01.CIR.0000129535.04194.38
   Wong ND, 2004, AM J CARDIOL, V94, P431, DOI 10.1016/j.amjcard.2004.05.003
   Yoon HC, 2002, RADIOLOGY, V224, P236, DOI 10.1148/radiol.2241011191
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
NR 96
TC 9
Z9 9
U1 0
U2 4
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PY 2008
VL 71
IS 1
BP 45
EP 52
DI 10.1016/j.mehy.2008.02.008
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 316XK
UT WOS:000256982800008
PM 18406066
DA 2025-06-11
ER

PT J
AU Jansen, R
   Han, LKM
   Verhoeven, JE
   Aberg, KA
   van den Oord, ECGJ
   Milaneschi, Y
   Penninx, BWJH
AF Jansen, Rick
   Han, Laura K. M.
   Verhoeven, Josine E.
   Aberg, Karolina A.
   van den Oord, Edwin C. G. J.
   Milaneschi, Yuri
   Penninx, Brenda W. J. H.
TI An integrative study of five biological clocks in somatic and mental
   health
SO ELIFE
LA English
DT Article
ID DNA METHYLATION AGE; LEUKOCYTE TELOMERE LENGTH; ALL-CAUSE MORTALITY;
   PSYCHIATRIC-DISORDERS; ALCOHOL-CONSUMPTION; EPIGENETIC CLOCK;
   SEX-DIFFERENCES; METAANALYSIS; ANXIETY; ASSOCIATIONS
AB Biological clocks have been developed at different molecular levels and were found to be more advanced in the presence of somatic illness and mental disorders. However, it is unclear whether different biological clocks reflect similar aging processes and determinants. In similar to 3000 subjects, we examined whether five biological clocks (telomere length, epigenetic, transcriptomic, proteomic, and metabolomic clocks) were interrelated and associated to somatic and mental health determinants. Correlations between biological aging indicators were small (all r < 0.2), indicating little overlap. The most consistent associations of advanced biological aging were found for male sex, higher body mass index (BMI), metabolic syndrome, smoking, and depression. As compared to the individual clocks, a composite index of all five clocks showed most pronounced associations with health determinants. The large effect sizes of the composite index and the low correlation between biological aging indicators suggest that one's biological age is best reflected by combining aging measures from multiple cellular levels.
C1 [Jansen, Rick; Han, Laura K. M.; Verhoeven, Josine E.; Milaneschi, Yuri; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst & Amsterdam Neurosci, Dept Psychiat, Amsterdam UMC, Amsterdam, Netherlands.
   [Aberg, Karolina A.; van den Oord, Edwin C. G. J.] Virginia Commonwealth Univ, Ctr Biomarker Res & Precis Med, Richmond, VA USA.
C3 University of Amsterdam; Vrije Universiteit Amsterdam; Virginia
   Commonwealth University
RP Jansen, R (corresponding author), Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst & Amsterdam Neurosci, Dept Psychiat, Amsterdam UMC, Amsterdam, Netherlands.
EM ri.jansen@ggzingeest.nl
RI Jansen, Ritsert/C-1160-2013; Penninx, Brenda/S-7627-2017; Han,
   Laura/AGV-3472-2022; Aberg, Karolina/A-6772-2010
OI Jansen, Rick/0000-0002-3333-6737; Han, Laura/0000-0001-9647-3723;
   Milaneschi, Yuri/0000-0002-3697-6617
FU Netherlands Organisation for Health Research and Development (ZonMw)
   [10-000-1002]; VU University Medical Center; GGZ inGeest; Leiden
   University Medical Center; Leiden University; GGZ Rivierduinen;
   University Medical Center Groningen; University of Groningen; Lentis;
   GGZ Friesland; GGZ Drenthe; Rob Giel Onderzoekscentrum; NWO-VICI
   [91811602]; NIMH [R01MH099110]; BBMRI-NL; Dutch government (NWO)
   [184.021.007, 184033111]; US National Institute of Mental Health
   [RC2MH089951]
FX The infrastructure for the NESDA study (http://www.nesda.nl) is funded
   through the Geestkracht program of the Netherlands Organisation for
   Health Research and Development (ZonMw, grant number 10-000-1002) and
   financial contributions by participating universities and mental health
   care organizations (VU University Medical Center, GGZ inGeest, Leiden
   University Medical Center, Leiden University, GGZ Rivierduinen,
   University Medical Center Groningen, University of Groningen, Lentis,
   GGZ Friesland, GGZ Drenthe, Rob Giel Onderzoekscentrum). Telomere length
   assaying was supported through a NWO-VICI grant (number 91811602).
   Methylation sequencing was supported by NIMH grant R01MH099110.
   Metabolomics data were generated within the framework of the BBMRI
   Metabolomics Consortium funded by BBMRI-NL, a research infrastructure
   financed by the Dutch government (NWO, grant nr 184.021.007 and
   184033111). Gene expression data were funded by the US National
   Institute of Mental Health (RC2MH089951).
CR Aberg KA, 2020, MOL PSYCHIATR, V25, P1344, DOI 10.1038/s41380-018-0247-6
   Austad SN, 2016, CELL METAB, V23, P1022, DOI 10.1016/j.cmet.2016.05.019
   BABOR TF, 1989, ADDICT BEHAV, V14, P139, DOI 10.1016/0306-4603(89)90043-9
   Belsky DW, 2020, ELIFE, V9, DOI 10.7554/eLife.54870
   Belsky DW, 2018, AM J EPIDEMIOL, V187, P1220, DOI 10.1093/aje/kwx346
   Belsky DW, 2015, P NATL ACAD SCI USA, V112, pE7164, DOI 10.1073/pnas.1518878112
   Boks MP, 2015, PSYCHONEUROENDOCRINO, V51, P506, DOI 10.1016/j.psyneuen.2014.07.011
   Bot M, 2020, BIOL PSYCHIAT, V87, P409, DOI 10.1016/j.biopsych.2019.08.016
   Breitling LP, 2016, CLIN EPIGENETICS, V8, DOI 10.1186/s13148-016-0186-5
   Cawthon RM, 2002, NUCLEIC ACIDS RES, V30, DOI 10.1093/nar/30.10.e47
   Chen BH, 2017, AGING-US, V9, P1983, DOI 10.18632/aging.101293
   Chen BH, 2016, AGING-US, V8, P1844, DOI 10.18632/aging.101020
   Christiansen L, 2016, AGING CELL, V15, P149, DOI 10.1111/acel.12421
   Clark SL, 2020, MOL PSYCHIATR, V25, P1334, DOI 10.1038/s41380-019-0516-z
   Cole JH, 2019, MOL PSYCHIATR, V24, P266, DOI 10.1038/s41380-018-0098-1
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   Darrow SM, 2016, PSYCHOSOM MED, V78, P776, DOI 10.1097/PSY.0000000000000356
   de Graaf R, 2002, AM J PSYCHIAT, V159, P620, DOI 10.1176/appi.ajp.159.4.620
   Diniz BS, 2018, AM J GERIAT PSYCHIAT, V26, P964, DOI 10.1016/j.jagp.2018.06.013
   Fehrmann RSN, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002197
   Fischer K, 2014, PLOS MED, V11, DOI 10.1371/journal.pmed.1001606
   Franceschi C, 2018, NAT REV ENDOCRINOL, V14, P576, DOI 10.1038/s41574-018-0059-4
   Frasca D, 2017, FRONT IMMUNOL, V8, DOI [10.3389/fimmu.2017.01003, 10.3389/fimmu.2017.01745]
   Gaspersz R, 2018, PSYCHOTHER PSYCHOSOM, V87, P308, DOI 10.1159/000491933
   Gerrits MM, 2013, PSYCHOTHER PSYCHOSOM, V82, P64, DOI 10.1159/000338636
   Gielen M, 2018, AM J CLIN NUTR, V108, P453, DOI 10.1093/ajcn/nqy107
   Guralnik JM, 1996, ANNU REV PUBL HEALTH, V17, P25, DOI 10.1146/annurev.pu.17.050196.000325
   Han LKM, 2019, PSYCHONEUROENDOCRINO, V106, P293, DOI 10.1016/j.psyneuen.2019.04.004
   Han LKM, 2018, AM J PSYCHIAT, V175, P774, DOI 10.1176/appi.ajp.2018.17060595
   Hannum G, 2013, MOL CELL, V49, P359, DOI 10.1016/j.molcel.2012.10.016
   Hastings WJ, 2019, PSYCHONEUROENDOCRINO, V106, P171, DOI 10.1016/j.psyneuen.2019.03.012
   Hillary RF, 2021, MOL PSYCHIATR, V26, P3806, DOI 10.1038/s41380-019-0616-9
   Horvath S, 2018, NAT REV GENET, V19, P371, DOI 10.1038/s41576-018-0004-3
   Horvath S, 2013, GENOME BIOL, V14, DOI 10.1186/gb-2013-14-10-r115
   Horvath S, 2012, GENOME BIOL, V13, DOI 10.1186/gb-2012-13-10-r97
   Jansen R, 2017, HUM MOL GENET, V26, P1444, DOI 10.1093/hmg/ddx043
   Jansen R, 2014, BMC GENOMICS, V15, DOI 10.1186/1471-2164-15-33
   Jin X, 2018, MEDICINE, V97, DOI [10.1097/MD.0000000000012489, 10.1097/md.0000000000012489]
   Jylhävä J, 2017, EBIOMEDICINE, V21, P29, DOI 10.1016/j.ebiom.2017.03.046
   Lamers F, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.115
   Langmead B, 2012, NAT METHODS, V9, P357, DOI [10.1038/NMETH.1923, 10.1038/nmeth.1923]
   Levine ME, 2018, AGING-US, V10, P573, DOI 10.18632/aging.101414
   Li X, 2020, ELIFE, V9, DOI [10.7554/eLife.51507, 10.7554/eLife.53734]
   Li ZC, 2017, J PSYCHIATR RES, V93, P64, DOI 10.1016/j.jpsychires.2017.06.002
   Lindqvist D, 2015, NEUROSCI BIOBEHAV R, V55, P333, DOI 10.1016/j.neubiorev.2015.05.007
   López-Otín C, 2013, CELL, V153, P1194, DOI 10.1016/j.cell.2013.05.039
   Marioni RE, 2016, INT J EPIDEMIOL, V45, P424, DOI 10.1093/ije/dyw041
   Marioni RE, 2015, GENOME BIOL, V16, DOI 10.1186/s13059-015-0584-6
   Milaneschi Y, 2014, CURR PHARM DESIGN, V20, P3114, DOI 10.2174/13816128113196660060
   Mons U, 2017, AM J EPIDEMIOL, V185, P1317, DOI 10.1093/aje/kww210
   Murabito JM, 2018, J GERONTOL A-BIOL, V73, P757, DOI 10.1093/gerona/glx144
   Nelson PG, 2020, J GERONTOL A-BIOL, V75, P466, DOI 10.1093/gerona/glz174
   Penninx BWJH, 2008, INT J METH PSYCH RES, V17, P121, DOI 10.1002/mpr.256
   Perna L, 2016, CLIN EPIGENETICS, V8, DOI 10.1186/s13148-016-0228-z
   Peters MJ, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms9570
   Révész D, 2018, J CLIN ENDOCR METAB, V103, P148, DOI 10.1210/jc.2017-01625
   Révész D, 2015, J CLIN ENDOCR METAB, V100, P3050, DOI 10.1210/JC.2015-1995
   Révész D, 2014, J CLIN ENDOCR METAB, V99, P4607, DOI 10.1210/jc.2014-1851
   Rush AJ, 1996, PSYCHOL MED, V26, P477, DOI 10.1017/S0033291700035558
   Shabalin AA, 2018, BIOINFORMATICS, V34, P2283, DOI 10.1093/bioinformatics/bty069
   Soininen P, 2015, CIRC-CARDIOVASC GENE, V8, P192, DOI 10.1161/CIRCGENETICS.114.000216
   van den Akker E.B., 2019, PREDICTING BIOL AGE, DOI [10.1101/632919, DOI 10.1101/632919]
   Verhoeven JE, 2014, MOL PSYCHIATR, V19, P895, DOI 10.1038/mp.2013.151
   Verhoeven Josine E, 2018, Mol Neuropsychiatry, V4, P90, DOI 10.1159/000491431
   Wang Q, 2018, AGEING RES REV, V48, P11, DOI 10.1016/j.arr.2018.09.002
   Whalley H.C., 2017, BioRxiv, P210666, DOI DOI 10.1101/210666
   Wohleb ES, 2016, NAT REV NEUROSCI, V17, P497, DOI 10.1038/nrn.2016.69
   Wolf EJ, 2018, PSYCHONEUROENDOCRINO, V92, P123, DOI 10.1016/j.psyneuen.2017.12.007
   Wright FA, 2014, NAT GENET, V46, P430, DOI 10.1038/ng.2951
   Würtz P, 2016, INT J EPIDEMIOL, V45, P1493, DOI 10.1093/ije/dyw175
   Würtz P, 2015, CIRCULATION, V131, P774, DOI 10.1161/CIRCULATIONAHA.114.013116
   Würtz P, 2012, DIABETES, V61, P1372, DOI 10.2337/db11-1355
   Xia Xian, 2017, F1000Res, V6, P860, DOI 10.12688/f1000research.10692.1
NR 73
TC 59
Z9 63
U1 4
U2 20
PU eLIFE SCIENCES PUBL LTD
PI CAMBRIDGE
PA SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND
SN 2050-084X
J9 ELIFE
JI eLife
PD FEB 9
PY 2021
VL 10
AR e59479
DI 10.7554/eLife.59479
PG 20
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Life Sciences & Biomedicine - Other Topics
GA QI2YZ
UT WOS:000618847100001
PM 33558008
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Buchmann, AF
   Kopf, D
   Westphal, S
   Lederbogen, F
   Banaschewski, T
   Esser, G
   Schmidt, MH
   Zimmermann, US
   Laucht, M
   Deuschle, M
AF Buchmann, Arlette F.
   Kopf, Daniel
   Westphal, Sabine
   Lederbogen, Florian
   Banaschewski, Tobias
   Esser, Guenter
   Schmidt, Martin H.
   Zimmermann, Ulrich S.
   Laucht, Manfred
   Deuschle, Michael
TI Impact of Early Parental Child-Rearing Behavior on Young Adults'
   Cardiometabolic Risk Profile: A Prospective Study
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE child-rearing behavior; metabolic risk factors; longitudinal study
ID LIPOPROTEIN CHOLESTEROL LEVELS; INSULIN-RESISTANCE SYNDROME; BLOOD LIPID
   CONCENTRATIONS; CORONARY HEART-DISEASE; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; MATERNAL-CARE; STRESS; ADOLESCENTS; HERITABILITY
AB Objective: To examine prospectively whether early parental child-rearing behavior is a predictor of cardiometabolic outcome in young adulthood when other potential risk factors are controlled. Metabolic factors associated with increased risk for cardiovascular disease have been found to vary, depending on lifestyle as well as genetic predisposition. Moreover, there is evidence suggesting that environmental conditions, such as stress in pre- and postnatal life, may have a sustained impact on an individual's metabolic risk profile. Methods: Participants were drawn from a prospective, epidemiological, cohort study followed up from birth into young adulthood. Parent interviews and behavioral observations at the age of 3 months were conducted to assess child-rearing practices and mother-infant interaction in the home setting and in the laboratory. In 279 participants, anthropometric characteristics, low-density lipoprotein and high-density lipoprotein cholesterol, apolipoproteins, and triglycerides were recorded at age 19 years. In addition, structured interviews were administered to the young adults to assess indicators of current lifestyle and education. Results: Adverse early-life interaction experiences were significantly associated with lower levels of high-density lipoprotein cholesterol and apolipoprotein A1 in young adulthood. Current lifestyle variables and level of education did not account for this effect, although habitual smoking and alcohol consumption also contributed significantly to cardiometabolic outcomes. Conclusions: These findings suggest that early parental child-rearing behavior may predict health outcome in later life through its impact on metabolic parameters in adulthood.
C1 [Kopf, Daniel; Lederbogen, Florian; Deuschle, Michael] Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, D-68159 Mannheim, Germany.
   [Buchmann, Arlette F.; Banaschewski, Tobias; Schmidt, Martin H.; Laucht, Manfred] Cent Inst Mental Hlth, Dept Child & Adolescent Psychiat & Psychotherapy, D-68159 Mannheim, Germany.
   [Westphal, Sabine] Magdeburg Univ Hosp, Inst Clin Chem & Pathobiochem, Magdeburg, Germany.
   [Esser, Guenter; Laucht, Manfred] Univ Potsdam, Div Clin Psychol, Dept Psychol, Potsdam, Germany.
   [Zimmermann, Ulrich S.] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Psychiat & Psychotherapy, Dresden, Germany.
C3 Central Institute of Mental Health; Central Institute of Mental Health;
   University Hospital Magdeburg; University of Potsdam; Technische
   Universitat Dresden; Carl Gustav Carus University Hospital
RP Deuschle, M (corresponding author), Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, J 5, D-68159 Mannheim, Germany.
EM michael.deuschle@zi-mannheim.de
RI Kopf, Daniel/G-3563-2010; Zimmermann, Ulrich/B-9357-2011; Deuschle,
   Michael/E-4638-2012; Banaschewski, Tobias/ABE-5985-2020
OI Banaschewski, Tobias/0000-0003-4595-1144
FU German Research Foundation (DFG); Federal Ministry for Education and
   Research; "National Genome Research Network"
FX This study was supported by grants from the German Research Foundation
   (DFG) and the Federal Ministry for Education and Research as part of the
   "Baden-Wuerttemberg Consortium for Addiction Research" and the "National
   Genome Research Network" (A. F. B., G. E., M. H. S., U.S.Z., M. L.).
CR Abbott RD, 1997, ANN EPIDEMIOL, V7, P417, DOI 10.1016/S1047-2797(97)00043-4
   Ambrosch A, 1998, DIABETES CARE, V21, P2077, DOI 10.2337/diacare.21.12.2077
   [Anonymous], 2003, ASSESSING ALCOHOL PR
   [Anonymous], 1984, ADM MANUAL HOME OBSE
   AUSTIN MA, 1987, AM J EPIDEMIOL, V125, P308, DOI 10.1093/oxfordjournals.aje.a114531
   BARKER DJP, 1993, LANCET, V341, P938, DOI 10.1016/0140-6736(93)91224-A
   Bays HE, 2009, AM J MED, V122, pS26, DOI 10.1016/j.amjmed.2008.10.015
   Benn M, 2007, ARTERIOSCL THROM VAS, V27, P661, DOI 10.1161/01.ATV.0000255580.73689.8e
   BERGSTROM E, 1995, ATHEROSCLEROSIS, V117, P1, DOI 10.1016/0021-9150(95)05549-C
   BUCHMANN AF, 2008, J PSYCHOPHARMAC 1121
   Burdge GC, 2007, BRIT J NUTR, V97, P1036, DOI 10.1017/S0007114507682920
   Caldji C, 1998, P NATL ACAD SCI USA, V95, P5335, DOI 10.1073/pnas.95.9.5335
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Fóscolo DRC, 2008, METAB BRAIN DIS, V23, P375, DOI 10.1007/s11011-008-9102-9
   Costanza MC, 2005, AM J EPIDEMIOL, V161, P714, DOI 10.1093/aje/kwi103
   Després JP, 2000, ATHEROSCLEROSIS, V153, P263, DOI 10.1016/S0021-9150(00)00603-1
   Diniz JMM, 2004, BRIT J NUTR, V92, P905, DOI 10.1079/BJN20041288
   Dong MX, 2004, CIRCULATION, V110, P1761, DOI 10.1161/01.CIR.0000143074.54995.7F
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Edwards KL, 1997, GENET EPIDEMIOL, V14, P241, DOI 10.1002/(SICI)1098-2272(1997)14:3<241::AID-GEPI3>3.0.CO;2-8
   ESSER G, 1989, Z KINDER JUG-PSYCH, V17, P185
   FALL CHD, 1992, BRIT MED J, V304, P801, DOI 10.1136/bmj.304.6830.801
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Freeman MS, 2002, DIABETIC MED, V19, P994, DOI 10.1046/j.1464-5491.2002.00843.x
   Haley DW, 2003, CHILD DEV, V74, P1534, DOI 10.1111/1467-8624.00621
   Hausenloy DJ, 2008, HEART, V94, P706, DOI 10.1136/hrt.2007.125401
   Heim C, 2001, BIOL PSYCHIAT, V49, P1023, DOI 10.1016/S0006-3223(01)01157-X
   HELLER DA, 1993, NEW ENGL J MED, V328, P1150, DOI 10.1056/NEJM199304223281603
   Kapoor A, 2008, BRAIN RES REV, V57, P586, DOI 10.1016/j.brainresrev.2007.06.013
   Kaufman D, 2007, DIABETES, V56, P1382, DOI 10.2337/db06-1409
   Kraja Aldi T., 2008, Endocrine Metabolic & Immune Disorders-Drug Targets, V8, P198, DOI 10.2174/187153008785700145
   Laucht M, 2000, J AM ACAD CHILD PSY, V39, P1229, DOI 10.1097/00004583-200010000-00009
   Laucht M, 2001, DEV MED CHILD NEUROL, V43, P292, DOI 10.1017/S0012162201000561
   Laucht M, 1997, J CHILD PSYCHOL PSYC, V38, P843, DOI 10.1111/j.1469-7610.1997.tb01602.x
   Liu D, 1997, SCIENCE, V277, P1659, DOI 10.1126/science.277.5332.1659
   Loizzo A, 2006, PEDIATR RES, V59, P111, DOI 10.1203/01.pdr.0000190575.12965.ce
   Martin G, 2004, J NERV MENT DIS, V192, P650, DOI 10.1097/01.nmd.0000142028.10056.c6
   Meaney MJ, 2007, TRENDS MOL MED, V13, P269, DOI 10.1016/j.molmed.2007.05.003
   MULLER R, 1991, CHANGING TRENDS CONS
   OAKLEYBROWNE MA, 1995, J AFFECT DISORDERS, V34, P13, DOI 10.1016/0165-0327(94)00099-U
   Ouellet-Morin I, 2009, BIOL PSYCHIAT, V65, P409, DOI 10.1016/j.biopsych.2008.10.003
   Owen CG, 2002, PEDIATRICS, V110, P597, DOI 10.1542/peds.110.3.597
   Owen CG, 2006, AM J CLIN NUTR, V84, P1043, DOI 10.1093/ajcn/84.5.1043
   Pearce MS, 2006, DIABETES-METAB RES, V22, P118, DOI 10.1002/dmrr.573
   Pettitt DJ, 1997, LANCET, V350, P166, DOI 10.1016/S0140-6736(96)12103-6
   Phillips DIW, 2007, J INTERN MED, V261, P453, DOI 10.1111/j.1365-2796.2007.01801.x
   Phillips DIW, 2006, ANN NY ACAD SCI, V1083, P28, DOI 10.1196/annals.1367.027
   Pi-Sunyer FX, 1998, OBES RES, V6, p51S
   Ravelli ACJ, 2000, ARCH DIS CHILD, V82, P248, DOI 10.1136/adc.82.3.248
   Sato T, 1998, PSYCHOL MED, V28, P737, DOI 10.1017/S0033291797006430
   Simmons Rebecca A, 2007, Curr Opin Endocrinol Diabetes Obes, V14, P13, DOI 10.1097/MED.0b013e328013da5b
   Singhal A, 2004, LANCET, V363, P1571, DOI 10.1016/S0140-6736(04)16198-9
   SOBELL LC, 1988, BRIT J ADDICT, V83, P393
   Victora CG, 2006, J EPIDEMIOL COMMUN H, V60, P621, DOI 10.1136/jech.2005.044156
   von Kries R, 1999, BRIT MED J, V319, P147, DOI 10.1136/bmj.319.7203.147
NR 55
TC 25
Z9 28
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD FEB-MAR
PY 2010
VL 72
IS 2
BP 156
EP 162
DI 10.1097/PSY.0b013e3181c88343
PG 7
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 559CK
UT WOS:000274797700008
PM 19995883
DA 2025-06-11
ER

PT J
AU Ringen, PA
   Lund-Stenvold, E
   Andreassen, OA
   Gaarden, TL
   Hartberg, CB
   Johnsen, E
   Myklatun, S
   Osnes, K
   Sorensen, K
   Sorensen, K
   Vaaler, A
   Tonstad, S
   Engh, JA
   Hoye, A
AF Ringen, Petter A.
   Lund-Stenvold, Elisabeth
   Andreassen, Ole A.
   Gaarden, Torfinn L.
   Hartberg, Cecilie B.
   Johnsen, Erik
   Myklatun, Silje
   Osnes, Kare
   Sorensen, Kirsten
   Sorensen, Kjetil
   Vaaler, Arne
   Tonstad, Serena
   Engh, John A.
   Hoye, Anne
TI Quality of clinical management of cardiometabolic risk factors in
   patients with severe mental illness in a specialist mental health care
   setting
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Severe mental illness; schizophrenia; cardiovascular risk;
   cardiometabolic health; cardiometabolic risk; mortality risk reduction;
   health resource
ID SEDENTARY BEHAVIOR; BIPOLAR DISORDER; SUBSTANCE-ABUSE; SCHIZOPHRENIA;
   MORTALITY; ANTIPSYCHOTICS; METAANALYSIS; OBESITY; SCALE
AB Purpose Cardiometabolic disease in patients with severe mental illness is a major cause of shortened life expectancy. There is sparse evidence of real-world clinical risk prevention practice. We investigated levels of assessments of cardiometabolic risk factors and risk management interventions in patients with severe mental illness in the Norwegian mental health service according to an acknowledged international standard. Methods We collected data from 264 patients residing in six country-wide health trusts for: (a) assessments of cardiometabolic risk and (b) assessments of levels of risk reducing interventions. Logistic regressions were employed to investigate associations between risk and interventions. Results Complete assessments of all cardiometabolic risk variables were performed in 50% of the participants and 88% thereof had risk levels requiring intervention according to the standard. Smoking cessation advice was provided to 45% of daily smokers and 4% were referred to an intervention program. Obesity was identified in 62% and was associated with lifestyle interventions. Reassessment of psychotropic medication was done in 28% of the obese patients. Women with obesity were less likely to receive dietary advice, and use of clozapine or olanzapine reduced the chances for patients with obesity of getting weight reducing interventions. Conclusions Nearly nine out of the ten participants were identified as being at cardiometabolic high risk and only half of the participants were adequately screened. Women with obesity and patients using antipsychotics with higher levels of cardiometabolic side effects had fewer adequate interventions. The findings underscore the need for standardized recommendations for identification and provision of cardiometabolic risk reducing interventions in all patients with severe mental illness.
C1 [Ringen, Petter A.; Hartberg, Cecilie B.; Sorensen, Kirsten] Univ Oslo, Div Mental Hlth & Addict, Oslo Univ Hosp, Oslo, Norway.
   [Ringen, Petter A.; Andreassen, Ole A.; Hartberg, Cecilie B.; Sorensen, Kirsten] Univ Oslo, Inst Clin Med, Oslo, Norway.
   [Lund-Stenvold, Elisabeth; Hoye, Anne] UiT Arctic Univ Norway, Dept Clin Med, Tromso, Norway.
   [Lund-Stenvold, Elisabeth; Hoye, Anne] Univ Hosp North Norway, Dept Mental Hlth & Subst Abuse, Tromso, Norway.
   [Andreassen, Ole A.] Univ Oslo, NORMENT Ctr Excellence, Div Mental Hlth & Addict, Oslo Univ Hosp, Oslo, Norway.
   [Gaarden, Torfinn L.; Myklatun, Silje; Osnes, Kare] Diakonhjemmet Hosp, Div Mental Hlth & Subst Abuse, Oslo, Norway.
   [Johnsen, Erik] Univ Bergen, NORMENT Ctr Excellence, Div Psychiat, Haukeland Univ Hosp, Bergen, Norway.
   [Johnsen, Erik] Univ Bergen, Dept Clin Med, Bergen, Norway.
   [Sorensen, Kjetil] St Olavs Univ Hosp, Div Mental Hlth, Trondheim, Norway.
   [Vaaler, Arne] NTNU, Dept Acute Psychiat, St Olavs Univ Hosp, Trondheim, Norway.
   [Vaaler, Arne] NTNU, Dept Mental Hlth, Trondheim, Norway.
   [Tonstad, Serena] Oslo Univ Hosp, Sect Prevent Cardiol Endocrinol Morbid Obes & Pre, Oslo, Norway.
   [Engh, John A.] Vestfold Hosp Trust, Div Mental Hlth & Addict, Tonsberg, Norway.
C3 University of Oslo; University of Oslo; UiT The Arctic University of
   Tromso; UiT The Arctic University of Tromso; University Hospital of
   North Norway; University of Oslo; Diakonhjemmet Hospital; University of
   Bergen; Haukeland University Hospital; University of Bergen; Norwegian
   University of Science & Technology (NTNU); Norwegian University of
   Science & Technology (NTNU); Norwegian University of Science &
   Technology (NTNU); University of Oslo
RP Ringen, PA (corresponding author), Univ Oslo, Div Mental Hlth & Addict, Oslo Univ Hosp, Oslo, Norway.; Ringen, PA (corresponding author), Univ Oslo, Inst Clin Med, Oslo, Norway.
EM p.a.ringen@medisin.uio.no
RI Engh, John/AAG-6446-2021; Andreassen, Ole/AAY-7531-2020; ringen,
   petter/C-5036-2011
OI Andreassen, Ole A./0000-0002-4461-3568
FU RCN [223273, 300309]; South-East Norway Health Authority [2019-108,
   2017-112]
FX The research was supported by RCN [grant #223273, 300309] and South-East
   Norway Health Authority [grants #2019-108 and #2017-112].
CR Allison DB, 2009, AM J PREV MED, V36, P341, DOI 10.1016/j.amepre.2008.11.020
   Andersen E, 2018, SCHIZOPHR RES, V201, P98, DOI 10.1016/j.schres.2018.05.038
   [Anonymous], 2018, Guidelines on the management of acute respiratory distress syndrome
   [Anonymous], SOMATIC HLTH LIVING
   [Anonymous], 2015, NASJONAL FAGLIG RETN
   [Anonymous], 2016, EV IMPL LEST 2014
   Barbui C, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009780.pub2
   Birkenaes AB, 2007, J CLIN PSYCHIAT, V68, P917, DOI 10.4088/JCP.v68n0614
   Chooi YC, 2019, METABOLISM, V92, P6, DOI 10.1016/j.metabol.2018.09.005
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   Crowley RA, 2015, ANN INTERN MED, V163, P298, DOI 10.7326/M15-0510
   Crump C, 2013, JAMA PSYCHIAT, V70, P931, DOI 10.1001/jamapsychiatry.2013.1394
   Curtis J, 2012, EARLY INTERV PSYCHIA, V6, P347, DOI 10.1111/j.1751-7893.2011.00315.x
   De Hert M, 2009, EUR PSYCHIAT, V24, P412, DOI 10.1016/j.eurpsy.2009.01.005
   Firth J, 2018, WORLD PSYCHIATRY, V17, P365, DOI 10.1002/wps.20571
   Henderson DC, 2015, LANCET PSYCHIAT, V2, P452, DOI 10.1016/S2215-0366(15)00115-7
   HETI Positive Cardiometabolic Health algorithm, 2015, IPHYS
   Hoilund H, 2020, NORD J PSYCHIAT, V74, P208, DOI 10.1080/08039488.2019.1690044
   Janney CA, 2013, SCHIZOPHR RES, V145, P63, DOI 10.1016/j.schres.2013.01.010
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kurtze N, 2007, EUR J EPIDEMIOL, V22, P379, DOI 10.1007/s10654-007-9110-9
   Marder SR, 2004, AM J PSYCHIAT, V161, P1334, DOI 10.1176/appi.ajp.161.8.1334
   McGinty EE, 2016, SCHIZOPHRENIA BULL, V42, P96, DOI 10.1093/schbul/sbv101
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Newcomer JW, 2005, CNS DRUGS, V19, P1
   Pedersen G, 2007, COMPR PSYCHIAT, V48, P88, DOI 10.1016/j.comppsych.2006.03.008
   Plana-Ripoll O, 2019, LANCET, V394, P1827, DOI 10.1016/S0140-6736(19)32316-5
   Ringen PA, 2018, NORD J PSYCHIAT, V72, P296, DOI 10.1080/08039488.2018.1449012
   Rodevand L, 2019, ACTA PSYCHIAT SCAND, V139, P348, DOI 10.1111/acps.13008
   Rössler W, 2005, EUR NEUROPSYCHOPHARM, V15, P399, DOI 10.1016/j.euroneuro.2005.04.009
   Saha S, 2007, ARCH GEN PSYCHIAT, V64, P1123, DOI 10.1001/archpsyc.64.10.1123
   Sarris J, 2015, LANCET PSYCHIAT, V2, P271, DOI 10.1016/S2215-0366(14)00051-0
   Schroeder SA, 2010, ANNU REV PUBL HEALTH, V31, P297, DOI 10.1146/annurev.publhealth.012809.103701
   Solmi M, 2017, THER CLIN RISK MANAG, V13, P757, DOI 10.2147/TCRM.S117321
   Spahlholz J, 2016, OBES REV, V17, P43, DOI 10.1111/obr.12343
   Tenback D, 2012, J CLIN PSYCHOPHARM, V32, P31, DOI 10.1097/JCP.0b013e31823f3c43
   Torniainen M, 2015, SCHIZOPHRENIA BULL, V41, P656, DOI 10.1093/schbul/sbu164
   Vancampfort D, 2012, PSYCHIAT RES, V200, P73, DOI 10.1016/j.psychres.2012.03.046
   Vermeulen J, 2017, PSYCHOL MED, V47, P2217, DOI 10.1017/S0033291717000873
NR 39
TC 7
Z9 7
U1 1
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0803-9488
EI 1502-4725
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PD NOV 1
PY 2022
VL 76
IS 8
BP 602
EP 609
DI 10.1080/08039488.2022.2039288
EA FEB 2022
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 5X8GP
UT WOS:000761359700001
PM 35200088
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU van de Vyver, M
   Benecke, RM
   van den Heuvel, L
   Kruger, MJ
   Powrie, Y
   Seedat, S
   Smith, C
AF van de Vyver, M.
   Benecke, R. M.
   van den Heuvel, L.
   Kruger, M. J.
   Powrie, Y.
   Seedat, S.
   Smith, C.
TI Posttraumatic stress disorder is characterized by functional
   dysregulation of dermal fibroblasts
SO BIOCHIMIE
LA English
DT Article
DE Calcium flux; Cellular dysfunction; Inflammation; Stress; Anxiety
ID METABOLIC SYNDROME; EXPRESSION; SYMPTOMS; INFLAMMATION; PREVALENCE;
   RISK; PTSD; IL-7
AB Incidence of mental health disorders are rising in modernity, with psychological stress linked to a propensity for developing various chronic diseases due to a relative inability of the body to counter the allostatic load on cellular level. Despite these high rates of comorbidities associated with posttraumatic stress disorder (PTSD), there is still a lack of understanding in terms of the peripheral effects of PTSD on tissue level. Therefore, the purpose of this study was to profile basal dermal fibroblast functional status in PTSD using a wide range of markers involved in the cell-to-cell communication facilitated by fibroblasts. Primary dermal fibroblasts derived from patients diagnosed with PTSD (n = 11) and matched trauma exposed controls (i.e. who did not develop PTSD, n = 10) were cultured using standard techniques. The patients and controls were matched based on age, sex, body-mass index (BMI) and lifestyle. The growth rate, population doubling time, cell surface marker expression (CD31, FNDC5) (flow cytometry), secretome (TIMP-2, MMP-9) (ELISAs), intracellular signalling capacity (Fluo-4 Ca2 2 flux) and gene expression (IL-6, IL-10, PTX-3, iNOS, Arg1) were compared between groups. The data illustrated significant PTSDassociated fibroblast conditioning resulting in a blunted signalling capacity. This observation highlights the importance of including tissue-specific investigations in future studies focused on elucidating the association between PTSD and subsequent risk for somatic disease. (c) 2024 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [van de Vyver, M.; Kruger, M. J.; Powrie, Y.; Smith, C.] Stellenbosch Univ, Fac Med & Hlth Sci, Dept Med, Expt Med Res Grp,Div Internal Med, Francie van Zijl Dr, ZA-7505 Parow, South Africa.
   [Benecke, R. M.] Stellenbosch Univ, Fac Med & Hlth Sci, Dept Med, Div Clin Pharmacol, Stellenbosch, South Africa.
   [van den Heuvel, L.; Seedat, S.] Univ Stellenbosch, Fac Med & Hlth Sci, Dept Psychiat, Francie van Zijl Dr, ZA-7505 Cape Town, South Africa.
   [van den Heuvel, L.; Seedat, S.] Stellenbosch Univ, Genom Brain Disorders Res Unit, Fac Med & Hlth Sci, South African Med Res Council,Dept Psychiat, Cape Town, South Africa.
C3 Stellenbosch University; Stellenbosch University; Stellenbosch
   University; South African Medical Research Council
RP Smith, C (corresponding author), Stellenbosch Univ, Fac Med & Hlth Sci, Dept Med, Expt Med Res Grp,Div Internal Med, Francie van Zijl Dr, ZA-7505 Parow, South Africa.
EM csmith@sun.ac.za
RI M, van/H-3433-2019; van den Heuvel, Lotte/GLR-5530-2022; Powrie,
   Yigael/CAG-1220-2022; Powrie, Yigael/R-1094-2018; Smith,
   Carine/D-7159-2012
OI van de Vyver, Mari/0000-0002-0861-2939; Powrie,
   Yigael/0000-0001-8044-9390; Benecke, Rohan/0000-0002-8854-0380; Smith,
   Carine/0000-0001-5924-9204
FU South African Medical Research Council from the South African National
   Treasury [MRC-RFA-IFSP-01-2013]; National Research Foundation of South
   Africa [138430]; South African Medical Research Council
FX Research reported in this publication was supported by the South African
   Medical Research Council for the "Shared Roots" Flagship Project, Grant
   no. MRC-RFA-IFSP-01-2013/SHARED ROOTS" through funding received from the
   South African National Treasury under its Economic Competitiveness and
   Support Package. Its contents are solely the responsibility of the
   authors and do not necessarily represent the official views of the South
   African Medical Research Council. The work by Leigh van den Heuvel was
   supported in part by the National Research Foundation of South Africa
   (Grant Number 138430) and by the South African Medical Research Council
   under a Self-Initiated Research Grant. The content hereof is the sole
   responsibility of the authors and do not necessarily represent the
   official views of the SAMRC or the funders. Professors Robert Fenn and
   Jean Millar are acknowledged for salary funding. Funders have played no
   role in the study design, data collection, analysis, and interpretation
   and in writing the manuscript.
CR ALBINA JE, 1990, J IMMUNOL, V144, P3877
   Auburger G, 2012, MOL NEUROBIOL, V46, P20, DOI 10.1007/s12035-012-8245-1
   Bachis A, 2008, NEUROPHARMACOLOGY, V55, P1114, DOI 10.1016/j.neuropharm.2008.07.014
   Bayley CC, 2021, MOL PSYCHIATR, V26, P2286, DOI 10.1038/s41380-020-0730-8
   Busschots S, 2015, METHODSX, V2, P8, DOI 10.1016/j.mex.2014.11.002
   Cao RY, 2019, BIOCHIMIE, V158, P111, DOI 10.1016/j.biochi.2019.01.001
   Doni A, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.676702
   Edmondson D, 2013, AM HEART J, V166, P806, DOI 10.1016/j.ahj.2013.07.031
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   Ferrini MG, 2002, NITRIC OXIDE-BIOL CH, V6, P283, DOI 10.1006/niox.2001.0421
   Fournier M, 2014, SCHIZOPHRENIA BULL, V40, P973, DOI 10.1093/schbul/sbu053
   Gao F, 2023, NEUROPHARMACOLOGY, V222, DOI 10.1016/j.neuropharm.2022.109306
   Gaspar L, 2014, EUR J NEUROSCI, V40, P2206, DOI 10.1111/ejn.12602
   Hori H, 2019, PSYCHIAT CLIN NEUROS, V73, P143, DOI 10.1111/pcn.12820
   Hsieh PF, 2012, MOL IMMUNOL, V50, P74, DOI 10.1016/j.molimm.2011.12.004
   Huang HM, 2005, NEUROBIOL AGING, V26, P839, DOI 10.1016/j.neurobiolaging.2004.07.012
   Huang M, 2002, J CLIN INVEST, V109, P931, DOI 10.1172/JCI200214685
   ISCHIROPOULOS H, 1992, ARCH BIOCHEM BIOPHYS, V298, P431, DOI 10.1016/0003-9861(92)90431-U
   Kálmán S, 2016, NEUROSCIENCE, V320, P105, DOI 10.1016/j.neuroscience.2016.01.067
   Kuring JK, 2023, J PSYCHIATR RES, V168, P279, DOI 10.1016/j.jpsychires.2023.10.009
   Lu SJ, 2013, COMPR PSYCHIAT, V54, P953, DOI 10.1016/j.comppsych.2013.03.026
   Lynch MD, 2018, J CLIN INVEST, V128, P26, DOI 10.1172/JCI93555
   LYONS CR, 1992, J BIOL CHEM, V267, P6370
   McFarlane AOAC, 2021, J PSYCHIATR RES, V143, P388, DOI 10.1016/j.jpsychires.2021.09.030
   Moodley A, 2023, J PSYCHIATR RES, V165, P105, DOI 10.1016/j.jpsychires.2023.07.018
   Muhie S, 2023, CELL REP MED, V4, DOI 10.1016/j.xcrm.2023.101045
   NATHAN C, 1994, CELL, V78, P915, DOI 10.1016/0092-8674(94)90266-6
   Nejaddehbashi Fereshteh, 2019, Stem Cell Investig, V6, P23, DOI 10.21037/sci.2019.08.05
   Nie QH, 2004, WORLD J GASTROENTERO, V10, P86
   Pace TWW, 2012, BRAIN BEHAV IMMUN, V26, P13, DOI 10.1016/j.bbi.2011.07.232
   Petersen KS, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/6236309
   Pfaffl MW, 2001, NUCLEIC ACIDS RES, V29, DOI 10.1093/nar/29.9.e45
   Pignataro P, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22041605
   Reddy P, 2019, CLIN CHIM ACTA, V496, P35, DOI 10.1016/j.cca.2019.06.019
   Rorabaugh BR, 2020, STRESS, V23, P125, DOI 10.1080/10253890.2019.1641081
   Rosenbaum S, 2015, METABOLISM, V64, P926, DOI [10.1016/j.metabol.2015.04.009, 10.1016/j.metabol.2015.01.016]
   Ryder AL, 2018, CURR PSYCHIAT REP, V20, DOI 10.1007/s11920-018-0977-9
   Schuster R, 2021, IMMUNOL REV, V302, P126, DOI 10.1111/imr.12971
   Seligowski AV, 2022, AM J PSYCHIAT, V179, P814, DOI 10.1176/appi.ajp.21111113
   Shearer JD, 1997, AM J PHYSIOL-ENDOC M, V272, pE181, DOI 10.1152/ajpendo.1997.272.2.E181
   Simard S, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204980
   Sommershof A, 2009, BRAIN BEHAV IMMUN, V23, P1117, DOI 10.1016/j.bbi.2009.07.003
   Song H, 2018, JAMA-J AM MED ASSOC, V319, P2388, DOI 10.1001/jama.2018.7028
   Szondi DC, 2021, FRONT MOL BIOSCI, V8, DOI 10.3389/fmolb.2021.773866
   Tang JS, 2024, J CLIN INVEST, V134, DOI 10.1172/JCI164199
   van den Heuvel LL, 2022, PSYCHONEUROENDOCRINO, V136, DOI 10.1016/j.psyneuen.2021.105619
   van den Heuvel LL, 2020, STRESS, V23, P577, DOI 10.1080/10253890.2020.1724949
   van Leijden MJ, 2018, SOC PSYCH PSYCH EPID, V53, P921, DOI 10.1007/s00127-018-1533-y
   Wang XL, 2018, PSYCHIAT RES, V268, P413, DOI 10.1016/j.psychres.2018.08.028
   Weathers FW, 2018, PSYCHOL ASSESSMENT, V30, P383, DOI 10.1037/pas0000486
   Wen Y, 2012, MOL MED REP, V6, P1140, DOI 10.3892/mmr.2012.1022
   Xia L, 2013, BEHAV BRAIN RES, V256, P472, DOI 10.1016/j.bbr.2013.08.048
   Yu XZ, 2018, NEURON, V99, P1170, DOI 10.1016/j.neuron.2018.08.015
NR 53
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0300-9084
EI 1638-6183
J9 BIOCHIMIE
JI Biochimie
PD OCT
PY 2024
VL 225
BP 10
EP 18
DI 10.1016/j.biochi.2024.05.006
EA MAY 2024
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA J7X9W
UT WOS:001339165900001
PM 38719136
OA hybrid
DA 2025-06-11
ER

PT J
AU Toker, S
   Shirom, A
   Melamed, S
AF Toker, Sharon
   Shirom, Arie
   Melamed, Samuel
TI Depression and the metabolic syndrome: Gender-dependent associations
SO DEPRESSION AND ANXIETY
LA English
DT Article
DE depression; metabolic syndrome; cardiovascular diseases
ID CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; YOUNG-ADULTS; RISK;
   SYMPTOMS; ANXIETY; HEALTHY; PREVALENCE; MORTALITY; ATHEROSCLEROSIS
AB This study was designed to test the extent to which depressive symptoms are associated with the presence of the metabolic syndrome (MS) and each of its components, and whether these relationships are gender dependent. Participants were apparently healthy employed men (N = 2,355) and women (N = 1,525) who underwent a routine health check between the years 2003 and 2005. We used logistic regression analysis, predicting the MS by depressive symptoms, as assessed by the Patient Health Questionnaire, and the following control variables: age, education, smoking status, physical exercise, anxiety, and burnout. As hypothesized, we found that depression among women, but not men, was associated with a 1.94-fold risk of having the MS, and with an elevated risk of having two of its five components: elevated waist circumference (odds ratio, OR = 2.23) and elevated glucose levels (OR = 2.44). In addition, a positive trend was observed toward an association with the other three components: low high-density lipoprotein, hypertension, and elevated triglycerides. Among men depression was associated with elevated waist circumference only (OR = 1. 77). These findings suggest that especially among women, the association between depression and cardiovascular diseases might be linked to metabolic processes. If replicated in longitudinal studies, these findings may have important health-care policy implications with regard to depression management interventions.
C1 [Toker, Sharon; Shirom, Arie] Tel Aviv Univ, Fac Management, IL-69978 Tel Aviv, Israel.
   [Melamed, Samuel] Tel Aviv Univ, Sackler Sch Med, Dept Epidemiol & Prevent Med, IL-69978 Tel Aviv, Israel.
C3 Tel Aviv University; Tel Aviv University; Sackler Faculty of Medicine
RP Toker, S (corresponding author), Tel Aviv Univ, Fac Management, POB 39010, IL-69978 Tel Aviv, Israel.
EM sharon.toker@gmail.com
RI Toker, Sharon/P-5428-2015
OI Toker, Sharon/0000-0001-7621-6607
FU Israel National Institute for Health Policy and Health Services
   Research; Israel Science Foundation [962/02 - 1]
FX The first author acknowledge with thanks a doctoral dissertation grant
   supporting this study, received from the Israel National Institute for
   Health Policy and Health Services Research. We also acknowledge with
   thanks the financial support provided to the study by the Israel Science
   Foundation (Grant 962/02 - 1).
CR Abbey SE, 2000, J PSYCHOSOM RES, V48, P417, DOI 10.1016/S0022-3999(99)00112-9
   Abdi Herve., 2007, ENCY MEASUREMENT STA, P1
   Alexander CM, 2003, DIABETES, V52, P1210, DOI 10.2337/diabetes.52.5.1210
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   Brown ES, 2004, BIOL PSYCHIAT, V55, P1, DOI 10.1016/S0006-3223(03)00473-6
   Cacioppo J.T., 2000, Handbook of Emotions, P173
   Cacioppo JT, 2003, SER AFFECTIVE SCI, P1047
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Corcos M, 2002, BIOMED PHARMACOTHER, V56, P105, DOI 10.1016/S0753-3322(01)00156-1
   Davidson K, 2000, ARCH INTERN MED, V160, P1495, DOI 10.1001/archinte.160.10.1495
   Davidson RJ, 2003, PSYCHOPHYSIOLOGY, V40, P655, DOI 10.1111/1469-8986.00067
   DEPUE RA, 1994, J PERS SOC PSYCHOL, V67, P485, DOI 10.1037/0022-3514.67.3.485
   Dietrich AJ, 2003, J AM BOARD FAM PRACT, V16, P107, DOI 10.3122/jabfm.16.2.107
   Douglas KM, 2004, PSYCHOSOM MED, V66, P679, DOI 10.1097/01.psy.0000138132.66332.85
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   French JR., 1982, MECH JOB STRESS STRA, V7
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   HAUSMAN JA, 1978, ECONOMETRICA, V46, P1251, DOI 10.2307/1913827
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Hintsanen M, 2005, PSYCHOSOM MED, V67, P740, DOI 10.1097/01.psy.0000181271.04169.93
   Hyde JS, 2005, AM PSYCHOL, V60, P581, DOI 10.1037/0003-066X.60.6.581
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Kiecolt-Glaser JK, 2002, ANNU REV PSYCHOL, V53, P83, DOI 10.1146/annurev.psych.53.100901.135217
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Klem ML, 1997, INT J EAT DISORDER, V21, P167, DOI 10.1002/(SICI)1098-108X(199703)21:2<167::AID-EAT7>3.0.CO;2-J
   LAZARUS RS, 2001, EMOTIONS WORK THEORY, P44
   LEDOUX JE, 1995, ANNU REV PSYCHOL, V46, P209, DOI 10.1146/annurev.psych.46.1.209
   Lubetkin EI, 2003, AM J PREV MED, V24, P354, DOI 10.1016/S0749-3797(03)00017-5
   Madden T.E., 2000, GENDER EMOTION SOCIA, P277
   McCaffery JM, 2003, PSYCHOSOM MED, V65, P490, DOI 10.1097/01.PSY.0000041545.52924.82
   McNeill AM, 2005, DIABETES CARE, V28, P385, DOI 10.2337/diacare.28.2.385
   Miranda PJ, 2005, AM HEART J, V149, P33, DOI 10.1016/j.ahj.2004.07.013
   MORGAN RE, 1993, LANCET, V341, P75, DOI 10.1016/0140-6736(93)92556-9
   Nakao M, 2001, JPN HEART J, V42, P739, DOI 10.1536/jhj.42.739
   Nease DE, 2003, J FAM PRACTICE, V52, P118
   Newberg AR, 2006, INT REV PSYCHIATR, V18, P433, DOI 10.1080/09540260600935447
   Niskanen L, 2004, HYPERTENSION, V44, P859, DOI 10.1161/01.HYP.0000146691.51307.84
   Panagiotakos DB, 2004, AM HEART J, V147, P106, DOI 10.1016/S0002-8703(03)00442-3
   Pressman SD, 2005, PSYCHOL BULL, V131, P925, DOI 10.1037/0033-2909.131.6.925
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Regitz-Zagrosek V, 2006, CLIN RES CARDIOL, V95, P136, DOI 10.1007/s00392-006-0351-5
   Rowan PJ, 2005, ANN EPIDEMIOL, V15, P316, DOI 10.1016/j.annepidem.2004.08.006
   Ryff CD, 2003, SER AFFECTIVE SCI, P1083
   Salpeter SR, 2006, DIABETES OBES METAB, V8, P538, DOI 10.1111/j.1463-1326.2005.00545.x
   Scherrer JF, 2003, PSYCHOSOM MED, V65, P548, DOI 10.1097/01.PSY.0000077507.29863.CB
   Shirom A, 2003, ANXIETY STRESS COPIN, V16, P83, DOI 10.1080/1061580021000057059
   Shirota A., 1989, International Journal of Aquaculture and Fisheries Technology, V1, P25
   Simkin-Silverman L R, 1998, Womens Health, V4, P255
   SIMKINSILVERMAN L, 1995, PREV MED, V24, P509, DOI 10.1006/pmed.1995.1081
   SPITZER RL, 1994, JAMA-J AM MED ASSOC, V272, P1749, DOI 10.1001/jama.272.22.1749
   Spitzer RL, 1999, JAMA-J AM MED ASSOC, V282, P1737, DOI 10.1001/jama.282.18.1737
   Steegmans PHA, 2000, PSYCHOSOM MED, V62, P205, DOI 10.1097/00006842-200003000-00009
   Suarez EC, 1999, PSYCHOSOM MED, V61, P273, DOI 10.1097/00006842-199905000-00004
   Suls J, 2005, PSYCHOL BULL, V131, P260, DOI 10.1037/0033-2909.131.2.260
   Wamala SP, 1999, DIABETES CARE, V22, P1999, DOI 10.2337/diacare.22.12.1999
   Weber B, 2000, EXP CLIN ENDOCR DIAB, V108, P187, DOI 10.1055/s-2000-7742
   Williams LS, 2005, STROKE, V36, P635, DOI 10.1161/01.STR.0000155688.18207.33
   Wilson PWF, 2004, CIRCULATION, V110, pE568, DOI 10.1161/01.CIR.0000149077.87074.DE
   Wilson PWF, 2003, CIRCULATION, V108, P1422, DOI 10.1161/01.CIR.0000089505.34741.E5
NR 60
TC 72
Z9 78
U1 1
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1091-4269
EI 1520-6394
J9 DEPRESS ANXIETY
JI Depress. Anxiety
PY 2008
VL 25
IS 8
BP 661
EP 669
DI 10.1002/da.20379
PG 9
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 344BS
UT WOS:000258900900003
PM 17941099
OA gold
DA 2025-06-11
ER

PT J
AU Kang, SW
   Yoo, JS
AF Kang, Se Won
   Yoo, Ji Soo
TI Health-promoting lifestyle and depression in metabolic syndrome patients
   in Korea
SO INTERNATIONAL JOURNAL OF NURSING PRACTICE
LA English
DT Article
DE depression; intervention; lifestyle; metabolic syndrome; nursing
   assessment
ID MIDDLE-AGED MEN; SYMPTOMS; OLDER; REDUCTION; ADHERENCE; BEHAVIORS;
   MORTALITY; PATTERNS; TAIWAN; IMPACT
AB Kang SW, Yoo JS. International Journal of Nursing Practice 2012; 18: 268274 Health-promoting lifestyle and depression in metabolic syndrome patients in Korea This cross-sectional study assessed the association between health-promoting lifestyle and depression in metabolic syndrome patients by using a questionnaire survey in Korea. Data were collected from 195 adults (> 20 years old) with hypertension, dyslipidemia and diabetes. The correlation coefficient (r) between health-promoting lifestyle and depression was -0.309 (P < 0.001), and correlation between individual lifestyle dimensions and depression varied from -0.135 to -0.391. The non-depressed group had higher health-promoting lifestyle scores than the depressed group (P = 0.003). Scores for three dimensions of the health-promoting lifestyle profileself-actualization (P < 0.001), interpersonal support (P = 0.001) and stress management (P = 0.025)were significantly higher in the non-depressed groups. Logistic regression analysis provided an odds ratio of 2.766 (P = 0.003) for health-promoting lifestyle between the two groups. For patients with metabolic syndrome, depression was negatively associated with health-promoting lifestyle and is an important factor affecting health-promoting behaviour.
C1 [Kang, Se Won] Dong Eui Univ, Coll Nursing & Hlth Sci, Pusan 614714, South Korea.
   [Yoo, Ji Soo] Yonsei Univ, Nursing Policy Res Inst, Coll Nursing, Seoul 120749, South Korea.
C3 Dong-Eui University; Yonsei University; Yonsei University Health System
RP Kang, SW (corresponding author), Dong Eui Univ, Coll Nursing & Hlth Sci, 995 Eomgwangno, Pusan 614714, South Korea.
EM swkang75@hotmail.com
RI Kang, sewon/KHX-8924-2024
CR [Anonymous], 2006, 3 KOR NAT HLTH NUTR
   Bonnet F, 2005, J HYPERTENS, V23, P611, DOI 10.1097/01.hjh.0000160219.71350.d2
   Callaghan D, 2006, J HOLIST NURS, V24, P178, DOI 10.1177/0898010106289854
   Chen CM, 2007, J CLIN NURS, V16, P1550, DOI 10.1111/j.1365-2702.2006.01837.x
   Chen SL, 2009, J CLIN NURS, V18, P2234, DOI 10.1111/j.1365-2702.2008.02706.x
   Chilton L, 2006, HOME HLTH CARE MAN P, V18, P378, DOI 10.1177/1084822306288059
   Chon Kyum-Koo., 1992, KOREAN J CLIN PSYCHO, V11, P65
   Ciechanowski PS, 2000, ARCH INTERN MED, V160, P3278, DOI 10.1001/archinte.160.21.3278
   Ferreira SRG, 2008, CAD SAUDE PUBLICA, V24, pS294, DOI 10.1590/S0102-311X2008001400014
   Fisher L, 2001, DIABETES CARE, V24, P1751, DOI 10.2337/diacare.24.10.1751
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Huang Hui-Chuan, 2007, J Nurs Res, V15, P21
   Igna CV, 2008, PSYCHOSOM MED, V70, P960, DOI 10.1097/PSY.0b013e318189a942
   Irace C, 2009, CORONARY ARTERY DIS, V20, P94, DOI 10.1097/MCA.0b013e3283219e76
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Janiszewski PM, 2008, AM J LIFESTYLE MED, V2, P99, DOI 10.1177/1559827607311426
   Jensen Linda Welsch, 2006, Issues Ment Health Nurs, V27, P617, DOI 10.1080/01612840600642919
   KIM CJ, 2008, J KOREAN ACAD ADULT, V20, P33
   Korean Society for the Study of Obesity, 2006, J KOREAN SOC STUDY O, V15, P1
   Kwasniewska Magdalena, 2009, Central European Journal of Public Health, V17, P14
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lin PC, 2007, J CLIN NURS, V16, P1719, DOI 10.1111/j.1365-2702.2007.01743.x
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Rush EC, 2007, ASIA PAC J CLIN NUTR, V16, P671
   Suh YO, 1995, THESIS KYUNGHEE U SE
   Sung MH, 2003, J KOREAN ACAD NURS, V33, P762
   Tsai AG, 2008, OBESITY, V16, P59, DOI 10.1038/oby.2007.8
   WALKER SN, 1988, ADV NURS SCI, V11, P76, DOI 10.1097/00012272-198810000-00008
   WALKER SN, 1987, NURS RES, V36, P76
   Zhu SK, 2004, METABOLISM, V53, P1503, DOI 10.1016/j.metabol.2004.04.017
NR 30
TC 17
Z9 22
U1 1
U2 19
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1322-7114
J9 INT J NURS PRACT
JI Int. J. Nurs. Pract.
PD JUN
PY 2012
VL 18
IS 3
BP 268
EP 274
DI 10.1111/j.1440-172X.2012.02036.x
PG 7
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 946ZH
UT WOS:000304395900008
PM 22621297
DA 2025-06-11
ER

PT J
AU Bijnens, EM
   Derom, C
   Thiery, E
   Martens, DS
   Loos, RJF
   Weyers, S
   Nawrot, TS
AF Bijnens, Esmee M.
   Derom, Catherine
   Thiery, Evert
   Martens, Dries S.
   Loos, Ruth J. F.
   Weyers, Steven
   Nawrot, Tim S.
TI Serum gamma-glutamyl transferase, a marker of alcohol intake, is
   associated with telomere length and cardiometabolic risk in young
   adulthood
SO SCIENTIFIC REPORTS
LA English
DT Article
ID CIGARETTE-SMOKING; OXIDATIVE STRESS; METABOLIC SYNDROME; LIFE;
   GLUTAMYLTRANSFERASE; METAANALYSIS; CONSUMPTION; POPULATION; EXPOSURE;
   DIETARY
AB Studies based on self-reported alcohol consumption and telomere length show inconsistent results. Therefore, we studied the association between gamma-glutamyl transferase (GGT), a widely used biomarker of alcohol intake, and telomere length. The possible health relevance in young adulthood was explored by investigating cardiometabolic risk factors. Mixed modelling was performed to examine GGT and alcohol consumption in association with telomere length in buccal cells of 211 adults between 18 and 30 years old of the East Flanders Prospective Twin Survey. In addition, we investigated the association between GGT and cardiometabolic risk factors; waist circumference, systolic blood pressure, fasting glucose, HDL cholesterol, and triglycerides. Although we did not observe an association between self-reported alcohol consumption and telomere length, our results show that a doubling in serum GGT is associated with 7.80% (95% CI - 13.9 to - 1.2%; p=0.02) shorter buccal telomeres, independently from sex, chronological age, educational level, zygosity and chorionicity, waist-to-hip ratio and smoking. The association between GGT was significant for all five cardiometabolic risk factors, while adjusting for age. We show that GGT, a widely used biomarker of alcohol consumption, is associated with telomere length and with risk factors of cardiometabolic syndrome, despite the young age of this study population.
C1 [Bijnens, Esmee M.; Martens, Dries S.; Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium.
   [Bijnens, Esmee M.; Derom, Catherine; Weyers, Steven] Ghent Univ Hosp, Dept Human Struct & Repair, Corneel Heymanslaan 10, B-9000 Ghent, Belgium.
   [Derom, Catherine] Univ Hosp Leuven, Ctr Human Genet, Herestr 49, B-3000 Leuven, Belgium.
   [Thiery, Evert] Ghent Univ Hosp, Dept Neurol, Corneel Heymanslaan 10, B-9000 Ghent, Belgium.
   [Loos, Ruth J. F.] Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, Mindich Child Hlth & Dev Inst, Genet Obes & Related Metab Traits Program, 1468 Madison Ave, New York, NY 10029 USA.
   [Nawrot, Tim S.] Leuven Univ KU Leuven, Dept Publ Hlth, Kapucijnenvoer 35, B-3000 Leuven, Belgium.
C3 Hasselt University; Ghent University; Ghent University Hospital; KU
   Leuven; University Hospital Leuven; Ghent University; Ghent University
   Hospital; Icahn School of Medicine at Mount Sinai; KU Leuven
RP Bijnens, EM (corresponding author), Hasselt Univ, Ctr Environm Sci, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium.; Bijnens, EM (corresponding author), Ghent Univ Hosp, Dept Human Struct & Repair, Corneel Heymanslaan 10, B-9000 Ghent, Belgium.
EM esmee.bijnens@uhasselt.be
RI Derom, Catherine/HLH-2625-2023; Loos, Ruth/AFU-8669-2022; Odili,
   Augustine/O-2612-2019; Loos, Ruth/Q-2862-2016
OI Nawrot, Tim/0000-0002-3583-3593; Loos, Ruth/0000-0002-8532-5087;
   Bijnens, Esmee/0000-0001-8537-843X; Derom, Catherine/0000-0001-5574-796X
FU EU research council [ERC-2012-StG 310890]; Flemish Scientific Fund (FWO)
   [G073315N, 12X9620N]; Marguerite-Marie Delacroix foundation; Fund of
   Scientific Research Flanders and Twins, a non-profit Association for
   Scientific Research in Multiple Births (Belgium)
FX This investigation is supported by the EU research council "project
   ENVIRONAGE" (ERC-2012-StG 310890), and the Flemish Scientific Fund (FWO,
   G073315N). Dr. Bijnens holds a fellow-ship from the Marguerite-Marie
   Delacroix foundation. Dr. Martens is a postdoctoral fellow of the FWO
   (12X9620N). Since its start, the East Flanders Prospective Twin Survey
   has been partly supported by grants from the Fund of Scientific Research
   Flanders and Twins, a non-profit Association for Scientific Research in
   Multiple Births (Belgium).
CR Adler N, 2013, BRAIN BEHAV IMMUN, V27, P15, DOI 10.1016/j.bbi.2012.08.014
   Astuti Y, 2017, ENVIRON RES, V158, P480, DOI 10.1016/j.envres.2017.06.038
   Bijnens E, 2015, ENVIRON INT, V79, P1, DOI 10.1016/j.envint.2015.02.008
   Bijnens EM, 2017, BMC MED, V15, DOI 10.1186/s12916-017-0964-8
   Blackburn EH, 2001, CELL, V106, P661, DOI 10.1016/S0092-8674(01)00492-5
   Choi KM, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-19700-8
   Chung HS, 2019, J CLIN MED, V8, DOI 10.3390/jcm8060832
   De Meyer T, 2018, J AM COLL CARDIOL, V72, P805, DOI 10.1016/j.jacc.2018.06.014
   de Vos-Houben JMJ, 2012, MECH AGEING DEV, V133, P373, DOI 10.1016/j.mad.2012.04.003
   Derom C, 2019, TWIN RES HUM GENET, V22, P454, DOI 10.1017/thg.2019.64
   Entringer S, 2011, P NATL ACAD SCI USA, V108, pE513, DOI 10.1073/pnas.1107759108
   Finnicum CT, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0170765
   Freitas-Simoes TM, 2016, METABOLISM, V65, P406, DOI 10.1016/j.metabol.2015.11.004
   Gadalla SM, 2010, AGING-US, V2, P867, DOI 10.18632/aging.100235
   Hadzagic-Catibusic Feriha, 2017, Med Arch, V71, P239, DOI 10.5455/medarh.2017.71.239-242
   Hansen TVO, 2007, CANCER EPIDEM BIOMAR, V16, P2072, DOI 10.1158/1055-9965.EPI-07-0611
   Hellemans J, 2007, GENOME BIOL, V8, DOI 10.1186/gb-2007-8-2-r19
   Herrmann M, 2018, CLIN CHEM LAB MED, V56, P1210, DOI 10.1515/cclm-2017-0870
   Kawanishi S, 2004, ANN NY ACAD SCI, V1019, P278, DOI 10.1196/annals.1297.047
   Kunutsor SK, 2015, INT J CLIN PRACT, V69, P136, DOI 10.1111/ijcp.12507
   Kunutsor SK, 2014, ATHEROSCLEROSIS, V236, P7, DOI 10.1016/j.atherosclerosis.2014.06.006
   Latifovic L, 2016, CANCER EPIDEM BIOMAR, V25, P374, DOI 10.1158/1055-9965.EPI-14-1364
   Lee DH, 2004, FREE RADICAL RES, V38, P535, DOI 10.1080/10715760410001694026
   Liu CF, 2012, INT J CLIN PRACT, V66, P692, DOI 10.1111/j.1742-1241.2012.02959.x
   Loos R J, 2001, Twin Res, V4, P356, DOI 10.1375/1369052012524
   Martens DS, 2017, JAMA PEDIATR, V171, P1160, DOI 10.1001/jamapediatrics.2017.3024
   Martens DS, 2016, BMC MED, V14, DOI 10.1186/s12916-016-0689-0
   Martens Dries S, 2016, Curr Environ Health Rep, V3, P258, DOI 10.1007/s40572-016-0098-8
   Mirabello L, 2009, AGING CELL, V8, P405, DOI 10.1111/j.1474-9726.2009.00485.x
   Mundstock E, 2015, OBESITY, V23, P2165, DOI 10.1002/oby.21183
   Nawrot Tim S, 2010, Front Biosci (Elite Ed), V2, P1164
   Needham BL, 2013, SOC SCI MED, V85, P1, DOI 10.1016/j.socscimed.2013.02.023
   Oikawa S, 1999, FEBS LETT, V453, P365, DOI 10.1016/S0014-5793(99)00748-6
   Pavanello S, 2011, INT J CANCER, V129, P983, DOI 10.1002/ijc.25999
   Pieters N, 2016, ENVIRON HEALTH PERSP, V124, P943, DOI 10.1289/ehp.1509728
   Reichert S, 2017, BIOL LETTERS, V13, DOI 10.1098/rsbl.2017.0463
   Révész D, 2014, J CLIN ENDOCR METAB, V99, P4607, DOI 10.1210/jc.2014-1851
   Shalev C, 2013, PSYCHONEUROENDOCRINO, V38, P1835, DOI 10.1016/j.psyneuen.2013.03.010
   Shalev I, 2012, BIOESSAYS, V34, P943, DOI 10.1002/bies.201200084
   Shin C, 2016, ALCOHOL CLIN EXP RES, V40, P765, DOI 10.1111/acer.13005
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Sun Q, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038374
   Vlietinck R, 1986, DETERMINATION ZYGOSI
   von Zglinicki T, 2002, TRENDS BIOCHEM SCI, V27, P339, DOI 10.1016/S0968-0004(02)02110-2
   Weale CJ, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8050464
   Weischer M, 2014, PLOS GENET, V10, DOI 10.1371/journal.pgen.1004191
   Whitfield JB, 2001, CRIT REV CL LAB SCI, V38, P263, DOI 10.1080/20014091084227
   Yang J, 2014, NAT GENET, V46, P100, DOI 10.1038/ng.2876
   Zierer J, 2016, AGING-US, V8, P77, DOI 10.18632/aging.100874
NR 49
TC 7
Z9 8
U1 0
U2 7
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 11
PY 2021
VL 11
IS 1
AR 12407
DI 10.1038/s41598-021-91987-6
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA SV4GJ
UT WOS:000663778500028
PM 34117333
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cheng, S
   Lyass, A
   Massaro, JM
   O'Connor, GT
   Keaney, JF
   Vasan, RS
AF Cheng, Susan
   Lyass, Asya
   Massaro, Joseph M.
   O'Connor, George T.
   Keaney, John F., Jr.
   Vasan, Ramachandran S.
TI Exhaled Carbon Monoxide and Risk of Metabolic Syndrome and
   Cardiovascular Disease in the Community
SO CIRCULATION
LA English
DT Article
DE cardiovascular diseases; carbon monoxide; epidemiology; metabolic
   syndrome; risk factors
ID HEME OXYGENASE; OXIDATIVE STRESS; BILIRUBIN; BLOOD; EXPRESSION;
   EXPOSURE; AIR; AGE; ASSOCIATION; POPULATION
AB Background-Endogenous carbon monoxide (CO) at physiological concentrations is cytoprotective, whereas excess levels reflect underlying oxidative stress, inflammation, and vascular pathology and portend adverse clinical sequelae. However, the relation of exhaled CO to metabolic/vascular risk in the community is unknown.
   Methods and Results-We related exhaled CO, a surrogate measure of blood CO concentration, to the risk of developing new-onset metabolic syndrome and incident cardiovascular disease following 14 943 routine examinations (4139 unique participants; mean age, 46 years, 53% women) in the Framingham Heart Study. Baseline exhaled CO was associated with the presence of cardiometabolic risk factors (including smoking) and prevalent metabolic syndrome (odds ratio, 1.09 per log CO; 95% confidence interval, 1.02 to 1.17; P=0.01). During up to 4 years of follow-up, 1458 participants developed new-onset metabolic syndrome, and 416 experienced a first cardiovascular disease event. Compared with individuals in the lowest quartile of exhaled CO, those in the highest quartile were more likely to develop metabolic syndrome (odds ratio, 1.48; 95% confidence interval, 1.25 to 1.76; P<0.0001) and cardiovascular disease events (hazard ratio, 1.66; 95% confidence interval, 1.14 to 2.40; P=0.008) in multivariable analyses that included adjustment for smoking status.
   Conclusion-In our community-based sample, higher exhaled CO levels predicted the development of metabolic syndrome and future cardiovascular disease events, underscoring the importance of this endogenous second messenger in the pathogenesis of metabolic and vascular risk. (Circulation. 2010;122:1470-1477.)
C1 [Cheng, Susan; Lyass, Asya; O'Connor, George T.; Vasan, Ramachandran S.] Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA.
   [Cheng, Susan] Brigham & Womens Hosp, Dept Med, Div Cardiovasc Med, Boston, MA 02115 USA.
   [Cheng, Susan] Beth Israel Deaconess Med Ctr, Clin Investigator Training Program, Boston, MA 02215 USA.
   [Lyass, Asya] Boston Univ, Dept Math & Stat, Boston, MA 02215 USA.
   [Massaro, Joseph M.] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.
   [O'Connor, George T.] Boston Univ, Sch Med, Ctr Pulm, Boston, MA 02118 USA.
   [Vasan, Ramachandran S.] Boston Univ, Sch Med, Prevent Med & Epidemiol Sect, Dept Med, Boston, MA 02118 USA.
   [Keaney, John F., Jr.] Univ Massachusetts, Sch Med, Dept Med, Boston, MA 02125 USA.
C3 Framingham Heart Study; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard University; Harvard
   University Medical Affiliates; Beth Israel Deaconess Medical Center;
   Boston University; Boston University; Boston University; Boston
   University; University of Massachusetts System; University of
   Massachusetts Boston
RP Vasan, RS (corresponding author), Framingham Heart Dis Epidemiol Study, 73 Mt Wayte Ave,Ste 2, Framingham, MA 01702 USA.
EM vasan@bu.edu
RI Cheng, Chi-An/AAD-7706-2022; Ramachandran, Vasan/Y-2527-2019
OI Cheng, Susan/0000-0002-4977-036X; Ramachandran,
   Vasan/0000-0001-7357-5970; O'Connor, George/0000-0002-6476-3926; Keaney,
   John/0000-0002-0866-1837; Massaro, Joseph/0000-0002-2682-4812
FU National Heart, Lung and Blood Institute's Framingham Heart Study
   [NO1-HC-25195]; American College of Cardiology Foundation/Merck Research
   Fellowship
FX This work was supported in part by the National Heart, Lung and Blood
   Institute's Framingham Heart Study (contract No. NO1-HC-25195) and the
   American College of Cardiology Foundation/Merck Research Fellowship in
   Cardiovascular Disease and Cardiometabolic Disorders (Dr Cheng).
CR [Anonymous], 2000, SAS/STAT User's Guide
   ARIYOSHI T, 1981, J PHARMACOBIO-DYNAM, V4, P664, DOI 10.1248/bpb1978.4.664
   Barañano DE, 2002, P NATL ACAD SCI USA, V99, P16093, DOI 10.1073/pnas.252626999
   Barnes CJ, 1998, AGE, V21, P123, DOI 10.1007/s11357-998-0019-3
   Bauer I, 2009, CRIT CARE, V13, DOI 10.1186/cc7887
   BAYNES JW, 1991, DIABETES, V40, P405, DOI 10.2337/diabetes.40.4.405
   Benjamin EJ, 2007, BMC MED GENET, V8, DOI 10.1186/1471-2350-8-S1-S11
   Biernacki WA, 2001, RESP MED, V95, P1003, DOI 10.1053/rmed.2001.1196
   Chau CK, 2002, ENVIRON INT, V27, P617, DOI 10.1016/S0160-4120(01)00120-9
   COBURN RF, 1967, ACTA MED SCAND, VS, P269
   COX DR, 1972, J R STAT SOC B, V34, P187
   Cunnington AJ, 2002, POSTGRAD MED J, V78, P233, DOI 10.1136/pmj.78.918.233
   DAGOSTINO RB, 1990, STAT MED, V9, P1501, DOI 10.1002/sim.4780091214
   Deedwania PC, 2004, CIRCULATION, V109, P2, DOI 10.1161/01.CIR.0000110642.73995.BF
   Dulak J, 2008, CIRCULATION, V117, P231, DOI 10.1161/CIRCULATIONAHA.107.698316
   Durante W, 2002, VASC MED, V7, P195, DOI 10.1191/1358863x02vm424ra
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hedblad B, 2005, ATHEROSCLEROSIS, V179, P177, DOI 10.1016/j.atherosclerosis.2004.10.005
   Horváth I, 1998, THORAX, V53, P668, DOI 10.1136/thx.53.8.668
   Jones AYM, 2006, SCI TOTAL ENVIRON, V354, P150, DOI 10.1016/j.scitotenv.2005.02.018
   JONES RH, 1958, J LAB CLIN MED, V51, P553
   Kannel W.B., 1987, SOME RISK FACTORS RE
   KANNEL WB, 1979, AM J EPIDEMIOL, V110, P281, DOI 10.1093/oxfordjournals.aje.a112813
   Kharitonov SA, 2001, AM J RESP CRIT CARE, V163, P1693, DOI 10.1164/ajrccm.163.7.2009041
   Lamon BD, 2009, CIRC RES, V105, P775, DOI 10.1161/CIRCRESAHA.109.197434
   NEUZIL J, 1994, J BIOL CHEM, V269, P16712
   Paredi P, 1999, CHEST, V116, P1007, DOI 10.1378/chest.116.4.1007
   Peyton KJ, 2002, BLOOD, V99, P4443, DOI 10.1182/blood.V99.12.4443
   RODKEY FL, 1969, BLOOD-J HEMATOL, V33, P57, DOI 10.1182/blood.V33.1.57.57
   Sabaawy HE, 2001, HYPERTENSION, V38, P210, DOI 10.1161/01.HYP.38.2.210
   Sato S, 2003, CHEST, V124, P1749, DOI 10.1378/chest.124.5.1749
   Scharte M, 2000, BIOCHEM BIOPH RES CO, V267, P423, DOI 10.1006/bbrc.1999.1936
   Siow RCM, 1999, CARDIOVASC RES, V41, P385, DOI 10.1016/S0008-6363(98)00278-8
   STOCKER R, 1987, SCIENCE, V235, P1043, DOI 10.1126/science.3029864
   Togane Y, 2000, AM J PHYSIOL-HEART C, V278, pH623, DOI 10.1152/ajpheart.2000.278.2.H623
   Van Hoydonck PGA, 2001, INT J EPIDEMIOL, V30, P1465
   Wagner CT, 1997, J CLIN INVEST, V100, P589, DOI 10.1172/JCI119569
   Wu LY, 2005, PHARMACOL REV, V57, P585, DOI 10.1124/pr.57.4.3
   YAN SD, 1994, J BIOL CHEM, V269, P9889
   Zayasu K, 1997, AM J RESP CRIT CARE, V156, P1140, DOI 10.1164/ajrccm.156.4.96-08056
   ZHANG J, 1992, J CLIN INVEST, V90, P1193, DOI 10.1172/JCI115980
NR 41
TC 40
Z9 41
U1 1
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD OCT 12
PY 2010
VL 122
IS 15
BP 1470
EP 1477
DI 10.1161/CIRCULATIONAHA.110.941013
PG 8
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 661SS
UT WOS:000282749000010
PM 20876437
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Lien, HC
   Chiang, KJ
   Feng, HP
   Lin, CH
   Chang, YC
   Tzeng, WC
AF Lien, Hsien-Chih
   Chiang, Kai-Jo
   Feng, Hsin-Pei
   Lin, Chia-Huei
   Chang, Yue-Cune
   Tzeng, Wen-Chii
TI Mental Health Nurses' Knowledge of Metabolic Syndrome: A Cross-Sectional
   Study
SO NURSING FORUM
LA English
DT Article
ID CARE
AB Background: Adequate knowledge of the metabolic syndrome is essential for mental health nurses as it enhances their ability to recognize and address the physical needs of individuals diagnosed with serious mental illnesses.Aims: This study investigated the factors influencing the level of metabolic syndrome knowledge among mental health nurses.Methods: A cross-sectional study was conducted with 208 mental health nurses recruited from four hospitals in northern Taiwan, including two regional hospitals, one medical center, and one mental health hospital. Nurses' knowledge was assessed using a validated 20-item self-administered questionnaire covering key aspects of metabolic syndrome, including pathophysiology, diagnostic criteria, and management. The questionnaire demonstrated satisfactory reliability (KR-20 = 0.702) and content validity. Data analysis involved descriptive statistics, independent t-tests, one-way analysis of variance, Pearson correlation coefficient, and generalized linear models to identify predictors of knowledge levels.Results: The overall correct answer rate was 60.1%. Generalized linear modeling demonstrated that nurses' knowledge was significantly associated with their sources of information (B = 1.371, 95% CI = 0.458-2.285, p = 0.003), the type of hospital they worked in (B = -1.027, 95% CI = -2.015 to -0.039, p = 0.042), and working in a community unit (B = 1.975, 95% CI = 0.067-3.883, p = 0.042).Conclusions: Our results indicate that mental health nurses possessed a moderate level of knowledge concerning metabolic syndrome in people diagnosed with serious mental illness. Addressing this gap requires targeted education programs that integrate physical health education into psychiatric care and promote the use of diverse, evidence-based resources tailored to the specific needs of mental health nurses in different settings. Organizational efforts should focus on fostering a supportive culture that enhances access to high-quality resources, encourages interdisciplinary collaboration, and supports continuous professional development.
C1 [Lien, Hsien-Chih; Chiang, Kai-Jo; Tzeng, Wen-Chii] Tri Serv Gen Hosp, Dept Nursing, Taipei City 114202, Taiwan.
   [Feng, Hsin-Pei; Lin, Chia-Huei] Natl Def Med Ctr, Sch Nursing, Taipei City 114201, Taiwan.
   [Chang, Yue-Cune] Tamkang Univ, Dept Math, New Taipei City 251301, Taiwan.
C3 Tri-Service General Hospital; National Defense Medical Center; Tamkang
   University
RP Tzeng, WC (corresponding author), Tri Serv Gen Hosp, Dept Nursing, Taipei City 114202, Taiwan.
EM wctzeng@mail.ndmctsgh.edu.tw
RI Lin, Chia-Huei/GLQ-5499-2022; Tzeng, Wen-Chii/M-4214-2014
OI Chang, Yue-Cune/0000-0002-0224-1268; Tzeng,
   Wen-Chii/0000-0002-4205-896X; Lin, Chia-Huei/0000-0003-3751-602X
FU Tri-Service General Hospital
FX The authors deeply thank all participants who were involved in this
   study. We confirm that no artificial intelligence tools were used in the
   preparation of this manuscript, including planning, analysis, table and
   figure generation, or drafting. All content is the result of the
   authors' intellectual efforts.
CR [Anonymous], 2021, The future of nursing 2020-2030: Charting a path to achieve health equity, DOI [DOI 10.17226/25982, 10.17226/25889]
   Bailey JM, 2019, PREV MED REP, V16, DOI 10.1016/j.pmedr.2019.100969
   Bellass S, 2021, DIABETIC MED, V38, DOI 10.1111/dme.14562
   Bolton PS, 2016, J PSYCHOSOC NURS MEN, V54, P44, DOI 10.3928/02793695-20161026-01
   Bui TNT, 2025, ADM POLICY MENT HLTH, V52, P289, DOI 10.1007/s10488-024-01408-9
   Codazzi V, 2024, ENDOCRINE, V84, P16, DOI 10.1007/s12020-023-03642-x
   Ebel RL., 1991, Essentials of Educational Measurement
   Guijarro SF, 2019, INT J MENT HEALTH NU, V28, P1328, DOI 10.1111/inm.12644
   Fossum M, 2022, WORLDV EVID-BASED NU, V19, P372, DOI 10.1111/wvn.12569
   Havakuk O, 2017, DIABETES METAB SYND, V11, P193, DOI 10.1016/j.dsx.2016.09.005
   Health Promotion Administration, 2023, Manual of Metabolic Syndrome Prevention and Management
   Jabbie L, 2024, INT J MENT HEALTH NU, V33, P309, DOI 10.1111/inm.13253
   Kim JS, 2020, EUR J CANCER CARE, V29, DOI 10.1111/ecc.13227
   Kumar J, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.7737
   Lakew BA, 2023, VASC HEALTH RISK MAN, V19, P637, DOI 10.2147/VHRM.S422339
   Martland R, 2021, J AFFECT DISORDERS, V283, P198, DOI 10.1016/j.jad.2021.01.065
   Matete RP, 2024, SAJP-S AFR J PSYCHI, V30, DOI 10.4102/sajpsychiatry.v30i0.2219
   Miedlich SU, 2024, PLOS ONE, V19, DOI 10.1371/journal.pone.0306798
   National Institute of Mental Health, National Institute of Mental Health under contract No. MH072591
   Park S, 2024, J NURS SCHOLARSHIP, V56, P249, DOI 10.1111/jnu.12946
   Polit D., 2006, Essentials of nursing research, V6
   Saccaro LF, 2024, FRONT PSYCHIATRY, V15, DOI 10.3389/fpsyt.2024.1343427
   See L.C., 2010, Journal of Health Management, V8, P137, DOI DOI 10.29805/JHM.201012.0003
   Serdar CC, 2021, BIOCHEM MEDICA, V31, DOI 10.11613/BM.2021.010502
   Sharrock J, 2022, INT J MENT HEALTH NU, V31, P772, DOI 10.1111/inm.12994
   Smith P, 2023, INT J MENT HEALTH NU, V32, P1289, DOI 10.1111/inm.13160
   Streiner D., 2023, Health Measurement Scales
   Tzeng WC, 2023, INT J MENT HEALTH NU, V32, P199, DOI 10.1111/inm.13076
   Tzeng WC, 2020, INT J MENT HEALTH NU, V29, P254, DOI 10.1111/inm.12670
   Vancampfort D, 2019, AFR HEALTH SCI, V19, P2546, DOI 10.4314/ahs.v19i3.30
   Vincenzi B., 2024, UpToDate
   Watkins A, 2017, FRONT PUBLIC HEALTH, V5, DOI 10.3389/fpubh.2017.00321
   Wong WK, 2022, J PSYCHIATR MENT HLT, V29, P659, DOI 10.1111/jpm.12838
   Yahia N, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-111
   Zhao XF, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1149239
NR 35
TC 0
Z9 0
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0029-6473
EI 1744-6198
J9 NURS FORUM
JI Nurs. Forum
PD DEC 20
PY 2024
VL 2024
AR 2808471
DI 10.1155/nuf/2808471
PG 12
WC Nursing
WE Emerging Sources Citation Index (ESCI)
SC Nursing
GA R2G5L
UT WOS:001389699900001
OA hybrid
DA 2025-06-11
ER

PT J
AU Lee, SY
   Lee, JP
   Lee, JH
   Park, JY
   Kim, EY
AF Lee, Seo-yoon
   Lee, Jung Pyo
   Lee, Jeonghwan
   Park, Jae Yoon
   Kim, Eun Young
TI Association between depressive symptoms and the risk of all-cause and
   cardiovascular mortality among US adults
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Depression; All-cause mortality; Cardiovascular mortality; Sex
   difference; Age difference
ID NATIONAL EPIDEMIOLOGIC SURVEY; METABOLIC SYNDROME; EXCESS MORTALITY;
   MAJOR DEPRESSION; DISEASE; DISORDER; METAANALYSIS; PREVALENCE; ANXIETY;
   HEART
AB Depression is a preventable and treatable mental health condition. Therefore, there are important clinical implications for identifying people with the highest mortality risk in a nationally representative sample. This study included 26,207 participants aged >= 18 years from the 2005-2014 National Health and Nutrition Examination Survey in USA. We investigated the association between depressive symptoms (defined as Patient Health Questionnaire 9 scores >= 10) and all-cause and cardiovascular disease (CVD) mortalities, adjusted for multiple factors (sociodemographic in Model 1, behavioral added in Model 2, and metabolic syndrome added in Model 3) and stratified by age and sex. During an average follow-up of 69.15 months (standard deviation [SD] 34.45), 1872 (7.3%) participants had died (person-years in the non-depressive and depressive groups, 12.12/1000 and 16.43/1000, respectively). Depressive symptoms increased all-cause (crude hazard ratio [HR] 1.37, 95% confidence interval [CI], 1.33-1.58) and CVD mortalities (crude HR 1.64, 95% CI, 1.20-2.24). Although the significance of all-cause mortality and CVD mortality was maintained in Models 1 (HR 1.58 and 2.08) and 2 (HR 1.48 and 1.79), it was not maintained in Model 3. Current smoking and lower physical activity were associated with reduced strength of the association between depression and all-cause mortality risk. The effect of depression on mortality risk was particularly pronounced in middle-aged men and older women. Our findings suggest that depressive symptoms increase mortality risk, even after adjusting for behavioral factors. Depression-induced mortality risk is particularly high among middle-aged men and older women.
C1 [Lee, Seo-yoon] Natl Canc Ctr, Dept Psychiat, 323 Ilsan ro, Goyang Si 10408, Gyeonggi Do, South Korea.
   [Lee, Seo-yoon] Korea Univ, Dept Psychol, 145 Anam ro, Seoul 02841, South Korea.
   [Lee, Jung Pyo; Lee, Jeonghwan] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea.
   [Lee, Jung Pyo; Lee, Jeonghwan] Seoul Natl Univ, Boramae Med Ctr, Dept Internal Med, Seoul, South Korea.
   [Park, Jae Yoon] Dongguk Univ, Ilsan Hosp, Dept Internal Med, Goyang, South Korea.
   [Park, Jae Yoon] Dongguk Univ, Coll Med, Dept Internal Med, Gyeongju, South Korea.
   [Kim, Eun Young] Seoul Natl Univ, Coll Med, Dept Human Syst Med, 101 Daehak ro, Seoul 03080, South Korea.
   [Kim, Eun Young] Seoul Natl Univ, Hlth Care Ctr, Mental Hlth Ctr, 1 Gwanak ro, Seoul 08826, South Korea.
   [Kim, Eun Young] Seoul Natl Univ, Hlth Care Ctr, Mental Hlth Ctr, Dept Psychiat, 63 444 1 Gwanak ro, Seoul 08826, South Korea.
C3 National Cancer Center - Korea (NCC); Korea University; Seoul National
   University (SNU); Seoul National University (SNU); Seoul National
   University Hospital; Dongguk University; NHIS Ilsan Hospital; Dongguk
   University; Seoul National University (SNU); Seoul National University
   (SNU); Seoul National University (SNU)
RP Kim, EY (corresponding author), Seoul Natl Univ, Hlth Care Ctr, Mental Hlth Ctr, Dept Psychiat, 63 444 1 Gwanak ro, Seoul 08826, South Korea.
EM ey00@snu.ac.kr
RI Kim, YoungHwan/B-2395-2013; Lee, Jeonghwan/C-5214-2011; Lee,
   Joo/C-3851-2013
CR Andrea SB, 2016, GEN HOSP PSYCHIAT, V39, P73, DOI 10.1016/j.genhosppsych.2015.11.009
   Anstey KJ, 2002, PSYCHOSOM MED, V64, P880, DOI 10.1097/01.PSY.0000028827.64279.60
   Baldessarini R.J., 1985, Chemotherapy in Psychiatry: Principles and Practice, Vsecond
   Blanco C, 2010, J CLIN PSYCHIAT, V71, P1645, DOI 10.4088/JCP.09m05663gry
   Butnoriene J, 2015, INT J CARDIOL, V190, P360, DOI 10.1016/j.ijcard.2015.04.122
   Cabello M, 2020, J AFFECT DISORDERS, V266, P424, DOI 10.1016/j.jad.2020.01.162
   Chien IC, 2013, J PSYCHOSOM RES, V75, P270, DOI 10.1016/j.jpsychores.2013.06.003
   Chuang CS, 2014, GEN HOSP PSYCHIAT, V36, P497, DOI 10.1016/j.genhosppsych.2014.05.008
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   Cuijpers P, 2002, J AFFECT DISORDERS, V72, P227, DOI 10.1016/S0165-0327(01)00413-X
   Cuijpers P, 2014, AM J PSYCHIAT, V171, P453, DOI 10.1176/appi.ajp.2013.13030325
   Curtin Lester R, 2013, Vital Health Stat 2, P1
   DiMatteo MR, 2000, ARCH INTERN MED, V160, P2101, DOI 10.1001/archinte.160.14.2101
   Fain JA, 2017, DIABETES EDUCATOR, V43, P151, DOI 10.1177/0145721717698651
   Fugger G, 2018, EUR NEUROPSYCHOPHARM, V28, P752, DOI 10.1016/j.euroneuro.2018.03.011
   Galecki P, 2018, PSYCHIATR POL, V52, P437, DOI 10.12740/PP/76863
   Gehi A, 2005, ARCH INTERN MED, V165, P2508, DOI 10.1001/archinte.165.21.2508
   Gilman SE, 2017, CAN MED ASSOC J, V189, pE1304, DOI 10.1503/cmaj.170125
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Goodwin RD, 2022, AM J PREV MED, V63, P726, DOI 10.1016/j.amepre.2022.05.014
   Hare DL, 2014, EUR HEART J, V35, P1365, DOI 10.1093/eurheartj/eht462
   Harris AHS, 2006, J AFFECT DISORDERS, V93, P79, DOI 10.1016/j.jad.2006.02.013
   Hasin DS, 2018, JAMA PSYCHIAT, V75, P336, DOI 10.1001/jamapsychiatry.2017.4602
   Horton NJ, 2001, AM J EPIDEMIOL, V154, P649, DOI 10.1093/aje/154.7.649
   JETTE M, 1990, CLIN CARDIOL, V13, P555, DOI 10.1002/clc.4960130809
   Kawamura TL, 2007, J INVEST MED, V55, P106, DOI 10.2310/6650.2007.06040
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178, DOI 10.4088/JCP.v69n0202
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Kroenke K, 2010, GEN HOSP PSYCHIAT, V32, P345, DOI 10.1016/j.genhosppsych.2010.03.006
   Lepine Jean-Pierre, 2011, Neuropsychiatr Dis Treat, V7, P3, DOI 10.2147/NDT.S19617
   Maes M, 2011, PROG NEURO-PSYCHOPH, V35, P769, DOI 10.1016/j.pnpbp.2010.06.008
   May HT, 2017, EUR HEART J, V3, P296, DOI 10.1093/ehjqcco/qcx017
   Murphy JM, 2008, SOC PSYCH PSYCH EPID, V43, P594, DOI 10.1007/s00127-008-0323-3
   National Institute of Mental Health Office of Science Policy Planning and Communications, 2022, MAJ DEPR
   Penninx BWJH, 2017, NEUROSCI BIOBEHAV R, V74, P277, DOI 10.1016/j.neubiorev.2016.07.003
   Penninx BWJH, 1999, AM J PUBLIC HEALTH, V89, P1346, DOI 10.2105/AJPH.89.9.1346
   Pratt LA, 2016, GEN HOSP PSYCHIAT, V39, P39, DOI 10.1016/j.genhosppsych.2015.12.003
   Rajan S, 2020, JAMA PSYCHIAT, V77, P1052, DOI 10.1001/jamapsychiatry.2020.1351
   ROBINSON RG, 1984, BRIT J PSYCHIAT, V144, P256, DOI 10.1192/bjp.144.3.256
   Rubio JM, 2011, DEPRESS ANXIETY, V28, P622, DOI 10.1002/da.20864
   Ruo B, 2004, AM J CARDIOL, V94, P96, DOI 10.1016/j.amjcard.2004.03.035
   Sanhueza C, 2013, J HUM NUTR DIET, V26, P56, DOI 10.1111/j.1365-277X.2012.01283.x
   Teng PR, 2013, AGING MENT HEALTH, V17, P470, DOI 10.1080/13607863.2012.747081
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
   Van der Kooy K, 2007, INT J GERIATR PSYCH, V22, P613, DOI 10.1002/gps.1723
   Walker ER, 2015, JAMA PSYCHIAT, V72, P334, DOI 10.1001/jamapsychiatry.2014.2502
   Wei JK, 2022, J AFFECT DISORDERS, V300, P189, DOI 10.1016/j.jad.2021.12.104
   Whooley MA, 2008, JAMA-J AM MED ASSOC, V300, P2379, DOI 10.1001/jama.2008.711
   World Health Organization, 2017, WHOMSDMER20172
   World Health Organization, 2005, WHO steps surveillance manual: the who stepwise approach to chronic disease risk factor surveillance
   Wu Q, 2016, MEDICINE, V95, P1, DOI 10.1097/MD.0000000000002815
   Wulsin LR, 1999, PSYCHOSOM MED, V61, P6, DOI 10.1097/00006842-199901000-00003
   Ziegelstein RC, 2000, ARCH INTERN MED, V160, P1818, DOI 10.1001/archinte.160.12.1818
NR 54
TC 21
Z9 21
U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD JUL 13
PY 2023
VL 125
AR 110755
DI 10.1016/j.pnpbp.2023.110755
EA APR 2023
PG 9
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA G7GH0
UT WOS:000990794000001
PM 36958666
DA 2025-06-11
ER

PT J
AU Ali, NH
   Al-Kuraishy, HM
   Al-Gareeb, AI
   Alexiou, A
   Papadakis, M
   Bahaa, MM
   Alibrahim, F
   Batiha, GE
AF Ali, Naif H.
   Al-Kuraishy, Hayder M.
   Al-Gareeb, Ali I.
   Alexiou, Athanasios
   Papadakis, Marios
   Bahaa, Mostafa M.
   Alibrahim, Fawaz
   Batiha, Gaber El-Saber
TI New insight on the potential detrimental effect of metabolic syndrome on
   the Alzheimer disease neuropathology: Mechanistic role
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Review
DE Alzheimer disease; metabolic syndrome; neuroinflammation
ID HYDROGEN-SULFIDE PROTECTS; BRAIN INSULIN-RESISTANCE;
   HIGH-DENSITY-LIPOPROTEIN; AMYLOID-BETA; OXIDATIVE STRESS; CEREBRAL
   HYPOPERFUSION; COGNITIVE FUNCTION; MOUSE MODEL; RISK; ASSOCIATION
AB The metabolic syndrome or syndrome X is a clustering of different components counting insulin resistance (IR), glucose intolerance, visceral obesity, hypertension and dyslipidemia. It has been shown that IR and dysregulation of insulin signalling play a critical role in the development of metabolic syndrome by initiating the pathophysiology of metabolic syndrome through induction of glucolipotoxicity, impairment of glucose disposal and triggering of pro-inflammatory response. Furthermore, metabolic syndrome unfavourably affects the cognitive function and the development of different neurodegenerative diseases such as Alzheimer disease (AD) by inducing oxidative stress, neuroinflammation and brain IR. These changes together with brain IR impair cerebrovascular reactivity leading to cognitive impairment. In addition, metabolic syndrome increases the risk for the development of AD. However, the central mechanisms by which metabolic syndrome amplify AD risk are not completely elucidated. Consequently, this narrative review aims to revise from published articles the association between metabolic syndrome and AD regarding cellular and subcellular pathways. In conclusion, metabolic syndrome is regarded as a potential risk factor for the induction of AD neuropathology by different signalling pathways such as initiation of brain IR, activation of inflammatory signalling pathways and neuroinflammation.
C1 [Ali, Naif H.] Najran Univ, Dept Internal Med, Med Coll, Najran, Saudi Arabia.
   [Al-Kuraishy, Hayder M.] Mustansiriyah Univ, Coll Med, Dept Clin Pharmacol & Med, Baghdad, Iraq.
   [Al-Gareeb, Ali I.] Jabir Ibn Hayyan Med Univ, Najaf, Iraq.
   [Alexiou, Athanasios] Novel Global Community Educ Fdn, Dept Sci & Engn, Hebersham, NSW, Australia.
   [Alexiou, Athanasios] AFNP Med, Dept Res & Dev, Vienna, Austria.
   [Alexiou, Athanasios] Funogen, Dept Res & Dev, Athens 11741, Greece.
   [Alexiou, Athanasios] Chandigarh Univ, Univ Ctr Res & Dev, Mohali, Punjab, India.
   [Papadakis, Marios] Univ Witten Herdecke, Univ Hosp Witten Herdecke, Dept Surg 2, Heusnerstr 40, D-42283 Wuppertal, Germany.
   [Bahaa, Mostafa M.] Horus Univ, Fac Pharm, Pharm Practice Dept, New Damietta, Egypt.
   [Alibrahim, Fawaz] Minist Natl Guard Hlth Affairs, Div Neurol, King Abdulaziz Med City, Riyadh, Saudi Arabia.
   [Batiha, Gaber El-Saber] Damanhour Univ, Fac Vet Med, Dept Pharmacol & Therapeut, Damanhour, Egypt.
C3 Najran University; Mustansiriya University; Jabir Ibn Hayyan University
   for Medical & Pharmaceutical Sciences; Chandigarh University; Witten
   Herdecke University; King Saud Bin Abdulaziz University for Health
   Sciences; Ministry of National Guard - Health Affairs; Egyptian
   Knowledge Bank (EKB); Damanhour University
RP Papadakis, M (corresponding author), Univ Witten Herdecke, Univ Hosp Witten Herdecke, Dept Surg 2, Heusnerstr 40, D-42283 Wuppertal, Germany.
EM drmariospapadakis@gmail.com
RI Papadakis, Marios/AAI-6622-2020; Al-gareeb, Ali/AHD-4577-2022;
   al-kuraishy, hayder/AAE-6673-2019; Alexiou, Athanasios/AAT-8491-2021
OI Alexiou, Athanasios/0000-0002-2206-7236; Papadakis,
   Marios/0000-0002-9020-874X
FU University of Written-Herdeck, Germany.
FX University of Written-Herdeck, Germany.
CR Al-Kuraishy HM, 2018, J ADV PHARM TECHNOL, V9, P80, DOI 10.4103/japtr.JAPTR_273_18
   Al-kuraishy HM, 2023, AGEING RES REV, V91, DOI 10.1016/j.arr.2023.102084
   Al-Kuraishy HM, 2020, BRAIN CIRC, V6, P70, DOI 10.4103/bc.bc_42_19
   Al-Kuraishy HM, 2019, J LAB PHYS, V11, P317, DOI 10.4103/JLP.JLP_123_19
   Alexandre-Santos B, 2022, LIFE SCI, V291, DOI 10.1016/j.lfs.2021.120269
   Alrouji M, 2023, J CELL MOL MED, V27, P1775, DOI 10.1111/jcmm.17784
   Arshad NA, 2018, CNS NEUROL DISORD-DR, V17, P595, DOI 10.2174/1871527317666180724143258
   Aschner M, 2022, CURR NEUROPHARMACOL, V20, P1908, DOI 10.2174/1570159X20666220302101854
   Atti AR, 2019, AM J GERIAT PSYCHIAT, V27, P625, DOI 10.1016/j.jagp.2019.01.214
   Avogaro P., 1967, Acta Diabetologica Latina, V4, P572, DOI 10.1007/BF01544100
   Bates KA, 2017, INT J NEUROSCI, V127, P243, DOI 10.1080/00207454.2016.1182527
   Batiha GE, 2023, INFLAMMOPHARMACOLOGY, V31, P37, DOI 10.1007/s10787-022-01125-5
   Batiha GES, 2023, INFLAMMOPHARMACOLOGY, V31, P1, DOI 10.1007/s10787-022-01087-8
   Bayram P, 2022, IRAN J BASIC MED SCI, V25, P1308, DOI 10.22038/IJBMS.2022.64917.14295
   Beurel E, 2015, PHARMACOL THERAPEUT, V148, P114, DOI 10.1016/j.pharmthera.2014.11.016
   Birulina J, 2024, J HYPERTENS, V42, DOI 10.1097/01.hjh.0001021812.60670.84
   Blasko I, 2011, J NEURAL TRANSM, V118, P663, DOI 10.1007/s00702-011-0599-4
   Branca C, 2017, HUM MOL GENET, V26, P4823, DOI 10.1093/hmg/ddx361
   Butterfield DA, 2020, NEUROBIOL DIS, V138, DOI 10.1016/j.nbd.2020.104795
   Cai ZY, 2017, NEUROCHEM RES, V42, P3446, DOI 10.1007/s11064-017-2391-9
   Calabrese V, 2009, BIOFACTORS, V35, P146, DOI 10.1002/biof.22
   Caron AZ, 2014, FASEB J, V28, P1306, DOI 10.1096/fj.13-243568
   Catrysse L, 2017, TRENDS CELL BIOL, V27, P417, DOI 10.1016/j.tcb.2017.01.006
   Chadt A, 2020, PFLUG ARCH EUR J PHY, V472, P1273, DOI 10.1007/s00424-020-02417-x
   Chauhan Y, 2015, J RECEPT SIG TRANSD, V35, P592, DOI 10.3109/10799893.2015.1030411
   Chen HL, 2023, DIABET METAB SYND OB, V16, P1541, DOI 10.2147/DMSO.S410834
   Cheng PW, 2015, DIABETES, V64, P3413, DOI 10.2337/db14-1439
   Chui HC, 2015, ALZHEIMERS RES THER, V7, DOI 10.1186/s13195-015-0104-7
   Cirino G, 2023, PHYSIOL REV, V103, P31, DOI 10.1152/physrev.00028.2021
   Comas F, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10050633
   Crichton GE, 2014, J INT NEUROPSYCH SOC, V20, P961, DOI 10.1017/S1355617714000885
   Daulatzai MA, 2017, J NEUROSCI RES, V95, P943, DOI 10.1002/jnr.23777
   Emrani S, 2020, ALZHEIMERS RES THER, V12, DOI 10.1186/s13195-020-00712-4
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Fan H, 2013, J BIOMED RES, V27, P296, DOI 10.7555/JBR.27.20120100
   Feng J, 2021, BIOCHEM BIOPH RES CO, V544, P22, DOI 10.1016/j.bbrc.2021.01.069
   Frisardi V, 2010, AGEING RES REV, V9, P399, DOI 10.1016/j.arr.2010.04.007
   Gadhave K, 2021, MED RES REV, V41, P2689, DOI 10.1002/med.21719
   Gali CC, 2019, MOL CELL NEUROSCI, V99, DOI 10.1016/j.mcn.2019.103390
   Gallagher EJ, 2010, MT SINAI J MED, V77, P511, DOI 10.1002/msj.20212
   Galvao F Jr, 2019, AGEING RES REV, V49, P83, DOI 10.1016/j.arr.2018.11.007
   Ghadge AA, 2019, CYTOKINE, V121, DOI 10.1016/j.cyto.2019.154735
   González-Domínguez R, 2015, MOL BIOSYST, V11, P2429, DOI 10.1039/c4mb00747f
   Halle A, 2008, NAT IMMUNOL, V9, P857, DOI 10.1038/ni.1636
   Hishikawa N, 2016, EUR J NEUROL, V23, P339, DOI 10.1111/ene.12845
   Ivanova N, 2020, J NEUROINFLAMM, V17, DOI 10.1186/s12974-020-1698-7
   James AP, 2003, J ALZHEIMERS DIS, V5, P179, DOI 10.3233/JAD-2003-5302
   Kanoski SE, 2010, J ALZHEIMERS DIS, V21, P207, DOI 10.3233/JAD-2010-091414
   KEMP HG, 1973, AM J CARDIOL, V32, P375, DOI 10.1016/S0002-9149(73)80150-X
   Koyama T, 2020, NUTRIENTS, V12, DOI 10.3390/nu12103090
   Kumari R, 2019, DIABETES METAB SYND, V13, P2409, DOI 10.1016/j.dsx.2019.06.005
   Kylin E., 1923, Zentralbl Inn Med, V44, P105
   Kyrtata N, 2021, FRONT NEUROSCI-SWITZ, V15, DOI 10.3389/fnins.2021.626636
   Lahiri DK, 2003, J ALZHEIMERS DIS, V5, P81, DOI 10.3233/JAD-2003-5203
   Lee J, 2018, AGING CELL, V17, DOI 10.1111/acel.12679
   Lemieux I, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113501
   Lennon MJ, 2019, J ALZHEIMERS DIS, V71, P307, DOI 10.3233/JAD-190474
   Leroy K, 2007, NEUROPATH APPL NEURO, V33, P43, DOI 10.1111/j.1365-2990.2006.00795.x
   Liu Y, 2020, J NEUROINFLAMM, V17, DOI 10.1186/s12974-019-1653-7
   Liu YY, 2010, J ALZHEIMERS DIS, V22, P1189, DOI 10.3233/JAD-2010-101002
   Loch RA, 2023, COMPUT STRUCT BIOTEC, V21, P1189, DOI 10.1016/j.csbj.2023.01.022
   Lopez-Rodriguez AB, 2021, ALZHEIMERS DEMENT, V17, P1735, DOI 10.1002/alz.12341
   Lu R, 2021, HUM BRAIN MAPP, V42, P2434, DOI 10.1002/hbm.25377
   Meuret CJ, 2023, ALZHEIMERS RES THER, V15, DOI 10.1186/s13195-023-01239-0
   Michailidis M, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23052687
   Mietelska-Porowska A, 2014, INT J MOL SCI, V15, P4671, DOI 10.3390/ijms15034671
   Misrani A, 2021, FRONT AGING NEUROSCI, V13, DOI 10.3389/fnagi.2021.617588
   Mohamed EA, 2021, J ETHNOPHARMACOL, V267, DOI 10.1016/j.jep.2020.113468
   Mota SI, 2015, BBA-MOL BASIS DIS, V1852, P1428, DOI 10.1016/j.bbadis.2015.03.015
   Nordestgaard LT, 2021, CLIN CHEM, V67, P245, DOI 10.1093/clinchem/hvaa269
   Pal K, 2018, SOC PSYCH PSYCH EPID, V53, P1149, DOI 10.1007/s00127-018-1581-3
   Park YH, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21113879
   Pasquali R, 2006, ANN NY ACAD SCI, V1083, P111, DOI 10.1196/annals.1367.009
   Paul BD, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12051095
   Hernández-Cáceres MP, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00176
   Pecoraro C, 2021, DRUG RESIST UPDATE, V58, DOI 10.1016/j.drup.2021.100779
   Pedersen WA, 2004, NEUROBIOL DIS, V17, P500, DOI 10.1016/j.nbd.2004.08.003
   Plascencia-Villa G, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12081628
   Pláteník J, 2014, PROG NEURO-PSYCHOPH, V50, P83, DOI 10.1016/j.pnpbp.2013.12.001
   Raffaitin C, 2009, DIABETES CARE, V32, P169, DOI 10.2337/dc08-0272
   Razay G, 2007, ARCH NEUROL-CHICAGO, V64, P93, DOI 10.1001/archneur.64.1.93
   Reddy PH, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8050488
   Reitz C, 2010, ARCH NEUROL-CHICAGO, V67, P1491, DOI 10.1001/archneurol.2010.297
   Renis M, 1996, FEBS LETT, V390, P153, DOI 10.1016/0014-5793(96)00647-3
   Sala M, 2014, DIABETES CARE, V37, P493, DOI 10.2337/dc13-1160
   Schindler SE, 2021, NEUROLOGY, V97, pE1823, DOI 10.1212/WNL.0000000000012775
   Schroder JD, 2021, J TRANSL MED, V19, DOI 10.1186/s12967-020-02687-0
   Sharifulina S, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10102655
   Shou J, 2020, DIABETOL METAB SYNDR, V12, DOI 10.1186/s13098-020-0523-x
   Silveira EA, 2021, OBES REV, V22, DOI 10.1111/obr.13088
   Sinatora RV, 2022, METABOLITES, V12, DOI 10.3390/metabo12010073
   Soares E, 2013, NEUROSCIENCE, V250, P565, DOI 10.1016/j.neuroscience.2013.07.055
   Sokolov AS, 2021, AGEING RES REV, V67, DOI 10.1016/j.arr.2021.101262
   Soto M, 2019, P NATL ACAD SCI USA, V116, P6379, DOI 10.1073/pnas.1817391116
   Spinelli M, 2020, VITAM HORM, V114, P281, DOI 10.1016/bs.vh.2020.04.005
   Spinelli M, 2019, FRONT NEUROSCI-SWITZ, V13, DOI 10.3389/fnins.2019.00788
   Strazzullo P, 2003, ANN INTERN MED, V138, P17, DOI 10.7326/0003-4819-138-1-200301070-00007
   Suliga E, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112598
   Sun FJ, 2023, SCI TOTAL ENVIRON, V867, DOI 10.1016/j.scitotenv.2023.161521
   Sun PP, 2022, ANAL CHEM, DOI 10.1021/acs.analchem.2c01850
   Talbot K, 2012, J CLIN INVEST, V122, P1316, DOI 10.1172/JCI59903
   Thambisetty M, 2013, JAMA NEUROL, V70, P1167, DOI 10.1001/jamaneurol.2013.284
   Trevisan K, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/9171424
   Uddin MS, 2019, MOL NEUROBIOL, V56, P2450, DOI 10.1007/s12035-018-1237-z
   Van Zeller M, 2021, J ALZHEIMERS DIS, V83, P939, DOI 10.3233/JAD-210268
   Vandal M, 2014, DIABETES, V63, P4291, DOI 10.2337/db14-0375
   Vanhanen M, 2006, NEUROLOGY, V67, P843, DOI 10.1212/01.wnl.0000234037.91185.99
   Walhovd KB, 2020, NEUROL-GENET, V6, DOI 10.1212/NXG.0000000000000506
   Wang HH, 2020, PEDIATR GASTROENTERO, V23, P189
   Watts GF, 2021, CLIN CHEM, V67, P6, DOI 10.1093/clinchem/hvaa294
   Weihe P, 2019, CURR OBES REP, V8, P472, DOI 10.1007/s13679-019-00357-x
   Wellington CL, 2016, CURR OPIN LIPIDOL, V27, P225, DOI 10.1097/MOL.0000000000000291
   Wieckowska-Gacek A, 2021, AGEING RES REV, V70, DOI 10.1016/j.arr.2021.101397
   Wsiewicz E., 2023, J Educ Health Sport, V38, P129
   Xue P, 2013, DIABETES, V62, P845, DOI 10.2337/db12-0584
   Yates KF, 2012, ARTERIOSCL THROM VAS, V32, P2060, DOI 10.1161/ATVBAHA.112.252759
   Zhao WH, 2019, BIOMED PHARMACOTHER, V118, DOI 10.1016/j.biopha.2019.108940
   Zheng GS, 2019, J BIOMATER TISS ENG, V9, P592, DOI 10.1166/jbt.2019.2066
   Zhou LN, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12030652
   Zuin M, 2021, NUTR METAB CARDIOVAS, V31, P2244, DOI 10.1016/j.numecd.2021.03.020
NR 120
TC 5
Z9 5
U1 4
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1582-1838
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD DEC
PY 2024
VL 28
IS 23
AR e70118
DI 10.1111/jcmm.70118
PG 13
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA O5A3O
UT WOS:001371248600001
PM 39644152
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bojar, I
   Raczkiewicz, D
   Sarecka-Hujar, B
AF Bojar, Iwona
   Raczkiewicz, Dorota
   Sarecka-Hujar, Beata
TI Depression, Metabolic Syndrome, Serum TSH, and Vitamin D Concentrations
   in Rural and Urban Postmenopausal Women
SO MEDICINA-LITHUANIA
LA English
DT Article
DE depression; TSH; metabolic syndrome; vitamin D; post menopause
ID D SUPPLEMENTATION; D-RECEPTOR; SYMPTOMS; ANXIETY; METAANALYSIS;
   PREVALENCE; DISORDER; OBESITY
AB Background and objectives: Depression is a serious problem affecting people worldwide, however it more commonly concerns women. Depression reduces the quality of life and, in many cases, leads to suicide. Numerous new biological factors have been demonstrated to have an impact on the pathogenesis of depression, including vitamin D, thyroid hormones, as well as factors related to heart disease. The aim of the study was to assess the impact of serum thyroid stimulating hormone (TSH) and vitamin D concentrations as well as metabolic syndrome on the severity of depression in Polish postmenopausal women from urban and rural areas. Materials and Methods: The study was conducted in 2018-2019 in the Lublin region, Poland, and comprised 396 postmenopausal women (239 living in rural areas and 157 living in urban areas). Metabolic syndrome criteria according to the International Diabetes Federation and Beck Depression Inventory were used, and laboratory blood tests were performed. Results: A significantly higher percentage of the examined rural residents had moderate or severe depression in comparison to the urban ones (p = 0.049). The examined women from rural areas had a significantly higher serum vitamin D concentration in comparison to the urban ones (p < 0.001). The rural residents more commonly had below-normal levels of serum TSH and less commonly had normal levels in comparison to the urban residents. Metabolic syndrome was found in 70% of the rural residents, and that number was significantly lower in the urban ones (22%, p < 0.001). Conclusions: The severity of depression in postmenopausal Polish women was correlated negatively with the serum TSH concentration in women from rural areas. The severity of depression was increased in urban postmenopausal women with hypertension. No correlation of the depression severity with the serum vitamin D concentration or other criteria of metabolic syndrome was found.
C1 [Bojar, Iwona] Inst Rural Hlth, Dept Womens Hlth, PL-20950 Lublin, Poland.
   [Raczkiewicz, Dorota] SGH Warsaw Sch Econ, Coll Econ Anal, Inst Stat & Demog, PL-02554 Warsaw, Poland.
   [Sarecka-Hujar, Beata] Med Univ Silesia, Fac Pharmaceut Sci Sosnowiec, Dept Basic Biomed Sci, PL-41200 Sosnowiec, Poland.
C3 Institute of Rural Health in Lublin, Poland; Warsaw School of Economics;
   Medical University of Silesia
RP Sarecka-Hujar, B (corresponding author), Med Univ Silesia, Fac Pharmaceut Sci Sosnowiec, Dept Basic Biomed Sci, PL-41200 Sosnowiec, Poland.
EM iwonabojar75@gmail.com; dorota.bartosinska@gmail.com;
   beatasarecka@poczta.onet.pl
RI Raczkiewicz, Dorota/HKV-8966-2023; Bojar, Iwona/S-6029-2018
OI Bojar, Iwona/0000-0002-3171-225X; Raczkiewicz,
   Dorota/0000-0003-3517-6711; Sarecka-Hujar, Beata/0000-0003-0002-8591
CR Anglin RES, 2013, BRIT J PSYCHIAT, V202, P100, DOI 10.1192/bjp.bp.111.106666
   [Anonymous], DEPR FACT SHEET
   Bener A, 2016, ANN MED HEALTH SCI R, V6, P224, DOI 10.4103/amhsr.amhsr_341_15
   Berridge MJ, 2017, PHARMACOL REV, V69, P80, DOI 10.1124/pr.116.013227
   Bromberger JT, 2010, ARCH GEN PSYCHIAT, V67, P598, DOI 10.1001/archgenpsychiatry.2010.55
   Can MS, 2017, PSYCHIAT DANUB, V29, P179
   Cui X, 2015, NEUROSCIENCE, V304, P90, DOI 10.1016/j.neuroscience.2015.07.048
   Dadoniene J, 2018, ADV CLIN EXP MED, V27, P1555, DOI 10.17219/acem/75147
   De Hert M, 2018, DIALOGUES CLIN NEURO, V20, P31, DOI 10.31887/DCNS.2018.20.1/mdehert
   Delgado PL, 2000, J CLIN PSYCHIAT, V61, P7
   Devi B, 2018, INT J REPROD CONTRAC, V7, P5125, DOI [10.18203/2320-1770.ijrcog20184979, DOI 10.18203/2320-1770.IJRCOG20184979]
   Du FM, 2019, J INT MED RES, V47, P3040, DOI 10.1177/0300060519851624
   Eyles DW, 2005, J CHEM NEUROANAT, V29, P21, DOI 10.1016/j.jchemneu.2004.08.006
   Ferrari AJ, 2013, PSYCHOL MED, V43, P471, DOI 10.1017/S0033291712001511
   Fischer S, 2018, DEPRESS ANXIETY, V35, P98, DOI 10.1002/da.22692
   Foltyn Wanda, 2002, Psychiatr Pol, V36, P281
   Freeman EW, 2014, JAMA PSYCHIAT, V71, P36, DOI 10.1001/jamapsychiatry.2013.2819
   García-Toro M, 2016, J AFFECT DISORDERS, V194, P105, DOI 10.1016/j.jad.2015.12.064
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Gowda U, 2015, NUTRITION, V31, P421, DOI 10.1016/j.nut.2014.06.017
   Libuda L, 2019, NUTRIENTS, V11, DOI 10.3390/nu11051085
   Lichtman JH, 2014, CIRCULATION, V129, P1350, DOI 10.1161/CIR.0000000000000019
   Loh HH, 2019, BMC PSYCHIATRY, V19, DOI 10.1186/s12888-018-2006-2
   Malacara JM, 2002, MATURITAS, V43, P11, DOI 10.1016/S0378-5122(02)00077-4
   Mannan M, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0157240
   Marsh WK, 2017, J PSYCHIATR RES, V95, P48, DOI 10.1016/j.jpsychires.2017.07.021
   Martin JC, 2017, NUTRIENTS, V9, DOI 10.3390/nu9060586
   Mason C, 2016, PREV MED, V93, P166, DOI 10.1016/j.ypmed.2016.09.035
   Milaneschi Y, 2014, MOL PSYCHIATR, V19, P444, DOI 10.1038/mp.2013.36
   Mohammad MYH, 2019, J FAM MED PRIM CARE, V8, P2708, DOI 10.4103/jfmpc.jfmpc_456_19
   Mulhall S, 2018, MATURITAS, V108, P7, DOI 10.1016/j.maturitas.2017.11.005
   Nemati A., 2008, Journal of Biological Sciences, V8, P196
   Guimaraes JMN, 2009, J AFFECT DISORDERS, V117, P120, DOI 10.1016/j.jad.2008.12.012
   Nurbazlin M, 2013, ASIA PAC J CLIN NUTR, V22, P391, DOI 10.6133/apjcn.2013.22.3.15
   Olvera RL, 2015, J CLIN PSYCHIAT, V76, pE1300, DOI 10.4088/JCP.14m09118
   Pan A, 2009, J AFFECT DISORDERS, V118, P240, DOI 10.1016/j.jad.2009.02.002
   Prattala R, 2007, EUR J PUBLIC HEALTH, V17, P520, DOI 10.1093/eurpub/ckl265
   Repousi N, 2018, J AFFECT DISORDERS, V237, P56, DOI 10.1016/j.jad.2018.04.102
   Steinberg EM, 2008, J CLIN PSYCHIAT, V69, P973, DOI 10.4088/JCP.v69n0614
   Talaei A, 2017, BMC PSYCHIATRY, V17, DOI 10.1186/s12888-017-1478-9
   Tang RY, 2019, FERTIL STERIL, V112, P1160, DOI 10.1016/j.fertnstert.2019.08.005
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Whooley MA, 2013, ANNU REV CLIN PSYCHO, V9, P327, DOI 10.1146/annurev-clinpsy-050212-185526
   Yoo T, 2018, PSYCHIAT INVEST, V15, P396, DOI 10.30773/pi.2017.08.30
NR 44
TC 6
Z9 6
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD OCT
PY 2020
VL 56
IS 10
AR 511
DI 10.3390/medicina56100511
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ON7SU
UT WOS:000586896500001
PM 33008063
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jood, K
   Redfors, P
   Rosengren, A
   Blomstrand, C
   Jern, C
AF Jood, Katarina
   Redfors, Petra
   Rosengren, Annika
   Blomstrand, Christian
   Jern, Christina
TI Self-perceived psychological stress and ischemic stroke: a case-control
   study
SO BMC MEDICINE
LA English
DT Article
ID MIDDLE-AGED MEN; CORONARY-ARTERY DISEASE; RISK-FACTORS;
   CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; METABOLIC SYNDROME;
   PROSPECTIVE COHORT; LIFE EVENTS; HEART; ATHEROSCLEROSIS
AB Background: A growing body of evidence suggests that psychological stress contributes to coronary artery disease. However, associations between stress and stroke are less clear. In this study, we investigated the possible association between ischemic stroke and self-perceived psychological stress, as measured by a single-item questionnaire, previously reported to be associated with myocardial infarction.
   Methods: In the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS), 600 consecutive patients with acute ischemic stroke (aged 18 to 69 years) and 600 age-matched and sex-matched population controls were recruited. Ischemic stroke subtype was determined according to Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria. Self-perceived psychological stress preceding stroke was assessed retrospectively using a single-item questionnaire.
   Results: Permanent self-perceived psychological stress during the last year or longer was independently associated with overall ischemic stroke (multivariate adjusted odds ratio (OR) 3.49, 95% confidence interval (CI) 2.06 to 5.93). Analyses by stroke subtype showed that this association was present for large vessel disease (OR 3.91, 95% CI 1.58 to 9.67), small vessel disease (OR 3.20, 95% CI 1.64 to 6.24), and cryptogenic stroke (OR 4.03, 95% CI 2.34 to 6.95), but not for cardioembolic stroke (OR 1.48, 95% CI 0.64 to 3.39).
   Conclusion: In this case-control study, we found an independent association between self-perceived psychological stress and ischemic stroke. A novel finding was that this association differed by ischemic stroke subtype. Our results emphasize the need for further prospective studies addressing the potential role for psychological stress as a risk factor for ischemic stroke. In such studies ischemic stroke subtypes should be taken into consideration.
C1 [Jood, Katarina; Redfors, Petra; Blomstrand, Christian; Jern, Christina] Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Gothenburg, Sweden.
   [Rosengren, Annika] Sahlgrens Univ Hosp, Dept Med, Gothenburg, Sweden.
   [Jern, Christina] Sahlgrens Univ Hosp, Dept Clin Genet, Gothenburg, Sweden.
C3 University of Gothenburg; Sahlgrenska University Hospital; Sahlgrenska
   University Hospital
RP Jood, K (corresponding author), Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Gothenburg, Sweden.
EM katarina.jood@neuro.gu.se; petra.redfors@vgregion.se;
   annika.rosengren@hjl.gu.se; christian.blomstrand@neuro.gu.se;
   christina.jern@neuro.gu.se
OI Blomstrand, Christian/0000-0003-3503-860X
FU Swedish Research Council [VR 2007-2927]; Swedish Heart-Lung Foundation
   [20070404]; Swedish state under the LUA/ALF agreement [ALFGBG 11206];
   Health and Medical Care Executive Board of the Region Vastra Gotaland;
   Swedish Stroke Association; Goteborg Medical Society; Swedish Society of
   Medicine; Goteborg Foundation for Neurological Research; Rune and Ulla
   Amlovs Foundation for Neurological Research; John and Brit Wennerstrom
   Foundation for Neurological Research; The Per-Olof Ahl Foundation for
   Research; Yogve Land Foundation for Neurological Research; Pfizer
FX The present study was supported by the Swedish Research Council (VR
   2007-2927), the Swedish Heart-Lung Foundation (20070404), grants from
   the Swedish state under the LUA/ALF agreement (ALFGBG 11206), the Health
   and Medical Care Executive Board of the Region Vastra Gotaland, the
   Swedish Stroke Association, the Goteborg Medical Society, the Swedish
   Society of Medicine, the Goteborg Foundation for Neurological Research,
   the Rune and Ulla Amlovs Foundation for Neurological Research, the John
   and Brit Wennerstrom Foundation for Neurological Research, The Per-Olof
   Ahl Foundation for Research regarding Cerebrovascular diseases, the
   Yogve Land Foundation for Neurological Research, and a research grant
   from Pfizer (KJ). The funding sources did not participate in the design
   or conduct of the study; collection, management, analysis, or
   interpretation of the data; or preparation, review, or approval of the
   manuscript.
CR ADAMS HP, 1993, STROKE, V24, P35, DOI 10.1161/01.STR.24.1.35
   ANDREPETERSSON L, 1914, INT J BEHAV MED, V10, P79
   Black PH, 2003, BRAIN BEHAV IMMUN, V17, P350, DOI 10.1016/S0889-1591(03)00048-5
   Engström G, 2004, CEREBROVASC DIS, V18, P318, DOI 10.1159/000080770
   Gallo WT, 2004, AM J IND MED, V45, P408, DOI 10.1002/ajim.20004
   Ghiadoni L, 2000, CIRCULATION, V102, P2473, DOI 10.1161/01.CIR.102.20.2473
   HARMSEN P, 1990, STROKE, V21, P223, DOI 10.1161/01.STR.21.2.223
   Hemingway H, 1999, BMJ-BRIT MED J, V318, P1460, DOI 10.1136/bmj.318.7196.1460
   HOUSE A, 1990, J NEUROL NEUROSUR PS, V53, P1024, DOI 10.1136/jnnp.53.12.1024
   Iso H, 2002, CIRCULATION, V106, P1229, DOI 10.1161/01.CIR.0000028145.58654.41
   Jood K, 2005, STROKE, V36, P1383, DOI 10.1161/01.STR.0000169944.46025.09
   Kario K, 2003, HYPERTENS RES, V26, P355, DOI 10.1291/hypres.26.355
   Kim JS, 1998, EUR NEUROL, V39, P168, DOI 10.1159/000007928
   KLEINMAN Y, 1992, NEUROLOGY, V42, P2225, DOI 10.1212/WNL.42.11.2225
   Macko RF, 1996, STROKE, V27, P1999, DOI 10.1161/01.STR.27.11.1999
   May M, 2002, STROKE, V33, P7, DOI 10.1161/hs0102.100529
   McEwen BS, 1998, ANN NY ACAD SCI, V840, P33, DOI 10.1111/j.1749-6632.1998.tb09546.x
   Möller J, 2005, J EPIDEMIOL COMMUN H, V59, P23, DOI 10.1136/jech.2003.019349
   Öhlin B, 2004, EUR HEART J, V25, P867, DOI 10.1016/j.ehj.2004.03.003
   Orth-Gomér K, 2005, BIOL PSYCHOL, V69, P57, DOI 10.1016/j.biopsycho.2004.11.005
   Pancioli AM, 1998, JAMA-J AM MED ASSOC, V279, P1288, DOI 10.1001/jama.279.16.1288
   ROSENGREN A, 1991, AM J CARDIOL, V68, P1171, DOI 10.1016/0002-9149(91)90189-R
   Rosengren A, 2004, LANCET, V364, P953, DOI 10.1016/S0140-6736(04)17019-0
   Rosmond R, 2005, PSYCHONEUROENDOCRINO, V30, P1, DOI 10.1016/j.psyneuen.2004.05.007
   Rozanski A, 1999, CIRCULATION, V99, P2192, DOI 10.1161/01.CIR.99.16.2192
   Salaycik KJ, 2007, STROKE, V38, P16, DOI 10.1161/01.STR.0000251695.39877.ca
   Samuelsson H, 2002, J INT NEUROPSYCH SOC, V8, P382, DOI 10.1017/S1355617702813194
   Samuelsson H, 1996, CLIN NEUROPSYCHOL, V10, P15, DOI 10.1080/13854049608406659
   Surtees PG, 2008, NEUROLOGY, V70, P788, DOI 10.1212/01.wnl.0000304109.18563.81
   Surtees PG, 2007, STROKE, V38, P1447, DOI 10.1161/STROKEAHA.106.473116
   Truelsen T, 2003, STROKE, V34, P856, DOI 10.1161/01.STR.0000062345.80774.40
   von Känel R, 2001, PSYCHOSOM MED, V63, P531, DOI 10.1097/00006842-200107000-00003
   Wolff B, 2005, HEART, V91, P460, DOI 10.1136/hrt.2003.031088
   Yoon SS, 2001, STROKE, V32, P1926, DOI 10.1161/01.STR.32.8.1926
NR 34
TC 67
Z9 78
U1 2
U2 14
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1741-7015
J9 BMC MED
JI BMC Med.
PD OCT 1
PY 2009
VL 7
AR 53
DI 10.1186/1741-7015-7-53
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA 512GW
UT WOS:000271235300001
PM 19796376
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kim, MK
   Park, HJ
   Lee, KJ
AF Kim, Mi-Kyung
   Park, Hyo Jin
   Lee, Kyung Ju
TI Living lab modelling as a pilot study assessing the potential
   psychological health benefits of forest environment for cancer survivors
SO OBSTETRICS & GYNECOLOGY SCIENCE
LA English
DT Article
DE Forests; Relaxation therapy; Cancer survivors; Quality of life;
   Psychological well-being
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; PREVALENCE; THERAPY
AB Objective To evaluate the physiological and psychological changes in cancer survivors who engage in repeated forest therapy in a living environment. Methods This study included stay-based forest therapy for female cancer survivors aged >= 40 years. The program was conducted in two cycles, each spanning 3 weeks and consisting of a 2-night, 3-day stay, followed by daily life integration. The cycles were repeated from July 2, 2022, to August 18, 2022. Participant assessment included standard physical health parameters and a questionnaire on general characteristics, lifestyle habits, stress levels, and health status. Results Thirty-seven female cancer survivors participated in the forest healing program, 56.8% of whom had a history of breast cancer. The median body mass index (BMI) was 23.80 kg/m 2 (range, 21.00-25.60). More than half of the patients reported mild-to-moderate fatigue, chronic pain, and mild-to-moderate depression (81%, 65%, and 73%, respectively). After two cycles of forest therapy, no significant differences were observed in terms of fatigue, pain, or BMI levels. However, significant improvements were found in quality of life measures, particularly the psychological quality of life (mean score 12.54 at baseline vs. 13.48 after cycle 2; P=0.007). Positive improvements were also observed in terms of stress (mean score 17.03 vs. 13.76; P=0.002) and depression (mean score 8.35 vs. 6.11; P=0.002) levels. Conclusion Our forest-healing program demonstrated that nature-based therapies improve the mental health and quality of life of female cancer survivors, suggesting the need for further research on nature-based interventions to better support cancer survivors.
C1 [Kim, Mi-Kyung] Ewha Womans Univ, Mokdong Hosp, Coll Med, Dept Obstet & Gynecol, Seoul 158710, South Korea.
   [Park, Hyo Jin] Ewha Womans Univ, Seoul Hosp, Coll Med, Dept Family Med, Seoul, South Korea.
   [Lee, Kyung Ju] Natl Rehabil Ctr, Dept Womens Rehabil, 58 Samgaksan Ro, Seoul 01022, South Korea.
C3 Ewha Womans University; Ewha Womans University
RP Lee, KJ (corresponding author), Natl Rehabil Ctr, Dept Womens Rehabil, 58 Samgaksan Ro, Seoul 01022, South Korea.
EM drlkj4094@korea.kr
RI Lee, Kyung Ju/AFL-9687-2022; Kim, Ee-Kyung/AAA-1068-2022
FU Korea Forestry Promotion Institute [2021384A00-2123-0101]
FX This research was funded by the Korea Forestry Promotion Institute
   (grant number: 2021384A00-2123-0101) .
CR Andrykowski Michael A, 2008, Semin Oncol Nurs, V24, P193, DOI 10.1016/j.soncn.2008.05.007
   Anundi H, 2023, FORESTS, V14, DOI 10.3390/f14020333
   Baydoun M, 2021, PATIENT PREFER ADHER, V15, P1225, DOI 10.2147/PPA.S267064
   Blaschke S, 2017, BMC CANCER, V17, DOI 10.1186/s12885-017-3366-6
   Buttros DDB, 2013, MENOPAUSE, V20, P448, DOI 10.1097/gme.0b013e318272bd4a
   Debela DT, 2021, SAGE OPEN MED, V9, DOI 10.1177/20503121211034366
   Dunsky A, 2014, EUR REV AGING PHYS A, V11, P149, DOI 10.1007/s11556-014-0139-y
   Friedenreich CM, 2020, JNCI CANCER SPECT, V4, DOI 10.1093/jncics/pkz080
   Gebert P, 2021, BMC MED RES METHODOL, V21, DOI 10.1186/s12874-021-01259-0
   Hui D, 2013, CANCER-AM CANCER SOC, V119, P1098, DOI 10.1002/cncr.27854
   Jung HS, 2012, DIABETES RES CLIN PR, V95, P275, DOI 10.1016/j.diabres.2011.08.029
   Kanjak J, 2022, OBSTET GYNECOL SCI, V65, P244, DOI 10.5468/ogs.22037
   Tran KB, 2022, LANCET, V400, P563, DOI 10.1016/S0140-6736(22)01438-6
   Kim H, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17186548
   Kim M, 2019, CANCER EPIDEMIOL, V58, P130, DOI 10.1016/j.canep.2018.12.006
   Lawton E, 2017, FRONT PSYCHOL, V8, DOI 10.3389/fpsyg.2017.01058
   Lee BJ, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-89422-x
   Li QG, 2022, CANCERS, V14, DOI 10.3390/cancers14235760
   Liu ZY, 2022, J TRANSL MED, V20, DOI 10.1186/s12967-022-03584-4
   McDonough MH, 2021, J CANCER SURVIV, V15, P713, DOI 10.1007/s11764-020-00963-y
   Miller KD, 2022, CA-CANCER J CLIN, V72, P409, DOI 10.3322/caac.21731
   Min SK, 2002, QUAL LIFE RES, V11, P593, DOI 10.1023/A:1016351406336
   Niedzwiedz CL, 2019, BMC CANCER, V19, DOI 10.1186/s12885-019-6181-4
   Oh B, 2017, ENVIRON HEALTH PREV, V22, DOI 10.1186/s12199-017-0677-9
   Oh CM, 2016, CANCER RES TREAT, V48, P436, DOI 10.4143/crt.2016.089
   Oh H, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00666
   Park S, 2019, ANN INTERN MED, V171, P875, DOI 10.7326/M19-0563
   Park SH, 2014, APPL NURS RES, V27, P219, DOI 10.1016/j.apnr.2014.01.004
   Piva G, 2024, REV ENVIRON HEALTH, V39, P121, DOI 10.1515/reveh-2022-0093
   Pyo Hong Jin, 2013, [Mood and Emotion, 우울조울병], V11, P44
   Reed DL, 2016, J CLIN SLEEP MED, V12, P263, DOI 10.5664/jcsm.5498
   Salvador C, 2022, COMPLEMENT THER CLIN, V49, DOI 10.1016/j.ctcp.2022.101639
   Shim SR, 2022, FORESTS, V13, DOI 10.3390/f13122029
   Tabrizi FM, 2016, PSYCHO-ONCOLOGY, V25, P1057, DOI 10.1002/pon.4169
   김성건, 2015, [JOURNAL OF THE KOREAN NEUROPSYCHIATRIC ASSOCIATION, 신경정신의학], V54, P84
   Timko Olson Erica R, 2023, Int J Environ Res Public Health, V20, DOI 10.3390/ijerph20032376
   Tong CKW, 2020, CURR TREAT OPTION ON, V21, DOI 10.1007/s11864-020-00752-w
   Van Leeuwen M, 2018, HEALTH QUAL LIFE OUT, V16, DOI 10.1186/s12955-018-0920-0
   Wang JW, 2015, QUAL LIFE RES, V24, P2815, DOI 10.1007/s11136-015-1021-8
   Yun BS, 2023, OBSTET GYNECOL SCI, V66, P545, DOI 10.5468/ogs.23208
NR 40
TC 0
Z9 0
U1 0
U2 3
PU Korean Soc Obstetrics and Gynecology (KSOG)
PI Seoul
PA 4th Floor, 36 Gangnam-daero 132-gil, Gangnam-gu, Seoul, SOUTH KOREA
SN 2287-8572
EI 2287-8580
J9 OBSTET GYNECOL SCI
JI Obstet. Gynecol. Sci.
PD JUL
PY 2024
VL 67
IS 4
BP 404
EP 413
DI 10.5468/ogs.24035eISSN2287-8580
PG 10
WC Obstetrics & Gynecology
WE Emerging Sources Citation Index (ESCI)
SC Obstetrics & Gynecology
GA YI5L2
UT WOS:001267873100005
DA 2025-06-11
ER

PT J
AU Flynn, M
   Houtjes, W
   Merks, A
   Van Mierlo, A
   Van de Wetering, B
AF Flynn, M.
   Houtjes, W.
   Merks, A.
   Van Mierlo, A.
   Van de Wetering, B.
TI Metabolic syndrome in mental health and addiction treatment: a
   quantitative study
SO JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING
LA English
DT Article
DE Metabolic syndrome; addiction; dual diagnosis; mental health;
   schizophrenia
ID SCHIZOPHRENIA; MORTALITY; OBESITY; RISK
AB Accessible summary Patients with mental illnesses have been found to shorter life expectancy due to an increased risk of heart disease. Some medication used to treat mental illnesses have been linked to weight gain and other physical change that make patients susceptible to heart disease. In order to reduce this risk it is important that health professionals regularly measure and monitor signs of these physical changes. This research has found that measuring both waist circumference and blood pressure of patients is a safe and reliable way to way to monitor patients.
   AbstractTo identify if combined blood pressure and waist circumference measurements are reliable predictor of metabolic syndrome, a descriptive correlational design was used to examine the sensitivity and specificity of screening techniques used to detect metabolic syndrome. Data were collected regarding waist circumference, body mass index, blood pressure, fasting blood glucose, triglycerides and high-density lipoproteins. Blood pressure and waist circumference measurements demonstrated high significance, sensitivity and specificity as screening instruments for metabolic syndrome. Combined waist circumference and blood pressure measurements may be clinically useful for a quick and reliable detection of metabolic syndrome in patients with addiction and comorbid mental health problems.
C1 [Flynn, M.] Bouman GGZ, Inst Addict & Mental Hlth Care, Community Care Team FACT Feijenoord, NL-3035 HC Rotterdam, Netherlands.
   [Van Mierlo, A.] Bouman GGZ, Dept Educ & Training, Inst Addict & Mental Hlth Care, NL-3035 HC Rotterdam, Netherlands.
   [Van de Wetering, B.] Inst Addict & Mental Hlth Care, Rotterdam, Netherlands.
   [Houtjes, W.] Inst Educ Adv Nurse Practitioners Mental Hlth, Utrecht, Netherlands.
   [Merks, A.] Ermergis, Expert Ctr, Goes, Netherlands.
RP Flynn, M (corresponding author), Bouman GGZ, FACT Noord, Zaagmolenstr 60-62, NL-3035 HC Rotterdam, Netherlands.
EM m.flynn@boumanggz.nl
CR [Anonymous], 2002, 3 NAT CHOL ED PROGR
   [Anonymous], 2006, The IDF Consensus Worldwide Definition of the Metabolic Syndrome
   Brown S, 1997, BRIT J PSYCHIAT, V171, P502, DOI 10.1192/bjp.171.6.502
   Cerit C., 2008, Turk J Psychiatry, V19, P1
   Cohn T, 2004, CAN J PSYCHIAT, V49, P753, DOI 10.1177/070674370404901106
   De Hert M, 2009, WORLD PSYCHIATRY, V8, P15
   Dixon L, 1999, J NERV MENT DIS, V187, P496, DOI 10.1097/00005053-199908000-00006
   Hansen V, 2001, BRIT J PSYCHIAT, V179, P438, DOI 10.1192/bjp.179.5.438
   Heiskanen T, 2003, J CLIN PSYCHIAT, V64, P575, DOI 10.4088/JCP.v64n0513
   Laursen TM, 2011, SCHIZOPHR RES, V131, P101, DOI 10.1016/j.schres.2011.06.008
   Lindenmayer JP, 2003, AM J PSYCHIAT, V160, P290, DOI 10.1176/appi.ajp.160.2.290
   Meyer JM, 2005, SCHIZOPHR RES, V80, P9, DOI 10.1016/j.schres.2005.07.015
   National Institute for Health and Clinical Excellence, 2011, HYPERTENSION
   Olfson M, 2006, AM J PSYCHIAT, V163, P1821, DOI 10.1176/appi.ajp.163.10.1821
   Prussian KH., 2007, JNP, V3, P229
   Straker D, 2005, AM J PSYCHIAT, V162, P1217, DOI 10.1176/appi.ajp.162.6.1217
   Tirupati S, 2007, AUST NZ J PSYCHIAT, V41, P606, DOI 10.1080/00048670701392841
   Weiden PJ, 2004, SCHIZOPHR RES, V66, P51, DOI 10.1016/S0920-9964(02)00498-X
NR 18
TC 1
Z9 1
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1351-0126
EI 1365-2850
J9 J PSYCHIATR MENT HLT
JI J. Psychiatr. Ment. Health Nurs.
PD FEB
PY 2015
VL 22
IS 1
BP 15
EP 19
DI 10.1111/jpm.12166
PG 5
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA CA2AO
UT WOS:000348711600003
PM 25376964
DA 2025-06-11
ER

PT J
AU Hoffmann, MS
   Brunoni, AR
   Stringaris, A
   Viana, MC
   Lotufo, PA
   Benseñor, IM
   Salum, GA
AF Hoffmann, Mauricio Scopel
   Brunoni, Andre Russowsky
   Stringaris, Argyris
   Viana, Maria Carmen
   Lotufo, Paulo Andrade
   Bensenor, Isabela Martins
   Salum, Giovanni Abrahao
TI Common and specific aspects of anxiety and depression and the metabolic
   syndrome
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Structural equation model; Diabetes mellitus; Obesity; Hypertension;
   Dyslipidemia; Negative affect; HiTOP
ID CLINICAL INTERVIEW SCHEDULE; STANDARDIZED ASSESSMENT; PSYCHIATRIC
   MORBIDITY; GENERAL FACTOR; CIS-R; ASSOCIATION; ADULTS; PSYCHOPATHOLOGY;
   NEUROECONOMICS; METAANALYSIS
AB Introduction: The associations of anxiety and depression with metabolic syndrome (MetS) are not consistent across studies. Anxiety and depression are highly correlated and traditional methods don?t take the structure of this correlation into account. Our aim is to disentangle the relationship of these emotional conditions with MetS, using bifactor models, modelling both general and specific aspects between anxiety and depression. Methods: Bifactor models were tested using the baseline data from the Brazilian Longitudinal Study of Adult Health (n = 13,584). Anxiety and depression were accessed with the Clinical Interview Schedule - Revised. MetS was measured through assessment of its continuous components. Results: A bifactor S-1 model better represent the 14 CIS-R indicators, composed by an internalizing factor corresponding to depressive symptoms, anxiety, worry and the shared variance of all remaining CIS-R indicators, and also by residual variance explained by a somatic (e.g., fatigue and pain) and fear (e.g., panic and phobias) specific factors. Internalizing spectrum (13 = 0.116; p < 0.001) and the fear specific factor (13 = 0.060; p = 0.008) were associated with MetS after adjusting for confounders, whereas somatic specific factor was unlikely to be associated with MetS (13 = 0.002; p = 0.934). Conclusions: Anxiety and depression indicators were associated with MetS via a shared internalizing factor and also by a residual fear factor, but not by somatic residual factor. This finding has potential implications about shared biological and behavioral mechanisms that may link emotional conditions with MetS in adults.
C1 [Hoffmann, Mauricio Scopel] Univ Fed Santa Maria, Dept Neuropsiquiatria, Ave Roraima 1000, BR-97105900 Santa Maria, RS, Brazil.
   [Hoffmann, Mauricio Scopel; Salum, Giovanni Abrahao] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Sect Negat Affect & Social Proc, Ramiro Barcelos 2350, BR-90035003 Porto Alegre, RS, Brazil.
   [Hoffmann, Mauricio Scopel; Salum, Giovanni Abrahao] Hosp Clin Porto Alegre, Ramiro Barcelos 2350, BR-90035003 Porto Alegre, RS, Brazil.
   [Brunoni, Andre Russowsky; Lotufo, Paulo Andrade; Bensenor, Isabela Martins] Univ Sao Paulo, Hosp Univ, Fac Med, Ctr Pesquisa Clin & Epidemiol, Sao Paulo, Brazil.
   [Brunoni, Andre Russowsky; Lotufo, Paulo Andrade; Bensenor, Isabela Martins] Univ Sao Paulo, Lab Neurosci LIM 27, Inst Nacl Biomarcadores Neuropsiquiatria Inb, Dept & Inst Psychiat,Fac Med, R Dr Ovidio Pires de Campos 785,2o Andar, BR-05403000 Sao Paulo, Brazil.
   [Stringaris, Argyris] NIMH, Emot & Dev Branch, NIH, Bethesda, MD 20892 USA.
   [Viana, Maria Carmen] Univ Fed Espirito Santo, Dept Social Med, Postgrad Program Publ Hlth, Av Maruipe 1468, BR-29047105 Vitoria, ES, Brazil.
   [Salum, Giovanni Abrahao] Univ Fed Rio Grande do Sul, Dept Psychiat, Rua Ramiro Barcelos 2350, BR-90035003 Porto Alegre, RS, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal do Rio
   Grande do Sul; Hospital de Clinicas de Porto Alegre; Hospital de
   Clinicas de Porto Alegre; Universidade de Sao Paulo; Universidade de Sao
   Paulo; National Institutes of Health (NIH) - USA; NIH National Institute
   of Mental Health (NIMH); Universidade Federal do Espirito Santo;
   Universidade Federal do Rio Grande do Sul
RP Hoffmann, MS (corresponding author), Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Ramiro Barcelos 2350, BR-90035 Porto Alegre, RS, Brazil.
EM mauricio.hoffmann@ufsm.br; brunowsky@gmail.com;
   argyris.stringaris@nih.gov; mcviana6@gmail.com; paulo.lotufo@gmail.com;
   isabensenor@gmail.com; gsalumjr@gmail.com
RI Salum, Giovanni/A-7849-2010; Hoffmann, Mauricio/AAM-9899-2020; Bensenor,
   Isabela/L-3306-2017; Lotufo, Paulo/A-9843-2008; Stringaris,
   Argyris/N-1135-2017; Russowsky Brunoni, Andre/H-8394-2012
OI Scopel Hoffmann, Mauricio/0000-0003-4232-3169; Stringaris,
   Argyris/0000-0002-6264-8377; Russowsky Brunoni,
   Andre/0000-0002-6310-3571; Bensenor, Isabela/0000-0002-6723-5678
CR ACHENBAC.TM, 1966, PSYCHOL MONOGR, V80, P1, DOI 10.1037/h0093906
   American Psychiatric Association, 2013, Diagnostic and Statistical Manual of Mental Disorders: DSM-IV, DOI [DOI 10.1176/APPI.BOOKS.9780890425596, 10.1176/appi.books.9780890425596]
   Aquino EML, 2012, AM J EPIDEMIOL, V175, P315, DOI 10.1093/aje/kwr294
   da Silva CTB, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.118.011011
   Besteher B, 2020, NEUROPSYCHOBIOLOGY, V79, P270, DOI 10.1159/000501024
   Blanquet M, 2019, DIABETES METAB SYND, V13, P1805, DOI 10.1016/j.dsx.2019.04.003
   Bornovalova MA, 2020, BIOL PSYCHIAT, V88, P18, DOI 10.1016/j.biopsych.2020.01.013
   BOTEGA NJ, 1995, SOC PSYCH PSYCH EPID, V30, P127, DOI 10.1007/BF00802041
   Butnoriene J, 2014, PSYCHONEUROENDOCRINO, V40, P269, DOI 10.1016/j.psyneuen.2013.11.002
   Caspi A, 2018, AM J PSYCHIAT, V175, P831, DOI 10.1176/appi.ajp.2018.17121383
   Charpentier CJ, 2017, BIOL PSYCHIAT, V81, P1014, DOI 10.1016/j.biopsych.2016.12.010
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Das-Munshi J, 2014, INT J METH PSYCH RES, V23, P229, DOI 10.1002/mpr.1428
   Dixon JB, 2003, ARCH INTERN MED, V163, P2058, DOI 10.1001/archinte.163.17.2058
   Eid M, 2017, PSYCHOL METHODS, V22, P541, DOI 10.1037/met0000083
   Fabricatore AN, 2011, INT J OBESITY, V35, P1363, DOI 10.1038/ijo.2011.2
   Faisal-Cury A, 2009, ARCH WOMEN MENT HLTH, V12, P335, DOI 10.1007/s00737-009-0081-6
   Firth J, 2020, WORLD PSYCHIATRY, V19, P360, DOI 10.1002/wps.20773
   Fried E. I., 2018, USING NETWORK ANAL E, P2, DOI [10.31234/osf.io/84ske, DOI 10.31234/OSF.IO/84SKE]
   Haffner SM, 2006, AM J CARDIOL, V97, p3A, DOI 10.1016/j.amjcard.2005.11.010
   Hasler G, 2012, NEUROSCI BIOBEHAV R, V36, P64, DOI 10.1016/j.neubiorev.2011.04.011
   Heinrich M., 2020, MEANING GEN FACTOR P, DOI [10.31234/osf.io/syj9k, DOI 10.31234/OSF.IO/SYJ9K]
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Hildrum B, 2009, ACTA PSYCHIAT SCAND, V120, P14, DOI 10.1111/j.1600-0447.2008.01315.x
   Hiles SA, 2016, DEPRESS ANXIETY, V33, P754, DOI 10.1002/da.22512
   Hu LT, 1999, STRUCT EQU MODELING, V6, P1, DOI 10.1080/10705519909540118
   International Committee of Medical Journal Editors (ICMJE), 2019, REC COND REP ED PUBL
   Kahl KG, 2015, BRAIN BEHAV, V5, DOI 10.1002/brb3.306
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   Kappelmann N, 2021, JAMA PSYCHIAT, V78, P161, DOI 10.1001/jamapsychiatry.2020.3436
   Kline R.B., 2015, Principles and Practice of Structural Equation Modeling, DOI [10.15353/cgjsc.v1i1.3787, DOI 10.15353/CGJSC.V1I1.3787]
   Koch T, 2018, PSYCHOL METHODS, V23, P505, DOI 10.1037/met0000146
   Kotov R, 2021, ANNU REV CLIN PSYCHO, V17, P83, DOI 10.1146/annurev-clinpsy-081219-093304
   Lahey BB, 2021, WORLD PSYCHIATRY, V20, P57, DOI 10.1002/wps.20824
   Lahey BB, 2012, J ABNORM PSYCHOL, V121, P971, DOI 10.1037/a0028355
   Lamers F, 2011, J CLIN PSYCHIAT, V72, P341, DOI 10.4088/JCP.10m06176blu
   LEWIS G, 1992, PSYCHOL MED, V22, P465, DOI 10.1017/S0033291700030415
   Li Q, 2020, NEUROPSYCHOPHARMACOL, V45, P703, DOI 10.1038/s41386-019-0563-9
   Licht CMM, 2010, J CLIN ENDOCR METAB, V95, P2458, DOI 10.1210/jc.2009-2801
   Lorant V, 2003, AM J EPIDEMIOL, V157, P98, DOI 10.1093/aje/kwf182
   Luppino FS, 2011, PSYCHOSOM MED, V73, P257, DOI 10.1097/PSY.0b013e31820a59c0
   Marazziti D, 2014, CNS SPECTRUMS, V19, P293, DOI 10.1017/S1092852913000667
   McBride O, 2013, J AFFECT DISORDERS, V148, P310, DOI 10.1016/j.jad.2012.12.016
   McLaughlin KA, 2011, BEHAV RES THER, V49, P186, DOI 10.1016/j.brat.2010.12.006
   Momen NC, 2020, NEW ENGL J MED, V382, P1721, DOI 10.1056/NEJMoa1915784
   Morys F., 2020, OBESITY IMPAIRS COGN, V6, DOI DOI 10.1101/2020.06.26.174086
   Nousen EK, 2013, NEUROENDOCRINOLOGY, V98, P254, DOI 10.1159/000355632
   Nunes M.A., 2012, CLIN BIOMEDICAL RES, V31
   Organization W.H., 2017, Depression and other common mental disorders: Global health estimates
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   RAGLAND DR, 1992, EPIDEMIOLOGY, V3, P434, DOI 10.1097/00001648-199209000-00009
   Ringwald W.R., 2021, METAANALYSIS STRUCTU, DOI [10.31234/osf.io/9xf8z, DOI 10.31234/OSF.IO/9XF8Z]
   Rodriguez A, 2016, J PERS ASSESS, V98, P223, DOI 10.1080/00223891.2015.1089249
   Rosseel Y., 2018, lavaan: Latent Variable Analysis (Version 0.6-2)
   Schmidt MI, 2015, INT J EPIDEMIOL, V44, P68, DOI 10.1093/ije/dyu027
   Sharp C, 2012, BIOL PSYCHIAT, V72, P87, DOI 10.1016/j.biopsych.2012.02.029
   Singleton N, 2003, INT REV PSYCHIATR, V15, P65, DOI 10.1080/0954026021000045967
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Smith GT, 2020, ANNU REV CLIN PSYCHO, V16, P75, DOI 10.1146/annurev-clinpsy-071119-115848
   Takeuchi T, 2009, DIABETES-METAB RES, V25, P762, DOI 10.1002/dmrr.1041
   Tang F, 2017, PSYCHONEUROENDOCRINO, V77, P112, DOI 10.1016/j.psyneuen.2016.11.025
   Van Bork R, 2017, DISPUTATIO, V9, P581, DOI 10.1515/disp-2017-0019
   Whiteford HA, 2013, LANCET, V382, P1575, DOI 10.1016/S0140-6736(13)61611-6
   Xia LS, 2017, FRONT BEHAV NEUROSCI, V11, DOI 10.3389/fnbeh.2017.00005
   Yamaoka K, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-138
NR 65
TC 10
Z9 10
U1 5
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD MAY
PY 2021
VL 137
BP 117
EP 125
DI 10.1016/j.jpsychires.2021.02.052
EA MAR 2021
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA RT4MC
UT WOS:000644433900017
PM 33677215
DA 2025-06-11
ER

PT J
AU Rampersaud, R
   Wu, GWY
   Reus, VI
   Lin, J
   Blackburn, EH
   Epel, ES
   Hough, CM
   Mellon, SH
   Wolkowitz, OM
AF Rampersaud, Ryan
   Wu, Gwyneth W. Y.
   Reus, Victor I.
   Lin, Jue
   Blackburn, Elizabeth H.
   Epel, Elissa S.
   Hough, Christina M.
   Mellon, Synthia H.
   Wolkowitz, Owen M.
TI Shorter telomere length predicts poor antidepressant response and poorer
   cardiometabolic indices in major depression
SO SCIENTIFIC REPORTS
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; ALLOSTATIC LOAD;
   PSYCHIATRIC-DISORDERS; HIPPOCAMPAL VOLUME; FOLLOW-UP; LIFE-SPAN; HUMAN
   T; ASSOCIATION; ANXIETY
AB Telomere length (TL) is a marker of biological aging, and shorter telomeres have been associated with several medical and psychiatric disorders, including cardiometabolic dysregulation and Major Depressive Disorder (MDD). In addition, studies have shown shorter TL to be associated with poorer response to certain psychotropic medications, and our previous work suggested shorter TL and higher telomerase activity (TA) predicts poorer response to Selective Serotonin Reuptake Inhibitor (SSRI) treatment. Using a new group of unmedicated medically healthy individuals with MDD (n = 48), we sought to replicate our prior findings demonstrating that peripheral blood mononuclear cell (PBMC) TL and TA predict response to SSRI treatment and to identify associations between TL and TA with biological stress mediators and cardiometabolic risk indices. Our results demonstrate that longer pre-treatment TL was associated with better response to SSRI treatment (& beta; = .407 p = .007). Additionally, we observed that TL had a negative relationship with allostatic load (& beta; = - .320 p = .017) and a cardiometabolic risk score (& beta; = - .300 p = .025). Our results suggest that PBMC TL reflects, in part, the cumulative effects of physiological stress and cardiovascular risk in MDD and may be a biomarker for predicting SSRI response.
C1 [Rampersaud, Ryan; Wu, Gwyneth W. Y.; Reus, Victor I.; Epel, Elissa S.; Hough, Christina M.; Wolkowitz, Owen M.] Univ Calif San Francisco UCSF, Weill Inst Neurosci, Sch Med, San Francisco, CA 94158 USA.
   [Rampersaud, Ryan; Wu, Gwyneth W. Y.; Reus, Victor I.; Epel, Elissa S.; Hough, Christina M.; Wolkowitz, Owen M.] Univ Calif San Francisco UCSF, Dept Psychiat & Behav Sci, Sch Med, San Francisco, CA 94143 USA.
   [Lin, Jue; Blackburn, Elizabeth H.] Univ Calif San Francisco UCSF, Dept Biochem & Biophys, Sch Med, San Francisco, CA USA.
   [Mellon, Synthia H.] UCSF, Dept OB GYN & Reprod Sci, Sch Med, San Francisco, CA USA.
   [Hough, Christina M.] Univ Calif Los Angeles UCLA, Dept Psychol, Los Angeles, CA USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   University of California System; University of California Los Angeles
RP Rampersaud, R (corresponding author), Univ Calif San Francisco UCSF, Weill Inst Neurosci, Sch Med, San Francisco, CA 94158 USA.; Rampersaud, R (corresponding author), Univ Calif San Francisco UCSF, Dept Psychiat & Behav Sci, Sch Med, San Francisco, CA 94143 USA.
EM ryan.rampersaud@ucsf.edu
RI Epel, Elissa/ABI-6703-2022; Wolkowitz, Owen/J-6649-2013; reus,
   victor/I-7923-2015
FU Institute of Mental Health (NIMH) [R01-MH083784]; Tinberg family; UCSF
   Academic Senate; UCSF Research Evaluation and Allocation Committee;
   National Institutes of Health/National Center for Research Resources;
   National Center for Advancing Translational Sciences, NIH through
   UCSF-CTSI [UL1 RR024131, TL-1 TR001871];  [NCT00285935]; National Center
   for Advancing Translational Sciences [TL1TR001871] Funding Source: NIH
   RePORTER
FX The authors acknowledge the assistance of Phuong Hoang, Stacy Ann
   Miller, the UCSF CTSI Clinical Research Center staff, the PNE Lab
   research assistants, volunteers and research participants. This study
   was funded by grants from the Institute of Mental Health (NIMH)
   (R01-MH083784), the Tinberg family, UCSF Academic Senate, and UCSF
   Research Evaluation and Allocation Committee. This project was also
   supported by National Institutes of Health/National Center for Research
   Resources and the National Center for Advancing Translational Sciences,
   NIH, through UCSF-CTSI Grant UL1 RR024131 and TL-1 TR001871. Clinical
   Trial Registry Number (NCT00285935). None of the funding agencies had a
   role in the design/conduct of the study; collection, management,
   analysis, and interpretation of the data; and preparation, review, or
   approval of the manuscript.
CR Aas M, 2019, TRANSL PSYCHIAT, V9, DOI 10.1038/s41398-019-0432-7
   Ahrens KA, 2016, PAEDIATR PERINAT EP, V30, P325, DOI 10.1111/ppe.12277
   Arteaga-Henríquez G, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00458
   Barnes RP, 2019, MECH AGEING DEV, V177, P37, DOI 10.1016/j.mad.2018.03.013
   Beach SRH, 2021, DEV PSYCHOPATHOL, V33, P803, DOI 10.1017/S0954579420000061
   Bersani FS, 2015, DRUG DISCOV TODAY, V20, P1305, DOI 10.1016/j.drudis.2015.06.016
   Blackburn EH, 2005, FEBS LETT, V579, P859, DOI 10.1016/j.febslet.2004.11.036
   Blasco MA, 1997, CELL, V91, P25, DOI 10.1016/S0092-8674(01)80006-4
   Brouilette S, 2003, ARTERIOSCL THROM VAS, V23, P842, DOI 10.1161/01.ATV.0000067426.96344.32
   Brown L, 2017, J AGING HEALTH, V29, P1350, DOI 10.1177/0898264316661390
   Brydon L, 2012, BIOL PSYCHIAT, V71, P767, DOI 10.1016/j.biopsych.2011.08.020
   Bürgin D, 2019, FRONT NEUROSCI-SWITZ, V13, DOI 10.3389/fnins.2019.00490
   Buxton JL, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0099133
   Chen SH, 2014, J AFFECT DISORDERS, V169, P86, DOI 10.1016/j.jad.2014.07.035
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Colle R., 2016, WORLD J BIOL PSYCHIA, V19, P1
   Coluzzi E, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8010019
   D'Mello MJJ, 2015, CIRC-CARDIOVASC GENE, V8, P82, DOI 10.1161/CIRCGENETICS.113.000485
   Damjanovic AK, 2007, J IMMUNOL, V179, P4249, DOI 10.4049/jimmunol.179.6.4249
   Darrow SM, 2016, PSYCHOSOM MED, V78, P776, DOI 10.1097/PSY.0000000000000356
   Ellehoj H, 2016, CARDIOLOGY, V133, P173, DOI 10.1159/000441819
   Epel ES, 2009, AGING-US, V1, P81
   Epel ES, 2004, P NATL ACAD SCI USA, V101, P17312, DOI 10.1073/pnas.0407162101
   Evans DL, 2005, BIOL PSYCHIAT, V58, P175, DOI 10.1016/j.biopsych.2005.05.001
   Farzaneh-Far R, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008612
   First M. B., 1997, Structured Clinical Interview for DSM-IV Axis I Disorders, Research Version, Patient Edition
   Fitzpatrick AL, 2007, AM J EPIDEMIOL, V165, P14, DOI [10.1093/aje/kw346, 10.1093/aje/kwj346]
   Fuster JJ, 2007, J HYPERTENS, V25, P2185, DOI 10.1097/HJH.0b013e3282ef6196
   Gampawar P, 2022, AGEING RES REV, V80, DOI 10.1016/j.arr.2022.101679
   Gardner M, 2014, EXP GERONTOL, V51, P15, DOI 10.1016/j.exger.2013.12.004
   Georgin-Lavialle S, 2010, AUTOIMMUN REV, V9, P646, DOI 10.1016/j.autrev.2010.04.004
   Groer M, 2020, BIOL RES NURS, V22, P256, DOI 10.1177/1099800419890424
   Guerrero-Romero F, 2010, J CLIN ENDOCR METAB, V95, P3347, DOI 10.1210/jc.2010-0288
   Hamad R, 2016, EBIOMEDICINE, V11, P296, DOI 10.1016/j.ebiom.2016.08.015
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Han LKM, 2018, AM J PSYCHIAT, V175, P774, DOI 10.1176/appi.ajp.2018.17060595
   Haroon E, 2018, PSYCHONEUROENDOCRINO, V95, P43, DOI 10.1016/j.psyneuen.2018.05.026
   Harshfield EL., 2020, J AMER MED ASSOC, V324, P2396, DOI DOI 10.1001/jama.2020.23068
   Hartmann N, 2010, DEPRESS ANXIETY, V27, P1111, DOI 10.1002/da.20749
   Hasin DS, 2018, JAMA PSYCHIAT, V75, P336, DOI 10.1001/jamapsychiatry.2017.4602
   Haycock PC, 2014, BMJ-BRIT MED J, V349, DOI 10.1136/bmj.g4227
   Herrera E, 1999, EMBO J, V18, P2950, DOI 10.1093/emboj/18.11.2950
   Hoen PW, 2013, PSYCHOL MED, V43, P689, DOI 10.1017/S0033291712001766
   Honig LS, 2012, ARCH NEUROL-CHICAGO, V69, P1332, DOI 10.1001/archneurol.2012.1541
   Hough CM, 2021, PSYCHOL MED, V51, P2117, DOI 10.1017/S0033291720000896
   Hough CM, 2017, PSYCHONEUROENDOCRINO, V77, P122, DOI 10.1016/j.psyneuen.2016.11.035
   Hough Christina M, 2016, Mol Neuropsychiatry, V2, P88
   Hu LH, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.844073
   Huang YC, 2022, WORLD J BIOL PSYCHIA, V23, P483, DOI 10.1080/15622975.2021.2013091
   Huang YQ, 2020, ANN TRANSL MED, V8, DOI 10.21037/atm.2020.03.205
   Iwama H, 1998, HUM GENET, V102, P397, DOI 10.1007/s004390050711
   Jacobs EG, 2014, JAMA NEUROL, V71, P921, DOI 10.1001/jamaneurol.2014.870
   Jeanclos E, 2000, HYPERTENSION, V36, P195, DOI 10.1161/01.HYP.36.2.195
   Jin X, 2018, MEDICINE, V97, DOI [10.1097/MD.0000000000012489, 10.1097/md.0000000000012489]
   Vasques ACJ, 2011, DIABETES RES CLIN PR, V93, pE98, DOI 10.1016/j.diabres.2011.05.030
   Jurk D, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms5172
   Katerji M, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/1279250
   Kim NW, 1997, NUCLEIC ACIDS RES, V25, P2595, DOI 10.1093/nar/25.13.2595
   Kroenke CH, 2012, ATHEROSCLEROSIS, V220, P506, DOI 10.1016/j.atherosclerosis.2011.10.041
   Lee M, 2011, AM J HUM BIOL, V23, P100, DOI 10.1002/ajhb.21109
   Li ZC, 2015, SCI REP-UK, V5, DOI 10.1038/srep18553
   Lin J, 2022, AGEING RES REV, V73, DOI 10.1016/j.arr.2021.101507
   Lin J, 2011, BRAIN RES, V1379, P224, DOI 10.1016/j.brainres.2010.10.033
   Lin J, 2010, J IMMUNOL METHODS, V352, P71, DOI 10.1016/j.jim.2009.09.012
   Lindqvist D, 2017, PSYCHONEUROENDOCRINO, V76, P197, DOI 10.1016/j.psyneuen.2016.11.031
   Lindqvist D, 2015, NEUROSCI BIOBEHAV R, V55, P333, DOI 10.1016/j.neubiorev.2015.05.007
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Malouff JM, 2017, ANXIETY STRESS COPIN, V30, P264, DOI 10.1080/10615806.2016.1261286
   Manoliu A, 2018, J AFFECT DISORDERS, V225, P630, DOI 10.1016/j.jad.2017.08.022
   Martinsson L, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.37
   Mazidi M, 2018, ANGIOLOGY, V69, P164, DOI 10.1177/0003319717712860
   Menke A, 2015, BMC ENDOCR DISORD, V15, DOI 10.1186/s12902-015-0050-1
   Minamino Tohru, 2003, J Cardiol, V41, P39
   Mwasongwe S, 2017, ATHEROSCLEROSIS, V266, P41, DOI 10.1016/j.atherosclerosis.2017.09.016
   O'Donovan A, 2011, BIOL PSYCHIAT, V70, P465, DOI 10.1016/j.biopsych.2011.01.035
   O'Donovan A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019687
   Ornish D, 2013, LANCET ONCOL, V14, P1112, DOI 10.1016/S1470-2045(13)70366-8
   Pisanu C, 2020, DRUG DEVELOP RES, V81, P268, DOI 10.1002/ddr.21612
   POST RM, 1988, AM J PSYCHIAT, V145, P844
   Protsenko E, 2021, TRANSL PSYCHIAT, V11, DOI 10.1038/s41398-021-01302-0
   PRYOR WA, 1986, ANNU REV PHYSIOL, V48, P657, DOI 10.1146/annurev.ph.48.030186.003301
   Rampazzo E, 2012, HAEMATOL-HEMATOL J, V97, P56, DOI 10.3324/haematol.2011.049874
   Rasgon N, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2015.187
   Rehkopf DH, 2016, PLOS MED, V13, DOI 10.1371/journal.pmed.1002188
   Révész D, 2016, PSYCHOL MED, V46, P2337, DOI 10.1017/S0033291716000891
   Révész D, 2014, NEUROBIOL AGING, V35, P1422, DOI 10.1016/j.neurobiolaging.2013.12.027
   Ridout KK, 2018, BIOESSAYS, V40, DOI 10.1002/bies.201800077
   Ridout KK, 2016, J AFFECT DISORDERS, V191, P237, DOI 10.1016/j.jad.2015.11.052
   Röth A, 2003, BLOOD, V102, P849, DOI 10.1182/blood-2002-07-2015
   Roux AVD, 2009, AGING CELL, V8, P251, DOI 10.1111/j.1474-9726.2009.00470.x
   Salpea KD, 2010, ATHEROSCLEROSIS, V209, P42, DOI 10.1016/j.atherosclerosis.2009.09.070
   Santarelli L, 2003, SCIENCE, V301, P805, DOI 10.1126/science.1083328
   Schaakxs R, 2015, AM J GERIAT PSYCHIAT, V23, P423, DOI 10.1016/j.jagp.2014.06.003
   Seeman TE, 2001, P NATL ACAD SCI USA, V98, P4770, DOI 10.1073/pnas.081072698
   Shalev C, 2013, PSYCHONEUROENDOCRINO, V38, P1835, DOI 10.1016/j.psyneuen.2013.03.010
   Shalev I, 2012, BIOESSAYS, V34, P943, DOI 10.1002/bies.201200084
   Shin D, 2019, J CLIN MED, V8, DOI 10.3390/jcm8050711
   Simental-Mendia Luis E., 2008, Metabolic Syndrome and Related Disorders, V6, P299, DOI 10.1089/met.2008.0034
   Steenkamp LR, 2017, J AFFECT DISORDERS, V219, P193, DOI 10.1016/j.jad.2017.04.042
   Teyssier JR, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0049677
   Tyrka AR, 2010, BIOL PSYCHIAT, V67, P531, DOI 10.1016/j.biopsych.2009.08.014
   Verhoeven JE, 2014, MOL PSYCHIATR, V19, P895, DOI 10.1038/mp.2013.151
   von Zglinicki T, 2002, TRENDS BIOCHEM SCI, V27, P339, DOI 10.1016/S0968-0004(02)02110-2
   VONZGLINICKI T, 1995, EXP CELL RES, V220, P186, DOI 10.1006/excr.1995.1305
   Walia N, 2023, J AFFECT DISORDERS, V320, P268, DOI 10.1016/j.jad.2022.09.138
   Walker ER, 2015, JAMA PSYCHIAT, V72, P334, DOI 10.1001/jamapsychiatry.2014.2502
   Wang Q, 2018, AGEING RES REV, V48, P11, DOI 10.1016/j.arr.2018.09.002
   Wikgren M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034292
   Wikgren M, 2012, BIOL PSYCHIAT, V71, P294, DOI 10.1016/j.biopsych.2011.09.015
   Williams LM, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.61
   Wolkowitz OM, 2012, MOL PSYCHIATR, V17, P164, DOI 10.1038/mp.2010.133
   Wolkowitz OM, 2015, PSYCHIAT RES-NEUROIM, V232, P58, DOI 10.1016/j.pscychresns.2015.01.007
   Wolkowitz Owen M, 2011, Dialogues Clin Neurosci, V13, P25
   Wolkowitz OM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017837
   Wong JYY, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0087348
   Wong LSM, 2009, CARDIOVASC RES, V81, P244, DOI 10.1093/cvr/cvn337
   Yamanishi Y, 1999, INT J MOL MED, V4, P513
   Yeh JK, 2016, GENES-BASEL, V7, DOI 10.3390/genes7090058
   Yu WY, 2008, J PSYCHIATR NEUROSCI, V33, P244
   Zalli A, 2014, P NATL ACAD SCI USA, V111, P4519, DOI 10.1073/pnas.1322145111
   Zhan YQ, 2019, CURR OPIN CARDIOL, V34, DOI 10.1097/HCO.0000000000000613
NR 121
TC 7
Z9 7
U1 0
U2 7
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 23
PY 2023
VL 13
IS 1
AR 10238
DI 10.1038/s41598-023-35912-z
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA K8FQ8
UT WOS:001018745700056
PM 37353495
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pouragha, H
   Alamdari, RJ
   Pouryaghoub, G
   Saraei, M
   Mehrdad, R
AF Pouragha, Hamidreza
   Alamdari, Rita Javadi
   Pouryaghoub, Gholamreza
   Saraei, Maryam
   Mehrdad, Ramin
TI Is Having a Permanent Job a Predictor of Metabolic Syndrome?
SO ENDOCRINOLOGY RESEARCH AND PRACTICE
LA English
DT Article
DE Metabolic syndrome X; Occupational groups; employment status
ID WORK-FAMILY CONFLICT; RISK-FACTORS; CARDIOVASCULAR RISK; ASSOCIATION;
   PREVALENCE; SLEEP; HYPERTENSION; ENVIRONMENT; OVERTIME; STRESS
AB Objective: Many non-occupational and occupational metabolic syndrome risk factors have been identified. In this study, we examined some occupational risk factors of metabolic syndrome.
   Methods: 3537 employees of Tehran University of Medical Sciences, (1388 male and 2139 female) participated in this cross-sectional study. The prevalence of metabolic syndrome was measured using the International Diabetes Federation criteria, and then we evaluated the association between some job variables such as work-family conflict, shift working, occupational groups and employment status, and metabolic syndrome.
   Result: According to the International Diabetes Federation criteria, the prevalence of metabolic syndrome among employees of Tehran University of Medical Sciences was 22.1%, which was 25.3% and 20.0% for men and women, respectively. In the regression model without the presence of metabolic syndrome component, age, occupational groups, and having a permanent job were predictors of metabolic syndrome. In the model with the presence of metabolic syndrome components, in addition to the metabolic syndrome components, gender and having a permanent job were observed as metabolic syndrome predictors. The study found no association between work-family conflict and metabolic syndrome.
   Conclusion: Having a permanent job is introduced as an occupational predictor of metabolic syndrome.
C1 [Pouragha, Hamidreza; Alamdari, Rita Javadi; Pouryaghoub, Gholamreza; Mehrdad, Ramin] Univ Tehran Med Sci, Ctr Res Occupat Dis, Tehran, Iran.
   [Pouragha, Hamidreza] Mehralborz Univ MAU, Dept Environm Engn, Tehran, Iran.
   [Saraei, Maryam] Univ Tehran Med Sci, Dept Occupat Med, Fac Med, Baharlou Hosp, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences
RP Mehrdad, R (corresponding author), Univ Tehran Med Sci, Ctr Res Occupat Dis, Tehran, Iran.
EM mehrdadr@tums.ac.ir
RI pouragha, hamidreza/JVZ-3553-2024; saraei, maryam/AAT-1236-2020
OI Pouragha, Hamidreza/0000-0002-9748-2864
CR Akintunde AA, 2017, DIABETES METAB SYND, V11, pS223, DOI 10.1016/j.dsx.2016.12.035
   Al-Lawati JA, 2003, DIABETES CARE, V26, P1781, DOI 10.2337/diacare.26.6.1781
   Behboudi-Gandevani S, 2016, EUR J OBSTET GYN R B, V205, P110, DOI 10.1016/j.ejogrb.2016.08.011
   Bergmann N, 2014, ENDOCR CONNECT, V3, pR55, DOI 10.1530/EC-14-0031
   Berkman LF, 2015, J OCCUP HEALTH PSYCH, V20, P420, DOI 10.1037/a0039143
   Bonora E, 2018, ENDOCRINOL SER, P1, DOI 10.1007/978-3-319-44433-8
   Bulka CM, 2017, J OCCUP ENVIRON MED, V59, P1047, DOI 10.1097/JOM.0000000000001115
   Chen PE, 2019, J MENS HEALTH, V15, pE1, DOI 10.22374/jomh.v15i2.106
   Chen WL, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0202977
   Cheserek MJ, 2018, AFR HEALTH SCI, V18, P842, DOI 10.4314/ahs.v18i4.2
   Chico-Barba G, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16111993
   Cho DY, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15091798
   Cho JJ, 2006, KOREAN J OCCUP ENV M, V18, P209
   Dalvand S, 2017, IRAN J PUBLIC HEALTH, V46, P456
   das Merces MC, 2019, ACTA PAUL ENFERM, V32, P470, DOI 10.1590/1982-0194201900064
   das Merces MC, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16152686
   das Merces MC, 2016, PSICOL-REFLEX CRIT, V29, DOI 10.1186/s41155-016-0051-7
   Davila EP, 2010, DIABETES CARE, V33, P2390, DOI 10.2337/dc10-0681
   Edwards EM, 2012, J OCCUP ENVIRON MED, V54, P1447, DOI 10.1097/JOM.0b013e3182783f27
   Fernandez-Montero A, 2019, J OCCUP ENVIRON MED, V61, P729, DOI 10.1097/JOM.0000000000001645
   Ferreira B., 2020, Translational Metabolic Syndrome Research, V3, P9, DOI DOI 10.1016/J.TMSR.2020.03.002
   Grundy SM, 2016, TRENDS CARDIOVAS MED, V26, P364, DOI 10.1016/j.tcm.2015.10.004
   Huang JH, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-13872-5
   강소희, 2016, [Korean Journal of Adult Nursing, 성인간호학회지], V28, P180, DOI 10.7475/kjan.2016.28.2.180
   Jeong HS, 2018, INT J OCCUP ENV MED, V9, P176, DOI 10.15171/ijoem.2018.1346
   Kivimäki M, 2015, CURR CARDIOL REP, V17, DOI 10.1007/s11886-015-0630-8
   Lemke MK, 2017, OCCUP MED-OXFORD, V67, P274, DOI 10.1093/occmed/kqx029
   Li JB, 2010, J INT MED RES, V38, P1142, DOI 10.1177/147323001003800343
   Lidén E, 2020, SCAND J WORK ENV HEA, V46, P402, DOI 10.5271/sjweh.3881
   Liu Y, 2002, OCCUP ENVIRON MED, V59, P447, DOI 10.1136/oem.59.7.447
   Magnavita N., 2017, Eur. J. Public Health, V27, DOI .1093/eurpub/ckx187.088
   Marotta T, 2010, OBESITY, V18, P1608, DOI 10.1038/oby.2009.446
   MATTHEW DAT, 2018, Asian J Med Health, V12, P1, DOI 10.9734/AJMAH/2018/43851
   Mehrdad R, 2018, INT J OCCUP ENV MED, V9, P45, DOI 10.15171/ijoem.2018.1197
   Mozafari M, 2016, INT J OCCUP ENV MED, V7, P164, DOI 10.15171/ijoem.2016.748
   Nakanishi N, 2001, J EPIDEMIOL COMMUN H, V55, P316, DOI 10.1136/jech.55.5.316
   Nedjat S, 2020, BMC PUBLIC HEALTH, V20, DOI 10.1186/s12889-020-09798-9
   Niazi E, 2019, DIABETES METAB SYND, V13, P338, DOI 10.1016/j.dsx.2018.10.013
   Ortiz MS, 2018, REV MED CHILE, V146, P1278, DOI 10.4067/S0034-98872018001101278
   Pandalai SP, 2013, SCAND J WORK ENV HEA, V39, P221, DOI 10.5271/sjweh.3363
   Park JS, 2001, IND HEALTH, V39, P244, DOI 10.2486/indhealth.39.244
   Pedersen JM, 2016, INT J CARDIOL, V215, P41, DOI 10.1016/j.ijcard.2016.04.076
   Penedo FJ, 2015, ANN BEHAV MED, V49, P793, DOI 10.1007/s12160-015-9713-4
   Pietroiusti A, 2010, OCCUP ENVIRON MED, V67, P54, DOI 10.1136/oem.2009.046797
   Ryu H, 2017, ARCH ENVIRON OCCUP H, V72, P249, DOI 10.1080/19338244.2016.1200004
   Santos AE, 2018, AM J IND MED, V61, P911, DOI 10.1002/ajim.22910
   Sisson SB, 2009, METAB SYNDR RELAT D, V7, P529, DOI 10.1089/met.2009.0023
   Strauss M, 2016, DIABETOL METAB SYNDR, V8, DOI 10.1186/s13098-016-0174-0
   Thayyil J, 2012, N AM J MED SCI, V4, P630, DOI 10.4103/1947-2714.104313
   Versey HS, 2020, J HEALTH PSYCHOL, V25, P1771, DOI 10.1177/1359105318764014
   Watanabe K, 2018, OBES REV, V19, P1557, DOI 10.1111/obr.12725
   Yang H, 2006, HYPERTENSION, V48, P744, DOI 10.1161/01.HYP.0000238327.41911.52
NR 52
TC 0
Z9 0
U1 0
U2 1
PU AVES
PI SISLI
PA BUYUKDERE CAD 105-9, MECIDIYEKOY, SISLI, ISTANBUL 34394, Turkiye
EI 2822-6135
J9 ENDOCRINOL RES PRACT
JI Endocrinol. Res. Pract.
PD APR
PY 2023
VL 27
IS 2
BP 65
EP 70
DI 10.5152/erp.2023.225079
PG 6
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA Z2FV3
UT WOS:001110296900006
OA gold
DA 2025-06-11
ER

PT J
AU Mazgelyte, E
   Mazeikiene, A
   Burokiene, N
   Matuzeviciene, R
   Linkeviciute, A
   Kucinskiene, ZA
   Karciauskaite, D
AF Mazgelyte, Egle
   Mazeikiene, Asta
   Burokiene, Neringa
   Matuzeviciene, Reda
   Linkeviciute, Ausra
   Kucinskiene, Zita Ausrele
   Karciauskaite, Dovile
TI Association between hair cortisol concentration and metabolic syndrome
SO OPEN MEDICINE
LA English
DT Article
DE cortisol; metabolic syndrome; psychosocial stress
ID PITUITARY-ADRENAL AXIS; SALIVARY CORTISOL; PERCEIVED STRESS;
   PATHOGENESIS; MEN; DISORDER; MARKER
AB Metabolic syndrome (MetS) is a highly prevalent disorder defined as a cluster of cardiometabolic risk factors including obesity, hyperglycemia, hypertension, and dyslipidemia. It is believed that excessive cortisol secretion due to psychosocial stress-induced hypothalamic-pituitary-adrenal axis activation might be involved in the pathogenesis of MetS. We sought to explore the association between MetS and psychosocial risk factors, as well as cortisol concentration measured in different biological specimens including saliva, blood serum, and hair samples. The study was conducted on a sample of 163 young and middle-aged men who were divided into groups according to the presence of MetS. Hair cortisol concentration (HCC) was determined using high performance liquid chromatography with UV detection, while blood serum and salivary cortisol levels were measured by enzyme-linked immunoassay. Lipid metabolism biomarkers were determined using routine laboratory methods. Anthropometric and lifestyle characteristics, as well as self-reported psychosocial indicators, were also examined. Significantly higher HCC and lower social support level among participants with MetS compared with individuals without MetS were found. However, no significant differences in blood serum and salivary cortisol levels were observed between men with and without MetS. In conclusion, chronically elevated cortisol concentration might be a potential contributing factor to the development of MetS.
C1 [Mazgelyte, Egle; Mazeikiene, Asta; Matuzeviciene, Reda; Linkeviciute, Ausra; Kucinskiene, Zita Ausrele; Karciauskaite, Dovile] Vilnius Univ, Dept Physiol Biochem Microbiol & Lab Med, Inst Biomed Sci, Fac Med, Vilnius, Lithuania.
   [Burokiene, Neringa] Vilnius Univ, Inst Clin Med, Clin Internal Dis Family Med & Oncol, Vilnius, Lithuania.
C3 Vilnius University; Vilnius University
RP Mazgelyte, E (corresponding author), Vilnius Univ, Dept Physiol Biochem Microbiol & Lab Med, Inst Biomed Sci, Fac Med, Vilnius, Lithuania.
EM egle.mazgelyte@mf.vu.lt
RI Karciauskaite, Dovile/NGR-6322-2025; Matuzeviciene, Reda/GSI-5971-2022;
   Mazeikiene, Asta/NGQ-8907-2025; Mazgelyte, Egle/GXM-8634-2022
OI Linkeviciute-Dumce, Ausra/0000-0001-8682-4251; Mazeikiene,
   Asta/0000-0002-3308-068X; Mazgelyte, Egle/0000-0002-1033-0607
FU Research Council of Lithuania [MIP-050/2015]
FX This work was supported by the Research Council of Lithuania (Grant No.
   MIP-050/2015).
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Almadi T, 2013, PSYCHOPHYSIOLOGY, V50, P821, DOI 10.1111/psyp.12069
   Andreassi MG, 2009, MUTAT RES-FUND MOL M, V667, P35, DOI 10.1016/j.mrfmmm.2008.10.018
   Arnaldi G, 2010, NEUROENDOCRINOLOGY, V92, P86, DOI 10.1159/000314213
   Baid S, 2004, CURR HYPERTENS REP, V6, P493, DOI 10.1007/s11906-004-0046-0
   Branth S, 2007, NUTR METAB CARDIOVAS, V17, P427, DOI 10.1016/j.numecd.2006.03.001
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   Clow A, 2020, INT REV NEUROBIOL, V150, P1, DOI 10.1016/bs.irn.2019.12.003
   Constantinopoulos P, 2015, EUR J ENDOCRINOL, V172, DOI 10.1530/EJE-14-0626
   De Palo EF, 2009, CLIN CHIM ACTA, V405, P60, DOI 10.1016/j.cca.2009.04.006
   Eftekhari S, 2021, J DIABETES METAB DIS, V20, P321, DOI 10.1007/s40200-021-00748-9
   Ortiz-Matamoros MF, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0132693
   Garcez A, 2018, PSYCHONEUROENDOCRINO, V95, P50, DOI 10.1016/j.psyneuen.2018.05.023
   Garcez A, 2017, HORM METAB RES, V49, P510, DOI 10.1055/s-0043-101822
   Greff MJE, 2019, CLIN BIOCHEM, V63, P1, DOI 10.1016/j.clinbiochem.2018.09.010
   Han TS, 2016, JRSM CARDIOVASC DIS, V5, DOI 10.1177/2048004016633371
   Hwang WJ, 2014, JPN J NURS SCI, V11, P23, DOI 10.1111/j.1742-7924.2012.00226.x
   Jeong IK, 2012, DIABETES METAB J, V36, P207, DOI 10.4093/dmj.2012.36.3.207
   Khani S, 2001, CLIN SCI, V101, P739, DOI [10.1042/CS20010180, 10.1042/cs1010739]
   Kristenson M, 1998, PSYCHOSOM MED, V60, P277, DOI 10.1097/00006842-199805000-00011
   Kuehl LK, 2015, PSYCHONEUROENDOCRINO, V51, P365, DOI 10.1016/j.psyneuen.2014.09.012
   Lanfear JH, 2020, STEROIDS, V163, DOI 10.1016/j.steroids.2020.108712
   Langerak T, 2015, CLIN ENDOCRINOL, V83, P167, DOI 10.1111/cen.12790
   Lee DY, 2015, BMB REP, V48, P209, DOI 10.5483/BMBRep.2015.48.4.275
   Lehrer HM, 2020, PSYCHONEUROENDOCRINO, V113, DOI 10.1016/j.psyneuen.2019.104510
   Maggio M, 2006, J AM GERIATR SOC, V54, P1832, DOI 10.1111/j.1532-5415.2006.00963.x
   Martinac M, 2017, PSYCHIAT DANUB, V29, P39, DOI 10.24869/psyd.2017.39
   Meyer JS, 2012, ENDOCRINOLOGY, V153, P4120, DOI 10.1210/en.2012-1226
   Nolan Paul B, 2017, Prev Med Rep, V7, P211, DOI 10.1016/j.pmedr.2017.07.004
   Pakalska-Korcala A, 2008, KARDIOL POL, V66, P500
   Park SB, 2011, J KOREAN MED SCI, V26, P914, DOI 10.3346/jkms.2011.26.7.914
   Pedersen JM, 2016, INT J CARDIOL, V215, P41, DOI 10.1016/j.ijcard.2016.04.076
   Raul JS, 2004, CLIN BIOCHEM, V37, P1105, DOI 10.1016/j.clinbiochem.2004.02.010
   REYNOLDS WM, 1981, J CONSULT CLIN PSYCH, V49, P306, DOI 10.1037/0022-006X.49.2.306
   Russell E, 2012, PSYCHONEUROENDOCRINO, V37, P589, DOI 10.1016/j.psyneuen.2011.09.009
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Stalder T, 2013, J CLIN ENDOCR METAB, V98, P2573, DOI 10.1210/jc.2013-1056
   Stalder T, 2012, BRAIN BEHAV IMMUN, V26, P1019, DOI 10.1016/j.bbi.2012.02.002
   Steel JL, 2019, PSYCHO-ONCOLOGY, V28, P1735, DOI 10.1002/pon.5147
   Takahashi A, 2020, J ATHEROSCLER THROMB, V27, P1010, DOI 10.5551/jat.52225
   Tenk J, 2018, PSYCHONEUROENDOCRINO, V95, P63, DOI 10.1016/j.psyneuen.2018.05.014
   Unger T, 2020, J HYPERTENS, V38, P982, DOI [10.1097/HJH.0000000000002453, 10.1161/HYPERTENSIONAHA.120.15026]
   van den Heuvel LL, 2020, STRESS, V23, P577, DOI 10.1080/10253890.2020.1724949
   Vigna L, 2019, EAT WEIGHT DISORD-ST, V24, P73, DOI 10.1007/s40519-018-0536-8
   Wang HH, 2020, PEDIATR GASTROENTERO, V23, P189
   Wester VL., 2017, HYPOTHALAMIC PITUITA, P303
   Wood P, 2009, ANN CLIN BIOCHEM, V46, P183, DOI 10.1258/acb.2008.008208
NR 47
TC 0
Z9 0
U1 0
U2 5
PU DE GRUYTER POLAND SP Z O O
PI WARSAW
PA BOGUMILA ZUGA 32A STR, 01-811 WARSAW, MAZOVIA, POLAND
SN 2391-5463
J9 OPEN MED-WARSAW
JI Open Med.
PD JUN 16
PY 2021
VL 16
IS 1
BP 873
EP 881
DI 10.1515/med-2021-0298
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA TR9VP
UT WOS:000679306500002
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Meister, R
   Princip, M
   Schmid, JP
   Schnyder, U
   Barth, J
   Znoj, H
   Herbert, C
   von Känel, R
AF Meister, Rebecca
   Princip, Mary
   Schmid, Jean-Paul
   Schnyder, Ulrich
   Barth, Juergen
   Znoj, Hansjoerg
   Herbert, Claudia
   von Kaenel, Roland
TI Myocardial Infarction - Stress PRevention INTervention (MI-SPRINT) to
   reduce the incidence of posttraumatic stress after acute myocardial
   infarction through trauma-focused psychological counseling: study
   protocol for a randomized controlled trial
SO TRIALS
LA English
DT Article
DE Anxiety disorder; Biomarkers; Cardiovascular disease; Counseling;
   Myocardial infarction; Posttraumatic stress disorder; Prevention;
   Psychological stress; Psychotherapy; Randomized controlled trial
ID CORONARY-HEART-DISEASE; SELF-REPORT MEASURE; QUALITY-OF-LIFE; DISORDER
   SYMPTOMS; GERMAN VERSION; HEALTH-STATUS; RISK-FACTORS; SCALE; PTSD;
   DISTRESS
AB Background: Posttraumatic Stress Disorder (PTSD) may occur in patients after exposure to a life-threatening illness. About one out of six patients develop clinically relevant levels of PTSD symptoms after acute myocardial infarction (MI). Symptoms of PTSD are associated with impaired quality of life and increase the risk of recurrent cardiovascular events. The main hypothesis of the MI-SPRINT study is that trauma-focused psychological counseling is more effective than non-trauma focused counseling in preventing posttraumatic stress after acute MI.
   Methods/Design: The study is a single-center, randomized controlled psychological trial with two active intervention arms. The sample consists of 426 patients aged 18 years or older who are at 'high risk' to develop clinically relevant posttraumatic stress symptoms. 'High risk' patients are identified with three single-item questions with a numeric rating scale (0 to 10) asking about 'pain during MI', 'fear of dying until admission' and/or 'worrying and feeling helpless when being told about having MI'. Exclusion criteria are emergency heart surgery, severe comorbidities, current severe depression, disorientation, cognitive impairment and suicidal ideation. Patients will be randomly allocated to a single 45-minute counseling session targeting either specific MI-triggered traumatic reactions (that is, the verum intervention) or the general role of psychosocial stress in coronary heart disease (that is, the control intervention). The session will take place in the coronary care unit within 48 hours, by the bedside, after patients have reached stable circulatory conditions. Each patient will additionally receive an illustrated information booklet as study material. Sociodemographic factors, psychosocial and medical data, and cardiometabolic risk factors will be assessed during hospitalization. The primary outcome is the interviewer-rated posttraumatic stress level at three-month follow-up, which is hypothesized to be at least 20% lower in the verum group than in the control group using the t-test. Secondary outcomes are posttraumatic stress levels at 12-month follow-up, and psychosocial functioning and cardiometabolic risk factors at both follow-up assessments.
   Discussion: If the verum intervention proves to be effective, the study will be the first to show that a brief trauma-focused psychological intervention delivered within a somatic health care setting can reduce the incidence of posttraumatic stress in acute MI patients.
C1 [Meister, Rebecca; Princip, Mary; von Kaenel, Roland] Univ Bern, Inselspital, Univ Hosp Bern, Dept Gen Internal Med,Div Psychosomat Med, CH-3010 Bern, Switzerland.
   [Meister, Rebecca; Princip, Mary; von Kaenel, Roland] Univ Bern, Dept Clin Res, Bern, Switzerland.
   [Meister, Rebecca; Princip, Mary; Znoj, Hansjoerg] Univ Bern, Div Clin Psychol & Psychotherapy, Inst Psychol, Bern, Switzerland.
   [Schmid, Jean-Paul; von Kaenel, Roland] Univ Bern, Inselspital, Univ Hosp Bern, Dept Cardiol Cardiovasc Prevent Rehabil & Sports, CH-3010 Bern, Switzerland.
   [Schnyder, Ulrich] Univ Zurich Hosp, Dept Psychiat & Psychotherapy, CH-8091 Zurich, Switzerland.
   [Barth, Juergen] Univ Bern, Inst Social & Prevent Med, Bern, Switzerland.
   [Herbert, Claudia] Oxford Dev Ctr Ltd, Oxford, Oxon, England.
C3 University of Bern; University Hospital of Bern; University of Bern;
   University of Bern; University of Bern; University Hospital of Bern;
   University of Zurich; University Zurich Hospital; University of Bern
RP von Känel, R (corresponding author), Univ Bern, Inselspital, Univ Hosp Bern, Dept Gen Internal Med,Div Psychosomat Med, CH-3010 Bern, Switzerland.
EM roland.vonkaenel@insel.ch
RI Znoj, Hans/C-2727-2014; Schnyder, Ulrich/JGD-0205-2023; Barth,
   Jurgen/F-9987-2011; von Kanel, Roland/B-1811-2019
OI Schnyder, Ulrich/0000-0003-3556-7990; Barth, Jurgen/0000-0001-7096-7178;
   von Kanel, Roland/0000-0002-8929-5129
FU Swiss National Science Foundation [140960]; Teaching and Research
   Directorate, Bern University Hospital, Switzerland
FX The MI-SPRINT study is funded by the Swiss National Science Foundation
   (project number 140960, principal investigator: RvK). Additional
   financial support comes from the Teaching and Research Directorate, Bern
   University Hospital, Switzerland. The funding bodies had no influence on
   the study design, in the writing of the manuscript, and in the decision
   to submit the manuscript for publication.
CR Abbas CC, 2009, INT J PSYCHIAT MED, V39, P359, DOI 10.2190/PM.39.4.b
   [Anonymous], 1997, SKID 1 STRUKTURIERTE
   [Anonymous], 1996, GERMAN TRANSLATION P
   Bach M, 1996, PSYCHOTHER PSYCH MED, V46, P23
   Beck A. T., 1996, BDI 2 BECK DEPRESSIO
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   BLAKE DD, 1995, J TRAUMA STRESS, V8, P75, DOI 10.1007/BF02105408
   Boscarino JA, 2008, PSYCHOSOM MED, V70, P668, DOI 10.1097/PSY.0b013e31817bccaf
   Broadbent E, 2004, J PSYCHOSOM RES, V57, P583, DOI 10.1016/j.jpsychores.2004.03.014
   Bryant RA, 2000, PSYCHOL ASSESSMENT, V12, P61, DOI 10.1037/1040-3590.12.1.61
   Buckley TC, 2001, PSYCHOSOM MED, V63, P585, DOI 10.1097/00006842-200107000-00011
   Cámara RJA, 2011, INFLAMM BOWEL DIS, V17, P1277, DOI 10.1002/ibd.21481
   Cohen BE, 2009, ARCH GEN PSYCHIAT, V66, P1214, DOI 10.1001/archgenpsychiatry.2009.149
   Denollet J, 2005, PSYCHOSOM MED, V67, P89, DOI 10.1097/01.psy.0000149256.81953.49
   DENOLLET J, 1993, PSYCHOL MED, V23, P111, DOI 10.1017/S0033291700038903
   Derogatis L., 1993, SCL-90-R: Administration, scoring, and procedures manual, V3rd
   Dimsdale JE, 2008, J AM COLL CARDIOL, V51, P1237, DOI 10.1016/j.jacc.2007.12.024
   Edmondson D, 2013, PROG CARDIOVASC DIS, V55, P548, DOI 10.1016/j.pcad.2013.03.004
   Edmondson D, 2013, JAMA INTERN MED, V173, P472, DOI 10.1001/jamainternmed.2013.2536
   Edmondson D, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038915
   Edmondson D, 2011, J PSYCHIATR RES, V45, P1621, DOI 10.1016/j.jpsychires.2011.07.004
   Ehlers A, 2003, ARCH GEN PSYCHIAT, V60, P1024, DOI 10.1001/archpsyc.60.10.1024
   Ehrenreich H, 1997, ALCOHOL CLIN EXP RES, V21, P1285, DOI 10.1111/j.1530-0277.1997.tb04450.x
   Enders CK, 2006, PSYCHOSOM MED, V68, P427, DOI 10.1097/01.psy.0000221275.75056.d8
   ENDLER NS, 1990, J PERS SOC PSYCHOL, V58, P844, DOI 10.1037/0022-3514.58.5.844
   Foa EB, 1997, PSYCHOL ASSESSMENT, V9, P445, DOI 10.1037/1040-3590.9.4.445
   Galli U, 2010, EUR J PAIN, V14, P550, DOI 10.1016/j.ejpain.2009.08.011
   Grande G, 2004, PSYCHOTHER PSYCH MED, V54, P413, DOI 10.1055/s-2004-828376
   Guler E, 2009, CLIN CARDIOL, V32, P125, DOI 10.1002/clc.20384
   Gurevich M, 2002, PSYCHOSOMATICS, V43, P259, DOI 10.1176/appi.psy.43.4.259
   Hari R, 2010, J PSYCHOSOM RES, V69, P143, DOI 10.1016/j.jpsychores.2010.04.011
   Hautzinger M., 1994, Beck-Depressions-Inventar (BDI)
   Helfricht S, 2009, J TRAUMA STRESS, V22, P476, DOI 10.1002/jts.20445
   Herbert C, 1995, UNDERSTANDING YOUR R
   Herbert C., 2008, OVERCOMING TRAUMATIC
   Kalesan B, 2012, JACC-CARDIOVASC INTE, V5, P145, DOI 10.1016/j.jcin.2011.11.005
   Kalin W, 1995, DTSCH KURZFORM COPIN
   Klaghofer R, 2001, Z KLIN PSYCHOL PSYCH, V49, P115
   Kubzansky LD, 2007, ARCH GEN PSYCHIAT, V64, P109, DOI 10.1001/archpsyc.64.1.109
   Kubzansky LD, 2009, HEALTH PSYCHOL, V28, P125, DOI 10.1037/0278-6133.28.1.125
   Ladwig KH, 2008, ARCH GEN PSYCHIAT, V65, P1324, DOI 10.1001/archpsyc.65.11.1324
   LAN KKG, 1983, BIOMETRIKA, V70, P659, DOI 10.2307/2336502
   Lazarus R. S., 1984, STRESS APPRAISAL COP, DOI DOI 10.1002/PER.2410010304
   McCrone P, 2003, J TRAUMA STRESS, V16, P519, DOI 10.1023/A:1025722930935
   Mitchell Pamela H, 2003, J Cardiopulm Rehabil, V23, P398, DOI 10.1097/00008483-200311000-00001
   Mittal VA, 2011, PSYCHIAT RES, V189, P158, DOI 10.1016/j.psychres.2011.06.006
   Moss-Morris R, 2002, PSYCHOL HEALTH, V17, P1, DOI 10.1080/08870440290001494
   Orner R, 2003, RECONSTRUCTING EARLY, P36
   PARKER JDA, 1993, EUR J PERSONALITY, V7, P221, DOI 10.1002/per.2410070403
   Rabin R, 2001, ANN MED, V33, P337, DOI 10.3109/07853890109002087
   Rasband W:, IMAGES FREE SOFTWARE
   Reddemann L, 2007, TRAUMA FOLGEN ERKENN
   Roberts NP, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006869.pub2
   Roberts NP, 2009, AM J PSYCHIAT, V166, P293, DOI 10.1176/appi.ajp.2008.08040590
   Rose S., 2002, COCHRANE DB SYST REV, DOI [DOI 10.1002/14651858.CD000560, 10.1002/14651858.CD000560, 10.1002/14651858.CD000560.]
   Rozanski A, 2005, J AM COLL CARDIOL, V45, P637, DOI 10.1016/j.jacc.2004.12.005
   Schelling Gustav, 2008, Prog Brain Res, V167, P229
   Scherrer JF, 2010, AM HEART J, V159, P772, DOI 10.1016/j.ahj.2010.02.033
   Schnyder U, 2002, J TRAUMA STRESS, V15, P487, DOI 10.1023/A:1020922023090
   Schumacher J, 2005, Z KLIN PSYCH PSYCHIA, V53, P16
   Spindler H, 2005, PSYCHOSOM MED, V67, P715, DOI 10.1097/01.psy.0000174995.96183.9b
   Tedstone JE, 2003, CLIN PSYCHOL REV, V23, P409, DOI 10.1016/S0272-7358(03)00031-X
   von Känel R, 2008, PSYCHIAT RES, V158, P363, DOI 10.1016/j.psychres.2006.12.003
   von Känel R, 2007, J PSYCHIATR RES, V41, P744, DOI 10.1016/j.jpsychires.2006.06.009
   von Känel R, 2006, PSYCHOSOM MED, V68, P598, DOI 10.1097/01.psy.0000221229.43272.9d
   von Känel R, 2012, STRESS AND CARDIOVASCULAR DISEASE, P235, DOI 10.1007/978-1-84882-419-5_13
   von Känel R, 2012, SWISS MED WKLY, V142, DOI 10.4414/smw.2012.13502
   von Känel R, 2011, J CARDIOL, V58, P61, DOI 10.1016/j.jjcc.2011.02.007
   von Känel R, 2011, BMC PSYCHIATRY, V11, DOI 10.1186/1471-244X-11-98
   Von Känel R, 2010, WORLD J BIOL PSYCHIA, V11, P141, DOI 10.3109/15622970903449846
   von Känel R, 2010, NEUROIMMUNOMODULAT, V17, P39, DOI 10.1159/000243084
   von Känel R, 2008, J AM COLL CARDIOL, V52, P2163, DOI 10.1016/j.jacc.2008.09.015
   Wagnild G., 1993, Journal of Nursing Measurement, V1, P165
   Wentworth BA, 2013, CARDIOL REV, V21, P16, DOI 10.1097/CRD.0b013e318265343b
   Whitehead DL, 2005, AM J CARDIOL, V96, P1512, DOI 10.1016/j.amjcard.2005.07.070
   Wiedemar L, 2008, HEART LUNG, V37, P113, DOI 10.1016/j.hrtlng.2007.03.005
   Williams JB., 1995, STRUCTURED CLIN INTE
   Xie JP, 2008, CIRCULATION, V118, P491, DOI 10.1161/CIRCULATIONAHA.107.752006
   Zatzick DF, 1997, AM J PSYCHIAT, V154, P1690, DOI 10.1176/ajp.154.12.1690
   Zen AL, 2012, HEALTH PSYCHOL, V31, P194, DOI 10.1037/a0025989
NR 80
TC 39
Z9 39
U1 1
U2 29
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD OCT 11
PY 2013
VL 14
AR 329
DI 10.1186/1745-6215-14-329
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA 235NI
UT WOS:000325725600001
PM 24119487
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bilaç, Ö
   Tahillioglu, A
   Çakir, B
   Kavurma, C
   Önder, A
   Ercan, ES
AF Bilac, Oznur
   Tahillioglu, Akin
   Cakir, Burak
   Kavurma, Canem
   Onder, Arif
   Ercan, Eyup Sabri
TI Is There Any Risk for Metabolic Syndrome in Children and Adolescents
   with Psychiatric Disorders?
SO DUBAI MEDICAL JOURNAL
LA English
DT Article
DE Metabolic syndrome; Weight gain; Blood pressure; Antipsychotics;
   Psychiatric disorder; Bipolar disorder; Children and adolescents;
   Quetiapine; Valproic acid
ID MAJOR DEPRESSIVE DISORDER; ANTIPSYCHOTIC MEDICATIONS;
   CARDIOVASCULAR-DISEASE; 2ND-GENERATION ANTIPSYCHOTICS; NATIONAL-HEALTH;
   ADVERSE EVENTS; DOUBLE-BLIND; WEIGHT-GAIN; SCHIZOPHRENIA; PREVALENCE
AB Objective: We aimed to investigate the risk of antipsychotic drug treatment in the development of metabolic syndrome (MetS) in children and adolescents and to determine which psychiatric disorder is more associated with MetS in the pediatric population. Methods: The sample consisted of 118 children and adolescents (88 used psychotropic medication). The hemogram, fasting blood glucose, lipid profile, weight, and blood pressure levels of all the participants and information regarding medication doses of the patient group at the sixth month of the treatment process were obtained. Results: Bipolar disorder (BPD) was the only psychiatric disorder associated with MetS. Quetiapine and valproic acid were found to have increasing effects on MetS. Weight gain and the increase in systolic and diastolic blood pressure significantly increased the likelihood of MetS. Hierarchical logistic regression analyses revealed that quetiapine increased the risk of MetS through weight gain, and valproic acid increased MetS risk through systolic blood pressure. Conclusion: Especially BPD and psychotropic use in children and adolescents disrupt metabolic regulation and pose a risk for MetS. Determining the risk factors causing MetS, especially in children and adolescents, plays a significant role in preventing mortality and morbidity at advanced ages.
C1 [Bilac, Oznur] Manisa Celal Bayar Univ, Dept Child & Adolescent Psychiat, Manisa, Turkiye.
   [Tahillioglu, Akin] Bakircay Univ, Cigli Reg Educ Hosp, Dept Child & Adolescent Psychiat, Izmir, Turkiye.
   [Cakir, Burak] Usak Educ & Res Hosp, Dept Child & Adolescent Psychiat, Usak, Turkiye.
   [Kavurma, Canem] Dr Behcet Uz Pediat Dis & Surg Training & Res Hosp, Dept Child & Adolescent Psychiat, Izmir, Turkiye.
   [Onder, Arif] Akdeniz Univ, Dept Child & Adolescent Psychiat, Antalya, Turkiye.
   [Ercan, Eyup Sabri] Ege Univ, Dept Child & Adolescent Psychiat, Izmir, Turkiye.
C3 Celal Bayar University; Izmir University of Bakircay; Akdeniz
   University; Ege University
RP Çakir, B (corresponding author), Usak Educ & Res Hosp, Dept Child & Adolescent Psychiat, Usak, Turkiye.
RI Tahıllıoğlu, Akın/HLG-4928-2023; Bilac, Oznur/GOH-0097-2022; Onder,
   Arif/AAJ-6947-2020
OI Onder, Arif/0000-0003-0571-9295
CR Al-Hamad D, 2017, TRANSL PEDIATR, V6, P397, DOI 10.21037/tp.2017.10.02
   [Anonymous], 2011, AACAP PRACTICE PARAM, P1
   Bai YM, 2016, BMC PSYCHIATRY, V16, DOI 10.1186/s12888-016-1143-8
   Beyazyüz M, 2013, PSYCHIAT INVEST, V10, P148, DOI 10.4306/pi.2013.10.2.148
   Buchan DS, 2012, J PUBLIC HEALTH RES, V1, P59, DOI 10.4081/jphr.2012.e11
   Carton L, 2015, CURR PHARM DESIGN, V21, P3280, DOI 10.2174/1381612821666150619092903
   Celik GG., 2011, PSIKIYATRIDE GUNCEL, V3, P232
   Cook S, 2008, J PEDIATR, V152, P165, DOI 10.1016/j.jpeds.2007.06.004
   Correll CU, 2006, J AM ACAD CHILD PSY, V45, P771, DOI 10.1097/01.chi.0000220851.94392.30
   Esposito K, 2012, DIABETES CARE, V35, P2402, DOI 10.2337/dc12-0336
   Fonseka Trehani M, 2016, Mol Neuropsychiatry, V2, P1, DOI 10.1159/000441521
   Ford ES, 2008, DIABETES CARE, V31, P1898, DOI 10.2337/dc08-0423
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Goeb JL, 2010, ENCEPHALE, V36, P242, DOI 10.1016/j.encep.2009.10.008
   Gokler B., 2004, Cocuk Genclik Ruh Sagligi Dergisi, V11, P109
   Grover Sandeep, 2013, Indian J Psychol Med, V35, P167, DOI 10.4103/0253-7176.116247
   Henderson DC, 2015, LANCET PSYCHIAT, V2, P452, DOI 10.1016/S2215-0366(15)00115-7
   Higgins Victoria, 2017, EJIFCC, V28, P25
   Hiles SA, 2012, PSYCHOL MED, V42, P2015, DOI 10.1017/S0033291712000128
   Jerrell JM, 2008, HUM PSYCHOPHARM CLIN, V23, P283, DOI 10.1002/hup.932
   Kaufman J, 1997, J AM ACAD CHILD PSY, V36, P980, DOI 10.1097/00004583-199707000-00021
   Kemp DE, 2010, J CLIN PSYCHIAT, V71, P1138, DOI 10.4088/JCP.09m05159gre
   Ko YK, 2013, CLIN PSYCHOPHARM NEU, V11, P80, DOI 10.9758/cpn.2013.11.2.80
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lasserre AM, 2014, JAMA PSYCHIAT, V71, P880, DOI 10.1001/jamapsychiatry.2014.411
   Li C, 2019, J CLIN PSYCHIAT, V80, DOI 10.4088/JCP.18m12422
   Maayan L, 2011, J CHILD ADOL PSYCHOP, V21, P517, DOI 10.1089/cap.2011.0015
   Marazziti D, 2014, CNS SPECTRUMS, V19, P293, DOI 10.1017/S1092852913000667
   Martino F, 2014, INT J CARDIOL, V177, P455, DOI 10.1016/j.ijcard.2014.09.020
   Masi G, 2011, DRUGS, V71, P179, DOI 10.2165/11585350-000000000-00000
   McIntyre RS, 2009, EVID-BASED MENT HEAL, V12, P93, DOI 10.1136/ebmh.12.3.93
   McIntyre RS, 2010, CNS DRUGS, V24, P741, DOI 10.2165/11533280-000000000-00000
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P295, DOI 10.1093/schbul/sbs082
   MITCHELL J, 1988, J AM ACAD CHILD PSY, V27, P12, DOI 10.1097/00004583-198801000-00004
   Mohite S, 2020, CLIN PSYCHOPHARM NEU, V18, P279, DOI 10.9758/cpn.2020.18.2.279
   Moreno C, 2010, BIPOLAR DISORD, V12, P172, DOI 10.1111/j.1399-5618.2010.00797.x
   Newcomer JW, 2007, J CLIN PSYCHIAT, V68, P8
   Olfson M, 2015, JAMA PSYCHIAT, V72, P867, DOI 10.1001/jamapsychiatry.2015.0500
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Patel NC, 2007, J CHILD ADOL PSYCHOP, V17, P303, DOI 10.1089/cap.2006.0037
   Raeder MB, 2006, J CLIN PSYCHIAT, V67, P1974, DOI 10.4088/JCP.v67n1219
   Révész D, 2014, J CLIN ENDOCR METAB, V99, P4607, DOI 10.1210/jc.2014-1851
   Ronsley R, 2015, CAN J PSYCHIAT, V60, P441, DOI 10.1177/070674371506001005
   Safer DJ, 2004, J CLIN PSYCHOPHARM, V24, P429, DOI 10.1097/01.jcp.0000130558.86125.5b
   Sahpolat M, 2021, NORD J PSYCHIAT, V75, P73, DOI 10.1080/08039488.2020.1815080
   Siervo M, 2014, J ALZHEIMERS DIS, V41, P151, DOI 10.3233/JAD-132279
   Sikich L, 2008, AM J PSYCHIAT, V165, P1420, DOI 10.1176/appi.ajp.2008.08050756
   Titmuss AT, 2016, J PAEDIATR CHILD H, V52, P928, DOI 10.1111/jpc.13190
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Walkup J, 2009, J AM ACAD CHILD PSY, V48, P961, DOI 10.1097/CHI.0b013e3181ae0a08
NR 52
TC 0
Z9 0
U1 0
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
EI 2571-726X
J9 DUBAI MED J
JI Dubai Med. J.
PD DEC
PY 2023
VL 6
IS 4
BP 261
EP 273
DI 10.1159/000533470
EA SEP 2023
PG 13
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA AA5Y5
UT WOS:001069791400001
OA gold
DA 2025-06-11
ER

PT J
AU Trief, PM
   Cibula, D
   Delahanty, LM
   Weinstock, RS
AF Trief, Paula M.
   Cibula, Donald
   Delahanty, Linda M.
   Weinstock, Ruth S.
TI Depression, Stress, and Weight Loss in Individuals with Metabolic
   Syndrome in SHINE, a DPP Translation Study
SO OBESITY
LA English
DT Article
ID DIABETES PREVENTION PROGRAM; LIFE-STYLE INTERVENTION; PREDICTORS;
   OUTCOMES; ADULTS
AB ObjectiveTo examine the relationships between elevated depression symptoms (EDS) or stress and weight loss in SHINE, a telephonic, primary-care based, translation of the Diabetes Prevention Program.
   MethodsN=257 adults with metabolic syndrome were randomized to individual (IC) or group (CC) phone participation. Weight, depression, anti-depressant use (ADMs), and stress (baseline, 6 months, 1 and 2 years) were assessed. Univariate analyses used linear and logistic regression, t tests for continuous variables and exact tests for categorical variables. Stratified analyses assessed modifiers of effects of depression/stress on weight loss.
   ResultsApproximately 35% reported EDS, with no change over time. Approximately 28% of all participants used ADMs. Participants with EDS had lower mean % weight loss and a smaller % who achieved 5% weight loss. Participants with EDS were less likely to be completers (40.1% vs. 61.5%, P=0.002), coached (48.0% vs. 60.7%, P=0.049), or log diet/activity (19.4% vs. 42.7%, P<0.001), behaviors related to weight loss. Results were similar for high stress. ADM use had no independent effect on weight loss.
   ConclusionsIndividuals with metabolic syndrome and EDS and/or high stress were less likely to lose significant weight. Pre-intervention depression and stress screening to intervene may improve weight loss.
C1 [Trief, Paula M.] SUNY Upstate Med Univ, Dept Psychiat & Behav Sci, New York, NY 13210 USA.
   [Trief, Paula M.; Weinstock, Ruth S.] SUNY Upstate Med Univ, Dept Med, New York, NY USA.
   [Cibula, Donald] SUNY Upstate Med Univ, Dept Publ Hlth & Prevent Med, New York, NY USA.
   [Delahanty, Linda M.] Massachusetts Gen Hosp, Diabet Res Ctr, Boston, MA 02114 USA.
   [Delahanty, Linda M.] Harvard Univ, Dept Med, Cambridge, MA 02138 USA.
C3 State University of New York (SUNY) System; State University of New York
   (SUNY) Upstate Medical Center; State University of New York (SUNY)
   System; State University of New York (SUNY) Upstate Medical Center;
   State University of New York (SUNY) System; State University of New York
   (SUNY) Upstate Medical Center; Harvard University; Harvard University
   Medical Affiliates; Massachusetts General Hospital; Harvard University
RP Trief, PM (corresponding author), SUNY Upstate Med Univ, Dept Psychiat & Behav Sci, New York, NY 13210 USA.
EM triefp@upstate.edu
RI Trief, Paula/T-6116-2019
OI Trief, Paula/0000-0002-2827-5722
FU National Institutes of Health [R18-DK078553]
FX Funding agencies: Study supported by grant R18-DK078553, National
   Institutes of Health.
CR Aikens JE, 2012, DIABETES CARE, V35, P2472, DOI 10.2337/dc12-0181
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Ali MK, 2012, HEALTH AFFAIR, V31, P67, DOI 10.1377/hlthaff.2011.1009
   [Anonymous], DIABETES PREVENTION
   Boltri JM, 2011, J NATL MED ASSOC, V103, P194, DOI 10.1016/S0027-9684(15)30301-1
   Bray GA, 2009, LANCET, V374, P1677, DOI 10.1016/S0140-6736(09)61457-4
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Delahanty LM, 2013, DIABETES CARE, V36, P34, DOI 10.2337/dc12-0733
   Elder CR, 2012, INT J OBESITY, V36, P86, DOI 10.1038/ijo.2011.60
   Kim KHC, 2009, HEALTH PSYCHOL, V28, P131, DOI 10.1037/a0012648
   Knowler WC, 2002, NEW ENGL J MED, V346, P393, DOI 10.1056/nejmoa012512
   Lewinsohn PM, 1997, PSYCHOL AGING, V12, P277, DOI 10.1037/0882-7974.12.2.277
   Moroshko I, 2011, OBES REV, V12, P912, DOI 10.1111/j.1467-789X.2011.00915.x
   Mozumdar A, 2011, DIABETES CARE, V34, P216, DOI 10.2337/dc10-0879
   Price DW, 2013, DIABETES CARE, V36, P216, DOI 10.2337/dc12-0293
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Rubin RR, 2008, DIABETES CARE, V31, P420, DOI 10.2337/dc07-1827
   Rubin RR, 2005, DIABETES CARE, V28, P830
   Stubbs J, 2011, OBES REV, V12, P688, DOI 10.1111/j.1467-789X.2011.00883.x
   Svetkey LP, 2012, OBESITY, V20, P1820, DOI 10.1038/oby.2011.88
   Tsai AG, 2014, OBESITY, V22, P1016, DOI 10.1002/oby.20648
   Wadden TA, 2014, DIABETES CARE, V37, P1544, DOI 10.2337/dc13-1928
   Weinstock RS, 2013, J GEN INTERN MED, V28, P1620, DOI 10.1007/s11606-013-2529-7
   West DS, 2008, OBESITY, V16, P1413, DOI 10.1038/oby.2008.224
   Wing RR, 2004, OBES RES, V12, P1426
NR 25
TC 33
Z9 39
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD DEC
PY 2014
VL 22
IS 12
BP 2532
EP 2538
DI 10.1002/oby.20916
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA AU1XA
UT WOS:000345409500012
PM 25251749
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Roettger, ME
   Tan, J
   Houle, B
   Najman, JM
   McGee, T
AF Roettger, Michael E.
   Tan, Jolene
   Houle, Brian
   Najman, Jake M.
   McGee, Tara
TI Parental imprisonment, childhood behavioral problems, and adolescent and
   young adult cardiometabolic risk: results from a prospective Australian
   birth cohort study
SO HEALTH & JUSTICE
LA English
DT Article
DE Parental imprisonment; Behavioral problems; Body mass index; Systolic
   blood pressure; Diastolic blood pressure; Waist circumference;
   Cardiometabolic risk
ID PATERNAL INCARCERATION; MENTAL-HEALTH; FAMILY-MEMBER; MATERNAL
   INCARCERATION; SEX-DIFFERENCES; BLOOD-PRESSURE; DISPARITIES; STRESS;
   ASSOCIATIONS; FATHERS
AB ObjectivesRecent studies have demonstrated that parental imprisonment (PI) is associated with cardiometabolic risk later in life. However, underlying risk factors for these associations have not previously been explored. Using a life course framework, the present study explores how early childhood emotional and behavioral dysregulation and PI may be associated with progressive cardiometabolic risk factors in adolescence and young adulthood among male and female respondents in an Australian birth cohort.MethodsThe study follows a subset of 7,223 live, singleton births from 1981 to 1984 in Brisbane, Australia where data was collected on parental imprisonment at ages 5 & 14 and behaviors from the Child Behavioral Checklist (CBCL) at age 5. Our sample examines 1,884 males and 1,758 females whose mothers completed prenatal, age 5, and age 14 interviews and respondents completed one or more interviews at a health clinic at ages 14, 21, and 30. Multivariate regression was used to examine cross-sectional results, while individual growth models examined longitudinal patterns.ResultsDividing the analysis by sex, we examined how parental imprisonment was potentially mediated or moderated by CBCL subscale measures for aggression, social-attention-thought (SAT) disorders, internalizing, and depression. No associations were found among male respondents. Among female respondents, controlling for these behaviors, there was a significant association between parental imprisonment and higher systolic blood pressure at age 30, while all CBCL measures were found to moderate waist circumference at age 30 and BMI at ages 14, 21, and/or 30. Using individual growth curve modelling, we observed the increased CBCL aggression and SAT scores were increasingly associated with higher BMI as respondents aged in adulthood.ConclusionsUsing prospective cohort data, our results suggest that PI and emotional and behavioral dysregulation are associated with BMI, systolic blood pressure, and waist circumference in females, along with potentially increasing levels of cardiometabolic risk, as measured by increased BMI, from age 14 through age 30. The result is suggestive of the importance of examining early emotional/behavioral problems and PI as joint risk factors for developing cardiometabolic risk factors that may progress into cardiometabolic diseases at later stages in the life course.
C1 [Roettger, Michael E.; Tan, Jolene; Houle, Brian] Australian Natl Univ, Sch Demog, 146 Ellery Crescent, Acton, ACT 2601, Australia.
   [Houle, Brian] Univ Witwatersrand, Fac Hlth Sci, Sch Publ Hlth, MRC Wits Rural Publ Hlth & Hlth Transit Res Unit A, Johannesburg, South Africa.
   [Najman, Jake M.] Univ Queensland, Sch Publ Hlth, Publ Hlth Bldg, Herston 4006, Australia.
   [McGee, Tara] Griffith Univ, Sch Criminol & Criminal Justice, 176 Messines Ridge Rd, Mt Gravatt, Qld 4122, Australia.
C3 Australian National University; University of Witwatersrand; University
   of Queensland; Griffith University; Griffith University - Mount Gravatt
   Campus
RP Roettger, ME (corresponding author), Australian Natl Univ, Sch Demog, 146 Ellery Crescent, Acton, ACT 2601, Australia.
EM mike.roettger@anu.edu.au
RI McGee, Tara Renae/IZQ-4686-2023; Tan, Jolene/GXF-8878-2022; Najman,
   Jackob/B-1527-2008; Roettger, Michael/ABA-6927-2020
OI Tan, Jolene/0000-0003-4968-3482; Roettger, Michael/0000-0002-8253-5927
CR Amato MC, 2013, J ENDOCRINOL INVEST, V36, P537, DOI 10.3275/8943
   Arditti JA, 2015, CRIMINOL PUBLIC POL, V14, P169, DOI 10.1111/1745-9133.12117
   Austin MK, 2022, AM J HUM BIOL, V34, DOI 10.1002/ajhb.23691
   Axelson A, 2020, CHILD YOUTH SERV REV, V110, DOI 10.1016/j.childyouth.2020.104802
   Ben-Shlomo Y, 2002, INT J EPIDEMIOL, V31, P285, DOI 10.1093/ije/31.2.285
   Beresford S, 2020, BMJ PAEDIATR OPEN, V4, DOI 10.1136/bmjpo-2018-000275
   Bertele S, 2022, FRONT PSYCHIATRY, V13, DOI 10.3389/fpsyt.2022.1002143
   Besemer K. L., 2019, Handbook on Children With Incarcerated Parents: Research Policy and Practice, P65
   Besemer KL, 2019, PALGRAVE STUD PRISON, P479, DOI 10.1007/978-3-030-12744-2_23
   Boch SJ, 2018, J FORENSIC NURS, V14, P61, DOI 10.1097/JFN.0000000000000201
   Boch SJ, 2015, BIOL RES NURS, V17, P574, DOI 10.1177/1099800414564011
   Boen CE, 2023, DEMOGRAPHY, V60, P1815, DOI 10.1215/00703370-11057546
   Boen CE, 2020, J HEALTH SOC BEHAV, V61, P290, DOI 10.1177/0022146520936208
   Branigan AR, 2019, PUBLIC HEALTH REP, V134, P363, DOI 10.1177/0033354919854448
   Carcel C, 2024, NAT MED, V30, P61, DOI 10.1038/s41591-023-02738-1
   Coleman J, 2021, BMC PUBLIC HEALTH, V21, DOI 10.1186/s12889-021-10237-6
   Conen D, 2007, EUR HEART J, V28, P2937, DOI 10.1093/eurheartj/ehm400
   Connelly PJ, 2021, CAN J CARDIOL, V37, P699, DOI 10.1016/j.cjca.2021.02.005
   Connors K, 2020, AM J PUBLIC HEALTH, V110, pS71, DOI 10.2105/AJPH.2019.305397
   Darsini D, 2020, J PUBLIC HEALTH RES, V9, P94, DOI 10.4081/jphr.2020.1811
   Das SK, 2020, ATHEROSCLEROSIS, V311, P91, DOI 10.1016/j.atherosclerosis.2020.09.001
   Davis E, 2023, J CARDIOVASC NURS, V38, P168, DOI 10.1097/JCN.0000000000000888
   Del Toro Juan, 2024, Am J Epidemiol, DOI 10.1093/aje/kwae457
   Del Toro J, 2022, J AM ACAD CHILD PSY, V61, P423, DOI 10.1016/j.jaac.2021.08.005
   Dennison S, 2013, AUST J SOC ISSUES, V48, P339, DOI 10.1002/j.1839-4655.2013.tb00286.x
   Deschênes SS, 2021, J AM HEART ASSOC, V10, DOI 10.1161/JAHA.120.019013
   Enns PK., 2019, Socius: Sociological Research for a Dynamic World, V5, DOI DOI 10.1177/2378023119829332
   Foster H, 2007, SOC PROBL, V54, P399, DOI 10.1525/sp.2007.54.4.399
   Foster H, 2017, PREV MED, V99, P43, DOI 10.1016/j.ypmed.2017.01.018
   Foster H, 2015, ANNU REV SOCIOL, V41, P135, DOI 10.1146/annurev-soc-073014-112437
   Foster H, 2013, SOC SCI RES, V42, P650, DOI 10.1016/j.ssresearch.2013.01.008
   Gifford EJ, 2019, JAMA NETW OPEN, V2, DOI 10.1001/jamanetworkopen.2019.10005
   Giordano P.C., 2010, Legacies of crime: A follow-up of the children of highly delinquent girls and boys
   Giordano PC, 2015, CRIMINOL PUBLIC POL, V14, P157, DOI 10.1111/1745-9133.12118
   Godoy LC, 2021, JAMA CARDIOL, V6, P228, DOI 10.1001/jamacardio.2020.6050
   Gonzalez A, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-755
   Graham J. W., 2012, Missing data: Analysis and design, DOI [10.1007/978-1-4614-4018-5, DOI 10.1007/978-1-4614-4018-5]
   Greeson JKP, 2014, J INTERPERS VIOLENCE, V29, P536, DOI 10.1177/0886260513505217
   Heard-Garris N, 2018, PEDIATRICS, V142, DOI 10.1542/peds.2017-4314
   Jackson DB, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph191811710
   Jackson DB, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18073384
   Jackson DB, 2017, J PEDIATR-US, V185, P211, DOI 10.1016/j.jpeds.2017.03.026
   Järvinen A, 2024, J CHILD PSYCHOL PSYC, V65, P1590, DOI 10.1111/jcpp.14003
   Johnson EI, 2023, ANNU REV CLIN PSYCHO, V19, P437, DOI 10.1146/annurev-clinpsy-080921-081447
   Kerker BD, 2015, ACAD PEDIATR, V15, P510, DOI 10.1016/j.acap.2015.05.005
   Kincaid S., 2019, Crest
   Kivimäki M, 2022, NAT REV ENDOCRINOL, DOI 10.1038/s41574-022-00746-8
   Korczak DJ, 2013, DEV MED CHILD NEUROL, V55, P980, DOI 10.1111/dmcn.12168
   Le GT, 2019, J ADOLESCENT HEALTH, V64, P398, DOI 10.1016/j.jadohealth.2018.09.028
   Lee H, 2014, AM J PUBLIC HEALTH, V104, P421, DOI 10.2105/AJPH.2013.301504
   Lee RD, 2013, PEDIATRICS, V131, pE1188, DOI 10.1542/peds.2012-0627
   Leigh A, 2020, ECON REC, V96, P187, DOI 10.1111/1475-4932.12536
   Leigh A, 2020, AUST ECON HIST REV, V60, P148, DOI 10.1111/aehr.12194
   Li Q, 2024, POPUL RES POLICY REV, V43, DOI 10.1007/s11113-024-09908-0
   Louise S, 2012, PEDIATR OBES, V7, P319, DOI 10.1111/j.2047-6310.2012.00047.x
   Louise S, 2012, PREV MED, V54, P345, DOI 10.1016/j.ypmed.2012.03.004
   Mamun AA, 2009, OBESITY, V17, P761, DOI 10.1038/oby.2008.594
   Mauvais-Jarvis F, 2020, LANCET, V396, P565, DOI 10.1016/S0140-6736(20)31561-0
   McClelland MM, 2017, FUTURE CHILD, V27, P33, DOI 10.1353/foc.2017.0002
   Metcalfe RE, 2023, J CHILD ADOLES TRAUM, V16, P329, DOI 10.1007/s40653-022-00490-1
   Murray J., 2014, EFFECTS PARENTAL INC
   Murray J, 2008, DEV PSYCHOPATHOL, V20, P273, DOI 10.1017/S0954579408000138
   Najman JM, 2015, INT J EPIDEMIOL, V44, P78, DOI 10.1093/ije/dyu234
   Najman JM, 2005, INT J EPIDEMIOL, V34, P992, DOI 10.1093/ije/dyi119
   Najman JM, 1997, J AM ACAD CHILD PSY, V36, P1357, DOI 10.1097/00004583-199710000-00017
   Niño MD, 2020, ANN EPIDEMIOL, V43, P18, DOI 10.1016/j.annepidem.2020.02.002
   Roettger M, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2020-038445
   Roettger ME, 2023, SSM-POPUL HLTH, V22, DOI 10.1016/j.ssmph.2023.101425
   Roettger ME, 2022, SSM-POPUL HLTH, V18, DOI 10.1016/j.ssmph.2022.101107
   Roettger ME, 2018, AM BEHAV SCI, V62, P1545, DOI 10.1177/0002764218796995
   Roettger ME, 2012, AM J EPIDEMIOL, V175, P636, DOI 10.1093/aje/kwr409
   Roettger ME, 2011, ADDICTION, V106, P121, DOI 10.1111/j.1360-0443.2010.03110.x
   Rosen DL, 2008, AM J PUBLIC HEALTH, V98, P2278, DOI 10.2105/AJPH.2007.121855
   Rothman KJ, 2013, INT J EPIDEMIOL, V42, P1012, DOI 10.1093/ije/dys223
   Royston P, 2011, J STAT SOFTW, V45, P1, DOI 10.18637/jss.v045.i04
   Ryan JE, 2023, AM J PREV MED, V65, P505, DOI 10.1016/j.amepre.2023.03.008
   Saiepour N, 2019, J PSYCHIATR RES, V110, P127, DOI 10.1016/j.jpsychires.2018.12.022
   Shehadeh A, 2016, CHILD ADOL MENT H-UK, V21, P154, DOI 10.1111/camh.12111
   Smith DT, 2018, AM J MENS HEALTH, V12, P78, DOI 10.1177/1557988316630953
   Suglia SF, 2020, J PEDIATR-US, V219, P267, DOI 10.1016/j.jpeds.2019.12.063
   Swisher RR, 2012, J RES ADOLESCENCE, V22, P597, DOI 10.1111/j.1532-7795.2012.00810.x
   Sykes BL, 2014, ANN AM ACAD POLIT SS, V654, DOI 10.1177/0002716214526345
   Tang AL, 2023, PSYCHONEUROENDOCRINO, V152, DOI 10.1016/j.psyneuen.2023.106084
   Tasca M, 2011, CRIM JUSTICE BEHAV, V38, P231, DOI 10.1177/0093854810391632
   Thornberry TP, 2020, J DEV LIFE-COURSE CR, V6, P381, DOI 10.1007/s40865-020-00150-8
   Thornberry TP, 2009, CRIMINOLOGY, V47, P297, DOI 10.1111/j.1745-9125.2009.00153.x
   Ting MH, 2022, ASIAN J CRIMINOL, V17, P449, DOI 10.1007/s11417-022-09371-w
   Tither JM, 2008, DEV PSYCHOL, V44, P1409, DOI 10.1037/a0013065
   Tung EL, 2023, JAMA CARDIOL, V8, P927, DOI 10.1001/jamacardio.2023.2672
   Turney K, 2015, SOC SERV REV, V89, P335, DOI 10.1086/681704
   Turney K, 2014, J HEALTH SOC BEHAV, V55, P302, DOI 10.1177/0022146514544173
   van de Weijer SGA, 2021, SSM-POPUL HLTH, V14, DOI 10.1016/j.ssmph.2021.100810
   van de Weijer SGA, 2018, J DEV LIFE-COURSE CR, V4, P148, DOI 10.1007/s40865-017-0078-1
   Wakefield S, 2011, CRIMINOL PUBLIC POL, V10, P793, DOI 10.1111/j.1745-9133.2011.00740.x
   White BA, 2016, J CRIM JUST, V44, P89, DOI 10.1016/j.jcrimjus.2015.12.006
   Wildeman C, 2021, ANNU REV SOCIOL, V47, P543, DOI 10.1146/annurev-soc-081320-113303
   Wildeman C, 2018, EPIDEMIOL REV, V40, P146, DOI 10.1093/epirev/mxx013
   Wildeman C, 2017, CRIMINOLOGY, V55, P32, DOI 10.1111/1745-9125.12124
   Wildeman C, 2012, AM SOCIOL REV, V77, P216, DOI 10.1177/0003122411436234
   Wildeman C, 2010, SOC FORCES, V89, P285, DOI 10.1353/sof.2010.0055
   Williams GM, 1998, PEDIATRICS, V102, DOI 10.1542/peds.102.1.e11
   Wilson DK, 2009, J PEDIATR PSYCHOL, V34, P231, DOI 10.1093/jpepsy/jsn137
   Yang YC, 2021, P NATL ACAD SCI USA, V118, DOI 10.1073/pnas.2020167118
   Yang YC, 2016, P NATL ACAD SCI USA, V113, P578, DOI 10.1073/pnas.1511085112
   Young R, 2015, J MARRIAGE FAM, V77, P277, DOI 10.1111/jomf.12144
NR 105
TC 0
Z9 0
U1 1
U2 1
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2194-7899
J9 HEAL JUSTICE
JI Health Justice
PD APR 30
PY 2025
VL 13
IS 1
AR 29
DI 10.1186/s40352-025-00329-5
PG 20
WC Criminology & Penology; Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Criminology & Penology; Public, Environmental & Occupational Health
GA 2CO2W
UT WOS:001479422100001
PM 40304817
OA Green Accepted, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Asthana, NK
   Mehaffey, E
   Sewell, DD
AF Asthana, Niraj K.
   Mehaffey, Eamonn
   Sewell, Daniel D.
TI COVID-19 Associated Suicidal Ideation in Older Adults: Two Case Reports
   With a Review of the Literature
SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Review
DE COVID-19; older adults; case report; mental health; ECT; suicidal
   ideation; social isolation
ID MENTAL-HEALTH; EMOTIONAL RESPONSES; METABOLIC SYNDROME; PERCEIVED
   STRESS; UNITED-STATES; DEPRESSION; IMPACT; LIFE; LONELINESS; PEOPLE
AB The COVID-19 pandemic may profoundly harm the mental health and emotional well-being of many older adults. Public health interventions to minimize the spread of the virus have had the unintended consequences of worsening social isolation, financial stress, and unemployment. Results of early research efforts assessing the impact of these interventions on the mental health of older adults have been mixed. Available findings suggest that a subset of community dwelling older adults have been less negatively impacted than younger adults, while people of color, the poor, residents of nursing homes and other communal living environments, and those living with dementia and their caregivers are more likely to suffer from COVID-related health problems. This manuscript describes two older adults for whom COVID-19 associated stresses caused significant worsening in their psychiatric illnesses, including the emergence of suicidal ideation, summarizes the literature on the impact of interactions between psychosocial stresses and biological factors on the mental health and well-being of older adults, and discusses interventions to help older adults whose mental health has worsened due to COVID-19. Timely and accurate diagnosis, prompt provision of individualized care using both pharmacologic and psychotherapeutic interventions, adoption of new technologies that permit care to be provided safely at a distance and which allow for virtual social interactions, coupled with ongoing advocacy for policy changes that address significant health care disparities and provide older adults continued access to health care and relief from financial hardship, will help older adults remaining as healthy as possible during the pandemic.
C1 [Asthana, Niraj K.; Mehaffey, Eamonn; Sewell, Daniel D.] Univ Calif San Diego, 350 Dickinson St,Suite 221, La Jolla, CA 92093 USA.
C3 University of California System; University of California San Diego
RP Sewell, DD (corresponding author), Univ Calif San Diego, 350 Dickinson St,Suite 221, La Jolla, CA 92093 USA.
EM dsewell@health.ucsd.edu
CR Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   Applegate WB, 2020, J AM GERIATR SOC, V68, P681, DOI 10.1111/jgs.16426
   Arbaje A, CORONAVIRUS COVID 19
   Armitage R, 2020, LANCET PUBLIC HEALTH, V5, pE256, DOI 10.1016/S2468-2667(20)30061-X
   Aziz R, 2013, PSYCHIAT CLIN N AM, V36, P497, DOI 10.1016/j.psc.2013.08.001
   Barnes DE, 2012, ARCH GEN PSYCHIAT, V69, P493, DOI 10.1001/archgenpsychiatry.2011.1481
   Bedlin H., 2020, WHAT C HAS DONE COVI
   Centers for Medicare & Medicaid Services, PHYS OTH CLIN CMS FL
   Charles ST, 2010, ANNU REV PSYCHOL, V61, P383, DOI 10.1146/annurev.psych.093008.100448
   Charles ST, 2008, PSYCHOL AGING, V23, P495, DOI 10.1037/a0013284
   Classen TJ, 2012, HEALTH ECON, V21, P338, DOI 10.1002/hec.1719
   Clay R. A., 2020, COVID 19 ISNT JUST D
   Coe E H., 2020, Returning to resilience: The impact of COVID-19 on mental health and substance use
   Cohen-Mansfield J, 2016, INT PSYCHOGERIATR, V28, P557, DOI 10.1017/S1041610215001532
   *CTR STUD TRAUM ST, MENT HLTH BEH GUID R
   Cubanski Juliete., 2018, How Many Seniors Live in Poverty
   Czeisler MÉ, 2020, MMWR-MORBID MORTAL W, V69, P1049, DOI [10.15585/mmwr.mm6932a1, 10.1101/2020.04.22.20076141v1]
   Du X, 2015, FRONT PSYCHIATRY, V6, DOI 10.3389/fpsyt.2015.00032
   Duman RS, 2012, SCIENCE, V338, P68, DOI 10.1126/science.1222939
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   Eghigian G., 2020, PSYCHIAT TIMES
   Eshel Y, 2016, AM J GERIAT PSYCHIAT, V24, P644, DOI 10.1016/j.jagp.2016.03.002
   Fiske A, 2009, ANNU REV CLIN PSYCHO, V5, P363, DOI 10.1146/annurev.clinpsy.032408.153621
   Forbes MK, 2019, CLIN PSYCHOL SCI, V7, P900, DOI 10.1177/2167702619859337
   Fountain-Zaragoza S, 2017, FRONT AGING NEUROSCI, V9, DOI 10.3389/fnagi.2017.00011
   Galea S, 2020, JAMA INTERN MED, V180, P817, DOI 10.1001/jamainternmed.2020.1562
   Geiger PJ, 2016, MINDFULNESS, V7, P296, DOI 10.1007/s12671-015-0444-1
   Gellis ZD, 2014, J AM GERIATR SOC, V62, P889, DOI 10.1111/jgs.12776
   Gellis Zvi D, 2010, Best Pract Ment Health, V6, P1
   Gerst-Emerson K, 2015, AM J PUBLIC HEALTH, V105, P1013, DOI 10.2105/AJPH.2014.302427
   Gunnell D, 2020, LANCET PSYCHIAT, V7, P468, DOI 10.1016/S2215-0366(20)30171-1
   Hamm ME, 2020, AM J GERIAT PSYCHIAT, V28, P924, DOI 10.1016/j.jagp.2020.06.013
   Hollander JE, 2020, NEW ENGL J MED, V382, P1679, DOI 10.1056/NEJMp2003539
   Inter-Agency Standing Committee Mental Health and Psychosocial Support (MHPSS) Reference Group, 2020, BRIEF NOT ADDR MENT
   Jeste DV, 2020, JAMA PSYCHIAT, V77, P553, DOI 10.1001/jamapsychiatry.2020.0027
   Justice NJ, 2018, NEUROBIOL STRESS, V8, P127, DOI 10.1016/j.ynstr.2018.04.002
   Kahn JR, 2006, J HEALTH SOC BEHAV, V47, P17, DOI 10.1177/002214650604700102
   Kaplan D., GERIATRICS
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Kwag KH, 2011, INT J AGING HUM DEV, V72, P137, DOI 10.2190/AG.72.2.c
   Larson EB., 2020, SENIORS CAN BUILD RE
   Levy Helen, 2015, RSF, V1, P55
   Luo Y, 2012, SOC SCI MED, V74, P907, DOI 10.1016/j.socscimed.2011.11.028
   Maydych V, 2019, FRONT NEUROSCI-SWITZ, V13, DOI 10.3389/fnins.2019.00384
   Mbakwem Amam, 2016, Card Fail Rev, V2, P110, DOI 10.15420/cfr.2016:21:1
   McEwen BS, 2013, NEURON, V79, P16, DOI 10.1016/j.neuron.2013.06.028
   Milner A, 2014, PSYCHOL MED, V44, P909, DOI 10.1017/S0033291713001621
   Moulton CD, 2015, LANCET DIABETES ENDO, V3, P461, DOI 10.1016/S2213-8587(15)00134-5
   Nasreddine ZS, 2005, J AM GERIATR SOC, V53, P695, DOI 10.1111/j.1532-5415.2005.53221.x
   Nie X, 2018, NEURON, V99, P464, DOI 10.1016/j.neuron.2018.06.035
   Nordt C, 2015, LANCET PSYCHIAT, V2, P239, DOI 10.1016/S2215-0366(14)00118-7
   Nousen EK, 2013, NEUROENDOCRINOLOGY, V98, P254, DOI 10.1159/000355632
   Oyesanya M, 2015, WORLD J PSYCHIATR, V5, P243, DOI 10.5498/wjp.v5.i2.243
   Pan KY, 2021, LANCET PSYCHIAT, V8, P121, DOI 10.1016/S2215-0366(20)30491-0
   Parker G, 2016, INT PSYCHOGERIATR, V28, P11, DOI 10.1017/S1041610215001210
   Personal Capital, 2020, HAS COVID 19 IMP OUR
   Purcell PJ, 2018, EMPLOYMENT OLDER AGE
   Rafiey H, 2016, CLIN INTERV AGING, V11, P1791, DOI 10.2147/CIA.S122122
   Reger MA, 2020, JAMA PSYCHIAT, V77, P1093, DOI 10.1001/jamapsychiatry.2020.1060
   Rubin CD., 2020, 6 WAYS SUPPORT SENIO
   Santini ZI, 2020, LANCET PUBLIC HEALTH, V5, pE62, DOI 10.1016/S2468-2667(19)30230-0
   Scott SB, 2011, PSYCHOL AGING, V26, P830, DOI 10.1037/a0023180
   Seegert L, 2020, OLDER AM ACT REAUTHO
   Seritan A, 2020, MAINTAINING WELLNESS
   Steinman MA, 2020, JAMA INTERN MED, V180, P819, DOI 10.1001/jamainternmed.2020.1661
   Stokol SE, 2021, LOS ANGELES TIMES
   Tucker-Seeley RD, 2009, ANN EPIDEMIOL, V19, P850, DOI 10.1016/j.annepidem.2009.08.003
   Vahia IV, 2020, JAMA-J AM MED ASSOC, V324, P2253, DOI 10.1001/jama.2020.21753
   Vahia IV, 2020, AM J GERIAT PSYCHIAT, V28, P695, DOI 10.1016/j.jagp.2020.03.007
   van den Berg N, 2012, MATURITAS, V73, P94, DOI 10.1016/j.maturitas.2012.06.010
   Van Orden KA, 2021, AM J GERIAT PSYCHIAT, V29, P816, DOI 10.1016/j.jagp.2020.05.004
   van Tilburg TG, 2021, J GERONTOL B-PSYCHOL, V76, pE249, DOI 10.1093/geronb/gbaa111
   Vazquez J, 2020, WELLNESS PROJECT SER
   Veazie S., 2019, ADDRESSING SOCIAL IS
   WASSERMAN IM, 1992, SUICIDE LIFE-THREAT, V22, P240
   Wootton R, 2012, J TELEMED TELECARE, V18, P211, DOI 10.1258/jtt.2012.120219
   Xiong JQ, 2020, J AFFECT DISORDERS, V277, P55, DOI 10.1016/j.jad.2020.08.001
   Yao H, 2020, LANCET PSYCHIAT, V7, pE21, DOI 10.1016/S2215-0366(20)30090-0
   Yeung DYL, 2007, AGING MENT HEALTH, V11, P579, DOI 10.1080/13607860601086355
   Yip PSF, 2010, CRISIS, V31, P86, DOI 10.1027/0227-5910/a000015
NR 80
TC 8
Z9 8
U1 2
U2 20
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1064-7481
EI 1545-7214
J9 AM J GERIAT PSYCHIAT
JI Am. J. Geriatr. Psychiatr.
PD NOV
PY 2021
VL 29
IS 11
BP 1101
EP 1116
DI 10.1016/j.jagp.2021.05.026
EA OCT 2021
PG 16
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA WF9TE
UT WOS:000706642400006
PM 34266752
OA Green Published
DA 2025-06-11
ER

PT J
AU Gunes, AO
   Caglayan, RHB
   Sen Demirogen, E
   Kose, S
   Ergingoz, E
   Ercan, O
   Alikasifoglu, M
AF Gunes, Asli Okbay
   Caglayan, Rahime Hulya Bingol
   Sen Demirogen, Ezgi
   Kose, Selmin
   Ergingoz, Ethem
   Ercan, Oya
   Alikasifoglu, Mujgan
TI Association Between Depression and Cardiometabolic Risk Factors in
   Adolescents with Obesity
SO MEDICAL JOURNAL OF BAKIRKOY
LA English
DT Article; Proceedings Paper
CT 9th Europaediatrics Congress
CY 2019
CL Dublin, IRELAND
DE Adolescents; cardiometabolic risk factors; degree of obesity; depression
ID OVERWEIGHT; CHILDHOOD; DISORDER; CHILDREN; DISEASE; INDEX
AB Objective: The aim of this study was to examine whether the presence of depression in overweight or obese adolescents increases the likelihood of cardiometabolic risk factors.
   Method: We performed a retrospective cross-sectional analysis of the data obtained from overweight or obese, adolescents aged 11-18 years, who were evaluated in our clinic from January 2012 to December 2015. Depression was evaluated by "Children's Depression Inventory". Hypertension, dyslipidemia, hyperinsulinemia, hyperglycemia and insulin resistance were defined as cardiometabolic risk factors. The degree of obesity was calculated as the body mass index standard deviation score.
   Results: Among 283 adolescents who were included in the study, 75 (26.5%) were overweight, and 208 (73.5%) were obese. The mean age was 14.02 +/- 1.67 years and 168 (59.4%) subjects were girls. The mean body mass index standard deviation score was 2.36 +/- 0.62, The mean Children's Depression Inventory score was 12.72 +/- 6.5, and 47 (16.6%) of the participants were in depression. Depression was more frequently detected in females than in males (p=0.047). Body mass index standard deviation score was in positive correlation with Children's Depression Inventory scores (r=0.123, p= 0.038). In univariate analyses, hyperinsulinemia was found to be 2.3 times more frequent in depressed group than in nondepressed group (p=0.026). In logistic regression analysis this relation disappeared.
   Conclusion: We showed that severity of depression increased, as the degree of obesity increased, but we could not find any clear relationship between depression and cardiometabolic risk factors in overweight or obese adolescents.
C1 [Gunes, Asli Okbay] Istanbul Univ, Cerrahpasa Med Fac, Dept Pediat, Istanbul, Turkey.
   [Caglayan, Rahime Hulya Bingol; Sen Demirogen, Ezgi] Istanbul Univ, Cerrahpasa Med Fac, Dept Child & Adolescent Psychiat, Istanbul, Turkey.
   [Kose, Selmin] Istanbul Bilim Univ, Dept Midwifery, Istanbul, Turkey.
   [Ergingoz, Ethem] Istanbul Univ, Cerrahpasa Med Fac, Dept Publ Hlth, Istanbul, Turkey.
   [Ercan, Oya] Istanbul Univ, Cerrahpasa Med Fac, Dept Pediat, Div Adolescent Med & Endocrinol, Istanbul, Turkey.
   [Alikasifoglu, Mujgan] Istanbul Univ, Cerrahpasa Med Fac, Dept Pediat, Div Adolescent Med, Istanbul, Turkey.
C3 Istanbul University - Cerrahpasa; Istanbul University; Istanbul
   University - Cerrahpasa; Istanbul University; Demiroglu Bilim
   University; Istanbul University; Istanbul University - Cerrahpasa;
   Istanbul University; Istanbul University - Cerrahpasa; Istanbul
   University - Cerrahpasa; Istanbul University
RP Alikasifoglu, M (corresponding author), Istanbul Univ, Cerrahpasa Med Fac, Dept Pediat, Div Adolescent Med, Istanbul, Turkey.
EM kasif@istanbul.edu.tr
RI ERCAN, OYA/IUP-6356-2023; Okbay Güneş, Aslı/ABH-3208-2021; Okbay Gunes,
   Asli/GRF-3734-2022; BINGOL CAGLAYAN, R.HULYA/AAB-1761-2020
OI BINGOL CAGLAYAN, R.HULYA/0000-0002-9414-7147
CR Bundak R, 2013, COCUK ENDOKRINOLOJIS, P21
   Carney RM, 2002, J PSYCHOSOM RES, V53, P897, DOI 10.1016/S0022-3999(02)00311-2
   Celik E, 2013, TURK PEDIAT ARS, V48, P103
   Cole TJ, 2000, BMJ-BRIT MED J, V320, P1240, DOI 10.1136/bmj.320.7244.1240
   Eidsdottir ST, 2014, EUR J PUBLIC HEALTH, V24, P888, DOI 10.1093/eurpub/ckt180
   Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents, 2011, Pediatrics, V128 Suppl 5, pS213, DOI 10.1542/peds.2009-2107C
   Flynn JT, 2017, PEDIATRICS, V140, DOI [10.1542/peds.2017-3035, 10.1542/peds.2017-1904]
   Fox CK, 2016, CLIN PEDIATR, V55, P1120, DOI 10.1177/0009922815615825
   Frasure-Smith N, 2009, BRAIN BEHAV IMMUN, V23, P1140, DOI 10.1016/j.bbi.2009.07.005
   Gelaye B, 2015, DIABETES METAB SYND, V9, P183, DOI 10.1016/j.dsx.2014.05.003
   Goldstein BI, 2015, CIRCULATION, V132, P965, DOI 10.1161/CIR.0000000000000229
   Gross AC, 2018, J PEDIATR-US, V199, P85, DOI 10.1016/j.jpeds.2018.03.059
   Günes AO, 2019, TURK PEDIATR ARSIVI, V54, P256, DOI 10.14744/TurkPediatriArs.2019.98372
   Günes AO, 2017, J CLIN RES PEDIATR E, V9, P237, DOI 10.4274/jcrpe.3794
   Huffman Jeff C, 2013, Cardiovasc Psychiatry Neurol, V2013, P695925, DOI 10.1155/2013/695925
   Keskin M, 2005, PEDIATRICS, V115, pE500, DOI 10.1542/peds.2004-1921
   Korczak DJ, 2013, DEV MED CHILD NEUROL, V55, P980, DOI 10.1111/dmcn.12168
   Köse S, 2021, INT J NURS PRACT, V27, DOI 10.1111/ijn.12878
   Kurtoglu Selim, 2010, J Clin Res Pediatr Endocrinol, V2, P100, DOI 10.4274/jcrpe.v2i3.100
   Lazarevich I, 2016, APPETITE, V107, P639, DOI 10.1016/j.appet.2016.09.011
   Mannan M, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0157240
   Milaneschi Y, 2019, MOL PSYCHIATR, V24, P18, DOI 10.1038/s41380-018-0017-5
   Miller GE, 2012, BIOL PSYCHIAT, V72, P34, DOI 10.1016/j.biopsych.2012.02.034
   Mühlig Y, 2016, OBES REV, V17, P235, DOI 10.1111/obr.12357
   Neyzi O, 2015, J CLIN RES PEDIATR E, V7, P280, DOI 10.4274/jcrpe.2183
   Oy B., 1991, Turk Psikiyatri Dergisi, V2, P132, DOI DOI 10.1016/J.BIOPSYCH.2017.12.014
   Palta P, 2014, PSYCHOSOM MED, V76, P12, DOI 10.1097/PSY.0000000000000009
   Reinehr T, 2005, NUTR METAB CARDIOVAS, V15, P181, DOI 10.1016/j.numecd.2004.06.003
   Slyper AH, 2006, CLIN ENDOCRINOL, V65, P1, DOI 10.1111/j.1365-2265.2006.02539.x
   Sönmez HE, 2019, CHILD OBES, V15, P468, DOI 10.1089/chi.2019.0022
   Sutaria S, 2019, ARCH DIS CHILD, V104, P64, DOI 10.1136/archdischild-2017-314608
   Wang SM, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16030340
   World Health Organization (WHO), Obesity and overweight
NR 33
TC 1
Z9 1
U1 0
U2 7
PU GALENOS YAYINCILIK
PI FINDIKZADE
PA MOLLA GURANI MAHALLESI KACAMAK SOKAK NO 21, FINDIKZADE, ISTANBUL 34093,
   TURKEY
SN 1305-9319
EI 1305-9327
J9 MED J BAKIRKOY
JI Med. J. Bakirkoy
PY 2020
VL 16
IS 4
BP 385
EP 391
DI 10.5222/BMJ.2020.74946
PG 7
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA PU1JK
UT WOS:000609064300013
OA gold
DA 2025-06-11
ER

PT J
AU Dharni, A
   Coates, D
AF Dharni, Aprajita
   Coates, Dominiek
TI Psychotropic medication profile in a community youth mental health
   service in Australia
SO CHILDREN AND YOUTH SERVICES REVIEW
LA English
DT Article
DE Psychotropic medication; Adolescent mental health; Prescribing patterns;
   Antidepressants; Antipsychotics
ID NATIONAL TRENDS; METABOLIC SYNDROME; ANTIPSYCHOTIC USE; CHILDREN;
   ADOLESCENTS; PREVALENCE; EFFICACY; ANTIDEPRESSANTS; DEPRESSION;
   QUETIAPINE
AB Aim: There has been a rise in the use of psychotropic medication in young people, despite limited risk-benefit profile of psychotropic medication for this population. Given their side effect profile, the use of psychotropic medications should occur with caution. This study investigated psychotropic prescribing pattern in a public youth community mental health service and gives an estimate of general level of psychotropic medication use in this setting.
   Methods: A retrospective file review was undertaken of all young people aged 12-17 who received care from the service in 2016 (N = 189) for a range of mental health problems, excluding psychosis. Files were reviewed for demographical information (age, gender), diagnosis/presenting issues, prescribed medications, indications of medications, and prescriber type (e.g. psychiatrist, general practitioners (GPs), paediatrician). The data was analysed descriptively.
   Results: Over 60% (60.8%, n = 115) of young people were prescribed psychotropic medications. Over half of the entire sample were on antidepressants (51.32%, n = 97), nearly a quarter (n = 46, 24%) on antipsychotics, 6% on ADHD medications (6.35%, n = 12), and a fifth (19.58%, n = 37) on polypharmacy. Antidepressants and antipsychotics were mostly used off-label, prescribed by public psychiatric staff. Quetiapine was the most prescribed antipsychotic predominantly for insomnia. Fluoxetine and fluvoxamine were the most prescribed antidepressants predominantly for anxiety disorders. Girls are more likely to be prescribed psychotropic medications than boys, specifically antipsychotic medication.
   Conclusions: A high proportion of young people were prescribed psychotropic medication, including anti psychotic medication, mostly for the treatment of anxiety and depressive disorders. There is little evidence around how psychotropic medication is used in youth mental health settings, and this study contributes to this gap.
C1 [Dharni, Aprajita; Coates, Dominiek] Univ Technol, Fac Hlth, Sydney, NSW, Australia.
C3 University of Technology Sydney
RP Coates, D (corresponding author), Univ Technol Sydney, Level 11,Bldg 10,235 Jones St, Ultimo, NSW 2007, Australia.
EM Dharni.Aprajita@health.nsw.gov.au; Dominiek.Coates@uts.edu.au
OI Coates, Dominiek/0000-0002-4463-7615
CR [Anonymous], 2012, A Guide for Community Child Serving Agencies on Psychotropic Medications for Children and Adolescents
   [Anonymous], 2014, Ethical considerations in quality assurance and evaluation activities
   [Anonymous], GL2007020 NSW HLTH
   [Anonymous], 2005, NICE GUID
   [Anonymous], 2015, National statement on ethical conduct in human research
   Brenner SL, 2014, J CHILD FAM STUD, V23, P666, DOI 10.1007/s10826-013-9882-3
   Brett J, 2017, AUST NZ J PSYCHIAT, V51, P990, DOI 10.1177/0004867417721018
   Brett J, 2015, AUST PRESCR, V38, P95, DOI 10.18773/austprescr.2015.032
   Carandang Carlo, 2011, J Can Acad Child Adolesc Psychiatry, V20, P315
   Cates ME, 2009, COMMUNITY MENT HLT J, V45, P251, DOI 10.1007/s10597-009-9200-0
   Chirdkiatgumchai V, 2013, PEDIATRICS, V132, P615, DOI 10.1542/peds.2013-1546
   Coates D, 2018, INT J MENT HEALTH NU, V27, P303, DOI 10.1111/inm.12321
   Correll CU, 2006, J AM ACAD CHILD PSY, V45, P771, DOI 10.1097/01.chi.0000220851.94392.30
   De Hert M, 2011, EUR PSYCHIAT, V26, P144, DOI 10.1016/j.eurpsy.2010.09.011
   Hert M, 2012, NAT REV ENDOCRINOL, V8, P114, DOI 10.1038/nrendo.2011.156
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   Gearing RE, 2006, J CAN ACAD CHILD ADO, V15, P126
   Gentile S, 2014, EXPERT OPIN DRUG SAF, V13, P735, DOI 10.1517/14740338.2014.908849
   Goddard AW, 2016, PSYCHIAT SERV, V67, P1030, DOI 10.1176/appi.ps.201500061
   Goldsmith L, 2011, CURR DRUG SAF, V6, P115, DOI 10.2174/157488611795684622
   Hálfdánarson O, 2017, EUR NEUROPSYCHOPHARM, V27, P1064, DOI 10.1016/j.euroneuro.2017.07.001
   Henry A, 2012, MOL PSYCHIATR, V17, P1186, DOI 10.1038/mp.2011.150
   Hetrick S, 2008, AUSTRALAS PSYCHIATRY, V16, P354, DOI 10.1080/10398560802189888
   Hetrick SE, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004851.pub3
   Hieber R., 2013, MENT HLTH CLIN, V2, P344
   Ilyas S, 2012, BRIT J PSYCHIAT, V200, P393, DOI 10.1192/bjp.bp.111.104257
   James A. C., 2010, ADV PSYCHIAT TREAT, V16, P63
   John AP, 2009, MED J AUSTRALIA, V190, P176, DOI 10.5694/j.1326-5377.2009.tb02342.x
   Jureidini JN, 2004, BMJ-BRIT MED J, V328, P879, DOI 10.1136/bmj.328.7444.879
   Kalverdijk LJ, 2017, CHILD ADOL PSYCH MEN, V11, DOI 10.1186/s13034-017-0192-1
   Karanges EA, 2014, AUST NZ J PSYCHIAT, V48, P917, DOI 10.1177/0004867414538675
   Kloosterboer SM, 2018, J CHILD ADOL PSYCHOP, V28, P173, DOI 10.1089/cap.2017.0155
   Lawrence D., 2015, MENTAL HLTH CHILDREN
   Lê Cook B, 2017, GEN HOSP PSYCHIAT, V45, P32, DOI 10.1016/j.genhosppsych.2016.12.004
   Leslie LK, 2011, CHILD ABUSE NEGLECT, V35, P333, DOI 10.1016/j.chiabu.2011.01.012
   Levin R, 2016, VALUE HEALTH, V19, pA522, DOI 10.1016/j.jval.2016.09.1020
   Mission Australia, 2017, YOUTH MENT HLTH REP
   Mojtabai R, 2016, PEDIATRICS, V138, DOI 10.1542/peds.2016-1878
   Olfson M, 2014, JAMA PSYCHIAT, V71, P81, DOI 10.1001/jamapsychiatry.2013.3074
   Olfson M, 2012, ARCH GEN PSYCHIAT, V69, P1247, DOI 10.1001/archgenpsychiatry.2012.647
   Owens JA, 2009, CHILD ADOL PSYCH CL, V18, P1001, DOI 10.1016/j.chc.2009.04.009
   Raghavan R, 2010, CHILD MALTREATMENT, V15, P121, DOI 10.1177/1077559509360916
   RANZCP, 2015, PROF PRACT GUID GUID
   RANZCP, 2005, CLIN GUID US ANT MED
   Read J, 2014, PSYCHIAT RES, V216, P67, DOI 10.1016/j.psychres.2014.01.042
   Schneider C, 2014, J PSYCHOPHARMACOL, V28, P615, DOI 10.1177/0269881114533599
   Sohn M, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000003784
   Stephenson CP, 2013, AUST NZ J PSYCHIAT, V47, P74, DOI 10.1177/0004867412466595
   Strawn JR, 2012, CHILD ADOL PSYCH CL, V21, P527, DOI 10.1016/j.chc.2012.05.003
   Thomas R., 2013, BRIT MED J, V347
   Topliss D, 2004, USE SSRI ANTIDEPRESS
   Tsapakis EM, 2008, BRIT J PSYCHIAT, V193, P10, DOI 10.1192/bjp.bp.106.031088
   UK National Health Service, 2016, AD PSYCH MORB SURV S
   Waterreus AJ, 2009, MED J AUSTRALIA, V190, P185, DOI 10.5694/j.1326-5377.2009.tb02344.x
   Wijlaars LPMM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033181
   Williams SG, 2010, PHARMACOTHERAPY, V30, P1011, DOI 10.1592/phco.30.10.1011
   Worster A, 2004, ACAD EMERG MED, V11, P187, DOI 10.1197/j.aem.2003.03.002
   Zito JM, 2013, PSYCHIAT SERV, V64, P223, DOI 10.1176/appi.ps.201200081
   Zuvekas SH, 2012, AM J PSYCHIAT, V169, P160, DOI 10.1176/appi.ajp.2011.11030387
NR 59
TC 5
Z9 5
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0190-7409
EI 1873-7765
J9 CHILD YOUTH SERV REV
JI Child. Youth Serv. Rev.
PD JUL
PY 2018
VL 90
BP 8
EP 14
DI 10.1016/j.childyouth.2018.05.007
PG 7
WC Family Studies; Social Work
WE Social Science Citation Index (SSCI)
SC Family Studies; Social Work
GA GL7GR
UT WOS:000437366100002
DA 2025-06-11
ER

PT J
AU Mattoo, SK
   Singh, SM
AF Mattoo, Surendra K.
   Singh, Shubh Mohan
TI Prevalence of metabolic syndrome in psychiatric inpatients in a tertiary
   care centre in north India
SO INDIAN JOURNAL OF MEDICAL RESEARCH
LA English
DT Article
DE Epidemiology; mental illness; metabolic syndrome; prevalence;
   psychiatric inpatients
ID 3RD NATIONAL-HEALTH; HEART-DISEASE RISK; INSULIN-RESISTANCE; OBESITY;
   SCHIZOPHRENIA; OVERWEIGHT; DEPRESSION; ADULTS
AB Background & objectives: Metabolic syndrome (MS) is associated with major mental illnesses. It is a major predictor of mortality and morbidity. This research was undertaken to study the prevalence and correlates of MS in psychiatric inpatients in a tertiary care hospital in north India.
   Methods: Consecutive adult patients with a primary psychiatric disorder admitted to the psychiatric ward during the study period (July-December 2007) were evaluated for prevalence of MS as per the criteria of the International Diabetes Federation (IDF).
   Results: Among the 90 patients included in the study, the prevalence of MS as per IDF was 37.8 per cent and it was significantly associated with the body mass index (BMI).
   Interpretation & conclusions: The present findings showed a higher prevalence of MS in psychiatric inpatients than that in the general population. Further studies on a larger sample need to be done before advising evaluation for the presence of MS in all psychiatric patients.
C1 [Mattoo, Surendra K.] Postgrad Inst Med Educ & Res, Dept Psychiat, Deaddict Ctr, Chandigarh 160012, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh
RP Mattoo, SK (corresponding author), Postgrad Inst Med Educ & Res, Dept Psychiat, Deaddict Ctr, Chandigarh 160012, India.
EM skm_ddtc@glide.net.in
OI Singh, Shubh Mohan/0000-0001-8533-6600
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   [Anonymous], 1992, INT CLASS DIS
   [Anonymous], EQUAL OPPORTUNITIES
   Bermudes RA, 2006, PSYCHOSOMATICS, V47, P491, DOI 10.1176/appi.psy.47.6.491
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   Cameron AJ, 2004, ENDOCRIN METAB CLIN, V33, P351, DOI 10.1016/j.ecl.2004.03.005
   Chambers JC, 2001, CIRCULATION, V104, P145, DOI 10.1161/01.CIR.104.2.145
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cohn T, 2004, CAN J PSYCHIAT, V49, P753, DOI 10.1177/070674370404901106
   Cornier MA, 2008, ENDOCR REV, V29, P777, DOI 10.1210/er.2008-0024
   Deepa M, 2007, DIABETES-METAB RES, V23, P127, DOI 10.1002/dmrr.658
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Elmslie JL, 2000, J CLIN PSYCHIAT, V61, P179, DOI 10.4088/JCP.v61n0306
   Elmslie JL, 2001, J CLIN PSYCHIAT, V62, P486, DOI 10.4088/JCP.v62n0614
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Garcia-Portilla MP, 2008, J AFFECT DISORDERS, V106, P197, DOI 10.1016/j.jad.2007.06.002
   Gavin JR, 1997, DIABETES CARE, V20, P1183
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Gupta A, 2003, DIABETES RES CLIN PR, V61, P69, DOI 10.1016/S0168-8227(03)00085-8
   Gupta R, 2004, INT J CARDIOL, V97, P257, DOI 10.1016/j.ijcard.2003.11.003
   Heiskanen T, 2003, J CLIN PSYCHIAT, V64, P575, DOI 10.4088/JCP.v64n0513
   Hu G, 2004, ARCH INTERN MED, V164, P1066, DOI 10.1001/archinte.164.10.1066
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   McElroy SL, 2002, J CLIN PSYCHIAT, V63, P207, DOI 10.4088/JCP.v63n0306
   McEvoy JP, 2005, SCHIZOPHR RES, V80, P19, DOI 10.1016/j.schres.2005.07.014
   Teixeira PJR, 2007, REV BRAS PSIQUIATR, V29, P330, DOI 10.1590/S1516-44462007000400007
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Tirupati S, 2007, AUSTRALAS PSYCHIATRY, V15, P470, DOI 10.1080/10398560701636906
NR 28
TC 20
Z9 24
U1 0
U2 5
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0971-5916
J9 INDIAN J MED RES
JI Indian J. Med. Res.
PD JAN
PY 2010
VL 131
IS 1
BP 46
EP 52
PG 7
WC Immunology; Medicine, General & Internal; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; General & Internal Medicine; Research & Experimental
   Medicine
GA 557XV
UT WOS:000274704600008
PM 20167973
DA 2025-06-11
ER

PT J
AU Noce, A
   Di Lauro, M
   Di Daniele, F
   Zaitseva, AP
   Marrone, G
   Borboni, P
   Di Daniele, N
AF Noce, Annalisa
   Di Lauro, Manuela
   Di Daniele, Francesca
   Zaitseva, Anna Pietroboni
   Marrone, Giulia
   Borboni, Patrizia
   Di Daniele, Nicola
TI Natural Bioactive Compounds Useful in Clinical Management of Metabolic
   Syndrome
SO NUTRIENTS
LA English
DT Review
DE metabolic syndrome; natural bioactive compounds; arterial hypertension;
   diabetes mellitus; dyslipidemia; low-grade inflammatory state;
   functional foods
ID RED YEAST RICE; CARDIOMETABOLIC RISK-FACTORS; DOSE-RESPONSE
   METAANALYSIS; RANDOMIZED DOUBLE-BLIND; ESTER TRANSFER PROTEIN; GREEN
   TEA; ADIPOSE-TISSUE; OXIDATIVE STRESS; BLOOD-PRESSURE; GUT MICROBIOTA
AB Metabolic syndrome (MetS) is a clinical manifestation characterized by a plethora of comorbidities, including hyperglycemia, abdominal obesity, arterial hypertension, and dyslipidemia. All MetS comorbidities participate to induce a low-grade inflammation state and oxidative stress, typical of this syndrome. MetS is related to an increased risk of cardiovascular diseases and early death, with an important impact on health-care costs. For its clinic management a poly-pharmaceutical therapy is often required, but this can cause side effects and reduce the patient's compliance. For this reason, finding a valid and alternative therapeutic strategy, natural and free of side effects, could represent a useful tool in the fight the MetS. In this context, the use of functional foods, and the assumption of natural bioactive compounds (NBCs), could exert beneficial effects on body weight, blood pressure and glucose metabolism control, on endothelial damage, on the improvement of lipid profile, on the inflammatory state, and on oxidative stress. This review focuses on the possible beneficial role of NBCs in the prevention and in the clinical management of MetS and its comorbidities.
C1 [Noce, Annalisa; Di Lauro, Manuela; Di Daniele, Francesca; Zaitseva, Anna Pietroboni; Marrone, Giulia; Di Daniele, Nicola] Univ Roma Tor Vergata, UOC Internal Med, Dept Syst Med, Ctr Hypertens, Via Montpellier 1, I-00133 Rome, Italy.
   [Noce, Annalisa; Di Lauro, Manuela; Di Daniele, Francesca; Zaitseva, Anna Pietroboni; Marrone, Giulia; Di Daniele, Nicola] Univ Roma Tor Vergata, Dept Syst Med, Nephrol Unit, Via Montpellier 1, I-00133 Rome, Italy.
   [Di Daniele, Francesca; Marrone, Giulia] Univ Roma Tor Vergata, PhD Sch Appl Med, Surg Sci, Via Montpellier 1, I-00133 Rome, Italy.
   [Borboni, Patrizia] Univ Roma Tor Vergata, Dept Syst Med, Via Montpellier 1, I-00133 Rome, Italy.
C3 University of Rome Tor Vergata; University of Rome Tor Vergata;
   University of Rome Tor Vergata; University of Rome Tor Vergata
RP Noce, A; Marrone, G (corresponding author), Univ Roma Tor Vergata, UOC Internal Med, Dept Syst Med, Ctr Hypertens, Via Montpellier 1, I-00133 Rome, Italy.; Noce, A; Marrone, G (corresponding author), Univ Roma Tor Vergata, Dept Syst Med, Nephrol Unit, Via Montpellier 1, I-00133 Rome, Italy.; Marrone, G (corresponding author), Univ Roma Tor Vergata, PhD Sch Appl Med, Surg Sci, Via Montpellier 1, I-00133 Rome, Italy.
EM annalisa.noce@uniroma2.it; dilauromanuela@gmail.com;
   francesca.didaniele@gmail.com; annapietroboni@icloud.com;
   giul.marr@gmail.com; patrizia.borboni@alice.it;
   didaniele@med.uniroma2.it
RI Noce, Annalisa/B-5558-2019; Di Lauro, Manuela/AAB-9784-2022; Marrone,
   Giulia/IQR-7760-2023
OI Pietroboni Zaitseva, Anna/0000-0001-5407-322X; Marrone,
   Giulia/0000-0002-5854-2086; NOCE, ANNALISA/0000-0003-1310-3730; Di
   Lauro, Manuela/0000-0001-8118-1330
CR Adibian M, 2019, PHYTOTHER RES, V33, P1374, DOI 10.1002/ptr.6328
   Ahn J, 2008, BIOCHEM BIOPH RES CO, V373, P545, DOI 10.1016/j.bbrc.2008.06.077
   Akbari M, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-1198-x
   Akbari M, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.00649
   Akilen R, 2013, NUTRITION, V29, P1192, DOI 10.1016/j.nut.2013.03.007
   Al Disi SS, 2016, FRONT PHARMACOL, V6, DOI 10.3389/fphar.2015.00323
   Alasalvar C, 2003, J AGR FOOD CHEM, V51, P3790, DOI 10.1021/jf0212385
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Alemán-Jiménez C, 2021, EUR J NUTR, V60, P905, DOI 10.1007/s00394-020-02295-0
   Alexopoulos N, 2014, ATHEROSCLEROSIS, V233, P104, DOI 10.1016/j.atherosclerosis.2013.12.023
   Ali F, 2014, MOL NUTR FOOD RES, V58, P33, DOI 10.1002/mnfr.201300277
   Alkhatib A, 2017, NUTRIENTS, V9, DOI 10.3390/nu9121310
   Alvarez-Collazo J, 2014, PFLUG ARCH EUR J PHY, V466, P2089, DOI 10.1007/s00424-014-1472-8
   Anderson RA, 2004, J AGR FOOD CHEM, V52, P65, DOI 10.1021/jf034916b
   Andrade S, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20092313
   Fernández VA, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9050440
   Annalisa N, 2014, MEDIAT INFLAMM, V2014, DOI 10.1155/2014/901308
   Appeldoorn MM, 2009, J NUTR, V139, P1469, DOI 10.3945/jn.109.106765
   Arauna D, 2019, MOLECULES, V24, DOI 10.3390/molecules24234259
   Arnaud Maurice J, 2011, Handb Exp Pharmacol, P33, DOI 10.1007/978-3-642-13443-2_3
   Arreola R, 2015, J IMMUNOL RES, V2015, DOI 10.1155/2015/401630
   Arumugam M, 2011, NATURE, V473, P174, DOI 10.1038/nature09944
   Askari G, 2012, J RES MED SCI, V17, P637
   Bagetta D, 2020, EUR J MED CHEM, V186, DOI 10.1016/j.ejmech.2019.111903
   Bai XF, 2018, MINI-REV MED CHEM, V18, P1151, DOI 10.2174/1389557516666160620095103
   Barnard SA, 2016, BLOOD REV, V30, P421, DOI 10.1016/j.blre.2016.05.002
   Basu A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11091983
   Bayram B, 2012, REJUV RES, V15, P71, DOI 10.1089/rej.2011.1245
   Becker DJ, 2009, ANN INTERN MED, V150, P830, DOI 10.7326/0003-4819-150-12-200906160-00006
   Beejmohun V, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-351
   Belcaro G, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/869061
   Bendinelli B, 2011, AM J CLIN NUTR, V93, P275, DOI 10.3945/ajcn.110.000521
   Bhupathiraju SN, 2013, AM J CLIN NUTR, V97, P155, DOI 10.3945/ajcn.112.048603
   Blüher M, 2016, CLIN SCI, V130, P1603, DOI 10.1042/CS20160005
   Botta M, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19041197
   Boudreau DM, 2009, METAB SYNDR RELAT D, V7, P305, DOI 10.1089/met.2008.0070
   Breuss JM, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20071523
   Calvano A, 2019, FOOD FUNCT, V10, P6227, DOI [10.1039/C9FO01426H, 10.1039/c9fo01426h]
   Cao HP, 2007, ARCH BIOCHEM BIOPHYS, V459, P214, DOI 10.1016/j.abb.2006.12.034
   Capomolla AS, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061271
   Carlsen I, 2015, AM J PHYSIOL-RENAL, V308, pF1297, DOI 10.1152/ajprenal.00514.2014
   Carpi S, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122855
   Cassady BA, 2009, AM J CLIN NUTR, V89, P794, DOI 10.3945/ajcn.2008.26669
   Castro-Barquero S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12102983
   Chan SW, 2020, MOLECULES, V25, DOI 10.3390/molecules25071653
   Chaplin A, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111651
   Chen CH, 2013, INT J PHARMACEUT, V444, P18, DOI 10.1016/j.ijpharm.2013.01.028
   Chen IJ, 2016, CLIN NUTR, V35, P592, DOI 10.1016/j.clnu.2015.05.003
   Choudhary Prema Ram, 2018, Journal of Dietary Supplements, V15, P499, DOI 10.1080/19390211.2017.1358233
   Chow HHS, 2001, CANCER EPIDEM BIOMAR, V10, P53
   Christensen KB, 2010, PHYTOTHER RES, V24, pS129, DOI 10.1002/ptr.3005
   Chuengsamarn S, 2012, DIABETES CARE, V35, P2121, DOI 10.2337/dc12-0116
   Cicero Arrigo F G, 2019, Methodist Debakey Cardiovasc J, V15, P192, DOI 10.14797/mdcj-15-3-192
   Cicero AFG, 2019, PHYTOTHER RES, V33, P2094, DOI 10.1002/ptr.6402
   Ciocoiu M, 2009, J PHYSIOL BIOCHEM, V65, P297, DOI 10.1007/BF03180582
   Clark KS, 2019, CLIN EXP PHARMACOL P, V46, P475, DOI 10.1111/1440-1681.13065
   Conlon MA, 2015, NUTRIENTS, V7, P17, DOI 10.3390/nu7010017
   Costello RB, 2016, J ACAD NUTR DIET, V116, P1794, DOI 10.1016/j.jand.2016.07.015
   Couto E, 2011, BRIT J CANCER, V104, P1493, DOI 10.1038/bjc.2011.106
   Crawford P, 2009, J AM BOARD FAM MED, V22, P507, DOI 10.3122/jabfm.2009.05.080093
   De Filippo C, 2010, P NATL ACAD SCI USA, V107, P14691, DOI 10.1073/pnas.1005963107
   De Pergola G, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111700
   Dei Cas M, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092147
   Dessì M, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-54
   Devaraj S, 2013, METAB SYNDR RELAT D, V11, P35, DOI 10.1089/met.2012.0066
   Di Daniele N, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010274
   Di Daniele N, 2017, ONCOTARGET, V8, P8947, DOI 10.18632/oncotarget.13553
   Di Lorenzo C, 2013, PLANT FOOD HUM NUTR, V68, P149, DOI 10.1007/s11130-013-0354-0
   Di Pierro F, 2015, EUR REV MED PHARMACO, V19, P4195
   Dick WR, 2016, J ALTERN COMPLEM MED, V22, P450, DOI 10.1089/acm.2015.0122
   Ding M, 2014, CIRCULATION, V129, P643, DOI 10.1161/CIRCULATIONAHA.113.005925
   Donath MY, 2011, NAT REV IMMUNOL, V11, P98, DOI 10.1038/nri2925
   Efentakis P, 2015, PLANTA MED, V81, P648, DOI 10.1055/s-0035-1546017
   El-Moselhy MA, 2011, FOOD CHEM TOXICOL, V49, P1129, DOI 10.1016/j.fct.2011.02.004
   Eldin IMT, 2010, ENVIRON HEALTH INSIG, V4, P71, DOI 10.4137/EHI.S5540
   Estruch R, 2018, NEW ENGL J MED, V378, DOI [10.1056/NEJMoa1800389, 10.1056/NEJMoa1200303, 10.1056/nejmoa1800389]
   Fang J, 2014, DRUG METAB REV, V46, P508, DOI 10.3109/03602532.2014.978080
   Almeida AF, 2018, COMPR REV FOOD SCI F, V17, P714, DOI 10.1111/1541-4337.12342
   Fogacci F, 2019, CRIT REV FOOD SCI, V59, P1605, DOI 10.1080/10408398.2017.1422480
   Forney LA, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19030895
   Frühbeck G, 2018, ADIPOCYTE, V7, P57, DOI 10.1080/21623945.2017.1402151
   Fuccelli R, 2018, MOLECULES, V23, DOI 10.3390/molecules23123212
   Gallù M, 2020, CARDIOVASC THER, V2020, DOI 10.1155/2020/1743927
   García-Villalba R, 2010, ANAL BIOANAL CHEM, V398, P463, DOI 10.1007/s00216-010-3899-x
   Ghorbani A, 2017, BIOMED PHARMACOTHER, V96, P305, DOI 10.1016/j.biopha.2017.10.001
   Gill PA, 2018, ALIMENT PHARM THER, V48, P15, DOI 10.1111/apt.14689
   Godsland IF, 2005, DIABETOLOGIA, V48, P2213, DOI 10.1007/s00125-005-1930-0
   Gombault A, 2013, FRONT IMMUNOL, V3, DOI 10.3389/fimmu.2012.00414
   Gomez-Arbelaez Diego, 2013, Mediators Inflamm, V2013, P285795, DOI 10.1155/2013/285795
   Gómez-Juaristi M, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071441
   Graefe EU, 2001, J CLIN PHARMACOL, V41, P492, DOI 10.1177/00912700122010366
   Grandl G, 2018, SEMIN IMMUNOPATHOL, V40, P215, DOI 10.1007/s00281-017-0666-5
   Grassi D, 2008, J NUTR, V138, P1671, DOI 10.1093/jn/138.9.1671
   Greer F, 2001, DIABETES, V50, P2349, DOI 10.2337/diabetes.50.10.2349
   Gutierres VO, 2012, BRIT J NUTR, V108, P440, DOI 10.1017/S0007114511005769
   Haghighatdoost F, 2018, NUTRITION, V45, P17, DOI 10.1016/j.nut.2017.06.022
   Haidari F, 2017, ASIA PAC J CLIN NUTR, V26, P1048, DOI 10.6133/apjcn.022017.03
   Hamed MS, 2008, SOUTH MED J, V101, P1203, DOI 10.1097/SMJ.0b013e31818859eb
   Han XZ, 2007, INT J MOL SCI, V8, P950, DOI 10.3390/i8090950
   Harpaz Eynav, 2017, Journal of Basic and Clinical Physiology and Pharmacology, V28, P1, DOI 10.1515/jbcpp-2016-0090
   Hasani H, 2019, PHYTOTHER RES, V33, P1639, DOI 10.1002/ptr.6362
   Helal A, 2014, J FUNCT FOODS, V7, P506, DOI 10.1016/j.jff.2014.01.005
   Hermansen K, 2003, ADV THER, V20, P50, DOI 10.1007/BF02850119
   Hernández-Alonso P, 2017, NUTRIENTS, V9, DOI 10.3390/nu9070673
   Hernández-Alonso P, 2017, EUR J NUTR, V56, P2181, DOI 10.1007/s00394-016-1262-5
   Hibi M, 2018, NUTR RES, V55, P1, DOI 10.1016/j.nutres.2018.03.012
   Hooper L, 2012, AM J CLIN NUTR, V95, P740, DOI 10.3945/ajcn.111.023457
   Hosseini S, 2014, J ETHNOPHARMACOL, V152, P451, DOI 10.1016/j.jep.2014.01.012
   Huang HH, 2016, OBES REV, V17, P1329, DOI 10.1111/obr.12458
   Huang J, 2014, EUR J CLIN NUTR, V68, P1075, DOI 10.1038/ejcn.2014.143
   Huang LH, 2018, BMC COMPLEM ALTERN M, V18, DOI 10.1186/s12906-018-2355-x
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Hursel R, 2011, OBES REV, V12, pE573, DOI 10.1111/j.1467-789X.2011.00862.x
   Hwang JT, 2009, NEW BIOTECHNOL, V26, P17, DOI 10.1016/j.nbt.2009.03.005
   Imamura H, 2017, MOL GENET METAB REP, V12, P44, DOI 10.1016/j.ymgmr.2017.05.003
   Jain SG, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0504-8
   Jarvill-Taylor KJ, 2001, J AM COLL NUTR, V20, P327, DOI 10.1080/07315724.2001.10719053
   Jia QL, 2019, INT J MOL MED, V44, P893, DOI 10.3892/ijmm.2019.4263
   Jumar A, 2016, J CLIN HYPERTENS, V18, P352, DOI 10.1111/jch.12715
   Kappel VD, 2013, J PHARM PHARMACOL, V65, P1179, DOI 10.1111/jphp.12066
   Kappel VD, 2013, ARCH BIOCHEM BIOPHYS, V532, P55, DOI 10.1016/j.abb.2013.01.008
   Karasawa MMG, 2018, NAT PRODUCT BIOPROSP, V8, P335, DOI 10.1007/s13659-018-0186-6
   Kawabata K, 2019, MOLECULES, V24, DOI 10.3390/molecules24020370
   Kay CD, 2006, NUTR RES REV, V19, P137, DOI 10.1079/NRR2005116
   Khan A, 2003, DIABETES CARE, V26, P3215, DOI 10.2337/diacare.26.12.3215
   Kinger M, 2018, MINI-REV MED CHEM, V18, P1270, DOI 10.2174/1389557517666170208143410
   Klein S, 2007, DIABETES CARE, V30, P1647, DOI 10.2337/dc07-9921
   Konstantinidi Melina, 2019, Medicines (Basel), V6, DOI 10.3390/medicines6030094
   Krishnan S, 2015, CURR OPIN BIOTECH, V36, P137, DOI 10.1016/j.copbio.2015.08.015
   Kwon MJ, 2003, LIFE SCI, V72, P2953, DOI 10.1016/S0024-3205(03)00234-0
   Landete JM, 2012, CRIT REV FOOD SCI, V52, P936, DOI 10.1080/10408398.2010.513779
   Lawson LD, 2018, NUTRIENTS, V10, DOI 10.3390/nu10070812
   Lear SA, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010015
   Lee A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061274
   Lee HC, 2006, RES MICROBIOL, V157, P876, DOI 10.1016/j.resmic.2006.07.004
   Leiherer A, 2016, NUTRIENTS, V8, DOI 10.3390/nu8050282
   Leyva-Soto A, 2018, MOLECULES, V23, DOI 10.3390/molecules23092220
   Li F, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01366
   Li H, 2019, J AGR FOOD CHEM, V67, P90, DOI 10.1021/acs.jafc.8b04527
   Li LL, 2019, MOLECULES, V24, DOI 10.3390/molecules24030512
   Li RZ, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8165707
   Li YQ, 2009, J AGR FOOD CHEM, V57, P11463, DOI 10.1021/jf903083h
   Li Y, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030167
   Li YH, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0098611
   Liu K, 2013, AM J CLIN NUTR, V98, P340, DOI 10.3945/ajcn.112.052746
   Liu LJ, 2002, J NUTR, V132, P1129, DOI 10.1093/jn/132.6.1129
   Liu RH, 2004, J NUTR, V134, p3479S, DOI 10.1093/jn/134.12.3479S
   Liu RH, 2013, J FOOD SCI, V78, pA18, DOI 10.1111/1750-3841.12101
   Liu RH, 2013, ADV NUTR, V4, p384S, DOI 10.3945/an.112.003517
   Liu T, 2017, SIGNAL TRANSDUCT TAR, V2, DOI 10.1038/sigtrans.2017.23
   López-Yerena A, 2020, PHARMACEUTICS, V12, DOI 10.3390/pharmaceutics12020134
   Lopeza S, 2016, CURR VASC PHARMACOL, V14, P323, DOI 10.2174/1570161114666160118105137
   Lorenzo C, 2007, DIABETES CARE, V30, P8, DOI 10.2337/dc06-1414
   Ludovici V, 2017, FRONT NUTR, V4, DOI 10.3389/fnut.2017.00036
   Ros JL, 2015, PLANTA MED, V81, P975, DOI 10.1055/s-0035-1546131
   Markovic AK, 2019, MOLECULES, V24, DOI 10.3390/molecules24102001
   Marrelli M, 2019, MOLECULES, V24, DOI 10.3390/molecules24010119
   Massaro M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061548
   Massaro M, 2010, CARDIOVASC THER, V28, pe13, DOI 10.1111/j.1755-5922.2010.00211.x
   Matsutomo T, 2020, EXP THER MED, V19, P1479, DOI 10.3892/etm.2019.8375
   Medagama AB, 2015, NUTR J, V14, DOI [10.1186/s12937-015-0013-4, 10.1186/s12937-015-0098-9]
   Mielgo-Ayuso J, 2014, BRIT J NUTR, V111, P1263, DOI 10.1017/S0007114513003784
   Milne JC, 2007, NATURE, V450, P712, DOI 10.1038/nature06261
   Mohamed EI, 2002, LUNG, V180, P149, DOI 10.1007/s004080000089
   Moldogazieva NT, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/3085756
   Mollace V, 2019, ENDOCR METAB IMMUNE, V19, P136, DOI 10.2174/1871530319666181203151513
   Mollace V, 2011, FITOTERAPIA, V82, P309, DOI 10.1016/j.fitote.2010.10.014
   Mollazadeh H, 2016, IRAN J BASIC MED SCI, V19, P1258, DOI 10.22038/ijbms.2016.7906
   Monagas M, 2009, BRIT J NUTR, V102, P201, DOI 10.1017/S0007114508162110
   Monteiro J, 2019, CRIT REV FOOD SCI, V59, P2597, DOI 10.1080/10408398.2018.1461607
   Monteiro JP, 2016, MOLECULES, V21, DOI 10.3390/molecules21080974
   Monteiro R, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/289645
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Mousavi SM, 2020, CRIT REV FOOD SCI, V60, P3144, DOI 10.1080/10408398.2019.1678012
   Mousavi SM, 2020, CRIT REV FOOD SCI, V60, P171, DOI 10.1080/10408398.2018.1517724
   Muhammad DRA, 2017, INT J FOOD PROP, V20, P2237, DOI 10.1080/10942912.2017.1369102
   Mukkavilli R, 2017, MOLECULES, V22, DOI 10.3390/molecules22040553
   Muley A, 2012, CURR DIABETES REV, V8, P162, DOI 10.2174/157339912800564016
   Mumford GK, 1996, EUR J CLIN PHARMACOL, V51, P319, DOI 10.1007/s002280050205
   Mursu J, 2004, FREE RADICAL BIO MED, V37, P1351, DOI 10.1016/j.freeradbiomed.2004.06.002
   Na LX, 2011, NUTR METAB CARDIOVAS, V21, P526, DOI 10.1016/j.numecd.2009.11.009
   Na LX, 2013, MOL NUTR FOOD RES, V57, P1569, DOI 10.1002/mnfr.201200131
   Nagao T, 2009, OBESITY, V17, P310, DOI 10.1038/oby.2008.505
   Neilson AP, 2010, J AGR FOOD CHEM, V58, P6685, DOI 10.1021/jf1005353
   Noce A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020591
   Noce A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020581
   Noce A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010147
   Noce A, 2020, NUTRIENTS, V12, DOI 10.3390/nu12092519
   Noce A, 2020, CARDIOVASC THER, V2020, DOI 10.1155/2020/1807941
   Noce A, 2020, PHARMACEUTICALS-BASE, V13, DOI 10.3390/ph13070148
   Noce A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11051073
   Noce A, 2015, AGING-US, V7, P269, DOI 10.18632/aging.100740
   Noce A, 2014, ACTA DIABETOL, V51, P219, DOI 10.1007/s00592-013-0497-3
   Olefsky JM, 2000, J CLIN INVEST, V106, P467, DOI 10.1172/JCI10843
   Ortuño J, 2010, FOOD CHEM, V120, P1123, DOI 10.1016/j.foodchem.2009.11.032
   Osim E., 2014, RES J PHARM BIOL CHE, V5, P647
   Oyenihi OR, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/9737483
   Öztürk E, 2017, BIOMED PHARMACOTHER, V95, P230, DOI 10.1016/j.biopha.2017.08.070
   Panahi Y, 2018, DRUG RES, V68, P403, DOI 10.1055/s-0044-101752
   Panahi Y, 2017, CURR CLIN PHARMACOL, V12, P253, DOI 10.2174/1574884713666180104095641
   Panahi Y, 2016, NUTRITION, V32, P1116, DOI 10.1016/j.nut.2016.03.018
   Parkinson L, 2016, MOLECULES, V21, DOI 10.3390/molecules21121734
   Patel S, 2016, WORLD J MICROB BIOT, V32, DOI 10.1007/s11274-016-2035-2
   Peters R, 2019, THER ADV CHRONIC DIS, V10, DOI 10.1177/2040622319880392
   Petersen B, 2016, FOOD RES INT, V88, P159, DOI 10.1016/j.foodres.2016.02.013
   Pivari F, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081837
   Price NL, 2012, CELL METAB, V15, P675, DOI 10.1016/j.cmet.2012.04.003
   Prysyazhna O, 2019, CIRCULATION, V140, P126, DOI 10.1161/CIRCULATIONAHA.118.037398
   Qin Y, 2009, AM J CLIN NUTR, V90, P485, DOI 10.3945/ajcn.2009.27814
   Rafehi H, 2012, DIABETES OBES METAB, V14, P493, DOI 10.1111/j.1463-1326.2011.01538.x
   Rai SK, 2009, LIFE SCI, V85, P211, DOI 10.1016/j.lfs.2009.05.020
   Rains TM, 2011, J NUTR BIOCHEM, V22, P1, DOI 10.1016/j.jnutbio.2010.06.006
   Raman G, 2019, AM J CLIN NUTR, V110, P1067, DOI 10.1093/ajcn/nqz178
   Ramdath DD, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040324
   Rastmanesh R, 2011, CHEM-BIOL INTERACT, V189, P1, DOI 10.1016/j.cbi.2010.10.002
   Reaven GM, 2006, AM J CLIN NUTR, V83, P1237, DOI 10.1093/ajcn/83.6.1237
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Ribeiro PVM, 2019, CRIT REV FOOD SCI, V59, P1115, DOI 10.1080/10408398.2017.1392290
   Riboli E, 2002, PUBLIC HEALTH NUTR, V5, P1113, DOI 10.1079/PHN2002394
   Ricketts ML, 2005, J NUTR BIOCHEM, V16, P321, DOI 10.1016/j.jnutbio.2004.11.008
   Ried K, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008893.pub3
   Rinninella E, 2019, MICROORGANISMS, V7, DOI 10.3390/microorganisms7010014
   Rivera L, 2008, OBESITY, V16, P2081, DOI 10.1038/oby.2008.315
   Robles-Almazan M, 2018, FOOD RES INT, V105, P654, DOI 10.1016/j.foodres.2017.11.053
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Rock CL, 2017, NUTR J, V16, DOI 10.1186/s12937-017-0304-z
   Romani A, 2020, MOLECULES, V25, DOI 10.3390/molecules25204757
   Romani A, 2020, FRONT NUTR, V7, DOI 10.3389/fnut.2020.00120
   Romani A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081776
   Rotches-Ribalta M, 2012, PHARMACOL RES, V66, P375, DOI 10.1016/j.phrs.2012.08.001
   Rozati M, 2015, NUTR METAB, V12, DOI 10.1186/s12986-015-0022-5
   Rufer CE, 2008, AM J CLIN NUTR, V87, P1314, DOI 10.1093/ajcn/87.5.1314
   Rusu ME, 2018, FOOD FUNCT, V9, P2554, DOI [10.1039/c7fo01967j, 10.1039/C7FO01967J]
   Saibandith B, 2017, MOLECULES, V22, DOI 10.3390/molecules22071082
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Saltiel AR, 2017, J CLIN INVEST, V127, P1, DOI [10.1172/JCI92035, 10.1172/jci92035]
   Sarriá B, 2020, PEERJ, V8, DOI 10.7717/peerj.9953
   Sarriá B, 2015, FOOD CHEM, V174, P214, DOI 10.1016/j.foodchem.2014.11.004
   Sato S, 2020, J INFLAMM RES, V13, P421, DOI 10.2147/JIR.S228361
   Scheja L, 2019, NAT REV ENDOCRINOL, V15, P507, DOI 10.1038/s41574-019-0230-6
   Schinzari F, 2015, AM J PHYSIOL-ENDOC M, V309, pE787, DOI 10.1152/ajpendo.00278.2015
   Schramm DD, 2003, LIFE SCI, V73, P857, DOI 10.1016/S0024-3205(03)00373-4
   Scotece M, 2012, LIFE SCI, V91, P1229, DOI 10.1016/j.lfs.2012.09.012
   Sedaghat A, 2019, DIAB MET SYND CLIN R, V13, P1387, DOI 10.1016/j.dsx.2019.01.057
   Shabani E, 2019, PRIM CARE DIABETES, V13, P28, DOI 10.1016/j.pcd.2018.07.007
   Shamim Shariq, 2013, Mo Med, V110, P349
   Sharma RA, 2001, CLIN CANCER RES, V7, P1894
   Sharma RA, 2007, ADV EXP MED BIOL, V595, P453
   Sharma UK, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1147-4
   Shayo SC, 2019, DIABETES METAB SYND, V13, P2164, DOI 10.1016/j.dsx.2019.05.005
   Sheng XY, 2008, PPAR RES, V2008, DOI 10.1155/2008/581348
   Shin Eunju, 2011, Immune Netw, V11, P107, DOI 10.4110/in.2011.11.2.107
   Simental-Mendía LE, 2019, NUTRITION, V58, P7, DOI 10.1016/j.nut.2018.06.015
   Sinagra E, 2014, PROG NUTR, V16, P79
   Singh AK, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092216
   Smirnov A, 2016, AGING-US, V8, P1384, DOI 10.18632/aging.100988
   Sobenin IA, 2008, ACTA DIABETOL, V45, P1, DOI 10.1007/s00592-007-0011-x
   Stabler SN, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007653.pub2
   Storniolo CE, 2017, EUR J NUTR, V56, P89, DOI 10.1007/s00394-015-1060-5
   Stull AJ, 2010, J NUTR, V140, P1764, DOI 10.3945/jn.110.125336
   Summerhill V, 2018, FRONT CARDIOVASC MED, V5, DOI 10.3389/fcvm.2018.00188
   Suzuki T, 2016, MOLECULES, V21, DOI 10.3390/molecules21101305
   Tabrizi R, 2019, CRIT REV FOOD SCI, V59, P2688, DOI 10.1080/10408398.2018.1507996
   Takikawa M, 2010, J NUTR, V140, P527, DOI 10.3945/jn.109.118216
   Taku K, 2007, AM J CLIN NUTR, V85, P1148, DOI 10.1093/ajcn/85.4.1148
   Tan SY, 2013, EUR J CLIN NUTR, V67, P1205, DOI 10.1038/ejcn.2013.184
   Tejero J, 2019, PHYSIOL REV, V99, P311, DOI 10.1152/physrev.00036.2017
   Tokede OA, 2011, EUR J CLIN NUTR, V65, P879, DOI 10.1038/ejcn.2011.64
   Toledo E, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-207
   Tomé-Carneiro J, 2013, PHARMACOL RES, V72, P69, DOI 10.1016/j.phrs.2013.03.011
   Tsuda T, 2016, ANTIOXIDANTS-BASEL, V5, DOI 10.3390/antiox5020013
   Tsuda T, 2015, MOL NUTR FOOD RES, V59, P1264, DOI 10.1002/mnfr.201400871
   Tune JD, 2017, TRANSL RES, V183, P57, DOI 10.1016/j.trsl.2017.01.001
   Um JH, 2010, DIABETES, V59, P554, DOI 10.2337/db09-0482
   Unno T, 2014, J NUTR SCI VITAMINOL, V60, P213, DOI 10.3177/jnsv.60.213
   Vamanu E, 2019, PHARMACEUTICS, V11, DOI 10.3390/pharmaceutics11040191
   Varghese JF, 2018, CURR CARDIOL REV, V14, P4, DOI 10.2174/1573403X13666171009112250
   Cisneros LCV, 2017, NUTR HOSP, V34, P731, DOI 10.20960/nh.753
   Vazquez-Prieto MA, 2011, J NUTR METAB, V2011, DOI 10.1155/2011/475216
   Wang J, 2017, ANN NY ACAD SCI, V1398, P83, DOI 10.1111/nyas.13375
   Wang J, 2015, NAT MED, V21, P820, DOI 10.1038/nm.3890
   Wang PX, 2020, CHINESE MED J-PEKING, V133, P808, DOI 10.1097/CM9.0000000000000696
   Watanabe S, 1998, J NUTR, V128, P1710, DOI 10.1093/jn/128.10.1710
   Watanabe T, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071617
   Weisberg SP, 2008, ENDOCRINOLOGY, V149, P3549, DOI 10.1210/en.2008-0262
   Wicinski M, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111813
   Wu LY, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102307
   Wu LY, 2004, EUR J NUTR, V43, P116, DOI 10.1007/s00394-004-0450-x
   Xiong XJ, 2015, PHYTOMEDICINE, V22, P352, DOI 10.1016/j.phymed.2014.12.013
   Xu D, 2019, MOLECULES, V24, DOI 10.3390/molecules24061123
   Xu RF, 2020, NUTR METAB, V17, DOI [10.1186/s12986-020-00469-5, 10.1186/s12986-020-00472-w]
   Yamagishi S, 2011, EXP GERONTOL, V46, P217, DOI 10.1016/j.exger.2010.11.007
   Yang CS, 2016, MOL NUTR FOOD RES, V60, P160, DOI 10.1002/mnfr.201500428
   Yang LP, 2017, NUTRIENTS, V9, DOI 10.3390/nu9101104
   Yang WS, 2014, BRIT J NUTR, V111, P1329, DOI 10.1017/S0007114513003887
   Zanzer YC, 2017, J FUNCT FOODS, V35, P574, DOI 10.1016/j.jff.2017.06.016
   Zhan SY, 2005, AM J CLIN NUTR, V81, P397
   Zhang XM, 2009, N-S ARCH PHARMACOL, V379, P581, DOI 10.1007/s00210-009-0399-7
   Zhang Y, 2018, INT J FOOD SCI NUTR, V69, P1003, DOI 10.1080/09637486.2018.1445202
   Zhang YB, 2013, NUTRITION, V29, P8, DOI 10.1016/j.nut.2012.03.019
   Zhao YS, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/1459497
   Zhong YC, 2020, CURR PHARM BIOTECHNO, V21, P1099, DOI 10.2174/1389201021666200318124922
   Zhu B, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.01449
   Zhu J, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/5692962
   Ziegenfuss TN, 2006, J INT SOC SPORT NUTR, V3, DOI 10.1186/1550-2783-3-2-45
   Zimmet P, 2005, J ATHEROSCLER THROMB, V12, P295, DOI 10.5551/jat.12.295
NR 307
TC 76
Z9 76
U1 0
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2021
VL 13
IS 2
AR 630
DI 10.3390/nu13020630
PG 33
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA QO1UG
UT WOS:000622931300001
PM 33669163
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Matsunaga, T
   Nishikawa, K
   Adachi, T
   Yasuda, K
AF Matsunaga, Tetsuro
   Nishikawa, Kazutaka
   Adachi, Tetsuya
   Yasuda, Koichiro
TI Associations between dietary consumption and sleep quality in young
   Japanese males
SO SLEEP AND BREATHING
LA English
DT Article
DE Sleep quality; Diet; Mental health; Young Japanese males
ID HISTORY QUESTIONNAIRES; DURATION; INSOMNIA; VALIDITY; ADULTS; HEALTH;
   INDEX; FOOD
AB Purpose Poor sleep quality has been reported to be a risk factor for cardiovascular disease, diabetes, and metabolic syndrome, as well as mental disorders including depression and anxiety. However, few studies have investigated the association between sleep quality and diet in young males. We aimed to assess this association, adjusting for psychological factors. Methods In this study, a total of 124 male Japanese students were analyzed. Sleep quality, diet, and psychological symptoms were assessed using self-reported questionnaires, including the Pittsburgh Sleep Quality Index (PSQI), brief-type self-administered diet history questionnaire (BDHQ), 12-item General Health Questionnaire (GHQ12), and State-Trait Anxiety Inventory (STAI) A-Trait scale. Results Among participants, 40% exhibited a PSQI total score >= 6, indicating poor sleep quality. Poor sleep quality was associated with poor mental health status and higher levels of anxiety. After adjusting for covariates including these psychological factors, poor sleep quality was significantly associated with low intakes of fat, beta-carotene, retinol, alpha-tocopherol, vitamin K, vitamin B-1, daidzein, genistein, and iron. Poor sleep quality was also associated with low intake of pulses, fat and oil, as well as high intakes of sugar-sweetened beverages. Conclusions Our findings demonstrated that sleep quality among young Japanese males was associated with specific dietary features, independently of psychological status, which may help to elucidate the mechanisms underlying the link between sleep and sleep-related diseases.
C1 [Matsunaga, Tetsuro] Mukogawa Womens Univ, Sch Human Environm Sci, Dept Food Sci & Nutr, 6-46 Ikebiraki Cho, Nishinomiya, Hyogo 6638558, Japan.
   [Matsunaga, Tetsuro; Nishikawa, Kazutaka] Naruto Univ Educ, Fac Hlth & Living Sci Educ, Naruto 7728502, Japan.
   [Adachi, Tetsuya] SenriKinran Univ, Fac Human Life Sci, Dept Food & Nutr, Osaka 5650873, Japan.
   [Yasuda, Koichiro] Saiseikai Noe Hosp, Osaka 5360001, Japan.
C3 Mukogawa Women's University; Naruto University of Education
RP Matsunaga, T (corresponding author), Mukogawa Womens Univ, Sch Human Environm Sci, Dept Food Sci & Nutr, 6-46 Ikebiraki Cho, Nishinomiya, Hyogo 6638558, Japan.; Matsunaga, T (corresponding author), Naruto Univ Educ, Fac Hlth & Living Sci Educ, Naruto 7728502, Japan.
EM tmatsunaga-dm@umin.ac.jp
FU JSPS KAKENHI [JP15K01684]
FX This work was supported by JSPS KAKENHI Grant Number JP15K01684.
CR Buysse D J, 1989, Psychiatry Res, V28, P193
   Cheng FW, 2016, AM J CLIN NUTR, V104, P462, DOI 10.3945/ajcn.116.131060
   Dashti HS, 2015, AM J CLIN NUTR, V101, P135, DOI 10.3945/ajcn.114.095026
   Del Brutto OH, 2016, SLEEP MED, V17, P126, DOI 10.1016/j.sleep.2015.09.021
   Doi Y, 2000, PSYCHIAT RES, V97, P165, DOI 10.1016/S0165-1781(00)00232-8
   Felt BT, 2006, BEHAV BRAIN RES, V171, P261, DOI 10.1016/j.bbr.2006.04.001
   Goldberg DP, 1997, PSYCHOL MED, V27, P191, DOI 10.1017/S0033291796004242
   Hachul H, 2011, MENOPAUSE, V18, P178, DOI 10.1097/gme.0b013e3181ecf9b9
   Hansen AL, 2014, J CLIN SLEEP MED, V10, P567, DOI 10.5664/jcsm.3714
   Katagiri R, 2014, J OCCUP HEALTH, V56, P359, DOI 10.1539/joh.14-0051-OA
   Kobayashi S, 2011, PUBLIC HEALTH NUTR, V14, P1200, DOI 10.1017/S1368980011000504
   Martinez SM, 2017, SLEEP, V40, DOI 10.1093/sleep/zsw057
   Mezick EJ, 2011, SLEEP MED REV, V15, P51, DOI 10.1016/j.smrv.2010.03.001
   Ministry of Health Labour and Welfare, 2014, DIET REF INT JAP
   Murat S, 2015, AFR HEALTH SCI, V15, P621, DOI 10.4314/ahs.v15i2.40
   Ogilvie RP, 2018, PUBLIC HEALTH NUTR, V21, P689, DOI 10.1017/S1368980017003536
   Patrick RP, 2015, FASEB J, V29, P2207, DOI 10.1096/fj.14-268342
   Peuhkuri K, 2012, NUTR RES, V32, P309, DOI 10.1016/j.nutres.2012.03.009
   Sei H, 2008, J MED INVESTIG, V55, P1, DOI 10.2152/jmi.55.1
   Shiraishi M, 2017, J EPIDEMIOL, V27, P172, DOI 10.1016/j.je.2016.05.005
   Spaeth AM, 2013, SLEEP, V36, P981, DOI 10.5665/sleep.2792
   Spielberger G.D., 1970, The State-Trait Anxiety Inventory
   St-Onge MP, 2014, INT J OBESITY, V38, P411, DOI 10.1038/ijo.2013.114
   St-Onge MP, 2016, ADV NUTR, V7, P938, DOI 10.3945/an.116.012336
   Steiger A, 2011, MOL CELL ENDOCRINOL, V340, P88, DOI 10.1016/j.mce.2011.02.013
   Trivedi MS, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0181978
   Weiss A, 2010, SLEEP, V33, P1201, DOI 10.1093/sleep/33.9.1201
   Zadeh SS, 2011, NUTR RES PRACT, V5, P230, DOI 10.4162/nrp.2011.5.3.230
NR 28
TC 5
Z9 5
U1 2
U2 8
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1520-9512
EI 1522-1709
J9 SLEEP BREATH
JI Sleep Breath.
PD MAR
PY 2021
VL 25
IS 1
BP 199
EP 206
DI 10.1007/s11325-020-02077-2
EA MAY 2020
PG 8
WC Clinical Neurology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Respiratory System
GA RB4PM
UT WOS:000531119800001
PM 32385731
DA 2025-06-11
ER

PT J
AU Ledesma, M
   Hurtado-Roca, Y
   Leon, M
   Giraldo, P
   Pocovi, M
   Civeira, F
   Guallar, E
   Ordovas, JM
   Casasnovas, JA
   Laclaustra, M
AF Ledesma, Marta
   Hurtado-Roca, Yamilee
   Leon, Montserrat
   Giraldo, Pilar
   Pocovi, Miguel
   Civeira, Fernando
   Guallar, Eliseo
   Maria Ordovas, Jose
   Antonio Casasnovas, Jose
   Laclaustra, Martin
TI Association of Ferritin Elevation and Metabolic Syndrome in Males.
   Results from the Aragon Workers' Health Study (AWHS)
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID CARDIOVASCULAR RISK-FACTORS; INSULIN-RESISTANCE SYNDROME; KOREAN
   NATIONAL-HEALTH; C-REACTIVE PROTEIN; SERUM FERRITIN; GENERAL-POPULATION;
   OXIDATIVE STRESS; IRON STORES; MEN; INFLAMMATION
AB Context: Ferritin concentration is associated with metabolic syndrome, but the possibility of a nonlinear association has never been explored.
   Objective: This study aimed to examine the relationship between serum ferritin levels and the metabolic syndrome in Spanish adult males.
   Design: This was a cross-sectional analysis of baseline data from the Aragon Workers' Health Study.
   Setting: Healthy workers from a factory were studied during their annual checkup.
   Participants: Spanish male adults (n = 3386) between the ages of 19 and 65 years participated. We excluded participants with ferritin > 500 mu g/L, ferritin < 12 mu g/L, or C-reactive protein > 10 mg/L.
   Main Outcome Measure: Metabolic syndrome was defined according to the 2009 consensus definition from the Joint Interim Statement of several international societies.
   Results: Metabolic syndrome prevalence was 27.1%. We found a positive association between elevated iron stores, measured as serum ferritin concentration, and metabolic syndrome and its criteria. Participants within the highest serum ferritin quintile had a higher risk than those in the lowest quintile for central obesity (odds ratio [OR], 1.88; 95% confidence interval [CI], 1.46-2.42), hypertriglyceridemia (OR, 2.15; 95% CI, 1.69-2.74), and metabolic syndrome (OR, 1.92; 95% CI, 1.48-2.49). The association was nonlinear and occurred at serum ferritin concentrations > 100 mu g/L (similar to 33th percentile). Ferritin was also associated with insulin resistance, measured by homeostatic model assessment-insulin resistance (HOMA-IR) (P trend < .001).
   Conclusions: Our findings suggest that serum ferritin is significantly associated with metabolic syndrome and its criteria (especially central obesity and hypertriglyceridemia), suggesting that ferritin could be an early marker of metabolic damage in the development of metabolic syndrome.
C1 [Ledesma, Marta; Leon, Montserrat; Giraldo, Pilar; Pocovi, Miguel; Civeira, Fernando; Antonio Casasnovas, Jose] Inst Aragones Ciencias Salud, Zaragoza 50009, Spain.
   [Hurtado-Roca, Yamilee; Maria Ordovas, Jose; Laclaustra, Martin] Spanish Natl Ctr Cardiovasc Res, Dept Epidemiogy Atherothrombosis & Imaging, Madrid 28029, Spain.
   [Giraldo, Pilar] CIBERER, Zaragoza 50009, Spain.
   [Guallar, Eliseo] Johns Hopkins Bloomberg Sch Publ Hlth, Welch Ctr Prevent Epidemiol & Clin Res, Dept Epidemiol, Baltimore, MD 21205 USA.
   [Guallar, Eliseo] Johns Hopkins Bloomberg Sch Publ Hlth, Welch Ctr Prevent Epidemiol & Clin Res, Dept Med, Baltimore, MD 21205 USA.
   [Laclaustra, Martin] Univ Autonoma Madrid, Sch Med, Dept Prevent Med & Publ Hlth, Madrid 28029, Spain.
   [Laclaustra, Martin] St Louis Univ, Dept Epidemiol, St Louis, MO 63104 USA.
C3 Centro Nacional de Investigaciones Cardiovasculares (CNIC); CIBER -
   Centro de Investigacion Biomedica en Red; CIBERER; Johns Hopkins
   University; Johns Hopkins Bloomberg School of Public Health; Johns
   Hopkins University; Johns Hopkins Bloomberg School of Public Health;
   Autonomous University of Madrid; Saint Louis University
RP Ledesma, M (corresponding author), Ctr Nacl Invest Cardiovasc, Dept Epidemiogy Atherothrombosis & Imaging, C Melchor Fernandez Almagro 3, Madrid 28029, Spain.
EM mlaclaustra@cnic.es
RI Martínez, J./K-8709-2014; Casasnovas, Jose Antonio/F-4038-2010;
   Laclaustra, Martin/C-6709-2015
OI Casasnovas, Jose Antonio/0000-0002-9887-2629; Laclaustra,
   Martin/0000-0003-3963-0846; HURTADO-ROCA, YAMILEE/0000-0003-1993-6223
FU Instituto Aragones de Ciencias de la Salud (I+CS); Spanish National
   Center for Cardiovascular Research (Centro Nacional de Investigaciones
   Cardiovasculares); Instituto de Salud Carlos III [FIS CP08/00112,
   PI10/00021, PI14/00009]; Peruvian government [088-FINCyT-BDE-2014]; FIS
   [PI12/01703, PI12/01434]
FX The Aragon Workers' Health Study is funded by Instituto Aragones de
   Ciencias de la Salud (I+CS) and the Spanish National Center for
   Cardiovascular Research (Centro Nacional de Investigaciones
   Cardiovasculares). M.La. was supported in part by Grants FIS CP08/00112,
   PI10/00021, and PI14/00009 from the Instituto de Salud Carlos III.
   Y.H.-R. was supported by Scholarship NO. 088-FINCyT-BDE-2014 from the
   Peruvian government. M.P. was supported by FIS PI12/01703. M.Leo. was
   supported by FIS PI12/01434.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Bozzini C, 2005, DIABETES CARE, V28, P2061, DOI 10.2337/diacare.28.8.2061
   Casanova-Esteban P, 2011, METABOLISM, V60, P830, DOI 10.1016/j.metabol.2010.07.035
   Casasnovas JA, 2012, BMC CARDIOVASC DISOR, V12, DOI 10.1186/1471-2261-12-45
   COOK JD, 1974, AM J CLIN NUTR, V27, P681, DOI 10.1093/ajcn/27.7.681
   Cooksey RC, 2004, ENDOCRINOLOGY, V145, P5305, DOI 10.1210/en.2004-0392
   Crownover BK, 2013, AM FAM PHYSICIAN, V87, P183
   DAVIS RJ, 1986, J BIOL CHEM, V261, P8708
   Fernández-Real JM, 2002, DIABETES, V51, P1000, DOI 10.2337/diabetes.51.4.1000
   Gabrielsen JS, 2012, J CLIN INVEST, V122, P3529, DOI 10.1172/JCI44421
   Gillum RF, 2001, INT J OBESITY, V25, P639, DOI 10.1038/sj.ijo.0801561
   González AS, 2006, EUR J CLIN NUTR, V60, P802, DOI 10.1038/sj.ejcn.1602384
   Halle M, 1997, ATHEROSCLEROSIS, V128, P235, DOI 10.1016/S0021-9150(96)05994-1
   Jehn M, 2004, DIABETES CARE, V27, P2422, DOI 10.2337/diacare.27.10.2422
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kim CH, 2011, METABOLISM, V60, P414, DOI 10.1016/j.metabol.2010.03.007
   Lee BK, 2011, METABOLISM, V60, P1416, DOI 10.1016/j.metabol.2011.02.008
   LEE KS, 1995, J CLIN INVEST, V96, P2461, DOI 10.1172/JCI118304
   Moreno-Navarrete JM, 2014, DIABETES CARE, V37, P1092, DOI 10.2337/dc13-1602
   Mateo-Gallego R, 2010, METABOLISM, V59, P154, DOI 10.1016/j.metabol.2009.06.021
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McClain DA, 2006, DIABETOLOGIA, V49, P1661, DOI 10.1007/s00125-006-0200-0
   Ordovas JM, 2008, KIDNEY INT, V74, pS10, DOI 10.1038/ki.2008.517
   Park SK, 2012, DIABETES CARE, V35, P2521, DOI 10.2337/dc12-0543
   Parola M, 2011, ANTIOXID REDOX SIGN, V15, P461, DOI 10.1089/ars.2010.3848
   Piperno A, 2002, J HYPERTENS, V20, P1513, DOI 10.1097/00004872-200208000-00013
   Rajpathak SN, 2009, BBA-GEN SUBJECTS, V1790, P671, DOI 10.1016/j.bbagen.2008.04.005
   Tamakoshi K, 2003, INT J OBESITY, V27, P443, DOI 10.1038/sj.ijo.0802260
   Tuomainen TP, 1997, DIABETES CARE, V20, P426, DOI 10.2337/diacare.20.3.426
   Vagu C, 2013, HEPAT MON, V13, DOI 10.5812/hepatmon.13136
   Vari IS, 2007, DIABETES CARE, V30, P1795, DOI 10.2337/dc06-2312
   Wessling-Resnick M, 2010, ANNU REV NUTR, V30, P105, DOI 10.1146/annurev.nutr.012809.104804
   Williams MJA, 2002, ATHEROSCLEROSIS, V165, P179, DOI 10.1016/S0021-9150(02)00233-2
   Wood MJ, 2012, HEPATOLOGY, V56, P904, DOI 10.1002/hep.25720
   Wrede CE, 2006, EUR J ENDOCRINOL, V154, P333, DOI 10.1530/eje.1.02083
   Wu JP, 2014, ARCH MED RES, V45, P251, DOI 10.1016/j.arcmed.2014.03.004
   Yoo KD, 2012, CLIN ENDOCRINOL, V77, P233, DOI 10.1111/j.1365-2265.2011.04248.x
NR 37
TC 17
Z9 18
U1 0
U2 5
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD MAY
PY 2015
VL 100
IS 5
BP 2081
EP 2089
DI 10.1210/jc.2014-4409
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CM4QG
UT WOS:000357669000065
PM 25695891
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Kar, N
   Barreto, S
AF Kar, Nilamadhab
   Barreto, Socorro
TI Influence of Lifestyle Factors on Metabolic Syndrome in Psychiatric
   Patients Attending a Community Mental Health Setting: A Cross-sectional
   Study
SO INDIAN JOURNAL OF PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Cardiovascular diseases; diet; exercise; mental disorder; metabolic
   syndrome; quality of life
ID QUALITY-OF-LIFE; SCHIZOPHRENIA-PATIENTS; PREVALENCE; PEOPLE; RISK;
   ANTIPSYCHOTICS; ILLNESS; DEFINITION; DISORDERS; PREDICTORS
AB Background: Metabolic syndrome (MetS) is a concern in psychiatric patients. We aimed to study the influence of the modifiable lifestyle factors on MetS in adult psychiatric patients along with associated clinical factors and quality of life.Methods: Factors such as diet (Healthy Eating Index), exercise, substance use, cardiovascular risk (QRISK), illness severity (Clinical Global Impression), medications, adverse events (Systematic Monitoring of Adverse Events Related to Treatments), and quality of life (Recovering Quality of Life Scale) were assessed along with clinical components for MetS in 323 psychiatric patients receiving routine care and monitoring in a Community Mental Health Team.Results: MetS was present in 50.5% (95% CI: 45.0-55.9). It was significantly associated with higher age, duration of mental illness, body mass index (BMI), QTc, QRISK, and antipsychotic drugs. In logistic regression, age, QTc, QRISK, and BMI remained significantly linked to MetS. Patients with or without MetS were comparable in their lifestyle factors such as diet, exercise, and substance use, along with the family history of metabolic disorders, age at onset of mental illness, duration of antipsychotic medication, side effects, psychiatric diagnoses, and quality of life. However, many patients with or without MetS had poorer diet and physical inactivity, indicating scope for interventions.Conclusions: Around half of the psychiatric patients had MetS, and modifiable lifestyle factors did not differentiate individuals with or without MetS. The need for further research on the prevention and management of MetS in psychiatric patients is highlighted.
C1 [Kar, Nilamadhab] Univ Wolverhampton, Wolverhampton, England.
   [Kar, Nilamadhab; Barreto, Socorro] Black Country Healthcare NHS Fdn Trust, Dept Psychiat, Wolverhampton, England.
   [Kar, Nilamadhab] Black Country Healthcare NHS Fdn Trust, Low Hill, Wolverhampton WV10 9TH, England.
C3 University of Wolverhampton
RP Kar, N (corresponding author), Black Country Healthcare NHS Fdn Trust, Low Hill, Wolverhampton WV10 9TH, England.
EM n.kar@nhs.net
RI ; Kar, Nilamadhab/F-9921-2013
OI Barreto, Socorro/0000-0001-8903-5186; Kar,
   Nilamadhab/0000-0002-8801-9245
FU Research and Innovation Department of the Black Country Healthcare NHS
   Foundation Trust; Institute of Insight, United Kingdom
FX We thank Debbie Lester, Jenny Horne, Dr Faiz Masood, Dr Mahum Kiani, Dr
   Amy Boswell, Dr Helen Wheeldon, Dr Zaib Nisa, Dr Jasmin Mahil, Dr Tulika
   Prasad, Dr Sayyid Ahmed, Dr Sadia Zahid, Dr Susmit Roy, Dr Shreyan Kar,
   Dr Faiz Masood, Dr Thanuja Vidyaratne, Dr Amina Rashid, Dr Brajaballav
   Kar, Dr Nitish Mathur, Alison Grant, Andrew Chapani, Jo Whitehouse, Gaye
   Johnson, for support related to data collection and data quality
   management. We are also thankful to Research and Innovation Department
   of the Black Country Healthcare NHS Foundation Trust and The Institute
   of Insight, United Kingdom.
CR Adjoian Tamar K, 2016, Prev Med Rep, V3, P127, DOI 10.1016/j.pmedr.2016.01.001
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Alzahrani A, 2022, EGYPT J NEUROL PSYCH, V58, DOI 10.1186/s41983-021-00444-8
   Antoniou CK, 2017, EUR CARDIOL REV, V12, P112, DOI 10.15420/ecr.2017:16:1
   Bahall M, 2020, HEALTH QUAL LIFE OUT, V18, DOI 10.1186/s12955-020-01433-w
   Bai YM, 2016, BMC PSYCHIATRY, V16, DOI 10.1186/s12888-016-1143-8
   Banks E, 2019, BMC MED, V17, DOI 10.1186/s12916-019-1351-4
   Barnes TRE, 2007, SCHIZOPHRENIA BULL, V33, P1397, DOI 10.1093/schbul/sbm038
   Bennett ME, 2015, J DUAL DIAGN, V11, P161, DOI 10.1080/15504263.2015.1104481
   BNF, 2022, British national formulary (BNF)
   Bressington D, 2016, BMC PSYCHIATRY, V16, DOI 10.1186/s12888-016-1121-1
   Carli M, 2021, PHARMACEUTICALS-BASE, V14, DOI 10.3390/ph14030238
   Chadda RK, 2013, J PHARMACOL PHARMACO, V4, P176, DOI 10.4103/0976-500X.114596
   Cooper SJ, 2016, J PSYCHOPHARMACOL, V30, P717, DOI 10.1177/0269881116645254
   Correll CU, 2007, SCHIZOPHR RES, V89, P91, DOI 10.1016/j.schres.2006.08.017
   Correll CU, 2022, WORLD PSYCHIATRY, V21, P248, DOI 10.1002/wps.20994
   Correll CU, 2015, WORLD PSYCHIATRY, V14, P119, DOI 10.1002/wps.20204
   Cyrus S.H., 2014, Advances in Psychiatric Treatment, V20, P101, DOI 10.1192/apt.bp.113.011619
   Darcin AE, 2015, SCHIZOPHR RES, V166, P201, DOI 10.1016/j.schres.2015.05.004
   Das D, 2017, INDIAN J PSYCHIAT, V59, P228, DOI 10.4103/psychiatry.IndianJPsychiatry_64_16
   De Hert M, 2009, WORLD PSYCHIATRY, V8, P15
   Djärv T, 2012, BMJ OPEN, V2, DOI 10.1136/bmjopen-2012-001554
   Firth J, 2016, PSYCHOL MED, V46, P2869, DOI 10.1017/S0033291716001732
   Gilbody S, 2019, LANCET PSYCHIAT, V6, P379, DOI 10.1016/S2215-0366(19)30047-1
   Gouveia ÉR, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18031303
   Grover Sandeep, 2012, Indian J Psychol Med, V34, P110, DOI 10.4103/0253-7176.101767
   Guy W., 2022, ECDEU ASSESSMENT MAN
   Hackshaw A, 2018, BMJ-BRIT MED J, V360, DOI [10.1136/bmj.j5855, 10.1136/bmj.k1611]
   Haddad PM, 2014, THER ADV PSYCHOPHARM, V4, P15, DOI 10.1177/2045125313510195
   Heart UK, WHAT IS MET SYNDR
   Hippisley-Cox J, 2017, BMJ-BRIT MED J, V357, DOI 10.1136/bmj.j2099
   Hjorthoj C, 2017, LANCET PSYCHIAT, V4, P295, DOI 10.1016/S2215-0366(17)30078-0
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Jaberi N, 2020, CASP J INTERN MED, V11, P310, DOI 10.22088/cjim.11.3.310
   Kahl KG, 2013, EUR ARCH PSY CLIN N, V263, P205, DOI 10.1007/s00406-012-0339-2
   Kar N, 2016, CLIN PSYCHOPHARM NEU, V14, P323, DOI 10.9758/cpn.2016.14.4.323
   Keetharuth AD, 2018, BRIT J PSYCHIAT, V212, P42, DOI 10.1192/bjp.2017.10
   Khosravi M, 2020, ANN GEN PSYCHIATR, V19, DOI 10.1186/s12991-020-00314-2
   Kwak Y, 2021, IRAN J PUBLIC HEALTH, V50, P1352, DOI 10.18502/ijph.v50i7.6624
   Launders N, 2022, PLOS MED, V19, DOI 10.1371/journal.pmed.1003976
   Lee JS, 2017, PSYCHIAT INVEST, V14, P44, DOI 10.4306/pi.2017.14.1.44
   Lieberman Joseph A 3rd, 2004, Prim Care Companion J Clin Psychiatry, V6, P8
   Lind L, 2019, METAB SYNDR RELAT D, V17, P505, DOI 10.1089/met.2019.0070
   Mazereel V, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.573479
   McEvoy JP, 2005, SCHIZOPHR RES, V80, P19, DOI 10.1016/j.schres.2005.07.014
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Newcomer JW, 2007, AM J MANAG CARE, V13, pS170
   Newcomer JW, 2006, CAN J PSYCHIAT, V51, P480, DOI 10.1177/070674370605100803
   NHS, 2022, nhs.uk
   NHS, 2023, NHSUK
   NICE, 2014, 1 RECOMMENDATIONS PS
   NICE, 2021, PSYCHOSIS SCHIZOPHRE
   Noubiap JJ, 2022, DIABETES RES CLIN PR, V188, DOI 10.1016/j.diabres.2022.109924
   Pearsall R, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/1471-244X-14-117
   Pillinger T, 2020, LANCET PSYCHIAT, V7, P64, DOI 10.1016/S2215-0366(19)30416-X
   QRISK3, About us
   Riordan HJ, 2011, AM HEALTH DRUG BENEF, V4, P292
   Rivas-Vazquez R A., 2011, Prim Care Companion CNS Disorders, V13
   Rosenbaum S, 2014, J CLIN PSYCHIAT, V75, P964, DOI 10.4088/JCP.13r08765
   Saloojee S, 2018, EARLY INTERV PSYCHIA, V12, P1137, DOI 10.1111/eip.12428
   Schmitt A, 2020, EUR ARCH PSY CLIN N, V270, P499, DOI 10.1007/s00406-020-01156-5
   Schuch FB, 2021, TRENDS PSYCHIATR PSY, V43, P177
   Scuteri A, 2015, EUR J PREV CARDIOL, V22, P486, DOI 10.1177/2047487314525529
   Singh VK, 2023, INDIAN J PSYCHOL MED, V45, P352, DOI 10.1177/02537176231155039
   Singh VK, 2018, SCHIZOPHR RES, V202, P17, DOI 10.1016/j.schres.2018.06.066
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Srisurapanont M, 2007, BMC PSYCHIATRY, V7, DOI 10.1186/1471-244X-7-14
   Teshome T, 2020, DIABETES METAB SYNDR, V13, P569, DOI 10.2147/DMSO.S235379
   Vancampfort D, 2020, J INTELL DISABIL RES, V64, P804, DOI 10.1111/jir.12772
   Vancampfort D, 2016, ALCOHOL ALCOHOLISM, V51, P515, DOI 10.1093/alcalc/agw040
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   WHO, 2004, LANCET, V363, P902, DOI 10.1016/S0140-6736(03)15268-3
   Younis A, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-016-0466-6
   Zhong YH, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-81653-2
NR 75
TC 0
Z9 0
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0253-7176
EI 0975-1564
J9 INDIAN J PSYCHOL MED
JI Indian J. Psychol. Med.
PD JUL
PY 2024
VL 46
IS 4
BP 313
EP 322
DI 10.1177/02537176231219770
EA JAN 2024
PG 10
WC Psychiatry; Psychology
WE Emerging Sources Citation Index (ESCI)
SC Psychiatry; Psychology
GA ZH3C0
UT WOS:001153549800001
PM 39056040
OA gold
DA 2025-06-11
ER

PT S
AU Straub, RH
AF Straub, Rainer H.
BE Cutolo, M
   Straub, RH
   Masi, AT
   Bijlsma, JWJ
TI Systemic disease sequelae in chronic inflammatory diseases and chronic
   psychological stress: comparison and pathophysiological model
SO STEROIDS IN NEUROENDOCRINE IMMUNOLOGY AND THERAPY OF RHEUMATIC DISEASES
   II
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 5th International Conference on the Neuroendocrine Immune Basis of the
   Rheumatic Diseases (NEIRD)
CY OCT 01-03, 2013
CL Genoa, ITALY
DE chronic inflammatory disease; rheumatoid arthritis; psychological
   stress; systemic disease sequelae
ID BODY-MASS INDEX; EARLY RHEUMATOID-ARTHRITIS; PITUITARY-ADRENAL AXIS;
   TUMOR-NECROSIS-FACTOR; SYMPATHETIC-NERVE FIBERS;
   GLUCOCORTICOID-RECEPTOR; ENERGY-EXPENDITURE; IN-VITRO; ADRENOCORTICAL
   AXIS; PSYCHOSOCIAL STRESS
AB In chronic inflammatory diseases (CIDs), the neuroendocrine-immune crosstalk is important to allocate energy-rich substrates to the activated immune system. Since the immune system can request energy-rich substrates independent of the rest of the body, I refer to it as the "selfish immune system," an expression that was taken from the theory of the "selfish brain," giving the brain a similar position. In CIDs, the theory predicts the appearance of long-term disease sequelae, such as metabolic syndrome. Since long-standing energy requirements of the immune system determine disease sequelae, the question arose as to whether chronic psychological stress due to chronic activation of the brain causes similar sequelae. Indeed, there are many similarities; however, there are also differences. A major difference is the behavior of body weight (constant in CIDs versus loss or gain in stress). To explain this discrepancy, a new pathophysiological theory is presented that places inflammation and stress axes in the middle.
C1 Univ Hosp Regensburg, Dept Internal Med 1, Lab Expt Rheumatol & Neuroendocrine Immunol, D-93053 Regensburg, Germany.
C3 University of Regensburg
RP Straub, RH (corresponding author), Univ Hosp Regensburg, Dept Internal Med 1, Lab Expt Rheumatol & Neuroendocrine Immunol, BIOPARK 1,Josef Engert Str 9, D-93053 Regensburg, Germany.
EM rainer.straub@ukr.de
OI Straub, Rainer H/0000-0003-1165-4555
CR Block JP, 2009, AM J EPIDEMIOL, V170, P181, DOI 10.1093/aje/kwp104
   Bornstein SR, 2008, TRENDS ENDOCRIN MET, V19, P175, DOI 10.1016/j.tem.2008.01.009
   BOYLE PJ, 1994, J CLIN INVEST, V93, P529, DOI 10.1172/JCI117003
   Brunner EJ, 2007, AM J EPIDEMIOL, V165, P828, DOI 10.1093/aje/kwk058
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Dallman MF, 2010, TRENDS ENDOCRIN MET, V21, P159, DOI 10.1016/j.tem.2009.10.004
   DAUNCEY MJ, 1981, BRIT J NUTR, V45, P257, DOI 10.1079/BJN19810102
   de Vries A, 2007, J CLIN INVEST, V117, P1058, DOI 10.1172/JCI30982
   DIBATTISTA JA, 1991, J RHEUMATOL, V18, P102
   DONG Y, 1989, J BIOL CHEM, V264, P13679
   Edwards C, 2012, J CLIN ENDOCR METAB, V97, P1443, DOI 10.1210/jc.2011-2879
   Ehrhart-Bornstein M, 1998, ENDOCR REV, V19, P101, DOI 10.1210/er.19.2.101
   Eickelberg O, 1999, J BIOL CHEM, V274, P1005, DOI 10.1074/jbc.274.2.1005
   Escalante A, 2005, ARCH INTERN MED, V165, P1624, DOI 10.1001/archinte.165.14.1624
   Feske S, 2007, NAT REV IMMUNOL, V7, P690, DOI 10.1038/nri2152
   FONG YM, 1990, J CLIN INVEST, V85, P1896, DOI 10.1172/JCI114651
   FOX PT, 1988, SCIENCE, V241, P462, DOI 10.1126/science.3260686
   FRASER G, 1989, J APPL PHYSIOL, V66, P830, DOI 10.1152/jappl.1989.66.2.830
   GISSLINGER H, 1993, NEUROENDOCRINOLOGY, V57, P489, DOI 10.1159/000126396
   Gold PW, 2002, MOL PSYCHIATR, V7, P254, DOI 10.1038/sj.mp.4001032
   Gouin JP, 2008, NEUROIMMUNOMODULAT, V15, P251, DOI 10.1159/000156468
   GRUOL DJ, 1986, J BIOL CHEM, V261, P4909
   Hamer M, 2012, J CLIN ENDOCR METAB, V97, pE29, DOI 10.1210/jc.2011-2132
   Härle P, 2006, ANN RHEUM DIS, V65, P51, DOI 10.1136/ard.2005.038059
   Hitze Britta, 2010, Front Neuroenergetics, V2, P7, DOI 10.3389/fnene.2010.00007
   Jastreboff AM, 2013, DIABETES CARE, V36, P394, DOI 10.2337/dc12-1112
   Jessop DS, 2005, RHEUMATOLOGY, V44, P1097, DOI 10.1093/rheumatology/keh644
   Kaufmann J, 2003, J RHEUMATOL, V30, P2350
   Kiecolt-Glaser JK, 2003, P NATL ACAD SCI USA, V100, P9090, DOI 10.1073/pnas.1531903100
   KIRSCHBAUM C, 1993, NEUROPSYCHOBIOLOGY, V28, P76, DOI 10.1159/000119004
   Korkeila M., 1998, J OBES RELAT METAB D, V22, P949
   Korn SH, 1998, BIOCHEM PHARMACOL, V56, P1561, DOI 10.1016/S0006-2952(98)00179-8
   Lamers F, 2013, MOL PSYCHIATR, V18, P692, DOI 10.1038/mp.2012.144
   Lutgendorf SK, 1999, J GERONTOL A-BIOL, V54, pM434, DOI 10.1093/gerona/54.9.M434
   MASTORAKOS G, 1993, J CLIN ENDOCR METAB, V77, P1690, DOI 10.1210/jc.77.6.1690
   Miller LE, 2000, FASEB J, V14, P2097, DOI 10.1096/fj.99-1082com
   NAKADA MT, 1987, MOL PHARMACOL, V31, P377
   Nakata Akinori, 2012, Methods Mol Biol, V934, P39, DOI 10.1007/978-1-62703-071-7_3
   O'Connor TG, 2005, BIOL PSYCHIAT, V58, P211, DOI 10.1016/j.biopsych.2005.03.032
   OIKARINEN J, 1984, BIOCHIM BIOPHYS ACTA, V799, P158, DOI 10.1016/0304-4165(84)90290-3
   Painter RC, 2008, BJOG-INT J OBSTET GY, V115, P1243, DOI 10.1111/j.1471-0528.2008.01822.x
   Peters A, 2004, NEUROSCI BIOBEHAV R, V28, P143, DOI 10.1016/j.neubiorev.2004.03.002
   Peters Achim, 2009, Front Neuroenergetics, V1, P2, DOI 10.3389/neuro.14.002.2009
   PHELPS ME, 1981, SCIENCE, V211, P1445, DOI 10.1126/science.6970412
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Räikkönen K, 2010, PSYCHONEUROENDOCRINO, V35, P1587, DOI 10.1016/j.psyneuen.2010.04.010
   Rall LC, 2002, ARTHRITIS RHEUM, V46, P2574, DOI 10.1002/art.10714
   RAVUSSIN E, 1986, J CLIN INVEST, V78, P1568, DOI 10.1172/JCI112749
   ROUBENOFF R, 1994, J CLIN INVEST, V93, P2379, DOI 10.1172/JCI117244
   ROUBENOFF R, 1992, J RHEUMATOL, V19, P1505
   SALDANHA C, 1986, CLIN EXP RHEUMATOL, V4, P365
   SCHAUENSTEIN K, 1987, J IMMUNOL, V139, P1830
   Schmidt P, 2001, MOL ENDOCRINOL, V15, P553, DOI 10.1210/me.15.4.553
   Serlachius A, 2007, PHYSIOL BEHAV, V92, P548, DOI 10.1016/j.physbeh.2007.04.032
   Sjögren E, 2006, BRAIN BEHAV IMMUN, V20, P270, DOI 10.1016/j.bbi.2005.08.001
   SPATHSCHWALBE E, 1994, J CLIN ENDOCR METAB, V79, P1212, DOI 10.1210/jc.79.4.1212
   SPATHSCHWALBE E, 1989, IMMUNOPHARMACOLOGY, V17, P141, DOI 10.1016/0162-3109(89)90042-8
   STERNBERG EM, 1989, P NATL ACAD SCI USA, V86, P4771, DOI 10.1073/pnas.86.12.4771
   Straub R, 2011, CLIN EXP RHEUMAT S68, V29, pS15
   Straub RH, 2010, J INTERN MED, V267, P543, DOI 10.1111/j.1365-2796.2010.02218.x
   Straub RH, 2006, ARTHRITIS RHEUM-US, V54, P2039, DOI 10.1002/art.21946
   Straub RH, 2012, J MOL MED, V90, P523, DOI 10.1007/s00109-012-0861-8
   Straub RH, 2011, ARTHRITIS RHEUM-US, V63, P3234, DOI 10.1002/art.30516
   Straub RH, 2003, FASEB J, V17, P2176, DOI 10.1096/fj.03-0433hyp
   Straub RH, 2002, J NEUROIMMUNOL, V126, P116, DOI 10.1016/S0165-5728(02)00047-4
   Straub RH, 2002, ARTHRITIS RHEUM, V46, P654, DOI 10.1002/art.10177
   Straub RH, 1998, J CLIN ENDOCR METAB, V83, P2012, DOI 10.1210/jc.83.6.2012
   Tsigos C, 1997, NEUROENDOCRINOLOGY, V66, P54, DOI 10.1159/000127219
   van den Bergh BRH, 2008, NEUROPSYCHOPHARMACOL, V33, P536, DOI 10.1038/sj.npp.1301450
   van der Helm-van Mil AHM, 2008, ANN RHEUM DIS, V67, P769, DOI 10.1136/ard.2007.078832
   Welberg LAM, 2001, J NEUROENDOCRINOL, V13, P113, DOI 10.1046/j.1365-2826.2001.00601.x
   Westhoff G, 2007, ARTHRITIS RHEUM-US, V56, P3575, DOI 10.1002/art.23033
   Williams ED, 2013, ANN BEHAV MED, V46, P62, DOI 10.1007/s12160-013-9473-y
   Wyrwoll CS, 2012, NEUROENDOCRINOLOGY, V95, P47, DOI 10.1159/000331345
   Yehuda R, 2005, J CLIN ENDOCR METAB, V90, P4115, DOI 10.1210/jc.2005-0550
NR 75
TC 8
Z9 9
U1 0
U2 15
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2014
VL 1318
BP 7
EP 17
DI 10.1111/nyas.12409
PG 11
WC Endocrinology & Metabolism; Immunology; Rheumatology
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Rheumatology
GA BA7XF
UT WOS:000337847000002
PM 24738934
DA 2025-06-11
ER

PT J
AU Brown, MA
   Gellatley, W
   Hoffman, A
   Dowdell, L
   Camac, A
   Francois, R
   Boston, B
   Zekry, A
AF Brown, Mark A.
   Gellatley, Wendy
   Hoffman, Anna
   Dowdell, Lisa
   Camac, Anne
   Francois, Rachel
   Boston, Belinda
   Zekry, Amany
TI Medical complications of homelessness: a neglected side of men's health
SO INTERNAL MEDICINE JOURNAL
LA English
DT Article
DE homelessness; mental health; addiction; cardiovascular disease;
   hepatitis C
ID PEOPLE; SYDNEY; DISORDERS
AB Background: Homelessness is an increasing societal and health issue associated with high rates of substance abuse and mental health disorders. Homeless people die more often and at a younger age than others. Aim: To identify health needs and improve healthcare for homeless men.
   Methods: A physician-led clinic was established on-site at the Mission Australia Centre in Sydney, incorporating: (i) liver screening, including portable fibroscan testing, and on-site treatment of hepatitis C; (ii) a mental health clinic, staffed by a psychiatrist; and (iii) a nurse-led clinic to follow up medical issues and deliver vaccinations. Patient data were recorded prospectively to determine what medical problems were encountered so as to drive future healthcare planning.
   Results: A total of 257 men was assessed between November 2011 and December 2017. In that time, 561 men resided at the Centre. Of these 257 men who attended the clinic, 61% were <45 years old; 69% were current and 8% former smokers; 62% had a history of chronic alcoholic abuse and 66% other substance abuse; 64% had one or more of depression, anxiety, psychosis or another mental health disorder and 44% had metabolic syndrome features, 38% cardiovascular disease, 29% hepatitis C and 21% a respiratory disorder.
   Conclusion: The main health needs of homeless men fall into the categories of mental health; cardiovascular, respiratory and metabolic disorders and addictions and hepatitis C. Establishing on-site clinics at homeless shelters with expertise to address these issues will likely improve the well-being of these men, reduce hospital admissions and prolong their lives.
C1 [Brown, Mark A.; Hoffman, Anna; Camac, Anne] St George Hosp, Dept Renal Med, Sydney, NSW, Australia.
   [Dowdell, Lisa; Zekry, Amany] St George Hosp, Dept Gastroenterol, Sydney, NSW, Australia.
   [Boston, Belinda] St George Hosp, Dept Infect Control, Sydney, NSW, Australia.
   [Brown, Mark A.; Zekry, Amany] Univ NSW, Sydney, NSW, Australia.
   [Gellatley, Wendy] Optimus Clin Res, Sydney, NSW, Australia.
   [Francois, Rachel] Mission Australia Ctr, Sydney, NSW, Australia.
C3 St George Hospital; St George Hospital; St George Hospital; University
   of New South Wales Sydney; Optimus Clinical Research
RP Brown, MA (corresponding author), St George Hosp, Dept Renal Med, Kogarah, NSW 2217, Australia.
EM mark.brown1@health.nsw.gov.au
RI Richard, François/HJA-3350-2022; zekry, amany/ABC-9995-2020
OI Brown, Mark/0000-0002-4759-9407; ZEKRY, AMANY/0000-0002-5675-1810
CR Babidge NC, 2001, ACTA PSYCHIAT SCAND, V103, P105, DOI 10.1034/j.1600-0447.2001.00192.x
   Chin CN, 2011, AUST HEALTH REV, V35, P52, DOI 10.1071/AH09824
   Degenhardt L, 2017, LANCET GLOB HEALTH, V5, pE1192, DOI 10.1016/S2214-109X(17)30375-3
   Fazel S, 2014, LANCET, V384, P1529, DOI 10.1016/S0140-6736(14)61132-6
   Gozdzik A, 2015, BMC PUBLIC HEALTH, V15, DOI 10.1186/s12889-015-1472-4
   Grams ME, 2018, KIDNEY INT, V93, P1442, DOI 10.1016/j.kint.2018.01.009
   Gulliford M, 2017, LANCET PUBLIC HEALTH, V2, pE532, DOI 10.1016/S2468-2667(17)30218-9
   Hall W, 2017, LANCET PUBLIC HEALTH, V2, pE530, DOI 10.1016/S2468-2667(17)30220-7
   Moore G, 2011, AUST HEALTH REV, V35, P480, DOI 10.1071/AH10967
   Nielssen O, 2017, AUSTRALAS PSYCHIATRY, V25, P270, DOI 10.1177/1039856217695705
   Nielssen OB, 2018, MED J AUSTRALIA, V208, P169, DOI 10.5694/mja17.00858
   Poulos R, 2007, AUST NZ J PUBL HEAL, V31, P247, DOI 10.1111/j.1467-842X.2007.00056.x
   Steen A, 2018, MED J AUSTRALIA, V208, P167, DOI 10.5694/mja17.01197
   Taylor KM, 2008, AUST NZ J PSYCHIAT, V42, P206, DOI 10.1080/00048670701827218
   Teesson M, 2004, AUST NZ J PSYCHIAT, V38, P162, DOI 10.1111/j.1440-1614.2004.01322.x
   Whittaker E, 2015, DRUG ALCOHOL REV, V34, P379, DOI 10.1111/dar.12257
NR 16
TC 13
Z9 16
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1444-0903
EI 1445-5994
J9 INTERN MED J
JI Intern. Med. J.
PD APR
PY 2019
VL 49
IS 4
BP 455
EP 460
DI 10.1111/imj.14139
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA HW1BX
UT WOS:000466418500006
PM 30324639
DA 2025-06-11
ER

PT J
AU Kerkadi, A
   Alkudsi, DS
   Hamad, S
   Alkeldi, HM
   Salih, R
   Agouni, A
AF Kerkadi, Abdelhamid
   Alkudsi, Dana Samir
   Hamad, Sara
   Alkeldi, Hanan Mohamed
   Salih, Reem
   Agouni, Abdelali
TI The Association between Zinc and Copper Circulating Levels and
   Cardiometabolic Risk Factors in Adults: A Study of Qatar Biobank Data
SO NUTRIENTS
LA English
DT Article
DE Qatar Biobank; zinc; copper; Zn; Cu ratio; cardiometabolic risk;
   metabolic syndrome; adults
ID CORONARY-HEART-DISEASE; SERUM ZINC; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; DIABETES-MELLITUS; OXIDATIVE
   STRESS; FASTING GLUCOSE; TRACE-ELEMENTS; FATTY-ACIDS
AB Cardiometabolic risk (CMR) factors increase the likelihood of developing cardiovascular diseases (CVD). In Qatar, 24% of the total deaths are attributed to CVDs. Several nutritional disturbances have been linked to high risk of CVD. Many studies have discussed the effects of zinc (Zn) and copper (Cu) on CMR factors; however, evidence has been controversial. This investigated the association between CMR factors and the status of Zn and Cu, in addition to Zn/Cu ratio. A total of 575 Qatari men and women aged 18 years and older were obtained from Qatar Biobank. Plasma levels of Zn and Cu were determined using inductively coupled plasma mass spectrometry (ICP-MS). Anthropometric data and CMR factors were determined using standard methods. Adjusted associations between trace minerals and CMR were estimated by logistic regression. Partial correlation was performed to test the strength of the associations. Zn was not strongly correlated (p-value > 0.01) or significantly associated with CMR factors and metabolic syndrome (MetS). Cu levels correlated positively with body mass index (BMI) (0.23; p < 0.001), pulse rate (PR) (0.18; p < 0.001), total cholesterol (0.13; p = 0.01), and high-density lipoproteins (HDL) (0.27; p < 0.001); and negatively with diastolic blood pressure (DBP) (-0.13; p = 0.01). High plasma Cu significantly decreased the risk of metabolic syndrome (MetS) (0.121; p < 0.001). Furthermore, Zn/Cu ratio positively correlated with waist circumference (0.13; p = 0.01), systolic blood pressure (0.13; p < 0.01), and DBP (0.14; p < 0.01); and negatively with BMI (-0.19; p < 0.001), PR (-0.17; p < 0.001), and HDL (-0.27; p < 0.001). High Zn/Cu ratio increased the prevalence of low HDL (4.508; p < 0.001) and MetS (5.570; p < 0.01). These findings suggest that high plasma Cu levels are associated with a protective effect on DBP, HDL and MetS and that high plasma Zn/Cu ratio is associated with the risk of having low HDL and MetS.
C1 [Kerkadi, Abdelhamid; Alkudsi, Dana Samir; Hamad, Sara; Alkeldi, Hanan Mohamed; Salih, Reem] Qatar Univ, Dept Human Nutr, Coll Hlth Sci, QU Hlth, POB 2713, Doha, Qatar.
   [Agouni, Abdelali] Qatar Univ, Dept Pharmaceut Sci, Coll Pharm, QU Hlth, POB 2713, Doha, Qatar.
   [Agouni, Abdelali] Qatar Univ, Biomed & Pharmaceut Res Unit BPRU, QU Hlth, POB 2713, Doha, Qatar.
C3 Qatar University; Qatar University; Qatar University
RP Kerkadi, A (corresponding author), Qatar Univ, Dept Human Nutr, Coll Hlth Sci, QU Hlth, POB 2713, Doha, Qatar.
EM abdel.hamid@qu.edu.qa; da1701633@qu.edu.qa; sh1604803@qu.edu.qa;
   ha1608292@qu.edu.qa; rsalih@qu.edu.qa; aagouni@qu.edu.qa
RI kerkadi, Abdelhamid/E-1475-2018; Agouni, Abdelali/AAP-5298-2020
OI kerkadi, abdelhamid/0000-0003-4078-1406; Agouni,
   Abdelali/0000-0002-8363-1582
FU Qatar University Research Support Office [QUST-2-CHS-2020-16]
FX This study was supported by grant QUST-2-CHS-2020-16 from Qatar
   University Research Support Office.
CR Abdelsalam SS, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9070286
   Ahn BI, 2014, BIOL TRACE ELEM RES, V160, P169, DOI 10.1007/s12011-014-0045-1
   Aigner E, 2015, WORLD J HEPATOL, V7, P177, DOI 10.4254/wjh.v7.i2.177
   Akdas S, 2020, BIOL TRACE ELEM RES, V198, P16, DOI 10.1007/s12011-020-02046-6
   Aliabadi H, 2008, MED HYPOTHESES, V70, P1163, DOI 10.1016/j.mehy.2007.09.019
   ALOTHMAN AA, 1993, P SOC EXP BIOL MED, V204, P97, DOI 10.3181/00379727-204-43640
   ALOTHMAN AA, 1992, J NUTR, V122, P1199, DOI 10.1093/jn/122.6.1199
   Bastola MM, 2020, BMC CARDIOVASC DISOR, V20, DOI 10.1186/s12872-020-01355-x
   BIALKOWSKA M, 1987, ANN NUTR METAB, V31, P327, DOI 10.1159/000177287
   Bin Kwon O, 1999, BIOCHEM MOL BIOL INT, V47, P645
   Bonora E, 2000, DIABETES CARE, V23, P57, DOI 10.2337/diacare.23.1.57
   Brandao-Lima PN, 2018, NUTRIENTS, V10, DOI 10.3390/nu10121948
   Burtis C.A., 2012, Tietz Textbook of Clinical Chemistry and Molecular Diagnotics, V5
   Cabral M, 2021, EUR J NUTR, V60, P3267, DOI 10.1007/s00394-021-02494-3
   Carrère P, 2018, WOMEN HEALTH, V58, P145, DOI 10.1080/03630242.2017.1282396
   Chimienti F, 2005, BIOMETALS, V18, P313, DOI 10.1007/s10534-005-3687-9
   Choi SY, 2018, ACTA PHARMACOL SIN, V39, P1120, DOI 10.1038/aps.2018.25
   Cortese-Krott MM, 2014, REDOX BIOL, V2, P945, DOI 10.1016/j.redox.2014.06.011
   D'Agostino RB, 2001, JAMA-J AM MED ASSOC, V286, P180, DOI 10.1001/jama.286.2.180
   Darroudi S, 2019, BIOL TRACE ELEM RES, V190, P38, DOI 10.1007/s12011-018-1518-4
   DIEZ M, 1989, CANCER-AM CANCER SOC, V63, P726, DOI 10.1002/1097-0142(19890215)63:4<726::AID-CNCR2820630421>3.0.CO;2-P
   DiSilvestro RA, 2012, METABOLISM, V61, P1242, DOI 10.1016/j.metabol.2012.02.002
   Fang CC, 2019, J TRACE ELEM MED BIO, V52, P209, DOI 10.1016/j.jtemb.2018.12.017
   Farooq DM, 2020, J FAM COMMUNITY MED, V27, P29, DOI 10.4103/jfcm.JFCM_113_19
   Feige JN, 2006, PROG LIPID RES, V45, P120, DOI 10.1016/j.plipres.2005.12.002
   Filipe P, 2002, EUR J BIOCHEM, V269, P5474, DOI 10.1046/j.1432-1033.2002.03245.x
   Ford ES, 2000, AM J EPIDEMIOL, V151, P1182, DOI 10.1093/oxfordjournals.aje.a010168
   Freitas EPS, 2017, NUTRIENTS, V9, DOI 10.3390/nu9020175
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Fukai T, 2018, AM J PHYSIOL-CELL PH, V315, pC186, DOI 10.1152/ajpcell.00132.2018
   Gomez NN, 2006, BRIT J NUTR, V96, P1038, DOI 10.1017/BJN20061951
   Gomez NN, 2002, LIPIDS, V37, P291, DOI 10.1007/s11745-002-0893-3
   Gonoodi K, 2018, CLIN BIOCHEM, V54, P25, DOI 10.1016/j.clinbiochem.2018.02.006
   Hamasaki H, 2016, FRONT ENDOCRINOL, V7, DOI 10.3389/fendo.2016.00147
   Hara T, 2017, J PHYSIOL SCI, V67, P283, DOI 10.1007/s12576-017-0521-4
   Ho M, 2017, EUR J NUTR, V56, P2407, DOI 10.1007/s00394-016-1280-3
   Klevay LM, 2000, J NUTR, V130, p489S, DOI 10.1093/jn/130.2.489S
   Knez M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010093
   KOK FJ, 1988, AM J EPIDEMIOL, V128, P352, DOI 10.1093/oxfordjournals.aje.a114975
   Leiter LA, 2011, CAN J CARDIOL, V27, DOI 10.1016/j.cjca.2010.12.054
   Leone N, 2006, EPIDEMIOLOGY, V17, P308, DOI 10.1097/01.ede.0000209454.41466.b7
   Little PJ, 2010, NUTRITION, V26, P1050, DOI 10.1016/j.nut.2010.03.007
   Liu Y, 2015, J BIOL CHEM, V290, P18757, DOI 10.1074/jbc.M115.640524
   LOYKE HF, 1991, BIOL TRACE ELEM RES, V29, P45, DOI 10.1007/BF03032673
   Lubos E, 2011, ANTIOXID REDOX SIGN, V15, P1957, DOI 10.1089/ars.2010.3586
   Ma JX, 2020, ENVIRON INT, V140, DOI 10.1016/j.envint.2020.105802
   Maamoun H, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20071658
   Maamoun H, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00070
   Magrì A, 2016, CHEM-EUR J, V22, P13287, DOI 10.1002/chem.201602816
   Malavolta M, 2015, MECH AGEING DEV, V151, P93, DOI 10.1016/j.mad.2015.01.004
   Malavolta M, 2010, BIOGERONTOLOGY, V11, P309, DOI 10.1007/s10522-009-9251-1
   Maritim AC, 2003, J BIOCHEM MOL TOXIC, V17, P24, DOI 10.1002/jbt.10058
   Marjani A., 2015, Asian J. Pharm. Clin. Res, V8, P358
   Maywald M, 2015, J TRACE ELEM MED BIO, V29, P24, DOI 10.1016/j.jtemb.2014.06.003
   Mazdak H, 2010, INT UROL NEPHROL, V42, P89, DOI 10.1007/s11255-009-9583-4
   Medeiros DM, 2017, BIOL TRACE ELEM RES, V176, P10, DOI 10.1007/s12011-016-0807-z
   Mohammadifard N, 2019, CRIT REV FOOD SCI, V59, P1334, DOI 10.1080/10408398.2017.1406332
   Morrell A, 2017, IUBMB LIFE, V69, P263, DOI 10.1002/iub.1613
   Motamed Soudabe, 2013, N Am J Med Sci, V5, P377, DOI 10.4103/1947-2714.114171
   Murakami H, 2012, CHEM PHARM BULL, V60, P1096, DOI 10.1248/cpb.c12-00078
   Myers SA, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0079316
   Navarro-González D, 2016, PREV MED, V86, P99, DOI 10.1016/j.ypmed.2016.01.022
   Nayak SB, 2016, J CLIN DIAGN RES, V10, pIC8, DOI 10.7860/JCDR/2016/18154.7875
   Nishide M, 2008, CHEM PHARM BULL, V56, P1181, DOI 10.1248/cpb.56.1181
   Norouzi S, 2017, J BIOMED SCI, V24, DOI 10.1186/s12929-017-0394-0
   Obirikorang C, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0129494
   Olechnowicz J, 2018, J PHYSIOL SCI, V68, P19, DOI 10.1007/s12576-017-0571-7
   Otto MCCD, 2011, J NUTR, V141, P1508, DOI 10.3945/jn.111.138115
   Özenç S, 2015, INT J DIABETES DEV C, V35, P514, DOI 10.1007/s13410-015-0327-y
   Palaniswamy S, 2019, J TRACE ELEM MED BIO, V51, P12, DOI 10.1016/j.jtemb.2018.09.003
   Parmar J., 2020, INT J CLIN BIOCH RES, V7, P36, DOI [10.18231/j.ijcbr.2020.007, DOI 10.18231/J.IJCBR.2020.007]
   Patel SA, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0174251
   Perez A, 2018, J TRACE ELEM MED BIO, V50, P560, DOI 10.1016/j.jtemb.2018.03.019
   Qu XH, 2020, BIOACT MATER, V5, P410, DOI 10.1016/j.bioactmat.2020.03.006
   Rayman MP, 2018, FREE RADICAL BIO MED, V127, P46, DOI 10.1016/j.freeradbiomed.2018.02.015
   Reunanen A, 1996, EUR J CLIN NUTR, V50, P431
   Saari JT, 2000, CAN J PHYSIOL PHARM, V78, P848, DOI 10.1139/cjpp-78-10-848
   Sales MC, 2018, J TRACE ELEM MED BIO, V50, P615, DOI 10.1016/j.jtemb.2018.04.026
   Salgueiro MJ, 2001, BIOL TRACE ELEM RES, V81, P215, DOI 10.1385/BTER:81:3:215
   SALTMAN P, 1983, ANN INTERN MED, V98, P823, DOI 10.7326/0003-4819-98-5-823
   Samadi A, 2020, CLIN NUTR, V39, P1849, DOI 10.1016/j.clnu.2019.07.026
   Samson SL, 2014, ENDOCRIN METAB CLIN, V43, P1, DOI 10.1016/j.ecl.2013.09.009
   Sánchez-López C, 2016, INORG CHEM, V55, P10727, DOI 10.1021/acs.inorgchem.6b01963
   Seo JA, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0105990
   Shehab A, 2019, EUR HEART J, V40, P3215
   Simental-Mendia Luis E., 2008, Metabolic Syndrome and Related Disorders, V6, P299, DOI 10.1089/met.2008.0034
   Sladek R, 2007, NATURE, V445, P881, DOI 10.1038/nature05616
   Sobczak AIS, 2019, BIOMETALS, V32, P123, DOI 10.1007/s10534-018-00167-z
   Soinio M, 2007, DIABETES CARE, V30, P523, DOI 10.2337/dc06-1682
   Song M, 2013, OBESITY, V21, P1669, DOI 10.1002/oby.20380
   Song XX, 2018, ANN NUTR METAB, V73, P282, DOI 10.1159/000494032
   Stranges S, 2019, DIABETES OBES METAB, V21, P541, DOI 10.1111/dom.13549
   Sun WX, 2018, J TRACE ELEM MED BIO, V46, P117, DOI 10.1016/j.jtemb.2017.12.005
   Tanaka A, 2009, ENDOCR J, V56, P699, DOI 10.1507/endocrj.K09E-051
   Tang XH, 2001, J NUTR, V131, P1414, DOI 10.1093/jn/131.5.1414
   Tuncay E, 2017, DIABETES, V66, P1346, DOI 10.2337/db16-1099
   Unger G, 2014, ENDOCRINOL NUTR, V61, P533, DOI 10.1016/j.endonu.2014.06.009
   Urso E, 2015, J VASC RES, V52, P172, DOI 10.1159/000438485
   VALSALA P, 1987, J BIOSCIENCES, V12, P137, DOI 10.1007/BF02702965
   Viktorínová A, 2009, METABOLISM, V58, P1477, DOI 10.1016/j.metabol.2009.04.035
   Wen WL, 2020, NUTRIENTS, V12, DOI 10.3390/nu12092666
   World Health Organization, NCD DEATHS CAUS SEX
   World Health Organization, CARD DIS CVDS
   Xia SJ, 2016, J IMMUNOL RES, V2016, DOI 10.1155/2016/8426874
   Xu H, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20010128
   Xu YS, 2012, LANGMUIR, V28, P579, DOI 10.1021/la202902a
   Yang HJ, 2019, METALLOMICS, V11, P1363, DOI 10.1039/c9mt00148d
   Yao BD, 2020, BIOL TRACE ELEM RES, V198, P423, DOI 10.1007/s12011-020-02095-x
   Yao J, 2018, BIOL TRACE ELEM RES, V186, P346, DOI 10.1007/s12011-018-1320-3
   Yary T, 2016, J TRACE ELEM MED BIO, V33, P120, DOI 10.1016/j.jtemb.2015.11.001
   Yin JW, 2019, REDOX BIOL, V24, DOI 10.1016/j.redox.2019.101172
   Zaky DSE., 2013, EGYPT J INT MED, V25, P209, DOI [10.4103/1110-7782.124985, DOI 10.4103/1110-7782.124985]
   Zang XD, 2018, ENVIRON SCI POLLUT R, V25, P16951, DOI 10.1007/s11356-018-1816-6
   Zhao YG, 2012, J NUTR BIOCHEM, V23, P1018, DOI 10.1016/j.jnutbio.2011.05.011
   Zohal M, 2019, DIABETES METAB SYND, V13, P1293, DOI 10.1016/j.dsx.2019.01.019
NR 115
TC 13
Z9 13
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2021
VL 13
IS 8
AR 2729
DI 10.3390/nu13082729
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA UH2GR
UT WOS:000689756900001
PM 34444889
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Booth, AO
   Wang, XD
   Turner, AI
   Nowson, CA
   Torres, SJ
AF Booth, Alison O.
   Wang, Xiaodan
   Turner, Anne I.
   Nowson, Caryl A.
   Torres, Susan J.
TI Diet-Induced Weight Loss Has No Effect on Psychological Stress in
   Overweight and Obese Adults: A Meta-Analysis of Randomized Controlled
   Trials
SO NUTRIENTS
LA English
DT Article
DE diet; weight loss; obesity; stress; adults; meta-analysis
ID QUALITY-OF-LIFE; BODY-WEIGHT; METABOLIC SYNDROME; BEHAVIOR; RISK;
   PERFORMANCE; RESPONSES; WORKLOAD; DISEASE; PROFILE
AB The effect of weight loss on psychological stress is unknown. The study aimed to investigate the effect of diet-induced weight loss in overweight and obese adults on psychological measures of stress through a meta-analysis of randomized controlled trials (RCTs). Databases including Medline Complete, Embase and PsycINFO were searched up to February 2018 for diet-induced weight loss RCTs, which included self-reported assessment of psychological stress. The mean difference between the intervention and control group of changes in stress (interventionbaseline) was used. Ten RCTs were included with 615 participants (502 women, age range 20-80 years). Overall, there was no change in stress (mean difference -0.06, 95% CI: -0.17, 0.06, p = 0.33) and no change in the five studies with a significant reduction in weight in the intervention group compared to a control group that lost no weight (mean difference in weight -3.9 Kg, 95% CI: -5.51, -2.29, p < 0.0001; mean difference in stress 0.04, 95% CI: -0.17, 0.25, p = 0.71). For all analyses, there was low heterogeneity. The benefits of weight loss for those who are overweight and obese do not appear to either increase or reduce psychological stress at the end of the weight loss period.
C1 [Booth, Alison O.; Wang, Xiaodan; Turner, Anne I.; Nowson, Caryl A.; Torres, Susan J.] Deakin Univ, Inst Phys Act & Nutr, Sch Exercise & Nutr Sci, Geelong, Vic 3220, Australia.
C3 Deakin University
RP Torres, SJ (corresponding author), Deakin Univ, Inst Phys Act & Nutr, Sch Exercise & Nutr Sci, Geelong, Vic 3220, Australia.
EM alison.booth@deakin.edu.au; swang17@gmail.com;
   anne.turner@deakin.edu.au; caryl.nowson@deakin.edu.au;
   susan.torres@deakin.edu.au
RI Turner, Anne/ACH-8306-2022
OI Turner, Anne/0000-0002-0682-2860; Nowson, Caryl/0000-0001-6586-7965;
   Torres, Susan/0000-0002-2599-1934
CR [Anonymous], COCHRANE HDB SYSTEMA
   [Anonymous], PUBLICATION BIAS MET
   [Anonymous], 2011, GLOB STRAT DIET PHYS
   [Anonymous], 1999, Obesity: preventing and managing the global epidemic. Report of a WHO consultation on obesity
   Baker F, 2002, PSYCHO-ONCOLOGY, V11, P273, DOI 10.1002/pon.564
   Baune B T, 2006, Ann Gen Psychiatry, V5, P6, DOI 10.1186/1744-859X-5-6
   Bergmann N, 2014, ENDOCR CONNECT, V3, pR55, DOI 10.1530/EC-14-0031
   Blaine BE, 2007, J HEALTH PSYCHOL, V12, P66, DOI 10.1177/1359105307071741
   Borenstein M, 2017, RES SYNTH METHODS, V8, P5, DOI 10.1002/jrsm.1230
   Brinkworth GD, 2009, ARCH INTERN MED, V169, P1873, DOI 10.1001/archinternmed.2009.329
   Buffenstein R, 2000, PHYSIOL BEHAV, V68, P439, DOI 10.1016/S0031-9384(99)00222-X
   Carter MJ, 2014, THER RECREAT J, V48, P275
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Degoutte F, 2006, INT J SPORTS MED, V27, P9, DOI 10.1055/s-2005-837505
   Eyres SL, 2014, NUTRITION, V30, P10, DOI 10.1016/j.nut.2013.05.028
   Figueroa-Fankhanel F, 2014, PSYCHIAT CLIN N AM, V37, P455, DOI 10.1016/j.psc.2014.08.001
   Fontaine KR, 1999, QUAL LIFE RES, V8, P275, DOI 10.1023/A:1008835602894
   Glinski J, 2001, OBES SURG, V11, P581, DOI 10.1381/09608920160557057
   Green MW, 2005, PSYCHONEUROENDOCRINO, V30, P908, DOI 10.1016/j.psyneuen.2005.05.005
   Hammen C, 2005, ANNU REV CLIN PSYCHO, V1, P293, DOI 10.1146/annurev.clinpsy.1.102803.143938
   Imayama I, 2011, INT J BEHAV NUTR PHY, V8, DOI 10.1186/1479-5868-8-118
   Kaukua J, 2003, INT J OBESITY, V27, P1072, DOI 10.1038/sj.ijo.0802366
   Krantz DS, 2002, ANNU REV PSYCHOL, V53, P341, DOI 10.1146/annurev.psych.53.100901.135208
   Kruk J, 2004, CANCER DETECT PREV, V28, P399, DOI 10.1016/j.cdp.2004.07.009
   Laederach-Hofmann K, 2002, INT J EAT DISORDER, V32, P58, DOI 10.1002/eat.10063
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Overgaard D, 2004, INT J OBESITY, V28, P1072, DOI 10.1038/sj.ijo.0802720
   Overgaard D, 2004, OCCUP MED-OXFORD, V54, P35, DOI 10.1093/occmed/kqg135
   Pan HJ, 2011, J CHIN MED ASSOC, V74, P169, DOI 10.1016/j.jcma.2011.01.038
   Prehn K, 2017, CEREB CORTEX, V27, P1765, DOI 10.1093/cercor/bhw008
   Rippe JM, 1998, J AM DIET ASSOC, V98, pS9, DOI 10.1016/S0002-8223(98)00704-4
   Rod NH, 2009, J INTERN MED, V266, P467, DOI 10.1111/j.1365-2796.2009.02124.x
   Rosenbaum S, 2015, METABOLISM, V64, P926, DOI [10.1016/j.metabol.2015.04.009, 10.1016/j.metabol.2015.01.016]
   SHACHAM S, 1983, J PERS ASSESS, V47, P305, DOI 10.1207/s15327752jpa4703_14
   Spielberger C. D., 1983, Manual for the State-Trait-Anxiety Inventory: STAI (form Y)
   Spielberger CD., 2014, Stress and anxiety
   Spielberger G.D., 1970, The State-Trait Anxiety Inventory
   Surwit RS, 1997, AM J CLIN NUTR, V65, P908, DOI 10.1093/ajcn/65.4.908
   Swinburn BA, 2011, LANCET, V378, P804, DOI 10.1016/S0140-6736(11)60813-1
   Tomiyama AJ, 2010, PSYCHOSOM MED, V72, P357, DOI 10.1097/PSY.0b013e3181d9523c
   Torres SJ, 2007, NUTRITION, V23, P887, DOI 10.1016/j.nut.2007.08.008
   Wadden TA, 1996, AM J CLIN NUTR, V63, P461, DOI 10.1093/ajcn/63.3.461
   WADDEN TA, 1985, AM J CLIN NUTR, V41, P533, DOI 10.1093/ajcn/41.3.533
   WADDEN TA, 1987, INT J OBESITY, V11, P239
   WATSON D, 1988, J PERS SOC PSYCHOL, V54, P1063, DOI 10.1037/0022-3514.54.6.1063
   WING RR, 1991, DIABETES CARE, V14, P596, DOI 10.2337/diacare.14.7.596
   Wycherley TP, 2014, J DIABETES INVEST, V5, P94, DOI 10.1111/jdi.12120
   Yamauchi K, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-108
NR 48
TC 7
Z9 9
U1 0
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2018
VL 10
IS 5
AR 613
DI 10.3390/nu10050613
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA GJ3LI
UT WOS:000435196000087
PM 29757978
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Cloete, SA
   Daniels, FM
AF Cloete, Shoemeney A.
   Daniels, Felicity M.
TI Perceptions of Mental Health Nurses Regarding Metabolic Syndrome at a
   Public Tertiary Psychiatric Hospital in Western Cape, South Africa
SO AFRICAN JOURNAL OF NURSING AND MIDWIFERY
LA English
DT Article
DE mental health; metabolic syndrome; severe mental illness; specialised
   mental health nurse; professional nurse
ID NONCOMMUNICABLE DISEASES; PREVALENCE; PEOPLE; RISK; CARE; ATTITUDES;
   ILLNESS
AB Mental and physical health should not be regarded as two separate entities. Recognising the periodic co-morbidity between mental and physical health conditions could facilitate an improvement in the observed lack of screening for metabolic syndrome (MetS) in patients with severe mental illness (SMI). The aim of the current study was to investigate the perceptions of mental health nurses about their knowledge, attitudes and practices regarding mental health care users (MCHUs) with MetS in a public tertiary psychiatric hospital. The study was conducted in one of the four public, tertiary psychiatric hospitals in Western Cape, South Africa. A self-administered quantitative descriptive survey design, using an 18-item modified version of the MBACK-Questionnaire was conducted with an all-inclusive sample of 97 mental health nurses. Ethics approval was obtained from the Western Cape Department of Health and the Research Ethics Committee from the University of Western Cape. A response rate of 87.6% (n = 85) was attained. The specialised mental health nurses reported perceived higher knowledge scores than the non-specialised mental health nurses, with no significant differences between the responses of their level of agreement for their attitudes and self-reported practices on the topic. The specialised mental health nurses perceived themselves to have better knowledge than the non-specialised mental health nurses, with both categories exhibiting similar positive attitudes towards providing general physical care and active involvement in their practice towards mental health care users (MHCUs) with MetS.
C1 [Cloete, Shoemeney A.; Daniels, Felicity M.] Univ Western Cape, Bellville, South Africa.
C3 University of the Western Cape
RP Cloete, SA (corresponding author), Univ Western Cape, Bellville, South Africa.
EM 3770003@myuwc.ac.za; fdaniels@uwc.ac.za
CR Alshehri AM, 2010, J FAM COMMUNITY MED, V17, P73, DOI 10.4103/1319-1683.71987
   Beales PF, 2000, T ROY SOC TROP MED H, V94, pS1
   Boggs G R., 2011, The American Community College, V16, P2, DOI [DOI 10.1002/ABC.20055, 10.1002/j.2051-5545.2011.tb00014.x]
   Bolton PS, 2016, J PSYCHOSOC NURS MEN, V54, P44, DOI 10.3928/02793695-20161026-01
   Bressington D, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15020343
   Bressington DT, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-87
   Bressington Daniel T, 2013, BMC PSYCHIATRY, V13, DOI [10.1186/1471-244X-13-87, DOI 10.1186/1471-244X-13-87]
   Cyrus S.H., 2014, Advances in Psychiatric Treatment, V20, P101, DOI 10.1192/apt.bp.113.011619
   Dayabandara M, 2017, NEUROPSYCH DIS TREAT, V13, DOI 10.2147/NDT.S113099
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   Erasmus RT, 2012, SAMJ S AFR MED J, V102, P841, DOI [10.7196/SAMJ.5670, 10.7196/samj.5670]
   Esmailnasab N, 2012, IRAN J PUBLIC HEALTH, V41, P77
   Faasen N, 2014, SAJP-S AFR J PSYCHI, V20, P54, DOI 10.7196/SAJP.528
   Ganiah AN, 2017, COMMUNITY MENT HLT J, V53, P725, DOI 10.1007/s10597-017-0143-6
   Giandinoto Jo-Ann, 2015, BMC Res Notes, V8, P295, DOI 10.1186/s13104-015-1264-z
   Happell B, 2016, BMC PSYCHIATRY, V16, DOI 10.1186/s12888-016-0814-9
   Hofman K, 2014, SAMJ S AFR MED J, V104, P647, DOI [10.7196/samj.8727, 10.7196/SAMJ.8727]
   Kruger MJ, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-016-3973-1
   Maaroganye K, 2013, AFR J PSYCHIATRY, V16, P414, DOI [10.4314/ajpsy.v16i6.53, http://dx.doi.org/10.4314/ajpsy.v16i6.53]
   McInnis Angie, 2021, Management, V26, DOI [10.3912/OJIN.Vol26No01Man05, DOI 10.1080/026725, DOI https://doi.org/10.1080/07391102.2019.1708797]
   Mitchell AJ, 2012, PSYCHOL MED, V42, P125, DOI 10.1017/S003329171100105X
   Mitchell AJ, 2015, GEN HOSP PSYCHIAT, V37, P14, DOI 10.1016/j.genhosppsych.2014.11.006
   Mone Pasquale, 2021, CANCERS, V7, P9, DOI [10.3390/ncrna7010009, DOI 10.3390/CANCERS12040976]
   NDoH (National Department of Health), 2016, STRAT PREV CONTR OB
   Okafor Christian I, 2012, Indian J Endocrinol Metab, V16, P56, DOI 10.4103/2230-8210.91191
   Papanastasiou E, 2012, THER ADV ENDOCRINOL, V3, P141, DOI 10.1177/2042018812458697
   Papanastasiou Evangelos, 2012, SCAND J PUBLIC HEALT, V3, P141, DOI [10.1177/1087057115623264, DOI https://doi.org/10.1177/1077558703259096, 10.1177/2042018812458697, DOI 10.1177/1403494821993714]
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Robson D, 2013, INT J MENT HEALTH NU, V22, P409, DOI 10.1111/j.1447-0349.2012.00883.x
   Robson Debbie, 2012, TRAFFIC, V22, P409, DOI [10.1111/j.1447-0349.2012.00883.x, DOI 10.1111/J.1600-0854.2008.00835.X]
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Saloojee S, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0149209
   Schacht C.A., 2004, Refractories Handbook, DOI [10.1201/9780203026328, 10.1016/j.tibs.2012.12.006, DOI 10.1201/9780203026328]
   Sit J.W. H., 2014, International Journal of Sciences: Basic and Applied Research, V13, P119
   Steinberg G, 2015, J OCCUP ENVIRON MED, V57, P1269, DOI 10.1097/JOM.0000000000000582
   Watkins A, 2017, FRONT PUBLIC HEALTH, V5, DOI 10.3389/fpubh.2017.00321
NR 36
TC 0
Z9 0
U1 0
U2 0
PU UNISA PRESS
PI PRETORIA
PA PO BOX 392, PRETORIA, 0003, SOUTH AFRICA
SN 1682-5055
J9 AFR J NURS MIDWIFERY
JI Afr. J. Nurs. Midwifery
PY 2022
VL 24
IS 1
AR 9469
DI 10.25159/2520-5293/9469
PG 13
WC Nursing
WE Emerging Sources Citation Index (ESCI)
SC Nursing
GA F1RY1
UT WOS:000980200400011
OA Bronze
DA 2025-06-11
ER

PT J
AU Sasaki, A
   de Vega, W
   Sivanathan, S
   St-Cyr, S
   McGowan, PO
AF Sasaki, A.
   de Vega, W.
   Sivanathan, S.
   St-Cyr, S.
   McGowan, P. O.
TI MATERNAL HIGH-FAT DIET ALTERS ANXIETY BEHAVIOR AND GLUCOCORTICOID
   SIGNALING IN ADOLESCENT OFFSPRING
SO NEUROSCIENCE
LA English
DT Article
DE glucocorticoid receptor; inflammatory; anxiety behavior; maternal;
   obesity; gene expression programming
ID MECHANISMS LINKING OBESITY; PITUITARY-ADRENAL AXIS; FEMALE RATS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; STRESS RESPONSES; PRENATAL
   STRESS; MILD STRESS; PREGNANCY; ADULTHOOD
AB Maternal obesity and overconsumption of saturated fats during pregnancy have profound effects on offspring health, ranging from metabolic to behavioral disorders in later life. The influence of high-fat diet (HFD) exposure on the development of brain regions implicated in anxiety behavior is not well understood. We previously found that maternal HFD exposure is associated with an increase in anxiety behavior and alterations in the expression of several genes involved in inflammation via the glucocorticoid signaling pathway in adult rat offspring. During adolescence, the maturation of feedback systems mediating corticosteroid sensitivity is incomplete, and therefore distinct from adulthood. In this study, we examined the influence of maternal HFD on several measures of anxiety behavior and gene expression in adolescent offspring. We examined the expression of corticosteroid receptors and related inflammatory processes, as corticosteroid receptors are known to regulate circulating corticosterone levels during basal and stress conditions in addition to influencing inflammatory processes in the hippocampus and amygdala. We found that adolescent animals perinatally exposed to HFD generally showed decreased anxiety behavior accompanied by a selective alteration in the expression of the glucocorticoid receptor and several downstream inflammatory genes in the hippocampus and amygdala. These data suggest that adolescence constitutes an additional period when the effects of developmental programming may modify mental health trajectories. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
C1 Univ Toronto, Dept Biol Sci, Ctr Environm Epigenet & Dev, Toronto, ON M1C 1A4, Canada.
   Univ Toronto, Dept Cell & Syst Biol, Toronto, ON M1C 1A4, Canada.
C3 University of Toronto; University of Toronto
RP McGowan, PO (corresponding author), Univ Toronto, Dept Biol Sci, Room SW548,1265 Mil Trail, Toronto, ON M1C 1A4, Canada.
EM patrick.mcgowan@utoronto.ca
FU Natural Sciences and Engineering Research Council of Canada (NSERC)
FX This work was supported by an operating grant from the Natural Sciences
   and Engineering Research Council of Canada (NSERC) to P.O.M.
CR Almeida SS, 1996, PHYSIOL BEHAV, V60, P675, DOI 10.1016/S0031-9384(96)80047-3
   Arborelius L, 1999, J ENDOCRINOL, V160, P1, DOI 10.1677/joe.0.1600001
   Bersamin A, 2008, J AM DIET ASSOC, V108, P266, DOI 10.1016/j.jada.2007.10.046
   Bilbo SD, 2010, FASEB J, V24, P2104, DOI 10.1096/fj.09-144014
   Boksa P, 2004, BRAIN RES REV, V45, P1, DOI 10.1016/j.brainresrev.2004.01.001
   Boney CM, 2005, PEDIATRICS, V115, pE290, DOI 10.1542/peds.2004-1808
   Bostic Jeff Q, 2005, J Psychiatr Pract, V11, P141, DOI 10.1097/00131746-200505000-00002
   Brunton PJ, 2010, J NEUROENDOCRINOL, V22, P1198, DOI 10.1111/j.1365-2826.2010.02067.x
   Cabanes A, 2000, DEV NEUROSCI-BASEL, V22, P488, DOI 10.1159/000017480
   Catalano PM, 2007, OBSTET GYNECOL, V109, P419, DOI 10.1097/01.AOG.0000253311.44696.85
   Colorado RA, 2006, BEHAV PROCESS, V71, P51, DOI 10.1016/j.beproc.2005.09.007
   De Souza CT, 2005, ENDOCRINOLOGY, V146, P4192, DOI 10.1210/en.2004-1520
   Desai RA, 2009, CNS SPECTRUMS, V14, P372, DOI 10.1017/S1092852900023026
   Dunn GA, 2009, ENDOCRINOLOGY, V150, P4999, DOI 10.1210/en.2009-0500
   El-Haschimi K, 2000, J CLIN INVEST, V105, P1827, DOI 10.1172/JCI9842
   Godfrey KM, 2010, TRENDS ENDOCRIN MET, V21, P199, DOI 10.1016/j.tem.2009.12.008
   Groeneweg FL, 2011, J ENDOCRINOL, V209, P153, DOI 10.1530/JOE-10-0472
   HilakiviClarke L, 1995, ANN NY ACAD SCI, V768, P327, DOI 10.1111/j.1749-6632.1995.tb12152.x
   Jacobson-Pick S, 2011, BEHAV BRAIN RES, V216, P365, DOI 10.1016/j.bbr.2010.08.016
   Jacobson-Pick S, 2010, BEHAV BRAIN RES, V214, P268, DOI 10.1016/j.bbr.2010.05.036
   Kahn SE, 2006, NATURE, V444, P840, DOI 10.1038/nature05482
   Legendre A, 2006, AM J PHYSIOL-REG I, V291, pR1288, DOI 10.1152/ajpregu.00234.2006
   Llaneza DC, 2009, PHARMACOL BIOCHEM BE, V93, P337, DOI 10.1016/j.pbb.2009.05.003
   Loram LC, 2012, PSYCHONEUROENDOCRINO, V37, P1688, DOI 10.1016/j.psyneuen.2012.02.018
   Marx J, 2002, SCIENCE, V296, P686, DOI 10.1126/science.296.5568.686
   McCormick CM, 2008, BEHAV BRAIN RES, V187, P228, DOI 10.1016/j.bbr.2007.09.005
   McCormick CM, 2013, NEUROSCIENCE, V249, P242, DOI 10.1016/j.neuroscience.2012.08.063
   McGowan PO, 2008, BRAIN RES, V1237, P12, DOI 10.1016/j.brainres.2008.07.074
   Meaney MJ, 2001, ANNU REV NEUROSCI, V24, P1161, DOI 10.1146/annurev.neuro.24.1.1161
   Munhoz CD, 2010, J NEUROSCI, V30, P13690, DOI 10.1523/JNEUROSCI.0303-09.2010
   Paxinos G., 1998, RAT BRAIN STEROTAXIC, VFourth
   Peleg-Raibstein D, 2012, BEHAV BRAIN RES, V233, P398, DOI 10.1016/j.bbr.2012.05.027
   Pine DS, 1998, ARCH GEN PSYCHIAT, V55, P56, DOI 10.1001/archpsyc.55.1.56
   Proulx K, 2001, ENDOCRINOLOGY, V142, P4607, DOI 10.1210/en.142.11.4607
   Purcell RH, 2011, PHYSIOL BEHAV, V104, P474, DOI 10.1016/j.physbeh.2011.05.012
   Pyter LM, 2013, BRAIN BEHAV IMMUN, V30, P88, DOI 10.1016/j.bbi.2013.01.075
   Robbins TW, 2002, PSYCHOPHARMACOLOGY, V163, P362, DOI 10.1007/s00213-002-1154-7
   Rofey DL, 2009, CHILD PSYCHIAT HUM D, V40, P517, DOI 10.1007/s10578-009-0141-1
   Sasaki A, 2013, NEUROSCIENCE, V240, P1, DOI 10.1016/j.neuroscience.2013.02.044
   Smoak KA, 2004, MECH AGEING DEV, V125, P697, DOI 10.1016/j.mad.2004.06.010
   Sorrells SF, 2009, NEURON, V64, P33, DOI 10.1016/j.neuron.2009.09.032
   Spear LP, 2000, NEUROSCI BIOBEHAV R, V24, P417, DOI 10.1016/S0149-7634(00)00014-2
   Stein MB, 2001, ARCH GEN PSYCHIAT, V58, P251, DOI 10.1001/archpsyc.58.3.251
   Sullivan EL, 2010, J NEUROSCI, V30, P3826, DOI 10.1523/JNEUROSCI.5560-09.2010
   Tamashiro KLK, 2009, DIABETES, V58, P1116, DOI 10.2337/db08-1129
   Tannenbaum BM, 1997, AM J PHYSIOL-ENDOC M, V273, pE1168, DOI 10.1152/ajpendo.1997.273.6.E1168
   Tirelli E, 2003, NEUROSCI BIOBEHAV R, V27, P163, DOI 10.1016/S0149-7634(03)00018-6
   Van Gaal LF, 2006, NATURE, V444, P875, DOI 10.1038/nature05487
   Vázquez DM, 1998, PSYCHONEUROENDOCRINO, V23, P663
   Walker AK, 2009, PSYCHONEUROENDOCRINO, V34, P1515, DOI 10.1016/j.psyneuen.2009.05.010
   Walker CD, 2010, DEV PSYCHOBIOL, V52, P638, DOI 10.1002/dev.20492
   Weiss R, 2004, NEW ENGL J MED, V350, P2362, DOI 10.1056/NEJMoa031049
   Welberg LAM, 2001, J NEUROENDOCRINOL, V13, P113, DOI 10.1046/j.1365-2826.2001.00601.x
   Whitaker RC, 2004, PEDIATRICS, V114, pE29, DOI 10.1542/peds.114.1.e29
   White CL, 2009, NEUROBIOL DIS, V35, P3, DOI 10.1016/j.nbd.2009.04.002
   Zeidan MA, 2011, BIOL PSYCHIAT, V70, P920, DOI 10.1016/j.biopsych.2011.05.016
NR 56
TC 89
Z9 104
U1 1
U2 27
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
EI 1873-7544
J9 NEUROSCIENCE
JI Neuroscience
PD JUL 11
PY 2014
VL 272
BP 92
EP 101
DI 10.1016/j.neuroscience.2014.04.012
PG 10
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA AJ0IY
UT WOS:000337335400010
PM 24791714
DA 2025-06-11
ER

PT J
AU Mayolas-Pi, C
   Sitko, S
   Oviedo-Caro, MA
   Bueno-Antequera, J
   Reverter-Masià, J
   Francín-Gallego, M
   Sarasa-Oliván, FJ
   Legaz-Arrese, A
AF Mayolas-Pi, C.
   Sitko, S.
   Oviedo-Caro, M. A.
   Bueno-Antequera, J.
   Reverter-Masia, J.
   Francin-Gallego, M.
   Sarasa-Olivan, F. J.
   Legaz-Arrese, A.
TI Influence of organised sports practice during adolescence on health of
   adult women with special emphasis on participation in aesthetic sports
SO EUROPEAN JOURNAL OF SPORT SCIENCE
LA English
DT Article
DE Physical activity; aesthetic sports; psychosocial health; quality of
   life; cardiometabolic risk
ID PHYSICAL-ACTIVITY; BODY DISSATISFACTION; SLEEP; DEPRESSION; CHILDHOOD;
   ASSOCIATIONS; RELIABILITY; PERFORMANCE; PREVALENCE; VALIDATION
AB This study aimed to assess the differences in psychosocial health and cardiometabolic risk during adulthood in women based on previously organised sport (OS) participation during adolescence and current activity levels, with emphasis on participation in aesthetic sports. The study included 1947 women aged 18-55 years who were categorised into four groups: 355 aesthetic athletes during adolescence, 494 non- aesthetic athletes during adolescence, 791 non-athletes during adolescence with similar current levels of physical activity (PA) to OS groups and 307 currently inactive non-athletes during adolescence. Participants answered questionnaires regarding sport participation, psychosocial health and cardiometabolic risk. The results show that non-athletes during adolescence who are currently inactive reported significantly lower psychosocial health and higher cardiometabolic risk scores. Women with currently homogenous PA levels (chi(2) = 0.514) reported similar physical quality of life (QoL), exercise addiction, anxiety and depression symptoms regardless of participation in OS during adolescence (P > .05), except aesthetic athletes who reported the worst sleep and mental QoL. Very high training volumes in aesthetic athletes did not influence psychological outcomes and cardiometabolic risk in adulthood compared to lower training volumes. In conclusion, the effects of PA during adulthood appear to be powerful enough to induce beneficial adaptations in health outcomes that match those observed in women who participate in OS during adolescence, except for aesthetic sports participants, who show a high risk of lower quality of sleep in adulthood. PA should be promoted in adults and especially women who have not participated in OS during adolescence.
C1 [Mayolas-Pi, C.; Legaz-Arrese, A.] Univ Zaragoza, Fac Hlth & Sport Sci, Sect Phys Educ & Sports, Zaragoza, Spain.
   [Mayolas-Pi, C.; Sitko, S.; Legaz-Arrese, A.] Univ Zaragoza, Fac Hlth & Sport Sci, Zaragoza, Spain.
   [Mayolas-Pi, C.; Sitko, S.; Oviedo-Caro, M. A.; Bueno-Antequera, J.; Reverter-Masia, J.; Francin-Gallego, M.; Sarasa-Olivan, F. J.; Legaz-Arrese, A.] Univ Zaragoza, Res Grp Movimiento Humano, Zaragoza, Spain.
   [Oviedo-Caro, M. A.; Bueno-Antequera, J.] Univ Pablo de Olavide, Fac Sports Sci, Phys Performance & Sports Res Ctr, Dept Sports & Comp Sci,Sect Phys Educ & Sports, Seville, Spain.
   [Reverter-Masia, J.] Univ Lleida, Sect Phys Educ & Sports, Fac Educ Psychol & Social Work, Lleida, Spain.
   [Francin-Gallego, M.] Univ San Jorge, Hlth Sci Fac, Campus Univ Villanueva de Gallego, Villanueva De Gallego, Spain.
   [Sarasa-Olivan, F. J.] Med Ctr Sports Med, Podium, Zaragoza, Spain.
C3 University of Zaragoza; University of Zaragoza; University of Zaragoza;
   Universidad Pablo de Olavide; Universitat de Lleida; Universidad San
   Jorge
RP Sitko, S (corresponding author), Univ Zaragoza, Calle Domingo Miral S-N, E-50009 Zaragoza, Spain.
EM 685492@unizar.es
RI Reverter-Masia, Joaquin/H-5725-2012; Mayolas-Pi, Carmen/Y-2652-2018;
   Oviedo-Caro, Miguel/AAT-6933-2020; Sitko, Sebastian/AAD-6806-2020;
   Bueno-Antequera, Javier/H-5515-2015
OI Mayolas Pi, Carmen/0000-0003-0721-2447; FRANCIN GALLEGO,
   MARINA/0000-0001-9139-5834; Oviedo-Caro, Miguel
   Angel/0000-0003-1032-0529; Bueno-Antequera, Javier/0000-0001-8063-3980
FU University of Zaragoza, Spain [UZ2016-BIO-03]; Government of Aragon
   through the European Fund of Regional Development-Operative program
   FEDER Aragon 2014-2020 "Construyendo Europa desde Aragon" [S25-D17,
   PUI/2018337, PUI/2018-336]; Spanish Ministry of Education [FPU13/05130];
   Universidad de Lleida, Catedra ASISA [X18010]
FX This work was supported by the University of Zaragoza, Spain (Grant
   Number UZ2016-BIO-03), and the Government of Aragon (Grant Number
   S25-D17) through the European Fund of Regional Development-Operative
   program FEDER Aragon 2014-2020 "Construyendo Europa desde Aragon". JBA
   was supported by the Spanish Ministry of Education (Grant Number
   FPU13/05130). JBA and MAOC were supported by the Government of Aragon
   through the European Fund of Regional Development-Operative program
   FEDER Aragon 2014-2020 "Construyendo Europa desde Aragon" (grant numbers
   PUI/2018337 (JBA) and PUI/2018-336 (MAOC)). JRM was supported by
   Universidad de Lleida, Catedra ASISA (Grant Number X18010).
CR Abbott BD, 2011, PSYCHOL SPORT EXERC, V12, P333, DOI 10.1016/j.psychsport.2010.10.005
   Bar RJ, 2016, EUR J SPORT SCI, V16, P325, DOI 10.1080/17461391.2015.1013995
   Brand S, 2017, J SPORT SCI, V35, P426, DOI 10.1080/02640414.2016.1167936
   Chaput JP, 2016, APPL PHYSIOL NUTR ME, V41, pS266, DOI 10.1139/apnm-2015-0627
   Cohen A, 2016, J AGING PHYS ACTIV, V24, P32, DOI 10.1123/japa.2014-0169
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   de Bruin AP, 2007, PSYCHOL SPORT EXERC, V8, P507, DOI 10.1016/j.psychsport.2006.10.002
   de Souza MC, 2017, ANN HUM BIOL, V44, P11, DOI 10.3109/03014460.2016.1165866
   Fernandes RA, 2010, HYPERTENS RES, V33, P926, DOI 10.1038/hr.2010.106
   Herman KM, 2010, QUAL LIFE RES, V19, P339, DOI 10.1007/s11136-010-9586-8
   Herrero MJ, 2003, GEN HOSP PSYCHIAT, V25, P277, DOI 10.1016/S0163-8343(03)00043-4
   Hita-Contreras F, 2014, RHEUMATOL INT, V34, P929, DOI 10.1007/s00296-014-2960-z
   Howie EK, 2016, MED SCI SPORT EXER, V48, P1331, DOI 10.1249/MSS.0000000000000894
   Jewett R, 2014, J ADOLESCENT HEALTH, V55, P640, DOI 10.1016/j.jadohealth.2014.04.018
   Korte KJ, 2013, ADDICT BEHAV, V38, P1757, DOI 10.1016/j.addbeh.2012.10.013
   Krentz EM, 2013, SCAND J MED SCI SPOR, V23, P303, DOI 10.1111/j.1600-0838.2011.01380.x
   Kuula L, 2016, J PEDIATR-US, V177, P173, DOI 10.1016/j.jpeds.2016.06.026
   Lanfranchi MC, 2014, SCAND J MED SCI SPOR, V24, P622, DOI 10.1111/sms.12044
   Lang C, 2016, SLEEP MED REV, V28, P32, DOI 10.1016/j.smrv.2015.07.004
   LaPrade RF, 2016, ORTHOP J SPORTS MED, V4, DOI 10.1177/2325967116644241
   Logan K, 2019, PEDIATRICS, V143, DOI 10.1542/peds.2019-0997
   Lombardo C, 2012, EAT WEIGHT DISORD-ST, V17, pE116, DOI 10.1007/BF03325335
   Marques A, 2016, J SCI MED SPORT, V19, P154, DOI 10.1016/j.jsams.2015.02.007
   McDowell CP, 2017, J ADOLESCENCE, V55, P1, DOI 10.1016/j.adolescence.2016.12.004
   McMahon EM, 2017, EUR CHILD ADOLES PSY, V26, P111, DOI 10.1007/s00787-016-0875-9
   McPhie ML, 2015, J ADOLESCENCE, V40, P83, DOI 10.1016/j.adolescence.2015.01.008
   Merglen A, 2014, ARCH DIS CHILD, V99, P208, DOI 10.1136/archdischild-2013-303729
   Munguia-Izquierdo D, 2017, J PHYS ACT HEALTH, V14, P876, DOI 10.1123/jpah.2017-0010
   Neves CM, 2017, J SPORT SCI, V35, P1745, DOI 10.1080/02640414.2016.1235794
   Ortega FB, 2011, INT J EPIDEMIOL, V40, P701, DOI 10.1093/ije/dyr039
   Sabiston CM, 2016, J SPORT EXERCISE PSY, V38, P105, DOI 10.1123/jsep.2015-0175
   Schaal K, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019007
   Schröder H, 2011, J NUTR, V141, P1140, DOI 10.3945/jn.110.135566
   Sicilia A, 2013, PSICOTHEMA, V25, P377, DOI 10.7334/psicothema2013.21
   Sigvartsen J, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-3407-0
   Silva MRG, 2016, EUR J SPORT SCI, V16, P726, DOI 10.1080/17461391.2015.1103316
   Stockwell T., 2000, International Guide for Monitoring Alcohol Consumption and Harm
   Sundgot-Borgen J, 2012, MED SCI SPORT EXER, V44, P703
   Telama R, 2014, MED SCI SPORT EXER, V46, P955, DOI 10.1249/MSS.0000000000000181
   Vilagut G, 2008, MED CLIN-BARCELONA, V130, P726, DOI 10.1157/13121076
   World Health Organization, 2019, World Health Organization
   Zhang JH, 2016, SLEEP, V39, P1563, DOI 10.5665/sleep.6022
NR 42
TC 5
Z9 5
U1 4
U2 26
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1746-1391
EI 1536-7290
J9 EUR J SPORT SCI
JI Eur. J. Sport Sci.
PD JAN 2
PY 2021
VL 21
IS 1
BP 107
EP 117
DI 10.1080/17461391.2020.1736180
EA MAR 2020
PG 11
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Sport Sciences
GA PS8CK
UT WOS:000524702300001
PM 32101509
DA 2025-06-11
ER

PT J
AU Goldman, N
   Glei, DA
   Seplaki, C
   Liu, IW
   Weinstein, M
AF Goldman, N
   Glei, DA
   Seplaki, C
   Liu, IW
   Weinstein, M
TI Perceived stress and physiological dysregulation in older adults
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Article
DE aging; allostatic load; biomarkers; perceived stress; physiological
   dysregulation; physiological parameters
ID METABOLIC SYNDROME-X; ALLOSTATIC LOAD; BLOOD-PRESSURE;
   DEHYDROEPIANDROSTERONE-SULFATE; SEX-DIFFERENCES; CARDIOVASCULAR-DISEASE;
   PSYCHOLOGICAL STRESS; RISK-FACTORS; LIFE EVENTS; HEALTH
AB We use a population-based representative sample of older Taiwanese to investigate links between respondents' perceived levels of stress and a broad set of biological measures. These biomarkers were collected at a single time (2000) and reflect sympathetic nervous system (SNS)-activity, hypothalamo-pituitary-adrenal (HPA)-activity, immune function, cardiovascular function, and metabolic pathways. We model the relationship between perceived stress and (1) extreme values for each of 16 individual biological indicators; and (2) a measure of cumulative physiological dysregulation based on the full set of biomarkers. We consider two measures of perceived stress, one derived from the 2000 interview and the second based on data from three interviews (1996-2000). Age and sex-adjusted models reveal significant associations between measures of perceived stress and extreme values of cortisol, triglycerides, interleukin-6 (IL-6), dehydroepiandrosterone sulphate (DHEAS) and fasting glucose. Examined individually, numerous biomarkers, including those pertaining to blood pressure and obesity, are not significantly related to perceived stress. jointly, however, the measure of cumulative physiological clysregulation is associated with both the level of perceived stress at a given time and to a longitudinal measure of perceived stress. Some results suggest that the relationship between level of perceived stress and physiological response is stronger for women than men.
C1 Princeton Univ, Off Populat Res, Princeton, NJ 08540 USA.
   Univ Calif Berkeley, Dept Demog, Berkeley, CA 94720 USA.
   Bur Hlth Promot, Dept Hlth, Ctr Populat & Hlth Survey Res, Taichung 408, Taiwan.
   Georgetown Univ, Ctr Populat Hlth, Washington, DC 20057 USA.
C3 Princeton University; University of California System; University of
   California Berkeley; Georgetown University
RP Goldman, N (corresponding author), Princeton Univ, Off Populat Res, 243 Wallace Hall, Princeton, NJ 08544 USA.
EM ngoldman@princeton.edu
OI Goldman, Noreen/0000-0003-2865-9491; Seplaki,
   Christopher/0000-0001-8296-7714
FU NIA NIH HHS [R01AG16661, R01AG16790] Funding Source: Medline; NICHD NIH
   HHS [5P30HD32030] Funding Source: Medline
CR Anderson DE, 2002, INT J BEHAV MED, V9, P216, DOI 10.1207/S15327558IJBM0903_04
   Anisman H, 2003, ANN MED, V35, P2, DOI 10.1080/07853890310004075
   BARRETTCONNOR E, 1986, NEW ENGL J MED, V315, P1519, DOI 10.1056/NEJM198612113152405
   Bernton E, 1995, ANN NY ACAD SCI, V774, P217
   Biondi M, 1999, PSYCHOTHER PSYCHOSOM, V68, P114, DOI 10.1159/000012323
   Björntorp P, 1999, ANN NY ACAD SCI, V892, P297, DOI 10.1111/j.1749-6632.1999.tb07803.x
   Black PH, 2003, BRAIN BEHAV IMMUN, V17, P350, DOI 10.1016/S0889-1591(03)00048-5
   Black PH, 2002, J PSYCHOSOM RES, V52, P1, DOI 10.1016/S0022-3999(01)00302-6
   Brisson C, 2000, J OCCUP ENVIRON MED, V42, P40, DOI 10.1097/00043764-200001000-00011
   Caputo JL, 2000, ANN BEHAV MED, V22, P65, DOI 10.1007/BF02895169
   Carter-Snell Cathy, 2003, Can J Nurs Res, V35, P34
   Clauw DJ, 1997, NEUROIMMUNOMODULAT, V4, P134, DOI 10.1159/000097332
   Cohen S., 1997, Measuring stress: A guide for health and social scientists
   Coleman CA, 1998, ADOLESCENCE, V33, P447
   DUDLEY RA, 1985, CLIN CHEM, V31, P1264
   Geary DC, 2002, PSYCHOL REV, V109, P745, DOI 10.1037//0033-295X.109.4.745
   Glei DA, 2004, EXP GERONTOL, V39, P321, DOI 10.1016/j.exger.2003.11.003
   Gold SM, 2003, PSYCHONEUROENDOCRINO, V28, P584, DOI 10.1016/S0306-4530(02)00046-X
   Goldblatt D, 2001, NEUROLOGY, V56, P148, DOI 10.1212/WNL.56.2.148
   GOLDSTON DB, 1995, HEALTH PSYCHOL, V14, P409, DOI 10.1037/0278-6133.14.5.409
   GREEN BL, 1992, J NERV MENT DIS, V180, P750
   Heim C, 2002, DEPRESS ANXIETY, V15, P117, DOI 10.1002/da.10015
   Hermalin A.L., 1989, 1989 Survey of the Health and Living Status of the Elderly in Taiwan: Questionnaire and Survey Design
   Heslop P, 2001, BRIT J HEALTH PSYCH, V6, P167, DOI 10.1348/135910701169133
   Karlamangla AS, 2002, J CLIN EPIDEMIOL, V55, P696, DOI 10.1016/S0895-4356(02)00399-2
   Kelly S, 1997, ANNU REV PUBL HEALTH, V18, P437, DOI 10.1146/annurev.publhealth.18.1.437
   Konen J C, 1993, Arch Fam Med, V2, P393, DOI 10.1001/archfami.2.4.393
   Kristensen T S, 1996, J Occup Health Psychol, V1, P246, DOI 10.1037/1076-8998.1.3.246
   Kristenson M, 1998, INT J BEHAV MED, V5, P17, DOI 10.1207/s15327558ijbm0501_2
   Kroboth PD, 1999, J CLIN PHARMACOL, V39, P327, DOI 10.1177/00912709922007903
   Lohman TG, 1988, Anthropometric Standardization Reference Manual. Abridged Edition
   LUNDBERG U, 1981, J HUM STRESS, V7, P3, DOI 10.1080/0097840X.1981.9936826
   Macintyre S, 1999, SOC SCI MED, V48, P89, DOI 10.1016/S0277-9536(98)00292-5
   Mazat L, 2001, P NATL ACAD SCI USA, V98, P8145, DOI 10.1073/pnas.121177998
   MCEWEN BS, 1993, ARCH INTERN MED, V153, P2093, DOI 10.1001/archinte.153.18.2093
   McEwen BS, 2002, NEUROBIOL AGING, V23, P921, DOI 10.1016/S0197-4580(02)00027-1
   MIZOCK BA, 1995, AM J MED, V98, P75, DOI 10.1016/S0002-9343(99)80083-7
   Pike JL, 1997, PSYCHOSOM MED, V59, P447, DOI 10.1097/00006842-199707000-00015
   Rose G, 1998, OCCUP MED-OXFORD, V48, P329, DOI 10.1093/occmed/48.5.329
   SAMAAN GJ, 1993, CLIN BIOCHEM, V26, P153, DOI 10.1016/0009-9120(93)90019-3
   SCHNALL PL, 1992, AM J IND MED, V21, P417, DOI 10.1002/ajim.4700210314
   Schwartz J E, 1996, J Occup Health Psychol, V1, P287, DOI 10.1037/1076-8998.1.3.287
   Seeman TE, 1997, ARCH INTERN MED, V157, P2259
   Seeman TE, 2001, P NATL ACAD SCI USA, V98, P4770, DOI 10.1073/pnas.081072698
   SEPLAKI CL, 2004, 200402 OFF POP RES
   SEPLAKI CL, IN PRESS EXP GERONTO
   Shansky RM, 2004, MOL PSYCHIATR, V9, P531, DOI 10.1038/sj.mp.4001435
   Sluiter JK, 2000, SCAND J WORK ENV HEA, V26, P306, DOI 10.5271/sjweh.547
   Steptoe A, 1999, J HYPERTENS, V17, P193, DOI 10.1097/00004872-199917020-00003
   Stroud LR, 2002, BIOL PSYCHIAT, V52, P318, DOI 10.1016/S0006-3223(02)01333-1
   Suter PM, 1997, J HUM HYPERTENS, V11, P171, DOI 10.1038/sj.jhh.1000409
   Taylor SE, 2000, PSYCHOL REV, V107, P411, DOI 10.1037/0033-295X.107.3.411
   VanItallie TB, 2002, METABOLISM, V51, P1, DOI 10.1053/meta.2002.33182
   YEHUDA R, 1991, BIOL PSYCHIAT, V30, P1031, DOI 10.1016/0006-3223(91)90123-4
NR 54
TC 79
Z9 106
U1 1
U2 30
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1025-3890
J9 STRESS
JI Stress
PD JUN
PY 2005
VL 8
IS 2
BP 95
EP 105
DI 10.1080/10253890500141905
PG 11
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA 946OU
UT WOS:000230582600002
PM 16019601
OA Bronze
DA 2025-06-11
ER

PT J
AU McIntyre, RS
   Fayyad, R
   Mackell, JA
   Boucher, M
AF McIntyre, Roger S.
   Fayyad, Rana
   Mackell, Joan A.
   Boucher, Matthieu
TI Effect of metabolic syndrome and thyroid hormone on efficacy of
   desvenlafaxine 50 and 100 mg/d in major depressive disorder
SO CURRENT MEDICAL RESEARCH AND OPINION
LA English
DT Article
DE metabolic syndrome X; thyroid-stimulating hormone; comorbidity; body
   mass index; HDL cholesterol; depression; Blood pressure
ID PRETREATMENT ORTHOSTATIC HYPOTENSION; PLACEBO-CONTROLLED TRIAL;
   DOUBLE-BLIND; TREATMENT RESPONSE; GERIATRIC DEPRESSION;
   SERUM-CHOLESTEROL; BLOOD-PRESSURE; SAFETY; TOLERABILITY; SYMPTOMS
AB Objective This pooled, post hoc analysis evaluated the efficacy of desvenlafaxine vs placebo in adults with major depressive disorder (MDD) with and without metabolic syndrome, and above or at or below median baseline thyroid-stimulating hormone (TSH) levels.
   Research design and methods Patients were randomly assigned to receive desvenlafaxine 50 or 100 mg/d or placebo in nine short-term, double-blind studies. Metabolic syndrome was defined as meeting at least three of five criteria based on body mass index, triglycerides, high-density lipoprotein, fasting glucose, blood pressure, current medication, and medical history.
   Clinical trial registration NCT00072774; NCT00277823; NCT00300378; NCT00384033; NCT00798707; NCT00863798; NCT01121484; NCT00824291; NCT01432457
   Main outcome measures Treatment effects on change from baseline in 17-item Hamilton Rating Scale for Depression (HAM-D-17) total score at week 8 (last observation carried forward [LOCF]) were analyzed in four subgroups-metabolic syndrome and no metabolic syndrome, baseline TSH levels above median or at or below median-using analysis of covariance with treatment, study, and baseline in the model. Metabolic syndrome and TSH were examined as predictors of change in HAM-D-17 total score using regression analysis.
   Results The pooled analysis included 4279 patients; 971 (22.7%) patients had metabolic syndrome. In all subgroups, HAM-D-17 total scores improved significantly from baseline to week 8 (LOCF) with desvenlafaxine 50 or 100 mg/d compared with placebo (all p <= 0.006). There was no significant treatment by metabolic syndrome or by TSH interaction. Neither metabolic syndrome nor TSH above median predicted change in HAM-D-17 total scores, response (>= 50% reduction in HAM-D-17 total score), or remission (HAM-D-17 total score <= 7; all p > 0.05).
   Limitations Individual studies included in this analysis were not designed to examine the relationship between metabolic syndrome or TSH and response to desvenlafaxine treatment. Metabolic syndrome status was determined post hoc based on available baseline measures and not diagnosed at study entry. Exclusion criteria were selected to enroll medically healthy patients with a primary diagnosis of MDD (i.e., patients healthier than the general MDD population).
   Conclusions Desvenlafaxine 50 and 100 mg/d significantly improved depression compared with placebo in patients with and without metabolic syndrome, and in patients with baseline TSH above median and at or below median levels.
C1 [McIntyre, Roger S.] Univ Toronto, Toronto, ON M5T 2S8, Canada.
   [Fayyad, Rana; Mackell, Joan A.] Pfizer Inc, New York, NY USA.
   [Boucher, Matthieu] Pfizer Canada, Kirkland, PQ, Canada.
C3 University of Toronto; Pfizer; Pfizer USA; Pfizer; Pfizer Canada
RP McIntyre, RS (corresponding author), Univ Toronto, Psychiat & Pharmacol, 399 Bathurst St,MP 9-325, Toronto, ON M5T 2S8, Canada.; McIntyre, RS (corresponding author), Univ Hlth Network, Mood Disorders Psychopharmacol Unit, 399 Bathurst St,MP 9-325, Toronto, ON M5T 2S8, Canada.; Boucher, M (corresponding author), Pfizer Canada Inc, Med Affairs, 17300 Transcanada Highway, Kirkland, PQ H9J 2M5, Canada.
EM roger.mcintyre@uhn.ca; matthieu.boucher@pfizer.com
RI McIntyre, Roger/AAU-1000-2020; Boucher, Matthieu/AAV-2538-2021
OI Boucher, Matthieu/0000-0002-4066-0009
FU Pfizer Inc.
FX This study was sponsored by Pfizer Inc.
CR Abulseoud OA, 2013, BRAIN BEHAV, V3, P89, DOI 10.1002/brb3.109
   Akbaraly TN, 2009, DIABETES CARE, V32, P499, DOI 10.2337/dc08-1358
   Almeida-Montes LG, 2000, J PSYCHIATR NEUROSCI, V25, P371
   Alvarez W, 2003, PHARMACOTHERAPY, V23, P754, DOI 10.1592/phco.23.6.754.32185
   American Psychiatric Association, 2000, spectrum disorders using the current DSM-IV-TR diagnostic, V4th, DOI 10.1176/dsm10.1176/appi.books.9780890420249.dsm-iv-tr
   Machado RA, 2010, EPILEPSY BEHAV, V19, P509, DOI 10.1016/j.yebeh.2010.06.045
   Baek JH, 2014, PROG NEURO-PSYCHOPH, V51, P113, DOI 10.1016/j.pnpbp.2014.01.018
   Boyer P, 2008, INT CLIN PSYCHOPHARM, V23, P243, DOI 10.1097/YIC.0b013e32830cebed
   Brouwer JP, 2005, EUR J ENDOCRINOL, V152, P185, DOI 10.1530/eje.1.01828
   Clayton AH, 2015, J CLIN PSYCHIAT, V76, P562, DOI 10.4088/JCP.13m08978
   Clayton AH, 2013, J CLIN PSYCHIAT, V74, P1010, DOI 10.4088/JCP.12m08065
   Clayton AH, 2009, CNS SPECTRUMS, V14, P183, DOI 10.1017/S1092852900020204
   Corruble E, 2010, J AFFECT DISORDERS, V123, P312, DOI 10.1016/j.jad.2009.09.012
   Deisenhammer EA, 2004, PSYCHIAT RES, V121, P253, DOI 10.1016/j.psychres.2003.09.007
   Demartini B, 2014, J NERV MENT DIS, V202, P603, DOI 10.1097/NMD.0000000000000168
   DeMartinis NA, 2007, J CLIN PSYCHIAT, V68, P677, DOI 10.4088/JCP.v68n0504
   DIEHL DJ, 1993, J CLIN PSYCHOPHARM, V13, P189
   Dunlop BW, 2011, J CLIN PSYCHOPHARM, V31, P569, DOI 10.1097/JCP.0b013e31822c0a68
   Duntas LH, 2013, MINERVA ENDOCRINOL, V38, P365
   FRANK E, 1991, ARCH GEN PSYCHIAT, V48, P851, DOI 10.1001/archpsyc.1991.01810330075011
   Gil Katarzyna, 2006, Kardiol Pol, V64, P464
   Gitlin M, 2004, J PSYCHIATR NEUROSCI, V29, P383
   Gressier F, 2011, PSYCHIAT GENET, V21, P253, DOI 10.1097/YPG.0b013e3283457be5
   Guy W., 1976, ECDEU Assessment Manual for Psychopharmacology, Revised. US Department of Health, Education, and Welfare Publication (ADM), P76
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Heiskanen TH, 2006, J CLIN PSYCHIAT, V67, P1422, DOI 10.4088/JCP.v67n0913
   Hirschfeld RMA, 2002, J CLIN PSYCHIAT, V63, P826, DOI 10.4088/JCP.v63n0913
   Honig A, 2007, PSYCHOSOM MED, V69, P606, DOI 10.1097/PSY.0b013e31814b260d
   Iwata N, 2013, J PSYCHIATR PRACT, V19, P5, DOI 10.1097/01.pra.0000426323.59698.64
   JARVIK LF, 1983, J CLIN PSYCHOPHARM, V3, P368
   Joffe RT, 2008, CAN J PSYCHIAT, V53, P833, DOI 10.1177/070674370805301209
   Khan A, 2007, J AFFECT DISORDERS, V99, P101, DOI 10.1016/j.jad.2006.08.027
   Kloiber S, 2007, BIOL PSYCHIAT, V62, P321, DOI 10.1016/j.biopsych.2006.10.001
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178, DOI 10.4088/JCP.v69n0202
   Liebowitz MR, 2008, CURR MED RES OPIN, V24, P1877, DOI 10.1185/03007990802161923 
   Liebowitz MR, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-94
   Lin CH, 2014, J AFFECT DISORDERS, V161, P123, DOI 10.1016/j.jad.2014.02.039
   Mavrides N, 2013, DEPRESS ANXIETY, V30, P328, DOI 10.1002/da.22051
   McIntyre RS, 2012, ANN CLIN PSYCHIATRY, V24, P2
   McIntyre RS, 2013, ANN M AM PSYCH ASS 1
   Mittal VA, 2011, PSYCHIAT RES, V189, P158, DOI 10.1016/j.psychres.2011.06.006
   MONTGOMERY SA, 1979, BRIT J PSYCHIAT, V134, P382, DOI 10.1192/bjp.134.4.382
   Oskooilar N, 2009, J CLIN PSYCHIAT, V70, P1609, DOI 10.4088/JCP.09l05226blu
   Pae CU, 2009, PSYCHIAT CLIN NEUROS, V63, P305, DOI 10.1111/j.1440-1819.2009.01938.x
   Pan A, 2012, INT J OBESITY, V36, P595, DOI 10.1038/ijo.2011.111
   Papakostas GI, 2014, J CLIN PSYCHIAT, V75, P855, DOI 10.4088/JCP.13m08947
   Papakostas GI, 2005, INT J NEUROPSYCHOPH, V8, P59, DOI 10.1017/S1461145704004602
   Polyakova EO, 2008, TERAPEVT ARKH, V80, P69
   Sarchiapone M, 2001, J AFFECT DISORDERS, V62, P217, DOI 10.1016/S0165-0327(99)00200-1
   SCHNEIDER LS, 1986, J CLIN PSYCHOPHARM, V6, P172
   Septien-Velez L, 2007, INT CLIN PSYCHOPHARM, V22, P338, DOI 10.1097/YIC.0b013e3281e2c84b
   Sheehan D.V., 2000, Handbook of Psychiatric Measures, P113
   Shrivastava S, 2010, BIOCHEMISTRY-US, V49, P5426, DOI 10.1021/bi100276b
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   STACK JA, 1988, J CLIN PSYCHOPHARM, V8, P116
   Tourian KA, 2009, CLIN THER, V31, P1405, DOI 10.1016/j.clinthera.2009.07.006
   Uher R, 2009, J AFFECT DISORDERS, V118, P147, DOI 10.1016/j.jad.2009.02.013
   Vanhala M, 2009, ACTA PSYCHIAT SCAND, V119, P137, DOI 10.1111/j.1600-0447.2008.01283.x
   World Health Organization, WELLB MEAS PRIM HLTH
   Wu EL, 2013, J PSYCHOSOM RES, V74, P233, DOI 10.1016/j.jpsychores.2012.12.016
   Zimmerman M, 2004, J CLIN PSYCHIAT, V65, P163
NR 61
TC 4
Z9 4
U1 0
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0300-7995
EI 1473-4877
J9 CURR MED RES OPIN
JI Curr. Med. Res. Opin.
PD MAR 3
PY 2016
VL 32
IS 3
BP 587
EP 599
DI 10.1185/03007995.2015.1136603
PG 13
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA DE2JM
UT WOS:000370453600001
PM 26709542
DA 2025-06-11
ER

PT J
AU Elgellaie, A
   Thomas, SJ
   Kaelle, J
   Bartschi, J
   Larkin, T
AF Elgellaie, Asmahan
   Thomas, Susan J. J.
   Kaelle, Jacqueline
   Bartschi, Jessica
   Larkin, Theresa
TI Pro-inflammatory cytokines IL-1α, IL-6 and TNF-α in major depressive
   disorder: Sex-specific associations with psychological symptoms
SO EUROPEAN JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE cardiometabolic disease; interleukin 1 alpha; interleukin 6; major
   depressive disorder; psychological distress; tumour necrosis factor
   alpha
ID NECROSIS-FACTOR-ALPHA; STRESS SCALES DASS; CARDIOVASCULAR-DISEASE;
   TREATMENT RESPONSE; METABOLIC SYNDROME; IMMUNE-SYSTEM; METAANALYSIS;
   HOSTILITY; ANXIETY; MARKERS
AB The pro-inflammatory cytokines IL-1 alpha, IL-6 and TNF-alpha are associated with major depressive disorder, psychological distress, cardiovascular health and obesity. However, there is limited research that has examined multiple associations between these variables, particularly among individuals with major depressive disorder who are treatment free, in comparison with a control cohort, and including analyses of sex differences. In this study, data were analysed from 60 individuals with major depressive disorder and 60 controls, including plasma IL-1 alpha, IL-6 and TNF-alpha, adiposity measures (body mass index, waist circumference), cardiovascular health indices (blood pressure, heart rate) and psychological symptoms (depressive severity, anxiety, hostility, stress). The cytokines were compared by group and sex and correlated with measures of adiposity, cardiovascular health indices and psychological health. Plasma IL-1 alpha and IL-6 were higher in major depressive disorder group versus control, but with a sex interaction for IL-6, with this group difference only among females. TNF-alpha did not differ between groups. IL-1 alpha and IL-6 correlated with depressive severity, anxiety, hostility and stress, whereas TNF-alpha correlated only with anxiety and hostility. Psychopathology was associated with IL-1 alpha in males only and with IL-6 and TNF-alpha in females only. None of the cytokines correlated with body mass index, waist circumference, blood pressure or heart rate. The result of group by sex interaction for IL-6 and sex-specific associations between pro-inflammatory cytokines and psychometrics could be aetiologically important in depression interventions and treatments for females versus males, warranting further investigation.
C1 [Elgellaie, Asmahan; Thomas, Susan J. J.; Kaelle, Jacqueline; Bartschi, Jessica; Larkin, Theresa] Univ Wollongong, Fac Sci Med & Hlth, Grad Sch Med, Wollongong, NSW 2522, Australia.
   [Elgellaie, Asmahan; Thomas, Susan J. J.; Kaelle, Jacqueline; Bartschi, Jessica; Larkin, Theresa] Illawarra Hlth & Med Res Inst, Wollongong, NSW, Australia.
   [Kaelle, Jacqueline] Illawarra Community Mental Hlth, Wollongong, NSW, Australia.
   [Bartschi, Jessica] Univ Wollongong, Fac Arts Social Sci & Humanities, Sch Psychol, Wollongong, NSW, Australia.
C3 University of Wollongong; University of Wollongong; Illawarra Health &
   Medical Research Institute; University of Wollongong
RP Elgellaie, A (corresponding author), Univ Wollongong, Fac Sci Med & Hlth, Grad Sch Med, Wollongong, NSW 2522, Australia.
EM aae854@uowmail.edu.au
RI Bartschi, Jessica/AAD-6829-2020
OI Larkin, Theresa/0000-0001-5916-7276; Elgellaie,
   Asmahan/0000-0002-2223-3396
FU Illawarra Health and Medical Research Institute; Australian Government
   Research Training Program Scholarship
FX Illawarra Health and Medical Research Institute; Australian Government
   Research Training Program Scholarship
CR Al-Hakeim HK, 2015, J AFFECT DISORDERS, V182, P106, DOI 10.1016/j.jad.2015.04.044
   Bacchiega BC, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.116.005038
   Ballak DB, 2015, CYTOKINE, V75, P280, DOI 10.1016/j.cyto.2015.05.005
   Barnard DF, 2019, PSYCHONEUROENDOCRINO, V103, P203, DOI 10.1016/j.psyneuen.2019.01.026
   Beurel E, 2020, NEURON, V107, P234, DOI 10.1016/j.neuron.2020.06.002
   Bhatt S, 2023, METAB BRAIN DIS, V38, P45, DOI 10.1007/s11011-022-01095-1
   Bhatt Shvetank, 2017, Journal of Basic and Clinical Physiology and Pharmacology, V28, P101, DOI 10.1515/jbcpp-2016-0083
   Birur B, 2017, FRONT PSYCHIATRY, V8, DOI 10.3389/fpsyt.2017.00108
   Brambilla F, 2004, J AFFECT DISORDERS, V78, P273, DOI 10.1016/S0165-0327(02)00315-4
   Brown TA, 1997, BEHAV RES THER, V35, P79, DOI 10.1016/S0005-7967(96)00068-X
   Bürhan-cavusoglu P, 2021, BRAIN BEHAV IMMUN-HL, V14, DOI 10.1016/j.bbih.2021.100259
   Capuron L, 2009, J AFFECT DISORDERS, V119, P181, DOI 10.1016/j.jad.2009.02.017
   Cassano P, 2017, AUST NZ J PSYCHIAT, V51, P23, DOI 10.1177/0004867416652736
   Castro JP, 2003, CURR HYPERTENS REP, V5, P393, DOI 10.1007/s11906-003-0085-y
   Celano CM, 2011, CARDIOL REV, V19, P130, DOI 10.1097/CRD.0b013e31820e8106
   Cilan H, 2012, RENAL FAILURE, V34, P275, DOI 10.3109/0886022X.2011.647292
   Dahl J, 2014, PSYCHONEUROENDOCRINO, V45, P77, DOI 10.1016/j.psyneuen.2014.03.019
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   Davidson KW, 2009, AM J CARDIOL, V103, P755, DOI 10.1016/j.amjcard.2008.11.035
   Derogatis L., 1975, Brief Symptom Inventory
   Dinarello CA, 2018, IMMUNOL REV, V281, P8, DOI 10.1111/imr.12621
   Dorrance AM, 2007, VASC PHARMACOL, V47, P160, DOI 10.1016/j.vph.2007.05.007
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Elgellaie A, 2021, COMPR PSYCHONEUROEND, V6, DOI 10.1016/j.cpnec.2021.100049
   Felger JC, 2013, NEUROSCIENCE, V246, P199, DOI 10.1016/j.neuroscience.2013.04.060
   Finnell JE, 2016, NEUROBIOL STRESS, V4, P1, DOI 10.1016/j.ynstr.2016.04.001
   Friedrich M J, 2017, JAMA, V317, P1517, DOI 10.1001/jama.2017.3826
   Gao Z., 2019, Med. Nov. Technol. Devices, V4, DOI DOI 10.1016/J.MEDNTD.2019.100025
   Goldbacher EM, 2007, ANN BEHAV MED, V34, P240, DOI 10.1007/BF02874549
   Gowey MA, 2019, INT J OBESITY, V43, P615, DOI 10.1038/s41366-018-0270-3
   Hersey M, 2022, EUR J NEUROSCI, V55, P2895, DOI 10.1111/ejn.15392
   Hueston CM, 2014, PHYSIOL BEHAV, V124, P77, DOI 10.1016/j.physbeh.2013.10.035
   Karlovic D, 2012, PSYCHIAT RES, V198, P74, DOI 10.1016/j.psychres.2011.12.007
   Kessler RC, 2003, J AFFECT DISORDERS, V74, P5, DOI 10.1016/S0165-0327(02)00426-3
   Klein SL, 2016, NAT REV IMMUNOL, V16, P626, DOI 10.1038/nri.2016.90
   Köhler CA, 2017, ACTA PSYCHIAT SCAND, V135, P373, DOI 10.1111/acps.12698
   Kornstein SG, 2000, AM J PSYCHIAT, V157, P1445, DOI 10.1176/appi.ajp.157.9.1445
   Liu Y, 2012, J AFFECT DISORDERS, V139, P230, DOI 10.1016/j.jad.2011.08.003
   LOVIBOND PF, 1995, BEHAV RES THER, V33, P335, DOI 10.1016/0005-7967(94)00075-U
   Maes M, 2011, NEUROENDOCRINOL LETT, V32, P7
   McEwen BS, 2008, EUR J PHARMACOL, V583, P174, DOI 10.1016/j.ejphar.2007.11.071
   McLeod S., 2019, Social Identity Theory
   Miller GE, 2002, AM J CARDIOL, V90, P1279, DOI 10.1016/S0002-9149(02)02863-1
   Munjiza A, 2018, PSYCHIAT RES, V264, P26, DOI 10.1016/j.psychres.2018.03.072
   Nabi H, 2010, BIOL PSYCHIAT, V67, P378, DOI 10.1016/j.biopsych.2009.07.040
   O'Connor MF, 2007, AM J PHYSIOL-REG I, V293, pR145, DOI 10.1152/ajpregu.00752.2006
   Obermanns J, 2021, EUR J NEUROSCI, V53, P3476, DOI 10.1111/ejn.15205
   Ojike N, 2016, CARDIORENAL MED, V6, P198, DOI 10.1159/000443933
   Olafiranye O, 2011, Mind Brain, V2, P32
   Osimo EF, 2020, BRAIN BEHAV IMMUN, V87, P901, DOI 10.1016/j.bbi.2020.02.010
   Pittig A, 2013, INT J PSYCHOPHYSIOL, V87, P19, DOI 10.1016/j.ijpsycho.2012.10.012
   Pituch K.A. Stevens., 2015, APPL MULTIVARIATE ST, V6th, DOI 10.4324/9781315814919
   Postal M, 2016, J NEUROINFLAMM, V13, DOI 10.1186/s12974-015-0471-9
   Quitkin FM, 2002, AM J PSYCHIAT, V159, P1848, DOI 10.1176/appi.ajp.159.11.1848
   Räikkönen K, 2003, HEALTH PSYCHOL, V22, P279, DOI 10.1037/0278-6133.22.3.279
   Reichenberg A, 2001, ARCH GEN PSYCHIAT, V58, P445, DOI 10.1001/archpsyc.58.5.445
   Ridker PM, 2021, CIRC RES, V128, P1728, DOI 10.1161/CIRCRESAHA.121.319077
   Ridker PM, 2000, NEW ENGL J MED, V342, P836, DOI 10.1056/NEJM200003233421202
   Schmidt FM, 2014, J PSYCHIATR RES, V55, P29, DOI 10.1016/j.jpsychires.2014.04.021
   Seney ML, 2022, BIOL PSYCHIAT, V91, P14, DOI 10.1016/j.biopsych.2020.12.025
   Sheehan DV, 1998, J CLIN PSYCHIAT, V59, P22, DOI 10.4088/JCP.09m05305whi
   Shelton RC, 2015, J PSYCHIATR RES, V70, P91, DOI 10.1016/j.jpsychires.2015.09.001
   Simon GE, 2008, GEN HOSP PSYCHIAT, V30, P32, DOI 10.1016/j.genhosppsych.2007.09.001
   Spicer J, 1996, J PSYCHOSOM RES, V40, P359, DOI 10.1016/0022-3999(95)00546-3
   Srivastava AK, 2012, INDIAN J PHARMACOL, V44, P155, DOI 10.4103/0253-7613.93579
   Suarez EC, 2004, PSYCHONEUROENDOCRINO, V29, P1119, DOI 10.1016/j.psyneuen.2004.01.002
   Suarez EC, 2003, PSYCHOSOM MED, V65, P362, DOI 10.1097/01.PSY.0000035719.79068.2B
   Suarez EC, 1998, ANN BEHAV MED, V20, P59, DOI 10.1007/BF02884449
   Syed SA, 2018, NEURON, V99, P914, DOI 10.1016/j.neuron.2018.08.001
   Takahashi A, 2018, FRONT BEHAV NEUROSCI, V12, DOI 10.3389/fnbeh.2018.00056
   Tuglu C, 2003, PSYCHOPHARMACOLOGY, V170, P429, DOI 10.1007/s00213-003-1566-z
   Tyring S, 2006, LANCET, V367, P29, DOI 10.1016/S0140-6736(05)67763-X
   Um JY, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0029524
   Urschel K., 2015, Int J Interf Cytokine Mediat Res, V7, P9, DOI DOI 10.2147/IJICMR.S64894
   Voronov E, 2013, FRONT IMMUNOL, V4, DOI 10.3389/fimmu.2013.00177
   Wegner A, 2017, INNATE IMMUN-LONDON, V23, P432, DOI 10.1177/1753425917707026
   Wong JM, 2013, J AM HEART ASSOC, V2, DOI 10.1161/JAHA.113.000052
   Xu CJ, 2022, J TRANSL MED, V20, DOI 10.1186/s12967-022-03439-y
NR 78
TC 26
Z9 28
U1 1
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0953-816X
EI 1460-9568
J9 EUR J NEUROSCI
JI Eur. J. Neurosci.
PD JUN
PY 2023
VL 57
IS 11
BP 1913
EP 1928
DI 10.1111/ejn.15992
EA APR 2023
PG 16
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA H9HD2
UT WOS:000976817000001
PM 37070163
OA Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Lemche, AV
   Chaban, OS
   Lemche, E
AF Lemche, Alexandra V.
   Chaban, Oleg S.
   Lemche, Erwin
TI Trait anxiety but not state anxiety level associates with biomarkers for
   hypertension in the metabolic syndrome
SO PSYCHOPHYSIOLOGY
LA English
DT Article
DE Metabolic syndrome; Pulse pressure; Spielberger State-Trait Anxiety
   Inventory; Structural equation modeling; Cross-sectional design; Cohort
   studies; National sample
ID CARDIOVASCULAR RISK; INSULIN-RESISTANCE; SYMPTOMS; PRESSURE; STRESS;
   MIDDLE; BRAIN
AB Various studies link hypertension with anxiety; however, it remains unclarified if such relations are present in the metabolic syndrome (MetS). We studied cross-sectionally the interrelations of self-reported anxiety (Spielberger STAI), and MetS components in MetS patients. We investigated a nationally sampled treatment cohort for MetS with familial Type 2 diabetes risk. N=101 patients fulfilling International Diabetes Federation criteria for MetS participated. Both laboratory and nonlaboratory measures were included. Structural equation models (SEM) were adjusted. The final SEM had an R-2 = .998 with the obesity component linking to waist, BMI, and degree of adiposity, and the hypertension component linking to systolic blood pressure, pulse pressure, total cholesterol, and trait anxiety. For state anxiety, no significant regressive causal path could be estimated. SEM supports the assumption of an interaction of pulse pressure, systolic blood pressure, cholesterol metabolism, and high trait anxiety in the pathophysiology of hypertension in MetS.
C1 [Lemche, Alexandra V.] Charite, Dept Psychosomat Med, D-13353 Berlin, Germany.
   [Chaban, Oleg S.] Bogomolets Natl Med Univ, Sect Neuroses & Somatoform Disorders, Kiev, Ukraine.
   [Lemche, Erwin] Kings Coll London, Inst Psychiat, Sect Cognit Neuropsychiat, Box PO69,De Crespigny Pk, London SE5 8AF, England.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Bogomolets
   National Medical University; University of London; King's College London
RP Lemche, E (corresponding author), Kings Coll London, Inst Psychiat, Sect Cognit Neuropsychiat, Box PO69,De Crespigny Pk, London SE5 8AF, England.
EM erwin.lemche@kcl.ac.uk
RI Chaban, Oleg/ABA-8319-2020
OI Chaban, Oleg/0000-0001-9702-7629
FU National Medical University of the Ukraine, Kiev; center grant on
   "Quality of Life in Diabetes" of the Ministry of Public Health of the
   Ukraine
FX AVL acknowledges intramural funding from the National Medical University
   of the Ukraine, Kiev. OSC was supported by a center grant on "Quality of
   Life in Diabetes" of the Ministry of Public Health of the Ukraine. The
   funders had no role whatsoever in design, analyses, or manuscript
   preparation.
CR Aksoy S, 2014, J CARDIOL, V64, P194, DOI 10.1016/j.jjcc.2014.01.002
   Anderson PJ, 2001, INT J OBESITY, V25, P1782, DOI 10.1038/sj.ijo.0801837
   [Anonymous], INT J ENDOCRINOL
   [Anonymous], 2009, Global health risks: mortality and burden of disease attributable to selected major risks
   [Anonymous], J CLIN EXPT CARDIOLO
   BENTLER PM, 1979, MULTIVAR BEHAV RES, V14, P169, DOI 10.1207/s15327906mbr1402_3
   BENTLER PM, 1980, PSYCHOMETRIKA, V45, P289, DOI 10.1007/BF02293905
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   Byrd JB, 2014, CURR HYPERTENS REP, V16, DOI 10.1007/s11906-014-0486-0
   Carroll D, 2010, PSYCHOSOM MED, V72, P16, DOI 10.1097/PSY.0b013e3181c4fca1
   Chow CK, 2013, JAMA-J AM MED ASSOC, V310, P959, DOI 10.1001/jama.2013.184182
   Dinel AL, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024325
   Domanski M, 2001, HYPERTENSION, V38, P793, DOI 10.1161/hy1001.092966
   Fossum E, 2004, BLOOD PRESSURE, V13, P89, DOI 10.1080/08037050310031008
   Grassi G, 2007, NUTR METAB CARDIOVAS, V17, P473, DOI 10.1016/j.numecd.2007.01.004
   Grös DF, 2007, PSYCHOL ASSESSMENT, V19, P369, DOI 10.1037/1040-3590.19.4.369
   Guedes EP, 2013, DIABETOL METAB SYNDR, V5, DOI 10.1186/1758-5996-5-82
   Hernandez R, 2014, PREV MED, V61, P54, DOI 10.1016/j.ypmed.2013.12.032
   Hjemdahl P, 2002, CIRCULATION, V106, P2634, DOI 10.1161/01.CIR.0000041502.43564.79
   Huang CF, 2013, DIABETES CARE, V36, P1729, DOI 10.2337/dc12-1067
   Huggett RJ, 2004, HYPERTENSION, V44, P847, DOI 10.1161/01.HYP.0000147893.08533.d8
   KOPIN IJ, 1978, ANN INTERN MED, V88, P671, DOI 10.7326/0003-4819-88-5-671
   Lambert E, 2010, J HYPERTENS, V28, P543, DOI 10.1097/HJH.0b013e3283350ea4
   Lemche AV, 2014, PSYCHIAT RES, V215, P438, DOI 10.1016/j.psychres.2013.12.004
   Luppino FS, 2011, PSYCHOSOM MED, V73, P257, DOI 10.1097/PSY.0b013e31820a59c0
   Marvar PJ, 2014, BIOL PSYCHIAT, V75, P864, DOI 10.1016/j.biopsych.2013.08.024
   Murray CJL, 2013, JAMA-J AM MED ASSOC, V310, P591, DOI 10.1001/jama.2013.13805
   O'Donovan A, 2010, BRAIN BEHAV IMMUN, V24, P1074, DOI 10.1016/j.bbi.2010.03.003
   Oler JA, 2010, NATURE, V466, P864, DOI 10.1038/nature09282
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Rogers J, 2013, MOL PSYCHIATR, V18, P700, DOI 10.1038/mp.2012.152
   Rutledge T, 2002, PSYCHOSOM MED, V64, P758, DOI 10.1097/01.PSY.0000031578.42041.1C
   Szczepanska-Sadowska E, 2010, J PHYSIOL PHARMACOL, V61, P509
   Toschi-Dias E, 2013, EUR J APPL PHYSIOL, V113, P671, DOI 10.1007/s00421-012-2476-8
   Vautier S, 2004, J PERS ASSESS, V83, P167, DOI 10.1207/s15327752jpa8302_11
   Weiber R., 2010, STRUCTURAL EQUATION
   Yates KF, 2012, ARTERIOSCL THROM VAS, V32, P2060, DOI 10.1161/ATVBAHA.112.252759
   Ziegler MG, 2012, CURR HYPERTENS REP, V14, P1, DOI 10.1007/s11906-011-0243-6
NR 38
TC 9
Z9 11
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0048-5772
EI 1469-8986
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD JUN
PY 2016
VL 53
IS 6
BP 914
EP 920
DI 10.1111/psyp.12623
PG 7
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
   Psychology, Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Neurosciences & Neurology; Physiology
GA DQ1CW
UT WOS:000378939700014
PM 26841205
DA 2025-06-11
ER

PT J
AU Scavello, I
   Maseroli, E
   Cipriani, S
   Di Stasi, V
   Verde, N
   Menafra, D
   Scannerini, S
   Marchiani, S
   Rastrelli, G
   Ricca, V
   Sorbi, F
   Fambrini, M
   Petraglia, F
   Maggi, M
   Vignozzi, L
AF Scavello, I
   Maseroli, E.
   Cipriani, S.
   Di Stasi, V
   Verde, N.
   Menafra, D.
   Scannerini, S.
   Marchiani, S.
   Rastrelli, G.
   Ricca, V
   Sorbi, F.
   Fambrini, M.
   Petraglia, F.
   Maggi, M.
   Vignozzi, Linda
TI Cardiometabolic risk is unraveled by color Doppler ultrasound of the
   clitoral and uterine arteries in women consulting for sexual symptoms
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ARTERIOGENIC ERECTILE DYSFUNCTION; METABOLIC SYNDROME; CARDIOVASCULAR
   RISK; VASCULAR MODIFICATIONS; BLOOD-FLOW; INDEX FSFI; DESIRE; SCALE;
   YOUNG
AB Female sexual dysfunction (FSD) may be a mirror of a poor cardiometabolic state. In a small pilot study enrolling 71 women with FSD, we previously demonstrated that clitoral Pulsatility Index (PI) evaluated by using color Doppler ultrasound (CDU), reflecting vascular resistance, was associated with cardiometabolic risk factors. Data on uterine CDU in this context are lacking. First, to confirm previously reported data on the direct association between clitoral PI and cardiometabolic risk factors on a larger study population of women consulting for sexual symptoms; second, to investigate eventual similar correlations between cardiometabolic risk factors and CDU parameters of the uterine artery. We also ascertained whether uterine artery PI, similarly to what had previously been observed for clitoral artery PI, was directly related to body image uneasiness and psychopathological symptoms, assessed by validated questionnaires. N = 230 women consulting our clinic for sexual symptoms were examined with clitoral CDU and blood sampling and were asked to fill out the Female Sexual Function Index, the Middlesex Hospital Questionnaire (MHQ) and the Body Uneasiness Test (BUT). In a subgroup of women (n = 164), we also performed transvaginal CDU with measurement of uterine artery parameters. At multivariate analysis, we found a direct association between clitoral PI and body mass index (BMI) (p = 0.004), waist circumference (WC) (p = 0.004), triglycerides (p = 0.006), insulin (p = 0.029) and HOMA-IR (p = 0.009). Furthermore, a correlation between obesity and Metabolic Syndrome (MetS) and a higher clitoral PI was observed (p = 0.003 and p = 0.012, respectively). Clitoral PI was also correlated with MHQ-S (p = 0.010), a scale exploring somatized anxiety symptoms, and BUT-B Positive Symptom Distress Index (p = 0.010), a measure of body image concerns. Similarly, when investigating the uterine artery, we were able to demonstrate an association between its PI and BMI (p < 0.0001), WC (p = 0.001), insulin (p = 0.006), glycated haemoglobin (p = < 0.0001), and HOMA-IR (p = 0.009). Women diagnosed with obesity and MetS showed significantly higher uterine PI values vs. those without obesity or MetS (p = 0.001 and p = 0.004, respectively). Finally, uterine PI was associated with BUT-A Global Severity Index (p < 0.0001) and with several other BUT-A subdomains. Vascular resistance of clitoral and uterine arteries is associated with cardiometabolic risk factors and body image concerns in women consulting for sexual symptoms. If further confirmed in different populations, our data could suggest CDU, a common examination method, as a useful tool for an identification-and possible correction-of cardiometabolic risk factors.
C1 [Scavello, I; Cipriani, S.; Di Stasi, V; Rastrelli, G.; Vignozzi, Linda] Univ Florence, Dept Expt Clin & Biomed Sci Mario Serio, Viale Pieraccini 6, I-50134 Florence, Italy.
   [Maseroli, E.; Rastrelli, G.; Vignozzi, Linda] Azienda Osped Univ Careggi, Androl Womens Endocrinol & Gender Incongruence Un, Florence, Italy.
   [Verde, N.; Menafra, D.] Federico II Univ Naples, Clin Med & Surg Dept, Sect Endocrinol, Unit Androl Reprod Med & Male & Female Sexual FER, Naples, Italy.
   [Scannerini, S.; Ricca, V] Univ Florence, Psychiat Unit, Dept Neurosci Psychol Drug Res & Child Hlth, Florence, Italy.
   [Marchiani, S.] Univ Florence, Dept Expt & Clin Med, Florence, Italy.
   [Sorbi, F.; Fambrini, M.; Petraglia, F.] Univ Florence, Dept Biomed Expt & Clin Sci Mario Serio, Gynecol Unit, Florence, Italy.
   [Maggi, M.] Univ Florence, Dept Expt Clin & Biomed Sci Mario Serio, Endocrinol Unit, Florence, Italy.
C3 University of Florence; University of Florence; Azienda Ospedaliero
   Universitaria Careggi; University of Naples Federico II; University of
   Florence; University of Florence; University of Florence; University of
   Florence
RP Vignozzi, L (corresponding author), Univ Florence, Dept Expt Clin & Biomed Sci Mario Serio, Viale Pieraccini 6, I-50134 Florence, Italy.; Vignozzi, L (corresponding author), Azienda Osped Univ Careggi, Androl Womens Endocrinol & Gender Incongruence Un, Florence, Italy.
EM linda.vignozzi@unifi.it
RI ricca, valdo/K-8382-2012; Menafra, Davide/AIE-4129-2022; Marchiani,
   Sara/H-9002-2018; Cipriani, Sarah/ITV-7039-2023; PETRAGLIA,
   Felice/D-4373-2019; Maggi, Mario/AAB-8284-2019; Fambrini,
   Massimiliano/K-5835-2016
OI MAGGI, Mario/0000-0003-3267-4221; Menafra, Davide/0000-0002-4403-6801;
   Fambrini, Massimiliano/0000-0003-0461-6390
FU PRIN ("Progetti di Rilevante Interesse Nazionale") [2017S9KTNE]
FX This research was supported by a PRIN ("Progetti di Rilevante Interesse
   Nazionale": 2017S9KTNE).
CR Adibi A, 2015, J RES MED SCI, V20, P879, DOI 10.4103/1735-1995.170622
   Alvisi S, 2014, J SEX MED, V11, P2020, DOI 10.1111/jsm.12585
   Balercia G, 2007, PSYCHOTHER PSYCHOSOM, V76, P134, DOI 10.1159/000099840
   Battaglia C, 1996, ULTRASOUND OBST GYN, V7, P342, DOI 10.1046/j.1469-0705.1996.07050342.x
   Battaglia C, 2011, J SEX MED, V8, P2334, DOI 10.1111/j.1743-6109.2011.02310.x
   Battaglia C, 2011, J SEX MED, V8, P1717, DOI 10.1111/j.1743-6109.2011.02257.x
   Battaglia C, 2009, J SEX MED, V6, P2707, DOI 10.1111/j.1743-6109.2009.01402.x
   Battaglia C, 2008, J SEX MED, V5, P2853, DOI 10.1111/j.1743-6109.2008.00972.x
   Bond DS, 2011, SURG OBES RELAT DIS, V7, P1, DOI 10.1016/j.soard.2010.05.015
   Bradford A, 2006, BEHAV RES THER, V44, P1067, DOI 10.1016/j.brat.2005.08.006
   Brosens I, 2011, AM J OBSTET GYNECOL, V204, P193, DOI 10.1016/j.ajog.2010.08.009
   CAMPBELL S, 1983, LANCET, V1, P675
   Castellini G, 2019, MOL CELL ENDOCRINOL, V497, DOI 10.1016/j.mce.2019.04.009
   Chew PY, 2021, J SEX MED, V18, P99, DOI 10.1016/j.jsxm.2020.10.001
   Chien LW, 2004, ULTRASOUND OBST GYN, V23, P496, DOI 10.1002/uog.975
   Corona G, 2013, ANDROLOGY-US, V1, P864, DOI 10.1111/j.2047-2927.2013.00139.x
   Corona G, 2008, J ENDOCRINOL INVEST, V31, P1058, DOI 10.1007/BF03345652
   Corona G, 2016, J SEX MED, V13, P1347, DOI 10.1016/j.jsxm.2016.07.004
   Corona G, 2014, ASIAN J ANDROL, V16, P581, DOI 10.4103/1008-682X.126386
   CROWN S, 1966, BRIT J PSYCHIAT, V112, P917, DOI 10.1192/bjp.112.490.917
   Cuzzolaro M, 2006, Eat Weight Disord, V11, P1
   Dalle Grave R, 2007, OBESITY, V15, P2320, DOI 10.1038/oby.2007.275
   DeRogatis L, 2008, J SEX MED, V5, P357, DOI 10.1111/j.1743-6109.2007.00672.x
   FITZGERALD DE, 1977, BRIT MED J, V2, P1450, DOI 10.1136/bmj.2.6100.1450
   Gerstenberger EP, 2010, J SEX MED, V7, P3096, DOI 10.1111/j.1743-6109.2010.01871.x
   GILL RW, 1981, AM J OBSTET GYNECOL, V139, P720, DOI 10.1016/0002-9378(81)90495-6
   GOSLING RG, 1974, P ROY SOC MED, V67, P447, DOI 10.1177/00359157740676P113
   GOSWAMY RK, 1988, HUM REPROD, V3, P721, DOI 10.1093/oxfordjournals.humrep.a136772
   HOEHNSARIC R, 1988, PSYCHIAT CLIN N AM, V11, P375
   Hollis B, 2003, ULTRASOUND OBST GYN, V22, P373, DOI 10.1002/uog.231
   Kidwell CS, 2001, J NEUROIMAGING, V11, P229, DOI 10.1111/j.1552-6569.2001.tb00039.x
   Koo HS, 2018, J ULTRAS MED, V37, P851, DOI 10.1002/jum.14418
   Lotti F, 2019, J SEX MED, V16, P821, DOI 10.1016/j.jsxm.2019.03.006
   Lumb P., 2014, Critical Care Ultrasound
   Martelli V, 2012, J SEX MED, V9, P434, DOI 10.1111/j.1743-6109.2011.02517.x
   Maseroli E, 2016, ANDROLOGY-US, V4, P911, DOI 10.1111/andr.12224
   Maseroli E, 2018, SEX MED REV, V6, P508, DOI 10.1016/j.sxmr.2018.02.009
   Maseroli E, 2016, J SEX MED, V13, P1651, DOI 10.1016/j.jsxm.2016.09.009
   Mazloomdoost Donna, 2015, Sex Med Rev, V3, P245, DOI 10.1002/smrj.61
   Meston CM, 2020, J SEX MED, V17, P17, DOI 10.1016/j.jsxm.2019.10.007
   Miner M, 2012, J SEX MED, V9, P641, DOI 10.1111/j.1743-6109.2012.02649.x
   Morelli A, 2019, AM J PHYSIOL-ENDOC M, V316, pE519, DOI 10.1152/ajpendo.00377.2018
   Otunctemur A, 2015, J SEX MARITAL THER, V41, P440, DOI 10.1080/0092623X.2014.918068
   Park K, 1997, INT J IMPOT RES, V9, P27, DOI 10.1038/sj.ijir.3900258
   Petersen LJ, 1997, NEPHROL DIAL TRANSPL, V12, P1376, DOI 10.1093/ndt/12.7.1376
   Pietryga M, 2005, CIRCULATION, V112, P2496, DOI 10.1161/CIRCULATIONAHA.104.492843
   Ponholzer A, 2008, INT J IMPOT RES, V20, P100, DOI 10.1038/sj.ijir.3901605
   Rastrelli G, 2019, EXPERT REV ENDOCRINO, V14, P321, DOI 10.1080/17446651.2019.1657827
   Rastrelli G, 2014, J SEX MED, V11, P173, DOI 10.1111/jsm.12342
   Rastrelli G, 2011, J SEX MED, V8, P3433, DOI 10.1111/j.1743-6109.2011.02474.x
   Rosen R, 2000, J SEX MARITAL THER, V26, P191, DOI 10.1080/009262300278597
   Roslan NS, 2019, CURR DRUG TARGETS, V20, P146, DOI 10.2174/1389450118666170622090337
   Rowen TS, 2020, J SEX MED, V17, P585, DOI 10.1016/j.jsxm.2019.12.013
   Scaruffi E, 2019, J PSYCHOSOM OBST GYN, V40, P294, DOI 10.1080/0167482X.2018.1530210
   Spielberger C.D., 1966, Theory and Research on Anxiety
   Tarcan T, 1999, J UROLOGY, V161, P940, DOI 10.1016/S0022-5347(01)61825-1
   Trompeter SE, 2016, AM J MED, V129, P1270, DOI 10.1016/j.amjmed.2016.03.039
   Vignozzi L, 2014, MOL CELL ENDOCRINOL, V384, P143, DOI 10.1016/j.mce.2014.01.014
   Woertman L, 2012, J SEX RES, V49, P184, DOI 10.1080/00224499.2012.658586
NR 59
TC 10
Z9 10
U1 0
U2 0
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 22
PY 2021
VL 11
IS 1
AR 18899
DI 10.1038/s41598-021-98336-7
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA UW6XJ
UT WOS:000700297100027
PM 34552164
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kunin-Batson, AS
   Crain, AL
   Sherwood, NE
   Kelly, AS
   Kharbanda, EO
   Gunnar, MR
   Haapala, J
   Seburg, EM
   French, SA
AF Kunin-Batson, Alicia S.
   Crain, A. Lauren
   Sherwood, Nancy E.
   Kelly, Aaron S.
   Kharbanda, Elyse O.
   Gunnar, Megan R.
   Haapala, Jacob
   Seburg, Elisabeth M.
   French, Simone A.
TI Do Children's Health Behaviors Buffer the Impact of Cumulative
   Environmental Stress on Emerging Cardiometabolic Risk?
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE childhood; health behaviors; obesity; stress
ID VIGOROUS PHYSICAL-ACTIVITY; C-REACTIVE PROTEIN; LONGITUDINAL
   ASSOCIATIONS; OBESITY; NEIGHBORHOOD; OPPORTUNITY; INTERVENTION;
   FAMILIES; RATIO
AB Background: Previous studies have found that exposure to childhood environmental stress is associated with cardiometabolic risk. However, it is not known whether individual health behaviors disrupt this relationship. This study prospectively evaluated the relationship between cumulative environmental stress in a low-income sample and cardiometabolic risk in middle childhood and examined whether child health behaviors attenuated this relationship. Methods and Results: In a cohort of children (n=338; 57% Hispanic children; 25% Black children), environmental stressors (family and neighborhood factors representing disadvantage/deprivation) and child health behaviors (accelerometry measured physical activity; parent-reported screen time and diet recalls) were measured over 5 time points beginning when children were aged 2 to 4 years and ending when they were aged 7 to 11 years. Children's cardiometabolic risk factors (body mass index, blood pressure, triglyceride/high-density lipoprotein ratio, glucose, hemoglobin A(1c), C-reactive protein) were measured at 7 to 11 years. Emerging cardiometabolic risk was defined as having >= 1 elevations that exceeded clinical thresholds. In adjusted path analyses, greater cumulative environmental stress was associated with higher likelihood of emerging cardiometabolic risk in middle childhood (P<0.001). Higher levels of moderate to vigorous physical activity and fewer sedentary minutes attenuated the positive relationship between stress and cardiometabolic risk (P<0.05). Children with >2 hours of average daily screen time had a higher likelihood of elevated cardiometabolic risk (P<0.01), but screen time did not moderate the stress-cardiometabolic risk relationship. Dietary intake was not related to cardiometabolic risk. Conclusions: Interventions that promote moderate to vigorous physical activity and limit sedentary behavior may have particular importance for the cardiometabolic health of children exposed to high levels of cumulative environmental stress.
C1 [Kunin-Batson, Alicia S.; Kelly, Aaron S.] Univ Minnesota, Med Sch, Dept Pediat, 717 Delaware St SE, Minneapolis, MN 55414 USA.
   [Kunin-Batson, Alicia S.; Kelly, Aaron S.] Univ Minnesota, Ctr Pediat Obes Med, Med Sch, 717 Delaware St SE, Minneapolis, MN 55414 USA.
   [Crain, A. Lauren; Kharbanda, Elyse O.; Haapala, Jacob; Seburg, Elisabeth M.] HealthPartners Inst, Bloomington, MN USA.
   [Sherwood, Nancy E.; French, Simone A.] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN 55414 USA.
   [Gunnar, Megan R.] Univ Minnesota, Inst Child Dev, Minneapolis, MN 55436 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities;
   HealthPartners Institute for Education & Research; University of
   Minnesota System; University of Minnesota Twin Cities; University of
   Minnesota System; University of Minnesota Twin Cities
RP Kunin-Batson, AS (corresponding author), Univ Minnesota, Med Sch, Dept Pediat, 717 Delaware St SE, Minneapolis, MN 55414 USA.; Kunin-Batson, AS (corresponding author), Univ Minnesota, Ctr Pediat Obes Med, Med Sch, 717 Delaware St SE, Minneapolis, MN 55414 USA.
EM kunin003@umn.edu
RI Kunin-Batson, Alicia/GQY-8621-2022
OI French, Simone/0000-0003-3413-5985; Sherwood, Nancy/0000-0002-3365-9018;
   Kharbanda, Elyse/0000-0003-1806-6502; Crain, A
   Lauren/0000-0002-5050-945X; Kunin-Batson, Alicia/0000-0002-7607-5602
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development of the National Institutes of Health [R01HD090059,
   U01HD068990]; Center for Neurobehavioral Development, University of
   Minnesota
FX This work was supported by the Eunice Kennedy Shriver National Institute
   of Child Health and Human Development of the National Institutes of
   Health under award numbers R01HD090059 and U01HD068990, and in part by
   the Center for Neurobehavioral Development, University of Minnesota.
CR Acevedo-Garcia D, 2020, HEALTH AFFAIR, V39, P1693, DOI 10.1377/hlthaff.2020.00735
   Acevedo-Garcia D, 2016, HOUS POLICY DEBATE, V26, P607, DOI 10.1080/10511482.2016.1198410
   [Anonymous], 2000, GUIDE MEASURING HOUS
   Batten SV, 2004, J CLIN PSYCHIAT, V65, P249
   Bennett CM, 2007, DIABETIC MED, V24, P333, DOI 10.1111/j.1464-5491.2007.02106.x
   Carson V, 2014, INT J OBESITY, V38, P16, DOI 10.1038/ijo.2013.135
   Chetty R, 2016, AM ECON REV, V106, P855, DOI 10.1257/aer.20150572
   Choi L, 2011, MED SCI SPORT EXER, V43, P357, DOI 10.1249/MSS.0b013e3181ed61a3
   da Luz PL, 2008, CLINICS, V63, P427, DOI 10.1590/S1807-59322008000400003
   Danese A, 2014, MOL PSYCHIATR, V19, P544, DOI 10.1038/mp.2013.54
   Eagle TF, 2010, AM HEART J, V160, P1185, DOI 10.1016/j.ahj.2010.09.019
   Evans GW, 2013, PSYCHOL BULL, V139, P1342, DOI 10.1037/a0031808
   Fang KH, 2019, CHILD CARE HLTH DEV, V45, P744, DOI 10.1111/cch.12701
   Flynn JT, 2017, PEDIATRICS, V140, DOI [10.1542/peds.2017-3035, 10.1542/peds.2017-1904]
   Foster E, 2018, NUTR RES, V51, P1, DOI 10.1016/j.nutres.2017.11.001
   Foster S, 2008, PREV MED, V47, P241, DOI 10.1016/j.ypmed.2008.03.017
   French SA, 2023, PEDIATR OBES, V18, DOI 10.1111/ijpo.13055
   French Simone A, 2018, Am J Public Health, V108, P1695, DOI 10.2105/AJPH.2018.304696
   Godoy LC, 2021, JAMA CARDIOL, V6, P228, DOI 10.1001/jamacardio.2020.6050
   Soares AG, 2021, J AM HEART ASSOC, V10, DOI 10.1161/JAHA.121.021701
   Guran O, 2007, ACTA PAEDIATR, V96, P1214, DOI 10.1111/j.1651-2227.2007.00377.x
   HOLMES TH, 1967, J PSYCHOSOM RES, V11, P213, DOI 10.1016/0022-3999(67)90010-4
   Janz KF, 2002, INT J SPORTS MED, V23, pS15
   Jones M, 2021, AM J LIFESTYLE MED, V15, P158, DOI 10.1177/1559827619867693
   King AC, 2019, MED SCI SPORT EXER, V51, P1203, DOI 10.1249/MSS.0000000000001946
   Kuczmarski Robert J, 2000, CDC growth charts: United States
   Lande MB, 2008, PEDIATRICS, V122, P1252, DOI 10.1542/peds.2007-3162
   Langford Rebecca, 2015, Int J Behav Nutr Phys Act, V12, P15, DOI 10.1186/s12966-015-0167-7
   Lee H, 2014, AM J PUBLIC HEALTH, V104, pE70, DOI 10.2105/AJPH.2013.301806
   Li YW, 2017, ATHEROSCLEROSIS, V259, P75, DOI 10.1016/j.atherosclerosis.2017.02.003
   Lobelo F, 2020, PEDIATRICS, V145, DOI 10.1542/peds.2019-3992
   Ludwig J, 2013, AM ECON REV, V103, P226, DOI 10.1257/aer.103.3.226
   Magge SN, 2017, PEDIATRICS, V140, DOI 10.1542/peds.2017-1603
   Miller AL, 2018, OBESITY, V26, P1117, DOI 10.1002/oby.22155
   Miller PE, 2011, PUBLIC HEALTH NUTR, V14, P306, DOI 10.1017/S1368980010001655
   Nader PR, 2008, JAMA-J AM MED ASSOC, V300, P295, DOI 10.1001/jama.300.3.295
   Naylor PJ, 2009, BRIT J SPORT MED, V43, P10, DOI 10.1136/bjsm.2008.053447
   Phillips CM, 2019, CLIN NUTR, V38, P1620, DOI 10.1016/j.clnu.2018.08.028
   Qureshi F, 2019, PEDIATRICS, V143, DOI 10.1542/peds.2018-2004
   Ridker PM, 2003, CIRCULATION, V108, pE81, DOI 10.1161/01.CIR.0000093381.57779.67
   SCHAKEL SF, 1988, J AM DIET ASSOC, V88, P1268
   Schakel SF, 2001, J FOOD COMPOS ANAL, V14, P315, DOI 10.1006/jfca.2001.0992
   Schmitz KH, 2004, J SCHOOL HEALTH, V74, P370, DOI 10.1111/j.1746-1561.2004.tb06632.x
   Schuz B, 2020, Handbook of behavior change, P385, DOI [10.1017/9781108677318.027, DOI 10.1017/9781108677318.027]
   Sherwood NE, 2013, CONTEMP CLIN TRIALS, V36, P544, DOI 10.1016/j.cct.2013.09.015
   Siervo M, 2015, BRIT J NUTR, V113, P1, DOI 10.1017/S0007114514003341
   Skrede T, 2019, OBES REV, V20, P55, DOI 10.1111/obr.12758
   Smith KE, 2020, J NEURODEV DISORD, V12, DOI 10.1186/s11689-020-09337-y
   Sperber JF, 2023, JAMA NETW OPEN, V6, DOI 10.1001/jamanetworkopen.2023.35237
   Story M, 2009, MILBANK Q, V87, P71, DOI 10.1111/j.1468-0009.2009.00548.x
   Suglia SF, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-1149
   Timperio A, 2004, PREV MED, V38, P39, DOI 10.1016/j.ypmed.2003.09.026
   Troller-Renfree SV, 2022, P NATL ACAD SCI USA, V119, DOI 10.1073/pnas.2115649119
   Twenge Jean M, 2018, Prev Med Rep, V12, P271, DOI 10.1016/j.pmedr.2018.10.003
   Urbina EM, 2013, PEDIATRICS, V131, pE1082, DOI 10.1542/peds.2012-1726
   Valderhaug TG, 2020, OBESITY, V28, P1571, DOI 10.1002/oby.22911
   Valérie J, 2022, PEDIATR OBES, V17, DOI 10.1111/ijpo.12897
   VANHORN LV, 1993, J AM DIET ASSOC, V93, P1396, DOI 10.1016/0002-8223(93)92241-O
   Whitman A., 2022, Assistant Secretary for Planning and Evaluation, V1, P1
   Zhang W, 2012, SOC SCI MED, V75, P1006, DOI 10.1016/j.socscimed.2012.05.012
NR 60
TC 0
Z9 0
U1 1
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD SEP 17
PY 2024
VL 13
IS 18
AR e032492
DI 10.1161/JAHA.123.032492
PG 12
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA G1Y7Z
UT WOS:001314672800009
PM 39248253
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mücke, M
   Ludyga, S
   Colledge, F
   Gerber, M
AF Mucke, Manuel
   Ludyga, Sebastian
   Colledge, Flora
   Gerber, Markus
TI Influence of Regular Physical Activity and Fitness on Stress Reactivity
   as Measured with the Trier Social Stress Test Protocol: A Systematic
   Review
SO SPORTS MEDICINE
LA English
DT Review
ID PSYCHOSOCIAL STRESS; CARDIOVASCULAR REACTIVITY; PSYCHOLOGICAL STRESS;
   PHYSIOLOGICAL-RESPONSE; CORTISOL RESPONSES; METABOLIC SYNDROME;
   LABORATORY STRESS; EXERCISE; HEALTH; RECOVERY
AB Background Psychosocial stress is associated with multiple health complaints. Research to date suggests that regular physical activity (PA) and higher cardiorespiratory fitness may reduce stress reactivity and therefore contribute to a reduction of stress-related risk factors. While previous reviews have not differentiated between stressors, we focus on psychosocial stress elicited with the Trier Social Stress Test (TSST).
   Objective Our objective was to examine the effect of regular PA and cardiorespiratory fitness on stress reactivity, with a particular focus on the TSST. The TSST is the laboratory task most widely used to induce socio-evaluative stress and elicits stronger stress reactions than most other cognitive stressor tasks.
   Methods A systematic search within various databases was performed in January 2018. The following outcomes were considered: cortisol, heart rate, psychological stress reactivity, and potential moderators (age, sex, exercise intensity, assessment mode, and psychological constructs).
   Results In total, 14 eligible studies were identified. Cortisol and heart rate reactivity were attenuated by higher PA or better fitness in seven of twelve studies and four of nine studies, respectively. Two of four studies reported smaller increases in anxiety and smaller decreases in calmness in physically active/fitter participants. Three of four studies found that higher PA/fitness was associated with more favorable mood in response to the TSST.
   Conclusion About half of the studies suggested that higher PA/fitness levels were associated with an attenuated response to psychosocial stress. Currently, most evidence is based on cross-sectional analyses. Therefore, a great need for further studies with longitudinal or experimental designs exists.
C1 [Mucke, Manuel; Gerber, Markus] Univ Basel, Div Sport & Psychosocial Hlth, Dept Sport Exercise & Hlth, Birsstr 320 B, CH-4052 Basel, Switzerland.
   [Ludyga, Sebastian; Colledge, Flora] Univ Basel, Div Sport & Hlth Pedag, Dept Sport Exercise & Hlth, Birsstr 320 B, CH-4052 Basel, Switzerland.
C3 Swiss School of Public Health (SSPH+); University of Basel; Swiss School
   of Public Health (SSPH+); University of Basel
RP Mücke, M (corresponding author), Univ Basel, Div Sport & Psychosocial Hlth, Dept Sport Exercise & Hlth, Birsstr 320 B, CH-4052 Basel, Switzerland.
EM manuel.muecke@unibas.ch
RI Gerber, Markus/H-8654-2014; Hanke, Manuel/AFZ-0876-2022; Ludyga,
   Sebastian/H-9316-2019
OI Ludyga, Sebastian/0000-0002-3905-7894; Gerber,
   Markus/0000-0001-6140-8948
CR Allen AP, 2017, NEUROBIOL STRESS, V6, P113, DOI 10.1016/j.ynstr.2016.11.001
   [Anonymous], PHYS ACTIVITY STRESS
   [Anonymous], STRESSREGULATION SPO
   [Anonymous], 2007, ENCY STRESS, DOI DOI 10.1016/B978-012373947-6.00014-3
   [Anonymous], STRESSREGULATION SPO
   [Anonymous], PSYCHOBIOLOGY PHYS A
   [Anonymous], 2006, PSYCHOBIOLOGY PHYS A
   [Anonymous], 2015, BMJ-BRIT MED J, DOI [DOI 10.1136/BMJ.G7647, 10.4271/2015-01-1534]
   Armbruster D, 2011, HORM BEHAV, V60, P105, DOI 10.1016/j.yhbeh.2011.03.010
   Bauman A E, 2004, J Sci Med Sport, V7, P6, DOI 10.1016/S1440-2440(04)80273-1
   Bergmann N, 2014, ENDOCR CONNECT, V3, pR55, DOI 10.1530/EC-14-0031
   Bibbey A, 2013, INT J PSYCHOPHYSIOL, V90, P28, DOI 10.1016/j.ijpsycho.2012.10.018
   Biddle SJH, 2011, BRIT J SPORT MED, V45, P886, DOI 10.1136/bjsports-2011-090185
   Booth J, 2015, BMC NEUROL, V15, DOI 10.1186/s12883-015-0456-4
   Borenstein M, 2009, Introduction to meta-analysis, P421
   Brosschot JF, 2005, PSYCHONEUROENDOCRINO, V30, P1043, DOI 10.1016/j.psyneuen.2005.04.008
   BuskeKirschbaum A, 1997, PSYCHOSOM MED, V59, P419, DOI 10.1097/00006842-199707000-00012
   Campbell J, 2012, PSYCHONEUROENDOCRINO, V37, P1111, DOI 10.1016/j.psyneuen.2011.12.010
   Chida Y, 2010, HYPERTENSION, V55, P1026, DOI 10.1161/HYPERTENSIONAHA.109.146621
   Childs E, 2014, FRONT PHYSIOL, V5, DOI 10.3389/fphys.2014.00161
   Cohen S, 2007, JAMA-J AM MED ASSOC, V298, P1685, DOI 10.1001/jama.298.14.1685
   Connor-Smith JK, 2007, J PERS SOC PSYCHOL, V93, P1080, DOI 10.1037/0022-3514.93.6.1080
   Dickerson SS, 2004, PSYCHOL BULL, V130, P355, DOI 10.1037/0033-2909.130.3.355
   Dockray S, 2009, J ADOLESCENT HEALTH, V45, P344, DOI 10.1016/j.jadohealth.2009.06.014
   Foley P, 2010, NEUROSCI BIOBEHAV R, V35, P91, DOI 10.1016/j.neubiorev.2010.01.010
   Forcier K, 2006, HEALTH PSYCHOL, V25, P723, DOI 10.1037/0278-6133.25.6.723
   Fuchs R, 2015, Z GESUNDHEITSPSYCHOL, V23, P60, DOI 10.1026/0943-8149/a000137
   Gerber M, 2008, DEUT Z SPORTMED, V59, P168
   Gerber M, 2017, PSYCHONEUROENDOCRINO, V80, P104, DOI 10.1016/j.psyneuen.2017.03.004
   Gerber M, 2016, NEUROPSYCH DIS TREAT, V12, P1977, DOI 10.2147/NDT.S110656
   Gerber M, 2009, SCAND J PUBLIC HEALT, V37, P801, DOI 10.1177/1403494809350522
   Glynn LM, 2002, PSYCHOSOM MED, V64, P714, DOI 10.1097/01.PSY.0000031574.42041.23
   Hackney Anthony C, 2006, Expert Rev Endocrinol Metab, V1, P783, DOI 10.1586/17446651.1.6.783
   Harrison LK, 2001, PSYCHOPHYSIOLOGY, V38, P601, DOI 10.1111/1469-8986.3840601
   Hellhammer DH, 2009, PSYCHONEUROENDOCRINO, V34, P163, DOI 10.1016/j.psyneuen.2008.10.026
   Hollanders JJ, 2017, BIOL SEX DIFFER, V8, DOI 10.1186/s13293-017-0144-8
   Holmes ME, 2010, OBES REV, V11, P492, DOI 10.1111/j.1467-789X.2009.00680.x
   Hoogendoorn WE, 2000, SPINE, V25, P2114, DOI 10.1097/00007632-200008150-00017
   Houston JM, 1997, PERCEPT MOTOR SKILL, V84, P1447, DOI 10.2466/pms.1997.84.3c.1447
   Jackson EM, 2006, PSYCHOPHYSIOLOGY, V43, P57, DOI 10.1111/j.1469-8986.2006.00373.x
   Jayasinghe SU, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0169746
   Jayasinghe SU, 2016, ENDOCRINE, V51, P369, DOI 10.1007/s12020-015-0687-6
   Kajantie E, 2006, PSYCHONEUROENDOCRINO, V31, P151, DOI 10.1016/j.psyneuen.2005.07.002
   Keinan G, 2005, PERS INDIV DIFFER, V39, P625, DOI 10.1016/j.paid.2005.02.009
   Kirschbaum C, 1999, PSYCHOSOM MED, V61, P154, DOI 10.1097/00006842-199903000-00006
   KIRSCHBAUM C, 1993, NEUROPSYCHOBIOLOGY, V28, P76, DOI 10.1159/000119004
   Kivimäki M, 2006, SCAND J WORK ENV HEA, V32, P431, DOI 10.5271/sjweh.1049
   Kjaer M, 1992, Exerc Sport Sci Rev, V20, P161
   Klaperski S, 2014, J BEHAV MED, V37, P1118, DOI 10.1007/s10865-014-9562-9
   Klaperski S, 2013, PSYCHOL SPORT EXERC, V14, P266, DOI 10.1016/j.psychsport.2012.11.003
   Klaperski S, 2012, Z SPORTPSYCHOL, V19, P80, DOI 10.1026/1612-5010/a000061
   Kudielka B., 2007, Social neuroscience: Integrating biological and psychological explanations of social behavior, P56
   Kudielka BM, 2005, BIOL PSYCHOL, V69, P113, DOI 10.1016/j.biopsycho.2004.11.009
   Kudielka BM, 2009, PSYCHONEUROENDOCRINO, V34, P2, DOI 10.1016/j.psyneuen.2008.10.004
   Levine A, 2007, PHYSIOL BEHAV, V90, P43, DOI 10.1016/j.physbeh.2006.08.025
   Linden W, 1997, J PSYCHOSOM RES, V42, P117, DOI 10.1016/S0022-3999(96)00240-1
   Lovallo WR, 2011, BIOL PSYCHOL, V86, P121, DOI 10.1016/j.biopsycho.2010.01.006
   LUGER A, 1987, NEW ENGL J MED, V316, P1309, DOI 10.1056/NEJM198705213162105
   Lustyk MKB, 2010, BIOL PSYCHOL, V83, P84, DOI 10.1016/j.biopsycho.2009.11.003
   Martikainen S, 2013, J CLIN ENDOCR METAB, V98, pE619, DOI 10.1210/jc.2012-3745
   McEwen BS, 2008, EUR J PHARMACOL, V583, P174, DOI 10.1016/j.ejphar.2007.11.071
   Middlebrooks J.S., 2008, The effects of childhood stress on health across the lifespan
   Moher D, 2015, SYST REV-LONDON, V4, DOI 10.1186/s13643-015-0087-2
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Netz Y, 2005, PSYCHOL AGING, V20, P272, DOI 10.1037/0882-7974.20.2.272
   Phillips AC, 2013, INT J PSYCHOPHYSIOL, V90, P1, DOI 10.1016/j.ijpsycho.2013.02.002
   Pruessner JC, 2003, PSYCHONEUROENDOCRINO, V28, P916, DOI 10.1016/S0306-4530(02)00108-7
   Puterman E, 2011, PSYCHOSOM MED, V73, P604, DOI 10.1097/PSY.0b013e318229e1e0
   Redmond N, 2013, J AM HEART ASSOC, V2, DOI 10.1161/JAHA.113.000447
   Rimmele U, 2007, PSYCHONEUROENDOCRINO, V32, P627, DOI 10.1016/j.psyneuen.2007.04.005
   Rimmele U, 2009, PSYCHONEUROENDOCRINO, V34, P190, DOI 10.1016/j.psyneuen.2008.08.023
   Rohleder N, 2007, PERS SOC PSYCHOL B, V33, P69, DOI 10.1177/0146167206293986
   Roozendaal B, 2009, NAT REV NEUROSCI, V10, P423, DOI 10.1038/nrn2651
   Roy MP, 2004, HORM BEHAV, V46, P618, DOI 10.1016/j.yhbeh.2004.06.015
   Segerstrom SC, 2004, PSYCHOL BULL, V130, P601, DOI 10.1037/0033-2909.130.4.601
   Sjörs A, 2009, BMC MUSCULOSKEL DIS, V10, DOI 10.1186/1471-2474-10-63
   Sommer M, 2011, PHARMACOPSYCHIATRY, V44, P129, DOI 10.1055/s-0031-1277166
   Strahler J, 2016, PSYCHONEUROENDOCRINO, V68, P14, DOI 10.1016/j.psyneuen.2016.02.022
   Thayer JF, 2000, J AFFECT DISORDERS, V61, P201, DOI 10.1016/S0165-0327(00)00338-4
   Thoits PA, 2010, J HEALTH SOC BEHAV, V51, pS41, DOI 10.1177/0022146510383499
   von Dawans B, 2011, PSYCHONEUROENDOCRINO, V36, P514, DOI 10.1016/j.psyneuen.2010.08.004
   Warburton DER, 2006, CAN MED ASSOC J, V174, P801, DOI 10.1503/cmaj.051351
   Wolfram M, 2013, STRESS HEALTH, V29, P143, DOI 10.1002/smi.2439
   Wood CJ, 2018, ANXIETY STRESS COPIN, V31, P135, DOI 10.1080/10615806.2017.1390083
   Wyss T, 2016, SPORTS MED-OPEN, V2, DOI 10.1186/s40798-016-0057-9
   Zanstra YJ, 2011, BIOL PSYCHOL, V86, P98, DOI 10.1016/j.biopsycho.2010.05.002
NR 86
TC 121
Z9 126
U1 1
U2 48
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 0112-1642
EI 1179-2035
J9 SPORTS MED
JI Sports Med.
PD NOV
PY 2018
VL 48
IS 11
BP 2607
EP 2622
DI 10.1007/s40279-018-0979-0
PG 16
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Sport Sciences
GA GW9AW
UT WOS:000447274700009
PM 30159718
DA 2025-06-11
ER

PT J
AU Funakubo, N
   Eguchi, E
   Hayashi, R
   Hirosaki, M
   Shirai, K
   Okazaki, K
   Nakano, H
   Hayashi, F
   Omata, J
   Imano, H
   Iso, H
   Ohira, T
AF Funakubo, Narumi
   Eguchi, Eri
   Hayashi, Rie
   Hirosaki, Mayumi
   Shirai, Kokoro
   Okazaki, Kanako
   Nakano, Hironori
   Hayashi, Fumikazu
   Omata, Junichi
   Imano, Hironori
   Iso, Hiroyasu
   Ohira, Tetsuya
TI Effects of a laughter program on body weight and mental health among
   Japanese people with metabolic syndrome risk factors: a randomized
   controlled trial
SO BMC GERIATRICS
LA English
DT Article
DE Body mass index; Happiness; Health-related quality of life; Laughter
   yoga; Revised life orientation test; Stress
ID QUALITY-OF-LIFE; CARDIOVASCULAR-DISEASE; EXERCISE PROGRAM; STRESS;
   NEUROENDOCRINE; OPTIMISM; VERSION; IMPACT; YOGA
AB Background: While there have been several intervention studies on the psychological effects of laughter, few have examined both the psychological and physical effects. This study investigates the effects of a laughter program on body weight, body mass index (BMI), subjective stress, depression, and health-related quality of life (HRQOL) among Japanese community-dwelling individuals using a randomized controlled trial with a waitlist.
   Methods: Overall, 235 participants (37 men and 198 women) aged 43-79 years (mean 66.9, median 67.0) were randomized into laughter intervention and control groups (n = 117 and n = 118, respectively) to participate in a 12-week laughter program. Body weight, subjective stress, subjective well-being, and HRQOL were measured at the baseline, with a 12-week follow-up. The laughter program intervention's effects on these factors were analyzed using an analysis of covariance adjusted by age, sex, risk factors, medication, and area. Furthermore, Pearson's correlation and a general linear model analyzed the relationship between participants' BMI and psychological index changes.
   Results: The comprehensive laughter program significantly improved the mean body weight (p = 0.008), BMI (p= 0.006), subjective stress (p= 0.004), subjective well-being (p = 0.002), optimism (p = 0.03), and physical component summary (PCS) scores of HRQOL (p= 0.04). A similar tendency occurred for the mean changes in BMI and subjective stress score by area, sex, and age. Moreover, there was a significant and negative correlation between the change in BMI and PCS change (p = 0.04).
   Conclusion: The comprehensive 12-week laughter intervention program, mainly comprising laughter yoga, significantly improved physical and psychological functions such as body weight, BMI, subjective stress, subjective well-being, and HRQOL among predominantly elderly Japanese community-dwelling individuals with metabolic syndrome risk factors. Moreover, PCS improved among participants who reduced BMI after the intervention. These results suggest that the laughter program may help reduce body weight in participants with metabolic syndrome risk factors by reducing stress and improving HRQOL and mental health factors, such as subjective well-being and optimism.
C1 [Funakubo, Narumi; Eguchi, Eri; Hirosaki, Mayumi; Okazaki, Kanako; Nakano, Hironori; Hayashi, Fumikazu; Ohira, Tetsuya] Fukushima Med Univ, Dept Epidemiol, Sch Med, 1 Hikarigaoka, Fukushima 9601295, Japan.
   [Hayashi, Rie; Shirai, Kokoro; Imano, Hironori; Iso, Hiroyasu] Osaka Univ, Dept Social Med, Grad Sch Med, Publ Hlth, Osaka, Japan.
   [Hirosaki, Mayumi] Kyoto Univ, Ctr Southeast Asian Studies, Kyoto, Japan.
   [Okazaki, Kanako; Omata, Junichi] Fukushima Med Univ, Dept Phys Therapy, Sch Hlth Sci, Fukushima, Japan.
   [Okazaki, Kanako; Nakano, Hironori; Hayashi, Fumikazu; Ohira, Tetsuya] Fukushima Med Univ, Radiat Med Sci Ctr Fukushima Hlth Management Surv, Fukushima, Japan.
   [Omata, Junichi] Fukushima Med Univ, Dept Anat, Sch Med, Fukushima, Japan.
   [Imano, Hironori] Kindai Univ, Dept Publ Hlth, Fac Med, Osaka, Japan.
C3 Fukushima Medical University; The University of Osaka; Kyoto University;
   Fukushima Medical University; Fukushima Medical University; Fukushima
   Medical University; Kindai University (Kinki University)
RP Ohira, T (corresponding author), Fukushima Med Univ, Dept Epidemiol, Sch Med, 1 Hikarigaoka, Fukushima 9601295, Japan.; Ohira, T (corresponding author), Fukushima Med Univ, Radiat Med Sci Ctr Fukushima Hlth Management Surv, Fukushima, Japan.
EM teoohira@fmu.ac.jp
RI OMATA, JUNICHI/JZF-9999-2024; HIROSAKI, Mayumi/HCH-1388-2022
OI hayashi, fumikazu/0000-0002-6888-6640; Eguchi, Eri/0000-0002-1598-1847
FU Japan Agency for Medical Research and Development [JP16lk0310019h0001,
   JP17lk0310035h0001]; Foundation for Total Health Promotion [408]; Japan
   Society for the Promotion of Science (JSPS) KAKENHI [18 K19688,
   19H03901, 20 K21719]
FX This research was supported by the Japan Agency for Medical Research and
   Development under Grant Agreement Nos [JP16lk0310019h0001 and
   JP17lk0310035h0001] and Foundation for Total Health Promotion (408) and
   Japan Society for the Promotion of Science (JSPS) KAKENHI under Grant
   Agreement Nos [18 K19688, 19H03901, and 20 K21719].
CR Ainsworth BE, 2011, MED SCI SPORT EXER, V43, P1575, DOI 10.1249/MSS.0b013e31821ece12
   BERK LS, 1989, AM J MED SCI, V298, P390, DOI 10.1097/00000441-198912000-00006
   Brown LM, 2005, INT J GERIATR PSYCH, V20, P911, DOI 10.1002/gps.1375
   Buchowski MS, 2007, INT J OBESITY, V31, P131, DOI 10.1038/sj.ijo.0803353
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   COUSINS N, 1976, NEW ENGL J MED, V295, P1458, DOI 10.1056/NEJM197612232952605
   Dogan MD, 2020, HOLIST NURS PRACT, V34, P35, DOI 10.1097/HNP.0000000000000363
   Farifteh S, 2014, IRAN J CANCER PREV, V7, P179
   Fukuhara S., 2004, MANUAL SF 8 JAPANESE
   Hayashi K, 2016, J EPIDEMIOL, V26, P546, DOI 10.2188/jea.JE20150196
   Hayashi T, 2007, BIOMED RES-TOKYO, V28, P281, DOI 10.2220/biomedres.28.281
   Hirosaki M, 2018, QUAL LIFE RES, V27, P639, DOI 10.1007/s11136-017-1750-y
   Hirosaki M, 2013, GERIATR GERONTOL INT, V13, P152, DOI 10.1111/j.1447-0594.2012.00877.x
   HUBERT HB, 1983, CIRCULATION, V67, P968, DOI 10.1161/01.CIR.67.5.968
   Ikeda S, 2021, J EPIDEMIOL, V31, P125, DOI 10.2188/jea.JE20190140
   Imai Y, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2017-019104
   Itami J., 1994, Jpn J Psychosom Med, V34, P565
   Lavan N, 2017, NEUROPSYCHOLOGIA, V95, P30, DOI 10.1016/j.neuropsychologia.2016.12.012
   Lefante JJ, 2005, QUAL LIFE RES, V14, P665, DOI 10.1007/s11136-004-0784-0
   Lin CY, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051371
   Matsuzawa Y, 2005, J ATHEROSCLER THROMB, V12, P301, DOI 10.5551/jat.12.301
   Ohira T, 2006, CANCER-AM CANCER SOC, V106, P2076, DOI 10.1002/cncr.21829
   Sakurada K, 2020, J EPIDEMIOL, V30, P188, DOI 10.2188/jea.JE20180249
   SCHEIER MF, 1994, J PERS SOC PSYCHOL, V67, P1063, DOI 10.1037/0022-3514.67.6.1063
   SCHEIER MF, 1992, COGNITIVE THER RES, V16, P201, DOI 10.1007/BF01173489
   Segerstrom S., 2006, BREAKING MURPHYS LAW
   Shahidi M, 2011, INT J GERIATR PSYCH, V26, P322, DOI 10.1002/gps.2545
   Sheikh JI., 1986, Geriatric Depression Scale (GDS): Recent evidence and development of a shorter version, DOI DOI 10.1300/J018V05N01_09
   Shinji S., 2002, Jpn J Health Psychol, V15, P59, DOI [DOI 10.11560/JAHP.15.1_59, 10.11560/jahp.15.1_59, DOI 10.11560/JAHP.15.159]
   Shirai K, 2009, CIRCULATION, V120, P956, DOI 10.1161/CIRCULATIONAHA.108.834176
   Stanton AL, 2002, PSYCHO-ONCOLOGY, V11, P93, DOI 10.1002/pon.574
   Sugishita K, 2017, CLIN GERONTOLOGIST, V40, P233, DOI 10.1080/07317115.2016.1199452
   Suzuki T, 2004, J BONE MINER METAB, V22, P602, DOI 10.1007/s00774-004-0530-2
   Tamada Y, 2021, J EPIDEMIOL, V31, P301, DOI 10.2188/jea.JE20200051
   Tanaka M., 2011, STRUCT FUNCT, V10, P8
   Tavakoli Tahmine, 2019, Middle East J Dig Dis, V11, P211, DOI 10.15171/mejdd.2019.151
   van der Wal CN, 2019, SOC SCI MED, V232, P473, DOI 10.1016/j.socscimed.2019.02.018
   Watanabe K, 2018, OBES REV, V19, P1557, DOI 10.1111/obr.12725
   Yaribeygi H, 2017, EXCLI J, V16, P1057, DOI 10.17179/excli2017-480
   Yoshino S, 1996, J RHEUMATOL, V23, P793
   Yoshino S., 1996, Japanese Journal of Psychosomatic Medicine, V36, P559
   Zhao JP, 2019, J ADV NURS, V75, P2435, DOI 10.1111/jan.14000
NR 42
TC 5
Z9 5
U1 0
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2318
J9 BMC GERIATR
JI BMC Geriatr.
PD APR 23
PY 2022
VL 22
IS 1
AR 361
DI 10.1186/s12877-022-03038-y
PG 12
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 0S0IX
UT WOS:000785967600004
PM 35461239
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Doom, JR
   Reid, BM
   Blanco, E
   Burrows, R
   Lozoff, B
   Gahagan, S
AF Doom, Jenalee R.
   Reid, Brie M.
   Blanco, Estela
   Burrows, Raquel
   Lozoff, Betsy
   Gahagan, Sheila
TI Infant Psychosocial Environment Predicts Adolescent Cardiometabolic
   Risk: A Prospective Study
SO JOURNAL OF PEDIATRICS
LA English
DT Article
ID ADVERSE CHILDHOOD EXPERIENCES; BODY-MASS INDEX; CARDIOVASCULAR RISK;
   METABOLIC SYNDROME; HEALTH; DISEASE; OBESITY; STRESS; LIFE; PREVALENCE
AB Objective To prospectively assess whether the infant psychosocial environment was associated with cardiometabolic risk as early as adolescence.
   Study design Participants were recruited in Santiago, Chile, and have been followed from infancy. Inclusion criteria included healthy infants with birth weight >= 3 kg and a stable caregiver. The psychosocial environment, including depressive symptoms, stressful life events, poor support for child development, father absence, and socioeconomic status, was reported by mothers at 6-12 months. Body mass index (BMI) z score was assessed at 5 and 10 years. BMI z score, waist-to-hip ratio, systolic and diastolic blood pressure, fat mass and body fat percentage, fasting glucose, total and high-density lipoprotein cholesterol, and homeostatic model of insulin resistance were tested in adolescence.
   Results Adolescents ranged from 16 to 18 years of age (n = 588; 48.1 % female). A poorer infant psychosocial environment was associated with BMI z score at 10 years (beta = 0.10, 95% CI = 0.00-0.19) and in adolescence (beta = 0.15, 95% CI = 0.06-0.24) but not at 5 years. A poorer infant psychosocial environment was associated with higher blood pressure (beta = 0.15, 95% CI = 0.05-0.24), greater anthropometric risk (beta = 0.13, 95% CI = 0.03-0.22), greater biomarker (triglycerides, homeostatic model assessment of insulin resistance, total cholesterol) risk (beta = 0.12, 95% CI = 0.02-0.22), and a higher likelihood of metabolic syndrome in adolescence (aOR = 1.50; 95% CI = 1.062.12).
   Conclusions These findings demonstrate that a poorer infant psychosocial environment was associated with greater adolescent cardiometabolic risk. The results support screening for infants' psychosocial environments and further research into causality, mechanisms, prevention, and intervention.
C1 [Doom, Jenalee R.; Lozoff, Betsy; Gahagan, Sheila] Univ Michigan, Ctr Human Growth & Dev, 300 N Ingalls St,10th Floor, Ann Arbor, MI 48109 USA.
   [Doom, Jenalee R.; Lozoff, Betsy] Univ Michigan, Dept Pediat, Ann Arbor, MI 48109 USA.
   [Reid, Brie M.] Univ Minnesota, Inst Child Dev, 51 E River Rd, Minneapolis, MN 55455 USA.
   [Blanco, Estela; Gahagan, Sheila] Univ Calif San Diego, Dept Pediat, San Diego, CA 92103 USA.
   [Blanco, Estela] Univ Chile, Sch Publ Hlth, Doctoral Program Publ Hlth, Santiago, Chile.
   [Burrows, Raquel] Univ Chile, Inst Nutr & Tecnol Alimentos, Santiago, Chile.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; University of Minnesota System;
   University of Minnesota Twin Cities; University of California System;
   University of California San Diego; Universidad de Chile; Universidad de
   Chile
RP Doom, JR (corresponding author), Univ Michigan, Ctr Human Growth & Dev, 300 N Ingalls St,10th Floor, Ann Arbor, MI 48109 USA.
EM jrdoom@umich.edu
RI Burrows, Raquel/A-8489-2015; Blanco, Estela/AAI-9276-2021; Reid,
   Brie/ABC-9782-2020; Blanco, Estela/A-2541-2014
OI Doom, Jenalee/0000-0003-2857-0817; Blanco, Estela/0000-0002-6232-9210;
   Burrows, Raquel/0000-0001-9155-0689
FU National Institutes of Health [F32HD088029, R01HD14122, R01HD33487,
   R01HL088530]
FX Funded by the National Institutes of Health (F32HD088029 [to J.D.],
   R01HD14122 [to B.L.], R01HD33487 [to B.L. and S.G.], and R01HL088530 [to
   S.G.]). The funder had no role in the study design; the collection,
   analysis, and interpretation of data; the writing of the report; or the
   decision to submit the manuscript for publication. The authors declare
   no conflicts of interest.
CR Albala C, 2002, PUBLIC HEALTH NUTR, V5, P123, DOI 10.1079/PHN2001283
   ALVAREZ MD, 1985, REV MED CHILE, V113, P243
   [Anonymous], 2003, Home observation for measurement of the environment: Administration manual
   Bradley RH, 1996, EARLY DEV PARENTING, V5, P251, DOI 10.1002/(SICI)1099-0917(199612)5:4<251::AID-EDP137>3.0.CO;2-I
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Danese A, 2014, MOL PSYCHIATR, V19, P544, DOI 10.1038/mp.2013.54
   Danese A, 2009, ARCH PEDIAT ADOL MED, V163, P1135, DOI 10.1001/archpediatrics.2009.214
   Evans GW, 2013, CHILD DEV PERSPECT, V7, P43, DOI 10.1111/cdep.12013
   Felitti VJ, 1998, AM J PREV MED, V14, P245, DOI 10.1016/S0749-3797(98)00017-8
   Gilbert LK, 2015, AM J PREV MED, V48, P345, DOI 10.1016/j.amepre.2014.09.006
   Gluckman PD, 2009, EARLY LIFE ORIGINS OF HUMAN HEALTH AND DISEASE, P1, DOI 10.1159/000221148
   Goodman E, 2005, CIRCULATION, V111, P1970, DOI 10.1161/01.CIR.0000161957.34198.2B
   Hakulinen C, 2016, PSYCHOSOM MED, V78, P171, DOI 10.1097/PSY.0000000000000246
   Hao G, 2018, INT J CARDIOL, V255, P168, DOI 10.1016/j.ijcard.2017.12.063
   HOLMES TH, 1967, J PSYCHOSOM RES, V11, P213, DOI 10.1016/0022-3999(67)90010-4
   Kain J, 2002, EUR J CLIN NUTR, V56, P200, DOI 10.1038/sj.ejcn.1601301
   Khuc K, 2012, INT J PEDIAT, V2012, DOI 10.1155/2012/478610
   Klassen SA, 2016, CHILD ABUSE NEGLECT, V56, P1, DOI 10.1016/j.chiabu.2016.04.002
   Lozoff B, 2003, PEDIATRICS, V112, P846
   McConnell R, 2015, ENVIRON HEALTH PERSP, V123, P360, DOI 10.1289/ehp.1307031
   McEwen BS, 1998, ANN NY ACAD SCI, V840, P33, DOI 10.1111/j.1749-6632.1998.tb09546.x
   Nusslock R, 2016, BIOL PSYCHIAT, V80, P23, DOI 10.1016/j.biopsych.2015.05.017
   Pacheco LS, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.170132
   Power C, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0119985
   Pretty C, 2013, BMC PEDIATR, V13, DOI 10.1186/1471-2431-13-208
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   RADLOFF LS, 1991, J YOUTH ADOLESCENCE, V20, P149, DOI 10.1007/BF01537606
   Raposa EB, 2014, HEALTH PSYCHOL, V33, P410, DOI 10.1037/a0032752
   Shin SH, 2012, CHILD ABUSE NEGLECT, V36, P84, DOI 10.1016/j.chiabu.2011.08.007
   Shonkoff JP, 2012, PEDIATRICS, V129, pE232, DOI 10.1542/peds.2011-2663
   Slopen N, 2012, BRAIN BEHAV IMMUN, V26, P239, DOI 10.1016/j.bbi.2011.11.003
   Suglia SF, 2018, CIRCULATION, V137, pE15, DOI 10.1161/CIR.0000000000000536
   Thomas C, 2008, PEDIATRICS, V121, pE1240, DOI 10.1542/peds.2007-2403
   Torres SJ, 2007, NUTRITION, V23, P887, DOI 10.1016/j.nut.2007.08.008
   Tsai CH, 2011, ENDOCRINE, V40, P256, DOI 10.1007/s12020-011-9466-1
   Wells NM, 2010, AM J PUBLIC HEALTH, V100, P2507, DOI 10.2105/AJPH.2009.184291
   Zimmet P, 2007, PEDIATR DIABETES, V8, P299, DOI 10.1111/j.1399-5448.2007.00271.x
NR 37
TC 12
Z9 12
U1 1
U2 7
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
EI 1097-6833
J9 J PEDIATR-US
JI J. Pediatr.
PD JUN
PY 2019
VL 209
BP 85
EP +
DI 10.1016/j.jpeds.2019.01.058
PG 8
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA HZ1OA
UT WOS:000468615300017
PM 30876752
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Albaladejo-Blázquez, N
   Ferrer-Cascales, R
   Ruiz-Robledillo, N
   Sánchez-Sansegundo, M
   Clement-Carbonell, V
   Zaragoza-Martí, A
AF Albaladejo-Blazquez, Natalia
   Ferrer-Cascales, Rosario
   Ruiz-Robledillo, Nicolas
   Sanchez-Sansegundo, Miriam
   Clement-Carbonell, Violeta
   Zaragoza-Marti, Ana
TI Poor Dietary Habits in Bullied Adolescents: The Moderating Effects of
   Diet on Depression
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE bullying; diet; depression; adolescents
ID MEDITERRANEAN DIET; BULLYING VICTIMIZATION; METABOLIC SYNDROME;
   PERCEIVED STRESS; ALLOSTATIC LOAD; MENTAL-HEALTH; ASSOCIATION; QUALITY;
   CHILDREN; LIFE
AB The prevalence of bullying has increased dramatically during recent years, with numerous negative consequences for the health and quality of life of bullied adolescents. Although negative psychological consequences of this type of situation have been widely investigated, no previous research has evaluated the effects of bullying victimization on dietary habits, and its relationship with psychological outcomes, such as depression. For this reason, the main aim of the present study was to evaluate the association between bullying, dietary habits, and depression in a sample of 527 Spanish adolescents. The results obtained showed that being bullied was correlated negatively with healthy dietary habits and positively with depression. Moderation analysis revealed dietary habits as moderator of the association between bullying and depression. These results underline the relevance of diet in the phenomenon of bullying, especially in victims, as could be related to the high levels of depression characteristic of this population. The inclusion of nutritional education in intervention programs oriented to victims of bullying might significantly improve their efficacy, reducing depression levels.
C1 [Albaladejo-Blazquez, Natalia; Ferrer-Cascales, Rosario; Ruiz-Robledillo, Nicolas; Sanchez-Sansegundo, Miriam; Clement-Carbonell, Violeta] Univ Alicante, Fac Hlth Sci, Dept Hlth Psychol, Alicante 03690, Spain.
   [Zaragoza-Marti, Ana] Univ Alicante, Fac Hlth Sci, Dept Nursing, Alicante 03690, Spain.
C3 Universitat d'Alacant; Universitat d'Alacant
RP Ferrer-Cascales, R (corresponding author), Univ Alicante, Fac Hlth Sci, Dept Hlth Psychol, Alicante 03690, Spain.
EM natalia.albaladejo@ua.es; rosario.ferrer@ua.es; nicolas.ruiz@ua.es;
   miriam.sanchez@ua.es; violeta.clement@ua.es; ana.zaragoza@ua.es
RI Clement, Violeta/U-3474-2017; Sanchez-SanSegundo, Miriam/U-3451-2017;
   Marí, Ana/U-3449-2017; Ferrer-Cascales, R./U-3448-2017; Ruiz-Robledillo,
   Nicolas/U-3452-2017; Albaladejo-Blazquez, Natalia/U-3453-2017
OI Ferrer-Cascales, R./0000-0001-6015-7454; Ruiz-Robledillo,
   Nicolas/0000-0002-7522-5162; Sanchez-SanSegundo,
   Miriam/0000-0003-2114-6503; Albaladejo-Blazquez,
   Natalia/0000-0002-9116-9092
CR Arseneault L, 2018, J CHILD PSYCHOL PSYC, V59, P405, DOI 10.1111/jcpp.12841
   Baiden P, 2017, PSYCHIAT RES, V255, P238, DOI 10.1016/j.psychres.2017.05.018
   Caballo VE, 2012, BEHAV PSYCHOL, V20, P625
   Cantone Elisa, 2015, Clin Pract Epidemiol Ment Health, V11, P58, DOI 10.2174/1745017901511010058
   Carleton RN, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0058067
   Cartwright M, 2003, HEALTH PSYCHOL, V22, P362, DOI 10.1037/0278-6133.22.4.362
   da Silva JL, 2017, CIENC SAUDE COLETIVA, V22, P2329, DOI 10.1590/1413-81232017227.16242015
   Dai J, 2008, AM J CLIN NUTR, V88, P1364, DOI 10.3945/ajcn.2008.26528
   Dao TK, 2006, J ADOLESCENT HEALTH, V39, P277, DOI 10.1016/j.jadohealth.2005.11.001
   De Vriendt T, 2012, BRIT J NUTR, V108, P371, DOI 10.1017/S0007114511005708
   Fantaguzzi C, 2018, EUR J HEALTH ECON, V19, P641, DOI 10.1007/s10198-017-0908-4
   Ford R, 2017, AUST NZ J PSYCHIAT, V51, P897, DOI 10.1177/0004867417700275
   Frisén A, 2010, ACTA PAEDIATR, V99, P597, DOI 10.1111/j.1651-2227.2009.01664.x
   García-Toro M, 2016, J AFFECT DISORDERS, V194, P105, DOI 10.1016/j.jad.2015.12.064
   Hayes A. F., 2017, INTRO MEDIATION MODE
   Herrero J, 2006, COMPUT HUM BEHAV, V22, P830, DOI 10.1016/j.chb.2004.03.007
   Holt EM, 2009, J AM DIET ASSOC, V109, P414, DOI 10.1016/j.jada.2008.11.036
   Holt MK, 2015, PEDIATRICS, V135, pE496, DOI 10.1542/peds.2014-1864
   Hou FL, 2013, APPETITE, V68, P63, DOI 10.1016/j.appet.2013.04.010
   Juster RP, 2010, NEUROSCI BIOBEHAV R, V35, P2, DOI 10.1016/j.neubiorev.2009.10.002
   Kaltiala-Heino R, 2011, ADOLESC HEALTH MED T, V2, P37, DOI 10.2147/AHMT.S11554
   Khalid S, 2016, BRIT J NUTR, V116, P2097, DOI 10.1017/S0007114516004359
   Kodish T, 2016, CRISIS, V37, P241, DOI 10.1027/0227-5910/a000378
   Kusano Y, 2016, ANN HUM BIOL, V43, P34, DOI 10.3109/03014460.2015.1013985
   Mattei J, 2013, J NUTR, V143, P1753, DOI 10.3945/jn.113.180141
   McEwen BS, 2005, J PSYCHIATR NEUROSCI, V30, P315
   McEwen BS, 1998, ANN NY ACAD SCI, V840, P33, DOI 10.1111/j.1749-6632.1998.tb09546.x
   Michels N, 2012, APPETITE, V59, P762, DOI 10.1016/j.appet.2012.08.010
   Michels N, 2017, INT J EAT DISORDER, V50, P471, DOI 10.1002/eat.22593
   Modecki KL, 2014, J ADOLESCENT HEALTH, V55, P602, DOI 10.1016/j.jadohealth.2014.06.007
   Molendijk M, 2018, J AFFECT DISORDERS, V226, P346, DOI 10.1016/j.jad.2017.09.022
   O'Neil A, 2014, AM J PUBLIC HEALTH, V104, pE31, DOI 10.2105/AJPH.2014.302110
   Zarate-Garza PP, 2017, HARVARD REV PSYCHIAT, V25, P89, DOI 10.1097/HRP.0000000000000137
   Psaltopoulou T, 2013, ANN NEUROL, V74, P580, DOI 10.1002/ana.23944
   Sampasa-Kanyinga H, 2015, APPETITE, V89, P41, DOI 10.1016/j.appet.2015.01.020
   Sampasa-Kanyinga H, 2014, APPETITE, V79, P76, DOI 10.1016/j.appet.2014.04.007
   Schröder H, 2010, INT J PEDIATR OBES, V5, P516, DOI 10.3109/17477161003777417
   Serra-Majem L, 2004, PUBLIC HEALTH NUTR, V7, P931, DOI 10.1079/PHN2004556
   Serra-Majem L, 2001, PUBLIC HEALTH NUTR, V4, P1433, DOI 10.1079/PHN2001234
   Stefan L, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040419
   Yin XQ, 2017, PSYCHIAT RES, V256, P59, DOI 10.1016/j.psychres.2017.06.037
   Zych I., 2017, Protecting children against bullying and its consequences, P5, DOI [DOI 10.1007/978-3-319-53028-4_2, 10.1007/978-3-319-53028-42]
NR 42
TC 11
Z9 11
U1 2
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD AUG
PY 2018
VL 15
IS 8
AR 1569
DI 10.3390/ijerph15081569
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA GS0GQ
UT WOS:000443168200009
PM 30042364
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Reynolds, MA
AF Reynolds, Mark A.
TI Modifiable risk factors in periodontitis: at the intersection of aging
   and disease
SO PERIODONTOLOGY 2000
LA English
DT Review
ID BODY-MASS INDEX; POLYUNSATURATED FATTY-ACIDS; ALCOHOL-CONSUMPTION;
   METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; COMORBIDITY MEASURES;
   INSULIN-RESISTANCE; SEXUAL-DIMORPHISM; HEART-DISEASE;
   PORPHYROMONAS-GINGIVALIS
AB Chronic inflammation is a prominent feature of aging and of common age-related diseases, including atherosclerosis, cancer and periodontitis. This volume examines modifiable risk factors for periodontitis and other chronic inflammatory diseases. Oral bacterial communities and viral infections, particularly with cytomegalovirus and other herpesviruses, elicit distinct immune responses and are central in the initiation of periodontal diseases. Risk of disease is dynamic and changes in response to complex interactions of genetic, environmental and stochastic factors over the lifespan. Many modifiable risk factors, such as smoking and excess caloric intake, contribute to increases in systemic markers of inflammation and can modify gene regulation through a variety of biologic mechanisms (e.g. epigenetic modifications). Periodontitis and other common chronic inflammatory diseases share multiple modifiable risk factors, such as tobacco smoking, psychological stress and depression, alcohol consumption, obesity, diabetes, metabolic syndrome and osteoporosis. Interventions that target modifiable risk factors have the potential to improve risk profiles for periodontitis as well as for other common chronic diseases.
RI Reynolds, Mark/AAO-9707-2021
CR Adams TD, 2007, NEW ENGL J MED, V357, P753, DOI 10.1056/NEJMoa066603
   Afman L, 2006, J AM DIET ASSOC, V106, P569, DOI 10.1016/j.jada.2006.01.001
   Alani A, 2014, PERIODONTOL 2000, V64, P198, DOI 10.1111/j.1600-0757.2012.00454.x
   Aljada A, 2002, J CLIN ENDOCR METAB, V87, P1419, DOI 10.1210/jc.87.3.1419
   Anand P, 2008, PHARM RES-DORDR, V25, P2097, DOI 10.1007/s11095-008-9661-9
   [Anonymous], 2006, IMMUN AGEING, DOI DOI 10.1186/1742-4933-3-5
   [Anonymous], 2011, National Diabetes Fact Sheet: National Estimates and General Information on Diabetes and Prediabetes in the United States, 2011
   [Anonymous], COCHRANE DATABASE SY
   Avina-Zubieta JA, 2008, ARTHRIT RHEUM-ARTHR, V59, P1690, DOI 10.1002/art.24092
   Avrani S, 2011, NATURE, V474, P604, DOI 10.1038/nature10172
   Barros SP, 2000, PERIODONTOL 2000, V64, P95
   Bartold PM, 2013, PERIODONTOL 2000, V62, P203, DOI 10.1111/j.1600-0757.2012.00450.x
   Bartolomucci A, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004265
   Beaglehole R, 2010, LANCET, V376, P1619, DOI 10.1016/S0140-6736(10)61929-0
   Berchtold NC, 2008, P NATL ACAD SCI USA, V105, P15605, DOI 10.1073/pnas.0806883105
   Bergstrom Jan, 2006, J Evid Based Dent Pract, V6, P33, DOI 10.1016/j.jebdp.2005.12.018
   Berry JD, 2012, NEW ENGL J MED, V366, P321, DOI 10.1056/NEJMoa1012848
   Bosch JA, 2007, PSYCHOSOM MED, V69, P597, DOI 10.1097/PSY.0B013E318148C682
   Bouchard P, 2006, J PERIODONTOL, V77, P479, DOI 10.1902/jop.2006.050128
   Brochner AC, 2009, SCAND J TRAUMA RESUS, V17, DOI 10.1186/1757-7241-17-43
   Bullon P, 2014, PERIODONTOL 2000, V64, P139, DOI 10.1111/j.1600-0757.2012.00455.x
   Calder PC, 2009, BRIT J NUTR, V101, pS1, DOI 10.1017/S0007114509377867
   Calle EE, 1999, NEW ENGL J MED, V341, P1097, DOI 10.1056/NEJM199910073411501
   Calle EE, 2003, NEW ENGL J MED, V348, P1625, DOI 10.1056/NEJMoa021423
   Callewaert F, 2010, J ENDOCRINOL, V207, P127, DOI 10.1677/JOE-10-0209
   Callewaert F, 2010, J BONE MINER RES, V25, P617, DOI 10.1359/jbmr.090828
   Cekici A, 2014, PERIODONTOL 2000, V64, P57, DOI 10.1111/prd.12002
   Chapple ILC, 2007, PERIODONTOL 2000, V43, P160, DOI 10.1111/j.1600-0757.2006.00178.x
   Chapple ILC, 2009, J AM DENT ASSOC, V140, P178, DOI 10.14219/jada.archive.2009.0131
   Chapple ILC, 1996, J CLIN PATHOL-CL MOL, V49, pM247
   Chen GY, 2010, NAT REV IMMUNOL, V10, P826, DOI 10.1038/nri2873
   Chu YT, 2010, BMC HEALTH SERV RES, V10, DOI 10.1186/1472-6963-10-140
   Chung HY, 2011, J DENT RES, V90, P830, DOI 10.1177/0022034510387794
   Chung HY, 2009, AGEING RES REV, V8, P18, DOI 10.1016/j.arr.2008.07.002
   Closa D, 2004, IUBMB LIFE, V56, P185, DOI 10.1080/15216540410001701642
   Compston JE, 2001, PHYSIOL REV, V81, P419, DOI 10.1152/physrev.2001.81.1.419
   Conrad D, 2013, AM J RESP CELL MOL, V48, P150, DOI 10.1165/rcmb.2012-0059PS
   Contreras A, 2014, PERIODONTOL 2000, V64, P40, DOI 10.1111/j.1600-0757.2012.00448.x
   Cugini C, 2013, J ORAL MICROBIOL, V5, DOI 10.3402/jom.v5i0.19804
   D'Aiuto F, 2008, J CLIN ENDOCR METAB, V93, P3989, DOI 10.1210/jc.2007-2522
   Dandona P, 2001, J CLIN ENDOCR METAB, V86, P3257, DOI 10.1210/jc.86.7.3257
   Dandona P, 2007, CURR OPIN CLIN NUTR, V10, P511, DOI 10.1097/MCO.0b013e3281e38774
   Davey ME, 2000, MICROBIOL MOL BIOL R, V64, P847, DOI 10.1128/MMBR.64.4.847-867.2000
   de Magalhaes JP, 2010, AGEING RES REV, V9, P315, DOI 10.1016/j.arr.2009.10.006
   de Roos B, 2009, BRIT J PHARMACOL, V158, P413, DOI 10.1111/j.1476-5381.2009.00189.x
   Dolinoy DC, 2006, ENVIRON HEALTH PERSP, V114, P567, DOI 10.1289/ehp.8700
   Ebersole JL, 2013, PERIODONTOL 2000, V62, P163, DOI 10.1111/prd.12005
   Eke PI, 2012, J DENT RES, V91, P914, DOI 10.1177/0022034512457373
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Fialkow L, 2007, FREE RADICAL BIO MED, V42, P153, DOI 10.1016/j.freeradbiomed.2006.09.030
   Amaral CDF, 2008, J PERIODONTOL, V79, P993, DOI 10.1902/jop.2008.070525 
   Gabet Yankel, 2011, Curr Osteoporos Rep, V9, P177, DOI 10.1007/s11914-011-0072-1
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Gandhi M., 2012, Int J Genetic Engineering, V2, P19
   GAULDIE J, 1987, P NATL ACAD SCI USA, V84, P7251, DOI 10.1073/pnas.84.20.7251
   Genco RJ, 2013, PERIODONTOL 2000, V62, P59, DOI 10.1111/j.1600-0757.2012.00457.x
   Gentschew L, 2012, MOL NUTR FOOD RES, V56, P524, DOI 10.1002/mnfr.201100630
   Gijsen R, 2001, J CLIN EPIDEMIOL, V54, P661, DOI 10.1016/S0895-4356(00)00363-2
   Goetzel RZ, 2012, HEALTH AFFAIR, V31, P2474, DOI 10.1377/hlthaff.2011.0819
   Hajishengallis G, 2012, NAT REV MICROBIOL, V10, P717, DOI 10.1038/nrmicro2873
   Halliwell B, 2006, J NEUROCHEM, V97, P1634, DOI 10.1111/j.1471-4159.2006.03907.x
   Han JY, 2012, J PERIODONTAL IMPLAN, V42, P3, DOI 10.5051/jpis.2012.42.1.3
   HARMAN D, 1956, J GERONTOL, V11, P298, DOI 10.1093/geronj/11.3.298
   Herath TDK, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0058496
   Hibbing ME, 2010, NAT REV MICROBIOL, V8, P15, DOI 10.1038/nrmicro2259
   Hoffman C, 1996, JAMA-J AM MED ASSOC, V276, P1473, DOI 10.1001/jama.276.18.1473
   Hold GL, 2008, BIOCHEM J, V410, P225, DOI 10.1042/BJ20071341
   Hussain SP, 2007, INT J CANCER, V121, P2373, DOI 10.1002/ijc.23173
   Ijzerman RG, 2003, CLIN SCI, V104, P247, DOI 10.1042/CS20020318
   Jansson L, 2008, J CLIN PERIODONTOL, V35, P379, DOI 10.1111/j.1600-051X.2008.01210.x
   Jeffcoat M, 2012, J DENT RES, V91, P753
   Jirtle RL, 2007, NAT REV GENET, V8, P253, DOI 10.1038/nrg2045
   Johannsen A, 2014, PERIODONTOL 2000, V64, P111, DOI 10.1111/j.1600-0757.2012.00456.x
   Karasik D, 2008, ANN HUM GENET, V72, P696, DOI 10.1111/j.1469-1809.2008.00447.x
   Katon WJ, 2005, DIABETES CARE, V28, P2668, DOI 10.2337/diacare.28.11.2668
   KIECOLTGLASER JK, 1995, LANCET, V346, P1194, DOI 10.1016/S0140-6736(95)92899-5
   Kinane DF, 2003, CRIT REV ORAL BIOL M, V14, P430, DOI 10.1177/154411130301400605
   Klein BEK, 2002, DIABETES CARE, V25, P1790, DOI 10.2337/diacare.25.10.1790
   Kongstad J, 2008, J CLIN PERIODONTOL, V35, P1032, DOI 10.1111/j.1600-051X.2008.01325.x
   Kumada H, 2008, ORAL MICROBIOL IMMUN, V23, P60, DOI 10.1111/j.1399-302X.2007.00392.x
   Kung Hsiang-Ching, 2008, Natl Vital Stat Rep, V56, P1
   Lages EJP, 2012, J CLIN PERIODONTOL, V39, P115, DOI 10.1111/j.1600-051X.2011.01809.x
   Lakschevitz F, 2011, CURR DIABETES REV, V7, P433, DOI 10.2174/157339911797579205
   Lefevre M, 2005, AM J CLIN NUTR, V82, P957, DOI 10.1093/ajcn/82.5.957
   Levy BD, 2001, NAT IMMUNOL, V2, P612, DOI 10.1038/89759
   Linden GJ, 2013, J CLIN PERIODONTOL, V40, pS8, DOI [10.1902/jop.2013.1340010, 10.1111/jcpe.12064]
   Lloyd-Jones DM, 2006, CIRCULATION, V113, P791, DOI 10.1161/CIRCULATIONAHA.105.548206
   Lloyd-Jones D, 2010, CIRCULATION, V121, pE46, DOI 10.1161/CIRCULATIONAHA.109.192667
   Lloyd-Jones DM, 2007, AM J CARDIOL, V99, P535, DOI 10.1016/j.amjcard.2006.09.099
   Lloyd-Lones DM, 2003, ARCH INTERN MED, V163, P1966, DOI 10.1001/archinte.163.16.1966
   Lönnroth K, 2008, BMC PUBLIC HEALTH, V8, DOI 10.1186/1471-2458-8-289
   Maeda H, 1998, BIOCHEMISTRY-MOSCOW+, V63, P854
   Manabe I, 2011, CIRC J, V75, P2739, DOI 10.1253/circj.CJ-11-1184
   Mariotto AB, 2011, JNCI-J NATL CANCER I, V103, P117, DOI 10.1093/jnci/djq495
   Marriott I, 2006, IMMUNOL RES, V34, P177, DOI 10.1385/IR:34:3:177
   Mathers CD, 2006, PLOS MED, V3, DOI 10.1371/journal.pmed.0030442
   Mavrides N, 2013, DEPRESS ANXIETY, V30, P328, DOI 10.1002/da.22051
   McKee SA, 2007, ARCH INTERN MED, V167, P716, DOI 10.1001/archinte.167.7.716
   McTiernan A, 2008, NAT REV CANCER, V8, P205, DOI 10.1038/nrc2325
   Miles EA, 2012, BRIT J NUTR, V107, pS171, DOI 10.1017/S0007114512001560
   Minino AM, 2011, NCHS DATA BRIEF, V115, P1
   Mitchell BD, 2008, AM HEART J, V155, P823, DOI 10.1016/j.ahj.2008.01.019
   Moussavi S, 2007, LANCET, V370, P851, DOI 10.1016/S0140-6736(07)61415-9
   Nesbitt MJ, 2010, AGING CLIN EXP RES, V22, P238, DOI 10.1007/BF03324802
   O'Rourke RW, 2009, WORLD J SURG, V33, P2007, DOI 10.1007/s00268-009-0067-6
   Ober C, 2008, NAT REV GENET, V9, P911, DOI 10.1038/nrg2415
   Ogden CL, 2012, JAMA-J AM MED ASSOC, V307, P483, DOI [10.1001/jama.2012.39, 10.1001/jama.2012.40]
   Palmer RM, 2005, J CLIN PERIODONTOL, V32, P180, DOI 10.1111/j.1600-051X.2005.00786.x
   Palmer RJ, 2014, PERIODONTOL 2000, V64, P20, DOI 10.1111/j.1600-0757.2012.00453.x
   Park M, 2013, GEN HOSP PSYCHIAT, V35, P217, DOI 10.1016/j.genhosppsych.2013.01.006
   Paster BJ, 2001, J BACTERIOL, V183, P3770, DOI 10.1128/JB.183.12.3770-3783.2001
   Paster BJ, 2006, PERIODONTOL 2000, V42, P80, DOI 10.1111/j.1600-0757.2006.00174.x
   Pitiphat W, 2003, J DENT RES, V82, P509, DOI 10.1177/154405910308200704
   Preshaw PM, 2012, DIABETOLOGIA, V55, P21, DOI 10.1007/s00125-011-2342-y
   Rehm J, 2003, ADDICTION, V98, P1209, DOI 10.1046/j.1360-0443.2003.00467.x
   Rehm J, 2010, ADDICTION, V105, P817, DOI 10.1111/j.1360-0443.2010.02899.x
   Rehm J, 2009, LANCET, V373, P2223, DOI 10.1016/S0140-6736(09)60746-7
   Reynolds MA, 2009, NUTRITION, V25, P88, DOI 10.1016/j.nut.2008.07.003
   Rezzi S, 2009, EXP GERONTOL, V44, P356, DOI 10.1016/j.exger.2009.02.008
   Roger VL, 2012, CIRCULATION, V125, pE2, DOI [10.1161/CIR.0b013e31823ac046, 10.1161/CIR.0b013e3182456d46]
   Romeo GR, 2012, ARTERIOSCL THROM VAS, V32, P1771, DOI 10.1161/ATVBAHA.111.241869
   Romeo J, 2010, P NUTR SOC, V69, P341, DOI 10.1017/S0029665110001904
   Roubenoff R, 2003, AM J MED, V115, P429, DOI 10.1016/j.amjmed.2003.05.001
   Ryder MI, 2007, PERIODONTOL 2000, V43, P267, DOI 10.1111/j.1600-0757.2006.00163.x
   Samokhvalov AV, 2010, EPIDEMIOL INFECT, V138, P1789, DOI 10.1017/S0950268810000774
   Sawada N, 2007, CLIN EXP IMMUNOL, V148, P529, DOI 10.1111/j.1365-2249.2007.03346.x
   Schaefer AS, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000378
   Schäfer I, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015941
   Schetter AJ, 2010, CARCINOGENESIS, V31, P37, DOI 10.1093/carcin/bgp272
   Schneeweiss S, 2004, J GEN INTERN MED, V19, P444, DOI 10.1111/j.1525-1497.2004.30109.x
   Sears B, 2009, J AM COLL NUTR, V28, p482S, DOI 10.1080/07315724.2009.10718115
   Seda O, 2008, HYPERTENSION, V51, P1156, DOI 10.1161/HYPERTENSIONAHA.107.105247
   Shepherd Simon, 2011, Evid Based Dent, V12, P76, DOI 10.1038/sj.ebd.6400808
   Shiau HJ, 2014, PERIODONTOL 2000, V64, P81, DOI 10.1111/prd.12033
   Shiau HJ, 2010, J PERIODONTOL, V81, P1505, DOI 10.1902/jop.2010.100045
   Shiau HJ, 2010, J PERIODONTOL, V81, P1379, DOI 10.1902/jop.2010.100044
   Shimazaki Y, 2005, J PERIODONTOL, V76, P1534, DOI 10.1902/jop.2005.76.9.1534
   Shulman GI, 2000, J CLIN INVEST, V106, P171, DOI 10.1172/JCI10583
   Simopoulos AP, 2011, WORLD REV NUTR DIET, V102, P10, DOI 10.1159/000327785
   Simopoulos AP, 2011, MOL NEUROBIOL, V44, P203, DOI 10.1007/s12035-010-8162-0
   Singh T, 2011, AGEING RES REV, V10, P319, DOI 10.1016/j.arr.2010.11.002
   Singh-Dang T, 2014, PERIODONTOL 2000, V64, P154, DOI 10.1111/prd.12001
   Sjöström L, 2007, NEW ENGL J MED, V357, P741, DOI 10.1056/NEJMoa066254
   Slots J, 2007, CURR OPIN INFECT DIS, V20, P278, DOI 10.1097/QCO.0b013e3280964da0
   Slots J, 2010, PERIODONTOL 2000, V53, P89, DOI 10.1111/j.1600-0757.2009.00325.x
   Sperry JL, 2008, J TRAUMA, V64, P572, DOI 10.1097/TA.0b013e3181650fdf
   Stabholz A, 2010, PERIODONTOL 2000, V53, P138, DOI 10.1111/j.1600-0757.2010.00340.x
   Stern A, 2012, GENOME RES, V22, P1985, DOI 10.1101/gr.138297.112
   Stern A, 2011, BIOESSAYS, V33, P43, DOI 10.1002/bies.201000071
   Stukenborg GJ, 2001, MED CARE, V39, P727, DOI 10.1097/00005650-200107000-00009
   Talhout R, 2011, INT J ENV RES PUB HE, V8, P613, DOI 10.3390/ijerph8020613
   Tang J, 2008, STROKE, V39, P1938, DOI 10.1161/STROKEAHA.107.504688
   Tarannum Fouzia, 2012, Indian J Hum Genet, V18, P9, DOI 10.4103/0971-6866.96638
   Taylor G W, 2001, Ann Periodontol, V6, P99, DOI 10.1902/annals.2001.6.1.99
   Tezal M, 2005, J PERIODONTOL, V76, P406, DOI 10.1902/jop.2005.76.3.406
   Tezal M, 2004, J CLIN PERIODONTOL, V31, P484, DOI 10.1111/j.1600-051X.2004.00503.x
   Tezal M, 2001, J PERIODONTOL, V72, P183, DOI 10.1902/jop.2001.72.2.183
   Tominaga GT, 2008, J TRAUMA, V64, P578
   Tonetti M S, 1998, Ann Periodontol, V3, P88
   Ubeda F, 2008, ADV EXP MED BIOL, V626, P101
   Valderas JM, 2009, ANN FAM MED, V7, P357, DOI 10.1370/afm.983
   Van Dyke TE, 2007, PERIODONTOL 2000, V45, P158, DOI 10.1111/j.1600-0757.2007.00229.x
   van Meijgaard J, 2012, PREV CHRONIC DIS, V9, DOI 10.5888/pcd9.110295
   Vashishth D, 2000, BONE, V26, P375, DOI 10.1016/S8756-3282(00)00236-2
   Walter S, 2011, NEUROBIOL AGING, V32, DOI 10.1016/j.neurobiolaging.2011.05.026
   Ward BW, 2013, PREV CHRONIC DIS, V10, DOI 10.5888/pcd10.120203
   Warren KR, 2014, PERIODONTOL 2000, V64, P127, DOI 10.1111/prd.12036
   Weiss LA, 2006, NAT GENET, V38, P218, DOI 10.1038/ng1726
   Weylandt KH, 2011, CARCINOGENESIS, V32, P897, DOI 10.1093/carcin/bgr049
   Willett WC, 2008, ASIA PAC J CLIN NUTR, V17, P1
   Wyman L, 2012, ANN EPIDEMIOL, V22, P638, DOI 10.1016/j.annepidem.2012.06.102
   Yu BP, 1996, ANN NY ACAD SCI, V786, P1, DOI 10.1111/j.1749-6632.1996.tb39047.x
   Zamberlan N, 1996, EUR J PEDIATR, V155, P377, DOI 10.1007/s004310050421
   Zhang YH, 2008, ORG BIOMOL CHEM, V6, P3371, DOI 10.1039/b809090d
NR 174
TC 138
Z9 156
U1 0
U2 73
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0906-6713
EI 1600-0757
J9 PERIODONTOL 2000
JI Periodontol. 2000
PD FEB
PY 2014
VL 64
IS 1
BP 7
EP 19
DI 10.1111/prd.12047
PG 13
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA 268FX
UT WOS:000328156500001
PM 24320953
DA 2025-06-11
ER

PT J
AU Conti, C
   Di Francesco, G
   Severo, M
   Lanzara, R
   Richards, K
   Guagnano, MT
   Porcelli, P
AF Conti, Chiara
   Di Francesco, Giulia
   Severo, Melania
   Lanzara, Roberta
   Richards, Katie
   Guagnano, Maria Teresa
   Porcelli, Piero
TI Alexithymia and metabolic syndrome: the mediating role of binge eating
SO EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
LA English
DT Article
DE Alexithymia; Binge eating; Distress; Metabolic syndrome; Obesity;
   Structural equation modeling
ID 3RD NATIONAL-HEALTH; HOSPITAL ANXIETY; OBESE-PATIENTS; PREVALENCE;
   DEPRESSION; DISORDERS; SCALE; COMORBIDITY; PERSONALITY; POPULATION
AB Purpose Alexithymia, a personality trait characterized by difficulties in emotional processing, has been associated with unhealthy behaviors and chronic medical conditions. This study aimed to further develop our understanding of this complex relationship by investigating whether alexithymia increases the risk of metabolic syndrome (MetS) in participants with obesity or overweight through the mediating role of binge eating (BE). Methods A consecutive sample of 238 treatment-seeking patients with obesity or overweight were recruited. Alexithymia (TAS-20), binge eating symptoms (BES), body mass index (BMI), and depression and anxiety symptoms (HADS) were concurrently assessed. Results Almost half of the participants met the criteria for MetS (44.12%). Compared to patients without MetS, those with MetS were older, had a longer duration of overweight, and had a higher BMI (p < 0.01). Individual with MetS also had higher HADS, BES, and TAS-20 scores, particularly difficulty identifying and describing feelings. The structural equation modeling (SEM) analysis revealed that BES levels exerted a significant direct effect on MetS (p < 0.01), and that TAS-20 levels exerted a significant direct effect on BES (p < 0.01), anxiety (p < 0.001) and depression (p < 0.001). Moreover, psychological distress (anxiety,p = 0.01, and depression,p = .05) indirectly affected MetS through the mediating effect of BES, and TAS-20 (p = 0.01) indirectly affected MetS through the mediating effect of HADS and BES. Finally, age had a significant direct effect on MetS (p < 0.001). Conclusion Our findings indicate that alexithymia is a concurrent causative factor to the development of MetS through the mediating role of BE and psychological distress.
C1 [Conti, Chiara; Di Francesco, Giulia; Severo, Melania; Porcelli, Piero] Univ G dAnnunzio, Dept Psychol Hlth & Territorial Sci, Via Vestini 31, I-66100 Chieti, Italy.
   [Lanzara, Roberta] Sapienza Univ Rome, Dept Dynam & Clin Psychol, Rome, Italy.
   [Richards, Katie] Kings Coll London, Dept Psychol Med, London, England.
   [Guagnano, Maria Teresa] Univ G dAnnunzio, Dept Med & Aging, Chieti, Italy.
C3 G d'Annunzio University of Chieti-Pescara; Sapienza University Rome;
   University of London; King's College London; G d'Annunzio University of
   Chieti-Pescara
RP Conti, C (corresponding author), Univ G dAnnunzio, Dept Psychol Hlth & Territorial Sci, Via Vestini 31, I-66100 Chieti, Italy.
EM cconti@unich.it
RI Porcelli, Piero/AAU-3921-2021; Richards, Katie/GXV-3017-2022; SEVERO,
   Melania/HKE-8612-2023; GUAGNANO, MARIA TERESA/AAT-1701-2021
OI Richards, Katie/0000-0003-3826-6317; Severo, Melania/0000-0003-1929-497X
FU Universita degli Studi G. D'Annunzio Chieti Pescara within the CRUI-CARE
   Agreement; Health Foundation Scaling Up programme
FX Open access funding provided by Universita degli Studi G. D'Annunzio
   Chieti Pescara within the CRUI-CARE Agreement. This research did not
   receive any specific grant from funding agencies in the public,
   commercial, or not-for-profit sectors. KR is supported by the Health
   Foundation Scaling Up programme.
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Amianto F, 2015, BMC PSYCHIATRY, V15, DOI 10.1186/s12888-015-0445-6
   Amianto F, 2012, PSYCHIAT RES, V200, P502, DOI 10.1016/j.psychres.2012.07.036
   [Anonymous], 1988, STAT POWER ANAL BEHA
   Arcelus J, 2011, ARCH GEN PSYCHIAT, V68, P724, DOI 10.1001/archgenpsychiatry.2011.74
   Association AP, 2013, Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
   Bagby RM, 2020, J PSYCHOSOM RES, V131, DOI 10.1016/j.jpsychores.2020.109940
   BAGBY RM, 1994, J PSYCHOSOM RES, V38, P23, DOI 10.1016/0022-3999(94)90005-1
   Balkau B, 2002, DIABETES METAB, V28, P364
   Bardosa F, 2011, COMPR PSYCHIAT, V53, P754, DOI [10.1016/j.comppsych.2010.11.004, DOI 10.1016/J.COMPPSYCH.2010.11.004]
   Bergmann N, 2014, ENDOCR CONNECT, V3, pR55, DOI 10.1530/EC-14-0031
   Bollen KA, 2002, ANNU REV PSYCHOL, V53, P605, DOI 10.1146/annurev.psych.53.100901.135239
   Bulik CM, 2002, INT J EAT DISORDER, V32, P72, DOI 10.1002/eat.10072
   Conti C, 2019, EUR EAT DISORD REV, V27, P628, DOI 10.1002/erv.2696
   Da Ros A, 2011, EAT WEIGHT DISORD-ST, V16, pE24
   Declercq F, 2010, J CLIN PSYCHOL, V66, P1076, DOI 10.1002/jclp.20715
   Di Cesare M, 2016, LANCET, V387, P1377, DOI 10.1016/s0140-6736(16)30054-x
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Goldstein BI, 2009, J CLIN PSYCHIAT, V70, P1078, DOI 10.4088/JCP.08r04505
   GORMALLY J, 1982, ADDICT BEHAV, V7, P47, DOI 10.1016/0306-4603(82)90024-7
   Grilo CM, 2013, COMPR PSYCHIAT, V54, P209, DOI 10.1016/j.comppsych.2012.07.012
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Haase L, 2015, FRONT BEHAV NEUROSCI, V9, DOI 10.3389/fnbeh.2015.00229
   Helmers KF, 1999, J PSYCHOSOM RES, V47, P635, DOI 10.1016/S0022-3999(99)00067-7
   Honkalampi K, 2011, PSYCHOTHER PSYCHOSOM, V80, P359, DOI 10.1159/000327583
   Honkalampi K, 2010, J PSYCHOSOM RES, V68, P269, DOI 10.1016/j.jpsychores.2009.05.010
   Hruby A, 2015, PHARMACOECONOMICS, V33, P673, DOI 10.1007/s40273-014-0243-x
   Hudson JI, 2007, BIOL PSYCHIAT, V61, P348, DOI 10.1016/j.biopsych.2006.03.040
   Hudson JI, 2010, AM J CLIN NUTR, V91, P1568, DOI 10.3945/ajcn.2010.29203
   Karukivi M, 2016, PSYCHIAT RES, V236, P58, DOI 10.1016/j.psychres.2015.12.034
   Kojima M, 2012, BIOPSYCHOSOC MED, V6, DOI 10.1186/1751-0759-6-21
   Kovalic AJ, 2019, TRANSL GASTROENT HEP, V4, DOI 10.21037/tgh.2019.08.09
   Lemche E, 2013, PSYCHIAT RES-NEUROIM, V214, P66, DOI 10.1016/j.pscychresns.2013.05.006
   Li SW, 2015, PSYCHIAT RES, V227, P1, DOI 10.1016/j.psychres.2015.02.006
   Luminet O, 2018, CUP, DOI DOI 10.1017/9781108241595
   McNeill AM, 2005, DIABETES CARE, V28, P385, DOI 10.2337/diacare.28.2.385
   Morie KP, 2018, ALEXITHYMIA MALADAPT
   Nightingale BA, 2019, CURR OBES REP, V8, P112, DOI 10.1007/s13679-019-00333-5
   Norton S, 2013, J PSYCHOSOM RES, V74, P74, DOI 10.1016/j.jpsychores.2012.10.010
   O'Reilly GA, 2014, OBES REV, V15, P453, DOI 10.1111/obr.12156
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Parker JDA, 2003, J PSYCHOSOM RES, V55, P269, DOI 10.1016/S0022-3999(02)00578-0
   Porcelli P, 2018, ALEXITHYMIA PHYS ILL
   Porcelli P, 2011, J CLIN PSYCHOL, V67, P1177, DOI 10.1002/jclp.20839
   Prefit AB, 2019, APPETITE, V143, DOI 10.1016/j.appet.2019.104438
   Puustinen PJ, 2011, PSYCHOSOM MED, V73, P158, DOI 10.1097/PSY.0b013e3182037315
   Santor DA, 1997, J PERS SOC PSYCHOL, V73, P1354, DOI 10.1037/0022-3514.73.6.1354
   Schumacher R.E., 1996, A beginner's guide to structural equation modeling
   Sepede G, 2011, INT J IMMUNOPATH PH, V24, P1017, DOI 10.1177/039463201102400419
   Sherling DH, 2017, J CARDIOVASC PHARM T, V22, P365, DOI 10.1177/1074248416686187
   Tang F, 2017, PSYCHONEUROENDOCRINO, V77, P112, DOI 10.1016/j.psyneuen.2016.11.025
   Taylor GJ, 2004, PSYCHOTHER PSYCHOSOM, V73, P68, DOI 10.1159/000075537
   Taylor GJ, 2000, CAN J PSYCHIAT, V45, P134, DOI 10.1177/070674370004500203
   Taylor GJ., 1997, DISORDERS AFFECT REG
   Taylor GJ, 2016, NEUROSCI BIOBEHAV R, V68, P1006, DOI 10.1016/j.neubiorev.2016.05.025
   van Vliet-Ostaptchouk JV, 2014, BMC ENDOCR DISORD, V14, DOI 10.1186/1472-6823-14-9
   Weihe P, 2019, CURR OBES REP, V8, P472, DOI 10.1007/s13679-019-00357-x
   Westwood H, 2017, J PSYCHOSOM RES, V99, P66, DOI 10.1016/j.jpsychores.2017.06.007
   World Medical Association, 2013, 64 WMA GEN ASS FORT
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 61
TC 8
Z9 8
U1 1
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1124-4909
EI 1590-1262
J9 EAT WEIGHT DISORD-ST
JI Eat. Weight Disord.-Stud. Anorex.
PD AUG
PY 2021
VL 26
IS 6
BP 1813
EP 1823
DI 10.1007/s40519-020-00964-x
EA SEP 2020
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA TP6JK
UT WOS:000568984700001
PM 32920774
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Stancliffe, RA
   Thorpe, T
   Zemel, MB
AF Stancliffe, Renee A.
   Thorpe, Teresa
   Zemel, Michael B.
TI Dairy attentuates oxidative and inflammatory stress in metabolic
   syndrome
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID INSULIN-RESISTANCE SYNDROME; DIETARY PATTERNS; BLOOD-PRESSURE;
   CARDIOVASCULAR-DISEASE; SYSTEMIC INFLAMMATION; VITAMIN-D; CALCIUM;
   MARKERS; CONSUMPTION; PLASMA
AB Background: Oxidative and inflammatory stress are elevated in obesity and are further augmented in metabolic syndrome. We showed previously that dairy components suppress the adipocyte- and macrophage-mediated generation of reactive oxygen species and inflammatory cytokines and systemic oxidative and inflammatory biomarkers in obesity.
   Objective: The objective of this study was to determine the early (7 d) and sustained (4 and 12 wk) effects of adequate-dairy (AD) compared with low-dairy (LD) diets in subjects with metabolic syndrome.
   Design: Forty overweight and obese adults with metabolic syndrome were randomly assigned to receive AD (3.5 daily servings) or LD (<0.5 daily servings) weight-maintenance diets for 12 wk. Oxidative and inflammatory biomarkers were assessed at 0, 1, 4, and 12 wk as primary outcomes; body weight and composition were measured at 0, 4, and 12 wk as secondary outcomes.
   Results: AD decreased malondialdehyde and oxidized LDL at 7 d (35% and 11%, respectively; P < 0.01), with further decreases by 12 wk. Inflammatory markers were suppressed with intake of AD, with decreases in tumor necrosis factor-alpha at 7 d and further reductions through 12 wk (35%; P < 0.05); decreases in interleukin-6 (21%; P < 0.02) and monocyte chemoattractant protein 1 (14% decrease at 4 wk, 24% decrease at 12 wk; P < 0.05); and a corresponding 55% increase in adiponectin at 12 wk (P < 0.01). LD exerted no effect on oxidative or inflammatory markers. Diet had no effect on body weight; however, AD significantly reduced waist circumference and trunk fat (P < 0.01 for both), and LD exerted no effect.
   Conclusion: An increase in dairy intake attenuates oxidative and inflammatory stress in metabolic syndrome. This trial was registered at clinicaltrials.gov as NCT01266330. Am J Clin Nutr 2011;94:422-30.
C1 [Stancliffe, Renee A.; Thorpe, Teresa; Zemel, Michael B.] Univ Tennessee, Dept Nutr, Knoxville, TN 37996 USA.
C3 University of Tennessee System; University of Tennessee Knoxville
RP Zemel, MB (corresponding author), Univ Tennessee, Dept Nutr, 1215 W Cumberland Ave,Room 229, Knoxville, TN 37996 USA.
EM mzemel@utk.edu
OI Zemel, Michael/0000-0003-4104-5750
FU National Dairy Council
FX Supported by the National Dairy Council and administered by the Dairy
   Research Institute.
CR Choi HK, 2005, ARCH INTERN MED, V165, P997, DOI 10.1001/archinte.165.9.997
   Chrysohoou C, 2004, J AM COLL CARDIOL, V44, P152, DOI 10.1016/j.jacc.2004.03.039
   Dandona P, 2001, J CLIN ENDOCR METAB, V86, P355, DOI 10.1210/jc.86.1.355
   Esmaillzadeh A, 2007, J NUTR, V137, P992, DOI 10.1093/jn/137.4.992
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Festa A, 2001, INT J OBESITY, V25, P1407, DOI 10.1038/sj.ijo.0801792
   FitzGerald RJ, 2000, BRIT J NUTR, V84, pS33
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Kris-Etherton PM, 2009, J AM COLL NUTR, V28, p103S, DOI 10.1080/07315724.2009.10719804
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lopez-Garcia E, 2004, AM J CLIN NUTR, V80, P1029, DOI 10.1093/ajcn/80.4.1029
   Massey LK, 2001, J NUTR, V131, P1875, DOI 10.1093/jn/131.7.1875
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McCarron DA, 2001, AM J HYPERTENS, V14, p206S, DOI 10.1016/S0895-7061(01)02090-8
   Miller ER, 2005, ATHEROSCLEROSIS, V183, P175, DOI 10.1016/j.atherosclerosis.2005.04.001
   Mohanty P, 2000, J CLIN ENDOCR METAB, V85, P2970, DOI 10.1210/jc.85.8.2970
   Nettleton JA, 2006, AM J CLIN NUTR, V83, P1369, DOI 10.1093/ajcn/83.6.1369
   Nilsson M, 2004, AM J CLIN NUTR, V80, P1246, DOI 10.1093/ajcn/80.5.1246
   Pereira MA, 2002, JAMA-J AM MED ASSOC, V287, P2081, DOI 10.1001/jama.287.16.2081
   Pittas AG, 2006, DIABETES CARE, V29, P650, DOI 10.2337/diacare.29.03.06.dc05-1961
   Pittas AG, 2007, J CLIN ENDOCR METAB, V92, P2017, DOI 10.1210/jc.2007-0298
   Savica V, 2010, ANNU REV NUTR, V30, P365, DOI 10.1146/annurev-nutr-010510-103954
   Schulze MB, 2005, AM J CLIN NUTR, V82, P675, DOI 10.1093/ajcn/82.3.675
   Sun X, 2006, INT J OBESITY, V30, P1341, DOI 10.1038/sj.ijo.0803294
   Sun X, 2007, OBESITY, V15, P340, DOI 10.1038/oby.2007.540
   Sun XC, 2007, OBESITY, V15, P1944, DOI 10.1038/oby.2007.232
   van Dam RM, 2006, DIABETES CARE, V29, P2238, DOI 10.2337/dc06-1014
   Van Guilder GP, 2006, OBESITY, V14, P2127, DOI 10.1038/oby.2006.248
   van Meijl LEC, 2010, BRIT J NUTR, V104, P1523, DOI 10.1017/S0007114510002515
   WEIR JBD, 1949, J PHYSIOL-LONDON, V109, P1, DOI 10.1113/jphysiol.1949.sp004363
   Wennersberg MH, 2009, AM J CLIN NUTR, V90, P960, DOI 10.3945/ajcn.2009.27664
   YAGI K, 1976, BIOCHEM MED METAB B, V15, P212, DOI 10.1016/0006-2944(76)90049-1
   Zemel MB, 2008, J NUTR, V138, P1047, DOI 10.1093/jn/138.6.1047
   Zemel MB, 2009, PHYSICIAN SPORTSMED, V37, P29, DOI 10.3810/psm.2009.06.1707
   Zemel MB, 2010, AM J CLIN NUTR, V91, P16, DOI 10.3945/ajcn.2009.28468
NR 37
TC 137
Z9 155
U1 1
U2 19
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD AUG
PY 2011
VL 94
IS 2
BP 422
EP 430
DI 10.3945/ajcn.111.013342
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 794TT
UT WOS:000292924900010
PM 21715516
OA Bronze, Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Weiss, T
   Skelton, K
   Phifer, J
   Jovanovic, T
   Gillespie, CF
   Smith, A
   Umpierrez, G
   Bradley, B
   Ressler, KJ
AF Weiss, Tamara
   Skelton, Kelly
   Phifer, Justine
   Jovanovic, Tanja
   Gillespie, Charles F.
   Smith, Alicia
   Umpierrez, Guillermo
   Bradley, Bekh
   Ressler, Kerry J.
TI Posttraumatic stress disorder is a risk factor for metabolic syndrome in
   an impoverished urban population
SO GENERAL HOSPITAL PSYCHIATRY
LA English
DT Article
DE Posttraumatic stress disorder; Depression; African American; Minority;
   Trauma; Child abuse; Childhood maltreatment; Psychiatry
ID 3RD NATIONAL-HEALTH; CARDIOVASCULAR-DISEASE; TRAUMA EXPOSURE;
   PRIMARY-CARE; SOCIOECONOMIC-STATUS; ALL-CAUSE; PREVALENCE; MORTALITY;
   VETERANS; PTSD
AB Objective: Metabolic syndrome is associated with elevated risk for cardiovascular disease and diabetes and has increased prevalence in low-income African Americans, which constitutes a significant health disparity. The mechanisms responsible for this disparity remain unclear; the current study investigated the relationship between posttraumatic stress disorder (PTSD) and metabolic syndrome.
   Method: We assessed childhood and adult trauma history, major depressive disorder, PTSD and the components of metabolic syndrome in an urban population. We recruited 245 low-socioeconomic-status, primarily African American subjects from general medical clinics in an inner-city hospital.
   Results: Trauma exposure was extremely prevalent, with 90.6% of subjects reporting at least one significant trauma and 18.8% of subjects meeting criteria for current PTSD. Metabolic syndrome was also prevalent in this population (33.2%), with significantly higher rates among patients with current PTSD (47.8%, P <.05). After controlling for demographics, smoking history, antipsychotic use, depression and exercise, current PTSD remained the only significant predictor of metabolic syndrome (P=.006).
   Conclusions: PTSD is associated with increased rates of metabolic syndrome within a traumatized, impoverished urban population. Further studies should investigate if PTSD treatment may reduce the rates of metabolic syndrome, improve overall health outcomes and decrease health care disparities in minority populations. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Weiss, Tamara; Phifer, Justine; Jovanovic, Tanja; Gillespie, Charles F.; Bradley, Bekh; Ressler, Kerry J.] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30329 USA.
   [Smith, Alicia] Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA 30329 USA.
   [Umpierrez, Guillermo] Emory Univ, Sch Med, Dept Med, Atlanta, GA 30329 USA.
   [Ressler, Kerry J.] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA.
   [Skelton, Kelly; Bradley, Bekh] Atlanta VA Med Ctr, Decatur, GA 30033 USA.
   [Ressler, Kerry J.] Yerkes Natl Primate Res Ctr, Atlanta, GA 30322 USA.
C3 Emory University; Emory University; Emory University; Howard Hughes
   Medical Institute; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Atlanta VA Medical Center; Atlanta VA Health Care
   System
RP Ressler, KJ (corresponding author), Emory Univ, Howard Hughes Med Inst, Dept Psychiat & Behav Sci, Yerkes Res Ctr, Atlanta, GA 30329 USA.
EM kressle@emory.edu
RI Smith, Alicia/W-6809-2019; Jovanovic, Tanja/K-4095-2014; Bradley,
   Bekh/H-8399-2012; Gillespie, Charles/G-8481-2012; Ressler,
   Kerry/N-8741-2018
OI Ressler, Kerry/0000-0002-5158-1103; Gillespie,
   Charles/0000-0001-5476-5920
FU NCATS NIH HHS [UL1 TR000454] Funding Source: Medline; NIDDK NIH HHS [K08
   DK083036] Funding Source: Medline; NIMH NIH HHS [R01 MH071537, K23
   MH082256] Funding Source: Medline
CR Alim TN, 2006, J NATL MED ASSOC, V98, P1630
   Appel Susan J, 2006, J Natl Black Nurses Assoc, V17, P47
   Babic D, 2007, PSYCHIAT DANUB, V19, P68
   Binder EB, 2008, JAMA-J AM MED ASSOC, V299, P1291, DOI 10.1001/jama.299.11.1291
   Blake D.D., 1990, The Behavior Therapist, V18, P187, DOI [10.1037/t00072-000, DOI 10.1007/BF02105408]
   BLAKE DD, 1995, J TRAUMA STRESS, V8, P75, DOI 10.1007/BF02105408
   Blevins Lisa P, 2008, J Natl Black Nurses Assoc, V19, P52
   Boscarino JA, 2006, ANN EPIDEMIOL, V16, P248, DOI 10.1016/j.annepidem.2005.03.009
   Boscarino JA, 2004, ANN NY ACAD SCI, V1032, P141, DOI 10.1196/annals.1314.011
   Braunschweig CL, 2005, AM J CLIN NUTR, V81, P970
   Breslau N, 2004, J URBAN HEALTH, V81, P530, DOI 10.1093/jurban/jth138
   Cameron AJ, 2004, ENDOCRIN METAB CLIN, V33, P351, DOI 10.1016/j.ecl.2004.03.005
   Chan PS, 2009, JAMA-J AM MED ASSOC, V302, P1195, DOI 10.1001/jama.2009.1340
   Clark L T, 2001, Heart Dis, V3, P97
   Cook NR, 2009, CLIN CHEM, V55, P1603, DOI 10.1373/clinchem.2009.131185
   Cusack KJ, 2004, PSYCHIAT SERV, V55, P157, DOI 10.1176/appi.ps.55.2.157
   David D, 2004, PSYCHIAT SERV, V55, P82, DOI 10.1176/appi.ps.55.1.82
   Duprez DA, 2009, ETHNIC DIS, V19, P243
   First M.B., 2016, User's Guide for the SCID-5-CV Structured Clinical Interview for DSM-5 Disorders: Clinical Version
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Gaillard T, 2010, METABOLISM, V59, P1115, DOI 10.1016/j.metabol.2009.09.035
   Gander ML, 2006, EUR J CARDIOV PREV R, V13, P165, DOI 10.1097/01.hjr.0000214606.60995.46
   Gillespie CF, 2009, GEN HOSP PSYCHIAT, V31, P505, DOI 10.1016/j.genhosppsych.2009.05.003
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Heppner PS, 2009, BMC MED, V7, DOI 10.1186/1741-7015-7-1
   Hu G, 2004, ARCH INTERN MED, V164, P1066, DOI 10.1001/archinte.164.10.1066
   Hunt KJ, 2004, CIRCULATION, V110, P1251, DOI 10.1161/01.CIR.0000140762.04598.F9
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jakovjevic M, 2007, PSYCHIAT DANUB, V19, P76
   JAKOVLJEVIC M, 2006, PSYCHIAT DANUB, V18, P176
   Jakovljevic M, 2008, PSYCHIAT DANUB, V20, P406
   Jin H, 2009, J CLIN PSYCHOPHARM, V29, P210, DOI 10.1097/JCP.0b013e3181a45ed0
   Kagan BL, 1999, BIOL PSYCHIAT, V45, P374, DOI 10.1016/S0006-3223(98)00059-6
   Kraja AT, 2006, NUTR METAB, V3, DOI 10.1186/1743-7075-3-41
   Krause N, 2004, PSYCHOL AGING, V19, P637, DOI 10.1037/0882-7974.19.4.637
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lehman BJ, 2005, PSYCHOSOM MED, V67, P846, DOI 10.1097/01.psy.0000188443.48405.eb
   Liebschutz J, 2007, J GEN INTERN MED, V22, P719, DOI 10.1007/s11606-007-0161-0
   Link CL, 2009, ETHNIC DIS, V19, P288
   Loucks EB, 2007, ANN EPIDEMIOL, V17, P782, DOI 10.1016/j.annepidem.2007.05.003
   Maia DB, 2008, J AFFECT DISORDERS, V107, P259, DOI 10.1016/j.jad.2007.08.013
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   McEwen BS, 2003, HORM BEHAV, V43, P2, DOI 10.1016/S0018-506X(02)00024-7
   Mensah GA, 2005, CIRCULATION, V111, P1233, DOI 10.1161/01.CIR.0000158136.76824.04
   Newcomer JW, 2005, CNS DRUGS, V19, P1
   Norris F.H., 2004, ASSESSING PSYCHOL TR, V2nd, P63
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Rosmond R, 2005, PSYCHONEUROENDOCRINO, V30, P1, DOI 10.1016/j.psyneuen.2004.05.007
   Salsberry PJ, 2007, AM J PREV MED, V33, P114, DOI 10.1016/j.amepre.2007.03.017
   Schnurr P P, 1999, Semin Clin Neuropsychiatry, V4, P295
   Schwartz AC, 2005, PSYCHIAT SERV, V56, P212, DOI 10.1176/appi.ps.56.2.212
   Seeman TE, 2001, P NATL ACAD SCI USA, V98, P4770, DOI 10.1073/pnas.081072698
   Shonkoff JP, 2009, JAMA-J AM MED ASSOC, V301, P2252, DOI 10.1001/jama.2009.754
   Solter V, 2002, CROAT MED J, V43, P685
   Trief PM, 2006, J BEHAV MED, V29, P411, DOI 10.1007/s10865-006-9067-2
   Vieweg W Victor R, 2006, Prim Care Companion J Clin Psychiatry, V8, P25
   Violanti John M, 2006, Int J Emerg Ment Health, V8, P227
   Weathers FW, 2001, DEPRESS ANXIETY, V13, P132, DOI 10.1002/da.1029
NR 58
TC 64
Z9 79
U1 0
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0163-8343
EI 1873-7714
J9 GEN HOSP PSYCHIAT
JI Gen. Hosp. Psych.
PD MAR-APR
PY 2011
VL 33
IS 2
BP 135
EP 142
DI 10.1016/j.genhosppsych.2011.01.002
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 745RP
UT WOS:000289183700007
PM 21596206
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Vitale, E
AF Vitale, Elsa
TI Correlations between Insomnia and Sex, Work Experience, Shift and Body
   Max Index in Italian Nurses: A Scoping Profile Statement
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Article
DE Body mass index; insomnia; nurse; sex; shift work; workload
ID MENTAL-HEALTH STATUS; METABOLIC SYNDROME; MASS INDEX; HOSPITAL NURSES;
   ENERGY-INTAKE; CARDIOVASCULAR-DISEASE; PHYSICAL INACTIVITY; SEVERITY
   INDEX; MEAL FREQUENCY; HEART-DISEASE
AB Aim The present study aimed to assess any association existing between insomnia according to sex, work experience, shift and BMI values in Italian nurses. Methods An "ad hoc" questionnaire was created and administered online in October 2020. Data collected included: sex, years of work experience, shift work per day, BMI values, and insomnia levels. Findings A total of 341 Italian nurses were enrolled. Of these, 277 (81.23%) were females and n=64 (18.77%) males. No significant differences were assessed between ISI levels and sex, BMI scores, work experience and shift (p=.098; p=.978; p=.561; p=.222, respectively). Significant and inverse correlation was assessed between ISI values and sex (p=.019), BMI values (p=.033). While, no significant correlations were assessed between ISI levels and work experience (p=.805) and shift (p=.962), respectively. However, work experience reported significant correlations between BMI classes (p>.001) and shift (p<.001). Conclusion Data suggested potential health risk factors for the nursing workforce, associated with weight gain and developing Metabolic Syndrome. Therefore, the essence of the nursing profession could affect work performance and cause problems in the family and social life, as well as stress, anxiety, depression, fatigue, and irregular sleep patterns.
C1 [Vitale, Elsa] Local Hlth Author Bari, Ctr Mental Hlth Modugno, Via X Marzo 43, I-70026 Bari, Italy.
RP Vitale, E (corresponding author), Local Hlth Author Bari, Ctr Mental Hlth Modugno, Via X Marzo 43, I-70026 Bari, Italy.
EM vitaleelsa@libero.it
RI Vitale, Elsa/D-8904-2018
OI Vitale, Elsa/0000-0002-9738-3479
CR Alam I, 2011, NUTR J, V10, DOI 10.1186/1475-2891-10-111
   Albougami A, 2019, SLEEP BREATH, V23, P987, DOI 10.1007/s11325-019-01812-8
   Almajwal AM, 2016, SAUDI MED J, V37, P191, DOI 10.15537/smj.2016.2.13060
   [Anonymous], 2010, WHO WHO HLTH WORKPLA
   Antunes LC, 2010, NUTR RES REV, V23, P155, DOI 10.1017/S0954422410000016
   Arimura M, 2010, IND HEALTH, V48, P811, DOI 10.2486/indhealth.MS1093
   Åsberg M, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0003590
   Bastien CH, 2001, SLEEP MED, V2, P297, DOI 10.1016/S1389-9457(00)00065-4
   Blake Holly, 2013, Br J Nurs, V22, P86
   Blake H, 2011, PERSPECT PUBLIC HEAL, V131, P231, DOI 10.1177/1757913911402547
   Bogossian FE, 2012, INT J NURS STUD, V49, P727, DOI 10.1016/j.ijnurstu.2012.01.003
   Brum MCB, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/s13098-015-0041-4
   Cain SW, 2015, SCAND J WORK ENV HEA, V41, P288, DOI 10.5271/sjweh.3486
   Canuto R, 2013, SLEEP MED REV, V17, P425, DOI 10.1016/j.smrv.2012.10.004
   Castronovo V, 2016, NEUROL SCI, V37, P1517, DOI 10.1007/s10072-016-2620-z
   COLE RJ, 1990, OCCUP MED, V5, P301
   Copertaro Alfredo, 2009, Recenti Progressi in Medicina, V100, P502
   de Assis MAA, 2003, J HUM NUTR DIET, V16, P283, DOI 10.1046/j.1365-277X.2003.00448.x
   Deitrick K, 2020, J EMERG NURS, V46, P748, DOI 10.1016/j.jen.2020.07.010
   Deleze C., 2010, THESIS
   Delezie J, 2011, ANN NY ACAD SCI, V1243, P30, DOI 10.1111/j.1749-6632.2011.06246.x
   Deneva T, 2019, MEDICINA-LITHUANIA, V55, DOI 10.3390/medicina55050209
   Di Lorenzo L, 2003, INT J OBESITY, V27, P1353, DOI 10.1038/sj.ijo.0802419
   Escasany M, 2012, REV ESP NUTR HUM DIE, V16, P89
   Fadeyi B. A., 2018, Sleep Sci. Pract, V2, P6, DOI [DOI 10.1186/S41606-018-0027-X, 10.1186/s41606-018-0027-x]
   Faugier J, 2001, Nurs Stand, V15, P33
   Fontanini R, 2021, INT NURS REV, V68, P238, DOI 10.1111/inr.12669
   Forejt M, 2017, CENT EUR J PUBL HEAL, V25, P321, DOI 10.21101/cejph.a4451
   Frost P, 2009, SCAND J WORK ENV HEA, V35, P163, DOI 10.5271/sjweh.1319
   Ghosh A, 2010, PUBLIC HEALTH GENOM, V13, P353, DOI 10.1159/000262330
   Gorin AA, 2004, INT J OBESITY, V28, P278, DOI 10.1038/sj.ijo.0802550
   Grossi G, 2005, J PSYCHOSOM RES, V59, P103, DOI 10.1016/j.jpsychores.2005.02.009
   Guo YF, 2017, PSYCHONEUROENDOCRINO, V77, P47, DOI 10.1016/j.psyneuen.2016.11.020
   Han K, 2016, APPL NURS RES, V30, P38, DOI 10.1016/j.apnr.2015.10.009
   Harbeck B, 2015, J OCCUP HEALTH, V57, P438, DOI 10.1539/joh.14-0276-OA
   Haus E, 2016, CHRONOBIOL INT, V33, P1018, DOI 10.3109/07420528.2016.1167079
   Hecker J, 2022, BMC PUBLIC HEALTH, V22, DOI 10.1186/s12889-021-12449-2
   Heidemann C, 2011, BRIT J NUTR, V106, P1253, DOI 10.1017/S0007114511001504
   Hemmer A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13114178
   HUBERT HB, 1983, CIRCULATION, V67, P968, DOI 10.1161/01.CIR.67.5.968
   Itani O, 2011, SLEEP MED, V12, P341, DOI 10.1016/j.sleep.2010.09.007
   Johnson RK, 2009, CIRCULATION, V120, P1011, DOI 10.1161/CIRCULATIONAHA.109.192627
   Kahleova H, 2017, J NUTR, V147, P1722, DOI 10.3945/jn.116.244749
   Kahleova Hana, 2016, Vnitr Lek, V62, pS15
   Kakiashvili T, 2013, INT J OCCUP MED ENV, V26, P401, DOI 10.2478/s13382-013-0093-3
   Khosravipour M, 2019, DIAB MET SYND CLIN R, V13, P3085, DOI 10.1016/j.dsx.2019.11.006
   Kim SA, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122992
   Knutsson A, 2000, Rev Environ Health, V15, P359
   Kyle RG, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2017-018498
   Lauby-Secretan B, 2016, NEW ENGL J MED, V375, P794, DOI 10.1056/NEJMsr1606602
   Lee JY, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18041854
   Letvak S, 2013, J NURS MANAGE, V21, P914, DOI 10.1111/jonm.12181
   Li YR, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0199293
   Lipinska A, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-75
   Liu SM, 2001, CURR OPIN LIPIDOL, V12, P395, DOI 10.1097/00041433-200108000-00005
   LoGiudice JA, 2021, AACN ADV CRIT CARE, V32, P14, DOI 10.4037/aacnacc2021816
   Lucchini A, 2020, INTENS CRIT CARE NUR, V61, DOI 10.1016/j.iccn.2020.102929
   Lustig RH, 2012, NATURE, V482, P27, DOI 10.1038/482027a
   Makrides L, 2010, HEALTH PROMOT INT, V25, P384, DOI 10.1093/heapro/daq042
   Mattson MP, 2005, ANNU REV NUTR, V25, P237, DOI 10.1146/annurev.nutr.25.050304.092526
   McGlynn N, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0137561
   Melamed S, 2006, PSYCHOL BULL, V132, P327, DOI 10.1037/0033-2909.132.3.327
   Miller SK, 2008, J AM ACAD NURSE PRAC, V20, P259, DOI 10.1111/j.1745-7599.2008.00319.x
   Morikawa Y, 2007, SCAND J WORK ENV HEA, V33, P45, DOI 10.5271/sjweh.1063
   Morin CM, 2009, JAMA-J AM MED ASSOC, V301, P2005, DOI 10.1001/jama.2009.682
   Morin CM., 1993, Insomnia: psychological assessment and management
   Murakami K, 2015, J NUTR, V145, P2715, DOI 10.3945/jn.115.219808
   Must A, 1999, JAMA-J AM MED ASSOC, V282, P1523, DOI 10.1001/jama.282.16.1523
   Nabe-Nielsen K, 2021, OCCUP ENVIRON MED, V78, P248, DOI 10.1136/oemed-2020-106831
   Naidoo R, 2007, Curationis, V30, P66
   Neil-Sztramko SE, 2016, J OCCUP ENVIRON MED, V58, P94, DOI 10.1097/JOM.0000000000000574
   Ostry AS, 2006, BMC PUBLIC HEALTH, V6, DOI 10.1186/1471-2458-6-53
   Pan A, 2011, PLOS MED, V8, DOI 10.1371/journal.pmed.1001141
   Paoli A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11040719
   Peplonska B, 2019, MED PR, V70, P363, DOI 10.13075/mp.5893.00816
   Peplonska B, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0133761
   Perry L, 2015, BMC NURS, V14, DOI 10.1186/s12912-015-0091-9
   Phiri LP, 2014, BMC NURS, V13, DOI 10.1186/s12912-014-0038-6
   Pietroiusti A, 2010, OCCUP ENVIRON MED, V67, P54, DOI 10.1136/oem.2009.046797
   Qiao H, 2020, SLEEP MED, V71, P89, DOI 10.1016/j.sleep.2020.02.016
   Reiter RJ, 2012, ANN MED, V44, P564, DOI 10.3109/07853890.2011.586365
   Rho YH, 2005, J KOREAN MED SCI, V20, P1029, DOI 10.3346/jkms.2005.20.6.1029
   Ricci JA, 2005, J OCCUP ENVIRON MED, V47, P1227, DOI 10.1097/01.jom.0000184871.20901.c3
   Robinson R, 2021, DIMENS CRIT CARE NUR, V40, P156, DOI 10.1097/DCC.0000000000000481
   Rohmer O, 2004, TRAV HUMAIN, V67, P359, DOI 10.3917/th.674.0359
   Rosenbaum DL, 2016, CLIN OBES, V6, P193, DOI 10.1111/cob.12142
   Sahin MK, 2020, J COMMUN HEALTH, V45, P1168, DOI 10.1007/s10900-020-00921-w
   Samhat Z, 2020, BMC NURS, V19, DOI 10.1186/s12912-020-00412-2
   Sangsefidi ZS, 2020, ANN GEN PSYCHIATR, V19, DOI 10.1186/s12991-020-00263-w
   Scheer FAJL, 2009, P NATL ACAD SCI USA, V106, P4453, DOI 10.1073/pnas.0808180106
   Shin S, 2019, APPL PHYSIOL NUTR ME, V44, P1371, DOI 10.1139/apnm-2018-0880
   Shuval K, 2020, J PHYS ACT HEALTH, V17, P1042, DOI 10.1123/jpah.2019-0645
   Shuval K, 2014, BRIT J SPORT MED, V48, P250, DOI 10.1136/bjsports-2013-092901
   Skaal L, 2011, S AFR FAM PRACT, V53, P563, DOI 10.1080/20786204.2011.10874153
   Sonnentag S, 2006, SCAND J WORK ENV HEA, V32, P333, DOI 10.5271/sjweh.1028
   Stanojevic Cedomirka, 2016, Med Pregl, V69, P183
   Stubbs Richard James, 2013, BMC Res Notes, V6, P161, DOI 10.1186/1756-0500-6-161
   Suliga E, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112764
   Surani Salim, 2007, Nurs Adm Q, V31, P146
   Suwazono Y, 2008, OBESITY, V16, P1887, DOI 10.1038/oby.2008.298
   Suzuki K, 2004, J OCCUP HEALTH, V46, P448, DOI 10.1539/joh.46.448
   Sweeney E, 2020, INT ARCH OCC ENV HEA, V93, P67, DOI 10.1007/s00420-019-01459-8
   Tanaka K, 2010, CHRONOBIOL INT, V27, P1895, DOI 10.3109/07420528.2010.516045
   Terada T, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092054
   Tims M, 2013, J OCCUP HEALTH PSYCH, V18, P230, DOI 10.1037/a0032141
   Torquati L, 2018, SCAND J WORK ENV HEA, V44, P229, DOI 10.5271/sjweh.3700
   Tsou MT, 2021, J OCCUP HEALTH, V63, DOI 10.1002/1348-9585.12188
   van Amelsvoort LGMP, 1999, INT J OBESITY, V23, P973, DOI 10.1038/sj.ijo.0801028
   Vannabouathong C, 2020, J BONE JOINT SURG AM, V102, P734, DOI 10.2106/JBJS.20.00396
   Veqar Zubia, 2017, Int J Adolesc Med Health, V32, DOI 10.1515/ijamh-2016-0090
   Vetter C, 2016, JAMA-J AM MED ASSOC, V315, P1726, DOI 10.1001/jama.2016.4454
   Vitale E, 2021, PROG NUTR, V23, DOI 10.23751/pn.v23i2.9090
   Vitale E, 2021, J HOLIST NURS, V39, P345, DOI 10.1177/08980101211015804
   Vitale Elsa, 2021, Acta Biomed, V92, pe2021007, DOI 10.23750/abm.v92iS2.11305
   Vitale E, 2020, MINERVA PSICH, V61, P162, DOI 10.23736/S0391-1772.20.02090-7
   Vitale Elsa, 2020, Acta Biomed, V91, pe2020117, DOI 10.23750/abm.v91i4.9008
   Vitale E, 2021, ENDOCR METAB IMMUNE, V21, P1982, DOI 10.2174/1871530321666210114154401
   Vitale E, 2021, ENDOCR METAB IMMUNE, V21, P1604, DOI 10.2174/1871530320666201016150033
   Vitale E, 2014, ENDOCR METAB IMMUNE, V14, P93, DOI 10.2174/1871530314666140307095630
   Wyse CA, 2017, ANN MED, V49, P411, DOI 10.1080/07853890.2017.1292045
   Yeh CJ, 2011, ASIA PAC J CLIN NUTR, V20, P292
   Yeh WC, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000011664
   Zhang CX, 2020, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.00306
   Zhang Q, 2020, INT J NURS STUD, V112, DOI 10.1016/j.ijnurstu.2020.103757
   Zhang SK, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18126355
NR 125
TC 3
Z9 3
U1 0
U2 6
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2022
VL 22
IS 13
BP 1303
EP 1312
DI 10.2174/1871530322666220701095751
PG 10
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA 7A9MU
UT WOS:000898771900008
PM 35786343
DA 2025-06-11
ER

PT J
AU Adewuya, AO
   Oladipo, O
   Ajomale, T
   Adewumi, T
   Momodu, O
   Olibamoyo, O
   Adesoji, O
   Adegbokun, A
   Adegbaju, D
AF Adewuya, Abiodun O.
   Oladipo, Olabisi
   Ajomale, Tolu
   Adewumi, Tomilola
   Momodu, Olufisayo
   Olibamoyo, Olushola
   Adesoji, Olabanji
   Adegbokun, Adedayo
   Adegbaju, Dapo
TI Epidemiology of depression in primary care: Findings from the Mental
   Health in Primary Care (MeHPriC) project, Lagos, Nigeria
SO INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE
LA English
DT Article
DE rate; correlates; epidemiology; depression; primary care; Nigeria
ID ALCOHOL-RELATED PROBLEMS; SOCIAL SUPPORT; SCREENING TOOL; AGE;
   QUESTIONNAIRE; POPULATION; PREVALENCE; SEVERITY; SYMPTOMS; METAANALYSIS
AB Objective
   To estimate the rate and correlates of depression in primary care using data from the Mental Health in Primary Care (MeHPriC) project, Lagos, Nigeria.
   Methods
   Adult attendees (n=44,238) of 57 primary care facilities were evaluated for depression using the Patient Health Questionnaire (PHQ-9). Apart from the socio-demographic details, information was also collected regarding the use of alcohol and other psychoactive substances, presence of chronic medical problems, level of functionality, and perceived social support. Anthropometrics measures (weight and height) and blood pressure were also recorded.
   Results
   A total of 27,212 (61.5%) of the participants were females. There were 32,037 (72.4%) participants in the age group 25-60 years. The rate of major depression (PHQ-9 score 10 and above) was 15.0% (95% CI 14.6-15.3). The variables independently associated with depression include age 18-24 years (OR 1.69), female sex (OR 2.39), poor social support (OR 1.14), having at least one metabolic syndrome component (OR 1.57), significant alcohol use (OR 1.13) and functional disability (OR 1.38).
   Conclusion
   Our study showed that the rate of depression in primary care in Nigeria is high. Screening for all primary care attendees for depression will be an important step towards scaling up mental health services in Nigeria and other developing countries.
C1 [Adewuya, Abiodun O.; Olibamoyo, Olushola] Lagos State Univ, Coll Med, Dept Behav Med, Lagos, Nigeria.
   [Adewuya, Abiodun O.; Oladipo, Olabisi; Adewumi, Tomilola; Momodu, Olufisayo] Ctr Mental Hlth Res & Initiat, Lagos, Nigeria.
   [Ajomale, Tolu] Lagos State Minist Hlth, Mental Hlth Desk Off, Lagos, Nigeria.
   [Momodu, Olufisayo; Adesoji, Olabanji; Adegbokun, Adedayo] Lagos State Minist Hlth, Hlth Serv Commiss, Lagos, Nigeria.
   [Adegbaju, Dapo] Fed Neuropsychiat Hosp, Lagos, Nigeria.
C3 Lagos State University
RP Adewuya, AO (corresponding author), Lagos State Univ, Coll Med, Dept Behav Med, Lagos, Nigeria.
EM abiodun.adewuya@lasucom.edu.ng
RI Olibamoyo, Olushola/ABC-8818-2020; ADEWUYA, Abiodun
   Olugbenga/N-4997-2017
OI Oladipo, Olabisi Eniola/0000-0001-7284-7743; Olibamoyo,
   Olushola/0000-0001-9696-029X; ADEWUYA, Abiodun
   Olugbenga/0000-0002-7611-6953
FU Grand Challenges Canada [0796-05]; MRC [MR/T021845/1] Funding Source:
   UKRI
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by Grand Challenges Canada (grant no. 0796-05).
CR Abiola T., 2013, Malaysian J Psychiatry, V22, P32
   Adewuya AO, 2006, J AFFECT DISORDERS, V96, P89, DOI 10.1016/j.jad.2006.05.021
   Adewuya AO, 2019, GEN HOSP PSYCHIAT, V60, P76, DOI 10.1016/j.genhosppsych.2019.07.012
   Adewuya AO, 2019, J AFFECT DISORDERS, V253, P118, DOI 10.1016/j.jad.2019.04.025
   Adewuya AO, 2019, PSYCHOL MED, V49, P2149, DOI 10.1017/S0033291718002970
   Adewuya AO, 2018, COMPR PSYCHIAT, V81, P60, DOI 10.1016/j.comppsych.2017.11.010
   Adewuya AO, 2017, GEN HOSP PSYCHIAT, V47, P1, DOI 10.1016/j.genhosppsych.2017.04.002
   Adewuya AO, 2005, ALCOHOL ALCOHOLISM, V40, P575, DOI 10.1093/alcalc/agh197
   Afolabi MO, 2008, S AFR FAM PRACT, V50, P63, DOI 10.1080/20786204.2008.10873701
   Åhlin J, 2015, BMC PUBLIC HEALTH, V15, DOI 10.1186/s12889-015-1837-8
   Amoran O, 2007, AUST J RURAL HEALTH, V15, P211, DOI 10.1111/j.1440-1584.2006.00794.x
   [Anonymous], 2016, POP CENS LAG STAT
   Bush K, 1998, ARCH INTERN MED, V158, P1789, DOI 10.1001/archinte.158.16.1789
   Chao SF, 2014, AGING MENT HEALTH, V18, P767, DOI 10.1080/13607863.2013.878308
   Dalgard OS, 2006, SOC PSYCH PSYCH EPID, V41, P444, DOI 10.1007/s00127-006-0051-5
   de Wit L, 2010, PSYCHIAT RES, V178, P230, DOI 10.1016/j.psychres.2009.04.015
   Faith MS, 2011, OBES REV, V12, pe438, DOI 10.1111/j.1467-789X.2010.00843.x
   Fekadu A., 2020, UNDER DETECTION DEPR, DOI [10.1101/2020.03/20.20039628, DOI 10.1101/2020.03/20.20039628]
   Ferrari AJ, 2013, PSYCHOL MED, V43, P471, DOI 10.1017/S0033291712001511
   Friedrich M J, 2017, JAMA, V317, P1517, DOI 10.1001/jama.2017.3826
   Gariépy G, 2016, BRIT J PSYCHIAT, V209, P286, DOI 10.1192/bjp.bp.115.169094
   GBD, 2015, LANCET, V388, P10053
   Girgus JS, 2015, CURR OPIN PSYCHOL, V4, P53, DOI 10.1016/j.copsyc.2015.01.019
   Gluszek S, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0235121
   Hirschtritt ME, 2018, J AM BOARD FAM MED, V31, P724, DOI 10.3122/jabfm.2018.05.180092
   Iloh GUP, 2018, NIGER POSTGRAD MED J, V25, P204, DOI 10.4103/npmj.npmj_107_18
   Jorm AF, 2000, PSYCHOL MED, V30, P11, DOI 10.1017/S0033291799001452
   KESSLER RC, 1992, PSYCHOL AGING, V7, P119, DOI 10.1037/0882-7974.7.1.119
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Löwe B, 2005, J PSYCHOSOM RES, V58, P163, DOI 10.1016/j.jpsychores.2004.09.006
   Mattei G, 2018, J NERV MENT DIS, V206, P316, DOI 10.1097/NMD.0000000000000807
   Milaneschi Yuri, 2019, Mol Psychiatry, V24, P18, DOI 10.1038/s41380-018-0017-5
   MIROWSKY J, 1992, J HEALTH SOC BEHAV, V33, P187, DOI 10.2307/2137349
   Mitchell AJ, 2009, LANCET, V374, P609, DOI 10.1016/S0140-6736(09)60879-5
   Obadeji Adetunji, 2015, J Family Med Prim Care, V4, P30, DOI 10.4103/2249-4863.152246
   Ogunsemi OO, 2010, MENT ILLN, V2, DOI 10.4081/mi.2010.e10
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pfaff JJ, 2009, MED J AUSTRALIA, V190, pS75, DOI 10.5694/j.1326-5377.2009.tb02475.x
   Segel-Karpas D, 2017, HEALTH PSYCHOL, V36, P848, DOI 10.1037/hea0000542
   Shittu R O., 2014, Open Journal of Depression, V3, P18, DOI DOI 10.4236/OJD.2014.31006
   Stordal E, 2003, ACTA PSYCHIAT SCAND, V107, P132, DOI 10.1034/j.1600-0447.2003.02056.x
   Ustun T B, 2000, J Gend Specif Med, V3, P54
   Ustun Tevfik Bedirhan, 1994, International Review of Psychiatry, V6, P357, DOI 10.3109/09540269409023273
   Wang XM, 2014, INT J MENT HEALTH SY, V8, DOI 10.1186/1752-4458-8-41
   World Health Organization, 2017, Global Hepatitis Report 2017
   ,, 2010, Measuring health and disability: manual for WHO Disability Assessment Schedule (WHODAS 2.0)
NR 46
TC 2
Z9 2
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0091-2174
EI 1541-3527
J9 INT J PSYCHIAT MED
JI Int. J. Psychiatr. Med.
PD JAN
PY 2022
VL 57
IS 1
BP 6
EP 20
AR 0091217421996089
DI 10.1177/0091217421996089
EA FEB 2021
PG 15
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA XN5LT
UT WOS:000619956100001
PM 33573444
DA 2025-06-11
ER

PT J
AU Stanton, R
   Gaskin, CJ
   Happell, B
   Platania-Phung, C
AF Stanton, Robert
   Gaskin, Cadeyrn J.
   Happell, Brenda
   Platania-Phung, Chris
TI The need for waist circumference as a criterion for metabolic syndrome
   in people with mental illness
SO COLLEGIAN
LA English
DT Article
DE Cardiometabolic health; Mental health; Metabolic health; Monitoring;
   Physical health
ID PHYSICAL HEALTH-CARE; CONSUMERS; NURSES; PREVALENCE; DISORDERS; RISK
AB Central obesity is a risk factor for metabolic syndrome, but taking waist circumference measurements can be uncomfortable for psychiatric inpatient clinicians and consumers, and if often avoided. The objective of this study was to assess whether metabolic syndrome in people with mental illness can be diagnosed without using waist circumference measurements. This study involved a retrospective file audit of metabolic monitoring forms stored in consumers' electronic health records of community-based and inpatient mental health consumers at a mental health service located in regional Queensland, Australia. Of the 721 consumer files audited, 261 included a metabolic monitoring form. Of these 261 forms, 74 contained data on all five criteria for metabolic syndrome and the population-specific criteria for waist circumference was met in 54 (73%) of cases. Metabolic syndrome was detected in 39 consumers and waist circumference was necessary for this diagnosis in 12 (31%) cases. Measurement of waist circumference is, therefore, necessary for the detection of metabolic syndrome for a substantial proportion of consumers. The common practice of avoiding waist circumference measurements clearly needs to change if the physical health needs of consumers are to be adequately addressed. (C) 2016 Australian College of Nursing Ltd. Published by Elsevier Ltd.
C1 [Stanton, Robert; Gaskin, Cadeyrn J.] Cent Queensland Univ, Sch Med & Appl Sci, Rockhampton, Qld, Australia.
   [Gaskin, Cadeyrn J.] Gaskin Res, Melbourne, Vic, Australia.
   [Happell, Brenda] Univ Canberra, SYNERGY Nursing & Midwifery Res Ctr, Canberra, ACT, Australia.
   [Happell, Brenda; Platania-Phung, Chris] ACT Hlth, Canberra, ACT, Australia.
   [Platania-Phung, Chris] Univ Canberra, Fac Hlth, SYNERGY Nursing & Midwifery Res Ctr, Canberra, ACT, Australia.
C3 Central Queensland University; University of Canberra; ACT Health
   Australia; University of Canberra
RP Stanton, R (corresponding author), Cent Queensland Univ, Sch Med & Appl Sci, Bruce Highway, North Rockhampton, Qld 4702, Australia.
EM r.stanton@cqu.edu.au
RI Stanton, Rob/AAJ-5157-2020; Happell, Brenda/HSI-0570-2023
OI Gaskin, Cadeyrn/0000-0001-5240-4320; Stanton,
   Robert/0000-0002-6684-5087; Happell, Brenda/0000-0002-7293-6583
FU Queensland Centre for Social Science Innovation; Central Queensland
   Mental Health Service
FX The authors acknowledge the funding provided by the (former) Queensland
   Centre for Social Science Innovation.Special thanks to Central
   Queensland Mental Health Service for their support of the research, and
   particularly to Karen-Lee O'Brien for undertaking the data entry.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Barber J, 2014, COMMUNITY MENT HLT J, V50, P68, DOI 10.1007/s10597-012-9590-2
   Beltrán-Sánchez H, 2013, J AM COLL CARDIOL, V62, P697, DOI 10.1016/j.jacc.2013.05.064
   Brunero S, 2009, INT J MENT HEALTH NU, V18, P144, DOI 10.1111/j.1447-0349.2009.00595.x
   Cameron AJ, 2004, ENDOCRIN METAB CLIN, V33, P351, DOI 10.1016/j.ecl.2004.03.005
   Coyle D., 2011, J PSYCHIAT INTENSIVE, V7, P79
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   Deng C, 2013, ENDOCRIN METAB CLIN, V42, P545, DOI 10.1016/j.ecl.2013.05.006
   Eapen V, 2013, AUST NZ J PSYCHIAT, V47, P435, DOI 10.1177/0004867412463169
   Galletly CA, 2012, AUST NZ J PSYCHIAT, V46, P753, DOI 10.1177/0004867412453089
   Happell B, 2011, J PSYCHIATR MENT HLT, V18, P706, DOI 10.1111/j.1365-2850.2010.01666.x
   Happell B, 2014, J CLIN NURS, V23, P1018, DOI 10.1111/jocn.12371
   Happell B, 2014, ISSUES MENT HEALTH N, V35, P114, DOI 10.3109/01612840.2013.842619
   Happell B, 2013, NURS EDUC TODAY, V33, P396, DOI 10.1016/j.nedt.2013.01.015
   Happell B, 2012, INT J MENT HEALTH NU, V21, P202, DOI 10.1111/j.1447-0349.2011.00799.x
   Holt R. I., 2015, ACTA PSYCHIAT SCANDI
   Lopresti AL, 2013, PROG NEURO-PSYCHOPH, V45, P92, DOI 10.1016/j.pnpbp.2013.05.005
   Marazziti D, 2013, CNS SPECTRUMS, V18, P6, DOI 10.1017/S1092852912000740
   McKenna B, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/s12888-014-0234-7
   Millar F, 2014, INT J MENT HEALTH NU, V23, P479, DOI 10.1111/inm.12085
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Morgan VA, 2014, PSYCHOL MED, V44, P2163, DOI 10.1017/S0033291713002973
   NSW Health, 2012, MET MON NEW MENT HLT
   Organ B, 2010, AUSTRALAS PSYCHIATRY, V18, P456, DOI 10.3109/10398562.2010.506217
   Robson D, 2007, INT J NURS STUD, V44, P457, DOI 10.1016/j.ijnurstu.2006.07.013
   Robson D, 2012, INT J NURS STUD, V49, P72, DOI 10.1016/j.ijnurstu.2011.07.011
   Rosenbaum S., 2014, INT J MENTAL HLTH NU
   Stanley SH, 2011, AUST NZ J PSYCHIAT, V45, P824, DOI 10.3109/00048674.2011.614591
   Verhaeghe N, 2011, J PSYCHIATR MENT HLT, V18, P487, DOI 10.1111/j.1365-2850.2011.01692.x
   Wang J, 2003, AM J CLIN NUTR, V77, P379, DOI 10.1093/ajcn/77.2.379
NR 30
TC 4
Z9 4
U1 0
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1322-7696
EI 1876-7575
J9 COLLEGIAN
JI Collegian
PY 2017
VL 24
IS 4
BP 387
EP 390
DI 10.1016/j.colegn.2016.08.005
PG 4
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA FB4GI
UT WOS:000406099300010
DA 2025-06-11
ER

PT J
AU Moreira, FP
   Jansen, K
   Cardoso, TD
   Mondin, TC
   Vieira, IS
   Magalhaes, PVD
   Kapczinski, F
   Souza, LDD
   da Silva, RA
   Oses, JP
   Wiener, CD
AF Moreira, Fernanda Pedrotti
   Jansen, Karen
   Cardoso, Taiane de Azevedo
   Mondin, Thaise Campos
   Vieira, Igor Soares
   da Silva Magalhaes, Pedro Vieira
   Kapczinski, Flavio
   de Mattos Souza, Luciano Dias
   da Silva, Ricardo Azevedo
   Oses, Jean Pierre
   Wiener, Carolina David
TI Metabolic syndrome, depression and anhedonia among young adults
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Depression; Anhedonia; Metabolic syndrome
ID BIOLOGICAL RHYTHMS; GENDER-DIFFERENCES; DISORDER; METAANALYSIS;
   COMMUNITY; BIPOLAR; STRESS; ASSOCIATION; PREVALENCE; MORTALITY
AB The aim of this study was to assess the association between anhedonia and metabolic syndrome (MetS) in a well-characterized community sample of individuals with a current depressive episode. This is a cross-sectional study with young adults aged 24-30 years old. Depressive episode and the presence of anhedonia was assessed using the Mini International Neuropsychiatric Interview - Plus version (MINI Plus). The MetS was assessed using the National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATP III). The sample included 931 subjects, being 22 had depression without anhedonia, whereas 55 had depression with anhedonia. MetS was more prevalent among subjects with depression and anhedonia (43.6%) when compared to individuals without anhedonia and population control group. Moreover, subjects with depression and anhedonia have a significant increase of levels of glucose, triglycerides, total-cholesterol and LDL-cholesterol, as well as significant decreased in the HDL-cholesterol level. The present study showed that individuals with depression and anhedonia present higher prevalence of MetS. Our study suggests that the use of the concept of anhedonia may contribute to a better understanding of the complex relationship between depression and metabolic syndrome.
C1 [Moreira, Fernanda Pedrotti; Jansen, Karen; Mondin, Thaise Campos; Vieira, Igor Soares; de Mattos Souza, Luciano Dias; da Silva, Ricardo Azevedo; Oses, Jean Pierre; Wiener, Carolina David] Univ Catolica Pelotas, Dept Hlth & Behav, Translat Sci Brain Disorders, Pelotas, RS, Brazil.
   [Jansen, Karen; Cardoso, Taiane de Azevedo; da Silva Magalhaes, Pedro Vieira; Kapczinski, Flavio] Univ Fed Rio Grande do Sul, Dept Psychiat & Behav Sci, Mol Psychiat, Porto Alegre, RS, Brazil.
   [Kapczinski, Flavio] McMaster Univ, Hamilton, ON, Canada.
   [Wiener, Carolina David] Univ Fed Pelotas, Dept Epidemiol, Pelotas, RS, Brazil.
C3 Universidade Catolica de Pelotas; Universidade Federal de Pelotas;
   Universidade Federal do Rio Grande do Sul; McMaster University;
   Universidade Federal de Pelotas
RP Jansen, K (corresponding author), Univ Catolica Pelotas, Dept Hlth & Behav, Translat Sci Brain Disorders, Pelotas, RS, Brazil.
EM karen.jansen@pq.cnpq.br
RI Cardoso, Taiane/K-1980-2015; Pedrotti Moreira, Fernanda/JRX-8306-2023;
   Oses, Jean/E-2534-2013; Magalhaes, Pedro/A-8519-2008; Jansen,
   Karen/O-3128-2015; Kapczinski, Flavio/D-3175-2013
OI Magalhaes, Pedro/0000-0002-5644-6357; Soares Vieira,
   Igor/0000-0002-3263-8397; Dias de Mattos Souza,
   Luciano/0000-0001-9965-4837; Oses, Jean Pierre/0000-0002-2012-273X;
   Jansen, Karen/0000-0003-3494-8070; Pedrotti Moreira,
   Fernanda/0000-0002-3672-7231; Kapczinski, Flavio/0000-0001-8738-856X
FU Brazilian governamental agency: Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior (CAPES); Brazilian governamental agency:
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq);
   Brazilian governamental agency: Fundacao de Amparo a Pesquisa do Estado
   do Rio Grande do Sul (FAPERGS)
FX Support for this study was provided by Brazilian governamental agencies:
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES),
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) and
   Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS).
CR Amorim P, 1998, EUR PSYCHIAT, V13, P26, DOI 10.1016/S0924-9338(97)86748-X
   [Anonymous], CRITICAL PATHWAYS CA
   [Anonymous], 2013, DIAGNOSTIC STAT MANU, VFifth, P1000
   Brinkmann K, 2009, INT J PSYCHOPHYSIOL, V74, P250, DOI 10.1016/j.ijpsycho.2009.09.009
   Cardoso TD, 2015, J AFFECT DISORDERS, V187, P179, DOI 10.1016/j.jad.2015.08.046
   Cyrus S.H., 2014, Advances in Psychiatric Treatment, V20, P101, DOI 10.1192/apt.bp.113.011619
   Davidson KW, 2010, ARCH GEN PSYCHIAT, V67, P480, DOI 10.1001/archgenpsychiatry.2010.36
   de Oliveira A, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-141
   Der-Avakian A, 2012, TRENDS NEUROSCI, V35, P68, DOI 10.1016/j.tins.2011.11.005
   Dillon DG, 2014, DEPRESS ANXIETY, V31, P233, DOI 10.1002/da.22202
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Epel E, 2001, PSYCHONEUROENDOCRINO, V26, P37, DOI 10.1016/S0306-4530(00)00035-4
   Faria AD, 2015, J AFFECT DISORDERS, V186, P145, DOI 10.1016/j.jad.2015.07.004
   Gheshlagh RG, 2016, IRAN RED CRESCENT ME, V18, DOI 10.5812/ircmj.26523
   Henrique Iara Ferraz Silva, 2004, Rev. Assoc. Med. Bras., V50, P199, DOI 10.1590/S0104-42302004000200039
   Humeniuk R, 2008, ADDICTION, V103, P1039, DOI 10.1111/j.1360-0443.2007.02114.x
   Hyman SE, 2003, SCIENCE, V299, P350, DOI 10.1126/science.1077141
   Ibrahim M, 2016, EAT BEHAV, V21, P214, DOI 10.1016/j.eatbeh.2016.03.009
   Jansen K, 2011, J AFFECT DISORDERS, V130, P328, DOI 10.1016/j.jad.2010.10.007
   Kanoski SE, 2011, PHYSIOL BEHAV, V103, P59, DOI 10.1016/j.physbeh.2010.12.003
   Keränen AM, 2010, APPETITE, V55, P726, DOI 10.1016/j.appet.2010.08.012
   Komulainen T, 2011, INT J CIRCUMPOL HEAL, V70, P72, DOI 10.3402/ijch.v70i1.17795
   Lally N, 2015, J PSYCHOPHARMACOL, V29, P596, DOI 10.1177/0269881114568041
   Leach LS, 2008, SOC PSYCH PSYCH EPID, V43, P983, DOI 10.1007/s00127-008-0388-z
   Lehto SM, 2008, ANN EPIDEMIOL, V18, P871, DOI 10.1016/j.annepidem.2008.07.005
   Mancia G, 2007, BLOOD PRESSURE, V16, P135, DOI 10.1080/08037050701461084
   Martinac M, 2014, ACTA CLIN CROAT, V53, P55
   Moreira FP, 2016, PSYCHONEUROENDOCRINO, V72, P34, DOI 10.1016/j.psyneuen.2016.06.007
   Nefs G, 2016, BRIT J PSYCHIAT, V209, P142, DOI 10.1192/bjp.bp.114.154781
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pelizza Lorenzo, 2009, Ann Gen Psychiatry, V8, P22, DOI 10.1186/1744-859X-8-22
   Satterthwaite TD, 2015, NEUROPSYCHOPHARMACOL, V40, P2258, DOI 10.1038/npp.2015.75
   Shimamoto A, 2015, PSYCHOPHARMACOLOGY, V232, P825, DOI 10.1007/s00213-014-3725-9
   Spijker J, 2001, ACTA PSYCHIAT SCAND, V103, P122, DOI 10.1034/j.1600-0447.2001.103002122.x
   Thomsen KR, 2015, FRONT BEHAV NEUROSCI, V9, DOI 10.3389/fnbeh.2015.00049
   Van de Velde S, 2010, SOC SCI MED, V71, P305, DOI 10.1016/j.socscimed.2010.03.035
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vancampfort D, 2015, DEPRESS ANXIETY, V32, P763, DOI 10.1002/da.22387
   WHO, 2008, WAIST CIRCUMFERENCE
NR 39
TC 41
Z9 46
U1 1
U2 23
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD JAN
PY 2019
VL 271
BP 306
EP 310
DI 10.1016/j.psychres.2018.08.009
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HO1YZ
UT WOS:000460709900048
PM 30522000
DA 2025-06-11
ER

PT J
AU Wilhite, K
   Booker, B
   Huang, BH
   Antczak, D
   Corbett, L
   Parker, P
   Noetel, M
   Rissel, C
   Lonsdale, C
   Cruz, BD
   Sanders, T
AF Wilhite, Katrina
   Booker, Bridget
   Huang, Bo-Huei
   Antczak, Devan
   Corbett, Lucy
   Parker, Philip
   Noetel, Michael
   Rissel, Chris
   Lonsdale, Chris
   Cruz, Borja del Pozo
   Sanders, Taren
TI Combinations of Physical Activity, Sedentary Behavior, and Sleep
   Duration and Their Associations With Physical, Psychological, and
   Educational Outcomes in Children and Adolescents: A Systematic Review
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Review
DE adolescents; children; physical activity; sedentary behavior; sleep
ID 24-HOUR MOVEMENT GUIDELINES; QUALITY-OF-LIFE; CARDIOMETABOLIC
   RISK-FACTORS; POPULATION-BASED SAMPLE; SCHOOL-AGED CHILDREN; SCREEN
   TIME; CARDIORESPIRATORY FITNESS; ACADEMIC-ACHIEVEMENT; MENTAL-HEALTH;
   EUROPEAN ADOLESCENTS
AB We conducted a systematic review to evaluate combinations of physical activity, sedentary behavior, and sleep duration (defined as "movement behaviors") and their associations with physical, psychological, and educational outcomes in children and adolescents. MEDLINE, CINAHL, PsychInfo, SPORTDiscus, PubMed, EMBASE, and ERIC were searched in June 2020. Included studies needed to 1) quantitatively analyze the association of 2 or more movement behaviors with an outcome, 2) analyze a population between 5 and 17 years of age, and 3) include at least an English abstract. We included 141 studies. Most studies included the combination of physical activity and sedentary behavior in their analyses. Sleep was studied less frequently. In combination, a high level of physical activity and a low level of sedentary behavior were associated with the best physical health, psychological health, and education-related outcomes. Sleep was often included in the combination that was associated with the most favorable outcomes. Sedentary behavior had a stronger influence in adolescents than in children and tended to be associated more negatively with outcomes when it was defined as screen time than when defined as overall time spent being sedentary. More initiatives and guidelines combining all 3 movement behaviors will provide benefit with regard to adiposity, cardiometabolic risk factors, cardiorespiratory fitness, muscular physical fitness, well-being, health-related quality of life, mental health, academic performance, and cognitive/executive function.
C1 [Sanders, Taren] Australian Catholic Univ, Inst Posit Psychol & Educ, Fac Hlth Sci, 33 Berry St, North Sydney, NSW 2066, Australia.
   [Wilhite, Katrina; Booker, Bridget; Parker, Philip; Lonsdale, Chris; Sanders, Taren] Australian Catholic Univ, Inst Posit Psychol & Educ, Fac Hlth Sci, North Sydney, NSW, Australia.
   [Huang, Bo-Huei] Univ Sydney, Fac Med & Hlth, Charles Perkins Ctr, Sch Hlth Sci, Sydney, NSW, Australia.
   [Antczak, Devan] Univ Wollongong, Fac Social Sci, Sch Educ, Wollongong, NSW, Australia.
   [Corbett, Lucy] Univ Sydney, Fac Med & Hlth Sci, Sch Publ Hlth, Sydney, NSW, Australia.
   [Noetel, Michael] Australian Catholic Univ, Inst Posit Psychol & Educ, Fac Hlth Sci, Sch Behav & Hlth Sci, North Sydney, NSW, Australia.
   [Rissel, Chris] Flinders Univ S Australia, Coll Med & Publ Hlth, Flinders Northern Terr, Bedford Pk, SA, Australia.
   [Cruz, Borja del Pozo] Univ Southern Denmark, Fac Hlth Sci, Dept Sport Sci & Clin Biomech, Ctr Act & Hlth Aging, Odense, Denmark.
C3 Australian Catholic University; Australian Catholic University - North
   Sydney Campus; Australian Catholic University; Australian Catholic
   University - North Sydney Campus; University of Sydney; University of
   Wollongong; University of Sydney; Australian Catholic University;
   Australian Catholic University - North Sydney Campus; Flinders
   University South Australia; University of Southern Denmark
RP Sanders, T (corresponding author), Australian Catholic Univ, Inst Posit Psychol & Educ, Fac Hlth Sci, 33 Berry St, North Sydney, NSW 2066, Australia.
EM katrina.wilhite@acu.edu.au; bridget.booker@acu.edu.au;
   bhua7802@uni.sydney.edu.au; devan@uow.edu.au;
   lucy.corbett@sydney.edu.au; philip.parker@acu.edu.au;
   michael.noetel@acu.edu.au; chris.rissel@flinders.edu.au;
   chris.lonsdale@acu.edu.au; bdelpozocruz@health.sdu.dk;
   taren.sanders@acu.edu.au
RI Noetel, Michael/I-4534-2019; Rissel, Chris/ABA-5881-2020; Corbett,
   Lucy/AHB-2418-2022; Parker, Philip/K-2896-2018; Huang,
   Bo-Huei/ABD-7382-2020; Lonsdale, Chris/T-8710-2017; Sanders,
   Taren/N-9511-2018; del Pozo Cruz, Borja/IAM-4325-2023
OI Booker, Bridget/0000-0002-8815-7314; Lonsdale,
   Chris/0000-0002-2523-5565; Huang, Bo-Huei/0000-0001-8543-3152; Rissel,
   Chris/0000-0002-2156-8581; Sanders, Taren/0000-0002-4504-6008; Corbett,
   Lucy/0000-0002-6324-4489; del Pozo Cruz, Borja/0000-0003-3944-2212
CR Aggio D, 2016, AM J EPIDEMIOL, V183, P1075, DOI 10.1093/aje/kww031
   Aggio D, 2015, INT J BEHAV NUTR PHY, V12, DOI 10.1186/s12966-015-0249-6
   Agostinis-Sobrinho C., 2018, DIABETES CARE, V18, P543
   Anokye NK, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-624
   [Anonymous], 1995, Bull World Health Organ, V73, P135
   Bai Y, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0148038
   Behm DG, 2008, APPL PHYSIOL NUTR ME, V33, P547, DOI 10.1139/H08-020
   Bergmann GG., 2018, CLIN INFECT DIS, V23, P1
   Biddle SJH, 2011, BRIT J SPORT MED, V45, P886, DOI 10.1136/bjsports-2011-090185
   Boone JE, 2007, INT J BEHAV NUTR PHY, V4, DOI 10.1186/1479-5868-4-26
   Bowling A, 2017, MENT HEALTH PHYS ACT, V12, P110, DOI 10.1016/j.mhpa.2017.03.005
   Burns RD, 2019, J PHYS ACT HEALTH, V16, P811, DOI 10.1123/jpah.2018-0549
   Cao H, 2011, PREV MED, V53, P316, DOI 10.1016/j.ypmed.2011.09.002
   Cao RL, 2020, J AFFECT DISORDERS, V274, P704, DOI 10.1016/j.jad.2020.05.064
   Carson V, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0220009
   Carson V, 2017, PREV MED, V95, P7, DOI 10.1016/j.ypmed.2016.12.005
   Carson V, 2016, J SCI MED SPORT, V19, P573, DOI 10.1016/j.jsams.2015.07.011
   Carson V, 2016, APPL PHYSIOL NUTR ME, V41, pS294, DOI 10.1139/apnm-2016-0026
   Carson V, 2015, INT J PUBLIC HEALTH, V60, P551, DOI 10.1007/s00038-015-0685-8
   Chaput JP, 2014, NUTR DIABETES, V4, DOI 10.1038/nutd.2014.14
   Chaput JP, 2013, APPL PHYSIOL NUTR ME, V38, P477, DOI 10.1139/apnm-2012-0382
   Chastin SFM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0139984
   Chen ST, 2021, J SPORT HEALTH SCI, V10, P349, DOI 10.1016/j.jshs.2020.07.002
   Chen Y., 2021, ADV SOCIAL SCI ED HU, V615, P1683
   Collings PJ, 2017, SPORTS MED, V47, P769, DOI 10.1007/s40279-016-0606-x
   Collins H, 2019, SPORTS MED-OPEN, V5, DOI 10.1186/s40798-019-0188-x
   Cristi-Montero C, 2019, J SPORT HEALTH SCI, V8, P55, DOI 10.1016/j.jshs.2018.03.004
   Crowe M, 2020, CAN J PUBLIC HEALTH, V111, P515, DOI 10.17269/s41997-020-00313-6
   Cureau FV, 2017, INT J OBESITY, V41, P551, DOI 10.1038/ijo.2016.210
   Dalene KE, 2017, OBES SCI PRACT, V3, P249, DOI 10.1002/osp4.114
   De Bourdeaudhuij I., 2012, J SCI MED SPORT, V15, pS41
   de Faria FR, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0234374
   de Greeff JW, 2018, J SCI MED SPORT, V21, P501, DOI 10.1016/j.jsams.2017.09.595
   del Pozo-Cruz B, 2019, INT J BEHAV NUTR PHY, V16, DOI 10.1186/s12966-019-0816-3
   del Pozo-Cruz B, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184472
   Department of Health and Aged Care Australian Government, 2019, PHYS ACTIVITY EXERCI
   Dewald JF, 2010, SLEEP MED REV, V14, P179, DOI 10.1016/j.smrv.2009.10.004
   Djalalinia S, 2017, J PEDIATR ENDOCR MET, V30, P731, DOI 10.1515/jpem-2016-0486
   Doherty C, 2014, SPORTS MED, V44, P123, DOI 10.1007/s40279-013-0102-5
   Dollman J., 2004, J SCI MED SPORT, V7, P85
   Dollman Jim, 2006, J Phys Act Health, V3, P191, DOI 10.1123/jpah.3.2.191
   Donnelly JE, 2016, MED SCI SPORT EXER, V48, P1197, DOI 10.1249/MSS.0000000000000901
   Dowd K, 2016, PEDIATR EXERC SCI, V28, P109, DOI 10.1123/pes.2015-0081
   Draper CE, 2020, J PHYS ACT HEALTH, V17, P109, DOI 10.1123/jpah.2019-0187
   Drenowatz C, 2014, EUR J SPORT SCI, V14, P100, DOI 10.1080/17461391.2012.732615
   Dumuid D, 2019, J PEDIATR-US, V208, P43, DOI 10.1016/j.jpeds.2018.12.030
   Dumuid D, 2018, STAT METHODS MED RES, V27, P3726, DOI 10.1177/0962280217710835
   Dumuid D, 2017, HEALTH EDUC BEHAV, V44, P918, DOI 10.1177/1090198117699508
   Eisenmann JC, 2008, INT J OBESITY, V32, P613, DOI 10.1038/sj.ijo.0803800
   Ekelund U, 2012, JAMA-J AM MED ASSOC, V307, P704, DOI 10.1001/jama.2012.156
   Fairclough Stuart J, 2018, Prev Med Rep, V11, P254, DOI 10.1016/j.pmedr.2018.07.011
   Fairclough SJ, 2017, INT J BEHAV NUTR PHY, V14, DOI 10.1186/s12966-017-0521-z
   de Moraes ACF, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0062006
   Fletcher EA, 2018, PUBLIC HEALTH NUTR, V21, P1115, DOI [10.1017/S136898001700372X, 10.1017/s136898001700372x]
   Gába A, 2020, BMC PEDIATR, V20, DOI 10.1186/s12887-020-02036-6
   García-Hermoso A, 2020, INT J CLIN HLTH PSYC, V20, P126, DOI 10.1016/j.ijchp.2020.03.001
   García-Hermoso A, 2017, OBES RES CLIN PRACT, V11, P44, DOI 10.1016/j.orcp.2015.07.006
   Gillis BT, 2019, SLEEP HEALTH, V5, P266, DOI 10.1016/j.sleh.2019.02.001
   Gleason MM, 2022, JAMA PEDIATR, V176, P532, DOI 10.1001/jamapediatrics.2022.0052
   Gordon-Larsen P, 2002, OBES RES, V10, P141, DOI 10.1038/oby.2002.23
   Guan HY, 2020, BMC PEDIATR, V20, DOI 10.1186/s12887-020-1969-6
   Guerrero MD, 2019, PEDIATRICS, V144, DOI 10.1542/peds.2019-0187
   Haapala EA, 2017, J SCI MED SPORT, V20, P583, DOI 10.1016/j.jsams.2016.11.003
   Hamer M, 2009, PEDIATRICS, V123, P1263, DOI 10.1542/peds.2008-1523
   Hansen BH, 2018, SPORTS MED, V48, P2401, DOI 10.1007/s40279-018-0909-1
   Hartwig TB, 2021, BRIT J SPORT MED, V55, P721, DOI 10.1136/bjsports-2020-102740
   Herman K., 2012, J SCI MED SPORT, V15, pS250
   Herman KM, 2015, J PHYS ACT HEALTH, V12, P20, DOI 10.1123/jpah.2013-0019
   Herman KM, 2014, PREV MED, V60, P115, DOI 10.1016/j.ypmed.2013.12.029
   Heshmat R, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0154502
   Higgins J, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.ED000049
   Hinde S, 2015, PHARMACOECONOMICS, V33, P5, DOI 10.1007/s40273-014-0205-3
   Hjorth MF, 2014, INT J OBESITY, V38, P959, DOI 10.1038/ijo.2013.229
   Hrafnkelsdottir SM, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0196286
   Huang WY, 2016, MED SCI SPORT EXER, V48, P2135, DOI 10.1249/MSS.0000000000001002
   Ishii K, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17030757
   Jakubec L, 2020, BMC PUBLIC HEALTH, V20, DOI 10.1186/s12889-020-09213-3
   Janssen I, 2017, APPL PHYSIOL NUTR ME, V42, P725, DOI 10.1139/apnm-2016-0681
   Janssen I, 2010, INT J BEHAV NUTR PHY, V7, DOI 10.1186/1479-5868-7-40
   Jones MA, 2020, J SPORT SCI, V38, P114, DOI 10.1080/02640414.2019.1685842
   Jones PR, 2019, ATHEROSCLEROSIS, V288, P186, DOI 10.1016/j.atherosclerosis.2019.05.023
   Kantomaa MT, 2016, J RES ADOLESCENCE, V26, P432, DOI 10.1111/jora.12203
   Katzmarzyk PT, 2015, MED SCI SPORT EXER, V47, P2062, DOI 10.1249/MSS.0000000000000649
   Keane E, 2017, PREV MED, V96, P21, DOI 10.1016/j.ypmed.2016.12.011
   Khan A, 2018, INT HEALTH, V10, P246, DOI 10.1093/inthealth/ihy019
   Kidokoro T, 2019, BMC PUBLIC HEALTH, V19, DOI 10.1186/s12889-019-8079-0
   Kieling C, 2010, AM J PSYCHIAT, V167, P14, DOI 10.1176/appi.ajp.2009.09060796
   Kim Y, 2016, J EPIDEMIOL, V26, P137, DOI 10.2188/jea.JE20150068
   Lacy KE, 2012, QUAL LIFE RES, V21, P1085, DOI 10.1007/s11136-011-0014-5
   Lane A, 2014, J PHYS ACT HEALTH, V11, P985, DOI 10.1123/jpah.2012-0182
   Laurson KR, 2008, J PEDIATR-US, V153, P209, DOI 10.1016/j.jpeds.2008.02.042
   Laurson Kelly R, 2014, ISRN Obes, V2014, P204540, DOI 10.1155/2014/204540
   Lee EY, 2018, MENT HEALTH PHYS ACT, V14, P66, DOI 10.1016/j.mhpa.2018.02.001
   Lee PH, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0092623
   Li SH, 2013, PLOS ONE, V8, DOI [10.1371/journal.pone.0067928, 10.1371/journal.pone.0083037, 10.1371/journal.pone.0053163, 10.1371/journal.pone.0057604]
   Lien A, 2020, PUBLIC HEALTH, V183, P8, DOI 10.1016/j.puhe.2020.03.011
   Liu ML, 2019, PSYCHOL RES BEHAV MA, V12, P1041, DOI 10.2147/PRBM.S220075
   Liu ML, 2016, BRIT J SPORT MED, V50, P1252, DOI 10.1136/bjsports-2015-095084
   López-Valenciano A, 2020, BRIT J SPORT MED, V54, P711, DOI 10.1136/bjsports-2018-099577
   Loprinzi PD, 2015, J DIABETES METAB DIS, V14, DOI 10.1186/s40200-015-0175-9
   Maher C, 2016, J SCI MED SPORT, V19, P1004, DOI 10.1016/j.jsams.2016.02.010
   Maher C, 2012, ACTA PAEDIATR, V101, P1170, DOI 10.1111/j.1651-2227.2012.02804.x
   Marques A, 2015, MED SCI SPORT EXER, V47, P575, DOI 10.1249/MSS.0000000000000426
   Martinez-Gomez D, 2011, ARCH DIS CHILD, V96, P240, DOI 10.1136/adc.2010.187161
   Matin N, 2017, INT HEALTH, V9, P58, DOI 10.1093/inthealth/ihw044
   Mavilidi MF, 2020, INT J EDUC RES, V102, DOI 10.1016/j.ijer.2020.101592
   Mavilidi MF, 2021, EDUC PSYCHOL REV, V33, P299, DOI 10.1007/s10648-020-09537-x
   Melkevik O., 2010, Norsk Epidemiologi, V20, P109
   Melkevik O, 2015, BMC PUBLIC HEALTH, V15, DOI 10.1186/s12889-015-1810-6
   Mielke GI, 2019, PREV MED, V119, P31, DOI 10.1016/j.ypmed.2018.12.008
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Monda KL, 2005, OBES RES, V13, P1042, DOI 10.1038/oby.2005.122
   Moore JB, 2013, J SPORT SCI, V31, P1520, DOI 10.1080/02640414.2013.793378
   da Silva ACM, 2019, EUR J CLIN NUTR, V73, P432, DOI 10.1038/s41430-018-0192-0
   Mota J, 2014, ANN HUM BIOL, V41, P506, DOI 10.3109/03014460.2014.909884
   Motamed-Gorji N, 2019, HEALTH QUAL LIFE OUT, V17, DOI 10.1186/s12955-018-1071-z
   Moura BP, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0225856
   Must A, 2005, INT J OBESITY, V29, pS84, DOI 10.1038/sj.ijo.0803064
   Nixon GM, 2008, SLEEP, V31, P71, DOI 10.1093/sleep/31.1.71
   Ogawa S, 2019, PSYCHIAT RES, V273, P456, DOI 10.1016/j.psychres.2018.12.085
   Omorou AY, 2016, QUAL LIFE RES, V25, P1169, DOI 10.1007/s11136-015-1172-7
   Parker KE, 2019, J SCI MED SPORT, V22, P319, DOI 10.1016/j.jsams.2018.08.015
   Patnode CD, 2011, J PHYS ACT HEALTH, V8, P457, DOI 10.1123/jpah.8.4.457
   Perez A, 2011, PREV CHRONIC DIS, V8
   Pérez-Rodrigo C, 2016, NUTRIENTS, V8, DOI 10.3390/nu8010011
   Pitanga Francisco JG, 2019, Rev. bras. cineantropom. desempenho hum., V21, pe58392, DOI 10.1590/1980-0037.2019v21e58392
   Porter AK, 2017, J PHYS ACT HEALTH, V14, P506, DOI 10.1123/jpah.2016-0165
   Rendo-Urteaga T, 2015, INT J CARDIOL, V186, P186, DOI 10.1016/j.ijcard.2015.03.176
   Roman-Viñas B, 2016, INT J BEHAV NUTR PHY, V13, DOI 10.1186/s12966-016-0449-8
   Sampasa-Kanyinga H, 2017, PUBLIC HEALTH, V153, P16, DOI 10.1016/j.puhe.2017.07.010
   Sampasa-Kanyinga H, 2020, J AFFECT DISORDERS, V274, P372, DOI 10.1016/j.jad.2020.05.096
   Sánchez-Oliva D, 2020, PSYCHOL SPORT EXERC, V47, DOI 10.1016/j.psychsport.2019.101558
   Sánchez-Oliva D, 2018, J PEDIATR-US, V203, P317, DOI 10.1016/j.jpeds.2018.07.092
   Santos DA, 2018, J SPORT SCI, V36, P1720, DOI 10.1080/02640414.2017.1411176
   Santos R, 2014, BRIT J SPORT MED, V48, P1508, DOI 10.1136/bjsports-2012-091610
   Sardinha LB, 2017, PEDIATR OBES, V12, P373, DOI 10.1111/ijpo.12153
   Saunders TJ, 2016, APPL PHYSIOL NUTR ME, V41, pS283, DOI 10.1139/apnm-2015-0626
   Shi Y, 2020, J PHYS ACT HEALTH, V17, P287, DOI 10.1123/jpah.2019-0230
   Sisson SB, 2010, J ADOLESCENT HEALTH, V47, P309, DOI 10.1016/j.jadohealth.2010.02.016
   Spengler S, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-1128
   Spruyt K, 2011, PEDIATRICS, V127, pE345, DOI 10.1542/peds.2010-0497
   Steele RM, 2009, AM J CLIN NUTR, V90, P1185, DOI 10.3945/ajcn.2009.28153
   Sun Y, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000021367
   Taheri E, 2019, J TROP PEDIATRICS, V65, P361, DOI 10.1093/tropej/fmy063
   Tahir MJ, 2019, AM J EPIDEMIOL, V188, P282, DOI 10.1093/aje/kwy236
   Talarico R, 2018, INT J OBESITY, V42, P1508, DOI 10.1038/s41366-018-0053-x
   Tanaka C, 2020, OBES RES CLIN PRACT, V14, P234, DOI 10.1016/j.orcp.2020.05.003
   Tanaka C, 2020, PEDIATR INT, V62, P1381, DOI 10.1111/ped.14322
   Tassitano RM, 2020, INT J PUBLIC HEALTH, V65, P881, DOI 10.1007/s00038-020-01418-y
   Taylor RW, 2020, INT J OBESITY, V44, P94, DOI 10.1038/s41366-019-0377-1
   te Velde SJ, 2007, BMC PUBLIC HEALTH, V7, DOI 10.1186/1471-2458-7-16
   Tremblay MS, 2020, J PHYS ACT HEALTH, V17, P92, DOI 10.1123/jpah.2019-0401
   Tremblay MS, 2016, APPL PHYSIOL NUTR ME, V41, pIII, DOI 10.1139/apnm-2016-0203
   Tremblay MS, 2011, INT J BEHAV NUTR PHY, V8, DOI 10.1186/1479-5868-8-98
   Trinh L, 2015, J CAN ACAD CHILD ADO, V24, P17
   Uddin R, 2020, ACTA PAEDIATR, V109, P1252, DOI 10.1111/apa.15079
   Väistö J, 2014, INT J BEHAV NUTR PHY, V11, DOI 10.1186/1479-5868-11-55
   Van den Bulck J, 2009, PREV MED, V48, P368, DOI 10.1016/j.ypmed.2009.02.006
   Verswijveren SJJM., 2020, J SPORT HEALTH SCI, V11, P234
   Vicente-Rodríguez G, 2009, BONE, V45, P925, DOI 10.1016/j.bone.2009.07.084
   von Elm E, 2007, PLOS MED, V4, P1623, DOI [10.1371/journal.pmed.0040296, 10.1371/journal.pmed.0040297, 10.1016/S0140-6736(07)61602-X]
   Walsh JJ, 2020, COMPUT HUM BEHAV, V108, DOI 10.1016/j.chb.2020.106312
   Walsh JJ, 2018, LANCET CHILD ADOLESC, V2, P783, DOI 10.1016/S2352-4642(18)30278-5
   Wang S, 2016, BMC MED GENET, V17, DOI 10.1186/s12881-016-0352-9
   Watson A, 2017, INT J BEHAV NUTR PHY, V14, DOI 10.1186/s12966-017-0569-9
   Weisser B, 2015, EUR HEART J, V36, P469
   Werneck AO, 2019, GEN HOSP PSYCHIAT, V59, P7, DOI 10.1016/j.genhosppsych.2019.04.010
   Wilkie HJ, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2015-010677
   Wilson R, 2020, SSM-POPUL HLTH, V10, DOI 10.1016/j.ssmph.2019.100535
   Wong M, 2017, PEDIATRICS, V140, DOI 10.1542/peds.2016-3656
   Wong SL, 2009, PREV CHRONIC DIS, V6
   Wu Y, 2020, MED SCI SPORT EXER, V52, P598, DOI 10.1249/MSS.0000000000002175
   Xi B, 2011, AM J EPIDEMIOL, V173, P1256, DOI 10.1093/aje/kwr008
   Zeng X, 2021, ACAD PEDIATR, V21, P63, DOI 10.1016/j.acap.2020.02.027
   Zhu XH, 2020, J PEDIATR-US, V218, P204, DOI 10.1016/j.jpeds.2019.11.031
   Zhu XH, 2019, MENT HEALTH PHYS ACT, V16, P60, DOI 10.1016/j.mhpa.2019.04.002
NR 176
TC 71
Z9 75
U1 22
U2 126
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD APR 6
PY 2023
VL 192
IS 4
BP 665
EP 679
DI 10.1093/aje/kwac212
EA DEC 2022
PG 15
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA C9LQ9
UT WOS:000931051900001
PM 36516992
OA hybrid, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Everding, B
   Hallam, JE
   Kohut, ML
   Lee, DC
   Anderson, AA
   Franke, WD
AF Everding, Braden
   Hallam, Justus E.
   Kohut, Marian L.
   Lee, Duck-chul
   Anderson, Amanda A.
   Franke, Warren D.
TI Association of Sleep Quality With Cardiovascular Disease Risk and Mental
   Health in Law Enforcement Officers
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
ID ISCHEMIC-HEART-DISEASE; METABOLIC SYNDROME; POLICE OFFICERS;
   INFLAMMATORY MARKERS; ATHEROSCLEROSIS; BIOMARKERS; POPULATION;
   PREDICTION; CHEMOKINES; DISORDERS
AB Objectives: The aim of the study was to determine whether sleep quality is associated with an increased risk for cardiovascular disease (CVD) or worsened mental health. Methods: Self-reported sleep quality, 35 inflammatory factors, CVD risk factors, personal stress, police operational and organizational stress, social support, depressive symptoms, and health-related quality of life were compared among a cohort of officers. Results: Of 379 officers, 39% and 27% had poor and borderline sleep quality. Sleep quality was not associated with either an altered inflammatory profile or worsened CVD risk factors. Compared with good sleepers, borderline and poor sleepers reported increased personal stress, police organizational and operational stress, and depressive symptoms, but decreased health-related quality of life. Conclusions: Poor sleep quality is prevalent in the law enforcement profession and is associated with worsened mental health but not with an increased risk for CVD.
C1 [Everding, Braden; Hallam, Justus E.; Kohut, Marian L.; Lee, Duck-chul; Anderson, Amanda A.; Franke, Warren D.] Iowa State Univ, Dept Kinesiol, 247 Forker Bldg, Ames, IA 50011 USA.
C3 Iowa State University
RP Franke, WD (corresponding author), Iowa State Univ, Dept Kinesiol, 247 Forker Bldg, Ames, IA 50011 USA.
EM wfranke@iastate.edu
CR Amendola KL, 2012, 237330 US DEP JUST N
   [Anonymous], 2000, MEAS HLTH DAYS, Patent No. 44
   Breland UM, 2008, ARTERIOSCL THROM VAS, V28, P1005, DOI 10.1161/ATVBAHA.108.162305
   Buysse DJ, 2014, SLEEP, V37, P9, DOI 10.5665/sleep.3298
   Buysse DJ, 2008, J CLIN SLEEP MED, V4, P563
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1016/0165-1781(89)90047-4
   Charles Luenda E, 2011, Int J Emerg Ment Health, V13, P229
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Cutrona CE., 1987, ADV PERSONAL RELATIO, V1, P37, DOI DOI 10.1017/CBO9781107415324.004
   D'Agostino RB, 2008, CIRCULATION, V117, P743, DOI 10.1161/CIRCULATIONAHA.107.699579
   DUBROW R, 1988, J OCCUP ENVIRON MED, V30, P650, DOI 10.1097/00043764-198808000-00011
   Franke WD, 2010, J OCCUP ENVIRON MED, V52, P561, DOI 10.1097/JOM.0b013e3181dd086b
   Franke WD, 1997, AM J IND MED, V31, P733
   Franke WD, 1998, J OCCUP ENVIRON MED, V40, P441, DOI 10.1097/00043764-199805000-00006
   Gerber M, 2013, J OCCUP HEALTH, V55, P376, DOI 10.1539/joh.13-0030-OA
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hartley Tara A, 2011, Int J Emerg Ment Health, V13, P211
   Hirshkowitz M, 2015, SLEEP HEALTH, V1, P40, DOI 10.1016/j.sleh.2014.12.010
   Hoevenaar-Blom MP, 2011, SLEEP, V34, P1487, DOI 10.5665/sleep.1382
   Irwin MR, 2008, BIOL PSYCHIAT, V64, P538, DOI 10.1016/j.biopsych.2008.05.004
   Luckhaupt SE, 2010, SLEEP, V33, P149, DOI 10.1093/sleep/33.2.149
   Lui MMS, 2012, J THORAC DIS, V4, P164, DOI 10.3978/j.issn.2072-1439.2012.01.06
   Martínez-Hervás S, 2014, CARDIOVASC RES, V103, P324, DOI 10.1093/cvr/cvu115
   McKnight-Eily L. R., 2011, Morbidity and Mortality Weekly Report, V60, P233
   Miller MA, 2011, J CLIN SLEEP MED, V7, pS31, DOI 10.5664/JCSM.1356
   Mullington JM, 2009, PROG CARDIOVASC DIS, V51, P294, DOI 10.1016/j.pcad.2008.10.003
   Nishiyama T, 2014, SLEEP MED, V15, P422, DOI 10.1016/j.sleep.2013.12.015
   Pai JK, 2004, NEW ENGL J MED, V351, P2599, DOI 10.1056/NEJMoa040967
   Pamukcu B, 2011, ANN MED, V43, P331, DOI 10.3109/07853890.2010.546362
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Rajaratnam SMW, 2011, JAMA-J AM MED ASSOC, V306, P2567, DOI 10.1001/jama.2011.1851
   Ramey SL, 2012, BIOL RES NURS, V14, P16, DOI 10.1177/1099800410396356
   Ridker PM, 2004, CIRCULATION, V109, P6, DOI 10.1161/01.CIR.0000133444.17867.56
   SARDINAS A, 1986, AM J PUBLIC HEALTH, V76, P1140, DOI 10.2105/AJPH.76.9.1140
   Slaven James E, 2011, Int J Emerg Ment Health, V13, P267
   Solarz David E, 2012, Front Biosci (Elite Ed), V4, P2490
   Subramanian M, 2015, CIRC RES, V116, pE13, DOI 10.1161/CIRCRESAHA.116.304794
   Thompson MM., 2006, Int J Stress Manag, V13, P494, DOI [DOI 10.1037/1072-5245.13.4.494, 10.1037/1072-5245.13.4.494]
   van Leeuwen WMA, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004589
   Violanti JM, 2014, DYING FOR THE JOB
   Violanti JM, 2009, ARCH ENVIRON OCCUP H, V64, P194, DOI 10.1080/19338240903241259
   Wang TJ, 2006, NEW ENGL J MED, V355, P2631, DOI 10.1056/NEJMoa055373
   White GE, 2012, ARTERIOSCL THROM VAS, V32, P589, DOI 10.1161/ATVBAHA.111.237412
   Wright BR, 2011, J OCCUP ENVIRON MED, V53, P730, DOI 10.1097/JOM.0b013e318220c2da
   Yoo H, 2013, J OCCUP ENVIRON MED, V55, P111, DOI 10.1097/JOM.0b013e31826e294c
   Zernecke A, 2010, CARDIOVASC RES, V86, P192, DOI 10.1093/cvr/cvp391
NR 46
TC 16
Z9 19
U1 2
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1076-2752
EI 1536-5948
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD AUG
PY 2016
VL 58
IS 8
BP E281
EP E286
DI 10.1097/JOM.0000000000000814
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA DT0DP
UT WOS:000381153200001
PM 27414012
DA 2025-06-11
ER

PT J
AU Root, AL
   Crossley, NP
   Heck, JL
   Mccage, S
   Proulx, J
   Jones, EJ
AF Root, Andrea L.
   Crossley, Nicole P.
   Heck, Jennifer L.
   Mccage, Shondra
   Proulx, Jeffrey
   Jones, Emily J.
TI Effects of Mindfulness-Based Interventions on Cardiometabolic-Related
   Adverse Pregnancy Outcomes
SO JOURNAL OF CARDIOVASCULAR NURSING
LA English
DT Article
DE cardiometabolic risk factors; cardiovascular pregnancy complications;
   mindfulness
ID CARDIOVASCULAR-DISEASE RISK; SCIENTIFIC STATEMENT; STRESS REDUCTION;
   PREVENTION; WOMEN; HEALTH; IMPACT
AB BackgroundGrowing evidence suggests maternal stress contributes to the development of adverse pregnancy outcomes that are associated with cardiovascular and cardiometabolic risk in birthing persons. Mindfulness-based interventions may positively affect psychological stress in pregnancy and, in turn, reduce stress. However, few study authors have examined the effects of mindfulness-based interventions on adverse pregnancy outcomes that heighten cardiovascular risk.ObjectiveThe aim of this study was to appraise available literature examining the effects of mindfulness-based interventions delivered during pregnancy on adverse pregnancy outcomes associated with future cardiovascular and cardiometabolic disease risk.MethodsIn this systematic review, multiple electronic databases were searched using major keywords, including "mindfulness-based intervention," "pregnancy," "preterm delivery," "gestational diabetes," "small for gestational age," "preeclampsia," and "hypertension in pregnancy" during February 2023.ResultsSix studies using mindfulness-based interventions during pregnancy were included. The review indicated that these interventions were largely effective at reducing prenatal stress; however, the overall effects of interventions were mixed concerning their impact on pregnancy complications. Study authors examining the effects on gestational diabetes-related outcomes reported significant improvements in blood glucose levels, hemoglobin A1c, and oral glucose tolerance. Outcomes were mixed or inconclusive related to the effects of interventions on the incidence of preterm birth, birth of a small-for-gestational-age newborn, and preeclampsia.ConclusionsMitigating cardiovascular and cardiometabolic risk-associated adverse pregnancy outcomes through mindfulness-based approaches may represent an emerging field of study. The few studies and limited, mixed findings synthesized in this review indicate that high-validity studies are warranted to examine the effects of mindfulness-based interventions on pregnancy complications that contribute to cardiovascular-related maternal morbidity and suboptimal life course health for diverse birthing persons.
C1 [Root, Andrea L.; Crossley, Nicole P.; Heck, Jennifer L.; Jones, Emily J.] Univ Oklahoma Hlth Sci Ctr, Fran & Earl Ziegler Coll Nursing, 1100 N Stonewall Ave, Oklahoma City, OK 73117 USA.
   [Mccage, Shondra] Univ Oklahoma Hlth Sci Ctr, Hudson Coll Publ Hlth, Oklahoma City, OK USA.
   [Proulx, Jeffrey] Brown Univ, Sch Publ Hlth, Fran & Earl Ziegler Coll Nursing, Providence, RI USA.
C3 University of Oklahoma System; University of Oklahoma Health Sciences
   Center; University of Oklahoma System; University of Oklahoma Health
   Sciences Center; Brown University
RP Root, AL (corresponding author), Univ Oklahoma Hlth Sci Ctr, Fran & Earl Ziegler Coll Nursing, 1100 N Stonewall Ave, Oklahoma City, OK 73117 USA.
EM ndrea-root@ouhsc.edu; Nicole-crossley@ouhsc.edu;
   Jennifer-heck@ouhsc.edu; shondra.mccage@chickasaw.net;
   Jeffrey_Proulx@brown.edu; Emily-j-jones@ouhsc.edu
OI Root, Andrea/0000-0002-4640-1075; Crossley, Nicole/0000-0003-2615-7463
CR Akselsson A, 2020, BJOG-INT J OBSTET GY, V127, P829, DOI 10.1111/1471-0528.16104
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alderdice F, 2012, J PSYCHOSOM OBST GYN, V33, P62, DOI 10.3109/0167482X.2012.673040
   American Psychological Association, Ethnicity and health in America: stress in the Native American community
   [Anonymous], 2013, PREGN MORT SURV SYST
   [Anonymous], Systematic Review and Literature Review Software by DistillerSR
   [Anonymous], 2022, Pregnancy-related deaths: data from Maternal Mortality Review Committees in 36 US states, 2017-2019
   Brown MC, 2013, EUR J EPIDEMIOL, V28, P1, DOI 10.1007/s10654-013-9762-6
   Bublitz MH, 2019, J ALTERN COMPLEM MED, V25, P444, DOI 10.1089/acm.2018.0331
   Caplan M, 2021, AM J PERINAT, V38, P1412, DOI 10.1055/s-0040-1713368
   Castro JP, 2003, CURR HYPERTENS REP, V5, P393, DOI 10.1007/s11906-003-0085-y
   Conversano C, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18062882
   Crovetto F, 2021, JAMA-J AM MED ASSOC, V326, P2150, DOI 10.1001/jama.2021.20178
   Dhillon A, 2017, MINDFULNESS, V8, P1421, DOI 10.1007/s12671-017-0726-x
   Downs SH, 1998, J EPIDEMIOL COMMUN H, V52, P377, DOI 10.1136/jech.52.6.377
   Epel E, 2019, INT J BEHAV MED, V26, P461, DOI 10.1007/s12529-019-09779-2
   Fisher V, 2023, APPL PSYCHOL-HLTH WE, V15, P1733, DOI 10.1111/aphw.12441
   Grundy SM, 2019, CIRCULATION, V139, pE1082, DOI 10.1161/CIR.0000000000000625
   Hermes W, 2012, OBSTET GYNECOL SURV, V67, P793, DOI 10.1097/OGX.0b013e31827682fc
   Higgins J, Cochrane Handbook for Systematic Reviews of Interventions Internet
   Hindiyeh NA, 2020, HEADACHE, V60, P1300, DOI 10.1111/head.13836
   Hobel CJ, 2008, CLIN OBSTET GYNECOL, V51, P333, DOI 10.1097/GRF.0b013e31816f2709
   Hooper P, 2008, CAN J OPHTHALMOL, V43, P180, DOI 10.3129/i08-001
   Hoyert D.L., 2019, Maternal mortality rates in the United States
   Kramer CK, 2019, DIABETOLOGIA, V62, P905, DOI 10.1007/s00125-019-4840-2
   Leng LL, 2023, COMPR PSYCHIAT, V122, DOI 10.1016/j.comppsych.2023.152375
   MacKinnon AL, 2021, MINDFULNESS, V12, P1173, DOI 10.1007/s12671-020-01585-2
   Marino F, 2021, BRAIN SCI, V11, DOI 10.3390/brainsci11060727
   Matvienko-Sikar K, 2016, PSYCHOL HEALTH, V31, P1415, DOI 10.1080/08870446.2016.1220557
   Mehta LS, 2023, CIRCULATION, V147, P1471, DOI 10.1161/CIR.0000000000001139
   Mehta LS, 2020, CIRCULATION, V141, pE884, DOI 10.1161/CIR.0000000000000772
   Meibert P, 2011, PSYCHOTHER PSYCH MED, V61, P328, DOI 10.1055/s-0031-1276859
   Monk C, 2020, ARCH WOMEN MENT HLTH, V23, P361, DOI 10.1007/s00737-019-00970-8
   Mosca L, 2011, J AM COLL CARDIOL, V57, P1404, DOI [10.1016/j.jacc.2011.02.005, 10.1161/CIR.0b013e31820faaf8]
   National Center for Complementary and Integrative Health, Whole person health: what it is and why it's important
   Ngan HY, 2021, DIABETIC MED, V38, DOI 10.1111/dme.14525
   Ni YX, 2020, J NURS SCHOLARSHIP, V52, P379, DOI 10.1111/jnu.12560
   Okoth K, 2020, BMJ-BRIT MED J, V371, DOI 10.1136/bmj.m3502
   OuYang H, 2021, J DIABETES RES, V2021, DOI 10.1155/2021/9959779
   Page MJ, 2021, BMJ-BRIT MED J, V372, DOI [10.1136/bmj.n71, 10.1136/bmj.n160]
   Parikh NI, 2021, CIRCULATION, V143, pE902, DOI 10.1161/CIR.0000000000000961
   Petersen EE, 2019, MMWR-MORBID MORTAL W, V68, P762, DOI 10.15585/mmwr.mm6835a3
   Puertas-Gonzalez JA, 2023, CURR PSYCHOL, V42, P22013, DOI 10.1007/s12144-022-03305-6
   Rich-Edwards JW, 2014, EPIDEMIOL REV, V36, P57, DOI 10.1093/epirev/mxt006
   Rich-Edwards JW, 2009, WOMENS HEALTH, V5, P101, DOI 10.2217/17455057.5.2.101
   Scott-Sheldon LAJ, 2020, ANN BEHAV MED, V54, P67, DOI 10.1093/abm/kaz020
   Segal Z.V., 2004, Mindfulness and acceptance: Expanding the cognitivebehavioral tradition, P45, DOI DOI 10.1017/CBO9780511521263.015
   Shi ZR, 2017, MINDFULNESS, V8, P823, DOI 10.1007/s12671-016-0673-y
   Skewes MC, 2019, AM PSYCHOL, V74, P88, DOI 10.1037/amp0000331
   Staneva A, 2015, WOMEN BIRTH, V28, P179, DOI 10.1016/j.wombi.2015.02.003
   Taylor BL, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0155720
   Teasdale JD, 2000, J CONSULT CLIN PSYCH, V68, P615, DOI 10.1037//0022-006X.68.4.615
   Thong EP, 2022, J CARDIOVASC DEV DIS, V9, DOI 10.3390/jcdd9020055
   Vounzoulaki E, 2020, BMJ-BRIT MED J, V369, DOI 10.1136/bmj.m1361
   West S, 2002, Evid Rep Technol Assess (Summ), P1
   Williams CA, 2020, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD013400.pub2
   Youngwanichsetha S, 2014, APPL NURS RES, V27, P227, DOI 10.1016/j.apnr.2014.02.002
   Zeng ZD, 2017, ANN NUTR METAB, V70, P59, DOI 10.1159/000459633
   Zhang SC, 2013, OBSTET GYNECOL SURV, V68, P825, DOI 10.1097/OGX.0000000000000001
NR 59
TC 1
Z9 1
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0889-4655
EI 1550-5049
J9 J CARDIOVASC NURS
JI J. Cardiovasc. Nurs.
PD JUL-AUG
PY 2024
VL 39
IS 4
BP 335
EP 346
DI 10.1097/JCN.0000000000001054
PG 12
WC Cardiac & Cardiovascular Systems; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Nursing
GA TM2P5
UT WOS:001241616700004
PM 37878581
OA Bronze
DA 2025-06-11
ER

PT J
AU Scott, EM
   Carpenter, JS
   Iorfino, F
   Cross, SPM
   Hermens, DF
   Gehue, J
   Wilson, C
   White, D
   Naismith, SL
   Guastella, AJ
   Hickie, IB
AF Scott, Elizabeth M.
   Carpenter, Joanne S.
   Iorfino, Frank
   Cross, Shane P. M.
   Hermens, Daniel F.
   Gehue, Jeanne
   Wilson, Chloe
   White, Django
   Naismith, Sharon L.
   Guastella, Adam J.
   Hickie, Ian B.
TI What is the prevalence, and what are the clinical correlates, of insulin
   resistance in young people presenting for mental health care? A
   cross-sectional study
SO BMJ OPEN
LA English
DT Article
ID MAJOR DEPRESSIVE DISORDER; HOMEOSTASIS MODEL ASSESSMENT; PSYCHOSOCIAL
   RISK-FACTORS; BETA-CELL FUNCTION; METABOLIC SYNDROME; PHYSICAL-ACTIVITY;
   BIPOLAR DISORDER; CARDIOMETABOLIC RISK; 2ND-GENERATION ANTIPSYCHOTICS;
   PSYCHOTIC DISORDERS
AB Objectives To report the distribution and predictors of insulin resistance (IR) in young people presenting to primary care-based mental health services.
   Design Cross-sectional.
   Setting Headspace-linked clinics operated by the Brain and Mind Centre of the University of Sydney.
   Participants 768 young people (66% female, mean age 19.7 +/- 3.5, range 12-30 years).
   Main outcome measures IR was estimated using the updated homeostatic model assessment (HOMA2-IR). Height and weight were collected from direct measurement or self-report for body mass index (BMI).
   Results For BMI, 20.6% of the cohort were overweight and 10.2% were obese. However, <1% had an abnormally high fasting blood glucose (>6.9 mmol/L). By contrast, 9.9% had a HOMA2-IR score >2.0 (suggesting development of IR) and 11.7% (n=90) had a score between 1.5 and 2. Further, there was a positive correlation between BMI and HOMA2-IR (r=0.44, p<0.001). Participants in the upper third of HOMA2-IR scores are characterised by younger age, higher BMIs and depression as a primary diagnosis. HOMA2-IR was predicted by younger age (beta=0.19, p<0.001) and higher BMI (beta=0.49, p<0.001), together explaining 22% of the variance (F-(2,F-361)=52.1, p<0.001).
   Conclusions Emerging IR is evident in a significant subgroup of young people presenting to primary care-based mental health services. While the major modifiable risk factor is BMI, a large proportion of the variance is not accounted for by other demographic, clinical or treatment factors. Given the early emergence of IR, secondary prevention interventions may need to commence prior to the development of full-threshold or major mood or psychotic disorders.
C1 [Scott, Elizabeth M.; Carpenter, Joanne S.; Iorfino, Frank; Cross, Shane P. M.; Hermens, Daniel F.; Gehue, Jeanne; Wilson, Chloe; White, Django; Naismith, Sharon L.; Guastella, Adam J.; Hickie, Ian B.] Univ Sydney, Brain & Mind Ctr, Sydney, NSW, Australia.
   [Scott, Elizabeth M.] Univ Notre Dame, Sch Med, Sydney, NSW, Australia.
   [Hermens, Daniel F.] Sunshine Coast Mind & Neurosci Thompson Inst, Birtinya, Qld, Australia.
C3 University of Sydney; The University of Notre Dame Australia
RP Hickie, IB (corresponding author), Univ Sydney, Brain & Mind Ctr, Sydney, NSW, Australia.
EM ian.hickie@sydney.edu.au
RI Guastella, Adam/JCE-9327-2023; Iorfino, Frank/AAD-8492-2021; Carpenter,
   Joanne/HZK-3629-2023; Hickie, Ian/K-8975-2015
OI Naismith, Sharon/0000-0001-9076-2778; Carpenter,
   Joanne/0000-0002-9766-6700; Scott, Elizabeth/0000-0003-3907-0324; Cross,
   Shane/0000-0002-5413-8342; Hermens, Daniel/0000-0002-8570-2663; Iorfino,
   Frank/0000-0003-1109-0972; Hickie, Ian/0000-0001-8832-9895; Guastella,
   Adam/0000-0001-8178-4625
FU National Health and Medical Research Council (NHMRC) including Centre of
   Research Excellence [1061043]; National Health and Medical Research
   Council (NHMRC) including Australia Fellowship [511921]; National Health
   and Medical Research Council (NHMRC) including Clinical Research
   Fellowship [402864]
FX This work was partially supported by grants from the National Health and
   Medical Research Council (NHMRC) including Centre of Research Excellence
   (No. 1061043), Australia Fellowship (No. 511921 awarded to IBH) and
   Clinical Research Fellowship (No. 402864 awarded to SLN).
CR Abdul-Ghani MA, 2006, DIABETES CARE, V29, P1130, DOI 10.2337/dc05-2179
   Amare AT, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/tp.2016.261
   Andrade Maria Izabel Siqueira de, 2016, Rev. paul. pediatr., V34, P234, DOI 10.1016/j.rpped.2015.08.006
   [Anonymous], 2016, Equally Well Consensus Statement: Improving the physical health and wellbeing of people living with mental illness in Australia
   Ata N, 2018, BMC PEDIATR, V18, DOI 10.1186/s12887-018-1289-2
   Barandas R, 2015, CURR PSYCHIAT REP, V17, DOI 10.1007/s11920-015-0637-2
   Bunker SJ, 2003, MED J AUSTRALIA, V178, P272, DOI 10.5694/j.1326-5377.2003.tb05193.x
   Cadenas-Sanchez C, 2017, J ADOLESCENT HEALTH, V61, P107, DOI 10.1016/j.jadohealth.2017.01.018
   Colquhoun DM, 2013, MED J AUSTRALIA, V198, P483, DOI 10.5694/mja13.10153
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   Correll CU, 2015, WORLD PSYCHIATRY, V14, P119, DOI 10.1002/wps.20204
   Correll CU, 2009, JAMA-J AM MED ASSOC, V302, P1765, DOI 10.1001/jama.2009.1549
   De Hert M, 2011, EUR PSYCHIAT, V26, P144, DOI 10.1016/j.eurpsy.2010.09.011
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P138
   Fleischman A, 2012, PUBLIC HEALTH REV, V34, DOI 10.1007/BF03391679
   Galletly CA, 2012, AUST NZ J PSYCHIAT, V46, P753, DOI 10.1177/0004867412453089
   Gayoso-Diz P, 2013, BMC ENDOCR DISORD, V13, DOI 10.1186/1472-6823-13-47
   Ghasemi A, 2015, ACTA DIABETOL, V52, P905, DOI 10.1007/s00592-015-0730-3
   Glozier N, 2013, MED J AUSTRALIA, V199, P179, DOI 10.5694/mja13.10440
   Harvey PD, 2018, AM J PSYCHIAT, V175, P1054, DOI 10.1176/appi.ajp.2018.18060730
   Henderson DC, 2015, LANCET PSYCHIAT, V2, P452, DOI 10.1016/S2215-0366(15)00115-7
   Hickie IB, 2011, EARLY INTERV PSYCHIA, V5, P63, DOI 10.1111/j.1751-7893.2010.00243.x
   Hill NR, 2013, DIABETES CARE, V36, P2324, DOI 10.2337/dc12-0607
   Hinnouho GM, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0174678
   Hirsch L, 2017, DRUG SAFETY, V40, P771, DOI 10.1007/s40264-017-0543-0
   Hoogendoorn CJ, 2017, CURR DIABETES REP, V17, DOI 10.1007/s11892-017-0923-y
   Jeffery AN, 2012, DIABETES CARE, P41
   John AP, 2009, MED J AUSTRALIA, V190, P176, DOI 10.5694/j.1326-5377.2009.tb02342.x
   Joseph JJ, 2017, ANN NY ACAD SCI, V1391, P20, DOI 10.1111/nyas.13217
   Kilbourne AM, 2009, GEN HOSP PSYCHIAT, V31, P555, DOI 10.1016/j.genhosppsych.2009.07.008
   Lamers F, 2018, PSYCHOL MED, V48, P1102, DOI 10.1017/S0033291717002483
   Lamers F, 2013, MOL PSYCHIATR, V18, P692, DOI 10.1038/mp.2012.144
   Lawrence David, 2013, BMJ, V346, pf2539, DOI 10.1136/bmj.f2539
   Lima LMTR, 2017, AN ACAD BRAS CIENC, V89, P591, DOI 10.1590/0001-3765201720160394
   Mangurian C, 2016, J GEN INTERN MED, V31, P1083, DOI 10.1007/s11606-016-3712-4
   Matta J, 2019, J AFFECT DISORDERS, V244, P25, DOI 10.1016/j.jad.2018.09.072
   McGorry Patrick, 2013, Br J Psychiatry Suppl, V54, ps30, DOI 10.1192/bjp.bp.112.119214
   McGorry PD, 2007, MED J AUSTRALIA, V187, pS68
   Medici Valentina, 2016, Curr Gastroenterol Rep, V18, P2, DOI 10.1007/s11894-015-0479-4
   Moon S, 2018, J KOREAN MED SCI, V33, DOI 10.3346/jkms.2018.33.e197
   Moran A, 1999, DIABETES, V48, P2039, DOI 10.2337/diabetes.48.10.2039
   Motamed N, 2016, J DIABETES COMPLICAT, V30, P269, DOI 10.1016/j.jdiacomp.2015.11.019
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Murguia-Romero M, 2014, INTERN MED OPEN ACCE, DOI [10.4172/2165-8048.S6-001, DOI 10.4172/2165-8048.S6-001]
   Nordentoft M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055176
   Pyykkönen AJ, 2011, DIABETES CARE, V34, P2545, DOI 10.2337/dc11-0107
   Rojo LE, 2015, PHARMACOL RES, V101, P74, DOI 10.1016/j.phrs.2015.07.022
   Salvi V, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0182088
   Sarwar N, 2010, LANCET, V375, P2215, DOI 10.1016/s0140-6736(10)60484-9
   Scott EM, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2014-007066
   Scott EM, 2012, MED J AUSTRALIA, V196, P136, DOI 10.5694/mja11.10481
   Shashaj B, 2016, ACTA DIABETOL, V53, P251, DOI 10.1007/s00592-015-0782-4
   Sjo CP, 2017, J CHILD ADOL PSYCHOP, V27, P884, DOI 10.1089/cap.2016.0171
   Vancampfort D, 2017, WORLD PSYCHIATRY, V16, P308, DOI 10.1002/wps.20458
   Vancampfort D, 2016, J AFFECT DISORDERS, V201, P145, DOI 10.1016/j.jad.2016.05.020
   Vancampfort D, 2016, WORLD PSYCHIATRY, V15, P166, DOI 10.1002/wps.20309
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Viron MJ, 2010, PSYCHOSOMATICS, V51, P458, DOI 10.1176/appi.psy.51.6.458
   Vukovic R, 2015, EUR J PEDIATR, V174, P1649, DOI 10.1007/s00431-015-2587-4
   Yankey BNA, 2016, DIABETES METAB SYND, V10, pS89, DOI 10.1016/j.dsx.2016.03.001
NR 60
TC 15
Z9 16
U1 0
U2 1
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD MAY
PY 2019
VL 9
IS 5
AR e025674
DI 10.1136/bmjopen-2018-025674
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA IC7YG
UT WOS:000471192800136
PM 31138580
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pervanidou, P
   Chrousos, GP
AF Pervanidou, Panagiota
   Chrousos, George P.
TI Metabolic consequences of stress during childhood and adolescence
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Review
ID PITUITARY-ADRENAL AXIS; SHORT-SLEEP DURATION; MOTOR-VEHICLE ACCIDENTS;
   HYPOTHALAMIC AMENORRHEA; CORTISOL CONCENTRATIONS; EMOTIONAL-STRESS;
   HUMAN PHYSIOLOGY; TELOMERE LENGTH; DEPRESSION; LEPTIN
AB Stress, that is, the state of threatened or perceived as threatened homeostasis, is associated with activation of the stress system, mainly comprised by the hypothalamic-pituitary-adrenal axis and the arousal/sympathetic nervous systems. The stress system normally functions in a circadian manner and interacts with other systems to regulate a variety of behavioral, endocrine, metabolic, immune, and cardiovascular functions. However, the experience of acute intense physical or emotional stress, as well as of chronic stress, may lead to the development of or may exacerbate several psychologic and somatic conditions, including anxiety disorders, depression, obesity, and the metabolic syndrome. In chronically stressed individuals, both behavioral and neuroendocrine mechanisms promote obesity and metabolic abnormalities: unhealthy lifestyles in conjunction with dysregulation of the stress system and increased secretion of cortisol, catecholamines, and interleukin-6, with concurrently elevated insulin concentrations, lead to development of central obesity, insulin resistance, and the metabolic syndrome. Fetal life, childhood, and adolescence are particularly vulnerable periods of life to the effects of intense acute or chronic stress. Similarly, these life stages are crucial for the later development of behavioral, metabolic, and immune abnormalities. Developing brain structures and functions related to stress regulation, such as the amygdala, the hippocampus, and the mesocorticolimbic system, are more vulnerable to the effects of stress compared with mature structures in adults. Moreover, chronic alterations in cortisol secretion in children may affect the timing of puberty, final stature, and body composition, as well as cause early-onset obesity, metabolic syndrome, and type 2 diabetes mellitus. The understanding of stress mechanisms leading to metabolic abnormalities in early life may lead to more effective prevention and intervention strategies of obesity-related health problems. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Pervanidou, Panagiota; Chrousos, George P.] Univ Athens, Sch Med, Dept Pediat 1, Aghia Sophia Childrens Hosp, GR-11527 Athens, Greece.
C3 Athens Medical School; National & Kapodistrian University of Athens; The
   Aghia Sophia Children's Hospital
RP Pervanidou, P (corresponding author), Univ Athens, Sch Med, Dept Pediat 1, Aghia Sophia Childrens Hosp, GR-11527 Athens, Greece.
EM ppervanid@med.uoa.gr
RI Chrousos, George/G-8702-2011; Pervanidou, Panagiota/ABI-6356-2020
OI Pervanidou, Panagiota/0000-0002-6593-6489
CR Ahima RS, 2006, PROG BRAIN RES, V153, P155, DOI 10.1016/S0079-6123(06)53009-2
   Al-Attas OS, 2010, EUR J ENDOCRINOL, V163, P601, DOI 10.1530/EJE-10-0241
   Al-Daghri NM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0018182
   Al-Disi D, 2010, ENDOCR J, V57, P915, DOI 10.1507/endocrj.K10E-145
   [Anonymous], METABOLISM IN PRESS, DOI DOI 10.1111/j.1365-2869.2010.00844.x
   [Anonymous], EXTREME FEAR SHYNESS
   Arita Y, 1999, BIOCHEM BIOPH RES CO, V257, P79, DOI 10.1006/bbrc.1999.0255
   Askari H, 2005, METABOLISM, V54, P876, DOI 10.1016/j.metabol.2005.01.035
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   Brown LC, 2005, DIABETES CARE, V28, P1063, DOI 10.2337/diacare.28.5.1063
   Chan JL, 2005, LANCET, V366, P74, DOI 10.1016/S0140-6736(05)66830-4
   Charmandari E, 2003, HORM RES, V59, P161, DOI 10.1159/000069325
   Charmandari E, 2005, ANNU REV PHYSIOL, V67, P259, DOI 10.1146/annurev.physiol.67.040403.120816
   Charmandari E, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025612
   Chou SH, 2011, P NATL ACAD SCI USA, V108, P6585, DOI 10.1073/pnas.1015674108
   Chrousos G P., 2001, Endocrinology Metabolism, P609, DOI DOI 10.1016/j.cell.2006.03.033
   Chrousos GP, 2009, NAT REV ENDOCRINOL, V5, P374, DOI 10.1038/nrendo.2009.106
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   Chrousos GP, 1998, J CLIN ENDOCR METAB, V83, P1842, DOI 10.1210/jc.83.6.1842
   CHROUSOS GP, 1995, NEW ENGL J MED, V332, P1351, DOI 10.1056/NEJM199505183322008
   Chrousos GP, 1998, ANN NY ACAD SCI, V851, P311, DOI 10.1111/j.1749-6632.1998.tb09006.x
   CHROUSOS GP, 1992, JAMA-J AM MED ASSOC, V267, P1244, DOI 10.1001/jama.267.9.1244
   DALLMAN MF, 1993, FRONT NEUROENDOCRIN, V14, P303, DOI 10.1006/frne.1993.1010
   Dardeno TA, 2010, FRONT NEUROENDOCRIN, V31, P377, DOI 10.1016/j.yfrne.2010.06.002
   DEBELLIS MD, 1994, J CLIN ENDOCR METAB, V78, P249, DOI 10.1210/jc.78.2.249
   DEBELLIS MD, 1994, J AM ACAD CHILD PSY, V33, P320, DOI 10.1097/00004583-199403000-00004
   DINNEEN S, 1993, J CLIN INVEST, V92, P2283, DOI 10.1172/JCI116832
   Dunlop S A, 1997, J Matern Fetal Med, V6, P309
   EDWARDS E, 1990, NEUROPSYCHOPHARMACOL, V3, P109
   Eleftheriades M, 2007, Encyclopedia of Stress, P46, DOI [10.1016/B978-012373947-6.00492-X, DOI 10.1016/B978-012373947-6.00492-X, DOI 10.1016/B978-012373947-6/00492-X]
   Eleftheriades M, 2006, ANN NY ACAD SCI, V1092, P319, DOI 10.1196/annals.1365.047
   Entringer S, 2011, P NATL ACAD SCI USA, V108, pE513, DOI 10.1073/pnas.1107759108
   Figlewicz DP, 2003, AM J PHYSIOL-REG I, V284, pR882, DOI 10.1152/ajpregu.00602.2002
   Fram RY, 2010, J BURN CARE RES, V31, P728, DOI 10.1097/BCR.0b013e3181eebe63
   Gangwisch JE, 2007, SLEEP, V30, P1667, DOI 10.1093/sleep/30.12.1667
   Gauglitz GG, 2009, J CLIN ENDOCR METAB, V94, P1656, DOI 10.1210/jc.2008-1947
   Gluckman PD, 2005, TRENDS ECOL EVOL, V20, P527, DOI 10.1016/j.tree.2005.08.001
   Gold PW, 2002, MOL PSYCHIATR, V7, P254, DOI 10.1038/sj.mp.4001032
   Goossens L, 2009, EUR EAT DISORD REV, V17, P68, DOI 10.1002/erv.892
   Gordon CM, 2010, NEW ENGL J MED, V363, P365, DOI 10.1056/NEJMcp0912024
   Hales CN, 2001, BRIT MED BULL, V60, P5, DOI 10.1093/bmb/60.1.5
   Herndon DN, 2004, LANCET, V363, P1895, DOI 10.1016/S0140-6736(04)16360-5
   Kajantie E, 2010, NEUROSCI BIOBEHAV R, V35, P23, DOI 10.1016/j.neubiorev.2009.11.013
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Kim SM, 2011, METABOLISM, V60, P1294, DOI 10.1016/j.metabol.2011.01.013
   Kino T., 2005, TEC BEHAV N 1, P295, DOI 10.1016/S0921-0709(05)80017-3
   Kino T, 2011, ENDOCR DEV, V20, P116, DOI 10.1159/000321232
   Koupil I, 2007, EUR J EPIDEMIOL, V22, P223, DOI 10.1007/s10654-007-9113-6
   Kynde I, 2009, METABOLISM, V58, P1817, DOI 10.1016/j.metabol.2009.06.014
   Lauder J.M., 1988, Progress in Brain Research, V73, P365, DOI DOI 10.1096/fj.08-117697
   Lawson EA, 2011, EUR J ENDOCRINOL, V164, P253, DOI 10.1530/EJE-10-0523
   Lawson EA, 2009, J CLIN ENDOCR METAB, V94, P4710, DOI 10.1210/jc.2009-1046
   Licinio J, 1997, NAT MED, V3, P575, DOI 10.1038/nm0597-575
   Mantzoros CS, 2011, AM J PHYSIOL-ENDOC M, V301, pE567, DOI 10.1152/ajpendo.00315.2011
   McEwen BS, 2008, METABOLISM, V57, pS11, DOI 10.1016/j.metabol.2008.07.006
   Meyer SE, 2001, DEV PSYCHOPATHOL, V13, P565, DOI 10.1017/S095457940100308X
   Misra M, 2011, NEUROENDOCRINOLOGY, V93, P65, DOI 10.1159/000323771
   Misra M, 2010, ENDOCR DEV, V17, P197, DOI 10.1159/000262540
   Muhlhausler B, 2009, TRENDS ENDOCRIN MET, V20, P51, DOI 10.1016/j.tem.2008.10.006
   Mullington JM, 2003, J NEUROENDOCRINOL, V15, P851, DOI 10.1046/j.1365-2826.2003.01069.x
   Nader N, 2010, TRENDS ENDOCRIN MET, V21, P277, DOI 10.1016/j.tem.2009.12.011
   Nader N, 2009, FASEB J, V23, P1572, DOI 10.1096/fj.08-117697
   Noll JG, 2007, PEDIATRICS, V120, pE61, DOI 10.1542/peds.2006-3058
   Pejovic S, 2010, J SLEEP RES, V19, P552, DOI 10.1111/j.1365-2869.2010.00844.x
   Pervanidou P, 2008, J NEUROENDOCRINOL, V20, P632, DOI 10.1111/j.1365-2826.2008.01701.x
   Pervanidou P, 2007, HORM METAB RES, V39, P413, DOI 10.1055/s-2007-981461
   Pervanidou P, 2008, STRESS, V11, P438, DOI 10.1080/10253890801890622
   Pervanidou P., 2011, Eur. Health Psychol, V13, P48, DOI DOI 10.1016/j.psyneuen.2006.11.009
   Pervanidou P, 2007, PSYCHONEUROENDOCRINO, V32, P991, DOI 10.1016/j.psyneuen.2007.07.001
   Pervanidou P, 2007, BIOL PSYCHIAT, V62, P1095, DOI 10.1016/j.biopsych.2007.02.008
   Pervanidou P, 2011, INT J PEDIATR OBES, V6, P21, DOI 10.3109/17477166.2011.615996
   Pervanidou P, 2009, PSYCHIAT THEOR APPL, P157
   Pervanidou P, 2010, PROG BRAIN RES, V182, P149, DOI 10.1016/S0079-6123(10)82005-9
   Rosmond R, 1998, J CLIN ENDOCR METAB, V83, P1853, DOI 10.1210/jc.83.6.1853
   SAPOLSKY RM, 1990, J NEUROSCI, V10, P2897, DOI 10.1523/jneurosci.10-09-02897.1990
   Scheer FAJL, 2010, DIABETOLOGIA, V53, P2401, DOI 10.1007/s00125-010-1869-7
   Scheer FAJL, 2010, P NATL ACAD SCI USA, V107, P20541, DOI 10.1073/pnas.1006749107
   Scheer FAJL, 2009, P NATL ACAD SCI USA, V106, P4453, DOI 10.1073/pnas.0808180106
   Schneider LF, 2008, FERTIL STERIL, V90, P121, DOI 10.1016/j.fertnstert.2007.06.002
   Schneider M, 2007, OBESITY, V15, P2328, DOI 10.1038/oby.2007.276
   Seegers V, 2011, AM J EPIDEMIOL, V173, P621, DOI 10.1093/aje/kwq389
   Shea SA, 2005, J CLIN ENDOCR METAB, V90, P2537, DOI 10.1210/jc.2004-2232
   Sienkiewicz E, 2011, METABOLISM, V60, P1211, DOI 10.1016/j.metabol.2011.05.016
   Spruyt K, 2011, PEDIATRICS, V127, pE345, DOI 10.1542/peds.2010-0497
   STEPHENS TW, 1995, NATURE, V377, P530, DOI 10.1038/377530a0
   Teicher MH, 2002, PSYCHIAT CLIN N AM, V25, P397, DOI 10.1016/S0193-953X(01)00003-X
   Trickett PK, 2010, DEV PSYCHOPATHOL, V22, P165, DOI 10.1017/S0954579409990332
   Verhoeven JJ, 2011, CRIT CARE, V15, DOI 10.1186/cc10006
   Vgontzas AN, 2008, INT J OBESITY, V32, P801, DOI 10.1038/ijo.2008.4
   Vgontzas AN, 2009, SLEEP, V32, P491, DOI 10.1093/sleep/32.4.491
   Vogelzangs N, 2007, PSYCHONEUROENDOCRINO, V32, P151, DOI 10.1016/j.psyneuen.2006.11.009
   Warren MP, 2001, ENDOCRIN METAB CLIN, V30, P611, DOI 10.1016/S0889-8529(05)70204-8
   Whooley MA, 2006, JAMA-J AM MED ASSOC, V295, P2874, DOI 10.1001/jama.295.24.2874
NR 93
TC 245
Z9 277
U1 1
U2 82
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD MAY
PY 2012
VL 61
IS 5
BP 611
EP 619
DI 10.1016/j.metabol.2011.10.005
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 936VH
UT WOS:000303617600002
PM 22146091
DA 2025-06-11
ER

PT J
AU Clausing, ES
   Non, AL
AF Clausing, Elizabeth S.
   Non, Amy L.
TI Epigenetics as a Mechanism of Developmental Embodiment of Stress,
   Resilience, and Cardiometabolic Risk Across Generations of Latinx
   Immigrant Families
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE epigenetic; embodiment; stress; resilience (psychological); Latinx;
   maternal and child health; cardiometabolic health
ID DNA METHYLATION; SOCIOECONOMIC-STATUS; WAIST CIRCUMFERENCE;
   UNITED-STATES; EVERYDAY DISCRIMINATION; ACCULTURATIVE STRESS;
   AFRICAN-AMERICAN; MATERNAL STRESS; HEALTH; DEPRESSION
AB Psychosocial stressors can become embodied to alter biology throughout the life course in ways that may have lasting health consequences. Immigrants are particularly vulnerable to high burdens of stress, which have heightened in the current sociopolitical climate. This study is an investigation of how immigration-related stress (IRS) may impact the cardiometabolic risk and epigenetic markers of Latinx immigrant mothers and children in Nashville, TN. We compared stress and resilience factors reported by Latina immigrant mothers and their children (aged 5-13) from two time points spanning the 2016 U.S. presidential election (June 2015-June 2016 baseline, n = 81; March-September 2018 follow-up, n = 39) with cardiometabolic risk markers (BMI, waist circumference, and blood pressure). We also analyzed these factors in relation to DNA methylation in saliva of stress-related candidate genes (SLC6A4 and FKBP5), generated via bisulfite pyrosequencing (complete case n's range from 67-72 baseline and 29-31 follow-up) (n's range from 80 baseline to 36 follow-up). We found various associations with cardiometabolic risk, such as higher social support and greater acculturation were associated with lower BMI in mothers; discrimination and school stress associated with greater waist circumferences in children. Very few exposures associated with FKBP5, but various stressors associated with methylation at many sites in SLC6A4, including immigrant-related stress in both mothers and children, and fear of parent deportation in children. Additionally, in the mothers, total maternal stress, health stress, and subjective social status associated with methylation at multiple sites of SLC6A4. Acculturation associated with methylation in mothers in both genes, though directions of effect varied over time. We also find DNA methylation at SLC6A4 associates with measures of adiposity and blood pressure, suggesting that methylation may be on the pathway linking stress with cardiometabolic risk. More research is needed to determine the role of these epigenetic differences in contributing to embodiment of stress across generations.
C1 [Clausing, Elizabeth S.; Non, Amy L.] Univ Calif San Diego UCSD, Dept Anthropol, La Jolla, CA 92093 USA.
C3 University of California System; University of California San Diego
RP Non, AL (corresponding author), Univ Calif San Diego UCSD, Dept Anthropol, La Jolla, CA 92093 USA.
EM alnon@ucsd.edu
RI Non, Amy/AAW-7116-2021
CR ADLER NE, 1994, AM PSYCHOL, V49, P15, DOI 10.1037/0003-066X.49.1.15
   Baltrus PT, 2010, ETHNIC DIS, V20, P376
   Batalova Jeanne, 2021, Migration Information Source
   Beach SRH, 2011, PSYCHOSOM MED, V73, P83, DOI 10.1097/PSY.0b013e3181fdd074
   Beach SRH, 2010, AM J MED GENET B, V153B, P710, DOI 10.1002/ajmg.b.31028
   Bennett AJ, 2002, MOL PSYCHIATR, V7, P118, DOI 10.1038/sj/mp/4000949
   BERKMAN LF, 1979, AM J EPIDEMIOL, V109, P186, DOI 10.1093/oxfordjournals.aje.a112674
   Binder EB, 2008, JAMA-J AM MED ASSOC, V299, P1291, DOI 10.1001/jama.299.11.1291
   Bjorntorp P, 1988, Acta Med Scand Suppl, V723, P121
   BJORNTORP P, 1992, ANN MED, V24, P15, DOI 10.3109/07853899209164140
   Bogdan R, 2014, J CHILD PSYCHOL PSYC, V55, P448, DOI 10.1111/jcpp.12142
   Booij L, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0119061
   Braga DL, 2020, BIOGERONTOLOGY, V21, P423, DOI 10.1007/s10522-020-09874-y
   Bustamante AC, 2018, J PSYCHIATR RES, V96, P39, DOI 10.1016/j.jpsychires.2017.09.016
   Carver CS, 2010, CLIN PSYCHOL REV, V30, P879, DOI 10.1016/j.cpr.2010.01.006
   Clausing ES, 2020, EPIGENOMICS-UK, V13, DOI 10.2217/epi-2019-0343
   Creighton MJ, 2012, SOC SCI MED, V75, P300, DOI 10.1016/j.socscimed.2012.03.013
   Czyz W, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-93
   Delavari M, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-458
   Devlin AM, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012201
   Drabe M, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/tp.2017.133
   Dunn EC, 2019, BIOL PSYCHIAT, V85, P838, DOI 10.1016/j.biopsych.2018.12.023
   Eknoyan G, 2008, NEPHROL DIAL TRANSPL, V23, P47, DOI 10.1093/ndt/gfm517
   Ellison J, 2011, J CANCER EDUC, V26, P478, DOI 10.1007/s13187-011-0233-z
   Ey S, 2005, J CHILD PSYCHOL PSYC, V46, P548, DOI 10.1111/j.1469-7610.2004.00372.x
   Farrell C, 2018, PSYCHIAT RES, V265, P341, DOI 10.1016/j.psychres.2018.04.064
   Fox M, 2015, AM J PUBLIC HEALTH, V105, pS409, DOI 10.2105/AJPH.2015.302571
   Frodl T, 2015, J PSYCHIATR NEUROSCI, V40, P296, DOI 10.1503/jpn.140180
   Garza JR, 2017, J IMMIGR MINOR HEALT, V19, P108, DOI 10.1007/s10903-016-0346-x
   Geronimus AT, 2006, AM J PUBLIC HEALTH, V96, P826, DOI 10.2105/AJPH.2004.060749
   Goosby BJ, 2013, SOCIOL COMPASS, V7, P630, DOI 10.1111/soc4.12054
   Gordon-Larsen P, 2003, SOC SCI MED, V57, P2023, DOI 10.1016/S0277-9536(03)00072-8
   Harms MB, 2017, DEV PSYCHOPATHOL, V29, P1895, DOI 10.1017/S095457941700147X
   Hovey JD, 1996, J AM ACAD CHILD PSY, V35, P1183, DOI 10.1097/00004583-199609000-00016
   Howard S, 2017, BIOL PSYCHOL, V125, P70, DOI 10.1016/j.biopsycho.2017.02.006
   Huang Y, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008888
   Hunte HER, 2011, AM J EPIDEMIOL, V173, P1232, DOI 10.1093/aje/kwq463
   Jans LAW, 2007, MOL PSYCHIATR, V12, P522, DOI 10.1038/sj.mp.4001920
   Janssen I, 2004, AM J CLIN NUTR, V79, P379
   Kang HJ, 2013, PROG NEURO-PSYCHOPH, V44, P23, DOI 10.1016/j.pnpbp.2013.01.006
   Karg K, 2011, ARCH GEN PSYCHIAT, V68, P444, DOI 10.1001/archgenpsychiatry.2010.189
   Kaur G, 2019, ARCH TOXICOL, V93, P2715, DOI 10.1007/s00204-019-02562-y
   Kertes DA, 2016, CHILD DEV, V87, P61, DOI 10.1111/cdev.12487
   Klengel T, 2013, NAT NEUROSCI, V16, P33, DOI 10.1038/nn.3275
   Klinger-König J, 2019, NEUROPSYCHOPHARMACOL, V44, P930, DOI 10.1038/s41386-019-0319-6
   Krieger N, 2005, SOC SCI MED, V61, P1576, DOI 10.1016/j.socscimed.2005.03.006
   Krieger N, 2005, J EPIDEMIOL COMMUN H, V59, P350, DOI 10.1136/jech.2004.024562
   Kumanyika SK, 2014, OBES REV, V15, P204, DOI 10.1111/obr.12213
   Kuzawa CW, 2009, AM J HUM BIOL, V21, P2, DOI 10.1002/ajhb.20822
   Lillycrop KA, 2019, INT J OBESITY, V43, P974, DOI 10.1038/s41366-018-0254-3
   Liu JH, 2009, ETHNIC HEALTH, V14, P509, DOI 10.1080/13557850902890209
   McGregor K, 2016, GENOME BIOL, V17, DOI 10.1186/s13059-016-0935-y
   Miller O, 2020, PSYCHOL TRAUMA-US, V12, P750, DOI 10.1037/tra0000574
   Moyer AM, 2015, GENET TEST MOL BIOMA, V19, P115, DOI 10.1089/gtmb.2014.0250
   Needham BL, 2015, EPIGENETICS-US, V10, P958, DOI 10.1080/15592294.2015.1085139
   Negy C, 2009, CULT DIVERS ETHN MIN, V15, P255, DOI 10.1037/a0015109
   Non AL, 2021, EPIGENOMICS-UK, V13, P1747, DOI 10.2217/epi-2020-0136
   Non AL, 2020, INT J BEHAV MED, V27, P200, DOI 10.1007/s12529-020-09849-w
   Non AL, 2019, ETHNIC HEALTH, V24, P378, DOI 10.1080/13557858.2017.1346184
   Non AL, 2016, AM J PHYS ANTHROPOL, V161, P84, DOI 10.1002/ajpa.23010
   Office of minority health, 2019, OB HISP AM
   Ogden CL, 2016, JAMA-J AM MED ASSOC, V315, P2292, DOI 10.1001/jama.2016.6361
   Olukotun O, 2020, INT J QUAL METH, V19, DOI 10.1177/1609406920904575
   Ortiz R, 2018, CLIN EPIGENETICS, V10, DOI 10.1186/s13148-018-0513-0
   Ostrove JM, 2000, HEALTH PSYCHOL, V19, P613, DOI 10.1037/0278-6133.19.6.613
   Pan TM, 2017, J PSYCHOPATHOL BEHAV, V39, P657, DOI 10.1007/s10862-017-9606-x
   Parade SH, 2021, TRANSL PSYCHIAT, V11, DOI 10.1038/s41398-021-01207-y
   Perez DJ, 2008, J COMMUNITY PSYCHOL, V36, P421, DOI 10.1002/jcop.20221
   Priest N, 2020, BRAIN BEHAV IMMUN, V87, P660, DOI 10.1016/j.bbi.2020.02.012
   Provençal N, 2012, J NEUROSCI, V32, P15626, DOI 10.1523/JNEUROSCI.1470-12.2012
   Santos HP, 2018, PSYCHONEUROENDOCRINO, V98, P131, DOI 10.1016/j.psyneuen.2018.08.014
   Segal NL, 2017, EPIGENOMICS-UK, V9, P5, DOI 10.2217/epi-2016-0104
   Serlachius AS, 2016, J HEALTH PSYCHOL, V21, P1157, DOI 10.1177/1359105314547940
   Skinner AC, 2014, JAMA PEDIATR, V168, P561, DOI 10.1001/jamapediatrics.2014.21
   Tate EB, 2015, OBES REV, V16, P351, DOI 10.1111/obr.12262
   Topart C, 2020, CLIN EPIGENETICS, V12, DOI 10.1186/s13148-020-00893-7
   Wang YZ, 2018, EPIGENETICS-US, V13, P975, DOI 10.1080/15592294.2018.1526028
   Williams D R, 1997, J Health Psychol, V2, P335, DOI 10.1177/135910539700200305
   Yehuda R, 2016, BIOL PSYCHIAT, V80, P372, DOI 10.1016/j.biopsych.2015.08.005
   Zannas AS, 2014, GENES BRAIN BEHAV, V13, P25, DOI 10.1111/gbb.12104
   Zannas AS, 2019, P NATL ACAD SCI USA, V116, P11370, DOI 10.1073/pnas.1816847116
   Zannas AS, 2015, GENOME BIOL, V16, DOI 10.1186/s13059-015-0828-5
   Zhao J, 2013, INT J OBESITY, V37, P140, DOI 10.1038/ijo.2012.8
NR 83
TC 11
Z9 12
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JUL 20
PY 2021
VL 12
AR 696827
DI 10.3389/fpsyt.2021.696827
PG 14
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA XJ6IE
UT WOS:000726888300001
PM 34354616
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kizilay, DÖ
   Sapmaz, SY
   Sen, S
   Özkan, Y
   Ersoy, B
AF Kizilay, Deniz Ozalp
   Sapmaz, Sermin Yalin
   Sen, Semra
   Ozkan, Yekta
   Ersoy, Betal
TI Insulin Resistance as Related to Psychiatric Disorders in Obese Children
SO JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
LA English
DT Article
DE Child; obesity; insulin resistance; mental disorder
ID NATIONALLY REPRESENTATIVE SAMPLE; METABOLIC SYNDROME; CHILDHOOD OBESITY;
   DEPRESSIVE SYMPTOMS; PHYSICAL-ACTIVITY; MENTAL-HEALTH; ANXIETY;
   ADOLESCENTS; OVERWEIGHT; RISK
AB Objective: The current study aimed to investigate psychiatric consequences of obesity and the relationship between componenets of the metabolic syndrome and psychiatric disorders in children. Our second aim was to elucidate which of the anthropometric parameters or metabolic components were most strongly associated with psychiatric disorders.
   Methods: The study included 88 obese and overweight children with a body mass index (BMI) greater than 85th percentile. The patients were evaluated for psychiatric disorders by a single child and adolescent psychiatrist. Forty patients diagnosed with psychiatric disorders and 48 patients with normal psychiatric evaluation were compared in terms of anthropometric and metabolic parameters. BMI, BMI-standard deviation score and BMI percentile, waist circumference, waist to hip ratio, blood pressure and pubertal stage of all patients were recorded. Fasting serum glucose, insulin, lipid profile and homeostatic model assessments of insulin resistance (HOMA-IR) were measured to evaluate the metabolic parameters. Serum and 24 hour urine cortisol levels were measured.
   Results: HOMA-IR in the group with psychiatric disorders was found to be significantly higher than in the group without psychiatric disorders (6.59 +/- 3.36 vs 5.21 +/- 2.67; p = 0.035). Other anthropometric measurements and metabolic parameters were not significantly different between the two groups.
   Conclusion: An understanding of the relationships between obesity related medical comorbidities and psychiatric pathologies is important to encourage patients and their families to make successful healthy lifestyle changes and for weight management in terms of appropriate treatment.
C1 [Kizilay, Deniz Ozalp] Cigli State Training Hosp, Clin Pediat, Div Pediat Endocrinol, Izmir, Turkey.
   [Sapmaz, Sermin Yalin; Ozkan, Yekta] Manisa Celal Bayar Univ, Fac Med, Dept Child & Adolescent Psychiat, Manisa, Turkey.
   [Sen, Semra] Manisa Celal Bayar Univ, Fac Med, Dept Pediat, Div Pediat Infect Dis, Manisa, Turkey.
   [Ersoy, Betal] Manisa Celal Bayar Univ, Fac Med, Dept Pediat, Div Pediat Endocrinol & Metab, Manisa, Turkey.
C3 Celal Bayar University; Celal Bayar University; Celal Bayar University
RP Sen, S (corresponding author), Manisa Celal Bayar Univ, Fac Med, Dept Pediat, Div Pediat Infect Dis, Manisa, Turkey.
EM drsemrasen@gmail.com
RI Ozkan, Yekta/GZK-9051-2022
OI Ozkan, Yekta/0000-0003-2220-9967
CR [Anonymous], 2002, HEALTH-LONDON
   Arnaldi G, 2010, NEUROENDOCRINOLOGY, V92, P86, DOI 10.1159/000314213
   Belue R, 2009, PEDIATRICS, V123, P697, DOI 10.1542/peds.2008-0687
   Britz B, 2000, INT J OBESITY, V24, P1707, DOI 10.1038/sj.ijo.0801449
   Carroll D, 2009, BIOL PSYCHIAT, V66, P91, DOI 10.1016/j.biopsych.2009.02.020
   Cole TJ, 2000, BMJ-BRIT MED J, V320, P1240, DOI 10.1136/bmj.320.7244.1240
   Cortese S, 2017, CURR PSYCHIAT REP, V19, DOI 10.1007/s11920-017-0754-1
   Cortese S, 2016, AM J PSYCHIAT, V173, P34, DOI 10.1176/appi.ajp.2015.15020266
   Daniels SR, 2009, INT J OBESITY, V33, pS60, DOI 10.1038/ijo.2009.20
   Daniels SR, 2006, FUTURE CHILD, V16, P47, DOI 10.1353/foc.2006.0004
   Erermis S, 2004, PEDIATR INT, V46, P296, DOI 10.1111/j.1442-200x.2004.01882.x
   Falkner Bonita, 1999, Ethnicity and Disease, V9, P284
   Fox CK, 2016, CLIN PEDIATR, V55, P1120, DOI 10.1177/0009922815615825
   Giltay EJ, 2007, J PSYCHOSOM RES, V63, P483, DOI 10.1016/j.jpsychores.2007.07.014
   Gokler B., 2004, Cocuk Genclik Ruh Sagligi Dergisi, V11, P109
   Halfon N, 2013, ACAD PEDIATR, V13, P6, DOI 10.1016/j.acap.2012.10.007
   Hamer M, 2012, MOL PSYCHIATR, V17, P940, DOI 10.1038/mp.2012.30
   Heiskanen TH, 2006, J CLIN PSYCHIAT, V67, P1422, DOI 10.4088/JCP.v67n0913
   Jokela M, 2014, MOL PSYCHIATR, V19, P910, DOI 10.1038/mp.2013.162
   Kaufman J, 1997, J AM ACAD CHILD PSY, V36, P980, DOI 10.1097/00004583-199707000-00021
   Kelishadi R, 2014, J RES MED SCI, V19, P993
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178, DOI 10.4088/JCP.v69n0202
   Lim CS, 2015, J DEV BEHAV PEDIATR, V36, P664, DOI 10.1097/DBP.0000000000000225
   Maheux P, 1997, INT J OBESITY, V21, P97, DOI 10.1038/sj.ijo.0800372
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pervanidou P, 2013, STRESS, V16, P34, DOI 10.3109/10253890.2012.689040
   Phillips CM, 2015, PSYCHONEUROENDOCRINO, V62, P47, DOI 10.1016/j.psyneuen.2015.07.168
   Puhl R.M., 2011, Childhood Obesity, V7, P359
   Pulgarón ER, 2013, CLIN THER, V35, pA18, DOI 10.1016/j.clinthera.2012.12.014
   Pulkki-Råback L, 2009, HEALTH PSYCHOL, V28, P108, DOI 10.1037/a0012646
   Rankin J, 2016, ADOLESC HEALTH MED T, V7, P125, DOI 10.2147/AHMT.S101631
   Reaven GM, 2005, CLIN CHEM, V51, P931, DOI 10.1373/clinchem.2005.048611
   Reilly JJ, 2003, ARCH DIS CHILD, V88, P748, DOI 10.1136/adc.88.9.748
   Roohafza H, 2012, INT J ENDOCRINOL, V2012, DOI 10.1155/2012/380902
   Sanders RH, 2015, EUR J PEDIATR, V174, P715, DOI 10.1007/s00431-015-2551-3
   Shinn EH, 2001, AM J HYPERTENS, V14, P660, DOI 10.1016/S0895-7061(01)01304-8
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Storch EA, 2007, J PEDIATR PSYCHOL, V32, P80, DOI 10.1093/jpepsy/jsj113
   Ströhle A, 2009, J NEURAL TRANSM, V116, P777, DOI 10.1007/s00702-008-0092-x
   Takeuchi T, 2009, DIABETES-METAB RES, V25, P762, DOI 10.1002/dmrr.1041
   Taner Y, 2009, TURKISH J PEDIATR, V51, P466
   TANNER JM, 1976, ARCH DIS CHILD, V51, P170, DOI 10.1136/adc.51.3.170
   Topcu S, 2016, J PEDIATR ENDOCR MET, V29, P357, DOI 10.1515/jpem-2015-0254
   Valerio G, 2006, NUTR METAB CARDIOVAS, V16, P279, DOI 10.1016/j.numecd.2005.12.007
   Wabitsch M, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-789
   Zimmet P, 2007, PEDIATR DIABETES, V8, P299, DOI 10.1111/j.1399-5448.2007.00271.x
NR 48
TC 3
Z9 3
U1 0
U2 3
PU GALENOS YAYINCILIK
PI FINDIKZADE
PA MOLLA GURANI MAHALLESI KACAMAK SOKAK NO 21, FINDIKZADE, ISTANBUL 34093,
   TURKEY
SN 1308-5727
EI 1308-5735
J9 J CLIN RES PEDIATR E
JI J. Clin Res. Pediatr. Endocrinol.
PD DEC
PY 2018
VL 10
IS 4
BP 364
EP 372
AR PMID 29789273
DI 10.4274/jcrpe.0055
PG 9
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA HC2YE
UT WOS:000451667000010
PM 29789273
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Küçük, L
   Kaya, H
   Çömez, T
   Kaçar, S
   Kutlu, Y
   Zülfikar, H
AF Kucuk, Leyla
   Kaya, Hatice
   Comez, Tuba
   Kacar, Selma
   Kutlu, Yasemin
   Zulfikar, Haluk
TI Eating Behaviors and Related Factors in Psychiatric Patients
SO ARCHIVES OF PSYCHIATRIC NURSING
LA English
DT Article
DE Mental disorder; Nutrition; Eating attitude
ID NUTRITIONAL-STATUS; METABOLIC SYNDROME; RISK-FACTORS; ORAL-HEALTH;
   DISORDERS; PEOPLE; SCHIZOPHRENIA; PREVALENCE; MORTALITY; ANXIETY
AB The aim of this study was to determine the risk of eating disorders and associated risk factors in individuals with psychiatric disorders. Patients who were hospitalized in a psychiatry clinic of the university hospital between the dates of February 2014 and July 2014 constitute sample for the study. The study sample consisted of a total of 216 patients. Data were collected using a questionnaire form and the Eating Attitude Test.
   The mean age of the patients was 37 +/- 0.5, and 56.9% of the patients were female. Problems in eating behavior were observed in 11.6% of the patients, and a statistically significant relationship was found between the risk of eating disorders and diagnosis, gender, exercise and self-perception of weight.
   The risk of eating disorders was more frequently observed in patients diagnosed with depression, in female patients with a self-perceived weight problem and do not exercise.
C1 [Kucuk, Leyla; Kutlu, Yasemin] Istanbul Univ, Florence Nightingale Nursing Fac, Mental Hlth & Psychiat Nursing Dept, Sisli, Turkey.
   [Kaya, Hatice] Istanbul Univ, Florence Nightingale Nursing Fac, Fundamental Nursing Dept, Sisli, Turkey.
   [Comez, Tuba] Istanbul Univ, Hlth Sci Inst, Mental Hlth & Psychiat Nursing Dept, Cerrahpasa, Turkey.
   [Kacar, Selma] Istanbul Univ, Cerrahpasa Med Fac, Mental Hlth Serv, Kocamustafapasa Istanbul, Turkey.
   [Zulfikar, Haluk] Istanbul Univ, Fac Econ, Beyazit, Turkey.
C3 Istanbul University - Cerrahpasa; Istanbul University; Istanbul
   University; Istanbul University - Cerrahpasa; Istanbul University -
   Cerrahpasa; Istanbul University; Istanbul University - Cerrahpasa;
   Istanbul University; Istanbul University
RP Küçük, L (corresponding author), Istanbul Univ, Florence Nightingale Nursing Fac, Mental Hlth & Psychiat Nursing Dept, Sisli, Turkey.
EM leylak73@istanbul.edu.tr; haticeka@istanbul.edu.tr;
   tuba-comez@hotmail.com; selmasenlikci@gmail.com; ykutlu@gmail.com;
   zulfikar@istanbul.edu.tr
RI Küçük, Leyla/C-9631-2019; zulfikar, haluk/AAE-1834-2020; Çömez İkican,
   Tuba/AGV-6883-2022; Kutlu, Yasemin/Q-6107-2017; Kaya, Hatice/I-2179-2016
OI COMEZ IKICAN, TUBA/0000-0003-0929-8168; Kucuk, Leyla/0000-0003-0102-2968
FU Istanbul University [BAP:21797]
FX We would like to thank all patients. We would also like to thank
   Istanbul University Scientific Research Projects ID:BAP:21797.
CR Arcelus J, 2011, ARCH GEN PSYCHIAT, V68, P724, DOI 10.1001/archgenpsychiatry.2011.74
   Balcioglu I, 2008, CERRAHPASA TIP FAKLT, V62, P341
   Beyer J, 2005, NEUROPSYCHOPHARMACOL, V30, P401, DOI 10.1038/sj.npp.1300608
   Blinder BJ, 2006, PSYCHOSOM MED, V68, P454, DOI 10.1097/01.psy.0000221254.77675.f5
   Brown S, 2000, BRIT J PSYCHIAT, V177, P212, DOI 10.1192/bjp.177.3.212
   Button EJ, 2010, INT J EAT DISORDER, V43, P387, DOI 10.1002/eat.20715
   Cimpean D, 2005, PSYCHIAT ANN, V35, P70
   Colton Craig W, 2006, Prev Chronic Dis, V3, pA42
   Couturier J., 2004, CANADIAN J CME   FEB, P81
   Cserjési R, 2009, APPETITE, V52, P535, DOI 10.1016/j.appet.2009.01.003
   Dalle Grave R, 2008, COMPR PSYCHIAT, V49, P346, DOI 10.1016/j.comppsych.2007.12.007
   Demirkol M. E., 2016, PSIKIYATRIDE GUNCEL, V8, P85
   Dickerson F, 2013, PSYCHIAT SERV, V64, P44, DOI [10.1176/appi.ps.001432012, 10.1176/appi.ps.201200143]
   Druss BG, 2010, AM J PSYCHIAT, V167, P151, DOI 10.1176/appi.ajp.2009.09050691
   Eraslan D., 2006, ANADOLU PSIKIYATR DE, V7, P167
   Erol N, 1989, PSIKOLOJI DERGISI, V7, P25
   Fairburn CG, 2003, LANCET, V361, P407, DOI 10.1016/S0140-6736(03)12378-1
   Fontenelle LF, 2003, PSYCHIAT RES, V119, P189, DOI 10.1016/S0165-1781(03)00127-6
   Godart NT, 2006, COMPR PSYCHIAT, V47, P91, DOI 10.1016/j.comppsych.2005.07.001
   Haddad PM, 2007, CNS DRUGS, V21, P911, DOI 10.2165/00023210-200721110-00004
   Halmi K.A., 2003, Eating Disorders, P1
   Hardy S, 2010, INT J MENT HEALTH NU, V19, P350, DOI 10.1111/j.1447-0349.2010.00686.x
   Heiskanen T, 2003, J CLIN PSYCHIAT, V64, P575, DOI 10.4088/JCP.v64n0513
   Higgins PA, 2006, AM J CRIT CARE, V15, P166, DOI 10.4037/ajcc2006.15.2.166
   Hoek HW, 2003, INT J EAT DISORDER, V34, P383, DOI 10.1002/eat.10222
   Jensen GL, 2008, JPEN-PARENTER ENTER, V32, P578, DOI 10.1177/0148607108321708
   Joiner TE, 2001, PSYCHOL SCI, V12, P371, DOI 10.1111/1467-9280.00369
   Kaya MC, 2009, NOROPSIKIYATRI ARS, V46, P13
   Kilic C., 1998, Turkiye Ruh Sagligi Profili: Eriskin nufusta ruhsal hastaliklarin yayginligi, iliskili faktorler, yetiyitimi ve ruh sagligi hizmeti kullanimi sonuclari, P77
   Kisa C, 2008, NEW S J, V46, P66
   Kucukgoncu S, 2014, NOROPSIKIYATRI ARS, V51, P368, DOI 10.5152/npa.2014.7204
   Kurtzthaler I., 2001, J CLIN PSYCHIAT S7, V62, P1
   Lakhan SE, 2008, NUTR J, V7, DOI 10.1186/1475-2891-7-2
   Leung MW, 2010, PSYCHOSOMATICS, V51, P498, DOI 10.1176/appi.psy.51.6.498
   Mason TB, 2016, COMPR PSYCHIAT, V68, P165, DOI 10.1016/j.comppsych.2016.04.013
   Matevosyan NR, 2010, COMMUNITY MENT HLT J, V46, P553, DOI 10.1007/s10597-009-9280-x
   McCreadie RG, 2004, ACTA PSYCHIAT SCAND, V110, P306, DOI 10.1111/j.1600-0447.2004.00373.x
   McCreadie RG, 2003, BRIT J PSYCHIAT, V183, P534, DOI 10.1192/bjp.183.6.534
   Mischoulon D, 2011, J AFFECT DISORDERS, V130, P470, DOI 10.1016/j.jad.2010.10.043
   Mond JM, 2009, AUST NZ J PSYCHIAT, V43, P227, DOI 10.1080/00048670802653323
   Muir-Cochrane E, 2006, J PSYCHIATR MENT HLT, V13, P447, DOI 10.1111/j.1365-2850.2006.01002.x
   Murray CJL, 2012, LANCET, V380, P2197, DOI 10.1016/S0140-6736(12)61729-2
   Ozgur G., 2008, ATATURK U HEMSIRELIK, V11, P77
   Ozsoylar G, 2008, KLIN PSIKIYATR, V11, P17
   Potter P.A., 2009, Fundamentals of nursing
   Sagman D, 2010, BMC PSYCHIATRY, V10, DOI 10.1186/1471-244X-10-24
   Saleem M., 2014, Pakistan Journal of Commerce Social Sciences, V8, P925
   Sansone RA, 2010, NUTR CLIN PRACT, V25, P116, DOI 10.1177/0884533609357563
   Semiz M., 2012, TURK PSIKIYATR DERG, V24, P149
   Simonelli-Muñoz AJ, 2012, INT J MENT HEALTH NU, V21, P220, DOI 10.1111/j.1447-0349.2012.00821.x
   Sjögren R, 2000, J CLIN NURS, V9, P632, DOI 10.1046/j.1365-2702.2000.00380.x
   Spindler Anja, 2007, Eat Behav, V8, P364, DOI 10.1016/j.eatbeh.2006.11.012
   Taylor C., 2011, Fundamentals of nursing: The art and science of nursing care, V7th
   Tsai AC, 2011, J CLIN NURS, V20, P341, DOI 10.1111/j.1365-2702.2010.03467.x
   Turner H, 2016, BEHAV RES THER, V77, P1, DOI 10.1016/j.brat.2015.11.011
   Vos T, 2012, LANCET, V380, P2163, DOI 10.1016/S0140-6736(12)61729-2
   Wallace B, 1998, AUST NZ J PSYCHIAT, V32, P82, DOI 10.3109/00048679809062711
   World Health Organization, 2021, World report on hearing
   Yuksel CT, 2012, PSIKIYATRI HEMSIRELI, V3, P67
   Zimmermann U, 2003, J PSYCHIATR RES, V37, P193, DOI 10.1016/S0022-3956(03)00018-9
NR 60
TC 8
Z9 8
U1 0
U2 16
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0883-9417
EI 1532-8228
J9 ARCH PSYCHIAT NURS
JI Arch. Psychiatr. Nurs.
PD APR
PY 2018
VL 32
IS 2
BP 194
EP 199
DI 10.1016/j.apnu.2017.10.015
PG 6
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA GB6ML
UT WOS:000429183200005
PM 29579512
DA 2025-06-11
ER

PT J
AU Rhim, E
   Han, K
   Yun, KI
AF Rhim, Eunmi
   Han, Kyungdo
   Yun, Kyoung-In
TI Association between temporomandibular disorders and obesity
SO JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
LA English
DT Article
DE Cross-sectional studies; Population statistics; Temporomandibular joint
   disorder; Body mass index; Waist circumference
ID BODY-MASS-INDEX; PSYCHOLOGICAL STRESS; WAIST CIRCUMFERENCE; BITE FORCE;
   WEIGHT; WOMEN; ADOLESCENTS; PATTERNS; GENDER; HEALTH
AB Psychological stress can induce altered eating patterns, and studies have indicated that there is a correlation between temporomandibular disorder (TMD) and psychological stress. This study investigated the relationship between TMD and body mass index (BMI) in a large representative sample of the South Korean population using data from the Korea National Health and Nutrition Examination Survey (KNHANES). Men and women with TMD showed decreased prevalence of abdominal obesity. Women with TMD had lower age, lower BMI, lower metabolic syndromic waist circumference, lower prevalence of metabolic syndrome, and lower prevalence of diabetes compared with the group without TMD. However, males with TMD didn't show any statistically significant difference between BMI, and metabolic syndromic waist circumference compared with the group without TMD, although there were similar tendencies in the female subject groups. Overall, TMD was associated with decreased BMI and abdominal obesity in women. (C) 2016 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
C1 [Rhim, Eunmi] Catholic Univ Korea, Yeouido St Marys Hosp, Dept Conservat Dent & Endodont, Seoul, South Korea.
   [Han, Kyungdo] Catholic Univ Korea, Coll Med, Dept Biostat, Seoul, South Korea.
   [Yun, Kyoung-In] Catholic Univ Korea, Yeouido St Marys Hosp, Dept Oral & Maxillofacial Surg, Seoul, South Korea.
C3 Catholic University of Korea; Catholic University of Korea; Catholic
   University of Korea
RP Yun, KI (corresponding author), Catholic Univ Korea, Yeouido St Marys Hosp, Dept Oral & Maxillofacial Surg, Seoul, South Korea.
EM yun_ki@catholic.ac.kr
RI Han, Kyungdo/JKH-7628-2023
FU Institute of Clinical Medicine Research in the Catholic University of
   Korea, Yeouido St. Mary's Hospital
FX This study was funded by research grant from Institute of Clinical
   Medicine Research in the Catholic University of Korea, Yeouido St.
   Mary's Hospital. The authors thank the Korea Centers of Disease Control
   and Prevention for providing the data. The authors declare no potential
   conflicts of interest with respect to the authorship and/or publication
   of this article.
CR [Anonymous], 1987, Oral Health Surveys: Basic methods, V3rd
   BELLISLE F, 1981, PHYSIOL BEHAV, V27, P649, DOI 10.1016/0031-9384(81)90237-7
   Choi JY, 2013, MENOPAUSE, V20, P85, DOI 10.1097/gme.0b013e31825d26b6
   Chun YH, 2013, LIPIDS HEALTH DIS, V12, DOI 10.1186/1476-511X-12-84
   Epel E, 2004, ANN NY ACAD SCI, V1032, P208, DOI 10.1196/annals.1314.022
   Faraday MM, 2005, PHARMACOL BIOCHEM BE, V80, P577, DOI 10.1016/j.pbb.2005.01.015
   Haque Z, 2014, JCPSP-J COLL PHYSICI, V24, P705, DOI 10.2014/JCPSP.705709
   Irving J, 1999, Dent Update, V26, P405
   Jeon JY, 2013, DIABETES METAB J, V37, P349, DOI 10.4093/dmj.2013.37.5.349
   Kim MK, 2014, ENDOCRINOL METAB, V29, P405, DOI 10.3803/EnM.2014.29.4.405
   Kim YH, 2013, ARCH OSTEOPOROS, V8, DOI 10.1007/s11657-013-0142-3
   Kivimäki M, 2006, INT J OBESITY, V30, P982, DOI 10.1038/sj.ijo.0803229
   Kogawa EM, 2006, J ORAL REHABIL, V33, P559, DOI 10.1111/j.1365-2842.2006.01619.x
   Macht M, 2008, APPETITE, V50, P1, DOI 10.1016/j.appet.2007.07.002
   Makhija SK, 2007, J AM GERIATR SOC, V55, P1808, DOI 10.1111/j.1532-5415.2007.01391.x
   Murakami K, 2007, AM J CLIN NUTR, V86, P206, DOI 10.1093/ajcn/86.1.206
   Murray H, 1995, J OROFAC PAIN, V10, P316
   Nam GE, 2012, NUTR RES, V32, P395, DOI 10.1016/j.nutres.2012.05.002
   Newby P, 2003, AM J CLIN NUTR, V77, P1417, DOI 10.1093/ajcn/77.6.1417
   Nguyen-Rodriguez Selena T, 2008, Eat Behav, V9, P238, DOI 10.1016/j.eatbeh.2007.09.001
   Oral K, 2009, AGRI, V21, P89
   Pereira LJ, 2007, EUR J ORTHODONT, V29, P72, DOI 10.1093/ejo/cjl055
   Roberts C, 2007, OBESITY, V15, P3045, DOI 10.1038/oby.2007.363
   Roberts SB, 2002, J AM COLL NUTR, V21, p140S, DOI 10.1080/07315724.2002.10719211
   Santis T., 2011, BRAZJORAL, V9, P459
   Sinn DP, 1996, J ORAL MAXIL SURG, V54, P671, DOI 10.1016/S0278-2391(96)90678-3
   Spiegel TA, 2000, NEUROSCI BIOBEHAV R, V24, P229, DOI 10.1016/S0149-7634(99)00076-7
   Wang JJ, 2007, SOC COGN AFFECT NEUR, V2, P227, DOI 10.1093/scan/nsm018
   Weber MA, 2004, LANCET, V363, P2049, DOI 10.1016/S0140-6736(04)16456-8
   WILLNER P, 1987, PSYCHOPHARMACOLOGY, V93, P358
   WING RR, 1985, PSYCHOSOM MED, V47, P558, DOI 10.1097/00006842-198511000-00005
   WING RR, 1990, HEALTH PSYCHOL, V9, P693, DOI 10.1037/0278-6133.9.6.693
   Wright LJ, 2010, J PAIN, V11, P628, DOI 10.1016/j.jpain.2009.10.004
   Young EA, 2004, ANN NY ACAD SCI, V1021, P124, DOI 10.1196/annals.1308.013
   Yun KI, 2008, J ORAL MAXIL SURG, V66, P882, DOI 10.1016/j.joms.2008.01.034
NR 35
TC 26
Z9 28
U1 0
U2 6
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1010-5182
EI 1878-4119
J9 J CRANIO MAXILL SURG
JI J. Cranio-MaxilloFac. Surg.
PD AUG
PY 2016
VL 44
IS 8
BP 1003
EP 1007
DI 10.1016/j.jcms.2016.04.016
PG 5
WC Dentistry, Oral Surgery & Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine; Surgery
GA DT2PF
UT WOS:000381322200016
PM 27349686
DA 2025-06-11
ER

PT J
AU Rafiee, P
   Rasaei, N
   Amini, MR
   Rabiee, R
   Kalantar, Z
   Sheikhhossein, F
   Gholizadeh, M
   Hekmatdoost, A
AF Rafiee, Pegah
   Rasaei, Niloufar
   Amini, Mohammad Reza
   Rabiee, Reyhaneh
   Kalantar, Zahra
   Sheikhhossein, Fatemeh
   Gholizadeh, Mohammad
   Hekmatdoost, Azita
TI The effects of ursolic acid on cardiometabolic risk factors: a
   systematic review and meta-analysis
SO FUTURE CARDIOLOGY
LA English
DT Review
DE cardiometabolic risk factors; meta-analysis; ursolic acid
ID TYROSINE-PHOSPHATASE 1B; CARDIOVASCULAR RISK; METABOLIC SYNDROME; MUSCLE
   STRENGTH; DOUBLE-BLIND; INFLAMMATION; DIET; MASS
AB Aim: Ursolic acid (UA) has an important biological role in the fight against fat accumulation, insulin resistance, obesity and inflammation. Therefore, in the current review and meta-analysis work, we investigate the effects of UA (dosage range is 50.94 to 450 mg/day) on cardiometabolic risk factors. Materials & methods: After searching the studies up to February 2023, six articles were included in the study. Results: The pooled effect size showed that UA supplementation didn't significantly change body weight, body mass index, waist circumference, body fat percentage, lean body mass, systolic blood pressure, diastolic blood pressure, fasting blood glucose, insulin, triglycer ide and high-density lipoprotein compared with control groups. Conclusion: UA supplementation had no significant effect on the cardiometabolic risk factors in adults.
   Plain language summary: Cardiovascular disease (CVD) is a significant reason for morbidity and mortality. Ursolic acid (UA) has been shown to play important biological roles in the fight against fat accumulation, oxidative stress, insulin resistance via insulin-like growth factor 1, cancer, muscle atrophy, obesity and inflammation responsible for CVD. A systematic review and meta-analysis were conducted up to February 2023; six articles were included in the study and eleven cardiometabolic risk factors were identified. The pooled effect size showed that UA supplementation (dosage range is 50.94 to 450 mg/day) didn't significantly change body weight, body mass index, waist circumference, body fat percentage, lean body mass, systolic blood pressure, diastolic blood pressure, fasting blood glucose, insulin, triglyceride, and high-density lipoprotein compared with control groups.
C1 [Rafiee, Pegah; Amini, Mohammad Reza] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr & Food Technol, Dept Clin Nutr & Dietet,Student Res Comm, Tehran 1981619573, Iran.
   [Rasaei, Niloufar] Tehran Univ Med Sci IC TUMS, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran 141556117, Iran.
   [Rasaei, Niloufar] Universal Sci Educ & Res Network USERN, Network Interdisciplinar Neonates & Infants NINI, Tehran 141556117, Iran.
   [Amini, Mohammad Reza] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Nutr & Food Secur Res Ctr, Esfahan 1981619573, Iran.
   [Amini, Mohammad Reza] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan 1981619573, Iran.
   [Rabiee, Reyhaneh] Shahid Sadoughi Univ Med Sci, Student Res Comm, Sch Publ Hlth, Dept Nutr, Yazd 8915173160, Iran.
   [Kalantar, Zahra; Sheikhhossein, Fatemeh] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran 141556117, Iran.
   [Gholizadeh, Mohammad; Hekmatdoost, Azita] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Dept Clin Nutr & Dietet, Tehran 1981619573, Iran.
C3 Shahid Beheshti University Medical Sciences; Universal Scientific
   Education & Research Network (USERN); Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Shahid Sadoughi
   University of Medical Sciences; Tehran University of Medical Sciences;
   Shahid Beheshti University Medical Sciences
RP Hekmatdoost, A (corresponding author), Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Dept Clin Nutr & Dietet, Tehran 1981619573, Iran.
EM A_hekmat2000@yahoo.com
RI Amini, Mohammad/ABD-9638-2020; rafiee, pegah/JOK-5745-2023; Gholizadeh,
   Mohammad/KGL-1509-2024; Hekmatdoost, Azita/AGM-6497-2022
OI Kalantar, Zahra/0000-0001-6285-4835; Gholizadeh,
   Mohammad/0000-0001-9710-5068; Hekmatdoost, Azita/0000-0002-1944-0052;
   Amini, Mohammad Reza/0000-0003-0640-2142; Rabiee,
   Reyhaneh/0009-0007-9292-8306
FU Student Research Committee, Shahid Beheshti University of Medical
   Sciences, Tehran, Iran [1401/59204]; Shahid Beheshti University of
   Medical Sciences
FX This study is related to project NO. 1401/59204 From Student Research
   Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
   We also appreciate the 'Student Research Committee' and 'Research &
   Technology Chancellor' at Shahid Beheshti University of Medical Sciences
   for their financial support of this study. The authors have no other
   relevant affiliations or financial involvement with any organization or
   entity with a financial interest in or financial conflict with the
   subject matter or materials discussed in the manuscript apart from those
   disclosed.
CR Asghari Ehsan, 2020, Cardiovascular & Hematological Disorders - Drug Targets, V20, P138, DOI 10.2174/1871529X19666190918144727
   Bang HS, 2017, KOREAN J PHYSIOL PHA, V21, P651, DOI 10.4196/kjpp.2017.21.6.651
   Bang HS, 2014, KOREAN J PHYSIOL PHA, V18, P441, DOI 10.4196/kjpp.2014.18.5.441
   Booth A, 2011, LANCET, V377, P108, DOI 10.1016/S0140-6736(10)60903-8
   Chen JH, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/924128
   Cho YH, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/4301621
   Cione JGC, 2021, CLIN NUTR ESPEN, V44, P143, DOI 10.1016/j.clnesp.2021.05.031
   Dicker D, 2018, LANCET, V392, P1684, DOI 10.1016/s0140-6736(18)31891-9
   Egger M, 1997, BMJ-BRIT MED J, V315, P629, DOI 10.1136/bmj.315.7109.629
   Erdmann J, 2021, NUTRIENTS, V13, DOI 10.3390/nu13113900
   Gai L, 2013, MOL MED REP, V7, P1673, DOI 10.3892/mmr.2013.1364
   Geerlofs L, 2020, TOXICOL REP, V7, P610, DOI 10.1016/j.toxrep.2020.04.005
   Gholami F, 2022, BMC CARDIOVASC DISOR, V22, DOI 10.1186/s12872-022-02888-z
   HAN TS, 1995, BRIT MED J, V311, P1401, DOI 10.1136/bmj.311.7017.1401
   Higgins Julian P T, 2011, BMJ, V343, pd5928, DOI 10.1136/bmj.d5928
   Hirsh S., 2014, The FASEB Journal, V28, p1044.6, DOI [DOI 10.1096/FASEBJ.28.1_SUPPLEMENT.1044.6, 10.1096/fasebj.28.1supplement.1044.6]
   Hozo SP., 2005, BMC MED RES METHODOL, V5, DOI [10.1186/1471-2288-5-13, DOI 10.1186/1471-2288-5-13]
   Nguyen HN, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10081161
   Jain M, 2003, CIRC RES, V93, pE9, DOI 10.1161/01.RES.0000083489.83704.76
   Kashyap D, 2016, LIFE SCI, V146, P201, DOI 10.1016/j.lfs.2016.01.017
   Kim J, 2009, ARCH PHARM RES, V32, P983, DOI 10.1007/s12272-009-1702-3
   Kim SH, 2013, EUR J PHARMACOL, V701, P131, DOI 10.1016/j.ejphar.2012.11.033
   Kunkel SD, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039332
   Kunkel SD, 2011, CELL METAB, V13, P627, DOI 10.1016/j.cmet.2011.03.020
   Li Di, 2012, Zhong Xi Yi Jie He Xue Bao, V10, P886, DOI 10.3736/jcim20120809
   Liperoti R, 2017, J AM COLL CARDIOL, V69, P1188, DOI 10.1016/j.jacc.2016.11.078
   Liu H, 2005, J ETHNOPHARMACOL, V100, P92, DOI 10.1016/j.jep.2005.05.024
   Lobo PCB, 2021, CLIN NUTR, V40, P581, DOI 10.1016/j.clnu.2020.06.004
   Ma JQ, 2014, ENVIRON TOXICOL PHAR, V37, P975, DOI 10.1016/j.etap.2014.03.011
   Maron BJ, 2009, CIRCULATION, V119, P1085, DOI 10.1161/CIRCULATIONAHA.108.804617
   McMillan DC, 2006, BRIT MED J, V333, P1109, DOI 10.1136/bmj.39042.565035.BE1
   Mensah GA, 2019, J AM COLL CARDIOL, V74, P2529, DOI 10.1016/j.jacc.2019.10.009
   Mohammadpour S., 2020, Obes Med, V19, P100276, DOI [10.1016/j.obmed.2020.100276, DOI 10.1016/J.OBMED.2020.100276]
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Myers J, 2015, PROG CARDIOVASC DIS, V57, P306, DOI 10.1016/j.pcad.2014.09.011
   Organization WH., 2014, GLOBAL STATUS REPORT
   Potì F, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20020351
   Rahmani J, 2019, EUR J GASTROEN HEPAT, V31, P555, DOI [10.1097/MEG.0000000000001353, 10.1097/meg.0000000000001353]
   Ramírez-Rodríguez AM, 2017, J MED FOOD, V20, P882, DOI 10.1089/jmf.2017.0003
   Rao VS, 2011, J MED FOOD, V14, P1375, DOI 10.1089/jmf.2010.0267
   Rosengren A, 2004, LANCET, V364, P953, DOI 10.1016/S0140-6736(04)17019-0
   Roth GA, 2017, J AM COLL CARDIOL, V70, P1, DOI 10.1016/j.jacc.2017.04.052
   Senthil S, 2007, INT J CARDIOL, V119, P131, DOI 10.1016/j.ijcard.2006.07.108
   Shah MR, 2016, J ENZYM INHIB MED CH, V31, P563, DOI 10.3109/14756366.2015.1047358
   Somova LI, 2004, PHYTOMEDICINE, V11, P121, DOI 10.1078/0944-7113-00329
   Somova LO, 2003, PHYTOMEDICINE, V10, P115, DOI 10.1078/094471103321659807
   Sundaresan A, 2012, GEN PHYSIOL BIOPHYS, V31, P323, DOI 10.4149/gpb_2012_037
   Whitlock G, 2009, LANCET, V373, P1083, DOI 10.1016/S0140-6736(09)60318-4
   World Health Organization, 2014, WHO/NMH/NVI/15.1)
   Zhang W, 2006, BBA-GEN SUBJECTS, V1760, P1505, DOI 10.1016/j.bbagen.2006.05.009
   Zhao M, 2023, FRONT PHARMACOL, V14, DOI 10.3389/fphar.2023.1256946
NR 51
TC 1
Z9 1
U1 1
U2 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1479-6678
EI 1744-8298
J9 FUTUR CARDIOL
JI Futur. Cardiol.
PD FEB 17
PY 2024
VL 20
IS 3
BP 151
EP 161
AR 2349476
DI 10.1080/14796678.2024.2349476
EA MAY 2024
PG 11
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA WN9X6
UT WOS:001235362900001
PM 38923885
DA 2025-06-11
ER

PT J
AU Costa, JO
   Vasquez, CMP
   Santana, GD
   Silva, ND
   Braz, JD
   de Jesus, AMR
   da Silva, DG
   Cunha, LCS
   Barbosa, KBF
AF Costa, Jamille Oliveira
   Passos Vasquez, Cecilia M.
   Santana, Gleiciane de Jesus
   Silva, Natanael de Jesus
   Braz, Juciene de Matos
   Ribeiro de Jesus, Amelia M.
   da Silva, Danielle Goes
   Seraphim Cunha, Luana Celina
   Ferreira Barbosa, Kiriaque Barra
TI Plasma Total Antioxidant Capacity and Cardiometabolic Risk in Non-Obese
   and Clinically Healthy Young Adults
SO ARQUIVOS BRASILEIROS DE CARDIOLOGIA
LA English
DT Article
DE Cardiovascular Diseases; Risk Factors; Metabolic Syndrome; Oxidative
   Stress; Antioxidants; Young Adult
ID DENSITY-LIPOPROTEIN; CHOLESTEROL RATIO; PREDICTORS; TRIGLYCERIDES;
   CARBOHYDRATE; RESISTANCE; ENERGY
AB Background: The oxidative biomarkers play an important role in the genesis of cardiometabolic risk-related processes.
   Objective: To investigate the total antioxidant capacity of plasma and its association with cardiometabolic risk in non-obese and clinically healthy young adults.
   Methods: University students of the state of Sergipe, Brazil, aged between 18 and 25 years, were recruited for this study from May of 2013 and October of 2014. Anthropometric, clinical and biochemical parameters were measured and analyzed using protocols which were previously standardized and described in the literature. The measurement of plasma total antioxidant capacity was based on the ability that all the antioxidants present in the sample (plasma) have to inhibit the oxidation of the oxidizable substrate ABTS (2,2'-Azino-di-[3-ethylbenzthiazoline sulphonate]) to ABTS center dot+ by metmyoglobin.
   Results: Approximately 25% of the sample presented more than one component of cardiometabolic risk. Low HDL-cholesterol was the most prevalent component. Compared to absence of components, the subjects with at least one component presented greater body weight and waist circumference, higher levels of diastolic blood pressure and fasting glucose, greater total cholesterol/HDL-c ratio, and lower levels of HDL-c (p < 0.05). Fasting glycemia was the only parameter which was associated with total antioxidant capacity (R-2 = 0.10; beta = 0.17; p = 0.001).
   Conclusions: The plasma total antioxidant capacity was not able to predict the cardiometabolic risk components due possibly to the establishment of compensatory mechanisms that become activated in physiological conditions.
C1 [Costa, Jamille Oliveira; Passos Vasquez, Cecilia M.; Santana, Gleiciane de Jesus; Silva, Natanael de Jesus; Braz, Juciene de Matos; Ribeiro de Jesus, Amelia M.; da Silva, Danielle Goes; Seraphim Cunha, Luana Celina; Ferreira Barbosa, Kiriaque Barra] UFS, Aracaju, SE, Brazil.
RP Barbosa, KBF (corresponding author), Av Marechal Rondon S-N, BR-49100000 Sao Cristovao, SE, Brazil.
EM kiribarra@yahoo.com.br
RI Barbosa, Kiriaque/E-4269-2014; de Jesus Silva, Natanael/AAS-2223-2021
FU Fundacao de Apoio a Pesquisa e a Inovacao Tecnologica do Estado de
   Sergipe
FX This study was funded by Fundacao de Apoio a Pesquisa e a Inovacao
   Tecnologica do Estado de Sergipe.
CR [Anonymous], 2014, Revista da Sociedade Brasileira de Clinica Medica
   [Anonymous], IDF CONS WORLDW DEF
   [Anonymous], BIOMED RES INT
   [Anonymous], 1997, WHO TECHN REP SER
   [Anonymous], BR J NUTR S1
   [Anonymous], 2012, World health statistics: A snapshot of global health
   [Anonymous], REV BRASILEIRA CARDI
   [Anonymous], J NUTR METAB
   Bitla A.R., 2012, J. Clin. Res, V1, P114, DOI [10.4103/2277-5706.241431, DOI 10.15380/2277-5706.JCSR.12.032, DOI 10.4103/2277-5706.241431]
   Bloom D.E., 2011, The global economic burden of non-communicable diseases
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   D'Archivio M, 2012, EUR J CLIN INVEST, V42, P70, DOI 10.1111/j.1365-2362.2011.02558.x
   Demirbag R, 2005, MUTAT RES-FUND MOL M, V570, P197, DOI 10.1016/j.mrfmmm.2004.11.003
   Dziegielewska-Gesiak S, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/987303
   Barbosa KBF, 2014, NUTRITION, V30, P1349, DOI 10.1016/j.nut.2014.03.031
   Barbosa KBF, 2010, REV NUTR, V23, P629, DOI 10.1590/S1415-52732010000400013
   Finlayson G, 2012, APPETITE, V58, P1091, DOI 10.1016/j.appet.2012.03.003
   Flowers E, 2015, INDIAN J MED RES, V141, P68, DOI 10.4103/0971-5916.154506
   Frohlich J, 2003, CLIN CHEM, V49, P1873, DOI 10.1373/clinchem.2003.022558
   Gasparotto G.S., 2013, Medicina, V46, P154, DOI DOI 10.11606/issn.2176-7262.v46i2p154-163
   Gaziano JM, 1997, CIRCULATION, V96, P2520, DOI 10.1161/01.CIR.96.8.2520
   Gonzalez MM, 2013, ARQ BRAS CARDIOL, V101, P3
   Greene GW, 2011, J AM DIET ASSOC, V111, P394, DOI 10.1016/j.jada.2010.11.011
   Han JeongHwa Han JeongHwa, 2013, Korean Journal of Nutrition, V46, P126, DOI 10.4163/kjn.2013.46.2.126
   Kaefer M, 2012, CLIN LAB, V58, P973, DOI 10.7754/Clin.Lab.2012.111110
   Kaplan RC, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.114.000923
   Leiter LA, 2011, CAN J CARDIOL, V27, DOI 10.1016/j.cjca.2010.12.054
   Matsudo S., 2012, Rev Bras Ativ Fis Saude Internet, V6, P5, DOI DOI 10.12820/RBAFS.V.6N2P5-18
   Miot Hélio Amante, 2011, J. vasc. bras., V10, P275
   Moreno González Manuel Ignacio, 2010, Rev Chil Cardiol, V29, P85
   Muñoz A, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/610950
   Murguía-Romero M, 2013, J LIPID RES, V54, P2795, DOI 10.1194/jlr.M040584
   PERLOFF D, 1993, CIRCULATION, V88, P2460, DOI 10.1161/01.CIR.88.5.2460
   Ross AC, 2011, Dietary Reference Intakes for Calcium and Vitamin D, P1
   Topè AM, 2013, DIABETOL METAB SYNDR, V5, DOI 10.1186/1758-5996-5-2
   Trumbo P, 2002, J AM DIET ASSOC, V102, P1621, DOI 10.1016/S0002-8223(02)90346-9
   Vieira Eder Andrade, 2011, J. Bras. Patol. Med. Lab., V47, P113, DOI 10.1590/S1676-24442011000200004
   da Silva ARV, 2014, REV LAT-AM ENFERM, V22, P1041, DOI 10.1590/0104-1169.0129.2514
   Wärnberg J, 2006, AM J CLIN NUTR, V84, P505
   Miralles CSW, 2015, NUTR HOSP, V31, P2115, DOI 10.3305/nh.2015.31.5.7773
NR 40
TC 8
Z9 8
U1 0
U2 8
PU ARQUIVOS BRASILEIROS CARDIOLOGIA
PI RIO DE JANEIRO
PA AVENIDA MARECHAL CAMARA 160-330 CENTRO, RIO DE JANEIRO, RJ 20 020-907,
   BRAZIL
SN 0066-782X
EI 1678-4170
J9 ARQ BRAS CARDIOL
JI Arq. Bras. Cardiol.
PD AUG
PY 2017
VL 109
IS 2
BP 140
EP 146
DI 10.5935/abc.20170095
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FG9QY
UT WOS:000410775300008
PM 28700017
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Marco, EM
   García-Gutíerrez, MS
   Bermúdez-Silva, FJ
   Moreira, FA
   Guimaraes, F
   Manzanares, J
   Viveros, MP
AF Marco, Eva M.
   Garcia-Gutierrez, Maria S.
   Bermudez-Silva, Francisco-Javier
   Moreira, Fabricio A.
   Guimaraes, Francisco
   Manzanares, Jorge
   Viveros, Maria-Paz
TI Endocannabinoid system and psychiatry: in search of a neurobiological
   basis for detrimental and potential therapeutic effects
SO FRONTIERS IN BEHAVIORAL NEUROSCIENCE
LA English
DT Article
DE cannabinoid receptor; cannabidiol; cognition; emotion; anxiety;
   depression; schizophrenia; eating disorders
ID CANNABINOID CB1 RECEPTOR; DORSOLATERAL PERIAQUEDUCTAL GRAY; EARLY
   MATERNAL-DEPRIVATION; CARDIOMETABOLIC RISK-FACTORS; ANTERIOR CINGULATE
   CORTEX; BINGE-EATING DISORDER; ANXIETY-LIKE BEHAVIOR; ANOREXIA-NERVOSA;
   SOCIAL-ISOLATION; RAT-BRAIN
AB Public concern on mental health has noticeably increased given the high prevalence of neuropsychiatric disorders. Cognition and emotionality are the most affected functions in neuropsychiatric disorders, i.e., anxiety disorders, depression, and schizophrenia. In this review, most relevant literature on the role of the endocannabinoid (eCB) system in neuropsychiatric disorders will be presented. Evidence from clinical and animal studies is provided for the participation of CB1 and CB2 receptors (CB1R and CB2R) in the above mentioned neuropsychiatric disorders. CBRs are crucial in some of the emotional and cognitive impairments reported, although more research is required to understand the specific role of the eCB system in neuropsychiatric disorders. Cannabidiol (CBD), the main non-psychotropic component of the Cannabis sativa plant, has shown therapeutic potential in several neuropsychiatric disorders. Although further studies are needed, recent studies indicate that CBD therapeutic effects may partially depend on facilitation of eCB-mediated neurotransmission. Last but not least, this review includes recent findings on the role of the eCB system in eating disorders. A deregulation of the eCB system has been proposed to be in the bases of several neuropsychiatric disorders, including eating disorders. Cannabis consumption has been related to the appearance of psychotic symptoms and schizophrenia. In contrast, the pharmacological manipulation of this eCB system has been proposed as a potential strategy for the treatment of anxiety disorders, depression, and anorexia nervosa. In conclusion, the eCB system plays a critical role in psychiatry; however, detrimental consequences of manipulating this endogenous system cannot be underestimated over the potential and promising perspectives of its therapeutic manipulation.
C1 [Marco, Eva M.; Viveros, Maria-Paz] Univ Complutense Madrid, Fac Ciencias Biol, Dept Fisiol Fisiol Anim 2, E-28040 Madrid, Spain.
   [Marco, Eva M.; Viveros, Maria-Paz] Hosp Clin San Carlos, Inst Invest Sanitaria, Madrid, Spain.
   [Garcia-Gutierrez, Maria S.; Manzanares, Jorge] Univ Miguel Hernandez, Inst Neurociencias Alicante, CSIC, Alacant, Spain.
   [Bermudez-Silva, Francisco-Javier] Hosp Carlos Haya de Malaga, Fdn IMABIS, Lab Med Regenerat, Malaga, Spain.
   [Bermudez-Silva, Francisco-Javier] Univ Bordeaux 2, INSERM, Neuroctr Magendie, F-33076 Bordeaux, France.
   [Moreira, Fabricio A.] Univ Fed Minas Gerais, Inst Biol Sci, Dept Pharmacol, Belo Horizonte, MG, Brazil.
   [Guimaraes, Francisco] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pharmacol, BR-14049 Ribeirao Preto, SP, Brazil.
C3 Complutense University of Madrid; Hospital Clinico San Carlos; Consejo
   Superior de Investigaciones Cientificas (CSIC); Universidad Miguel
   Hernandez de Elche; CSIC-UMH - Instituto de Neurociencias de Alicante
   (IN); FIMABIS; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite de Bordeaux; Universidade Federal de Minas Gerais;
   Universidade de Sao Paulo
RP Marco, EM (corresponding author), Univ Complutense Madrid, Fac Ciencias Biol, Dept Fisiol Fisiol Anim 2, Ciudad Univ,C Jose Antonio Novais 2, E-28040 Madrid, Spain.
EM emmarco@bio.ucm.es; pazviver@bio.ucm.es
RI Guimaraes, Francisco/C-1059-2012; Gutiérrez, Maria/AAY-6406-2021; Marco,
   Eva/ABH-3257-2020; Marco, Eva M./K-8224-2015; Viveros,
   Maria-Paz/S-6855-2016; Bermudez-Silva, Francisco-Javier/Q-6920-2016
OI Marco, Eva M./0000-0002-2457-475X; Moreira,
   Fabricio/0000-0002-0824-7302; Manzanares, Jorge/0000-0003-3830-7107;
   Manzanares, Jorge/0000-0002-4681-1533; Garcia-Gutierrez, Maria
   Salud/0000-0001-6106-6247; Viveros, Maria-Paz/0000-0002-4119-4636;
   Bermudez-Silva, Francisco-Javier/0000-0003-3133-9691
FU National System of Health (Instituto de Salud Carlos III) [CP07/00283];
   Instituto de Salud Carlos III [BA09/90066]; Instituto de Salud Carlos
   III, Redes tematicas de Investigacion Cooperativa en salud (ISCIII y
   FEDER) [RD06/0001/1013, RD06/0001/1004]; Ministerio de Ciencia e
   Innovacion [BFU2009-10109, 951579]; Plan Nacional sobre Drogas
   [SAS/1250/2009]; Ministerio de Sanidad [10/02308]
FX Instituto de Salud Carlos III, Redes tematicas de Investigacion
   Cooperativa en salud (ISCIII y FEDER): RD06/0001/1013 and
   RD06/0001/1004; Ministerio de Ciencia e Innovacion: BFU2009-10109,
   GRUPOS UCM-BSCH (951579); Plan Nacional sobre Drogas SAS/1250/2009.
   Ministerio de Sanidad (10/02308). Francisco-Javier Bermudez-Silva is
   recipient of a research contract from the National System of Health
   (Instituto de Salud Carlos III; CP07/00283) and of a BAE from Instituto
   de Salud Carlos III (BA09/90066).
CR Aguiar DC, 2009, J NEUROSCI RES, V87, P2418, DOI 10.1002/jnr.22082
   Ahn K, 2008, CHEM REV, V108, P1687, DOI 10.1021/cr0782067
   Airaksinen E, 2007, ACTA PSYCHIAT SCAND, V115, P458, DOI 10.1111/j.1600-0447.2006.00932.x
   Akinshola BE, 1999, NEUROCHEM RES, V24, P1233, DOI 10.1023/A:1020968922151
   Alves FHF, 2010, PHARMACOL RES, V62, P228, DOI 10.1016/j.phrs.2010.05.003
   Amitai N, 2007, PSYCHOPHARMACOLOGY, V193, P521, DOI 10.1007/s00213-007-0808-x
   André A, 2010, INT J BIOCHEM CELL B, V42, P1788, DOI 10.1016/j.biocel.2010.06.002
   Arévalo C, 2001, PHARMACOL BIOCHEM BE, V70, P123, DOI 10.1016/S0091-3057(01)00578-0
   Aso E, 2008, J NEUROCHEM, V105, P565, DOI 10.1111/j.1471-4159.2007.05149.x
   Aso E, 2011, EUR NEUROPSYCHOPHARM, V21, P11, DOI 10.1016/j.euroneuro.2010.06.007
   Baker D, 2006, TRENDS PHARMACOL SCI, V27, P1, DOI 10.1016/j.tips.2005.11.003
   Bambico FR, 2008, EXPERT OPIN THER TAR, V12, P1347, DOI 10.1517/14728222.12.11.1347 
   Barch DM, 2005, ANNU REV CLIN PSYCHO, V1, P321, DOI 10.1146/annurev.clinpsy.1.102803.143959
   Barrero FJ, 2005, PHARMACOGENOMICS J, V5, P135, DOI 10.1038/sj.tpj.6500301
   BEAL JE, 1995, J PAIN SYMPTOM MANAG, V10, P89, DOI 10.1016/0885-3924(94)00117-4
   Bekker MHJ, 2007, GENDER MED, V4, pS178, DOI 10.1016/S1550-8579(07)80057-X
   Bergamaschi MM, 2011, NEUROPSYCHOPHARMACOL, V36, P1219, DOI 10.1038/npp.2011.6
   Bermudez-Silva FJ, 2010, PHARMACOL BIOCHEM BE, V95, P375, DOI 10.1016/j.pbb.2010.03.012
   Bermudez-Silva F. J., 2011, J PSYCHOPHARMACOL
   Berrendero F, 2002, PSYCHOPHARMACOLOGY, V163, P111, DOI 10.1007/s00213-002-1144-9
   Berry E. M., 2006, 6 NORD C EAT DIS AAR
   Bierman EJM, 2005, AM J GERIAT PSYCHIAT, V13, P686, DOI 10.1176/appi.ajgp.13.8.686
   Biscaia M, 2003, PSYCHOPHARMACOLOGY, V170, P301, DOI 10.1007/s00213-003-1550-7
   Bisogno T, 2001, BRIT J PHARMACOL, V134, P845, DOI 10.1038/sj.bjp.0704327
   Bitencourt RM, 2008, EUR NEUROPSYCHOPHARM, V18, P849, DOI 10.1016/j.euroneuro.2008.07.001
   Bortolato M, 2007, BIOL PSYCHIAT, V62, P1103, DOI 10.1016/j.biopsych.2006.12.001
   BOUABOULA M, 1995, J BIOL CHEM, V270, P13973, DOI 10.1074/jbc.270.23.13973
   Braff DL, 2001, PSYCHOPHARMACOLOGY, V156, P234, DOI 10.1007/s002130100810
   Braida D, 2007, EUR J PHARMACOL, V555, P156, DOI 10.1016/j.ejphar.2006.10.038
   Budney AJ, 2004, AM J PSYCHIAT, V161, P1967, DOI 10.1176/appi.ajp.161.11.1967
   Bulik CM, 1998, BIOL PSYCHIAT, V44, P1210, DOI 10.1016/S0006-3223(98)00280-7
   Burdyga G, 2004, J NEUROSCI, V24, P2708, DOI 10.1523/JNEUROSCI.5404-03.2004
   Campos A. C., 2010, CAN NEUROSCI
   Campos AC, 2008, PSYCHOPHARMACOLOGY, V199, P223, DOI 10.1007/s00213-008-1168-x
   Campos AC, 2009, PROG NEURO-PSYCHOPH, V33, P1517, DOI 10.1016/j.pnpbp.2009.08.017
   Carlisle SJ, 2002, INT IMMUNOPHARMACOL, V2, P69, DOI 10.1016/S1567-5769(01)00147-3
   Carrier E. J., 2007, INT CANN RES SOC ICR, P147
   Carrier EJ, 2006, P NATL ACAD SCI USA, V103, P7895, DOI 10.1073/pnas.0511232103
   Casarotto PC, 2010, BEHAV PHARMACOL, V21, P353, DOI 10.1097/FBP.0b013e32833b33c5
   CHAKRABARTI A, 1995, DNA SEQUENCE, V5, P385, DOI 10.3109/10425179509020870
   Chavarría-Siles I, 2008, AM J MED GENET B, V147B, P279, DOI 10.1002/ajmg.b.30592
   Chhatwal JP, 2005, NEUROPSYCHOPHARMACOL, V30, P516, DOI 10.1038/sj.npp.1300655
   Clément Y, 2002, BRAIN RES BULL, V57, P57, DOI 10.1016/S0361-9230(01)00637-2
   Cohen M, 2008, AUST NZ J PSYCHIAT, V42, P357, DOI 10.1080/00048670801961156
   Crippa JAD, 2004, NEUROPSYCHOPHARMACOL, V29, P417, DOI 10.1038/sj.npp.1300340
   Crippa JA, 2009, HUM PSYCHOPHARM CLIN, V24, P515, DOI 10.1002/hup.1048
   Cristino L, 2006, NEUROSCIENCE, V139, P1405, DOI 10.1016/j.neuroscience.2006.02.074
   D'Souza DC, 2009, EUR ARCH PSY CLIN N, V259, P413, DOI 10.1007/s00406-009-0024-2
   Da Settimo F, 2007, CURR MED CHEM, V14, P2680, DOI 10.2174/092986707782023190
   Davidson RJ, 2002, BIOL PSYCHIAT, V52, P478, DOI 10.1016/S0006-3223(02)01458-0
   Dean B, 2001, NEUROSCIENCE, V103, P9, DOI 10.1016/S0306-4522(00)00552-2
   Degenhardt L, 2003, ADDICTION, V98, P1493, DOI 10.1046/j.1360-0443.2003.00437.x
   Demirakca T, 2011, DRUG ALCOHOL DEPEN, V114, P242, DOI 10.1016/j.drugalcdep.2010.09.020
   Deng Chao, 2007, Neurosci Bull, V23, P341, DOI 10.1007/s12264-007-0051-9
   Dere E, 2010, BEHAV BRAIN RES, V215, P162, DOI 10.1016/j.bbr.2010.03.017
   DEROCQ JM, 1995, FEBS LETT, V369, P177, DOI 10.1016/0014-5793(95)00746-V
   Di Forti M, 2007, CURR OPIN PSYCHIATR, V20, P228
   Di Marzo V, 2001, NATURE, V410, P822, DOI 10.1038/35071088
   Di Marzo V, 2009, INT J OBESITY, V33, pS18, DOI 10.1038/ijo.2009.67
   DiPatrizio NV, 2008, J NEUROSCI, V28, P9702, DOI 10.1523/JNEUROSCI.1171-08.2008
   Doggrell SA, 2008, EXPERT OPIN PHARMACO, V9, P2727, DOI [10.1517/14656566.9.15.2727, 10.1517/14656566.9.15.2727 ]
   Domenici MR, 2006, J NEUROSCI, V26, P5794, DOI 10.1523/JNEUROSCI.0372-06.2006
   Egerton A, 2006, NEUROSCI BIOBEHAV R, V30, P680, DOI 10.1016/j.neubiorev.2005.12.002
   Eggan SM, 2008, ARCH GEN PSYCHIAT, V65, P772, DOI 10.1001/archpsyc.65.7.772
   Ehrhart J, 2005, J NEUROINFLAMM, V2, DOI 10.1186/1742-2094-2-29
   Ellenbroek BA, 2003, CLIN NEUROSCI RES, V3, P297, DOI 10.1016/S1566-2772(03)00090-2
   Fattore L, 2008, MOL CELL ENDOCRINOL, V286, pS97, DOI 10.1016/j.mce.2008.02.006
   Fernandez-Espejo E, 2009, PSYCHOPHARMACOLOGY, V206, P531, DOI 10.1007/s00213-009-1612-6
   Finn DP, 2010, IMMUNOBIOLOGY, V215, P629, DOI 10.1016/j.imbio.2009.05.011
   Fone KCF, 2008, NEUROSCI BIOBEHAV R, V32, P1087, DOI 10.1016/j.neubiorev.2008.03.003
   Frieling H, 2009, PSYCHONEUROENDOCRINO, V34, P620, DOI 10.1016/j.psyneuen.2008.10.014
   Fu J, 2003, NATURE, V425, P90, DOI 10.1038/nature01921
   Fusar-Poli P, 2010, INT J NEUROPSYCHOPH, V13, P421, DOI 10.1017/S1461145709990617
   Fusar-Poli P, 2009, ARCH GEN PSYCHIAT, V66, P95, DOI 10.1001/archgenpsychiatry.2008.519
   Gaetani S, 2008, Eat Weight Disord, V13, pe42
   GALIEGUE S, 1995, EUR J BIOCHEM, V232, P54, DOI 10.1111/j.1432-1033.1995.tb20780.x
   Galve-Roperh I, 2008, CURR PHARM DESIGN, V14, P2279, DOI 10.2174/138161208785740117
   García-Gutiérrez MS, 2010, BRIT J PHARMACOL, V160, P1773, DOI 10.1111/j.1476-5381.2010.00819.x
   Garcia-Gutierrez M. S., 2011, BRIT J PHARMACOL, DOI [10.1111/j.1476-5381.2011.01625.x, DOI 10.1111/J.1476-5381.2011.01625.X.]
   García-Gutiérrez MS, 2011, J PSYCHOPHARMACOL, V25, P111, DOI 10.1177/0269881110379507
   García-Gutiérrez MS, 2010, J PSYCHOPHARMACOL, V24, P757, DOI 10.1177/0269881109106910
   Giuffrida A, 2004, NEUROPSYCHOPHARMACOL, V29, P2108, DOI 10.1038/sj.npp.1300558
   Glass M, 1997, NEUROSCIENCE, V77, P299, DOI 10.1016/S0306-4522(96)00428-9
   Gomes FV, 2011, PSYCHOPHARMACOLOGY, V213, P465, DOI 10.1007/s00213-010-2036-z
   Gong JP, 2006, BRAIN RES, V1071, P10, DOI 10.1016/j.brainres.2005.11.035
   Gorzalka BB, 2011, PROG NEURO-PSYCHOPH, V35, P1575, DOI 10.1016/j.pnpbp.2010.11.021
   Grayson B, 2007, BEHAV BRAIN RES, V184, P31, DOI 10.1016/j.bbr.2007.06.012
   Griffin G, 1999, EUR J PHARMACOL, V377, P117, DOI 10.1016/S0014-2999(99)00402-1
   GROSS H, 1983, J CLIN PSYCHOPHARM, V3, P165
   Gualtieri CT, 2008, J CLIN PSYCHIAT, V69, P1122, DOI 10.4088/JCP.v69n0712
   GUIMARAES FS, 1990, PSYCHOPHARMACOLOGY, V100, P558, DOI 10.1007/BF02244012
   GUIMARAES FS, 1993, BEHAV BRAIN RES, V58, P133, DOI 10.1016/0166-4328(93)90098-B
   GUIMARAES FS, 1994, GEN PHARMACOL, V25, P161, DOI 10.1016/0306-3623(94)90027-2
   Guimaraes VMC, 2004, LIFE SCI, V75, P633, DOI [10.1016/S0024-3205(04)00291-7, 10.1016/j.lfs.2004.01.015]
   Guindon J, 2009, CNS NEUROL DISORD-DR, V8, P403, DOI 10.2174/187152709789824660
   Gururajan A, 2011, BEHAV BRAIN RES, V222, P299, DOI 10.1016/j.bbr.2011.03.053
   Guzmán M, 2001, J MOL MED-JMM, V78, P613, DOI 10.1007/s001090000177
   Hall W, 2009, LANCET, V374, P1383, DOI 10.1016/S0140-6736(09)61037-0
   Haller J, 2007, EUR J NEUROSCI, V25, P2445, DOI 10.1111/j.1460-9568.2007.05476.x
   Haller J, 2005, BEHAV PHARMACOL, V16, P415, DOI 10.1097/00008877-200509000-00014
   Haller J, 2004, EUR J NEUROSCI, V19, P1906, DOI 10.1111/j.1460-9568.2004.03293.x
   Haller J, 2002, EUR J NEUROSCI, V16, P1395, DOI 10.1046/j.1460-9568.2002.02192.x
   Hamdani N, 2008, EUR NEUROPSYCHOPHARM, V18, P34, DOI 10.1016/j.euroneuro.2007.05.005
   Harkany T, 2007, TRENDS PHARMACOL SCI, V28, P83, DOI 10.1016/j.tips.2006.12.004
   Heim C, 2000, PSYCHONEUROENDOCRINO, V25, P1, DOI 10.1016/S0306-4530(99)00035-9
   HERKENHAM M, 1991, J NEUROSCI, V11, P563, DOI 10.1523/jneurosci.11-02-00563.1991
   Hill MN, 2008, J NEUROCHEM, V106, P2322, DOI 10.1111/j.1471-4159.2008.05567.x
   Hill MN, 2009, PSYCHONEUROENDOCRINO, V34, P1257, DOI 10.1016/j.psyneuen.2009.03.013
   Hill MN, 2005, NEUROPSYCHOPHARMACOL, V30, P508, DOI 10.1038/sj.npp.1300601
   Hollis C, 2008, SCHIZOPHR RES, V105, P216, DOI 10.1016/j.schres.2008.07.010
   Hölter SM, 2005, EUR J PHARMACOL, V510, P69, DOI 10.1016/j.ejphar.2005.01.008
   Holtkamp K, 2006, BIOL PSYCHIAT, V60, P311, DOI 10.1016/j.biopsych.2005.11.001
   Huang EJ, 2001, ANNU REV NEUROSCI, V24, P677, DOI 10.1146/annurev.neuro.24.1.677
   Hungund BL, 2004, MOL PSYCHIATR, V9, P184, DOI 10.1038/sj.mp.4001376
   Hyman SE, 2008, NATURE, V455, P890, DOI 10.1038/nature07454
   Ibrahim MM, 2003, P NATL ACAD SCI USA, V100, P10529, DOI 10.1073/pnas.1834309100
   Isaac CL, 2006, CLIN PSYCHOL REV, V26, P939, DOI 10.1016/j.cpr.2005.12.004
   Ishiguro H, 2010, SYNAPSE, V64, P92, DOI 10.1002/syn.20714
   Ishiguro H, 2010, BIOL PSYCHIAT, V67, P974, DOI 10.1016/j.biopsych.2009.09.024
   Iyer SN, 2008, PSYCHOL MED, V38, P1147, DOI 10.1017/S0033291708003152
   Izzo AA, 2009, TRENDS PHARMACOL SCI, V30, P515, DOI 10.1016/j.tips.2009.07.006
   Jager Gerry, 2008, Curr Drug Abuse Rev, V1, P114
   Joosten M, 2002, EXP HEMATOL, V30, P142, DOI 10.1016/S0301-472X(01)00779-2
   Juhasz G, 2009, NEUROPSYCHOPHARMACOL, V34, P2019, DOI 10.1038/npp.2009.19
   Kamprath K, 2009, GENES BRAIN BEHAV, V8, P203, DOI 10.1111/j.1601-183X.2008.00463.x
   Kamprath K, 2006, J NEUROSCI, V26, P6677, DOI 10.1523/JNEUROSCI.0153-06.2006
   Katona I, 2001, J NEUROSCI, V21, P9506, DOI 10.1523/JNEUROSCI.21-23-09506.2001
   Katona I, 1999, J NEUROSCI, V19, P4544
   Katona I, 2008, NAT MED, V14, P923, DOI 10.1038/nm.f.1869
   Kawamura Y, 2006, J NEUROSCI, V26, P2991, DOI 10.1523/JNEUROSCI.4872-05.2006
   Kaye W, 2008, PHYSIOL BEHAV, V94, P121, DOI 10.1016/j.physbeh.2007.11.037
   Kaye WH, 2001, BIOL PSYCHIAT, V49, P644, DOI 10.1016/S0006-3223(00)01013-1
   Kessler RC, 2005, NEW ENGL J MED, V352, P2515, DOI 10.1056/NEJMsa043266
   Kirkham TC, 2002, BRIT J PHARMACOL, V136, P550, DOI 10.1038/sj.bjp.0704767
   Klump KL, 2001, PSYCHOL MED, V31, P737, DOI 10.1017/S0033291701003725
   Koethe D, 2007, J NEURAL TRANSM, V114, P1055, DOI 10.1007/s00702-007-0660-5
   Ledent C, 1999, SCIENCE, V283, P401, DOI 10.1126/science.283.5400.401
   Lemos JI, 2010, BEHAV BRAIN RES, V207, P105, DOI 10.1016/j.bbr.2009.09.045
   Levens SM, 2009, DEPRESS ANXIETY, V26, P403, DOI 10.1002/da.20565
   Leweke FM, 2008, ADDICT BIOL, V13, P264, DOI 10.1111/j.1369-1600.2008.00106.x
   Leweke FM, 2011, INT J NEUROPSYCHOPH, V14, P43, DOI 10.1017/S1461145710000842
   Lewis DA, 2002, ANNU REV NEUROSCI, V25, P409, DOI 10.1146/annurev.neuro.25.112701.142754
   Liu QR, 2009, GENES BRAIN BEHAV, V8, P519, DOI 10.1111/j.1601-183X.2009.00498.x
   Llorente R, 2011, J NEUROENDOCRINOL, V23, P329, DOI 10.1111/j.1365-2826.2011.02109.x
   Llorente-Berzal A., 2011, NEUROPHARMACOLOGY
   Long LE, 2006, NEUROPSYCHOPHARMACOL, V31, P795, DOI 10.1038/sj.npp.1300838
   Löw K, 2000, SCIENCE, V290, P131, DOI 10.1126/science.290.5489.131
   Löwe B, 2001, PSYCHOL MED, V31, P881, DOI 10.1017/S003329170100407X
   Lutz B., 2010, FENS FOR 2010 AMST N
   Lutz B, 2007, MOL NEUROBIOL, V36, P92, DOI 10.1007/s12035-007-8004-x
   Maccarrone M, 2002, EUR J NEUROSCI, V15, P1178, DOI 10.1046/j.1460-9568.2002.01957.x
   Maccarrone M, 2010, ANNU REV NUTR, V30, P423, DOI 10.1146/annurev.nutr.012809.104701
   Mackie K, 2005, HANDB EXP PHARMACOL, V168, P299
   Mahler SV, 2007, NEUROPSYCHOPHARMACOL, V32, P2267, DOI 10.1038/sj.npp.1301376
   MAILLEUX P, 1992, NEUROSCIENCE, V48, P655, DOI 10.1016/0306-4522(92)90409-U
   Maldonado R, 2006, TRENDS NEUROSCI, V29, P225, DOI 10.1016/j.tins.2006.01.008
   Malone DT, 2008, NEUROSCIENCE, V152, P265, DOI 10.1016/j.neuroscience.2007.10.043
   Manji HK, 2001, NAT MED, V7, P541, DOI 10.1038/87865
   Manzanares J, 2004, NEUROTOX RES, V6, P213, DOI 10.1007/BF03033223
   Marco EM, 2009, MINI-REV MED CHEM, V9, P1407, DOI 10.2174/138955709789957468
   Marco EM, 2004, BEHAV PHARMACOL, V15, P21, DOI 10.1097/00008877-200402000-00003
   Marco EM, 2009, NEUROSCI BIOBEHAV R, V33, P498, DOI 10.1016/j.neubiorev.2008.03.008
   Marín S, 2003, PHARMACOL BIOCHEM BE, V74, P649, DOI 10.1016/S0091-3057(02)01041-9
   Marsch R, 2007, J NEUROSCI, V27, P832, DOI 10.1523/JNEUROSCI.3303-06.2007
   Marsicano G, 2006, J Endocrinol Invest, V29, P27
   Marsicano G, 2002, NATURE, V418, P530, DOI 10.1038/nature00839
   Martin M, 2002, PSYCHOPHARMACOLOGY, V159, P379, DOI 10.1007/s00213-001-0946-5
   Matias I, 2007, TRENDS ENDOCRIN MET, V18, P27, DOI 10.1016/j.tem.2006.11.006
   Mechoulam R, 2007, CHEM BIODIVERS, V4, P1678, DOI 10.1002/cbdv.200790147
   Mishima Kenichi, 2005, Stroke, V36, P1077
   Molina-Holgado E, 2002, J NEUROSCI, V22, P9742, DOI 10.1523/jneurosci.22-22-09742.2002
   Monory K, 2006, NEURON, V51, P455, DOI 10.1016/j.neuron.2006.07.006
   Monteleone P, 2005, NEUROPSYCHOPHARMACOL, V30, P1216, DOI 10.1038/sj.npp.1300695
   Monteleone P, 2004, CNS SPECTRUMS, V9, P523, DOI 10.1017/S1092852900009615
   Monteleone P, 2009, GENES BRAIN BEHAV, V8, P728, DOI 10.1111/j.1601-183X.2009.00518.x
   Monteleone P, 2008, PSYCHONEUROENDOCRINO, V33, P546, DOI 10.1016/j.psyneuen.2008.01.004
   Moore THM, 2007, LANCET, V370, P319, DOI 10.1016/S0140-6736(07)61162-3
   Moreira FA, 2009, NEURAL PLAST, V2009, DOI 10.1155/2009/625469
   Moreira FA, 2005, EUR J PHARMACOL, V512, P199, DOI 10.1016/j.ejphar.2005.02.040
   Moreira FA, 2008, ADDICT BIOL, V13, P196, DOI 10.1111/j.1369-1600.2008.00104.x
   Moreira FA, 2006, PROG NEURO-PSYCHOPH, V30, P1466, DOI 10.1016/j.pnpbp.2006.06.004
   Moreira FA, 2010, CURR TOP BEHAV NEURO, V2, P429, DOI 10.1007/7854_2009_16
   Moreira FA, 2007, NEUROPHARMACOLOGY, V52, P958, DOI 10.1016/j.neuropharm.2006.10.013
   Morgan CJA, 2008, BRIT J PSYCHIAT, V192, P306, DOI 10.1192/bjp.bp.107.046649
   Morgan NH, 2009, NEUROPHARMACOLOGY, V57, P356, DOI 10.1016/j.neuropharm.2009.07.017
   Muller Timo Dirk, 2008, Child Adolesc Psychiatry Ment Health, V2, P33, DOI 10.1186/1753-2000-2-33
   Muller-Vahl Kirsten R, 2008, Expert Rev Neurother, V8, P1037, DOI 10.1586/14737175.8.7.1037
   MUNRO S, 1993, NATURE, V365, P61, DOI 10.1038/365061a0
   NARUSE T, 1991, FUNDAM CLIN PHARM, V5, P677, DOI 10.1111/j.1472-8206.1991.tb00757.x
   Navarro M, 1997, NEUROREPORT, V8, P491, DOI 10.1097/00001756-199701200-00023
   Nelson K, 1994, J Palliat Care, V10, P14
   Nestler EJ, 2002, NEURON, V34, P13, DOI 10.1016/S0896-6273(02)00653-0
   Newell KA, 2006, EXP BRAIN RES, V172, P556, DOI 10.1007/s00221-006-0503-x
   O'Sullivan SE, 2010, IMMUNOBIOLOGY, V215, P611, DOI 10.1016/j.imbio.2009.09.007
   Onaivi ES, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001640
   Onaivi ES, 2006, NEUROPSYCHOBIOLOGY, V54, P231, DOI 10.1159/000100778
   Onaivi ES, 2006, ANN NY ACAD SCI, V1074, P514, DOI 10.1196/annals.1369.052
   Onaivi ES, 2008, ANN NY ACAD SCI, V1139, P434, DOI 10.1196/annals.1432.036
   ONAIVI ES, 1990, J PHARMACOL EXP THER, V253, P1002
   Ortega-Alvaro A, 2011, NEUROPSYCHOPHARMACOL, V36, P1489, DOI 10.1038/npp.2011.34
   Pacher P, 2006, PHARMACOL REV, V58, P389, DOI 10.1124/pr.58.3.2
   Pagotto U, 2006, ENDOCR REV, V27, P73, DOI 10.1210/er.2005-0009
   Pamplona F. A., 2011, J PSYCHOPHARMACOL
   Parolaro D, 2010, EXP NEUROL, V224, P3, DOI 10.1016/j.expneurol.2010.03.018
   Peralta V, 2010, MOVEMENT DISORD, V25, P1068, DOI 10.1002/mds.23050
   Pertwee RG, 2008, BRIT J PHARMACOL, V153, P199, DOI 10.1038/sj.bjp.0707442
   Petitet F, 1998, LIFE SCI, V63, pPL1, DOI 10.1016/S0024-3205(98)00238-0
   Piomelli D, 2006, CNS DRUG REV, V12, P21, DOI 10.1111/j.1527-3458.2006.00021.x
   Racz I, 2008, J NEUROSCI, V28, P12125, DOI 10.1523/JNEUROSCI.3400-08.2008
   Racz I, 2008, J NEUROSCI, V28, P12136, DOI 10.1523/JNEUROSCI.3402-08.2008
   Rapoport JL, 2005, MOL PSYCHIATR, V10, P434, DOI 10.1038/sj.mp.4001642
   Reibaud M, 1999, EUR J PHARMACOL, V379, pR1, DOI 10.1016/S0014-2999(99)00496-3
   Reich CG, 2009, BEHAV BRAIN RES, V203, P264, DOI 10.1016/j.bbr.2009.05.013
   Resstel LBM, 2006, BEHAV BRAIN RES, V172, P294, DOI 10.1016/j.bbr.2006.05.016
   Resstel LBM, 2009, BRIT J PHARMACOL, V156, P181, DOI 10.1111/j.1476-5381.2008.00046.x
   Robinson SA, 2010, BRAIN RES, V1343, P153, DOI 10.1016/j.brainres.2010.04.031
   Roche R, 2006, HISTOCHEM CELL BIOL, V126, P177, DOI 10.1007/s00418-005-0127-4
   Rodgers RJ, 2003, EUR J NEUROSCI, V17, P1279, DOI 10.1046/j.1460-9568.2003.02548.x
   Rodriguez-Gaztelumendi A, 2009, J NEUROCHEM, V108, P1423, DOI 10.1111/j.1471-4159.2009.05898.x
   Rosenstock J, 2008, DIABETES CARE, V31, P2169, DOI 10.2337/dc08-0386
   Ross CA, 2006, NEURON, V52, P139, DOI 10.1016/j.neuron.2006.09.015
   Rubin DC, 2008, PSYCHOL REV, V115, P985, DOI 10.1037/a0013397
   Russo EB, 2005, NEUROCHEM RES, V30, P1037, DOI 10.1007/s11064-005-6978-1
   Sánchez C, 1998, FEBS LETT, V436, P6, DOI 10.1016/S0014-5793(98)01085-0
   Sanchis-Segura C, 2004, PSYCHOPHARMACOLOGY, V176, P223, DOI 10.1007/s00213-004-1877-8
   Schatz AR, 1997, TOXICOL APPL PHARM, V142, P278, DOI 10.1006/taap.1996.8034
   Scheen AJ, 2008, J NEUROENDOCRINOL, V20, P139, DOI 10.1111/j.1365-2826.2008.01681.x
   Schneider M, 2005, BEHAV PHARMACOL, V16, P447, DOI 10.1097/00008877-200509000-00018
   Schneider M, 2008, ADDICT BIOL, V13, P253, DOI 10.1111/j.1369-1600.2008.00110.x
   Sciolino NR, 2010, NEUROSCIENCE, V168, P371, DOI 10.1016/j.neuroscience.2010.04.007
   Seifert J, 2007, NEUROSCI LETT, V426, P29, DOI 10.1016/j.neulet.2007.08.008
   Sheline YI, 2000, BIOL PSYCHIAT, V48, P791, DOI 10.1016/S0006-3223(00)00994-X
   Shin LM, 2010, NEUROPSYCHOPHARMACOL, V35, P169, DOI 10.1038/npp.2009.83
   Siegfried Z, 2004, AM J MED GENET B, V125B, P126, DOI 10.1002/ajmg.b.20089
   SILVEIRA NG, 1981, RES COMMUN PSYCH PSY, V6, P251
   Soares VD, 2010, BEHAV BRAIN RES, V213, P225, DOI 10.1016/j.bbr.2010.05.004
   Solowij N, 2007, J PSYCHIATR NEUROSCI, V32, P30
   Solowij Nadia, 2008, Curr Drug Abuse Rev, V1, P81
   Starowicz K, 2007, PHARMACOL THERAPEUT, V114, P13, DOI 10.1016/j.pharmthera.2007.01.005
   Steffens S, 2005, NATURE, V434, P782, DOI 10.1038/nature03389
   Steiner MA, 2008, PHARMACOGENOMICS J, V8, P196, DOI 10.1038/sj.tpj.6500466
   Stoving RK, 2009, J PSYCHIATR RES, V43, P671, DOI 10.1016/j.jpsychires.2008.09.007
   STROBER M, 1995, J AM ACAD CHILD PSY, V34, P724, DOI 10.1097/00004583-199506000-00012
   Suárez J, 2009, HIPPOCAMPUS, V19, P623, DOI 10.1002/hipo.20537
   Substance Abuse and Mental Health Services Administration SAMHSA, 2006, NSDUH SER H
   Sugranyes G, 2009, EUR PSYCHIAT, V24, P282, DOI 10.1016/j.eurpsy.2009.01.002
   Sundram S, 2006, HUM PSYCHOPHARM CLIN, V21, P245, DOI 10.1002/hup.762
   Terzian ALB, 2009, EUR NEUROPSYCHOPHARM, V19, P188, DOI 10.1016/j.euroneuro.2008.11.004
   Thomas A, 2007, BRIT J PHARMACOL, V150, P613, DOI 10.1038/sj.bjp.0707133
   Thomas A, 2009, PSYCHOPHARMACOLOGY, V204, P361, DOI 10.1007/s00213-009-1466-y
   Thomas BF, 1998, J PHARMACOL EXP THER, V285, P285
   Tsai SJ, 2000, PSYCHIATR GENET, V10, P149, DOI 10.1097/00041444-200010030-00008
   Tyrka AR, 2008, BIOL PSYCHIAT, V63, P1147, DOI 10.1016/j.biopsych.2008.01.011
   Ueda N, 2011, BIOFACTORS, V37, P1, DOI 10.1002/biof.131
   Ujike H, 2004, J PHARMACOL SCI, V96, P376, DOI 10.1254/jphs.FMJ04003X4
   Urigüen L, 2011, J PSYCHOPHARMACOL, V25, P105, DOI 10.1177/0269881109358204
   Urigüen L, 2004, NEUROPHARMACOLOGY, V46, P966, DOI 10.1016/j.neuropharm.2004.01.003
   Urigüen L, 2009, PSYCHOPHARMACOLOGY, V206, P313, DOI 10.1007/s00213-009-1608-2
   Valenzano KJ, 2005, NEUROPHARMACOLOGY, V48, P658, DOI 10.1016/j.neuropharm.2004.12.008
   Van Gaal L, 2008, DIABETES CARE, V31, pS229, DOI 10.2337/dc08-s258
   Van Sickle MD, 2005, SCIENCE, V310, P329, DOI 10.1126/science.1115740
   Verty ANA, 2011, NEUROPSYCHOPHARMACOL, V36, P1349, DOI 10.1038/npp.2011.19
   Vigano D, 2009, INT J NEUROPSYCHOPH, V12, P599, DOI 10.1017/S1461145708009371
   Vinod KY, 2006, TRENDS PHARMACOL SCI, V27, P539, DOI 10.1016/j.tips.2006.08.006
   Viveros Maria-Paz, 2007, Neural Plasticity, V2007, DOI 10.1155/2007/52908
   Viveros MP, 2005, PHARMACOL BIOCHEM BE, V81, P331, DOI 10.1016/j.pbb.2005.01.029
   Volkow ND, 2005, NAT NEUROSCI, V8, P555, DOI 10.1038/nn1452
   Waksman Y, 1999, J PHARMACOL EXP THER, V288, P1357
   Walker A., 1994, THESAURUS PSYCHOL IN
   Walsh BT, 2006, JAMA-J AM MED ASSOC, V295, P2605, DOI 10.1001/jama.295.22.2605
   Walter L, 2003, J NEUROSCI, V23, P1398, DOI 10.1523/JNEUROSCI.23-04-01398.2003
   Wegener N, 2009, BRAIN RES, V1253, P81, DOI 10.1016/j.brainres.2008.11.081
   Witkin J. M., 2008, CURR PROTOC NEUROSCI, V45, P9301
   Wolf SA, 2010, CELL COMMUN SIGNAL, V8, DOI 10.1186/1478-811X-8-12
   Wotjak CT, 2005, MINI-REV MED CHEM, V5, P659, DOI 10.2174/1389557054368763
   Xing JH, 2007, J NEUROPHYSIOL, V97, P503, DOI 10.1152/jn.01023.2006
   Yilmazer-Hanke DM, 2008, BEHAV PHARMACOL, V19, P403, DOI 10.1097/FBP.0b013e32830dc0de
   Yu H, 2011, ACTA PHARMACOL SIN, V32, P3, DOI 10.1038/aps.2010.184
   Zamberletti E., 2010, INT J NEUROPSYCHOPH, P1
   Zanelati TV, 2010, BRIT J PHARMACOL, V159, P122, DOI 10.1111/j.1476-5381.2009.00521.x
   Zavitsanou K, 2004, PROG NEURO-PSYCHOPH, V28, P355, DOI 10.1016/j.pnpbp.2003.11.005
   Zuardi AW, 2009, J PSYCHOPHARMACOL, V23, P979, DOI 10.1177/0269881108096519
   Zuardi AW, 2008, REV BRAS PSIQUIATR, V30, P271, DOI 10.1590/S1516-44462008000300015
   Zuardi AW, 2006, J PSYCHOPHARMACOL, V20, P683, DOI 10.1177/0269881106060967
   ZUARDI AW, 1993, BRAZ J MED BIOL RES, V26, P213
   Zuardi AW, 2006, BRAZ J MED BIOL RES, V39, P421, DOI 10.1590/S0100-879X2006000400001
   ZUARDI AW, 1993, J PSYCHOPHARMACOL, V7, P82, DOI 10.1177/026988119300700112
   ZUARDI AW, 1991, PSYCHOPHARMACOLOGY, V104, P260, DOI 10.1007/BF02244189
   ZUARDI AW, 1982, PSYCHOPHARMACOLOGY, V76, P245, DOI 10.1007/BF00432554
   ZUARDI AW, 1995, J CLIN PSYCHIAT, V56, P485
   ZUARDI AW, 1983, ARQ BIOL TECNOL, V26, P391
NR 291
TC 102
Z9 111
U1 1
U2 33
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1662-5153
J9 FRONT BEHAV NEUROSCI
JI Front. Behav. Neurosci.
PD OCT 5
PY 2011
VL 5
AR 63
DI 10.3389/fnbeh.2011.00063
PG 23
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA 844CU
UT WOS:000296726100001
PM 22007164
OA Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Tu, CY
   Chiu, MR
   Wang, YW
   Hsu, CY
   Chen, YY
   Chang, SS
AF Tu, Chao-Ying
   Chiu, Meng-Rou
   Wang, Yi-Wen
   Hsu, Chia-Yueh
   Chen, Ying-Yeh
   Chang, Shu-Sen
TI Association of Body Mass Index and Cardiometabolic Factors With Elderly
   Suicide: A Cohort Study of 101,518 Older Taiwanese
SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Article
DE Body mass index; cardiometabolic risk factors; older people; suicide
ID METABOLIC SYNDROME; RISK-FACTORS; CARDIOVASCULAR-DISEASE; COMPLETED
   SUICIDE; SOCIAL-ISOLATION; UNITED-STATES; HEART-RATE; MORTALITY; HEALTH;
   DEPRESSION
AB Background: Older people have the highest suicide rate across age groups in most countries. The prevalence of cardiometabolic risk factors also increases with age. We investigated the association between body mass index (BMI), cardiometabolic risk factors, and suicide in a large cohort of older people in Taiwan.Methods: We conducted a cohort study using data from an elderly health examination program in Taipei City, Taiwan (2005-2010), linked to the national cause-of-death data files. We used competing risk Cox regression models to investigate the associations of BMI (kg/m(2)) and cardiometabolic factors with suicide after adjusting for sex, age, socioeconomic variables, chronic diseases, psychological distress, and cognitive function.Results: Among 101,518 individuals aged >= 65 years, 92 died by suicide during an average follow-up of 3.9 years. Underweight (BMI<18.5) was associated with increased suicide risk (adjusted hazard ratio [aHR]=2.33, 95% confidence interval [CI] 1.20-4.52) (reference: normal weight). Low diastolic blood pressure was associated with increased suicide risk - aHR was 0.51 (95% CI 0.29-0.91) and 0.55 (95% CI 0.31-0.99) for the third and fourth quartiles of diastolic blood pressure (reference: the lowest quartile), respectively. Older people with a higher waist circumference (aHR per 1-standard-deviation increase=0.60 [95% CI 0.37-0.98]) and a higher number of metabolic syndrome criteria (aHR per 1-criterion increase=0.65 [95% 0.46-0.92]) had lower suicide risk. Systolic blood pressure, pulse rate, fasting blood glucose, and lipid profiles were not associated with suicide risk.Conclusions: Underweight, low diastolic blood pressure, and low waist circumference may be markers of increased suicide risk in older people.
C1 [Tu, Chao-Ying] Natl Taiwan Univ Hosp, Dept Psychiat, Yunlin Branch, Touliu, Yunlin County, Taiwan.
   [Tu, Chao-Ying] Natl Taiwan Univ, Coll Med, Dept Psychiat, Taipei City, Taiwan.
   [Tu, Chao-Ying] Natl Taiwan Univ, Inst Hlth Policy & Management, Coll Publ Hlth, Taipei City, Taiwan.
   [Chiu, Meng-Rou] Yonghe Cardinal Tien Hosp, Dept Occupat Therapy, New Taipei City, Taiwan.
   [Chiu, Meng-Rou; Chang, Shu-Sen] Natl Taiwan Univ, Inst Hlth Behav & Community Sci, Coll Publ Hlth, Room 623, 17,Xu Zhou Rd, Taipei City 10055, Taiwan.
   [Wang, Yi-Wen; Hsu, Chia-Yueh] Taipei Med Univ, Coll Med, Sch Med, Dept Psychiat, Taipei City, Taiwan.
   [Hsu, Chia-Yueh] Taipei Med Univ, Wan Fang Hosp, Dept Psychiat, Taipei City, Taiwan.
   [Hsu, Chia-Yueh; Chang, Shu-Sen] Taipei Med Univ, Wan Fang Hosp, Psychiat Res Ctr, Taipei City, Taiwan.
   [Chen, Ying-Yeh] Taipei City Hosp, Taipei City Psychiat Ctr, Taipei City, Taiwan.
   [Chen, Ying-Yeh] Natl Yang Ming Chiao Tung Univ, Inst Publ Hlth, Taipei City, Taiwan.
   [Chen, Ying-Yeh] Natl Yang Ming Chiao Tung Univ, Dept Publ Hlth, Taipei City, Taiwan.
C3 National Taiwan University; National Taiwan University Hospital;
   National Taiwan University; National Taiwan University; National Taiwan
   University; Taipei Municipal WanFang Hospital; Taipei Municipal WanFang
   Hospital; Taipei City Hospital
RP Chang, SS (corresponding author), Natl Taiwan Univ, Inst Hlth Behav & Community Sci, Coll Publ Hlth, Room 623, 17,Xu Zhou Rd, Taipei City 10055, Taiwan.
EM shusenchang@ntu.edu.tw
RI Chen, Ying-Yeh/AAY-1478-2021; Chang, Shu-Sen/AAH-6733-2021; cheng,
   chien-yu/M-1108-2019
FU Taiwan National Council of Science and Technol-ogy [NSTC
   111-2314-B-002-290]; National Taiwan University Hospital Yunlin Branch
   [112-F003]
FX The study was not funded. Chia-Yueh Hsu was supported by grants from the
   Taiwan National Council of Science and Technology (grant MOST
   110-2628-B-038-016- and NSTC 111-2628-B-038-026) and Wan Fang Hospital
   (grant 111-wf-swf-04 and 112-wf-swf-02) . Shu-Sen Chang was supported by
   a grant from the Taiwan National Council of Science and Technology
   (grant MOST 109-2314-B-002-144-MY3) . Chao-Ying Tu was supported by
   grantsfrom the Taiwan National Council of Science and Technology (grant
   number NSTC 111-2314-B-002-290) and National Taiwan University Hospital
   Yunlin Branch (grant number 112-F003) .r from the Taiwan National
   Council of Science and Technol-ogy (grant number NSTC
   111-2314-B-002-290) and National Taiwan University Hospital Yunlin
   Branch (grant number 112-F003) .
CR Amiri S, 2018, J AFFECT DISORDERS, V238, P615, DOI 10.1016/j.jad.2018.05.028
   Batty GD, 2012, J EPIDEMIOL COMMUN H, V66, P650, DOI 10.1136/jech-2011-200464
   Batty GD, 2010, AM J EPIDEMIOL, V172, P890, DOI 10.1093/aje/kwq274
   Beautrais AL, 2002, SUICIDE LIFE-THREAT, V32, P1, DOI 10.1521/suli.32.1.1.22184
   Bickford D, 2021, AGING MENT HEALTH, V25, P439, DOI 10.1080/13607863.2019.1698514
   Chang JC, 2013, PSYCHOSOM MED, V75, P807, DOI 10.1097/PSY.0000000000000014
   Chang SS, 2016, ACTA PSYCHIAT SCAND, V133, P277, DOI 10.1111/acps.12513
   Chang SS, 2012, AM J EPIDEMIOL, V175, P804, DOI 10.1093/aje/kwr386
   Chang SS, 2010, SOC PSYCH PSYCH EPID, V45, P143, DOI 10.1007/s00127-009-0049-x
   Chen HC, 2005, J FORMOS MED ASSOC, V104, P824
   Chen SM, 2019, ACTA NEUROPSYCHIATR, V31, P266, DOI 10.1017/neu.2019.26
   Chiu HFK, 2004, ACTA PSYCHIAT SCAND, V109, P299, DOI 10.1046/j.1600-0447.2003.00263.x
   Conwell Y, 2000, J AM GERIATR SOC, V48, P23, DOI 10.1111/j.1532-5415.2000.tb03024.x
   Courtin E, 2017, HEALTH SOC CARE COMM, V25, P799, DOI 10.1111/hsc.12311
   COX JP, 1992, J HYPERTENS, V10, pS17
   de Mestral C, 2017, CURR CARDIOL REP, V19, DOI 10.1007/s11886-017-0917-z
   Elovainio M, 2009, J AFFECT DISORDERS, V116, P218, DOI 10.1016/j.jad.2008.12.002
   ERKINJUNTTI T, 1987, J AM GERIATR SOC, V35, P412, DOI 10.1111/j.1532-5415.1987.tb04662.x
   Fiedorowicz JG, 2011, J PSYCHOSOM RES, V70, P145, DOI 10.1016/j.jpsychores.2010.07.010
   Fine JP, 1999, J AM STAT ASSOC, V94, P496, DOI 10.2307/2670170
   Golomb BA, 2002, J CLIN EPIDEMIOL, V55, P767, DOI 10.1016/S0895-4356(02)00407-9
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Health Promotion Administration Ministry of Health and Welfare, Adult Body Mass Index Weight Status Category (Chinese)
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Hubbard RE, 2010, J GERONTOL A-BIOL, V65, P377, DOI 10.1093/gerona/glp186
   Hung GCL, 2015, J AFFECT DISORDERS, V172, P165, DOI 10.1016/j.jad.2014.09.037
   Jee SH, 2011, EUR HEART J, V32, P2773, DOI 10.1093/eurheartj/ehr229
   Kawamura KY, 2002, BODY IMAGE: A HANDBOOK OF THEORY, RESEARCH, AND CLINICAL PRACTICE, P243
   Ko JK, 2019, J AFFECT DISORDERS, V249, P319, DOI 10.1016/j.jad.2019.02.049
   Kuo SY, 2011, PSYCHOL MED, V41, P1665, DOI 10.1017/S0033291710002473
   Lemogne C, 2011, PSYCHOSOM MED, V73, P731, DOI 10.1097/PSY.0b013e3182365dc7
   Manfredini R, 2017, J WOMENS HEALTH, V26, P624, DOI 10.1089/jwh.2016.6103
   McCarthy JF, 2014, OBESITY, V22, P269, DOI 10.1002/oby.20422
   Moussavi S, 2007, LANCET, V370, P851, DOI 10.1016/S0140-6736(07)61415-9
   Mukamal KJ, 2009, OBESITY, V17, P1946, DOI 10.1038/oby.2009.122
   Naghavi Mohsen, 2019, BMJ, V364, pl94, DOI 10.1136/bmj.l94
   Pantell M, 2013, AM J PUBLIC HEALTH, V103, P2056, DOI 10.2105/AJPH.2013.301261
   Perera S, 2016, SUICIDE LIFE-THREAT, V46, P697, DOI 10.1111/sltb.12244
   Schneider B, 2014, J AFFECT DISORDERS, V152, P416, DOI 10.1016/j.jad.2013.10.007
   Singh PN, 2001, AM J EPIDEMIOL, V154, P963, DOI 10.1093/aje/154.10.963
   Stevens J, 1998, NEW ENGL J MED, V338, P1, DOI 10.1056/NEJM199801013380101
   Taipei City Government Suicide Prevention Center, Statistical Analyses
   VATTEN LJ, 1995, EPIDEMIOLOGY, V6, P70, DOI 10.1097/00001648-199501000-00014
   WHO (World Health Organization), 2021, Obesity and overweight
   Woolley C, 2019, J NUTR HEALTH AGING, V23, P558, DOI 10.1007/s12603-019-1206-x
   Wu SQ, 2016, J PSYCHIATR NEUROSCI, V41, P56, DOI 10.1503/jpn.150079
   Yazdanyar A, 2009, CLIN GERIATR MED, V25, P563, DOI 10.1016/j.cger.2009.07.007
   Yeh ST, 2020, J AFFECT DISORDERS, V264, P425, DOI 10.1016/j.jad.2019.11.070
NR 48
TC 3
Z9 3
U1 1
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1064-7481
EI 1545-7214
J9 AM J GERIAT PSYCHIAT
JI Am. J. Geriatr. Psychiatr.
PD NOV
PY 2023
VL 31
IS 11
BP 965
EP 977
DI 10.1016/j.jagp.2023.05.002
EA OCT 2023
PG 13
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA Y1BK8
UT WOS:001102688500001
PM 37258341
DA 2025-06-11
ER

PT J
AU Laddu, DR
   Biggs, E
   Kaar, J
   Khadanga, S
   Alman, R
   Arena, R
AF Laddu, Deepika R.
   Biggs, Elisabeth
   Kaar, Jill
   Khadanga, Sherrie
   Alman, Rocio
   Arena, Ross
TI The impact of the COVID-19 pandemic on cardiovascular health behaviors
   and risk factors: A new troubling normal that may be here to stay
SO PROGRESS IN CARDIOVASCULAR DISEASES
LA English
DT Review
DE COVID-19; Cardiovascular disease; Health behaviors
ID UNITED-STATES; MENTAL-HEALTH; ADULTS; DEPRESSION; LOCKDOWN; ANXIETY
AB In March 2020, the Coronavirus disease 2019 (COVID-19) outbreak was officially declared a global pandemic, leading to closure of public facilities, enforced social distancing and stay-at-home mandates to limit exposures and reduce transmission rates. While the severity of this "lockdown" period varied by country, the disruptions of the pandemic on multiple facets of life (e.g., daily activities, education, the workplace) as well as the social, eco-nomic, and healthcare systems impacts were unprecedented. These disruptions and impacts are having a pro-found negative effect on multiple facets of behavioral health and psychosocial wellbeing that are inextricably linked to cardiometabolic health and associated with adverse outcomes of COVID-19. For example, adoption of various cardiometabolic risk behavior behaviors observed during the pandemic contributed to irretractable trends in weight gain and poor mental health, raising concerns on the possible long-term consequences of the pandemic on cardiometabolic disease risk, and vulnerabilities to future viral pandemics. The purpose of this re-view is to summarize the direct and indirect effects of the pandemic on cardiometabolic health risk behaviors, particularly related to poor diet quality, physical inactivity and sedentary behaviors, smoking, sleep patterns and mental health. Additional insights into how the pandemic has amplified cardiovascular risk behaviors, par-ticularly in our most vulnerable populations, and the potential implications for the future if these modifiable risk behaviors do not become better controlled, are described.(c) 2022 Elsevier Inc. All rights reserved.
C1 [Laddu, Deepika R.; Arena, Ross] Univ Illinois, Coll Appl Sci, Dept Phys Therapy, Chicago, IL USA.
   [Laddu, Deepika R.; Biggs, Elisabeth; Alman, Rocio; Arena, Ross] Hlth Living Pandem Event Protect HL PIVOT Network, Chicago, IL USA.
   [Kaar, Jill] Univ Colorado Anschutz Med Campus, Sch Med, Dept Pediat, Aurora, CO USA.
   [Khadanga, Sherrie] Univ Vermont, Larner Coll Med, Dept Med, Div Cardiol, Burlington, VT USA.
   [Laddu, Deepika R.] Univ Illinois, Coll Appl Hlth Sci, Dept Phys Therapy, 1919 W Taylor St,M-C 898, Chicago, IL 60612 USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of Colorado System;
   University of Colorado Anschutz Medical Campus; University of Vermont;
   University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital
RP Laddu, DR (corresponding author), Univ Illinois, Coll Appl Hlth Sci, Dept Phys Therapy, 1919 W Taylor St,M-C 898, Chicago, IL 60612 USA.
EM dladdu@uic.edu
RI Kaar, Jill/K-8121-2019; LadduPatel, Deepika/AFK-2371-2022; Arena,
   Ross/A-3141-2008
OI Arena, Ross/0000-0002-6675-1996; Laddu, Deepika/0000-0001-6790-0220
CR Alla F, 2020, CAN J PUBLIC HEALTH, V111, P995, DOI 10.17269/s41997-020-00427-x
   Anderson RM, 2020, LANCET, V395, P931, DOI 10.1016/S0140-6736(20)30567-5
   Androutsos O, 2021, NUTRIENTS, V13, DOI 10.3390/nu13030930
   [Anonymous], 2021, LANCET DIABETES ENDO, V9, P189, DOI 10.1016/S2213-8587(21)00058-9
   [Anonymous], 2022, OBESITY RACE ETHNICI
   Arena R, 2022, PROG CARDIOVASC DIS, V71, P69, DOI 10.1016/j.pcad.2021.11.012
   Arena R, 2022, PROG CARDIOVASC DIS, V73, P56, DOI 10.1016/j.pcad.2021.06.008
   Asare S, 2022, ANN INTERN MED, V175, P141, DOI 10.7326/M21-3350
   Banerjee A, 2021, EUR J PREV CARDIOL, V28, P1599, DOI 10.1093/eurjpc/zwaa155
   Bennett G, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.626432
   Bhaskaran K, 2021, LANCET REG HEALTH-EU, V6, DOI 10.1016/j.lanepe.2021.100109
   Bhoyroo R, 2021, BMC PUBLIC HEALTH, V21, DOI 10.1186/s12889-021-11971-7
   Bhutani S, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020671
   Bommelé J, 2020, TOB INDUC DIS, V18, DOI 10.18332/tid/125580
   Bull FC, 2020, BRIT J SPORT MED, V54, P1451, DOI 10.1136/bjsports-2020-102955
   Cecchetto C, 2021, APPETITE, V160, DOI 10.1016/j.appet.2021.105122
   Cena H, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124255
   Centers for Disease Control and Prevention, 2022, TOB MORT OFF SMOK HL
   Centers for Disease Control and Prevention (CDC), 2022, Risk for COVID-19 infection, hospitalization, and death by race/ethnicity
   Chow N, 2020, MMWR-MORBID MORTAL W, V69, P382, DOI 10.15585/mmwr.mm6913e2
   Clark A, 2020, LANCET GLOB HEALTH, V8, P1003, DOI 10.1016/S2214-109X(20)30264-3
   Collard D, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2020-045482
   Consortium NAQ, 2021, REP IMP COVID 19 PAN
   Cornelius ME, 2022, MMWR-MORBID MORTAL W, V71, P397, DOI 10.15585/mmwr.mm7111a1
   Czeisler MÉ, 2020, MMWR-MORBID MORTAL W, V69, P1049, DOI [10.15585/mmwr.mm6932a1, 10.1101/2020.04.22.20076141v1]
   Deschasaux-Tanguy M, 2021, AM J CLIN NUTR, V113, P924, DOI 10.1093/ajcn/nqaa336
   Navarro-Pérez CF, 2022, EUR J CLIN NUTR, V76, P883, DOI 10.1038/s41430-021-01034-w
   Gaffney A, 2022, ANN AM THORAC SOC, V19, P1065, DOI 10.1513/AnnalsATS.202110-1184RL
   Garg S, 2020, MMWR-MORBID MORTAL W, V69, P458, DOI 10.15585/mmwr.mm6915e3
   Gendall P, 2021, NICOTINE TOB RES, V23, P866, DOI 10.1093/ntr/ntaa257
   Giovenco DP, 2021, INT J DRUG POLICY, V94, DOI 10.1016/j.drugpo.2021.103175
   Gonzalez M, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18052582
   Hall G, 2021, PROG CARDIOVASC DIS, V64, P108, DOI 10.1016/j.pcad.2020.04.005
   Hawes MT, 2022, PSYCHOL MED, V52, P3222, DOI 10.1017/S0033291720005358
   Honce R, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.01071
   Irwin M, 2022, CURR OPIN PEDIATR, V34, P107, DOI 10.1097/MOP.0000000000001097
   Jafri A, 2021, PUBLIC HEALTH NUTR, V24, P1798, DOI 10.1017/S1368980021000987
   Jahrami H, 2021, J CLIN SLEEP MED, V17, P299, DOI 10.5664/jcsm.8930
   Kaffenberger M, 2021, INT J EDUC DEV, V81, DOI 10.1016/j.ijedudev.2020.102326
   Kaiser Family Foundation, 2022, US GOV GLOB NONC DIS
   Kalkhoran SM, 2022, AM J PREV MED, V62, P341, DOI 10.1016/j.amepre.2021.08.018
   Klemperer EM, 2020, NICOTINE TOB RES, V22, P1662, DOI 10.1093/ntr/ntaa072
   Kompaniyets L, 2021, JAMA NETW OPEN, V4, DOI 10.1001/jamanetworkopen.2021.11182
   Laddu R, 2021, PROG CARDIOVASC DIS, V64, P102, DOI 10.1016/j.pcad.2020.04.006
   Lange SJ, 2021, MMWR-MORBID MORTAL W, V70, P1278, DOI 10.15585/mmwr.mm7037a3
   Lefferts EC, 2022, J CLIN MED, V11, DOI 10.3390/jcm11061568
   Lichtenstein AH, 2021, CIRCULATION, V144, pE472, DOI 10.1161/CIR.0000000000001031
   Lin AL, 2021, JAMA NETW OPEN, V4, DOI 10.1001/jamanetworkopen.2021.2536
   Lin QY, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2022.0984
   Matsungo TM, 2020, BMJ NUTR PREV HLTH, V3, P205, DOI 10.1136/bmjnph-2020-000124
   Meherali S, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18073432
   Mohebi R, 2022, J AM COLL CARDIOL, V80, P565, DOI 10.1016/j.jacc.2022.05.033
   Morin CM, 2021, SLEEP MED, V87, P38, DOI 10.1016/j.sleep.2021.07.035
   Moro GL, 2022, NUTRIT BURBANK LOS A
   Nagawa CS, 2023, NICOTINE TOB RES, V25, P203, DOI 10.1093/ntr/ntac033
   Nishiga M, 2020, NAT REV CARDIOL, V17, P543, DOI 10.1038/s41569-020-0413-9
   O'Hearn M, 2021, J AM HEART ASSOC, V10, DOI 10.1161/JAHA.120.019259
   Omang T. A., 2021, JINAV, V2, P25, DOI [10.35877/454RI.jinav261, DOI 10.35877/454RI.JINAV261]
   Otu A, 2020, INT J MENT HEALTH SY, V14, DOI 10.1186/s13033-020-00371-w
   Panchal U, 2023, EUR CHILD ADOLES PSY, V32, P1151, DOI 10.1007/s00787-021-01856-w
   Patel AV, 2018, AM J EPIDEMIOL, V187, P2151, DOI 10.1093/aje/kwy125
   Pellegrini M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12072016
   Piercy KL, 2018, CIRC-CARDIOVASC QUAL, V11, DOI 10.1161/CIRCOUTCOMES.118.005263
   Pietrobelli A, 2022, OBES SCI PRACT, V8, P525, DOI 10.1002/osp4.581
   Pinals D.A., 2020, Crisis services: Meeting needs, saving lives (Technical Brief 1)
   Pool LR, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.117.006027
   Rentsch CT, 2020, PLOS MED, V17, DOI 10.1371/journal.pmed.1003379
   Robinson E, 2021, APPETITE, V156, DOI 10.1016/j.appet.2020.104853
   Ruiz-Roso MB, 2020, Nutrients, P12
   Runacres A, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph182111286
   Salari N, 2020, GLOBALIZATION HEALTH, V16, DOI 10.1186/s12992-020-00589-w
   Sato K, 2021, APPETITE, V165, DOI 10.1016/j.appet.2021.105323
   Selvin E, 2020, DIABETES CARE, V43, P1690, DOI 10.2337/dc20-1295
   Sepúlveda-Loyola W, 2020, J NUTR HEALTH AGING, V24, P938, DOI [10.1007/s12603-020-1500-7, 10.1007/s12603-020-1469-2]
   Shah SMA, 2021, COMMUNITY MENT HLT J, V57, P101, DOI 10.1007/s10597-020-00728-y
   Sommer I, 2015, BMC PUBLIC HEALTH, V15, DOI 10.1186/s12889-015-2227-y
   Stanton R, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17114065
   Tebar WR, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.630586
   Tereshchenko LG, 2022, AM J CARDIOL, V179, P102, DOI 10.1016/j.amjcard.2022.06.023
   Thorp AA, 2011, AM J PREV MED, V41, P207, DOI 10.1016/j.amepre.2011.05.004
   Tison GH, 2020, ANN INTERN MED, V173, P767, DOI 10.7326/M20-2665
   Tsao CW, 2022, CIRCULATION, V145, pE153, DOI 10.1161/CIR.0000000000001052
   Wadhera RK, 2020, JAMA-J AM MED ASSOC, V323, P2192, DOI 10.1001/jama.2020.7197
   Wagner BE, 2021, INT J ENV RES PUB HE, P18
   Wiciak MT, 2022, JMIR FORM RES, V6, DOI 10.2196/38370
   Woolford SJ, 2021, JAMA-J AM MED ASSOC, V326, P1434, DOI 10.1001/jama.2021.15036
   World Health Organization, 2022, WHO reveals leading causes of death and disability worldwide: 2000-2019
   World Health Organization, 2022, WHO report on the global tobacco epidemic, 2021
   World Health Organization, 2022, COR DIS COVID 19
   Xie Y, 2022, NAT MED, V28, P583, DOI 10.1038/s41591-022-01689-3
   Zachary Z, 2020, OBES RES CLIN PRACT, V14, P210, DOI 10.1016/j.orcp.2020.05.004
   Zhou F, 2020, LANCET, V395, P1054, DOI 10.1016/S0140-6736(20)30566-3
NR 92
TC 21
Z9 21
U1 1
U2 9
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0033-0620
EI 1873-1740
J9 PROG CARDIOVASC DIS
JI Prog. Cardiovasc. Dis.
PD JAN-FEB
PY 2023
VL 76
BP 38
EP 43
DI 10.1016/j.pcad.2022.11.017
EA MAR 2023
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA A6OX1
UT WOS:000956306500001
PM 36481209
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Tang, AL
   Ertel, KA
   Keen, R
   Beyer, L
   Eckert, N
   Mita, C
   Pintro, K
   Okuzono, SS
   Yazawa, A
   Slopen, N
AF Tang, Alva
   Ertel, Karen A.
   Keen, Ryan
   Beyer, Logan
   Eckert, Natalie
   Mita, Carol
   Pintro, Kedie
   Okuzono, Sakurako S.
   Yazawa, Aki
   Slopen, Natalie
TI Parent-child separation and cardiometabolic outcomes and risk factors in
   adulthood: A systematic review
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE Cardiovascular disease; Metabolic disease; Metabolic syndrome;
   Parent-child separation; War evacuation; Foster care; Temporary care;
   Parental incarceration; Childhood
ID EARLY-LIFE STRESS; HEALTH OUTCOMES; PSYCHOLOGICAL STRESS; HEART-DISEASE;
   PUBLIC CARE; MIDDLE-AGE; ADOLESCENTS; EXPERIENCES; ASSOCIATION; YOUTH
AB Background: Parent-child separation has been associated with negative mental health across childhood and adulthood, yet little is known about the long-term impacts for cardiovascular health. This systematic review synthesized and evaluated the quality of the literature examining the association between exposures to parent-child separation and cardiometabolic outcomes in adulthood.
   Methods: Following a registered protocol, online databases (Pubmed, PsycInfo, and Web of Science) were searched for relevant studies. Studies were included if they (a) defined the exposure before age 18 as institutionalization, foster care placement, parental incarceration, separation due to parents migrating for economic reasons, or asylum and war; and (b) quantified the association between parent-child separation and cardiometabolic events and diagnoses (e.g., coronary heart disease, diabetes) and risk factors (e.g., body mass index, fat distribution, serum-based metabolic markers, inflammatory markers in adulthood (>= age 18). Studies lacking an unexposed comparison group were excluded. The risk for bias in each study was assessed with a modified Newcastle-Ottawa Scale.
   Results: Of the 1938 studies identified, 13 met our inclusion criteria. Two of the four studies examining associations between parent-child separation and cardiometabolic events and diagnoses found positive associations with coronary heart disease and diabetes. Amongst the 13 studies examining associations with any type of adult cardiometabolic risk factors, eight studies reported at least one positive association. Sub-analyses considering separate reasons for parent-child separation provided clearer insights: War evacuation was associated with hypertension and high blood pressure across four studies from the same cohort; out-of home care experiences largely evidenced null results across five different studies, and two studies on parental incarceration suggested positive associations with elevated inflammation, BMI and blood pressure.
   Conclusions: The connections between parent-child separation and adult cardiometabolic outcomes and risk factors are currently inconsistent. The results may depend on the reason for separation, age of assessment, analytic differences and other psychosocial variables that are often unmeasured in this literature.
C1 [Tang, Alva] Univ Texas Dallas, Dept Psychol, Dallas, TX USA.
   [Ertel, Karen A.; Keen, Ryan; Beyer, Logan; Pintro, Kedie; Okuzono, Sakurako S.; Yazawa, Aki; Slopen, Natalie] Harvard TH Chan Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA USA.
   [Ertel, Karen A.] Univ Massachusetts Amherst, Dept Biostat & Epidemiol, Amherst, MA USA.
   [Beyer, Logan] Harvard Univ, Harvard Med Sch, Cambridge, MA USA.
   [Eckert, Natalie] Tufts Univ, Dept Community Hlth, Medford, MA USA.
   [Mita, Carol] Harvard Med Sch, Countway Lib Med, Boston, MA USA.
   [Yazawa, Aki] Natl Ctr Global Hlth & Med, Ctr Clin Sci, Dept Epidemiol & Prevent, Tokyo, Japan.
   [Slopen, Natalie] Harvard Univ, Ctr Developing Child, Cambridge, MA USA.
   [Tang, Alva] Univ Texas Dallas, Dept Psychol, 800 Campbell Rd, Richardson, TX 75080 USA.
C3 University of Texas System; University of Texas Dallas; Harvard
   University; Harvard T.H. Chan School of Public Health; University of
   Massachusetts System; University of Massachusetts Amherst; Harvard
   University; Tufts University; Harvard University; Harvard Medical
   School; Japan Institute for Health Security (JIHS); National Center for
   Global Health & Medicine - Japan; Harvard University; University of
   Texas System; University of Texas Dallas
RP Tang, AL (corresponding author), Univ Texas Dallas, Dept Psychol, 800 Campbell Rd, Richardson, TX 75080 USA.
EM alvatang@utdallas.edu
RI Shiba, Sakurako/AAT-6687-2021
OI Keen, Ryan/0009-0001-3480-5603
FU National Institute on Aging (NIA) [R24AG065174]; National Institutes of
   Health [1R01HL151848-01]; Japan Society for the Promotion of Science
   Research Fellowship for Young Scientists [JP21J01171]
FX This project was supported by a seed grant from the Reversibility
   Network, a National Institute on Aging (NIA) -funded network of
   re-searchers whose mission is to advance research around remediating the
   effects of early life adversities (ELA) in mid and later life (Grant:
   R24AG065174) . In addition, Drs. Tang and Slopen were supported by the
   National Institutes of Health Grant (1R01HL151848-01) . Dr. Yazawa was
   financially supported by Japan Society for the Promotion of Science
   Research Fellowship for Young Scientists (JP21J01171) .
CR Administration of Children and Families, NAT DAT SHOWS NUMB C
   Ahrens KR, 2014, PEDIATRICS, V134, P1067, DOI 10.1542/peds.2014-1150
   Alastalo H, 2013, J HUM HYPERTENS, V27, P90, DOI 10.1038/jhh.2012.6
   Alastalo H, 2012, PSYCHOSOM MED, V74, P583, DOI 10.1097/PSY.0b013e31825b3d76
   Alastalo H, 2009, ANN MED, V41, P66, DOI 10.1080/07853890802301983
   Almeida ND, 2010, PSYCHOSOM MED, V72, P148, DOI 10.1097/PSY.0b013e3181c925cb
   [Anonymous], Latest UAC Data-FY2024
   Batty GD, 2021, AM J EPIDEMIOL, V190, P176, DOI 10.1093/aje/kwaa079
   Bevan K, 2021, PSYCHONEUROENDOCRINO, V130, DOI 10.1016/j.psyneuen.2021.105253
   Boch SJ, 2015, BIOL RES NURS, V17, P574, DOI 10.1177/1099800414564011
   Brown DW, 2009, AM J PREV MED, V37, P389, DOI 10.1016/j.amepre.2009.06.021
   Chiang JJ, 2022, PSYCHOL BULL, V148, P27, DOI 10.1037/bul0000351
   Cooley ME, 2018, FAM COMMUNITY HEALTH, V41, P159, DOI 10.1097/FCH.0000000000000190
   de Mestral C, 2020, AM J HUM BIOL, V32, DOI 10.1002/ajhb.23343
   Dong MX, 2004, CIRCULATION, V110, P1761, DOI 10.1161/01.CIR.0000143074.54995.7F
   Fellmeth G, 2018, LANCET, V392, P2567, DOI 10.1016/S0140-6736(18)32558-3
   Gotsch K., 2018, Families and mass incarceration
   Hengesch X, 2018, CHILD ABUSE NEGLECT, V85, P137, DOI 10.1016/j.chiabu.2018.04.002
   HOUSE JS, 1990, MILBANK Q, V68, P383, DOI 10.2307/3350111
   Hughes K, 2017, LANCET PUBLIC HEALTH, V2, pE356, DOI 10.1016/S2468-2667(17)30118-4
   Johnson DE, 2018, J PEDIATR-US, V203, P345, DOI 10.1016/j.jpeds.2018.07.027
   Kajeepeta S, 2015, SLEEP MED, V16, P320, DOI 10.1016/j.sleep.2014.12.013
   Koss KJ, 2016, PSYCHONEUROENDOCRINO, V66, P31, DOI 10.1016/j.psyneuen.2015.12.018
   Larkin KT, 2020, CARDIOVASCULAR IMPLICATIONS OF STRESS AND DEPRESSION, P1, DOI 10.1016/B978-0-12-815015-3.00001-5
   Levine GN, 2021, CIRCULATION, V143, pE763, DOI 10.1161/CIR.0000000000000947
   Liu WX, 2021, BRAIN BEHAV IMMUN, V98, P257, DOI 10.1016/j.bbi.2021.08.227
   Loucks EB, 2011, PSYCHOSOM MED, V73, P563, DOI 10.1097/PSY.0b013e318228c820
   McLaughlin KA, 2015, P NATL ACAD SCI USA, V112, P5637, DOI 10.1073/pnas.1423363112
   Miller GE, 2011, PSYCHOL BULL, V137, P959, DOI 10.1037/a0024768
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Racaite J, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18031167
   Reid BM, 2017, PEDIATR RES, V82, P278, DOI 10.1038/pr.2017.35
   Reiss D, 2019, DEV PSYCHOL, V55, P2203, DOI 10.1037/dev0000780
   Robert SA, 2001, RES AGING, V23, P233, DOI 10.1177/0164027501232005
   Roettger ME, 2022, SSM-POPUL HLTH, V18, DOI 10.1016/j.ssmph.2022.101107
   Roettger ME, 2012, AM J EPIDEMIOL, V175, P636, DOI 10.1093/aje/kwr409
   Russell SJ, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2015-007770
   Savolainen K, 2014, BIOL PSYCHOL, V97, P35, DOI 10.1016/j.biopsycho.2014.02.002
   Schapiro NA, 2013, CURR PROB PEDIATR AD, V43, P48, DOI 10.1016/j.cppeds.2012.12.001
   Schneider R, 2009, CHILD YOUTH SERV REV, V31, P440, DOI 10.1016/j.childyouth.2008.09.011
   Seker S, 2022, EUR CHILD ADOLES PSY, V31, P1963, DOI 10.1007/s00787-021-01828-0
   Suarez A, 2018, CLIN EPIGENETICS, V10, DOI 10.1186/s13148-018-0528-6
   Suarez A, 2017, PSYCHOSOM MED, V79, P524, DOI 10.1097/PSY.0000000000000439
   Tang AL, 2020, DEV PSYCHOPATHOL, V32, P1715, DOI 10.1017/S0954579420001479
   Tyrka AR, 2008, BIOL PSYCHIAT, V63, P1147, DOI 10.1016/j.biopsych.2008.01.011
   Waddoups A.B., 2019, ANN REV DEVELOPMENTA, V1, P387, DOI DOI 10.1146/ANNUREV-DEVPSYCH-121318-085142
   Wang Y, 2016, SLEEP MED, V21, P12, DOI 10.1016/j.sleep.2016.01.011
   Wells G., 2014, NEWCASTLE OTTAWA QUA
   World Health Organization, The Top 10 Causes of Death 2018
   Xie T, 2021, J EPIDEMIOL COMMUN H, V75, P289, DOI 10.1136/jech-2020-214737
   Zeanah C.H., 2020, LANCET CHILD ADOLESC
   Zhang DD, 2021, J AFFECT DISORDERS, V278, P320, DOI 10.1016/j.jad.2020.09.030
NR 52
TC 3
Z9 3
U1 2
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JUN
PY 2023
VL 152
AR 106084
DI 10.1016/j.psyneuen.2023.106084
EA MAR 2023
PG 18
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA D4MY2
UT WOS:000968500700001
PM 36996574
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Robinson, E
   Daly, M
   Putra, IGNE
AF Robinson, Eric
   Daly, Michael
   Putra, I. Gusti Ngurah Edi
TI The psychological burden associated with metabolic syndrome: Evidence
   from UK and US older adults
SO OBESITY SCIENCE & PRACTICE
LA English
DT Article
DE metabolic syndrome; non-communicable diseases (NCDs); psychological
   well-being
ID COHORT PROFILE; RISK; METAANALYSIS; DEPRESSION; HEALTH; ANXIETY; OBESE
AB IntroductionWe examined the psychological burden associated with metabolic syndrome (MetSyn).MethodsWe used comparable longitudinal data of older adults (>= 50 years) from the UK (English Longitudinal Study of Aging) and the US (Health and Retirement Study). We defined MetSyn based on biomarker assessments (e.g., blood pressure, impaired glycemic control). Using regression models, we tested a range of individual psychological outcomes (e.g., depressive symptoms) associated with MetSyn. We also examined whether these psychological outcomes may explain or moderate the link between MetSyn and non-communicable diseases (NCDs).FindingsMetSyn was associated cross-sectionally with a range of psychological outcomes, including depression, anxiety, loneliness, hopelessness, cynical hostility, social strain, negative affect and decreased positive affect, social support and purpose in life. There was no convincing evidence that psychological factors interacted with or explained (mediated) the relationship between MetSyn and increased risk of developing NCD over 10-year follow-ups.ConclusionsMetSyn and the psychological burden outcomes examined may have independent effects on NCD risk.
C1 [Robinson, Eric; Putra, I. Gusti Ngurah Edi] Univ Liverpool, Inst Populat Hlth, Dept Psychol, Eleanor Rathbone Bldg,Bedford St South, Liverpool L69 7ZA, England.
   [Daly, Michael] Maynooth Univ, Dept Psychol, Maynooth, Ireland.
C3 University of Liverpool; Maynooth University
RP Putra, IGNE (corresponding author), Univ Liverpool, Inst Populat Hlth, Dept Psychol, Eleanor Rathbone Bldg,Bedford St South, Liverpool L69 7ZA, England.
EM i.gusti.ngurah.edi.putra@liverpool.ac.uk
RI Putra, I Gusti Ngurah Edi/AAG-2836-2020
OI Putra, I Gusti Ngurah Edi/0000-0002-1014-6949; Robinson,
   Eric/0000-0003-3586-5533
FU Economic and Social Research Council [ES/V017594/1]
FX Economic and Social Research Council, Grant/Award Number: ES/V017594/1
CR Capizzi JA, 2010, PHYSICIAN SPORTSMED, V38, P45, DOI 10.3810/psm.2010.04.1761
   Cornier MA, 2008, ENDOCR REV, V29, P777, DOI 10.1210/er.2008-0024
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Emdin CA, 2016, AM J CARDIOL, V118, P511, DOI 10.1016/j.amjcard.2016.05.041
   Goldbacher EM, 2007, ANN BEHAV MED, V34, P240, DOI 10.1007/BF02874549
   Hamer M, 2012, MOL PSYCHIATR, V17, P940, DOI 10.1038/mp.2012.30
   Henriksen RE, 2019, J EPIDEMIOL COMMUN H, V73, P941, DOI 10.1136/jech-2019-212335
   Kuo WC, 2019, OBES REV, V20, P1651, DOI 10.1111/obr.12915
   Nilsson PM, 2019, EUR J PREV CARDIOL, V26, P33, DOI 10.1177/2047487319886404
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Putra IGNE, 2024, INT J OBESITY, V48, P1283, DOI 10.1038/s41366-024-01551-1
   Sarwer DB, 2020, AM PSYCHOL, V75, P252, DOI 10.1037/amp0000550
   Sarwer DB, 2016, ENDOCRIN METAB CLIN, V45, P677, DOI 10.1016/j.ecl.2016.04.016
   Sonnega A, 2014, INT J EPIDEMIOL, V43, P576, DOI 10.1093/ije/dyu067
   St-Onge MP, 2004, DIABETES CARE, V27, P2222, DOI 10.2337/diacare.27.9.2222
   Steptoe A, 2013, INT J EPIDEMIOL, V42, P1640, DOI 10.1093/ije/dys168
   Tang F, 2017, PSYCHONEUROENDOCRINO, V77, P112, DOI 10.1016/j.psyneuen.2016.11.025
   Tindle HA, 2009, CIRCULATION, V120, P656, DOI 10.1161/CIRCULATIONAHA.108.827642
   Tomiyama AJ, 2018, BMC MED, V16, DOI 10.1186/s12916-018-1116-5
   Uhing A, 2021, J BEHAV MED, V44, P673, DOI 10.1007/s10865-021-00221-1
   Van der Kooy K, 2007, INT J GERIATR PSYCH, V22, P613, DOI 10.1002/gps.1723
NR 21
TC 1
Z9 1
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2055-2238
J9 OBES SCI PRACT
JI OBES. SCI. PRACT.
PD AUG
PY 2024
VL 10
IS 4
AR e780
DI 10.1002/osp4.780
PG 9
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA XQ7Y3
UT WOS:001263222600001
PM 38974477
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Reddy, BR
   Maitra, S
   Jhelum, P
   Kumar, KP
   Bagul, PK
   Kaur, G
   Banerjee, SK
   Kumar, A
   Chakravarty, S
AF Reddy, B. Raghunath
   Maitra, Swati
   Jhelum, Priya
   Kumar, K. Praveen
   Bagul, Pankaj K.
   Kaur, Gagandeep
   Banerjee, Sanjay K.
   Kumar, Arvind
   Chakravarty, Sumana
TI Sirtuin 1 and 7 mediate resveratrol-induced recovery from hyper-anxiety
   in high-fructose-fed prediabetic rats
SO JOURNAL OF BIOSCIENCES
LA English
DT Article
DE Epigenetic; fructose; metformin; mood disorders; sirtuins; type 2
   diabetes
ID IMPROVES INSULIN SENSITIVITY; OXIDATIVE STRESS; EPIGENETIC MECHANISMS;
   METABOLIC SYNDROME; METFORMIN; RESISTANCE; BRAIN; PROTECTS; DISEASES;
   ASSAY
AB Hyperglycaemia in diabetes is either caused by reduced availability of insulin (type 1 diabetes, T1D) or insulin resistance to the cells (type 2 diabetes, T2D). In recent years, the prevalence of T2D has increased to an alarming proportion, encompassing 95% of the total diabetic burden, probably due to economy-driven changes in lifestyle. Recent epidemiological studies show comorbid depression, anxiety and related mental illness. To explore the molecular mechanisms underlying this comorbid conditions, we used Sprague-Dawley rats on high-fructose diet for 8 weeks to induce prediabetic condition. Rats with this metabolic syndrome also showed hyper-anxiety when they were subjected to anxiety-related behavioural assays. Rats were administered with resveratrol, an activator of sirtuins, and metformin, a standard antidiabetic drug, simultaneously with fructose. We observed that resveratrol was more effective in protecting from both the metabolic (prediabetic) and affective (anxiety) disorders than metformin. Molecular studies showed that recovery was associated with the upregulation of few nuclear sirtuins that act epigenetically - Sirt 1 and 7, which were significantly attenuated in the striatum of prediabetic rats. In conclusion, our study showed that hyper-anxiety associated with prediabetic condition is ameliorated by resveratrol through modulation of sirtuins, which is more or less similar to metformin.
C1 [Reddy, B. Raghunath; Maitra, Swati; Jhelum, Priya; Kumar, K. Praveen] Indian Inst Chem Technol IICT, Chem Biol, Hyderabad 500007, Andhra Pradesh, India.
   [Bagul, Pankaj K.; Kaur, Gagandeep; Banerjee, Sanjay K.; Chakravarty, Sumana] Indian Inst Chem Technol IICT, Med Chem & Pharmacol, Hyderabad 500007, Andhra Pradesh, India.
   [Kumar, Arvind] Ctr Cellular & Mol Biol CCMB, Uppal Rd, Hyderabad 500007, Andhra Pradesh, India.
   [Bagul, Pankaj K.; Banerjee, Sanjay K.] Translat Hlth Sci & Technol Inst THSTI, Drug Discovery Res Ctr DDRC, Faridabad 121001, Haryana, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Indian Institute of Chemical Technology (IICT); Council of Scientific &
   Industrial Research (CSIR) - India; CSIR - Indian Institute of Chemical
   Technology (IICT); Council of Scientific & Industrial Research (CSIR) -
   India; CSIR - Centre for Cellular & Molecular Biology (CCMB); Department
   of Biotechnology (DBT) India; Translational Health Science & Technology
   Institute (THSTI)
RP Chakravarty, S (corresponding author), Indian Inst Chem Technol IICT, Med Chem & Pharmacol, Hyderabad 500007, Andhra Pradesh, India.
EM sumanachak@iict.res.in
RI Chakravarty, Sumana/AAW-2823-2021; Dr. Pankaj K. Bagul, M.S/I-3867-2012;
   Kumar, Arvind/B-6094-2009; JHELUM, PRIYA/ACY-0028-2022
OI Kumar, Arvind/0000-0003-2879-3826; JHELUM, PRIYA/0000-0003-0779-2816;
   Banerjee, Sanjay/0000-0002-0008-0480; Banerjee, Sanjay
   k/0000-0002-0044-0984
FU Ramalingaswami Re-entry Individual Fellowships; Department of
   Biotechnology, India; Council of Scientific and Industrial Research
   (CSIR) [BSC0103-UNDO]
FX The project was initiated under the Ramalingaswami Re-entry Individual
   Fellowships to SC and SKB by the Department of Biotechnology, India, and
   supported by the Council of Scientific and Industrial Research (CSIR)
   network projects [BSC0103-UNDO to SC, SKB and AK]. SM, PKB and BRR wish
   to thank CSIR for their SRFs. The authors would like to thank Pranav C
   Joshi for the help in preparing the manuscript.
CR Albani D, 2010, BIOFACTORS, V36, P370, DOI 10.1002/biof.118
   Alwan A, 2011, GLOBAL STATUS REPORT ON NONCOMMUNICABLE DISEASES 2010, P9
   Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
   Ates O, 2007, J CLIN NEUROSCI, V14, P256, DOI 10.1016/j.jocn.2005.12.010
   Bagul PK, 2015, CURR MOL MED, V15, P312, DOI 10.2174/1566524015666150505155702
   Bagul PK, 2015, J NUTR BIOCHEM, V26, P1298, DOI 10.1016/j.jnutbio.2015.06.006
   Bagul PK, 2013, CURR PHARM DESIGN, V19, P5663, DOI 10.2174/13816128113199990372
   Bagul PK, 2012, PHARMACOL RES, V66, P260, DOI 10.1016/j.phrs.2012.05.003
   Cade WT, 2008, PHYS THER, V88, P1322, DOI 10.2522/ptj.20080008
   Cantó C, 2009, NATURE, V458, P1056, DOI 10.1038/nature07813
   Chakraborty A, 2011, DIABETES RES CLIN PR, V93, P56, DOI 10.1016/j.diabres.2010.11.030
   Chakravarty S, 2014, INT REV NEUROBIOL, V115, P117, DOI 10.1016/B978-0-12-801311-3.00004-4
   Collins MM, 2009, DIABETIC MED, V26, P153, DOI 10.1111/j.1464-5491.2008.02648.x
   Correia S, 2008, MED CHEM, V4, P358, DOI 10.2174/157340608784872299
   Diamond J, 2011, NATURE, V469, P478, DOI 10.1038/469478a
   Ducat L, 2015, DIABETES CARE, V38, P333, DOI 10.2337/dc14-1383
   Ducat LJ, 2014, JAMA-J AM MED ASSOC, V312, P2413, DOI 10.1001/jama.2014.14778
   Dudley KJ, 2011, NEUROSCI BIOBEHAV R, V35, P1544, DOI 10.1016/j.neubiorev.2010.12.016
   Esteghamati A, 2013, CLIN NUTR, V32, P179, DOI 10.1016/j.clnu.2012.08.006
   Farvid MS, 2014, BRAIN BEHAV IMMUN, V36, P176, DOI 10.1016/j.bbi.2013.10.025
   Gale EAM, 2001, DIABETOLOGIA, V44, P3, DOI 10.1007/s001250051573
   Giacco F, 2010, CIRC RES, V107, P1058, DOI 10.1161/CIRCRESAHA.110.223545
   Griebel G, 1997, PSYCHOPHARMACOLOGY, V131, P180, DOI 10.1007/s002130050282
   Haigis MC, 2006, GENE DEV, V20, P2913, DOI 10.1101/gad.1467506
   Jiang T, 2014, BRIT J PHARMACOL, V171, P3146, DOI 10.1111/bph.12655
   Jiang Y, 2008, J NEUROSCI, V28, P11753, DOI 10.1523/JNEUROSCI.3797-08.2008
   Kesebir S, 2014, WORLD J CLIN CASES, V2, P332, DOI 10.12998/wjcc.v2.i8.332
   Lagouge M, 2006, CELL, V127, P1109, DOI 10.1016/j.cell.2006.11.013
   Li J, 2010, STROKE, V41, P2645, DOI 10.1161/STROKEAHA.110.589697
   Liu YC, 2008, ANAL BIOCHEM, V378, P53, DOI 10.1016/j.ab.2008.02.018
   Liu ZX, 2011, NUCLEIC ACIDS RES, V39, pD1029, DOI 10.1093/nar/gkq939
   Luchsinger JA, 2010, J NEUROL SCI, V299, P35, DOI 10.1016/j.jns.2010.08.063
   Mao ZY, 2011, SCIENCE, V332, P1443, DOI 10.1126/science.1202723
   Maritim AC, 2003, J BIOCHEM MOL TOXIC, V17, P24, DOI 10.1002/jbt.10058
   Mathers CD, 2006, PLOS MED, V3, DOI 10.1371/journal.pmed.0030442
   Mcnay EC, 2011, NEUROBIOL LEARN MEM, V96, P432, DOI 10.1016/j.nlm.2011.08.005
   Miatello R, 2005, AM J HYPERTENS, V18, P864, DOI 10.1016/j.amjhyper.2004.12.012
   Nemoto S, 2005, J BIOL CHEM, V280, P16456, DOI 10.1074/jbc.M501485200
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   Padiya R, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-53
   Pintana H, 2012, LIFE SCI, V91, P409, DOI 10.1016/j.lfs.2012.08.017
   Rodgers JT, 2005, NATURE, V434, P113, DOI 10.1038/nature03354
   Sacharczuk M, 2009, ACTA NEUROBIOL EXP, V69, P459
   Schmatz R, 2009, EUR J PHARMACOL, V610, P42, DOI 10.1016/j.ejphar.2009.03.032
   Sojitra B, 2012, MOL CELL BIOCHEM, V360, P61, DOI 10.1007/s11010-011-1044-6
   Sun C, 2007, CELL METAB, V6, P307, DOI 10.1016/j.cmet.2007.08.014
   Tsankova N, 2007, NAT REV NEUROSCI, V8, P355, DOI 10.1038/nrn2132
   Urdinguio RG, 2009, LANCET NEUROL, V8, P1056, DOI 10.1016/S1474-4422(09)70262-5
   Vakhrusheva O, 2008, CIRC RES, V102, P703, DOI 10.1161/CIRCRESAHA.107.164558
   Volmar CH., 2015, NEUROEPIGENETICS, V1, P20
NR 50
TC 29
Z9 30
U1 0
U2 19
PU INDIAN ACAD SCIENCES
PI BANGALORE
PA C V RAMAN AVENUE, SADASHIVANAGAR, P B #8005, BANGALORE 560 080, INDIA
SN 0250-5991
EI 0973-7138
J9 J BIOSCIENCES
JI J. Biosci.
PD SEP
PY 2016
VL 41
IS 3
BP 407
EP 417
DI 10.1007/s12038-016-9627-8
PG 11
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA DT5HM
UT WOS:000381513000009
PM 27581932
DA 2025-06-11
ER

PT J
AU Minder, CM
   Shaya, GE
   Michos, ED
   Keenan, TE
   Blumenthal, RS
   Nasir, K
   Carvalho, JAM
   Conceiçao, RD
   Santos, RD
   Blaha, MJ
AF Minder, Camille Michael
   Shaya, Gabriel E.
   Michos, Erin D.
   Keenan, Tanya E.
   Blumenthal, Roger S.
   Nasir, Khurram
   Carvalho, Jose A. M.
   Conceicao, Raquel D.
   Santos, Raul D.
   Blaha, Michael J.
TI Relation Between Self-Reported Physical Activity Level, Fitness, and
   Cardiometabolic Risk
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID CARDIORESPIRATORY FITNESS; ACTIVITY QUESTIONNAIRE;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; EXERCISE CAPACITY;
   TREADMILL; VALIDITY; ASSOCIATION; MORTALITY; ADULTS
AB Physical activity and cardiorespiratory fitness are associated with improved cardiovascular health and reduced all-cause mortality. The relation between self-reported physical activity, objective physical fitness, and the association of each with cardiometabolic risk has not been fully described. We studied 2,800 healthy Brazilian subjects referred for an employer-sponsored health screening. Physical activity level was determined as "low," "moderate," or "high" with the International Physical Activity Questionnaire: Short Form (IPAQ-SF). Fitness was measured as METs achieved on a maximal, symptom-limited, treadmill stress test. Using multivariate linear regression analysis, we calculated age, gender, and smoking-adjusted correlation coefficients among IPAQ-SF, fitness, and cardiometabolic risk factors. Mean age of study participants was 43 +/- 9 years; 81% were men, and 43% were highly active. Mean METs achieved was 12 +/- 2. IPAQ-SF category and fitness were moderately correlated (r = 0.377). Compared with IPAQ-SF category, fitness was better correlated with cardiometabolic risk factors including anthropomorphic measurements, blood pressure, fasting blood glucose, dyslipidemia, high-sensitivity C-reactive protein, and hepatic steatosis (all p <0.01). Among these, anthropomorphic measurements, blood pressure, high-sensitivity C-reactive protein, and hepatic steatosis had the largest discrepancies in correlation, whereas lipid factors had the least discrepant correlation. When IPAQ-SF and fitness were discordant, poor fitness drove associations with elevated cardiometabolic risk. In conclusion, self-reported physical activity level and directly measured fitness are moderately correlated, and the latter is more strongly associated with a protective cardiovascular risk profile. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Minder, Camille Michael; Shaya, Gabriel E.; Michos, Erin D.; Keenan, Tanya E.; Blumenthal, Roger S.; Nasir, Khurram; Blaha, Michael J.] Johns Hopkins Ciccarone Ctr Prevent Heart Dis, Baltimore, MD 21287 USA.
   [Shaya, Gabriel E.] Univ Miami, Miller Sch Med, Miami, FL 33136 USA.
   [Keenan, Tanya E.] Massachusetts Gen Hosp, Boston, MA 02114 USA.
   [Nasir, Khurram] Baptist Hlth South Florida, Miami, FL USA.
   [Carvalho, Jose A. M.; Conceicao, Raquel D.; Santos, Raul D.] Hosp Israelita Albert Einstein, Prevent Med Ctr, Sao Paulo, Brazil.
   [Santos, Raul D.] Univ Sao Paulo, Med Sch Hosp, Lipid Clin Heart Inst InCor, Sao Paulo, Brazil.
C3 Johns Hopkins University; Johns Hopkins Medicine; University of Miami;
   Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Hospital Israelita Albert Einstein; Universidade de
   Sao Paulo
RP Blaha, MJ (corresponding author), Johns Hopkins Ciccarone Ctr Prevent Heart Dis, Baltimore, MD 21287 USA.
EM mblaha1@jhmi.edu
RI Nasir, Khurram/A-2317-2008; Santos, Raul/A-1170-2010; Blumenthal,
   Roger/H-3223-2018
OI Keenan, Tanya/0000-0001-5300-9998; Michos, Erin/0000-0002-5547-5084
CR Ahmed HM, 2012, AM J CARDIOL, V109, P288, DOI 10.1016/j.amjcard.2011.08.042
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   American College of Sports Medicine, 2006, ACMS GUID EX TEST PR
   [Anonymous], CLIN GUID ID EV TREA
   [Anonymous], ACSMS MET CALC HDB
   Aronson D, 2004, J AM COLL CARDIOL, V44, P2003, DOI 10.1016/j.jacc.2004.08.030
   Babor TF., 1989, AUDIT ALCOHOL USE DI
   Bellentani S, 2000, ANN INTERN MED, V132, P112, DOI 10.7326/0003-4819-132-2-200001180-00004
   Brown W, 2004, AUST NZ J PUBL HEAL, V28, P128, DOI 10.1111/j.1467-842X.2004.tb00925.x
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   ELLESTAD MH, 1969, CIRCULATION, V39, P517, DOI 10.1161/01.CIR.39.4.517
   Grundy SM, 2012, AM J CARDIOL, V109, P988, DOI 10.1016/j.amjcard.2011.11.031
   Hallal PC, 2010, J PHYS ACT HEALTH, V7, pS259, DOI 10.1123/jpah.7.s2.s259
   International physical activity questionnaire (IPAQ), 2005, Security Guidelines for the Electricity Sector: Physical Response, Version 3.0, P1
   Jellinger Paul S, 2012, Endocr Pract, V18 Suppl 1, P1
   JOSEPH AEA, 1991, CLIN RADIOL, V43, P26, DOI 10.1016/S0009-9260(05)80350-2
   Lee DC, 2011, CIRCULATION, V124, P2483, DOI 10.1161/CIRCULATIONAHA.111.038422
   Lee PH, 2011, INT J BEHAV NUTR PHY, V8, DOI 10.1186/1479-5868-8-115
   McDonough JRBRA, 1969, J S C Med Assoc, V65, P25
   Myers J, 2004, AM J MED, V117, P912, DOI 10.1016/j.amjmed.2004.06.047
   Papathanasiou G, 2010, EUR J CARDIOV PREV R, V17, P380, DOI 10.1097/HJR.0b013e328333ede6
   Peterson PN, 2008, ARCH INTERN MED, V168, P174, DOI 10.1001/archinternmed.2007.68
   POLLOCK ML, 1976, AM HEART J, V92, P39, DOI 10.1016/S0002-8703(76)80401-2
   Sharma S, 2010, J HUM NUTR DIET, V23, P5, DOI 10.1111/j.1365-277X.2010.01093.x
   Vitola JV, 2004, NUCL CARDIOLOGY CORR, P84
   Vranian MN, 2013, AM J CARDIOL, V111, P991, DOI 10.1016/j.amjcard.2012.12.022
   Williams PT, 2001, MED SCI SPORT EXER, V33, P754, DOI 10.1097/00005768-200105000-00012
NR 27
TC 49
Z9 60
U1 0
U2 30
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
EI 1879-1913
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD FEB 15
PY 2014
VL 113
IS 4
BP 637
EP 643
DI 10.1016/j.amjcard.2013.11.010
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AB4PQ
UT WOS:000331772800011
PM 24360775
DA 2025-06-11
ER

PT J
AU Seo, Y
   Je, Y
AF Seo, Yuri
   Je, Youjin
TI A comparative study on cardiovascular disease risk factors in Korean
   adults according to clinical depression status
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Depression; Body mass index; Metabolic syndrome; Cardiovascular disease
ID METABOLIC SYNDROME; MAJOR DEPRESSION; ALCOHOL-USE; ANXIETY;
   ASSOCIATIONS; DETERMINANTS; NUTRITION; SMOKING; OBESITY; HEALTH
AB This study was conducted to compare the association between depression and cardiovascular disease risk factors among Korean adults. This study was based on the data from the Korea National Health and Nutrition Examination Survey conducted in 2012-2014. Using a multivariable logistic regression model, we calculated odds ratios (ORs) and 95% confidence intervals (Cis). A total of 10,359 subjects aged 19-64 years were selected, and 432 subjects (74 men, 358 women) were included in the physician-diagnosed depression group. Several cardiovascular risk factors were associated with higher odds of clinical depression. For men, high waist circumference (>= 91.3 cm) and body mass index (>= 25.0 kg/m(2)) were significantly associated with increased odds of depression, and high physical activity (>= 50 MET h/week) was associated with decreased odds of depression. Men with dyslipidemia and metabolic syndrome had 2.43-fold and 2.0-fold higher odds of depression than those without the diseases. For women, current smokers had 2.25-fold higher odds of depression than nonsmokers, and frequent alcohol drinkers (>= 4 times/week) also had 2.88-fold higher odds of depression than nondrinkers. Korean adults with clinical depression had a higher prevalence of some risk factors for cardiovascular diseases than those without depression.
C1 [Seo, Yuri; Je, Youjin] Kyung Hee Univ, Dept Food & Nutr, 26 Kyunghee Daero, Seoul 02447, South Korea.
C3 Kyung Hee University
RP Je, Y (corresponding author), Kyung Hee Univ, Dept Food & Nutr, 26 Kyunghee Daero, Seoul 02447, South Korea.
EM youjinje@khu.ac.kr
RI Je, Youjin/N-2822-2018
OI Je, Youjin/0000-0002-2099-4204
FU Basic Science Research Program through the National Research Foundation
   of Korea - Ministry of Science, ICT and Future Planning
   [NRF-2015R1A1A1A05001362]
FX This work was supported by the Basic Science Research Program through
   the National Research Foundation of Korea, funded by the Ministry of
   Science, ICT and Future Planning (NRF-2015R1A1A1A05001362). Funders had
   no role in the study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
CR Ainsworth BE, 2000, MED SCI SPORT EXER, V32, pS498, DOI 10.1097/00005768-200009001-00009
   Anagnostis P, 2009, J CLIN ENDOCR METAB, V94, P2692, DOI 10.1210/jc.2009-0370
   [Anonymous], 2000, ASIA PACIFIC PERSPEC
   [Anonymous], 2015, Global Burden of Disease Study 2013. China Global Burden of Disease Study 2013 (GBD 2013) Results 1990-2013
   Bradley SM, 2015, TRENDS CARDIOVAS MED, V25, P614, DOI 10.1016/j.tcm.2015.02.002
   Breslau N, 1998, ARCH GEN PSYCHIAT, V55, P161, DOI 10.1001/archpsyc.55.2.161
   Carney RM, 2003, BIOL PSYCHIAT, V54, P241, DOI 10.1016/S0006-3223(03)00111-2
   CHOBANIAN AV, 2003, JAMA-J AM MED ASSOC, V289, P2560, DOI DOI 10.1161/01.HYP.0000107251.49515.C2
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hatzenbuehler ML, 2009, OBESITY, V17, P2033, DOI 10.1038/oby.2009.131
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Kodaman N, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0162753
   Korea Centers for Disease Control and Prevention, 2008, 2007 KOR NAT HLTH ST
   Korea Centers for Disease Control and Prevention, 2014, KOR HLTH STAT 2014 K
   Korean Diabetes Association, 2016, RANG HEM A1C HBA1C
   Lett HS, 2004, PSYCHOSOM MED, V66, P305, DOI 10.1097/01.psy.0000126207.43307.c0
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   MCLAUGHLIN RJ, 1985, J STUD ALCOHOL, V46, P212, DOI 10.15288/jsa.1985.46.212
   Mushtaq M, 2014, PAK J MED SCI, V30, P1293, DOI 10.12669/pjms.306.5433
   Nagarajan M., 1973, ALCOHOL INTOXICATION, VII, P351
   Nakata A, 2008, PREV MED, V46, P451, DOI 10.1016/j.ypmed.2008.01.024
   Nam Sujung, 2012, [Korean Journal of Human Ecology, 한국생활과학회지], V21, P1199
   Nangia R, 2016, Med J Armed Forces India, V72, P315
   Organization W.H., 2017, Depression and other common mental disorders: Global health estimates
   Pan A, 2008, J AFFECT DISORDERS, V109, P75, DOI 10.1016/j.jad.2007.11.002
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Park JE, 2011, PSYCHIAT RES, V190, P232, DOI 10.1016/j.psychres.2011.05.040
   Seldenrijk A, 2015, J PSYCHOSOM RES, V78, P123, DOI 10.1016/j.jpsychores.2014.10.007
   Strine TW, 2008, GEN HOSP PSYCHIAT, V30, P127, DOI 10.1016/j.genhosppsych.2007.12.008
   van Marwijk HWJ, 2015, BMC CARDIOVASC DISOR, V15, DOI 10.1186/s12872-015-0036-y
   Wang JL, 2002, DEPRESS ANXIETY, V15, P42, DOI 10.1002/da.1084
   Xu QY, 2011, OBES RES CLIN PRACT, V5, pE267, DOI 10.1016/j.orcp.2011.04.007
   Zhai L, 2015, BRIT J SPORT MED, V49, P705, DOI 10.1136/bjsports-2014-093613
NR 34
TC 7
Z9 8
U1 1
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD MAY
PY 2018
VL 263
BP 88
EP 93
DI 10.1016/j.psychres.2018.02.052
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GF8PK
UT WOS:000432234600015
PM 29510344
DA 2025-06-11
ER

PT J
AU Batrakoulis, A
AF Batrakoulis, Alexios
TI Psychophysiological Adaptations to Yoga Practice in Overweight and Obese
   Individuals: A Topical Review
SO DISEASES
LA English
DT Review
DE yoga; exercise; overweight; obesity; physiological responses;
   psychological responses
ID LIFE-STYLE INTERVENTION; QUALITY-OF-LIFE; LOW-BACK-PAIN;
   PHYSICAL-ACTIVITY; MENTAL-HEALTH; MUSCULOSKELETAL FITNESS; METABOLIC
   SYNDROME; WORLDWIDE SURVEY; LIPID PROFILE; PUBLIC-HEALTH
AB Physical activity has been documented as a foundational approach for weight management and obesity, improving several cardiometabolic and mental health indices. However, it is not clear whether yoga practice can induce beneficial improvements in anthropometric and body composition parameters, performance, metabolic health, and well-being among overweight/obese people. The aim of this topical review was to catalog training studies examining the psychophysiological responses to yoga interventions in order to detect which outcomes have been investigated, the research methods applied, and the conclusions. The inclusion/exclusion criteria were met by 22 published articles involving 1178 (56% female) overweight/obese participants. This brief review on yoga-induced adaptations demonstrates that this widely used meditative movement activity can meaningfully improve the vast majority of the selected markers. These beneficial alterations are focused mostly on various anthropometric and body composition variables, cardiovascular disease risk factors, physical fitness parameters, quality of life, and stress in previously inactive overweight/obese individuals. Instead, yoga-based physical exercise interventions investigating anxiety, depression, mood state, exercise enjoyment, affect valence, and adherence were limited. Further research should focus on the yoga intervention configuration and potential mechanisms behind favorable changes in various psychophysiological indices through large-scale, rigorously designed randomized controlled trials implementing long-term interventions in overweight/obese individuals.
C1 [Batrakoulis, Alexios] Univ Thessaly, Dept Phys Educ & Sport Sci, Trikala 42100, Greece.
C3 University of Thessaly
RP Batrakoulis, A (corresponding author), Univ Thessaly, Dept Phys Educ & Sport Sci, Trikala 42100, Greece.
EM abatrakoulis@uth.gr
RI Batrakoulis, Alexios/AAE-4820-2022
CR Anita Herur Anita Herur, 2010, Al Ameen Journal of Medical Sciences, V3, P337
   [Anonymous], NONC DIS COUNTR PROF
   Baird SO, 2016, BEHAV MODIF, V40, P199, DOI 10.1177/0145445515612401
   Baker A, 2016, J OBES, V2016, DOI 10.1155/2016/6169890
   Batrakoulis A, 2020, International Journal of Human Movement and Sports Sciences, V8, P308, DOI [10.13189/saj.2020.080602, DOI 10.13189/SAJ.2020.080602]
   Batrakoulis A, 2022, DISEASES-BASEL, V10, DOI 10.3390/diseases10040071
   Batrakoulis A, 2022, SPORTS, V10, DOI 10.3390/sports10050064
   Batrakoulis A, 2022, CIRC-CARDIOVASC QUAL, V15, P433, DOI 10.1161/CIRCOUTCOMES.121.008243
   Batrakoulis A, 2023, EUR J SPORT SCI, V23, P432, DOI 10.1080/17461391.2021.2025434
   Batrakoulis A, 2021, ACSMS HEALTH FIT J, V25, P54, DOI 10.1249/FIT.0000000000000703
   Batrakoulis A, 2021, J SPORT SCI, V39, P503, DOI 10.1080/02640414.2020.1830543
   Batrakoulis A, 2019, ACSMS HEALTH FIT J, V23, P28, DOI 10.1249/FIT.0000000000000523
   Batrakoulis A, 2020, EUR J SPORT SCI, V20, P783, DOI 10.1080/17461391.2019.1663270
   Batrakoulis A, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0202390
   Birdee GS, 2008, J GEN INTERN MED, V23, P1653, DOI 10.1007/s11606-008-0735-5
   Blair SN, 2009, BRIT J SPORT MED, V43, P1
   Braun Tosca D, 2012, Int J Yoga Therap, P9
   Brinsley J, 2021, COMPLEMENT THER MED, V56, DOI 10.1016/j.ctim.2020.102618
   Büssing A, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/165410
   Bull FC, 2020, BRIT J SPORT MED, V54, P1451, DOI 10.1136/bjsports-2020-102955
   Burgess E, 2017, CLIN OBES, V7, P105, DOI 10.1111/cob.12180
   Caldwell AE, 2022, OBES SCI PRACT, V8, P219, DOI 10.1002/osp4.552
   Canuto R, 2021, OBES REV, V22, DOI 10.1111/obr.13143
   Carraça EV, 2021, OBES REV, V22, DOI 10.1111/obr.13261
   Chen SS, 2022, FRONT SPORTS ACT LIV, V4, DOI 10.3389/fspor.2022.900815
   Clarke Tainya C, 2018, NCHS Data Brief, P1
   Clarke Tainya C, 2015, Natl Health Stat Report, P1
   Collins C, 1998, J Obstet Gynecol Neonatal Nurs, V27, P563
   Cramer H, 2019, BMC COMPLEM ALTERN M, V19, DOI 10.1186/s12906-019-2612-7
   Cramer H, 2018, DEPRESS ANXIETY, V35, P830, DOI 10.1002/da.22762
   Cramer H, 2018, J SCI MED SPORT, V21, P147, DOI 10.1016/j.jsams.2017.08.026
   Cramer H, 2017, J AFFECT DISORDERS, V213, P70, DOI 10.1016/j.jad.2017.02.006
   Cramer H, 2016, DTSCH ARZTEBL INT, V113, P645, DOI 10.3238/arztebl.2016.0645
   Cramer H, 2016, AM J PREV MED, V50, P230, DOI 10.1016/j.amepre.2015.07.037
   Cramer H, 2015, AM J EPIDEMIOL, V182, P281, DOI 10.1093/aje/kwv071
   Cramer H, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0075515
   D'Souza AC, 2022, BRIT J SPORT MED, V56, P771, DOI 10.1136/bjsports-2021-104754
   Dai CL, 2021, ALTERN THER HEALTH M, V27, P47
   de Manincor M, 2015, BMC COMPLEM ALTERN M, V15, DOI 10.1186/s12906-015-0614-7
   de Wit LM, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-14
   Desikachar K., 2005, INT J YOGA THER, V15, P17, DOI DOI 10.17761/IJYT.15.1.P501L33535230737
   Dhananjai S, 2013, Int J Yoga, V6, P66, DOI 10.4103/0973-6131.105949
   Do Kathy, 2018, BMC Obes, V5, P5, DOI 10.1186/s40608-018-0183-7
   Domingues RB, 2018, COMPLEMENT THER CLIN, V31, P248, DOI 10.1016/j.ctcp.2018.03.002
   Estevao C, 2022, BRAIN BEHAV IMMUN-HL, V20, DOI 10.1016/j.bbih.2022.100421
   Forseth B, 2022, CHILD OBES, V18, P67, DOI 10.1089/chi.2021.0114
   Garber CE, 2019, CURR SPORT MED REP, V18, P287, DOI 10.1249/JSR.0000000000000619
   Gariepy G, 2010, INT J OBESITY, V34, P407, DOI 10.1038/ijo.2009.252
   Gasmi A, 2021, Arch Razi Inst, V76, P707, DOI 10.22092/ari.2021.356057.1768
   Ghazvineh D, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.942702
   Gothe NP, 2016, J GERONTOL A-BIOL, V71, P406, DOI 10.1093/gerona/glv127
   Govindaraj R, 2016, INT REV PSYCHIATR, V28, P242, DOI 10.3109/09540261.2016.1160878
   Grieve E, 2013, OBES REV, V14, P883, DOI 10.1111/obr.12059
   Guo YH, 2014, INT J CLIN EXP MED, V7, P5842
   Guthold R, 2018, LANCET GLOB HEALTH, V6, pE1077, DOI [10.1016/S2214-109X(18)30357-7, 10.1016/s2214-109x(18)30357-7]
   Hagins Marshall, 2007, BMC Complement Altern Med, V7, P40, DOI 10.1186/1472-6882-7-40
   Hainsworth KR, 2018, CHILDREN-BASEL, V5, DOI 10.3390/children5070092
   Hartley L, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010072.pub2
   Hendriks T, 2017, J ALTERN COMPLEM MED, V23, P505, DOI 10.1089/acm.2016.0334
   Hewett ZL, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1740-1
   Holtzman S, 2013, PAIN RES MANAG, V18, P267, DOI 10.1155/2013/105919
   Hopkins LB, 2016, J CONSULT CLIN PSYCH, V84, P558, DOI 10.1037/ccp0000091
   Hunter SD, 2016, J PHYS ACT HEALTH, V13, P1360, DOI 10.1123/jpah.2016-0170
   Hunter SD, 2013, J BODYW MOV THER, V17, P404, DOI 10.1016/j.jbmt.2013.01.002
   Innes KE, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/6979370
   International Health Racquet and SportsClub Association, 2019, 2020 IHRSA HLTH CLUB
   Jakicic JM, 2021, OBESITY, V29, P512, DOI 10.1002/oby.23089
   James-Palmer A, 2020, FRONT PEDIATR, V8, DOI 10.3389/fped.2020.00078
   Jayawardena R, 2020, INT J YOGA, V13, P99, DOI 10.4103/ijoy.IJOY_37_19
   Jeong Y, 2018, ERGONOMICS, V61, P1223, DOI 10.1080/00140139.2018.1478455
   Johnson NA, 2021, J SCI MED SPORT, V24, P1245, DOI 10.1016/j.jsams.2021.07.009
   Jorrakate C, 2015, J PHYS THER SCI, V27, P59, DOI 10.1589/jpts.27.59
   Jung ME, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/191595
   Kannan RS, 2019, Int J Phys Educ Sports Health, V6, P190
   Kell RT, 2001, SPORTS MED, V31, P863, DOI 10.2165/00007256-200131120-00003
   Kercher V, 2019, ACSMS HEALTH FIT J, V23, P41, DOI 10.1249/FIT.0000000000000531
   Kercher VM, 2022, ACSMS HEALTH FIT J, V26, P21, DOI 10.1249/FIT.0000000000000737
   Kercher VM, 2018, ACSMS HEALTH FIT J, V22, P24, DOI 10.1249/FIT.0000000000000431
   Kercher VM, 2021, ACSMS HEALTH FIT J, V25, P20, DOI 10.1249/FIT.0000000000000639
   Khoshnaw DM, 2021, J INTEGR MED-JIM, V19, P6, DOI 10.1016/j.joim.2020.09.002
   Kim KB, 2019, J OBES METAB SYNDR, V28, P278
   Kumar V, 2016, COMPLEMENT THER MED, V25, P104, DOI 10.1016/j.ctim.2016.02.001
   Latino F, 2021, SUSTAINABILITY-BASEL, V13, DOI 10.3390/su13042104
   Lauche R, 2016, PREV MED, V87, P213, DOI 10.1016/j.ypmed.2016.03.013
   Lee HS, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18052635
   Lee JA, 2012, MENOPAUSE, V19, P296, DOI 10.1097/gme.0b013e31822d59a2
   Liguori G, 2021, Acsm's Guidelines for Exercise Testing and Prescription, V11th
   Lin XH, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.706978
   Luque M, 2016, IDEA FIT J, V13, P40
   Manchanda SC, 2014, CLIN RES CARDIOL, V103, P675, DOI 10.1007/s00392-014-0663-9
   Montesi L, 2016, DIABET METAB SYND OB, V9, P37, DOI 10.2147/DMSO.S89836
   Nongkhai MPN, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/6702767
   Naderi, 2021, EVIDENCE BASED CARE, V11, P16
   Netam R, 2015, INDIAN J MED RES, V141, P775, DOI 10.4103/0971-5916.160698
   Nongkhai MPN, 2022, HELIYON, V8, DOI 10.1016/j.heliyon.2022.e10661
   Park CL, 2016, J HEALTH PSYCHOL, V21, P887, DOI 10.1177/1359105314541314
   Park CL, 2015, J BEHAV MED, V38, P460, DOI 10.1007/s10865-015-9618-5
   Pataky Z, 2014, OBESITY, V22, P56, DOI 10.1002/oby.20514
   Patwardhan AR, 2017, J PRIM CARE COMMUNIT, V8, P31, DOI 10.1177/2150131916664682
   Pearsall R, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/1471-244X-14-117
   Posadzki P, 2011, COMPLEMENT THER MED, V19, P281, DOI 10.1016/j.ctim.2011.07.004
   Pryor JL, 2019, J PHYS ACT HEALTH, V16, P575, DOI 10.1123/jpah.2018-0283
   Puente-Maestu L, 2018, EUR RESPIR J, V51, DOI 10.1183/13993003.02468-2017
   Ray US, 2011, EVID-BASED COMPL ALT, V2011, P1, DOI 10.1093/ecam/neq046
   Rshikesan P B, 2017, Int J Yoga, V10, P128, DOI [10.4103/ijoy.ijoy_53_16, 10.4103/ijoy.IJOY_53_16]
   Rshikesan PB, 2016, J CLIN DIAGN RES, V10, pOC22, DOI 10.7860/JCDR/2016/22720.8940
   Rshikesan PB, 2016, J CLIN DIAGN RES, V10, pKC1, DOI 10.7860/JCDR/2016/21494.8727
   Salmon J, 2003, HEALTH PSYCHOL, V22, P178, DOI 10.1037/0278-6133.22.2.178
   Sarvottam K, 2013, J ALTERN COMPLEM MED, V19, P397, DOI 10.1089/acm.2012.0086
   Scott KM, 2008, INT J OBESITY, V32, P192, DOI 10.1038/sj.ijo.0803701
   Seo DY, 2012, KOREAN J PHYSIOL PHA, V16, P175, DOI 10.4196/kjpp.2012.16.3.175
   Sharma P, 2022, FRONT MED-LAUSANNE, V9, DOI 10.3389/fmed.2022.898293
   Sharma P, 2022, J INTEGR COMPLEMENT, V28, P168, DOI 10.1089/jicm.2021.0215
   Sherman KJ, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/143271
   Sherman SA, 2017, J PHYS ACT HEALTH, V14, P597, DOI 10.1123/jpah.2016-0548
   Shin S, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph182111663
   Shohani M, 2018, INT J PREVENTIVE MED, V9, DOI 10.4103/ijpvm.IJPVM_242_16
   Siu PM, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/s13098-015-0034-3
   Sivananda S.S., 1981, HATHA YOGA SCI YOGA, V4
   Sivaramakrishnan D, 2019, INT J BEHAV NUTR PHY, V16, DOI 10.1186/s12966-019-0789-2
   Soleymani T, 2016, OBES REV, V17, P81, DOI 10.1111/obr.12322
   Sovova Eliska, 2015, Int J Yoga, V8, P134, DOI 10.4103/0973-6131.158482
   Stutts Wanda C, 2002, AAOHN J, V50, P499
   Swain TA, 2016, ORTHOP J SPORTS MED, V4, DOI 10.1177/2325967116671703
   Telles S, 2021, COMPLEMENT THER MED, V57, DOI 10.1016/j.ctim.2020.102644
   Telles S, 2019, J OBES, V2019, DOI 10.1155/2019/9895074
   Telles S, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00466
   Telles S, 2017, FRONT PUBLIC HEALTH, V5, DOI 10.3389/fpubh.2017.00184
   Telles S, 2014, MED SCI MONITOR, V20, P894, DOI 10.12659/MSM.889805
   ten Hoor GA, 2017, SPORTS MED, V47, P2069, DOI 10.1007/s40279-017-0748-5
   Thompson WR, 2022, ACSMS HEALTH FIT J, V26, P11, DOI 10.1249/FIT.0000000000000732
   Tremmel M, 2017, INT J ENV RES PUB HE, V14, DOI 10.3390/ijerph14040435
   Trost SG, 2002, MED SCI SPORT EXER, V34, P1996, DOI 10.1097/00005768-200212000-00020
   Türk Y, 2017, OBES SCI PRACT, V3, P258, DOI 10.1002/osp4.109
   Unick JL, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0263405
   Vergeer I, 2018, COMPLEMENT THER CLIN, V31, P181, DOI 10.1016/j.ctcp.2018.02.011
   Viswanathan V, 2021, DIABETES RES CLIN PR, V172, DOI 10.1016/j.diabres.2020.108644
   Wang FF, 2020, ALTERN THER HEALTH M, V26, P58
   Wang J, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076357
   Warburton DER, 2001, CAN J APPL PHYSIOL, V26, P217, DOI 10.1139/h01-013
   Wasser JG, 2017, PM&R, V9, P181, DOI 10.1016/j.pmrj.2016.06.019
   Weinberger NA, 2016, OBESITY FACTS, V9, P424, DOI 10.1159/000454837
   Wibowo RA, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19074199
   Widjaja W, 2021, COMPLEMENT THER CLIN, V43, DOI 10.1016/j.ctcp.2021.101345
   Woodyard Catherine, 2011, Int J Yoga, V4, P49, DOI 10.4103/0973-6131.85485
   World Health Organization Overweight and Obesity, WHO FACT SHEET
   Wu Y, 2019, MAYO CLIN PROC, V94, P432, DOI 10.1016/j.mayocp.2018.09.023
   Yadav R, 2016, J ALTERN COMPLEM MED, V22, P443, DOI 10.1089/acm.2015.0268
NR 148
TC 27
Z9 28
U1 1
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2079-9721
J9 DISEASES-BASEL
JI Diseases
PD DEC
PY 2022
VL 10
IS 4
AR 107
DI 10.3390/diseases10040107
PG 21
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA 7D4GI
UT WOS:000900450400001
PM 36412601
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Maayan, L
   Kalanthroff, E
   Cohen, E
   Neria, Y
AF Maayan, Lawrence
   Kalanthroff, Eyal
   Cohen, Ezra
   Neria, Yuval
TI Potential metabolic sequelae to the terrorist attack of October 7th,
   2023
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
ID POSTTRAUMATIC-STRESS-DISORDER; ISRAELI CIVILIANS; SEXUAL VIOLENCE;
   MENTAL-HEALTH; EPIGENETIC REGULATION; PTSD; RISK; ASSOCIATION; LIFE;
   INTERVENTION
AB Objective/hypothesis: Evaluate cardiometabolic risk as a potential sequel to a mass terrorist attack using October 7th, 2023 as a focus. Methods: Narrative review surveying PubMed, PsycNet, UN and Council on Foreign Relations websites on. 1. PTSD following terrorism, rocket attacks and conflict related sexual violence. 2. The relationship between cardiometabolic illness and PTSD. 3. Humoral, genetic and epigenetic mechanisms relating cardiometabolic risk, inflammation and PTSD. 4. Treatments for PTSD and associated cardiometabolic risk factors and their effectiveness. Findings: Cardiometabolic sequelae occur after trauma. This is most pronounced when trauma, sexual or violence related, occurs during childhood. The risk of cardiometabolic sequelae increases with PTSD diagnosis in adults. Inflammation as well as genes related to inflammatory function (e.g. FKBP5, AHRR, NR3C1) impact vulnerability to PTSD, response to treatment and cardiometabolic outcomes. Treatments for PTSD appear somewhat more effective at lowering cardiometabolic risk in civilian, rather than military populations. There is little published research on directly treating cardiometabolic sequelae of PTSD. Conclusions: Israelis, particularly those with exposure to the terror events of October 7, 2023 should be screened for psychological and metabolic sequelae. This should occur in a primary care setting and be part of observational research to help understand relationships between trauma, metabolic outcomes and their treatment.
C1 [Maayan, Lawrence; Neria, Yuval] New York State Psychiat Inst & Hosp, 1051 Riverside Dr, New York, NY 10032 USA.
   [Kalanthroff, Eyal; Neria, Yuval] Columbia Coll Phys & Surg, Dept Psychiat, New York, NY USA.
   [Kalanthroff, Eyal] Hebrew Univ Jerusalem, Dept Psychol, Jerusalem, Israel.
   [Cohen, Ezra] SUNY Binghamton, Binghamton Univ, Binghamton, NY USA.
   [Neria, Yuval] Columbia Coll Phys & Surg, Dept Epidemiol, Columbia, NY USA.
C3 New York State Psychiatry Institute; Columbia University; Hebrew
   University of Jerusalem; State University of New York (SUNY) System;
   Binghamton University, SUNY
RP Maayan, L (corresponding author), New York State Psychiat Inst & Hosp, 1051 Riverside Dr, New York, NY 10032 USA.
EM Lawrence.maayan@nyspi.columbia.edu
FU New York State Psychiatric Institute
FX The authors wish to acknowledge the guidance of Dr. Franklin Schneier
   and the role of bridge funding at the New York State Psychiatric
   Institute in supporting the time used to prepare this manuscript.
CR Ahmadi N, 2011, AM J CARDIOL, V108, P29, DOI 10.1016/j.amjcard.2011.02.340
   Amsalem D, 2025, PSYCHIAT RES, V343, DOI 10.1016/j.psychres.2024.116280
   Arcan C, 2024, OBES SCI PRACT, V10, DOI 10.1002/osp4.725
   Bam M, 2016, J NEUROIMMUNE PHARM, V11, P168, DOI 10.1007/s11481-015-9643-8
   Bar-Haim Y, 2010, AM J PSYCHIAT, V167, P694, DOI 10.1176/appi.ajp.2009.09070956
   Ben Natan M, 2017, ARCH PSYCHIAT NURS, V31, P610, DOI 10.1016/j.apnu.2017.09.001
   Berger R, 2012, J ADOLESCENT HEALTH, V51, P453, DOI 10.1016/j.jadohealth.2012.02.011
   Besser A, 2009, J TRAUMA STRESS, V22, P268, DOI 10.1002/jts.20420
   Braun J, 2019, J CLIN PSYCHIAT, V80, DOI 10.4088/JCP.19m12813
   Brown ES, 2000, COMPR PSYCHIAT, V41, P19, DOI 10.1016/S0010-440X(00)90126-3
   Cfr C.f., 2024, Conflict in the Democratic Republic of Congo
   Chemtob CM, 2002, ARCH PEDIAT ADOL MED, V156, P211, DOI 10.1001/archpedi.156.3.211
   Corcoran C, 2009, SCHIZOPHRENIA BULL, V35, P596, DOI 10.1093/schbul/sbn089
   Edmondson D, 2013, AM HEART J, V166, P806, DOI 10.1016/j.ahj.2013.07.031
   Feingold D, 2024, J PSYCHIATR RES, V174, P153, DOI 10.1016/j.jpsychires.2024.04.022
   Feldman R, 2020, WORLD PSYCHIATRY, V19, P132, DOI 10.1002/wps.20729
   Felitti VJ, 1998, AM J PREV MED, V14, P245, DOI 10.1016/S0749-3797(98)00017-8
   Gavrieli A, 2015, METABOLISM, V64, P1597, DOI 10.1016/j.metabol.2015.08.017
   Gil S, 2015, BRAIN BEHAV, V5, DOI 10.1002/brb3.316
   Gill JM, 2013, J PSYCHOSOM RES, V74, P301, DOI 10.1016/j.jpsychores.2012.10.013
   Gilsanz P., 2017, Psychol. Med.
   Goltser-Dubner T, 2023, MOL PSYCHIATR, V28, P3851, DOI 10.1038/s41380-023-02278-7
   Green L, 2022, BMC PUBLIC HEALTH, V22, DOI 10.1186/s12889-022-13038-7
   Griffiths M., 2024, Statement by principals of the inter-agency standing committee on the democratic republic of the Congo:crushing levels of violence. Displacement Fuel Unprecedented Civilian Suffering
   Groweiss Y, 2024, PSYCHIAT RES, V337, DOI 10.1016/j.psychres.2024.115973
   Gupta MA, 2013, INT REV PSYCHIATR, V25, P86, DOI 10.3109/09540261.2012.736367
   Hall KS, 2020, J GERONTOL A-BIOL, V75, P2130, DOI 10.1093/gerona/glz255
   Hasson-Ohayon I, 2024, J TRAUMA STRESS, V37, P348, DOI 10.1002/jts.23026
   Havranek EP, 2015, CIRCULATION, V132, P873, DOI 10.1161/CIR.0000000000000228
   Heim C, 2000, JAMA-J AM MED ASSOC, V284, P592, DOI 10.1001/jama.284.5.592
   Heim C, 2009, ARCH GEN PSYCHIAT, V66, P72, DOI 10.1001/archgenpsychiatry.2008.508
   Hobfoll SE, 2008, J TRAUMA STRESS, V21, P9, DOI 10.1002/jts.20307
   Jakubowski KP, 2021, MATURITAS, V153, P48, DOI 10.1016/j.maturitas.2021.07.014
   Johnson K, 2010, JAMA-J AM MED ASSOC, V304, P553, DOI 10.1001/jama.2010.1086
   Kadour-Peero E, 2025, REPROD BIOMED ONLINE, V50, DOI 10.1016/j.rbmo.2024.104429
   Kalanthroff E., 2024, The Effect of Trauma on the Onset and Maintenance of OCD: the Case of Israel after October 7th
   Katrinli S, 2022, MOL PSYCHIATR, V27, P1720, DOI 10.1038/s41380-021-01398-2
   Katsoty D, 2024, medRxiv, DOI [10.1101/2024.02.25.24303235, 10.1186/s13584-024-00644-6, DOI 10.1186/S13584-024-00644-6]
   Kelly J, 2017, BMC WOMENS HEALTH, V17, DOI 10.1186/s12905-017-0479-7
   Kibler J, 2023, BRAIN SCI, V13, DOI 10.3390/brainsci13111565
   Kingsley P., 2024, The New York Times
   Kline NK, 2021, J INTERPERS VIOLENCE, V36, pNP3153, DOI 10.1177/0886260518770652
   Koenen KC, 2017, PSYCHOL MED, V47, P209, DOI [10.1017/s0033291716002294, 10.1017/S0033291716002294]
   Koren D, 2002, AM J PSYCHIAT, V159, P855, DOI 10.1176/appi.ajp.159.5.855
   Kuan PF, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/s41398-017-0050-1
   Lederer E., 2024, A UN Envoy Says There Are 'reasonable Grounds' to Believe Hamas Committed Sexual Violence on Oct. 7
   Lei CL, 2022, FRONT PSYCHIATRY, V13, DOI 10.3389/fpsyt.2022.857087
   Leshem S, 2023, EUR J PSYCHOTRAUMATO, V14, DOI 10.1080/20008066.2023.2235983
   Levi-Belz Y, 2024, J AFFECT DISORDERS, V356, P292, DOI 10.1016/j.jad.2024.04.055
   Levi-Belz Y, 2024, ECLINICALMEDICINE, V68, DOI 10.1016/j.eclinm.2023.102418
   Lichtman-Sadot S., 2020, Journal of demographic economics, P1
   Lohr JB, 2015, AM J GERIAT PSYCHIAT, V23, P709, DOI 10.1016/j.jagp.2015.04.001
   Maayan L., 2024, World Cultural Psychiatry Research Review
   Maayan L, 2024, J PSYCHIATR RES, V169, P364, DOI 10.1016/j.jpsychires.2023.11.025
   Maayan L, 2011, OBESITY, V19, P1382, DOI 10.1038/oby.2011.15
   Maayan L, 2010, EXPERT REV NEUROTHER, V10, P1175, DOI 10.1586/ERN.10.85
   Maples-Keller JL, 2022, BRAIN BEHAV IMMUN, V101, P84, DOI 10.1016/j.bbi.2021.12.025
   McGowan PO, 2009, NAT NEUROSCI, V12, P342, DOI 10.1038/nn.2270
   Mezrich JD, 2010, J IMMUNOL, V185, P3190, DOI 10.4049/jimmunol.0903670
   Michopoulos V, 2016, EXP NEUROL, V284, P220, DOI 10.1016/j.expneurol.2016.05.038
   Murray SM, 2018, CONFL HEALTH, V12, DOI 10.1186/s13031-018-0142-4
   Nacascn N, 2023, ISR MED ASSOC J, V25, P724
   Negriff S, 2023, DEV PSYCHOPATHOL, V35, P130, DOI 10.1017/S095457942100050X
   Neria Y, 2013, J TRAUMA STRESS, V26, P45, DOI 10.1002/jts.21767
   Neria Y, 2010, J TRAUMA STRESS, V23, P322, DOI 10.1002/jts.20522
   Nuttman-Shwartz O, 2023, TRAUMA VIOLENCE ABUS, V24, P1387, DOI 10.1177/15248380211063467
   O'Doherty Lorna, 2023, Cochrane Database Syst Rev, V10, pCD013456, DOI 10.1002/14651858.CD013456.pub2
   Orellana SC, 2024, P NATL ACAD SCI USA, V121, DOI 10.1073/pnas.2304704121
   Ou-Yang MC, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0232238
   Pagoto SL, 2012, OBESITY, V20, P200, DOI 10.1038/oby.2011.318
   Passos IC, 2015, LANCET PSYCHIAT, V2, P1002, DOI 10.1016/S2215-0366(15)00309-0
   Pat-Horenczyk R, 2007, AM J ORTHOPSYCHIAT, V77, P76, DOI 10.1037/0002-9432.77.1.76
   Pietrzak RH, 2011, PSYCHOSOM MED, V73, P697, DOI 10.1097/PSY.0b013e3182303775
   Power C, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0119985
   Provençal N, 2012, J NEUROSCI, V32, P15626, DOI 10.1523/JNEUROSCI.1470-12.2012
   Roer GE, 2023, BMC PSYCHIATRY, V23, DOI 10.1186/s12888-023-04866-x
   Rosenbaum S, 2015, METABOLISM, V64, P926, DOI [10.1016/j.metabol.2015.04.009, 10.1016/j.metabol.2015.01.016]
   Rubini E, 2023, INT J EQUITY HEALTH, V22, DOI 10.1186/s12939-023-02038-7
   Scherrer JF, 2020, J PSYCHOSOM RES, V134, DOI 10.1016/j.jpsychores.2020.110128
   Scherrer JF, 2020, HEALTH PSYCHOL, V39, P403, DOI 10.1037/hea0000855
   Schmitt S, 2021, SSM-POPUL HLTH, V13, DOI 10.1016/j.ssmph.2020.100719
   Scott KA, 2008, J PSYCHOSOM RES, V64, P97, DOI 10.1016/j.jpsychores.2007.09.006
   Segman RH, 2005, MOL PSYCHIATR, V10, P500, DOI 10.1038/sj.mp.4001636
   Sledjeski EM, 2008, J BEHAV MED, V31, P341, DOI 10.1007/s10865-008-9158-3
   Smith AK, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-19615-x
   Somer E, 2009, PREHOSPITAL DISASTER, V24, P389, DOI 10.1017/S1049023X00007196
   Song H, 2019, BMJ-BRIT MED J, V367, DOI 10.1136/bmj.l5784
   Song H, 2018, JAMA-J AM MED ASSOC, V319, P2388, DOI 10.1001/jama.2018.7028
   Souama C, 2024, PSYCHOL MED, V54, P1373, DOI 10.1017/S0033291723003264
   Spitzer C, 2009, PSYCHOSOM MED, V71, P1012, DOI 10.1097/PSY.0b013e3181bc76b5
   Stallone K, 2022, VIOLENCE AGAINST WOM, V28, P3482, DOI 10.1177/10778012211054872
   Stein BD, 2003, JAMA-J AM MED ASSOC, V290, P603, DOI 10.1001/jama.290.5.603
   Suderman M, 2014, BMC MED GENOMICS, V7, DOI 10.1186/1755-8794-7-13
   Sumner JA, 2023, TRANSL PSYCHIAT, V13, DOI 10.1038/s41398-023-02330-8
   Takemoto E, 2021, PSYCHOL MED, V51, P2647, DOI 10.1017/S0033291720001208
   Tartakovsky E, 2023, J INTERPERS VIOLENCE, V38, P2630, DOI 10.1177/08862605221102481
   The Commonwealth Fund, 2020, International Health Care System Profiles: Canada
   Tozzi L, 2018, NEUROPSYCHOPHARMACOL, V43, P1138, DOI 10.1038/npp.2017.290
   Trasande L, 2018, ENVIRON RES, V160, P107, DOI 10.1016/j.envres.2017.09.026
   Trickett PK, 2011, DEV PSYCHOPATHOL, V23, P453, DOI 10.1017/S0954579411000174
   Tyrka AR, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030148
   Uddin M, 2010, P NATL ACAD SCI USA, V107, P9470, DOI 10.1073/pnas.0910794107
   UN, 2024, Mission Report. Official Visit of the Office of the SRSG-SVC to Israel and the Occupied West Bank
   United Nations H.C., 2024, Situation of Human Rights in the Sudan
   Vieweg WVR, 2007, ACTA PSYCHIAT SCAND, V116, P483, DOI 10.1111/j.1600-0447.2007.01071.x
   Vieweg W Victor R, 2006, Prim Care Companion J Clin Psychiatry, V8, P25
   Vinkers CH, 2021, MOL PSYCHIATR, V26, P1264, DOI 10.1038/s41380-019-0549-3
   Wilkins SS, 2021, J AM GERIATR SOC, V69, P1045, DOI 10.1111/jgs.16973
   Wolmer L, 2011, J AM ACAD CHILD PSY, V50, P340, DOI 10.1016/j.jaac.2011.01.002
   Wood EJ, 2014, INT REV RED CROSS, V96, P457, DOI 10.1017/S1816383115000077
   Yang RT, 2021, TRANSL PSYCHIAT, V11, DOI 10.1038/s41398-021-01513-5
   Yehuda R, 2013, FRONT PSYCHIATRY, V4, DOI 10.3389/fpsyt.2013.00118
   Yehuda R, 2009, BIOL PSYCHIAT, V66, P708, DOI 10.1016/j.biopsych.2009.02.034
   Zohar J, 2014, EUR NEUROPSYCHOPHARM, V24, P117, DOI 10.1016/j.euroneuro.2013.10.009
NR 114
TC 0
Z9 0
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD FEB
PY 2025
VL 182
BP 452
EP 461
DI 10.1016/j.jpsychires.2025.01.033
EA JAN 2025
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA X2M4F
UT WOS:001423753200001
PM 39892214
DA 2025-06-11
ER

PT J
AU Arzoz-Fabregas, M
   Ibarz-Servio, L
   Edo-Izquierdo, S
   Doladé-Botías, M
   Fernandez-Castro, J
   Roca-Antonio, J
AF Arzoz-Fabregas, Montserrat
   Ibarz-Servio, Luis
   Edo-Izquierdo, Silvia
   Dolade-Botias, Maria
   Fernandez-Castro, Jordi
   Roca-Antonio, Josep
TI Chronic stress and calcium oxalate stone disease: is it a potential
   recurrence risk factor?
SO UROLITHIASIS
LA English
DT Article
DE Stress; Stone formers; First-time stone formers; Recurrent stone
   formers; Calcium oxalate
ID METABOLIC SYNDROME; PSYCHOMETRIC PROPERTIES; LIFE EVENTS; DEPRESSION;
   ANXIETY; SATISFACTION; SCALE
AB Chronic emotional stress is associated with increased cortisol release and metabolism disorders. However, few studies have evaluated the influence of chronic stress on calcium oxalate (CaOx) stone disease and its recurrence. A total of 128 patients were enrolled in this case-control study over a period of 20 months. All patients were CaOx stone formers with a recent stone episode (<3 months); 31 were first-time stone formers (FS) and 33 recurrent stone formers (RS). Dimensions of chronic stress were evaluated with self-reported validated questionnaires measuring stressful life events, perceived stress, anxiety, depression, burnout and satisfaction with life. An ad hoc self-reporting questionnaire was designed to evaluate stress-related specifically to stone episodes. Blood and urine samples were collected to determine cortisol levels and urinary composition. In addition, epidemiological data, socioeconomic information, diet and incidences of metabolic syndrome (MS) were reported. Overall, no significant differences were observed in the scores of cases and controls on any of the questionnaires dealing with stress. The number (p < 0.001) and the intensity (p < 0.001) of perceived stressful life events were higher in RS than in FS, but there were no differences between the two groups in other dimensions of stress. RS had higher glucose (p = 0.08), uric acid (p = 0.02), blood cortisol (p = 0.01), and urine calcium levels (p = 0.01) than FS. RS also had lower economic levels (p = 0.02) and more frequent incidences of MS (p = 0.07) than FS. Although no differences were observed in cases and controls among any dimension of chronic stress, the number and intensity of stressful life events were higher in RS than in FS. These differences correlate with variations in blood and urinary levels and with metabolic disorders, indicating an association between chronic stress and risk of recurrent CaOx stone formation.
C1 [Arzoz-Fabregas, Montserrat; Ibarz-Servio, Luis] Hosp Badalona Germans Trias & Pujol, Dept Urol, Badalona 08916, Barcelona, Spain.
   [Edo-Izquierdo, Silvia; Fernandez-Castro, Jordi] Autonomous Univ Barcelona, Dept Psychol, Bellaterra, Spain.
   [Dolade-Botias, Maria] Hosp Badalona Germans Trias & Pujol, Dept Biochem, Badalona 08916, Barcelona, Spain.
   [Roca-Antonio, Josep] Hosp Badalona Germans Trias & Pujol, Dept Epidemiol, Badalona 08916, Barcelona, Spain.
C3 Hospital Germans Trias i Pujol; Autonomous University of Barcelona;
   Hospital Germans Trias i Pujol; Hospital Germans Trias i Pujol
RP Arzoz-Fabregas, M (corresponding author), Hosp Badalona Germans Trias & Pujol, Dept Urol, Crta Canyet S-N, Badalona 08916, Barcelona, Spain.
EM montsearzoz@hotmail.com
RI ; Edo, Silvia/L-3271-2014; Fernandez-Castro, Jordi/L-6166-2014
OI Arzoz, Montserrat/0000-0002-6438-4870; Edo, Silvia/0000-0002-6564-3475;
   Fernandez-Castro, Jordi/0000-0001-7725-3506; Dolade Botias,
   Maria/0000-0001-8263-3087
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   ASPER R, 1984, UROL RES, V12, P1
   Atienza FL, 2000, PSICOTHEMA, V12, P314
   Berg W, 2010, UROL RES, V38, P161, DOI 10.1007/s00240-010-0273-6
   Chrousos GP, 2009, NAT REV ENDOCRINOL, V5, P374, DOI 10.1038/nrendo.2009.106
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   DIENER E, 1985, J PERS ASSESS, V49, P71, DOI 10.1207/s15327752jpa4901_13
   Diniz DHMP, 2007, BRAZ J MED BIOL RES, V40, P949, DOI 10.1590/S0100-879X2007000700009
   Diniz DHMP, 2006, J UROLOGY, V176, P2483, DOI 10.1016/j.juro.2006.07.156
   Fernandez-Castro J., 1994, Ansiedad y estres, 0, P127
   Fernandez-Seara JL, 1992, EAE ESCALAS APRECIAC
   Ferrari P, 2002, J AM SOC NEPHROL, V13, P2540, DOI 10.1097/01.ASN.0000028640.78526.0F
   Gaab J, 2005, PSYCHONEUROENDOCRINO, V30, P599, DOI 10.1016/j.psyneuen.2005.02.001
   Grases G, 2006, MAGNESIUM RES, V19, P102
   Kasl S., 1996, HDB STRESS MED HLTH, P13
   Kemeny ME, 2003, CURR DIR PSYCHOL SCI, V12, P124, DOI 10.1111/1467-8721.01246
   Nabkasorn C, 2006, EUR J PUBLIC HEALTH, V16, P179, DOI 10.1093/eurpub/cki159
   Najem GR, 1997, INT J EPIDEMIOL, V26, P1017, DOI 10.1093/ije/26.5.1017
   Pines A., 1998, CAREER BURNOUT CAUSE
   Rasmusson AM, 2010, EXP BIOL MED, V235, P1150, DOI 10.1258/ebm.2010.009334
   Remor E, 2006, SPAN J PSYCHOL, V9, P86, DOI 10.1017/S1138741600006004
   Rendina D, 2009, NEPHROL DIAL TRANSPL, V24, P900, DOI 10.1093/ndt/gfn548
   Sapolsky R, 2006, INVESTIGACION CIENCI, V353, P24
   Schenider HJ, 1985, UROLITHIASIS ETIOLOG, P138
   SCHMUCKI O, 1984, UROL INT, V39, P159, DOI 10.1159/000280966
   Taylor SE, 2007, ESTRES, P152
   Tejero A, 1986, Rev Psiquiatria Fac Med Barna, V13, P233
   WALTERS D C, 1986, International Urology and Nephrology, V18, P271, DOI 10.1007/BF02082713
   West B, 2008, AM J KIDNEY DIS, V51, P741, DOI 10.1053/j.ajkd.2007.12.030
   WILLETT WC, 1985, AM J EPIDEMIOL, V122, P51, DOI 10.1093/oxfordjournals.aje.a114086
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 31
TC 7
Z9 7
U1 0
U2 15
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 2194-7228
EI 2194-7236
J9 UROLITHIASIS
JI Urolithiasis
PD APR
PY 2013
VL 41
IS 2
BP 119
EP 127
DI 10.1007/s00240-013-0544-0
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 136CD
UT WOS:000318336500004
PM 23503873
DA 2025-06-11
ER

PT J
AU Ward, T
   Wynaden, D
   Heslop, K
AF Ward, Tamara
   Wynaden, Dianne
   Heslop, Karen
TI Who is responsible for metabolic screening for mental health clients
   taking antipsychotic medications?
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE audit; leadership; mental health nursing; metabolic screening; metabolic
   syndrome
ID PHYSICAL HEALTH; PRIMARY-CARE; NURSES ATTITUDES; TRAINING NEEDS; PEOPLE;
   ILLNESS; CONSUMERS; SCHIZOPHRENIA; GUIDELINES; PSYCHOSIS
AB Metabolic syndrome is common in mental health consumer populations, and is linked to cardiovascular disease, stroke and diabetes. Metabolic screening is a way of recognising consumers who are at risk of developing metabolic syndrome but internationally screening rates remain low. A retrospective audit was completed at one Australian public mental health service on the case files of 100 randomly selected consumers to determine nurses level of compliance with metabolic screening policies over a 12month period. Consumers included in the review were prescribed antipsychotic medications for at least 12months and had their care in the community coordinated by mental health nurses. Data were entered into an Excel spreadsheet for analysis. Low levels of metabolic screening were identified and these levels decreased over the 12months under review. No consumers had metabolic screening that recorded all parameters at three monthly intervals over the 12month period. Only one consumer had every metabolic parameter recorded on the physical health screen tool at baseline assessment. The findings demonstrated that while there is increased awareness of co-morbid physical health issues in this consumer population, the translation of guidelines and policy directives to clinical practice to address this disparity remains low. Improving physical health outcomes is the responsibility of all health professionals, particularly doctors who prescribe and nurses who administer antipsychotic medications regularly to mental health consumers. Moreover, nurses are well placed to demonstrate leadership in reducing the rate of metabolic syndrome through the delivery of holistic care that includes effective screening programs.
C1 [Ward, Tamara; Wynaden, Dianne; Heslop, Karen] Curtin Univ, Nursing Midwifery & Paramed, Perth, WA, Australia.
C3 Curtin University
RP Wynaden, D (corresponding author), Curtin Univ, Sch Nursing Midwifery & Paramed, GPO Box U 1987, Perth, WA 6845, Australia.
EM d.wynaden@curtin.edu.au
RI Heslop, Karen/AFM-4040-2022
OI Wynaden, Dianne/0000-0002-3985-7621; Heslop, Karen/0000-0002-1136-3718
CR Australian Commission on Quality and Safety in Health Care, 2014, AC MENT HLTH CAR QUM
   Australian Medicine Handbook, 2015, AUSTR MED HDB
   Bergqvist A, 2013, ISSUES MENT HEALTH N, V34, P350, DOI 10.3109/01612840.2013.771234
   Brunero S, 2009, INT J MENT HEALTH NU, V18, P144, DOI 10.1111/j.1447-0349.2009.00595.x
   Chacon F., 2011, ANN GEN PSYCHIATR, V10, P1
   Chadwick A, 2012, INT J MENT HEALTH NU, V21, P211, DOI 10.1111/j.1447-0349.2011.00807.x
   Chwastiak LA, 2015, LANCET PSYCHIAT, V2, P465, DOI 10.1016/S2215-0366(15)00105-4
   Courtney M., 2010, Using evidence to guide nursing practice, V2nd
   De Hert M, 2009, EUR PSYCHIAT, V24, P412, DOI 10.1016/j.eurpsy.2009.01.005
   Hert M, 2012, NAT REV ENDOCRINOL, V8, P114, DOI 10.1038/nrendo.2011.156
   Ehrlich C, 2014, INT J MENT HEALTH NU, V23, P243, DOI 10.1111/inm.12050
   Ezell JM, 2013, J HEALTH CARE POOR U, V24, P1552, DOI 10.1353/hpu.2013.0158
   Happell B, 2016, INT J SOC PSYCHIATR, V62, P201, DOI 10.1177/0020764015621771
   Happell B, 2015, PERSPECT PSYCHIATR C, V51, P268, DOI 10.1111/ppc.12091
   Happell B, 2014, J CLIN NURS, V23, P1018, DOI 10.1111/jocn.12371
   Happell B, 2013, PERSPECT PSYCHIATR C, V49, P210, DOI 10.1111/j.1744-6163.2012.00351.x
   Happell Brenda, 2012, Issues Ment Health Nurs, V33, P752, DOI 10.3109/01612840.2012.708099
   Happell BM, 2013, AUST HEALTH REV, V37, P453, DOI 10.1071/AH13045
   Hasnain M, 2009, PRIM CARE DIABETES, V3, P5, DOI 10.1016/j.pcd.2008.10.005
   Heald A, 2010, EUR PSYCHIAT, V25, pS41, DOI 10.1016/S0924-9338(10)71706-5
   Heslop B., 2016, INT J MENT HEALTH NU, V25, P1
   Heslop KR, 2015, INT J MENT HEALTH AD, V13, P618, DOI 10.1007/s11469-015-9548-z
   Maj M, 2009, WORLD PSYCHIATRY, V8, P1
   Mangurian C, 2013, PSYCHIAT SERV, V64, P597, DOI 10.1176/appi.ps.002542012
   McKenna B., 2014, BMC PSYCHIATRY, V14, P1
   NICE, 2014, Psychosis and Schizophrenia in Adults: Prevention and Management (Clinical Guideline 178)
   Pallava A, 2012, NORD J PSYCHIAT, V66, P215, DOI 10.3109/08039488.2011.621977
   Pastore P, 2013, COMMUNITY MENT HLT J, V49, P172, DOI 10.1007/s10597-012-9521-2
   Pérez-Iglesias R, 2014, INT J NEUROPSYCHOPH, V17, P41, DOI 10.1017/S1461145713001053
   Reilly S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036468
   Robson D, 2013, INT J MENT HEALTH NU, V22, P409, DOI 10.1111/j.1447-0349.2012.00883.x
   Robson D, 2012, INT J NURS STUD, V49, P72, DOI 10.1016/j.ijnurstu.2011.07.011
   Saloojee S., 2014, BMC PSYCHIATRY, V14, P1
   Snowball K., 2010, OPERATIONAL DIRECTIV
   Stanley S, 2010, CLIN GUIDELINES PHYS
   Stanley SH, 2011, AUST NZ J PSYCHIAT, V45, P824, DOI 10.3109/00048674.2011.614591
   Usher K, 2006, J PSYCHIATR MENT HLT, V13, P730, DOI 10.1111/j.1365-2850.2006.01026.x
   Vasudev Kamini, 2010, Ment Health Fam Med, V7, P115
   Waterreus AJ, 2009, MED J AUSTRALIA, V190, P185, DOI 10.5694/j.1326-5377.2009.tb02344.x
   Wolff A., 2009, MED J AUSTR BOOKS
   Wynaden D, 2016, INT J MENT HEALTH NU, V25, P516, DOI 10.1111/inm.12242
   Wynaden D, 2016, INT J MENT HEALTH NU, V25, P99, DOI 10.1111/inm.12207
NR 42
TC 17
Z9 18
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD FEB
PY 2018
VL 27
IS 1
BP 196
EP 203
DI 10.1111/inm.12309
PG 8
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA FS3XF
UT WOS:000419717100019
PM 28093900
DA 2025-06-11
ER

PT J
AU Adebajo, SB
   Adebiyi, R
   Chama, J
   Bello, S
   Ononaku, U
   Aka, A
   Lai, SH
   Baral, SD
   Dyer, TV
   Crowell, TA
   Nowak, RG
   Charurat, M
AF Adebajo, Sylvia B. B.
   Adebiyi, Ruxton
   Chama, John
   Bello, Segun
   Ononaku, Uche
   Aka, Abayomi
   Lai, Shenghan
   Baral, Stefan D. D.
   Dyer, Typhanye V. V.
   Crowell, Trevor A. A.
   Nowak, Rebecca G. G.
   Charurat, Man
CA TRUST RV368 Study Grp
TI Depression and Sexual Stigma Are Associated With Cardiometabolic Risk
   Among Sexual and Gender Minorities Living With HIV in Nigeria
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Article
DE sexual and gender minorities living with HIV; sexual stigma; depression;
   cardiometabolic diseases; syndemics; Nigeria
ID SUB-SAHARAN AFRICA; METABOLIC SYNDROME; MEN; PREVALENCE; DISEASE;
   HEALTH; DISCRIMINATION; INFLAMMATION; INFECTIONS; DEFINITION
AB Background:People living with HIV are vulnerable to cardiometabolic diseases. We assessed the prevalence of cardiometabolic risk factors (CMRF) and associations with sexual stigma and depression among sexual and gender minorities (SGM) in Abuja and Lagos, Nigeria.Methods:The TRUST/RV368 study enrolled SGM between March 2013 and February 2020. Participants were assessed for depression, sexual stigma, and CMRF. Robust multinomial logistic regression was used to estimate adjusted odds ratio (aORs) and 95% confidence intervals (CIs) for associations of depression, sexual stigma, and other factors with increasing numbers of CMRF.Results:Among 761 SGM, the mean age was 25.0 +/- 6.0 years; 580 (76%) identified as cisgender men, 641 (84%) had >= 1 CMRF, 355 (47%) had mild-severe depression, and 405 (53%) reported moderate-high sexual stigma. Compared with individuals without depression, those with mild (aOR 8.28; 95% CI: 4.18 to 16.40) or moderate-severe depression (aOR 41.69; 95% CI: 9.60 to 181.04) were more likely to have 3-5 CMRF. Individuals with medium (aOR 3.17; 95% CI: 1.79 to 5.61) and high sexual stigma (aOR 14.42; 95% CI: 2.88 to 72.29) compared with those with low sexual stigma were more likely to have 3-5 CMRF. Participants age 25-34 years were less likely to have 3-5 CMRF (aOR 0.41; 95% CI: 0.23 to 0.73) compared with participants age younger than 25 years.Conclusion:CMRF increased with severity of depression and sexual stigma, potentially predisposing SGM living with HIV to cardiometabolic diseases. Integrating interventions that address depression and sexual stigma in HIV care programs for SGM may improve cardiometabolic outcomes.
C1 [Adebajo, Sylvia B. B.; Adebiyi, Ruxton; Chama, John; Bello, Segun] Univ Maryland Baltimore, Ctr Int Hlth Educ Biosecur, 129 Yakubu Gowon Way, Abuja, Nigeria.
   [Ononaku, Uche] Inst Human Virol, Abuja, Nigeria.
   [Aka, Abayomi] ICARH, Abuja, Nigeria.
   [Lai, Shenghan; Nowak, Rebecca G. G.; Charurat, Man] Univ Maryland, Inst Human Virol, Sch Med, Baltimore, MD USA.
   [Baral, Stefan D. D.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
   [Dyer, Typhanye V. V.] Univ Maryland, Sch Publ Hlth, College Pk, MD USA.
   [Crowell, Trevor A. A.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
   [Crowell, Trevor A. A.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
   [Charurat, Man] Univ Maryland, Ctr Int Hlth Educ Biosecur, Sch Med, Baltimore, MD USA.
C3 University System of Maryland; University of Maryland Baltimore; Johns
   Hopkins University; Johns Hopkins Bloomberg School of Public Health;
   University System of Maryland; University of Maryland College Park;
   Henry M. Jackson Foundation for the Advancement of Military Medicine,
   Inc; United States Department of Defense; United States Army; Walter
   Reed Army Institute of Research (WRAIR); University System of Maryland;
   University of Maryland Baltimore
RP Adebajo, SB (corresponding author), Univ Maryland Baltimore, Ctr Int Hlth Educ Biosecur, 129 Yakubu Gowon Way, Abuja, Nigeria.
EM SAdebajo@mgic.umaryland.edu; ARuxton@mgic.umaryland.edu;
   JChama@mgic.umaryland.edu; drsegunbello@yahoo.com; uche.trust@gmail.com;
   aaka@icarh.org; SLai@ihv.umaryland.edu; sbaral@jhu.edu;
   typhanye@umd.edu; tcrowell@hivresearch.org; RNowak@ihv.umaryland.edu;
   MCharurat@ihv.umaryland.edu
RI Adebiyi, Ruxton/GLV-2986-2022; Crowell, Trevor/W-3904-2019
OI Adebajo, Sylvia/0000-0002-5933-8044; Adebiyi, Ruxton/0000-0002-1398-7057
FU Henry M. Jackson Foundation for the Advancement of Military Medicine,
   Inc; U.S. Department of Defense [W81XWH-11-2-0174, W81XWH-18-2-0040];
   National Institutes of Health [R01 MH099001, R01 AI120913, R01 MH110358,
   K07CA225403, R01HL165686]; Fogarty Epidemiology Research Training for
   Public Health Impact in Nigeria program [D43TW010051]; Institute for
   Human Virology-Nigeria [NU2GGH002099]; Department of Health and Human
   Services/Centers for Disease Control and Prevention; Global AIDS Program
FX Supported by cooperative agreements between the Henry M. Jackson
   Foundation for the Advancement of Military Medicine, Inc., and the U.S.
   Department of Defense [W81XWH-11-2-0174, W81XWH-18-2-0040]; the National
   Institutes of Health [R01 MH099001, R01 AI120913, R01 MH110358,
   K07CA225403, and R01HL165686]; Fogarty Epidemiology Research Training
   for Public Health Impact in Nigeria program [D43TW010051]; and the
   President's Emergency Plan for AIDS Relief through a cooperative
   agreement between the Department of Health and Human Services/Centers
   for Disease Control and Prevention, Global AIDS Program, and the
   Institute for Human Virology-Nigeria [NU2GGH002099].
CR Ake JA, 2019, CLIN INFECT DIS, V69, P639, DOI 10.1093/cid/ciy981
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Anderson AM, 2015, AIDS CARE, V27, P63, DOI 10.1080/09540121.2014.951597
   [Anonymous], 1995, PHYS STATUS USE INTE
   Armah KA, 2012, CLIN INFECT DIS, V55, P126, DOI 10.1093/cid/cis406
   Baral SD, 2015, JAIDS-J ACQ IMM DEF, V68, pS107, DOI 10.1097/QAI.0000000000000438
   Bavinger C, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059551
   Castro JP, 2003, CURR HYPERTENS REP, V5, P393, DOI 10.1007/s11906-003-0085-y
   Cezaretto A, 2015, J AFFECT DISORDERS, V174, P516, DOI 10.1016/j.jad.2014.12.037
   Charurat ME, 2015, JAIDS-J ACQ IMM DEF, V68, pS114, DOI 10.1097/QAI.0000000000000439
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   Crowell TA, 2017, J INT AIDS SOC, V20, DOI 10.7448/IAS.20.01.21489
   Daly M, 2017, PSYCHOL SCI, V28, P872, DOI 10.1177/0956797617696311
   Deeks SG, 2013, IMMUNITY, V39, P633, DOI 10.1016/j.immuni.2013.10.001
   Deeks SG, 2009, BMJ-BRIT MED J, V338, DOI 10.1136/bmj.a3172
   Dillon DG, 2013, INT J EPIDEMIOL, V42, P1754, DOI [10.1093/ije/dyt198, 10.1093/ije/dyw312]
   Dimala CA, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0201404
   Ditmars HL, 2022, PSYCHOL MED, V52, P3007, DOI 10.1017/S003329172000505X
   Dolezsar CM, 2014, HEALTH PSYCHOL, V33, P20, DOI 10.1037/a0033718
   Ehrlich AM, 2019, AM FAM PHYSICIAN, V100, P72
   Fu HL, 2020, J AFFECT DISORDERS, V277, P192, DOI 10.1016/j.jad.2020.08.011
   Gelaye B, 2015, DIABETES METAB SYND, V9, P183, DOI 10.1016/j.dsx.2014.05.003
   Gronholm PC, 2017, PSYCHOL MED, V47, P1867, DOI 10.1017/S0033291717000344
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hui L, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-08539-0
   Information NCfB, 2017, HIGH CHOL OV
   Javed A, 2021, ASIAN J PSYCHIATR, V58, DOI 10.1016/j.ajp.2021.102601
   Karanchi H., 2021, STATPEARLS
   Keshinro B, 2016, J INT AIDS SOC, V19, DOI 10.7448/IAS.19.1.21270
   Khawaja AA, 2020, CIRC RES, V127, P1365, DOI 10.1161/CIRCRESAHA.119.316477
   Levis, 2019, BMJ-BRIT MED J, V365, DOI 10.1136/bmj.l1781
   Major B, 2012, SOC PSYCHOL PERS SCI, V3, P651, DOI 10.1177/1948550611434400
   Martin Allison, 2009, Expert Rev Clin Pharmacol, V2, P381, DOI 10.1586/ecp.09.11
   Matheson K., 2008, The Open Psychology Journal, V1, P1
   Mbunkah HA, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-92
   Nowak RG, 2019, JAIDS-J ACQ IMM DEF, V80, P444, DOI [10.1097/QAI.0000000000001934, 10.1097/qai.0000000000001934]
   Nowak RG, 2016, SEX TRANSM DIS, V43, P243, DOI 10.1097/OLQ.0000000000000431
   Oguoma VM, 2015, PUBLIC HEALTH, V129, P413, DOI 10.1016/j.puhe.2015.01.017
   Oladapo OO, 2010, CARDIOVASC J AFR, V21, P26
   Patel P, 2018, AIDS, V32, pS5, DOI 10.1097/QAD.0000000000001888
   Patterson SL, 2021, CIRCULATION, V143, DOI 10.1161/circ.143.suppl_1.P192
   Quinn KG, 2020, CURR HIV-AIDS REP, V17, P290, DOI 10.1007/s11904-020-00510-5
   Rodriguez-Hart C, 2018, AIDS BEHAV, V22, P3905, DOI 10.1007/s10461-018-2191-5
   Rodriguez-Hart C, 2018, AIDS BEHAV, V22, P1662, DOI 10.1007/s10461-017-1982-4
   Rodriguez-Hart C, 2017, AIDS, V31, P2415, DOI [10.1097/QAD.0000000000001637, 10.1097/qad.0000000000001637]
   Rosati F, 2021, FRONT NEUROSCI-SWITZ, V15, DOI 10.3389/fnins.2021.619171
   Rozanski A, 1999, CIRCULATION, V99, P2192, DOI 10.1161/01.CIR.99.16.2192
   Rueda S, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2016-011453
   Sartorious Norman, 2013, Shanghai Arch Psychiatry, V25, P68, DOI 10.3969/j.issn.1002-0829.2013.02.002
   Secor AM, 2015, AIDS, V29, pS251, DOI 10.1097/QAD.0000000000000846
   Shao MJ, 2020, PSYCHIAT RES, V285, DOI 10.1016/j.psychres.2020.112802
   Srivastava AK, 2012, INDIAN J PHARMACOL, V44, P155, DOI 10.4103/0253-7613.93579
   Stahlman S, 2016, SEX TRANSM INFECT, V92, P292, DOI 10.1136/sextrans-2015-052184
   Stockton MA, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0199602
   Sutin AR, 2014, OBESITY, V22, P1959, DOI 10.1002/oby.20789
   Tang BW, 2020, DIABETOLOGIA, V63, P1305, DOI 10.1007/s00125-020-05131-6
   Tomiyama AJ, 2018, BMC MED, V16, DOI 10.1186/s12916-018-1116-5
   Trickey A, 2017, LANCET HIV, V4, pE349, DOI 10.1016/S2352-3018(17)30066-8
   Tucker A, 2014, AIDS CARE, V26, P882, DOI 10.1080/09540121.2013.859652
   Ulasi II, 2010, BMC HEALTH SERV RES, V10, DOI 10.1186/1472-6963-10-71
   Venables E, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0164634
   Wakabayashi I, 2018, OBES RES CLIN PRACT, V12, P372, DOI 10.1016/j.orcp.2016.12.008
   WHO, 2011, Global Status Report on Noncommunicable Diseases 2010, P9
NR 64
TC 3
Z9 3
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1525-4135
EI 1077-9450
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD JAN 1
PY 2023
VL 92
IS 1
BP 50
EP 58
DI 10.1097/QAI.0000000000003096
PG 9
WC Immunology; Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Infectious Diseases
GA 6Z0EU
UT WOS:000897457800009
PM 36150037
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Mommersteeg, PMC
   Pot, I
   Aarnoudse, W
   Denollet, J
   Widdershoven, JW
AF Mommersteeg, Paula M. C.
   Pot, Irene
   Aarnoudse, Wilbert
   Denollet, Johan
   Widdershoven, Jos W.
TI Type D personality and patient-perceived health in nonsignificant
   coronary artery disease: the TWeesteden mIld STenosis (TWIST) study
SO QUALITY OF LIFE RESEARCH
LA English
DT Article
DE Mild stenosis; Nonsignificant coronary artery disease; Type D
   personality; Chest pain; Health status; General distress
ID RISK-FACTORS; NEGATIVE AFFECTIVITY; METABOLIC SYNDROME; SOCIAL
   INHIBITION; DEPRESSION SCALE; HOSPITAL ANXIETY; NATIONAL-HEART;
   CHEST-PAIN; ANGINA; PREVALENCE
AB To examine whether Type D-distressed-personality is independently associated with patient reported health outcomes, such as chest pain, health status and emotional distress, in patients with angiographically nonsignificant coronary abnormalities. Psychosocial factors, such as Type D personality, are risk factors for established coronary artery disease (CAD), but are unknown for patients with non-obstructive CAD.
   A total of 273 patients (62 years, SD 10, 49 % male) participated in the cross-sectional part of the 'TWeesteden mIld STenosis' study. Inclusion was based on coronary angiography or CT-scan. Type D personality was examined in relation to chest pain, disease-specific (Seattle Angina Questionnaire) and generic health status (Short Form 12), and emotional distress (Hospital Anxiety and Depression Scale, Fatigue), adjusted for confounders and potential explanatory lifestyle factors.
   Patients with Type D personality (30 %) had an increased prevalence of chest pain (57 vs. 40 %). When adjusted for confounder's age, gender, comorbidity, and medication use, Type D personality was significantly associated with increased chest pain, poorer disease-specific and generic health status and increased emotional distress. After further adjustment for explanatory lifestyle factors such as smoking, physical activity, and metabolic syndrome, Type D personality was associated with worse disease perception, lower treatment satisfaction, poor physical and mental health status, and higher emotional distress, but no longer with chest pain, angina stability, or physical limitations.
   Type D personality was significantly associated with poor patient-perceived symptoms in patients with mild coronary abnormalities, which can be hypothesized to be detrimental in the long run.
C1 [Mommersteeg, Paula M. C.; Pot, Irene; Denollet, Johan] Tilburg Univ, Dept Med & Clin Psychol, CoRPS, Ctr Res Psychol Somat Dis, Warandelaan 2,POB 90153, NL-5000 LE Tilburg, Netherlands.
   [Aarnoudse, Wilbert; Widdershoven, Jos W.] TweeSteden Hosp, Dept Cardiol, NL-5042 AD Tilburg, Netherlands.
C3 Tilburg University; Elisabeth-TweeSteden Ziekenhuis (ETZ)
RP Mommersteeg, PMC (corresponding author), Tilburg Univ, Dept Med & Clin Psychol, CoRPS, Ctr Res Psychol Somat Dis, Warandelaan 2,POB 90153, NL-5000 LE Tilburg, Netherlands.
EM P.M.C.Mommersteeg@tilburguniversity.edu
RI Mommersteeg, Paula/AAB-7801-2019
FU BIOTRONIK Nederland B.V.
FX The authors would like to thank the staff and employees of the
   TweeSteden Hospital Cardiology, laboratory, CAG and CT units. The
   authors would like to thank Tilburg University research assistants
   Sylvie Teurlings, Marjanne Bakker, Fleur Kuipers, Ferry van Eekelen, and
   Laura G. A. M. van Doornmalen for their contribution in the data
   collection of this study. P. M. C. M. received a travel grant of 250
   euro of BIOTRONIK Nederland B.V.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Ambrose JA, 2010, AM J MED, V123, P10, DOI 10.1016/j.amjmed.2009.07.019
   Bjelland I, 2002, J PSYCHOSOM RES, V52, P69, DOI 10.1016/S0022-3999(01)00296-3
   Bugiardini R, 2005, JAMA-J AM MED ASSOC, V293, P477, DOI 10.1001/jama.293.4.477
   Bugiardini R, 2007, PLOS MED, V4, P252, DOI 10.1371/journal.pmed.0040012
   Bugiardini R, 2006, ARCH INTERN MED, V166, P1391, DOI 10.1001/archinte.166.13.1391
   Cassar A, 2009, MAYO CLIN PROC, V84, P1130, DOI 10.4065/mcp.2009.0391
   Denollet J, 2005, PSYCHOSOM MED, V67, P89, DOI 10.1097/01.psy.0000149256.81953.49
   Denollet J, 2010, CIRC-CARDIOVASC QUAL, V3, P546, DOI 10.1161/CIRCOUTCOMES.109.934406
   Faletra FF, 2009, HEART, V95, P1265, DOI 10.1136/hrt.2009.167098
   Grande G, 2012, ANN BEHAV MED, V43, P299, DOI 10.1007/s12160-011-9339-0
   Halligan S, 2004, PROG CARDIOVASC DIS, V46, P453, DOI 10.1016/j.pcad.2003.12.003
   Hausteiner C, 2010, PSYCHOSOM MED, V72, P163, DOI 10.1097/PSY.0b013e3181cb8bae
   Johnson BD, 2006, EUR HEART J, V27, P1408, DOI 10.1093/eurheartj/ehl040
   Johnson BD, 2004, CIRCULATION, V109, P2993, DOI 10.1161/01.CIR.0000130642.79868.B2
   Ketterer MW, 2008, PSYCHOSOMATICS, V49, P230, DOI 10.1176/appi.psy.49.3.230
   Khot UN, 2003, JAMA-J AM MED ASSOC, V290, P898, DOI 10.1001/jama.290.7.898
   Krumholz HM, 2005, CIRCULATION, V111, P3158, DOI 10.1161/CIRCULATIONAHA.105.536102
   Kupper N, 2013, INT J CARDIOL, V166, P327, DOI 10.1016/j.ijcard.2011.10.084
   Mathers C, 2008, GLOBAL BURDEN OF DISEASE: 2004 UPDATE, P1
   Michielsen HJ, 2003, J PSYCHOSOM RES, V54, P345, DOI 10.1016/S0022-3999(02)00392-6
   Mols F, 2010, HEART, V96, P30, DOI 10.1136/hrt.2009.170357
   Mols F, 2009, QUAL LIFE RES, V18, P403, DOI 10.1007/s11136-009-9455-5
   Mommersteeg PMC, 2012, J PSYCHOSOM RES, V73, P326, DOI 10.1016/j.jpsychores.2012.08.019
   Mommersteeg PMC, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-714
   Mommersteeg PMC, 2009, AM HEART J, V157, P208, DOI 10.1016/j.ahj.2008.09.020
   Peduzzi P, 1996, J CLIN EPIDEMIOL, V49, P1373, DOI 10.1016/S0895-4356(96)00236-3
   Perk J, 2012, EUR HEART J, V33, P1635, DOI 10.1093/eurheartj/ehs092
   Rozanski A, 2005, J AM COLL CARDIOL, V45, P637, DOI 10.1016/j.jacc.2004.12.005
   Smith TW, 2011, PSYCHOSOM MED, V73, P528, DOI 10.1097/PSY.0b013e31822e095e
   Spertus J, 2001, AM HEART J, V142, P745, DOI 10.1067/mhj.2001.119135
   SPERTUS JA, 1995, J AM COLL CARDIOL, V25, P333, DOI 10.1016/0735-1097(94)00397-9
   Svansdottir E, 2012, J BEHAV MED, V35, P155, DOI 10.1007/s10865-011-9337-5
   Timmis AD, 2007, HEART, V93, P786, DOI 10.1136/hrt.2006.103119
   Tulloch H., 2008, CURRENT ISSUES CARDI, V16, P2
   Ulvik B, 2008, HEART LUNG, V37, P286, DOI 10.1016/j.hrtlng.2007.08.001
   Ware JE, 1996, MED CARE, V34, P220, DOI 10.1097/00005650-199603000-00003
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 38
TC 12
Z9 15
U1 0
U2 6
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-9343
EI 1573-2649
J9 QUAL LIFE RES
JI Qual. Life Res.
PD OCT
PY 2013
VL 22
IS 8
BP 2041
EP 2050
DI 10.1007/s11136-012-0340-2
PG 10
WC Health Care Sciences & Services; Health Policy & Services; Public,
   Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA 253HC
UT WOS:000327073900016
PM 23263915
DA 2025-06-11
ER

PT J
AU Armato, J
   Defronzo, RA
   Abdul-Ghani, M
   Ruby, R
AF Armato, John
   Defronzo, Ralph A.
   Abdul-Ghani, Muhammad
   Ruby, Ron
TI Pre-Prediabetes: Insulin Resistance Is Associated With Cardiometabolic
   Risk in Nonobese Patients (STOP DIABETES)
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE insulin resistance; prediabetes; cardiometabolic risk
ID ENDOPLASMIC-RETICULUM STRESS; METABOLIC SYNDROME; GLUCOSE-TOLERANCE;
   ATHEROSCLEROSIS; DIAGNOSIS; HYPERINSULINEMIA; SENSITIVITY; INTOLERANCE;
   OBESITY; NIDDM
AB Context Prior studies have demonstrated glycemic and cardiometabolic risk in the prediabetic state.Objective This work aims to examine if insulin resistance (IR) is associated with markers of glycemic, cardiometabolic, and atherosclerotic risk in nonobese, nonprediabetic individuals compared to insulin-sensitive (IS) individuals matched for body mass index (BMI), sex, and age.Methods Of 1860 patients from the STOP DIABETES study, 624 had normal fasting plasma glucose, BMI less than 30, and glycated hemoglobin A1c (HbA1c) less than 5.7%. All received an oral glucose tolerance test. Insulin sensitivity was quantitated using the Matsuda index: less than the 25th percentile equals IR (n = 151) and 25th percentile or greater equals IS (n = 473). Measures of dysglycemia and cardiometabolic risk were compared between IR individuals (n = 151) and a subset of IS individuals who were matched for BMI, sex, and age (n = 151). Carotid intima media thickness and carotid plaque were measured in 65 IR and 76 IS individuals.Results Compared to matched IS patients, IR nonobese individuals demonstrated increased indicators of glycemic and cardiometabolic risk, including increased 60-minute plasma glucose and percentage of patients with 60-minute plasma glucose greater than 155 mg/dL; increased 120-minute plasma glucose; unrecognized impaired glucose tolerance and type 2 diabetes, decreased disposition index; increased systolic and diastolic blood pressure; elevated plasma triglycerides (TGs); reduced high-density lipoprotein (HDL) cholesterol; increased TGs/HDL ratio, and high-sensitivity C-reactive protein. The presence, size, and number of carotid plaques was greater in the IR group.Conclusion Approximately 1 in 4 nonobese patients in this population with normal fasting glucose and HbA1c were IR. In these nonobese participants, IR was associated with multiple indicators of dysglycemia and cardiometabolic risk.
C1 [Armato, John; Ruby, Ron] Providence Little Co Mary Cardiometab Ctr, Providence Med Associates, Torrance, CA 90503 USA.
   [Defronzo, Ralph A.; Abdul-Ghani, Muhammad] Univ Texas Hlth Sci Ctr San Antonio, Diabet Div, San Antonio, TX 78207 USA.
   [Defronzo, Ralph A.; Abdul-Ghani, Muhammad] Texas Diabet Inst, San Antonio, TX 78207 USA.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio
RP Armato, J (corresponding author), Providence Hlth & Serv, 520 N Prospect S200, Redondo Beach, CA 90277 USA.
EM dr.armato@gmail.com
OI DeFronzo, Ralph/0000-0002-8581-6273
CR Abdul-Ghani MA, 2006, DIABETES, V55, P1430, DOI 10.2337/db05-1200
   Abdul-Ghani MA, 2008, DIABETES CARE, V31, P1650, DOI 10.2337/dc08-0225
   [Anonymous], 2015, DIABETES CARE, V38, pS8, DOI 10.2337/dc15-S005
   Armato JP, 2018, LANCET DIABETES ENDO, V6, P781, DOI 10.1016/S2213-8587(18)30234-1
   Bansal N, 2015, WORLD J DIABETES, V6, P296, DOI 10.4239/wjd.v6.i2.296
   Bergman M, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.752329
   Bonora E, 2003, DIABETES CARE, V26, P1251, DOI 10.2337/diacare.26.4.1251
   Bressler P, 1996, DIABETOLOGIA, V39, P1345, DOI 10.1007/s001250050581
   Camacho JE, 2016, ENDOCR PRACT, V22, P1288, DOI 10.4158/EP161267.OR
   DeFronzo RA, 2010, DIABETOLOGIA, V53, P1270, DOI 10.1007/s00125-010-1684-1
   DEFRONZO RA, 1991, DIABETES CARE, V14, P173, DOI 10.2337/diacare.14.3.173
   DEFRONZO RA, 1979, DIABETES, V28, P1095, DOI 10.2337/diab.28.12.1095
   DeFronzo RA, 2009, DIABETES, V58, P773, DOI 10.2337/db09-9028
   Di Pino A, 2019, ENDOCR REV, V40, P1447, DOI 10.1210/er.2018-00141
   Eizirik DL, 2008, ENDOCR REV, V29, P42, DOI 10.1210/er.2007-0015
   Ferrannini E, 2005, J CLIN ENDOCR METAB, V90, P493, DOI 10.1210/jc.2004-1133
   Ferrannini E, 2003, DIABETOLOGIA, V46, P1211, DOI 10.1007/s00125-003-1169-6
   Gast KB, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0052036
   Gastaldelli A, 2004, DIABETOLOGIA, V47, P31, DOI 10.1007/s00125-003-1263-9
   Gepner AD, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.116.005179
   GULLI G, 1992, DIABETES, V41, P1575, DOI 10.2337/diabetes.41.12.1575
   Johri AM, 2020, J AM SOC ECHOCARDIOG, V33, P917, DOI 10.1016/j.echo.2020.04.021
   Kahn BB, 2000, J CLIN INVEST, V106, P473, DOI 10.1172/JCI10842
   Kernan WN, 2016, NEW ENGL J MED, V374, P1321, DOI 10.1056/NEJMoa1506930
   Khokhar Aditi, 2017, Clin Diabetes, V35, P133, DOI 10.2337/cd16-0037
   Laichuthai N., 2021, J ENDOCRINOL SCI, V3, P16, DOI [10.29245/2767-5157/2021/1.1115, DOI 10.29245/2767-5157/2021/1.1115]
   Laybutt DR, 2007, DIABETOLOGIA, V50, P752, DOI 10.1007/s00125-006-0590-z
   Matsuda M, 1999, DIABETES CARE, V22, P1462, DOI 10.2337/diacare.22.9.1462
   Meigs JB, 2000, JAMA-J AM MED ASSOC, V283, P221, DOI 10.1001/jama.283.2.221
   Owei I, 2017, BMJ OPEN DIAB RES CA, V5, DOI 10.1136/bmjdrc-2017-000415
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Rossello X, 2021, J AM COLL CARDIOL, V77, P2777, DOI 10.1016/j.jacc.2021.03.335
   Stern MP, 2004, DIABETES CARE, V27, P2676, DOI 10.2337/diacare.27.11.2676
   WARRAM JH, 1990, ANN INTERN MED, V113, P909, DOI 10.7326/0003-4819-113-12-909
NR 34
TC 0
Z9 0
U1 3
U2 4
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD MAY
PY 2025
VL 110
IS 5
BP e1481
EP e1487
DI 10.1210/clinem/dgae540
EA AUG 2024
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 1TR3H
UT WOS:001291636000001
PM 39109850
OA Bronze
DA 2025-06-11
ER

PT J
AU Naicker, K
   Manuel, D
   Overland, S
   Skogen, JC
   Johnson, JA
   Sivertsen, B
   Colman, I
AF Naicker, Kiyuri
   Manuel, Douglas
   Overland, Simon
   Skogen, Jens C.
   Johnson, Jeffrey A.
   Sivertsen, Borge
   Colman, Ian
TI Population attributable fractions for Type 2 diabetes: an examination of
   multiple risk factors including symptoms of depression and anxiety
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Type 2 diabetes; Attributable fractions; Depression; Anxiety; Metabolic
   risk
ID METABOLIC SYNDROME; HEART-DISEASE; OBESITY; ASSOCIATION; MORTALITY;
   PROFILE; LIFE
AB BackgroundPopulation attributable fractions (PAFs) are frequently used to quantify the proportion of Type 2 diabetes cases due to single risk factors, an approach which may result in an overestimation of their individual contributions. This study aimed to examine Type 2 diabetes incidence associated with multiple risk factor combinations, including the metabolic syndrome, behavioural factors, and specifically, depression and anxiety.MethodsUsing data from the population-based HUNT cohort, we examined incident diabetes in 36,161 Norwegian adults from 1995 to 2008. PAFs were calculated using Miettinen's case-based formula, using relative risks estimated from multivariate regression models.ResultsOverall, the studied risk factors accounted for 50.5% of new diabetes cases (78.2% in men and 47.0% in women). Individuals exposed to both behavioural and metabolic factors were at highest risk of diabetes onset (PAF=22.9%). Baseline anxiety and depression contributed a further 13.6% of new cases to this combination. Men appeared to be particularly vulnerable to the interaction between metabolic, behavioural and psychological risk factors.ConclusionThis study highlights the importance of risk factor clustering in diabetes onset, and is the first that we know of to quantify the excess fraction of incident diabetes associated with psychological risk factor interactions.
C1 [Naicker, Kiyuri; Colman, Ian] Univ Ottawa, Sch Epidemiol & Publ Hlth, 600 Peter Morand Cres,Room 308C, Ottawa, ON K1G 5Z3, Canada.
   [Manuel, Douglas] Ottawa Hosp Res Inst, Ottawa, ON, Canada.
   [Overland, Simon; Skogen, Jens C.; Sivertsen, Borge] Norwegian Inst Publ Hlth, Dept Hlth Promot, Bergen, Norway.
   [Overland, Simon] Univ Bergen, Dept Psychosocial Sci, Bergen, Norway.
   [Skogen, Jens C.] Stavanger Univ Hosp, Ctr Alcohol & Drug Res, Stavanger, Norway.
   [Johnson, Jeffrey A.] Univ Alberta, Sch Publ Hlth, Edmonton, AB, Canada.
   [Sivertsen, Borge] Helse Fonna HF, Dept Res & Innovat, Haugesund, Norway.
   [Sivertsen, Borge] Uni Res Hlth, Reg Ctr Child & Youth Mental Hlth & Child Welf, Bergen, Norway.
C3 University of Ottawa; University of Ottawa; Ottawa Hospital Research
   Institute; Norwegian Institute of Public Health (NIPH); University of
   Bergen; Stavanger University Hospital; University of Alberta
RP Colman, I (corresponding author), Univ Ottawa, Sch Epidemiol & Publ Hlth, 600 Peter Morand Cres,Room 308C, Ottawa, ON K1G 5Z3, Canada.
EM icolman@uottawa.ca
RI Colman, Ian/AFK-4708-2022; Skogen, Jens Christoffer/LPR-0817-2024;
   Øverland, Simon/ABF-1289-2020; Sivertsen, Borge/JRY-4994-2023; Manuel,
   Doug/D-7100-2014
OI Overland, Simon/0000-0001-6967-9355; Sivertsen,
   Borge/0000-0003-4654-9296; Manuel, Doug/0000-0003-0912-0845; Colman,
   Ian/0000-0001-5924-0277; Skogen, Jens Christoffer/0000-0003-0722-5440
FU Canada Research Chairs program; Ontario Mental Health Foundation;
   Alberta Innovates Health Solutions
FX This work was supported in part by funding from the Canada Research
   Chairs program for IC, and by an Ontario Mental Health Foundation
   doctoral award held by KN. JAJ holds a Senior Health Scholar award from
   Alberta Innovates Health Solutions.
CR Al Tunaiji H, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-469
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   [Anonymous], 2013, DIAGNOSTIC STAT MANU
   [Anonymous], 2015, IDF Diabetes Atlas, V7
   [Anonymous], 2010, GLOB REC PHYS ACT HL
   Chang MH, 2001, J CLIN EPIDEMIOL, V54, P634, DOI 10.1016/S0895-4356(00)00343-7
   Cheng AYY, 2013, CAN J DIABETES, V37, pS1, DOI 10.1016/j.jcjd.2013.01.009
   Cherrington A, 2010, J BEHAV MED, V33, P81, DOI 10.1007/s10865-009-9233-4
   Cosgrove MP, 2008, OCCUP MED-OXFORD, V58, P7, DOI 10.1093/occmed/kqm105
   Coventry P, 2015, BMJ-BRIT MED J, V350, DOI 10.1136/bmj.h638
   Demakakos P, 2014, PSYCHOSOM MED, V76, P555, DOI 10.1097/PSY.0000000000000082
   Flegal KM, 2015, ANN EPIDEMIOL, V25, P201, DOI 10.1016/j.annepidem.2014.11.010
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   GENEST J, 1995, AM J CARDIOL, V76, pA8
   Goodpaster BH, 2005, ARCH INTERN MED, V165, P777, DOI 10.1001/archinte.165.7.777
   Hanley JA, 2001, J EPIDEMIOL COMMUN H, V55, P508, DOI 10.1136/jech.55.7.508
   Harrell FE, 2015, SPRINGER SER STAT, P13, DOI 10.1007/978-3-319-19425-7_2
   Hernán MA, 2008, INT J OBESITY, V32, pS8, DOI 10.1038/ijo.2008.82
   Hildrum B, 2007, J EPIDEMIOL COMMUN H, V61, P53, DOI 10.1136/jech.2005.044966
   Hirschfeld Robert M. A., 2001, Prim Care Companion J Clin Psychiatry, V3, P244
   Hou RH, 2012, HUM PSYCHOPHARM CLIN, V27, P6, DOI 10.1002/hup.1259
   HULLEY SB, 1988, DRUGS, V36, P1, DOI 10.2165/00003495-198800363-00003
   Imamura F, 2015, BMJ-BRIT MED J, V351, DOI 10.1136/bmj.h3576
   Jousilahti P, 1995, J Cardiovasc Risk, V2, P63, DOI 10.1097/00043798-199502000-00010
   KANNEL WB, 1976, AM J CARDIOL, V38, P46, DOI 10.1016/0002-9149(76)90061-8
   Khambaty T, 2014, PSYCHOSOM MED, V76, P363, DOI 10.1097/PSY.0000000000000063
   Krokstad S, 2013, INT J EPIDEMIOL, V42, P968, DOI 10.1093/ije/dys095
   Laaksonen MA, 2010, EUR J EPIDEMIOL, V25, P115, DOI 10.1007/s10654-009-9405-0
   Langhammer A, 2012, BMC MED RES METHODOL, V12, DOI 10.1186/1471-2288-12-143
   LEVIN M L, 1953, Acta Unio Int Contra Cancrum, V9, P531
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Markowitz SM, 2011, PSYCHOSOMATICS, V52, P1, DOI 10.1016/j.psym.2010.11.007
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Moulton CD, 2015, LANCET DIABETES ENDO, V3, P461, DOI 10.1016/S2213-8587(15)00134-5
   Naicker K, 2017, DIABETES CARE, V40, P352, DOI 10.2337/dc16-2018
   Roshanaei-Moghaddam B, 2009, GEN HOSP PSYCHIAT, V31, P306, DOI 10.1016/j.genhosppsych.2009.04.002
   Royston P, 2004, STATA J, V4, P227, DOI 10.1177/1536867X0400400301
   Rubin RR, 2002, DIABETES-METAB RES, V18, P173, DOI 10.1002/dmrr.292
   Sandhu MS, 2007, NAT GENET, V39, P951, DOI 10.1038/ng2067
   Sogaard A.J., 2003, NORSK EPIDEMIOLOGI, V13, P279, DOI [DOI 10.5324/NJE.V13I2.296, 10.5324/nje.v13i2.296]
   Vogelzangs N, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.27
   Wang YF, 2005, AM J CLIN NUTR, V81, P555
   Wannamethee SG, 2001, DIABETES CARE, V24, P1590, DOI 10.2337/diacare.24.9.1590
   Will JC, 2001, INT J EPIDEMIOL, V30, P540, DOI 10.1093/ije/30.3.540
   WILLIS T, 1971, DIABETES MED ODYSSEY
   Young EA, 2004, BIOL PSYCHIAT, V56, P113, DOI 10.1016/j.biopsych.2004.03.017
NR 46
TC 10
Z9 10
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD NOV 22
PY 2018
VL 10
AR 84
DI 10.1186/s13098-018-0387-5
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HB4OC
UT WOS:000451032000001
PM 30479670
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tso, G
   Kumar, P
   Jayasooriya, T
   Kisely, S
   Siskind, D
AF Tso, Grace
   Kumar, Puja
   Jayasooriya, Thilini
   Kisely, Steve
   Siskind, Dan
TI Metabolic monitoring and management among clozapine users
SO AUSTRALASIAN PSYCHIATRY
LA English
DT Article
DE metabolic syndrome; clozapine; antipsychotic; psychosis; metabolic
   monitoring
ID DEFINITION
AB Objective: To assess, among clozapine users, the rates of monitoring, presence and treatment of metabolic syndrome and its components.
   Methods: A chart review was conducted of all clozapine users who were followed up in community mental health clinics at two Metro South Health Hospitals over a 1-year period. Metabolic syndrome was diagnosed according to the International Diabetes Federation criteria.
   Results: We included 251 clozapine users. Only 43.4% (109/251) had data collected for all five metabolic syndrome parameters. Among these people, 45.0% (49/109) met criteria for metabolic syndrome, while 61.2% (30/49) of those with metabolic syndrome were offered appropriate treatments. Correspondence with primary care providers occurred in only 18.7% (n = 47). Non-pharmacological interventions, such as motivational interviewing and education about healthy lifestyle alternatives, occurred in 49.8% (n = 125).
   Conclusions: There is growing awareness of the importance of metabolic monitoring, however, there remain specific gaps in the collaborative work among mental health services, primary care providers and clozapine users, to ensure appropriate physical health interventions.
C1 [Tso, Grace; Kumar, Puja; Jayasooriya, Thilini; Kisely, Steve; Siskind, Dan] Metro South Addict & Mental Hlth Serv, Psychiat, Brisbane, Qld, Australia.
   [Jayasooriya, Thilini] Dist Gen Hosp Trincomalee, Trincomalee, Sri Lanka.
   [Kisely, Steve; Siskind, Dan] Univ Queensland, Sch Med, Brisbane, Qld, Australia.
C3 University of Queensland
RP Tso, G (corresponding author), Princess Alexandra Hosp, Metro South Addict & Mental Hlth Serv, 199 Ipswich Rd, Woolloongabba, Qld 4102, Australia.
EM grace.tso@health.qld.gov.au
RI Kisely, Steve/B-4680-2012; Siskind, Dan/A-9812-2014
OI Siskind, Dan/0000-0002-2072-9216
CR Agid O, 2011, J CLIN PSYCHIAT, V72, P1439, DOI 10.4088/JCP.09m05785yel
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Brown S, 1997, BRIT J PSYCHIAT, V171, P502, DOI 10.1192/bjp.171.6.502
   Druss BG, 2002, MED CARE, V40, P129, DOI 10.1097/00005650-200202000-00007
   Forrester T, 2015, PHARMACOPSYCHIATRY, V48, P164, DOI 10.1055/s-0035-1554713
   Goldenberg R, 2013, CAN J DIABETES, V37, pS8, DOI 10.1016/j.jcjd.2013.01.011
   Lawrence D, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f2539
   Mayfield K, 2016, J PSYCHOPHARMACOL, V22, P1
   Mitchell AJ, 2012, PSYCHOL MED, V42, P125, DOI 10.1017/S003329171100105X
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Siskind D, 2016, BRIT J PSYCHIAT, V209, P387, DOI 10.1192/bjp.bp.115.177261
NR 11
TC 19
Z9 19
U1 0
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1039-8562
EI 1440-1665
J9 AUSTRALAS PSYCHIATRY
JI Australas. Psychiatry
PD FEB
PY 2017
VL 25
IS 1
BP 48
EP 52
DI 10.1177/1039856216665282
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EL8ZI
UT WOS:000394908500013
PM 27590080
DA 2025-06-11
ER

PT J
AU Alkazemi, D
   Egeland, GM
   Roberts, LJ
   Kubow, S
AF Alkazemi, Dalal
   Egeland, Grace M.
   Roberts, Lyman Jackson, II
   Kubow, Stan
TI Isoprostanes and isofurans as non-traditional risk factors for
   cardiovascular disease among Canadian Inuit
SO FREE RADICAL RESEARCH
LA English
DT Article
DE isoprostanes; isofurans; oxidative stress; CRP; Inuit; metabolic
   syndrome
ID HYPERTRIGLYCERIDEMIC-WAIST PHENOTYPE; OXIDATIVE STRESS; OXIDANT STRESS;
   METABOLIC-SYNDROME; LIPID-PEROXIDATION; BIOLOGICAL-FLUIDS; CIRCUMPOLAR
   INUIT; BLOOD-PRESSURE; TISSUE OXYGEN; HEALTH SURVEY
AB Objectives: The aim of the present study was to investigate the potential importance of oxidative stress, measured by isoprostanes-related compounds, as non-traditional risk factor for cardiovascular disease. We planned to examine the relationship between concentrations of plasma F-2- isoprostanes (F-2-IsoPs), isofurans (IsoFs), measures of obesity and various cardiometabolic risk factors. Materials and methods: Cross-sectional study using a sub-sample from the population of a survey conducted in the summer and fall 2007 and 2008 by Canadian Coastguard Ship Amundsen in 36 Canadian Arctic Inuit communities. Subjects included a subset (n = 233) of a total study population (n = 2595) with a mean age 42.56 +/- 15.39 years and body mass index 27.78 +/- 5.65 kg/m(2). Plasma levels of F-2-IsoPs and IsoFs was determined by gas chromatography/ negative ion chemical ionization/mass spectrometry (GC/NICI/MS) method; and their relationships to waist circumference (WC), blood pressure C reactive proteins (CRP), blood lipids and fasting glucose were assessed by multivariate analyses. Results: Plasma F-2-IsoPs correlated positively with CRP (r = .132, P = .048) and systolic blood pressure (SBP) (r = .157, P = .024) after adjustment for age, sex and body mass index. IsoFs correlated with WC (r = .190, P = .005) and SBP (r = .137, P = .048). F-2-IsoPs were not found elevated in smokers (P = .034), whereas IsoFs were decreased in smokers (P = .001). WC, SBP and sex were found to be major correlates of oxidative stress in Canadian Inuit. Conclusions: Plasma measures of F-2-IsoPs and IsoFs increase with increased obesity and associated cardiometabolic risk factors, including CRP and blood pressure. Simultaneous measurement of IsoFs provides an advantageous mechanistic insight into oxidative stress not captured by F-2-IsoPs alone.
C1 [Alkazemi, Dalal; Kubow, Stan] McGill Univ, Sch Dietet & Human Nutr, Ste Anne De Bellevue, PQ H9X 3V9, Canada.
   [Alkazemi, Dalal; Kubow, Stan] McGill Univ, Ctr Indigenous Peoples Nutr & Environm, Ste Anne De Bellevue, PQ H9X 3V9, Canada.
   [Egeland, Grace M.] Univ Bergen, Norwegian Inst Publ Hlth, Bergen, Norway.
   [Egeland, Grace M.] Univ Bergen, Fac Med & Dent, Bergen, Norway.
   [Roberts, Lyman Jackson, II] Vanderbilt Univ, Dept Pharmacol, Nashville, TN USA.
   [Roberts, Lyman Jackson, II] Vanderbilt Univ, Dept Med, Nashville, TN USA.
C3 McGill University; McGill University; University of Bergen; Norwegian
   Institute of Public Health (NIPH); University of Bergen; Vanderbilt
   University; Vanderbilt University
RP Kubow, S (corresponding author), McGill Univ, Sch Dietet & Human Nutr, 21,111 Lakeshore Rd, Ste Anne De Bellevue, PQ H9X 3V9, Canada.
EM stan.kubow@mcgill.ca
RI Kubow, Stan/AAJ-6913-2021; Alkazemi, Dalal Usamah Zaid/E-5481-2018
OI Alkazemi, Dalal Usamah Zaid/0000-0001-9349-2144; Kubow,
   Stan/0000-0001-5831-9880
FU Government of Canada Federal Program for International Polar Year;
   Canadian Institutes of Health Research, Health Canada; Aboriginal
   Affairs and Northern Development Canada; Government of Nunavut;
   University of Toronto; Arctic Net
FX Funding for this work has been provided by Government of Canada Federal
   Program for International Polar Year, Canadian Institutes of Health
   Research, Health Canada, Aboriginal Affairs and Northern Development
   Canada, Government of Nunavut, University of Toronto, and Arctic Net.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Arsenault BJ, 2010, CAN MED ASSOC J, V182, P1427, DOI 10.1503/cmaj.091276
   Basu S, 2006, FREE RADICAL RES, V40, P273, DOI 10.1080/10715760500511492
   Bélanger MC, 2006, METABOLISM, V55, P989, DOI 10.1016/j.metabol.2006.03.007
   Bjerregaard P, 2004, SCAND J PUBLIC HEALT, V32, P390, DOI 10.1080/14034940410028398
   Bjerregaard P, 2003, SCAND J PUBLIC HEALT, V31, P92, DOI 10.1080/14034940210133924
   Brault S, 2003, STROKE, V34, P776, DOI 10.1161/01.STR.0000055763.76479.E6
   Brooks GC, 2010, AM J CARDIOL, V106, P56, DOI 10.1016/j.amjcard.2010.02.017
   Cheung BMY, 2012, J HUM HYPERTENS, V26, P108, DOI 10.1038/jhh.2010.125
   Dietrich M, 2002, AM J EPIDEM IN PRESS, V156, P274
   Egeland GM, 2011, CAN MED ASSOC J, V183, P1022, DOI 10.1503/cmaj.101801
   Forouhi NG, 2001, INT J OBESITY, V25, P1327, DOI 10.1038/sj.ijo.0801723
   Ghanem FA, 2007, J AM SOC HYPERTENS, V1, P113, DOI 10.1016/j.jash.2007.01.004
   Gross M, 2005, CLIN CHEM, V51, P125, DOI 10.1373/clinchem.2004.037630
   Grundy SM, 2004, CIRCULATION, V109, P551, DOI 10.1161/01.CIR.0000112379.88385.67
   Handelman GJ, 2001, KIDNEY INT, V59, P1960, DOI 10.1046/j.1523-1755.2001.0590051960.x
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Helmersson J, 2005, ATHEROSCLEROSIS, V181, P201, DOI 10.1016/j.atherosclerosis.2004.11.026
   Hou X, 2004, FREE RADICAL BIO MED, V36, P163, DOI 10.1016/j.freeradbiomed.2003.10.024
   Il'yasova D, 2005, OBES RES, V13, P1638, DOI 10.1038/oby.2005.201
   JENSEN JA, 1991, ARCH SURG-CHICAGO, V126, P1131
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Lavi S, 2008, HYPERTENSION, V51, P127, DOI 10.1161/HYPERTENSIONAHA.107.099986
   Lemieux I, 2007, CAN J CARDIOL, V23, p23B, DOI 10.1016/S0828-282X(07)71007-3
   Milne GL, 2007, METHOD ENZYMOL, V433, P113, DOI 10.1016/S0076-6879(07)33006-1
   Minuz P, 2002, CIRCULATION, V106, P2800, DOI 10.1161/01.CIR.0000039528.49161.E9
   MORROW JD, 1995, NEW ENGL J MED, V332, P1198, DOI 10.1056/NEJM199505043321804
   Morrow JD, 1999, METHOD ENZYMOL, V300, P3
   Morrow JD, 2005, ARTERIOSCL THROM VAS, V25, P279, DOI 10.1161/01.ATV.0000152605.64964.c0
   Morrow JD, 2003, ARTERIOSCL THROM VAS, V23, P368, DOI 10.1161/01.ATV.0000063107.86298.FD
   Mosca Lori, 2004, J Am Coll Cardiol, V43, P900, DOI 10.1016/j.jacc.2004.02.001
   Pou KM, 2007, CIRCULATION, V116, P1234, DOI 10.1161/CIRCULATIONAHA.107.710509
   Roberts LJ, 2004, CHEM PHYS LIPIDS, V128, P173, DOI 10.1016/j.chemphyslip.2003.09.016
   Singh Uma, 2006, Pathophysiology, V13, P129, DOI 10.1016/j.pathophys.2006.05.002
   Sorensen LT, 2009, J SURG RES, V152, P224, DOI 10.1016/j.jss.2008.02.066
   Stephens JW, 2009, ATHEROSCLEROSIS, V202, P321, DOI 10.1016/j.atherosclerosis.2008.06.006
   Stocker R, 2004, PHYSIOL REV, V84, P1381, DOI 10.1152/physrev.00047.2003
   Szmitko PE, 2003, CIRCULATION, V108, P1917, DOI 10.1161/01.CIR.0000089190.95415.9F
   Ward NC, 2004, FREE RADICAL BIO MED, V36, P226, DOI 10.1016/j.freeradbiomed.2003.10.021
   Young TK, 2007, AM J PUBLIC HEALTH, V97, P691, DOI 10.2105/AJPH.2005.080614
   Zhou YE, 2011, INT J CIRCUMPOL HEAL, V70, P498, DOI 10.3402/ijch.v70i5.17864
NR 41
TC 13
Z9 13
U1 0
U2 5
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1071-5762
J9 FREE RADICAL RES
JI Free Radic. Res.
PD OCT
PY 2012
VL 46
IS 10
BP 1258
EP 1266
DI 10.3109/10715762.2012.702900
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 008HG
UT WOS:000308947400009
PM 22712480
DA 2025-06-11
ER

PT J
AU Kuo, WC
   Bratzke, LC
   Hagen, EW
   Hale, L
   Brown, RL
   Barnet, JH
   Peppard, PE
AF Kuo, Wan-Chin
   Bratzke, Lisa. C.
   Hagen, Erika W. W.
   Hale, Lauren
   Brown, Roger L. L.
   Barnet, Jodi H. H.
   Peppard, Paul E. E.
TI Metabolic health disparities driven by financial stress: Behavioural
   adaptation or modification?
SO STRESS AND HEALTH
LA English
DT Article
DE financial stress; metabolic syndrome; physical activity; sleep duration
ID PHYSICAL-ACTIVITY; SLEEP DURATION; ASSOCIATIONS; RISK; MODERATOR;
   MEDIATOR; STRAIN; PREVALENCE; DEPRESSION; GLUCOSE
AB Financial stress has been linked to an increased risk of metabolic syndrome, yet, it remains unclear whether suboptimal sleep duration and physical inactivity are the adaptive responses to financial stress or effect modifiers in the association between financial stress and metabolic syndrome. Hence, this study aims to examine whether physical activity and sleep duration mediate or moderate the bivariate association between financial stress and metabolic syndrome. A prospective secondary analysis was conducted using data from the Wisconsin Sleep Cohort Study (N = 445, mean [SD] age = 64 [7] years). Baseline moderation effect was examined using subgroup analysis with model constraints; prospective mediation model was examined using bias-corrected bootstrap confidence intervals. Results indicate that participants with higher financial stress were less likely to meet physical activity and sleep recommendations. Baseline moderation analysis indicates that meeting current recommendations of sleep duration and physical activity attenuated the association between financial stress and metabolic syndrome. In the prospective mediation analysis, weekly physical activity levels partially mediated the relationship between financial stress and metabolic syndrome, but sleep duration did not mediate this relationship. In conclusion, the joint effect of optimal sleep duration and physical activity disassociates financial stress from the risk of metabolic syndrome. Future interventions addressing metabolic risk might achieve better outcomes if clinicians and researchers factor in the behavioral adaptation of physical inactivity in financially stressed adults (Clinical Trial Registration: NCT00005557).
C1 [Kuo, Wan-Chin; Bratzke, Lisa. C.; Brown, Roger L. L.] Univ Wisconsin Madison, Sch Nursing, Madison, WI USA.
   [Hagen, Erika W. W.; Barnet, Jodi H. H.; Peppard, Paul E. E.] Univ Wisconsin Madison, Sch Med & Publ Hlth, Dept Populat Hlth Sci, Madison, WI USA.
   [Hale, Lauren] SUNY Stony Brook, Renaissance Sch Med, Dept Family Populat & Prevent Med, Stony Brook, NY USA.
   [Kuo, Wan-Chin] Univ Wisconsin Madison, Sch Nursing, R4121, Signe Skott Cooper Hall, 701 Highland Ave, Madison, WI 53705 USA.
C3 University of Wisconsin System; University of Wisconsin Madison;
   University of Wisconsin System; University of Wisconsin Madison; State
   University of New York (SUNY) System; Stony Brook University; Stony
   Brook University Hospital; University of Wisconsin System; University of
   Wisconsin Madison
RP Kuo, WC (corresponding author), Univ Wisconsin Madison, Sch Nursing, R4121, Signe Skott Cooper Hall, 701 Highland Ave, Madison, WI 53705 USA.
EM wkuo4@wisc.edu
RI Hale, Lauren/K-3227-2013; Kuo, Wan-chin/HHN-6428-2022
OI Kuo, Wan-chin/0000-0002-5658-6077
FU National Institutes of Health
FX NationalInstitutesof Health
CR Agrigoroaei S, 2017, RES AGING, V39, P1075, DOI 10.1177/0164027516658502
   Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Arnett DK, 2019, CIRCULATION, V140, pE563, DOI [10.1016/j.jacc.2019.03.009, 10.1016/j.jacc.2019.03.010, 10.1161/CIR.0000000000000678, 10.1161/CIR.0000000000000677]
   Asparouhov T., 2010, MULTIPLE IMPUTATION
   BARON RM, 1986, J PERS SOC PSYCHOL, V51, P1173, DOI 10.1037/0022-3514.51.6.1173
   Beenackers MA, 2018, EUR J PUBLIC HEALTH, V28, P597, DOI 10.1093/eurpub/ckx212
   Behavioral Risk Factor Surveillance System, 2019, NUTR PHYS ACT OB DAT
   Beyler N., 2010, Statistical methods for analyzing physical activity
   Bruneau M, 2018, MOL GENET GENOM MED, V6, P401, DOI 10.1002/mgg3.368
   Caceres BA, 2022, ETHNIC HEALTH, V27, P617, DOI 10.1080/13557858.2020.1740174
   Commodore-Mensah Y, 2021, AM J HYPERTENS, V34, P707, DOI 10.1093/ajh/hpab011
   Crowe J, 2018, URBAN SCI, V2, DOI 10.3390/urbansci2020046
   D'Lima GM, 2012, PSYCHOL ADDICT BEHAV, V26, P330, DOI 10.1037/a0026942
   de Bruijn EJ, 2022, THEOR DECIS, V92, P5, DOI 10.1007/s11238-021-09802-7
   Du C, 2022, NUTRIENTS, V14, DOI 10.3390/nu14051045
   Easterlin RA, 2000, J ECON PERSPECT, V14, P7, DOI 10.1257/jep.14.1.7
   Ensel WM, 2004, J COMMUNITY PSYCHOL, V32, P81, DOI 10.1002/jcop.10079
   Epel ES, 2018, FRONT NEUROENDOCRIN, V49, P146, DOI 10.1016/j.yfrne.2018.03.001
   Epel ES, 2009, HORM-INT J ENDOCRINO, V8, P7, DOI 10.14310/horm.2002.1217
   Forberger S, 2019, INT J BEHAV NUTR PHY, V16, DOI 10.1186/s12966-019-0844-z
   Foti KE, 2011, AM J PREV MED, V41, P596, DOI 10.1016/j.amepre.2011.08.009
   Fujishiro K, 2011, OCCUP ENVIRON MED, V68, P319, DOI 10.1136/oem.2010.055582
   Fukuoka Y, 2007, APPL NURS RES, V20, P205, DOI 10.1016/j.apnr.2007.01.010
   Hagen EW, 2016, SLEEP, V39, P665, DOI 10.5665/sleep.5548
   Hamer M, 2012, PSYCHOSOM MED, V74, P896, DOI 10.1097/PSY.0b013e31827457f4
   Hirshkowitz M, 2015, SLEEP HEALTH, V1, P40, DOI 10.1016/j.sleh.2014.12.010
   Hostinar CE, 2017, PSYCHOSOM MED, V79, P514, DOI 10.1097/PSY.0000000000000455
   Johnson W, 2006, J PERS SOC PSYCHOL, V90, P680, DOI 10.1037/0022-3514.90.4.680
   Kaminsky LA, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.114.001430
   Karazsia BT, 2018, BEHAV THER, V49, P12, DOI 10.1016/j.beth.2017.10.001
   Kuo WC, 2021, NURS RES, V70, P123, DOI 10.1097/NNR.0000000000000489
   Kuo WC, 2020, CURR ATHEROSCLER REP, V22, DOI 10.1007/s11883-020-00843-x
   Landsbergis PA, 2015, J OCCUP ENVIRON MED, V57, P1178, DOI 10.1097/JOM.0000000000000533
   Lewinsohn PM, 1997, PSYCHOL AGING, V12, P277, DOI 10.1037/0882-7974.12.2.277
   Li CH, 2016, BEHAV RES METHODS, V48, P936, DOI 10.3758/s13428-015-0619-7
   Loeys T, 2015, FRONT PSYCHOL, V5, DOI 10.3389/fpsyg.2014.01549
   Loucks EB, 2016, AM J HEALTH BEHAV, V40, P258, DOI 10.5993/AJHB.40.2.11
   Mackinnon David P, 2004, Multivariate Behav Res, V39, P99
   MacKinnon DP, 2011, RES SOCIAL WORK PRAC, V21, P675, DOI 10.1177/1049731511414148
   Maher JP, 2021, BRIT J HEALTH PSYCH, V26, P861, DOI 10.1111/bjhp.12509
   MCKELVEY RD, 1975, J MATH SOCIOL, V4, P103, DOI 10.1080/0022250X.1975.9989847
   Meier JK, 2022, ELIFE, V11, DOI 10.7554/eLife.67517
   Mesas AE, 2018, SLEEP, V41, DOI 10.1093/sleep/zsy114
   Montano Diego, 2017, Rev Diabet Stud, V14, P279, DOI 10.1900/RDS.2017.14.279
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   Muthen L.K., 2018, Mplus user's guide, V8th ed.
   PAFFENBARGER RS, 1995, AM J EPIDEMIOL, V142, P889, DOI 10.1093/oxfordjournals.aje.a117736
   Peppard PE, 2000, NEW ENGL J MED, V342, P1378, DOI 10.1056/NEJM200005113421901
   Plante DT, 2017, J AFFECT DISORDERS, V207, P197, DOI 10.1016/j.jad.2016.08.039
   Puterman E, 2016, HEALTH PSYCHOL, V35, P191, DOI 10.1037/hea0000258
   Puterman E, 2012, PSYCHOSOM MED, V74, P187, DOI 10.1097/PSY.0b013e3182448d74
   Puterman E, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010837
   Rao ND, 2018, SOC INDIC RES, V138, P225, DOI 10.1007/s11205-017-1650-0
   Rosenberger ME, 2019, MED SCI SPORT EXER, V51, P454, DOI 10.1249/MSS.0000000000001811
   Sabia S, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-22354-2
   SAS Institute Inc, 2020, SAS IML9 4 PROGR BOO
   Schilling R, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0236526
   Schwabe L, 2009, J NEUROSCI, V29, P7191, DOI 10.1523/JNEUROSCI.0979-09.2009
   Shah AK, 2015, PSYCHOL SCI, V26, P402, DOI 10.1177/0956797614563958
   St-Onge MP, 2016, CIRCULATION, V134, pE367, DOI 10.1161/CIR.0000000000000444
   Steen A, 2013, AUSTRALAS ACCOUNT BU, V7, DOI 10.14453/aabfj.v7i3.3
   Stride C.B., 2015, MPLUS CODE MEDIATION
   Suminski RR, 2005, AM J PREV MED, V28, P149, DOI 10.1016/j.amepre.2004.09.009
   Umberson D., 2008, ADV LIFE COURSE RES, V13, P19, DOI [DOI 10.1016/S1040-2608(08)00002-6, 10.1016/S1040-2608(08)00002-6]
   Wang R, 2013, PREV SCI, V14, P111, DOI 10.1007/s11121-011-0221-x
   Winer JR, 2021, JAMA NEUROL, V78, P1187, DOI 10.1001/jamaneurol.2021.2876
   Wood W, 2022, PERSPECT PSYCHOL SCI, V17, P590, DOI 10.1177/1745691621994226
   Young T, 2008, SLEEP, V31, P1071
   Zenko Z, 2019, FRONT PUBLIC HEALTH, V7, DOI 10.3389/fpubh.2019.00135
   Zhao XS, 2010, J CONSUM RES, V37, P197, DOI 10.1086/651257
NR 70
TC 4
Z9 4
U1 1
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1532-3005
EI 1532-2998
J9 STRESS HEALTH
JI Stress Health
PD AUG
PY 2023
VL 39
IS 3
BP 614
EP 626
DI 10.1002/smi.3210
EA DEC 2022
PG 13
WC Psychology, Applied; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA O1SD9
UT WOS:000916166500001
PM 36413205
OA hybrid
DA 2025-06-11
ER

PT J
AU Kendall-Tackett, K
AF Kendall-Tackett, Kathleen
TI Long-Chain Omega-3 Fatty Acids and Women's Mental Health in the
   Perinatal Period and Beyond
SO JOURNAL OF MIDWIFERY & WOMENS HEALTH
LA English
DT Article
DE docosahexaenoic acid; eicosapentaenoic acid; inflammation; omega-3s;
   postpartum depression
ID ETHYL-EICOSAPENTAENOIC ACID; ESSENTIAL FATTY-ACIDS; DOUBLE-BLIND;
   POSTPARTUM DEPRESSION; DOCOSAHEXAENOIC ACID; SEAFOOD CONSUMPTION;
   FISH-OIL; SUPPLEMENTATION; PREGNANCY; SYMPTOMS
AB Recent research has shown that depression and a range of physical illnesses, including heart disease, metabolic syndrome, and type 2 diabetes, have an inflammatory etiology. The long-chain omega-3 fatty acids (omega-3s) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are found in fish and fish-oil products, may protect against these illnesses, in part because they lower inflammation. This article reviews the recent research on omega-3s and women's mental health, with a particular focus on the perinatal period. These studies include population studies examining fish consumption and studies testing the efficacy of EPA and DHA as treatments for depression. Although the findings are mixed, the majority of studies indicate that EPA has efficacy in treating depression either alone or in combination with DHA and/or antidepressant medications. The role of DHA alone in mental health is less clear, but it is generally combined with EPA and appears to have a beneficial effect. In moderate doses, EPA and DHA appear safe for pregnant and postpartum women, and they are well tolerated by patients. J Midwifery Womens Health 2010; 55: 561-567 (C) 2010 by the American College of Nurse-Midwives.
C1 Texas Tech Univ, Dept Pediat, Sch Med, Amarillo, TX 79124 USA.
C3 Texas Tech University System; Texas Tech University
RP Kendall-Tackett, K (corresponding author), Texas Tech Univ, Dept Pediat, Sch Med, 2504 Sweetgum Ln, Amarillo, TX 79124 USA.
EM Kkendallt@aol.com
OI Kendall-Tackett, Kathleen/0000-0003-0709-1059
CR Dunstan JA, 2004, CLIN EXP ALLERGY, V34, P1237, DOI 10.1111/j.1365-2222.2004.02028.x
   Dunstan JA, 2004, EUR J CLIN NUTR, V58, P429, DOI 10.1038/sj.ejcn.1601825
   Ferrucci L, 2006, J CLIN ENDOCR METAB, V91, P439, DOI 10.1210/jc.2005-1303
   Fetterman JW, 2009, AM J HEALTH-SYST PH, V66, P1169, DOI 10.2146/ajhp080411
   Frangou S, 2006, BRIT J PSYCHIAT, V188, P46, DOI 10.1192/bjp.188.1.46
   Freeman MP, 2008, J AFFECT DISORDERS, V110, P142, DOI 10.1016/j.jad.2007.12.228
   Freeman MP, 2007, PROSTAG LEUKOTR ESS, V77, P203, DOI 10.1016/j.plefa.2007.09.004
   Freeman MP, 2006, J CLIN PSYCHIAT, V67, P1954, DOI 10.4088/JCP.v67n1217
   Freeman MP, 2006, ACTA PSYCHIAT SCAND, V113, P31, DOI 10.1111/j.1600-0447.2005.00660.x
   Grandjean P, 2001, INT J EPIDEMIOL, V30, P1272, DOI 10.1093/ije/30.6.1272
   Hallahan B, 2005, BRIT J PSYCHIAT, V186, P275, DOI 10.1192/bjp.186.4.275
   Hallahan B, 2007, BRIT J PSYCHIAT, V190, P118, DOI 10.1192/bjp.bp.106.022707
   Hamazaki K, 2005, NUTRITION, V21, P705, DOI 10.1016/j.nut.2004.07.020
   Hibbeln JR, 2002, J AFFECT DISORDERS, V69, P15, DOI 10.1016/S0165-0327(01)00374-3
   Jordan RG, 2010, J MIDWIFERY WOM HEAL, V55, P520, DOI 10.1016/j.jmwh.2010.02.018
   Kendall-Tackett K., 2010, PSYCHONEUROIMMUNOLOG
   Kendall-Tackett K.A., 2010, Depression in new mothers: Causes, consequences, and treatment alternatives, V2nd
   Kendall-Tackett K, 2007, INT BREASTFEED J, V2, DOI 10.1186/1746-4358-2-6
   Kiecolt-Glaser JK, 2007, PSYCHOSOM MED, V69, P217, DOI 10.1097/PSY.0b013e3180313a45
   Lin PY, 2007, J CLIN PSYCHIAT, V68, P1056, DOI 10.4088/JCP.v68n0712
   Llorente AM, 2003, AM J OBSTET GYNECOL, V188, P1348, DOI 10.1067/mob.2003.275
   Lucas M, 2009, AM J CLIN NUTR, V89, P641, DOI 10.3945/ajcn.2008.26749
   Maes M, 2000, PSYCHONEUROENDOCRINO, V25, P121, DOI 10.1016/S0306-4530(99)00043-8
   Maes M, 1998, BIOL PSYCHIAT, V43, P313
   Maes M, 2000, BIOL PSYCHIAT, V47, P910, DOI 10.1016/S0006-3223(99)00268-1
   Marangell LB, 2004, DEPRESS ANXIETY, V19, P20, DOI 10.1002/da.10148
   McNamara RK, 2009, PROSTAG LEUKOTR ESS, V81, P223, DOI 10.1016/j.plefa.2009.05.017
   Mischoulon D, 2009, OBSTET GYN CLIN N AM, V36, P789, DOI 10.1016/j.ogc.2009.10.005
   Miyake Y, 2006, PSYCHOL MED, V36, P1727, DOI 10.1017/S0033291706008701
   Noaghiul S, 2003, AM J PSYCHIAT, V160, P2222, DOI 10.1176/appi.ajp.160.12.2222
   Olafsdottir AS, 2006, BJOG-INT J OBSTET GY, V113, P301, DOI 10.1111/j.1471-0528.2006.00826.x
   Parker G, 2006, AM J PSYCHIAT, V163, P969, DOI 10.1176/appi.ajp.163.6.969
   Peet M, 2005, DRUGS, V65, P1051, DOI 10.2165/00003495-200565080-00002
   Rees AM, 2005, AUST NZ J PSYCHIAT, V39, P274, DOI 10.1111/j.1440-1614.2005.01565.x
   Robles TF, 2005, CURR DIR PSYCHOL SCI, V14, P111, DOI 10.1111/j.0963-7214.2005.00345.x
   Rogers PJ, 2008, BRIT J NUTR, V99, P421, DOI 10.1017/S0007114507801097
   Romieu I, 2007, CLIN EXP ALLERGY, V37, P518, DOI 10.1111/j.1365-2222.2007.02685.x
   Shoji H, 2006, FREE RADICAL RES, V40, P379, DOI 10.1080/10715760500539147
   Su KP, 2008, J CLIN PSYCHIAT, V69, P644, DOI 10.4088/JCP.v69n0418
   Su KP, 2009, NEUROSIGNALS, V17, P144, DOI 10.1159/000198167
   Sublette ME, 2006, AM J PSYCHIAT, V163, P1100, DOI 10.1176/appi.ajp.163.6.1100
   Szajewska H, 2006, AM J CLIN NUTR, V83, P1337, DOI 10.1093/ajcn/83.6.1337
   Tanskanen A, 2001, PSYCHIATR SERV, V52, P529, DOI 10.1176/appi.ps.52.4.529
   van de Rest O, 2008, AM J CLIN NUTR, V88, P706, DOI 10.1093/ajcn/88.3.706
   van der Watt G, 2008, CURR OPIN PSYCHIATR, V21, P37, DOI 10.1097/YCO.0b013e3282f2d814
NR 45
TC 20
Z9 23
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1526-9523
EI 1542-2011
J9 J MIDWIFERY WOM HEAL
JI J. Midwifery Women Health
PD NOV-DEC
PY 2010
VL 55
IS 6
BP 561
EP 567
DI 10.1016/j.jmwh.2010.02.014
PG 7
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 670QB
UT WOS:000283441300011
PM 20974418
DA 2025-06-11
ER

PT J
AU Jawad, MY
   Meshkat, S
   Tabassum, A
   Mckenzie, A
   Di Vincenzo, JD
   Guo, Z
   Musavi, NB
   Phan, L
   Ceban, F
   Kwan, ATH
   Ramachandra, R
   Le, GH
   Mansur, RB
   Rosenblat, JD
   Ho, R
   Rhee, TG
   McIntyre, RS
AF Jawad, Muhammad Youshay
   Meshkat, Shakila
   Tabassum, Aniqa
   Mckenzie, Andrea
   Di Vincenzo, Joshua D.
   Guo, Ziji
   Musavi, Nabiha Batool
   Phan, Lee
   Ceban, Felicia
   Kwan, Angela T. H.
   Ramachandra, Ranuk
   Le, Gia Han
   Mansur, Rodrigo B.
   Rosenblat, Joshua D.
   Ho, Roger
   Rhee, Taeho Greg
   McIntyre, Roger S.
TI The bidirectional association of nonalcoholic fatty liver disease with
   depression, bipolar disorder, and schizophrenia
SO CNS SPECTRUMS
LA English
DT Review
DE Depression; Bipolar disorder; Mood Disorders; Schizophrenia; NAFLD;
   NASH; Fatty Liver; Metabolic Syndrome; Inflammation; insulin resistance
ID INSULIN-RESISTANCE; CORTISOL SECRETION; IMMUNE-SYSTEM; RISK-FACTORS;
   WEIGHT-GAIN; EARLY-LIFE; INFLAMMATION; PREVALENCE; POPULATION; ANXIETY
AB Nonalcoholic fatty liver disease (NAFLD) is a complex metabolic-inflammatory disease associated with poor outcomes and decreased quality of life. NAFLD is overrepresented in patients with psychiatric disorders like depression, bipolar disorder, and schizophrenia; however, a comprehensive review on NAFLD and psychiatric disorders remains to be delineated. This review endeavors to investigate the association of NAFLD with psychiatric disorders, including shared pathogenesis and future clinical derivatives. Extant literature suggests that patients with psychiatric disorders (in particular, mood disorders) are more susceptible to the development of NAFLD due to multiple reasons, including but not limited to hypothalamic-pituitary-adrenal axis dysregulation, metabolic syndrome, and chronic perceived stress. Moreover, the clinical manifestations of mood disorders (e.g., anhedonia, psychomotor retardation, lifestyle modification, etc.), and potentially long-term treatment with weight-gaining agents, differentially affect these patients, making them more prone to NAFLD. Considering the increased morbidity associated with both mood disorders and NAFLD, our review recommends regular screenings for NAFLD in select patients with mood disorders exhibiting signs of increased risk (i.e., obesity, metabolic syndrome, diabetes, or family history of NAFLD) for better diagnosis and holistic care of both potentially interrelated conditions.
C1 [Jawad, Muhammad Youshay; Meshkat, Shakila; Tabassum, Aniqa; Mckenzie, Andrea; Di Vincenzo, Joshua D.; Phan, Lee; Ceban, Felicia; Kwan, Angela T. H.; Ramachandra, Ranuk; Le, Gia Han; Mansur, Rodrigo B.; Rosenblat, Joshua D.; McIntyre, Roger S.] Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.
   [Jawad, Muhammad Youshay; Guo, Ziji; Ceban, Felicia; Kwan, Angela T. H.; Ramachandra, Ranuk; Le, Gia Han; McIntyre, Roger S.] Brain & Cognit Discovery Fdn, Toronto, ON, Canada.
   [Musavi, Nabiha Batool] Liaquat Natl Med Coll, Karachi, Pakistan.
   [Kwan, Angela T. H.] Univ Ottawa, Fac Med, Ottawa, ON, Canada.
   [Mansur, Rodrigo B.; Rosenblat, Joshua D.; McIntyre, Roger S.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Ho, Roger] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Singapore, Singapore.
   [Ho, Roger] Natl Univ Singapore, Inst Hlth Innovat & Technol iHealthtech, Singapore, Singapore.
   [Rhee, Taeho Greg] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA.
   [Rhee, Taeho Greg] VA Connecticut Healthcare Syst, VA New England Mental Illness Res Educ & Clin Ctr, West Haven, CT USA.
   [Rhee, Taeho Greg] Univ Connecticut, Sch Med, Dept Publ Hlth Sci, Farmington, CT USA.
   [McIntyre, Roger S.] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada.
C3 University of Toronto; University Health Network Toronto; University of
   Ottawa; University of Toronto; National University of Singapore;
   National University of Singapore; Yale University; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); VA Connecticut
   Healthcare System; University of Connecticut; University of Toronto
RP McIntyre, RS (corresponding author), Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.; McIntyre, RS (corresponding author), Brain & Cognit Discovery Fdn, Toronto, ON, Canada.; McIntyre, RS (corresponding author), Univ Toronto, Dept Psychiat, Toronto, ON, Canada.; McIntyre, RS (corresponding author), Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada.
EM roger.mcintyre@bcdf.org
RI McIntyre, Roger/AAU-1000-2020; Di Vincenzo, Joshua/HHS-7099-2022; Kwan,
   Angela/AAX-7569-2021; Mansur, Rodrigo/N-7131-2019; Lê, Gia
   Hân/JGM-8718-2023; Meshkat, Shakila/HHZ-1030-2022; Rhee, Taeho
   Greg/HIZ-6892-2022; Ho, Roger/ABD-9061-2021
OI Tabassum, Aniqa/0000-0003-2928-6711; Kwan, Angela
   T.H./0000-0003-4013-1112; Ramachandra, Ranuk/0000-0002-2542-9802
FU Canadian Institutes of Health Research (CIHR); Physicians' Services
   Incorporated (PSI) Foundation; Baszucki Brain Research Fund; Department
   of Psychiatry, University of Toronto; American Psychiatric Association;
   American Society of Psychopharmacology; Canadian Cancer Society;
   Canadian Psychiatric Association; Joseph M. West Family Memorial Fund;
   Timeposters Fellowship; University Health Network Centre for Mental
   Health; University of Toronto; National Institute on Aging (NIA) through
   Yale School of Medicine [T32AG0191]; NIA; National Institute of Mental
   Health [R21MH117438, R21AG070666]; Institute for Collaboration on
   Health, Intervention, and Policy (InCHIP) of the University of
   Connecticut; CIHR/GACD/National Natural Science Foundation of China
   (NSFC); Milken Institute
FX R.B.M. has received research grant support from the Canadian Institutes
   of Health Research (CIHR), the Physicians' Services Incorporated (PSI)
   Foundation and the Baszucki Brain Research Fund; and support from an
   Academic Scholars Award from the Department of Psychiatry, University of
   Toronto. J.D.R. is the medical director of the Braxia Health (formally
   known as the Canadian Rapid Treatment Center of Excellence and is a
   fully owned subsidiary of Braxia Scientific Corp) which provides
   ketamine and esketamine treatment for depression; he has received
   research grant support from the American Psychiatric Association, the
   American Society of Psychopharmacology, the Canadian Cancer Society, the
   Canadian Psychiatric Association, the Joseph M. West Family Memorial
   Fund, the Timeposters Fellowship, the University Health Network Centre
   for Mental Health, and the University of Toronto and speaking,
   consultation, or research fees from Allergan, COMPASS, Janssen,
   Lundbeck, and Sunovion. was supported in part by the National Institute
   on Aging (NIA) through Yale School of Medicine (#T32AG019134) in the
   past 3 years. T.G.R. has also been funded by the NIA and National
   Institute of Mental Health (#R21MH117438 and R21AG070666) and Institute
   for Collaboration on Health, Intervention, and Policy (InCHIP) of the
   University of Connecticut. R.M. has received research grant support from
   CIHR/GACD/National Natural Science Foundation of China (NSFC) and the
   Milken Institute; speaker/consultation fees from Lundbeck, Janssen,
   Alkermes, Neumora Therapeutics, Boehringer Ingelheim, Sage, Biogen,
   Mitsubishi Tanabe, Purdue, Pfizer, Otsuka, Takeda, Neurocrine, Sunovion,
   Bausch Health, Axsome, Novo Nordisk, Kris, Sanofi, Eisai,
   Intra-Cellular, NewBridge Pharmaceuticals,Viatris, Abbvie, Atai Life
   Sciences. Dr. Roger McIntyre is a CEO of Braxia Scientific Corp.
CR Ahmed A, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0029531
   Angulo P, 2002, NEW ENGL J MED, V346, P1221, DOI 10.1038/nrdp.2015.80
   Arab JP, 2018, ANNU REV PATHOL-MECH, V13, P321, DOI 10.1146/annurev-pathol-020117-043617
   Balp MM, 2019, JHEP REP, V1, P154, DOI 10.1016/j.jhepr.2019.05.009
   Baumeister David, 2014, Curr Top Behav Neurosci, V18, P13, DOI 10.1007/7854_2014_304
   Bayat M, 2021, JKMU, V28, P548, DOI [10.22062/jkmu.2021.91826, DOI 10.22062/JKMU.2021.91826]
   Brenner K, 2009, PSYCHONEUROENDOCRINO, V34, P859, DOI 10.1016/j.psyneuen.2009.01.002
   Buchanan RW, 2010, SCHIZOPHRENIA BULL, V36, P71, DOI 10.1093/schbul/sbp116
   Casey DE, 2004, J CLIN PSYCHIAT, V65, P4
   Caussy Cyrielle, 2019, Current Hepatology Reports, V18, P433, DOI 10.1007/s11901-019-00497-7
   Celikbilek A, 2018, EUR J GASTROEN HEPAT, V30, P944, DOI 10.1097/MEG.0000000000001131
   Cetinkalp S, 2014, CURR VASC PHARMACOL, V12, P553, DOI 10.2174/1570161112999140206130426
   Cha DS, 2012, EXPERT OPIN PHARMACO, V13, P1587, DOI 10.1517/14656566.2012.656590
   Chait A, 2010, ARTERIOSCL THROM VAS, V30, P692, DOI 10.1161/ATVBAHA.110.203984
   Cho IY, 2021, EPIDEMIOL PSYCH SCI, V30, DOI 10.1017/S204579602000116X
   Choi JM, 2021, FRONT MED-LAUSANNE, V7, DOI 10.3389/fmed.2020.585618
   Cyrus S.H., 2014, Advances in Psychiatric Treatment, V20, P101, DOI 10.1192/apt.bp.113.011619
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   Daskalakis NP, 2013, PSYCHONEUROENDOCRINO, V38, P1858, DOI 10.1016/j.psyneuen.2013.06.008
   Dienes KA, 2013, PSYCHONEUROENDOCRINO, V38, P927, DOI 10.1016/j.psyneuen.2012.09.019
   Elwing JE, 2006, PSYCHOSOM MED, V68, P563, DOI 10.1097/01.psy.0000221276.17823.df
   Ferrante AW, 2007, J INTERN MED, V262, P408, DOI 10.1111/j.1365-2796.2007.01852.x
   Filipovic B, 2018, CAN J GASTROENTEROL, V2018, DOI 10.1155/2018/9638797
   Fuller BE, 2011, GEN HOSP PSYCHIAT, V33, P232, DOI 10.1016/j.genhosppsych.2011.03.006
   Gafoor R, 2018, BMJ-BRIT MED J, V361, DOI 10.1136/bmj.k1951
   Godin O, 2021, ACTA PSYCHIAT SCAND, V143, P82, DOI 10.1111/acps.13239
   Gu YP, 2022, J AFFECT DISORDERS, V301, P8, DOI 10.1016/j.jad.2021.12.128
   Hamer JA, 2019, EXP NEUROL, V315, P1, DOI 10.1016/j.expneurol.2019.01.016
   Hammen C, 2005, ANNU REV CLIN PSYCHO, V1, P293, DOI 10.1146/annurev.clinpsy.1.102803.143938
   Heim Christine, 2002, Semin Clin Neuropsychiatry, V7, P147, DOI 10.1053/scnp.2002.33127
   Hsu JH, 2014, PSYCHOSOMATICS, V55, P163, DOI 10.1016/j.psym.2013.06.001
   Huang R, 2021, HEALTH QUAL LIFE OUT, V19, DOI 10.1186/s12955-021-01778-w
   Jawad MY, 2022, J AFFECT DISORDERS, V301, P99, DOI 10.1016/j.jad.2022.01.004
   Morlán-Coarasa MJ, 2016, PSYCHOPHARMACOLOGY, V233, P3947, DOI 10.1007/s00213-016-4422-7
   Jung JY, 2019, J KOREAN MED SCI, V34, DOI 10.3346/jkms.2019.34.e199
   Kahn RS, 2015, NAT REV DIS PRIMERS, V1, DOI 10.1038/nrdp.2015.67
   Kang D, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-019-57036-z
   Kenneson A, 2017, J AFFECT DISORDERS, V209, P93, DOI 10.1016/j.jad.2016.11.035
   Koreki A, 2021, J CLIN PSYCHOPHARM, V41, P474, DOI 10.1097/JCP.0000000000001421
   Lazarus JV, 2022, NAT REV GASTRO HEPAT, V19, P60, DOI 10.1038/s41575-021-00523-4
   Lecic-Tosevski D, 2011, Psychiatriki, V22, P290
   Lee JW, 2021, J AFFECT DISORDERS, V278, P259, DOI 10.1016/j.jad.2020.09.073
   Lee K, 2013, PSYCHOSOMATICS, V54, P52, DOI 10.1016/j.psym.2012.09.005
   Lee SH, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.25
   Lee Y, 2018, THER ADV PSYCHOPHARM, V8, P337, DOI 10.1177/2045125318791944
   Liu Y, 2012, J AFFECT DISORDERS, V139, P230, DOI 10.1016/j.jad.2011.08.003
   Lloyd C., 2005, Diabetes Spectrum, V18, P121, DOI 10.2337/diaspect.18.2.121
   Lonardo A, 2021, J CLIN MED, V10, DOI 10.3390/jcm10030492
   Lu Y, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0170418
   Luef GJ, 2004, ANN NEUROL, V55, P729, DOI 10.1002/ana.20074
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Ma QY, 2021, HEPATOL INT, V15, P127, DOI 10.1007/s12072-020-10132-z
   Machado MV, 2016, GASTROENTEROLOGY, V150, P1769, DOI 10.1053/j.gastro.2016.02.066
   Mansur RB, 2020, NEUROSCI BIOBEHAV R, V113, P529, DOI 10.1016/j.neubiorev.2020.04.006
   Mansur RB, 2015, NEUROSCI BIOBEHAV R, V52, P89, DOI 10.1016/j.neubiorev.2014.12.017
   Manu P, 2015, ACTA PSYCHIAT SCAND, V132, P97, DOI 10.1111/acps.12445
   McIntyre RS, 2020, LANCET, V396, P1841, DOI 10.1016/S0140-6736(20)31544-0
   McIntyre RS, 2015, CNS SPECTRUMS, V20, P20, DOI 10.1017/S1092852915000826
   McIntyre RS, 2013, DEPRESS ANXIETY, V30, P515, DOI 10.1002/da.22063
   McIntyre RS, 2010, J AFFECT DISORDERS, V126, P366, DOI 10.1016/j.jad.2010.04.012
   McIntyre RS, 2009, CURR DIABETES REP, V9, P51, DOI 10.1007/s11892-009-0010-0
   Mundi MS, 2020, NUTR CLIN PRACT, V35, P72, DOI 10.1002/ncp.10449
   Nabi O, 2020, GASTROENTEROLOGY, V159, P791, DOI 10.1053/j.gastro.2020.04.048
   Nolan CJ, 2019, DIABETES VASC DIS RE, V16, P118, DOI 10.1177/1479164119827611
   Noon SL, 2021, J PEDIATR GASTR NUTR, V72, P579, DOI 10.1097/MPG.0000000000003024
   Otte C, 2016, NAT REV DIS PRIMERS, V2, DOI 10.1038/nrdp.2016.65
   Pan ZH, 2019, CNS SPECTRUMS, V24, P22, DOI 10.1017/S1092852918001207
   Pandyarajan Vijay, 2019, Gastroenterol Hepatol (N Y), V15, P357
   Papadimitriou A, 2009, NEUROIMMUNOMODULAT, V16, P265, DOI 10.1159/000216184
   Pillinger T, 2020, LANCET PSYCHIAT, V7, P64, DOI 10.1016/S2215-0366(19)30416-X
   Rodriguez B, 2012, NAT REV GASTRO HEPAT, V9, P726, DOI 10.1038/nrgastro.2012.200
   Rodríguez-Hernández H, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/678159
   Rosenblat JD, 2014, PROG NEURO-PSYCHOPH, V53, P23, DOI 10.1016/j.pnpbp.2014.01.013
   Roshanaei-Moghaddam B, 2009, GEN HOSP PSYCHIAT, V31, P306, DOI 10.1016/j.genhosppsych.2009.04.002
   Rostama B, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21249362
   SayuriYamagata A, 2017, J AFFECT DISORDERS, V211, P99, DOI 10.1016/j.jad.2016.12.059
   Shaheen AA, 2021, LIVER INT, V41, P2308, DOI 10.1111/liv.14973
   Shea S, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9111697
   Shields GS, 2015, PSYCHONEUROENDOCRINO, V58, P91, DOI 10.1016/j.psyneuen.2015.04.017
   Smith Sean M, 2006, Dialogues Clin Neurosci, V8, P383
   Soczynska JK, 2011, NEUROMOL MED, V13, P93, DOI 10.1007/s12017-010-8140-8
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Soto-Angona O, 2020, BMC MED, V18, DOI 10.1186/s12916-020-01713-8
   Steptoe A, 2012, NAT REV CARDIOL, V9, P360, DOI 10.1038/nrcardio.2012.45
   Steudte S, 2011, PSYCHONEUROENDOCRINO, V36, P1193, DOI 10.1016/j.psyneuen.2011.02.012
   Stubbs B, 2018, LANCET PSYCHIAT, V5, P873, DOI 10.1016/S2215-0366(18)30343-2
   Tahmi M, 2021, CURR CARDIOL REP, V23, DOI 10.1007/s11886-021-01615-y
   Tarantino G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms231810406
   Targher G, 2006, CLIN ENDOCRINOL, V64, P337, DOI 10.1111/j.1365-2265.2006.02466.x
   Targher G, 2020, GUT, V69, P1691, DOI 10.1136/gutjnl-2020-320622
   Thau L., 2021, StatPearls
   Tilg H, 2017, NAT REV GASTRO HEPAT, V14, P32, DOI 10.1038/nrgastro.2016.147
   Tomeno W, 2015, J GASTROEN HEPATOL, V30, P1009, DOI 10.1111/jgh.12897
   Tossani E, 2013, PSYCHOTHER PSYCHOSOM, V82, P67, DOI 10.1159/000343003
   Von-Hafe M, 2022, METABOLITES, V12, DOI 10.3390/metabo12040298
   Wang NJ, 2016, J CLIN ENDOCR METAB, V101, P2218, DOI 10.1210/jc.2016-1076
   Wang W, 2022, NEUROSCIENCE, V480, P178, DOI 10.1016/j.neuroscience.2021.11.015
   Watt MJ, 2019, ENDOCR REV, V40, P1367, DOI 10.1210/er.2019-00034
   WHO, 2017, ABOUT US
   Yan J, 2017, NEUROPSYCH DIS TREAT, V13, P1493, DOI 10.2147/NDT.S137183
   Yang S, 2022, HEPATOL RES, V52, P176, DOI 10.1111/hepr.13728
   Younossi ZM, 2015, HEPATOLOGY, V62, p739A, DOI 10.1002/hep.28431
   Youssef NA, 2013, LIVER INT, V33, P1062, DOI 10.1111/liv.12165
NR 103
TC 21
Z9 22
U1 1
U2 15
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 1092-8529
EI 2165-6509
J9 CNS SPECTRUMS
JI CNS Spectr.
PD OCT
PY 2023
VL 28
IS 5
BP 541
EP 560
AR PII S1092852922001043
DI 10.1017/S1092852922001043
EA OCT 2022
PG 20
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA U5HX1
UT WOS:000889873300001
PM 36268655
DA 2025-06-11
ER

PT J
AU Després, JP
AF Despres, Jean-Pierre
TI Pleiotropic Effects of Rimonabant: Clinical Implications
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Abdominal obesity; cardiometabolic risk; cardiovascular disease;
   endocannabinoid system; intra-abdominal adiposity; obesity; rimonabant;
   type 2 diabetes
ID CORONARY-HEART-DISEASE; CARDIOMETABOLIC RISK-FACTORS;
   HYPERTRIGLYCERIDEMIC WAIST PHENOTYPE; MOLECULAR-WEIGHT ADIPONECTIN; CB1
   RECEPTOR ANTAGONIST; C-REACTIVE PROTEIN; BODY-MASS INDEX; ATHEROGENIC
   METABOLIC TRIAD; ADIPOSE-TISSUE ACCUMULATION; IMPAIRED FASTING GLUCOSE
AB Abdominal obesity (high waist circumference) is more strongly associated with cardiovascular disease and type 2 diabetes than generalized adiposity (high body mass index). Recent research has highlighted the role of chronic overactivation of the endogenous endocannabinoid system, acting through its CB1 receptor, as a key factor involved in the development of abdominal obesity and related cardiometabolic risk abnormalities such as insulin resistance, low HDL-cholesterol, hypertriglyceridemia, inflammation and low adiponectin. Evidence suggests that these cardiometabolic risk factors/markers are not optimally managed by current treatments. Improving the nutrition and physical activity/exercise habits of patients remains the cornerstone of management of elevated global cardiometabolic risk. Antagonism of the endocannabinoid system provides a novel strategy to target several unaddressed cardiometabolic risk markers/factors. Randomized trials of rimonabant in patients with overweight or obesity and/or type 2 diabetes have demonstrated marked and significant improvements in body weight, waist circumference, glycemic control (in patients with type 2 diabetes), features of atherogenic dyslipidemia, insulin resistance, adipose tissue-derived cytokines (leptin and adiponectin) and C-reactive protein (a marker of systemic inflammation). Further analyses suggested that about half of the improvements of several cardiometabolic risk markers were independent from concomitant weight loss. Blood pressure also improved with rimonabant treatment, this effect being consistent with the blood pressure lowering effect of weight loss. The tolerability and safety of rimonabant have been extensively studied and most transient side effects include some gastrointestinal side effects, anxiety, mood changes and incidence of depressive disorders, particularly in patients with previous history of depression. Rimonabant is a useful option for patients with abdominal obesity and with related cardiometabolic risk abnormalities such as an atherogenic dyslipidemia and/or type 2 diabetes.
C1 [Despres, Jean-Pierre] Hop Laval, Res Ctr, Quebec Heart Inst, Quebec City, PQ G1V 4G5, Canada.
   [Despres, Jean-Pierre] Univ Laval, Dept Social & Prevent Med, Div Kinesiol, Quebec City, PQ, Canada.
C3 Laval University; Laval University Hospital; Laval University
RP Després, JP (corresponding author), Hop Laval, Res Ctr, Quebec Heart Inst, 2725 Chemin Ste Foy,Pavil Marguerite DYouville,4t, Quebec City, PQ G1V 4G5, Canada.
EM Jean-Pierre.Despres@crhl.ulaval.ca
FU Canadian Institutes of Health Research; Canadian Diabetes Association;
   Heart and Stroke Foundation; Foundation of the Quebec Heart Institute;
   Sanofi aventis
FX The work of the author has been supported by research grants from the
   Canadian Institutes of Health Research, the Canadian Diabetes
   Association, the Heart and Stroke Foundation and by the Foundation of
   the Quebec Heart Institute. Dr. Despres is the Scientific Director of
   the International Chair on Cardiometabolic Risk, which is supported by
   an unrestricted grant from Sanofi aventis awarded to Universite Laval.
CR Alberti KGMM, 2007, DIABETIC MED, V24, P451, DOI 10.1111/j.1464-5491.2007.02157.x
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Alexander CM, 2003, DIABETES, V52, P1210, DOI 10.2337/diabetes.52.5.1210
   [Anonymous], HLTH STAT HLTH INF S
   Araki T, 2006, METABOLISM, V55, P996, DOI 10.1016/j.metabol.2006.03.008
   Arsenault BJ, 2007, ARCH INTERN MED, V167, P1518, DOI 10.1001/archinte.167.14.1518
   AUSTIN MA, 1995, INT J OBESITY, V19, pS22
   *AUSTR BUR STAT, MORT TRENDS PEOPL AG
   Balkau B, 2003, DIABETES METAB, V29, P526, DOI 10.1016/S1262-3636(07)70067-8
   Balkau B, 2007, CIRCULATION, V116, P1942, DOI 10.1161/CIRCULATIONAHA.106.676379
   Basu R, 2007, DIABETES, V56, P2174, DOI 10.2337/db07-0185
   Bell D, 2004, ASIA PAC J CLIN NUTR, V13, P74
   Bensaid M, 2003, MOL PHARMACOL, V63, P908, DOI 10.1124/mol.63.4.908
   Bibbins-Domingo K, 2007, NEW ENGL J MED, V357, P2371, DOI 10.1056/NEJMsa073166
   Blackburn P, 2003, ATHEROSCLEROSIS, V171, P327, DOI 10.1016/j.atherosclerosis.2003.06.001
   Blackburn P, 2008, DIABETES CARE, V31, P170, DOI 10.2337/dc07-0272
   Blüher M, 2006, DIABETES, V55, P3053, DOI 10.2337/db06-0812
   Borst SE, 2005, CYTOKINE, V32, P39, DOI 10.1016/j.cyto.2005.07.008
   Carey VJ, 1997, AM J EPIDEMIOL, V145, P614, DOI 10.1093/oxfordjournals.aje.a009158
   Cartier A, 2008, J CLIN ENDOCR METAB, V93, P1931, DOI 10.1210/jc.2007-2191
   CHEW P, 2007, CLIN SAFETY
   Chow WS, 2007, HYPERTENSION, V49, P1455, DOI 10.1161/HYPERTENSIONAHA.107.086835
   Christensen R, 2007, LANCET, V370, P1706, DOI 10.1016/S0140-6736(07)61721-8
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cota D, 2003, J CLIN INVEST, V112, P423, DOI 10.1172/JCI17725
   Côté M, 2007, INT J OBESITY, V31, P692, DOI 10.1038/sj.ijo.0803539
   Côté M, 2005, J CLIN ENDOCR METAB, V90, P1434, DOI 10.1210/jc.2004-1711
   Després JP, 2008, ANN MED, V40, P514, DOI 10.1080/07853890802004959
   Després JP, 2008, EUR HEART J SUPPL, V10, pB24, DOI 10.1093/eurheartj/sum041
   Després JP, 2008, ARTERIOSCL THROM VAS, V28, P1039, DOI 10.1161/ATVBAHA.107.159228
   Despres Jean-Pierre, 2007, Crit Pathw Cardiol, V6, P51, DOI 10.1097/HPC.0b013e318057d4c9
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Després JP, 2006, ANN MED, V38, P52, DOI 10.1080/07853890500383895
   Despres JP, 2005, NEW ENGL J MED, V353, P2121, DOI 10.1056/NEJMoa044537
   Després JP, 2001, BMJ-BRIT MED J, V322, P716, DOI 10.1136/bmj.322.7288.716
   Després JP, 2001, BRIT MED J, V322, P1379, DOI 10.1136/bmj.322.7299.1379
   DESPRES JP, 1990, ARTERIOSCLEROSIS, V10, P497, DOI 10.1161/01.ATV.10.4.497
   Di Marzo V, 2001, NATURE, V410, P822, DOI 10.1038/35071088
   Empana JP, 2004, CIRCULATION, V110, P2781, DOI 10.1161/01.CIR.0000146395.64065.BA
   Engeli S, 2005, DIABETES, V54, P2838, DOI 10.2337/diabetes.54.10.2838
   Erem C, 2004, OBES RES, V12, P1117, DOI 10.1038/oby.2004.140
   Farin HMF, 2006, AM J CARDIOL, V98, P1053, DOI 10.1016/j.amjcard.2006.05.025
   Ferrannini E, 2007, J CLIN ENDOCR METAB, V92, P396, DOI 10.1210/jc.2006-0944
   Fezeu L, 2006, INT J EPIDEMIOL, V35, P105, DOI 10.1093/ije/dyi214
   FLIER JS, 1995, CELL, V80, P15, DOI 10.1016/0092-8674(95)90445-X
   *FOOD DRUG ADM, 21888 FDA NDA
   Ford ES, 2007, NEW ENGL J MED, V356, P2388, DOI 10.1056/NEJMsa053935
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   Fox CS, 2008, DIABETES CARE, V31, P1582, DOI 10.2337/dc08-0025
   Fox CS, 2007, CIRCULATION, V116, P39, DOI 10.1161/CIRCULATIONAHA.106.675355
   Francischetti EA, 2007, METABOLISM, V56, P1464, DOI 10.1016/j.metabol.2007.06.011
   Gaede P, 2003, NEW ENGL J MED, V348, P383, DOI 10.1056/NEJMoa021778
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Gale EAM, 2005, DIABETOLOGIA, V48, P1679, DOI 10.1007/s00125-005-1873-5
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Gazi IF, 2008, DIABETES-METAB RES, V24, P223, DOI 10.1002/dmrr.784
   GOLDSMITH SJ, 1992, INT J EAT DISORDER, V12, P63, DOI 10.1002/1098-108X(199207)12:1<63::AID-EAT2260120109>3.0.CO;2-5
   Greenfield JR, 2008, CURR PHARM DESIGN, V14, P1815, DOI 10.2174/138161208784746716
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Haslam D, 2005, BMJ-BRIT MED J, V331, P455, DOI 10.1136/bmj.331.7514.455-b
   Heilbronn LK, 2008, CURR PHARM DESIGN, V14, P1225, DOI 10.2174/138161208784246153
   HEINRICH PC, 1990, BIOCHEM J, V265, P621, DOI 10.1042/bj2650621
   Hoefle G, 2005, INT J OBESITY, V29, P785, DOI 10.1038/sj.ijo.0802985
   *INT DIAB FED, DIAB E ATL
   Janiszewski PM, 2007, DIABETES CARE, V30, P3105, DOI 10.2337/dc07-0945
   Jia W P, 2002, Obes Rev, V3, P157
   Jorgensen ME, 2003, INT J OBESITY, V27, P1507, DOI 10.1038/sj.ijo.0802434
   JuhanVague I, 1997, THROMB HAEMOSTASIS, V78, P656
   Kahn HS, 2003, AM J CLIN NUTR, V78, P928, DOI 10.1093/ajcn/78.5.928
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   Katsuki A, 2006, DIABETES CARE, V29, P2327, DOI 10.2337/dc06-1239
   Kim SK, 2004, AM J CLIN NUTR, V79, P593
   Klein S, 2007, DIABETES CARE, V30, P1647, DOI 10.2337/dc07-9921
   Koenig W, 2004, CIRCULATION, V109, P1349, DOI 10.1161/01.CIR.0000120707.98922.E3
   Koenig W, 2006, J AM COLL CARDIOL, V48, P1369, DOI 10.1016/j.jacc.2006.06.053
   Kuk JL, 2006, OBESITY, V14, P336, DOI 10.1038/oby.2006.43
   Lamarche B, 1998, JAMA-J AM MED ASSOC, V279, P1955, DOI 10.1001/jama.279.24.1955
   Lanas F, 2007, CIRCULATION, V115, P1067, DOI 10.1161/CIRCULATIONAHA.106.633552
   LARSSON B, 1984, BMJ-BRIT MED J, V288, P1401, DOI 10.1136/bmj.288.6428.1401
   LEAN MEJ, 1995, BRIT MED J, V311, P158, DOI 10.1136/bmj.311.6998.158
   Ledoux M, 1997, CAN MED ASSOC J, V157, pS32
   Lee K, 2008, NUTRITION, V24, P625, DOI 10.1016/j.nut.2008.03.004
   Lemieux I, 2002, CAN J CARDIOL, V18, P725
   Lemieux I, 2001, ARTERIOSCL THROM VAS, V21, P961, DOI 10.1161/01.ATV.21.6.961
   Lemieux I, 2000, CIRCULATION, V102, P179, DOI 10.1161/01.CIR.102.2.179
   Lemieux I, 2007, CAN J CARDIOL, V23, p23B, DOI 10.1016/S0828-282X(07)71007-3
   Lemieux S, 1996, AM J CLIN NUTR, V64, P685, DOI 10.1093/ajcn/64.5.685
   Li TY, 2006, CIRCULATION, V113, P499, DOI 10.1161/CIRCULATIONAHA.105.574087
   Libby P, 2002, CIRCULATION, V106, P2760, DOI 10.1161/01.CIR.0000037282.92395.AE
   Lim S, 2008, ATHEROSCLEROSIS, V196, P398, DOI 10.1016/j.atherosclerosis.2006.11.017
   Liu YL, 2005, INT J OBESITY, V29, P183, DOI 10.1038/sj.ijo.0802847
   Lorenzo C, 2003, OBES RES, V11, P1480, DOI 10.1038/oby.2003.198
   Lorenzo C, 2007, DIABETES CARE, V30, P2141, DOI 10.2337/dc06-2627
   Marso SP, 2008, DIABETES CARE, V31, P989, DOI 10.2337/dc07-2024
   Mather KJ, 2008, DIABETES, V57, P980, DOI 10.2337/db07-1419
   Matias I, 2006, J CLIN ENDOCR METAB, V91, P3171, DOI 10.1210/jc.2005-2679
   Mitsuhashi H, 2007, HYPERTENSION, V49, P1448, DOI 10.1161/HYPERTENSIONAHA.106.079509
   Moreau M, 2004, INT J OBESITY, V28, P574, DOI 10.1038/sj.ijo.0802600
   Mueller-Nordhorn J, 2008, EUR HEART J, V29, P1316, DOI 10.1093/eurheartj/ehm604
   Müller-Nordhorn J, 2004, J EPIDEMIOL COMMUN H, V58, P481, DOI 10.1136/jech.2003.013367
   Nathan DM, 2007, DIABETES CARE, V30, P753, DOI 10.2337/dc07-9920
   Nissen SE, 2008, JAMA-J AM MED ASSOC, V299, P1547, DOI 10.1001/jama.299.13.1547
   Osei-Hyiaman D, 2005, J CLIN INVEST, V115, P1298, DOI 10.1172/JCI200523057
   Pagotto U, 2005, ANN MED, V37, P270, DOI 10.1080/07853890510037419
   Pagotto U, 2005, LANCET, V365, P1363, DOI 10.1016/S0140-6736(05)66348-9
   Palmer SL, 2002, CHEM PHYS LIPIDS, V121, P3, DOI 10.1016/S0009-3084(02)00143-3
   Park HS, 2005, DIABETES RES CLIN PR, V69, P29, DOI 10.1016/j.diabres.2004.11.007
   Park HS, 2004, INT J EPIDEMIOL, V33, P328, DOI 10.1093/ije/dyh032
   Park KG, 2004, DIABETES RES CLIN PR, V63, P135, DOI 10.1016/j.diabres.2003.09.010
   Pascot A, 2000, DIABETOLOGIA, V43, P1126, DOI 10.1007/s001250051503
   Pazos MR, 2005, PHARMACOL BIOCHEM BE, V81, P239, DOI 10.1016/j.pbb.2005.01.030
   Pi-Sunyer F, 2006, JAMA-J AM MED ASSOC, V295, P761, DOI 10.1001/jama.295.7.761
   Poirier P, 2005, HYPERTENSION, V45, P363, DOI 10.1161/01.HYP.0000155463.90018.dc
   POULIOT MC, 1994, AM J CARDIOL, V73, P460, DOI 10.1016/0002-9149(94)90676-9
   POULIOT MC, 1992, DIABETES, V41, P826, DOI 10.2337/diabetes.41.7.826
   Preiss D, 2007, HEART, V93, P1493, DOI 10.1136/hrt.2007.130849
   Reeder BA, 1997, CAN MED ASSOC J, V157, pS39
   Rexrode KM, 1998, JAMA-J AM MED ASSOC, V280, P1843, DOI 10.1001/jama.280.21.1843
   Ridker PM, 2002, NEW ENGL J MED, V347, P1557, DOI 10.1056/NEJMoa021993
   Rosenstock J, 2008, DIABETES CARE, V31, P2169, DOI 10.2337/dc08-0386
   Ross R, 2002, J CLIN ENDOCR METAB, V87, P5044, DOI 10.1210/jc.2002-020570
   Ross R, 2002, AM J PHYSIOL-ENDOC M, V282, pE657, DOI 10.1152/ajpendo.00469.2001
   Ruilopea LM, 2008, J HYPERTENS, V26, P357, DOI 10.1097/HJH.0b013e3282f2d625
   Sam S, 2008, DIABETES, V57, P2022, DOI 10.2337/db08-0157
   Sattar N, 2006, CIRCULATION, V114, P623, DOI 10.1161/CIRCULATIONAHA.106.618918
   Scheen AJ, 2006, LANCET, V368, P1660, DOI 10.1016/S0140-6736(06)69571-8
   Schober F, 2007, BIOCHEM BIOPH RES CO, V361, P968, DOI 10.1016/j.bbrc.2007.07.106
   Seidell JC, 2001, AM J CLIN NUTR, V74, P315
   Sekikawa A, 1999, INT J EPIDEMIOL, V28, P1044, DOI 10.1093/ije/28.6.1044
   Shioji K, 2007, CIRC J, V71, P675, DOI 10.1253/circj.71.675
   St-Pierre J, 2002, AM J CARDIOL, V90, P15, DOI 10.1016/S0002-9149(02)02378-0
   St-Pierre J, 2007, AM J CARDIOL, V99, P369, DOI 10.1016/j.amjcard.2006.08.041
   Sung KC, 2007, METABOLISM, V56, P297, DOI 10.1016/j.metabol.2006.09.016
   Tamura T, 2007, CIRC J, V71, P623, DOI 10.1253/circj.71.623
   Tan CE, 2004, DIABETES CARE, V27, P1182, DOI 10.2337/diacare.27.5.1182
   Tanaka S, 2004, INT J OBESITY, V28, P320, DOI 10.1038/sj.ijo.0802545
   Tchernof A, 1996, DIABETES CARE, V19, P629, DOI 10.2337/diacare.19.6.629
   THOM TJ, 1994, CIRCULATION, V90, P574, DOI 10.1161/01.CIR.90.1.574
   Thompson CS, 2008, CURR PHARM DESIGN, V14, P309, DOI 10.2174/138161208783497679
   Turner RC, 1998, LANCET, V352, P837, DOI 10.1016/s0140-6736(98)07019-6
   VAGUE J, 1947, PRESSE MED, V55, P339
   Van Gaal LF, 2005, LANCET, V365, P1389, DOI 10.1016/S0140-6736(05)66374-X
   Van Gaal L, 2008, DIABETES CARE, V31, pS229, DOI 10.2337/dc08-s258
   Van Gaal LF, 2008, EUR HEART J, V29, P1761, DOI 10.1093/eurheartj/ehn076
   von Eynatten M, 2008, ATHEROSCLEROSIS, V199, P123, DOI 10.1016/j.atherosclerosis.2007.10.002
   Wang YF, 2005, AM J CLIN NUTR, V81, P555
   Weltman A, 2003, METABOLISM, V52, P73, DOI 10.1053/meta.2003.50007
   *WHO COLL CTR SURV, GROW BURD HEART DIS
   Wittchen HU, 2006, EUR HEART J SUPPL, V8, pB26, DOI 10.1093/eurheartj/sul005
   Wittchen HU, 2005, CURR MED RES OPIN, V21, P619, DOI 10.1185/030079905X38187
   Yap S, 2006, J HUM HYPERTENS, V20, P904, DOI 10.1038/sj.jhh.1002081
   Yusuf S, 2005, LANCET, V366, P1640, DOI 10.1016/S0140-6736(05)67663-5
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
NR 155
TC 25
Z9 28
U1 0
U2 2
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD FEB
PY 2009
VL 15
IS 5
BP 553
EP 570
DI 10.2174/138161209787315666
PG 18
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 415VG
UT WOS:000263963600008
PM 19199981
DA 2025-06-11
ER

PT J
AU Li, HX
   George, DM
   Jaarsma, RL
   Mao, XZ
AF Li, Hongxing
   George, Daniel M.
   Jaarsma, Ruurd L.
   Mao, Xinzhan
TI Metabolic syndrome and components exacerbate osteoarthritis symptoms of
   pain, depression and reduced knee function
SO ANNALS OF TRANSLATIONAL MEDICINE
LA English
DT Article
DE Hyperglycemia; hypertension; metabolic syndrome X; obesity;
   osteoarthritis
ID DEPENDENT DIABETES-MELLITUS; PREVALENCE; OBESITY; HAND; EPIDEMIOLOGY;
   PATHOGENESIS; ASSOCIATION; POPULATION; PREDICTOR; CARTILAGE
AB Background: The purpose of this study was to investigate the prevalence of metabolic syndrome and its co-morbidities in patients with primary knee osteoarthritis and to assess if the severity of metabolic syndrome, and components, correlates with the severity of osteoarthritis symptoms.
   Methods: A case controlled analysis of 70 patients with osteoarthritis compared to a control group of 81 patients. Each patient underwent clinical review including history, examination, and pathology tests. The case-group all had stage IV osteoarthritis as determined by radiographs and intra-operative assessment. In addition a visual analogue scale (VAS), Hospital for Special Surgery knee score (HSS), and Hamilton Depression scores were completed.
   Results: The prevalence of hypertension, obesity, dyslipidemia and metabolic syndrome was significantly higher in the patients with osteoarthritis compared to the control group. There is a significant correlation between the degree of hypertension, the presence of dyslipidemia or hyperglycemia and the severity of osteoarthritis symptoms. Variables hypertension, low HDL-C levels, and the number of co-morbidities were all identified as risk factors for increased osteoarthritis symptoms.
   Conclusions: There is a correlation between the number of metabolic disorders, the severity of hypertension and severity of osteoarthritis symptoms. Hypertension and decreased HDL-cholesterol were positive risk factors for increased osteoarthritis symptomatology.
C1 [Li, Hongxing] Cent Hosp Shaoyang, Dept Orthopaed Surg, Shaoyang 422000, Peoples R China.
   [George, Daniel M.; Jaarsma, Ruurd L.] Flinders Univ S Australia, Sch Med, Dept Orthopaed, Adelaide, SA, Australia.
   [George, Daniel M.; Jaarsma, Ruurd L.] Flinders Med Ctr, Dept Orthopaed & Trauma, Adelaide, SA, Australia.
   [Mao, Xinzhan] 2nd Xiangya Hosp, Dept Orthopaed Surg, Level 16,139 Peoples Rd, Changsha 410011, Hunan, Peoples R China.
C3 Flinders University South Australia; Flinders Medical Centre
RP Mao, XZ (corresponding author), 2nd Xiangya Hosp, Dept Orthopaed Surg, Level 16,139 Peoples Rd, Changsha 410011, Hunan, Peoples R China.
EM MaoXinzhan72@126.com
OI Jaarsma, Ruurd/0000-0003-4308-7815; George, Daniel/0000-0002-1853-2983
FU National Natural Science Foundation of China [81371997]
FX Professor Mao now receives funding from the National Natural Science
   Foundation of China (81371997) for future research into osteoarthritis
   and its treatment.
CR ANDERSON JJ, 1988, AM J EPIDEMIOL, V128, P179, DOI 10.1093/oxfordjournals.aje.a114939
   APPENZELLER O, 1991, MED CLIN N AM, V75, P763, DOI 10.1016/S0025-7125(16)30448-5
   Bastiaansen-Jenniskens YM, 2012, ANN RHEUM DIS, V71, P288, DOI 10.1136/ard.2011.153858
   CARMAN WJ, 1994, AM J EPIDEMIOL, V139, P119, DOI 10.1093/oxfordjournals.aje.a116974
   Cheng CF, 2013, EVID-BASED COMPL ALT, V2013, DOI [10.1155/2013/613950, 10.1155/2013/958025]
   Chinese Medical Association Diabetes Society metabolic syndrome Study Group, 2004, CHINA IND EC, P5
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   CIMMINO MA, 1990, CLIN EXP RHEUMATOL, V8, P251
   Fahmi H, 2011, MOD RHEUMATOL, V21, P1, DOI 10.1007/s10165-010-0347-x
   Findlay DM, 2007, RHEUMATOLOGY, V46, P1763, DOI 10.1093/rheumatology/kem191
   Frey MI, 1996, J RHEUMATOL, V23, P716
   Gandhi R, 2010, J ARTHROPLASTY, V25, P416, DOI 10.1016/j.arth.2009.02.005
   Gkretsi V, 2011, PROG LIPID RES, V50, P133, DOI 10.1016/j.plipres.2010.11.001
   Gosset M, 2008, BIORHEOLOGY, V45, P301, DOI 10.3233/BIR-2008-0494
   Grotle M, 2008, BMC MUSCULOSKEL DIS, V9, DOI 10.1186/1471-2474-9-132
   Grundy SM, 2004, J CLIN ENDOCR METAB, V89, P2595, DOI 10.1210/jc.2004-0372
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Hawker GA, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0091286
   Hochberg MC, 2010, OSTEOARTHR CARTILAGE, V18, pS1, DOI 10.1016/j.joca.2010.04.001
   HOCHBERG MC, 1995, ARTHRITIS RHEUM, V38, P1541, DOI 10.1002/art.1780381104
   Javaid MK, 2010, OSTEOARTHR CARTILAGE, V18, P323, DOI 10.1016/j.joca.2009.11.002
   Jevsevar David S, 2013, J Bone Joint Surg Am, V95, P1885
   Katz JD, 2010, CURR OPIN RHEUMATOL, V22, P512, DOI 10.1097/BOR.0b013e32833bfb4b
   KELLGREN JH, 1952, BRIT J IND MED, V9, P197
   Liu FC, 2011, J CLIN IMMUNOL, V31, P1131, DOI 10.1007/s10875-011-9576-9
   LYSHOLM J, 1982, AM J SPORT MED, V10, P150, DOI 10.1177/036354658201000306
   Masuko K, 2009, CLIN EXP RHEUMATOL, V27, P347
   Nguyen USDT, 2011, ANN INTERN MED, V155, P725, DOI 10.7326/0003-4819-155-11-201112060-00004
   Pottie P, 2006, ANN RHEUM DIS, V65, P1403, DOI 10.1136/ard.2006.061994
   Richmond JC, 2013, RHEUM DIS CLIN N AM, V39, P203, DOI 10.1016/j.rdc.2012.10.008
   Riddle DL, 2013, ORTHOPEDICS, V36, pE25, DOI 10.3928/01477447-20121217-14
   Rosa SC, 2009, ARTHRITIS RES THER, V11, DOI 10.1186/ar2713
   Saudek Deborah M, 2003, Curr Rheumatol Rep, V5, P33, DOI 10.1007/s11926-003-0081-x
   Schett G, 2013, DIABETES CARE, V36, P403, DOI 10.2337/dc12-0924
   Schett G, 2009, ARTHRITIS RHEUM-US, V60, P2381, DOI 10.1002/art.24757
   Sellam J, 2013, JOINT BONE SPINE, V80, P568, DOI 10.1016/j.jbspin.2013.09.007
   Srikanth VK, 2005, OSTEOARTHR CARTILAGE, V13, P769, DOI 10.1016/j.joca.2005.04.014
   Stürmer T, 2001, SCAND J RHEUMATOL, V30, P169
   Velasquez MT, 2010, METAB SYNDR RELAT D, V8, P295, DOI 10.1089/met.2009.0110
   WAINE H, 1961, Tufts Folia Med, V7, P13
   Wang HM, 2010, CHIN J INTEGR MED, V16, P378, DOI 10.1007/s11655-010-0512-2
   Xia W, 2006, J ORTHOP RES, V24, P159, DOI 10.1002/jor.20060
   Yudoh K, 2010, AGING-US, V2, P990, DOI 10.18632/aging.100213
   Yusuf E, 2010, ANN RHEUM DIS, V69, P761, DOI 10.1136/ard.2008.106930
   Zhang YQ, 2010, CLIN GERIATR MED, V26, P355, DOI [10.1016/j.cger.2010.03.001, 10.1016/j.rdc.2012.10.004]
   Zhuo Q, 2012, NAT REV RHEUMATOL, V8, P729, DOI 10.1038/nrrheum.2012.135
NR 46
TC 69
Z9 75
U1 0
U2 22
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2305-5839
EI 2305-5847
J9 ANN TRANSL MED
JI ANN. TRANSL. MED.
PD APR
PY 2016
VL 4
IS 7
AR 133
DI 10.21037/atm.2016.03.48
PG 10
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA DY0NA
UT WOS:000384792300008
PM 27162783
OA Green Published
DA 2025-06-11
ER

PT J
AU Rioli, G
   Tassi, S
   Mattei, G
   Ferrari, S
   Galeazzi, GM
   Mancini, S
   Alboni, S
   Roncucci, L
AF Rioli, Giulia
   Tassi, Silvia
   Mattei, Giorgio
   Ferrari, Silvia
   Galeazzi, Gian Maria
   Mancini, Stefano
   Alboni, Silvia
   Roncucci, Luca
TI The Association Between Symptoms of Anxiety, Depression, and
   Cardiovascular Risk Factors Results From an Italian Cross-Sectional
   Study
SO JOURNAL OF NERVOUS AND MENTAL DISEASE
LA English
DT Article
DE Anxiety; biopsychosocial complexity; cardiovascular risk factors;
   depression; inflammation
ID INTIMA-MEDIA THICKNESS; CORONARY-HEART-DISEASE; HOSPITAL ANXIETY;
   METABOLIC SYNDROME; MENTAL-DISORDERS; HEALTH SURVEY; PREVALENCE; CARE;
   VALIDITY; ADULTS
AB Cardiovascular diseases, anxiety, and depression are among the most frequent clinical conditions in the Western world, often in comorbidity. Evidence regarding a shared pathophysiology suggests a mediating role by chronic systemic inflammation. The aims of this study were to measure the association between anxiety and depressive symptoms, cardiovascular risk factors, and inflammatory markers. Outpatients aged 40 years or more undergoing colonoscopy after positive fecal occult blood test were enrolled; the following data were collected: body mass index, blood pressure, blood glucose, lipid profile, C-reactive protein (CRP) level, carotid thickness, Hospital Anxiety and Depression Scale, Temperament and Character Inventory, INTERdisciplinary MEDicine Self-Assessment, and 36-Item Short-Form Health Survey scores. Fifty-four patients were enrolled; 30.2% had anxiety symptoms, 18.9% depressive symptoms, and 9.4% concomitant anxiety-depressive symptoms. Anxiety symptoms were associated with low high-density lipoprotein levels. Depressive symptoms were associated with CRP levels, providing supporting evidence for the role of inflammation in the pathophysiology of depression.
C1 [Rioli, Giulia; Tassi, Silvia; Mattei, Giorgio; Ferrari, Silvia; Galeazzi, Gian Maria] Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, Modena, Italy.
   [Rioli, Giulia] Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, PhD Program Clin & Expt Med, Modena, Italy.
   [Mattei, Giorgio] Univ Modena & Reggio Emilia, Dept Econ, PhD Program Labour Dev & Innovat, Modena, Italy.
   [Mattei, Giorgio] Marco Biagi Fdn, Modena, Italy.
   [Mattei, Giorgio] Assoc Res Psychiat, Modena, Italy.
   [Ferrari, Silvia; Galeazzi, Gian Maria] Univ Modena & Reggio Emilia, Ctr Neurosci & Neurotechnol, Modena, Italy.
   [Mancini, Stefano; Roncucci, Luca] Univ Modena & Reggio Emilia, Dept Med & Surg Sci, Modena, Italy.
   [Alboni, Silvia] Univ Modena & Reggio Emilia, Dept Life Sci, Modena, Italy.
C3 Universita di Modena e Reggio Emilia; Universita di Modena e Reggio
   Emilia; Universita di Modena e Reggio Emilia; Universita di Modena e
   Reggio Emilia; Universita di Modena e Reggio Emilia; Universita di
   Modena e Reggio Emilia
RP Rioli, G (corresponding author), Univ Modena & Reggio Emilia, Policlin Modena, Clin Psichiat, Via Pozzo 71, I-41124 Modena, Italy.
EM giulyrioli@hotmail.it
RI Ferrari, Silvia/G-5964-2011; Alboni, Silvia/HME-1742-2023; Roncucci,
   Luca/L-1392-2016; Galeazzi, Gian/J-6676-2016; Mancini,
   Stefano/B-1190-2016
OI Galeazzi, Gian/0000-0003-2706-3362; Mancini, Stefano/0000-0002-7350-5603
CR AKIL H, 1993, BIOL PSYCHIAT, V33, P73, DOI 10.1016/0006-3223(93)90305-W
   Andrade LH, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031879
   [Anonymous], 2006, The IDF consensus worldwide definition of the metabolic syndrome
   Apolone G, 1998, J CLIN EPIDEMIOL, V51, P1025, DOI 10.1016/S0895-4356(98)00094-8
   Arija V, 2018, HEALTH QUAL LIFE OUT, V16, DOI 10.1186/s12955-018-1008-6
   Bjelland I, 2002, J PSYCHOSOM RES, V52, P69, DOI 10.1016/S0022-3999(01)00296-3
   Buendia F, 2011, TRANSPL P, V43, P2251, DOI 10.1016/j.transproceed.2011.05.003
   Burbatti G, 1999, IN GUERRA COL CIBO
   Cloninger C.R., 1994, The temperament and character inventory (TCI): A guide to its development and use
   Collino M, 2006, EUR J PHARMACOL, V530, P70, DOI 10.1016/j.ejphar.2005.11.049
   Corrigan PW, 2014, PSYCHOL SCI PUBL INT, V15, P37, DOI 10.1177/1529100614531398
   Costantini M, 1999, SUPPORT CARE CANCER, V7, P121, DOI 10.1007/s005200050241
   Dall TM, 2014, DIABETES CARE, V37, P3172, DOI 10.2337/dc14-1036
   de Girolamo G, 2006, SOC PSYCH PSYCH EPID, V41, P853, DOI 10.1007/s00127-006-0097-4
   Dortland AKBV, 2017, PSYCHOSOM MED, V79, P485, DOI 10.1097/PSY.0000000000000446
   Elovainio M, 2005, PSYCHOSOM MED, V67, P561, DOI 10.1097/01.psy.0000170340.74035.23
   ENGEL GL, 1980, AM J PSYCHIAT, V137, P535
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Fossati A, 2007, COMPR PSYCHIAT, V48, P380, DOI 10.1016/j.comppsych.2007.02.003
   FRASURESMITH N, 1995, HEALTH PSYCHOL, V14, P388, DOI 10.1037/0278-6133.14.5.388
   Gallus S, 2013, PREV MED, V56, P314, DOI 10.1016/j.ypmed.2013.02.009
   Germano G, 2012, EUR HEART J, V33, P137
   Giampaoli S, 2015, EUR J PREV CARDIOL, V22, P9, DOI 10.1177/2047487315589011
   Gnavi R, 2018, NUTR METAB CARDIOVAS, V28, P219, DOI 10.1016/j.numecd.2017.12.004
   Goff David C Jr, 2014, Circulation, V129, pS49, DOI 10.1161/01.cir.0000437741.48606.98
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Grundy SM, 1999, CIRCULATION, V100, P1481, DOI 10.1161/01.CIR.100.13.1481
   Istituto Superiore di Sanita (ISS), 2012, PROG CUOR EP PREV MA
   Italian National Institute of Statistics (ISTAT), 2017, IND STAT MULT FAM AS
   Kollia N, 2017, MATURITAS, V106, P73, DOI 10.1016/j.maturitas.2017.09.005
   Lichtman JH, 2008, CIRCULATION, V118, P1768, DOI 10.1161/CIRCULATIONAHA.108.190769
   Martens EJ, 2010, ARCH GEN PSYCHIAT, V67, P750, DOI 10.1001/archgenpsychiatry.2010.74
   Mattei G, 2018, J NERV MENT DIS, V206, P316, DOI 10.1097/NMD.0000000000000807
   Murray C.J. L., 1996, Burden of Disease: A comprehensive assessment of mortality and disability from diseases, injuries, and risk factors in 1990 and projected to 2020
   Organization W.H., 2017, Depression and other common mental disorders: Global health estimates
   Polak JF, 2011, NEW ENGL J MED, V365, P213, DOI 10.1056/NEJMoa1012592
   Roest AM, 2010, J AM COLL CARDIOL, V56, P38, DOI 10.1016/j.jacc.2010.03.034
   Roth GA, 2015, NEW ENGL J MED, V372, P1333, DOI 10.1056/NEJMoa1406656
   Sajadieh A, 2004, EUR HEART J, V25, P363, DOI 10.1016/j.ehj.2003.12.003
   Santos IS, 2015, ATHEROSCLEROSIS, V240, P529, DOI 10.1016/j.atherosclerosis.2015.04.800
   Seldenrijk A, 2010, J PSYCHOSOM RES, V69, P203, DOI 10.1016/j.jpsychores.2010.01.005
   Severi E, 2018, INT J MENT HEALTH NU, V27, P1002, DOI 10.1111/inm.12407
   Stein JH, 2008, J AM SOC ECHOCARDIOG, V21, P93, DOI 10.1016/j.echo.2007.11.011
   STEIN M, 1985, J IMMUNOL, V135, pS827
   Suls J, 2005, PSYCHOL BULL, V131, P260, DOI 10.1037/0033-2909.131.2.260
   Terluin B, 2009, BMC FAM PRACT, V10, DOI 10.1186/1471-2296-10-58
   Tiemeier H, 2004, ARCH GEN PSYCHIAT, V61, P369, DOI 10.1001/archpsyc.61.4.369
   Tondi L, 2011, DIALOGO FARMACI, V2, P57
   Trenti C, 2009, ITAL J MED, V3, P220, DOI 10.1016/j.itjm.2009.09.003
   Vogel RA, 1997, CLIN CARDIOL, V20, P426, DOI 10.1002/clc.4960200505
   Wang PS, 2007, WORLD PSYCHIATRY, V6, P177
   Ware J.E., 2003, SF 36 HLTH SURVEY MA
   Weinberger AH, 2010, DRUG ALCOHOL DEPEN, V108, P7, DOI 10.1016/j.drugalcdep.2009.11.004
   Wood D, 2001, AM HEART J, V141, pS49, DOI 10.1067/mhj.2001.109951
   World Health Organization, 2008, GLOB BURD DIS 2004 U
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 56
TC 9
Z9 9
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-3018
EI 1539-736X
J9 J NERV MENT DIS
JI J. Nerv. Ment. Dis.
PD MAY
PY 2019
VL 207
IS 5
BP 340
EP 347
DI 10.1097/NMD.0000000000000969
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA HV4HR
UT WOS:000465947900005
PM 30958417
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Lucini, D
   Zanuso, S
   Solaro, N
   Vigo, C
   Malacarne, M
   Pagani, M
AF Lucini, Daniela
   Zanuso, Silvano
   Solaro, Nadia
   Vigo, Chiara
   Malacarne, Mara
   Pagani, Massimo
TI Reducing the risk of metabolic syndrome at the worksite: preliminary
   experience with an ecological approach
SO ACTA DIABETOLOGICA
LA English
DT Article
DE Metabolic syndrome; Prevention; Exercise medicine; Workplace; Lifestyle
ID WORKPLACE HEALTH-PROMOTION; LIFE-STYLE; CARDIOVASCULAR HEALTH;
   SCIENTIFIC STATEMENT; WELLNESS PROGRAMS; PHYSICAL-ACTIVITY; ASSOCIATION;
   PREVENTION; DISEASE; STRESS
AB Given the time spent at work, the workplace represents an ideal setting to implement preventive programs for non-communicable diseases, the major cause of mortality and morbidity in Western and developing countries. We sought to verify if an ecological approach based on corporate culture, employees' education and concrete modifications of workplace environment, offering easy opportunity to assume healthy lifestyle, could be associated with reduced cardiometabolic risk.
   The study involved 1089 workers in two multinational companies following different workplace health promotion policies. Company A offered to all employees the opportunity to access a web platform dedicated to general information on health and diseases. Company B implemented an ecological model encompassing company culture, employees' education and concrete modifications of workplace environment, giving to all employees the opportunity to adopt healthy solutions throughout daily living at workplace. Participants volunteered self-reported clinical information using an IT tool. Numbers of Metabolic Syndrome components (MetS) were taken as proxy of cardiometabolic risk.
   MetS probability obtained via statistical modeling was lower in company B as compared to company A, and absenteeism was also lower in company B. Our study shows that a work environment favoring assumption of healthy lifestyle, as in company B, is associated with a lower percentage of employees with MetS components and lower absenteeism. Moreover, statistical modeling shows that individual probabilities of being without MetS elements, controlling for age and gender, is remarkably higher in company B.
   Our data suggest that ecological approaches might be useful in worksite prevention policies.
C1 [Lucini, Daniela; Vigo, Chiara; Malacarne, Mara; Pagani, Massimo] Univ Milan, BIOMETRA, Milan, Italy.
   [Lucini, Daniela; Vigo, Chiara; Malacarne, Mara] Humanitas Clin & Res Ctr, Sez Med Esercizio & Patol Funz, Via Alessandro Manzoni 56, I-20089 Milan, Italy.
   [Zanuso, Silvano] Univ Greenwich, London SE18 6PF, England.
   [Zanuso, Silvano] Technogym Sci Dept, Cesena, Italy.
   [Solaro, Nadia] Univ Milano Bicocca, Dept Stat & Quantitat Methods, Milan, Italy.
C3 University of Milan; University of Greenwich; University of
   Milano-Bicocca
RP Lucini, D (corresponding author), Univ Milan, BIOMETRA, Milan, Italy.; Lucini, D (corresponding author), Humanitas Clin & Res Ctr, Sez Med Esercizio & Patol Funz, Via Alessandro Manzoni 56, I-20089 Milan, Italy.
EM daniela.lucini@unimi.it
RI Lucini, Daniela/ABD-7517-2021
OI Lucini, Daniela/0000-0003-4845-8988; SOLARO, NADIA/0000-0001-8732-5737
CR Agresti A., 2002, Categorical data analysis., V2, DOI 10.1002/0471249688
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   [Anonymous], LANCET
   Artinian NT, 2010, CIRCULATION, V122, P406, DOI 10.1161/CIR.0b013e3181e8edf1
   Baicker K, 2010, HEALTH AFFAIR, V29, DOI 10.1377/hlthaff.2009.0626
   Bhaskaran K, 2014, LANCET, V384, P755, DOI 10.1016/S0140-6736(14)60892-8
   Bowman A.W., 1997, APPL SMOOTHING TECHN
   Capewell S, 2010, JAMA-J AM MED ASSOC, V304, P2057, DOI 10.1001/jama.2010.1641
   Carnethon M, 2009, CIRCULATION, V120, P1725, DOI 10.1161/CIRCULATIONAHA.109.192653
   Colbert JA, 2013, NEW ENGL J MED, V369, P1389, DOI 10.1056/NEJMp1306460
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Ford ES, 2012, CIRCULATION, V125, P987, DOI 10.1161/CIRCULATIONAHA.111.049122
   Gifi A., 1990, NONLINEAR MULTIVARIA
   Go AS, 2014, CIRCULATION, V129, pE28, DOI 10.1161/01.cir.0000441139.02102.80
   Goetzel RZ, 2014, J OCCUP ENVIRON MED, V56, P927, DOI 10.1097/JOM.0000000000000276
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Hollander M., 1999, Nonparametric Statistical Methods.
   Jones DW, 2009, CIRCULATION, V119, P340, DOI 10.1161/CIRCULATIONAHA.108.191328
   Kaspin LC, 2013, POPUL HEALTH MANAG, V16, P14, DOI 10.1089/pop.2012.0006
   Kushi LH, 2006, CA-CANCER J CLIN, V56, P254, DOI 10.3322/canjclin.56.5.254
   Lloyd-Jones DM, 2010, CIRCULATION, V121, P586, DOI 10.1161/CIRCULATIONAHA.109.192703
   Loeppke RR, 2013, J OCCUP ENVIRON MED, V55, P500, DOI 10.1097/JOM.0b013e31829613a4
   Lucini D, 2005, HYPERTENSION, V46, P1201, DOI 10.1161/01.HYP.0000185147.32385.4b
   Lucini D, 2007, HYPERTENSION, V49, P291, DOI 10.1161/01.HYP.0000255034.42285.58
   Lucini D, 2015, ACTA DIABETOL, V52, P81, DOI 10.1007/s00592-014-0605-z
   Lucini D, 2011, J MED INTERNET RES, V13, DOI 10.2196/jmir.1798
   Lucini D, 2011, EUR J INTERN MED, V22, P363, DOI 10.1016/j.ejim.2011.02.022
   McCullagh P., 2019, GEN LINEAR MODELS, DOI DOI 10.1201/9780203753736
   MCLEROY KR, 1988, HEALTH EDUC QUART, V15, P351, DOI 10.1177/109019818801500401
   Mitchell RJ, 2013, J OCCUP ENVIRON MED, V55, P1142, DOI 10.1097/JOM.0b013e3182a50037
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Niessen MAJ, 2012, J OCCUP ENVIRON MED, V54, P404, DOI 10.1097/JOM.0b013e31824d2e43
   Okie S, 2007, NEW ENGL J MED, V357, P1465, DOI 10.1056/NEJMp078152
   Pearson TA, 2013, CIRCULATION, V127, P1730, DOI 10.1161/CIR.0b013e31828f8a94
   PETERSON B, 1990, J R STAT SOC C-APPL, V39, P205
   Rabacow FM, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-317
   Rongen A, 2013, AM J PREV MED, V44, P406, DOI 10.1016/j.amepre.2012.12.007
   Schultz AB, 2009, J OCCUP ENVIRON MED, V51, P771, DOI 10.1097/JOM.0b013e3181a88da5
   Spring B, 2013, CIRCULATION, V128, P2169, DOI 10.1161/01.cir.0000435173.25936.e1
   Weintraub WS, 2011, CIRCULATION, V124, P967, DOI 10.1161/CIR.0b013e3182285a81
   Wickham H, 2009, USE R, P1, DOI 10.1007/978-0-387-98141-3
   Wierenga D, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-1190
   Wright DW, 2002, J OCCUP ENVIRON MED, V44, P1126, DOI 10.1097/00043764-200212000-00006
NR 43
TC 7
Z9 9
U1 0
U2 17
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD FEB
PY 2016
VL 53
IS 1
BP 63
EP 71
DI 10.1007/s00592-015-0744-x
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DD6MI
UT WOS:000370037900009
PM 25863782
DA 2025-06-11
ER

PT J
AU Lamers, F
   Vogelzangs, N
   Merikangas, KR
   de Jonge, P
   Beekman, ATF
   Penninx, BWJH
AF Lamers, F.
   Vogelzangs, N.
   Merikangas, K. R.
   de Jonge, P.
   Beekman, A. T. F.
   Penninx, B. W. J. H.
TI Evidence for a differential role of HPA-axis function, inflammation and
   metabolic syndrome in melancholic versus atypical depression
SO MOLECULAR PSYCHIATRY
LA English
DT Article
DE depression; inflammation; metabolic syndrome; salivary cortisol;
   subtypes
ID MAJOR DEPRESSION; SALIVARY CORTISOL; ANTIDEPRESSANT USE; ANXIETY;
   CYTOKINES; ASSOCIATIONS; NETHERLANDS; SYMPTOMS; SUBTYPES; MOOD
AB The hypothalamic-pituitary-adrenal (HPA) axis and the inflammatory response system have been suggested as pathophysiological mechanisms implicated in the etiology of major depressive disorder (MDD). Although meta-analyses do confirm associations between depression and these biological systems, effect sizes vary greatly among individual studies. A potentially important factor explaining variability is heterogeneity of MDD. Aim of this study was to evaluate the association between depressive subtypes (based on latent class analysis) and biological measures. Data from 776 persons from the Netherlands Study of Depression and Anxiety, including 111 chronic depressed persons with melancholic depression, 122 with atypical depression and 543 controls were analyzed. Inflammatory markers (C-reactive protein, interleukin-6, tumor necrosis factor-alpha), metabolic syndrome components, body mass index (BMI), saliva cortisol awakening curves (area under the curve with respect to the ground (AUCg) and with respect to the increase (AUCi)), and diurnal cortisol slope were compared among groups. Persons with melancholic depression had a higher AUCg and higher diurnal slope compared with persons with atypical depression and with controls. Persons with atypical depression had significantly higher levels of inflammatory markers, BMI, waist circumference and triglycerides, and lower high-density lipid cholesterol than persons with melancholic depression and controls. This study confirms that chronic forms of the two major subtypes of depression are associated with different biological correlates with inflammatory and metabolic dysregulation in atypical depression and HPA-axis hyperactivity in melancholic depression. The data provide further evidence that chronic forms of depressive subtypes differ not only in their symptom presentation, but also in their biological correlates. These findings have important implications for future research on pathophysiological pathways of depression and treatment.
C1 [Lamers, F.; Merikangas, K. R.] NIMH, Genet Epidemiol Res Branch, Intramural Res Program, NIH, Bethesda, MD 20892 USA.
   [Vogelzangs, N.; Beekman, A. T. F.; Penninx, B. W. J. H.] Vrije Univ Amsterdam Med Ctr, Dept Psychiat EMGO, Inst Hlth & Care Res, Amsterdam, Netherlands.
   [de Jonge, P.; Penninx, B. W. J. H.] Univ Groningen, Univ Med Ctr Groningen, ICPE, Dept Psychiat, Groningen, Netherlands.
   [de Jonge, P.; Penninx, B. W. J. H.] Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Groningen, Netherlands.
   [Penninx, B. W. J. H.] Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Mental Health (NIMH); Vrije Universiteit Amsterdam; VU UNIVERSITY
   MEDICAL CENTER; University of Groningen; University of Groningen; Leiden
   University - Excl LUMC; Leiden University; Leiden University Medical
   Center (LUMC)
RP Lamers, F (corresponding author), NIMH, Genet Epidemiol Res Branch, Intramural Res Program, NIH, 35 Convent Dr,Room 1A108, Bethesda, MD 20892 USA.
EM lamersf@mail.nih.gov
RI Beekman, Aartjan T./LUZ-6919-2024; Lamers, Femke/G-5161-2012; Penninx,
   Brenda/S-7627-2017; de Jonge, Peter/L-6395-2013
OI Lamers, Femke/0000-0003-4344-5766; de Jonge, Peter/0000-0002-0866-6929;
   Merikangas, Kathkeen/0000-0002-4667-2414
FU Geestkracht program of the Netherlands Organisation for Health Research
   and Development (Zon-Mw) [10-000-1002]; VU University Medical Center;
   GGZ inGeest; Arkin; Leiden University Medical Center; GGZ Rivierduinen;
   University Medical Center Groningen; Lentis; GGZ Friesland; GGZ Drenthe;
   Scientific Institute for Quality of Healthcare (IQ healthcare);
   Netherlands Institute for Health Services Research (NIVEL); Netherlands
   Institute of Mental Health and Addiction (Trimbos); Neuroscience Campus
   Amsterdam; Netherlands Organisation for Scientific research (VIDI
   project); Rubicon fellowship from the Netherlands Organisation for
   Scientific research; National Institute of Mental Health, Genetic
   Epidemiology Research Branch; VICI grant from the Netherlands
   Organisation for Scientific research
FX The infrastructure for the NESDA study (www.nesda.nl) is funded through
   the Geestkracht program of the Netherlands Organisation for Health
   Research and Development (Zon-Mw, grant number 10-000-1002) and is
   supported by participating universities and mental health care
   organizations (VU University Medical Center, GGZ inGeest, Arkin, Leiden
   University Medical Center, GGZ Rivierduinen, University Medical Center
   Groningen, Lentis, GGZ Friesland, GGZ Drenthe, Scientific Institute for
   Quality of Healthcare (IQ healthcare), Netherlands Institute for Health
   Services Research (NIVEL) and Netherlands Institute of Mental Health and
   Addiction (Trimbos). Biomarker funding was provided by the Neuroscience
   Campus Amsterdam and the Netherlands Organisation for Scientific
   research (VIDI project). BWJHP is supported by a VICI grant from the
   Netherlands Organisation for Scientific research. FL is supported by a
   Rubicon fellowship from the Netherlands Organisation for Scientific
   research and by a Supplemental Intramural Research Training Award from
   the National Institute of Mental Health, Genetic Epidemiology Research
   Branch. The views and opinions expressed in this article are ours and
   should not be construed to represent the views of any of the sponsoring
   organizations, agencies or US Government.
CR Alesci S, 2005, J CLIN ENDOCR METAB, V90, P2522, DOI 10.1210/jc.2004-1667
   Angst J, 2006, EUR ARCH PSY CLIN N, V256, P44, DOI 10.1007/s00406-005-0600-z
   Angst J, 2002, J AFFECT DISORDERS, V72, P125, DOI 10.1016/S0165-0327(02)00169-6
   Anisman H, 1999, MOL PSYCHIATR, V4, P182, DOI 10.1038/sj.mp.4000436
   [Anonymous], PSYCHOL MED
   [Anonymous], 1997, COMP INT DIAGN INT C
   Antonijevic I, 2008, STRESS, V11, P15, DOI 10.1080/10253890701378967
   Armitage R, 2007, ACTA PSYCHIAT SCAND, V115, P104, DOI 10.1111/j.1600-0447.2007.00968.x
   Capuron L, 2008, BIOL PSYCHIAT, V64, P896, DOI 10.1016/j.biopsych.2008.05.019
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Dortland AKBV, 2010, ACTA PSYCHIAT SCAND, V122, P30, DOI 10.1111/j.1600-0447.2010.01565.x
   Dortland AKBV, 2010, J CLIN PSYCHIAT, V71, P729, DOI 10.4088/JCP.08m04865blu
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Vázquez-Vela MEF, 2008, ARCH MED RES, V39, P715, DOI 10.1016/j.arcmed.2008.09.005
   Fyer AJ, 1999, AM J MED GENET, V88, P173, DOI 10.1002/(SICI)1096-8628(19990416)88:2<173::AID-AJMG15>3.3.CO;2-R
   GILES DE, 1986, BIOL PSYCHIAT, V21, P473, DOI 10.1016/0006-3223(86)90189-7
   Gimeno D, 2009, PSYCHOL MED, V39, P413, DOI 10.1017/S0033291708003723
   Gold PW, 2002, MOL PSYCHIATR, V7, P254, DOI 10.1038/sj.mp.4001032
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Harald B, 2012, J AFFECT DISORDERS, V139, P126, DOI 10.1016/j.jad.2011.07.015
   Hasler G, 2004, PSYCHOL MED, V34, P1047, DOI 10.1017/S0033291703001697
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Huang TL, 2007, PSYCHIAT CLIN NEUROS, V61, P415, DOI 10.1111/j.1440-1819.2007.01686.x
   Jabben N, 2011, J PSYCHIATR RES, V45, P1208, DOI 10.1016/j.jpsychires.2011.03.010
   Jo YH, 2002, J NEUROBIOL, V53, P618, DOI 10.1002/neu.10147
   Kaestner F, 2005, J AFFECT DISORDERS, V87, P305, DOI 10.1016/j.jad.2005.03.012
   Kahl KG, 2012, EUR ARCH PSY CLIN N, V262, P313, DOI 10.1007/s00406-011-0277-4
   Karlovic D, 2012, PSYCHIAT RES, V198, P74, DOI 10.1016/j.psychres.2011.12.007
   KIRSCHBAUM C, 1994, PSYCHONEUROENDOCRINO, V19, P313, DOI 10.1016/0306-4530(94)90013-2
   Knorr U, 2010, PSYCHONEUROENDOCRINO, V35, P1275, DOI 10.1016/j.psyneuen.2010.04.001
   Lamers F, 2010, J CLIN PSYCHIAT, V71, P1582, DOI 10.4088/JCP.09m05398blu
   Levinson DF, 2003, AM J MED GENET B, V119B, P118, DOI 10.1002/ajmg.b.20009
   Licht CMM, 2009, HYPERTENSION, V53, P631, DOI 10.1161/HYPERTENSIONAHA.108.126698
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   LYKETSOS CG, 1994, INT J METHOD PSYCH, V4, P143
   Maes M, 2011, PROG NEURO-PSYCHOPH, V35, P664, DOI 10.1016/j.pnpbp.2010.06.014
   Manthey L, 2011, EUR NEUROPSYCHOPHARM, V21, P691, DOI 10.1016/j.euroneuro.2011.03.002
   McKay MS, 2010, J PSYCHIATR RES, V44, P183, DOI 10.1016/j.jpsychires.2009.07.012
   Mendlewicz J, 2006, INT CLIN PSYCHOPHARM, V21, P227, DOI 10.1097/00004850-200607000-00005
   Miller AH, 2009, BIOL PSYCHIAT, V65, P732, DOI 10.1016/j.biopsych.2008.11.029
   Miller GE, 2002, AM J CARDIOL, V90, P1279, DOI 10.1016/S0002-9149(02)02863-1
   Monroe SM, 2012, PSYCHOL MED, V42, P899, DOI 10.1017/S0033291711002066
   Monroe SM, 2011, PSYCHOL REV, V118, P655, DOI 10.1037/a0025190
   Müller N, 2006, MOL PSYCHIATR, V11, P680, DOI 10.1038/sj.mp.4001805
   Papakostas GI, 2004, EUR NEUROPSYCHOPHARM, V14, P135, DOI 10.1016/S0924-977X(03)00099-3
   Parker G, 2002, AM J PSYCHIAT, V159, P1470, DOI 10.1176/appi.ajp.159.9.1470
   Penninx BWJH, 2008, INT J METH PSYCH RES, V17, P121, DOI 10.1002/mpr.256
   Posternak MA, 2002, ARCH GEN PSYCHIAT, V59, P70, DOI 10.1001/archpsyc.59.1.70
   Pruessner JC, 2003, PSYCHONEUROENDOCRINO, V28, P916, DOI 10.1016/S0306-4530(02)00108-7
   Raedler TJ, 2011, CURR OPIN PSYCHIATR, V24, P519, DOI 10.1097/YCO.0b013e32834b9db6
   Raison CL, 2006, TRENDS IMMUNOL, V27, P24, DOI 10.1016/j.it.2005.11.006
   Reichenberg A, 2001, ARCH GEN PSYCHIAT, V58, P445, DOI 10.1001/archpsyc.58.5.445
   Rush AJ, 1996, PSYCHOL MED, V26, P477, DOI 10.1017/S0033291700035558
   Shelton RC, 2010, PROG NEUROBIOL, V91, P275, DOI 10.1016/j.pneurobio.2010.04.004
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Stetler C, 2011, PSYCHOSOM MED, V73, P114, DOI 10.1097/PSY.0b013e31820ad12b
   Sullivan PF, 2002, J AFFECT DISORDERS, V68, P273, DOI 10.1016/S0165-0327(00)00364-5
   Sullivan PF, 1998, AM J PSYCHIAT, V155, P1398, DOI 10.1176/ajp.155.10.1398
   Thase ME, 2009, NEUROPSYCHOPHARMACOL, V34, P2633, DOI 10.1038/npp.2009.100
   van Aken MO, 2003, CLIN CHEM, V49, P1408, DOI 10.1373/49.8.1408
   Vogelzangs N, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.8
   Vreeburg SA, 2009, PSYCHONEUROENDOCRINO, V34, P1109, DOI 10.1016/j.psyneuen.2009.04.024
   Wong ML, 2000, P NATL ACAD SCI USA, V97, P325, DOI 10.1073/pnas.97.1.325
   Wright CE, 2005, BRAIN BEHAV IMMUN, V19, P345, DOI 10.1016/j.bbi.2004.10.003
   Yoon HK, 2012, NORD J PSYCHIAT, V66, P183, DOI 10.3109/08039488.2011.611894
NR 65
TC 530
Z9 580
U1 1
U2 146
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD JUN
PY 2013
VL 18
IS 6
BP 692
EP 699
DI 10.1038/mp.2012.144
PG 8
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA 151HP
UT WOS:000319451600011
PM 23089630
DA 2025-06-11
ER

PT J
AU Sasváriová, M
   Salvaras, L
   Seckárová Micháliková, D
   Tyukos Kaprinay, B
   Knezl, V
   Gáspárová, Z
   Stankovicová, T
AF Sasvariova, Michaela
   Salvaras, Lazaros
   Seckarova Michalikova, Dominika
   Tyukos Kaprinay, Barbara
   Knezl, Vladimir
   Gasparova, Zdenka
   Stankovicova, Tatiana
TI Assessment of the Cardiovascular Risk of High-Fat-High-Fructose Diet in
   Hereditary Hypertriacylglycerolemic Rats and Venlafaxine Effect
SO PHYSIOLOGICAL RESEARCH
LA English
DT Article
DE Metabolic syndrome; Venlafaxine; ECG; Cardiac contraction;
   Ischemia/Reperfusion
ID METABOLIC SYNDROME; EXPRESSION; MYOSIN; HEAVY; MODEL; PGC-1-ALPHA;
   PREVALENCE; RECEPTOR; DISEASE; STRESS
AB Metabolic syndrome (MetS) represents a worldwide health problem, affecting cardiovascular and mental health. People with MetS are often suffering from depression. We used hereditary hypertriacylglycerolemic (HTG) rats as an animal model of MetS, and these were fed a high-fat-high-fructose diet (HFFD) to imitate unhealthy eating habits of people having several MetS risk factors and suffering depression. Male HTG rats were fed a standard diet (HTG-SD) or HFFD for eight weeks (HFFD8). Venlafaxine was administered for the last three weeks of the experiment (HFFD8+VE). Heart function was observed on the level of intact organisms (standard ECG in vivo), isolated hearts (perfusion according to Langendorff ex vivo), and molecular level, using the RT-PCR technique. The function of the isolated perfused heart was monitored under baseline and ischemia/reperfusion conditions. Analysis of ECG showed electrical abnormalities in vivo, such significant QRS complex prolongation and increased heart rate. vivo venlafaxine significantly reduced QT interval after ischemia/reperfusion injury. Baseline values of contractile abilities of the heart tended to be suppressed by HFFD. A significant reduction of LVDP was present in the HFFD8 group. Molecular analysis of specific genes involved in cardiac electrical (Cacna1c, Scn5a), contractile (Myh6, Myh7), metabolic function (Pgc1 alpha) and calcium handling (Serca2a, Ryr2) supported some of the functional findings in vivo and ex vivo. Based on the present effect venlafaxine on heart function, further research is needed regarding its cardiometabolic safety in the treatment of patients with MetS suffering from depression.
C1 [Sasvariova, Michaela; Salvaras, Lazaros; Stankovicova, Tatiana] Comenius Univ, Fac Pharm, Dept Pharmacol & Toxicol, Odbojarov 10, Bratislava 83232, Slovakia.
   [Seckarova Michalikova, Dominika; Tyukos Kaprinay, Barbara; Knezl, Vladimir; Gasparova, Zdenka] Slovak Acad Sci, Ctr Expt Med, Inst Expt Pharmacol & Toxicol, Bratislava, Slovakia.
C3 Comenius University Bratislava; Slovak Academy of Sciences; Institute of
   Experimental Pharmacology & Toxicology, SAS; Centre of Experimental
   Medicine, SAS
RP Stankovicová, T (corresponding author), Comenius Univ, Fac Pharm, Dept Pharmacol & Toxicol, Odbojarov 10, Bratislava 83232, Slovakia.
EM stankovicova@fpharm.uniba.sk
FU Slovak Republic [VEGA 2/0018/23, APVV-22-0541, APVV-19-0435]
FX This work was supported by the Scientific Grant Agency of the Ministry
   of Education, Science, Research and Sportthe Slovak Republic VEGA
   2/0018/23, APVV-22-0541, and APVV-19-0435.r the Slovak Republic VEGA
   2/0018/23, APVV-22-0541, and APVV-19-0435.
CR Abozguia K, 2006, J Cardiol, V113, P9, DOI [10.1016/j.ijcard.2006.01.072, DOI 10.1016/J.IJCARD.2006.01.072]
   Akbaraly TN, 2009, DIABETES CARE, V32, P499, DOI 10.2337/dc08-1358
   Alosaimi FD, 2017, GEN HOSP PSYCHIAT, V45, P62, DOI 10.1016/j.genhosppsych.2016.12.007
   Arany Z, 2005, CELL METAB, V1, P259, DOI 10.1016/j.cmet.2005.03.002
   Aromolaran AS, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00431
   Aromolaran AS, 2016, BIOCHEM BIOPH RES CO, V474, P554, DOI 10.1016/j.bbrc.2016.04.113
   Axelsen LN, 2015, CARDIOVASC DIABETOL, V14, DOI 10.1186/s12933-015-0246-8
   Balderas-Villalobos J, 2013, AM J PHYSIOL-HEART C, V305, pH1344, DOI 10.1152/ajpheart.00211.2013
   Battiprolu Pavan K, 2010, Drug Discov Today Dis Mech, V7, pe135
   Behlke LM, 2020, J CLIN PSYCHOPHARM, V40, P553, DOI 10.1097/JCP.0000000000001287
   Berk M, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-200
   Blythe D, 1999, HUM EXP TOXICOL, V18, P309, DOI 10.1191/096032799678840165
   Dincer UD, 2012, DIABETES METAB SYNDR, V5, P89, DOI 10.2147/DMSO.S30005
   Dong F, 2007, DIABETES, V56, P2201, DOI 10.2337/db06-1596
   Durak A, 2017, CAN J PHYSIOL PHARM, V95, P1335, DOI 10.1139/cjpp-2017-0054
   Dzikowicz DJ, 2019, ANN NONINVAS ELECTRO, V24, DOI 10.1111/anec.12665
   England J, 2013, CELL MOL LIFE SCI, V70, P1221, DOI 10.1007/s00018-012-1131-1
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Gaur V, 2010, BRAIN RES, V1353, P204, DOI 10.1016/j.brainres.2010.07.004
   Goldstein MR, 2010, MED HYPOTHESES, V74, P955, DOI 10.1016/j.mehy.2009.11.041
   Hidalgo Isabel, 2022, Cardiovasc. metab. sci, V33, P134, DOI 10.35366/107628
   Ho YL, 2003, J AM SOC ECHOCARDIOG, V16, P931, DOI 10.1016/S0894-7317(03)00424-3
   Kaprinay B, 2016, PHYSIOL RES, V65, pS515, DOI 10.33549/physiolres.933524
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Khalifa M, 1999, J PHARMACOL EXP THER, V291, P280
   Khurana RN, 2003, AM J MED, V115, P676, DOI 10.1016/S0002-9343(03)00472-8
   Král'ová E, 2008, PHYSIOL RES, V57, pS83, DOI 10.33549/physiolres.931556
   Lamounier-Zepter V, 2009, CIRC RES, V105, P326, DOI 10.1161/CIRCRESAHA.109.200501
   Lieve KV, 2017, INT J CARDIOL, V236, P187, DOI 10.1016/j.ijcard.2017.01.113
   Locher MR, 2011, AM J PHYSIOL-HEART C, V300, pH869, DOI 10.1152/ajpheart.00452.2010
   Miyata S, 2000, CIRC RES, V86, P386, DOI 10.1161/01.RES.86.4.386
   Pucci G, 2017, PHARMACOL RES, V120, P34, DOI 10.1016/j.phrs.2017.03.008
   Pyykkönen AJ, 2012, ANN MED, V44, P279, DOI 10.3109/07853890.2010.543921
   Sahraoui A, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0148117
   St-Pierre J, 2003, J BIOL CHEM, V278, P26597, DOI 10.1074/jbc.M301850200
   Teodorescu C, 2011, HEART RHYTHM, V8, P1562, DOI 10.1016/j.hrthm.2011.06.011
   Uguz F, 2015, GEN HOSP PSYCHIAT, V37, P46, DOI 10.1016/j.genhosppsych.2014.10.011
   VRANA A, 1990, TRANSPLANT P, V22, P2579
   Wang CH, 2016, BEHAV BRAIN FUNCT, V12, DOI 10.1186/s12993-016-0116-x
   Wang YM, 2011, HUM PSYCHOPHARM CLIN, V26, P95, DOI 10.1002/hup.1177
   Zicha J, 2006, PHYSIOL RES, V55, pS49, DOI 10.33549/physiolres.930000.55.S1.49
NR 41
TC 1
Z9 1
U1 0
U2 0
PU ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
PI PRAGUE 4
PA VIDENSKA 1083, PRAGUE 4 142 20, CZECH REPUBLIC
SN 0862-8408
EI 1802-9973
J9 PHYSIOL RES
JI Physiol. Res.
PD DEC
PY 2024
VL 73
IS 6
BP 973
EP 984
DI 10.33549/physiolres.935420
PG 12
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA Y0V9A
UT WOS:001429422800007
PM 39903888
OA gold
DA 2025-06-11
ER

PT J
AU Virtanen, M
   Ferrie, JE
   Akbaraly, T
   Tabak, A
   Jokela, M
   Ebmeier, KP
   Singh-Manoux, A
   Kivimäki, M
AF Virtanen, Marianna
   Ferrie, Jane E.
   Akbaraly, Tasnime
   Tabak, Adam
   Jokela, Markus
   Ebmeier, Klaus P.
   Singh-Manoux, Archana
   Kivimaki, Mika
TI Metabolic Syndrome and Symptom Resolution in Depression: A 5-Year
   Follow-Up of Older Adults
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID WHITEHALL-II; ANXIETY DISORDERS; HDL-CHOLESTEROL; LATER LIFE; COHORT;
   RISK; METAANALYSIS; ASSOCIATION; PREVALENCE; DISEASE
AB Objective: Although metabolic syndrome is associated with the incidence of depression, little is known about its contribution to the course of depression. We examined whether metabolic syndrome and its components are associated with long-term symptom resolution in older adults with depressive symptoms.
   Methods: Data from 965 participants in the Whitehall II cohort study (mean age = 62 years at baseline) were used to generate 1,172 person-observations of metabolic syndrome and its components (abdominal obesity, low level of high-density lipoprotein [HDL] cholesterol, high level of triglycerides, hypertension, and elevated fasting glucose or diabetes). All participants were depression cases at the beginning of 2 consecutive follow-up cycles: from 2002-2004 to 2007-2009 and from 2007-2009 to 2012-2013 (mean follow-up = 4.6 years). Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression scale caseness at the beginning and the end of the 2 cycles.
   Results: In multivariable adjusted analyses, metabolic syndrome per se was not associated with symptom resolution. Of its components, low HDL cholesterol (risk ratio [RR] = 0.82; 95% CI, 0.68-1.00; P = .045) and high triglyceride levels (RR = 0.81; 95% CI, 0.70-0.95; P = .007) were associated with a lower likelihood of symptom resolution. These findings were replicated in a subpopulation without coronary heart disease and stroke (RR = 0.77 [95% CI, 0.63-0.95; P = .015] for low HDL cholesterol; RR = 0.79 [95% CI, 0.67-0.94; P = .006] for high triglycerides).
   Conclusions: Low HDL cholesterol and high triglyceride levels are associated with lower likelihood of long-term symptom resolution in depression. These data suggest that an adverse lipid profile, but not other components of metabolic syndrome, may delay recovery from depression.
C1 [Virtanen, Marianna] Finnish Inst Occupat Hlth, Topeliuksenkatu 41 A, Helsinki 00250, Finland.
   [Ferrie, Jane E.; Akbaraly, Tasnime; Tabak, Adam; Singh-Manoux, Archana; Kivimaki, Mika] UCL, Dept Epidemiol & Publ Hlth, London, England.
   [Ferrie, Jane E.] Univ Bristol, Sch Social & Community Med, Bristol, Avon, England.
   [Akbaraly, Tasnime] INSERM, U1198, Montpellier, France.
   [Akbaraly, Tasnime] Ecole Prat Hautes Etud, Paris, France.
   [Akbaraly, Tasnime] Univ Montpellier, Dept Mol Mech Neurodegenerat Dis, Montpellier, France.
   [Tabak, Adam] Semmelweis Univ, Fac Med, Dept Med 1, Budapest, Hungary.
   [Jokela, Markus] Univ Helsinki, Inst Behav Sci, Helsinki, Finland.
   [Ebmeier, Klaus P.] Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford, England.
   [Singh-Manoux, Archana] AP HP, INSERM, U1018, Villejuif, France.
   [Kivimaki, Mika] Univ Helsinki, Fac Med, Dept Publ Hlth, Helsinki, Finland.
C3 Finnish Institute of Occupational Health; University of London;
   University College London; University of Bristol; Institut National de
   la Sante et de la Recherche Medicale (Inserm); Universite de
   Montpellier; Universite PSL; Ecole Pratique des Hautes Etudes (EPHE);
   Universite de Montpellier; Semmelweis University; University of
   Helsinki; University of Oxford; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Paris Saclay; Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Paul-Brousse -
   APHP; University of Helsinki
RP Virtanen, M (corresponding author), Finnish Inst Occupat Hlth, Topeliuksenkatu 41 A, Helsinki 00250, Finland.
EM marianna.virtanen@ttl.fi
RI Tabak, Adam/A-5007-2012; Kivimaki, Mika/B-3607-2012; Ebmeier,
   Klaus/B-4789-2008; Ferrie, Jane/AAZ-2009-2020; Akbaraly,
   Tasnime/H-1389-2018; Jokela, Markus/A-4669-2009; Singh-Manoux,
   Archana/F-6804-2013
OI Tabak, Adam/0000-0002-6234-3936; Akbaraly, Tasnime/0000-0002-2150-4190;
   Jokela, Markus/0000-0003-0117-0012; Kivimaki, Mika/0000-0002-4699-5627;
   Singh-Manoux, Archana/0000-0002-1244-5037; Ebmeier, Klaus
   P./0000-0002-5190-7038
FU Medical Research Council [K013351]; British Heart Foundation; National
   Heart, Lung, and Blood Institute, National Institutes of Health (NIH)
   [R01HL036310]; National Institute of Aging, NIH [R01AG013196,
   R01AG034454]; Academy of Finland [258598, 292824, G1001354]; National
   Heart, Lung, and Blood Institute [R01HL036310]; NIH [R01HL036310,
   R01AG034454]; NordForsk [75021]; Economic and Social Research Council;
   ESRC [ES/J023299/1] Funding Source: UKRI; MRC [G1001354, MR/K013351/1]
   Funding Source: UKRI
FX The Whitehall II Study is supported by grants from the Medical Research
   Council (K013351); British Heart Foundation; National Heart, Lung, and
   Blood Institute, National Institutes of Health (NIH) (R01HL036310); and
   the National Institute of Aging, NIH (R01AG013196 and R01AG034454). Dr
   Virtanen is supported by the Academy of Finland (258598, 292824). Dr
   Ebmeier is supported by the Medical Research Council (G1001354), Dr
   Akbaraly by the National Heart, Lung, and Blood Institute (R01HL036310),
   and Dr Singh-Manoux by the National Institute of Aging, NIH (R01AG013196
   and R01AG034454). Dr Kivimaki is supported by the Medical Research
   Council (K013351), the NIH (R01HL036310, R01AG034454), NordForsk
   (75021), and a professorial fellowship from the Economic and Social
   Research Council.
CR Akbaraly TN, 2011, DIABETES CARE, V34, P904, DOI 10.2337/dc10-1644
   Akbaraly TN, 2009, DIABETES CARE, V32, P499, DOI 10.2337/dc08-1358
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Almeida OP, 2014, MOL PSYCHIATR, V19, P637, DOI 10.1038/mp.2013.113
   Baldwin RC, 2006, INT J GERIATR PSYCH, V21, P57, DOI 10.1002/gps.1424
   Blazer DG, 2005, PSYCHOL MED, V35, P1241, DOI 10.1017/S0033291705004411
   Blazer DG, 2003, J GERONTOL A-BIOL, V58, P249
   Britton A, 2012, BMC MED RES METHODOL, V12, DOI 10.1186/1471-2288-12-83
   Byers AL, 2010, ARCH GEN PSYCHIAT, V67, P489, DOI 10.1001/archgenpsychiatry.2010.35
   De Berardis Domenico, 2012, ISRN Psychiatry, V2012, P387901, DOI 10.5402/2012/387901
   Hamer M, 2011, AM J GERIAT PSYCHIAT, V19, P72, DOI 10.1097/JGP.0b013e3181df465e
   Hardeveld F, 2010, ACTA PSYCHIAT SCAND, V122, P184, DOI 10.1111/j.1600-0447.2009.01519.x
   Heikkilä K, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0040101
   Heiss G, 2014, DIABETES CARE, V37, P2391, DOI 10.2337/dc13-2505
   Katon WJ, 2003, ARCH GEN PSYCHIAT, V60, P897, DOI 10.1001/archpsyc.60.9.897
   Kivimäki M, 2014, MOL PSYCHIATR, V19, P149, DOI 10.1038/mp.2013.35
   Lehto SM, 2010, PSYCHIAT CLIN NEUROS, V64, P279, DOI 10.1111/j.1440-1819.2010.02079.x
   Marmot M, 2005, INT J EPIDEMIOL, V34, P251, DOI 10.1093/ije/dyh372
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Murphy AJ, 2009, CURR MED CHEM, V16, P667, DOI 10.2174/092986709787458425
   Murray CJL, 2012, LANCET, V380, P2197, DOI 10.1016/S0140-6736(12)61729-2
   Nordestgaard BG, 2014, LANCET, V384, P626, DOI 10.1016/S0140-6736(14)61177-6
   Nousen EK, 2013, NEUROENDOCRINOLOGY, V98, P254, DOI 10.1159/000355632
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Papakostas GI, 2004, EUR NEUROPSYCHOPHARM, V14, P135, DOI 10.1016/S0924-977X(03)00099-3
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Richards D, 2011, CLIN PSYCHOL REV, V31, P1117, DOI 10.1016/j.cpr.2011.07.004
   Roaldset JO, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/1471-244X-14-54
   Robinson OJ, 2008, PSYCHOL MED, V38, P315, DOI 10.1017/S0033291707001249
   Santos M, 2009, BRAIN RES REV, V62, P19, DOI 10.1016/j.brainresrev.2009.08.003
   Tabák AG, 2014, LANCET DIABETES ENDO, V2, P236, DOI 10.1016/S2213-8587(13)70139-6
   Tabák AG, 2009, LANCET, V373, P2215, DOI 10.1016/S0140-6736(09)60619-X
   Taylor WD, 2013, MOL PSYCHIATR, V18, P963, DOI 10.1038/mp.2013.20
   TUNSTALLPEDOE H, 1994, CIRCULATION, V90, P583, DOI 10.1161/01.CIR.90.1.583
   Valkanova V, 2013, BIOL PSYCHIAT, V73, P406, DOI 10.1016/j.biopsych.2012.10.028
   Vogelzangs N, 2014, NEUROPSYCHOPHARMACOL, V39, P1624, DOI 10.1038/npp.2014.9
   Vogelzangs N, 2011, J CLIN PSYCHIAT, V72, P598, DOI 10.4088/JCP.10m06559
   World Health Organization International Diabetes Foundation, 2006, INT DIAB FDN DEF DIA
NR 38
TC 27
Z9 30
U1 0
U2 9
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD JAN
PY 2017
VL 78
IS 1
BP E1
EP E7
DI 10.4088/JCP.15m10399
PG 7
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA EN9OX
UT WOS:000396330600001
PM 28129497
DA 2025-06-11
ER

PT J
AU Berger, I
   Werdermann, M
   Bornstein, SR
   Steenblock, C
AF Berger, Ilona
   Werdermann, Martin
   Bornstein, Stefan R.
   Steenblock, Charlotte
TI The adrenal gland in stress - Adaptation on a cellular level
SO JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
LA English
DT Review
DE Adrenal; Medulla; Cortex; Stress; Animal models
ID CHRONIC PSYCHOSOCIAL STRESS; ADVERSE CHILDHOOD EXPERIENCES; SOCIAL
   DEFEAT; STEM-CELLS; DEHYDROEPIANDROSTERONE-SULFATE; PSYCHOLOGICAL
   STRESS; CORTISOL SECRETION; METABOLIC SYNDROME; BLOOD-PRESSURE;
   ANIMAL-MODEL
AB Human individuals are constantly confronted to various kinds of stressors and the body's response and adaptation is essential for human health. The adrenal gland as the main producer of stress hormones plays a major role in the response to physiological challenges and is able to adapt to these physiological needs. Proper adaptation is of particular importance since dysregulation of the stress system is the cause of various human diseases including obesity, depression, Parkinson's disease, and post-traumatic stress disorder. Therefore, it is fundamental to understand the physiological, cellular, and molecular underpinnings of the stress adaptation in humans. Because of ethical reasons it is problematic to study the plasticity of the human gland in stress. Hence, various experimental models have been established for the analysis of the functional and cellular role of the adrenal gland adaptation on a translational approach. Here, we summarize the insights of stress-induced adrenal plasticity gained from these models and discuss their relevance to clinical observations.
C1 [Berger, Ilona; Werdermann, Martin; Bornstein, Stefan R.; Steenblock, Charlotte] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Internal Med 3, D-01307 Dresden, Germany.
   [Bornstein, Stefan R.] Kings Coll London, Diabet & Nutr Sci Div, London WC2R 2LS, England.
C3 Technische Universitat Dresden; Carl Gustav Carus University Hospital;
   University of London; King's College London
RP Steenblock, C (corresponding author), Tech Univ Dresden, Dept Internal Med 3, Fetscherstr 74, D-01307 Dresden, Germany.
EM charlotte.steenblock@uniklinikum-dresden.de
RI Steenblock, Charlotte/C-9038-2018
OI Berger, Ilona/0000-0001-6362-5903; Steenblock,
   Charlotte/0000-0002-9635-4860
FU Deutsche Forschungsgemeinschaft (DFG) [CRC/Transregio 205/1, IRTG2251]
FX This study was supported by the Deutsche Forschungsgemeinschaft (DFG)
   within the CRC/Transregio 205/1 "The Adrenal: Central Relay in Health
   and Disease" and the IRTG2251.
CR AGUILERA G, 1995, J CLIN INVEST, V96, P1512, DOI 10.1172/JCI118189
   Aguilera G, 1996, ENDOCR RES, V22, P433, DOI 10.1080/07435809609043729
   ANDERSEN HB, 1994, CLIN SCI, V87, P69, DOI 10.1042/cs0870069
   Andoniadou CL, 2016, RES PERSPECT END INT, P103, DOI 10.1007/978-3-319-41603-8_8
   Andrew R, 1998, J CLIN ENDOCR METAB, V83, P1806, DOI 10.1210/jc.83.5.1806
   Arnaldi G, 2003, J CLIN ENDOCR METAB, V88, P5593, DOI 10.1210/jc.2003-030871
   Arseneault L, 2017, WORLD PSYCHIATRY, V16, P27, DOI 10.1002/wps.20399
   Attanayake Vindya, 2009, Med Confl Surviv, V25, P4, DOI 10.1080/13623690802568913
   Barzon L, 2003, EUR J ENDOCRINOL, V149, P273, DOI 10.1530/eje.0.1490273
   Berton O, 2006, SCIENCE, V311, P864, DOI 10.1126/science.1120972
   Björkqvist K, 2001, PHYSIOL BEHAV, V73, P435, DOI 10.1016/S0031-9384(01)00490-5
   BLACK VH, 1979, AM J ANAT, V156, P453, DOI 10.1002/aja.1001560404
   Block JP, 2009, AM J EPIDEMIOL, V170, P181, DOI 10.1093/aje/kwp104
   Bornstein SR, 2006, MOL PSYCHIATR, V11, P892, DOI 10.1038/sj.mp.4001873
   Bornstein SR, 2019, MOL PSYCHIATR, V24, P2, DOI 10.1038/s41380-018-0244-9
   Bornstein SR, 2004, MOL CELL ENDOCRINOL, V215, P135, DOI 10.1016/j.mce.2003.11.022
   BORNSTEIN SR, 1990, ENDOCRINOLOGY, V127, P900, DOI 10.1210/endo-127-2-900
   Bornstein SR, 1997, DIABETES, V46, P1235, DOI 10.2337/diabetes.46.7.1235
   Bornstein SR, 2016, J CLIN ENDOCR METAB, V101, P364, DOI 10.1210/jc.2015-1710
   Buettner R, 2007, OBESITY, V15, P798, DOI 10.1038/oby.2007.608
   Campbell JC, 2002, LANCET, V359, P1331, DOI 10.1016/S0140-6736(02)08336-8
   CARBALLEIRA A, 1980, PERSPECT BIOL MED, V23, P573
   Carter JR, 2015, COMPR PHYSIOL, V5, P119, DOI 10.1002/cphy.c140030
   Cheeta S, 1997, BIOL PSYCHIAT, V41, P419, DOI 10.1016/S0006-3223(96)00058-3
   Chung KF, 2011, MOL CELL ENDOCRINOL, V336, P141, DOI 10.1016/j.mce.2010.11.028
   Coker AL, 2002, AM J PREV MED, V23, P260, DOI 10.1016/S0749-3797(02)00514-7
   Cox B, 2017, J ENDOCRINOL, V234, pR135, DOI 10.1530/JOE-17-0083
   CRYER PE, 1993, INT J OBES RELAT S3, V17, pS68
   CRYER PE, 1993, INT J OBES RELAT S3, V17, pS4
   Danese A, 2009, ARCH PEDIAT ADOL MED, V163, P1135, DOI 10.1001/archpediatrics.2009.214
   Davidson RJ, 2012, NAT NEUROSCI, V15, P689, DOI 10.1038/nn.3093
   de Celis MFR, 2015, STEM CELLS, V33, P2037, DOI 10.1002/stem.2002
   DEANE HW, 1947, J CLIN ENDOCR METAB, V7, P457
   Del Rio G, 2000, INT J OBESITY, V24, pS89, DOI 10.1038/sj.ijo.0801287
   DEPERGOLA G, 1991, METABOLISM, V40, P187, DOI 10.1016/0026-0495(91)90172-S
   Depke M, 2008, ENDOCRINOLOGY, V149, P2714, DOI 10.1210/en.2008-0038
   Djamshidian A, 2014, J NEUROL NEUROSUR PS, V85, P879, DOI 10.1136/jnnp-2013-305911
   EGAN BM, 1994, AM J HYPERTENS, V7, P886, DOI 10.1093/ajh/7.10.886
   Ehrhart-Bornstein M, 1998, ENDOCR REV, V19, P101, DOI 10.1210/er.19.2.101
   Ehrhart-Bornstein M, 2003, P NATL ACAD SCI USA, V100, P14211, DOI 10.1073/pnas.2336140100
   Ehrhart-Bornstein M, 2008, ANN NY ACAD SCI, V1148, P112, DOI 10.1196/annals.1410.053
   Engeli S, 2001, J MOL MED, V79, P21, DOI 10.1007/s001090000144
   Esler M, 2006, HYPERTENSION, V48, P787, DOI 10.1161/01.HYP.0000242642.42177.49
   Farooqui M, 2017, TRENDS PSYCHIATR PSY, V39, P135, DOI 10.1590/2237-6089-2016-0029
   Felitti VJ, 1998, AM J PREV MED, V14, P245, DOI 10.1016/S0749-3797(98)00017-8
   Finco I, 2018, ENDOCRINOLOGY, V159, P579, DOI 10.1210/en.2017-03061
   Fraulob JC, 2010, J CLIN BIOCHEM NUTR, V46, P212, DOI 10.3164/jcbn.09-83
   FRIEND DS, 1972, J CELL BIOL, V53, P148, DOI 10.1083/jcb.53.1.148
   Füchsl AM, 2013, STRESS, V16, P461, DOI 10.3109/10253890.2013.793303
   Gabriel R, 2007, EUR PSYCHIAT, V22, P339, DOI 10.1016/j.eurpsy.2006.10.007
   Glasow A, 2000, EUR J CLIN INVEST, V30, P39, DOI 10.1046/j.1365-2362.2000.0300s3039.x
   GLOVER WE, 1962, J PHYSIOL-LONDON, V164, P422, DOI 10.1113/jphysiol.1962.sp007029
   Goldstein DS, 2018, CELL MOL NEUROBIOL, V38, P13, DOI 10.1007/s10571-017-0497-x
   Goodfriend TL, 2004, HYPERTENSION, V43, P518, DOI 10.1161/01.HYP.0000116223.97436.e5
   Goodfriend TL, 2002, PROSTAG LEUKOTR ESS, V67, P163, DOI 10.1054/plef.2002.0414
   Hansen ÅM, 2006, J PSYCHOSOM RES, V60, P63, DOI 10.1016/j.jpsychores.2005.06.078
   Heim C, 2001, BIOL PSYCHIAT, V49, P1023, DOI 10.1016/S0006-3223(01)01157-X
   Herman JP, 2016, COMPR PHYSIOL, V6, P603, DOI 10.1002/cphy.c150015
   HERMAN JP, 1995, NEUROENDOCRINOLOGY, V61, P180, DOI 10.1159/000126839
   Hollis F, 2014, ILAR J, V55, P221, DOI 10.1093/ilar/ilu002
   Keeney A, 2006, J NEUROENDOCRINOL, V18, P330, DOI 10.1111/j.1365-2826.2006.01422.x
   KEENEY DS, 1995, ENDOCRINOLOGY, V136, P4872, DOI 10.1210/en.136.11.4872
   Kinyua AW, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-23298-2
   Koko V, 2004, J EXP BIOL, V207, P4225, DOI 10.1242/jeb.01280
   KVETNANSKY R, 1993, ENDOCRINOLOGY, V133, P1411, DOI 10.1210/en.133.3.1411
   LABRIE F, 1984, J STEROID BIOCHEM, V20, P153, DOI 10.1016/0022-4731(84)90202-4
   Lee ZSK, 2001, METABOLISM, V50, P135, DOI 10.1053/meta.2001.19502
   LICATA G, 1994, AM J HYPERTENS, V7, P314, DOI 10.1093/ajh/7.4.314
   Livingstone DEW, 2005, OBES RES, V13, P1523, DOI 10.1038/oby.2005.186
   Maccario M, 1999, CLIN ENDOCRINOL, V50, P595, DOI 10.1046/j.1365-2265.1999.00692.x
   Manukhina E.B., 2018, J APPL PHYSL
   McInnes KJ, 2004, J BIOL CHEM, V279, P22908, DOI 10.1074/jbc.M402822200
   Merke DP, 2000, NEW ENGL J MED, V343, P1362, DOI 10.1056/NEJM200011093431903
   Merke DP, 2005, LANCET, V365, P2125, DOI 10.1016/S0140-6736(05)66736-0
   Mete F, 2012, INDIAN J MED RES, V135, P233
   Modecki KL, 2014, J ADOLESCENT HEALTH, V55, P602, DOI 10.1016/j.jadohealth.2014.06.007
   Morohashi K, 2011, MOL CELL ENDOCRINOL, V336, P193, DOI 10.1016/j.mce.2010.11.026
   Muscogiuri G, 2011, CLIN ENDOCRINOL, V74, P300, DOI 10.1111/j.1365-2265.2010.03928.x
   NIESCHLAG E, 1973, J ENDOCRINOL, V57, P123, DOI 10.1677/joe.0.0570123
   NUSSDORFER GG, 1980, INT REV CYTOL, V64, P307, DOI 10.1016/S0074-7696(08)60240-5
   Nyuyki KD, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0052371
   Oosthuizen Frasia, 2005, Neuropsychiatr Dis Treat, V1, P109, DOI 10.2147/nedt.1.2.109.61049
   Park YS, 2008, ENDOCRINOLOGY, V149, P4921, DOI 10.1210/en.2007-1798
   Patterson ZR, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00130
   Patz JA, 2005, NATURE, V438, P310, DOI 10.1038/nature04188
   Paust HJ, 2006, EXP CLIN ENDOCR DIAB, V114, P6, DOI 10.1055/s-2005-873007
   Petrov ME, 2016, J BEHAV MED, V39, P716, DOI 10.1007/s10865-016-9742-x
   Petrovic-Kosanovic D, 2012, CENT EUR J BIOL, V7, P611, DOI 10.2478/s11535-012-0055-y
   Pignatti E, 2017, MOL CELL ENDOCRINOL, V441, P146, DOI 10.1016/j.mce.2016.09.003
   PITTS GC, 1977, AM J PHYSIOL, V232, pR38, DOI 10.1152/ajpregu.1977.232.1.R38
   Rabasa C, 2016, CURR OPIN BEHAV SCI, V9, P71, DOI 10.1016/j.cobeha.2016.01.011
   Reber SO, 2007, ENDOCRINOLOGY, V148, P670, DOI 10.1210/en.2006-0983
   Reber SO, 2006, ENDOCRINOLOGY, V147, P4968, DOI 10.1210/en.2006-0347
   Reimann M., 2017, INT J OBES LOND
   Resende LS, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.202
   RHODIN JAG, 1971, J ULTRA MOL STRUCT R, V34, P23, DOI 10.1016/S0022-5320(71)90004-9
   Riley EH, 2010, J EPIDEMIOL COMMUN H, V64, P413, DOI 10.1136/jech.2009.095109
   RODDIE IC, 1977, IRISH J MED SCI, V146, P395, DOI 10.1007/BF03030998
   Rosmond R, 1998, J CLIN ENDOCR METAB, V83, P1853, DOI 10.1210/jc.83.6.1853
   Salehi M, 2005, HORM METAB RES, V37, P193, DOI 10.1055/s-2005-861374
   Sapolsky RM, 2000, ENDOCR REV, V21, P55, DOI 10.1210/er.21.1.55
   Schmidt MV, 2007, PSYCHONEUROENDOCRINO, V32, P417, DOI 10.1016/j.psyneuen.2007.02.011
   SELYE H, 1946, J ALLERGY, V17, P289
   SHELTON JH, 1971, ANAT RECORD, V170, P147, DOI 10.1002/ar.1091700204
   Shonkoff JP, 2009, JAMA-J AM MED ASSOC, V301, P2252, DOI 10.1001/jama.2009.754
   Sicard F, 2007, P NATL ACAD SCI USA, V104, P2007, DOI 10.1073/pnas.0610898104
   Slattery DA, 2012, PSYCHONEUROENDOCRINO, V37, P702, DOI 10.1016/j.psyneuen.2011.09.002
   SOWERS JR, 1982, J CLIN ENDOCR METAB, V54, P1181, DOI 10.1210/jcem-54-6-1181
   Steenblock C, 2018, P NATL ACAD SCI USA, V115, P12997, DOI 10.1073/pnas.1814072115
   Steenblock C, 2017, MOL CELL ENDOCRINOL, V441, P156, DOI 10.1016/j.mce.2016.09.011
   Stewart PM, 1999, LANCET, V353, P1341, DOI 10.1016/S0140-6736(98)06102-9
   Suárez AL, 2012, ACTA DERM-VENEREOL, V92, P7, DOI 10.2340/00015555-1188
   Swierczynska MM, 2015, INT J OBESITY, V39, P321, DOI 10.1038/ijo.2014.102
   TCHERNOF A, 1995, METABOLISM, V44, P513, DOI 10.1016/0026-0495(95)90060-8
   Tost H, 2015, NAT NEUROSCI, V18, P1421, DOI 10.1038/nn.4108
   Ulrich-Lai YM, 2006, AM J PHYSIOL-ENDOC M, V291, pE965, DOI 10.1152/ajpendo.00070.2006
   Uschold-Schmidt N, 2013, J ENDOCRINOL, V218, P193, DOI 10.1530/JOE-13-0027
   Uschold-Schmidt N, 2012, PSYCHONEUROENDOCRINO, V37, P1676, DOI 10.1016/j.psyneuen.2012.02.015
   Varghese Femina P., 2001, Prim Care Companion J Clin Psychiatry, V3, P151
   Vodicka M., 2018, BRAIN BEHAV IMMUN
   Walczak EM, 2015, NAT REV ENDOCRINOL, V11, P14, DOI 10.1038/nrendo.2014.166
   Walczak EM, 2014, MOL ENDOCRINOL, V28, P1471, DOI 10.1210/me.2014-1060
   Wang L, 2015, BIOMED REP, V3, P425, DOI 10.3892/br.2015.445
   WEAVER JU, 1993, CLIN ENDOCRINOL, V39, P345, DOI 10.1111/j.1365-2265.1993.tb02375.x
   Webb SJ, 2006, DRUG METAB REV, V38, P89, DOI 10.1080/03602530600569877
   WILLNER P, 1992, NEUROSCI BIOBEHAV R, V16, P525, DOI 10.1016/S0149-7634(05)80194-0
   Wood SK, 2015, NEUROBIOL STRESS, V1, P164, DOI 10.1016/j.ynstr.2014.11.002
   WURTMAN RJ, 1965, SCIENCE, V150, P1464, DOI 10.1126/science.150.3702.1464
   Yehuda R, 1997, ANN NY ACAD SCI, V821, P57, DOI 10.1111/j.1749-6632.1997.tb48269.x
NR 129
TC 59
Z9 61
U1 1
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0960-0760
J9 J STEROID BIOCHEM
JI J. Steroid Biochem. Mol. Biol.
PD JUN
PY 2019
VL 190
BP 198
EP 206
DI 10.1016/j.jsbmb.2019.04.006
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA IC6MX
UT WOS:000471087300021
PM 30959152
DA 2025-06-11
ER

PT J
AU Iannotti, RJ
   Wang, J
AF Iannotti, Ronald J.
   Wang, Jing
TI Patterns of Physical Activity, Sedentary Behavior, and Diet in U.S.
   Adolescents
SO JOURNAL OF ADOLESCENT HEALTH
LA English
DT Article
DE Adolescent obesity; Physical activity; Sedentary behavior; Diet; Body
   mass index; Television
ID LATENT CLASS ANALYSIS; METABOLIC SYNDROME; HEALTH; OBESITY; CHILDREN;
   DETERMINANTS; ASSOCIATIONS; RELIABILITY; VALIDITY; FAMILY
AB Objective: To identify patterns in adolescents' obesogenic behaviors and their relations to physical and psychological health.
   Methods: A nationally representative sample of 9,174 U. S. adolescents ages 11 to 16 years was surveyed on physical activity (PA), screen-based sedentary behavior (SB), frequency of consumption of healthy and unhealthy food items, weight status, weight control behavior, depression, physical symptoms, body dissatisfaction, overall health, and life satisfaction. Latent class analysis was used to identify patterns of PA, SB, and diet.
   Results: A model with three latent classes best fit the data: Class 1 with high PA and high fruit and vegetable intake and low SB and intake of sweets, soft drinks, chips, and fries; Class 2 with high SB and high intake of sweets, soft drinks, chips, and fries; and Class 3 with low PA, low fruit and vegetable intake, and low intake of sweets, chips, and fries. Membership in the three classes was related to age, gender, race/ethnicity, and socioeconomic status. In addition, members of Class 1 (26.5%) were more likely to be of normal weight status and to fare well on most of the other health indices; of Class 2 (26.4%) were less likely to be trying to lose weight but scored poorly on the mental health indices; and of Class 3 (47.2%) were less likely to be underweight and reported greater body dissatisfaction.
   Conclusions: Three prevalent patterns of adolescent obesogenic behaviors were identified and these patterns related to weight status, depression, and other indicators of physical and psychological health. Published by Elsevier Inc. on behalf of Society for Adolescent Health and Medicine.
C1 [Iannotti, Ronald J.; Wang, Jing] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Prevent Res Branch, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver
   National Institute of Child Health & Human Development (NICHD)
RP Iannotti, RJ (corresponding author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Prevent Res Branch, 6100 Execut Blvd,7B05, Bethesda, MD 20892 USA.
EM iannottr@mail.nih.gov
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development [N01-HD-5-3401]; Maternal and Child Health Bureau of the
   Health Resources and Services Administration
FX This research was supported in part by the intramural research program
   of the Eunice Kennedy Shriver National Institute of Child Health and
   Human Development (Contract N01-HD-5-3401) and by the Maternal and Child
   Health Bureau of the Health Resources and Services Administration with
   the first author (Ronald J. Iannotti) as principal investigator. This
   work was previously reported at the International Society for Behavioral
   Nutrition and Physical Activity.
CR [Anonymous], 2010, DIET GUID AM 2010
   [Anonymous], 1965, PATTERN HUMAN CONCER
   Bar-on ME, 2001, PEDIATRICS, V107, P423, DOI 10.1542/peds.107.2.423
   Boone-Heinonen J, 2010, INT J BEHAV NUTR PHY, V7, DOI 10.1186/1479-5868-7-45
   Carlson JJ, 2011, J AM DIET ASSOC, V111, P1688, DOI 10.1016/j.jada.2011.08.008
   Carver A, 2010, SOC SCI MED, V70, P1799, DOI 10.1016/j.socscimed.2010.02.010
   Currie C., 2008, INEQUALITIES YOUNG P
   Dahlberg L.L., 2005, Measuring violence-related attitudes, behaviors, and influences among youths: A compendium of assessment tools, V2nd
   DeMattia L, 2007, OBES REV, V8, P69, DOI 10.1111/j.1467-789X.2006.00259.x
   Deshmukh-Taskar PR, 2009, PUBLIC HEALTH NUTR, V12, P2493, DOI 10.1017/S1368980009991261
   Edmundson E, 1996, PREV MED, V25, P442, DOI 10.1006/pmed.1996.0076
   Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents, 2011, Pediatrics, V128 Suppl 5, pS213, DOI 10.1542/peds.2009-2107C
   Goodman E, 2000, PEDIATRICS, V106, P52, DOI 10.1542/peds.106.1.52
   Hair EC, 2009, J ADOLESCENT HEALTH, V45, P253, DOI 10.1016/j.jadohealth.2009.02.009
   Hallal PC, 2006, SPORTS MED, V36, P1019, DOI 10.2165/00007256-200636120-00003
   Haugland S, 2001, EUR J PUBLIC HEALTH, V11, P4, DOI 10.1093/eurpub/11.1.4
   Ho SY, 2010, INT J PEDIATR OBES, V5, P420, DOI 10.3109/17477160903505910
   Huh J, 2011, OBESITY, V19, P652, DOI 10.1038/oby.2010.228
   Iannotti RJ, 2009, INT J PUBLIC HEALTH, V54, P191, DOI 10.1007/s00038-009-5410-z
   Iannotti RJ, 2009, J ADOLESCENT HEALTH, V44, P493, DOI 10.1016/j.jadohealth.2008.10.142
   Idler EL, 1997, J HEALTH SOC BEHAV, V38, P21, DOI 10.2307/2955359
   Kuczmarski RJ, 2002, VITAL HLTH STAT
   Liu JH, 2010, J PHYS ACT HEALTH, V7, P465, DOI 10.1123/jpah.7.4.465
   Magidson J., 2002, Can. J. Mark. Res., V20, P36, DOI DOI 10.1037/MET0000095
   Menschik D, 2008, ARCH PEDIAT ADOL MED, V162, P29, DOI 10.1001/archpediatrics.2007.14
   Muthen B. O., 1998, MPLUS USERS GUIDE
   Orbach I, 1998, PSYCHOL ASSESSMENT, V10, P415, DOI 10.1037/1040-3590.10.4.415
   Patnode CD, 2011, J PHYS ACT HEALTH, V8, P457, DOI 10.1123/jpah.8.4.457
   Patrick H, 2005, J AM COLL NUTR, V24, P83, DOI 10.1080/07315724.2005.10719448
   Pietiläinen KH, 2008, OBESITY, V16, P409, DOI 10.1038/oby.2007.72
   Prochaska JJ, 2001, ARCH PEDIAT ADOL MED, V155, P554, DOI 10.1001/archpedi.155.5.554
   Pronk NP, 2004, AM J PREV MED, V27, P25, DOI 10.1016/j.amepre.2004.04.022
   Rangul V, 2008, BMC MED RES METHODOL, V8, DOI 10.1186/1471-2288-8-47
   Roberts C, 2009, Int J Public Health, V54 Suppl 2, P140, DOI 10.1007/s00038-009-5405-9
   Strong WB, 2005, J PEDIATR-US, V146, P732, DOI 10.1016/j.jpeds.2005.01.055
   Ussher MH, 2007, SOC PSYCH PSYCH EPID, V42, P851, DOI 10.1007/s00127-007-0232-x
   Utter J, 2003, J AM DIET ASSOC, V103, P1298, DOI 10.1016/S0002-8223(03)01079-4
   Vereecken CA, 2006, PUBLIC HEALTH NUTR, V9, P244, DOI 10.1079/PHN2005847
   Vereecken CA, 2003, PUBLIC HEALTH NUTR, V6, P581, DOI 10.1079/PHN2003466
   Whitesell NR, 2006, J STUD ALCOHOL, V67, P32, DOI 10.15288/jsa.2006.67.32
NR 40
TC 85
Z9 102
U1 1
U2 72
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1054-139X
EI 1879-1972
J9 J ADOLESCENT HEALTH
JI J. Adolesc. Health
PD AUG
PY 2013
VL 53
IS 2
BP 280
EP 286
DI 10.1016/j.jadohealth.2013.03.007
PG 7
WC Psychology, Developmental; Public, Environmental & Occupational Health;
   Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Public, Environmental & Occupational Health; Pediatrics
GA 186SM
UT WOS:000322065100020
PM 23642973
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kunin-Batson, AS
   Haapala, J
   Crain, AL
   Gunnar, MR
   Kharbanda, EO
   Kelly, AS
   Seburg, EM
   Sherwood, NE
   French, SA
AF Kunin-Batson, Alicia S.
   Haapala, Jacob
   Crain, A. Lauren
   Gunnar, Megan R.
   Kharbanda, Elyse O.
   Kelly, Aaron S.
   Seburg, Elisabeth M.
   Sherwood, Nancy E.
   French, Simone A.
TI Cumulative environmental stress and emerging cardiometabolic risk during
   childhood
SO PEDIATRIC OBESITY
LA English
DT Article
DE childhood; health disparities; obesity; stress
ID CORONARY-HEART-DISEASE; SOCIOECONOMIC POSITION; BLOOD-PRESSURE;
   ADULTHOOD; HEALTH; NEIGHBORHOOD; CHILDREN; LINKING; OBESITY; INCOME
AB Objective: To prospectively evaluate the relationship between cumulative environmental stress and cardiometabolic risk in middle childhood, and to examine whether hair cortisol, a measure of hypothalamic pituitary adrenal-axis activity, mediates this relationship. Methods; In a cohort of children from low-income households (n = 320; 59% Hispanic, 23% Black, body mass index (BMI) percentile >50th at enrollment), environmental stressors including family and neighbourhood factors representing disadvantage/deprivation, and cortisol concentrations from hair samples, were measured over five timepoints beginning when children were 2-4 years old. Cardiometabolic risk factors (i.e., BMI, blood pressure, lipids, blood sugar, C-reactive protein) were measured at the final timepoint when children were 7-11 years of age. Results: In adjusted logistic regression models, greater cumulative environmental stress was associated with a higher likelihood of elevated cardiometabolic risk in middle childhood (p = 0.01). Children from minoritized racial/ethnic groups had a higher prevalence of both stressors and cardiometabolic risk factors. Cumulative environmental stress was associated with higher hair cortisol concentrations (p < 0.01). However, hair cortisol was not directly associated with cardiometabolic risk factors and did not explain the association between environmental stress and cardiometabolic risk in causal mediation analysis. Conclusions: The influence of cumulative stress on cardiometabolic health can be observed in middle childhood and may contribute to cardiometabolic health disparities, highlighting the importance of public health interventions to mitigate disadvantage.
C1 [Kunin-Batson, Alicia S.; Kelly, Aaron S.] Univ Minnesota, Med Sch, Dept Pediat, Minneapolis, MN USA.
   [Kunin-Batson, Alicia S.; Kelly, Aaron S.] Univ Minnesota, Ctr Pediat Obes Med, Med Sch, Minneapolis, MN USA.
   [Haapala, Jacob; Crain, A. Lauren; Kharbanda, Elyse O.; Seburg, Elisabeth M.] HealthPartners Inst, Bloomington, MN USA.
   [Gunnar, Megan R.] Univ Minnesota, Inst Child Dev, Minneapolis, MN USA.
   [Sherwood, Nancy E.; French, Simone A.] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.
   [Kunin-Batson, Alicia S.] Univ Minnesota, Med Sch, Dept Pediat, 717 Delaware St SE, Minneapolis, MN 55414 USA.
   [Kunin-Batson, Alicia S.] Univ Minnesota, Ctr Pediat Obes Med, Med Sch, 717 Delaware St SE, Minneapolis, MN 55414 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities;
   HealthPartners Institute for Education & Research; University of
   Minnesota System; University of Minnesota Twin Cities; University of
   Minnesota System; University of Minnesota Twin Cities; University of
   Minnesota System; University of Minnesota Twin Cities; University of
   Minnesota System; University of Minnesota Twin Cities
RP Kunin-Batson, AS (corresponding author), Univ Minnesota, Med Sch, Dept Pediat, 717 Delaware St SE, Minneapolis, MN 55414 USA.; Kunin-Batson, AS (corresponding author), Univ Minnesota, Ctr Pediat Obes Med, Med Sch, 717 Delaware St SE, Minneapolis, MN 55414 USA.
EM kunin003@umn.edu
RI Kunin-Batson, Alicia/GQY-8621-2022
OI French, Simone/0000-0003-3413-5985; Kharbanda,
   Elyse/0000-0003-1806-6502; Sherwood, Nancy/0000-0002-3365-9018;
   Kunin-Batson, Alicia/0000-0002-7607-5602
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development [R01HD090059, U01HD068990]; Eunice Kennedy Shriver National
   Institute of Child Health and Human Development of the National
   Institutes of Health; Center for Neurobehavioral Development, University
   of Minnesota
FX This work was supported by the Eunice Kennedy Shriver National Institute
   of Child Health and Human Development of the National Institutes of
   Health under award numbers R01HD090059 and U01HD068990, and in part by
   the Center for Neurobehavioral Development, University of Minnesota. The
   content is solely the responsibility of the authors and does not
   necessarily represent the official views of the funders.
CR Acevedo-Garcia D, 2020, HEALTH AFFAIR, V39, P1693, DOI 10.1377/hlthaff.2020.00735
   Acevedo-Garcia D, 2016, HOUS POLICY DEBATE, V26, P607, DOI 10.1080/10511482.2016.1198410
   Baltrus PT, 2007, ANN EPIDEMIOL, V17, P608, DOI 10.1016/j.annepidem.2007.03.007
   BARON RM, 1986, J PERS SOC PSYCHOL, V51, P1173, DOI 10.1037/0022-3514.51.6.1173
   Bennett CM, 2007, DIABETIC MED, V24, P333, DOI 10.1111/j.1464-5491.2007.02106.x
   Bernardo CD, 2017, OBES REV, V18, P1040, DOI 10.1111/obr.12564
   Bickel G., 2000, GUIDE MEASURING HOUS
   da Luz PL, 2008, CLINICS, V63, P427, DOI 10.1590/S1807-59322008000400003
   Danese A, 2012, PHYSIOL BEHAV, V106, P29, DOI 10.1016/j.physbeh.2011.08.019
   Dong MX, 2004, CIRCULATION, V110, P1761, DOI 10.1161/01.CIR.0000143074.54995.7F
   Elsenburg LK, 2017, OBESITY, V25, P820, DOI 10.1002/oby.21797
   EVANS GW, 2013, PSYCHOL BULL, V139, P1342, DOI DOI 10.1037/A0031808
   Fan YL, 2012, SOC SCI MED, V74, P1939, DOI 10.1016/j.socscimed.2012.01.039
   Flynn JT, 2017, PEDIATRICS, V140, DOI [10.1542/peds.2017-3035, 10.1542/peds.2017-1904]
   Foster S, 2008, PREV MED, V47, P241, DOI 10.1016/j.ypmed.2008.03.017
   French Simone A, 2018, Am J Public Health, V108, P1695, DOI 10.2105/AJPH.2018.304696
   Friedman EM, 2015, J AGING HEALTH, V27, P1311, DOI 10.1177/0898264315580122
   Godoy LC, 2021, JAMA CARDIOL, V6, P228, DOI 10.1001/jamacardio.2020.6050
   Soares AG, 2021, J AM HEART ASSOC, V10, DOI 10.1161/JAHA.121.021701
   Goodman E, 2005, PSYCHOSOM MED, V67, P9, DOI 10.1097/01.psy.0000149254.36133.1a
   Gundersen C, 2011, OBES REV, V12, pe54, DOI 10.1111/j.1467-789X.2010.00813.x
   Gunnar MR, 2022, PSYCHONEUROENDOCRINO, V144, DOI 10.1016/j.psyneuen.2022.105892
   Gunstad J, 2006, PSYCHIAT RES, V142, P31, DOI 10.1016/j.psychres.2005.11.007
   HOLMES TH, 1967, J PSYCHOSOM RES, V11, P213, DOI 10.1016/0022-3999(67)90010-4
   Huang RC, 2015, J NUTR SCI, V4, DOI 10.1017/jns.2014.69
   Iob E, 2019, CURR CARDIOL REP, V21, DOI 10.1007/s11886-019-1208-7
   Jacobs DR Jr, 2022, NEW ENGL J MED, V386, P1877, DOI 10.1056/NEJMoa2109191
   Javed Z, 2022, J PUBLIC HEALTH MAN, V28, pS91, DOI 10.1097/PHH.0000000000001441
   Juster RP, 2010, NEUROSCI BIOBEHAV R, V35, P2, DOI 10.1016/j.neubiorev.2009.10.002
   Kirschbaum C, 2009, PSYCHONEUROENDOCRINO, V34, P32, DOI 10.1016/j.psyneuen.2008.08.024
   Kittleson MM, 2006, ARCH INTERN MED, V166, P2356, DOI 10.1001/archinte.166.21.2356
   Lawlor DA, 2002, BRIT MED J, V325, P805, DOI 10.1136/bmj.325.7368.805
   Leal C, 2011, OBES REV, V12, P217, DOI 10.1111/j.1467-789X.2010.00726.x
   Li YW, 2017, ATHEROSCLEROSIS, V259, P75, DOI 10.1016/j.atherosclerosis.2017.02.003
   MACKINNON DP, 1995, MULTIVAR BEHAV RES, V30, P41, DOI 10.1207/s15327906mbr3001_3
   Magge SN, 2017, PEDIATRICS, V140, DOI 10.1542/peds.2017-1603
   Miller G, 2009, ANNU REV PSYCHOL, V60, P501, DOI 10.1146/annurev.psych.60.110707.163551
   Okada T, 2010, CIRC J, V74, P2299, DOI 10.1253/circj.CJ-10-0850
   Okasha M, 2003, J EPIDEMIOL COMMUN H, V57, P508, DOI 10.1136/jech.57.7.508
   Owen CG, 2009, INT J OBESITY, V33, P866, DOI 10.1038/ijo.2009.102
   Qureshi F, 2019, PEDIATRICS, V143, DOI 10.1542/peds.2018-2004
   Ramsay SE, 2007, INT J EPIDEMIOL, V36, P560, DOI 10.1093/ije/dym060
   Ridker PM, 2003, CIRCULATION, V108, pE81, DOI 10.1161/01.CIR.0000093381.57779.67
   Schreier HMC, 2013, PSYCHOL BULL, V139, P606, DOI 10.1037/a0029416
   Senese LC, 2009, EPIDEMIOL REV, V31, P21, DOI 10.1093/epirev/mxp006
   Sherwood NE, 2013, CONTEMP CLIN TRIALS, V36, P544, DOI 10.1016/j.cct.2013.09.015
   Shrewsbury V, 2008, OBESITY, V16, P275, DOI 10.1038/oby.2007.35
   Slopen N, 2015, PSYCHONEUROENDOCRINO, V51, P403, DOI 10.1016/j.psyneuen.2014.10.016
   Slopen N, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0064418
   Smith KE, 2020, J NEURODEV DISORD, V12, DOI 10.1186/s11689-020-09337-y
   Su SY, 2015, CIRCULATION, V131, P1674, DOI 10.1161/CIRCULATIONAHA.114.013104
   Timperio A, 2004, PREV MED, V38, P39, DOI 10.1016/j.ypmed.2003.09.026
   Urbina EM, 2023, HYPERTENSION, V80, P1572, DOI 10.1161/HYPERTENSIONAHA.122.19455
   Urbina EM, 2013, PEDIATRICS, V131, pE1082, DOI 10.1542/peds.2012-1726
   VanderWeele TJ, 2016, ANNU REV PUBL HEALTH, V37, P17, DOI 10.1146/annurev-publhealth-032315-021402
   Vehmeijer FOL, 2021, J CLIN ENDOCR METAB, V106, pE3400, DOI 10.1210/clinem/dgab379
   Zhang W, 2012, SOC SCI MED, V75, P1006, DOI 10.1016/j.socscimed.2012.05.012
NR 57
TC 2
Z9 2
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-6310
EI 2047-6302
J9 PEDIATR OBES
JI Pediatr. Obes.
PD JUN
PY 2024
VL 19
IS 6
DI 10.1111/ijpo.13116
EA MAR 2024
PG 9
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA QM6G9
UT WOS:001193897300001
PM 38549289
OA hybrid
DA 2025-06-11
ER

PT J
AU Haidara, M
   Mikhailidis, DP
   Yassin, HZ
   Dobutovic, B
   Smiljanic, KT
   Soskic, S
   Mousa, SA
   Rizzo, M
   Isenovic, ER
AF Haidara, Mohamed
   Mikhailidis, Dimitri P.
   Yassin, Hanaa Z.
   Dobutovic, Branislava
   Smiljanic, Katarina T.
   Soskic, Sanja
   Mousa, Shaker A.
   Rizzo, Manfredi
   Isenovic, Esma R.
TI Evaluation of the Possible Contribution of Antioxidants Administration
   in Metabolic Syndrome
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE antioxidants; cardiovascular disease; insulin resistance; metabolic
   syndrome; oxidative stress; reactive oxygen species
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; NITRIC-OXIDE SYNTHASE;
   FATTY LIVER-DISEASE; PLASMINOGEN-ACTIVATOR INHIBITOR-1; VITAMIN-E
   SUPPLEMENTATION; INSULIN-RESISTANCE SYNDROME; CHRONIC KIDNEY-DISEASE;
   HUMAN ADIPOSE-TISSUE; ALPHA-LIPOIC ACID
AB The metabolic syndrome (MetS) is common, and its associated risk burdens of diabetes and cardiovascular disease (CVD) are a major public health problem. The hypothesis that main constituent parameters of the MetS share common pathophysiologic mechanisms provides a conceptual framework for the future research. Exercise and weight loss can prevent insulin resistance and reduce the risk of diseases associated with the MetS. Interrupting intracellular and extracellular reactive oxygen species (ROS) overproduction could also contribute to normalizing the activation of metabolic pathways leading to the onset of diabetes, endothelial dysfunction, and cardiovascular (CV) complications. On the other hand, it is difficult to counteract the development of CV complications by using conventional antioxidants. Indeed, interest has focused on strategies that enhance the removal of ROS using either antioxidants or drugs that enhance endogenous antioxidant defense. Although these strategies have been effective in laboratory experiments, several clinical trials have shown that they do not reduce CV events, and in some cases antioxidants have actually worsened the outcome. More research is needed in this field.
C1 [Haidara, Mohamed] Univ Belgrade, Inst Vinca, Lab Radiobiol & Mol Genet, Dept Mol Genet & Radiobiol, Belgrade 11000, Serbia.
   [Haidara, Mohamed; Yassin, Hanaa Z.] Cairo Univ, Kasr Al Aini Fac Med, Dept Physiol, Cairo, Egypt.
   [Mikhailidis, Dimitri P.] UCL, Vasc Dis Prevent Clin, Univ Coll London Med Sch, Dept Clin Biochem, London NW3 2QG, England.
   [Mousa, Shaker A.] Albany Coll Pharm & Hlth Sci, Pharmaceut Res Inst, Rensselaer, NY 12144 USA.
   [Rizzo, Manfredi] Univ Palermo, Dept Internal Med & Med Specialties, I-90133 Palermo, Italy.
C3 University of Belgrade; Egyptian Knowledge Bank (EKB); Cairo University;
   University of London; University College London; Albany College of
   Pharmacy & Health Sciences; University of Palermo
RP Haidara, M (corresponding author), Univ Belgrade, Inst Vinca, Lab Radiobiol & Mol Genet, Dept Mol Genet & Radiobiol, POB 522, Belgrade 11000, Serbia.
EM isenovic@yahoo.com
RI Isenovic, Esma/D-3017-2009; Yassin, Hanaa/AAN-6144-2020; Dobutovic,
   Branislava/A-4976-2010; RIZZO, MANFREDI/GZL-0551-2022; Mikhailidis,
   Dimitri/A-1869-2013; Mousa, Shaker/A-7151-2017; Haidara,
   Mohamed/E-5734-2010; Smiljanic, Katarina/Q-9573-2016
OI Isenovic, Esma/0000-0002-0012-2636; Soskic, Sanja/0000-0002-9482-6940;
   Mousa, Shaker/0000-0002-9294-015X; Haidara, Mohamed/0000-0003-0990-8093;
   RIZZO, Manfredi/0000-0002-9549-8504; Smiljanic,
   Katarina/0000-0003-4774-8895
FU Kasr Al-Aini Research Centre; Ministry of Science, Republic of Serbia
   [173033]
FX This work is part of collaboration between University College of London,
   UK, University of Palermo Italy, the PRI at Albany College of Pharmacy
   and Health Sciences, USA, Cairo University, Egypt and Institute Vinca,
   Serbia and is supported by grants from the Kasr Al-Aini Research Centre
   and the grant No. 173033 (to E.R.I) from the Ministry of Science,
   Republic of Serbia.
CR Abbasi F, 2002, J AM COLL CARDIOL, V40, P937, DOI 10.1016/S0735-1097(02)02051-X
   Abbasi F, 2000, AM J CARDIOL, V85, P45, DOI 10.1016/S0002-9149(99)00604-9
   Adams LA, 2005, DIABETIC MED, V22, P1129, DOI 10.1111/j.1464-5491.2005.01748.x
   Alessi MC, 1997, DIABETES, V46, P860, DOI 10.2337/diabetes.46.5.860
   Alvarez GE, 2002, CIRCULATION, V106, P2533, DOI 10.1161/01.CIR.0000041244.79165.25
   [Anonymous], J HEPATOLOGY
   [Anonymous], AM J HYPERTENS
   [Anonymous], PROG MED RES
   Ansari G, 2008, ADV THER, V25, P681, DOI 10.1007/s12325-008-0075-1
   Athyros VG, 2010, LANCET, V376, P1916, DOI 10.1016/S0140-6736(10)61272-X
   Athyros VG, 2009, CURR PHARM DESIGN, V15, P479, DOI 10.2174/138161209787315729
   Athyros VG, 2004, CURR MED RES OPIN, V20, P1691, DOI 10.1185/030079904X5599
   Baber U, 2007, AM HEART J, V153, P471, DOI 10.1016/j.ahj.2006.10.042
   Balk EM, 2003, ANN INTERN MED, V139, P670, DOI 10.7326/0003-4819-139-8-200310210-00011
   BARRADAS M R, 1987, Diabetes Research and Clinical Practice, V3, P9, DOI 10.1016/S0168-8227(87)80003-7
   Barry OP, 1999, THROMB HAEMOSTASIS, V82, P794, DOI 10.1055/s-0037-1615913
   Bartlett HE, 2008, OPHTHAL PHYSL OPT, V28, P503, DOI 10.1111/j.1475-1313.2008.00595.x
   BAYNES JW, 1991, DIABETES, V40, P405, DOI 10.2337/diabetes.40.4.405
   Bayorh MA, 2004, AM J HYPERTENS, V17, P31, DOI 10.1016/j.amjhyper.2003.08.003
   Becker BN, 1997, J AM SOC NEPHROL, V8, P475
   Belfort R, 2010, J CLIN ENDOCR METAB, V95, P829, DOI 10.1210/jc.2009-1487
   Berg AH, 2004, AM J PHYSIOL-ENDOC M, V287, pE1178, DOI 10.1152/ajpendo.00002.2004
   Bjelakovic G, 2007, JAMA-J AM MED ASSOC, V297, P842, DOI 10.1001/jama.297.8.842
   Bochud M, 2006, HYPERTENSION, V48, P239, DOI 10.1161/01.HYP.0000231338.41548.fc
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Byrne CD, 2009, CLIN SCI, V116, P539, DOI 10.1042/CS20080253
   Cachofeiro V, 2008, KIDNEY INT, V74, pS4, DOI 10.1038/ki.2008.516
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Charles MA, 1998, DIABETES CARE, V21, P1967, DOI 10.2337/diacare.21.11.1967
   Chen H, 2006, AM J PHYSIOL-HEART C, V290, pH137, DOI 10.1152/ajpheart.00768.2005
   Cherubini A, 2005, FREE RADICAL BIO MED, V39, P841, DOI 10.1016/j.freeradbiomed.2005.06.025
   Chew GT, 2004, QJM-INT J MED, V97, P537, DOI 10.1093/qjmed/hch089
   Chitturi S, 2002, HEPATOLOGY, V35, P373, DOI 10.1053/jhep.2002.30692
   Cigolini M, 1999, ATHEROSCLEROSIS, V143, P81, DOI 10.1016/S0021-9150(98)00281-0
   Coliussi G, 2007, DIABETES CARE, V30, P2349, DOI 10.2337/dc07-0525
   Combs TP, 2004, ENDOCRINOLOGY, V145, P367, DOI 10.1210/en.2003-1068
   Comparcola D, 2010, CLIN GASTROENTEROL H, V8, P97, DOI 10.1016/j.cgh.2009.09.005
   Correia S, 2008, MED CHEM, V4, P358, DOI 10.2174/157340608784872299
   Cosentino F, 1997, CIRCULATION, V96, P25
   CUMMINGS MH, 1995, DIABETES, V44, P1059, DOI 10.2337/diabetes.44.9.1059
   Czernichow S, 2009, AM J CLIN NUTR, V90, P329, DOI 10.3945/ajcn.2009.27635
   Davì G, 2010, CARDIOVASC THER, V28, P216, DOI 10.1111/j.1755-5922.2010.00179.x
   de la Puebla RAF, 2003, NUTR METAB CARDIOVAS, V13, P273, DOI 10.1016/S0939-4753(03)80031-5
   de la Sierra A, 2010, J HUM HYPERTENS, V24, P373, DOI 10.1038/jhh.2009.91
   Desideri G, 2008, MEDIAT INFLAMM, V2008, DOI 10.1155/2008/305087
   Devaraj S, 2004, ENDOCRIN METAB CLIN, V33, P431, DOI 10.1016/j.ecl.2004.03.008
   Diehl Anna Mae, 2004, Clin Liver Dis, V8, P619, DOI 10.1016/j.cld.2004.04.012
   DITSCHUNEIT HH, 1995, OBES RES, V3, P43, DOI 10.1002/j.1550-8528.1995.tb00119.x
   Dounousi E, 2006, AM J KIDNEY DIS, V48, P752, DOI 10.1053/j.ajkd.2006.08.015
   Doupis John, 2007, Rural Remote Health, V7, P744
   Du XL, 2001, J CLIN INVEST, V108, P1341, DOI 10.1172/JCI200111235
   Dufour JF, 2006, CLIN GASTROENTEROL H, V4, P1537, DOI 10.1016/j.cgh.2006.09.025
   Dzau VJ, 2001, HYPERTENSION, V37, P1047, DOI 10.1161/01.HYP.37.4.1047
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   English PJ, 2003, OBES RES, V11, P839, DOI 10.1038/oby.2003.115
   Farvid MS, 2005, DIABETES CARE, V28, P2458, DOI 10.2337/diacare.28.10.2458
   Fasshauer M, 2004, BIOCHIMIE, V86, P779, DOI 10.1016/j.biochi.2004.09.016
   Fedor D, 2009, CURR OPIN CLIN NUTR, V12, P138, DOI 10.1097/MCO.0b013e3283218299
   Fenster BE, 2003, AM HEART J, V146, P218, DOI 10.1016/S0002-8703(02)94796-4
   Fitó M, 2005, ATHEROSCLEROSIS, V181, P149, DOI 10.1016/j.atherosclerosis.2004.12.036
   Florentin M, 2008, CURR OPIN CARDIOL, V23, P370, DOI 10.1097/HCO.0b013e3283043806
   Ford ES, 2008, DIABETES CARE, V31, P587, DOI 10.2337/dc07-1030
   Franzini L, 2008, CURR OPIN CLIN NUTR, V11, P471, DOI 10.1097/MCO.0b013e328303be79
   Fujita M, 2007, HYPERTENSION, V50, P360, DOI 10.1161/HYPERTENSIONAHA.107.091009
   Fujita T, 2006, J RENIN-ANGIO-ALDO S, V7, P181, DOI 10.3317/jraas.2006.029
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gazi I, 2006, METABOLISM, V55, P885, DOI 10.1016/j.metabol.2006.02.015
   Gazi IF, 2007, EXPERT OPIN BIOL TH, V7, P53, DOI 10.1517/14712598.7.1.53
   Gentile M, 2008, CLIN CHIM ACTA, V388, P179, DOI 10.1016/j.cca.2007.10.033
   Giesen PLA, 1999, P NATL ACAD SCI USA, V96, P2311, DOI 10.1073/pnas.96.5.2311
   Ginsberg HN, 2000, J CLIN INVEST, V106, P453, DOI 10.1172/JCI10762
   Ginsberg HN, 2000, J CARDIOVASC RISK, V7, P325
   Ginsberg HN, 2003, AM J CARDIOL, V91, p29E, DOI 10.1016/S0002-9149(02)03386-6
   Ginsberg HN, 2001, AM J CARDIOL, V88, p9H, DOI 10.1016/S0002-9149(01)01831-8
   GISINGER C, 1988, DIABETES, V37, P1260, DOI 10.2337/diabetes.37.9.1260
   Giugliano D, 1996, DIABETES CARE, V19, P257, DOI 10.2337/diacare.19.3.257
   Grattagliano I, 2008, EUR J CLIN INVEST, V38, P523, DOI 10.1111/j.1365-2362.2008.01963.x
   Grattagliano I, 2008, J NUTR BIOCHEM, V19, P491, DOI 10.1016/j.jnutbio.2007.06.011
   Griffin JL, 2006, PHARMACOGENOMICS, V7, P1095, DOI 10.2217/14622416.7.7.1095
   Groop LC, 1999, DIABETES OBES METAB, V1, pS1, DOI 10.1046/j.1463-1326.1999.0010s1001.x
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Guzik TJ, 2000, CIRC RES, V86, pE85, DOI 10.1161/01.RES.86.9.e85
   Haidara M, 2004, MED SCI MONITOR, V10, pBR41
   Haidara MA, 2010, CURR VASC PHARMACOL, V8, P661
   Haidara MA, 2009, J DIABETES COMPLICAT, V23, P130, DOI 10.1016/j.jdiacomp.2008.02.011
   Harrison SA, 2003, AM J GASTROENTEROL, V98, P2485, DOI 10.1111/j.1572-0241.2003.08699.x
   Hartweg J, 2007, DIABETOLOGIA, V50, P1593, DOI 10.1007/s00125-007-0695-z
   Hartweg J, 2007, DIABETOLOGIA, V50, P250, DOI 10.1007/s00125-006-0486-y
   He FJ, 2006, LANCET, V367, P320, DOI 10.1016/S0140-6736(06)68069-0
   Holvoet P, 2008, FUTURE LIPIDOL, V3, P637, DOI 10.2217/17460875.3.6.637
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   JACKSON P, 1995, CLIN CHEM, V41, P1135
   James OFW, 1998, J HEPATOL, V29, P495, DOI 10.1016/S0168-8278(98)80073-1
   JEREMY JY, 1983, DIABETES, V32, P217, DOI 10.2337/diabetes.32.3.217
   JIALAL I, 1992, J LIPID RES, V33, P899
   Johnson RJ, 2005, J AM SOC NEPHROL, V16, P1909, DOI 10.1681/ASN.2005010063
   Julius U, 2007, INT J CLIN PRACT, V61, P1798, DOI 10.1111/j.1742-1241.2007.01507.x
   Kakafika Anna I., 2006, Current Vascular Pharmacology, V4, P175, DOI 10.2174/157016106777698432
   Kalantar-Zadeh K, 2006, AM J KIDNEY DIS, V48, P59, DOI 10.1053/j.ajkd.2006.03.047
   Kaminsky Y, 2010, J CLIN PHARMACOL, V50, P180, DOI 10.1177/0091270009344854
   Kao MPC, 2010, J HUM HYPERTENS, V24, P1, DOI 10.1038/jhh.2009.70
   Kaput J, 2007, CLIN CHEM LAB MED, V45, P279, DOI 10.1515/CCLM.2007.057
   Kaput J, 2007, NUTR METAB CARDIOVAS, V17, P89, DOI 10.1016/j.numecd.2006.11.006
   Kassan M, 2010, EUR J PHARMACOL, V630, P107, DOI 10.1016/j.ejphar.2009.12.037
   Kawano H, 1999, J AM COLL CARDIOL, V34, P146, DOI 10.1016/S0735-1097(99)00168-0
   Kendall DM, 2003, CORONARY ARTERY DIS, V14, P335, DOI 10.1097/01.mca.0000076512.29238.2a
   Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2548, DOI 10.1210/jc.2004-0395
   Kidambi S, 2007, HYPERTENSION, V49, P704, DOI 10.1161/01.HYP.0000253258.36141.c7
   Kolovou GD, 2005, POSTGRAD MED J, V81, P358, DOI 10.1136/pgmj.2004.025601
   Kolovou GD, 2003, J AM COLL NUTR, V22, P80, DOI 10.1080/07315724.2003.10719279
   Kolovou GD, 2011, CURR VASC PHARMACOL, V9, P258
   Kolovou GD, 2011, CURR VASC PHARMACOL, V9, P292
   Koo JR, 2002, CLIN EXP HYPERTENS, V24, P333, DOI 10.1081/CEH-120004795
   Kutuk O, 2003, TRENDS MOL MED, V9, P549, DOI 10.1016/j.molmed.2003.10.007
   Kylin E., 1923, Zentralbl Inn Med, V44, P105
   LANDIN K, 1990, METABOLISM, V39, P1044, DOI 10.1016/0026-0495(90)90164-8
   Landmesser U, 2003, J CLIN INVEST, V111, P1201, DOI 10.1172/JCI200314172
   Lau FC, 2008, MOL CELL BIOCHEM, V317, P1, DOI 10.1007/s11010-008-9744-2
   Lavine JE, 2000, J PEDIATR-US, V136, P734, DOI 10.1016/S0022-3476(00)05040-X
   Li XN, 1997, ARTERIOSCL THROM VAS, V17, P3215, DOI 10.1161/01.ATV.17.11.3215
   Lin CP, 2003, INT J CARDIOL, V89, P53, DOI 10.1016/S0167-5273(02)00428-X
   Lindley TE, 2004, CIRC RES, V94, P402, DOI 10.1161/01.RES.0000112964.40701.93
   Lindsay RS, 2002, LANCET, V360, P57, DOI 10.1016/S0140-6736(02)09335-2
   Locatelli F, 2003, NEPHROL DIAL TRANSPL, V18, P1272, DOI 10.1093/ndt/gfg074
   Mackman N, 2004, ARTERIOSCL THROM VAS, V24, P1015, DOI 10.1161/01.ATV.0000130465.23430.74
   Mak RH, 2006, ADV CHRONIC KIDNEY D, V13, P374, DOI 10.1053/j.ackd.2006.07.003
   Manousou P, 2011, LIVER INT, V31, P730, DOI 10.1111/j.1478-3231.2011.02488.x
   Marchesini G, 1999, AM J MED, V107, P450, DOI 10.1016/S0002-9343(99)00271-5
   Matsui H, 2006, HYPERTENSION, V48, P225, DOI 10.1161/01.HYP.0000232617.48372.cb
   MAZZONE T, 1984, DIABETES, V33, P333, DOI 10.2337/diabetes.33.4.333
   McCarty MF, 2005, MED HYPOTHESES, V64, P151, DOI 10.1016/j.mehy.2004.03.036
   McCullough Arthur J, 2004, Clin Liver Dis, V8, P521, DOI 10.1016/j.cld.2004.04.004
   McFarlane SI, 2001, J CLIN ENDOCR METAB, V86, P713, DOI 10.1210/jc.86.2.713
   Meigs JB, 2000, JAMA-J AM MED ASSOC, V283, P221, DOI 10.1001/jama.283.2.221
   Merabet E, 1997, J CLIN ENDOCR METAB, V82, P847, DOI 10.1210/jc.82.3.847
   Mertens I, 2002, Obes Rev, V3, P85, DOI 10.1046/j.1467-789X.2002.00056.x
   Mihas C, 2011, CURR VASC PHARMACOL, V9, P271, DOI 10.2174/157016111795495530
   Mikhailidis DP, 2011, CURR VASC PHARMACOL, V9, P531
   Mikhailidis DP, 2011, CURR VASC PHARMACOL, V9, P533
   MIKHAILIDIS DP, 1983, METABOLISM, V32, P717, DOI 10.1016/0026-0495(83)90130-0
   Milan G, 2002, OBES RES, V10, P1095, DOI 10.1038/oby.2002.149
   Miller George J., 1995, Current Opinion in Lipidology, V6, P38, DOI 10.1097/00041433-199502000-00009
   Morange PE, 2001, THROMB HAEMOSTASIS, V85, P999, DOI 10.1055/s-0037-1615954
   Moreau KL, 2005, HYPERTENSION, V45, P1107, DOI 10.1161/01.HYP.0000165678.63373.8c
   MRTENSSON J, 1991, P NATL ACAD SCI USA, V88, P4656, DOI 10.1073/pnas.88.11.4656
   MUSSONI L, 1992, ARTERIOSCLER THROMB, V12, P19, DOI 10.1161/01.ATV.12.1.19
   Nagila A, 2009, PHARMACOL REP, V61, P892, DOI 10.1016/S1734-1140(09)70146-X
   Nanayakkara PWB, 2010, NETH J MED, V68, P5
   Ness AR, 1997, INT J EPIDEMIOL, V26, P1, DOI 10.1093/ije/26.1.1
   Ogihara T, 2002, HYPERTENSION, V40, P83, DOI 10.1161/01.HYP.0000022880.45113.C9
   Palomo I, 2006, INT J MOL MED, V18, P969
   Palomo Ivan, 2010, Front Biosci (Schol Ed), V2, P194
   Paraskevas KI, 2008, CURR VASC PHARMACOL, V6, P237, DOI 10.2174/157016108785909724
   Paraskevas KI, 2008, ANGIOLOGY, V59, P397, DOI 10.1177/0003319708318383
   Paraskevas KI, 2006, CURR DRUG TARGETS, V7, P761, DOI 10.2174/138945006777435371
   Patrignani P, 2000, CIRCULATION, V102, P539, DOI 10.1161/01.CIR.102.5.539
   PEUCHANT E, 1994, FREE RADICAL BIO MED, V16, P339, DOI 10.1016/0891-5849(94)90035-3
   Pinzani M, 1998, LIVER, V18, P2
   Pirro M, 2002, ATHEROSCLEROSIS, V160, P377, DOI 10.1016/S0021-9150(01)00588-3
   Portincasa P, 2005, CLIN BIOCHEM, V38, P203, DOI 10.1016/j.clinbiochem.2004.10.014
   Portincasa P, 2006, CLIN SCI, V111, P135, DOI 10.1042/CS20050346
   Raimundo M, 2011, CARDIOL RES PRACT, V2011, DOI 10.4061/2011/747861
   Raszeja-Wyszomirska Joanna, 2008, Pol Merkur Lekarski, V24, P568
   Ray R, 2005, CLIN SCI, V109, P217, DOI 10.1042/CS20050067
   Reaven GM, 1996, NEW ENGL J MED, V334, P374, DOI 10.1056/NEJM199602083340607
   REAVEN GM, 1988, DIABETES METAB REV, V4, P639, DOI 10.1002/dmr.5610040703
   Rebrin I, 2003, FREE RADICAL BIO MED, V35, P626, DOI 10.1016/S0891-5849(03)00388-5
   Reisin E, 2005, AM J MED SCI, V330, P269, DOI 10.1097/00000441-200512000-00003
   Ridker PM, 2005, NEW ENGL J MED, V352, P20, DOI 10.1056/NEJMoa042378
   Rizzo M, 2007, DIABETES-METAB RES, V23, P14, DOI 10.1002/dmrr.694
   Rizzo M, 2009, CLIN ENDOCRINOL, V70, P870, DOI 10.1111/j.1365-2265.2008.03407.x
   Rizzo M, 2009, TRANSL RES, V153, P217, DOI 10.1016/j.trsl.2009.01.008
   Rizzo M, 2009, ACTA DIABETOL, V46, P1, DOI 10.1007/s00592-008-0057-4
   Roberts LJ, 2007, FREE RADICAL BIO MED, V43, P1388, DOI 10.1016/j.freeradbiomed.2007.06.019
   ROCCHINI AP, 1989, NEW ENGL J MED, V321, P580, DOI 10.1056/NEJM198908313210905
   Rueckschloss U, 2001, CIRCULATION, V104, P1767, DOI 10.1161/hc4001.097056
   Sáez GT, 2004, AM J HYPERTENS, V17, P809, DOI 10.1016/j.amjhyper.2004.05.022
   Sajadi S, 2003, DRUG NEWS PERSPECT, V16, P363, DOI 10.1358/dnp.2003.16.6.829308
   Sanyal AJ, 2003, AM J GASTROENTEROL, V98, P2064, DOI [10.1016/S0002-9270(03)00551-3, 10.1111/j.1572-0241.2003.07640.x]
   Sanyal AJ, 2011, HEPATOL RES, V41, P670, DOI 10.1111/j.1872-034X.2011.00824.x
   Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929
   Sautin YY, 2007, AM J PHYSIOL-CELL PH, V293, pC584, DOI 10.1152/ajpcell.00600.2006
   Schiffrin EL, 2007, CIRCULATION, V116, P85, DOI 10.1161/CIRCULATIONAHA.106.678342
   Seddon M, 2007, HEART, V93, P903, DOI 10.1136/hrt.2005.068270
   Seet RCS, 2010, DIABETES CARE, V33, P1140, DOI 10.2337/dc09-2124
   Shukla N, 2004, METABOLISM, V53, P1315, DOI 10.1016/j.metabol.2004.05.007
   Singh U, 2008, NUTR REV, V66, P646, DOI 10.1111/j.1753-4887.2008.00118.x
   Sourris KC, 2009, AM J NEPHROL, V30, P323, DOI 10.1159/000226586
   Steinberg HO, 2002, DIABETOLOGIA, V45, P623, DOI 10.1007/s00125-002-0800-2
   Stocker R, 2004, PHYSIOL REV, V84, P1381, DOI 10.1152/physrev.00047.2003
   Stühlinger MC, 2001, CIRCULATION, V104, P2569, DOI 10.1161/hc4601.098514
   SUTHANTHIRAN M, 1990, P NATL ACAD SCI USA, V87, P3343, DOI 10.1073/pnas.87.9.3343
   Targher G, 2007, DIABETIC MED, V24, P1, DOI 10.1111/j.1464-5491.2007.02025.x
   Tepel M, 2000, KIDNEY INT, V58, P867, DOI 10.1046/j.1523-1755.2000.00236.x
   Terawaki H, 2004, KIDNEY INT, V66, P1988, DOI 10.1111/j.1523-1755.2004.00969.x
   Tribble DL, 2001, AM J MED, V110, P103, DOI 10.1016/S0002-9343(00)00700-2
   Trichopoulos D, 2001, BRIT J NUTR, V85, P133, DOI 10.1079/BJN2000282
   Tsimihodimos V, 2004, J CARDIOVASC PHARM T, V9, P27, DOI 10.1177/107424840400900i105
   Tziomalos K, 2009, CURR PHARM DESIGN, V15, P1054, DOI 10.2174/138161209787846946
   Uzu T, 2006, J HYPERTENS, V24, P1627, DOI 10.1097/01.hjh.0000239299.71001.77
   VAGUE J, 1947, PRESSE MED, V55, P339
   Vekic J, 2007, EUR J CLIN INVEST, V37, P715, DOI 10.1111/j.1365-2362.2007.01849.x
   Vekic J, 2009, ATHEROSCLEROSIS, V203, P236, DOI 10.1016/j.atherosclerosis.2008.05.047
   Velazquez EM, 1997, METABOLISM, V46, P454, DOI 10.1016/S0026-0495(97)90066-4
   VENDEMIALE G, 1995, HEPATOLOGY, V21, P1450, DOI 10.1016/0270-9139(95)90069-1
   Viganò M, 2000, GASTROENTEROLOGY, V118, P986, DOI 10.1016/S0016-5085(00)70193-4
   Vivekananthan DP, 2003, LANCET, V361, P2017, DOI 10.1016/S0140-6736(03)13637-9
   Warnholtz A, 1999, CIRCULATION, V99, P2027, DOI 10.1161/01.CIR.99.15.2027
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Weyer C, 2002, ATHEROSCLEROSIS, V161, P233, DOI 10.1016/S0021-9150(01)00626-8
   Wilcox CS, 2005, AM J PHYSIOL-REG I, V289, pR913, DOI 10.1152/ajpregu.00250.2005
   Witko-Sarsat V, 1998, J IMMUNOL, V161, P2524
   Yamauchi T, 2001, NAT MED, V7, P941, DOI 10.1038/90984
   Yang WS, 2001, J CLIN ENDOCR METAB, V86, P3815, DOI 10.1210/jc.86.8.3815
   Yudkin JS, 1999, DIABETES CARE, V22, pC25
   Zalba G, 2006, NEPHROL DIAL TRANSPL, V21, P2686, DOI 10.1093/ndt/gfl398
   Zhang XC, 2005, EXP NEUROL, V191, P318, DOI 10.1016/j.expneurol.2004.10.011
   Ziegler D, 1999, EXP CLIN ENDOCR DIAB, V107, P421, DOI 10.1055/s-0029-1212132
   Zimmet P, 2001, NATURE, V414, P782, DOI 10.1038/414782a
NR 219
TC 19
Z9 21
U1 0
U2 5
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD NOV
PY 2011
VL 17
IS 33
BP 3699
EP 3712
DI 10.2174/138161211798220882
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 883MJ
UT WOS:000299638000010
PM 22074439
DA 2025-06-11
ER

PT J
AU Matsha, TE
   Macharia, M
   Yako, YY
   Erasmus, RT
   Hassan, MS
   Kengne, AP
AF Matsha, Tandi Edith
   Macharia, Muiruri
   Yako, Yandiswa Yolanda
   Erasmus, Rajiv Timothy
   Hassan, Mogamat Shafick
   Kengne, Andre Pascal
TI Gamma-glutamyltransferase, insulin resistance and cardiometabolic risk
   profile in a middle-aged African population
SO EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
LA English
DT Article
DE Gamma-glutamyltransferase; insulin resistance; metabolic syndrome;
   cardiovascular risk; South Africa
ID METABOLIC SYNDROME; ALANINE AMINOTRANSFERASE; CARDIOVASCULAR-DISEASE;
   COLORED POPULATION; DIABETES-MELLITUS; OXIDATIVE STRESS; LIVER-ENZYMES;
   JAPANESE MEN; FOLLOW-UP; TRANSPEPTIDASE
AB Background Mechanisms linking liver functions with cardiometabolic risk may involve insulin resistance (IR) and non-alcoholic fatty liver disease. We assessed the associations of gamma-glutamyltransferase (GGT) levels with IR and metabolic syndrome (MetS) in an adult South African urban cohort.
   Methods 1198 participants aged >15 years (297 men) were drawn from the Bellville-South suburb (Cape Town). The homeostatic model assessment of insulin (HOMA-IR), -cells function (HOMA-B%), fasting insulin resistance index (FIRI) and the quantitative insulin-sensitivity check index (QUICKI) were calculated, and MetS defined according to the Join Interim Statement 2009 criteria. Associations of GGT levels with covariates were assessed on a continuous scale and across sex-specific quarters of GGT, with adjustment for confounders via generalized linear and logistic regressions.
   Results Indicators of IR (HOMA-IR, FIRI and fasting insulin) increased, whereas those for insulin sensitivity (Sib and QUICKI) diminished significantly linearly and across increasing GGT quarters. In multivariable-adjusted models, adjustment for sex, age, BMI, cigarette smoking and alcohol intake yielded the strongest, significant associations between GGT and all markers of IR/IS and glycemia excluding glucose insulin ratio. In a similar level of adjustments, with/without further adjustment for markers of IR/insulin sensitivity, the prevalence of MetS significantly increased across quarters of GGT.
   Conclusions GGT levels were independently associated with insulin sensitivity and MetS in this population. Unaccounted, chronic elevation of GGT may therefore be a cue to screen and monitor individuals for MetS and diabetes, and may warrant consideration as an indicator of high risk for the development of these metabolic disorders.
C1 [Matsha, Tandi Edith; Yako, Yandiswa Yolanda; Hassan, Mogamat Shafick] Cape Peninsula Univ Technol, Dept Biomed Technol, Cape Town, South Africa.
   [Macharia, Muiruri; Erasmus, Rajiv Timothy] Univ Stellenbosch, Div Chem Pathol, ZA-7600 Stellenbosch, South Africa.
   [Kengne, Andre Pascal] South African Med Res Council, NCRP Cardiovasc & Metab Dis, ZA-7505 Cape Town, South Africa.
   [Kengne, Andre Pascal] Univ Cape Town, ZA-7700 Rondebosch, South Africa.
C3 Cape Peninsula University of Technology; Stellenbosch University; South
   African Medical Research Council; University of Cape Town
RP Kengne, AP (corresponding author), South African Med Res Council, POB 19070 Tygerberg, ZA-7505 Cape Town, South Africa.
EM andre.kengne@mrc.ac.za
RI Kengne, Andre/ABB-3696-2020
OI Matsha, Tandi/0000-0001-5251-030X; Kengne, Andre
   Pascal/0000-0002-5183-131X; Macharia, Muiruri/0000-0002-5508-274X
FU University Research Fund of the Cape Peninsula University of Technology,
   South Africa
FX Data collection for the investigations leading to this manuscript was
   supported by a grant from the University Research Fund of the Cape
   Peninsula University of Technology, South Africa. The above-mentioned
   funding sources played no role in this publication besides funding the
   project.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   ANDERSON ME, 1982, P NATL ACAD SCI-BIOL, V79, P1088, DOI 10.1073/pnas.79.4.1088
   [Anonymous], 1999, Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications: Report of a WHO Consultation-Part 1: Diagnosis and Classification of Diabetes Mellitus
   Bonnet F, 2011, DIABETES, V60, P1660, DOI 10.2337/db10-1806
   Bradshaw D., 1995, CHRONIC DIS LIFESTYL, P5
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Chalmers J, 1999, CLIN EXP HYPERTENS, V21, P1009
   Clark JM, 2003, AM J GASTROENTEROL, V98, P960, DOI [10.1016/S0002-9270(03)00265-X, 10.1111/j.1572-0241.2003.07486.x]
   de Wit E, 2010, HUM GENET, V128, P145, DOI 10.1007/s00439-010-0836-1
   den Boer M, 2004, ARTERIOSCL THROM VAS, V24, P644, DOI 10.1161/01.ATV.0000116217.57583.6e
   EASTON DF, 1991, STAT MED, V10, P1025, DOI 10.1002/sim.4780100703
   Ekstedt M, 2006, HEPATOLOGY, V44, P865, DOI 10.1002/hep.21327
   Erasmus RT, 2012, SAMJ S AFR MED J, V102, P841, DOI [10.7196/SAMJ.5670, 10.7196/samj.5670]
   EWING JA, 1984, JAMA-J AM MED ASSOC, V252, P1905, DOI 10.1001/jama.252.14.1905
   Haghighi S, 2011, J RES MED SCI, V16, P123
   Kaushik Girdhar Gopal, 2009, J Assoc Physicians India, V57, P695
   Kengne AP, 2012, J HEPATOL, V57, P1083, DOI 10.1016/j.jhep.2012.06.034
   Kim CH, 2009, DIABETES-METAB RES, V25, P64, DOI 10.1002/dmrr.890
   Koike T, 2010, OBES RES CLIN PRACT, V4, pE73, DOI 10.1016/j.orcp.2009.09.003
   Kondo T, 2011, EUR J CARDIOV PREV R, V18, P574, DOI 10.1177/1741826710389529
   Lee DH, 2004, J CLIN ENDOCR METAB, V89, P5410, DOI 10.1210/jc.2004-0505
   Lee DH, 2004, FREE RADICAL RES, V38, P535, DOI 10.1080/10715760410001694026
   Lee DH, 2003, CLIN CHEM, V49, P1358, DOI 10.1373/49.8.1358
   Marchesini G, 2005, J ENDOCRINOL INVEST, V28, P333, DOI 10.1007/BF03347199
   Matsha TE, 2012, CARDIOVASC J AFR, V23, P5, DOI 10.5830/CVJA-2010-087
   Monzillo LU, 2003, NUTR REV, V61, P397, DOI 10.1301/nr.2003.dec.397-412
   Onat A, 2012, OBESITY, V20, P842, DOI 10.1038/oby.2011.136
   Shin JY, 2009, DIABETES RES CLIN PR, V84, P152, DOI 10.1016/j.diabres.2009.02.004
   Suh BS, 2012, KOREAN J FAM MED, V33, P51, DOI 10.4082/kjfm.2012.33.1.51
   Whitfield JB, 2001, CRIT REV CL LAB SCI, V38, P263, DOI 10.1080/20014091084227
   Xu Y, 2011, J DIABETES, V3, P38, DOI 10.1111/j.1753-0407.2010.00111.x
   Zemlin AE, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0022558
   Zhang HQ, 2009, AM J RESP CELL MOL, V41, P509, DOI 10.1165/rcmb.2009-0169TR
   Zhang HQ, 2005, METHOD ENZYMOL, V401, P468, DOI 10.1016/S0076-6879(05)01028-1
NR 34
TC 13
Z9 13
U1 0
U2 6
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 2047-4873
EI 2047-4881
J9 EUR J PREV CARDIOL
JI Eur. J. Prev. Cardiol.
PD DEC
PY 2014
VL 21
IS 12
BP 1541
EP 1548
DI 10.1177/2047487313501967
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AT9CF
UT WOS:000345224900011
PM 23945039
OA Bronze
DA 2025-06-11
ER

PT J
AU Devlin, AM
   Panagiotopoulos, C
AF Devlin, Angela M.
   Panagiotopoulos, Constadina
TI Metabolic side effects and pharmacogenetics of second-generation
   antipsychotics in children
SO PHARMACOGENOMICS
LA English
DT Review
DE cardiometabolic dysfunction; children; gene variants; second-generation
   antipsychotics; side effects; weight gain
ID INDUCED WEIGHT-GAIN; INTIMA-MEDIA THICKNESS; EARLY-ONSET SCHIZOPHRENIA;
   CORONARY-HEART-DISEASE; 5-HT2C RECEPTOR GENE; CARDIOVASCULAR RISK;
   BLOOD-PRESSURE; YOUNG FINNS; METHYLENETETRAHYDROFOLATE REDUCTASE;
   CARDIOMETABOLIC RISK
AB Second-generation antipsychotics (SGAs) are increasingly being used to treat children for a range of mental health conditions, for example, anxiety disorder, attention deficit hyperactivity disorder and bipolar disorder. SGA treatment is associated with weight gain and cardiometabolic side effects such as dyslipidemia, insulin resistance and elevated blood pressure, in some, but not all children. This review provides an overview of the potential role of pharmacogenomics in predisposing a child to unhealthy weight gain and cardiometabolic side effects with SGA treatment. Specifically, the review includes a synopsis of the evidence for cardiometabolic side effects in SGA-treated children, illustrating the extent and depth of the problem; summarizes the potential long-term consequences of developing cardiometabolic risk during childhood and highlights genetic variants that may be useful in predicting cardiometabolic side effects in SGA-treated children.
C1 [Devlin, Angela M.; Panagiotopoulos, Constadina] Univ British Columbia, Child & Family Res Inst, Dept Pediat, Vancouver, BC V5Z 4H4, Canada.
C3 University of British Columbia; Child & Family Research Institute
RP Devlin, AM (corresponding author), Univ British Columbia, Child & Family Res Inst, Dept Pediat, 272-950 West 28th Ave, Vancouver, BC V5Z 4H4, Canada.
EM adevlin@cfri.ubc.ca
RI Panagiotopoulos, Constadina/AAO-6827-2020
OI Panagiotopoulos, Constadina/0000-0002-1379-7472; Devlin,
   Angela/0000-0002-1390-6587
FU Canadian Institute of Health Research [MOP-133399]; Natural Sciences and
   Engineering Research Council of Canada [RG-PGP-2014-00066]; British
   Columbia Mental Health and Substance Use Services; Child and Family
   Research Institute
FX AM Devlin is supported by research grants from the Canadian Institute of
   Health Research (MOP-133399), Natural Sciences and Engineering Research
   Council of Canada (RG-PGP-2014-00066), and British Columbia Mental
   Health and Substance Use Services. She is also supported by an
   Investigator award from the Child and Family Research Institute. C
   Panagiotopoulos is supported by a research grant from British Columbia
   Mental Health and Substance Use Services. The authors have no other
   relevant affiliations or financial involvement with any organization or
   entity with a financial interest in or financial conflict with the
   subject matter or materials discussed in the manuscript apart from those
   disclosed.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alessi-Severini S, 2012, CAN J PSYCHIAT, V57, P52, DOI 10.1177/070674371205700109
   Allison DB, 1999, AM J PSYCHIAT, V156, P1686
   American Diabetes Association, 2007, Diabetes Care, V30 Suppl 1, pS42
   Annerbrink K, 2008, METABOLISM, V57, P708, DOI 10.1016/j.metabol.2008.01.012
   [Anonymous], JAMA
   Antoniades C, 2009, CIRCULATION, V119, P2507, DOI 10.1161/CIRCULATIONAHA.108.808675
   Arango C, 2014, J AM ACAD CHILD PSY, V53, P1179, DOI 10.1016/j.jaac.2014.08.009
   AXELROD J, 1958, J BIOL CHEM, V233, P702
   Bobo WV, 2013, JAMA PSYCHIAT, V70, P1067, DOI 10.1001/jamapsychiatry.2013.2053
   Calarge CA, 2009, PSYCHIAT GENET, V19, P320, DOI 10.1097/YPG.0b013e3283328e06
   Cecil JE, 2008, NEW ENGL J MED, V359, P2558, DOI 10.1056/NEJMoa0803839
   Ciccone MM, 2011, EUR J CARDIOV PREV R, V18, P831, DOI 10.1177/1741826711398180
   Cohen D, 2012, J CLIN PSYCHOPHARM, V32, P309, DOI 10.1097/JCP.0b013e3182549259
   Cooper WO, 2006, AMBUL PEDIATR, V6, P79, DOI 10.1016/j.ambp.2005.11.002
   Correia CT, 2010, PHARMACOGENOMICS J, V10, P418, DOI 10.1038/tpj.2009.63
   Correll CU, 2006, J CLIN PSYCHIAT, V67, P575, DOI 10.4088/JCP.v67n0408
   Correll CU, 2014, JAMA PSYCHIAT, V71, P1350, DOI 10.1001/jamapsychiatry.2014.1314
   Correll CU, 2009, JAMA-J AM MED ASSOC, V302, P1765, DOI 10.1001/jama.2009.1549
   Correll CU, 2004, AM J PSYCHIAT, V161, P414, DOI 10.1176/appi.ajp.161.3.414
   Cote AT, 2015, PHARMACOGENOMICS J, V15, P95, DOI 10.1038/tpj.2014.35
   Cote AT, 2015, ARTERIOSCL THROM VAS, V35, P1038, DOI 10.1161/ATVBAHA.114.305062
   Cote AT, 2013, J AM COLL CARDIOL, V62, P1309, DOI 10.1016/j.jacc.2013.07.042
   De Hert M, 2011, EUR PSYCHIAT, V26, P144, DOI 10.1016/j.eurpsy.2010.09.011
   Hert M, 2012, NAT REV ENDOCRINOL, V8, P114, DOI 10.1038/nrendo.2011.156
   De Luca V, 2007, INT J NEUROPSYCHOPH, V10, P697, DOI 10.1017/S1461145707007547
   Del Castillo Nicole, 2013, Clin Pharmacol Biopharm, V2, P110
   Devlin AM, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2011.68
   Di Pietro N, 2014, CAN MED ASSOC J, V186, P653, DOI 10.1503/cmaj.131604
   Doey T, 2007, CAN J PSYCHIAT, V52, P363, DOI 10.1177/070674370705200605
   Druss BG, 2001, ARCH GEN PSYCHIAT, V58, P565, DOI 10.1001/archpsyc.58.6.565
   Ellingrod VL, 2008, SCHIZOPHR RES, V98, P47, DOI 10.1016/j.schres.2007.09.030
   Ellingrod VL, 2012, J CLIN PSYCHOPHARM, V32, P261, DOI 10.1097/JCP.0b013e3182485888
   Fernández JR, 2004, J PEDIATR-US, V145, P439, DOI 10.1016/j.jpeds.2004.06.044
   FINKELSTEIN JD, 1990, J NUTR BIOCHEM, V1, P228, DOI 10.1016/0955-2863(90)90070-2
   FROSST P, 1995, NAT GENET, V10, P111, DOI 10.1038/ng0595-111
   Gebhardt S, 2010, J CLIN PHARM THER, V35, P207, DOI 10.1111/j.1365-2710.2009.01084.x
   Geerts CC, 2012, ANN MED, V44, P350, DOI 10.3109/07853890.2011.558520
   Girardet C, 2014, BBA-MOL BASIS DIS, V1842, P482, DOI 10.1016/j.bbadis.2013.05.004
   Glier MB, 2014, MOL NUTR FOOD RES, V58, P172, DOI 10.1002/mnfr.201200636
   Grundy SM, 2006, CURR OPIN CARDIOL, V21, P1, DOI 10.1097/01.hco.0000200416.65370.a0
   Hennekens CH, 2005, AM HEART J, V150, P1115, DOI 10.1016/j.ahj.2005.02.007
   Hirano Y, 2007, HYPERTENS RES, V30, P269, DOI 10.1291/hypres.30.269
   Hoekstra PJ, 2010, J CHILD ADOL PSYCHOP, V20, P473, DOI 10.1089/cap.2009.0071
   Htun NC, 2011, AM J HYPERTENS, V24, P1022, DOI 10.1038/ajh.2011.93
   Jassim G, 2011, PHARMACOPSYCHIATRY, V44, P15, DOI 10.1055/s-0030-1263174
   Juonala M, 2005, CIRCULATION, V112, P1486, DOI 10.1161/CIRCULATIONAHA.104.502161
   Juonala M, 2010, CIRCULATION, V122, P2514, DOI 10.1161/CIRCULATIONAHA.110.966465
   Kane JM, 2001, EUR NEUROPSYCHOPHARM, V11, P397, DOI 10.1016/S0924-977X(01)00109-2
   Karanges EA, 2014, AUST NZ J PSYCHIAT, V48, P917, DOI 10.1177/0004867414538675
   Klerk M, 2002, JAMA-J AM MED ASSOC, V288, P2023, DOI 10.1001/jama.288.16.2023
   Lachman HM, 1996, PHARMACOGENETICS, V6, P243, DOI 10.1097/00008571-199606000-00007
   Le J, 2010, CIRC-CARDIOVASC IMAG, V3, P8, DOI 10.1161/CIRCIMAGING.109.880070
   Leitch KK., 2007, Reaching for the top: a report by the advisor on healthy children youth
   Lett TAP, 2012, MOL PSYCHIATR, V17, P242, DOI 10.1038/mp.2011.109
   Li XR, 2004, CIRCULATION, V110, P3488, DOI 10.1161/01.CIR.0000149713.48317.27
   Loos RJF, 2008, NAT GENET, V40, P768, DOI 10.1038/ng.140
   Lorenz MW, 2007, CIRCULATION, V115, P459, DOI 10.1161/CIRCULATIONAHA.106.628875
   Lorenzo C, 2007, DIABETES CARE, V30, P8, DOI 10.2337/dc06-1414
   Maayan L, 2011, J CHILD ADOL PSYCHOP, V21, P517, DOI 10.1089/cap.2011.0015
   Magnussen CG, 2010, CIRCULATION, V122, P1604, DOI 10.1161/CIRCULATIONAHA.110.940809
   Malhotra AK, 2012, ARCH GEN PSYCHIAT, V69, P904, DOI 10.1001/archgenpsychiatry.2012.191
   Merikangas KR, 2010, J AM ACAD CHILD PSY, V49, P980, DOI 10.1016/j.jaac.2010.05.017
   Mittelman SD, 2010, J PEDIATR-US, V156, P592, DOI 10.1016/j.jpeds.2009.10.014
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Münzberg H, 2015, METABOLISM, V64, P13, DOI 10.1016/j.metabol.2014.09.010
   Nasrallah Henry A, 2004, J Clin Psychopharmacol, V24, pS7, DOI 10.1097/01.jcp.0000142282.62336.e9
   Natl High Blood Pressure Educ Prog, 2004, PEDIATRICS, V114, P555
   Newcomer John W, 2004, J Clin Psychopharmacol, V24, pS1, DOI 10.1097/01.jcp.0000142281.85207.d5
   Newton-Cheh C, 2009, NAT GENET, V41, P666, DOI 10.1038/ng.361
   Nielsen RE, 2014, J AM ACAD CHILD PSY, V53, P971, DOI 10.1016/j.jaac.2014.04.023
   Nurmi EL, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.26
   O'Donoghue B, 2014, EARLY INTERV PSYCHIA, V8, P276, DOI 10.1111/eip.12083
   Olfson M, 2006, ARCH GEN PSYCHIAT, V63, P679, DOI 10.1001/archpsyc.63.6.679
   Panagiotopoulos C, 2012, CAN J PSYCHIAT, V57, P34, DOI 10.1177/070674371205700107
   Panagiotopoulos C, 2010, J CAN ACAD CHILD ADO, V19, P124
   Panagiotopoulos C, 2009, CAN J PSYCHIAT, V54, P743, DOI 10.1177/070674370905401104
   Parsons B, 2009, SCHIZOPHR RES, V110, P103, DOI 10.1016/j.schres.2008.09.025
   Pringsheim T, 2011, DRUG SAFETY, V34, P651, DOI 10.2165/11592020-000000000-00000
   Qian XQ, 2007, EUR J HUM GENET, V15, P1239, DOI 10.1038/sj.ejhg.5201914
   Raitakari OT, 2003, JAMA-J AM MED ASSOC, V290, P2277, DOI 10.1001/jama.290.17.2277
   Ratzoni G, 2002, J AM ACAD CHILD PSY, V41, P337, DOI 10.1097/00004583-200203000-00014
   Ravyn D, 2013, SCHIZOPHR RES, V149, P1, DOI 10.1016/j.schres.2013.06.035
   Reynolds GP, 2002, LANCET, V359, P2086, DOI 10.1016/S0140-6736(02)08913-4
   Ronsley R, 2013, CAN J PSYCHIAT, V58, P361, DOI 10.1177/070674371305800608
   Safer DJ, 2004, J CLIN PSYCHOPHARM, V24, P429, DOI 10.1097/01.jcp.0000130558.86125.5b
   Schneider C, 2014, J PSYCHOPHARMACOL, V28, P615, DOI 10.1177/0269881114533599
   Shah AS, 2011, DIABETOLOGIA, V54, P722, DOI 10.1007/s00125-010-1974-7
   Sicras-Mainar A, 2008, EUR PSYCHIAT, V23, P100, DOI 10.1016/j.eurpsy.2007.07.005
   Sikich L, 2008, AM J PSYCHIAT, V165, P1420, DOI 10.1176/appi.ajp.2008.08050756
   Stewart SH, 2009, AM J HYPERTENS, V22, P87, DOI 10.1038/ajh.2008.321
   Takeuchi F, 2010, CIRCULATION, V121, P2302, DOI 10.1161/CIRCULATIONAHA.109.904664
   Tandon R, 2003, PSYCHONEUROENDOCRINO, V28, P1, DOI 10.1016/S0306-4530(02)00109-9
   TECOTT LH, 1995, NATURE, V374, P542, DOI 10.1038/374542a0
   Templeman Lucy A, 2005, Pharmacogenet Genomics, V15, P195, DOI 10.1097/01213011-200504000-00002
   Theisen FM, 2005, PSYCHIAT GENET, V15, P285, DOI 10.1097/00041444-200512000-00011
   Theisen FM, 2004, PSYCHIAT GENET, V14, P139, DOI 10.1097/00041444-200409000-00003
   Tracy RE, 1995, AM J MED SCI, V310, pS37, DOI 10.1097/00000441-199512000-00007
   Urbina EM, 2011, J CLIN HYPERTENS, V13, P332, DOI 10.1111/j.1751-7176.2011.00471.x
   van Winkel R, 2010, SCHIZOPHR RES, V121, P193, DOI 10.1016/j.schres.2010.05.030
   van Winkel R, 2010, INT CLIN PSYCHOPHARM, V25, P270, DOI 10.1097/YIC.0b013e32833bc60d
   Watkins BA, 2015, FRONT PSYCHOL, V5, DOI 10.3389/fpsyg.2014.01506
   Wong ICK, 2004, ARCH DIS CHILD, V89, P1131, DOI 10.1136/adc.2004.050468
NR 103
TC 15
Z9 17
U1 0
U2 16
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1462-2416
EI 1744-8042
J9 PHARMACOGENOMICS
JI Pharmacogenomics
PY 2015
VL 16
IS 9
BP 981
EP 996
DI 10.2217/pgs.15.55
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CM7IJ
UT WOS:000357864700008
PM 26107755
DA 2025-06-11
ER

PT J
AU Navarrete-Muñoz, EM
   Vioque, J
   Toledo, E
   Oncina-Canovas, A
   Martínez-González, MA
   Salas-Salvadó, J
   Corella, D
   Fitó, M
   Romaguera, D
   Alonso-Gómez, AM
   Wärnberg, J
   Martínez, JA
   Serra-Majem, L
   Estruch, R
   Tinahones, FJ
   Lapetra, J
   Pintó, X
   Tur, JA
   López-Miranda, J
   Bueno-Cavanillas, A
   Matía-Martín, P
   Daimiel, L
   Sánchez, VM
   Vidal, J
   Blanco, AID
   Ros, E
   Diez-Espino, J
   Babio, N
   Fernandez-Carrion, R
   Castañer, O
   Colom, A
   Compañ-Gabucio, L
   Lete, IS
   Crespo-Oliva, E
   Abete, I
   Tomaino, L
   Casas, R
   Fernandez-Garcia, JC
   Santos-Lozano, JM
   Sarasa, I
   Garcia-Rios, JMA
   Martín-Pelaez, S
   Ruiz-Canela, M
   Díaz-López, A
   Martinez-Lacruz, R
   Zomeño, MD
   Rayó, E
   Selles, CG
   Canudas, S
   Goday, A
   García-de-la-Hera, M
AF Navarrete-Munoz, Eva-Maria
   Vioque, Jesus
   Toledo, Estefania
   Oncina-Canovas, Alejando
   Angel Martinez-Gonzalez, Miguel
   Salas-Salvado, Jordi
   Corella, Dolores
   Fito, Montserrat
   Romaguera, Dora
   Alonso-Gomez, Angel M.
   Warnberg, Julia
   Alfredo Martinez, J.
   Serra-Majem, Luis
   Estruch, Ramon
   Tinahones, Francisco J.
   Lapetra, Jose
   Pinto, Xavier
   Tur, Josep A.
   Lopez-Miranda, Jose
   Bueno-Cavanillas, Aurora
   Matia-Martin, Pilar
   Daimiel, Lidia
   Martin Sanchez, Vicente
   Vidal, Josep
   de Cos Blanco, Ana Isabel
   Ros, Emili
   Diez-Espino, Javier
   Babio, Nancy
   Fernandez-Carrion, Rebeca
   Castaner, Olga
   Colom, Antoni
   Compan-Gabucio, Laura
   Salaverria Lete, Itziar
   Crespo-Oliva, Edelys
   Abete, Itziar
   Tomaino, Laura
   Casas, Rosa
   Carlos Fernandez-Garcia, Jose
   Manuel Santos-Lozano, Jose
   Sarasa, Iziar
   Antonio Garcia-Rios, Jose M.
   Martin-Pelaez, Sandra
   Ruiz-Canela, Miguel
   Diaz-Lopez, Andres
   Martinez-Lacruz, Raul
   Dolors Zomeno, Maria
   Rayo, Elena
   Gisbert Selles, Cristina
   Canudas, Silvia
   Goday, Albert
   Garcia-de-la-Hera, Manoli
TI Dietary folate intake and metabolic syndrome in participants of
   PREDIMED-Plus study: a cross-sectional study
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Folate; Cardiometabolic risk; Metabolic syndrome score; Diabetes;
   Cholesterol
ID FOLIC-ACID SUPPLEMENTATION; INSULIN-RESISTANCE; HOMOCYSTEINE; ADULTS;
   METAANALYSIS; PREVALENCE; ASSOCIATION; POPULATION; DISEASES; STRESS
AB Purpose We examined the association between dietary folate intake and a score of MetS (metabolic syndrome) and its components among older adults at higher cardiometabolic risk participating in the PREDIMED-Plus trial. Methods A cross-sectional analysis with 6633 with overweight/obesity participants with MetS was conducted. Folate intake (per 100 mcg/day and in quintiles) was estimated using a validated food frequency questionnaire. We calculated a MetS score using the standardized values as shown in the formula: [(body mass index + waist-to-height ratio)/2] + [(systolic blood pressure + diastolic blood pressure)/2] + plasma fasting glucose-HDL cholesterol + plasma triglycerides. The MetS score as continuous variable and its seven components were the outcome variables. Multiple robust linear regression using MM-type estimator was performed to evaluate the association adjusting for potential confounders. Results We observed that an increase in energy-adjusted folate intake was associated with a reduction of MetS score (beta for 100 mcg/day = - 0.12; 95% CI: - 0.19 to - 0.05), and plasma fasting glucose (beta = - 0.03; 95% CI: - 0.05 to - 0.02) independently of the adherence to Mediterranean diet and other potential confounders. We also found a positive association with HDL-cholesterol (beta = 0.07; 95% CI: 0.04-0.10). These associations were also observed when quintiles of energy-adjusted folate intake were used instead. Conclusion This study suggests that a higher folate intake may be associated with a lower MetS score in older adults, a lower plasma fasting glucose, and a greater HDL cholesterol in high-risk cardio-metabolic subjects.
C1 [Navarrete-Munoz, Eva-Maria] Miguel Hernandez Univ, Dept Surg & Pathol, Grp Invest Terapia Ocupac InTeO, Alicante 03550, Spain.
   [Vioque, Jesus; Bueno-Cavanillas, Aurora; Martin Sanchez, Vicente; Garcia-de-la-Hera, Manoli] Inst Hlth Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.
   [Vioque, Jesus; Oncina-Canovas, Alejando; Compan-Gabucio, Laura; Garcia-de-la-Hera, Manoli] Univ Miguel Hernandez, Nutr Epidemiol Unit, ISABIAL UMH, Alicante, Spain.
   [Toledo, Estefania; Angel Martinez-Gonzalez, Miguel; Salas-Salvado, Jordi; Corella, Dolores; Fito, Montserrat; Romaguera, Dora; Alonso-Gomez, Angel M.; Warnberg, Julia; Alfredo Martinez, J.; Serra-Majem, Luis; Estruch, Ramon; Tinahones, Francisco J.; Lapetra, Jose; Pinto, Xavier; Tur, Josep A.; Lopez-Miranda, Jose; de Cos Blanco, Ana Isabel; Ros, Emili; Diez-Espino, Javier; Babio, Nancy; Fernandez-Carrion, Rebeca; Castaner, Olga; Crespo-Oliva, Edelys; Abete, Itziar; Tomaino, Laura; Casas, Rosa; Carlos Fernandez-Garcia, Jose; Manuel Santos-Lozano, Jose; Antonio Garcia-Rios, Jose M.; Ruiz-Canela, Miguel; Diaz-Lopez, Andres; Martinez-Lacruz, Raul; Dolors Zomeno, Maria; Canudas, Silvia; Goday, Albert] Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Inst Hlth Carlos III, Madrid, Spain.
   [Toledo, Estefania; Angel Martinez-Gonzalez, Miguel; Diez-Espino, Javier; Ruiz-Canela, Miguel] Univ Navarra, Dept Prevent Med & Publ Hlth, IdiSNA, Pamplona, Spain.
   [Angel Martinez-Gonzalez, Miguel] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
   [Salas-Salvado, Jordi; Babio, Nancy; Diaz-Lopez, Andres; Canudas, Silvia] Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Unitat Nutr, Reus, Spain.
   [Salas-Salvado, Jordi; Babio, Nancy; Diaz-Lopez, Andres; Canudas, Silvia] Univ Hosp St Joan de Reus, Nutr Unit, Reus, Spain.
   [Salas-Salvado, Jordi; Babio, Nancy; Diaz-Lopez, Andres; Canudas, Silvia] Inst Invest Sanitaria Pere Virgili IISPV, Reus, Spain.
   [Corella, Dolores; Fernandez-Carrion, Rebeca; Martinez-Lacruz, Raul] Univ Valencia, Dept Prevent Med, Valencia, Spain.
   [Fito, Montserrat; Castaner, Olga; Dolors Zomeno, Maria; Goday, Albert] Inst Hosp del Mar Invest Med Municipal Invest Med, Unit Cardiovasc Risk & Nutr, Barcelona, Spain.
   [Romaguera, Dora; Tur, Josep A.; Colom, Antoni; Rayo, Elena] Univ Hosp Son Espases, Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca, Spain.
   [Alonso-Gomez, Angel M.; Salaverria Lete, Itziar] Univ Basque Country UPV EHU, Araba Univ Hosp, Bioaraba Hlth Res Inst, Osakidetza Basque Hlth Serv, Vitoria, Spain.
   [Warnberg, Julia; Crespo-Oliva, Edelys] Univ Malaga, Sch Hlth Sci, Dept Nursing, Inst Biomed Res Malaga IBIMA, Malaga, Spain.
   [Alfredo Martinez, J.; Abete, Itziar] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona, Spain.
   [Serra-Majem, Luis; Tomaino, Laura] Univ Palmas Gran Canaria, Res Inst Biomed & Hlth Sci IUIBS, Las Palmas Gran Canaria, Spain.
   [Serra-Majem, Luis; Tomaino, Laura] Ctr Hosp Univ Insular Materno Infantil CHUIMI, Canarian Hlth Serv, Las Palmas Gran Canaria, Spain.
   [Estruch, Ramon; Casas, Rosa] Univ Barcelona, Hosp Clin, Inst Investigac Biomed August Pi Sunyer IDIBAPS, Dept Internal Med, Barcelona, Spain.
   [Tinahones, Francisco J.; Carlos Fernandez-Garcia, Jose] Univ Malaga, Virgen Victoria Hosp, Inst Invest Biomed Malaga IBIMA, Dept Endocrinol, Malaga, Spain.
   [Lapetra, Jose; Manuel Santos-Lozano, Jose] Dist Sanitario Atenc Primaria Sevilla, Res Unit, Dept Family Med, Seville, Spain.
   [Pinto, Xavier; Sarasa, Iziar] Hosp Univ Bellvitge, Hospitalet Llobregat, Lipids & Vasc Risk Unit, Internal Med, Barcelona, Spain.
   [Tur, Josep A.] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain.
   [Lopez-Miranda, Jose; Antonio Garcia-Rios, Jose M.] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba Imib, Dept Internal Med, Cordoba, Spain.
   [Bueno-Cavanillas, Aurora; Martin-Pelaez, Sandra] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain.
   [Matia-Martin, Pilar] Inst Invest Sanitaria Hosp Clin San Carlos IdISSC, Dept Endocrinol & Nutr, Madrid, Spain.
   [Daimiel, Lidia] IMDEA Food, CEI UAM CSIC, Precis Nutr & Obes Program, Nutr Control Epigenom Grp, Madrid, Spain.
   [Martin Sanchez, Vicente] Univ Leon, Inst Biomed IBIOMED, Leon, Spain.
   [Vidal, Josep] Inst Salud Carlos III ISCIII, CIBER Diabet & Enfermedades Metab CIBERDEM, Madrid, Spain.
   [Vidal, Josep] Univ Barcelona, Hosp Clin, Inst Investigac Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol, Barcelona, Spain.
   [de Cos Blanco, Ana Isabel] Univ Autonoma, Hosp Fdn Jimenez Diaz, Inst Invest Biomed IISFJD, Dept Endocrinol & Nutr, Madrid, Spain.
   [Ros, Emili] Hosp Clin Barcelona, Inst Investigac Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol & Nutr, Lipid Clin, Barcelona, Spain.
   [Diez-Espino, Javier] Serv Navarro Salud Osasunbidea, Gerencia Atenc Primaria, Pamplona, Spain.
   [Tomaino, Laura] Univ Milan, Dept Clin & Community Hlth DISCCO, Milan, Italy.
   [Gisbert Selles, Cristina] Ctr Salud San Vicente Raspeig, Alicante, Spain.
   [Vioque, Jesus] Univ Miguel Hernandez, Dept Salud Publ, Campus San Juan,Ctra Nacl 332 S-N, Sant Joan dAlacant 03550, Spain.
C3 Universidad Miguel Hernandez de Elche; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERESP; General University Hospital of Alicante;
   Universidad Miguel Hernandez de Elche; Universitat d'Alacant; Instituto
   de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL); CIBER -
   Centro de Investigacion Biomedica en Red; CIBEROBN; University of
   Navarra; Harvard University; Harvard T.H. Chan School of Public Health;
   Universitat Rovira i Virgili; Universitat Rovira i Virgili; Institut
   d'Investigacio Sanitaria Pere Virgili (IISPV); University of Valencia;
   Institut Investigacio Sanitaria Illes Balears (IdISBa); Hospital
   Universitari Son Espases; Bioaraba Health Research Institute; University
   Hospital of Araba; University of Basque Country; Instituto de
   Investigacion Biomedica de Malaga y Plataforma en Nanomedicina (IBIMA);
   Universidad de Malaga; University of Navarra; Universidad de Las Palmas
   de Gran Canaria; University of Barcelona; Hospital Clinic de Barcelona;
   IDIBAPS; Universidad de Malaga; Instituto de Investigacion Biomedica de
   Malaga y Plataforma en Nanomedicina (IBIMA); Institut d'Investigacio
   Biomedica de Bellvitge (IDIBELL); Bellvitge University Hospital;
   University of Barcelona; Universitat de les Illes Balears; Universidad
   de Cordoba; University of Granada; Consejo Superior de Investigaciones
   Cientificas (CSIC); IMDEA Food Institute; Universidad de Leon; CIBER -
   Centro de Investigacion Biomedica en Red; CIBERDEM; University of
   Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Fundacion Jimenez
   Diaz; Autonomous University of Madrid; University of Barcelona; Hospital
   Clinic de Barcelona; IDIBAPS; Servicio Navarro de Salud - Osasunbidea;
   University of Milan; Universidad Miguel Hernandez de Elche
RP Vioque, J (corresponding author), Inst Hlth Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.; Vioque, J (corresponding author), Univ Miguel Hernandez, Nutr Epidemiol Unit, ISABIAL UMH, Alicante, Spain.; Vioque, J (corresponding author), Univ Miguel Hernandez, Dept Salud Publ, Campus San Juan,Ctra Nacl 332 S-N, Sant Joan dAlacant 03550, Spain.
EM vioque@umh.es
RI Vioque, Jesus/A-1066-2008; MARTIN-PELAEZ, SANDRA/G-4945-2015; Babio,
   Nancy/AAN-2715-2020; Navarrete-Muñoz, Eva/F-1666-2011; Tur,
   Josep/AAE-5748-2020; Castaner, Olga/F-1533-2013; Pintó,
   Xavier/AGI-4297-2022; ALONSO GOMEZ, ANGEL/HLG-2476-2023; Gabucio,
   Laura/AAN-6068-2020; Martinez, Juan/GXM-4393-2022; Estruch,
   Ramon/AAZ-3723-2020; Lopez-Miranda, Jose/Y-8306-2019; Vidal,
   Josep/MIK-6936-2025; Fernandez-Carrion, Rebeca/AAA-5713-2019; Lapetra,
   Jose/F-2552-2015; Garcia de la Hera, Manuela/N-8908-2019; Tinahones,
   Francisco/AAB-2882-2020; Toledo, Estefania/H-6211-2014; Oncina Canovas,
   Alejandro/KOD-0906-2024; Romaguera, Dora/ABE-7004-2020; Corella,
   Dolores/L-9888-2014; Bueno-Cavanillas, Aurora/O-1513-2015; Ruiz-Canela,
   Miguel/JYP-1794-2024; Martinez-Gonzalez, Miguel/AAE-7669-2019; Colom
   Fernandez, Antoni/JHU-4849-2023; Casas, Rosa/ABD-1915-2020;
   Fernandez-Garcia, Jose/B-5312-2013; Fito Colomer, Montse/C-1822-2012;
   Warnberg, Julia/G-1390-2011; Ruiz-Canela, Miguel/I-7738-2016; Martin,
   Vicente/A-1597-2008; Daimiel-Ruiz, Lidia Angeles/M-7779-2014; Canudas,
   Silvia/K-4184-2014; Salas-Salvado, Jordi/C-7229-2017
OI Oncina Canovas, Alejandro/0000-0003-4652-0565; Casas,
   Rosa/0000-0002-0211-9166; Vioque, Jesus/0000-0002-2284-148X; Fito
   Colomer, Montse/0000-0002-1817-483X; Lopez-Miranda,
   Jose/0000-0002-8844-0718; BABIO SANCHEZ, NANCY/0000-0003-3527-5277;
   Compan Gabucio, Laura M/0000-0001-5324-1535; Castaner Nino,
   Olga/0000-0003-3169-997X; Navarrete-Munoz, Eva
   Maria/0000-0002-1494-5676; MARTIN PELAEZ, SANDRA/0000-0002-2193-3913;
   Vidal Cortada, Josep/0000-0002-4564-4518; Warnberg,
   Julia/0000-0002-8408-316X; Ruiz-Canela, Miguel/0000-0002-7684-2787;
   Pinto Sala, Xavier/0000-0002-2216-2444; Tinahones, Francisco
   J/0000-0001-6871-4403; Zomeno, M. Dolores/0000-0003-1280-7680; Martin,
   Vicente/0000-0003-0552-2804; Daimiel-Ruiz, Lidia
   Angeles/0000-0001-9898-6629; Canudas, Silvia/0000-0002-5630-1588;
   Salas-Salvado, Jordi/0000-0003-2700-7459; Gamez/0000-0002-9362-6947;
   Garcia de la Hera, Manuela/0000-0001-5742-2704; Diaz-Lopez,
   Andres/0000-0002-7500-5629; Crespo Oliva, Edelys/0009-0001-2103-925X
FU Cohorte PREDIMED-Plus grant; European Research Council [340918];
   Especial Action Project; Recercaixa grant [2013ACUP00194]; Consejeria de
   Salud de la Junta de Andalucia [PI0458/2013, PS0358/2016, PI0137/2018];
   Generalitat Valenciana [PROMETEO/2017/017]; SEMERGEN grant; European
   Regional Development Fund [CB06/03, CB12/03]; International Nut & Dried
   Fruit Council-FESNAD [201302]; AstraZeneca Young Investigators Award in
   Category of Obesity [T2D 2017]; EU-COST Action [CA16112]; Balearic
   Islands Government [35/2011]; Balearic Islands Health Research Institute
   (IDISBA); ICREA under the ICREA Academia programme; Instituto de Salud
   Carlos III - Fondo Europeo de Desarrollo Regional-FEDER [PI13/00673,
   PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184,
   PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618,
   PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374]; 
   [PI16/00473];  [PI16/00662];  [PI16/01873];  [PI16/01094]; 
   [PI16/00501];  [PI16/00533];  [PI16/00381];  [PI16/00366]; 
   [PI16/01522];  [PI16/01120];  [PI17/00764];  [PI17/01183]; 
   [PI17/00855];  [PI17/01347];  [PI17/00525];  [PI17/01827]; 
   [PI17/00532];  [PI17/00215];  [PI17/01441];  [PI17/00508]; 
   [PI17/01732];  [PI17/00926]
FX The PREDIMED-Plus trial was supported by grants from the Instituto de
   Salud Carlos III, co-financed by the Fondo Europeo de Desarrollo
   Regional-FEDER including the following projects: PI13/00673, PI13/00492,
   PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728,
   PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696,
   PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI16/00473, PI16/00662,
   PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366,
   PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347,
   PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508,
   PI17/01732, and PI17/00926; the Cohorte PREDIMED-Plus grant; the
   European Research Council (Advanced Research Grant 2013-2018, 340918) to
   M.A.M.-G., the Especial Action Project entitled: Implementacion y
   evaluacion de una intervencion intensiva sobre la actividad fisica
   Cohorte PREDIMED-Plus grant to J.S.-S., the Recercaixa grant to J.S.-S.
   (2013ACUP00194), grants from the Consejeria de Salud de la Junta de
   Andalucia (PI0458/2013, PS0358/2016, and PI0137/2018), a grant from the
   Generalitat Valenciana (PROMETEO/2017/017), a SEMERGEN grant, and funds
   from the European Regional Development Fund (CB06/03 and CB12/03), The
   International Nut & Dried Fruit Council-FESNAD (Long-term effects of an
   energy-restricted Mediterranean diet on mortality and cardiovascular
   disease 2014-2015, No. 201302) [M.A.M.G.]; the AstraZeneca Young
   Investigators Award in Category of Obesity and T2D 2017 [D.R.], EU-COST
   Action CA16112, Grant of support to research groups no. 35/2011 from the
   Balearic Islands Government, Grants from Balearic Islands Health
   Research Institute (IDISBA). This work is partially supported by ICREA
   under the ICREA Academia programme. None of the funding sources took
   part in the design, collection, analysis, or interpretation of the data
   or in the decision to submit the manuscript for publication.
CR Akbari M, 2018, HORM METAB RES, V50, P93, DOI 10.1055/s-0043-125148
   Ansarimoghaddam A, 2018, DIABETES METAB SYND, V12, P195, DOI 10.1016/j.dsx.2017.11.004
   Athyros VG, 2005, CURR MED RES OPIN, V21, P1157, DOI 10.1185/030079905X53333
   Bailey RL, 2017, AM J CLIN NUTR, V105, P1336, DOI 10.3945/ajcn.116.148775
   Bhatnagar A, 2017, CIRC RES, V121, P162, DOI 10.1161/CIRCRESAHA.117.306458
   Croux C., 2003, ROBUST STANDARD ERRO
   da Silva RP, 2014, BIOFACTORS, V40, P277, DOI 10.1002/biof.1154
   de Bree A, 2007, AM J CLIN NUTR, V86, P610, DOI 10.1093/ajcn/86.3.610
   Ebara S, 2017, CONGENIT ANOM, V57, P138, DOI 10.1111/cga.12233
   European Food Safety Authority, 2017, Dietary Reference Values for Nutrients Summary Report. EFS3, DOI DOI 10.2903/SP.EFSA.2017.E15121
   Fernández-Ballarth JD, 2010, BRIT J NUTR, V103, P1808, DOI 10.1017/S0007114509993837
   Ford ES, 2010, J DIABETES, V2, P180, DOI 10.1111/j.1753-0407.2010.00078.x
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Franks PW, 2004, DIABETES CARE, V27, P1187, DOI 10.2337/diacare.27.5.1187
   Grandl G, 2018, SEMIN IMMUNOPATHOL, V40, P215, DOI 10.1007/s00281-017-0666-5
   Guallar-Castillón P, 2014, REV ESP CARDIOL, V67, P367, DOI [10.1016/j.rec.2013.08.014, 10.1016/j.recesp.2013.08.014]
   Guay SP, 2012, EPIGENOMICS-UK, V4, P623, DOI [10.2217/epi.12.62, 10.2217/EPI.12.62]
   Kanagasabai T, 2019, METAB SYNDR RELAT D, V17, P29, DOI 10.1089/met.2018.0080
   Kwan GF, 2016, CIRCULATION, V133, P2561, DOI 10.1161/CIRCULATIONAHA.116.008731
   Lind MV, 2019, AM J CLIN NUTR, V109, P29, DOI 10.1093/ajcn/nqy234
   Lucock M, 2000, MOL GENET METAB, V71, P121, DOI 10.1006/mgme.2000.3027
   Martínez-González MA, 2019, INT J EPIDEMIOL, V48, P387, DOI 10.1093/ije/dyy225
   Mataix Verdu J, 2003, Mataix and others, V4th
   Molina L, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0168148
   Moreiras O., 2005, Tablas de composicion de alimentos
   Motamed Soudabe, 2013, N Am J Med Sci, V5, P377, DOI 10.4103/1947-2714.114171
   Olza J, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102328
   Pravenec M, 2013, AM J HYPERTENS, V26, P135, DOI 10.1093/ajh/hps015
   Ramos-Lopez O, 2018, NUTR RES, V50, P53, DOI 10.1016/j.nutres.2017.11.007
   Raposo L, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4471-9
   Roth GA, 2017, J AM COLL CARDIOL, V70, P1, DOI 10.1016/j.jacc.2017.04.052
   Salas-Salvadó J, 2019, DIABETES CARE, V42, P777, DOI 10.2337/dc18-0836
   Scaglione F, 2014, XENOBIOTICA, V44, P480, DOI 10.3109/00498254.2013.845705
   Schröder H, 2011, J NUTR, V141, P1140, DOI 10.3945/jn.110.135566
   Selhub J, 2002, J Nutr Health Aging, V6, P39
   Setola E, 2004, EUR J ENDOCRINOL, V151, P483, DOI 10.1530/eje.0.1510483
   Sheu WHH, 2005, LIFE SCI, V76, P2137, DOI 10.1016/j.lfs.2004.12.002
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Solini A, 2006, INT J OBESITY, V30, P1197, DOI 10.1038/sj.ijo.0803265
   Song YQ, 2009, DIABETES, V58, P1921, DOI 10.2337/db09-0087
   Sreckovic B, 2017, DIABETES METAB SYND, V11, P179, DOI 10.1016/j.dsx.2016.08.026
   Stanhewicz AE, 2017, NUTR REV, V75, P61, DOI 10.1093/nutrit/nuw053
   Stanhewicz AE, 2015, CLIN SCI, V129, P159, DOI 10.1042/CS20140821
   Steluti J, 2017, EUR J CLIN NUTR, V71, P1173, DOI 10.1038/ejcn.2017.60
   Suh E, 2016, MOLEC NUTRITION, P513, DOI 10.1016/B978-0-12-801816-3.00036-4
   Talari HR, 2016, ANN NUTR METAB, V69, P41, DOI 10.1159/000448295
   Viitasalo A, 2014, DIABETOLOGIA, V57, P940, DOI 10.1007/s00125-014-3172-5
   Wald DS, 2006, BMJ-BRIT MED J, V333, P1114, DOI 10.1136/bmj.39000.486701.68
   Wang WW, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00585
   Willett W., 1998, nutritional epidemiology, V2nd, P74, DOI [10.1093/acprof:oso/9780195122978.003.05, DOI 10.1093/ACPROF:OSO/9780195122978.003.05]
   Willett WC, 1997, AM J CLIN NUTR, V65, P1220, DOI 10.1093/ajcn/65.4.1220S
   WU Y, 2020, INT J FOOD SCI NUTR
   Zhao JV, 2018, ANN EPIDEMIOL, V28, P249, DOI 10.1016/j.annepidem.2018.02.001
NR 53
TC 15
Z9 16
U1 1
U2 23
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD MAR
PY 2021
VL 60
IS 2
BP 1125
EP 1136
DI 10.1007/s00394-020-02364-4
EA AUG 2020
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA QK8PU
UT WOS:000562326900001
PM 32833162
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kim, Y
   Kim, HY
AF Kim, Yunmi
   Kim, Hyun-Young
TI Association Between Depression and Metabolic Syndrome in Korean Adults:
   Data From the 2014 and 2016 Korea National Health and Nutrition
   Examination Survey
SO ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH
LA English
DT Article
DE adult; depression; Korean; metabolic syndrome; PHQ-9
ID QUALITY-OF-LIFE; QUESTIONNAIRE PHQ-9; PREVALENCE; MORTALITY; SYMPTOMS;
   OBESITY; RISK
AB This study aimed to examine the association of depression with metabolic syndrome and to investigate levels of awareness and treatment of depression in Korean adults. We analyzed data extracted from the Korea National Health and Nutrition Examination Survey (2014 and 2016) using the Patient Health Questionnaire-9 depression screening instrument. Among the survey participants, 10 459 were selected for data analysis. Of them, 7.2% had depression, 24.4% had metabolic syndrome, and 10.0% had both depression and metabolic syndrome. Among those with depression, 33.1% were aware of their condition and 25.7% received treatment, with significant differences found between those with and without metabolic syndrome. The mean Patient Health Questionnaire-9 scores significantly increased with the number of metabolic syndrome components (F = 6.06, P = <.001). In logistic regression analysis, the odds ratio (OR) for depression with metabolic syndrome was 1.41 (95% confidence interval [CI] = 1.12-1.76). For the number of metabolic syndrome components, having 2 (OR = 1.37, 95% CI = 1.01-1.86), 3 (OR = 1.57, 95% CI = 1.12-2.21), 4 (OR = 1.95, 95% CI = 1.32-2.87), and 5 (OR = 2.18, 95% CI = 1.38-3.46) conditions significantly increased the OR for depression. Including depression in the management of metabolic syndrome could help make people with depression more aware of their condition.
C1 [Kim, Yunmi] Eulji Univ, Seongnam Si, South Korea.
   [Kim, Hyun-Young] Jeonju Univ, Jeonju Si, South Korea.
C3 Eulji University; Jeonju University
RP Kim, HY (corresponding author), Jeonju Univ, Dept Nursing, 303 Cheonjam Ro, Jeonju Si 55069, South Korea.
EM flowhykim@gmail.com
CR Almeida OP, 2009, AM J GERIAT PSYCHIAT, V17, P889, DOI 10.1097/JGP.0b013e3181b047e3
   [Anonymous], 2017, HLTH GLANC 2017 OECD
   Bartoli F, 2016, INT J GERIATR PSYCH, V31, P829, DOI 10.1002/gps.4397
   Tran BT, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-016-3936-6
   Cho MJ, 2015, PSYCHIAT INVEST, V12, P164, DOI 10.4306/pi.2015.12.2.164
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Nguyen HA, 2017, NEPHRON, V136, P127, DOI 10.1159/000455750
   Inoue T, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-73
   Jung KJ, 2017, ASIA-PAC J PUBLIC HE, V29, P122, DOI 10.1177/1010539516688082
   Jung SJ, 2015, BMC PUBLIC HEALTH, V15, DOI 10.1186/s12889-015-2402-1
   Jung Y.H., 2017, KOREAN J FAM PRACT, V7, P308, DOI [10.21215/kjfp.2017.7.3.308, DOI 10.21215/KJFP.2017.7.3.308]
   Kim EY, 2015, J AFFECT DISORDERS, V188, P14, DOI 10.1016/j.jad.2015.08.024
   Kim YJ, 2015, ALLERGY ASTHMA RESPI, V3, P173, DOI 10.4168/aard.2015.3.3.173
   Kim Y, 2014, EPIDEMIOL HEALTH, V36, DOI 10.4178/epih/e2014002
   Liaw FY, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/586251
   Liu Y, 2017, J AFFECT DISORDERS, V217, P190, DOI 10.1016/j.jad.2017.04.009
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Ministry of Health and Welfare, 2012, 2011 EP SURV MEN DIS
   Ministry of Health and Welfare in Korea, PRIM CAR CTR CHRON D
   Moriarty AS, 2015, GEN HOSP PSYCHIAT, V37, P567, DOI 10.1016/j.genhosppsych.2015.06.012
   Nebhinani N., 2016, J MENT HEALTH HUM BE, V21, P91, DOI DOI 10.4103/0971-8990.193426
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Park SJ, 2016, J AFFECT DISORDERS, V205, P393, DOI 10.1016/j.jad.2016.08.022
   Rethorst CD, 2017, PSYCHOL MED, V47, P2414, DOI 10.1017/S0033291717000897
   Rhee SJ, 2014, PROG NEURO-PSYCHOPH, V54, P223, DOI 10.1016/j.pnpbp.2014.06.006
   Shin C, 2017, J KOREAN MED SCI, V32, P1861, DOI 10.3346/jkms.2017.32.11.1861
   The Korean Society of Hypertension, BLOOD PRESS MON GUID
   Wang Q, 2017, INT J CARDIOL, V230, P461, DOI 10.1016/j.ijcard.2016.12.084
   Wang WZ, 2014, GEN HOSP PSYCHIAT, V36, P539, DOI 10.1016/j.genhosppsych.2014.05.021
   Weber-Hamann B, 2006, PSYCHONEUROENDOCRINO, V31, P347, DOI 10.1016/j.psyneuen.2005.08.014
   Wittayanukorn S, 2014, GEN HOSP PSYCHIAT, V36, P330, DOI 10.1016/j.genhosppsych.2013.12.009
   Yu SS, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-016-3913-0
NR 32
TC 12
Z9 13
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1010-5395
EI 1941-2479
J9 ASIA-PAC J PUBLIC HE
JI Asia-Pac. J. Public Health
PD JAN
PY 2019
VL 31
IS 1
BP 18
EP 29
DI 10.1177/1010539518813704
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA HK1SL
UT WOS:000457686700003
PM 30466293
DA 2025-06-11
ER

PT J
AU Hung, CI
   Liu, CY
   Hsiao, MC
   Yu, NW
   Chu, CL
AF Hung, Ching-I
   Liu, Chia-Yih
   Hsiao, Mei-Chun
   Yu, Nan-Wen
   Chu, Chun-Lin
TI Metabolic syndrome among psychiatric outpatients with mood and anxiety
   disorders
SO BMC PSYCHIATRY
LA English
DT Article
DE Bipolar disorder; Depression; Anxiety; Metabolic syndrome
ID BIPOLAR DISORDER; HOSPITAL ANXIETY; DEPRESSION; ASSOCIATION; PREVALENCE;
   COOCCURRENCE; SYMPTOMS; RISK
AB Background: Few studies have simultaneously compared the impacts of pharmacotherapy and mental diagnoses on metabolic syndrome (MetS) among psychiatric outpatients with mood and anxiety disorders. This study aimed to investigate the impacts of pharmacotherapy and mental diagnoses on MetS and the prevalence of MetS among these patients.
   Methods: Two-hundred and twenty-nine outpatients (men/women = 85/144) were enrolled from 1147 outpatients with mood and anxiety disorders by systematic sampling. Psychiatric disorders and MetS were diagnosed using the Structured Clinical Interview for DSM-IV-TR and the new International Diabetics Federation definition, respectively. The numbers of antipsychotics, mood stabilizers, and antidepressants being taken were recorded. Logistic regression was used to investigate the impacts of pharmacotherapy and psychiatric diagnoses on MetS.
   Results: Among 229 subjects, 51 (22.3%) fulfilled the criteria for MetS. The prevalence of MetS was highest in the bipolar I disorder (46.7%) patients, followed by bipolar II disorder (25.0%), major depressive disorder (22.0%), anxiety-only disorders (16.7%), and no mood and/or anxiety disorders (14.3%). The percentages of MetS among the five categories were correlated with those of the patients being treated with antipsychotics and mood stabilizers. Use of antipsychotics and/or mood stabilizers independently predicted a higher risk of MetS after controlling for demographic variables and psychiatric diagnoses. When adding body mass index (BMI) as an independent variable in the regression model, BMI became the most significant factor to predict MetS.
   Conclusion: BMI was found to be an important factor related to MetS. Pharmacotherapy might be one of underlying causes of elevated BMI. The interactions among MetS, BMI, pharmacotherapy, and psychiatric diagnoses might need further research.
C1 [Hung, Ching-I; Liu, Chia-Yih; Hsiao, Mei-Chun; Yu, Nan-Wen; Chu, Chun-Lin] Chang Gung Mem Hosp Linkou, Dept Psychiat, Taoyuan 333, Taiwan.
   [Hung, Ching-I; Liu, Chia-Yih; Hsiao, Mei-Chun] Chang Gung Univ, Sch Med, Taoyuan, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University
RP Liu, CY (corresponding author), Chang Gung Mem Hosp Linkou, Dept Psychiat, 5 Fu Shing St, Taoyuan 333, Taiwan.
EM Liucy752@cgmh.org.tw
FU National Science Council of Taiwan (NSC) [97-2314-B-182A-017-MY2]
FX This study was supported in part by a grant from the National Science
   Council of Taiwan (NSC 97-2314-B-182A-017-MY2). The funding source had
   no role in the design and conduct of the study; collection, analysis,
   and interpretation of the data; and preparation, review or approval of
   the manuscript.
CR Al-Zoairy R, 2013, CURR DIABETES REV, V9, P362, DOI 10.2174/15733998113099990067
   Albert U, 2013, GEN HOSP PSYCHIAT, V35, P154, DOI 10.1016/j.genhosppsych.2012.10.004
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   [Anonymous], 2000, DIAGN STAT MAN MENT
   Barnes RD., 2011, Prim Care Companion CNS Disord, V13
   Blomquist KK, 2012, COMPR PSYCHIAT, V53, P1021, DOI 10.1016/j.comppsych.2012.02.006
   Butnoriene J, 2014, PSYCHONEUROENDOCRINO, V40, P269, DOI 10.1016/j.psyneuen.2013.11.002
   Carroll D, 2009, BIOL PSYCHIAT, V66, P91, DOI 10.1016/j.biopsych.2009.02.020
   Chadda RK, 2013, J PHARMACOL PHARMACO, V4, P176, DOI 10.4103/0976-500X.114596
   Chang H, 2009, ART NEWS, V108, P124
   Duncan EJ, 2009, INT CLIN PSYCHOPHARM, V24, P204, DOI 10.1097/YIC.0b013e32832d6c18
   First MB., 2002, STRUCTURED CLIN INTE
   Garcia-Portilla MP, 2008, J AFFECT DISORDERS, V106, P197, DOI 10.1016/j.jad.2007.06.002
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   HAMILTON M, 1967, Br J Soc Clin Psychol, V6, P278
   Hasnain M, 2013, POSTGRAD MED, V125, P117, DOI 10.3810/pgm.2013.09.2706
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Hildrum B, 2009, ACTA PSYCHIAT SCAND, V120, P14, DOI 10.1111/j.1600-0447.2008.01315.x
   Hung CI, 2012, INT J PSYCHIAT CLIN, V16, P33, DOI 10.3109/13651501.2011.617456
   Hung CI, 2010, J AFFECT DISORDERS, V125, P134, DOI 10.1016/j.jad.2009.12.010
   Hwang LC, 2006, J FORMOS MED ASSOC, V105, P626, DOI 10.1016/S0929-6646(09)60161-3
   Kahl KG, 2012, EUR ARCH PSY CLIN N, V262, P313, DOI 10.1007/s00406-011-0277-4
   Kim B, 2008, J AFFECT DISORDERS, V105, P45, DOI 10.1016/j.jad.2007.04.006
   Malhotra N, 2013, J AFFECT DISORDERS, V150, P653, DOI 10.1016/j.jad.2013.03.010
   McElroy SL, 2014, J CLIN PSYCHIAT, V75, P46, DOI [10.4088/JCP.13010tx4c, 10.4088/JCP.13r08634]
   McIntyre RS, 2014, J AFFECT DISORDERS, V156, P1, DOI 10.1016/j.jad.2013.10.043
   McIntyre RS, 2009, CURR DIABETES REP, V9, P51, DOI 10.1007/s11892-009-0010-0
   Richter N, 2010, EUR ARCH PSY CLIN N, V260, P41, DOI 10.1007/s00406-009-0013-5
   Singh RB, 2012, CAN J PHYSIOL PHARM, V90, P1171, DOI [10.1139/Y2012-122, 10.1139/y2012-122]
   Stahl SM, 2009, ACTA PSYCHIAT SCAND, V119, P171, DOI 10.1111/j.1600-0447.2008.01334.x
   Takeuchi T, 2013, PSYCHIAT CLIN NEUROS, V67, P532, DOI 10.1111/pcn.12104
   Taylor V, 2006, J CLIN PSYCHIAT, V67, P1034, DOI 10.4088/JCP.v67n0704
   Torrent C, 2008, ACTA PSYCHIAT SCAND, V118, P4, DOI 10.1111/j.1600-0447.2008.01204.x
   van Winkel R, 2008, J CLIN PSYCHIAT, V69, P1319, DOI 10.4088/JCP.v69n0817
   Viinamäki H, 2009, ACTA PSYCHIAT SCAND, V120, P23, DOI 10.1111/j.1600-0447.2008.01333.x
   Wang YB, 2013, CURR PHARM DESIGN, V19, P4799, DOI 10.2174/1381612811319270002
   Wu RR, 2006, PSYCHOPHARMACOLOGY, V186, P572, DOI 10.1007/s00213-006-0384-5
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 38
TC 26
Z9 30
U1 0
U2 16
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD JUN 21
PY 2014
VL 14
AR 185
DI 10.1186/1471-244X-14-185
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AK3HS
UT WOS:000338314700001
PM 24952586
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vaccarino, V
   McClure, C
   Johnson, BD
   Sheps, DS
   Bittner, V
   Rutledge, T
   Shaw, LJ
   Sopko, G
   Olson, MB
   Krantz, DS
   Parashar, S
   Marroqui, OC
   Merz, CNB
AF Vaccarino, Viola
   McClure, Candace
   Johnson, B. Delia
   Sheps, David S.
   Bittner, Vera
   Rutledge, Thomas
   Shaw, Leslee J.
   Sopko, George
   Olson, Marian B.
   Krantz, David S.
   Parashar, Susmita
   Marroqui, Oscar C.
   Merz, C. Noel Bairey
TI Depression, the metabolic syndrome and cardiovascular risk
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE depression; cardiovascular disease; women; metabolic syndrome; obesity
ID SYNDROME EVALUATION WISE; CORONARY-ARTERY-DISEASE; INSULIN-RESISTANCE;
   HEART-DISEASE; YOUNG-ADULTS; WOMEN; MORTALITY; SYMPTOMS; ISCHEMIA;
   HISTORY
AB Background: The relationship between depression and the metabolic syndrome is unclear, and whether metabolic syndrome explains the association between depression and cardiovascular disease (CVD) risk is unknown. Methods: We studied 652 women who received coronary angiography as part of the Women's Ischemia Syndrome Evaluation (WISE) study and completed the Beck Depression Inventory (BDI). Women who had both elevated depressive symptoms (BD1 >= 10) and a previous diagnosis of depression were considered at highest risk, whereas those with one of the two conditions represented an intermediate group. The metabolic syndrome was defined according to the ATP-III criteria. The main outcome was incidence of adverse CVD events (hospitalizations for myocardial infarction, stroke, congestive heart failure, and CVD-related mortality) over a median follow-up of 5.9 years. Results: After adjusting for demographic factors, lifestyle and functional status, both depression categories were associated with about 60% increased odds for metabolic syndrome compared with no depression (p = .03). The number of metabolic syndrome risk factors increased gradually across the three depression categories (p = .003). During follow-up, 104 women (15.9%) experienced CVD events. In multivariable analysis, women with both elevated symptoms and a previous diagnosis of depression had 2.6 times higher risk of CVD. When metabolic syndrome was added to the model, the risk associated with depression only decreased by 7%, and both depression and metabolic syndrome remained significant predictors of CVD. Conclusions: In women with suspected coronary artery disease, the metabolic syndrome is independently associated with depression but explains only a small portion of the association between depression and incident CVD.
C1 [Vaccarino, Viola; Shaw, Leslee J.] Emory Univ, Sch Med, Dept Med, Div Cardiol, Atlanta, GA 30306 USA.
   [Parashar, Susmita] Emory Univ, Sch Med, Dept Med, Div Gen Med, Atlanta, GA USA.
   [McClure, Candace; Johnson, B. Delia; Olson, Marian B.] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA.
   [Marroqui, Oscar C.] Univ Pittsburgh, Med Ctr, Cardiovasc Inst, Pittsburgh, PA USA.
   [Sheps, David S.] Univ Florida, Dept Med, Div Cardiovasc Med, Gainesville, FL USA.
   [Bittner, Vera] Univ Alabama Birmingham, Dept Med, Div Cardiovasc Dis, Birmingham, AL 35294 USA.
   [Rutledge, Thomas] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.
   [Sopko, George] NHLBI, NIH, Bethesda, MD 20892 USA.
   [Krantz, David S.] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA.
   [Merz, C. Noel Bairey] Cedars Sinai Med Ctr, Cedars Sinai Res Inst, Dept Med, Div Cardiol, Los Angeles, CA 90048 USA.
C3 Emory University; Emory University; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh; State University System of Florida; University of Florida;
   University of Alabama System; University of Alabama Birmingham;
   University of California System; University of California San Diego;
   National Institutes of Health (NIH) - USA; NIH National Heart Lung &
   Blood Institute (NHLBI); Uniformed Services University of the Health
   Sciences - USA; Cedars Sinai Medical Center
RP Vaccarino, V (corresponding author), Emory Univ, Sch Med, Dept Med, Div Cardiol, 1256 Briarcliff Rd NE,Suite-1 N, Atlanta, GA 30306 USA.
EM viola.vaccarino@emory.edu
RI Krantz, David/L-5364-2015; Vaccarino, Viola/AAW-5600-2020; Parashar,
   Susmita/GYJ-3885-2022; Marroquin, Oscar/F-2214-2015; Shaw,
   Leslee/ABG-4621-2022
OI Bittner, Vera/0000-0001-9456-850X; Vaccarino, Laura
   Viola/0000-0002-9054-0654; Krantz, David/0000-0002-1671-1355
FU NCRR NIH HHS [M01-RR00425] Funding Source: Medline; NHLBI NIH HHS
   [N01-HV-68161, N01-HV-68162, K24HL077506, N01-HV-68163, N01-HV-68164,
   R01-HL68630] Funding Source: Medline; NIA NIH HHS [R01 AG026255] Funding
   Source: Medline
CR Agatisa PIK, 2005, ARCH INTERN MED, V165, P1229, DOI 10.1001/archinte.165.11.1229
   AHERN DK, 1990, AM J CARDIOL, V66, P59, DOI 10.1016/0002-9149(90)90736-K
   [Anonymous], 1973, Nonparametric statistical methods
   Barth J, 2004, PSYCHOSOM MED, V66, P802, DOI 10.1097/01.psy.0000146332.53619.b2
   Beck A.T., 1987, Beck Fastening
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   Bush TL, 1996, JAMA-J AM MED ASSOC, V276, P1389, DOI 10.1001/jama.276.17.1389
   CARNEY RM, 1987, AM J CARDIOL, V60, P1273, DOI 10.1016/0002-9149(87)90607-2
   Carney RM, 2005, PSYCHOSOM MED, V67, pS29, DOI 10.1097/01.psy.0000162254.61556.d5
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   Everson-Rose SA, 2004, DIABETES CARE, V27, P2856, DOI 10.2337/diacare.27.12.2856
   FRASURESMITH N, 1995, CIRCULATION, V91, P999, DOI 10.1161/01.CIR.91.4.999
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   GLASSMAN AH, 1990, JAMA-J AM MED ASSOC, V264, P1546, DOI 10.1001/jama.264.12.1546
   Glassman AH, 1998, AM J PSYCHIAT, V155, P4, DOI 10.1176/ajp.155.1.4
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hanley AJG, 2002, DIABETES CARE, V25, P1177, DOI 10.2337/diacare.25.7.1177
   Hasin DS, 2005, ARCH GEN PSYCHIAT, V62, P1097, DOI 10.1001/archpsyc.62.10.1097
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   HLATKY MA, 1989, AM J CARDIOL, V64, P651, DOI 10.1016/0002-9149(89)90496-7
   Jones DJ, 2003, ARCH GEN PSYCHIAT, V60, P153, DOI 10.1001/archpsyc.60.2.153
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lett HS, 2004, PSYCHOSOM MED, V66, P305, DOI 10.1097/01.psy.0000126207.43307.c0
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Mallik S, 2006, ARCH INTERN MED, V166, P876, DOI 10.1001/archinte.166.8.876
   McCaffery JM, 2003, PSYCHOSOM MED, V65, P490, DOI 10.1097/01.PSY.0000041545.52924.82
   Merz CNB, 1999, J AM COLL CARDIOL, V33, P1453
   Naqvi TZ, 2005, PSYCHOSOM MED, V67, pS15, DOI 10.1097/01.psy.0000164013.55453.05
   Panagiotakos DB, 2004, EUR HEART J, V25, P492, DOI 10.1016/j.ehj.2004.01.018
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Räikkönen K, 1999, INT J OBESITY, V23, P775, DOI 10.1038/sj.ijo.0800917
   Raison CL, 2006, TRENDS IMMUNOL, V27, P24, DOI 10.1016/j.it.2005.11.006
   Reaven GM, 1996, NEW ENGL J MED, V334, P374, DOI 10.1056/NEJM199602083340607
   Rumsfeld JS, 2005, CIRCULATION, V111, P250, DOI 10.1161/01.CIR.0000154573.62822.89
   Rutledge T, 2006, ARCH GEN PSYCHIAT, V63, P874, DOI 10.1001/archpsyc.63.8.874
   Sharaf BL, 2001, AM J CARDIOL, V87, P937, DOI 10.1016/S0002-9149(01)01424-2
   Wessel TR, 2004, JAMA-J AM MED ASSOC, V292, P1179, DOI 10.1001/jama.292.10.1179
   Wulsin LR, 2003, PSYCHOSOM MED, V65, P201, DOI 10.1097/01.PSY.0000058371.50240.E3
   Ziegelstein RC, 1998, ARCH INTERN MED, V158, P808, DOI 10.1001/archinte.158.7.808
NR 40
TC 137
Z9 154
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JAN
PY 2008
VL 70
IS 1
BP 40
EP 48
DI 10.1097/PSY.0b013e31815c1b85
PG 9
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 253GM
UT WOS:000252506700007
PM 18158378
DA 2025-06-11
ER

PT J
AU Khuwaja, AK
   Lalani, S
   Dhanani, R
   Azam, IS
   Rafique, G
   White, F
AF Khuwaja, Ali Khan
   Lalani, Saima
   Dhanani, Raheem
   Azam, Iqbal Syed
   Rafique, Ghazala
   White, Franklin
TI Anxiety and depression among outpatients with type 2 diabetes: A
   multi-centre study of prevalence and associated factors
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; RISK-FACTORS; COMORBID DEPRESSION;
   DISORDERS; ADULTS; HEALTH; COMPLICATIONS; POPULATION; ADHERENCE
AB Background: Anxiety and depression contribute to poor disease outcomes among individuals with diabetes. This study aimed to assess the prevalence of anxiety and depression and to identify their associated factors including metabolic components among people with type 2 diabetes.
   Methods: We conducted a cross-sectional, multi-center study in four out-patient clinics in Karachi, Pakistan. In all, 889 adults with type-2 diabetes were included in this study. Anxiety and depression were measured by using the Hospital Anxiety and Depression Scale (HADS). Multivariable analysis using multiple logistic regression was carried out to evaluate the combined effect of various factors associated with anxiety and depression, while adjusting for confounding variables.
   Results: Overall, 57.9% (95% CI = 54.7%, 61.2%) and 43.5% (95% CI = 40.3%, 46.8%) study participants had anxiety and depression respectively. Factors found to be independently associated with anxiety were physical inactivity, having hypertension and ischemic heart disease. For depression, being female, of older age, having hypertension and ischemic heart disease were significantly associated. Metabolic components found to be independently associated with both anxiety and depression were systolic blood pressure, fasting blood glucose and fasting blood triglycerides. Body mass index was independently associated with depression but not with anxiety.
   Conclusion: This study identified that a large proportion of adults with diabetes had anxiety and/or depression, and identified factors associated with these entities. These results alert clinicians to identify and treat anxiety and depression as common components of diabetes care. Additional studies are needed to establish the directional nature of this relationship and to test interventions.
C1 [Khuwaja, Ali Khan] Aga Khan Univ, Dept Family Med, Karachi 74880, Pakistan.
   [Lalani, Saima] Aga Khan Univ, Coll Med, Karachi 74880, Pakistan.
   [Dhanani, Raheem] Aga Khan Univ, Dept Family Med, Karachi, Pakistan.
   [Dhanani, Raheem] McGill Univ, Dept Family Med, Montreal, PQ H3A 2T5, Canada.
   [White, Franklin] Pacific Hlth & Dev Sci Inc, Victoria, BC, Canada.
   [White, Franklin] Dalhousie Univ, Halifax, NS, Canada.
C3 Aga Khan University; Aga Khan University; Aga Khan University; McGill
   University; Dalhousie University
RP Khuwaja, AK (corresponding author), Aga Khan Univ, Dept Family Med, Karachi 74880, Pakistan.
EM ali.khuwaja@aku.edu
CR Ali S, 2010, DIABETES-METAB RES, V26, P75, DOI 10.1002/dmrr.1065
   Almawi W, 2008, J ENDOCRINOL INVEST, V31, P1020, DOI 10.1007/BF03345642
   [Anonymous], 2010, District Level Household and Facility Survey 2007-08, P4
   Bouwman V, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009971
   Ciechanowski PS, 2000, ARCH INTERN MED, V160, P3278, DOI 10.1001/archinte.160.21.3278
   Collins MM, 2009, DIABETIC MED, V26, P153, DOI 10.1111/j.1464-5491.2008.02648.x
   Craft LL, 2007, J WOMENS HEALTH, V16, P1499, DOI 10.1089/jwh.2007.0483
   Craft Lynette L., 2004, Prim Care Companion J Clin Psychiatry, V6, P104
   Danese A, 2009, ARCH PEDIAT ADOL MED, V163, P1135, DOI 10.1001/archpediatrics.2009.214
   Dogar Imtiaz Ahmad, 2008, Psychiatry (Edgmont), V5, P38
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   Egede LE, 2002, DIABETES CARE, V25, P464, DOI 10.2337/diacare.25.3.464
   Ganatra HA, 2008, AGING MENT HEALTH, V12, P349, DOI 10.1080/13607860802121068
   Gonzalez JS, 2007, DIABETES CARE, V30, P2222, DOI 10.2337/dc07-0158
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Hildrum B, 2009, ACTA PSYCHIAT SCAND, V120, P14, DOI 10.1111/j.1600-0447.2008.01315.x
   Hong X, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-148
   Iype T, 2009, ANN INDIAN ACAD NEUR, V12, P25, DOI 10.4103/0972-2327.48848
   Katon W, 2010, DEPRESS ANXIETY, V27, P323, DOI 10.1002/da.20683
   Katon W, 2009, PSYCHOSOMATICS, V50, P570, DOI 10.1176/appi.psy.50.6.570
   Khowaja LA, 2007, BMC HEALTH SERV RES, V7, DOI 10.1186/1472-6963-7-189
   Khuwaja A. K., 2004, JPMA Journal of the Pakistan Medical Association, V54, P45
   Khuwaja AK, 2010, CHRONIC ILLN, V6, P163, DOI 10.1177/1742395309352255
   Labad J, 2010, DIABETOLOGIA, V53, P467, DOI 10.1007/s00125-009-1628-9
   Lin EHB, 2009, ANN FAM MED, V7, P414, DOI 10.1370/afm.998
   Lin EHB, 2010, DIABETES CARE, V33, P264, DOI 10.2337/dc09-1068
   Maharaj RG, 2005, W INDIAN MED J, V54, P369
   Mirza I, 2004, BMJ-BRIT MED J, V328, P794, DOI 10.1136/bmj.328.7443.794
   Mosaku K, 2008, J NATL MED ASSOC, V100, P73, DOI 10.1016/S0027-9684(15)31178-0
   Moussavi S, 2007, LANCET, V370, P851, DOI 10.1016/S0140-6736(07)61415-9
   Nichols Lori, 2007, Cost Eff Resour Alloc, V5, P4, DOI 10.1186/1478-7547-5-4
   PADDISON CA, 2010, BR J HLTH PSYCHOL
   Perveen S, 2010, DIABETOL METAB SYNDR, V2, DOI 10.1186/1758-5996-2-17
   Pouwer F, 2009, NAT REV ENDOCRINOL, V5, P665, DOI 10.1038/nrendo.2009.214
   Simon GE, 2007, ARCH GEN PSYCHIAT, V64, P65, DOI 10.1001/archpsyc.64.1.65
   Stein DJ, 2004, LANCET, V364, P233, DOI 10.1016/S0140-6736(04)16693-2
   Takeuchi T, 2009, DIABETES-METAB RES, V25, P762, DOI 10.1002/dmrr.1041
   Thomas J, 2003, DIABETES CARE, V26, P2311, DOI 10.2337/diacare.26.8.2311
   Vogelzangs N, 2007, PSYCHONEUROENDOCRINO, V32, P151, DOI 10.1016/j.psyneuen.2006.11.009
NR 39
TC 170
Z9 191
U1 0
U2 16
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD DEC 20
PY 2010
VL 2
AR 72
DI 10.1186/1758-5996-2-72
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 759RC
UT WOS:000290265000002
PM 21171976
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gans, ROB
AF Gans, Rijk O. B.
TI The metabolic syndrome, depression, and cardiovascular disease:
   Interrelated conditions that share pathophysiologic mechanisms
SO MEDICAL CLINICS OF NORTH AMERICA
LA English
DT Article
ID CORONARY-HEART-DISEASE; INDUCED MYOCARDIAL-ISCHEMIA; AUTONOMIC
   NERVOUS-SYSTEM; INSULIN-RESISTANCE; MENTAL STRESS; BLOOD-PRESSURE;
   RISK-FACTORS; ENDOTHELIAL DYSFUNCTION; CAROTID ATHEROSCLEROSIS;
   PLATELET-FUNCTION
AB This article introduces the metabolic syndrome as a clinical phenotype with consequences for diagnosis and treatment that go beyond the different clinical specialties involved. A life-course approach is suggested as a means of understanding the complex interrelations between the metabolic syndrome, depression, and cardiovascular disease. Pathophysiologic mechanisms that these conditions share are discussed in detail. These considerations provide arguments for a more integrative approach to patients in general that surpass the current disease-centered services such as endocrinology, psychiatry, and cardiology.
C1 Univ Groningen, Med Ctr, NL-9700 RB Groningen, Netherlands.
C3 University of Groningen
RP Gans, ROB (corresponding author), Univ Groningen, Med Ctr, Hanzepl 1, NL-9700 RB Groningen, Netherlands.
EM r.o.b.gans@int.umcg.nl
OI Gans, Reinold/0000-0001-5481-2387
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Alexopoulos GS, 1997, ARCH GEN PSYCHIAT, V54, P915
   Anisman H, 2002, BRAIN BEHAV IMMUN, V16, P513, DOI 10.1016/S0889-1591(02)00009-0
   Badman MK, 2005, SCIENCE, V307, P1909, DOI 10.1126/science.1109951
   Ben-Shlomo Y, 2002, INT J EPIDEMIOL, V31, P285, DOI 10.1093/ije/31.2.285
   Bhatnagar S, 1998, NEUROSCIENCE, V84, P1025, DOI 10.1016/S0306-4522(97)00577-0
   Broadley AJM, 2005, J AM COLL CARDIOL, V46, P344, DOI 10.1016/j.jacc.2005.03.068
   Bruce EC, 2005, PSYCHOSOM MED, V67, pS34, DOI 10.1097/01.psy.0000164227.63647.d9
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   Brunner EJ, 1997, DIABETOLOGIA, V40, P1341, DOI 10.1007/s001250050830
   Bujalska IJ, 1997, LANCET, V349, P1210, DOI 10.1016/S0140-6736(96)11222-8
   Cardillo C, 1998, J AM COLL CARDIOL, V32, P1207, DOI 10.1016/S0735-1097(98)00391-X
   Carnethon MR, 2003, CIRCULATION, V107, P2190, DOI 10.1161/01.CIR.0000066324.74807.95
   Carney RM, 2005, PSYCHOSOM MED, V67, pS29, DOI 10.1097/01.psy.0000162254.61556.d5
   Christakis NA, 2006, NEW ENGL J MED, V354, P719, DOI 10.1056/NEJMsa050196
   Cohen S, 1997, JAMA-J AM MED ASSOC, V277, P1940
   COHEN S, 1991, NEW ENGL J MED, V325, P606, DOI 10.1056/NEJM199108293250903
   Craig AD, 2002, NAT REV NEUROSCI, V3, P655, DOI 10.1038/nrn894
   Dallman MF, 2004, ENDOCRINOLOGY, V145, P2633, DOI 10.1210/en.2004-0037
   Danesh J, 2004, NEW ENGL J MED, V350, P1387, DOI 10.1056/NEJMoa032804
   Despres JP, 1996, NEW ENGL J MED, V334, P952, DOI 10.1056/NEJM199604113341504
   Eaker ED, 2005, PSYCHOSOM MED, V67, P692, DOI 10.1097/01.psy.0000174050.87193.96
   Ebmeier KP, 2006, LANCET, V367, P153, DOI 10.1016/S0140-6736(06)67964-6
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Eisenberger NI, 2003, SCIENCE, V302, P290, DOI 10.1126/science.1089134
   Engum A, 2005, DIABETES CARE, V28, P1904, DOI 10.2337/diacare.28.8.1904
   Eriksson JG, 2001, BRIT MED J, V322, P949, DOI 10.1136/bmj.322.7292.949
   Everson SA, 1997, BRIT MED J, V314, P553, DOI 10.1136/bmj.314.7080.553
   Everson SA, 1996, HYPERTENSION, V27, P1059, DOI 10.1161/01.HYP.27.5.1059
   Everson-Rose SA, 2004, DIABETES CARE, V27, P2856, DOI 10.2337/diacare.27.12.2856
   Festa A, 2000, DIABETES CARE, V23, P624, DOI 10.2337/diacare.23.5.624
   Frankel S, 1996, LANCET, V348, P1478, DOI 10.1016/S0140-6736(96)03482-4
   Fryers Tom, 2005, Clin Pract Epidemiol Ment Health, V1, P14
   Hanley AJG, 2003, DIABETES, V52, P2740, DOI 10.2337/diabetes.52.11.2740
   Hansson GK, 2005, NEW ENGL J MED, V352, P1685, DOI 10.1056/NEJMra043430
   Haslam DW, 2005, LANCET, V366, P1197, DOI 10.1016/S0140-6736(05)67483-1
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   Kamarck TW, 1997, CIRCULATION, V96, P3842
   Kaplan GA, 2006, ANN INTERN MED, V144, P137, DOI 10.7326/0003-4819-144-2-200601170-00012
   Kelley DE, 2000, DIABETES, V49, P677, DOI 10.2337/diabetes.49.5.677
   Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2548, DOI 10.1210/jc.2004-0395
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   KIRMAYER LJ, 1993, AM J PSYCHIAT, V150, P734
   Knowler WC, 2002, NEW ENGL J MED, V346, P393, DOI 10.1056/nejmoa012512
   Kral BG, 1997, CIRCULATION, V96, P4246
   KRANTZ DS, 1991, PSYCHOSOM MED, V53, P1
   Kreier F, 2003, DIABETES, V52, P2652, DOI 10.2337/diabetes.52.11.2652
   Kuh D, 2002, BRIT MED J, V325, P1076, DOI 10.1136/bmj.325.7372.1076
   Lawlor DA, 2003, BRIT MED J, V327, P1383, DOI 10.1136/bmj.327.7428.1383
   Leor J, 1996, NEW ENGL J MED, V334, P413, DOI 10.1056/NEJM199602153340701
   Lindley SE, 1999, NEUROPSYCHOPHARMACOL, V21, P399, DOI 10.1016/S0893-133X(98)00103-1
   Lithell HO, 1996, BMJ-BRIT MED J, V312, P406
   MARKOWE HLJ, 1985, BMJ-BRIT MED J, V291, P1312, DOI 10.1136/bmj.291.6505.1312
   MATTHEWS KA, 1993, HYPERTENSION, V22, P479, DOI 10.1161/01.HYP.22.4.479
   Matthews KA, 1998, STROKE, V29, P1525, DOI 10.1161/01.STR.29.8.1525
   McCabe PM, 2002, CIRCULATION, V105, P354, DOI 10.1161/hc0302.102144
   McElroy SL, 2004, J CLIN PSYCHIAT, V65, P634
   McEwen BS, 1997, ANN NY ACAD SCI, V821, P271, DOI 10.1111/j.1749-6632.1997.tb48286.x
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   Miller GE, 2005, PSYCHOSOM MED, V67, P679, DOI 10.1097/01.psy.0000174172.82428.ce
   Morgan D, 2002, NAT NEUROSCI, V5, P169, DOI 10.1038/nn798
   Okamura F, 2000, METABOLISM, V49, P1255, DOI 10.1053/meta.2000.9515
   Panzer C, 2002, DIABETES, V51, P803, DOI 10.2337/diabetes.51.3.803
   Raikkonen K, 1996, ARTERIOSCL THROM VAS, V16, P363, DOI 10.1161/01.ATV.16.3.363
   Rajagopalan S, 2001, AM J CARDIOL, V88, P196, DOI 10.1016/S0002-9149(01)01623-X
   Ramasubbu R, 2002, MED HYPOTHESES, V59, P537, DOI 10.1016/S0306-9877(02)00244-X
   REES K, 2004, COCHRANE DB SYST REV, V4
   Rosmond R, 2000, OBES RES, V8, P445, DOI 10.1038/oby.2000.55
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Rothman KJ, 2005, AM J PUBLIC HEALTH, V95, pS144, DOI 10.2105/AJPH.2004.059204
   Rozanski A, 2005, PSYCHOSOM MED, V67, pS67, DOI 10.1097/01.psy.0000164252.07368.81
   Rozanski A, 2005, J AM COLL CARDIOL, V45, P637, DOI 10.1016/j.jacc.2004.12.005
   Rugulies R, 2002, AM J PREV MED, V23, P51, DOI 10.1016/S0749-3797(02)00439-7
   Sapolsky RM, 1997, ARCH GEN PSYCHIAT, V54, P1137
   Sapolsky RM, 1996, SCIENCE, V273, P749, DOI 10.1126/science.273.5276.749
   SCHNALL PL, 1990, JAMA-J AM MED ASSOC, V263, P1929, DOI 10.1001/jama.263.14.1929
   Schneider DJ, 2005, CORONARY ARTERY DIS, V16, P473, DOI 10.1097/00019501-200512000-00003
   Selye H, 1936, NATURE, V138, P32, DOI 10.1038/138032a0
   Serné EH, 2001, CARDIOVASC RES, V49, P161, DOI 10.1016/S0008-6363(00)00198-X
   Spieker LE, 2002, CIRCULATION, V105, P2817, DOI 10.1161/01.CIR.0000021598.15895.34
   Suarez EC, 1998, PSYCHOSOM MED, V60, P78, DOI 10.1097/00006842-199801000-00017
   Tataranni P A, 2003, Obes Rev, V4, P229, DOI 10.1046/j.1467-789X.2003.00111.x
   Taylor CB, 2005, ARCH GEN PSYCHIAT, V62, P792, DOI 10.1001/archpsyc.62.7.792
   THEORELL T, 1988, SCAND J WORK ENV HEA, V14, P189, DOI 10.5271/sjweh.1932
   Timonen M, 2005, BMJ-BRIT MED J, V330, P17, DOI 10.1136/bmj.38313.513310.F71
   Tracey KJ, 2002, NATURE, V420, P853, DOI 10.1038/nature01321
   Vita JA, 2004, CIRCULATION, V110, P3604, DOI 10.1161/01.CIR.0000148821.97162.5E
   Vitale C, 2005, J INTERN MED, V258, P250, DOI 10.1111/j.1365-2796.2005.01531.x
   Volkow ND, 2002, SYNAPSE, V44, P175, DOI 10.1002/syn.10075
   Wager TD, 2004, SCIENCE, V303, P1162, DOI 10.1126/science.1093065
   Wang GJ, 2001, LANCET, V357, P354, DOI 10.1016/S0140-6736(00)03643-6
   Watson SL, 1998, ATHEROSCLEROSIS, V137, P259, DOI 10.1016/S0021-9150(97)00277-3
   Weber-Hamann B, 2002, PSYCHOSOM MED, V64, P274, DOI 10.1097/00006842-200203000-00010
   Wiles NJ, 2005, BRIT J PSYCHIAT, V187, P21, DOI 10.1192/bjp.187.1.21
   Wittstein IS, 2005, NEW ENGL J MED, V352, P539, DOI 10.1056/NEJMoa043046
   Yudkin JS, 2005, LANCET, V365, P1817, DOI 10.1016/S0140-6736(05)66585-3
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
NR 97
TC 47
Z9 50
U1 1
U2 5
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0025-7125
EI 1557-9859
J9 MED CLIN N AM
JI Med. Clin. N. Am.
PD JUL
PY 2006
VL 90
IS 4
BP 573
EP +
DI 10.1016/j.mcna.2006.05.002
PG 20
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 071QB
UT WOS:000239615600005
PM 16843763
DA 2025-06-11
ER

PT J
AU Nover, CH
AF Nover, Cynthia Helen
TI Implementing a Mental Health and Primary Care Partnership Program in
   Placer County, California
SO SOCIAL WORK IN HEALTH CARE
LA English
DT Article
DE social support; cognitive behavior intervention; psychosocial
   intervention; primary care; social work; mental health
ID LIFE-STYLE; CARDIOVASCULAR RISK; COLLABORATIVE CARE; METABOLIC SYNDROME;
   LED INTERVENTION; CHRONIC ILLNESS; SCHIZOPHRENIA; DEPRESSION;
   MANAGEMENT; DISORDERS
AB Individuals with serious mental illness are at an increased risk for developing co-morbid chronic physical illnesses, such as diabetes and cardiovascular disease. This article is a descriptive piece about an intervention to decrease physical health risks in this population through a partnership effort between a primary care clinic and mental health agency in rural Placer County, California. The project was conducted as a part of the CalMEND Pilot Collaborative to Integrate Primary Care and Mental Health Services, which took place in five California counties in 2010-2011. A description of the program elements, conceptual models, key measures, and the process of program implementation is provided. Benefits were observed in areas of quality assurance, intra- and inter-agency teamwork, and access to adequate primary care for this population.
C1 Eastern Washington Univ, Sch Social Work, Cheney, WA 99004 USA.
C3 Eastern Washington University
RP Nover, CH (corresponding author), Eastern Washington Univ, Sch Social Work, Senior Hall, Cheney, WA 99004 USA.
EM research.cynthia@gmail.com
CR Bobes J, 2007, SCHIZOPHR RES, V90, P162, DOI 10.1016/j.schres.2006.09.025
   Bobes J, 2010, SCHIZOPHR RES, V119, P101, DOI 10.1016/j.schres.2010.02.1030
   Bodenheimer T, 2002, JAMA-J AM MED ASSOC, V288, P1909, DOI 10.1001/jama.288.15.1909
   Bonnet F, 2005, ATHEROSCLEROSIS, V178, P339, DOI 10.1016/j.atherosclerosis.2004.08.035
   Brunero S, 2009, INT J MENT HEALTH NU, V18, P144, DOI 10.1111/j.1447-0349.2009.00595.x
   Cardenas J, 2008, J AFFECT DISORDERS, V106, P91, DOI 10.1016/j.jad.2007.05.030
   Davis KE, 2011, PSYCHIATR REHABIL J, V34, P317, DOI 10.2975/34.4.2011.317.320
   De Hert M, 2009, EUR PSYCHIAT, V24, P412, DOI 10.1016/j.eurpsy.2009.01.005
   Druss BG, 2010, SCHIZOPHR RES, V118, P264, DOI 10.1016/j.schres.2010.01.026
   Fernández A, 2010, BRIT J PSYCHIAT, V196, P302, DOI 10.1192/bjp.bp.109.074211
   Katon WJ, 2010, NEW ENGL J MED, V363, P2611, DOI 10.1056/NEJMoa1003955
   Kitchen A., 2008, SOCIAL WORK HLTH CAR, V40, P1
   Langely G J., 2009, The Improvement Guide: A Practical Approach to Enhancing Organizational Performance
   Leon AC, 1997, INT J PSYCHIAT MED, V27, P93, DOI 10.2190/T8EM-C8YH-373N-1UWD
   Lucas H., 2005, Primary Health Care Research Development (Sage Publications, V6, P60, DOI [10.1191/1463423605pc210oaS1463423605000083, DOI 10.1191/1463423605PC210OAS1463423605000083]
   McKibbin CL, 2006, SCHIZOPHR RES, V86, P36, DOI 10.1016/j.schres.2006.05.010
   Molarius A, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-302
   Mykletun A, 2010, BMC GASTROENTEROL, V10, DOI 10.1186/1471-230X-10-88
   National Association of State Mental Health Directors (NASMH), 2005, INT BEH HLTH PRIM CA
   Nover CH, 2013, SOC WORK HEALTH CARE, V52, P656, DOI 10.1080/00981389.2013.797537
   Osborn DPJ, 2010, BMC HEALTH SERV RES, V10, DOI 10.1186/1472-6963-10-61
   Pack Steven, 2009, Nurs Stand, V23, P41
   Piippo J, 2004, J CLIN NURS, V13, P876, DOI 10.1111/j.1365-2702.2004.00958.x
   Pohle K, 2009, PSYCHOTHER PSYCHOSOM, V78, P359, DOI 10.1159/000235975
   Rees G, 2004, HEALTH SOC CARE COMM, V12, P527, DOI 10.1111/j.1365-2524.2004.00523.x
   Roberts L, 2007, FAM PRACT, V24, P34, DOI 10.1093/fampra/cml054
   Seekles W, 2009, BMC HEALTH SERV RES, V9, DOI 10.1186/1472-6963-9-90
   Soundy A., 2007, J MENT HEALTH, V16, P493, DOI 10.1080/09638230701482345
   Unützer J, 2002, JAMA-J AM MED ASSOC, V288, P2836, DOI 10.1001/jama.288.22.2836
   Van Orden M, 2009, PSYCHIAT SERV, V60, P74, DOI 10.1176/ps.2009.60.1.74
   Wagner EH, 2001, HEALTH AFFAIR, V20, P64, DOI 10.1377/hlthaff.20.6.64
NR 31
TC 3
Z9 5
U1 0
U2 10
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0098-1389
EI 1541-034X
J9 SOC WORK HEALTH CARE
JI Soc. Work Health Care
PD FEB 7
PY 2014
VL 53
IS 2
BP 156
EP 182
DI 10.1080/00981389.2013.864378
PG 27
WC Social Work
WE Social Science Citation Index (SSCI)
SC Social Work
GA AC0PK
UT WOS:000332197000005
PM 24483334
DA 2025-06-11
ER

PT J
AU Wilson, CE
   Carpenter, JS
   Song, Y
   Ho, N
   Hickie, IB
AF Wilson, Chloe E.
   Carpenter, Joanne S.
   Song, Yun
   Ho, Nicholas
   Hickie, Ian B.
TI Associations between 24-h sleep-wake patterns and cardiometabolic risk
   factors in youth seeking mental health care
SO SLEEP AND BIOLOGICAL RHYTHMS
LA English
DT Article
DE Youth mental ill-health; Cardiometabolic risk factors; Sleep&#8211; wake
   patterns; Actigraphy; Psychopathology
AB One hundred and eleven youth with mental ill-health underwent systematic clinical, laboratory and actigraphy monitoring to report associations between 24-h sleep-wake patterns and cardiometabolic risk factors. Multiple linear regression analyses, controlling for medication usage and class, age and sex, found significant associations between: later sleep onset and BMI; standard variation (SV) in the sleep offset with both insulin values and the updated homeostatic model assessment of insulin resistance (HOMA2-IR) values; and the SV of the sleep midpoint with both poorer fasting insulin, and HOMA2-IR values. Further longitudinal research is required to determine the causative relationships between 24-h sleep-wake cycle patterns, and cardiometabolic outcomes.
C1 [Wilson, Chloe E.; Carpenter, Joanne S.; Song, Yun; Ho, Nicholas; Hickie, Ian B.] Univ Sydney, Brain & Mind Ctr, Youth Mental Hlth Team, Sydney, NSW, Australia.
C3 University of Sydney
RP Wilson, CE (corresponding author), Univ Sydney, Brain & Mind Ctr, Youth Mental Hlth Team, Sydney, NSW, Australia.
EM chloe.wilson@sydney.edu.au
RI Carpenter, Joanne/HZK-3629-2023; Hickie, Ian/K-8975-2015
OI Hickie, Ian/0000-0001-8832-9895; Ho, Nicholas/0000-0001-9843-0866
FU National Health and Medical Research Council Australia Fellowship
   [511921]; Liu McCabe Family Scholarship; Caroline Quinn Research Grant
FX This study was partially funded by a philanthropic gift (The Liu McCabe
   Family Scholarship awarded to C.E.W), a National Health and Medical
   Research Council Australia Fellowship (No. 511921, awarded to I.B.H) and
   a philanthropic gift (the Caroline Quinn Research Grant awarded to
   J.S.C). The funders of this study had no involvement in the: study
   design; collection, analysis and reporting of the data; writing of the
   report; or decision to submit the paper for publication.
CR Feliciano EMC, 2018, PEDIATRICS, V142, DOI 10.1542/peds.2017-4085
   Firth J., 2019, LANCET PSYCHIAT, V10, P19
   Grandner MA, 2012, J SLEEP RES, V21, P427, DOI 10.1111/j.1365-2869.2011.00990.x
   Pillay J., 2017, First-and second-generation antipsychotics in children and young adults: systematic review update
   Roberts LW, 2017, ACAD PSYCHIATR, V41, P441, DOI 10.1007/s40596-017-0738-9
   Robillard R, 2018, TRANSL PSYCHIAT, V8, DOI 10.1038/s41398-018-0255-y
   Scott EM, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-025674
   Tubbs AS, 2020, CURR OPIN PSYCHOL, V34, P84, DOI 10.1016/j.copsyc.2019.11.003
   Vancampfort D, 2017, WORLD PSYCHIATRY, V16, P308, DOI 10.1002/wps.20458
   Wilson C, 2019, CURR SLEEP MED REP, V5, P118, DOI 10.1007/s40675-019-00145-y
NR 10
TC 1
Z9 1
U1 0
U2 0
PU SPRINGER JAPAN KK
PI TOKYO
PA SHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO, 105-6005,
   JAPAN
SN 1446-9235
EI 1479-8425
J9 SLEEP BIOL RHYTHMS
JI Sleep Biol. Rhythms
PD JUL
PY 2021
VL 19
IS 3
BP 337
EP 340
DI 10.1007/s41105-021-00314-z
EA FEB 2021
PG 4
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA SW4NN
UT WOS:000617812800001
DA 2025-06-11
ER

PT J
AU Camacho, A
AF Camacho, Alvaro
TI Is anxious-depression an inflammatory state?
SO MEDICAL HYPOTHESES
LA English
DT Article
ID CORONARY-HEART-DISEASE; CORTICOTROPIN-RELEASING-FACTOR;
   CARDIOVASCULAR-DISEASE; MAJOR DEPRESSION; PLASMINOGEN-ACTIVATOR;
   MYOCARDIAL-INFARCTION; POSTMENOPAUSAL WOMEN; METABOLIC SYNDROME; ANXIETY
   SYMPTOMS; RISK-FACTORS
AB For several years, the literature has examined the association of depression and anxiety with inflammatory states such as atherosclerosis and cardiovascular disease, yet this association remains inconclusive. Several possible immune and endocrinological pathways have been postulated that associate depression and anxiety with inflammation and immune dysregulation. Anxiety and depression have usually been envisioned as two separate psychiatric conditions yet they share similar symptoms and are frequently encountered together among individuals. Individuals suffering from anxious-depression are more refractory to treatment and have been reported to have greater disability compared to individuals with anxiety or depression alone. With the current changes in the diagnostic manual for psychiatric disorders placing more emphasis on a dimensional approach for the diagnosis of psychiatric illnesses, the hypothesis presented is that anxious-depression should be considered as a chronic inflammatory phenomenon since it shares common physiopathological pathways and pharmacological treatments with inflammatory states. This hypothesis might help to investigate how different levels of inflammatory biomarkers could be correlated with symptoms of anxious-depression. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Camacho, Alvaro] Univ Calif San Diego, Dept Family & Prevent Med, San Diego, CA 92251 USA.
   [Camacho, Alvaro] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92251 USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego
RP Camacho, A (corresponding author), Univ Calif San Diego, Dept Family & Prevent Med, 2417 Marshall Ave Ste 1, San Diego, CA 92251 USA.
EM acamacho@ucsd.edu
FU National Heart Lung and Blood Institute, National Institute of Health,
   United States of America [T32HL079891]
FX The author has special gratitude to Joel E. Dimsdale, MD for his years
   of mentorship and support for this manuscript. Also special thanks to
   Matthew A. Allison, MD, MPH and Murray Stein, MD, MPH for their valuable
   feedback. This work was supported by training grant T32HL079891 from the
   National Heart Lung and Blood Institute, National Institute of Health,
   United States of America.
CR Aldhahi Waleed, 2003, Curr Diab Rep, V3, P293, DOI 10.1007/s11892-003-0020-2
   Almond M., 2013, CURRENT PSYCHIAT, V12, P25
   Angst J, 1997, J CLIN PSYCHIAT, V58, P6
   [Anonymous], 2012, Psychiatric News
   [Anonymous], MOL PSYCHIAT
   [Anonymous], COCHRANE DATABASE SY, DOI DOI 10.1007/S00296-012-2619-6
   [Anonymous], COCHRANE DATABASE SY
   Arborelius L, 1999, J ENDOCRINOL, V160, P1, DOI 10.1677/joe.0.1600001
   BARRETT JE, 1988, ARCH GEN PSYCHIAT, V45, P1100
   Bayramgurler D, 2013, PHYSL BEHAV
   Bjelland I, 2002, J PSYCHOSOM RES, V52, P69, DOI 10.1016/S0022-3999(01)00296-3
   Bjelland I, 2009, INT J METH PSYCH RES, V18, P128, DOI 10.1002/mpr.284
   Bot M, 2011, J PSYCHOSOM RES, V71, P13, DOI 10.1016/j.jpsychores.2010.11.006
   Brietzke E, 2012, MED HYPOTHESES, V78, P601, DOI 10.1016/j.mehy.2012.01.036
   Camacho A, 2012, INT SOC CNS CLIN TRI
   Cameron Oliver G, 2006, Essent Psychopharmacol, V7, P24
   Capuron L, 2008, BIOL PSYCHIAT, V64, P896, DOI 10.1016/j.biopsych.2008.05.019
   CHROUSOS GP, 1995, NEW ENGL J MED, V332, P1351, DOI 10.1056/NEJM199505183322008
   Dimsdale JE, 2010, J AM COLL CARDIOL, V56, P47, DOI 10.1016/j.jacc.2010.04.013
   Dortland AKBV, 2013, PSYCHOSOM MED, V75, P83, DOI 10.1097/PSY.0b013e318274d30f
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Elenkov IJ, 2002, ANN NY ACAD SCI, V966, P290, DOI 10.1111/j.1749-6632.2002.tb04229.x
   Elovainio M, 2011, J AFFECT DISORDERS, V133, P611, DOI 10.1016/j.jad.2011.04.025
   Frasure-Smith N, 2008, ARCH GEN PSYCHIAT, V65, P62, DOI 10.1001/archgenpsychiatry.2007.4
   FRASURESMITH N, 1995, HEALTH PSYCHOL, V14, P388, DOI 10.1037/0278-6133.14.5.388
   Goldberg DP, 2012, GEN HOSP PSYCHIAT, V34, P665, DOI 10.1016/j.genhosppsych.2012.06.006
   Goldberg DP, 2010, EVOLUTION DSM 5 CONC
   Grazier KL, 2003, PSYCHIAT SERV, V54, P1508, DOI 10.1176/appi.ps.54.11.1508
   Grippo AJ, 2009, STRESS, V12, P1, DOI 10.1080/10253890802046281
   Haroon E, 2012, NEUROPSYCHOPHARMACOL, V37, P137, DOI 10.1038/npp.2011.205
   Hou SJ, 2009, MED HYPOTHESES, V72, P166, DOI 10.1016/j.mehy.2008.09.009
   Ionescu DF, 2013, CNS SPECTRUMS, P1
   Janszky I, 2010, J AM COLL CARDIOL, V56, P31, DOI 10.1016/j.jacc.2010.03.033
   Judd LL, 2002, PSYCHIAT CLIN N AM, V25, P685, DOI 10.1016/S0193-953X(02)00026-6
   KAPLAN GA, 1995, PSYCHOSOM MED, V57, P208, DOI 10.1097/00006842-199505000-00002
   KATON W, 1991, J ABNORM PSYCHOL, V100, P337, DOI 10.1037/0021-843X.100.3.337
   Kopp S, 1998, J ORAL MAXIL SURG, V56, P189, DOI 10.1016/S0278-2391(98)90867-9
   Kraemer HC, 2012, AM J PSYCHIAT, V169, P13, DOI 10.1176/appi.ajp.2011.11010050
   Kubera N, 2001, J CLIN PSYCHOPHARM, V21, P199, DOI 10.1097/00004714-200104000-00012
   Le-Niculescu H, 2011, TRANSL PSYCHIAT, P1
   Littrell JL, 2012, FRONT PSYCHOL, V3, DOI 10.3389/fpsyg.2012.00297
   Llabre MM, 2012, PSYCHOSOM MED, V74, P169, DOI 10.1097/PSY.0b013e3182433a30
   Lopresti AL., 2013, PROG NEUROPSYCHOPHAR
   Maes M, 1999, NEUROPSYCHOPHARMACOL, V20, P370, DOI 10.1016/S0893-133X(98)00088-8
   Maes M, 2002, LIFE SCI, V71, P1837, DOI 10.1016/S0024-3205(02)01853-2
   Maes M, 1998, CYTOKINE, V10, P313, DOI 10.1006/cyto.1997.0290
   Muldoon MF, 2007, STROKE, V38, P2228, DOI 10.1161/STROKEAHA.106.477638
   Musselman DL, 1998, ARCH GEN PSYCHIAT, V55, P580, DOI 10.1001/archpsyc.55.7.580
   Pan A, 2011, JAMA-J AM MED ASSOC, V306, P1241, DOI 10.1001/jama.2011.1282
   Pan A, 2011, ARCH GEN PSYCHIAT, V68, P42, DOI 10.1001/archgenpsychiatry.2010.176
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Raison CL, 2013, JAMA PSYCHIAT, V70, P31, DOI 10.1001/2013.jamapsychiatry.4
   Roesch SC, 2010, SOC SCI MED, V71, P494, DOI 10.1016/j.socscimed.2010.04.032
   Roesch SC, 2010, CHILD ABUSE NEGLECT, V34, P155, DOI 10.1016/j.chiabu.2010.01.003
   Roest AM, 2010, J AM COLL CARDIOL, V56, P38, DOI 10.1016/j.jacc.2010.03.034
   Rosengren A, 2004, LANCET, V364, P953, DOI 10.1016/S0140-6736(04)17019-0
   Rozanski A, 1999, CIRCULATION, V99, P2192, DOI 10.1161/01.CIR.99.16.2192
   Salazar A, 2012, HORM BEHAV, V62, P202, DOI 10.1016/j.yhbeh.2012.03.010
   Schafer M, 1997, EUR J PHARMACOL, V323, P1, DOI 10.1016/S0014-2999(97)00057-5
   Simon G E, 1995, Arch Fam Med, V4, P99, DOI 10.1001/archfami.4.2.99
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Smith PJ, 2011, REV ESP CARDIOL, V64, P924, DOI 10.1016/j.recesp.2011.06.003
   Smoller JW, 2007, ARCH GEN PSYCHIAT, V64, P1153, DOI 10.1001/archpsyc.64.10.1153
   Suls J, 2005, PSYCHOL BULL, V131, P260, DOI 10.1037/0033-2909.131.2.260
   Teyssier JR, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0049677
   Tsai SJ, 2006, MED HYPOTHESES, V66, P319, DOI 10.1016/j.mehy.2005.10.009
   Vaccarino V, 2007, J AM COLL CARDIOL, V50, P2044, DOI 10.1016/j.jacc.2007.07.069
   Vahia IV, 2010, AM J GERIAT PSYCHIAT, V18, P212, DOI 10.1097/JGP.0b013e3181b7f10e
   van den Biggelaar AHJ, 2007, EXP GERONTOL, V42, P693, DOI 10.1016/j.exger.2007.01.011
   von Känel R, 2012, SWISS MED WKLY, V142, DOI 10.4414/smw.2012.13502
   Vreeburg SA, 2010, PSYCHOSOM MED, V72, P340, DOI 10.1097/PSY.0b013e3181d2f0c8
   Wakefield J, 2011, CURR MED RES OPIN, P1
   Wassertheil-Smoller S, 2004, ARCH INTERN MED, V164, P289, DOI 10.1001/archinte.164.3.289
   Whooley MA, 2007, BIOL PSYCHIAT, V62, P314, DOI 10.1016/j.biopsych.2006.10.016
   Zhang K, 2013, BRAIN RES, P1490
NR 75
TC 34
Z9 37
U1 0
U2 6
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD OCT
PY 2013
VL 81
IS 4
BP 577
EP 581
DI 10.1016/j.mehy.2013.07.006
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 243ZO
UT WOS:000326357100015
PM 23891039
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Song, J
   Kwon, N
   Lee, MH
   Ko, YG
   Lee, JH
   Kim, OY
AF Song, Juhyun
   Kwon, Nayeon
   Lee, Mi-Hyang
   Ko, Young-Guk
   Lee, Jong Ho
   Kim, Oh Yoen
TI Association of serum phospholipid PUFAs with cardiometabolic risk:
   Beneficial effect of DHA on the suppression of vascular
   proliferation/inflammation
SO CLINICAL BIOCHEMISTRY
LA English
DT Article
DE Cardiometabolic risk; Polyunsaturated fatty acids; Docosahexaenoic acid;
   Vascular proliferation; MAPK pathways; Nuclear factor-kappa B p65
   nuclear translocation
ID FATTY-ACID-COMPOSITION; SMOOTH-MUSCLE-CELLS; MIDDLE-AGED MEN;
   DOCOSAHEXAENOIC ACID; DIETARY-FAT; CARDIOVASCULAR MORTALITY; PLASMA;
   P38; MACROPHAGES; INDUCTION
AB Objectives: Blood or dietary polyunsaturated fatty acids (PUFAs), particularly omega 3-PUFAs were known for cardiovascular protective effect. However, the results are still controversial. We aimed to investigate the association of serum phospholipid PUFAs with cardiometabolic risk through cross-sectional/experimental studies.
   Design/methods: Serum phospholipid FA compositions and cardiometabolic risk parameters were measured in controls [healthy: n = 987, metabolic syndrome (MetS): n = 214] and CAD patients (CAD-only: n = 152, CAD + MetS: n = 56). Experimental assays were performed in vascular smooth muscle cells (VSMCs).
   Results: Major cardiometabolic risk markers, i.e. insulin resistance, hs-C-reactive proteins, and malondialdehyde were higher, and adiponectin and LDL particle size were lower in CAD patients, particularly those with MetS than in healthy controls. Serum linoleic acid (LA, C18: 2 omega-6) was lowest and dihomo-gamma-linolenic acids (DGLAs, C20: 3 omega-6) were highest in CAD patients with MetS among the 4 groups. Docosahexaenoic acid (DHA, C22: 6 omega-3) was lower and arachidonic acid (AA, C20: 4 omega-6) and omega 6/omega 3-PUFAs were higher in CAD patients than in controls. omega 3-PUFAs were significantly lower in CAD patients, particularly those with MetS than in healthy controls. Multiple regression analysis revealed that AA and DHA among serum FAs were mainly associated with the cardiometabolic risk (beta'-coefficients for AA:0.336; DHA: -0.296) together with age, MetS factors, LA, DGLA and gender (r = 0.529, p < 0.001). Under LPS-induced stress condition, LA and DHA significantly suppressed VSMC proliferation. DHA also up-regulated the phosphorylation of p38 and ERK, and dramatically inhibited nuclear translocation of NF-kappa B-p65 in VSMCs.
   Conclusion: AA and DHA were mainly associated with cardiometabolic risk. Particularly, DHA may be effective on suppression of vascular proliferation and inflammation. (C) 2014 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
C1 [Song, Juhyun] Yonsei Univ, Interdisciplinary Course Sci Aging, Seoul 120749, South Korea.
   [Kwon, Nayeon; Lee, Mi-Hyang; Lee, Jong Ho] Yonsei Univ, Dept Food & Nutr, Seoul 120749, South Korea.
   [Ko, Young-Guk] Yonsei Univ Hlth Syst, Severance Cardiovasc Hosp, Div Cardiol, Seoul, South Korea.
   [Kim, Oh Yoen] Dong A Univ, Dept Food Sci & Nutr, Pusan 604020, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University; Yonsei
   University Health System; Dong A University
RP Lee, JH (corresponding author), Yonsei Univ, Dept Food & Nutr, Seoul 120749, South Korea.
EM jhleeb@yonsei.ac.kr; oykim@dau.ac.kr
RI Kim, Oh/AAA-6492-2022; Song, Juhyun/AAH-3162-2020
OI Ko, Young-Guk/0000-0001-7748-5788; Song, Juhyun/0000-0002-9165-8507
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF); Ministry of Science, ICT and Future Planning
   [2013R1A1A3011535]; Brain Busan 21 project
FX We thank the research volunteers who participated in the studies
   described in this manuscript. This study was supported by Basic Science
   Research Program through the National Research Foundation of Korea (NRF)
   funded by the Ministry of Science, ICT and Future Planning
   (2013R1A1A3011535) and Brain Busan 21 project.
CR Akbar M, 2005, P NATL ACAD SCI USA, V102, P10858, DOI 10.1073/pnas.0502903102
   American DA, 2010, DIABETES CARE S1, V33, pS11, DOI [DOI 10.2337/dc10-S011, 10.2337/dc10-S011, DOI 10.2337/DC10-S011]
   [Anonymous], 2000, ASIA PACIFIC PERSPEC
   BRUCKNER G, 1987, ATHEROSCLEROSIS, V66, P237, DOI 10.1016/0021-9150(87)90067-0
   Crnkovic S, 2012, FREE RADICAL BIO MED, V52, P1786, DOI 10.1016/j.freeradbiomed.2012.02.036
   Czernichow S, 2010, BRIT J NUTR, V104, P788, DOI 10.1017/S0007114510002096
   Delbosc S, 2008, AM J PATHOL, V172, P1430, DOI 10.2353/ajpath.2008.070951
   Diep QN, 2000, HYPERTENSION, V36, P851, DOI 10.1161/01.HYP.36.5.851
   DOUGHERTY RM, 1987, AM J CLIN NUTR, V45, P443, DOI 10.1093/ajcn/45.2.443
   Feng GM, 2012, EUR J NUTR, V51, P987, DOI 10.1007/s00394-011-0278-0
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Halade GV, 2010, J IMMUNOL, V184, P5280, DOI 10.4049/jimmunol.0903282
   Hayden MS, 2006, ONCOGENE, V25, P6758, DOI 10.1038/sj.onc.1209943
   Hooper L, 2006, BMJ-BRIT MED J, V332, P752, DOI 10.1136/bmj.38755.366331.2F
   Kim Min Ju, 2010, Preventive Nutrition and Food Science, V15, P137
   Kim OY, 2013, NUTR METAB CARDIOVAS, V23, P366, DOI 10.1016/j.numecd.2011.06.006
   Kim YJ, 2012, ATHEROSCLEROSIS, V225, P418, DOI 10.1016/j.atherosclerosis.2012.09.007
   Komatsu W, 2003, FREE RADICAL BIO MED, V34, P1006, DOI 10.1016/S0891-5849(03)00027-3
   Laaksonen DE, 2005, ARCH INTERN MED, V165, P193, DOI 10.1001/archinte.165.2.193
   Leeson CPM, 2002, EUR HEART J, V23, P216, DOI 10.1053/euhj.2001.2728
   MA J, 1995, AM J CLIN NUTR, V62, P564, DOI 10.1093/ajcn/62.3.564
   Machida T, 2005, J PHARMACOL SCI, V99, P113, DOI 10.1254/jphs.SC0050099
   Miles EA, 2004, PROSTAG LEUKOTR ESS, V70, P529, DOI 10.1016/j.plefa.2003.11.008
   Mori TA, 1999, HYPERTENSION, V34, P253, DOI 10.1161/01.HYP.34.2.253
   Mozaffarian D, 2011, J AM COLL CARDIOL, V58, P2047, DOI 10.1016/j.jacc.2011.06.063
   Mozaffarian D, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000252
   Mullen A, 2010, J NUTR BIOCHEM, V21, P444, DOI 10.1016/j.jnutbio.2009.02.008
   Oeckinghaus A, 2009, CSH PERSPECT BIOL, V1, DOI 10.1101/cshperspect.a000034
   Pakala R, 1999, ARTERIOSCL THROM VAS, V19, P2316, DOI 10.1161/01.ATV.19.10.2316
   Petersson H, 2008, BRIT J NUTR, V99, P1186, DOI 10.1017/S0007114507871674
   Roux PP, 2004, MICROBIOL MOL BIOL R, V68, P320, DOI 10.1128/MMBR.68.2.320-344.2004
   Shim JeeSeon Shim JeeSeon, 2002, Korean Journal of Community Nutrition, V7, P484
   Summers LKM, 2002, DIABETOLOGIA, V45, P369, DOI 10.1007/s00125-001-0768-3
   Theobald HE, 2007, J NUTR, V137, P973, DOI 10.1093/jn/137.4.973
   TSUDA K, 1988, CLIN SCI, V75, P477, DOI 10.1042/cs0750477
   Vessby B, 2000, BRIT J NUTR, V83, pS91
   Vessby B, 2003, CURR OPIN LIPIDOL, V14, P15, DOI 10.1097/00041433-200302000-00004
   Warensjö E, 2006, NUTR METAB CARDIOVAS, V16, P128, DOI 10.1016/j.numecd.2005.06.001
   Warensjö E, 2008, AM J CLIN NUTR, V88, P203, DOI 10.1093/ajcn/88.1.203
   Weldon SM, 2007, J NUTR BIOCHEM, V18, P250, DOI 10.1016/j.jnutbio.2006.04.003
NR 41
TC 15
Z9 16
U1 0
U2 14
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
EI 1873-2933
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD APR
PY 2014
VL 47
IS 6
BP 361
EP 368
DI 10.1016/j.clinbiochem.2014.01.005
PG 8
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA AE1WP
UT WOS:000333763300008
PM 24457065
DA 2025-06-11
ER

PT J
AU Fountoulakis, KN
   Karakatsoulis, GN
   Abraham, S
   Adorjan, K
   Ahmed, HU
   Alarcón, RD
   Arai, K
   Auwal, SS
   Berk, M
   Bjedov, S
   Bobes, J
   Bobes-Bascaran, T
   Bourgin-Duchesnay, J
   Bredicean, CA
   Bukelskis, L
   Burkadze, A
   Abud, IIC
   Castilla-Puentes, R
   Cetkovich, M
   Colon-Rivera, H
   Corral, R
   Cortez-Vergara, C
   Crepin, P
   De Berardis, D
   Delgado, SZ
   De Lucena, D
   De Sousa, A
   Di Stefano, R
   Dodd, S
   Elek, LP
   Elissa, A
   Erdelyi-Hamza, B
   Erzin, G
   Etchevers, MJ
   Falkai, P
   Farcas, A
   Fedotov, I
   Filatova, V
   Fountoulakis, NK
   Frankova, I
   Franza, F
   Frias, P
   Galako, T
   Garay, CJ
   Garcia-Alvarez, L
   García-Portilla, MP
   Gonda, X
   Gondek, TM
   González, DM
   Gould, H
   Grandinetti, P
   Grau, A
   Groudeva, V
   Hagin, M
   Harada, T
   Hasan, TM
   Hashim, NA
   Hilbig, J
   Hossain, S
   Iakimova, R
   Ibrahim, M
   Iftene, F
   Ignatenko, Y
   Irarrazaval, M
   Ismail, Z
   Ismayilova, J
   Jakobs, A
   Jakovljevic, M
   Jaksic, N
   Javed, A
   Kafali, HY
   Karia, S
   Kazakova, O
   Khalifa, D
   Khaustova, O
   Koh, S
   Kopishinskaia, S
   Kosenko, K
   Koupidis, SA
   Kovacs, I
   Kulig, B
   Lalljee, A
   Liewig, J
   Majid, A
   Malashonkova, E
   Malik, K
   Malik, NI
   Mammadzada, G
   Mandalia, B
   Marazziti, D
   Marcinko, D
   Martinez, S
   Matiekus, E
   Mejia, G
   Memon, RS
   Martínez, XEM
   Mickeviciute, D
   Milev, R
   Mohammed, M
   Molina-López, A
   Morozov, P
   Muhammad, NS
   Mustac, F
   Naor, MS
   Nassieb, A
   Navickas, A
   Okasha, T
   Pandova, M
   Panfil, AL
   Panteleeva, L
   Papava, I
   Patsali, ME
   Pavlichenko, A
   Pejuskovic, B
   Pinto da Costa, M
   Popkov, M
   Popovic, D
   Raduan, NJN
   Ramírez, FV
   Rancans, E
   Razali, S
   Rebok, F
   Rewekant, A
   Flores, ENR
   Rivera-Encinas, MT
   Saiz, P
   de Carmona, MS
   Martínez, DS
   Saw, JA
   Saygili, G
   Schneidereit, P
   Shah, B
   Shirasaka, T
   Silagadze, K
   Sitanggang, S
   Skugarevsky, O
   Spikina, A
   Mahalingappa, SS
   Stoyanova, M
   Szczegielniak, A
   Tamasan, SC
   Tavormina, G
   Tavormina, MGM
   Theodorakis, PN
   Tohen, M
   Tsapakis, EM
   Tukhvatullina, D
   Ullah, I
   Vaidya, R
   Vega-Dienstmaier, JM
   Vrublevska, J
   Vukovic, O
   Vysotska, O
   Widiasih, N
   Yashikhina, A
   Prezerakos, PE
   Smirnova, D
AF Fountoulakis, Konstantinos N.
   Karakatsoulis, Grigorios N.
   Abraham, Seri
   Adorjan, Kristina
   Ahmed, Helal Uddin
   Alarcon, Renato D.
   Arai, Kiyomi
   Auwal, Sani Salihu
   Berk, Michael
   Bjedov, Sarah
   Bobes, Julio
   Bobes-Bascaran, Teresa
   Bourgin-Duchesnay, Julie
   Bredicean, Cristina Ana
   Bukelskis, Laurynas
   Burkadze, Akaki
   Cabrera Abud, Indira Indiana
   Castilla-Puentes, Ruby
   Cetkovich, Marcelo
   Colon-Rivera, Hector
   Corral, Ricardo
   Cortez-Vergara, Carla
   Crepin, Piirika
   De Berardis, Domenico
   Zamora Delgado, Sergio
   De Lucena, David
   De Sousa, Avinash
   Di Stefano, Ramona
   Dodd, Seetal
   Elek, Livia Priyanka
   Elissa, Anna
   Erdelyi-Hamza, Berta
   Erzin, Gamze
   Etchevers, Martin J.
   Falkai, Peter
   Farcas, Adriana
   Fedotov, Ilya
   Filatova, Viktoriia
   Fountoulakis, Nikolaos K.
   Frankova, Iryna
   Franza, Francesco
   Frias, Pedro
   Galako, Tatiana
   Garay, Cristian J.
   Garcia-Alvarez, Leticia
   Paz Garcia-Portilla, Maria
   Gonda, Xenia
   Gondek, Tomasz M.
   Morera Gonzalez, Daniela
   Gould, Hilary
   Grandinetti, Paolo
   Grau, Arturo
   Groudeva, Violeta
   Hagin, Michal
   Harada, Takayuki
   Hasan, Tasdik M.
   Hashim, Nurul Azreen
   Hilbig, Jan
   Hossain, Sahadat
   Iakimova, Rossitza
   Ibrahim, Mona
   Iftene, Felicia
   Ignatenko, Yulia
   Irarrazaval, Matias
   Ismail, Zaliha
   Ismayilova, Jamila
   Jakobs, Asaf
   Jakovljevic, Miro
   Jaksic, Nenad
   Javed, Afzal
   Kafali, Helin Yilmaz
   Karia, Sagar
   Kazakova, Olga
   Khalifa, Doaa
   Khaustova, Olena
   Koh, Steve
   Kopishinskaia, Svetlana
   Kosenko, Korneliia
   Koupidis, Sotirios A.
   Kovacs, Illes
   Kulig, Barbara
   Lalljee, Alisha
   Liewig, Justine
   Majid, Abdul
   Malashonkova, Evgeniia
   Malik, Khamelia
   Malik, Najma Iqbal
   Mammadzada, Gulay
   Mandalia, Bilvesh
   Marazziti, Donatella
   Marcinko, Darko
   Martinez, Stephanie
   Matiekus, Eimantas
   Mejia, Gabriela
   Memon, Roha Saeed
   Meza Martinez, Xarah Elenne
   Mickeviciute, Dalia
   Milev, Roumen
   Mohammed, Muftau
   Molina-Lopez, Alejandro
   Morozov, Petr
   Muhammad, Nuru Suleiman
   Mustac, Filip
   Naor, Mika S.
   Nassieb, Amira
   Navickas, Alvydas
   Okasha, Tarek
   Pandova, Milena
   Panfil, Anca-Livia
   Panteleeva, Liliya
   Papava, Ion
   Patsali, Mikaella E.
   Pavlichenko, Alexey
   Pejuskovic, Bojana
   Pinto da Costa, Mariana
   Popkov, Mikhail
   Popovic, Dina
   Raduan, Nor Jannah Nasution
   Vargas Ramirez, Francisca
   Rancans, Elmars
   Razali, Salmi
   Rebok, Federico
   Rewekant, Anna
   Reyes Flores, Elena Ninoska
   Teresa Rivera-Encinas, Maria
   Saiz, Pilar
   Sanchez de Carmona, Manuel
   Saucedo Martinez, David
   Saw, Jo Anne
   Saygili, Gorkem
   Schneidereit, Patricia
   Shah, Bhumika
   Shirasaka, Tomohiro
   Silagadze, Ketevan
   Sitanggang, Satti
   Skugarevsky, Oleg
   Spikina, Anna
   Mahalingappa, Sridevi Sira
   Stoyanova, Maria
   Szczegielniak, Anna
   Tamasan, Simona Claudia
   Tavormina, Giuseppe
   Tavormina, Maurilio Giuseppe Maria
   Theodorakis, Pavlos N.
   Tohen, Mauricio
   Tsapakis, Eva Maria
   Tukhvatullina, Dina
   Ullah, Irfan
   Vaidya, Ratnaraj
   Vega-Dienstmaier, Johann M.
   Vrublevska, Jelena
   Vukovic, Olivera
   Vysotska, Olga
   Widiasih, Natalia
   Yashikhina, Anna
   Prezerakos, Panagiotis E.
   Smirnova, Daria
TI Somatic multicomorbidity and disability in patients with psychiatric
   disorders in comparison to the general population: a
   quasi-epidemiological investigation in 54,826 subjects from 40 countries
   (COMET-G study)
SO CNS SPECTRUMS
LA English
DT Article
DE Epidemiology; multicomorbidity; disability; premature death;
   somatic-mental comorbidity
ID SERIOUS MENTAL-ILLNESS; SUICIDE ATTEMPTS; GLOBAL BURDEN; RISK-FACTORS;
   MULTIMORBIDITY PATTERNS; EXCESS MORTALITY; PREVALENCE; HEALTH; DISEASE;
   COMORBIDITY
AB Background The prevalence of medical illnesses is high among patients with psychiatric disorders. The current study aimed to investigate multi-comorbidity in patients with psychiatric disorders in comparison to the general population. Secondary aims were to investigate factors associated with metabolic syndrome and treatment appropriateness of mental disorders.Methods The sample included 54,826 subjects (64.73% females; 34.15% males; 1.11% nonbinary gender) from 40 countries (COMET-G study). The analysis was based on the registration of previous history that could serve as a fair approximation for the lifetime prevalence of various medical conditions.Results About 24.5% reported a history of somatic and 26.14% of mental disorders. Mental disorders were by far the most prevalent group of medical conditions. Comorbidity of any somatic with any mental disorder was reported by 8.21%. One-third to almost two-thirds of somatic patients were also suffering from a mental disorder depending on the severity and multicomorbidity. Bipolar and psychotic patients and to a lesser extent depressives, manifested an earlier (15-20 years) manifestation of somatic multicomorbidity, severe disability, and probably earlier death. The overwhelming majority of patients with mental disorders were not receiving treatment or were being treated in a way that was not recommended. Antipsychotics and antidepressants were not related to the development of metabolic syndrome.Conclusions The finding that one-third to almost two-thirds of somatic patients also suffered from a mental disorder strongly suggests that psychiatry is the field with the most trans-specialty and interdisciplinary value and application points to the importance of teaching psychiatry and mental health in medical schools and also to the need for more technocratically oriented training of psychiatric residents.
C1 [Fountoulakis, Konstantinos N.; Karakatsoulis, Grigorios N.] Aristotle Univ Thessaloniki Greece, Sch Med, Dept Psychiat 3, Thessaloniki, Greece.
   [Abraham, Seri] Pennine Care NHS Fdn Trust, Heywood, England.
   [Abraham, Seri] Manchester Metropolitan Univ, Manchester, Lancs, England.
   [Abraham, Seri] Hlth Educ England North West, Core Psychiat Training, Manchester, Lancs, England.
   [Adorjan, Kristina; Falkai, Peter] Ludiwig Maximilians Univ, Dept Psychiat, Munich, Germany.
   [Ahmed, Helal Uddin] Natl Inst Mental Hlth, Child Adolescent & Family Psychiat, Dhaka, Bangladesh.
   [Alarcon, Renato D.] Univ Peruana Cayetano Heredia, Fac Med Alberto Hurtado, Sect Psychiat & Mental Hlth, Lima, Peru.
   [Alarcon, Renato D.] Mayo Clin, Sch Med, Dept Psychiat & Psychol, Rochester, MN USA.
   [Arai, Kiyomi] Shinshu Univ, Inst Hlth Sci, Sch Med & Hlth Sci, Matsumoto, Nagano, Japan.
   [Auwal, Sani Salihu] Bayero Univ, Dept Psychiat, Kano, Nigeria.
   [Auwal, Sani Salihu] Aminu Kano Teaching Hosp, Kano, Nigeria.
   [Berk, Michael; Dodd, Seetal] Deakin Univ, IMPACT Inst Mental & Phys Hlth & Clin Translat, Sch Med, Barwon Hlth, Geelong, Vic, Australia.
   [Berk, Michael; Dodd, Seetal] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Ctr Youth Mental Hlth, Orygen Natl Ctr Excellence Youth Mental Hlth, Melbourne, Vic, Australia.
   [Berk, Michael; Dodd, Seetal] Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia.
   [Bjedov, Sarah; Jaksic, Nenad; Marcinko, Darko; Mustac, Filip] Univ Hosp Ctr Zagreb, Dept Psychiat & Psychol Med, Zagreb, Croatia.
   [Bobes, Julio; Paz Garcia-Portilla, Maria; Saiz, Pilar] Univ Oviedo, Dept Med, Psychiat Area, Oviedo, Spain.
   [Bobes, Julio] Hosp Univ Cent Asturias, Dept Psychiat, Oviedo, Spain.
   [Bobes, Julio; Bobes-Bascaran, Teresa; Garcia-Alvarez, Leticia; Paz Garcia-Portilla, Maria; Saiz, Pilar] CIBERSAM, INEUROPA, ISPA, Oviedo, Spain.
   [Bobes-Bascaran, Teresa; Saiz, Pilar] Mental Hlth Ctr La Corredoria, Oviedo, Spain.
   [Bobes-Bascaran, Teresa; Garcia-Alvarez, Leticia] Univ Oviedo, Dept Psychol, Oviedo, Spain.
   [Bourgin-Duchesnay, Julie; Liewig, Justine; Malashonkova, Evgeniia] Grp Hosp Nord Essonne, Dept Psychiat, Div Child & Adolescent Psychiat, Orsay, France.
   [Bredicean, Cristina Ana; Papava, Ion] Victor Babes Univ Med & Pharm, Dept Neurosci, Discipline Psychiat, Timisoara, Romania.
   [Bukelskis, Laurynas; Hilbig, Jan; Matiekus, Eimantas; Navickas, Alvydas] Vilnius Univ, Inst Clin Med, Fac Med, Clin Psychiat, Vilnius, Lithuania.
   [Burkadze, Akaki; Silagadze, Ketevan] Mental Hub, Tbilisi, Georgia.
   [Burkadze, Akaki] NGO Healthcare Res & Qual Agcy, Tbilisi, Georgia.
   [Cabrera Abud, Indira Indiana] Hosp San Juan de Dios Hosp, Guadalajara, Mexico.
   [Castilla-Puentes, Ruby] Johnson & Johnson, Amer Soc Hispan Psychiat & WARMI Women Mental Hlt, Janssen Res & Dev, Cincinnati, OH USA.
   [Cetkovich, Marcelo] Favaloro Univ, INECO Fdn, Inst Translat & Cognit Neurosci INCyT, Buenos Aires, DF, Argentina.
   [Cetkovich, Marcelo] Natl Sci & Tech Res Council CONICET, Buenos Aires, DF, Argentina.
   [Colon-Rivera, Hector] UPMC, DDAP, APM Board Certified Gen Psychiat & Neurol Addict, Philadelphia, PA USA.
   [Corral, Ricardo] Hosp Borda, Dept Teaching & Res, Buenos Aires, DF, Argentina.
   [Corral, Ricardo] Univ Buenos Aires, Buenos Aires, DF, Argentina.
   [Cortez-Vergara, Carla] Univ Peruana Cayetano Heredia, Clin AngloAmer, Lima, Peru.
   [Crepin, Piirika] Ctr Ambulatory Psychiat Narbonne & Lezigan, Sanit & Social Union Accompaniment & Prevent, Narbonne, France.
   [De Berardis, Domenico; Grandinetti, Paolo] Hosp G Mazzini, ASL Teramo, Dept Mental Hlth Psychiat Serv Diag & Treatment, Teramo, Italy.
   [De Berardis, Domenico] Univ Aquila, Sch Nursing, Laquila, Italy.
   [De Berardis, Domenico] Univ G dAnnunzio, Sch Psychiat, Dept Neurosci & Imaging, Chieti, Italy.
   [Zamora Delgado, Sergio; Grau, Arturo; Vargas Ramirez, Francisca] Hosp Ninos Luis Calvo Mackenna, Child & Adolescent Psychiat Dept, Santiago, Chile.
   [De Lucena, David] Univ Fed Ceara, Dept Fisiol & Farmacol, Fortaleza, Ceara, Brazil.
   [De Sousa, Avinash; Karia, Sagar] Lokmanya Tilak Municipal Gen Hosp & Med Coll, Dept Psychiat, Mumbai, Maharashtra, India.
   [De Sousa, Avinash; Lalljee, Alisha; Mandalia, Bilvesh] Desousa Fdn, Mumbai, Maharashtra, India.
   [Di Stefano, Ramona] Univ Aquila, Sect Psychiat, Dept Biotechnol & Appl Clin Sci, Laquila, Italy.
   [Dodd, Seetal] Univ Hosp Geelong, Barwon Hlth, Geelong, Vic, Australia.
   [Elek, Livia Priyanka; Erdelyi-Hamza, Berta; Gonda, Xenia; Kovacs, Illes; Kulig, Barbara] Semmelweis Univ, Dept Psychiat & Psychotherapy, Budapest, Hungary.
   [Elissa, Anna; Malik, Khamelia; Widiasih, Natalia] Univ Indonesia, Cipto Mangunkusumo Natl Referral Hosp, Dept Psychiat, Fac Med, Jakarta, Indonesia.
   [Erzin, Gamze] Ankara Diskapi Training & Res Hosp, Dept Psychiat, Ankara, Turkiye.
   [Erzin, Gamze] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Med Ctr, Maastricht, Netherlands.
   [Etchevers, Martin J.; Garay, Cristian J.] Univ Buenos Aires UBA, Fac Psychol, Buenos Aires, DF, Argentina.
   [Farcas, Adriana] Queens Univ, Ctr Neurosci, Kingston, ON, Canada.
   [Fedotov, Ilya] Ryazan State Med Univ, Dept Psychiat & Narcol, Ryazan, Russia.
   [Filatova, Viktoriia] State Budgetary Inst Rostov Reg Psychoneurol Disp, Rostov Na Donu, Russia.
   [Fountoulakis, Nikolaos K.] Med Univ Sofia, Fac Med, Sofia, Bulgaria.
   [Frankova, Iryna; Khaustova, Olena] Bogomolets Natl Med Univ, Psychosomat Med & Psychotherapy Dept, Med Psychol, Kiev, Ukraine.
   [Franza, Francesco] Villa dei Pini Psychiat Rehabil Ctr, Avellino, Italy.
   [Franza, Francesco; Tavormina, Giuseppe; Tavormina, Maurilio Giuseppe Maria] Psychiat Studies Ctr, Provaglio Diseo, Italy.
   [Frias, Pedro] Hosp Magalhaes Lemos, Porto, Portugal.
   [Galako, Tatiana] Kyrgyz State Med Acad, Dept Psychiat Med Psychol & Drug Abuse, Bishkek, Kyrgyzstan.
   [Paz Garcia-Portilla, Maria] Mental Hlth Ctr La Eria, Oviedo, Spain.
   [Gondek, Tomasz M.] Polish Psychiat Assoc, Specialty Training Sect, Wroclaw, Poland.
   [Morera Gonzalez, Daniela] Inst Nacl Psiquiatria Ramon De la Fuente Muniz, Mexico City, DF, Mexico.
   [Gould, Hilary; Koh, Steve; Martinez, Stephanie; Mejia, Gabriela] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.
   [Grau, Arturo; Vargas Ramirez, Francisca] Univ Diego Portales, Santiago, Chile.
   [Groudeva, Violeta] Univ Hosp St Ekaterina, Dept Diagnost Imaging, Sofia, Bulgaria.
   [Hagin, Michal] Abarbanel Mental Hlth Ctr, Forens Psychiat Unit, Bat Yam, Israel.
   [Harada, Takayuki] Univ Tsukuba, Educ Bur Lab Sch, Fac Human Sci, Tokyo, Japan.
   [Hasan, Tasdik M.] Univ Liverpool, Dept Primary Care & Mental Hlth, Liverpool, Merseyside, England.
   [Hasan, Tasdik M.] Publ Hlth Fdn, Dhaka, Bangladesh.
   [Hashim, Nurul Azreen; Raduan, Nor Jannah Nasution; Razali, Salmi; Saw, Jo Anne] Univ Teknol MARA, Dept Psychiat, Fac Med, Sungai Buloh, Selangor, Malaysia.
   [Hossain, Sahadat] Jahangirnagar Univ, Dept Publ Hlth & Informat, Dhaka, Bangladesh.
   [Iakimova, Rossitza; Pandova, Milena; Stoyanova, Maria] Univ Hosp Act Treatment Neurol & Psychiat St Naum, Psychiat Clin 2, Sofia, Bulgaria.
   [Ibrahim, Mona; Khalifa, Doaa; Nassieb, Amira; Okasha, Tarek] Ain Shams Univ, Okasha Inst Psychiat, Fac Med, Cairo, Egypt.
   [Iftene, Felicia; Milev, Roumen] Queens Univ, Dept Psychiat, Kingston, ON, Canada.
   [Ignatenko, Yulia; Pavlichenko, Alexey] Educ Ctr, Mental Hlth Clin 1, Moscow, Russia.
   [Irarrazaval, Matias] Minist Hlth Santiago, Millenium Inst Res Depress & Personal, Santiago, Chile.
   [Ismail, Zaliha] Univ Teknol MARA, Dept Publ Hlth Med, Fac Med, Sungai Buloh, Selangor, Malaysia.
   [Ismayilova, Jamila] Minist Hlth Republ Azerbaijan, Natl Mental Hlth Ctr, Baku, Azerbaijan.
   [Jakobs, Asaf] Westchester Med Ctr Hlth Syst, Dept Psychiat, Valhalla, NY USA.
   [Jakobs, Asaf] New York Med Coll, Valhalla, NY 10595 USA.
   [Jakovljevic, Miro; Marcinko, Darko] Univ Zagreb, Sch Med, Zagreb, Croatia.
   [Javed, Afzal] Univ Birmingham, Inst Appl Hlth Res, Birmingham, W Midlands, England.
   [Javed, Afzal] Univ Warwick, Warwick Med Sch, Coventry, W Midlands, England.
   [Javed, Afzal] Pakistan Psychiat Res Ctr, Fountain House, Lahore, Pakistan.
   [Kafali, Helin Yilmaz] Ankara City Hosp, Dept Child Psychiat, Ankara, Turkiye.
   [Kazakova, Olga] Lund Univ, Fac Med, Malmo, Sweden.
   [Kopishinskaia, Svetlana; Yashikhina, Anna; Smirnova, Daria] Samara State Med Univ, Int Ctr Educ & Res Neuropsychiat ICERN, Samara, Russia.
   [Kopishinskaia, Svetlana] Kirov State Med Univ, Kirov, Russia.
   [Kosenko, Korneliia] Odessa Natl Med Univ, Dept Psychiat Drug Abuse & Psychol, Odessa, Ukraine.
   [Koupidis, Sotirios A.] Univ West Attica, Sch Publ Hlth, Publ Hlth Policy Dept, Occupat & Environm Hlth Sect, Athens, Greece.
   [Majid, Abdul] SKIMS Med Coll, Dept Psychiat, Srinagar, India.
   [Malik, Najma Iqbal] Univ Sargodha, Dept Psychol, Sargodha, Pakistan.
   [Mammadzada, Gulay] Azerbaijan Med Univ, Dept Psychiat, Baku, Azerbaijan.
   [Marazziti, Donatella] Univ Pisa, Sect Psychiat, Dept Clin & Expt Med, Pisa, Italy.
   [Marazziti, Donatella] St Camillus Int Univ Hlth Sci, Unicamillus, Rome, Italy.
   [Marazziti, Donatella] Brain Res Fdn Onus, Lucca, Italy.
   [Memon, Roha Saeed] Dow Univ Hlth Sci, Dow Med Coll, Karachi, Pakistan.
   [Meza Martinez, Xarah Elenne] Natl Autonomous Univ Honduras, Postgrad Program Psychiat, Tegucigalpa, Honduras.
   [Mickeviciute, Dalia] Private Outpatient Clin JSC InMed Klin, Vilnius, Lithuania.
   [Mohammed, Muftau] Fed Neuropsychiat Hosp, Dept Clin Serv, Kaduna, Nigeria.
   [Molina-Lopez, Alejandro] Minist Hlth, Gen Off Psychiat Serv, Mexico City, DF, Mexico.
   [Morozov, Petr] Russian Natl Res Med Univ, Dept Postgrad Educ, Moscow, Russia.
   [Muhammad, Nuru Suleiman] Ahmadu Bello Univ Teaching Hosp, Dept Community Med, Zaria, Nigeria.
   [Naor, Mika S.] Tel Aviv Univ, Sackler Sch Med, New York State Amer Program, Tel Aviv, Israel.
   [Panfil, Anca-Livia; Tamasan, Simona Claudia] Pius Brinzeu Cty Emergency Clin Hosp, Compartment Liaison Psychiat, Timisoara, Romania.
   [Panteleeva, Liliya] Kyrgyz Russian Slav Univ, Dept Med Psychol Psychiat & Psychotherapy, Bishkek, Kyrgyzstan.
   [Patsali, Mikaella E.] Hellen Open Univ, Sch Social Sci, Patras, Greece.
   [Patsali, Mikaella E.] Nicosia Gen Hosp, Dept Internal Med, Nicosia, Cyprus.
   [Pejuskovic, Bojana; Vukovic, Olivera] Univ Belgrade, Fac Med, Belgrade, Serbia.
   [Pejuskovic, Bojana] Inst Mental Hlth, Clin Dept Crisis & Affect Disorders, Belgrade, Serbia.
   [Pinto da Costa, Mariana] South London & Maudsley NHS Fdn Trust, London, England.
   [Pinto da Costa, Mariana] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England.
   [Pinto da Costa, Mariana] Univ Porto, Inst Biomed Sci Abel Salazar, Porto, Portugal.
   [Popkov, Mikhail] Int Higher Sch Med, Dept Intro Internal Med & Family Med, Bishkek, Kyrgyzstan.
   [Popovic, Dina] Abarbanel Mental Hlth Ctr, Bat Yam, Israel.
   [Rancans, Elmars; Vrublevska, Jelena] Riga Stradins Univ, Dept Psychiat & Narcol, Riga, Latvia.
   [Rancans, Elmars; Vrublevska, Jelena] Riga Ctr Psychiat & Narcol, Riga, Latvia.
   [Rebok, Federico] Hosp Moyano, Acute Inpatient Unit, Serv Emergencia, Buenos Aires, DF, Argentina.
   [Rebok, Federico] Argentine Inst Clin Psychiat IAPC, Buenos Aires, DF, Argentina.
   [Rewekant, Anna] Greater Poland Neuropsychiat Ctr, Gen Psychiat Unit 1, Koscian, Poland.
   [Reyes Flores, Elena Ninoska] Natl Autonomous Univ Honduras, Dept Psychiat, Tegucigalpa, Honduras.
   [Teresa Rivera-Encinas, Maria] Univ San Martin Porres, Inst Nacl Salud Mental Honorio Delgado Hideyo Nog, Ctr Invest Salud Publ, Fac Med, Lima, Peru.
   [Sanchez de Carmona, Manuel] Anahuac Univ, Fac Hlth Sci, Mexico City, DF, Mexico.
   [Saucedo Martinez, David] Univ Hosp Jose Eleuterio Gonzalez UANL, Escuela Nacl Med, Dept Psychiat, TEC Monterrey,Serv Geriatria, Monterrey, Nuevo Leon, Mexico.
   [Saygili, Gorkem] Tilburg Univ, Dept Cognit Sci & Artificial Intelligence, Tilburg, Netherlands.
   [Schneidereit, Patricia] Klinikum Weissenhof, Psychiat Inst Ambulanz, Klin Allgemeine Psychiat & Psychotherapie Ost, Weissenhof, Germany.
   [Shah, Bhumika] DY Patil Med Coll, Navi Mumbai, Maharashtra, India.
   [Shirasaka, Tomohiro] Teine Keijinkai Med Ctr, Dept Psychiat, Sapporo, Hokkaido, Japan.
   [Sitanggang, Satti] Pambalah Batung Gen Hosp, Psychiat Unit, South Kalimantan, Amuntai, Indonesia.
   [Skugarevsky, Oleg] Belarusian State Med Univ, Dept Psychiat & Med Psychol, Minsk, BELARUS.
   [Spikina, Anna] St Petersburg Psychoneurol Dispensary 2, St Petersburg, Russia.
   [Mahalingappa, Sridevi Sira] Royal Derby Hosp, Derbyshire Healthcare NHS Fdn Trust, Lias Team, Derby, Derbyshire, England.
   [Szczegielniak, Anna] Med Univ Silesia, Fac Med Sci Katowice, Dept Psychiat & Psychotherapy, Dept Psychiat Rehabil, Katowice, Poland.
   [Tavormina, Giuseppe] European Depress Assoc, Brussels, Belgium.
   [Tavormina, Giuseppe] Italian Assoc Depress, Brussels, Belgium.
   [Tavormina, Giuseppe] Univ Cambridge, Bedforshire Ctr Mental Hlth Res, Cambridge, England.
   [Theodorakis, Pavlos N.] WHO Reg Off Europe, Hlth Policy, Copenhagen, Denmark.
   [Tohen, Mauricio] Univ New Mexico, Sch Med, Dept Psychiat & Behav Sci, Albuquerque, NM 87131 USA.
   [Tsapakis, Eva Maria] Agios Charalambos Mental Hlth Clin, Iraklion, Crete, Greece.
   [Tsapakis, Eva Maria] Aristotle Univ Thessaloniki, Sch Med, Dept Acad Psychiat 1, Thessaloniki, Greece.
   [Tukhvatullina, Dina] Queen Mary Univ London, Inst Populat Hlth Sci, Ctr Global Publ Hlth, London, England.
   [Ullah, Irfan] Gandhara Univ, Kabir Med Coll, Peshawar, Pakistan.
   [Vaidya, Ratnaraj] Newcastle Univ, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England.
   [Vega-Dienstmaier, Johann M.] Univ Peruana Cayetano Heredia, Fac Med Alberto Hurtado, Lima, Peru.
   [Vrublevska, Jelena] Riga Stradins Univ, Inst Publ Hlth, Riga, Latvia.
   [Vukovic, Olivera] Inst Mental Hlth, Dept Res & Educ, Belgrade, Serbia.
   [Vysotska, Olga] Bogomolets Natl Med Univ, Ukrainian Family Med Training Ctr, Educ & Res Ctr, Kiev, Ukraine.
   [Yashikhina, Anna; Smirnova, Daria] Samara State Med Univ, Dept Psychiat Narcol Psychotherapy & Clin Psychol, Samara, Russia.
   [Prezerakos, Panagiotis E.] Univ Peloponnese, Lab Integrated Hlth Care, Dept Nursing, Tripoli, Greece.
C3 Aristotle University of Thessaloniki; Manchester Metropolitan
   University; University of Munich; Universidad Peruana Cayetano Heredia;
   Mayo Clinic; Shinshu University; Bayero University; Deakin University;
   Barwon Health; Florey Institute of Neuroscience & Mental Health; Orygen,
   The National Centre of Excellence in Youth Mental Health; University of
   Melbourne; University of Melbourne; University of Zagreb; UNIVERSITY
   ZAGREB HOSPITAL; University of Oviedo; Central University Hospital
   Asturias; Instituto de Investigacion Sanitaria del Principado de
   Asturias (ISPA); CIBER - Centro de Investigacion Biomedica en Red;
   CIBERSAM; University of Oviedo; Victor Babes University of Medicine &
   Pharmacy, Timisoara; Vilnius University; Johnson & Johnson; Johnson &
   Johnson USA; Centro Nacional Patagonico (CENPAT); Consejo Nacional de
   Investigaciones Cientificas y Tecnicas (CONICET); University of Buenos
   Aires; Universidad Peruana Cayetano Heredia; University of L'Aquila; G
   d'Annunzio University of Chieti-Pescara; Universidad de Chile;
   Universidade Federal do Ceara; University of L'Aquila; Barwon Health;
   Geelong Hospital; Semmelweis University; University of Indonesia;
   Diskapi Yildirim Beyazit Training & Research Hospital; Maastricht
   University; University of Buenos Aires; Queens University - Canada;
   Ryazan State Medical University; Medical University Sofia; Bogomolets
   National Medical University; Kyrgyz State Medical Academy; Ministry of
   Health - Kyrgyzstan; Instituto Nacional de Psiquiatria Ramon de la
   Fuente Muniz; University of California System; University of California
   San Diego; University Diego Portales; Medical University Sofia; Tel Aviv
   University; University of Tsukuba; University of Liverpool; Universiti
   Teknologi MARA; Jahangirnagar University; Medical University Sofia;
   Egyptian Knowledge Bank (EKB); Ain Shams University; Queens University -
   Canada; Universiti Teknologi MARA; New York Medical College; University
   of Zagreb; University of Birmingham; University of Warwick; City
   Hospital Ankara; Lund University; Samara State Medical University;
   Odessa National Medical University; University of West Attica;
   Sher-i-Kashmir Institute of Medical Sciences; University of Sargodha;
   Ministry of Education of Azerbaijan Republic; Azerbaijan Medical
   University; University of Pisa; Dow University of Health Sciences; Dow
   Medical College; Universidad Nacional Autonoma de Honduras; Pirogov
   Russian National Research Medical University; Ahmadu Bello University;
   Tel Aviv University; Sackler Faculty of Medicine; Kyrgyz-Russian Slavic
   University; Hellenic Open University; University of Belgrade; South
   London & Maudsley NHS Trust; University of London; King's College
   London; Universidade do Porto; Tel Aviv University; Riga Stradins
   University; Universidad Nacional Autonoma de Honduras; Universidad de
   San Martin de Porres; Universidad Anahuac; Tecnologico de Monterrey;
   Tilburg University; Belarusian State Medical University; University of
   Nottingham; Medical University of Silesia; University of Cambridge;
   World Health Organization; University of New Mexico; Aristotle
   University of Thessaloniki; University of London; Queen Mary University
   London; Newcastle University - UK; Universidad Peruana Cayetano Heredia;
   Riga Stradins University; Bogomolets National Medical University; Samara
   State Medical University; University of Peloponnese
RP Karakatsoulis, GN (corresponding author), Aristotle Univ Thessaloniki Greece, Sch Med, Dept Psychiat 3, Thessaloniki, Greece.
EM gregkarakatsoulis@gmail.com
RI Papava, Ion/ADB-0622-2022; Mammadzada, Gulay/MEO-9675-2025; Pandova,
   Milena/HLW-5143-2023; Vysotska, Olga/AAE-9598-2019; Hashim,
   Nurul/IVH-4311-2023; Stoyanova, Maria/AAB-3741-2020; Fedotov,
   Ilya/KRQ-9818-2024; Rebok, Federico/JYP-4027-2024; Galako,
   Tatiana/AIA-1494-2022; Erzin, Gamze/AAH-5697-2020; Fountoulakis,
   Konstantinos/N-6990-2017; Pinto da Costa, Mariana/AEX-4084-2022; Falkai,
   Peter/E-3273-2017; Popovic, Dina/HOC-3341-2023; Francesco,
   Franza/AFQ-0754-2022; Yashikhina, Anna/ABA-1270-2021; Saw,
   Jo/ABU-3040-2022; Kafalı, Helin/AAN-4210-2020; ISMAIL,
   ZALIHA/GYU-9969-2022; Gondek, Tomasz/LYO-3822-2024; Vega-Dienstmaier,
   Johann/Q-6709-2019; Iakimova, Rossitza/AAD-8441-2022; Szczegielniak,
   Anna Rebeka/IRZ-9609-2023; Desousa, Avinash/AAX-1095-2021; Ullah,
   Irfan/X-2858-2019; Mandalia, Bilvesh/HHZ-5081-2022; Majid,
   Abdul/GRS-9179-2022; Ismayilova, Jamila/U-2648-2019; Irarrazaval,
   Matias/GRO-1960-2022; Vukovic, Olivera/AAP-2960-2020; Groudeva,
   Violeta/AES-9591-2022; Frankova, Iryna/L-8837-2018; Bredicean,
   Cristina/LWI-0320-2024; Hossain, Sahadat/AAB-9052-2019; Adorjan,
   Kristina/NHQ-0385-2025; SANCHEZ, DIEGO/AAA-5440-2019; De Berardis,
   Domenico/HII-7444-2022; Milev, Roumen/F-4521-2012; Mustač,
   Filip/AHI-7952-2022; Navickas, Alvydas/AAJ-9583-2021; malik,
   najma/K-7738-2019; Berk, Michael/AGH-9427-2022; Widiasih,
   Natalia/AAE-5309-2020; Gonda, Xenia/B-2713-2008; Rancans,
   Elmars/IRZ-2854-2023; Garcia-Portilla, Paz/AAC-8272-2020; Bobes
   Bascaran, Maria Teresa/F-2208-2015; Khaustova, Olena/S-3839-2018;
   Jaksic, Nenad/JQI-6576-2023; Panteleeva, Liliia/HBJ-1348-2022;
   Mammadzada, Gulay/N-4192-2016; DE Lucena, David/LBI-5222-2024; RAZALI,
   SALMI/N-4684-2019; Bobes, Julio/AAH-4365-2019; Smirnova,
   Daria/AAN-3195-2020
OI Garcia-Portilla, Paz/0000-0003-3643-1622; Gondek,
   Tomasz/0000-0002-5797-9972; Bobes Bascaran, Maria
   Teresa/0000-0002-5279-504X; Khaustova, Olena/0000-0002-8262-5252;
   GARCIA-ALVAREZ, LETICIA/0000-0001-9482-2993; Navickas,
   Alvydas/0000-0002-6411-7131; Jaksic, Nenad/0000-0002-5286-720X;
   Panteleeva, Liliia/0000-0003-3589-9514; Franza,
   Francesco/0000-0002-2263-3699; Mammadzada, Gulay/0000-0002-3736-9245; DE
   Lucena, David/0000-0002-1547-3711; Szczegielniak, Anna
   Rebeka/0000-0002-2160-4589; RAZALI, SALMI/0000-0003-3955-2729;
   Karakatsoulis, Grigorios/0000-0002-4786-1217; Bobes,
   Julio/0000-0003-2187-4033; Smirnova, Daria/0000-0002-9591-4918;
   Fountoulakis, Konstantinos/0000-0001-5503-0811; Vega-Dienstmaier,
   Johann/0000-0002-5686-4014; Vukovic, Olivera/0000-0001-6898-0007;
   RADUAN, DR. NOR JANNAH NASUTION/0000-0001-7650-262X
CR Agley J, 2021, BMC PUBLIC HEALTH, V21, DOI 10.1186/s12889-020-10103-x
   Amiri P, 2022, FRONT NEUROL, V12, DOI 10.3389/fneur.2021.800605
   Batki SL, 2009, SCHIZOPHR RES, V107, P139, DOI 10.1016/j.schres.2008.10.016
   BEBBINGTON P, 1995, SOC PSYCH PSYCH EPID, V30, P279, DOI 10.1007/BF00805795
   Benyamina A, 2012, LANCET, V379, P29, DOI 10.1016/S0140-6736(12)60021-X
   Bertolote Jose Manoel, 2002, World Psychiatry, V1, P181
   Bobo WV, 2016, J GERONTOL A-BIOL, V71, P1483, DOI 10.1093/gerona/glw032
   Borges G, 2006, PSYCHOL MED, V36, P1747, DOI 10.1017/S0033291706008786
   Borges G, 2010, J CLIN PSYCHIAT, V71, P1617, DOI 10.4088/JCP.08m04967blu
   BOURDON KH, 1992, PUBLIC HEALTH REP, V107, P663
   Chesney E, 2014, WORLD PSYCHIATRY, V13, P153, DOI 10.1002/wps.20128
   Chevassus Hugues, 2004, BMC Clin Pharmacol, V4, P3, DOI 10.1186/1472-6904-4-3
   Cipriano A, 2017, FRONT PSYCHOL, V8, DOI 10.3389/fpsyg.2017.01946
   Collins PY, 2011, NATURE, V475, P27, DOI 10.1038/475027a
   Colton Craig W, 2006, Prev Chronic Dis, V3, pA42
   Correll CU, 2007, CNS SPECTRUMS, V12, P12, DOI 10.1017/S1092852900026298
   de Marco R, 1998, EUR RESPIR J, V11, P599
   de Mooij LD, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00855
   Dembling BP, 1999, PSYCHIATR SERV, V50, P1036, DOI 10.1176/ps.50.8.1036
   Druss B., 2011, Synth Proj Res Synth Rep, V1, P26
   EATON WW, 1991, EPIDEMIOL REV, V13, P320, DOI 10.1093/oxfordjournals.epirev.a036075
   Fairweather-Schmidt AK, 2012, SOC PSYCH PSYCH EPID, V47, P515, DOI 10.1007/s00127-011-0369-5
   Fenton WS, 2006, AM J PSYCHIAT, V163, P1697, DOI 10.1176/appi.ajp.163.10.1697
   Fiest KM, 2017, NEUROLOGY, V88, P296, DOI 10.1212/WNL.0000000000003509
   Fond G, 2019, PROG NEURO-PSYCHOPH, V89, P84, DOI 10.1016/j.pnpbp.2018.08.024
   Fountoulakis KN., 2015, BIPOLAR DISORD, P341
   Fountoulakis KN, 2023, SOC PSYCH PSYCH EPID, V58, P1387, DOI 10.1007/s00127-023-02438-8
   Fountoulakis KN, 2022, PSYCHIAT RES, V315, DOI 10.1016/j.psychres.2022.114702
   Fountoulakis KN, 2022, ACTA NEUROPSYCHIATR, V34, P132, DOI 10.1017/neu.2021.38
   Fountoulakis KN, 2022, EUR NEUROPSYCHOPHARM, V54, P21, DOI 10.1016/j.euroneuro.2021.10.004
   Fountoulakis KN, 2021, J AFFECT DISORDERS, V279, P624, DOI 10.1016/j.jad.2020.10.061
   Fountoulakis KN, 2012, LANCET, V379, P1001, DOI 10.1016/S0140-6736(12)60422-X
   Galenkamp H, 2011, J GERONTOL B-PSYCHOL, V66, P380, DOI 10.1093/geronb/gbr032
   Gold KJ, 2008, J FAM PRACTICE, V57, P515
   Goodwin RD, 2022, AM J PREV MED, V63, P726, DOI 10.1016/j.amepre.2022.05.014
   Gore FM, 2011, LANCET, V377, P2093, DOI 10.1016/S0140-6736(11)60512-6
   Gramaglia E, 2014, J ENDOCRINOL INVEST, V37, P203, DOI 10.1007/s40618-013-0016-y
   GU XH, 1993, LIFE SCI, V52, P687, DOI 10.1016/0024-3205(93)90229-V
   Harhay MO, 2012, LANCET, V379, P27, DOI 10.1016/S0140-6736(12)60019-1
   Harris EC, 1998, BRIT J PSYCHIAT, V173, P11, DOI 10.1192/bjp.173.1.11
   Hoffman C, 1996, JAMA-J AM MED ASSOC, V276, P1473, DOI 10.1001/jama.276.18.1473
   Katon Wayne J, 2011, Dialogues Clin Neurosci, V13, P7
   Kessler RC, 1999, ARCH GEN PSYCHIAT, V56, P617, DOI 10.1001/archpsyc.56.7.617
   Laursen TM, 2009, ARCH GEN PSYCHIAT, V66, P713, DOI 10.1001/archgenpsychiatry.2009.61
   Lawrence D, 2010, CAN J PSYCHIAT, V55, P752, DOI 10.1177/070674371005501202
   Li HB, 2020, AGING-US, V12, P7218, DOI 10.18632/aging.103070
   Lim GY, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-21243-x
   Liu XB, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0207705
   Lucena NL, 2022, CHILD YOUTH SERV REV, V142, DOI 10.1016/j.childyouth.2022.106634
   McGrath J, 2008, EPIDEMIOL REV, V30, P67, DOI 10.1093/epirev/mxn001
   Merikangas KR, 2011, ARCH GEN PSYCHIAT, V68, P241, DOI 10.1001/archgenpsychiatry.2011.12
   Neeleman J, 2001, PSYCHOSOM MED, V63, P239, DOI 10.1097/00006842-200103000-00007
   Nock MK, 2008, BRIT J PSYCHIAT, V192, P98, DOI 10.1192/bjp.bp.107.040113
   Nolte F, 2006, RESP MED, V100, P354, DOI 10.1016/j.rmed.2005.05.012
   O'Connor R., 2000, Understanding suicidal behaviours
   Parekh AK, 2010, JAMA-J AM MED ASSOC, V303, P1303, DOI 10.1001/jama.2010.381
   Parks J., 2006, Morbidity and mortality in people with serious mental illness
   PASSARIELLO N, 1982, J CLIN ENDOCR METAB, V54, P1145, DOI 10.1210/jcem-54-6-1145
   Patsali ME, 2020, PSYCHIAT RES, V292, DOI 10.1016/j.psychres.2020.113298
   Pini S, 2005, EUR NEUROPSYCHOPHARM, V15, P425, DOI 10.1016/j.euroneuro.2005.04.011
   Ronaldson A, 2021, LANCET REG HEALTH-EU, V8, DOI 10.1016/j.lanepe.2021.100149
   Schmidtke A, 1996, ACTA PSYCHIAT SCAND, V93, P327, DOI 10.1111/j.1600-0447.1996.tb10656.x
   Singh P, 2018, CLIN GASTROENTEROL H, V16, P823, DOI 10.1016/j.cgh.2017.06.037
   Suppes T, 2007, PSYCHOPHARMACOL BULL, V40, P22
   Tiihonen J, 2009, LANCET, V374, P620, DOI 10.1016/S0140-6736(09)60742-X
   Van Meter AR, 2023, J AM ACAD CHILD PSY, V62, P973, DOI 10.1016/j.jaac.2022.07.867
   Viron MJ, 2010, PSYCHOSOMATICS, V51, P458, DOI 10.1176/appi.psy.51.6.458
   Walker ER, 2015, JAMA PSYCHIAT, V72, P334, DOI 10.1001/jamapsychiatry.2014.2502
   Weye N, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.6646
   Wittchen HU, 2005, EUR NEUROPSYCHOPHARM, V15, P357, DOI 10.1016/j.euroneuro.2005.04.012
   Wu LT, 2018, DRUG ALCOHOL DEPEN, V192, P316, DOI 10.1016/j.drugalcdep.2018.08.013
   Yao SS, 2020, J AM MED DIR ASSOC, V21, P1282, DOI 10.1016/j.jamda.2019.11.028
NR 72
TC 1
Z9 1
U1 2
U2 16
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 1092-8529
EI 2165-6509
J9 CNS SPECTRUMS
JI CNS Spectr.
PD APR
PY 2024
VL 29
IS 2
BP 126
EP 149
DI 10.1017/S1092852924000026
EA JAN 2024
PG 24
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA NK3B5
UT WOS:001164582600001
PM 38269574
DA 2025-06-11
ER

PT J
AU Kinder, LS
   Carnethon, MR
   Palaniappan, LP
   King, AC
   Fortmann, SP
AF Kinder, LS
   Carnethon, MR
   Palaniappan, LP
   King, AC
   Fortmann, SP
TI Depression and the metabolic syndrome in young adults: Findings from the
   third national health and nutrition examination survey
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE depression; the metabolic syndrome; the third national health and
   nutrition examination survey
ID HEART-RATE-VARIABILITY; CARDIOVASCULAR-DISEASE; PSYCHOLOGICAL-FACTORS;
   MORTALITY; PREVALENCE; ASSOCIATION; RISK; SYMPTOMATOLOGY; PATHOGENESIS;
   POPULATION
AB Objective: Previous reports have suggested that depression may lead to the development of cardiovascular disease through its association with the metabolic syndrome; however, little is known about the relationship between depression and the metabolic syndrome. The aim of this study was to establish an association between depression and the metabolic syndrome in a nationally representative sample. Methods: The Third National Health and Nutrition Examination Survey is a population-based health survey of noninstitutionalized US citizens completed between 1988 and 1994. Three thousand one hundred eighty-six men and 3003 women, age 17 to 39, free of coronary heart disease and diabetes, completed the depression module from the Diagnostic Interview Schedule and a medical examination that provided clinical data needed to establish the presence of the metabolic syndrome, as defined by the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Cholesterol in Adults. Results: Women with a history of a major depressive episode were twice as likely to have the metabolic syndrome compared with those with no history of depression. The relationship between depression and metabolic syndrome remained after controlling for age, race, education, smoking, physical inactivity, carbohydrate consumption, and alcohol use. Men with a history of depression were not significantly more likely to have the metabolic syndrome. Conclusions: The prevalence of the metabolic syndrome is elevated among women with a history of depression. It is important to better understand the role depression may play in the effort to reduce the prevalence of the metabolic syndrome and its health consequences.
C1 Stanford Univ, Sch Med, Stanford Ctr Res Dis Prevent, Stanford, CA USA.
C3 Stanford University
RP VA Puget Hlth Care Syst, 1660 S Columbian Way, Seattle, WA 98108 USA.
EM lskinder@stanfordalumni.org
OI Palaniappan, Latha/0000-0002-1245-665X; King, Abby/0000-0002-7949-8811
FU NHLBI NIH HHS [5 T32 HL 07034, F32 HL 10338] Funding Source: Medline
CR [Anonymous], 1987, DIAGNOSTIC STAT MANU, V4th
   [Anonymous], REF MAN REP
   [Anonymous], VITAL HLTH STAT
   Appels A, 2000, PSYCHOSOM MED, V62, P601, DOI 10.1097/00006842-200009000-00001
   Bjorntorp P, 1997, ACTA PHYSIOL SCAND, V161, P144
   BLUMENTHAL JA, 1982, PSYCHOSOM MED, V44, P519, DOI 10.1097/00006842-198212000-00003
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   CARNEY RM, 1988, J PSYCHOSOM RES, V32, P159, DOI 10.1016/0022-3999(88)90050-5
   CARNEY RM, 1995, AM J CARDIOL, V76, P562, DOI 10.1016/S0002-9149(99)80155-6
   Carney RM, 2001, CIRCULATION, V104, P2024, DOI 10.1161/hc4201.097834
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   DALACK GW, 1990, J CLIN PSYCHIAT, V51, P4
   FINNEGAN DL, 1985, J PSYCHOL, V119, P87
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   GUIRY E, 1987, CLIN CARDIOL, V10, P256, DOI 10.1002/clc.4960100409
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   KESSLER RC, 1994, ARCH GEN PSYCHIAT, V51, P8
   Kinder LS, 2002, HEALTH PSYCHOL, V21, P542, DOI 10.1037//0278-6133.21.6.542
   KLEIGER RE, 1987, AM J CARDIOL, V59, P256, DOI 10.1016/0002-9149(87)90795-8
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   MARCUS MD, 1992, DIABETES CARE, V15, P253, DOI 10.2337/diacare.15.2.253
   McDowell Arthur., 1981, PLAN OPERATION 2 NAT
   MCDOWELL M, 1990, DIETARY DATA COLLECT
   MILLER HW, 1977, PLAN OP HLTH NUTR EX
   Musselman DL, 1998, ARCH GEN PSYCHIAT, V55, P580, DOI 10.1001/archpsyc.55.7.580
   Niaura R, 2000, PSYCHOSOM MED, V62, P7, DOI 10.1097/00006842-200001000-00002
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Raikkonen K, 1996, METABOLISM, V45, P1533, DOI 10.1016/S0026-0495(96)90184-5
   RAVAJA N, 1995, PREV MED, V24, P518, DOI 10.1006/pmed.1995.1082
   Robins L.N., 1991, PSYCHIAT DISORDERS A
   Robins LN., 1981, Diagnostic Interview Schedule: Version III
   Rozanski A, 1999, CIRCULATION, V99, P2192, DOI 10.1161/01.CIR.99.16.2192
   SIMON GE, 1992, AM J EPIDEMIOL, V135, P1411, DOI 10.1093/oxfordjournals.aje.a116252
   Thase ME., 1985, in Handbook of Depression, P816
   Trevisan M, 1998, AM J EPIDEMIOL, V148, P958
   TROXLER RG, 1977, ATHEROSCLEROSIS, V26, P151, DOI 10.1016/0021-9150(77)90098-3
   Tsuji H, 1996, CIRCULATION, V94, P2850, DOI 10.1161/01.CIR.94.11.2850
   *US DEP HHS, 1992, NHANES 3 DIETARY INT
   Wulsin LR, 1999, PSYCHOSOM MED, V61, P6, DOI 10.1097/00006842-199901000-00003
NR 41
TC 270
Z9 310
U1 0
U2 17
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD MAY-JUN
PY 2004
VL 66
IS 3
BP 316
EP 322
DI 10.1097/01.psy.0000124755.91880.f4
PG 7
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 822OA
UT WOS:000221548300005
PM 15184689
DA 2025-06-11
ER

PT J
AU van Leijden, MJ
   Penninx, BWJH
   Agyemang, C
   Olff, M
   Adriaanse, MC
   Snijder, MB
AF van Leijden, Marieke J.
   Penninx, Brenda W. J. H.
   Agyemang, Charles
   Olff, Miranda
   Adriaanse, Marcel C.
   Snijder, Marieke B.
TI The association of depression and posttraumatic stress disorder with the
   metabolic syndrome in a multi-ethnic cohort: the HELIUS study
SO SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
LA English
DT Article
DE Metabolic syndrome; Depression; Posttraumatic stress disorder;
   Ethnicity; HELIUS study
ID PERCEIVED ETHNIC DISCRIMINATION; CORONARY-HEART-DISEASE; CARDIOVASCULAR
   MORTALITY; GENERALIZED ANXIETY; MINORITY-GROUPS; RISK-FACTORS; HEALTH;
   PTSD; PREVALENCE; SYMPTOMS
AB Purpose Depression and posttraumatic stress disorder (PTSD) may be linked to the metabolic syndrome (MetS). Consistency of this association across ethnic groups and the influence of comorbidity of depression/PTSD were examined.
   Methods Cross-sectional baseline data from the HELIUS study were used (4527 Dutch, 2999 South-Asian Surinamese, 4058 African Surinamese, 2251 Ghanaian, 3522 Turkish and 3825 Moroccan participants). The Patient Health Questionnaire-9 (PHQ-9) (score range 0-27) measured depressive symptoms. A 9-item questionnaire (score range 0-9) measured PTSD symptoms. The MetS was defined according to the International Diabetes Federation. The association of a depressed mood (PHQ-9 sum score >= 10) and severe PTSD symptoms (sum score >= 7) with the MetS was examined using logistic regression. Interaction with ethnicity and between a depressed mood and severe PTSD symptoms was tested.
   Results A depressed mood was associated with the MetS [OR (95% CI) = 1.37 (1.24-1.51)] in the total sample and consistent across ethnic groups (p values for interaction all > 0.05). Severe PTSD symptoms were significantly associated with the MetS in the Dutch [OR (95% CI) = 1.71 (1.07-2.73)]. The South-Asian Surinamese, Turks and Moroccans showed weaker associations than the Dutch (p values for interaction all < 0.05). A depressed mood and severe PTSD symptoms did not interact in the association with the MetS (p values for interaction > 0.05).
   Conclusions A depressed mood was consistently associated with the MetS across ethnic groups, but the association between severe PTSD symptoms and the MetS maybe ethnicity dependent. The association with the MetS was not different in case of depressed mood/severe PTSD symptoms comorbidity.
C1 [van Leijden, Marieke J.; Agyemang, Charles; Snijder, Marieke B.] Acad Med Ctr, Dept Publ Hlth, Meibergdreef 15, NL-1105 AZ Amsterdam, Netherlands.
   [Penninx, Brenda W. J. H.] Vrije Univ Amsterdam Med Ctr, Dept Psychiat, Amsterdam Publ Hlth Res Inst, Oldenaller 1, NL-1081 HL Amsterdam, Netherlands.
   [Olff, Miranda] Acad Med Ctr, Dept Psychiat, Meibergdreef 5, NL-1105 AZ Amsterdam, Netherlands.
   [Adriaanse, Marcel C.] Vrije Univ Amsterdam, Dept Hlth Sci, De Boelelaan 1085, NL-1081 HV Amsterdam, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam; Vrije
   Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Vrije Universiteit
   Amsterdam
RP van Leijden, MJ (corresponding author), Acad Med Ctr, Dept Publ Hlth, Meibergdreef 15, NL-1105 AZ Amsterdam, Netherlands.
EM mariekevanleijden.amc@gmail.com
RI Olff, Miranda/S-6235-2019; Adriaanse, Marieke/AFQ-8371-2022; Penninx,
   Brenda WJH/S-7627-2017
OI Olff, Miranda/0000-0003-1016-9515; Penninx, Brenda
   WJH/0000-0001-7779-9672; Adriaanse, Marcel/0000-0002-5085-6662
FU Dutch Heart Foundation [2010T084]; Netherlands Organization for Health
   Research and Development (ZonMw) [200500003]; European Union (FP-7)
   [278901]; European Fund for the Integration of non-EU immigrants (EIF)
   [2013EIF013]
FX The HELIUS study is conducted by the Academic Medical Center Amsterdam
   and the Public Health Service of Amsterdam. Both organizations provided
   core support for HELIUS. The HELIUS study is also funded by the Dutch
   Heart Foundation (2010T084), the Netherlands Organization for Health
   Research and Development (ZonMw) (200500003), the European Union (FP-7)
   (278901), and the European Fund for the Integration of non-EU immigrants
   (EIF) (2013EIF013). We acknowledge the AMC Biobank for their support in
   biobank management and high-quality storage of collected samples. We are
   most grateful to the participants of the HELIUS study and the management
   team, research nurses, interviewers, research assistants and other staff
   who have taken part in gathering the data of this study.
CR Agyemang C, 2012, EUR J PUBLIC HEALTH, V22, P658, DOI 10.1093/eurpub/ckr138
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alegría M, 2013, MED CARE, V51, P1114, DOI 10.1097/MLR.0000000000000007
   Assari S, 2016, RES CARDIOVASC MED, DOI [10.5812/cardiovascmed.34767, DOI 10.5812/CARDIOVASCMED.34767]
   Babic D, 2007, PSYCHIAT DANUB, V19, P68
   Bartoli F, 2015, METABOLISM, V64, P1373, DOI 10.1016/j.metabol.2015.07.017
   Block A, 2016, NORD J PSYCHIAT, V70, P611, DOI 10.1080/08039488.2016.1191535
   Carroll D, 2010, PSYCHOSOM MED, V72, P16, DOI 10.1097/PSY.0b013e3181c4fca1
   Chang JC, 2017, SCI REP-UK, V7, DOI 10.1038/srep41276
   Conway KP, 2017, DRUG ALCOHOL DEPEN, V177, P104, DOI 10.1016/j.drugalcdep.2017.03.032
   DeBoer MD, 2016, INT J OBESITY, V40, P1353, DOI 10.1038/ijo.2016.81
   Dedert EA, 2013, J CLIN PSYCHOL MED S, V20, P46, DOI 10.1007/s10880-012-9305-4
   Dekker LH, 2015, J NUTR, V145, P1884, DOI 10.3945/jn.114.207472
   Eraly SA, 2014, JAMA PSYCHIAT, V71, P423, DOI 10.1001/jamapsychiatry.2013.4374
   Farhood LF, 2016, EUR J PSYCHOTRAUMATO, V7, DOI 10.3402/ejpt.v7.31509
   Farr OM, 2014, METABOLISM, V63, P1463, DOI 10.1016/j.metabol.2014.08.009
   Fassaert T, 2010, PSYCHIAT SERV, V61, P690, DOI 10.1176/ps.2010.61.7.690
   FOA EB, 1993, J TRAUMA STRESS, V6, P459, DOI 10.1002/jts.2490060405
   Galenkamp H, 2017, BMC PSYCHIATRY, V17, DOI 10.1186/s12888-017-1506-9
   Gheshlagh RG, 2016, IRAN RED CRESCENT ME, V18, DOI 10.5812/ircmj.26523
   Gishti O, 2015, PREV MED, V76, P84, DOI 10.1016/j.ypmed.2015.03.027
   Gualdi-Russo E, 2009, J TRAVEL MED, V16, P88, DOI 10.1111/j.1708-8305.2008.00280.x
   Heppner PS, 2009, BMC MED, V7, DOI 10.1186/1741-7015-7-1
   Hiles SA, 2016, DEPRESS ANXIETY, V33, P754, DOI 10.1002/da.22512
   Horesh D, 2017, J AFFECT DISORDERS, V208, P653, DOI 10.1016/j.jad.2016.08.053
   Ikram UZ, 2017, PSYCHOSOM MED, V79, P101, DOI 10.1097/PSY.0000000000000350
   Ikram UZ, 2015, EUR J PUBLIC HEALTH, V25, P243, DOI 10.1093/eurpub/cku180
   Jakovljevic M, 2008, PSYCHIAT DANUB, V20, P406
   Jakovljevic Miro, 2006, Psychiatr Danub, V18, P169
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Kinlein SA, 2015, FRONT PSYCHIATRY, V6, DOI 10.3389/fpsyt.2015.00031
   Kroenke K, 2010, GEN HOSP PSYCHIAT, V32, P345, DOI 10.1016/j.genhosppsych.2010.03.006
   Lamers F, 2018, PSYCHOL MED, V48, P1102, DOI 10.1017/S0033291717002483
   Lewis TT, 2011, CIRC-CARDIOVASC QUAL, V4, P293, DOI 10.1161/CIRCOUTCOMES.110.957548
   Linnville S, 2011, MIL MED, V176, P369, DOI 10.7205/MILMED-D-10-00367
   Marmot M, 2016, EUR J EPIDEMIOL, V31, P639, DOI 10.1007/s10654-016-0174-2
   Martins CS, 2017, DIABETES-METAB RES, V33, DOI 10.1002/dmrr.2842
   Maslov B, 2008, PSYCHIAT DANUB, V20, P384
   Nobles CJ, 2016, J PSYCHOSOM RES, V85, P19, DOI 10.1016/j.jpsychores.2016.03.126
   O'Donovan A, 2016, EVID-BASED MENT HEAL, V19, P120, DOI 10.1136/eb-2016-102376
   Olff M, 2017, CURR OPIN PSYCHOL, V14, P132, DOI 10.1016/j.copsyc.2017.01.001
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Penninx BWJH, 2017, NEUROSCI BIOBEHAV R, V74, P277, DOI 10.1016/j.neubiorev.2016.07.003
   Penninx BWJH, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-129
   Phillips AC, 2009, PSYCHOSOM MED, V71, P395, DOI 10.1097/PSY.0b013e31819e6706
   Read JG, 2007, ETHNIC DIS, V17, P389
   Romeike K, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-3480-4
   Rosenbaum S, 2015, METABOLISM, V64, P926, DOI [10.1016/j.metabol.2015.04.009, 10.1016/j.metabol.2015.01.016]
   Sims M, 2015, ANN EPIDEMIOL, V25, P426, DOI 10.1016/j.annepidem.2015.03.014
   Skogberg N, 2017, INT J CARDIOL, V232, P63, DOI 10.1016/j.ijcard.2017.01.051
   Steudte-Schmiedgen S, 2016, NEUROSCI BIOBEHAV R, V69, P124, DOI 10.1016/j.neubiorev.2016.07.015
   Stronks K, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-402
   Stronks K, 2009, ETHNIC HEALTH, V14, P255, DOI 10.1080/13557850802509206
   Sumner JA, 2015, CIRCULATION, V132, P251, DOI 10.1161/CIRCULATIONAHA.114.014492
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vogelzangs N, 2007, J GERONTOL A-BIOL, V62, P563, DOI 10.1093/gerona/62.5.563
   Weiss T, 2011, GEN HOSP PSYCHIAT, V33, P135, DOI 10.1016/j.genhosppsych.2011.01.002
   Wendel-Vos GCW, 2003, J CLIN EPIDEMIOL, V56, P1163, DOI 10.1016/S0895-4356(03)00220-8
   WHO, 2013, Guidelines for ATC classification and DDD assignment
   Williams ED, 2010, J PSYCHOSOM RES, V69, P379, DOI 10.1016/j.jpsychores.2010.03.015
   Wolf EJ, 2016, PSYCHOL MED, V46, P2215, DOI 10.1017/S0033291716000817
   Yang HB, 2017, EUR J PSYCHOTRAUMATO, V8, DOI 10.1080/20008198.2016.1272789
NR 63
TC 8
Z9 8
U1 0
U2 7
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0933-7954
EI 1433-9285
J9 SOC PSYCH PSYCH EPID
JI Soc. Psychiatry Psychiatr. Epidemiol.
PD SEP
PY 2018
VL 53
IS 9
BP 921
EP 930
DI 10.1007/s00127-018-1533-y
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HE2IK
UT WOS:000453099900006
PM 29796849
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU García-Rivera, BR
   Olguín-Tiznado, JE
   Aranibar, MF
   Ramírez-Barón, MC
   Camargo-Wilson, C
   López-Barreras, JA
   García-Alcaraz, JL
AF Rosa Garcia-Rivera, Blanca
   Everardo Olguin-Tiznado, Jesus
   Fernanda Aranibar, Monica
   Concepcion Ramirez-Baron, Maria
   Camargo-Wilson, Claudia
   Andres Lopez-Barreras, Juan
   Luis Garcia-Alcaraz, Jorge
TI Burnout Syndrome in Police Officers and Its Relationship with Physical
   and Leisure Activities
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE burnout syndrome; fatigue; psychosocial risk factors; work-related
   exhaustion; police
ID METABOLIC SYNDROME; MENTAL-HEALTH; OUT SYNDROME; STRESS; INVENTORY;
   INTERVENTIONS; CONSEQUENCES; PREDICTORS; DEPRESSION; EDUCATION
AB No previous studies in Mexico have been found that jointly analyze physical and leisure activities as variables related to mental health in police officers. This paper presents research on burnout in Mexican Police officers. The question it answers is: is there any association of burnout with physical and leisure activities and personal profile? A total of 276 police officers (87% men and 13% women) participated. To obtain information, the Spanish Burnout Inventory and the Operational Police Stress questionnaires were used. A cross sectional study design was utilized with tests of validity and reliability, goodness of fit, analysis of variance (ANOVA), and analysis of k-means clusters. Results showed that a high number of policemen had high prevalence of burnout and a high level of mental exhaustion, and that exercise was positively and significantly related to lower burnout risk. Men showed higher risk than women. Results should be considered to improve interventions and occupational health practices in the police force. This paper improves understanding of burnout among policemen and the importance of exercise and leisure activities to alleviate burnout.
C1 [Rosa Garcia-Rivera, Blanca; Fernanda Aranibar, Monica; Concepcion Ramirez-Baron, Maria] Autonomous Univ Baja California, Fac Adm & Social Sci, Ensenada 22890, BC, Mexico.
   [Everardo Olguin-Tiznado, Jesus; Camargo-Wilson, Claudia] Autonomous Univ Baja California, Fac Engn Architecture & Design, Ensenada 22860, BC, Mexico.
   [Andres Lopez-Barreras, Juan] Autonomous Univ Baja California, Fac Chem Sci & Engn, Tijuana 20631, BC, Mexico.
   [Luis Garcia-Alcaraz, Jorge] Autonomous Univ Ciudad Juarez, Dept Ind Engn & Mfg, Ciudad Juarez 32310, CHI, Mexico.
C3 Universidad Autonoma de Baja California; Universidad Autonoma de Baja
   California; Universidad Autonoma de Baja California; Universidad
   Autonoma de Ciudad Juarez
RP García-Alcaraz, JL (corresponding author), Autonomous Univ Ciudad Juarez, Dept Ind Engn & Mfg, Ciudad Juarez 32310, CHI, Mexico.
EM blanca_garcia@uabc.edu.mx; jeo179@uabc.edu.mx; maranibar@uabc.edu.mx;
   cony@uabc.edu.mx; ccamargo@uabc.edu.mx; jalopez@uabc.edu.mx;
   jorge.garcia@uacj.mx
RI Tiznado, Jesús/AAW-2674-2020; Garcia-Alcaraz, Jorge Luis/N-9124-2013
OI Garcia-Alcaraz, Jorge Luis/0000-0002-7092-6963; CAMARGO WILSON,
   CLAUDIA/0000-0001-9102-3694; Lopez-Barreras, Juan
   Andres/0000-0002-5477-033X; Garcia-Rivera, Blanca
   Rosa/0000-0003-3114-4114; Olguin Tiznado, Jesus
   Everardo/0000-0002-6205-0973
CR Adams GA, 2010, CRIM JUSTICE BEHAV, V37, P1030, DOI 10.1177/0093854810374282
   Alderden M, 2017, POLICING, V40, P42, DOI 10.1108/PIJPSM-07-2016-0111
   Ament W, 2009, SPORTS MED, V39, P389, DOI 10.2165/00007256-200939050-00005
   [Anonymous], 2003, Handbook of occupational health psychology, DOI [DOI 10.1037/10474-012, 10.1037/10474-012]
   [Anonymous], 2006, REV PSICOL SOC
   Arble E, 2018, STRESS HEALTH, V34, P612, DOI 10.1002/smi.2821
   Arias Gallegos Walter L., 2017, Med. segur. trab., V63, P331
   Bakker AB, 2017, J OCCUP HEALTH PSYCH, V22, P273, DOI 10.1037/ocp0000056
   Basinska BA, 2019, FRONT PSYCHOL, V10, DOI 10.3389/fpsyg.2019.00442
   Bianchi R, 2017, EUR PSYCHIAT, V41, P109, DOI 10.1016/j.eurpsy.2016.10.008
   Bianchi R, 2016, PSYCHIAT RES, V245, P91, DOI 10.1016/j.psychres.2016.08.025
   Bolanle O., 2016, Iafor Journal of Psychology the Behavioral Sciences, V2, P17, DOI [DOI 10.22492/IJPBS.2.3.02, 10.22492/ijpbs.2.3, DOI 10.22492/IJPBS.2.3]
   Brenes MAM., 2012, Rev Cienc Soc (Cr), V3, P65, DOI [10.15517/rcs.v0i137.8419, DOI 10.15517/RCS.V0I137.8419]
   Bürger B, 2018, POLICE PRACT RES, V19, P284, DOI 10.1080/15614263.2017.1419130
   De Lucca D.W., 2017, Police Chief, V84, P1
   Dussault J., 2012, PREVENTING VIOLENCE, P1
   Figueiredo-Ferraz H, 2014, PSICOL-REFLEX CRIT, V27, P291, DOI 10.1590/1678-7153.201427209
   FREUDENBERGER HJ, 1975, PSYCHOTHER-THEOR RES, V12, P73, DOI 10.1037/h0086411
   FREUDENBERGER HJ, 1974, J SOC ISSUES, V30, P159, DOI 10.1111/j.1540-4560.1974.tb00706.x
   Gerber Markus, 2013, BMC Res Notes, V6, P78, DOI 10.1186/1756-0500-6-78
   Gerber M, 2009, SCAND J PUBLIC HEALT, V37, P801, DOI 10.1177/1403494809350522
   Gil-Monte P., 2005, Revista de Psicologia del Trabajo y de las Organizaciones, V21, P107
   Gil-Monte P.R., 2005, QUEMARSE TRABAJO, P37
   GILMONTE PR, 2011, REV MEX PSICOL, V28, P75
   Grant HB, 2019, FRONT PSYCHOL, V9, DOI 10.3389/fpsyg.2018.02793
   Halbesleben JRB, 2006, J APPL BEHAV SCI, V42, P244, DOI 10.1177/0021886305285031
   Holmes ME, 2010, OBES REV, V11, P492, DOI 10.1111/j.1467-789X.2009.00680.x
   Jackson EM, 2006, PSYCHOPHYSIOLOGY, V43, P57, DOI 10.1111/j.1469-8986.2006.00373.x
   Karasek RA, 1990, Healthy work: Stress, productivity, and the reconstruction of working life
   Kis A., 2014, International Journal of Human Sciences, V11, P543, DOI DOI 10.14687/IJHS.V11I2.2922
   Klaperski S, 2014, J BEHAV MED, V37, P1118, DOI 10.1007/s10865-014-9562-9
   Kohlström K, 2017, J WORKPLACE LEARN, V29, P524, DOI 10.1108/JWL-09-2016-0082
   Kompier M, 2016, SCAND J WORK ENV HEA, V42, P355, DOI 10.5271/sjweh.3578
   Kristensen TS, 2005, WORK STRESS, V19, P192, DOI 10.1080/02678370500297720
   Lambert EG, 2008, J APPL SEC RES, V3, P205, DOI 10.1080/19361610802135938
   Lazarus RS, 2000, AM PSYCHOL, V55, P665, DOI 10.1037//0003-066X.55.6.665
   Lopez E., 2000, P INS PUBL GOB DEM R, P1
   Losada Analía Verónica, 2016, Ajayu, V14, P334
   Maria AS, 2018, POLICE Q, V21, P109, DOI 10.1177/1098611117743957
   Maslach C, 2001, ANNU REV PSYCHOL, V52, P397, DOI 10.1146/annurev.psych.52.1.397
   MASLACH C, 1981, J OCCUP BEHAV, V2, P99, DOI 10.1002/job.4030020205
   MASLACH C, 1977, CHILD YOUTH CARE Q, V6, P100, DOI 10.1007/BF01554696
   Maslach C., 1976, Human Behavior, V5, P16
   Maslach C, 2008, J APPL PSYCHOL, V93, P498, DOI 10.1037/0021-9010.93.3.498
   Maslach C, 2012, J ORGAN BEHAV, V33, P296, DOI 10.1002/job.784
   McCarty WP, 2019, POLICE Q, V22, P278, DOI 10.1177/1098611119828038
   Naczenski LM, 2017, J OCCUP HEALTH, V59, P477, DOI 10.1539/joh.17-0050-RA
   Neumann NU, 2009, PSYCHIAT PRAX, V36, P110, DOI 10.1055/s-2008-1067558
   Noblet AJ, 2009, POLICING, V32, P613, DOI 10.1108/13639510911000731
   Obasogie OK, 2017, AM J LAW MED, V43, P279, DOI 10.1177/0098858817723665
   Ochentel O, 2018, J SPORT SCI MED, V17, P475
   Parker P, 2004, BRIT J GUID COUNS, V32, P3, DOI 10.1080/03069880310001648102
   Parveen N., 2009, BAHRIA J PROF PSYCHO, V2, p21 
   PINES A, 1978, HOSP COMMUNITY PSYCH, V29, P233
   Pines AyalaM., 1981, Burnout from tedium to personal growth
   Pinzon N., 2014, SINAPSISREV INVESTIG, V5, P62
   Rosenbaum DP, 2017, POLICING, V40, P71, DOI 10.1108/PIJPSM-07-2016-0114
   Schaible LM, 2016, POLICE Q, V19, P3, DOI 10.1177/1098611115604448
   Schaufeli WB, 2005, WORK STRESS, V19, P256, DOI 10.1080/02678370500385913
   Schaufeli WB, 2009, CAREER DEV INT, V14, P204, DOI 10.1108/13620430910966406
   Schonfeld I.S., 2017, OCCUPATIONAL HLTH PS
   Serna Gomez H.M., 2018, CONTAD ADMIN, P63
   Stinson P.M., 2016, Police integrity lost: A study of law enforcement officers arrested
   Swanson N G, 2000, J Am Med Womens Assoc (1972), V55, P76
   Swider BW, 2010, J VOCAT BEHAV, V76, P487, DOI 10.1016/j.jvb.2010.01.003
   Talavera-Velasco B, 2018, FRONT PSYCHOL, V9, DOI 10.3389/fpsyg.2018.01478
   Toker S, 2012, PSYCHOSOM MED, V74, P840, DOI 10.1097/PSY.0b013e31826c3174
   Tuckey MR, 2012, INT J STRESS MANAGE, V19, P292, DOI 10.1037/a0030317
   Turgoose D., 2017, TRAUMATOLOGY, P205, DOI DOI 10.1037/TRM0000118
   Violanti JM, 2018, POLICE Q, V21, P440, DOI 10.1177/1098611118774764
   White LM, 2015, PSYCHOL SERV, V12, P291, DOI 10.1037/ser0000031
   Yoo HL, 2009, J OCCUP ENVIRON MED, V51, P46, DOI 10.1097/JOM.0b013e31817f9e43
   Zedeck S., 1992, WORK FAMILIES ORG, P1
   Zeta P., SUMAN 1280 ASESINATO
NR 74
TC 21
Z9 25
U1 2
U2 25
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD AUG
PY 2020
VL 17
IS 15
AR 5586
DI 10.3390/ijerph17155586
PG 17
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA NL2NL
UT WOS:000567258600001
PM 32756344
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Fond, G
   Godin, O
   Schürhoff, F
   Berna, F
   Bulzacka, E
   Andrianarisoa, M
   Brunel, L
   Aouizerate, B
   Capdevielle, D
   Chereau, I
   Coulon, N
   D'Amato, T
   Dubertret, C
   Dubreucq, J
   Faget, C
   Lançon, C
   Leignier, S
   Mallet, J
   Misdrahi, D
   Passerieux, C
   Rey, R
   Schandrin, A
   Urbach, M
   Vidailhet, P
   Leboyer, M
   Boyer, L
   Llorca, PM
AF Fond, G.
   Godin, O.
   Schurhoff, F.
   Berna, F.
   Bulzacka, E.
   Andrianarisoa, M.
   Brunel, L.
   Aouizerate, B.
   Capdevielle, D.
   Chereau, I.
   Coulon, N.
   D'Amato, T.
   Dubertret, C.
   Dubreucq, J.
   Faget, C.
   Lancon, C.
   Leignier, S.
   Mallet, J.
   Misdrahi, D.
   Passerieux, C.
   Rey, R.
   Schandrin, A.
   Urbach, M.
   Vidailhet, P.
   Leboyer, M.
   Boyer, L.
   Llorca, P. M.
CA FACE-SZ FondaMental Acad Ctr Exper
TI Hypovitaminosis D is associated with depression and anxiety in
   schizophrenia: Results from the national FACE-SZ cohort
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Vitamin D; Schizophrenia; Depression; Anxiety; Metabolic syndrome
ID LOW VITAMIN-D; PREMORBID INTELLIGENCE LEVELS; METABOLIC SYNDROME; D
   SUPPLEMENTATION; D DEFICIENCY; DISORDERS; SYMPTOMS; INFLAMMATION;
   RELIABILITY; PREVALENCE
AB Objective: Hypovitaminosis D has been associated with respectively major depressive disorder, schizophrenia (SZ) and cognitive disorders in the general population, and with positive and negative symptoms and metabolic syndrome in schizophrenia. The objectives were (i) to determine the prevalence of hypovitaminosis D and associated factors (with a focus on depression and cognition) in a national non-selected multicentric sample of community-dwelling SZ subjects (ii) to determine the rate of SZ patients being administered vitamin D supplementation and associated factors.
   Methods: A comprehensive 2 daylong clinical and neuropsychological battery was administered in 140 SZ subjects included between 2015 and 2017 in the national FondaMental Expert Center (FACE-SZ) Cohort. Hypovitaminosis D was defined by blood vitamin D level <25 nM. Depressive symptoms were assessed by the Positive and Negative Syndrome Scale depressive subscore and current anxiety disorder by the Structured Clinical Interview for Mental Disorders.
   Results: Hypovitaminosis D has been found in 21.4% of the subjects and none of them had received vitamin D supplementation in the previous 12 months. In multivariate analysis, hypovitaminosis D has been significantly associated with respectively higher depressive symptoms (aOR = 1.18 [1.03-1.35], p = 0.02) and current anxiety disorder (aOR = 6.18 [2.15-17.75], p = 0.001), independently of age and gender. No association of hypovitaminosis D with respectively positive and negative symptoms, cognitive scores or other biological variables has been found (all p > 0.05), however, a trend toward significance has been found for metabolic syndrome (p = 0.06). Vitamin D supplementation has been administered during the previous 12 months in only 8.5% of the subjects but was associated with lower depressive symptoms (aOR = 0.67 [0.46-0.98], p = 0.04) and lower rate of current anxiety disorder (aOR = 0.06 [0.01-0.66],p = 0.02) compared to patients with hypovitaminosis D.
   Conclusion: Hypovitaminosis D is frequent and associated with depressive symptoms and anxiety disorders in schizophrenia. Vitamin D supplementation is associated with lower depressive and anxiety symptoms, however patients with hypovitaminosis D remain insufficiently treated.
C1 [Fond, G.; Godin, O.; Schurhoff, F.; Berna, F.; Bulzacka, E.; Andrianarisoa, M.; Brunel, L.; Aouizerate, B.; Capdevielle, D.; Chereau, I.; Coulon, N.; D'Amato, T.; Dubertret, C.; Dubreucq, J.; Faget, C.; Lancon, C.; Leignier, S.; Mallet, J.; Misdrahi, D.; Passerieux, C.; Rey, R.; Schandrin, A.; Urbach, M.; Leboyer, M.; Boyer, L.; Llorca, P. M.] Fdn FondaMental, Creteil, France.
   [Schurhoff, F.; Bulzacka, E.; Andrianarisoa, M.; Brunel, L.; Coulon, N.; Leboyer, M.] Univ Paris Est Creteil, Pole Psychiat Hop Univ H Mondor, DHU Pe PSY, INSERM U955,Equipe Psychiat Translat, Creteil, France.
   [Fond, G.; Faget, C.; Lancon, C.; Boyer, L.] Aix Marseille Univ, Fac Med, Sect Timone, AP HM,EA 3279,CEReSS Ctr Etud & Rech Serv Sante &, 27 Blvd Jean Moulin, F-13005 Marseille, France.
   [Aouizerate, B.; Misdrahi, D.] Univ Bordeaux, Ctr Hosp Charles Perrens, F-33076 Bordeaux, France.
   [Berna, F.; Vidailhet, P.] Univ Strasbourg, Hop Univ Strasbourg, INSERM U1114, Federat Med Translat Strasbourg, Strasbourg, France.
   [Capdevielle, D.; Schandrin, A.] Univ Montpellier I, CHRU Montpellier, Inserrn 1061, Serv Univ Psychiat Adulte,Hop Colombiere, Montpellier, France.
   [Chereau, I.; Llorca, P. M.] Univ Auvergne, Fac Med, EA 7280, CMP B,CHU, BP 69, F-63003 Clermont Ferrand, France.
   [D'Amato, T.] Univ Claude Bernard Lyon 1, Ctr Hosp Le Vinatier, Ctr Rech Neurosci Lyon, INSERM U1028,CNRS UMR5292,Pole Est, 95 Bd Pinel,BP 30039, F-69678 Bron, France.
   [Dubertret, C.; Mallet, J.] Univ Paris Diderot, Sorbonne Paris Cite, Fac Med, AP HP,Dept Psychiat,Louis Mourier Hosp,Colombes,I, Paris, France.
   [Dubreucq, J.; Leignier, S.] CH Alpes Isere, Ctr Referent Rehabil Psychosociale, Grenoble, France.
   [Passerieux, C.; Urbach, M.] Univ Versailles St Quentin en Yvelines, UFR Sci Sante Simone Veil, EA 4047 HANDIReSP, Ctr Hosp Versailles,Serv Psychiat & Addictol Adul, Versailles, France.
   [Aouizerate, B.] Univ Bordeaux, NutriNeuro, INRA, U1286, F-33076 Bordeaux, France.
   [Misdrahi, D.] INCIA, CNRS UMR 5287, Bordeaux, France.
   [Godin, O.] UPMC Univ Paris 06, Sorbonne Univ, Inst Pierre Louis Epiderniol & Sante Publ, INSERM,UMR S 1136, F-75013 Paris, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Assistance Publique Hopitaux Paris (APHP); Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Hopital Universitaire
   Henri-Mondor - APHP; Aix-Marseille Universite; Assistance
   Publique-Hopitaux de Marseille; Universite de Bordeaux; Universites de
   Strasbourg Etablissements Associes; Universite de Strasbourg; CHU
   Strasbourg; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite de Montpellier; CHU de Montpellier; Universite
   Clermont Auvergne (UCA); CHU Clermont Ferrand; Centre National de la
   Recherche Scientifique (CNRS); Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Claude Bernard Lyon 1;
   Universite Jean Monnet; CNRS - National Institute for Biology (INSB);
   Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Louis-Mourier - APHP; Centre Hospitalier de
   Versailles; Universite Paris Saclay; Universite de Bordeaux; INRAE;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Bordeaux; Centre National de la Recherche Scientifique
   (CNRS); CNRS - National Institute for Biology (INSB); Institut National
   de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite
RP Fond, G (corresponding author), Aix Marseille Univ, Fac Med, Sect Timone, EA 3279,CEReSS Ctr Etud & Rech Serv Sante & Qual, 27 Blvd Jean Moulin, F-13005 Marseille, France.
EM guillaume.fond@ap-hm.fr
RI Schandrin, Aurélie/ISV-4608-2023; Berna, Fabrice/J-2701-2019;
   Capdevielle, Delphine/HTO-4229-2023; TESSIER, Arnaud/A-4022-2017;
   COULON, Nathalie/HLW-3075-2023; Leboyer, Marion/AAW-3648-2021; Boyer,
   Laurent/E-5728-2016; FOND, Guillaume/D-7646-2011
OI dubreucq, julien/0000-0003-4079-4194; Aouizerate,
   Bruno/0000-0002-7092-7747; Capdevielle, Delphine/0000-0002-7146-8554;
   COULON, Nathalie/0000-0001-7765-1117; Misdrahi,
   David/0000-0003-1146-3206; LEBOYER, Marion/0000-0001-5473-3697; D'Amato,
   Thierry/0000-0001-8983-0315; FOND, Guillaume/0000-0003-3249-2030
FU AP-HM (Assistance Publique des Hopitaux de Marseille); Fondation
   FondaMental (RTRS Sante Mentale); Investissements d'Avenir program
   [ANR-11-IDEX-0004-02, ANR-10-COH0-10-01]
FX This work was funded by AP-HM (Assistance Publique des Hopitaux de
   Marseille), Fondation FondaMental (RTRS Sante Mentale), by the
   Investissements d'Avenir program managed by the ANR under reference
   ANR-11-IDEX-0004-02 and ANR-10-COH0-10-01.
CR Adamson J, 2017, PSYCHIAT RES, V249, P78, DOI 10.1016/j.psychres.2016.12.052
   Akinlade KS, 2017, FRONT PSYCHIATRY, V8, DOI 10.3389/fpsyt.2017.00105
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Andrianarisoa M, 2017, SCHIZOPHR RES, V185, P173, DOI 10.1016/j.schres.2016.12.021
   [Anonymous], 1994, Doors and People: A Test of Visual and Verbal Recall and Recognition. Manual
   Archontogeorgis K, 2018, METAB SYNDR RELAT D, V16, P190, DOI 10.1089/met.2017.0181
   Barbalho SM, 2018, DIABETES METAB SYND, V12, P501, DOI 10.1016/j.dsx.2018.03.011
   Belzeaux R, 2015, PSYCHIAT RES, V229, P613, DOI 10.1016/j.psychres.2015.04.039
   Bender R, 2001, J CLIN EPIDEMIOL, V54, P343, DOI 10.1016/S0895-4356(00)00314-0
   Boerman R, 2016, J CLIN PSYCHOPHARM, V36, P588, DOI 10.1097/JCP.0000000000000580
   Bogers JPAM, 2016, NORD J PSYCHIAT, V70, P262, DOI 10.3109/08039488.2015.1086023
   Bulut SD, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0165284
   Cieslak K, 2014, SCHIZOPHR RES, V159, P543, DOI 10.1016/j.schres.2014.08.031
   Custodero C, 2018, AGEING RES REV, V46, P42, DOI 10.1016/j.arr.2018.05.004
   Delis D.C., 2000, Manual for the California Verbal Learning Test, (CVLT-II)
   Firth J, 2018, SCHIZOPHRENIA BULL, V44, P1275, DOI 10.1093/schbul/sbx162
   Fond G, 2019, EUR ARCH PSY CLIN N, V269, P879, DOI 10.1007/s00406-018-0932-0
   Fond G, 2018, BRIT J PSYCHIAT, V213, P464, DOI 10.1192/bjp.2018.87
   Fond G, 2013, J AFFECT DISORDERS, V149, P418, DOI 10.1016/j.jad.2012.11.066
   Garbossa SG, 2017, REV ENDOCR METAB DIS, V18, P243, DOI 10.1007/s11154-017-9423-2
   Godefroy O., 2008, Fonctions executives et pathologies neurologiques et psychiatriques
   Graham KA, 2015, EARLY INTERV PSYCHIA, V9, P397, DOI 10.1111/eip.12122
   Harvey Philip D, 2011, Innov Clin Neurosci, V8, P14
   Itzhaky D, 2012, ISR MED ASSOC J, V14, P88
   Ju SY, 2013, J NUTR HEALTH AGING, V17, P447, DOI 10.1007/s12603-012-0418-0
   Kim D, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18091949
   Krivoy A, 2017, EBIOMEDICINE, V26, P138, DOI 10.1016/j.ebiom.2017.11.027
   Lerner PP, 2018, CLIN NUTR ESPEN, V23, P89, DOI 10.1016/j.clnesp.2017.11.011
   Leventhal AM, 2008, PSYCHIAT RES, V161, P43, DOI 10.1016/j.psychres.2007.10.014
   Mackinnon A, 2005, ENCEPHALE, V31, P31
   Murri MB, 2013, SCHIZOPHR RES, V150, P235, DOI 10.1016/j.schres.2013.07.017
   NELSON HE, 1978, CORTEX, V14, P234, DOI 10.1016/S0010-9452(78)80049-5
   Nerhus M, 2016, SCHIZOPHR RES, V178, P44, DOI 10.1016/j.schres.2016.08.024
   Nuechterlein KH, 2008, AM J PSYCHIAT, V165, P203, DOI 10.1176/appi.ajp.2007.07010042
   Poitrenaud J., 2007, Adaptation en langue francaise du California Verbal Learning Test [French language adaptation of the California Verbal Learning Test]
   REITAN R. M., 1958, PERCEPT MOT SKILLS, V8, P271
   Roux P, 2018, J CLIN PSYCHIAT, V79, DOI 10.4088/JCP.17m11638
   Ryan JJ, 1999, PSYCHOL ASSESSMENT, V11, P207, DOI 10.1037/1040-3590.11.2.207
   Schefft C, 2017, EUR NEUROPSYCHOPHARM, V27, P1090, DOI 10.1016/j.euroneuro.2017.07.004
   Schürhoff F, 2015, EUR PSYCHIAT, V30, P728, DOI 10.1016/j.eurpsy.2015.05.004
   Shivakumar V, 2015, PSYCHIAT RES-NEUROIM, V233, P175, DOI 10.1016/j.pscychresns.2015.06.006
   Souberbielle JC, 2016, ENDOCRINE, V53, P543, DOI 10.1007/s12020-016-0960-3
   Tardelli VS, 2017, PSYCHIAT RES, V248, P83, DOI 10.1016/j.psychres.2016.10.051
   Unite de surveillance et d'epiderniologie nutritionnelle, 2007, ET NAT NUTR SANT ENN, P46
   Wallwork RS, 2012, SCHIZOPHR RES, V137, P246, DOI 10.1016/j.schres.2012.01.031
   Wang S, 2018, ENDOCRINE, V59, P499, DOI 10.1007/s12020-018-1532-5
   Wechsler D., 2008, ECHEILE INTELLIGENCE
   Yoo T, 2018, PSYCHIAT INVEST, V15, P396, DOI 10.30773/pi.2017.08.30
   Yüksel RN, 2014, THER ADV PSYCHOPHARM, V4, P268, DOI 10.1177/2045125314553612
   Zhu DM, 2015, PSYCHIAT RES, V228, P565, DOI 10.1016/j.psychres.2015.05.051
   Zhu W, 2018, DIABETES METAB SYND, V12, P727, DOI 10.1016/j.dsx.2018.04.010
NR 51
TC 22
Z9 22
U1 1
U2 10
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD DEC
PY 2018
VL 270
BP 104
EP 110
DI 10.1016/j.psychres.2018.09.024
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HG4VH
UT WOS:000454972600013
PM 30245372
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Heppner, PS
   Lohr, JB
   Kash, TP
   Jin, H
   Wang, HJ
   Baker, DG
AF Heppner, Pia S.
   Lohr, James B.
   Kash, Taylor P.
   Jin, Hua
   Wang, Hongjun
   Baker, Dewleen G.
TI Metabolic Syndrome: Relative Risk Associated with Post-Traumatic Stress
   Disorder (PTSD) Severity and Antipsychotic Medication Use
SO PSYCHOSOMATICS
LA English
DT Article
ID CORONARY-HEART-DISEASE; DIABETES-MELLITUS; ALLOSTASIS; PREVALENCE;
   DIAGNOSIS; MORTALITY; SYMPTOMS; VETERANS
AB Background: In recent years, numerous lines of converging evidence have revealed an association between post-traumatic stress disorder (PTSD) and impaired physical health outcomes, including cardiovascular disease and metabolic syndrome. Although these findings have been interpreted as indicating a direct association of PTSD with metabolic syndrome and obesity, previous studies have not addressed the important confound of antipsychotic drug usage in this population. Second generation antipsychotic medications themselves are associated with metabolic syndrome and obesity, and it is unclear whether the common utilization of these drugs in PTSD may account for some if not all of the observed metabolic problems. Objective: The present study examined the relative contributions of PTSD severity and use of antipsychotic medications to risk of metabolic syndrome among veterans. Method: Cross-sectional clinical data, including five factors representing metabolic syndrome, psychiatric diagnoses, and medications were gathered from 253 veterans enrolling in mental health services. We used a logistic regression model to measure the relative association of antipsychotic medication use and PTSD severity on risk of metabolic syndrome. Results: We found that antipsychotic medication usage was not uniquely associated with elevated risk of metabolic syndrome (Wald = 0.30, ns) when PTSD severity and other sociodemographic, psychiatric, and behavioral variables were accounted for. Furthermore, PTSD severity continued to be a significant and unique predictor of risk for metabolic syndrome (Wald = 4.04, p < 0.05). Conclusions: These findings suggest that chronic and moderately severe PTSD, independent of antipsychotic medications, is associated with increased risk of metabolic syndrome. (Psychosomatics 2012; 53:550-558)
C1 [Baker, Dewleen G.] VA San Diego Healthcare Syst, VA Ctr Excellence Stress & Mental Hlth 116A, San Diego, CA 92161 USA.
   [Heppner, Pia S.; Lohr, James B.; Baker, Dewleen G.] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.
   [Lohr, James B.; Jin, Hua; Wang, Hongjun; Baker, Dewleen G.] VA Ctr Excellence Stress & Mental Hlth, San Diego, CA USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA San Diego Healthcare System; University of California System;
   University of California San Diego
RP Baker, DG (corresponding author), VA San Diego Healthcare Syst, VA Ctr Excellence Stress & Mental Hlth 116A, 3350 La Jolla Village Dr, San Diego, CA 92161 USA.
EM dgbaker@ucsd.edu
RI jin, hua/AAX-1569-2020; Wang, Hongjun/AAJ-3852-2020; Baker,
   Dewleen/O-4957-2019
FU VA Research mechanisms (VA Cooperative Study Program); VA Center of
   Excellence for Stress and Mental Health (CESAMH)
FX This study, data collection, and analysis have been funded by through VA
   Research mechanisms (VA Cooperative Study Program) and the VA Center of
   Excellence for Stress and Mental Health (CESAMH). The study acknowledges
   data collection efforts of Cincinnati VA PTSD and Gulf War Program staff
   and researchers.
CR Ahearn EP, 2011, INT CLIN PSYCHOPHARM, V26, P193, DOI 10.1097/YIC.0b013e3283473738
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Babic D, 2007, PSYCHIAT DANUB, V19, P68
   BLAKE DD, 1995, J TRAUMA STRESS, V8, P75, DOI 10.1007/BF02105408
   Boscarino JA, 2008, PSYCHOSOM MED, V70, P668, DOI 10.1097/PSY.0b013e31817bccaf
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Coughlin SS, 2011, OPEN CARDIOVASC MED, V5, P164, DOI 10.2174/1874192401105010164
   First M.B., 2016, User's Guide for the SCID-5-CV Structured Clinical Interview for DSM-5 Disorders: Clinical Version
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Hasnain M, 2010, CURR DIABETES REP, V10, P209, DOI 10.1007/s11892-010-0112-8
   Haupt DW, 2002, J PSYCHOSOM RES, V53, P925, DOI 10.1016/S0022-3999(02)00471-3
   Heppner PS, 2009, BMC MED, V7, DOI 10.1186/1741-7015-7-1
   Jakovljevic Miro, 2006, Psychiatr Danub, V18, P169
   Jin H, 2009, J CLIN PSYCHOPHARM, V29, P210, DOI 10.1097/JCP.0b013e3181a45ed0
   Kibler JL, 2009, J TRAUMA DISSOCIATIO, V10, P135, DOI 10.1080/15299730802624577
   Kibler JL, 2009, BEHAV MED, V34, P125, DOI 10.3200/BMED.34.4.125-132
   Kohli P, 2006, JAMA-J AM MED ASSOC, V295, P819, DOI 10.1001/jama.295.7.819
   Krystal JH, 2011, JAMA-J AM MED ASSOC, V306, P493, DOI 10.1001/jama.2011.1080
   Kubzansky LD, 2007, ARCH GEN PSYCHIAT, V64, P109, DOI 10.1001/archpsyc.64.1.109
   Laaksonen DE, 2002, AM J EPIDEMIOL, V156, P1070, DOI 10.1093/aje/kwf145
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Leslie DL, 2009, PSYCHIAT SERV, V60, P1174, DOI 10.1176/ps.2009.60.9.1175
   McEwen BS, 2000, NEUROCHEM RES, V25, P1219, DOI 10.1023/A:1007687911139
   McEwen BS, 1998, ANN NY ACAD SCI, V840, P33, DOI 10.1111/j.1749-6632.1998.tb09546.x
   McFarlane AC, 2010, WORLD PSYCHIATRY, V9, P3
   Muhtz C, 2011, J NERV MENT DIS, V199, P646, DOI 10.1097/NMD.0b013e318229cfba
   Reynolds GP, 2010, PHARMACOL THERAPEUT, V125, P169, DOI 10.1016/j.pharmthera.2009.10.010
   SMEETS R.M. W., 1993, Composite international diagnostic interview, version 1.1
   Stahl SM, 2009, ACTA PSYCHIAT SCAND, V119, P171, DOI 10.1111/j.1600-0447.2008.01334.x
   Trief PM, 2006, J BEHAV MED, V29, P411, DOI 10.1007/s10865-006-9067-2
   Vieweg WVR, 2007, ACTA PSYCHIAT SCAND, V116, P483, DOI 10.1111/j.1600-0447.2007.01071.x
   Violanti John M, 2006, Int J Emerg Ment Health, V8, P227
   Weathers FW, 2001, DEPRESS ANXIETY, V13, P132, DOI 10.1002/da.1029
NR 34
TC 24
Z9 25
U1 0
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0033-3182
EI 1545-7206
J9 PSYCHOSOMATICS
JI Psychosomatics
PD NOV-DEC
PY 2012
VL 53
IS 6
BP 550
EP 558
DI 10.1016/j.psym.2012.05.005
PG 9
WC Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 049KC
UT WOS:000311980900006
PM 23157993
OA Bronze
DA 2025-06-11
ER

PT J
AU Toschi-Dias, E
   Trombetta, IC
   da Silva, VJD
   Maki-Nunes, C
   Alves, MJNN
   Angelo, LF
   Cepeda, FX
   Martinez, DG
   Negrao, CE
   Rondon, MUPB
AF Toschi-Dias, Edgar
   Trombetta, Ivani C.
   Dias da Silva, Valdo Jose
   Maki-Nunes, Cristiane
   Alves, Maria Janieire N. N.
   Angelo, Luciana F.
   Cepeda, Felipe X.
   Martinez, Daniel G.
   Negrao, Carlos Eduardo
   Rondon, Maria Urbana P. B.
TI Symptoms of anxiety and mood disturbance alter cardiac and peripheral
   autonomic control in patients with metabolic syndrome
SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE Anxiety; Mood disturbance; Sympathetic activity; Baroreflex sensitivity;
   Metabolic syndrome
ID HEART-RATE-VARIABILITY; BAROREFLEX SENSITIVITY; BLOOD-PRESSURE; STRESS;
   EXERCISE; ACTIVATION; DEPRESSION; HYPOTHALAMUS; HYPERTENSION; VOLUME
AB Previous investigations show that metabolic syndrome (MetSyn) causes sympathetic hyperactivation. Symptoms of anxiety and mood disturbance (AMd) provoke sympatho-vagal imbalance. We hypothesized that AMd would alter even further the autonomic function in patients with MetSyn. Twenty-six never-treated patients with MetSyn (ATP-III) were allocated to two groups, according to the levels of anxiety and mood disturbance: (1) with AMd (MetSyn + AMd, n = 15), and (2) without AMd (MetSyn, n = 11). Ten healthy control subjects were also studied (C, n = 10). AMd was determined using quantitative questionnaires. Muscle sympathetic nerve activity (MSNA, microneurography), blood pressure (oscillometric beat-to-beat basis), and heart rate (ECG) were measured during a baseline 10-min period. Spectral analysis of RR interval and systolic arterial pressure were analyzed, and the power of low (LF) and high (HF) frequency bands were determined. Sympatho-vagal balance was obtained by LF/HF ratio. Spontaneous baroreflex sensitivity (BRS) was evaluated by calculation of alpha-index. MSNA was greater in patients with MetSyn + AMd compared with MetSyn and C. Patients with MetSyn + AMd showed higher LF and lower HF power compared with MetSyn and C. In addition, LF/HF balance was higher in MetSyn + AMd than in MetSyn and C groups. BRS was decreased in MetSyn + AMd compared with MetSyn and C groups. Anxiety and mood disturbance alter autonomic function in patients with MetSyn. This autonomic dysfunction may contribute to the increased cardiovascular risk observed in patients with mood alterations.
C1 [Toschi-Dias, Edgar; Trombetta, Ivani C.; Maki-Nunes, Cristiane; Alves, Maria Janieire N. N.; Angelo, Luciana F.; Cepeda, Felipe X.; Martinez, Daniel G.; Negrao, Carlos Eduardo; Rondon, Maria Urbana P. B.] Univ Sao Paulo, Sch Med, Heart Inst InCor, BR-05508030 Sao Paulo, Brazil.
   [Dias da Silva, Valdo Jose] Univ Fed Triangulo Mineiro, Sch Med, Uberaba, MG, Brazil.
   [Negrao, Carlos Eduardo; Rondon, Maria Urbana P. B.] Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade Federal do Triangulo Mineiro;
   Universidade de Sao Paulo
RP Rondon, MUPB (corresponding author), Univ Sao Paulo, Sch Phys Educ & Sport, Av Prof Mello de Moraes,65 Butanta, BR-05508030 Sao Paulo, Brazil.
EM urbana@usp.br
RI Negrao, Carlos/C-4281-2012; Toschi-Dias, Edgar/C-9685-2013; Toschi-Dias,
   Edgar/AAP-9528-2020; Trombetta, Ivani/G-5839-2012; Alves, Maria
   Janieire/G-4548-2010; Pinto Brandao Rondon, Maria Urbana/G-5272-2012;
   Godoy Martinez, Daniel/D-9135-2015; Xerez Cepeda, Felipe/G-3340-2013
OI Pinto Brandao Rondon, Maria Urbana/0000-0002-4134-6126; Godoy Martinez,
   Daniel/0000-0003-0034-7963; Toschi-Dias, Edgar/0000-0002-5226-2956;
   Negrao, Carlos Eduardo/0000-0003-4652-1226; Xerez Cepeda,
   Felipe/0000-0003-1544-3499
FU Conselho Nacional de Pesquisa (CNPq) [476385/2006-7, 140643/2009-5,
   301867/2010-0, 308068/2011-4]; Fundacao de Amparo a Pesquisa do Estado
   de Sao Paulo (FAPESP) [2010/50048-1]; Fundacao Zerbini; Fundacao de
   Amparo a Pesquisa (FAPESP) [2008/03714-6]; Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES); Fundacao de Amparo
   a Pesquisa do Estado de Sao Paulo (FAPESP) [10/50048-1, 08/03714-6]
   Funding Source: FAPESP; Swedish Research Council [2008-03714] Funding
   Source: Swedish Research Council
FX This study was supported by Conselho Nacional de Pesquisa (CNPq #
   476385/2006-7), by Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
   (FAPESP # 2010/50048-1) and, in part, by Fundacao Zerbini. Toschi-Dias
   E, Negrao CE and Rondon MUPB were supported by Conselho Nacional de
   Pesquisa (CNPq # 140643/2009-5, # 301867/2010-0, # 308068/2011-4,
   respectively). Trombetta IC was supported by Fundacao de Amparo a
   Pesquisa (FAPESP # 2008/03714-6). Maki-Nunes C and Martinez DG were
   supported by Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
   (CAPES).
CR Andrade L, 2001, BRAZ J MED BIOL RES, V34, P367, DOI 10.1590/S0100-879X2001000300011
   Bao AM, 2008, BRAIN RES REV, V57, P531, DOI 10.1016/j.brainresrev.2007.04.005
   Bardwell WA, 2003, AM J PSYCHIAT, V160, P350, DOI 10.1176/appi.ajp.160.2.350
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   Contoreggi C, 2003, BIOL PSYCHIAT, V54, P873, DOI 10.1016/S0006-3223(03)00167-7
   Fuchs E, 2003, PHYSIOL BEHAV, V79, P417, DOI 10.1016/S0031-9384(03)00161-6
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Gianaros PJ, 2008, J NEUROSCI, V28, P990, DOI 10.1523/JNEUROSCI.3606-07.2008
   Grassi G, 2005, DIABETOLOGIA, V48, P1359, DOI 10.1007/s00125-005-1798-z
   Grassi G, 2001, HYPERTENSION, V38, P1316, DOI 10.1161/hy1201.096117
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Huggett RJ, 2004, HYPERTENSION, V44, P847, DOI 10.1161/01.HYP.0000147893.08533.d8
   Jackson K, 2005, J NEUROPHYSIOL, V94, P3211, DOI 10.1152/jn.00277.2005
   Kop WJ, 2011, BIOL PSYCHOL, V86, P230, DOI 10.1016/j.biopsycho.2010.12.003
   La Rovere MT, 2001, CIRCULATION, V103, P2072
   Lambert E, 2010, J HYPERTENS, V28, P543, DOI 10.1097/HJH.0b013e3283350ea4
   Laterza MC, 2007, HYPERTENSION, V49, P1298, DOI 10.1161/HYPERTENSIONAHA.106.085548
   Lucini D, 2006, J HYPERTENS, V24, P361, DOI 10.1097/01.hjh.0000202817.02836.9c
   Lucini D, 2005, HYPERTENSION, V46, P1201, DOI 10.1161/01.HYP.0000185147.32385.4b
   MALLIANI A, 1991, CIRCULATION, V84, P482, DOI 10.1161/01.CIR.84.2.482
   Martinez DG, 2011, HYPERTENSION, V58, P1049, DOI 10.1161/HYPERTENSIONAHA.111.176644
   McEwen BS, 2007, PHYSIOL REV, V87, P873, DOI 10.1152/physrev.00041.2006
   MONTANO N, 1994, CIRCULATION, V90, P1826, DOI 10.1161/01.CIR.90.4.1826
   PAGANI M, 1988, HYPERTENSION, V12, P600, DOI 10.1161/01.HYP.12.6.600
   PAGANI M, 1986, CIRC RES, V59, P178, DOI 10.1161/01.RES.59.2.178
   Pruessner JC, 2005, NEUROIMAGE, V28, P815, DOI 10.1016/j.neuroimage.2005.06.014
   Rosmond R, 2005, PSYCHONEUROENDOCRINO, V30, P1, DOI 10.1016/j.psyneuen.2004.05.007
   Scott JPR, 2006, PHYSIOL BEHAV, V87, P396, DOI 10.1016/j.physbeh.2005.11.009
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   VALLBO AB, 1979, PHYSIOL REV, V59, P919, DOI 10.1152/physrev.1979.59.4.919
   Virtanen R, 2003, PSYCHOSOM MED, V65, P751, DOI 10.1097/01.PSY.0000088760.65046.CF
NR 31
TC 9
Z9 10
U1 0
U2 26
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1439-6319
J9 EUR J APPL PHYSIOL
JI Eur. J. Appl. Physiol.
PD MAR
PY 2013
VL 113
IS 3
BP 671
EP 679
DI 10.1007/s00421-012-2476-8
PG 9
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA 087PF
UT WOS:000314773500013
PM 22918560
DA 2025-06-11
ER

PT J
AU Viinamäki, H
   Heiskanen, T
   Lehto, SM
   Niskanen, L
   Koivumaa-Honkanen, H
   Tolmunen, T
   Honkalampi, K
   Saharinen, T
   Haatainen, K
   Hintikka, J
AF Viinamaki, H.
   Heiskanen, T.
   Lehto, S. M.
   Niskanen, L.
   Koivumaa-Honkanen, H.
   Tolmunen, T.
   Honkalampi, K.
   Saharinen, T.
   Haatainen, K.
   Hintikka, J.
TI Association of depressive symptoms and metabolic syndrome in men
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE depression; metabolic syndrome; population-based
ID C-REACTIVE PROTEIN; INTERNATIONAL-DIABETES-FEDERATION; 3RD
   NATIONAL-HEALTH; YOUNG-ADULTS; RISK-FACTORS; US ADULTS; MORTALITY;
   PREVALENCE; ANXIETY; POPULATION
AB Objective: To explore the relationship between several indicators of depression and metabolic syndrome (MetS).
   Method: A population-based sample with high (HMS group) or low (LMS group) levels of mental symptoms, including those of depression, in three follow-ups participated in a clinical examination in 2005 (n = 223). MetS was determined according to the NCEP criteria.
   Results: The prevalence of MetS was 49% in men and 21% in women. Men with MetS had higher rates of major depressive disorder than other men. They also displayed higher Hamilton Rating Scale for Depression (HDRS) scores and more often signs of suicidality. In logistic regression analyses, higher HDRS scores (OR 1.31, 95% CI 1.04-1.64) and belonging to the HMS group (OR 10.1, 95% CI 1.98-51.3) were independent associates for MetS but only in men.
   Conclusion: The results highlight that there is an association between long-term depressive symptoms and the emergence of MetS, especially in men.
C1 [Viinamaki, H.; Heiskanen, T.; Lehto, S. M.; Niskanen, L.; Koivumaa-Honkanen, H.; Tolmunen, T.; Honkalampi, K.; Saharinen, T.; Haatainen, K.; Hintikka, J.] Kuopio Univ Hosp, Dept Psychiat, FIN-70211 Kuopio, Finland.
   [Viinamaki, H.; Heiskanen, T.; Lehto, S. M.; Niskanen, L.; Koivumaa-Honkanen, H.; Tolmunen, T.; Honkalampi, K.; Saharinen, T.; Haatainen, K.; Hintikka, J.] Kuopio Univ Hosp, Dept Med, FIN-70211 Kuopio, Finland.
   [Viinamaki, H.; Heiskanen, T.; Lehto, S. M.; Niskanen, L.; Koivumaa-Honkanen, H.; Tolmunen, T.; Honkalampi, K.; Saharinen, T.; Haatainen, K.; Hintikka, J.] Univ Kuopio, Inst Clin Med, FIN-70211 Kuopio, Finland.
   [Koivumaa-Honkanen, H.] Univ Oulu, Inst Clin Med, Oulu, Finland.
   [Koivumaa-Honkanen, H.] Muurola Hosp, Lapland Hosp Dist, Rovaniemi, Finland.
C3 Kuopio University Hospital; Kuopio University Hospital; University of
   Eastern Finland; University of Oulu
RP Viinamäki, H (corresponding author), Kuopio Univ Hosp, Dept Psychiat, POB 1777, FIN-70211 Kuopio, Finland.
EM heimo.viinamaki@kuh.fi
RI Koivumaa-Honkanen, Heli/L-1274-2015
OI Lehto, Soili/0000-0003-4324-6679
FU Kuopio University Hospital; Academy of Finland [116996]; Academy of
   Finland (AKA) [116996] Funding Source: Academy of Finland (AKA)
FX The clinical study of subjects was supported with an EVO grant from
   Kuopio University Hospital. HK-H is supported by a grant from the
   Academy of Finland ( 116996).
CR BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   Chan O, 2003, Minerva Endocrinol, V28, P87
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   *FDA, 21888 FDA NDA
   First MB., 2002, STRUCTURED CLIN INTE
   Ford DE, 2004, ARCH INTERN MED, V164, P1010, DOI 10.1001/archinte.164.9.1010
   Ford ES, 2005, DIABETES CARE, V28, P2745, DOI 10.2337/diacare.28.11.2745
   Gil Katarzyna, 2006, Kardiol Pol, V64, P464
   Guize L, 2006, B ACAD NAT MED PARIS, V190, P685, DOI 10.1016/S0001-4079(19)33302-3
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Hildrum B, 2007, BMC PUBLIC HEALTH, V7, DOI 10.1186/1471-2458-7-220
   Hintikka J, 1998, ACTA PSYCHIAT SCAND, V98, P23, DOI 10.1111/j.1600-0447.1998.tb10037.x
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jilma B, 1997, J LAB CLIN MED, V130, P69, DOI 10.1016/S0022-2143(97)90060-3
   Joukamaa M, 2001, NORD J PSYCHIAT, V55, P123, DOI 10.1080/08039480151108561
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Koivumaa-Honkanen H, 2000, AM J EPIDEMIOL, V152, P983, DOI 10.1093/aje/152.10.983
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178, DOI 10.4088/JCP.v69n0202
   Laaksonen DE, 2004, DIABETOLOGIA, V47, P1403, DOI 10.1007/s00125-004-1472-x
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Li CY, 2008, DIABETES CARE, V31, P105, DOI 10.2337/dc07-1154
   Liukkonen T, 2006, BIOL PSYCHIAT, V60, P825, DOI 10.1016/j.biopsych.2006.02.016
   Lustman PJ, 2007, PSYCHOSOM MED, V69, P297, DOI 10.1097/PSY.0b013e318060cc2d
   Miettola J, 2008, SCAND J PRIM HEALTH, V26, P203, DOI 10.1080/02813430802117624
   Murray CJL, 1997, LANCET, V349, P1436, DOI 10.1016/S0140-6736(96)07495-8
   Musselman DL, 2003, BIOL PSYCHIAT, V54, P317, DOI 10.1016/S0006-3223(03)00569-9
   Mykletun A, 2007, PSYCHOSOM MED, V69, P323, DOI 10.1097/PSY.0b013e31803cb862
   Okamura F, 2000, METABOLISM, V49, P1255, DOI 10.1053/meta.2000.9515
   PALINKAS LA, 1991, DIABETIC MED, V8, P532, DOI 10.1111/j.1464-5491.1991.tb01646.x
   Pirkola SP, 2005, SOC PSYCH PSYCH EPID, V40, P1, DOI 10.1007/s00127-005-0848-7
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Räikkönen K, 2007, DIABETES CARE, V30, P872, DOI 10.2337/dc06-1857
   Scheen AJ, 2006, LANCET, V368, P1660, DOI 10.1016/S0140-6736(06)69571-8
   Schmidtke A, 1996, ACTA PSYCHIAT SCAND, V93, P327, DOI 10.1111/j.1600-0447.1996.tb10656.x
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   THIRLAWAY K, 1992, J PSYCHOSOM RES, V36, P657, DOI 10.1016/0022-3999(92)90055-7
   Toker S, 2008, DEPRESS ANXIETY, V25, P661, DOI 10.1002/da.20379
   Vogelzangs N, 2007, PSYCHONEUROENDOCRINO, V32, P151, DOI 10.1016/j.psyneuen.2006.11.009
   Vuorilehto M, 2005, PSYCHOL MED, V35, P673, DOI 10.1017/S0033291704003770
   Weber-Hamann B, 2006, PSYCHONEUROENDOCRINO, V31, P347, DOI 10.1016/j.psyneuen.2005.08.014
NR 41
TC 60
Z9 64
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
EI 1600-0447
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD JUL
PY 2009
VL 120
IS 1
BP 23
EP 29
DI 10.1111/j.1600-0447.2008.01333.x
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 453TP
UT WOS:000266636100004
PM 19133875
DA 2025-06-11
ER

PT J
AU Hadi, A
   Sepandi, M
   Marx, W
   Moradi, S
   Parastouei, K
AF Hadi, Amir
   Sepandi, Mojtaba
   Marx, Wolfgang
   Moradi, Sajjad
   Parastouei, Karim
TI Clinical and psychological responses to synbiotic supplementation in
   obese or overweight adults: A randomized clinical trial
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Article
DE Synbiotics; Microbiome; Obesity; Metabolic profile; Depression; Anxiety;
   Stress
ID METABOLIC SYNDROME; PROBIOTICS; DISEASE; CHOLESTEROL; MICROBIOME;
   PREBIOTICS; DEPRESSION; MANAGEMENT; BURDEN; UPDATE
AB Background: Obesity is highly prevalent worldwide. Emerging clinical studies suggest that pre- and pro- biotic formulations may be effective interventions for the management of obesity and associated metabolic complications. The current trial was conducted to assess the effect of synbiotic supplementation on anthropometric indices, glycemic and lipid profile, blood pressure, and psychological status of adults with overweight or obesity.
   Methods: This randomized double-blind, placebo-controlled trial was conducted on 60 adults with overweight or obesity. Participants were randomly assigned into two groups to receive either synbiotics (n = 30) in form of a 500 mg capsule (containing Lactobacillus acidophilus, Lactobacillus casei and Bifidobacterium bifidum plus inulin) or placebo (n = 30) for 8 weeks. The level of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), fasting blood glucose (FPG), insulin, body weight, body mass index (BMI), waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), stress, anxiety, and depression were measured at the baseline and end of the study.
   Results: In total, 59 subjects (39 men and 20 women) completed the present study. A significant between-group decrease in body weight (P = 0.03), TC (P = 0.01), TG (P = 0.02), LDL-C (P = 0.01), stress (P < 0.001), anxiety (P = 0.03), and depression (P = 0.03) was found in the synbiotic group compared to the placebo. However, synbiotics had no significant effect on HDL-C, SBP, DBP, FPG and fasting insulin concentrations, as well the BMI and WC (P < 0.05).
   Conclusion: The present study showed that synbiotic supplementation can confer a number of health benefits including improvements in TG, TC, LDL-C, body weight, stress, anxiety, and depression to subjects that are overweight or obesity.
C1 [Hadi, Amir; Sepandi, Mojtaba; Parastouei, Karim] Baqiyatallah Univ Med Sci, Hlth Res Ctr, Life Style Inst, Tehran, Iran.
   [Hadi, Amir; Parastouei, Karim] Baqiyatallah Univ Med Sci, Fac Hlth, Dept Nutr & Food Hyg, Tehran, Iran.
   [Sepandi, Mojtaba] Baqiyatallah Univ Med Sci, Fac Hlth, Dept Epidemiol & Biostat, Tehran, Iran.
   [Marx, Wolfgang] Deakin Univ, Sch Med, iMPACT, Geelong, Vic, Australia.
   [Moradi, Sajjad] FDA, Halal Res Ctr, IRI, Tehran, Iran.
C3 Baqiyatallah University of Medical Sciences (BMSU); Baqiyatallah
   University of Medical Sciences (BMSU); Baqiyatallah University of
   Medical Sciences (BMSU); Deakin University
RP Parastouei, K (corresponding author), Baqiyatallah Univ Med Sci, Hlth Res Ctr, Life Style Inst, Tehran, Iran.
EM Parastouei@gmail.com
RI Marx, Wolfgang/AFO-7355-2022; Sepandi, Mojtaba/I-8561-2014; Hadi,
   Amir/AAK-4634-2020
OI Marx, Wolfgang/0000-0002-8556-8230
CR Akin A, 2007, EGIT ARAST, V7, P1
   Akkasheh G, 2016, NUTRITION, V32, P315, DOI 10.1016/j.nut.2015.09.003
   [Anonymous], Circulation
   [Anonymous], J NUTR
   [Anonymous], 2018, NUTRIENTS
   [Anonymous], COMPLEMENT THER MED
   [Anonymous], BIOL TRACE ELEM RES
   [Anonymous], CRIT REV FOOD SCI NU
   [Anonymous], EUR J CLIN NUTR
   [Anonymous], CRIT REV FOOD SCI NU
   [Anonymous], 2016, IMMUNOPATHOL PERSA
   Bäckhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Bäckhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   Barczynska R, 2015, POL J MICROBIOL, V64, P93
   Ciorba MA, 2012, CLIN GASTROENTEROL H, V10, P960, DOI 10.1016/j.cgh.2012.03.024
   Cowburn G, 1997, BRIT MED BULL, V53, P389, DOI 10.1093/oxfordjournals.bmb.a011619
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   Desbonnet L, 2008, J PSYCHIATR RES, V43, P164, DOI 10.1016/j.jpsychires.2008.03.009
   Dinan TG, 2017, GASTROENTEROL CLIN N, V46, P77, DOI 10.1016/j.gtc.2016.09.007
   Faith MS, 2011, OBES REV, V12, pe438, DOI 10.1111/j.1467-789X.2010.00843.x
   Fernandes R, 2017, CLIN NUTR, V36, P1197, DOI 10.1016/j.clnu.2016.10.003
   Fijan S, 2014, INT J ENV RES PUB HE, V11, P4745, DOI 10.3390/ijerph110504745
   Firth J, 2019, WORLD PSYCHIATRY, V18, P308, DOI 10.1002/wps.20672
   Fox M, 2019, ANN NY ACAD SCI, V1449, P3, DOI 10.1111/nyas.14129
   Ghaderi A, 2019, BMC PSYCHIATRY, V19, DOI 10.1186/s12888-019-2059-x
   Ghorbani Z, 2018, ARCH NEUROSCI, V5, DOI 10.5812/archneurosci.60507
   Grundy SM, 2004, J CLIN ENDOCR METAB, V89, P2595, DOI 10.1210/jc.2004-0372
   Kaila B, 2008, CAN J GASTROENTEROL, V22, P61, DOI 10.1155/2008/609039
   Kelly T, 2008, INT J OBESITY, V32, P1431, DOI 10.1038/ijo.2008.102
   Kuczmarski RJ, 2000, AM J CLIN NUTR, V72, P1074
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Lye HS, 2010, J DAIRY SCI, V93, P1383, DOI 10.3168/jds.2009-2574
   McKean J, 2017, J ALTERN COMPLEM MED, V23, P249, DOI 10.1089/acm.2016.0023
   Miraghajani M, 2017, J RENAL NUTR, V27, P317, DOI 10.1053/j.jrn.2017.04.004
   Mohammadi H, 2019, COMPLEMENT THER MED, V44, P269, DOI 10.1016/j.ctim.2019.05.008
   Must A, 1999, JAMA-J AM MED ASSOC, V282, P1523, DOI 10.1001/jama.282.16.1523
   Ogden CL, 2003, ENDOCRIN METAB CLIN, V32, P741, DOI 10.1016/S0889-8529(03)00074-4
   Ooi LG, 2010, INT J MOL SCI, V11, P2499, DOI 10.3390/ijms11062499
   Özdemir Ö, 2010, CLIN EXP IMMUNOL, V160, P295, DOI 10.1111/j.1365-2249.2010.04109.x
   Paek Kyung-Won, 2006, J Prev Med Public Health, V39, P59
   Pandey KR, 2015, J FOOD SCI TECH MYS, V52, P7577, DOI 10.1007/s13197-015-1921-1
   PENA F, 2014, J FOOD NUTR RES, V2, P491, DOI DOI 10.12691/JFNR-2-8-10
   Pereira DIA, 2002, APPL ENVIRON MICROB, V68, P4689, DOI 10.1128/AEM.68.9.4689-4693.2002
   Prados-Bo Andreu, 2015, Nutr Hosp, V31 Suppl 1, P10, DOI 10.3305/nh.2015.31.sup1.8702
   Rabiei S, 2018, J Diet Suppl, P1
   Sahebi A., 2005, Iranian Psychologists, V4, P299
   Saulnier DM, 2013, GUT MICROBES, V4, P17, DOI 10.4161/gmic.22973
   Schulz KF, 2010, BMJ-BRIT MED J, V340, DOI 10.1136/bmj.c332
   Skrypnik K, 2019, FOOD FUNCT, V10, P5228, DOI [10.1039/c9fo01006h, 10.1039/C9FO01006H]
   Smith-Ryan AE, 2019, APPL PHYSIOL NUTR ME, V44, P765, DOI 10.1139/apnm-2018-0645
   Szulinska M, 2016, BIOMED ENVIRON SCI, V29, P706, DOI 10.3967/bes2016.095
   Tamtaji OR, 2019, CLIN NUTR, V38, P1031, DOI 10.1016/j.clnu.2018.05.018
   Thakur V, 2001, AM J MED SCI, V321, P242, DOI 10.1097/00000441-200104000-00005
   Upadhyay J, 2018, MED CLIN N AM, V102, P13, DOI 10.1016/j.mcna.2017.08.004
   Verna Elizabeth C, 2010, Therap Adv Gastroenterol, V3, P307, DOI 10.1177/1756283X10373814
   Williams NT, 2010, AM J HEALTH-SYST PH, V67, P449, DOI 10.2146/ajhp090168
   Wu YC, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0178868
NR 58
TC 47
Z9 47
U1 0
U2 37
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD DEC
PY 2019
VL 47
AR 102216
DI 10.1016/j.ctim.2019.102216
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA JU4JI
UT WOS:000501643500038
PM 31780038
DA 2025-06-11
ER

PT J
AU Al-Khatib, Y
   Akhtar, MA
   Kanawati, MA
   Mucheke, R
   Mahfouz, M
   Al-Nufoury, M
AF Al-Khatib, Yousef
   Akhtar, Muhammad Adeel
   Kanawati, M. Ali
   Mucheke, Rumbidzai
   Mahfouz, Maria
   Al-Nufoury, Maysan
TI Depression and Metabolic Syndrome: A Narrative Review
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE depression and diabetes; cardiovascular complications; metabolic
   syndrome; depression; obesity
ID MAJOR DEPRESSION; PSYCHOLOGICAL DISTRESS; CARDIOVASCULAR-DISEASE;
   BIPOLAR DISORDER; MENTAL-DISORDERS; RISK-FACTORS; JOLLY FAT; US ADULTS;
   OBESITY; ASSOCIATION
AB We reviewed the literature to investigate the relationship between depression and metabolic syndrome. Major depressive disorder is characterized by a low mood or a loss of interest for longer than two weeks. Metabolic syndrome describes multiple metabolic risk factors including obesity, insulin resistance, dyslipidemia, and hypertension. We divided our findings into environmental, genetic, epigenetic, and biological pathway links between depression and the different aspects of metabolic syndrome. We found various sources linking obesity and metabolic syndrome genetically, environmentally, biological pathway-wise, and, while not fully explored, epigenetically. Diabetes and depression were also found to be linked environmentally with both conditions increasing the risk of the other. Depression was also shown to be linked to cardiovascular complications as it increased the risk of occurrence of such complications in healthy people. These findings have led us to believe that there is a link between depression and metabolic syndrome on various levels, especially obesity.
C1 [Al-Khatib, Yousef] Royal Coll Surgeons Ireland, Orthopaed, Dublin, Ireland.
   [Akhtar, Muhammad Adeel] Royal Coll Surgeons Ireland, Trauma & Orthopaed, Dublin, Ireland.
   [Kanawati, M. Ali] Royal Coll Surgeons Ireland, Internal Med, Dublin, Ireland.
   [Mucheke, Rumbidzai] Univ Huddersfield, Operating Dept Practice, Huddersfield, W Yorkshire, England.
   [Mahfouz, Maria] Royal Coll Surgeons Ireland, Med, Dublin, Ireland.
   [Al-Nufoury, Maysan] Spinney Hosp, Psychiat, Manchester, Lancs, England.
C3 Royal College of Surgeons - Ireland; Royal College of Surgeons -
   Ireland; Royal College of Surgeons - Ireland; University of
   Huddersfield; Royal College of Surgeons - Ireland
RP Al-Khatib, Y (corresponding author), Royal Coll Surgeons Ireland, Orthopaed, Dublin, Ireland.
EM yousefal-khatib@outlook.com
RI Akhtar, Muhammad Shaheer/GPX-0675-2022
CR Afari N, 2010, DEPRESS ANXIETY, V27, P799, DOI 10.1002/da.20704
   [Anonymous], 1985, RELATIONSHIP OBESITY
   Archer T, 2013, J Genet Syndr Gene Ther, V4
   Association AP, 2013, Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
   Bornstein SR, 2006, MOL PSYCHIATR, V11, P892, DOI 10.1038/sj.mp.4001873
   Carey M, 2014, BRIT J GEN PRACT, V64, pE122, DOI 10.3399/bjgp14X677482
   Chou KL, 2013, DEPRESS ANXIETY, V30, P574, DOI 10.1002/da.22098
   Choy WC, 2009, PSYCHIAT GENET, V19, P32, DOI 10.1097/YPG.0b013e328320804e
   CRISP AH, 1980, J PSYCHOSOM RES, V24, P233, DOI 10.1016/0022-3999(80)90013-6
   CRISP AH, 1976, BRIT MED J, V1, P7, DOI 10.1136/bmj.1.6000.7
   de Wit L, 2010, PSYCHIAT RES, V178, P230, DOI 10.1016/j.psychres.2009.04.015
   del Giudice EM, 2006, DEPRESS ANXIETY, V23, P90, DOI 10.1002/da.20156
   Dixon JB, 2003, ARCH INTERN MED, V163, P2058, DOI 10.1001/archinte.163.17.2058
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   Everson SA, 2002, J PSYCHOSOM RES, V53, P891, DOI 10.1016/S0022-3999(02)00303-3
   Faith MS, 2011, OBES REV, V12, pe438, DOI 10.1111/j.1467-789X.2010.00843.x
   Farmer A, 2008, BRIT J PSYCHIAT, V192, P351, DOI 10.1192/bjp.bp.107.038380
   Foley DL, 2010, TWIN RES HUM GENET, V13, P347, DOI 10.1375/twin.13.4.347
   Geoffroy MC, 2014, PSYCHOL MED, V44, P2641, DOI 10.1017/S0033291714000142
   Ghosh S, 2010, BMC MED GENOMICS, V3, DOI 10.1186/1755-8794-3-56
   Gil Katarzyna, 2006, Kardiol Pol, V64, P464
   Gluckman PD, 2008, INT J OBESITY, V32, pS62, DOI 10.1038/ijo.2008.240
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Golden SH, 2007, CURR DIABETES REV, V3, P252, DOI 10.2174/157339907782330021
   HALLSTROM T, 1981, J PSYCHOSOM RES, V25, P75, DOI 10.1016/0022-3999(81)90093-3
   Han TS, 1998, AM J PUBLIC HEALTH, V88, P1814, DOI 10.2105/AJPH.88.12.1814
   Han TS., 2015, Medicine, V43, P80, DOI DOI 10.1016/J.MPMED.2014.11.006
   Hasler G, 2005, MOL PSYCHIATR, V10, P842, DOI 10.1038/sj.mp.4001671
   Heiskanen TH, 2006, J CLIN PSYCHIAT, V67, P1422, DOI 10.4088/JCP.v67n0913
   Heo M, 2006, INT J OBESITY, V30, P513, DOI 10.1038/sj.ijo.0803122
   Herva A, 2006, INT J OBESITY, V30, P520, DOI 10.1038/sj.ijo.0803174
   Hildrum B, 2009, DIABETOLOGIA, V52, P583, DOI 10.1007/s00125-009-1271-5
   Holt RIG, 2014, DIABETES CARE, V37, P2067, DOI 10.2337/dc13-2134
   Hrabosky JI, 2008, CLIN PSYCHOL-SCI PR, V15, P28, DOI 10.1111/j.1468-2850.2008.00108.x
   ISTVAN J, 1992, INT J OBESITY, V16, P999
   Jokela M, 2012, GENES BRAIN BEHAV, V11, P942, DOI 10.1111/j.1601-183X.2012.00846.x
   Kahl KG, 2015, BRAIN BEHAV, V5, DOI 10.1002/brb3.306
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Kivimäki M, 2011, AM J EPIDEMIOL, V173, P421, DOI 10.1093/aje/kwq444
   Kozumplik O, 2011, PSYCHIAT DANUB, V23, P84
   Krishnan V, 2010, AM J PSYCHIAT, V167, P1305, DOI 10.1176/appi.ajp.2009.10030434
   Laborde JE, 2013, P R HEALTH SCI J, V32, P132
   Lasic D, 2014, PSYCHIAT DANUB, V26, P214
   Lawlor DA, 2011, J INTERN MED, V269, P525, DOI 10.1111/j.1365-2796.2011.02343.x
   Levitan RD, 2012, J CLIN PSYCHIAT, V73, P1119, DOI 10.4088/JCP.11m07394
   Liu CS, 2014, CNS NEUROL DISORD-DR, V13, P1693
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Mansur RB, 2015, NEUROSCI BIOBEHAV R, V52, P89, DOI 10.1016/j.neubiorev.2014.12.017
   McCaffery JM, 2003, PSYCHOSOM MED, V65, P490, DOI 10.1097/01.PSY.0000041545.52924.82
   McElroy SL, 2004, J CLIN PSYCHIAT, V65, P634
   McEwen BS, 2007, PHYSIOL REV, V87, P873, DOI 10.1152/physrev.00041.2006
   Mezuk B, 2015, PSYCHOSOM MED, V77, P559, DOI 10.1097/PSY.0000000000000182
   Molyneaux E, 2014, OBSTET GYNECOL, V123, P857, DOI 10.1097/AOG.0000000000000170
   Murabito JM, 2013, OBESITY, V21, P1713, DOI 10.1002/oby.20130
   Nestler EJ, 2002, NEURON, V34, P13, DOI 10.1016/S0896-6273(02)00653-0
   Noh JW, 2015, BMC PUBLIC HEALTH, V15, DOI 10.1186/s12889-015-1663-z
   NOPPA H, 1981, J PSYCHOSOM RES, V25, P83, DOI 10.1016/0022-3999(81)90094-5
   Oladeji BD, 2013, CURR PSYCHIAT REP, V15, DOI 10.1007/s11920-013-0390-3
   Pace TWW, 2009, ANN NY ACAD SCI, V1179, P86, DOI 10.1111/j.1749-6632.2009.04984.x
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Petry NM, 2008, PSYCHOSOM MED, V70, P288, DOI 10.1097/PSY.0b013e3181651651
   Pjetri E, 2012, CURR OPIN CLIN NUTR, V15, P330, DOI 10.1097/MCO.0b013e3283546fd3
   Portela A, 2010, NAT BIOTECHNOL, V28, P1057, DOI 10.1038/nbt.1685
   Preiss K, 2013, OBES REV, V14, P906, DOI 10.1111/obr.12052
   Pulkki-Råback L, 2009, HEALTH PSYCHOL, V28, P108, DOI 10.1037/a0012646
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Rethorst CD, 2014, J CLIN PSYCHIAT, V75, pE1428, DOI 10.4088/JCP.14m09009
   Ribeiro RP, 2015, REV LAT-AM ENFERM, V23, P435
   Richards D, 2011, CLIN PSYCHOL REV, V31, P1117, DOI 10.1016/j.cpr.2011.07.004
   Rivera M, 2012, MOL PSYCHIATR, V17, P604, DOI 10.1038/mp.2011.45
   Roberts RE, 2000, AM J EPIDEMIOL, V152, P163, DOI 10.1093/aje/152.2.163
   Roberts RE, 2003, INT J OBESITY, V27, P514, DOI 10.1038/sj.ijo.0802204
   Roriz-Cruz M, 2007, J AM GERIATR SOC, V55, P374, DOI 10.1111/j.1532-5415.2007.01068.x
   ROSS CE, 1994, J HEALTH SOC BEHAV, V35, P63, DOI 10.2307/2137335
   Rottenberg J, 2014, PSYCHOSOM MED, V76, P122, DOI 10.1097/PSY.0000000000000028
   Samaan Z, 2013, MOL PSYCHIATR, V18, P1281, DOI 10.1038/mp.2012.160
   Samaan Z, 2008, J PSYCHOSOM RES, V65, P103, DOI 10.1016/j.jpsychores.2008.06.008
   Samaan Z, 2015, J CLIN PSYCHIAT, V76, pE1611, DOI 10.4088/JCP.14m09720
   Schmitz N, 2016, MOL PSYCHIATR, V21, P1726, DOI 10.1038/mp.2016.7
   Silarova B, 2015, J PSYCHOSOM RES, V78, P391, DOI 10.1016/j.jpsychores.2015.02.010
   Singh M, 2014, FRONT PSYCHOL, V5, DOI 10.3389/fpsyg.2014.00925
   Soczynska JK, 2011, NEUROMOL MED, V13, P93, DOI 10.1007/s12017-010-8140-8
   Stunkard AJ, 2003, BIOL PSYCHIAT, V54, P330, DOI 10.1016/S0006-3223(03)00608-5
   Taylor VH, 2010, J OBES, V2010, DOI 10.1155/2010/748048
   Trief PM, 2014, OBESITY, V22, P2532, DOI 10.1002/oby.20916
   Tsankova N, 2007, NAT REV NEUROSCI, V8, P355, DOI 10.1038/nrn2132
   Tsigos C, 2002, J PSYCHOSOM RES, V53, P865, DOI 10.1016/S0022-3999(02)00429-4
   van Dijk SJ, 2015, INT J OBESITY, V39, P85, DOI 10.1038/ijo.2014.34
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vancampfort D, 2015, DEPRESS ANXIETY, V32, P763, DOI 10.1002/da.22387
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vanhala M, 2009, ACTA PSYCHIAT SCAND, V119, P137, DOI 10.1111/j.1600-0447.2008.01283.x
   Wong ML, 2001, NAT REV NEUROSCI, V2, P343, DOI 10.1038/35072566
   World Health Organization, 2020, DEPRESSION
   Zhao G, 2009, INT J OBESITY, V33, P257, DOI 10.1038/ijo.2008.268
   Zheng YL, 2014, PLOS ONE, V9, DOI [10.1371/journal.pone.0109765, 10.1371/journal.pone.0093624]
NR 96
TC 31
Z9 32
U1 6
U2 35
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD FEB 12
PY 2022
VL 14
IS 2
AR e22153
DI 10.7759/cureus.22153
PG 10
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA ZD4DV
UT WOS:000758151000009
PM 35308733
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sachinidis, A
   Doumas, M
   Imprialos, K
   Stavropoulos, K
   Katsimardou, A
   Athyros, VG
AF Sachinidis, Alexandros
   Doumas, Michael
   Imprialos, Konstantinos
   Stavropoulos, Konstantinos
   Katsimardou, Alexandra
   Athyros, Vasilios G.
TI Dysmetabolic Iron Overload in Metabolic Syndrome
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Serum ferritin; dysmetabolic iron overload syndrome; metabolic syndrome;
   insuline resistance; type two diabetes; arterial hypertension
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE SYNDROME;
   CORONARY-HEART-DISEASE; SERUM FERRITIN; HEPATIC IRON; OXIDATIVE STRESS;
   HYPOGONADOTROPIC HYPOGONADISM; NONALCOHOLIC STEATOHEPATITIS;
   PHENOTYPIC-EXPRESSION; THYROID-FUNCTION
AB Background: We sought to determine the association of dysmetabolic iron overload syndrome (DIOS) with metabolic syndrome (MetS).
   Methods: Several studies have shown that DIOS is associated with Mets, mainly through the pathogenesis of its components: type 2 diabetes mellitus (T2DM), essential hypertension, non-alcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (POS).
   Results: Serum ferritin levels increase proportionally according to the degree of insulin resistance (IR) and the number of components of Mets. Moreover, DIOS predicts the onset of T2DM and NAFLD. Dysregulation of iron metabolism in DIOS is due to a multifactorial and dynamic process triggered by an unhealthy diet, facilitated by environmental and genetic cofactors, and resulting in a bidirectional relation between the liver and visceral adipose tissue (VAT). Iron removal combined with a healthy diet improved both insulin sensitivity and beta-cell function, but had no significant effect on blood glucose; however, phlebotomy therapy might be considered with conflicting results.
   Conclusion: Iron overload is closely associated with metabolic syndrome and its components; however, it remains under-appreciated in everyday clinical practice. Diet and lifestyle modification offer some clinical benefit; however, it is not adequate for successful management of the disease. The results of phlebotomy remain controversial, underlying the necessity of further efforts in this field.
C1 [Sachinidis, Alexandros; Doumas, Michael; Imprialos, Konstantinos; Stavropoulos, Konstantinos; Katsimardou, Alexandra; Athyros, Vasilios G.] Aristotle Univ Thessaloniki, Hippocrat Hosp, Dept Internal Med, Med Sch,Propaedeut 2, Thessaloniki, Greece.
   [Doumas, Michael; Imprialos, Konstantinos] Georgetown Univ, Washington, DC 20057 USA.
   [Doumas, Michael; Imprialos, Konstantinos] VAMC, Washington, DC USA.
   [Doumas, Michael; Imprialos, Konstantinos] George Washington Univ, Washington, DC USA.
C3 Aristotle University of Thessaloniki; Georgetown University; George
   Washington University
RP Athyros, VG (corresponding author), Aristotle Univ Thessaloniki, Dept Internal Med, Hippocrat Hosp, Med Sch, Thessaloniki, Greece.
EM vathyros@gmail.com
RI Athyros, V.G./H-5328-2019; Stavropoulos, Konstantinos/H-8910-2019
OI Imprialos, Konstantinos/0000-0003-0379-0522; Athyros,
   Vasilios/0000-0002-0882-8676; Doumas, Michael/0000-0002-7269-8044;
   SACHINIDIS, ALEXANDROS/0000-0002-5233-9204
CR Adams LA, 2005, GASTROENTEROLOGY, V129, P113, DOI 10.1053/j.gastro.2005.04.014
   Adams LA, 2015, HEPATOLOGY, V61, P1555, DOI 10.1002/hep.27662
   Adams PC, 2011, J HEPATOL, V55, P453, DOI 10.1016/j.jhep.2011.02.010
   Aigner E, 2010, EUR J CLIN INVEST, V40, P155, DOI 10.1111/j.1365-2362.2009.02238.x
   Aigner E, 2008, GASTROENTEROLOGY, V135, P680, DOI 10.1053/j.gastro.2008.04.007
   Aigner E, 2008, AM J CLIN NUTR, V87, P1374, DOI 10.1093/ajcn/87.5.1374
   Aigner E, 2015, WORLD J HEPATOL, V7, P177, DOI 10.4254/wjh.v7.i2.177
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Martínez-García MA, 2009, DIABETES CARE, V32, P1525, DOI 10.2337/dc09-0420
   Aso Y, 2010, DIABETES RES CLIN PR, V90, P250, DOI 10.1016/j.diabres.2010.09.008
   Barisani D, 2008, J HEPATOL, V49, P123, DOI 10.1016/j.jhep.2008.03.011
   Bastemir M, 2007, SWISS MED WKLY, V137, P431
   Beaton MD, 2013, ALIMENT PHARM THER, V37, P720, DOI 10.1111/apt.12255
   Bhowmick SK, 2007, J NATL MED ASSOC, V99, P773
   Botella-Carretero JI, 2006, DIABETES CARE, V29, P2556, DOI 10.2337/dc06-1655
   Bozzini C, 2005, DIABETES CARE, V28, P2061, DOI 10.2337/diacare.28.8.2061
   Bugianesi E, 2004, HEPATOLOGY, V39, P179, DOI 10.1002/hep.20023
   Chitturi S, 2002, HEPATOLOGY, V36, P142, DOI 10.1053/jhep.2002.33892
   Dallalio G, 2006, BLOOD, V107, P2702, DOI 10.1182/blood-2005-07-2854
   Danesh J, 1999, CIRCULATION, V99, P852, DOI 10.1161/01.CIR.99.7.852
   Datz C, 2013, EUR J CLIN INVEST, V43, P215, DOI 10.1111/eci.12032
   Deugnier Y, 2017, PRESSE MED, V46, pE306, DOI 10.1016/j.lpm.2017.05.036
   Dhindsa S, 2016, CLIN ENDOCRINOL, V85, P772, DOI 10.1111/cen.13130
   Dongiovanni P, 2008, AM J PATHOL, V172, P738, DOI 10.2353/ajpath.2008.070097
   Dongiovanni P, 2011, J HEPATOL, V55, P920, DOI 10.1016/j.jhep.2011.05.008
   Dubern B, 2006, INT J PEDIATR OBES, V1, P77, DOI 10.1080/17477160600569594
   Facchini FS, 2002, GASTROENTEROLOGY, V122, P931, DOI 10.1053/gast.2002.32403
   Fargion S, 2001, AM J GASTROENTEROL, V96, P2448, DOI 10.1111/j.1572-0241.2001.04052.x
   Fernández-Real JM, 2005, CLIN CHEM, V51, P1201, DOI 10.1373/clinchem.2004.046847
   Fernández-Real JM, 1998, DIABETES CARE, V21, P62, DOI 10.2337/diacare.21.1.62
   Fernández-Real JM, 2002, DIABETES, V51, P1000, DOI 10.2337/diabetes.51.4.1000
   Fernández-Real JM, 2007, DIABETES CARE, V30, P616, DOI 10.2337/dc06-1581
   Fierbinteanu-Braticevici Carmen, 2002, Rom J Intern Med, V40, P81
   Ford ES, 1999, DIABETES CARE, V22, P1978, DOI 10.2337/diacare.22.12.1978
   Fumeron F, 2006, DIABETES CARE, V29, P2090, DOI 10.2337/dc06-0093
   Gabrielsen JS, 2012, J CLIN INVEST, V122, P3529, DOI 10.1172/JCI44421
   Galan P, 2006, PUBLIC HEALTH NUTR, V9, P70, DOI 10.1079/PHN2005826
   Gandon Y, 2004, LANCET, V363, P357, DOI 10.1016/S0140-6736(04)15436-6
   Ganz T, 2006, AM J PHYSIOL-GASTR L, V290, pG199, DOI 10.1152/ajpgi.00412.2005
   Gao Y, 2015, J CLIN INVEST, V125, P3681, DOI 10.1172/JCI81860
   Gautier A, 2011, EUR J ENDOCRINOL, V165, P339, DOI 10.1530/EJE-11-0215
   George DK, 1998, GASTROENTEROLOGY, V114, P311, DOI 10.1016/S0016-5085(98)70482-2
   Green A, 2006, METABOLISM, V55, P1042, DOI 10.1016/j.metabol.2006.03.015
   Han LL, 2014, MOL NUTR FOOD RES, V58, P2189, DOI 10.1002/mnfr.201400088
   Handa P, 2016, AM J PHYSIOL-GASTR L, V310, pG117, DOI 10.1152/ajpgi.00246.2015
   Hentze MW, 2004, CELL, V117, P285, DOI 10.1016/S0092-8674(04)00343-5
   Hernaez R, 2011, J HEPATOL, V55, P1079, DOI 10.1016/j.jhep.2011.02.013
   Houschyar KS, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-54
   Hua NW, 2001, BRIT J NUTR, V86, P515, DOI 10.1079/BJN2001421
   Iwasaki T, 2005, DIABETES CARE, V28, P2486, DOI 10.2337/diacare.28.10.2486
   Jézéquel C, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0128530
   Jiang R, 2004, JAMA-J AM MED ASSOC, V291, P711, DOI 10.1001/jama.291.6.711
   Kim CW, 2012, METABOLISM, V61, P1182, DOI 10.1016/j.metabol.2012.01.007
   Kowdley KV, 2012, HEPATOLOGY, V55, P77, DOI 10.1002/hep.24706
   Ku BJ, 2009, DIS MARKERS, V27, P303, DOI [10.1155/2009/931082, 10.3233/DMA-2009-0676]
   Lainé F, 2005, J HEPATOL, V43, P1055, DOI 10.1016/j.jhep.2005.05.027
   Lainé F, 2004, HEPATOLOGY, V39, P1639, DOI 10.1002/hep.20219
   Lainé F, 2006, GASTROENTEROLOGY, V131, P2028, DOI 10.1053/j.gastro.2006.10.046
   Laine F, 2017, HEPATOLOGY, V65, P465, DOI 10.1002/hep.28856
   Lao TT, 2001, DIABETIC MED, V18, P218, DOI 10.1046/j.1464-5491.2001.00453.x
   Lapenna D, 2007, FREE RADICAL BIO MED, V42, P492, DOI 10.1016/j.freeradbiomed.2006.11.014
   Lee TS, 1999, CIRCULATION, V99, P1222, DOI 10.1161/01.CIR.99.9.1222
   Luque-Ramírez M, 2007, DIABETES CARE, V30, P2309, DOI 10.2337/dc07-0642
   Fernández-Real JM, 2008, DIABETES, V57, P1918, DOI 10.2337/db08-0041
   Mendler MH, 1999, GASTROENTEROLOGY, V117, P1155, DOI 10.1016/S0016-5085(99)70401-4
   Michalaki MA, 2006, THYROID, V16, P73, DOI 10.1089/thy.2006.16.73
   Nelson JE, 2012, HEPATOLOGY, V56, P1730, DOI 10.1002/hep.25856
   Piperno A, 2004, LIVER INT, V24, P471, DOI 10.1111/j.1478-3231.2004.0988.x
   Piperno A, 2002, J HYPERTENS, V20, P1513, DOI 10.1097/00004872-200208000-00013
   Powell LW, 2016, LANCET, V388, P706, DOI 10.1016/S0140-6736(15)01315-X
   Ramakrishnan U, 2002, AM J CLIN NUTR, V76, P1256, DOI 10.1093/ajcn/76.6.1256
   Rametta R, 2016, LIVER INT, V36, P1540, DOI 10.1111/liv.13124
   Roblin X, 2003, GASTROEN CLIN BIOL, V27, P1079
   Ruivard M, 2009, J HEPATOL, V50, P1219, DOI 10.1016/j.jhep.2009.01.029
   Rumberger JM, 2004, DIABETES, V53, P2535, DOI 10.2337/diabetes.53.10.2535
   Silva MCP, 2010, EUR J EPIDEMIOL, V25, P643, DOI 10.1007/s10654-010-9489-6
   Sonnweber T, 2012, J NUTR BIOCHEM, V23, P1600, DOI 10.1016/j.jnutbio.2011.10.013
   Sorrentino P, 2009, J HEPATOL, V50, P351, DOI 10.1016/j.jhep.2008.09.011
   Stichel H, 2000, HORM RES, V54, P14, DOI 10.1159/000053224
   Sullivan JL, 2007, EXP BIOL MED, V232, P1014, DOI 10.3181/0703-MR-54
   SULLIVAN JL, 1981, LANCET, V1, P1293
   Sutti S, 2014, HEPATOLOGY, V59, P886, DOI 10.1002/hep.26749
   Theurl I, 2008, BLOOD, V111, P2392, DOI 10.1182/blood-2007-05-090019
   Valenti L, 2003, DIGEST LIVER DIS, V35, P172, DOI 10.1016/S1590-8658(03)00025-2
   Valenti L, 2007, AM J GASTROENTEROL, V102, P1251, DOI 10.1111/j.1572-0241.2007.01192.x
   Valenti L, 2014, WORLD J GASTROENTERO, V20, P3002, DOI 10.3748/wjg.v20.i11.3002
   Valenti L, 2010, J HEPATOL, V53, P927, DOI 10.1016/j.jhep.2010.05.023
   Valenti L, 2010, GASTROENTEROLOGY, V138, P905, DOI 10.1053/j.gastro.2009.11.013
   van der A DL, 2006, EUR J CLIN INVEST, V36, P682, DOI 10.1111/j.1365-2362.2006.01711.x
   Weiss G, 2005, NEW ENGL J MED, V352, P1011, DOI 10.1056/NEJMra041809
   Wood RJ, 2004, AGEING RES REV, V3, P355, DOI 10.1016/j.arr.2004.04.002
   Wrede CE, 2006, EUR J ENDOCRINOL, V154, P333, DOI 10.1530/eje.1.02083
   Zacharski LR, 2007, JAMA-J AM MED ASSOC, V297, P603, DOI 10.1001/jama.297.6.603
   Zimmermann MB, 2008, INT J OBESITY, V32, P1098, DOI 10.1038/ijo.2008.43
   Zoller H, 2001, GASTROENTEROLOGY, V120, P1412, DOI 10.1053/gast.2001.24033
NR 96
TC 46
Z9 50
U1 0
U2 18
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2020
VL 26
IS 10
BP 1019
EP 1024
DI 10.2174/1381612826666200130090703
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA LK7ZQ
UT WOS:000531080500005
PM 32000639
DA 2025-06-11
ER

PT J
AU Zambon, A
   Pauletto, P
   Crepaldi, G
AF Zambon, A
   Pauletto, P
   Crepaldi, G
TI Review article: the metabolic syndrome - a chronic cardiovascular
   inflammatory condition
SO ALIMENTARY PHARMACOLOGY & THERAPEUTICS
LA English
DT Review
ID C-REACTIVE PROTEIN; INSULIN-RESISTANCE SYNDROME; ENDOTHELIAL
   DYSFUNCTION; DISEASE; LDL; ATHEROSCLEROSIS; LIPOPROTEINS; CELLS; RISK;
   MEN
AB The atherosclerotic process is regulated by inflammatory mechanisms, which also appear to be involved in the modulation of insulin-resistance, a key player in the pathogenesis of the metabolic syndrome (MS). The interaction between components of the clinical phenotype of the MS with its biological phenotype (insulin resistance, dyslipidaemia, etc.) contributes to the development of a pro-inflammatory state characterized by an increased oxidative stress (i.e. oxidized lipoproteins) and a chronic, subclinical vascular inflammation, as also suggested by the increased C reactive protein (CRP) concentration found in patients with MS. The subclinical inflammatory state peculiar of the MS modulates the atherosclerotic process at different stages, resulting in: (i) endothelial dysfunction and increased expression of endothelial adhesion molecules; (ii) an enhanced recruitment of monocytes within the arterial wall, in the early stages of the atherosclerotic process; leading to (iii) the formation of an unstable atherosclerotic plaque, rich in inflammatory cells, which is the culprit lesion in the vast majority of both coronary and cerebrovascular events observed in with MS.
C1 Univ Padua, Dept Med & Surg Sci, Padua, Italy.
   Univ Padua, Dept Clin & Expt Med, Padua, Italy.
C3 University of Padua; University of Padua
RP Univ Padua Polyclin, Dept Med & Surg Sci, Med Clin 1, Via Giustiniani 2, I-35128 Padua, Italy.
EM alberto.zambon@unipd.it
RI Zambon, Alberto/J-2122-2012
CR AUSTIN MA, 1988, JAMA-J AM MED ASSOC, V260, P1917
   Barzilay JI, 2001, DIABETES, V50, P2384, DOI 10.2337/diabetes.50.10.2384
   Bonora E, 2003, INT J OBESITY, V27, P1283, DOI 10.1038/sj.ijo.0802381
   CHAIT A, 1993, AM J MED, V94, P350, DOI 10.1016/0002-9343(93)90144-E
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Colomé C, 2000, ATHEROSCLEROSIS, V149, P295, DOI 10.1016/S0021-9150(99)00338-X
   Doi H, 2000, CIRCULATION, V102, P670, DOI 10.1161/01.CIR.102.6.670
   Faggin E, 2002, J AM COLL CARDIOL, V40, P1059, DOI 10.1016/S0735-1097(02)02116-2
   FALK E, 1995, CIRCULATION, V92, P2033, DOI 10.1161/01.CIR.92.8.2033
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Ford ES, 2003, ATHEROSCLEROSIS, V168, P351, DOI 10.1016/S0021-9150(03)00134-5
   JUHANVAGUE I, 1993, ARTERIOSCLER THROMB, V13, P1865, DOI 10.1161/01.ATV.13.12.1865
   Libby P, 2002, NATURE, V420, P868, DOI 10.1161/ATVBAHA.108.179705
   Ridker PM, 2003, CIRCULATION, V107, P363, DOI 10.1161/01.CIR.0000053730.47739.3C
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Sigurdardottir V, 2002, J INTERN MED, V252, P440, DOI 10.1046/j.1365-2796.2002.01054.x
   STEVENSON KL, 1988, METABOLISM, V37, P125
   Vakkilainen J, 2000, CIRCULATION, V102, P716, DOI 10.1161/01.CIR.102.7.716
   Yudkin JS, 1999, ARTERIOSCL THROM VAS, V19, P972, DOI 10.1161/01.ATV.19.4.972
NR 19
TC 48
Z9 53
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-2813
EI 1365-2036
J9 ALIMENT PHARM THER
JI Aliment. Pharmacol. Ther.
PD NOV
PY 2005
VL 22
SU 2
BP 20
EP 23
DI 10.1111/j.1365-2036.2005.02589.x
PG 4
WC Gastroenterology & Hepatology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Pharmacology & Pharmacy
GA 982GU
UT WOS:000233146900005
PM 16225466
OA Bronze
DA 2025-06-11
ER

PT J
AU Kim, J
   Kang, S
   Hong, H
   Joo, M
   Kang, H
AF Kim, Jeonghyeon
   Kang, Seamon
   Hong, Haeryun
   Joo, Mingyu
   Kang, Hyunsik
TI A Non-Randomized Combined Program of Walking and Low-Load Resistance
   Exercise Improves Cognitive Function and Cardiometabolic Risk Factors in
   Community-Dwelling Elderly Women
SO HEALTHCARE
LA English
DT Article
DE exercise intervention; cognitive decline; cardiometabolic risk factors;
   functional fitness
ID METABOLIC SYNDROME; OLDER-ADULTS; KOREAN VERSION; STRENGTH; IMPAIRMENT;
   DEMENTIA; TRIALS
AB Background: This study examines whether changes in cardiometabolic risk factors, functional fitness, and depressive symptoms following a six-month exercise intervention were associated with cognitive function in Korean women aged 65 years and older. Methods: A non-randomized study design was used to compare post-intervention changes in measured variables between control (n = 30) and exercise (n = 30) groups. The exercise intervention consisted of three days of low-load resistance exercise and two days of walking. Cognitive function and depressive symptoms were assessed with the Korean version of the Mini-Mental State Examination and the Korean version of the Geriatric Depression Scale, respectively. Functional fitness was measured using a senior fitness test battery. Results: The exercise group showed a significant improvement in cognitive function (p < 0.001) in conjunction with significant decreases in blood glucose (p = 0.052), triglycerides (p = 0.011), insulin (p = 0.002), tumor necrosis factor-alpha (p = 0.043), and depressive symptoms (p = 0.006) and an increase in interleukin-10 (p = 0.037), compared with the control group. Multivariate stepwise regression showed that changes in depressive symptoms (p < 0.001), insulin resistance (p < 0.001), and upper body muscle strength (p = 0.003) were positively associated with cognitive function. Conclusion: A six-month exercise intervention consisting of walking and low-load/high-repetition elastic band resistance exercise has the potential to improve cognitive function, as well as physical function and cardiometabolic risk factors, and to decrease depressive symptoms in older women.
C1 [Kim, Jeonghyeon; Kang, Seamon; Hong, Haeryun; Joo, Mingyu; Kang, Hyunsik] Sungkyunkwan Univ, Coll Sport Sci, Suwon 16419, South Korea.
C3 Sungkyunkwan University (SKKU)
RP Kang, H (corresponding author), Sungkyunkwan Univ, Coll Sport Sci, Suwon 16419, South Korea.
EM hkang@skku.edu
OI KANG, HYUNSIK/0000-0002-8611-1873
FU National Research Foundation - Korean government [NRF-2020R1A2C1009365]
FX This study was supported by a National Research Foundation grant funded
   by the Korean government (NRF-2020R1A2C1009365).
CR Aagaard P, 2010, SCAND J MED SCI SPOR, V20, P49, DOI 10.1111/j.1600-0838.2009.01084.x
   An KY, 2020, EPIDEMIOL HEALTH, V42, DOI 10.4178/epih.e2020066
   Bac JN, 2004, J PSYCHOSOM RES, V57, P297, DOI 10.1016/j.jpsychores.2004.01.004
   Campos-Peña V, 2017, ANTIOXID REDOX SIGN, V26, P542, DOI 10.1089/ars.2016.6768
   Chase JAD, 2017, J AGING PHYS ACTIV, V25, P149, DOI 10.1123/japa.2016-0040
   Colado JC, 2008, J STRENGTH COND RES, V22, P1441, DOI 10.1519/JSC.0b013e31817ae67a
   Ernst C, 2006, J PSYCHIATR NEUROSCI, V31, P84
   Fornaro M, 2017, INT REV PSYCHIATR, V29, P425, DOI 10.1080/09540261.2017.1299695
   Galán-Arroyo C, 2022, HEALTHCARE-BASEL, V10, DOI 10.3390/healthcare10020181
   Guitar NA, 2018, AGEING RES REV, V47, P159, DOI 10.1016/j.arr.2018.07.009
   Jin Y, 2019, J SPORT SCI MED, V18, P399
   Kim M, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16091491
   Klimova B, 2017, CLIN INTERV AGING, V12, P903, DOI 10.2147/CIA.S132963
   Kwak Cheol-Jin, 2016, J Phys Ther Sci, V28, P3189
   Lachman ME, 2006, J AGING PHYS ACTIV, V14, P59, DOI 10.1123/japa.14.1.59
   Lavie CJ, 2019, CIRC RES, V124, P799, DOI 10.1161/CIRCRESAHA.118.312669
   Teixeira CVL, 2012, ARCH GERONTOL GERIAT, V54, P175, DOI 10.1016/j.archger.2011.02.014
   Liu CJ, 2010, ARCH PHYS MED REHAB, V91, P1471, DOI 10.1016/j.apmr.2010.06.001
   Marquez Patricio V, 2016, Cerebrum, V2016
   Martínez-Velilla N, 2019, JAMA INTERN MED, V179, P28, DOI 10.1001/jamainternmed.2018.4869
   Mcleod JC, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00645
   Melchiorri G, 2011, J ELECTROMYOGR KINES, V21, P954, DOI 10.1016/j.jelekin.2011.07.015
   Minhas PS, 2021, NATURE, V590, P122, DOI 10.1038/s41586-020-03160-0
   Mortimer JA, 2019, NEUROLOGY, V92, P362, DOI 10.1212/WNL.0000000000006935
   Northey JM, 2018, BRIT J SPORT MED, V52, P154, DOI 10.1136/bjsports-2016-096587
   Orssatto LBR, 2018, EXP GERONTOL, V106, P232, DOI 10.1016/j.exger.2018.03.011
   PARK JH, 1990, INT J GERIATR PSYCH, V5, P381, DOI 10.1002/gps.930050606
   Patten RK, 2021, BMC PUBLIC HEALTH, V21, DOI 10.1186/s12889-021-12280-9
   Peng TC, 2020, CLIN NUTR, V39, P2695, DOI 10.1016/j.clnu.2019.12.014
   Ribeiro AS, 2018, J STRENGTH COND RES, V32, P545, DOI 10.1519/JSC.0000000000002326
   Rikli RE, 2013, GERONTOLOGIST, V53, P255, DOI 10.1093/geront/gns071
   Sleiman SF, 2016, ELIFE, V5, DOI 10.7554/eLife.15092
   Snowden M, 2011, J AM GERIATR SOC, V59, P704, DOI 10.1111/j.1532-5415.2011.03323.x
   Stewart KJ, 2005, AM J PREV MED, V28, P9, DOI 10.1016/j.amepre.2004.09.006
   Tasci G, 2019, PSYCHIAT CLIN PSYCH, V29, P137, DOI 10.1080/24750573.2018.1426159
   United Nations Department of Economic and Social Affairs Population Division., 2019, World Population Ageing 2019: Highlights, DOI DOI 10.18356/9DF3CAED-EN
   van de Rest O, 2014, MECH AGEING DEV, V136, P85, DOI 10.1016/j.mad.2013.12.005
   Wang XH, 2021, BMC ENDOCR DISORD, V21, DOI 10.1186/s12902-021-00705-w
   Yaffe K, 2011, ARCH NEUROL-CHICAGO, V68, P631, DOI 10.1001/archneurol.2011.82
   Yates KF, 2012, ARTERIOSCL THROM VAS, V32, P2060, DOI 10.1161/ATVBAHA.112.252759
   Zhang YX, 2020, GERIATR NURS, V41, P261, DOI 10.1016/j.gerinurse.2019.10.006
   Zotcheva E, 2022, SPORTS MED, V52, P1689, DOI 10.1007/s40279-021-01608-5
NR 42
TC 2
Z9 2
U1 1
U2 8
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD OCT
PY 2022
VL 10
IS 10
AR 2106
DI 10.3390/healthcare10102106
PG 12
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA 5R1GY
UT WOS:000874267700001
PM 36292553
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Penninx, BWJH
AF Penninx, Brenda W. J. H.
TI Depression and cardiovascular disease: Epidemiological evidence on their
   linking mechanisms
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Depression; Cardiovascular; Lifestyle; Metabolic syndrome; Inflammation;
   Cortisol; Cardiac autonomic control; Epidemiology
ID HEART-RATE-VARIABILITY; C-REACTIVE PROTEIN; CORTISOL AWAKENING RESPONSE;
   METABOLIC SYNDROME; MAJOR DEPRESSION; ANTIDEPRESSANT MEDICATION;
   MENTAL-DISORDERS; ANXIETY NESDA; META-ANALYSIS; MYOCARDIAL-INFARCTION
AB Depression's burden of disease goes beyond functioning and quality of life and extends to somatic health. Results from longitudinal cohort studies converge in illustrating that major depressive disorder (MDD) subsequently increases the risk of cardiovascular morbidity and mortality with about 80%. The impact of MDD on cardiovascular health may be partly explained by mediating mechanisms such as unhealthy lifestyle (smoking, excessive alcohol use, physical inactivity, unhealthy diet, therapy non-compliance) and unfavorable pathophysiological disturbances (autonomic, HPA-axis, metabolic and immuno-inflammatory dysregulations). A summary of the literature findings as well as relevant results from the large-scale Netherlands Study of Depression and Anxiety (N =2981) are presented. Persons with MDD have significantly worse lifestyles as well as more pathophysiological disturbances as compared to healthy controls. Some of these differences seem to be specific for (typical versus 'atypical', or antidepressant treated versus drug-naive) subgroups of MDD patients. Alternative explanations are also present, namely undetected confounding, iatrogenic effects or 'third factors' such as genetics. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
   [Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, Neurosci Campus Amsterdam, Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam
RP Penninx, BWJH (corresponding author), Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, AJ Ernststr 1187, NL-1081 HL Amsterdam, Netherlands.
EM b.penninx@vumc.nl
RI Penninx, Brenda/S-7627-2017
FU VICI grant (NWO) [91811602]
FX Penninx was supported through a VICI grant (NWO grant 91811602).
CR Alexopoulos GS, 2006, BIOL PSYCHIAT, V60, P1304, DOI 10.1016/j.biopsych.2006.09.006
   ANDA RF, 1990, JAMA-J AM MED ASSOC, V264, P1541, DOI 10.1001/jama.264.12.1541
   Bartels Meike, 2012, Frontiers in Genetics, V3, P4, DOI 10.3389/fgene.2012.00004
   Batelaan NM, 2016, BRIT J PSYCHIAT, V208, P223, DOI 10.1192/bjp.bp.114.156554
   Bomhof-Roordink H, 2015, J PSYCHOSOM RES, V78, P332, DOI 10.1016/j.jpsychores.2015.02.009
   Bonaccorso S, 2002, J CLIN PSYCHOPHARM, V22, P86, DOI 10.1097/00004714-200202000-00014
   Bradley SM, 2015, TRENDS CARDIOVAS MED, V25, P614, DOI 10.1016/j.tcm.2015.02.002
   Cesari M, 2003, CIRCULATION, V108, P2317, DOI 10.1161/01.CIR.0000097109.90783.FC
   Cherbuin N, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2015-008853
   Chida Y, 2008, NAT CLIN PRACT ONCOL, V5, P466, DOI 10.1038/ncponc1134
   Cohen BE, 2015, AM J HYPERTENS, V28, P1295, DOI 10.1093/ajh/hpv047
   Cuijpers P, 2014, AM J PSYCHIAT, V171, P453, DOI 10.1176/appi.ajp.2013.13030325
   de Geus EJC, 2006, PSYCHOSOM MED, V68, P185, DOI 10.1097/01.psy.0000208628.90274.bc
   de Kloet ER, 2005, NAT REV NEUROSCI, V6, P463, DOI 10.1038/nrn1683
   De Moor MHM, 2008, ARCH GEN PSYCHIAT, V65, P897, DOI 10.1001/archpsyc.65.8.897
   Dekker JM, 2000, CIRCULATION, V102, P1239, DOI 10.1161/01.CIR.102.11.1239
   DiMatteo MR, 2000, ARCH INTERN MED, V160, P2101, DOI 10.1001/archinte.160.14.2101
   Dong JY, 2012, STROKE, V43, P32, DOI 10.1161/STROKEAHA.111.630871
   Dortland AKBV, 2010, ACTA PSYCHIAT SCAND, V122, P30, DOI 10.1111/j.1600-0447.2010.01565.x
   Dortland AKBV, 2013, PSYCHOSOM MED, V75, P83, DOI 10.1097/PSY.0b013e318274d30f
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Doyle F, 2015, PSYCHOSOM MED, V77, P419, DOI 10.1097/PSY.0000000000000174
   Druss BG, 2001, ARCH GEN PSYCHIAT, V58, P565, DOI 10.1001/archpsyc.58.6.565
   Eyre HA, 2016, PHARMACOPSYCHIATRY, V49, P85, DOI 10.1055/s-0042-103159
   Girshkin L, 2014, PSYCHONEUROENDOCRINO, V49, P187, DOI 10.1016/j.psyneuen.2014.07.013
   Glassman AH, 2002, JAMA-J AM MED ASSOC, V288, P701, DOI 10.1001/jama.288.6.701
   Grande G, 2012, ANN BEHAV MED, V43, P299, DOI 10.1007/s12160-011-9339-0
   Hamer M, 2012, J CLIN ENDOCR METAB, V97, pE29, DOI 10.1210/jc.2011-2132
   Hamer M, 2011, EUR HEART J, V32, P437, DOI 10.1093/eurheartj/ehq438
   Hamer M, 2010, ATHEROSCLEROSIS, V210, P209, DOI 10.1016/j.atherosclerosis.2010.01.038
   Hannestad J, 2011, NEUROPSYCHOPHARMACOL, V36, P2452, DOI 10.1038/npp.2011.132
   Hinkelmann K, 2012, PSYCHONEUROENDOCRINO, V37, P685, DOI 10.1016/j.psyneuen.2011.08.012
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Hu M.X., 2016, PSYCHOSOM MED
   Jokela M, 2014, J BEHAV MED, V37, P881, DOI 10.1007/s10865-013-9548-z
   Kaptoge S, 2010, LANCET, V375, P132, DOI 10.1016/S0140-6736(09)61717-7
   Kemp AH, 2014, AM J PSYCHIAT, V171, P1328, DOI 10.1176/appi.ajp.2014.13121605
   Kemp AH, 2010, BIOL PSYCHIAT, V67, P1067, DOI [10.1016/j.biopsych.2009.12.012, 10.1016/j.biopsych.2009.11.019]
   Knorr U, 2010, PSYCHONEUROENDOCRINO, V35, P1275, DOI 10.1016/j.psyneuen.2010.04.001
   Kuehl LK, 2015, PSYCHONEUROENDOCRINO, V51, P365, DOI 10.1016/j.psyneuen.2014.09.012
   Kumari M, 2011, J CLIN ENDOCR METAB, V96, P1478, DOI 10.1210/jc.2010-2137
   Lamers F, 2016, BRIT J PSYCHIAT, V208, P62, DOI 10.1192/bjp.bp.114.153098
   Lamers F, 2013, MOL PSYCHIATR, V18, P692, DOI 10.1038/mp.2012.144
   Lamers F, 2012, PSYCHOL MED, V42, P2083, DOI 10.1017/S0033291712000141
   Lamers F, 2012, BRIT J PSYCHIAT, V201, P143, DOI 10.1192/bjp.bp.111.098079
   Lamers F, 2010, J CLIN PSYCHIAT, V71, P1582, DOI 10.4088/JCP.09m05398blu
   Lasserre AM, 2014, JAMA PSYCHIAT, V71, P880, DOI 10.1001/jamapsychiatry.2014.411
   Licht CMM, 2015, PSYCHOSOM MED, V77, P279, DOI 10.1097/PSY.0000000000000165
   Licht CMM, 2013, J CLIN ENDOCR METAB, V98, P2484, DOI 10.1210/jc.2012-3104
   Licht CMM, 2012, NEUROPSYCHOPHARMACOL, V37, P2487, DOI 10.1038/npp.2012.107
   Licht CMM, 2010, BIOL PSYCHIAT, V68, P861, DOI 10.1016/j.biopsych.2010.06.032
   Licht CMM, 2010, J CLIN ENDOCR METAB, V95, P2458, DOI 10.1210/jc.2009-2801
   Licht CMM, 2009, HYPERTENSION, V53, P631, DOI 10.1161/HYPERTENSIONAHA.108.126698
   Licht CMM, 2008, ARCH GEN PSYCHIAT, V65, P1358, DOI 10.1001/archpsyc.65.12.1358
   Liu Y, 2012, J AFFECT DISORDERS, V139, P230, DOI 10.1016/j.jad.2011.08.003
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Meng L, 2012, J HYPERTENS, V30, P842, DOI 10.1097/HJH.0b013e32835080b7
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Milaneschi Y, 2016, MOL PSYCHIATR, V21, P516, DOI 10.1038/mp.2015.86
   Milaneschi Y, 2014, MOL PSYCHIATR, V19, P444, DOI 10.1038/mp.2013.36
   Milaneschi Y., 2016, BIOL PSYCHIAT
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Mulle JG, 2013, PROG CARDIOVASC DIS, V55, P557, DOI 10.1016/j.pcad.2013.03.005
   Nelson JC, 1997, AM J PSYCHIAT, V154, P1497, DOI 10.1176/ajp.154.11.1497
   Nicholson A, 2006, EUR HEART J, V27, P2763, DOI 10.1093/eurheartj/ehl338
   Noordam R, 2016, PSYCHOL MED, V46, P1239, DOI 10.1017/S0033291715002779
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Paz G, 2010, INT J CLIN PRACT, V64, P1808, DOI 10.1111/j.1742-1241.2010.02536.x
   Penninx B.W., 1998, HEALTH PSYCHOL, V5, P1
   Penninx BWJH, 2008, INT J METH PSYCH RES, V17, P121, DOI 10.1002/mpr.256
   Penninx BWJH, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-129
   Penninx BWJH, 2000, AM J PSYCHIAT, V157, P715, DOI 10.1176/appi.ajp.157.5.715
   Porges SW, 2001, INT J PSYCHOPHYSIOL, V42, P123, DOI 10.1016/S0167-8760(01)00162-3
   Rottenberg J, 2007, J AFFECT DISORDERS, V103, P173, DOI 10.1016/j.jad.2007.01.028
   Sanhueza C, 2013, J HUM NUTR DIET, V26, P56, DOI 10.1111/j.1365-277X.2012.01283.x
   Scott KM, 2013, INT J CARDIOL, V168, P5293, DOI 10.1016/j.ijcard.2013.08.012
   Seldenrijk A, 2011, BIOL PSYCHIAT, V69, P795, DOI 10.1016/j.biopsych.2010.12.034
   Seldenrijk A, 2010, J PSYCHOSOM RES, V69, P203, DOI 10.1016/j.jpsychores.2010.01.005
   Shelton RC, 2010, PROG NEUROBIOL, V91, P275, DOI 10.1016/j.pneurobio.2010.04.004
   Silverman MN, 2012, ANN NY ACAD SCI, V1261, P55, DOI 10.1111/j.1749-6632.2012.06633.x
   STEPHENS T, 1988, PREV MED, V17, P35, DOI 10.1016/0091-7435(88)90070-9
   Stetler C, 2011, PSYCHOSOM MED, V73, P114, DOI 10.1097/PSY.0b013e31820ad12b
   Sublette ME, 2012, PSYCHOSOM MED, V74, P668, DOI 10.1097/PSY.0b013e318268de9f
   Sullivan PF, 2002, J AFFECT DISORDERS, V68, P273, DOI 10.1016/S0165-0327(00)00364-5
   Sullivan PF, 1998, AM J PSYCHIAT, V155, P1398, DOI 10.1176/ajp.155.10.1398
   Sumner JA, 2015, CIRCULATION, V132, P251, DOI 10.1161/CIRCULATIONAHA.114.014492
   Taylor CB, 2005, ARCH GEN PSYCHIAT, V62, P792, DOI 10.1001/archpsyc.62.7.792
   Teicher MH, 2013, AM J PSYCHIAT, V170, P1114, DOI 10.1176/appi.ajp.2013.12070957
   Tsuji H, 1996, CIRCULATION, V94, P2850, DOI 10.1161/01.CIR.94.11.2850
   Van der Kooy K, 2007, INT J GERIATR PSYCH, V22, P613, DOI 10.1002/gps.1723
   Van Melle JP, 2007, BRIT J PSYCHIAT, V190, P460, DOI 10.1192/bjp.bp.106.028647
   van Zyl LT, 2008, BIOPSYCHOSOC MED, V2, DOI 10.1186/1751-0759-2-12
   Visser M, 1999, JAMA-J AM MED ASSOC, V282, P2131, DOI 10.1001/jama.282.22.2131
   Vogelzangs N, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.8
   Vogelzangs N, 2014, NEUROPSYCHOPHARMACOL, V39, P1624, DOI 10.1038/npp.2014.9
   Vogelzangs N, 2011, J CLIN PSYCHIAT, V72, P598, DOI 10.4088/JCP.10m06559
   Vogelzangs N, 2010, J CLIN ENDOCR METAB, V95, P4959, DOI 10.1210/jc.2010-0192
   Vreeburg SA, 2010, BRIT J PSYCHIAT, V197, P180, DOI 10.1192/bjp.bp.109.076869
   Vreeburg SA, 2009, ARCH GEN PSYCHIAT, V66, P617, DOI 10.1001/archgenpsychiatry.2009.50
   Walker ER, 2015, JAMA PSYCHIAT, V72, P334, DOI 10.1001/jamapsychiatry.2014.2502
   Whang W, 2009, J AM COLL CARDIOL, V53, P950, DOI 10.1016/j.jacc.2008.10.060
NR 101
TC 346
Z9 374
U1 11
U2 141
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD MAR
PY 2017
VL 74
SI SI
BP 277
EP 286
DI 10.1016/j.neubiorev.2016.07.003
PN B
PG 10
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA EM9AF
UT WOS:000395602500004
PM 27461915
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Kabthymer, RH
   Techane, SN
   Hailemariam, S
   Bekele, YA
   Mekuriaw, B
AF Kabthymer, Robel Hussen
   Techane, Solomon Nega
   Hailemariam, Solomon
   Bekele, Yibeltal Alemu
   Mekuriaw, Birhanie
TI Metabolic syndrome among people with mental illness in sub Saharan
   Africa: Female gender as a factor. A Systematic review and meta-analysis
SO ANNALS OF MEDICINE AND SURGERY
LA English
DT Review
DE Metabolic syndrome; Syndrome x; Low income setting; Mental disorder
ID PREVALENCE; COMPONENTS; DISORDERS; RISK
AB Background: The prevalence of metabolic syndrome among psychiatric patients in developing nations is mounting alarmingly and it is a reason for decreased life expectancy and quality of life of people with mental illness. Although great discrepant epidemiological studies have been carried out in Sub Saharan African countries, there has no systematic review and meta-analysis conducted. Therefore, summarized evidence has a paramount importance for policy makers and health planning. This study aims to estimate the prevalence of metabolic syndrome and to examine the effect of gender on metabolic syndrome among people with mental illness in sub Saharan Africa.
   Method: Systematic literature search was performed using PubMed, CINAHL, Web of science, Global health electronic databases. In addition, gray literatures were retrieved from Google and Google scholar. Two authors independently extracted all the necessary data using a format prepared in Microsoft Excel. Data analysis was done using STATA Version 14 (software). The heterogeneity of the studies was assessed using I(2)test.Randomeffects model was used to estimate pooled prevalence of MetS and its odds ratio. Publication bias was checked using Funnel plot and Egge's test.
   Result: 1306 studies were reviewed and nine studies fulfilling the inclusion criteria were selected for the metaanalysis. The meta-analysis of nine studies that included 1896 participants found a prevalence rate of metabolic syndrome which was performed based on assessment criteria; JIS criteria prevalence 21.11% (95% CI: 17.93-24.29), IDF criteria 23.77% (95% CI: 15.41-32.12) and NCEP ATP-III criteria 21.63% (95% CI: 16.30-26.96). Female gender (AOR = 3.00; 95% CI: 1.98-4.55) was found to have a significant association with metabolic syndrome.
   Conclusion: The prevalence of metabolic syndrome among people with mental illness in sub Saharan Africa is high in various assessment criteria. The likelihood is significantly increased in females than males. Metabolic syndrome increases by three folds among females with mental illness as compared to their counterparts.
C1 [Kabthymer, Robel Hussen; Hailemariam, Solomon] Dilla Univ, Coll Hlth Sci & Med, Sch Publ Hlth, Dilla, Ethiopia.
   [Techane, Solomon Nega] Dilla Univ, Coll Hlth Sci & Med, Sch Med, Dilla, Ethiopia.
   [Mekuriaw, Birhanie] Dilla Univ, Coll Hlth Sci & Med, Dept Psychiat, Dilla, Ethiopia.
   [Bekele, Yibeltal Alemu] Bahir Dar Univ, Coll Hlth Sci & Med, Dept Reprod Hlth, Bahirdar, Ethiopia.
C3 Dilla University; Dilla University; Dilla University; Bahir Dar
   University
RP Kabthymer, RH (corresponding author), Dilla Univ, Coll Hlth Sci & Med, Sch Publ Hlth, Dilla, Ethiopia.
EM robelk@du.edu.et; sola.nega@gmail.com; solomon0917242124@gmail.com;
   yibeltalalemu6@gmail.com; birhanie2013@gmail.com
RI Kabthymer, Robel/AAX-3597-2020
OI kabthymer, robel/0000-0002-6734-0312; Mekuriaw,
   Birhanie/0000-0002-0600-0234; Bekele, Yibeltal/0000-0003-1272-7824
CR Agaba D.C., 2019, BIOMED RES INT, V2019
   Akinlade K.S., 2016, EGYPT J PSYCHIAR, V37, P97
   Asaye S, 2018, DIABETES METAB SYND, V12, P753, DOI 10.1016/j.dsx.2018.04.037
   Attux C, 2007, REV BRAS PSIQUIATR, V29, P346, DOI 10.1590/S1516-44462006005000061
   Beigh SH, 2012, BIOINFORMATION, V8, P613, DOI 10.6026/97320630008613
   Bentley-Lewis R, 2007, NAT CLIN PRACT ENDOC, V3, P696, DOI 10.1038/ncpendmet0616
   Borenstein M, 2010, RES SYNTH METHODS, V1, P97, DOI 10.1002/jrsm.12
   Dallongeville J, 2004, ANN NUTR METAB, V48, P43, DOI 10.1159/000075304
   Hammarsten J, 1998, PROSTATE CANCER P D, V1, P157, DOI 10.1038/sj.pcan.4500221
   Jahan F, 2007, JCPSP-J COLL PHYSICI, V17, P32
   Kim Y, 2018, NUTRIENTS, V10, DOI 10.3390/nu10040390
   Lawani A, 2009, Nigerian J Psychiatric, V7
   Li R, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-2870-y
   Lopuszanska UJ, 2014, ANN AGR ENV MED, V21, P815, DOI 10.5604/12321966.1129939
   Maaroganye K, 2013, AFR J PSYCHIATRY, V16, P414, DOI [10.4314/ajpsy.v16i6.53, http://dx.doi.org/10.4314/ajpsy.v16i6.53]
   Ostovar Rahim, 2017, Electron Physician, V9, P5402, DOI 10.19082/5402
   Owiredu W., 2012, J MED BIOMED SCI, V1
   Page MJ, 2021, BMJ-BRIT MED J, V372, DOI [10.1136/bmj.n71, 10.1136/bmj.n160]
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Pramyothin P, 2010, CURR OPIN ENDOCRINOL, V17, P460, DOI 10.1097/MED.0b013e32833de61c
   Prasad D S, 2012, J Cardiovasc Dis Res, V3, P204, DOI 10.4103/0975-3583.98895
   Robert M.A, 2018, VITAL CAPACITY METAB
   Rücker G, 2008, BMC MED RES METHODOL, V8, DOI 10.1186/1471-2288-8-79
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Saloojee S, 2017, SAJP-S AFR J PSYCHI, V23, DOI 10.4102/sajpsychiatry.v23i0.1089
   Saloojee S, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0149209
   Saloojee S, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/s12888-014-0228-5
   Shea BJ, 2017, BMJ-BRIT MED J, V358, DOI 10.1136/bmj.j4008
   Taking A.W, 2018, SAT SCHWEIZ ARCH TIE, V8, P00
   Teshome T, 2020, DIABETES METAB SYNDR, V13, P569, DOI 10.2147/DMSO.S235379
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vigo D, 2016, LANCET PSYCHIAT, V3, P171, DOI 10.1016/S2215-0366(15)00505-2
   Wells G A., 2014, Appl Eng Agric, V18, P727
   Wild SH, 2011, METABOLIC SYNDROME, 2ND EDITION, P1
   Xu SY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0078270
NR 35
TC 3
Z9 3
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2049-0801
J9 ANN MED SURG
JI Ann. Med. Surg.
PD MAY
PY 2021
VL 65
AR 102351
DI 10.1016/j.amsu.2021.102351
EA MAY 2021
PG 7
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA SU3YP
UT WOS:000663077700004
PM 34007445
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yates, JD
   Aldous, JWF
   Bailey, DP
   Chater, AM
   Mitchell, ACS
   Richards, JC
AF Yates, James D.
   Aldous, Jeffrey W. F.
   Bailey, Daniel P.
   Chater, Angel M.
   Mitchell, Andrew C. S.
   Richards, Joanna C.
TI The Prevalence and Predictors of Hypertension and the Metabolic Syndrome
   in Police Personnel
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE hypertension; metabolic syndrome; stress; sitting time; police
ID BLOOD-PRESSURE; RISK-FACTORS; CARDIOVASCULAR-DISEASE; SEDENTARY
   BEHAVIORS; WAIST CIRCUMFERENCE; PHYSICAL-ACTIVITY; ASSOCIATION;
   OFFICERS; STRESS; VALUES
AB Hypertension and metabolic syndrome (METSYN) are reportedly high in police forces. This may contribute to health deterioration and absenteeism in police personnel. Police forces comprise of staff in 'operational' and 'non-operational' job types but it is not known if job type is associated to hypertension and METSYN prevalence. This study aimed to explore the prevalence of hypertension and METSYN, the factors associated with the risk of hypertension and METSYN, and compare physiological, psychological, and behavioural factors between operational and non-operational police personnel. Cross-sectional data was collected from 77 operational and 60 non-operational police workers. Hypertension and METSYN were prevalent in 60.5% and 20% of operational and 60.0% and 13.6% of non-operational police personnel, respectively (p > 0.05). Operational job type, moderate organisational stress (compared with low stress) and lower high-density lipoprotein cholesterol were associated with lower odds of hypertension, whereas increasing body mass index was associated with increased odds of hypertension (p < 0.05). None of the independent variables were significantly associated with the odds of METSYN. Operational police had several increased cardiometabolic risk markers compared with non-operational police. Given the high prevalence of hypertension and METSYN in operational and non-operational personnel, occupational health interventions are needed for the police and could be informed by the findings of this study.
C1 [Yates, James D.; Aldous, Jeffrey W. F.; Bailey, Daniel P.; Chater, Angel M.; Mitchell, Andrew C. S.; Richards, Joanna C.] Univ Bedfordshire, Inst Sport & Phys Act Res, Bedford MK41 9EA, England.
   [Bailey, Daniel P.] Brunel Univ London, Sedentary Behav Hlth & Dis Res Grp, Uxbridge UB8 3PH, Middx, England.
   [Bailey, Daniel P.] Brunel Univ London, Dept Life Sci, Div Sport Hlth & Exercise Sci, Uxbridge UB8 3PH, Middx, England.
C3 University of Bedfordshire; Brunel University; Brunel University
RP Yates, JD; Richards, JC (corresponding author), Univ Bedfordshire, Inst Sport & Phys Act Res, Bedford MK41 9EA, England.
EM james.yates8@btinternet.com; jeffrey.aldous@beds.ac.uk;
   daniel.bailey@brunel.ac.uk; angel.chater@beds.ac.uk;
   andrew.mitchell@beds.ac.uk; jo.richards@beds.ac.uk
RI Bailey, Daniel/HDL-7697-2022; Aldous, Jeffrey/HMD-8989-2023
OI Aldous, Jeffrey/0000-0002-9159-4646; Chater, Angel
   Marie/0000-0002-9043-2565; Bailey, Daniel/0000-0003-3772-630X; Richards,
   Joanna/0000-0001-8300-3765
FU Office of the Police and Crime Commissioner at Bedfordshire Police
   [NUT14618]
FX This research was funded through support from the Office of the Police
   and Crime Commissioner at Bedfordshire Police (grant number NUT14618).
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Baik I, 2008, AM J CLIN NUTR, V87, P1455, DOI 10.1093/ajcn/87.5.1455
   Bailey DP, 2019, AM J PREV MED, V57, P408, DOI 10.1016/j.amepre.2019.04.015
   Beunza JJ, 2007, AM J HYPERTENS, V20, P1156, DOI 10.1016/j.amjhyper.2007.06.007
   BORG GAV, 1982, MED SCI SPORT EXER, V14, P377, DOI 10.1249/00005768-198205000-00012
   Carey RM, 2018, ANN INTERN MED, V168, P351, DOI 10.7326/M17-3203
   Choudhury KN, 2014, VASC HEALTH RISK MAN, V10, P327, DOI 10.2147/VHRM.S61019
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   Dalton M, 2003, J INTERN MED, V254, P555, DOI 10.1111/j.1365-2796.2003.01229.x
   Dick G., 2001, INT J PUBLIC SECTOR, V14, P111, DOI [DOI 10.1108/09513550110387336, 10.1108/09513550110387336]
   Edwardson CL, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034916
   Elliott P, 2014, ENVIRON RES, V134, P280, DOI 10.1016/j.envres.2014.07.025
   Elliott-Davies M., 2016, The Police Journal:Theory, Practice and Principles, V89, P93
   Fess E.E., 1992, GRIP STRENGTH, V2nd ed.
   Gibson R, 2018, EUR J NUTR, V57, P2913, DOI 10.1007/s00394-017-1562-4
   Hao G, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.00719
   Home Office, 2021, POL WORKF ENGL WAL 0
   Houdmont J., 2016, POL FED ENGL WAL OFF
   Huai PC, 2013, HYPERTENSION, V62, P1021, DOI 10.1161/HYPERTENSIONAHA.113.01965
   Kales SN, 2009, AM J HYPERTENS, V22, P11, DOI 10.1038/ajh.2008.296
   Koegelenberg CFN, 2013, SAMJ S AFR MED J, V103, P52, DOI [10.7196/SAMJ.6197, 10.7196/samj.6197]
   Lee PH, 2015, SPORTS MED, V45, P867, DOI 10.1007/s40279-015-0322-y
   Leischik R, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0133113
   Lifestyles Team NHS Digital, 2018, HLTH SURVEY ENGLAND
   Loveday B., 2015, Police services Leadership and management perspectives, P115, DOI DOI 10.1007/978-3-319-16568-4_
   Magnavita N, 2018, INT ARCH OCC ENV HEA, V91, P377, DOI 10.1007/s00420-018-1290-y
   Marshall AL, 2010, MED SCI SPORT EXER, V42, P1094, DOI 10.1249/MSS.0b013e3181c5ec18
   McCreary DR, 2017, POLICE PRACT RES, V18, P612, DOI 10.1080/15614263.2017.1363965
   Meneses-Gaya C, 2010, ALCOHOL CLIN EXP RES, V34, P1417, DOI 10.1111/j.1530-0277.2010.01225.x
   Rankinen T, 2007, MED SCI SPORT EXER, V39, P1687, DOI 10.1249/mss.0b013e31812e527f
   Sykes K., 2004, Physiotherapy, V90, P183, DOI [10.1016/j.physio.2004.03.008, DOI 10.1016/J.PHYSIO.2004.03.008]
   Taylor SA, 2011, INT J PEDIATR OBES, V6, pE307, DOI 10.3109/17477166.2011.575149
   Tharkar Shabana, 2008, J Assoc Physicians India, V56, P845
   Thayyil J, 2012, N AM J MED SCI, V4, P630, DOI 10.4103/1947-2714.104313
   Thompson MM., 2006, Int J Stress Manag, V13, P494, DOI [DOI 10.1037/1072-5245.13.4.494, 10.1037/1072-5245.13.4.494]
   Thornton G., 1991, Detectives Or Clerks?: An Examination of the Work of Detectives
   Tsang RCC, 2005, HONG KONG PHYSIOTHER, V23, P6, DOI 10.1016/S1013-7025(09)70053-3
   van Vliet-Ostaptchouk JV, 2014, BMC ENDOCR DISORD, V14, DOI 10.1186/1472-6823-14-9
   Violanti JM, 2009, ARCH ENVIRON OCCUP H, V64, P194, DOI 10.1080/19338240903241259
   Wirth MD, 2014, J OCCUP ENVIRON MED, V56, P986, DOI 10.1097/JOM.0000000000000213
   Wu YF, 1998, INT J EPIDEMIOL, V27, P49, DOI 10.1093/ije/27.1.49
   Zhang JY, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000017306
   Zimmerman FH, 2012, CARDIOL REV, V20, P159, DOI 10.1097/CRD.0b013e318248d631
NR 43
TC 8
Z9 9
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD JUL
PY 2021
VL 18
IS 13
AR 6728
DI 10.3390/ijerph18136728
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA TG0QU
UT WOS:000671118800001
PM 34206524
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Goldman-Mellor, SJ
   Caspi, A
   Harrington, H
   Hogan, S
   Nada-Raja, S
   Poulton, R
   Moffitt, TE
AF Goldman-Mellor, Sidra J.
   Caspi, Avshalom
   Harrington, HonaLee
   Hogan, Sean
   Nada-Raja, Shyamala
   Poulton, Richie
   Moffitt, Terrie E.
TI Suicide Attempt in Young People A Signal for Long-term Health Care and
   Social Needs
SO JAMA PSYCHIATRY
LA English
DT Article
ID RISK-FACTORS; MENTAL-HEALTH; ADOLESCENT HEALTH; FOLLOW-UP; PREVALENCE;
   OUTCOMES; BEHAVIORS; MORTALITY; ENGLAND; CHILD
AB IMPORTANCE Suicidal behavior has increased since the onset of the global recession, a trend that may have long-term health and social implications.
   OBJECTIVE To test whether suicide attempts among young people signal increased risk for later poor health and social functioning above and beyond a preexisting psychiatric disorder.
   DESIGN We followed up a cohort of young people and assessed multiple aspects of their health and social functioning as they approached midlife. Outcomes among individuals who had self-reported a suicide attempt up through age 24 years (young suicide attempters) were compared with those who reported no attempt through age 24 years (nonattempters). Psychiatric history and social class were controlled for.
   SETTING AND PARTICIPANTS The population-representative Dunedin Multidisciplinary Health and Development Study, which involved 1037 birth cohort members comprising 91 young suicide attempters and 946 nonattempters, 95% of whom were followed up to age 38 years.
   MAIN OUTCOMES AND MEASURES Outcomes were selected to represent significant individual and societal costs: mental health, physical health, harm toward others, and need for support.
   RESULTS As adults approaching midlife, young suicide attempters were significantly more likely to have persistent mental health problems (eg, depression, substance dependence, and additional suicide attempts) compared with nonattempters. They were also more likely to have physical health problems (eg, metabolic syndrome and elevated inflammation). They engaged in more violence (eg, violent crime and intimate partner abuse) and needed more social support (eg, long-term welfare receipt and unemployment). Furthermore, they reported being lonelier and less satisfied with their lives. These associations remained after adjustment for youth psychiatric diagnoses and social class.
   CONCLUSIONS AND RELEVANCE Many young suicide attempters remain vulnerable to costly health and social problems into midlife. As rates of suicidal behavior rise with the continuing global recession, additional suicide prevention efforts and long-term monitoring and after-care services are needed.
C1 [Goldman-Mellor, Sidra J.] Univ N Carolina, Ctr Dev Sci, Chapel Hill, NC USA.
   [Goldman-Mellor, Sidra J.; Caspi, Avshalom; Harrington, HonaLee; Moffitt, Terrie E.] Duke Univ, Dept Psychol & Neurosci, Durham, NC 27708 USA.
   [Goldman-Mellor, Sidra J.; Caspi, Avshalom; Harrington, HonaLee; Moffitt, Terrie E.] Duke Univ, Inst Genome Sci & Policy, Durham, NC 27708 USA.
   [Goldman-Mellor, Sidra J.; Caspi, Avshalom; Harrington, HonaLee; Moffitt, Terrie E.] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27708 USA.
   [Caspi, Avshalom; Moffitt, Terrie E.] Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London WC2R 2LS, England.
   [Hogan, Sean; Poulton, Richie] Univ Otago, Dunedin Multidisciplinary Hlth & Dev Res Unit, Dept Prevent & Social Med, Dunedin, New Zealand.
   [Nada-Raja, Shyamala] Univ Otago, Dept Prevent & Social Med, Dunedin, New Zealand.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   Duke University; Duke University; Duke University; University of London;
   King's College London; University of Otago; University of Otago
RP Moffitt, TE (corresponding author), Duke Univ, Dept Psychol & Neurosci, 2020 W Main St,Ste 201,Campus Box 104410, Durham, NC 27708 USA.
EM tem11@duke.edu
RI caspi, avshalom/AAJ-5874-2020; Poulton, Richie/H-2795-2014; Moffitt,
   Terrie/D-5295-2011
OI Moffitt, Terrie/0000-0002-8589-6760
FU New Zealand Health Research Council; US National Institute of Aging
   [AG032282]; UK Medical Research Council [MR/K00381X]; National Institute
   of Child Health and Human Development through the Center for
   Developmental Science, University of North Carolina at Chapel Hill
   [T32-HD07376]; Jacobs Foundation; MRC [MR/K00381X/1] Funding Source:
   UKRI
FX The Dunedin Multidisciplinary Health and Development Research Unit is
   supported by the New Zealand Health Research Council. This study was
   supported by grant AG032282 from the US National Institute of Aging,
   grant MR/K00381X from the UK Medical Research Council, and a
   postdoctoral fellowship provided by the National Institute of Child
   Health and Human Development (T32-HD07376) through the Center for
   Developmental Science, University of North Carolina at Chapel Hill (Dr
   Goldman-Mellor). Additional support was provided by the Jacobs
   Foundation. No other disclosures were reported.
CR [Anonymous], NEET RAT YOUTH OECD
   [Anonymous], DIAGNOSTIC INTERVIEW
   [Anonymous], FULL EMPLOYMENT WHEN
   [Anonymous], EMPL ISS GOV REP
   [Anonymous], 2005, SUICIDE RATES NZ EXP
   [Anonymous], NZ J ED STUD
   [Anonymous], 2007, Why people die by suicide
   Barr B, 2012, BMJ-BRIT MED J, V345, DOI 10.1136/bmj.e5142
   Beautrais A.L., 2000, UNMET NEED PSYCHIAT
   Beautrais AL, 2003, AUST NZ J PSYCHIAT, V37, P595, DOI 10.1046/j.1440-1614.2003.01236.x
   Beautrais AL, 2000, AUST NZ J PSYCHIAT, V34, P420, DOI 10.1080/j.1440-1614.2000.00691.x
   Borges G, 2006, PSYCHOL MED, V36, P1747, DOI 10.1017/S0033291706008786
   Brown GK, 2000, J CONSULT CLIN PSYCH, V68, P371, DOI 10.1037//0022-006X.68.3.371
   Caspi A, 1996, INT J METHOD PSYCH, V6, P101, DOI 10.1002/(SICI)1234-988X(199607)6:2<101::AID-MPR156>3.3.CO;2-E
   Catalano R, 2011, ANNU REV PUBL HEALTH, V32, P431, DOI 10.1146/annurev-publhealth-031210-101146
   Crosby Alex E., 2011, Morbidity and Mortality Weekly Report, V60, P1
   De Vogli R, 2013, J EPIDEMIOL COMMUN H, V67, DOI 10.1136/jech-2012-201607
   Evans E, 2005, SUICIDE LIFE-THREAT, V35, P239, DOI 10.1521/suli.2005.35.3.239
   Fergusson DM, 2005, PSYCHOL MED, V35, P983, DOI 10.1017/S0033291704004167
   Fleischmann A, 2008, B WORLD HEALTH ORGAN, V86, P703, DOI 10.2471/BLT.07.046995
   Goffman E., 1963, STIGMA NOTES MANAGEM
   Goldsmith S.K., 2002, REDUCING SUICIDE NAT
   Haukka J, 2008, AM J EPIDEMIOL, V167, P1155, DOI 10.1093/aje/kwn017
   HAWTON K, 1985, BRIT J PSYCHIAT, V146, P486, DOI 10.1192/bjp.146.5.486
   Hawton K, 2012, LANCET, V379, P2373, DOI 10.1016/S0140-6736(12)60322-5
   Joiner TE, 2005, J ABNORM PSYCHOL, V114, P291, DOI 10.1037/0021-843X.114.2.291
   Kentikelenis A, 2011, LANCET, V378, P1457, DOI 10.1016/S0140-6736(11)61556-0
   Kerr DCR, 2011, PSYCHOL MED, V41, P759, DOI 10.1017/S0033291710001182
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Libby P, 2002, CIRCULATION, V105, P1135, DOI 10.1161/hc0902.104353
   Link BG, 2001, ANNU REV SOCIOL, V27, P363, DOI 10.1146/annurev.soc.27.1.363
   Nada-Raja S, 2004, SUICIDE LIFE-THREAT, V34, P177, DOI 10.1521/suli.34.2.177.32781
   Nock MK, 2008, BRIT J PSYCHIAT, V192, P98, DOI 10.1192/bjp.bp.107.040113
   Nock MK, 2006, J ABNORM PSYCHOL, V115, P616, DOI 10.1037/0021-843X.115.3.616
   Nock MK, 2013, JAMA PSYCHIAT, V70, P300, DOI 10.1001/2013.jamapsychiatry.55
   Pajonk FG, 2005, EUR PSYCHIAT, V20, P115, DOI 10.1016/j.eurpsy.2004.10.003
   Patel V, 2007, LANCET, V369, P1302, DOI 10.1016/S0140-6736(07)60368-7
   Reeves A, 2012, LANCET, V380, P1813, DOI 10.1016/S0140-6736(12)61910-2
   Robins L., 1995, DIAGNOSTIC INTERVIEW
   Robins L.N., 1989, DIAGNOSTIC INTERVIEW
   Sawyer SM, 2012, LANCET, V379, P1630, DOI 10.1016/S0140-6736(12)60072-5
   Shaffer D, 1996, ARCH GEN PSYCHIAT, V53, P339
   Spirito A, 2006, ANNU REV CLIN PSYCHO, V2, P237, DOI 10.1146/annurev.clinpsy.2.022305.095323
   Tejedor MC, 1999, ACTA PSYCHIAT SCAND, V100, P205, DOI 10.1111/j.1600-0447.1999.tb10847.x
   Van Orden KA, 2010, PSYCHOL REV, V117, P575, DOI 10.1037/a0018697
   Weaver J, 2013, J SOC HIST, V46, P757, DOI 10.1093/jsh/shs109
   While D, 2012, LANCET, V379, P1005, DOI 10.1016/S0140-6736(11)61712-1
NR 47
TC 262
Z9 283
U1 2
U2 54
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-622X
EI 2168-6238
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD FEB
PY 2014
VL 71
IS 2
BP 119
EP 127
DI 10.1001/jamapsychiatry.2013.2803
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AA8UN
UT WOS:000331370600003
PM 24306041
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hashem-Dabaghian, F
   Ghods, R
   Shojaii, A
   Abdi, L
   Campos-Toimil, M
   Yousefsani, BS
AF Hashem-Dabaghian, Fataneh
   Ghods, Roshanak
   Shojaii, Asie
   Abdi, Leila
   Campos-Toimil, Manuel
   Yousefsani, Bahareh Sadat
TI Rhus coriaria L., a new candidate for controlling metabolic
   syndrome: a systematic review
SO JOURNAL OF PHARMACY AND PHARMACOLOGY
LA English
DT Review
DE metabolic syndrome; Rhus coriaria L; diabetes mellitus; hypertension;
   hyperlipidaemia; insulin resistance syndrome
ID OXIDATIVE STRESS; PHARMACOLOGICAL-PROPERTIES; INSULIN-RESISTANCE;
   DOUBLE-BLIND; SUMAC; EXTRACT; CHOLESTEROL; POWDER; PLANT; HYPERTENSION
AB Objectives Rhus coriaria L. (RC) is a deciduous shrub with several pharmacological activities. Evidence of the effects of RC on weight, hyperlipidaemia, hypertension and diabetes mellitus have been presented in this study. Books, thesis and internet-based resources such as PubMed, Web of Science, Scopus, EMBASE, Cochrane, Ovid and Google Scholar were searched for the English, Arabic and Persian literature from 1966 to 2020 (December). The keywords were Rhus coriaria L., Sumac, metabolic syndrome and all its medical conditions (hyperlipidaemia, hypertension, obesity and diabetes mellitus). The inclusion criteria were full-text animal and human studies conducted on RC to evaluate its efficacy on any components of metabolic syndrome (MetS). Jadad scale was used to assess the quality of evidence.
   Key findings Reviewing 23 relevant studies demonstrated that RC is able to decrease the level of blood glucose, glycated haemoglobin, serum insulin and insulin resistance. Studies on hyperlipidaemia and obesity have very contradicting results, and there is no definite conclusion on the effect of RC on lipid profile. However, the hypotensive and effect of RC was confirmed in the existing studies.
   Summary According to the literature, RC can be considered as a promising curative candidate for MetS. However, further studies with larger sample size and higher methodological quality are needed.
C1 [Hashem-Dabaghian, Fataneh; Ghods, Roshanak; Shojaii, Asie; Abdi, Leila; Yousefsani, Bahareh Sadat] Iran Univ Med Sci, Res Inst Islamic & Complementary Med, Tehran 1114733311, Iran.
   [Hashem-Dabaghian, Fataneh; Ghods, Roshanak; Shojaii, Asie; Abdi, Leila] Iran Univ Med Sci, Sch Persian Med, Metab Syndrome Res Grp, Tehran, Iran.
   [Campos-Toimil, Manuel] Univ Santiago de Compostela, CIMUS, Physiol & Pharmacol Chron Dis FIFAEC, Santiago De Compostela, Spain.
   [Yousefsani, Bahareh Sadat] Iran Univ Med Sci, Sch Persian Med, Tehran, Iran.
C3 Iran University of Medical Sciences; Iran University of Medical
   Sciences; Universidade de Santiago de Compostela; Iran University of
   Medical Sciences
RP Yousefsani, BS (corresponding author), Iran Univ Med Sci, Res Inst Islamic & Complementary Med, Tehran 1114733311, Iran.
EM yousefsani.b@iums.ac.ir
RI yousefsani, bahare/U-6824-2018; Ghods, Roshanak/D-5424-2018;
   Hashem-Dabaghian, Fataneh/AFA-8635-2022; Shojaii, Asie/T-2733-2019;
   Campos-Toimil, Manuel/C-6164-2011
OI Shojaii, Asie/0000-0002-9093-5525; Campos-Toimil,
   Manuel/0000-0003-3674-3749
CR Abu-Reidah I., 2014, JORDAN J BIOL SCI, V7, P233, DOI 10.12816/0008245
   Abu-Reidah IM, 2015, FOOD CHEM, V166, P179, DOI 10.1016/j.foodchem.2014.06.011
   Ahangarpour A, 2017, RES PHARM SCI, V12, P416, DOI 10.4103/1735-5362.213987
   Ahangarpour A, 2014, WORLD J MENS HEALTH, V32, P151, DOI 10.5534/wjmh.2014.32.3.151
   Akaberi M, 2016, PHYTOTHER RES, V30, P540, DOI 10.1002/ptr.5570
   Akbari-Fakhrabadi M, 2018, COMPLEMENT THER MED, V40, P8, DOI 10.1016/j.ctim.2018.07.001
   Al-Hamdany NF, 2019, Rafidain J Sci, V28, P61, DOI [10.33899/rjs.2019.163302, DOI 10.33899/RJS.2019.163302]
   Anwer T, 2013, ACTA POL PHARM, V70, P861
   Ardalani H, 2016, RSC ADV, V6, P11507, DOI 10.1039/c5ra22840a
   Asgarpanah J, 2014, RES J PHARMACOGN, V1, P47
   Asgary S, 2018, J AM COLL NUTR, V37, P286, DOI 10.1080/07315724.2017.1394237
   Berger VW, 2009, REV RECENT CLIN TRIA, V4, P79, DOI 10.2174/157488709788186021
   Candan F, 2004, PHYTOTHER RES, V18, P84, DOI 10.1002/ptr.1228
   Darnavandi RD, 2019, INT J ENDOCRINOL MET, V17, DOI 10.5812/ijem.70744
   Djakpo O, 2010, PHYTOTHER RES, V24, P1739, DOI 10.1002/ptr.3215
   Dludla PV, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010023
   Dogan A, 2016, PHARM BIOL, V54, P2092, DOI 10.3109/13880209.2016.1145702
   Fatahi Ardakani M. R., 2016, Iranian Journal of Diabetes and Obesity, V8, P172
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Fuster V, 2011, HURSTS HEART, V13th
   Gaballu FA, 2015, PHARM BIOL, V53, P1104, DOI 10.3109/13880209.2014.960943
   Gertsch J, 2008, P NATL ACAD SCI USA, V105, P9099, DOI 10.1073/pnas.0803601105
   Ghorbanian B., 2017, CMJA, V7, P1805
   Giancarlo S, 2006, NAT PROD RES, V20, P882, DOI 10.1080/14786410500520186
   Gök HN, 2020, J FOOD SCI, V85, P3220, DOI 10.1111/1750-3841.15438
   Golzadeh M, 2012, S AFR J ANIM SCI, V42, P398, DOI 10.4314/sajas.v42i4.8
   Graf BL, 2010, CURR OPIN INVEST DR, V11, P1107
   Gurbuz Y, 2017, J ANIM PHYSIOL AN N, V101, P1316, DOI 10.1111/jpn.12652
   Hajmohammadi Z., 2016, IRAN J MED SCI, V41, pS10
   Hajmohammadi Z, 2018, J INTEGR MED-JIM, V16, P45, DOI 10.1016/j.joim.2017.12.007
   Hariri N, 2020, PHYTOTHER RES, V34, P3041, DOI 10.1002/ptr.6737
   Hassani FV, 2016, N-S ARCH PHARMACOL, V389, P931, DOI 10.1007/s00210-016-1256-0
   Heydari M., 2019, Shiraz E Med J, V20, pe87301, DOI [10.5812/semj.87301, DOI 10.5812/SEMJ.87301]
   Hollander JM, 2008, J AM DIET ASSOC, V108, P495, DOI 10.1016/j.jada.2007.12.007
   Hosseini A, 2015, J ENDOCRINOL INVEST, V38, P1147, DOI 10.1007/s40618-015-0313-8
   Hosseini Siyar S, 2017, J Anim Prod Res, V6, P89, DOI [10.22124/AR.2017.2223, DOI 10.22124/AR.2017.2223]
   Hui WS, 2010, EUR J EPIDEMIOL, V25, P375, DOI 10.1007/s10654-010-9459-z
   Jadad AR, 1996, CONTROL CLIN TRIALS, V17, P1, DOI 10.1016/0197-2456(95)00134-4
   Jamshidi A.H., 2020, medicine, V19, P17, DOI [10.29252/jmp.19.75.17, DOI 10.29252/JMP.19.75.17]
   Ju SY, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000008491
   Kenari HM, 2021, J PHARMACOPUNCT, V24, P14, DOI 10.3831/KPI.2021.24.1.14
   Kiani Amir, 2017, Toxicology and Environmental Health Sciences, V9, P244, DOI 10.1007/s13530-017-0327-z
   Kim MH, 2004, J KOREAN MED SCI, V19, P195, DOI 10.3346/jkms.2004.19.2.195
   Kooti Wesam, 2016, Electron Physician, V8, P1832, DOI 10.19082/1832
   Kosar M, 2007, FOOD CHEM, V103, P952, DOI 10.1016/j.foodchem.2006.09.049
   Lee KH, 2011, NUTR RES PRACT, V5, P28, DOI 10.4162/nrp.2011.5.1.28
   Mavlyanov S. M., 1997, Chemistry of Natural Compounds, V33, P209, DOI 10.1007/BF02291544
   Mirhadi K., 2011, Advances in Environmental Biology, V5, P2077
   Mohammadi S, 2010, DARU, V18, P270
   Mollazadeh H, 2016, IRAN J BASIC MED SCI, V19, P1258, DOI 10.22038/ijbms.2016.7906
   Morvaridzadeh M, 2020, CYTOKINE, V135, DOI 10.1016/j.cyto.2020.155224
   Payab M, 2020, PHYTOTHER RES, V34, P526, DOI 10.1002/ptr.6547
   Picot J, 2012, HEALTH TECHNOL ASSES, V16, pIX, DOI 10.3310/hta16190
   Pourahmad J, 2010, FOOD CHEM TOXICOL, V48, P854, DOI 10.1016/j.fct.2009.12.021
   Rahideh ST, 2014, J RES MED SCI, V19, P933
   Rains JL, 2011, FREE RADICAL BIO MED, V50, P567, DOI 10.1016/j.freeradbiomed.2010.12.006
   Rayne S, 2007, PLANT FOOD HUM NUTR, V62, P165, DOI 10.1007/s11130-007-0058-4
   Razavi BM, 2014, J ENDOCRINOL INVEST, V37, P1031, DOI 10.1007/s40618-014-0150-1
   Regazzoni L, 2013, J PHARMACEUT BIOMED, V72, P202, DOI 10.1016/j.jpba.2012.08.017
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Rouhi-Boroujeni H., 2016, J Der Pharm Lett, V8, P143
   Sabzghabaee Ali Mohammad, 2014, Med Arch, V68, P308, DOI 10.5455/medarh.2014.68.308-312
   Sakhr K, 2020, HELIYON, V6, DOI 10.1016/j.heliyon.2020.e03207
   Salimi A, 2019, HUM EXP TOXICOL, V38, P1266, DOI 10.1177/0960327119871096
   Salimi Z, 2012, J Birjand Univ Med Sci, V18, P275
   Salimi Zahra, 2015, Indian J Physiol Pharmacol, V59, P87
   Schnack Lauren L, 2017, Recent Pat Biotechnol, V11, P101, DOI 10.2174/1872208311666170227112013
   Setorki M., 2012, J BABOL U MED SCI, V14, P38
   Shabana MM, 2011, PHARMACOGN MAG, V7, P298, DOI 10.4103/0973-1296.90410
   Shabbir A, 2012, J ANIM PLANT SCI, V22, P505
   Shafiei M, 2011, PHARMAZIE, V66, P988, DOI 10.1691/ph.2011.1555
   Shidfar F, 2014, IRAN J PHARM RES, V13, P1249
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Soltani H, 2017, Intern Med Med Invest J, V2, P97, DOI [10.24200/imminv.v2i3.91, DOI 10.24200/IMMINV.V2I3.91]
   Tabeshpour J, 2017, IRAN J BASIC MED SCI, V20, P557, DOI 10.22038/IJBMS.2017.8682
   Tabeshpour J, 2017, PHYTOTHER RES, V31, P819, DOI 10.1002/ptr.5805
   Wu LY, 2004, P NATL ACAD SCI USA, V101, P7094, DOI 10.1073/pnas.0402004101
NR 77
TC 0
Z9 0
U1 1
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3573
EI 2042-7158
J9 J PHARM PHARMACOL
JI J. Pharm. Pharmacol.
PD JAN
PY 2022
VL 74
IS 1
BP 1
EP 12
DI 10.1093/jpp/rgab120
EA OCT 2021
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA YO6XD
UT WOS:000748080800001
DA 2025-06-11
ER

PT J
AU Teychenne, M
   Ball, K
   Salmon, J
AF Teychenne, Megan
   Ball, Kylie
   Salmon, Jo
TI Sedentary Behavior and Depression Among Adults: A Review
SO INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Review
DE Depression; Mental health; Television; Adult; Internet; Computers
ID TIME PHYSICAL-ACTIVITY; DEPENDENT DIABETES-MELLITUS; TELEVISION VIEWING
   TIME; CORONARY-HEART-DISEASE; LEISURE-TIME; METABOLIC SYNDROME; VIGOROUS
   EXERCISE; INTERNET PARADOX; YOUNG-ADULTS; RISK-FACTORS
AB Background Physically inactive lifestyles and sedentary behaviors (SB) are key contributors to ill health. Although the association between SB (e. g., watching TV/using the computer) and physical health has been well documented, increasing research has focused on the possible link between SB and mental health (e. g., depression).
   Purpose This review aims to investigate the effect of SB on the risk of depression in adults.
   Method A systematic search for original research articles investigating associations between SB and depression in adults was performed using the several electronic data bases.
   Results A total of seven observational and four intervention studies were included in this review. All observational studies found positive associations between SB and risk of depression, while intervention studies showed contradictory results.
   Conclusion Evidence for the relationship between SB and risk of depression in adults is limited by methodological weaknesses. However, on balance, this review suggests that SB is associated with an increased risk of depression. Further studies are needed assessing different types of SB and depression; the interrelationship between physical activity, SB, and depression; causal links between SB and depression; and intervention strategies aimed at reducing SB and their effects on risk of depression.
C1 [Teychenne, Megan; Ball, Kylie; Salmon, Jo] Deakin Univ, Ctr Phys Act & Nutr Res, Sch Exercise & Nutr Sci, Burwood, Vic 3125, Australia.
C3 Deakin University
RP Teychenne, M (corresponding author), Deakin Univ, Ctr Phys Act & Nutr Res, Sch Exercise & Nutr Sci, 221 Burwood Hwy, Burwood, Vic 3125, Australia.
EM mteych@deakin.edu.au
RI Salmon, Jo/X-2630-2019; Ball, Kylie/B-5866-2015; Salmon, Jo/C-1226-2009
OI Salmon, Jo/0000-0002-4734-6354; Teychenne, Megan/0000-0002-7293-8255
CR *AC NIELS CO, 2000, NIELS REP TEL
   Ainsworth BE, 2000, MED SCI SPORT EXER, V32, pS498, DOI 10.1097/00005768-200009001-00009
   Australian Bureau of Statistics, 1998, AUSTR US THEIR TIM
   Azar D., 2008, Mental Health And Physical Activity, V1, P82, DOI DOI 10.1016/J.MHPA.2008.09.004
   Beck A.T., 1978, Beck depression inventory
   BLAIR SN, 1989, JAMA-J AM MED ASSOC, V262, P2395, DOI 10.1001/jama.262.17.2395
   Brosse AL, 2002, SPORTS MED, V32, P741, DOI 10.2165/00007256-200232120-00001
   Brummett BH, 2005, PSYCHOSOM MED, V67, P40, DOI 10.1097/01.psy.0000149257.74854.b7
   Cameron AJ, 2003, MED J AUSTRALIA, V178, P427, DOI 10.5694/j.1326-5377.2003.tb05283.x
   Clark BK, 2009, OBES REV, V10, P7, DOI 10.1111/j.1467-789X.2008.00508.x
   Coakley EH, 1998, INT J OBESITY, V22, P89, DOI 10.1038/sj.ijo.0800549
   *COMM DEP HLTH AG, 1999, NAT HLTH PRIOR AR RE
   DiNardo JE, 1997, Q J ECON, V112, P291, DOI 10.1162/003355397555190
   DITTMAR ML, 1994, J SOC BEHAV PERS, V9, P317
   DOSEMECI M, 1993, CANCER CAUSE CONTROL, V4, P313, DOI 10.1007/BF00051333
   Dunstan DW, 2007, DIABETES CARE, V30, P516, DOI 10.2337/dc06-1996
   Dunstan DW, 2005, DIABETOLOGIA, V48, P2254, DOI 10.1007/s00125-005-1963-4
   Dunstan DW, 2004, DIABETES CARE, V27, P2603, DOI 10.2337/diacare.27.11.2603
   ERIKSSON KF, 1991, DIABETOLOGIA, V34, P891, DOI 10.1007/BF00400196
   Ford ES, 2005, OBES RES, V13, P608, DOI 10.1038/oby.2005.65
   Graves L, 2008, BRIT J SPORT MED, V42, P592
   Greden JF, 2001, J CLIN PSYCHIAT, V62, P5
   Haapanen N, 1997, INT J OBESITY, V21, P288, DOI 10.1038/sj.ijo.0800403
   Hirose K, 1996, JPN J CANCER RES, V87, P1001, DOI 10.1111/j.1349-7006.1996.tb02132.x
   Hu FB, 2003, JAMA-J AM MED ASSOC, V289, P1785, DOI 10.1001/jama.289.14.1785
   Jakes RW, 2003, EUR J CLIN NUTR, V57, P1089, DOI 10.1038/sj.ejcn.1601648
   KLEINKE CL, 1988, J CLIN PSYCHOL, V44, P516, DOI 10.1002/1097-4679(198807)44:4<516::AID-JCLP2270440407>3.0.CO;2-B
   Kraut R, 1998, AM PSYCHOL, V53, P1017, DOI 10.1037/0003-066X.53.9.1017
   Kraut R, 2002, J SOC ISSUES, V58, P49, DOI 10.1111/1540-4560.00248
   Kronenberg F, 2000, ATHEROSCLEROSIS, V153, P433, DOI 10.1016/S0021-9150(00)00426-3
   Lawlor D.A., 2001, BMJ-BRIT MED J, V322, P1, DOI DOI https://doi.org/10.1136/bmj.322.7289.763
   Leon AS, 1997, INT J SPORTS MED, V18, pS208, DOI 10.1055/s-2007-972717
   Lewinsohn P. M., 1974, BEHAV APPROACH DEPRE
   Lotan Meir, 2005, Int J Adolesc Med Health, V17, P23
   Manson JE, 1999, NEW ENGL J MED, V341, P650, DOI 10.1056/NEJM199908263410904
   MANSON JE, 1991, LANCET, V338, P774, DOI 10.1016/0140-6736(91)90664-B
   Moher D, 2001, BMC Med Res Methodol, V1, P2, DOI 10.1186/1471-2288-1-2
   Morgan C, 2003, CYBERPSYCHOL BEHAV, V6, P133, DOI 10.1089/109493103321640329
   MORRIS JN, 1980, LANCET, V2, P1207
   *NAT ASS SPORT PHY, 2003, SPORTS J, V6
   O'Neal HA, 2000, INT J SPORT PSYCHOL, V31, P110
   *OFF NAT STAT, 2006, 2000 2005 TIM US SUR
   Owen N, 2000, Exerc Sport Sci Rev, V28, P153
   Paluska SA, 2000, SPORTS MED, V29, P167, DOI 10.2165/00007256-200029030-00003
   Pan XR, 1997, DIABETES CARE, V20, P537, DOI 10.2337/diacare.20.4.537
   Panagiotakos DB, 2007, ASIA-PAC J PUBLIC HE, V19, P22, DOI 10.1177/101053950701900305
   Paw MJMCA, 2008, SPORTS MED, V38, P781, DOI 10.2165/00007256-200838090-00006
   Penedo FJ, 2005, CURR OPIN PSYCHIATR, V18, P189, DOI 10.1097/00001504-200503000-00013
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Sanchez A, 2008, PREV MED, V46, P196, DOI 10.1016/j.ypmed.2007.10.005
   Sanchez-Villegas A, 2008, MED SCI SPORT EXER, V40, P827, DOI 10.1249/MSS.0b013e31816348b9
   Shaw LH, 2002, CYBERPSYCHOL BEHAV, V5, P517, DOI 10.1089/109493102321018150
   Sidney S, 1996, ANN EPIDEMIOL, V6, P154, DOI 10.1016/1047-2797(95)00135-2
   Singh AS, 2008, OBES REV, V9, P474, DOI 10.1111/j.1467-789X.2008.00475.x
   Sugiyama T, 2008, ANN BEHAV MED, V35, P245, DOI 10.1007/s12160-008-9017-z
   Sugiyama T, 2007, AM J PREV MED, V33, P444, DOI 10.1016/j.amepre.2007.07.035
   Teychenne M, 2008, PREV MED, V46, P397, DOI 10.1016/j.ypmed.2008.01.009
   Thomée S, 2007, COMPUT HUM BEHAV, V23, P1300, DOI 10.1016/j.chb.2004.12.007
   *US BUR LAB STAT, 2008, AM TIM US SURV 2007
   von Elm E, 2007, LANCET, V370, P1453, DOI 10.1016/S0140-6736(07)61602-X
NR 60
TC 350
Z9 397
U1 3
U2 100
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1070-5503
EI 1532-7558
J9 INT J BEHAV MED
JI Int. J. Behav. Med.
PD DEC
PY 2011
VL 17
IS 4
BP 246
EP 254
DI 10.1007/s12529-010-9075-z
PG 9
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA 762LA
UT WOS:000290478100002
PM 20174982
DA 2025-06-11
ER

PT J
AU Wilson, C
   Nichles, A
   Zmicerevska, N
   Carpenter, JS
   Song, YJC
   McHugh, C
   Hamilton, B
   Hockey, S
   Scott, EM
   Hickie, IB
AF Wilson, Chloe
   Nichles, Alissa
   Zmicerevska, Natalia
   Carpenter, Joanne Sarah
   Song, Yun Ju Christine
   McHugh, Catherine
   Hamilton, Blake
   Hockey, Samuel
   Scott, Elizabeth M.
   Hickie, Ian B.
TI Effect of an online healthy lifestyle psychoeducation programme to
   improve cardiometabolic outcomes and affective symptoms in youth
   receiving mental health care: study protocol for a pilot clinical trial.
SO BMJ OPEN
LA English
DT Article
DE mental health; child & adolescent psychiatry; depression & mood
   disorders; schizophrenia & psychotic disorders
ID 2ND-GENERATION ANTIPSYCHOTIC MEDICATIONS; MAJOR DEPRESSIVE DISORDER;
   SCREENING-TEST ASSIST; PHYSICAL-ACTIVITY; BIPOLAR DISORDER; WEIGHT-GAIN;
   PSYCHOMETRIC EVALUATION; SEDENTARY BEHAVIOR; PREMATURE MORTALITY; EXCESS
   MORTALITY
AB Introduction Worsened cardiometabolic profiles in youth with mental ill health have been associated with a number of modifiable lifestyle risk factors. It is becoming increasingly evident that clinical interventions need to be multimodal in focus to improve mental health symptoms and the physical health symptoms in this already at-risk cohort. Methods and analysis This 12-week pilot clinical trial examines the efficacy, feasibility and acceptability of an adjunctive online psychoeducation programme for improving cardiometabolic risk parameters and affective symptoms in a transdiagnostic sample of at least 44 young people aged 16-25 years presenting for mental healthcare for mood and/or psychotic syndromes (including anxiety, depression, bipolar disorder and psychosis). Individuals will be invited to participate in a pilot clinical trial for a structured online psychoeducation programme incorporating nutritional, physical activity, sleep-wake and healthy lifestyle information, delivered fortnightly over six online modules. Participants will undergo a series of assessments including: (1) self-report and clinician administered assessments determining mental health symptomatology; (2) fasting blood tests to assess cardiometabolic markers (fasting insulin, fasting glucose and blood lipids); (3) anthropometric assessments (height, weight, waist circumference and blood pressure); and (4) sleep-wake behaviours and circadian rhythm assessments. Changes in scores for all cardiometabolic and affective measures will be assessed via paired samples t-tests, and correlations between change scores will be assessed via Pearson's or Spearman's correlations. Feasibility will be assessed via completion rates, and the acceptability of the programme will be assessed via programme satisfaction measures. Ethics and dissemination This pilot clinical trial has been approved by the Sydney Local Health District Research Ethics and Governance Office (X20-0228 & 2020/ETH01201). The results of this pilot clinical trial will be disseminated into the scientific and broader community through peer-reviewed journals, conference presentations, social media and university websites.
C1 [Wilson, Chloe; Nichles, Alissa; Zmicerevska, Natalia; Carpenter, Joanne Sarah; Song, Yun Ju Christine; McHugh, Catherine; Hamilton, Blake; Hockey, Samuel; Scott, Elizabeth M.; Hickie, Ian B.] Univ Sydney, Brain & Mind Ctr, Youth Mental Hlth & Technol Team, Sydney, NSW, Australia.
C3 University of Sydney
RP Wilson, C (corresponding author), Univ Sydney, Brain & Mind Ctr, Youth Mental Hlth & Technol Team, Sydney, NSW, Australia.
EM chloe.wilson@sydney.edu.au
RI Carpenter, Joanne/HZK-3629-2023; Hickie, Ian/K-8975-2015
OI , Chloe/0000-0001-6539-423X; Hockey, Samuel James/0000-0001-8930-6409;
   McHugh, Catherine/0000-0002-4891-4966; Nichles,
   Alissa/0000-0001-6404-7199; Carpenter, Joanne/0000-0002-9766-6700;
   Scott, Elizabeth/0000-0003-3907-0324; Hickie, Ian/0000-0001-8832-9895
FU University of Sydney; National Health & Medical Research Council
   Australia [511921]; Caroline Quinn Research Grant; Liu McCabe Family
   Scholarship
FX This project is an investigator-initiated study, sponsored by the
   University of Sydney and supported by philanthropic funding, for which
   donor(s) are families affected by mental illness who wish to remain
   anonymous. This study was also partially funded by a philanthropic PhD
   scholarship (The Liu McCabe Family Scholarship awarded to CW), a
   National Health & Medical Research Council Australia Fellowship (No.
   511921, awarded to IBH) and a philanthropic fellowship (the Caroline
   Quinn Research Grant awarded to JC).
CR Ali R, 2002, ADDICTION, V97, P1183
   American Psychiatric Association, 2013, Arlington v. FCC, V5
   Andrews G, 2001, AUST NZ J PUBL HEAL, V25, P494, DOI 10.1111/j.1467-842X.2001.tb00310.x
   [Anonymous], 1993, Insomnia: psychological assessment and management
   Arango C, 2009, EUR CHILD ADOLES PSY, V18, P418, DOI 10.1007/s00787-009-0749-5
   Baeza I, 2017, EUR CHILD ADOLES PSY, V26, P35, DOI 10.1007/s00787-016-0866-x
   Bagley C., 2001, INT J ADOLESCENCE YO, V9, P117, DOI [DOI 10.1080/02673843.2001.9747871, 10.1080/02673843.2001.9747871]
   Barker MK, 2018, CLIN NUTR ESPEN, V23, P205, DOI 10.1016/j.clnesp.2017.09.013
   BELL M, 1992, J NERV MENT DIS, V180, P723, DOI 10.1097/00005053-199211000-00007
   Berg KC, 2012, INT J EAT DISORDER, V45, P428, DOI 10.1002/eat.20931
   Berryman C, 2012, J PHYSIOTHER, V58, P273, DOI 10.1016/S1836-9553(12)70133-9
   Bersani FS, 2017, J MENT HEALTH, V26, P271, DOI 10.1080/09638237.2017.1294741
   Booth M, 2000, Res Q Exerc Sport, V71 Suppl 2, P114, DOI 10.1080/02701367.2000.11082794
   Briguglio M, 2020, NEUROPSYCH DIS TREAT, V16, P55, DOI 10.2147/NDT.S229206
   Bush K, 1998, ARCH INTERN MED, V158, P1789, DOI 10.1001/archinte.158.16.1789
   Busner Joan, 2007, Psychiatry (Edgmont), V4, P28
   Callaghan RC, 2014, J PSYCHIATR RES, V48, P102, DOI 10.1016/j.jpsychires.2013.09.014
   Carpenter JS, 1998, J PSYCHOSOM RES, V45, P5, DOI 10.1016/S0022-3999(97)00298-5
   Cheng-Shannon J, 2004, J CHILD ADOL PSYCHOP, V14, P372, DOI 10.1089/1044546042389037
   Chesney E, 2014, WORLD PSYCHIATRY, V13, P153, DOI 10.1002/wps.20128
   Correll CU, 2006, J AM ACAD CHILD PSY, V45, P771, DOI 10.1097/01.chi.0000220851.94392.30
   Correll CU, 2009, JAMA-J AM MED ASSOC, V302, P1765, DOI 10.1001/jama.2009.1549
   Cousins JC, 2011, J PEDIATR PSYCHOL, V36, P969, DOI 10.1093/jpepsy/jsr036
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   Cuijpers P, 2014, AM J PSYCHIAT, V171, P453, DOI 10.1176/appi.ajp.2013.13030325
   De Hert M, 2011, EUR PSYCHIAT, V26, P144, DOI 10.1016/j.eurpsy.2010.09.011
   De Hert M, 2012, CNS DRUGS, V26, P733, DOI 10.2165/11634500-000000000-00000
   De Rosa C, 2017, EXPERT REV NEUROTHER, V17, P667, DOI 10.1080/14737175.2017.1325321
   Deenik J, 2019, SCHIZOPHR RES, V204, P360, DOI 10.1016/j.schres.2018.07.033
   Difrancesco S, 2019, DEPRESS ANXIETY, V36, P975, DOI 10.1002/da.22949
   Esliger DW, 2011, MED SCI SPORT EXER, V43, P1085, DOI 10.1249/MSS.0b013e31820513be
   Feliciano EMC, 2018, PEDIATRICS, V142, DOI 10.1542/peds.2017-4085
   Fiorillo A, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00434
   Firth J, 2018, WORLD PSYCHIATRY, V17, P365, DOI 10.1002/wps.20571
   Fraguas D, 2011, EUR NEUROPSYCHOPHARM, V21, P621, DOI 10.1016/j.euroneuro.2010.07.002
   Gluth A, 2018, LIFESTYLE INTERVENTI, P247
   Goracci A, 2016, J AFFECT DISORDERS, V196, P20, DOI 10.1016/j.jad.2016.02.034
   Grandner MA, 2012, J SLEEP RES, V21, P427, DOI 10.1111/j.1365-2869.2011.00990.x
   Gurusamy J, 2018, ASIAN J PSYCHIATR, V36, P73, DOI 10.1016/j.ajp.2018.06.018
   Harvey AG, 2006, DEV PSYCHOPATHOL, V18, P1147, DOI 10.1017/S095457940606055X
   Hay P, 2003, PSYCHIAT SERV, V54, P1028, DOI 10.1176/appi.ps.54.7.1028
   Hay PJ, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001541
   Hayes JF, 2015, ACTA PSYCHIAT SCAND, V131, P417, DOI 10.1111/acps.12408
   Hickie I, 2013, MED J AUSTRALIA, V198, P461, DOI 10.5694/mja13.10431
   Hickie IB, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-303
   Hickie IB, 2013, EARLY INTERV PSYCHIA, V7, P31, DOI 10.1111/j.1751-7893.2012.00366.x
   Hildebrand M, 2014, MED SCI SPORT EXER, V46, P1816, DOI 10.1249/MSS.0000000000000289
   Hill NR, 2013, DIABETES CARE, V36, P2324, DOI 10.2337/dc12-0607
   Hilsenroth MJ, 2000, AM J PSYCHIAT, V157, P1858, DOI 10.1176/appi.ajp.157.11.1858
   Humeniuk R, 2008, ADDICTION, V103, P1039, DOI 10.1111/j.1360-0443.2007.02114.x
   Jackson JG, 2015, BIPOLAR DISORD, V17, P575, DOI 10.1111/bdi.12319
   Jerrell JM, 2008, HUM PSYCHOPHARM CLIN, V23, P283, DOI 10.1002/hup.932
   Kessler RC, 2002, PSYCHOL MED, V32, P959, DOI 10.1017/S0033291702006074
   Lambert JD, 2018, J MED INTERNET RES, V20, DOI 10.2196/10112
   Larsen D L, 1979, Eval Program Plann, V2, P197, DOI 10.1016/0149-7189(79)90094-6
   Laursen TM, 2016, J AFFECT DISORDERS, V193, P203, DOI 10.1016/j.jad.2015.12.067
   Liu NH, 2017, WORLD PSYCHIATRY, V16, P30, DOI 10.1002/wps.20384
   Maayan L, 2011, J CHILD ADOL PSYCHOP, V21, P517, DOI 10.1089/cap.2011.0015
   Mallet J, 2019, EUR ARCH PSY CLIN N, V269, P449, DOI 10.1007/s00406-018-0873-7
   Martínez-Ortega JM, 2013, EUR CHILD ADOLES PSY, V22, P457, DOI 10.1007/s00787-013-0399-5
   McGorry PD, 2006, AUST NZ J PSYCHIAT, V40, P616, DOI 10.1080/j.1440-1614.2006.01860.x
   Meneses-Gaya Carolina de, 2009, Psychol. Neurosci., V2, P83
   Minassian A, 2010, J AFFECT DISORDERS, V120, P200, DOI 10.1016/j.jad.2009.04.018
   Mitchison D, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-943
   Morin CM, 2011, SLEEP, V34, P601, DOI 10.1093/sleep/34.5.601
   Murphy JA, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00091
   Nasstasia Y, 2018, CONT CLIN TRIAL COMM, V9, P13, DOI 10.1016/j.conctc.2017.11.007
   Newcombe DAL, 2005, DRUG ALCOHOL REV, V24, P217, DOI 10.1080/09595230500170266
   Norman SB, 2006, DEPRESS ANXIETY, V23, P245, DOI 10.1002/da.20182
   OVERALL JE, 1962, PSYCHOL REP, V10, P799
   Panagiotopoulos C, 2009, CAN J PSYCHIAT, V54, P743, DOI 10.1177/070674370905401104
   Parker AG., 2018, EXERCISE BASED INTER, P149
   Parker AG, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2019-034002
   Parker AG, 2016, J AFFECT DISORDERS, V196, P200, DOI 10.1016/j.jad.2016.02.043
   Pillay J, 2017, First- and second-generation antipsychotics in children and young adults: Systematic review update
   Prochaska JJ, 2017, ANNU REV PUBL HEALTH, V38, P165, DOI 10.1146/annurev-publhealth-031816-044618
   Quante M, 2019, J ADOLESCENT HEALTH, V65, P224, DOI 10.1016/j.jadohealth.2019.02.008
   Raniti MB, 2018, SLEEP, V41, DOI 10.1093/sleep/zsy066
   Richardson S, 2019, ADDICT BEHAV, V90, P14, DOI 10.1016/j.addbeh.2018.10.011
   Ringen PA, 2018, NORD J PSYCHIAT, V72, P296, DOI 10.1080/08039488.2018.1449012
   Roberts LW, 2017, ACAD PSYCHIATR, V41, P441, DOI 10.1007/s40596-017-0738-9
   Robillard R, 2015, J PSYCHIATR NEUROSCI, V40, P28, DOI 10.1503/jpn.130247
   Robins RW, 2001, PERS SOC PSYCHOL B, V27, P151, DOI 10.1177/0146167201272002
   Rohleder C, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2019-035379
   Rönngren Y, 2018, INT J MENT HEALTH NU, V27, P1022, DOI 10.1111/inm.12410
   Rosenbaum S, 2020, BMC PSYCHIATRY, V20, DOI 10.1186/s12888-020-2473-0
   Rosenbaum Simon, 2015, Internet Interventions, V2, P214, DOI 10.1016/j.invent.2015.04.001
   Rosenbaum S, 2016, LANCET PSYCHIAT, V3, pE1, DOI 10.1016/S2215-0366(15)00496-4
   Rosenberg M., 1965, MEASURES PACKAGE, V61, P18
   Rush AJ, 2003, BIOL PSYCHIAT, V54, P573, DOI 10.1016/S0006-3223(02)01866-8
   Safer DJ, 2004, J CLIN PSYCHOPHARM, V24, P429, DOI 10.1097/01.jcp.0000130558.86125.5b
   Schaefer CA, 2014, MED SCI SPORT EXER, V46, P826, DOI 10.1249/MSS.0000000000000150
   Scheewe TW, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00087
   Schuch F, 2017, J AFFECT DISORDERS, V210, P139, DOI 10.1016/j.jad.2016.10.050
   Scott EM, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2014-007066
   Scott J, 2013, BRIT J PSYCHIAT, V202, P243, DOI 10.1192/bjp.bp.112.110858
   Seida JC, 2012, PEDIATRICS, V129, pE771, DOI 10.1542/peds.2011-2158
   Shahid A., 2011, MUNICH CHRONOTYPE QU, P245
   Smout MF, 2019, AUST PSYCHOL, V54, P102, DOI 10.1111/ap.12376
   Smyth C, 1999, J Gerontol Nurs, V25, P10
   Soreca I, 2016, ACTA PSYCHIAT SCAND, V133, P453, DOI 10.1111/acps.12578
   Stigler Kimberly A, 2004, Paediatr Drugs, V6, P33, DOI 10.2165/00148581-200406010-00003
   Taylor CI, 2020, INT J SPORT EXERC PS, V18, P336, DOI 10.1080/1612197X.2018.1519838
   te Lindert BHW, 2013, SLEEP, V36, P781, DOI 10.5665/sleep.2648
   Teasdale SB, 2019, BRIT J PSYCHIAT, V214, P251, DOI 10.1192/bjp.2019.20
   van Hees VT, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0142533
   van Hees VT, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061691
   van Spijker BAJ, 2014, SUICIDE LIFE-THREAT, V44, P408, DOI 10.1111/sltb.12084
   Vancampfort D, 2017, WORLD PSYCHIATRY, V16, P308, DOI 10.1002/wps.20458
   Vancampfort D, 2017, J AFFECT DISORDERS, V224, P87, DOI 10.1016/j.jad.2016.07.042
   Vancampfort D, 2016, PSYCHIAT RES, V242, P7, DOI 10.1016/j.psychres.2016.05.023
   Vancampfort D, 2016, J AFFECT DISORDERS, V201, P145, DOI 10.1016/j.jad.2016.05.020
   Weinberger AH, 2018, J CLIN PSYCHIAT, V79, DOI 10.4088/JCP.17m11945
   World Health Organization, 2018, of chronic condi-tions
   Ngai YF, 2014, J CLIN PSYCHOPHARM, V34, P359, DOI 10.1097/JCP.0000000000000118
   YOUNG RC, 1978, BRIT J PSYCHIAT, V133, P429, DOI 10.1192/bjp.133.5.429
   Yung AR, 2005, AUST NZ J PSYCHIAT, V39, P964, DOI 10.1111/j.1440-1614.2005.01714.x
   Zuddas A, 2011, EUR NEUROPSYCHOPHARM, V21, P600, DOI 10.1016/j.euroneuro.2011.04.001
NR 118
TC 2
Z9 2
U1 4
U2 14
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2021
VL 11
IS 6
AR e044977
DI 10.1136/bmjopen-2020-044977
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA UJ4EO
UT WOS:000691240700014
PM 34187819
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Morelli, NR
   Maes, M
   Bonifacio, KL
   Vargas, HO
   Nunes, SOV
   Barbosa, DS
AF Morelli, Nayara Rampazzo
   Maes, Michael
   Bonifacio, Kamila Landucci
   Vargas, Heber Odebrecht
   Nunes, Sandra Odebrecht Vargas
   Barbosa, Decio Sabbatini
TI Increased nitro-oxidative toxicity in association with metabolic
   syndrome, atherogenicity and insulin resistance in patients with
   affective disorders
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Major depression; Bipolar disorder; Metabolic syndrome; oxidative and
   nitrosative stress; antioxidants biomarkers
ID MAJOR DEPRESSIVE DISORDER; LOW-DENSITY-LIPOPROTEIN; PROTEIN PRODUCTS;
   NITROSATIVE STRESS; MALONDIALDEHYDE; PLASMA; ATHEROSCLEROSIS;
   PEROXYNITRITE; DETERMINANT; BIOMARKERS
AB Background: There is a strong comorbidity between mood disorders and metabolic syndrome (MetS). Increased levels of reactive oxygen and nitrogen species (RONS) and nitro-oxidative stress toxicity (NOSTOX) partially underpin this comorbidity. Aims: To examine the associations of RONS/NOSTOX biomarkers with MetS after adjusting for the significant effects of mood disorders (major depression, and bipolar type 1 and 2), generalized anxiety disorder (GAD), tobacco use disorder (TUD), and male sex. Methods: The study included subjects with (n=65) and without (n=107) MetS and measured levels of superoxide dismutase 1 (SOD1), lipid hydroperoxides (LOOH), nitric oxide metabolites (NOx), malondialdehyde (MDA), and advanced oxidation protein products (AOPP) and computed z unit-weighted composite scores which reflect RONS/NOSTOX. The study included 105 patients with mood disorders, 46 with GAD, and 95 with TUD. Results: MetS was associated with increased levels of MDA and AOPP, independently from mood disorders, TUD, sex and GAD. Atherogenicity and insulin resistance (IR) were significantly associated with a NOSTOX composite score. Mood disorders, TUD, GAD, male sex and MetS independently contribute to increased RONS/NOSTOX. The RONS/NOSTOX profile of MetS was different from that of GAD, which showed increased SOD1 and NOx levels. TUD was accompanied by increased SOD1, LOOH and MDA, and male sex by increased LOOH and AOPP. Conclusions: MetS is characterized by increased lipid peroxidation with aldehyde formation and chlorinative stress, and atherogenicity and IR are strongly mediated by RONS/NOSTOX. Partially shared RONS/NOSTOX pathways underpin the comorbidity of MetS with mood disorders, GAD, and TUD.
C1 [Morelli, Nayara Rampazzo; Maes, Michael; Bonifacio, Kamila Landucci; Vargas, Heber Odebrecht; Nunes, Sandra Odebrecht Vargas; Barbosa, Decio Sabbatini] Univ Estadual Londrina, Hlth Sci Ctr, Hlth Sci Grad Program, Londrina, Parana, Brazil.
   [Maes, Michael] Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok, Thailand.
   [Maes, Michael] Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria.
   [Maes, Michael] Technol Ctr Emergency Med, Plovdiv, Bulgaria.
   [Maes, Michael] Deakin Univ, IMPACT Strateg Res Ctr, Geelong, Vic, Australia.
C3 Universidade Estadual de Londrina; Chulalongkorn University; Medical
   University Plovdiv; Deakin University
RP Maes, M (corresponding author), Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok, Thailand.
EM nayara.rampazzo@gmail.com; dr.michaelmaes@hotmail.com;
   kamilalondrina@hotmail.com; hebervargas@sercomtel.com.br;
   sandranunes@sercomtel.com.br; sabbatini2011@hotmail.com
RI Nunes, Sandra/B-4035-2019; Maes, Michael/B-8546-2011
OI Maes, Michael/0000-0002-2012-871X; Rampazzo Morelli,
   Nayara/0000-0001-7183-4668
FU Health Sciences Postgraduate Program at Londrina State University,
   Parana, Brazil (UEL); Ministry for Science and Technology of Brazil
   (CNPq); CNPq [470344/2013-0, 465928/2014-5]; CNPq-PVE fellowship; Health
   Sciences Graduate Program fellowship, State University of Londrina
FX This study was supported by Health Sciences Postgraduate Program at
   Londrina State University, Parana, Brazil (UEL) , and Ministry for
   Science and Technology of Brazil (CNPq) . CNPq number 470344/2013-0 and
   CNPq number 465928/2014-5. MM is supported by a CNPq-PVE fellowship and
   the Health Sciences Graduate Program fellowship, State University of
   Londrina.
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   American Psychiatric Association, 2000, spectrum disorders using the current DSM-IV-TR diagnostic, V4th, DOI 10.1176/dsm10.1176/appi.books.9780890420249.dsm-iv-tr
   Awadallah S, 2019, DIABETES METAB SYND, V13, P2541, DOI 10.1016/j.dsx.2019.07.010
   Ayala A, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/360438
   Bastos AS, 2012, ANAL BIOCHEM, V423, P141, DOI 10.1016/j.ab.2012.01.016
   Bonifácio KL, 2021, J AFFECT DISORDERS, V278, P226, DOI 10.1016/j.jad.2020.09.040
   Bonifácio KL, 2017, J AFFECT DISORDERS, V222, P185, DOI 10.1016/j.jad.2017.07.010
   Bortolasci CC, 2015, J AFFECT DISORDERS, V179, P148, DOI 10.1016/j.jad.2015.03.041
   Del-Ben Cristina Marta, 2001, Revista Brasileira de Psiquiatria, V23, P156, DOI 10.1590/S1516-44462001000300008
   Fazakerley DJ, 2018, J BIOL CHEM, V293, P7315, DOI 10.1074/jbc.RA117.001254
   FLECHA BG, 1991, FREE RADICAL BIO MED, V10, P93
   Fukai T, 2011, ANTIOXID REDOX SIGN, V15, P1583, DOI 10.1089/ars.2011.3999
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   HAMILTON M, 1959, BRIT J MED PSYCHOL, V32, P50, DOI 10.1111/j.2044-8341.1959.tb00467.x
   Hanasand M, 2012, CLIN CHIM ACTA, V413, P901, DOI 10.1016/j.cca.2012.01.038
   Ito T, 2018, HEART VESSELS, V33, P351, DOI 10.1007/s00380-017-1074-4
   Kayali R, 2007, MECH AGEING DEV, V128, P365, DOI 10.1016/j.mad.2007.03.003
   Kessler RC, 2003, JAMA-J AM MED ASSOC, V289, P3095, DOI 10.1001/jama.289.23.3095
   Ma BT, 2020, MOL MED REP, V22, P2599, DOI 10.3892/mmr.2020.11383
   MAES M, 1994, ACTA PSYCHIAT SCAND, V90, P252, DOI 10.1111/j.1600-0447.1994.tb01589.x
   Maes M, 2021, METAB BRAIN DIS, V36, P509, DOI 10.1007/s11011-020-00656-6
   Maes M, 2019, MOL NEUROBIOL, V56, P141, DOI 10.1007/s12035-018-1051-7
   Maes M, 2018, MOL NEUROBIOL, V55, P8885, DOI 10.1007/s12035-018-1016-x
   Maes M, 2019, MOL NEUROBIOL, V56, P6626, DOI 10.1007/s12035-019-1552-z
   Maes M, 2018, NEUROTOX RES, V34, P489, DOI 10.1007/s12640-018-9906-2
   Maes M, 2011, PROG NEURO-PSYCHOPH, V35, P676, DOI 10.1016/j.pnpbp.2010.05.004
   Marchio P, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8563845
   MARKLUND S, 1974, EUR J BIOCHEM, V47, P469
   Marsche G, 2009, CIRC RES, V104, P750, DOI 10.1161/CIRCRESAHA.108.193169
   Merikangas KR, 2007, ARCH GEN PSYCHIAT, V64, P543, DOI 10.1001/archpsyc.64.5.543
   Mo ZC, 2014, CIRC J, V78, P2760, DOI 10.1253/circj.CJ-14-0193
   Moraes JB, 2017, CNS NEUROL DISORD-DR, V16, P514, DOI 10.2174/1871527316666170407151514
   Moreira FP, 2019, BRAZ J PSYCHIAT, V41, P38, DOI 10.1590/1516-4446-2017-2328
   Moreno R.A., 1998, Revista de Psiquiatria Clinica, V25, P262
   Moreto F, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/505368
   Morita M, 2016, REDOX BIOL, V8, P127, DOI 10.1016/j.redox.2016.01.005
   Moylan S, 2014, NEUROSCI BIOBEHAV R, V45, P46, DOI 10.1016/j.neubiorev.2014.05.007
   Muthukumaran S, 2008, TOXICOLOGY, V243, P207, DOI 10.1016/j.tox.2007.10.006
   Navarro-Gonzálvez JA, 1998, CLIN CHEM, V44, P679
   Ndrepepa G, 2019, CLIN CHIM ACTA, V493, P36, DOI 10.1016/j.cca.2019.02.022
   Orekhov AN, 2014, INT J MOL SCI, V15, P12807, DOI 10.3390/ijms150712807
   Panis C, 2012, BREAST CANCER RES TR, V133, P89, DOI 10.1007/s10549-011-1693-x
   de Melo LGP, 2017, PROG NEURO-PSYCHOPH, V78, P34, DOI 10.1016/j.pnpbp.2017.04.027
   Pillon NJ, 2012, ENDOCRINOLOGY, V153, P2099, DOI 10.1210/en.2011-1957
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Stoyanov Drozdstoy S, 2010, Folia Med (Plovdiv), V52, P18
   Szabo C, 2007, NAT REV DRUG DISCOV, V6, P662, DOI 10.1038/nrd2222
   Tanaga K, 2002, ARTERIOSCL THROM VAS, V22, P662, DOI 10.1161/01.ATV.0000012351.63938.84
   Vargas HO, 2014, LIFE SCI, V102, P65, DOI 10.1016/j.lfs.2014.02.033
   Nunes SOV, 2015, J AFFECT DISORDERS, V172, P55, DOI 10.1016/j.jad.2014.09.038
   Nunes SOV, 2013, NEUROSCI BIOBEHAV R, V37, P1336, DOI 10.1016/j.neubiorev.2013.04.014
   Venturini D, 2015, NUTR RES, V35, P759, DOI 10.1016/j.nutres.2015.06.013
   Vona R, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8267234
   WitkoSarsat V, 1996, KIDNEY INT, V49, P1304, DOI 10.1038/ki.1996.186
   Yaribeygi H, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/8609213
   Zafar U, 2018, HORM-INT J ENDOCRINO, V17, P299, DOI 10.1007/s42000-018-0051-3
   Zhou QG, 2010, CELL PHYSIOL BIOCHEM, V26, P775, DOI 10.1159/000322345
NR 57
TC 20
Z9 20
U1 0
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD NOV 1
PY 2021
VL 294
BP 410
EP 419
DI 10.1016/j.jad.2021.07.057
EA JUL 2021
PG 10
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA UK0PQ
UT WOS:000691677800010
PM 34320448
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Bayerle, P
   Haufe, S
   Kück, M
   Protte, G
   Kerling, A
   Ewers, S
   Boeck, HT
   Sundermeier, T
   Ensslen, R
   Kahl, KG
   Haverich, A
   Tegtbur, U
   Nachbar, L
AF Bayerle, Pauline
   Haufe, Sven
   Kueck, Momme
   Protte, Gudrun
   Kerling, Arno
   Ewers, Simone
   Boeck, Hedwig Theda
   Sundermeier, Thorben
   Ensslen, Ralf
   Kahl, Kai G.
   Haverich, Axel
   Tegtbur, Uwe
   Nachbar, Lars
TI The Impact of Body Weight Changes versus Exercise Capacity Changes on
   Health-Related Factors following a Lifestyle Intervention in Employees
   with Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE physical activity; telemonitoring; nutrition; metabolic syndrome;
   company employees; health-related quality of life
ID CARDIOVASCULAR-DISEASE RISK; PRACTICE GUIDELINES; PHYSICAL-ACTIVITY;
   AMERICAN-COLLEGE; OBESITY; ASSOCIATION; MANAGEMENT; POPULATION;
   DEPRESSION; PREVALENCE
AB Background: Lifestyle changes are a cornerstone in the treatment of metabolic syndrome (MetS). However, evidence as to which components of the MetS and associated aspects of quality of life are driven by weight loss or improvements in exercise capacity are scarce. Methods: Company employees (n = 302, 48.2 +/- 8.2 years, BMI 33.2 +/- 5.4 kg/m(2)) with diagnosed MetS were evaluated after a 6-month telemonitoring-supported intervention (counselling in nutrition and physical activity) or wait-list control (delayed start of the same intervention). Results: Exercise capacity, body mass index (BMI), and MetS severity were improved after the intervention. Multivariable regression models revealed that changes in BMI were associated with changes in three components of MetS (waist circumference, triglycerides, blood glucose), whereas changes in exercise capacity only were associated to one MetS component change (systolic blood pressure) but also improvements in anxiety severity, aspects of quality of life, and work ability. Conclusions: Both physical activity promotion and diet should be part of a holistic treatment of patients with MetS. However, our data suggest that dietary-induced weight loss might be more successful when aiming at improving MetS risk factors, whereas focusing more on physical activity promotion might be preferred when targeting aspects in quality of life and mental health.
C1 [Bayerle, Pauline; Haufe, Sven; Kueck, Momme; Protte, Gudrun; Kerling, Arno; Ewers, Simone; Boeck, Hedwig Theda; Sundermeier, Thorben; Tegtbur, Uwe] Hannover Med Sch, Inst Sports Med, D-30625 Hannover, Germany.
   [Ensslen, Ralf; Nachbar, Lars] Volkswagen AG, D-38440 Wolfsburg, Germany.
   [Kahl, Kai G.] Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, D-30625 Hannover, Germany.
   [Haverich, Axel] Hannover Med Sch, Dept Cardiac Thorac Transplantat & Vasc Surg, D-30625 Hannover, Germany.
C3 Hannover Medical School; Volkswagen; Volkswagen Germany; Hannover
   Medical School; Hannover Medical School
RP Haufe, S (corresponding author), Hannover Med Sch, Inst Sports Med, D-30625 Hannover, Germany.
EM haufe.sven@mh-hannover.de
RI Haverich, Axel/AAC-7552-2022; Haufe, Sven/G-1944-2011
FU Audi BKK health insurance; German Research Foundation through the
   Cluster of Excellence "REBIRTH"
FX This study was supported and funded by grants from Audi BKK health
   insurance and the German Research Foundation through the Cluster of
   Excellence "REBIRTH". The funder of this study had no role in the study
   design, data collection, data analysis, data interpretation, writing of
   the report, or decision to submit for publication. All coauthors had
   access to the raw data if needed. The corresponding author had full
   access to all study data and had final responsibility for the decision
   to submit for publication.
CR [Anonymous], WHO guidelines on physical activity and sedentary behaviour
   Bayerle P, 2022, BMC SPORTS SCI MED R, V14, DOI 10.1186/s13102-022-00409-1
   Biccirè FG, 2022, NUTRIENTS, V14, DOI 10.3390/nu14061260
   Bullinger M, 1996, Rehabilitation (Stuttg), V35, pXVII
   Burton WN, 2008, J OCCUP ENVIRON MED, V50, P1139, DOI 10.1097/JOM.0b013e318188b8eb
   Carek PJ, 2011, INT J PSYCHIAT MED, V41, P15, DOI 10.2190/PM.41.1.c
   Chekroud SR, 2018, LANCET PSYCHIAT, V5, P739, DOI 10.1016/S2215-0366(18)30227-X
   Dekker JM, 2005, CIRCULATION, V112, P666, DOI 10.1161/CIRCULATIONAHA.104.516948
   dge, DTSCH GESELLSCHAFT F
   Finicelli M, 2022, NUTRIENTS, V14, DOI 10.3390/nu14142956
   Flegal KM, 2012, JAMA-J AM MED ASSOC, V307, P491, DOI 10.1001/jama.2012.39
   Frey I, 1999, SOZ PRAVENTIV MED, V44, P55, DOI 10.1007/BF01667127
   Gaesser GA, 2021, ISCIENCE, V24, DOI 10.1016/j.isci.2021.102995
   Garber CE, 2019, CURR SPORT MED REP, V18, P287, DOI 10.1249/JSR.0000000000000619
   Garvey WT, 2016, ENDOCR PRACT, V22, P1, DOI 10.4158/EP161365.GL
   Cabrera AG, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124560
   Grundy SM, 2016, TRENDS CARDIOVAS MED, V26, P364, DOI 10.1016/j.tcm.2015.10.004
   Grundy SM, 2005, CIRCULATION, V112, pE285, DOI 10.1161/CIRCULATIONAHA.105.169405
   Guthold R, 2018, LANCET GLOB HEALTH, V6, pE1077, DOI [10.1016/S2214-109X(18)30357-7, 10.1016/s2214-109x(18)30357-7]
   Haufe S, 2019, LANCET PUBLIC HEALTH, V4, pE343, DOI 10.1016/S2468-2667(19)30075-1
   Jehan Shazia, 2020, Adv Obes Weight Manag Control, V10, P146
   Jensen MD, 2014, J AM COLL CARDIOL, V63, P2985, DOI 10.1016/j.jacc.2013.11.004
   Kaspy MS, 2022, PROTEOMICS, V22, DOI 10.1002/pmic.202100388
   Kolotkin RL, 2017, CLIN OBES, V7, P273, DOI 10.1111/cob.12203
   Lavie CJ, 2014, CURR SPORT MED REP, V13, P240, DOI 10.1249/JSR.0000000000000067
   Lavie CJ, 2009, J AM COLL CARDIOL, V53, P1925, DOI 10.1016/j.jacc.2008.12.068
   Magkos F, 2009, ANNU REV NUTR, V29, P223, DOI 10.1146/annurev-nutr-080508-141200
   Marcos-Delgado A, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17103728
   Martínez-González MA, 2015, PROG CARDIOVASC DIS, V58, P50, DOI 10.1016/j.pcad.2015.04.003
   National Heart Lung and Blood Institute, METABOLIC SYNDROME C
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Ostman C, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-017-0590-y
   Posadzki P, 2020, BMC PUBLIC HEALTH, V20, DOI 10.1186/s12889-020-09855-3
   Puciato D, 2017, CLIN INTERV AGING, V12, P1627, DOI 10.2147/CIA.S144045
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Schultz AB, 2010, VALUE HEALTH, V13, P258, DOI 10.1111/j.1524-4733.2009.00651.x
   Snaith RP, 2002, J PSYCHOSOM RES, V52, P401
   van den Berg TIJ, 2009, OCCUP ENVIRON MED, V66, P211, DOI 10.1136/oem.2008.039883
   van Namen M, 2019, METABOLISM, V101, DOI 10.1016/j.metabol.2019.153988
   Varkevisser RDM, 2019, OBES REV, V20, P171, DOI 10.1111/obr.12772
   Wolfe BM, 2016, CIRC RES, V118, P1844, DOI 10.1161/CIRCRESAHA.116.307591
   World Health Organization (WHO), Obesity and overweight
NR 42
TC 1
Z9 1
U1 1
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2022
VL 14
IS 21
AR 4560
DI 10.3390/nu14214560
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 6B8KQ
UT WOS:000881576100001
PM 36364823
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cheng, C
   Wong, WM
   Lai, KC
   Wong, BCY
   Hu, WHC
   Hui, WM
   Lam, SK
AF Cheng, C
   Wong, WM
   Lai, KC
   Wong, BCY
   Hu, WHC
   Hui, WM
   Lam, SK
TI Psychosocial factors in patients with noncardiac chest pain
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE atypical chest pain; coping; noncardiac chest pain; psychosocial
   factors; stress
ID NORMAL CORONARY ARTERIOGRAMS; ISCHEMIC-HEART-DISEASE; SOCIAL SUPPORT;
   PSYCHIATRIC-ILLNESS; SYNDROME-X; COPING PROCESSES; LIFE STRESS;
   DEPRESSION; ANGINA; PERSONALITY
AB Objective: This study sought to explore some psychosocial factors that distinguished individuals with noncardiac chest pain (NCCP) from those without NCCP, and whether these psychosocial factors were associated with anxiety and depression that are co-morbid factors of NCCP. Methods: A matched case-control design was adopted to compare differences in psychosocial factors among a target group of patients with NCCP (N = 70), a pain control,group of patients with rheumatism (N = 70), and a community control group of healthy individuals (N = 70). Results: Compared with subjects from the two control groups, NCCP patients tended to monitor more, use more problem-focused coping, display a coping pattern with a poorer strategy-situation fit, and receive less emotional support in times of stress. Moreover, monitoring perceptual style and problem-focused coping were associated with hi-her levels of anxiety and depression. Coping pattern with a strategy-situation fit and emotional support were related to lower levels of anxiety and depression. Conclusions: The present new findings suggest that monitoring perceptual style and inflexible coping style are risk factors that enhance one's vulnerability to NCCP. Emotional support may be a resource factor that reduces one's susceptibility to NCCP.
C1 Hong Kong Univ Sci & Technol, Div Social Sci, Kowloon, Hong Kong, Peoples R China.
   Univ Hong Kong, Dept Med, Hong Kong, Hong Kong, Peoples R China.
C3 Hong Kong University of Science & Technology; University of Hong Kong
RP Hong Kong Univ Sci & Technol, Div Social Sci, Kowloon, Hong Kong, Peoples R China.
EM c.cheng@ust.hk
RI Wong, Benjamin/C-4436-2009; Cheng, Cecilia/A-2284-2010
OI Cheng, Cecilia/0000-0002-7250-2224
CR ALDWIN C, 1994, STRESS COPIN DEV
   ALLOWAY R, 1987, PSYCHOL MED, V17, P91, DOI 10.1017/S0033291700013015
   ANDERSON KO, 1989, DIGEST DIS SCI, V34, P83, DOI 10.1007/BF01536159
   [Anonymous], 1974, Support systems and community mental health: Lectures on concept development
   BARRERA M, 1981, AM J COMMUN PSYCHOL, V9, P435, DOI 10.1007/BF00918174
   BASS C, 1983, BMJ-BRIT MED J, V287, P1505, DOI 10.1136/bmj.287.6404.1505
   BEITMAN BD, 1988, PSYCHIAT CLIN N AM, V11, P387
   BILLINGS AG, 1984, J PERS SOC PSYCHOL, V46, P877, DOI 10.1037/0022-3514.46.4.877
   BOLGER N, 1991, J PERS, V59, P355, DOI 10.1111/j.1467-6494.1991.tb00253.x
   Brown G.W., 1989, LIFE EVENTS ILLNESS
   BURISCH M, 1984, AM PSYCHOL, V39, P214, DOI 10.1037/0003-066X.39.3.214
   Chan D.W., 1994, Psychological Assessment, V6, P108, DOI [DOI 10.1037/1040-3590.6.2.108, 10.1037/1040-3590.6.2.108]
   CHAUHAN A, 1994, J AM COLL CARDIOL, V24, P329, DOI 10.1016/0735-1097(94)90284-4
   Cheng C, 2001, J PERS SOC PSYCHOL, V80, P814, DOI 10.1037//3415.80.5.814
   Cheng C, 2001, J PERS, V69, P765, DOI 10.1111/1467-6494.695163
   Cheng C, 1998, J CLIN PSYCHOL, V54, P845, DOI 10.1002/(SICI)1097-4679(199810)54:6<845::AID-JCLP13>3.0.CO;2-L
   Cheng C, 1999, PSYCHOSOM MED, V61, P789, DOI 10.1097/00006842-199911000-00011
   Cheng C, 2000, HEALTH PSYCHOL, V19, P146, DOI 10.1037/0278-6133.19.2.146
   CLARK DM, 1986, BEHAV RES THER, V24, P461, DOI 10.1016/0005-7967(86)90011-2
   CLOUSE RE, 1983, NEW ENGL J MED, V309, P1337, DOI 10.1056/NEJM198312013092201
   COHEN J, 1968, PSYCHOL BULL, V70, P213, DOI 10.1037/h0026256
   COHEN S, 1985, PSYCHOL BULL, V98, P310, DOI 10.1037/0033-2909.98.2.310
   CORMIER LE, 1988, J NERV MENT DIS, V176, P351, DOI 10.1097/00005053-198806000-00004
   Fallon J T, 1990, Chin Med J (Engl), V103, P110
   FIELD JL, 1994, RULEOUT BEST PRACTIC
   FIORE J, 1983, AM J COMMUN PSYCHOL, V11, P423, DOI 10.1007/BF00894057
   FOLKMAN S, 1984, J PERS SOC PSYCHOL, V46, P839, DOI 10.1037/0022-3514.46.4.839
   FOLKMAN S, 1987, PSYCHOL AGING, V2, P171, DOI 10.1037/0882-7974.2.2.171
   FORSYTHE CJ, 1987, COGNITIVE THER RES, V11, P473, DOI 10.1007/BF01175357
   FRASURESMITH N, 1987, J PSYCHOSOM RES, V31, P545, DOI 10.1016/0022-3999(87)90033-X
   FRIEDLAND N, 1992, J PERS SOC PSYCHOL, V63, P923, DOI 10.1037/0022-3514.63.6.923
   GANSTER DC, 1988, BRIT J MED PSYCHOL, V61, P17, DOI 10.1111/j.2044-8341.1988.tb02763.x
   GROSSMAN P, 1983, PSYCHOPHYSIOLOGY, V20, P284, DOI 10.1111/j.1469-8986.1983.tb02156.x
   Hsi Y Y, 1990, J Formos Med Assoc, V89, P606
   KATON W, 1988, AM J MED, V84, P1, DOI 10.1016/0002-9343(88)90001-0
   Kim KI, 1997, INT J SOC PSYCHIATR, V43, P87, DOI 10.1177/002076409704300202
   LAGERQVIST B, 1992, BRIT HEART J, V68, P282
   Lau GKK, 1996, AM J GASTROENTEROL, V91, P2157
   Lau KC, 1996, J GASTROEN HEPATOL, V11, P775, DOI 10.1111/j.1440-1746.1996.tb00331.x
   LAVEY EB, 1979, J CHRON DIS, V32, P191, DOI 10.1016/0021-9681(79)90064-X
   Lazarus R. S., 1984, Stress, appraisal, and coping, DOI [10.1007/978-3-030-39903-0_215, DOI 10.1007/978-1-4419-1005-9_215]
   Lefcourt H.M., 1992, Personal coping: Theory, research, and application, P111
   LEPORE SJ, 1992, J PERS SOC PSYCHOL, V63, P857, DOI 10.1037/0022-3514.63.5.857
   LEVENSON JL, 1989, PSYCHOSOM MED, V51, P27, DOI 10.1097/00006842-198901000-00003
   刘仁刚, 2001, 中国心理卫生杂志, V15, P28
   MA LCJ, 1990, STUDY SOCIAL SUPPORT
   MARGRAF J, 1987, J NERV MENT DIS, V175, P558, DOI 10.1097/00005053-198709000-00008
   Marusic A, 1999, NORD J PSYCHIAT, V53, P191, DOI 10.1080/080394899427197
   MARX EM, 1991, J CLIN PSYCHOL, V47, P361, DOI 10.1002/1097-4679(199105)47:3<361::AID-JCLP2270470307>3.0.CO;2-L
   MATEOS JLA, 1989, PSYCHOTHER PSYCHOSOM, V52, P92
   MATTLIN JA, 1990, J HEALTH SOC BEHAV, V31, P103, DOI 10.2307/2137048
   MAYOU R, 1989, GEN HOSP PSYCHIAT, V11, P307, DOI 10.1016/0163-8343(89)90117-5
   MAYOU R, 1989, J PSYCHOSOM RES, V33, P393, DOI 10.1016/0022-3999(89)90001-9
   Miller S., 1992, PERSONAL COPING THEO, P77
   MILLER SM, 1995, CANCER, V76, P167, DOI 10.1002/1097-0142(19950715)76:2<167::AID-CNCR2820760203>3.0.CO;2-K
   Miller SM, 1996, HEALTH PSYCHOL, V15, P216, DOI 10.1037/0278-6133.15.3.216
   MILLER SM, 1991, LIFE CRISES EXPERIEN, P311
   MORA G, 1980, J HIST BEHAV SCI, V16, P58, DOI 10.1002/1520-6696(198001)16:1<58::AID-JHBS2300160108>3.0.CO;2-M
   MORA G, 1978, J HIST BEHAV SCI, V14, P344, DOI 10.1002/1520-6696(197810)14:4<344::AID-JHBS2300140406>3.0.CO;2-H
   OCKENE IS, 1980, NEW ENGL J MED, V303, P1249, DOI 10.1056/NEJM198011273032201
   PAGEL M, 1987, J PERS SOC PSYCHOL, V52, P1043, DOI 10.1037/0022-3514.52.5.1043
   PAPANICOLAOU MN, 1986, AM J CARDIOL, V58, P1181, DOI 10.1016/0002-9149(86)90378-4
   PEARCE S, 1983, J PSYCHOSOM RES, V27, P431, DOI 10.1016/0022-3999(83)90082-X
   Rapee RM, 1997, BEHAV RES THER, V35, P741, DOI 10.1016/S0005-7967(97)00022-3
   ROLL M, 1990, J INTERN MED, V228, P223, DOI 10.1111/j.1365-2796.1990.tb00222.x
   ROLL M, 1988, ACTA MED SCAND, V224, P237
   ROSEN SD, 1994, CIRCULATION, V90, P50, DOI 10.1161/01.CIR.90.1.50
   Roth DA, 2001, PSYCHIAT CLIN N AM, V24, P753, DOI 10.1016/S0193-953X(05)70261-6
   SARASON IG, 1990, J SOC CLIN PSYCHOL, V9, P133, DOI 10.1521/jscp.1990.9.1.133
   SCHUSTER MM, 1983, NEW ENGL J MED, V309, P1382, DOI 10.1056/NEJM198312013092208
   SERLIE AW, 1995, PSYCHOTHER PSYCHOSOM, V64, P62, DOI 10.1159/000288993
   Shafran R., 1996, Behavioural and Cognitive Psychotherapy, V24, P209, DOI [DOI 10.1017/S1352465800015071, 10.1017/s1352465800015071]
   SHAPIRO LM, 1988, BRIT MED J, V296, P170, DOI 10.1136/bmj.296.6616.170-a
   THOITS PA, 1982, J COMMUNITY PSYCHOL, V10, P341, DOI 10.1002/1520-6629(198210)10:4<341::AID-JCOP2290100406>3.0.CO;2-J
   THOITS PA, 1982, J HEALTH SOC BEHAV, V23, P145, DOI 10.2307/2136511
   Thompson LW, 1996, J CLIN PSYCHIAT, V57, P29
   Thompson SC, 1996, J PERS SOC PSYCHOL, V70, P1307, DOI 10.1037/0022-3514.70.6.1307
   TURIEL M, 1987, AM J CARDIOL, V60, P503, DOI 10.1016/0002-9149(87)90294-3
   TYRER P, 1980, PSYCHOL MED, V10, P171, DOI 10.1017/S0033291700039726
   Tyrer P., 1976, ROLE BODILY FEELINGS
   VITALIANO PP, 1990, J PERS SOC PSYCHOL, V59, P582, DOI 10.1037/0022-3514.59.3.582
   VONSCHEELE C, 1986, LANCET, V1, P258
   WIELGOSZ AT, 1986, PSYCHOSOM MED, V48, P118, DOI 10.1097/00006842-198601000-00010
   Yamori Y, 2001, HYPERTENS RES, V24, P453, DOI 10.1291/hypres.24.453
   ZHOU HH, 1989, NEW ENGL J MED, V320, P565, DOI 10.1056/NEJM198903023200905
   Zuckerman M., 1985, Manual for the Multiple Affect Adjective Checklist
NR 86
TC 32
Z9 35
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD MAY-JUN
PY 2003
VL 65
IS 3
BP 443
EP 449
DI 10.1097/01.PSY.0000041623.24456.99
PG 7
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 683QH
UT WOS:000183160300017
PM 12764218
DA 2025-06-11
ER

PT J
AU Vinberg, M
   Madsen, M
   Breum, L
   Kessing, LV
   Fink-Jensen, A
AF Vinberg, Maj
   Madsen, Maiken
   Breum, Leif
   Kessing, Lars V.
   Fink-Jensen, Anders
TI Metabolic syndrome in a cohort of affectively ill patients, a
   naturalistic study
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Metabolic syndrome; Mood disorder; Prevalence
ID CARDIOVASCULAR-DISEASE; BIPOLAR DISORDER; MENTAL-DISORDER; DEPRESSION;
   MORTALITY; RISK; PREVALENCE
AB Background: Patients with affective disorder have higher mortality not only because of their affective illness but also because of a higher risk of death from physical illness especially cardiovascular diseases. Aim: To investigate the prevalence in a naturalistic cohort of patient treated at a Mood Disorder Clinic. Methods: Patients were evaluated for the presence of metabolic syndrome (MeS) according to modified NCEP ATP III criteria. Results: Of the 143 patients eligible for participation, 100 patients participated in the study (32% male, mean age 43.6 +/- 14.2); the prevalence of MeS was 26%. Higher age and high body mass index (BMI) were significantly associated with MeS. No association between present medication and MeS was seen. Conclusion: More than a quarter of affectively ill patients had MeS, which emphasizes the importance of integrated somatic and psychiatric care in order to reduce this group of patients' risk profile concerning cardiovascular diseases and diabetes. Clinically, it seems reasonable to prioritize overweight and obese patients for further examination.
C1 [Vinberg, Maj; Kessing, Lars V.; Fink-Jensen, Anders] Univ Copenhagen Hosp, Rigshosp, Dept Psychiat, DK-2100 Copenhagen, Denmark.
   [Madsen, Maiken] Univ Copenhagen, Copenhagen, Denmark.
   [Breum, Leif] Koge Hosp, Dept Med, Koge Sygehus, Koge, Denmark.
C3 Rigshospitalet; University of Copenhagen; Copenhagen University
   Hospital; University of Copenhagen
RP Vinberg, M (corresponding author), Univ Copenhagen Hosp, Rigshosp, Dept Psychiat, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
EM maj.vinberg@regionh.dk
RI Vinberg/ABC-7493-2021; Kessing, Lars/JNS-2493-2023
OI Fink-Jensen, Anders/0000-0001-7143-1236; Kessing,
   Lars/0000-0001-9377-9436; Vinberg, Maj/0000-0002-5982-1335
FU Janssen-Cilag; Eli Lilly; Pfizer
FX MV has been a consultant for Servier and AstraZeneca and has received
   speakers fees from Janssen-Cilag and Eli Lilly, all unrelated to the
   present study.Leif Breum has received speakers fees from Janssen-Cilag,
   Eli Lilly and Pfizer, all unrelated to the present study.
CR Bhuvaneswar CG, 2009, CNS DRUGS, V23, P1003, DOI 10.2165/11530020-000000000-00000
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Fava M, 2000, J CLIN PSYCHIAT, V61, P37
   Gans ROB, 2006, MED CLIN N AM, V90, P573, DOI 10.1016/j.mcna.2006.05.002
   Garcia-Portilla MP, 2008, J AFFECT DISORDERS, V106, P197, DOI 10.1016/j.jad.2007.06.002
   Gothefors D, 2010, NORD J PSYCHIAT, V64, P294
   Grundy SM, 2006, CURR OPIN CARDIOL, V21, P1, DOI 10.1097/01.hco.0000200416.65370.a0
   Harris EC, 1998, BRIT J PSYCHIAT, V173, P11, DOI 10.1192/bjp.173.1.11
   Heiskanen TH, 2006, J CLIN PSYCHIAT, V67, P1422, DOI 10.4088/JCP.v67n0913
   Jeppesen J, 2007, J AM COLL CARDIOL, V49, P2112, DOI 10.1016/j.jacc.2007.01.088
   Kessing LV, 2010, BRIT J PSYCHIAT, V197, P266, DOI 10.1192/bjp.bp.109.076935
   Krane-Gartiser K, 2011, NORD J PSYCHIAT
   Laursen TM, 2009, ARCH GEN PSYCHIAT, V66, P713, DOI 10.1001/archgenpsychiatry.2009.61
   McIntyre Roger S, 2005, Ann Clin Psychiatry, V17, P83, DOI 10.1080/10401230590932380
   McIntyre RS, 2010, J AFFECT DISORDERS, V126, P366, DOI 10.1016/j.jad.2010.04.012
   Miettola J, 2008, SCAND J PRIM HEALTH, V26, P203, DOI 10.1080/02813430802117624
   Murray DP, 2009, CURR PSYCHIAT REP, V11, P475, DOI 10.1007/s11920-009-0072-3
   Teixeira PJR, 2007, REV BRAS PSIQUIATR, V29, P330, DOI 10.1590/S1516-44462007000400007
NR 18
TC 5
Z9 7
U1 0
U2 1
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0803-9488
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PD APR
PY 2012
VL 66
IS 2
BP 142
EP 145
DI 10.3109/08039488.2011.595821
PG 4
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 915US
UT WOS:000302053500010
PM 21770840
DA 2025-06-11
ER

PT J
AU Mehdi, S
   Wani, SUD
   Krishna, KL
   Kinattingal, N
   Roohi, TF
AF Mehdi, Seema
   Wani, Shahid Ud Din
   Krishna, K. L.
   Kinattingal, Nabeel
   Roohi, Tamsheel Fatima
TI A review on linking stress, depression, and insulin resistance via
   low-grade chronic inflammation
SO BIOCHEMISTRY AND BIOPHYSICS REPORTS
LA English
DT Review
DE Major depressive disorder; Low-grade chronic inflammation; Chronic
   stress; Insulin resistance; Metabolic syndrome; Neurodegeneration;
   Pharmacological intervention
ID QUALITY-OF-LIFE; PATIENT-REPORTED OUTCOMES; C-REACTIVE PROTEIN;
   METABOLIC SYNDROME; DOUBLE-BLIND; OXIDATIVE STRESS; HEART-RATE;
   CARDIOVASCULAR-DISEASE; MEDITERRANEAN ISLANDS; IMMUNOLOGICAL ASPECTS
AB Stress is a disturbance in homeostasis caused by psychological, physiological, or environmental factors. Prolonged reactions to chronic stress can be detrimental, resulting in various metabolic abnormalities, referred to as metabolic syndrome (MS). There is a reciprocal increased risk between MS and major depressive disorder. Recent studies established an association between inflammation and insulin signaling in type 2 diabetes mellitus with depression. In the present review, we discuss chronic low-grade inflammation, pathways of insulin resistance, and brain glucose metabolism in the context of neuroinflammation and depression. Specific attention is given to psychotropic drugs such as bupropion, mirtazapine, and nefazodone, anti-inflammatory drugs like Celecoxib (COX-2 inhibitor), Etanercept, adalimumab, IL-4Ra antagonist, Anti-IL- 17A antibody (Ixekizumab) and lifestyle modifications including exercise, dietary changes, and sleep hygiene. These therapeutic solutions offer potential in treating depression by targeting metabolic conditions like insulin resistance and inflammatory pathways. The article further explains the significance of a nutrition and antioxidants-rich diet, emphasizing the role of omega-3 fatty acids, vitamin D, zinc, and polyphenols, to improve immunity and activate anti-inflammatory signaling pathways.
C1 [Mehdi, Seema; Krishna, K. L.; Kinattingal, Nabeel; Roohi, Tamsheel Fatima] JSS Acad Higher Educ & Res, JSS Coll Pharm, Dept Pharmacol, Mysore 570015, Karnataka, India.
   [Wani, Shahid Ud Din] Univ Kashmir, Sch Appl Sci & Technol, Dept Pharmaceut Sci, Srinagar 190006, India.
C3 JSS Academy of Higher Education & Research; JSS College of Pharmacy,
   Mysuru; University of Kashmir
RP Mehdi, S; Krishna, KL (corresponding author), JSS Acad Higher Educ & Res, JSS Coll Pharm, Dept Pharmacol, Mysore 570015, Karnataka, India.
EM seemamehdi@jssuni.edu.in; klkrishna@jssuni.edu.in
RI Krishna, Kamsagara/J-9408-2016; Mehdi, Seema/AAY-9912-2020
OI /0000-0002-8785-269X; Kinattingal, Nabeel/0000-0002-2248-3408
CR Aboobacker S., 2023, StatPearls
   Akbaraly TN, 2011, DIABETES CARE, V34, P904, DOI 10.2337/dc10-1644
   Almeida OP, 2004, PSYCHONEUROENDOCRINO, V29, P1071, DOI 10.1016/j.psyneuen.2003.11.002
   Altug H, 2020, ENVIRON INT, V136, DOI 10.1016/j.envint.2019.105448
   Amer Diabet Assoc, 2004, DIABETES CARE, V27, P596, DOI 10.2337/diacare.27.2.596
   Anglin RES, 2013, BRIT J PSYCHIAT, V202, P100, DOI 10.1192/bjp.bp.111.106666
   Atlantis E, 2008, INT J OBESITY, V32, P715, DOI 10.1038/sj.ijo.0803762
   Badescu S V, 2016, J Med Life, V9, P120
   Bains N., 2021, StatPearls
   Balhara Yatan Pal Singh, 2011, Indian J Endocrinol Metab, V15, P274, DOI 10.4103/2230-8210.85579
   Bao AM, 2008, BRAIN RES REV, V57, P531, DOI 10.1016/j.brainresrev.2007.04.005
   Basavaraju SM, 2023, NEUROSCI LETT, V814, DOI 10.1016/j.neulet.2023.137441
   Beesdo K, 2010, SOC PSYCH PSYCH EPID, V45, P89, DOI 10.1007/s00127-009-0045-1
   Benthem L, 2000, AM J PHYSIOL-ENDOC M, V279, pE1286, DOI 10.1152/ajpendo.2000.279.6.E1286
   Bergmans RS, 2017, PREV MED, V99, P313, DOI 10.1016/j.ypmed.2017.03.016
   Beurel E, 2020, NEURON, V107, P234, DOI 10.1016/j.neuron.2020.06.002
   Biagini G, 2010, CURR OPIN NEUROL, V23, P170, DOI 10.1097/WCO.0b013e32833735cf
   Bonnet F, 2005, J HYPERTENS, V23, P611, DOI 10.1097/01.hjh.0000160219.71350.d2
   Bonnet F, 2005, ATHEROSCLEROSIS, V178, P339, DOI 10.1016/j.atherosclerosis.2004.08.035
   Bountziouka V, 2009, J AGING HEALTH, V21, P864, DOI 10.1177/0898264309340693
   Brigitta Bondy, 2002, Dialogues Clin Neurosci, V4, P7
   Carney RM, 2005, PSYCHOSOM MED, V67, pS29, DOI 10.1097/01.psy.0000162254.61556.d5
   Casey DE, 2004, J CLIN PSYCHIAT, V65, P27
   Catena-Dell'Osso M, 2011, CURR MED CHEM, V18, P245, DOI 10.2174/092986711794088353
   Chen XW, 2017, PSYCHIAT RES, V256, P207, DOI 10.1016/j.psychres.2017.06.041
   Cheng CW, 2017, CELL, V168, P775, DOI 10.1016/j.cell.2017.01.040
   Clapp M, 2017, CLINICS PRACT, V7, P131, DOI 10.4081/cp.2017.987
   Connolly KR, 2012, EXPERT OPIN EMERG DR, V17, P105, DOI 10.1517/14728214.2012.660146
   D'haenen H., 2002, Biological Psychiatry, V1
   Daré LO, 2019, BMC PUBLIC HEALTH, V19, DOI 10.1186/s12889-019-6623-6
   de Luca C, 2008, FEBS LETT, V582, P97, DOI 10.1016/j.febslet.2007.11.057
   Sena Eduardo Pondé de, 2003, Braz. J. Psychiatry, V25, P253
   DeBattista C, 2006, TRENDS ENDOCRIN MET, V17, P117, DOI 10.1016/j.tem.2006.02.006
   DEFRONZO RA, 1991, DIABETES CARE, V14, P173, DOI 10.2337/diacare.14.3.173
   Derenne JL, 2006, ACAD PSYCHIATR, V30, P257, DOI 10.1176/appi.ap.30.3.257
   Diniz BS, 2018, INT J GERIATR PSYCH, V33, pE294, DOI 10.1002/gps.4792
   Duarte JMN, 2015, AGING DIS, V6, P304, DOI 10.14336/AD.2014.1104
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Ellulu MS, 2017, ARCH MED SCI, V13, P851, DOI 10.5114/aoms.2016.58928
   Festa A, 2000, DIABETES CARE, V23, P624, DOI 10.2337/diacare.23.5.624
   Flores BH, 2006, NEUROPSYCHOPHARMACOL, V31, P628, DOI 10.1038/sj.npp.1300884
   Ford AH, 2015, AM J GERIAT PSYCHIAT, V23, P872, DOI 10.1016/j.jagp.2014.10.010
   Gadalla T, 2008, WOMEN HEALTH, V48, P467, DOI 10.1080/03630240802575104
   Gans ROB, 2006, MED CLIN N AM, V90, P573, DOI 10.1016/j.mcna.2006.05.002
   Gheshlagh RG, 2016, IRAN RED CRESCENT ME, V18, DOI 10.5812/ircmj.26523
   Gold PW, 2013, MOL PSYCHIATR, V18, P154, DOI 10.1038/mp.2012.167
   Griffiths CEM, 2017, PSYCHOTHER PSYCHOSOM, V86, P260, DOI 10.1159/000479163
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Gu XY, 2021, BIOMED PHARMACOTHER, V141, DOI 10.1016/j.biopha.2021.111869
   Hage MP, 2012, J THROID RES, V2012, DOI 10.1155/2012/590648
   Hale A, 2010, INT CLIN PSYCHOPHARM, V25, P305, DOI 10.1097/YIC.0b013e32833a86aa
   Hashmi AM, 2013, PAK J MED SCI, V29, P877, DOI 10.12669/pjms.293.3357
   Hasin DS, 2018, JAMA PSYCHIAT, V75, P336, DOI 10.1001/jamapsychiatry.2017.4602
   Hoek HW, 2005, AM J PSYCHIAT, V162, P748, DOI 10.1176/appi.ajp.162.4.748
   Holt RIG, 2014, CURR DIABETES REP, V14, DOI 10.1007/s11892-014-0491-3
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Joaquim HPG, 2012, J PSYCHIATR RES, V46, P1053, DOI 10.1016/j.jpsychires.2012.04.020
   Joffe Russell T, 2011, Dialogues Clin Neurosci, V13, P127
   Kamenov K, 2017, PSYCHOL MED, V47, P414, DOI 10.1017/S0033291716002774
   Kangethe A, 2021, BMC HEALTH SERV RES, V21, DOI 10.1186/s12913-021-06802-9
   Kasper S, 2010, J CLIN PSYCHIAT, V71, P109, DOI 10.4088/JCP.09m05347blu
   Keller MB, 2000, NEW ENGL J MED, V342, P1462, DOI 10.1056/NEJM200005183422001
   Khan MS, 2019, MOL NEUROBIOL, V56, P671, DOI 10.1007/s12035-018-1101-1
   Khoodoruth MAS, 2022, FRONT PSYCHIATRY, V13, DOI 10.3389/fpsyt.2022.886918
   Kinattingal N, 2023, J PERS MED, V13, DOI 10.3390/jpm13030524
   Kodali R, 2006, CARDIOVASC RES, V69, P706, DOI 10.1016/j.cardiores.2005.09.012
   Köhler O, 2016, AM J PSYCHIAT, V173, P807, DOI 10.1176/appi.ajp.2016.15040463
   Lange KW, 2022, FOOD SCI HUM WELL, V11, P476, DOI [10.1016/j.fshw.2021.12.005, 10.1016/j.fshw.2021.12.032]
   Langley RG, 2010, J AM ACAD DERMATOL, V63, P457, DOI 10.1016/j.jaad.2009.09.014
   Lee YJ, 2010, ARCH PHARM RES, V33, P1539, DOI 10.1007/s12272-010-1006-7
   Leonard BE, 2020, ACTA NEUROPSYCHIATR, V32, P1, DOI 10.1017/neu.2019.17
   Limbana T, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.9966
   Liu YZ, 2017, FRONT HUM NEUROSCI, V11, DOI 10.3389/fnhum.2017.00316
   Loftus EV, 2008, AM J GASTROENTEROL, V103, P3132, DOI 10.1111/j.1572-0241.2008.02175.x
   LOOSEN PT, 1986, PHARMACOPSYCHIATRY, V19, P401, DOI 10.1055/s-2007-1017278
   Maiese K, 2007, CURR NEUROVASC RES, V4, P63, DOI 10.2174/156720207779940653
   Mamplekou E, 2010, J NUTR HEALTH AGING, V14, P449
   Mansur RB, 2015, NEUROSCI BIOBEHAV R, V52, P89, DOI 10.1016/j.neubiorev.2014.12.017
   Maydych V, 2019, FRONT NEUROSCI-SWITZ, V13, DOI 10.3389/fnins.2019.00384
   McIntyre Roger S, 2005, Ann Clin Psychiatry, V17, P83, DOI 10.1080/10401230590932380
   Menter A, 2010, J AM ACAD DERMATOL, V62, P812, DOI 10.1016/j.jaad.2009.07.022
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Mikulska J, 2021, BRAIN SCI, V11, DOI 10.3390/brainsci11101298
   Miller GE, 2008, BIOL PSYCHIAT, V64, P266, DOI 10.1016/j.biopsych.2008.03.017
   Minihane AM, 2015, BRIT J NUTR, V114, P999, DOI 10.1017/S0007114515002093
   Mocking RJT, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.29
   Moncrieff J, 2023, MOL PSYCHIATR, V28, P3243, DOI 10.1038/s41380-022-01661-0
   Müller N, 2017, DIALOGUES CLIN NEURO, V19, P55
   Musselman DL, 2003, BIOL PSYCHIAT, V54, P317, DOI 10.1016/S0006-3223(03)00569-9
   Na KS, 2014, PROG NEURO-PSYCHOPH, V48, P79, DOI 10.1016/j.pnpbp.2013.09.006
   Nestler EJ, 2002, NEURON, V34, P13, DOI 10.1016/S0896-6273(02)00653-0
   Okla M, 2017, ADV NUTR, V8, P473, DOI 10.3945/an.116.014332
   Ono K, 2011, J APPL PHYSIOL, V110, P789, DOI 10.1152/japplphysiol.00128.2010
   Osimo EF, 2020, BRAIN BEHAV IMMUN, V87, P901, DOI 10.1016/j.bbi.2020.02.010
   Oxenkrug G, 2013, MOL NEUROBIOL, V48, P294, DOI 10.1007/s12035-013-8497-4
   Paddick SM, 2017, ACTA NEUROPSYCHIATR, V29, P244, DOI 10.1017/neu.2016.65
   Pailla K, 2001, CLIN NUTR, V20, P313, DOI 10.1054/clnu.2001.0421
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pangalos MN, 2007, NAT REV DRUG DISCOV, V6, P521, DOI 10.1038/nrd2094
   Panzer C, 2002, DIABETES, V51, P803, DOI 10.2337/diabetes.51.3.803
   Pearson S, 2010, DIABETES CARE, V33, P1128, DOI 10.2337/dc09-1940
   Petersen KF, 2004, NEW ENGL J MED, V350, P664, DOI 10.1056/NEJMoa031314
   Pu JC, 2021, MOL PSYCHIATR, V26, P4265, DOI 10.1038/s41380-020-0645-4
   Puustinen PJ, 2011, PSYCHOSOM MED, V73, P158, DOI 10.1097/PSY.0b013e3182037315
   Raison CL, 2006, TRENDS IMMUNOL, V27, P24, DOI 10.1016/j.it.2005.11.006
   Rasgon NL, 2016, MOL PSYCHIATR, V21, P1648, DOI 10.1038/mp.2016.162
   Rasgon NL, 2005, NEUROBIOL AGING, V26, pS103
   Richelson E, 2013, INT J NEUROPSYCHOPH, V16, P1433, DOI 10.1017/S1461145712001605
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Salahudeen MS, 2020, THER ADV DRUG SAF, V11, DOI 10.1177/2042098620937899
   Salas-Salvado J., 2014, Ann Intern Med
   Salim S, 2017, J PHARMACOL EXP THER, V360, P201, DOI 10.1124/jpet.116.237503
   Samuels MH, 2014, CURR OPIN ENDOCRINOL, V21, P377, DOI 10.1097/MED.0000000000000089
   Sao R, 2018, ARCH MED SCI, V14, P1233, DOI 10.5114/aoms.2017.68821
   Sarris J, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/1471-244X-14-107
   Sas K, 2007, J NEUROL SCI, V257, P221, DOI 10.1016/j.jns.2007.01.033
   Schmidt PJ, 2004, ARCH GEN PSYCHIAT, V61, P997, DOI 10.1001/archpsyc.61.10.997
   Schreiner TG, 2021, J CLIN MED, V10, DOI 10.3390/jcm10122689
   Sheline YI, 1996, P NATL ACAD SCI USA, V93, P3908, DOI 10.1073/pnas.93.9.3908
   Simmons WK, 2016, AM J PSYCHIAT, V173, P418, DOI 10.1176/appi.ajp.2015.15020162
   Simpson EL, 2016, J AM ACAD DERMATOL, V75, P506, DOI 10.1016/j.jaad.2016.04.054
   Song Y, 2019, KOREAN J FAM MED, V40, P116, DOI 10.4082/kjfm.17.0075
   Steiner J, 2008, J PSYCHIATR RES, V42, P151, DOI 10.1016/j.jpsychires.2006.10.013
   Sun Y, 2017, BRAIN BEHAV IMMUN, V66, P156, DOI 10.1016/j.bbi.2017.06.014
   Swardfager W, 2013, NEUROSCI BIOBEHAV R, V37, P911, DOI 10.1016/j.neubiorev.2013.03.018
   Swarup S., 2022, Metabolic Syndrome
   Takahashi M, 2018, ACTA NEUROPSYCHIATR, V30, P350, DOI 10.1017/neu.2018.17
   Takeuchi T, 2009, DIABETES METAB, V35, P32, DOI 10.1016/j.diabet.2008.06.006
   Taylor WD, 2013, MOL PSYCHIATR, V18, P963, DOI 10.1038/mp.2013.20
   Teixeira Paulo José Ribeiro, 2006, Rev. psiquiatr. Rio Gd. Sul, V28, P186, DOI 10.1590/S0101-81082006000200011
   Tsigos C., 2020, Stress: Endocrine Physiology and Pathophysiology
   Tyring S, 2006, LANCET, V367, P29, DOI 10.1016/S0140-6736(05)67763-X
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
   Valtonen MK, 2012, SCAND J PUBLIC HEALT, V40, P674, DOI 10.1177/1403494812461730
   van Leijden MJ, 2018, SOC PSYCH PSYCH EPID, V53, P921, DOI 10.1007/s00127-018-1533-y
   Vanhala M, 2009, ACTA PSYCHIAT SCAND, V119, P137, DOI 10.1111/j.1600-0447.2008.01283.x
   Watson KT, 2021, AM J PSYCHIAT, V178, P914, DOI 10.1176/appi.ajp.2021.20101479
   Webb M, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0187448
   WEINSTEIN SP, 1995, DIABETES, V44, P441, DOI 10.2337/diabetes.44.4.441
   Weitz-Schmidt G, 2002, TRENDS PHARMACOL SCI, V23, P482, DOI 10.1016/S0165-6147(02)02077-1
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   WERNER H, 1989, ENDOCRINOLOGY, V125, P314, DOI 10.1210/endo-125-1-314
   Wirshing DA, 2004, J CLIN PSYCHIAT, V65, P13
   Wu XL, 2014, NEUROPSYCH DIS TREAT, V10, P1361, DOI 10.2147/NDT.S63140
   Yaribeygi H, 2017, EXCLI J, V16, P1057, DOI 10.17179/excli2017-480
   Yudkin JS, 1999, ARTERIOSCL THROM VAS, V19, P972, DOI 10.1161/01.ATV.19.4.972
   Zalli A, 2016, PSYCHOPHARMACOLOGY, V233, P1669, DOI 10.1007/s00213-015-3919-9
   Zambon A, 2005, ALIMENT PHARM THER, V22, P20, DOI 10.1111/j.1365-2036.2005.02589.x
NR 149
TC 33
Z9 33
U1 1
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2405-5808
J9 BIOCHEM BIOPHYS REP
JI Biochem. Biophys. Rep.
PD DEC
PY 2023
VL 36
AR 101571
DI 10.1016/j.bbrep.2023.101571
EA NOV 2023
PG 13
WC Biochemistry & Molecular Biology
WE Emerging Sources Citation Index (ESCI)
SC Biochemistry & Molecular Biology
GA Z1YS7
UT WOS:001110112300001
PM 37965066
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Carney, R
   Imran, S
   Law, H
   Firth, J
   Parker, S
AF Carney, Rebekah
   Imran, Shermin
   Law, Heather
   Firth, Joseph
   Parker, Sophie
TI Physical health interventions on adolescent mental health inpatient
   units: A systematic review and call to action
SO EARLY INTERVENTION IN PSYCHIATRY
LA English
DT Review
DE adolescent; health services; inpatient; physical health; review
ID CARDIOMETABOLIC RISK-FACTORS; ULTRA-HIGH RISK; METABOLIC SYNDROME;
   YOUNG-PEOPLE; LIFE-STYLE; OUTCOMES; SCHIZOPHRENIA; PSYCHOSIS; CHILDREN;
   ILLNESS
AB Aim Physical health inequalities experienced by people with mental health conditions are labelled an international scandal; due to the 15 to 30-year gap in life expectancy, driven mostly by physical health conditions. Lifestyle interventions are recommended to prevent the onset of poor physical health in people with mental illness. Yet, there is less high-quality evidence for adolescents, particularly those in inpatient settings. We aimed to assess existing literature reporting physical health or lifestyle interventions conducted on adolescent mental health inpatient units.
   Method An electronic search of MEDLINE, PsycINFO, Embase, the Cochrane Central Register of Controlled Trials and AMED was conducted on 13th June 2019. Eligible studies included peer-reviewed English language research articles of physical health interventions delivered within child and adolescent mental health inpatient services. A narrative synthesis was conducted on the data.
   Results Only three studies were identified implementing health interventions for adolescent inpatients. The interventions consisted of two physical health interventions aiming to increase activity levels within routine care (one gym-based, one sports led) and a yoga intervention. Outcome measurements varied and benefits were observed in relation to overall health (HONOSCA), physical health (waist, hip and chest circumference) and behaviour.
   Conclusions Although preliminary results suggest lifestyle interventions may be feasible and beneficial for this group, more work is needed to fully understand the best way to implement these interventions within adolescent clinical settings. Adolescent inpatients are an important target for such interventions, affording the opportunity to prevent the onset of physical comorbidities.
C1 [Carney, Rebekah; Law, Heather; Parker, Sophie] Greater Manchester Mental Hlth NHS Fdn Trust, Youth Mental Hlth Res Unit, Manchester, Lancs, England.
   [Carney, Rebekah; Firth, Joseph; Parker, Sophie] Univ Manchester, Div Psychol & Mental Hlth, Fac Biol Med & Hlth, Manchester, Lancs, England.
   [Imran, Shermin] Greater Manchester Mental Hlth NHS Fdn Trust, Child & Adolescent Mental Hlth Serv, Manchester, Lancs, England.
   [Firth, Joseph] Western Sydney Univ, NICM Hlth Res Inst, Sydney, NSW, Australia.
   [Firth, Joseph] Univ Melbourne, Ctr Youth Mental Hlth, Melbourne, Vic, Australia.
C3 University of Manchester; Western Sydney University; Orygen, The
   National Centre of Excellence in Youth Mental Health; University of
   Melbourne
RP Carney, R (corresponding author), Greater Manchester Mental Hlth NHS Fdn Trust, Youth Mental Hlth Res Unit, Rico House,Bury New Rd, Prestwich M13 3BL, England.
EM rebekah.carney@gmmh.nhs.uk
RI Firth, Joseph/JOZ-1679-2023; Carney, Rebekah/AAO-5205-2021
OI Parker, Sophie/0000-0001-5596-7524; Carney, Rebekah/0000-0002-2859-6825
FU FLF [MR/T021780/1] Funding Source: UKRI
CR [Anonymous], 2018, MANAGEMENT PHYS HLTH
   [Anonymous], 2018, [No title captured]
   Biddle SJH, 2019, PSYCHOL SPORT EXERC, V42, P146, DOI 10.1016/j.psychsport.2018.08.011
   Bobier C, 2009, INT J MENT HEALTH NU, V18, P301, DOI 10.1111/j.1447-0349.2009.00618.x
   Carney R, 2020, BJPSYCH BULL, V44, P95, DOI 10.1192/bjb.2019.68
   Carney R, 2018, EARLY INTERV PSYCHIA, V12, P153, DOI 10.1111/eip.12288
   Carney R, 2017, PSYCHIAT RES, V255, P87, DOI 10.1016/j.psychres.2017.05.023
   Carney R, 2016, SCHIZOPHR RES, V170, P290, DOI 10.1016/j.schres.2016.01.010
   Carter T, 2016, J PSYCHIATR MENT HLT, V23, P37, DOI 10.1111/jpm.12261
   Cordes J, 2017, SCHIZOPHR RES, V181, P38, DOI 10.1016/j.schres.2016.09.012
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   Craig Peter, 2008, BMJ, V337, pa1655, DOI 10.1136/bmj.a1655
   Curtis J, 2016, EARLY INTERV PSYCHIA, V10, P267, DOI 10.1111/eip.12230
   De Hert M, 2009, WORLD PSYCHIATRY, V8, P15
   Eapen V., 2012, J METABOLIC SYNDROME, V1, P2167
   Faulkner GEJ, 2009, PSYCHIAT SERV, V60, P538, DOI 10.1176/appi.ps.60.4.538
   Firth J, 2019, LANCET PSYCHIAT, V6, P675, DOI 10.1016/S2215-0366(19)30132-4
   Gnanavel S, 2018, WORLD J PSYCHIATR, V8, P27, DOI 10.5498/wjp.v8.i1.27
   Gorczynski P., 2013, CANADIAN J COMMUNITY, V32, P51, DOI DOI 10.7870/CJCMH-2013-024
   Gordon B, 2009, J PAEDIATR CHILD H, V45, P286, DOI 10.1111/j.1440-1754.2009.01493.x
   Gowers SG, 1999, BRIT J PSYCHIAT, V174, P413, DOI 10.1192/bjp.174.5.413
   Lederman O, 2017, PSYCHIAT RES, V257, P424, DOI 10.1016/j.psychres.2017.08.034
   Lubans DR, 2012, CHILD ADOL MENT H-UK, V17, P2, DOI 10.1111/j.1475-3588.2011.00623.x
   Malla A, 2016, SOC PSYCH PSYCH EPID, V51, P319, DOI 10.1007/s00127-015-1165-4
   McIlvain SJ, 2015, J PSYCHIATR MENT HLT, V22, P199, DOI 10.1111/jpm.12184
   Michie S, 2011, IMPLEMENT SCI, V6, DOI 10.1186/1748-5908-6-42
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   National Collaborating Center for Mental Health, 2014, Psychosis and schizophrenia in adults: Treatment and management
   Noetel M., 2016, Advances in Eating Disorders, V4, P262, DOI DOI 10.1080/21662630.2016.1202123
   Parker AG., 2018, EXERCISE BASED INTER, P149
   Pasha N., 2015, BMJ OPEN QUAL, V4
   Preyde M, 2018, J CAN ACAD CHILD ADO, V27, P191
   Public Health England, 2018, HLTH MATTERS REDUCIN
   Rickwood D, 2019, EARLY INTERV PSYCHIA, V13, P159, DOI 10.1111/eip.12740
   Sawyer SM, 2012, LANCET, V379, P1630, DOI 10.1016/S0140-6736(12)60072-5
   Shiers D, 2015, BRIT J PSYCHIAT, V207, P471, DOI 10.1192/bjp.bp.114.152595
   Spruit A, 2016, CLIN PSYCHOL REV, V45, P56, DOI 10.1016/j.cpr.2016.03.006
   Stubbs B, 2016, SCHIZOPHR RES, V176, P431, DOI 10.1016/j.schres.2016.05.017
   Swaby L, 2017, BJPSYCH BULL, V41, P137, DOI 10.1192/pb.bp.116.054304
   Thornicroft G, 2011, BRIT J PSYCHIAT, V199, P441, DOI 10.1192/bjp.bp.111.092718
   Tricco AC, 2018, ANN INTERN MED, V169, P467, DOI 10.7326/M18-0850
   van der Baan-Slootweg O, 2014, JAMA PEDIATR, V168, P807, DOI 10.1001/jamapediatrics.2014.521
   Vancampfort D, 2019, WORLD PSYCHIATRY, V18, P53, DOI 10.1002/wps.20614
   Vancampfort D, 2017, WORLD PSYCHIATRY, V16, P308, DOI 10.1002/wps.20458
   Wilson J, 2018, EARLY INTERV PSYCHIA, V12, P740, DOI 10.1111/eip.12452
   Woodhead G, 2018, EARLY INTERV PSYCHIA, V12, P734, DOI 10.1111/eip.12436
NR 46
TC 13
Z9 14
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1751-7885
EI 1751-7893
J9 EARLY INTERV PSYCHIA
JI Early Interv. Psychiatry
PD JUN
PY 2021
VL 15
IS 3
BP 439
EP 448
DI 10.1111/eip.12981
EA MAY 2020
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA RV7SA
UT WOS:000533624200001
PM 32426944
OA hybrid
DA 2025-06-11
ER

PT J
AU Puchner, E
   Platzer, M
   Dalkner, N
   Schwalsberger, K
   Lenger, M
   Fellendorf, FT
   Unterrainer, HF
   Schwerdtfeger, A
   Reininghaus, B
   Reininghaus, EZ
AF Puchner, Eva
   Platzer, Martina
   Dalkner, Nina
   Schwalsberger, Karin
   Lenger, Melanie
   Fellendorf, Frederike T.
   Unterrainer, Human-Friedrich
   Schwerdtfeger, Andreas
   Reininghaus, Bernd
   Reininghaus, Eva Z.
TI Effects of Metabolic Syndrome and Sex on Stress Coping Strategies in
   Individuals with Depressive Disorder
SO METABOLITES
LA English
DT Article
DE depression; stress coping strategies; metabolic syndrome; sex;
   distraction strategy
ID GENDER-DIFFERENCES; BIPOLAR DISORDER; RISK-FACTORS; METAANALYSIS;
   STYLES; MORTALITY; INSIGHTS; BEHAVIOR; OBESITY; PEOPLE
AB Metabolic syndrome (MetS) is related to depression and contributes to reduced life expectancy in individuals with mental disorders. Stress coping strategies are important factors in the development and maintenance of depressive disorders and have been related to metabolic disturbances. The aim of this study was to determine whether there is a difference in the use of positive (re- and devaluation, distraction, and control) and negative stress coping strategies in relation to patients' MetS. A sample of 363 individuals (n female = 204, n male = 159) with a diagnosis of depression was measured with the Stress Coping Style Questionnaire and the Beck Depression Inventory. In addition, we collected data on MetS (waist circumference, triglycerides, high-density lipoprotein, fasting glucose/diabetes, blood pressure/hypertonia) according to the International Diabetes Federation. A 2 x 2 design including Mets (with vs. without) and sex (female vs. male) was performed to test for differences in stress coping strategies. Individuals with depression and MetS scored higher on distraction strategies than depressed individuals without MetS (p < 0.01, corrected with false discovery rate). In addition, we found sex differences in stress coping strategies indicating that women with depression scored higher on distraction strategies (p < 0.001, FDR corrected), as well as negative strategies (p < 0.001, FDR corrected), than men. No significant interaction between MetS and sex was found regarding the higher value of stress coping strategies. Findings suggest that individuals with depression and MetS used distraction strategies to a higher amount to cope with stress, which could be stress eating in some cases, than those without MetS. Women with depressive disorders had higher values than men on other coping strategies in our sample of individuals with depression. A better understanding of MetS and sex-specific differences in stress coping strategies might help to plan more effective preventive strategies and personalized treatment options for depression.
C1 [Puchner, Eva; Unterrainer, Human-Friedrich; Schwerdtfeger, Andreas] Karl Franzens Univ Graz, Inst Psychol, A-8010 Graz, Austria.
   [Platzer, Martina; Dalkner, Nina; Schwalsberger, Karin; Lenger, Melanie; Fellendorf, Frederike T.; Unterrainer, Human-Friedrich; Reininghaus, Bernd; Reininghaus, Eva Z.] Med Univ Graz, Dept Psychiat & Psychotherapeut Med, A-8036 Graz, Austria.
   [Unterrainer, Human-Friedrich] Univ Vienna, Inst Religious Studies, A-1010 Vienna, Austria.
   [Unterrainer, Human-Friedrich] Gruner Kreis Soc, Ctr Integrat Addict Res CIAR, A-1110 Vienna, Austria.
   [Unterrainer, Human-Friedrich] Sigmund Freud Univ, Fac Psychotherapy Sci, A-1020 Vienna, Austria.
C3 University of Graz; Medical University of Graz; University of Vienna
RP Unterrainer, HF (corresponding author), Karl Franzens Univ Graz, Inst Psychol, A-8010 Graz, Austria.; Dalkner, N; Unterrainer, HF (corresponding author), Med Univ Graz, Dept Psychiat & Psychotherapeut Med, A-8036 Graz, Austria.; Unterrainer, HF (corresponding author), Univ Vienna, Inst Religious Studies, A-1010 Vienna, Austria.; Unterrainer, HF (corresponding author), Gruner Kreis Soc, Ctr Integrat Addict Res CIAR, A-1110 Vienna, Austria.; Unterrainer, HF (corresponding author), Sigmund Freud Univ, Fac Psychotherapy Sci, A-1020 Vienna, Austria.
EM nina.dalkner@medunigraz.at; human.unterrainer@univie.ac.at
RI Unterrainer, Human/JOQ-2781-2023; Schwerdtfeger, Andreas/U-5317-2019
OI Dalkner, Nina/0000-0001-7716-3674; Schwerdtfeger,
   Andreas/0000-0002-0371-3730; Unterrainer,
   Human-Friedrich/0000-0002-4815-0214; Reininghaus,
   Eva/0000-0001-5964-4087; Fellendorf, Frederike/0000-0001-7215-3848
FU University of Vienna
FX Open Access Funding by the University of Vienna.
CR Abdullah N.F., 2017, INT MED J, V24, P27
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Aldao A, 2010, CLIN PSYCHOL REV, V30, P217, DOI 10.1016/j.cpr.2009.11.004
   Alwerdt J., 2019, INNOV AGING, V3, pS955, DOI [10.1093/geroni/igz038.3466, DOI 10.1093/GERONI/IGZ038.3466]
   Anders I, 2000, Wien Med Wochenschr, V150, P25
   [Anonymous], 2015, Internationale Klassifikation psychischer Strungen: ICD-10 Kapitel V (F) Klinisch-diagnostische Leitlinien
   Baidog A., 2018, ANAL U ORADEA FASC E, V28, P39
   Baik I, 2008, AM J CLIN NUTR, V87, P1455, DOI 10.1093/ajcn/87.5.1455
   Bakan G, 2021, J CLIN NURS, V30, P874, DOI 10.1111/jocn.15633
   BENJAMINI Y, 1995, J R STAT SOC B, V57, P289, DOI 10.1111/j.2517-6161.1995.tb02031.x
   Bergmann N, 2014, ENDOCR CONNECT, V3, pR55, DOI 10.1530/EC-14-0031
   Billings A G, 1981, J Behav Med, V4, P139, DOI 10.1007/BF00844267
   Bonnet F, 2005, J HYPERTENS, V23, P611, DOI 10.1097/01.hjh.0000160219.71350.d2
   Cairns KE, 2014, J AFFECT DISORDERS, V169, P61, DOI 10.1016/j.jad.2014.08.006
   Meléndez JC, 2012, SPAN J PSYCHOL, V15, P1089, DOI 10.5209/rev_SJOP.2012.v15.n3.39399
   Casagrande M, 2019, STRESS HEALTH, V35, P560, DOI 10.1002/smi.2889
   Dalkner N, 2021, FRONT NEUROSCI-SWITZ, V15, DOI 10.3389/fnins.2021.717824
   Eaton R.J., 2008, INT J STRESS MANAGE, V15, P94, DOI [10.1037/1072-5245.15.1.94, DOI 10.1037/1072-5245.15.1.94]
   Erdmann G., 2008, Stressverarbeitungsfragebogen: SVF stress coping questionnaire: SVF; Measurement instrument
   Finch H., 2005, Methodology, V1, P27, DOI DOI 10.1027/1614-1881.1.1.27
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Gao WG, 2008, INT J OBESITY, V32, P757, DOI 10.1038/sj.ijo.0803797
   Greenberg PE, 2021, PHARMACOECONOMICS, V39, P653, DOI 10.1007/s40273-021-01019-4
   Hammen C, 2005, ANNU REV CLIN PSYCHO, V1, P293, DOI 10.1146/annurev.clinpsy.1.102803.143938
   Han KM, 2019, J AFFECT DISORDERS, V257, P486, DOI 10.1016/j.jad.2019.07.003
   Hill D, 2022, HEALTH PSYCHOL REV, V16, P280, DOI 10.1080/17437199.2021.1923406
   Hjellset VT, 2011, J IMMIGR MINOR HEALT, V13, P732, DOI 10.1007/s10903-010-9409-6
   Holubova M, 2017, EUR PSYCHIAT, V41, pS530, DOI 10.1016/j.eurpsy.2017.01.717
   Holubova M, 2018, NEUROPSYCH DIS TREAT, V14, P73, DOI 10.2147/NDT.S153115
   Hui WS, 2010, EUR J EPIDEMIOL, V25, P375, DOI 10.1007/s10654-010-9459-z
   Imaizumi T, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-22048-9
   Janke W., 2002, SVF 78. Eine Kurzform des Stressverabeitungsfragebogens SVF 120 [A short version of the Stress-Coping-Inventory 120]
   Johnson DP, 2013, PERS INDIV DIFFER, V55, P367, DOI 10.1016/j.paid.2013.03.019
   Kelly MAR, 2007, BRIT J CLIN PSYCHOL, V46, P315, DOI 10.1348/014466506X173070
   Kessler RC, 2005, ARCH GEN PSYCHIAT, V62, P593, DOI 10.1001/archpsyc.62.6.593
   Kühner C, 2007, NERVENARZT, V78, P651, DOI 10.1007/s00115-006-2098-7
   Kuo WC, 2019, OBES REV, V20, P1651, DOI 10.1111/obr.12915
   Kwarta Paulina, 2016, Pol Merkur Lekarski, V40, P301
   Lazarus R. S., 1984, STRESS APPRAISAL COP, DOI DOI 10.1002/PER.2410010304
   Lee YSC, 2012, INT J BEHAV MED, V19, P174, DOI 10.1007/s12529-011-9156-7
   Limon VM, 2020, QUAL LIFE RES, V29, P2063, DOI 10.1007/s11136-020-02479-5
   Lukasiewicz A, 2022, DIABET METAB SYND OB, V15, P407, DOI 10.2147/DMSO.S320909
   Matud MP, 2004, PERS INDIV DIFFER, V37, P1401, DOI 10.1016/j.paid.2004.01.010
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   MONROE SM, 1991, PSYCHOL BULL, V110, P406, DOI 10.1037/0033-2909.110.3.406
   Moradi Yousef, 2021, Clin Diabetes Endocrinol, V7, P4, DOI 10.1186/s40842-021-00117-8
   Mulvahill JS, 2017, J AM GERIATR SOC, V65, P2651, DOI 10.1111/jgs.15129
   Nagase Y, 2009, PSYCHIAT RES, V168, P57, DOI 10.1016/j.psychres.2008.03.024
   Orzechowska A, 2022, J CLIN MED, V11, DOI 10.3390/jcm11216500
   Puglisi-Allegra S, 2015, BEHAV BRAIN RES, V277, P58, DOI 10.1016/j.bbr.2014.07.052
   Razzoli M, 2017, NEUROSCI BIOBEHAV R, V76, P154, DOI 10.1016/j.neubiorev.2017.01.026
   Saboya PP, 2016, REV LAT-AM ENFERM, V24, DOI 10.1590/1518-8345.1573.2848
   Schlatter S, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-24905-z
   Silarova B, 2015, J PSYCHOSOM RES, V78, P391, DOI 10.1016/j.jpsychores.2015.02.010
   Slagter SN, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-195
   Tamres LK, 2002, PERS SOC PSYCHOL REV, V6, P2, DOI 10.1207/S15327957PSPR0601_1
   Taylor SE, 2007, ANNU REV CLIN PSYCHO, V3, P377, DOI 10.1146/annurev.clinpsy.3.022806.091520
   Tenk J, 2018, PSYCHONEUROENDOCRINO, V95, P63, DOI 10.1016/j.psyneuen.2018.05.014
   Torres SJ, 2007, NUTRITION, V23, P887, DOI 10.1016/j.nut.2007.08.008
   Van de Velde S, 2010, SOC SCI MED, V71, P305, DOI 10.1016/j.socscimed.2010.03.035
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Varela C, 2020, EAT WEIGHT DISORD-ST, V25, P1277, DOI 10.1007/s40519-019-00760-2
   Wang HH, 2020, PEDIATR GASTROENTERO, V23, P189
   who, WHO Depression
   Yancura LA, 2006, J GERONTOL B-PSYCHOL, V61, pP295, DOI 10.1093/geronb/61.5.P295
   Zellner DA, 2006, PHYSIOL BEHAV, V87, P789, DOI 10.1016/j.physbeh.2006.01.014
   Zhong YH, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-81653-2
NR 67
TC 1
Z9 1
U1 1
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD MAY 11
PY 2023
VL 13
IS 5
AR 652
DI 10.3390/metabo13050652
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA H5RF3
UT WOS:000996526400001
PM 37233693
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lin, H
   Liu, MX
   Zhong, DM
   Ng, EHY
   Liu, JP
   Li, J
   Shi, Y
   Zhang, CR
   Wen, XH
   Mai, ZF
   Ou, MX
   Ma, HX
AF Lin, Han
   Liu, Mingxing
   Zhong, Dongmei
   Ng, Ernest Hung Yu
   Liu, Jianping
   Li, Juan
   Shi, Yu
   Zhang, Chunren
   Wen, Xiaohui
   Mai, Zhefen
   Ou, Miaoxian
   Ma, Hongxia
TI The Prevalence and Factors Associated With Anxiety-Like and
   Depression-Like Behaviors in Women With Polycystic Ovary Syndrome
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE PCOS; anxiety; depression; hyperandrogenism; metabolic syndrome
ID QUALITY-OF-LIFE; SYNDROME PCOS; DIAGNOSTIC-CRITERIA; RISK; DISORDERS;
   METAANALYSIS; CONSENSUS; GLUCOSE; IMPACT
AB Increasing evidence shows that polycystic ovary syndrome (PCOS) patients are particularly vulnerable to anxiety/depression-like behaviors. This study sought to determine the prevalence of anxiety/depression-like behaviors among women with PCOS and to identify factors associated with these behaviors. This study was a secondary analysis of three studies performed on Chinese women who were aged 18 to 40 and diagnosed with PCOS according to the modified Rotterdam criteria. We obtained 802 useable responses for the self-rating anxiety scale and 798 responses for the self-rating depression scale. The prevalence of anxiety-like and depression-like behaviors among women with PCOS was 26.1% (209/802) and 52.0% (415/798), respectively. Anxiety-like behaviors were associated with age, body image-related factors (including body mass index and waist-to-hip ratio), and hyperandrogenism-related factors (including free androgen index and hirsutism). Depression-like behaviors were associated with age, body image-related factors, hyperandrogenism-related factors, and metabolic factors (including fasting insulin, fasting plasma glucose, and homeostatic model assessment of insulin resistance). Body image-related factors and hyperandrogenism-related factors were related to both anxiety-like behaviors and depression-like behaviors in both infertile and fertile PCOS patients.
C1 [Lin, Han; Li, Juan; Wen, Xiaohui; Mai, Zhefen; Ma, Hongxia] Guangzhou Med Univ, Affiliated Hosp 1, Dept Gynecol Tradit Chinese Med, Guangzhou, Peoples R China.
   [Liu, Mingxing; Shi, Yu; Ou, Miaoxian] Guangzhou Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 3, Guangzhou, Peoples R China.
   [Zhong, Dongmei] Guangzhou Med Univ, Dept Gynecol Tradit Chinese Med, Affiliated Hosp 3, Guangzhou, Peoples R China.
   [Ng, Ernest Hung Yu] Univ Hong Kong, Dept Obstet & Gynecol, Hong Kong, Peoples R China.
   [Liu, Jianping] Beijing Univ Chinese Med, Ctr Evidence Based Chinese Med, Beijing, Peoples R China.
   [Zhang, Chunren] Guangzhou Univ Chinese Med, Guangzhou, Peoples R China.
C3 Guangzhou Medical University; Guangzhou Medical University; Guangzhou
   Medical University; University of Hong Kong; Beijing University of
   Chinese Medicine; Guangzhou University of Chinese Medicine
RP Ma, HX (corresponding author), Guangzhou Med Univ, Affiliated Hosp 1, Dept Gynecol Tradit Chinese Med, Guangzhou, Peoples R China.
EM doctorhongxia@126.com
RI Mai, Zhefen/HJY-6446-2023; Zhang, Congyan/HHC-8442-2022
CR Anagnostis P, 2018, METABOLISM, V86, P33, DOI 10.1016/j.metabol.2017.09.016
   [Anonymous], 2016, Lancet, V388, P1459, DOI DOI 10.1016/s0140-6736(16)31678-6
   [Anonymous], 2017, 24WHOMSDMER20172
   Aslam M, 2021, J CLIN LIPIDOL, V15, P227, DOI 10.1016/j.jacl.2020.11.002
   Azziz R, 2018, OBSTET GYNECOL, V132, P321, DOI 10.1097/AOG.0000000000002698
   Barry JA, 2011, HUM REPROD, V26, P2442, DOI 10.1093/humrep/der197
   Barry JA, 2014, HUM REPROD UPDATE, V20, P748, DOI 10.1093/humupd/dmu012
   Bazarganipour F, 2015, INT J REPROD BIOMED, V13, P61
   Behboudi-Gandevani S, 2018, CLIN ENDOCRINOL, V88, P169, DOI 10.1111/cen.13477
   Blay SL, 2016, NEUROPSYCH DIS TREAT, V12, P2895, DOI 10.2147/NDT.S91700
   Brutocao C, 2018, ENDOCRINE, V62, P318, DOI 10.1007/s12020-018-1692-3
   Burke NL, 2015, J DEV BEHAV PEDIATR, V36, P133, DOI 10.1097/DBP.0000000000000143
   Chang J, 2004, FERTIL STERIL, V81, P19, DOI 10.1016/j.fertnstert.2003.10.004
   Çoban ÖG, 2019, J PEDIATR ADOL GYNEC, V32, P600, DOI 10.1016/j.jpag.2019.07.008
   Cooney LG, 2017, CURR PSYCHIAT REP, V19, DOI 10.1007/s11920-017-0834-2
   Cooney LG, 2017, HUM REPROD, V32, P1075, DOI 10.1093/humrep/dex044
   Dawes AJ, 2016, JAMA-J AM MED ASSOC, V315, P150, DOI 10.1001/jama.2015.18118
   Dumesic DA, 2015, ENDOCR REV, V36, P487, DOI 10.1210/er.2015-1018
   Dumont A, 2018, CURR OPIN ENDOCRINOL, V25, P377, DOI 10.1097/MED.0000000000000445
   Dunstan DA, 2018, DEPRESS RES TREAT, V2018, DOI [10.1155/2018/9250972, DOI 10.1155/2018/9250972]
   Ekbäck MP, 2013, DERMATOLOGY, V227, P278, DOI 10.1159/000355356
   Ezeh U, 2020, CLIN ENDOCRINOL, V93, P163, DOI 10.1111/cen.14193
   Fauser BCJM, 2012, FERTIL STERIL, V97, P28, DOI 10.1016/j.fertnstert.2011.09.024
   Murgel ACF, 2019, J SEX MED, V16, P542, DOI 10.1016/j.jsxm.2019.01.313
   Franik G, 2019, GYNECOL ENDOCRINOL, V35, P965, DOI 10.1080/09513590.2019.1613359
   Hollinrake E, 2007, FERTIL STERIL, V87, P1369, DOI 10.1016/j.fertnstert.2006.11.039
   Kahal H, 2017, CLIN ENDOCRINOL, V87, P313, DOI 10.1111/cen.13392
   Kakoly NS, 2018, HUM REPROD UPDATE, V24, P455, DOI 10.1093/humupd/dmy007
   Kakoly NS, 2019, DIABETES CARE, V42, P560, DOI 10.2337/dc18-1738
   Kogure GS, 2019, J AFFECT DISORDERS, V253, P385, DOI 10.1016/j.jad.2019.05.006
   Li H, 2016, J ENDOCRINOL INVEST, V39, P549, DOI 10.1007/s40618-015-0403-7
   Li J, 2017, TRIALS, V18, DOI 10.1186/s13063-017-1854-2
   Li J, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2015-010955
   Li R, 2013, HUM REPROD, V28, P2562, DOI 10.1093/humrep/det262
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Moghadam ZB, 2018, INT J WOMENS HEALTH, V10, P397, DOI 10.2147/IJWH.S165794
   Patel S, 2018, J STEROID BIOCHEM, V182, P27, DOI 10.1016/j.jsbmb.2018.04.008
   Picton HM, 2019, NAT MED, V25, P1818, DOI 10.1038/s41591-019-0678-x
   Podfigurna-Stopa A, 2015, GYNECOL ENDOCRINOL, V31, P431, DOI 10.3109/09513590.2015.1009437
   Rooney KL, 2018, DIALOGUES CLIN NEURO, V20, P41
   Rosenfield RL, 2016, ENDOCR REV, V37, P467, DOI 10.1210/er.2015-1104
   Teede H, 2010, BMC MED, V8, DOI 10.1186/1741-7015-8-41
   Torchen LC, 2017, CURR DIABETES REP, V17, DOI 10.1007/s11892-017-0956-2
   Veltman-Verhulst SM, 2012, HUM REPROD UPDATE, V18, P638, DOI 10.1093/humupd/dms029
   Wild RA, 2011, FERTIL STERIL, V95, P1073, DOI 10.1016/j.fertnstert.2010.12.027
   Yu HF, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000004863
   Zhang HY, 2013, ARCH GYNECOL OBSTET, V287, P525, DOI 10.1007/s00404-012-2568-z
   Zhao XM, 2011, EUR J OBSTET GYN R B, V154, P187, DOI 10.1016/j.ejogrb.2010.10.021
   Zheng YH, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2015-007757
   ZUNG WWK, 1971, PSYCHOSOMATICS, V12, P371
   ZUNG WWK, 1965, ARCH GEN PSYCHIAT, V12, P63, DOI 10.1001/archpsyc.1965.01720310065008
NR 51
TC 16
Z9 20
U1 5
U2 30
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD OCT 20
PY 2021
VL 12
AR 709674
DI 10.3389/fpsyt.2021.709674
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA WT6EX
UT WOS:000715957000001
PM 34744814
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Toker, S
   Shirom, A
   Shapira, I
   Berliner, S
   Melamed, S
AF Toker, Sharon
   Shirom, Arie
   Shapira, Itzhak
   Berliner, Shlomo
   Melamed, Samuel
TI The association between burnout, depression, anxiety, and inflammation
   biomarkers: C-reactive protein and fibrinogen in men and women
SO JOURNAL OF OCCUPATIONAL HEALTH PSYCHOLOGY
LA English
DT Review
ID CORONARY-HEART-DISEASE; ATHEROSCLEROTIC VASCULAR-DISEASE; HEALTH-CARE
   PROFESSIONALS; 3RD NATIONAL-HEALTH; RISK-FACTORS;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; VITAL EXHAUSTION;
   GLUCOCORTICOID SENSITIVITY; DISCRIMINANT VALIDITY
AB Following the demonstrated association of employee burnout or vital exhaustion with several risk factors for cardiovascular disease (CVD) and CVD risk, the authors investigated the possibility that one of the mechanisms linking burnout with CVD morbidity is microinflammation, gauged in this study by high-sensitivity C-reactive protein (hs-CRP) and fibrinogen concentrations. Their sample included 630 women and 933 men, all apparently healthy, who underwent periodic health examinations. The authors controlled for possible confounders including 2 other negative affective states: depression and anxiety. In women, burnout was positively associated with hs-CRP and fibrinogen concentrations, and anxiety was negatively associated with them. In men, depression was positively associated with hs-CRP and fibrinogen concentrations, but not with burnout or anxiety. Thus; burnout, depression, and anxiety are differentially associated with microinflammation biomarkers, dependent on gender.
C1 [Shirom, Arie] Tel Aviv Univ, Fac Management, IL-69978 Tel Aviv, Israel.
   [Shapira, Itzhak; Berliner, Shlomo] Tel Aviv Sourasky Med Ctr, Inst Special Med Examinat, Dept Med D, Tel Aviv, Israel.
   [Melamed, Samuel] Natl Inst Occupat & Environm Hlth, Dept Psychol, Raanana, Israel.
   [Melamed, Samuel] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel.
C3 Tel Aviv University; Tel Aviv University; Sackler Faculty of Medicine;
   Tel Aviv Sourasky Medical Center; Tel Aviv University; Sackler Faculty
   of Medicine
RP Toker, S (corresponding author), Tel Aviv Univ, Fac Management, IL-69978 Tel Aviv, Israel.
EM tokersha@post.tau.ac.il; ashirom@post.tau.ac.il
RI Toker, Sharon/P-5428-2015
OI Toker, Sharon/0000-0001-7621-6607
CR [Anonymous], 2003, Handbook of occupational health psychology, DOI [DOI 10.1037/10474-012, 10.1037/10474-012]
   Appels A, 2000, PSYCHOSOM MED, V62, P601, DOI 10.1097/00006842-200009000-00001
   APPELS A, 1991, BEHAV MED, V17, P53, DOI 10.1080/08964289.1991.9935158
   APPELS A, 1991, AM J CARDIOL, V68, P395, DOI 10.1016/0002-9149(91)90839-D
   APPELS A, 1988, TOPICS HLTH PSYCHOL, P31
   Babyak MA, 2004, PSYCHOSOM MED, V66, P411, DOI 10.1097/01.psy.0000127692.23278.a9
   Bargellini A, 2000, OCCUP ENVIRON MED, V57, P453, DOI 10.1136/oem.57.7.453
   Beaglehole R, 2002, INT J EPIDEMIOL, V31, P1117, DOI 10.1093/ije/31.6.1117
   Black PH, 2003, BRAIN BEHAV IMMUN, V17, P350, DOI 10.1016/S0889-1591(03)00048-5
   Black PH, 2002, BRAIN BEHAV IMMUN, V16, P622, DOI 10.1016/S0889-1591(02)00021-1
   Black PH, 2002, J PSYCHOSOM RES, V52, P1, DOI 10.1016/S0022-3999(01)00302-6
   BLUMENTHAL JA, 1979, J PSYCHOSOM RES, V23, P17, DOI 10.1016/0022-3999(79)90066-7
   Borella P, 1999, PSYCHONEUROENDOCRINO, V24, P613, DOI 10.1016/S0306-4530(99)00016-5
   Cacioppo J.T., 2000, Handbook of Emotions, P173
   Carinci F, 1997, EUR HEART J, V18, P835
   CHOW GC, 1960, ECONOMETRICA, V28, P591, DOI 10.2307/1910133
   CLAUSS A., 1957, ACTA HAEMATOL, V17, P237
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Corcos M, 2002, BIOMED PHARMACOTHER, V56, P105, DOI 10.1016/S0753-3322(01)00156-1
   CORDES CL, 1993, ACAD MANAGE REV, V18, P621, DOI 10.2307/258593
   CORRIGAN PW, 1994, J ORGAN BEHAV, V15, P65, DOI 10.1002/job.4030150107
   CORTINA JM, 1993, J MANAGE, V19, P915, DOI 10.1177/014920639301900411
   Danesh J, 2000, BMJ-BRIT MED J, V321, P199, DOI 10.1136/bmj.321.7255.199
   Danesh J, 1998, JAMA-J AM MED ASSOC, V279, P1477, DOI 10.1001/jama.279.18.1477
   Danner M, 2003, PSYCHOSOM MED, V65, P347, DOI 10.1097/01.PSY.0000041542.29808.01
   DASILVA JAP, 1992, BAILLIERE CLIN RHEUM, V6, P193, DOI 10.1016/S0950-3579(05)80344-9
   DAVIDSON RJ, 1994, NATURE EMOTIONS FUND, P261
   Demerouti E, 2001, J APPL PSYCHOL, V86, P499, DOI 10.1037//0021-9010.86.3.499
   Dietrich AJ, 2003, J AM BOARD FAM PRACT, V16, P107, DOI 10.3122/jabfm.16.2.107
   DINTENFASS L, 1975, BIBL HAEMATOL, P133
   Douglas KM, 2004, PSYCHOSOM MED, V66, P679, DOI 10.1097/01.psy.0000138132.66332.85
   Ezzati M, 2003, LANCET, V362, P271, DOI 10.1016/S0140-6736(03)13968-2
   Faxon DP, 2004, CIRCULATION, V109, P2595, DOI 10.1161/01.CIR.0000128517.52533.DB
   FEY GH, 1987, MOL BIOL MED, V4, P323
   FOLSOM AR, 1993, AM J EPIDEMIOL, V138, P1023, DOI 10.1093/oxfordjournals.aje.a116821
   Ford DE, 2004, ARCH INTERN MED, V164, P1010, DOI 10.1001/archinte.164.9.1010
   Franssen PML, 2003, J PSYCHOSOM RES, V54, P339, DOI 10.1016/S0022-3999(02)00395-1
   Freeman DJ, 2002, DIABETES, V51, P1596, DOI 10.2337/diabetes.51.5.1596
   French JR., 1982, MECH JOB STRESS STRA, V7
   Gabay C, 1999, NEW ENGL J MED, V340, P448, DOI 10.1056/NEJM199902113400607
   Glass DC, 1996, PSYCHOL HEALTH, V11, P23, DOI 10.1080/08870449608401975
   Gorter RC, 2000, EUR J ORAL SCI, V108, P261, DOI 10.1034/j.1600-0722.2000.108004261.x
   Grossi G, 2003, J PSYCHOSOM RES, V55, P309, DOI 10.1016/S0022-3999(02)00633-5
   Hackam DG, 2003, JAMA-J AM MED ASSOC, V290, P932, DOI 10.1001/jama.290.7.932
   Halford C, 2003, J PSYCHOSOM RES, V55, P317, DOI 10.1016/S0022-3999(02)00634-7
   Hallman T, 2003, J HEALTH PSYCHOL, V8, P433, DOI 10.1177/13591053030084003
   Hallman T, 2001, J CARDIOVASC RISK, V8, P39, DOI 10.1097/00043798-200102000-00006
   Hemingway H, 1999, BMJ-BRIT MED J, V318, P1460, DOI 10.1136/bmj.318.7196.1460
   Hennekens CH, 1998, CIRCULATION, V97, P1095, DOI 10.1161/01.CIR.97.11.1095
   Herrick S, 1999, INT J BIOCHEM CELL B, V31, P741, DOI 10.1016/S1357-2725(99)00032-1
   Herrmann C, 2000, J PSYCHOSOM RES, V48, P455, DOI 10.1016/S0022-3999(99)00086-0
   Hu FB, 2004, DIABETES, V53, P693, DOI 10.2337/diabetes.53.3.693
   Jackson S., 1986, Maslach Burnout Inventory Manual, V2nd
   Jeanmonod P, 2004, PSYCHOSOM MED, V66, P501, DOI 10.1097/01.psy.0000130903.78444.7d
   Jilma B, 1997, J LAB CLIN MED, V130, P69, DOI 10.1016/S0022-2143(97)90060-3
   Joynt KE, 2004, J CARD FAIL, V10, P258, DOI 10.1016/j.cardfail.2003.09.008
   KAHILL S, 1988, CAN PSYCHOL, V29, P284, DOI 10.1037/h0079772
   Kiecolt-Glaser JK, 2002, ANNU REV PSYCHOL, V53, P83, DOI 10.1146/annurev.psych.53.100901.135217
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Kittel F, 2002, EUR HEART J, V23, P1841, DOI 10.1053/euhj.2002.3258
   Koenig W, 2001, Cardiol Rev, V9, P31, DOI 10.1097/00045415-200101000-00007
   Koh KB, 1998, J PSYCHOSOM RES, V45, P107, DOI 10.1016/S0022-3999(97)00292-4
   Koh KB, 1998, PSYCHOSOM MED, V60, P479, DOI 10.1097/00006842-199807000-00015
   Konsman JP, 2002, TRENDS NEUROSCI, V25, P154, DOI 10.1016/S0166-2236(00)02088-9
   Kop WJ, 2003, BRAIN BEHAV IMMUN, V17, P233, DOI 10.1016/S0889-1591(03)00051-5
   Kop WJ, 2002, AM J CARDIOL, V89, P419, DOI 10.1016/S0002-9149(01)02264-0
   Kop WJ, 1998, PSYCHOSOM MED, V60, P352, DOI 10.1097/00006842-199805000-00023
   Krantz DS, 2002, ANNU REV PSYCHOL, V53, P341, DOI 10.1146/annurev.psych.53.100901.135208
   Kring AM, 1998, J PERS SOC PSYCHOL, V74, P686, DOI 10.1037/0022-3514.74.3.686
   Kubzansky LD, 1998, ANN BEHAV MED, V20, P47, DOI 10.1007/BF02884448
   Kubzansky LD, 2000, J PSYCHOSOM RES, V48, P323, DOI 10.1016/S0022-3999(99)00091-4
   Kuper Hannah, 2002, Semin Vasc Med, V2, P267, DOI 10.1055/s-2002-35401
   Ladwig KH, 2003, BRAIN BEHAV IMMUN, V17, P268, DOI 10.1016/S0889-1591(03)00056-4
   Lahita RG, 1997, INT J FERTIL WOMEN M, V42, P115
   LEITER MP, 1994, ANXIETY STRESS COPIN, V7, P357, DOI 10.1080/10615809408249357
   Lerman Y, 1999, PSYCHOSOM MED, V61, P828, DOI 10.1097/00006842-199911000-00017
   Libby P, 2004, AM J MED, V116, P1, DOI 10.1016/j.amjmed.2004.02.004
   Libby P, 2002, CIRCULATION, V105, P1135, DOI 10.1161/hc0902.104353
   Lubetkin EI, 2003, AM J PREV MED, V24, P354, DOI 10.1016/S0749-3797(03)00017-5
   Maier SF, 1998, PSYCHOL REV, V105, P83, DOI 10.1037/0033-295X.105.1.83
   Maslach C, 2001, ANNU REV PSYCHOL, V52, P397, DOI 10.1146/annurev.psych.52.1.397
   MATTIASSON I, 1993, J INTERN MED, V234, P45, DOI 10.1111/j.1365-2796.1993.tb00703.x
   McCaffery JM, 2003, PSYCHOSOM MED, V65, P490, DOI 10.1097/01.PSY.0000041545.52924.82
   Melamed S, 1999, J PSYCHOSOM RES, V46, P591, DOI 10.1016/S0022-3999(99)00007-0
   MELAMED S, 1992, BEHAV MED, V18, P53, DOI 10.1080/08964289.1992.9935172
   Melamed S., 2003, BURNOUT RISK TYPE 2
   Miller GE, 2002, AM J CARDIOL, V90, P1279, DOI 10.1016/S0002-9149(02)02863-1
   Miller GE, 2003, BRAIN BEHAV IMMUN, V17, P276, DOI 10.1016/S0889-1591(03)00057-6
   Nease DE, 2003, J FAM PRACTICE, V52, P118
   Panagiotakos DB, 2004, EUR HEART J, V25, P492, DOI 10.1016/j.ehj.2004.01.018
   Papanicolaou DA, 1998, ANN INTERN MED, V128, P127, DOI 10.7326/0003-4819-128-2-199801150-00009
   Pearson TA, 2003, CIRCULATION, V107, P499, DOI 10.1161/01.CIR.0000052939.59093.45
   Penninx BWJH, 2003, BIOL PSYCHIAT, V54, P566, DOI 10.1016/S0006-3223(02)01811-5
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Raikkonen K, 1996, ARTERIOSCL THROM VAS, V16, P363, DOI 10.1161/01.ATV.16.3.363
   Reichenberg A, 2001, ARCH GEN PSYCHIAT, V58, P445, DOI 10.1001/archpsyc.58.5.445
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   Ridker PM, 2004, AM HEART J, V148, pS19, DOI 10.1016/j.ahj.2004.04.028
   Ridker PM, 2003, CIRCULATION, V108, pE81, DOI 10.1161/01.CIR.0000093381.57779.67
   Ridker PM, 2004, CIRCULATION, V109, P2818, DOI 10.1161/01.CIR.0000132467.45278.59
   Ridker PM, 2004, CIRCULATION, V109, P1955, DOI 10.1161/01.CIR.0000125690.80303.A8
   Ridker PM, 2002, NEW ENGL J MED, V347, P1557, DOI 10.1056/NEJMoa021993
   Ridker PM, 2000, NEW ENGL J MED, V342, P836, DOI 10.1056/NEJM200003233421202
   Rifai N, 1999, CLIN CHEM, V45, P2136
   Rifai N, 2003, CLIN CHEM, V49, P666, DOI 10.1373/49.4.666
   Rogowski O, 2004, BIOMARKERS, V9, P85, DOI 10.1080/13547500410001670303
   Rohleder N, 2001, PSYCHOSOM MED, V63, P966, DOI 10.1097/00006842-200111000-00016
   Rosenthal R., 2000, Contrasts and Effect Sizes in Behavioral Research: A Correlational Approach
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Rozanski A, 1999, CIRCULATION, V99, P2192, DOI 10.1161/01.CIR.99.16.2192
   Rugulies R, 2002, AM J PREV MED, V23, P51, DOI 10.1016/S0749-3797(02)00439-7
   Ryff CD, 2003, SER AFFECTIVE SCI, P1083
   Sattar N, 2003, CIRCULATION, V108, P414, DOI 10.1161/01.CIR.0000080897.52664.94
   Schaufeli W., 1998, The burnout companion to study and practice: A critical analysis, V1st, DOI 10.1201/9781003062745
   Schaufeli W.B., 2003, Handbook of work and health psychology, V2nd, P383, DOI [10.1002/0470013400.ch19, DOI 10.1002/0470013400.CH19]
   Sesso HD, 2003, JAMA-J AM MED ASSOC, V290, P2945, DOI 10.1001/jama.290.22.2945
   Sheiner EK, 2002, J OCCUP ENVIRON MED, V44, P1093, DOI 10.1097/00043764-200212000-00001
   Shirom A, 1997, J Occup Health Psychol, V2, P275, DOI 10.1037/1076-8998.2.4.275
   Shirom A, 2003, ANXIETY STRESS COPIN, V16, P83, DOI 10.1080/1061580021000057059
   Shirom A., 1989, International review of industrial and organizational psychology, P25
   SHIROM A, 2005, NEW PERSPECTIVES OCC, V20, P269
   Shirom A., 2005, SHIROM MELAMED BURNO
   SPITZER RL, 1994, JAMA-J AM MED ASSOC, V272, P1749, DOI 10.1001/jama.272.22.1749
   Spitzer RL, 1999, JAMA-J AM MED ASSOC, V282, P1737, DOI 10.1001/jama.282.18.1737
   *STAT ISR MIN HLTH, 2001, HLTH ISR 2001 SEL DA
   Steptoe A, 2002, BRAIN BEHAV IMMUN, V16, P774, DOI 10.1016/S0889-1591(02)00030-2
   Strike PC, 2004, PROG CARDIOVASC DIS, V46, P337, DOI 10.1016/j.pcad.2003.09.001
   Theorell T, 2002, EUR HEART J, V23, P1799, DOI 10.1053/euhj.2002.3293
   Toker S, 2005, DIABETES-METAB RES, V21, P197, DOI 10.1002/dmrr.502
   Tsutsumi A, 1999, J EPIDEMIOL COMMUN H, V53, P348, DOI 10.1136/jech.53.6.348
   van Diest R, 2002, PSYCHOSOM MED, V64, P787, DOI 10.1097/01.PSY.0000021953.59258.55
   VANDIEST R, 1991, J PSYCHOSOM RES, V35, P535, DOI 10.1016/0022-3999(91)90048-S
   Verma S, 2004, CIRCULATION, V109, P1914, DOI 10.1161/01.CIR.0000127085.32999.64
   von Känel R, 2004, SCAND CARDIOVASC J, V38, P28, DOI 10.1080/14017430310015884
   von Känel R, 2001, PSYCHOSOM MED, V63, P531, DOI 10.1097/00006842-200107000-00003
   Vorster HH, 1999, THROMB RES, V95, P137, DOI 10.1016/S0049-3848(99)00033-X
   Weaver JD, 2002, NEUROLOGY, V59, P371, DOI 10.1212/WNL.59.3.371
   Wilder RL, 1998, ANN NY ACAD SCI, V840, P45, DOI 10.1111/j.1749-6632.1998.tb09547.x
   Wilson CJ, 2002, J AM GERIATR SOC, V50, P2041, DOI 10.1046/j.1532-5415.2002.50619.x
   Wirtz PH, 2003, PSYCHOSOM MED, V65, P672, DOI 10.1097/01.PSY.0000062529.39901.C7
   Wojciechowski FL, 2000, ACTA PSYCHIAT SCAND, V102, P359, DOI 10.1034/j.1600-0447.2000.102005359.x
NR 142
TC 224
Z9 272
U1 0
U2 40
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 1076-8998
EI 1939-1307
J9 J OCCUP HEALTH PSYCH
JI J. Occup. Health Psychol.
PD OCT
PY 2005
VL 10
IS 4
BP 344
EP 362
DI 10.1037/1076-8998.10.4.344
PG 19
WC Public, Environmental & Occupational Health; Psychology, Applied
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Psychology
GA V43VT
UT WOS:000202963300005
PM 16248685
DA 2025-06-11
ER

PT J
AU Goldstein, JM
   Holsen, L
   Huang, G
   Hammond, BD
   James-Todd, T
   Cherkerzian, S
   Hale, TM
   Handa, RJ
AF Goldstein, Jill M.
   Holsen, Laura
   Huang, Grace
   Hammond, Bradley D.
   James-Todd, Tamarra
   Cherkerzian, Sara
   Hale, Taben M.
   Handa, Robert J.
TI Prenatal stress-immune programming of sex differences in comorbidity of
   depression and obesity/metabolic syndrome
SO DIALOGUES IN CLINICAL NEUROSCIENCE
LA English
DT Article
DE depression; depression-cardiometabolic comorbidity; fetal programming;
   inflammation; obesity/metabolic syndrome; prenatal stress model; sex
   difference
ID PITUITARY-ADRENAL AXIS; ESTROGEN-RECEPTOR-ALPHA; PARAVENTRICULAR
   NUCLEUS; HIPPOCAMPAL VOLUME; HUMAN HYPOTHALAMUS; STEROID-HORMONES;
   IN-VIVO; GLUCOCORTICOID TREATMENT; ANTENATAL BETAMETHASONE;
   INSULIN-RESISTANCE
AB Major depressive disorder (MDD) is the number one cause of disability worldwide and is comorbid with many chronic diseases, including obesity/metabolic syndrome (MetS). Women have twice as much risk for MDD and comorbidity with obesity/MetS as men, although pathways for understanding this association remain unclear. On the basis of clinical and preclinical studies, we argue that prenatal maternal stress (ie, excess glucocorticoid expression and associated immune responses) that occurs during the sexual differentiation of the fetal brain has sex-dependent effects on brain development within highly sexually dimorphic regions that regulate mood, stress, metabolic function, the autonomic nervous system, and the vasculature. Furthermore, these effects have lifelong consequences for shared sex-dependent risk of MDD and obesity/MetS. Thus, we propose that there are shared biologic substrates at the anatomical, molecular, and/or genetic levels that produce the comorbid risk for MDD-MetS through sex-dependent fetal origins. (C) 2016, AICH - Servier Research Group
C1 [Goldstein, Jill M.; Holsen, Laura; James-Todd, Tamarra; Cherkerzian, Sara] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Connors Ctr Womens Hlth & Gender Biol, Boston, MA USA.
   [Goldstein, Jill M.; Holsen, Laura; Cherkerzian, Sara] Harvard Med Sch, Dept Psychiat, Boston, MA USA.
   [Goldstein, Jill M.; Holsen, Laura; Cherkerzian, Sara] Harvard Med Sch, Dept Med, Boston, MA USA.
   [Huang, Grace] Brigham & Womens Hosp, Dept Med, Div Endocrinol, 75 Francis St, Boston, MA 02115 USA.
   [Hammond, Bradley D.; Hale, Taben M.; Handa, Robert J.] Univ Arizona, Coll Med Phoenix, Dept Basic Med Sci, Phoenix, AZ USA.
   [Hammond, Bradley D.; Handa, Robert J.] Colorado State Univ, Dept Biomed Sci, Ft Collins, CO 80523 USA.
   [James-Todd, Tamarra] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School; Harvard University; Harvard
   Medical School; Harvard University; Harvard Medical School; Harvard
   University; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; University of Arizona; Colorado State University System;
   Colorado State University Fort Collins; Harvard University; Harvard T.H.
   Chan School of Public Health
RP Goldstein, JM (corresponding author), Brigham & Womens Hosp, Div Womens Hlth, Connors Ctr, One Brigham Circle,1620 Tremont St, Boston, MA 02120 USA.
EM jill_goldstein@hms.harvard.edu
RI Cherkerzian, Sara/MHQ-2272-2025; Holsen, Laura/I-9186-2014
OI Holsen, Laura/0000-0003-1292-7789; Hale, Taben/0000-0002-5066-1216
FU State of Arizona Arizona Biomedical Research Commission (ABRC)
   [ADHS14-00003606]
FX The work for this article was supported by a program project grant from
   the State of Arizona Arizona Biomedical Research Commission (ABRC)
   ADHS14-00003606 (Handa, overall PI; Goldstein, PI, human studies). We
   would like to thank Stuart Tobet, PhD for previous work with us on the
   topic of comorbidity of depression and CVD that forms the basis of some
   of the scientific framework in this review. The authors report no
   conflict of interest.
CR Ahmed ML, 1999, J CLIN ENDOCR METAB, V84, P899, DOI 10.1210/jc.84.3.899
   Angold A, 2006, CHILD ADOL PSYCH CL, V15, P919, DOI 10.1016/j.chc.2006.05.013
   [Anonymous], 2014, Global Health Estimates Summary Tables: Deaths by cause, age and sex
   Arnone D, 2016, HUM BRAIN MAPP, V37, P1393, DOI 10.1002/hbm.23108
   Attig L, 2008, INT J OBESITY, V32, P1153, DOI 10.1038/ijo.2008.39
   Bao AM, 2005, BRAIN, V128, P1301, DOI 10.1093/brain/awh448
   Barim AO, 2009, CLIN BIOCHEM, V42, P1076, DOI 10.1016/j.clinbiochem.2009.02.020
   BAYER SA, 1993, NEUROTOXICOLOGY, V14, P83
   Beltrán-Sánchez H, 2013, J AM COLL CARDIOL, V62, P697, DOI 10.1016/j.jacc.2013.05.064
   Benson S, 2009, PSYCHONEUROENDOCRINO, V34, P181, DOI 10.1016/j.psyneuen.2008.08.019
   Bhatnagar S, 2005, HORM BEHAV, V47, P430, DOI 10.1016/j.yhbeh.2004.11.019
   Bogdarina I, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009237
   Bose M, 2009, CURR OPIN ENDOCRINOL, V16, P340, DOI 10.1097/MED.0b013e32832fa137
   Bouret SG, 2009, J PEDIATR GASTR NUTR, V48, pS31, DOI 10.1097/MPG.0b013e3181977375
   Bouret SG, 2004, J NEUROSCI, V24, P2797, DOI 10.1523/JNEUROSCI.5369-03.2004
   Boyne MS, 2010, DIABETES RES CLIN PR, V90, pE33, DOI 10.1016/j.diabres.2010.08.008
   Briana DD, 2010, ANN NY ACAD SCI, V1205, P82, DOI 10.1111/j.1749-6632.2010.05650.x
   Brummelte S, 2010, PROG NEURO-PSYCHOPH, V34, P766, DOI 10.1016/j.pnpbp.2009.09.006
   Brunton PJ, 2015, J NEUROSCI, V35, P666, DOI 10.1523/JNEUROSCI.5104-13.2015
   Bujalska IJ, 1999, ENDOCRINOLOGY, V140, P3188, DOI 10.1210/en.140.7.3188
   Campbell S, 2004, AM J PSYCHIAT, V161, P598, DOI 10.1176/appi.ajp.161.4.598
   Carbone DL, 2012, ENDOCRINOLOGY, V153, P295, DOI 10.1210/en.2011-1601
   Cleasby ME, 2003, ENDOCRINOLOGY, V144, P999, DOI 10.1210/en.2002-220559
   Cole J, 2011, J AFFECT DISORDERS, V134, P483, DOI 10.1016/j.jad.2011.05.057
   Cottrell EC, 2014, ACTA PHYSIOL, V210, P288, DOI 10.1111/apha.12187
   Cottrell EC, 2009, FRONT BEHAV NEUROSCI, V3, DOI 10.3389/neuro.08.019.2009
   Croizier S, 2016, CELL REP, V15, P36, DOI 10.1016/j.celrep.2016.02.088
   Crudo A, 2012, ENDOCRINOLOGY, V153, P3269, DOI 10.1210/en.2011-2160
   Cuffe JSM, 2016, PHYSIOL REP, V4, DOI 10.14814/phy2.12754
   Cummings DE, 2001, DIABETES, V50, P1714, DOI 10.2337/diabetes.50.8.1714
   Dagan A, 2010, AM J HYPERTENS, V23, P420, DOI 10.1038/ajh.2009.274
   Daly RC, 2003, AM J PSYCHIAT, V160, P1842, DOI 10.1176/appi.ajp.160.10.1842
   De Pergola G, 2006, OBESITY, V14, P1954, DOI 10.1038/oby.2006.228
   DEFRONZO RA, 1991, DIABETES CARE, V14, P173, DOI 10.2337/diacare.14.3.173
   Derby CA, 2006, CLIN ENDOCRINOL, V65, P125, DOI 10.1111/j.1365-2265.2006.02560.x
   Dodic M, 2006, J PHYSIOL-LONDON, V571, P651, DOI 10.1113/jphysiol.2005.102186
   Donahue RP, 2007, DIABETES CARE, V30, P354, DOI 10.2337/dc06-1772
   Dougherty D, 1997, HARVARD REV PSYCHIAT, V5, P138, DOI 10.3109/10673229709000299
   Drake AJ, 2010, ENDOCRINOLOGY, V151, P1581, DOI 10.1210/en.2009-1088
   Drevets WC, 2002, PHARMACOL BIOCHEM BE, V71, P431, DOI 10.1016/S0091-3057(01)00687-6
   Dumortier O, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025576
   Epperson CN, 1999, PSYCHOSOM MED, V61, P676, DOI 10.1097/00006842-199909000-00010
   Eskola PJ, 2015, AM J PSYCHIAT, V172, P796, DOI 10.1176/appi.ajp.2015.15030377
   Fernández-Real JM, 1999, CLIN ENDOCRINOL, V50, P253
   Frahm KA, 2012, HORM METAB RES, V44, P619, DOI 10.1055/s-0032-1304624
   Garza JC, 2008, J BIOL CHEM, V283, P18238, DOI 10.1074/jbc.M800053200
   Gelernter-Yaniv L, 2003, INT J OBESITY, V27, P983, DOI 10.1038/sj.ijo.0802327
   Giedd JN, 1996, J COMP NEUROL, V366, P223, DOI 10.1002/(SICI)1096-9861(19960304)366:2<223::AID-CNE3>3.0.CO;2-7
   Gilman SE, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.91
   Goldstein JM, 2014, FRONT NEUROENDOCRIN, V35, P140, DOI 10.1016/j.yfrne.2013.12.001
   Goldstein JM, 2011, J DEV ORIG HLTH DIS, V2, P353, DOI 10.1017/S2040174411000651
   Goldstein JM, 2014, FRONT NEUROSCI-SWITZ, V8, DOI 10.3389/fnins.2014.00247
   Goldstein JM, 2010, J NEUROSCI, V30, P431, DOI 10.1523/JNEUROSCI.3021-09.2010
   Goldstein JM, 2001, CEREB CORTEX, V11, P490, DOI 10.1093/cercor/11.6.490
   Graziottin Alessandra, 2009, Menopause Int, V15, P76, DOI 10.1258/mi.2009.009021
   Gwathmey TM, 2011, HYPERTENSION, V57, P620, DOI 10.1161/HYPERTENSIONAHA.110.164970
   Hadoke PWF, 2006, J ENDOCRINOL, V188, P435, DOI 10.1677/joe.1.06506
   Haggerty CL, 2005, AM J OBSTET GYNECOL, V193, P209, DOI 10.1016/j.ajog.2004.11.008
   Hamilton JP, 2008, MOL PSYCHIATR, V13, P993, DOI 10.1038/mp.2008.57
   HANDA RJ, 1994, HORM BEHAV, V28, P464, DOI 10.1006/hbeh.1994.1044
   Handa RJ, 2014, FRONT NEUROENDOCRIN, V35, P197, DOI 10.1016/j.yfrne.2013.11.001
   Harlow BL, 2003, ARCH GEN PSYCHIAT, V60, P29, DOI 10.1001/archpsyc.60.1.29
   Harris A, 2011, HORM BEHAV, V59, P279, DOI 10.1016/j.yhbeh.2010.06.007
   Hasler G, 2005, MOL PSYCHIATR, V10, P842, DOI 10.1038/sj.mp.4001671
   HENRY C, 1994, J NEUROENDOCRINOL, V6, P341, DOI 10.1111/j.1365-2826.1994.tb00591.x
   Heo M, 2006, INT J OBESITY, V30, P513, DOI 10.1038/sj.ijo.0803122
   Hiroi R, 2016, NEUROSCIENCE, V320, P43, DOI 10.1016/j.neuroscience.2016.01.055
   Holmes MC, 2015, PSYCHONEUROENDOCRINO, V61, P9, DOI 10.1016/j.psyneuen.2015.07.411
   HOLSBOER F, 1987, AM J PSYCHIAT, V144, P229
   Howerton CL, 2014, P NATL ACAD SCI USA, V111, P9639, DOI 10.1073/pnas.1401203111
   Howerton CL, 2013, P NATL ACAD SCI USA, V110, P5169, DOI 10.1073/pnas.1300065110
   Hryhorczuk C, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00177
   Igosheva N, 2004, J PHYSIOL-LONDON, V557, P273, DOI 10.1113/jphysiol.2003.056911
   Igosheva N, 2007, J PHYSIOL-LONDON, V582, P665, DOI 10.1113/jphysiol.2007.130252
   Jacobs EG, 2015, NEUROPSYCHOPHARMACOL, V40, P566, DOI 10.1038/npp.2014.203
   James-Todd TM, 2016, ENVIRON HEALTH-GLOB, V15, DOI 10.1186/s12940-016-0136-x
   Janssen I, 2010, OBESITY, V18, P604, DOI 10.1038/oby.2009.251
   Karim R, 2015, J CLIN ENDOCR METAB, V100, P508, DOI 10.1210/jc.2014-1839
   Kawata M, 1995, NEUROSCI RES, V24, P1, DOI 10.1016/0168-0102(96)81278-8
   KELLY WF, 1980, BRIT J PSYCHIAT, V136, P125, DOI 10.1192/bjp.136.2.125
   Kempton MJ, 2011, ARCH GEN PSYCHIAT, V68, P675, DOI 10.1001/archgenpsychiatry.2011.60
   Kloiber S, 2007, BIOL PSYCHIAT, V62, P321, DOI 10.1016/j.biopsych.2006.10.001
   Kluge M, 2009, NEUROPSYCHOBIOLOGY, V59, P199, DOI 10.1159/000223731
   Koolschijn PCMP, 2009, HUM BRAIN MAPP, V30, P3719, DOI 10.1002/hbm.20801
   Korbonits M, 1997, CLIN ENDOCRINOL, V46, P751, DOI 10.1046/j.1365-2265.1997.1820979.x
   Kruijver FPM, 2003, J COMP NEUROL, V466, P251, DOI 10.1002/cne.10899
   Kruijver FPM, 2002, J COMP NEUROL, V454, P115, DOI 10.1002/cne.10416
   Lee JH, 2013, AM J PHYSIOL-REG I, V304, pR581, DOI 10.1152/ajpregu.00579.2012
   Libby P, 2002, CIRCULATION, V105, P1135, DOI 10.1161/hc0902.104353
   LING MHM, 1981, ARCH GEN PSYCHIAT, V38, P471
   Liu J, 2012, P NATL ACAD SCI USA, V109, P12248, DOI 10.1073/pnas.1202835109
   Maccari S, 2003, NEUROSCI BIOBEHAV R, V27, P119, DOI 10.1016/S0149-7634(03)00014-9
   Makris N, 2013, NEUROIMAGE, V69, P1, DOI 10.1016/j.neuroimage.2012.12.008
   Malik S, 2008, CELL METAB, V7, P400, DOI 10.1016/j.cmet.2008.03.007
   Marshall AC, 2013, PEPTIDES, V44, P25, DOI 10.1016/j.peptides.2013.03.018
   Mayberg HS, 1997, J NEUROPSYCH CLIN N, V9, P471
   McClellan KM, 2010, J COMP NEUROL, V518, P2710, DOI 10.1002/cne.22360
   MCCORMICK CM, 1995, DEV BRAIN RES, V84, P55, DOI 10.1016/0165-3806(94)00153-Q
   MCEWEN BS, 1983, INT REV PHYSIOL, V27, P99
   MCEWEN BS, 1986, PHYSIOL REV, V66, P1121, DOI 10.1152/physrev.1986.66.4.1121
   McKinnon MC, 2009, J PSYCHIATR NEUROSCI, V34, P41
   Mela V, 2015, ENDOCRINOLOGY, V156, P2571, DOI 10.1210/en.2014-1981
   Mirhafez SR, 2015, BRIT J NUTR, V113, P1911, DOI 10.1017/S0007114515001038
   Moritz KM, 2009, CLIN EXP PHARMACOL P, V36, P981, DOI 10.1111/j.1440-1681.2009.05180.x
   Mozaffarian D, 2015, CIRCULATION, V131, pE29, DOI 10.1161/CIR.0000000000000152
   Murphy JM, 2009, INT J OBESITY, V33, P335, DOI 10.1038/ijo.2008.273
   Mystkowski P, 2000, NUTRITION, V16, P937, DOI 10.1016/S0899-9007(00)00458-5
   Naghavi M, 2003, CIRCULATION, V107, P762, DOI 10.1161/01.CIR.0000048190.68071.2B
   Nakazato M, 2001, NATURE, V409, P194, DOI 10.1038/35051587
   Needham BL, 2010, AM J PUBLIC HEALTH, V100, P1040, DOI 10.2105/AJPH.2009.172809
   NEMEROFF CB, 1984, SCIENCE, V226, P1342, DOI 10.1126/science.6334362
   Nugent BM, 2015, FRONT NEUROENDOCRIN, V39, P28, DOI 10.1016/j.yfrne.2015.09.001
   Nyirenda MJ, 1998, J CLIN INVEST, V101, P2174, DOI 10.1172/JCI1567
   O'Regan D, 2004, AM J PHYSIOL-ENDOC M, V287, pE863, DOI 10.1152/ajpendo.00137.2004
   O'Regan D, 2008, J ENDOCRINOL, V196, P343, DOI 10.1677/JOE-07-0327
   O'Sullivan L, 2015, AM J PHYSIOL-RENAL, V308, pF1065, DOI 10.1152/ajprenal.00676.2014
   Österlund MK, 2000, NEUROSCIENCE, V95, P333
   Österlund MK, 2000, J CLIN ENDOCR METAB, V85, P3840, DOI 10.1210/jc.85.10.3840
   Östlund H, 2003, ANN NY ACAD SCI, V1007, P54, DOI 10.1196/annals.1286.006
   Payne JL, 2009, HARVARD REV PSYCHIAT, V17, P72, DOI 10.1080/10673220902899706
   Plotsky PM, 1998, PSYCHIAT CLIN N AM, V21, P293, DOI 10.1016/S0193-953X(05)70006-X
   Raison CL, 2003, AM J PSYCHIAT, V160, P1554, DOI 10.1176/appi.ajp.160.9.1554
   Rask E, 2001, J CLIN ENDOCR METAB, V86, P1418, DOI 10.1210/jc.86.3.1418
   Ravelli ACJ, 1998, LANCET, V351, P173, DOI 10.1016/S0140-6736(97)07244-9
   Richardson HN, 2006, ENDOCRINOLOGY, V147, P2506, DOI 10.1210/en.2005-1054
   Rivera M, 2012, MOL PSYCHIATR, V17, P604, DOI 10.1038/mp.2011.45
   Roberts RE, 2003, INT J OBESITY, V27, P514, DOI 10.1038/sj.ijo.0802204
   Roca CA, 2003, J CLIN ENDOCR METAB, V88, P3057, DOI 10.1210/jc.2002-021570
   Rogers JM, 2014, TOXICOL SCI, V137, P436, DOI 10.1093/toxsci/kft248
   Rubinow DR, 1996, AM J PSYCHIAT, V153, P974
   Saad MF, 1997, J CLIN ENDOCR METAB, V82, P579, DOI 10.1210/jc.82.2.579
   Salam RA, 2014, CURR OPIN CLIN NUTR, V17, P249, DOI 10.1097/MCO.0000000000000051
   Samuelsson AM, 2004, ENDOCRINOLOGY, V145, P4897, DOI 10.1210/en.2004-0742
   Sanchez SE, 2000, J REPROD IMMUNOL, V47, P49, DOI 10.1016/S0165-0378(99)00064-9
   Saper CB, 2002, NEURON, V36, P199, DOI 10.1016/S0896-6273(02)00969-8
   Schmaal L, 2017, MOL PSYCHIATR, V22, P900, DOI 10.1038/mp.2016.60
   Shaltout HA, 2012, HYPERTENSION, V59, P453, DOI 10.1161/HYPERTENSIONAHA.111.185876
   Sheline Y. I., 2002, European Psychiatry, V17, P300, DOI 10.1016/S0924-9338(02)00655-7
   Shin BC, 2012, J NEUROSCI RES, V90, P1169, DOI 10.1002/jnr.23013
   Shoener JA, 2006, AM J PHYSIOL-REG I, V290, pR1366, DOI 10.1152/ajpregu.00757.2004
   Smith JT, 2003, J ENDOCRINOL, V176, P313, DOI 10.1677/joe.0.1760313
   Soriano-Guillén L, 2016, CLIN CHEM LAB MED, V54, P1371, DOI 10.1515/cclm-2015-0555
   STEINER M, 1992, CLIN OBSTET GYNECOL, V35, P599, DOI 10.1097/00003081-199209000-00020
   TAKAHASHI LK, 1991, BRAIN RES, V558, P75, DOI 10.1016/0006-8993(91)90715-8
   Tang JI, 2011, J HYPERTENS, V29, P282, DOI 10.1097/HJH.0b013e328340aa18
   Tobe I, 2005, NEUROSCIENCE, V134, P387, DOI 10.1016/j.neuroscience.2005.04.023
   Tobet S, 2009, J NEUROENDOCRINOL, V21, P387, DOI 10.1111/j.1365-2826.2009.01834.x
   Tobet SA, 2013, PFLUG ARCH EUR J PHY, V465, P585, DOI 10.1007/s00424-013-1248-6
   vanOs J, 1997, ARCH GEN PSYCHIAT, V54, P625
   Vicennati V, 2002, J CLIN ENDOCR METAB, V87, P3984, DOI 10.1210/jc.87.8.3984
   Vicennati V, 2006, OBESITY, V14, P235, DOI 10.1038/oby.2006.30
   Videbech P, 2004, AM J PSYCHIAT, V161, P1957, DOI 10.1176/appi.ajp.161.11.1957
   Workman AD, 2013, J NEUROSCI, V33, P7368, DOI 10.1523/JNEUROSCI.5746-12.2013
   Yang L, 2015, JAMA INTERN MED, V175, P1412, DOI 10.1001/jamainternmed.2015.2405
   Young EA, 2000, ARCH GEN PSYCHIAT, V57, P1157, DOI 10.1001/archpsyc.57.12.1157
   Young EA, 2007, PSYCHONEUROENDOCRINO, V32, P843, DOI 10.1016/j.psyneuen.2007.05.013
   Yura S, 2005, CELL METAB, V1, P371, DOI 10.1016/j.cmet.2005.05.005
   Zhu WD, 2008, CLIN SCI, V114, P361, DOI 10.1042/CS20070347
NR 158
TC 55
Z9 57
U1 0
U2 14
PU INST CONFERENCE HIPPOCRATE
PI SURESNESS-CEDEX
PA 50 RUE CARNOT, SURESNESS-CEDEX, 92284, FRANCE
SN 1294-8322
EI 1958-5969
J9 DIALOGUES CLIN NEURO
JI Dialogues Clin. Neurosci.
PD DEC
PY 2016
VL 18
IS 4
BP 425
EP 436
PG 12
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA EJ7AQ
UT WOS:000393373600009
PM 28179814
DA 2025-06-11
ER

PT J
AU Chan, KL
   Cathomas, F
   Russo, SJ
AF Chan, Kenny L.
   Cathomas, Flurin
   Russo, Scott J.
TI Central and Peripheral Inflammation Link Metabolic Syndrome and Major
   Depressive Disorder
SO PHYSIOLOGY
LA English
DT Review
ID HIGH-FAT DIET; BLOOD-BRAIN-BARRIER; TUMOR-NECROSIS-FACTOR; MONOCYTE
   CHEMOATTRACTANT PROTEIN-1; GENE-ENVIRONMENT INTERACTION; ADIPOSE-TISSUE;
   BONE-MARROW; INSULIN-RESISTANCE; SKELETAL-MUSCLE; OBESE WOMEN
AB Metabolic syndrome and major depression are two of the most common and debilitating disorders worldwide, occurring with significant rates of comorbidity. Recent studies have uncovered that each of these conditions is associated with chronic, low-grade inflammation. This is characterized by increased circulating pro-inflammatory cytokines, altered leukocyte population frequencies in blood, accumulation of immune cells in tissues including the brain, and activation of these immune cells. Cytokines that become elevated during obesity can contribute to the progression of metabolic syndrome by directly causing insulin resistance. During chronic stress, there is evidence that these cytokines promote depression-like behavior by disrupting neurotransmitter synthesis and signal transduction. Animal models of obesity and depression have revealed a bi-directional relationship whereby high-fat feeding and chronic stress synergize and exacerbate metabolic dysregulation and behavioral abnormalities. Although far from conclusive, emerging evidence suggests that inflammation in the central and peripheral immune system may link metabolic syndrome to major depressive disorder. In this review, we will synthesize available data supporting this view and identify critical areas for future investigation.
C1 [Chan, Kenny L.; Cathomas, Flurin; Russo, Scott J.] Icahn Sch Med Mt Sinai, Dept Neurosci, Ctr Affect Neurosci, New York, NY 10029 USA.
   [Chan, Kenny L.; Cathomas, Flurin; Russo, Scott J.] Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at
   Mount Sinai
RP Russo, SJ (corresponding author), Icahn Sch Med Mt Sinai, Dept Neurosci, Ctr Affect Neurosci, New York, NY 10029 USA.
EM scott.russo@mssm.edu
RI Russo, Scott/R-7107-2019
OI Cathomas, Flurin/0000-0002-8274-1317
FU National Institute of Health [RO1 MH-090264, P50 MH-096890, P50
   AT-008661-01, RO1 MH-104559]; Early Postdoc Mobility Fellowship (Swiss
   National Science Foundation); Walter and Gertrud Siegenthaler
   Postdoctoral Fellowship
FX This review was supported by National Institute of Health Grants RO1
   MH-090264, P50 MH-096890 (to S.J.R.), P50 AT-008661-01 (to S.J.R.), RO1
   MH-104559 (to S.J.R.), an Early Postdoc Mobility Fellowship (Swiss
   National Science Foundation), and a Walter and Gertrud Siegenthaler
   Postdoctoral Fellowship (to F.C.).
CR Abildgaard A, 2011, PSYCHONEUROENDOCRINO, V36, P623, DOI 10.1016/j.psyneuen.2010.09.004
   Amano SU, 2014, CELL METAB, V19, P162, DOI 10.1016/j.cmet.2013.11.017
   Anacker C, 2011, PSYCHONEUROENDOCRINO, V36, P415, DOI 10.1016/j.psyneuen.2010.03.007
   [Anonymous], 2020, Campylobacter fact sheet
   [Anonymous], 2018, DEPR FACT SHEET
   Arakawa H, 2009, PHYSIOL BEHAV, V98, P139, DOI 10.1016/j.physbeh.2009.04.024
   Arnone D, 2018, NEUROSCI BIOBEHAV R, V92, P477, DOI 10.1016/j.neubiorev.2018.05.031
   Aslani S, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.178
   Athie-Morales V, 2004, J IMMUNOL, V172, P61, DOI 10.4049/jimmunol.172.1.61
   Aygun AD, 2005, MEDIAT INFLAMM, P180, DOI 10.1155/MI.2005.180
   Bastard JP, 2000, J CLIN ENDOCR METAB, V85, P3338, DOI 10.1210/jc.85.9.3338
   Baufeld C, 2016, ACTA NEUROPATHOL, V132, P361, DOI 10.1007/s00401-016-1595-4
   Beattie EC, 2002, SCIENCE, V295, P2282, DOI 10.1126/science.1067859
   Broussard SR, 2004, J IMMUNOL, V172, P7713, DOI 10.4049/jimmunol.172.12.7713
   Brydon L, 2005, BRAIN BEHAV IMMUN, V19, P540, DOI 10.1016/j.bbi.2004.12.003
   Bu L, 2013, AAPS J, V15, P1001, DOI 10.1208/s12248-013-9501-7
   Buckman LB, 2014, BRAIN BEHAV IMMUN, V35, P33, DOI 10.1016/j.bbi.2013.06.007
   Capuron L, 2011, PSYCHOL MED, V41, P1517, DOI 10.1017/S0033291710001984
   Capuron L, 2008, BIOL PSYCHIAT, V64, P896, DOI 10.1016/j.biopsych.2008.05.019
   Carey M, 2014, BRIT J GEN PRACT, V64, pE122, DOI 10.3399/bjgp14X677482
   Carter MJ, 2014, THER RECREAT J, V48, P275
   Chan KL, 2015, J BIOL CHEM, V290, P16979, DOI 10.1074/jbc.M115.646992
   Chandler S, 1997, J NEUROIMMUNOL, V72, P155, DOI 10.1016/S0165-5728(96)00179-8
   Chen AR, 2005, OBES RES, V13, P1311, DOI 10.1038/oby.2005.159
   Cho KW, 2016, J IMMUNOL, V197, P3650, DOI 10.4049/jimmunol.1600820
   Chuang JC, 2010, J LIPID RES, V51, P1344, DOI 10.1194/jlr.M002196
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   Delano MJ, 2011, J IMMUNOL, V187, P911, DOI 10.4049/jimmunol.1100588
   Delgado I, 2018, PSYCHONEUROENDOCRINO, V91, P55, DOI 10.1016/j.psyneuen.2018.02.030
   Demir S, 2015, NEUROPSYCH DIS TREAT, V11, P2253, DOI 10.2147/NDT.S89470
   Deshmane SL, 2009, J INTERF CYTOK RES, V29, P313, DOI 10.1089/jir.2008.0027
   Devêvre EF, 2015, J IMMUNOL, V194, P3917, DOI 10.4049/jimmunol.1402655
   Dinel AL, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024325
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   Dutheil S, 2016, NEUROPSYCHOPHARMACOL, V41, P1874, DOI 10.1038/npp.2015.357
   Engler H, 2004, J NEUROIMMUNOL, V148, P106, DOI 10.1016/j.jneuroim.2003.11.011
   Felger JC, 2012, FRONT NEUROENDOCRIN, V33, P315, DOI 10.1016/j.yfrne.2012.09.003
   Feng B, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024358
   Fink LN, 2013, DIABETOLOGIA, V56, P1623, DOI 10.1007/s00125-013-2897-x
   Fink LN, 2014, OBESITY, V22, P747, DOI 10.1002/oby.20615
   Frenois F, 2007, PSYCHONEUROENDOCRINO, V32, P516, DOI 10.1016/j.psyneuen.2007.03.005
   Geissmann F, 2003, IMMUNITY, V19, P71, DOI 10.1016/S1074-7613(03)00174-2
   Glassman Alexander H, 2007, Dialogues Clin Neurosci, V9, P9
   Goyal R, 2012, N AM J MED SCI, V4, P180, DOI 10.4103/1947-2714.94944
   Grigoleit JS, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0028330
   Gustafson DR, 2007, J INTERN MED, V262, P643, DOI 10.1111/j.1365-2796.2007.01869.x
   Hassan AM, 2019, NUTR NEUROSCI, V22, P877, DOI 10.1080/1028415X.2018.1465713
   Heidt T, 2014, NAT MED, V20, P754, DOI 10.1038/nm.3589
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Heufler C, 1996, EUR J IMMUNOL, V26, P659, DOI 10.1002/eji.1830260323
   Hodes GE, 2014, P NATL ACAD SCI USA, V111, P16136, DOI 10.1073/pnas.1415191111
   Hotamisligil GS, 1996, SCIENCE, V271, P665, DOI 10.1126/science.271.5249.665
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   HOTAMISLIGIL GS, 1994, P NATL ACAD SCI USA, V91, P4854, DOI 10.1073/pnas.91.11.4854
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Isingrini E, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010404
   Jung C, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/958403
   Kanoski SE, 2010, J ALZHEIMERS DIS, V21, P207, DOI 10.3233/JAD-2010-091414
   Kessler RC, 2005, ARCH GEN PSYCHIAT, V62, P593, DOI 10.1001/archpsyc.62.6.593
   Kim HJ, 2004, DIABETES, V53, P1060, DOI 10.2337/diabetes.53.4.1060
   Kim KS, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030066
   Konsman JP, 2002, TRENDS NEUROSCI, V25, P154, DOI 10.1016/S0166-2236(00)02088-9
   Krinninger P, 2014, J CLIN ENDOCR METAB, V99, P2500, DOI 10.1210/jc.2013-2611
   Ladwig KH, 2003, BRAIN BEHAV IMMUN, V17, P268, DOI 10.1016/S0889-1591(03)00056-4
   Lamers F, 2018, PSYCHOL MED, V48, P1102, DOI 10.1017/S0033291717002483
   Lauridsen JK, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/tp.2016.259
   Lehmann ML, 2016, J NEUROINFLAMM, V13, DOI 10.1186/s12974-016-0672-x
   Lewitus GM, 2016, NEURON, V90, P483, DOI 10.1016/j.neuron.2016.03.030
   Li PP, 2010, J BIOL CHEM, V285, P15333, DOI 10.1074/jbc.M110.100263
   Liu J, 2009, NAT MED, V15, P940, DOI 10.1038/nm.1994
   Lumeng CN, 2007, J CLIN INVEST, V117, P175, DOI 10.1172/JCI29881
   Lutter M, 2008, NAT NEUROSCI, V11, P752, DOI 10.1038/nn.2139
   Lutter M, 2008, J NEUROSCI, V28, P3071, DOI 10.1523/JNEUROSCI.5584-07.2008
   Maes M, 1997, CYTOKINE, V9, P853, DOI 10.1006/cyto.1997.0238
   Maes M, 2011, PROG NEURO-PSYCHOPH, V35, P702, DOI 10.1016/j.pnpbp.2010.12.017
   MAES M, 1992, J PSYCHIAT RES, V26, P125, DOI 10.1016/0022-3956(92)90004-8
   Mandelli L, 2013, NEUROSCI BIOBEHAV R, V37, P2375, DOI 10.1016/j.neubiorev.2013.07.011
   Martinez Fernando O, 2014, F1000Prime Rep, V6, P13, DOI 10.12703/P6-13
   McKim DB, 2018, MOL PSYCHIATR, V23, P1421, DOI 10.1038/mp.2017.64
   McLaughlin T, 2014, ARTERIOSCL THROM VAS, V34, P2637, DOI 10.1161/ATVBAHA.114.304636
   Ménard C, 2016, NEUROSCIENCE, V321, P138, DOI 10.1016/j.neuroscience.2015.05.053
   Menard C, 2017, NAT NEUROSCI, V20, P1752, DOI 10.1038/s41593-017-0010-3
   Milaneschi Y, 2017, JAMA PSYCHIAT, V74, P1214, DOI 10.1001/jamapsychiatry.2017.3016
   Milanski M, 2009, J NEUROSCI, V29, P359, DOI 10.1523/JNEUROSCI.2760-08.2009
   Milanski M, 2012, DIABETES, V61, P1455, DOI 10.2337/db11-0390
   Mildner A, 2007, NAT NEUROSCI, V10, P1544, DOI 10.1038/nn2015
   Miller AH, 2016, NAT REV IMMUNOL, V16, P22, DOI 10.1038/nri.2015.5
   Miller GE, 2002, AM J CARDIOL, V90, P1279, DOI 10.1016/S0002-9149(02)02863-1
   Morinaga H, 2015, DIABETES, V64, P1120, DOI 10.2337/db14-1238
   NANJI AA, 1985, AM J CLIN PATHOL, V84, P346, DOI 10.1093/ajcp/84.3.346
   NIKLASSON F, 1984, BIOL PSYCHIAT, V19, P1183
   Niraula A, 2018, J NEUROSCI, V38, P2328, DOI 10.1523/JNEUROSCI.2568-17.2018
   Nunemaker CS, 2014, J ENDOCRINOL, V222, P267, DOI 10.1530/JOE-14-0126
   Pandey GN, 2012, J PSYCHIATR RES, V46, P57, DOI 10.1016/j.jpsychires.2011.08.006
   Patsouris D, 2008, CELL METAB, V8, P301, DOI 10.1016/j.cmet.2008.08.015
   Pillon NJ, 2015, AM J PHYSIOL-ENDOC M, V309, pE35, DOI 10.1152/ajpendo.00611.2014
   Pillon NJ, 2014, DIABETES, V63, P3815, DOI 10.2337/db14-0150
   Poitou C, 2011, ARTERIOSCL THROM VAS, V31, P2322, DOI 10.1161/ATVBAHA.111.230979
   Qi L, 2008, NUTR REV, V66, P684, DOI 10.1111/j.1753-4887.2008.00128.x
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Räikkönen K, 2007, DIABETES CARE, V30, P872, DOI 10.2337/dc06-1857
   Raison CL, 2013, JAMA PSYCHIAT, V70, P31, DOI 10.1001/2013.jamapsychiatry.4
   RENAULT PF, 1987, ARCH INTERN MED, V147, P1577, DOI 10.1001/archinte.147.9.1577
   Rickards H, 2005, J NEUROL NEUROSUR PS, V76, pI48, DOI 10.1136/jnnp.2004.060426
   Rui LY, 2001, J CLIN INVEST, V107, P181, DOI 10.1172/JCI10934
   Ryder E, 2014, DIABETES METAB SYND, V8, P197, DOI 10.1016/j.dsx.2014.09.002
   SAPOLSKY R, 1987, SCIENCE, V238, P522, DOI 10.1126/science.2821621
   Schiepers OJG, 2005, PROG NEURO-PSYCHOPH, V29, P201, DOI 10.1016/j.pnpbp.2004.11.003
   Schmidt FM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0121971
   Schwartz MW, 2000, NATURE, V404, P661, DOI 10.1038/35007534
   Setiawan E, 2015, JAMA PSYCHIAT, V72, P268, DOI 10.1001/jamapsychiatry.2014.2427
   Shi C, 2011, NAT REV IMMUNOL, V11, P762, DOI 10.1038/nri3070
   Shi H, 2006, J CLIN INVEST, V116, P3015, DOI 10.1172/JCI28898
   Simon NM, 2008, EUR NEUROPSYCHOPHARM, V18, P230, DOI 10.1016/j.euroneuro.2007.06.004
   Singer K, 2015, J BIOL CHEM, V290, P13250, DOI 10.1074/jbc.M114.634568
   Singer K, 2014, MOL METAB, V3, P664, DOI 10.1016/j.molmet.2014.06.005
   Spranger J, 2006, DIABETES, V55, P141, DOI 10.2337/diabetes.55.1.141
   Stellwagen D, 2006, NATURE, V440, P1054, DOI 10.1038/nature04671
   Stewart AM, 2015, BEHAV BRAIN RES, V276, P84, DOI 10.1016/j.bbr.2014.08.037
   Stranahan AM, 2016, J CEREBR BLOOD F MET, V36, P2108, DOI 10.1177/0271678X16642233
   Tagliari B, 2011, NEUROCHEM RES, V36, P487, DOI 10.1007/s11064-010-0367-0
   Takahashi K, 2008, AM J PHYSIOL-ENDOC M, V294, pE898, DOI 10.1152/ajpendo.00131.2007
   Takase K, 2016, OBESITY, V24, P886, DOI 10.1002/oby.21441
   Talukdar S, 2012, NAT MED, V18, P1407, DOI 10.1038/nm.2885
   Thaipisuttikul P, 2014, NEUROPSYCH DIS TREAT, V10, P2097, DOI 10.2147/NDT.S72026
   Trottier MD, 2012, P NATL ACAD SCI USA, V109, P7622, DOI 10.1073/pnas.1205129109
   Valdearcos M, 2017, CELL METAB, V26, P185, DOI 10.1016/j.cmet.2017.05.015
   Vezzani A, 2011, BRAIN BEHAV IMMUN, V25, P1281, DOI 10.1016/j.bbi.2011.03.018
   Wang YL, 2018, J NEUROINFLAMM, V15, DOI 10.1186/s12974-018-1054-3
   Weisberg SP, 2006, J CLIN INVEST, V116, P115, DOI 10.1172/JCI24335
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Wensveen FM, 2015, NAT IMMUNOL, V16, P376, DOI 10.1038/ni.3120
   Winer DA, 2011, NAT MED, V17, P610, DOI 10.1038/nm.2353
   Wium-Andersen MK, 2013, JAMA PSYCHIAT, V70, P176, DOI 10.1001/2013.jamapsychiatry.102
   Wohleb ES, 2013, J NEUROSCI, V33, P13820, DOI 10.1523/JNEUROSCI.1671-13.2013
   Wohleb ES, 2011, J NEUROSCI, V31, P6277, DOI 10.1523/JNEUROSCI.0450-11.2011
   Wu D, 2011, SCIENCE, V332, P243, DOI 10.1126/science.1201475
   Wu HZ, 2007, CIRCULATION, V115, P1029, DOI 10.1161/CIRCULATIONAHA.106.638379
   Wu HL, 2018, METAB BRAIN DIS, V33, P177, DOI 10.1007/s11011-017-0140-z
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yirmiya R, 1996, BRAIN RES, V711, P163, DOI 10.1016/0006-8993(95)01415-2
   Yoshimura A, 2015, OBESITY FACTS, V8, P1, DOI 10.1159/000373881
   Zamarron BF, 2017, DIABETES, V66, P392, DOI 10.2337/db16-0500
   Zunszain PA, 2011, PROG NEURO-PSYCHOPH, V35, P722, DOI 10.1016/j.pnpbp.2010.04.011
NR 145
TC 163
Z9 170
U1 1
U2 46
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 1548-9213
EI 1548-9221
J9 PHYSIOLOGY
JI Physiology
PD MAR
PY 2019
VL 34
IS 2
BP 123
EP 133
DI 10.1152/physiol.00047.2018
PG 11
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Physiology
GA HK4EN
UT WOS:000457874300006
PM 30724127
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Knapen, J
   Vancampfort, D
   Moriën, Y
   Marchal, Y
AF Knapen, Jan
   Vancampfort, Davy
   Morien, Yves
   Marchal, Yannick
TI Exercise therapy improves both mental and physical health in patients
   with major depression
SO DISABILITY AND REHABILITATION
LA English
DT Article
DE Depressive disorder; metabolic syndrome; physical therapy
ID CORONARY-HEART-DISEASE; TRANSTHEORETICAL MODEL; ANXIETY; METAANALYSIS;
   DISORDERS; MORTALITY; FITNESS; OBESITY; RISK
AB Purpose: to present clinical guidelines for exercise therapy in depressed patients derived from recent meta-analyses. Method: four meta-analyses on effects of physical exercise on mental and physical in depression were analysed. Results: For mild to moderate depression the effect of exercise may be comparable to antidepressant medication and psychotherapy; for severe depression exercise seems to be a valuable complementary therapy to the traditional treatments. Depression is associated with a high incidence of co-morbid somatic illnesses, especially cardiovascular diseases, type 2 diabetes and metabolic syndrome. Exercise is extremely powerful in preventing and treating these diseases. Physical exercise is an outstanding opportunity for the treatment of patients who have a mix of mental and physical health problems. Exercise therapy also improves body image, patient s coping strategies with stress, quality of life and independence in activities of daily living in older adults. Conclusions: Physical therapists should be aware, that several characteristics of major depression (e.g. loss of interest, motivation and energy, generalised fatigue, a low self-worth and self-confidence, fear to move, and psychosomatic complaints) and physical health problems interfere with participation in exercise. Therefore, motivational strategies should be incorporated in exercise interventions to enhance the patients' motivation and adherence in exercise programs.
C1 [Knapen, Jan; Vancampfort, Davy] Katholieke Univ Leuven, Dept Rehabil Sci, Leuven, Belgium.
   [Knapen, Jan; Marchal, Yannick] Huis Chron Zorg, St Truiden, Belgium.
   [Knapen, Jan; Morien, Yves] AZERTIE, B-3520 Zonhoven, Belgium.
   [Vancampfort, Davy] Univ Psychiat Ctr KU Leuven, Dept Psychomotor Therapy, Kortenberg, Belgium.
   [Marchal, Yannick] Vrije Univ Brussel, Dept Family Med & Chron Care, Brussels, Belgium.
C3 KU Leuven; KU Leuven; Vrije Universiteit Brussel
RP Knapen, J (corresponding author), AZERTIE, Boddenveldweg 11, B-3520 Zonhoven, Belgium.
EM jan.knapen@faber.kuleuven.be
RI Vancampfort, Davy/AAD-1987-2019
CR [Anonymous], 1998, BORGS PERCEIVED EXER
   [Anonymous], GLOB BURD DIS 2004 U
   [Anonymous], 2010, ACSMS GUIDELINES EXE
   [Anonymous], 2010, MMWR, V59, P1229
   [Anonymous], 2010, DEPR TREATM MAN DEPR
   [Anonymous], 2009, Motivational interviewing: Preparing people for change
   Carter MJ, 2014, THER RECREAT J, V48, P275
   Cooney GM, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004366.pub6
   Demyttenaere K, 2004, JAMA-J AM MED ASSOC, V291, P2581, DOI 10.1001/jama.291.21.2581
   Druss BG, 2009, MOL PSYCHIATR, V14, P728, DOI 10.1038/mp.2008.13
   García-Toro M, 2012, J AFFECT DISORDERS, V140, P200, DOI 10.1016/j.jad.2012.03.031
   Guh DP, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-88
   Knapen J, 2005, PSYCHOTHER PSYCHOSOM, V74, P353, DOI 10.1159/000087782
   Knapen J, 2003, J SPORT MED PHYS FIT, V43, P513
   Knapen J, 2003, DISABIL REHABIL, V25, P1312, DOI 10.1080/09638280310001616277
   Lepine Jean-Pierre, 2011, Neuropsychiatr Dis Treat, V7, P3, DOI 10.2147/NDT.S19617
   Lett HS, 2004, PSYCHOSOM MED, V66, P305, DOI 10.1097/01.psy.0000126207.43307.c0
   Lopresti AL, 2013, J AFFECT DISORDERS, V148, P12, DOI 10.1016/j.jad.2013.01.014
   Marshall SJ, 2001, ANN BEHAV MED, V23, P229, DOI 10.1207/S15324796ABM2304_2
   Ösby U, 2001, ARCH GEN PSYCHIAT, V58, P844, DOI 10.1001/archpsyc.58.9.844
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Penninx BWJH, 2001, ARCH GEN PSYCHIAT, V58, P221, DOI 10.1001/archpsyc.58.3.221
   Preiss K, 2013, OBES REV, V14, P906, DOI 10.1111/obr.12052
   Prochaska JO, 1997, AM J HEALTH PROMOT, V12, P38, DOI 10.4278/0890-1171-12.1.38
   Rugulies R, 2002, AM J PREV MED, V23, P51, DOI 10.1016/S0749-3797(02)00439-7
   Salmon P, 2001, CLIN PSYCHOL REV, V21, P33, DOI 10.1016/S0272-7358(99)00032-X
   Silveira H, 2013, NEUROPSYCHOBIOLOGY, V67, P61, DOI [10.1159/000345160, 10.1159/0]
   Ströhle A, 2009, J PSYCHIATR RES, V43, P1013, DOI 10.1016/j.jpsychires.2009.02.004
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vancampfort D, 2011, PSYCHIAT RES, V187, P62, DOI 10.1016/j.psychres.2010.11.027
   Whang W, 2009, J AM COLL CARDIOL, V53, P950, DOI 10.1016/j.jacc.2008.10.060
   Zoeller RF, 2007, AM J LIFESTYLE MED, V1, P175, DOI 10.1177/1559827607300518
NR 32
TC 246
Z9 282
U1 9
U2 318
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-8288
EI 1464-5165
J9 DISABIL REHABIL
JI Disabil. Rehabil.
PY 2015
VL 37
IS 16-17
BP 1490
EP 1495
DI 10.3109/09638288.2014.972579
PG 6
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Rehabilitation
GA CN7RC
UT WOS:000358630700013
PM 25342564
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Ramírez-Garza, SL
   Laveriano-Santos, EP
   Moreno, JJ
   Bodega, P
   de Cos-Gandoy, A
   de Miguel, M
   Santos-Beneit, G
   Fernández-Alvira, JM
   Fernández-Jiménez, R
   Martínez-Gómez, J
   Ruiz-León, AM
   Estruch, R
   Lamuela-Raventós, RM
   Tresserra-Rimbau, A
AF Ramirez-Garza, Sonia L.
   Laveriano-Santos, Emily P.
   Moreno, Juan J.
   Bodega, Patricia
   de Cos-Gandoy, Amaya
   de Miguel, Mercedes
   Santos-Beneit, Gloria
   Fernandez-Alvira, Juan Miguel
   Fernandez-Jimenez, Rodrigo
   Martinez-Gomez, Jesus
   Ruiz-Leon, Ana Maria
   Estruch, Ramon
   Lamuela-Raventos, Rosa M.
   Tresserra-Rimbau, Anna
TI Metabolic syndrome, adiposity, diet, and emotional eating are associated
   with oxidative stress in adolescents
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE nutritional status; nutrition assessment; fish; refined cereals;
   obesity; emotion; anxiety; depression
ID CARDIOVASCULAR RISK-FACTORS; BODY-MASS INDEX; CENTRAL-NERVOUS-SYSTEM;
   INSULIN-RESISTANCE; SPANISH VERSION; MENTAL-HEALTH; CHILDREN;
   DEPRESSION; 8-ISOPROSTANE; ACTIVATION
AB Background Metabolic syndrome (MS), a condition related to adiposity and oxidative stress, can develop in adolescence, a critical stage in life that impacts health in adulthood. However, there is scarce scientific research about the relationship between lifestyle factors, emotion management, and oxidative stress in this phase of life.
   Aim To analyze whether nutritional parameters, lifestyle factors, emotion management, and MS in adolescents are associated with oxidative stress measured by the biomarker 8-isoprostane.
   Methods A cross-sectional study was carried out in 132 adolescents (48.5% girls, aged 120.48years) and data were collected on nutritional parameters (anthropometric measurements, biochemical analyzes, and blood pressure), lifestyle factors (physical activity, sleep, and diet), and emotion management (self-esteem, emotional eating, and mood). 8-isoprostane was analyzed in spot urine samples. The study population was categorized in three groups (healthy, at-risk, and with MS) using the International Diabetes Federation definition of MS in adolescents. To capture more complex interactions, a multiple linear regression was used to analyze the association between 8-isoprostane and the aforementioned variables.
   Results Urinary 8-isoprostane levels were significantly higher in the MS group compared to the healthy group (1,280 +/- 543pg./mg vs. 950 +/- 416pg./mg respectively). In addition, univariable analysis revealed positive significant associations between 8-isoprostane and body mass index, waist circumference, waist-to-height ratio, body fat percentage, blood lipid profile and glucose, emotional eating, and refined cereal intake. Conversely, a negative significant association was found between 8-isoprostane and sleep duration and fish intake. The multiple linear regression analysis revealed associations between 8-isoprostane and LDL-c (beta=0.173 value of p=0.049), emotional eating (low beta=0.443, value of p=0.036; high beta=0.152, value of p=0.470), refined cereal intake (beta =0.191, value of p=0.024), and fish intake (beta=-0.187, value of p=0.050).
   Conclusion The MS group, LDL-c, emotional eating, and high refined cereals and low fish intakes were associated with higher levels of oxidative stress in an adolescent population.
C1 [Ramirez-Garza, Sonia L.; Laveriano-Santos, Emily P.; Moreno, Juan J.; Lamuela-Raventos, Rosa M.; Tresserra-Rimbau, Anna] Univ Barcelona, Inst Nutr & Food Safety Res, Sch Pharm & Food Sci, Dept Nutr Food Sci & Gastron,XIA, Barcelona, Spain.
   [Laveriano-Santos, Emily P.; Moreno, Juan J.; Ruiz-Leon, Ana Maria; Estruch, Ramon; Lamuela-Raventos, Rosa M.; Tresserra-Rimbau, Anna] Inst Salud Carlos III, Consorcio CIBER, MP Fisiopatol Obesidad Nutr, Madrid, Spain.
   [Bodega, Patricia; de Cos-Gandoy, Amaya; de Miguel, Mercedes; Santos-Beneit, Gloria] Fdn Sci Hlth & Educ, Barcelona, Spain.
   [Bodega, Patricia; de Cos-Gandoy, Amaya; de Miguel, Mercedes; Fernandez-Alvira, Juan Miguel; Fernandez-Jimenez, Rodrigo; Martinez-Gomez, Jesus] Ctr Nacl Invest Cardiovasc, Madrid, Spain.
   [Santos-Beneit, Gloria] Icahn Sch Med Mt Sinai, Zena & Michael Wiener Cardiovasc Inst, New York, NY USA.
   [Fernandez-Jimenez, Rodrigo] Hosp Univ Clin San Carlos, Madrid, Spain.
   [Fernandez-Alvira, Juan Miguel] Ctr Invest Biomed Red Enfermedades Cardiovasc, Madrid, Spain.
   [Estruch, Ramon] Univ Barcelona, Inst Invest Biomed August Pi &Sunyer, Hosp Clin, Dept Internal Med, Barcelona, Spain.
C3 University of Barcelona; Instituto de Salud Carlos III; Centro Nacional
   de Investigaciones Cardiovasculares (CNIC); Icahn School of Medicine at
   Mount Sinai; CIBER - Centro de Investigacion Biomedica en Red; CIBERCV;
   University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS
RP Tresserra-Rimbau, A (corresponding author), Univ Barcelona, Inst Nutr & Food Safety Res, Sch Pharm & Food Sci, Dept Nutr Food Sci & Gastron,XIA, Barcelona, Spain.; Tresserra-Rimbau, A (corresponding author), Inst Salud Carlos III, Consorcio CIBER, MP Fisiopatol Obesidad Nutr, Madrid, Spain.
EM annatresserra@ub.edu
RI Raventos, Rosa/F-3986-2016; Martínez Gómez, Jesús/HKF-7276-2023; de Cos,
   Amaya/KEJ-5787-2024; Tresserra-Rimbau, Anna/ABD-1099-2020; Fernandez,
   Rodrigo/AFV-4674-2022; Estruch, Ramon/AAZ-3723-2020; Fernández-Alvira,
   Juan/O-9665-2019; Ruiz-Leon, Ana Maria/HTS-8184-2023; Moreno,
   Juan/AAA-1312-2019; Santos-Beneit, Gloria/E-4652-2019; LAVERIANO SANTOS,
   EMILY/AFX-6417-2022
OI RAMIREZ-GARZA, SONIA L./0000-0001-6337-100X; de Cos-Gandoy,
   Amaya/0000-0003-4799-0147; Santos-Beneit, Gloria/0000-0002-3979-7067;
   LAVERIANO SANTOS, EMILY/0000-0002-4852-6074; Martinez Gomez,
   Jesus/0000-0002-7770-073X
FU SHE Foundation; la Caixa Foundation [100010434, LCF/PR/CE16/10700001,
   LCF/PR/MS19/12220001]; Fundacio la Marato de TV3 [369/C/2016];
   Ministerio de Ciencia, Innovacion y Universidades
   [PID2020-114022RB-I00]; CIBEROBN from the Instituto de Salud Carlos III
   (ISCIII) from the Ministerio de Ciencia, Innovacion y Universidades
   (AEI/FEDER, UE); Generalitat de Catalunya; ISCIII; Ministerio de Ciencia
   e Innovacion (MCIN); Pro CNIC Foundation; MICIN/AEI [CEX2020-001041-S];
   MICIN/AEI/FEDER, UE [CEX2021-001234-M]; ISCIII [PI22/01560]; European
   Union; Generalitat de Catalunya [EMC/503/2021]; Ministerio de Educacion,
   Cultura y Deporte [FPU21/04891]
FX The authors especially thank all the volunteers and their families,
   teachers, and schools for their contribution to the SI! Program for
   Secondary Schools. The authors thank the SHE Foundation (intellectual
   owner of the SI! Program) and its partners Isabel Carvajal, Domenec
   Haro, Xavier Orrit, Carla Rodriguez, Vanessa Carral, Rosa Casas,
   Carolina E. Storniolo, for their contribution to the study design,
   coordination, development, and all personnel who performed measurements
   in adolescents at participating schools. The SI! Program for Secondary
   Schools trial was supported by the SHE Foundation, the la Caixa
   Foundation (LCF/PR/CE16/10700001), the Fundacio la Marato de TV3 (grant
   number 369/C/2016). Support was also provided by the Ministerio de
   Ciencia, Innovacion y Universidades (PID2020-114022RB-I00), CIBEROBN
   from the Instituto de Salud Carlos III (ISCIII) from the Ministerio de
   Ciencia, Innovacion y Universidades (AEI/FEDER, UE), and Generalitat de
   Catalunya. The CNIC is supported by the ISCIII, the Ministerio de
   Ciencia e Innovacion (MCIN) and the Pro CNIC Foundation, and is a Severo
   Ochoa Center of Excellence (grant CEX2020-001041-S funded by
   MICIN/AEI/10.13039/501100011033), and INSA-UB a Maria de Maeztu Center
   of Excellence (grant CEX2021-001234-M funded by MICIN/AEI/FEDER, UE).
   RF-J is recipient of grant PI22/01560 funded by the ISCIII and co-funded
   by the European Union. GS-B was the recipient of grant
   LCF/PR/MS19/12220001 funded by la Caixa Foundation (ID 100010434). AT-R
   is a Serra Hunter fellow. EL-S was a FI-SDUR (EMC/503/2021) fellowship
   from the Generalitat de Catalunya. JM-G is a recipient of grant
   FPU21/04891 (Ayudas para la formacion de profesorado universitario,
   FPU-2021) from the Ministerio de Educacion, Cultura y Deporte.
CR Ahonen EQ, 2007, GAC SANIT, V21, P43, DOI 10.1157/13099120
   Andersson A, 2007, J NUTR, V137, P1401, DOI 10.1093/jn/137.6.1401
   [Anonymous], 2013, Grup collaborador enquesta FRESC 2012. Informe FRESC 2012: 25 anys d'enquestes a adolescents escolaritzats de Barcelona
   Araki S, 2010, EUR J PEDIATR, V169, P965, DOI 10.1007/s00431-010-1157-z
   Bhatt S, 2020, DRUG DISCOV TODAY, V25, P1270, DOI 10.1016/j.drudis.2020.05.001
   Bloedon LT, 2008, J AM COLL NUTR, V27, P65, DOI 10.1080/07315724.2008.10719676
   Chandler JL, 2016, PEDIATR OBES, V11, P120, DOI 10.1111/ijpo.12033
   Cole TJ, 2012, PEDIATR OBES, V7, P284, DOI 10.1111/j.2047-6310.2012.00064.x
   Conway MC, 2021, EUR J NUTR, V60, P1415, DOI 10.1007/s00394-020-02326-w
   Costabile G, 2022, NUTR METAB CARDIOVAS, V32, P715, DOI 10.1016/j.numecd.2021.12.016
   Costabile G, 2015, METAB SYNDR RELAT D, V13, P187, DOI 10.1089/met.2014.0119
   Czerska M, 2016, INT J OCCUP MED ENV, V29, P179, DOI 10.13075/ijomeh.1896.00596
   Dennis BA, 2013, CHILD OBES, V9, P15, DOI 10.1089/chi.2011.0092
   Deshpande G, 2014, J PEDIATR GASTR NUTR, V58, P177, DOI 10.1097/MPG.0000000000000174
   Diniz BS, 2018, J PSYCHIATR RES, V102, P29, DOI 10.1016/j.jpsychires.2018.02.023
   Du C, 2022, NUTRIENTS, V14, DOI 10.3390/nu14051045
   Enright L, 2010, NUTR J, V9, DOI 10.1186/1475-2891-9-12
   Ercan H, 2016, METAB SYNDR RELAT D, V14, P318, DOI 10.1089/met.2016.0011
   Erkkilä AT, 2019, LIPIDS, V54, P453, DOI 10.1002/lipd.12176
   Farran A., 2003, TABLAS COMPOSICION A
   Fedoce AD, 2018, FREE RADICAL RES, V52, P737, DOI 10.1080/10715762.2018.1475733
   Fernández-Ballarth JD, 2010, BRIT J NUTR, V103, P1808, DOI 10.1017/S0007114509993837
   Fernandez-Jimenez R, 2019, AM HEART J, V215, P27, DOI 10.1016/j.ahj.2019.03.014
   Flynn JT., 2018, JAMA Pediatr, V172, P1087, DOI [10.1001/jamapediatrics.2018.2882, DOI 10.1001/JAMAPEDIATRICS.2018.2882]
   Giacco R, 2014, NUTR METAB CARDIOVAS, V24, P837, DOI 10.1016/j.numecd.2014.01.007
   Guillot N, 2009, FASEB J, V23, P2909, DOI 10.1096/fj.09-133421
   Hansson P, 2015, NUTRITION, V31, P847, DOI 10.1016/j.nut.2014.12.015
   He K, 2004, STROKE, V35, P1538, DOI 10.1161/01.STR.0000130856.31468.47
   Hua JN, 2021, FRONT NEUROL, V12, DOI 10.3389/fneur.2021.635564
   Jáuregui-Lobera I, 2014, NUTRIENTS, V6, P5619, DOI 10.3390/nu6125619
   Jones J, 2019, EAT BEHAV, V33, P97, DOI 10.1016/j.eatbeh.2019.05.003
   Juton C, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051629
   Kang NR, 2020, PEDIATR GASTROENTERO, V23, P15
   Karamouzis I, 2011, HORM METAB RES, V43, P607, DOI 10.1055/s-0031-1284355
   Kelly Aaron S, 2006, J Cardiometab Syndr, V1, P248, DOI 10.1111/j.1559-4564.2006.05758.x
   Kerley CP, 2019, NUTR RES REV, V32, P1, DOI 10.1017/S0954422418000148
   Khalid S, 2016, BRIT J NUTR, V116, P2097, DOI 10.1017/S0007114516004359
   Kornacka M, 2021, EAT WEIGHT DISORD-ST, V26, P273, DOI 10.1007/s40519-020-00857-z
   Leonard B, 2012, NEUROSCI BIOBEHAV R, V36, P764, DOI 10.1016/j.neubiorev.2011.12.005
   Liu T, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0138904
   Lopez-Cepero A, 2018, J ACAD NUTR DIET, V118, P849, DOI 10.1016/j.jand.2017.06.007
   Lopresti AL, 2014, PROG NEURO-PSYCHOPH, V48, P102, DOI 10.1016/j.pnpbp.2013.09.017
   Marshall S, 2020, J ACAD NUTR DIET, V120, P1859, DOI 10.1016/j.jand.2020.06.021
   Martínez-González MA, 2020, AM J CLIN NUTR, V111, P291, DOI 10.1093/ajcn/nqz298
   Martins BG, 2021, EAT WEIGHT DISORD-ST, V26, P525, DOI 10.1007/s40519-020-00885-9
   Medina-Remón A, 2009, ANAL CHIM ACTA, V634, P54, DOI 10.1016/j.aca.2008.12.012
   Milne GL, 2015, BBA-MOL CELL BIOL L, V1851, P433, DOI 10.1016/j.bbalip.2014.10.007
   Moreiras O., 2018, Guia de Practicas, V19th
   Mori TA, 1999, METABOLISM, V48, P1402, DOI 10.1016/S0026-0495(99)90150-6
   Nagata C, 2017, CHRONOBIOL INT, V34, P1187, DOI 10.1080/07420528.2017.1355313
   Noubiap JJ, 2022, LANCET CHILD ADOLESC, V6, P158, DOI 10.1016/S2352-4642(21)00374-6
   O'Neil A, 2014, AM J PUBLIC HEALTH, V104, pE31, DOI 10.2105/AJPH.2014.302110
   Ohrt TK, 2020, OBES SCI PRACT, V6, P524, DOI 10.1002/osp4.439
   Ostrow V, 2011, J PEDIATR-US, V158, P628, DOI 10.1016/j.jpeds.2010.09.081
   Pacheco LS, 2021, APPETITE, V156, DOI 10.1016/j.appet.2020.104857
   Pipingas A, 2015, J FUNCT FOODS, V19, P949, DOI 10.1016/j.jff.2014.10.028
   Polidori N, 2020, J PEDIATR ENDOCR MET, V33, P1183, DOI 10.1515/jpem-2020-0138
   Purcell R, 2014, AM J CLIN NUTR, V100, P1019, DOI 10.3945/ajcn.114.091223
   Rajmil L, 2003, MED CARE, V41, P1153, DOI 10.1097/01.MLR.0000088460.42155.65
   Raut SK, 2023, MOL CELL BIOCHEM, V478, P185, DOI 10.1007/s11010-022-04496-z
   Ripoli C, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-26271-2
   Robson MJ, 2017, ACS CHEM NEUROSCI, V8, P932, DOI 10.1021/acschemneuro.6b00412
   Rosner B, 2008, AM J EPIDEMIOL, V167, P653, DOI 10.1093/aje/kwm348
   SADEH A, 1994, SLEEP, V17, P201, DOI 10.1093/sleep/17.3.201
   Salim S, 2017, J PHARMACOL EXP THER, V360, P201, DOI 10.1124/jpet.116.237503
   Salim S, 2014, CURR NEUROPHARMACOL, V12, P140, DOI 10.2174/1570159X11666131120230309
   Savage K, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11050822
   Savage K, 2021, EXP AGING RES, V47, P322, DOI 10.1080/0361073X.2021.1883966
   Sawyer SM, 2012, LANCET, V379, P1630, DOI 10.1016/S0140-6736(12)60072-5
   Selvaraju V, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/9604740
   Shaito A, 2022, FRONT BIOSCI-LANDMRK, V27, DOI 10.31083/j.fbl2703105
   Sharma AK, 2015, PEDIATR RES, V78, P723, DOI 10.1038/pr.2015.160
   Sinaiko AR, 2005, CIRCULATION, V111, P1985, DOI 10.1161/01.CIR.0000161837.23846.57
   Song YM, 2020, EAT WEIGHT DISORD-ST, V25, P545, DOI 10.1007/s40519-019-00640-9
   Soujanya KV, 2022, J FOOD BIOCHEM, V46, DOI 10.1111/jfbc.14257
   Steenkamp LR, 2017, J AFFECT DISORDERS, V219, P193, DOI 10.1016/j.jad.2017.04.042
   Swartz MC, 2016, J ADOLESC YOUNG ADUL, V5, P278, DOI 10.1089/jayao.2015.0058
   Mitjavila MT, 2013, CLIN NUTR, V32, P172, DOI 10.1016/j.clnu.2012.08.002
   Torris C, 2018, NUTRIENTS, V10, DOI 10.3390/nu10070952
   Vacca M, 2021, FRONT PSYCHOL, V12, DOI 10.3389/fpsyg.2021.580943
   Vainik U, 2019, EUR J NEUROSCI, V50, P2430, DOI 10.1111/ejn.14352
   van 't Erve TJ, 2017, REDOX BIOL, V12, P582, DOI 10.1016/j.redox.2017.03.024
   Vega JA, 2016, ANN NUTR METAB, V68, P35, DOI 10.1159/000439092
   Whitehead SJ, 2014, ANN CLIN BIOCHEM, V51, P54, DOI 10.1177/0004563213482890
   Wu D, 2013, CHINESE MED J-PEKING, V126, P4019, DOI 10.3760/cma.j.issn.0366-6999.20131841
   Wu HC, 2020, FREE RADICAL RES, V54, P431, DOI 10.1080/10715762.2020.1798001
   Wu WH, 2006, EUR J CLIN NUTR, V60, P386, DOI 10.1038/sj.ejcn.1602328
   Yu J, 2023, ADV BIOL-GER, V7, DOI 10.1002/adbi.202200234
   Zimmet P, 2007, PEDIATR DIABETES, V8, P299, DOI 10.1111/j.1399-5448.2007.00271.x
NR 91
TC 5
Z9 5
U1 3
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PY 2023
VL 10
AR 1216445
DI 10.3389/fnut.2023.1216445
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA IZ6O9
UT WOS:001170208600001
PM 37789897
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wang, PW
   Kuo, HM
   Huang, HT
   Chang, AYW
   Weng, SW
   Tai, MH
   Chuang, JH
   Chen, IY
   Huang, SC
   Lin, TK
   Liou, CW
AF Wang, Pei-Wen
   Kuo, Hsiao-Mei
   Huang, Hung-Tu
   Chang, Alice Y. W.
   Weng, Shao-Wen
   Tai, Ming-Hong
   Chuang, Jiin-Haur
   Chen, I-Ya
   Huang, Shun-Chen
   Lin, Tsu-Kung
   Liou, Chia-Wei
TI Biphasic Response of Mitochondrial Biogenesis to Oxidative Stress in
   Visceral Fat of Diet-Induced Obesity Mice
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Article
ID INSULIN-RESISTANCE SYNDROME; SUBCUTANEOUS ADIPOSE-TISSUE; TYPE-2
   DIABETES-MELLITUS; C-REACTIVE PROTEIN; METABOLIC SYNDROME; CHRONIC
   INFLAMMATION; NONALCOHOLIC STEATOHEPATITIS; CARDIOVASCULAR-DISEASE;
   CARDIOMETABOLIC RISK; GLUCOSE-METABOLISM
AB Aims: Studies in skeletal muscle demonstrate a strong association of mitochondrial dysfunction with insulin resistance (IR). However, there is still a paucity of knowledge regarding the alteration of mitochondria in adipose tissue (AT) in the pathogenesis of IR in obesity. We investigated the mitochondrial biogenesis in visceral fat (VF) and subcutaneous fat (SF) in C57BL/6J mice fed a high-fat high-sucrose diet for 12 months. Results: Impairment of glucose tolerance and insulin sensitivity developed after 1 month of the diet and was associated with a prompt increase of VF. The VF adipocytes were larger than those in the SF and had increased expressions of HIF-1 and p-NFB p65. However, the alteration of mitochondrial biogenesis did not occur in the early stage when increased intracellular reactive oxygen species (ROS), mitochondrial oxygen consumption rate, and mitochondrial ROS emerged at the 1st, 2nd and 2nd month, respectively. Until the 6th month, the VF had markedly increased mitochondrial DNA content and expression of PGC-1, Tfam, ATP5A, and MnSOD. This increase of mitochondrial biogenesis was followed by a generalized decrease at the 12th month and the mitochondrial morphology altered markedly. In the late stage, although mitochondrial ROS decreased, the increased expression of 8-OHdG in VF continued. Innovation and Conclusion: These data suggest that IR and ROS production occur before the biphasic changes of mitochondrial biogenesis in AT, and the VF plays a more crucial role. Antioxid. Redox Signal. 20, 2572-2588.
C1 [Wang, Pei-Wen; Kuo, Hsiao-Mei; Weng, Shao-Wen; Chen, I-Ya] Chang Gung Univ, Coll Med, Dept Internal Med, Kaohsiung Chang Gung Mem Hosp, Kaohsiung 83301, Taiwan.
   [Huang, Hung-Tu] Kaohsiung Med Univ, Sch Med, Coll Med, Dept Anat, Kaohsiung, Taiwan.
   [Chang, Alice Y. W.] Chang Gung Univ, Coll Med, Ctr Translat Res Biomed Sci, Kaohsiung Chang Gung Mem Hosp, Kaohsiung 83301, Taiwan.
   [Tai, Ming-Hong] Natl Sun Yat Sen Univ, Dept Biol Sci, Inst Biomed Sci, Kaohsiung 80424, Taiwan.
   [Chuang, Jiin-Haur] Chang Gung Univ, Coll Med, Dept Surg, Kaohsiung Chang Gung Mem Hosp, Kaohsiung 83301, Taiwan.
   [Huang, Shun-Chen] Chang Gung Univ, Coll Med, Dept Anat Pathol, Kaohsiung Chang Gung Mem Hosp, Kaohsiung 83301, Taiwan.
   [Lin, Tsu-Kung; Liou, Chia-Wei] Chang Gung Univ, Coll Med, Dept Neurol, Kaohsiung Chang Gung Mem Hosp, Kaohsiung 83301, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Kaohsiung Medical
   University; Chang Gung University; Chang Gung Memorial Hospital;
   National Sun Yat Sen University; Chang Gung Memorial Hospital; Chang
   Gung University; Chang Gung University; Chang Gung Memorial Hospital;
   Chang Gung Memorial Hospital; Chang Gung University
RP Lin, TK (corresponding author), Chang Gung Univ, Coll Med, Dept Neurol, Kaohsiung Chang Gung Mem Hosp, 123 Ta Pei Rd, Kaohsiung 83301, Taiwan.
EM tklin@adm.cgmh.org.tw; cwliou@ms22.hinet.net
RI Weng, Shape wen/GYU-9746-2022; Tsai, Ming/ABA-9806-2020; Chen,
   Shih-Hong/AAG-1525-2021
FU National Science Council (Republic of China) [NSC-96-2628-B-182-001-MY2,
   98-2314-B-182-007-MY3]; Chang Gung University College of Medicine and
   Kaohsiung Chang Gung Memorial Hospital [CMRPG850263, CMRPG891111,
   CMRPG891112, CMRPG891113]
FX This work was supported by grants NSC-96-2628-B-182-001-MY2 and
   98-2314-B-182-007-MY3 from the National Science Council (Republic of
   China) and grants CMRPG850263, CMRPG891111, CMRPG891112, and CMRPG891113
   from the Chang Gung University College of Medicine and Kaohsiung Chang
   Gung Memorial Hospital. The authors are grateful to Miss Shui-Chin Lu
   and Miss Huey-Ju Lee for their technical assistance in transmission
   electron microscopy.
CR Abais JM, 2013, ANTIOXID REDOX SIGN, V18, P1537, DOI 10.1089/ars.2012.4666
   André L, 2011, BASIC RES CARDIOL, V106, P1235, DOI 10.1007/s00395-011-0211-y
   Bays H, 2004, J CLIN ENDOCR METAB, V89, P463, DOI 10.1210/jc.2003-030723
   Berg AH, 2005, CIRC RES, V96, P939, DOI 10.1161/01.RES.0000163635.62927.34
   Bonnard C, 2008, J CLIN INVEST, V118, P789, DOI 10.1172/JCI32601
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Ceriello A, 2009, J CLIN ENDOCR METAB, V94, P410, DOI 10.1210/jc.2008-1824
   Chitturi S, 2002, HEPATOLOGY, V35, P373, DOI 10.1053/jhep.2002.30692
   Côté M, 2005, J CLIN ENDOCR METAB, V90, P1434, DOI 10.1210/jc.2004-1711
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Després JP, 2001, BMJ-BRIT MED J, V322, P716, DOI 10.1136/bmj.322.7288.716
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Goodpaster BH, 2001, J CLIN ENDOCR METAB, V86, P5755, DOI 10.1210/jc.86.12.5755
   HAFFNER SM, 1992, DIABETES, V41, P715, DOI 10.2337/diabetes.41.6.715
   Harris JM, 2013, BLOOD, V121, P2483, DOI 10.1182/blood-2012-12-471201
   Hoehn KL, 2009, P NATL ACAD SCI USA, V106, P17787, DOI 10.1073/pnas.0902380106
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Kahn BB, 2000, J CLIN INVEST, V106, P473, DOI 10.1172/JCI10842
   Kim JK, 2000, J BIOL CHEM, V275, P8456, DOI 10.1074/jbc.275.12.8456
   Kim SY, 2010, CANCER LETT, V295, P236, DOI 10.1016/j.canlet.2010.03.006
   Kuk JL, 2006, OBESITY, V14, P336, DOI 10.1038/oby.2006.43
   Lee HC, 2000, BIOCHEM J, V348, P425, DOI 10.1042/0264-6021:3480425
   Lee HC, 2005, INT J BIOCHEM CELL B, V37, P822, DOI 10.1016/j.biocel.2004.09.010
   Lemieux I, 2001, ARTERIOSCL THROM VAS, V21, P961, DOI 10.1161/01.ATV.21.6.961
   Liu JK, 2010, J CLIN ENDOCR METAB, V95, P5419, DOI 10.1210/jc.2010-1378
   Marchesini G, 2001, DIABETES, V50, P1844, DOI 10.2337/diabetes.50.8.1844
   Morten KJ, 2013, J PATHOL, V229, P755, DOI 10.1002/path.4159
   Newsholme P, 2007, J PHYSIOL-LONDON, V583, P9, DOI 10.1113/jphysiol.2007.135871
   Otto TC, 2005, CRIT REV BIOCHEM MOL, V40, P229, DOI 10.1080/10409230591008189
   Pagano G, 2002, HEPATOLOGY, V35, P367, DOI 10.1053/jhep.2002.30690
   Papandreou I, 2006, CELL METAB, V3, P187, DOI 10.1016/j.cmet.2006.01.012
   Patti ME, 2003, P NATL ACAD SCI USA, V100, P8466, DOI 10.1073/pnas.1032913100
   Petersen KF, 2004, NEW ENGL J MED, V350, P664, DOI 10.1056/NEJMoa031314
   Piché MÉ, 2005, AM J CARDIOL, V96, P92, DOI 10.1016/j.amjcard.2005.02.051
   Pittas AG, 2004, J CLIN ENDOCR METAB, V89, P447, DOI 10.1210/jc.2003-031005
   Porter SA, 2009, DIABETES CARE, V32, P1068, DOI 10.2337/dc08-2280
   Ravussin E, 2002, ANN NY ACAD SCI, V967, P363
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Rector RS, 2010, J HEPATOL, V52, P727, DOI 10.1016/j.jhep.2009.11.030
   Rösen P, 2001, DIABETES-METAB RES, V17, P189, DOI 10.1002/dmrr.196
   ROWLATT C, 1976, Laboratory Animals (London), V10, P419, DOI 10.1258/002367776780956917
   Samuel VT, 2010, LANCET, V375, P2267, DOI 10.1016/S0140-6736(10)60408-4
   Sanyal AJ, 2001, GASTROENTEROLOGY, V120, P1183, DOI 10.1053/gast.2001.23256
   Schenk S, 2008, J CLIN INVEST, V118, P2992, DOI 10.1172/JCI34260
   Schroedl C, 2002, AM J PHYSIOL-LUNG C, V283, pL922, DOI 10.1152/ajplung.00014.2002
   Seppälä-Lindroos A, 2002, J CLIN ENDOCR METAB, V87, P3023, DOI 10.1210/jc.87.7.3023
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Smith JD, 2012, J CLIN ENDOCR METAB, V97, P1517, DOI 10.1210/jc.2011-2550
   Sun K, 2011, J CLIN INVEST, V121, P2094, DOI 10.1172/JCI45887
   Trevisan M, 1998, AM J EPIDEMIOL, V148, P958
   Wang PW, 2008, DIABETES RES CLIN PR, V81, P202, DOI 10.1016/j.diabres.2008.04.014
   Wei YH, 1998, ANN NY ACAD SCI, V854, P155, DOI 10.1111/j.1749-6632.1998.tb09899.x
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Weng SW, 2009, DIABETES RES CLIN PR, V83, P94, DOI 10.1016/j.diabres.2008.10.002
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Ye J, 2009, INT J OBESITY, V33, P54, DOI 10.1038/ijo.2008.229
   Ye JP, 2007, AM J PHYSIOL-ENDOC M, V293, pE1118, DOI 10.1152/ajpendo.00435.2007
   Yusuf S, 2005, LANCET, V366, P1640, DOI 10.1016/S0140-6736(05)67663-5
   Zarbin MA, 2012, WIRES NANOMED NANOBI, V4, P113, DOI 10.1002/wnan.167
NR 63
TC 30
Z9 32
U1 0
U2 15
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD JUN 1
PY 2014
VL 20
IS 16
BP 2572
EP 2588
DI 10.1089/ars.2013.5334
PG 17
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA AG9SM
UT WOS:000335760000007
PM 24111683
OA Green Published
DA 2025-06-11
ER

PT J
AU Di Giuseppe, M
   Conversano, C
AF Di Giuseppe, Mariagrazia
   Conversano, Ciro
TI Psychological components of chronic diseases: the link between defense
   mechanisms and alexithymia
SO MEDITERRANEAN JOURNAL OF CLINICAL PSYCHOLOGY
LA English
DT Article
DE Chronic diseases; Psychosomatics; Emotion regulation; Alexithymia;
   Defense mechanisms
ID METABOLIC SYNDROME; CANCER-PATIENTS; BREAST-CANCER; CHRONIC PAIN;
   DEPRESSION; CHILDHOOD; HEALTH; IMPACT; PERSONALITY; STRESS
C1 [Di Giuseppe, Mariagrazia] Univ Roma Tor Vergata, Dept Hist Culture & Soc, Rome, Italy.
   [Conversano, Ciro] Univ Pisa, Dept Surg Med & Mol Pathol, Crit & Care Med, Pisa, Italy.
C3 University of Rome Tor Vergata; University of Pisa
RP Di Giuseppe, M (corresponding author), Univ Roma Tor Vergata, Dept Hist Culture & Soc, Rome, Italy.
EM mariagrazia.di.giuseppe@uniroma2.it
RI Di+Giuseppe, Mariagrazia/AFK-3211-2022; Conversano, Ciro/ABE-1007-2020
OI Di Giuseppe, Mariagrazia/0000-0002-0373-4523
CR BAGBY RM, 1994, J PSYCHOSOM RES, V38, P23, DOI 10.1016/0022-3999(94)90005-1
   Barbosa F, 2011, COMPR PSYCHIAT, V52, P754, DOI 10.1016/j.comppsych.2010.11.004
   Barchetta S, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18136696
   Barrera I, 2014, INT REV PSYCHIATR, V26, P31, DOI 10.3109/09540261.2013.864259
   Bèkès V, 2021, MEDITERR J CLIN PSYC, V9, DOI 10.13129/2282-1619/mjcp-3107
   Beresford TP, 2006, PSYCHOSOMATICS, V47, P247, DOI 10.1176/appi.psy.47.3.247
   Bogutyn T, 1999, PSYCHOL REP, V84, P183, DOI 10.2466/PR0.84.1.183-187
   Boldrini T, 2020, SCHIZOPHR RES, V222, P209, DOI 10.1016/j.schres.2020.05.052
   Boscarino JA, 2009, J NERV MENT DIS, V197, P461, DOI 10.1097/NMD.0b013e3181a61f3e
   Brown RL, 2022, FRONT PSYCHOL, V13, DOI 10.3389/fpsyg.2022.879166
   Catalano A, 2018, J CLIN TRANSL ENDOCR, V13, P9, DOI 10.1016/j.jcte.2018.05.004
   Catalano A, 2020, AGING CLIN EXP RES, V32, P2251, DOI 10.1007/s40520-019-01426-w
   Conversano C, 2020, CLIN NEUROPSYCHIATR, V17, P217, DOI 10.36131/cnfioritieditore20200403
   Davis CR, 2014, METABOLISM, V63, P199, DOI 10.1016/j.metabol.2013.08.013
   Di Giuseppe M, 2020, MEDITERR J CLIN PSYC, V8, DOI 10.6092/2282-1619/mjcp-2515
   Di Giuseppe M, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph191912690
   Di Giuseppe M, 2021, FRONT PSYCHOL, V12, DOI 10.3389/fpsyg.2021.802602
   Di Giuseppe M, 2021, FRONT PSYCHOL, V12, DOI 10.3389/fpsyg.2021.718440
   Di Giuseppe M, 2014, J CLIN PSYCHOL, V70, P452, DOI 10.1002/jclp.22089
   Eftekhari A, 2009, ANXIETY STRESS COPIN, V22, P571, DOI 10.1080/10615800802179860
   Eikeseth FF, 2020, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.558145
   EYSENCK HJ, 1994, ADV BEHAV RES THER, V16, P167, DOI 10.1016/0146-6402(94)00001-8
   Fiegl S, 2019, FRONT PSYCHOL, V10, DOI 10.3389/fpsyg.2019.01862
   Galli F, 2019, PAIN RES MANAG, V2019, DOI 10.1155/2019/1874078
   Gangemi S, 2021, MEDITERR J CLIN PSYC, V9, DOI 10.13129/2282-1619/mjcp-3245
   Gatchel RJ, 2004, AM PSYCHOL, V59, P795, DOI 10.1037/0003-066X.59.8.795
   GREER S, 1975, J PSYCHOSOM RES, V19, P147, DOI 10.1016/0022-3999(75)90062-8
   Gugliandolo MC, 2020, J CHILD FAM STUD, V29, P2453, DOI 10.1007/s10826-020-01779-1
   Gyurak A, 2011, COGNITION EMOTION, V25, P400, DOI 10.1080/02699931.2010.544160
   HEIM E, 1978, PSYCHOTHER PSYCHOSOM, V30, P1, DOI 10.1159/000287278
   Helmes E, 2008, J CLIN PSYCHOL, V64, P318, DOI 10.1002/jclp.20461
   Hyphantis T, 2016, DIGEST DIS SCI, V61, P273, DOI 10.1007/s10620-015-3843-1
   Hyphantis T, 2013, J PSYCHOSOM RES, V75, P362, DOI 10.1016/j.jpsychores.2013.08.014
   Hyphantis T, 2011, J PSYCHOSOM RES, V70, P411, DOI 10.1016/j.jpsychores.2010.09.011
   Kelly RR, 2020, FRONT PSYCHOL, V11, DOI 10.3389/fpsyg.2020.612366
   Kesebir S, 2014, WORLD J CLIN CASES, V2, P332, DOI 10.12998/wjcc.v2.i8.332
   Kessler RC, 2013, ANNU REV PUBL HEALTH, V34, P119, DOI 10.1146/annurev-publhealth-031912-114409
   Koole SL, 2011, COGNITION EMOTION, V25, P389, DOI 10.1080/02699931.2010.550505
   Kreitler S., 1993, PSYCHO-ONCOLOGY, V2, P43
   Leweke F, 2012, PSYCHOPATHOLOGY, V45, P22, DOI 10.1159/000325170
   Lewis M, 2003, CHILD ADOL PSYCH CL, V12, P389, DOI 10.1016/S1056-4993(03)00024-5
   Li L, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-024079
   Lumley MA, 2005, EMOTION, V5, P329, DOI 10.1037/1528-3542.5.3.329
   Ma Y, 2021, BMC PSYCHIATRY, V21, DOI 10.1186/s12888-021-03428-3
   Marchini F, 2021, PSYCHOANAL PSYCHOTHE, V35, P5, DOI 10.1080/02668734.2021.1922492
   Martini PS, 2004, COMPR PSYCHIAT, V45, P483, DOI 10.1016/j.comppsych.2004.07.012
   Martino G, 2021, MEDITERR J CLIN PSYC, V9, DOI 10.13129/2282-1619/mjcp-3072
   Martino G, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18158144
   Martino G, 2021, FRONT PSYCHOL, V12, DOI 10.3389/fpsyg.2021.667237
   Martino G, 2019, MEDITERR J CLIN PSYC, V7, DOI 10.6092/2282-1619/2019.7.2167
   Mnif L, 2014, ANN ENDOCRINOL-PARIS, V75, P213, DOI 10.1016/j.ando.2014.06.001
   Myles L, 2022, PSYCHIATR PSYCHOL KL, V22, P40, DOI 10.15557/PiPK.2022.0005
   Myles L, 2022, INT J PSYCHOL RES, V15, P126, DOI 10.21500/20112084.5400
   Perry J.C., 2004, ADV PSYCHOL 136 DEFE, P165, DOI [10.1016/S0166-4115(04)80034-7, DOI 10.1016/S0166-4115(04)80034-7]
   Perry J.C., 1990, DEFENSE MECH RATING
   Perry JC, 2014, J CLIN PSYCHOL, V70, P406, DOI 10.1002/jclp.22085
   Pervanidou P, 2012, METABOLISM, V61, P611, DOI 10.1016/j.metabol.2011.10.005
   Péterfalvi A, 2019, FRONT PSYCHOL, V10, DOI 10.3389/fpsyg.2019.01798
   Porcerelli JH, 2017, J NERV MENT DIS, V205, P466, DOI 10.1097/NMD.0000000000000674
   Prout TA, 2022, J PERS ASSESS, V104, P833, DOI 10.1080/00223891.2021.2019053
   Rich-Edwards JW, 2012, CIRCULATION, V126, P920, DOI 10.1161/CIRCULATIONAHA.111.076877
   Rock PL, 2014, PSYCHOL MED, V44, P2029, DOI 10.1017/S0033291713002535
   Rymarczyk K, 2020, FRONT PSYCHOL, V11, DOI 10.3389/fpsyg.2020.552740
   Saariaho AS, 2013, GEN HOSP PSYCHIAT, V35, P239, DOI 10.1016/j.genhosppsych.2012.11.011
   Sardella A, 2021, FRONT PSYCHOL, V11, DOI 10.3389/fpsyg.2020.621013
   Settineri S, 2019, FRONT PSYCHOL, V10, DOI 10.3389/fpsyg.2019.01897
   Shen XY, 2021, PSYCHOL RES BEHAV MA, V14, P1281, DOI 10.2147/PRBM.S315930
   Shinkov A, 2018, POSTGRAD MED, V130, P251, DOI 10.1080/00325481.2018.1410054
   Stanton A. L., 2017, PSYCHOL ADJUSTMENT C, DOI [10.1201/9781315155074-5, DOI 10.1201/9781315155074-5]
   Talepasand S, 2018, INT J CANCER MANAG, V11, DOI 10.5812/ijcm.11116
   Tanzilli A, 2020, J PERS DISORD, V34, P42, DOI 10.1521/pedi.2020.34.supp.42
   Tanzilli A, 2020, J PERS ASSESS, V102, P616, DOI 10.1080/00223891.2019.1674318
   Turner J, 2000, WESTERN J MED, V172, P124, DOI 10.1136/ewjm.172.2.124
   Vicario CM, 2020, FRONT PSYCHOL, V11, DOI 10.3389/fpsyg.2020.01893
   Vita R, 2020, MEDITERR J CLIN PSYC, V8, DOI 10.6092/2282-1619/mjcp-2521
   Weihs KL, 2000, J PSYCHOSOM RES, V49, P59, DOI 10.1016/S0022-3999(00)00143-4
   Willemsen R, 2008, INT J DERMATOL, V47, P903, DOI 10.1111/j.1365-4632.2008.03726.x
   Wooten T, 2019, NEUROPSYCHOLOGY, V33, P947, DOI 10.1037/neu0000554
   Yaffe K, 2009, ARCH NEUROL-CHICAGO, V66, P324, DOI 10.1001/archneurol.2008.566
   Yates KF, 2012, ARTERIOSCL THROM VAS, V32, P2060, DOI 10.1161/ATVBAHA.112.252759
   Yonatan-Leus R, 2021, CLIN PSYCHOL PSYCHOT, V28, P642, DOI 10.1002/cpp.2527
   Yoo J, 2019, FRONT PSYCHOL, V10, DOI 10.3389/fpsyg.2019.02746
   Zimmerman TN, 2019, PSYCHOANAL PSYCHOL, V36, P259, DOI 10.1037/pap0000225
NR 83
TC 18
Z9 18
U1 0
U2 7
PU UNIV STUDI MESSINA
PI MESSINA
PA VIA DEI VERDI, MESSINA, 98122, ITALY
SN 2282-1619
J9 MEDITERR J CLIN PSYC
JI Mediterr. J. Clin. Psychol.
PY 2022
VL 10
IS 3
BP 27
EP 27
DI 10.13129/2282-1619/mjcp-3602
PG 1
WC Psychology, Clinical
WE Emerging Sources Citation Index (ESCI)
SC Psychology
GA 7M8CA
UT WOS:000906878200003
DA 2025-06-11
ER

PT J
AU Magnavita, N
AF Magnavita, Nicola
TI Headache in the Workplace: Analysis of Factors Influencing Headaches in
   Terms of Productivity and Health
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE anxiety; depression; metabolic syndrome; leadership; effort; reward;
   sleep; workplace health promotion; medical surveillance; headache
   disorders
ID PSYCHOSOCIAL FACTORS; RISK-FACTORS; NECK PAIN; WORK; MIGRAINE; STRESS;
   IMPACT; ENVIRONMENTS; INSTRUMENT; MANAGEMENT
AB Headache is a very common condition that can have a significant impact on work. This study aimed to assess the prevalence of headaches and their impact on a sample of 1076 workers from 18 small companies operating in different sectors. The workers who volunteered to participate were asked to fill in the Headache Impact Test-6 (HIT-6) and answer questions designed to assess stressful and traumatic factors potentially associated with headaches. The volunteers subsequently underwent a medical examination and tests for diagnosing metabolic syndrome. Out of the 1044 workers who completed the questionnaire (participation rate = 97%), 509 (48.8%) reported suffering from headaches. In a multivariate logistic regression model, female gender, recent bereavement, intrusive leadership, and sleep problems were significantly associated with headaches. In univariate logistic regression models, headache intensity was associated with an increased risk of anxiety (OR 1.10; CI95% 1.09; 1.12) and depression (OR 1.09; CI95% 1.08; 1.11). Headache impact was also associated with the risk of metabolic syndrome (OR 1.02; CI95% 1.00, 1.04), obesity (OR 1.02, CI95% 1.01; 1.03), and reduced HDL cholesterol (OR 1.03; CI95% 1.01; 1.04). The impact of headache calls for intervention in the workplace not only to promote a prompt diagnosis of the different forms of headaches but also to improve work organization, leadership style, and the quality of sleep.
C1 [Magnavita, Nicola] Univ Cattolica Sacro Cuore, Postgrad Sch Occupat Hlth, Largo F Vito 1, I-00168 Rome, Italy.
   [Magnavita, Nicola] A Gemelli Fdn IRCCS, Dept Sci Woman Child & Publ Hlth, Largo A Gemelli 8, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Magnavita, N (corresponding author), Univ Cattolica Sacro Cuore, Postgrad Sch Occupat Hlth, Largo F Vito 1, I-00168 Rome, Italy.; Magnavita, N (corresponding author), A Gemelli Fdn IRCCS, Dept Sci Woman Child & Publ Hlth, Largo A Gemelli 8, I-00168 Rome, Italy.
EM nicolamagnavita@gmail.com
RI Magnavita, Nicola/J-6074-2014
CR Aegerter AM, 2020, BMC MUSCULOSKEL DIS, V21, DOI 10.1186/s12891-020-03388-x
   Ailani J, 2021, CURR OPIN NEUROL, V34, P339, DOI 10.1097/WCO.0000000000000926
   Appel AM, 2020, INT ARCH OCC ENV HEA, V93, P601, DOI 10.1007/s00420-019-01512-6
   Arnetz JE, 1998, WORK STRESS, V12, P17, DOI 10.1080/02678379808256846
   Assarzadegan F, 2019, J FAM MED PRIM CARE, V8, P950, DOI 10.4103/jfmpc.jfmpc_9_19
   Bank G, 2020, BEHAV NEUROL, V2020, DOI 10.1155/2020/7351214
   Bayliss M, 2002, The HIT-6TM: a user's guide.
   de Dhaem OB, 2021, CEPHALALGIA, V41, P760, DOI 10.1177/0333102420977852
   Bolcato M, 2021, HEALTHCARE-BASEL, V9, DOI 10.3390/healthcare9010017
   Burch RC, 2019, NEUROL CLIN, V37, P631, DOI 10.1016/j.ncl.2019.06.001
   Burton WN, 2016, J OCCUP ENVIRON MED, V58, P790, DOI 10.1097/JOM.0000000000000781
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1016/0165-1781(89)90047-4
   Caponnetto V, 2021, J HEADACHE PAIN, V22, DOI 10.1186/s10194-021-01281-z
   Charkiewicz AE, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17124385
   Christensen JO, 2021, J OCCUP ENVIRON MED, V63, P151, DOI 10.1097/JOM.0000000000002103
   Chu HT, 2018, HEADACHE, V58, P407, DOI 10.1111/head.13215
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   COOK NR, 1989, ARCH NEUROL-CHICAGO, V46, P1338, DOI 10.1001/archneur.1989.00520480082024
   Curcio G, 2013, NEUROL SCI, V34, P511, DOI 10.1007/s10072-012-1085-y
   Dostalova Nicol, 2021, Cas Lek Cesk, V160, P88
   Einhorn Daniel, 2003, Endocr Pract, V9, P237
   Fiane I, 2006, CEPHALALGIA, V26, P960, DOI 10.1111/j.1468-2982.2006.01151.x
   Ghislieri C, 2017, FRONT PSYCHOL, V8, DOI 10.3389/fpsyg.2017.01070
   GOLDBERG D, 1988, BMJ-BRIT MED J, V297, P897, DOI 10.1136/bmj.297.6653.897
   Hämmig O, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-435
   Heus P, 2018, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009877.pub2
   Hjalte F, 2019, J HEADACHE PAIN, V20, DOI 10.1186/s10194-019-1015-y
   Huntsman DD, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19042248
   International Diabetes Foundation IDF, 2006, IDF CONS WORLDW DEF
   Jahromi SR, 2019, J HEADACHE PAIN, V20, DOI 10.1186/s10194-019-1057-1
   James SL, 2018, LANCET, V392, P1789, DOI [10.1016/s0140-6736(18)32335-3, 10.1016/S0140-6736(18)32335-3]
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Kawata AK, 2005, HEADACHE, V45, P638, DOI 10.1111/j.1526-4610.2005.05130.x
   Kim HR, 2022, WORKPLACE HEALTH SAF, V70, P161, DOI 10.1177/21650799211023863
   Kosinski M, 2003, QUAL LIFE RES, V12, P963, DOI 10.1023/A:1026119331193
   Kumar S, 2021, FRONT PSYCHOL, V12, DOI 10.3389/fpsyg.2021.577529
   Kuo WY, 2015, J HEADACHE PAIN, V16, DOI 10.1186/s10194-015-0585-6
   Lamke D, 2014, J HOLIST NURS, V32, P278, DOI 10.1177/0898010114531906
   Lardon A, 2017, CEPHALALGIA, V37, P64, DOI 10.1177/0333102416636096
   Lebedeva ER, 2017, CEPHALALGIA, V37, P1264, DOI 10.1177/0333102416678389
   Lee DW, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18147589
   Lever I, 2019, J ADV NURS, V75, P3195, DOI 10.1111/jan.13986
   Lewis SR, 2018, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD012455.pub2
   Liu H, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2019-032239
   Luedtke K, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2019-029855
   Magnavita N, 2014, MED LAV, V105, P269
   Magnavita N, 2014, MED LAV, V105, P174
   Magnavita N, 2007, G Ital Med Lav Ergon, V29, P670
   Magnavita N, 2007, G Ital Med Lav Ergon, V29, P667
   Magnavita N., 2021, TRAUMA CARE, V1, P66, DOI [10.3390/traumacare1020007, DOI 10.3390/TRAUMACARE1020007]
   Magnavita N, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18189888
   Magnavita N, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18147316
   Magnavita N, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18073330
   Magnavita N, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17218245
   Magnavita N, 2020, HEADACHE, V60, P1444, DOI 10.1111/head.13882
   Magnavita N, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17145218
   Magnavita N, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15061096
   Magnavita N, 2015, INT ARCH OCC ENV HEA, V88, P185, DOI 10.1007/s00420-014-0952-7
   Magnavita N, 2012, SCI WORLD J, DOI 10.1100/2012/372852
   Magri CA, 2021, WORK, V70, P815, DOI 10.3233/WOR-205179
   Mahmoud AN, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2017-020498
   Malmberg-Ceder K, 2019, J PAIN RES, V12, P1733, DOI 10.2147/JPR.S165263
   Martin M, 2004, J CLIN EPIDEMIOL, V57, P1271, DOI 10.1016/j.jclinepi.2004.05.004
   Min JY, 2014, AM J IND MED, V57, P87, DOI 10.1002/ajim.22233
   Molina-Torres G, 2019, BEHAV PHARMACOL, V30, P187, DOI 10.1097/FBP.0000000000000478
   Monzani L, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0201189
   Olesen J, 2018, CEPHALALGIA, V38, P1, DOI 10.1177/0333102417738202
   Pachito DV, 2018, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD012243.pub2
   Ramirez-Moreno JM, 2021, OCCUP ENVIRON MED, V78, P548, DOI 10.1136/oemed-2020-106956
   Rangel TC, 2021, SLEEP MED, V88, P241, DOI 10.1016/j.sleep.2021.10.029
   Robbins MS, 2021, JAMA-J AM MED ASSOC, V325, P1874, DOI 10.1001/jama.2021.1640
   Rota E, 2016, EUR J PHYS REHAB MED, V52, P457
   Sandoe CH, 2019, HEADACHE, V59, P1631, DOI 10.1111/head.13622
   Sayan HE, 2021, MED LAV, V112, P153, DOI 10.23749/mdl.v112i2.11012
   Saylor D, 2018, SEMIN NEUROL, V38, P182, DOI 10.1055/s-0038-1646946
   Schmidt A.A., 2008, DEV VALIDATION TOXIC
   Scopetti M, 2021, INT J QUAL HEALTH C, V33, DOI 10.1093/intqhc/mzaa085
   Shimizu T, 2021, J HEADACHE PAIN, V22, DOI 10.1186/s10194-021-01243-5
   Siegrist J, 2009, INT ARCH OCC ENV HEA, V82, P1005, DOI 10.1007/s00420-008-0384-3
   Song TJ, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0165316
   Taylor FR, 2015, HEADACHE, V55, P1028, DOI 10.1111/head.12620
   Tynes T, 2013, J OCCUP ENVIRON MED, V55, P1436, DOI 10.1097/JOM.0b013e3182a7e678
   Urhammet C, 2020, J OCCUP ENVIRON MED, V62, pE636, DOI 10.1097/JOM.0000000000002023
   Viana M, 2020, EUR J NEUROL, V27, P536, DOI 10.1111/ene.14098
   Vicente Herrero María Teófila, 2021, Arch Prev Riesgos Labor, V24, P20, DOI 10.12961/aprl.2021.24.01.03
   Westgate CSJ, 2021, J HEADACHE PAIN, V22, DOI 10.1186/s10194-021-01337-0
   Yang M, 2011, CEPHALALGIA, V31, P357, DOI 10.1177/0333102410379890
   Zaffina S, 2021, FRONT HUM NEUROSCI, V15, DOI 10.3389/fnhum.2021.666468
   2018, LANCET NEUROL, V17, P954
NR 89
TC 21
Z9 22
U1 1
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD MAR
PY 2022
VL 19
IS 6
AR 3712
DI 10.3390/ijerph19063712
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 0C6XF
UT WOS:000775453200001
PM 35329399
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Richter, N
   Juckel, G
   Assion, HJ
AF Richter, N.
   Juckel, G.
   Assion, H. -J.
TI Metabolic syndrome: a follow-up study of acute depressive inpatients
SO EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
LA English
DT Article
DE Depression; Metabolic syndrome; Triglycerides
ID YOUNG-ADULTS; PREVALENCE; POPULATION; SYMPTOMS; HEALTH
AB Previous studies pointed out the high prevalence of the metabolic syndrome among patients with bipolar disorder and major depression. A link between depression and a metabolic syndrome remains in dispute despite these studies. This study was conducted to evaluate the occurrence of the metabolic syndrome in depressive inpatients, to analyze the association between the severity of depression and the metabolic syndrome and to screen specific laboratory values in the course of depressive illness. 60 acute depressive patients were recruited for the study and underwent psychometric testing [21-item Hamilton Depression Rating Scale (HAMD), Beck Depression Inventory (BDI), Clinical Global Impression Scale (CGI) and Global Assessment of Functioning Scale (GAF)] and a metabolic syndrome screening using the modified criteria of the American National Cholesterol Education Program (NCEP) Treatment Panel III (ATP III). Moreover, CRP, cholesterol, HDL-cholesterol, fasting glucose, triglyceride and leptin levels were measured. 42 patients were reexamined in state of (partial) remission. Depression was reassessed using the 21-item HAMD, and laboratory values were analyzed a second time. 25% of the depressive patients fulfilled the criteria of metabolic syndrome (MS+). Only in the MS+ group, a positive correlation between triglyceride blood levels and severity of depression became evident as well in the state of acute depression as in the state of remission. In the group of patients without metabolic syndrome, laboratory values were not associated with severity of depression. An association between metabolic parameters and the course of depression could only be detected in the group of patients with metabolic syndrome. These findings suggest that, in these patients, a beneficial outcome of depressive illness may improve the metabolic situation.
C1 [Richter, N.; Juckel, G.; Assion, H. -J.] Ruhr Univ Bochum, Dept Psychiat & Psychotherapy, LWL Hosp Bochum, D-44791 Bochum, Germany.
C3 Ruhr University Bochum
RP Assion, HJ (corresponding author), Ruhr Univ Bochum, Dept Psychiat & Psychotherapy, LWL Hosp Bochum, Alexandrinenstr 1, D-44791 Bochum, Germany.
EM assion-hj@versanet.de
CR Al-Nozha MM, 2005, SAUDI MED J, V26, P1918
   Eich D, 2007, EUR ARCH PSY CLIN N, V257, P396, DOI 10.1007/s00406-007-0747-x
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   GLUECK CJ, 1993, BIOL PSYCHIAT, V34, P240, DOI 10.1016/0006-3223(93)90078-R
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Guize L, 2006, B ACAD NAT MED PARIS, V190, P685, DOI 10.1016/S0001-4079(19)33302-3
   Heiskanen TH, 2006, J CLIN PSYCHIAT, V67, P1422, DOI 10.4088/JCP.v67n0913
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   KOPF D, 2005, PSYCHONEUROENDOCRINO, V31, P212
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178, DOI 10.4088/JCP.v69n0202
   Moebus S, 2007, CARDIOVASC DIABETOL, V6, DOI 10.1186/1475-2840-6-22
   Neuhauser HK., 2005, PRAVALENZ METABOLISC
   PENTTINEN J, 1995, AM J EPIDEMIOL, V141, P716, DOI 10.1093/oxfordjournals.aje.a117492
   PJERK E, 2007, EUR ARCH PSY CLIN N, V257, P197
   Teixeira PJR, 2007, REV BRAS PSIQUIATR, V29, P330, DOI 10.1590/S1516-44462007000400007
   Sheikh N, 2004, ACTA MED IRANICA, V42, P185
   Tuomilehto J, 2005, DIABETES RES CLIN PR, V68, pS28, DOI 10.1016/j.diabres.2005.03.018
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
   Vogelzangs N, 2007, PSYCHONEUROENDOCRINO, V32, P151, DOI 10.1016/j.psyneuen.2006.11.009
NR 21
TC 44
Z9 49
U1 0
U2 4
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0940-1334
EI 1433-8491
J9 EUR ARCH PSY CLIN N
JI Eur. Arch. Psych. Clin. Neurosci.
PD FEB
PY 2010
VL 260
IS 1
BP 41
EP 49
DI 10.1007/s00406-009-0013-5
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 534AS
UT WOS:000272868500005
PM 19399357
DA 2025-06-11
ER

PT J
AU Hollander, PA
   Amod, A
   Litwak, LE
   Chaudhari, U
AF Hollander, Priscilla A.
   Amod, Aslam
   Litwak, Leon E.
   Chaudhari, Umesh
CA ARPEGGIO Study Grp
TI Effect of Rimonabant on Glycemic Control in Insulin-Treated Type 2
   Diabetes: The ARPEGGIO Trial
SO DIABETES CARE
LA English
DT Article
ID CANNABINOID-1 RECEPTOR BLOCKER; CARDIOMETABOLIC RISK-FACTORS;
   OBESE-PATIENTS; BODY-WEIGHT; EFFICACY; OVERWEIGHT
AB OBJECTIVE - To examine the efficacy and safety of rimonabant, a selective cannabinoid receptor type-1 antagonist, in patients with type 2 diabetes receiving insulin monotherapy.
   RESEARCH DESIGN AND METHODS - Patients (n = 368; A1C >= 7%) were randomized to 20 mg/day rimonabant or placebo in this 48-week, double-blind, placebo-controlled I multicenter trial. Change in baseline A1C to week 48 (primary outcome) and changes in body weight, waist circumference, and lipid levels (secondary outcomes) were assessed.
   RESULTS - Rimonabant significantly reduced baseline A1C versus placebo (-0.89 vs. -0.24% P < 0.0001), and significantly greater improvements were observed in cardiometabolic risk factors. More rimonabant. Patients achieved >10% reduction in mean total daily insulin dose versus placebo (P = 0.0012), and fewer required rescue medication (P < 0.0001). Hypoglycemia, nausea, dizziness, anxiety, and depression were more frequent with rimonabant.
   CONCLUSIONS - Rimonabant improved glycerine control and cardiometabolic risk factors in patients with type 2 diabetes receiving insulin.
C1 [Hollander, Priscilla A.] Baylor Univ, Med Ctr, Dallas, TX USA.
   [Amod, Aslam] Chatsmed Garden Hosp, Ctr Diabet Endocrinol & Metab Dis, Durban, South Africa.
   [Litwak, Leon E.] Hosp Italiano Buenos Aires, Buenos Aires, DF, Argentina.
   [Chaudhari, Umesh] Sanofi Aventis US, Bridgewater, NJ USA.
C3 Baylor University; Baylor University Medical Center; University of
   Buenos Aires; University of Buenos Aires Hospital; Hospital Italiano de
   Buenos Aires; Sanofi-Aventis; Sanofi USA
RP Hollander, PA (corresponding author), Baylor Univ, Med Ctr, Dallas, TX USA.
EM priscilh@baylorhealth.edu
FU sanofi-aventis; Roche; Novo Nordisk
FX This article was supported by sanofi-aventis.P.A.H. has served on the
   advisory boards for sanofi-aventis, Pfizer, Novo Nordisk, and Merck; is
   a consultant for Orexigen, Sankyo, and Pfizer; is on the speakers bureau
   for Pfizer, Merck, and sanofi-aventis; has received research support
   only as part Of Multicenter clinical trials. A.A. has received honoraria
   from sanofi-aventis and has served on the advisory boards for MSD, Eli
   Lilly, Servier, and Novartis. L.E.L. has served on the advisory boards
   for sanofi-aventis, Roche, Pfizer, Eli Lilly, Novo Nordisk, and
   Novartis; is a board member for Eli Lilly and sanofi-aventis; has
   received research support from Roche, sanofi-aventis, and Novo Nordisk.
   U.C. is an employee of sanofi-aventis U.S. No other potential conflicts
   of interest relevant to this article were reported.
CR Bloomgarden ZT, 2006, DIABETES CARE, V29, P2137, DOI 10.2337/dc06-1120
   Christensen R, 2007, LANCET, V370, P1706, DOI 10.1016/S0140-6736(07)61721-8
   DESPRES JP, 2007, 67 SCI SESS AM DIAB
   Herling AW, 2008, ENDOCRINOLOGY, V149, P2557, DOI 10.1210/en.2007-1515
   Home P, 2006, DIABETIC MED, V23, P579
   Kelley DE, 2002, DIABETES CARE, V25, P1033, DOI 10.2337/diacare.25.6.1033
   Pagotto U, 2006, ENDOCR REV, V27, P73, DOI 10.1210/er.2005-0009
   Pi-Sunyer F, 2006, JAMA-J AM MED ASSOC, V295, P761, DOI 10.1001/jama.295.7.761
   Rodbard H.W., 2007, ENDOCR PRACT, V13, P1
   Rosenstock J, 2008, DIABETES CARE, V31, P2169, DOI 10.2337/dc08-0386
   Scheen AJ, 2006, LANCET, V368, P1660, DOI 10.1016/S0140-6736(06)69571-8
   Statement P., 2007, Diabetes Care, V30, DOI [DOI 10.2337/DC07-S004, 10.2337/dc07-S004]
   Van Gaal LF, 2005, LANCET, V365, P1389, DOI 10.1016/S0140-6736(05)66374-X
   Van Gaal LF, 2008, EUR HEART J, V29, P1761, DOI 10.1093/eurheartj/ehn076
NR 14
TC 38
Z9 43
U1 0
U2 2
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD MAR
PY 2010
VL 33
IS 3
BP 605
EP 607
DI 10.2337/dc09-0455
PG 3
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 568YO
UT WOS:000275562700030
PM 20009090
OA Green Submitted, hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Glaus, J
   Vandeleur, C
   Gholam-Rezaee, M
   Castelao, E
   Perrin, M
   Rothen, S
   Bovet, P
   Marques-Vidal, P
   von Känel, R
   Merikangas, K
   Mooser, V
   Waterworth, DM
   Waeber, G
   Vollenweider, P
   Preisig, M
AF Glaus, J.
   Vandeleur, C.
   Gholam-Rezaee, M.
   Castelao, E.
   Perrin, M.
   Rothen, S.
   Bovet, P.
   Marques-Vidal, P.
   von Kaenel, R.
   Merikangas, K.
   Mooser, V.
   Waterworth, D. M.
   Waeber, G.
   Vollenweider, P.
   Preisig, M.
TI Atypical depression and alcohol misuse are related to the cardiovascular
   risk in the general population
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE depression; substance use disorders; weight gain; risk factors;
   cardio-vascular diseases
ID TEST-RETEST RELIABILITY; CORONARY-HEART-DISEASE; GENETIC-STUDIES DIGS;
   PSYCHIATRIC-DISORDERS; DIAGNOSTIC INTERVIEW; ANXIETY DISORDERS;
   MENTAL-HEALTH; OBESITY; SYMPTOMS; ASSOCIATION
AB ObjectiveThe aims of the present study were to assess the associations between mood, anxiety and substance use disorders, including their subtypes, and the prevalence of cardiovascular risk factors (CVRFs).
   MethodThorough physical investigations, biological measures and standardized interview techniques were used to assess 3716 subjects of an urban area, aged 35-66 years.
   ResultsAtypical depression was associated with increased prevalence of overweight, diabetes and the metabolic syndrome (OR=1.5, 95% C.I. 1.1-2.0; OR=2.0, 95% C.I. 1.1-3.5, OR=1.6, 95% C.I. 1.0-2.4 respectively), whereas decreased prevalence of overweight was found in melancholic (OR=0.7, 95% C.I. 0.6-0.9) and unspecified depression (OR=0.8, 95% C.I. 0.7-1.0). Alcohol abuse was associated with diabetes (OR=1.8, 95% C.I. 1.1-2.9) and dyslipidemia (OR=1.3, 95% C.I. 1.0-1.8), alcohol dependence with dyslipidemia only (OR=1.4, 95% C.I. 1.0-2.0). Almost all mental disorders were associated with a lifetime history of regular cigarette smoking, and atypical depression, alcohol misuse and drug dependence were associated with inactivity.
   ConclusionTo conclude results emphasize the need to subtype depression and to pay particular attention to the atypical subtype. Comorbid alcohol misuse may further increase the cardiovascular risk. Efforts to diminish smoking in subjects with mental disorders could be crucial measures to reduce their high incidence of cardiovascular disease.
C1 [Glaus, J.; Vandeleur, C.; Gholam-Rezaee, M.; Castelao, E.; Perrin, M.; Rothen, S.; Preisig, M.] Univ Lausanne Hosp, Dept Psychiat, Lausanne, Switzerland.
   [Bovet, P.; Marques-Vidal, P.] Univ Lausanne Hosp, Inst Social & Prevent, Lausanne, Switzerland.
   [von Kaenel, R.] Univ Hosp Bern, Dept Gen Internal Med, CH-3010 Bern, Switzerland.
   [Merikangas, K.] NIMH, Genet Epidemiol Res Branch, Intramural Res Program, Bethesda, MD 20892 USA.
   [Mooser, V.; Waterworth, D. M.] GlaxoSmithKline, Med Genet, Philadelphia, PA USA.
   [Waeber, G.; Vollenweider, P.] Univ Lausanne Hosp, Dept Internal Med, Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Bern; University Hospital of Bern; National Institutes of
   Health (NIH) - USA; NIH National Institute of Mental Health (NIMH);
   GlaxoSmithKline; Glaxosmithkline USA; University of Lausanne; Centre
   Hospitalier Universitaire Vaudois (CHUV)
RP Glaus, J (corresponding author), Univ Lausanne Hosp, Dept Psychiat, Ctr Res Psychiat Epidemiol & Psychopathol CEPP, Site Cery, CH-1008 Prilly, Switzerland.
EM jennifer.glaus@chuv.ch
RI Preisig, Martin/H-3441-2016; Rothen, Stephane/E-8325-2014; Glaus,
   Jennifer/C-7887-2017; von Kanel, Roland/B-1811-2019; Marques-Vidal,
   Pedro/C-9449-2009; Vollenweider, Peter/Q-4603-2016; Bovet,
   Pascal/F-4477-2011
OI Glaus, Jennifer/0000-0001-8883-9473; Preisig,
   Martin/0000-0001-5689-4259; von Kanel, Roland/0000-0002-8929-5129;
   Castelao, Enrique/0000-0003-1966-3683; Marques-Vidal,
   Pedro/0000-0002-4548-8500; Vandeleur, Caroline/0000-0001-9092-6648;
   Vollenweider, Peter/0000-0002-0765-896X; Merikangas,
   Kathkeen/0000-0002-4667-2414; Bovet, Pascal/0000-0002-0242-4259; Waeber,
   Gerard/0000-0003-4193-788X
FU Swiss National Science Foundation [32003B-105993, 32003B-118308,
   33CSC0-122661]; GlaxoSmithKline Clinical Genetics; Swiss National
   Science Foundation (SNF) [33CSC0-122661] Funding Source: Swiss National
   Science Foundation (SNF)
FX The authors express their gratitude to the Lausanne inhabitants who
   volunteered to participate in the PsyCoLaus study and to the
   collaborators who contributed to the coordination of the study and the
   collection of data. They also thank all the investigators of the CoLaus
   study, who made the psychiatric study possible, as well as many GSK
   employees who contributed to the execution of this study. This research
   was supported by three grants from the Swiss National Science Foundation
   (#32003B-105993, #32003B-118308 and #33CSC0-122661 to M. Preisig) and
   two grants from GlaxoSmithKline Clinical Genetics to G. Waeber, P.
   Vollenweider and M. Preisig. The funding organization played no role in
   the design or conduct of the study, the collection, management,
   analysis, or interpretation of the data; or the preparation, review, or
   approval of the manuscript.
CR Anderson SE, 2007, PSYCHOSOM MED, V69, P740, DOI 10.1097/PSY.0b013e31815580b4
   Angst J, 2006, EUR ARCH PSY CLIN N, V256, P44, DOI 10.1007/s00406-005-0600-z
   Antonijevic IA, 2006, PSYCHONEUROENDOCRINO, V31, P1, DOI 10.1016/j.psyneuen.2005.04.004
   AROMAA A, 1994, ACTA PSYCHIAT SCAND, V89, P77, DOI 10.1111/j.1600-0447.1994.tb05807.x
   Berney A, 2002, DRUG ALCOHOL DEPEN, V65, P149, DOI 10.1016/S0376-8716(01)00156-9
   Bettschart W., 1996, EVALUATION CLIN STAN, P157
   Carpenter KM, 2000, AM J PUBLIC HEALTH, V90, P251, DOI 10.2105/AJPH.90.2.251
   Chaiton MO, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-356
   De Hert M, 2009, WORLD PSYCHIATRY, V8, P15
   ENDICOTT J, 1978, ARCH GEN PSYCHIAT, V35, P837
   Firmann M, 2008, BMC CARDIOVASC DISOR, V8, DOI 10.1186/1471-2261-8-6
   Foerster M, 2009, AM J CARDIOL, V103, P361, DOI 10.1016/j.amjcard.2008.09.089
   Freeman DJ, 1984, PERINATAL EPIDEMIOLO, P357
   Ghaemi SN, 2011, ACTA PSYCHIAT SCAND, V124, P497, DOI 10.1111/j.1600-0447.2011.01746.x
   Glassman A, 2008, PHARMACOPSYCHIATRY, V41, P221, DOI 10.1055/s-2008-1058108
   Goldberg D. P., 1972, The detection of psychiatric illness by questionnaire
   Goodwin RD, 2008, J PSYCHIATR RES, V43, P239, DOI 10.1016/j.jpsychires.2008.05.006
   Grant BF, 2004, ARCH GEN PSYCHIAT, V61, P1107, DOI 10.1001/archpsyc.61.11.1107
   Halbreich U, 2006, PSYCHONEUROENDOCRINO, V31, P16, DOI 10.1016/j.psyneuen.2005.08.004
   Härter MC, 2003, EUR ARCH PSY CLIN N, V253, P313, DOI 10.1007/s00406-003-0449-y
   Hasler G, 2004, PSYCHOL MED, V34, P1047, DOI 10.1017/S0033291703001697
   Hollingshead A., 2011, Four factor index of social status, V8, P21
   John U, 2005, OBES RES, V13, P101, DOI 10.1038/oby.2005.13
   Klein DN, 2008, J ABNORM PSYCHOL, V117, P552, DOI 10.1037/0021-843X.117.3.552
   Lamers F, 2010, J CLIN PSYCHIAT, V71, P1582, DOI 10.4088/JCP.09m05398blu
   LEBOYER M, 1991, EUR ARCH PSY CLIN N, V241, P165, DOI 10.1007/BF02219716
   Leboyer M., 1995, Interview diagnostique pour les tudes gntiques
   Lieber CS, 2004, ALCOHOL, V34, P9, DOI 10.1016/j.alcohol.2004.07.008
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Magalhaes PV, 2012, ACTA PSYCHIAT SCAND, V125, P303, DOI 10.1111/j.1600-0447.2011.01794.x
   Matza LS, 2003, ARCH GEN PSYCHIAT, V60, P817, DOI 10.1001/archpsyc.60.8.817
   McCaffery JM, 2006, PSYCHOSOM MED, V68, P187, DOI 10.1097/01.psy.0000208630.79271.a0
   McElroy SL, 2004, J CLIN PSYCHIAT, V65, P634
   McLaren L, 2008, SOC PSYCH PSYCH EPID, V43, P63, DOI 10.1007/s00127-007-0269-x
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Miller GE, 2002, AM J CARDIOL, V90, P1279, DOI 10.1016/S0002-9149(02)02863-1
   Musselman DL, 1998, ARCH GEN PSYCHIAT, V55, P580, DOI 10.1001/archpsyc.55.7.580
   Mykletun A, 2008, EUR PSYCHIAT, V23, P77, DOI 10.1016/j.eurpsy.2007.10.005
   Nabi H, 2010, INT J EPIDEMIOL, V39, P1016, DOI 10.1093/ije/dyq050
   Nabi H, 2010, BIOL PSYCHIAT, V67, P378, DOI 10.1016/j.biopsych.2009.07.040
   Nicholson A, 2006, EUR HEART J, V27, P2763, DOI 10.1093/eurheartj/ehl338
   NURNBERGER JI, 1994, ARCH GEN PSYCHIAT, V51, P849, DOI 10.1001/archpsyc.1994.03950110009002
   Parker G, 2002, AM J PSYCHIAT, V159, P1470, DOI 10.1176/appi.ajp.159.9.1470
   Penninx BWJH, 2001, ARCH GEN PSYCHIAT, V58, P221, DOI 10.1001/archpsyc.58.3.221
   Pietraszek A, 2010, NUTR METAB CARDIOVAS, V20, P366, DOI 10.1016/j.numecd.2010.05.001
   Pratt LA, 1996, CIRCULATION, V94, P3123, DOI 10.1161/01.CIR.94.12.3123
   Preisig M, 1999, EUR ARCH PSY CLIN N, V249, P174, DOI 10.1007/s004060050084
   Preisig M, 2009, BMC PSYCHIATRY, V9, DOI 10.1186/1471-244X-9-9
   Rougemont-Buecking A, 2008, PSYCHIAT RES, V157, P211, DOI 10.1016/j.psychres.2006.04.022
   Rozanski A, 1999, CIRCULATION, V99, P2192, DOI 10.1161/01.CIR.99.16.2192
   Sas Institute Inc, 2008, SAS ETS R 9 2 US GUI
   Seldenrijk A, 2011, BIOL PSYCHIAT, V69, P795, DOI 10.1016/j.biopsych.2010.12.034
   Sher L, 2003, MED HYPOTHESES, V60, P702, DOI 10.1016/S0306-9877(03)00031-8
   Simon GE, 2006, ARCH GEN PSYCHIAT, V63, P824, DOI 10.1001/archpsyc.63.7.824
   Surtees PG, 2008, NEUROLOGY, V70, P788, DOI 10.1212/01.wnl.0000304109.18563.81
   Van der Kooy K, 2007, INT J GERIATR PSYCH, V22, P613, DOI 10.1002/gps.1723
   Vancampfort D, 2011, ACTA PSYCHIAT SCAND, V123, P423, DOI 10.1111/j.1600-0447.2010.01666.x
   Vogelzangs N, 2010, J CLIN PSYCHIAT, V71, P391, DOI 10.4088/JCP.08m04743blu
   Wang ZG, 2010, ALCOHOL CLIN EXP RES, V34, P471, DOI 10.1111/j.1530-0277.2009.01111.x
   WHO Consultation on Obesity, 2000, Obesity: preventing and managing the global epidemic. Report of a who consultation, V894
   Whooley MA, 2008, JAMA-J AM MED ASSOC, V300, P2379, DOI 10.1001/jama.2008.711
   Win S, 2011, HEART, V97, P500, DOI 10.1136/hrt.2010.209767
NR 62
TC 55
Z9 59
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
EI 1600-0447
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD OCT
PY 2013
VL 128
IS 4
BP 282
EP 293
DI 10.1111/acps.12057
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 224WQ
UT WOS:000324922700006
PM 23216242
DA 2025-06-11
ER

PT J
AU McCurley, JL
   Penedo, F
   Roesch, SC
   Isasi, CR
   Carnethon, M
   Sotres-Alvarez, D
   Schneiderman, N
   Gonzalez, P
   Chirinos, DA
   Camacho, A
   Teng, YP
   Gallo, LC
AF McCurley, Jessica L.
   Penedo, Frank
   Roesch, Scott C.
   Isasi, Carmen R.
   Carnethon, Mercedes
   Sotres-Alvarez, Daniela
   Schneiderman, Neil
   Gonzalez, Patricia
   Chirinos, Diana A.
   Camacho, Alvaro
   Teng, Yanping
   Gallo, Linda C.
TI Psychosocial Factors in the Relationship between Socioeconomic Status
   and Cardiometabolic Risk: the HCHS/SOL Sociocultural Ancillary Study
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Cardiovascular; Hispanic; Latino; Metabolic syndrome; Psychosocial;
   Socioeconomic status
ID CORONARY-HEART-DISEASE; RESERVE CAPACITY MODEL; MEXICAN-AMERICAN WOMEN;
   METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; HEALTH; LATINOS;
   HISPANICS/LATINOS; DISPARITIES; PREVALENCE
AB U.S. Hispanics/Latinos display a high prevalence of metabolic syndrome (MetSyn), a group of co-occurring cardiometabolic risk factors (abdominal obesity, impaired fasting glucose, dyslipidemia, elevated blood pressure) associated with higher cardiovascular disease and mortality risk. Low socioeconomic status (SES) is associated with higher risk for MetSyn in Hispanics/Latinos, and psychosocial factors may play a role in this relationship.
   This cross-sectional study examined psychosocial factors in the association of SES and MetSyn components in 4,996 Hispanic/Latino adults from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Sociocultural Ancillary Study.
   MetSyn components were measured at the baseline examination. Participants completed interviews to determine psychosocial risks (e.g., depression) and resources (e.g., social support) within 9 months of baseline (< 4 months in 72.6% of participants). Confirmatory factor analysis (CFA) and structural equation modeling (SEM) were used to identify latent constructs and examine associations.
   Participant mean age was 41.7 years (SE = 0.4) and 62.7% were female. CFA identified single latent factors for SES and psychosocial indicators, and three factors for MetSyn [blood pressure, lipids, metabolic factors]. SEMs showed that lower SES was related to MetSyn factors indirectly through higher psychosocial risk/lower resources (Y-B chi(2) (df = 420) = 4412.90, p < .05, RMSEA = .042, SRMR = .051). A statistically significant effect consistent with mediation was found from lower SES to higher metabolic risk (glucose/waist circumference) via psychosocial risk/resource variables (Mackinnon's 95% asymmetric CI = -0.13 to -0.02).
   SES is related to metabolic variables indirectly through psychosocial factors in U.S. Hispanics/Latinos of diverse ancestries.
C1 [McCurley, Jessica L.] Univ Calif San Diego, San Diego State Univ, San Diego Joint Doctoral Program Clin Psychol, San Diego, CA 92103 USA.
   [Penedo, Frank] Northwestern Univ, Dept Med Social Sci, Chicago, IL 60611 USA.
   [Roesch, Scott C.; Gallo, Linda C.] San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA.
   [Isasi, Carmen R.] Albert Einstein Coll Med, Deptartment Epidemiol & Populat Hlth, Bronx, NY 10467 USA.
   [Carnethon, Mercedes] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA.
   [Sotres-Alvarez, Daniela] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Biostat, Collaborat Studies Coordinating Ctr, Chapel Hill, NC USA.
   [Schneiderman, Neil; Chirinos, Diana A.] Univ Miami, Dept Psychol, POB 248185, Coral Gables, FL 33124 USA.
   [Gonzalez, Patricia] San Diego State Univ, Grad Sch Publ Hlth, San Diego, CA 92182 USA.
   [Camacho, Alvaro] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.
   [Camacho, Alvaro] Univ Calif San Diego, Dept Family Med & Publ Hlth, San Diego, CA 92103 USA.
   [Teng, Yanping] Univ North Carolina Chapel Hill, Gillings Sch Publ Hlth, Dept Biostat, Chapel Hill, NC USA.
   [Gallo, Linda C.] South Bay Latino Res Ctr, 450 4th Ave,Suite 304, Chula Vista, CA 91910 USA.
C3 University of California System; University of California San Diego;
   California State University System; San Diego State University;
   Northwestern University; California State University System; San Diego
   State University; Montefiore Medical Center; Albert Einstein College of
   Medicine; Yeshiva University; Northwestern University; Feinberg School
   of Medicine; University of North Carolina; University of North Carolina
   Chapel Hill; University of Miami; California State University System;
   San Diego State University; University of California System; University
   of California San Diego; University of California System; University of
   California San Diego; University of North Carolina; University of North
   Carolina Chapel Hill; University of North Carolina School of Medicine
RP Gallo, LC (corresponding author), San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA.; Gallo, LC (corresponding author), South Bay Latino Res Ctr, 450 4th Ave,Suite 304, Chula Vista, CA 91910 USA.
EM lgallo@mail.sdsu.edu
RI González, Patricia/F-3822-2016; Sotres-Alvarez, Daniela/O-9085-2016
OI Carnethon, Mercedes/0000-0001-7035-0848; Gallo, Linda
   C./0000-0002-3678-5888
FU National Heart, Lung, and Blood Institute [75, N01-HC65233, N01-HC65234,
   N01-HC65235, N01-HC65236, N01-HC65237]; NIH/NHLBI [1 RC2 HL101649]; NIH
   [5T32HL079891-06]; GloCal Health Fellowship - Fogarty International
   Center; NHLBI; University of California Global Health Institute [R25
   TW009343]
FX The Hispanic Community Health Study/Study of Latinos was supported by
   contracts from the National Heart, Lung, and Blood Institute (75) to the
   University of North Carolina (N01-HC65233), University of Miami
   (N01-HC65234), Albert Einstein College of Medicine (N01-HC65235),
   Northwestern University (N01-HC65236), and San Diego State University
   (N01-HC65237). The following Institutes/Centers/ Offices contribute to
   the HCHS/SOL through a transfer of funds to the NHLBI: National
   Institute on Minority Health and Health Disparities, National Institute
   on Deafness and Other Communication Disorders, National Institute of
   Dental and Craniofacial Research, National Institute of Diabetes and
   Digestive and Kidney Diseases, National Institute of Neurological
   Disorders and Stroke, Office of Dietary Supplements. The HCHS/SOL
   Sociocultural Ancillary Study was supported by grant 1 RC2 HL101649 from
   the NIH/NHLBI (Gallo/Penedo PIs). Author Jessica L. McCurley was
   additionally supported by an NIH T32 training grant in Cardiovascular
   Epidemiology from the NHLBI and UC San Diego (5T32HL079891-06) and a
   GloCal Health Fellowship funded by the Fogarty International Center,
   NHLBI, and the University of California Global Health Institute (R25
   TW009343).
CR Adler NE, 2010, ANN NY ACAD SCI, V1186, P5, DOI 10.1111/j.1749-6632.2009.05337.x
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   ANDRESEN EM, 1994, AM J PREV MED, V10, P77, DOI 10.1016/S0749-3797(18)30622-6
   Avendano M, 2006, STROKE, V37, P1368, DOI 10.1161/01.STR.0000221702.75002.66
   Ballantyne CM, 2008, INT J OBESITY, V32, pS21, DOI 10.1038/ijo.2008.31
   BAREFOOT JC, 1989, PSYCHOSOM MED, V51, P46, DOI 10.1097/00006842-198901000-00005
   Baumeister H, 2014, DIABETIC MED, V31, P773, DOI 10.1111/dme.12452
   Bentler PM, 2007, PERS INDIV DIFFER, V42, P825, DOI 10.1016/j.paid.2006.09.024
   Bergmann N, 2014, ENDOCR CONNECT, V3, pR55, DOI 10.1530/EC-14-0031
   Bijker R, 2015, INTERN EMERG MED
   Bild DE, 2002, AM J EPIDEMIOL, V156, P871, DOI 10.1093/aje/kwf113
   Bosma H, 1999, BRIT MED J, V319, P1469, DOI 10.1136/bmj.319.7223.1469
   Bosma H, 2005, SOC SCI MED, V60, P737, DOI 10.1016/j.socscimed.2004.06.018
   Boyle SH, 2006, PSYCHOSOM MED, V68, P844, DOI 10.1097/01.psy.0000240779.55022.ff
   Bureau USC, 2015, US CENS QUICK FACTS
   Bureau USC, 2014, NAT POP PROJ 2014
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Cohen S, 1997, JAMA-J AM MED ASSOC, V277, P1940
   Cohen Sheldon, 1985, Social support: Theory, research and applications, P73, DOI DOI 10.1007/978-94-009-5115-05
   Cole-Laramore A., 2002, AM J PREVENTIVE MED, V67, P22
   Dokken BB., 2008, Diabetes Spectr, V21, P160, DOI [DOI 10.2337/DIASPECT.21.3.160, https://doi.org/10.2337/diaspect.21.3.160]
   Everson SA, 1996, PSYCHOSOM MED, V58, P113, DOI 10.1097/00006842-199603000-00003
   Everson-Rose SA, 2005, ANNU REV PUBL HEALTH, V26, P469, DOI 10.1146/annurev.publhealth.26.021304.144542
   Ford ES, 2008, DIABETES CARE, V31, P1898, DOI 10.2337/dc08-0423
   Ford ES, 2008, DIABETES CARE, V31, P587, DOI 10.2337/dc07-1030
   Fortmann A, 2012, ANN BEHAV MED
   Gallo LC, 2005, J PERS SOC PSYCHOL, V88, P386, DOI 10.1037/0022-3514.88.2.386
   Gallo LC, 2004, COGNITIVE THER RES, V28, P669, DOI 10.1023/B:COTR.0000045571.11566.19
   Gallo LC, 2003, PSYCHOL BULL, V129, P10, DOI 10.1037//0033-2909.129.1.10
   Gallo LC, 2016, ETHNICITY DIS
   Gallo LC, 2007, ANN BEHAV MED, V34, P14, DOI 10.1007/BF02879917
   Gallo LC, 2012, PSYCHOSOM MED, V74, P535, DOI 10.1097/PSY.0b013e31824f5f6d
   Gallo LC, 2012, HEALTH PSYCHOL, V31, P334, DOI 10.1037/a0025689
   Gallo LC, 2009, CURR DIR PSYCHOL SCI, V18, P269, DOI 10.1111/j.1467-8721.2009.01650.x
   Gallo LC, 2009, PSYCHOSOM MED, V71, P756, DOI 10.1097/PSY.0b013e3181b0d2b4
   Goldman N, 2006, AM J PUBLIC HEALTH, V96, P2186, DOI 10.2105/AJPH.2005.062752
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Grundy SM., 2011, Atlas of Atherosclerosis and Metabolic Syndrome, P1, DOI DOI 10.1007/978-1-4419-5839-6_1
   Havranek EP, 2015, CIRCULATION
   Heiss G, 2014, DIABETES CARE, V37, P2391, DOI 10.2337/dc13-2505
   Hughes ME, 2004, RES AGING, V26, P655, DOI 10.1177/0164027504268574
   Jain A, 2010, AM HEART J, V159, P652, DOI 10.1016/j.ahj.2009.12.035
   Karlamangla AS, 2010, ANN EPIDEMIOL, V20, P617, DOI 10.1016/j.annepidem.2010.05.003
   Katzmarzyk PT, 2011, OBESITY, V19, P1272, DOI 10.1038/oby.2010.319
   Kavanagh A, 2010, SOC SCI MED, V71, P1150, DOI 10.1016/j.socscimed.2010.05.038
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lavange LM, 2010, ANN EPIDEMIOL, V20, P642, DOI 10.1016/j.annepidem.2010.05.006
   Llabre MM, 2015, ANN EPIDEMIOL, V25, P480, DOI 10.1016/j.annepidem.2015.02.010
   López-Jaramillo P, 2014, WORLD J DIABETES, V5, P747, DOI 10.4239/wjd.v5.i6.747
   Loucks EB, 2007, ANN EPIDEMIOL, V17, P19, DOI 10.1016/j.annepidem.2006.07.002
   MacKinnon DP, 2007, BEHAV RES METHODS, V39, P384, DOI 10.3758/BF03193007
   Matthews KA, 2008, HEALTH PSYCHOL, V27, P576, DOI 10.1037/0278-6133.27.5.576
   Matthews KA, 2011, ANNU REV PSYCHOL, V62, P501, DOI 10.1146/annurev.psych.031809.130711
   Matthews KA, 2010, ANN NY ACAD SCI, V1186, P146, DOI 10.1111/j.1749-6632.2009.05332.x
   Montez JK, 2016, J GERONTOL B-PSYCHOL
   Moos RH, 1994, MANUAL
   Muthen L.K., 2006, Mplus
   Myers HF, 2009, J BEHAV MED, V32, P9, DOI 10.1007/s10865-008-9181-4
   Non AL, 2014, AM J EPIDEMIOL, V180, P263, DOI 10.1093/aje/kwu127
   Rosenberg M., 1965, SOC ADOLESCENT SELF
   Ryff CD, 2004, PHILOS T R SOC B, V359, P1383, DOI 10.1098/rstb.2004.1521
   SCHEIER MF, 1994, J PERS SOC PSYCHOL, V67, P1063, DOI 10.1037/0022-3514.67.6.1063
   Scheier MF, 2006, J BEHAV MED, V29, P291, DOI 10.1007/s10865-005-9044-1
   Schneiderman N, 2014, DIABETES CARE, V37, P2233, DOI 10.2337/dc13-2939
   Smith SMS, 2013, BMJ OPEN RESPIR RES, V1, DOI 10.1136/bmjresp-2014-000042
   Smith TW, 2004, J PERS, V72, P1217, DOI 10.1111/j.1467-6494.2004.00296.x
   Sorlie PD, 2010, ANN EPIDEMIOL, V20, P629, DOI 10.1016/j.annepidem.2010.03.015
   Spielberger C.D., 1994, The use of psychological testing for treatment planning and outcome assessment, P292, DOI [10.1002/9780470479216.corpsy0943, DOI 10.1002/9780470479216.CORPSY0943]
   Tillin T, 2015, DIABETIC MED, V32, P226, DOI 10.1111/dme.12576
   Uchino BN, 2006, J BEHAV MED, V29, P377, DOI 10.1007/s10865-006-9056-5
   Whalley B, 2011, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD002902, 10.1002/14651858.CD002902.pub3]
   Whittaker KS, 2012, PSYCHOSOM MED, V74, P263, DOI 10.1097/PSY.0b013e31824a58ff
   Williams M.M., 2006, CLIN DIABETES, V24, P79, DOI 10.2337/diaclin.24.2.79
   Yuan KH, 2000, SOCIOL METHODOL, V30, P165, DOI 10.1111/0081-1750.00078
NR 74
TC 18
Z9 25
U1 1
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD AUG
PY 2017
VL 51
IS 4
BP 477
EP 488
DI 10.1007/s12160-016-9871-z
PG 12
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA FF1YF
UT WOS:000408694400001
PM 28130624
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Wulsin, LR
   Blom, TJ
   Durling, M
   Welge, JA
   DelBello, MP
   Adler, CM
   McNamara, RK
   Strakowski, SM
AF Wulsin, Lawson R.
   Blom, Thomas J.
   Durling, Michelle
   Welge, Jeffrey A.
   DelBello, Melissa P.
   Adler, Caleb M.
   McNamara, Robert K.
   Strakowski, Stephen M.
TI Cardiometabolic risks and omega-3 index in recent-onset bipolar I
   disorder
SO BIPOLAR DISORDERS
LA English
DT Article
DE bipolar disorder; glucose; metabolic syndrome; omega-3 fatty acids;
   triglycerides
ID POLYUNSATURATED FATTY-ACIDS; MAJOR DEPRESSIVE DISORDER;
   CORONARY-HEART-DISEASE; CEREBRAL-BLOOD-FLOW; DRUG-NAIVE PATIENTS;
   C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; RATING-SCALE
AB ObjectivesMethodsThe aims of the present study were to characterize cardiometabolic risk factors in a cohort of bipolar disorder patients with limited exposure to psychotropic medications, and to evaluate their associations with mood symptoms and omega-3 polyunsaturated fatty acid (PUFA) blood levels.
   Cardiometabolic risk assessments were compared in individuals with bipolar I disorder experiencing a first manic or mixed episode or an early depressive episode (n=117) and healthy subjects (n=56). Patients were medication free at assessment and had no or limited exposure to mood-stabilizer or antipsychotic medications prior to the current admission. Associations among cardiometabolic parameters and Clinical Global ImpressionSeverity scale (CGI-S), manic (Young Mania Rating Scale [YMRS]), and depressive (Hamilton Depression Rating Scale [HDRS]) symptom ratings were evaluated within the bipolar group.
   ResultsConclusionsFollowing adjustment for demographic variables (i.e., age, gender, and parental education), significantly higher fasting triglyceride levels were observed in the bipolar group compared to the healthy group (121.7mg/dL vs 87.0mg/dL; P<.01). There were no clear trends for other metabolic indicators, including blood pressure, body mass index, and fasting glucose. Nineteen percent of the bipolar group and 6% of the healthy group met the criteria for metabolic syndrome (P=.23). The omega-3 index was lower in the bipolar group (3.4% vs 3.9%; P<.01). Within the bipolar group, no associations were found between the cardiometabolic parameters and CGI-S, YMRS, and HDRS symptom ratings.
   Recent-onset medication-free bipolar disorder is associated with higher triglyceride levels. These findings are suggestive of early metabolic dysregulation prior to long-term psychotropic medication exposure. Lower omega-3 PUFA levels in individuals with bipolar I disorder represent a potential therapeutic target for additional investigation.
C1 [Wulsin, Lawson R.; Blom, Thomas J.; Durling, Michelle; Welge, Jeffrey A.; DelBello, Melissa P.; Adler, Caleb M.; McNamara, Robert K.; Strakowski, Stephen M.] Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, Div Bipolar Disorders Res, Cincinnati, OH USA.
C3 University System of Ohio; University of Cincinnati
RP Wulsin, LR (corresponding author), Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, Cincinnati, OH 45220 USA.
EM lawson.wulsin@uc.edu
RI McNamara, Robert/J-4309-2014
OI McNamara, Robert/0000-0002-9703-8114
FU Center for Scientific Review [DK097599, P50 MH077138]
FX Center for Scientific Review, Grant/Award Number: DK097599 and P50
   MH077138
CR Albert CM, 2002, NEW ENGL J MED, V346, P1113, DOI 10.1056/NEJMoa012918
   Angst F, 2002, J AFFECT DISORDERS, V68, P167, DOI 10.1016/S0165-0327(01)00377-9
   [Anonymous], 1999, WECHSLER ABBREVIATED
   Arango C, 2014, J AM ACAD CHILD PSY, V53, P1179, DOI 10.1016/j.jaac.2014.08.009
   Backes J, 2016, LIPIDS HEALTH DIS, V15, DOI 10.1186/s12944-016-0286-4
   Baghai TC, 2011, J CLIN PSYCHIAT, V72, P1242, DOI 10.4088/JCP.09m05895blu
   Birdsill AC, 2013, OBESITY, V21, P1313, DOI 10.1002/oby.20170
   Bond DJ, 2010, J AFFECT DISORDERS, V124, P108, DOI 10.1016/j.jad.2009.10.023
   Calkin CV, 2015, BRIT J PSYCHIAT, V206, P52, DOI 10.1192/bjp.bp.114.152850
   Caniato RN, 2006, AUST NZ J PSYCHIAT, V40, P691, DOI 10.1111/j.1440-1614.2006.01869.x
   Centers for Disease Control and Prevention, CDC was a learned intermediary when Merck sold the MMRII vaccine to CDC for
   Correll CU, 2009, JAMA-J AM MED ASSOC, V302, P1765, DOI 10.1001/jama.2009.1549
   Davison KM, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-10
   DUKE PM, 1980, PEDIATRICS, V66, P918
   Egeland JA, 2000, J AM ACAD CHILD PSY, V39, P1245, DOI 10.1097/00004583-200010000-00011
   Evans SJ, 2014, J PSYCHIATR RES, V57, P58, DOI 10.1016/j.jpsychires.2014.06.001
   Fagiolini A, 2003, AM J PSYCHIAT, V160, P112, DOI 10.1176/appi.ajp.160.1.112
   Farzaneh-Far R, 2009, ATHEROSCLEROSIS, V205, P538, DOI 10.1016/j.atherosclerosis.2008.12.013
   Fetter Jeffrey Charles, 2013, Clin Schizophr Relat Psychoses, V7, P73, DOI 10.3371/CSRP.FEBR.012513
   First M.B., 2016, Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version
   Flock MR, 2013, J AM HEART ASSOC, V2, DOI 10.1161/JAHA.113.000513
   Freeman MP, 2015, ANN CLIN PSYCHIATRY, V27, P197
   Goldstein BI, 2016, J AM ACAD CHILD PSY, V55, P1020, DOI 10.1016/j.jaac.2016.08.010
   Goldstein BI, 2015, CIRCULATION, V132, P965, DOI 10.1161/CIR.0000000000000229
   Goldstein BI, 2015, J CLIN PSYCHIAT, V76, P163, DOI 10.4088/JCP.14m09300
   Goldstein BI, 2009, BIPOLAR DISORD, V11, P657, DOI 10.1111/j.1399-5618.2009.00735.x
   Guy W, 1976, ECDEU ASSESSMENT MAN, P219
   Hajek T, 2014, NEUROPSYCHOPHARMACOL, V39, P2910, DOI 10.1038/npp.2014.148
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Harris WS, 2017, ATHEROSCLEROSIS, V262, P51, DOI 10.1016/j.atherosclerosis.2017.05.007
   Harris WS, 2013, PROSTAG LEUKOTR ESS, V88, P257, DOI 10.1016/j.plefa.2012.12.004
   Harris WS, 2004, PREV MED, V39, P212, DOI 10.1016/j.ypmed.2004.02.030
   Hinnouho GM, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0174678
   Jacka FN, 2011, J AFFECT DISORDERS, V129, P332, DOI 10.1016/j.jad.2010.09.004
   Jennings JR, 2013, STROKE, V44, P2480, DOI 10.1161/STROKEAHA.113.001716
   Jensen KG, 2017, J CLIN PSYCHIAT, V78, pE1035, DOI 10.4088/JCP.15m10479
   Kemp DE, 2010, BIPOLAR DISORD, V12, P404, DOI 10.1111/j.1399-5618.2010.00823.x
   Leslie MA, 2015, LIPIDS HEALTH DIS, V14, DOI 10.1186/s12944-015-0049-7
   Li KL, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0088103
   Maina G, 2008, J AFFECT DISORDERS, V110, P149, DOI 10.1016/j.jad.2007.12.233
   Martin K, 2016, J AFFECT DISORDERS, V195, P88, DOI 10.1016/j.jad.2016.02.030
   McElroy SL, 2016, J AFFECT DISORDERS, V191, P216, DOI 10.1016/j.jad.2015.11.010
   McElroy SL, 2014, J CLIN PSYCHIAT, V75, P46, DOI [10.4088/JCP.13010tx4c, 10.4088/JCP.13r08634]
   McKnight RF, 2012, LANCET, V379, P721, DOI 10.1016/S0140-6736(11)61516-X
   McNamara RK, 2016, BIPOLAR DISORD, V18, P300, DOI 10.1111/bdi.12386
   McNamara RK, 2010, J AFFECT DISORDERS, V126, P303, DOI 10.1016/j.jad.2010.03.015
   Naiberg MR, 2016, ACTA PSYCHIAT SCAND, V134, P241, DOI 10.1111/acps.12603
   Ösby U, 2001, ARCH GEN PSYCHIAT, V58, P844, DOI 10.1001/archpsyc.58.9.844
   Reinders I, 2012, EUR J CLIN NUTR, V66, P736, DOI 10.1038/ejcn.2011.195
   Sands SA, 2005, LIPIDS, V40, P343, DOI 10.1007/s11745-006-1392-2
   Skjelstad DV, 2010, J AFFECT DISORDERS, V126, P1, DOI 10.1016/j.jad.2009.10.003
   Vancampfort D, 2017, WORLD PSYCHIATRY, V16, P308, DOI 10.1002/wps.20458
   Vancampfort D, 2013, AM J PSYCHIAT, V170, P265, DOI 10.1176/appi.ajp.2012.12050620
   Wersching H, 2010, NEUROLOGY, V74, P1022, DOI 10.1212/WNL.0b013e3181d7b45b
   YOUNG RC, 1978, BRIT J PSYCHIAT, V133, P429, DOI 10.1192/bjp.133.5.429
NR 55
TC 10
Z9 11
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1398-5647
EI 1399-5618
J9 BIPOLAR DISORD
JI Bipolar Disord.
PD NOV
PY 2018
VL 20
IS 7
BP 658
EP 665
DI 10.1111/bdi.12633
PG 8
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA GY8AW
UT WOS:000448841100010
PM 29479787
DA 2025-06-11
ER

PT J
AU Pelluri, R
   Kongara, S
   Chimakurthy, J
   Mahadevan, S
   Nagasubramanian, V
AF Pelluri, Ranakishor
   Kongara, Srikanth
   Chimakurthy, Jithendra
   Mahadevan, Shriraam
   Nagasubramanian, Vanitharani
TI The role of body mass index or metabolic syndrome components causing
   depression in women: An observation from weight reduction clinical trial
SO JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
LA English
DT Article
DE body mass index; insulin resistance; metabolic syndrome; PHQ-9 scale
ID HOMEOSTASIS MODEL ASSESSMENT; INSULIN-RESISTANCE; ASSOCIATION; OBESITY;
   ANXIETY
AB What is known and objective Depression is most important psychological problem that is much prevalent in women than men. Obesity and depression are the leading causes of both physical and mental disability and the link between these disorders had not explored well. The present study evaluated the link between the depression, Body mass index (BMI) and the components of metabolic syndrome (MetS) in subjects with, without insulin resistance. Methods A total of 150 subjects, vital and biochemical parameters were measured for eligible screened subjects in the trial of weight loss intervention at first visit. A self-reported Patient Health Questionnaire (PHQ-9) scale was used to assess the depression among the participants. The association of BMI and MetS components with risk of depression was analysed using multiple logistic regression analysis in subjects with and without insulin resistance. Results Obesity was associated with highly significant increase in risk of depression (OR = 13.01, 95% CI 4.40-38.49) as compared to overweight subjects. Female subjects with obesity had a greater risk for depression (beta: 3.725, OR: 42.62, 95% CI: 5.74-316.3 and p < 0.0001) than male subjects (beta: 1.922, OR: 6.83, 95% CI: 1.8-26 and p = 0.005), and it was statistically significant. There was no association between other models (IR and MetS) and depression in both genders (p < 0.05). What is new and conclusion The odds of depression was 42.62 times more in obese women and 6.83 time more in obese men compared to overweight subjects. Subjects those who are having >= 3 metabolic syndrome (MetS) components, increased the risk of depression by 0.75 times in women and 1.50 times in men. In view of these results of our study, we conclude that the body mass index is an individual strong predictor of depression whereas metabolic syndrome and insulin resistance had no significant association with depression.
C1 [Pelluri, Ranakishor] Vignan Pharm Coll, Dept Pharm Practice, Guntur 522213, Andhra Pradesh, India.
   [Pelluri, Ranakishor; Kongara, Srikanth] Endo Life Special Hosp, Dept Endocrinol & Metab, Guntur, Andhra Pradesh, India.
   [Pelluri, Ranakishor; Mahadevan, Shriraam] Sri Ramachandra Inst Higher Educ & Res Deemed Uni, Dept Pharm Practice, Chennai, Tamil Nadu, India.
   [Chimakurthy, Jithendra] Vignans Fdn Sci Technol & Res Deemed Univ, Dept Pharmaceut Sci, Guntur 522213, Andhra Pradesh, India.
   [Mahadevan, Shriraam; Nagasubramanian, Vanitharani] Sri Ramachandra Inst Higher Educ & Res Deemed Uni, Sri Ramachandra Med Coll & Res Inst, Dept Endocrinol & Metab, Chennai, Tamil Nadu, India.
C3 Sri Ramachandra Institute of Higher Education & Research; Vignan's
   Foundation for Science, Technology & Research (VFSTR); Sri Ramachandra
   Institute of Higher Education & Research
RP Nagasubramanian, V (corresponding author), Sri Ramachandra Inst Higher Educ & Res Deemed Uni, Dept Pharm Practice, Chennai, Tamil Nadu, India.
EM vanitharani.n@sriramachandra.edu.in
RI Mahadevan, Shriraam/AAP-3706-2020; Chimakurthy, Jithendra/AAZ-2859-2020;
   Nagasubramanian, Vanitha Rani/ABD-2871-2021; Pelluri M.Pharm, Ph.D, Dr.
   Ranakishor/AGA-5904-2022
OI Pelluri M.Pharm, Ph.D, Dr. Ranakishor/0000-0002-0478-4848; Mahadevan,
   Shriraam/0000-0002-6915-5639; JITHENDRA,
   CHIMAKURTHY/0000-0002-2948-4948; Kongara, Dr.
   Srikanth/0000-0002-9291-6096; NAGASUBRAMANIAN, VANITHA
   RANI/0000-0001-8390-4870
CR Agarwal A, 2016, INDIAN J PSYCHIAT, V58, P281, DOI 10.4103/0019-5545.192021
   [Anonymous], 2007, National Family Health Survey (NFHS-3) 2005-06. India, P540
   [Anonymous], 2017, Weight bias and obesity stigma: considerations for the WHO european region
   Assari S, 2015, J RACIAL ETHN HEALTH, V2, P481, DOI 10.1007/s40615-015-0096-9
   Assari S, 2014, INT CARDIOVASC RES J, V8, P44
   Aydin E, 2014, REV BRAS CIR CARDIOV, V29, P360, DOI 10.5935/1678-9741.20140105
   Calori G, 2011, DIABETES CARE, V34, P210, DOI 10.2337/dc10-0665
   Cho SJ, 2019, J AFFECT DISORDERS, V244, P54, DOI 10.1016/j.jad.2018.09.046
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Khan QU, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.6577
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Liaw FY, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/586251
   Liu JH, 2020, DIABETOL METAB SYNDR, V12, DOI 10.1186/s13098-020-00526-2
   Malik Javid Ahmad, 2017, Indian J Endocrinol Metab, V21, P106, DOI 10.4103/2230-8210.196005
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Maurer DM, 2012, AM FAM PHYSICIAN, V85, P139
   Nease DE, 2003, J FAM PRACTICE, V52, P118
   Nolen-Hoeksema S, 2002, HANDBOOK OF DEPRESSION, P492
   Ohmori Y, 2017, ASIA PAC J CLIN NUTR, V26, P130, DOI 10.6133/apjcn.112015.01
   Ortiz MS, 2018, REV MED CHILE, V146, P1278, DOI 10.4067/S0034-98872018001101278
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Perry BI, 2020, PSYCHOL MED, V50, P556, DOI 10.1017/S0033291719000308
   Segoviano-Mendoza M, 2018, BMC PSYCHIATRY, V18, DOI 10.1186/s12888-018-1596-z
   Sekita A, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-862
   Seo Y, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18010063
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
NR 26
TC 4
Z9 4
U1 1
U2 5
PU WILEY-HINDAWI
PI LONDON
PA ADAM HOUSE, 3RD FL, 1 FITZROY SQ, LONDON, WIT 5HE, ENGLAND
SN 0269-4727
EI 1365-2710
J9 J CLIN PHARM THER
JI J. Clin. Pharm. Ther.
PD DEC
PY 2021
VL 46
IS 6
BP 1757
EP 1763
DI 10.1111/jcpt.13522
EA SEP 2021
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA WW8MK
UT WOS:000693887600001
PM 34490636
OA gold
DA 2025-06-11
ER

PT J
AU AlKhathami, AD
   Alamin, MA
   Alqahtani, AM
   Alsaeed, WY
   AlKhathami, MA
   Al-Dhafeeri, AH
AF AlKhathami, Abdullah D.
   Alamin, Mohamed A.
   Alqahtani, Areej M.
   Alsaeed, Wafaa Y.
   AlKhathami, Mohammed A.
   Al-Dhafeeri, Abdulazeez H.
TI Depression and anxiety among hypertensive and diabetic primary health
   care patients Could patients' perception of their diseases
   control be used as a screening tool?
SO SAUDI MEDICAL JOURNAL
LA English
DT Article
ID METABOLIC SYNDROME; PREVALENCE; ASSOCIATION; OUTPATIENTS; SEVERITY;
   SYMPTOMS
AB Objectives: To measure the frequency and identify risk factors of depression and anxiety among diabetic and hypertensive primary health care (PHC) patients. Also to assess whether patients' perception of their chronic diseases control and sleep disturbance could serve as screening tools for depression and anxiety.
   Methods: This cross-sectional study of 368 PHC patients was conducted in AlKhobar city, Kingdom of Saudi Arabia between April and May 2015. Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7 were used as diagnostic tools for depression and anxiety.
   Results: Frequencies, cross-tabulations and logistic regression tests were performed. Patient's perception of chronic diseases control was significantly associated with the presence of depression and anxiety, while it was not seen in the tested disease control (glycated hemoglobin <7% and blood pressure <140/90 mm Hg). Sleep disturbance has a high specificity (98.9%) in screening for depression. Overall prevalence of depression or anxiety was 57.3% and detected cases was 23%. Depression comprise 48.7% (39.8% mild, 7.1% moderate, 1.8% severe). Anxiety comprise 38.4% (25.1% mild, 8.8% moderate, 4.4% severe). Co-existence of both disorders was 29.5%. Sleep disturbance, weight change, and low income had an independent significant effect on depression and anxiety.
   Conclusion: Having no sleep disturbance can rule out 98.9% of depression and anxiety cases. Patient's feelings should be considered in chronic diseases health care plans. Depression or anxiety among diabetic and hypertensive patients have a high morbidity, but with low detection rate.
C1 [AlKhathami, Abdullah D.; Alamin, Mohamed A.; Alqahtani, Areej M.] Minist Hlth, Saudi Post Grad Family Med Program, Al Khobar, Eastern Provinc, Saudi Arabia.
   [Alsaeed, Wafaa Y.] AlKhobar Hlth Ctr Adm, Al Khobar, Eastern Provinc, Saudi Arabia.
   [AlKhathami, Mohammed A.; Al-Dhafeeri, Abdulazeez H.] Minist Hlth, Al Khobar, Eastern Provinc, Saudi Arabia.
C3 Ministry of Health - Saudi Arabia; Ministry of Health - Saudi Arabia
RP Alamin, MA (corresponding author), Minist Hlth, Saudi Post Grad Family Med Program, Eastern Alkhobar, Saudi Arabia.
EM mohamedali.alamin@gmail.com
RI Abdelhamid, Mohamed/JTS-4149-2023
CR Adamis D, 2000, INT J GERIATR PSYCH, V15, P248, DOI 10.1002/(SICI)1099-1166(200003)15:3<248::AID-GPS102>3.0.CO;2-L
   Al-Hazzaa H M, 2004, East Mediterr Health J, V10, P663
   Al-Khathami AD., 2013, Mental Health in Family Medicine, V10, P203
   Al-Lugmani EB, 2014, INT J MAT SCI, V1, P469
   Al-Nozha MM, 2005, SAUDI MED J, V26, P1918
   Al-Qadhi W, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/1471-244X-14-190
   [Anonymous], Integrating mental health into primary care: A Global perspective
   Bahijri SM, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0152559
   Bcheraoui C. E., 2014, INT J HYPERTENS, V2014
   Collins MM, 2009, DIABETIC MED, V26, P153, DOI 10.1111/j.1464-5491.2008.02648.x
   DeJean D, 2013, Ont Health Technol Assess Ser, V13, P1
   Dekker RL, 2009, AM J CRIT CARE, V18, P310, DOI 10.4037/ajcc2009672
   El Bcheraoui C, 2014, INT J HYPERTENS, V2014, DOI 10.1155/2014/564679
   El Mahalli AA, 2015, INT J HEALTH SCI-IJH, V9, P119
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Habtewold TD, 2015, AUSTIN J ENDOCRINOL, V2, pid1032
   Kaur G, 2013, BMC FAM PRACT, V14, DOI 10.1186/1471-2296-14-69
   Keita GP, 2007, J MANAGE CARE PHARM, V13, pS12
   Khuwaja A. K., 2004, JPMA Journal of the Pakistan Medical Association, V54, P45
   Khuwaja AK, 2010, DIABETOL METAB SYNDR, V2, DOI 10.1186/1758-5996-2-72
   Koyanagi A, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0138261
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Milne BJ, 2009, ARCH GEN PSYCHIAT, V66, P738, DOI 10.1001/archgenpsychiatry.2009.55
   Mokdad AH, 2015, J DIABETES METAB, V6, DOI 10.4172/2155-6156.1000575
   Roglic G, 2016, Global report on psoriasis
   Roupa Z., 2009, Heal Sci J, V3, P32
   Russ TC, 2012, BMJ-BRIT MED J, V345, DOI 10.1136/bmj.e4933
   SKINNER EA, 1990, J EDUC PSYCHOL, V82, P22, DOI 10.1037/0022-0663.82.1.22
   Spitzer RL, 2006, ARCH INTERN MED, V166, P1092, DOI 10.1001/archinte.166.10.1092
   Ströhle A, 2009, J NEURAL TRANSM, V116, P777, DOI 10.1007/s00702-008-0092-x
   Suastika K, 2012, GLUCOSE TOLER, P67
   Taneja N., 2015, Telangana J Psychiatry, V1, P27
   Zarate CT, 2012, PLOS ONE, V7
   Zelman DC, 2006, CLIN J PAIN, V22, P681, DOI 10.1097/01.ajp.0000210910.49923.09
   Zhao W, 2006, PUBLIC HEALTH, V120, P696, DOI 10.1016/j.puhe.2006.04.012
   Zielazny P, PSYCHIAT POL, V24, P76
NR 36
TC 41
Z9 47
U1 0
U2 4
PU SAUDI MED J
PI RIYADH
PA ARMED FORCES HOSPITAL, PO BOX 7897,, RIYADH 11159, SAUDI ARABIA
SN 0379-5284
J9 SAUDI MED J
JI Saudi Med. J.
PD JUN
PY 2017
VL 38
IS 6
BP 621
EP 628
DI 10.15537/smj.2017.6.17941
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA EY8CX
UT WOS:000404223100008
PM 28578442
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Siervo, M
   Wells, JCK
   Cizza, G
AF Siervo, Mario
   Wells, Jonathan C. K.
   Cizza, Giovanni
TI Evolutionary theories, psychosocial stress and the modern obesity
   epidemic
SO OBESITY AND METABOLISM-MILAN
LA English
DT Review
DE human evolution; seasonality; stress response; visceral adiposity
ID BODY-MASS INDEX; ACTIVATED PROTEIN-KINASE; WORK STRESS;
   SOCIOECONOMIC-STATUS; SECULAR TRENDS; INDUSTRIAL-REVOLUTION; NUTRITION
   TRANSITION; AGONISTIC BEHAVIOR; METABOLIC SYNDROME; THRIFTY GENOTYPES
AB The thrifty genotype hypothesis of Neel theorises that a set of genes have been selected during evolution to confer an adaptive advantage. In modern times, characterized by unlimited food availability, these genes may have become metabolically harmful and may be contributing to the secular trends in weight gain and epidemic of type 2 diabetes and metabolic syndrome. These genes remain to be identified. We suggest the existence of cellular energy sensing mechanisms controlling the regulation of energy balance and we hypothesise the existence of different physiological pathways regulating anabolic or catabolic pathways. We propose that the adaptive energetic and neuro-endocrine responses that have characterized the evolution of the Homo genus exposed to uncertainty in energy supply can be explained by models of conservation of energy based upon the laws of thermodynamics. We have applied these models to modern humans to shed some light on the increased prevalence in obesity. Fluctuations in the availability of food, due to environmental and climatic perturbations, were most likely strong selective forces for the transmission of genes important for survival. However, in modern times where changes in food availability due to seasonality are attenuated, the decrease in physical activity and increase in energy intake, features of our times, are not conferring a selective advantage. Modern times are characterized by increased emotional stress and decreased sleep duration and the consequent activation of the hypothalamic-pituitary-adrenal axis, and sympatho-adrenal system which, in turn, may induce accumulation of visceral fat and metabolic syndrome. We propose that the neuroendocrine stress system evolved to enhance chances of survival for our ancestors, but in today's plentifully provisioned societies, where sedentariness and mental stress have become typical traits of modem humans, the chronic activation of the stress responses may underpin some of the metabolic characteristics of the insulin resistance syndrome.
C1 [Siervo, Mario] Elsie Widdowson Lab, MRC Human Nutr Res, Cambridge CB1 9NL, England.
   [Wells, Jonathan C. K.] Inst Child Hlth, Childrens Nutr Res Ctr, London, England.
   [Cizza, Giovanni] NIDDK, NIH, Bethesda, MD USA.
C3 UK Research & Innovation (UKRI); Medical Research Council UK (MRC); MRC
   Human Nutrition Research; University of London; University College
   London; National Institutes of Health (NIH) - USA; NIH National
   Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
RP Siervo, M (corresponding author), Elsie Widdowson Lab, MRC Human Nutr Res, Fulbourn Rd, Cambridge CB1 9NL, England.
EM Mario.Siervo@mrc-hnr.cam.ac.uk
RI Siervo, Mario/AAB-9302-2019; Wells, Jonathan/A-4604-2009
CR ADLER NE, 1994, AM PSYCHOL, V49, P15, DOI 10.1037/0003-066X.49.1.15
   Aiello LC, 2002, ANNU REV ANTHROPOL, V31, P323, DOI 10.1146/annurev.anthro.31.040402.085403
   AIELLO LC, 1995, CURR ANTHROPOL, V36, P199, DOI 10.1086/204350
   Akers KG, 2006, EUR J NEUROSCI, V24, P547, DOI 10.1111/j.1460-9568.2006.04921.x
   Al-Lawati JA, 2004, SAUDI MED J, V25, P346
   [Anonymous], 2001, DICT EPIDEMIOLOGY
   [Anonymous], 2000, HDB EMOTIONS
   [Anonymous], 2007, GLOB STRAT DIET PHYS
   [Anonymous], INT DIAB FED DIAB AT
   Atkins P., 2005, CHEM PRINCIPLES QUES, VThird
   Beck KD, 1999, BRAIN RES, V830, P56, DOI 10.1016/S0006-8993(99)01380-3
   Beilin LJ, 1997, CLIN EXP HYPERTENS, V19, P739, DOI 10.3109/10641969709083183
   BELL WJ, 1978, BEHAVIOUR, V67, P217, DOI 10.1163/156853978X00341
   Bjorntorp P, 2001, Lakartidningen, V98, P5458
   Black PH, 2003, BRAIN BEHAV IMMUN, V17, P350, DOI 10.1016/S0889-1591(03)00048-5
   Bogin B, 1996, AM J HUM BIOL, V8, P703, DOI 10.1002/(SICI)1520-6300(1996)8:6<703::AID-AJHB2>3.0.CO;2-U
   Brantley Phillip J, 2005, J La State Med Soc, V157 Spec No 1, pS19
   BRENNAN J, 1988, PRIMATES, V29, P353, DOI 10.1007/BF02380958
   Brunner EJ, 2007, AM J EPIDEMIOL, V165, P828, DOI 10.1093/aje/kwk058
   Burke JP, 2000, INT J OBESITY, V24, P1689, DOI 10.1038/sj.ijo.0801439
   Chakravarthy MV, 2004, J APPL PHYSIOL, V96, P3, DOI 10.1152/japplphysiol.00757.2003
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Charlton B G, 1997, J Health Psychol, V2, P413, DOI 10.1177/135910539700200309
   Charmandari E, 2005, ANNU REV PHYSIOL, V67, P259, DOI 10.1146/annurev.physiol.67.040403.120816
   Chrousos GP, 1998, J CLIN ENDOCR METAB, V83, P1842, DOI 10.1210/jc.83.6.1842
   Chrousos GP, 1998, ANN NY ACAD SCI, V851, P311, DOI 10.1111/j.1749-6632.1998.tb09006.x
   Chrousos GP, 2000, ENDOCR RES, V26, P513, DOI 10.3109/07435800009048562
   Cordain L, 2005, AM J CLIN NUTR, V81, P341, DOI 10.1093/ajcn.81.2.341
   COSMIDES L, 1994, COGNITION, V50, P41, DOI 10.1016/0010-0277(94)90020-5
   COSMIDES L, 1989, COGNITION, V31, P187, DOI 10.1016/0010-0277(89)90023-1
   COWAN RS, 1976, TECHNOL CULT, V17, P1, DOI 10.2307/3103251
   DARWIN C, 1892, ORIGIN SPECIES NATUR
   Du Bois D, 1989, Nutrition, V5, P303
   Duchaine B, 2001, CURR OPIN NEUROBIOL, V11, P225, DOI 10.1016/S0959-4388(00)00201-4
   EATON SB, 1990, NUTR REV, V48, P227
   Eaton SB, 2003, COMP BIOCHEM PHYS A, V136, P153, DOI 10.1016/S1095-6433(03)00208-3
   EATON SB, 1985, NEW ENGL J MED, V312, P283, DOI 10.1056/NEJM198501313120505
   Elton S, 2001, J HUM EVOL, V41, P1, DOI 10.1006/jhev.2001.0475
   Epel E, 2001, PSYCHONEUROENDOCRINO, V26, P37, DOI 10.1016/S0306-4530(00)00035-4
   ERLINGE S, 1977, Z TIERPSYCHOL, V44, P375
   Fabricatore AN, 2004, CLIN DERMATOL, V22, P332, DOI 10.1016/j.clindermatol.2004.01.006
   Filozof C, 2000, Obes Rev, V1, P21, DOI 10.1046/j.1467-789x.2000.00005.x
   Flegal KM, 1998, INT J OBESITY, V22, P39, DOI 10.1038/sj.ijo.0800541
   FOLEY RA, 1993, SOC ST HUM, V35, P17, DOI 10.1017/CBO9780511600517.003
   FOLEY RA, 1991, PHILOS T R SOC B, V334, P223, DOI 10.1098/rstb.1991.0111
   Foster MT, 2006, AM J PHYSIOL-REG I, V290, pR1284, DOI 10.1152/ajpregu.00437.2005
   Frayn K.N., 2003, METABOLIC REGULATION
   Ganong WF., 1999, REV MED PHYSL, V19th
   Gluck ME, 2004, PSYCHOSOM MED, V66, P876, DOI 10.1097/01.psy.0000143637.63508.47
   Grundy SM, 2007, J CLIN ENDOCR METAB, V92, P399, DOI 10.1210/jc.2006-0513
   HAMILTON WD, 1964, J THEOR BIOL, V7, P1, DOI [10.1016/0022-5193(64)90038-4, 10.1016/0022-5193(64)90039-6]
   Hardie DG, 2006, J PHYSIOL-LONDON, V574, P7, DOI 10.1113/jphysiol.2006.108944
   HEATH AC, 1987, BEHAV GENET, V17, P9, DOI 10.1007/BF01066007
   Hebebrand J, 2000, INT J OBESITY, V24, P345, DOI 10.1038/sj.ijo.0801135
   Hill JO, 2006, ENDOCR REV, V27, P750, DOI 10.1210/er.2006-0032
   Hill JO, 1998, SCIENCE, V280, P1371, DOI 10.1126/science.280.5368.1371
   Jacobson P, 2007, AM J EPIDEMIOL, V165, P101, DOI 10.1093/aje/kwj342
   JAMES WPT, 1984, POSTGRAD MED J, V60, P50
   Jessop TS, 2001, J ZOOL, V254, P57, DOI 10.1017/S0952836901000553
   Kac G, 1999, Cad Saude Publica, V15, P451, DOI 10.1590/S0102-311X1999000300002
   Kahn BB, 2005, CELL METAB, V1, P15, DOI 10.1016/j.cmet.2004.12.003
   Kappelman J, 1996, J HUM EVOL, V30, P243, DOI 10.1006/jhev.1996.0021
   KARASEK RA, 1979, ADMIN SCI QUART, V24, P285, DOI 10.2307/2392498
   KAWAKAMI N, 1989, IND HEALTH, V27, P149, DOI 10.2486/indhealth.27.149
   Kittel F, 2002, EUR HEART J, V23, P1841, DOI 10.1053/euhj.2002.3258
   Kivimäki M, 2006, INT J OBESITY, V30, P982, DOI 10.1038/sj.ijo.0803229
   Klein SB, 2002, PSYCHOL REV, V109, P306, DOI 10.1037//0033-295X.109.2.306
   KOMLOS J, 1990, SOC SCI HIST, V14, P69, DOI 10.2307/1171364
   Kouvonen A, 2005, PSYCHOSOM MED, V67, P577, DOI 10.1097/01.psy.0000170330.08704.62
   Kunz-Ebrecht SR, 2004, SOC SCI MED, V58, P1523, DOI 10.1016/s0277-9536(03)00347-2
   Liu Longjian, 2004, Clin Exp Pharmacol Physiol, V31 Suppl 2, pS8, DOI 10.1111/j.1440-1681.2004.04105.x
   Lopez Russell P, 2006, Environ Health, V5, P25, DOI 10.1186/1476-069X-5-25
   MARMOT MG, 1983, J PSYCHOSOM RES, V27, P377, DOI 10.1016/0022-3999(83)90069-7
   Matton L, 2007, AM J HUM BIOL, V19, P345, DOI 10.1002/ajhb.20592
   Mayorov DN, 2007, EXP PHYSIOL, V92, P471, DOI 10.1113/expphysiol.2006.036830
   McArdle W., 2000, Essentials of Exercise Physiology
   McEwen BS, 2000, NEUROPSYCHOPHARMACOL, V22, P108, DOI 10.1016/S0893-133X(99)00129-3
   McHenry HM, 2000, ANNU REV ANTHROPOL, V29, P125, DOI 10.1146/annurev.anthro.29.1.125
   MINGHELLI G, 1991, AM J CLIN NUTR, V53, P14, DOI 10.1093/ajcn/53.1.14
   Moreno LA, 2005, ARCH DIS CHILD, V90, P818, DOI 10.1136/adc.2004.067066
   NEEL JV, 1962, AM J HUM GENET, V14, P353
   Nishitani N, 2006, INT J OBESITY, V30, P528, DOI 10.1038/sj.ijo.0803153
   O'Loughlin J, 2000, INT J OBESITY, V24, P1176, DOI 10.1038/sj.ijo.0801362
   Ostry AS, 2006, BMC PUBLIC HEALTH, V6, DOI 10.1186/1471-2458-6-53
   Otten W, 1999, J VET MED A, V46, P277, DOI 10.1046/j.1439-0442.1999.00216.x
   Overgaard D, 2006, OBESITY, V14, P458, DOI 10.1038/oby.2006.60
   Patton A.R., 1962, J CHEM EDUC, V39, pA608
   Perry SF, 1999, AQUACULTURE, V177, P285, DOI 10.1016/S0044-8486(99)00092-7
   Peters A, 2004, NEUROSCI BIOBEHAV R, V28, P143, DOI 10.1016/j.neubiorev.2004.03.002
   Popkin BM, 2004, NUTR REV, V62, pS140, DOI 10.1111/j.1753-4887.2004.tb00084.x
   Popkin BM, 2004, INT J OBESITY, V28, pS2, DOI 10.1038/sj.ijo.0802557
   POSNER BM, 1995, J AM DIET ASSOC, V95, P171, DOI 10.1016/S0002-8223(95)00043-7
   Pravosudov VV, 2000, ANIM BEHAV, V60, P483, DOI 10.1006/anbe.2000.1506
   Prentice A. M., 2001, BNF Nutrition Bulletin, V26, P13, DOI 10.1046/j.1467-3010.2001.00100.x
   Prentice AM, 2005, P NUTR SOC, V64, P153, DOI 10.1079/PNS2005421
   PRENTICE AM, 1994, EUR J CLIN NUTR, V48, pS78
   Prentice AM, 2005, MECH AGEING DEV, V126, P976, DOI 10.1016/j.mad.2005.03.018
   PRENTICE AM, 1995, BRIT MED J, V311, P437, DOI 10.1136/bmj.311.7002.437
   PRENTICE AM, 1992, AM J CLIN NUTR, V56, P209, DOI 10.1093/ajcn/56.1.209S
   Prentice AM, 1997, BRIT MED BULL, V53, P229, DOI 10.1093/oxfordjournals.bmb.a011610
   RAVELLI GP, 1976, NEW ENGL J MED, V295, P349, DOI 10.1056/NEJM197608122950701
   Robert SA, 2004, SOC SCI MED, V59, P2421, DOI 10.1016/j.socscimed.2004.03.034
   ROBERTSON JD, 1952, LANCET, V262, P940
   RONA RJ, 1981, BRIT MED BULL, V37, P265, DOI 10.1093/oxfordjournals.bmb.a071713
   Roseboom T, 2006, EARLY HUM DEV, V82, P485, DOI 10.1016/j.earlhumdev.2006.07.001
   Rosengren A, 2000, J INTERN MED, V247, P111, DOI 10.1046/j.1365-2796.2000.00589.x
   Ruff CB, 1997, NATURE, V387, P173, DOI 10.1038/387173a0
   Samra JS, 1998, J CLIN ENDOCR METAB, V83, P626, DOI 10.1210/jc.83.2.626
   Sapolsky RM, 2005, SCIENCE, V308, P648, DOI 10.1126/science.1106477
   Schober E, 2007, EUR J PEDIATR, V166, P709, DOI 10.1007/s00431-006-0312-z
   Shively CA, 1997, BIOL PSYCHIAT, V41, P871, DOI 10.1016/S0006-3223(96)00185-0
   Siervo M, 2006, EUR J CLIN NUTR, V60, P455, DOI 10.1038/sj.ejcn.1602337
   Silventoinen K, 2003, J BIOSOC SCI, V35, P263, DOI 10.1017/S0021932003002633
   Solomon MB, 2007, AM J PHYSIOL-REG I, V292, pR283, DOI 10.1152/ajpregu.00330.2006
   Speakman John R, 2006, Diab Vasc Dis Res, V3, P7, DOI 10.3132/dvdr.2006.010
   Steptoe A, 1999, INT J OBESITY, V23, P1184, DOI 10.1038/sj.ijo.0801054
   Steptoe A, 2004, INT J OBESITY, V28, P1168, DOI 10.1038/sj.ijo.0802715
   Steptoe A, 2003, PSYCHOSOM MED, V65, P137, DOI 10.1097/01.PSY.0000039755.23250.A7
   STERNBERG EM, 1992, BRAIN RES, V570, P54, DOI 10.1016/0006-8993(92)90563-O
   Tamashiro KLK, 2004, PHYSIOL BEHAV, V80, P683, DOI 10.1016/j.physbeh.2003.12.002
   TANNER JM, 1992, HORM RES, V38, P106, DOI 10.1159/000182580
   Tentolouris N, 2006, ANN NY ACAD SCI, V1083, P129, DOI 10.1196/annals.1367.010
   Tooby J, 2003, PSYCHOL BULL, V129, P858, DOI 10.1037/0033-2909.129.6.858
   Ulijaszek SJ, 2002, P NUTR SOC, V61, P517, DOI 10.1079/PNS2002180
   WALSH A, 1987, INT MIGR REV, V21, P577, DOI 10.2307/2546611
   Wattigney Wendy A., 1999, Ethnicity and Disease, V9, P181
   WEBB WB, 1975, B PSYCHONOMIC SOC, V6, P47
   Wells JCK, 2006, BIOL REV, V81, P183, DOI 10.1017/S1464793105006974
   *WHO, 2007, DIAB PROGR COUNTR RE
   WHO, 2006, MED CTR OB OV
   Wood B, 1997, NATURE, V390, P120, DOI 10.1038/36450
   WOOD B, 1992, NATURE, V355, P783, DOI 10.1038/355783a0
   Wood B, 1996, BIOESSAYS, V18, P945, DOI 10.1002/bies.950181204
   WOODBURN J, 1982, MAN, V17, P431, DOI 10.2307/2801707
NR 134
TC 6
Z9 6
U1 0
U2 20
PU EDITRICE KURTIS S R L
PI MILAN
PA VIA LUIGI ZOJA 30, 20153 MILAN, ITALY
SN 1825-3865
EI 1826-7572
J9 OBES METAB-MILAN
JI Obes. Metab.-Milan
PD JUN
PY 2008
VL 4
IS 2
BP 131
EP 142
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 339HO
UT WOS:000258568900008
DA 2025-06-11
ER

PT J
AU Gurusamy, J
   Gandhi, S
   Damodharan, D
   Palaniappan, M
   Ganesan, V
AF Gurusamy, Jothimani
   Gandhi, Sailaxmi
   Damodharan, Dinakaran
   Palaniappan, Marimuthu
   Ganesan, Venkatasubramanian
TI Effect of lifestyle modification intervention (LMI) on metabolic
   syndrome in schizophrenia in a residential mental health care setting-A
   mixed method study
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
ID PEOPLE; RISK; INDIVIDUALS; FACILITATORS; BARRIERS; SUPPORT
C1 [Gurusamy, Jothimani] Natl Inst Mental Hlth & Neuro Sci NIMHANS, Coll Nursing, Bengaluru, India.
   [Gandhi, Sailaxmi] Natl Inst Mental Hlth & Neuro Sci NIMHANS, Dept Nursing, Bengaluru, India.
   [Damodharan, Dinakaran] Natl Inst Mental Hlth & Neuro Sci NIMHANS, Ctr Psychosocial Support & Disaster Management, Bangalore, India.
   [Palaniappan, Marimuthu] Natl Inst Mental Hlth & Neuro Sci NIMHANS, Dept Biostat, Bangalore, India.
   [Ganesan, Venkatasubramanian] Natl Inst Mental Hlth & Neuro Sci NIMHANS, Dept Psychiat, Bengaluru, India.
C3 National Institute of Mental Health & Neurosciences - India; National
   Institute of Mental Health & Neurosciences - India; National Institute
   of Mental Health & Neurosciences - India; National Institute of Mental
   Health & Neurosciences - India; National Institute of Mental Health &
   Neurosciences - India
RP Gurusamy, J (corresponding author), Natl Inst Mental Hlth & Neuro Sci NIMHANS, Coll Nursing, Bengaluru, India.
EM jothisrinivas.jothi@gmail.com
RI Gurusamy, Jothimani/P-6729-2019
OI Gurusamy, Jothimani/0000-0002-3844-6038
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Aschbrenner KA, 2016, PSYCHIATR REHABIL J, V39, P328, DOI 10.1037/prj0000219
   Battaglia G, 2013, NEUROPSYCH DIS TREAT, V9, P595, DOI 10.2147/NDT.S44066
   Beebe LH, 2008, PERSPECT PSYCHIATR C, V44, P25, DOI 10.1111/j.1744-6163.2008.00144.x
   Bioque M, 2018, SCHIZOPHR RES, V193, P188, DOI 10.1016/j.schres.2017.06.032
   Brütt AL, 2016, PATIENT PREFER ADHER, V10, P1881, DOI 10.2147/PPA.S108117
   Bruins J, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0112276
   Busner Joan, 2007, Psychiatry (Edgmont), V4, P28
   Corbin J., 1990, Grounded theory research: procedures, canons, and evaluative criteria, V13, P19
   Correll CU, 2015, WORLD PSYCHIATRY, V14, P119, DOI 10.1002/wps.20204
   Creswell J. W., 2011, Designing and Conducting Mixed Methods Research
   Deenik J, 2019, SCHIZOPHR RES, V204, P360, DOI 10.1016/j.schres.2018.07.033
   DINGEMANS PM, 1983, PSYCHOPHARMACOLOGY, V80, P190, DOI 10.1007/BF00427968
   Gross J, 2016, DISABIL REHABIL, V38, P123, DOI 10.3109/09638288.2015.1024343
   Guest PC, 2010, MOL PSYCHIATR, V15, P118, DOI 10.1038/mp.2009.81
   Gurusamy J, 2021, ASIAN J PSYCHIATR, V56, DOI 10.1016/j.ajp.2020.102511
   Gurusamy J, 2018, ASIAN J PSYCHIATR, V36, P73, DOI 10.1016/j.ajp.2018.06.018
   IBM Corporation, 2021, IBM SPSS Statistics for Windows. version 28.0
   Looijmans A, 2019, BMC PSYCHIATRY, V19, DOI 10.1186/s12888-019-2310-5
   McKibbin CL, 2014, COMMUNITY MENT HLT J, V50, P566, DOI 10.1007/s10597-013-9650-2
   Ratliff JC, 2013, PSYCHOSOMATICS, V54, P67, DOI 10.1016/j.psym.2012.03.001
   Rocks T, 2022, MED J AUSTRALIA, V217, pS7, DOI 10.5694/mja2.51680
   Rymaszewska J, 2012, ADV CLIN EXP MED, V21, P215
   Schröder H, 2018, INT J BEHAV NUTR PHY, V15, DOI 10.1186/s12966-018-0741-x
   Singh VK, 2023, INDIAN J PSYCHOL MED, V45, P352, DOI 10.1177/02537176231155039
   Singh VK, 2018, SCHIZOPHR RES, V202, P17, DOI 10.1016/j.schres.2018.06.066
   Tomasik J, 2019, JAMA PSYCHIAT, V76, P864, DOI 10.1001/jamapsychiatry.2019.0304
   Tsodikov F, 2022, INT J OBESITY, V46, P926, DOI 10.1038/s41366-022-01063-w
   Vancampfort D, 2019, WORLD PSYCHIATRY, V18, P53, DOI 10.1002/wps.20614
   Vancampfort D, 2015, SCHIZOPHR RES, V169, P453, DOI 10.1016/j.schres.2015.09.029
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Verhaeghe N, 2011, INT J BEHAV NUTR PHY, V8, DOI 10.1186/1479-5868-8-28
   Walburg FS, 2019, BMC PSYCHIATRY, V19, DOI 10.1186/s12888-019-2132-5
   Walker D, 2006, QUAL HEALTH RES, V16, P547, DOI 10.1177/1049732305285972
NR 34
TC 1
Z9 1
U1 2
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 2024
VL 266
BP 75
EP 84
DI 10.1016/j.schres.2024.02.002
EA FEB 2024
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA MX3R2
UT WOS:001196900900001
PM 38377870
DA 2025-06-11
ER

PT J
AU Poursalehi, D
   Shahdadian, F
   Hajhashemy, Z
   Lotfi, K
   Moradmand, Z
   Rouhani, P
   Mohammadi, S
   Mokhtari, E
   Saneei, P
AF Poursalehi, Donya
   Shahdadian, Farnaz
   Hajhashemy, Zahra
   Lotfi, Keyhan
   Moradmand, Zahra
   Rouhani, Parisa
   Mohammadi, Sobhan
   Mokhtari, Elahe
   Saneei, Parvane
TI Diet in relation to Metabolic, sleep and psychological health Status
   (DiMetS): protocol for a cross-sectional study
SO BMJ OPEN
LA English
DT Article
DE nutrition & dietetics; diabetes & endocrinology; mental health; sleep
   medicine
ID PHYSICAL-ACTIVITY QUESTIONNAIRE; PERSIAN VERSION; QUALITY INDEX;
   VALIDITY; RELIABILITY; CONSUMPTION; DISORDERS; PATTERNS; OBESITY; RISK
AB Introduction Metabolic disturbances are of major health concerns in the world. In addition to their high prevalence, these disorders have substantial roles in developing other physical and mental diseases. Diet could have a considerable influence on managing the progression of these conditions and their consequent health-related effects. The aim of the 'Diet in relation to Metabolic, sleep and psychological health Status' Project is to explore the association of nutrition with metabolic, sleep and mental health, considering potential mediators including brain-derived neurotrophic factor (BDNF) and adropin.Methods and analysis This cross-sectional study will be conducted on adults (20-65 years) working in schools of Isfahan, Iran. A multistage cluster random sampling method will be used to select participants. Anthropometric, body composition and biochemical values including fasting blood glucose, lipid profile, 25-hydroxy vitamin D, insulin, BDNF, adropin, malondialdehyde, superoxide dismutase, glutathione peroxidase, uric acid, creatinine and C reactive protein will be measured for each participant. National Cholesterol Education Program and Adult Treatment Panel III will be considered to define metabolic syndrome. Diet will be assessed through a validated Food Frequency Questionnaire. Furthermore, sleep status, mental health, quality of life, physical activity and demographic status of individuals will be assessed by validated questionnaires. The collected data will be analysed using appropriate statistical methods.Ethics and dissemination The study protocol was approved by the local Ethics Committee of Isfahan University of Medical Sciences. All participants will provide written informed consent. Dissemination will be through conference presentations and publications in peer-reviewed journals.
C1 [Poursalehi, Donya; Hajhashemy, Zahra; Saneei, Parvane] Isfahan Univ Med Sci, Esfahan, Iran.
   [Shahdadian, Farnaz] Isfahan Univ Med Sci, Dept Clin Nutr, Esfahan, Iran.
   [Lotfi, Keyhan] Univ Tehran Med Sci, Dept Community Nutr, Tehran, Iran.
   [Moradmand, Zahra; Rouhani, Parisa; Mohammadi, Sobhan; Mokhtari, Elahe] Isfahan Univ Med Sci, Dept Community Nutr, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Tehran University of Medical Sciences; Isfahan University of
   Medical Sciences
RP Saneei, P (corresponding author), Isfahan Univ Med Sci, Esfahan, Iran.
EM saneeip@yahoo.com
RI Lotfi, Keyhan/GRO-4022-2022; Shahdadian, Farnaz/ABL-3769-2022; Saneei,
   Parvane/T-5434-2019; Rouhani, Parisa/LKO-0490-2024
OI Mokhtari, Elahe/0000-0003-2368-492X; Saneei, Parvane/0000-0002-4605-7833
FU Isfahan University of Medical Sciences, Isfahan, Iran [399508]
FX The financial support for conception, design, data analysis and
   manuscript drafting comes from Isfahan University of Medical Sciences,
   Isfahan, Iran (no. 399508).
CR Ali II, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23158318
   Anjom-Shoae J, 2020, EUR J NUTR, V59, P3635, DOI 10.1007/s00394-020-02197-1
   [Anonymous], Global Health Data Exchange
   Arias D, 2022, ECLINICALMEDICINE, V54, DOI 10.1016/j.eclinm.2022.101675
   Auer M, 2018, J WOMENS HEALTH, V27, P525, DOI 10.1089/jwh.2017.6482
   Bahreinia M., 2012, Opinion: quantity and quality of carbohydrate intake in Iran: a target for nutritional intervention
   Bathina S, 2015, ARCH MED SCI, V11, P1164, DOI 10.5114/aoms.2015.56342
   Bozic J, 2018, J CLIN SLEEP MED, V14, P1109, DOI 10.5664/jcsm.7204
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1016/0165-1781(89)90047-4
   Chung F, 2008, ANESTHESIOLOGY, V108, P812, DOI 10.1097/ALN.0b013e31816d83e4
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   Esfahani FH, 2010, J EPIDEMIOL, V20, P150, DOI 10.2188/jea.JE20090083
   Furihata R, 2020, SLEEP MED, V68, P167, DOI 10.1016/j.sleep.2019.12.011
   Garmaroudi GR., 2010, Payesh (Health Monitor), V9, P137
   Ghaffarpour M, 1999, Tehran Nashre Olume Keshavarzy, V7, P42
   Godos J, 2021, SLEEP MED REV, V57, DOI 10.1016/j.smrv.2021.101430
   Harper A, 1998, PSYCHOL MED, V28, P551, DOI 10.1017/S0033291798006667
   Hidayat M., 2021, Clin Exp Psychol, V7
   Hirshkowitz M, 2015, SLEEP HEALTH, V1, P40, DOI 10.1016/j.sleh.2014.12.010
   Hu DQ, 2019, J AFFECT DISORDERS, V245, P348, DOI 10.1016/j.jad.2018.11.015
   Jabbari M, 2018, LAB MED, V49, P140, DOI 10.1093/labmed/lmx087
   Johnson DA, 2018, CURR EPIDEMIOL REP, V5, P61, DOI 10.1007/s40471-018-0139-y
   Keshteli AH, 2015, BRIT J NUTR, V113, P803, DOI 10.1017/S0007114514004140
   Kroll C, 2017, ANN HUM BIOL, V44, P667, DOI 10.1080/03014460.2017.1390153
   Kumar KG, 2008, CELL METAB, V8, P468, DOI 10.1016/j.cmet.2008.10.011
   Kumari R, 2019, DIABETES METAB SYND, V13, P2409, DOI 10.1016/j.dsx.2019.06.005
   Kuo WC, 2019, OBES REV, V20, P1651, DOI 10.1111/obr.12915
   Lian Y, 2019, PSYCHIAT RES, V274, P66, DOI 10.1016/j.psychres.2019.01.096
   Mattson MP, 2004, TRENDS NEUROSCI, V27, P589, DOI 10.1016/j.tins.2004.08.001
   Mirmiran P, 2010, PUBLIC HEALTH NUTR, V13, P654, DOI 10.1017/S1368980009991698
   Moghaddam JF, 2012, SLEEP BREATH, V16, P79, DOI 10.1007/s11325-010-0478-5
   Moghaddam M.B., 2012, WORLD APPL SCI J, V18, P1073, DOI [DOI 10.5829/idosi.wasj.2012.18.08.754, 10.5829/idosi.wasj.2012.18.08]
   Momen NC, 2020, NEW ENGL J MED, V382, P1721, DOI 10.1056/NEJMoa1915784
   Montazeri Ali, 2003, Health Qual Life Outcomes, V1, P66, DOI 10.1186/1477-7525-1-66
   Montazeri Ali, 2003, Health Qual Life Outcomes, V1, P14, DOI 10.1186/1477-7525-1-14
   Moosavian SP, 2019, ARCH IRAN MED, V22, P11
   Mozaffarian D, 2016, CIRCULATION, V133, P187, DOI 10.1161/CIRCULATIONAHA.115.018585
   Mujeic R, 2019, SOC SCI MED, V222, P346, DOI 10.1016/j.socscimed.2019.01.004
   Nejat S., 2006, J SCH PUBLIC HLTH I, V4, P1, DOI DOI 10.1007/S00038-010-0174-Z
   Noorbala AA, 2017, ARCH IRAN MED, V20, pS2
   Nucci D, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17186686
   Nutt David, 2008, Dialogues Clin Neurosci, V10, P329
   Porter GA, 2022, WORLD J PSYCHIATR, V12, P77, DOI 10.5498/wjp.v12.i1.77
   Rahafar A, 2017, CHRONOBIOL INT, V34, P273, DOI 10.1080/07420528.2016.1267187
   Ronto R, 2018, PUBLIC HEALTH NUTR, V21, P2267, DOI 10.1017/S1368980018000423
   Sadeghniiat-Haghighi K, 2015, QUAL LIFE RES, V24, P2025, DOI 10.1007/s11136-015-0923-9
   Saghafian F, 2018, BRIT J NUTR, V119, P1087, DOI 10.1017/S0007114518000697
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sandrini L, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19082281
   Saneei P, 2021, DIGEST DIS, V39, P77, DOI 10.1159/000509208
   Saneei P, 2016, EUR J NUTR, V55, P713, DOI 10.1007/s00394-015-0891-4
   Shahid A., 2011, Springer, P231, DOI [10.1007/978-1-4419-9893-4, DOI 10.1007/978-1-4419-9893-4]
   Shahjouei S, 2016, FRONT MOL BIOSCI, V3, DOI 10.3389/fmolb.2016.00025
   Shim Joohee, 2017, J Lifestyle Med, V7, P18, DOI 10.15280/jlm.2017.7.1.18
   Stansfeld S., 2016, Common mental disorders NHS Digital
   Stickley A, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-48334-7
   Tabatabaei-Malazy O, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0241926
   Vasileska A, 2012, PROCD SOC BEHV, V44, P363, DOI 10.1016/j.sbspro.2012.05.040
   Wang HH, 2020, PEDIATR GASTROENTERO, V23, P189
   Watson NF, 2015, J CLIN SLEEP MED, V11, P591, DOI 10.5664/jcsm.4758
   Willett W., 1998, Nutritional epidemiology, P302, DOI DOI 10.1093/ACPROF:OSO/9780199754038.001.0001
NR 61
TC 6
Z9 6
U1 1
U2 4
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD DEC
PY 2023
VL 13
IS 12
AR e076114
DI 10.1136/bmjopen-2023-076114
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DV8H9
UT WOS:001134943800002
PM 38110391
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cezaretto, A
   de Barros, CR
   de Almeida-Pititto, B
   Siqueira-Catania, A
   Monfort-Pires, M
   Folchetti, LGD
   Ferreira, SRG
AF Cezaretto, Adriana
   de Barros, Camila Risso
   de Almeida-Pititto, Bianca
   Siqueira-Catania, Antonela
   Monfort-Pires, Milena
   Dias Folchetti, Luciana Gavilan
   Gouvea Ferreira, Sandra Roberta
TI Lifestyle intervention using the psychoeducational approach is
   associated with greater cardiometabolic benefits and retention of
   individuals with worse health status
SO ARCHIVES OF ENDOCRINOLOGY METABOLISM
LA English
DT Article
DE Diabetes prevention; depression; lifestyle; psychoeducation; retention
ID METABOLIC SYNDROME; PHYSICAL-ACTIVITY; WEIGHT-LOSS; PREVENTION;
   SCHIZOPHRENIA; GLUCOSE; OBESITY
AB Objective: This study aimed to compare the effects of two lifestyle intervention programs for type 2 diabetes mellitus (T2DM) prevention-traditional or interdisciplinary psychoeducationbased intervention-in daily habits and cardiometabolic risk factors and investigate the role of the psychoeducational approach for the retention of individuals in the program. Subjects and methods: Between 2008 and 2010, in a public health service, 183 pre-diabetic individuals were allocated to two 18-month interventions involving diet and physical activity. Physical activity, diet, quality of life (QOL) and depression and biochemical measurements were obtained. Linear mixed-effect models were used to assess the effect of the interventions. A student t test was used to compare dropouts versus non-dropouts. Results: Improvements in energy intake and physical activity were greater in the interdisciplinary than the traditional intervention. A decrease in fat mass and blood pressure was more pronounced with interdisciplinary intervention. Dropouts from the traditional intervention only had higher BMI and lower fiber intake and QOL than non-dropouts. Conclusion: The interdisciplinary psychoeducation-based intervention revealed useful for reducing cardiometabolic risk and retaining individuals with worse health profiles. This approach represents a feasible strategy for motivating high-risk individuals to adopt a long-term healthy lifestyle.
C1 [Cezaretto, Adriana; de Barros, Camila Risso; de Almeida-Pititto, Bianca; Siqueira-Catania, Antonela; Monfort-Pires, Milena; Dias Folchetti, Luciana Gavilan; Gouvea Ferreira, Sandra Roberta] Univ Sao Paulo, Dept Epidemiol, Fac Saude Publ, Av Dr Arnaldo 715, BR-01246904 Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo
RP Ferreira, SRG (corresponding author), Univ Sao Paulo, Dept Epidemiol, Fac Saude Publ, Av Dr Arnaldo 715, BR-01246904 Sao Paulo, SP, Brazil.
EM sandrafv@usp.br
RI Ferreira, Sandra/B-9840-2012; Cezaretto, Adriana/A-4180-2015; de Almeida
   Pititto, Bianca/N-2075-2018
OI Ferreira, Sandra/0000-0002-7015-7391; de Almeida Pititto,
   Bianca/0000-0002-5907-5459; Monfort-Pires, Milena/0000-0002-1652-8083
FU Sao Paulo Research Foundation (Fapesp) [11/06376-7]; Fundacao de Amparo
   a Pesquisa do Estado de Sao Paulo (FAPESP) [11/06376-7] Funding Source:
   FAPESP
FX funding was provided by the Sao Paulo Research Foundation (Fapesp
   process number: 11/06376-7) for a student (Adriana Cezaretto) and for a
   researcher (Sandra Roberta G. Ferreira; process number: 07/55120-0).
CR Ackermann RT, 2009, OBESITY, V17, P2176, DOI 10.1038/oby.2009.114
   Adami PE, 2010, CLIN TER, V161, P537
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Almeida-Pititto B, 2010, DIABETOL METAB SYNDR, V2, DOI 10.1186/1758-5996-2-52
   ANDERSON CM, 1980, SCHIZOPHRENIA BULL, V6, P490, DOI 10.1093/schbul/6.3.490
   [Anonymous], NUTR DAT SYST RES ND
   [Anonymous], 2015, SCIENTIFICWORLDJOURN
   Au B, 2014, J PSYCHOSOM RES, V77, P180, DOI 10.1016/j.jpsychores.2014.07.012
   Bäuml J, 2006, SCHIZOPHRENIA BULL, V32, pS1, DOI 10.1093/schbul/sbl017
   BECK AT, 1988, CLIN PSYCHOL REV, V8, P77, DOI 10.1016/0272-7358(88)90050-5
   Cameron AJ, 2012, INT J OBESITY, V36, P295, DOI 10.1038/ijo.2011.103
   Cezaretto A, 2012, QUAL LIFE RES, V21, P105, DOI 10.1007/s11136-011-9919-2
   Considine RV, 1997, INT J BIOCHEM CELL B, V29, P1255, DOI 10.1016/S1357-2725(97)00050-2
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   Cuijpers P, 2009, CLIN PSYCHOL REV, V29, P449, DOI 10.1016/j.cpr.2009.04.005
   den Boer AT, 2013, NUTR METAB CARDIOVAS, V23, P1147, DOI 10.1016/j.numecd.2012.12.005
   Florez H, 2012, J GEN INTERN MED, V27, P1594, DOI 10.1007/s11606-012-2122-5
   Florindo AA, 2009, J PHYS ACT HEALTH, V6, P625, DOI 10.1123/jpah.6.5.625
   Ilanne-Parikka P, 2008, DIABETES CARE, V31, P805, DOI 10.2337/dc07-1117
   Knowler William C, 2002, N Engl J Med, V346, P393, DOI 10.1056/NEJMoa012512
   Marks R, 2005, HEALTH PROMOT PRACT, V6, P148, DOI 10.1177/1524839904266792
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Ockene IS, 2002, J AM COLL CARDIOL, V40, P630, DOI 10.1016/S0735-1097(02)02078-8
   Odenwald M, 2012, EUR ADDICT RES, V18, P54, DOI 10.1159/000333336
   Pekkarinen T, 2015, J OBES, V2015, DOI 10.1155/2015/651460
   Pibernik-Okanovic M, 2015, TRIALS, V16, DOI 10.1186/s13063-015-0833-8
   Reimers C D, 2012, J Aging Res, V2012, P243958, DOI 10.1155/2012/243958
   de Barros CR, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-136
   Saffari M, 2014, HEALTH PROMOT PERSPE, V4, P206, DOI 10.5681/hpp.2014.027
   Scott J, 2007, INT J NEUROPSYCHOPH, V10, P123, DOI 10.1017/S1461145706006900
   Sin J, 2013, J CLIN PSYCHIAT, V74, pE1145, DOI 10.4088/JCP.12r08308
   Slagter SN, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0140599
   Tuomilehto Jaakko, 2001, New England Journal of Medicine, V344, P1343, DOI 10.1056/NEJM200105033441801
   Wadden TA, 2014, JAMA-J AM MED ASSOC, V312, P1779, DOI 10.1001/jama.2014.14173
   Ware JE, 1998, J CLIN EPIDEMIOL, V51, P1167, DOI 10.1016/S0895-4356(98)00108-5
   West DS, 2007, DIABETES CARE, V30, P1081, DOI 10.2337/dc06-1966
   Young JJ, 2014, J AFFECT DISORDERS, V169, P15, DOI 10.1016/j.jad.2014.07.032
NR 37
TC 3
Z9 3
U1 1
U2 12
PU SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA
PI RIO DE JANEIRO, RJ
PA RUA HUMAITA, 85 CJ 501, RIO DE JANEIRO, RJ, 22261-000, BRAZIL
SN 2359-3997
EI 2359-4292
J9 ARCH ENDOCRIN METAB
JI Arch. Endocrinol. Metab.
PD FEB
PY 2017
VL 61
IS 1
BP 36
EP 44
DI 10.1590/2359-3997000000185
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EN1XW
UT WOS:000395804800007
PM 28273202
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Govindan, R
   Rangaswamy, T
   John, S
   Kandasamy, S
AF Govindan, Ramanujam
   Rangaswamy, Thara
   John, Sujit
   Kandasamy, Sunitha
TI Methodology for Development of a Community Level Intervention Module for
   Physical Illness in Persons with Mental Illness (CLIPMI)
SO INDIAN JOURNAL OF PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Community engagement; community mental health; community psychiatry;
   social intervention
ID METABOLIC SYNDROME; ANXIETY DISORDERS; PRIMARY-CARE; PREVALENCE; IMPACT;
   SCHIZOPHRENIA; MANAS; GOA
AB Background and Objectives:
   Medical illnesses seen in persons with psychiatric disorders are important but often ignored causes of increased morbidity and mortality. Hence, a community level intervention program addressing the issue is proposed.
   Materials and Methods:
   Patients with severe mental illnesses will be identified by a door-to-door survey and assessed for comorbid physical illnesses like anemia, hypertension, diabetes, and so on. They will then be randomized into two groups. The treatment as usual (TAU) group will not receive intervention from the trained community level workers, while the Intervention group will receive it.
   Results:
   The two groups will be compared for the prevalence and severity of comorbid physical illnesses. The expected outcome is compared to the TAU group, the intervention group will have a greater reduction in the morbidity due to physical illnesses and improved mental health.
   Conclusion:
   If successful, the module can be incorporated into the community level mental health delivery system of the District Mental Health Program (DMHP).
C1 [Govindan, Ramanujam; Kandasamy, Sunitha] Tirunelveli Med Coll, B 69,17th Cross St, Tirunelveli, Tamil Nadu, India.
   [Rangaswamy, Thara; John, Sujit] Schizophrenia Res Fdn, Chennai, Tamil Nadu, India.
RP Govindan, R (corresponding author), Tirunelveli Med Coll, B 69,17th Cross St, Tirunelveli, Tamil Nadu, India.
EM ramsych2@gmail.com
RI Rangaswamy, Thara/JXK-9468-2024
OI Rangaswamy, Thara/0000-0001-6813-066X; John, Sujit/0000-0001-7157-3533
FU 'Capacity Building Task Force for Mental Health Research in India' -
   Indian Council of Medical Research [5/4-4/151/M/2017/NCD-1]; training
   program `Cross Fertilized Research Training for New Investigators in
   India and Egypt' - FIC, NIH [D43 TW009114]
FX This protocol paper describes the methodology of a research project
   funded under 'Capacity Building Task Force for Mental Health Research in
   India' funded by the Indian Council of Medical Research vide file number
   5/4-4/151/M/2017/NCD-1. International mentors were funded by the
   training program `Cross Fertilized Research Training for New
   Investigators in India and Egypt' funded by FIC, NIH (No. D43 TW009114).
CR Andrade C, 2016, J CLIN PSYCHIAT, V77, pE964, DOI 10.4088/JCP.16f11060
   Chatterjee S, 2014, LANCET, V383, P2046
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P138
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   Ganesh S, 2016, ASIAN J PSYCHIATR, V22, P86, DOI 10.1016/j.ajp.2016.05.006
   GUY W., 1976, NATL I MENTAL HLTH P
   IBM Corp. Released, 2015, IBM SPSS STAT WINDOW
   Joshi R, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0103754
   Lakhan R, 2015, J NEUROSCI RURAL PRA, V6, P51, DOI 10.4103/0976-3147.143194
   Lawrence D, 2010, J PSYCHOPHARMACOL, V24, P61, DOI 10.1177/1359786810382058
   Math Suresh Bada, 2010, Indian J Psychiatry, V52, pS95, DOI 10.4103/0019-5545.69220
   Morgan C, 2015, SOC PSYCH PSYCH EPID, V50, P879, DOI 10.1007/s00127-015-1013-6
   National Mental Health Survey of India, 2015, PREV PATT OUTC SUPP
   Padmavati R, 2016, INDIAN J MED RES, V143, P395, DOI 10.4103/0971-5916.184280
   Patel V, 2011, BRIT J PSYCHIAT, V199, P459, DOI 10.1192/bjp.bp.111.092155
   Patel V, 2010, LANCET, V376, P2086, DOI 10.1016/S0140-6736(10)61508-5
   Riley L, 2016, AM J PUBLIC HEALTH, V106, P74, DOI 10.2105/AJPH.2015.302962
   Sheehan DV, 1998, J CLIN PSYCHIAT, V59, P22, DOI 10.4088/JCP.09m05305whi
   Shinde S, 2013, SOC SCI MED, V88, P48, DOI 10.1016/j.socscimed.2013.04.002
   WHO, 1979, Schizophrenia: An international follow-up study
NR 20
TC 2
Z9 2
U1 1
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0253-7176
EI 0975-1564
J9 INDIAN J PSYCHOL MED
JI Indian J. Psychol. Med.
PD DEC
PY 2020
VL 42
IS 6_SUPPL
SU 6_
BP S94
EP S98
DI 10.1177/0253717620973381
PG 5
WC Psychiatry; Psychology
WE Emerging Sources Citation Index (ESCI)
SC Psychiatry; Psychology
GA QA9XI
UT WOS:000613797400016
PM 33487810
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kure, C
AF Kure, Christine
TI Cognitive health
SO JOURNAL OF COMPLEMENTARY MEDICINE
LA English
DT Article
ID DOSE-DEPENDENT CHANGES; EXTRACT EGB 761(R); ALPHA-LIPOIC ACID;
   BACOPA-MONNIERA; GINKGO-BILOBA; DOUBLE-BLIND; ALZHEIMERS-DISEASE;
   STANDARDIZED EXTRACT; OXIDATIVE STRESS; CENTRAL OBESITY
AB Oxidative stress, inflammation and free-radical damage to mitochondria have been associated with neurodegenerative diseases such as Alzheimer's and Parkinson's
   Various risk factors have been associated with age-related cognitive decline, including hypertension, obesity, diabetes, metabolic syndrome, history of anxiety/depression, elevated homocysteine levels, inflammation, alcohol intake, smoking and diet
   Epidemiological, clinical and preclinical studies have shown that some traditional herbal, mind-body and nutraceutical treatments are effective in preventing age-related cognitive decline
   Limited research has been conducted on the benefits of such treatments on neurodegenerative disorders such as Parkinson's disease
C1 Swinburne Univ Technol, BSI, NICM Collaborat Ctr Neurocognit, Hawthorn, Vic 3122, Australia.
C3 Swinburne University of Technology
RP Kure, C (corresponding author), Swinburne Univ Technol, BSI, NICM Collaborat Ctr Neurocognit, Hawthorn, Vic 3122, Australia.
OI Kure, Christina/0000-0001-8328-0084
CR Akhondzadeh S, 2003, J CLIN PHARM THER, V28, P53, DOI 10.1046/j.1365-2710.2003.00463.x
   [Anonymous], COCHRANE DATABASE SY
   Bhattacharya SK, 1998, PHYTOMEDICINE, V5, P77, DOI 10.1016/S0944-7113(98)80001-9
   Bragin Valentin, 2005, Am J Alzheimers Dis Other Demen, V20, P21, DOI 10.1177/153331750502000103
   Calabrese C, 2008, J ALTERN COMPLEM MED, V14, P707, DOI 10.1089/acm.2008.0018
   Chan A, 2008, AM J ALZHEIMERS DIS, V23, P571, DOI 10.1177/1533317508325093
   Channa S, 2006, J ETHNOPHARMACOL, V104, P286, DOI 10.1016/j.jep.2005.10.009
   Choi YT, 2001, LIFE SCI, V70, P603, DOI 10.1016/S0024-3205(01)01438-2
   DeKosky ST, 2008, JAMA-J AM MED ASSOC, V300, P2253, DOI 10.1001/jama.2008.683
   Dhanasekaran M, 2009, PHYTOTHER RES, V23, P14, DOI 10.1002/ptr.2405
   Durga J, 2007, LANCET, V369, P208, DOI 10.1016/S0140-6736(07)60109-3
   Freund-Levi Y, 2006, ARCH NEUROL-CHICAGO, V63, P1402, DOI 10.1001/archneur.63.10.1402
   Gold PE, 2002, PSYCHOL SCI, P2, DOI 10.1111/1529-1006.00006
   Guo Yi, 2002, Frontiers of Medical and Biological Engineering, V11, P237, DOI 10.1163/156855701321138905
   Hager K, 2001, ARCH GERONTOL GERIAT, V32, P275, DOI 10.1016/S0167-4943(01)00104-2
   Hendrie Hugh C, 2006, Alzheimers Dement, V2, P12, DOI 10.1016/j.jalz.2005.11.004
   Heo JH, 2008, EUR J NEUROL, V15, P865, DOI 10.1111/j.1468-1331.2008.02157.x
   Holcomb LA, 2006, J ALZHEIMERS DIS, V9, P243
   Holmquist L, 2007, PHARMACOL THERAPEUT, V113, P154, DOI 10.1016/j.pharmthera.2006.07.001
   Ishrat T, 2006, BEHAV BRAIN RES, V171, P9, DOI 10.1016/j.bbr.2006.03.009
   Jagust W, 2005, ARCH NEUROL-CHICAGO, V62, P1545, DOI 10.1001/archneur.62.10.1545
   Jorm AF, 2004, INT PSYCHOGERIATR, V16, P209, DOI 10.1017/S1041610204000298
   Kalaria RN, 2008, LANCET NEUROL, V7, P812, DOI 10.1016/S1474-4422(08)70169-8
   Kalmijn S, 2004, NEUROLOGY, V62, P275, DOI 10.1212/01.WNL.0000103860.75218.A5
   Kennedy DO, 2006, CURR PHARM DESIGN, V12, P4613, DOI 10.2174/138161206779010387
   Kennedy DO, 2001, NUTR NEUROSCI, V4, P295, DOI 10.1080/1028415X.2001.11747370
   Kennedy DO, 2001, NUTR NEUROSCI, V4, P399, DOI 10.1080/1028415X.2001.11747376
   Kristofikova Z, 1997, DEMENT GERIATR COGN, V8, P43
   Kuriyama S, 2006, AM J CLIN NUTR, V83, P355
   Landin J, 2008, INT J GERIATR PSYCH, V23, P1163, DOI 10.1002/gps.2046
   Laurin D, 2001, ARCH NEUROL-CHICAGO, V58, P498, DOI 10.1001/archneur.58.3.498
   Le Bars PL, 2000, DEMENT GERIATR COGN, V11, P230, DOI 10.1159/000017242
   Liu JK, 2008, NEUROCHEM RES, V33, P194, DOI 10.1007/s11064-007-9403-0
   MAITRA I, 1995, BIOCHEM PHARMACOL, V49, P1649, DOI 10.1016/0006-2952(95)00089-I
   Malaguarnera M, 2007, AM J CLIN NUTR, V86, P1738
   Malouf R, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004514.pub2
   Mandel S, 2004, J NEUROCHEM, V88, P1555, DOI 10.1046/j.1471-4159.2003.02291.x
   Mandel S, 2003, CNS DRUGS, V17, P729, DOI 10.2165/00023210-200317100-00004
   Mariani E, 2005, J CHROMATOGR B, V827, P65, DOI 10.1016/j.jchromb.2005.04.023
   Mix JA, 2002, HUM PSYCHOPHARM CLIN, V17, P267, DOI 10.1002/hup.412
   Moore A, 2009, CONSCIOUS COGN, V18, P176, DOI 10.1016/j.concog.2008.12.008
   Morris MC, 2002, ARCH NEUROL-CHICAGO, V59, P1125, DOI 10.1001/archneur.59.7.1125
   Morris MC, 2003, ARCH NEUROL-CHICAGO, V60, P940, DOI 10.1001/archneur.60.7.940
   Nurk E, 2007, AM J CLIN NUTR, V86, P1470, DOI 10.1093/ajcn/86.5.1470
   Oken BS, 2006, ALTERN THER HEALTH M, V12, P40
   Pagnoni G, 2007, NEUROBIOL AGING, V28, P1623, DOI 10.1016/j.neurobiolaging.2007.06.008
   Pavlovic DM, 2008, SRP ARK CELOK LEK, V136, P170, DOI 10.2298/SARH0804170P
   Pipingas A, 2008, PHYTOTHER RES, V22, P1168, DOI 10.1002/ptr.2388
   Polidori M C, 2003, J Postgrad Med, V49, P229
   Rai D, 2003, PHARMACOL BIOCHEM BE, V75, P823, DOI 10.1016/S0091-3057(03)00156-4
   Riddle DR, 2007, REV CLIN GERONTOL, V17, P225, DOI 10.1017/S0959259808002530
   Roodenrys S, 2002, NEUROPSYCHOPHARMACOL, V27, P279, DOI 10.1016/S0893-133X(01)00419-5
   Russo A, 2005, PHYTOMEDICINE, V12, P305, DOI 10.1016/j.phymed.2003.12.008
   Ryan J, 2008, J PSYCHOPHARMACOL, V22, P553, DOI 10.1177/0269881108091584
   Sairam K, 2002, PHYTOMEDICINE, V9, P207, DOI 10.1078/0944-7113-00116
   Scholey A, 2008, DRUG FUTURE, V33, P869, DOI 10.1358/dof.2008.33.10.1250977
   Scholey AB, 2008, PSYCHOPHARMACOLOGY, V198, P127, DOI 10.1007/s00213-008-1101-3
   Shults CW, 2002, ARCH NEUROL-CHICAGO, V59, P1541, DOI 10.1001/archneur.59.10.1541
   Smith PF, 1996, J ETHNOPHARMACOL, V50, P131, DOI 10.1016/0378-8741(96)01379-7
   Sorensen H, 1996, CURR THER RES CLIN E, V57, P959, DOI 10.1016/S0011-393X(96)80114-7
   Stough C, 2001, PSYCHOPHARMACOLOGY, V156, P481, DOI 10.1007/s002130100815
   Stough C, 2001, INT J NEUROPSYCHOPH, V4, P131, DOI 10.1017/S1461145701002292
   Stough C, 2008, PHYTOTHER RES, V22, P1629, DOI 10.1002/ptr.2537
   Sun YX, 2003, DEMENT GERIATR COGN, V16, P136, DOI 10.1159/000071001
   Tripathi Yamini B., 1996, Indian Journal of Experimental Biology, V34, P523
   UAUY R, 2006, NUTR REV S1, V64
   van de Rest O, 2008, NEUROLOGY, V71, P430, DOI 10.1212/01.wnl.0000324268.45138.86
   Wattanathorn J, 2008, J ETHNOPHARMACOL, V116, P325, DOI 10.1016/j.jep.2007.11.038
   Weinreb O, 2007, FREE RADICAL BIO MED, V43, P546, DOI 10.1016/j.freeradbiomed.2007.05.011
   Whitmer RA, 2008, NEUROLOGY, V71, P1057, DOI 10.1212/01.wnl.0000306313.89165.ef
   Wilson RS, 2007, NEUROLOGY, V69, P1911, DOI 10.1212/01.wnl.0000271087.67782.cb
   Wilson RS, 2002, JAMA-J AM MED ASSOC, V287, P742, DOI 10.1001/jama.287.6.742
   Xu GL, 2009, PSYCHIAT CLIN NEUROS, V63, P43, DOI 10.1111/j.1440-1819.2008.01904.x
   Xue CCL, 2007, J ALTERN COMPLEM MED, V13, P643, DOI 10.1089/acm.2006.6355
   Zandi PP, 2004, ARCH NEUROL-CHICAGO, V61, P82, DOI 10.1001/archneur.61.1.82
NR 75
TC 0
Z9 0
U1 0
U2 9
PU AUSTRALIAN PHARMACEUTICAL PUBLISHING CO LTD
PI HAWTHORN
PA 40 BURWOOD ROAD, HAWTHORN, VIC 3122, AUSTRALIA
SN 1446-8263
J9 J COMPLEMENT MED
JI J. Complement. Med.
PD SEP-OCT
PY 2009
VL 8
IS 5
BP 12
EP +
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 496HO
UT WOS:000269961100015
DA 2025-06-11
ER

PT J
AU Busnatu, SS
   Serbanoiu, LI
   Lacraru, AE
   Andrei, CL
   Jercalau, CE
   Stoian, M
   Stoian, A
AF Busnatu, Stefan Sebastian
   Serbanoiu, Liviu Ionut
   Lacraru, Andreea Elena
   Andrei, Catalina Liliana
   Jercalau, Cosmina Elena
   Stoian, Marilena
   Stoian, Anca
TI Effects of Exercise in Improving Cardiometabolic Risk Factors in
   Overweight Children: A Systematic Review and Meta-Analysis
SO HEALTHCARE
LA English
DT Review
DE physical stress; cardiometabolic; risk factors; long term intervention
ID CORONARY-ARTERY-DISEASE; BODY-MASS INDEX; QUALITY-OF-LIFE; CHILDHOOD
   OBESITY; ADIPOSE-TISSUE; WEIGHT-LOSS; MENTAL-HEALTH; FAT MASS;
   INTERVENTIONS; ADOLESCENTS
AB This meta-analysis aims to evaluate the effects of exercise in improving cardiometabolic risk factors in overweight children and adolescents until the adolescent age, which is 18 years. A systemic search was conducted using the electronic databases PubMed/Medline, Cochrane Library, and Google Scholar, from inception to 29 June 2021. All statistical analyses were conducted in Review Manager 5.4.1. All studies meeting the inclusion criteria were selected. A random-effect model was used to pool the studies, and the results are reported in the odds ratio (OR) and corresponding 95% Confidence interval (CI). Twelve randomized control trials were selected for meta-analysis. Significant results were obtained for BMI in children after the interventions (0.38 95% CI 0.14, 0.62; p = 0.002; I-2 = 65%). LDL level was also found significantly reduced (0.41 95% CI 0.01, 0.82; p = 0.05; I-2 = 83%). Other factors such as HDL level, blood pressure, blood glucose level, body weight, and waist circumference were also analyzed. We found that exercise interventions significantly improved several cardiometabolic risk factors such as BMI, LDL level, BP, and blood glucose level. However, no significant effect on HDL concentration, waist circumference, and body weight were found. Long-term interventions are needed to attain improvement in all cardiometabolic risk factors.
C1 [Busnatu, Stefan Sebastian; Serbanoiu, Liviu Ionut; Lacraru, Andreea Elena; Andrei, Catalina Liliana; Jercalau, Cosmina Elena; Stoian, Marilena; Stoian, Anca] Univ Med & Pharm Carol Davila, Emergency Hosp Bagdasar Arseni, Dept Cardiol, Bucharest 050474, Romania.
   [Stoian, Anca] Carol Davila Univ Med & Pharm, Dept Diabet Nutr & Metab Dis, Bucharest 020021, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy
RP Serbanoiu, LI (corresponding author), Univ Med & Pharm Carol Davila, Emergency Hosp Bagdasar Arseni, Dept Cardiol, Bucharest 050474, Romania.
EM stefan.busnatu@umfcd.ro; liviu-ionut.serbanoiu@drd.umfcd.ro;
   andreea.lacraru@umfcd.ro; catalina.andrei@umfcd.ro;
   cosmina-elena.jercalau@rez.umfcd.ro; marinela.stoian@umfcd.ro;
   anca.stoian@umfcd.ro
RI Busnatu, Stefan/K-7025-2019; Andrei, Catalina/KHU-8658-2024; Serbanoiu,
   Liviu Ionut/GQA-8087-2022; Pantea Stoian, Anca/H-5799-2017
OI Serbanoiu, Liviu Ionut/0000-0001-5081-2478; Jercalau,
   Cosmina/0000-0003-3290-2730; Busnatu, Stefan/0000-0002-4678-9655; Pantea
   Stoian, Anca/0000-0003-0555-526X
CR Abootorabi MS, 2018, GYNECOL ENDOCRINOL, V34, P489, DOI 10.1080/09513590.2017.1418311
   An Ruopeng, 2017, Int J Adolesc Med Health, V29, DOI 10.1515/ijamh-2015-0045
   Astorino TA, 2018, EUR J APPL PHYSIOL, V118, P51, DOI 10.1007/s00421-017-3756-0
   Bass R, 2015, POSTGRAD MED J, V91, P639, DOI 10.1136/postgradmedj-2014-133033
   Bassols J, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0226303
   Batacan RB Jr, 2017, BRIT J SPORT MED, V51, DOI 10.1136/bjsports-2015-095841
   BERCHTOLD P, 1982, HYPERTENSION, V4, P50
   Booth A, 2016, HORM MOL BIOL CLIN I, V26, P25, DOI 10.1515/hmbci-2015-0073
   Bosello O, 2016, EAT WEIGHT DISORD-ST, V21, P165, DOI 10.1007/s40519-016-0278-4
   Brady EM, 2018, DIABETES RES CLIN PR, V139, P195, DOI 10.1016/j.diabres.2018.03.010
   Brand C, 2020, J SPORT SCI, V38, P682, DOI 10.1080/02640414.2020.1725384
   Catalano PM, 2017, BMJ-BRIT MED J, V356, DOI 10.1136/bmj.j1
   Cumpston M, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.ED000142
   Dalrymple KV, 2020, PEDIATR OBES, V15, DOI 10.1111/ijpo.12608
   Dascalu AM, 2021, J CLIN MED, V10, DOI 10.3390/jcm10163736
   Dias KA, 2018, SPORTS MED, V48, P733, DOI 10.1007/s40279-017-0777-0
   Díaz M, 2015, PEDIATR DIABETES, V16, P538, DOI 10.1111/pedi.12220
   Fang XQ, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000016825
   Frank A, 1998, J AM DIET ASSOC, V98, pS44, DOI 10.1016/S0002-8223(98)00710-X
   García-Hermoso A, 2016, OBES REV, V17, P531, DOI 10.1111/obr.12395
   Gomes F, 2010, ARQ BRAS CARDIOL, V94, P273, DOI 10.1590/S0066-782X2010000200021
   Goossens GH, 2017, OBESITY FACTS, V10, P207, DOI 10.1159/000471488
   Gurnani M, 2015, PEDIATR CLIN N AM, V62, P821, DOI 10.1016/j.pcl.2015.04.001
   Gutin I, 2018, SOC THEOR HEALTH, V16, P256, DOI 10.1057/s41285-017-0055-0
   Halfon N, 2013, ACAD PEDIATR, V13, P6, DOI 10.1016/j.acap.2012.10.007
   Haluzik M, 2010, Vnitr Lek, V56, P1028
   Hartley A, 2019, TRENDS CARDIOVAS MED, V29, P22, DOI 10.1016/j.tcm.2018.05.010
   Hemmingsson E, 2018, CURR OBES REP, V7, P204, DOI 10.1007/s13679-018-0310-2
   Ho M, 2012, PEDIATRICS, V130, pE1647, DOI 10.1542/peds.2012-1176
   Hobkirk JP, 2012, METAB SYNDR RELAT D, V10, P20, DOI 10.1089/met.2011.0050
   Huang IC, 2006, INT J OBESITY, V30, P1250, DOI 10.1038/sj.ijo.0803250
   Hutton B, 2015, ANN INTERN MED, V162, P777, DOI 10.7326/M14-2385
   Ibrahim MM, 2010, OBES REV, V11, P11, DOI 10.1111/j.1467-789X.2009.00623.x
   Kamal NN, 2012, DIABETOL METAB SYNDR, V4, DOI 10.1186/1758-5996-4-27
   Kelsey MM, 2014, GERONTOLOGY, V60, P222, DOI 10.1159/000356023
   Khosravi M, 2018, HORM MOL BIOL CLIN I, V35, DOI 10.1515/hmbci-2018-0024
   Kostovski Marko, 2017, Pril (Makedon Akad Nauk Umet Odd Med Nauki), V38, P121, DOI 10.2478/prilozi-2018-0013
   Li ZY, 2011, CLIN EXP PHARMACOL P, V38, P888, DOI 10.1111/j.1440-1681.2011.05602.x
   Llewellyn A, 2016, OBES REV, V17, P56, DOI 10.1111/obr.12316
   Luo YT, 2017, CELL RES, V27, P352, DOI 10.1038/cr.2017.8
   Macknin M, 2015, J PEDIATR-US, V166, P953, DOI 10.1016/j.jpeds.2014.12.058
   Branco BHM, 2020, J STRENGTH COND RES, V34, P2672, DOI 10.1519/JSC.0000000000002877
   Martin-Smith R, 2019, PEDIATR EXERC SCI, V31, P296, DOI 10.1123/pes.2018-0155
   Meijer RI, 2011, CURR DIABETES REP, V11, P211, DOI 10.1007/s11892-011-0186-y
   Meng L X, 2019, Zhonghua Liu Xing Bing Xue Za Zhi, V40, P839, DOI 10.3760/cma.j.issn.0254-6450.2019.07.019
   Naito R, 2017, INT HEART J, V58, P475, DOI 10.1536/ihj.17-191
   Nathan BM, 2008, CURR OPIN ENDOCRINOL, V15, P21, DOI 10.1097/MED.0b013e3282f43d19
   Neeland IJ, 2018, CIRCULATION, V137, P1391, DOI 10.1161/CIRCULATIONAHA.117.029617
   Nielsen LA, 2015, OBESITY FACTS, V8, P319, DOI 10.1159/000441375
   O'Rourke RW, 2018, SURG OBES RELAT DIS, V14, P1755, DOI 10.1016/j.soard.2018.07.032
   Office of World Health Reporting, 2002, WORLD HLTH REPORT 20
   Paahoo A, 2020, IRAN J PEDIATR, V30, DOI 10.5812/ijp.99760
   Partsalaki I, 2012, J PEDIATR ENDOCR MET, V25, P697, DOI 10.1515/jpem-2012-0131
   Pelletier JE, 2016, HEALTH EDUC BEHAV, V43, P139, DOI 10.1177/1090198115598983
   Pozuelo-Carrascosa DP, 2018, PEDIATRICS, V142, DOI 10.1542/peds.2018-1033
   Rajakumar K, 2020, AM J CLIN NUTR, V111, P757, DOI 10.1093/ajcn/nqz340
   Rajjo T, 2017, J CLIN ENDOCR METAB, V102, P758, DOI 10.1210/jc.2016-2575
   Rosqvist F, 2014, DIABETES, V63, P2356, DOI 10.2337/db13-1622
   Ross LM, 2016, J SPORT HEALTH SCI, V5, P139, DOI 10.1016/j.jshs.2016.04.005
   Sabin MA, 2015, J PAEDIATR CHILD H, V51, P82, DOI 10.1111/jpc.12819
   Seabra A, 2020, PROG CARDIOVASC DIS, V63, P807, DOI 10.1016/j.pcad.2020.07.007
   Seo YG, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010137
   Shalitin S, 2009, HORM RES, V72, P287, DOI 10.1159/000245931
   Sigal RJ, 2014, JAMA PEDIATR, V168, P1006, DOI 10.1001/jamapediatrics.2014.1392
   Skrede T, 2019, OBES REV, V20, P55, DOI 10.1111/obr.12758
   Small L, 2016, CHILD ADOL PSYCH CL, V25, P269, DOI 10.1016/j.chc.2015.11.008
   Smitka Kvido, 2015, Prague Med Rep, V116, P87, DOI 10.14712/23362936.2015.49
   Solmi M, 2019, EUR J CLIN INVEST, V49, DOI 10.1111/eci.13080
   Specht IO, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0200388
   Stadler JT, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21238985
   Stoner L, 2016, SPORTS MED, V46, P1737, DOI 10.1007/s40279-016-0537-6
   Suceveanu AI, 2020, METABOLITES, V10, DOI 10.3390/metabo10110448
   Swallen KC, 2005, PEDIATRICS, V115, P340, DOI 10.1542/peds.2004-0678
   Taylor BJ, 2017, PEDIATRICS, V139, DOI 10.1542/peds.2016-2037
   Thivel D, 2019, J SPORT MED PHYS FIT, V59, P310, DOI [10.23736/S0022-4707.18.08075-1, 10.23736/s0022-4707.18.08075-1]
   Trinh A, 2013, PEDIATRICS, V131, pE470, DOI 10.1542/peds.2012-1092
   Tyson N, 2018, BEST PRACT RES CL OB, V48, P158, DOI 10.1016/j.bpobgyn.2017.06.003
   van Biljon A, 2018, J PEDIATR-US, V203, P325, DOI 10.1016/j.jpeds.2018.07.067
   Weihrauch-Blüher S, 2019, METABOLISM, V92, P147, DOI 10.1016/j.metabol.2018.12.001
   Weihrauch-Blüher S, 2018, CURR OBES REP, V7, P254, DOI 10.1007/s13679-018-0320-0
   Welbourn R, 2016, OBES SURG, V26, P649, DOI 10.1007/s11695-015-2041-8
   Whitlock EP, 2005, PEDIATRICS, V116, pE125, DOI 10.1542/peds.2005-0242
   Williams AS, 2018, J AM BOARD FAM MED, V31, P514, DOI 10.3122/jabfm.2018.04.170261
NR 83
TC 13
Z9 13
U1 3
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD JAN
PY 2022
VL 10
IS 1
AR 82
DI 10.3390/healthcare10010082
PG 17
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA YN9XZ
UT WOS:000747604800001
PM 35052246
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Roohafza, H
   Sadeghi, M
   Talaei, M
   Pourmoghaddas, Z
   Sarrafzadegan, N
AF Roohafza, Hamidreza
   Sadeghi, Masoumeh
   Talaei, Mohammad
   Pourmoghaddas, Zahra
   Sarrafzadegan, Nizal
TI Psychological Status and Quality of Life in relation to the Metabolic
   Syndrome: Isfahan Cohort Study
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID DEPRESSIVE SYMPTOMS; YOUNG-ADULTS; HEALTH; WOMEN; POPULATION;
   PREVALENCE; ANXIETY; RISK
AB Objective. Current study was designed to investigate the association of metabolic syndrome (MetS) with depression, anxiety, psychological distress, and quality of life (QoL). Design. Two hundred and fifteen contributors with MetS and 253 participants without MetS were randomly selected from 2151 participants of Isfahan Cohort Study who were residents of Isfahan city. Measurements consisted of fasting blood samples, anthropometrics, and self-reported data of 12-item General Health Questionnaire, Hospital Anxiety and Depression Scale, and European Quality of Life-5 Dimension. Binary logistic regression analysis was used to find the association between MetS and four psychological factors. Results. Participants mean age was 56.3 +/- 9.8 years. Male/female ratio was 0.86 (217/251). Mean score of depression (P = 0.003), anxiety (P = 0.018), distress (P = 0.047), and QoL (P <= 0.001) was significantly higher in MetS group. There were significant increasing relationships between depression (OR 1.10, 95% CI 1.03-1.22), anxiety (OR 1.03, 95% CI 1.05-1.11), and QoL (OR 1.13, 95% CI 1.05-1.23) and MetS when associations were adjusted for other risk factors, but it was not the case for distress (OR 1.03, 95% CI 0.99-1.08). Conclusion. It might be better to consider MetS as a combination of biological and psychological risk factors. Thus, a person with metabolic disease should be recognized as a patient with these factors and be screened for all of them.
C1 [Sadeghi, Masoumeh] Isfahan Univ Med Sci, Cardiac Rehabil Res Ctr, Isfahan Cardiovasc Res Inst, WHO Collaborating Ctr, Esfahan, Iran.
   [Roohafza, Hamidreza; Talaei, Mohammad; Sarrafzadegan, Nizal] Isfahan Univ Med Sci, Cardiovasc Res Ctr, Isfahan Cardiovasc Res Inst, WHO Collaborating Ctr, Esfahan 814651148, Iran.
   [Pourmoghaddas, Zahra] Isfahan Univ Med Sci, Child Hlth Promot Res Ctr, Sch Med, Esfahan 814651148, Iran.
C3 Isfahan University of Medical Sciences; World Health Organization;
   Isfahan University of Medical Sciences; World Health Organization;
   Isfahan University of Medical Sciences
RP Sadeghi, M (corresponding author), Isfahan Univ Med Sci, Cardiac Rehabil Res Ctr, Isfahan Cardiovasc Res Inst, WHO Collaborating Ctr, POB 81465-1148, Esfahan, Iran.
EM m_sadeghi@crc.mui.ac.ir
RI pourmoghaddas, zahra/B-8213-2011; Sadeghi, Masoumeh/W-2291-2017;
   Sarrafzadegan, Nizal/V-5826-2017; Talaei, Mohammad/A-1819-2009
OI Sarrafzadegan, Nizal/0000-0002-8352-0540; Talaei,
   Mohammad/0000-0002-6901-3665; Sadeghi Mahonak,
   Masoumeh/0000-0001-7179-5558; Roohafza, Hamidreza/0000-0003-3582-0431;
   Pourmoghaddas, Zahra/0000-0002-5424-3919
CR [Anonymous], 2006, PREV CONTROL, DOI DOI 10.1016/J.PRECON.2006.10.003
   Azizi F, 2003, DIABETES RES CLIN PR, V61, P29, DOI 10.1016/S0168-8227(03)00066-4
   Carroll D, 2009, BIOL PSYCHIAT, V66, P91, DOI 10.1016/j.biopsych.2009.02.020
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Esmaillzadeh A, 2006, OBESITY, V14, P377, DOI 10.1038/oby.2006.50
   Everson-Rose SA, 2004, DIABETES CARE, V27, P2856, DOI 10.2337/diacare.27.12.2856
   Frisman GH, 2009, EUR J CARDIOVASC NUR, V8, P207, DOI 10.1016/j.ejcnurse.2009.01.004
   Goldberg D., 1992, General Health Questionnaire GHQ 12 Score. 16 Years. Annual Trend
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Katon WJ, 2003, BIOL PSYCHIAT, V54, P216, DOI 10.1016/S0006-3223(03)00273-7
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Miettola J, 2008, SCAND J PRIM HEALTH, V26, P203, DOI 10.1080/02813430802117624
   Montazeri Ali, 2003, Health Qual Life Outcomes, V1, P66, DOI 10.1186/1477-7525-1-66
   Montazeri Ali, 2003, Health Qual Life Outcomes, V1, P14, DOI 10.1186/1477-7525-1-14
   Noorbala AA, 2004, BRIT J PSYCHIAT, V184, P70, DOI 10.1192/bjp.184.1.70
   Oh EG, 2010, METABOLISM, V59, P1035, DOI 10.1016/j.metabol.2009.10.027
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Räikkönen K, 2007, DIABETES CARE, V30, P872, DOI 10.2337/dc06-1857
   Sarrafzadegan N, 2011, J HUM HYPERTENS, V25, P545, DOI 10.1038/jhh.2010.99
   Takeuchi T, 2009, DIABETES-METAB RES, V25, P762, DOI 10.1002/dmrr.1041
   Talaei M, 2012, NUTR METAB CARDIOVAS, V22, P434, DOI 10.1016/j.numecd.2010.08.003
   Tsai AG, 2008, OBESITY, V16, P59, DOI 10.1038/oby.2007.8
   Vanhala M, 2009, ACTA PSYCHIAT SCAND, V119, P137, DOI 10.1111/j.1600-0447.2008.01283.x
   Viinamäki H, 2009, ACTA PSYCHIAT SCAND, V120, P23, DOI 10.1111/j.1600-0447.2008.01333.x
   WILLIAMS A, 1990, HEALTH POLICY, V16, P199
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 27
TC 34
Z9 36
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2012
VL 2012
AR 380902
DI 10.1155/2012/380902
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA 955IR
UT WOS:000305011600001
PM 22675350
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Ren, J
   Kelley, RO
AF Ren, Jun
   Kelley, Robert O.
TI Cardiac Health in Women With Metabolic Syndrome: Clinical Aspects and
   Pathophysiology
SO OBESITY
LA English
DT Review
ID NITRIC-OXIDE SYNTHASE; POSTMENOPAUSAL HORMONE-THERAPY; ISOLATED
   VENTRICULAR MYOCYTES; ESTROGEN REPLACEMENT THERAPY;
   AMERICAN-HEART-ASSOCIATION; TYPE-2 DIABETES-MELLITUS;
   CARDIOVASCULAR-DISEASE; CONTRACTILE FUNCTION; GLUCOSE-METABOLISM;
   GENDER-DIFFERENCES
AB Although the classical cardiovascular risk factors (e. g., smoking and hypertension) are becoming more effectively managed, a continuous increase of the so-called "cardiometabolic risk" is noted. Starting from this century, the nomenclature "metabolic syndrome" has become more popular to identify a cluster of disorders including obesity, dyslipidemia, hypertension, and insulin resistance. It is a primary risk factor for diabetes and cardiovascular disease in both genders. Interestingly, the metabolic diseases display a distinct gender disparity with an apparent "female advantage" in the premenopausal women compared with age-matched men. However, women usually lose such "sex protection" following menopause or affliction of metabolic syndrome especially insulin resistance. A controversy exists in the medical literature concerning whether metabolic syndrome is a real syndrome or simply a cluster of risk factors. Several scenarios are speculated to contribute to the gender dimorphism in the cardiovascular sequelae in patients with metabolic syndrome including sex hormones, intrinsic organ function, and the risk factor profile (e. g., hypertension, dyslipidemia, obesity, sedentary lifestyle, and atherogenic diet). With the alarming rise of obesity prevalence, heart problems in metabolic syndrome continue to rise with a distinct gender dimorphism. Although female hearts seem to better tolerate the stress insults compared with the male counterparts, the female sex hormones such as estrogen can interact with certain risk factors to precipitate myopathic changes in the hearts. This synthetic review of recent literature suggests a role of gender disparity in myopathic factors and risk attributable to each metabolic component in the different prevalence of metabolic syndrome.
C1 [Ren, Jun; Kelley, Robert O.] Univ Wyoming, Coll Hlth Sci, Laramie, WY 82071 USA.
C3 University of Wyoming
RP Ren, J (corresponding author), Univ Wyoming, Coll Hlth Sci, Laramie, WY 82071 USA.
EM jren@uwyo.edu
RI Ren, Jun/ACG-5366-2022
OI Ren, Jun/0000-0002-0275-0783
FU NIH [P20 RR016474]; National Center for Research Resources (NCRR)
FX This publication was made possible by an NIH grant # P20 RR016474 from
   National Center for Research Resources (NCRR). We apologize to those
   authors whose important study cannot be covered due to space
   constraints.
CR Abdelmoneim I, 2002, East Mediterr Health J, V8, P18
   Balci H, 2005, MATURITAS, V50, P289, DOI 10.1016/j.maturitas.2004.07.002
   Barrett-Connor E, 2005, ANNU REV PUBL HEALTH, V26, P115, DOI 10.1146/annurev.publhealth.26.021304.144637
   Betancourt-Albrecht M, 2003, INT J IMPOT RES, V15, pS14, DOI 10.1038/sj.ijir.3901031
   Borissova AM, 2005, INT J CLIN PRACT, V59, P422, DOI 10.1111/j.1368-5031.2005.00209.x
   Brown R A, 2001, Cardiovasc Toxicol, V1, P35, DOI 10.1385/CT:1:1:35
   Brown RA, 2001, ENDOCR RES, V27, P399, DOI 10.1081/ERC-100107864
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Burdon KP, 2006, DIABETIC MED, V23, P228, DOI 10.1111/j.1464-5491.2005.01777.x
   Camper-Kirby D, 2001, CIRC RES, V88, P1020, DOI 10.1161/hh1001.090858
   Candore G, 2006, ANN NY ACAD SCI, V1089, P516, DOI 10.1196/annals.1386.051
   Cannon Christopher P, 2007, Clin Cornerstone, V8, P11, DOI 10.1016/S1098-3597(07)80025-1
   CAPASSO JM, 1983, BASIC RES CARDIOL, V78, P156, DOI 10.1007/BF01906669
   Ceylan-Isik AF, 2006, J APPL PHYSIOL, V100, P1638, DOI 10.1152/japplphysiol.01273.2005
   Ceylan-Isik AF, 2006, CLIN EXP PHARMACOL P, V33, P102, DOI 10.1111/j.1440-1681.2006.04331.x
   Ceylan-Isik AF, 2005, CARDIOLOGY, V1, P1
   Chandra D, 2002, DIABETES, V51, P3095, DOI 10.2337/diabetes.51.10.3095
   Chichlowska KL, 2008, PSYCHOSOM MED, V70, P986, DOI 10.1097/PSY.0b013e318183a491
   Chung AK, 2006, CIRCULATION, V113, P1597, DOI 10.1161/CIRCULATIONAHA.105.574400
   Collins P, 2002, CARDIOVASC RES, V53, P535, DOI 10.1016/S0008-6363(02)00224-9
   Dervaux N, 2008, ATHEROSCLEROSIS, V201, P413, DOI 10.1016/j.atherosclerosis.2007.11.032
   Di Carlo C, 2002, GYNECOL ENDOCRINOL, V16, P479, DOI 10.1080/gye.16.6.479.491
   Do Dat, 2006, Curr Atheroscler Rep, V8, P94, DOI 10.1007/s11883-006-0045-5
   DONG F, OBESITY SIL IN PRESS
   Duan JH, 2004, ENDOCRINE, V24, P33, DOI 10.1385/ENDO:24:1:033
   Ersen BOC, 2007, COMPARATIVE MED, V57, P493
   Esberg LB, 2004, COMP BIOCHEM PHYS A, V138, P141, DOI 10.1016/j.cbpb.2004.02.022
   FEIN FS, 1994, CARDIOVASC DRUG THER, V8, P65, DOI 10.1007/BF00877091
   Gambrell RD, 2004, CLIMACTERIC, V7, P225, DOI 10.1080/13697130400001349
   Golden KL, 2005, EUR J ENDOCRINOL, V152, P479, DOI 10.1530/eje.1.01845
   Goldie M Perno, 2005, Int J Dent Hyg, V3, P45
   Hall WL, 2006, AM J CLIN NUTR, V83, P592, DOI 10.1093/ajcn.83.3.592
   Hamdy O, 2006, CURR DIABETES REV, V2, P367, DOI 10.2174/1573399810602040367
   Hayward CS, 2001, CARDIOVASC RES, V49, P340, DOI 10.1016/S0008-6363(00)00280-7
   Holvoet P, 2008, Verh K Acad Geneeskd Belg, V70, P193
   Hong SC, 2007, MENOPAUSE, V14, P835, DOI 10.1097/gme.0b013e31802cddca
   Huang Terry T-K, 2007, Metabolic Syndrome and Related Disorders, V5, P365, DOI 10.1089/met.2007.0021
   Ito A, 2002, CIRC J, V66, P811, DOI 10.1253/circj.66.811
   Iwakura A, 2006, CIRCULATION, V113, P1605, DOI 10.1161/CIRCULATIONAHA.105.553925
   Jay MA, 2007, CURR DIABETES REV, V3, P33, DOI 10.2174/157339907779802067
   Kajstura J, 2006, J MOL CELL CARDIOL, V40, P425, DOI 10.1016/j.yjmcc.2005.12.013
   Kajstura J, 2001, DIABETES, V50, P1414, DOI 10.2337/diabetes.50.6.1414
   KARMAZYN M, 2008, CARDIOVASC RES
   Khoo Cheen Leen, 2005, J Br Menopause Soc, V11, P6
   Kim Ja-Young, 2004, Pediatr Endocrinol Rev, V1 Suppl 3, P428
   King K B, 2000, Prog Cardiovasc Nurs, V15, P36, DOI 10.1111/j.0889-7204.2000.080396.x
   Kordella Terri, 2005, Diabetes Forecast, V58, P42
   Lane PH, 2002, AM J PHYSIOL-RENAL, V283, pF589, DOI 10.1152/ajprenal.00368.2001
   Lastra-Gonzalez G, 2005, EXPERT OPIN PHARMACO, V6, P2209, DOI 10.1517/14656566.6.13.2209
   Latronico MVG, 2004, ANN NY ACAD SCI, V1015, P250, DOI 10.1196/annals.1302.021
   Li SY, 2003, PHARMACOL RES, V48, P127, DOI 10.1016/S1043-6618(03)00099-9
   Licata G, 2006, PANMINERVA MED, V48, P77
   Linfante A, 2004, CIRCULATION, V110, P664
   Lip GYH, 1997, AM HEART J, V134, P764, DOI 10.1016/S0002-8703(97)70062-0
   Lobo RA, 2008, MATURITAS, V60, P10, DOI 10.1016/j.maturitas.2008.02.008
   Louet Jean-Francois, 2004, Curr Atheroscler Rep, V6, P180, DOI 10.1007/s11883-004-0030-9
   Martins D, 2008, J NATL MED ASSOC, V100, P565, DOI 10.1016/S0027-9684(15)31304-3
   Matsui T, 2006, AM J PHYSIOL-ENDOC M, V290, pE789, DOI 10.1152/ajpendo.00564.2004
   Mercuro Giuseppe, 2003, Ital Heart J, V4, P363
   Milewicz A, 2005, GYNECOL ENDOCRINOL, V20, P68, DOI 10.1080/09513590400020989
   Mittendorfer B, 2005, J NUTR, V135, P681, DOI 10.1093/jn/135.4.681
   Mosca L, 2004, CIRCULATION, V109, P573, DOI 10.1161/01.CIR.0000115222.69428.C9
   Mosca L, 2001, CIRCULATION, V104, P499, DOI 10.1161/hc2901.092200
   Murph E, 2007, CARDIOVASC RES, V75, P478, DOI 10.1016/j.cardiores.2007.03.025
   Muscogiuri G, 2008, CURR VASC PHARMACOL, V6, P301, DOI 10.2174/157016108785909715
   Nilsson G, 2008, EUR J INTERN MED, V19, P520, DOI 10.1016/j.ejim.2008.01.018
   Norata GD, 2007, EUR J ENDOCRINOL, V156, P279, DOI 10.1530/eje.1.02338
   Norby FL, 2004, J ENDOCRINOL, V180, P175, DOI 10.1677/joe.0.1800175
   Norby FL, 2002, AM J PHYSIOL-ENDOC M, V283, pE658, DOI 10.1152/ajpendo.00003.2002
   O'Neill BT, 2005, J CLIN INVEST, V115, P2059, DOI 10.1172/JCI25900
   Onat A, 2005, METABOLISM, V54, P800, DOI 10.1016/j.metabol.2005.01.025
   Ordovas JM, 2007, GENDER MED, V4, pS111, DOI 10.1016/S1550-8579(07)80052-0
   Osawa H, 2008, CLIN ENDOCRINOL, V69, P74, DOI 10.1111/j.1365-2265.2007.03154.x
   Paudel Badri, 2007, Nepal Med Coll J, V9, P204
   Prentice RL, 2005, AM J EPIDEMIOL, V162, P404, DOI 10.1093/aje/kwi223
   QASIM AN, 2008, CLIN ENDOCRINOL OXF
   Ramasamy R, 1997, DIABETES, V46, P292, DOI 10.2337/diabetes.46.2.292
   Regitz-Zagrosek V, 2006, CLIN RES CARDIOL, V95, P136, DOI 10.1007/s00392-006-0351-5
   Regitz-Zagrosek V, 2007, GENDER MED, V4, pS162, DOI 10.1016/S1550-8579(07)80056-8
   Regitz-Zagrosek V, 2007, PROG CARDIOVASC DIS, V49, P241, DOI 10.1016/j.pcad.2006.08.011
   Ren J, 2000, AM J PHYSIOL-HEART C, V279, pH238, DOI 10.1152/ajpheart.2000.279.1.H238
   Ren J, 2004, ENDOCRINE, V25, P73, DOI 10.1385/ENDO:25:2:073
   Ren J, 2004, J ENDOCRINOL, V181, P1, DOI 10.1677/joe.0.1810001
   Ren J, 2003, AM J PHYSIOL-HEART C, V284, pH1800, DOI 10.1152/ajpheart.00866.2002
   Ren J, 1997, AM J PHYSIOL-HEART C, V272, pH148, DOI 10.1152/ajpheart.1997.272.1.H148
   Rossi R, 2004, DIABETES CARE, V27, P645, DOI 10.2337/diacare.27.3.645
   Schonberg MA, 2005, WOMEN HEALTH ISS, V15, P187, DOI 10.1016/j.whi.2005.03.003
   Schwanke ML, 2006, DIABETOLOGIA, V49, P1097, DOI 10.1007/s00125-006-0184-9
   Shimoni Y, 2003, J PHYSIOL-LONDON, V550, P401, DOI 10.1113/jphysiol.2003.041269
   Shimoni Y, 2001, J PHYSIOL-LONDON, V537, P83, DOI 10.1111/j.1469-7793.2001.0083k.x
   Simon JA, 2001, CIRCULATION, V103, P638, DOI 10.1161/01.cir.103.5.638
   Skafar DF, 1997, J CLIN ENDOCR METAB, V82, P3913, DOI 10.1210/jc.82.12.3913
   SMITH IJ, 2008, PHYSL GENOMICS
   Sowers James R, 2007, J Cardiometab Syndr, V2, P207, DOI 10.1111/j.1559-4564.2007.06656.x
   Sowers JR, 1998, ARCH INTERN MED, V158, P617, DOI 10.1001/archinte.158.6.617
   Stefan N, 2008, ENDOCR REV, V29, P939, DOI 10.1210/er.2008-0009
   Stice JP, 2008, MOL MED, V14, P517, DOI 10.2119/2008-00026.Stice
   Strohmer B, 2007, WIEN KLIN WOCHENSCHR, V119, P544, DOI 10.1007/s00508-007-0840-1
   Subbiah MTR, 2002, BRAZ J MED BIOL RES, V35, P271, DOI 10.1590/S0100-879X2002000300001
   Sullivan PW, 2007, OBESITY, V15, P511, DOI 10.1038/oby.2007.580
   Swarbrick Michael M., 2008, Metabolic Syndrome and Related Disorders, V6, P87, DOI 10.1089/met.2007.0029
   Tao L, 2007, CIRCULATION, V115, P1408, DOI 10.1161/CIRCULATIONAHA.106.666941
   Thompson J, 2003, CLIN EXP PHARMACOL P, V30, P1, DOI 10.1046/j.1440-1681.2003.03790.x
   Tian R, 2005, CIRC RES, V96, P139, DOI 10.1161/01.RES.0000156076.17807.1F
   Tschöpe C, 2003, INTERNIST, V44, P806, DOI 10.1007/s00108-003-0947-z
   Uhl K, 2007, CLIN PHARMACOL THER, V81, P600, DOI 10.1038/sj.clpt.6100112
   Verdonk P., 2008, Adv Health Sci Educ Theory Pract
   Villablanca AC, 2002, J APPL PHYSIOL, V92, P1064, DOI 10.1152/japplphysiol.00374.2001
   Warnes CA, 2008, CIRCULATION, V118, P3, DOI 10.1161/CIRCULATIONAHA.108.785899
   WEINER CP, 1994, P NATL ACAD SCI USA, V91, P5212, DOI 10.1073/pnas.91.11.5212
   WILLIAMSON JR, 1986, DIABETES, V35, P20, DOI 10.2337/diabetes.35.1.20
   Wilson Peter W F, 2002, Am J Geriatr Cardiol, V11, P119
   Wold LE, 2005, ACTA PHARMACOL SIN, V26, P908, DOI 10.1111/j.1745-7254.2005.00146.x
   Yabuki A, 2006, EXP ANIM TOKYO, V55, P17, DOI 10.1538/expanim.55.17
   Zhang XC, 2003, ENDOCR RES, V29, P227, DOI 10.1081/ERC-120022318
   Zhong J, 2006, J LAB CLIN MED, V147, P91, DOI 10.1016/j.lab.2005.10.001
NR 116
TC 83
Z9 91
U1 1
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD JUN
PY 2009
VL 17
IS 6
BP 1114
EP 1123
DI 10.1038/oby.2009.8
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 450EG
UT WOS:000266383200004
PM 19214173
OA Bronze
DA 2025-06-11
ER

PT J
AU Heppner, PS
   Crawford, EF
   Haji, UA
   Afari, N
   Hauger, RL
   Dashevsky, BA
   Horn, PS
   Nunnink, SE
   Baker, DG
AF Heppner, Pia S.
   Crawford, Eric F.
   Haji, Uzair A.
   Afari, Niloofar
   Hauger, Richard L.
   Dashevsky, Boris A.
   Horn, Paul S.
   Nunnink, Sarah E.
   Baker, Dewleen G.
TI The association of posttraumatic stress disorder and metabolic syndrome:
   a study of increased health risk in veterans
SO BMC MEDICINE
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; 3RD NATIONAL-HEALTH; ALLOSTATIC LOAD;
   DIABETES-MELLITUS; PLASMA; DIAGNOSIS; ILLNESS; NEUROENDOCRINE;
   PREVALENCE; DEPRESSION
AB Background: There is accumulating evidence for a link between trauma exposure, posttraumatic stress disorder (PTSD) and diminished health status. To assess PTSD-related biological burden, we measured biological factors that comprise metabolic syndrome, an important established predictor of morbidity and mortality, as a correlate of long-term health risk in PTSD.
   Methods: We analyzed clinical data from 253 male and female veterans, corresponding to five factors linked to metabolic syndrome (systolic and diastolic blood pressure, waist-to-hip ratio and fasting measures of high-density lipoprotein (HDL) cholesterol, serum triglycerides and plasma glucose concentration). Clinical cut-offs were defined for each biological parameter based on recommendations from the World Health Organization and the National Cholesterol Education Program. Controlling for relevant variables including sociodemographic variables, alcohol/substance/nicotine use and depression, we examined the impact of PTSD on metabolic syndrome using a logistic regression model.
   Results: Two-fifths (40%) of the sample met criteria for metabolic syndrome. Of those with PTSD (n = 139), 43% met criteria for metabolic syndrome. The model predicted metabolic syndrome well (- 2 log likelihood = 316.650, chi-squared = 23.731, p = 0.005). Veterans with higher severity of PTSD were more likely to meet diagnostic criteria for metabolic syndrome (Wald = 4.76, p = 0.03).
   Conclusion: These findings provide preliminary evidence linking higher severity of PTSD with risk factors for diminished health and increased morbidity, as represented by metabolic syndrome.
C1 [Heppner, Pia S.; Haji, Uzair A.; Afari, Niloofar; Hauger, Richard L.; Nunnink, Sarah E.; Baker, Dewleen G.] Vet Affairs San Diego Hlth Care Syst, Res Serv, San Diego, CA 92161 USA.
   [Heppner, Pia S.; Afari, Niloofar; Hauger, Richard L.; Baker, Dewleen G.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
   [Crawford, Eric F.] Durham Vet Affairs Med Ctr, Durham, NC 27705 USA.
   [Dashevsky, Boris A.; Horn, Paul S.] Cincinnati Vet Affairs Med Ctr, Psychiat Serv, Cincinnati, OH 45220 USA.
   [Horn, Paul S.] Univ Cincinnati, Dept Math Sci, Cincinnati, OH 45221 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA San Diego Healthcare System; University of California System;
   University of California San Diego; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); Durham VA Medical Center; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Cincinnati VA Medical Center; University System of Ohio; University of
   Cincinnati
RP Heppner, PS (corresponding author), Vet Affairs San Diego Hlth Care Syst, Res Serv, MC 151,Jolla Village Dr, San Diego, CA 92161 USA.
EM pheppner@ucsd.edu; Eric.Crawford@va.gov; uzair.haji2@va.gov;
   nafari@ucsd.edu; rhauger@ucsd.edu; boris_dashevsky@hotmail.com;
   paul.horn@uc.edu; sarah.nunnink@va.gov; dgbaker@ucsd.edu
RI Horn, Paul/LPA-6457-2024; Baker, Dewleen/O-4957-2019
FU VACO Research funds; NIH [R01AR51524]; VA Center of Excellence for
   Stress and Mental Health
FX DGB and RLH are supported by VACO Research funds (VA Merit Review,
   VA-DOD, MIRECC, HSR&D, and the Office of Environmental Hazards). This
   work is supported in part by these funds. NA is supported in part by NIH
   R01AR51524. PSH (1), NA, DGB, RLH, and SEN are also supported by the VA
   Center of Excellence for Stress and Mental Health. We thank the
   clinicians at the Veterans Affairs of Cincinnati who participated in the
   collection of data and Laura Harder who provided assistance with
   manuscript formatting.
CR Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Babic D, 2007, PSYCHIAT DANUB, V19, P68
   Baker D.G., 2003, CYTOKINES MENTAL HLT, P301
   Baker DG, 1999, AM J PSYCHIAT, V156, P585
   Baker DG, 2001, NEUROIMMUNOMODULAT, V9, P209, DOI 10.1159/000049028
   BLAKE DD, 1995, J TRAUMA STRESS, V8, P75, DOI 10.1007/BF02105408
   Blanchard MS, 2006, AM J EPIDEMIOL, V163, P66, DOI 10.1093/aje/kwj008
   Boscarino JA, 2006, ANN EPIDEMIOL, V16, P248, DOI 10.1016/j.annepidem.2005.03.009
   Boscarino JA, 2004, ANN NY ACAD SCI, V1032, P141, DOI 10.1196/annals.1314.011
   Bremner JD, 1997, AM J PSYCHIAT, V154, P624
   Brietzke SA, 2007, MED CLIN N AM, V91, P1041, DOI 10.1016/j.mcna.2007.06.005
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   CARROLL BJ, 1968, BRIT MED J, V3, P285, DOI 10.1136/bmj.3.5613.285
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Chrousos George P., 2000, Journal of Allergy and Clinical Immunology, V106, pS275
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   Chrousos GP, 1998, ANN NY ACAD SCI, V851, P311, DOI 10.1111/j.1749-6632.1998.tb09006.x
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   de Zeeuw D, 2008, NAT CLIN PRACT CARD, V5, pS10, DOI 10.1038/ncpcardio1271
   Deuschle M, 1997, PSYCHONEUROENDOCRINO, V22, P493, DOI 10.1016/S0306-4530(97)00046-2
   Deuschle M, 1998, STRESS, V2, P281, DOI 10.3109/10253899809167292
   First MB., 1997, Structured Clinical Interview for DSM-IV Axis I Disorders-Clinican Version (SCID-CV)
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Geracioti TD, 2001, AM J PSYCHIAT, V158, P1227, DOI 10.1176/appi.ajp.158.8.1227
   Glover DA, 2006, PSYCHIATRY, V69, P191, DOI 10.1521/psyc.2006.69.3.191
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Heiskanen TH, 2006, J CLIN PSYCHIAT, V67, P1422, DOI 10.4088/JCP.v67n0913
   Jakovljevic Miro, 2006, Psychiatr Danub, V18, P169
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   Kang HK, 2006, ANN EPIDEMIOL, V16, P381, DOI 10.1016/j.annepidem.2005.03.004
   KIMERLING R, 1994, J CONSULT CLIN PSYCH, V62, P333, DOI 10.1037/0022-006X.62.2.333
   Kohli P, 2006, JAMA-J AM MED ASSOC, V295, P819, DOI 10.1001/jama.295.7.819
   Krause N, 2004, PSYCHOL AGING, V19, P637, DOI 10.1037/0882-7974.19.4.637
   Laaksonen DE, 2002, AM J EPIDEMIOL, V156, P1070, DOI 10.1093/aje/kwf145
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Loucks EB, 2007, ANN EPIDEMIOL, V17, P782, DOI 10.1016/j.annepidem.2007.05.003
   Maia DB, 2008, J AFFECT DISORDERS, V107, P259, DOI 10.1016/j.jad.2007.08.013
   McEwen BS, 2000, NEUROPSYCHOPHARMACOL, V22, P108, DOI 10.1016/S0893-133X(99)00129-3
   McEwen BS, 2002, PSYCHIAT CLIN N AM, V25, P469, DOI 10.1016/S0193-953X(01)00009-0
   MCEWEN BS, 1993, ARCH INTERN MED, V153, P2093, DOI 10.1001/archinte.153.18.2093
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Pervanidou P, 2006, CURR OPIN CLIN NUTR, V9, P589, DOI 10.1097/01.mco.0000241669.24923.8d
   Pizarro J, 2006, ARCH GEN PSYCHIAT, V63, P193, DOI 10.1001/archpsyc.63.2.193
   SACHAR EJ, 1970, ARCH GEN PSYCHIAT, V23, P289
   Seeman TE, 1997, ARCH INTERN MED, V157, P2259
   Seeman TE, 2001, P NATL ACAD SCI USA, V98, P4770, DOI 10.1073/pnas.081072698
   SMEETS RMW, 1993, COMPOSITE INTERNATIO
   Vieweg WVR, 2007, ACTA PSYCHIAT SCAND, V116, P483, DOI 10.1111/j.1600-0447.2007.01071.x
   Vieweg W Victor R, 2006, Prim Care Companion J Clin Psychiatry, V8, P25
   Violanti John M, 2006, Int J Emerg Ment Health, V8, P227
   Weathers FW, 1999, PSYCHOL ASSESSMENT, V11, P124, DOI 10.1037/1040-3590.11.2.124
   Weber B, 2000, PSYCHONEUROENDOCRINO, V25, P765, DOI 10.1016/S0306-4530(00)00023-8
   WHO, 1999, DEF DIAGN CLASS DIAB
   YOUNG EA, 1994, ARCH GEN PSYCHIAT, V51, P701
NR 55
TC 120
Z9 136
U1 0
U2 12
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1741-7015
J9 BMC MED
JI BMC Med.
PD JAN 9
PY 2009
VL 7
AR 1
DI 10.1186/1741-7015-7-1
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA 419BX
UT WOS:000264195200001
PM 19134183
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hashizume, K
   Suzuki, S
   Hara, M
   Komatsu, A
   Yamashita, K
AF Hashizume, Kiyoshi
   Suzuki, Satoru
   Hara, Masahiro
   Komatsu, Ai
   Yamashita, Koh
TI Metabolic syndrome and age-related dementia: Endocrinological aspects of
   adaptation to aging
SO MECHANISMS OF AGEING AND DEVELOPMENT
LA English
DT Review
DE metabolic syndrome; cognition disorder; thyroid hormone; growth hormone
ID SERUM-CHOLESTEROL CONCENTRATION; DOSE SIMVASTATIN THERAPY; LARGE-SCALE
   COHORT; THYROID-HORMONE; PREVENTION COHORT; JAPANESE PATIENTS; CORONARY
   EVENTS; DISEASE; HYPERCHOLESTEROLEMIA; MORTALITY
AB Metabolic syndrome is one of the determinants of lifespan in Japan. In order to prevent the acute vascular events, intervention is recommended. However, management of patients with this syndrome increased the number of patients with cognition decline and depressive state.
   Endocrinological studies with human and experimental animals showed that there is a negative relationship between progression of metabolic syndrome and occurrence of mental disorders. In this review, we summarize our clinical and experimental data, and discuss on the mechanism of the metabolic syndrome prevention of progression of age-related mental disorder. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
EM hshzmk@hsp.md.shinshu-u.ac.jp
RI Suzuki, Satoru/G-3584-2011
CR BAURA GD, 1993, J CLIN INVEST, V92, P1824, DOI 10.1172/JCI116773
   Bruno G, 2004, DIABETES CARE, V27, P2689, DOI 10.2337/diacare.27.11.2689
   BU GJ, 1994, J BIOL CHEM, V269, P18521
   Cooper JA, 1999, CELL, V97, P671, DOI 10.1016/S0092-8674(00)80778-3
   CORDER EH, 1994, NAT GENET, V7, P180, DOI 10.1038/ng0694-180
   Esaki T, 2003, ENDOCRINOLOGY, V144, P4117, DOI 10.1210/en.2003-0414
   Gauthier K, 1999, EMBO J, V18, P623, DOI 10.1093/emboj/18.3.623
   HASHIZUME K, 1986, ENDOCRINOLOGY, V119, P1063, DOI 10.1210/endo-119-3-1063
   HASHIZUME K, 1992, J BONE MINER METAB, V10, P173
   Hurst RT, 2003, ANN INTERN MED, V139, P824, DOI 10.7326/0003-4819-139-10-200311180-00010
   ICHIKAWA K, 1985, ENDOCRINOLOGY, V117, P1749, DOI 10.1210/endo-117-5-1749
   Ichikawa Kazuo, 1998, Japanese Journal of Geriatrics, V35, P771
   Kanaya AM, 2004, ARCH INTERN MED, V164, P1327, DOI 10.1001/archinte.164.12.1327
   Katakura M, 2004, METABOLISM, V53, P949, DOI 10.1016/j.metabol.2004.02.024
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   LAVIN TN, 1989, ENDOCRINOLOGY, P562
   Libby P, 2001, CIRCULATION, V104, P365, DOI 10.1161/01.CIR.104.3.365
   Logroscino G, 2004, BMJ-BRIT MED J, V328, P548, DOI 10.1136/bmj.37977.495729.EE
   Mabuchi H, 2002, CIRC J, V66, P1096, DOI 10.1253/circj.66.1096
   Matsuzaki M, 2002, CIRC J, V66, P1087, DOI 10.1253/circj.66.1087
   Miller LJ, 2004, ANN PHARMACOTHER, V38, P91, DOI 10.1345/aph.1D104
   OHARA N, 1995, MINER ELECTROL METAB, V21, P63
   Puigserver P, 1998, CELL, V92, P829, DOI 10.1016/S0092-8674(00)81410-5
   Seidner G, 1998, NAT GENET, V18, P188, DOI 10.1038/ng0298-188
   Viles-Gonzalez JF, 2004, EUR HEART J, V25, P1197, DOI 10.1016/j.ehj.2004.03.011
NR 25
TC 4
Z9 4
U1 0
U2 2
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0047-6374
EI 1872-6216
J9 MECH AGEING DEV
JI Mech. Ageing Dev.
PD JUN
PY 2006
VL 127
IS 6
BP 507
EP 510
DI 10.1016/j.mad.2006.01.026
PG 4
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA 047YZ
UT WOS:000237915900002
PM 16574195
DA 2025-06-11
ER

PT J
AU McDermott, KA
   Rao, MR
   Nagarathna, R
   Murphy, EJ
   Burke, A
   Nagendra, RH
   Hecht, FM
AF McDermott, Kelly A.
   Rao, Mohan Raghavendra
   Nagarathna, Raghuram
   Murphy, Elizabeth J.
   Burke, Adam
   Nagendra, Ramarao Hongasandra
   Hecht, Frederick M.
TI A yoga intervention for type 2 diabetes risk reduction: a pilot
   randomized controlled trial
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE Yoga; Prediabetes; Type 2 diabetes; India; Randomized controlled pilot
ID INSULIN-RESISTANCE-SYNDROME; IMPAIRED FASTING GLUCOSE; METABOLIC
   SYNDROME; PHYSICAL-ACTIVITY; LIFE-STYLE; EXERCISE; PREVENTION; MELLITUS;
   PREVALENCE; BENEFITS
AB Background: Type 2 diabetes is a major health problem in many countries including India. Yoga may be an effective type 2 diabetes prevention strategy in India, particularly given its cultural familiarity.
   Methods: This was a parallel, randomized controlled pilot study to collect feasibility and preliminary efficacy data on yoga for diabetes risk factors among people at high risk of diabetes. Primary outcomes included: changes in BMI, waist circumference, fasting blood glucose, postprandial blood glucose, insulin, insulin resistance, blood pressure, and cholesterol. We also looked at measures of psychological well-being including changes in depression, anxiety, positive and negative affect and perceived stress. Forty-one participants with elevated fasting blood glucose in Bangalore, India were randomized to either yoga (n = 21) or a walking control (n = 20). Participants were asked to either attend yoga classes or complete monitored walking 3-6 days per week for eight weeks. Randomization and allocation was performed using computer-generated random numbers and group assignments delivered in sealed, opaque envelopes generated by off-site study staff. Data were analyzed based on intention to treat.
   Results: This study was feasible in terms of recruitment, retention and adherence. In addition, yoga participants had significantly greater reductions in weight, waist circumference and BMI versus control (weight -0.8 +/- 2.1 vs. 1.4 +/- 3.6, p = 0.02; waist circumference -4.2 +/- 4.8 vs. 0.7 +/- 4.2, p < 0.01; BMI -0.2 +/- 0.8 vs. 0.6 +/- 1.6, p = 0.05). There were no between group differences in fasting blood glucose, postprandial blood glucose, insulin resistance or any other factors related to diabetes risk or psychological well-being. There were significant reductions in systolic and diastolic blood pressure, total cholesterol, anxiety, depression, negative affect and perceived stress in both the yoga intervention and walking control over the course of the study.
   Conclusion: Among Indians with elevated fasting blood glucose, we found that participation in an 8-week yoga intervention was feasible and resulted in greater weight loss and reduction in waist circumference when compared to a walking control. Yoga offers a promising lifestyle intervention for decreasing weight-related type 2 diabetes risk factors and potentially increasing psychological well-being.
C1 [McDermott, Kelly A.; Hecht, Frederick M.] Univ Calif San Francisco, Osher Ctr Integrat Med, San Francisco, CA 94115 USA.
   [Rao, Mohan Raghavendra; Nagarathna, Raghuram; Nagendra, Ramarao Hongasandra] Swami Vivekananda Yoga Anusandhana Samsthana, Bangalore, Karnataka, India.
   [Murphy, Elizabeth J.] Univ Calif San Francisco, Dept Med, Div Endocrinol & Metab, San Francisco, CA 94115 USA.
   [Burke, Adam] San Francisco State Univ, Inst Holist Hlth Studies, San Francisco, CA 94132 USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   California State University System; San Francisco State University
RP McDermott, KA (corresponding author), Univ Calif San Francisco, Osher Ctr Integrat Med, 1545 Div St, San Francisco, CA 94115 USA.
EM mcdermottk@ocim.ucsf.edu
RI Nagaratna, R/GQI-3110-2022; Rao, Raghavendra/KJM-4435-2024
OI Hecht, Frederick/0000-0002-5782-1171; Raghuram,
   Nagarathna/0000-0002-1666-1407
FU US National Institutes of Health [NCCAM R21 AT01942]; National Center
   for Complementary and Integrative Health [T32AT003997, K24AT007827]
   Funding Source: NIH RePORTER
FX This study was supported with a grant from the US National Institutes of
   Health, NCCAM R21 AT01942.
CR Alexander GK, 2013, COMPLEMENT THER MED, V21, P14, DOI 10.1016/j.ctim.2012.11.001
   Blair SN, 1996, MED SCI SPORT EXER, V28, P335, DOI 10.1097/00005768-199603000-00009
   Boulé NG, 2001, JAMA-J AM MED ASSOC, V286, P1218, DOI 10.1001/jama.286.10.1218
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   COHEN S, 1988, CLAR SYMP, P31
   Desai A, 2009, CURR SCI INDIA, V97, P356
   Danucalov MAD, 2008, APPL PSYCHOPHYS BIOF, V33, P77, DOI 10.1007/s10484-008-9053-2
   Gupta A, 2003, DIABETES RES CLIN PR, V61, P69, DOI 10.1016/S0168-8227(03)00085-8
   Hagins M, DOES PRACTICING HATH
   Hagins Marshall, 2007, BMC Complement Altern Med, V7, P40, DOI 10.1186/1472-6882-7-40
   Innes KE, 2005, J AM BOARD FAM PRACT, V18, P491, DOI 10.3122/jabfm.18.6.491
   Iyengar B.K.S., 1995, Light On Yoga: Yoga Dipika
   Jyotsna Viveka P, 2012, Indian J Endocrinol Metab, V16, P423, DOI 10.4103/2230-8210.95692
   Kanaya AM, 2014, J DIABETES COMPLICAT, V28, P406, DOI 10.1016/j.jdiacomp.2013.12.001
   Katzmarzyk PT, 2003, MED SCI SPORT EXER, V35, P1703, DOI 10.1249/01.MSS.0000089337.73244.9B
   Kosuri M, 2009, METAB SYNDR RELAT D, V7, P515, DOI 10.1089/met.2009.0011
   Laaksonen DE, 2005, DIABETES, V54, P158, DOI 10.2337/diabetes.54.1.158
   Misra A, 2005, DIABETES CARE, V28, P398, DOI 10.2337/diacare.28.2.398
   Misra A, 2004, NUTRITION, V20, P482, DOI 10.1016/j.nut.2004.01.020
   Nagarathna R, 2012, INT J DIABETES DEV C, V32, P122, DOI 10.1007/s13410-012-0078-y
   Nathan DM, 2007, DIABETES CARE, V30, P753, DOI 10.2337/dc07-9920
   Peterson JC, 2012, ARCH INTERN MED, V172, P329, DOI 10.1001/archinternmed.2011.1311
   Ray US, 2011, EVID-BASED COMPL ALT, V2011, P1, DOI 10.1093/ecam/neq046
   Richter EA, 2001, J PHYSIOL-LONDON, V535, P313, DOI 10.1111/j.1469-7793.2001.t01-2-00313.x
   Ross A, 2010, J ALTERN COMPLEM MED, V16, P3, DOI 10.1089/acm.2009.0044
   Sahay B K, 1986, J Assoc Physicians India, V34, P645
   Seo DY, 2012, KOREAN J PHYSIOL PHA, V16, P175, DOI 10.4196/kjpp.2012.16.3.175
   Svatmarama Akers BD, 2002, HATHA YOGA PRADIPIKA
   Telles S, 1996, J Altern Complement Med, V2, P479, DOI 10.1089/acm.1996.2.479
   Telles Shirley, 1994, Indian Journal of Physiology and Pharmacology, V38, P133
   Tuomilehto Jaakko, 2001, New England Journal of Medicine, V344, P1343, DOI 10.1056/NEJM200105033441801
   Wallace TM, 2004, DIABETES CARE, V27, P1487, DOI 10.2337/diacare.27.6.1487
   WATSON D, 1988, J PERS SOC PSYCHOL, V54, P1063, DOI 10.1037/0022-3514.54.6.1063
   White IR, 2012, CLIN TRIALS, V9, P396, DOI 10.1177/1740774512450098
   Whiting DR, 2011, DIABETES RES CLIN PR, V94, P311, DOI 10.1016/j.diabres.2011.10.029
   World of Health Organization (WHO), 2006, International diabetes federation
   Yang K, 2011, EVID-BASED COMPL ALT, V2011, P1, DOI 10.1093/ecam/nep117
   Zanuso S, 2010, ACTA DIABETOL, V47, P15, DOI 10.1007/s00592-009-0126-3
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 39
TC 64
Z9 71
U1 1
U2 31
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD JUL 1
PY 2014
VL 14
AR 212
DI 10.1186/1472-6882-14-212
PG 14
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA AL1LZ
UT WOS:000338888200001
PM 24980650
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Degirmenci, DM
   Ugurlu, YK
   Alemdar, DK
AF Degirmenci, Duygu Mataraci
   Ugurlu, Yasemin Kalkan
   Alemdar, Dilek Kucuk
TI The relationship between coronavirus anxiety level and emotional eating
   in individuals with metabolic syndrome
SO PSYCHOLOGY HEALTH & MEDICINE
LA English
DT Article
DE Anxiety; COVID-19; eating; metabolic syndrome
ID COVID-19; DEPRESSION
AB This study used a descriptive, cross-sectional and relational screening model. The full sampling method was used in this study. The study was completed with 105 individuals with MetS attending the outpatient nutrition clinic and 109 non-MetS individuals without MetS diagnosis, who also attended the outpatient nutrition clinic. The data included anthropometric measurements, biochemical findings, blood pressure, a survey form, the Coronavirus Anxiety Scale (CAS), and the Emotional Eating Scale (EES). The coronavirus anxiety scale scores of individuals with MetS were found to be statistically significantly higher than those of the non-MetS group (p <0.05). The difference in the emotional eating scale scores between the MetS and non-MetS groups was not significant (p <0.05). Individuals with MetS had higher coronavirus anxiety levels than those without MetS; however, there was no difference between participants with and without MetS in terms of emotional eating behavior.
C1 [Degirmenci, Duygu Mataraci] Ordu Univ, Fac Hlth Sci, Dept Nutr & Dietet, Ordu, Turkey.
   [Ugurlu, Yasemin Kalkan; Alemdar, Dilek Kucuk] Ordu Univ, Fac Hlth Sci, Dept Nursing, Ordu, Turkey.
C3 Ordu University; Ordu University
RP Alemdar, DK (corresponding author), Ordu Univ, Fac Hlth Sci, TR-52200 Ordu, Turkey.
EM dilekkucuk@atauni.edu.tr
RI mataracı değirmenci, duygu/LTG-0468-2024; Kalkan Uğurlu,
   Yasemin/GLS-8636-2022
OI Kucuk Alemdar, Dilek/0000-0002-7275-0666; Kalkan ugurlu,
   Yasemin/0000-0003-0096-5593; MATARACI DEGIRMENCI,
   Duygu/0000-0003-2136-1545
CR Al-Musharaf S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12102923
   Alessi J, 2020, DIABETOL METAB SYNDR, V12, DOI 10.1186/s13098-020-00584-6
   Arslantas H, 2020, TURK PSIKIYATR DERG, V31, P122, DOI 10.5080/u23520
   Braden A, 2018, APPETITE, V125, P410, DOI 10.1016/j.appet.2018.02.022
   Carlos M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12082224
   Chiyanika C, 2020, PEDIATR OBES, V15, DOI 10.1111/ijpo.12653
   Chopra S, 2020, DIABETES METAB SYND, V14, P2021, DOI 10.1016/j.dsx.2020.09.034
   Evren C, 2022, DEATH STUD, V46, P1052, DOI 10.1080/07481187.2020.1774969
   Garaulet M, 2012, NUTR HOSP, V27, P645, DOI [10.1590/S0212-16112012000200043, 10.3305/nh.2012.27.2.5659]
   Gregory JW, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00669
   Hoffmann MS, 2021, J PSYCHIATR RES, V137, P117, DOI 10.1016/j.jpsychires.2021.02.052
   Konttinen H, 2019, INT J BEHAV NUTR PHY, V16, DOI 10.1186/s12966-019-0791-8
   Lee SA, 2020, J ANXIETY DISORD, V74, DOI 10.1016/j.janxdis.2020.102268
   López-Moreno M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113445
   Mattei G, 2018, J NERV MENT DIS, V206, P316, DOI 10.1097/NMD.0000000000000807
   Mattioli AV, 2020, NUTR METAB CARDIOVAS, V30, P1409, DOI 10.1016/j.numecd.2020.05.020
   Nolan LJ, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081711
   Samuel L, 2018, ARCH GERONTOL GERIAT, V78, P127, DOI 10.1016/j.archger.2018.06.012
   Shinkov A, 2018, POSTGRAD MED, V130, P251, DOI 10.1080/00325481.2018.1410054
   Van Rheenen TE, 2020, J AFFECT DISORDERS, V275, P69, DOI 10.1016/j.jad.2020.06.037
NR 20
TC 0
Z9 0
U1 2
U2 4
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1354-8506
EI 1465-3966
J9 PSYCHOL HEALTH MED
JI Psychol. Health Med.
PD NOV 26
PY 2023
VL 28
IS 10
BP 3156
EP 3162
DI 10.1080/13548506.2022.2080841
EA MAY 2022
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA DU0Q9
UT WOS:000799837800001
PM 35608222
DA 2025-06-11
ER

PT J
AU Schwartz, T
   Bedynerman, K
AF Schwartz, T.
   Bedynerman, K.
TI UTILIZING PHARMACODYNAMIC PROPERTIES OF SECOND-GENERATION ANTI
   PSYCHOTICS TO GUIDE TREATMENT
SO DRUGS OF TODAY
LA English
DT Review
DE Antipsychotics; Atypical antipsychotics; Pharmacokinetics;
   Pharmacodynamics; Dosing strategies
ID SEROTONIN REUPTAKE INHIBITORS; DOUBLE-BLIND; METABOLIC SYNDROME;
   ANTIDEPRESSANT; RISPERIDONE; EFFICACY; ANTIPSYCHOTICS; ZIPRASIDONE;
   MONOTHERAPY; OLANZAPINE
AB Second-generation antipsychotics (SGAs) are used for the treatment of multiple psychiatric disorders including schizophrenia, bipolar depression, bipolar mania, autism and major depressive disorder. Additionally, their off-label use has been expanding to include other disorders as well, including post-traumatic stress disorder, obsessive compulsive disorder, generalized anxiety disorder, eating disorders and personality disorders. All SGAs share common properties; however, each individual SGA has a unique pharmacodynamic profile that may be utilized to guide and individualize treatment.
C1 [Schwartz, T.; Bedynerman, K.] SUNY Upstate Med Univ, Dept Psychiat, Syracuse, NY 13210 USA.
C3 State University of New York (SUNY) System; State University of New York
   (SUNY) Upstate Medical Center
RP Schwartz, T (corresponding author), SUNY Upstate Med Univ, Dept Psychiat, 730 E Adams St, Syracuse, NY 13210 USA.
EM SchwartT@upstate.edu
CR [Anonymous], 2011, CYMB DUL HYDR
   [Anonymous], 2011, SAPHR AS MAL
   [Anonymous], 2011, ZYPR OL
   [Anonymous], 2010, GEOD ZIPR
   [Anonymous], 2011, LAT LUR HYDR
   [Anonymous], 2011, STRATT AT HYDR
   [Anonymous], SER QUET FUM
   [Anonymous], 2011, RISP RISP
   [Anonymous], 2011, INV PAL
   [Anonymous], 2012, ABL AR
   [Anonymous], 2012, FAN IL
   [Anonymous], 2011, SER XR QUET FUM
   Bandelow B, 2010, INT J NEUROPSYCHOPH, V13, P305, DOI 10.1017/S1461145709990423
   Bissada H, 2008, AM J PSYCHIAT, V165, P1281, DOI 10.1176/appi.ajp.2008.07121900
   Boulay D, 2010, NEUROPSYCHOPHARMACOL, V35, P416, DOI 10.1038/npp.2009.144
   Burris KD, 2002, J PHARMACOL EXP THER, V302, P381, DOI 10.1124/jpet.102.033175
   Catena-Dell'Osso M, 2011, CURR MED CHEM, V18, P245, DOI 10.2174/092986711794088353
   Citrome Leslie, 2011, Clin Schizophr Relat Psychoses, V4, P251, DOI 10.3371/CSRP.4.4.5
   Citrome L, 2009, J CLIN PSYCHIAT, V70, P975, DOI 10.4088/JCP.08m04531
   Cohrs S, 2004, PSYCHOPHARMACOLOGY, V174, P421, DOI 10.1007/s00213-003-1759-5
   Conley R, 2006, CURR MED RES OPIN, V22, P1879, DOI 10.1185/030079906X132613
   Corya SA, 2006, J CLIN PSYCHIAT, V67, P798, DOI 10.4088/JCP.v67n0514
   Croxtall JD, 2010, CNS DRUGS, V24, P245, DOI 10.2165/11203830-000000000-00000
   Dekeyne A, 2008, PSYCHOPHARMACOLOGY, V199, P549, DOI 10.1007/s00213-008-1177-9
   Haas M, 2009, J CHILD ADOL PSYCHOP, V19, P611, DOI 10.1089/cap.2008.0144
   Hedlund PB, 2009, PSYCHOPHARMACOLOGY, V206, P345, DOI 10.1007/s00213-009-1626-0
   Jones MP, 2010, INT J CLIN PHARM TH, V48, P383
   Khanna S, 2005, BRIT J PSYCHIAT, V187, P229, DOI 10.1192/bjp.187.3.229
   King MV, 2008, TRENDS PHARMACOL SCI, V29, P482, DOI 10.1016/j.tips.2008.07.001
   Maher AR, 2011, JAMA-J AM MED ASSOC, V306, P1359, DOI 10.1001/jama.2011.1360
   Marek GJ, 2003, NEUROPSYCHOPHARMACOL, V28, P402, DOI 10.1038/sj.npp.1300057
   Meyer JM, 2008, SCHIZOPHR RES, V101, P273, DOI 10.1016/j.schres.2007.12.487
   Mueser K.T., 2008, Clinical handbook of schizophrenia
   NYBERG S, 2010, EUR PSYCHIAT, V25, P1446
   Pani L, 2009, EXPERT OPIN DRUG DEL, V6, P319, DOI 10.1517/17425240902780158
   Papakostas GI, 2004, J CLIN PSYCHIAT, V65, P217
   Parks CL, 1998, P NATL ACAD SCI USA, V95, P10734, DOI 10.1073/pnas.95.18.10734
   Pramyothin P, 2010, CURR OPIN ENDOCRINOL, V17, P460, DOI 10.1097/MED.0b013e32833de61c
   Stahl S.M., 2010, Stahls illustrated anxiety, stress, and PTSD
   Stahl SM, 2004, J CLIN PSYCHIAT, V65, P1591, DOI 10.4088/JCP.v65n1201
   Stahl SM., 2003, Prim Care Companion J Clin Psychiatry, V5, P9
   Stahl SM., 2013, Stahl's essential psychopharmacology : neuroscientific basis and practical application, V4th
   Tarsy D, 2002, CNS DRUGS, V16, P23, DOI 10.2165/00023210-200216010-00003
   *WYETH PHARM INC, 2010, EFF VENL HYDR
   Yoshimura R, 2010, PROG NEURO-PSYCHOPH, V34, P308, DOI 10.1016/j.pnpbp.2009.12.003
NR 45
TC 3
Z9 3
U1 0
U2 7
PU PROUS SCIENCE, SAU-THOMSON REUTERS
PI BARCELONA
PA 398 PROVENCA, 08025 BARCELONA, SPAIN
SN 1699-3993
EI 1699-4019
J9 DRUG TODAY
JI Drugs Today
PD APR
PY 2012
VL 48
IS 4
BP 283
EP 292
DI 10.1358/dot.2012.48.4.1745225
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 959GY
UT WOS:000305302100004
PM 22536570
DA 2025-06-11
ER

PT J
AU Kim, CJ
   Schlenk, EA
   Kang, SW
   Park, JB
AF Kim, Chun-Ja
   Schlenk, Elizabeth A.
   Kang, Se-Won
   Park, Jae-Bum
TI Effects of an internet-based lifestyle intervention on cardio-metabolic
   risks and stress in Korean workers with metabolic syndrome: A controlled
   trial
SO PATIENT EDUCATION AND COUNSELING
LA English
DT Article
DE Metabolic syndrome X; Cardio-metabolic risk; Stress; Physical activity;
   Behavioral research
ID OVERWEIGHT WORKING POPULATION; CARDIOVASCULAR-DISEASE RISK; WEB-BASED
   INTERVENTIONS; BEHAVIOR-CHANGE; HEALTH; PREVALENCE; WORKPLACE; PROGRAM;
   MANAGEMENT; REDUCTION
AB Objective: This study examined the effects of an Internet-based Best Exerciser Super Trainer (BEST) program on cardio-metabolic risks and stress among workers with metabolic syndrome.
   Methods: This study utilized a non-randomized, pretest, and posttest, controlled design with a convenience sample of 48 Korean male workers. The workers in the BEST group participated in a 16-week Internet-based program: 150 min of regular physical activity per week, 200- to 300-kcal reduced daily diet for weight control, one-on-one counseling, and mobile phone text messages. Workers in the Education group received text messages and an educational booklet.
   Results: There were significant group by time interactions in cardio-metabolic risks: body weight (p = .022), visceral fat mass (p = .033), and waist circumference (p = .037). There was no group by time interaction in stress (p >. 05); however, the BEST group showed a significantly greater reduction in health-related stress than those in the Education group (p = .025).
   Conclusion: This study yielded evidence of the beneficial impact of the Internet-based BEST program for workers with metabolic syndrome on selected cardio-metabolic risks and health-related stress. Practice implications: Internet-based one-on-one counseling and mobile phone text messages can assist individuals with targeted lifestyle modifications for metabolic syndrome. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Kim, Chun-Ja] Ajou Univ, Coll Nursing, Dept Adult Hlth Nursing, Suwon 443721, South Korea.
   [Schlenk, Elizabeth A.] Univ Pittsburgh, Sch Nursing, Pittsburgh, PA 15261 USA.
   [Kang, Se-Won] Dong Eui Univ, Coll Nursing & Healthcare Sci, Pusan, South Korea.
   [Park, Jae-Bum] Ajou Univ, Coll Nursing, Dept Occupat & Environm Med, Suwon 443721, South Korea.
C3 Ajou University; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Dong-Eui University; Ajou University
RP Kim, CJ (corresponding author), Ajou Univ, Coll Nursing, NB 213,San 5, Suwon 443721, South Korea.
EM ckimha@ajou.ac.kr
RI Kim, Chun-Ja/HKF-2429-2023
OI KIM, Chun-Ja/0000-0002-7594-5418; Schlenk, Elizabeth/0000-0001-7361-1951
FU Basic Science Research Program of the National Research Foundation of
   Korea (NRF); Korean Ministry of Education, Science and Technology (MEST)
   [20100015339]; Department of Nursing, Graduate School, Ajou University
FX This research was supported by the Basic Science Research Program of the
   National Research Foundation of Korea (NRF), which is funded by the
   Korean Ministry of Education, Science and Technology (MEST; grant number
   20100015339) and Was partly supported by a grant in 2012 from Department
   of Nursing, Graduate School, Ajou University.
CR Allen JC, 2012, PREV CHRONIC DIS, V9, DOI 10.5888/pcd9.110169
   [Anonymous], 2010, Diabetes Care, V33 Suppl 1, pS3, DOI 10.2337/dc10-S003
   [Anonymous], MAN MAJ CHRON DIS 20
   [Anonymous], EVALUATING CLIN PUBL
   [Anonymous], OBES REV
   [Anonymous], HYPOTHESIZED MODEL S
   [Anonymous], 2006, The IDF Consensus Worldwide Definition of the Metabolic Syndrome
   Bauer S, 2010, PATIENT EDUC COUNS, V79, P315, DOI 10.1016/j.pec.2010.03.014
   Bennett JB, 2011, J OCCUP ENVIRON MED, V53, P911, DOI 10.1097/JOM.0b013e3182258bd8
   Capizzi JA, 2010, PHYSICIAN SPORTSMED, V38, P45, DOI 10.3810/psm.2010.04.1761
   Chang Sei-Jin, 2005, Annals of Occupational and Environmental Medicine, V17, P297
   Cho JH, 2009, J TELEMED TELECARE, V15, P77, DOI 10.1258/jtt.2008.080412
   Choi ES, 2009, J KOREAN ACAD NURS, V39, P549, DOI 10.4040/jkan.2009.39.4.549
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Colkesen EB, 2011, VASC HEALTH RISK MAN, V7, P67, DOI 10.2147/VHRM.S16340
   Colkesen EB, 2011, J OCCUP MED TOXICOL, V6, DOI 10.1186/1745-6673-6-5
   D'Agostino RB, 2008, CIRCULATION, V117, P743, DOI 10.1161/CIRCULATIONAHA.107.699579
   Davila EP, 2010, DIABETES CARE, V33, P2390, DOI 10.2337/dc10-0681
   Dekkers JC, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-49
   Diène E, 2012, ARCH CARDIOVASC DIS, V105, P33, DOI 10.1016/j.acvd.2011.10.001
   Faul F, 2009, BEHAV RES METHODS, V41, P1149, DOI 10.3758/BRM.41.4.1149
   Ferrario M M, 2012, G Ital Med Lav Ergon, V34, P166
   Fjeldsoe BS, 2009, AM J PREV MED, V36, P165, DOI 10.1016/j.amepre.2008.09.040
   FOLKMAN S, 1986, J PERS SOC PSYCHOL, V50, P571, DOI 10.1037/0022-3514.50.3.571
   Ford ES, 2010, J DIABETES, V2, P180, DOI 10.1111/j.1753-0407.2010.00078.x
   Groeneveld IF, 2010, SCAND J WORK ENV HEA, V36, P202, DOI 10.5271/sjweh.2891
   Grundy SM, 2012, J AM COLL CARDIOL, V59, P635, DOI 10.1016/j.jacc.2011.08.080
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Jensen MD, 2014, JAMA-J AM MED ASSOC, V311, P23, DOI 10.1001/jama.2013.282546
   Jung H, 2012, J TELEMED TELECARE, V18, P339, DOI 10.1258/jtt.2012.120318
   Kang DR, 2013, IND HEALTH, V51, P256, DOI 10.2486/indhealth.2012-0044
   Kawada T, 2009, METAB SYNDR RELAT D, V7, P435, DOI 10.1089/met.2008.0087
   Kim CJ, 2013, CIN-COMPUT INFORM NU, V31, P157, DOI 10.1097/NXN.0b013e3182812829
   Kim CJ, 2011, J CARDIOVASC NURS, V26, P117, DOI 10.1097/JCN.0b013e3181ec02ae
   Knowler William C, 2002, N Engl J Med, V346, P393, DOI 10.1056/NEJMoa012512
   Kushner RF, 2014, JAMA-J AM MED ASSOC, V312, P943, DOI 10.1001/jama.2014.10432
   Lang TA, 2006, How to Report Statistics in Medicine: Annotated Guidelines For Authors Editors and Reviewers, V2nd
   Liebreich T, 2009, INT J BEHAV NUTR PHY, V6, DOI 10.1186/1479-5868-6-18
   Lim S, 2011, DIABETES CARE, V34, P1323, DOI 10.2337/dc10-2109
   MACNAIR RR, 1992, J RES PERS, V26, P150, DOI 10.1016/0092-6566(92)90051-5
   MARCUS BH, 1994, MED SCI SPORT EXER, V26, P1400
   Mastellos N, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008066.pub3
   Moher D, 2010, BMJ-BRIT MED J, V340, DOI [10.1016/j.jclinepi.2010.02.005, 10.1136/bmj.c869, 10.1186/1741-7015-8-18, 10.1016/j.ijsu.2011.10.001, 10.1136/bmj.c332, 10.4103/0976-500X.72352, 10.1186/1745-6215-11-32, 10.1016/j.jclinepi.2010.03.004]
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Neve M, 2010, OBES REV, V11, P306, DOI 10.1111/j.1467-789X.2009.00646.x
   Park MJ, 2009, INT J MED INFORM, V78, P704, DOI 10.1016/j.ijmedinf.2009.06.004
   Pedersen MT, 2009, J OCCUP ENVIRON MED, V51, P759, DOI 10.1097/JOM.0b013e3181a8663a
   Pickering Thomas G, 2005, J Clin Hypertens (Greenwich), V7, P102, DOI 10.1111/j.1524-6175.2005.04377.x
   Prochaska JO., 1994, Advances in Exercise Adherence, P161
   Racette SB, 2009, PREV MED, V49, P108, DOI 10.1016/j.ypmed.2009.06.022
   Ramadas A, 2011, INT J MED INFORM, V80, P389, DOI 10.1016/j.ijmedinf.2011.02.002
   Ryu JY, 2013, ANN OCCUP ENVIRON ME, V25, DOI 10.1186/2052-4374-25-13
   Schultz AB, 2010, VALUE HEALTH, V13, P258, DOI 10.1111/j.1524-4733.2009.00651.x
   Steptoe A, 2013, ANNU REV PUBL HEALTH, V34, P337, DOI 10.1146/annurev-publhealth-031912-114452
   Thabit H, 2013, DIABETES VASC DIS RE, V10, P337, DOI 10.1177/1479164113479808
   Thomas C, 2010, INT J EPIDEMIOL, V39, P812, DOI 10.1093/ije/dyp365
   Thorndike AN, 2012, AM J PREV MED, V43, P27, DOI 10.1016/j.amepre.2012.02.029
   van Wier MF, 2006, BMC PUBLIC HEALTH, V6, DOI 10.1186/1471-2458-6-140
   World Health Organization, 2007, Prevention of Cardiovascular Disease: Guidelines for Assessment and Management of Total Cardiovascular Risk
   Yamaoka K, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-138
NR 60
TC 14
Z9 17
U1 0
U2 16
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0738-3991
EI 1873-5134
J9 PATIENT EDUC COUNS
JI Patient Educ. Couns.
PD JAN
PY 2015
VL 98
IS 1
BP 111
EP 119
DI 10.1016/j.pec.2014.10.013
PG 9
WC Public, Environmental & Occupational Health; Social Sciences,
   Interdisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Social Sciences - Other
   Topics
GA AX5FO
UT WOS:000346952400015
PM 25468401
DA 2025-06-11
ER

PT J
AU Vitale, E
AF Vitale, Elsa
TI A Chronic Inflammatory Inductive Condition in the Nursing Profession: A
   Scoping Review
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Review
DE Body mass index; diet; inflammation; mental health; physical activity;
   nurses
ID BODY-MASS INDEX; TIME PHYSICAL-ACTIVITY; C-REACTIVE PROTEIN;
   ADIPOSE-TISSUE; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; DEPRESSIVE
   SYMPTOMS; INSULIN-RESISTANCE; ANXIETY DISORDERS; OXIDATIVE STRESS
AB Background Literature focuses on the well-being of patients and little on the well-being of nurses who, in turn, should be educated about well-being. On the other hand, the latter often work under serious pressure with inadequate resources and shift organizations, exposing them to health risk factors. Objective To highlight which relationships exist between diet, physical activity, body mass index (BMI) and mental health in nursing. Methods The author searched the Medline (PubMed) database for medical subheadings terms and free full text referred to "Diet," "Mental Health," "Physical Activity," and "Nurses" before 31st December 2020. Results A total of 11 studies were included in this perspective review, which better defined the relationships between diet, physical activity, mental health and the nursing profession. Conclusion From the studies present in the literature, it emerges that the nursing profession has an inherent imbalance in the regular circadian activity of human nature, as nursing assistance is provided 24 hours a day and during the night. Numerous studies have highlighted significant differences between mental and eating disorder levels among nurses who work at night versus those who only work during the day. Therefore, it is possible to speak of the nursing profession as an "inductive inflammatory-chronic" activity based on the extensive scientific evidence provided by the literature.
C1 [Vitale, Elsa] Ctr Mental Hlth Modugno, Local Hlth Author Bari, Bari, Italy.
   [Vitale, Elsa] Via X Marzo 43, I-70026 Bari, Italy.
RP Vitale, E (corresponding author), Ctr Mental Hlth Modugno, Local Hlth Author Bari, Bari, Italy.; Vitale, E (corresponding author), Via X Marzo 43, I-70026 Bari, Italy.
EM vitaleelsa@libero.it
RI Vitale, Elsa/D-8904-2018
OI Vitale, Elsa/0000-0002-9738-3479
CR Abbasi NH, 2020, AM J MENS HEALTH, V14, DOI 10.1177/1557988320966519
   Abdi S., 2019, Rooyesh Ravanshenasi J, V11, P1
   Ahima RS, 2014, MOL ENDOCRINOL, V28, P785, DOI 10.1210/me.2014-1140
   Al-Yateem N, 2018, INT J MENT HEALTH SY, V12, DOI 10.1186/s13033-018-0184-4
   Allison MB, 2014, J ENDOCRINOL, V223, pT25, DOI 10.1530/JOE-14-0404
   Arnett DK, 2019, CIRCULATION, V140, pE563, DOI [10.1016/j.jacc.2019.03.009, 10.1016/j.jacc.2019.03.010, 10.1161/CIR.0000000000000678, 10.1161/CIR.0000000000000677]
   Attie AD, 2009, J LIPID RES, V50, pS395, DOI 10.1194/jlr.R800057-JLR200
   Bakhtiari Afsaneh, 2018, Iran J Psychiatry, V13, P230
   Bao Y, 2016, AM J PUBLIC HEALTH, V106, P1573, DOI 10.2105/AJPH.2016.303338
   Beijers L, 2019, PSYCHOL MED, V49, P617, DOI 10.1017/S0033291718001307
   Bertoia ML, 2016, BMJ-BRIT MED J, V352, DOI 10.1136/bmj.i17
   Beydoun MA, 2010, J AFFECT DISORDERS, V123, P52, DOI 10.1016/j.jad.2009.09.021
   Bhatti MA, 2018, INT J HEALTH CARE Q, V31, P1000, DOI 10.1108/IJHCQA-07-2017-0129
   Brites F, 2017, BBA CLIN, V8, P66, DOI 10.1016/j.bbacli.2017.07.002
   Bulut M, 2013, J AFFECT DISORDERS, V150, P829, DOI 10.1016/j.jad.2013.03.011
   Byrne Gerard JA, 2002, Braz. J. Psychiatry, V24, P74, DOI 10.1590/S1516-44462002000500014
   Ceylan MF, 2014, REDOX REP, V19, P92, DOI 10.1179/1351000213Y.0000000082
   Cheung T, 2016, INT J ENV RES PUB HE, V13, DOI 10.3390/ijerph13010135
   Chin DL, 2016, INT J NURS STUD, V57, P60, DOI 10.1016/j.ijnurstu.2016.01.009
   Cho H, 2018, J NURS SCHOLARSHIP, V50, P403, DOI 10.1111/jnu.12390
   Cildir G, 2013, TRENDS MOL MED, V19, P487, DOI 10.1016/j.molmed.2013.05.001
   Clancy A, 2007, INT NURS REV, V54, P197, DOI 10.1111/j.1466-7657.2007.00519.x
   Cuijpers P, 2002, J AFFECT DISORDERS, V72, P227, DOI 10.1016/S0165-0327(01)00413-X
   Cummins TD, 2014, AM J PHYSIOL-ENDOC M, V307, pE262, DOI 10.1152/ajpendo.00271.2013
   Curtis JM, 2010, DIABETES, V59, P1132, DOI 10.2337/db09-1105
   Denes V, 2019, J CLIN MED, V8, DOI 10.3390/jcm8091488
   Dias CH, 2020, WORKPLACE HEALTH SAF, V68, P374, DOI 10.1177/2165079919890351
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Eckel N, 2018, LANCET DIABETES ENDO, V6, P714, DOI 10.1016/S2213-8587(18)30137-2
   Eilat-Adar S, 2013, NUTRIENTS, V5, P3646, DOI 10.3390/nu5093646
   Elbejjani M, 2020, BMC NURS, V19, DOI 10.1186/s12912-020-00485-z
   Fathabadi J., 2019, J HLTH ED HLTH PROMO, V5, P280, DOI [10.30699/acadpub.ijhehp.5.4.280, DOI 10.30699/ACADPUB.IJHEHP.5.4.280]
   Flegal KM, 2013, JAMA-J AM MED ASSOC, V309, P71, DOI 10.1001/jama.2012.113905
   Forejt M, 2017, CENT EUR J PUBL HEAL, V25, P321, DOI 10.21101/cejph.a4451
   Fransson EI, 2012, AM J EPIDEMIOL, V176, P1078, DOI 10.1093/aje/kws336
   Galderisi S, 2015, WORLD PSYCHIATRY, V14, P231, DOI 10.1002/wps.20231
   Gallegos-Carrillo K, 2013, HEALTH PSYCHOL, V32, P609, DOI 10.1037/a0029276
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Gorin AA, 2004, INT J OBESITY, V28, P278, DOI 10.1038/sj.ijo.0802550
   Hao YZ, 2020, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.507969
   Hill M, 2016, HORM MOL BIOL CLIN I, V26, P153, DOI 10.1515/hmbci-2016-0002
   Hong KJ, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17197068
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Humer E, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21134784
   Jirillo E, 2015, ANN NUTR METAB, V67, P42
   Jordan TR, 2016, NURS RES PRACT, V2016, DOI 10.1155/2016/5843256
   Jung G, 2020, HEALTHCARE-BASEL, V8, DOI 10.3390/healthcare8040490
   Kahleova H, 2017, J NUTR, V147, P1722, DOI 10.3945/jn.116.244749
   Khanal P, 2020, GLOBALIZATION HEALTH, V16, DOI 10.1186/s12992-020-00621-z
   Kim O, 2017, J WOMENS HEALTH, V26, P892, DOI 10.1089/jwh.2016.6048
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178, DOI 10.4088/JCP.v69n0202
   Krueger JM, 2008, CURR PHARM DESIGN, V14, P3408, DOI 10.2174/138161208786549281
   Lai JS, 2017, EUR J NUTR, V56, P273, DOI 10.1007/s00394-015-1078-8
   Lallukka T, 2008, SOC SCI MED, V66, P1681, DOI 10.1016/j.socscimed.2007.12.027
   Lee YS, 2014, CELL, V157, P1339, DOI 10.1016/j.cell.2014.05.012
   Letvak Susan, 2013, Nurs Adm Q, V37, P295, DOI 10.1097/NAQ.0b013e3182a2f99a
   Letvak SA, 2012, AM J NURS, V112, P30, DOI 10.1097/01.NAJ.0000411176.15696.f9
   Loas G, 2016, PSYCHIAT RES, V246, P296, DOI 10.1016/j.psychres.2016.09.056
   Lumeng CN, 2011, J CLIN INVEST, V121, P2111, DOI 10.1172/JCI57132
   Maeng LY, 2015, HORM BEHAV, V76, P106, DOI 10.1016/j.yhbeh.2015.04.002
   Marx W, 2021, MOL PSYCHIATR, V26, P134, DOI 10.1038/s41380-020-00925-x
   McNaughton N, 2013, J AFFECT DISORDERS, V148, P104, DOI 10.1016/j.jad.2012.11.057
   Meegan AP, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030238
   Michopoulos V, 2017, NEUROPSYCHOPHARMACOL, V42, P254, DOI 10.1038/npp.2016.146
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Mokhtari R, 2020, INT J MENT HEALTH NU, V29, P1275, DOI 10.1111/inm.12800
   Moreira EG, 2019, CURR NEUROPHARMACOL, V17, P1004, DOI 10.2174/1570159X17666181227164947
   Mosca L, 2011, J AM COLL CARDIOL, V57, P1404, DOI [10.1016/j.jacc.2011.02.005, 10.1161/CIR.0b013e31820faaf8]
   Mostofsky E, 2016, AM J PUBLIC HEALTH, V106, P1586, DOI 10.2105/AJPH.2016.303336
   Moussavi S, 2007, LANCET, V370, P851, DOI 10.1016/S0140-6736(07)61415-9
   Mozumdar A, 2011, DIABETES CARE, V34, P216, DOI 10.2337/dc10-0879
   Navidian A., 2010, J BEHAV SCI, V4, P149
   Neo PSH, 2011, COGN AFFECT BEHAV NE, V11, P485, DOI 10.3758/s13415-011-0046-x
   Odegaard JI, 2013, SCIENCE, V339, P172, DOI 10.1126/science.1230721
   Ouchi N, 2011, NAT REV IMMUNOL, V11, P85, DOI 10.1038/nri2921
   Pappa S, 2020, BRAIN BEHAV IMMUN, V88, P901, DOI [10.1016/j.bbi.2020.11.023, 10.1016/j.bbi.2020.05.026]
   Pasarica M, 2009, DIABETES, V58, P718, DOI 10.2337/db08-1098
   Peipins LA, 1997, AM J PUBLIC HEALTH, V87, P1539, DOI 10.2105/AJPH.87.9.1539
   Perry L, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15050945
   Perry L, 2017, J ADV NURS, V73, P2745, DOI 10.1111/jan.13347
   Pontiroli AE, 2011, ANN SURG, V253, P484, DOI 10.1097/SLA.0b013e31820d98cb
   Power Brian T, 2017, BMC Obes, V4, P18, DOI 10.1186/s40608-017-0154-4
   Reed JL, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00142
   Rethorst CD, 2014, J CLIN PSYCHIAT, V75, pE1428, DOI 10.4088/JCP.14m09009
   Richards JR, 2018, CLIN EXP EMERG MED, V5, P240
   Rosenbaum DL, 2016, CLIN OBES, V6, P193, DOI 10.1111/cob.12142
   Roskoden FC, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0169983
   Ross RA, 2020, NEUROPSYCHOPHARMACOL, V45, P1125, DOI 10.1038/s41386-020-0604-4
   Rothschild J, 2014, NUTR REV, V72, P308, DOI 10.1111/nure.12104
   Ruel S, 2020, HEALTH PSYCHOL, V39, P358, DOI 10.1037/hea0000811
   Savard J, 2003, PSYCHOSOM MED, V65, P211, DOI 10.1097/01.PSY.0000033126.22740.F3
   Savic M, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16203821
   Scheers T, 2013, MED SCI SPORT EXER, V45, P481, DOI 10.1249/MSS.0b013e31827563ba
   Shadli SM, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.188
   Shields M., 2006, Findings from the 2005 national survey on the work and health of nurses
   Slewa-Younan S, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/s12888-014-0320-x
   Sobel M.E., 1984, SOC FORCES, V62, P1121, DOI [10.2307/2578587, DOI 10.2307/2578587]
   Braga VAS, 2017, REV ESC ENFERM USP, V51, DOI [10.1590/s1980-220x2017019203293, 10.1590/S1980-220X2017019203293]
   Stanulewicz N, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17010017
   Steel Z, 2014, INT J EPIDEMIOL, V43, P476, DOI 10.1093/ije/dyu038
   Stelekati E, 2012, CELL HOST MICROBE, V12, P458, DOI 10.1016/j.chom.2012.10.001
   Suzuki K, 2004, J OCCUP HEALTH, V46, P448, DOI 10.1539/joh.46.448
   Swarbrick M.A., 1997, MENTAL HLTH SPEC INT, V20, P1
   Tanaka K, 2010, IND HEALTH, V48, P775, DOI 10.2486/indhealth.MS1151
   Tassielli Concetta, 2012, Prof Inferm, V65, P25
   Terada T, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092054
   Thomsen DK, 2004, PSYCHOSOM MED, V66, P363, DOI 10.1097/01.psy.0000127688.44363.fb
   Torres ER, 2013, PREV MED, V56, P410, DOI 10.1016/j.ypmed.2013.02.013
   Travers RL, 2015, INT J OBESITY, V39, P762, DOI 10.1038/ijo.2014.195
   Vitale E., 2014, CLIN IMMUNOL ENDOCR, V1, P81, DOI [10.2174/2212707002666150402225920, DOI 10.2174/2212707002666150402225920]
   Vitale E, 2022, ENDOCR METAB IMMUNE, V22, P490, DOI 10.2174/1871530321666210715125939
   Vitale E, 2021, J EVID-BASED PSYCHOT, V21, P83
   Vitale Elsa, 2021, Acta Biomed, V92, pe2021007, DOI 10.23750/abm.v92iS2.11305
   Vitale E, 2020, MINERVA PSICH, V61, P162, DOI 10.23736/S0391-1772.20.02090-7
   Vitale Elsa, 2020, Acta Biomed, V91, pe2020117, DOI 10.23750/abm.v91i4.9008
   Vitale Elsa, 2020, Acta Biomed, V91, pe2020007, DOI 10.23750/abm.v91i12-S.9860
   Vitale E, 2021, ENDOCR METAB IMMUNE, V21, P1604, DOI 10.2174/1871530320666201016150033
   Vitale E, 2014, ENDOCR METAB IMMUNE, V14, P93, DOI 10.2174/1871530314666140307095630
   Vitale E, 2010, IMMUNOPHARM IMMUNOT, V32, P5, DOI 10.1080/08923970903104090
   Whitlock G, 2009, LANCET, V373, P1083, DOI 10.1016/S0140-6736(09)60318-4
   Xianyu Yunyan, 2006, Nurs Health Sci, V8, P147, DOI 10.1111/j.1442-2018.2006.00281.x
   Yoshizaki T, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2016-011987
   Zangirolami-Raimundo J, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000014213
   Zeyda M, 2011, OBESITY, V19, P743, DOI 10.1038/oby.2010.123
   Zoeller RF, 2007, AM J LIFESTYLE MED, V1, P175, DOI 10.1177/1559827607300518
NR 125
TC 3
Z9 3
U1 2
U2 6
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2022
VL 22
IS 13
BP 1235
EP 1244
DI 10.2174/1871530322666220516163936
PG 10
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA 7A9MU
UT WOS:000898771900002
PM 35578870
DA 2025-06-11
ER

PT J
AU Dent, KR
   Brennan, GM
   Khalifeh, L
   Richmond-Rakerd, LS
AF Dent, Kallisse R.
   Brennan, Grace M.
   Khalifeh, Lara
   Richmond-Rakerd, Leah S.
TI Midlife diseases of despair and cardiometabolic risk: testing shared
   origins in adolescent psychopathology
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE adolesecent psychopathology; cardiometabolic risk; diseases of despair;
   midlife morbidity
ID MENTAL-DISORDERS; CARDIOVASCULAR-DISEASE; LIFETIME PREVALENCE; US
   ADULTS; HEALTH; INEQUALITIES; INTELLIGENCE; MORTALITY; SYMPTOMS;
   BEHAVIOR
AB Background Rising midlife mortality in the United States is largely attributable to 'deaths of despair' (deaths from suicide, drug poisonings, and alcohol-related diseases) and deaths from cardiometabolic conditions. Although despair- and cardiometabolic-related mortality are increasing concurrently, it is unclear whether they share common developmental origins. We tested adolescent psychopathology as a potential common origin of midlife diseases of despair and cardiometabolic risk.Methods Participants (N = 4578) were from the National Longitudinal Study of Adolescent to Adult Health, a nationally representative cohort followed from adolescence to early midlife. Adolescent psychopathology included depression, anxiety, eating disorders, PTSD, conduct disorder, and ADHD at ages 11-18. Diseases of despair (suicidality, substance misuse, pain, and sleep problems) and cardiometabolic risk (hypertension, hyperlipidemia, high-risk waist circumference, diabetes, and cardiovascular conditions) were multi-modally measured at ages 33-43.Results At midlife, adolescents who experienced psychopathology exhibited more indicators of despair-related diseases and cardiometabolic risk (IRRs = 1.67 [1.46-1.87] and 1.13 [1.04-1.21], respectively), even after accounting for demographics, adolescent SES, and adolescent cognitive ability. Associations were evident for internalizing and externalizing conditions, and in a dose-response fashion. In mediation analyses, low education explained little of these associations, but early-adult substance use explained 21.5% of psychopathology's association with despair-related diseases. Midlife despair-related diseases and cardiometabolic risk co-occurred within individuals (IRR = 1.12 [1.08-1.16]). Adolescent psychopathology accounted for 8.3% of this co-occurrence, and 16.7% together with adolescent SES and cognitive ability.Conclusions Adolescent psychopathology precedes both diseases of despair and cardiometabolic risk. Prevention and treatment of psychopathology may mitigate multiple causes of poor midlife health, reducing premature mortality.
C1 [Dent, Kallisse R.; Khalifeh, Lara; Richmond-Rakerd, Leah S.] Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA.
   [Brennan, Grace M.] Duke Univ, Dept Psychol & Neurosci, Durham, NC USA.
   [Brennan, Grace M.] Duke Univ, Duke Aging Ctr, Sch Med, Durham, NC USA.
C3 University of Michigan System; University of Michigan; Duke University;
   Duke University
RP Dent, KR (corresponding author), Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA.
EM dentkr@umich.edu
RI Brennan, Grace/S-9042-2019
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development (NICHD) [P01 HD31921]; National Institute on Aging (NIA) at
   the University of North Carolina at Chapel Hill [U01 AG071448,
   U01AG071450]; American Foundation for Suicide Prevention (LSR-R)
   [PRG-1-153-20]; NIA (KRD) [T32AG027708]; Duke Aging Center Postdoctoral
   Research Training Grant (GMB) [T32AG000029]
FX This research uses data from Add Health, funded by grant P01 HD31921
   (Harris) from the Eunice Kennedy Shriver National Institute of Child
   Health and Human Development (NICHD), with cooperative funding from 23
   other federal agencies and foundations. Add Health is currently directed
   by Robert A. Hummer and funded by the National Institute on Aging (NIA)
   cooperative agreements U01 AG071448 (Hummer)and U01AG071450 (Aiello and
   Hummer) at the University of North Carolina at Chapel Hill. Add Health
   was designed by J. Richard Udry, PeterS. Bearman, and Kathleen Mullan
   Harris at the University of North Carolina at Chapel Hill. Additional
   support was provided from the American Foundation for Suicide Prevention
   (LSR-R, PRG-1-153-20), the NIA (KRD, T32AG027708, PIs: Kobayashi and
   Park), and the Duke Aging Center Postdoctoral Research Training Grant
   (GMB, T32AG000029). This work's content is solely the responsibility of
   the authors and does not necessarily represent the official views of the
   funding agencies.
CR Abdul-Rahman AK, 2018, SUBST ABUS, V39, P509, DOI 10.1080/08897077.2018.1475318
   Ames ME, 2018, HEALTH PSYCHOL, V37, P103, DOI 10.1037/hea0000560
   [Anonymous], 2016, SAS 94 LANGUAGE REFE, VSixth
   [Anonymous], 2022, Global roadmap for healthy longevity, DOI DOI 10.17226/26144
   Beccuti G, 2011, CURR OPIN CLIN NUTR, V14, P402, DOI 10.1097/MCO.0b013e3283479109
   Beseran E, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph191912395
   Blodgett JM, 2021, BMC PSYCHIATRY, V21, DOI 10.1186/s12888-021-03206-1
   Boehm JK, 2022, PSYCHOL SCI, V33, P1199, DOI 10.1177/09567976221075608
   Bourassa KJ, 2022, JAMA PEDIATR, V176, P392, DOI 10.1001/jamapediatrics.2021.6417
   Brennan GM, 2023, PSYCHOL MED, V53, P7569, DOI 10.1017/S0033291723001320
   Case A, 2022, ANNU REV ECON, V14, P1, DOI 10.1146/annurev-economics-051520-015607
   Case A, 2015, P NATL ACAD SCI USA, V112, P15078, DOI 10.1073/pnas.1518393112
   Caspi A, 2014, CLIN PSYCHOL SCI, V2, P119, DOI 10.1177/2167702613497473
   Copeland WE, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.8627
   Copeland WE, 2015, JAMA PSYCHIAT, V72, P892, DOI 10.1001/jamapsychiatry.2015.0730
   De G, 2024, INT J CONSUM STUD, V48, DOI 10.1111/ijcs.13000
   Deste G, 2023, FRONT PSYCHIATRY, V14, DOI 10.3389/fpsyt.2023.1174055
   Di Angelantonio E, 2015, JAMA-J AM MED ASSOC, V314, P52, DOI 10.1001/jama.2015.7008
   Donato KA, 1998, ARCH INTERN MED, V158, P1855, DOI 10.1001/archinte.158.17.1855
   Drozdz D, 2021, NUTRIENTS, V13, DOI 10.3390/nu13114176
   Fayaz A, 2016, SCAND J PAIN, V13, P76, DOI 10.1016/j.sjpain.2016.06.005
   Gan WQ, 2021, DRUG ALCOHOL DEPEN, V229, DOI 10.1016/j.drugalcdep.2021.109132
   Gaydosh L, 2019, AM J PUBLIC HEALTH, V109, P774, DOI 10.2105/AJPH.2019.305002
   Ge L, 2019, SLEEP MED REV, V48, DOI 10.1016/j.smrv.2019.101215
   Glei DA, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0226732
   Goldstein BI, 2020, CAN J CARDIOL, V36, P1394, DOI 10.1016/j.cjca.2020.06.023
   Gottfredson LS, 2004, J PERS SOC PSYCHOL, V86, P174, DOI 10.1037/0022-3514.86.1.174
   Harris K.M., 2021, High and Rising Mortality Rates Among Working-Age Adults, DOI [DOI 10.17226/25976, 10.17226/25976 10.17226/25976]
   Harris KM, 2022, ANNU REV DEV PSYCHOL, V4, P297, DOI 10.1146/annurev-devpsych-120920-023842
   Harris KM, 2019, INT J EPIDEMIOL, V48, P1415, DOI 10.1093/ije/dyz115
   Hoare E, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.11381
   Huyett P, 2021, LARYNGOSCOPE, V131, P686, DOI 10.1002/lary.28900
   Inoue K, 2022, EPIDEMIOLOGY, V33, P572, DOI 10.1097/EDE.0000000000001490
   Jaffee SR, 2005, J AM ACAD CHILD PSY, V44, P406, DOI 10.1097/01.chi.0000155317.38265.61
   Kessler RC, 2001, BIOL PSYCHIAT, V49, P1002, DOI 10.1016/S0006-3223(01)01129-5
   Lachman ME, 2015, INT J BEHAV DEV, V39, P20, DOI 10.1177/0165025414533223
   Merikangas KR, 2010, J AM ACAD CHILD PSY, V49, P980, DOI 10.1016/j.jaac.2010.05.017
   Michal M, 2021, HEART, V107, P1756, DOI 10.1136/heartjnl-2019-316379
   Miles DR, 2002, AM J MED GENET, V114, P159, DOI 10.1002/ajmg.10178
   Moffitt TE, 2010, PSYCHOL MED, V40, P899, DOI 10.1017/S0033291709991036
   Montano D, 2022, BMC CARDIOVASC DISOR, V22, DOI 10.1186/s12872-022-02681-y
   Moore DM, 2023, J INTELL-BASEL, V11, DOI 10.3390/jintelligence11050090
   Moreno-Agostino D, 2021, J AFFECT DISORDERS, V281, P235, DOI 10.1016/j.jad.2020.12.035
   Muthen L. K., 1998, Mplus user guide, V6th ed
   O'Hearn M, 2022, J AM COLL CARDIOL, V80, P138, DOI 10.1016/j.jacc.2022.04.046
   Patton GC, 2016, LANCET, V387, P2423, DOI 10.1016/S0140-6736(16)00579-1
   Phelan JC, 2004, J HEALTH SOC BEHAV, V45, P265, DOI 10.1177/002214650404500303
   Ploubidis GB, 2021, JAMA PSYCHIAT, V78, P38, DOI 10.1001/jamapsychiatry.2020.2893
   Prabhakar D, 2021, CRISIS, V42, P343, DOI 10.1027/0227-5910/a000729
   Raudsepp L, 2016, EUR J SPORT SCI, V16, P1153, DOI 10.1080/17461391.2016.1174312
   Richmond-Rakerd LS, 2021, P NATL ACAD SCI USA, V118, DOI 10.1073/pnas.2010211118
   ROBERTS RE, 1991, J AM ACAD CHILD PSY, V30, P58, DOI 10.1097/00004583-199101000-00009
   Shah NS, 2020, J AM HEART ASSOC, V9, DOI 10.1161/JAHA.120.018213
   Sterling P, 2022, JAMA PSYCHIAT, V79, P368, DOI 10.1001/jamapsychiatry.2021.4209
   Storr CL, 2012, PUBLIC HEALTH REV, V34, DOI 10.1007/BF03391678
   Vgontzas AN, 1998, ARCH INTERN MED, V158, P1333, DOI 10.1001/archinte.158.12.1333
   WALLBROWN FH, 1975, J PSYCHOL, V89, P223, DOI 10.1080/00223980.1975.9915755
   Wang T, 2024, J PUBLIC HEALTH-HEID, V32, P385, DOI 10.1007/s10389-023-01825-4
   Wang YY, 2023, HYPERTENSION, V80, P192, DOI 10.1161/HYPERTENSIONAHA.122.20286
   Woolf SH, 2019, JAMA-J AM MED ASSOC, V322, P1996, DOI 10.1001/jama.2019.16932
NR 60
TC 1
Z9 1
U1 2
U2 4
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD AUG
PY 2024
VL 54
IS 11
BP 2866
EP 2875
DI 10.1017/S0033291724000916
EA APR 2024
PG 10
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA R7C2F
UT WOS:001202788800001
PM 38618989
OA hybrid
DA 2025-06-11
ER

PT J
AU Ishino, FAM
   Canenguez, KM
   Cohen, JH
   Kent, BV
   Villalobos, K
   Needham, BL
   Kandula, NR
   Kanaya, AM
   Shields, AE
   Williams, F
AF Montiel Ishino, Francisco A.
   Canenguez, Katia M.
   Cohen, Jeffrey H.
   Kent, Blake Victor
   Villalobos, Kevin
   Needham, Belinda L.
   Kandula, Namratha R.
   Kanaya, Alka M.
   Shields, Alexandra E.
   Williams, Faustine
TI Profiles of cardiometabolic risk and acculturation indicators among
   South Asians in the US: latent class analysis of the MASALA study
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE cardiometabolic disease; South Asian; latent class analysis; social
   determinants of health; acculturation
ID DIETARY PATTERNS; MENTAL-HEALTH; UNITED-STATES; INDIANS; DISCRIMINATION;
   IMMIGRANTS; ATHEROSCLEROSIS; ASSOCIATION; PREVALENCE; MEDIATORS
AB Background South Asians (SA) represent the fastest growing US immigrant group, and previous studies have indicated that they face disproportionately high burden of cardiometabolic disease. Cardiometabolic disease manifests as a syndemic or synergistic epidemic encompassing multiple disease clusters influenced by biological, social, and psychological factors stemming from the acculturative process. This process may exacerbate morbidity within immigrant subgroups. Our aim was to identify cardiometabolic risk profiles among SA using indicators of acculturation.Methods We conducted a latent class analysis on data from the Mediators of Atherosclerosis in South Asians Living in America study (N=771). A composite cardiometabolic disease outcome was constructed using prevalent hypertension, type 2 diabetes, and body mass index. Acculturation indicators included years living in the US, English language proficiency, dietary behaviors, preservation of cultural traditions, social and neighborhood support, maintenance of social relationships (i.e., friendships), and experiences of discrimination, along with proxies of acculturative stress (i.e., depressive symptomology, trait anxiety and anger). Social and environmental determinants of health, health behaviors, religiosity and spirituality served as covariates to further assess latent class membership.Results Four cardiometabolic risk profiles emerged: (1) lowest risk [73.8% of sample] characterized by high integration into both SA and US cultures; (2) the modest risk [13.4% of sample], exhibiting elevated levels of mental health distress and experiences of discrimination, and distancing themselves from both cultures; and the (3) moderate risk [8.9% of sample] and (4) highest risk [3.9% of sample], demonstrating greater assimilation into US culture. Compared to the lowest risk profile: the modest risk profile was associated with low-income and conflicting attitudes about religion/spirituality, while the moderate risk profile was characterized by lower income and educational attainment with positive behaviors and attitudes toward religion/spirituality.Conclusion Findings expand our understanding of immigrant cardiometabolic health as a syndemic issue wherein multiple co-occurring and interacting processes synergize to produce negative outcomes in already at-risk subpopulations. Furthermore, acculturation emerges as a crucial factor in understanding health disparities among immigrant and refugee groups in the US.
C1 [Montiel Ishino, Francisco A.; Williams, Faustine] Natl Inst Minor Hlth & Hlth Dispar, Div Intramural Res, NIH, Bethesda, MD 20892 USA.
   [Montiel Ishino, Francisco A.; Villalobos, Kevin] NIEHS, Div Intramural Res, NIH, Durham, NC 27709 USA.
   [Canenguez, Katia M.; Kent, Blake Victor; Shields, Alexandra E.] Harvard Massachusetts Gen Hosp, Ctr Genom Vulnerable Populat & Hlth Dispar, Boston, MA USA.
   [Cohen, Jeffrey H.] Ohio State Univ, Dept Anthropol, Columbus, OH USA.
   [Kent, Blake Victor] Westmont Coll, Dept Sociol, Santa Barbara, CA USA.
   [Needham, Belinda L.] Univ Michigan, Dept Epidemiol, Ann Arbor, MI USA.
   [Kandula, Namratha R.] Northwestern Univ, Feinberg Sch Med, Inst Publ Hlth & Med, Ctr Community Hlth, Chicago, IL USA.
   [Kandula, Namratha R.] Northwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL USA.
   [Kanaya, Alka M.] Univ Calif San Francisco, Dept Med Epidemiol & Biostat, San Francisco, CA USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Minority Health & Health Disparities (NIMHD); Division of Intramural
   Research (DIR); National Institutes of Health (NIH) - USA; NIH National
   Institute of Environmental Health Sciences (NIEHS); Harvard University;
   Harvard University Medical Affiliates; Massachusetts General Hospital;
   University System of Ohio; Ohio State University; University of Michigan
   System; University of Michigan; Northwestern University; Feinberg School
   of Medicine; Northwestern University; Feinberg School of Medicine;
   University of California System; University of California San Francisco
RP Ishino, FAM (corresponding author), Natl Inst Minor Hlth & Hlth Dispar, Div Intramural Res, NIH, Bethesda, MD 20892 USA.; Ishino, FAM (corresponding author), NIEHS, Div Intramural Res, NIH, Durham, NC 27709 USA.
EM francisco.montielishino@nih.gov
RI Montiel Ishino, Francisco/I-2077-2016; Williams, Faustine/JCE-5252-2023
FU Division of Intramural Research; National Institute on Minority Health
   and Health Disparities [ZIA MD000015]; Division of Intramural Research
   at the National Institute on Minority Health and Health Disparities [ZIA
   MD000015]; Division of Intramural Research at the National Institute of
   Environmental Health Sciences [Z1A ES103325]; National Heart, Lung, and
   Blood Institute [R01HL093009, 2R01HL093009]; National Center for
   Research Resources; National Center for Advancing Translational
   Sciences, National Institutes of Health through University of California
   San Francisco Clinical and Translational Sciences Institute
   [UL1RR024131, UL1TR001872]; Northwestern University Clinical and
   Translational Sciences Institute [UL1TR001422]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This efforts
   of Williams were supported by the Division of Intramural Research, the
   National Institute on Minority Health and Health Disparities (ZIA
   MD000015). This efforts of Montiel Ishino and Villalobos were supported
   by the Division of Intramural Research at the National Institute on
   Minority Health and Health Disparities (ZIA MD000015) and Division of
   Intramural Research at the National Institute of Environmental Health
   Sciences (Z1A ES103325). The content was solely the responsibility of
   the authors and does not necessarily reflect the views of the National
   Institutes of Health. The MASALA study described in this work was
   supported by the National Heart, Lung, and Blood Institute (R01HL093009
   and 2R01HL093009), the National Center for Research Resources and the
   National Center for Advancing Translational Sciences, National
   Institutes of Health through University of California San Francisco
   Clinical and Translational Sciences Institute (UL1RR024131 and
   UL1TR001872), and the Northwestern University Clinical and Translational
   Sciences Institute (UL1TR001422). The use of these data does not imply
   the National Institutes of Health, University of California San
   Francisco, or Northwestern University agree or disagree with any
   presentations, analyses, interpretations, or conclusions herein, nor had
   any involvement with analyses, interpretations, conclusions, or
   manuscript development.
CR Abraído-Lanza AF, 2016, ANNU REV PUBL HEALTH, V37, P219, DOI 10.1146/annurev-publhealth-032315-021545
   Ai AL, 2010, J HEALTH PSYCHOL, V15, P186, DOI 10.1177/1359105309345556
   Al-Sofiani ME, 2020, DIABETES RES CLIN PR, V161, DOI 10.1016/j.diabres.2020.108052
   Alamilla SG, 2010, HISPANIC J BEHAV SCI, V32, P55, DOI 10.1177/0739986309352770
   ANDRESEN EM, 1994, AM J PREV MED, V10, P77, DOI 10.1016/S0749-3797(18)30622-6
   Anjana RM, 2023, LANCET DIABETES ENDO, V11, P474, DOI 10.1016/S2213-8587(23)00119-5
   Ano GG, 2005, J CLIN PSYCHOL, V61, P461, DOI 10.1002/jclp.20049
   Balidemaj A, 2019, INT J SOC PSYCHIATR, V65, P643, DOI 10.1177/0020764019867994
   Berry J., 2003, Acculturation: Advances in theory, measurement, and applied research, P17, DOI DOI 10.1037/10472-004
   Berry JW, 2009, INT J INTERCULT REL, V33, P361, DOI 10.1016/j.ijintrel.2009.06.003
   Berry JW, 2005, INT J INTERCULT REL, V29, P697, DOI 10.1016/j.ijintrel.2005.07.013
   Bharmal N, 2013, PREV MED, V57, P315, DOI 10.1016/j.ypmed.2013.06.003
   Bhupathiraju SN, 2018, J NUTR, V148, P1150, DOI 10.1093/jn/nxy074
   Carpenter TP, 2012, PSYCHOL RELIG SPIRIT, V4, P19, DOI 10.1037/a0023155
   Castañeda H, 2015, ANNU REV PUBL HEALTH, V36, P375, DOI 10.1146/annurev-publhealth-032013-182419
   Chae DH, 2020, HEALTH PSYCHOL, V39, P209, DOI 10.1037/hea0000832
   Cozier YC, 2018, ANN BEHAV MED, V52, P989, DOI 10.1093/abm/kay001
   de Oliveira R, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/s13098-015-0027-2
   Flowers E, 2019, DIABETES CARE, V42, P946, DOI 10.2337/dc18-1510
   Gadgil MD, 2020, J IMMIGR MINOR HEALT, V22, P1135, DOI 10.1007/s10903-020-01016-3
   Gadgil MD, 2015, J NUTR, V145, P1211, DOI 10.3945/jn.114.207753
   Gadgil MD, 2014, J ACAD NUTR DIET, V114, P238, DOI 10.1016/j.jand.2013.09.021
   Gill G, 2020, J OBES, V2020, DOI 10.1155/2020/7937530
   Gujral UP, 2020, BMJ OPEN DIAB RES CA, V8, DOI 10.1136/bmjdrc-2019-001063
   Hirode G, 2019, BMC CARDIOVASC DISOR, V19, DOI 10.1186/s12872-019-1045-z
   Hulten E, 2014, DIABETES CARE, V37, P555, DOI 10.2337/dc13-1431
   Johns E, 2017, CURR DIABETES REP, V17, DOI 10.1007/s11892-017-0929-5
   Joseph LM, 2015, CLIN NURS RES, V24, P188, DOI 10.1177/1054773814531600
   Kanaya AM, 2013, CLIN CARDIOL, V36, P713, DOI 10.1002/clc.22219
   Kanaya AM., 2014, J CLIN EXPT RES CARD, V1, P1, DOI [DOI 10.15744/2394-6504.1.102, https://doi.org/10.15744/2394-6504.1.102]
   Kandula NR, 2018, BMC PUBLIC HEALTH, V18, DOI 10.1186/s12889-018-5128-z
   Kent BV, 2021, J SCI STUD RELIG, V60, P198, DOI 10.1111/jssr.12695
   Kent BV, 2020, QUAL LIFE RES, V29, P495, DOI 10.1007/s11136-019-02321-7
   Kristiansen M, 2014, ETHNIC HEALTH, V19, P1, DOI 10.1080/13557858.2013.858108
   Kuo BCH, 2014, HEALTH PSYCHOL BEHAV, V2, P16, DOI 10.1080/21642850.2013.843459
   LAFROMBOISE T, 1993, PSYCHOL BULL, V114, P395, DOI 10.1037/0033-2909.114.3.395
   Lagisetty PA, 2016, J IMMIGR MINOR HEALT, V18, P1309, DOI 10.1007/s10903-015-0308-8
   Lancki Nicola, 2018, Obes Med, V11, P25, DOI 10.1016/j.obmed.2018.06.001
   Lechuga J, 2011, INT J INTERCULT REL, V35, P196, DOI 10.1016/j.ijintrel.2010.11.012
   Lee DL, 2012, COUNS PSYCHOL, V40, P28, DOI 10.1177/0011000011403326
   Liu JJ, 2016, HEALTH PROMOT INT, V31, P325, DOI 10.1093/heapro/dau105
   Lopez Gustavos., 2017, Pew Research Center
   Luu TD, 2009, SOC WORK MENT HEALTH, V7, P476, DOI 10.1080/15332980802467456
   Morales J, 2020, BMC ENDOCR DISORD, V20, DOI 10.1186/s12902-019-0483-z
   Nadimpalli SB, 2016, J IMMIGR MINOR HEALT, V18, P1284, DOI 10.1007/s10903-016-0413-3
   Nadimpalli SB, 2016, ASIAN AM J PSYCHOL, V7, P185, DOI 10.1037/aap0000037
   Needham BL, 2018, J IMMIGR MINOR HEALT, V20, P792, DOI 10.1007/s10903-017-0635-z
   Needham BL, 2017, J IMMIGR MINOR HEALT, V19, P373, DOI 10.1007/s10903-016-0372-8
   Ntuk UE, 2017, DIABETIC MED, V34, P1120, DOI 10.1111/dme.13323
   Ntuk UE, 2014, DIABETES CARE, V37, P2500, DOI 10.2337/dc13-2966
   Nylund KL, 2007, STRUCT EQU MODELING, V14, P535, DOI 10.1080/10705510701575396
   Pargament K, 2011, RELIGIONS, V2, P51, DOI 10.3390/rel2010051
   Philip S, 2019, J COLL COUNS, V22, P27, DOI 10.1002/jocc.12112
   Rudmin F, 2009, INT J INTERCULT REL, V33, P106, DOI 10.1016/j.ijintrel.2008.12.001
   Singer M, 2017, LANCET, V389, P941, DOI 10.1016/S0140-6736(17)30003-X
   Spence ND, 2020, AM J EPIDEMIOL, V189, P193, DOI 10.1093/aje/kwz222
   Spielberger C.D., 1994, The use of psychological testing for treatment planning and outcome assessment, P292, DOI [10.1002/9780470479216.corpsy0943, DOI 10.1002/9780470479216.CORPSY0943]
   Spielberger C.D., 1988, INDIVIDUAL DIFFERENC, P89, DOI [10.1007/978-1-4612-3824-95, DOI 10.1007/978-1-4612-3824-95, DOI 10.1007/978-1-4612-3824-9_5]
   Steffen P, 2011, MENT HEALTH RELIG CU, V14, P561, DOI 10.1080/13674676.2010.495747
   Steffen PR, 2006, PSYCHOSOM MED, V68, P386, DOI 10.1097/01.psy.0000221255.48190.32
   Stroope S, 2022, ETHNIC HEALTH, V27, P388, DOI 10.1080/13557858.2019.1661358
   Thanawala MS, 2020, J PHYS ACT HEALTH, V17, P149, DOI 10.1123/jpah.2019-0099
   Tirodkar MA, 2011, PATIENT EDUC COUNS, V85, P230, DOI 10.1016/j.pec.2010.10.002
   Tobin ET, 2016, HEALTH PSYCHOL, V35, P1356, DOI 10.1037/hea0000372
   Umana-Taylor Adriana J, 2007, Cultur Divers Ethnic Minor Psychol, V13, P178, DOI 10.1037/1099-9809.13.2.178
   Volgman AS, 2018, CIRCULATION, V138, pE1, DOI 10.1161/CIR.0000000000000580
   WHO, 2004, LANCET, V363, P902, DOI 10.1016/S0140-6736(03)15268-3
   Williams D R, 1997, J Health Psychol, V2, P335, DOI 10.1177/135910539700200305
   Zhou B, 2021, LANCET, V398, P957, DOI 10.1016/S0140-6736(21)01330-1
NR 69
TC 0
Z9 0
U1 1
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD OCT 8
PY 2024
VL 12
AR 1384607
DI 10.3389/fpubh.2024.1384607
PG 16
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA J5X3N
UT WOS:001337788600001
PM 39440183
OA gold
DA 2025-06-11
ER

PT J
AU Babic, R
   Maslov, B
   Babic, D
   Vasilj, I
AF Babic, Romana
   Maslov, Boris
   Babic, Dragan
   Vasilj, Ivan
TI THE PREVALENCE OF METABOLIC SYNDROME IN PATIENT WITH POSTTRAUMATIC
   STRESS DISORDER
SO PSYCHIATRIA DANUBINA
LA English
DT Article
DE metabolic syndrome; components; war; post-traumatic stress disorder;
   prevalence
ID DEPRESSION
AB Background: Although the connection between body and soul is written in the Bible, research papers haven't given much attention to it until the past few decades. Recently, both here and abroad, there have been more studies that investigate the prevalence of various somatic disorders in psychiatric patients, including metabolic syndrome.
   Objective: The objective of this study was to establish the prevalence of metabolic syndrome and it's components in patients with posttraumatic stress disorder (PTSD).
   Subjects and methods: Metabolic syndrome and its components were investigated in 60 patients with chronic PTSD conditioned by the war and in 60 patients treated for somatic problems by their family physician in Mostar.
   Results: The prevalence of metabolic syndrome was statistically significantly higher in patients with PTSD (48.3%) than in the control group (25%) (P=0.008) and the number of its individual components (test group 2.38 +/- 1.30 compared to control group 1.72 +/- 1.24) (P=0.005). PTSD patients diagnosed with metabolic syndrome had significantly more frequent hyperglycemia (P=0.010) and abdominal obesity (P=0.044) compared to the control group.
   Conclusion: The prevalence of metabolic syndrome increased in patients with PTSD compared to the control group.
C1 [Babic, Romana; Maslov, Boris; Babic, Dragan; Vasilj, Ivan] Univ Mostar, Sch Med, Dept Psychiat, Mostar 88000, Bosnia & Herceg.
   [Maslov, Boris; Babic, Dragan] Univ Clin Hosp Mostar, Dept Psychiat, Mostar, Bosnia & Herceg.
C3 University of Mostar; University of Mostar
RP Babic, R (corresponding author), Univ Mostar, Sch Med, Dept Psychiat, Mostar 88000, Bosnia & Herceg.
EM dragan.babic@tel.net.ba
RI Vasilj, Ivan/LKK-2729-2024
CR Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   Babic D, 2007, PSYCHIAT DANUB, V19, P68
   Babic D, 2010, PSYCHIAT DANUB, V22, P75
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Degmencic D, 2010, MEDIX, V89, P174
   Deykin EY, 2001, PSYCHOSOM MED, V63, P835, DOI 10.1097/00006842-200109000-00018
   Folnegovic-SMAlC Vera, 2010, Medix, V89-90, P134
   Goodwin RD, 2005, PREV MED, V40, P570, DOI 10.1016/j.ypmed.2004.07.013
   Jakovljevic M, 2010, PSYCHIAT DANUB, V20, P406
   Jakovljevic Miro, 2006, Psychiatr Danub, V18, P169
   Jakulica Marasovic, 2010, 5 HRVATSK PSIH K, P33
   Maia DB, 2008, J AFFECT DISORDERS, V107, P259, DOI 10.1016/j.jad.2007.08.013
   Maslov B, 2011, 3 HRVATSK K NUSP PSI, P93
   Maslov B, 2009, COLLEGIUM ANTROPOL, V33, P7
   MOLICA RF, 1992, HARVARD TRAUMA MANUA
   Perlmutter J B, 2000, Heart Dis, V2, P75
   Schweiger U, 2000, AM J PSYCHIAT, V157, P118, DOI 10.1176/ajp.157.1.118
   Takeshita J, 2002, AM J PSYCHIAT, V159, P1127, DOI 10.1176/appi.ajp.159.7.1127
   Weber-Hamann B, 2002, PSYCHOSOM MED, V64, P274, DOI 10.1097/00006842-200203000-00010
   Weisberg RB, 2002, PSYCHIATR SERV, V53, P848, DOI 10.1176/appi.ps.53.7.848
NR 20
TC 17
Z9 18
U1 0
U2 17
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PY 2013
VL 25
SU 1
BP 45
EP 50
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AK7TZ
UT WOS:000338631900008
PM 23806967
DA 2025-06-11
ER

PT J
AU Zimmet, P
   Alberti, KGMM
   Stern, N
   Bilu, C
   El-Osta, A
   Einat, H
   Kronfeld-Schor, N
AF Zimmet, P.
   Alberti, K. G. M. M.
   Stern, N.
   Bilu, C.
   El-Osta, A.
   Einat, H.
   Kronfeld-Schor, N.
TI The Circadian Syndrome: is the Metabolic Syndrome and much more!
SO JOURNAL OF INTERNAL MEDICINE
LA English
DT Review
DE circadian clock; diabetes; metabolic syndrome
ID ANXIETY-LIKE BEHAVIORS; BLOOD-PRESSURE; LIGHT THERAPY; NONSEASONAL
   DEPRESSION; SAND RAT; COMORBID DEPRESSION; INSULIN-RESISTANCE;
   EPIGENETIC CHANGES; GENE-EXPRESSION; DIURNAL RODENTS
AB The Metabolic Syndrome is a cluster of cardio-metabolic risk factors and comorbidities conveying high risk of both cardiovascular disease and type 2 diabetes. It is responsible for huge socio-economic costs with its resulting morbidity and mortality in most countries. The underlying aetiology of this clustering has been the subject of much debate. More recently, significant interest has focussed on the involvement of the circadian system, a major regulator of almost every aspect of human health and metabolism. The Circadian Syndrome has now been implicated in several chronic diseases including type 2 diabetes and cardiovascular disease. There is now increasing evidence connecting disturbances in circadian rhythm with not only the key components of the Metabolic Syndrome but also its main comorbidities including sleep disturbances, depression, steatohepatitis and cognitive dysfunction. Based on this, we now propose that circadian disruption may be an important underlying aetiological factor for the Metabolic Syndrome and we suggest that it be renamed the 'Circadian Syndrome'. With the increased recognition of the 'Circadian Syndrome', circadian medicine, through the timing of exercise, light exposure, food consumption, dispensing of medications and sleep, is likely to play a much greater role in the maintenance of both individual and population health in the future.
C1 [Zimmet, P.; El-Osta, A.] Monash Univ, Cent Clin Sch, Dept Diabet, Melbourne, Vic, Australia.
   [Zimmet, P.; Stern, N.] Tel Aviv Med Ctr & Sch Med, Sagol Ctr Epigenet & Metab, Tel Aviv, Israel.
   [Alberti, K. G. M. M.] Imperial Coll, London, England.
   [Bilu, C.; Kronfeld-Schor, N.] Tel Aviv Univ, Sch Zool, Tel Aviv, Israel.
   [El-Osta, A.] Univ Melbourne, Dept Pathol, Parkville, Vic, Australia.
   [El-Osta, A.] Chinese Univ Hong Kong, Prince Wales Hosp, Hong Kong Inst Diabet & Obes, Hong Kong, Peoples R China.
   [Einat, H.] Tel Aviv Yaffo Acad Coll, Sch Behav Sci, Tel Aviv, Israel.
C3 Monash University; Tel Aviv University; Sackler Faculty of Medicine;
   Imperial College London; Tel Aviv University; University of Melbourne;
   Chinese University of Hong Kong; Prince of Wales Hospital
RP Zimmet, P (corresponding author), Monash Diabet, Alfred Ctr, Level 5,99 Commercial Rd, Melbourne, Vic 3004, Australia.
EM paul.zimmet@monash.edu
RI Kronfeld-Schor, Noga/AAU-3792-2020; Zimmet, Paul/H-7635-2013; Einat,
   Haim/AAZ-9746-2020
OI El-Osta, Assam/0000-0003-2969-9137; Kronfeld-Schor,
   Noga/0000-0002-5224-3341
FU Israel Science Foundation [866/17]
FX This research was supported by the Israel Science Foundation grant (No.
   866/17) to NKS.
CR Adamovich Y, 2014, CELL METAB, V19, P319, DOI 10.1016/j.cmet.2013.12.016
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Almoosawi S, 2019, ADV NUTR, V10, P30, DOI 10.1093/advances/nmy070
   Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   Ashkenazy T, 2009, BEHAV BRAIN RES, V201, P343, DOI 10.1016/j.bbr.2009.03.005
   Ashkenazy T, 2009, INT J NEUROPSYCHOPH, V12, P83, DOI 10.1017/S1461145708009115
   Ashkenazy-Frolinger T, 2013, J NEURAL TRANSM, P35
   Banegas JR, 2018, NEW ENGL J MED, V378, P1509, DOI 10.1056/NEJMoa1712231
   BARNETT M, 1994, INT J OBESITY, V18, P789
   Barres R, 2011, AM J CLIN NUTR, V93, p897S, DOI 10.3945/ajcn.110.001933
   Bilu C, 2019, J BIOL RHYTHM, V34, P69, DOI 10.1177/0748730418819373
   Bilu C, 2016, DRUG DEVELOP RES, V77, P336, DOI 10.1002/ddr.21346
   Black N, 2019, HEART RHYTHM, V16, P298, DOI 10.1016/j.hrthm.2018.08.026
   Block T, 2017, ATHEROSCLEROSIS, V266, P31, DOI 10.1016/j.atherosclerosis.2017.09.003
   Bray MS, 2007, OBES REV, V8, P169, DOI 10.1111/j.1467-789X.2006.00277.x
   Brouwer A, 2015, BMC PSYCHIATRY, V15, DOI 10.1186/s12888-015-0543-5
   Campayo A, 2011, CURR PSYCHIAT REP, V13, P26, DOI 10.1007/s11920-010-0165-z
   Casitas R, 2017, EUR RESPIR J, V50, DOI 10.1183/13993003.01261-2017
   Cedernaes J, 2018, SCI ADV, V4, DOI 10.1126/sciadv.aar8590
   Cleary C, 2008, BRAIN RES BULL, V76, P469, DOI 10.1016/j.brainresbull.2008.03.005
   Coomans CP, 2013, DIABETES, V62, P1102, DOI 10.2337/db12-0507
   Crnko S, 2019, NAT REV CARDIOL, V16, P437, DOI 10.1038/s41569-019-0167-4
   de la Sierra A, 2009, HYPERTENSION, V53, P466, DOI 10.1161/HYPERTENSIONAHA.108.124008
   Diamond J, 2003, NATURE, V423, P599, DOI 10.1038/423599a
   Dibner C, 2015, J INTERN MED, V277, P513, DOI 10.1111/joim.12347
   DIETZEL M, 1986, EUR NEUROL, V25, P93, DOI 10.1159/000116089
   Dominoni DM, 2016, BIOL LETTERS, V12, DOI 10.1098/rsbl.2016.0015
   Durgan DJ, 2010, CIRC RES, V106, P647, DOI 10.1161/CIRCRESAHA.109.209957
   Egede LE, 2002, DIABETES CARE, V25, P464, DOI 10.2337/diacare.25.3.464
   Einat H, 2006, BEHAV BRAIN RES, V173, P153, DOI 10.1016/j.bbr.2006.06.006
   El-Osta A, 2008, J EXP MED, V205, P2409, DOI 10.1084/jem.20081188
   Even C, 2008, J AFFECT DISORDERS, V108, P11, DOI 10.1016/j.jad.2007.09.008
   Fabbian F, 2013, CHRONOBIOL INT, V30, P17, DOI 10.3109/07420528.2012.715872
   Froy O, 2010, ENDOCR REV, V31, P1, DOI 10.1210/er.2009-0014
   Gale JE, 2011, J BIOL RHYTHM, V26, P423, DOI 10.1177/0748730411416341
   Gluckman PD, 2009, NAT REV ENDOCRINOL, V5, P401, DOI 10.1038/nrendo.2009.102
   Gnocchi Davide, 2015, Biology-Basel, V4, P104, DOI 10.3390/biology4010104
   Golden RN, 2005, AM J PSYCHIAT, V162, P656, DOI 10.1176/appi.ajp.162.4.656
   Golden SH, 2008, JAMA-J AM MED ASSOC, V299, P2751, DOI 10.1001/jama.299.23.2751
   Gramaglia C, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00621
   Grant PJ, 2008, DIABETES VASC DIS RE, V5, P75, DOI 10.3132/dvdr.2008.0012
   Grundy SM, 2006, DIABETES CARE, V29, P1689, DOI 10.2337/dc05-2307
   Hassan MO, 2007, OBESITY, V15, P2445, DOI 10.1038/oby.2007.290
   Hermida RC, 2011, AM J HYPERTENS, V24, P383, DOI 10.1038/ajh.2010.217
   Javeed N, 2018, PHYSIOLOGY, V33, P138, DOI 10.1152/physiol.00003.2018
   Jha PK, 2015, MOL CELL ENDOCRINOL, V418, P74, DOI 10.1016/j.mce.2015.01.024
   Kadono M, 2016, J SLEEP RES, V25, P426, DOI 10.1111/jsr.12385
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   Kahn R, 2006, DIABETES CARE, V29, P1693, DOI 10.2337/dc06-0671
   Kaiser Nurit, 2012, Methods Mol Biol, V933, P89, DOI 10.1007/978-1-62703-068-7_7
   Kalman R, 2012, AM COLL LAB, P1171, DOI 10.1016/B978-0-12-380920-9.00054-7
   Kalsbeek A, 2014, MOL METAB, V3, P372, DOI 10.1016/j.molmet.2014.03.002
   Kalsbeek A, 2011, FEBS LETT, V585, P1412, DOI 10.1016/j.febslet.2011.03.021
   Kaspi A, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201800134
   Keating ST, 2018, DIABETOLOGIA, V61, P6, DOI 10.1007/s00125-017-4490-1
   Keating ST, 2016, CIRC RES, V118, P1706, DOI 10.1161/CIRCRESAHA.116.306819
   Khurana I, 2016, INT J OBESITY, V40, P1079, DOI 10.1038/ijo.2016.64
   Kripke DF, 1998, J AFFECT DISORDERS, V49, P109, DOI 10.1016/S0165-0327(98)00005-6
   Krivisky K, 2012, J NEURAL TRANSM, V119, P1241, DOI 10.1007/s00702-012-0783-1
   Kronfeld-Schor N, 2017, PHILOS T R SOC B, V372, DOI 10.1098/rstb.2016.0248
   Kronfeld-Schor N, 2012, NEUROPHARMACOLOGY, V62, P101, DOI 10.1016/j.neuropharm.2011.08.020
   Kuhlman SJ, 2018, CSH PERSPECT BIOL, V10, DOI 10.1101/cshperspect.a033613
   Li Min-Dian, 2012, Yale Journal of Biology and Medicine, V85, P387
   Logan RW, 2019, NAT REV NEUROSCI, V20, P49, DOI 10.1038/s41583-018-0088-y
   McClung CA, 2007, PHARMACOL THERAPEUT, V114, P222, DOI 10.1016/j.pharmthera.2007.02.003
   McClung CA, 2013, BIOL PSYCHIAT, V74, P242, DOI 10.1016/j.biopsych.2013.02.019
   McIntyre Roger S, 2007, Ann Clin Psychiatry, V19, P257, DOI 10.1080/10401230701653377
   Noordam R, 2019, J CLIN ENDOCR METAB, V104, P2903, DOI 10.1210/jc.2018-02532
   Okabe J, 2012, CIRC RES, V110, P1067, DOI 10.1161/CIRCRESAHA.112.266171
   Oldham MA, 2014, CHRONOBIOL INT, V31, P305, DOI 10.3109/07420528.2013.833935
   Orozco-Solis R, 2014, NEUROSCIENCE, V264, P76, DOI 10.1016/j.neuroscience.2014.01.043
   Ouyang JQ, 2018, J EXP BIOL, V221, DOI 10.1242/jeb.156893
   Panda M, 2019, SN APPL SCI, V1, DOI 10.1007/s42452-019-0234-9
   Panda S, 2016, SCIENCE, V354, P1008, DOI 10.1126/science.aah4967
   Prasai MJ, 2008, DIABETES VASC DIS RE, V5, P89, DOI 10.3132/dvdr.2008.015
   Qian J, 2018, SLEEP, V41, pA17, DOI 10.1093/sleep/zsy061.040
   Qian JY, 2016, TRENDS ENDOCRIN MET, V27, P282, DOI 10.1016/j.tem.2016.03.005
   Rakshit K, 2014, CURR DIABETES REP, V14, DOI 10.1007/s11892-014-0474-4
   Reaven GM, 2011, J INTERN MED, V269, P127, DOI 10.1111/j.1365-2796.2010.02325.x
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Reinke H, 2016, GASTROENTEROLOGY, V150, P574, DOI 10.1053/j.gastro.2015.11.043
   Rüger M, 2009, REV ENDOCR METAB DIS, V10, P245, DOI 10.1007/s11154-009-9122-8
   Sato S, 2019, CURR OPIN BEHAV SCI, V25, P15, DOI 10.1016/j.cobeha.2018.05.010
   Schein ASO, 2014, J HYPERTENS, V32, P1762, DOI 10.1097/HJH.0000000000000250
   SCHMIDTNIELSEN K, 1964, SCIENCE, V143, P689, DOI 10.1126/science.143.3607.689
   Shaw E, 2009, CURR ATHEROSCLER REP, V11, P289, DOI 10.1007/s11883-009-0044-4
   Skene DJ, 2018, P NATL ACAD SCI USA, V115, P7825, DOI 10.1073/pnas.1801183115
   Smolensky MH, 2007, SLEEP MED, V8, P668, DOI 10.1016/j.sleep.2006.11.011
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Spiegel K, 2005, J APPL PHYSIOL, V99, P2008, DOI 10.1152/japplphysiol.00660.2005
   Staels B, 2006, NAT MED, V12, P54, DOI 10.1038/nm0106-54
   Stenvers DJ, 2019, DIABETOLOGIA, V62, P704, DOI 10.1007/s00125-019-4813-5
   Stenvers DJ, 2019, NAT REV ENDOCRINOL, V15, P75, DOI 10.1038/s41574-018-0122-1
   Stevenson TJ, 2015, P ROY SOC B-BIOL SCI, V282, DOI 10.1098/rspb.2015.1453
   Tal-Krivisky K, 2015, PHYSIOL BEHAV, V151, P441, DOI 10.1016/j.physbeh.2015.08.002
   Terman M, 2005, CNS SPECTRUMS, V10, P647, DOI 10.1017/S1092852900019611
   Thosar SS, 2018, J CLIN INVEST, V128, P2157, DOI 10.1172/JCI80590
   Top D, 2018, CSH PERSPECT BIOL, V10, DOI 10.1101/cshperspect.a033589
   Van Laake LW, 2018, EUR HEART J, V39, P2326, DOI 10.1093/eurheartj/ehx775
   Versteeg RI, 2016, P NUTR SOC, V75, P451, DOI 10.1017/S0029665116000707
   Vgontzas AN, 2005, SLEEP MED REV, V9, P211, DOI 10.1016/j.smrv.2005.01.006
   Wirz-Justice A, 1998, ARCH GEN PSYCHIAT, V55, P861, DOI 10.1001/archpsyc.55.10.861
   Wyse CA, 2017, ANN MED, V49, P411, DOI 10.1080/07853890.2017.1292045
   Yaffe K, 2007, ALZ DIS ASSOC DIS, V21, P167, DOI 10.1097/WAD.0b013e318065bfd6
   YAMADA N, 1995, BIOL PSYCHIAT, V37, P866, DOI 10.1016/0006-3223(94)00221-N
   Yu JS, 2016, GASTROENT RES PRACT, V2016, DOI 10.1155/2016/2862173
   Zimmet PZ, 2016, DIABETES CARE, V39, P878, DOI 10.2337/dc16-0273
   Zimmet PZ, 2014, LANCET DIABETES ENDO, V2, P56, DOI 10.1016/S2213-8587(13)70112-8
   ZIMMET PZ, 1974, BMJ-BRIT MED J, V1, P485, DOI 10.1136/bmj.1.5906.485
NR 110
TC 206
Z9 221
U1 10
U2 63
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0954-6820
EI 1365-2796
J9 J INTERN MED
JI J. Intern. Med.
PD AUG
PY 2019
VL 286
IS 2
BP 181
EP 191
DI 10.1111/joim.12924
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IJ0YB
UT WOS:000475624800004
PM 31081577
OA Green Published, hybrid
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Zimmermann, MB
   Aeberli, I
AF Zimmermann, M. B.
   Aeberli, I.
TI Dietary determinants of subclinical inflammation, dyslipidemia and
   components of the metabolic syndrome in overweight children: a review
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article; Proceedings Paper
CT 4th Fribourg Obesity Research Conference
CY SEP 14, 2007
CL Fribourg, SWITZERLAND
DE child; metabolic syndrome; diet; inflammation; adipokine
ID C-REACTIVE PROTEIN; TUMOR-NECROSIS-FACTOR; RETINOL-BINDING-PROTEIN;
   LOW-DENSITY-LIPOPROTEIN; POLYUNSATURATED FATTY-ACIDS; GRADE SYSTEMIC
   INFLAMMATION; CARDIOVASCULAR RISK-FACTORS; INSULIN-RESISTANCE SYNDROME;
   INCREASED OXIDATIVE STRESS; VITAMIN-A-DEFICIENCY
AB Objective: To review and summarize the dietary determinants of the metabolic syndrome, subclinical inflammation and dyslipidemia in overweight children.
   Design: Review of the current literature, focusing on pediatric studies.
   Participants: Normal weight, overweight, or obese children and adolescents.
   Results: There is a growing literature on the metabolic effects of excess body fat during childhood. However, few pediatric studies have examined the dietary determinants of obesity-related metabolic disturbances. From the available data, it appears that dietary factors are not only important environmental determinants of adiposity, but also may affect components of the metabolic syndrome and modulate the actions of adipokines. Dietary total fat and saturated fat are associated with insulin resistance and high blood pressure, as well as obesity-related inflammation. In contrast to studies in adults, resistin and adiponectin do not appear to be closely linked to insulin resistance or dyslipidemia in childhood. However, circulating leptin and retinol-binding protein (RBP) 4 correlate well with obesity, central obesity and the metabolic syndrome in children. Intakes of antioxidant vitamins tend to be low in obese children and may be predictors of subclinical inflammation. Higher fructose intake from sweets and sweetened drinks in overweight children has been linked to decreased low-density lipoprotein (LDL) particle size.
   Conclusions: Dietary interventions aimed at reducing intakes of total fat, saturated fat and free fructose, whereas increasing antioxidant vitamin intake may be beneficial in overweight children. More research on the relationships between dietary factors and the metabolic changes of pediatric obesity may help to identify the dietary changes to reduce health risks.
C1 [Zimmermann, M. B.; Aeberli, I.] ETH, Human Nutr Lab, Inst Food Sci & Nutr, CH-8092 Zurich, Switzerland.
   [Zimmermann, M. B.] Wageningen Univ, Div Human Nutr, Wageningen, Netherlands.
C3 Swiss Federal Institutes of Technology Domain; ETH Zurich; Wageningen
   University & Research
RP Zimmermann, MB (corresponding author), ETH, Human Nutr Lab, Inst Food Sci & Nutr, LFV E19,Schmelzbergstr 7, CH-8092 Zurich, Switzerland.
EM michael.zimmermann@ilw.agrl.ethz.ch
RI Zimmermann, Michael/C-3062-2016; Herter-Aeberli, Isabelle/C-8580-2013
OI Herter-Aeberli, Isabelle/0000-0003-0134-6217
CR Abahusain MA, 1999, EUR J CLIN NUTR, V53, P630, DOI 10.1038/sj.ejcn.1600825
   AEBERLI I, 2008, INT J VIT N IN PRESS
   Aeberli I, 2007, J CLIN ENDOCR METAB, V92, P4359, DOI 10.1210/jc.2007-0468
   Aeberli I, 2007, AM J CLIN NUTR, V86, P1174, DOI 10.1093/ajcn/86.4.1174
   Aeberli I, 2006, AM J CLIN NUTR, V84, P748, DOI 10.1093/ajcn/84.4.748
   Ajuwon KM, 2005, J NUTR, V135, P1841, DOI 10.1093/jn/135.8.1841
   Appel LJ, 2006, HYPERTENSION, V47, P296, DOI 10.1161/01.HYP.0000202568.01167.B6
   Balagopal P, 2007, J CLIN ENDOCR METAB, V92, P1971, DOI 10.1210/jc.2006-2712
   Bantle JP, 2000, AM J CLIN NUTR, V72, P1128
   BAO WH, 1995, AM J HYPERTENS, V8, P657, DOI 10.1016/0895-7061(95)00116-7
   Barbagallo CM, 2002, AM J CARDIOL, V89, P460, DOI 10.1016/S0002-9149(01)02270-6
   Basu TK, 1997, NUTRITION, V13, P804, DOI 10.1016/S0899-9007(97)00192-5
   Bemelmans WJE, 2004, EUR J CLIN NUTR, V58, P1083, DOI 10.1038/sj.ejcn.1601938
   Berneis KK, 2002, J LIPID RES, V43, P1363, DOI 10.1194/jlr.R200004-JLR200
   BLANER WS, 1989, ENDOCR REV, V10, P308, DOI 10.1210/edrv-10-3-308
   Bray GA, 2002, J NUTR, V132, P2488, DOI 10.1093/jn/132.9.2488
   Bray GA, 2004, AM J CLIN NUTR, V79, P537
   BROWNELL KD, 1983, PEDIATRICS, V71, P515
   Browning LM, 2006, DIABETES TECHNOL THE, V8, P45, DOI 10.1089/dia.2006.8.45
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Chambon P, 1996, FASEB J, V10, P940, DOI 10.1096/fasebj.10.9.8801176
   Cho YM, 2006, DIABETES CARE, V29, P2457, DOI 10.2337/dc06-0360
   Chu NF, 2001, AM J HYPERTENS, V14, P135, DOI 10.1016/S0895-7061(00)01243-7
   Chung SK, 2005, J BIOL CHEM, V280, P38445, DOI 10.1074/jbc.M508159200
   Cook DG, 2000, ATHEROSCLEROSIS, V149, P139, DOI 10.1016/S0021-9150(99)00312-3
   Couch SC, 2005, CURR OPIN PEDIATR, V17, P642, DOI 10.1097/01.mop.0000172817.87261.4f
   CRAPO PA, 1984, AM J CLIN NUTR, V39, P525, DOI 10.1093/ajcn/39.4.525
   Cruz ML, 2005, ANNU REV NUTR, V25, P435, DOI 10.1146/annurev.nutr.25.050304.092625
   Cunningham-Rundles S, 2005, J ALLERGY CLIN IMMUN, V115, P1119, DOI 10.1016/j.jaci.2005.04.036
   Davì G, 2002, JAMA-J AM MED ASSOC, V288, P2008, DOI 10.1001/jama.288.16.2008
   de Pee S, 2002, J NUTR, V132, p2895S, DOI 10.1093/jn/132.9.2895S
   Decsi T, 1996, INT J OBESITY, V20, P970
   DREON DM, 1994, FASEB J, V8, P121, DOI 10.1096/fasebj.8.1.8299884
   Dreon DM, 1999, AM J CLIN NUTR, V69, P411
   Dubuc GR, 1998, METABOLISM, V47, P429, DOI 10.1016/S0026-0495(98)90055-5
   Elliott SS, 2002, AM J CLIN NUTR, V76, P911, DOI 10.1093/ajcn/76.5.911
   ENDRES S, 1989, NEW ENGL J MED, V320, P265, DOI 10.1056/NEJM198902023200501
   Erikstrup C, 2006, NEW ENGL J MED, V355, P1393
   Faeh D, 2005, DIABETES, V54, P1907, DOI 10.2337/diabetes.54.7.1907
   Ferré P, 2004, DIABETES, V53, pS43, DOI 10.2337/diabetes.53.2007.S43
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Festa A, 2001, INT J OBESITY, V25, P1407, DOI 10.1038/sj.ijo.0801792
   Ford ES, 2003, CIRCULATION, V108, P1053, DOI 10.1161/01.CIR.0000080913.81393.B8
   Fung TT, 2001, AM J CLIN NUTR, V73, P61
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gerber M, 2005, J CLIN ENDOCR METAB, V90, P4503, DOI 10.1210/jc.2005-0437
   Gidding Samuel S, 2005, Circulation, V112, P2061, DOI 10.1161/CIRCULATIONAHA.105.169251
   GOLDBERG RJ, 1992, AM J CLIN NUTR, V56, P71, DOI 10.1093/ajcn/56.1.71
   Gouni-Berthold I, 2005, J INTERN MED, V258, P518, DOI 10.1111/j.1365-2796.2005.01566.x
   Graham TE, 2006, NEW ENGL J MED, V355, P1394
   Graham TE, 2006, NEW ENGL J MED, V354, P2552, DOI 10.1056/NEJMoa054862
   Gupta A, 2005, J PEDIATR ENDOCR MET, V18, P75
   GUPTA AK, 1992, HYPERTENSION      S1, V19, P78
   Gutin B, 1999, AM J CLIN NUTR, V69, P388
   HAIDER GD, 2002, J CLIN ENDOCR METAB, V92, P1168
   Hakanen M, 2004, PEDIATRICS, V113, P1273, DOI 10.1542/peds.113.5.1273
   Halle M, 2004, EXERC IMMUNOL REV, V10, P66
   Härtel C, 2004, CYTOKINE, V27, P101, DOI 10.1016/j.cyto.2004.02.004
   Havel PJ, 1999, DIABETES, V48, P334, DOI 10.2337/diabetes.48.2.334
   Haynes WG, 1997, J CLIN INVEST, V100, P270, DOI 10.1172/JCI119532
   Helmersson J, 2004, CIRCULATION, V109, P1729, DOI 10.1161/01.CIR.0000124718.99562.91
   Hirose H, 1998, J HYPERTENS, V16, P2007, DOI 10.1097/00004872-199816121-00023
   Janke J, 2006, DIABETES, V55, P2805, DOI 10.2337/db06-0616
   JIANG XZ, 1993, ARCH INTERN MED, V153, P323, DOI 10.1001/archinte.153.3.323
   Jové M, 2005, ENDOCRINOLOGY, V146, P3087, DOI 10.1210/en.2004-1560
   Jürgens H, 2005, OBES RES, V13, P1146, DOI 10.1038/oby.2005.136
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Kelley DS, 2001, NUTRITION, V17, P669, DOI 10.1016/S0899-9007(01)00576-7
   Kern PA, 2001, AM J PHYSIOL-ENDOC M, V280, pE745
   Klein-Platat C, 2005, AM J CLIN NUTR, V82, P1178, DOI 10.1093/ajcn/82.6.1178
   Kliewer SA, 2001, RECENT PROG HORM RES, V56, P239, DOI 10.1210/rp.56.1.239
   Koistinen HA, 2001, DIABETES-METAB RES, V17, P391, DOI 10.1002/dmrr.222
   Kokot F, 1999, KIDNEY BLOOD PRESS R, V22, P154, DOI 10.1159/000025922
   Kolaczynski JW, 1996, J CLIN ENDOCR METAB, V81, P4162, DOI 10.1210/jc.81.11.4162
   KREMER JM, 1990, ARTHRITIS RHEUM-US, V33, P810, DOI 10.1002/art.1780330607
   Kuno T, 1998, FREE RADICAL RES, V28, P81, DOI 10.3109/10715769809097878
   Lambert M, 2004, CLIN CHEM, V50, P1762, DOI 10.1373/clinchem.2004.036418
   LANDSBERG L, 1992, HYPERTENSION, V19, pI61, DOI 10.1161/01.HYP.19.1_Suppl.I61
   Lee DC, 2007, METABOLISM, V56, P327, DOI 10.1016/j.metabol.2006.10.011
   Lee JH, 2003, J CLIN ENDOCR METAB, V88, P4848, DOI 10.1210/jc.2003-030519
   Lembo G, 2000, DIABETES, V49, P293, DOI 10.2337/diabetes.49.2.293
   Lemieux I, 2001, ARTERIOSCL THROM VAS, V21, P961, DOI 10.1161/01.ATV.21.6.961
   Lespine A, 1996, J LIPID RES, V37, P2492
   Lofgren IE, 2005, J NUTR BIOCHEM, V16, P245, DOI 10.1016/j.jnutbio.2004.12.008
   Mantzioris E, 2000, AM J CLIN NUTR, V72, P42
   Marill J, 2003, CURR DRUG METAB, V4, P1, DOI 10.2174/1389200033336900
   Marshall JA, 1997, DIABETOLOGIA, V40, P430, DOI 10.1007/s001250050697
   McGarry JD, 2002, DIABETES, V51, P7, DOI 10.2337/diabetes.51.1.7
   McTernan CL, 2002, LANCET, V359, P46, DOI 10.1016/S0140-6736(02)07281-1
   Meigs JB, 1997, DIABETES, V46, P1594, DOI 10.2337/diabetes.46.10.1594
   MILLAND J, 1990, AM J PHYSIOL, V259, pG340, DOI 10.1152/ajpgi.1990.259.3.G340
   Mohamed-Ali V, 1997, J CLIN ENDOCR METAB, V82, P4196, DOI 10.1210/jc.82.12.4196
   Mohn A, 2005, J CLIN ENDOCR METAB, V90, P2653, DOI 10.1210/jc.2004-2178
   Molnár D, 2004, INT J OBESITY, V28, P1197, DOI 10.1038/sj.ijo.0802719
   Molnár D, 2000, EUR J PEDIATR, V159, pS45, DOI 10.1007/PL00014365
   MONACO HL, 1995, SCIENCE, V268, P1039, DOI 10.1126/science.7754382
   Mukherjee R, 2005, DRUG TODAY, V41, P687, DOI 10.1358/dot.2005.41.10.899612
   Natl High Blood Pressure Educ Prog, 2004, PEDIATRICS, V114, P555
   Olusi SO, 2002, INT J OBESITY, V26, P1159, DOI 10.1038/sj.ijo.0802066
   Ong KK, 2006, DIABETES, V55, P1337, DOI 10.2337/db05-1272
   Phinney SD, 2005, AM J CLIN NUTR, V82, P1151, DOI 10.1093/ajcn/82.6.1151
   Pradhan AD, 2003, ARTERIOSCL THROM VAS, V23, P650, DOI 10.1161/01.ATV.0000065636.15310.9C
   Punthakee Z, 2006, J CLIN ENDOCR METAB, V91, P2119, DOI 10.1210/jc.2005-2346
   Rallidis LS, 2003, ATHEROSCLEROSIS, V167, P237, DOI 10.1016/S0021-9150(02)00427-6
   Reinehr T, 2005, METABOLISM, V54, P1155, DOI 10.1016/j.metabol.2005.03.022
   Reinehr T, 2004, ARCH DIS CHILD, V89, P419, DOI 10.1136/adc.2003.028803
   REISER S, 1989, AM J CLIN NUTR, V49, P832, DOI 10.1093/ajcn/49.5.832
   SASAKI H, 1995, AM J MED SCI, V310, P177, DOI 10.1097/00000441-199511000-00001
   SimonsMorton DG, 1997, PEDIATR NEPHROL, V11, P244, DOI 10.1007/s004670050271
   SimonsMorton DG, 1997, HYPERTENSION, V29, P930, DOI 10.1161/01.HYP.29.4.930
   Sinaiko AR, 2002, J HYPERTENS, V20, P509, DOI 10.1097/00004872-200203000-00027
   SIVITZ WI, 1989, NATURE, V340, P72, DOI 10.1038/340072a0
   SMITH FR, 1971, J CLIN INVEST, V50, P2426, DOI 10.1172/JCI106741
   Soprano Dianne Robert, 1994, P257
   Staiger H, 2004, DIABETES, V53, P3209, DOI 10.2337/diabetes.53.12.3209
   Steinbeck K, 2005, BEST PRACT RES CL EN, V19, P455, DOI 10.1016/j.beem.2005.04.010
   Steppan CM, 2001, NATURE, V409, P307, DOI 10.1038/35053000
   STERN B, 1980, NUTR METAB, V24, P137
   STOUT RW, 1975, CIRC RES, V36, P319, DOI 10.1161/01.RES.36.2.319
   Strauss RS, 1999, J PEDIATR-US, V134, P160, DOI 10.1016/S0022-3476(99)70409-9
   Takashima N, 2006, NEW ENGL J MED, V355, P1392
   Teng XW, 2003, CIRC RES, V92, P1065, DOI 10.1161/01.RES.0000073999.07698.33
   Thurnham DI, 2003, LANCET, V362, P2052, DOI 10.1016/S0140-6736(03)15099-4
   Trebble T, 2003, BRIT J NUTR, V90, P405, DOI 10.1079/BJN2003892
   Ukkola O, 2002, EUR J ENDOCRINOL, V147, P571, DOI 10.1530/eje.0.1470571
   Urakawa H, 2003, J CLIN ENDOCR METAB, V88, P4673, DOI 10.1210/jc.2003-030202
   Verma S, 2003, CIRCULATION, V108, P736, DOI 10.1161/01.CIR.0000084503.91330.49
   Vessby B, 2000, BRIT J NUTR, V83, pS91
   Visser M, 2001, PEDIATRICS, V107, DOI 10.1542/peds.107.1.e13
   Vogel S, 1997, AM J CLIN NUTR, V66, P950, DOI 10.1093/ajcn/66.4.950
   Wagnerberger S, 2006, ALCOHOL, V38, P37, DOI 10.1016/j.alcohol.2006.03.007
   Weiss R, 2005, BEST PRACT RES CL EN, V19, P405, DOI 10.1016/j.beem.2005.04.009
   Weiss R, 2004, NEW ENGL J MED, V350, P2362, DOI 10.1056/NEJMoa031049
   Wellen KE, 2003, J CLIN INVEST, V112, P1785, DOI 10.1172/JCI20514
   Wu DM, 2003, J CLIN EPIDEMIOL, V56, P94, DOI 10.1016/S0895-4356(02)00519-X
   Xu HY, 2002, DIABETES, V51, P1876, DOI 10.2337/diabetes.51.6.1876
   Yang Q, 2005, NATURE, V436, P356, DOI 10.1038/nature03711
   Yannakoulia M, 2003, J CLIN ENDOCR METAB, V88, P1730, DOI 10.1210/jc.2002-021604
   Yoshida A, 2006, J ATHEROSCLER THROMB, V13, P209, DOI 10.5551/jat.13.209
   Yudkin JS, 1999, ARTERIOSCL THROM VAS, V19, P972, DOI 10.1161/01.ATV.19.4.972
   Zhao GX, 2004, J NUTR, V134, P2991, DOI 10.1093/jn/134.11.2991
   Zhao GX, 2005, BIOCHEM BIOPH RES CO, V336, P909, DOI 10.1016/j.bbrc.2005.08.204
   Zimmermann MB, 2004, AM J CLIN NUTR, V79, P838
NR 143
TC 50
Z9 57
U1 0
U2 5
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD DEC
PY 2008
VL 32
SU 6
BP S11
EP S18
DI 10.1038/ijo.2008.202
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 384AY
UT WOS:000261717100003
PM 19079275
DA 2025-06-11
ER

PT J
AU Jacobsen, HB
   Reme, SE
   Sembajwe, G
   Hopcia, K
   Stiles, TC
   Sorensen, G
   Porter, JH
   Marino, M
   Buxton, OM
AF Jacobsen, Henrik B.
   Reme, Silje E.
   Sembajwe, Grace
   Hopcia, Karen
   Stiles, Tore C.
   Sorensen, Glorian
   Porter, James H.
   Marino, Miguel
   Buxton, Orfeu M.
TI Work Stress, Sleep Deficiency, and Predicted 10-Year Cardiometabolic
   Risk in a Female Patient Care Worker Population
SO AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
LA English
DT Article
DE cardiometabolic risk; nurses; sleep maintenance; physical activity;
   follow-up; work-family conflict
ID CORONARY-HEART-DISEASE; ALL-CAUSE MORTALITY; PHYSICAL-ACTIVITY; SHIFT
   WORK; CARDIOVASCULAR-DISEASE; DURATION; OBESITY; ASSOCIATION; ADULTS;
   HYPERTENSION
AB Objectives The aim of this study was to investigate the longitudinal effect of work-related stress, sleep deficiency, and physical activity on 10-year cardiometabolic risk among an all-female worker population.
   Methods Data on patient care workers (n = 99) was collected 2 years apart. Baseline measures included: job stress, physical activity, night work, and sleep deficiency. Biomarkers and objective measurements were used to estimate 10-year cardiometabolic risk at follow-up. Significant associations (P < 0.05) from baseline analyses were used to build a multivariable linear regression model.
   Results The participants were mostly white nurses with a mean age of 41 years. Adjusted linear regression showed that having sleep maintenance problems, a different occupation than nurse, and/or not exercising at recommended levels at baseline increased the 10-year cardiometabolic risk at follow-up.
   Conclusions In female workers prone to work-related stress and sleep deficiency, maintaining sleep and exercise patterns had a strong impact on modifiable 10-year cardiometabolic risk. (C) 2014 Wiley Periodicals, Inc.
C1 [Jacobsen, Henrik B.; Reme, Silje E.; Hopcia, Karen; Sorensen, Glorian; Buxton, Orfeu M.] Harvard Univ, Sch Publ Hlth, Ctr Work Hlth & Wellbeing, Boston, MA 02115 USA.
   [Jacobsen, Henrik B.; Stiles, Tore C.] Norwegian Univ Sci & Technol, N-7034 Trondheim, Norway.
   [Reme, Silje E.] Uni Res, Uni Hlth, Bergen, Norway.
   [Sembajwe, Grace] CUNY, Sch Publ Hlth, Hunter Coll, New York, NY 10021 USA.
   [Sembajwe, Grace; Hopcia, Karen] Partners Hlth Care Syst, Partners Occupat Hlth Serv, Boston, MA USA.
   [Sorensen, Glorian] Harvard Univ, Sch Publ Hlth, Dept Soc Hlth & Human Dev, Boston, MA 02115 USA.
   [Sorensen, Glorian] Dana Farber Canc Inst, Boston, MA 02115 USA.
   [Porter, James H.; Buxton, Orfeu M.] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA.
   [Marino, Miguel] Oregon Hlth & Sci Univ, Div Biostat, Dept Family Med Publ Hlth & Prevent Med, Portland, OR 97201 USA.
   [Buxton, Orfeu M.] Harvard Univ, Sch Med, Div Sleep Med, Boston, MA USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health; Norwegian
   University of Science & Technology (NTNU); City University of New York
   (CUNY) System; Hunter College (CUNY); Partners Healthcare System;
   Harvard University; Harvard T.H. Chan School of Public Health; Harvard
   University; Harvard University Medical Affiliates; Dana-Farber Cancer
   Institute; Harvard University; Harvard University Medical Affiliates;
   Brigham & Women's Hospital; Oregon Health & Science University; Harvard
   University; Harvard Medical School
RP Jacobsen, HB (corresponding author), NTNU, Fac Med, Dept Circulat & Med Imaging, POB 8905 MTFS, N-7491 Trondheim, Norway.
EM henrik.b.jacobsen@ntnu.no
RI Reme, Silje/K-5206-2018; Sembajwe, Grace/H-3288-2017
OI Stiles, Tore C./0000-0001-5853-6674; Sembajwe,
   Grace/0000-0002-7163-4743; Jacobsen, Henrik/0000-0001-5329-0003; Hopcia,
   Karen/0000-0001-9724-5634; Buxton, Orfeu/0000-0001-5057-633X
FU National Institute for Occupational Safety and Health [U19OH008861];
   National Center for Research Resources [UL1RR025758-04]; Work, Family,
   and Health Network [U01AG5186989]; National Heart, Lung, and Blood
   Institute [R01HL107240]; Dean Hashimoto and Partners Occupational Health
   Service
FX Contract grant sponsor: National Institute for Occupational Safety and
   Health; Contract grant number: U19OH008861; Contract grant sponsor:
   National Center for Research Resources. Grant number; Contract grant
   number: UL1RR025758-04; Contract grant sponsor: Work, Family, and Health
   Network; Contract grant number: U01AG5186989; Contract grant sponsor:
   National Heart, Lung, and Blood Institute; Contract grant number:
   R01HL107240; Contract grant sponsor: Dean Hashimoto and Partners
   Occupational Health Service.
CR Åkerstedt T, 2003, OCCUP MED-OXFORD, V53, P89, DOI 10.1093/occmed/kqg046
   [Anonymous], 2013, Behavioral Risk Factor Surveillance System Survey Questionnaire
   Ayas NT, 2003, DIABETES CARE, V26, P380, DOI 10.2337/diacare.26.2.380
   Ayas NT, 2003, ARCH INTERN MED, V163, P205, DOI 10.1001/archinte.163.2.205
   Backé EM, 2012, INT ARCH OCC ENV HEA, V85, P67, DOI 10.1007/s00420-011-0643-6
   Bellavia G.M., 2005, Handbook of work stress, P113, DOI DOI 10.4135/9781412975995.N6
   Berkman LF, 2010, J OCCUP HEALTH PSYCH, V15, P316, DOI 10.1037/a0019721
   Bhui KS, 2012, J ENVIRON PUBLIC HEA, V2012, DOI 10.1155/2012/515874
   Briones B, 1996, SLEEP, V19, P583, DOI 10.1093/sleep/19.7.583
   Bromley LE, 2012, SLEEP, V35, P977, DOI 10.5665/sleep.1964
   Brown DL, 2009, AM J EPIDEMIOL, V169, P1370, DOI 10.1093/aje/kwp056
   Buxton OM, 2012, J OCCUP ENVIRON MED, V54, P851, DOI 10.1097/JOM.0b013e31824e6913
   Buxton OM, 2010, SOC SCI MED, V71, P1027, DOI 10.1016/j.socscimed.2010.05.041
   Cappuccio FP, 2010, SLEEP, V33, P585, DOI 10.1093/sleep/33.5.585
   Chandola T, 2010, SLEEP, V33, P739, DOI 10.1093/sleep/33.6.739
   Chien KL, 2010, SLEEP, V33, P177, DOI 10.1093/sleep/33.2.177
   Cizza G, 2005, SLEEP, V28, P1217, DOI 10.1093/sleep/28.10.1217
   D'Agostino RB, 2008, CIRCULATION, V117, P743, DOI 10.1161/CIRCULATIONAHA.107.699579
   Dew MA, 2003, PSYCHOSOM MED, V65, P63, DOI 10.1097/01.PSY.0000039756.23250.7C
   Eller NH, 2009, CARDIOL REV, V17, P83, DOI 10.1097/CRD.0b013e318198c8e9
   Evans O, 2002, SOC SCI MED, V54, P481, DOI 10.1016/S0277-9536(01)00044-2
   Frone MR, 1997, J OCCUP ORGAN PSYCH, V70, P325, DOI 10.1111/j.2044-8325.1997.tb00652.x
   Frost P, 2009, SCAND J WORK ENV HEA, V35, P163, DOI 10.5271/sjweh.1319
   Gallicchio L, 2009, J SLEEP RES, V18, P148, DOI 10.1111/j.1365-2869.2008.00732.x
   Gangwisch JE, 2005, SLEEP, V28, P1289, DOI 10.1093/sleep/28.10.1289
   Gottlieb DJ, 2005, ARCH INTERN MED, V165, P863, DOI 10.1001/archinte.165.8.863
   Grandner MA, 2010, SLEEP MED REV, V14, P191, DOI 10.1016/j.smrv.2009.07.006
   Hale L, 2007, SLEEP, V30, P1096, DOI 10.1093/sleep/30.9.1096
   Harvey AG, 2011, CLIN PSYCHOL REV, V31, P225, DOI 10.1016/j.cpr.2010.04.003
   Hasler G, 2004, SLEEP, V27, P661, DOI 10.1093/sleep/27.4.661
   Hublin C, 2010, EUR J EPIDEMIOL, V25, P315, DOI 10.1007/s10654-010-9439-3
   Karasek R, 1998, J Occup Health Psychol, V3, P322, DOI 10.1037/1076-8998.3.4.322
   KARASEK RA, 1979, ADMIN SCI QUART, V24, P285, DOI 10.2307/2392498
   KAWACHI I, 1995, CIRCULATION, V92, P3178, DOI 10.1161/01.CIR.92.11.3178
   Kim SS, 2013, AM J IND MED, V56, P488, DOI 10.1002/ajim.22120
   Kivimäki M, 2012, LANCET, V380, P1491, DOI 10.1016/S0140-6736(12)60994-5
   Kohatsu ND, 2006, ARCH INTERN MED, V166, P1701, DOI 10.1001/archinte.166.16.1701
   Kripke DF, 2002, ARCH GEN PSYCHIAT, V59, P131, DOI 10.1001/archpsyc.59.2.131
   Laugsand L.E., 2013, European Heart Journal
   Lee IM, 2001, JAMA-J AM MED ASSOC, V285, P1447, DOI 10.1001/jama.285.11.1447
   Lusardi P, 1999, AM J HYPERTENS, V12, P63, DOI 10.1016/S0895-7061(98)00200-3
   Luyster FS, 2012, SLEEP, V35, P727, DOI 10.5665/sleep.1846
   Marino M, 2014, AM J PREV M IN PRESS
   Mathers C, 2008, GLOBAL BURDEN OF DISEASE: 2004 UPDATE, P1
   McKnight-Eily L. R., 2008, Morbidity and Mortality Weekly Report, V57, P200
   Meier-Ewert HK, 2004, J AM COLL CARDIOL, V43, P678, DOI 10.1016/j.jacc.2003.07.050
   Netemeyer RG, 1996, J APPL PSYCHOL, V81, P400, DOI 10.1037/0021-9010.81.4.400
   Newman AB, 2000, J AM GERIATR SOC, V48, P115, DOI 10.1111/j.1532-5415.2000.tb03901.x
   Ohayon MM, 2002, SLEEP MED REV, V6, P97, DOI 10.1053/smrv.2002.0186
   Patel SR, 2008, INT J OBESITY, V32, P1825, DOI 10.1038/ijo.2008.198
   Patel SR, 2004, SLEEP, V27, P440, DOI 10.1093/sleep/27.3.440
   Roger VL, 2011, CIRCULATION, V123, pE18, DOI 10.1161/CIR.0b013e3182009701
   Sattelmair J, 2011, CIRCULATION, V124, P789, DOI 10.1161/CIRCULATIONAHA.110.010710
   Schnall P., 2009, Unhealthy Work: Causes, Consequences, Cures
   Sorensen G, 2011, J OCCUP ENVIRON MED, V53, P899, DOI 10.1097/JOM.0b013e318226a74a
   Steptoe A, 2012, NAT REV CARDIOL, V9, P360, DOI 10.1038/nrcardio.2012.45
   Stranges S, 2010, J HYPERTENS, V28, P896, DOI 10.1097/HJH.0b013e328335d076
   Taheri S, 2004, PLOS MED, V1, P210, DOI 10.1371/journal.pmed.0010062
   US Department of Health and Human Services, 2010, FOC AR 7 ED COMM BAS
   Vgontzas AN, 2009, SLEEP, V32, P491, DOI 10.1093/sleep/32.4.491
   Weaver TE, 1997, SLEEP, V20, P835
   Wen CP, 2011, LANCET, V378, P1244, DOI 10.1016/S0140-6736(11)60749-6
   Wilson PWF, 1998, CIRCULATION, V97, P1837, DOI 10.1161/01.CIR.97.18.1837
   WINGARD DL, 1983, SLEEP, V6, P102, DOI 10.1093/sleep/6.2.102
   Yang H, 2006, HYPERTENSION, V48, P744, DOI 10.1161/01.HYP.0000238327.41911.52
NR 65
TC 24
Z9 28
U1 0
U2 31
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0271-3586
EI 1097-0274
J9 AM J IND MED
JI Am. J. Ind. Med.
PD AUG
PY 2014
VL 57
IS 8
BP 940
EP 949
DI 10.1002/ajim.22340
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA AM9EH
UT WOS:000340182800009
PM 24809311
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Gawlik-Kotelnicka, O
   Margulska, A
   Skowronska, A
   Strzelecki, D
AF Gawlik-Kotelnicka, Oliwia
   Margulska, Aleksandra
   Skowronska, Anna
   Strzelecki, Dominik
TI PRO-DEMET Randomized Controlled Trial on Probiotics in Depression-Pilot
   Study Results
SO NUTRIENTS
LA English
DT Article
DE depression; metabolic syndrome; probiotics; feasibility; pilot study
ID POSTMYOCARDIAL INFARCTION DEPRESSION; METABOLIC SYNDROME; GUT
   MICROBIOTA; PSYCHOMETRIC PROPERTIES; CONSENSUS STATEMENT; DOUBLE-BLIND;
   METAANALYSIS; DISORDER; SUPPLEMENTATION; ASSOCIATION
AB There is a pressing need to identify new treatment options for depression and its comorbidities. Depression often coexists with metabolic complications, and the two may share a pathophysiological overlap, including inflammation and microbiota changes. Microbiota interventions (e.g., probiotics) may represent a safe and easy-to-use treatment option as an adjunctive therapy in patients only partially responsive to pharmacologic treatment. (1) Objective: The paper presents the results of a feasibility and pilot study. The study is an internal part of a randomized controlled trail (RCT) of the effect of probiotic supplementation on psychometric, anthropometric, metabolic, and inflammatory parameters in adult patients with depressive disorders depending on the presence of metabolic syndrome. (2) Methods: The trial has a four-arm, parallel-group, prospective, randomized, double-blind, controlled design. Sixty participants received a probiotic preparation containing Lactobacillus helveticus Rosell(R)-52 and Bifidobacterium longum Rosell(R)-175 over 60 days. The feasibility of the study design was assessed, as well as the rates of recruitment, eligibility, consent, and study completion. The following were assessed: depressive, anxiety and stress symptoms, quality of life, blood pressure, body mass index and waist circumference, complete blood count with differential, serum levels of C-reactive protein, high-density lipoprotein cholesterol, triglycerides, fasting glucose, some secondary markers of inflammation and metabolic health, as well as noninvasive biomarkers of liver fibrosis (APRI and FIB-4). (3) Results: The study was found to be generally feasible. The eligibility rate was 52% of recruited participants with 80% completing the study protocol. No differences in sociodemographic or anthropometric factors or basic laboratory findings were found between the placebo and probiotic group at the start of the intervention period. Importantly, the proportion of recruited participants fulfilling the criteria of metabolic syndrome was too low. (4) Conclusions: Whilst the whole study protocol was feasible, some different timepoint procedures require modification. The major weakness of the recruitment methods was that the percentage of metabolic arms participants was insufficient. Overall, the full RCT design on probiotics in depression with vs. without metabolic syndrome was shown to be feasible with little modification.
C1 [Gawlik-Kotelnicka, Oliwia; Skowronska, Anna; Strzelecki, Dominik] Med Univ Lodz, Dept Affect & Psychot Disorders, PL-92216 Lodz, Poland.
   [Margulska, Aleksandra] Med Univ Lodz, Dept Adolescent Psychiat, PL-92216 Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz
RP Gawlik-Kotelnicka, O (corresponding author), Med Univ Lodz, Dept Affect & Psychot Disorders, PL-92216 Lodz, Poland.
EM oliwia.gawlik@umed.lodz.pl
RI Strzelecki, Dominik/S-9340-2016; Gawlik-Kotelnicka,
   Oliwia/ITU-7979-2023; Gawlik-Kotelnicka, Oliwia/S-9936-2016
OI Gawlik-Kotelnicka, Oliwia/0000-0003-1398-3117; Strzelecki,
   Dominik/0000-0002-8559-1078; Margulska, Aleksandra/0000-0003-1229-0925
FU Medical University of Lodz [503/1-155-02/503-11-003-20,
   502-03/1-155-02/502-14-386-18]
FX This research was funded by the Medical University of Lodz, grant number
   503/1-155-02/503-11-003-20 and 502-03/1-155-02/502-14-386-18.
CR Abbott JH, 2014, J ORTHOP SPORT PHYS, V44, P555, DOI 10.2519/jospt.2014.0110
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alli SR, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23094494
   [Anonymous], ICD 11
   Arseneault-Bréard J, 2012, BRIT J NUTR, V107, P1793, DOI 10.1017/S0007114511005137
   Belkaid Y, 2014, CELL, V157, P121, DOI 10.1016/j.cell.2014.03.011
   Brown TA, 1997, BEHAV RES THER, V35, P79, DOI 10.1016/S0005-7967(96)00068-X
   Carlessi AS, 2021, EUR J NEUROSCI, V53, P222, DOI 10.1111/ejn.14631
   Cazzola Mario, 2010, Ther Adv Respir Dis, V4, P259, DOI 10.1177/1753465810379009
   Chahwan B, 2019, J AFFECT DISORDERS, V253, P317, DOI 10.1016/j.jad.2019.04.097
   Chen JJ, 2011, EXP BIOL MED, V236, P823, DOI 10.1258/ebm.2011.010399
   Chodkiewicz J, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18073423
   Cocks K, 2013, J CLIN EPIDEMIOL, V66, P197, DOI 10.1016/j.jclinepi.2012.09.002
   Dabke K, 2019, J CLIN INVEST, V129, P4050, DOI 10.1172/JCI129194
   Dai X, 2020, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.567654
   Dash S, 2015, CURR OPIN PSYCHIATR, V28, P1, DOI 10.1097/YCO.0000000000000117
   Desai V, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.622181
   Dinan TG, 2017, GASTROENTEROL CLIN N, V46, P77, DOI 10.1016/j.gtc.2016.09.007
   Diop L, 2008, NUTR RES, V28, P1, DOI 10.1016/j.nutres.2007.10.001
   Dong Y, 2019, ANN NUTR METAB, V74, P224, DOI 10.1159/000499028
   Eldridge Sandra M, 2016, Pilot Feasibility Stud, V2, P64, DOI 10.1136/bmj.i5239
   Eslam M, 2020, J HEPATOL, V73, P202, DOI 10.1016/j.jhep.2020.03.039
   Gawlik-Kotelnicka O, 2021, PHARMACEUTICALS-BASE, V14, DOI 10.3390/ph14040384
   Gawlik-Kotelnicka O, 2021, J CLIN MED, V10, DOI 10.3390/jcm10071342
   Gerhard T, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0239206
   Ghorbani Z, 2018, ARCH NEUROSCI, V5, DOI 10.5812/archneurosci.60507
   Gilbert K, 2013, BRIT J NUTR, V109, P50, DOI 10.1017/S0007114512003807
   Goh KK, 2019, PSYCHIAT RES, V282, DOI 10.1016/j.psychres.2019.112568
   Hill C, 2014, NAT REV GASTRO HEPAT, V11, P506, DOI 10.1038/nrgastro.2014.66
   Huang RX, 2016, NUTRIENTS, V8, DOI 10.3390/nu8080483
   Kazemi A, 2019, J FUNCT FOODS, V52, P596, DOI 10.1016/j.jff.2018.11.041
   Koutnikova H, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2017-017995
   Lamers F, 2018, PSYCHOL MED, V48, P1102, DOI 10.1017/S0033291717002483
   Lamers F, 2020, BRAIN BEHAV IMMUN, V88, P174, DOI 10.1016/j.bbi.2020.04.002
   de Sequeira CL, 2022, NUTRIENTS, V14, DOI 10.3390/nu14030621
   Lee SH, 2018, J CLIN MED, V7, DOI 10.3390/jcm7090282
   Liskiewicz P, 2021, PROG NEURO-PSYCHOPH, V106, DOI 10.1016/j.pnpbp.2020.110076
   Liu RT, 2019, NEUROSCI BIOBEHAV R, V102, P13, DOI 10.1016/j.neubiorev.2019.03.023
   Lloyd-Price J, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0307-y
   Lof J, 2022, NEUROSCI BIOBEHAV R, V136, DOI 10.1016/j.neubiorev.2022.104634
   Madan A, 2020, J AFFECT DISORDERS, V264, P98, DOI 10.1016/j.jad.2019.12.020
   Marazziti D, 2014, CNS SPECTRUMS, V19, P293, DOI 10.1017/S1092852913000667
   Mason BL, 2020, J AFFECT DISORDERS, V266, P394, DOI 10.1016/j.jad.2020.01.137
   Matta J, 2019, J AFFECT DISORDERS, V244, P25, DOI 10.1016/j.jad.2018.09.072
   Messaoudi M, 2011, BRIT J NUTR, V105, P755, DOI 10.1017/S0007114510004319
   Miao ZH, 2022, BENEF MICROBES, V13, P407, DOI 10.3920/BM2021.0171
   Moazzami K, 2019, HEALTH PSYCHOL, V38, P586, DOI 10.1037/hea0000764
   MONTGOMERY SA, 1979, BRIT J PSYCHIAT, V134, P382, DOI 10.1192/bjp.134.4.382
   Montgomery SA, 2009, INT CLIN PSYCHOPHARM, V24, P111, DOI 10.1097/YIC.0b013e32832a8eb2
   Naseri K, 2023, EUR J NUTR, V62, P543, DOI 10.1007/s00394-022-03012-9
   Naseri K, 2022, PHARMACOL RES, V184, DOI 10.1016/j.phrs.2022.106399
   Ng QX, 2018, J AFFECT DISORDERS, V228, P13, DOI 10.1016/j.jad.2017.11.063
   Nikolova VL, 2021, J CLIN MED, V10, DOI 10.3390/jcm10040647
   Ortega MA, 2022, METABOLITES, V12, DOI 10.3390/metabo12010050
   Paul P, 2022, PHARMACOL RES, V185, DOI 10.1016/j.phrs.2022.106520
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Pinto-Sanchez MI, 2017, GASTROENTEROLOGY, V153, P448, DOI 10.1053/j.gastro.2017.05.003
   Reed GM, 2019, WORLD PSYCHIATRY, V18, P3, DOI 10.1002/wps.20611
   Romijn AR, 2017, AUST NZ J PSYCHIAT, V51, P810, DOI 10.1177/0004867416686694
   Salvucci E, 2019, HOW FERMENTED FOODS FEED A HEALTHY GUT MICROBIOTA: A NUTRITION CONTINUUM, P325, DOI 10.1007/978-3-030-28737-5_14
   Sanada K, 2020, J AFFECT DISORDERS, V266, P1, DOI 10.1016/j.jad.2020.01.102
   Sanchez-Rodriguez E, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030605
   Skevington SM, 2004, QUAL LIFE RES, V13, P299, DOI 10.1023/B:QURE.0000018486.91360.00
   Skonieczna-Zydecka K, 2018, J CLIN MED, V7, DOI 10.3390/jcm7120521
   Skowron K, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23147820
   Soto-Angona O, 2020, BMC MED, V18, DOI 10.1186/s12916-020-01713-8
   Tan JX, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.850014
   Tenorio-Jiménez C, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010124
   Thabane L, 2010, BMC MED RES METHODOL, V10, DOI 10.1186/1471-2288-10-1
   Thase ME, 2016, EUR NEUROPSYCHOPHARM, V26, P979, DOI 10.1016/j.euroneuro.2016.03.007
   Trifkovic KC, 2022, HEALTHCARE-BASEL, V10, DOI 10.3390/healthcare10060970
   Vallianou N, 2019, CURR OBES REP, V8, P317, DOI 10.1007/s13679-019-00352-2
   Vila AV, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-019-14177-z
   Wadolowska L., 2005, Bromatologia i Chemia Toksykologiczna, V38, P27
   Yang Q, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020381
   Yu HR, 2022, NUTRIENTS, V14, DOI 10.3390/nu14194004
   Alamdary SZ, 2022, INT J CLIN PRACT, V2022, DOI 10.1155/2022/5963679
   Zeng LT, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.961325
   Ziebold C, 2019, PSYCHOL MED, V49, P764, DOI 10.1017/S0033291718001381
NR 79
TC 7
Z9 7
U1 7
U2 23
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2023
VL 15
IS 6
AR 1400
DI 10.3390/nu15061400
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA C0MV5
UT WOS:000958973900001
PM 36986132
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Guedes, EP
   Madeira, E
   Mafort, TT
   Madeira, M
   Moreira, RO
   Mendonça, LMC
   Godoy-Matos, AF
   Lopes, AJ
   Farias, MLF
AF Guedes, Erika P.
   Madeira, Eduardo
   Mafort, Thiago T.
   Madeira, Miguel
   Moreira, Rodrigo O.
   Mendonca, Laura Maria C.
   Godoy-Matos, Amelio F.
   Lopes, Agnaldo J.
   Farias, Maria Lucia F.
TI Impact of a 6-month treatment with intragastric balloon on body
   composition and psychopathological profile in obese individuals with
   metabolic syndrome
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Obesity; Depression; Anxiety; Body composition; Intragastric balloon
ID QUALITY-OF-LIFE; BEHAVIORAL WEIGHT-LOSS; X-RAY ABSORPTIOMETRY; BARIATRIC
   SURGERY; DEPRESSIVE SYMPTOMS; MORBID-OBESITY; MASS INDEX; MOOD
   DISORDERS; ANXIETY; WOMEN
AB Background: The aim of this study was to investigate the effects of a 6-month treatment with intragastric balloon (IGB) on body composition and depressive/anxiety symptoms in obese individuals with metabolic syndrome (MS).
   Methods: Fifty patients (aged 18-50 years) with obesity and MS were selected for treatment with IGB for 6 months. Body composition was verified with dual-energy X-ray absorptiometry (DXA) at baseline and right after IGB removal. Anxiety/depressive symptoms were assessed with the Beck Depression Inventory (BDI) and the hospital anxiety and depression scale (HADS) at baseline and after 6 months of treatment.
   Results: In total, 39 patients completed the study. After 6 months, there were significant decreases in weight (11.7 +/- 9.6 kg, p < 0.0001) and waist circumference (9.3 +/- 8.2 cm, p < 0.0001). Weight loss was also demonstrated by DXA and corresponded to decreases of 3.0 +/- 3.4% in body fat percentage, 7.53 +/- 7.62 kg in total body fat, and 3.70 +/- 4.89 kg in lean body mass (p < 0.001 for all comparisons). Depressive symptoms scores decreased by a mean of 4.57 +/- 10.6 points when assessed with the BDI (p = 0.002) and 1.82 +/- 5.16 points when assessed with the HADS-Depression (p = 0.0345). Anxiety symptoms scores decreased by a mean of 1.84 +/- 4.04 points when determined with the HADS-anxiety (p = 0.0066). The decrease in body fat percentage was the parameter that best correlated with improvements in depressive (p = 0.008) and anxiety symptoms (p = 0.014).
   Conclusions: In obese individuals with MS, fat mass reduction was associated with short-term improvements in depressive and anxiety symptoms.
C1 [Guedes, Erika P.; Moreira, Rodrigo O.; Godoy-Matos, Amelio F.] State Inst Diabet & Endocrinol IEDE, Div Metabol, Rua Moncorvo Filho 90 Ctr, BR-20211340 Rio De Janeiro, RJ, Brazil.
   [Guedes, Erika P.; Madeira, Eduardo; Madeira, Miguel; Moreira, Rodrigo O.; Farias, Maria Lucia F.] Univ Fed Rio de Janeiro, Div Endocrinol, Rio De Janeiro, Brazil.
   [Madeira, Eduardo] Univ Estado Rio De Janeiro, Div Gastroenterol, Rio De Janeiro, Brazil.
   [Mafort, Thiago T.; Lopes, Agnaldo J.] Univ Estado Rio De Janeiro, Div Pulmonol, Rio De Janeiro, Brazil.
   [Mendonca, Laura Maria C.] Univ Fed Rio de Janeiro, Div Rheumatol, Rio De Janeiro, Brazil.
C3 Universidade Federal do Rio de Janeiro; Universidade do Estado do Rio de
   Janeiro; Universidade do Estado do Rio de Janeiro; Universidade Federal
   do Rio de Janeiro
RP Guedes, EP (corresponding author), State Inst Diabet & Endocrinol IEDE, Div Metabol, Rua Moncorvo Filho 90 Ctr, BR-20211340 Rio De Janeiro, RJ, Brazil.
EM erikapaniago@uol.com.br
RI Lopes, Agnaldo/B-6430-2016; Moreira, Rodrigo/N-7131-2015; Lopes, Agnaldo
   Jose/AAB-5944-2019
OI Guedes, ERIKA/0000-0003-4430-8069; Lopes, Agnaldo
   Jose/0000-0001-8598-4878; Godoy-Matos, Amelio/0000-0001-9089-9889
CR [Anonymous], INT J OBES LOND
   [Anonymous], 2005, IDF CONS WORLDW DEF
   Atlantis E, 2008, INT J OBESITY, V32, P881, DOI 10.1038/ijo.2008.54
   Botega NJ, 1995, REV SAUDE PUBL, V29, P355, DOI 10.1590/S0034-89101995000500004
   Busch AM, 2013, OBESITY, V21, pE211, DOI 10.1002/oby.20113
   Buzga M, 2014, OBES SURG, V24, P909, DOI 10.1007/s11695-014-1191-4
   Carbonelli MG, 2003, ACTA DIABETOL, V40, pS261, DOI 10.1007/s00592-003-0081-3
   Coin A, 2008, CLIN NUTR, V27, P87, DOI 10.1016/j.clnu.2007.10.008
   Cugini P, 1999, Eat Weight Disord, V4, P115
   Dekker MJHJ, 2012, J CLIN ENDOCR METAB, V97, pE233, DOI 10.1210/jc.2011-0601
   Deliopoulou K, 2013, OBES SURG, V23, P669, DOI 10.1007/s11695-012-0855-1
   Doldi SB, 2004, HEPATO-GASTROENTEROL, V51, P294
   Fabricatore AN, 2011, INT J OBESITY, V35, P1363, DOI 10.1038/ijo.2011.2
   Faulconbridge LF, 2013, SURG OBES RELAT DIS, V9, P790, DOI 10.1016/j.soard.2012.10.010
   Faulconbridge LF, 2012, OBESITY, V20, P783, DOI 10.1038/oby.2011.315
   Faulconbridge LF, 2009, OBESITY, V17, P1009, DOI 10.1038/oby.2008.647
   Folini L, 2014, ACTA DIABETOL, V51, P361, DOI 10.1007/s00592-013-0516-4
   Genco A, 2006, INT J OBESITY, V30, P129, DOI 10.1038/sj.ijo.0803094
   Gorenstein C, 1999, J CLIN PSYCHOL, V55, P553, DOI 10.1002/(SICI)1097-4679(199905)55:5<553::AID-JCLP3>3.0.CO;2-D
   Green EA, 2009, TECH REP SER, V68, P791
   Grilo CM, 2013, BEHAV RES THER, V51, P167, DOI 10.1016/j.brat.2013.01.002
   Guedes EP, 2013, DIABETOL METAB SYNDR, V5, DOI 10.1186/1758-5996-5-82
   Guisado JA, 2002, OBES SURG, V12, P835, DOI 10.1381/096089202320995664
   Hillman JB, 2010, CLIN PEDIATR, V49, P671, DOI 10.1177/0009922810363155
   Jauch-Chara K, 2014, PROG NEUROBIOL, V114, P84, DOI 10.1016/j.pneurobio.2013.12.001
   Kiortsis DN, 2008, NUTR METAB CARDIOVAS, V18, P207, DOI 10.1016/j.numecd.2006.10.003
   Lasikiewicz N, 2014, APPETITE, V72, P123, DOI 10.1016/j.appet.2013.09.017
   LIPOWSKI ZJ, 1988, AM J PSYCHIAT, V145, P1358
   Lopresti AL, 2013, PROG NEURO-PSYCHOPH, V45, P92, DOI 10.1016/j.pnpbp.2013.05.005
   Maddi SR, 2001, OBES SURG, V11, P680, DOI 10.1381/09608920160558605
   Mafort TT, 2014, OBES SURG, V24, P232, DOI 10.1007/s11695-013-1061-5
   Marcolino José Álvaro Marques, 2007, Rev. Bras. Anestesiol., V57, P157, DOI 10.1590/S0034-70942007000200004
   Martinez-Rocca MA, 2007, OBES SURG, V17, P649, DOI 10.1007/s11695-007-9109-z
   Masheb RM, 2007, COMPR PSYCHIAT, V48, P231, DOI 10.1016/j.comppsych.2007.01.005
   Mathus-Vliegen EMH, 2010, NAT REV GASTRO HEPAT, V7, P7, DOI 10.1038/nrgastro.2009.214
   Moreira RO, 2007, EAT WEIGHT DISORD-ST, V12, P35
   Pais-Ribeiro J, 2010, PSYCHOL HEALTH MED, V12, P225
   Papelbaum M, 2010, REV BRAS PSIQUIATR, V32, P42, DOI 10.1590/S1516-44462010000100009
   Preiss K, 2013, OBES REV, V14, P906, DOI 10.1111/obr.12052
   Sachs-Ericsson N, 2007, AM J GERIAT PSYCHIAT, V15, P815, DOI 10.1097/JGP.0b013e3180a725d6
   Sallet JA, 2004, OBES SURG, V14, P991, DOI 10.1381/0960892041719671
   Sarwer DB, 2005, OBES RES, V13, P639, DOI 10.1038/oby.2005.71
   Shuster A, 2000, BRIT J RADIOL, V85, P1
   Strain GW, 2014, NUTR DIABETES, V4, DOI 10.1038/nutd.2014.29
   Stunkard AJ, 2003, BIOL PSYCHIAT, V54, P330, DOI 10.1016/S0006-3223(03)00608-5
   Thonney B, 2010, AM J SURG, V199, P183, DOI 10.1016/j.amjsurg.2008.12.028
   van Hout GCM, 2006, OBES SURG, V16, P787, DOI 10.1381/096089206777346808
   Zago S, 2006, Minerva Med, V97, P51
   Zhao G, 2009, INT J OBESITY, V33, P257, DOI 10.1038/ijo.2008.268
   Zhong WJ, 2010, DEPRESS ANXIETY, V27, P846, DOI 10.1002/da.20666
NR 50
TC 8
Z9 9
U1 0
U2 13
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD DEC 19
PY 2016
VL 8
AR 81
DI 10.1186/s13098-016-0197-6
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EG1TG
UT WOS:000390814600001
PM 28031749
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fulop, T
   Tessier, D
   Carpentier, A
AF Fulop, T.
   Tessier, D.
   Carpentier, A.
TI The metabolic syndrome
SO PATHOLOGIE BIOLOGIE
LA English
DT Review
DE insulin resistance; obesity; inflammation; adipose tissue; cytokines;
   aging innate immunity
ID TUMOR-NECROSIS-FACTOR; C-REACTIVE PROTEIN; ENDOPLASMIC-RETICULUM STRESS;
   INSULIN-RESISTANCE SYNDROME; PANEL-III CRITERIA; ADIPOSE-TISSUE;
   SKELETAL-MUSCLE; INFLAMMATORY MARKERS; OXIDATIVE STRESS; FATTY-ACIDS
AB The metabolic syndrome (MS) is a cluster of metabolic abnormalities leading to increased risk for cardiovascular diseases and diabetes type 2. Its prevalence is increasing with aging. There exists actually an epidemic of MS. Visceral obesity and the resulting insulin resistance (IR) are the major determinant in the development of the MS. Abdominal obesity results in a low grade inflammation via the adipose tissue and macrophages secreted adipokines. This inflammation, via the generated pro-inflammatory molecules, interferes with the normal insulin signalling and thus contributes to the etiopathogenesis of the MS. Large clinical studies showed that CRP is increased in obese subjects and concomitantly to the number of existing component of the MS. Treatment of the MS is aimed to improve the IR by lifestyle changes including exercise and diet alone or in combination with medication targeting the individual components but having also anti-inflammatory actions.. More research is needed to bring new therapies to be able to decrease the incidence and prevalence of the MS among the population and thus increasing their quality of life. (c) 2006 Elsevier Masson SAS. All rights reserved.
C1 Univ Sherbrooke, Res Ctr Aging, Grad Program Immunol, Fac Med, 1036 Rue Blevedere Sud, Sherbrooke, PQ J1H 4C4, Canada.
   Univ Sherbrooke, Div Geriatr, Fac Med, Sherbrooke, PQ J1H 4C4, Canada.
   Univ Sherbrooke, Clin Res Ctr, Fac Med, Sherbrooke, PQ J1H 4C4, Canada.
   Univ Sherbrooke, Div Endocrinol, Fac Med, Sherbrooke, PQ J1H 4C4, Canada.
C3 University of Sherbrooke; University of Sherbrooke; University of
   Sherbrooke; University of Sherbrooke
RP Fulop, T (corresponding author), Univ Sherbrooke, Res Ctr Aging, Grad Program Immunol, Fac Med, 1036 Rue Blevedere Sud, Sherbrooke, PQ J1H 4C4, Canada.
EM tamas.fulop@usherbrooke.ca
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   *AM COLL END TASK, 2003, ENDOCR PRACT, V9, P236
   [Anonymous], 2004, IDF CONS WORLDW DEF
   Arner P, 2001, DIABETES OBES METAB, V3, pS11, DOI 10.1046/j.1463-1326.2001.00031.x
   Athyros VG, 2005, ATHEROSCLEROSIS, V183, P187, DOI 10.1016/j.atherosclerosis.2005.06.029
   Bacha F, 2003, J CLIN ENDOCR METAB, V88, P2534, DOI 10.1210/jc.2002-021267
   Bartke A, 2006, TRENDS ENDOCRIN MET, V17, P33, DOI 10.1016/j.tem.2006.01.002
   Barzilai N, 2003, JAMA-J AM MED ASSOC, V290, P2030, DOI 10.1001/jama.290.15.2030
   Bechtold Matthew, 2006, Curr Diab Rep, V6, P64, DOI 10.1007/s11892-006-0054-3
   Berg AH, 2002, TRENDS ENDOCRIN MET, V13, P84, DOI 10.1016/S1043-2760(01)00524-0
   Bernardi R, 2006, Minerva Med, V97, P123
   Björnholm M, 2005, BIOCHEM SOC T, V33, P354
   Boehm BO, 2005, SCAND J CLIN LAB INV, V65, P3, DOI 10.1080/00365510500236044
   BONADONNA RC, 1993, J CLIN INVEST, V92, P486, DOI 10.1172/JCI116592
   Bonora E, 2006, ANN MED, V38, P64, DOI 10.1080/07853890500401234
   Browning LM, 2006, DIABETES TECHNOL THE, V8, P45, DOI 10.1089/dia.2006.8.45
   Carr DB, 2004, DIABETES, V53, P2087, DOI 10.2337/diabetes.53.8.2087
   Charrière G, 2003, J BIOL CHEM, V278, P9850, DOI 10.1074/jbc.M210811200
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Colca JR, 2006, BIOCHEM PHARMACOL, V72, P125, DOI 10.1016/j.bcp.2006.01.002
   Craft S, 2005, NEUROBIOL AGING, V26, pS65, DOI 10.1016/j.neurobiolaging.2005.08.021
   DELPRATO S, 1994, DIABETOLOGIA, V37, P1025, DOI 10.1007/BF00400466
   Després JP, 2006, ANN MED, V38, P52, DOI 10.1080/07853890500383895
   DESPRES JP, 1989, DIABETES, V38, P304, DOI 10.2337/diabetes.38.3.304
   Duncan BB, 2006, DIABETES TECHNOL THE, V8, P7, DOI 10.1089/dia.2006.8.7
   Egan BM, 2005, AM J HYPERTENS, V18, P3, DOI 10.1016/j.amjhyper.2004.08.008
   ENDRES S, 1989, NEW ENGL J MED, V320, P265, DOI 10.1056/NEJM198902023200501
   Fantuzzi G, 2005, J ALLERGY CLIN IMMUN, V115, P911, DOI 10.1016/j.jaci.2005.02.023
   Ferrannini E, 1997, HYPERTENSION, V30, P1144, DOI 10.1161/01.HYP.30.5.1144
   Ferrannini E, 2006, ANN MED, V38, P42, DOI 10.1080/07853890500415358
   FERRANNINI E, 1983, J CLIN INVEST, V72, P1737, DOI 10.1172/JCI111133
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Franceschi C, 2005, MECH AGEING DEV, V126, P351, DOI 10.1016/j.mad.2004.08.028
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gastaldelli A, 2005, DIABETOLOGIA, V48, P2090, DOI 10.1007/s00125-005-1891-3
   Gastaldelli A, 2000, DIABETES, V49, P1367, DOI 10.2337/diabetes.49.8.1367
   Gavin JR, 1997, DIABETES CARE, V20, P1183
   Gil-Campos M, 2004, CLIN NUTR, V23, P963, DOI 10.1016/j.clnu.2004.04.010
   Giles Thomas D, 2005, J Clin Hypertens (Greenwich), V7, P669, DOI 10.1111/j.1524-6175.2005.04763.x
   Gimeno RE, 2005, CURR OPIN PHARMACOL, V5, P122, DOI 10.1016/j.coph.2005.01.006
   Ginsberg HN, 2002, CIRCULATION, V106, P2137, DOI 10.1161/01.CIR.0000035280.64322.31
   GOLAY A, 1987, METABOLISM, V36, P692, DOI 10.1016/0026-0495(87)90156-9
   Goodpaster BH, 2002, CURR OPIN CLIN NUTR, V5, P481, DOI 10.1097/00075197-200209000-00005
   GROOP LC, 1991, J CLIN ENDOCR METAB, V72, P96, DOI 10.1210/jcem-72-1-96
   Grundy SM, 2005, CLIN CHEM, V51, P1352, DOI 10.1373/clinchem.2005.050989
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Haffner SM, 2006, AM J CARDIOL, V97, p3A, DOI 10.1016/j.amjcard.2005.11.010
   Hak AE, 1999, ARTERIOSCL THROM VAS, V19, P1986, DOI 10.1161/01.ATV.19.8.1986
   Hashizume K, 2006, MECH AGEING DEV, V127, P507, DOI 10.1016/j.mad.2006.01.026
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   HOTAMISLIGIL GS, 1995, J CLIN INVEST, V95, P2409, DOI 10.1172/JCI117936
   Hughes KA, 2005, ANNU REV ENTOMOL, V50, P421, DOI 10.1146/annurev.ento.50.071803.130409
   Hutley L, 2005, AM J MED SCI, V330, P280, DOI 10.1097/00000441-200512000-00005
   Ito H, 2002, CLIN EXP PHARMACOL P, V29, P399, DOI 10.1046/j.1440-1681.2002.03672.x
   Iwashima Y, 2004, HYPERTENSION, V43, P1318, DOI 10.1161/01.HYP.0000129281.03801.4b
   Janssen I, 2005, J NUTR HEALTH AGING, V9, P408
   Kahn BB, 2000, J CLIN INVEST, V106, P473, DOI 10.1172/JCI10842
   KISSEBAH AH, 1989, DIABETES METAB REV, V5, P83, DOI 10.1002/dmr.5610050202
   Klein-Platat C, 2005, AM J CLIN NUTR, V82, P1178, DOI 10.1093/ajcn/82.6.1178
   Knowler WC, 2002, NEW ENGL J MED, V346, P393, DOI 10.1056/nejmoa012512
   Koh KK, 2005, J AM COLL CARDIOL, V46, P1978, DOI 10.1016/j.jacc.2005.06.082
   Kolb H, 2005, DIABETOLOGIA, V48, P1038, DOI 10.1007/s00125-005-1764-9
   Kovacs P, 2005, BEST PRACT RES CL EN, V19, P625, DOI 10.1016/j.beem.2005.07.003
   Kralisch S, 2005, J ENDOCRINOL, V185, pR1, DOI 10.1677/joe.1.06211
   Kylin E., 1923, Zentralbl Inn Med, V44, P105
   Laakso M, 2006, ANN MED, V38, P32, DOI 10.1080/07853890500457558
   Laron Z, 2005, MECH AGEING DEV, V126, P305, DOI 10.1016/j.mad.2004.08.022
   Lau DCW, 2006, CAN J CARDIOL, V22, p85B, DOI 10.1016/S0828-282X(06)70992-8
   Lee JY, 2006, MOL CELLS, V21, P174
   Lemieux I, 2000, CIRCULATION, V102, P179, DOI 10.1161/01.CIR.102.2.179
   Liao YL, 2004, DIABETES CARE, V27, P978, DOI 10.2337/diacare.27.4.978
   Lyon CJ, 2003, ENDOCRINOLOGY, V144, P2195, DOI 10.1210/en.2003-0285
   Magliano DJ, 2006, ANN MED, V38, P34, DOI 10.1080/07853890500300311
   Makowski L, 2001, NAT MED, V7, P699, DOI 10.1038/89076
   Matsuda M, 2002, J BIOL CHEM, V277, P37487, DOI 10.1074/jbc.M206083200
   Montagnani M, 2002, MOL ENDOCRINOL, V16, P1931, DOI 10.1210/me.2002-0074
   Morley JE, 2004, J GERONTOL A-BIOL, V59, P139
   Murdolo G, 2006, NUTR METAB CARDIOVAS, V16, pS35, DOI 10.1016/j.numecd.2005.10.016
   Nakatani Y, 2005, J BIOL CHEM, V280, P847, DOI 10.1074/jbc.M411860200
   *NCEP, 2003, DIABETES, V52, P1210
   Ogihara T, 2004, DIABETOLOGIA, V47, P794, DOI 10.1007/s00125-004-1391-x
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Pawelec G, 2005, IMMUNOL REV, V205, P257, DOI 10.1111/j.0105-2896.2005.00271.x
   Perseghin G, 2003, INT J OBESITY, V27, pS6, DOI 10.1038/sj.ijo.0802491
   Pickup JC, 1997, DIABETOLOGIA, V40, P1286, DOI 10.1007/s001250050822
   Pickup JC, 2006, DIABETES TECHNOL THE, V8, P1, DOI 10.1089/dia.2006.8.1
   Plomgaard P, 2005, DIABETES, V54, P2939, DOI 10.2337/diabetes.54.10.2939
   Plutzky J, 2004, REV ENDOCR METAB DIS, V5, P255, DOI 10.1023/B:REMD.0000032414.17672.5c
   Porter MH, 2002, J LAB CLIN MED, V139, P140, DOI 10.1067/mlc.2002.121552
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Resnick HE, 2003, DIABETES CARE, V26, P861, DOI 10.2337/diacare.26.3.861
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   Rincon M, 2005, EXP GERONTOL, V40, P873, DOI 10.1016/j.exger.2005.06.014
   Ruan H, 2004, CURR OPIN LIPIDOL, V15, P297, DOI 10.1097/00041433-200406000-00009
   Ruan H, 2003, CYTOKINE GROWTH F R, V14, P447, DOI 10.1016/S1359-6101(03)00052-2
   Santos AC, 2005, INT J OBESITY, V29, P1452, DOI 10.1038/sj.ijo.0803035
   Schernthaner GH, 2005, SCAND J CLIN LAB INV, V65, P30, DOI 10.1080/00365510500236119
   Schinner S, 2005, DIABETIC MED, V22, P674, DOI 10.1111/j.1464-5491.2005.01566.x
   Senn JJ, 2003, J BIOL CHEM, V278, P13740, DOI 10.1074/jbc.M210689200
   Shaw Sidney G., 2005, Current Vascular Pharmacology, V3, P359, DOI 10.2174/157016105774329471
   Shepherd PR, 2005, ACTA PHYSIOL SCAND, V183, P3, DOI 10.1111/j.1365-201X.2004.01382.x
   Shimabukuro M, 2003, J CLIN ENDOCR METAB, V88, P3236, DOI 10.1210/jc.2002-021883
   Sonnenberg GE, 2004, OBES RES, V12, P180, DOI 10.1038/oby.2004.24
   Stefan N, 2002, HORM METAB RES, V34, P469, DOI 10.1055/s-2002-34785
   Steinberg HO, 2002, DIABETOLOGIA, V45, P623, DOI 10.1007/s00125-002-0800-2
   Taskinen MR, 2005, CURR MOL MED, V5, P297, DOI 10.2174/1566524053766086
   Troseid M, 2004, EUR HEART J, V25, P349, DOI 10.1016/j.ehj.2003.12.006
   Tuomilehto Jaakko, 2001, New England Journal of Medicine, V344, P1343, DOI 10.1056/NEJM200105033441801
   Tzeng TF, 2005, DIABETOLOGIA, V48, P1386, DOI 10.1007/s00125-005-1791-6
   Ueno M, 2005, DIABETOLOGIA, V48, P506, DOI 10.1007/s00125-004-1662-6
   Vettor R, 2005, ALIMENT PHARM THER, V22, P3, DOI 10.1111/j.1365-2036.2005.02587.x
   Virtanen KA, 2005, DIABETES, V54, P2720, DOI 10.2337/diabetes.54.9.2720
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   White David W., 1996, Cytokine and Growth Factor Reviews, V7, P303, DOI 10.1016/S1359-6101(96)00040-8
   White MF, 1997, DIABETOLOGIA, V40, pS2, DOI 10.1007/s001250051387
   Wyne KL, 2006, DIABETES OBES METAB, V8, P365, DOI 10.1111/j.1463-1326.2005.00522.x
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yang J, 2005, EXP GERONTOL, V40, P867, DOI 10.1016/j.exger.2005.08.001
   Yudkin JS, 1999, ARTERIOSCL THROM VAS, V19, P972, DOI 10.1161/01.ATV.19.4.972
   Zambon A, 2005, ALIMENT PHARM THER, V22, P20, DOI 10.1111/j.1365-2036.2005.02589.x
   Zick Y, 2004, BIOCHEM SOC T, V32, P812, DOI 10.1042/BST0320812
   Zimmet P, 2001, NATURE, V414, P782, DOI 10.1038/414782a
NR 124
TC 108
Z9 129
U1 0
U2 8
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0369-8114
J9 PATHOL BIOL
JI Pathol. Biol.
PD SEP
PY 2006
VL 54
IS 7
BP 375
EP 386
DI 10.1016/j.patbio.2006.07.002
PG 12
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA 097CO
UT WOS:000241424200002
PM 16904849
DA 2025-06-11
ER

PT J
AU Dehesh, T
   Mosleh-Shirazi, MA
   Dehesh, P
AF Dehesh, Tania
   Mosleh-Shirazi, Mohammad Amin
   Dehesh, Paria
TI Prevalence and associated factors of anxiety and depression among
   patients with hypothyroidism in Southern Iran
SO BMC PSYCHIATRY
LA English
DT Article
DE Anxiety; Depression; Hypothyroidism; Hamilton questionnaire; Beck
   questionnaire
ID METABOLIC SYNDROME; POPULATION; DISORDERS
AB PurposeDepression and anxiety are the main disorders in patients suffering from hypothyroidism. These disorders can lead to increased patient suffering. Since hypothyroidism is one of the most prevalent endocrine diseases, controlling the metabolic variables that increase the severity of anxiety and depression is important. This study aimed to assess the prevalence of anxiety and depression and to identify their associated factors, including metabolic variables, among people with hypothyroidism.Patients and methodsWe performed a cross-sectional study of 1,600 patients with hypothyroidism in Kerman, the southern part of Iran. The prevalence of depression and anxiety was estimated using the Beck Depression Inventory and the Hamilton Anxiety questionnaires, respectively. First, univariate logistic regression was performed. Factors whose P-values were smaller than 0.2 in univariate logistic regression were included in multiple logistic regression for confounder adjustments. The analysis was performed using SPSS version 20.ResultsThe rates of depression and anxiety were 59% (95% CI: 53.18-62.11) and 63% (95% CI: 58.42-67.22), respectively. Factors found to be independently associated with anxiety were high TSH, high LDL, high TG, high FBS, high TGAb, high TPoAb, high TC, and hypertension. For depression, high TSH, high LDL, high TG, high FBS, high TC, and hypertension were identified. High TGAb and high TPoAb were independently associated with anxiety but not with depression.ConclusionsStudy findings revealed that a large proportion of patients with hypothyroidism suffer from depression and anxiety. This study also identified factors associated with these disorders. Controlling some metabolic variables may decrease the prevalence and severity of these disorders, help patients with better treatment, and improve their quality of life.
C1 [Dehesh, Tania] Kerman Univ Med Sci, Inst Futures Studies Hlth, Modeling Hlth Res Ctr, Kerman, Iran.
   [Dehesh, Paria] Kerman Univ Med Sci, Inst Futures Studies Hlth, Social Determinants Hlth Res Ctr, Kerman, Iran.
   [Mosleh-Shirazi, Mohammad Amin] Shiraz Univ Med Sci, Ionizing & Nonionizing Radiat Protect Res Ctr INIR, Sch Paramed Sci, Shiraz, Iran.
   [Mosleh-Shirazi, Mohammad Amin] Shiraz Univ Med Sci, Sch Med, Dept Radiooncol, Shiraz, Iran.
   [Dehesh, Tania; Dehesh, Paria] Kerman Univ Med Sci, Sch Publ Hlth, Dept Biostat & Epidemiol, Kerman, Iran.
C3 Kerman University of Medical Sciences; Kerman University of Medical
   Sciences; Shiraz University of Medical Science; Shiraz University of
   Medical Science; Kerman University of Medical Sciences
RP Dehesh, P (corresponding author), Kerman Univ Med Sci, Inst Futures Studies Hlth, Social Determinants Hlth Res Ctr, Kerman, Iran.; Dehesh, P (corresponding author), Kerman Univ Med Sci, Sch Publ Hlth, Dept Biostat & Epidemiol, Kerman, Iran.
EM Paria_dehesh@yahoo.com
RI Mosleh-Shirazi, Mohammad/L-9212-2016; Dehesh, Tania/AAN-9801-2020
CR Abbasi Shavazi M., 2010, J Popul Association Iran, V5, P77
   Aminorroaya A, 2017, EUR J MED RES, V22, DOI 10.1186/s40001-017-0260-2
   Bagherniya M, 2017, DIABETES METAB SYND, V11, pS561, DOI 10.1016/j.dsx.2017.04.005
   Bathla Manish, 2016, Indian J Endocrinol Metab, V20, P468, DOI 10.4103/2230-8210.183476
   Bjelland I, 2002, J PSYCHOSOM RES, V52, P69, DOI 10.1016/S0022-3999(01)00296-3
   Caro J, 2013, ENDOCRINOL NUTR, V60, P167, DOI 10.1016/j.endonu.2012.11.004
   Chakera AJ, 2011, DRUG DES DEV THER, V6, P1, DOI 10.2147/DDDT.S12894
   Chang CH, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-07004-2
   Chiovato L, 2019, ADV THER, V36, P47, DOI 10.1007/s12325-019-01080-8
   Contreras F, 2007, J AFFECT DISORDERS, V100, P65, DOI 10.1016/j.jad.2006.09.021
   Duñabeitia I, 2023, SCAND J CLIN LAB INV, V83, P523, DOI 10.1080/00365513.2023.2286651
   Fugger G, 2018, EUR NEUROPSYCHOPHARM, V28, P752, DOI 10.1016/j.euroneuro.2018.03.011
   Ge JF, 2016, FRONT ENDOCRINOL, V7, DOI 10.3389/fendo.2016.00044
   Ghassemzadeh H, 2005, DEPRESS ANXIETY, V21, P185, DOI 10.1002/da.20070
   Gupta Soma, 2008, J Indian Med Assoc, V106, P242
   Hall RC, 1986, Integrative psychiatry
   HALL RCW, 1983, PSYCHOSOMATICS, V24, P7, DOI 10.1016/S0033-3182(83)73255-X
   Han KM, 2019, J AFFECT DISORDERS, V257, P486, DOI 10.1016/j.jad.2019.07.003
   Haneklaus M, 2015, IMMUNOL REV, V265, P53, DOI 10.1111/imr.12285
   Haug TT, 2004, PSYCHOSOM MED, V66, P845, DOI 10.1097/01.psy.0000145823.85658.0c
   He JJ, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.661160
   Hermann D, 2002, ADDICTION, V97, P1369, DOI 10.1046/j.1360-0443.2002.00200.x
   Hough CM, 2021, PSYCHOL MED, V51, P2117, DOI 10.1017/S0033291720000896
   Kim MD, 2020, J AFFECT DISORDERS, V264, P494, DOI 10.1016/j.jad.2019.11.080
   Kühner C, 2007, NERVENARZT, V78, P651, DOI 10.1007/s00115-006-2098-7
   Lang XE, 2020, J AFFECT DISORDERS, V263, P507, DOI 10.1016/j.jad.2019.11.004
   Liu HX, 2022, ENDOCR CONNECT, V11, DOI 10.1530/EC-21-0002
   Liu WT, 2022, BOSNIAN J BASIC MED, V22, P635, DOI 10.17305/bjbms.2021.6754
   Loh HH, 2019, BMC PSYCHIATRY, V19, DOI 10.1186/s12888-018-2006-2
   MALDONADO G, 1993, AM J EPIDEMIOL, V138, P923, DOI 10.1093/oxfordjournals.aje.a116813
   Mikulska AA, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23126580
   Mohammad MYH, 2019, J FAM MED PRIM CARE, V8, P2708, DOI 10.4103/jfmpc.jfmpc_456_19
   Park JH, 2021, EUR CHILD ADOLES PSY, V30, P261, DOI 10.1007/s00787-020-01511-w
   Peng P, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1138233
   Placidi GPA, 1998, NEUROPSYCHOBIOLOGY, V38, P222, DOI 10.1159/000026545
   Popkin M., 1980, Psychiatric presentations of endocrine dysfunction. Psychiatric presentations of Medical Illness, P139, DOI [10.1007/978-94-011-7677-49, DOI 10.1007/978-94-011-7677-49]
   Rana Hasanato Rana Hasanato, 2017, Epidemiology: Open Access, V7, P286, DOI 10.4172/2161-1165.1000286
   Tang R, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00340
   Toosi F., 2017, International journal of school health, V4, P1, DOI [DOI 10.5812/INTJSH.41069, 10.5812/INTJSH.41069]
   Unnikrishnan Ambika Gopalakrishnan, 2013, Indian J Endocrinol Metab, V17, P647, DOI 10.4103/2230-8210.113755
   Wagner CJ, 2019, PROG NEURO-PSYCHOPH, V92, P405, DOI 10.1016/j.pnpbp.2019.01.010
   Wolkowitz OM, 2008, Psychoneuroendocrinology: the scientific basis of clinical practice
   Xu C, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00303
   Yang L, 2021, PSYCHIAT RES, V305, DOI 10.1016/j.psychres.2021.114205
   Zhao S, 2021, ENDOCRINE, V72, P479, DOI 10.1007/s12020-020-02490-3
   Zhou LY, 2016, SCI REP-UK, V6, DOI 10.1038/srep31381
NR 46
TC 1
Z9 1
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD JAN 20
PY 2025
VL 25
IS 1
AR 54
DI 10.1186/s12888-025-06490-3
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA T0K4L
UT WOS:001402000800005
PM 39833737
OA gold
DA 2025-06-11
ER

PT J
AU Jiang, YP
   Boylan, JM
   Zilioli, S
AF Jiang, Yanping
   Boylan, Jennifer Morozink
   Zilioli, Samuele
TI Effects of the Great Recession on Educational Disparities in
   Cardiometabolic Health
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Great Recession; Metabolic syndrome; Inflammation; Psychological
   distress; Education; Socioeconomic status
ID CARDIOVASCULAR-DISEASE; SOCIOECONOMIC-STATUS; METABOLIC SYNDROME;
   AFRICAN-AMERICANS; US ADULTS; TRENDS; MORTALITY; MARKERS; RISK;
   INEQUALITIES
AB Background Macroeconomic crises can exaggerate existing educational disparities in health. Few studies, however, have examined whether macroeconomic crises get under the skin to affect educational disparities in health-related biological processes. Purpose This study aimed to examine the effect of the economic recession of 2008 (i.e., Great Recession) on educational disparities in cardiometabolic risk and self-reported psychological distress. Methods Data were drawn from two subsamples of the Midlife in the United States (MIDUS) study: the second wave of the MIDUS sample (pre-recession cohort, N = 985) and the refresher sample (post-recession cohort, N = 863). Educational attainment was categorized into high school education or less, some college, and bachelor's degree or higher. Outcomes included metabolic syndrome, C-reactive protein, and interleukin-6, as well as self-reported perceived stress, depressive symptoms, and financial distress. Results Results showed that having a bachelor's degree or higher (compared to having a high school education or less) was more strongly associated with decreased metabolic syndrome symptoms in the post-recession cohort than the pre-recession cohort, above and beyond demographic, health, and behavioral covariates. These findings did not extend to systemic inflammation or psychological distress. Conclusions Our findings suggest that chronic macroeconomic stressors may widen the educational gap in physical health, particularly cardiometabolic health, by modifying biological and anthropometric risk factors implicated in metabolic syndrome.
C1 [Jiang, Yanping; Zilioli, Samuele] Wayne State Univ, Dept Psychol, 71 W Warren Ave, Detroit, MI 48202 USA.
   [Boylan, Jennifer Morozink] Univ Colorado, Dept Hlth & Behav Sci, Denver, CO 80202 USA.
   [Zilioli, Samuele] Wayne State Univ, Dept Family Med & Publ Hlth Sci, Detroit, MI USA.
C3 Wayne State University; University of Colorado System; University of
   Colorado Denver; Wayne State University
RP Jiang, YP (corresponding author), Wayne State Univ, Dept Psychol, 71 W Warren Ave, Detroit, MI 48202 USA.
EM yanping.jiang@wayne.edu
RI Jiang, Yanping/ABC-6916-2021; Boylan, Jennifer/B-9288-2016
OI Jiang, Yanping/0000-0002-0931-9507; Zilioli, Samuele/0000-0002-1126-8913
FU National Institute on Aging at the National Institutes of Health
   [P01-AG020166]; John D. and Catherine T. MacArthur Foundation Research
   Network on Successful Midlife Development; General Clinical Research
   Centers Program of the National Center for Research Resources, National
   Institutes of Health [M01- RR023942, M01- RR00865]; Clinical and
   Translational Science Award (CTSA) program of the National Center for
   Research Resources, National Institutes of Health [1UL1RR025011]; Wayne
   State University
FX Data collection for the present study was supported by the National
   Institute on Aging at the National Institutes of Health (P01-AG020166)
   and the John D. and Catherine T. MacArthur Foundation Research Network
   on Successful Midlife Development. Support also came from the following
   grants: M01- RR023942 (Georgetown), M01- RR00865 (UCLA) from the General
   Clinical Research Centers Program, and 1UL1RR025011 (UW) from the
   Clinical and Translational Science Award (CTSA) program of the National
   Center for Research Resources, National Institutes of Health. The
   preparation of the manuscript was partly supported by a Faculty
   Competition for Postdoctoral Fellowship from Wayne State University
   (Samuele Zilioli).
CR Adler NE, 2002, HEALTH AFFAIR, V21, P60, DOI 10.1377/hlthaff.21.2.60
   ADLER NE, 1994, AM PSYCHOL, V49, P15, DOI 10.1037/0003-066X.49.1.15
   [Anonymous], 2010, MPlus Web Notes
   Bartoll X, 2015, BMC PUBLIC HEALTH, V15, DOI 10.1186/s12889-015-2204-5
   Boehm JK, 2016, J PSYCHOSOM RES, V85, P1, DOI 10.1016/j.jpsychores.2016.03.018
   Boen C, 2016, SOC SCI MED, V150, P221, DOI 10.1016/j.socscimed.2015.12.029
   Bor J, 2017, LANCET, V389, P1475, DOI 10.1016/S0140-6736(17)30571-8
   Boylan JM, 2020, HEALTH PSYCHOL, V39, P497, DOI 10.1037/hea0000866
   Bricker Jesse., 2012, Federal Reserve Bulletin, V98, P1
   Brody GH, 2013, PSYCHOL SCI, V24, P1285, DOI 10.1177/0956797612471954
   Burgard SA, 2015, ANNU REV SOCIOL, V41, P181, DOI 10.1146/annurev-soc-073014-112204
   Cagney KA, 2014, AM J PUBLIC HEALTH, V104, P498, DOI 10.2105/AJPH.2013.301566
   Carnevale Anthony P., 2016, Americas Divided Recovery: College Haves and Have-Nots, P1
   Chen E, 2016, JAMA PSYCHIAT, V73, P920, DOI 10.1001/jamapsychiatry.2016.1786
   Chetty R, 2017, SCIENCE, V356, P398, DOI 10.1126/science.aal4617
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   COHEN S, 1988, CLAR SYMP, P31
   Coibion O., Labor Markets During the COVID-19 Crisis: A Preliminary View
   Cundiff JM, 2020, CURR DIR PSYCHOL SCI, V29, P147, DOI 10.1177/0963721420901596
   Fernandes N., EC EFFECTS CORONAVIR
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Galasso V, 2020, CESIFO ECON STUD, V66, P376, DOI 10.1093/cesifo/ifaa019
   Gallo LC, 2003, PSYCHOL BULL, V129, P10, DOI 10.1037//0033-2909.129.1.10
   Glei DA, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0214947
   Glei DA, 2018, POPUL DEV REV, V44, P695, DOI 10.1111/padr.12183
   Goldman N, 2018, P NATL ACAD SCI USA, V115, P7290, DOI 10.1073/pnas.1722023115
   Hamad R, 2019, PLOS MED, V16, DOI 10.1371/journal.pmed.1002834
   Hawkley L.C., 2007, Stress and Immunity, P67, DOI DOI 10.1201/9781420003802
   Heggebo K, 2019, SCAND J PUBLIC HEALT, V47, P635, DOI 10.1177/1403494818801637
   Hout Michael., 2012, The Labor Force and the Great Recession
   Kalleberg AL, 2017, RSF-RUS SAGE J SOC S, V3, P1, DOI [10.7758/RSF.2017.3.3.01, 10.7758/rsf.2017.3.3.01]
   Kanjilal S, 2006, ARCH INTERN MED, V166, P2348, DOI 10.1001/archinte.166.21.2348
   Katikireddi SV, 2012, BMJ OPEN, V2, DOI 10.1136/bmjopen-2012-001790
   Khang YH, 2004, J EPIDEMIOL COMMUN H, V58, P308, DOI 10.1136/jech.2003.012989
   Kirsch Julie A, 2016, Health Psychol Open, V3, p2055102916652390, DOI 10.1177/2055102916652390
   Kochhar, UNEMPLOYMENT ROSE HI
   Kondo N, 2008, J EPIDEMIOL COMMUN H, V62, P869, DOI 10.1136/jech.2007.070334
   Lee WY, 2005, DIABETES RES CLIN PR, V67, P70, DOI 10.1016/j.diabres.2004.05.006
   Lewis D., US EC ACTIVITY EARLY
   Lleras-Muney A, 2005, REV ECON STUD, V72, P189, DOI 10.1111/0034-6527.00329
   Love GD, 2010, J AGING HEALTH, V22, P1059, DOI 10.1177/0898264310374355
   Lundberg S, 2016, J ECON PERSPECT, V30, P79, DOI 10.1257/jep.30.2.79
   Marmot M, 2008, LANCET, V372, P1661, DOI 10.1016/S0140-6736(08)61690-6
   Marsland AL, 2017, BRAIN BEHAV IMMUN, V64, P208, DOI 10.1016/j.bbi.2017.01.011
   MCEWEN BS, 1993, ARCH INTERN MED, V153, P2093, DOI 10.1001/archinte.153.18.2093
   Miller GE, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.117.006052
   Miller GE, 2016, HEALTH PSYCHOL, V35, P1225, DOI 10.1037/hea0000398
   Moen P, 2020, WORK AGING RETIRE, V6, P207, DOI 10.1093/workar/waaa013
   Montenovo Laura., 2020, DETERMINANTS DISPARI
   Morozink JA, 2010, HEALTH PSYCHOL, V29, P626, DOI 10.1037/a0021360
   Muscatell KA, 2020, MOL PSYCHIATR, V25, P2189, DOI 10.1038/s41380-018-0259-2
   Muthen L.K., 2012, MPLUS STAT MODELING
   Niedzwiedz CL, 2017, J EPIDEMIOL COMMUN H, V71, P1005, DOI 10.1136/jech-2017-209105
   Pearson TA, 2003, CIRCULATION, V107, P499, DOI 10.1161/01.CIR.0000052939.59093.45
   Pernenkil V, 2017, PREV MED, V102, P86, DOI 10.1016/j.ypmed.2017.07.001
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Ridker PM, 2000, NEW ENGL J MED, V342, P836, DOI 10.1056/NEJM200003233421202
   ROBERTS RE, 1983, AM J PSYCHIAT, V140, P41
   Rogers RG, 2020, J MARRIAGE FAM, V82, P1159, DOI 10.1111/jomf.12674
   Seeman T, 2018, P NATL ACAD SCI USA, V115, P3296, DOI 10.1073/pnas.1710502115
   Singh Gopal K, 2015, Int J MCH AIDS, V3, P106
   US Bureau of Labor Statistics, REC 2007 2009
   Wickham H, 2016, ggplot2: elegant graphics for data analysis, DOI [DOI 10.1007/978-3-319-24277-4, 10.1007/978-3-319-24277-4]
NR 64
TC 1
Z9 1
U1 1
U2 7
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD MAY 18
PY 2022
VL 56
IS 5
BP 428
EP 441
DI 10.1093/abm/kaab065
EA JUL 2021
PG 14
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA 1I3QZ
UT WOS:000756329000001
PM 34323265
OA Green Published
DA 2025-06-11
ER

PT J
AU Chedraui, P
   Miguel, GS
   Villacreses, D
   Dominguez, A
   Jaramillo, W
   Escobar, GS
   Pérez-López, FR
   Genazzani, AR
   Simoncini, T
AF Chedraui, Peter
   Miguel, Glenda San
   Villacreses, Diego
   Dominguez, Andrea
   Jaramillo, Winston
   Escobar, Gustavo S.
   Perez-Lopez, Faustino R.
   Genazzani, Andrea R.
   Simoncini, Tommaso
CA Res Grp Omega Women's Hlth Project
TI Assessment of insomnia and related risk factors in postmenopausal women
   screened for the metabolic syndrome
SO MATURITAS
LA English
DT Article
DE Postmenopause; Insomnia; Sleep problems; Metabolic syndrome; Athens
   insomnia scale; Hospital anxiety and depression scale
ID MENOPAUSAL TRANSITION; VASOMOTOR SYMPTOMS; SLEEP DURATION; HOT FLASHES;
   SHIFT WORK; MIDLIFE; DEPRESSION; ASSOCIATION; PREVALENCE; DISORDERS
AB Background: Sleep disturbances are common during female mid-life. Nevertheless, there is limited available information linking sleep characteristics to the menopause and the metabolic syndrome (METS).
   Objective: To assess insomnia prevalence and related risk factors in postmenopausal women screened for the METS.
   Methods: In this cross sectional study 204 natural postmenopausal women participating in a METS screening program filled out the Athens insomnia scale (AIS), the hospital anxiety and depression scale (HADS) and a general socio-demographic questionnaire. Criteria of the Adult Treatment Panel III (ATP-III) were used to define the METS.
   Results: Median age of the whole sample was 56 years. A 50.5% of women had the METS, 57.4% hot flushes, 58.3% were abdominally obese, 51.5% hypertension, 25.0% hyperglycemia, 15.7% depressed mood and 29.9% anxiety. A33.8% presented insomnia according to the AIS (scores 6 or more). The AIS displayed a high internal consistency as computed Cronbach's alpha was determined to be 0.86. Multiple linear regression analysis determined that male premature ejaculation, female psychotropic drug use, hot flush intensity, mood morbidity (higher total HADS scores) and higher parity positively and significantly correlated to higher AIS scores (more insomnia).
   Conclusion: In this postmenopausal sample insomnia was not related to the METS or its components yet to other psycho-somatic female and partner issues. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
C1 [Chedraui, Peter; Miguel, Glenda San; Villacreses, Diego; Dominguez, Andrea; Jaramillo, Winston; Escobar, Gustavo S.] Univ Catolica Santiago Guayaquil, Fac Ciencias Med, Inst Biomed, Guayaquil, Ecuador.
   [Perez-Lopez, Faustino R.] Univ Zaragoza, Lozano Blesa Univ Hosp, Fac Med, Dept Obstet & Gynecol, E-50009 Zaragoza, Spain.
   [Genazzani, Andrea R.; Simoncini, Tommaso] Univ Pisa, Div Obstet & Gynecol, Dept Reprod Med & Child Dev, Mol & Cellular Gynecol Endocrinol Lab, I-56100 Pisa, Italy.
C3 Lozano Blesa University Clinical Hospital; University of Zaragoza;
   University of Pisa
RP Chedraui, P (corresponding author), Univ Catolica Santiago Guayaquil, Fac Ciencias Med, Inst Biomed, POB 09-01-4671, Guayaquil, Ecuador.
EM peter.chedraui@cu.ucsg.edu.ec
RI Simoncini, Tommaso/AAC-1879-2019; Blümel, Juan Enrique/JUV-6950-2023
OI Simoncini, Tommaso/0000-0002-2971-0079; Perez-Lopez, Faustino
   R./0000-0002-2801-416X; Escobar Valdivieso, Gustavo
   Saul/0000-0003-1690-3936; Jaramillo, Winston/0000-0001-7547-214X
FU Universidad Catolica de Santiago de Guayaquil, Ecuador [SIU-3373-2011]
FX This research has been supported by the Universidad Catolica de Santiago
   de Guayaquil, Ecuador, through grant No. SIU-3373-2011 (The Omega
   Women's Health Project 2011) provided by the Sistema de Investigacion y
   Desarrollo.
CR [Anonymous], 2012, Obesity and overweight
   [Anonymous], MENOPAUSE
   Arakane M, 2011, MATURITAS, V69, P157, DOI 10.1016/j.maturitas.2011.02.015
   Berecki-Gisolf J, 2009, MENOPAUSE, V16, P1021, DOI 10.1097/gme.0b013e3181a8c49f
   Blümel JE, 2012, MATURITAS, V72, P359, DOI 10.1016/j.maturitas.2012.05.011
   Blümel JE, 2012, MENOPAUSE, V19, P433, DOI 10.1097/gme.0b013e318231fc79
   Blümel JE, 2011, MENOPAUSE, V18, P778, DOI 10.1097/gme.0b013e318207851d
   Blumel JE, CLIMACTERIC IN PRESS
   Castelo-Branco C, 2003, MATURITAS, V45, P205, DOI 10.1016/S0378-5122(03)00140-3
   Chedraui P, 2009, CLIMACTERIC, V12, P395, DOI 10.1080/13697130902718150
   Chedraui P, 2009, CLIMACTERIC, V12, P213, DOI 10.1080/13697130802607727
   Chedraui P, 2010, MATURITAS, V65, P378, DOI 10.1016/j.maturitas.2009.11.024
   Chedraui P, 2010, MATURITAS, V65, P75, DOI 10.1016/j.maturitas.2009.11.003
   Chervin RD, 2000, CHEST, V118, P372, DOI 10.1378/chest.118.2.372
   Choi JK, 2011, TOHOKU J EXP MED, V225, P187, DOI 10.1620/tjem.225.187
   Cuadros JL, 2012, MATURITAS, V72, P367, DOI 10.1016/j.maturitas.2012.05.012
   Fernandez-Alonso Ana M, 2010, Menopause Int, V16, P105, DOI 10.1258/mi.2010.010029
   Freeman EW, 2010, MENOPAUSE, V17, P823, DOI 10.1097/gme.0b013e3181db9f8b
   Frost P, 2009, SCAND J WORK ENV HEA, V35, P163, DOI 10.5271/sjweh.1319
   Ghiasvand M., 2006, LIPIDS HLTH DIS, V10, P5
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Hall MH, 2008, SLEEP, V31, P635, DOI 10.1093/sleep/31.5.635
   Hidalgo LA, 2006, GYNECOL ENDOCRINOL, V22, P447, DOI 10.1080/09513590600890272
   Jansson-Fröjmark M, 2008, J PSYCHOSOM RES, V64, P443, DOI 10.1016/j.jpsychores.2007.10.016
   Joffe H, 2009, MENOPAUSE, V16, P671, DOI 10.1097/gme.0b013e3181957377
   Kravitz HM, 2003, MENOPAUSE, V10, P19, DOI 10.1097/01.GME.0000030707.35686.5A
   Lee SW, 2012, ARCH GYNECOL OBSTET, V285, P541, DOI 10.1007/s00404-011-2016-5
   Llaneza P, 2012, MATURITAS, V71, P120, DOI 10.1016/j.maturitas.2011.11.017
   Morikawa Y, 2005, SCAND J WORK ENV HEA, V31, P179, DOI 10.5271/sjweh.867
   Morin CM, 2011, CAN J PSYCHIAT, V56, P540, DOI 10.1177/070674371105600905
   Nenclares Portocarrero Alejandro, 2005, Salud Ment, V28, P34
   Ohayon MM, 2006, ARCH INTERN MED, V166, P1262, DOI 10.1001/archinte.166.12.1262
   Pérez-López FR, 2009, FERTIL STERIL, V92, P1171, DOI 10.1016/j.fertnstert.2009.06.032
   Rosa RR, 2000, PSYCHOSOM MED, V62, P474, DOI 10.1097/00006842-200007000-00004
   Royer M, 2007, CLIMACTERIC, V10, P164, DOI 10.1080/13697130701258895
   Savard J, 2004, J PAIN SYMPTOM MANAG, V27, P513, DOI 10.1016/j.jpainsymman.2003.10.013
   Soldatos CR, 2000, J PSYCHOSOM RES, V48, P555, DOI 10.1016/S0022-3999(00)00095-7
   Spiegel K, 2005, J APPL PHYSIOL, V99, P2008, DOI 10.1152/japplphysiol.00660.2005
   Tan HM, 2012, J SEX MED, V9, P663, DOI 10.1111/j.1743-6109.2011.02582.x
   Thurston RC, 2012, MENOPAUSE, V19, P742, DOI 10.1097/gme.0b013e3182422973
   Wolk R, 2005, CURR PROB CARDIOLOGY, V30, P625, DOI 10.1016/j.cpcardiol.2005.07.002
   Young T, 2003, SLEEP, V26, P667, DOI 10.1093/sleep/26.6.667
   Zervas IM, 2009, MENOPAUSE, V16, P837, DOI 10.1097/gme.0b013e318196063e
   Zhang B, 2006, SLEEP, V29, P85, DOI 10.1093/sleep/29.1.85
   Zhang Lin, 2007, Neurosci Bull, V23, P236, DOI 10.1007/s12264-007-0035-9
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 46
TC 23
Z9 24
U1 0
U2 19
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD FEB
PY 2013
VL 74
IS 2
BP 154
EP 159
DI 10.1016/j.maturitas.2012.10.017
PG 6
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA 083DY
UT WOS:000314444100009
PM 23176759
DA 2025-06-11
ER

PT J
AU Caceres, BA
   Wardecker, BM
   Anderson, J
   Hughes, TL
AF Caceres, Billy A.
   Wardecker, Britney M.
   Anderson, Jocelyn
   Hughes, Tonda L.
TI Revictimization Is Associated With Higher Cardiometabolic Risk in Sexual
   Minority Women
SO WOMENS HEALTH ISSUES
LA English
DT Article
ID ADVERSE CHILDHOOD EXPERIENCES; INTIMATE PARTNER VIOLENCE; MENTAL-HEALTH;
   CARDIOVASCULAR-DISEASE; MULTIDIMENSIONAL SCALE; COMMUNITY SAMPLE;
   NATIONAL SAMPLE; PHYSICAL ABUSE; NURSES HEALTH; VICTIMIZATION
AB Objectives: Although there is evidence that interpersonal trauma is associated with cardiometabolic risk in women, previous studies have not assessed the potential role of revictimization (victimization in both childhood and adulthood) among sexual minority women. Methods: We used data from the Chicago Health and Life Experiences of Women study to examine the associations of revictimization (including physical, sexual, and any revictimization) with self-reported psychosocial factors, health behaviors, and cardiometabolic risk factors (e.g., obesity, hypertension, and diabetes). We tested multiple logistic regression models, adjusted for covariates, to estimate odds ratios of the associations between revictimization and cardiometabolic risk. Results: The sample included 615 sexual minority women with a mean age of 40.0 years; 38.7% White. Eighty-three (13.5%) and 101 (16.4%) participants reported experiencing sexual revictimization and physical revictimization, respectively. Each form of revictimization was associated with higher odds of reporting lifetime depression and recent binge eating, but lower odds of having high social support. Physical revictimization was associated with higher odds of obesity (adjusted odds ratio [AOR], 2.38; 95% confidence interval [CI], 1.38-4.10) and hypertension (AOR, 3.31; 95% CI, 1.70-6.46). Similarly, participants who reported any revictimization were more likely to have obesity (AOR, 2.36; 95% CI, 1.42-3.92) and hypertension (AOR, 2.60; 95% CI, 1.31-5.26). No form of revictimization was associated with a higher odds of diabetes. Conclusions: The higher odds of obesity and hypertension observed among sexual minority women who reported revictimization reinforce the need for early interventions to reduce cardiometabolic risk in this vulnerable population. (c) 2021 Jacobs Institute of Women's Health. Published by Elsevier Inc.
C1 [Caceres, Billy A.; Hughes, Tonda L.] Columbia Univ, Program Study LGBT Hlth, Sch Nursing, 617 West 168th St,Room 239, New York, NY 10032 USA.
   [Wardecker, Britney M.; Anderson, Jocelyn] Penn State Coll Nursing, University Pk, PA USA.
C3 Columbia University; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); Pennsylvania State University; Pennsylvania State
   University - University Park; Penn State Health
RP Caceres, BA (corresponding author), Columbia Univ, Program Study LGBT Hlth, Sch Nursing, 617 West 168th St,Room 239, New York, NY 10032 USA.
EM bac2134@cumc.columbia.edu
RI Anderson, Jocelyn/NIU-1427-2025
OI Anderson, Jocelyn/0000-0003-0572-8378
FU National Institute on Alcohol Abuse and Alcoholism, United States
   [R01AA013328, K23AA027288]; National Heart, Lung, and Blood Institute,
   United States [K01HL146965]
FX Supported by the National Institute on Alcohol Abuse and Alcoholism,
   United States under award numbers R01AA013328 to Dr. Hughes and
   K23AA027288 to Dr. Anderson. Dr. Caceres was supported by an award from
   the National Heart, Lung, and Blood Institute, United States
   (K01HL146965).
CR Aakvaag HF, 2019, PSYCHOL TRAUMA-US, V11, P43, DOI 10.1037/tra0000373
   Aaron DJ, 2007, OBESITY, V15, P1023, DOI 10.1038/oby.2007.634
   American College of Obstetricians and Gynecologists, 2012, COMM HLTH CAR VULN W
   American Psychiatric Association, 2000, spectrum disorders using the current DSM-IV-TR diagnostic, V4th, DOI 10.1176/dsm10.1176/appi.books.9780890420249.dsm-iv-tr
   Andersen JP, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054691
   [Anonymous], 2020, Defining Adult Overweight and Obesity
   Austin SB, 2008, J WOMENS HEALTH, V17, P597, DOI 10.1089/jwh.2007.0450
   Balsam KF, 2005, J CONSULT CLIN PSYCH, V73, P477, DOI 10.1037/0022-006X.73.3.477
   Balsam KF, 2011, J INTERPERS VIOLENCE, V26, P1798, DOI 10.1177/0886260510372946
   Bankoff SM, 2014, EAT DISORD, V22, P261, DOI 10.1080/10640266.2014.890458
   Berens AE, 2017, BMC MED, V15, DOI 10.1186/s12916-017-0895-4
   Blosnich J, 2013, TOB CONTROL, V22, P66, DOI 10.1136/tobaccocontrol-2011-050181
   Bostwick WB, 2010, AM J PUBLIC HEALTH, V100, P468, DOI 10.2105/AJPH.2008.152942
   Caceres BA, 2020, CIRCULATION, V142, pE321, DOI 10.1161/CIR.0000000000000914
   Caceres BA, 2022, ETHNIC HEALTH, V27, P617, DOI 10.1080/13557858.2020.1740174
   Caceres BA, 2019, J WOMENS HEALTH, V28, P1200, DOI 10.1089/jwh.2018.7381
   Caceres BA, 2019, J CARDIOVASC NURS, V34, P380, DOI 10.1097/JCN.0000000000000588
   Caceres BA, 2019, AM J HEALTH PROMOT, V33, P576, DOI 10.1177/0890117118810246
   Caceres BA, 2018, WOMEN HEALTH ISS, V28, P333, DOI 10.1016/j.whi.2018.03.004
   Caceres BA, 2017, AM J PUBLIC HEALTH, V107, pE13, DOI 10.2105/AJPH.2016.303630
   Caceres BA, 2016, J CLIN NURS, V25, P3728, DOI 10.1111/jocn.13415
   Calzo JP, 2017, CURR PSYCHIAT REP, V19, DOI 10.1007/s11920-017-0801-y
   Canan SN, 2021, J INTERPERS VIOLENCE, V36, P9100, DOI 10.1177/0886260519863725
   Corliss HL, 2018, DIABETES CARE, V41, P1448, DOI 10.2337/dc17-2656
   Curry SJ, 2018, JAMA-J AM MED ASSOC, V320, P1678, DOI 10.1001/jama.2018.14741
   Czaja SJ, 2016, AGING MENT HEALTH, V20, P1107, DOI 10.1080/13607863.2015.1072795
   Danese A, 2009, ARCH PEDIAT ADOL MED, V163, P1135, DOI 10.1001/archpediatrics.2009.214
   DeCou CR, 2021, J INTERPERS VIOLENCE, V36, P314, DOI 10.1177/0886260517727492
   Edmondson D, 2017, LANCET PSYCHIAT, V4, P320, DOI 10.1016/S2215-0366(16)30377-7
   Eliason MJ, 2015, WOMEN HEALTH ISS, V25, P162, DOI 10.1016/j.whi.2014.12.001
   Felitti VJ, 1998, AM J PREV MED, V14, P245, DOI 10.1016/S0749-3797(98)00017-8
   Finkelhor D, 2007, DEV PSYCHOPATHOL, V19, P149, DOI 10.1017/S0954579407070083
   Friedman EM, 2015, J AGING HEALTH, V27, P1311, DOI 10.1177/0898264315580122
   Friedman MS, 2011, AM J PUBLIC HEALTH, V101, P1481, DOI 10.2105/AJPH.2009.190009
   Hatzenbuehler ML, 2014, HEALTH PSYCHOL, V33, P1185, DOI 10.1037/hea0000126
   Hawn SE, 2018, J AM COLL HEALTH, V66, P467, DOI 10.1080/07448481.2018.1431911
   Hequembourg AL, 2013, VIOLENCE AGAINST WOM, V19, P634, DOI 10.1177/1077801213490557
   Hopper EK., 2009, OPEN HLTH SERVICES P, V2, P131, DOI [DOI 10.2174/1874924001003020080, DOI 10.2174/1874924001003010080, 10.2174/1874924001003010080]
   Hudson JI, 2010, AM J CLIN NUTR, V91, P1568, DOI 10.3945/ajcn.2010.29203
   Hughes T, 2010, ADDICTION, V105, P2130, DOI 10.1111/j.1360-0443.2010.03088.x
   Hughes T, 2010, SOC SCI MED, V71, P824, DOI 10.1016/j.socscimed.2010.05.009
   Hughes TL, 2006, J STUD ALCOHOL, V67, P579, DOI 10.15288/jsa.2006.67.579
   Hughes TL, 2010, ADDICT BEHAV, V35, P1152, DOI 10.1016/j.addbeh.2010.07.004
   Katz-Wise SL, 2014, J OBES, V2014, DOI 10.1155/2014/537242
   Katz-Wise SL, 2012, J SEX RES, V49, P142, DOI 10.1080/00224499.2011.637247
   Kinsky S, 2016, J WOMENS HEALTH, V25, P784, DOI 10.1089/jwh.2015.5496
   Laska MN, 2015, AM J PUBLIC HEALTH, V105, P111, DOI 10.2105/AJPH.2014.302094
   Lee SY, 2020, J BEHAV MED, V43, P131, DOI 10.1007/s10865-019-00067-8
   Lick DJ, 2013, PERSPECT PSYCHOL SCI, V8, P521, DOI 10.1177/1745691613497965
   Liu H, 2019, LGBT HEALTH, V6, P227, DOI 10.1089/lgbt.2018.0153
   Lopez G., 2018, J INTERPERS VIOLENCE
   Mason SM, 2013, DIABETES CARE, V36, P1159, DOI 10.2337/dc12-1082
   Mason SM, 2012, ANN EPIDEMIOL, V22, P562, DOI 10.1016/j.annepidem.2012.05.003
   Mattocks KM, 2013, J GEN INTERN MED, V28, pS604, DOI 10.1007/s11606-013-2357-9
   McCabe SE, 2018, AM J PREV MED, V54, P736, DOI 10.1016/j.amepre.2018.03.009
   Miller GE, 2011, PSYCHOL BULL, V137, P959, DOI 10.1037/a0024768
   Miron LR, 2014, CHILD ABUSE NEGLECT, V38, P1848, DOI 10.1016/j.chiabu.2014.10.004
   Molina Y, 2014, LGBT HEALTH, V1, P131, DOI 10.1089/lgbt.2013.0007
   Morris Jessica F, 2003, J Lesbian Stud, V7, P67, DOI 10.1300/J155v07n04_05
   Mosack KE, 2010, J CHILD SEX ABUS, V19, P43, DOI 10.1080/10538710903485591
   Nagata JM, 2018, INT J EAT DISORDER, V51, P931, DOI 10.1002/eat.22927
   Najdowski CJ, 2011, J TRAUMA STRESS, V24, P218, DOI 10.1002/jts.20610
   Nieto-Martínez R, 2017, CURR DIABETES REP, V17, DOI 10.1007/s11892-017-0949-1
   Okunrintemi V, 2020, CIRCULATION, V142
   Olguin P, 2017, EAT WEIGHT DISORD-ST, V22, P13, DOI 10.1007/s40519-016-0313-5
   Palmisano GL, 2016, J BEHAV ADDICT, V5, P11, DOI 10.1556/2006.5.2016.018
   Pittenger SL, 2018, CHILD MALTREATMENT, V23, P137, DOI 10.1177/1077559517733813
   Plöderl M, 2015, INT REV PSYCHIATR, V27, P367, DOI 10.3109/09540261.2015.1083949
   Qureshi RI, 2018, J HOMOSEXUAL, V65, P167, DOI 10.1080/00918369.2017.1311555
   Rich-Edwards JW, 2010, AM J PREV MED, V39, P529, DOI 10.1016/j.amepre.2010.09.007
   Riley EH, 2010, J EPIDEMIOL COMMUN H, V64, P413, DOI 10.1136/jech.2009.095109
   Santana DD, 2019, J EAT DISORD, V7, DOI 10.1186/s40337-019-0266-y
   Scoglio AAJ, 2021, TRAUMA VIOLENCE ABUS, V22, P41, DOI 10.1177/1524838018823274
   Smith HA, 2010, J WOMENS HEALTH, V19, P1525, DOI 10.1089/jwh.2009.1763
   Stein DJ, 2010, ANN CLIN PSYCHIATRY, V22, P19
   Stoddard J, 2009, J HOMOSEXUAL, V56, P407, DOI 10.1080/00918360902821395
   Stroem IF, 2019, VIOLENCE AGAINST WOM, V25, P1696, DOI 10.1177/1077801218818381
   Su SY, 2015, CIRCULATION, V131, P1674, DOI 10.1161/CIRCULATIONAHA.114.013104
   Substance Abuse and Mental Health Services Administration Center for Substance Abuse Treatment, 2014, TREATMENT IMPROVEMEN
   Suglia SF, 2018, CIRCULATION, V137, pE15, DOI 10.1161/CIR.0000000000000536
   Suglia SF, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-1149
   Szalacha LA, 2017, BMC WOMENS HEALTH, V17, DOI 10.1186/s12905-017-0452-5
   Ullman SE, 2016, ADDICT BEHAV, V53, P7, DOI 10.1016/j.addbeh.2015.09.010
   Valenstein-Mah H, 2015, J TRAUMA STRESS, V28, P484, DOI 10.1002/jts.22042
   Walker HE, 2019, TRAUMA VIOLENCE ABUS, V20, P67, DOI 10.1177/1524838017692364
   WHO, 2013, WHO TECH REP SER, V984, P1
   Wilson MA, 2019, STRESS, V22, P530, DOI 10.1080/10253890.2019.1621283
   ZIMET GD, 1990, J PERS ASSESS, V55, P610, DOI 10.1207/s15327752jpa5503&4_17
   ZIMET GD, 1988, J PERS ASSESS, V52, P30, DOI 10.1207/s15327752jpa5201_2
NR 89
TC 8
Z9 10
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1049-3867
EI 1878-4321
J9 WOMEN HEALTH ISS
JI Womens Health Iss.
PD JUL-AUG
PY 2021
VL 31
IS 4
BP 341
EP 352
DI 10.1016/j.whi.2021.02.004
EA JUN 2021
PG 12
WC Public, Environmental & Occupational Health; Women's Studies
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Women's Studies
GA TG7AH
UT WOS:000671552500008
PM 33766475
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Aung, TT
   Wah, W
   Chakraborti, A
   Garg, V
AF Aung, The The
   Wah, Win
   Chakraborti, Arnob
   Garg, Vikas
TI Subclinical hypothyroidism and metabolic syndrome in psychiatric
   patients: A systematic literature review and meta-analysis
SO AUSTRALASIAN PSYCHIATRY
LA English
DT Review
DE subclinical hypothyroidism; metabolic syndrome; psychiatric disorders;
   systematic review; meta-analysis
ID BIPOLAR DISORDER; THYROID-DYSFUNCTION; RISK; DEPRESSION; COMPONENTS;
   HORMONE
AB ObjectiveThe systematic review evaluated the association of subclinical hypothyroidism (SCH) with metabolic syndrome (MetS) and specific MetS components in people with major psychiatric disorders.MethodsA systematic review and meta-analysis was conducted to evaluate the association of SCH with MetS and its components in people with major psychiatric conditions.ResultsFive studies incorporating 24,158 participants met the inclusion criteria. All five studies comprised patients with depression and/or anxiety. Three studies incorporating 3365 participants were suitable for the meta-analysis. The pooled Odds Ratio (OR) of MetS was 3.46 (95% Confidence Interval/CI = 1.39-8.62) in major depressive disorder (MDD) and anxiety disorders patients with concurrent SCH compared to those without SCH. Meta-analysis showed a significant positive association between SCH and high body mass index (OR = 2.58, 95%CI = 1.33-5.01), high fasting plasma glucose (OR = 3.05, 95%CI = 1.79-5.18) and low high-density lipoprotein cholesterol (OR = 2.30, 95%CI = 1.82-2.92).ConclusionsThese findings suggest a significant positive association between MetS and SCH in people with MDD and anxiety disorders. This review informed the clinical implications of MetS in MDD with comorbid SCH and the importance of early diagnosis and treatment for SCH and MetS in psychiatric patients.
C1 [Aung, The The] Launceston Gen Hosp, Launceston, Tas, Australia.
   [Wah, Win] Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia.
   [Chakraborti, Arnob] Royal Hobart Hosp, Tasmanian Mental Hlth Serv, Hobart, Tas, Australia.
   [Garg, Vikas] Darling Downs Hosp & Hlth Serv, Acute Mental Hlth Unit, Toowoomba, Qld, Australia.
   [Garg, Vikas] Univ Queensland, Rural Clin Sch, Toowoomba, Qld, Australia.
   [Garg, Vikas] Griffith Univ, Sch Med & Dent, Gold Coast Campus, Southport, Qld, Australia.
C3 Launceston General Hospital; Monash University; Royal Hobart Hospital;
   University of Queensland; Griffith University; Griffith University -
   Gold Coast Campus
RP Aung, TT (corresponding author), Launceston Gen Hosp, Tasmanian Mental Hlth Serv, Launceston, Tas 7250, Australia.
RI ; Garg, Vikas/E-8263-2016
OI Wah, Win/0000-0002-4242-5651; Garg, Vikas/0000-0001-6886-3003
FU Project of the RANZCP (Royal Australian and New Zealand College of
   Psychiatrists) Fellowship Program
FX This research project was conducted as the scholarly project of the
   RANZCP (Royal Australian and New Zealand College of Psychiatrists)
   Fellowship Program
CR Badillo N, 2022, CUREUS J MED SCIENCE, V14, DOI 10.7759/cureus.21841
   Bauer M, 2014, BIPOLAR DISORD, V16, P58, DOI 10.1111/bdi.12150
   Berlin I, 1999, INT J NEUROPSYCHOP, V2, P105, DOI 10.1017/S146114579900139X
   Biondi B, 2019, JAMA-J AM MED ASSOC, V322, P153, DOI 10.1001/jama.2019.9052
   Cooper DS, 2012, LANCET, V379, P1142, DOI 10.1016/S0140-6736(11)60276-6
   Demartini B, 2010, PANMINERVA MED, V52, P277
   Ding X., 2021, Endocr J, pEJ20
   Fazio S, 2004, RECENT PROG HORM RES, V59, P31, DOI 10.1210/rp.59.1.31
   GEWIRTZ GR, 1988, AM J PSYCHIAT, V145, P1012
   Gyawali P, 2015, DIABETES METAB J, V39, P66, DOI 10.4093/dmj.2015.39.1.66
   HAGGERTY JJ, 1993, AM J PSYCHIAT, V150, P508
   Kang CY, 2023, EUR ARCH PSY CLIN N, V273, P183, DOI 10.1007/s00406-022-01415-7
   Kim MD, 2020, J AFFECT DISORDERS, V264, P494, DOI 10.1016/j.jad.2019.11.080
   Lambert CG, 2016, BIPOLAR DISORD, V18, P247, DOI 10.1111/bdi.12391
   Li RX, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-64975-5
   Loh HH, 2019, BMC PSYCHIATRY, V19, DOI 10.1186/s12888-018-2006-2
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Pearce EN, 2012, J CLIN ENDOCR METAB, V97, P326, DOI 10.1210/jc.2011-2532
   Pearce SHS, 2013, EUR THYROID J, V2, P215, DOI 10.1159/000356507
   Peng P, 2024, EUR ARCH PSY CLIN N, V274, P573, DOI 10.1007/s00406-023-01588-9
   Penninx BWJH, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-129
   Rastgooye Haghi Alireza, 2017, Iran J Pathol, V12, P106
   Sami A, 2018, PAK J MED SCI, V34, P980, DOI 10.12669/pjms.344.14127
   Shelton RC, 2010, PROG NEUROBIOL, V91, P275, DOI 10.1016/j.pneurobio.2010.04.004
   Sublette ME, 2012, PSYCHOSOM MED, V74, P668, DOI 10.1097/PSY.0b013e318268de9f
   van Rossum EFC, 2002, DIABETES, V51, P3128, DOI 10.2337/diabetes.51.10.3128
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   VANDERPUMP MPJ, 1995, CLIN ENDOCRINOL, V43, P55, DOI 10.1111/j.1365-2265.1995.tb01894.x
   Wu ZY, 2022, J CLIN ENDOCR METAB, V107, pE2365, DOI 10.1210/clinem/dgac110
   Zhao S, 2021, ENDOCRINE, V72, P479, DOI 10.1007/s12020-020-02490-3
NR 30
TC 1
Z9 1
U1 0
U2 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1039-8562
EI 1440-1665
J9 AUSTRALAS PSYCHIATRY
JI Australas. Psychiatry
PD OCT
PY 2024
VL 32
IS 5
BP 470
EP 476
DI 10.1177/10398562241267149
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA M0F6Y
UT WOS:001354393500004
PM 39046130
DA 2025-06-11
ER

PT J
AU Goldbacher, EM
   Bromberger, J
   Matthews, KA
AF Goldbacher, Edie M.
   Bromberger, Joyce
   Matthews, Karen A.
TI Lifetime History of Major Depression Predicts the Development of the
   Metabolic Syndrome in Middle-Aged Women
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE metabolic syndrome; depression; women; menopause; alcohol
ID PHYSICAL-ACTIVITY; DRINKING PATTERN; NATIONAL-HEART; HEALTHY WOMEN;
   YOUNG-ADULTS; RISK-FACTOR; PREVALENCE; DISEASE; ASSOCIATION; SYMPTOMS
AB Objective: To prospectively examine the association of major depression with incidence of the metabolic syndrome in women. Methods: Data were drawn from one of seven sites of the Study of Women's Health Across the Nation (SWAN), a prospective cohort study of the menopausal transition. Participants were 429 (34.5% African-American) women. Major depression and comorbid diagnoses were assessed via the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition Axis I Disorders at baseline and seven annual follow-up evaluations. The metabolic syndrome was measured at baseline and each follow-up evaluation (except the second) based on National Cholesterol Education Program (NCEP) criteria. Results: Longitudinal generalized estimating equations (GEE) models indicated that, in women who were free of the metabolic syndrome at baseline, a lifetime major depression history or current major depressive episode at baseline was significantly associated with the onset and presence of the metabolic syndrome during the follow-up (odds ratio=1.82; 95% Confidence Interval (CI)=1.06-3.14). Survival analyses showed that, in women who were free of the metabolic syndrome at baseline, a lifetime major depression history or current major depressive episode at baseline predicted increased risk of developing the metabolic syndrome during the follow-up (hazard ratio=1.66; 95% CI=0.99-3.75). Lifetime history of alcohol abuse or dependence predicted incident metabolic syndrome and attenuated the association between depression and the metabolic syndrome in both models. Conclusions: This study documents that major depression is a significant predictor of the onset of the metabolic syndrome. Intervention studies targeting depression may prevent the development of the metabolic syndrome in women.
C1 [Goldbacher, Edie M.] Temple Univ, Ctr Obes Res & Educ, Philadelphia, PA 19140 USA.
   [Bromberger, Joyce; Matthews, Karen A.] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA.
   [Matthews, Karen A.] Univ Pittsburgh, Dept Psychiat & Psychol, Pittsburgh, PA 15261 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple
   University; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh
RP Goldbacher, EM (corresponding author), Temple Univ, Ctr Obes Res & Educ, 3223 N Broad St,Suite 175, Philadelphia, PA 19140 USA.
EM ediemg@temple.edu
RI Stefanadis, Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454; bromberger,
   joyce/0000-0001-7101-3800
FU National Institutes of Health (NIH); Department of Health and Human
   Services (DHHS); National Institute on Aging (NIA); National Institute
   of Nursing Research (NINR); NIH Office of Research on Women's Health
   (ORWH) [NR004061, AG012505, AG012535, AG012531, AG012539, AG012546,
   AG012553, AG012554, AG012495]
FX The Study of Women's Health Across the Nation (SWAN) has grant support
   from the National Institutes of Health (NIH), Department of Health and
   Human Services (DHHS), through the National Institute on Aging (NIA),
   the National Institute of Nursing Research (NINR) and the NIH Office of
   Research on Women's Health (ORWH) (Grants NR004061, AG012505, AG012535,
   AG012531, AG012539, AG012546, AG012553, AG012554, and AG012495). The
   content of this paper is solely the responsibility of the authors and
   does not necessarily represent the official views of the NIA, NINR,
   ORWH, or the NIH.
CR Allison PD., 2010, SURVIVAL ANAL USING
   [Anonymous], 2000, Diagnostic and statistical manual of mental disorders, V4th
   Athyros VG, 2007, ANGIOLOGY, V58, P689, DOI 10.1177/0003319707306146
   BAECKE JAH, 1982, AM J CLIN NUTR, V36, P936
   BLOCK G, 1992, J AM DIET ASSOC, V92, P686
   Boyer P, 2000, ACTA PSYCHIAT SCAND, V102, P24, DOI 10.1111/j.0065-1591.2000.acp29[dash]04.x
   Breslau N, 1998, ARCH GEN PSYCHIAT, V55, P161, DOI 10.1001/archpsyc.55.2.161
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   CAMACHO TC, 1991, AM J EPIDEMIOL, V134, P220, DOI 10.1093/oxfordjournals.aje.a116074
   Cigolini M, 1996, INT J OBESITY, V20, P206
   Dorn JM, 2003, J NUTR, V133, P2655, DOI 10.1093/jn/133.8.2655
   Fan AZ, 2006, EUR J EPIDEMIOL, V21, P129, DOI 10.1007/s10654-005-5457-y
   Ford ES, 2005, OBES RES, V13, P608, DOI 10.1038/oby.2005.65
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   Ford ES, 2005, DIABETES CARE, V28, P2745, DOI 10.2337/diacare.28.11.2745
   Goldbacher EM, 2007, ANN BEHAV MED, V34, P240, DOI 10.1007/BF02874549
   Grundy SM, 2006, DIABETES CARE, V29, P1689, DOI 10.2337/dc05-2307
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Heiskanen TH, 2006, J CLIN PSYCHIAT, V67, P1422, DOI 10.4088/JCP.v67n0913
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Huang MH, 2002, MENOPAUSE, V9, P309, DOI 10.1097/00042192-200209000-00003
   Jennings JR, 2007, SLEEP, V30, P219, DOI 10.1093/sleep/30.2.219
   Kahn R, 2006, DIABETES CARE, V29, P1693, DOI 10.2337/dc06-0671
   KESSLER RC, 1993, J AFFECT DISORDERS, V29, P85, DOI 10.1016/0165-0327(93)90026-G
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Knol MJ, 2006, DIABETOLOGIA, V49, P837, DOI 10.1007/s00125-006-0159-x
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178, DOI 10.4088/JCP.v69n0202
   Lett HS, 2004, PSYCHOSOM MED, V66, P305, DOI 10.1097/01.psy.0000126207.43307.c0
   LIANG KY, 1986, BIOMETRIKA, V73, P13, DOI 10.1093/biomet/73.1.13
   McCaffery JM, 2003, PSYCHOSOM MED, V65, P490, DOI 10.1097/01.PSY.0000041545.52924.82
   Muldoon MF, 2006, J CLIN ENDOCR METAB, V91, P718, DOI 10.1210/jc.2005-1654
   Musselman DL, 2003, BIOL PSYCHIAT, V54, P317, DOI 10.1016/S0006-3223(03)00569-9
   MYERS GL, 1989, CLIN LAB MED, V9, P105, DOI 10.1016/S0272-2712(18)30645-0
   Panagiotakos DB, 2007, J AM DIET ASSOC, V107, P979, DOI 10.1016/j.jada.2007.03.006
   Parker L, 2003, DIABETIC MED, V20, P406, DOI 10.1046/j.1464-5491.2003.00949.x
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Räikkönen K, 2007, DIABETES CARE, V30, P872, DOI 10.2337/dc06-1857
   Roriz-Cruz M, 2007, J AM GERIATR SOC, V55, P374, DOI 10.1111/j.1532-5415.2007.01068.x
   Rosal MC, 2001, PREV MED, V33, P586, DOI 10.1006/pmed.2001.0929
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Sowers M., 2000, MENOPAUSE BIOL PATHO
   SPITZER RL, 1992, ARCH GEN PSYCHIAT, V49, P624
   STEINER PM, 1981, J CLIN CHEM CLIN BIO, V19, P850
   Thayer JF, 2006, INT J PSYCHOPHYSIOL, V59, P244, DOI 10.1016/j.ijpsycho.2005.10.013
   Tsuno N, 2005, J CLIN PSYCHIAT, V66, P1254, DOI 10.4088/JCP.v66n1008
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
   Vogelzangs N, 2007, PSYCHONEUROENDOCRINO, V32, P151, DOI 10.1016/j.psyneuen.2006.11.009
   Wannamethee SG, 2005, INT J OBESITY, V29, P1436, DOI 10.1038/sj.ijo.0803034
   WARNICK GR, 1978, J LIPID RES, V19, P65
   Yokoyama H, 2007, INTERNAL MED, V46, P1345, DOI 10.2169/internalmedicine.46.6196
NR 51
TC 123
Z9 134
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD APR
PY 2009
VL 71
IS 3
BP 266
EP 272
DI 10.1097/PSY.0b013e318197a4d5
PG 7
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 434NQ
UT WOS:000265281800003
PM 19188528
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Teasdale, SB
   Burrows, TL
   Hayes, T
   Hsia, CY
   Watkins, A
   Curtis, J
   Ward, PB
AF Teasdale, Scott B.
   Burrows, Tracy L.
   Hayes, Tegan
   Hsia, Cin Y.
   Watkins, Andrew
   Curtis, Jackie
   Ward, Philip B.
TI Dietary intake, food addiction and nutrition knowledge in young people
   with mental illness
SO NUTRITION & DIETETICS
LA English
DT Article
DE depression; diet; food addiction; mental illness; nutrition; psychosis
ID FREQUENCY QUESTIONNAIRE; PSYCHOTIC DISORDERS; METABOLIC SYNDROME;
   VALIDATION; SCHIZOPHRENIA; INTERVENTIONS; VALIDITY; VERSION; HEALTH;
   RISK
AB Aim The aim of this study was to comprehensively assess dietary intake, nutrition knowledge and food addiction in young people with mental illness.
   Methods This was a three-arm cross-sectional study of 16-25-year-olds attending community mental health services who met criteria for: (i) first-episode psychosis (FEP), (ii) ultra-high risk for psychosis (UHR) or (iii) depression/anxiety. Participants self-completed three validated questionnaires: (i) Australian Eating Survey, (ii) General Nutrition Knowledge Questionnaire-Revised and (iii) Yale Food Addiction Score Questionnaire.
   Results Thirty participants (mean age 19.7 +/- 2.5 years) completed the study (10 per study arm); 43% of the energy intake was obtained from energy-dense, non-nutritious foods, higher than the recommended upper limit (<15%) and the levels reported in the general population (35%). Mean diet quality score was 33.5 +/- 11.8 of 73. Mean food addiction symptom score was 3.3 +/- 3.7. Prevalence of food addiction was 37%. Nutrition knowledge was lower in the FEP and UHR participants than the depression/anxiety group (48.2 +/- 13.8 and 49.5 +/- 8.2 of 88 respectively); however, this difference was not statistically significant.
   Conclusions Unhealthy dietary intake was observed in the early stages of mental illness, likely seeding future poor physical health. Further research is needed on the role of food addiction in this population, including effective intervention techniques.
C1 [Teasdale, Scott B.; Watkins, Andrew; Curtis, Jackie] South Eastern Sydney Local Hlth Dist, Keeping Body Mind Program, Sydney, NSW, Australia.
   [Teasdale, Scott B.; Curtis, Jackie; Ward, Philip B.] Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia.
   [Hayes, Tegan; Hsia, Cin Y.] Univ Sydney, Dept Nutr & Dietet, Sydney, NSW, Australia.
   [Watkins, Andrew] Univ Technol Sydney, Fac Hlth, Sydney, NSW, Australia.
   [Ward, Philip B.] Liverpool Hosp, South Western Sydney Local Hlth Dist, Ingham Inst Appl Med Res, Schizophrenia Res Unit, Sydney, NSW, Australia.
   [Burrows, Tracy L.] Univ Newcastle, Sch Hlth Sci, Newcastle, NSW, Australia.
   [Burrows, Tracy L.] Univ Newcastle, Prior Res Ctr Phys Act & Nutr, Newcastle, NSW, Australia.
C3 South Eastern Sydney Local Health District; University of New South
   Wales Sydney; University of Sydney; University of Technology Sydney;
   Liverpool Hospital; Ingham Institute for Applied Medical Research; South
   Western Sydney Local Health District; University of Newcastle;
   University of Newcastle
RP Teasdale, SB (corresponding author), Keeping Body Mind Program, 26 Llandaff St, Sydney, NSW 2022, Australia.
EM scottbteasdale@gmail.com
RI Curtis, Jackie/J-5789-2019; Teasdale, Scott/AFP-0676-2022; Ward,
   Philip/JCE-6293-2023; Burrows, Tracy/G-7802-2013
OI Ward, Philip/0000-0002-5779-7722; Watkins, Andrew/0000-0003-3452-8682;
   Curtis, Jackie/0000-0001-6884-0098; Teasdale, Scott/0000-0001-6769-8421;
   Burrows, Tracy/0000-0002-1431-7864
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alvarez-Jiménez M, 2008, CNS DRUGS, V22, P547, DOI 10.2165/00023210-200822070-00002
   [Anonymous], 2011, AUSTR HLTH SURV NUTR
   Association AP, 2013, Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
   Burrows T, 2018, J HUM NUTR DIET, V31, P544, DOI 10.1111/jhn.12532
   Burrows T, 2012, EUR J CLIN NUTR, V66, P825, DOI 10.1038/ejcn.2012.26
   Burrows TL, 2015, NUTRIENTS, V7, P3240, DOI 10.3390/nu7053240
   Collins CE, 2015, NUTRIENTS, V7, P785, DOI 10.3390/nu7020785
   Firth J, 2019, PSYCHOSOM MED, V81, P265, DOI 10.1097/PSY.0000000000000673
   Fountaine RJ, 2010, OBESITY, V18, P1646, DOI 10.1038/oby.2010.6
   Gearhardt AN, 2016, PSYCHOL ADDICT BEHAV, V30, P113, DOI 10.1037/adb0000136
   GOLDBERG GR, 1991, EUR J CLIN NUTR, V45, P569
   Goluza I, 2017, ASIAN J PSYCHIATR, V27, P81, DOI 10.1016/j.ajp.2017.02.022
   Hendrie GA, 2008, NUTR DIET, V65, P72, DOI 10.1111/j.1747-0080.2007.00218.x
   Hendrie GA, 2008, PUBLIC HEALTH NUTR, V11, P1365, DOI 10.1017/S1368980008003042
   Kessler RC, 2005, ARCH GEN PSYCHIAT, V62, P593, DOI 10.1001/archpsyc.62.6.593
   Kliemann N, 2016, EUR J CLIN NUTR, V70, P1174, DOI 10.1038/ejcn.2016.87
   Knolle-Veentjer S, 2008, J PSYCHIATR RES, V42, P98, DOI 10.1016/j.jpsychires.2006.10.003
   Lachat C, 2016, NUTR BULL, V41, P240, DOI 10.1111/nbu.12217
   Lawrence D, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f2539
   Martin MS, 2016, PUBLIC HEALTH, V132, P86, DOI 10.1016/j.puhe.2015.11.014
   National Health and Medical Research Council, 2013, AUSTR DIET GUID
   Osborn DPJ, 2007, SOC PSYCH PSYCH EPID, V42, P787, DOI 10.1007/s00127-007-0247-3
   Parmenter K, 1999, EUR J CLIN NUTR, V53, P298, DOI 10.1038/sj.ejcn.1600726
   Shiers D, 2014, LANCET PSYCHIAT, V1, P492, DOI 10.1016/S2215-0366(14)00072-8
   Teasdale SB, 2019, BRIT J PSYCHIAT, V214, P251, DOI 10.1192/bjp.2019.20
   Teasdale SB, 2018, AUSTRALAS PSYCHIATRY, V26, P47, DOI 10.1177/1039856217726690
   Teasdale SB, 2017, BRIT J PSYCHIAT, V210, P110, DOI 10.1192/bjp.bp.115.177139
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   World Health Organization, 1995, Physical Status: The Use and Interpretation of Anthropometry
NR 30
TC 25
Z9 26
U1 1
U2 26
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1446-6368
EI 1747-0080
J9 NUTR DIET
JI Nutr. Diet.
PD JUL
PY 2020
VL 77
IS 3
BP 315
EP 322
DI 10.1111/1747-0080.12550
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA LS8BM
UT WOS:000536606100004
PM 31243895
DA 2025-06-11
ER

PT J
AU Dallongeville, J
   Cottel, D
   Ferrières, J
   Arveiler, D
   Bingham, A
   Ruidavets, JB
   Haas, B
   Ducimetière, P
   Amouyel, P
AF Dallongeville, J
   Cottel, D
   Ferrières, J
   Arveiler, D
   Bingham, A
   Ruidavets, JB
   Haas, B
   Ducimetière, P
   Amouyel, P
TI Household income is associated with the risk of metabolic syndrome in a
   sex-specific manner
SO DIABETES CARE
LA English
DT Article
ID ACUTE PSYCHOLOGICAL STRESS; SOCIOECONOMIC-STATUS; INSULIN-RESISTANCE;
   PHYSICAL-ACTIVITY; NUTRITION KNOWLEDGE; HEALTH; OBESITY; COMPONENTS;
   MORTALITY; FEATURES
AB OBJECTIVE - To assess the relationship between household income and metabolic syndrome in men and women. 695 men and 1,664 women.
   RESEARCH DESIGN AND METHODS - A total of 1,695 women aged 35-64 years, from three distinct geographical areas of France were investigated. Waist girth, plasma triglycerides, HDL cholesterol, glucose, and systolic blood pressure were used to define Metabolic syndrome according to the National Cholesterol Education Program (NCEP)/ Adult Treatment Panel III (ATPIII) guidelines. Household income, educational level, occupational category, working status, consumption of psychotropic drugs, accommodation status, household composition, physical activity at work and during leisure, alcohol consumption, and smoking habits were recorded with a standardized questionnaire.
   RESULTS - There were 390 (23.0%) men and 381 (16.9%) women who satisfied NCEP/ATPIII criteria for metabolic syndrome. Household income (P < 0.0001) and consumption of psychotropic drugs (P = 0.0005) were associated with metabolic syndrome in women but not in men. In contrast, educational level, occupational category, working status, and accomodation status were associated with Metabolic syndrome in both men and women. After adjustment on lifestyle variables, household income (interaction P < 0.004) remained inversely associated with metabolic syndrome in women but not in men.
   CONCLUSIONS - These data suggest that limited household income, which reflects a complex unfavorable social and economic environment, may increase the risk of metabolic syndrome in a sex-specific manner.
   Diabetes Care 28:409-415. 2005.
C1 Inst Pasteur, INSERM, U508, F-59019 Lille, France.
   Fac Med Purpan, INSERM, Toulouse, France.
   Lab Epidemiol & Sante Publ, Strasbourg, France.
   Hop Paul Brousse, INSERM, Villejuif, France.
   Univ Lille 2, Fac Med, F-59800 Lille, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Pasteur Network; Universite de Lille; Institut Pasteur Lille; Universite
   de Toulouse; Universite Toulouse III - Paul Sabatier; Institut National
   de la Sante et de la Recherche Medicale (Inserm); Assistance Publique
   Hopitaux Paris (APHP); Hopital Universitaire Paul-Brousse - APHP;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Lille
RP Inst Pasteur, INSERM, U508, 1 Rue Pr Calmette, F-59019 Lille, France.
EM jean.dallongeville@pasteur-lille.fr
RI Amouyel, Philippe/D-3662-2018; Ferrieres, Jean/S-7993-2016
OI Ferrieres, Jean/0000-0001-6144-1297; Amouyel,
   Philippe/0000-0001-9088-234X
CR Booth SL, 2001, NUTR REV, V59, pS21, DOI 10.1111/j.1753-4887.2001.tb06983.x
   Brunner E, 1997, BMJ-BRIT MED J, V314, P1472, DOI 10.1136/bmj.314.7092.1472
   Brunner EJ, 1997, DIABETOLOGIA, V40, P1341, DOI 10.1007/s001250050830
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Dallongeville J, 2001, PUBLIC HEALTH NUTR, V4, P27, DOI 10.1079/PHN200052
   Darmon N, 2004, PUBLIC HEALTH NUTR, V7, P21, DOI 10.1079/PHN2003512
   De Irala-Estévez J, 2000, EUR J CLIN NUTR, V54, P706, DOI 10.1038/sj.ejcn.1601080
   Drewnowski A, 2004, AM J CLIN NUTR, V79, P6
   Ecob R, 1999, SOC SCI MED, V48, P693, DOI 10.1016/S0277-9536(98)00385-2
   Everson SA, 2002, J PSYCHOSOM RES, V53, P891, DOI 10.1016/S0022-3999(02)00303-3
   Grundy SM, 2004, ARTERIOSCL THROM VAS, V24, pE13, DOI 10.1161/01.ATV.0000111245.75752.C6
   Hanson RL, 2002, DIABETES, V51, P3120, DOI 10.2337/diabetes.51.10.3120
   Hjartaker A, 1998, EUR J CLIN NUTR, V52, P565, DOI 10.1038/sj.ejcn.1600608
   Horsten M, 1999, J CARDIOVASC RISK, V6, P391
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   JEFFERY RW, 1989, INT J OBESITY, V13, P59
   Kaplan GA, 1999, PREV MED, V29, pS30, DOI 10.1006/pmed.1999.0540
   Laaksonen DE, 2002, DIABETES CARE, V25, P1612, DOI 10.2337/diacare.25.9.1612
   Laaksonen DE, 2002, AM J EPIDEMIOL, V156, P1070, DOI 10.1093/aje/kwf145
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lidfeldt J, 2003, DIABETES OBES METAB, V5, P106, DOI 10.1046/j.1463-1326.2003.00250.x
   LUEPKER RV, 1993, CIRCULATION, V88, P2172, DOI 10.1161/01.CIR.88.5.2172
   Mayer-Davis EJ, 1998, JAMA-J AM MED ASSOC, V279, P669, DOI 10.1001/jama.279.9.669
   MCCANN BS, 1995, PSYCHOSOM MED, V57, P165, DOI 10.1097/00006842-199503000-00009
   MULDOON MF, 1995, ARCH INTERN MED, V155, P615, DOI 10.1001/archinte.155.6.615
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Rosell MS, 2003, AM J CLIN NUTR, V78, P84, DOI 10.1093/ajcn/78.1.84
   Rosmond R, 1999, INT J OBESITY, V23, P138, DOI 10.1038/sj.ijo.0800782
   Roux AVD, 2002, DIABETES CARE, V25, P1976, DOI 10.2337/diacare.25.11.1976
   Sarlio-Lähteenkorva S, 1999, INT J EPIDEMIOL, V28, P445, DOI 10.1093/ije/28.3.445
   Timar O, 2000, CAN J CARDIOL, V16, P779
   Wamala SP, 1999, DIABETES CARE, V22, P1999, DOI 10.2337/diacare.22.12.1999
   Wardle J, 2002, AM J PUBLIC HEALTH, V92, P1299, DOI 10.2105/AJPH.92.8.1299
   Wardle J, 2000, APPETITE, V34, P269, DOI 10.1006/appe.1999.0311
   Williams DEM, 2000, BRIT J NUTR, V83, P257, DOI 10.1017/S0007114500000337
   ,, 1988, Journal of Clinical Epidemiology, V41, P105, DOI 10.1016/0895-4356(88)90084-4
NR 37
TC 130
Z9 143
U1 1
U2 5
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD FEB
PY 2005
VL 28
IS 2
BP 409
EP 415
DI 10.2337/diacare.28.2.409
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 891WY
UT WOS:000226612900029
PM 15677801
OA Bronze
DA 2025-06-11
ER

PT J
AU Li, A
   Zhou, Q
   Mei, YY
   Zhao, JX
   Zhao, MD
   Xu, J
   Ge, XY
   Xu, Q
AF Li, Ang
   Zhou, Quan
   Mei, Yayuan
   Zhao, Jiaxin
   Zhao, Meiduo
   Xu, Jing
   Ge, Xiaoyu
   Xu, Qun
TI Novel Strategies for Assessing Associations Between Selenium Biomarkers
   and Cardiometabolic Risk Factors: Concentration, Visit-to-Visit
   Variability, or Individual Mean? Evidence From a Repeated-Measures Study
   of Older Adults With High Selenium
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE concentration; visit-to-visit variability (VVV); individual mean (IM);
   cardiometabolic risk factors; selenium
ID SERUM SELENIUM; METABOLIC SYNDROME; BLOOD-PRESSURE; ENVIRONMENTAL
   EXPOSURE; CARDIOVASCULAR EVENTS; WAIST CIRCUMFERENCE; OXIDATIVE STRESS;
   LIPID-METABOLISM; HYPERTENSION; CREATININE
AB Background and AimsPrevious studies have focused only on the cardiometabolic effects of selenium concentrations. We explored whether selenium levels and their visit-to-visit variability (VVV) and individual mean (IM) are independently associated with cardiometabolic risk factors. MethodsA three-wave repeated-measures study of older adults with high selenium (n = 201) was conducted in Beijing from 2016 to 2018. Whole blood selenium and urinary selenium concentrations were measured. VVV and IM were used to profile the homeostasis of the selenium biomarkers. Four indicators, namely standard deviation, coefficient of variation, average real variability, and variability independent of the mean, were employed to characterize VVV. We considered 13 cardiometabolic factors: four lipid profile indicators, three blood pressure indices, glucose, uric acid, waistline, hipline, waist-hip ratio, and sex-specific metabolic syndrome score. Linear mixed-effects regression models with random intercepts for the participants were employed to explore the associations of the selenium concentrations, VVV, and IM with the cardiometabolic factors. ResultsThe geometric mean whole blood and urinary selenium levels were 134.30 and 18.00 mu g/L, respectively. Selenium concentrations were significantly associated with numerous cardiometabolic factors. Specifically, whole blood selenium was positively associated with total cholesterol [0.22, 95% confidence interval (CI): 0.12, 0.33], low-density lipoprotein cholesterol (LDL-C; 0.28, 95% CI: 0.13, 0.42), glucose (0.22, 95% CI: 0.10, 0.34), and uric acid (0.16, 95% CI: 0.04, 0.28). After adjustment for VVV, the IM of whole blood selenium was positively correlated with total cholesterol (0.002, 95% CI: 0.001, 0.004), triglycerides (0.007, 95% CI: 0.004, 0.011), and LDL-C (0.002, 95% CI: 0.000, 0.004). However, we did not observe any robust associations between the VVV of the selenium biomarkers and cardiometabolic risk factors after adjustment for IM. ConclusionOur findings suggest that selenium concentrations and their IMs are significantly associated with cardiometabolic risk factors among older adults with high selenium. Longer repeated-measures studies among the general population are required to validate our findings and elucidate the relevant underlying mechanisms.
C1 [Li, Ang; Zhou, Quan; Mei, Yayuan; Zhao, Jiaxin; Zhao, Meiduo; Xu, Jing; Ge, Xiaoyu; Xu, Qun] Inst Basic Med Sci Chinese Acad Med Sci, Sch Basic Med Peking Union Med Coll, Dept Epidemiol & Biostat, Beijing, Peoples R China.
   [Li, Ang; Zhou, Quan; Mei, Yayuan; Zhao, Jiaxin; Zhao, Meiduo; Xu, Jing; Ge, Xiaoyu; Xu, Qun] Chinese Acad Med Sci, Peking Union Med Coll, Ctr Environm & Hlth Sci, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College
RP Xu, Q (corresponding author), Inst Basic Med Sci Chinese Acad Med Sci, Sch Basic Med Peking Union Med Coll, Dept Epidemiol & Biostat, Beijing, Peoples R China.; Xu, Q (corresponding author), Chinese Acad Med Sci, Peking Union Med Coll, Ctr Environm & Hlth Sci, Beijing, Peoples R China.
EM xuqun@ibms.cams.cn
RI Xu, Jing/GXN-0678-2022; Zhou, Quan/D-6155-2012
OI Li, Ang/0000-0002-4439-7834
CR Abu-Farha M, 2014, CARDIOVASC DIABETOL, V13, DOI 10.1186/1475-2840-13-76
   Alajbeg IZ, 2017, DIS MARKERS, V2017, DOI 10.1155/2017/2697464
   Amer Diabet Assoc, 2014, DIABETES CARE, V37, pS14, DOI 10.2337/dc14-S014
   Anurag P, 2002, DIABETES OBES METAB, V4, P36, DOI 10.1046/j.1463-1326.2002.00178.x
   Asayama K, 2015, HYPERTENS RES, V38, P97, DOI 10.1038/hr.2014.153
   Aylward LL, 2014, J TOXICOL ENV HEAL B, V17, P45, DOI 10.1080/10937404.2013.864250
   Barr DB, 2005, ENVIRON HEALTH PERSP, V113, P192, DOI 10.1289/ehp.7337
   Bizerea-Moga TO, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051497
   Bleys J, 2008, ARCH INTERN MED, V168, P404, DOI 10.1001/archinternmed.2007.74
   Bulka CM, 2019, ENVIRON POLLUT, V248, P28, DOI 10.1016/j.envpol.2019.01.129
   Bulka CM, 2017, ENVIRON HEALTH PERSP, V125, DOI 10.1289/EHP1202
   Center for Disease Control and Prevention, 2019, National Report on Human Exposure to Environmental Chemicals
   Chen HG, 2019, BRIT J NUTR, V122, P343, DOI 10.1017/S0007114519001193
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   Christensen K, 2015, ENVIRON RES, V140, P76, DOI 10.1016/j.envres.2015.03.020
   Cicchetti DV., 1994, Psychol Assess, V6, P284, DOI DOI 10.1037/1040-3590.6.4.284
   Combs GF, 2015, NUTRIENTS, V7, P2209, DOI 10.3390/nu7042209
   de Koning L, 2007, EUR HEART J, V28, P850, DOI 10.1093/eurheartj/ehm026
   DeBoer MD, 2017, DIABET METAB SYND OB, V10, P65, DOI 10.2147/DMSO.S101624
   DeBoer MD, 2015, J AM COLL CARDIOL, V66, P756, DOI 10.1016/j.jacc.2015.05.061
   Echouffo-Tcheugui JB, 2019, DIABETES CARE, V42, P486, DOI 10.2337/dc18-1430
   Fabbri E, 2015, J AM MED DIR ASSOC, V16, P640, DOI 10.1016/j.jamda.2015.03.013
   Fang CC, 2019, J TRACE ELEM MED BIO, V52, P209, DOI 10.1016/j.jtemb.2018.12.017
   Gerardo B, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17176051
   González-Estecha M, 2017, J TRACE ELEM MED BIO, V43, P93, DOI 10.1016/j.jtemb.2016.12.002
   GRIFFITHS NM, 1976, BRIT J NUTR, V35, P373, DOI 10.1079/BJN19760043
   Gu Y Q, 2020, Zhonghua Liu Xing Bing Xue Za Zhi, V41, P1145, DOI 10.3760/cma.j.cn112338-20200110-00027
   [郭莉 Guo Li], 2012, [现代地质, Geoscience], V26, P859
   Gurka MJ, 2014, METABOLISM, V63, P218, DOI 10.1016/j.metabol.2013.10.006
   He HJ, 2020, FRONT PUBLIC HEALTH, V8, DOI 10.3389/fpubh.2020.00177
   Hoet P, 2016, J EXPO SCI ENV EPID, V26, P296, DOI 10.1038/jes.2015.23
   Hurrle S, 2017, BIOMED J, V40, P257, DOI 10.1016/j.bj.2017.06.007
   IYENGAR GV, 1987, BIOL TRACE ELEM RES, V12, P263, DOI 10.1007/BF02796686
   Jafari M, 2019, CELL J, V20, P604, DOI 10.22074/cellj.2019.5992
   Joint committee for guideline revision, 2018, J Geriatr Cardiol, V15, P1, DOI 10.11909/j.issn.1671-5411.2018.01.011
   Ju W, 2018, CLIN NUTR, V37, P1512, DOI 10.1016/j.clnu.2017.08.025
   Kohler LN, 2018, NUTRIENTS, V10, DOI 10.3390/nu10121924
   Kraus WE, 2019, LANCET DIABETES ENDO, V7, P673, DOI 10.1016/S2213-8587(19)30151-2
   Labunskyy VM, 2011, ANTIOXID REDOX SIGN, V14, P2327, DOI 10.1089/ars.2010.3526
   Laclaustra M, 2009, CIRC-CARDIOVASC QUAL, V2, P369, DOI 10.1161/CIRCOUTCOMES.108.831552
   Laclaustra M, 2009, ENVIRON HEALTH PERSP, V117, P1409, DOI 10.1289/ehp.0900704
   Lee I, 2021, ENVIRON INT, V146, DOI 10.1016/j.envint.2020.106227
   Li A, 2021, SCI TOTAL ENVIRON, V761, DOI 10.1016/j.scitotenv.2020.143308
   Li A, 2019, ENVIRON INT, V133, DOI 10.1016/j.envint.2019.105135
   Li Z, 2018, J TRACE ELEM MED BIO, V45, P64, DOI 10.1016/j.jtemb.2017.09.023
   Lin JJ, 2021, J TRACE ELEM MED BIO, V63, DOI 10.1016/j.jtemb.2020.126660
   Liu SW, 2017, J EPIDEMIOL COMMUN H, V71, P154, DOI 10.1136/jech-2016-207805
   Lu CW, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020477
   Ma XY, 2020, BIOL TRACE ELEM RES, V197, P43, DOI 10.1007/s12011-019-01979-x
   Magnussen CG, 2016, J PEDIATR-US, V171, P97, DOI 10.1016/j.jpeds.2015.10.093
   Mazidi M, 2018, ANGIOLOGY, V69, P438, DOI 10.1177/0003319717729288
   Mehdi Y, 2013, MOLECULES, V18, P3292, DOI 10.3390/molecules18033292
   Melgarejo JD, 2021, HYPERTENSION, V77, P39, DOI 10.1161/HYPERTENSIONAHA.120.14929
   Nishida C, 2010, EUR J CLIN NUTR, V64, P2, DOI 10.1038/ejcn.2009.139
   Nwabuo CC, 2020, JAMA CARDIOL, V5, P795, DOI 10.1001/jamacardio.2020.0799
   O'Brien Katie M, 2017, Curr Environ Health Rep, V4, P44, DOI 10.1007/s40572-017-0122-7
   O'Brien KM, 2016, ENVIRON HEALTH PERSP, V124, P220, DOI 10.1289/ehp.1509693
   Parascandola M, 2019, TRANSL LUNG CANCER R, V8, pS21, DOI 10.21037/tlcr.2019.03.12
   Pieczynska J, 2019, J TRACE ELEM MED BIO, V54, P110, DOI 10.1016/j.jtemb.2019.04.010
   Puddu PE, 2014, INT J CARDIOL, V171, P361, DOI 10.1016/j.ijcard.2013.12.029
   Qin HB, 2013, ENVIRON INT, V52, P66, DOI 10.1016/j.envint.2012.12.003
   Rayman MP, 2012, LANCET, V379, P1256, DOI 10.1016/S0140-6736(11)61452-9
   Republic of Kenya, 2018, Kenya Food Composition Tables, V1st ed.
   Retondario A, 2019, CLIN NUTR, V38, P603, DOI 10.1016/j.clnu.2018.02.021
   Roth GA, 2020, J AM COLL CARDIOL, V76, P2982, DOI 10.1016/j.jacc.2020.11.010
   Rothwell PM, 2010, LANCET, V375, P938, DOI 10.1016/S0140-6736(10)60309-1
   Sánchez C, 2010, SCI TOTAL ENVIRON, V408, P1014, DOI 10.1016/j.scitotenv.2009.11.041
   Singh GM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0065174
   Stranges S, 2011, J INTERN MED, V270, P469, DOI 10.1111/j.1365-2796.2011.02398.x
   Stranges S, 2011, ATHEROSCLEROSIS, V217, P274, DOI 10.1016/j.atherosclerosis.2011.03.027
   Stranges S, 2010, J NUTR, V140, P81, DOI 10.3945/jn.109.111252
   Textor J, 2016, INT J EPIDEMIOL, V45, P1887, DOI 10.1093/ije/dyw341
   Textor J, 2011, EPIDEMIOLOGY, V22, P745, DOI 10.1097/EDE.0b013e318225c2be
   Thomson CD, 2004, EUR J CLIN NUTR, V58, P391, DOI 10.1038/sj.ejcn.1601800
   Vinceti M, 2018, EUR J EPIDEMIOL, V33, P789, DOI 10.1007/s10654-018-0422-8
   Wan EYF, 2020, DIABETES OBES METAB, V22, P1777, DOI 10.1111/dom.14093
   Wang N, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/7478523
   Wang T, 2022, CHEMOSPHERE, V287, DOI 10.1016/j.chemosphere.2021.132305
   Wang YX, 2016, ENVIRON HEALTH PERSP, V124, P468, DOI 10.1289/ehp.1409551
   Wang Y, 2020, REDOX BIOL, V37, DOI 10.1016/j.redox.2020.101709
   Weihrauch-Blüher S, 2019, METABOLISM, V92, P147, DOI 10.1016/j.metabol.2018.12.001
   Whitlock G, 2009, LANCET, V373, P1083, DOI 10.1016/S0140-6736(09)60318-4
   Wu WX, 2018, SCI TOTAL ENVIRON, V622, P184, DOI 10.1016/j.scitotenv.2017.11.343
   Wu WX, 2018, ENVIRON POLLUT, V233, P670, DOI 10.1016/j.envpol.2017.10.111
   Xia Zhiwei, 2016, Wei Sheng Yan Jiu, V45, P388
   Yamagishi S, 2008, CURR MED CHEM, V15, P172, DOI 10.2174/092986708783330557
   Yang CD, 2020, CARDIOVASC DIABETOL, V19, DOI 10.1186/s12933-020-01112-6
   Yu ZB, 2020, DIABETOLOGIA, V63, P85, DOI 10.1007/s00125-019-04986-8
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
   Zeng HW, 2009, MOLECULES, V14, P1263, DOI 10.3390/molecules14031263
   Zhao ZP, 2016, J NUTR, V146, P1625, DOI 10.3945/jn.116.229955
   Zhenping Z., 2020, CHINA CDC WEEKLY, V2, P98, DOI [10.46234/ccdcw2020.029, DOI 10.46234/CCDCW2020.029]
   Zhong QQ, 2018, NUTRIENTS, V10, DOI 10.3390/nu10060727
   Zhou L, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/5343014
NR 94
TC 12
Z9 13
U1 0
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD MAY 30
PY 2022
VL 9
AR 838613
DI 10.3389/fnut.2022.838613
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 2D1FE
UT WOS:000811300900001
PM 35711534
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lankinen, V
   Fröjd, S
   Marttunen, M
   Kaltiala-Heino, R
AF Lankinen, Vilma
   Frojd, Sari
   Marttunen, Mauri
   Kaltiala-Heino, Riittakerttu
TI Perceived rather than actual overweight is associated with mental health
   problems in adolescence
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Overweight; perceived overweight; adolescent; mental health
ID BODY-MASS INDEX; SOCIAL PHOBIA INVENTORY; METABOLIC SYNDROME PHENOTYPE;
   CARDIOVASCULAR RISK-FACTORS; BECK DEPRESSION INVENTORY; LOW SELF-ESTEEM;
   CHILDHOOD OVERWEIGHT; COMMUNITY SAMPLE; SCHOOL-CHILDREN; WEIGHT STATUS
AB Background: Overweight and perceived overweight are common among adolescents. The nature of the relationship between overweight/perceived overweight and mental health problems is still unclear.Aims: The aim of this study was to examine whether actual overweight, perceived overweight or both are associated with internalizing and externalizing disorders among adolescents.Methods: Data were collected by two similar school surveys in all Finnish-speaking secondary schools in Tampere (population 200,000) in the academic years 2002-2003 and 2012-2013. A total of 2775 acceptable responses were received. All the analyses were carried out separately for girls and boys. Mean age of the respondents was 15.6 years.Results: In multivariate analyses perceived overweight, not actual weight, was significantly associated with higher risk of self-reported depression (OR: 4.3, 95% CI: 2.9-6.3, p<.001) and self-reported conduct disorder (OR: 2.3, 95% CI: 1.6-3.3, p<.001) in girls and with higher risk of self-reported depression (OR: 3.26, 95% CI: 1.65-6.4, p=.001) and self-reported social phobia (OR: 2.4, 95% CI: 1.0-5.6, p=.05) in boys.Conclusion: Perceived overweight rather than actual weight status is associated with both internalizing and externalizing mental health problems in adolescents.
C1 [Lankinen, Vilma] Univ Tampere, Fac Med, Tampere, Finland.
   [Frojd, Sari] Univ Tampere, Hlth Sci Unit, Fac Social Sci, Tampere, Finland.
   [Marttunen, Mauri] Natl Inst Hlth & Welf, Dept Hlth, Mental Hlth Unit, Helsinki, Finland.
   [Marttunen, Mauri] Univ Helsinki, Dept Adolescent Psychiat, Helsinki, Finland.
   [Kaltiala-Heino, Riittakerttu] Univ Tampere, Adolescent Psychiat, Fac Med, Tampere, Finland.
C3 Tampere University; Tampere University; Finland National Institute for
   Health & Welfare; University of Helsinki; Tampere University
RP Lankinen, V (corresponding author), Univ Tampere, Fac Med, Tampere, Finland.
EM lankinen.vilma.l@student.uta.fi
RI Fröjd, Sari/AAF-7707-2020; Kaltiala, Riittakerttu/T-9411-2019
OI Lankinen, Vilma/0000-0002-3374-8686; Kaltiala,
   Riittakerttu/0000-0002-2783-3892; Frojd, Sari/0000-0002-6383-9028
FU Pirkanmaa Hospital District Research Grant [9P018]
FX Pirkanmaa Hospital District Research Grant 9P018.
CR Achenbach T.M., 2000, ASEBA preschool forms & profiles: An integrated system of multi-informant assessment
   Almeida S, 2012, J PAEDIATR CHILD H, V48, pE165, DOI 10.1111/j.1440-1754.2012.02576.x
   Anderson SE, 2006, AMBUL PEDIATR, V6, P297, DOI 10.1016/j.ambp.2006.06.002
   ANGOLD A, 1993, AM J PSYCHIAT, V150, P1779
   Angold A, 1999, J CHILD PSYCHOL PSYC, V40, P57, DOI 10.1111/1469-7610.00424
   Barlow SE, 1998, PEDIATRICS, V102, DOI 10.1542/peds.102.3.e29
   BECK AT, 1972, POSTGRAD MED, V52, P81, DOI 10.1080/00325481.1972.11713319
   BECK AT, 1974, PSYCHOL REP, V34, P1184
   Belue R, 2009, PEDIATRICS, V123, P697, DOI 10.1542/peds.2008-0687
   Bennett DS, 1997, J AFFECT DISORDERS, V45, P127, DOI 10.1016/S0165-0327(97)00045-1
   Bradley RH, 2008, J PEDIATR-US, V153, P629, DOI 10.1016/j.jpeds.2008.05.026
   Brixval CS, 2012, EUR J PUBLIC HEALTH, V22, P126, DOI 10.1093/eurpub/ckr010
   Brown BB, 2009, HANDBOOK OF ADOLESCE
   COLE TJ, 1995, ARCH DIS CHILD, V73, P25, DOI 10.1136/adc.73.1.25
   Cole TJ, 2000, BMJ-BRIT MED J, V320, P1240, DOI 10.1136/bmj.320.7244.1240
   Connor KM, 2000, BRIT J PSYCHIAT, V176, P379, DOI 10.1192/bjp.176.4.379
   Cook S, 2003, ARCH PEDIAT ADOL MED, V157, P821, DOI 10.1001/archpedi.157.8.821
   Daniels Judi, 2005, J Pediatr Health Care, V19, P33
   Daniels SR, 2005, CIRCULATION, V111, P1999, DOI 10.1161/01.CIR.0000161369.71722.10
   Danielsen YS, 2012, OBESITY FACTS, V5, P722, DOI 10.1159/000338333
   Dockray S, 2009, J ADOLESCENT HEALTH, V45, P344, DOI 10.1016/j.jadohealth.2009.06.014
   Duarte CS, 2010, J PEDIATR-US, V156, P93, DOI 10.1016/j.jpeds.2009.06.066
   Duncan GE, 2004, DIABETES CARE, V27, P2438, DOI 10.2337/diacare.27.10.2438
   Fountoulakis KN, 2003, BMC PSYCHIATRY, V3, DOI 10.1186/1471-244X-3-21
   Franks PW, 2010, NEW ENGL J MED, V362, P485, DOI 10.1056/NEJMoa0904130
   Freedman DS, 2007, J PEDIATR-US, V150, P12, DOI 10.1016/j.jpeds.2006.08.042
   Furnham A, 2002, J PSYCHOL, V136, P581, DOI 10.1080/00223980209604820
   Greene SB., 2008, PSYCHOLOGY OF EMOTIO
   Greenwood DN, 2012, PSYCHOL POP MEDIA CU, V1, P220, DOI 10.1037/a0029411
   Grogan S., 2007, BODY IMAGE UNDERSTAN
   Hayden-Wade HA, 2005, OBES RES, V13, P1381, DOI 10.1038/oby.2005.167
   Hesketh K, 2004, INT J OBESITY, V28, P1233, DOI 10.1038/sj.ijo.0802624
   Isomaa R, 2011, BODY IMAGE, V8, P58, DOI 10.1016/j.bodyim.2010.11.005
   Jansen W, 2008, J ADOLESCENT HEALTH, V42, P128, DOI 10.1016/j.jadohealth.2007.07.015
   Johnson HS, 2006, PSYCHOL ASSESSMENT, V18, P269, DOI 10.1037/1040-3590.18.3.269
   Kaltiala-Heino R, 2003, EUR J PUBLIC HEALTH, V13, P4, DOI 10.1093/eurpub/13.1.4
   Kaltiala-Heino R, 1999, NORD J PSYCHIAT, V53, P451, DOI 10.1080/080394899427700
   Kaltiala-Heino R, 2016, CHILD ABUSE NEGLECT, V54, P33, DOI 10.1016/j.chiabu.2016.02.003
   Korczak DJ, 2014, J DEV BEHAV PEDIATR, V35, P108, DOI 10.1097/DBP.0000000000000015
   Lemstra ME, 2012, CAN J PUBLIC HEALTH, V103, P9, DOI 10.1007/BF03404061
   Loth KA, 2011, J PEDIATR PSYCHOL, V36, P216, DOI 10.1093/jpepsy/jsq026
   Lumeng JC, 2010, PEDIATRICS, V125, pE1301, DOI 10.1542/peds.2009-0774
   Maki P, 2012, SUOM LAAKARILEHTI, V67, P767
   McClure AC, 2010, ACAD PEDIATR, V10, P238, DOI 10.1016/j.acap.2010.03.007
   McClure HH, 2012, CHILD PSYCHIAT HUM D, V43, P837, DOI 10.1007/s10578-012-0299-9
   Mielialakysely Raitasalo R., 2007, SUOMEN OLOIHIN BECKI
   Mikkila Vera, 2002, Duodecim, V118, P921
   Monteiro LA, 2014, J HUM KINET, V43, P25, DOI 10.2478/hukin-2014-0086
   MOSSBERG HO, 1989, LANCET, V2, P491
   Murray J, 2010, CAN J PSYCHIAT, V55, P633, DOI 10.1177/070674371005501003
   MUST A, 1992, NEW ENGL J MED, V327, P1350, DOI 10.1056/NEJM199211053271904
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   O'Neill JL, 2007, EUR J CLIN NUTR, V61, P743, DOI 10.1038/sj.ejcn.1602580
   Patton SC, 2014, DEV PSYCHOL, V50, P2124, DOI 10.1037/a0037111
   Paxton SJ, 2006, J CLIN CHILD ADOLESC, V35, P539, DOI 10.1207/s15374424jccp3504_5
   Perrin EM, 2010, INT J EAT DISORDER, V43, P447, DOI 10.1002/eat.20710
   Ranta K, 2007, EUR PSYCHIAT, V22, P244, DOI 10.1016/j.eurpsy.2006.12.002
   Revah-Levy A, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-649
   Richardson LP, 2003, ARCH PEDIAT ADOL MED, V157, P739, DOI 10.1001/archpedi.157.8.739
   Rofey DL, 2009, CHILD PSYCHIAT HUM D, V40, P517, DOI 10.1007/s10578-009-0141-1
   Singh AS, 2008, OBES REV, V9, P474, DOI 10.1111/j.1467-789X.2008.00475.x
   Skinner AC, 2009, PEDIATRICS, V124, pE905, DOI 10.1542/peds.2009-0179
   Smith BH, 2000, J CONSULT CLIN PSYCH, V68, P489, DOI 10.1037//0022-006X.68.3.489
   Smolak Linda, 2004, Body Image, V1, P15, DOI 10.1016/S1740-1445(03)00008-1
   Sutin AR, 2015, PSYCHOL SCI, V26, P507, DOI 10.1177/0956797614566319
   Tang J, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-594
   Twells LK, 2011, BMC PEDIATR, V11, DOI 10.1186/1471-2431-11-21
   Vanhala M, 1998, BRIT MED J, V317, P319, DOI 10.1136/bmj.317.7154.319
   Viner RM, 2005, ARCH DIS CHILD, V90, P10, DOI 10.1136/adc.2003.036467
   Wang Y, 2006, INT J PEDIATR OBES, V1, P11, DOI 10.1080/17477160600586747
   Weiss R, 2004, NEW ENGL J MED, V350, P2362, DOI 10.1056/NEJMoa031049
   World Health Organization, 1995, PHYSICAL STATUS THE
NR 72
TC 16
Z9 17
U1 0
U2 13
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0803-9488
EI 1502-4725
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PY 2018
VL 72
IS 2
BP 89
EP 96
DI 10.1080/08039488.2017.1389987
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FS7MI
UT WOS:000419981300003
PM 29124989
DA 2025-06-11
ER

PT J
AU Migueles, JH
   Cadenas-Sanchez, C
   Lubans, DR
   Henriksson, P
   Torres-Lopez, LV
   Rodriguez-Ayllon, M
   Plaza-Florido, A
   Gil-Cosano, JJ
   Henriksson, H
   Escolano-Margarit, MV
   Gómez-Vida, J
   Maldonado, J
   Lof, M
   Ruiz, JR
   Labayen, I
   Ortega, FB
AF Migueles, Jairo H.
   Cadenas-Sanchez, Cristina
   Lubans, David R.
   Henriksson, Pontus
   Torres-Lopez, Lucia V.
   Rodriguez-Ayllon, Maria
   Plaza-Florido, Abel
   Gil-Cosano, Jose J.
   Henriksson, Hanna
   Escolano-Margarit, Maria Victoria
   Gomez-Vida, Jose
   Maldonado, Jose
   Lof, Marie
   Ruiz, Jonatan R.
   Labayen, Idoia
   Ortega, Francisco B.
TI Effects of an Exercise Program on Cardiometabolic and Mental Health in
   Children With Overweight or Obesity A Secondary Analysis of a Randomized
   Clinical Trial
SO JAMA NETWORK OPEN
LA English
DT Article
ID PHYSICAL-ACTIVITY; CHILDHOOD OBESITY; PEDIATRIC OBESITY; RISK;
   ADOLESCENTS; YOUTH; DEPRESSION; OUTCOMES; SCALE; LIFE
AB Importance Childhood obesity is a risk factor associated with type 2 diabetes, cardiovascular disease, and mental disorders later in life. Investigation of the parallel effects of a defined exercise program on cardiometabolic and mental health in children with overweight or obesity may provide new insights on the potential benefits of exercise on overall health.
   Objective To investigate the effects of a 20-week exercise program on cardiometabolic and mental health in children with overweight or obesity.
   Design, Setting, and Participants This secondary analysis of a parallel-group randomized clinical trial was conducted in Granada, Spain, from November 1, 2014, to June 30, 2016. Data analyses were performed between February 1, 2020, and July 14, 2022. Children with overweight or obesity aged 8 to 11 years were eligible, and the study was performed in an out-of-school context.
   Intervention The exercise program included 3 to 5 sessions/wk (90 min/session) of aerobic plus resistance training for 20 weeks. The wait-list control group continued with their usual routines.
   Main Outcomes and Measures Cardiometabolic outcomes as specified in the trial protocol included body composition (fat mass, fat-free mass, and visceral adipose tissue), physical fitness (cardiorespiratory, speed-agility, and muscular), and traditional risk factors (waist circumference, blood lipid levels, glucose levels, insulin levels, and blood pressure). Cardiometabolic risk score (z score) was calculated based on age and sex reference values for levels of triglycerides, inverted high-density lipoprotein cholesterol, and glucose, the mean of systolic and diastolic blood pressure, and waist circumference. An additional cardiometabolic risk score also included cardiorespiratory fitness. Mental health outcomes included an array of psychological well-being and ill-being indicators.
   Results The 92 participants included in the per-protocol analyses (36 girls [39%] and 56 boys [61%]) had a mean (SD) age of 10.0 (1.1) years. The exercise program reduced the cardiometabolic risk score byapproximately0.38 (95% CI, -0.74 to -0.02) SDs; decreased low-density lipoprotein cholesterol level by -7.00 (95% CI, -14.27 to 0.37) mg/dL (to convert to mmol/L, multiply by 0.0259), body mass index (calculated as weight in kilograms divided by height in meters squared) by -0.59 (95% CI, -1.06 to -0.12), fat mass index by -0.67 (95% CI, -1.01 to -0.33), and visceral adipose tissue by -31.44 (95% CI, -58.99 to -3.90) g; and improved cardiorespiratory fitness by 2.75 (95% CI, 0.22-5.28) laps in the exercise group compared with the control group. No effects were observed on mental health outcomes.
   Conclusions and Relevance In this secondary analysis of a randomized clinical trial, an aerobic plus resistance exercise program improved cardiometabolic health in children with overweight or obesity but had no effect on mental health.
C1 [Migueles, Jairo H.; Cadenas-Sanchez, Cristina; Torres-Lopez, Lucia V.; Rodriguez-Ayllon, Maria; Plaza-Florido, Abel; Gil-Cosano, Jose J.; Ruiz, Jonatan R.; Ortega, Francisco B.] Univ Granada, Sport & Hlth Univ Res Inst, Fac Sport Sci, Dept Phys Educ & Sports, Granada, Spain.
   [Migueles, Jairo H.; Lof, Marie; Ortega, Francisco B.] Karolinska Inst, Dept Biosci & Nutr, Stockholm, Sweden.
   [Cadenas-Sanchez, Cristina; Ruiz, Jonatan R.; Labayen, Idoia; Ortega, Francisco B.] Inst Salud Carlos III, CIBER Ctr Invest Biomed Red Fisiopatol Obesidad &, Granada, Spain.
   [Cadenas-Sanchez, Cristina] Stanford Univ, Dept Cardiol, Stanford, CA USA.
   [Cadenas-Sanchez, Cristina] Palo Alto Hlth Care Syst, Vet Affairs Med Ctr, Palo Alto, CA USA.
   [Lubans, David R.] Univ Newcastle, Hunter Med Res Inst, Ctr Act Living & Learning, Newcastle, Australia.
   [Lubans, David R.; Ortega, Francisco B.] Univ Jyvaskyla, Fac Sport & Hlth Sci, Jyvaskyla, Finland.
   [Henriksson, Pontus; Henriksson, Hanna] Linkoping Univ, Dept Hlth Med & Caring Sci, Linkoping, Sweden.
   [Rodriguez-Ayllon, Maria] Erasmus Univ, Dept Epidemiol, Med Ctr Rotterdam, Rotterdam, Netherlands.
   [Plaza-Florido, Abel] Univ Calif Irvine, Sch Med, Dept Pediat, Pediat Exercise & Genom Res Ctr, Irvine, CA USA.
   [Gil-Cosano, Jose J.] Univ Loyola Andalucia, Dept Commun & Educ, Seville, Spain.
   [Escolano-Margarit, Maria Victoria; Gomez-Vida, Jose] San Cecilio Univ Hosp, Dept Pediatrics, Granada, Spain.
   [Maldonado, Jose] Univ Granada, Sch Med, Dept Pediat, Granada, Spain.
   [Maldonado, Jose; Ruiz, Jonatan R.] Inst Invest Biosanitaria Granada, Granada, Spain.
   [Labayen, Idoia] Univ Publ Navarra, Inst Sustainabil & Food Chain Innovat, Navarra Inst Hlth Res, Dept Hlth Sci, Pamplona, Spain.
C3 University of Granada; Karolinska Institutet; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III;
   Stanford University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Palo Alto Health Care System; University of
   Newcastle; Hunter Medical Research Institute; University of Jyvaskyla;
   Linkoping University; Erasmus University Rotterdam; Erasmus MC;
   University of California System; University of California Irvine;
   Universidad Loyola Andalucia; Hospital Universitario San Cecilio;
   University of Granada; Instituto de Investigacion Biosanitaria IBS
   Granada; Universidad Publica de Navarra; University of Navarra
RP Cadenas-Sanchez, C; Ortega, FB (corresponding author), Univ Granada, Sport & Hlth Univ,Res Inst, Fac Sport Sci, Dept Phys & Sports Educ, Carretera Alfacar S-N, Granada 18071, Spain.
EM cadenas@ugr.es; ortegaf@ugr.es
RI Migueles, Jairo/AAY-2262-2020; Löf, Marie/AAW-3323-2020; LABAYEN,
   IDOIA/C-7661-2009; Ortega, Francisco/B-4002-2010; Rodriguez-Ayllon,
   Maria/AAU-2529-2020; Lubans, David/G-7436-2013; Cadenas-Sanchez,
   Cristina/J-5635-2019; Henriksson, Pontus/AFS-6140-2022; Gil-Cosano, Jose
   J./C-5966-2019; Torres-Lopez, Lucia/AAX-2201-2020; Henriksson,
   Hanna/AAR-4250-2020; Plaza Florido, Abel Adrian/ABB-9064-2020
OI Plaza Florido, Abel Adrian/0000-0002-5374-3129; Torres Lopez, Lucia
   Victoria/0000-0002-0299-987X
FU Spanish Ministry of Economy and Competitiveness [DEP2013-47540,
   DEP2016-79512-R, DEP2017-91544-EXP, RYC-2011-09011]; Fondo Europeo de
   Desarrollo Regional (FEDER); MCIN/AEI [PID2020-120249RB-I00]; European
   Regional Development Fund (FEDER in Spanish) [B-CTS-355-UGR18]; Spanish
   Ministry of Science and Innovation [FJC2018-037925-I]; European Union
   [101028929]; Spanish Ministry of Education, Culture and Sport
   [FPU15/02645]; Swedish Research Council for Health, Working Life and
   Welfare [2012-00036]; Spanish Ministry of Science, Innovation and
   Universities [FPU17/04802]; Ramon Areces Foundation [DEP2017-91544-EXP];
   Alicia Koplowitz Foundation [ALICIAK-2018]; University of Granada; Plan
   Propio de Investigacion 2016, Excellence actions: Units of Excellence,
   Unit of Excellence on Exercise, Nutrition and Health; Junta de
   Andalucia, Consejeria de Conocimiento, Investigacion y Universidades;
   EXERNET Research Network on Exercise and Health in Special Populations
   [DEP2005-00046/ACTI]; Centro de Investigacion Biomedica en Red de
   Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos
   III, Ministerio de Ciencia e Innovacion [CB22/03/00058]; Union
   Europea-European Regional Development Fund; Marie Curie Actions (MSCA)
   [101028929] Funding Source: Marie Curie Actions (MSCA)
FX This project was supported with grants DEP2013-47540, DEP2016-79512-R,
   DEP2017-91544EXP, and RYC-2011-09011 from the Spanish Ministry of
   Economy and Competitiveness and the Fondo Europeo de Desarrollo Regional
   (FEDER) and by grant PID2020-120249RB-I00 from the MCIN/AEI
   /10.13039/501100011033. Additional funding was obtained from the
   Andalusian Operational Programme supported with grant B-CTS-355-UGR18
   from the European Regional Development Fund (FEDER in Spanish). Dr
   Cardenas-Sanchez is supported by grant FJC2018-037925-I from the Spanish
   Ministry of Science and Innovation and by a grant from the European
   Union's Horizon 2020 research and innovation programme under the Marie
   Sklodowska Curie grant agreement No 101028929. Dr Migueles is supported
   by grant FPU15/02645 from the Spanish Ministry of Education, Culture and
   Sport, and grant 2012-00036 from the Swedish Research Council for
   Health, Working Life and Welfare. Dr Torres-Lopez is supported by grant
   FPU17/04802 from the Spanish Ministry of Science, Innovation and
   Universities. Dr Rodriquez-Ayllon was funded by grant DEP2017-91544-EXP
   from the Ramon Areces Foundation. Additional support was obtained from
   grant ALICIAK-2018 from the Alicia Koplowitz Foundation, University of
   Granada, Plan Propio de Investigacion 2016, Excellence actions: Units of
   Excellence, Unit of Excellence on Exercise, Nutrition and Health, the
   Junta de Andalucia, Consejeria de Conocimiento, Investigacion y
   Universidades; and grant DEP2005-00046/ACTI from the EXERNET Research
   Network on Exercise and Health in Special Populations. This research was
   supported by grant CB22/03/00058 from the Centro de Investigacion
   Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion, Instituto
   de Salud Carlos III, Ministerio de Ciencia e Innovacion and Union
   Europea-European Regional Development Fund.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Andersen LB, 2006, LANCET, V368, P299, DOI 10.1016/S0140-6736(06)69075-2
   [Anonymous], 2001, International Standards for Anthropometric Assessment
   Artero EG, 2011, INT J SPORTS MED, V32, P159, DOI 10.1055/s-0030-1268488
   Ayer J, 2015, EUR HEART J, V36, P1371, DOI 10.1093/eurheartj/ehv089
   Bailey AP, 2018, PSYCHOL MED, V48, P1068, DOI 10.1017/S0033291717002653
   Blüher S, 2014, METABOLISM, V63, P1084, DOI 10.1016/j.metabol.2014.06.009
   Cadenas-Sanchez C, 2021, SPORTS MED, V51, P2571, DOI 10.1007/s40279-021-01520-y
   Cadenas-Sánchez C, 2016, CONTEMP CLIN TRIALS, V47, P315, DOI 10.1016/j.cct.2016.02.007
   Castro-Piñero J, 2010, BRIT J SPORT MED, V44, P934, DOI 10.1136/bjsm.2009.058321
   Chastin SFM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0139984
   Copeland KC, 2011, J CLIN ENDOCR METAB, V96, P159, DOI 10.1210/jc.2010-1642
   Cristi-Montero C, 2019, J SPORT HEALTH SCI, V8, P55, DOI 10.1016/j.jshs.2018.03.004
   Davis CL, 2020, INT J OBESITY, V44, P1152, DOI 10.1038/s41366-019-0482-1
   Davis CL, 2012, JAMA-J AM MED ASSOC, V308, P1103, DOI 10.1001/2012.jama.10762
   Evenson KR, 2008, J SPORT SCI, V26, P1557, DOI 10.1080/02640410802334196
   Ey S, 2005, J CHILD PSYCHOL PSYC, V46, P548, DOI 10.1111/j.1469-7610.2004.00372.x
   Farpour-Lambert NJ, 2009, J AM COLL CARDIOL, V54, P2396, DOI 10.1016/j.jacc.2009.08.030
   Fiuza-Luces C, 2013, PHYSIOLOGY, V28, P330, DOI 10.1152/physiol.00019.2013
   Garcia-Hermoso A, 2018, BRIT J SPORT MED, V52, P161, DOI 10.1136/bjsports-2016-096605
   Gómez-Lugo M, 2016, SPAN J PSYCHOL, V19, DOI 10.1017/sjp.2016.67
   Hildebrand M, 2017, SCAND J MED SCI SPOR, V27, P1814, DOI 10.1111/sms.12795
   Hildebrand M, 2014, MED SCI SPORT EXER, V46, P1816, DOI 10.1249/MSS.0000000000000289
   Hudda MT, 2021, JAMA NETW OPEN, V4, DOI 10.1001/jamanetworkopen.2021.8524
   Jolliffe CJ, 2007, J AM COLL CARDIOL, V49, P891, DOI 10.1016/j.jacc.2006.08.065
   Kamel M, 2018, OBES REV, V19, P1688, DOI 10.1111/obr.12748
   Kelley GA, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2019-031220
   Kelly AS, 2011, INT J PEDIATR OBES, V6, pE283, DOI 10.3109/17477166.2010.528765
   KNIGHT D, 1988, J CHILD PSYCHOL PSYC, V29, P853, DOI 10.1111/j.1469-7610.1988.tb00758.x
   Labayen I, 2020, DIABETES CARE, V43, P306, DOI 10.2337/dc19-0351
   Lang JJ, 2018, EXERC SPORT SCI REV, V46, P66, DOI 10.1249/JES.0000000000000138
   Laurent J, 1999, PSYCHOL ASSESSMENT, V11, P326, DOI 10.1037/1040-3590.11.3.326
   Léger LA, 1988, J SPORT SCI, V6, P93, DOI 10.1080/02640418808729800
   LITTLE RJA, 1988, J BUS ECON STAT, V6, P287, DOI 10.2307/1391878
   Lubans DR, 2017, INT J BEHAV NUTR PHY, V14, DOI 10.1186/s12966-017-0479-x
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Lyubomirsky S, 1999, SOC INDIC RES, V46, P137, DOI 10.1023/A:1006824100041
   Martinez I., 2003, Psicol Educ Cult, V7, P239
   Medrano M, 2020, PEDIATR DIABETES, V21, DOI 10.1111/pedi.12949
   Migueles JH, 2022, BRIT J SPORT MED, V56, P376, DOI 10.1136/bjsports-2020-103604
   Migueles JH, 2019, SCAND J MED SCI SPOR, V29, P566, DOI 10.1111/sms.13356
   Migueles JH, 2017, SPORTS MED, V47, P1821, DOI 10.1007/s40279-017-0716-0
   Migueles JH, 2022, J Meas Phys Behav, V31, P629, DOI [DOI 10.1123/JMPB.2018-0063, 10.1123/jmpb.2018-0063]
   Romero-Pérez EM, 2015, BIOTECNIA, V17, P11, DOI 10.18633/bt.v17i0.162
   Moore SA, 2015, MED SCI SPORT EXER, V47, P1755, DOI 10.1249/MSS.0000000000000588
   Nadeau KJ, 2016, DIABETES CARE, V39, P1635, DOI 10.2337/dc16-1066
   Ortega FB, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2022.27893
   Ortega FB, 2016, CIRC RES, V118, P1752, DOI 10.1161/CIRCRESAHA.115.306883
   Raghuveer G, 2020, CIRCULATION, V142, pE101, DOI 10.1161/CIR.0000000000000866
   Reynolds WM., 1998, Comprehensive Clinical Psychology, P419, DOI [DOI 10.1016/B0080-4270(73)00135-8, 10.1016/B0080-4270(73)00135-8]
   RODRIGO G, 1989, PSYCHOL REP, V65, P94, DOI 10.2466/pr0.1989.65.1.94
   Rodriguez-Ayllon M, 2019, SPORTS MED, V49, P1383, DOI 10.1007/s40279-019-01099-5
   Ross R, 2019, BRIT J SPORT MED, V53, P1141, DOI 10.1136/bjsports-2018-100328
   Ruiz JR, 2009, BRIT J SPORT MED, V43, P909, DOI 10.1136/bjsm.2008.056499
   Schwarzer R, 1995, Measures in health psychology: a users portfolio. Causal and control beliefs, V1, P35
   Seabra AC, 2014, SCAND J MED SCI SPOR, V24, P10, DOI 10.1111/sms.12268
   Sink KM, 2015, JAMA-J AM MED ASSOC, V314, P781, DOI 10.1001/jama.2015.9617
   Spielberger CD, 1970, STATE TRAIT ANXIETY
   Spruit A, 2016, CLIN PSYCHOL REV, V45, P56, DOI 10.1016/j.cpr.2016.03.006
   Stavnsbo M, 2018, ATHEROSCLEROSIS, V278, P299, DOI 10.1016/j.atherosclerosis.2018.10.003
   Thivel D, 2016, OBESITY FACTS, V9, P52, DOI 10.1159/000443687
   Tomkinson GR, 2017, BRIT J SPORT MED, V51, P1545, DOI 10.1136/bjsports-2016-095987
   Torres MVT, 2009, PSICOTHEMA, V21, P598
   U.S. Department of Health and Human Services, 2018, 2018 Physical activity guidelines advisory committee scientific report
   van Hees VT, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0142533
   van Hees VT, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-31266-z
   Weihrauch-Blüher S, 2019, METABOLISM, V92, P147, DOI 10.1016/j.metabol.2018.12.001
   Williams CF, 2019, TRANSL BEHAV MED, V9, P451, DOI 10.1093/tbm/ibz015
   World Health Organization, 2023, BMI FOR AG 5 19 YEAR
   Zucker I, 2022, DIABETOLOGIA, V65, P1473, DOI 10.1007/s00125-022-05722-5
   ,, 2010, Global recommendations on physical activity for health
NR 71
TC 20
Z9 20
U1 2
U2 32
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2574-3805
J9 JAMA NETW OPEN
JI JAMA Netw. Open
PD JUL
PY 2023
VL 6
IS 7
AR e2324839
DI 10.1001/jamanetworkopen.2023.24839
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Q7ON7
UT WOS:001059382200001
PM 37498603
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Muhtz, C
   Zyriax, BC
   Klähn, T
   Windler, E
   Otte, C
AF Muhtz, Christoph
   Zyriax, Birgit-Christiane
   Klaehn, Tilman
   Windler, Eberhard
   Otte, Christian
TI Depressive symptoms and metabolic risk: Effects of cortisol and gender
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Depression; Cortisol; Metabolic syndrome; Stress; Cardiovascular
   disease; Gender; Diabetes
ID CORONARY-HEART-DISEASE; HYPERCORTISOLEMIC DEPRESSION;
   CARDIOVASCULAR-DISEASE; MAJOR DEPRESSION; YOUNG-ADULTS; ASSOCIATION;
   PULSATILITY; DISORDERS; STRESS; HEALTH
AB We examined gender effects and the role of cortisol in the association between depressive symptoms and metabolic risk in the Stress, Atherosclerosis, and ECG Study (STRATEGY). In 215 healthy adults from the general population (n = 107 men, n = 108 women, distributed equally across four age groups, 30-70 years), we assessed depressive symptoms by the Patient Health Questionnaire (PHQ score >10) and measured variables of the metabolic syndrome: high-density lipoprotein (HDL), triglycerides, systolic and diastolic blood pressure, fasting blood glucose and waist circumference. Salivary cortisol was assessed at 08:00, 12:00, 16:00 and 22:00 h.
   Depressive symptoms were not associated with the metabolic syndrome as entity in the total sample or in men and women separately. However, women with depressive symptoms had larger waist circumferences, higher fasting blood glucose, lower HDL-cholesterol, higher diastolic blood pressure, and higher 16:00 and 22:00 h salivary cortisol compared to women without depressive symptoms. These results persisted after adjusting forage, education, smoking, and physical activity. In adjusted regression analyses, inclusion of cortisol attenuated the association between depressive symptoms and waist, fasting glucose, HDL and diastolic blood pressure in women. In men, we did not find an association between depressive symptoms and variables of the metabolic syndrome.
   In women, depressive symptoms are associated with several variables of the metabolic syndrome. Elevated afternoon and evening cortisol appear to partially mediate this association. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [Muhtz, Christoph; Otte, Christian] Univ Hosp Hamburg Eppendorf, Dept Psychiat & Psychotherapy, D-20246 Hamburg, Germany.
   [Zyriax, Birgit-Christiane; Windler, Eberhard] Univ Hosp Hamburg Eppendorf, Div Endocrinol & Metab Ageing, D-20246 Hamburg, Germany.
   [Klaehn, Tilman] Bethesda Hosp Bergedorf, Hamburg, Germany.
C3 University of Hamburg; University Medical Center Hamburg-Eppendorf;
   University of Hamburg; University Medical Center Hamburg-Eppendorf
RP Muhtz, C (corresponding author), Univ Hosp Hamburg Eppendorf, Dept Psychiat & Psychotherapy, Martinistr 52, D-20246 Hamburg, Germany.
EM cmuhtz@uke.uni-hamburg.de
RI Windler, Eberhard/AAN-3249-2020
OI Otte, Christian/0000-0002-4051-997X
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   Boyle SH, 2007, DIABETES CARE, V30, P2484, DOI 10.2337/dc07-0258
   Brown ES, 2004, BIOL PSYCHIAT, V55, P1, DOI 10.1016/S0006-3223(03)00473-6
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   Capuron L, 2008, BIOL PSYCHIAT, V64, P896, DOI 10.1016/j.biopsych.2008.05.019
   Deuschle M, 1997, J CLIN ENDOCR METAB, V82, P234, DOI 10.1210/jc.82.1.234
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Golden SH, 2008, JAMA-J AM MED ASSOC, V299, P2751, DOI 10.1001/jama.299.23.2751
   HALBREICH U, 1985, ARCH GEN PSYCHIAT, V42, P909
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Keller J, 2006, BIOL PSYCHIAT, V60, P275, DOI 10.1016/j.biopsych.2005.10.014
   KESSLER RC, 1994, ARCH GEN PSYCHIAT, V51, P8
   Kessler RC, 2003, JAMA-J AM MED ASSOC, V289, P3095, DOI 10.1001/jama.289.23.3095
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Knol MJ, 2006, DIABETOLOGIA, V49, P837, DOI 10.1007/s00125-006-0159-x
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178, DOI 10.4088/JCP.v69n0202
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Löwe B, 2004, J AFFECT DISORDERS, V78, P131, DOI 10.1016/S0165-0327(02)00237-9
   McCaffery JM, 2003, PSYCHOSOM MED, V65, P490, DOI 10.1097/01.PSY.0000041545.52924.82
   McManus D, 2005, AM J CARDIOL, V96, P1076, DOI 10.1016/j.amjcard.2005.06.037
   Moebus S, 2007, HERZ, V32, P529, DOI 10.1007/s00059-007-3025-9
   Nelson JC, 1997, AM J PSYCHIAT, V154, P1497, DOI 10.1176/ajp.154.11.1497
   Otte C, 2005, AM J PSYCHIAT, V162, P2139, DOI 10.1176/appi.ajp.162.11.2139
   Otte C, 2005, PSYCHONEUROENDOCRINO, V30, P80, DOI 10.1016/j.psyneuen.2004.06.002
   Otte C, 2004, BIOL PSYCHIAT, V56, P241, DOI 10.1016/j.biopsych.2004.06.003
   Otte C, 2007, AM J PSYCHIAT, V164, P1379, DOI 10.1176/appi.ajp.2007.06101617
   Penninx BWJH, 2007, AM J GERIAT PSYCHIAT, V15, P522, DOI 10.1097/JGP.0b013e318033ed80
   Penninx BWJH, 2001, ARCH GEN PSYCHIAT, V58, P221, DOI 10.1001/archpsyc.58.3.221
   PFOHL B, 1985, ARCH GEN PSYCHIAT, V42, P897
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Räikkönen K, 2007, DIABETES CARE, V30, P872, DOI 10.2337/dc06-1857
   Regitz-Zagrosek V, 2007, GENDER MED, V4, pS162, DOI 10.1016/S1550-8579(07)80056-8
   Rosmond R, 1998, J CLIN ENDOCR METAB, V83, P1853, DOI 10.1210/jc.83.6.1853
   Rutledge T, 2006, ARCH GEN PSYCHIAT, V63, P874, DOI 10.1001/archpsyc.63.8.874
   Rutter MK, 2005, DIABETES, V54, P3252, DOI 10.2337/diabetes.54.11.3252
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Spitzer RL, 1999, JAMA-J AM MED ASSOC, V282, P1737, DOI 10.1001/jama.282.18.1737
   Steptoe A, 2004, INT J OBESITY, V28, P1168, DOI 10.1038/sj.ijo.0802715
   Toker S, 2008, DEPRESS ANXIETY, V25, P661, DOI 10.1002/da.20379
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
   Vogelzangs N, 2007, J GERONTOL A-BIOL, V62, P563, DOI 10.1093/gerona/62.5.563
   Vogelzangs N, 2007, PSYCHONEUROENDOCRINO, V32, P151, DOI 10.1016/j.psyneuen.2006.11.009
   Weber-Hamann B, 2006, PSYCHONEUROENDOCRINO, V31, P347, DOI 10.1016/j.psyneuen.2005.08.014
   Weber-Hamann B, 2002, PSYCHOSOM MED, V64, P274, DOI 10.1097/00006842-200203000-00010
   Whooley MA, 2006, JAMA-J AM MED ASSOC, V295, P2874, DOI 10.1001/jama.295.24.2874
   Wittchen HU, 2005, EUR NEUROPSYCHOPHARM, V15, P357, DOI 10.1016/j.euroneuro.2005.04.012
   Yehuda R, 1996, BIOL PSYCHIAT, V40, P79, DOI 10.1016/0006-3223(95)00451-3
   Young EA, 2002, ENDOCRIN METAB CLIN, V31, P63, DOI 10.1016/S0889-8529(01)00002-0
   Young EA, 2001, NEUROPSYCHOPHARMACOL, V25, P267, DOI 10.1016/S0893-133X(00)00236-0
   Young EA, 2007, PSYCHONEUROENDOCRINO, V32, P503, DOI 10.1016/j.psyneuen.2007.03.003
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
NR 53
TC 53
Z9 62
U1 0
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD AUG
PY 2009
VL 34
IS 7
BP 1004
EP 1011
DI 10.1016/j.psyneuen.2009.01.016
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 463ZD
UT WOS:000267471900007
PM 19278789
DA 2025-06-11
ER

PT J
AU Murphy, JA
   Oliver, G
   Ng, CH
   Wain, C
   Magennis, J
   Opie, RS
   Bannatyne, A
   Sarris, J
AF Murphy, Jenifer A.
   Oliver, Georgina
   Ng, Chee H.
   Wain, Clinton
   Magennis, Jennifer
   Opie, Rachelle S.
   Bannatyne, Amy
   Sarris, Jerome
TI Pilot-Testing of "Healthy Body Healthy Mind": An Integrative Lifestyle
   Program for Patients With a Mental Illness and Co-morbid Metabolic
   Syndrome
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE healthy lifestyles; lifestyle medicine; metabolic syndrome; depression;
   program development
ID WEIGHT-LOSS; INTERVENTIONS; METAANALYSIS; CONSUMERS; PEOPLE; CARE
AB Background: Metabolic syndrome and co-morbid physical health conditions are highly prevalent in people with a mental illness. Modifiable lifestyle factors have been targeted to improve health outcomes. Healthy Body Healthy Mind (HBHM) program was developed to provide an integrated evidence-based program incorporating practical diet and exercise instruction; alongside meditation and mindfulness strategies, and comprehensive psychoeducation, to improve the physical and mental health of those with a mental illness.
   Methods: We report on two data points: (1) Qualitative data derived from the first HBHM program (version 1) exploring its utility and acceptance according to patient feedback; (2) Biometric and mental health data collected on the modified and enhanced 12-week HBHM program (version 2) involving a pilot of 10 participants. Mental and physical health outcomes, weight, abdominal circumference, fasting glucose, cholesterol, and triglycerides were measured at program entry and completion.
   Results: Qualitative data from HBHM version 1 provided valuable feedback to redevelop and enhance the program. At the end of the HBHM (version 2) 12-week program, a significant mean weight loss of 2 kg was achieved, p = 0.023. There was also a significant reduction in abdominal circumference (mean = 2.55 cm) and a decrease in BMI of almost one point (mean = 0.96 kg/m(2)), p = 0.046 and p = 0.019, respectively. There were no significant changes in mental health measures or on any other biometrics.
   Conclusion: Pilot data from the HBHM program found significant reductions in weight and abdominal obesity. The HBHM program could benefit from further modifications, and study replication is required using a controlled design in a larger sample.
C1 [Murphy, Jenifer A.; Oliver, Georgina; Ng, Chee H.; Sarris, Jerome] Univ Melbourne, Dept Psychiat, Professorial Unit, Melbourne Clin, Melbourne, Vic, Australia.
   [Ng, Chee H.; Wain, Clinton; Magennis, Jennifer] Melbourne Clin, Melbourne, Vic, Australia.
   [Opie, Rachelle S.] Deakin Univ, Inst Phys Act & Nutr, Sch Exercise & Nutr Sci, Geelong, Vic, Australia.
   [Bannatyne, Amy] Bond Univ, Fac Hlth Sci & Med, Gold Coast, Qld, Australia.
   [Sarris, Jerome] Western Sydney Univ, NICM Hlth Res Inst, Westmead, NSW, Australia.
C3 University of Melbourne; Deakin University; Bond University; Western
   Sydney University
RP Murphy, JA (corresponding author), Univ Melbourne, Dept Psychiat, Professorial Unit, Melbourne Clin, Melbourne, Vic, Australia.
EM j.sarris@westernsydney.edu.au
OI Ng, Chee/0000-0002-3811-2732; Opie, Rachelle/0000-0002-3816-0670;
   Bannatyne, Amy/0000-0002-4573-6199
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   Everett A, 2008, INT J MENT HEALTH, V37, P8, DOI 10.2753/IMH0020-7411370201
   Firth J, 2015, PSYCHOL MED, V45, P1343, DOI 10.1017/S0033291714003110
   John AP, 2009, MED J AUSTRALIA, V190, P176, DOI 10.5694/j.1326-5377.2009.tb02342.x
   Rodriguez-Cristobal JJ, 2017, BMC FAM PRACT, V18, DOI 10.1186/s12875-017-0644-y
   Lake James, 2017, Perm J, V21, P17, DOI 10.7812/TPP/17-024
   Lawrence D, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f2539
   LOVIBOND PF, 1995, BEHAV RES THER, V33, P335, DOI 10.1016/0005-7967(94)00075-U
   McCloughen A, 2011, INT J MENT HEALTH NU, V20, P202, DOI 10.1111/j.1447-0349.2010.00721.x
   Naslund JA, 2017, GEN HOSP PSYCHIAT, V47, P83, DOI 10.1016/j.genhosppsych.2017.04.003
   Nihalani N, 2011, J OBES, V2011, DOI 10.1155/2011/893629
   Osborn DPJ, 2007, ARCH GEN PSYCHIAT, V64, P242, DOI 10.1001/archpsyc.64.2.242
   Richards L, 2016, J PSYCHOSOC NURS MEN, V54, P46, DOI 10.3928/02793695-20151109-02
   Rodrigues MF, 2017, TRENDS PSYCHIATR PSY, V39, P207
   Rosenbaum S, 2014, J CLIN PSYCHIAT, V75, P964, DOI 10.4088/JCP.13r08765
   Singh VK, 2018, SCHIZOPHR RES, V202, P17, DOI 10.1016/j.schres.2018.06.066
   Stanley SH, 2011, AUST NZ J PSYCHIAT, V45, P824, DOI 10.3109/00048674.2011.614591
   Stelmach-Mardas M, 2014, P NUTR SOC, V73, P509, DOI 10.1017/S0029665114000718
   Stiekema APM, 2018, SCHIZOPHR RES, V199, P407, DOI 10.1016/j.schres.2018.02.053
   Teasdale SB, 2017, BRIT J PSYCHIAT, V210, P110, DOI 10.1192/bjp.bp.115.177139
NR 21
TC 11
Z9 13
U1 0
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD MAR 6
PY 2019
VL 10
AR 91
DI 10.3389/fpsyt.2019.00091
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HN9EF
UT WOS:000460501600001
PM 30894821
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lindsay, KL
   Buss, C
   Wadhwa, PD
   Entringer, S
AF Lindsay, Karen L.
   Buss, Claudia
   Wadhwa, Pathik D.
   Entringer, Sonja
TI Maternal Stress Potentiates the Effect of an Inflammatory Diet in
   Pregnancy on Maternal Concentrations of Tumor Necrosis Factor Alpha
SO NUTRIENTS
LA English
DT Article
DE dietary inflammatory index; inflammation; pregnancy; prenatal diet;
   prenatal stress; tumor necrosis factor-alpha
ID LOW-GRADE INFLAMMATION; HIGH-FAT MEALS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; PRENATAL STRESS; TNF-ALPHA; CARDIOVASCULAR-DISEASE;
   DEVELOPMENTAL ORIGINS; ENDOTHELIAL FUNCTION; DEPRESSIVE SYMPTOMS
AB Maternal inflammation during pregnancy is known to adversely impact fetal development, birth outcomes, and offspring physical and mental health. Diet and stress have been identified as important determinants of inflammation, yet their combined effects have not been examined in the context of pregnancy. The aim of this study was to examine the relationship between maternal diet with inflammatory potential and psychological stress, and to determine their interaction effect on concentrations of tumor necrosis factor (TNF)- across pregnancy. We conducted a prospective longitudinal study of n = 202 women with three assessments during pregnancy, which included: ecological momentary assessment (EMA) of maternal stress using the perceived stress scale (PSS) short version; 24-h dietary recalls from which the dietary inflammatory index (DII) was computed; and serum measurements of TNF-. Across pregnancy, higher perceived stress was associated with consumption of a more pro-inflammatory diet (r = 0.137; p < 0.05). In a linear regression model adjusted for covariates, DII was positively associated with TNF- (B = 0.093, p = 0.010). The effect of the pro-inflammatory diet on concentrations of TNF- was more pronounced in women reporting higher levels of stress (B = 0.134, p = 0.018 for DII*PSS interaction). These results highlight the need to consider nutrition and stress concurrently in the context of inflammation during pregnancy.
C1 [Lindsay, Karen L.] Univ Calif Irvine, Dept Pediat, Irvine, CA 92697 USA.
   [Lindsay, Karen L.; Buss, Claudia; Wadhwa, Pathik D.; Entringer, Sonja] Univ Calif Irvine, UC Irvine Dev Hlth & Dis Res Program, Irvine, CA 92697 USA.
   [Buss, Claudia; Entringer, Sonja] Humboldt Univ, Freie Univ Berlin, Charite Univ Med Berlin, Chariteplatz 1, D-10117 Berlin, Germany.
   [Buss, Claudia; Entringer, Sonja] BIH, Inst Med Psychol, Charitepl 1, D-10117 Berlin, Germany.
   [Wadhwa, Pathik D.] Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA 92697 USA.
   [Wadhwa, Pathik D.] Univ Calif Irvine, Dept Obstet & Gynecol, Irvine, CA 92697 USA.
C3 University of California System; University of California Irvine;
   University of California System; University of California Irvine; Berlin
   Institute of Health; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health;
   Free University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; University of California System; University
   of California Irvine; University of California System; University of
   California Irvine
RP Entringer, S (corresponding author), Univ Calif Irvine, UC Irvine Dev Hlth & Dis Res Program, Irvine, CA 92697 USA.; Entringer, S (corresponding author), Humboldt Univ, Freie Univ Berlin, Charite Univ Med Berlin, Chariteplatz 1, D-10117 Berlin, Germany.; Entringer, S (corresponding author), BIH, Inst Med Psychol, Charitepl 1, D-10117 Berlin, Germany.
EM kllindsa@uci.edu; claudia.buss@charite.de; pwadhwa@uci.edu;
   sonja.entringer@charite.de
RI Entringer, Sonja/ABB-9405-2020; Lindsay, Karen/J-4383-2019; Buss,
   Claudia/ABC-3687-2020
OI Buss, Claudia/0000-0002-8738-3133; Entringer, Sonja/0000-0002-9926-7076;
   Lindsay, Karen/0000-0002-4481-9363
FU National Center for Advancing Translational Sciences [UL1TR001414]
   Funding Source: NIH RePORTER
CR Adam TC, 2007, PHYSIOL BEHAV, V91, P449, DOI 10.1016/j.physbeh.2007.04.011
   Andersen CJ, 2015, NUTRIENTS, V7, P7889, DOI 10.3390/nu7095372
   [Anonymous], PLOS ONE
   Asemi Z, 2013, NUTRITION, V29, P619, DOI 10.1016/j.nut.2012.11.020
   Azizieh FY, 2015, MED PRIN PRACT, V24, P165, DOI 10.1159/000369363
   Barrington WE, 2014, J ACAD NUTR DIET, V114, P1791, DOI 10.1016/j.jand.2014.03.015
   Bellingrath S, 2010, BRAIN BEHAV IMMUN, V24, P1332, DOI 10.1016/j.bbi.2010.06.011
   Bodén S, 2017, NUTR J, V16, DOI 10.1186/s12937-017-0243-8
   Buss Claudia, 2012, Cerebrum, V2012, P4
   Cackovic M, 2008, OBSTET GYNECOL, V112, P93, DOI 10.1097/AOG.0b013e31817c4304
   Calleja-Agius J., 2012, INT J INTERFERON CYT, V4, P1, DOI DOI 10.2147/IJICMR.S22848
   Carpentier PA, 2011, AM J PATHOL, V178, P2802, DOI 10.1016/j.ajpath.2011.02.042
   Challier JC, 2008, PLACENTA, V29, P274, DOI 10.1016/j.placenta.2007.12.010
   Chang MW, 2015, MATERN CHILD HLTH J, V19, P1047, DOI 10.1007/s10995-014-1604-y
   Chatzi L, 2011, PUBLIC HEALTH NUTR, V14, P1663, DOI 10.1017/S1368980010003629
   Christian LM, 2014, CYTOKINE, V70, P134, DOI 10.1016/j.cyto.2014.06.018
   Christian LM, 2013, PSYCHOSOM MED, V75, P658, DOI 10.1097/PSY.0b013e31829bbc89
   Christian LM, 2012, NEUROSCI BIOBEHAV R, V36, P350, DOI 10.1016/j.neubiorev.2011.07.005
   Christian LM, 2009, BRAIN BEHAV IMMUN, V23, P750, DOI 10.1016/j.bbi.2009.02.012
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Coussons-Read ME, 2007, BRAIN BEHAV IMMUN, V21, P343, DOI 10.1016/j.bbi.2006.08.006
   Coussons-Read ME, 2005, PSYCHOSOM MED, V67, P625, DOI 10.1097/01.psy.0000170331.74960.ad
   Dahlgren J, 2001, AM J PHYSIOL-ENDOC M, V281, pE326, DOI 10.1152/ajpendo.2001.281.2.E326
   Dallman MF, 2010, TRENDS ENDOCRIN MET, V21, P159, DOI 10.1016/j.tem.2009.10.004
   Dallman MF, 2003, P NATL ACAD SCI USA, V100, P11696, DOI 10.1073/pnas.1934666100
   de Punder K, 2013, NUTRIENTS, V5, P771, DOI 10.3390/nu5030771
   Dusso A, 2010, J STEROID BIOCHEM, V121, P193, DOI 10.1016/j.jsbmb.2010.03.064
   Entringer S, 2012, J NUTR METAB, V2012, DOI 10.1155/2012/632548
   Entringer S, 2015, PSYCHONEUROENDOCRINO, V62, P366, DOI 10.1016/j.psyneuen.2015.08.019
   Epel E, 2001, PSYCHONEUROENDOCRINO, V26, P37, DOI 10.1016/S0306-4530(00)00035-4
   Ferguson KK, 2014, AM J REPROD IMMUNOL, V72, P326, DOI 10.1111/aji.12265
   Fowler ME, 2017, INT J CANCER, V141, P2215, DOI 10.1002/ijc.30922
   Freeman LR, 2011, CELL TRANSPLANT, V20, P1499, DOI 10.3727/096368910X557281
   Vilela AAF, 2014, J NUTR, V144, P1612, DOI 10.3945/jn.114.190488
   Friis CM, 2013, OBESITY, V21, pE124, DOI 10.1002/oby.20120
   Garcia-Arellano A, 2015, NUTRIENTS, V7, P4124, DOI 10.3390/nu7064124
   Gluckman PD, 2004, SCIENCE, V305, P1733, DOI 10.1126/science.1095292
   Gluckman PD, 2011, EVOL APPL, V4, P249, DOI 10.1111/j.1752-4571.2010.00164.x
   Goeden N, 2016, J NEUROSCI, V36, P6041, DOI 10.1523/JNEUROSCI.2534-15.2016
   Golding J, 2009, EPIDEMIOLOGY, V20, P598, DOI 10.1097/EDE.0b013e31819d6a57
   Gonçalves S, 2015, J HEALTH PSYCHOL, V20, P535, DOI 10.1177/1359105315573432
   Gonzalez Y, 2012, BMC IMMUNOL, V13, DOI 10.1186/1471-2172-13-19
   Grossi G, 2003, J PSYCHOSOM RES, V55, P309, DOI 10.1016/S0022-3999(02)00633-5
   Hänsel A, 2010, NEUROSCI BIOBEHAV R, V35, P115, DOI 10.1016/j.neubiorev.2009.12.012
   Hanson M, 2011, PROG BIOPHYS MOL BIO, V106, P272, DOI 10.1016/j.pbiomolbio.2010.12.008
   Hauguel-de Mouzon S, 2006, PLACENTA, V27, P794, DOI 10.1016/j.placenta.2005.08.009
   Hernandez TL, 2016, DIABETES CARE, V39, P39, DOI 10.2337/dc15-0515
   Hsiao EY, 2012, DEV NEUROBIOL, V72, P1317, DOI 10.1002/dneu.22045
   Huang CF, 2015, NEUROSCIENCE, V286, P364, DOI 10.1016/j.neuroscience.2014.12.002
   Hung TH, 2004, AM J PATHOL, V164, P1049, DOI 10.1016/S0002-9440(10)63192-6
   Hurley KM, 2005, J AM DIET ASSOC, V105, P963, DOI 10.1016/j.jada.2005.03.007
   Ingvorsen C, 2015, ACTA PHYSIOL, V214, P440, DOI 10.1111/apha.12533
   Jonakait GM, 2007, INT J DEV NEUROSCI, V25, P415, DOI 10.1016/j.ijdevneu.2007.08.017
   Kiecolt-Glaser JK, 2017, MOL PSYCHIATR, V22, P476, DOI 10.1038/mp.2016.149
   Kiecolt-Glaser JK, 2015, PSYCHONEUROENDOCRINO, V52, P239, DOI 10.1016/j.psyneuen.2014.11.018
   Kiecolt-Glaser JK, 2010, PSYCHOSOM MED, V72, P365, DOI 10.1097/PSY.0b013e3181dbf489
   Kirwan JP, 2002, DIABETES, V51, P2207, DOI 10.2337/diabetes.51.7.2207
   Laraia B, 2015, OBESITY, V23, P1303, DOI 10.1002/oby.21075
   LECOCO FR, 1964, J CLIN INVEST, V43, P237, DOI 10.1172/JCI104908
   Lindsay Karen L, 2019, Biol Psychiatry, V85, P135, DOI 10.1016/j.biopsych.2018.06.021
   Lindsay KL, 2017, ANN NUTR METAB, V70, P191, DOI 10.1159/000457136
   Lucas M, 2014, BRAIN BEHAV IMMUN, V36, P46, DOI 10.1016/j.bbi.2013.09.014
   Marques AH, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00120
   McCullough LE, 2017, EPIGENETICS-US, V12, P688, DOI 10.1080/15592294.2017.1347241
   Mikolajczyk RT, 2009, NUTR J, V8, DOI 10.1186/1475-2891-8-31
   Minihane AM, 2015, BRIT J NUTR, V114, P999, DOI 10.1017/S0007114515002093
   Mitral S, 2017, PROG NEURO-PSYCHOPH, V78, P1, DOI 10.1016/j.pnpbp.2017.05.005
   Monk C, 2013, J CHILD PSYCHOL PSYC, V54, P115, DOI 10.1111/jcpp.12000
   Moore BF, 2018, J PEDIATR-US, V195, P121, DOI 10.1016/j.jpeds.2017.10.030
   Murtha AP, 2007, OBSTET GYNECOL, V109, P121, DOI 10.1097/01.AOG.0000250474.35369.12
   Namazi N, 2018, HORM METAB RES, V50, P345, DOI 10.1055/a-0596-8204
   Neufcourt L, 2015, NUTR METAB CARDIOVAS, V25, P988, DOI 10.1016/j.numecd.2015.09.002
   Oliver G, 2000, PSYCHOSOM MED, V62, P853, DOI 10.1097/00006842-200011000-00016
   de Heredia FP, 2012, P NUTR SOC, V71, P332, DOI 10.1017/S0029665112000092
   Plata MD, 2014, REPROD BIOL ENDOCRIN, V12, P1, DOI 10.1186/1477-7827-12-80
   Ramallal R, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0135221
   Robertson SA, 2018, J REPROD IMMUNOL, V125, P80, DOI 10.1016/j.jri.2017.12.003
   Rohleder N, 2014, PSYCHOSOM MED, V76, P181, DOI 10.1097/PSY.0000000000000049
   Rohleder N, 2012, PSYCHONEUROENDOCRINO, V37, P307, DOI 10.1016/j.psyneuen.2011.12.015
   Romero R, 2006, SEMIN FETAL NEONAT M, V11, P317, DOI 10.1016/j.siny.2006.05.001
   Sanghez V, 2013, PSYCHONEUROENDOCRINO, V38, P2933, DOI 10.1016/j.psyneuen.2013.07.022
   Schwingshackl L, 2015, NUTRIENTS, V7, P7651, DOI 10.3390/nu7095356
   Segovia SA, 2017, J DEV ORIG HLTH DIS, V8, P529, DOI 10.1017/S2040174417000204
   Segovia SA, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/418975
   Sen S, 2016, J NUTR, V146, P728, DOI 10.3945/jn.115.225581
   Shelton MM, 2015, BIOL RES NURS, V17, P295, DOI 10.1177/1099800414543821
   Shiels Paul G, 2015, Curr Aging Sci, V8, P123
   Shin D, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040351
   Shivappa N, 2018, NUTRIENTS, V10, DOI 10.3390/nu10020200
   Shivappa N, 2015, BRIT J CANCER, V113, P1099, DOI 10.1038/bjc.2015.304
   Shivappa N, 2015, BRIT J NUTR, V113, P292, DOI 10.1017/S0007114514003626
   Shivappa N, 2015, BRIT J NUTR, V113, P278, DOI 10.1017/S0007114514003572
   Shivappa N, 2014, PUBLIC HEALTH NUTR, V17, P1689, DOI 10.1017/S1368980013002115
   Stewart FM, 2007, J CLIN ENDOCR METAB, V92, P969, DOI 10.1210/jc.2006-2083
   Sunderland NS, 2011, CYTOKINE, V56, P192, DOI 10.1016/j.cyto.2011.06.003
   Tabung FK, 2015, CANCER CAUSE CONTROL, V26, P399, DOI 10.1007/s10552-014-0515-y
   Tamashiro KLK, 2009, DIABETES, V58, P1116, DOI 10.2337/db08-1129
   Toder V, 2003, J ASSIST REPROD GEN, V20, P73, DOI 10.1023/A:1021740108284
   Torres SJ, 2007, NUTRITION, V23, P887, DOI 10.1016/j.nut.2007.08.008
   Tortosa-Caparrós E, 2017, CRIT REV FOOD SCI, V57, P3421, DOI 10.1080/10408398.2015.1126549
   Tzanavari T, 2010, CURR DIR AUTOIMMUN, V11, P145, DOI 10.1159/000289203
   Uusitupa M, 2013, CAN J DIABETES, V37, P327, DOI 10.1016/j.jcjd.2013.07.029
   Vohr BR, 2017, PEDIATRICS, V139, DOI [10.1542/peds.2016-2828F, 10.1542/peds.2016-2828f]
   von Känel R, 2008, J PSYCHOSOM RES, V65, P51, DOI 10.1016/j.jpsychores.2008.02.007
   Wadhwa PD, 2011, CLIN PERINATOL, V38, P351, DOI 10.1016/j.clp.2011.06.007
   Wadhwa PD, 2009, SEMIN REPROD MED, V27, P358, DOI 10.1055/s-0029-1237424
   Walsh JM, 2014, REPROD SCI, V21, P1378, DOI 10.1177/1933719114525275
   Wirth MD, 2014, J OCCUP ENVIRON MED, V56, P986, DOI 10.1097/JOM.0000000000000213
   Wood LG, 2015, CLIN EXP ALLERGY, V45, P177, DOI 10.1111/cea.12323
   Zellner DA, 2006, PHYSIOL BEHAV, V87, P789, DOI 10.1016/j.physbeh.2006.01.014
NR 110
TC 22
Z9 28
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2018
VL 10
IS 9
AR 1252
DI 10.3390/nu10091252
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA GY5YI
UT WOS:000448659900125
PM 30200631
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Robinson, LJ
   Law, JM
   Symonds, ME
   Budge, H
AF Robinson, Lindsay J.
   Law, James M.
   Symonds, Michael E.
   Budge, Helen
TI Brown adipose tissue activation as measured by infrared thermography by
   mild anticipatory psychological stress in lean healthy females
SO EXPERIMENTAL PHYSIOLOGY
LA English
DT Article
ID UNCOUPLING PROTEIN-1; ADULT HUMANS; SUPRACLAVICULAR REGION;
   ENERGY-EXPENDITURE; COLD-EXPOSURE; THERMOGENESIS; FAT; HYPERTHERMIA;
   TEMPERATURE; ADIPOCYTES
AB New Findings
   What is the central question of this study? Does psychological stress, which is known to promote cortisol secretion, simultaneously activate brown adipose tissue function in healthy adult females?
   What is the main finding and its importance? One explanation for the pronounced differences in brown adipose tissue function between individuals lies in their responsiveness to psychological stress and, as such, should be taken into account when examining its in vivo stimulation.
   Brown adipose tissue (BAT) has been implicated in the pathogenesis of obesity, type2 diabetes and the metabolic syndrome and is a potential therapeutic target. Brown adipose tissue can have a significant impact on energy balance and glucose homeostasis through the action of uncoupling protein1, dissipating chemical energy as heat following neuroendocrine stimulation. We hypothesized that psychological stress, which is known to promote cortisol secretion, would simultaneously activate BAT at thermoneutrality. Brown adipose tissue activity was measured using infrared thermography to determine changes in the temperature of the skin overlying supraclavicular BAT (T-SCR). A mild psychological stress was induced in five healthy, lean, female, Caucasian volunteers using a short mental arithmetic (MA) test. The T-SCR was compared with a repeated assessment, in which the MA test was replaced with a period of relaxation. Although MA did not elicit an acute stress response, anticipation of MA testing led to an increase in salivary cortisol, indicative of an anticipatory stress response, that was associated with a trend towards higher absolute and relative T-SCR. A positive correlation between T-SCR and cortisol was found during the anticipatory phase, a relationship that was enhanced by increased cortisol linked to MA. Our findings suggest that subtle changes in the level of psychological stress can stimulate BAT, findings that may account for the high variability and inconsistency in reported BAT prevalence and activity measured by other modalities. Consistent assessment of this uniquely metabolic tissue is fundamental to the discovery of potential therapeutic strategies against metabolic disease.
C1 [Robinson, Lindsay J.; Law, James M.; Symonds, Michael E.; Budge, Helen] Univ Nottingham, Univ Nottingham Hosp, Sch Med, Div Child Hlth Obstet & Gynaecol,Early Life Res U, Nottingham NG7 2UH, England.
C3 University of Nottingham
RP Symonds, ME (corresponding author), Univ Nottingham, Univ Nottingham Hosp, Sch Med, Div Child Hlth Obstet & Gynaecol,Early Life Res U, Nottingham NG7 2UH, England.
EM michael.symonds@nottingham.ac.uk
RI Law, James/M-8888-2018
OI Law, James/0000-0002-4923-3193; Symonds, Michael/0000-0001-9649-8963
FU University of Nottingham; Nottingham University Hospitals Charity
FX This work was supported by the University of Nottingham and the
   Nottingham University Hospitals Charity.
CR Barclay JL, 2015, J ENDOCRINOL, V224, P139, DOI 10.1530/JOE-14-0538
   BRILLON DJ, 1995, AM J PHYSIOL-ENDOC M, V268, pE501, DOI 10.1152/ajpendo.1995.268.3.E501
   Cannon B, 2004, PHYSIOL REV, V84, P277, DOI 10.1152/physrev.00015.2003
   Carey AL, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0091997
   Celi FS, 2015, TRENDS ENDOCRIN MET, V26, P238, DOI 10.1016/j.tem.2015.03.003
   Cypess AM, 2015, CELL METAB, V21, P33, DOI 10.1016/j.cmet.2014.12.009
   Cypess AM, 2014, CELL METAB, V20, P408, DOI 10.1016/j.cmet.2014.07.025
   Cypess AM, 2009, NEW ENGL J MED, V360, P1509, DOI 10.1056/NEJMoa0810780
   Fazeli PK, 2015, J CLIN INVEST, V125, P4601, DOI 10.1172/JCI83349
   Feldmann HM, 2009, CELL METAB, V9, P203, DOI 10.1016/j.cmet.2008.12.014
   Gelfand MJ, 2005, PEDIATR RADIOL, V35, P984, DOI 10.1007/s00247-005-1505-8
   Greaney JL, 2015, J PHYSIOL-LONDON, V593, P2199, DOI 10.1113/JP270062
   Hardy JD, 1938, J CLIN INVEST, V17, P771, DOI 10.1172/JCI101007
   Hwang JJ, 2015, METABOLISM, V64, P747, DOI 10.1016/j.metabol.2015.03.001
   Jacobsson H, 2005, EUR J NUCL MED MOL I, V32, P1130, DOI 10.1007/s00259-005-1851-7
   Jang C, 2014, PHYSIOL REP, V2, DOI 10.14814/phy2.12167
   Jespersen NZ, 2013, CELL METAB, V17, P798, DOI 10.1016/j.cmet.2013.04.011
   Kataoka N, 2014, CELL METAB, V20, P346, DOI 10.1016/j.cmet.2014.05.018
   Kirschbaum C, 1997, J CLIN ENDOCR METAB, V82, P1101, DOI 10.1210/jc.82.4.1101
   Kwon MM, 2015, CELL REP, V13, P1521, DOI 10.1016/j.celrep.2015.10.021
   Lee P, 2011, DIABETES OBES METAB, V13, P92, DOI 10.1111/j.1463-1326.2010.01318.x
   Lichtenbelt WDV, 2009, NEW ENGL J MED, V360, P1500, DOI 10.1056/NEJMoa0808718
   Lkhagvasuren B, 2011, EUR J NEUROSCI, V34, P1442, DOI 10.1111/j.1460-9568.2011.07863.x
   Memon M, 2013, TURK J MED SCI, V43, P913, DOI 10.3906/sag-1208-98
   Mohammed M, 2014, AM J PHYSIOL-REG I, V306, pR394, DOI 10.1152/ajpregu.00475.2013
   Mostyn A, 2003, J ENDOCRINOL, V176, P23, DOI 10.1677/joe.0.1760023
   Nagano G, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0122584
   Nedergaard J, 2010, CELL METAB, V11, P268, DOI 10.1016/j.cmet.2010.03.007
   Ouellet V, 2012, J CLIN INVEST, V122, P545, DOI 10.1172/JCI60433
   Pfannenberg C, 2010, DIABETES, V59, P1789, DOI 10.2337/db10-0004
   Robinson L, 2014, J PEDIATR-US, V164, P318, DOI 10.1016/j.jpeds.2013.10.005
   Sacks HS, 2009, J CLIN ENDOCR METAB, V94, P3611, DOI 10.1210/jc.2009-0571
   Saito M, 2009, DIABETES, V58, P1526, DOI 10.2337/db09-0530
   Salem V, 2016, DIABETES OBES METAB, V18, P72, DOI 10.1111/dom.12585
   Sidossis L, 2015, J CLIN INVEST, V125, P478, DOI 10.1172/JCI78362
   Sidossis LS, 2015, CELL METAB, V22, P219, DOI 10.1016/j.cmet.2015.06.022
   Soumano K, 2000, MOL CELL ENDOCRINOL, V165, P7, DOI 10.1016/S0303-7207(00)00276-8
   STRACK AM, 1995, AM J PHYSIOL-REG I, V268, pR183, DOI 10.1152/ajpregu.1995.268.1.R183
   Svensson PA, 2014, OBESITY, V22, P1830, DOI 10.1002/oby.20765
   Symonds ME, 2012, J PEDIATR-US, V161, P892, DOI 10.1016/j.jpeds.2012.04.056
   Viengchareun S, 2001, AM J PHYSIOL-ENDOC M, V280, pE640, DOI 10.1152/ajpendo.2001.280.4.E640
   Vijgen GHEJ, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017247
   Virtanen KA, 2009, NEW ENGL J MED, V360, P1518, DOI 10.1056/NEJMoa0808949
   Vogel WV, 2012, J NUCL MED TECHNOL, V40, P92, DOI 10.2967/jnmt.111.097964
   Zingaretti MC, 2009, FASEB J, V23, P3113, DOI 10.1096/fj.09-133546
NR 45
TC 36
Z9 40
U1 0
U2 13
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0958-0670
EI 1469-445X
J9 EXP PHYSIOL
JI Exp. Physiol.
PD APR 1
PY 2016
VL 101
IS 4
BP 549
EP 557
DI 10.1113/EP085642
PG 9
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Physiology
GA DI7LF
UT WOS:000373680600012
PM 26855404
OA Bronze
DA 2025-06-11
ER

PT J
AU Limon, VM
   Lee, M
   Gonzalez, B
   Choh, AC
   Czerwinski, SA
AF Limon, Victoria M.
   Lee, Miryoung
   Gonzalez, Brandon
   Choh, Audrey C.
   Czerwinski, Stefan A.
TI The impact of metabolic syndrome on mental health-related quality of
   life and depressive symptoms
SO QUALITY OF LIFE RESEARCH
LA English
DT Article
DE Metabolic syndrome; Depressive symptoms; Mental health; Quality of life
ID ASSOCIATION; QUESTIONNAIRE; PREVALENCE; PHQ-9; MODE; RISK; CARE
AB Purpose Results examining associations between metabolic syndrome (MetS) and depression, as well as on quality of life (QoL), are inconsistent. We aimed to determine whether individuals with MetS had decreased mental health-related QoL (MH-QoL) and higher frequency of depressive symptoms. Methods Data from 1,015 participants from the Fels Longitudinal Study were analyzed (mean age +/- SD: 49.6 +/- 18.7 years, 29.3% MetS, 51% females). MetS was determined using American Heart Association/National Heart, Lung, and Blood Institute criteria. Depressive symptoms (yes vs. no) were assessed with The Patient Health Questionnaire-9 (PHQ-9). MH-QoL (low (<= 42) vs. high) was assessed with The Medical Outcomes 36-Item Short Form Survey (SF-36). Sex- and age-stratified mixed effects logistic regressions were used to examine the longitudinal relationship between MetS and MH-QoL while adjusting for covariates such as age, smoking status, and drinking status. Results In cross-sectional analysis, MetS was significantly associated with elevated depressive symptoms in women (OR 2.14, 95% CI 1.22-3.78, p < 0.01), but not in men. In the longitudinal analysis, MetS was observed to have a protective effect among men in the older age group as it approached significance (OR 0.34, 95% CI 0.11-1.05, p = 0.06). Conclusion MetS was adversely associated with depressive symptoms and poor MH-QoL. Our cross-sectional results suggest that depressive symptoms are higher among women with MetS. Interestingly, our longitudinal results suggest that MH-QoL in men with MetS may improve with age.
C1 [Limon, Victoria M.] Roosevelt Univ, Coll Arts & Sci, 430 S Michigan Ave, Chicago, IL 60605 USA.
   [Lee, Miryoung; Gonzalez, Brandon; Choh, Audrey C.; Czerwinski, Stefan A.] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Brownsville, TX USA.
C3 Roosevelt University; University of Texas System; University of Texas
   Health Science Center Houston
RP Limon, VM (corresponding author), Roosevelt Univ, Coll Arts & Sci, 430 S Michigan Ave, Chicago, IL 60605 USA.
EM vlimon@mail.roosevelt.edu
FU National Institutes of Health [HD012252, DK111201]
FX We extend our thanks to the research participants of the Fels
   Longitudinal Study and to all research assistants and staff. This study
   was supported by grants from the National Institutes of Health: HD012252
   and DK111201.
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Ahn S, 2017, INT J ENV RES PUB HE, V14, DOI 10.3390/ijerph14010016
   Akincigil A, 2017, PSYCHIAT SERV, V68, P660, DOI 10.1176/appi.ps.201600096
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   [Anonymous], 2013, CARDIOVASC PSYCHIAT
   BAECKE JAH, 1982, AM J CLIN NUTR, V36, P936
   Cardenas V, 2017, AM J GERIAT PSYCHIAT, V25, P646, DOI 10.1016/j.jagp.2017.02.017
   Carter JD, 2010, J AFFECT DISORDERS, V124, P202, DOI 10.1016/j.jad.2009.11.011
   Cyrus S.H., 2014, Advances in Psychiatric Treatment, V20, P101, DOI 10.1192/apt.bp.113.011619
   East C, 2010, METAB SYNDR RELAT D, V8, P451, DOI 10.1089/met.2010.0017
   Epstein JF, 2001, PUBLIC OPIN QUART, V65, P529, DOI 10.1086/323577
   Ford ES, 2008, ANN EPIDEMIOL, V18, P165, DOI 10.1016/j.annepidem.2007.10.009
   Gibbons RD, 2010, ANNU REV CLIN PSYCHO, V6, P79, DOI 10.1146/annurev.clinpsy.032408.153550
   Guyot E, 2018, NUTRIENTS, V10, DOI 10.3390/nu10020232
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Jenkinson C, 1999, J PUBLIC HEALTH MED, V21, P372, DOI 10.1093/pubmed/21.4.372
   Kahl KG, 2015, BRAIN BEHAV, V5, DOI 10.1002/brb3.306
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Kulkarni KR, 2006, CLIN LAB MED, V26, P787, DOI 10.1016/j.cll.2006.07.004
   Laudisio A, 2013, EUR J NUTR, V52, P307, DOI 10.1007/s00394-012-0337-1
   Laudisio A, 2009, J GERIATR PSYCH NEUR, V22, P215, DOI 10.1177/0891988709335793
   Leese M, 2008, J CLIN EPIDEMIOL, V61, P588, DOI 10.1016/j.jclinepi.2007.08.004
   Levin-Aspenson HF, 2018, PSYCHOL ASSESSMENT, V30, P287, DOI 10.1037/pas0000474
   Liaw FY, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/586251
   Lins L, 2016, SAGE OPEN MED, V4, DOI 10.1177/2050312116671725
   Liu Y, 2017, J AFFECT DISORDERS, V217, P190, DOI 10.1016/j.jad.2017.04.009
   Manea L, 2012, CAN MED ASSOC J, V184, pE191, DOI 10.1503/cmaj.110829
   Mann JJ, 2016, ARCH SUICIDE RES, V20, P412, DOI 10.1080/13811118.2015.1033504
   Marijnissen RM, 2013, J AFFECT DISORDERS, V151, P1138, DOI 10.1016/j.jad.2013.07.029
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   Okosun IS, 2013, DIABETES METAB SYND, V7, P154, DOI 10.1016/j.dsx.2013.06.007
   Onyewuenyi IC, 2014, PHYSIOL BEHAV, V123, P214, DOI 10.1016/j.physbeh.2013.09.014
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pfizer I, 1999, PHQ 9 PATIENT DEPRES
   Roche A.F., 1992, GROWTH MATURATION BO
   Saboya PP, 2017, ARQ BRAS CARDIOL, V108, P60, DOI 10.5935/abc.20160186
   Saboya PP, 2016, REV LAT-AM ENFERM, V24, DOI 10.1590/1518-8345.1573.2848
   Services S. O. T. U. S. D. O. H. A. H, 2018, HLTH US 2017 SPEC FE
   Shinkov A, 2018, POSTGRAD MED, V130, P251, DOI 10.1080/00325481.2018.1410054
   Simon GE, 2001, WESTERN J MED, V175, P292, DOI 10.1136/ewjm.175.5.292
   Singer D., 2003, APPL LONGITUDINAL DA
   Smithson S, 2017, MED CLIN N AM, V101, P807, DOI 10.1016/j.mcna.2017.03.010
   Soltani M, 2015, ACAD PSYCHIATR, V39, P259, DOI 10.1007/s40596-014-0257-x
   The multiple risk factor intervention trial (MRFIT), 1976, JAMA-J AM MED ASSOC, V235, P825
   Vetter ML, 2011, INT J OBESITY, V35, P1087, DOI 10.1038/ijo.2010.230
   Virtanen M, 2017, J CLIN PSYCHIAT, V78, pE1, DOI 10.4088/JCP.15m10399
   Ware J.E., 2003, SF 36 HLTH SURVEY MA
   Womack VY, 2016, PSYCHOSOM MED, V78, P867, DOI 10.1097/PSY.0000000000000347
   Wott CB, 2010, J HEALTH PSYCHOL, V15, P608, DOI 10.1177/1359105309355339
   Yellow Springs OH, 2019, WIKIPEDIA FREE E
NR 50
TC 20
Z9 22
U1 0
U2 8
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-9343
EI 1573-2649
J9 QUAL LIFE RES
JI Qual. Life Res.
PD AUG
PY 2020
VL 29
IS 8
BP 2063
EP 2072
DI 10.1007/s11136-020-02479-5
EA MAR 2020
PG 10
WC Health Care Sciences & Services; Health Policy & Services; Public,
   Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA MK3BX
UT WOS:000521787500001
PM 32215841
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Roohafza, H
   Heidari, D
   Talaei, M
   Nouri, F
   Khani, A
   Sarrafzadegan, N
   Sadeghi, M
AF Roohafza, Hamidreza
   Heidari, Danesh
   Talaei, Mohammad
   Nouri, Fatemeh
   Khani, Azam
   Sarrafzadegan, Nizal
   Sadeghi, Masoumeh
TI Are different perceived stressors associated with metabolic syndrome: a
   longitudinal cohort study of adults in central Iran
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Article
DE Metabolic syndrome; Psychological stress; Perceived stress;
   Psychological distress
ID OBESITY; SAMPLE; WORK
AB PurposeThe link between metabolic syndrome (MetS) and various stressors has not been thoroughly investigated. We aimed to examine the relationship between MetS and different perceived stressors.MethodsIn this study, we included participants of the Isfahan Cohort study from three counties in central Iran, with data in the 2007 (n = 3178) and 2013 (n = 1693) follow-up stages. We examined the association between distress and perceived stress domains (including job security, job conflicts, personal conflicts, loss and separation, social relations, and health concerns) and MetS.ResultsMetS was identified in 35.8% of participants in the 2007 cohort and 46.2% in the 2013 cohort. In the fully adjusted analysis, the odds ratio (OR) (95%CI) for MetS according to psychological status was 1.65 (1.64-1.65) for psychological distress level, 1.09 (1.01-1.20) for psychological distress score, and 1.21 (1.09-1.42) for total perceived stress score. There was also evidence of association for social relations, personal conflicts, job conflicts, job security, health concern, loss and separation, educational concerns, and sexual life subscales.ConclusionPerceived stressors and some of their subscales were associated with MetS.
C1 [Roohafza, Hamidreza; Khani, Azam; Sarrafzadegan, Nizal] Isfahan Univ Med Sci, Cardiovasc Res Inst, Isfahan Cardiovasc Res Ctr, Esfahan, Iran.
   [Heidari, Danesh] Isfahan Univ Med Sci, Sch Med, Esfahan, Iran.
   [Talaei, Mohammad] Queen Mary Univ London, Inst Populat Hlth Sci, Barts & London Sch Med, London, England.
   [Nouri, Fatemeh] Isfahan Univ Med Sci, Cardiovasc Res Inst, Intervent Cardiol Res Ctr, Esfahan, Iran.
   [Sadeghi, Masoumeh] Isfahan Univ Med Sci, Cardiovasc Res Inst, Cardiac Rehabil Res Ctr, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; University of London; Queen Mary University London; Isfahan
   University of Medical Sciences; Isfahan University of Medical Sciences
RP Sadeghi, M (corresponding author), Isfahan Univ Med Sci, Cardiovasc Res Inst, Cardiac Rehabil Res Ctr, Esfahan, Iran.
EM sadeghimasoumeh@gmail.com
RI Sadeghi, Masoumeh/AAU-8493-2021; Taheri, Majid/V-4415-2019; Nouri,
   Fatemeh/KCY-5479-2024
OI Nouri, Fatemeh/0000-0002-0191-7668; Sadeghi Mahonak,
   Masoumeh/0000-0001-7179-5558
FU We would like to express our special thanks of gratitude to all
   individuals who participated in this study and the ICS staff for their
   kind cooperation. Also, we appreciated the Iranian Budget and Planning
   Organization who funded the baseline of the study [31309304]; Iranian
   Budget and Planning Organization
FX We would like to express our special thanks of gratitude to all
   individuals who participated in this study and the ICS staff for their
   kind cooperation. Also, we appreciated the Iranian Budget and Planning
   Organization who funded the baseline of the study with a grant No.
   31309304.
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Bergmann N, 2014, ENDOCR CONNECT, V3, pR55, DOI 10.1530/EC-14-0031
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   Blanquet M, 2016, FAM PRACT, V33, P17, DOI 10.1093/fampra/cmv086
   Capuron L, 2008, BIOL PSYCHIAT, V64, P896, DOI 10.1016/j.biopsych.2008.05.019
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   Cohen S, 2007, JAMA-J AM MED ASSOC, V298, P1685, DOI 10.1001/jama.298.14.1685
   Departement of noncommunicable disease surveillance, 1999, DEF DIAGN CLASS DIAB
   Edwards EM, 2012, J OCCUP ENVIRON MED, V54, P1447, DOI 10.1097/JOM.0b013e3182783f27
   Garcez A, 2017, HORM METAB RES, V49, P510, DOI 10.1055/s-0043-101822
   Gimeno D, 2010, OCCUP ENVIRON MED, V67, P256, DOI 10.1136/oem.2009.047324
   Goldberg D., 1992, General health questionnaire (GHQ-12)
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Hammen C, 2005, ANNU REV CLIN PSYCHO, V1, P293, DOI 10.1146/annurev.clinpsy.1.102803.143938
   Henriksen RE, 2019, J EPIDEMIOL COMMUN H, V73, P941, DOI 10.1136/jech-2019-212335
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Kobayashi T, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-395
   Kuo WC, 2019, OBES REV, V20, P1651, DOI 10.1111/obr.12915
   Liese AD, 1998, EPIDEMIOL REV, V20, P157, DOI 10.1093/oxfordjournals.epirev.a017978
   Mason C, 2009, OBESITY, V17, P1789, DOI 10.1038/oby.2009.87
   MCNAMARA JR, 1987, CLIN CHIM ACTA, V166, P1, DOI 10.1016/0009-8981(87)90188-4
   Montazeri Ali, 2003, Health Qual Life Outcomes, V1, P66, DOI 10.1186/1477-7525-1-66
   Nouri F, 2018, ARYA ATHEROSCLER, V14, P58, DOI 10.22122/arya.v14i2.1488
   Oliver G, 2000, PSYCHOSOM MED, V62, P853, DOI 10.1097/00006842-200011000-00016
   Pakalska-Korcala A, 2008, KARDIOL POL, V66, P500
   Puustinen PJ, 2011, PSYCHOSOM MED, V73, P158, DOI 10.1097/PSY.0b013e3182037315
   Roohafza H, 2012, INT J ENDOCRINOL, V2012, DOI 10.1155/2012/380902
   Roohafza H, 2011, INT J PUBLIC HEALTH, V56, P441, DOI 10.1007/s00038-011-0232-1
   Sarrafzadegan N, 2011, J HUM HYPERTENS, V25, P545, DOI 10.1038/jhh.2010.99
   Sarrafzadegan N, 2009, B WORLD HEALTH ORGAN, V87, P39, DOI 10.2471/BLT.07.049841
   Suarez EC, 2006, BRAIN BEHAV IMMUN, V20, P331, DOI 10.1016/j.bbi.2005.09.005
   Talaei M, 2013, ARYA ATHEROSCLER, V9, P51
   Tamashiro KLK, 2011, ANN NY ACAD SCI, V1231, P46, DOI 10.1111/j.1749-6632.2011.06134.x
   Tenk J, 2018, PSYCHONEUROENDOCRINO, V95, P63, DOI 10.1016/j.psyneuen.2018.05.014
   Troxel WM, 2005, ARCH INTERN MED, V165, P1022, DOI 10.1001/archinte.165.9.1022
   van Vliet-Ostaptchouk JV, 2014, BMC ENDOCR DISORD, V14, DOI 10.1186/1472-6823-14-9
   Whisman MA, 2010, HEALTH PSYCHOL, V29, P550, DOI 10.1037/a0020760
   Wickramasinghe VP, 2005, ANN HUM BIOL, V32, P60, DOI 10.1080/03014460400027805
   Yoo HL, 2009, J OCCUP ENVIRON MED, V51, P46, DOI 10.1097/JOM.0b013e31817f9e43
NR 42
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD DEC
PY 2023
VL 22
IS 2
BP 1715
EP 1721
DI 10.1007/s40200-023-01304-3
EA SEP 2023
PG 7
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA GP6N6
UT WOS:001074833600002
PM 37975076
OA Green Published
DA 2025-06-11
ER

PT J
AU Ali, AT
   Guidozzi, F
AF Ali, A. T.
   Guidozzi, F.
TI Midlife women's health consequences associated with polycystic ovary
   syndrome
SO CLIMACTERIC
LA English
DT Review
DE Polycystic ovary syndrome; metabolic syndrome; obesity; type 2 diabetes;
   depression; cardiovascular disease; endometrial cancer
ID INTIMA-MEDIA THICKNESS; CORONARY-ARTERY CALCIFICATION; IMPAIRED
   GLUCOSE-TOLERANCE; TYPE-2 DIABETES-MELLITUS; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; BLOOD-PRESSURE; INCREASED
   RISK; YOUNG-WOMEN
AB Polycystic ovary syndrome (PCOS) is one of the most common female endocrinopathies. Its symptoms may appear as early as adolescence and may include irregular menstrual periods, amenorrhea, hirsutism and obesity. Regardless of their phenotypic appearance, women with PCOS are metabolically obese. PCOS is associated with metabolic syndrome, type 2 diabetes, depression, cardiovascular disease and gynecological cancers. The metabolic disorders in obese women with PCOS are invariably due to insulin resistance, while inflammation, oxidative stress and possible interaction with environmental factors are among the features linking women with PCOS alone to metabolic disorders. The current review aims to highlight the relationship between PCOS and midlife women's health complications.
C1 [Ali, A. T.] Stellenbosch Univ, Tygerberg Hosp, NHLS, Dept Chem Pathol, Cape Town, South Africa.
   [Ali, A. T.] Stellenbosch Univ, Fac Med & Hlth Sci, Cape Town, South Africa.
   [Guidozzi, F.] Univ Witwatersrand, Fac Hlth Sci, Dept Obstet & Gynaecol, Johannesburg, South Africa.
C3 Tygerberg Hospital; Stellenbosch University; Stellenbosch University;
   University of Witwatersrand
RP Ali, AT (corresponding author), Tygerberg Hosp, Dept Pathol, POB 19113, ZA-7505 Cape Town, South Africa.; Ali, AT (corresponding author), Stellenbosch Med Sch, POB 19113, ZA-7505 Cape Town, South Africa.
EM atali@sun.ac.za
OI Ali, Aus/0000-0002-2026-2433
CR Akram T, 2010, GYNECOL ENDOCRINOL, V26, P47, DOI 10.3109/09513590903159565
   Ali Aus Tariq, 2015, Ceska Gynekol, V80, P279
   Allameh Z, 2013, INT J PREVENTIVE MED, V4, P1266
   Anderson SA, 2014, INT J CARDIOL, V176, P486, DOI 10.1016/j.ijcard.2014.06.079
   Aydin M, 2013, EUR REV MED PHARMACO, V17, P2295
   Barry JA, 2014, HUM REPROD UPDATE, V20, P748, DOI 10.1093/humupd/dmu012
   Bodmer M, 2011, GYNECOL ONCOL, V123, P200, DOI 10.1016/j.ygyno.2011.06.038
   Boorsma W, 2008, OBESITY, V16, P2696, DOI 10.1038/oby.2008.433
   Brinton LA, 2010, FERTIL STERIL, V94, P1787, DOI 10.1016/j.fertnstert.2009.10.012
   Calderon-Margalit R, 2014, ARTERIOSCL THROM VAS, V34, P2688, DOI 10.1161/ATVBAHA.114.304136
   Carmina E, 2007, J CLIN ENDOCR METAB, V92, P2500, DOI 10.1210/jc.2006-2725
   Cascella T, 2008, HUM REPROD, V23, P153, DOI 10.1093/humrep/dem356
   Cassar S, 2015, CLIN ENDOCRINOL, V83, P50, DOI 10.1111/cen.12619
   Chen MJ, 2007, HYPERTENSION, V49, P1442, DOI 10.1161/HYPERTENSIONAHA.106.083972
   Cheung LP, 2008, HUM REPROD, V23, P1431, DOI 10.1093/humrep/den090
   Clark AM, 1998, HUM REPROD, V13, P1502, DOI 10.1093/humrep/13.6.1502
   Conway G, 2014, EUR J ENDOCRINOL, V171, pP1, DOI 10.1530/EJE-14-0253
   Csányi G, 2014, INT J MOL SCI, V15, P6002, DOI 10.3390/ijms15046002
   Cussons AJ, 2008, HUM REPROD, V23, P2352, DOI 10.1093/humrep/den263
   Daan NMP, 2014, FERTIL STERIL, V102, DOI 10.1016/j.fertnstert.2014.08.001
   Desai V, 2014, J CLIN DIAGN RES, V8, pCC1, DOI 10.7860/JCDR/2014/8125.4530
   Dokras A, 2005, OBSTET GYNECOL, V106, P131, DOI 10.1097/01.AOG.0000167408.30893.6b
   Dokras A, 2012, STEROIDS, V77, P338, DOI 10.1016/j.steroids.2011.12.008
   Dokras A, 2012, FERTIL STERIL, V97, P225, DOI 10.1016/j.fertnstert.2011.10.022
   Dokras A, 2011, OBSTET GYNECOL, V117, P145, DOI 10.1097/AOG.0b013e318202b0a4
   Dong Z, 2012, EXP CLIN ENDOCR DIAB, V120, P355, DOI 10.1055/s-0032-1311643
   Ehrmann DA, 2004, AM J PHYSIOL-ENDOC M, V287, pE241, DOI 10.1152/ajpendo.00475.2003
   Ehrmann DA, 1999, DIABETES CARE, V22, P141, DOI 10.2337/diacare.22.1.141
   Elting MW, 2001, HUM REPROD, V16, P556, DOI 10.1093/humrep/16.3.556
   Fearnley EJ, 2010, CANCER CAUSE CONTROL, V21, P2303, DOI 10.1007/s10552-010-9658-7
   Franklin BA, 2004, AM J CARDIOL, V94, P162, DOI 10.1016/j.amjcard.2004.03.053
   Fryar Cheryl D, 2012, NCHS Data Brief, P1
   Giudice LC, 2006, BEST PRACT RES CL EN, V20, P235, DOI 10.1016/j.beem.2006.03.005
   Glintborg D, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0680-5
   Gottschau M, 2015, GYNECOL ONCOL, V136, P99, DOI 10.1016/j.ygyno.2014.11.012
   Barcellos CRG, 2013, GYNECOL ENDOCRINOL, V29, P370, DOI 10.3109/09513590.2012.743009
   Hahn S, 2005, EUR J ENDOCRINOL, V153, P853, DOI 10.1530/eje.1.02024
   Haqq L, 2014, ENDOCR CONNECT, V3, P36, DOI 10.1530/EC-14-0010
   Hart R, 2015, J CLIN ENDOCR METAB, V100, P911, DOI 10.1210/jc.2014-3886
   Hillman JK, 2014, FERTIL STERIL, V101, P530, DOI 10.1016/j.fertnstert.2013.10.055
   Iftikhar S, 2012, NETH J MED, V70, P74
   Karabulut A, 2012, GYNECOL ENDOCRINOL, V28, P111, DOI 10.3109/09513590.2011.589929
   Kaya C, 2010, FERTIL STERIL, V93, P1200, DOI 10.1016/j.fertnstert.2008.10.070
   Khot UN, 2003, JAMA-J AM MED ASSOC, V290, P898, DOI 10.1001/jama.290.7.898
   Klaunig JE, 2011, TOXICOL APPL PHARM, V254, P86, DOI 10.1016/j.taap.2009.11.028
   Kollias A, 2013, OBESITY, V21, P1013, DOI 10.1002/oby.20194
   Kuchenbecker WKH, 2011, HUM REPROD, V26, P2505, DOI 10.1093/humrep/der229
   Lanzo E, 2015, PEDIATR ANN, V44, pE223, DOI 10.3928/00904481-20150910-10
   Lee CD, 2007, AM J CLIN NUTR, V86, P48, DOI 10.1093/ajcn/86.1.48
   Legro RS, 2005, J CLIN ENDOCR METAB, V90, P3236, DOI 10.1210/jc.2004-1843
   Legro RS, 1999, J CLIN ENDOCR METAB, V84, P165, DOI 10.1210/jc.84.1.165
   Leite A, 2012, ACTA PAEDIATR, V101, pE115, DOI 10.1111/j.1651-2227.2011.02503.x
   Luque-Ramírez M, 2007, J CLIN ENDOCR METAB, V92, P2141, DOI 10.1210/jc.2007-0190
   Mani H, 2013, CLIN ENDOCRINOL, V78, P926, DOI 10.1111/cen.12068
   Marsh KA, 2010, AM J CLIN NUTR, V92, P83, DOI 10.3945/ajcn.2010.29261
   McCook JG, 2015, J BEHAV HEALTH SER R, V42, P383, DOI 10.1007/s11414-013-9382-7
   Meun C, 2018, J CLIN ENDOCR METAB, V103, P1622, DOI 10.1210/jc.2017-02421
   Meyer ML, 2012, HUM REPROD UPDATE, V18, P112, DOI 10.1093/humupd/dmr046
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Moran LJ, 2012, REPROD BIOMED ONLINE, V25, P500, DOI 10.1016/j.rbmo.2012.07.013
   Moran LJ, 2010, HUM REPROD UPDATE, V16, P347, DOI 10.1093/humupd/dmq001
   Moran LJ, 2009, FERTIL STERIL, V92, P1966, DOI 10.1016/j.fertnstert.2008.09.018
   Nieuwenhuis-Ruifrok AE, 2009, HUM REPROD UPDATE, V15, P57, DOI 10.1093/humupd/dmn043
   Nouwen A, 2010, DIABETOLOGIA, V53, P2480, DOI 10.1007/s00125-010-1874-x
   Nybacka Å, 2011, FERTIL STERIL, V96, P1508, DOI 10.1016/j.fertnstert.2011.09.006
   Ollila MME, 2017, HUM REPROD, V32, P423, DOI 10.1093/humrep/dew329
   Oren A, 2003, INT J OBESITY, V27, P1383, DOI 10.1038/sj.ijo.0802404
   Orio F, 2005, J CLIN ENDOCR METAB, V90, P2, DOI 10.1210/jc.2004-0628
   Panidis D, 2013, CLIN ENDOCRINOL, V78, P586, DOI 10.1111/cen.12008
   Peppa M, 2013, OBESITY, V21, P1807, DOI 10.1002/oby.20227
   Pierpoint T, 1998, J CLIN EPIDEMIOL, V51, P581, DOI 10.1016/S0895-4356(98)00035-3
   Reis JP, 2013, JAMA-J AM MED ASSOC, V310, P280, DOI 10.1001/jama.2013.7833
   Sarris J, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/1471-244X-14-107
   Schmidt J, 2011, J CLIN ENDOCR METAB, V96, P3794, DOI 10.1210/jc.2011-1677
   Shen CC, 2015, ONCOLOGIST, V20, P45, DOI 10.1634/theoncologist.2014-0311
   Shen Y, 2013, BIOMED ENVIRON SCI, V26, P531, DOI 10.3967/0895-3988.2013.07.003
   Shi L, 2011, BRIT J NUTR, V105, P747, DOI 10.1017/S0007114510004307
   Sirmans SM, 2014, J INVEST MED, V62, P868, DOI 10.1097/01.JIM.0000446834.90599.5d
   Tola EN, 2017, EUR J OBSTET GYN R B, V214, P168, DOI 10.1016/j.ejogrb.2017.05.014
   Ullah A, 2016, SAUDI PHARM J, V24, P547, DOI 10.1016/j.jsps.2015.03.013
   Ün B, 2016, EUR J OBSTET GYN R B, V204, P16, DOI 10.1016/j.ejogrb.2016.06.022
   Van Gaal LF, 2006, NATURE, V444, P875, DOI 10.1038/nature05487
   Vause TDR, 2010, INT J GYNECOL OBSTET, V111, P95, DOI 10.1016/j.ijgo.2010.07.001
   Vrbikova J, 2009, GYNECOL OBSTET INVES, V68, P186, DOI 10.1159/000232574
   Wild Sarah, 2000, Hum Fertil (Camb), V3, P101, DOI 10.1080/1464727002000198781
   Zadhoush F, 2015, J RES MED SCI, V20, P763, DOI 10.4103/1735-1995.168383
   Zhao LQ, 2016, ONCOTARGET, V7, P33715, DOI 10.18632/oncotarget.9553
   Zhou YQ, 2017, GYNECOL ENDOCRINOL, V33, P904, DOI 10.1080/09513590.2017.1347779
   Zuo T, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/8589318
NR 89
TC 4
Z9 4
U1 0
U2 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1369-7137
EI 1473-0804
J9 CLIMACTERIC
JI Climacteric
PD MAR 3
PY 2020
VL 23
IS 2
BP 116
EP 122
DI 10.1080/13697137.2019.1679111
EA OCT 2019
PG 7
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA KI1HZ
UT WOS:000492886200001
PM 31657237
DA 2025-06-11
ER

PT J
AU Schwartz, JA
   Savolainen, J
   Granger, DA
   Calvi, JL
AF Schwartz, Joseph A.
   Savolainen, Jukka
   Granger, Douglas A.
   Calvi, Jessica L.
TI Is Crime Bad for Your Health? The Link Between Delinquent Offending and
   Cardiometabolic Risk
SO CRIME & DELINQUENCY
LA English
DT Article
DE stress; cardiometabolic risk; health; delinquency
ID GENERAL STRAIN THEORY; PERCEIVED DISCRIMINATION; BIOLOGICAL STRESS;
   OXIDATIVE STRESS; ALLOSTATIC LOAD; YOUNG-ADULTS; ADOLESCENTS;
   VICTIMIZATION; EXPERIENCES; FOUNDATION
AB Specific sources of psychophysiological dysfunction have been identified as a primary mechanism of the association between stress and health, wherein chronic and prolonged exposure to stressors results in downstream negative consequences of stress-linked dysregulation that increase the likelihood of chronic health problems. Factors pertinent to criminological inquiry have been previously identified as sources of physiological dysfunction, but the extent to which offending over the life course operates in a similar manner has yet to be examined. The current study examines the longitudinal association between delinquency and physiological dysfunction in cardiovascular and metabolic functioning (i.e., cardiometabolic risk). The results of longitudinal structural equation models revealed that greater levels of delinquency are associated with higher levels of cardiometabolic risk.
C1 [Schwartz, Joseph A.] Univ Nebraska, Sch Criminol & Criminal Justice, 6001 Dodge St,218 CPACS, Omaha, NE 68182 USA.
   [Savolainen, Jukka] Wayne State Univ, Sociol & Criminol, Detroit, MI USA.
   [Granger, Douglas A.] Johns Hopkins Univ, Baltimore, MD USA.
   [Granger, Douglas A.] Univ Calif Irvine, Inst Interdisciplinary Salivary Biosci Res, Irvine, CA USA.
   [Granger, Douglas A.] Univ Calif Irvine, Beall Appl Innovat, Irvine, CA USA.
   [Granger, Douglas A.] Univ Nebraska, Lincoln, NE USA.
   [Calvi, Jessica L.] Univ Nebraska, Salivary Biosci Lab, Lincoln, NE USA.
C3 University of Nebraska System; Wayne State University; Johns Hopkins
   University; University of California System; University of California
   Irvine; University of California System; University of California
   Irvine; University of Nebraska System; University of Nebraska Lincoln;
   University of Nebraska System; University of Nebraska Lincoln
RP Schwartz, JA (corresponding author), Univ Nebraska, Sch Criminol & Criminal Justice, 6001 Dodge St,218 CPACS, Omaha, NE 68182 USA.
EM jaschwartz@unomaha.edu
OI Schwartz, Joseph/0000-0001-5777-0573
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development [P01-HD31921]
FX This research uses data from the National Longitudinal Study of
   Adolescent to Adult Health (Add Health), a program project directed by
   Kathleen Mullan Harris and designed by J. Richard Udry, Peter S.
   Bearman, and Kathleen Mullan Harris at the University of North Carolina
   at Chapel Hill, and funded by grant P01-HD31921 from the Eunice Kennedy
   Shriver National Institute of Child Health and Human Development, with
   cooperative funding from 23 other federal agencies and foundations.
   Special acknowledgment is due Ronald R. Rindfuss and Barbara Entwisle
   for assistance in the original design. Information on how to obtain the
   Add Health data files is available on the Add Health website
   (http://www.cpc.unc.edu/addhealth).No direct support was received from
   grant P01-HD31921 for this analysis.
CR Agnew R, 2001, J RES CRIME DELINQ, V38, P319, DOI 10.1177/0022427801038004001
   AGNEW R, 1992, CRIMINOLOGY, V30, P47, DOI 10.1111/j.1745-9125.1992.tb01093.x
   Agnew R, 2002, CRIMINOLOGY, V40, P43, DOI 10.1111/j.1745-9125.2002.tb00949.x
   Armstrong T, 2012, CLIN PSYCHOL REV, V32, P704, DOI 10.1016/j.cpr.2012.09.004
   Brezina T, 1996, CRIMINOLOGY, V34, P39, DOI 10.1111/j.1745-9125.1996.tb01194.x
   Brody GH, 2014, CHILD DEV, V85, P989, DOI 10.1111/cdev.12213
   BYRNE BM, 1989, PSYCHOL BULL, V105, P456, DOI 10.1037/0033-2909.105.3.456
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Del Giudice M, 2011, NEUROSCI BIOBEHAV R, V35, P1562, DOI 10.1016/j.neubiorev.2010.11.007
   Dhalla NS, 2000, J HYPERTENS, V18, P655, DOI 10.1097/00004872-200018060-00002
   Ellis BJ, 2012, DEV PSYCHOL, V48, P598, DOI 10.1037/a0026220
   Farrington D.P., 1995, CRIM BEHAV MENT HEAL, V5, P261, DOI DOI 10.1002/CBM.1995.5.4.261
   Fazel S, 2011, LANCET, V377, P956, DOI 10.1016/S0140-6736(10)61053-7
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gerber M, 2009, SCAND J PUBLIC HEALT, V37, P801, DOI 10.1177/1403494809350522
   Harris K. M., 2009, NATL LONGITUDINAL ST, DOI [10.3886/ICPSR27021.v9, DOI 10.3886/ICPSR27021.V9]
   Hatzenbuehler ML, 2014, HEALTH PSYCHOL, V33, P1185, DOI 10.1037/hea0000126
   Hellhammer DH, 2009, PSYCHONEUROENDOCRINO, V34, P163, DOI 10.1016/j.psyneuen.2008.10.026
   Himmelstein MS, 2019, PSYCHOL MEN MASCULIN, V20, P491, DOI 10.1037/men0000187
   Hu LT, 1999, STRUCT EQU MODELING, V6, P1, DOI 10.1080/10705519909540118
   Jacobs BA, 2006, CAMB STUD CRIMINOL, P1, DOI 10.1017/CBO9780511816055
   Jirapramukpitak T, 2011, SOC PSYCH PSYCH EPID, V46, P825, DOI 10.1007/s00127-010-0252-9
   Kivivuori J, 2016, ACTA SOCIOL, V59, P69, DOI 10.1177/0001699315607969
   Kliewer W, 2016, J YOUTH ADOLESCENCE, V45, P1812, DOI 10.1007/s10964-015-0398-6
   LAURITSEN JL, 1991, CRIMINOLOGY, V29, P265, DOI 10.1111/j.1745-9125.1991.tb01067.x
   Link BG, 2001, PSYCHIATR SERV, V52, P1621, DOI 10.1176/appi.ps.52.12.1621
   Lucas T, 2017, PSYCHOSOM MED, V79, P293, DOI 10.1097/PSY.0000000000000406
   Massoglia M, 2008, J HEALTH SOC BEHAV, V49, P56, DOI 10.1177/002214650804900105
   MATSUEDA RL, 1992, AM J SOCIOL, V97, P1577, DOI 10.1086/229940
   McEwen BS, 1999, ANN NY ACAD SCI, V896, P30, DOI 10.1111/j.1749-6632.1999.tb08103.x
   McEwen BS, 2003, HORM BEHAV, V43, P2, DOI 10.1016/S0018-506X(02)00024-7
   McEwen BS, 1998, ANN NY ACAD SCI, V840, P33, DOI 10.1111/j.1749-6632.1998.tb09546.x
   Moffitt TE, 2011, P NATL ACAD SCI USA, V108, P2693, DOI 10.1073/pnas.1010076108
   Morrison R, 2005, J CLIN PSYCHOL, V61, P447, DOI 10.1002/jclp.20021
   Muthen L.K., 2017, MPLUS USERS GUIDE, VEighth, DOI [DOI 10.1111/J.1600-0447.2011.01711.X, 10.1111/j.1600-0447.2011.01711.x]
   Nolen-Hoeksema S, 2008, PERSPECT PSYCHOL SCI, V3, P400, DOI 10.1111/j.1745-6924.2008.00088.x
   Pager D, 2003, AM J SOCIOL, V108, P937, DOI 10.1086/374403
   Robinson F, 2000, HEALTH RISK SOC, V2, P253, DOI 10.1080/713670168
   Room R, 2005, LANCET, V365, P519, DOI 10.1016/S0140-6736(05)70276-2
   Rossman B. B., 2001, J EMOTIONAL ABUSE, V2, P31, DOI DOI 10.1177/0886260516629386
   Sapolsky RobertM., 2018, BEHAVE BIOL HUMANS O
   Satorra A, 2010, PSYCHOMETRIKA, V75, P243, DOI 10.1007/S11336-009-9135-Y
   Saydah S, 2013, PEDIATRICS, V131, pE679, DOI 10.1542/peds.2012-2583
   Schwartz JA, 2019, CHILD ABUSE NEGLECT, V88, P420, DOI 10.1016/j.chiabu.2018.12.022
   Spohn Ryan., 2011, Criminal Justice Review, V36, P332, DOI DOI 10.1177/0734016811402495
   Sullivan CJ, 2014, J QUANT CRIMINOL, V30, P709, DOI 10.1007/s10940-014-9220-y
   SYKES GM, 1957, AM SOCIOL REV, V22, P664, DOI 10.2307/2089195
   Theall KP, 2017, JAMA PEDIATR, V171, P53, DOI 10.1001/jamapediatrics.2016.2321
   Vazsonyi AT, 2006, CRIM JUSTICE BEHAV, V33, P511, DOI 10.1177/0093854806287318
   Wassink J, 2017, J IMMIGR MINOR HEALT, V19, P1018, DOI 10.1007/s10903-016-0495-y
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Wickrama KAS, 2015, J ADOLESCENT HEALTH, V56, P456, DOI 10.1016/j.jadohealth.2014.12.009
   Widom CS, 2015, CHILD ABUSE NEGLECT, V47, P59, DOI 10.1016/j.chiabu.2015.01.016
NR 53
TC 12
Z9 12
U1 0
U2 8
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0011-1287
EI 1552-387X
J9 CRIME DELINQUENCY
JI Crime Delinq.
PD SEP
PY 2020
VL 66
IS 10
SI SI
BP 1347
EP 1368
AR 0011128720903048
DI 10.1177/0011128720903048
EA FEB 2020
PG 22
WC Criminology & Penology
WE Social Science Citation Index (SSCI)
SC Criminology & Penology
GA MM2ET
UT WOS:000513403700001
DA 2025-06-11
ER

PT J
AU Ji, S
   Chen, YJ
   Zhou, YY
   Cao, YT
   Li, X
   Ding, GY
   Tang, F
AF Ji, Shuang
   Chen, Yujiao
   Zhou, Yuying
   Cao, Yiting
   Li, Xiao
   Ding, Guoyong
   Tang, Fang
TI Association between anxiety and metabolic syndrome: An updated
   systematic review and meta-analysis
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE anxiety; metabolic syndrome; cross-sectional study; cohort study;
   meta-analysis
ID RISK-FACTORS; DEPRESSION; HEALTH; PREVALENCE; SYMPTOMS; DISEASE;
   DISORDERS; QUALITY; OBESITY; IMPACT
AB ObjectivePrevious studies have demonstrated an association between anxiety and metabolic syndrome (MetS). However, the association is still controversial. This updated meta-analysis aimed to reanalyze the association between anxiety and MetS. MethodsWe comprehensively searched PubMed, Embase and Web of Science for all related studies published before January 23, 2023. Observational studies that informed effect size with 95% confidence interval (CI) for the association between anxiety and MetS were included. According to heterogeneity between studies, fixed or random effects models were applied to calculate the pooled effect size. Publication bias was examined by funnel plots. ResultsThe research included 24 cross-sectional studies: 20 studies used MetS as the dependent variable with a pooled OR of 1.07 (95% CI: 1.01-1.13) and four studies used anxiety as the dependent variable with a pooled OR of 1.14 (95% CI: 1.07-1.23). Three cohort studies were found: two studies detected the association of baseline anxiety with the risk of MetS, one of the studies demonstrated a significant association, but a similar result was not found in another study; one study showed no significant association between baseline MetS and the risk of anxiety. ConclusionCross-sectional studies indicated an association between anxiety and MetS. The results from cohort studies are still inconsistent and limited. More large-scale prospective studies are needed to further reveal the causal relationship of anxiety with MetS.
C1 [Ji, Shuang; Chen, Yujiao; Zhou, Yuying; Cao, Yiting; Tang, Fang] Weifang Med Univ, Shandong Prov Qianfoshan Hosp, Dept Neurol, Jinan, Peoples R China.
   [Ji, Shuang; Chen, Yujiao; Zhou, Yuying; Cao, Yiting; Tang, Fang] Shandong Inst Neuroimmunol, Jinan, Peoples R China.
   [Li, Xiao] Shandong First Med Univ & Shandong Prov Qianfoshan, Dept Clin Pharm, Affiliated Hosp 1, Jinan, Peoples R China.
   [Li, Xiao] Shandong Univ, Shandong Prov Qianfoshan Hosp, Dept Clin Pharm, Jinan, Peoples R China.
   [Ding, Guoyong] Shandong First Med Univ & Shandong Acad Med Sci, Sch Publ Hlth, Jinan, Peoples R China.
   [Tang, Fang] Shandong First Med Univ, Ctr Big Data Res Hlth & Med, Affiliated Hosp 1, Jinan, Peoples R China.
   [Tang, Fang] Shandong Univ, Shandong Prov Qianfoshan Hosp, Cheeloo Coll Med, Jinan, Peoples R China.
C3 Shandong Second Medical University; Shandong First Medical University &
   Shandong Academy of Medical Sciences; Shandong First Medical University
   & Shandong Academy of Medical Sciences; Shandong University; Shandong
   First Medical University & Shandong Academy of Medical Sciences;
   Shandong First Medical University & Shandong Academy of Medical
   Sciences; Shandong First Medical University & Shandong Academy of
   Medical Sciences; Shandong University
RP Tang, F (corresponding author), Weifang Med Univ, Shandong Prov Qianfoshan Hosp, Dept Neurol, Jinan, Peoples R China.; Tang, F (corresponding author), Shandong Inst Neuroimmunol, Jinan, Peoples R China.; Ding, GY (corresponding author), Shandong First Med Univ & Shandong Acad Med Sci, Sch Publ Hlth, Jinan, Peoples R China.; Tang, F (corresponding author), Shandong First Med Univ, Ctr Big Data Res Hlth & Med, Affiliated Hosp 1, Jinan, Peoples R China.; Tang, F (corresponding author), Shandong Univ, Shandong Prov Qianfoshan Hosp, Cheeloo Coll Med, Jinan, Peoples R China.
EM dgy-153@163.com; tangfangsdu@gmail.com
RI YiTing, Cao/HMO-6039-2023
FU National Natural Science Foundation of China [71804093]; Academic
   Promotion Programme of Shandong First Medical University [2019LJ005,
   2019QL013]; Academic Promotion Programme of School of Public Health,
   Shandong First Medical University [GW202218]
FX This study was supported by the National Natural Science Foundation of
   China (71804093), Academic Promotion Programme of Shandong First Medical
   University (2019LJ005 and 2019QL013), and Academic Promotion Programme
   of School of Public Health, Shandong First Medical University
   (GW202218).
CR Akbari H, 2017, J RES MED SCI, V22, DOI 10.4103/jrms.JRMS_288_16
   Albert U, 2013, GEN HOSP PSYCHIAT, V35, P154, DOI 10.1016/j.genhosppsych.2012.10.004
   Alonso J, 2018, DEPRESS ANXIETY, V35, P195, DOI 10.1002/da.22711
   Anacker C, 2016, BIOL PSYCHIAT, V79, P840, DOI 10.1016/j.biopsych.2015.08.009
   Bagherniya M, 2017, DIABETES METAB SYND, V11, pS561, DOI 10.1016/j.dsx.2017.04.005
   Balkau B, 2010, DIABETES CARE, V33, P1044, DOI 10.2337/dc09-1901
   Batelaan NM, 2016, BRIT J PSYCHIAT, V208, P223, DOI 10.1192/bjp.bp.114.156554
   Berto LF, 2022, J ACAD CONSULT-LIAIS, V63, P529, DOI 10.1016/j.jaclp.2022.06.001
   Birdsill AC, 2013, OBESITY, V21, P1313, DOI 10.1002/oby.20170
   Butnoriene J, 2018, BMC PSYCHIATRY, V18, DOI 10.1186/s12888-017-1576-8
   Butnoriene J, 2014, PSYCHONEUROENDOCRINO, V40, P269, DOI 10.1016/j.psyneuen.2013.11.002
   Byrd JB, 2014, CURR HYPERTENS REP, V16, DOI 10.1007/s11906-014-0486-0
   Carroll D, 2009, BIOL PSYCHIAT, V66, P91, DOI 10.1016/j.biopsych.2009.02.020
   Chang RS, 2022, APPETITE, V168, DOI 10.1016/j.appet.2021.105707
   Cohen BE, 2010, PSYCHIAT RES, V175, P133, DOI 10.1016/j.psychres.2009.02.004
   Craske MG, 2016, LANCET, V388, P3048, DOI 10.1016/S0140-6736(16)30381-6
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Dortland AKBV, 2010, ACTA PSYCHIAT SCAND, V122, P30, DOI 10.1111/j.1600-0447.2010.01565.x
   Du XY, 2018, INT J SURG, V59, P67, DOI 10.1016/j.ijsu.2018.09.017
   Eckel RH, 2010, LANCET, V375, P181, DOI 10.1016/S0140-6736(09)61794-3
   Espeland MA, 2013, DIABETES CARE, V36, P90, DOI 10.2337/dc12-0555
   Fiksdal A, 2019, PSYCHONEUROENDOCRINO, V102, P44, DOI 10.1016/j.psyneuen.2018.11.035
   Ford ES, 2008, DIABETES CARE, V31, P1898, DOI 10.2337/dc08-0423
   Gaines J, 2018, SLEEP MED REV, V42, P211, DOI 10.1016/j.smrv.2018.08.009
   Glaus J, 2013, ACTA PSYCHIAT SCAND, V128, P282, DOI 10.1111/acps.12057
   Hahn C., 2015, JAMA NEUROL, V1, P1
   Heraclides A, 2009, DIABETES CARE, V32, P2230, DOI 10.2337/dc09-0132
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Higgins JPT, 2021, Cochrane Handbook for Systematic Reviews of Interventions version 6.2
   Hildrum B, 2009, ACTA PSYCHIAT SCAND, V120, P14, DOI 10.1111/j.1600-0447.2008.01315.x
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Hu JD, 2015, COMPR PSYCHIAT, V61, P78, DOI 10.1016/j.comppsych.2015.05.001
   Jacobson L, 2014, COMPR PHYSIOL, V4, P715, DOI 10.1002/cphy.c130036
   Kahl KG, 2015, BRAIN BEHAV, V5, DOI 10.1002/brb3.306
   Khan KS, 1996, ARCH INTERN MED, V156, P661, DOI 10.1001/archinte.156.6.661
   Ko GTC, 2006, DIABETES RES CLIN PR, V73, P58, DOI 10.1016/j.diabres.2005.11.009
   Koro CE, 2002, BMJ-BRIT MED J, V325, P243, DOI 10.1136/bmj.325.7358.243
   Kuo WC, 2019, OBES REV, V20, P1651, DOI 10.1111/obr.12915
   Lee MK, 2020, DIABETES RES CLIN PR, V165, DOI 10.1016/j.diabres.2020.108237
   Li RC, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-58973-w
   Likhtik E, 2014, NAT NEUROSCI, V17, P106, DOI 10.1038/nn.3582
   Lubas MM, 2021, CANCER EPIDEM BIOMAR, V30, P286, DOI 10.1158/1055-9965.EPI-20-1183
   Luppino FS, 2011, PSYCHOSOM MED, V73, P257, DOI 10.1097/PSY.0b013e31820a59c0
   Macht M, 2000, APPETITE, V35, P65, DOI 10.1006/appe.2000.0325
   Mattei G, 2018, J NERV MENT DIS, V206, P316, DOI 10.1097/NMD.0000000000000807
   Mazzone CM, 2018, MOL PSYCHIATR, V23, P143, DOI 10.1038/mp.2016.218
   Michopoulos V, 2017, NEUROPSYCHOPHARMACOL, V42, P254, DOI 10.1038/npp.2016.146
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Moran TP, 2016, PSYCHOL BULL, V142, P831, DOI 10.1037/bul0000051
   Moreira FP, 2019, BRAZ J PSYCHIAT, V41, P38, DOI 10.1590/1516-4446-2017-2328
   Peltzer K, 2018, IRAN J PSYCHIATRY BE, V12, DOI 10.5812/ijpbs.60829
   Penninx BWJH, 2021, LANCET, V397, P914, DOI 10.1016/S0140-6736(21)00359-7
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Pitman A, 2018, BMJ-BRIT MED J, V361, DOI 10.1136/bmj.k1415
   Räikkönen K, 2007, DIABETES CARE, V30, P872, DOI 10.2337/dc06-1857
   Ressler KJ, 2000, DEPRESS ANXIETY, V12, P2, DOI 10.1002/1520-6394(2000)12:1+<2::AID-DA2>3.3.CO;2-W
   Rice JN, 2018, CURR PSYCHIAT REP, V20, DOI 10.1007/s11920-018-0960-5
   Rioli G, 2019, J NERV MENT DIS, V207, P340, DOI 10.1097/NMD.0000000000000969
   Roest AM, 2010, J AM COLL CARDIOL, V56, P38, DOI 10.1016/j.jacc.2010.03.034
   Roohafza H, 2012, INT J ENDOCRINOL, V2012, DOI 10.1155/2012/380902
   Russell G, 2019, NAT REV ENDOCRINOL, V15, P525, DOI 10.1038/s41574-019-0228-0
   Saha S, 2021, DEPRESS ANXIETY, V38, P286, DOI 10.1002/da.23113
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Skogberg N, 2022, J PSYCHOSOM RES, V159, DOI 10.1016/j.jpsychores.2022.110944
   Strand LB, 2015, DIABETES CARE, V38, P2050, DOI 10.2337/dc15-0137
   Stroup DF, 2000, JAMA-J AM MED ASSOC, V283, P2008, DOI 10.1001/jama.283.15.2008
   Tafet GE, 2020, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.00443
   Takeuchi T, 2009, DIABETES METAB, V35, P32, DOI 10.1016/j.diabet.2008.06.006
   Takeuchi T, 2009, DIABETES-METAB RES, V25, P762, DOI 10.1002/dmrr.1041
   Talbot K, 2012, J CLIN INVEST, V122, P1316, DOI 10.1172/JCI59903
   Tang F, 2017, PSYCHONEUROENDOCRINO, V77, P112, DOI 10.1016/j.psyneuen.2016.11.025
   Tank AW, 2015, COMPR PHYSIOL, V5, P1, DOI 10.1002/cphy.c140007
   Tziallas D, 2012, EUR J CARDIOVASC NUR, V11, P297, DOI 10.1016/j.ejcnurse.2011.02.004
   Tziallas Dimitrios, 2011, BMC Res Notes, V4, P105, DOI 10.1186/1756-0500-4-105
   Vogelzangs N, 2007, J GERONTOL A-BIOL, V62, P563, DOI 10.1093/gerona/62.5.563
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Yao F, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124475
   Zhang X, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.768741
NR 79
TC 8
Z9 8
U1 2
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD FEB 16
PY 2023
VL 14
AR 1118836
DI 10.3389/fpsyt.2023.1118836
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 9M4DQ
UT WOS:000942183000001
PM 36873213
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mohammadi, MA
   Dabagh, AE
   Hassanizadeh, S
   Askari, G
   Bagherniya, M
   Sahebkar, A
AF Mohammadi, Mohammad Amin
   Dabagh, Ali Ebrahimi
   Hassanizadeh, Shirin
   Askari, Gholamreza
   Bagherniya, Mohammad
   Sahebkar, Amirhossein
TI Effects of berry consumption on cardiometabolic risk factors in patients
   with metabolic syndrome: a systematic review and meta-analysis of
   randomised controlled trials
SO INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
LA English
DT Review; Early Access
DE Metabolic syndrome; berry; anthropometric; lipid profile; blood
   pressure; inflammation
ID OXIDATIVE STRESS; CRANBERRY JUICE; DOUBLE-BLIND; ANTIOXIDANT CAPACITY;
   ENDOTHELIAL FUNCTION; ADIPOSE-TISSUE; KAPPA-B; INFLAMMATION; EXPRESSION;
   SUPPLEMENTATION
AB The current study explored the effect of berry consumption on metabolic syndrome (MetS) factors. After full screening, 14 trials were selected for final analysis, involving 327 intervention and 284 control subjects with MetS. Berry consumption significantly increased HDL-C (WMD: 1.771 mg/dL, 95% CI: 1.415-2.128) without affecting LDL-C, TC, TG or leptin levels. BMI, waist circumference, systolic and diastolic BP, TNF-alpha, IL-6, CRP, adiponectin, HbA1C, HOMA-IR, glucose and insulin remained unaffected. The subgroup analysis showed that interventions <12 weeks resulted in a significant increase in HDL-C levels and a significant decrease in serum TG levels. On the other hand, reductions in IL-6 and glucose levels were observed in interventions >12 weeks. It was also shown that CRP and HDL-C improvements were seen only in studies that included more than 50 participants. Berry consumption may improve HDL-C, glucose, IL-6 and CRP, supporting its inclusion in dietary strategies for managing MetS.
C1 [Mohammadi, Mohammad Amin; Hassanizadeh, Shirin] Isfahan Univ Med Sci, Student Res Comm, Esfahan, Iran.
   [Mohammadi, Mohammad Amin; Hassanizadeh, Shirin; Askari, Gholamreza; Bagherniya, Mohammad] Isfahan Univ Med Sci, Nutr & Food Secur Res Ctr, Sch Nutr & Food Sci, Esfahan, Iran.
   [Mohammadi, Mohammad Amin; Hassanizadeh, Shirin; Askari, Gholamreza; Bagherniya, Mohammad] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
   [Dabagh, Ali Ebrahimi] Mashhad Univ Med Sci, Sch Med, Dept Nutr Sci, Mashhad, Iran.
   [Askari, Gholamreza; Bagherniya, Mohammad] Isfahan Univ Med Sci, Anesthesia & Crit Care Res Ctr, Esfahan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Chitkara Univ, Chitkara Coll Pharm, Ctr Res Impact & Outcome, Rajpura, Punjab, India.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Basic Sci Res Inst, Appl Biomed Res Ctr, Mashhad, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Mashhad University of
   Medical Sciences; Isfahan University of Medical Sciences; Mashhad
   University of Medical Sciences; Chitkara University, Punjab; Mashhad
   University of Medical Sciences
RP Bagherniya, M (corresponding author), Isfahan Univ Med Sci, Nutr & Food Secur Res Ctr, Sch Nutr & Food Sci, Esfahan, Iran.; Bagherniya, M (corresponding author), Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
EM bagherniya@yahoo.com; amir_saheb2000@yahoo.com
RI Sahebkar, Amirhossein/B-5124-2018; Askari, Gholamreza/ABE-3527-2020;
   Ebrahimi Dabagh, Ali/GYR-0648-2022
FU Student Research Committee of Isfahan University of Medical Sciences
   [1402242]
FX This study was approved by the Research Ethics Committee of Isfahan
   University of Medical Sciences (IR.MUI.PHANUT. REC.1402.058) and
   supported by the Student Research Committee of Isfahan University of
   Medical Sciences (Grant Number: 1402242).
CR Al Zein M, 2023, BIOCHEM PHARMACOL, V218, DOI 10.1016/j.bcp.2023.115876
   Alfadda AA, 2012, J BIOMED BIOTECHNOL, DOI 10.1155/2012/936486
   Ambroselli D, 2023, NUTRIENTS, V15, DOI 10.3390/nu15030640
   Asgary S, 2013, PEDIATR CARDIOL, V34, P1729, DOI 10.1007/s00246-013-0693-5
   Basu A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11091983
   Basu A, 2011, NUTR RES, V31, P190, DOI 10.1016/j.nutres.2011.02.003
   Basu A, 2010, NUTR RES, V30, P462, DOI 10.1016/j.nutres.2010.06.016
   Blanch N, 2015, NUTR METAB CARDIOVAS, V25, P253, DOI 10.1016/j.numecd.2014.10.001
   Brunton SA, 2020, POSTGRAD MED, V132, P3, DOI 10.1080/00325481.2020.1798099
   Simao TNC, 2013, BRIT J NUTR, V110, P1885, DOI 10.1017/S0007114513001207
   Cornell S, 2020, J CLIN PHARM THER, V45, P17, DOI 10.1111/jcpt.13230
   Cumpston M, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.ED000142
   Curtis PJ, 2019, AM J CLIN NUTR, V109, P1535, DOI 10.1093/ajcn/nqy380
   Dakroub A, 2021, J CELL PHYSIOL, V236, P6282, DOI 10.1002/jcp.30345
   Dakroub A, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9112444
   de Souza MO, 2012, NUTR RES, V32, P976, DOI 10.1016/j.nutres.2012.10.001
   Zanchet MZD, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/9763210
   Del Bo C, 2015, FOOD FUNCT, V6, P2890, DOI 10.1039/c5fo00657k
   Duval S, 2000, BIOMETRICS, V56, P455, DOI 10.1111/j.0006-341X.2000.00455.x
   Egger M., 2022, Systematic reviews in health research: meta-analysis in context
   Espinosa-Moncada J, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111639
   Fardoun MM, 2020, CLIN SCI, V134, P1403, DOI 10.1042/CS20200356
   Fontana L, 2007, DIABETES, V56, P1010, DOI 10.2337/db06-1656
   Galvis-Pérez Y, 2020, BIORESEARCH OPEN ACC, V9, P247, DOI 10.1089/biores.2020.0053
   Grundy SM, 2004, CIRCULATION, V110, P227, DOI 10.1161/01.CIR.0000133317.49796.0E
   Guo Q, 2024, SIGNAL TRANSDUCT TAR, V9, DOI 10.1038/s41392-024-01757-9
   Halliwell B, 2008, ARCH BIOCHEM BIOPHYS, V476, P107, DOI 10.1016/j.abb.2008.01.028
   Higgins JP, 2008, Cochrane Handbook for Systematic Reviews of Interventions, P151, DOI DOI 10.1002/9780470712184.CH7
   Higgins JP., 2003, BMJ, V327, P557, DOI [10.1136/bmj.327.7414.557, DOI 10.1136/BMJ.327.7414.557]
   Hozo SP., 2005, BMC MED RES METHODOL, V5, DOI [10.1186/1471-2288-5-13, DOI 10.1186/1471-2288-5-13]
   Hu MH, 2017, BIOMED PHARMACOTHER, V95, P1147, DOI 10.1016/j.biopha.2017.08.120
   Huang HH, 2016, SCI REP-UK, V6, DOI 10.1038/srep23625
   Joseph SV, 2016, CRIT REV FOOD SCI, V56, P419, DOI 10.1080/10408398.2013.767221
   Kamalakkannan N, 2006, BASIC CLIN PHARMACOL, V98, P97, DOI 10.1111/j.1742-7843.2006.pto_241.x
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Kim H, 2018, FOOD FUNCT, V9, P3097, DOI 10.1039/c8fo00595h
   Kolehmainen M, 2012, MOL NUTR FOOD RES, V56, P1501, DOI 10.1002/mnfr.201200195
   Lafontan M, 2014, DIABETES METAB, V40, P16, DOI 10.1016/j.diabet.2013.08.002
   Lail HL, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020334
   Lee M, 2019, BRIT J NUTR, V122, P723, DOI 10.1017/S000711451900165X
   Li WC, 2024, FRONT PHARMACOL, V15, DOI 10.3389/fphar.2024.1416403
   Liu T, 2017, SIGNAL TRANSDUCT TAR, V2, DOI 10.1038/sigtrans.2017.23
   López J, 2017, J FOOD PROCESS ENG, V40, DOI 10.1111/jfpe.12511
   Maaliki D, 2019, CURR OPIN PHARMACOL, V45, P57, DOI 10.1016/j.coph.2019.04.014
   Makki Kassem, 2013, ISRN Inflamm, V2013, P139239, DOI 10.1155/2013/139239
   Marín-Echeverri C, 2021, CYTA-J FOOD, V19, P238, DOI 10.1080/19476337.2021.1884606
   Marín-Echeverri C, 2018, ANTIOXIDANTS-BASEL, V7, DOI 10.3390/antiox7120185
   Marn-Echeverri C., 2020, J Food Nutr Res, V8, P399, DOI [10.12691/jfnr-8-8-3, DOI 10.12691/JFNR-8-8-3]
   Moris D, 2017, ANN TRANSL MED, V5, DOI 10.21037/atm.2017.06.27
   Nair AR, 2017, FOOD FUNCT, V8, P4118, DOI [10.1039/c7fo00815e, 10.1039/C7FO00815E]
   Noubiap JJ, 2022, DIABETES RES CLIN PR, V188, DOI 10.1016/j.diabres.2022.109924
   Page M. J., 2021, INT J SURG, V88, P105906, DOI [10.1016/j.ijsu.2021.105906, DOI 10.1016/J.IJSU.2021.105906]
   Pap N, 2021, CURR OPIN FOOD SCI, V42, P167, DOI 10.1016/j.cofs.2021.06.003
   Puupponen-Pimiä R, 2013, MOL NUTR FOOD RES, V57, P2258, DOI 10.1002/mnfr.201300280
   Qin Y, 2009, AM J CLIN NUTR, V90, P485, DOI 10.3945/ajcn.2009.27814
   Riordan J., 2022, BioMed, V2, P210, DOI 10.3390/biomed2020019
   Roopchand DE, 2013, PHARMACOL RES, V68, P59, DOI 10.1016/j.phrs.2012.11.008
   Ruel G, 2013, NUTR RES, V33, P41, DOI 10.1016/j.nutres.2012.11.002
   Sahebkar A, 2016, NUTRITION, V32, P1179, DOI 10.1016/j.nut.2016.04.007
   Samad F, 2013, BLOOD, V122, P3415, DOI 10.1182/blood-2013-05-427708
   Rie S, 2007, BIOCHEM PHARMACOL, V74, P1619, DOI 10.1016/j.bcp.2007.08.008
   Slika H, 2022, BIOMED PHARMACOTHER, V146, DOI 10.1016/j.biopha.2021.112442
   Stull AJ, 2015, NUTRIENTS, V7, P4107, DOI 10.3390/nu7064107
   Tabatabaei-Malazy O., 2025, Handb Exp Pharmacol, V287, P123, DOI [10.1007/1642024711, DOI 10.1007/1642024711]
   Tian Y, 2018, PUBLIC HEALTH NUTR, V21, P756, DOI 10.1017/S136898001700310X
   Vendrame S, 2015, NUTR REV, V73, P348, DOI 10.1093/nutrit/nuu066
   Venturi S, 2023, NUTRIENTS, V15, DOI 10.3390/nu15081906
   Wang MJ, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.846591
   Wang XF, 2022, PHARMACEUTICALS-BASE, V15, DOI 10.3390/ph15111329
   Wei SS, 2020, CARDIOVASC TOXICOL, V20, P507, DOI 10.1007/s12012-020-09576-4
   Wilken Mikkel Roulund, 2022, Rev Diabet Stud, V18, P42, DOI 10.1900/RDS.2022.18.42
   Xu AJ, 2020, BIOMED PHARMACOTHER, V130, DOI 10.1016/j.biopha.2020.110525
   Xu GY, 2024, BIOMED PHARMACOTHER, V171, DOI 10.1016/j.biopha.2024.116140
   Xu L, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.747884
   Yang SS, 2020, MOL CELL BIOCHEM, V467, P1, DOI 10.1007/s11010-019-03667-9
   Yaribeygi H, 2020, LIFE SCI, V244, DOI 10.1016/j.lfs.2020.117305
   Zhang YL, 2013, J NUTR BIOCHEM, V24, P638, DOI 10.1016/j.jnutbio.2012.03.008
   Zhang YL, 2011, EUR J PHARMACOL, V670, P325, DOI 10.1016/j.ejphar.2011.08.011
   Zhang Y, 2018, PUBLIC HEALTH NUTR, V21, P1693, DOI 10.1017/S1368980018000381
   Zunino SJ, 2007, J NUTR, V137, P1216, DOI 10.1093/jn/137.5.1216
NR 80
TC 0
Z9 0
U1 0
U2 0
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-7486
EI 1465-3478
J9 INT J FOOD SCI NUTR
JI Int. J. Food Sci. Nutr.
PD 2025 MAY 27
PY 2025
DI 10.1080/09637486.2025.2510358
EA MAY 2025
PG 22
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 3EW2L
UT WOS:001498672600001
PM 40436036
DA 2025-06-11
ER

PT J
AU Daneshzad, E
   Keshavarz, SA
   Qorbani, M
   Larijani, B
   Azadbakht, L
AF Daneshzad, Elnaz
   Keshavarz, Seyed-Ali
   Qorbani, Mostafa
   Larijani, Bagher
   Azadbakht, Leila
TI Dietary total antioxidant capacity and its association with sleep,
   stress, anxiety, and depression score: A cross-sectional study among
   diabetic women
SO CLINICAL NUTRITION ESPEN
LA English
DT Article
DE Dietary total antioxidant capacity; Sleep; Depression; Diabetic
   patients; Women
ID METABOLIC SYNDROME; DOUBLE-BLIND; FATTY-ACIDS; OXIDATIVE STRESS; PRIMARY
   INSOMNIA; QUALITY INDEX; ADULTS; PREVALENCE; MAGNESIUM; DURATION
AB Background: Diabetes as a common chronic disease leads to several serious disabilities and complications. Patients with type 2 diabetes are involved with psychological and sleep disorders which diet can be effective in the management of these problems. The present study aimed to investigate the association of Dietary Total Antioxidant Capacity (DTAC) and sleep, stress, anxiety, and depression among diabetic women.
   Methods: This cross-sectional study conducted on 265 women with type 2 diabetes. A validated food frequency questionnaire was filled to evaluate dietary intakes. We calculated DTAC based on amounts of antioxidant in each dietary item using the ferric reducing ability of plasma (FRAP) and oxygen radical absorbance capacity (ORAC) databases. Pittsburgh Sleep Quality Index was used to assess sleep quality. Moreover, 21 items Depression, Anxiety, and Stress Scale was used to assess mental disorders.
   Results: Subjects in the highest tertile of FRAP and ORAC score compared to those in the lowest tertile of these scores had 94% and 87% lower risk of poor sleep, respectively. The odds of depression were negatively related to the highest tertile of FRAP and ORAC score (OR: 0.21, 95%CI: 0.09-0.50 and OR: 0.21, 95%CI: 0.10-0.48, respectively). Participants with the highest tertile of FRAP compared to those within the lowest tertile of FRAP score had a 59% lower risk of anxiety. The odds of stress were negatively related to the highest tertile of FRAP and ORAC score (OR: 0.10, 95%CI: 0.04-0.23 and OR: 0.13, 95%CI: 0.06-0.29, respectively).
   Conclusion: There is a significant association between DTAC, sleep status and psychological disorders. However, prospective studies in both genders should be conducted to confirm the actual relationship. (C) 2020 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.
C1 [Daneshzad, Elnaz; Azadbakht, Leila] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, POB 1416643931, Tehran, Iran.
   [Keshavarz, Seyed-Ali] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran, Iran.
   [Qorbani, Mostafa] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.
   [Qorbani, Mostafa] Univ Tehran Med Sci, Chron Dis Res Ctr, Tehran, Iran.
   [Qorbani, Mostafa] Univ Tehran Med Sci, Metab Populat Sci Inst, Tehran, Iran.
   [Larijani, Bagher] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
   [Azadbakht, Leila] Univ Tehran Med Sci, Diabet Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Alborz University of Medical Sciences; Tehran University of
   Medical Sciences; Tehran University of Medical Sciences; Tehran
   University of Medical Sciences; Tehran University of Medical Sciences
RP Azadbakht, L (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, POB 1416643931, Tehran, Iran.
EM azadbakhtleila@gmail.com
RI Azadbakht, Leila/N-2801-2018; larijani, Bagher/ABE-3315-2020; keshavarz,
   Seyed/AAD-3261-2019; Qorbani, Mostafa/M-8171-2017; Daneshzad,
   Elnaz/O-3694-2018
OI Daneshzad, Elnaz/0000-0003-1400-8532; Larijani,
   Bagher/0000-0001-5386-7597
FU Tehran University of Medical Sciences and Health Services
   [96-03-161-36923]
FX This study is supported by Tehran University of Medical Sciences and
   Health Services (grant number: 96-03-161-36923). We would like to
   express our thankfulness to Dr. Nasli, secretary of the Diabetes
   Research Center of Tehran University of Medical Sciences, and all staffs
   in this center in Tehran, Iran.
CR Abbasi B, 2012, J RES MED SCI, V17, P1161
   Ainsworth BE, 2000, MED SCI SPORT EXER, V32, pS498, DOI 10.1097/00005768-200009001-00009
   Akbaraly TN, 2009, BRIT J PSYCHIAT, V195, P408, DOI 10.1192/bjp.bp.108.058925
   Akbarzadeh H., 2014, International Journal of Caring Sciences, V7, P930
   [Anonymous], J RELIG HLTH
   [Anonymous], SAUDI J KIDNEY DIS T
   [Anonymous], HUM GENOMICS S1
   [Anonymous], PREDICTORS MODERATOR
   [Anonymous], J REN NUTR OFFL J CO
   [Anonymous], USDA DATABASE FLAVON
   [Anonymous], INT DIABETES FEDERAT
   Ayas NT, 2003, ARCH INTERN MED, V163, P205, DOI 10.1001/archinte.163.2.205
   Azadbakht L, 2009, J NUTR, V139, P335, DOI 10.3945/jn.108.096297
   Bjelakovic G, 2007, JAMA-J AM MED ASSOC, V297, P842, DOI 10.1001/jama.297.8.842
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1016/0165-1781(89)90047-4
   CAO GH, 1993, FREE RADICAL BIO MED, V14, P303, DOI 10.1016/0891-5849(93)90027-R
   Cao YT, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101354
   Carlsen MH, 2010, NUTR J, V9, DOI 10.1186/1475-2891-9-37
   Choi JK, 2011, TOHOKU J EXP MED, V225, P187, DOI 10.1620/tjem.225.187
   Coster S., 2000, Health Technology Assessment, V4, pi
   Golden SH, 2017, PSYCHOSOMATICS, V58, P28, DOI 10.1016/j.psym.2016.08.003
   Halvorsen BL, 2002, J NUTR, V132, P461, DOI 10.1093/jn/132.3.461
   Haytowitz DB., 2010, US DEP AGR
   Jacka FN, 2011, PSYCHOSOM MED, V73, P483, DOI 10.1097/PSY.0b013e318222831a
   Jacka FN, 2010, AM J PSYCHIAT, V167, P305, DOI 10.1176/appi.ajp.2009.09060881
   Ji XP, 2015, NUTRIENTS, V7, P5684, DOI 10.3390/nu7075247
   Karupaiah T., 2018, J RENAL NUTR METABOL, V3, P11, DOI DOI 10.4103/2395-1540.232541
   Knutson KL, 2008, ANN NY ACAD SCI, V1129, P287, DOI 10.1196/annals.1417.033
   Kodydková J, 2009, CLIN BIOCHEM, V42, P1368, DOI 10.1016/j.clinbiochem.2009.06.006
   Leenders M, 2014, EUR J EPIDEMIOL, V29, P639, DOI 10.1007/s10654-014-9945-9
   Luyster FS, 2011, DIABETES EDUCATOR, V37, P347, DOI 10.1177/0145721711400663
   Maes M, 2009, NEUROENDOCRINOL LETT, V30, P715
   Mazloom Zohreh, 2013, Pak J Biol Sci, V16, P1597, DOI 10.3923/pjbs.2013.1597.1600
   Milajerdi A, 2018, COMPLEMENT THER MED, V41, P196, DOI 10.1016/j.ctim.2018.09.023
   Moghaddam JF, 2012, SLEEP BREATH, V16, P79, DOI 10.1007/s11325-010-0478-5
   Mozaffari H, 2018, J AM COLL NUTR, V37, P533, DOI 10.1080/07315724.2018.1441079
   Murakami K, 2008, NUTRITION, V24, P140, DOI 10.1016/j.nut.2007.10.013
   Ng F, 2008, INT J NEUROPSYCHOPH, V11, P851, DOI 10.1017/S1461145707008401
   Ohida T, 2001, SLEEP, V24, P333, DOI 10.1093/sleep/24.3.333
   Ortegon MM, 2004, DIABETES CARE, V27, P901, DOI 10.2337/diacare.27.4.901
   Panagiotakos DB, 2010, J AM COLL NUTR, V29, P586, DOI 10.1080/07315724.2010.10719897
   Prohan M, 2014, REDOX REP, V19, P133, DOI 10.1179/1351000214Y.0000000085
   Rashidkhani B, 2013, PSYCHIAT RES, V210, P115, DOI 10.1016/j.psychres.2013.05.022
   Rondanelli M, 2011, J AM GERIATR SOC, V59, P82, DOI 10.1111/j.1532-5415.2010.03232.x
   Samani S., 2008, J Soc Sci Humanit Shiraz Univ, V26, P65
   Sanchez-Villegas A, 2013, BMC MED, V11, DOI [10.1186/1741-7015-11-3, 10.1186/1741-7015-11-208]
   Sanhueza C, 2013, J HUM NUTR DIET, V26, P56, DOI 10.1111/j.1365-277X.2012.01283.x
   Saraf-Bank S, 2017, EUR J CLIN NUTR, V71, P425, DOI 10.1038/ejcn.2016.173
   Sartorius T, 2012, DIABETES, V61, P1669, DOI 10.2337/db11-1521
   Schmitz G, 2008, PROG LIPID RES, V47, P147, DOI 10.1016/j.plipres.2007.12.004
   Shi Z, 2008, INT J OBESITY, V32, P1835, DOI 10.1038/ijo.2008.191
   Shinkov A, 2018, POSTGRAD MED, V130, P251, DOI 10.1080/00325481.2018.1410054
   Siegmann MJ, 2019, SLEEP MED, V55, P92, DOI 10.1016/j.sleep.2018.12.014
   Slavich GM, 2014, PSYCHOL BULL, V140, P774, DOI 10.1037/a0035302
   Spiegel K, 2004, ANN INTERN MED, V141, P846, DOI 10.7326/0003-4819-141-11-200412070-00008
   SRIDHAR GR, 1994, DIABETES RES CLIN PR, V23, P183, DOI 10.1016/0168-8227(94)90103-1
   Tarleton EK, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0180067
   Tarleton EK, 2015, J AM BOARD FAM MED, V28, P249, DOI 10.3122/jabfm.2015.02.140176
   Toi N, 2019, J CLIN TRANSL ENDOCR, V15, P37, DOI 10.1016/j.jcte.2018.12.006
   Valachovicová M, 2006, EUR J NUTR, V45, P52, DOI 10.1007/s00394-005-0563-x
   Wang X, 2014, BMJ-BRIT MED J, V349, DOI 10.1136/bmj.g4490
   Wolniczak I, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0186379
   Yao W, 2016, SCI REP-UK, V6, DOI 10.1038/srep30659
   Zhang JC, 2017, J NUTR BIOCHEM, V39, P134, DOI 10.1016/j.jnutbio.2016.10.004
   Zhou J, 2016, AM J CLIN NUTR, V103, P766, DOI 10.3945/ajcn.115.124669
NR 65
TC 49
Z9 49
U1 0
U2 16
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2405-4577
J9 CLIN NUTR ESPEN
JI Clin. Nutr. ESPEN
PD JUN
PY 2020
VL 37
BP 187
EP 194
DI 10.1016/j.clnesp.2020.03.002
PG 8
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA LL9AD
UT WOS:000531844200006
PM 32359742
DA 2025-06-11
ER

PT J
AU Moorthy, R
   Dinesh, AJ
   Annamalai, MM
AF Moorthy, Renasre
   Dinesh, A. John
   Annamalai, Melody Munusamy
TI Metabolic Syndrome in Patients with Depressive Disorder: A
   Cross-sectional Study
SO INDIAN JOURNAL OF PSYCHOLOGICAL MEDICINE
LA English
DT Article; Early Access
DE Depression; Metabolic syndrome; Dysthymia; Hamilton Depression Rating
   Scale; Determinants; Prevalence; India
ID 3RD NATIONAL-HEALTH; RISK; METAANALYSIS; PREVALENCE; COMPONENTS;
   MORTALITY; OBESITY; ADULTS
AB Background: Depression not only fosters the development of metabolic syndrome through behavioral, physiological, genetic, and treatment-related factors, but it also doubles the risk of experiencing metabolic syndrome. The objectives were to assess the sociodemographic and clinical profile of patients with depressive disorder, to assess the various metabolic parameters of metabolic syndrome in patients with depressive disorder, and to study the association between the severity of depression and metabolic syndrome. Methods: A cross-sectional study was conducted among patients diagnosed with depression (n = 160) attending the Psychiatry outpatient department of a tertiary healthcare facility in Puducherry. The Hamilton Depression Rating Scale (HAM-D) and modified National Cholesterol Education Program-Adult Treatment Panel-III (NCEP ATP-III) criteria were used to assess the severity of depression and diagnose metabolic syndrome, respectively. Results: The mean age at onset of depression was 31.4 years (+11.3); the duration of depression was 41.2 months (+32.5); and the severity of depression as assessed using the HAM-D was 17.9 (+6.3). The results showed that 27.5% of patients had metabolic syndrome. Factors associated with higher rates of metabolic syndrome included increasing age, female gender (79.5%), being single (25.0%), belonging to upper socioeconomic class (65.9%), non-Hindu religion (20.5%), and urban residence (72.7%) (P < .05). Patients with metabolic syndrome had later onset (36.4 years) and longer duration (51.6 months) of depression, more severe symptoms (18.2), and were more likely to have recurrent depressive disorder or dysthymia (88.6%) (P < .05). Furthermore, the current use of psychotropic medications (59.1%) and obesity (93.2%) were significantly associated with metabolic syndrome (P < .05). Conclusion: This study reveals a high prevalence of metabolic syndrome among patients with depressive disorders linked to factors such as age, gender, marital status, socioeconomic status, religion, and urban residence. Integrated care approaches, including comprehensive screening and targeted interventions, are crucial for improving both mental and metabolic health outcomes.
C1 [Moorthy, Renasre; Annamalai, Melody Munusamy] Vinayaka Missions Res Fdn VMRF DU, Aarupadai Veedu Med Coll, Dept Psychiat, Pondicherry, India.
C3 Vinayaka Mission's Research Foundation; Aarupadai Veedu Medical College
   & Hospital
RP Moorthy, R (corresponding author), Aarupadai Veedu Med Coll, Dept Psychiat, Pondicherry 607402, India.
EM renu.aaru@gmail.com
OI Cowan, Charles/0009-0001-0841-0130
CR Al-Khatib Y, 2022, CUREUS J MED SCIENCE, V14, DOI 10.7759/cureus.22153
   Albert PR, 2015, J PSYCHIATR NEUROSCI, V40, P219, DOI 10.1503/jpn.150205
   Angelico F, 2023, INTERN EMERG MED, V18, P1007, DOI 10.1007/s11739-023-03226-7
   Arvind BA, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-027250
   Blazer DG, 2003, J GERONTOL A-BIOL, V58, P249
   Cameron AJ, 2004, ENDOCRIN METAB CLIN, V33, P351, DOI 10.1016/j.ecl.2004.03.005
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Goldbacher EM, 2007, ANN BEHAV MED, V34, P240, DOI 10.1007/BF02874549
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Hiles SA, 2016, DEPRESS ANXIETY, V33, P754, DOI 10.1002/da.22512
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Kessler RC, 2013, ANNU REV PUBL HEALTH, V34, P119, DOI 10.1146/annurev-publhealth-031912-114409
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Koenig Harold G, 2012, ISRN Psychiatry, V2012, P278730, DOI 10.5402/2012/278730
   Liu QQ, 2020, J PSYCHIATR RES, V126, P134, DOI 10.1016/j.jpsychires.2019.08.002
   Lorant V, 2003, AM J EPIDEMIOL, V157, P98, DOI 10.1093/aje/kwf182
   Lowe B, 2006, Ther Umsch, V63, P521, DOI 10.1024/0040-5930.63.8.521
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   McIntyre Roger S, 2007, Ann Clin Psychiatry, V19, P257, DOI 10.1080/10401230701653377
   Mehdi S, 2023, BIOCHEM BIOPHYS REP, V36, DOI 10.1016/j.bbrep.2023.101571
   Miklowitz David J, 2009, Clin Psychol (New York), V16, P281
   Misra A, 2008, J CLIN ENDOCR METAB, V93, pS9, DOI 10.1210/jc.2008-1595
   Nebhinani N, 2020, DIAB MET SYND CLIN R, V14, P1997, DOI 10.1016/j.dsx.2020.10.013
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Patel V, 2018, LANCET, V392, P1553, DOI 10.1016/S0140-6736(18)31612-X
   Paul KI, 2009, J VOCAT BEHAV, V74, P264, DOI 10.1016/j.jvb.2009.01.001
   Rajewska-Rager A, 2023, J CLIN MED, V12, DOI 10.3390/jcm12051744
   Ramachandran V, 1982, Indian J Psychiatry, V24, P268
   Reddy M S, 2010, Indian J Psychol Med, V32, P1, DOI 10.4103/0253-7176.70510
   Robles TF, 2003, PHYSIOL BEHAV, V79, P409, DOI 10.1016/S0031-9384(03)00160-4
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Stringhini S, 2017, LANCET, V389, P1229, DOI 10.1016/S0140-6736(16)32380-7
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Whisman MA, 2012, CLIN CHILD FAM PSYCH, V15, P4, DOI 10.1007/s10567-011-0107-2
NR 37
TC 0
Z9 0
U1 3
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0253-7176
EI 0975-1564
J9 INDIAN J PSYCHOL MED
JI Indian J. Psychol. Med.
PD 2025 JAN 19
PY 2025
DI 10.1177/02537176241309032
EA JAN 2025
PG 8
WC Psychiatry; Psychology
WE Emerging Sources Citation Index (ESCI)
SC Psychiatry; Psychology
GA S6A6W
UT WOS:001399032200001
PM 39839149
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Krishnaveni, GV
   Veena, SR
   Dhube, A
   Karat, SC
   Phillips, DIW
   Fall, CHD
AF Krishnaveni, G. V.
   Veena, S. R.
   Dhube, A.
   Karat, S. C.
   Phillips, D. I. W.
   Fall, C. H. D.
TI Size at birth, morning cortisol and cardiometabolic risk markers in
   healthy Indian children
SO CLINICAL ENDOCRINOLOGY
LA English
DT Article
ID CORTICOSTEROID-BINDING GLOBULIN; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   SERUM CORTISOL; PRENATAL STRESS; UNITED-KINGDOM; BLOOD-PRESSURE;
   NEONATAL PIGS; LATER LIFE; WEIGHT
AB ObjectivePrenatal programming of the hypothalamic-pituitary-adrenal (HPA) axis may link reduced foetal growth with higher adult chronic disease risk. South Asians have a high prevalence of low birth weight and a thin-fat phenotype, which is associated with subsequent type 2 diabetes and the metabolic syndrome. Altered HPA activity could be one of the pathological processes underlying this link.
   MethodsPlasma morning cortisol and corticosteroid-binding globulin (CBG) concentrations were determined in 528 children aged 95years from a prospective birth cohort in India. They had detailed anthropometry at birth, and current measurements of anthropometry, plasma glucose, insulin and lipid concentrations and blood pressure. Insulin resistance (Homeostasis Model Assessment) and insulin secretion (the 30-min insulin increment) were also assessed.
   ResultsNone of the birth measurements were associated with cortisol concentrations, but both birth weight (P=003) and length (P=0004) were inversely associated with CBG concentrations. Cortisol concentrations were inversely associated with current body mass index (P=002), and positively associated with glucose (fasting: P<0001; 30-min: P=0002) concentrations, and systolic blood pressure (P=0005), but not insulin resistance or the insulin increment.
   ConclusionHigher morning cortisol is associated with higher cardiometabolic risk markers in Indian children. Although cortisol concentrations did not appear to be related to birth size, small size at birth was associated with higher CBG levels, and may be one of the processes by which foetal undernutrition affects adult health. The findings suggest a need for dynamic testing of HPA axis activity (such as measuring stress responses).
C1 [Krishnaveni, G. V.; Veena, S. R.; Dhube, A.; Karat, S. C.] CSI Holdsworth Mem Hosp, Epidemiol Res Unit, Mysore 570021, South India, India.
   [Phillips, D. I. W.; Fall, C. H. D.] Southampton Gen Hosp, MRC Lifecourse Epidemiol Unit, Southampton SO9 4XY, Hants, England.
C3 University of Southampton
RP Krishnaveni, GV (corresponding author), CSI Holdsworth Mem Hosp, Epidemiol Res Unit, POB 38, Mysore 570021, South India, India.
EM gv.krishnaveni@gmail.com
OI Krishnaveni, Ghattu V/0000-0002-6532-8272; Fall,
   Caroline/0000-0003-4402-5552
FU Parthenon Trust, Switzerland; Wellcome Trust, UK; Medical Research
   Council, UK; MRC [MC_UU_12011/3, MC_UP_A620_1016] Funding Source: UKRI
FX We are grateful to the families who participated, and the obstetric and
   paediatric consultants. We thank Dr Jacqui Hill and staff at the
   Epidemiology Research Unit and the MRC Lifecourse Epidemiology Unit for
   their contributions. Our thanks to Dattatray Bhat, Diabetes Unit, KEM
   Hospital, Pune for biochemical assays, and to Sneha-India for its
   support.This study was funded by the Parthenon Trust, Switzerland, the
   Wellcome Trust, UK and the Medical Research Council, UK.
CR [Anonymous], 2011, Child growth standards
   BERDUSCO ETM, 1994, J ENDOCRINOL, V140, P425, DOI 10.1677/joe.0.1400425
   BRIGHT GM, 1995, J CLIN ENDOCR METAB, V80, P770, DOI 10.1210/jc.80.3.770
   CARPENTER MW, 1982, AM J OBSTET GYNECOL, V144, P768, DOI 10.1016/0002-9378(82)90349-0
   Fall CHD, 2011, ANN HUM BIOL, V38, P410, DOI 10.3109/03014460.2011.592513
   Fall CHD, 2002, J CLIN ENDOCR METAB, V87, P2001, DOI 10.1210/jc.87.5.2001
   HAMMOND GL, 1990, ENDOCR REV, V11, P65, DOI 10.1210/edrv-11-1-65
   Huxley RR, 2000, J HYPERTENS, V18, P815, DOI 10.1097/00004872-200018070-00002
   International Institute for Population Sciences (IIPS) and Operations Research Centre (ORC) Macro, 2001, NFHS2 IIPS ORC MACR
   JANSSON JO, 1989, J ENDOCRINOL, V122, P725, DOI 10.1677/joe.0.1220725
   Jones A, 2006, J CLIN ENDOCR METAB, V91, P1868, DOI 10.1210/jc.2005-2077
   Kanitz E, 2003, J VET MED A, V50, P132, DOI 10.1046/j.1439-0442.2003.00513.x
   Kanitz E, 2006, J ENDOCRINOL, V191, P207, DOI 10.1677/joe.1.06868
   KLEMCKE HG, 1993, J ANIM SCI, V71, P1010, DOI 10.2527/1993.7141010x
   Krishnaveni GV, 2010, J DEV ORIG HLTH DIS, V1, P403, DOI 10.1017/S2040174410000498
   Lay DC, 2008, J ANIM SCI, V86, P1316, DOI 10.2527/jas.2007-0812
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McLaughlin T, 2003, ANN INTERN MED, V139, P802, DOI 10.7326/0003-4819-139-10-200311180-00007
   Morton NM, 2010, MOL CELL ENDOCRINOL, V316, P154, DOI 10.1016/j.mce.2009.09.024
   Musso C, 2011, PEDIATR DIABETES, V12, P229, DOI 10.1111/j.1399-5448.2010.00710.x
   Newsome CA, 2003, DIABETIC MED, V20, P339, DOI 10.1046/j.1464-5491.2003.00871.x
   Phillips DIW, 1998, J CLIN ENDOCR METAB, V83, P757, DOI 10.1210/jc.83.3.757
   Qian XX, 2011, ENDOCRINOLOGY, V152, P3738, DOI 10.1210/en.2011-1008
   Reynolds RM, 2006, CLIN ENDOCRINOL, V64, P530, DOI 10.1111/j.1365-2265.2006.02504.x
   Seckl JR, 2007, NAT CLIN PRACT ENDOC, V3, P479, DOI 10.1038/ncpendmet0515
   Soriano-Rodríguez P, 2010, PEDIATR RES, V68, P452, DOI 10.1203/PDR.0b013e3181efc310
   Syme C, 2008, ARCH PEDIAT ADOL MED, V162, P453, DOI 10.1001/archpedi.162.5.453
   Tanner J.M., 1962, Growth at Adolescence, V2nd ed.
   Tenhola S, 2003, J CLIN ENDOCR METAB, V88, P1217, DOI 10.1210/jc.2002-020903
   Todorova B, 2012, HORM RES PAEDIAT, V77, P298, DOI 10.1159/000338344
   van Montfoort N, 2005, EUR J ENDOCRINOL, V153, P811, DOI 10.1530/eje.1.02050
   Ward AMV, 2003, CLIN ENDOCRINOL, V58, P500, DOI 10.1046/j.1365-2265.2003.01750.x
   Wareham N J, 1995, Diabet Med, V12, P931
   Weigensberg MJ, 2008, J CLIN ENDOCR METAB, V93, P1372, DOI 10.1210/jc.2007-2309
   Yajnik CS, 2004, J NUTR, V134, P205, DOI 10.1093/jn/134.1.205
NR 35
TC 15
Z9 17
U1 0
U2 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD JAN
PY 2014
VL 80
IS 1
BP 73
EP 79
DI 10.1111/cen.12143
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 263IJ
UT WOS:000327801300010
PM 23297873
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Suetani, S
   Mamun, A
   Williams, GM
   Najman, JM
   McGrath, JJ
   Scott, JG
AF Suetani, Shuichi
   Mamun, Abdullah
   Williams, Gail M.
   Najman, Jake M.
   McGrath, John J.
   Scott, James G.
TI Longitudinal association between physical activity engagement during
   adolescence and mental health outcomes in young adults: A 21-year birth
   cohort study
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Physical activity; Common mental disorders; Psychotic disorders;
   Longitudinal study; Epidemiology
ID CARDIOMETABOLIC RISK-FACTORS; AGE-OF-ONSET; SPORT PARTICIPATION;
   DEPRESSIVE SYMPTOMS; DELUSIONAL IDEATION; MATER-UNIVERSITY; LIFE
   EXPECTANCY; DISORDERS; PEOPLE; ANXIETY
AB Objective: Previous studies provide mixed evidence that physical activity engagement (PAE) in adolescence is associated with later mental health outcomes. This study aimed to examine the association between PAE at age 14 and mental health outcomes at age 21 using a large birth cohort study.
   Material and methods: Prospective data from the Mater-University of Queensland Study of Pregnancy, consisting of 3493 young adults, were analyzed. PAE at age 14 was estimated using self-report, and participants were categorized into; (1) frequent, (2) infrequent, or (3) no PAE group. Mental health outcomes at age 21 consisted of; (1) common mental disorders, (2) psychosis-related outcomes, and, (3) emotional and behavioral problems. The association between PAE in adolescence and later mental health outcomes in young adulthood was examined using logistic regression, adjusted for age, sex, body mass index, and adolescent psychopathology.
   Results: No PAE at age 14 was associated with the increased likelihood of lifetime diagnosis of any affective disorder, elevated delusional ideation, and endorsement of visual perceptual disturbance at age 21. Conversely, infrequent PAE at age 14 was associated with the decreased likelihood of subsequent lifetime diagnosis of any substance use disorder.
   Conclusion: Our findings suggest that lack of PAE in adolescence influences some, but not all, later mental health outcomes. Interventions to increase PAE in adolescence may represent an opportunity to prevent future mental health problems. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Suetani, Shuichi; McGrath, John J.; Scott, James G.] Queensland Ctr Mental Hlth Res, Pk Ctr Mental Hlth, Wacol, Qld 4076, Australia.
   [Suetani, Shuichi; McGrath, John J.] Univ Queensland, Queensland Brain Inst, St Lucia, Qld, Australia.
   [Suetani, Shuichi] Metro South Addict & Mental Hlth Serv, Brisbane, Qld, Australia.
   [Mamun, Abdullah] Univ Queensland, Inst Social Sci Res, Indooroopilly, Qld, Australia.
   [Williams, Gail M.; Najman, Jake M.] Univ Queensland, Sch Populat Hlth, Herston, Qld, Australia.
   [Najman, Jake M.] Univ Queensland, Sch Social Sci, St Lucia, Qld, Australia.
   [McGrath, John J.] Aarhus Univ, Natl Ctr Register Based Res, Aarhus C, Denmark.
   [Scott, James G.] Univ Queensland, Ctr Clin Res, Herston, Qld, Australia.
   [Scott, James G.] Royal Brisbane & Womens Hosp, Metro North Mental Hlth, Herston, Qld, Australia.
C3 Queensland Centre for Mental Health Research; University of Queensland;
   University of Queensland; University of Queensland; University of
   Queensland; Aarhus University; University of Queensland; Royal Brisbane
   & Women's Hospital
RP Suetani, S (corresponding author), Queensland Ctr Mental Hlth Res, Pk Ctr Mental Hlth, Wacol, Qld 4076, Australia.
EM shuichi.suetani@health.qld.gov.au
RI Williams, Gail/S-8833-2019; Najman, Jackob/B-1527-2008; McGrath,
   John/G-5493-2010; Scott, James/D-5900-2012; Mamun, Abdullah/A-4673-2011
OI Suetani, Shuichi/0000-0002-2487-5691; Najman,
   Jackob/0000-0001-7079-2080; McGrath, John/0000-0002-4792-6068; Scott,
   James/0000-0002-0744-0688; Mamun, Abdullah/0000-0002-1535-8086;
   Williams, Gail/0000-0002-4822-5263
FU National Health and Medical Research Council (NHMRC grant) [1009460];
   National Health and Medical Research Council Practitioner Fellowship
   Grant [1105807]; National Health and Medical Research Council
   [APP1056929]
FX The MUSP is funded by the National Health and Medical Research Council
   (NHMRC grant #1009460). James G Scott is supported by a National Health
   and Medical Research Council Practitioner Fellowship Grant #1105807 John
   McGrath received John Cade Fellowship APP1056929 from the National
   Health and Medical Research Council.
CR Achenbach T.M., 1997, Manual for the Young Adult Self-Report and Young Adult Behavior Checklist
   Achenbach T.M., 1987, MANUAL YOUTH SELF RE
   [Anonymous], COMP INT DIAGN INT C
   Ashdown-Franks G, 2017, MENT HEALTH PHYS ACT, V12, P19, DOI 10.1016/j.mhpa.2016.12.001
   Babic MJ, 2014, SPORTS MED, V44, P1589, DOI 10.1007/s40279-014-0229-z
   Bauman AE, 2012, LANCET, V380, P258, DOI 10.1016/S0140-6736(12)60735-1
   Birkeland MS, 2009, PSYCHOL SPORT EXERC, V10, P25, DOI 10.1016/j.psychsport.2008.01.005
   Brunet J, 2013, ANN EPIDEMIOL, V23, P25, DOI 10.1016/j.annepidem.2012.10.006
   Cureau FV, 2017, INT J OBESITY, V41, P551, DOI 10.1038/ijo.2016.210
   Eime RM, 2013, INT J BEHAV NUTR PHY, V10, DOI 10.1186/1479-5868-10-98
   Ekelund U, 2012, JAMA-J AM MED ASSOC, V307, P704, DOI 10.1001/jama.2012.156
   Firth J, 2015, PSYCHOL MED, V45, P1343, DOI 10.1017/S0033291714003110
   Flotnes I. S., 2011, Norsk Epidemiologi, V20, P153
   Galletly CA, 2012, AUST NZ J PSYCHIAT, V46, P753, DOI 10.1177/0004867412453089
   Gunnell KE, 2016, PREV MED, V88, P147, DOI 10.1016/j.ypmed.2016.04.002
   Hjorthoj C, 2017, LANCET PSYCHIAT, V4, P295, DOI 10.1016/S2215-0366(17)30078-0
   Janssen I, 2010, INT J BEHAV NUTR PHY, V7, DOI 10.1186/1479-5868-7-40
   Jerstad SJ, 2010, J CONSULT CLIN PSYCH, V78, P268, DOI 10.1037/a0018793
   Jewett R, 2014, J ADOLESCENT HEALTH, V55, P640, DOI 10.1016/j.jadohealth.2014.04.018
   Kessler RC, 2007, WORLD PSYCHIATRY, V6, P168
   Kessler RC, 2007, CURR OPIN PSYCHIATR, V20, P359, DOI 10.1097/YCO.0b013e32816ebc8c
   Koivukangas J, 2010, SCHIZOPHR RES, V116, P152, DOI 10.1016/j.schres.2009.10.022
   Kwan M, 2014, ADDICT BEHAV, V39, P497, DOI 10.1016/j.addbeh.2013.11.006
   Lawrence D, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f2539
   Lee PH, 2011, INT J BEHAV NUTR PHY, V8, DOI 10.1186/1479-5868-8-115
   Lisha NE, 2014, J DRUG ISSUES, V44, P83, DOI 10.1177/0022042613491107
   Mammen G, 2013, AM J PREV MED, V45, P649, DOI 10.1016/j.amepre.2013.08.001
   McGrath JJ, 2016, AM J PSYCHIAT, V173, P997, DOI 10.1176/appi.ajp.2016.15101293
   McGrath JJ, 2016, AUST NZ J PSYCHIAT, V50, P577, DOI 10.1177/0004867415587341
   Mills NT, 2013, J CHILD PSYCHOL PSYC, V54, P816, DOI 10.1111/jcpp.12080
   Moylan S, 2013, NEUROSCI BIOBEHAV R, V37, P573, DOI 10.1016/j.neubiorev.2013.02.003
   Najman JM, 2015, INT J EPIDEMIOL, V44, P78, DOI 10.1093/ije/dyu234
   Najman JM, 2005, INT J EPIDEMIOL, V34, P992, DOI 10.1093/ije/dyi119
   Okkenhaug A, 2016, NORD J PSYCHIAT, V70, P111, DOI 10.3109/08039488.2015.1055300
   Peters E, 2004, SCHIZOPHRENIA BULL, V30, P1005, DOI 10.1093/oxfordjournals.schbul.a007116
   Peters ER, 1999, SCHIZOPHRENIA BULL, V25, P553, DOI 10.1093/oxfordjournals.schbul.a033401
   Poulsen PH, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-015-2658-5
   ROSE G, 1981, BMJ-BRIT MED J, V282, P1847, DOI 10.1136/bmj.282.6279.1847
   Rosenbaum S, 2016, AUSTRALAS PSYCHIATRY, V24, P49, DOI 10.1177/1039856215590252
   Rothon C, 2010, BMC MED, V8, DOI 10.1186/1741-7015-8-32
   Sagatun A, 2007, BMC PUBLIC HEALTH, V7, DOI 10.1186/1471-2458-7-155
   Schuch F, 2017, J AFFECT DISORDERS, V210, P139, DOI 10.1016/j.jad.2016.10.050
   Schuch FB, 2016, J PSYCHIATR RES, V77, P42, DOI 10.1016/j.jpsychires.2016.02.023
   Scott KM, 2008, INT J OBESITY, V32, P192, DOI 10.1038/sj.ijo.0803701
   Scott KM, 2016, JAMA PSYCHIAT, V73, P150, DOI 10.1001/jamapsychiatry.2015.2688
   Sormunen E, 2017, NPJ SCHIZOPHR, V3, DOI 10.1038/s41537-016-0007-z
   Ströhle A, 2007, PSYCHOL MED, V37, P1657, DOI 10.1017/S003329170700089X
   Stubbs B, 2017, PSYCHIAT RES, V249, P102, DOI 10.1016/j.psychres.2016.12.020
   Stubbs B, 2016, SCHIZOPHR RES, V176, P431, DOI 10.1016/j.schres.2016.05.017
   Suetani S, 2016, ACTA PSYCHIAT SCAND, V134, P129, DOI 10.1111/acps.12594
   Toseeb U, 2014, JAMA PEDIATR, V168, P1093, DOI 10.1001/jamapediatrics.2014.1794
   Walker ER, 2015, JAMA PSYCHIAT, V72, P334, DOI 10.1001/jamapsychiatry.2014.2502
   Welham J, 2009, SCHIZOPHRENIA BULL, V35, P603, DOI 10.1093/schbul/sbn084
NR 53
TC 21
Z9 23
U1 0
U2 46
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD NOV
PY 2017
VL 94
BP 116
EP 123
DI 10.1016/j.jpsychires.2017.06.013
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FJ7TD
UT WOS:000412960900015
PM 28704729
DA 2025-06-11
ER

PT J
AU Basu, A
AF Basu, Arpita
TI Role of Berry Bioactive Compounds on Lipids and Lipoproteins in Diabetes
   and Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE Lipids; Lipoproteins; cranberry; blueberry; strawberry; LDL; metabolic
   syndrome
ID HDL-CHOLESTEROL CONCENTRATIONS; CRANBERRY JUICE CONSUMPTION;
   EUTERPE-OLERACEA MART.; ESTER TRANSFER PROTEIN; C-REACTIVE PROTEIN;
   OXIDATIVE STRESS; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE;
   CARDIOMETABOLIC RISK; INSULIN-RESISTANCE
AB Blood lipids are an important biomarker of cardiovascular health and disease. Among the lipid biomarkers that have been widely used to monitor and predict cardiovascular diseases (CVD), elevated LDL and low HDL cholesterol (C), as well as elevated triglyceride-rich lipoproteins, deserve special attention in their predictive abilities, and thus have been the targets of several therapeutic and dietary approaches to improving lipid profiles. Among natural foods and nutraceuticals, dietary berries are a rich source of nutrients, fiber, and various types of phytochemicals. Berries as whole fruits, juices, and purified extracts have been shown to lower total and LDL-C, and increase HDL-C in clinical studies in participants with elevated blood lipids, type 2 diabetes or metabolic syndrome. This short review aimed to further discuss the mechanisms and magnitude of the lipid-lowering effects of dietary berries, with emphasis on reported clinical studies. Based on the emerging evidence, colorful berry fruits may thus be included in a healthy diet for the prevention and management of CVD.
C1 [Basu, Arpita] Univ Nevada, Sch Integrated Hlth Sci, Dept Kinesiol & Nutr Sci, 4505 S Maryland Pkwy, Las Vegas, NV 89154 USA.
C3 Nevada System of Higher Education (NSHE); University of Nevada Las Vegas
RP Basu, A (corresponding author), Univ Nevada, Sch Integrated Hlth Sci, Dept Kinesiol & Nutr Sci, 4505 S Maryland Pkwy, Las Vegas, NV 89154 USA.
EM Arpita.basu@unlv.edu
CR [Anonymous], ARCH INTERN MED
   Arnett DK, 2019, CIRCULATION, V140, pE563, DOI [10.1016/j.jacc.2019.03.009, 10.1016/j.jacc.2019.03.010, 10.1161/CIR.0000000000000678, 10.1161/CIR.0000000000000677]
   Arsenault Benoit J, 2009, J Am Coll Cardiol, V55, P35, DOI 10.1016/j.jacc.2009.07.057
   Basu A, 2016, ATHEROSCLEROSIS, V244, P93, DOI 10.1016/j.atherosclerosis.2015.10.106
   Basu A, 2014, J NUTR, V144, P830, DOI 10.3945/jn.113.188169
   Basu A, 2014, CRIT REV FOOD SCI, V54, P790, DOI 10.1080/10408398.2011.608174
   Basu A, 2011, NUTR RES, V31, P190, DOI 10.1016/j.nutres.2011.02.003
   Basu A, 2010, NUTR RES, V30, P462, DOI 10.1016/j.nutres.2010.06.016
   Basu A, 2010, J NUTR, V140, P1582, DOI 10.3945/jn.110.124701
   Basu A, 2010, NUTR REV, V68, P168, DOI 10.1111/j.1753-4887.2010.00273.x
   Broncel M, 2010, MED SCI MONITOR, V16, pCR28
   Burton-Freeman B, 2010, J AM COLL NUTR, V29, P46, DOI 10.1080/07315724.2010.10719816
   Cassidy A, 2013, CIRCULATION, V127, P188, DOI 10.1161/CIRCULATIONAHA.112.122408
   Simao TNC, 2013, BRIT J NUTR, V110, P1885, DOI 10.1017/S0007114513001207
   de Souza MO, 2012, NUTR RES, V32, P976, DOI 10.1016/j.nutres.2012.10.001
   de Souza MO, 2010, NUTRITION, V26, P804, DOI 10.1016/j.nut.2009.09.007
   Djoussé L, 2004, AM J CLIN NUTR, V79, P213
   Duffey KJ, 2013, NUTRIENTS, V5, P4938, DOI 10.3390/nu5124938
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Fu JY, 2015, CIRC RES, V117, P817, DOI 10.1161/CIRCRESAHA.115.306807
   Garvey WT, 2003, DIABETES, V52, P453, DOI 10.2337/diabetes.52.2.453
   INAZU A, 1990, NEW ENGL J MED, V323, P1234, DOI 10.1056/NEJM199011013231803
   Jaroslawska J, 2011, J NUTR, V141, P1777, DOI 10.3945/jn.111.143677
   Jennings A, 2014, J NUTR, V144, P202, DOI 10.3945/jn.113.184358
   Jiang R, 2004, DIABETES CARE, V27, P1991, DOI 10.2337/diacare.27.8.1991
   Johnson SA, 2015, J ACAD NUTR DIET, V115, P369, DOI 10.1016/j.jand.2014.11.001
   Kastelein JJP, 2008, CIRCULATION, V117, P3002, DOI 10.1161/CIRCULATIONAHA.107.713438
   Khanal RC, 2012, J MED FOOD, V15, P802, DOI 10.1089/jmf.2011.0212
   Kianbakht S, 2014, PHYTOTHER RES, V28, P432, DOI 10.1002/ptr.5011
   Lankinen M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0090352
   Lee IT, 2008, DIABETIC MED, V25, P1473, DOI 10.1111/j.1464-5491.2008.02588.x
   Madeeha IR, 2016, INT J FOOD SCI NUTR, V67, P865, DOI 10.1080/09637486.2016.1201791
   Manach C, 2004, AM J CLIN NUTR, V79, P727, DOI 10.1093/ajcn/79.5.727
   Mandave P, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18010124
   Mirmiran P, 2015, EUR J CLIN NUTR, V69, P1215, DOI 10.1038/ejcn.2015.49
   Novotny JA, 2015, J NUTR, V145, P1185, DOI 10.3945/jn.114.203190
   Ouchi N, 2000, CIRCULATION, V102, P1296, DOI 10.1161/01.CIR.102.11.1296
   Ouchi N, 1999, CIRCULATION, V100, P2473, DOI 10.1161/01.CIR.100.25.2473
   Pereira RR, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/8379105
   Qin Y, 2009, AM J CLIN NUTR, V90, P485, DOI 10.3945/ajcn.2009.27814
   Ray KK, 2009, ARTERIOSCL THROM VAS, V29, P424, DOI 10.1161/ATVBAHA.108.181735
   Ruel G, 2006, BRIT J NUTR, V96, P357, DOI 10.1079/BJN20061814
   Sesso HD, 2007, J AM COLL NUTR, V26, P303, DOI 10.1080/07315724.2007.10719615
   Silverman MG, 2016, JAMA-J AM MED ASSOC, V316, P1289, DOI 10.1001/jama.2016.13985
   Soltani R, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/217451
   Ströher DJ, 2015, INT J FOOD SCI NUTR, V66, P559, DOI 10.3109/09637486.2015.1064870
   von Ballmoos MCW, 2015, J CLIN LIPIDOL, V9, P498, DOI 10.1016/j.jacl.2015.05.002
   Wedick NM, 2012, AM J CLIN NUTR, V95, P925, DOI 10.3945/ajcn.111.028894
   Zhu YN, 2011, CLIN CHEM, V57, P1524, DOI 10.1373/clinchem.2011.167361
   Zhu YT, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/790329
   Zunino SJ, 2012, BRIT J NUTR, V108, P900, DOI 10.1017/S0007114511006027
NR 51
TC 27
Z9 28
U1 3
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2019
VL 11
IS 9
AR 1983
DI 10.3390/nu11091983
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA JA6PP
UT WOS:000487964600062
PM 31443489
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Oliveira, CP
   Sanches, PD
   de Abreu-Silva, EO
   Marcadenti, A
AF Oliveira, Claudia P.
   Sanches, Priscila de Lima
   de Abreu-Silva, Erlon Oliveira
   Marcadenti, Aline
TI Nutrition and Physical Activity in Nonalcoholic Fatty Liver Disease
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Review
ID MODERATE ALCOHOL-CONSUMPTION; HEPATIC STEATOSIS; INSULIN-RESISTANCE;
   MEDITERRANEAN DIET; WEIGHT-LOSS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   SKELETAL-MUSCLE; RISK-FACTORS; VITAMIN-E
AB Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and it is associated with other medical conditions such as diabetes mellitus, metabolic syndrome, and obesity. The mechanisms of the underlying disease development and progression are not completely established and there is no consensus concerning the pharmacological treatment. In the gold standard treatment for NAFLD weight loss, dietary therapy, and physical activity are included. However, little scientific evidence is available on diet and/or physical activity and NAFLD specifically. Many dietary approaches such asMediterranean and DASH diet are used for treatment of other cardiometabolic risk factors such as insulin resistance and type-2 diabetes mellitus (T2DM), but on the basis of its components their role in NAFLD has been discussed. In this review, the implications of current dietary and exercise approaches, including Brazilian and other guidelines, are discussed, with a focus on determining the optimal nonpharmacological treatment to prescribe for NAFLD.
C1 [Oliveira, Claudia P.] Univ Sao Paulo, Sch Med, Dept Gastroenterol, BR-05403900 Sao Paulo, SP, Brazil.
   [Sanches, Priscila de Lima] Fed Univ Sao Paulo UNIFESP, Postgrad Program Nutr, BR-04020060 Sao Paulo, SP, Brazil.
   [de Abreu-Silva, Erlon Oliveira] Fed Univ Sao Paulo UNIFESP, Div Intervent Cardiol, BR-04024002 Sao Paulo, SP, Brazil.
   [de Abreu-Silva, Erlon Oliveira] Fed Univ Sao Paulo UNIFESP, Postgrad Program Cardiol, BR-04024002 Sao Paulo, SP, Brazil.
   [Marcadenti, Aline] Fed Univ Hlth Sci Porto Alegre UFCSPA, Dept Nutr, Ctr Hist, BR-90050170 Porto Alegre, RS, Brazil.
   [Marcadenti, Aline] Inst Cardiol Rio Grande do Sul IC FUC, Postgrad Program Hlth Sci Cardiol, BR-90040371 Porto Alegre, RS, Brazil.
C3 Universidade de Sao Paulo; Universidade Federal de Sao Paulo (UNIFESP);
   Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Sao
   Paulo (UNIFESP); Universidade Federal de Ciencias da Saude de Porto
   Alegre; Fundacao Universitaria de Cardiologia
RP Marcadenti, A (corresponding author), Fed Univ Hlth Sci Porto Alegre UFCSPA, Dept Nutr, Ctr Hist, 245 Sarmento Leite St, BR-90050170 Porto Alegre, RS, Brazil.
EM marcadenti@yahoo.com.br
RI Oliveira, Claudia/D-1216-2014; de Abreu Silva, Erlon/AAV-2842-2020;
   Marcadenti, Aline/A-8085-2012
OI P Oliveira, Claudia/0000-0002-2848-417X; Oliveira de Abreu-Silva,
   Erlon/0000-0003-1089-0716
CR Abdul-Hai A, 2015, WORLD J HEPATOL, V7, P1679, DOI 10.4254/wjh.v7.i12.1679
   Abenavoli L, 2015, WORLD J HEPATOL, V7, P1723, DOI 10.4254/wjh.v7.i12.1723
   Aguirre L, 2014, WORLD J GASTROENTERO, V20, P7366, DOI 10.3748/wjg.v20.i23.7366
   Albano E, 2005, GUT, V54, P987, DOI 10.1136/gut.2004.057968
   Aller R, 2014, EUR REV MED PHARMACO, V18, P1041
   Angelico F, 2005, J CLIN ENDOCR METAB, V90, P1578, DOI 10.1210/jc.2004-1024
   [Anonymous], J CLIN ENDOCRINOLOGY
   [Anonymous], BIOMEDICAL PAPERS
   [Anonymous], SCI WORLD J
   [Anonymous], DIABETES CARE S1
   [Anonymous], GUT
   Bellentani S, 2010, DIGEST DIS, V28, P155, DOI 10.1159/000282080
   Duarte SMB, 2014, NUTR HOSP, V29, P94
   Bozzetto L, 2012, DIABETES CARE, V35, P1429, DOI 10.2337/dc12-0033
   Brandt C, 2010, J BIOMED BIOTECHNOL, DOI 10.1155/2010/520258
   Brunt EM, 1999, AM J GASTROENTEROL, V94, P2467, DOI 10.1111/j.1572-0241.1999.01377.x
   Buss C, 2014, ANN HEPATOL, V13, P482, DOI 10.1016/S1665-2681(19)31246-3
   Byrne CD, 2009, CLIN SCI, V116, P539, DOI 10.1042/CS20080253
   Capanni M, 2006, ALIMENT PHARM THER, V23, P1143, DOI 10.1111/j.1365-2036.2006.02885.x
   Castéra L, 2005, GASTROENTEROLOGY, V128, P343, DOI 10.1053/j.gastro.2004.11.018
   Chai JW, 2001, J MAGN RESON IMAGING, V14, P35, DOI 10.1002/jmri.1148
   Chalasani N, 2012, HEPATOLOGY, V55, P2005, DOI 10.1002/hep.25762
   Chen SH, 2015, DIGEST LIVER DIS, V47, P226, DOI 10.1016/j.dld.2014.11.015
   Chung M, 2014, AM J CLIN NUTR, V100, P833, DOI 10.3945/ajcn.114.086314
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   Dongiovanni P, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0116855
   Dubé JJ, 2008, AM J PHYSIOL-ENDOC M, V294, pE882, DOI 10.1152/ajpendo.00769.2007
   Dunn W, 2012, J HEPATOL, V57, P384, DOI 10.1016/j.jhep.2012.03.024
   Elias MC, 2010, NUTRITION, V26, P1094, DOI 10.1016/j.nut.2009.09.001
   Faghihzadeh F, 2014, NUTR RES, V34, P837, DOI 10.1016/j.nutres.2014.09.005
   Farrell GC, 2006, HEPATOLOGY, V43, pS99, DOI 10.1002/hep.20973
   Feldstein AE, 2010, SEMIN LIVER DIS, V30, P391, DOI 10.1055/s-0030-1267539
   Finelli C, 2012, WORLD J GASTROENTERO, V18, P6790, DOI 10.3748/wjg.v18.i46.6790
   George AS, 2009, HEPATOLOGY, V50, P68, DOI 10.1002/hep.22940
   Georgoulis M, 2015, NUTR RES, V35, P41, DOI 10.1016/j.nutres.2014.11.004
   Gunji T, 2009, AM J GASTROENTEROL, V104, P2189, DOI 10.1038/ajg.2009.361
   Hallsworth K, 2011, GUT, V60, P1278, DOI 10.1136/gut.2011.242073
   Hickman IJ, 2004, GUT, V53, P413, DOI 10.1136/gut.2003.027581
   Holten MK, 2004, DIABETES, V53, P294, DOI 10.2337/diabetes.53.2.294
   Hu T, 2012, AM J EPIDEMIOL, V176, pS44, DOI 10.1093/aje/kws264
   Iacono A, 2011, J NUTR BIOCHEM, V22, P699, DOI 10.1016/j.jnutbio.2010.10.002
   Ji HF, 2014, NUTRITION, V30, P986, DOI 10.1016/j.nut.2014.01.016
   Jia Q, 2015, EUR J CLIN NUTR, V69, P914, DOI 10.1038/ejcn.2014.297
   Jiang XB, 2014, EUR J NUTR, V53, P25, DOI 10.1007/s00394-013-0603-x
   Johnson NA, 2010, HEPATOLOGY, V52, P370, DOI 10.1002/hep.23711
   Johnson NA, 2009, HEPATOLOGY, V50, P1105, DOI 10.1002/hep.23129
   Kani AH, 2014, NUTRITION, V30, P814, DOI 10.1016/j.nut.2013.11.008
   Kargulewicz A, 2014, PRZ GASTROENTEROL, V9, P18, DOI 10.5114/pg.2014.40845
   Kikuchi L, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/106247
   Kontogianni MD, 2014, CLIN NUTR, V33, P678, DOI 10.1016/j.clnu.2013.08.014
   Kowdley KV, 2012, HEPATOLOGY, V55, P77, DOI 10.1002/hep.24706
   Kruse M, 2015, MOL NUTR FOOD RES, V59, P507, DOI 10.1002/mnfr.201400446
   Lavoie JM, 2006, CELL MOL LIFE SCI, V63, P1393, DOI 10.1007/s00018-006-6600-y
   Leite NC, 2014, WORLD J GASTROENTERO, V20, P8377, DOI 10.3748/wjg.v20.i26.8377
   Lytvynenko K O, 2014, Lik Sprava, P82
   Ma YY, 2013, WORLD J GASTROENTERO, V19, P6911, DOI 10.3748/wjg.v19.i40.6911
   Domínguez VM, 2013, REV ESP ENFERM DIG, V105, P409, DOI 10.4321/S1130-01082013000700006
   Masarone M, 2014, REV RECENT CLIN TRIA, V9, P126, DOI 10.2174/1574887109666141216111143
   Masterton GS, 2010, ALIMENT PHARM THER, V31, P679, DOI 10.1111/j.1365-2036.2010.04230.x
   Miele L, 2009, HEPATOLOGY, V49, P1877, DOI 10.1002/hep.22848
   Moschen AR, 2008, CURR OPIN CLIN NUTR, V11, P620, DOI 10.1097/MCO.0b013e32830b5d09
   Nabavi S, 2014, J DAIRY SCI, V97, P7386, DOI 10.3168/jds.2014-8500
   Nagle CA, 2009, J LIPID RES, V50, pS74, DOI 10.1194/jlr.R800053-JLR200
   Oh S, 2013, MED SCI SPORT EXER, V45, P2214, DOI 10.1249/MSS.0b013e31829afc33
   Oliveira CPMS, 2002, J CELL MOL MED, V6, P399, DOI 10.1111/j.1582-4934.2002.tb00518.x
   Parnell JA, 2012, LIVER INT, V32, P701, DOI 10.1111/j.1478-3231.2011.02730.x
   Petta S, 2009, DIGEST LIVER DIS, V41, P615, DOI 10.1016/j.dld.2009.01.004
   Promrat K, 2010, HEPATOLOGY, V51, P121, DOI 10.1002/hep.23276
   Reiner Z, 2011, EUR HEART J, V32, P1769, DOI [10.1016/j.atherosclerosis.2011.06.012, 10.1093/eurheartj/ehr158]
   Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012
   Salehi-Abargouei A, 2013, NUTRITION, V29, P611, DOI 10.1016/j.nut.2012.12.018
   Santos RD, 2013, ARQ BRAS CARDIOL, V100, P1
   Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929
   Schenk S, 2007, J CLIN INVEST, V117, P1690, DOI 10.1172/JCI30566
   Schugar RC, 2012, CURR OPIN CLIN NUTR, V15, P374, DOI 10.1097/MCO.0b013e3283547157
   Seitz HK, 2015, HEPATOBIL SURG NUTR, V4, P147, DOI 10.3978/j.issn.2304-3881.2014.12.01
   Shirani F, 2013, NUTRITION, V29, P939, DOI 10.1016/j.nut.2012.12.021
   Slentz CA, 2011, AM J PHYSIOL-ENDOC M, V301, pE1033, DOI 10.1152/ajpendo.00291.2011
   Sookoian S, 2014, GUT, V63, P530, DOI 10.1136/gutjnl-2013-305718
   Suzuki A, 2005, J HEPATOL, V43, P1060, DOI 10.1016/j.jhep.2005.06.008
   Suzuki A, 2007, AM J GASTROENTEROL, V102, P1912, DOI 10.1111/j.1572-0241.2007.01274.x
   Taylor R, 2008, DIABETOLOGIA, V51, P1781, DOI 10.1007/s00125-008-1116-7
   Trauner M, 2010, BBA-MOL CELL BIOL L, V1801, P299, DOI 10.1016/j.bbalip.2009.10.007
   Van Beers BE, 2003, MAGN RESON MED, V49, P692, DOI 10.1002/mrm.10420
   Velasco N, 2014, CURR OPIN CLIN NUTR, V17, P453, DOI 10.1097/MCO.0000000000000071
   Walsh NP, 2011, EXERC IMMUNOL REV, V17, P64
   Westerbacka J, 2005, J CLIN ENDOCR METAB, V90, P2804, DOI 10.1210/jc.2004-1983
   Williamson RM, 2011, DIABETES CARE, V34, P1139, DOI 10.2337/dc10-2229
   Xian-Cheng J, 2005, J BIOL CHEM, V280, P18336, DOI 10.1074/jbc.M500007200
   Youssef WI, 2002, BEST PRACT RES CL GA, V16, P733, DOI 10.1053/bega.2002.0334
   Zamara E, 2004, J HEPATOL, V40, P60, DOI 10.1016/S0168-8278(03)00480-X
   Zivkovic AM, 2007, AM J CLIN NUTR, V86, P285, DOI 10.1093/ajcn/86.2.285
NR 92
TC 44
Z9 45
U1 0
U2 20
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PY 2016
VL 2016
AR 4597246
DI 10.1155/2016/4597246
PG 12
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA DB2VD
UT WOS:000368367300001
PM 26770987
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Brborovic, O
   Rukavina, TV
   Pavlekovic, G
   Dzakula, A
   Sogoric, S
   Vuletic, S
AF Brborovic, Ognjen
   Rukavina, Tea Vukusic
   Pavlekovic, Gordana
   Dzakula, Aleksandar
   Sogoric, Selma
   Vuletic, Silvije
TI Psychological Distress within Cardiovascular Risks Behaviors, Conditions
   and Diseases Conceptual Framework
SO COLLEGIUM ANTROPOLOGICUM
LA English
DT Article
DE psychological distress; cardiovascular disease; health behavior;
   Croatian Adult Health Survey; Croatia
ID CORONARY-HEART-DISEASE; SF-36 HEALTH SURVEY; MENTAL-HEALTH; METABOLIC
   SYNDROME; GENERAL-POPULATION; PROSPECTIVE COHORT; MAJOR DEPRESSION;
   WHITEHALL-II; VALIDITY; EPIDEMIOLOGY
AB Psychological distress (PD) is being increasingly recognized as a risk factor for cardiovascular diseases (CVD). Our aim was to recognize an association of PD and CVD in the Croatian adult population. We also explored association's strength obtainable as relative risk of PD on three levels; cardiovascular risk behaviors, conditions and diseases. This study used Croatian Adult Health Survey 2003 (CAHS 2003) data (N = 9,070). PD status was measured by the five-item Mental Health Scale of the Short Form questionnaire (SF-36) hence one distinguished subgroup consisted of population with PD and other without PD. Prevalence of cardiovascular risk behaviors, cardiovascular risk conditions and self-reported cardiovascular diseases within each subgroup were calculated using bootstrap method. Women had higher prevalence of PD in general population. Among distressed population women had higher prevalence of body mass index over 30, metabolic syndrome and angina pectoris. Men with PD had higher prevalence of high blood pressure and myocardial infarction with contradictoty lower prevalence of angina pectoris then Myocardial infarction. Physical inactivity was proven to be a risk behavior determinant with most impact on Mental health. All CVD are consistently associated with higher prevalence and relative risks for PD both in men and women.
C1 [Brborovic, Ognjen; Pavlekovic, Gordana; Dzakula, Aleksandar; Sogoric, Selma] Univ Zagreb, Sch Med, Andrija Stampar Sch Publ Hlth, Dept Social Med & Org Healthcare, Zagreb 10000, Croatia.
   [Rukavina, Tea Vukusic] Univ Zagreb, Sch Med, Andrija Stampar Sch Publ Hlth, Dept Med Sociol & Hlth Econ, Zagreb 10000, Croatia.
   [Vuletic, Silvije] Univ Zagreb, Sch Med, Andrija Stampar Sch Publ Hlth, Dept Med Stat Epidemiol & Med Informat, Zagreb 10000, Croatia.
C3 University of Zagreb; University of Zagreb; University of Zagreb
RP Brborovic, O (corresponding author), Univ Zagreb, Sch Med, Andrija Stampar Sch Publ Hlth, Dept Social Med & Org Healthcare, Rockefellerova 4, Zagreb 10000, Croatia.
EM obrborov@snz.hr
RI Vukusic Rukavina, Tea/ABH-3238-2021; Sogoric, Selma/LEM-9765-2024;
   Brborovic, Ognjen/AAF-1651-2020; Dzakula, Aleksandar/ITT-3971-2023
OI Sogoric, Selma/0000-0002-2314-2146; Dzakula,
   Aleksandar/0000-0002-0013-3108; Vukusic Rukavina,
   Tea/0000-0002-6466-9024
CR ASSOCIATION AH, 2008, OUR 2006 DIET LIF RE
   Bécue-Bertaut M, 2008, PUBLIC HEALTH, V122, P140, DOI 10.1016/j.puhe.2007.05.009
   BELLAND Y, 2004, P M SURV RES METH AM
   BERWICK DM, 1991, MED CARE, V29, P169, DOI 10.1097/00005650-199102000-00008
   Chen HJ, 2006, STROKE, V37, P1060, DOI 10.1161/01.STR.0000206458.58142.f3
   DOHRENWEND BP, 1980, ARCH GEN PSYCHIAT, V37, P1229
   Farmer A, 2006, BRIT MED J, V332, P882, DOI 10.1136/bmj.332.7546.882
   Farmer John A, 2004, Curr Cardiol Rep, V6, P427, DOI 10.1007/s11886-004-0050-7
   Fauci AS, 2001, Harrisons Principles of Internal Medicine, V15th
   Ferketich AK, 2005, EUR HEART J, V26, P1923, DOI 10.1093/eurheartj/ehi329
   Friedman B, 2005, J AM GERIATR SOC, V53, P1978, DOI 10.1111/j.1532-5415.2005.00469.x
   Gandhi MM, 1997, BRIT J HOSP MED, V58, P23
   Gill SC, 2007, PSYCHIAT RES, V152, P63, DOI 10.1016/j.psychres.2006.11.005
   Gogia Atul, 2006, Indian J Med Sci, V60, P72
   Hemingway H, 1999, BMJ-BRIT MED J, V318, P1460, DOI 10.1136/bmj.318.7196.1460
   HO KKL, 1993, J AM COLL CARDIOL, V22, pA6, DOI 10.1016/0735-1097(93)90455-A
   Holmes WC, 1998, MED CARE, V36, P237, DOI 10.1097/00005650-199802000-00012
   Kelly M., 2008, BMC PSYCHIATRY, P8
   Kern J, 2005, BRIT MED J, V331, P208, DOI 10.1136/bmj.331.7510.208
   König D, 2007, HERZ, V32, P553, DOI 10.1007/s00059-007-3019-7
   Kolcic I, 2006, CROAT MED J, V47, P585
   Kovess V., 2004, STATE MENTAL HLTH EU
   Malyutina S, 2002, LANCET, V360, P1448, DOI 10.1016/S0140-6736(02)11470-X
   Means-Christensen AJ, 2005, J BEHAV MED, V28, P565, DOI 10.1007/s10865-005-9023-6
   Nabi H, 2008, ARTERIOSCL THROM VAS, V28, P1398, DOI 10.1161/ATVBAHA.108.167239
   *NHS DOH, COR HEART DIS
   Rasul F, 2007, PSYCHOL MED, V37, P1305, DOI 10.1017/S0033291707000402
   Rumpf HJ, 2001, PSYCHIAT RES, V105, P243, DOI 10.1016/S0165-1781(01)00329-8
   Stansfeld SA, 2002, INT J EPIDEMIOL, V31, P248, DOI 10.1093/ije/31.1.248
   Turek S, 2001, COLLEGIUM ANTROPOL, V25, P77
   VULETIC S, 2007, ACTA MED CROATICA, V61
   Vuletic S, 2009, COLLEGIUM ANTROPOL, V33, P3
   Ware JE, 1998, J CLIN EPIDEMIOL, V51, P903, DOI 10.1016/S0895-4356(98)00081-X
   Ware JE, 2000, SPINE, V25, P3130, DOI 10.1097/00007632-200012150-00008
   Winston M, 2000, SOC PSYCH PSYCH EPID, V35, P569, DOI 10.1007/s001270050281
NR 35
TC 10
Z9 11
U1 0
U2 9
PU COLLEGIUM ANTROPOLOGICUM
PI ZAGREB
PA INST ANTHROPOLOGICAL RESEARCH, GAJEVA 32, PO BOX 290, HR-10000 ZAGREB,
   CROATIA
SN 0350-6134
J9 COLLEGIUM ANTROPOL
JI Coll. Anthropol.
PD APR
PY 2009
VL 33
SU 1
BP 93
EP 98
PG 6
WC Anthropology
WE Social Science Citation Index (SSCI)
SC Anthropology
GA 446KR
UT WOS:000266121000016
PM 19563153
DA 2025-06-11
ER

PT J
AU Takeuchi, T
   Nakao, M
   Kachi, Y
   Yano, E
AF Takeuchi, Takeaki
   Nakao, Mutsuhiro
   Kachi, Yuko
   Yano, Eiji
TI Association of metabolic syndrome with atypical features of depression
   in Japanese people
SO PSYCHIATRY AND CLINICAL NEUROSCIENCES
LA English
DT Article
DE atypical depression; hyperphagia; Japan; major depression; metabolic
   syndrome
ID MAJOR DEPRESSION; HEALTH; ANXIETY; SYMPTOMATOLOGY; POPULATION;
   PREVALENCE; SYMPTOMS; RISK
AB AimIt has been controversial whether metabolic syndrome (MetS) is associated with depression. We aimed to clarify the correlation between MetS and depression, considering atypical features of depression.
   MethodsParticipants were 1011 Japanese men aged 20-59 years. MetS was diagnosed according to criteria set by the International Diabetes Federation. Clinical interviews for major depressive disorder (MDD) employed the DSM-IV; MDD was classified into atypical and non-atypical types. The prevalence of MetS was compared between the groups with no MDD, atypical depression, and non-atypical depression via trend analyses. Multiple logistic regression analyses examined the association of MetS with atypical depression and the features thereof.
   ResultsIn total, 141 (14.0%) participants were diagnosed with MetS and 57 (5.6%) were diagnosed with MDD (14 had atypical and 43 had non-atypicalMDD). The prevalence of MetS was the highest in the group with atypical depression, followed by the non-atypical depression and no MDD groups, respectively, with a marginally significant trend (P=0.07). The adjusted odds ratios of MetS associated with depression were 3.8 (95% confidence interval [CI] 1.1-13.2) for atypical depression and 1.6 (95%CI 0.7-3.6) for non-atypical depression. Among the five features of atypical depression, only hyperphagia was significantly related to MetS (odds ratio 2.7, 95%CI 1.8-4.1).
   ConclusionThere was a positive association between MetS and atypical depression, but not between MetS and non-atypical depression. Specifically, hyperphagia seems to be an important factor affecting the correlation between MetS and atypical depression.
C1 [Takeuchi, Takeaki; Nakao, Mutsuhiro; Kachi, Yuko; Yano, Eiji] Teikyo Univ, Sch Med, Dept Hyg & Publ Hlth, Tokyo 1738605, Japan.
   [Takeuchi, Takeaki; Nakao, Mutsuhiro] Teikyo Univ Hosp, Div Psychosomat Med, Tokyo, Japan.
C3 Teikyo University; Teikyo University
RP Takeuchi, T (corresponding author), Teikyo Univ, Sch Med, Dept Hyg & Publ Hlth, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738605, Japan.
EM takeakij@post.harvard.edu
CR Akbaraly TN, 2009, DIABETES CARE, V32, P499, DOI 10.2337/dc08-1358
   Almeida OP, 2009, AM J GERIAT PSYCHIAT, V17, P889, DOI 10.1097/JGP.0b013e3181b047e3
   American Psychiatric Association, 2000, DSM 4 TR DIAGN STAT
   [Anonymous], 2001, The world health report-mental health: New understanding, new hope
   [Anonymous], PSYCHIAT CLIN N AM
   [Anonymous], 2006, IDF CONS WORLDW DEF
   Carroll D, 2009, BIOL PSYCHIAT, V66, P91, DOI 10.1016/j.biopsych.2009.02.020
   Foley DL, 2010, TWIN RES HUM GENET, V13, P347, DOI 10.1375/twin.13.4.347
   Health and Welfare Statistics Association, 2005, PAT SURV, VI
   Hildrum B, 2009, ACTA PSYCHIAT SCAND, V120, P14, DOI 10.1111/j.1600-0447.2008.01315.x
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Kahl KG, 2012, EUR ARCH PSY CLIN N, V262, P313, DOI 10.1007/s00406-011-0277-4
   Kawakami N, 2005, PSYCHIAT CLIN NEUROS, V59, P441, DOI 10.1111/j.1440-1819.2005.01397.x
   Lamers F, 2010, J CLIN PSYCHIAT, V71, P1582, DOI 10.4088/JCP.09m05398blu
   Mast BT, 2008, BIOL PSYCHIAT, V64, P320, DOI 10.1016/j.biopsych.2008.01.025
   McIntyre Roger S, 2007, Ann Clin Psychiatry, V19, P257, DOI 10.1080/10401230701653377
   Mead GE, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004366.pub3
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Ministry of Health Labour and Welfare, INF MED CHECK UPS ME
   Nakao M, 2006, B WORLD HEALTH ORGAN, V84, P492, DOI 10.2471/BLT.06.031476
   Nakao M, 2003, J CLIN EPIDEMIOL, V56, P1021, DOI 10.1016/S0895-4356(03)00154-9
   Pan A, 2008, J AFFECT DISORDERS, V109, P75, DOI 10.1016/j.jad.2007.11.002
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Parker G, 2002, AM J PSYCHIAT, V159, P1470, DOI 10.1176/appi.ajp.159.9.1470
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   STEWART JW, 1993, PSYCHIAT CLIN N AM, V16, P479
   Takeuchi T, 2008, SOC PSYCH PSYCH EPID, V43, P343, DOI 10.1007/s00127-008-0306-4
   Takeuchi T, 2009, DIABETES-METAB RES, V25, P762, DOI 10.1002/dmrr.1041
   Vaidya V, 2006, ADV PSYCHOSOM MED, V27, P73, DOI 10.1159/000090965
   Viinamäki H, 2009, ACTA PSYCHIAT SCAND, V120, P23, DOI 10.1111/j.1600-0447.2008.01333.x
   Vogelzangs N, 2007, PSYCHONEUROENDOCRINO, V32, P151, DOI 10.1016/j.psyneuen.2006.11.009
   WEST ED, 1959, BRIT MED J, V1, P1491, DOI 10.1136/bmj.1.5136.1491
   ,, 2008, The global burden of disease: 2004 update
NR 33
TC 32
Z9 34
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1323-1316
EI 1440-1819
J9 PSYCHIAT CLIN NEUROS
JI Psychiatry Clin. Neurosci.
PD NOV
PY 2013
VL 67
IS 7
BP 532
EP 539
DI 10.1111/pcn.12104
PG 8
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 239OA
UT WOS:000326033900009
PM 24152284
OA Bronze
DA 2025-06-11
ER

PT S
AU Shen, J
   Wilmot, KA
   Ghasemzadeh, N
   Molloy, DL
   Burkman, G
   Mekonnen, G
   Gongora, MC
   Quyyumi, AA
   Sperling, LS
AF Shen, Jia
   Wilmot, Kobina A.
   Ghasemzadeh, Nima
   Molloy, Daniel L.
   Burkman, Gregory
   Mekonnen, Girum
   Gongora, Maria C.
   Quyyumi, Arshed A.
   Sperling, Laurence S.
BE Bowman, BA
   Stover, PJ
TI Mediterranean Dietary Patterns and Cardiovascular Health
SO ANNUAL REVIEW OF NUTRITION, VOL 35
SE Annual Review of Nutrition
LA English
DT Review; Book Chapter
DE Mediterranean diet; cardiovascular disease; prevention; health
ID CORONARY-HEART-DISEASE; MODERATE ALCOHOL-CONSUMPTION;
   LOW-DENSITY-LIPOPROTEIN; INTIMA-MEDIA THICKNESS; RED MEAT CONSUMPTION;
   OLIVE OIL; BLOOD-PRESSURE; RISK-FACTORS; ENDOTHELIAL FUNCTION; METABOLIC
   SYNDROME
AB The Mediterranean dietary pattern has been linked with reduced cardiovascular disease incidence and mortality. Components of the Mediterranean diet associated with better cardiovascular health include low consumption of meat and meat products, moderate consumption of ethanol (mostly from wine), and high consumption of vegetables, fruits, nuts, legumes, fish, and olive oil. Increasing evidence indicates that the synergy among these components results in beneficial changes in intermediate pathways of cardiometabolic risk, such as lipids, insulin sensitivity, oxidative stress, inflammation, and vasoreactivity. As a result, consumption of a Mediterranean dietary pattern favorably affects numerous cardiovascular disease risk factors, such as dyslipidemia, hypertension, metabolic syndrome, and diabetes. Moreover, strong evidence links this dietary pattern with reduced cardiovascular disease incidence, reoccurrence, and mortality. This review evaluates the current evidence behind the cardioprotective effects of a Mediterranean dietary pattern.
C1 [Shen, Jia; Wilmot, Kobina A.; Ghasemzadeh, Nima; Mekonnen, Girum; Gongora, Maria C.; Quyyumi, Arshed A.; Sperling, Laurence S.] Emory Univ, Emory Clin Cardiovasc Res Inst, Atlanta, GA 30322 USA.
   [Shen, Jia; Wilmot, Kobina A.; Ghasemzadeh, Nima; Molloy, Daniel L.; Burkman, Gregory; Mekonnen, Girum; Gongora, Maria C.; Quyyumi, Arshed A.; Sperling, Laurence S.] Emory Univ, Dept Med, Div Cardiol, Atlanta, GA 30322 USA.
C3 Emory University; Emory University
RP Shen, J (corresponding author), Emory Univ, Emory Clin Cardiovasc Res Inst, Atlanta, GA 30322 USA.
EM lsperli@emory.edu
FU Abraham J. and Phyllis Katz Foundation Preventive Cardiology Grant
FX The Abraham J. and Phyllis Katz Foundation Preventive Cardiology Grant
   supported this work. The funder had no role in the decision to publish
   the manuscript or in its preparation.
CR Anderson RA, 2001, ATHEROSCLEROSIS, V154, P475, DOI 10.1016/S0021-9150(00)00499-8
   [Anonymous], BMJ D
   Aparicio R., 2013, Handbook of Olive Oil
   AVOLIO AP, 1983, CIRCULATION, V68, P50, DOI 10.1161/01.CIR.68.1.50
   Babio N, 2012, NUTR METAB CARDIOVAS, V22, P200, DOI 10.1016/j.numecd.2010.06.011
   Babio N, 2009, NUTR METAB CARDIOVAS, V19, P563, DOI 10.1016/j.numecd.2008.10.007
   Barnard ND, 2006, DIABETES CARE, V29, P1777, DOI 10.2337/dc06-0606
   Bertoia ML, 2014, AM J CLIN NUTR, V99, P344, DOI 10.3945/ajcn.112.056135
   Blomhoff R, 2006, BRIT J NUTR, V96, pS52, DOI 10.1017/BJN20061864
   Camargo CA, 1997, ARCH INTERN MED, V157, P79, DOI 10.1001/archinte.157.1.79
   Carlsen MH, 2010, NUTR J, V9, DOI 10.1186/1475-2891-9-3
   Ceriello A, 1999, METABOLISM, V48, P1503, DOI 10.1016/S0026-0495(99)90237-8
   Craig WJ, 1999, AM J CLIN NUTR, V70, p491S, DOI 10.1093/ajcn/70.3.491s
   Cuevas AM, 2004, BIOL RES, V37, P225
   Dai J, 2008, AM J CLIN NUTR, V88, P1364, DOI 10.3945/ajcn.2008.26528
   Daviglus ML, 1997, NEW ENGL J MED, V336, P1046, DOI 10.1056/NEJM199704103361502
   de Lorgeril M, 1999, CIRCULATION, V99, P779, DOI 10.1161/01.CIR.99.6.779
   Dehghan M, 2012, CIRCULATION, V126, P2705, DOI 10.1161/CIRCULATIONAHA.112.103234
   Desjardins F, 2006, ACTA CLIN BELG, V61, P326, DOI 10.1179/acb.2006.052
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Dietschy JM, 1998, J NUTR, V128, p444S, DOI 10.1093/jn/128.2.444S
   Dimmitt SB, 1998, BLOOD COAGUL FIBRIN, V9, P39, DOI 10.1097/00001721-199801000-00005
   Doménech M, 2014, HYPERTENSION, V64, P69, DOI 10.1161/HYPERTENSIONAHA.113.03353
   Domingo JL, 2007, TOXICOLOGY, V230, P219, DOI 10.1016/j.tox.2006.11.054
   Eckel RH, 2014, J AM COLL CARDIOL, V63, P2960, DOI 10.1016/j.jacc.2013.11.003
   EHNHOLM C, 1984, ARTERIOSCLEROSIS, V4, P265, DOI 10.1161/01.ATV.4.3.265
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   Esposito K, 2006, PUBLIC HEALTH NUTR, V9, P1073, DOI 10.1017/S1368980007668529
   Estruch R, 2013, NEW ENGL J MED, V368, P1279, DOI 10.1056/NEJMoa1200303
   Estruch R, 2006, ANN INTERN MED, V145, P1, DOI 10.7326/0003-4819-145-1-200607040-00004
   Fagard RH, 2001, MED SCI SPORT EXER, V33, pS484, DOI 10.1097/00005768-200106001-00018
   Fitó M, 2007, ARCH INTERN MED, V167, P1195, DOI 10.1001/archinte.167.11.1195
   Fuentes F, 2001, ANN INTERN MED, V134, P1115, DOI 10.7326/0003-4819-134-12-200106190-00011
   Fung TT, 2009, CIRCULATION, V119, P1093, DOI 10.1161/CIRCULATIONAHA.108.816736
   Gardener H, 2014, ATHEROSCLEROSIS, V234, P303, DOI 10.1016/j.atherosclerosis.2014.03.011
   Gardener H, 2012, ARCH NEUROL-CHICAGO, V69, P251, DOI 10.1001/archneurol.2011.548
   GAZIANO JM, 1993, NEW ENGL J MED, V329, P1829, DOI 10.1056/NEJM199312163292501
   GOLDMAN L, 1984, ANN INTERN MED, V101, P825, DOI 10.7326/0003-4819-101-6-825
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Halcox JPJ, 2002, CIRCULATION, V106, P653, DOI 10.1161/01.CIR.0000025404.78001.D8
   Heitzer T, 2001, CIRCULATION, V104, P2673, DOI 10.1161/hc4601.099485
   Hossain P, 2007, NEW ENGL J MED, V356, P213, DOI 10.1056/NEJMp068177
   Hu FB, 1999, AM J EPIDEMIOL, V149, P531, DOI 10.1093/oxfordjournals.aje.a009849
   Hu FB, 2002, JAMA-J AM MED ASSOC, V287, P1815, DOI 10.1001/jama.287.14.1815
   Huynh NN, 2006, CLIN EXP PHARMACOL P, V33, P1, DOI 10.1111/j.1440-1681.2006.04316.x
   ISO H, 1995, STROKE, V26, P767, DOI 10.1161/01.STR.26.5.767
   Jemai H, 2008, CHEM-BIOL INTERACT, V176, P88, DOI 10.1016/j.cbi.2008.08.014
   Jiang R, 2006, AM J EPIDEMIOL, V163, P222, DOI 10.1093/aje/kwj033
   Kaluza J, 2014, CIRC-HEART FAIL, V7, P552, DOI 10.1161/CIRCHEARTFAILURE.113.000921
   Karatzi K, 2008, J AM COLL NUTR, V27, P448, DOI 10.1080/07315724.2008.10719724
   Kastorini CM, 2012, ANGIOLOGY, V63, P509, DOI 10.1177/0003319711427392
   Kastorini CM, 2011, J AM COLL CARDIOL, V57, P1299
   Kelly JH, 2006, BRIT J NUTR, V96, pS61, DOI 10.1017/BJN20061865
   Keys A, 1980, HEART DIS
   Kleinbongard P, 2006, FREE RADICAL BIO MED, V40, P295, DOI 10.1016/j.freeradbiomed.2005.08.025
   Knoops KTB, 2004, JAMA-J AM MED ASSOC, V292, P1433, DOI 10.1001/jama.292.12.1433
   Kris-Etherton P, 2001, CIRCULATION, V103, P1823, DOI 10.1161/01.CIR.103.13.1823
   Kris-Etherton PM, 2002, CIRCULATION, V106, P2747, DOI 10.1161/01.CIR.0000038493.65177.94
   KROMHOUT D, 1989, AM J CLIN NUTR, V49, P889, DOI 10.1093/ajcn/49.5.889
   Lamarche B, 1997, CIRCULATION, V95, P69, DOI 10.1161/01.CIR.95.1.69
   LANGER RD, 1992, CIRCULATION, V85, P910, DOI 10.1161/01.CIR.85.3.910
   Laurent S, 2001, HYPERTENSION, V37, P1236, DOI 10.1161/01.HYP.37.5.1236
   Leon AS, 2001, MED SCI SPORT EXER, V33, pS502, DOI 10.1097/00005768-200106001-00021
   Li TY, 2009, J NUTR, V139, P1333, DOI 10.3945/jn.108.103622
   Lloyd-Jones DM, 2004, CIRCULATION, V110, P1042, DOI 10.1161/01.CIR.0000140263.20897.42
   Lorenz MW, 2007, CIRCULATION, V115, P459, DOI 10.1161/CIRCULATIONAHA.106.628875
   Machowetz A, 2007, FASEB J, V21, P45, DOI 10.1096/fj.06-6328com
   MARGETTS BM, 1986, BMJ-BRIT MED J, V293, P1468, DOI 10.1136/bmj.293.6560.1468
   Martínez-González MA, 2008, BMJ-BRIT MED J, V336, P1348, DOI 10.1136/bmj.39561.501007.BE
   Martínez-González MA, 2014, CIRCULATION, V130, P18, DOI 10.1161/CIRCULATIONAHA.113.006921
   Martínez-Lapiscina EH, 2013, J NEUROL NEUROSUR PS, V84, P1318, DOI 10.1136/jnnp-2012-304792
   Mattace-Raso FUS, 2006, CIRCULATION, V113, P657, DOI 10.1161/CIRCULATIONAHA.105.555235
   Miles EA, 2005, NUTRITION, V21, P389, DOI 10.1016/j.nut.2004.06.031
   MOORE RD, 1986, MEDICINE, V65, P242, DOI 10.1097/00005792-198607000-00004
   Murie-Fernandez M, 2011, ATHEROSCLEROSIS, V219, P158, DOI 10.1016/j.atherosclerosis.2011.06.050
   Núñez-Córdoba JM, 2009, AM J EPIDEMIOL, V169, P339, DOI 10.1093/aje/kwn335
   Pai JK, 2012, EUR HEART J, V33, P1598, DOI 10.1093/eurheartj/ehs047
   Pan A, 2012, ARCH INTERN MED, V172, P555, DOI 10.1001/archinternmed.2011.2287
   Pan XR, 1997, DIABETES CARE, V20, P537, DOI 10.2337/diacare.20.4.537
   Papamichael CM, 2008, J HYPERTENS, V26, P223, DOI 10.1097/HJH.0b013e3282f25b80
   Pereira EC, 2008, CLIN BIOCHEM, V41, P1454, DOI 10.1016/j.clinbiochem.2008.08.074
   PETRONI A, 1995, THROMB RES, V78, P151, DOI 10.1016/0049-3848(95)00043-7
   Piccini JP, 2012, CIRC-CARDIOVASC QUAL, V5, P85, DOI 10.1161/CIRCOUTCOMES.111.962688
   Pitsavos C, 2005, AM J CLIN NUTR, V82, P694, DOI 10.1093/ajcn/82.3.694
   POWELL KE, 1987, ANNU REV PUBL HEALTH, V8, P253, DOI 10.1146/annurev.publhealth.8.1.253
   Psaltopoulou T, 2004, AM J CLIN NUTR, V80, P1012, DOI 10.1093/ajcn/80.4.1012
   Psaltopoulou T, 2013, ANN NEUROL, V74, P580, DOI 10.1002/ana.23944
   Rajagopalan S, 1996, J CLIN INVEST, V98, P2572, DOI 10.1172/JCI119076
   Rallidis LS, 2009, AM J CLIN NUTR, V90, P263, DOI 10.3945/ajcn.2008.27290
   REAVEN P, 1991, AM J CLIN NUTR, V54, P701, DOI 10.1093/ajcn/54.4.701
   RENAUD S, 1992, LANCET, V339, P1523, DOI 10.1016/0140-6736(92)91277-F
   RENAUD SC, 1992, AM J CLIN NUTR, V55, P1012, DOI 10.1093/ajcn/55.5.1012
   Richard C, 2014, ARTERIOSCL THROM VAS, V34, P433, DOI 10.1161/ATVBAHA.113.302185
   Rimm EB, 1996, BRIT MED J, V312, P731, DOI 10.1136/bmj.312.7033.731
   RIMM EB, 1991, LANCET, V338, P464, DOI 10.1016/0140-6736(91)90542-W
   Rocca AS, 2001, ENDOCRINOLOGY, V142, P1148, DOI 10.1210/en.142.3.1148
   Ros E, 2006, BRIT J NUTR, V96, pS29, DOI 10.1017/BJN20061861
   Ros E, 2014, ADV NUTR, V5, p330S, DOI 10.3945/an.113.005389
   Ros E, 2009, AM J CLIN NUTR, V89, pS1649, DOI 10.3945/ajcn.2009.26736R
   Rossi M, 2013, DIABETOLOGIA, V56, P2405, DOI 10.1007/s00125-013-3013-y
   Ruano J, 2005, J AM COLL CARDIOL, V46, P1864, DOI 10.1016/j.jacc.2005.06.078
   SACKS FM, 1975, NEW ENGL J MED, V292, P1148, DOI 10.1056/NEJM197505292922203
   Sala-Vila A, 2014, ARTERIOSCL THROM VAS, V34, P439, DOI 10.1161/ATVBAHA.113.302327
   Salas-Salvadó J, 2008, ARCH INTERN MED, V168, P2449, DOI 10.1001/archinte.168.22.2449
   Salas-Salvadó J, 2011, DIABETES CARE, V34, P14, DOI 10.2337/dc10-1288
   Salmerón J, 2001, AM J CLIN NUTR, V73, P1019
   Scarmeas N, 2011, ANN NEUROL, V69, P257, DOI 10.1002/ana.22317
   Schulze MB, 2007, ARCH INTERN MED, V167, P956, DOI 10.1001/archinte.167.9.956
   Segura R, 2006, BRIT J NUTR, V96, pS36, DOI 10.1017/BJN20061862
   Sidhu KS, 2003, REGUL TOXICOL PHARM, V38, P336, DOI 10.1016/j.yrtph.2003.07.002
   Simes RJ, 2002, CIRCULATION, V105, P1162, DOI 10.1161/hc1002.105136
   Singh RB, 1997, CARDIOVASC DRUG THER, V11, P485, DOI 10.1023/A:1007757724505
   Singh RB, 2002, LANCET, V360, P1455, DOI 10.1016/S0140-6736(02)11472-3
   Sofi F, 2005, EUR J CLIN NUTR, V59, P584, DOI 10.1038/sj.ejcn.1602112
   Sofi F, 2010, AM J CLIN NUTR, V92, P1189, DOI 10.3945/ajcn.2010.29673
   Sofi F, 2008, BMJ-BRIT MED J, V337, DOI 10.1136/bmj.a1344
   STAMPFER MJ, 1988, NEW ENGL J MED, V319, P267, DOI 10.1056/NEJM198808043190503
   Story M., 2005, NUTR TODAY, V40, P261
   Szeto YT, 2004, NUTRITION, V20, P863, DOI 10.1016/j.nut.2004.06.006
   Mitjavila MT, 2013, CLIN NUTR, V32, P172, DOI 10.1016/j.clnu.2012.08.002
   THOM TJ, 1985, INT J EPIDEMIOL, V14, P510, DOI 10.1093/ije/14.4.510
   Thompson PD, 2003, ARTERIOSCL THROM VAS, V23, pE42, DOI 10.1161/01.ATV.0000089628.63625.D4
   Thompson PD, 2001, MED SCI SPORT EXER, V33, pS438, DOI 10.1097/00005768-200106001-00012
   Toledo E, 2009, BRIT J NUTR, V101, P59, DOI 10.1017/S0007114508981496
   Tortosa A, 2007, DIABETES CARE, V30, P2957, DOI 10.2337/dc07-1231
   Trichopoulou A, 2003, NEW ENGL J MED, V348, P2599, DOI 10.1056/NEJMoa025039
   Tripoli E, 2005, NUTR RES REV, V18, P98, DOI 10.1079/NRR200495
   Valagussa F, 1999, LANCET, V354, P447, DOI 10.1016/S0140-6736(99)07072-5
   van de Laar RJJ, 2013, J INTERN MED, V273, P79, DOI 10.1111/j.1365-2796.2012.02577.x
   VanLeer EM, 1995, INT J EPIDEMIOL, V24, P1117, DOI 10.1093/ije/24.6.1117
   Vincent-Baudry S, 2005, AM J CLIN NUTR, V82, P964, DOI 10.1093/ajcn/82.5.964
   Watson KE, 1997, CIRCULATION, V96, P1755, DOI 10.1161/01.CIR.96.6.1755
   Wengreen H, 2013, AM J CLIN NUTR, V98, P1263, DOI 10.3945/ajcn.112.051276
   WHO, 2003, WHO TECH REP SER, V916, P1
   WILLETT WC, 1995, AM J CLIN NUTR, V61, p1402S, DOI 10.1093/ajcn/61.6.1402S
   WILLETT WC, 1994, SCIENCE, V264, P532, DOI 10.1126/science.8160011
   Wing RR, 2001, ANNU REV NUTR, V21, P323, DOI 10.1146/annurev.nutr.21.1.323
   WOLF PA, 1987, ARCH INTERN MED, V147, P1561, DOI 10.1001/archinte.147.9.1561
   Wu JM, 2001, INT J MOL MED, V8, P3
   Xin X, 2001, HYPERTENSION, V38, P1112, DOI 10.1161/hy1101.093424
   YOUNG SG, 1990, CIRCULATION, V82, P1574, DOI 10.1161/01.CIR.82.5.1574
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
   Zemel MB, 2004, OBES RES, V12, P582, DOI 10.1038/oby.2004.67
   Zemel MB, 2001, J AM COLL NUTR, V20, p428S, DOI 10.1080/07315724.2001.10719180
NR 144
TC 108
Z9 117
U1 0
U2 52
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA
SN 0199-9885
EI 1545-4312
BN 978-0-8243-2835-1
J9 ANNU REV NUTR
JI Annu. Rev. Nutr.
PY 2015
VL 35
BP 425
EP 449
DI 10.1146/annurev-nutr-011215-025104
PG 25
WC Nutrition & Dietetics
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA BD1QC
UT WOS:000358259600014
PM 25974696
OA Bronze
DA 2025-06-11
ER

PT J
AU Gueye, AB
   Pryslawsky, Y
   Trigo, JM
   Poulia, N
   Delis, F
   Antoniou, K
   Loureiro, M
   Laviolette, SR
   Vemuri, K
   Makriyannis, A
   Foll, B
AF Gueye, Aliou B.
   Pryslawsky, Yaroslaw
   Trigo, Jose M.
   Poulia, Nafsika
   Delis, Foteini
   Antoniou, Katerina
   Loureiro, Michael
   Laviolette, Steve R.
   Vemuri, Kiran
   Makriyannis, Alexandros
   Le Foll, Bernard
TI The CB1 Neutral Antagonist AM4113 Retains the Therapeutic
   Efficacy of the Inverse Agonist Rimonabant for Nicotine Dependence and
   Weight Loss with Better Psychiatric Tolerability
SO INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE CB1 antagonism; nicotine reward; dopamine; anxiety; depression
ID FOOD-REINFORCED BEHAVIOR; CARDIOMETABOLIC RISK-FACTORS;
   SUSTAINED-RELEASE BUPROPION; YOHIMBINE-INDUCED INCREASES; CUE-INDUCED
   REINSTATEMENT; RECEPTOR PARTIAL AGONIST; SEEKING BEHAVIOR;
   SMOKING-CESSATION; ALCOHOL-SEEKING; BODY-WEIGHT
AB Background: Multiple studies suggest a pivotal role of the endocannabinoid system in regulating the reinforcing effects of various substances of abuse. Rimonabant, a CB 1 inverse agonist found to be effective for smoking cessation, was associated with an increased risk of anxiety and depression. Here we evaluated the effects of the CB 1 neutral antagonist AM4113 on the abuse-related effects of nicotine and its effects on anxiety and depressive-like behavior in rats.
   Methods: Rats were trained to self-administer nicotine under a fixed-ratio 5 or progressive-ratio schedules of reinforcement. A control group was trained to self-administer food. The acute/chronic effects of AM4113 pretreatment were evaluated on nicotine taking, motivation for nicotine, and cue-, nicotine priming-and yohimbine-induced reinstatement of nicotine-seeking. The effects of AM4113 in the basal firing and bursting activity of midbrain dopamine neurons were evaluated in a separate group of animals treated with nicotine. Anxiety/depression-like effects of AM4113 and rimonabant were evaluated 24 h after chronic (21 days) pretreatment (0, 1, 3, and 10 mg/kg, 1/d).
   Results: AM4113 significantly attenuated nicotine taking, motivation for nicotine, as well as cue-, priming-and stress-induced reinstatement of nicotine-seeking behavior. These effects were accompanied by a decrease of the firing and burst rates in the ventral tegmental area dopamine neurons in response to nicotine. On the other hand, AM4113 pretreatment did not have effects on operant responding for food. Importantly, AM4113 did not have effects on anxiety and showed antidepressant-like effects.
   Conclusion: Our results indicate that AM4113 could be a promising therapeutic option for the prevention of relapse to nicotine-seeking while lacking anxiety/depression-like side effects.
C1 [Gueye, Aliou B.; Pryslawsky, Yaroslaw; Trigo, Jose M.; Le Foll, Bernard] Ctr Addict & Mental Hlth, Translat Addict Res Lab, 33 Russell St, Toronto, ON M5S 2S1, Canada.
   [Le Foll, Bernard] Ctr Addict & Mental Hlth, Alcohol Res & Treatment Clin, Addict Med Serv, Ambulatory Care & Structured Treatments, Toronto, ON, Canada.
   [Le Foll, Bernard] Ctr Addict & Mental Hlth, Campbell Family Mental Hlth Res Inst, Toronto, ON, Canada.
   [Le Foll, Bernard] Univ Toronto, Dept Pharmacol, Dept Family & Community Med, Toronto, ON, Canada.
   [Le Foll, Bernard] Univ Toronto, Dept Psychiat, Div Brain & Therapeut, Toronto, ON, Canada.
   [Le Foll, Bernard] Univ Toronto, Inst Med Sci, Toronto, ON, Canada.
   [Poulia, Nafsika; Delis, Foteini; Antoniou, Katerina] Univ Ioannina, Fac Med, Sch Hlth Sci, Dept Pharmacol, Ioannina, Greece.
   [Loureiro, Michael; Laviolette, Steve R.] Univ Western Ontario, Schulich Sch Med & Dent, Dept Anat & Cell Biol, London, ON, Canada.
   [Vemuri, Kiran; Makriyannis, Alexandros] Northeastern Univ, Ctr Drug Discovery, Dept Pharmaceut Sci, Boston, MA 02115 USA.
   [Vemuri, Kiran; Makriyannis, Alexandros] Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA.
C3 University of Toronto; Centre for Addiction & Mental Health - Canada;
   University of Toronto; Centre for Addiction & Mental Health - Canada;
   University of Toronto; Centre for Addiction & Mental Health - Canada;
   University of Toronto; University of Toronto; University of Toronto;
   University of Ioannina; Western University (University of Western
   Ontario); Northeastern University; Northeastern University
RP Foll, B (corresponding author), Ctr Addict & Mental Hlth, Translat Addict Res Lab, 33 Russell St, Toronto, ON M5S 2S1, Canada.
EM Bernard.LeFoll@camh.ca
RI trigo, jose/C-2770-2011; Antoniou, Katerina/AAB-6062-2022; Makriyannis,
   Alexandros/GRF-1518-2022; Le Foll, Bernard/K-2952-2014
OI Loureiro, Michael/0000-0002-5915-5627; Le Foll,
   Bernard/0000-0002-6406-4973
FU Canadian Institutes of Health Research; NIDA; NIH
FX This work was supported by a grant from the Canadian Institutes of
   Health Research and NIDA, NIH.
CR [Anonymous], SAN AV DISC ALL CLIN
   Beyer CE, 2010, NEUROBIOL DIS, V39, P148, DOI 10.1016/j.nbd.2010.03.020
   Cahill K, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005353.pub4
   Chambers AP, 2007, AM J PHYSIOL-REG I, V293, pR2185, DOI 10.1152/ajpregu.00663.2007
   Chauvet C, 2015, INT J NEUROPSYCHOPH, V18, DOI 10.1093/ijnp/pyu025
   Chiamulera C, 1996, PSYCHOPHARMACOLOGY, V127, P102, DOI 10.1007/BF02805981
   Cluny NL, 2011, PHARMACOL BIOCHEM BE, V97, P537, DOI 10.1016/j.pbb.2010.10.013
   Cohen C, 2002, BEHAV PHARMACOL, V13, P451, DOI 10.1097/00008877-200209000-00018
   Cohen C, 2005, PHARMACOL BIOCHEM BE, V81, P387, DOI 10.1016/j.pbb.2005.01.024
   Cohen C, 2005, NEUROPSYCHOPHARMACOL, V30, P145, DOI 10.1038/sj.npp.1300541
   Cummings K Michael, 2006, Curr Oncol Rep, V8, P475, DOI 10.1007/s11912-006-0077-6
   de Bruin NMWJ, 2011, BEHAV BRAIN RES, V217, P408, DOI 10.1016/j.bbr.2010.11.013
   De Vries TJ, 2005, TRENDS PHARMACOL SCI, V26, P420, DOI 10.1016/j.tips.2005.06.002
   De Vries TJ, 2001, NAT MED, V7, P1151, DOI 10.1038/nm1001-1151
   DOXEY JC, 1984, N-S ARCH PHARMACOL, V325, P136, DOI 10.1007/BF00506193
   Economidou D, 2006, PSYCHOPHARMACOLOGY, V183, P394, DOI 10.1007/s00213-005-0199-9
   Erb S, 2001, PSYCHOPHARMACOLOGY, V158, P360, DOI 10.1007/s002130000642
   Forget B, 2005, PSYCHOPHARMACOLOGY, V181, P722, DOI 10.1007/s00213-005-0015-6
   Forget B, 2010, BIOL PSYCHIAT, V68, P265, DOI 10.1016/j.biopsych.2010.01.029
   Forget B, 2009, PSYCHOPHARMACOLOGY, V205, P613, DOI 10.1007/s00213-009-1569-5
   Gamaleddin I, 2012, ADDICT BIOL, V17, P47, DOI 10.1111/j.1369-1600.2011.00314.x
   Gonzales D, 2006, JAMA-J AM MED ASSOC, V296, P47, DOI 10.1001/jama.296.1.47
   Hashemizadeh S, 2014, PROG NEURO-PSYCHOPH, V51, P65, DOI 10.1016/j.pnpbp.2014.01.010
   Hodge J, 2008, BEHAV BRAIN RES, V193, P298, DOI 10.1016/j.bbr.2008.06.010
   Janero DR, 2009, EXPERT OPIN EMERG DR, V14, P43, DOI [10.1517/14728210902736568 , 10.1517/14728210902736568]
   Jorenby DE, 2006, JAMA-J AM MED ASSOC, V296, P56, DOI 10.1001/jama.296.1.56
   Jutkiewicz EMA, 2010, FASEB J, V24, P581
   Kangas BD, 2013, J PHARMACOL EXP THER, V344, P561, DOI 10.1124/jpet.112.201962
   Khaled MATM, 2010, INT J NEUROPSYCHOPH, V13, P181, DOI 10.1017/S1461145709991064
   Kodas E, 2007, PSYCHOPHARMACOLOGY, V194, P161, DOI 10.1007/s00213-007-0813-0
   Lê AD, 2009, PSYCHOPHARMACOLOGY, V204, P477, DOI 10.1007/s00213-009-1481-z
   Le Foll B, 2005, J PHARMACOL EXP THER, V312, P875, DOI 10.1124/jpet.104.077974
   Le Foll B, 2004, NEUROREPORT, V15, P2139, DOI 10.1097/00001756-200409150-00028
   Le Foll B, 2014, PROG NEURO-PSYCHOPH, V52, P86, DOI 10.1016/j.pnpbp.2013.10.009
   Lerman C, 2007, NAT REV DRUG DISCOV, V6, P746, DOI 10.1038/nrd2361
   Liu X, 2007, NEUROPSYCHOPHARMACOL, V32, P710, DOI 10.1038/sj.npp.1301129
   Lupica CR, 2005, NEUROPHARMACOLOGY, V48, P1105, DOI 10.1016/j.neuropharm.2005.03.016
   Maldonado R, 2006, TRENDS NEUROSCI, V29, P225, DOI 10.1016/j.tins.2006.01.008
   Marinelli PW, 2007, PSYCHOPHARMACOLOGY, V195, P345, DOI 10.1007/s00213-007-0905-x
   Mastinu A, 2013, PHARMACOL RES, V74, P94, DOI 10.1016/j.phrs.2013.06.001
   Mastinu A, 2012, BEHAV BRAIN RES, V234, P192, DOI 10.1016/j.bbr.2012.06.033
   Merritt LL, 2008, J PHARMACOL EXP THER, V326, P483, DOI 10.1124/jpet.108.138321
   Meye FJ, 2013, MOL PSYCHIATR, V18, P1294, DOI 10.1038/mp.2012.145
   O'Brien LD, 2013, PHARMACOL BIOCHEM BE, V103, P597, DOI 10.1016/j.pbb.2012.10.008
   Padwal RS, 2007, LANCET, V369, P71, DOI 10.1016/S0140-6736(07)60033-6
   Pi-Sunyer F, 2006, JAMA-J AM MED ASSOC, V295, P761, DOI 10.1001/jama.295.7.761
   ROBERTS DCS, 1993, PSYCHOPHARMACOLOGY, V111, P215, DOI 10.1007/BF02245526
   SCATTON B, 1980, J PHARMACOL EXP THER, V215, P494
   Shoaib M, 2008, NEUROPHARMACOLOGY, V54, P438, DOI 10.1016/j.neuropharm.2007.10.011
   Shoaib M, 2006, PSYCHOPHARMACOLOGY, V188, P252, DOI 10.1007/s00213-006-0498-9
   Sink KS, 2010, EUR NEUROPSYCHOPHARM, V20, P112, DOI 10.1016/j.euroneuro.2009.11.002
   Sink KS, 2009, PSYCHOPHARMACOLOGY, V206, P223, DOI 10.1007/s00213-009-1602-8
   Sink KS, 2009, PHARMACOL BIOCHEM BE, V91, P303, DOI 10.1016/j.pbb.2008.07.013
   Sink KS, 2008, NEUROPSYCHOPHARMACOL, V33, P946, DOI 10.1038/sj.npp.1301476
   Tan HB, 2009, NEUROPHARMACOLOGY, V56, P741, DOI 10.1016/j.neuropharm.2008.12.008
   Van Gaal LF, 2008, EUR HEART J, V29, P1761, DOI 10.1093/eurheartj/ehn076
   WINTER JC, 1992, J PHARMACOL EXP THER, V263, P682
NR 57
TC 57
Z9 62
U1 0
U2 8
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1461-1457
EI 1469-5111
J9 INT J NEUROPSYCHOPH
JI Int. J. Neuropsychopharmacol.
PD DEC
PY 2016
VL 19
IS 12
DI 10.1093/ijnp/pyw068
PG 11
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA EK4QV
UT WOS:000393912800002
PM 27493155
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Bekyarova, G
   Kiselova-Kaneva, Y
   Madjov, V
   Gerova, D
   Bekyarov, N
   Todorova, M
   Stoeva, S
AF Bekyarova, Ganka
   Kiselova-Kaneva, Yoana
   Madjov, Valentina
   Gerova, Daniela
   Bekyarov, Nicolay
   Todorova, Monica
   Stoeva, Stefka
TI The predictable role37 of adma and oxidative stress in endothelial
   dysfunction-a pilot study
SO JOURNAL OF IMAB
LA English
DT Article; Proceedings Paper
CT 13th South-East European Conference of Chemotherapy, Infections and
   Cancer and 33rd Annual Assembly of
   International-Medical-Association-Bulgaria (SEEC/IMAB)
CY OCT 12-15, 2023
CL Belgrade, SERBIA
SP Int Med Assoc Bulgaria
DE ADMA; oxidative stress; endothelial dysfunction; metabolic syndrome
ID ASYMMETRIC DIMETHYLARGININE ADMA; BIOLOGY
AB The aim of the study was to examine the plasma levels ADMA, MDA and lipid markers in people with metabolic syndrome as well as in clinically asymptomatic people. We further studied whether such elevation of ADMA as marker of endothelial dysfunction was correlated with oxidative stress and conventional risk factors.
   According to modified ATP III criteria the participants (52 females, 8 males) of the study were divided in four group: G1, n=19 people with MetS; G2, n=12 peoples with genetic predisposition and risk for MetS; G3, n=15 people with unhealthy life style and risk of MetS and Control group n=14). The study revealed significant differences between people groups with and without anamnestic data of MetS in terms of ADMA, MDA and lipid markers. Plasma levels of ADMA and MDA in G1 were significantly higher (p<0.001) compared to these of G3. The levels of lipid markers (TG, TChol and LDL-C, HDL-C) in G1 were close to the control. The levels of ADMA significantly correlated with plasma MDA levels. These results suggest a link between plasma ADMA and MDA as indicator of oxidative stress and their role as predictive biomarkers for of endothelial dysfunction and cardiometabolic risk.
C1 [Bekyarova, Ganka; Madjov, Valentina; Gerova, Daniela; Bekyarov, Nicolay; Todorova, Monica] Univ Prof Paraskev Stoyanov, Med Fac, Varna, Bulgaria.
   [Kiselova-Kaneva, Yoana; Stoeva, Stefka] Univ Prof Paraskev Stoyanov, Fac Pharm, Varna, Bulgaria.
C3 Medical University Varna
RP Bekyarova, G (corresponding author), Univ Prof Paraskev Stoyanov, Med Fac, Varna, Bulgaria.
CR Bekyarova G, 2007, Folia Medica, P13, DOI [10.1515/CCLM.2003.225, DOI 10.1515/CCLM.2003.225]
   Böger RH, 2003, CLIN CHEM LAB MED, V41, P1467, DOI 10.1515/CCLM.2003.225
   Bouras G, 2013, CURR TOP MED CHEM, V13, P180, DOI 10.2174/1568026611313020007
   Chen AF, 2012, CLIN SCI, V123, P73, DOI 10.1042/CS20110562
   Cooke JP, 2005, VASC MED, V10, pS11, DOI 10.1191/1358863x05vm598oa
   Ferlazzo N, 2021, CURR ISSUES MOL BIOL, V43, P704, DOI 10.3390/cimb43020051
   Ito A, 1999, CIRCULATION, V99, P3092, DOI 10.1161/01.CIR.99.24.3092
   Palomo I, 2011, NITRIC OXIDE-BIOL CH, V24, P224, DOI 10.1016/j.niox.2011.03.002
   Pope AJ, 2009, J BIOL CHEM, V284, P35338, DOI 10.1074/jbc.M109.037036
   Sydow K, 2003, ATHEROSCLEROSIS SUPP, V4, P41, DOI 10.1016/S1567-5688(03)00033-3
   Vallance P, 2004, ARTERIOSCL THROM VAS, V24, P1023, DOI 10.1161/01.ATV.0000128897.54893.26
NR 11
TC 0
Z9 0
U1 1
U2 2
PU Peytchinski Publishing Ltd
PI PLEVEN
PA compl. Droujba bl. 116, ap. 41, PLEVEN, BULGARIA
SN 1312-773X
J9 J IMAB
JI J. IMAB
PY 2022
VL 22
SU 1
BP 38
EP 41
PG 4
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA GP1J8
UT WOS:001153778000011
DA 2025-06-11
ER

PT J
AU Cen, MQ
   Song, LL
   Fu, XH
   Gao, XX
   Zuo, QL
   Wu, J
AF Cen, Manqiu
   Song, Lingling
   Fu, Xihang
   Gao, Xinxin
   Zuo, Qianlin
   Wu, Jing
TI Associations between metabolic syndrome and anxiety, and the mediating
   role of inflammation: Findings from the UK Biobank
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Metabolic syndrome; Anxiety; Inflammation; UK Biobank
ID LOW-GRADE INFLAMMATION; BLOOD-CELL COUNT; STRATIFIED ANALYSIS;
   LIFE-STYLE; DEPRESSION; WHITE; DISORDERS; SYMPTOMS; SYSTEMS; STRESS
AB Objectives: To investigate the association between metabolic syndrome (MetS) and anxiety and to explore the mediating role of inflammation indicators in this relationship based on the UK Biobank prospective cohort. Methods: This population-based retrospective cohort study analyzed data from 308,352 participants. MetS was defined according to criteria jointly developed by the American Heart Association, the National Heart, Lung, and Blood Institute, and the International Diabetes Federation. Anxiety was defined using ICD-10 codes. Cox proportional risk regression models were used to explore the hazard ratios (HRs) between MetS, components of MetS, number of MetS components, and anxiety. The mediating effect of inflammation on the association between MetS and anxiety was explored using longitudinal mediation analysis. Results: A total of 308,352 participants were included in this study. Of these, 9471 (3.071 %) developed anxiety over a mean follow-up of 12.05 years. In the fully adjusted model, MetS increased the risk of anxiety by 13.6 % (HR: 1.136, 95 %CI: 1.085-1.189). All MetS components significantly increased the risk of anxiety, with HRs ranging from 1.066 to 1.165. When MetS was treated as a linear variable, the risk of anxiety increased by 6.5 % per component increment. Age-stratified results showed that the risk of MetS for anxiety was higher among those <55 years (HR: 1.23, 95 %CI: 1.13-1.33) than among those >= 55 years (HR: 1.12, 95 %CI: 1.06-1.18). The mediating effects of platelets, lymphocytes, neutrophils, C-reactive protein, leukocytes, and INFLA scores on the association between MetS and anxiety were significant, with mediating effects of 2.30 %, 7.20 %, 15.9 %, 20.7 %, 22.0 %, and 25.3 %, respectively, and a combined mediating effect of these inflammatory factors was 30.8 % (except for INFLA scores). Conclusions: MetS and its components significantly increased the risk of anxiety, which increased with the number of components. This association may be partially mediated by serum inflammatory indicators, suggesting that MetS may increase the risk of anxiety by elevating the level of chronic inflammation.
C1 [Cen, Manqiu; Song, Lingling; Fu, Xihang; Gao, Xinxin; Zuo, Qianlin; Wu, Jing] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan 430030, Peoples R China.
   [Cen, Manqiu; Song, Lingling; Fu, Xihang; Gao, Xinxin; Zuo, Qianlin; Wu, Jing] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Minist Educ Key Lab Environm & Hlth, Wuhan 430030, Peoples R China.
   [Cen, Manqiu; Song, Lingling; Fu, Xihang; Gao, Xinxin; Zuo, Qianlin; Wu, Jing] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth Incubating, Wuhan 430030, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology
RP Wu, J (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan 430030, Peoples R China.
EM wujingtj@hust.edu.cn
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Baxter AJ, 2013, PSYCHOL MED, V43, P897, DOI 10.1017/S003329171200147X
   Berto LF, 2022, J ACAD CONSULT-LIAIS, V63, P529, DOI 10.1016/j.jaclp.2022.06.001
   BJORNTORP P, 1995, METABOLISM, V44, P21, DOI 10.1016/0026-0495(95)90315-1
   Bonaccio M, 2016, HAEMATOLOGICA, V101, P1434, DOI 10.3324/haematol.2016.144055
   Butnoriene J, 2018, BMC PSYCHIATRY, V18, DOI 10.1186/s12888-017-1576-8
   Chan KL, 2019, PHYSIOLOGY, V34, P123, DOI 10.1152/physiol.00047.2018
   Chu KQ, 2023, BRAIN BEHAV IMMUN, V108, P233, DOI 10.1016/j.bbi.2022.11.016
   Craske MG, 2016, LANCET, V388, P3048, DOI 10.1016/S0140-6736(16)30381-6
   Dortland AKBV, 2013, PSYCHONEUROENDOCRINO, V38, P209, DOI 10.1016/j.psyneuen.2012.05.017
   Duivis HE, 2013, PSYCHONEUROENDOCRINO, V38, P1573, DOI 10.1016/j.psyneuen.2013.01.002
   Eren I, 2003, PSYCHIAT RES-NEUROIM, V123, P135, DOI 10.1016/S0925-4927(03)00062-3
   Erichsen JM, 2022, NEUROPHARMACOLOGY, V203, DOI 10.1016/j.neuropharm.2021.108877
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Ferrari AJ, 2022, LANCET PSYCHIAT, V9, P137, DOI 10.1016/S2215-0366(21)00395-3
   Fry A, 2017, AM J EPIDEMIOL, V186, P1026, DOI 10.1093/aje/kwx246
   Gialluisi A, 2020, BRAIN BEHAV IMMUN, V85, P4, DOI 10.1016/j.bbi.2019.04.041
   Goldsmith DR, 2023, BIOL PSYCHIAT, V93, P405, DOI 10.1016/j.biopsych.2022.11.003
   Guo BQ, 2023, TRANSL PSYCHIAT, V13, DOI 10.1038/s41398-022-02297-y
   Hedayati MT, 2021, CASP J INTERN MED, V12, P59, DOI 10.22088/cjim.12.1.59
   Ji S, 2023, FRONT PSYCHIATRY, V14, DOI 10.3389/fpsyt.2023.1118836
   Lemche AV, 2016, PSYCHOPHYSIOLOGY, V53, P914, DOI 10.1111/psyp.12623
   Madva EN, 2018, PSYCHOL HEALTH MED, V23, P555, DOI 10.1080/13548506.2017.1384554
   Marsland AL, 2010, METABOLISM, V59, P1801, DOI 10.1016/j.metabol.2010.05.015
   Moazzami K, 2019, HEALTH PSYCHOL, V38, P586, DOI 10.1037/hea0000764
   Monroy-Iglesias MJ, 2021, INT J CANCER, V148, P825, DOI 10.1002/ijc.33255
   Moreira FP, 2019, BRAZ J PSYCHIAT, V41, P38, DOI 10.1590/1516-4446-2017-2328
   Najafi K., 2022, Int. J. Africa Nursing Sci., V17
   Okosun IS, 2013, DIABETES METAB SYND, V7, P154, DOI 10.1016/j.dsx.2013.06.007
   Osimo EF, 2020, BRAIN BEHAV IMMUN, V87, P901, DOI 10.1016/j.bbi.2020.02.010
   Pan CY, 2022, PSYCHIAT RES, V311, DOI 10.1016/j.psychres.2022.114488
   Pedersen K.M., 2018, Blood, V132
   Pounis G, 2016, THROMB HAEMOSTASIS, V115, P344, DOI 10.1160/TH15-06-0487
   Reagan LP, 2021, NEUROBIOL STRESS, V15, DOI 10.1016/j.ynstr.2021.100354
   Renna ME, 2018, DEPRESS ANXIETY, V35, P1081, DOI 10.1002/da.22790
   Ressler KJ, 2000, DEPRESS ANXIETY, V12, P2, DOI 10.1002/1520-6394(2000)12:1+<2::AID-DA2>3.3.CO;2-W
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Salim S, 2012, ADV PROTEIN CHEM STR, V88, P1, DOI 10.1016/B978-0-12-398314-5.00001-5
   Schmidt MI, 2003, CLIN CHEM LAB MED, V41, P1120, DOI 10.1515/CCLM.2003.174
   Shafiee M, 2017, PSYCHONEUROENDOCRINO, V84, P101, DOI 10.1016/j.psyneuen.2017.06.021
   Shang J, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0093432
   Shi HQ, 2022, BRAIN BEHAV IMMUN, V106, P100, DOI 10.1016/j.bbi.2022.07.165
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Smiley A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112582
   Takeuchi T, 2009, DIABETES-METAB RES, V25, P762, DOI 10.1002/dmrr.1041
   Tayefi M, 2017, PSYCHONEUROENDOCRINO, V81, P63, DOI 10.1016/j.psyneuen.2017.02.035
   Vishram JKK, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0107294
   Wang B, 2022, NEUROLOGY, V99, pE2336, DOI 10.1212/WNL.0000000000201231
   Won E, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21186546
   Yuan N, 2019, TRANSL PSYCHIAT, V9, DOI 10.1038/s41398-019-0570-y
NR 50
TC 28
Z9 29
U1 11
U2 29
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD FEB
PY 2024
VL 116
BP 1
EP 9
DI 10.1016/j.bbi.2023.11.019
EA NOV 2023
PG 9
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA CU5Z2
UT WOS:001127776800001
PM 37984624
DA 2025-06-11
ER

PT J
AU Vargas, HO
   Nunes, SOV
   de Castro, MP
   Bortolasci, CC
   Barbosa, DS
   Morimoto, HK
   Venugopal, K
   Dodd, S
   Maes, M
   Berk, M
AF Vargas, Heber Odebrecht
   Vargas Nunes, Sandra Odebrecht
   de Castro, Marcia Pizzo
   Bortolasci, Chiara Cristina
   Barbosa, Decio Sabbatini
   Morimoto, Helena Kaminami
   Venugopal, Kamalesh
   Dodd, Seetal
   Maes, Michael
   Berk, Michael
TI Oxidative stress and lowered total antioxidant status are associated
   with a history of suicide attempts
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Suicide; Oxidative stress; Inflammation; Metabolism; Depressive
   disorders; Nicotine dependence
ID C-REACTIVE PROTEIN; CIGARETTE-SMOKING; METABOLIC SYNDROME; DEPRESSIVE
   DISORDER; MAJOR DEPRESSION; INFLAMMATION; HEALTH; RISK; CHOLESTEROL;
   CYTOKINES
AB Background: There is evidence that depression is accompanied by inflammation, oxidative and nitrosative stress (O&NS) and metabolic disorders. However links between oxidative stress and suicide attempts in depressed patients are poorly understood. This study examines whether a history of suicide attempts is associated with inflammation, O&NS and metabolic disorders.
   Methods: Blood specimens were collected from study participants aged 18-60 (N=342) recruited at the State University of Londrina, Brazil, and measured for oxidative stress biomarkers: nitric oxide metabolites (NOx), lipid hydroperoxides, malondialdehyde, advanced oxidation protein products and plasma total antioxidant potential (TRAP); inflammatory biomarkers: fibrinogen, high sensitivity C-reactive protein, erythrocyte sedimentation rate, interleukin-6 and tumor necrosis factor-alpha; and metabolic variables. Subjects were divided into those with (n=141) and without (n=201) a history of suicidal attempts.
   Results: Individuals with a history of suicide attempts had significantly higher levels of NOx and lipid hydroperoxides and lowered TRAP as compared to individuals without suicide attempts. There were no significant associations between a history of suicide attempts and inflammatory and metabolic biomarkers and metabolic syndrome. Logistic regression showed that both unipolar and bipolar disorder, female gender, smoking behavior and lipid hydroperoxides were significantly associated with a history of suicide attempts. The combined effects of oxidative stress, smoking, depression, female gender were independent from classical risk factors, including marital status, years of education and anxiety.
   Conclusions: O&NS as well as lowered antioxidant levels may play a role in the pathophysiology of suicidal behavior independently from the effects of depression and smoking, both of which are associated with increased O&NS, and classical suicide predictors, such as years of education and marital status. (C) 2013 Published by Elsevier B.V.
C1 [Vargas, Heber Odebrecht; Vargas Nunes, Sandra Odebrecht] Univ Estadual Londrina, Dept Clin Med, Psychiat Unit, BR-86051990 Londrina, Brazil.
   [Vargas, Heber Odebrecht; Vargas Nunes, Sandra Odebrecht; de Castro, Marcia Pizzo; Bortolasci, Chiara Cristina] Ctr Approach & Treatment Smokers, Londrina, Parana, Brazil.
   [Barbosa, Decio Sabbatini; Morimoto, Helena Kaminami] Univ Estadual Londrina, Dept Clin Anal & Toxicol, BR-86051990 Londrina, Parana, Brazil.
   [Dodd, Seetal; Berk, Michael] Univ Melbourne, Dept Psychiat, Parkville, Vic 3052, Australia.
   [Venugopal, Kamalesh; Dodd, Seetal; Maes, Michael; Berk, Michael] Deakin Univ, Sch Med, Geelong, Vic 3217, Australia.
   [Berk, Michael] Univ Melbourne, Orygen Youth Hlth Res Ctr, Ctr Youth Mental Hlth, Parkville, Vic 3052, Australia.
   [Dodd, Seetal; Berk, Michael] Swanston Ctr, Barwon Hlth & Geelong Clin, Geelong, Vic 3220, Australia.
   [Berk, Michael] Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   University of Melbourne; Deakin University; Orygen, The National Centre
   of Excellence in Youth Mental Health; University of Melbourne; Florey
   Institute of Neuroscience & Mental Health
RP Vargas, HO (corresponding author), Univ Estadual Londrina, Dept Clin Med, Psychiat Unit, Rodovia Celso Garcia Cid 445,KM 380,Campus Univ, BR-86051990 Londrina, Brazil.
EM hebervargas@sercomtel.com.br
RI Nunes, Sandra/B-4035-2019; Barbosa, Décio/AAE-6351-2019; Maes,
   Michael/B-8546-2011; Venugopal, Kamalesh/NJT-2319-2025; Berk,
   Michael/AGH-9427-2022; Bortolasci, Chiara/C-7336-2016; Berk,
   Michael/M-7891-2013
OI Bortolasci, Chiara/0000-0002-0794-6363; Venugopal,
   Kamalesh/0000-0002-5611-6489; Dodd, Seetal/0000-0002-7918-4636; Maes,
   Michael/0000-0002-2012-871X; Berk, Michael/0000-0002-5554-6946
FU Londrina State University, Parana, Brazil (UEL); Brazilian Federal
   Agency for Support and Evaluation of Graduate Education (CAPES);
   Ministry for Science and Technology of Brazil (CNPq)
FX This study was supported by Health Sciences Postgraduate Program at
   Londrina State University, Parana, Brazil (UEL), Brazilian Federal
   Agency for Support and Evaluation of Graduate Education (CAPES) and
   Ministry for Science and Technology of Brazil (CNPq).
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Ali R, 2002, ADDICTION, V97, P1183
   Almeida OP, 2007, PSYCHOL MED, V37, P1775, DOI 10.1017/S0033291707000827
   [Anonymous], MOL PSYCHIAT
   Bergquist J, 2002, EUR NEUROPSYCHOPHARM, V12, P153, DOI 10.1016/S0924-977X(02)00002-0
   Berk M, 2011, NEUROSCI BIOBEHAV R, V35, P804, DOI 10.1016/j.neubiorev.2010.10.001
   Breslau N, 2005, ARCH GEN PSYCHIAT, V62, P328, DOI 10.1001/archpsyc.62.3.328
   Bronisch T, 2008, J AFFECT DISORDERS, V108, P135, DOI 10.1016/j.jad.2007.10.010
   Burke A, 2003, PROG CARDIOVASC DIS, V46, P79, DOI 10.1016/S0033-0620(03)00076-8
   Capuron L, 2008, BIOL PSYCHIAT, V64, P896, DOI 10.1016/j.biopsych.2008.05.019
   Chen CC, 2008, METABOLISM, V57, P544, DOI 10.1016/j.metabol.2007.11.018
   Danner M, 2003, PSYCHOSOM MED, V65, P347, DOI 10.1097/01.PSY.0000041542.29808.01
   Del-Ben Cristina Marta, 2001, Revista Brasileira de Psiquiatria, V23, P156, DOI 10.1590/S1516-44462001000300008
   Elovainio M, 2009, PSYCHOSOM MED, V71, P423, DOI 10.1097/PSY.0b013e31819e333a
   FACCHINI FS, 1992, LANCET, V339, P1128, DOI 10.1016/0140-6736(92)90730-Q
   Fiedorowicz JG, 2007, PSYCHIAT RES, V152, P11, DOI 10.1016/j.psychres.2006.09.003
   Foley DL, 2010, TWIN RES HUM GENET, V13, P347, DOI 10.1375/twin.13.4.347
   Ford DE, 2004, ARCH INTERN MED, V164, P1010, DOI 10.1001/archinte.164.9.1010
   Forlenza MJ, 2006, PSYCHOSOM MED, V68, P1, DOI 10.1097/01.psy.0000195780.37277.2a
   Goodwin RD, 2013, J AFFECT DISORDERS, V145, P111, DOI 10.1016/j.jad.2012.05.003
   Hamer M, 2009, BRAIN BEHAV IMMUN, V23, P413, DOI 10.1016/j.bbi.2009.01.005
   Hughes JR, 2008, DRUG ALCOHOL DEPEN, V98, P169, DOI 10.1016/j.drugalcdep.2008.06.003
   Jentzsch AM, 1996, FREE RADICAL BIO MED, V20, P251, DOI 10.1016/0891-5849(95)02043-8
   JIANG ZY, 1991, LIPIDS, V26, P853, DOI 10.1007/BF02536169
   Kim YK, 2004, J AFFECT DISORDERS, V81, P161, DOI 10.1016/S0165-0327(03)00166-6
   Kim YK, 2008, PROG NEURO-PSYCHOPH, V32, P356, DOI 10.1016/j.pnpbp.2007.08.041
   Kozumplik O, 2011, PSYCHIAT DANUB, V23, P84
   Lasser K, 2000, JAMA-J AM MED ASSOC, V284, P2606, DOI 10.1001/jama.284.20.2606
   Lear SA, 2010, EUR J CLIN NUTR, V64, P42, DOI 10.1038/ejcn.2009.70
   Leonard B, 2012, NEUROSCI BIOBEHAV R, V36, P764, DOI 10.1016/j.neubiorev.2011.12.005
   LESTER D, 1993, J AFFECT DISORDERS, V27, P117, DOI 10.1016/0165-0327(93)90084-W
   Li YF, 2007, NUTR NEUROSCI, V10, P51, DOI 10.1080/10284150701250747
   Liukkonen T, 2006, BIOL PSYCHIAT, V60, P825, DOI 10.1016/j.biopsych.2006.02.016
   Maes M, 1996, SCHIZOPHR RES, V21, P39, DOI 10.1016/0920-9964(96)00029-1
   Maes M, 1997, ACTA PSYCHIAT SCAND, V95, P212, DOI 10.1111/j.1600-0447.1997.tb09622.x
   Maes M, 2011, PROG NEURO-PSYCHOPH, V35, P676, DOI 10.1016/j.pnpbp.2010.05.004
   Malone KM, 2003, AM J PSYCHIAT, V160, P773, DOI 10.1176/appi.ajp.160.4.773
   McGee R, 2005, AM J PSYCHIAT, V162, P619, DOI 10.1176/appi.ajp.162.3.619
   Mendlovic S, 1999, IMMUNOL LETT, V67, P105, DOI 10.1016/S0165-2478(98)00145-X
   Miller AH, 2009, BIOL PSYCHIAT, V65, P732, DOI 10.1016/j.biopsych.2008.11.029
   NASSBERGER L, 1993, ACTA PSYCHIAT SCAND, V88, P48, DOI 10.1111/j.1600-0447.1993.tb03412.x
   Navarro-Gonzálvez JA, 1998, CLIN CHEM, V44, P679
   Pasco JA, 2008, BRIT J PSYCHIAT, V193, P322, DOI 10.1192/bjp.bp.107.046706
   Rabe-Jablonska J, 2000, Med Sci Monit, V6, P539
   Raison CL, 2006, TRENDS IMMUNOL, V27, P24, DOI 10.1016/j.it.2005.11.006
   Repetto M, 1996, CLIN CHIM ACTA, V255, P107, DOI 10.1016/0009-8981(96)06394-2
   Rytilä P, 2006, RESP RES, V7, DOI 10.1186/1465-9921-7-69
   Sansone Randy A, 2008, Psychiatry (Edgmont), V5, P22
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Sublette ME, 2011, BRAIN BEHAV IMMUN, V25, P1272, DOI 10.1016/j.bbi.2011.05.002
   Talarowska M, 2012, NEUROSCI LETT, V510, P127, DOI 10.1016/j.neulet.2012.01.018
   Underwood MD, 2011, BIOL PSYCHIAT, V70, P306, DOI 10.1016/j.biopsych.2011.06.004
   Nunes SOV, 2012, NICOTINE TOB RES, V14, P540, DOI 10.1093/ntr/ntr247
   Williams LJ, 2009, J AFFECT DISORDERS, V118, P173, DOI 10.1016/j.jad.2009.02.001
   WitkoSarsat V, 1996, KIDNEY INT, V49, P1304, DOI 10.1038/ki.1996.186
NR 56
TC 112
Z9 116
U1 0
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD SEP 25
PY 2013
VL 150
IS 3
BP 923
EP 930
DI 10.1016/j.jad.2013.05.016
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 213ER
UT WOS:000324038000030
PM 23856278
DA 2025-06-11
ER

PT J
AU Foley, DL
   Morley, KI
   Madden, PAF
   Heath, AC
   Whitfield, JB
   Martin, NG
AF Foley, Debra L.
   Morley, Katherine I.
   Madden, Pamela A. F.
   Heath, Andrew C.
   Whitfield, John B.
   Martin, Nicholas G.
TI Major Depression and the Metabolic Syndrome
SO TWIN RESEARCH AND HUMAN GENETICS
LA English
DT Article
DE depressive disorder; major; metabolic syndrome; cardiovascular diseases
ID MIDDLE-AGED MEN; ENVIRONMENTAL-CONTRIBUTIONS; YOUNG-ADULTS; TWIN SAMPLE;
   SYMPTOMS; HEALTH; RISK; WOMEN; CHOLESTEROL; DEPENDENCE
AB T he aim of this study is to characterize the relation! ship between major depression and the metabolic syndrome in a large community based sample of Australian men and women aged 26-90 years. A lifetime history of major depression was assessed by telephone interview following the DSM-III-R. A current history of metabolic syndrome was assessed following the United States National Cholesterol Education Program Adult Treatment Panel Ill (NCEP AP-III) guidelines 1 to 3 years later. Logistic regression was used to estimate the association between depression and the metabolic syndrome, and its component criteria, controlling for age, sex and alcohol dependence. There was no association between a lifetime history of major depression and the presence of the metabolic syndrome. There was a weak association between depression and low high-density lipoprotein cholesterol but not with other component criteria of the metabolic syndrome. Despite calls for interventions directed at depression to reduce the onset of the metabolic syndrome there are important failures to replicate in large samples such as this, no consensus regarding the threshold at which depression may pose a significant risk even allowing for heterogeneity across populations, and no consensus regarding confounders that may explain inter-study differences. The absence of any dosage effect of depression on the associated risk for the metabolic syndrome in other unselected samples does not support a direct causal relationship. The call for intervention studies on the basis of the currently published evidence base is unwarranted.
C1 [Foley, Debra L.] Univ Melbourne, Orygen Youth Hlth Res Ctr, Biostat Unit, Parkville, Vic 3052, Australia.
   [Foley, Debra L.] Univ Melbourne, Ctr Youth Mental Hlth, Parkville, Vic 3052, Australia.
   [Morley, Katherine I.] Wellcome Trust Sanger Inst, Cambridge, England.
   [Morley, Katherine I.] Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Sch Populat Hlth, Parkville, Vic 3052, Australia.
   [Madden, Pamela A. F.; Heath, Andrew C.] Washington Univ, Dept Psychiat, Sch Med, St Louis, MO 63130 USA.
   [Whitfield, John B.; Martin, Nicholas G.] Queensland Inst Med Res, Genet & Mol Epidemiol Labs, Brisbane, Qld 4006, Australia.
C3 University of Melbourne; Orygen, The National Centre of Excellence in
   Youth Mental Health; Orygen, The National Centre of Excellence in Youth
   Mental Health; University of Melbourne; Wellcome Trust Sanger Institute;
   University of Melbourne; Washington University (WUSTL); QIMR Berghofer
   Medical Research Institute
RP Foley, DL (corresponding author), Univ Melbourne, Orygen Youth Hlth Res Ctr, Biostat Unit, 35 Poplar Rd, Parkville, Vic 3052, Australia.
EM dfoley@unimelb.edu.au
RI Martin, Nicholas/R-9235-2019; Morley, Katherine/A-2986-2011
OI Morley, Katherine/0000-0002-2725-5535; Martin,
   Nicholas/0000-0003-4069-8020; Whitfield, John/0000-0002-1103-0876
FU American National Institute of Health [AA07535, AA13320, AA13326,
   AA014041]; Australian National Health and Medical Research Council
   [520452, 628911]; Colonial Foundation (Australia); Heart Foundation
   (Australia) [G09M4402]
FX American National Institute of Health grants have supported this work,
   including grants to Drs Andrew Heath (AA07535, AA13320), Nick Martin
   (AA13326), and John Whitfield (AA014041). Dr Katherine Morley is
   supported by a Public Health Fellowship from the Australian National
   Health and Medical Research Council (520452). Dr Debra Foley is
   supported by the Colonial Foundation (Australia) and the Heart
   Foundation (Australia) (G09M4402). We also acknowledge the Australian
   Twin Registry for ascertainment of twin subjects. The Australian Twin
   Registry is supported by enabling grant 628911 from the Australian
   National Health and Medical Research Council and administered by The
   University of Melbourne.
CR Bierut LJ, 1999, ARCH GEN PSYCHIAT, V56, P557, DOI 10.1001/archpsyc.56.6.557
   Bigaard J, 2003, OBES RES, V11, P895, DOI 10.1038/oby.2003.123
   Brunner J, 2002, PHARMACOPSYCHIATRY, V35, P1, DOI 10.1055/s-2002-19834
   Cameron AJ, 2008, J INTERN MED, V264, P177, DOI 10.1111/j.1365-2796.2008.01935.x
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   Gil Katarzyna, 2006, Kardiol Pol, V64, P464
   Glassman A, 2008, PHARMACOPSYCHIATRY, V41, P221, DOI 10.1055/s-2008-1058108
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Hansell NK, 2008, TWIN RES HUM GENET, V11, P287, DOI 10.1375/twin.11.3.287
   Heath AC, 1997, PSYCHOL MED, V27, P1381, DOI 10.1017/S0033291797005643
   Heiskanen TH, 2006, J CLIN PSYCHIAT, V67, P1422, DOI 10.4088/JCP.v67n0913
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Hildrum B, 2009, DIABETOLOGIA, V52, P583, DOI 10.1007/s00125-009-1271-5
   Igna CV, 2008, PSYCHOSOM MED, V70, P960, DOI 10.1097/PSY.0b013e318189a942
   Kahn R, 2007, CIRCULATION, V115, P1806, DOI 10.1161/CIRCULATIONAHA.106.658336
   Kessler RC, 2003, J AFFECT DISORDERS, V74, P5, DOI 10.1016/S0165-0327(02)00426-3
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Maes M, 1997, ACTA PSYCHIAT SCAND, V95, P212, DOI 10.1111/j.1600-0447.1997.tb09622.x
   McCaffery JM, 2003, PSYCHOSOM MED, V65, P490, DOI 10.1097/01.PSY.0000041545.52924.82
   Pulkki-Råback L, 2009, HEALTH PSYCHOL, V28, P108, DOI 10.1037/a0012646
   Räikkönen K, 2007, DIABETES CARE, V30, P2761
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Räikkönen K, 2007, DIABETES CARE, V30, P872, DOI 10.2337/dc06-1857
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Roriz-Cruz M, 2007, J AM GERIATR SOC, V55, P374, DOI 10.1111/j.1532-5415.2007.01068.x
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Stata Corp, 2008, STAT SOFTW REL 10 1
   Takeuchi T, 2009, DIABETES METAB, V35, P32, DOI 10.1016/j.diabet.2008.06.006
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
   Vanhala M, 2009, ACTA PSYCHIAT SCAND, V119, P137, DOI 10.1111/j.1600-0447.2008.01283.x
   Vogelzangs N, 2007, J GERONTOL A-BIOL, V62, P563, DOI 10.1093/gerona/62.5.563
   Vogelzangs N, 2007, PSYCHONEUROENDOCRINO, V32, P151, DOI 10.1016/j.psyneuen.2006.11.009
   Whitfield JB, 1998, CLIN CHEM, V44, P2480
   Williams RL, 2000, BIOMETRICS, V56, P645, DOI 10.1111/j.0006-341X.2000.00645.x
NR 35
TC 57
Z9 58
U1 1
U2 5
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1832-4274
EI 1839-2628
J9 TWIN RES HUM GENET
JI Twin Res. Hum. Genet.
PD AUG
PY 2010
VL 13
IS 4
BP 347
EP 358
DI 10.1375/twin.13.4.347
PG 12
WC Genetics & Heredity; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Genetics & Heredity; Obstetrics & Gynecology
GA 729ZW
UT WOS:000287994200007
PM 20707705
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Ferriani, LO
   Silva, DA
   Viana, MC
AF Ferriani, Lara Onofre
   Silva, Daniela Alves
   Viana, Maria Carmen
TI ATYPICAL DEPRESSION IS ASSOCIATED WITH METABOLIC SYNDROME: A SYSTEMATIC
   REVIEW
SO ACTAS ESPANOLAS DE PSIQUIATRIA
LA English
DT Review
DE Key words; Metabolic syndrome; atypical depression; depressive subtypes;
   systematic review; mental disorders
ID YOUNG-ADULTS; SYMPTOMS; SUBTYPES; COOCCURRENCE; ANXIETY; HEALTH
AB Introduction. Depression and metabolic syndrome (MetS) are important public health problems. This systematic review evaluated whether the atypical subtype of depression is associated with MetS, when compared to other depressive subtypes. Methods. Two independent reviewers searched in Medline, Lilacs, PsycInfo, Scopus and Web of Science databases, up to May 2021, without language restriction, including cross-sectional, case-control, and cohort studies, assessing adults. The methodological quality of the studies was assessed using the Newcastle-Ottawa Scale. The PRISMA guidelines were adopted and this review was registered in PROSPERO (CRD42018109762). Results. The databases search identified 96 articles and 6 was included in this review. The methodological quality scores ranged from 7 to 10 points. The association between atypical depression and MetS was demonstrated in all publications, as well as the lack of association with melancholic and other subtypes. The prevalence of MetS was significantly higher among individuals with atypical depression. It is worth noting that only few studies assessing this comorbidity were conducted so far. Conclusions. MetS is associated with atypical depression, but not with melancholic or other subtypes. The identification of distinct depressive clinical features seems crucial to better understand its comorbidity with MetS and elucidate its pathophysiological pathways, both necessary to better guide prevention and treatment strategies.
C1 [Ferriani, Lara Onofre] Univ Fed Espirito Santo, Programa Posgrad Salud Publ, Vitoria, Brazil.
   [Silva, Daniela Alves] Univ Fed Espirito Santo, Dept Educ Integrada Salud, Vitoria, Brazil.
   [Viana, Maria Carmen] Univ Fed Espirito Santo, Dept Med Social, Vitoria, Brazil.
   [Viana, Maria Carmen] Univ Fed Espirito Santo, Programa Posgrad Salud Publ, Vitoria, Brazil.
C3 Universidade Federal do Espirito Santo; Universidade Federal do Espirito
   Santo; Universidade Federal do Espirito Santo; Universidade Federal do
   Espirito Santo
RP Ferriani, LO (corresponding author), Univ Fed Espirito Santo, Programa Posgrad Salud Publ, Vitoria, Brazil.; Viana, MC (corresponding author), Univ Fed Espirito Santo, Dept Med Social, Vitoria, Brazil.; Viana, MC (corresponding author), Univ Fed Espirito Santo, Programa Posgrad Salud Publ, Vitoria, Brazil.
EM laraonofref@gmail.com; mcviana6@gmail.com
CR Aggoun Y, 2007, PEDIATR RES, V61, P653, DOI [10.1203/pdr.0b013e31805d8a8c, 10.1210/jc.2004-0372]
   [Anonymous], 1987, Diagnostic and statistical manual of mental disorders: DSM-III-R, V3rd
   Association AP, 2013, Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
   Chan KL, 2019, PHYSIOLOGY, V34, P123, DOI 10.1152/physiol.00047.2018
   Demirci H, 2011, KLIN PSIKOFARMAKOL B, V21, P49
   Gheshlagh RG, 2016, IRAN RED CRESCENT ME, V18, DOI 10.5812/ircmj.26523
   Glaus J, 2013, ACTA PSYCHIAT SCAND, V128, P282, DOI 10.1111/acps.12057
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Herzog R, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-154
   International Diabetes Federation-IDF, 2006, INF IDF CONS WORLDW
   Kessing LV, 2007, ACTA PSYCHIAT SCAND, V115, P85, DOI 10.1111/j.1600-0447.2007.00966.x
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178, DOI 10.4088/JCP.v69n0202
   Lamers F, 2018, PSYCHOL MED, V48, P1102, DOI 10.1017/S0033291717002483
   Lamers F, 2016, BRIT J PSYCHIAT, V208, P62, DOI 10.1192/bjp.bp.114.153098
   Lamers F, 2013, MOL PSYCHIATR, V18, P692, DOI 10.1038/mp.2012.144
   Lamers F, 2010, J CLIN PSYCHIAT, V71, P1582, DOI 10.4088/JCP.09m05398blu
   Lasserre AM, 2017, MOL PSYCHIATR, V22, P1026, DOI 10.1038/mp.2016.178
   Matos Evandro Gomes de, 2006, Estud. psicol. (Campinas), V23, P173
   McIntyre RS, 2009, CURR DIABETES REP, V9, P51, DOI 10.1007/s11892-009-0010-0
   Miettola J, 2008, SCAND J PRIM HEALTH, V26, P203, DOI 10.1080/02813430802117624
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Paredes S, 2016, REV PORT CARDIOL, V35, P5, DOI 10.1016/j.repc.2015.10.006
   Parker G, 2009, REV BRAS PSIQUIATR, V31
   Pulkki-Råback L, 2009, HEALTH PSYCHOL, V28, P108, DOI 10.1037/a0012646
   Scott KM, 2013, INT J CARDIOL, V168, P5293, DOI 10.1016/j.ijcard.2013.08.012
   Silva DA, 2020, OBES REV, V21, DOI 10.1111/obr.12966
   Stunkard AJ, 2003, BIOL PSYCHIAT, V54, P330, DOI 10.1016/S0006-3223(03)00608-5
   Takeuchi T, 2013, PSYCHIAT CLIN NEUROS, V67, P532, DOI 10.1111/pcn.12104
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
   Vanhala M, 2009, ACTA PSYCHIAT SCAND, V119, P137, DOI 10.1111/j.1600-0447.2008.01283.x
   Wells GA., 2001, The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Non-Randomized Studies in Meta-Analysis
   World Health Organization, 2017, WHOMSDMER20172
NR 33
TC 1
Z9 1
U1 0
U2 0
PU JUAN JOSE LOPEZ-IBOR FOUNDATION
PI MADRID
PA NO 2, MADRID, 28035, SPAIN
SN 1139-9287
EI 1578-2735
J9 ACTAS ESP PSIQUIATRI
JI Actas Esp. Psiquiatri.
PD NOV-DEC
PY 2022
VL 50
IS 6
BP 266
EP 275
PG 10
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 8C6HQ
UT WOS:000917707500003
PM 36622714
DA 2025-06-11
ER

PT J
AU Kim, GU
   Kim, N
   Kim, H
AF Kim, Go-Un
   Kim, Namhee
   Kim, Heejung
TI Association between self-reported medical diagnosis of depression and
   metabolic syndrome in a population-based study: A propensity
   score-matched analysis
SO NURSING OPEN
LA English
DT Article
DE depression; metabolic syndrome; nursing; propensity score; triglycerides
ID SLEEP QUALITY; OBESITY; PREVALENCE; MANAGEMENT; GENDER; HEALTH; DIET
AB The aim was to compare the metabolic syndrome in adults with and without depression in Korea using the 2013-2015 Korea National Health and Nutrition Examination Survey. A cross-sectional study was conducted involving secondary data analysis. National survey data on the self-reported medical diagnosis of depression and metabolic syndrome were collected between 2013 and 2015 and released for research purposes in 2017. We conducted a propensity score-matched study that included adults (n = 494) with and without depression at a 1:1 ratio, to reduce the impact of potential confounding factors between groups. Depression was not significantly associated with changes in metabolic syndrome. However, participants with depression had significantly higher triglycerides than those without depression (p = .008), highlighting the importance of periodically checking triglycerides in depressed patients. Nurses need to check the subcomponents of metabolic syndrome in depressed patients periodically, especially regarding the management of triglycerides.
C1 [Kim, Go-Un; Kim, Namhee; Kim, Heejung] Yonsei Univ, Coll Nursing, 50-1 Yonsei Ro, Seoul 03722, South Korea.
   [Kim, Go-Un; Kim, Heejung] Yonsei Univ, Mo Im Kim Nursing Res Inst, 50-1 Yonsei Ro, Seoul 03722, South Korea.
   [Kim, Namhee] Yonsei Univ, Brain Korea 21 FOUR Project, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University
RP Kim, H (corresponding author), Yonsei Univ, Coll Nursing, 50-1 Yonsei Ro, Seoul 03722, South Korea.; Kim, H (corresponding author), Yonsei Univ, Mo Im Kim Nursing Res Inst, 50-1 Yonsei Ro, Seoul 03722, South Korea.
EM hkim80@yuhs.ac
OI Kim, Goun/0000-0001-7191-5134; Kim, Heejung/0000-0003-3719-0111; Kim,
   Namhee/0000-0002-2862-2691
FU Yonsei University College of Nursing; Ministry of Science, ICT and
   Future Planning [NRF-2020R1C1C1012848]; Mo-Im Kim Nursing Research
   Institute [6-2018-0179]
FX This study was supported by the Yonsei University College of Nursing and
   Mo-Im Kim Nursing Research Institute in 2018 (Grant ID: 6-2018-0179) and
   the Ministry of Science, ICT and Future Planning (NRF-2020R1C1C1012848).
   The funder had no role in the design, collection, analysis,
   interpretation, writing or submission decision of this article
CR Cameron AJ, 2004, ENDOCRIN METAB CLIN, V33, P351, DOI 10.1016/j.ecl.2004.03.005
   Fatima Y, 2016, OBES REV, V17, P1154, DOI 10.1111/obr.12444
   Galobardes B, 2006, J EPIDEMIOL COMMUN H, V60, P7, DOI 10.1136/jech.2004.023531
   Gheshlagh RG, 2016, IRAN RED CRESCENT ME, V18, DOI 10.5812/ircmj.26523
   Goldman N, 2003, J CLIN EPIDEMIOL, V56, P148, DOI 10.1016/S0895-4356(02)00580-2
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hahn RA, 2015, INT J HEALTH SERV, V45, P657, DOI 10.1177/0020731415585986
   Hansen BB, 2008, STAT SCI, V23, P219, DOI 10.1214/08-STS254
   Hay SI, 2017, LANCET, V389, pE1
   Iacus SM, 2012, POLIT ANAL, V20, P1, DOI 10.1093/pan/mpr013
   Kim B, 2020, BMC PUBLIC HEALTH, V20, DOI 10.1186/s12889-020-08778-3
   Korea Centers for Disease Control and Prevention, 2015, 6 KOR NAT HLTH NUTR
   Korean Ministry of Health and Welfare, 2013, PHYS ACT GUID KOR
   Korean Society of Sleep Medicine, 2008, APPR SLEEP TIM
   Kruisbrink M, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2017-018585
   Lee SY, 2007, DIABETES RES CLIN PR, V75, P72, DOI 10.1016/j.diabres.2006.04.013
   Lee SWH, 2017, SLEEP MED REV, V31, P91, DOI 10.1016/j.smrv.2016.02.001
   Lee Suk Jeong, 2007, Taehan Kanho Hakhoe Chi, V37, P414
   Lian Y, 2019, PSYCHIAT RES, V274, P66, DOI 10.1016/j.psychres.2019.01.096
   Lo K, 2018, J CLIN HYPERTENS, V20, P592, DOI 10.1111/jch.13220
   Lopresti AL, 2013, J AFFECT DISORDERS, V148, P12, DOI 10.1016/j.jad.2013.01.014
   Lunt M, 2009, AM J EPIDEMIOL, V169, P909, DOI 10.1093/aje/kwn391
   Marazziti D, 2014, CNS SPECTRUMS, V19, P293, DOI 10.1017/S1092852913000667
   Mitchell BD, 2019, J CLIN LIPIDOL, V13, P109, DOI 10.1016/j.jacl.2018.11.006
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   National Heart Lung and Blood Institute, 2013, CALC YOUR BOD MASS I
   Oh J, 2017, J AFFECT DISORDERS, V213, P51, DOI 10.1016/j.jad.2017.02.002
   Pandi-Perumal SR, 2020, PSYCHIAT RES, V291, DOI 10.1016/j.psychres.2020.113239
   Pratt Laura A, 2014, NCHS Data Brief, P1
   Pucci G, 2017, PHARMACOL RES, V120, P34, DOI 10.1016/j.phrs.2017.03.008
   Rethorst CD, 2014, J CLIN PSYCHIAT, V75, pE1428, DOI 10.4088/JCP.14m09009
   Rubin DB, 2006, MATCHED SAMPLING FOR CAUSAL EFFECTS, P365
   Sekita A, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-862
   Shim Moonjung, 2014, [Korean Journal of Clinical Laboratory Science, 대한임상검사과학회지], V46, P67, DOI 10.15324/kjcls.2014.46.2.68
   Skinner AC, 2015, NEW ENGL J MED, V373, P1307, DOI 10.1056/NEJMoa1502821
   Son H, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16060919
   Staffa SJ, 2018, ANESTH ANALG, V127, P1066, DOI 10.1213/ANE.0000000000002787
   Stuart EA, 2010, STAT SCI, V25, P1, DOI 10.1214/09-STS313
   Thabrew H, 2018, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD012489.pub2
   Thom G, 2017, GASTROENTEROLOGY, V152, P1739, DOI 10.1053/j.gastro.2017.01.056
   Tirabassi G, 2014, ENDOCRINE, V46, P370, DOI 10.1007/s12020-013-0112-y
   Blasco BV, 2020, PSYCHIAT INVEST, V17, P715, DOI 10.30773/pi.2020.0099
   Wilsnack RW, 2009, ADDICTION, V104, P1487, DOI 10.1111/j.1360-0443.2009.02696.x
   Wrzosek M, 2018, BMC PSYCHIATRY, V18, DOI 10.1186/s12888-018-1734-7
   Wu H, 2020, J AFFECT DISORDERS, V273, P8, DOI 10.1016/j.jad.2020.03.168
   ,, 2008, The global burden of disease: 2004 update
NR 47
TC 0
Z9 0
U1 1
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2054-1058
J9 NURS OPEN
JI NURS. OPEN
PD JAN
PY 2022
VL 9
IS 1
BP 367
EP 376
DI 10.1002/nop2.1074
EA SEP 2021
PG 10
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA XT2GA
UT WOS:000700820500001
PM 34582126
OA Green Published
DA 2025-06-11
ER

PT J
AU Stanojevic, A
   Popovic, I
   Nenadovic, M
   Ravanic, D
   Paunovic-Milosavljevic, G
AF Stanojevic, Albina
   Popovic, Irena
   Nenadovic, Milutin
   Ravanic, Dragan
   Paunovic-Milosavljevic, Gordana
TI Metabolic Syndrome and C-Reactive Protein in Patients with Depressive
   Disorder on Antidepressive Medication
SO SRPSKI ARHIV ZA CELOKUPNO LEKARSTVO
LA English
DT Article
DE C-reactive protein; Metabolic Syndrome; depression; SSRI pharmacotherapy
ID 3RD NATIONAL-HEALTH; CARDIOVASCULAR-DISEASE; INFLAMMATORY MARKERS; MAJOR
   DEPRESSION; US ADULTS; PREVALENCE; ACTIVATION; MOOD
AB Introduction Recurrent depression is a psychiatric disorder of which etiology and pathogenesis might be related to immune response. Metabolic Syndrome (MetS) and its components are also strongly associated with elevated inflammatory indicators, as so as the body mass index (BMI) and total cholesterol levels.
   Objective Objective of this study was to investigate if there was any difference in C-reactive protein (CRP) levels in patients with recurrent depressive disorder, treated with antidepressants, compared to a healthy control group of subjects and if there was an association between increased CRP levels and the presence of MetS in these two groups.
   Methods Sixty subjects entered the study; of these 35 patients with the diagnosis of recurrent depressive disorder, while the healthy control group included 25 subjects. MetS was defined according to the NCEP ATP III criteria. The cut-off point for CRP was set at >5 mg /L.
   Results There was no statistically significant difference in the prevalence of MetS and CRP values between the studied groups. Waist circumference and total cholesterol levels were significantly higher in the experimental group. Patients that fulfilled the criteria for MetS showed significantly higher values of central obesity and arterial hypertension in the experimental group as well. The elevated CRP levels were associated with increased frequency of MetS in depressed patients.
   Conclusion Both CRP levels and metabolic risk profile screening, according to the international criteria, may be beneficial in order to obtain better assessment for depressive long term medicated patients.
C1 [Stanojevic, Albina; Popovic, Irena] Special Hosp Mental Disorders Gornja Topon, Nish, Serbia.
   [Nenadovic, Milutin] Special Hosp Mental Disorders Laza Lazarev, Belgrade, Serbia.
   [Nenadovic, Milutin] Univ Pristina, Fac Med, Kosovska Mitrovica, Serbia.
   [Ravanic, Dragan] Univ Kragujevac, Dept Psychiat, Kragujevac, Serbia.
C3 Universiteti i Prishtines; University of Kragujevac
RP Popovic, I (corresponding author), Specialized Hosp Psychiat Disorders Gornja Topon, Gornja Toponica 18202, Serbia.
EM ipopovic69@yahoo.com
CR Basu R, 2004, BIPOLAR DISORD, V6, P314, DOI 10.1111/j.1399-5618.2004.00126.x
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cunha AB, 2008, EUR ARCH PSY CLIN N, V258, P300, DOI 10.1007/s00406-007-0797-0
   Devaraj S, 2004, ENDOCRIN METAB CLIN, V33, P431, DOI 10.1016/j.ecl.2004.03.008
   Douglas KM, 2004, PSYCHOSOM MED, V66, P679, DOI 10.1097/01.psy.0000138132.66332.85
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Ford DE, 2004, ARCH INTERN MED, V164, P1010, DOI 10.1001/archinte.164.9.1010
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Ford ES, 2005, DIABETES CARE, V28, P2745, DOI 10.2337/diacare.28.11.2745
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Kirilmaz B, 2010, J CLIN HYPERTENS, V12, P136, DOI 10.1111/j.1751-7176.2009.00229.x
   Lespérance F, 2004, AM J PSYCHIAT, V161, P271, DOI 10.1176/appi.ajp.161.2.271
   Libby P, 2002, CIRCULATION, V105, P1135, DOI 10.1161/hc0902.104353
   Liu HC, 2004, J NEUROIMMUNOL, V150, P116, DOI 10.1016/j.jneuroim.2004.01.006
   Maes M, 1999, ADV EXP MED BIOL, V461, P25
   Miller GE, 2003, BRAIN BEHAV IMMUN, V17, P276, DOI 10.1016/S0889-1591(03)00057-6
   Newcomer JW, 2007, AM J MANAG CARE, V13, pS170
   O'Brien SM, 2006, BRIT J PSYCHIAT, V188, P449, DOI 10.1192/bjp.bp.105.011015
   O'Brien SM, 2006, J AFFECT DISORDERS, V90, P263, DOI 10.1016/j.jad.2005.11.015
   Penninx BWJH, 2001, ARCH GEN PSYCHIAT, V58, P221, DOI 10.1001/archpsyc.58.3.221
   Penninx BWJH, 2003, BIOL PSYCHIAT, V54, P566, DOI 10.1016/S0006-3223(02)01811-5
   Ridker PM, 2000, NEW ENGL J MED, V342, P836, DOI 10.1056/NEJM200003233421202
   Rozanski A, 1999, CIRCULATION, V99, P2192, DOI 10.1161/01.CIR.99.16.2192
   Sluzewska A, 1996, PSYCHIAT RES, V64, P161, DOI 10.1016/S0165-1781(96)02783-7
   Suarez EC, 2004, PSYCHOSOM MED, V66, P684, DOI 10.1097/01.psy.0000138281.73634.67
   World Health Organization, 1992, International statistical classification of diseases and related health problems; Tenth Revision (ICD-10)
   Yumru M, 2007, J AFFECT DISORDERS, V98, P247, DOI 10.1016/j.jad.2006.08.009
NR 28
TC 4
Z9 5
U1 0
U2 5
PU SRPSKO LEKARSKO DRUSTVO
PI BEOGRAD
PA UREDNISTVO CASOPISA SRPSKI ARHIV, UL DZORDZA VASINGTONA 19, BEOGRAD,
   11000, SERBIA
SN 0370-8179
J9 SRP ARK CELOK LEK
JI Srp. Ark. Celok. Lek.
PD JUL-AUG
PY 2013
VL 141
IS 7-8
BP 511
EP 515
DI 10.2298/SARH1308511S
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 230YZ
UT WOS:000325381500013
PM 24073559
OA gold
DA 2025-06-11
ER

PT J
AU Happell, B
   Platania-Phung, C
   Gray, R
   Hardy, S
   Lambert, T
   Mcallister, M
   Davies, C
AF Happell, B.
   Platania-Phung, C.
   Gray, R.
   Hardy, S.
   Lambert, T.
   Mcallister, M.
   Davies, C.
TI A role for mental health nursing in the physical health care of
   consumers with severe mental illness
SO JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING
LA English
DT Article
DE comorbidity; mental health nursing; physical care screening; severe
   mental illness
ID AUSTRALIAN PSYCHIATRIC-PATIENTS; CATIE SCHIZOPHRENIA TRIAL; METABOLIC
   SYNDROME; HEPATITIS-C; MORTALITY; PREVALENCE; OBESITY; STIGMA;
   INDIVIDUALS; DEPRESSION
AB There is extensive international evidence that people with severe mental illness have a lower standard of physical health than the general population. This leads to higher morbidity and mortality rates. Many of the causes for this poor physical health are modifiable. Yet the physical needs of this consumer group are neglected by healthcare systems in Australia, and elsewhere. While medical specialists are clearly integral to remedying this, nurses are well placed to play a key role in focused prevention and early intervention in the physical well-being of consumers with mental health problems. This paper outlines the specifics on how mental health nurses can be sensitized, prepared and empowered to help turn this serious health issue around. In particular, mental health nurses could be trained in and then utilize a new physical health check and response system in the UK (called the Health Improvement Profile) if adapted for use within Australia. This profile will be briefly introduced, and then its value to improving health care discussed.
C1 [Happell, B.; Platania-Phung, C.] CQUniv Australia, Sch Nursing & Midwifery, Inst Hlth & Social Sci Res, Rockhampton, Qld 4702, Australia.
   [Mcallister, M.] Univ Sunshine Coast, Fac Sci Hlth & Educ, Brisbane, Qld, Australia.
   [Lambert, T.] Univ Sydney, Concord Med Sch, Sydney, NSW 2006, Australia.
   [Lambert, T.] Univ Sydney, Brain & Mind Res Inst, Sydney, NSW 2006, Australia.
   [Gray, R.] Univ E Anglia, Fac Hlth, Norwich NR4 7TJ, Norfolk, England.
   [Hardy, S.] Univ E Anglia Nursing, Northamptonshire Teaching PrimaryCare Trust, PhyHWell Project, Norwich, Norfolk, England.
C3 Central Queensland University; University of the Sunshine Coast;
   University of Sydney; University of Sydney; University of East Anglia;
   University of East Anglia
RP Happell, B (corresponding author), CQUniv Australia, Sch Nursing & Midwifery, Inst Hlth & Social Sci Res, Rockhampton, Qld 4702, Australia.
EM b.happell@cqu.edu.au
RI ; Happell, Brenda/HSI-0570-2023; Gray, Richard/C-9945-2017
OI Jennings, Cally/0000-0001-9017-7077; Happell,
   Brenda/0000-0002-7293-6583; Gray, Richard/0000-0001-9694-4206;
   McAllister, Margaret/0000-0003-1181-1610
CR Acil AA, 2008, J PSYCHIATR MENT HLT, V15, P808, DOI 10.1111/j.1365-2850.2008.01317.x
   *ACMHN, 1995, STAND PRACT MENT HLT
   [Anonymous], 2006, CHOOS HLTH SUPP PHYS
   [Anonymous], 1999, Physical activity and health: A report of the surgeon general
   [Anonymous], 2021, Period Products (Free Provision) (Scotland) Act 2021: Guidance for Responsible Bodies'
   Brown S, 2000, BRIT J PSYCHIAT, V177, P212, DOI 10.1192/bjp.177.3.212
   Brown S, 2010, BRIT J PSYCHIAT, V196, P116, DOI 10.1192/bjp.bp.109.067512
   Burbach F., 1997, J MENT HEALTH, V6, P543, DOI DOI 10.1080/09638239718428
   Carney RM, 2003, BIOL PSYCHIAT, V54, P241, DOI 10.1016/S0006-3223(03)00111-2
   Corrigan PW, 2007, AUST PSYCHOL, V42, P90, DOI 10.1080/00050060701280573
   Corrigan PW, 2004, SCHIZOPHRENIA BULL, V30, P481, DOI 10.1093/oxfordjournals.schbul.a007096
   Cournos F, 2005, J CLIN PSYCHIAT, V66, P27
   Daumit GL, 2003, J NERV MENT DIS, V191, P799, DOI 10.1097/01.nmd.0000100923.20188.2d
   Davidson S, 2001, AUST NZ J PSYCHIAT, V35, P203, DOI 10.1046/j.1440-1614.2001.00867.x
   DAVIDSON S, 2000, AUSTRALAS PSYCHIATRY, V8, P31, DOI DOI 10.1046/J.1440-1665.2000.00234.X
   Dickerson FB, 2006, ACTA PSYCHIAT SCAND, V113, P306, DOI 10.1111/j.1600-0447.2005.00637.x
   Drew L, 2007, AUSTRALAS PSYCHIATRY, V15, P320, DOI 10.1080/10398560701320105
   Duckett S.J., 2007, AUSTR HLTH CARE SYST, V3rd
   Dunn AL, 2005, AM J PREV MED, V28, P1, DOI 10.1016/j.amepre.2004.09.003
   Faulkner G, 2002, J Psychiatr Ment Health Nurs, V9, P659, DOI 10.1046/j.1365-2850.2002.00520.x
   Gartshore A, 2009, J PSYCHIATR MENT HLT, V16, P578, DOI 10.1111/j.1365-2850.2009.01408.x
   Gray R, 2009, INT J MENT HEALTH NU, V18, P299, DOI 10.1111/j.1447-0349.2009.00640.x
   HARDY S, 2011, HLTH IMPROVEMENT PRO
   Hardy S., 2008, Practice Nurse, V36, P38
   Hardy S, 2010, INT J MENT HEALTH NU, V19, P350, DOI 10.1111/j.1447-0349.2010.00686.x
   Henderson J, 2008, CONTEMP NURSE, V29, P32, DOI 10.5172/conu.673.29.1.32
   Henderson J, 2008, INT J MENT HEALTH NU, V17, P162, DOI 10.1111/j.1447-0349.2008.00528.x
   Hyland B, 2003, AUST NZ J PSYCHIAT, V37, P710, DOI 10.1111/j.1440-1614.2003.01264.x
   Jackson CL, 2010, MED J AUSTRALIA, V192, P284, DOI 10.5694/j.1326-5377.2010.tb03510.x
   Jensen Linda Welsch, 2006, Issues Ment Health Nurs, V27, P617, DOI 10.1080/01612840600642919
   John AP, 2009, MED J AUSTRALIA, V190, P176, DOI 10.5694/j.1326-5377.2009.tb02342.x
   Lambert TJR, 2009, MED J AUSTRALIA, V190, pS39
   Lambert Timothy J R, 2003, Med J Aust, V178, pS67
   Lambert TJR, 2004, MED J AUSTRALIA, V181, P544, DOI 10.5694/j.1326-5377.2004.tb06443.x
   Lawrence D, 2000, ACTA PSYCHIAT SCAND, V101, P382, DOI 10.1034/j.1600-0447.2000.101005382.x
   Lawrence D, 2001, DUTY CARE PREVENTABL
   Lawrence DM, 2003, BRIT J PSYCHIAT, V182, P31, DOI 10.1192/bjp.182.1.31
   Liggins J, 2005, GEN HOSP PSYCHIAT, V27, P359, DOI 10.1016/j.genhosppsych.2005.05.006
   Lykouras L, 2008, CURR OPIN PSYCHIATR, V21, P398, DOI 10.1097/YCO.0b013e32830079d0
   McEvoy JP, 2005, SCHIZOPHR RES, V80, P19, DOI 10.1016/j.schres.2005.07.014
   Mental Health Council of Australia, 2005, NOT SERV EXP INJ DES
   Mitchell AJ, 2006, CURR OPIN PSYCHIATR, V19, P432
   Muir-Cochrane E, 2001, Aust N Z J Ment Health Nurs, V10, P210, DOI 10.1046/j.1440-0979.2001.00213.x
   Nasrallah HA, 2006, SCHIZOPHR RES, V86, P15, DOI 10.1016/j.schres.2006.06.026
   National Health Workforce Taskforce, 2009, HLTH WORKF AUSTR FAC
   New South Wales Health, 2009, PHYS HLTH CAR MENT H
   Ohlsen R I, 2005, J Psychiatr Ment Health Nurs, V12, P614
   Osborn DPJ, 2001, WESTERN J MED, V175, P329, DOI 10.1136/ewjm.175.5.329
   Penedo FJ, 2005, CURR OPIN PSYCHIATR, V18, P189, DOI 10.1097/00001504-200503000-00013
   Phelan M, 2001, BRIT MED J, V322, P443, DOI 10.1136/bmj.322.7284.443
   *QUEENSL GOV, 2005, SHAR RESP REC CREAT
   Richardson CR, 2005, PSYCHIAT SERV, V56, P324, DOI 10.1176/appi.ps.56.3.324
   Robson D, 2007, INT J NURS STUD, V44, P457, DOI 10.1016/j.ijnurstu.2006.07.013
   Saxena S., 2005, J MENTAL HLTH, V14, P445, DOI DOI 10.1080/09638230500270776
   Schwartz T L, 2004, Obes Rev, V5, P233, DOI 10.1111/j.1467-789X.2004.00149.x
   Shanley E, 2003, J Psychiatr Ment Health Nurs, V10, P431, DOI 10.1046/j.1365-2850.2003.00631.x
   Shattell MM, 2007, INT J MENT HEALTH NU, V16, P274, DOI 10.1111/j.1447-0349.2007.00477.x
   Shuel F, 2010, INT J NURS STUD, V47, P136, DOI 10.1016/j.ijnurstu.2009.06.003
   Sokal J, 2004, J NERV MENT DIS, V192, P421, DOI 10.1097/01.nmd.0000130135.78017.96
   Tardieu S, 2003, Obes Rev, V4, P129, DOI 10.1046/j.1467-789X.2003.00105.x
   Tosh G, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008298.pub2
   Wallace B, 1998, AUST NZ J PSYCHIAT, V32, P82, DOI 10.3109/00048679809062711
   Wand T, 2008, INT J MENT HEALTH NU, V17, P363, DOI 10.1111/j.1447-0349.2008.00559.x
   Weiner E, 2001, AM J PSYCHIAT, V158, P635, DOI 10.1176/appi.ajp.158.4.635
   White J, 2009, J PSYCHIATR MENT HLT, V16, P493, DOI 10.1111/j.1365-2850.2009.01375.x
NR 65
TC 47
Z9 51
U1 0
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1351-0126
EI 1365-2850
J9 J PSYCHIATR MENT HLT
JI J. Psychiatr. Ment. Health Nurs.
PD OCT
PY 2011
VL 18
IS 8
BP 706
EP 711
DI 10.1111/j.1365-2850.2010.01666.x
PG 6
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 820KU
UT WOS:000294905400008
PM 21896113
DA 2025-06-11
ER

PT J
AU Jo, KJ
   Nam, GH
   Park, YS
   Kawk, HW
   Kim, JT
   Choi, WH
   Jang, SH
   Kim, MJ
   Kim, YM
AF Jo, Kyung Jo
   Nam, Gun He
   Park, Ye Seul
   Kawk, Hye Won
   Kim, Jong Tae
   Choi, Won Hee
   Jang, Seung Hee
   Kim, Min Jeong
   Kim, Young Min
TI Evaluation of Stress-related Behavioral and Biological Activity of
   Ocimum sanctum Extract in Rats
SO BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
LA English
DT Article
DE Ocimum sanctum; restraint stress; sleep deprivation; anti-anxiety;
   hypothalamic pituitary adrenal axis (HPA axis); cortisol; AMPK; Glut4;
   Acetyl-CoA carboxylase (ACC); glucose metabolism; insulin resistance
ID ACTIVATED PROTEIN-KINASE; SHORT-SLEEP DURATION; MELATONIN SYNTHESIS;
   ELEVATED GHRELIN; REDUCED LEPTIN; PINEAL-GLAND; RISK-FACTOR; INSOMNIA;
   ANXIETY; ANTIDEPRESSANTS
AB Stress is an emerging and inevitable entity. Stress causes anxiety, depression, imbalance of homeostasis, hormone imbalance, and sleep disturbances that are closely related to the onset of metabolic syndrome. The objective of this study was to investigate effects of Ocimum sanctum extract (TZ-OSE) on anti-anxiety, anti-stress, and control of physiological changes due to sleep disturbance in a rat model with restraint stress and sleep disorder induced. After inducing the rat model with restraint stress, three behavioral tests were performed and blood cortisol concentration was determined. In Elevated plus maze test, the test substance TZ-OSE at dose of 200 mg/kg showed the best effect in increasing time that stayed on the open arms. In tail suspension test (TST) and forced swimming test (FST), TZ-OSE significantly reduced immobility duration time (IMT). TZ-OSE also decreased plasma cortisol concentration. In the model after inducing sleep disturbance, ELISA, Western blotting, and Immuno-histochemistry (IHC) were conducted. TZ-OSE treatment decreased plasma cortisol, norepinephrine, glucose, and acylated ghrelin concentrations in the rat model with sleep disorders induced. Decreases of melatonin and leptin levels in the plasma of the rat model with sleep disorders induced were increased by TZ-OSE treatment. Finally, TZ-OSE treatment decreased metabolism-related markers (p-AMPK, Glut-4, p-ACC) in stomach and muscle tissues and decreased the expression of cortisol in adrenal gland tissues. Taken together, these results suggest that TZ-OSE can decrease anxiety, depression, and stress in vivo, regulate sleep-related factors, and control energy metabolism index factors.
C1 [Jo, Kyung Jo; Nam, Gun He; Park, Ye Seul; Kawk, Hye Won; Kim, Young Min] Hannam Univ, Dept Biol Sci & Biotechnol, Daejeon 34054, South Korea.
   [Kim, Jong Tae; Choi, Won Hee; Jang, Seung Hee; Kim, Min Jeong] Teazen Co Ltd, Haenam 59017, South Korea.
C3 Hannam University
RP Kim, YM (corresponding author), Hannam Univ, Dept Biol Sci & Biotechnol, Daejeon 34054, South Korea.
EM kym@hnu.ac.kr
RI Kim, Young-Min/JLL-7158-2023
OI Nam, Gun He/0000-0002-7737-8947
FU Technology development Program - Ministry of SMEs and Startups (MSS,
   Korea) [S2449517]
FX This work was supported by the Technology development Program(S2449517)
   funded by the Ministry of SMEs and Startups (MSS, Korea).
CR Anothaisintawee T, 2016, SLEEP MED REV, V30, P11, DOI 10.1016/j.smrv.2015.10.002
   Bathala Lakshmana Rao, 2012, J Contemp Dent Pract, V13, P782
   Bjorvatn B, 2007, J SLEEP RES, V16, P66, DOI 10.1111/j.1365-2869.2007.00569.x
   Bonnet MH, 2000, SLEEP, V23, P205
   Bremness L, 1988, COMPLETE BOOK HERBS, P238
   Chaput JP, 2007, OBESITY, V15, P253, DOI 10.1038/oby.2007.512
   Chen WW, 2011, PHYTOMEDICINE, V18, P1144, DOI 10.1016/j.phymed.2011.06.004
   Choi Y J, 2000, HERB LIFE, P177
   CLARK AJ, 1995, J ADV NURS, V22, P562, DOI 10.1046/j.1365-2648.1995.22030562.x
   de Kloet ER, 2005, NAT REV NEUROSCI, V6, P463, DOI 10.1038/nrn1683
   Fisslthaler B, 2009, CIRC RES, V105, P114, DOI 10.1161/CIRCRESAHA.109.201590
   Foretz M, 1998, J BIOL CHEM, V273, P14767, DOI 10.1074/jbc.273.24.14767
   Ganguly S, 2002, CELL TISSUE RES, V309, P127, DOI 10.1007/s00441-002-0579-y
   Gangwisch JE, 2005, SLEEP, V28, P1289, DOI 10.1093/sleep/28.10.1289
   Glass J, 2005, BMJ-BRIT MED J, V331, P1169, DOI 10.1136/bmj.38623.768588.47
   Gottlieb DJ, 2005, ARCH INTERN MED, V165, P863, DOI 10.1001/archinte.165.8.863
   Gunja N, 2013, J MED TOXICOL, V9, P155, DOI 10.1007/s13181-013-0292-0
   Gupta P, 2007, J NAT PROD, V70, P1410, DOI 10.1021/np0700164
   Hardie DG, 2007, NAT REV MOL CELL BIO, V8, P774, DOI 10.1038/nrm2249
   He YH, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0070135
   Kindler S, 1997, CLIN NEUROPHARMACOL, V20, P466, DOI 10.1097/00002826-199710000-00012
   Koistinen HA, 2003, DIABETES, V52, P1066, DOI 10.2337/diabetes.52.5.1066
   Korf H.-W., 1998, Advances in Anatomy Embryology and Cell Biology, V146, P1
   Kumar RS, 2007, PHARMACOLOGYONLINE, V3, P394
   Leach MJ, 2015, SLEEP MED REV, V24, P1, DOI 10.1016/j.smrv.2014.12.003
   Leproult R, 1997, SLEEP, V20, P865
   LISTER RG, 1987, PSYCHOPHARMACOLOGY, V92, P180
   Mediratta PK, 2002, J ETHNOPHARMACOL, V80, P15, DOI 10.1016/S0378-8741(01)00373-7
   Mitsuhashi K, 2016, ENDOCRINE, V51, P174, DOI 10.1007/s12020-015-0666-y
   Morselli LL, 2012, PFLUG ARCH EUR J PHY, V463, P139, DOI 10.1007/s00424-011-1053-z
   Narendhirakannan RT, 2006, CLIN EXP PHARMACOL P, V33, P1150, DOI 10.1111/j.1440-1681.2006.04507.x
   Park S O, 2002, KOREAN J RURAL MED, V27, P17
   Park SY, 2013, MOL CELL ENDOCRINOL, V371, P114, DOI 10.1016/j.mce.2012.11.010
   PORSOLT RD, 1977, NATURE, V266, P730, DOI 10.1038/266730a0
   Prasad M. P. V., 2012, Research Journal of Medicinal Plant, V6, P37, DOI 10.3923/rjmp.2012.37.46
   Prinz PN, 2000, CHRONOBIOL INT, V17, P391, DOI 10.1081/CBI-100101053
   Saxena RC, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/894509
   Selye H., 1982, HDB STRESS, P7
   SEN P, 1992, Indian Journal of Experimental Biology, V30, P592
   Singh S, 2001, J ETHNOPHARMACOL, V78, P139, DOI 10.1016/S0378-8741(01)00336-1
   Spiegel K, 1999, LANCET, V354, P1435, DOI 10.1016/S0140-6736(99)01376-8
   Spiegel K, 2004, ANN INTERN MED, V141, P846, DOI 10.7326/0003-4819-141-11-200412070-00008
   STERU L, 1985, PSYCHOPHARMACOLOGY, V85, P367, DOI 10.1007/BF00428203
   Tabassum I, 2010, INDIAN J PHARMACOL, V42, P283, DOI 10.4103/0253-7613.70108
   Taheri S, 2004, PLOS MED, V1, P210, DOI 10.1371/journal.pmed.0010062
   Vaswani M, 2003, PROG NEURO-PSYCHOPH, V27, P85, DOI 10.1016/S0278-5846(02)00338-X
   Vats V, 2002, J ETHNOPHARMACOL, V79, P95, DOI 10.1016/S0378-8741(01)00374-9
   Vgontzas AN, 2001, J CLIN ENDOCR METAB, V86, P3787, DOI 10.1210/jc.86.8.3787
   Voorhees JL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0058488
   Wesensten NJ, 1999, J SLEEP RES, V8, P237, DOI 10.1046/j.1365-2869.1999.00161.x
   Woods A, 2000, MOL CELL BIOL, V20, P6704, DOI 10.1128/MCB.20.18.6704-6711.2000
   WURTMAN RJ, 1963, SCIENCE, V142, P1071, DOI 10.1126/science.142.3595.1071
   Yaggi HK, 2006, DIABETES CARE, V29, P657, DOI 10.2337/diacare.29.03.06.dc05-0879
   Yanpallewar SU, 2004, PHARMACOL BIOCHEM BE, V79, P155, DOI 10.1016/j.pbb.2004.07.008
   우남식, 2013, [Korean Journal of Fisheries and Aquatic Sciences, 한국수산과학회지], V46, P702
   Zhdanova IV, 2001, J CLIN ENDOCR METAB, V86, P4727, DOI 10.1210/jc.86.10.4727
   Zohar J, 2000, ACTA PSYCHIAT SCAND, V101, P39, DOI 10.1111/j.1600-0447.2000.tb10947.x
NR 57
TC 3
Z9 3
U1 1
U2 7
PU KOREAN SOC BIOTECHNOLOGY & BIOENGINEERING
PI SEOUL
PA KOREAN SCIENCE TECHNOLOGY CENTER, #704 YEOGSAM-DONG, KANGNAM-KU, SEOUL
   135-703, SOUTH KOREA
SN 1226-8372
EI 1976-3816
J9 BIOTECHNOL BIOPROC E
JI Biotechnol. Bioprocess Eng.
PD MAR
PY 2020
VL 25
IS 2
BP 170
EP 180
DI 10.1007/s12257-019-0365-2
EA APR 2020
PG 11
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA LI5QG
UT WOS:000526236500002
DA 2025-06-11
ER

PT J
AU Dickerson, SS
   Gruenewald, TL
   Kemeny, ME
AF Dickerson, SS
   Gruenewald, TL
   Kemeny, ME
TI When the social self is threatened: Shame, physiology, and health
SO JOURNAL OF PERSONALITY
LA English
DT Article
ID C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA; GLUCOCORTICOID RESISTANCE;
   PSYCHOLOGICAL STRESS; CYTOKINE PRODUCTION; METABOLIC SYNDROME; HIV
   PROGRESSION; DEPRESSION; GUILT; EMBARRASSMENT
AB Our program of research focuses on shame as a key emotional response to "social self" threats (i.e., social evaluation or rejection). We propose that shame may orchestrate specific patterns of psychobiological changes under these conditions. A series of studies demonstrates that acute threats to the social self increase proinflammatory cytokine activity and cortisol and that these changes occur in concert with shame. Chronic social self threats and persistent experience of shame-related cognitive and affective states predict disease-relevant immunological and health outcomes in HIV. Across our laboratory and longitudinal studies, general or composite affective states (e.g., distress) are unrelated to these physiological and health outcomes. These findings support a stressor- and emotional response-specificity model for psychobiological and health research.
C1 Univ Calif Los Angeles, Los Angeles, CA USA.
   Univ Calif San Francisco, San Francisco, CA 94143 USA.
C3 University of California System; University of California Los Angeles;
   University of California System; University of California San Francisco
RP Univ Calif Irvine, Dept Psychol & Social Behav, 3340 Social Ecol 2, Irvine, CA 92697 USA.
EM sdickers@uci.edu
RI Gruenewald, Tara/KLE-3300-2024
FU NIMH NIH HHS [MH42918] Funding Source: Medline
CR Ackerman KD, 1998, PSYCHOSOM MED, V60, P484, DOI 10.1097/00006842-199807000-00016
   Altemus M, 2001, J INVEST DERMATOL, V117, P309, DOI 10.1046/j.1523-1747.2001.01373.x
   Andrews B, 2002, BRIT J CLIN PSYCHOL, V41, P29, DOI 10.1348/014466502163778
   [Anonymous], HDB COGNITION EMOTIO
   [Anonymous], Truth
   Atkinson J., 1958, MOTIVES FANTASY ACTI
   ATKINSON JW, 1957, PSYCHOL REV, V64, P359, DOI 10.1037/h0043445
   AUSUBEL DP, 1955, PSYCHOL REV, V62, P378, DOI 10.1037/h0042534
   Avitsur R, 2001, HORM BEHAV, V39, P247, DOI 10.1006/hbeh.2001.1653
   Benedict R., 1946, The Chrysanthemum and the Sword: Patterns of Japanese Culture
   Black PH, 2002, J PSYCHOSOM RES, V52, P1, DOI 10.1016/S0022-3999(01)00302-6
   Blascovich J., 2000, Feeling and thinking: The role of affect in social cognition, P59
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   Buss A.H., 1980, SELF CONSCIOUSNESS S
   Canli T, 2001, BEHAV NEUROSCI, V115, P33, DOI 10.1037//0735-7044.115.1.33
   Cole S., 2001, Psychoneuroimmunology, V2, P583
   Cole SW, 1997, J PERS SOC PSYCHOL, V72, P320, DOI 10.1037/0022-3514.72.2.320
   COLE SW, IN PRESS BIOL PSYCHI
   Connor TJ, 1998, LIFE SCI, V62, P583, DOI 10.1016/S0024-3205(97)00990-9
   Cooley C.H., 1902, Human nature and the social order
   Damasio AR, 2000, NAT NEUROSCI, V3, P1049, DOI 10.1038/79871
   Danesh J, 2000, BMJ-BRIT MED J, V321, P199, DOI 10.1136/bmj.321.7255.199
   Danesh J, 1998, JAMA-J AM MED ASSOC, V279, P1477, DOI 10.1001/jama.279.18.1477
   DANTZER R, 2001, PSYCHONEUROIMMUNOLOG, P583
   Darwin C., 1899, DESCENT MAN, V2nd
   Dickerson SS, 2004, PSYCHOSOM MED, V66, P124, DOI 10.1097/01.PSY.0000097338.75454.29
   Dickerson SS, 2004, PSYCHOL BULL, V130, P355, DOI 10.1037/0033-2909.130.3.355
   DICKERSON SS, 2004, ANN M SOC PERS SOC P
   DUGUE B, 1993, SCAND J CLIN LAB INV, V53, P555, DOI 10.3109/00365519309092553
   EKMAN P, 1983, SCIENCE, V221, P1208, DOI 10.1126/science.6612338
   Elliot AJ, 2004, PERS SOC PSYCHOL B, V30, P957, DOI 10.1177/0146167203262024
   FAHEY JL, 1990, NEW ENGL J MED, V322, P166, DOI 10.1056/NEJM199001183220305
   Feldmann M, 1996, ANNU REV IMMUNOL, V14, P397, DOI 10.1146/annurev.immunol.14.1.397
   Ford ES, 2003, ATHEROSCLEROSIS, V168, P351, DOI 10.1016/S0021-9150(03)00134-5
   Gehm T.L., 1988, FACETS EMOTION, P61
   Gilbert P, 1997, BRIT J MED PSYCHOL, V70, P113, DOI 10.1111/j.2044-8341.1997.tb01893.x
   Gilbert P., 2000, Subordination and defeat: An evolutionary approach to mood disorders and their therapy
   Gilbert P., 1990, Shyness and embarrassment: Perspectives from social psychology, P144
   Goebel MU, 2000, PSYCHOSOM MED, V62, P591, DOI 10.1097/00006842-200007000-00019
   Gold PW, 1995, ANN NY ACAD SCI, V771, P716, DOI 10.1111/j.1749-6632.1995.tb44723.x
   GRUENEWALD TL, IN PRESS PSYCHOSOMAT
   Haller J, 1996, BEHAV NEUROSCI, V110, P353, DOI 10.1037/0735-7044.110.2.353
   Harris TB, 1999, AM J MED, V106, P506, DOI 10.1016/S0002-9343(99)00066-2
   HART BL, 1988, NEUROSCI BIOBEHAV R, V12, P123, DOI 10.1016/S0149-7634(88)80004-6
   Kedzierska K, 2003, REV MED VIROL, V13, P39, DOI 10.1002/rmv.369
   Keltner D, 1996, COGNITION EMOTION, V10, P155, DOI 10.1080/026999396380312
   KELTNER D, 1995, J PERS SOC PSYCHOL, V68, P441, DOI 10.1037/0022-3514.68.3.441
   Keltner D, 1997, AGGRESSIVE BEHAV, V23, P359, DOI 10.1002/(SICI)1098-2337(1997)23:5<359::AID-AB5>3.0.CO;2-D
   Keltner D, 1999, COGNITION EMOTION, V13, P467, DOI 10.1080/026999399379140
   KEMENY ME, 1995, AIDS EDUC PREV, V7, P36
   Kemeny ME, 2003, CURR DIR PSYCHOL SCI, V12, P124, DOI 10.1111/1467-8721.01246
   KEMENY ME, 2004, UNPUB SOCIAL SELF PR
   Kenis G, 2002, INT J NEUROPSYCHOPH, V5, P401, DOI 10.1017/S1461145702003164
   Kronfol Z, 2000, AM J PSYCHIAT, V157, P683, DOI 10.1176/appi.ajp.157.5.683
   Lane RD, 1997, AM J PSYCHIAT, V154, P926
   Leary MR, 2000, ADV EXP SOC PSYCHOL, V32, P1, DOI 10.1016/S0065-2601(00)80003-9
   LEIWS TT, 2004, UNPUB PERCEIVED INTE
   Levenson R.W., 1994, NATURE EMOTION FUNDA, P252
   Lewis M, 2002, CHILD DEV, V73, P1034, DOI 10.1111/1467-8624.00455
   Lovallo R., 2000, HDB PSYCHOPHYSIOLOGY, V2nd, P342, DOI DOI 10.1017/9781107415782
   MAES M, 1995, J AFFECT DISORDERS, V34, P291, DOI 10.1016/0165-0327(95)00027-K
   Maes M, 1999, ADV EXP MED BIOL, V461, P25
   Maier SF, 1998, PSYCHOL REV, V105, P83, DOI 10.1037/0033-295X.105.1.83
   MASON JW, 1968, PSYCHOSOM MED, V30, P576, DOI 10.1097/00006842-196809000-00020
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   Miller GE, 2002, AM J CARDIOL, V90, P1279, DOI 10.1016/S0002-9149(02)02863-1
   MOKROS HB, 1995, AM BEHAV SCI, V38, P1091, DOI 10.1177/0002764295038008005
   MUNCK A, 1984, ENDOCR REV, V5, P25, DOI 10.1210/edrv-5-1-25
   Pasic J, 2003, PSYCHOSOM MED, V65, P181, DOI 10.1097/01.PSY.0000058372.50240.38
   Peters ML, 1999, PSYCHOSOM MED, V61, P513, DOI 10.1097/00006842-199907000-00016
   PRICE J, 1994, BRIT J PSYCHIAT, V164, P309, DOI 10.1192/bjp.164.3.309
   Quan N, 2001, J NEUROIMMUNOL, V115, P36, DOI 10.1016/S0165-5728(01)00273-9
   Rohleder N, 2001, PSYCHOSOM MED, V63, P966, DOI 10.1097/00006842-200111000-00016
   Russell JA, 2003, PSYCHOL REV, V110, P145, DOI 10.1037/0033-295X.110.1.145
   SAPOLSKY RM, 1993, RECENT PROG HORM RES, V48, P437
   Sapolsky RM, 2000, ENDOCR REV, V21, P55, DOI 10.1210/er.21.1.55
   Scheibelhofer K, 2001, INT FED INFO PROC, V64, P3
   Schwarzer R., 1986, Self-related cognitions in anxiety and motivation: An introduction, P1
   Segerstrom SC, 1996, HEALTH PSYCHOL, V15, P485, DOI 10.1037/0278-6133.15.6.485
   Seyle H., 1956, STRESS LIFE
   Shively CA, 1997, BIOL PSYCHIAT, V41, P871, DOI 10.1016/S0006-3223(96)00185-0
   SHOTT S, 1979, AM J SOCIOL, V84, P1317, DOI 10.1086/226936
   Smith RH, 2002, J PERS SOC PSYCHOL, V83, P138, DOI 10.1037//0022-3514.83.1.138
   Stark JL, 2002, J NEUROIMMUNOL, V124, P9, DOI 10.1016/S0165-5728(02)00004-8
   Stark JL, 2001, AM J PHYSIOL-REG I, V280, pR1799, DOI 10.1152/ajpregu.2001.280.6.R1799
   Stefanski V, 1998, PHYSIOL BEHAV, V64, P733, DOI 10.1016/S0031-9384(98)00127-9
   Tangney JP, 1996, J PERS SOC PSYCHOL, V70, P1256, DOI 10.1037/0022-3514.70.6.1256
   TANGNEY JP, 1995, AM BEHAV SCI, V38, P1132, DOI 10.1177/0002764295038008008
   TANGNEY JP, 1992, J ABNORM PSYCHOL, V101, P469, DOI 10.1037/0021-843X.101.3.469
   TOOBY J, 1990, ETHOL SOCIOBIOL, V11, P375, DOI 10.1016/0162-3095(90)90017-Z
   WATKINS LR, 1999, CYTOKINES STRESS DEP
   WEINER B, 1985, PSYCHOL REV, V92, P548, DOI 10.1037/0033-295X.92.4.548
   Weiner H., 1992, PERTURBING ORGANISM
   Weitzman O., 2004, HIV related shame and guilt predict CD4 decline
   WICKER FW, 1983, MOTIV EMOTION, V7, P25, DOI 10.1007/BF00992963
   Yirmiya R, 1999, ADV EXP MED BIOL, V461, P283
   ZAKOWSKI SG, 1992, HEALTH PSYCHOL, V11, P223, DOI 10.1037/0278-6133.11.4.223
NR 97
TC 512
Z9 689
U1 5
U2 122
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3506
EI 1467-6494
J9 J PERS
JI J. Pers.
PD DEC
PY 2004
VL 72
IS 6
BP 1191
EP 1216
DI 10.1111/j.1467-6494.2004.00295.x
PG 26
WC Psychology, Social
WE Social Science Citation Index (SSCI)
SC Psychology
GA 866EJ
UT WOS:000224756300005
PM 15509281
DA 2025-06-11
ER

PT J
AU Kunugi, H
AF Kunugi, Hiroshi
TI Depression and lifestyle: Focusing on nutrition, exercise, and their
   possible relevance to molecular mechanisms
SO PSYCHIATRY AND CLINICAL NEUROSCIENCES
LA English
DT Review
DE depression; diet; exercise; lifestyle; sleep
ID AMINO-ACID PROFILE; BODY-MASS INDEX; VITAMIN-D; METABOLIC SYNDROME;
   COGNITIVE FUNCTION; MENTAL-HEALTH; EICOSAPENTAENOIC ACID; NEUROTROPHIC
   FACTOR; TREATMENT OUTCOMES; MAJOR DEPRESSION
AB Accumulating evidence has suggested the important role of lifestyle factors in depressive disorder. This paper aimed to introduce and outline recent research on epidemiological and intervention studies on lifestyle-related factors in depressive disorder with a special focus on diet. Evidence on exercise, sleep. and related behaviors is also described. Here, findings from meta-analytic studies are emphasized and related studies by the author's research group are introduced. Dietary factors that increase the risk of the illness include energy overload, skipping breakfast, unhealthy diet styles such as Western diet, inflammation-prone diet, and high consumption of ultraprocessed food (UPF). Nutritional imbalances such as inadequate intake of protein, fish (omega 3 polyunsaturated fatty acids), vitamins (folate and vitamin D), and minerals (iron and zinc) increases the risk of depression. Poor oral hygiene, food allergy, addiction to alcohol, and smoking constitute risk factors. Sedentary lifestyle and increased screen time (e.g. video games and the internet) confer the risk of depression. Insomnia and disturbed sleep-wake rhythm are also involved in the pathogenesis of depression. There is accumulating evidence at the meta-analysis level for interventions to modify these lifestyle habits in the protection and treatment of depressive disorder. Main biological mechanisms of the link between lifestyle factors and depression include monoamine imbalance, inflammation, altered stress response, oxidative stress, and dysfunction of brain-derived neurotrophic factor, although other players such as insulin, leptin, and orexin also play a role. To increase resilience to modern stress and ameliorate depression through modification of lifestyle habits, a list of 30 recommendable interventions is presented.
C1 [Kunugi, Hiroshi] Teikyo Univ, Dept Psychiat, Sch Med, Tokyo, Japan.
C3 Teikyo University
RP Kunugi, H (corresponding author), Teikyo Univ, Dept Psychiat, Sch Med, Tokyo, Japan.
EM hkunugi@med.teikyo-u.ac.jp
CR Aizawa E., 2019, J NUTR, P29
   Aizawa E, 2019, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00730
   Aizawa E, 2016, J AFFECT DISORDERS, V202, P254, DOI 10.1016/j.jad.2016.05.038
   Al Maruf A, 2022, PHARMACOPSYCHIATRY, V55, P139, DOI 10.1055/a-1681-2047
   Albacar G, 2011, J AFFECT DISORDERS, V131, P136, DOI 10.1016/j.jad.2010.11.006
   Ali AM, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17249379
   Ali S, 2006, DIABETIC MED, V23, P1165, DOI 10.1111/j.1464-5491.2006.01943.x
   Alyahya RA, 2022, CUREUS J MED SCIENCE, V14, DOI 10.7759/cureus.25651
   American Psychiatric Association (APA), 2013, Diagnostic and Statistical Manual of Mental Disorders, V5th ed
   Anglin RES, 2013, BRIT J PSYCHIAT, V202, P100, DOI 10.1192/bjp.bp.111.106666
   Babyak M, 2000, PSYCHOSOM MED, V62, P633, DOI 10.1097/00006842-200009000-00006
   Bedson E, 2014, HEALTH TECHNOL ASSES, V18, P1, DOI 10.3310/hta18480
   Bender A, 2017, J PSYCHIATR RES, V95, P9, DOI 10.1016/j.jpsychires.2017.07.019
   Beran M, 2022, DIABETIC MED, V39, DOI 10.1111/dme.14671
   Berthelot E, 2021, NUTRIENTS, V13, DOI 10.3390/nu13113947
   Bhalla P, 2007, INDIAN J EXP BIOL, V45, P954
   Bhutani S, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020671
   Bloch MH, 2012, MOL PSYCHIATR, V17, P1272, DOI 10.1038/mp.2011.100
   Blumenthal JA, 2007, PSYCHOSOM MED, V69, P587, DOI 10.1097/PSY.0b013e318148c19a
   Blumenthal JA, 2012, JAMA-J AM MED ASSOC, V308, P465, DOI 10.1001/jama.2012.8720
   Boden JM, 2010, BRIT J PSYCHIAT, V196, P440, DOI 10.1192/bjp.bp.109.065912
   Bottiglieri T, 2005, PROG NEURO-PSYCHOPH, V29, P1103, DOI 10.1016/j.pnpbp.2005.06.021
   Bowler Diana E, 2010, BMC Public Health, V10, P456, DOI 10.1186/1471-2458-10-456
   Braçe O, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17197014
   Briggs R, 2023, J MENT HEALTH, V32, P787, DOI 10.1080/09638237.2022.2118687
   Cademartori MG, 2018, CLIN ORAL INVEST, V22, P2685, DOI 10.1007/s00784-018-2611-y
   Capuron L, 2011, PHARMACOL THERAPEUT, V130, P226, DOI 10.1016/j.pharmthera.2011.01.014
   Ceccherini C, 2022, NUTRIENTS, V14, DOI 10.3390/nu14132689
   Chaiton MO, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-356
   Chen NS, 1997, MOL PHARMACOL, V51, P1015, DOI 10.1124/mol.51.6.1015
   Chenini S, 2022, MOVEMENT DISORD, V37, P812, DOI 10.1002/mds.28903
   Coppen A, 2000, J AFFECT DISORDERS, V60, P121, DOI 10.1016/S0165-0327(00)00153-1
   Dai W, 2022, J ETHNOPHARMACOL, V285, DOI 10.1016/j.jep.2021.114692
   Dallaspezia S, 2011, EXPERT REV NEUROTHER, V11, P961, DOI [10.1586/ERN.11.61, 10.1586/ern.11.61]
   Dewey KG, 2017, AM J CLIN NUTR, V106, p1694S, DOI 10.3945/ajcn.117.156075
   Dreher ML, 2018, NUTRIENTS, V10, DOI 10.3390/nu10121833
   Duc HN, 2021, J NUTR SCI, V10, DOI 10.1017/jns.2021.23
   Duman RS, 2006, BIOL PSYCHIAT, V59, P1116, DOI 10.1016/j.biopsych.2006.02.013
   Erickson KI, 2011, P NATL ACAD SCI USA, V108, P3017, DOI 10.1073/pnas.1015950108
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   Fatahi S, 2021, COMPLEMENT THER MED, V56, DOI 10.1016/j.ctim.2020.102621
   FERNANDEZRODRIG.R, 2022, J SPORT HEALTH SCI, DOI DOI 10.1080/10408398.2022.2088687
   Ferrari AJ, 2013, PLOS MED, V10, DOI 10.1371/journal.pmed.1001547
   Firth J, 2018, NEUROIMAGE, V166, P230, DOI 10.1016/j.neuroimage.2017.11.007
   Freeman MP, 2006, J CLIN PSYCHIAT, V67, P1954, DOI 10.4088/JCP.v67n1217
   Fu RR, 2022, OBES RES CLIN PRACT, V16, P10, DOI 10.1016/j.orcp.2021.11.002
   Fulton S, 2022, TRENDS ENDOCRIN MET, V33, P18, DOI 10.1016/j.tem.2021.10.005
   Galima SV, 2020, AM FAM PHYSICIAN, V102, P668
   Gascon M, 2018, ENVIRON RES, V162, P231, DOI 10.1016/j.envres.2018.01.012
   Gentile DA, 2011, PEDIATRICS, V127, pE319, DOI 10.1542/peds.2010-1353
   Gill H, 2019, J AFFECT DISORDERS, V246, P886, DOI 10.1016/j.jad.2018.12.113
   Gloth F M 3rd, 1999, J Nutr Health Aging, V3, P5
   Gomi C, 2022, NEUROPSYCHOPHARM REP, V42, P84, DOI 10.1002/npr2.12231
   Goralczyk-Binkowska A, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms231911245
   Gordon BR, 2018, JAMA PSYCHIAT, V75, P566, DOI 10.1001/jamapsychiatry.2018.0572
   Gossard TR, 2021, NEUROTHERAPEUTICS, V18, P140, DOI 10.1007/s13311-021-01019-4
   Graham EA, 2020, J AFFECT DISORDERS, V265, P224, DOI 10.1016/j.jad.2020.01.053
   Grosso G, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0096905
   Guo M, 2014, CLIN EXP PHARMACOL P, V41, P650, DOI 10.1111/1440-1681.12265
   Guu TW, 2019, PSYCHOTHER PSYCHOSOM, V88, P263, DOI [10.1159/000502652, 10.1159/000504232]
   Harvey SB, 2018, AM J PSYCHIAT, V175, P28, DOI 10.1176/appi.ajp.2017.16111223
   Hattori K, 2015, SCI REP-UK, V5, DOI 10.1038/srep11412
   Hattori S, 2007, BEHAV BRAIN RES, V180, P69, DOI 10.1016/j.bbr.2007.02.036
   Hidese S, 2021, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.594394
   Hidese S, 2019, J AFFECT DISORDERS, V245, P213, DOI 10.1016/j.jad.2018.10.119
   Hidese S, 2018, PSYCHIAT CLIN NEUROS, V72, P513, DOI 10.1111/pcn.12656
   Hidese S, 2018, J PSYCHIATR RES, V102, P23, DOI 10.1016/j.jpsychires.2018.02.009
   Hidese S, 2018, J AFFECT DISORDERS, V225, P188, DOI 10.1016/j.jad.2017.08.028
   Hidese S, 2017, ACTA NEUROPSYCHIATR, V29, P72, DOI 10.1017/neu.2016.33
   Holick MF, 2007, NEW ENGL J MED, V357, P266, DOI 10.1056/NEJMra070553
   Hori H, 2016, J PSYCHIATR RES, V77, P27, DOI 10.1016/j.jpsychires.2016.02.022
   Igwe O, 2021, PROG NEURO-PSYCHOPH, V111, DOI 10.1016/j.pnpbp.2020.110206
   Ischaki Eleni, 2009, Ther Adv Respir Dis, V3, P31, DOI 10.1177/1753465809102662
   Ishii T, 2018, BIOCHEM BIOPH RES CO, V497, P683, DOI 10.1016/j.bbrc.2018.02.131
   Jacka FN, 2009, AUST NZ J PSYCHIAT, V43, P45, DOI 10.1080/00048670802534408
   Jelsma EB, 2021, PSYCHOPHYSIOLOGY, V58, DOI 10.1111/psyp.13763
   Jha MK, 2018, J AFFECT DISORDERS, V234, P34, DOI 10.1016/j.jad.2018.02.089
   Juul F, 2022, AM J CLIN NUTR, V115, P211, DOI 10.1093/ajcn/nqab305
   Kalinic D, 2014, CROAT MED J, V55, P27, DOI 10.3325/cmj.2014.55.27
   Kang D, 2018, EUR J CLIN NUTR, V72, P1506, DOI 10.1038/s41430-018-0121-2
   Kashi SK, 2023, BIOL RES NURS, V25, P88, DOI 10.1177/10998004221120945
   Kaviani M, 2020, J AFFECT DISORDERS, V269, P28, DOI 10.1016/j.jad.2020.03.029
   Kawakami N, 1999, DIABETES CARE, V22, P1071, DOI 10.2337/diacare.22.7.1071
   Kharel M, 2022, BMJ GLOB HEALTH, V7, DOI 10.1136/bmjgh-2021-007190
   Khoraminya N, 2013, AUST NZ J PSYCHIAT, V47, P271, DOI 10.1177/0004867412465022
   Kisely S, 2016, J AFFECT DISORDERS, V200, P119, DOI 10.1016/j.jad.2016.04.040
   Kito K, 2019, J HUM NUTR DIET, V32, P349, DOI 10.1111/jhn.12640
   Koga N., 2013, NEW DIET THERAPY, V29, P31
   Koga N, 2022, NEUROPSYCHOPHARM REP, V42, P457, DOI 10.1002/npr2.12285
   Koga N, 2019, TRANSL PSYCHIAT, V9, DOI 10.1038/s41398-019-0536-0
   Kogirima M., 2017, TRACE NUTR RES, V34, P102
   Kok JLA, 2015, INT J NURS STUD, V52, P1625, DOI 10.1016/j.ijnurstu.2015.05.012
   Kunugi H, 2022, PROG BRAIN RES, V270, P123, DOI 10.1016/bs.pbr.2022.01.023
   Kunugi H, 2021, ANN NUTR METAB, V77, P11, DOI 10.1159/000518274
   Kunugi H, 2015, PSYCHIAT CLIN NEUROS, V69, P597, DOI 10.1111/pcn.12299
   Kunugi H, 2010, PSYCHIAT CLIN NEUROS, V64, P447, DOI 10.1111/j.1440-1819.2010.02135.x
   Kvam S, 2016, J AFFECT DISORDERS, V202, P67, DOI 10.1016/j.jad.2016.03.063
   Lal S, 2001, AM J PHYSIOL-GASTR L, V281, pG907, DOI 10.1152/ajpgi.2001.281.4.G907
   Lang Florian, 2019, Neurosignals, V27, P40, DOI 10.33594/000000182
   Lansdowne ATG, 1998, PSYCHOPHARMACOLOGY, V135, P319, DOI 10.1007/s002130050517
   Lassale C, 2019, MOL PSYCHIATR, V24, P965, DOI 10.1038/s41380-018-0237-8
   Tomé AL, 2021, ACTAS ESP PSIQUIATRI, V49, P12
   Lerman C, 1998, HEALTH PSYCHOL, V17, P56, DOI 10.1037/0278-6133.17.1.56
   Li F, 2016, J EPIDEMIOL COMMUN H, V70, P299, DOI 10.1136/jech-2015-206278
   Li JD, 2020, ADDICTION, V115, P1224, DOI 10.1111/add.14935
   Li Y, 2020, BRIT J NUTR, V123, P1290, DOI 10.1017/S0007114520000562
   Liao YH, 2019, TRANSL PSYCHIAT, V9, DOI 10.1038/s41398-019-0515-5
   Lin PY, 2010, BIOL PSYCHIAT, V68, P140, DOI 10.1016/j.biopsych.2010.03.018
   Liu ML, 2016, BRIT J SPORT MED, V50, P1252, DOI 10.1136/bjsports-2015-095084
   Loh HH, 2021, DIABETES-METAB RES, V37, DOI 10.1002/dmrr.3458
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Lutter M, 2008, J NEUROSCI, V28, P3071, DOI 10.1523/JNEUROSCI.5584-07.2008
   Ma XM, 2020, OBES RES CLIN PRACT, V14, P1, DOI 10.1016/j.orcp.2019.12.002
   da Silva LEM, 2021, NUTR REV, V79, P1, DOI 10.1093/nutrit/nuaa039
   MAES M, 1994, J AFFECT DISORDERS, V31, P135, DOI 10.1016/0165-0327(94)90117-1
   Malmir H, 2023, NUTR NEUROSCI, V26, P807, DOI 10.1080/1028415X.2022.2094856
   Manchishi SM, 2018, J CELL MOL MED, V22, P2528, DOI 10.1111/jcmm.13418
   Mannan M, 2016, ASIAN J PSYCHIATR, V21, P51, DOI 10.1016/j.ajp.2015.12.008
   Matsuno H, 2022, MOL PSYCHIATR, V27, P3822, DOI 10.1038/s41380-022-01618-3
   Mazloomi SN, 2023, NUTR NEUROSCI, V26, P913, DOI 10.1080/1028415X.2022.2110188
   McIntyre RS, 2013, BEHAV BRAIN RES, V237, P164, DOI 10.1016/j.bbr.2012.09.021
   McRae MP, 2020, J CHIROPR MED, V19, P58, DOI 10.1016/j.jcm.2019.10.008
   Melchionda D, 2018, NUTR NEUROSCI, V21, P373, DOI [10.1080/1028415X.2017.1293761, 10.1080/1028415x.2017.1293761]
   Meyer N, 2022, LANCET, V400, P1061, DOI 10.1016/S0140-6736(22)00877-7
   Milaneschi Yuri, 2019, Mol Psychiatry, V24, P18, DOI 10.1038/s41380-018-0017-5
   Milano W, 2020, DISEASES-BASEL, V8, DOI 10.3390/diseases8020023
   Miller AL, 2008, ALTERN MED REV, V13, P216
   Miller AH, 2009, BIOL PSYCHIAT, V65, P732, DOI 10.1016/j.biopsych.2008.11.029
   Miller AH, 2009, BRAIN BEHAV IMMUN, V23, P149, DOI 10.1016/j.bbi.2008.08.006
   Ministry of Health, 2017, LAB WELF
   Mizoue T, 2015, J NUTR, V145, P541, DOI 10.3945/jn.114.204115
   Mizui T, 2019, J PSYCHIATR RES, V113, P190, DOI 10.1016/j.jpsychires.2019.03.024
   Molendijk M, 2018, J AFFECT DISORDERS, V226, P346, DOI 10.1016/j.jad.2017.09.022
   Mozaffarian D, 2011, J AM COLL CARDIOL, V58, P2047, DOI 10.1016/j.jacc.2011.06.063
   Munce SEP, 2006, J PSYCHOSOM RES, V61, P653, DOI 10.1016/j.jpsychores.2006.03.048
   Nakaji S, 2002, EUR J NUTR, V41, P222, DOI 10.1007/s00394-002-0379-x
   Nanri A, 2010, EUR J CLIN NUTR, V64, P832, DOI 10.1038/ejcn.2010.86
   Nanri A, 2010, EUR J CLIN NUTR, V64, P289, DOI 10.1038/ejcn.2009.143
   Nechita F, 2015, ROM J MORPHOL EMBRYO, V56, P949
   Nestler EJ., 2009, MOL NEUROPHARMACOL, P148
   Ng QX, 2017, J AFFECT DISORDERS, V210, P211, DOI 10.1016/j.jad.2016.12.048
   Pham NM, 2014, PUBLIC HEALTH NUTR, V17, P625, DOI 10.1017/S1368980013000360
   Nibber A, 2022, J AFFECT DISORDERS, V310, P52, DOI 10.1016/j.jad.2022.04.156
   Norregaard L, 1998, EMBO J, V17, P4266, DOI 10.1093/emboj/17.15.4266
   Noseworthy MD, 2000, P SOC EXP BIOL MED, V223, P175, DOI 10.1046/j.1525-1373.2000.22324.x
   Numakawa T, 2014, FRONT PSYCHIATRY, V5, DOI 10.3389/fpsyt.2014.00136
   Ogawa S, 2019, J AFFECT DISORDERS, V255, P182, DOI 10.1016/j.jad.2019.04.028
   Ogawa S, 2018, J PSYCHIATR RES, V105, P137, DOI 10.1016/j.jpsychires.2018.08.028
   Ogawa S, 2018, PSYCHOPHARMACOLOGY, V235, P37, DOI 10.1007/s00213-017-4743-1
   Ogawa S, 2018, J PSYCHIATR RES, V96, P23, DOI 10.1016/j.jpsychires.2017.09.014
   Ogawa S, 2014, J CLIN PSYCHIAT, V75, pE906, DOI 10.4088/JCP.13r08908
   Oike Hideaki, 2014, Curr Nutr Rep, V3, P204
   Okada C, 2019, J OBES, V2019, DOI 10.1155/2019/2439571
   Okereke OI, 2020, JAMA-J AM MED ASSOC, V324, P471, DOI 10.1001/jama.2020.10224
   Opie RS, 2017, NUTR NEUROSCI, V20, P161, DOI 10.1179/1476830515Y.0000000043
   Otaka M, 2021, MICROORGANISMS, V9, DOI 10.3390/microorganisms9051026
   PAFFENBARGER RS, 1994, ACTA PSYCHIAT SCAND, V89, P16, DOI 10.1111/j.1600-0447.1994.tb05796.x
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pandi-Perumal SR, 2020, PSYCHIAT RES, V291, DOI 10.1016/j.psychres.2020.113239
   Pasco JA, 2008, BRIT J PSYCHIAT, V193, P322, DOI 10.1192/bjp.bp.107.046706
   Pearce M, 2022, JAMA PSYCHIAT, V79, P550, DOI 10.1001/jamapsychiatry.2022.0609
   Pemberton R, 2016, J AFFECT DISORDERS, V200, P103, DOI 10.1016/j.jad.2016.04.023
   Peng LY, 2007, PEDIATR RES, V61, P37, DOI 10.1203/01.pdr.0000250014.92242.f3
   Perrault AA, 2019, SLEEP, V42, DOI 10.1093/sleep/zsz125
   Peter LJ, 2022, ACTAS ESP PSIQUIATRI, V50, P126
   Plante DT, 2021, AM J PSYCHIAT, V178, P896, DOI 10.1176/appi.ajp.2021.21080821
   Resler G, 2008, NEUROIMMUNOMODULAT, V15, P145, DOI 10.1159/000151527
   Riazi K, 2008, P NATL ACAD SCI USA, V105, P17151, DOI 10.1073/pnas.0806682105
   Ribeiro G, 2022, CURR OPIN CLIN NUTR, V25, P443, DOI 10.1097/MCO.0000000000000874
   Rush AJ, 2018, AM J PSYCHIAT, V175, P1187, DOI 10.1176/appi.ajp.2018.18040398
   Rush AJ, 2006, NEW ENGL J MED, V354, P1231, DOI 10.1056/NEJMoa052963
   Ryu M.-S., 2020, Present Knowl. Nutr. Elev. Ed., VEleventh, P393, DOI [10.1016/B978-0-323-66162-1.00023-8, DOI 10.1016/B978-0-323-66162-1.00023-8]
   Sakamoto FL, 2019, PHARMACOL RES, V147, DOI 10.1016/j.phrs.2019.104395
   Sampasa-Kanyinga H, 2023, J SLEEP RES, V32, DOI 10.1111/jsr.13727
   Sarris J, 2018, EUR NEUROPSYCHOPHARM, V28, P1126, DOI 10.1016/j.euroneuro.2018.07.098
   Sarris J, 2016, AM J PSYCHIAT, V173, P575, DOI 10.1176/appi.ajp.2016.15091228
   Sasayama D, 2013, J PSYCHIATR RES, V47, P401, DOI 10.1016/j.jpsychires.2012.12.001
   Serretti A, 2010, J CLIN PSYCHIAT, V71, P1259, DOI 10.4088/JCP.09r05346blu
   Shang X, 2022, NUTRIENTS, V14, DOI 10.3390/nu14122482
   Shivappa N, 2014, PUBLIC HEALTH NUTR, V17, P1689, DOI 10.1017/S1368980013002115
   Singh RB, 2022, NUTRIENTS, V14, DOI 10.3390/nu14040898
   Soga Masashi, 2017, Prev Med Rep, V5, P92
   Stewart JC, 2009, BRAIN BEHAV IMMUN, V23, P936, DOI 10.1016/j.bbi.2009.04.011
   Stubbs B, 2018, EUR PSYCHIAT, V54, P124, DOI 10.1016/j.eurpsy.2018.07.004
   Sublette ME, 2011, J CLIN PSYCHIAT, V72, P1577, DOI 10.4088/JCP.10m06634
   Swardfager W, 2013, BIOL PSYCHIAT, V74, P872, DOI 10.1016/j.biopsych.2013.05.008
   Takebe N, 2021, DIABET METAB SYND OB, V14, P2065, DOI 10.2147/DMSO.S300250
   Takeda A, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17071149
   Takeda A, 2009, BRAIN RES REV, V62, P33, DOI 10.1016/j.brainresrev.2009.09.003
   Tangestani Hadith, 2020, Recent Pat Food Nutr Agric, V11, P235, DOI 10.2174/2212798411666200316152252
   Tanida M, 2005, NEUROSCI LETT, V389, P109, DOI 10.1016/j.neulet.2005.07.036
   Toups MSP, 2013, PSYCHOSOM MED, V75, P863, DOI 10.1097/PSY.0000000000000000
   Tsuchimine S, 2019, NEUROPSYCH DIS TREAT, V15, P2221, DOI 10.2147/NDT.S209023
   Tsujino N, 2013, FRONT BEHAV NEUROSCI, V7, DOI 10.3389/fnbeh.2013.00028
   Van der Does AJW, 2001, J AFFECT DISORDERS, V64, P107, DOI 10.1016/S0165-0327(00)00209-3
   van Praag H, 1999, P NATL ACAD SCI USA, V96, P13427, DOI 10.1073/pnas.96.23.13427
   Vrshek-Schallhorn S, 2015, J ABNORM PSYCHOL, V124, P918, DOI 10.1037/abn0000088
   Wakabayashi C, 2012, PSYCHOPHARMACOLOGY, V219, P1099, DOI 10.1007/s00213-011-2440-z
   Wang AK, 2018, SCHIZOPHRENIA BULL, V44, P75, DOI 10.1093/schbul/sbx035
   Wang X, 2019, BMC PUBLIC HEALTH, V19, DOI 10.1186/s12889-019-7904-9
   Wang XW, 2021, J AFFECT DISORDERS, V289, P144, DOI 10.1016/j.jad.2021.04.030
   Wassef A, 2019, J PSYCHOSOM OBST GYN, V40, P19, DOI 10.1080/0167482X.2018.1427725
   White MP, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-87675-0
   Wilson JE, 2020, PSYCHOL MED, V50, P2711, DOI 10.1017/S0033291719002800
   Wolters M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13041070
   Wootton RE, 2020, PSYCHOL MED, V50, P2435, DOI 10.1017/S0033291719002678
   Wu G, 2013, FRONT BEHAV NEUROSCI, V7, DOI 10.3389/fnbeh.2013.00010
   Yamamoto K, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.9436
   Yang YD, 2020, FRONT PSYCHOL, V11, DOI 10.3389/fpsyg.2020.01451
   Yi Y, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph191710512
   Yim CY, 2012, EUR PSYCHIAT, V27, P223, DOI 10.1016/j.eurpsy.2011.02.004
   Yoon HS, 2017, J CLIN PSYCHIAT, V78, pE947, DOI 10.4088/JCP.16m11144
   Yoshida S, 2009, PSYCHIAT CLIN NEUROS, V63, P65, DOI 10.1111/j.1440-1819.2008.01889.x
   Yu Q, 2022, SPORTS MED-OPEN, V8, DOI 10.1186/s40798-022-00529-5
   Zahedi H, 2022, NUTR NEUROSCI, V25, P1250, DOI 10.1080/1028415X.2020.1853411
   Zanetidou S, 2011, INT J GERIATR PSYCH, V26, P1209, DOI 10.1002/gps.2703
   Zeng L, 2022, ASIA PAC J CLIN NUTR, V31, P642, DOI 10.6133/apjcn.202212_31(4).0008
   Zhai L, 2015, DEPRESS ANXIETY, V32, P664, DOI 10.1002/da.22386
   Zhang YF, 2015, CURR NEUROPHARMACOL, V13, P536, DOI 10.2174/1570159X13666150326003852
   Zirpel L, 2001, JARO-J ASSOC RES OTO, V2, P180, DOI 10.1007/s101620010082
NR 220
TC 37
Z9 40
U1 8
U2 61
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1323-1316
EI 1440-1819
J9 PSYCHIAT CLIN NEUROS
JI Psychiatry Clin. Neurosci.
PD AUG
PY 2023
VL 77
IS 8
BP 420
EP 433
DI 10.1111/pcn.13551
EA APR 2023
PG 14
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA O1HI0
UT WOS:000974734700001
PM 36992617
OA Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Min, SH
   Yang, Q
   Docherty, SL
   Im, EO
   Hu, X
AF Min, Se Hee
   Yang, Qing
   Docherty, Sharron L.
   Im, Eun-Ok
   Hu, Xiao
TI Symptom Clusters and Key Symptoms Among Midlife Perimenopausal and
   Postmenopausal Women With and Without Metabolic Syndrome
SO NURSING RESEARCH
LA English
DT Article
DE menopause; obesity; quality of life; symptom management; women's health
ID MENOPAUSAL TRANSITION; NETWORK ANALYSIS; SEXUAL FUNCTION; PREVALENCE;
   ASSOCIATION; DYSFUNCTION; DEPRESSION; ANXIETY; COHORT; HEALTH
AB Background Midlife perimenopausal and postmenopausal women with metabolic syndrome experience multiple symptoms concurrently. Objective The study objectives were to examine the relationship among symptoms through network visualization and identify and compare symptom clusters and key symptoms across symptom occurrence and symptom severity dimensions in midlife perimenopausal and postmenopausal women with and without metabolic syndrome. Methods Cross-sectional data from the Study of Women's Health Across the Nation (Visit 5) were used for analysis. A machine-learning-based network analysis and the Walktrap algorithm were used to fulfill the study objectives. Results The number and types of symptom clusters differed between the groups. Midlife perimenopausal and postmenopausal women with metabolic syndrome experienced the psychological/somatic/genital cluster (key symptom: frequent mood change), the sleep/urinary cluster (sleep disturbance), and the vasomotor cluster (cold sweat) in the symptom occurrence dimension and the psychological/somatic/sexual cluster (anxiety), the sleep/urinary cluster (sleep disturbance), and the vasomotor/genital cluster (night sweat) in the symptom severity dimension. In contrast, midlife perimenopausal and postmenopausal women without metabolic syndrome experienced the psychological cluster (anxiety), the sleep/somatic/genitourinary cluster (sleep disturbance), and the vasomotor cluster (night sweat) in the symptom occurrence dimension and the psychological/somatic cluster (anxiety), the sleep/urinary cluster (sleep disturbance), the vasomotor cluster (night sweat), and the sexual/genital cluster (vaginal dryness) in the symptom severity dimension. Discussion The study findings may serve as a knowledge basis for effective assessment and management of symptom clusters and key symptoms in clinical settings and provide directions for future development of targeted symptom management interventions.
C1 [Min, Se Hee; Yang, Qing; Docherty, Sharron L.] Duke Univ, Sch Nursing, 370 Trent Dr, Durham, NC 27705 USA.
   [Im, Eun-Ok; Hu, Xiao] Emory Univ, Sch Nursing, Atlanta, GA 30322 USA.
C3 Duke University; Emory University
RP Min, SH (corresponding author), Duke Univ, Sch Nursing, 370 Trent Dr, Durham, NC 27705 USA.
EM sehee.min@duke.edu; qing.yang@duke.edu; sharron.docherty@duke.edu;
   eun.ok.im@emory.edu; xiao.hu@duke.edu
RI Hu, Xiaoyu/AAO-2060-2020
OI Min, Se Hee/0000-0003-2722-6627; Yang, Qing/0000-0003-4844-4690
FU National Institute of Nursing Research of the National Institutes of
   Health [1F31NR019921-01]
FX Research reported in this publication was supported by the National
   Institute of Nursing Research of the National Institutes of Health under
   Award Number 1F31NR019921-01. The content is solely the authors'
   responsibility and does not necessarily represent the official views of
   the National Institutes of Health.
CR Almutary H, 2016, J ADV NURS, V72, P2389, DOI 10.1111/jan.12997
   Althof SE, 2013, ARAB J UROL, V11, P299, DOI 10.1016/j.aju.2013.04.010
   Bentley-Lewis R, 2007, NAT CLIN PRACT ENDOC, V3, P696, DOI 10.1038/ncpendmet0616
   Bromberger JT, 2011, PSYCHOL MED, V41, P1879, DOI 10.1017/S003329171100016X
   Bromberger JT, 2013, MENOPAUSE, V20, P488, DOI [10.1097/gme.0b013e3182730599, 10.1097/GME.0b013e3182730599]
   Bruce D, 2009, BEST PRACT RES CL OB, V23, P25, DOI 10.1016/j.bpobgyn.2008.10.002
   Christian C, 2020, J ABNORM PSYCHOL, V129, P177, DOI 10.1037/abn0000477
   Cosco TD, 2017, J NURS MEAS, V25, P476, DOI 10.1891/1061-3749.25.3.476
   Dalege J, 2017, SOC PSYCHOL PERS SCI, V8, P528, DOI 10.1177/1948550617709827
   de Marchi R, 2017, ARCH ENDOCRIN METAB, V61, P160, DOI 10.1590/2359-3997000000253
   da Silva GMD, 2020, SEX MED-UK, V8, P545, DOI 10.1016/j.esxm.2020.05.008
   Epskamp S, 2018, BEHAV RES METHODS, V50, P195, DOI 10.3758/s13428-017-0862-1
   Guicciardi M, 2019, FRONT PSYCHOL, V10, DOI 10.3389/fpsyg.2019.01845
   Hall MH, 2012, SLEEP, V35, P783, DOI 10.5665/sleep.1874
   Harlow Sioban D, 2017, Womens Midlife Health, V3, DOI 10.1186/s40695-017-0021-y
   Harlow Sioban D, 2015, Womens Midlife Health, V1, P5, DOI 10.1186/s40695-015-0006-7
   Heinemann Klaas, 2004, Health Qual Life Outcomes, V2, P45, DOI 10.1186/1477-7525-2-45
   Hevey D, 2018, HEALTH PSYCHOL BEHAV, V6, P301, DOI 10.1080/21642850.2018.1521283
   Kazlauskaite R, 2020, J CLIN ENDOCR METAB, V105, DOI 10.1210/clinem/dgaa067
   Kling JM, 2017, MENOPAUSE, V24, P604, DOI 10.1097/GME.0000000000000824
   Lee SW, 2012, ARCH GYNECOL OBSTET, V285, P541, DOI 10.1007/s00404-011-2016-5
   Martelli V, 2012, J SEX MED, V9, P434, DOI 10.1111/j.1743-6109.2011.02517.x
   Miaskowski Christine, 2004, J Natl Cancer Inst Monogr, P17
   Miaskowski C, 2016, SEMIN ONCOL NURS, V32, P405, DOI 10.1016/j.soncn.2016.08.006
   Min SH, 2022, WESTERN J NURS RES, V44, P838, DOI 10.1177/01939459211018824
   Mulhall S, 2018, MATURITAS, V108, P7, DOI 10.1016/j.maturitas.2017.11.005
   Papachristou N, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-36973-1
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Roohafza H, 2012, INT J ENDOCRINOL, V2012, DOI 10.1155/2012/380902
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Santoro N, 2011, OBSTET GYN CLIN N AM, V38, P455, DOI 10.1016/j.ogc.2011.05.004
   Shoelson SE, 2007, GASTROENTEROLOGY, V132, P2169, DOI 10.1053/j.gastro.2007.03.059
   Torréns JI, 2009, MENOPAUSE, V16, P257, DOI 10.1097/gme.0b013e318185e249
   van Borkulo CD, 2014, SCI REP-UK, V4, DOI 10.1038/srep05918
   Watts DJ, 1998, NATURE, V393, P440, DOI 10.1038/30918
   Yim G, 2015, MENOPAUSE, V22, P1108, DOI 10.1097/GME.0000000000000438
NR 36
TC 9
Z9 11
U1 2
U2 22
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0029-6562
EI 1538-9847
J9 NURS RES
JI Nurs. Res.
PD JUL-AUG
PY 2022
VL 71
IS 4
BP E28
EP E38
DI 10.1097/NNR.0000000000000591
PG 11
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 2J3FF
UT WOS:000815546700001
PM 35759720
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hall, CV
   Hepsomali, P
   Dalile, B
   Scapozza, L
   Gurry, T
AF Hall, Caitlin Victoria
   Hepsomali, Piril
   Dalile, Boushra
   Scapozza, Leonardo
   Gurry, Thomas
TI Effects of a diverse prebiotic fibre blend on inflammation, the gut
   microbiota and affective symptoms in metabolic syndrome: a pilot
   open-label randomised controlled trial
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Microbiota-gut-brain axis; Depression; Anxiety; Stress; High sensitivity
   C-reactive protein; Inflammation; Prebiotic fibre
ID ANXIETY STRESS SCALES; C-REACTIVE PROTEIN; HEALTHY-ADULTS; DIETARY
   FIBER; DOUBLE-BLIND; FATTY-ACIDS; DEPRESSION; METAANALYSIS; ASSOCIATION;
   SICKNESS
AB Emerging evidence suggests that low-grade systemic inflammation plays a key role in altering brain activity, behaviour and affect. Modulation of the gut microbiota using prebiotic fibre offers a potential therapeutic tool to regulate inflammation, mediated via the production of short-chain fatty acids (SCFA). However, the impact of prebiotic consumption on affective symptoms and the possible contribution from inflammation, gut symptoms and the gut microbiome are currently underexamined. In this 12-week study, the effects of a diverse prebiotic blend on inflammation, gut microbiota profiles and affective symptoms in a population with metabolic syndrome (MetS) were examined. Sixty males and females with MetS meeting the criteria for MetS were randomised into a treatment group (n 40), receiving 10 g per day of a diverse prebiotic blend and healthy eating advice, and a control group (n 20), receiving healthy eating advice only. Our results showed a significant reduction in high sensitivity C-reactive protein (hs-CRP) in the treatment (-0<middle dot>58 [-9<middle dot>96 to-2<middle dot>63]) compared with control (0<middle dot>37 [-3<middle dot>64 to-3<middle dot>32]), alongside significant improvements in self-reported affective scores in the treatment compared with the control group. While there were no differences in relative abundance between groups at week 12, there was a significant increase from baseline to week 12 in fecal Bifidobacterium and Parabacteroides in the treatment group, both of which are recognised as SCFA producers. Multivariate regression analyses further revealed an association between gastrointestinal symptoms and hs-CRP with affective scores. Together, this study provides preliminary support for a diverse prebiotic blend for mood, stress and anxiety.
C1 [Hall, Caitlin Victoria; Gurry, Thomas] Myota Ltd, London, England.
   [Hepsomali, Piril] Univ Reading, Sch Psychol & Clin Language Sci, Reading, England.
   [Dalile, Boushra] Katholieke Univ Leuven, Fac Med, Translat Res Ctr Gastrointestinal Disorders TARGID, Dept Chron Dis & Metab, Leuven, Belgium.
   [Dalile, Boushra] Katholieke Univ Leuven, Leuven Brain Inst, Leuven, Belgium.
   [Dalile, Boushra] Katholieke Univ Leuven, Fac Psychol & Educ Sci, Lab Biol Psychol Brain & Cognit, Leuven, Belgium.
   [Scapozza, Leonardo; Gurry, Thomas] Univ Geneva, Sch Pharmaceut Sci, Pharmaceut Biochem Grp, Geneva, Switzerland.
C3 University of Reading; KU Leuven; KU Leuven; KU Leuven; University of
   Geneva
RP Hepsomali, P (corresponding author), Univ Reading, Sch Psychol & Clin Language Sci, Reading, England.
EM p.hepsomali@reading.ac.uk
RI Scapozza, Leonardo/W-5278-2018; Dalile, Boushra/AAM-4680-2020;
   Hepsomali, Piril/ABC-1260-2021
OI Twelves, John Luke/0009-0001-9137-9727
FU Myota GmbH
FX This project was sponsored and funded by Myota GmbH.
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Amir A, 2017, MSYSTEMS, V2, DOI 10.1128/mSystems.00191-16
   Antony MM, 1998, PSYCHOL ASSESSMENT, V10, P176, DOI 10.1037/1040-3590.10.2.176
   Aruldass AR, 2021, BRAIN BEHAV IMMUN, V98, P299, DOI 10.1016/j.bbi.2021.08.226
   Azpiroz F, 2017, NEUROGASTROENT MOTIL, V29, DOI 10.1111/nmo.12911
   Bell JA, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/tp.2017.155
   Berding K, 2021, PSYCHOPHARMACOLOGY, V238, P149, DOI 10.1007/s00213-020-05665-y
   Bolyen E, 2019, NAT BIOTECHNOL, V37, P852, DOI 10.1038/s41587-019-0209-9
   Bonaz B, 2018, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00049
   Bullmore E., 2018, The Inflamed Mind: A radical new approach to depression
   Caporaso JG, 2012, ISME J, V6, P1621, DOI 10.1038/ismej.2012.8
   Cen MQ, 2024, BRAIN BEHAV IMMUN, V116, P1, DOI 10.1016/j.bbi.2023.11.019
   Chan KL, 2019, PHYSIOLOGY, V34, P123, DOI 10.1152/physiol.00047.2018
   Chang PV, 2014, P NATL ACAD SCI USA, V111, P2247, DOI 10.1073/pnas.1322269111
   Childs CE, 2014, BRIT J NUTR, V111, P1945, DOI 10.1017/S0007114513004261
   Costabile A, 2010, BRIT J NUTR, V104, P1007, DOI 10.1017/S0007114510001571
   Crawford JR, 2003, BRIT J CLIN PSYCHOL, V42, P111, DOI 10.1348/014466503321903544
   Cryan JF, 2019, PHYSIOL REV, V99, P1877, DOI 10.1152/physrev.00018.2018
   Dalile B, 2024, PROG NEURO-PSYCHOPH, V131, DOI 10.1016/j.pnpbp.2024.110939
   Dalile B, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.896154
   Dalile B, 2020, NEUROPSYCHOPHARMACOL, V45, P2257, DOI 10.1038/s41386-020-0732-x
   Dalile B, 2019, NAT REV GASTRO HEPAT, V16, P461, DOI 10.1038/s41575-019-0157-3
   DANTZER R, 1989, LIFE SCI, V44, P1995, DOI 10.1016/0024-3205(89)90345-7
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   Dantzer R, 2007, BRAIN BEHAV IMMUN, V21, P153, DOI 10.1016/j.bbi.2006.09.006
   DeSantis TZ, 2006, APPL ENVIRON MICROB, V72, P5069, DOI 10.1128/AEM.03006-05
   Felger JC, 2020, MOL PSYCHIATR, V25, P1301, DOI 10.1038/s41380-018-0096-3
   Fuller S, 2016, PLANT FOOD HUM NUTR, V71, P1, DOI 10.1007/s11130-016-0529-6
   Gibson GR, 2004, NUTR RES REV, V17, P259, DOI 10.1079/NRR200479
   Gurry T, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0254004
   Hall CV, 2024, BRIT J NUTR, V132, P68, DOI [10.1017/S0007114524000904, 10.1017/S0007114524002186]
   Hall CV., 2024, MEDRXIV, V2001
   Harrison NA, 2009, BIOL PSYCHIAT, V66, P415, DOI 10.1016/j.biopsych.2009.03.007
   Hepsomali P, 2022, ADV CLIN EXP MED, V31, P821, DOI 10.17219/acem/152350
   Hepsomali P, 2022, J PSYCHOPHARMACOL, V36, P1077, DOI 10.1177/02698811221112932
   Imam SS, 2008, INT J BEHAV SCI, V3, P104
   Jacka FN, 2017, BMC MED, V15, DOI 10.1186/s12916-017-0791-y
   Jiao J, 2015, INT J FOOD SCI NUTR, V66, P114, DOI 10.3109/09637486.2014.959898
   Katcher HI, 2008, AM J CLIN NUTR, V87, P79, DOI 10.1093/ajcn/87.1.79
   Kitzbichler MG, 2021, MOL PSYCHIATR, V26, P7346, DOI 10.1038/s41380-021-01272-1
   Knitza J, 2022, ARTHRITIS RES THER, V24, DOI 10.1186/s13075-022-02809-7
   Köhler-Forsberg O, 2017, BRAIN BEHAV IMMUN, V62, P344, DOI 10.1016/j.bbi.2017.02.020
   La Torre Danique, 2021, Gut Microbiome (Camb), V2, pe3, DOI 10.1017/gmb.2021.3
   Lal S, 2001, AM J PHYSIOL-GASTR L, V281, pG907, DOI 10.1152/ajpgi.2001.281.4.G907
   Lee EH, 2012, ASIAN NURS RES, V6, P121, DOI 10.1016/j.anr.2012.08.004
   Malaguarnera M, 2012, DIGEST DIS SCI, V57, P545, DOI 10.1007/s10620-011-1887-4
   Mallick H, 2021, PLOS COMPUT BIOL, V17, DOI 10.1371/journal.pcbi.1009442
   McLoughlin RF, 2017, AM J CLIN NUTR, V106, P930, DOI 10.3945/ajcn.117.156265
   Mysonhimer AR, 2023, J NUTR, V153, P1283, DOI 10.1016/j.tjnut.2023.02.015
   Nwankwo L, 2021, BMJ OPEN QUAL, V10, DOI 10.1136/bmjoq-2020-001192
   Oh EG, 2013, BIOL RES NURS, V15, P48, DOI 10.1177/1099800411416637
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pelaseyed T, 2014, IMMUNOL REV, V260, P8, DOI 10.1111/imr.12182
   Potrykus M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13113839
   Qu H, 2021, CURR MED CHEM, V28, P419, DOI 10.2174/0929867327666191230110128
   Ravi RK, 2018, METHODS MOL BIOL, V1706, P223, DOI 10.1007/978-1-4939-7471-9_12
   Rijnaarts I, 2021, J HUM NUTR DIET, V34, P969, DOI 10.1111/jhn.12941
   ROEDIGER WEW, 1982, GASTROENTEROLOGY, V83, P424
   ROEDIGER WEW, 1980, GUT, V21, P793, DOI 10.1136/gut.21.9.793
   Schmidt K, 2015, PSYCHOPHARMACOLOGY, V232, P1793, DOI 10.1007/s00213-014-3810-0
   Schneider EE, 2020, INT J CLIN HLTH PSYC, V20, P173, DOI 10.1016/j.ijchp.2020.03.004
   Schrepf A, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-04648-0
   Shinkov A, 2018, POSTGRAD MED, V130, P251, DOI 10.1080/00325481.2018.1410054
   Silk DBA, 2009, ALIMENT PHARM THER, V29, P508, DOI 10.1111/j.1365-2036.2008.03911.x
   Soliman ML, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-51
   Spitzer RL, 1999, JAMA-J AM MED ASSOC, V282, P1737, DOI 10.1001/jama.282.18.1737
   Spitzer RL, 2006, ARCH INTERN MED, V166, P1092, DOI 10.1001/archinte.166.10.1092
   SVEDLUND J, 1988, DIGEST DIS SCI, V33, P129, DOI 10.1007/BF01535722
   Tang F, 2017, PSYCHONEUROENDOCRINO, V77, P112, DOI 10.1016/j.psyneuen.2016.11.025
   van de Wouw M, 2018, J PHYSIOL-LONDON, V596, P4923, DOI 10.1113/JP276431
   Waldecker M, 2008, J NUTR BIOCHEM, V19, P587, DOI 10.1016/j.jnutbio.2007.08.002
   Yin WY, 2021, INT J BEHAV NUTR PHY, V18, DOI 10.1186/s12966-021-01227-3
   Yun QP, 2024, ECLINICALMEDICINE, V67, DOI 10.1016/j.eclinm.2023.102371
NR 73
TC 3
Z9 3
U1 5
U2 7
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD OCT 28
PY 2024
VL 132
IS 8
BP 1002
EP 1013
DI 10.1017/S0007114524002186
EA OCT 2024
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA N4N0B
UT WOS:001332679800001
PM 39411833
OA hybrid
DA 2025-06-11
ER

PT J
AU Jung, SJ
   Woo, HT
   Cho, S
   Park, K
   Jeong, S
   Lee, YJ
   Kang, D
   Shin, A
AF Jung, Sun Jae
   Woo, Hyung-Taek
   Cho, Sooyoung
   Park, Kyounghoon
   Jeong, Seokhun
   Lee, Yu Jin
   Kang, Daehee
   Shin, Aesun
TI Association between body size, weight change and depression: systematic
   review and meta-analysis
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Review
ID LOW-BIRTH-WEIGHT; POSTTRAUMATIC-STRESS-DISORDER; LIFE-STYLE FACTORS;
   7-YEAR FOLLOW-UP; MASS INDEX; METABOLIC SYNDROME; MAJOR DEPRESSION;
   MENTAL-HEALTH; SELF-ESTEEM; ADOLESCENT DEPRESSION
AB Background
   The association between body size, weight change and depression has not been systematically summarised, especially for individuals who are underweight.
   Aims
   To conduct a systematic review and a meta-analysis to examine the association between indices of body size, weight change and depression.
   Method
   A total of 183 studies were selected. Fully adjusted hazard ratios (HRs) or odds ratios (ORs) were extracted. A total of 76 studies contributed to data synthesis with a random-effect model, and subgroup analyses were conducted to evaluate the effect of potential moderators.
   Results
   In cohort studies, underweight at baseline increased the risk of subsequent depression (OR = 1.16, 95% Cl 1.08-1.24). Overweight (BMI 25-29.9 kg/m(2)) showed no statistically significant relationship with depression overall; however, the subgroup analyses found different results according to gender (men: OR = 0.84, 95% Cl 0.72-0.97, women: OR = 1.16, 95% Cl 1.07-1.25). In cross-sectional designs, obesity with BMI >40 kg/m(2) showed a greater pooled odds ratio than obesity with BMI >30 kg/m(2).
   Conclusions
   Both underweight and obesity increase the risk of depression. The association between overweight and depression differs by gender.
C1 [Jung, Sun Jae] Seoul Natl Univ, Coll Med, Dept Biomed Sci, Seoul, South Korea.
   [Woo, Hyung-Taek; Cho, Sooyoung; Park, Kyounghoon; Jeong, Seokhun; Shin, Aesun] Seoul Natl Univ, Coll Med, Dept Prevent Med, 103 Daehak Ro, Seoul 03080, South Korea.
   [Lee, Yu Jin] Seoul Natl Univ Hosp, Dept Psychiat, Seoul, South Korea.
   [Kang, Daehee] Seoul Natl Univ, Coll Med, Dept Prevent Med, Dept Biomed Sci, Seoul, South Korea.
   [Kang, Daehee; Shin, Aesun] Seoul Natl Univ, Canc Res Inst, Seoul, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU); Seoul
   National University (SNU); Seoul National University Hospital; Seoul
   National University (SNU); Seoul National University (SNU)
RP Shin, A (corresponding author), Seoul Natl Univ, Coll Med, Dept Prevent Med, 103 Daehak Ro, Seoul 03080, South Korea.
EM shinaesun@sun.ac.kr
RI Shin, Aesun/E-9145-2014; Kang, Dae/E-8631-2012; Jung, Sun/O-5372-2019;
   Jung, Sun Jae/D-5620-2011
OI Jung, Sun Jae/0000-0002-5194-7339; Kang, Daehee/0000-0003-4031-5878;
   Park, Kyounghoon/0000-0001-5800-917X
FU SNUH Research Fund [23-2015-0010]
FX This study was supported by grant 23-2015-0010 from the SNUH Research
   Fund.
CR Abdus S, 2014, J BEHAV HLTH SERVICE
   Abou Abbas L, 2015, CLIN OBES, V5, P2, DOI 10.1111/cob.12082
   Accurso EC, 2014, BEHAV RES THER, V56, P1, DOI 10.1016/j.brat.2014.02.006
   Ahola AJ, 2010, ANN MED, V42, P495, DOI 10.3109/07853890.2010.503660
   Akbaraly TN, 2009, DIABETES CARE, V32, P499, DOI 10.2337/dc08-1358
   Almeida OP, 2009, AM J GERIAT PSYCHIAT, V17, P889, DOI 10.1097/JGP.0b013e3181b047e3
   Anderson SE, 2007, PSYCHOSOM MED, V69, P740, DOI 10.1097/PSY.0b013e31815580b4
   Anderson SE, 2011, INT J PEDIATR OBES, V6, P69, DOI 10.3109/17477161003728477
   Angstman KB, 2013, J PRIM CARE COMMUNIT, V4, P119, DOI 10.1177/2150131912454012
   Annesi JJ, 2011, J COMPLEMENTARY INT, P8
   Asghar S, 2010, OBESITY, V18, P1143, DOI 10.1038/oby.2009.332
   Atlantis E, 2008, INT J OBESITY, V32, P715, DOI 10.1038/sj.ijo.0803762
   Barber J, 2011, MIL MED, V176, P151, DOI 10.7205/MILMED-D-09-00275
   Batty GD, 2010, AM J EPIDEMIOL, V172, P890, DOI 10.1093/aje/kwq274
   Beck NN, 2012, EAT BEHAV, V13, P394, DOI 10.1016/j.eatbeh.2012.06.001
   Bell LM, 2007, J CLIN ENDOCR METAB, V92, P517, DOI 10.1210/jc.2006-1714
   Berner LA, 2013, J ABNORM PSYCHOL, V122, P694, DOI 10.1037/a0033930
   Beydoun MA, 2010, J AFFECT DISORDERS, V123, P52, DOI 10.1016/j.jad.2009.09.021
   Beydoun MA, 2009, AM J CLIN NUTR, V90, P1084, DOI 10.3945/ajcn.2009.27782
   Bjerkeset O, 2008, AM J EPIDEMIOL, V167, P193, DOI 10.1093/aje/kwm280
   Blaine B, 2008, J HEALTH PSYCHOL, V13, P1190, DOI 10.1177/1359105308095977
   Blümel JE, 2015, MATURITAS, V80, P100, DOI 10.1016/j.maturitas.2014.10.007
   Boutelle KN, 2010, HEALTH PSYCHOL, V29, P293, DOI 10.1037/a0018645
   Brewer-Smyth K, 2014, REHABIL NURS, V39, P183, DOI 10.1002/rnj.150
   Bromberger JT, 2009, PSYCHOL MED, V39, P55, DOI 10.1017/S0033291708003218
   Brunault P, 2012, PSYCHOSOMATICS, V53, P363, DOI 10.1016/j.psym.2011.12.008
   Burgmer R, 2014, OBES SURG, V24, P1670, DOI 10.1007/s11695-014-1226-x
   Carey M, 2014, BRIT J GEN PRACT, V64, pE122, DOI 10.3399/bjgp14X677482
   Carpenter KM, 2000, AM J PUBLIC HEALTH, V90, P251, DOI 10.2105/AJPH.90.2.251
   Chang HH, 2012, AGING MENT HEALTH, V16, P173, DOI 10.1080/13607863.2011.605053
   Chen Y, 2009, J WOMENS HEALTH, V18, P1687, DOI 10.1089/jwh.2008.1175
   Chwastiak LA, 2011, PSYCHOSOMATICS, V52, P230, DOI 10.1016/j.psym.2010.12.009
   Cornette R, 2008, WORLDV EVID-BASED NU, V5, P136, DOI 10.1111/j.1741-6787.2008.00127.x
   Costello EJ, 2007, ARCH GEN PSYCHIAT, V64, P338, DOI 10.1001/archpsyc.64.3.338
   CRISP AH, 1976, BRIT MED J, V1, P7, DOI 10.1136/bmj.1.6000.7
   Dave DM, 2011, J MENT HEALTH POLICY, V14, P165
   de Mola CL, 2014, BRIT J PSYCHIAT, V205, P340, DOI 10.1192/bjp.bp.113.139014
   de Wit L, 2010, PSYCHIAT RES, V178, P230, DOI 10.1016/j.psychres.2009.04.015
   de Zwaan M, 2011, J AFFECT DISORDERS, V133, P61, DOI 10.1016/j.jad.2011.03.025
   DIPIETRO L, 1992, INT J OBESITY, V16, P745
   Dixon JB, 2014, DIABETIC MED, V31, P232, DOI 10.1111/dme.12306
   Dong C, 2004, INT J OBESITY, V28, P790, DOI 10.1038/sj.ijo.0802626
   Dortland AKBV, 2013, PSYCHOSOM MED, V75, P83, DOI 10.1097/PSY.0b013e318274d30f
   Egede LE, 2003, DIABETES CARE, V26, P104, DOI 10.2337/diacare.26.1.104
   Egger M, 1997, BMJ-BRIT MED J, V315, P629, DOI 10.1136/bmj.315.7109.629
   Faith MS, 2011, OBES REV, V12, pe438, DOI 10.1111/j.1467-789X.2010.00843.x
   Franko DL, 2005, PSYCHOL MED, V35, P1505, DOI 10.1017/S0033291705005386
   Frisco ML, 2013, AM J EPIDEMIOL, V178, P22, DOI 10.1093/aje/kws462
   Frisco ML, 2010, J HEALTH SOC BEHAV, V51, P215, DOI 10.1177/0022146510372353
   Gale CR, 2004, BRIT J PSYCHIAT, V184, P28, DOI 10.1192/bjp.184.1.28
   Gariepy G, 2010, OBESITY, V18, P1033, DOI 10.1038/oby.2009.333
   Gaskin JL, 2013, J AFFECT DISORDERS, V150, P350, DOI 10.1016/j.jad.2013.04.017
   Gavin AR, 2010, J PSYCHOSOM RES, V69, P573, DOI 10.1016/j.jpsychores.2010.05.001
   Gavin AR, 2010, PUBLIC HEALTH REP, V125, P698, DOI 10.1177/003335491012500512
   Gazmararian J, 2000, ARCH INTERN MED, V160, P3307, DOI 10.1001/archinte.160.21.3307
   Gearhardt AN, 2012, DRUG ALCOHOL DEPEN, V124, P185, DOI 10.1016/j.drugalcdep.2012.01.002
   Geoffroy MC, 2014, PSYCHOL MED, V44, P2641, DOI 10.1017/S0033291714000142
   Goldney RD, 2009, AUST NZ J PSYCHIAT, V43, P652, DOI 10.1080/00048670902970825
   Goodman E, 2011, J ADOLESCENT HEALTH, V49, P64, DOI 10.1016/j.jadohealth.2010.10.015
   Grundy A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0099780
   Guruprasad K G, 2012, Indian J Psychol Med, V34, P30, DOI 10.4103/0253-7176.96153
   Halfon N, 2013, ACAD PEDIATR, V13, P6, DOI 10.1016/j.acap.2012.10.007
   Hamer M, 2012, MOL PSYCHIATR, V17, P940, DOI 10.1038/mp.2012.30
   Heidelberg DA, 2011, HEALTH QUAL LIFE OUT, V9, DOI 10.1186/1477-7525-9-97
   Heo M, 2006, INT J OBESITY, V30, P513, DOI 10.1038/sj.ijo.0803122
   Herva A, 2006, INT J OBESITY, V30, P520, DOI 10.1038/sj.ijo.0803174
   Higgins JP, 2003, BMJ (Clinical research ed), V327, P557, DOI DOI 10.1136/BMJ.327.7414.557
   Hillman JB, 2010, CLIN PEDIATR, V49, P671, DOI 10.1177/0009922810363155
   Ho RCM, 2008, INT J GERIATR PSYCH, V23, P401, DOI 10.1002/gps.1893
   Holme AR, 2013, BMJ OPEN, P3
   Hooker SA, 2014, CLIN OBES, V4, P21, DOI 10.1111/cob.12035
   Ivarsson Tord, 2006, Eat Behav, V7, P161, DOI 10.1016/j.eatbeh.2005.08.005
   Jéquier E, 2002, ANN NY ACAD SCI, V967, P379, DOI 10.1111/j.1749-6632.2002.tb04293.x
   Jorm AF, 2003, AUST NZ J PUBL HEAL, V27, P434, DOI 10.1111/j.1467-842X.2003.tb00423.x
   Joseph Nitin, 2013, Indian J Endocrinol Metab, V17, P681, DOI 10.4103/2230-8210.113761
   Kabir AA, 2006, AM J HYPERTENS, V19, P639, DOI 10.1016/j.amjhyper.2005.10.026
   Kapadia SG, 2014, RESP MED, V108, P1100, DOI 10.1016/j.rmed.2014.05.012
   Katon W, 2004, DIABETES CARE, V27, P914, DOI 10.2337/diacare.27.4.914
   Katon W, 2009, PSYCHOSOMATICS, V50, P570, DOI 10.1176/appi.psy.50.6.570
   Kawada T, 2011, WORK, V38, P123, DOI 10.3233/WOR-2011-1114
   Khuwaja AK, 2010, DIABETOL METAB SYNDR, V2, DOI 10.1186/1758-5996-2-72
   Kiefer I, 2000, SOZ PRAVENTIV MED, V45, P274, DOI 10.1007/BF01591690
   Kim Dong-Sik, 2008, J Prev Med Public Health, V41, P323, DOI 10.3961/jpmph.2008.41.5.323
   Kim E, 2010, ARCH GERONTOL GERIAT, V51, P231, DOI 10.1016/j.archger.2009.10.014
   Kim JY, 2010, J KOREAN MED SCI, V25, P1560, DOI 10.3346/jkms.2010.25.11.1560
   Kim J, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0114891
   Kim O, 2001, ADOLESCENCE, V36, P315
   Kim SY, 2013, J CLIN EPIDEMIOL, V66, P408, DOI 10.1016/j.jclinepi.2012.09.016
   Korczak DJ, 2014, J DEV BEHAV PEDIATR, V35, P108, DOI 10.1097/DBP.0000000000000015
   Kress AM, 2006, J PSYCHOSOM RES, V60, P263, DOI 10.1016/j.jpsychores.2005.08.011
   Kronish IM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0052771
   Kubzansky LD, 2012, ANN BEHAV MED, V43, P219, DOI 10.1007/s12160-011-9323-8
   Kuriyama S, 2006, J PSYCHOSOM RES, V60, P229, DOI 10.1016/j.jpsychores.2005.07.010
   Labad J, 2012, PSYCHOSOM MED, V74, P39, DOI 10.1097/PSY.0b013e31823ba8af
   Lanza HI, 2013, J PEDIATR PSYCHOL, V38, P376, DOI 10.1093/jpepsy/jss130
   Lasserre AM, 2014, JAMA PSYCHIAT, V71, P880, DOI 10.1001/jamapsychiatry.2014.411
   Lawlor DA, 2002, AGE AGEING, V31, P169, DOI 10.1093/ageing/31.3.169
   Lawson EA, 2012, CLIN ENDOCRINOL, V76, P520, DOI 10.1111/j.1365-2265.2011.04182.x
   Lee JI, 2014, KAOHSIUNG J MED SCI, V30, P625, DOI 10.1016/j.kjms.2014.09.005
   Lehto S, 2000, SCAND CARDIOVASC J, V34, P580
   Lehto SM, 2010, ACTA PSYCHIAT SCAND, V121, P209, DOI 10.1111/j.1600-0447.2009.01463.x
   Levine SZ, 2014, PSYCHIAT RES, V215, P618, DOI 10.1016/j.psychres.2014.01.008
   Li ZB, 2004, INT J GERIATR PSYCH, V19, P68, DOI 10.1002/gps.1040
   Lin FG, 2012, ASIA PAC J CLIN NUTR, V21, P64
   Lin KP, 2014, BIOL RES NURS, V16, P327, DOI 10.1177/1099800413500138
   Lincoln KD, 2014, J HEALTH CARE POOR U, V25, P257, DOI 10.1353/hpu.2014.0038
   Linde JA, 2004, INT J OBESITY, V28, P418, DOI 10.1038/sj.ijo.0802570
   Liu CS, 2014, CNS NEUROL DISORD-DR, V13, P1693
   Liu YX, 2014, PSYCHIAT RES, V219, P103, DOI 10.1016/j.psychres.2014.05.025
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Maguen S, 2013, J GEN INTERN MED, V28, pS563, DOI 10.1007/s11606-013-2374-8
   Mamalakis G, 2008, PHARMACOL BIOCHEM BE, V89, P6, DOI 10.1016/j.pbb.2007.10.015
   Marijnissen RM, 2013, J AFFECT DISORDERS, V151, P1138, DOI 10.1016/j.jad.2013.07.029
   Mather AA, 2009, J PSYCHOSOM RES, V66, P277, DOI 10.1016/j.jpsychores.2008.09.008
   Matziou V, 2010, PEDIATRIC REP, V2, P51, DOI 10.4081/pr.2010.e16
   McLaren L, 2008, SOC PSYCH PSYCH EPID, V43, P63, DOI 10.1007/s00127-007-0269-x
   Miettola J, 2008, SCAND J PRIM HEALTH, V26, P203, DOI 10.1080/02813430802117624
   Moran LJ, 2013, NUTRITION, V29, P1271, DOI 10.1016/j.nut.2013.03.023
   Morrison KM, 2015, J AFFECT DISORDERS, V172, P18, DOI 10.1016/j.jad.2014.09.014
   Moselhy HF, 2012, EPIDEMIOL PSYCH SCI, V21, P213, DOI 10.1017/S2045796011000709
   Murphy JM, 2009, INT J OBESITY, V33, P335, DOI 10.1038/ijo.2008.273
   Needham BL, 2010, AM J PUBLIC HEALTH, V100, P1040, DOI 10.2105/AJPH.2009.172809
   Nelson TL, 1999, OBES RES, V7, P199, DOI 10.1002/j.1550-8528.1999.tb00702.x
   Ohayon MM, 2007, J PSYCHIATR RES, V41, P207, DOI 10.1016/j.jpsychires.2006.10.006
   Ohayon MM, 2006, J PSYCHIATR RES, V40, P30, DOI 10.1016/j.jpsychires.2005.02.003
   Onyike CU, 2003, AM J EPIDEMIOL, V158, P1139, DOI 10.1093/aje/kwg275
   Osborn CY, 2011, ANN BEHAV MED, V41, P300, DOI 10.1007/s12160-010-9241-1
   Ozmen D, 2007, BMC PUBLIC HEALTH, V7, DOI 10.1186/1471-2458-7-80
   Pagoto SL, 2009, J AM DIET ASSOC, V109, P1246, DOI 10.1016/j.jada.2009.04.010
   Palinkas LA, 1996, J PSYCHOSOM RES, V40, P59, DOI 10.1016/0022-3999(95)00542-0
   Pan A, 2012, INT J OBESITY, V36, P595, DOI 10.1038/ijo.2011.111
   Park CM, 2009, INT J SOC PSYCHIATR, V55, P322, DOI 10.1177/0020764008094646
   Park S, 2014, PSYCHOSOMATICS
   Paxton SJ, 2006, J CLIN CHILD ADOLESC, V35, P539, DOI 10.1207/s15374424jccp3504_5
   Payab M, 2012, J DIABETES METABOLIC, P11
   Perquier F, 2014, OBESITY, V22, P1926, DOI 10.1002/oby.20799
   Pickering RP, 2011, J CLIN PSYCHIAT, V72, P1494, DOI 10.4088/JCP.10m06077gry
   Pine DS, 1997, AM J PUBLIC HEALTH, V87, P1303, DOI 10.2105/AJPH.87.8.1303
   Pouwer F, 2010, DIABETIC MED, V27, P217, DOI 10.1111/j.1464-5491.2009.02903.x
   Räikkönen K, 2008, ARCH GEN PSYCHIAT, V65, P290, DOI 10.1001/archgenpsychiatry.2007.40
   Rhew IC, 2008, GEN HOSP PSYCHIAT, V30, P458, DOI 10.1016/j.genhosppsych.2008.06.008
   Richardson LP, 2003, ARCH PEDIAT ADOL MED, V157, P739, DOI 10.1001/archpedi.157.8.739
   Rieck T, 2013, MED SCI SPORT EXER, V45, P1083, DOI 10.1249/MSS.0b013e3182831db1
   Roberts RE, 2000, AM J EPIDEMIOL, V152, P163, DOI 10.1093/aje/152.2.163
   Roberts RE, 2003, INT J OBESITY, V27, P514, DOI 10.1038/sj.ijo.0802204
   Roberts RE, 2013, J PSYCHIATR RES, V47, P1110, DOI 10.1016/j.jpsychires.2013.03.019
   Roos C, 2007, METABOLISM, V56, P825, DOI 10.1016/j.metabol.2007.01.013
   ROSS CE, 1994, J HEALTH SOC BEHAV, V35, P63, DOI 10.2307/2137335
   Rubin RR, 2013, DIABETES CARE, V36, P1088, DOI 10.2337/dc12-1871
   Sachs-Ericsson N, 2007, AM J GERIAT PSYCHIAT, V15, P815, DOI 10.1097/JGP.0b013e3180a725d6
   Savoy SM, 2014, J CARDIOVASC NURS
   Schieman S, 2007, J AGING HEALTH, V19, P286, DOI 10.1177/0898264307299300
   Schmitz N, 2013, J PSYCHOSOM RES, V74, P128, DOI 10.1016/j.jpsychores.2012.09.021
   Schur E, 2013, GEN HOSP PSYCHIAT, V35, P502, DOI 10.1016/j.genhosppsych.2013.04.004
   Scott KA, 2008, J PSYCHOSOM RES, V64, P97, DOI 10.1016/j.jpsychores.2007.09.006
   Sekita A, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-862
   Shinn EH, 2001, AM J HYPERTENS, V14, P660, DOI 10.1016/S0895-7061(01)01304-8
   Simon GE, 2008, GEN HOSP PSYCHIAT, V30, P32, DOI 10.1016/j.genhosppsych.2007.09.001
   Singh G, 2014, INT J OBESITY, V38, P591, DOI 10.1038/ijo.2013.127
   Singh Gopal K, 2013, Depress Res Treat, V2013, P570743, DOI 10.1155/2013/570743
   Sjöberg RL, 2005, PEDIATRICS, V116, pE389, DOI 10.1542/peds.2005-0170
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Smith SS, 2015, J AM COLL HEALTH, V63, P1, DOI 10.1080/07448481.2014.960420
   Smith TJ, 2014, AM J HEALTH BEHAV, V38, P529, DOI 10.5993/AJHB.38.4.6
   Sörberg A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0101213
   Stefanska Ewa, 2014, Rocz Panstw Zakl Hig, V65, P139
   Strine TW, 2008, PSYCHIAT SERV, V59, P1383, DOI 10.1176/appi.ps.59.12.1383
   Subramaniam M, 2013, J PSYCHOSOM RES, V74, P135, DOI 10.1016/j.jpsychores.2012.10.009
   Suhail K, 2002, Eat Weight Disord, V7, P131
   Sulaiman N, 2010, BMC FAM PRACT, V11, DOI 10.1186/1471-2296-11-80
   Sutin AR, 2012, PSYCHOL MED, V42, P2351, DOI 10.1017/S0033291712000566
   Sweileh WM, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-163
   Swencionis C, 2013, HEALTH PSYCHOL, V32, P439, DOI 10.1037/a0029186
   Takayanagi Y, 2014, JAMA PSYCHIAT, V71, P273, DOI 10.1001/jamapsychiatry.2013.3579
   Takeuchi T, 2009, DIABETES-METAB RES, V25, P762, DOI 10.1002/dmrr.1041
   Tanaka H, 2011, BMC PSYCHIATRY, V11, DOI 10.1186/1471-244X-11-20
   Taylor Jacquelyn Y, 2008, Prog Cardiovasc Nurs, V23, P68, DOI 10.1111/j.1751-7117.2008.08128.x
   Taylor KL, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/s12888-014-0327-3
   Thompson C, 2001, BRIT J PSYCHIAT, V179, P450, DOI 10.1192/bjp.179.5.450
   Ting WH, 2012, EUR J PEDIATR, V171, P1247, DOI 10.1007/s00431-012-1753-1
   Tully PJ, 2015, PHYSIOL BEHAV, V139, P328, DOI 10.1016/j.physbeh.2014.11.058
   Ul-Haq Z, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/1471-244X-14-153
   Unayon MM, 2006, J PSYCHIATR RES, V40, P30
   Vanderlip ER, 2014, PSYCHOSOMATICS, V55, P548, DOI 10.1016/j.psym.2014.01.008
   Vanhala M, 2009, ACTA PSYCHIAT SCAND, V119, P137, DOI 10.1111/j.1600-0447.2008.01283.x
   Vargas HO, 2014, LIFE SCI, V102, P65, DOI 10.1016/j.lfs.2014.02.033
   Vilibic M, 2014, CROAT MED J, V55, P520, DOI 10.3325/cmj.2014.55.520
   Viscogliosi G, 2013, INT J GERIATR PSYCH, V28, P242, DOI 10.1002/gps.3817
   Vogelzangs N, 2011, J CLIN PSYCHIAT, V72, P598, DOI 10.4088/JCP.10m06559
   Vogelzangs N, 2010, J CLIN PSYCHIAT, V71, P391, DOI 10.4088/JCP.08m04743blu
   Vogelzangs N, 2009, AM J GERIAT PSYCHIAT, V17, P716, DOI 10.1097/JGP.0b013e3181aad5d7
   Vos T, 2012, LANCET, V380, P2163, DOI 10.1016/S0140-6736(12)61729-2
   Wang H, 2014, J ADOLESCENT HEALTH, V55, P408, DOI 10.1016/j.jadohealth.2014.03.009
   Wild B, 2012, J PSYCHOSOM RES, V72, P376, DOI 10.1016/j.jpsychores.2012.01.019
   Wiltink J, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0105499
   WITTCHEN HU, 1994, J PSYCHIAT RES, V28, P57, DOI 10.1016/0022-3956(94)90036-1
   World Health Organization, 1995, Physical Status: The Use and Interpretation of Anthropometry
   Wyshak G, 2011, HEALTH CARE WOMEN IN, V32, P99, DOI 10.1080/07399332.2010.500899
   Xiang XL, 2015, J PSYCHOSOM RES, V78, P242, DOI 10.1016/j.jpsychores.2014.12.008
   Xie B, 2005, INT J OBESITY, V29, P1137, DOI 10.1038/sj.ijo.0803006
   Yackobovitch-Gavan M, 2014, J HEALTH PSYCHOL, V19, P574, DOI 10.1177/1359105313475901
   Yu Nan-Wen, 2011, Chang Gung Med J, V34, P620
   Yu ZM, 2014, PREV MED, V61, P106, DOI 10.1016/j.ypmed.2013.12.022
   Zahid N, 2008, DIABETES RES CLIN PR, V79, P124, DOI 10.1016/j.diabres.2007.07.006
   Zakeri Marjan, 2012, Acta Med Iran, V50, P177
   Zhong WJ, 2010, DEPRESS ANXIETY, V27, P846, DOI 10.1002/da.20666
NR 206
TC 130
Z9 139
U1 0
U2 47
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1250
EI 1472-1465
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD JUL
PY 2017
VL 211
IS 1
BP 14
EP +
DI 10.1192/bjp.bp.116.186726
PG 61
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EZ3IL
UT WOS:000404604500006
PM 28428339
OA Bronze
DA 2025-06-11
ER

PT J
AU Tang, F
   Wang, GP
   Lian, Y
AF Tang, Fang
   Wang, Gangpu
   Lian, Ying
TI Association between anxiety and metabolic syndrome: A systematic review
   and meta-analysis of epidemiological studies
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE Epidemiological association; Anxiety; Metabolic syndrome
ID PITUITARY-ADRENAL AXIS; HEART-RATE-VARIABILITY; PHYSICAL CONDITIONS;
   DEPRESSION; HEALTH; COMORBIDITY; ANTIDEPRESSANTS; DISABILITY; DISORDERS;
   SYMPTOMS
AB Objective: Epidemiological studies have repeatedly investigated the association between anxiety and metabolic syndrome (MetS). However, the results have been inconsistent. We performed a meta-analysis of observational studies to summarize the evidence regarding the relation of anxiety and MetS risk.
   Methods: We performed a systematic literature search of all studies published in PubMed and EMBASE from its inception to June 2016. Cross-sectional and cohort studies that reported an association between the two conditions in adults were included. Data on prevalence, incidence, unadjusted or adjusted odds ratio (OR), and 95% CI were extracted or provided independently by the authors. Random effects model was used to report the pooled OR. The 12 statistic was used to assess heterogeneity. Egger's test and Begger's test were used to evaluate the publication bias.
   Results: The search yielded 18 cross-sectional studies and two cohort studies. The pooled finding from cross-sectional studies showed that anxiety had a significant positive association with MetS (OR 1.07, 95% CI 1.01-1.12), with moderate heterogeneity (I-2 = 45.7%, P = 0.018). Findings from two cohort studies indicated that the association between anxiety and MetS was insignificant.
   Conclusion: Our results suggest that there is an association between anxiety and MetS. In individuals with MetS anxiety should be detected and managed. Further prospective studies are needed to explore the bidirectional association between anxiety and MetS. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Tang, Fang] Shandong Univ, Qianfoshan Hosp, Hlth Management Ctr, Jinan, Peoples R China.
   [Wang, Gangpu] Fourth Hosp Jinan City, Dept Gen Surg, Jinan, Peoples R China.
   [Lian, Ying] Shandong Univ, Qianfoshan Hosp, Dept Case Adm, Jinan, Peoples R China.
C3 Shandong University; Shandong First Medical University & Shandong
   Academy of Medical Sciences; Shandong First Medical University &
   Shandong Academy of Medical Sciences; Shandong University
RP Lian, Y (corresponding author), Shandong Univ, Qianfoshan Hosp, Dept Case Adm, Jinan, Peoples R China.
EM lianying525@sina.com
FU Shandong provincial Natural Science Foundation [ZR2015HL102]; Department
   of Science and Technology of Shandong Province [2016GSF201075]
FX This work was supported by Shandong provincial Natural Science
   Foundation (ZR2015HL102) and Project of priority research from
   Department of Science and Technology of Shandong Province
   (2016GSF201075).
CR Albert U, 2013, GEN HOSP PSYCHIAT, V35, P154, DOI 10.1016/j.genhosppsych.2012.10.004
   [Anonymous], INT J ENDOCRINOL
   [Anonymous], 2016, J MATERN-FETAL NEO M
   [Anonymous], 2013, PSYCHOL MED, DOI DOI 10.1017/S003329171200147X
   Batelaan NM, 2016, BRIT J PSYCHIAT, V208, P223, DOI 10.1192/bjp.bp.114.156554
   Braig S, 2016, PAEDIATR PERINAT EP, V30, P97, DOI 10.1111/ppe.12255
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   Butnoriene J, 2014, PSYCHONEUROENDOCRINO, V40, P269, DOI 10.1016/j.psyneuen.2013.11.002
   Carroll D, 2009, BIOL PSYCHIAT, V66, P91, DOI 10.1016/j.biopsych.2009.02.020
   Carvalho LA, 2010, EUR NEUROPSYCHOPHARM, V20, P379, DOI 10.1016/j.euroneuro.2010.02.006
   Cohen BE, 2010, PSYCHIAT RES, V175, P133, DOI 10.1016/j.psychres.2009.02.004
   Collings S, 2005, SOC PSYCH PSYCH EPID, V40, P994, DOI 10.1007/s00127-005-0984-0
   Corruble E, 2015, WORLD PSYCHIATRY, V14, P366, DOI 10.1002/wps.20260
   Dortland AKBV, 2010, ACTA PSYCHIAT SCAND, V122, P30, DOI 10.1111/j.1600-0447.2010.01565.x
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   Glaus J, 2013, ACTA PSYCHIAT SCAND, V128, P282, DOI 10.1111/acps.12057
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Hildrum B, 2009, ACTA PSYCHIAT SCAND, V120, P14, DOI 10.1111/j.1600-0447.2008.01315.x
   Hiles SA, 2016, DEPRESS ANXIETY, V33, P754, DOI 10.1002/da.22512
   Hillebrand S, 2013, EUROPACE, V15, P742, DOI 10.1093/europace/eus341
   Hu MX, 2016, PSYCHOSOM MED, V78, P562, DOI 10.1097/PSY.0000000000000313
   Kahl KG, 2015, BRAIN BEHAV, V5, DOI 10.1002/brb3.306
   Karsten J, 2011, J AFFECT DISORDERS, V129, P236, DOI 10.1016/j.jad.2010.09.006
   Karsten J, 2010, J AFFECT DISORDERS, V123, P230, DOI 10.1016/j.jad.2009.10.013
   Kessler RC, 2005, ARCH GEN PSYCHIAT, V62, P593, DOI 10.1001/archpsyc.62.6.593
   Kessler Ronald C, 2009, Psychiatrie (Stuttg), V6, P5
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Liukkonen T, 2011, EUR PSYCHIAT, V26, P363, DOI 10.1016/j.eurpsy.2011.02.001
   Luppino FS, 2011, PSYCHOSOM MED, V73, P257, DOI 10.1097/PSY.0b013e31820a59c0
   Merikangas KR, 2007, ARCH GEN PSYCHIAT, V64, P1180, DOI 10.1001/archpsyc.64.10.1180
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Nishina M, 2011, J ATHEROSCLER THROMB, V18, P396, DOI 10.5551/jat.6692
   Pasquali R, 2006, ANN NY ACAD SCI, V1083, P111, DOI 10.1196/annals.1367.009
   Patel A, 2006, ATHEROSCLEROSIS, V184, P225, DOI 10.1016/j.atherosclerosis.2005.04.012
   Pitsavos C, 2006, ATHEROSCLEROSIS, V185, P320, DOI 10.1016/j.atherosclerosis.2005.06.001
   Powers SI, 2016, PSYCHONEUROENDOCRINO, V69, P172, DOI 10.1016/j.psyneuen.2016.04.007
   Prpic-Krizevac I, 2012, WIEN KLIN WOCHENSCHR, V124, P403, DOI 10.1007/s00508-012-0191-4
   Räikkönen K, 2007, DIABETES CARE, V30, P872, DOI 10.2337/dc06-1857
   Scott KM, 2016, JAMA PSYCHIAT, V73, P150, DOI 10.1001/jamapsychiatry.2015.2688
   Scuteri A, 2015, EUR J PREV CARDIOL, V22, P486, DOI 10.1177/2047487314525529
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Stroup DF, 2000, JAMA-J AM MED ASSOC, V283, P2008, DOI 10.1001/jama.283.15.2008
   Stuckey MI, 2014, DIABETES-METAB RES, V30, P784, DOI 10.1002/dmrr.2555
   Takeuchi T, 2009, DIABETES METAB, V35, P32, DOI 10.1016/j.diabet.2008.06.006
   Takeuchi T, 2009, DIABETES-METAB RES, V25, P762, DOI 10.1002/dmrr.1041
   Tziallas D, 2012, EUR J CARDIOVASC NUR, V11, P297, DOI 10.1016/j.ejcnurse.2011.02.004
   Tziallas Dimitrios, 2011, BMC Res Notes, V4, P105, DOI 10.1186/1756-0500-4-105
   Vogelzangs N, 2007, J GERONTOL A-BIOL, V62, P563, DOI 10.1093/gerona/62.5.563
NR 48
TC 73
Z9 75
U1 0
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAR
PY 2017
VL 77
BP 112
EP 121
DI 10.1016/j.psyneuen.2016.11.025
PG 10
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA EP4UJ
UT WOS:000397375100016
PM 28027497
DA 2025-06-11
ER

PT J
AU Marazziti, D
   Arone, A
   Palermo, S
   Annuzzi, E
   Cappellato, G
   Chiarantini, I
   Del Prete, L
   Dell'Osso, L
AF Marazziti, Donatella
   Arone, Alessandro
   Palermo, Stefania
   Annuzzi, Eric
   Cappellato, Gabriele
   Chiarantini, Ilaria
   Del Prete, Luca
   Dell'Osso, Liliana
TI THE WICKED RELATIONSHIP BETWEEN DEPRESSION AND METABOLIC SYNDROME
SO CLINICAL NEUROPSYCHIATRY
LA English
DT Review
DE major depressive disorder; metabolic syndrome; inflammation; cytokines;
   cardiovascular disease; diet
ID BIPOLAR DISORDER; OXIDATIVE STRESS; DIET QUALITY; SEROTONIN; RISK;
   INFLAMMATION; ASSOCIATION; OBESITY; DYSFUNCTION; MECHANISMS
AB Major depressive disorder (MDD) constitutes a challenge in the field of mental disorders, given its high prevalence in the general population and its impact on the quality of life, while representing a major burden of health worldwide. Currently, much interest in the pathophysiology of MMD is also directed towards disentangling the possible biological mechanisms shared with that medical condition known as metabolic syndrome (MeS) that is frequent in the general population and often comorbid with MDD.Therefore, the aim of this paper was to summarize the evidence on the relationships between depression and MeS, and to comment on the common factors and mediators present in these two conditions. For this reason, some of the main databases of scientific literature were accessed, and all the papers fulfilling the goal of this review were selected. The results demonstrated the existence of common pathways between depression and metabolic syndrome involving several mediators, such as inflammation, the hypothalamus-pituitary-adrenal axis, oxidative stress, platelet functions, coronary heart disease and peripheral hormones, thus requiring strict attention from the scientific community. Indeed, such pathways may be targeted in the near future in order to pave the way to new treatment options for these disorders.
C1 [Marazziti, Donatella; Arone, Alessandro; Palermo, Stefania; Annuzzi, Eric; Cappellato, Gabriele; Chiarantini, Ilaria; Del Prete, Luca; Dell'Osso, Liliana] Univ Pisa, Dept Clin & Expt Med, Sect Psychiat, Pisa, Italy.
   [Marazziti, Donatella] Unicamillus St Camillus Int Univ Med & Hlth Sci, Rome, Italy.
C3 University of Pisa
RP Marazziti, D (corresponding author), Univ Pisa, Dept Clin & Expt Med, Sect Psychiat, Pisa, Italy.; Marazziti, D (corresponding author), Unicamillus St Camillus Int Univ Med & Hlth Sci, Rome, Italy.
EM dmarazzi@psico.med.unipi.it
RI Del Prete, Luca/LSJ-4470-2024
CR Abu Tayab M, 2022, BIOMED PHARMACOTHER, V147, DOI 10.1016/j.biopha.2022.112668
   Al-Khatib Y, 2022, CUREUS J MED SCIENCE, V14, DOI 10.7759/cureus.22153
   Almeida OP, 2019, MATURITAS, V128, P4, DOI 10.1016/j.maturitas.2019.06.009
   Amadio P, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21207560
   Arteaga-Henríquez G, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00458
   Association AP, 2013, Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
   Beyer JL, 2016, PSYCHIAT CLIN N AM, V39, P75, DOI 10.1016/j.psc.2015.10.003
   Bot M, 2020, BIOL PSYCHIAT, V87, P409, DOI 10.1016/j.biopsych.2019.08.016
   Bouillon-Minois JB, 2021, NUTRIENTS, V13, DOI 10.3390/nu13030784
   BROOKS SC, 1978, BIOL PSYCHIAT, V13, P671
   Carbone MG, 2021, LIFE-BASEL, V11, DOI 10.3390/life11080750
   Carney RM, 2017, NAT REV CARDIOL, V14, DOI 10.1038/nrcardio.2016.181
   Catena-Dell'Osso M, 2013, CURR DRUG TARGETS, V14, P571, DOI 10.2174/13894501113149990154
   Catena-Dell'Osso M, 2012, CURR MED CHEM, V19, P428, DOI 10.2174/092986712803414277
   Chantler P, 2018, BRAIN CIRC, V4, P43, DOI 10.4103/bc.bc_6_18
   Chávez-Castillo M, 2020, CURR NEUROPHARMACOL, V18, P1138, DOI 10.2174/1570159X18666200413144401
   Chehab FF, 2000, TRENDS PHARMACOL SCI, V21, P309, DOI 10.1016/S0165-6147(00)01514-5
   Dell'Osso L, 2016, CURR PHARM DESIGN, V22, P949, DOI 10.2174/1381612822666151214104826
   El-Merahbi R, 2015, FEBS LETT, V589, P1728, DOI 10.1016/j.febslet.2015.05.054
   Esteban-Cornejo I, 2021, BRAIN BEHAV IMMUN, V91, P284, DOI 10.1016/j.bbi.2020.10.006
   F Guerreiro Costa Livia N, 2022, Cureus, V14, pe23009, DOI 10.7759/cureus.23009
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Felger JC, 2019, HANDB EXP PHARMACOL, V250, P255, DOI 10.1007/164_2018_166
   Field BCT, 2014, BRIT MED BULL, V109, P73, DOI 10.1093/bmb/ldu001
   Graham N, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-024433
   Guu TW, 2019, PSYCHOTHER PSYCHOSOM, V88, P263, DOI [10.1159/000502652, 10.1159/000504232]
   Harmatz ES, 2017, BIOL PSYCHIAT, V81, P1003, DOI 10.1016/j.biopsych.2016.11.009
   Haroon E, 2012, NEUROPSYCHOPHARMACOL, V37, P137, DOI 10.1038/npp.2011.205
   Höglund E, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00158
   Huang HJ, 2019, NEUROPHARMACOLOGY, V155, P31, DOI 10.1016/j.neuropharm.2019.05.013
   Huang YQ, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.667773
   Jee YH, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-026913
   Jellinger KA, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23010308
   Jiao ZT, 2022, NUTRIENTS, V14, DOI 10.3390/nu14194191
   Kessler RC, 2003, JAMA-J AM MED ASSOC, V289, P3095, DOI 10.1001/jama.289.23.3095
   Kim JY, 2018, J EXERC REHABIL, V14, P592, DOI 10.12965/jer.1836302.151
   Lassale C, 2019, MOL PSYCHIATR, V24, P965, DOI 10.1038/s41380-018-0237-8
   Leff-Gelman P, 2016, NEUROSCI BULL, V32, P398, DOI 10.1007/s12264-016-0048-3
   Li SW, 2020, MOL PSYCHIATR, V25, P1926, DOI 10.1038/s41380-020-0715-7
   Li ZZ, 2021, NEUROSCI BULL, V37, P863, DOI 10.1007/s12264-021-00638-3
   Liu T, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0138904
   MAES M, 1995, PSYCHONEUROENDOCRINO, V20, P111, DOI 10.1016/0306-4530(94)00066-J
   Marazziti D, 2022, CNS SPECTRUMS, V27, P99, DOI 10.1017/S1092852920001820
   Milaneschi Y, 2017, BIOL PSYCHIAT, V81, P807, DOI 10.1016/j.biopsych.2015.10.023
   Miller AH, 2016, NAT REV IMMUNOL, V16, P22, DOI 10.1038/nri.2015.5
   Mirabelli M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041066
   Molendijk M, 2018, J AFFECT DISORDERS, V226, P346, DOI 10.1016/j.jad.2017.09.022
   Moradi F, 2021, EUR J CLIN INVEST, V51, DOI 10.1111/eci.13486
   Mucci F, 2020, LIFE-BASEL, V10, DOI 10.3390/life10060082
   Muti M, 2015, PSYCHIAT RES, V225, P604, DOI 10.1016/j.psychres.2014.11.038
   Ohta Y, 2011, DIABETES, V60, P3208, DOI 10.2337/db10-1192
   Ortiz R, 2015, PROG NEURO-PSYCHOPH, V57, P117, DOI 10.1016/j.pnpbp.2014.10.016
   Pariante Carmine M, 2006, J Psychopharmacol, V20, P79, DOI 10.1177/1359786806066063
   Parletta N, 2019, NUTR NEUROSCI, V22, P474, DOI 10.1080/1028415X.2017.1411320
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   de Melo LGP, 2017, PROG NEURO-PSYCHOPH, V78, P34, DOI 10.1016/j.pnpbp.2017.04.027
   Pierre A, 2019, PSYCHONEUROENDOCRINO, V110, DOI 10.1016/j.psyneuen.2019.104430
   Quirk SE, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-175
   Rajan TM, 2017, J POSTGRAD MED, V63, P182, DOI 10.4103/jpgm.JPGM_712_16
   Rosenblat JD, 2017, BRAIN SCI, V7, DOI 10.3390/brainsci7110144
   Shao MJ, 2020, PSYCHIAT RES, V285, DOI 10.1016/j.psychres.2020.112802
   Sinha R, 2013, BIOL PSYCHIAT, V73, P827, DOI 10.1016/j.biopsych.2013.01.032
   Siwek M, 2013, PHARMACOL REP, V65, P1558, DOI 10.1016/S1734-1140(13)71517-2
   Solleiro-Villavicencio H, 2018, FRONT CELL NEUROSCI, V12, DOI 10.3389/fncel.2018.00114
   STAHL S M., 1985, The platelets: Physiology and pharmacology, P307
   Swarup S., 2022, Metabolic Syndrome
   Tagliarini C, 2022, CNS SPECTRUMS, V27, P157, DOI 10.1017/S1092852920001959
   Tolkien K, 2019, CLIN NUTR, V38, P2045, DOI 10.1016/j.clnu.2018.11.007
   van der Pal KC, 2018, SLEEP MED, V52, P51, DOI 10.1016/j.sleep.2018.07.022
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Villarroel Maria A, 2020, NCHS Data Brief, P1
   Voigt JP, 2015, BEHAV BRAIN RES, V277, P14, DOI 10.1016/j.bbr.2014.08.065
   World Health Organization, 2021, Depression
   Xue YL, 2020, J AFFECT DISORDERS, V260, P11, DOI 10.1016/j.jad.2019.08.081
   Young LM, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092232
   Zaric BL, 2019, CURR MED CHEM, V26, P2948, DOI 10.2174/0929867325666180313105949
   Zhang M, 2021, TRANSL PSYCHIAT, V11, DOI 10.1038/s41398-021-01759-z
NR 77
TC 8
Z9 9
U1 1
U2 1
PU GIOVANNI FIORITI EDITORE
PI ROME
PA VIA ARCHIMEDE 179, ROME, 00197, ITALY
SN 1724-4935
EI 2385-0787
J9 CLIN NEUROPSYCHIATR
JI Clin. Neuropsychiatr.
PD APR
PY 2023
VL 20
IS 2
BP 100
EP 108
DI 10.36131/cnfioritieditore20230202
PG 9
WC Clinical Neurology; Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Neurosciences & Neurology; Psychiatry
GA O3KO1
UT WOS:001042841600002
PM 37234360
DA 2025-06-11
ER

PT J
AU Bouglé, D
   Bouhallab, S
   Bureau, F
   Zunquin, G
AF Bougle, Dominique
   Bouhallab, Said
   Bureau, Francois
   Zunquin, Gautier
TI Effects of trace elements and calcium on diabetes and obesity, and their
   complications: Protective effect of dairy products - A mini-review
SO DAIRY SCIENCE & TECHNOLOGY
LA English
DT Article; Proceedings Paper
CT IDF/INRA 1st International Symposium on Minerals and Dairy Products
CY OCT 01-03, 2008
CL French Res Inst, Saint Malo, FRANCE
SP Dairy Federat
HO French Res Inst
DE calcium; trace element; iron; obesity; diabetes; peroxidation
ID INSULIN-RESISTANCE SYNDROME; IRON-DEFICIENCY; METABOLIC SYNDROME;
   CONSUMPTION; PREVALENCE; CHILDREN; STRESS; MECHANISMS; OVERWEIGHT;
   CHROMIUM
AB Trace elements and minerals influence the pathogenesis of obesity and diabetes and their complications, mainly through their involvement in peroxidation and inflammation. On the other hand, peroxidation and inflammation are liable to alter the metabolism of these nutrients, which should be taken into account when assessing their status. Milk products are capable of preventing iron-induced peroxidation and the metabolic complications of the diseases. Calcium, especially cow milk calcium, seems to be capable of preventing the development of adipocytes and obesity complications (inflammation, hypertension, and insulin resistance), mainly through interactions with vitamin D metabolism. These observations give an opportunity to influence the course of obesity by dietetic advices.
C1 [Bougle, Dominique; Bouhallab, Said; Bureau, Francois; Zunquin, Gautier] CH Bayeux, Ctr Educat Therapeut, Serv Pediat, F-14401 Bayeux, France.
RP Bouglé, D (corresponding author), CH Bayeux, Ctr Educat Therapeut, Serv Pediat, F-14401 Bayeux, France.
EM dbougle@wanadoo.fr
OI Bouhallab, Said/0000-0002-2679-0667
CR Azadbakht L, 2005, AM J CLIN NUTR, V82, P523, DOI 10.1093/ajcn/82.3.523
   Balk EM, 2007, DIABETES CARE, V30, P2154, DOI 10.2337/dc06-0996
   Choi HK, 2005, ARCH INTERN MED, V165, P997, DOI 10.1001/archinte.165.9.997
   Davies KM, 2000, J CLIN ENDOCR METAB, V85, P4635, DOI 10.1210/jc.85.12.4635
   Ferrières J, 2006, CAH NUTR DIET, V41, P33, DOI 10.1016/S0007-9960(06)70605-8
   Forouhi NG, 2007, DIABETOLOGIA, V50, P949, DOI 10.1007/s00125-007-0604-5
   Hummel M, 2007, HORM METAB RES, V39, P743, DOI 10.1055/s-2007-985847
   Lanou AJ, 2008, NUTR REV, V66, P272, DOI 10.1111/j.1753-4887.2008.00032.x
   Lecube A, 2006, OBESITY, V14, P1724, DOI 10.1038/oby.2006.198
   Luan DC, 2008, DIABETES CARE, V31, P285, DOI 10.2337/dc07-0921
   Major GC, 2008, OBES REV, V9, P428, DOI 10.1111/j.1467-789X.2007.00465.x
   Mandato C, 2005, J PEDIATR-US, V147, P62, DOI 10.1016/j.jpeds.2005.02.028
   Marreiro DDN, 2004, BIOL TRACE ELEM RES, V100, P137, DOI 10.1385/BTER:100:2:137
   Moayeri H, 2006, EUR J PEDIATR, V165, P813, DOI 10.1007/s00431-006-0178-0
   Navas-Acien A, 2008, CURR OPIN LIPIDOL, V19, P43, DOI 10.1097/MOL.0b013e3282f2b261
   Ozata M, 2002, CLIN BIOCHEM, V35, P627, DOI 10.1016/S0009-9120(02)00363-6
   Parodi PW, 2007, CURR PHARM DESIGN, V13, P813, DOI 10.2174/138161207780363059
   Pereira MA, 2002, JAMA-J AM MED ASSOC, V287, P2081, DOI 10.1001/jama.287.16.2081
   Pinhas-Hamiel O, 2003, INT J OBESITY, V27, P416, DOI 10.1038/sj.ijo.0802224
   Shi H, 2002, FASEB J, V16, P1808, DOI 10.1096/fj.02-0255fje
   Vari IS, 2007, DIABETES CARE, V30, P1795, DOI 10.2337/dc06-2312
   Vincent HK, 2006, INT J OBESITY, V30, P400, DOI 10.1038/sj.ijo.0803177
   Wintergerst ES, 2007, ANN NUTR METAB, V51, P301, DOI 10.1159/000107673
   Yanoff LB, 2007, INT J OBESITY, V31, P1412, DOI 10.1038/sj.ijo.0803625
   Zemel MB, 2001, J AM COLL NUTR, V20, p428S, DOI 10.1080/07315724.2001.10719180
   Zemel MB, 2002, J AM COLL NUTR, V21, p146S, DOI 10.1080/07315724.2002.10719212
   Zemel MB, 2008, J NUTR, V138, P1047, DOI 10.1093/jn/138.6.1047
   Zunquin G, 2006, FREE RADICAL RES, V40, P535, DOI 10.1080/10715760500451202
NR 28
TC 6
Z9 6
U1 0
U2 9
PU SPRINGER FRANCE
PI PARIS
PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE
SN 1958-5586
EI 1958-5594
J9 DAIRY SCI TECHNOL
JI Dairy Sci. Technol.
PD MAY-AUG
PY 2009
VL 89
IS 3-4
BP 213
EP 218
DI 10.1051/dst/2009010
PG 6
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Food Science & Technology
GA 459GV
UT WOS:000267090500002
DA 2025-06-11
ER

PT J
AU Opsasnick, LA
   Zhao, W
   Ratliff, SM
   Du, JC
   Faul, JD
   Schmitz, LL
   Zhou, X
   Needham, BL
   Smith, JA
AF Opsasnick, Lauren A.
   Zhao, Wei
   Ratliff, Scott M.
   Du, Jiacong
   Faul, Jessica D.
   Schmitz, Lauren L.
   Zhou, Xiang
   Needham, Belinda L.
   Smith, Jennifer A.
TI Epigenome-wide mediation analysis of the relationship between
   psychosocial stress and cardiometabolic risk factors in the Health and
   Retirement Study (HRS)
SO CLINICAL EPIGENETICS
LA English
DT Article
DE Social epigenomics; Psychosocial stress; Cardiometabolic risk factors;
   Cardiovascular disease; Epigenome-wide mediation analysis; DNA
   methylation
ID BODY-MASS INDEX; DNA METHYLATION; R PACKAGE; ASSOCIATION; LOCI; DISEASE;
   GENES; IDENTIFICATION; INFLAMMATION; EPIGENETICS
AB BackgroundExposure to psychosocial stress is linked to a variety of negative health outcomes, including cardiovascular disease and its cardiometabolic risk factors. DNA methylation has been associated with both psychosocial stress and cardiometabolic disease; however, little is known about the mediating role of DNA methylation on the association between stress and cardiometabolic risk. Thus, using the high-dimensional mediation testing method, we conducted an epigenome-wide mediation analysis of the relationship between psychosocial stress and ten cardiometabolic risk factors in a multi-racial/ethnic population of older adults (n = 2668) from the Health and Retirement Study (mean age = 70.4 years).ResultsA total of 50, 46, 7, and 12 CpG sites across the epigenome mediated the total effects of stress on body mass index, waist circumference, high-density lipoprotein cholesterol, and C-reactive protein, respectively. When reducing the dimensionality of the CpG mediators to their top 10 uncorrelated principal components (PC), the cumulative effect of the PCs explained between 35.8 and 46.3% of these associations.ConclusionsA subset of the mediating CpG sites were associated with the expression of genes enriched in pathways related to cytokine binding and receptor activity, as well as neuron development. Findings from this study help to elucidate the underlying mechanisms through which DNA methylation partially mediates the relationship between psychosocial stress and cardiometabolic risk factors.
C1 [Opsasnick, Lauren A.; Zhao, Wei; Ratliff, Scott M.; Needham, Belinda L.; Smith, Jennifer A.] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, 1415 Washington Hts, Ann Arbor, MI 48109 USA.
   [Zhao, Wei; Faul, Jessica D.; Smith, Jennifer A.] Univ Michigan, Inst Social Res, Survey Res Ctr, Ann Arbor, MI USA.
   [Du, Jiacong; Zhou, Xiang] Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI USA.
   [Schmitz, Lauren L.] Univ Wisconsin Madison, Robert M La Follette Sch Publ Affairs, Madison, WI USA.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; University of Michigan System;
   University of Michigan; University of Wisconsin System; University of
   Wisconsin Madison
RP Opsasnick, LA (corresponding author), Univ Michigan, Sch Publ Hlth, Dept Epidemiol, 1415 Washington Hts, Ann Arbor, MI 48109 USA.
EM opsasnic@umich.edu
RI Smith, Albert Vernon/AHC-3838-2022
OI Smith, Jennifer Ann/0000-0002-3575-5468
FU National Human Genome Research Institute
FX Not applicable.
CR Amin MN, 2020, SAGE OPEN MED, V8, DOI 10.1177/2050312120965752
   [Anonymous], 2020, HRS Epigenetic Clocks-Release 1
   Aryee MJ, 2014, BIOINFORMATICS, V30, P1363, DOI 10.1093/bioinformatics/btu049
   Assadi SN, 2017, MEDICINE, V96, DOI [10.1097/MD.0000000000006816, 10.1097/md.0000000000006816]
   Bergen SE, 2012, MOL PSYCHIATR, V17, P880, DOI 10.1038/mp.2012.73
   Bibikova M, 2011, GENOMICS, V98, P288, DOI 10.1016/j.ygeno.2011.07.007
   Bower JE, 2014, CLIN PSYCHOL SCI, V2, P108, DOI 10.1177/2167702613496243
   Buscemi V, 2017, SYST REV-LONDON, V6, DOI 10.1186/s13643-017-0618-0
   Cardenas A, 2019, CLIN EPIGENETICS, V11, DOI 10.1186/s13148-019-0653-x
   Chatterjee A, 2012, Canadian Family Physician Medecine de famille canadien, V58, P196
   Cheng C, 2021, BMC MED RES METHODOL, V21, DOI 10.1186/s12874-021-01425-4
   Chinedu SN, 2013, J PUBLIC HEALTH RES, V2, P93, DOI 10.4081/jphr.2013.e16
   Cozlea D L, 2013, Curr Health Sci J, V39, P225
   Crimmins E, 2013, DOCUMENTATION BIOMAR, DOI DOI 10.7826/ISR-UM.06.585031.001.05.0014.2008
   Crimmins E., 2016, Venous blood collection and assay protocol in the 2016 health and retirement study. 2016 Venous Blood Study (VBS)
   Crosswell AD, 2020, J GERONTOL B-PSYCHOL, V75, P970, DOI 10.1093/geronb/gby106
   Cuevas AG, 2021, J GERONTOL B-PSYCHOL, V76, P1580, DOI 10.1093/geronb/gbaa142
   Cuevas AG, 2019, ANN BEHAV MED, V53, P964, DOI 10.1093/abm/kaz008
   Dai JY, 2022, J AM STAT ASSOC, V117, P198, DOI 10.1080/01621459.2020.1765785
   Dar Tawseef, 2019, Curr Treat Options Cardiovasc Med, V21, P23, DOI 10.1007/s11936-019-0724-5
   Di Lena P, 2020, BMC BIOINFORMATICS, V21, DOI 10.1186/s12859-020-03592-5
   Du JC, 2023, GENET EPIDEMIOL, V47, P167, DOI 10.1002/gepi.22510
   Geurts YM, 2018, INT J OBESITY, V42, P887, DOI 10.1038/ijo.2017.269
   Giurgescu C, 2019, J URBAN HEALTH, V96, P23, DOI 10.1007/s11524-018-00341-1
   Glaser R, 2005, NAT REV IMMUNOL, V5, P243, DOI 10.1038/nri1571
   Hajar Rachel, 2016, Heart Views, V17, P78, DOI 10.4103/1995-705X.185130
   Hardy LM, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18091892
   Health and Retirement Study, 2021, Quality control report for genotypic data
   Heraclides A, 2009, DIABETES CARE, V32, P2230, DOI 10.2337/dc09-0132
   Hillary RF, 2023, PLOS MED, V20, DOI 10.1371/journal.pmed.1004247
   Houseman EA, 2012, BMC BIOINFORMATICS, V13, DOI 10.1186/1471-2105-13-86
   Houtepen LC, 2018, TRANSL PSYCHIAT, V8, DOI 10.1038/s41398-018-0307-3
   Isasi CR, 2015, ANN EPIDEMIOL, V25, P84, DOI 10.1016/j.annepidem.2014.11.002
   Jin DY, 1999, GENOMICS, V55, P363, DOI 10.1006/geno.1998.5654
   Johnson TV, 2013, MOL DIAGN THER, V17, P147, DOI 10.1007/s40291-013-0026-7
   Juster FT, 1995, J HUM RESOUR, V30, pS7, DOI 10.2307/146277
   Kalinowski J, 2022, EPIGENETICS INSIGHTS, V15, DOI 10.1177/25168657221126314
   Kelley C, 2022, J PERS MED, V12, DOI 10.3390/jpm12111829
   Kennel PJ, 2019, CIRC-HEART FAIL, V12, DOI 10.1161/CIRCHEARTFAILURE.119.006336
   Kent WJ, 2002, GENOME RES, V12, P996, DOI 10.1101/gr.229102
   Keshawarz A, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-39936-3
   Kim YK, 2003, ACTA NEUROPSYCHIATR, V15, P148, DOI 10.1034/j.1601-5215.2003.00026.x
   Lacaze P, 2021, OPEN HEART, V8, DOI 10.1136/openhrt-2021-001710
   Lagou V, 2023, NAT GENET, V55, P1448, DOI 10.1038/s41588-023-01462-3
   Lam LL, 2012, P NATL ACAD SCI USA, V109, P17253, DOI 10.1073/pnas.1121249109
   LeBlanc M, 2016, CIRC RES, V118, P83, DOI 10.1161/CIRCRESAHA.115.306629
   Levey DF, 2020, AM J PSYCHIAT, V177, P223, DOI 10.1176/appi.ajp.2019.19030256
   Ligthart S, 2016, GENOME BIOL, V17, DOI 10.1186/s13059-016-1119-5
   Liu J, 2019, NAT COMMUN, V10, DOI [10.1038/s41467-019-10487-4, 10.1038/s41467-019-10963-x]
   Liu MY, 2017, NEUROL RES, V39, P573, DOI 10.1080/01616412.2017.1317904
   Liu YD, 2015, SCI REP-UK, V5, DOI 10.1038/srep16954
   Lumertz FS, 2022, NEUROSCI BIOBEHAV R, V139, DOI 10.1016/j.neubiorev.2022.104746
   Luo MN, 2021, AM J MED GENET B, V186, P228, DOI 10.1002/ajmg.b.32862
   Matsuo M, 2022, J PHARMACOL SCI, V148, P197, DOI 10.1016/j.jphs.2021.11.005
   Moog NK, 2021, PSYCHONEUROENDOCRINO, V125, DOI 10.1016/j.psyneuen.2020.105102
   Nater UM, 2013, CURR OPIN PSYCHIATR, V26, P440, DOI 10.1097/YCO.0b013e328363b4ed
   Nikpay M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13061984
   Olvera Lopez E, 2024, StatPearls Internet
   Opsasnick LA, 2024, EPIGENETICS-US, V19, DOI 10.1080/15592294.2024.2323907
   Palma-Gudiel H, 2015, NEUROSCI BIOBEHAV R, V55, P520, DOI 10.1016/j.neubiorev.2015.05.016
   Paz MA, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000004071
   Peloso GM, 2019, CIRC-GENOM PRECIS ME, V12, DOI 10.1161/CIRCGEN.118.002376
   Peloso GM, 2014, AM J HUM GENET, V94, P223, DOI 10.1016/j.ajhg.2014.01.009
   Perera C, 2022, BMC BIOINFORMATICS, V23, DOI 10.1186/s12859-022-04748-1
   Phipson B, 2016, BIOINFORMATICS, V32, P286, DOI 10.1093/bioinformatics/btv560
   Pidsley R, 2016, GENOME BIOL, V17, DOI 10.1186/s13059-016-1066-1
   Richard MA, 2017, AM J HUM GENET, V101, P888, DOI 10.1016/j.ajhg.2017.09.028
   Richardson TG, 2017, AM J HUM GENET, V101, P590, DOI 10.1016/j.ajhg.2017.09.003
   Ripke S, 2013, NAT GENET, V45, P1150, DOI 10.1038/ng.2742
   Ruffo P, 2023, NEURAL REGEN RES, V18, P1243, DOI 10.4103/1673-5374.358615
   Ruparelia N, 2017, NAT REV CARDIOL, V14, DOI [10.1038/nrcardio.2016.185, 10.1038/nrcardio.2017.33]
   Santosa A, 2021, JAMA NETW OPEN, V4, DOI 10.1001/jamanetworkopen.2021.38920
   Sayols-Baixeras S, 2016, HUM MOL GENET, V25, P4556, DOI 10.1093/hmg/ddw285
   Sharma D, 2021, ELIFE, V10, DOI [10.7554/eLife.71595, 10.7554/eLife.71595.sa1, 10.7554/eLife.71595.sa2]
   Sharp GC, 2017, HUM MOL GENET, V26, P4067, DOI 10.1093/hmg/ddx290
   Smith J., 2017, Psychosocial and Lifestyle Questionnaire 2006-2016: Documentation Report Core Section LB
   Smith JA, 2017, EPIGENETICS-US, V12, P662, DOI 10.1080/15592294.2017.1341026
   Sokolov AV, 2023, CLIN EPIGENETICS, V15, DOI 10.1186/s13148-022-01394-5
   Solomon O, 2022, MUTAT RES-REV MUTAT, V789, DOI 10.1016/j.mrrev.2022.108415
   Somineni HK, 2019, GASTROENTEROLOGY, V156, P2254, DOI 10.1053/j.gastro.2019.01.270
   Sonnega A, 2014, INT J EPIDEMIOL, V43, P576, DOI 10.1093/ije/dyu067
   Sorriento D, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20163879
   Sousa N, 2012, TRENDS NEUROSCI, V35, P742, DOI 10.1016/j.tins.2012.08.006
   Stadler JT, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9030242
   Sternthal MJ, 2011, DU BOIS REV, V8, P95, DOI 10.1017/S1742058X11000087
   Sun DJY, 2019, CIRC RES, V125, P824, DOI 10.1161/CIRCRESAHA.119.315397
   Tang XY, 2021, SCI REP-UK, V11, DOI [10.1038/s41598-021-90638-0, 10.1038/s41598-021-01569-9]
   Tian R, 2014, SCI WORLD J, DOI 10.1155/2014/780616
   Tingley D, 2014, J STAT SOFTW, V59
   Tsao CW, 2023, CIRCULATION, V147, pE93, DOI 10.1161/CIR.0000000000001123
   U.S. National Library of Medicine, LOC100130298 hCG1816373-like Homo Sapiens (human)-gene-NCBI
   van der Harst P, 2018, CIRC RES, V122, P433, DOI [10.1161/CIRCRESAHA.117.312086, 10.1161/circresaha.117.312086]
   Visser M, 1999, JAMA-J AM MED ASSOC, V282, P2131, DOI 10.1001/jama.282.22.2131
   Vyas S, 2016, NEURAL PLAST, V2016, DOI 10.1155/2016/6391686
   Wahl S, 2017, NATURE, V541, P81, DOI 10.1038/nature20784
   Wang YZ, 2022, FRONT CARDIOVASC MED, V9, DOI 10.3389/fcvm.2022.848768
   Westerman K, 2019, CLIN EPIGENETICS, V11, DOI 10.1186/s13148-019-0705-2
   Willerson JT, 2004, CIRCULATION, V109, P2, DOI 10.1161/01.CIR.0000129535.04194.38
   Williamson A, 2023, NAT GENET, V55, P973, DOI 10.1038/s41588-023-01408-9
   Wu HZ, 2020, CIRC RES, V126, P1549, DOI 10.1161/CIRCRESAHA.119.315896
   Wu ZY, 2022, CLIN EPIGENETICS, V14, DOI 10.1186/s13148-022-01356-x
   Yang XJ, 2021, J HUM HYPERTENS, V35, P1149, DOI 10.1038/s41371-021-00546-z
   Yu GC, 2012, OMICS, V16, P284, DOI 10.1089/omi.2011.0118
   Zannas AS, 2019, DIALOGUES CLIN NEURO, V21, P389, DOI 10.31887/DCNS.2019.21.4/azannas
   Zeng P, 2021, COMPUT STRUCT BIOTEC, V19, P3209, DOI 10.1016/j.csbj.2021.05.042
   Zhang HX, 2021, BIOINFORMATICS, V37, P3815, DOI 10.1093/bioinformatics/btab564
NR 106
TC 2
Z9 2
U1 3
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1868-7075
EI 1868-7083
J9 CLIN EPIGENETICS
JI Clin. Epigenetics
PD DEC 18
PY 2024
VL 16
IS 1
AR 180
DI 10.1186/s13148-024-01799-4
PG 16
WC Oncology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Genetics & Heredity
GA P9D9S
UT WOS:001380836200001
PM 39695878
OA gold
DA 2025-06-11
ER

PT J
AU Novak, JR
   Robinson, LP
   Korn, LE
AF Novak, Josh R.
   Robinson, Lindsey P.
   Korn, Leslie E.
TI What MFTs should know about nutrition, psychosocial health, and
   collaborative care with nutrition professionals
SO JOURNAL OF MARITAL AND FAMILY THERAPY
LA English
DT Article
DE assessment; collaborative care; diet; mental health; nutrition;
   treatment
ID SOCIAL SUPPORT; EMOTION SUPPRESSION; METABOLIC SYNDROME;
   SELF-MANAGEMENT; WEIGHT-LOSS; DEPRESSION; BEHAVIOR; MODEL; DIET;
   ASSOCIATION
AB Despite sufficient evidence on the role of nutrition in psychosocial health, Marriage and Family Therapists lack the knowledge for sufficient assessment and referrals in treatment. The purpose of this article is to orient MFTs to human metabolism and the effects of various nutrients, or lack thereof, on the psychosocial health in their clients. The roles of several micronutrients and macronutrients will be described as well as the effects of eating patterns and overall metabolic health on mental health. Finally, implications for MFTs as sole practitioners, domains for assessment and psychoeducation, and recommendations for collaborating with nutrition professionals will be discussed.
C1 [Novak, Josh R.; Robinson, Lindsey P.; Korn, Leslie E.] Auburn Univ, Dept Human Dev & Family Sci, Auburn, AL 36849 USA.
C3 Auburn University System; Auburn University
RP Novak, JR (corresponding author), Glanton House,312 Quad Dr, Auburn, AL 36832 USA.
EM jrn0031@auburn.edu
OI Novak, Joshua/0000-0002-9714-1226
CR Academies N., 2005, DIET REF INT EN CARB, V5
   American Nutrition Association, 2021, BEC CNS
   Anderson BarbaraJ., 1984, Family Systems Medicine, V2, P17
   [Anonymous], 2004, NUTR REV, V62, P73, DOI 10.1111/j.1753-4887.2004.tb00028.x
   Arden J.B., 2015, Brain2Brain: Enacting client change through the persuasive power of neuroscience
   Astrup A, 2019, INT J OBESITY, V43, P219, DOI 10.1038/s41366-018-0143-9
   Aucoin Monique, 2016, Case Rep Psychiatry, V2016, P7165425, DOI 10.1155/2016/7165425
   Ball K, 2006, INT J OBESITY, V30, P1240, DOI 10.1038/sj.ijo.0803267
   Benton D, 2002, NEUROSCI BIOBEHAV R, V26, P293, DOI 10.1016/S0149-7634(02)00004-0
   Black MM, 2003, J NUTR, V133, p3927S, DOI 10.1093/jn/133.11.3927S
   Bouayed J, 2010, OXID MED CELL LONGEV, V3, P228, DOI 10.4161/oxim.3.4.12858
   Bozzatello P, 2016, J CLIN MED, V5, DOI 10.3390/jcm5080067
   Brewer-Lowry AN, 2010, GERONTOLOGIST, V50, P657, DOI 10.1093/geront/gnq001
   Butler EA, 2010, J SOC CLIN PSYCHOL, V29, P599, DOI 10.1521/jscp.2010.29.6.599
   Carter MJ, 2014, THER RECREAT J, V48, P275
   Chesla CA, 2005, QUAL HEALTH RES, V15, P240, DOI 10.1177/1049732304272050
   Christakos S, 2019, METABOLISM, V98, P112, DOI 10.1016/j.metabol.2019.06.010
   D'Arrigo Terri, 2007, Diabetes Forecast, V60, P23
   Davillas A, 2017, J HEALTH ECON, V56, P87, DOI 10.1016/j.jhealeco.2017.09.010
   DeJesse LD, 2013, EAT DISORD, V21, P185, DOI 10.1080/10640266.2013.779173
   Eby GA, 2006, MED HYPOTHESES, V67, P362, DOI 10.1016/j.mehy.2006.01.047
   Edwards TM, 2002, AM J FAM THER, V30, P243, DOI 10.1080/019261802753577566
   Eliot KA, 2015, J ACAD NUTR DIET, V115, P1578, DOI 10.1016/j.jand.2015.03.025
   ENGEL GL, 1981, J MED PHILOS, V6, P101, DOI 10.1093/jmp/6.2.101
   ENGEL GL, 1977, SCIENCE, V196, P129, DOI 10.1126/science.847460
   Esper DH, 2015, NUTR CLIN PRACT, V30, P194, DOI 10.1177/0884533615573054
   Ferrer RA, 2017, EMOTION, V17, P1052, DOI 10.1037/emo0000295
   Frazier, 2012, KNOWLEDGE ATTITUDES
   Gallant MP, 2003, HEALTH EDUC BEHAV, V30, P170, DOI 10.1177/1090198102251030
   Geoffroy, 2017, SCI PRACTICE LITHIUM, DOI [10.1007/978-3-319-45923-3_6, DOI 10.1007/978-3-319-45923-3_6]
   Gershon MD, 2007, GASTROENTEROLOGY, V132, P397, DOI 10.1053/j.gastro.2006.11.002
   Glenn JM, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061315
   Gómez-Pinilla F, 2008, NAT REV NEUROSCI, V9, P568, DOI 10.1038/nrn2421
   Gonder-Frederick, 1997, Semin Clin Neuropsychiatry, V2, P57
   Gonzalez N. J., 2017, NUTR AUTONOMIC NERVO
   Goodman CR, 2002, AGING MENT HEALTH, V6, P266, DOI 10.1080/13607860220142431
   Goodpaster BH, 2017, CELL METAB, V25, P1027, DOI 10.1016/j.cmet.2017.04.015
   Gorin AA, 2018, OBESITY, V26, P499, DOI 10.1002/oby.22098
   Hanson B.G., 1995, GEN SYSTEMS THEORY B
   Harbottle L, 2008, J MENT HEALTH, V17, P576, DOI 10.1080/09638230701677746
   Harp A.G., 2013, THESIS PRO QUEST DIS
   Hindle L, 2011, J HUM NUTR DIET, V24, P342, DOI 10.1111/j.1365-277X.2011.01156.x
   Homish GG, 2008, AM J HEALTH BEHAV, V32, P754, DOI 10.5555/ajhb.2008.32.6.754
   Jacka FN, 2017, BMC MED, V15, DOI 10.1186/s12916-017-0791-y
   Jacka FN, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0087657
   Johnson, 2010, INQUIRIES J STUDENT, V2
   Kar, 2017, TRIANNUAL J, P69, DOI [10.21088/jpn.2277.9035.6217.6, DOI 10.21088/JPN.2277.9035.6217.6]
   Kiernan M, 2012, OBESITY, V20, P756, DOI 10.1038/oby.2011.293
   Klein JE, 1937, ARCH DERMATOL SYPH, V36, P287, DOI 10.1001/archderm.1937.01480020043005
   Konttinen H, 2010, APPETITE, V54, P473, DOI 10.1016/j.appet.2010.01.014
   Korn, 2017, GOOD MOOD KITCHEN SI
   Korn L.E., 2016, Nutrition essentials for mental health: a complete guide to the food-mood connection
   Kris-Etherton PM, 2021, NUTR REV, V79, P247, DOI 10.1093/nutrit/nuaa025
   Lakhan SE, 2008, NUTR J, V7, DOI 10.1186/1475-2891-7-2
   Lambrinakou S, 2017, ADV EXP MED BIOL, V987, P23, DOI 10.1007/978-3-319-57379-3_3
   Makki K, 2018, CELL HOST MICROBE, V23, P705, DOI 10.1016/j.chom.2018.05.012
   Mariotti F, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112661
   Martin CR, 2018, CELL MOL GASTROENTER, V6, P133, DOI 10.1016/j.jcmgh.2018.04.003
   Mattson MP, 2014, P NATL ACAD SCI USA, V111, P16647, DOI 10.1073/pnas.1413965111
   McDaniel S.H., 1995, Family Systems Medicine, V13, P283
   Meltzer AL, 2012, J FAM PSYCHOL, V26, P678, DOI 10.1037/a0029364
   Meyler D, 2007, SOC SCI MED, V64, P2297, DOI 10.1016/j.socscimed.2007.02.007
   Nousen EK, 2013, NEUROENDOCRINOLOGY, V98, P254, DOI 10.1159/000355632
   Novak JR, 2021, PSYCHOL HEALTH, V36, P1147, DOI 10.1080/08870446.2020.1836179
   Opie RS, 2017, NUTR NEUROSCI, V20, P161, DOI 10.1179/1476830515Y.0000000043
   Opie RS, 2015, PUBLIC HEALTH NUTR, V18, P2074, DOI 10.1017/S1368980014002614
   Paans NPG, 2018, J PSYCHIATR RES, V97, P38, DOI 10.1016/j.jpsychires.2017.11.003
   Palkowska-Gozdzik E, 2018, NUTRIENTS, V10, DOI 10.3390/nu10010005
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Peet M, 2005, DRUGS, V65, P1051, DOI 10.2165/00003495-200565080-00002
   Penckofer Sue, 2010, Issues Ment Health Nurs, V31, P385, DOI 10.3109/01612840903437657
   Poorrezaeian M, 2015, PSYCHIAT RES, V230, P622, DOI 10.1016/j.psychres.2015.10.016
   Pratt KJ, 2014, AM J FAM THER, V42, P364, DOI 10.1080/01926187.2013.878170
   Procyk, 2018, NUTR TREATMENTS IMPR
   Riebl SK, 2013, ACSMS HEALTH FIT J, V17, P21, DOI 10.1249/FIT.0b013e3182a9570f
   Robinson SL, 2020, J NUTR, V150, P140, DOI 10.1093/jn/nxz185
   Robinson W.D., 2016, SAGE ENCY MARRIAGE F
   Roca M, 2016, BMC PSYCHIATRY, V16, DOI 10.1186/s12888-016-0900-z
   Ross BM, 2007, LIPIDS HEALTH DIS, V6, DOI 10.1186/1476-511X-6-21
   Rydén PJ, 2011, SCAND J CARING SCI, V25, P583, DOI 10.1111/j.1471-6712.2010.00867.x
   Ryu JY, 2018, P NATL ACAD SCI USA, V115, pE4304, DOI 10.1073/pnas.1803294115
   Scott KA, 2012, CURR OBES REP, V1, DOI 10.1007/s13679-011-0006-3
   Seaburn D.B., 1996, MODELS COLLABORATION
   Shilstone, 2001, LOSE YOUR LOVE HANDL
   Snoek HM, 2007, APPETITE, V49, P223, DOI 10.1016/j.appet.2007.02.004
   Spoor STP, 2007, APPETITE, V48, P368, DOI 10.1016/j.appet.2006.10.005
   Stanforth D, 2009, ACSMS HEALTH FIT J, V13, P14, DOI 10.1249/FIT.0b013e3181a1b79a
   Stapleton P., 2014, Current Research in Psychology, V5, P77, DOI DOI 10.3844/CRPSP.2014.77.88
   Story M, 2008, ANNU REV PUBL HEALTH, V29, P253, DOI 10.1146/annurev.publhealth.29.020907.090926
   Suldo S.M., 2000, J COLL STUD PSYCH, V15, P59, DOI 10.1300/J035v15n01_07
   Swan WI, 2017, J ACAD NUTR DIET, V117, P2003, DOI 10.1016/j.jand.2017.07.015
   Taylor AM, 2020, NUTR NEUROSCI, V23, P237, DOI 10.1080/1028415X.2018.1493808
   The Academy of Nutrition and Dietetics, 2021, RDN NDTR OV
   The Academy of Nutrition and Dietetics, 2021, EV REG DIET IS NUTR
   The Academy of Nutrition and Dietetics, 2021, WHAT IS REG DIET NUT
   v Bertalanffy L., 1952, PROBLEMS LIFE EVALUA
   Van Strien T, 2005, APPETITE, V45, P205, DOI 10.1016/j.appet.2005.08.004
   Walker WH II, 2020, TRANSL PSYCHIAT, V10, DOI 10.1038/s41398-020-0694-0
   Weil A., 2000, EATING WELL OPTIMUM
   Wen LK, 2004, DIABETES EDUCATOR, V30, P980, DOI 10.1177/014572170403000619
   Wing RR, 2005, AM J CLIN NUTR, V82, p222S, DOI 10.1093/ajcn/82.1.222S
   Wittbrodt MT, 2018, PHYSIOL REP, V6, DOI 10.14814/phy2.13805
   Wong M, 2005, CAN J DIET PRACT RES, V66, P215, DOI 10.3148/66.4.2005.215
NR 103
TC 1
Z9 2
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0194-472X
EI 1752-0606
J9 J MARITAL FAM THER
JI J. Marital Fam. Ther.
PD APR
PY 2022
VL 48
IS 2
BP 502
EP 522
DI 10.1111/jmft.12540
EA JUL 2021
PG 21
WC Psychology, Clinical; Family Studies
WE Social Science Citation Index (SSCI)
SC Psychology; Family Studies
GA 0N3HM
UT WOS:000673659600001
PM 34264531
DA 2025-06-11
ER

PT J
AU Konstantinidou, SK
   Argyrakopoulou, G
   Tentolouris, N
   Karalis, V
   Kokkinos, A
AF Konstantinidou, Sofia K.
   Argyrakopoulou, Georgia
   Tentolouris, Nicholas
   Karalis, Vangelis
   Kokkinos, Alexander
TI Interplay between baroreflex sensitivity, obesity and related
   cardiometabolic risk factors (Review)
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Review
DE BRS; obesity; autonomic disorders; blood pressure regulation; metabolic
   syndrome
ID SYMPATHETIC-NERVE ACTIVITY; TYPE-2 DIABETES-MELLITUS; BLOOD-PRESSURE;
   SYMPATHOVAGAL IMBALANCE; AUTONOMIC REGULATION; RESISTANCE EXERCISE;
   METABOLIC SYNDROME; BARIATRIC SURGERY; RECEPTOR GENE; WEIGHT-LOSS
AB The baroreflex represents a rapid negative feedback system implicated in blood pressure regulation, which aims to prevent blood pressure variations by regulating peripheral vascular tone and cardiac output. The aim of the present review was to highlight the association between baroreflex sensitivity (BRS) and obesity, including factors associated with obesity, such as metabolic syndrome, hypertension, cardiovascular disease and diabetes. For the present review, a literature search was conducted using the PubMed database until August 21, 2021. The searched terms included 'baroreflex', and other terms such as 'sensitivity', 'obesity', 'metabolic syndrome', 'hypertension', 'diabetes', 'gender', 'aging', 'children', 'adolescents', 'physical activity', 'bariatric surgery', 'autonomous nervous system' and 'cardiometabolic risk factors'. Obesity and its related metabolic disorders can influence baroreflex functionality and decrease BRS, mostly by potentiating sympathetic nervous system activity. Obesity induces inflammation, which can increase sympathetic system activity and lead to a higher incidence of cardiovascular events. Obesity also represents an important risk factor for hypertension through numerous mechanisms; in this setting, dysfunctional baroreceptors are not able to protect against constantly elevated blood pressure. Furthermore, diabetes mellitus and oxidative stress result in deterioration of BRS, whereas aging is also generally related to reduced cardiovagal BRS. Differences in BRS have also been observed between men and women, and overall cardiovagal BRS in healthy women is less intense compared with that in men. BRS appears lower in children with obesity compared with that in children of a healthy weight. Notably, physical exercise can increase BRS in both hypertensive and normotensive subjects, and BRS can also be significantly improved following bariatric surgery and weight loss. In conclusion, obesity and its related metabolic disorders may influence baroreflex functionality and decrease BRS, and baroreceptors cannot protect against the constantly elevated blood pressure in obesity. However, following bariatric surgery and weight loss, BRS can be significantly improved. The present review summarizes the role of obesity and related metabolic risk factors in BRS, providing details on possible mechanisms and shedding light on their interplay leading to autonomic neuropathy.
C1 [Konstantinidou, Sofia K.; Tentolouris, Nicholas; Kokkinos, Alexander] Natl & Kapodistrian Univ Athens, Sch Med, Laiko Gen Hosp, Dept Propaedeut Internal Med 1, 17 Aghiou Thoma, Athens 11527, Greece.
   [Konstantinidou, Sofia K.; Argyrakopoulou, Georgia] Athens Med Ctr, Diabet & Obes Unit, Athens 15125, Greece.
   [Karalis, Vangelis] Natl & Kapodistrian Univ Athens, Sch Hlth Sci, Dept Pharm, Athens 15784, Greece.
C3 National & Kapodistrian University of Athens; Laiko General Hospital;
   Athens Medical School; National & Kapodistrian University of Athens
RP Konstantinidou, SK (corresponding author), Natl & Kapodistrian Univ Athens, Sch Med, Laiko Gen Hosp, Dept Propaedeut Internal Med 1, 17 Aghiou Thoma, Athens 11527, Greece.
EM sofiakon@med.uoa.gr
RI Karalis, Vangelis/L-9642-2019; Argyrakopoulou, Georgia/AAT-6172-2021;
   Konstantinidou, Sofia/JVM-9062-2024; Kokkinos, A/K-6345-2019
OI Argyrakopoulou, Georgia/0000-0001-5502-565X
FU Onassis Foundation [G ZO 011-1/2018-2019]
FX The present study was supported by the Onassis Foundation (grant no. G
   ZO 011-1/2018-2019).
CR Abboud FM, 2017, ADV PHYSIOL EDUC, V41, P578, DOI 10.1152/advan.00061.2017
   Al-Khateeb AA, 2017, CLIN AUTON RES, V27, P17, DOI 10.1007/s10286-016-0389-z
   Alnima T, 2014, EXPERT REV CARDIOVAS, V12, P955, DOI 10.1586/14779072.2014.931226
   Baker SE, 2016, AM J PHYSIOL-REG I, V311, pR1271, DOI 10.1152/ajpregu.00288.2016
   Bonyhay I, 1996, AM J PHYSIOL-HEART C, V271, pH1139, DOI 10.1152/ajpheart.1996.271.3.H1139
   Brooks VL, 2015, AUTON NEUROSCI-BASIC, V187, P18, DOI 10.1016/j.autneu.2014.11.006
   Cassaglia PA, 2011, J PHYSIOL-LONDON, V589, P1643, DOI 10.1113/jphysiol.2011.205575
   Chen W, 2015, HERZ, V40, P190, DOI 10.1007/s00059-014-4072-7
   Ciriello J, 2013, PEPTIDES, V44, P1, DOI 10.1016/j.peptides.2013.03.021
   da Silva RP, 2013, OBES SURG, V23, P1835, DOI 10.1007/s11695-013-0988-x
   Demidowich AP, 2020, INT J OBESITY, V44, P1793, DOI 10.1038/s41366-020-0598-3
   Dieli-Conwright CM, 2018, J CLIN ONCOL, V36, P875, DOI 10.1200/JCO.2017.75.7526
   Dombrowski M, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01829
   Drew RC, 2017, AM J PHYSIOL-REG I, V313, pR654, DOI 10.1152/ajpregu.00242.2017
   Engin A, 2017, ADV EXP MED BIOL, V960, P1, DOI 10.1007/978-3-319-48382-5_1
   Rubio-Ruiz ME, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20030647
   Fantin F, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071667
   Fu Q, 2019, J PHYSIOL SCI, V69, P851, DOI 10.1007/s12576-019-00727-z
   Fukuma N, 2012, CLIN PHYSIOL FUNCT I, V32, P305, DOI 10.1111/j.1475-097X.2012.01127.x
   Funakoshi K, 2014, J CARD FAIL, V20, P53, DOI 10.1016/j.cardfail.2013.11.007
   Gerritsen J, 2001, DIABETES CARE, V24, P1793, DOI 10.2337/diacare.24.10.1793
   Gollasch M, 2002, J HYPERTENS, V20, P927, DOI 10.1097/00004872-200205000-00028
   Grassi G, 2005, HYPERTENSION, V46, P321, DOI 10.1161/01.HYP.0000174243.39897.6c
   Grassi G, 2005, DIABETOLOGIA, V48, P1359, DOI 10.1007/s00125-005-1798-z
   Guarino D, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00665
   Guyenet PG, 2020, HYPERTENSION, V76, P300, DOI 10.1161/HYPERTENSIONAHA.120.14521
   Hamlin MJ, 2012, J HUM KINET, V31, P97, DOI 10.2478/v10078-012-0010-z
   Hendricks AS, 2019, AM J PHYSIOL-HEART C, V316, pH1458, DOI 10.1152/ajpheart.00497.2018
   Honzíková N, 2006, KLIN PADIATR, V218, P237, DOI 10.1055/s-2005-836596
   Honzíková N, 2016, PHYSIOL RES, V65, P879, DOI 10.33549/physiolres.933271
   Iliescu R, 2013, AM J PHYSIOL-HEART C, V305, P1080, DOI 10.1152/ajpheart.00464.2013
   Indumathy J, 2015, METABOLISM, V64, P1704, DOI 10.1016/j.metabol.2015.09.009
   Jais A, 2017, J CLIN INVEST, V127, P24, DOI 10.1172/JCI88878
   Javorka M., 2013, CAN J DIABETES, V37
   Javorka M, 2011, MED BIOL ENG COMPUT, V49, P279, DOI 10.1007/s11517-010-0707-x
   Jíra M, 2010, PHYSIOL RES, V59, P517, DOI 10.33549/physiolres.931747
   Khan SA, 2017, ACTA PHYSIOL, V221, P250, DOI 10.1111/apha.12891
   Kingsley JD, 2019, J SPORT MED PHYS FIT, V59, P1036, DOI 10.23736/S0022-4707.18.08864-3
   Kishi T, 2018, HYPERTENS RES, V41, P547, DOI 10.1038/s41440-018-0056-y
   Kokkinos A, 2013, OBES SURG, V23, P31, DOI 10.1007/s11695-012-0743-8
   Koren D, 2018, METABOLISM, V84, P67, DOI 10.1016/j.metabol.2018.04.001
   Koshino Y, 2013, OBESITY, V21, P1111, DOI 10.1002/oby.20168
   Kück JL, 2020, DIABETES, V69, P1011, DOI 10.2337/db19-0990
   Lakhani M, 2011, CARDIOL REV, V19, P1, DOI 10.1097/CRD.0b013e3181f877d2
   Lakkis JI, 2018, PROG CARDIOVASC DIS, V61, P157, DOI 10.1016/j.pcad.2018.07.005
   Lazarova Z, 2009, CAN J PHYSIOL PHARM, V87, P565, DOI [10.1139/y09-041, 10.1139/Y09-041]
   Li CH, 2020, OBES RES CLIN PRACT, V14, P158, DOI 10.1016/j.orcp.2020.02.003
   Li HX, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0167525
   Limberg JK, 2018, J APPL PHYSIOL, V124, P960, DOI 10.1152/japplphysiol.00918.2017
   Lopes HF, 2000, BRAZ J MED BIOL RES, V33, P51, DOI 10.1590/S0100-879X2000000100007
   Lucini D, 2006, J HYPERTENS, V24, P361, DOI 10.1097/01.hjh.0000202817.02836.9c
   Lumeng CN, 2011, J CLIN INVEST, V121, P2111, DOI 10.1172/JCI57132
   Man TF, 2021, AM J HYPERTENS, V34, P1276, DOI 10.1093/ajh/hpab122
   Mancia G, 2003, J HYPERTENS, V21, P1011, DOI 10.1097/01.hjh.0000059051.65882.32
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   Mengal V, 2016, HYPERTENS RES, V39, P769, DOI 10.1038/hr.2016.61
   Milovanovic B, 2011, ACTA PHYSIOL HUNG, V98, P71, DOI 10.1556/APhysiol.98.2011.1.9
   Monahan KD, 2007, AM J PHYSIOL-REG I, V293, pR3, DOI 10.1152/ajpregu.00031.2007
   Mostarda C, 2011, J CARD FAIL, V17, P519, DOI 10.1016/j.cardfail.2011.02.007
   Myers MG, 2008, ANNU REV PHYSIOL, V70, P537, DOI 10.1146/annurev.physiol.70.113006.100707
   Nakamura M, 2020, J PHYSIOL-LONDON, V598, P2977, DOI 10.1113/JP276747
   Okada N, 2010, CIRC J, V74, P1379, DOI 10.1253/circj.CJ-09-0960
   Ormezzano O, 2005, J HYPERTENS, V23, P2019, DOI 10.1097/01.hjh.0000184748.49189.36
   Ozemek C, 2020, PROG CARDIOVASC DIS, V63, P4, DOI 10.1016/j.pcad.2019.11.012
   Pal GK, 2013, AM J CARDIOL, V112, P1757, DOI 10.1016/j.amjcard.2013.07.040
   Pan YM, 2019, J DIABETES COMPLICAT, V33, P278, DOI 10.1016/j.jdiacomp.2018.12.014
   Pankova NB, 2020, INT J OCCUP MED ENV, V33, P819, DOI 10.13075/ijomeh.1896.01628
   PARMER RJ, 1992, CIRCULATION, V85, P497, DOI 10.1161/01.CIR.85.2.497
   Pierce GL, 2016, J HUM HYPERTENS, V30, P513, DOI 10.1038/jhh.2016.3
   Pinheiro A, 2021, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.613311
   Pinna GD, 2015, PHYSIOL MEAS, V36, P741, DOI 10.1088/0967-3334/36/4/741
   Raven PB, 2019, EXERC SPORT SCI REV, V47, P129, DOI 10.1249/JES.0000000000000190
   Rowaiye OO, 2013, CARDIOL J, V20, P453, DOI 10.5603/CJ.2013.0130
   Russo B, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22105187
   Sakamoto M, 2019, INT HEART J, V60, P241, DOI 10.1536/ihj.18-455
   Saku K, 2014, PHYSIOL REP, V2, DOI 10.14814/phy2.12136
   Schauer PR, 2017, NEW ENGL J MED, V376, P641, DOI 10.1056/NEJMoa1600869
   Schiavon CA, 2020, CURR HYPERTENS REP, V22, DOI 10.1007/s11906-020-01055-z
   Schiavon CA, 2018, CIRCULATION, V137, P1132, DOI 10.1161/CIRCULATIONAHA.117.032130
   Seravalle G, 2016, HIGH BLOOD PRESS CAR, V23, P175, DOI 10.1007/s40292-016-0137-4
   Seravalle G, 2014, HYPERTENSION, V64, P431, DOI 10.1161/HYPERTENSIONAHA.113.02988
   Serhiyenko VA, 2018, WORLD J DIABETES, V9, P1, DOI 10.4239/wjd.v9.i1.1
   Skrapari I, 2006, CURR DIABETES REV, V2, P329, DOI 10.2174/157339906777950589
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Straznicky NE, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00203
   Svitok P, 2016, HYPERTENS RES, V39, P501, DOI 10.1038/hr.2016.21
   Swenne CA, 2013, NETH HEART J, V21, P58, DOI 10.1007/s12471-012-0346-y
   Takahashi N, 2007, METABOLISM, V56, P919, DOI 10.1016/j.metabol.2007.02.005
   Taylor CE, 2014, ACTA PHYSIOL, V211, P297, DOI 10.1111/apha.12302
   Tentolouris N, 2008, NEUROMOL MED, V10, P169, DOI 10.1007/s12017-008-8022-5
   Thorp AA, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/341583
   Toschi-Dias E, 2019, SLEEP BREATH, V23, P143, DOI 10.1007/s11325-018-1675-x
   Trevano FQ, 2020, J HYPERTENS, V38, P565, DOI 10.1097/HJH.0000000000002288
   Verma AK, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00845
   Vinik AI, 2007, CIRCULATION, V115, P387, DOI 10.1161/CIRCULATIONAHA.106.634949
   Wang LC, 2021, OBES SURG, V31, P4970, DOI 10.1007/s11695-021-05671-9
   Yakhou L, 2006, J VASC SURG, V44, P472, DOI 10.1016/j.jvs.2006.06.004
   Yang XS, 2010, AM J HYPERTENS, V23, P655, DOI 10.1038/ajh.2010.30
   Ylitalo A, 2000, J AM COLL CARDIOL, V35, P194, DOI 10.1016/S0735-1097(99)00506-9
   Yufu K, 2011, CIRC J, V75, P1418, DOI 10.1253/circj.CJ-10-1122
   Zanoli L, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000002472
   Zhang LL, 2018, CNS NEUROSCI THER, V24, P828, DOI 10.1111/cns.12999
NR 102
TC 9
Z9 9
U1 0
U2 4
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD JAN
PY 2022
VL 23
IS 1
AR 67
DI 10.3892/etm.2021.10990
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA XL3DI
UT WOS:000728027300001
PM 34934438
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhan, LY
   Yin, HM
   Gao, YJ
   Li, Y
   Ma, J
AF Zhan, Luyu
   Yin, Huimin
   Gao, Yujun
   Li, Yi
   Ma, Jun
TI Prevalence and Factors Associated with Subclinical Hypothyroidism in
   Major Depressive Disorder Patients with Dyslipidemia
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Article
DE major depressive disorder; prevalence; dyslipidemia; subclinical
   hypothyroidism
ID METABOLIC SYNDROME; POPULATION; RISK
AB Background: Major depressive disorder (MDD) is a common psychiatric disorder with a high prevalence of comorbidity with subclinical hypothyroidism. The aim of this study was to investigate the prevalence and factors influencing the comorbidity of subclinical hypothyroidism in patients with dyslipidemic MDD who were hospitalized for the first time in a Chinese population. Methods: The study incorporated 708 first-time hospitalized MDD patients, all with dyslipidemia. Data collection encompassed socio-demographic information, blood pressure, fasting blood glucose (FBG), lipid, and thyroid hormone levels. Participants were evaluated using the Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and Positive Symptom Subscale (PSS). Results: The prevalence of subclinical hypothyroidism in dyslipidemic MDD patients with the first hospitalization was 39.97%. The course of the disease, age at onset, HAMA score, and low-density lipoprotein cholesterol (LDL-C) were risk factors for subclinical hypothyroidism in dyslipidemic MDD patients. The course of disease, age at onset, HAMA score, HAMD score, FBG, and systolic blood pressure (SBP) levels were observed to influence serum Thyroid Stimulating Hormone (TSH) levels.Conclusion: MDD patients with dyslipidemia have a high prevalence of subclinical hypothyroidism, and the outcome is associated with anxiety, fasting glucose, and lipids. This study provides a potential biomarker for the identification of co-morbid subclinical hypothyroidism in MDD patients with dyslipidaemia.
C1 [Zhan, Luyu; Yin, Huimin; Li, Yi; Ma, Jun] Anhui Med Univ, Sch Mental Hlth & Psychol Sci, Wuhan Mental Hlth Ctr, Wuhan, Peoples R China.
   [Gao, Yujun; Ma, Jun] Wuhan Mental Hlth Ctr, Dept Psychiat, Wuhan, Peoples R China.
   [Li, Yi; Ma, Jun] Wuhan Univ, Renmin Hosp, Dept Psychiat, Wuhan, Peoples R China.
   [Li, Yi; Ma, Jun] Wuhan Mental Hlth Ctr, 89 Gongnongbing Rd, Wuhan 430012, Hubei, Peoples R China.
C3 Anhui Medical University; Wuhan University
RP Li, Y; Ma, J (corresponding author), Anhui Med Univ, Sch Mental Hlth & Psychol Sci, Wuhan Mental Hlth Ctr, Wuhan, Peoples R China.; Li, Y; Ma, J (corresponding author), Wuhan Mental Hlth Ctr, 89 Gongnongbing Rd, Wuhan 430012, Hubei, Peoples R China.
EM psylee@163.com; majun0313@msn.cn
RI Ma, Jun/HLV-7600-2023
OI Ma, Jun/0000-0001-5633-6839
CR Ramírez LA, 2018, BIOMEDICA, V38, P437, DOI 10.7705/biomedica.v38i3.3688
   [Anonymous], 2016, Chin J Cardiol, V44, P833, DOI [10.3760/cma.j.issn.0253-3758.2016.10.005, DOI 10.3760/CMA.J.ISSN.0253-3758.2016.10.005]
   Ayuob NN, 2019, ROM J MORPHOL EMBRYO, V60, P921
   Berta E, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00482
   Burch HB, 2019, NEW ENGL J MED, V381, P749, DOI 10.1056/NEJMra1901214
   Chien IC, 2013, J PSYCHOSOM RES, V75, P270, DOI 10.1016/j.jpsychores.2013.06.003
   Choi KW, 2019, THYROID, V29, P1713, DOI 10.1089/thy.2019.0091
   Dai WY, 2023, J AFFECT DISORDERS, V333, P209, DOI 10.1016/j.jad.2023.04.067
   Duntas LH, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00511
   Ferrari AJ, 2022, LANCET PSYCHIAT, V9, P137, DOI 10.1016/S2215-0366(21)00395-3
   Fliers E, 2006, MOL CELL ENDOCRINOL, V251, P1, DOI 10.1016/j.mce.2006.03.042
   Pato CM, 2017, REV PSIQUIATR SALUD, V10, P38, DOI 10.1016/j.rpsm.2016.09.003
   Fugger G, 2018, EUR NEUROPSYCHOPHARM, V28, P752, DOI 10.1016/j.euroneuro.2018.03.011
   Gaitonde DY, 2012, S AFR FAM PRACT, V54, P384, DOI 10.1080/20786204.2012.10874256
   Geraets AFJ, 2022, J AFFECT DISORDERS, V313, P110, DOI 10.1016/j.jad.2022.06.045
   Goldstein BI, 2015, CIRCULATION, V132, P965, DOI 10.1161/CIR.0000000000000229
   Gorkhali Binu, 2020, J Nepal Health Res Counc, V18, P373, DOI 10.33314/jnhrc.v18i3.2499
   Grais IM, 2014, AM J MED, V127, P691, DOI 10.1016/j.amjmed.2014.03.009
   Huang YQ, 2019, LANCET PSYCHIAT, V6, P211, DOI 10.1016/S2215-0366(18)30511-X
   Kalra S, 2021, INT J ENDOCRINOL, V2021, DOI 10.1155/2021/9641846
   Karakatsoulis GN, 2021, HORM-INT J ENDOCRINO, V20, P613, DOI 10.1007/s42000-021-00312-3
   Khazan M, 2014, HORM METAB RES, V46, P980, DOI 10.1055/s-0034-1389997
   Kopin L, 2017, ANN INTERN MED, V167, pITC81, DOI 10.7326/AITC201712050
   Lang XE, 2020, J AFFECT DISORDERS, V263, P507, DOI 10.1016/j.jad.2019.11.004
   Laursen TM, 2014, ANNU REV CLIN PSYCHO, V10, P425, DOI 10.1146/annurev-clinpsy-032813-153657
   Lei Y, 2019, J CLIN LAB ANAL, V33, DOI 10.1002/jcla.22929
   Lemche AV, 2017, J ENDOCRINOL INVEST, V40, P539, DOI 10.1007/s40618-016-0601-y
   Li H, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0243847
   Li XA, 2017, ENDOCR J, V64, P437, DOI 10.1507/endocrj.EJ16-0549
   Luo GS, 2023, J AFFECT DISORDERS, V335, P298, DOI 10.1016/j.jad.2023.05.008
   Malhi GS, 2018, LANCET, V392, P2299, DOI 10.1016/S0140-6736(18)31948-2
   Marazziti D, 2014, CNS SPECTRUMS, V19, P293, DOI 10.1017/S1092852913000667
   Melo APS, 2022, LANCET PSYCHIAT, V9, P771, DOI 10.1016/S2215-0366(22)00237-1
   Mills JG, 2020, APPETITE, V148, DOI 10.1016/j.appet.2020.104586
   Naicker M, 2019, METAB BRAIN DIS, V34, P1281, DOI 10.1007/s11011-019-00437-w
   Ng QX, 2020, BIPOLAR DISORD, V22, P638, DOI 10.1111/bdi.12960
   Nuguru SP, 2022, CUREUS J MED SCIENCE, V14, DOI 10.7759/cureus.28201
   Parekh A, 2017, HEALTHCARE-BASEL, V5, DOI 10.3390/healthcare5010005
   Persons JE, 2016, J AFFECT DISORDERS, V206, P55, DOI 10.1016/j.jad.2016.07.033
   Qiao D, 2022, J AFFECT DISORDERS, V299, P159, DOI 10.1016/j.jad.2021.11.055
   Shao SS, 2014, ACTA PHARMACOL SIN, V35, P1411, DOI 10.1038/aps.2014.82
   Song YF, 2021, CELL METAB, V33, P1911, DOI 10.1016/j.cmet.2021.09.001
   Tanner JA, 2020, CAN J PSYCHIAT, V65, P338, DOI 10.1177/0706743719895342
   Vishnoi G, 2014, ASIAN J PSYCHIATR, V8, P89, DOI 10.1016/j.ajp.2013.12.004
   Wang QJ, 2023, J AFFECT DISORDERS, V328, P135, DOI 10.1016/j.jad.2023.02.068
   Wang X, 2023, J AFFECT DISORDERS, V325, P306, DOI 10.1016/j.jad.2023.01.032
   Yang J, 2016, J NEUROENDOCRINOL, V28, DOI 10.1111/jne.12369
   Yang L, 2021, PSYCHIAT RES, V305, DOI 10.1016/j.psychres.2021.114205
   Yang RC, 2022, FRONT PSYCHIATRY, V13, DOI 10.3389/fpsyt.2022.920723
   Zhao M, 2015, J CLIN ENDOCR METAB, V100, P1887, DOI 10.1210/jc.2014-3987
   Zhao M, 2015, THYROID, V25, P485, DOI 10.1089/thy.2014.0219
   Zhu QF, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-35290-6
NR 52
TC 6
Z9 6
U1 2
U2 7
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2023
VL 19
BP 2309
EP 2318
DI 10.2147/NDT.S435138
PG 10
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA X8RN2
UT WOS:001101057900001
PM 37920820
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zamora, M
   Sabado-Liwag, M
AF Zamora, Mayra
   Sabado-Liwag, Melanie
TI Mental Health and PCOS Information-Sharing: Interviews with Health Care
   Providers in a Low-Income Urban Community
SO JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
LA English
DT Article
DE Polycystic ovary syndrome; Mental health; Hispanics; Latinas;
   Information-sharing; Healthcare delivery
ID POLYCYSTIC-OVARY-SYNDROME; QUALITY-OF-LIFE; PSYCHOLOGICAL DISTRESS;
   METABOLIC SYNDROME; WOMEN; DEPRESSION; PREVALENCE; PHYSICIANS;
   KNOWLEDGE; SYMPTOMS
AB Polycystic ovary syndrome (PCOS) is a female metabolic-endocrine disorder typically characterized by menstrual dysfunction, hyperandrogenism, and/or polycystic ovaries. While comorbidity with poor mental health is often observed, it is less understood if women of color are given information on PCOS, mental health, or both by healthcare providers. This paper examines the information-sharing practices of healthcare providers serving a low-income, predominantly Latino/Hispanic municipality in Southeast Los Angeles, CA. Of 65 providers identified across 27 clinics in the service area, four participated in one-on-one semi-structured interviews. Four themes relating to PCOS and mental health information were identified using content analysis. Results suggest that information-sharing on PCOS is limited to symptomatic patients and varies by provider specialization. Poor mental health as a side effect of PCOS is not elaborated on during patient-provider interactions within the explored service area. Implications and directions for further research are discussed, including mixed methods approaches for contextual information on PCOS among women of color and recommendations for improving communication among healthcare providers.
C1 [Zamora, Mayra; Sabado-Liwag, Melanie] Calif State Univ Los Angeles, Dept Publ Hlth, Los Angeles, CA 90032 USA.
C3 Los Angeles County Department of Public Health; California State
   University System; California State University Los Angeles
RP Sabado-Liwag, M (corresponding author), Calif State Univ Los Angeles, Dept Publ Hlth, Los Angeles, CA 90032 USA.
EM msabado@calstatela.edu
OI Sabado-Liwag, Melanie D./0000-0001-8026-7212
CR Berni TR, 2018, J CLIN ENDOCR METAB, V103, P2116, DOI 10.1210/jc.2017-02667
   Bhat A, 2017, OBSTET GYNECOL, V129, P157, DOI 10.1097/AOG.0000000000001809
   Brutocao C, 2018, ENDOCRINE, V62, P318, DOI 10.1007/s12020-018-1692-3
   Calderon Jose L, 2006, MedGenMed, V8, P23
   Cesta CE, 2016, PSYCHONEUROENDOCRINO, V73, P196, DOI 10.1016/j.psyneuen.2016.08.005
   Chaudhari AP, 2018, INDIAN J PSYCHOL MED, V40, P239, DOI 10.4103/IJPSYM.IJPSYM_561_17
   Cooney LG, 2017, HUM REPROD, V32, P1075, DOI 10.1093/humrep/dex044
   Dokras A, 2017, FERTIL STERIL, V107, P1380, DOI 10.1016/j.fertnstert.2017.04.011
   Eberhart Nicole K, 2019, Rand Health Q, V8, P5
   Erlingsson C, 2017, AFR J EMERG MED, V7, P93, DOI 10.1016/j.afjem.2017.08.001
   Escarce JoseJ., 2006, Hispanics and the Future of America
   Fernandez RC, 2018, NAT SCI SLEEP, V10, P45, DOI 10.2147/NSS.S127475
   George S, 2014, AM J PUBLIC HEALTH, V104, pE16, DOI 10.2105/AJPH.2013.301706
   Gibson-Helm M, 2018, SEMIN REPROD MED, V36, P19, DOI 10.1055/s-0038-1667155
   Gibson-Helm M, 2018, SEMIN REPROD MED, V36, P35, DOI 10.1055/s-0038-1668086
   Gibson-Helm M, 2017, J CLIN ENDOCR METAB, V102, P604, DOI 10.1210/jc.2016-2963
   Greenwood EA, 2019, FERTIL STERIL, V111, P147, DOI 10.1016/j.fertnstert.2018.10.004
   Greenwood EA, 2015, FERTIL STERIL, V104, P707, DOI 10.1016/j.fertnstert.2015.05.019
   Hadjiconstantinou M, 2017, ENDOCR CONNECT, V6, P323, DOI 10.1530/EC-17-0053
   Hallajzadeh J, 2018, J CARDIOVASC THORAC, V10, P56, DOI 10.15171/jcvtr.2018.10
   Jones GL, 2011, JOGNN-J OBST GYN NEO, V40, P577, DOI 10.1111/j.1552-6909.2011.01279.x
   Karjula S, 2017, J CLIN ENDOCR METAB, V102, P1861, DOI 10.1210/jc.2016-3863
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Kutner M., 2006, HLTH LITERACY AM ADU
   Leigh W, 2014, WOMEN COLOR HLTH DAT
   Lim SS, 2012, HUM REPROD UPDATE, V18, P618, DOI 10.1093/humupd/dms030
   Los Angeles County Department of Public Health, 2015, ANG COUNT HLTH SURV
   Los Angeles County Department of Public Health, 2018, CIT COMM HLTH PROF H
   McCartney CR, 2016, NEW ENGL J MED, V375, P54, DOI 10.1056/NEJMcp1514916
   Melville JL, 2014, OBSTET GYNECOL, V123, P1237, DOI 10.1097/AOG.0000000000000231
   Meyer ML, 2020, J CLIN ENDOCR METAB, V105, pE447, DOI 10.1210/clinem/dgaa012
   Palomba S, 2015, INT J WOMENS HEALTH, V7, P745, DOI 10.2147/IJWH.S70314
   Rahman S, 2011, ADV MED EDUC PRACT, V2, P85, DOI 10.2147/AMEP.S14103
   Rassi A, 2010, COMPR PSYCHIAT, V51, P599, DOI 10.1016/j.comppsych.2010.02.009
   Rowlands IJ, 2016, HUM REPROD, V31, P2072, DOI 10.1093/humrep/dew174
   Sanchez N, 2020, HEALTH SOC WORK, V45, P40, DOI 10.1093/hsw/hlz033
   Sills E Scott, 2001, BMC Womens Health, V1, P3, DOI 10.1186/1472-6874-1-3
   U.S. Census Bureau, QUICKFACTS ANG COUNT
   U.S. Census Bureau, 2018, Census Reporter
   Velasco-Mondragon E, 2016, PUBLIC HEALTH REV, V37, DOI 10.1186/s40985-016-0043-2
   Wang S, 2006, HEALTH PROMOT INT, V21, P76, DOI 10.1093/heapro/dai025
   Williams Sophie, 2015, Health Psychol Open, V2, p2055102915603051, DOI 10.1177/2055102915603051
   Wolf WM, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15112589
   Zamora M, 2020, APPENDIX SEMISTRUCTU, DOI [10.6084/m9.figshare.13292087.v5, DOI 10.6084/M9.FIGSHARE.13292087.V5]
NR 44
TC 1
Z9 1
U1 3
U2 9
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 2197-3792
EI 2196-8837
J9 J RACIAL ETHN HEALTH
JI J. Racial Ethn. Health Disparities
PD JUN
PY 2023
VL 10
IS 3
BP 1086
EP 1095
DI 10.1007/s40615-022-01295-6
EA MAY 2022
PG 10
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA F8ND3
UT WOS:000792556200001
PM 35534681
DA 2025-06-11
ER

PT J
AU Li, RQ
   Zhan, WQ
   Huang, X
   Liu, Z
   Lv, SS
   Wang, JQ
   Liang, LY
   Ma, YX
AF Li, Ruiqiang
   Zhan, Wenqiang
   Huang, Xin
   Liu, Zhan
   Lv, Shuaishuai
   Wang, Jiaqi
   Liang, Luyao
   Ma, Yuxia
TI Association of Dietary Inflammatory Index (DII) and Depressive Disorders
SO JOURNAL OF INFLAMMATION RESEARCH
LA English
DT Review
DE dietary inflammatory index; depressive disorders; inflammation
ID STOP HYPERTENSION DASH; HEALTHY EATING INDEX; MEDITERRANEAN DIET;
   OLDER-ADULTS; METABOLIC SYNDROME; COGNITIVE DECLINE; PHYSICAL-ACTIVITY;
   OXIDATIVE STRESS; NATIONAL-HEALTH; MENTAL-HEALTH
AB A lot of evidence shows that inflammation is related to the development of depression. However, the heterogeneity of depression hinders efforts to understand, prevent and treat this disease. The purpose of this comprehensive review is to summarize the links between inflammation and the established core features of depression, which show more homogeneity than the syndrome itself: overreaction to negative information, changes in reward processing, and cognitive control decline, and somatic syndrome. For each core feature, we first briefly outline its relevance to depression and neurobiological basis, and then review the evidence to investigate the potential role of inflammation. We mainly focus on the discovery of the experimental paradigm of exogenous inflammation. We concluded that inflammation may play a role in overreaction to negative information, altered reward responses, and physical symptoms. There is less evidence to support the effect of inflammation on cognitive control by standard neuropsychological measures. Finally, we discussed the implications for future research and recommendations on how to test the role of inflammation in the pathogenesis of heterogeneous mental illness.
C1 [Li, Ruiqiang; Huang, Xin; Liu, Zhan; Lv, Shuaishuai; Wang, Jiaqi; Liang, Luyao; Ma, Yuxia] Hebei Med Univ, Sch Publ Hlth, Hebei Prov Key Lab Environm & Human Hlth, Dept Nutr & Food Hyg, Shijiazhuang, Hebei, Peoples R China.
   [Zhan, Wenqiang] Shanghai Jiao Tong Univ, Sch Publ Hlth, Sch Med, Shanghai 200025, Peoples R China.
C3 Hebei Medical University; Shanghai Jiao Tong University
RP Ma, YX (corresponding author), Hebei Med Univ, Sch Publ Hlth, Hebei Prov Key Lab Environm & Human Hlth, Dept Nutr & Food Hyg, Shijiazhuang, Hebei, Peoples R China.
EM mayuxia@hebmu.edu.cn
RI Wang, Xianlong/AFU-4519-2022
FU  [2017YFC0907701]
FX Community Cohort Study on Specialized Nervous System Diseases
   (No.2017YFC0907701).
CR Accardi G, 2019, NUTRITION, V63-64, P205, DOI 10.1016/j.nut.2019.02.008
   Akbaraly TN, 2016, CLIN PSYCHOL SCI, V4, P1125, DOI 10.1177/2167702616645777
   Aleksandrova K, 2021, REDOX BIOL, V42, DOI 10.1016/j.redox.2021.101869
   Almeida-de-Souza J, 2018, EUR J CLIN NUTR, V72, P710, DOI 10.1038/s41430-017-0013-x
   Anderson KM, 2020, P NATL ACAD SCI USA, V117, P25138, DOI 10.1073/pnas.2008004117
   Ariya M, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-73844-0
   Arouca AB, 2020, CLIN NUTR, V39, P1919, DOI 10.1016/j.clnu.2019.08.016
   Asemi Z, 2013, NUTRITION, V29, P619, DOI 10.1016/j.nut.2012.11.020
   Aslani Z, 2020, MENOPAUSE, V27, P568, DOI 10.1097/GME.0000000000001502
   Astbury CC, 2019, INT J BEHAV NUTR PHY, V16, DOI 10.1186/s12966-019-0846-x
   Attwells S, 2017, JAMA PSYCHIAT, V74, P833, DOI 10.1001/jamapsychiatry.2017.1567
   Bédard A, 2015, NUTR J, V14, DOI 10.1186/s12937-015-0035-y
   Bergmans RS, 2017, PREV MED, V99, P313, DOI 10.1016/j.ypmed.2017.03.016
   Berk M, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-200
   Beurel E, 2020, NEURON, V107, P234, DOI 10.1016/j.neuron.2020.06.002
   Bondonno NP, 2020, EUR J NUTR, V59, P3201, DOI 10.1007/s00394-019-02160-9
   Bradburn S, 2018, FRONT AGING NEUROSCI, V9, DOI 10.3389/fnagi.2017.00438
   Bremner JD, 2020, NUTRIENTS, V12, DOI 10.3390/nu12082428
   Burrows K, 2020, J AFFECT DISORDERS, V263, P99, DOI 10.1016/j.jad.2019.11.160
   Buschmann K, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/5724024
   Casey DA, 2017, PRIMARY CARE, V44, P499, DOI 10.1016/j.pop.2017.04.007
   Cervo MM, 2020, CLIN NUTR, V39, P516, DOI 10.1016/j.clnu.2019.02.031
   Chen X, 2019, J ALZHEIMERS DIS, V67, P583, DOI 10.3233/JAD-180468
   Colasanto M, 2020, J AFFECT DISORDERS, V277, P940, DOI 10.1016/j.jad.2020.09.025
   Crimarco Anthony, 2019, Nutrition and Health (Bicester), V25, P9, DOI 10.1177/0260106018800645
   D'Mello C, 2017, CURR TOP BEHAV NEURO, V31, P73, DOI 10.1007/7854_2016_37
   Dash S, 2015, CURR OPIN PSYCHIATR, V28, P1, DOI 10.1097/YCO.0000000000000117
   Féart C, 2009, JAMA-J AM MED ASSOC, V302, P638, DOI 10.1001/jama.2009.1146
   Felger JC, 2020, MOL PSYCHIATR, V25, P1301, DOI 10.1038/s41380-018-0096-3
   Ferguson CC, 2021, CLIN NUTR, V40, P4085, DOI 10.1016/j.clnu.2021.02.008
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Frühbeck G, 2013, OBESITY FACTS, V6, P117, DOI 10.1159/000350627
   Galbete C, 2018, BMC MED, V16, DOI 10.1186/s12916-018-1082-y
   García-Toro M, 2016, J AFFECT DISORDERS, V194, P105, DOI 10.1016/j.jad.2015.12.064
   Ghazizadeh H, 2020, BMC PSYCHIATRY, V20, DOI 10.1186/s12888-020-02663-4
   Ghorabi S, 2020, J CARDIOVASC THORAC, V12, P27, DOI 10.34172/jcvtr.2020.05
   Gomes AP, 2021, CLIN NUTR, V40, P2800, DOI 10.1016/j.clnu.2021.03.028
   Guan YF, 2020, BRAIN BEHAV IMMUN, V88, P748, DOI 10.1016/j.bbi.2020.05.032
   Haghighatdoost F, 2019, CLIN NUTR, V38, P1643, DOI 10.1016/j.clnu.2018.08.016
   Halaris A, 2019, CURR OPIN PSYCHIATR, V32, P422, DOI 10.1097/YCO.0000000000000531
   Halaris A, 2017, CURR TOP BEHAV NEURO, V31, P45, DOI 10.1007/7854_2016_28
   Hariri N, 2020, PHYTOTHER RES, V34, P3041, DOI 10.1002/ptr.6737
   Hart MJ, 2021, EUR J NUTR, V60, P4093, DOI 10.1007/s00394-021-02573-5
   He CC, 2019, BRAIN IMAGING BEHAV, V13, P1146, DOI 10.1007/s11682-018-9923-z
   Hornedo-Ortega R, 2018, FRONT CELL NEUROSCI, V12, DOI 10.3389/fncel.2018.00373
   Jorgensen D, 2018, NUTR RES, V54, P23, DOI 10.1016/j.nutres.2018.03.004
   Karimbeiki R, 2021, INT J CLIN PRACT, DOI 10.1111/ijcp.14567
   Kerr J, 2017, LANCET ONCOL, V18, pE457, DOI 10.1016/S1470-2045(17)30411-4
   Kiecolt-Glaser JK, 2015, AM J PSYCHIAT, V172, P1075, DOI 10.1176/appi.ajp.2015.15020152
   King DE, 2019, J AM BOARD FAM MED, V32, P801, DOI 10.3122/jabfm.2019.06.190092
   Köhler O, 2016, CURR NEUROPHARMACOL, V14, P732, DOI 10.2174/1570159X14666151208113700
   Koopman M, 2017, CURR OPIN PSYCHIATR, V30, P369, DOI 10.1097/YCO.0000000000000350
   Kotzbeck P, 2018, J LIPID RES, V59, P784, DOI 10.1194/jlr.M079665
   Krebs-Smith SM, 2018, J ACAD NUTR DIET, V118, P1591, DOI 10.1016/j.jand.2018.05.021
   Laouali N, 2019, DIABETOLOGIA, V62, P2222, DOI 10.1007/s00125-019-04972-0
   Lassale C, 2019, MOL PSYCHIATR, V24, P965, DOI 10.1038/s41380-018-0237-8
   Leff-Gelman P, 2016, NEUROSCI BULL, V32, P398, DOI 10.1007/s12264-016-0048-3
   Leonard BE, 2018, ACTA NEUROPSYCHIATR, V30, P1, DOI 10.1017/neu.2016.69
   Li Y, 2017, PSYCHIAT RES, V253, P373, DOI 10.1016/j.psychres.2017.04.020
   Lin DF, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/2491927
   Lopresti AL, 2013, J AFFECT DISORDERS, V148, P12, DOI 10.1016/j.jad.2013.01.014
   Lourida I, 2013, EPIDEMIOLOGY, V24, P479, DOI 10.1097/EDE.0b013e3182944410
   Ma WJ, 2020, CLIN GASTROENTEROL H, V18, P2279, DOI 10.1016/j.cgh.2019.11.011
   MacDonald CJ, 2020, NUTR J, V19, DOI 10.1186/s12937-020-00577-1
   Majd M, 2020, FRONT NEUROENDOCRIN, V56, DOI 10.1016/j.yfrne.2019.100800
   Malcomson FC, 2021, CANCER PREV RES, V14, P337, DOI 10.1158/1940-6207.CAPR-20-0335
   Marx W, 2021, MOL PSYCHIATR, V26, P134, DOI 10.1038/s41380-020-00925-x
   Matta J, 2019, J AFFECT DISORDERS, V244, P25, DOI 10.1016/j.jad.2018.09.072
   Mickle AT, 2019, J NUTR SCI, V8, DOI 10.1017/jns.2019.32
   Miller AH, 2009, BIOL PSYCHIAT, V65, P732, DOI 10.1016/j.biopsych.2008.11.029
   Molendijk M, 2018, J AFFECT DISORDERS, V226, P346, DOI 10.1016/j.jad.2017.09.022
   Morze J, 2020, J ACAD NUTR DIET, V120, P1998, DOI 10.1016/j.jand.2020.08.076
   Muhammad HFL, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010148
   Nasab SJ, 2021, BMC CANCER, V21, DOI 10.1186/s12885-021-08786-5
   Navarro P, 2020, PEDIATR OBES, V15, DOI 10.1111/ijpo.12588
   Navarro P, 2020, CLIN NUTR, V39, P2169, DOI 10.1016/j.clnu.2019.09.004
   Nilsson A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11040805
   Null G, 2017, COMPLEMENT THER CLIN, V29, P189, DOI 10.1016/j.ctcp.2017.09.007
   Oddy WH, 2018, BRAIN BEHAV IMMUN, V69, P428, DOI 10.1016/j.bbi.2018.01.002
   Opie RS, 2015, PUBLIC HEALTH NUTR, V18, P2074, DOI 10.1017/S1368980014002614
   Owen L, 2017, P NUTR SOC, V76, P425, DOI 10.1017/S0029665117001057
   Parletta N, 2019, NUTR NEUROSCI, V22, P474, DOI 10.1080/1028415X.2017.1411320
   Phillips CM, 2018, CLIN NUTR, V37, P1485, DOI 10.1016/j.clnu.2017.08.029
   Pirouzeh R, 2020, DIABETES METAB SYND, V14, P2131, DOI 10.1016/j.dsx.2020.10.031
   Qin Z, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.720834
   Quirk SE, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-175
   Reedy J, 2018, J ACAD NUTR DIET, V118, P1622, DOI 10.1016/j.jand.2018.05.019
   Rensma SP, 2020, HYPERTENSION, V75, P237, DOI 10.1161/HYPERTENSIONAHA.119.13023
   Repple J, 2020, MOL PSYCHIATR, V25, P1550, DOI 10.1038/s41380-019-0603-1
   Robaczewska J, 2016, REDOX REP, V21, P209, DOI 10.1080/13510002.2015.1101889
   Ruiz-Canela M, 2015, BRIT J NUTR, V113, P984, DOI 10.1017/S0007114514004401
   Ruiz-Saavedra S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12123828
   Sacks FM, 2001, NEW ENGL J MED, V344, P3, DOI 10.1056/NEJM200101043440101
   Salari-Moghaddam A, 2019, CLIN NUTR, V38, P2360, DOI 10.1016/j.clnu.2018.10.015
   Sanada K, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21072484
   Sánchez-Villegas A, 2015, BRIT J NUTR, V114, P1471, DOI 10.1017/S0007114515003074
   Schwingshackl L, 2018, J ACAD NUTR DIET, V118, P74, DOI 10.1016/j.jand.2017.08.024
   Scridon A, 2015, INFLAMM RES, V64, P383, DOI 10.1007/s00011-015-0827-8
   Shabbir F, 2013, NEUROCHEM INT, V62, P324, DOI 10.1016/j.neuint.2012.12.014
   Shah R, 2009, DIABETES, V58, P2211, DOI 10.2337/db09-0256
   Shah R, 2020, NUTR RES, V75, P77, DOI 10.1016/j.nutres.2020.01.004
   Shakya PR, 2021, CLIN NUTR, V40, P3631, DOI 10.1016/j.clnu.2020.12.031
   Shimbo D, 2005, AM J CARDIOL, V96, P1016, DOI 10.1016/j.amjcard.2005.05.064
   Shivappa N, 2019, EUR J NUTR, V58, P797, DOI 10.1007/s00394-018-1690-5
   Shivappa N, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600707
   Shivappa N, 2014, PUBLIC HEALTH NUTR, V17, P1689, DOI 10.1017/S1368980013002115
   Smith Kerri, 2014, Nature, V515, P181, DOI 10.1038/515180a
   Smith KJ, 2018, EXP GERONTOL, V102, P109, DOI 10.1016/j.exger.2017.12.005
   Sofi F, 2014, PUBLIC HEALTH NUTR, V17, P2769, DOI 10.1017/S1368980013003169
   Soltani S, 2018, CLIN NUTR, V37, P542, DOI 10.1016/j.clnu.2017.02.018
   Stanners MN, 2014, BMC FAM PRACT, V15, DOI 10.1186/1471-2296-15-124
   Taylor AM, 2020, NUTR NEUROSCI, V23, P237, DOI 10.1080/1028415X.2018.1493808
   Turner-McGrievy GM, 2019, CLIN NUTR ESPEN, V30, P42, DOI 10.1016/j.clnesp.2019.02.008
   Turner-McGrievy GM, 2015, NUTR RES, V35, P97, DOI 10.1016/j.nutres.2014.11.007
   Valls-Pedret C, 2015, JAMA INTERN MED, V175, P1094, DOI 10.1001/jamainternmed.2015.1668
   Wang T, 2021, CLIN NUTR, V40, P2285, DOI 10.1016/j.clnu.2020.10.017
   Weerahandi H, 2020, JMIR FORM RES, V4, DOI 10.2196/13989
   Widmer RJ, 2015, AM J MED, V128, P229, DOI 10.1016/j.amjmed.2014.10.014
   Wirth MD, 2017, HEALTH PSYCHOL, V36, P760, DOI 10.1037/hea0000514
   Wittenborn AK, 2016, PSYCHOL MED, V46, P551, DOI 10.1017/S0033291715002044
   Wlodarczyk A, 2019, NEUROSCI BIOBEHAV R, V107, P422, DOI 10.1016/j.neubiorev.2019.09.038
   Wu PY, 2020, NUTR NEUROSCI, V23, P101, DOI 10.1080/1028415X.2018.1477424
   Zade MR, 2016, LIVER INT, V36, P563, DOI 10.1111/liv.12990
   Zainal NH, 2021, J ABNORM PSYCHOL, V130, P829, DOI 10.1037/abn0000716
   Zhang JC, 2016, CURR NEUROPHARMACOL, V14, P721, DOI 10.2174/1570159X14666160119094646
NR 125
TC 10
Z9 10
U1 4
U2 21
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-7031
J9 J INFLAMM RES
JI J. Inflamm. Res.
PY 2021
VL 14
BP 6959
EP 6973
DI 10.2147/JIR.S344002
PG 15
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology
GA XU1WN
UT WOS:000734064400001
PM 34949933
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Proeschold-Bell, RJ
   Turner, EL
   Bennett, GG
   Yao, J
   Li, XF
   Eagle, DE
   Meyer, RA
   Williams, RB
   Swift, RY
   Moore, HE
   Kolkin, MA
   Weisner, CC
   Rugani, KM
   Hough, HJ
   Williams, VP
   Toole, DC
AF Proeschold-Bell, Rae Jean
   Turner, Elizabeth L.
   Bennett, Gary G.
   Yao, Jia
   Li, Xiang-Fang
   Eagle, David E.
   Meyer, Rachel A.
   Williams, Redford B.
   Swift, Robin Y.
   Moore, H. Edgar
   Kolkin, Melanie A.
   Weisner, Carl C.
   Rugani, Katherine M.
   Hough, Holly J.
   Williams, Virginia P.
   Toole, David C.
TI A 2-Year Holistic Health and Stress Intervention: Results of an RCT in
   Clergy
SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE
LA English
DT Article
ID WEIGHT-LOSS; METABOLIC SYNDROME; CLINICAL-TRIALS; HIGH-RATES; RISK;
   OBESITY; METAANALYSIS; OVERWEIGHT; DEPRESSION; MANAGEMENT
AB Introduction: This study sought to determine the effect of a 2-year, multicomponent health intervention (Spirited Life) targeting metabolic syndrome and stress simultaneously.
   Design: An RCT using a three-cohort multiple baseline design was conducted in 2010-2014.
   Setting/participants: Participants were United Methodist clergy in North Carolina, U. S., in 2010, invited based on occupational status. Of invited 1,745 clergy, 1,114 consented, provided baseline data, and were randomly assigned to immediate intervention (n = 395), 1-year waitlist (n = 283), or 2-year waitlist (n = 436) cohorts for a 48-month trial duration.
   Intervention: The 2-year intervention consisted of personal goal setting and encouragement to engage in monthly health coaching, an online weight loss intervention, a small grant, and three workshops delivering stress management and theological content supporting healthy behaviors. Participants were not blinded to intervention.
   Main outcome measures: Trial outcomes were metabolic syndrome (primary) and self-reported stress and depressive symptoms (secondary). Intervention effects were estimated in 2016 in an intention-to-treat framework using generalized estimating equations with adjustment for baseline level of the outcome and follow-up time points. Log-link Poisson generalized estimating equations with robust SEs was used to estimate prevalence ratios (PRs) for binary outcomes; mean differences were used for continuous/score outcomes.
   Results: Baseline prevalence of metabolic syndrome was 50.9% and depression was 11.4%. The 12-month intervention effect showed a benefit for metabolic syndrome (PR = 0.86, 95% CI = 0.79, 0.94, p<0.001). This benefit was sustained at 24 months of intervention (PR = 0.88; 95% CI = 0.78, 1.00, p = 0.04). There was no significant effect on depression or stress scores.
   Conclusions: The Spirited Life intervention improved metabolic syndrome prevalence in a population of U. S. Christian clergy and sustained improvements during 24 months of intervention. These findings offer support for long-duration behavior change interventions and population-level interventions that allow participants to set their own health goals.
C1 [Proeschold-Bell, Rae Jean; Yao, Jia; Eagle, David E.] Duke Ctr Hlth Policy & Inequal Res, Duke Global Hlth Inst, Box 90392, Durham, NC 27708 USA.
   [Turner, Elizabeth L.] Duke Univ, Dept Biostat & Bioinformat, Durham, NC USA.
   [Turner, Elizabeth L.; Bennett, Gary G.; Toole, David C.] Duke Univ, Duke Global Hlth Inst, Durham, NC USA.
   [Bennett, Gary G.; Williams, Redford B.] Duke Univ, Dept Psychol & Neurosci, Durham, NC USA.
   [Li, Xiang-Fang; Meyer, Rachel A.; Swift, Robin Y.; Moore, H. Edgar; Kolkin, Melanie A.; Weisner, Carl C.; Rugani, Katherine M.; Hough, Holly J.; Toole, David C.] Duke Divin Sch, Durham, NC USA.
   [Williams, Redford B.] Duke Univ, Dept Psychiat & Behav Sci, Durham, NC USA.
   [Williams, Redford B.] Duke Univ, Behav Med Res Ctr, Durham, NC USA.
   [Williams, Redford B.; Williams, Virginia P.] Williams LifeSkills Inc, Durham, NC USA.
C3 Duke University; Duke University; Duke University; Duke University; Duke
   University; Duke University; Duke University
RP Proeschold-Bell, RJ (corresponding author), Duke Ctr Hlth Policy & Inequal Res, Duke Global Hlth Inst, Box 90392, Durham, NC 27708 USA.
EM rae.jean@duke.edu
RI Eagle, David/AAG-9344-2021
OI Turner, Elizabeth/0000-0002-7638-5942; Yao, Jia/0000-0001-8724-577X
FU Rural Church Area of The Duke Endowment
FX The United Methodist clergy of North Carolina, along with support from
   their bishops and leaders, made this trial possible. Data were collected
   and organized by Crystal MacAllum, Gail Thomas, Ed Mann, and their team
   at Westat, as well as Amanda Wallace and Alana Bennett. Thirteen
   Wellness Advocates implemented the intervention with great care. Amanda
   Wallace and Adeola Awodele helped prepare the manuscript. This trial was
   funded by the Rural Church Area of The Duke Endowment,
   http://dukeendowment.org/. The Duke University Arts and Sciences IRB
   protocol number is A0208.
CR Ackermann RT, 2011, CHRONIC ILLN, V7, P279, DOI 10.1177/1742395311407532
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   [Anonymous], 2015, OCC OUTL HDB
   [Anonymous], 1998, CLIN GUID ID EV TREA
   Befort C, 2013, ANN BEHAV MED, V45, P133, DOI 10.1007/s12160-012-9445-7
   Bishop GD, 2005, AM HEART J, V150, P602, DOI 10.1016/j.ahj.2004.10.015
   BLACKBURN G, 1995, OBES RES, V3, pS211, DOI 10.1002/j.1550-8528.1995.tb00466.x
   Blouin R., 2015, Research in the Social Scientific Study of Religion, V26, P141, DOI [DOI 10.1163/9789004299436_010, 10.1163/ 9789004299436_010]
   Butryn ML, 2011, PSYCHIAT CLIN N AM, V34, P841, DOI 10.1016/j.psc.2011.08.006
   Cox TL, 2013, HEALTH EDUC BEHAV, V40, P78, DOI 10.1177/1090198112439411
   Curioni CC, 2005, INT J OBESITY, V29, P1168, DOI 10.1038/sj.ijo.0803015
   Dallman MF, 2005, BRAIN BEHAV IMMUN, V19, P275, DOI 10.1016/j.bbi.2004.11.004
   Dansinger ML, 2007, ANN INTERN MED, V147, P41, DOI 10.7326/0003-4819-147-1-200707030-00007
   Daubenmier J, 2011, J OBES, V2011, DOI 10.1155/2011/651936
   DPP Res Grp, 2002, DIABETES CARE, V25, P2165
   Franz MJ, 2007, J AM DIET ASSOC, V107, P1755, DOI 10.1016/j.jada.2007.07.017
   Frenk SM, 2013, J RELIG HEALTH, V52, P397, DOI 10.1007/s10943-011-9486-4
   FRISON L, 1992, STAT MED, V11, P1685, DOI 10.1002/sim.4780111304
   General Board of Pensions and Health Benefits of the United Methodist Church, 2013, ANN CLERG HLTH SURV
   Handley MA, 2011, J AM BOARD FAM MED, V24, P589, DOI 10.3122/jabfm.2011.05.110067
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jeffery RW, 2000, HEALTH PSYCHOL, V19, P5, DOI 10.1037/0278-6133.19.Suppl1.5
   Jensen MD, 2014, J AM COLL CARDIOL, V63, P2985, DOI 10.1016/j.jacc.2013.11.004
   Jolani S, 2014, J BIOM BIOSTAT, V5, P194
   Knox S, 2005, PASTOR PSYCHOL, V54, P139, DOI 10.1007/s11089-005-6199-1
   Koppenaal T, 2011, J CLIN EPIDEMIOL, V64, P1095, DOI 10.1016/j.jclinepi.2010.11.020
   Kroenke K, 2009, J AFFECT DISORDERS, V114, P163, DOI 10.1016/j.jad.2008.06.026
   Lee C, 2003, FAM RELAT, V52, P249, DOI 10.1111/j.1741-3729.2003.00249.x
   Little RJ, 2019, STAT ANAL MISSING DA, V793
   Lorenzo C, 2003, DIABETES CARE, V26, P3153, DOI 10.2337/diacare.26.11.3153
   Morris M.L., 1998, J CHILD FAM STUD, V7, P27, DOI [DOI 10.1023/A:1022955912433, 10.1023/A:1022955912433]
   Ogden Cynthia L, 2012, NCHS Data Brief, P1
   Proeschold-Bell RJ, 2013, J PRIM PREV, V34, P439, DOI 10.1007/s10935-013-0321-4
   Proeschold-Bell RJ, 2013, CONTEMP CLIN TRIALS, V35, P138, DOI 10.1016/j.cct.2013.05.005
   Proeschold-Bell RJ, 2011, J RELIG HEALTH, V50, P700, DOI 10.1007/s10943-009-9250-1
   Proeschold-Bell RJ, 2010, OBESITY, V18, P1867, DOI 10.1038/oby.2010.102
   Spitzer RL, 1999, JAMA-J AM MED ASSOC, V282, P1737, DOI 10.1001/jama.282.18.1737
   The General Council on Finance and Administration of the United Methodist Church, 2012, STAT FEM RAC ETHN UN
   Thorpe KE, 2009, J CLIN EPIDEMIOL, V62, P464, DOI [10.1503/cmaj.090523, 10.1016/j.jclinepi.2008.12.011]
   Van Gaal LF, 2005, EUR HEART J SUPPL, V7, pL21, DOI 10.1093/eurheartj/sui082
   Williams R.B., 2006, CONTROL NO MORE SNAP
   Williams VP, 2010, PSYCHOSOM MED, V72, P897, DOI 10.1097/PSY.0b013e3181fc2d09
   Wing RR, 2011, DIABETES CARE, V34, P1481, DOI 10.2337/dc10-2415
   Yelland LN, 2011, AM J EPIDEMIOL, V174, P984, DOI 10.1093/aje/kwr183
   ZEGER SL, 1988, BIOMETRICS, V44, P1049, DOI 10.2307/2531734
NR 45
TC 22
Z9 25
U1 0
U2 18
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0749-3797
EI 1873-2607
J9 AM J PREV MED
JI Am. J. Prev. Med.
PD SEP
PY 2017
VL 53
IS 3
BP 290
EP 299
DI 10.1016/j.amepre.2017.04.009
PG 10
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA FE0QI
UT WOS:000407924400011
PM 28641912
DA 2025-06-11
ER

PT J
AU Agarwal, A
   Agarwal, M
   Garg, K
   Dalal, PK
   Trivedi, JK
   Srivastava, JS
AF Agarwal, Anju
   Agarwal, Manu
   Garg, Kabir
   Dalal, Pronob Kumar
   Trivedi, Jitendra Kumar
   Srivastava, J. S.
TI Metabolic syndrome and central obesity in depression: A cross-sectional
   study
SO INDIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Central obesity; depression; metabolic syndrome; obesity
ID 3RD NATIONAL-HEALTH; MAJOR DEPRESSION; GENERAL-POPULATION; ABDOMINAL
   OBESITY; BIPOLAR DISORDER; YOUNG-ADULTS; PREVALENCE; SCHIZOPHRENIA;
   SYMPTOMS; METAANALYSIS
AB Introduction: The current epidemiological data and meta-analyses indicate a bidirectional association between depression and metabolic syndrome (MetS).
   Aims: To assess the prevalence of metabolic syndrome and obesity in drug naive patients (in current episode) having Recurrent Major Depressive Disorder and Bipolar Depression.
   Method: This was a single point cross sectional observational study that involved administration of diagnostic and assessment tools and blood investigations. Recruitment for the study was done from a period of September 2008 to august 2009.
   Results: The prevalence of MetS was significantly more in the depression group when compared to healthy controls. The Bipolar depression group had 24% prevalence and recurrent depression group had 26% prevalence as opposed to none in the control group. The prevalence of MetS did not differ significantly amongst the both depression groups. Presence of central obesity was significantly more in the recurrent depression (30%) and Bipolar depression (24%) as compared to controls (8%). There was no statistically significant difference between the two depression subgroups.
   Discussion: Our study adds to the mounting evidence that links the presence of depression and metabolic syndrome. As we had ensured a drug free period of at least 3 months, the findings in our study indicate that the metabolic syndrome observed in our study is independent of drug exposure.
   Conclusions: This study demonstrated significantly more incidence of metabolic syndrome and central obesity in patients of depression than age and sex matched controls.
C1 [Agarwal, Anju] Eras Lucknow Med Coll, Dept Psychiat, Lucknow, Uttar Pradesh, India.
   [Agarwal, Manu; Garg, Kabir; Dalal, Pronob Kumar; Trivedi, Jitendra Kumar] King Georges Med Univ, Dept Psychiat, Lucknow 226003, Uttar Pradesh, India.
   [Srivastava, J. S.] Cent Drug Res Inst, Lucknow, Uttar Pradesh, India.
C3 King George's Medical University; Council of Scientific & Industrial
   Research (CSIR) - India; CSIR - Central Drug Research Institute (CDRI)
RP Garg, K (corresponding author), King Georges Med Univ, Dept Psychiat, Lucknow 226003, Uttar Pradesh, India.
EM kabirgarg@kgmcindia.edu
RI Dalal, Pronob/AAQ-2603-2020; Garg, Kabir/P-4228-2015
OI Garg, Kabir/0000-0003-1534-2129; DALAL, PRONOB KUMAR/0000-0001-7317-4480
CR Akbaraly TN, 2009, DIABETES CARE, V32, P499, DOI 10.2337/dc08-1358
   Allison DB, 1999, AM J PSYCHIAT, V156, P1686
   American Psychiatric Association, 2000, Global assessment of functioning in the diagnostic and statistical manual of mental disorders, V4th, P34
   [Anonymous], sion Scale for Schizophrenia; CGI-S, Clinical Global Impres
   [Anonymous], 2000, DIAGN STAT MAN MENT
   Atlantis E, 2008, INT J OBESITY, V32, P881, DOI 10.1038/ijo.2008.54
   Avasthi Ajit, 2010, Indian J Psychiatry, V52, pS317, DOI 10.4103/0019-5545.69261
   Blaine B, 2008, J HEALTH PSYCHOL, V13, P1190, DOI 10.1177/1359105308095977
   Blank Karen, 2010, J Clin Hypertens (Greenwich), V12, P456, DOI 10.1111/j.1751-7176.2010.00293.x
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   De Hert M, 2009, EUR PSYCHIAT, V24, P412, DOI 10.1016/j.eurpsy.2009.01.005
   De Hert MA, 2006, SCHIZOPHR RES, V83, P87, DOI 10.1016/j.schres.2005.12.855
   De Hert M, 2009, WORLD PSYCHIATRY, V8, P15
   de Wit L, 2010, PSYCHIAT RES, V178, P230, DOI 10.1016/j.psychres.2009.04.015
   Dortland AKBV, 2010, ACTA PSYCHIAT SCAND, V122, P30, DOI 10.1111/j.1600-0447.2010.01565.x
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Elmslie JL, 2000, J CLIN PSYCHIAT, V61, P179, DOI 10.4088/JCP.v61n0306
   First MB., 2002, STRUCTURED CLIN INTE
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   García-Toro M, 2016, J AFFECT DISORDERS, V194, P105, DOI 10.1016/j.jad.2015.12.064
   Gautam Shiv, 2011, Indian J Psychiatry, V53, P128, DOI 10.4103/0019-5545.82537
   Gaysina D, 2011, BRAIN BEHAV IMMUN, V25, P750, DOI 10.1016/j.bbi.2011.01.019
   Gil Katarzyna, 2006, Kardiol Pol, V64, P464
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Grover S, 2014, INDIAN J PSYCHIAT, V56, P371, DOI 10.4103/0019-5545.146520
   Grover Sandeep, 2013, Indian J Psychol Med, V35, P167, DOI 10.4103/0253-7176.116247
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Grundy Scott M, 2004, J Am Coll Cardiol, V44, P720, DOI 10.1016/j.jacc.2004.07.001
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Gupta R, 2004, INT J CARDIOL, V97, P257, DOI 10.1016/j.ijcard.2003.11.003
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Herva A, 2006, INT J OBESITY, V30, P520, DOI 10.1038/sj.ijo.0803174
   Kahl KG, 2012, EUR ARCH PSY CLIN N, V262, P313, DOI 10.1007/s00406-011-0277-4
   Keck PE, 2003, J CLIN PSYCHIAT, V64, P1426, DOI 10.4088/JCP.v64n1205
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178, DOI 10.4088/JCP.v69n0202
   Luppino FS, 2014, GEN HOSP PSYCHIAT, V36, P509, DOI 10.1016/j.genhosppsych.2014.05.018
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Malhotra N, 2013, J AFFECT DISORDERS, V150, P653, DOI 10.1016/j.jad.2013.03.010
   Marazziti D, 2014, CNS SPECTRUMS, V19, P293, DOI 10.1017/S1092852913000667
   Mattoo SK, 2010, INDIAN J MED RES, V131, P46
   McElroy SL, 2002, J CLIN PSYCHIAT, V63, P207, DOI 10.4088/JCP.v63n0306
   McIntyre RS, 2010, CNS DRUGS, V24, P741, DOI 10.2165/11533280-000000000-00000
   McIntyre RS, 2009, CURR DIABETES REP, V9, P51, DOI 10.1007/s11892-009-0010-0
   Misra A, 2009, J Assoc Physicians India, V57, P163
   North BJ, 2012, CIRC RES, V110, P1097, DOI 10.1161/CIRCRESAHA.111.246876
   Onyike CU, 2003, AM J EPIDEMIOL, V158, P1139, DOI 10.1093/aje/kwg275
   Patten SB, 2009, GEN HOSP PSYCHIAT, V31, P571, DOI 10.1016/j.genhosppsych.2009.08.001
   Pine DS, 1997, AM J PUBLIC HEALTH, V87, P1303, DOI 10.2105/AJPH.87.8.1303
   Pulkki-Råback L, 2009, HEALTH PSYCHOL, V28, P108, DOI 10.1037/a0012646
   Ramachandran A, 2003, DIABETES RES CLIN PR, V60, P199, DOI 10.1016/S0168-8227(03)00060-3
   Richter N, 2010, EUR ARCH PSY CLIN N, V260, P41, DOI 10.1007/s00406-009-0013-5
   Roberts RE, 2003, INT J OBESITY, V27, P514, DOI 10.1038/sj.ijo.0802204
   Roberts RE, 2002, ANN BEHAV MED, V24, P169, DOI 10.1207/S15324796ABM2403_02
   Scott KM, 2008, INT J OBESITY, V32, P192, DOI 10.1038/sj.ijo.0803701
   Takeuchi T, 2009, DIABETES METAB, V35, P32, DOI 10.1016/j.diabet.2008.06.006
   Theisen FM, 2001, J PSYCHIATR RES, V35, P339, DOI 10.1016/S0022-3956(01)00041-3
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Xu QY, 2011, OBES RES CLIN PRACT, V5, pE267, DOI 10.1016/j.orcp.2011.04.007
NR 63
TC 20
Z9 22
U1 1
U2 9
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0019-5545
EI 1998-3794
J9 INDIAN J PSYCHIAT
JI Indian J. Psychiatry
PD JUL-SEP
PY 2016
VL 58
IS 3
BP 281
EP 286
DI 10.4103/0019-5545.192021
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EB8QK
UT WOS:000387655700008
PM 28066005
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Andersson, P
   von Schreeb, A
   Johansson, L
   Sturidsson, K
   Wetterborg, D
   Sorjonen, K
AF Andersson, Peter
   von Schreeb, Agnes
   Johansson, Linnea
   Sturidsson, Knut
   Wetterborg, Dan
   Sorjonen, Kimmo
TI Changes in Body Mass Index During Mandatory Forensic Psychiatric Care:
   Findings from a Long-Term (2009-2020) Cohort Study Based on Swedish
   Registry Data
SO INTERNATIONAL JOURNAL OF FORENSIC MENTAL HEALTH
LA English
DT Article
DE Metabolic syndrome (MetS); premature mortality; forensic mental health;
   somatic co-morbidity
ID WEIGHT-GAIN; MORTALITY GAP; SCHIZOPHRENIA; HEALTH; DISORDERS; RISK
AB Lifespan is reduced by approximately 15 years in individuals suffering from severe mental illnesses such as schizophrenia spectrum disorders. Contributing to this is an increased prevalence of metabolic syndrome, an assortment of factors that confer risk of diabetes type 2 and cardiovascular disease. Body Mass Index (BMI) is predictive of metabolic syndrome. Previous research indicates that the BMI of incarcerated individuals not suffering from a major mental disorder increase during incarceration, especially amongst females. However, information on the development of BMI during forensic psychiatric care is scarcer, and follow-up periods have been short. Thus, the authors extracted data from the Swedish National Forensic Psychiatric Register regarding the longitudinal development of BMI in 3389 individuals who received court mandated forensic psychiatric care in Sweden during 2009-2020. A significant increase in BMI by 1.1% per year was observed during the first four years of care. After this, changes were no longer significant. Factors associated with a larger increase in BMI were female gender, being prescribed antipsychotics, young age at admission, receiving outpatient care, and access to an external support person. There was an inverse association between BMI and symptom severity. Substantial heterogeneity was observed in longitudinal changes in individual BMI and in comparisons between individuals receiving care at different clinics.
C1 [Andersson, Peter; von Schreeb, Agnes; Johansson, Linnea; Sturidsson, Knut; Wetterborg, Dan; Sorjonen, Kimmo] Karolinska Inst, Dept Clin Neurosci, Div Psychol, S-17165 Stockholm, Sweden.
   [Andersson, Peter] Uppsala Univ, Ctr Clin Res Dalarna, Falun, Sweden.
C3 Karolinska Institutet; Uppsala University
RP Andersson, P (corresponding author), Karolinska Inst, Dept Clin Neurosci, Div Psychol, S-17165 Stockholm, Sweden.
EM peter.andersson@ki.se
OI Sturidsson, Knut/0000-0002-4130-2270; Andersson,
   Peter/0000-0002-1358-2463; Wetterborg, Dan/0000-0003-0833-0525
CR Andiné P, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00840
   Andreasson H, 2014, INT J LAW PSYCHIAT, V37, P635, DOI 10.1016/j.ijlp.2014.02.038
   [Anonymous], 2010, International Journal of Forensic Mental Health
   Bojanowski M., 2017, lspline: linear splines with convenient parametrisations (1.0-0) Computer software
   Bondolfi C, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2020-039278
   Bonfioli E, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-78
   Chen C, 2019, BMJ-BRIT MED J, V367, DOI 10.1136/bmj.l5584
   Dornquast C, 2017, BMC HEALTH SERV RES, V17, DOI 10.1186/s12913-017-2106-6
   Duke LH, 2018, SOC PSYCH PSYCH EPID, V53, P313, DOI 10.1007/s00127-017-1473-y
   Epperson MW, 2014, INT J LAW PSYCHIAT, V37, P427, DOI 10.1016/j.ijlp.2014.02.015
   Fernández-Abascal B, 2021, NEUROSCI BIOBEHAV R, V125, P535, DOI 10.1016/j.neubiorev.2021.01.005
   Gaab S, 2020, INT J OFFENDER THER, V64, P1013, DOI 10.1177/0306624X19899609
   Gebremariam MK, 2018, OBES REV, V19, P98, DOI 10.1111/obr.12622
   Guy W., 1976, ECDEU Assessment Manual for Psychopharmacology, Revised. US Department of Health, Education, and Welfare Publication (ADM), P76
   Hayes JF, 2017, BRIT J PSYCHIAT, V211, P175, DOI 10.1192/bjp.bp.117.202606
   Herbert K, 2012, LANCET, V379, P1975, DOI 10.1016/S0140-6736(12)60319-5
   Hilton NZ, 2022, INT J FORENSIC MENT, V21, P164, DOI 10.1080/14999013.2021.1952356
   Hilton NZ, 2015, CAN J PSYCHIAT, V60, P232, DOI 10.1177/070674371506000505
   Hjorthoj C, 2017, LANCET PSYCHIAT, V4, P295, DOI 10.1016/S2215-0366(17)30078-0
   Hunt Hazel J, 2021, J Clin Psychopharmacol, V41, P632, DOI 10.1097/JCP.0000000000001470
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Krishnamoorthy Y, 2022, PREV CHRONIC DIS, V19, DOI 10.5888/pcd19.210231
   Kuznetsova A, 2017, J STAT SOFTW, V82, P1, DOI 10.18637/jss.v082.i13
   Laursen TM, 2014, ANNU REV CLIN PSYCHO, V10, P425, DOI 10.1146/annurev-clinpsy-032813-153657
   Lessons GR, 2022, INT ARCH OCC ENV HEA, V95, P779, DOI 10.1007/s00420-021-01761-4
   Long C, 2014, MENT HEALTH REV J, V19, P37, DOI 10.1108/MHRJ-04-2013-0012
   Ma T, 2021, J FORENSIC PSYCHI PS, V32, P281, DOI 10.1080/14789949.2020.1859588
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Moss K, 2022, INT J FORENSIC MENT, V21, P194, DOI 10.1080/14999013.2021.1943570
   Nielsen RE, 2013, SCHIZOPHR RES, V146, P22, DOI 10.1016/j.schres.2013.02.025
   Nyman M, 2022, ISSUES MENT HEALTH N, V43, P137, DOI 10.1080/01612840.2021.1956658
   Public Health Agency of Sweden, 2022, OV FETM HOS VUXN
   R Core Team, 2022, R: A Language and Environment for Statistical Computing
   Sagud M, 2019, CURR OPIN PSYCHIATR, V32, P402, DOI 10.1097/YCO.0000000000000529
   SBU, 2018, PSYK BEH PSYK INS RA
   SBU, 2018, 286 SBU
   Senneseth M, 2021, BJPSYCH OPEN, V8, DOI 10.1192/bjo.2021.1068
   Söderberg A, 2022, ISSUES MENT HEALTH N, V43, P683, DOI 10.1080/01612840.2022.2033894
   Sturidsson K., 2007, INT J FORENSIC MENT, V6, P79, DOI [10.1080/14999013.2007.10471251, DOI 10.1080/14999013.2007.10471251]
   Swedish National Forensic Psychiatric Register RattspsyK, 2021, ANN REP 2021
   Swildens W, 2016, ADM POLICY MENT HLTH, V43, P650, DOI 10.1007/s10488-015-0679-0
   Tiihonen J, 2009, LANCET, V374, P620, DOI 10.1016/S0140-6736(09)60742-X
   Vasic N, 2018, J FORENSIC PSYCHI PS, V29, P1, DOI 10.1080/14789949.2017.1332773
   Walker ER, 2015, JAMA PSYCHIAT, V72, P334, DOI 10.1001/jamapsychiatry.2014.2502
   Whitaker R, 2020, PSYCHOL MED, V50, P2643, DOI 10.1017/S003329172000358X
   Wickham H., 2022, Stringr: Simple, Consistent Wrappers for Common String Operations
   World Health Organization, 2021, CARD DIS CVDS FACTSH
   Zheng W, 2015, J CLIN PSYCHOPHARM, V35, P499, DOI 10.1097/JCP.0000000000000392
NR 48
TC 1
Z9 1
U1 0
U2 4
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1499-9013
EI 1932-9903
J9 INT J FORENSIC MENT
JI Int. J. Forensic Ment. Health
PD APR 2
PY 2024
VL 23
IS 2
BP 106
EP 116
DI 10.1080/14999013.2023.2214381
EA MAY 2023
PG 11
WC Criminology & Penology; Psychiatry
WE Social Science Citation Index (SSCI)
SC Criminology & Penology; Psychiatry
GA PO0V7
UT WOS:000993580400001
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Liu, Y
   Ettinger, AS
   Téllez-Rojo, M
   Sánchez, BN
   Zhang, ZZ
   Cantoral, A
   Hu, H
   Peterson, KE
AF Liu, Yun
   Ettinger, Adrienne S.
   Tellez-Rojo, Martha
   Sanchez, Brisa N.
   Zhang, Zhenzhen
   Cantoral, Alejandra
   Hu, Howard
   Peterson, Karen E.
TI Prenatal Lead Exposure, Type 2 Diabetes, and Cardiometabolic Risk
   Factors in Mexican Children at Age 10-18 Years
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE blood lead; children; type 2 diabetes; cardiometabolic risk;
   cholesterols
ID METABOLIC SYNDROME; OXIDATIVE STRESS; INSULIN SENSITIVITY;
   CARDIOVASCULAR RISK; NATIONAL-HEALTH; ASSOCIATION; PREGNANCY; PLASMA;
   BLOOD; CHOLESTEROL
AB Context: Several cross-sectional studies have assessed the association of lead exposure with type 2 diabetes and cardiometabolic risk factors in adults; however, studies of such associations in childhood are rare.
   Objective: We assessed the prospective associations of prenatal exposure to lead with type 2 diabetes and cardiometabolic risk factors in children.
   Design: The Early Life Exposure in Mexico to Environmental Toxicants is a birth cohort study of pregnant women and their offspring.
   Setting: Public hospitals in Mexico City.
   Patients or Other Participants: Women were recruited during pregnancy; their offspring were recruited for a follow-up visit at age 10 to 18 years (n = 369).
   Main Outcome Measures: We measured fasting serum markers of type 2 diabetes and cardiometabolic risk factors in children, including fasting glucose, insulin, and lipids. The index of insulin resistance was calculated.
   Results: The geometric mean of maternal blood lead levels (BLLs) during pregnancy was 4.3 mu g/dL (95% confidence interval [CI]): 4.0-4.6 mu g/dL) in the entire sample. In boys, those with maternal BLLs = 5 mu g/dL (compared with those with BLLs < 5 mu g/dL) had significantly lower z scores for total cholesterol (beta = -0.41, 95% CI: -0.71, -0.12), high-density lipoprotein cholesterol (beta = -0.32, 95% CI: -0.59, -0.05), and low-density lipoprotein cholesterol (beta = -0.52, 95% CI: -0.81, -0.22), adjusting for covariates. No associations were detected in girls.
   Conclusions: In our study, we found that higher prenatal exposure to lead was associated with lower levels of cholesterol in children following a sex-specific pattern. Further studies with a larger sample size that examine whether sex is a potential modifier are needed to confirm our findings.
C1 [Liu, Yun; Ettinger, Adrienne S.; Peterson, Karen E.] Univ Michigan, Sch Publ Hlth, Dept Nutr Sci, 1867 SPH 1,1415 Washington Hts, Ann Arbor, MI 48109 USA.
   [Tellez-Rojo, Martha; Cantoral, Alejandra] Natl Inst Publ Hlth, Nutr & Hlth Res Ctr, Cuernavaca 62100, Morelos, Mexico.
   [Sanchez, Brisa N.; Zhang, Zhenzhen] Univ Michigan, Dept Biostat, Sch Publ Hlth, Ann Arbor, MI 48109 USA.
   [Hu, Howard] Univ Washington, Dept Environm & Occupat Hlth Sci, Sch Publ Hlth, Seattle, WA 98195 USA.
   [Hu, Howard; Peterson, Karen E.] Univ Michigan, Dept Environm Hlth Sci, Sch Publ Hlth, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; Instituto
   Nacional de Salud Publica; University of Michigan System; University of
   Michigan; University of Washington; University of Washington Seattle;
   University of Michigan System; University of Michigan
RP Peterson, KE (corresponding author), Univ Michigan, Sch Publ Hlth, Dept Nutr Sci, 1867 SPH 1,1415 Washington Hts, Ann Arbor, MI 48109 USA.
EM karenep@umich.edu
RI Hu, Howard/AAV-5360-2021; Cantoral, Alejandra/AAA-3615-2021; Ettinger,
   Adrienne/ABF-6655-2020
OI Sanchez, Brisa/0000-0002-4824-7200; Tellez Rojo,
   Martha/0000-0003-3322-3334; Hu, Howard/0000-0002-3676-2707; Ettinger,
   Adrienne S./0000-0002-0200-8677
FU U.S. National Institutes of Health [R01ES021446, R01ES007821]; National
   Institute of Environmental Health Sciences/the U.S. Environmental
   Protection Agency [P01ES022844]; National Institute of Environmental
   Health Sciences [P20ES018171]; National Institute of Public
   Health/Ministry of Health of Mexico; National Institute of Diabetes and
   Digestive and Kidney Diseases [P30DK020572]; National Institute of
   Diabetes and Digestive and Kidney Diseases [P30DK020572] Funding Source:
   NIH RePORTER
FX The study was supported by grants R01ES021446 and R01ES007821 from the
   U.S. National Institutes of Health, grant P01ES022844 from the National
   Institute of Environmental Health Sciences/the U.S. Environmental
   Protection Agency, and grant P20ES018171 from the National Institute of
   Environmental Health Sciences. This study was also supported and
   partially funded by the National Institute of Public Health/Ministry of
   Health of Mexico and by grant P30DK020572 (Michigan Diabetes Research
   Center) from the National Institute of Diabetes and Digestive and Kidney
   Diseases.
CR Afeiche M, 2011, ENVIRON HEALTH PERSP, V119, P1436, DOI 10.1289/ehp.1003184
   Al-Hamad D, 2017, TRANSL PEDIATR, V6, P397, DOI 10.21037/tp.2017.10.02
   Andersson C, 2015, DIABETOLOGIA, V58, P2774, DOI 10.1007/s00125-015-3762-x
   [Anonymous], 2010, CHILDH LEAD POIS
   Bashash M, 2017, ENVIRON HEALTH PERSP, V125, DOI 10.1289/EHP655
   Bhatti JS, 2017, PROG MOL BIOL TRANSL, V146, P13, DOI 10.1016/bs.pmbts.2016.12.012
   Bulka CM, 2019, ENVIRON RES, V168, P397, DOI 10.1016/j.envres.2018.10.022
   Chen L, 2012, NAT REV ENDOCRINOL, V8, P228, DOI 10.1038/nrendo.2011.183
   D'Adamo E, 2011, DIABETES CARE, V34, pS161, DOI 10.2337/dc11-s212
   De Long NE, 2017, DIABET METAB SYND OB, V10, P101, DOI 10.2147/DMSO.S95296
   Ettinger AS, 2014, ENVIRON HEALTH-GLOB, V13, DOI 10.1186/1476-069X-13-90
   Ettinger AS, 2014, ENVIRON HEALTH PERSP, V122, P87, DOI 10.1289/ehp.1307187
   Ettinger AS, 2009, ENVIRON HEALTH PERSP, V117, P26, DOI [10.1289/ehp.11868, 10.1289/ehp.1171c26]
   Federacion DOdl, 2017, NIV PLOM SANGR ACC C
   Feng WQ, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0123520
   Hadjiphilippou S, 2018, CARDIOL CLIN, V36, P213, DOI 10.1016/j.ccl.2017.12.002
   HAMMOND PB, 1990, TOXICOL APPL PHARM, V106, P80, DOI 10.1016/0041-008X(90)90108-7
   Hu H, 2006, ENVIRON HEALTH PERSP, V114, P1730, DOI 10.1289/ehp.9067
   Hunt KJ, 2011, ANN EPIDEMIOL, V21, P899, DOI 10.1016/j.annepidem.2011.07.003
   Peña-Espinoza BI, 2017, ENDOCRINOL DIAB NUTR, V64, P369, DOI 10.1016/j.endinu.2017.04.004
   Jomova K, 2011, TOXICOLOGY, V283, P65, DOI 10.1016/j.tox.2011.03.001
   Juonala M, 2011, NEW ENGL J MED, V365, P1876, DOI 10.1056/NEJMoa1010112
   Kander MC, 2017, J CELL MOL MED, V21, P1024, DOI 10.1111/jcmm.13038
   KARABACAK M, 2014, INT J OFFENDER THER, V65, P927, DOI DOI 10.1177/0003319713512173
   Kim C, 2014, CURR CARDIOL REP, V16, DOI 10.1007/s11886-014-0467-6
   Kolb H, 2017, BMC MED, V15, DOI 10.1186/s12916-017-0901-x
   Kupsco A, 2019, EPIDEMIOLOGY, V30, P263, DOI [10.1097/EDE.0000000000000962, 10.1097/ede.0000000000000962]
   Leff T, 2018, TOXICS, V6, DOI 10.3390/toxics6030054
   Liu Y, 2019, ENVIRON INT, V125, P445, DOI 10.1016/j.envint.2019.02.021
   Macotela Y, 2009, DIABETES, V58, P803, DOI 10.2337/db08-1054
   Meza R, 2015, PREV MED, V81, P445, DOI 10.1016/j.ypmed.2015.10.015
   Moon SS, 2013, DIABETIC MED, V30, pe143, DOI 10.1111/dme.12103
   Oda E, 2018, OBES RES CLIN PRACT, V12, P195, DOI 10.1016/j.orcp.2017.05.005
   Paige E, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-017-0520-z
   Pantic I, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15102153
   Poursafa P, 2014, ENVIRON SCI POLLUT R, V21, P13496, DOI 10.1007/s11356-014-3238-4
   Puolakka E, 2016, DIABETES CARE, V39, P2311, DOI 10.2337/dc16-1565
   Rader DJ, 2014, LANCET, V384, P618, DOI 10.1016/S0140-6736(14)61217-4
   Reinehr T, 2013, WORLD J DIABETES, V4, P270, DOI 10.4239/wjd.v4.i6.270
   Rhee SY, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-9
   Rinaudo P, 2012, ANNU REV PHYSIOL, V74, P107, DOI 10.1146/annurev-physiol-020911-153245
   Roglic G., 2016, Rural Development Report 2016
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sardinha LB, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0149351
   Shapiro GD, 2015, ENVIRON INT, V83, P63, DOI 10.1016/j.envint.2015.05.016
   Soto-Estrada G, 2018, GAC SANIT, V32, P283, DOI 10.1016/j.gaceta.2017.08.001
   Téllez-Rojo MM, 2004, AM J EPIDEMIOL, V160, P668, DOI 10.1093/aje/kwh271
   Weiss R, 2013, ANN NY ACAD SCI, V1281, P123, DOI 10.1111/nyas.12030
   White J, 2016, JAMA CARDIOL, V1, P692, DOI 10.1001/jamacardio.2016.1884
   Widén E, 2012, DIABETES CARE, V35, P850, DOI 10.2337/dc11-1365
   Yokoyama H, 2004, J CLIN ENDOCR METAB, V89, P1481, DOI 10.1210/jc.2003-031374
   Zhan YQ, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-921
NR 52
TC 14
Z9 15
U1 0
U2 6
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JAN
PY 2020
VL 105
IS 1
BP 210
EP 218
DI 10.1210/clinem/dgz038
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA KS2XC
UT WOS:000518172400020
PM 31608940
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Schmitt, A
   Maurus, I
   Rossner, MJ
   Roh, A
   Lembeck, M
   von Wilmsdorff, M
   Takahashi, S
   Rauchmann, B
   Keeser, D
   Hasan, A
   Malchow, B
   Falkai, P
AF Schmitt, Andrea
   Maurus, Isabel
   Rossner, Moritz J.
   Roh, Astrid
   Lembeck, Moritz
   von Wilmsdorff, Martina
   Takahashi, Shun
   Rauchmann, Boris
   Keeser, Daniel
   Hasan, Alkomiet
   Malchow, Berend
   Falkai, Peter
TI Effects of Aerobic Exercise on Metabolic Syndrome, Cardiorespiratory
   Fitness, and Symptoms in Schizophrenia Include Decreased Mortality
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE aerobic exercise; endurance training; high-intensity interval training;
   metabolic syndrome; mortality; schizophrenia; cognition; positive and
   negative symptoms
ID CORONARY-HEART-DISEASE; ALL-CAUSE MORTALITY; PHYSICAL-ACTIVITY; 1ST
   EPISODE; COMPARATIVE METAANALYSIS; CARDIOMETABOLIC DISEASE;
   CARDIOVASCULAR EVENTS; ANTIPSYCHOTIC-DRUGS; PSYCHOTIC DISORDERS;
   INSULIN-RESISTANCE
AB Schizophrenia is a severe psychiatric disorder with a lifetime prevalence of about 1%. People with schizophrenia have a 4-fold higher prevalence of metabolic syndrome than the general population, mainly because of antipsychotic treatment but perhaps also because of decreased physical activity. Metabolic syndrome is a risk factor for cardiovascular diseases, and the risk of these diseases is 2- to 3-fold higher in schizophrenia patients than in the general population. The suicide risk is also higher in schizophrenia, partly as a result of depression, positive, and cognitive symptoms of the disease. The higher suicide rate and higher rate of cardiac mortality, a consequence of the increased prevalance of cardiovascular diseases, contribute to the reduced life expectancy, which is up to 20 years lower than in the general population. Regular physical activity, especially in combination with psychosocial and dietary interventions, can improve parameters of the metabolic syndrome and cardiorespiratory fitness. Furthermore, aerobic exercise has been shown to improve cognitive deficits; total symptom severity, including positive and negative symptoms; depression; quality of life; and global functioning. High-intensity interval endurance training is a feasible and effective way to improve cardiorespiratory fitness and metabolic parameters and has been established as such in somatic disorders. It may have more beneficial effects on the metabolic state than more moderate and continuous endurance training methods, but to date it has not been investigated in schizophrenia patients in controlled, randomized trials. This review discusses physical training methods to improve cardiorespiratory fitness and reduce metabolic syndrome risk factors and symptoms in schizophrenia patients. The results of studies and future high-quality clinical trials are expected to lead to the development of an evidence-based physical training program for patients that includes practical recommendations, such as the optimal length and type of aerobic exercise programs and the ideal combination of exercise, psychoeducation, and individual weight management sessions.
C1 [Schmitt, Andrea; Maurus, Isabel; Rossner, Moritz J.; Roh, Astrid; Lembeck, Moritz; Takahashi, Shun; Hasan, Alkomiet; Falkai, Peter] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany.
   [Schmitt, Andrea] Univ Sao Paulo, Inst Psychiat, Lab Neurosci LIM27, Sao Paulo, Brazil.
   [von Wilmsdorff, Martina] Heinrich Heine Univ, Med Fac, Dept Psychiat & Psychotherapy, Dusseldorf, Germany.
   [Takahashi, Shun] Wakayama Med Univ, Dept Neuropsychiat, Wakayama, Japan.
   [Rauchmann, Boris; Keeser, Daniel] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Radiol, Munich, Germany.
   [Malchow, Berend] Univ Hosp Jena, Dept Psychiat & Psychotherapy, Jena, Germany.
C3 University of Munich; Universidade de Sao Paulo; Heinrich Heine
   University Dusseldorf; Wakayama Medical University; University of
   Munich; Friedrich Schiller University of Jena
RP Schmitt, A (corresponding author), Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany.; Schmitt, A (corresponding author), Univ Sao Paulo, Inst Psychiat, Lab Neurosci LIM27, Sao Paulo, Brazil.
EM andrea.schmitt@med.uni-muenchen.de
RI Rauchmann, Boris-Stephan/GLQ-9798-2022; Malchow, Berend/AAM-9172-2020;
   Maurus, Isabel/HMO-5534-2023; Takahashi, Shun/AIF-1768-2022; Falkai,
   Peter/E-3273-2017; Keeser, Daniel/C-8888-2016
OI Falkai, Peter/0000-0003-2873-8667; Keeser, Daniel/0000-0002-0244-1024
FU Deutsche Forschungsgemeinschaft (DFG): Klinische Forschergruppe (KFO)
   241 and PsyCourse [FA241/16-1]; German Federal Ministry of Education and
   Research (BMBF) through the research network on psychiatric diseases
   ESPRIT [01EE1407E]
FX This research was funded by the following grants from the Deutsche
   Forschungsgemeinschaft (DFG): Klinische Forschergruppe (KFO) 241 and
   PsyCourse to PF (FA241/16-1). Further funding was received from the
   German Federal Ministry of Education and Research (BMBF) through the
   research network on psychiatric diseases ESPRIT (grant number 01EE1407E)
   to PF, AH, and AS.
CR Abdel-Baki A, 2013, SCHIZOPHR RES, V149, P112, DOI 10.1016/j.schres.2013.06.040
   Agelink MW, 2001, J CLIN PSYCHOPHARM, V21, P8, DOI 10.1097/00004714-200102000-00003
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Amiaz R, 2016, PHARMACOPSYCHIATRY, V49, P112, DOI 10.1055/s-0035-1569416
   an der Heiden W., 2011, Schizophrenia, V3rd, P104
   [Anonymous], 2018, DTSCH GESELLSCHAFT P
   [Anonymous], SCHIZOPHRENIA BULL
   Armstrong HF, 2016, SCHIZOPHR RES, V173, P116, DOI 10.1016/j.schres.2016.03.009
   Arnsten AFT, 2009, NAT REV NEUROSCI, V10, P410, DOI 10.1038/nrn2648
   Bär KJ, 2015, FRONT NEUROL, V6, DOI 10.3389/fneur.2015.00139
   Ball MP, 2001, PSYCHIATR SERV, V52, P967, DOI 10.1176/appi.ps.52.7.967
   Barry VW, 2014, PROG CARDIOVASC DIS, V56, P382, DOI 10.1016/j.pcad.2013.09.002
   Batacan RB Jr, 2017, BRIT J SPORT MED, V51, DOI 10.1136/bjsports-2015-095841
   Berryman N, 2014, AGE, V36, DOI 10.1007/s11357-014-9710-8
   Bora E, 2017, PSYCHOL MED, V47, P1030, DOI 10.1017/S0033291716003366
   Bornheimer LA, 2019, SUICIDE LIFE-THREAT, V49, P423, DOI 10.1111/sltb.12440
   Bredin SSD, 2013, BRAIN SCI, V3, P821, DOI 10.3390/brainsci3020821
   Callaghan P, 2004, J Psychiatr Ment Health Nurs, V11, P476, DOI 10.1111/j.1365-2850.2004.00751.x
   Canal-Rivero M, 2018, EUR PSYCHIAT, V53, P52, DOI 10.1016/j.eurpsy.2018.06.001
   Cassidy RM, 2018, SCHIZOPHRENIA BULL, V44, P787, DOI 10.1093/schbul/sbx131
   Chekroud SR, 2018, LANCET PSYCHIAT, V5, P739, DOI 10.1016/S2215-0366(18)30227-X
   Clapham E, 2019, SUICIDE LIFE-THREAT, V49, P996, DOI 10.1111/sltb.12499
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Correll CU, 2006, J CLIN PSYCHIAT, V67, P575, DOI 10.4088/JCP.v67n0408
   Daumit GL, 2013, NEW ENGL J MED, V368, P1594, DOI 10.1056/NEJMoa1214530
   De Hert M, 2018, DIALOGUES CLIN NEURO, V20, P31, DOI 10.31887/DCNS.2018.20.1/mdehert
   De Strijcker D, 2018, J MUSCULOSKEL NEURON, V18, P215
   Dodd KJ, 2011, DISABIL REHABIL, V33, P1222, DOI 10.3109/09638288.2010.526162
   Drigny J, 2014, J REHABIL MED, V46, P1050, DOI 10.2340/16501977-1905
   Ellis N, 2007, BRIT J CLIN PSYCHOL, V46, P95, DOI 10.1348/014466506X122995
   Ellison-Wright I, 2009, SCHIZOPHR RES, V108, P3, DOI 10.1016/j.schres.2008.11.021
   Erickson KI, 2011, P NATL ACAD SCI USA, V108, P3017, DOI 10.1073/pnas.1015950108
   Falkai P, 2015, MOL PSYCHIATR, V20, P671, DOI 10.1038/mp.2015.35
   Falkai P, 2016, SCHIZOPHRENIA BULL, V42, pS4, DOI 10.1093/schbul/sbv157
   Firth J, 2015, PSYCHOL MED, V45, P1343, DOI 10.1017/S0033291714003110
   Firth J, 2018, EARLY INTERV PSYCHIA, V12, P307, DOI 10.1111/eip.12329
   Firth J, 2017, SCHIZOPHRENIA BULL, V43, P546, DOI 10.1093/schbul/sbw115
   Foguet-Boreu Q, 2016, BMC PSYCHIATRY, V16, DOI 10.1186/s12888-016-0833-6
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Garber CE, 2011, MED SCI SPORT EXER, V43, P1334, DOI 10.1249/MSS.0b013e318213fefb
   Green MF, 1996, AM J PSYCHIAT, V153, P321
   Green MF, 2015, NAT REV NEUROSCI, V16, P620, DOI 10.1038/nrn4005
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Gurusamy J, 2018, ASIAN J PSYCHIATR, V36, P73, DOI 10.1016/j.ajp.2018.06.018
   Gustavsson A, 2011, EUR NEUROPSYCHOPHARM, V21, P718, DOI 10.1016/j.euroneuro.2011.08.008
   Haijma SV, 2013, SCHIZOPHRENIA BULL, V39, P1129, DOI 10.1093/schbul/sbs118
   Hällgren J, 2019, SCAND J PUBLIC HEALT, V47, P121, DOI 10.1177/1403494818758912
   Hanley AJG, 2005, CIRCULATION, V112, P3713, DOI 10.1161/CIRCULATIONAHA.105.559633
   Hasan A, 2012, WORLD J BIOL PSYCHIA, V13, P318, DOI 10.3109/15622975.2012.696143
   Hayes RD, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0044613
   Heald A, 2017, ANN GEN PSYCHIATR, V16, DOI 10.1186/s12991-017-0134-6
   Heggelund J, 2014, FRONT PSYCHIATRY, V5, DOI 10.3389/fpsyt.2014.00148
   Heggelund J, 2011, NORD J PSYCHIAT, V65, P269, DOI 10.3109/08039488.2011.560278
   Heinrichs RW, 1998, NEUROPSYCHOLOGY, V12, P426, DOI 10.1037/0894-4105.12.3.426
   Herbsleb M, 2014, FRONT PSYCHIATRY, V5, DOI 10.3389/fpsyt.2014.00119
   Hoff AL, 2005, SCHIZOPHR RES, V78, P27, DOI 10.1016/j.schres.2005.05.010
   JABLENSKY A, 1995, EPIDEMIOL REV, V17, P10, DOI 10.1093/oxfordjournals.epirev.a036164
   Jelleyman C, 2015, OBES REV, V16, P942, DOI 10.1111/obr.12317
   Jerome GJ, 2017, PSYCHIAT RES, V256, P85, DOI 10.1016/j.psychres.2017.06.019
   Jirsaraie RJ, 2018, SCHIZOPHR RES, V201, P237, DOI 10.1016/j.schres.2018.06.017
   Judd LL, 2005, ARCH GEN PSYCHIAT, V62, P1322, DOI 10.1001/archpsyc.62.12.1322
   Jurio-Iriarte B, 2019, HEALTH PROMOT PRACT, V20, P390, DOI 10.1177/1524839918774310
   Keating SE, 2017, OBES REV, V18, P943, DOI 10.1111/obr.12536
   Keller-Varady K, 2016, EUR ARCH PSY CLIN N, V266, P461, DOI 10.1007/s00406-015-0651-8
   Kessler HS, 2012, SPORTS MED, V42, P489, DOI 10.2165/11630910-000000000-00000
   Kodama S, 2009, JAMA-J AM MED ASSOC, V301, P2024, DOI 10.1001/jama.2009.681
   Krogh J, 2014, FRONT PSYCHIATRY, V5, DOI 10.3389/fpsyt.2014.00089
   Kuo FC, 2013, PSYCHIAT RES, V209, P150, DOI 10.1016/j.psychres.2012.11.020
   Laursen TM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024597
   Lawrence D, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f2539
   Leal J, 2006, EUR HEART J, V27, P1610, DOI 10.1093/eurheartj/ehi733
   Lee IM, 2012, LANCET, V380, P219, DOI 10.1016/S0140-6736(12)61031-9
   Leucht S, 2013, LANCET, V382, P951, DOI 10.1016/S0140-6736(13)60733-3
   Leucht S, 2009, AM J PSYCHIAT, V166, P152, DOI 10.1176/appi.ajp.2008.08030368
   Ma XJ, 2014, INT J PSYCHIAT CLIN, V18, P229, DOI 10.3109/13651501.2014.957705
   Maillard F, 2018, SPORTS MED, V48, P269, DOI 10.1007/s40279-017-0807-y
   Malchow B, 2016, SCHIZOPHR RES, V173, P182, DOI 10.1016/j.schres.2015.01.005
   Malchow B, 2015, SCHIZOPHRENIA BULL, V41, P847, DOI 10.1093/schbul/sbv020
   Malchow B, 2013, EUR ARCH PSY CLIN N, V263, P451, DOI 10.1007/s00406-013-0423-2
   Methapatara W, 2011, PSYCHIAT CLIN NEUROS, V65, P374, DOI 10.1111/j.1440-1819.2011.02225.x
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P295, DOI 10.1093/schbul/sbs082
   Murray CJL, 1996, SCIENCE, V274, P740, DOI 10.1126/science.274.5288.740
   Myers J, 2015, PROG CARDIOVASC DIS, V57, P306, DOI 10.1016/j.pcad.2014.09.011
   NICE, 2014, Psychosis and Schizophrenia in Adults: Prevention and Management (Clinical Guideline 178)
   Nyboe L, 2015, SCHIZOPHR RES, V168, P381, DOI 10.1016/j.schres.2015.07.053
   Ohi K, 2019, EUR ARCH PSY CLIN N, V269, P517, DOI 10.1007/s00406-018-0903-5
   Pajonk FG, 2010, ARCH GEN PSYCHIAT, V67, P133, DOI 10.1001/archgenpsychiatry.2009.193
   Papiol S, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/tp.2017.131
   Pearsall R, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/1471-244X-14-117
   Penzes P, 2011, NAT NEUROSCI, V14, P285, DOI 10.1038/nn.2741
   Perälä J, 2007, ARCH GEN PSYCHIAT, V64, P19, DOI 10.1001/archpsyc.64.1.19
   Oliveira BRR, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0197124
   Ray WA, 2009, NEW ENGL J MED, V360, P225, DOI 10.1056/NEJMoa0806994
   Ringen PA, 2014, FRONT PSYCHIATRY, V5, DOI 10.3389/fpsyt.2014.00137
   Roy M, 2018, MED SCI SPORT EXER, V50, P1818, DOI 10.1249/MSS.0000000000001642
   Scheewe TW, 2013, ACTA PSYCHIAT SCAND, V127, P464, DOI 10.1111/acps.12029
   Scheewe TW, 2013, EUR NEUROPSYCHOPHARM, V23, P675, DOI 10.1016/j.euroneuro.2012.08.008
   Scheewe TW, 2012, MED SCI SPORT EXER, V44, P1834, DOI 10.1249/MSS.0b013e318258e120
   Schmitt A, 2014, FRONT NEUROSCI-SWITZ, V8, DOI 10.3389/fnins.2014.00019
   Schmitt A, 2009, ACTA NEUROPATHOL, V117, P395, DOI 10.1007/s00401-008-0430-y
   Sicras-Mainar A, 2015, NEUROPSYCH DIS TREAT, V11, P51, DOI 10.2147/NDT.S75449
   Simon GE, 2018, JAMA PSYCHIAT, V75, P254, DOI 10.1001/jamapsychiatry.2017.4437
   Soundy A, 2014, J MENT HEALTH, V23, P256, DOI 10.3109/09638237.2014.951481
   Spangaro M, 2018, PSYCHONEUROENDOCRINO, V97, P135, DOI 10.1016/j.psyneuen.2018.07.017
   Stubbs B, 2016, SCHIZOPHR RES, V176, P431, DOI 10.1016/j.schres.2016.05.017
   Stubbs B, 2016, SCHIZOPHR RES, V171, P103, DOI 10.1016/j.schres.2016.01.034
   Thivel D, 2019, J SPORT MED PHYS FIT, V59, P310, DOI [10.23736/S0022-4707.18.08075-1, 10.23736/s0022-4707.18.08075-1]
   van Erp TGM, 2016, MOL PSYCHIATR, V21, P547, DOI 10.1038/mp.2015.63
   Vancampfort D, 2012, ACTA PSYCHIAT SCAND, V125, P382, DOI 10.1111/j.1600-0447.2011.01825.x
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vancampfort D, 2015, J NERV MENT DIS, V203, P23, DOI 10.1097/NMD.0000000000000229
   Vancampfort D, 2015, COMPR PSYCHIAT, V56, P128, DOI 10.1016/j.comppsych.2014.10.007
   Vancampfort D, 2013, PSYCHIAT RES, V207, P25, DOI 10.1016/j.psychres.2012.09.026
   Vancampfort D, 2012, PSYCHIAT RES, V200, P73, DOI 10.1016/j.psychres.2012.03.046
   Vissers D, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0056415
   Voineskos AN, 2013, CEREB CORTEX, V23, P2044, DOI 10.1093/cercor/bhs188
   Walker ER, 2015, JAMA PSYCHIAT, V72, P334, DOI 10.1001/jamapsychiatry.2014.2502
   Wang JJ, 2012, SCHIZOPHR RES, V140, P260, DOI 10.1016/j.schres.2012.05.008
   Weinberger DR, 1996, NEUROPSYCHOPHARMACOL, V14, pS1, DOI 10.1016/0893-133X(95)00199-N
   Weston KS, 2014, BRIT J SPORT MED, V48, P1227, DOI 10.1136/bjsports-2013-092576
   Wewege M, 2017, OBES REV, V18, P635, DOI 10.1111/obr.12532
   Wu MH, 2015, NEUROPSYCH DIS TREAT, V11, P1255, DOI 10.2147/NDT.S81482
   Zhang XY, 2018, J CLIN PSYCHIAT, V79, DOI 10.4088/JCP.17m11797
   ,, 2018, Lancet (British edition), V392, P1789, DOI 10.1016/s0140-6736(18)32279-7
NR 125
TC 56
Z9 59
U1 2
U2 40
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD DEC 21
PY 2018
VL 9
AR 690
DI 10.3389/fpsyt.2018.00690
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HF2QE
UT WOS:000454080700001
PM 30622486
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Matic, TB
   Toncev, G
   Gavrilovic, A
   Aleksic, D
AF Matic, Tatjana Boskovic
   Toncev, Gordana
   Gavrilovic, Aleksandar
   Aleksic, Dejan
TI Suffering from cerebral small vessel disease with and without metabolic
   syndrome
SO OPEN MEDICINE
LA English
DT Article
DE cerebral small vessel disease; cognitive impairment; depression;
   metabolic syndrome
ID QUALITY-OF-LIFE; COGNITIVE IMPAIRMENT; RISK-FACTORS; DEPRESSION;
   DEMENTIA; ASSOCIATIONS; STROKE
AB Background: Cerebral small vessel disease (CSVD) and metabolic syndrome were separately associated with cognitive impairment and depression. However, whether metabolic syndrome adds to cognitive impairment and depression in patients who already have CSVD remained unanswered.
   Objective: The aim of our study was to investigate the association of metabolic syndrome with cognitive impairment and depression in patients with CSVD who have lacunar lesions or white matter hyperintensities.
   Methods: This prospective cohort study was conducted at Neurology Clinic, Clinical Center, Kragujevac, Serbia. Main outcomes of the study were cognitive assessment, and assessment of depression among hospitalized patients with or without CSVD.
   Results: The study included 74 inpatients, 25 of them having lacunary infarctions, 24 with the white matter hyperintensities, and 25 control patients without CSVD. The CSVD was accompanied by impairment of cognition and depression, the patients with lacunary lesions being more cognitively impaired and more depressive than the patients with the white matter hyperintensities. The patients with CSVD who also had metabolic syndrome were more cognitively impaired and depressed than the patients with CSVD alone.
   Conclusions: In conclusion, our study showed that metabolic syndrome is associated with further worsening of already impaired cognition and existing depression in patients with CSVD.
C1 [Matic, Tatjana Boskovic] Clin Ctr Kragujevac, Clin Neurol, Zmaj Jovina 30, Kragujevac 34000, Serbia.
   [Toncev, Gordana; Gavrilovic, Aleksandar; Aleksic, Dejan] Univ Kragujevac, Fac Med Sci, Kragujevac, Serbia.
   [Toncev, Gordana; Gavrilovic, Aleksandar; Aleksic, Dejan] Univ Kragujevac, Clin Ctr, Kragujevac, Serbia.
C3 University of Kragujevac; University of Kragujevac
RP Matic, TB (corresponding author), Clin Ctr Kragujevac, Clin Neurol, Zmaj Jovina 30, Kragujevac 34000, Serbia.
EM stmatic@ptt.rs
RI Aleksić, Dejan/JGD-1786-2023
CR Baker JG, 2012, DEMENT GER COGN D EX, V2, P169, DOI 10.1159/000333482
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   Brown R, 2018, CARDIOVASC RES, V114, P1462, DOI 10.1093/cvr/cvy113
   Chornenkyy Y, 2019, BRAIN PATHOL, V29, P3, DOI 10.1111/bpa.12655
   Dearborn JL, 2015, STROKE, V46, P3131, DOI 10.1161/STROKEAHA.115.010060
   Efimova NY, 2015, CARDIOVASC THER, V33, P209, DOI 10.1111/1755-5922.12136
   Gyanwali B, 2019, J ALZHEIMERS DIS, V67, P1209, DOI 10.3233/JAD-180911
   Han F, 2018, J STROKE, V20, P239, DOI 10.5853/jos.2017.02110
   Hilal S, 2017, J NEUROL NEUROSUR PS, V88, P669, DOI 10.1136/jnnp-2016-315324
   Hollocks MJ, 2016, J INT NEUROPSYCH SOC, V22, P561, DOI 10.1017/S1355617716000187
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Majer R, 2019, OPEN MED-WARSAW, V14, P307, DOI 10.1515/med-2019-0028
   Marazziti D, 2014, CNS SPECTRUMS, V19, P293, DOI 10.1017/S1092852913000667
   Mok VCT, 2004, J NEUROL NEUROSUR PS, V75, P560, DOI 10.1136/jnnp.2003.015107
   Morimoto SS, 2015, ANN NY ACAD SCI, V1345, P36, DOI 10.1111/nyas.12669
   Mulvahill JS, 2017, J AM GERIATR SOC, V65, P2651, DOI 10.1111/jgs.15129
   Nasreddine ZS, 2005, J AM GERIATR SOC, V53, P695, DOI 10.1111/j.1532-5415.2005.53221.x
   OShea E., 2018, Aging Mental Health, P1
   Panza F, 2010, J ALZHEIMERS DIS, V21, P691, DOI 10.3233/JAD-2010-091669
   Rensma SP, 2018, NEUROSCI BIOBEHAV R, V90, P164, DOI 10.1016/j.neubiorev.2018.04.003
   Shi YL, 2016, STROKE VASC NEUROL, V1, P83, DOI 10.1136/svn-2016-000035
   Tiemeier H, 2003, EUR J EPIDEMIOL, V18, P745
   Yates KF, 2012, ARTERIOSCL THROM VAS, V32, P2060, DOI 10.1161/ATVBAHA.112.252759
NR 23
TC 5
Z9 5
U1 0
U2 3
PU DE GRUYTER POLAND SP Z O O
PI WARSAW
PA BOGUMILA ZUGA 32A STR, 01-811 WARSAW, MAZOVIA, POLAND
SN 2391-5463
J9 OPEN MED-WARSAW
JI Open Med.
PY 2019
VL 14
IS 1
BP 479
EP 484
DI 10.1515/med-2019-0051
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IJ1NY
UT WOS:000475666500001
PM 31231684
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sung, JD
   Choi, YH
   Park, JB
AF Sung, Jidong
   Choi, Yoon-Ho
   Park, Jeong Bae
TI Metabolic syndrome is associated with delayed heart rate recovery after
   exercise
SO JOURNAL OF KOREAN MEDICAL SCIENCE
LA English
DT Article
DE heart rate; heart rate recovery; metabolic syndrome X; vagal
   reactivation
ID TYPE-2 DIABETIC-PATIENTS; RATE-VARIABILITY; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; BLOOD-PRESSURE; ALL-CAUSE; PREDICTOR; MORTALITY;
   HYPERINSULINEMIA; DYSFUNCTION
AB Heart rate (HR) recovery after exercise is a function of vagal reactivation, and its impairment is a predictor of overall mortality and adverse cardiovascular events. While metabolic syndrome is associated with sympathetic overactivity, little is known about the relationship between metabolic syndrome and HR recovery. A symptom-limited exercise stress test in healthy subjects (n=1,434) was used to evaluate HR recovery. Metabolic syndrome was defined according to the National Cholesterol Education Program's Adult Treatment Panel III (NCEP ATP-III) criteria. Seventeen percent of subjects had !: 3 criteria for metabolic syndrome. HR recovery was lower in men than women and in smokers than nonsmokers. The subject with metabolic syndrome (vs. without) showed lower HR recovery (10.3 +/- 11.6 vs. 13.6 +/- 9.7 per minute) and higher resting HR (64.3 +/- 10.3 vs. 61.6 +/- 9.1 per minute). HR recovery correlated inversely to age (r=-0.25, p < 0.0001), but not to resting HR or maximal oxygen uptake. Delayed HR recovery was associated with metabolic syndrome after an adjustment for age, sex, resting HR and smoking (p < 0.01). Metabolic syndrome is associated with impaired vagal reactivation. Adverse cardiovascular outcomes associated with metabolic syndrome may be mediated by the failure of vagal reactivation in addition to sympathetic overactivity.
C1 Sungkyunkwan Univ, Sch Med, Dept Med Cardiol, Cheil Gen Hosp, Seoul 100380, South Korea.
   Sungkyunkwan Univ, Sch Med, Ctr Hlth Promot,Samsung Med Ctr, Cheil Gen Hosp, Seoul 100380, South Korea.
C3 Sungkyunkwan University (SKKU); Sungkyunkwan University (SKKU); Samsung
   Medical Center
RP Park, JB (corresponding author), Sungkyunkwan Univ, Sch Med, Dept Med Cardiol, Cheil Gen Hosp, 1-19 Mookjung Dong, Seoul 100380, South Korea.
EM parkjb@skku.edu
RI Choi, Yoon Ho/JXM-6303-2024; sung, jd/O-5936-2014
CR ARAI Y, 1989, AM J PHYSIOL, V256, pH132, DOI 10.1152/ajpheart.1989.256.1.H132
   Boden G, 2003, NEW ENGL J MED, V349, P1966, DOI 10.1056/NEJMcibr035229
   BORG G, 1970, Scandinavian Journal of Rehabilitation Medicine, V2, P92
   Cheng YLJ, 2003, DIABETES CARE, V26, P2052, DOI 10.2337/diacare.26.7.2052
   Cole CR, 2000, ANN INTERN MED, V132, P552, DOI 10.7326/0003-4819-132-7-200004040-00007
   Cole CR, 1999, NEW ENGL J MED, V341, P1351, DOI 10.1056/NEJM199910283411804
   DARR KC, 1988, AM J PHYSIOL, V254, pH340, DOI 10.1152/ajpheart.1988.254.2.H340
   Emdin M, 2001, CIRCULATION, V103, P513, DOI 10.1161/01.CIR.103.4.513
   Esler M, 2001, AM J HYPERTENS, V14, p304S, DOI 10.1016/S0895-7061(01)02236-1
   FERGUSON C, 2001, EXERCISE SPORTS CARD, P92
   Gottsäter A, 1999, DIABETIC MED, V16, P49, DOI 10.1046/j.1464-5491.1999.00001.x
   Greenland P, 1999, AM J EPIDEMIOL, V149, P853
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   HOLTZHAUSEN LM, 1995, MED SCI SPORT EXER, V27, P1595
   Janssen I, 2002, AM J CLIN NUTR, V75, P683, DOI 10.1093/ajcn/75.4.683
   JU DU, 2004, KOREAN J MED, V66, P586
   Kawahara E, 2003, CIRC J, V67, P753
   KIM HS, 2004, KOREAN CIRC J, V34, P170
   Krock L P, 1992, Clin Auton Res, V2, P89, DOI 10.1007/BF01819663
   Laitinen T, 1999, DIABETES, V48, P1295, DOI 10.2337/diabetes.48.6.1295
   Lind L, 2002, AM HEART J, V144, P666, DOI 10.1067/mhj.2002.124836
   Lindmark S, 2003, DIABETIC MED, V20, P399, DOI 10.1046/j.1464-5491.2003.00920.x
   Mensink GBM, 1997, EUR HEART J, V18, P1404
   Morshedi-Meibodi A, 2002, AM J CARDIOL, V90, P848, DOI 10.1016/S0002-9149(02)02706-6
   Palatini P, 1997, HYPERTENSION, V30, P1267, DOI 10.1161/01.HYP.30.5.1267
   Palatini P, 1999, J HYPERTENS, V17, pS3
   PETERSON HR, 1988, NEW ENGL J MED, V318, P1078
   Rissanen P, 2001, OBES RES, V9, P637, DOI 10.1038/oby.2001.84
   Rosenwinkel Eric T., 2001, Cardiology Clinics, V19, P369, DOI 10.1016/S0733-8651(05)70223-X
   Scheurink AJW, 1995, OBES RES, V3, pS721, DOI 10.1002/j.1550-8528.1995.tb00491.x
   Shetler K, 2001, J AM COLL CARDIOL, V38, P1980, DOI 10.1016/S0735-1097(01)01652-7
   Shishehbor MH, 2004, DIABETES CARE, V27, P936, DOI 10.2337/diacare.27.4.936
   Spies C, 2005, AM J CARDIOL, V95, P1175, DOI 10.1016/j.amjcard.2005.01.045
   Tiukinhoy Susan, 2003, J Cardiopulm Rehabil, V23, P84, DOI 10.1097/00008483-200303000-00002
   Vivekananthan DP, 2003, J AM COLL CARDIOL, V42, P831, DOI 10.1016/S0735-1097(03)00833-7
NR 35
TC 25
Z9 33
U1 0
U2 6
PU KOREAN ACAD MEDICAL SCIENCES
PI SEOUL
PA 302 75 DONG DU ICHON, DONG YONGSAN KU, SEOUL 140 031, SOUTH KOREA
SN 1011-8934
EI 1598-6357
J9 J KOREAN MED SCI
JI J. Korean Med. Sci.
PD AUG
PY 2006
VL 21
IS 4
BP 621
EP 626
DI 10.3346/jkms.2006.21.4.621
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 077OF
UT WOS:000240038500006
PM 16891803
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Chan, AML
   Ng, AMH
   Yunus, MHM
   Idrus, RBH
   Law, JX
   Yazid, MD
   Chin, KY
   Shamsuddin, SA
   Lokanathan, Y
AF Chan, Alvin Man Lung
   Ng, Angela Min Hwei
   Mohd Yunus, Mohd Heikal
   Idrus, Ruszymah Bt Hj
   Law, Jia Xian
   Yazid, Muhammad Dain
   Chin, Kok-Yong
   Shamsuddin, Sharen Aini
   Lokanathan, Yogeswaran
TI Recent Developments in Rodent Models of High-Fructose Diet-Induced
   Metabolic Syndrome: A Systematic Review
SO NUTRIENTS
LA English
DT Review
DE high fructose; metabolic syndrome; syndrome X; metabolic syndrome X;
   rodent; rat; mice; mouse
ID OXIDATIVE STRESS; RAT; ASSOCIATION; DYSFUNCTION; DISEASE; CONSUMPTION;
   ACTIVATION; GLUCOSE; WISTAR; TISSUE
AB Metabolic syndrome (MetS) is the physiological clustering of hypertension, hyperglycemia, hyperinsulinemia, dyslipidemia, and insulin resistance. The MetS-related chronic illnesses encompass obesity, the cardiovascular system, renal operation, hepatic function, oncology, and mortality. To perform pre-clinical research, it is imperative that these symptoms be successfully induced and optimized in lower taxonomy. Therefore, novel and future applications for a disease model, if proven valid, can be extrapolated to humans. MetS model establishment is evaluated based on the significance of selected test parameters, paradigm shifts from new discoveries, and the accessibility of the latest technology or advanced methodologies. Ultimately, the outcome of animal studies should be advantageous for human clinical trials and solidify their position in advanced medicine for clinicians to treat and adapt to serious or specific medical situations. Rodents (Rattus norvegicus and Mus musculus) have been ideal models for mammalian studies since the 18th century and have been mapped extensively. This review compiles and compares studies published in the past five years between the multitude of rodent comparative models. The response factors, niche parameters, and replicability of diet protocols are also compiled and analyzed to offer insight into MetS-related disease-specific modelling.
C1 [Chan, Alvin Man Lung; Ng, Angela Min Hwei; Idrus, Ruszymah Bt Hj; Law, Jia Xian; Yazid, Muhammad Dain; Shamsuddin, Sharen Aini; Lokanathan, Yogeswaran] Univ Kebangsaan Malaysia, Med Ctr, Fac Med, Ctr Tissue Engn & Regenerat Med, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
   [Chan, Alvin Man Lung] Ming Med Sdn Bhd, D3-3 2nd Floor,Block D3 Dana 1 Commercial Ctr, Petaling Jaya 47101, Malaysia.
   [Mohd Yunus, Mohd Heikal] Univ Kebangsaan Malaysia, Med Ctr, Fac Med, Dept Physiol, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
   [Chin, Kok-Yong] Univ Kebangsaan Malaysia, Med Ctr, Fac Med, Dept Pharmacol, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
C3 Universiti Kebangsaan Malaysia; Universiti Kebangsaan Malaysia;
   Universiti Kebangsaan Malaysia
RP Lokanathan, Y (corresponding author), Univ Kebangsaan Malaysia, Med Ctr, Fac Med, Ctr Tissue Engn & Regenerat Med, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
EM alvinchanmanlung@outlook.com; angela@ppukm.ukm.edu.my;
   mohdheikalyunus@yahoo.com; ruszymah@ppukm.ukm.edu.my;
   lawjx@ppukm.ukm.edu.my; dain@ukm.edu.my; chinkokyong@ppukm.ukm.edu.my;
   s.sharenaini@ppukm.ukm.edu.my; lyoges@ppukm.ukm.edu.my
RI Lokanathan, Yogeswaran/Q-5117-2019; Yazid, Muhammad/AAU-6355-2021; Chin,
   Kok-Yong/B-6309-2015; Law, Jia Xian/M-9728-2017; Mohd Yunus, Mohd
   Heikal/AAV-7037-2020
OI Chan, Alvin/0000-0001-9400-558X; Chin, Kok-Yong/0000-0001-6628-1552;
   Law, Jia Xian/0000-0001-9045-5145; Lokanathan,
   Yogeswaran/0000-0002-9548-6490; Yazid, Muhammad
   Dain/0000-0001-6162-4405; Mohd Yunus, Mohd Heikal/0000-0002-6793-2043
FU Ming Medical Sdn. Bhd. [FF-2020-469]; Universiti Kebangsaan Malaysia
   [FF-2020-469/1, DPK-2021-006]
FX This work was supported by grants by Ming Medical Sdn. Bhd.
   (FF-2020-469) and Universiti Kebangsaan Malaysia (FF-2020-469/1 and
   DPK-2021-006).
CR Abdelrahman AM, 2018, BIOMED PHARMACOTHER, V105, P182, DOI 10.1016/j.biopha.2018.05.118
   [Anonymous], 2020, Facts figures. International Diabetes Federation
   [Anonymous], 2020, OB OVERW
   Avena NM, 2008, NEUROSCI BIOBEHAV R, V32, P20, DOI 10.1016/j.neubiorev.2007.04.019
   Bantle JP, 2009, J NUTR, V139, pS1263, DOI 10.3945/jn.108.098020
   Boonyaratanakornkit V, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/140196
   Bratoeva K, 2018, METAB SYNDR RELAT D, V16, P350, DOI 10.1089/met.2017.0162
   Carvajal K., 2020, NUTR DIABETES, V10, P24
   Chen IH, 2018, LUTS, V10, P198, DOI 10.1111/luts.12156
   Chin KY, 2020, INT J MED SCI, V17, P2585, DOI 10.7150/ijms.49030
   Chow YY, 2020, MEDIAT INFLAMM, V2020, DOI 10.1155/2020/8293921
   Cordain L, 2005, AM J CLIN NUTR, V81, P341, DOI 10.1093/ajcn.81.2.341
   Corwin RL, 2011, PHYSIOL BEHAV, V104, P87, DOI 10.1016/j.physbeh.2011.04.041
   Gambaro SE, 2018, J NUTR BIOCHEM, V61, P173, DOI 10.1016/j.jnutbio.2018.08.004
   Fakhoury-Sayegh N, 2019, NUTR RES, V62, P101, DOI 10.1016/j.nutres.2018.11.003
   Ferreira-Santos P, 2020, J FUNCT FOODS, V73, DOI 10.1016/j.jff.2020.104098
   FONTVIEILLE AM, 1989, DIABETES CARE, V12, P481, DOI 10.2337/diacare.12.7.481
   Giles ED, 2016, FRONT NUTR, V3, DOI 10.3389/fnut.2016.00050
   Haller H., 1975, Lipidstoffwechselstorungen, P254
   Hannou SA, 2018, J CLIN INVEST, V128, P545, DOI 10.1172/JCI96702
   Herman MA, 2016, TRENDS ENDOCRIN MET, V27, P719, DOI 10.1016/j.tem.2016.06.005
   Hoyer S, 2002, J NEURAL TRANSM, V109, P991, DOI 10.1007/s007020200082
   Hsieh CC, 2016, J FOOD DRUG ANAL, V24, P754, DOI 10.1016/j.jfda.2016.03.005
   Kim M, 2020, KOREAN J PHYSIOL PHA, V24, P319, DOI 10.4196/kjpp.2020.24.4.319
   Kitagawa A, 2020, J NUTR SCI VITAMINOL, V66, P200, DOI 10.3177/jnsv.66.200
   Kolderup A, 2015, J NUTR METAB, V2015, DOI 10.1155/2015/823081
   Leeners B, 2017, HUM REPROD UPDATE, V23, P300, DOI 10.1093/humupd/dmw045
   Li YR, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0199293
   Lírio LM, 2016, J DIABETES COMPLICAT, V30, P85, DOI 10.1016/j.jdiacomp.2015.10.008
   Bargut TCL, 2017, PROSTAG LEUKOTR ESS, V123, P14, DOI 10.1016/j.plefa.2017.07.004
   Marques C, 2016, ADIPOCYTE, V5, P11, DOI 10.1080/21623945.2015.1061723
   Mohamad NV, 2020, ENDOCR METAB IMMUNE, V20, P1478, DOI 10.2174/1871530320666200604160614
   Moreira PI, 2007, J NEUROL SCI, V257, P206, DOI 10.1016/j.jns.2007.01.017
   Mustafa NG, 2020, INDIAN J ANIM RES, V54, P168, DOI 10.18805/ijar.B-1028
   Ng HY, 2018, KIDNEY BLOOD PRESS R, V43, P1822, DOI 10.1159/000495814
   Punthakee Z, 2018, CAN J DIABETES, V42, pS10, DOI 10.1016/j.jcjd.2017.10.003
   Ramos VW, 2017, REV PORT CARDIOL, V36, P937, DOI 10.1016/j.repc.2017.04.003
   Rattanavichit Y, 2016, AM J PHYSIOL-REG I, V311, pR1200, DOI 10.1152/ajpregu.00230.2016
   Rizkalla SW, 2010, NUTR METAB, V7, DOI 10.1186/1743-7075-7-82
   Roche HM, 2005, P NUTR SOC, V64, P371, DOI 10.1079/PNS2005445
   Rojas JM, 2018, TOXICOL PATHOL, V46, P777, DOI 10.1177/0192623318803557
   Sanders FWB, 2016, BIOL REV, V91, P452, DOI 10.1111/brv.12178
   Subramani Breetha, 2019, Biomedical & Pharmacology Journal, V12, P305, DOI 10.13005/bpj/1642
   Tappy L, 2019, J PHYSIOL-LONDON, V597, P3561, DOI [10.1113/JP278246, 10.1113/jp278246]
   Toth L.A., 2020, CONTEMP TOP LAB ANIM, V39, P17
   Vague J., 1958, RELATIONS OBESITE AR, V41, P1
   Wong SK, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0192416
   Wong SK, 2016, NUTRIENTS, V8, DOI 10.3390/nu8060347
   Zargaraan A., 2016, Nutrition and Food Sciences Research, V3, P3, DOI DOI 10.18869/ACADPUB.NFSR.3.4.3
   Zemanikova A, 2016, CURR TOP TOXICOL, V12, P25
   Zhang GL, 2020, BBA-MOL BASIS DIS, V1866, DOI 10.1016/j.bbadis.2019.165569
   Zhou C, 2008, ANN NY ACAD SCI, V1147, P93, DOI 10.1196/annals.1427.023
   Zhou JJ, 2013, BONE, V57, P30, DOI 10.1016/j.bone.2013.07.013
   Zhu J., 2019, HORMONE THERAPY REPL, DOI [10.5772/intechopen.89336, DOI 10.5772/INTECHOPEN.89336]
NR 54
TC 44
Z9 45
U1 1
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2021
VL 13
IS 8
AR 2497
DI 10.3390/nu13082497
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA UH4FF
UT WOS:000689888300001
PM 34444658
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vuksan-Cusa, B
   Jakovljevic, M
   Sagud, M
   Peles, AM
   Marcinko, D
   Topic, R
   Mihaljevic, S
   Sertic, J
AF Vuksan-Cusa, Bjanka
   Jakovljevic, Miro
   Sagud, Marina
   Peles, Alma Mihaljevic
   Marcinko, Darko
   Topic, Radmila
   Mihaljevic, Sanea
   Sertic, Jadranka
TI Metabolic syndrome and serum homocysteine in patients with bipolar
   disorder and schizophrenia treated with second generation antipsychotics
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Bipolar disorder; Schizophrenia; Homocysteine; Metabolic syndrome;
   Cardiovascular diseases
ID RISK-FACTORS; CARDIOVASCULAR-DISEASE; FOLATE; ASSOCIATION;
   HYPERHOMOCYSTEINEMIA; DEPRESSION; IMPACT
AB There is accumulating evidence for an increased prevalence of metabolic syndrome (MetS) in bipolar patients, which is comparable to the prevalence of MetS in patients with schizophrenia. Hyperhomocysteinaemia has emerged as an independent and graded risk factor for the development of cardiovascular disease (CVD), which is, at the same time, the primary clinical outcome of MetS. The aim of this study was to ascertain if the presence of MetS was associated with hyperhomocysteinaemia in patients with bipolar disorder (N = 36) and schizophrenia (N = 46) treated with second-generation antipsychotics (SGA). MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP-III) criteria and the cut-off point for hyperhomocysteinaemia was set up at 15 mu mol l(-1). Results of the study indicated that the presence of the MetS is statistically significantly associated with the elevated serum homocysteine in all participants. As hyperhomocysteinaemia has emerged as an independent risk factor for psychiatric disorder and CVD, it could be useful to include fasting homocysteine serum determination in the diagnostic panels of psychiatric patients to obtain a better assessment of their metabolic risk profile. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
C1 [Vuksan-Cusa, Bjanka; Jakovljevic, Miro; Sagud, Marina; Peles, Alma Mihaljevic; Marcinko, Darko; Topic, Radmila] Univ Hosp, Psychiat Clin, Zagreb, Croatia.
   [Mihaljevic, Sanea] Gen Hosp Tomislav Bardek, Virovitica, Croatia.
   [Sertic, Jadranka] Univ Hosp, Dept Lab Diagnost, Zagreb, Croatia.
RP Vuksan-Cusa, B (corresponding author), Univ Hosp, Psychiat Clin, Kispaticeva St, Zagreb, Croatia.
EM bjanka.vuksan@inet.hr
RI Sagud, Marina/G-1265-2015
OI Sagud, Marina/0000-0001-9620-2181
FU Ministry of Science, Education and Sport of the Republic of Croatia
   [01081]
FX This work was supported by the Ministry of Science, Education and Sport
   of the Republic of Croatia. Grant No.01081.
CR Akanji AO, 2007, CLIN BIOCHEM, V40, P1026, DOI 10.1016/j.clinbiochem.2007.06.001
   Applebaum J, 2004, J PSYCHIATR RES, V38, P413, DOI 10.1016/j.jpsychires.2004.01.003
   Assies J, 2004, PROSTAG LEUKOTR ESS, V70, P349, DOI 10.1016/j.plefa.2003.12.009
   Bellia Chiara, 2007, Ther Clin Risk Manag, V3, P999
   Birkenaes AB, 2007, J CLIN PSYCHIAT, V68, P917, DOI 10.4088/JCP.v68n0614
   Bobes J, 2012, EUR PSYCHIAT, V27, P267, DOI 10.1016/j.eurpsy.2010.09.001
   Calam RR, 2005, CLIN CHEM, V51, P1554, DOI 10.1373/clinchem.2005.054122
   Cardenas J, 2008, J AFFECT DISORDERS, V106, P91, DOI 10.1016/j.jad.2007.05.030
   Carmel R., 2003, American Society of Hematology. Education Program, P62
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Correll CU, 2008, BIPOLAR DISORD, V10, P788, DOI 10.1111/j.1399-5618.2008.00625.x
   Cortese C, 2001, Public Health Nutr, V4, P493
   Dierkes Jutta, 2005, Semin Vasc Med, V5, P124
   Dittmann S, 2007, BIPOLAR DISORD, V9, P63, DOI 10.1111/j.1399-5618.2007.00412.x
   Dittmann S, 2008, J CLIN PSYCHIAT, V69, P899, DOI 10.4088/JCP.v69n0603
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   Feng LG, 2009, PSYCHIAT RES, V168, P205, DOI 10.1016/j.psychres.2008.05.009
   Garcin J. -M., 2006, Metabolic Syndrome and Related Disorders, V4, P185, DOI 10.1089/met.2006.4.185
   Gilbody S, 2007, J EPIDEMIOL COMMUN H, V61, P631, DOI 10.1136/jech.2006.050385
   Gupta A, 2010, BIOSCI TRENDS, V4, P204
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Herrmann W, 2007, FORTSCHR NEUROL PSYC, V75, P515, DOI 10.1055/s-2007-980112
   Hirsch S, 2004, J NUTR, V134, P1832, DOI 10.1093/jn/134.7.1832
   Kay S.R., 1987, SCHIZOPHRENIA B, P261
   Kilbourne AM, 2007, PSYCHOSOMATICS, V48, P412, DOI 10.1176/appi.psy.48.5.412
   Levine J, 2005, PROG NEURO-PSYCHOPH, V29, P1181, DOI 10.1016/j.pnpbp.2005.06.029
   Levine J, 2002, AM J PSYCHIAT, V159, P1790, DOI 10.1176/appi.ajp.159.10.1790
   Lonn Eva, 2006, Current Vascular Pharmacology, V4, P253, DOI 10.2174/157016106777698360
   Mangoni AA, 2002, AM J MED, V112, P556, DOI 10.1016/S0002-9343(02)01021-5
   Neeman G, 2005, AM J PSYCHIAT, V162, P1738, DOI 10.1176/appi.ajp.162.9.1738
   Ninomiya JK, 2004, CIRCULATION, V109, P42, DOI 10.1161/01.CIR.0000108926.04022.0C
   Obeid R., 2007, CLIN BIOCHEM, V40, P1026
   Osher Y, 2004, BIPOLAR DISORD, V6, P82, DOI 10.1046/j.1399-5618.2003.00082.x
   Ozbek Z, 2008, PROG NEURO-PSYCHOPH, V32, P1331, DOI 10.1016/j.pnpbp.2008.04.016
   Regitz-Zagrosek V, 2006, CLIN RES CARDIOL, V95, P136, DOI 10.1007/s00392-006-0351-5
   Reif A, 2005, PROG NEURO-PSYCHOPH, V29, P1162, DOI 10.1016/j.pnpbp.2005.06.027
   Sarandol A, 2007, J PSYCHOPHARMACOL, V21, P857, DOI 10.1177/0269881107077609
   STABLER SP, 1987, ANAL BIOCHEM, V162, P185, DOI 10.1016/0003-2697(87)90026-1
   Stanger O, 2009, EXPERT REV NEUROTHER, V9, P1393, DOI 10.1586/ERN.09.75
   To-Figueras J, 2010, METABOLISM, V59, P1809, DOI 10.1016/j.metabol.2010.05.016
   Vuksan-Cusa B, 2009, PROG NEURO-PSYCHOPH, V33, P109, DOI 10.1016/j.pnpbp.2008.10.017
   *WHO, 1996, WHO INT STAT CLASS D
   YOUNG RC, 1978, BRIT J PSYCHIAT, V133, P429, DOI 10.1192/bjp.133.5.429
NR 43
TC 30
Z9 33
U1 0
U2 10
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD AUG 30
PY 2011
VL 189
IS 1
BP 21
EP 25
DI 10.1016/j.psychres.2010.11.021
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 822TW
UT WOS:000295073500003
PM 21216014
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Vepa, A
   Joseph, PB
   Ahmed, F
   Pareek, M
   Khunti, K
AF Vepa, Abhinav
   Joseph, P. Bae
   Ahmed, Faheem
   Pareek, Manish
   Khunti, Kamlesh
TI COVID-19 and ethnicity: A novel pathophysiological role for inflammation
SO DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
LA English
DT Article
DE COVID-19; SARS CoV-2; BAME; Ethnicity; Metabolic syndrome; Type 2
   diabetes mellitus; Obesity; Inflammation; Insulin resistance;
   Cardiovascular risk; Cytokine storm; Visceral fat; Psychological stress
ID METABOLIC SYNDROME; PSYCHOLOGICAL STRESS; OXIDATIVE STRESS;
   MENTAL-ILLNESS; SLEEP-APNEA; HEALTH; RISK; PREVALENCE; DISEASE; OBESITY
AB Introduction: There have been recent mounting concerns regarding multiple reports stating a significantly elevated relative-risk of COVID-19 mortality amongst the Black and Minority Ethnic (BAME) population. An urgent national enquiry investigating the possible reasons for this phenomenon has been issued in the UK. Inflammation is at the forefront of COVID-19 research as disease severity appears to correlate with pro-inflammatory cytokine dysregulation. This narrative review aims to shed light on the novel, pathophysiological role of inflammation in contributing towards the increased COVID-19 mortality risk amongst the BAME population.
   Methods: Searches in PubMed, Medline, Scopus, medRxiv and Google Scholar were performed to identify articles published in English from inception to 18th June 2020. These databases were searched using keywords including: 'COVID-19' or 'Black and Minority Ethnic' or 'Inflammation'. A narrative review was synthesized using these included articles.
   Results: We suggest a novel pathophysiological mechanism by which acute inflammation from COVID-19 may augment existing chronic inflammation, in order to potentiate a 'cytokine storm' and thus the more severe disease phenotype observed in the BAME population. Obesity, insulin resistance, cardiovascular disease, psychological stress, chronic infections and genetic predispositions are all relevant factors which may be contributing to elevated chronic systemic inflammation amongst the BAME population.
   Conclusion: Overall, this review provides early insights and directions for ongoing research regarding the pathophysiological mechanisms that may explain the severe COVID-19 disease phenotype observed amongst the BAME population. We suggest 'personalization' of chronic disease management, which can be used with other interventions, in order to tackle this. (c) 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.
C1 [Vepa, Abhinav; Joseph, P. Bae] Milton Keynes Univ Hosp NHS Fdn Trust, Dept Med, Milton Keynes, Bucks, England.
   [Ahmed, Faheem] NHS England, Skipton House, London, England.
   [Pareek, Manish] Univ Leicester, Dept Resp Sci, Leicester, Leics, England.
   [Khunti, Kamlesh] Univ Leicester, Diabet Res Ctr, Leicester, Leics, England.
C3 University of Leicester; University of Leicester
RP Vepa, A (corresponding author), Milton Keynes Univ Hosp NHS Fdn Trust, Dept Med, Milton Keynes, Bucks, England.
EM Vepa.Abhinav@nhs.net
RI /GQB-2573-2022; Ahmed, Faheem/KDN-1745-2024
OI Pareek, Manish/0000-0003-1521-9964; Khunti, Kamlesh/0000-0003-2343-7099;
   Vepa, Abhinav/0000-0001-5858-1109
FU National Institute for Health Research (NIHR) Applied Research
   Collaboration East Midlands (ARC EM); NIHR Leicester Biomedical Research
   Centre (BRC); COVID [MR/V027549/1] Funding Source: UKRI
FX KK is supported by the National Institute for Health Research (NIHR)
   Applied Research Collaboration East Midlands (ARC EM) and the NIHR
   Leicester Biomedical Research Centre (BRC). The views expressed are
   those of the author(s) and not necessarily those of the NIHR, NHS or the
   Department of Health and Social Care.
CR [Anonymous], 2021, ONS Statistical Bulletin
   [Anonymous], 2020, STROKE VASC NEUROL
   Antonia P., 2020, OBESITY COVID 19 ROL, DOI [10.1101/2020.05.14.20101998, DOI 10.1101/2020.05.14.20101998]
   Babapoor-Farrokhran S, 2020, LIFE SCI, V253, DOI 10.1016/j.lfs.2020.117723
   Balfour PC, 2015, CURR CARDIOVASC RISK, V9, DOI 10.1007/s12170-015-0446-5
   Barnes BJ, 2020, J EXP MED, V217, DOI 10.1084/jem.20200652
   Barnett P, 2019, LANCET PSYCHIAT, V6, P305, DOI 10.1016/S2215-0366(19)30027-6
   Bawazir A, 2018, J INFECT PUBLIC HEAL, V11, P89, DOI 10.1016/j.jiph.2017.05.003
   Black CN, 2015, PSYCHONEUROENDOCRINO, V51, P164, DOI 10.1016/j.psyneuen.2014.09.025
   Blair C, 2016, ACAD PEDIATR, V16, pS30, DOI 10.1016/j.acap.2016.01.010
   BMJ, 2020, BRIT MED J
   Bonow RO, 2020, JAMA CARDIOL, V5, P751, DOI 10.1001/jamacardio.2020.1105
   Cappuccio Francesco P., 2001, Ethnicity and Disease, V11, P11
   Caussy C, 2020, OBESITY, V28, P1175, DOI 10.1002/oby.22842
   Clair A, 2019, J EPIDEMIOL COMMUN H, V73, P256, DOI 10.1136/jech-2018-211431
   Conran N, 2018, CLIN HEMORHEOL MICRO, V68, P263, DOI 10.3233/CH-189012
   Cook T, 2020, Health Service J
   De Miguel C, 2015, CURR HYPERTENS REP, V17, DOI 10.1007/s11906-014-0507-z
   DeBoer MD, 2011, EXPERT REV ENDOCRINO, V6, P279, DOI 10.1586/EEM.11.17
   Deeks SG, 2013, IMMUNITY, V39, P633, DOI 10.1016/j.immuni.2013.10.001
   Dhar AK, 2016, FRONT PSYCHIATRY, V7, DOI 10.3389/fpsyt.2016.00033
   Docherty AB, 2020, FEATURES 16749 HOSPI, DOI DOI 10.1136/BMJ.M198532444460
   Drager LF, 2013, J AM COLL CARDIOL, V62, P569, DOI 10.1016/j.jacc.2013.05.045
   Eborall H, 2020, ECLINICALMEDICINE, V21, DOI [10.1016/j.eclinm.2020.100315, 10.1016/eclinm.2020.100315]
   Ellinghaus D, 2020, GENOMEWIDE ASS STUDY
   Ellulu MS, 2017, ARCH MED SCI, V13, P851, DOI 10.5114/aoms.2016.58928
   Emami A, 2020, ARCH ACAD EMERG MED, V8, DOI 10.22037/aaem.v8i1.600
   Fan JL, 2020, METABOLISM, V107, DOI 10.1016/j.metabol.2020.154243
   Feltes PK, 2017, J PSYCHOPHARMACOL, V31, P1149, DOI 10.1177/0269881117711708
   Frank ATH, 2014, CIRCULATION, V129, P570, DOI 10.1161/CIRCULATIONAHA.113.005757
   Fu LW, 2020, J INFECTION, V80, P656, DOI 10.1016/j.jinf.2020.03.041
   Galic S, 2010, MOL CELL ENDOCRINOL, V316, P129, DOI 10.1016/j.mce.2009.08.018
   Garg S, 2020, MMWR-MORBID MORTAL W, V69, P458, DOI 10.15585/mmwr.mm6915e3
   Geovanini GR, 2018, ANN AM THORAC SOC, V15, P970, DOI 10.1513/AnnalsATS.201802-121OC
   Glaser R, 2005, NAT REV IMMUNOL, V5, P243, DOI 10.1038/nri1571
   Goff LM, 2019, DIABETIC MED, V36, P927, DOI 10.1111/dme.13895
   Gonzalez H, 2008, ANESTH ANALG, V106, P1132, DOI 10.1213/ane.0b013e3181679659
   GOV .UK, 2017, LAMM REV
   GOV.UK, 2019, HLTH EAT AD
   GOV.UK, 2018, OV HOUS
   GOV UK, 2019, PHYS IN
   GOV.UK, 2018, Regional ethnic diversity
   GOV.UK, 2019, OV AD
   GOV.UK, 2020, HIV UK
   Gray LJ, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026464
   Grillet F, 2020, RADIOLOGY, V296, pE186, DOI 10.1148/radiol.2020201544
   Guaraldi G, 2011, CLIN INFECT DIS, V53, P1120, DOI 10.1093/cid/cir627
   Guo T, 2020, JAMA CARDIOL, V5, P811, DOI 10.1001/jamacardio.2020.1017
   Härter G, 2020, INFECTION, V48, P681, DOI 10.1007/s15010-020-01438-z
   Hargreaves S, 2014, BMC INFECT DIS, V14, DOI 10.1186/s12879-014-0657-2
   Harris RJ, 2012, EUR J PUBLIC HEALTH, V22, P187, DOI 10.1093/eurpub/ckr083
   Haynes TF, 2017, PSYCHIAT SERV, V68, P573, DOI 10.1176/appi.ps.201600208
   Huang C., 2020, Lancet, V395, P497, DOI [DOI 10.1016/S0140-6736(20)30183-5, 10.1016/50140- 6736(20)30183-5]
   Icnarc, 2020, ICNARC report on COVID-19 in critical care
   Jiménez-Fernández S, 2015, J CLIN PSYCHIAT, V76, P1658, DOI 10.4088/JCP.14r09179
   Kalia HS, 2016, CLIN LIVER DIS, V20, P215, DOI 10.1016/j.cld.2015.10.005
   Kalmbach DA, 2018, J SLEEP RES, V27, DOI 10.1111/jsr.12710
   Kang YE, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0154003
   Kiecolt-Glaser JK, 2010, PSYCHOSOM MED, V72, P365, DOI 10.1097/PSY.0b013e3181dbf489
   Kim SR, 2008, BBA-MOL CELL RES, V1783, P886, DOI 10.1016/j.bbamcr.2008.01.004
   Köhler CA, 2017, ACTA PSYCHIAT SCAND, V135, P373, DOI 10.1111/acps.12698
   Kritikou I, 2013, EUR RESPIR J, V41, P601, DOI 10.1183/09031936.00183411
   Kwong JC, 2018, NEW ENGL J MED, V378, P345, DOI 10.1056/NEJMoa1702090
   Lackland DT, 2014, AM J MED SCI, V348, P135, DOI 10.1097/MAJ.0000000000000308
   Lear SA, 2007, AM J CLIN NUTR, V86, P353, DOI 10.1093/ajcn/86.2.353
   Li B, 2020, CLIN RES CARDIOL, V109, P531, DOI 10.1007/s00392-020-01626-9
   Lip GYH, 2007, J HUM HYPERTENS, V21, P183, DOI 10.1038/sj.jhh.1002126
   Lira FS, 2014, CURR DIABETES REV, V10, P391, DOI 10.2174/1573399810666141122210135
   Liu BW, 2020, J AUTOIMMUN, V111, DOI 10.1016/j.jaut.2020.102452
   Liu T, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0138904
   Long B, 2020, AM J EMERG MED, V38, P1504, DOI 10.1016/j.ajem.2020.04.048
   Luo P, 2020, J MED VIROL, V92, P814, DOI 10.1002/jmv.25801
   Ma K, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17050733
   Mangrio Elisabeth, 2018, BMC Res Notes, V11, P609, DOI 10.1186/s13104-018-3718-6
   Mantovani N, 2017, HEALTH EXPECT, V20, P373, DOI 10.1111/hex.12464
   McSharry D, 2020, J CLIN SLEEP MED, V16, P1645, DOI 10.5664/jcsm.8538
   Memon A, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2016-012337
   Merad M, 2020, NAT REV IMMUNOL, V20, P355, DOI 10.1038/s41577-020-0331-4
   Mohanty SR, 2009, J HEPATOL, V50, P797, DOI 10.1016/j.jhep.2008.11.017
   Mullington JM, 2010, BEST PRACT RES CL EN, V24, P775, DOI 10.1016/j.beem.2010.08.014
   National Institute for Health and Care Excellence (NICE), 2013, BMI PREV ILL HLTH PR
   Nédélec Y, 2016, CELL, V167, P657, DOI 10.1016/j.cell.2016.09.025
   Nguyen JL, 2016, JAMA CARDIOL, V1, P274, DOI 10.1001/jamacardio.2016.0433
   NHS, 2020, WORKF RAC EQ STAND D
   Norrie R., 2017, POLICY EXCHANGE
   O'Donovan A, 2012, BRAIN BEHAV IMMUN, V26, P642, DOI 10.1016/j.bbi.2012.02.003
   Office for National Statistics-United Kingdom, 2021, Deaths involving COVID-19 by vaccination status, England: deaths occurring between January 1 and October 31 2021
   ONS, 2019, ETHN PAY GAPS GREAT
   ONS, 2020, COR COVID 19 REL DEA
   ONS, 2020, COR COVID 19 REL DEA
   Paalani M, 2011, ETHNIC DIS, V21, P142
   Pan D, 2020, ECLINICALMEDICINE, V23, DOI 10.1016/j.eclinm.2020.100404
   Paoletti R, 2006, VASC HEALTH RISK MAN, V2, P145, DOI 10.2147/vhrm.2006.2.2.145
   Park HK, 2017, KOREAN J INTERN MED, V32, P239, DOI 10.3904/kjim.2016.229
   Peng K, 2020, OSTEOPOROSIS INT, V31, P1545, DOI 10.1007/s00198-020-05393-1
   Poulain M, 2006, CAN MED ASSOC J, V174, P1293, DOI 10.1503/cmaj.051299
   Pu J, 2015, CARDIOL CLIN, V33, P325, DOI 10.1016/j.ccl.2015.01.005
   Public Health England [PHE], 2020, PHE INV NOV VAR COVI
   Quinn K, 2010, J URBAN HEALTH, V87, P688, DOI 10.1007/s11524-010-9465-1
   Radha V, 2007, INDIAN J MED RES, V125, P259
   Rao Jakkula V, 2012, Indian J Occup Environ Med, V16, P22, DOI 10.4103/0019-5278.99686
   Ravimohan S, 2018, EUR RESPIR REV, V27, DOI 10.1183/16000617.0077-2017
   Razieh C, 2019, DIABETIC MED, V36, P1158, DOI 10.1111/dme.13986
   Richardson S, 2020, JAMA-J AM MED ASSOC, V323, P2052, DOI 10.1001/jama.2020.6775
   Roy NBA, 2020, BRIT J HAEMATOL, V189, P635, DOI 10.1111/bjh.16687
   Ruan QR, 2020, INTENS CARE MED, V46, P1294, DOI 10.1007/s00134-020-06028-z
   Russell B, 2020, ECANCERMEDICALSCIENC, V14, P1, DOI 10.3332/ecancer.2020.1022
   Saddi-Rosa P, 2010, DIABETOL METAB SYNDR, V2, DOI 10.1186/1758-5996-2-21
   Schouten J, 2014, CLIN INFECT DIS, V59, P1787, DOI 10.1093/cid/ciu701
   Segerstrom SC, 2004, PSYCHOL BULL, V130, P601, DOI 10.1037/0033-2909.130.4.601
   Shen TC, 2014, EUR J INTERN MED, V25, P936, DOI 10.1016/j.ejim.2014.10.006
   Shi SB, 2020, JAMA CARDIOL, V5, P802, DOI 10.1001/jamacardio.2020.0950
   Simonnet A, 2020, OBESITY, V28, P1195, DOI 10.1002/oby.22831
   Singal AK, 2019, TRANSL GASTROENT HEP, V4, DOI 10.21037/tgh.2019.09.11
   Singh AK, 2020, DIAB MET SYND CLIN R, V14, P283, DOI 10.1016/j.dsx.2020.03.016
   Srikanthan K, 2016, INT J MED SCI, V13, P25, DOI 10.7150/ijms.13800
   Sturgeon JA, 2016, PSYCHOSOM MED, V78, P134, DOI 10.1097/PSY.0000000000000276
   Tay MZ, 2020, NAT REV IMMUNOL, V20, P363, DOI 10.1038/s41577-020-0311-8
   Tersalvi G, 2020, J CARD FAIL, V26, P470, DOI 10.1016/j.cardfail.2020.04.009
   Teuwen LA, 2020, NAT REV IMMUNOL, V20, P389, DOI 10.1038/s41577-020-0343-0
   Toossi Z., 2000, ARCH IMMUNOL THER EX, V48
   Tsai YC, 2012, BMC HEALTH SERV RES, V12, DOI 10.1186/1472-6963-12-199
   Tsalamandris S, 2019, EUR CARDIOL REV, V14, P50, DOI 10.15420/ecr.2018.33.1
   Vermeulen-Smit E, 2015, J AFFECT DISORDERS, V171, P111, DOI 10.1016/j.jad.2014.09.031
   Walker AJ, 2020, OPENSAFELY FACTORS A, DOI [DOI 10.1101/2020.05.06.20092999, 10.1101/20 20.05.06.20092999, 10.1038/s41586-020-2521-4]
   Wang TT, 2018, BMC PSYCHIATRY, V18, DOI 10.1186/s12888-018-1741-8
   Ward EC, 2013, NURS RES, V62, P185, DOI 10.1097/NNR.0b013e31827bf533
   Whincup PH, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000263
   Wilkinson E, 2015, LANCET, V385, P841, DOI 10.1016/S0140-6736(15)60470-6
   Williams DR, 2018, J HEALTH SOC BEHAV, V59, P466, DOI 10.1177/0022146518814251
   Xu Zhe, 2020, Lancet Respir Med, V8, P420, DOI 10.1016/S2213-2600(20)30076-X
   Yang CZ, 2020, JAMA CARDIOL, V5, P743, DOI 10.1001/jamacardio.2020.0934
   Yates T, 2020, PRIM CARE DIABETES, V14, P566, DOI 10.1016/j.pcd.2020.05.011
   Yates T, 2012, AM J PREV MED, V42, P1, DOI 10.1016/j.amepre.2011.09.022
   Yeyeodu ST, 2019, CANCER IMMUNOL RES, V7, P1384, DOI 10.1158/2326-6066.CIR-18-0564
   You TJ, 2013, SPORTS MED, V43, P243, DOI 10.1007/s40279-013-0023-3
   Youman K, 2010, PSYCHOL SERV, V7, P11, DOI 10.1037/a0017864
   Yuan HB, 2013, SLEEP, V36, P1199, DOI 10.5665/sleep.2886
   Yuan N, 2019, TRANSL PSYCHIAT, V9, DOI 10.1038/s41398-019-0570-y
   Yuki K, 2020, CLIN IMMUNOL, V215, DOI 10.1016/j.clim.2020.108427
   Zaim S, 2020, CURR PROB CARDIOLOGY, V45, DOI 10.1016/j.cpcardiol.2020.100618
   Zampino R, 2013, WORLD J HEPATOL, V5, P528, DOI 10.4254/wjh.v5.i10.528
   Ziol-Guest KM, 2012, P NATL ACAD SCI USA, V109, P17289, DOI 10.1073/pnas.1203167109
NR 143
TC 41
Z9 42
U1 0
U2 15
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-4021
EI 1878-0334
J9 DIABETES METAB SYND
JI Diabetes Metab. Syndr.-Clin. Res. Rev.
PD SEP-OCT
PY 2020
VL 14
IS 5
BP 1043
EP 1051
DI 10.1016/j.dsx.2020.06.056
PG 9
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA OG9KS
UT WOS:000582194300069
PM 32640416
OA Green Published
DA 2025-06-11
ER

PT J
AU Wang, Q
   Chair, SY
   Wong, EML
AF Wang, Qun
   Chair, Sek Ying
   Wong, Eliza Mi-Ling
TI The effects of a lifestyle intervention program on physical outcomes,
   depression, and quality of life in adults with metabolic syndrome: A
   randomized clinical trial
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Metabolic syndrome; Lifestyle intervention; Body weight; Depression
   Quality of life
ID ACUTE CORONARY SYNDROME; CARDIOVASCULAR RISK; WEIGHT-LOSS; HOSPITAL
   ANXIETY; KOREAN ADULTS; HEALTH; EXERCISE; METAANALYSIS; EDUCATION;
   FITNESS
AB Background/objectives: Lifestyle modification is recommended as the primary intervention for metabolic syndrome (MetS). The study was to examine the effects of a lifestyle intervention program (LIP) on physical outcomes, depression, and quality of life (QoL) in Chinese adults with MetS.
   Methods: A randomized control trial design was used. A three-month LIP guided by the Health Promotion Model was developed, including a lifestyle modification booklet, one session of discharge education, and six telephone follow-ups. Patients with MetS were recruited from the inpatient departments of a hospital and were randomized to receive either the LIP or usual care. The physical outcomes, depression (Depression subscale of Hospital Anxiety and Depression Scale), and QoL (Medical Outcome Study Short Form-12, SF-12) were measured at baseline, one-month (T1) and three-month (T2). The effects of the LIP were examined by the generalized estimating equation (GEE) model.
   Results: The study recruited 173 participants, with 86 in the intervention group and 87 in the control. Continuous improvements were observed in all the study outcomes in the intervention group. The GEE model revealed significant improvements in body weight (T1: p - 0.017, T2: p - 0.007), body mass index (T1: p - 0.015, T2: p = 0.009), depression (T1: p = 0.027, T2: p < 0.001), and physical aspects of QoL at T2 (p= 0.02).
   Conclusions: The current LIP was effective in losing body weight, improving depression and QoL ofMetS populations in three-month observation. Considering its low-cost and convenience, the LIP could be applied in clinical practice to improve patient outcomes. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Wang, Qun; Chair, Sek Ying; Wong, Eliza Mi-Ling] Chinese Univ Hong Kong, Nethersole Sch Nursing, Shatin, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong
RP Wang, Q (corresponding author), Chinese Univ Hong Kong, Room 821,Esther Lee Bldg, Shatin, Hong Kong, Peoples R China.
EM qunwang@cuhk.edu.hk
RI Chair, Sek/IVV-5916-2023; Wong, Eliza/AAH-6193-2020; WANG,
   Qun/AAP-9908-2021; Chair, Sek Ying/G-9965-2016
OI Chair, Sek Ying/0000-0003-2387-7035; Wong, Eliza ML/0000-0003-0698-9000;
   Wang, Qun/0000-0001-7594-8312
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Aizawa K, 2009, DIABETES RES CLIN PR, V83, P249, DOI 10.1016/j.diabres.2008.11.016
   American College of Cardiology; American Heart Association Task Force on Practice Guidelines, 2007, CATHETER CARDIOVASC, V71, pE1, DOI DOI 10.1002/CCD.21475
   [Anonymous], 1993, CHIN J BEHAV MED
   BARCZAK P, 1988, BRIT J PSYCHIAT, V152, P698, DOI 10.1192/bjp.152.5.698
   Butnoriene J, 2014, PSYCHONEUROENDOCRINO, V40, P269, DOI 10.1016/j.psyneuen.2013.11.002
   Cao Q. K., 2013, PREV MED TRIB, V19, P9
   Carr DB, 2004, DIABETES, V53, P2087, DOI 10.2337/diabetes.53.8.2087
   Carroll S, 2007, APPL PHYSIOL NUTR ME, V32, P125, DOI 10.1139/h06-093
   Chair SY, 2012, EUR J PREV CARDIOL, V19, P1383, DOI 10.1177/1741826711425428
   Chaput JP, 2007, DEPRESS ANXIETY, V24, P518, DOI 10.1002/da.20264
   Christian JG, 2011, J AM DIET ASSOC, V111, P75, DOI 10.1016/j.jada.2010.10.006
   Clavijo LC, 2006, CARDIOVASC REVASCULA, V7, P7, DOI 10.1016/j.carrev.2005.10.007
   Cohen J., 1988, STAT POWER ANAL BEHA, DOI [10.4324/9780203771587, DOI 10.4324/9780203771587]
   Curtis LH, 2007, DIABETES CARE, V30, P2553, DOI 10.2337/dc07-0460
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   Dunkley AJ, 2012, DIABETES OBES METAB, V14, P616, DOI 10.1111/j.1463-1326.2012.01571.x
   Farquhar J, 2005, CULT ANTHROPOL, V20, P303, DOI 10.1525/can.2005.20.3.303
   Ford ES, 2008, ANN EPIDEMIOL, V18, P165, DOI 10.1016/j.annepidem.2007.10.009
   Hauck WW, 1998, CONTROL CLIN TRIALS, V19, P249, DOI 10.1016/S0197-2456(97)00147-5
   Hoffman BM, 2007, HEALTH PSYCHOL, V26, P1, DOI 10.1037/0278-6133.26.1.1
   International Diabetes Federation, 2006, IDF CONS WORLDW DEF
   Irwin ML, 2003, JAMA-J AM MED ASSOC, V289, P323, DOI 10.1001/jama.289.3.323
   Kim CJ, 2011, J CARDIOVASC NURS, V26, P117, DOI 10.1097/JCN.0b013e3181ec02ae
   Kim CJ, 2010, J CARDIOVASC NURS, V25, P323, DOI 10.1097/JCN.0b013e3181c8a3e8
   Lakkireddy D, 2013, J AM COLL CARDIOL, V61, P1177, DOI 10.1016/j.jacc.2012.11.060
   Lam CLK, 2005, J CLIN EPIDEMIOL, V58, P815, DOI 10.1016/j.jclinepi.2004.12.008
   Lao X. Q., 2014, BMC PUBLIC HEALTH, V14, pe1
   Lee YJ, 2012, ANN NUTR METAB, V61, P275, DOI 10.1159/000341494
   Li CG, 2013, CURR OPIN RHEUMATOL, V25, P210, DOI 10.1097/BOR.0b013e32835d951e
   Lichtman JH, 2014, CIRCULATION, V129, P1350, DOI 10.1161/CIR.0000000000000019
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Mrazek P. J., 1994, DESIGNING CONDUCTING
   Mujica V, 2010, J AM SOC HYPERTENS, V4, P148, DOI 10.1016/j.jash.2010.02.008
   Munakata M, 2011, HYPERTENS RES, V34, P612, DOI 10.1038/hr.2010.272
   Nanri A, 2012, J OCCUP HEALTH, V54, P215, DOI 10.1539/joh.11-0238-OA
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Oh EG, 2010, METABOLISM, V59, P1035, DOI 10.1016/j.metabol.2009.10.027
   Oh EG, 2008, METABOLISM, V57, P255, DOI 10.1016/j.metabol.2007.09.009
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pattyn N, 2013, SPORTS MED, V43, P121, DOI 10.1007/s40279-012-0003-z
   Pazzagli C, 2013, PSYCHOL REP, V112, P33, DOI 10.2466/06.13.15.PR0.112.1.33-46
   Pender N.J., 1987, Health promotion in nursing practice, V2nd
   Rauch A, 2010, GASTROENTEROLOGY, V138, P1338, DOI 10.1053/j.gastro.2009.12.056
   Regitz-Zagrosek V, 2006, CLIN RES CARDIOL, V95, P136, DOI 10.1007/s00392-006-0351-5
   Ross KM, 2009, EAT BEHAV, V10, P84, DOI 10.1016/j.eatbeh.2008.12.002
   Rubenfire M, 2011, J CARDIOPULM REHABIL, V31, P282, DOI 10.1097/HCR.0b013e318220a7eb
   Schlotz W, 2007, QUAL LIFE RES, V16, P429, DOI 10.1007/s11136-006-9129-5
   Soares TS, 2014, ARQ BRAS CARDIOL, V102, P374
   Trief PM, 2014, OBESITY, V22, P2532, DOI 10.1002/oby.20916
   Tziallas D, 2012, EUR J CARDIOVASC NUR, V11, P297, DOI 10.1016/j.ejcnurse.2011.02.004
   Wang Q, 2014, METAB SYNDR RELAT D, V12, P390, DOI 10.1089/met.2014.0010
   Wang WR, 2009, J CLIN NURS, V18, P2436, DOI 10.1111/j.1365-2702.2009.02807.x
   Ware JE, 2000, SPINE, V25, P3130, DOI 10.1097/00007632-200012150-00008
   Ware John E., 1995, SF-12: How to Score the SF-12 Physical and Mental Health Summary Scales
   World Health Organization, 2011, Waist circumference and waist-hip ratio: report of a WHO expert consultation
   Xu QY, 2011, OBES RES CLIN PRACT, V5, pE267, DOI 10.1016/j.orcp.2011.04.007
   Yamaoka K, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-138
   Zhang SX, 2011, ASIA PAC J CLIN NUTR, V20, P77
NR 59
TC 43
Z9 45
U1 2
U2 27
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD MAR 1
PY 2017
VL 230
BP 461
EP 467
DI 10.1016/j.ijcard.2016.12.084
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA EQ2MQ
UT WOS:000397904000073
PM 28040281
DA 2025-06-11
ER

PT J
AU Tanaka, G
   Kato, Y
   Matsumura, K
   Horiguchi, M
   Ogasawara, H
   Sawada, Y
AF Tanaka, Gohichi
   Kato, Yuichi
   Matsumura, Kenta
   Horiguchi, Masami
   Ogasawara, Haruko
   Sawada, Yukihiro
TI The association between chronic psychosocial stress, allostatic load,
   and vascular health in asymptomatic young men: A pilot study using a
   novel finger arterial stiffness index
SO JAPANESE PSYCHOLOGICAL RESEARCH
LA English
DT Article
DE arterial stiffness; small artery and arteriole; allostatic load;
   psychosocial stress; cardiovascular health
ID C-REACTIVE PROTEIN; INSULIN-RESISTANCE SYNDROME; CARDIOVASCULAR RISK;
   METABOLIC SYNDROME; BLOOD-PRESSURE; CLINICAL-APPLICATIONS; DISEASE;
   ELASTICITY; HYPERTENSION; DEPRESSION
AB A novel index of finger arterial stiffness (FSI) was tested in terms of the relationship with risk markers for preclinical cardiovascular disease. In addition, we examined if the association between psychosocial factors and FSI was explained by allostatic load markers in 37 healthy young men aged 24.8 +/- 4.0 years. The FSI was devised based on an exponential model of the finger arterial pressure-volume relationship. The allostatic load index (ALI) as a cumulative risk marker was defined by the mean of standard scores for nine variables: resting systolic and diastolic blood pressure, waist/hip ratio, high-density lipoprotein cholesterol (HDL-C), total cholesterol/HDL-C ratio, triglycerides, hemoglobin A1c, insulin resistance, and high sensitivity C-reactive protein (CRP). Partial correlations controlling for age were significant for FSI with HDL-C (r = -.36), CRP (r = .39), ALI (r = .40), unhealthy overall eating habits (r = .34), hostility using the Buss-Perry Aggression Questionnaire (r = .38), and manageability in Sense of Coherence (r = -.38). In conclusion, FSI seems to be associated with vascular proinflammation as well as with overall physiological dysregulation and allostatic load. These associations were moderated by eating lifestyle and psychosocial stress.
C1 [Tanaka, Gohichi] Sapporo Med Univ, Dept Psychol, Ctr Med Educ, Chuo Ku, Sapporo, Hokkaido 0608556, Japan.
   [Matsumura, Kenta] Natl Ctr Neurol & Psychiat, Tokyo, Japan.
   [Ogasawara, Haruko] Hokkaido Univ, Sapporo, Hokkaido 060, Japan.
C3 Sapporo Medical University; National Center for Neurology & Psychiatry -
   Japan; Hokkaido University
RP Tanaka, G (corresponding author), Sapporo Med Univ, Dept Psychol, Ctr Med Educ, Chuo Ku, South 1,West 17, Sapporo, Hokkaido 0608556, Japan.
EM gtanaka@sapmed.ac.jp
RI Tanaka, Gohichi/N-3016-2019; Matsumura, Kenta/ABH-9288-2020
OI Matsumura, Kenta/0000-0002-4271-1543
FU Grants-in-Aid for Scientific Research [22570225, 21300252] Funding
   Source: KAKEN
CR Ando A, 1999, JPN J PSYCHOL, V70, P384, DOI 10.4992/jjpsy.70.384
   Antonovsky A., 1987, J NERV MENT DIS, V177, P439
   Blackburn R, 2001, ARTERIOSCL THROM VAS, V21, P1962, DOI 10.1161/hq1201.099433
   Cernes R, 2008, ADV CARDIOL, V45, P65, DOI 10.1159/000115188
   Cohn JN, 2005, HYPERTENSION, V46, P217, DOI 10.1161/01.HYP.0000165686.50890.c3
   Cook DG, 2000, ATHEROSCLEROSIS, V149, P139, DOI 10.1016/S0021-9150(99)00312-3
   Curtin F, 1998, BIOL PSYCHIAT, V44, P775, DOI 10.1016/S0006-3223(98)00043-2
   Duprez DA, 2005, J HUM HYPERTENS, V19, P515, DOI 10.1038/sj.jhh.1001860
   Edwards KL, 1998, AM J EPIDEMIOL, V147, P441, DOI 10.1093/oxfordjournals.aje.a009469
   Fichtlscherer S, 2000, CIRCULATION, V102, P1000, DOI 10.1161/01.CIR.102.9.1000
   Goodman E, 2005, PSYCHOSOM MED, V67, P9, DOI 10.1097/01.psy.0000149254.36133.1a
   Gray RS, 1998, AM J EPIDEMIOL, V148, P869
   Hildrum B, 2008, BRIT J PSYCHIAT, V193, P108, DOI 10.1192/bjp.bp.107.045013
   Hildrum B, 2007, J EPIDEMIOL COMMUN H, V61, P53, DOI 10.1136/jech.2005.044966
   Iwahashi S., 2002, Japanese Journal of Psychosomatic Medicine, V42, P459, DOI DOI 10.15064/JJPM.42.7_459
   JULIUS S, 1991, J HYPERTENS, V9, P983, DOI 10.1097/00004872-199111000-00001
   Kampus P, 2008, PHYSIOL MEAS, V29, P429, DOI 10.1088/0967-3334/29/4/001
   Korte SM, 2005, NEUROSCI BIOBEHAV R, V29, P3, DOI 10.1016/j.neubiorev.2004.08.009
   Kullo IJ, 2005, AM J HYPERTENS, V18, P1123, DOI 10.1016/j.amjhyper.2005.03.730
   Kumari M, 2004, ANN EPIDEMIOL, V14, P250, DOI 10.1016/j.annepidem.2003.09.011
   Kyle UG, 2004, CLIN NUTR, V23, P1226, DOI 10.1016/j.clnu.2004.06.004
   Laurent S, 2006, EUR HEART J, V27, P2588, DOI 10.1093/eurheartj/ehl254
   Li W, 2007, STRESS HEALTH, V23, P257, DOI 10.1002/smi.1145
   Lockhart CJ, 2009, CLIN SCI, V116, P175, DOI 10.1042/CS20080069
   Maruyama K, 2008, BMJ-BRIT MED J, V337, DOI 10.1136/bmj.a2002
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Matthews KA, 2005, AM HEART J, V149, P1066, DOI 10.1016/j.ahj.2004.08.027
   McEwen BS, 1999, ANN NY ACAD SCI, V896, P30, DOI 10.1111/j.1749-6632.1999.tb08103.x
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   Nakagawa S, 2004, BEHAV ECOL, V15, P1044, DOI 10.1093/beheco/arh107
   Nasermoaddeli A, 2006, PSYCHOSOM MED, V68, P58, DOI 10.1097/01.psy.0000195882.00407.05
   Otsuka R, 2008, PREV MED, V46, P154, DOI 10.1016/j.ypmed.2007.07.031
   Pearson TA, 2003, CIRCULATION, V107, P499, DOI 10.1161/01.CIR.0000052939.59093.45
   Peralta CA, 2009, AM J EPIDEMIOL, V169, P740, DOI 10.1093/aje/kwn392
   Reaven GM, 1996, NEW ENGL J MED, V334, P374, DOI 10.1056/NEJM199602083340607
   Sawada Y, 2001, INT J PSYCHOPHYSIOL, V41, P1, DOI 10.1016/S0167-8760(00)00162-8
   Schneiderman N., 1989, HDB RES METHODS BEHA, P349
   Seeman TE, 1997, ARCH INTERN MED, V157, P2259
   Seeman TE, 2002, PSYCHOSOM MED, V64, P395, DOI 10.1097/00006842-200205000-00004
   Shima S., 1985, PSYCHIATRY, V27, P717, DOI DOI 10.11477/MF.1405203967
   SHIMAI S, 2004, JAPANESE J PUBLIC HL, V51, P845
   SHIMAZU H, 1986, IEEE T BIO-MED ENG, V33, P795, DOI 10.1109/TBME.1986.325906
   Shinji S., 2002, Jpn J Health Psychol, V15, P59, DOI [DOI 10.11560/JAHP.15.1_59, 10.11560/jahp.15.1_59, DOI 10.11560/JAHP.15.159]
   Shirai K, 2006, J ATHEROSCLER THROMB, V13, P101, DOI 10.5551/jat.13.101
   Shroff GR, 2009, J HUM HYPERTENS, V23, P783, DOI 10.1038/jhh.2009.17
   Spieker LE, 2002, CIRCULATION, V105, P1399, DOI 10.1161/01.CIR.0000013424.28206.8F
   Suarez EC, 2004, PSYCHOSOM MED, V66, P684, DOI 10.1097/01.psy.0000138281.73634.67
   Suarez EC, 1999, PSYCHOSOM MED, V61, P273, DOI 10.1097/00006842-199905000-00004
   Tanaka G, 2002, EUR J APPL PHYSIOL, V87, P562, DOI 10.1007/s00421-002-0665-6
   Tanaka G, 2005, ADV PSY RES, V34, P91
   TANAKA G, 2009, P 73 ANN CONV JAP PS, V516
   TAYAMA J, 2008, JAPANESE J PSYCHOSOM, V48, P217
   Tomiyama H, 2005, HYPERTENSION, V45, P997, DOI 10.1161/01.HYP.0000165018.63523.8a
   Uurtuya S, 2009, J MED ULTRASON, V36, P129, DOI 10.1007/s10396-009-0217-3
   Van Bortel LM, 2002, AM J HYPERTENS, V15, P445, DOI 10.1016/S0895-7061(01)02326-3
   Visser M, 1999, JAMA-J AM MED ASSOC, V282, P2131, DOI 10.1001/jama.282.22.2131
   Vlachopoulos C, 2006, HEART, V92, P1544, DOI 10.1136/hrt.2005.067025
   Westhoff TH, 2007, J HYPERTENS, V25, P571, DOI 10.1097/HJH.0b013e3280148301
   Woodman RJ, 2005, AM J HYPERTENS, V18, P249, DOI 10.1016/j.amjhyper.2004.08.038
   Yamazaki Y., 1999, QUALITY NURSING, V5, P825
   Yasmin, 2004, ARTERIOSCL THROM VAS, V24, P969, DOI 10.1161/01.ATV.zhq0504.0173
   Ye XW, 2007, J AM COLL CARDIOL, V49, P1798, DOI 10.1016/j.jacc.2007.01.065
   Zhang JP, 2006, PSYCHOSOM MED, V68, P718, DOI 10.1097/01.psy.0000228343.89466.11
NR 63
TC 3
Z9 7
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-5368
EI 1468-5884
J9 JPN PSYCHOL RES
JI Jpn. Psychol. Res.
PD MAY
PY 2011
VL 53
IS 2
BP 140
EP 154
DI 10.1111/j.1468-5884.2011.00461.x
PG 15
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA 762CE
UT WOS:000290449100005
OA Bronze
DA 2025-06-11
ER

PT J
AU Skroza, N
   Proietti, I
   Bernardini, N
   La Viola, G
   Nicolucci, F
   Pampena, R
   Tolino, E
   Zuber, S
   Mancini, MT
   Soccodato, V
   Balduzzi, V
   Potenza, C
AF Skroza, N.
   Proietti, I.
   Bernardini, N.
   La Viola, G.
   Nicolucci, F.
   Pampena, R.
   Tolino, E.
   Zuber, S.
   Mancini, M. T.
   Soccodato, V.
   Balduzzi, V.
   Potenza, C.
TI Efficacy of food supplement to improve metabolic syndrome parameters in
   patients affected by moderate to severe psoriasis during anti-TNFα
   treatment
SO GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
LA English
DT Article
DE Psoriasis; Metabolic syndrome X; Oxidative stress
AB Aim. Psoriasis is a systemic inflammatory immune-mediated skin disease. Recently a relationship with metabolic syndrome in terms of psoriasis severity and response to therapy was observed.
   Methods. We performed an open-label randomized controlled study to evaluate the role of a nutraceutical containing Q10 coenzyme, Krill-oil, lipoic acid, resveratrol, Vitis vinifera seed oil, vitamin E and selenium in addition to etanercept therapy for patients affected by psoriasis and metabolic syndrome. Forty patients were enrolled and divided into two arms, one receiving only etanercept, one other receiving also the neutraceutical. After a period of 3 months (T1) a second evaluation of the considered parameters was performed.
   Results. At T1 statistically significant differences were detected in HDL cholesterol and triglycerides values both comparing the two arms and in the nutraceutical arm.
   Conclusion. Our results show that the dietary addiction of the nutraceutical to the etanercept therapy in patients affected by both psoriasis and metabolic syndrome could help to restore the normal lipid profile.
C1 [Skroza, N.; Proietti, I.; Bernardini, N.; La Viola, G.; Nicolucci, F.; Pampena, R.; Tolino, E.; Zuber, S.; Mancini, M. T.; Soccodato, V.; Balduzzi, V.; Potenza, C.] Sapienza Univ Rome, Dept Dermatol Daniele Innocenzi, Rome, Italy.
C3 Sapienza University Rome
RP Potenza, C (corresponding author), Sapienza Univ Rome, Dept Dermatol Daniele Innocenzi, Via Firenze, I-04019 Latina, Italy.
EM concetta.potenza@uniroma1.it
RI proietti, ilaria/AAL-9155-2020; Potenza, Concetta/F-4198-2011; skroza,
   nevena/F-3931-2011; Pampena, Riccardo/D-3358-2016
OI Tolino, Ersilia/0000-0001-7861-9338; Potenza,
   Concetta/0000-0002-6300-8697; Proietti, Ilaria/0000-0003-3795-3190;
   Pampena, Riccardo/0000-0002-7699-879X
CR Channual J, 2009, DERMATOL THER, V22, P61, DOI 10.1111/j.1529-8019.2008.01217.x
   Gelfand JM, 2006, JAMA-J AM MED ASSOC, V296, P1735, DOI 10.1001/jama.296.14.1735
   Gelfand JM, 2012, J RHEUMATOL, V39, P24, DOI 10.3899/jrheum.120237
   Kadam DP, 2010, INDIAN J CLIN BIOCHE, V25, P388, DOI 10.1007/s12291-010-0043-9
   Kharaeva Z, 2009, NUTRITION, V25, P295, DOI 10.1016/j.nut.2008.08.015
   Linder D, 2012, J EUR ACAD DERMATOL, V26, P1163, DOI 10.1111/j.1468-3083.2011.04192.x
   Mrowietz U, 2010, J AM ACAD DERMATOL, V62, pAB123
   Potenza C, 2010, PLAQUE PSORIASIS ANA, V1, P1
   Serwin AB, 2009, FREE RADIC BIOL MED, V47, P891
   Shay KP, 2003, NUTRITION, V19, P301
NR 10
TC 8
Z9 9
U1 0
U2 9
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0392-0488
EI 1827-1820
J9 GIORN ITAL DERMAT V
JI G. Ital. Dermatol. Venereol.
PD DEC
PY 2013
VL 148
IS 6
BP 661
EP 665
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA AC0NR
UT WOS:000332192500014
PM 24442048
DA 2025-06-11
ER

PT J
AU Black, CN
   Bot, M
   Scheffer, PG
   Penninx, BWJH
AF Black, Catherine N.
   Bot, Mariska
   Scheffer, Peter G.
   Penninx, Brenda W. J. H.
TI Sociodemographic and Lifestyle Determinants of Plasma Oxidative Stress
   Markers 8-OHdG and F2-Isoprostanes and Associations with Metabolic
   Syndrome
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID BODY-MASS INDEX; DNA-DAMAGE; RISK-FACTORS; CARDIOVASCULAR-DISEASE;
   PHYSICAL-ACTIVITY; BIOMARKERS; F-2-ISOPROSTANES; SMOKING; DEPRESSION;
   EXCRETION
AB Background. Oxidative stress is increasingly important in health research. Therefore, it is necessary to understand which factors determine basal oxidative stress. This study examines the associations of various determinants with markers of oxidative DNA and lipid damage: 8-hydroxy-2'-deoxyguanosine (8-OHdG) and F2-isoprostanes. Methods. Data are from the Netherlands Study of Depression and Anxiety; 1117 subjects (18-65 years) without a current psychiatric diagnosis. Multivariable regression analyses were conducted with plasma levels of 8-OHdG and F2-isoprostanes (measured by LC/MS-MS) including sociodemographic, lifestyle, and sampling variables. Associations with metabolic syndrome (MetS) and chronic disease were examined. Results. 8-OHdG and F2-isoprostanes were weakly correlated (r = 0.06, p = 0.045). Both were positively associated with age and cotinine (cigarette exposure); 8-OHdG was lower in females and after longer sample storage. F2-isoprostanes were higher in females, alcohol users, and in samples collected in spring and lower in supplement users and those with more education. Both markers were lower in fasting subjects. F2-isoprostanes, not 8-OHdG, were positively associated with MetS. Conclusion. The weak correlation between 8-OHdG and F2-isoprostanes suggests they reflect specific aspects of oxidative stress. Both markers are associated with a range of sociodemographic, lifestyle, and sampling determinants which should be considered in future research. F2-isoprostanes are associated with MetS.
C1 [Black, Catherine N.; Bot, Mariska; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam Med Ctr, Dept Psychiat, POB 74077, NL-1070 BB Amsterdam, Netherlands.
   [Black, Catherine N.; Bot, Mariska; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, POB 74077, NL-1070 BB Amsterdam, Netherlands.
   [Black, Catherine N.; Bot, Mariska; Penninx, Brenda W. J. H.] GGZ inGeest, POB 74077, NL-1070 BB Amsterdam, Netherlands.
   [Scheffer, Peter G.] Vrije Univ Amsterdam Med Ctr, Dept Clin Chem, NL-1070 BB Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Vrije
   Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Vrije Universiteit
   Amsterdam; VU UNIVERSITY MEDICAL CENTER
RP Black, CN (corresponding author), Vrije Univ Amsterdam Med Ctr, Dept Psychiat, POB 74077, NL-1070 BB Amsterdam, Netherlands.; Black, CN (corresponding author), Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, POB 74077, NL-1070 BB Amsterdam, Netherlands.; Black, CN (corresponding author), GGZ inGeest, POB 74077, NL-1070 BB Amsterdam, Netherlands.
EM c.black@ggzingeest.nl
RI Penninx, Brenda/S-7627-2017
FU NWO-VICI Grant [91811602]; Geestkracht program of the Netherlands
   Organization for Health Research and Development (Zon-Mw) [10-000-1002];
   VU University Medical Center; Leiden University Medical Center;
   University Medical Center Groningen
FX The authors would like to thank Jan Nouta and acknowledge his
   contribution to the determining of plasma 8-OHdG levels in this study.
   Catherine N. Black and Brenda W. J. H. Penninx are supported by a
   NWO-VICI Grant (no. 91811602). The infrastructure for the NESDA study
   (http://www.nesda.nl/) has been funded through the Geestkracht program
   of the Netherlands Organization for Health Research and Development
   (Zon-Mw, Grant no. 10-000-1002) and participating universities (VU
   University Medical Center, Leiden University Medical Center, and
   University Medical Center Groningen).
CR Alkazemi D, 2012, FREE RADICAL RES, V46, P1258, DOI 10.3109/10715762.2012.702900
   Barden A, 2007, FREE RADICAL BIO MED, V42, P1730, DOI 10.1016/j.freeradbiomed.2007.03.004
   Basu S, 2001, ANN RHEUM DIS, V60, P627, DOI 10.1136/ard.60.6.627
   Basu S, 2009, FREE RADICAL RES, V43, P85, DOI 10.1080/10715760802610851
   Black CN, 2015, PSYCHONEUROENDOCRINO, V51, P164, DOI 10.1016/j.psyneuen.2014.09.025
   Block G, 2002, AM J EPIDEMIOL, V156, P274, DOI 10.1093/aje/kwf029
   Broedbaek K, 2011, FREE RADICAL BIO MED, V50, P1488, DOI 10.1016/j.freeradbiomed.2011.02.017
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   Dalle-Donne I, 2006, CLIN CHEM, V52, P601, DOI 10.1373/clinchem.2005.061408
   Davies SS, 2011, FREE RADICAL BIO MED, V50, P559, DOI 10.1016/j.freeradbiomed.2010.11.023
   Elahi MM, 2009, OXID MED CELL LONGEV, V2, P259, DOI 10.4161/oxim.2.5.9441
   England T, 2000, FREE RADICAL RES, V32, P355, DOI 10.1080/10715760000300351
   Fujita K, 2006, CIRC J, V70, P1437, DOI 10.1253/circj.70.1437
   Gorber SC, 2009, NICOTINE TOB RES, V11, P12, DOI 10.1093/ntr/ntn010
   Gross M, 2005, CLIN CHEM, V51, P125, DOI 10.1373/clinchem.2004.037630
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Harman SM, 2003, FREE RADICAL BIO MED, V35, P1301, DOI 10.1016/j.freeradbiomed.2003.07.003
   Il'yasova D, 2012, OBESITY, V20, P1915, DOI 10.1038/oby.2011.292
   Irie M, 2005, CANCER SCI, V96, P600, DOI 10.1111/j.1349-7006.2005.00083.x
   Iwanaga S, 2014, OBES RES CLIN PRACT, V8, pE271, DOI 10.1016/j.orcp.2013.01.003
   Jacob KD, 2013, MECH AGEING DEV, V134, P139, DOI 10.1016/j.mad.2013.02.008
   Janicki-Deverts D, 2009, PSYCHOSOM MED, V71, P541, DOI 10.1097/PSY.0b013e31819e7526
   KASAI H, 1984, NUCLEIC ACIDS RES, V12, P2127, DOI 10.1093/nar/12.4.2127
   Kasai H, 2001, JPN J CANCER RES, V92, P9, DOI 10.1111/j.1349-7006.2001.tb01041.x
   Kaya MC, 2012, ARCH MED RES, V43, P294, DOI 10.1016/j.arcmed.2012.05.006
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Kroese LJ, 2014, CURR ATHEROSCLER REP, V16, DOI 10.1007/s11883-014-0452-y
   LOFT S, 1992, CARCINOGENESIS, V13, P2241, DOI 10.1093/carcin/13.12.2241
   Martinet W, 2002, CIRCULATION, V106, P927, DOI 10.1161/01.CIR.0000026393.47805.21
   Meagher EA, 1999, J CLIN INVEST, V104, P805, DOI 10.1172/JCI5584
   Miyamoto M, 2010, MED PRIN PRACT, V20, P187, DOI 10.1159/000319774
   Mizoue T, 2007, CANCER SCI, V98, P1254, DOI 10.1111/j.1349-7006.2007.00511.x
   Muzembo BA, 2012, GERIATR GERONTOL INT, V12, P547, DOI 10.1111/j.1447-0594.2011.00793.x
   Niki E, 2014, BBA-GEN SUBJECTS, V1840, P809, DOI 10.1016/j.bbagen.2013.03.020
   Penninx BWJH, 2008, INT J METH PSYCH RES, V17, P121, DOI 10.1002/mpr.256
   Pilger A, 2006, INT ARCH OCC ENV HEA, V80, P1, DOI 10.1007/s00420-006-0106-7
   Sakano N, 2009, J CLIN BIOCHEM NUTR, V44, P185, DOI 10.3164/jcbn.08-252
   Seet RCS, 2011, FREE RADICAL BIO MED, V50, P1787, DOI 10.1016/j.freeradbiomed.2011.03.019
   Seven A, 2008, CLIN BIOCHEM, V41, P538, DOI 10.1016/j.clinbiochem.2008.01.029
   Shanely RA, 2013, SCAND J MED SCI SPOR, V23, P215, DOI 10.1111/j.1600-0838.2011.01373.x
   Sjogren P, 2005, ARTERIOSCL THROM VAS, V25, P2580, DOI 10.1161/01.ATV.0000190675.08857.3d
   Tamae K, 2009, CANCER SCI, V100, P715, DOI 10.1111/j.1349-7006.2009.01088.x
   Valavanidis A, 2009, J ENVIRON SCI HEAL C, V27, P120, DOI 10.1080/10590500902885684
   Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
   Warolin J, 2014, PEDIATR OBES, V9, P43, DOI 10.1111/j.2047-6310.2012.00135.x
   Watters JL, 2009, BIOMARKERS, V14, P587, DOI 10.3109/13547500903183954
   Woodward M, 2009, CLIN SCI, V116, P53, DOI 10.1042/CS20070404
   World Health Organization, 2010, AN THER CHEM ATC CLA
   Wu SH, 2014, J WOMENS HEALTH, V23, P159, DOI 10.1089/jwh.2013.4456
   Zhang ZJ, 2013, ANN CLIN BIOCHEM, V50, P108, DOI 10.1258/acb.2012.011263
NR 50
TC 56
Z9 60
U1 0
U2 14
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2016
VL 2016
AR 7530820
DI 10.1155/2016/7530820
PG 10
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cell Biology
GA DK9YK
UT WOS:000375287900001
PM 27006748
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Lamers, F
   de Jonge, P
   Nolen, WA
   Smit, JH
   Zitman, FG
   Beekman, ATF
   Penninx, BWJH
AF Lamers, Femke
   de Jonge, Peter
   Nolen, Willem A.
   Smit, Johannes H.
   Zitman, Frans G.
   Beekman, Aartjan T. F.
   Penninx, Brenda W. J. H.
TI Identifying Depressive Subtypes in a Large Cohort Study: Results From
   the Netherlands Study of Depression and Anxiety (NESDA)
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID ATYPICAL DEPRESSION; MAJOR DEPRESSION; SYMPTOMATOLOGY IDS; MOOD
   DISORDERS; DSM-V; VALIDATION; SYMPTOMS; CLASSIFICATION; COMORBIDITY;
   HYPOTHESIS
AB Objective: The heterogeneity of depression in the current classification system remains a point of discussion in the psychiatric field, despite previous efforts to subclassify depressive disorders. Data-driven techniques may help to come to a more empirically based classification. This study aimed to identify depressive subtypes within a large cohort of subjects with depression.
   Method: Baseline data from 818 persons with a DSM-IV diagnosis of current major depressive disorder or minor depression who participated in the Netherlands Study of Depression and Anxiety were used. Respondents were recruited in the community, in primary care, and in specialized mental health care from September 2004 through February 2007. Latent classes were derived from latent class analysis using 16 depressive symptoms from the Composite International Diagnostic Interview and the Inventory of Depressive Symptomatology. Classes were characterized using demographic, clinical psychiatric, psychosocial, and physical health descriptors.
   Results: Three classes were identified: a severe melancholic class (prevalence, 46.3%), a severe atypical class (prevalence, 24.6%), and a class of moderate severity (prevalence, 29.1%). Both severe classes were characterized by more neuroticism (melancholic OR=1.05 [95% CI, 1.01-1.10]; atypical OR=1.07 [95% Cl, 1.03-1.12]), more disability (melancholic OR=1.07 [95% Cl, 1.05-1.09]; atypical OR=1.06 [95% CI, 1.04-1.07]), and less extraversion (melancholic OR=0.95 [95% CI, 0.92-0.99]; atypical OR=0.95 [95% CI, 0.92-0.99] than the moderate class. Comparing the melancholic class with the atypical class revealed that the melancholic class had more smokers (atypical OR=0.57 [95% CI, 0.39-0.84]) and more childhood trauma (atypical OR=0.86 [95% CI, 0.74-1.00]), whereas the atypical class had more women (atypical OR=1.52 [95% CI, 0.99-2.32]), a higher body mass index (atypical OR=1.13 [95% CI, 1.09-1.17]), and more metabolic syndrome (atypical OR=2.17 [95% CI, 1.38-3.42]).
   Conclusions: Both depression severity (moderate vs severe) and the nature of depressive symptoms (melancholic vs atypical) were found to be important differentiators between subtypes. Higher endorsement rates of somatic symptoms and more metabolic syndrome in the atypical class suggest the involvement of a metabolic component. J Clin Psychiatry 2010;71(12):1582-1589 (C) Copyright 2010 Physicians Postgraduate Press, Inc.
C1 [Lamers, Femke; Smit, Johannes H.; Beekman, Aartjan T. F.; Penninx, Brenda W. J. H.] VU Univ Med Ctr Amsterdam, Dept Psychiat, NL-1081 HL Amsterdam, Netherlands.
   [Lamers, Femke; Smit, Johannes H.; Beekman, Aartjan T. F.; Penninx, Brenda W. J. H.] VU Univ Med Ctr Amsterdam, EMGO Inst Hlth & Care Res, NL-1081 HL Amsterdam, Netherlands.
   [de Jonge, Peter; Nolen, Willem A.; Penninx, Brenda W. J. H.] Univ Groningen, Dept Psychiat, NL-9700 AB Groningen, Netherlands.
   [de Jonge, Peter] Univ Groningen, Dept Internal Med, Univ Med Ctr Groningen, NL-9700 AB Groningen, Netherlands.
   [de Jonge, Peter] Tilburg Univ, Ctr Res Psychol Somat Dis, Dept Med Psychol, NL-5000 LE Tilburg, Netherlands.
   [Zitman, Frans G.; Penninx, Brenda W. J. H.] Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.
C3 Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Vrije
   Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; University of
   Groningen; University of Groningen; Tilburg University; Leiden
   University - Excl LUMC; Leiden University; Leiden University Medical
   Center (LUMC)
RP Lamers, F (corresponding author), VU Univ Med Ctr Amsterdam, Dept Psychiat, AJ Ernststr 887, NL-1081 HL Amsterdam, Netherlands.
EM f.lamers@vumc.nl
RI Lamers, Femke/G-5161-2012; Nolen, Willem/E-9006-2014; Zitman,
   Frans/E-7705-2010; Penninx, Brenda/S-7627-2017; Beekman, Aartjan
   T./LUZ-6919-2024; Sundström, Johan/IAP-6197-2023; de Jonge,
   Peter/L-6395-2013
OI de Jonge, Peter/0000-0002-0866-6929; Lamers, Femke/0000-0003-4344-5766
FU Netherlands Organization for Health Research and Development; European
   Union; Stanley Medical Research Institute; AstraZeneca; Eli Lilly;
   GlaxoSmithKline; Wyeth; Pfizer; Servier; Netherlands Organization for
   Health Research and Development (ZonMw) [10-000-1002]; VU University
   Medical Center; GGZ inGeest; Arkin; Leiden University Medical Center;
   GGZ Rivierduinen; University Medical Center Groningen; Lentis; GGZ
   Friesland; GGZ Drenthe; IQ Healthcare; Netherlands Institute for Health
   Services Research (NIVEL); Netherlands Institute of Mental Health and
   Addiction (Trimbos)
FX Dr Nolen has received grants from the Netherlands Organization for
   Health Research and Development, European Union, Stanley Medical
   Research Institute, AstraZeneca, Eli Lilly, GlaxoSmithKline, and Wyeth;
   has received honoraria or speaker fees from AstraZeneca, Eli Lilly,
   Pfizer, Servier, and Wyeth; and has been an advisory board member for
   AstraZeneca, Cyberonics, Pfizer, and Servier. Drs Lamers, de Jonge,
   Smit, Zitman, Beekman, and Penninx report no financial or other
   relationships relevant to the subject of this article.The infrastructure
   for the Netherlands Study of Depression and Anxiety (NESDA)
   (www.nesda.nl) is funded through the Geestkracht program of the
   Netherlands Organization for Health Research and Development (ZonMw,
   grant number 10-000-1002) and is supported by participating universities
   and mental health care organizations: VU University Medical Center, GGZ
   inGeest, Arkin, Leiden University Medical Center, GGZ Rivierduinen,
   University Medical Center Groningen, Lentis, GGZ Friesland, GGZ Drenthe,
   IQ Healthcare, Netherlands Institute for Health Services Research
   (NIVEL), and the Netherlands Institute of Mental Health and Addiction
   (Trimbos).
CR Angst J, 2006, EUR ARCH PSY CLIN N, V256, P44, DOI 10.1007/s00406-005-0600-z
   Angst J, 2002, J AFFECT DISORDERS, V72, P125, DOI 10.1016/S0165-0327(02)00169-6
   [Anonymous], HDB PAIN ASSESSMENT
   [Anonymous], 1997, COMP INT DIAGN INT C
   [Anonymous], 1988, STAT POWER ANAL BEHA
   Antonijevic IA, 2006, PSYCHONEUROENDOCRINO, V31, P1, DOI 10.1016/j.psyneuen.2005.04.004
   BRUGHA T, 1985, PSYCHOL MED, V15, P189, DOI 10.1017/S003329170002105X
   Chwastiak LA, 2003, J CLIN EPIDEMIOL, V56, P507, DOI 10.1016/S0895-4356(03)00051-9
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   COSTA PT, 1995, J PERS ASSESS, V64, P21, DOI 10.1207/s15327752jpa6401_2
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   de Graaf R, 2002, AM J PSYCHIAT, V159, P620, DOI 10.1176/appi.ajp.159.4.620
   De Jonge P, 2007, PSYCHOSOM MED, V69, P735, DOI 10.1097/PSY.0b013e31815743ca
   Fyer AJ, 1999, AM J MED GENET, V88, P173, DOI 10.1002/(SICI)1096-8628(19990416)88:2<173::AID-AJMG15>3.3.CO;2-R
   Grigoriadis Sophie, 2007, Ann Clin Psychiatry, V19, P247, DOI 10.1080/10401230701653294
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Hagenaars J. A., 2002, APPL LATENT CLASS AN, DOI 10.1017/CBO9780511499531
   Halbreich U, 2006, PSYCHONEUROENDOCRINO, V31, P16, DOI 10.1016/j.psyneuen.2005.08.004
   Halbreich U, 2007, J AFFECT DISORDERS, V102, P245, DOI 10.1016/j.jad.2006.09.023
   Harkness KL, 2002, AM J PSYCHIAT, V159, P387, DOI 10.1176/appi.ajp.159.3.387
   Hirschfeld RMA, 2000, AM J PSYCHIAT, V157, P1873, DOI 10.1176/appi.ajp.157.11.1873
   Holsboer F, 2000, NEUROPSYCHOPHARMACOL, V23, P477, DOI 10.1016/S0893-133X(00)00159-7
   Joyce PR, 2008, AUST NZ J PSYCHIAT, V42, P851, DOI 10.1080/00048670802363667
   Katon WJ, 2003, BIOL PSYCHIAT, V54, P216, DOI 10.1016/S0006-3223(03)00273-7
   Kendler KS, 1996, ARCH GEN PSYCHIAT, V53, P391
   Klein DN, 2008, J ABNORM PSYCHOL, V117, P552, DOI 10.1037/0021-843X.117.3.552
   Lerman C, 1998, HEALTH PSYCHOL, V17, P56, DOI 10.1037/0278-6133.17.1.56
   Lu XY, 2007, CURR OPIN PHARMACOL, V7, P648, DOI 10.1016/j.coph.2007.10.010
   LYKETSOS CG, 1994, INT J METHOD PSYCH, V4, P143
   McIntyre Roger S, 2007, Ann Clin Psychiatry, V19, P257, DOI 10.1080/10401230701653377
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Mosovich SA, 2008, INT J CLIN PRACT, V62, P423, DOI 10.1111/j.1742-1241.2007.01640.x
   Muthen L.K., 2018, Mplus user's guide, V8th ed.
   Nemeroff CB, 2004, J CLIN PSYCHIAT, V65, P18
   Novick JS, 2005, J CLIN PSYCHIAT, V66, P1002, DOI 10.4088/JCP.v66n0807
   Nylund KL, 2007, STRUCT EQU MODELING, V14, P535, DOI 10.1080/10705510701575396
   PARKER G, 1987, J AFFECT DISORDERS, V13, P75, DOI 10.1016/0165-0327(87)90076-0
   Parker G, 2002, AM J PSYCHIAT, V159, P1470, DOI 10.1176/appi.ajp.159.9.1470
   Parker G, 1997, PSYCHIAT RES, V73, P57, DOI 10.1016/S0165-1781(97)00113-3
   Penninx BWJH, 2008, INT J METH PSYCH RES, V17, P121, DOI 10.1002/mpr.256
   Posternak MA, 2002, ARCH GEN PSYCHIAT, V59, P70, DOI 10.1001/archpsyc.59.1.70
   Raison CL, 2006, TRENDS IMMUNOL, V27, P24, DOI 10.1016/j.it.2005.11.006
   RUSH AJ, 1986, PSYCHIAT RES, V18, P65
   Rush AJ, 1996, PSYCHOL MED, V26, P477, DOI 10.1017/S0033291700035558
   Sullivan PF, 2002, J AFFECT DISORDERS, V68, P273, DOI 10.1016/S0165-0327(00)00364-5
   Sullivan PF, 1998, AM J PSYCHIAT, V155, P1398, DOI 10.1176/ajp.155.10.1398
   Thase ME, 2007, J CLIN PSYCHIAT, V68, P11
   van Praag HM, 2008, EUR ARCH PSY CLIN N, V258, P29, DOI 10.1007/s00406-008-2006-1
   WEST ED, 1959, BRIT MED J, V1, P1491, DOI 10.1136/bmj.1.5136.1491
NR 49
TC 218
Z9 232
U1 1
U2 65
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD DEC
PY 2010
VL 71
IS 12
BP 1582
EP 1589
DI 10.4088/JCP.09m05398blu
PG 8
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 707OO
UT WOS:000286296100003
PM 20673552
DA 2025-06-11
ER

PT J
AU Wingo, AP
   Gibson, G
AF Wingo, Aliza P.
   Gibson, Greg
TI Blood gene expression profiles suggest altered immune function
   associated with symptoms of generalized anxiety disorder
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Anxiety; Generalized anxiety disorder; Gene expression; Genome-wide
   differential gene expression; Immune function; Modules of co-regulated
   transcripts
ID CORONARY-HEART-DISEASE; BODY-MASS INDEX; PSYCHOLOGICAL STRESS;
   ANTIBODY-RESPONSE; INFLUENZA; VACCINATION; MODULATION; GENOMICS; RISK
AB Prospective epidemiological studies found that generalized anxiety disorder (GAD) can impair immune function and increase risk for cardiovascular disease or events. Mechanisms underlying the physiological reverberations of anxiety, however, are still elusive. Hence, we aimed to investigate molecular processes mediating effects of anxiety on physical health using blood gene expression profiles of 336 community participants (157 anxious and 179 control). We examined genome-wide differential gene expression in anxiety, as well as associations between nine major modules of co-regulated transcripts in blood gene expression and anxiety. No significant differential expression was observed in women, but 631 genes were differentially expressed between anxious and control men at the false discovery rate of 0.1 after controlling for age, body mass index, race, and batch effect. Gene set enrichment analysis (GSEA) revealed that genes with altered expression levels in anxious men were involved in response of various immune cells to vaccination and to acute viral and bacterial infection, and in a metabolic network affecting traits of metabolic syndrome. Further, we found one set of 260 co-regulated genes to be significantly associated with anxiety in men after controlling for the relevant covariates, and demonstrate its equivalence to a component of the stress-related conserved transcriptional response to adversity profile. Taken together, our results suggest potential molecular pathways that can explain negative effects of GAD observed in epidemiological studies. Remarkably, even mild anxiety, which most of our participants had, was associated with observable changes in immune-related gene expression levels. Our findings generate hypotheses and provide incremental insights into molecular mechanisms mediating negative physiological effects of GAD. Published by Elsevier Inc.
C1 [Wingo, Aliza P.] Atlanta VA Med Ctr, Decatur, GA 30033 USA.
   [Wingo, Aliza P.] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA.
   [Gibson, Greg] Georgia Inst Technol, Ctr Integrat Genom, Sch Biol, Atlanta, GA 30332 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Atlanta VA Health Care System; Atlanta VA Medical Center; Emory
   University; University System of Georgia; Georgia Institute of
   Technology
RP Gibson, G (corresponding author), Georgia Inst Technol, Boggs 34334, Atlanta, GA 30332 USA.
EM greg.gibson@biology.gatech.edu
OI Wingo, Aliza/0000-0002-6360-6726
FU Department of Veterans Affairs Career Development Award [IK2CX000601];
   NARSAD; Georgia Tech Research Institute; NIH [P01GM099568]
FX This study was supported in part by the Department of Veterans Affairs
   Career Development Award number IK2CX000601 and the NARSAD Young
   Investigator Award (to APW). The contents do not represent the views of
   the Department of Veterans Affairs or the United States Government. Gene
   expression data was generated with start-up funds to GG from the Georgia
   Tech Research Institute, and phenotypic data for the CHDWB was generated
   with support from the Emory University School of Medicine. GG is also
   supported by the NIH award P01GM099568 (Project 3).
CR Antonini-Canterin F, 2014, J CARDIOVASC MED, V15, P752, DOI 10.2459/JCM.0000000000000118
   Arranz L, 2007, J PSYCHOSOM RES, V62, P1, DOI 10.1016/j.jpsychores.2006.07.030
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   Borgeraas H, 2014, BMC CARDIOVASC DISOR, V14, DOI 10.1186/1471-2261-14-68
   Burns VE, 2002, PSYCHOSOM MED, V64, P963, DOI 10.1097/01.PSY.0000038936.67401.28
   Chaussabel D, 2008, IMMUNITY, V29, P150, DOI 10.1016/j.immuni.2008.05.012
   Chen YQ, 2008, NATURE, V452, P429, DOI 10.1038/nature06757
   Cohen F, 1999, ARCH INTERN MED, V159, P2430, DOI 10.1001/archinte.159.20.2430
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   COHEN S, 1991, NEW ENGL J MED, V325, P606, DOI 10.1056/NEJM199108293250903
   Cole SW, 2014, PLOS GENET, V10, DOI 10.1371/journal.pgen.1004601
   Cole SW, 2012, P NATL ACAD SCI USA, V109, P20578, DOI 10.1073/pnas.1218253109
   Dimsdale JE, 2010, J AM COLL CARDIOL, V56, P47, DOI 10.1016/j.jacc.2010.04.013
   Ferranti EP, 2013, RES NURS HEALTH, V36, P242, DOI 10.1002/nur.21532
   Fredrickson BL, 2013, P NATL ACAD SCI USA, V110, P13684, DOI 10.1073/pnas.1305419110
   Fulcher JA, 2006, J IMMUNOL, V177, P216, DOI 10.4049/jimmunol.177.1.216
   GLASER R, 1992, PSYCHOSOM MED, V54, P22, DOI 10.1097/00006842-199201000-00005
   Glaser R, 2000, PSYCHOSOM MED, V62, P804, DOI 10.1097/00006842-200011000-00010
   Godbout JP, 2006, J NEUROIMMUNE PHARM, V1, P421, DOI 10.1007/s11481-006-9036-0
   Janszky I, 2010, J AM COLL CARDIOL, V56, P31, DOI 10.1016/j.jacc.2010.03.033
   Jeffrey KL, 2006, NAT IMMUNOL, V7, P274, DOI 10.1038/ni1310
   Kessler RC, 2005, ARCH GEN PSYCHIAT, V62, P593, DOI 10.1001/archpsyc.62.6.593
   Löwe B, 2008, MED CARE, V46, P266, DOI 10.1097/MLR.0b013e318160d093
   Lu Y, 2014, LANCET, V383, P970, DOI 10.1016/S0140-6736(13)61836-X
   Martens EJ, 2010, ARCH GEN PSYCHIAT, V67, P750, DOI 10.1001/archgenpsychiatry.2010.74
   Mecham BH, 2010, BIOINFORMATICS, V26, P1308, DOI 10.1093/bioinformatics/btq118
   Miller GE, 2004, PSYCHOSOM MED, V66, P215, DOI 10.1097/01.psy.0000116718.54414.9e
   Mootha VK, 2003, NAT GENET, V34, P267, DOI 10.1038/ng1180
   Morag M, 1999, J PSYCHIAT RES, V33, P389, DOI 10.1016/S0022-3956(99)00010-2
   Nakaya HI, 2011, NAT IMMUNOL, V12, P786, DOI 10.1038/ni.2067
   Nath Artika Praveeta, 2012, Frontiers in Genetics, V3, P243, DOI 10.3389/fgene.2012.00243
   Palucka K, 2013, CURR OPIN IMMUNOL, V25, P396, DOI 10.1016/j.coi.2013.05.001
   Preininger M, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003362
   Ramilo O, 2007, BLOOD, V109, P2066, DOI 10.1182/blood-2006-02-002477
   Reiner A, 2003, BIOINFORMATICS, V19, P368, DOI 10.1093/bioinformatics/btf877
   Roest AM, 2010, J AM COLL CARDIOL, V56, P38, DOI 10.1016/j.jacc.2010.03.034
   Ruiz MA, 2011, J AFFECT DISORDERS, V128, P277, DOI 10.1016/j.jad.2010.07.010
   Sareen J, 2005, DEPRESS ANXIETY, V21, P193, DOI 10.1002/da.20072
   Spitzer RL, 2006, ARCH INTERN MED, V166, P1092, DOI 10.1001/archinte.166.10.1092
   STONE AA, 1992, BEHAV MED, V18, P115, DOI 10.1080/08964289.1992.9936961
   Subramanian A, 2005, P NATL ACAD SCI USA, V102, P15545, DOI 10.1073/pnas.0506580102
   Torpy Janet M, 2011, JAMA, V305, P522, DOI 10.1001/jama.305.5.522
   Vaccarino V, 2014, PSYCHOSOM MED, V76, P171, DOI 10.1097/PSY.0000000000000045
   Vedhara K, 1999, LANCET, V353, P627, DOI 10.1016/S0140-6736(98)06098-X
   Vogelzangs N, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.27
NR 45
TC 41
Z9 42
U1 2
U2 24
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD JAN
PY 2015
VL 43
BP 184
EP 191
DI 10.1016/j.bbi.2014.09.016
PG 8
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA CQ4RQ
UT WOS:000360592700022
PM 25300922
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Eriksson, MD
   Eriksson, JG
   Kautiainen, H
   Salonen, MK
   Mikkola, TM
   Kajantie, E
   Wasenius, N
   von Bonsdorff, M
   Laine, MK
AF Eriksson, Mia D.
   Eriksson, Johan G.
   Kautiainen, Hannu
   Salonen, Minna K.
   Mikkola, Tuija M.
   Kajantie, Eero
   Wasenius, Niko
   von Bonsdorff, Mikaela
   Laine, Merja K.
TI Advanced glycation end products measured by skin autofluorescence are
   associated with melancholic depressive symptoms - Findings from Helsinki
   Birth Cohort Study
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Advanced glycation end products; Biomarkers; Cohort studies;
   Comorbidity; Depression; Depressive disorder; Inflammation
ID ARTERIAL STIFFNESS; METABOLIC SYNDROME; OXIDATIVE STRESS; MENTAL-HEALTH;
   LIFE-STYLE; POPULATION; DISEASE; RISK; PREVALENCE; DISORDERS
AB Background: Millions of people live with depression and its burden of disease. Depression has an increased comorbidity and mortality that has remained unexplained. Studies have reported connections between advanced glycation end products (AGEs) and various disease processes, including mental health. The present study evaluated associations between AGEs, depressive symptoms, and types of depressive symptoms.
   Methods: From the Helsinki Birth Cohort Study, 815 participants with a mean age of 76 years were recruited for this cross-sectional study. Characteristics regarding self-reported lifestyle and medical history, as well as blood tests were obtained along with responses regarding depressive symptoms according to the Beck Depression Inventory (BDI) and Mental Health Inventory-5. Each participant had their AGE level measured non-invasively with skin autofluorescence (SAF). Statistical analyses looked at relationships between types of depressive symptoms and AGE levels by sex.
   Results: Of women, 27% scored >= 10 on the BDI and 18% of men, respectively. Men had higher crude AGE levels (mean [standard deviation], arbitrary units) (2.49 [0.51]) compared to women (2.33 [0.46]) (p < 0.001). The highest crude AGE levels were found in those with melancholic depressive symptoms (2.61 [0.57]), followed by those with non-melancholic depressive symptoms (2.45 [0.45]) and those with no depressive symptoms (2.38 [0.49]) (p = 0.013). These findings remained significant in the fully adjusted model.
   Conclusions: The current study shows an association between depressive symptoms and higher AGE levels. The association is likely part of a multi-factorial effect, and hence no directionality, causality, or effect can be inferred solely based on the results of this study.
C1 [Eriksson, Mia D.] Helsinki Univ Hosp HUS, Primary Hlth Care Unit, Helsinki, Finland.
   [Eriksson, Mia D.; Eriksson, Johan G.; Kautiainen, Hannu; Salonen, Minna K.; Mikkola, Tuija M.; Wasenius, Niko; von Bonsdorff, Mikaela; Laine, Merja K.] Folkhalsan Res Ctr, Helsinki, Finland.
   [Eriksson, Johan G.; Kautiainen, Hannu; Wasenius, Niko; Laine, Merja K.] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.
   [Eriksson, Johan G.; Kautiainen, Hannu; Wasenius, Niko; Laine, Merja K.] Helsinki Univ Hosp, Helsinki, Finland.
   [Eriksson, Johan G.; Kautiainen, Hannu] Natl Univ Singapore, Dept Obstet & Gynecol, Human Potential Translat Res Programme, Yong Loo Lin Sch Med, Singapore, Singapore.
   [Eriksson, Johan G.; Kautiainen, Hannu] ASTAR, Singapore Inst Clin Sci SICS, Singapore, Singapore.
   [Kautiainen, Hannu] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
   [Salonen, Minna K.; Kajantie, Eero] Finnish Inst Hlth & Welf, Publ Hlth Promot Unit, Dept Publ Hlth Solut, Helsinki, Finland.
   [Mikkola, Tuija M.] Univ Helsinki, Clinicum, Fac Med, Helsinki, Finland.
   [Kajantie, Eero] Oulu Univ Hosp, MRC Oulu, PEDEGO Res Unit, Oulu, Finland.
   [Kajantie, Eero] Univ Oulu, Oulu, Finland.
   [Kajantie, Eero] Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway.
   [von Bonsdorff, Mikaela] Univ Jyvaskyla, Fac Sport & Hlth Sci, Gerontol Res Ctr, Jyvaskyla, Finland.
C3 Folkhalsan Research Center; University of Helsinki; University of
   Helsinki; Helsinki University Central Hospital; National University of
   Singapore; Agency for Science Technology & Research (A*STAR); A*STAR -
   Singapore Institute for Clinical Sciences (SICS); University of Eastern
   Finland; University of Helsinki; University of Oulu; University of Oulu;
   Norwegian University of Science & Technology (NTNU); University of
   Jyvaskyla
RP Eriksson, MD (corresponding author), Helsinki Univ Hosp HUS, Primary Hlth Care Unit, Helsinki, Finland.; Eriksson, MD (corresponding author), Folkhalsan Res Ctr, Helsinki, Finland.
EM mia.eriksson@tcu.edu
RI Wasenius, Niko/AAE-8927-2020; Gibbs, J. Raphael/A-3984-2010; Mikkola,
   Tuija/L-2835-2014; /H-8100-2016; von Bonsdorff, Mikaela/A-5218-2015
OI Eriksson, Mia/0000-0001-8968-8304; Mikkola, Tuija/0000-0003-0885-2788;
   /0000-0002-1848-1514; von Bonsdorff, Mikaela/0000-0001-8530-5230;
   Wasenius, Niko/0000-0002-9007-6660
FU Finska Lakaresallskapet; Finnish Special Governmental Subsidy for Health
   Sciences; Academy of Finland [126775, 127437, 129255, 129306, 129907,
   130326, 134791, 209072, 210595, 213225, 263924, 275074, 315690];
   Samfundet Folkhalsan; Liv och Halsa; EU FP7 [Developmental Origins of
   Healthy Aging (DORIAN)] [278603]; EU H2020-PHC-2014-DynaHealth grant
   [633595]; EU Horizon 2020 Award [733206]; European Commission,
   Horizon2020 award [733280]; Foundation for Cardiovascular Research;
   Foundation for Diabetes Research; Foundation for Pediatric Research;
   Novo Nordisk Foundation; Signe and Ane Gyllenberg Foundation; Academy of
   Finland (AKA) [275074, 213225, 210595, 209072] Funding Source: Academy
   of Finland (AKA)
FX The HBCS has been supported by grants from Finska Lakaresallskapet, the
   Finnish Special Governmental Subsidy for Health Sciences, Academy of
   Finland (126775, 127437, 129255, 129306, 129907, 130326, 134791, 209072,
   210595, 213225, 263924, 275074 and 315690), Samfundet Folkhalsan, Liv
   och Halsa, EU FP7 [Developmental Origins of Healthy Aging (DORIAN)]
   project number 278603, and EU H2020-PHC-2014-DynaHealth grant 633595 and
   EU Horizon 2020 Award 733206 LIFECYCLE (all for the Helsinki Birth
   Cohort Study), European Commission, Horizon2020 award 733280 RECAP),
   Foundation for Cardiovascular Research, Foundation for Diabetes
   Research, Foundation for Pediatric Research, Novo Nordisk Foundation,
   Signe and Ane Gyllenberg Foundation.
CR Abate G, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/7039816
   Atzeni IM, 2022, METHODS, V203, P533, DOI 10.1016/j.ymeth.2021.02.016
   Barker DJP, 2005, NEW ENGL J MED, V353, P1802, DOI 10.1056/NEJMoa044160
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   BECK AT, 1988, CLIN PSYCHOL REV, V8, P77, DOI 10.1016/0272-7358(88)90050-5
   BERWICK DM, 1991, MED CARE, V29, P169, DOI 10.1097/00005650-199102000-00008
   Brouwers O, 2010, DIABETOLOGIA, V53, P989, DOI 10.1007/s00125-010-1677-0
   Brouwers O, 2011, J BIOL CHEM, V286, P1374, DOI 10.1074/jbc.M110.144097
   CHARLSON ME, 1987, J CHRON DIS, V40, P373, DOI 10.1016/0021-9681(87)90171-8
   Clynes R, 2007, CURR MOL MED, V7, P743
   Cohen J., 1988, STAT POWER ANAL BEHA, DOI [10.4324/9780203771587, DOI 10.4324/9780203771587]
   Emanuele E, 2011, NEUROSCI LETT, V487, P99, DOI 10.1016/j.neulet.2010.10.003
   Emmerink D, 2018, BJPSYCH OPEN, V4, P313, DOI 10.1192/bjo.2018.34
   Eriksson JG, 2016, ANN MED, V48, P456, DOI 10.1080/07853890.2016.1193786
   Fishman SL, 2018, MOL MED, V24, DOI 10.1186/s10020-018-0060-3
   FOSSATI P, 1982, CLIN CHEM, V28, P2077
   Gaens KHJ, 2013, CURR OPIN LIPIDOL, V24, P4, DOI 10.1097/MOL.0b013e32835aea13
   Hagen JM, 2017, J CLIN PSYCHIAT, V78, P1395, DOI 10.4088/JCP.16m10972
   Isami F, 2018, J INT MED RES, V46, P1043, DOI 10.1177/0300060517736914
   Koetsier M, 2010, DIABETES TECHNOL THE, V12, P399, DOI 10.1089/dia.2009.0113
   LAKKA TA, 1992, INT J EPIDEMIOL, V21, P467, DOI 10.1093/ije/21.3.467
   Lamers F, 2013, MOL PSYCHIATR, V18, P692, DOI 10.1038/mp.2012.144
   LIE RF, 1976, CLIN CHEM, V22, P1627
   Malhi GS, 2018, LANCET, V392, P2299, DOI 10.1016/S0140-6736(18)31948-2
   Meerwaldt R, 2004, DIABETOLOGIA, V47, P1324, DOI 10.1007/s00125-004-1451-2
   Ohnuma T, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00082
   Onete V, 2018, J PSYCHIATR NEUROSCI, V43, P111, DOI 10.1503/jpn.160246
   Organization W.H., 2017, Depression and other common mental disorders: Global health estimates
   Penninx BWJH, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-129
   Roberts AL, 2018, JAMA PSYCHIAT, V75, P1225, DOI 10.1001/jamapsychiatry.2018.2462
   Rumpf HJ, 2001, PSYCHIAT RES, V105, P243, DOI 10.1016/S0165-1781(01)00329-8
   Sell DR, 2012, GERONTOLOGY, V58, P227, DOI 10.1159/000334668
   Seppälä J, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-145
   Seppälä J, 2012, J AFFECT DISORDERS, V138, P473, DOI 10.1016/j.jad.2012.01.007
   Seppälä J, 2012, J AFFECT DISORDERS, V136, P543, DOI 10.1016/j.jad.2011.10.032
   Spauwen PJJ, 2015, J CLIN ENDOCR METAB, V100, P951, DOI 10.1210/jc.2014-2754
   Tiemeier H, 2003, J AM GERIATR SOC, V51, P1105, DOI 10.1046/j.1532-5415.2003.51359.x
   Umesawa M, 2017, HYPERTENS RES, V40, P213, DOI 10.1038/hr.2016.126
   van de Lagemaat EE, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020482
   van Dooren FEP, 2017, DEPRESS ANXIETY, V34, P59, DOI 10.1002/da.22527
   van Sloten TT, 2014, PSYCHOL MED, V44, P1403, DOI 10.1017/S0033291713002043
   van Waateringe RP, 2016, EUR J CLIN INVEST, V46, P481, DOI 10.1111/eci.12627
   Vanhala M, 2009, ACTA PSYCHIAT SCAND, V119, P137, DOI 10.1111/j.1600-0447.2008.01283.x
   World Health Organization, 2020, DEPR OTH COMM MENT D
   Yamagishi S, 2011, EXP GERONTOL, V46, P217, DOI 10.1016/j.exger.2010.11.007
NR 45
TC 9
Z9 9
U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD JUN
PY 2021
VL 145
AR 110488
DI 10.1016/j.jpsychores.2021.110488
EA MAY 2021
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA SA1HZ
UT WOS:000649050200045
PM 33863506
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Soares, NP
   dos Santos, ACS
   Costa, EC
   Azevedo, GD
   Damasceno, DC
   Fayh, APT
   Lemos, TMAM
AF Soares, Nayara Pereira
   Souza dos Santos, Ana Celly
   Costa, Eduardo Caldas
   Azevedo, George Dantas
   Damasceno, Debora Cristina
   Trussardi Fayh, Ana Paula
   Araujo Moura Lemos, Telma Maria
TI Diet-Induced Weight Loss Reduces DNA Damage and Cardiometabolic Risk
   Factors in Overweight/Obese Women with Polycystic Ovary Syndrome
SO ANNALS OF NUTRITION AND METABOLISM
LA English
DT Article
DE Diet; DNA damage; Cardiometabolic risk factors; Overweight; Obesity;
   Polycystic ovary syndrome
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC SYNDROME; ANTHROPOMETRIC
   INDEXES; BRAZILIAN WOMEN; BODY-MASS; PREVALENCE; RESTRICTION; BLOOD;
   LYMPHOCYTES
AB Aims: We aimed to investigate the impact of following a diet to induce weight loss (500 kcal deficit per day) over DNA damage and cardiometabolic risk factors in women with overweight/obesity diagnosed with polycystic ovary syndrome (PCOS). Methods: A study was conducted in Natal, RN, Brazil selecting overweight/obese (body mass index >= 25 and <39 kg/m(2)) women (18-35 years). The levels of DNA damage were assessed by a single cell gel electrophoresis. Repeated 24 h dietary recall questionnaires, anthropometry, biochemical profile and sex hormones were collected at baseline and after 12 weeks of intervention. Results: Women exhibiting a decrease in the markers of DNA damage: tail intensity (24.35 +/- 5.86 - pre diet vs. 17.15 +/- 5.04 - post-diet; p < 0.001) and tail moment (20.47 +/- 7.85 - pre diet vs. 14.13 +/- 6.29 - post-diet; p < 0.002). Reduction of calorie intake, weight loss, decreased sexual hormone and cardiometabolic markers such as insulin, homeostasis model assessment of insulin resistance and low-density lipoprotein cholesterol were verified In the multivariate regression analysis, quantitative insulin sensitivity check index and progesterone were responsible for the variation markers in DNA damage before the diet, losing its influence upon diet. Conclusion: DNA damage and the impact of cardiometabolic risk factors decreased after the intervention in women with PCOS, indicating the relevance of a nutritional approach in this group of patients. (C) 2016 S. Karger AG, Basel
C1 [Soares, Nayara Pereira; Souza dos Santos, Ana Celly; Araujo Moura Lemos, Telma Maria] Univ Fed Rio Grande do Norte, Dept Clin & Toxicol, BR-59010180 Natal, RN, Brazil.
   [Costa, Eduardo Caldas] Univ Fed Rio Grande do Norte, Dept Phys Educ, BR-59010180 Natal, RN, Brazil.
   [Azevedo, George Dantas] Univ Fed Rio Grande do Norte, Dept Morphol, BR-59010180 Natal, RN, Brazil.
   [Trussardi Fayh, Ana Paula] Univ Fed Rio Grande do Norte, Dept Nutr, BR-59010180 Natal, RN, Brazil.
   [Damasceno, Debora Cristina] Sao Paulo State Univ, Dept Gynecol & Obstet, Botucatu Sch Med, Sao Paulo, Brazil.
C3 Universidade Federal do Rio Grande do Norte; Universidade Federal do Rio
   Grande do Norte; Universidade Federal do Rio Grande do Norte;
   Universidade Federal do Rio Grande do Norte; Universidade Estadual
   Paulista
RP Soares, NP (corresponding author), Univ Fed Rio Grande do Norte, Fac Farm, Dept Anal Clin & Toxicol, Rua Gen Cordeiro Petropolis, BR-59010180 Natal, RN, Brazil.
EM nayara.pereirasoares@gmail.com
RI ; Damasceno, Debora Cristina/C-7234-2012; Caldas Costa,
   Eduardo/X-7891-2018
OI LEMOS, TELMA/0000-0001-7118-2145; Damasceno, Debora
   Cristina/0000-0002-7003-9643; Caldas Costa, Eduardo/0000-0003-2807-7109
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq);
   Ministerio da Saude do Brasil; Fundacao de Apoio a Pesquisa do Estado do
   Rio Grande do Norte
FX This study was supported by the Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq), Ministerio da Saude do Brasil, and
   Fundacao de Apoio a Pesquisa do Estado do Rio Grande do Norte. The
   authors are very grateful to Rafael B. Gelaleti and Aline O. Netto for
   support in the DNA damage analysis.
CR Akamine EH, 2010, J ENDOCRINOL, V206, P65, DOI 10.1677/JOE-09-0461
   [Anonymous], 2008, GUIA AL POP BRAS PRO
   [Anonymous], 2004, METH MOL B
   [Anonymous], 2003, MUTAGENESE AMBIENTAL
   Balen A, 2001, HUM REPROD UPDATE, V7, P522, DOI 10.1093/humupd/7.6.522
   Bishop KS, 2015, NUTRIENTS, V7, P405, DOI 10.3390/nu7010405
   Calle EE, 2004, NAT REV CANCER, V4, P579, DOI 10.1038/nrc1408
   Carmina E, 2004, FERTIL STERIL, V82, P661, DOI 10.1016/j.fertnstert.2004.01.041
   Chang J, 2004, FERTIL STERIL, V81, P19, DOI 10.1016/j.fertnstert.2003.10.004
   Cohen J., 1988, STAT POWER ANAL BEHA, DOI [10.4324/9780203771587, DOI 10.4324/9780203771587]
   Collins AR, 2003, CARCINOGENESIS, V24, P511, DOI 10.1093/carcin/24.3.511
   Costa EC, 2012, GYNECOL ENDOCRINOL, V28, P12, DOI 10.3109/09513590.2011.583956
   Crosignani PG, 2003, HUM REPROD, V18, P1928, DOI 10.1093/humrep/deg367
   Dandona P, 2001, J CLIN ENDOCR METAB, V86, P355, DOI 10.1210/jc.86.1.355
   de Azevedo MF, 2011, REV BRAS GINECOL OBS, V33, P31
   Dincer Y, 2005, SCAND J CLIN LAB INV, V65, P721, DOI 10.1080/00365510500375263
   Donmez-Altuntas H, 2014, MUTAT RES-GEN TOX EN, V771, P30, DOI 10.1016/j.mrgentox.2014.06.006
   Dow CA, 2013, J AM HEART ASSOC, V2, DOI 10.1161/JAHA.113.000152
   Ehrmann DA, 2005, NEW ENGL J MED, V352, P1223, DOI 10.1056/NEJMra041536
   Ehrmann DA, 2005, J CLIN ENDOCR METAB, V90, P66, DOI 10.1210/jc.2004-0229
   Evans MD, 2004, MUTAT RES-REV MUTAT, V567, P1, DOI 10.1016/j.mrrev.2003.11.001
   Fearnley EJ, 2010, CANCER CAUSE CONTROL, V21, P2303, DOI 10.1007/s10552-010-9658-7
   Fenkci V, 2003, FERTIL STERIL, V80, P123, DOI 10.1016/S0015-0282(03)00571-5
   de Sá JCF, 2011, GYNECOL ENDOCRINOL, V27, P443, DOI 10.3109/09513590.2010.501881
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   FerroLuzzi A, 1995, WHO TECH REP SER, V854, P1
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Gaziev AI, 1996, CARCINOGENESIS, V17, P493, DOI 10.1093/carcin/17.3.493
   González F, 2006, J CLIN ENDOCR METAB, V91, P336, DOI 10.1210/jc.2005-1696
   Heilbronn LK, 2006, JAMA-J AM MED ASSOC, V295, P1539, DOI 10.1001/jama.295.13.1539
   Hofer T, 2008, REJUV RES, V11, P793, DOI 10.1089/rej.2008.0712
   Hyderali BN, 2015, EUR J OBSTET GYN R B, V191, P15, DOI 10.1016/j.ejogrb.2015.05.005
   Kryston TB, 2011, MUTAT RES-FUND MOL M, V711, P193, DOI 10.1016/j.mrfmmm.2010.12.016
   Kurdoglu Z, 2012, J ENDOCRINOL INVEST, V35, P317, DOI 10.3275/7682
   Legro RS, 2013, J CLIN ENDOCR METAB, V98, P4565, DOI 10.1210/jc.2013-2350
   Legro RS, 1999, J CLIN ENDOCR METAB, V84, P165, DOI 10.1210/jc.84.1.165
   Liu Jin, 2012, Sichuan Da Xue Xue Bao Yi Xue Ban, V43, P187
   LOFT S, 1995, CANCER EPIDEM BIOMAR, V4, P515
   Soares EMM, 2008, FERTIL STERIL, V89, P649, DOI 10.1016/j.fertnstert.2007.03.081
   Mani H, 2013, CLIN ENDOCRINOL, V78, P926, DOI 10.1111/cen.12068
   March WA, 2010, HUM REPROD, V25, P544, DOI 10.1093/humrep/dep399
   Margetts B, 2003, PUBLIC HEALTH NUTR, V6, P323, DOI 10.1079/PHN2003481
   Mohamadin Ahmed M, 2010, Pathophysiology, V17, P189, DOI 10.1016/j.pathophys.2009.11.004
   Moran L, 2006, REPROD BIOMED ONLINE, V12, P569, DOI 10.1016/S1472-6483(10)61182-0
   Moran LJ, 2008, MUTAT RES-FUND MOL M, V639, P55, DOI 10.1016/j.mrfmmm.2007.11.007
   Moran LJ, 2013, J ACAD NUTR DIET, V113, P520, DOI 10.1016/j.jand.2012.11.018
   Moran LJ, 2003, J CLIN ENDOCR METAB, V88, P812, DOI 10.1210/jc.2002-020815
   Murri M, 2013, HUM REPROD UPDATE, V19, P268, DOI 10.1093/humupd/dms059
   Navarro SD, 2015, GENET MOL RES, V14, P1679, DOI 10.4238/2015.March.6.14
   Nybacka Å, 2011, FERTIL STERIL, V96, P1508, DOI 10.1016/j.fertnstert.2011.09.006
   Pontes AG, 2012, REV BRAS GINECOL OBS, V34, P74, DOI 10.1590/S0100-72032012000200006
   Sabuncu T, 2001, CLIN BIOCHEM, V34, P407, DOI 10.1016/S0009-9120(01)00245-4
   dos Santos ACS, 2015, GYNECOL ENDOCRINOL, V31, P225, DOI 10.3109/09513590.2014.976546
   Mitjavila MT, 2013, CLIN NUTR, V32, P172, DOI 10.1016/j.clnu.2012.08.002
   Trumbo P, 2002, J AM DIET ASSOC, V102, P1621, DOI 10.1016/S0002-8223(02)90346-9
   Vrbikova J, 2009, OBESITY FACTS, V2, P26, DOI 10.1159/000194971
   Wang D, 1998, MUTAT RES-FUND MOL M, V400, P99, DOI 10.1016/S0027-5107(98)00066-9
   Wild RA, 2010, J CLIN ENDOCR METAB, V95, P2038, DOI 10.1210/jc.2009-2724
   Xavier HT, 2013, ARQ BRAS CARDIOL, V101, P1, DOI 10.5935/abc.2013S010
   Yesilada E, 2006, EUR J ENDOCRINOL, V154, P563, DOI 10.1530/eje.1.02117
NR 60
TC 22
Z9 26
U1 0
U2 10
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-6807
EI 1421-9697
J9 ANN NUTR METAB
JI Ann. Nutr. Metab.
PY 2016
VL 68
IS 3
BP 220
EP 227
DI 10.1159/000444130
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA DL7EP
UT WOS:000375803700009
PM 27073909
OA Green Published
DA 2025-06-11
ER

PT J
AU Marrone, G
   Urciuoli, S
   Di Lauro, M
   Cornali, K
   Montalto, G
   Masci, C
   Vanni, G
   Tesauro, M
   Vignolini, P
   Noce, A
AF Marrone, Giulia
   Urciuoli, Silvia
   Di Lauro, Manuela
   Cornali, Kevin
   Montalto, Giulia
   Masci, Claudia
   Vanni, Gianluca
   Tesauro, Manfredi
   Vignolini, Pamela
   Noce, Annalisa
TI Saffron (Crocus sativus L.) and Its By-Products: Healthy Effects
   in Internal Medicine
SO NUTRIENTS
LA English
DT Review
DE circular economy; Crocus sativus L.; by-products; natural bioactive
   compounds; metabolic syndrome; chronic kidney diseases; depression
ID METABOLIC SYNDROME; OXIDATIVE STRESS; EXTRACT; IDENTIFICATION; CROCETIN;
   STIGMAS; GLUCOSE; SUPPLEMENTATION; INFLAMMATION; SENSITIVITY
AB Crocus sativus L., commonly known as saffron, is a precious spice coming from Asia, in particular from Iran, the country leader in its production. The spice is derived exclusively from dried stigmas and it is the most expensive one in the world. The areas of application of saffron are multiple, in fact ranging across the food, drinks, pharmaceuticals and cosmetics sectors. As is the case with other phytochemicals, not only the final product but also saffron by-products are considered a valuable source of bioactive natural compounds. In fact, its healthy effects, especially as antioxidants and anti-inflammatories (via reducing pro-inflammatory cytokines), are well-recognized in internal medicine. In particular, its healthy effects are related to counteracting degenerative maculopathy, depression and anxiety, neurodegenerative diseases, metabolic syndrome, cancer and chronic kidney disease, by promoting glucose metabolism. In this review, we summarize the most important papers in which saffron has turned out to be a valuable ally in the prevention and treatment of these pathologies. Moreover, we would like to promote the use of saffron by-products as part of a bio-circular economy system, aimed at reducing wastes, at maximizing the use of resources and at promoting environmental and economic sustainability.
C1 [Marrone, Giulia; Di Lauro, Manuela; Cornali, Kevin; Masci, Claudia; Tesauro, Manfredi; Noce, Annalisa] Univ Roma Tor Vergata, Dept Syst Med, Gastroenterol Unit, I-00133 Rome, Italy.
   [Urciuoli, Silvia; Vignolini, Pamela] Univ Florence, Dept Stat Comp Sci Applicat Giuseppe Parenti DiSIA, PHYTOLAB Lab Pharmaceut Cosmet Food Supplement Tec, Via Ugo Schiff 6, I-50019 Florence, Italy.
   [Montalto, Giulia] Univ Roma Tor Vergata, Sch Specializat Nephrol, I-00133 Rome, Italy.
   [Vanni, Gianluca] Tor Vergata Univ, Dept Surg Sci, Breast Unit Policlin Tor Vergata, Viale Oxford 81, I-00133 Rome, Italy.
   [Noce, Annalisa] Policlin Tor Vergata, Nephrol & Dialysis Unit, I-00133 Rome, Italy.
C3 University of Rome Tor Vergata; University of Florence; University of
   Rome Tor Vergata; University of Rome Tor Vergata; University of Rome Tor
   Vergata; Policlin Tor Vergata
RP Cornali, K; Noce, A (corresponding author), Univ Roma Tor Vergata, Dept Syst Med, Gastroenterol Unit, I-00133 Rome, Italy.; Noce, A (corresponding author), Policlin Tor Vergata, Nephrol & Dialysis Unit, I-00133 Rome, Italy.
EM giulia.marrone@uniroma2.it; silvia.urciuoli@unifi.it;
   dilauromanuela@gmail.com; cornali.kevin@hotmail.it;
   giulia.montalto@ptvonline.it; masciclaudia@gmail.com;
   vanni_gianluca@yahoo.it; mtesauro@tiscali.it; pamela.vignolini@unifi.it;
   annalisa.noce@uniroma2.it
RI Marrone, Giulia/IQR-7760-2023; Di Lauro, Manuela/AAB-9784-2022; Noce,
   Annalisa/B-5558-2019; Vanni, Gianluca/AAJ-9743-2020
OI Di Lauro, Manuela/0000-0001-8118-1330; NOCE,
   ANNALISA/0000-0003-1310-3730; VIGNOLINI, PAMELA/0000-0002-9500-7971;
   Marrone, Giulia/0000-0002-5854-2086; vanni,
   gianluca/0000-0002-3006-5855; URCIUOLI, SILVIA/0000-0001-8139-3229;
   Cornali, Kevin/0009-0004-8904-4399; , Giulia
   Montalto/0009-0004-3501-6894
FX We would like to thank Rome Technopole spoke V for the scientific
   support and the Cassa di Risparmio Firenze Foundation-Call for
   Researchers in Florence 2023 edition-Molecules Project.
CR Abu-Izneid T, 2022, CRIT REV FOOD SCI, V62, P2683, DOI 10.1080/10408398.2020.1857682
   Ahmadnia H, 2021, UROL J, V18, P633, DOI [10.22037/uj.v16i7.6331], 10.22037/uj.v16i7.6331]
   Akchurin OM, 2015, BLOOD PURIFICAT, V39, P84, DOI 10.1159/000368940
   Alexandri M, 2023, TRENDS FOOD SCI TECH, V139, DOI 10.1016/j.tifs.2023.104123
   [Anonymous], 2011, SpicesSaffron (Crocus sativus L.)Part 1: Specification
   [Anonymous], about us
   Arasteh A, 2010, J MED PLANTS RES, V4, P397
   Asadi F, 2015, PHARMACOL BIOCHEM BE, V139, P47, DOI 10.1016/j.pbb.2015.10.011
   Asbaghi O, 2021, PHYTOTHER RES, V35, P20, DOI 10.1002/ptr.6748
   Ayati Z, 2020, BMC COMPLEMENT MED, V20, DOI 10.1186/s12906-020-03102-3
   Baba SA, 2015, S AFR J BOT, V99, P80, DOI 10.1016/j.sajb.2015.03.194
   Bakshi RA, 2022, APPL FOOD RES, V2, DOI 10.1016/j.afres.2022.100076
   Bamalan O A., 2024, StatPearls
   Bastani S, 2022, BIOMED PHARMACOTHER, V153, DOI 10.1016/j.biopha.2022.113297
   Beal MF, 2002, FREE RADICAL BIO MED, V32, P797, DOI 10.1016/S0891-5849(02)00780-3
   Bian YQ, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.579052
   Bolhassani A, 2014, BBA-REV CANCER, V1845, P20, DOI 10.1016/j.bbcan.2013.11.001
   Brownlee M, 2003, J CLIN INVEST, V112, P1788, DOI 10.1172/JCI200320501
   BUETTNER GR, 1993, ARCH BIOCHEM BIOPHYS, V300, P535, DOI 10.1006/abbi.1993.1074
   Cardone L, 2020, SCI HORTIC-AMSTERDAM, V272, DOI 10.1016/j.scienta.2020.109560
   Carmona M, 2006, J AGR FOOD CHEM, V54, P973, DOI 10.1021/jf052297w
   Carmona M, 2007, FOOD CHEM, V100, P445, DOI 10.1016/j.foodchem.2005.09.065
   Cerdá-Bernad D, 2022, NUTRIENTS, V14, DOI 10.3390/nu14245368
   Chen SS, 2015, TRANSL LUNG CANCER R, V4, P775, DOI 10.3978/j.issn.2218-6751.2015.11.03
   Chew EY, 2012, OPHTHALMOLOGY, V119, P2282, DOI 10.1016/j.ophtha.2012.05.027
   D'Alessandro AM, 2013, NUTR CANCER, V65, P930, DOI 10.1080/01635581.2013.767368
   Dessì M, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-54
   Dong N, 2020, PARKINSONS DIS-US, V2020, DOI 10.1155/2020/9864370
   Ebrahimi F, 2019, AVICENNA J PHYTOMEDI, V9, P322, DOI 10.22038/AJP.2019.12785
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Falsini B, 2010, INVEST OPHTH VIS SCI, V51, P6118, DOI 10.1167/iovs.09-4995
   Fernandez J.A., 2004, Biology, Biotechnology and Biomedicine of Saffron, VVolume 2, P127
   Forouzanfar F, 2021, N-S ARCH PHARMACOL, V394, P707, DOI 10.1007/s00210-020-01999-8
   Gahruie HH, 2020, J APPL RES MED AROMA, V19, DOI 10.1016/j.jarmap.2020.100264
   García-Rodríguez MV, 2017, FOOD CHEM, V221, P838, DOI 10.1016/j.foodchem.2016.11.089
   Gezici S, 2019, J FOOD SCI TECH MYS, V56, P5435, DOI 10.1007/s13197-019-04014-y
   Gigliobianco MR, 2021, COSMETICS-BASEL, V8, DOI 10.3390/cosmetics8020051
   Gohari Ahmad Reza, 2013, Pharmacogn Rev, V7, P61, DOI 10.4103/0973-7847.112850
   Golpour-Hamedani S, 2024, HELIYON, V10, DOI 10.1016/j.heliyon.2024.e24334
   Goupy P, 2013, IND CROP PROD, V44, P496, DOI 10.1016/j.indcrop.2012.10.004
   Gracia L, 2009, BIOSYST ENG, V104, P8, DOI 10.1016/j.biosystemseng.2009.06.003
   Guerrero-Romero F, 2005, DIABETES CARE, V28, P2588
   Hosseinzadeh H, 2007, PHARM ONLINE, V2, P367
   Javandoost A, 2017, ARYA ATHEROSCLER, V13, P245
   Kabiri M, 2017, LWT-FOOD SCI TECHNOL, V84, P1, DOI 10.1016/j.lwt.2017.05.033
   Kalantar-Zadeh K, 2021, LANCET, V398, P786, DOI 10.1016/S0140-6736(21)00519-5
   Kang C, 2012, FOOD CHEM, V135, P2350, DOI 10.1016/j.foodchem.2012.06.092
   Karimi E, 2010, MOLECULES, V15, P6244, DOI 10.3390/molecules15096244
   Karimi E, 2022, INT J CLIN PRACT, V2022, DOI 10.1155/2022/9622546
   Kazemi T, 2023, CLIN NUTR ESPEN, V55, P314, DOI 10.1016/j.clnesp.2023.04.002
   Kermani T, 2015, AVICENNA J PHYTOMEDI, V5, P427
   Khadfy Z, 2023, S AFR J BOT, V163, P250, DOI 10.1016/j.sajb.2023.10.058
   Kooman JP, 2017, AM J PHYSIOL-RENAL, V313, pF938, DOI 10.1152/ajprenal.00256.2017
   Kumar A., 2024, StatPearls
   Kumar A, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-15907-y
   Lahmass I, 2017, J FUNCT FOODS, V35, P341, DOI 10.1016/j.jff.2017.05.057
   Lakka A, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8120586
   Lopresti AL, 2014, HUM PSYCHOPHARM CLIN, V29, P517, DOI 10.1002/hup.2434
   Lozon L, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.938471
   Lu CC, 2021, PHYTOMEDICINE, V91, DOI 10.1016/j.phymed.2021.153699
   Lucas C D, 2001, Adv Food Nutr Res, V43, P195, DOI 10.1016/S1043-4526(01)43005-1
   Luo YS, 2021, ONCOTARGETS THER, V14, P111, DOI 10.2147/OTT.S254167
   Marrone G, 2024, LIFE-BASEL, V14, DOI 10.3390/life14010049
   Marx W, 2019, NUTR REV, V77, P557, DOI 10.1093/nutrit/nuz023
   Matraszek-Gawron R, 2023, PHARMACEUTICALS-BASE, V16, DOI 10.3390/ph16010058
   Mazidi Mohsen, 2016, J Complement Integr Med, V13, P195, DOI 10.1515/jcim-2015-0043
   Melnyk J. P., 2010, Food Research International, V43, P1981, DOI 10.1016/j.foodres.2010.07.033
   Menghini L, 2018, FOOD RES INT, V109, P91, DOI 10.1016/j.foodres.2018.04.028
   Modaghegh MH, 2008, PHYTOMEDICINE, V15, P1032, DOI 10.1016/j.phymed.2008.06.003
   Mohajeri D., 2009, Journal of Biological Sciences, V9, P302, DOI 10.3923/jbs.2009.302.310
   Mohammadi Y, 2023, FOOD SCI NUTR, V11, P2429, DOI 10.1002/fsn3.3302
   Mojtahedi S, 2022, EXP GERONTOL, V162, DOI 10.1016/j.exger.2022.111756
   Montoro P, 2012, J FOOD SCI, V77, pC893, DOI 10.1111/j.1750-3841.2012.02803.x
   Moshfegh F, 2022, J ETHNOPHARMACOL, V282, DOI 10.1016/j.jep.2021.114594
   Mykhailenko O, 2022, MOLECULES, V27, DOI 10.3390/molecules27010010
   Mykhailenko O, 2021, SCI PHARM, V89, DOI 10.3390/scipharm89020028
   Mykhailenko O, 2020, IND CROP PROD, V151, DOI 10.1016/j.indcrop.2020.112376
   Noce A, 2022, EUR REV MED PHARMACO, V26, P2057, DOI 10.26355/eurrev_202203_28354
   Noce A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020630
   Ohno Y, 2012, EUR J PHARMACOL, V690, P84, DOI 10.1016/j.ejphar.2012.06.035
   Pan PK, 2016, CELL MOL BIOL, V62, P11, DOI [10.14715/cmb/2016.62.14.2, 10.14715/cmb/ 2016.62.14.2]
   Pandita D., 2021, Med. Aromat. Plants, P325, DOI [10.1016/b978-0-12-819590-1.00014-8, DOI 10.1016/B978-0-12-819590-1.00014-8, 10.1016/B978-0-12-819590-1.00014-8]
   Papandreou MA, 2006, J AGR FOOD CHEM, V54, P8762, DOI 10.1021/jf061932a
   Patel KS, 2024, J ETHNOPHARMACOL, V326, DOI 10.1016/j.jep.2024.117898
   Peng A, 2005, ANN ACAD MED SINGAP, V34, P44
   Piccardi M, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/429124
   Pitsikas N, 2016, MOLECULES, V21, DOI 10.3390/molecules21030303
   RICKER K, 1990, ARCH NEUROL-CHICAGO, V47, P810, DOI 10.1001/archneur.1990.00530070108019
   Ronsisvalle S, 2023, PLANTS-BASEL, V12, DOI 10.3390/plants12203606
   Roshanravan B, 2022, ARCH PHYSIOL BIOCHEM, V128, P666, DOI 10.1080/13813455.2020.1716020
   Ruggieri F, 2023, MOLECULES, V28, DOI 10.3390/molecules28165976
   Samarghandian S., 2016, Der Pharm Lett, V8, P283
   Samarghandian S, 2010, PHARMACOGN MAG, V6, P309, DOI 10.4103/0973-1296.71799
   Schmidt M, 2007, WIEN MED WOCHENSCHR, V157, P315, DOI 10.1007/s10354-007-0428-4
   Serrano-Díaz J, 2014, J AGR FOOD CHEM, V62, P3125, DOI 10.1021/jf4057023
   Serrano-Díaz J, 2012, J FOOD SCI, V77, pC1162, DOI 10.1111/j.1750-3841.2012.02926.x
   Shariatifar N, 2014, J ADV PHARM TECHNOL, V5, P17, DOI 10.4103/2231-4040.126982
   Sharma N, 2023, 3 BIOTECH, V13, DOI 10.1007/s13205-023-03669-x
   Shen JK, 2007, HISTOL HISTOPATHOL, V22, P1301, DOI 10.14670/HH-22.1301
   Smolskaite L., Innovations for Food Science and Production, Proceedings of the 6th Baltic Conference on Food Science and Technology FOODBALT-2011, Jelgava, Latvia, 56 May 2011, P67
   Cid-Pérez TS, 2021, MOLECULES, V26, DOI 10.3390/molecules26226954
   Srivastava R, 2010, Pharmacogn Rev, V4, P200, DOI 10.4103/0973-7847.70919
   Stelluti S, 2021, PLANTS-BASEL, V10, DOI 10.3390/plants10030523
   Sut S, 2024, J FOOD BIOCHEM, V2024, DOI 10.1155/2024/6672608
   Tajik S, 2019, SCI HORTIC-AMSTERDAM, V257, DOI 10.1016/j.scienta.2019.108751
   Tóth B, 2019, PLANTA MED, V85, P24, DOI 10.1055/a-0660-9565
   Tu J, 2023, INT J BIOL MACROMOL, V248, DOI 10.1016/j.ijbiomac.2023.125878
   Vago R, 2024, FOOD BIOSCI, V57, DOI 10.1016/j.fbio.2023.103501
   Verma S, 2021, KIDNEY RES CLIN PRAC, V40, P183, DOI 10.23876/j.krcp.20.163
   Vignolini P, 2008, NAT PROD COMMUN, V3, P1959
   Xi L, 2007, J NUTR BIOCHEM, V18, P64, DOI 10.1016/j.jnutbio.2006.03.010
   Yadav S, 2024, MOLECULES, V29, DOI 10.3390/molecules29092055
   Zandi N, 2021, ARCH IRAN MED, V24, P233, DOI 10.34172/aim.2021.35
   Zarei B, 2022, IRAN J BASIC MED SCI, V25, P419, DOI [10.22038/IJBMS.2022.61344.13570, 10.22038/ijbms.2022.61344.13570]
   Zheng J, 2016, NUTRIENTS, V8, DOI 10.3390/nu8080495
NR 115
TC 8
Z9 8
U1 1
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2024
VL 16
IS 14
AR 2319
DI 10.3390/nu16142319
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ZX7I6
UT WOS:001278646300001
PM 39064764
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Milaneschi, Y
   Lamers, F
   Berk, M
   Penninx, BWJH
AF Milaneschi, Yuri
   Lamers, Femke
   Berk, Michael
   Penninx, Brenda W. J. H.
TI Depression Heterogeneity and Its Biological Underpinnings: Toward
   Immunometabolic Depression
SO BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Depression; Heterogeneity; Homeostasis; Inflammation; Metabolism;
   Treatment
ID C-REACTIVE PROTEIN; BODY-MASS INDEX; MAJOR DEPRESSION; ATYPICAL
   DEPRESSION; METABOLIC SYNDROME; ABDOMINAL OBESITY; METAANALYSIS;
   ASSOCIATION; LEPTIN; ANXIETY
AB Epidemiological evidence indicates the presence of dysregulated homeostatic biological pathways in depressed patients, such as increased inflammation and disrupted energy-regulating neuroendocrine signaling (e.g., leptin, insulin). Alterations in these biological pathways may explain the considerable comorbidity between depression and cardiometabolic conditions (e.g., obesity, metabolic syndrome, diabetes) and represent a promising target for intervention. This review describes how immunometabolic dysregulations vary as a function of depression hetero-geneity by illustrating that such biological dysregulations map more consistently to atypical behavioral symptoms reflecting altered energy intake/expenditure balance (hyperphagia, weight gain, hypersomnia, fatigue, and leaden paralysis) and may moderate the antidepressant effects of standard or novel (e.g., anti-inflammatory) therapeutic approaches. These lines of evidence are integrated in a conceptual model of immunometabolic depression emerging from the clustering of immunometabolic biological dysregulations and specific behavioral symptoms. The review finally elicits questions to be answered by future research and describes how the immunometabolic depression dimension could be used to dissect the heterogeneity of depression and potentially to match subgroups of patients to specific treatments with higher likelihood of clinical success.
C1 [Milaneschi, Yuri; Lamers, Femke; Penninx, Brenda W. J. H.] Vrije Univ, Amsterdam Univ, Med Ctr, Amsterdam Publ Hlth,Dept Psychiat, Amsterdam, Netherlands.
   [Milaneschi, Yuri; Lamers, Femke; Penninx, Brenda W. J. H.] Vrije Univ, Amsterdam Univ, Med Ctr, Amsterdam Neurosci, Amsterdam, Netherlands.
   [Milaneschi, Yuri; Lamers, Femke; Penninx, Brenda W. J. H.] GGZinGeest, Amsterdam, Netherlands.
   [Berk, Michael] Deakin Univ, Sch Med, Inst Mental & Phys Hlth & Clin Treatment, Geelong, Vic, Australia.
   [Berk, Michael] Barwon Hlth, Geelong, Vic, Australia.
   [Berk, Michael] Univ Melbourne, Dept Psychiat, Natl Ctr Excellence Youth Mental Hlth, Orygen, Melbourne, Vic, Australia.
   [Berk, Michael] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia.
C3 Vrije Universiteit Amsterdam; University of Amsterdam; Vrije
   Universiteit Amsterdam; University of Amsterdam; Deakin University;
   Barwon Health; University of Melbourne; Orygen, The National Centre of
   Excellence in Youth Mental Health; Florey Institute of Neuroscience &
   Mental Health; University of Melbourne
RP Milaneschi, Y (corresponding author), Vrije Univ, GGZ inGeest, Amsterdam UMC, Dept Psychiat, Oldenaller 1, NL-1081 HJ Amsterdam, Netherlands.
EM y.milaneschi@ggzingeest.nl
RI Berk, Michael/AGH-9427-2022; Lamers, Femke/G-5161-2012; Berk,
   Michael/M-7891-2013; Penninx, Brenda WJH/S-7627-2017
OI Berk, Michael/0000-0002-5554-6946; Penninx, Brenda
   WJH/0000-0001-7779-9672; Milaneschi, Yuri/0000-0002-3697-6617
FU National Health and Medical Research Council Senior Principal Research
   Fellowship [APP1059660, APP1156072]; European Union Seventh Framework
   Programme FP7-Marie Curie Career Integration Grant
   [PCIG12-GA-2012-334065]
FX This work was supported by the National Health and Medical Research
   Council Senior Principal Research Fellowship (Grant Nos. APP1059660 and
   APP1156072 [to MB]) and European Union Seventh Framework Programme
   FP7-Marie Curie Career Integration Grant (Grant No.
   PCIG12-GA-2012-334065 [to FL]).
CR [Anonymous], 2015, NEUROSCI BIOBEHAV R, DOI DOI 10.1016/J.NEUBIOREV.2014.12.017
   [Anonymous], 2018, FRONT ENDOCRINOL, DOI DOI 10.3389/FENDO.2018.00761
   Apovian CM, 2016, FUTUR CARDIOL, V12, P129, DOI 10.2217/fca.15.79
   Arnow BA, 2015, AM J PSYCHIAT, V172, P743, DOI 10.1176/appi.ajp.2015.14020181
   Berk M, 2004, ACTA PSYCHIAT SCAND, V110, P39, DOI 10.1111/j.1600-0447.2004.00412.x
   Berk M, 2019, JAMA Psychiatry
   Berk M, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-200
   Berridge KC, 2013, CURR OPIN NEUROBIOL, V23, P294, DOI 10.1016/j.conb.2013.01.017
   Berridge KC, 2010, BRAIN RES, V1350, P43, DOI 10.1016/j.brainres.2010.04.003
   Blanco C, 2012, J CLIN PSYCHIAT, V73, P224, DOI 10.4088/JCP.10m06227
   Border R, 2019, AM J PSYCHIAT, V176, P376, DOI 10.1176/appi.ajp.2018.18070881
   Bot M, 2017, PSYCHOL MED, V47, P279, DOI 10.1017/S0033291716002312
   Bot M, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.88
   Bot M, 2020, BIOL PSYCHIAT, V87, P409, DOI 10.1016/j.biopsych.2019.08.016
   Brailean A, 2020, PSYCHOL MED, V50, P1129, DOI 10.1017/S0033291719001004
   Cannon TD, 2006, ANNU REV CLIN PSYCHO, V2, P267, DOI 10.1146/annurev.clinpsy.2.022305.095232
   Cao B, 2018, J AFFECT DISORDERS, V238, P101, DOI 10.1016/j.jad.2018.05.008
   Capuron L, 2017, NEUROPSYCHOPHARMACOL, V42, P115, DOI 10.1038/npp.2016.123
   Capuron L, 2011, PHARMACOL THERAPEUT, V130, P226, DOI 10.1016/j.pharmthera.2011.01.014
   Carvalho AF, 2014, J PSYCHIATR RES, V59, P28, DOI 10.1016/j.jpsychires.2014.08.002
   Cattaneo A, 2013, NEUROPSYCHOPHARMACOL, V38, P377, DOI 10.1038/npp.2012.191
   Chekroud AM, 2017, JAMA PSYCHIAT, V74, P370, DOI 10.1001/jamapsychiatry.2017.0025
   Chen CY, 2018, TRANSL PSYCHIAT, V8, DOI 10.1038/s41398-018-0133-7
   Cizza G, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0028912
   Cui HX, 2017, NAT REV ENDOCRINOL, V13, P338, DOI 10.1038/nrendo.2016.222
   Cuijpers P, 2017, DEPRESS ANXIETY, V34, P246, DOI 10.1002/da.22580
   Cuthbert BN, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-126
   Danese A, 2017, NEUROPSYCHOPHARMACOL, V42, P99, DOI 10.1038/npp.2016.198
   Davey Smith G, 2014, HUM MOL GENET, V23, pR89, DOI 10.1093/hmg/ddu328
   Davidson JRT, 2007, J CLIN PSYCHIAT, V68, P10
   de Wit L, 2010, PSYCHIAT RES, V178, P230, DOI 10.1016/j.psychres.2009.04.015
   de Wit LM, 2010, DEPRESS ANXIETY, V27, P1057, DOI 10.1002/da.20738
   Dortland AKBV, 2010, ACTA PSYCHIAT SCAND, V122, P30, DOI 10.1111/j.1600-0447.2010.01565.x
   Dortland AKBV, 2010, J CLIN PSYCHIAT, V71, P729, DOI 10.4088/JCP.08m04865blu
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Enache D, 2019, BRAIN BEHAV IMMUN, V81, P24, DOI 10.1016/j.bbi.2019.06.015
   Esteve E, 2005, CLIN NUTR, V24, P16, DOI 10.1016/j.clnu.2004.08.004
   Farooqi IS, 2007, NEW ENGL J MED, V356, P237, DOI 10.1056/NEJMoa063988
   Farooqi IS, 2003, NEW ENGL J MED, V348, P1085, DOI 10.1056/NEJMoa022050
   Fawcett J, 2016, AM J PSYCHIAT, V173, P107, DOI 10.1176/appi.ajp.2015.15060788
   Felger JC, 2016, MOL PSYCHIATR, V21, P1358, DOI 10.1038/mp.2015.168
   Felger JC, 2017, NEUROPSYCHOPHARMACOL, V42, P216, DOI 10.1038/npp.2016.143
   Fernandes BS, 2017, BMC MED, V15, DOI 10.1186/s12916-017-0849-x
   Fritschi C, 2010, J PSYCHOSOM RES, V69, P33, DOI 10.1016/j.jpsychores.2010.01.021
   Furman JL, 2018, PERS MED PSYCHIAT, V9-10, P1
   Glaus J, 2013, ACTA PSYCHIAT SCAND, V128, P282, DOI 10.1111/acps.12057
   Glaus J, 2014, J PSYCHIATR RES, V58, P36, DOI 10.1016/j.jpsychires.2014.07.012
   Hickman RJ, 2014, J BEHAV MED, V37, P621, DOI 10.1007/s10865-013-9510-0
   Higgins JPT, 2003, BMJ-BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557
   Hiles SA, 2017, PSYCHOL MED, V47, P1466, DOI 10.1017/S0033291716003548
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Jha MK, 2019, J PSYCHIATR RES, V113, P165, DOI 10.1016/j.jpsychires.2019.03.013
   Jha MK, 2018, J AFFECT DISORDERS, V234, P34, DOI 10.1016/j.jad.2018.02.089
   Jha MK, 2017, PSYCHONEUROENDOCRINO, V78, P105, DOI 10.1016/j.psyneuen.2017.01.023
   Jokela M, 2016, JAMA PSYCHIAT, V73, P87, DOI 10.1001/jamapsychiatry.2015.1977
   Jung SJ, 2017, BRIT J PSYCHIAT, V211, P14, DOI 10.1192/bjp.bp.116.186726
   Kan C, 2013, DIABETES CARE, V36, P480, DOI 10.2337/dc12-1442
   Kappelmann N, 2018, MOL PSYCHIATR, V23, P335, DOI 10.1038/mp.2016.167
   Khandaker GM, 2020, MOL PSYCHIATR, V25, P1477, DOI 10.1038/s41380-019-0395-3
   Köhler CA, 2017, ACTA PSYCHIAT SCAND, V135, P373, DOI 10.1111/acps.12698
   Köhler O, 2014, JAMA PSYCHIAT, V71, P1381, DOI 10.1001/jamapsychiatry.2014.1611
   Köhler-Forsherg O, 2019, ACTA PSYCHIAT SCAND, V139, P404, DOI 10.1111/acps.13016
   Lacourt TE, 2018, FRONT BEHAV NEUROSCI, V12, P1
   Lamers F, 2018, PSYCHOL MED, V48, P1102, DOI 10.1017/S0033291717002483
   Lamers F, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.115
   Lamers F, 2013, MOL PSYCHIATR, V18, P692, DOI 10.1038/mp.2012.144
   Lamers F, 2010, J CLIN PSYCHIAT, V71, P1582, DOI 10.4088/JCP.09m05398blu
   Lasserre AM, 2017, MOL PSYCHIATR, V22, P1026, DOI 10.1038/mp.2016.178
   Lasserre AM, 2014, JAMA PSYCHIAT, V71, P880, DOI 10.1001/jamapsychiatry.2014.411
   Levitan RD, 2012, J CLIN PSYCHIAT, V73, P1119, DOI 10.4088/JCP.11m07394
   Macdonald G, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001930.pub3
   McIntyre RS, 2019, JAMA PSYCHIAT, V76, P783, DOI 10.1001/jamapsychiatry.2019.0779
   Milaneschi Y, 2016, MOL PSYCHIATR, V21, P516, DOI 10.1038/mp.2015.86
   Milaneschi Y, 2014, MOL PSYCHIATR, V19, P960, DOI 10.1038/mp.2014.4
   Milaneschi Y, 2019, MOL PSYCHIATR, V24, P18, DOI 10.1038/s41380-018-0017-5
   Milaneschi Y, 2017, JAMA PSYCHIAT, V74, P1214, DOI 10.1001/jamapsychiatry.2017.3016
   Milaneschi Y, 2017, BIOL PSYCHIAT, V81, P807, DOI 10.1016/j.biopsych.2015.10.023
   Milaneschi Y, 2014, PSYCHONEUROENDOCRINO, V42, P1, DOI 10.1016/j.psyneuen.2013.12.015
   Milaneschi Y, 2012, J CLIN PSYCHIAT, V73, P1205, DOI 10.4088/JCP.11m07552
   Miller AH, 2017, NEUROPSYCHOPHARMACOL, V42, P334, DOI 10.1038/npp.2016.167
   Miller AH, 2016, NAT REV IMMUNOL, V16, P22, DOI 10.1038/nri.2015.5
   Morris G, 2015, BMC MED, V13, DOI 10.1186/s12916-015-0310-y
   Obici S, 2002, NAT MED, V8, P1376, DOI 10.1038/nm798
   Otte C, 2016, NAT REV DIS PRIMERS, V2, DOI 10.1038/nrdp.2016.65
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Parker GB, 2007, J CLIN PSYCHIAT, V68, P18
   Pasco JA, 2008, J AFFECT DISORDERS, V107, P221, DOI 10.1016/j.jad.2007.07.024
   Penninx BWJH, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-129
   Persons JE, 2016, J AFFECT DISORDERS, V206, P55, DOI 10.1016/j.jad.2016.07.033
   Quek YH, 2017, OBES REV, V18, P742, DOI 10.1111/obr.12535
   Raison CL, 2013, JAMA PSYCHIAT, V70, P31, DOI 10.1001/2013.jamapsychiatry.4
   Rethorst CD, 2013, MOL PSYCHIATR, V18, P1119, DOI 10.1038/mp.2012.125
   Rethorst CD, 2016, J AFFECT DISORDERS, V200, P156, DOI 10.1016/j.jad.2016.01.052
   Ring LE, 2010, J CLIN INVEST, V120, P2931, DOI 10.1172/JCI41985
   Sanna S, 2019, NAT GENET, V51, P600, DOI 10.1038/s41588-019-0350-x
   Serretti A, 2010, J CLIN PSYCHIAT, V71, P1259, DOI 10.4088/JCP.09r05346blu
   Shin JY, 2008, ANN BEHAV MED, V36, P33, DOI 10.1007/s12160-008-9045-8
   Simmons WK, 2020, MOL PSYCHIATR, V25, P1457, DOI 10.1038/s41380-018-0093-6
   Smith KJ, 2018, EXP GERONTOL, V102, P109, DOI 10.1016/j.exger.2017.12.005
   STEWART JW, 1993, PSYCHIAT CLIN N AM, V16, P479
   Sullivan PF, 2002, J AFFECT DISORDERS, V68, P273, DOI 10.1016/S0165-0327(00)00364-5
   Thase ME, 2007, J CLIN PSYCHIAT, V68, P11
   Thase ME, 2009, NEUROPSYCHOPHARMACOL, V34, P2633, DOI 10.1038/npp.2009.100
   Treadway MT, 2019, TRENDS COGN SCI, V23, P435, DOI 10.1016/j.tics.2019.03.003
   Uher R, 2014, AM J PSYCHIAT, V171, P1278, DOI 10.1176/appi.ajp.2014.14010094
   Uher R, 2011, J AFFECT DISORDERS, V132, P112, DOI 10.1016/j.jad.2011.02.014
   Uher R, 2009, J AFFECT DISORDERS, V118, P147, DOI 10.1016/j.jad.2009.02.013
   van der Klaauw AA, 2015, CELL, V161, P119, DOI 10.1016/j.cell.2015.03.008
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vogelzangs N, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.8
   Williams LM, 2016, LANCET PSYCHIAT, V3, P472, DOI 10.1016/S2215-0366(15)00579-9
   Xu QY, 2011, OBES RES CLIN PRACT, V5, pE267, DOI 10.1016/j.orcp.2011.04.007
   Yohn SE, 2016, PSYCHOPHARMACOLOGY, V233, P3575, DOI 10.1007/s00213-016-4392-9
NR 113
TC 241
Z9 250
U1 13
U2 157
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD SEP 1
PY 2020
VL 88
IS 5
BP 369
EP 380
DI 10.1016/j.biopsych.2020.01.014
PG 12
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA ND0MO
UT WOS:000561602700006
PM 32247527
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Demir, B
   Temizhan, A
   Keskin, G
   Baser, K
   Turak, O
   Cay, S
AF Demir, Bulent
   Temizhan, Ahmet
   Keskin, Gokhan
   Baser, Kazim
   Turak, Osman
   Cay, Serkan
TI Comparison of serum gamma-glutamyltransferase levels between patients
   with cardiac syndrome X and healthy asymptomatic individuals
SO KARDIOLOGIA POLSKA
LA English
DT Article
DE cardiac syndrome X; gamma-glutamyltransferase; oxidative stress
ID STABLE ANGINA-PECTORIS; SLOW CORONARY FLOW; METABOLIC SYNDROME;
   OXIDATIVE STRESS; DISEASE; ATHEROSCLEROSIS; RISK
AB Background: Gamma-glutamyltransferase (GGT) enzyme has an increasing importance in the pathophysiology and prognosis of cardiovascular diseases. It is an indirect marker of microvascular endothelial dysfunction, atherosclerosis, and elevated oxidative stress. There are no adequate data on the relationship between GGT and cardiac syndrome X. Aim: To compare serum GGT levels between patients with cardiac syndrome X and asymptomatic healthy individuals.
   Methods: Fifty consecutive patients (29 female, 21 male, aged 28-81 years) who underwent coronary angiography due to objective ischaemia and were eventually diagnosed with cardiac syndrome X between July 2009 and January 2010, and 50 healthy asymptomatic control individuals (28 female, 22 male, aged 30-78 years) were studied. Venous blood samples were collected for GOT measurements. A metabolic syndrome (MS) subgroup composed of 15 individuals was formed within the cardiac syndrome X group.
   Results: Serum total cholesterol, LDL-cholesterol, and triglyceride (TG) levels were significantly higher in the cardiac syndrome X patients than in the control group (195.28 +/- 33.71 mg/dL and 168.82 +/- 31.45 mg/dL, p < 0.01, 121.62 +/- 30.53 mg/dL and 98.44 +/- 27.28 mg/dL, p < 0.01, 144.30 +/- 68.54 mg/dL and 108.94 +/- 43.59 mg/dL, p < 0.01, respectively). Serum GGT levels were also significantly higher in the cardiac syndrome X patients than in the control group (30.48 +/- 16.36 and 17.88 +/- 6. 89 U/L, p < 0.001). The MS patients (n = 15) had significantly higher TG and GGT levels (230.00 +/- 41.37 mg/dL and 107.57 +/- 37.90 mg/dL, p < 0.01, 38.47 +/- 21.27 U/L and 27.06 +/- 12.61 U/L, p < 0.001, respectively) and lower HDL levels (35.47 +/- 6.91 mg/dL and 48.26 +/- 9.97 mg/dL, p < 0.05) compared to patients without MS. The cardiac syndrome X group exhibited a significant positive correlation between GGT and body mass index, and GGT and TG (r = 0.321, p = 0.023, r = 0.293, p = 0.039, respectively).
   Conclusions: GGT activity in patients with cardiac syndrome X was higher than in healthy controls. Moreover, GGT activity was further increased in those patients with cardiac syndrome X who had also MS.
C1 [Cay, Serkan] Haydarpasa Educ Hosp, Gulhane Mil Med Acad, Dept Cardiol, Ankara, Turkey.
   [Demir, Bulent] Doctor Sadi KONUK Educ & Res Hosp, Dept Cardiol, Istanbul, Turkey.
   [Temizhan, Ahmet; Keskin, Gokhan; Baser, Kazim; Turak, Osman] Yuksek Ihtisas Educ & Res Hosp, Dept Cardiol, Ankara, Turkey.
C3 Gulhane Military Medical Academy; Istanbul Haydarpasa Sultan Abdulhamid
   Training & Research Hospital; Turkey Specialized Higher Education &
   Research Hospital; Yuksek Ihtisas Training & Research Hospital
RP Cay, S (corresponding author), Haydarpasa Educ Hosp, Gulhane Mil Med Acad, Dept Cardiol, Yasamkent Mah 3222 Cad 2 Blok Yakut 37 D 27 Cayyo, Ankara, Turkey.
EM cayserkan@yahoo.com
RI Demir, Bulent/KVC-1688-2024; Temizhan, Ahmet/AGR-9682-2022; Keskin,
   Gökhan/CAJ-0357-2022; Cay, Serkan/JVP-0508-2024
OI Demir, Bulent/0000-0003-1767-408X
CR [Anonymous], 2004, TOP 10 CAUS DEATH
   Breitling LP, 2010, ATHEROSCLEROSIS, V210, P649, DOI 10.1016/j.atherosclerosis.2009.12.037
   Cartier SG, 1999, TXB INTERVENTIONAL C, P748
   Cin VG, 2003, JPN HEART J, V44, P907, DOI 10.1536/jhj.44.907
   Costa-Hong V, 2009, ARQ BRAS CARDIOL, V92, P381
   Dagenais GR, 2002, CAN J CARDIOL, V18, P941
   Esposito K, 2004, NUTR METAB CARDIOVAS, V14, P228, DOI 10.1016/S0939-4753(04)80048-6
   Fox K, 2006, EUR HEART J, V27, P1341, DOI 10.1093/eurheartj/ehl001
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Jo SK, 2009, CLIN CHIM ACTA, V403, P234, DOI 10.1016/j.cca.2009.03.035
   Kappagoda CT, 2009, J CARDIOPULM REHABIL, V29, P207, DOI 10.1097/HCR.0b013e3181af6be5
   Kawamoto R, 2009, J ATHEROSCLER THROMB, V16, P355, DOI 10.5551/jat.No414
   Kemp H G, 1967, Trans Assoc Am Physicians, V80, P59
   Lee DH, 2004, FREE RADICAL RES, V38, P535, DOI 10.1080/10715760410001694026
   MARK DB, 1987, ANN INTERN MED, V106, P793, DOI 10.7326/0003-4819-106-6-793
   Mason Jennifer E, 2010, Prev Cardiol, V13, P36, DOI 10.1111/j.1751-7141.2009.00054.x
   MINTZ GS, 1995, J AM COLL CARDIOL, V25, P1479, DOI 10.1016/0735-1097(95)00088-L
   MORIYA S, 1994, ALCOHOL ALCOHOLISM, V29, P107
   Nakanishi N, 2003, J INTERN MED, V254, P287, DOI 10.1046/j.1365-2796.2003.01198.x
   Onat A, 2004, TURK KARDIYOLOJI DER, V32, P1
   Pekdemir H, 2004, ACTA CARDIOL, V59, P127, DOI 10.2143/AC.59.2.2005166
   Pizzi C, 2004, CIRCULATION, V109, P53, DOI 10.1161/01.CIR.0000100722.34034.E4
   Ruttmann E, 2005, CIRCULATION, V112, P2130, DOI 10.1161/CIRCULATIONAHA.105.552547
   Sen N, 2009, TURK KARDIYOL DERN A, V37, P168
   SPEARS JR, 1983, CIRCULATION, V68, P453, DOI 10.1161/01.CIR.68.2.453
   Stojakovic T, 2010, ATHEROSCLEROSIS, V208, P564, DOI 10.1016/j.atherosclerosis.2009.07.026
   Whitfield JB, 2001, CRIT REV CL LAB SCI, V38, P263, DOI 10.1080/20014091084227
NR 28
TC 14
Z9 14
U1 0
U2 3
PU VIA MEDICA
PI GDANSK
PA UL SWIETOKRZYSKA 73, 80-180 GDANSK, POLAND
SN 0022-9032
EI 1897-4279
J9 KARDIOL POL
JI Kardiol. Pol.
PD JAN
PY 2012
VL 70
IS 1
BP 31
EP 37
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 904BQ
UT WOS:000301169000010
PM 22267422
DA 2025-06-11
ER

PT J
AU Bouglé, D
   Brouard, J
AF Bougle, Dominique
   Brouard, Jacques
TI Iron in Child Obesity. Relationships with Inflammation and Metabolic
   Risk Factors
SO NUTRIENTS
LA English
DT Article
DE iron; obesity; children; inflammation; metabolic syndrome; non alcoholic
   fatty liver disease (NAFLD)
ID C-REACTIVE PROTEIN; INSULIN-RESISTANCE SYNDROME; SERUM FERRITIN; OBESE
   CHILDREN; MAJOR DETERMINANTS; OXIDATIVE STRESS; LIVER-DISEASE; FATTY
   LIVER; DEFICIENCY; WOMEN
AB Iron (Fe) sequestration is described in overweight and in its associated metabolic complications, i.e., metabolic syndrome (MetS) and non-alcoholic liver fatty disease (NAFLD); however, the interactions between Fe, obesity and inflammation make it difficult to recognize the specific role of each of them in the risk of obesity-induced metabolic diseases. Even the usual surrogate marker of Fe stores, ferritin, is influenced by inflammation; therefore, in obese subjects inflammation parameters must be measured together with those of Fe metabolism. This cross-sectional study in obese youth (502 patients; 57% girls): 11.4 +/- 3.0 years old (x +/- SD); BMI z score 5.5 +/- 2.3), multivariate regression analysis showed associations between Fe storage assessed by serum ferritin with risk factors for MetS and NAFLD, assessed by transaminase levels, which were independent of overweight and the acute phase protein fibrinogen. Further studies incorporating the measurement of complementary parameters of Fe metabolism could improve the comprehension of mechanisms involved.
C1 [Bougle, Dominique; Brouard, Jacques] CHU Caen, Dept Pediat, F-14033 Caen, France.
C3 CHU de Caen NORMANDIE; Universite de Caen Normandie
RP Bouglé, D (corresponding author), CHU Caen, Dept Pediat, F-14033 Caen, France.
EM dbougle@wanadoo.fr; brouard-jacques@chu-caen.fr
RI Brouard, Jacques/AAH-3387-2020
CR Ahmed U, 2012, WORLD J GASTROENTERO, V18, P4651, DOI 10.3748/wjg.v18.i34.4651
   Aigner E, 2008, AM J CLIN NUTR, V87, P1374, DOI 10.1093/ajcn/87.5.1374
   [Anonymous], 2001, Iron Deficiency Anaemia: Assessment, Prevention
   Anses, CHOIX EX MET FER CAS
   Baumgartner J, 2013, INT J OBESITY, V37, P24, DOI 10.1038/ijo.2012.145
   Brotanek JM, 2007, PEDIATRICS, V120, P568, DOI 10.1542/peds.2007-0572
   Brugnara C, 2013, CLIN CHEM, V59, P740, DOI 10.1373/clinchem.2012.182071
   Cepeda-Lopez AC, 2011, AM J CLIN NUTR, V93, P975, DOI 10.3945/ajcn.110.005439
   Cheng HL, 2012, OBES REV, V13, P150, DOI 10.1111/j.1467-789X.2011.00938.x
   Choi KM, 2005, METABOLISM, V54, P1510, DOI 10.1016/j.metabol.2005.05.018
   Cooper M., 2012, HLTH REP, V23, P3
   Datz C, 2013, EUR J CLIN INVEST, V43, P215, DOI 10.1111/eci.12032
   Dongiovanni P, 2011, J HEPATOL, V55, P920, DOI 10.1016/j.jhep.2011.05.008
   Dubern B, 2006, INT J PEDIATR OBES, V1, P77, DOI 10.1080/17477160600569594
   Engle-Stone R, 2013, J NUTR, V143, P369, DOI 10.3945/jn.112.167775
   Escobar-Morreale HF, 2003, DIABETOLOGIA, V46, P625, DOI 10.1007/s00125-003-1090-z
   Fernández-Real JM, 2005, CLIN CHEM, V51, P1201, DOI 10.1373/clinchem.2004.046847
   Ford ES, 2005, DIABETES CARE, V28, P878, DOI 10.2337/diacare.28.4.878
   Fumeron F, 2006, DIABETES CARE, V29, P2090, DOI 10.2337/dc06-0093
   Gabrielsen JS, 2012, J CLIN INVEST, V122, P3529, DOI 10.1172/JCI44421
   González AS, 2006, EUR J CLIN NUTR, V60, P802, DOI 10.1038/sj.ejcn.1602384
   Harrison-Findik DD, 2010, WORLD J HEPATOL, V2, P302, DOI 10.4254/wjh.v2.i8.302
   Hercberg S, 2001, Public Health Nutr, V4, P537
   Hiura M, 2003, HYPERTENS RES, V26, P541, DOI 10.1291/hypres.26.541
   Houschyar KS, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-54
   Jehn M, 2004, DIABETES CARE, V27, P2422, DOI 10.2337/diacare.27.10.2422
   Kowdley KV, 2012, HEPATOLOGY, V55, P77, DOI 10.1002/hep.24706
   Lecube A, 2008, INT J OBESITY, V32, P1665, DOI 10.1038/ijo.2008.154
   Mandato C, 2005, J PEDIATR-US, V147, P62, DOI 10.1016/j.jpeds.2005.02.028
   Moayeri H, 2006, EUR J PEDIATR, V165, P813, DOI 10.1007/s00431-006-0178-0
   Moschonis G, 2012, BRIT J NUTR, V108, P710, DOI 10.1017/S0007114511005952
   Nead KG, 2004, PEDIATRICS, V114, P104, DOI 10.1542/peds.114.1.104
   Neuschwander-Tetri BA, 2007, CURR OPIN GASTROEN, V23, P193, DOI 10.1097/MOG.0b013e32801421a9
   Pinhas-Hamiel O, 2003, INT J OBESITY, V27, P416, DOI 10.1038/sj.ijo.0802224
   Richardson MW, 2009, INT J PEDIATR ENDOCR, DOI 10.1155/2009/713269
   ROLLANDCACHERA MF, 1991, EUR J CLIN NUTR, V45, P13
   Skinner AC, 2010, PEDIATRICS, V125, pE801, DOI 10.1542/peds.2009-2182
   Sumida Y, 2006, HEPATOL RES, V36, P315, DOI 10.1016/j.hepres.2006.08.003
   Sun L, 2008, J CLIN ENDOCR METAB, V93, P4690, DOI 10.1210/jc.2008-1159
   Syrovatka P, 2009, ANN NUTR METAB, V54, P268, DOI 10.1159/000229507
   Tussing-Humphreys L, 2012, J ACAD NUTR DIET, V112, P391, DOI 10.1016/j.jada.2011.08.038
   Tussing-Humphreys LM, 2009, J AM DIET ASSOC, V109, P297, DOI 10.1016/j.jada.2008.10.044
   Valenti L, 2011, NUTR METAB CARDIOVAS, V21, P568, DOI 10.1016/j.numecd.2010.01.003
   Whaley-Connell A, 2011, REV CARDIOVASC MED, V12, P21, DOI 10.3909/ricm0555
   Wrede CE, 2006, EUR J ENDOCRINOL, V154, P333, DOI 10.1530/eje.1.02083
   Zelber-Sagi S, 2007, J HEPATOL, V46, P700, DOI 10.1016/j.jhep.2006.09.018
NR 46
TC 21
Z9 22
U1 0
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2013
VL 5
IS 6
BP 2222
EP 2230
DI 10.3390/nu5062222
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 169HS
UT WOS:000320771400023
PM 23783556
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Frühbeck, G
   Catalán, V
   Rodríguez, A
   Ramírez, B
   Becerril, S
   Salvador, J
   Portincasa, P
   Colina, I
   Gómez-Ambrosi, J
AF Fruhbeck, Gema
   Catalan, Victoria
   Rodriguez, Amaia
   Ramirez, Beatriz
   Becerril, Sara
   Salvador, Javier
   Portincasa, Piero
   Colina, Inmaculada
   Gomez-Ambrosi, Javier
TI Involvement of the leptin-adiponectin axis in inflammation and oxidative
   stress in the metabolic syndrome
SO SCIENTIFIC REPORTS
LA English
DT Article
ID SERUM AMYLOID-A; CARDIOMETABOLIC RISK-FACTORS; C-REACTIVE PROTEIN;
   INSULIN-RESISTANCE; ADIPOSE-TISSUE; INDEPENDENT PREDICTORS; KEY PLAYER;
   OBESITY; OSTEOPONTIN; PLASMA
AB The aim of the present work was to study whether the leptin-adiponectin axis may have a pathophysiological role in the increased systemic inflammation and oxidative stress observed in patients with the metabolic syndrome (MS). Leptin, adiponectin, and markers of inflammation and oxidative stress were measured in a sample of 140 Caucasian subjects (74 males/66 females), aged 28-82 years, 60 with and 80 without the MS. Total concentrations of adiponectin as well as its multimeric forms HMW, MMW and LMW were significantly lower in individuals with the MS. The ratio adiponectin/leptin, a marker of dysfunctional adipose tissue, was dramatically decreased in the MS group. Systemic oxidative stress, as evidenced by levels of thiobarbituric acid reactive substances (TBARS), as well as markers of inflammation such as serum amyloid A (SAA), C-reactive protein (CRP) and osteopontin were significantly increased in subjects with the MS. Total adiponectin concentrations were negatively correlated with levels of TBARS and CRP levels. Furthermore, the ratio adiponectin/leptin was negatively correlated with SAA concentrations as well as with CRP levels. We concluded that a dysfunctional adipose tissue as suggested by a low adiponectin/leptin ratio may contribute to the increased oxidative stress and inflammation, hallmarks of the MS.
C1 [Fruhbeck, Gema; Catalan, Victoria; Rodriguez, Amaia; Ramirez, Beatriz; Becerril, Sara; Gomez-Ambrosi, Javier] Clin Univ Navarra, Metab Res Lab, Pamplona, Spain.
   [Fruhbeck, Gema; Catalan, Victoria; Rodriguez, Amaia; Ramirez, Beatriz; Becerril, Sara; Salvador, Javier; Gomez-Ambrosi, Javier] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Pamplona, Spain.
   [Fruhbeck, Gema; Catalan, Victoria; Rodriguez, Amaia; Ramirez, Beatriz; Becerril, Sara; Colina, Inmaculada; Gomez-Ambrosi, Javier] Inst Invest Sanitaria Navarra IdiSNA, Obes & Adipobiol Grp, Pamplona, Spain.
   [Fruhbeck, Gema; Salvador, Javier] Clin Univ Navarra, Dept Endocrinol & Nutr, Pamplona, Spain.
   [Portincasa, Piero] Univ Bari, Med Sch, Policlin Hosp, Dept Biomed Sci & Human Oncol,Clin Med A Murri, Bari, Italy.
   [Colina, Inmaculada] Clin Univ Navarra, Dept Internal Med, Pamplona, Spain.
C3 University of Navarra; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; University of Navarra;
   Universita degli Studi di Bari Aldo Moro; University of Navarra
RP Gómez-Ambrosi, J (corresponding author), Clin Univ Navarra, Metab Res Lab, Pamplona, Spain.; Gómez-Ambrosi, J (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Pamplona, Spain.; Gómez-Ambrosi, J (corresponding author), Inst Invest Sanitaria Navarra IdiSNA, Obes & Adipobiol Grp, Pamplona, Spain.
RI portincasa, piero/J-7245-2018; Rodríguez, Amaia/D-3044-2019;
   Gómez-Ambrosi, Javier/D-2984-2017; Ramírez, Beatriz/I-1922-2017;
   Catalan, Victoria/H-3566-2017
OI Catalan, Victoria/0000-0002-7513-7509
FU FIS [PI13/00460, PI14/00950, PI16/01217]; Spanish Instituto de Salud
   Carlos III-Subdireccion General de Evaluacion y Fomento de la
   investigacion-FEDER; Centro de Investigacion Biomedica en Red
   Fisiopatologia de la Obesidad y Nutricion, CIBEROBN, ISCIII, Spain
FX The authors thank all the individuals who participated in this study.
   This work was supported by the project grants FIS PI13/00460, PI14/00950
   and PI16/01217, integrated in the Plan Estatal I + D + I 2013-16 from
   the Spanish Instituto de Salud Carlos III-Subdireccion General de
   Evaluacion y Fomento de la investigacion-FEDER and by Centro de
   Investigacion Biomedica en Red Fisiopatologia de la Obesidad y
   Nutricion, CIBEROBN, ISCIII, Spain.
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Angulo P, 1999, HEPATOLOGY, V30, P1356, DOI 10.1002/hep.510300604
   Blüher M, 2015, METABOLISM, V64, P131, DOI 10.1016/j.metabol.2014.10.016
   Bonomini F, 2015, AGING DIS, V6, P109, DOI 10.14336/AD.2014.0305
   Catalán V, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0162189
   Crewe C, 2017, J CLIN INVEST, V127, P74, DOI 10.1172/JCI88883
   Delporte ML, 2004, AM J PHYSIOL-ENDOC M, V287, pE446, DOI 10.1152/ajpendo.00488.2003
   Frühbeck G, 2001, FASEB J, V15, P1996, DOI 10.1096/fj.00-0829hyp
   Frühbeck G, 2003, DIABETOLOGIA, V46, P143, DOI 10.1007/s00125-003-1053-4
   Frühbeck G, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-02848-0
   Furukawa S., 2004, Journal of Clinical Investigation, V114, P1752, DOI 10.1172/JCI21625
   Gómez-Ambrosi J, 2006, OBES SURG, V16, P262, DOI 10.1381/096089206776116525
   Gómez-Ambrosi J, 2012, INT J OBESITY, V36, P286, DOI 10.1038/ijo.2011.100
   Gómez-Ambrosi J, 2002, CLIN BIOCHEM, V35, P315, DOI 10.1016/S0009-9120(02)00320-X
   Gómez-Ambrosi J, 2007, J CLIN ENDOCR METAB, V92, P3719, DOI 10.1210/jc.2007-0349
   Gómez-Ambrosi J, 2014, DIABETES CARE, V37, P2813, DOI 10.2337/dc14-0937
   Gómez-Ambrosi J, 2012, DIABETES CARE, V35, P383, DOI 10.2337/dc11-1334
   Hara K, 2006, DIABETES CARE, V29, P1357, DOI 10.2337/dc05-1801
   Inoue M, 2006, METABOLISM, V55, P1248, DOI 10.1016/j.metabol.2006.05.010
   Kadowaki T, 2006, J CLIN INVEST, V116, P1784, DOI 10.1172/JCI29126
   Kahles F, 2014, MOL METAB, V3, P384, DOI 10.1016/j.molmet.2014.03.004
   Klöting N, 2014, REV ENDOCR METAB DIS, V15, P277, DOI 10.1007/s11154-014-9301-0
   Lancha A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0098398
   Lancha A, 2012, NUTR RES REV, V25, P223, DOI 10.1017/S0954422412000145
   Yubero-Serrano EM, 2013, EXP MOL MED, V45, DOI 10.1038/emm.2013.53
   Marseglia L, 2015, INT J MOL SCI, V16, P378, DOI 10.3390/ijms16010378
   Mirhafez SR, 2016, EUR J CLIN NUTR, V70, P1298, DOI 10.1038/ejcn.2016.111
   Otani H, 2011, ANTIOXID REDOX SIGN, V15, P1911, DOI 10.1089/ars.2010.3739
   Poitou C, 2005, DIABETOLOGIA, V48, P519, DOI 10.1007/s00125-004-1654-6
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Rodríguez A, 2007, CURR PHARM DESIGN, V13, P2169
   Sáinz N, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006808
   Scheid MP, 2014, REV ENDOCR METAB DIS, V15, P157, DOI 10.1007/s11154-013-9265-5
   SCHERER PE, 1995, J BIOL CHEM, V270, P26746, DOI 10.1074/jbc.270.45.26746
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Stepanova M, 2010, GUT, V59, P1410, DOI 10.1136/gut.2010.213553
   Suzuki T, 2014, DIABETES CARE, V37, P2284, DOI 10.2337/dc13-2059
   Tardelli M, 2016, MOL METAB, V5, P1131, DOI 10.1016/j.molmet.2016.09.003
   Vega GL, 2013, J OBES, V2013, DOI 10.1155/2013/409679
   Yadav D, 2015, OBES RES CLIN PRACT, V9, P158, DOI 10.1016/j.orcp.2014.03.004
   Yamauchi T, 2008, INT J OBESITY, V32, pS13, DOI 10.1038/ijo.2008.233
   Yamauchi T, 2013, CELL METAB, V17, P185, DOI 10.1016/j.cmet.2013.01.001
   Yang RZ, 2006, PLOS MED, V3, P884, DOI 10.1371/journal.pmed.0030287
   Zimmet P, 1999, ANN NY ACAD SCI, V892, P25, DOI 10.1111/j.1749-6632.1999.tb07783.x
NR 44
TC 146
Z9 152
U1 0
U2 12
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUL 26
PY 2017
VL 7
AR 6619
DI 10.1038/s41598-017-06997-0
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FB8CL
UT WOS:000406366400027
PM 28747790
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Brugnera, A
   Compare, A
   Omboni, S
   Greco, A
   Carrara, S
   Tasca, GA
   Poletti, B
   Parati, G
AF Brugnera, Agostino
   Compare, Angelo
   Omboni, Stefano
   Greco, Andrea
   Carrara, Silvia
   Tasca, Giorgio Angelo
   Poletti, Barbara
   Parati, Gianfranco
TI Psychological Covariates of Blood Pressure Among Patients With
   Hypertension and Metabolic Syndrome
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE blood pressure; depression; hypertension; quality of life; well-being
ID QUALITY-OF-LIFE; EUROPEAN-SOCIETY; ARTERIAL-HYPERTENSION; PSYCHOSOCIAL
   STRESS; PRACTICE GUIDELINES; HEALTH INTERVIEW; RISK; DEPRESSION;
   METAANALYSIS; ASSOCIATION
AB Objective: Previous research provides support for the role of psychosocial variables in the progression of hypertension. However, few studies have rigorously tested the longitudinal interplay between blood pressure and depressive symptoms, quality of life, and well-being. Fewer still disaggregate the effects of changes of these psychological variables within patients over time from the effects of differences between patients on essential hypertension. Method: A total of 185 patients with hypertension and metabolic syndrome (130 males, 70.3%; mean age 54 +/- 10.93 years) volunteered for this multicentre study. We analyzed the longitudinal associations between office or daytime ambulatory blood pressure with depressive symptoms, well-being, and quality of life, measured at the same three time points (baseline and 36- and 48-week follow-up), through multilevel models and controlling for several sociodemographic and clinical factors. Results: Within-person increases in depressive symptoms were significant, positive time-varying covariates of both office and daytime blood pressure, even after controlling for several potential confounders (e.g., age, sex, changes over time in risk factors for metabolic syndrome). Within-person increases in well-being and mental health components of quality of life had similar negative associations with the level of blood pressure over time. Between-person differences in these variables tended not to predict blood pressure. Conclusions: Our findings provide a deeper insight on the relationship between variability of psychological variables within individuals and their levels of blood pressure. The findings support the need for health services to implement evidence-based psychological interventions that can foster a better management of the hypertensive disease.
C1 [Brugnera, Agostino; Compare, Angelo; Greco, Andrea; Carrara, Silvia] Univ Bergamo, Dept Human & Social Sci, Ple S Agostino 2, I-24129 Bergamo, Italy.
   [Omboni, Stefano] Sechenov First Moscow State Med Univ, Dept Cardiol, Moscow, Russia.
   [Tasca, Giorgio Angelo] Univ Ottawa, Sch Psychol, Ottawa, ON, Canada.
   [Poletti, Barbara] IRCCS, Dept Neurol, Ist Auxol Italiano, Milan, Italy.
   [Poletti, Barbara] IRCCS, Lab Neurosci, Ist Auxol Italiano, Milan, Italy.
   [Parati, Gianfranco] Univ Milano Bicocca, Sch Med & Surg, Milan, Italy.
   [Parati, Gianfranco] IRCCS, Dept Cardiovasc Neural & Metab Sci, San Luca Hosp, Ist Auxol Italiano, Milan, Italy.
C3 University of Bergamo; Sechenov First Moscow State Medical University;
   University of Ottawa; IRCCS Istituto Auxologico Italiano; IRCCS Istituto
   Auxologico Italiano; University of Milano-Bicocca; IRCCS Istituto
   Auxologico Italiano
RP Brugnera, A (corresponding author), Univ Bergamo, Dept Human & Social Sci, Ple S Agostino 2, I-24129 Bergamo, Italy.
EM agostino.brugnera@unibg.it
RI Carrara, Silvia/AAC-5298-2022; Tasca, Giorgio/AAG-1867-2019; Poletti,
   Barbara/W-6917-2019; Greco, Andrea/I-7266-2016; Poletti,
   Barbara/K-9332-2016; Compare, Prof. Angelo/H-3519-2014; Omboni,
   Stefano/D-1327-2015; Parati, Gianfranco/K-7151-2016
OI Greco, Andrea/0000-0002-8086-2801; Brugnera,
   Agostino/0000-0002-4066-4552; Poletti, Barbara/0000-0003-4398-2051;
   Compare, Prof. Angelo/0000-0002-3336-7920; Omboni,
   Stefano/0000-0002-7124-2096; Parati, Gianfranco/0000-0001-9402-7439
FU Bracco S.p.A.
FX This work was financially supported by Bracco S.p.A. through an
   unconditional and unrestricted grant.
CR al'Absi M, 2000, BIOMED PHARMACOTHER, V54, P234, DOI 10.1016/S0753-3322(00)80065-7
   American Psychiatric Association, 2000, spectrum disorders using the current DSM-IV-TR diagnostic, V4th, DOI 10.1176/dsm10.1176/appi.books.9780890420249.dsm-iv-tr
   [Anonymous], 1995, RAND 36 IT HLTH SURV
   Beck A. T., 1996, BDI 2 BECK DEPRESSIO
   Berendes A, 2013, PSYCHOSOM MED, V75, P422, DOI 10.1097/PSY.0b013e31828ef0c2
   Cohen J., 1988, STAT POWER ANAL BEHA, DOI [10.4324/9780203771587, DOI 10.4324/9780203771587]
   Cuevas AG, 2017, CARDIOL CLIN, V35, P223, DOI 10.1016/j.ccl.2016.12.004
   Cuffee Y, 2014, CURR HYPERTENS REP, V16, DOI 10.1007/s11906-014-0483-3
   Davydov D. M., 2015, INT ENCY SOC BEHAV S, V11, P453, DOI DOI 10.1016/13978-0-08-097086-8.14104-2
   Dupuy H., 1984, ASSESSMENT QUALITY L, P170
   Everson SA, 1998, PSYCHOSOM MED, V60, P730, DOI 10.1097/00006842-199811000-00014
   Footman K, 2013, J PUBLIC HEALTH-UK, V35, P548, DOI 10.1093/pubmed/fdt019
   Grewen KM, 2004, PSYCHOSOM MED, V66, P9, DOI 10.1097/01.PSY.0000106881.60228.16
   Grossi E., 2014, Encyclopedia of Quality of Life and Well-Being Research, DOI 10.1007/978-94-007-0753-5_2309
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Hamer M, 2010, HYPERTENSION, V56, P547, DOI 10.1161/HYPERTENSIONAHA.110.153775
   Hildingh C, 2010, SCAND J CARING SCI, V24, P366, DOI 10.1111/j.1471-6712.2009.00730.x
   Jackson CA, 2016, J HYPERTENS, V34, P1959, DOI 10.1097/HJH.0000000000001030
   Jonas BS, 2000, PSYCHOSOM MED, V62, P188, DOI 10.1097/00006842-200003000-00006
   Katsi V, 2017, FRONT PSYCHIATRY, V8, DOI 10.3389/fpsyt.2017.00270
   Kjeldsen SE, 2018, PHARMACOL RES, V129, P95, DOI 10.1016/j.phrs.2017.11.003
   Kubzansky LD, 2018, J AM COLL CARDIOL, V72, P1382, DOI 10.1016/j.jacc.2018.07.042
   Kuo PL, 2011, J HYPERTENS, V29, P2084, DOI 10.1097/HJH.0b013e32834b59ad
   Lambert EA, 2011, CURR HYPERTENS REP, V13, P244, DOI 10.1007/s11906-011-0186-y
   Li ZZ, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000001317
   Liu MY, 2017, NEUROL RES, V39, P573, DOI 10.1080/01616412.2017.1317904
   Long J, 2015, J HUM HYPERTENS, V29, P478, DOI 10.1038/jhh.2014.112
   Luft FC, 2001, HYPERTENSION, V37, P350, DOI 10.1161/01.HYP.37.2.350
   Magrin ME, 2015, ANN BEHAV MED, V49, P307, DOI 10.1007/s12160-014-9663-2
   Mancia G, 2013, J HYPERTENS, V31, P1925, DOI 10.1097/HJH.0b013e328364ca4c
   Meng L, 2012, J HYPERTENS, V30, P842, DOI 10.1097/HJH.0b013e32835080b7
   Ojike N, 2016, CARDIORENAL MED, V6, P198, DOI 10.1159/000443933
   Olszanecka-Glinianowicz M, 2014, J HYPERTENS, V32, P397, DOI 10.1097/HJH.0000000000000046
   Pan Y, 2015, NEUROPSYCH DIS TREAT, V11, P1121, DOI 10.2147/NDT.S77710
   Parati G, 2014, J HYPERTENS, V32, P1359, DOI 10.1097/HJH.0000000000000221
   Parati G, 2013, TRIALS, V14, DOI 10.1186/1745-6215-14-22
   Rafanelli C, 2012, PSYCHIAT RES, V198, P154, DOI 10.1016/j.psychres.2011.09.014
   Raudenbush S. W., 2002, Hierarchical linear models: Applications and data analysis methods
   RUTLEDGE T, 2002, PSYCHOSOM MED
   Scalco Andréia Zavaloni, 2005, Clinics, V60, P241, DOI 10.1590/S1807-59322005000300010
   Silva Gustavo O., 2020, Int. J. Cardiovasc. Sci., V33, P133, DOI 10.5935/2359-4802.20190092
   Sparrenberger Felipe, 2008, BMC Public Health, V8, P357, DOI 10.1186/1471-2458-8-357
   Spruill TM, 2010, CURR HYPERTENS REP, V12, P10, DOI 10.1007/s11906-009-0084-8
   Steptoe A, 2005, NEUROBIOL AGING, V26, pS108, DOI 10.1016/j.neurobiolaging.2005.08.016
   Timmis A, 2020, EUR HEART J, V41, P12, DOI 10.1093/eurheartj/ehz859
   Trevisol DJ, 2011, J HYPERTENS, V29, P179, DOI 10.1097/HJH.0b013e328340d76f
   Trudel-Fitzgerald C, 2015, CURR HYPERTENS REP, V17, DOI 10.1007/s11906-015-0605-6
   Trudel-Fitzgerald C, 2014, J HYPERTENS, V32, P1222, DOI 10.1097/HJH.0000000000000175
   Van der Kooy K, 2007, INT J GERIATR PSYCH, V22, P613, DOI 10.1002/gps.1723
   WARE JE, 1992, MED CARE, V30, P473, DOI 10.1097/00005650-199206000-00002
   Williams B, 2018, J HYPERTENS, V36, P2284, DOI [10.1097/HJH.0000000000001961, 10.1097/HJH.0000000000002026]
   Wu EL, 2012, J PSYCHOSOM RES, V73, P169, DOI 10.1016/j.jpsychores.2012.07.002
   Zhong ZY, 2017, NEUROPSYCH DIS TREAT, V13, P2781, DOI 10.2147/NDT.S141832
   Zhou B, 2017, LANCET, V389, P37, DOI 10.1016/S0140-6736(16)31919-5
NR 54
TC 5
Z9 5
U1 0
U2 8
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD DEC
PY 2022
VL 41
IS 12
BP 946
EP 954
DI 10.1037/hea0001205
EA JUL 2022
PG 9
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA 6G0ZB
UT WOS:000827799500001
PM 35862126
DA 2025-06-11
ER

PT J
AU Nyboe, L
   Vestergaard, CH
   Lund, H
   Moller, MK
   Videbech, P
AF Nyboe, L.
   Vestergaard, C. H.
   Lund, H.
   Moller, M. K.
   Videbech, P.
TI Metabolic syndrome in first-time hospitalized patients with depression:
   a 1-year follow-up study
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE depression; metabolic syndrome; aerobic fitness; antipsychotics
ID MAJOR DEPRESSION; PHYSICAL-ACTIVITY; CARDIORESPIRATORY FITNESS; EXCESS
   MORTALITY; MOOD DISORDERS; LIFE-STYLE; METAANALYSIS; ANXIETY; RISK;
   SCHIZOPHRENIA
AB ObjectiveStudies on metabolic syndrome (MetS) in younger patients with depression are few. We examined the prevalence and progression of MetS in first-time hospitalized patients with depression during 1year of follow-up. Furthermore, we explored putative risk factors of MetS.
   MethodWe evaluated MetS and its components in first-time hospitalized patients with depression (N=52) and healthy controls (N=50) (18-45years). Physical activity, aerobic fitness, sleeping disturbances, smoking and dietary habits, and psychopharmacological treatment were recorded at baseline for all participants and after 1year for the patients.
   ResultsPatients had significantly higher waist circumference (WC) and lower high-density lipoproteins compared with healthy controls (P<0.05). Patients had higher prevalence of MetS, but this was not significant when adjusted for age. Patients had significant increase in WC and triglycerides and a non-significant increase in the prevalence of MetS. Antipsychotic medication (OR 10.5, 95% CI 1.18-94.14) and low aerobic fitness (OR 0.79, 95% CI 0.68-0.93) were significantly correlated with MetS (P<0.05).
   ConclusionMetabolic syndrome is highly prevalent in younger, severely depressed patients and the incidence increases during 1year of follow-up. Low aerobic fitness and use of atypical antipsychotics are strongly correlated with MetS.
C1 [Nyboe, L.; Vestergaard, C. H.; Videbech, P.] Aarhus Univ Hosp Risskov, Res Unit, Dept Affect Disorders Q, Skovagervej 2, DK-8240 Risskov, Denmark.
   [Lund, H.] Univ Southern Denmark, Dept Sports Sci & Clin Biomech, Res Unit Musculoskeletal Funct & Physiotherapy, SEARCH Res Grp Synth Evidence & Res, Odense, Denmark.
   [Lund, H.] Bergen Univ Coll, Ctr Evidence Based Practice, Bergen, Norway.
   [Moller, M. K.] Horsens Reg Hosp, Dept Med, Horsens, Denmark.
C3 Aarhus University; University of Southern Denmark; Western Norway
   University of Applied Sciences
RP Nyboe, L (corresponding author), Aarhus Univ Hosp Risskov, Res Unit, Dept Affect Disorders Q, Skovagervej 2, DK-8240 Risskov, Denmark.
EM lene.nyboe@ps.rm.dk
RI Lund, Hans/HWT-2338-2023; Videbech, Poul/B-1924-2008; Lund,
   Hans/E-4075-2013
OI Videbech, Poul/0000-0003-0127-4348; Nyboe, Lene/0000-0001-7131-3010;
   Lund, Hans/0000-0001-6847-8324; Vestergaard, Claus
   Hostrup/0000-0003-2916-1548
FU Psychiatric Research Fund, Central Region of Denmark; Lundbeck Fund;
   Danish Physical Therapy Federation
FX The study was funded by The Psychiatric Research Fund, Central Region of
   Denmark, The Lundbeck Fund, and the Danish Physical Therapy Federation.
CR Aadahl M, 2003, MED SCI SPORT EXER, V35, P1196, DOI 10.1249/01.MSS.0000074446.02192.14
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Andersen LG, 2010, SCAND J PUBLIC HEALT, V38, P707, DOI 10.1177/1403494810380099
   Andersson C, 2014, AM HEART J, V168, P878, DOI 10.1016/j.ahj.2014.08.007
   ASTRAND I, 1960, Acta Physiol Scand Suppl, V49, P1
   Berk M, 2013, ACTA PSYCHIAT SCAND, V127, P38, DOI 10.1111/acps.12124
   Boettger S, 2009, PSYCHOSOM MED, V71, P519, DOI 10.1097/PSY.0b013e3181a55303
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1016/0165-1781(89)90047-4
   Cuijpers P, 2002, J AFFECT DISORDERS, V72, P227, DOI 10.1016/S0165-0327(01)00413-X
   Hert M, 2012, NAT REV ENDOCRINOL, V8, P114, DOI 10.1038/nrendo.2011.156
   Dortland AKBV, 2010, ACTA PSYCHIAT SCAND, V122, P30, DOI 10.1111/j.1600-0447.2010.01565.x
   Dortland AKBV, 2013, PSYCHOSOM MED, V75, P83, DOI 10.1097/PSY.0b013e318274d30f
   Duncan GE, 2001, PREV MED, V33, P18, DOI 10.1006/pmed.2001.0847
   Eriksen L, 2011, SCAND J PUBLIC HEALT, V39, P203, DOI 10.1177/1403494810393557
   Foley DL, 2010, TWIN RES HUM GENET, V13, P347, DOI 10.1375/twin.13.4.347
   Hildrum B, 2009, ACTA PSYCHIAT SCAND, V120, P14, DOI 10.1111/j.1600-0447.2008.01315.x
   Huang YJ, 2014, EUR J MED RES, V19, DOI 10.1186/2047-783X-19-22
   Hung CI, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/1471-244X-14-185
   Kahl KG, 2014, ACTA PSYCHIAT SCAND, V130, P137, DOI 10.1111/acps.12242
   Kahl KG, 2012, EUR ARCH PSY CLIN N, V262, P313, DOI 10.1007/s00406-011-0277-4
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Lakka TA, 2003, MED SCI SPORT EXER, V35, P1279, DOI 10.1249/01.MSS.0000079076.74931.9A
   Leas L, 2007, J HEALTH PSYCHOL, V12, P563, DOI 10.1177/1359105307078162
   Lehto SM, 2008, PROG NEURO-PSYCHOPH, V32, P1557, DOI 10.1016/j.pnpbp.2008.05.021
   Lin CC, 2012, PSYCHIAT RES, V197, P322, DOI 10.1016/j.psychres.2011.09.012
   Luppino FS, 2014, GEN HOSP PSYCHIAT, V36, P509, DOI 10.1016/j.genhosppsych.2014.05.018
   Maes M, 1997, ACTA PSYCHIAT SCAND, V95, P212, DOI 10.1111/j.1600-0447.1997.tb09622.x
   Marazziti D, 2014, CNS SPECTRUMS, V19, P293, DOI 10.1017/S1092852913000667
   McIntyre RS, 2012, ANN CLIN PSYCHIATRY, V24, P69
   McIntyre RS, 2010, CNS DRUGS, V24, P741, DOI 10.2165/11533280-000000000-00000
   McIntyre RS, 2009, CURR DIABETES REP, V9, P51, DOI 10.1007/s11892-009-0010-0
   Minder CM, 2014, AM J CARDIOL, V113, P637, DOI 10.1016/j.amjcard.2013.11.010
   Morrell JS, 2013, METAB SYNDR RELAT D, V11, P370, DOI 10.1089/met.2013.0011
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Myers J, 2015, PROG CARDIOVASC DIS, V57, P306, DOI 10.1016/j.pcad.2014.09.011
   Nielsen J, 2010, NEUROPSYCHOPHARMACOL, V35, P1997, DOI 10.1038/npp.2010.78
   Nyboe L, 2013, NORD J PSYCHIAT, V67, P43, DOI 10.3109/08039488.2012.675588
   Ösby U, 2001, ARCH GEN PSYCHIAT, V58, P844, DOI 10.1001/archpsyc.58.9.844
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Rosenbaum S, 2015, ACTA PSYCHIAT SCAND, V131, P234, DOI 10.1111/acps.12350
   Schuch FB, 2011, J AFFECT DISORDERS, V133, P615, DOI 10.1016/j.jad.2011.04.030
   Smith L.C., 2012, J CLIN LIPIDOLOGY, V6, P268
   Taylor V, 2010, CAN J PSYCHIAT, V55, P362, DOI 10.1177/070674371005500605
   Vancampfort D, 2015, ACTA PSYCHIAT SCAND, V132, P131, DOI 10.1111/acps.12407
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vanhala M, 2009, ACTA PSYCHIAT SCAND, V119, P137, DOI 10.1111/j.1600-0447.2008.01283.x
   Vishram J K., 2014, PLoS ONE, V9, P1
   WHO, 1993, The ICD-10 Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research
   Wulsin LR, 1999, PSYCHOSOM MED, V61, P6, DOI 10.1097/00006842-199901000-00003
NR 49
TC 8
Z9 10
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
EI 1600-0447
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD MAR
PY 2016
VL 133
IS 3
BP 241
EP 248
DI 10.1111/acps.12470
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DD7BF
UT WOS:000370078000009
PM 26251964
DA 2025-06-11
ER

PT J
AU Hoogervorst, MM
   van Meijel, B
   Krijnen-de Bruin, E
   Beekman, A
   Boonstra, N
   Adriaanse, M
AF Hoogervorst, Meike M.
   van Meijel, Berno
   Krijnen-de Bruin, Esther
   Beekman, Aartjan
   Boonstra, Nynke
   Adriaanse, Marcel
TI The nurse-led GILL eHealth intervention for improving physical health
   and lifestyle behaviours in clients with severe mental illness: design
   of a cluster-randomised controlled trial
SO BMC PSYCHIATRY
LA English
DT Article
DE Severe mental illness; Somatic screening; eHealth intervention;
   Lifestyle behaviours; RCT; Process evaluation; Metabolic syndrome
ID PSYCHOMETRIC PROPERTIES; METABOLIC SYNDROME; TRAINING NEEDS; PEOPLE;
   CARE; SCHIZOPHRENIA; QUESTIONNAIRE; PREVALENCE; DISORDERS; MORTALITY
AB BackgroundClients with severe mental illness (SMI) have overall poor physical health. SMI reduces life expectancy by 5-17 years, primarily due to physical comorbidity linked to cardiometabolic risks that are mainly driven by unhealthy lifestyle behaviours. To improve physical health in clients with SMI, key elements are systematic somatic screening and lifestyle promotion. The nurse-led GILL eHealth was developed for somatic screening and the implementation of lifestyle activities in clients with SMI. Aims of this study are to evaluate the effectiveness of the GILL eHealth intervention in clients with SMI compared to usual care, and to evaluate the implementation process, and the experiences of clients and healthcare providers with GILL eHealth.MethodsThe GILL study encompasses a cluster-randomised controlled trial in approximately 20 mental health care facilities in the Netherlands. The randomisation takes place at the team level, assigning clients to the eHealth intervention or the usual care group. The GILL eHealth intervention consists of two complementary modules for somatic screening and lifestyle promotion, resulting in personalised somatic treatment and lifestyle plans. Trained mental health nurses and nurse practitioners will implement the intervention within the multidisciplinary treatment context, and will guide and support the participants in promoting their physical health, including cardiometabolic risk management. Usual care includes treatment as currently delivered, with national guidelines as frame of reference. We aim to include 258 clients with SMI and a BMI of 27 or higher. Primary outcome is the metabolic syndrome severity score. Secondary outcomes are physical health measurements and participants' reports on physical activity, perceived lifestyle behaviours, quality of life, recovery, psychosocial functioning, and health-related self-efficacy. Measurements will be completed at baseline and at 6 and 12 months. A qualitative process evaluation will be conducted alongside, to evaluate the process of implementation and the experiences of clients and healthcare professionals with GILL eHealth.DiscussionThe GILL eHealth intervention is expected to be more effective than usual care in improving physical health and lifestyle behaviours among clients with SMI. It will also provide important information on implementation of GILL eHealth in mental health care. If proven effective, GILL eHealth offers a clinically useful tool to improve physical health and lifestyle behaviours.Trial registrationClinical trial registration NCT05533749, registration date: 8 September 2022.
C1 [Hoogervorst, Meike M.; van Meijel, Berno; Beekman, Aartjan; Adriaanse, Marcel] Amsterdam UMC, Dept Psychiat, Amsterdam, Netherlands.
   [Hoogervorst, Meike M.; van Meijel, Berno; Beekman, Aartjan] Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands.
   [van Meijel, Berno; Krijnen-de Bruin, Esther] Inholland Univ Appl Sci, Dept Hlth Sports & Welf, Amsterdam, Netherlands.
   [van Meijel, Berno] Parnassia Acad, Parnassia Psychiat Inst, The Hague, Netherlands.
   [Boonstra, Nynke] Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Dept Psychiat, Utrecht, Netherlands.
   [Boonstra, Nynke] Univ Appl Sci, NHL Stenden, Leeuwarden, Netherlands.
   [Boonstra, Nynke] KieN VIP Mental Hlth Care Serv, Leeuwarden, Netherlands.
   [Adriaanse, Marcel] Vrije Univ Amsterdam, Dept Hlth Sci, Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; University of Amsterdam; Vrije
   Universiteit Amsterdam; Parnassia Psychiatric Institute; Utrecht
   University; Utrecht University Medical Center; NHL Stenden University of
   Applied Sciences; Vrije Universiteit Amsterdam
RP Hoogervorst, MM (corresponding author), Amsterdam UMC, Dept Psychiat, Amsterdam, Netherlands.
EM m.m.hoogervorst@amsterdamumc.nl
RI Beekman, Aartjan T./LUZ-6919-2024; Adriaanse, Marieke/AFQ-8371-2022
OI Adriaanse, Marcel/0000-0002-5085-6662; Boonstra,
   Nynke/0000-0003-3592-1953
FU Netherlands Organisation for Health Research and Development, ZonMw
   [10040022010002]; Amsterdam University Medical Centre
FX This study was supported by a grant from the Netherlands Organisation
   for Health Research and Development, ZonMw (grant no. 10040022010002).
   The funder had no role in the design or execution of the study, data
   collection, analysis and interpretation, decision to publish, or writing
   of the manuscript. The Amsterdam University Medical Centre is the
   sponsor of this study.
CR Ashbeck EL, 2016, BMC MED RES METHODOL, V16, DOI 10.1186/s12874-016-0144-0
   Ashton MM, 2020, CAN J PSYCHIAT, V65, P306, DOI 10.1177/0706743719889547
   Bartels SJ, 2015, AM J PSYCHIAT, V172, P344, DOI 10.1176/appi.ajp.2014.14030357
   Beriault K, 2009, INT J SPORTS MED, V30, P725, DOI 10.1055/s-0029-1231043
   Bouwmans C, 2013, BMC HEALTH SERV RES, V13, DOI 10.1186/1472-6963-13-217
   Braun V., 2006, Qual. Res. Psychol., V3, P77, DOI [10.1191/1478088706qp063oa, DOI 10.1191/1478088706QP063OA, DOI 10.1080/10875549.2021.1929659]
   Brunero S, 2009, INT J MENT HEALTH NU, V18, P144, DOI 10.1111/j.1447-0349.2009.00595.x
   Closs SJ, 2004, J PAIN SYMPTOM MANAG, V27, P196, DOI 10.1016/j.jpainsymman.2003.12.010
   Cooper SJ, 2016, J PSYCHOPHARMACOL, V30, P717, DOI 10.1177/0269881116645254
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   de Heer-Wunderink C, 2012, COMMUNITY MENT HLT J, V48, P321, DOI 10.1007/s10597-011-9381-1
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   Delespaul P H, 2013, Tijdschr Psychiatr, V55, P427
   Dimitrov BD, 2016, Arch Med Sci Atherosclerotic Dis, V1, P90
   Erlangsen A, 2017, LANCET PSYCHIAT, V4, P937, DOI 10.1016/S2215-0366(17)30429-7
   Firth J, 2019, LANCET PSYCHIAT, V6, P675, DOI 10.1016/S2215-0366(19)30132-4
   Fleuren M, 2004, INT J QUAL HEALTH C, V16, P107, DOI 10.1093/intqhc/mzh030
   Glasgow RE, 1999, AM J PUBLIC HEALTH, V89, P1322, DOI 10.2105/AJPH.89.9.1322
   Green CA, 2015, AM J PSYCHIAT, V172, P71, DOI 10.1176/appi.ajp.2014.14020173
   Gurka MJ, 2014, METABOLISM, V63, P218, DOI 10.1016/j.metabol.2013.10.006
   Happell B, 2013, J CLIN NURS, V22, P2286, DOI 10.1111/j.1365-2702.2012.04325.x
   Happell B, 2013, NURS EDUC TODAY, V33, P396, DOI 10.1016/j.nedt.2013.01.015
   Happell B, 2012, INT J MENT HEALTH NU, V21, P202, DOI 10.1111/j.1447-0349.2011.00799.x
   Haufe S, 2019, LANCET PUBLIC HEALTH, V4, pE343, DOI 10.1016/S2468-2667(19)30075-1
   Hjorthoj C, 2017, LANCET PSYCHIAT, V4, P295, DOI 10.1016/S2215-0366(17)30078-0
   Holland AE, 2014, EUR RESPIR J, V44, P1428, DOI 10.1183/09031936.00150314
   Holt RIG, 2019, BRIT J PSYCHIAT, V214, P63, DOI 10.1192/bjp.2018.167
   Howard L, 2011, J PSYCHIATR MENT HLT, V18, P105, DOI 10.1111/j.1365-2850.2010.01642.x
   Jeejeebhoy Khursheed, 2017, CMAJ Open, V5, pE229, DOI 10.9778/cmajo.20160101
   Koomen LEM., 2020, Tijdschr Psychiatr, V62, P992
   Larsson UE, 2008, PHYSIOTHER RES INT, V13, P84, DOI 10.1002/pri.398
   Law H, 2014, SCHIZOPHR RES, V156, P184, DOI 10.1016/j.schres.2014.04.011
   Nederland Z, 2020, Verbetersignalement Zorg voor mensen met psychose
   Neil ST, 2009, PSYCHOSIS, V1, P145, DOI 10.1080/17522430902913450
   Nugter MA, 2016, COMMUNITY MENT HLT J, V52, P898, DOI 10.1007/s10597-015-9831-2
   Osborn DPJ, 2010, BMC HEALTH SERV RES, V10, DOI 10.1186/1472-6963-10-61
   Pape LM, 2022, BMC PSYCHIATRY, V22, DOI 10.1186/s12888-022-03854-x
   Plana-Ripoll O, 2020, WORLD PSYCHIATRY, V19, P339, DOI 10.1002/wps.20802
   Rademakers J, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-577
   Richardson S, 2019, ADDICT BEHAV, V90, P14, DOI 10.1016/j.addbeh.2018.10.011
   Robson D, 2013, INT J MENT HEALTH NU, V22, P409, DOI 10.1111/j.1447-0349.2012.00883.x
   Siafis S, 2018, CURR NEUROPHARMACOL, V16, P1210, DOI 10.2174/1570159X15666170630163616
   Soundy A, 2014, ARCH PSYCHIAT NURS, V28, P135, DOI 10.1016/j.apnu.2013.12.002
   Stiekema APM, 2018, SCHIZOPHR RES, V199, P407, DOI 10.1016/j.schres.2018.02.053
   Teasdale SB, 2019, BRIT J PSYCHIAT, V214, P251, DOI 10.1192/bjp.2019.20
   Tuesley KM, 2019, AUST NZ J PSYCHIAT, V53, P550, DOI 10.1177/0004867418814945
   Twisk JWR, 2019, PRACT GUIDE BIOSTAT, pXI, DOI 10.1017/9781108635660
   van der Voort NTYG, 2022, J Am Psychiatr Nurs Assoc., V0
   Van Meijel B., 2020, Nurse Academy GGZ, V2, P20
   van Meijel B, 2015, PERSPECT PSYCHIATR C, V51, P106, DOI 10.1111/ppc.12071
   van Veldhuizen JR, 2007, COMMUNITY MENT HLT J, V43, P421, DOI 10.1007/s10597-007-9089-4
   Vancampfort D, 2019, WORLD PSYCHIATRY, V18, P53, DOI 10.1002/wps.20614
   Vancampfort D, 2017, WORLD PSYCHIATRY, V16, P308, DOI 10.1002/wps.20458
   Vancampfort D, 2016, GEN HOSP PSYCHIAT, V39, P15, DOI 10.1016/j.genhosppsych.2015.11.008
   Walker ER, 2015, JAMA PSYCHIAT, V72, P334, DOI 10.1001/jamapsychiatry.2014.2502
   Ware JE, 1996, MED CARE, V34, P220, DOI 10.1097/00005650-199603000-00003
   Wing JK, 1998, BRIT J PSYCHIAT, V172, P11, DOI 10.1192/bjp.172.1.11
NR 58
TC 0
Z9 0
U1 1
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD SEP 15
PY 2023
VL 23
IS 1
AR 672
DI 10.1186/s12888-023-05024-z
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA R8JS2
UT WOS:001066770200004
PM 37715156
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Crichton, GE
   Elias, MF
   Robbins, MA
AF Crichton, Georgina E.
   Elias, Merrill F.
   Robbins, Michael A.
TI Association between depressive symptoms, use of antidepressant
   medication and the metabolic syndrome: the Maine-Syracuse Study
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Depressed mood; Antidepressants; Metabolic syndrome
ID CARDIOVASCULAR-DISEASE; COGNITIVE FUNCTION; CES-D; ANXIETY; RISK;
   RELIABILITY; OBESITY; STRESS; SAMPLE; COMORBIDITY
AB Background: Both depression and the metabolic syndrome (MetS) are two major public health issues. The aim of this study was to examine associations between depressive symptoms, the use of antidepressant medications, and the prevalence of MetS.
   Methods: Cross-sectional analyses were undertaken on 970 participants from the Maine-Syracuse Study. Depressive symptoms were measured using two self-reported depression scales, the Center for Epidemiological Studies Depression Scale (CES-D), and the Zung self-rating depression scale. Antidepressant medication use was also self-reported. MetS was defined according to the recent harmonized criteria.
   Results: The risk of MetS were approximately 79 and 86 % higher for those in the highest quartile for the CES-D and the Zung (CES-D: OR = 1.79, p = 0.003; Zung: OR = 1.71, p = 0.006), compared to those in the lowest quartile. With adjustment for socio-demographic variables, lifestyle factors and C-reactive protein (CRP), risk was attenuated, but remained statistically significant for the CES-D. In those who reported using antidepressant medication, the odds of having MetS were over 2-fold higher (OR = 2.22, p < 0.001, fully adjusted model), compared to those who did not use antidepressants. Both measures of depressed mood were also associated with low high density-lipoprotein (HDL) cholesterol levels. Antidepressant use was associated with elevated fasting plasma glucose concentrations, hypertension, and low HDL-cholesterol.
   Conclusion: Depressive symptoms and the use of antidepressant medications are associated with the prevalence of MetS, and with some of the individual components of the syndrome.
C1 [Crichton, Georgina E.] Univ S Australia, Sansom Inst Hlth Res, ARENA, GPO Box 2471, Adelaide, SA 5001, Australia.
   [Elias, Merrill F.; Robbins, Michael A.] Univ Maine, Dept Psychol, Orono, ME 04469 USA.
   [Elias, Merrill F.; Robbins, Michael A.] Univ Maine, Grad Sch Biomed Sci & Engn, Orono, ME USA.
C3 University of South Australia; University of Maine System; University of
   Maine Orono; University of Maine System; University of Maine Orono
RP Crichton, GE (corresponding author), Univ S Australia, Sansom Inst Hlth Res, ARENA, GPO Box 2471, Adelaide, SA 5001, Australia.
EM georgina.crichton@unisa.edu.au
FU National Heart, Lung, and Blood Institute [R01HL67358, R01HL81290];
   National Institute on Aging [R01AG03055]; Sidney Sax Research Fellowship
   (National Health and Medical Research Council, Australia) [APP1054567]
FX The authors greatly appreciate the study participants and those who
   assisted with data collection. This study was supported in part by
   National Heart, Lung, and Blood Institute (grant numbers R01HL67358,
   R01HL81290); by the National Institute on Aging (grant R01AG03055). GEC
   was supported by a Sidney Sax Research Fellowship (National Health and
   Medical Research Council, Australia, grant number APP1054567).
CR AINSWORTH BE, 1993, MED SCI SPORT EXER, V25, P71, DOI 10.1249/00005768-199301000-00011
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Almas A, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0140742
   [Anonymous], MAJ DEPR AD
   [Anonymous], 1992, The ICD-10 classification of mental and behavioural disorders: Clinical descriptions and diagnostic guidelines
   Ärnlöv J, 2010, CIRCULATION, V121, P230, DOI 10.1161/CIRCULATIONAHA.109.887521
   Austin AW, 2014, DIABETIC MED, V31, P994, DOI 10.1111/dme.12465
   Björntorp P, 2000, BRIT J NUTR, V83, pS49, DOI 10.1017/S0007114500000957
   Blumenthal SR, 2014, JAMA PSYCHIAT, V71, P889, DOI 10.1001/jamapsychiatry.2014.414
   Butnoriene J, 2014, PSYCHONEUROENDOCRINO, V40, P269, DOI 10.1016/j.psyneuen.2013.11.002
   Cohen BE, 2015, AM J HYPERTENS, V28, P1295, DOI 10.1093/ajh/hpv047
   Corsentino EA, 2009, AM J GERIAT PSYCHIAT, V17, P155, DOI 10.1097/JGP.0b013e31818f3a6b
   Dore GA, 2008, ANN BEHAV MED, V35, P341, DOI 10.1007/s12160-008-9038-7
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   Elias MF, 2006, PSYCHOSOM MED, V68, P547, DOI 10.1097/01.psy.0000221380.92521.51
   Elias MF, 2009, HYPERTENSION, V53, P668, DOI 10.1161/HYPERTENSIONAHA.108.126342
   Fava M, 2000, J CLIN PSYCHIAT, V61, P37
   GABRYS JB, 1985, PSYCHOL REP, V57, P1091, DOI 10.2466/pr0.1985.57.3f.1091
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Goldbacher EM, 2007, ANN BEHAV MED, V34, P240, DOI 10.1007/BF02874549
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Ho JS, 2008, AM J CARDIOL, V102, P689, DOI 10.1016/j.amjcard.2008.05.010
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Kaaks R, 1997, INT J EPIDEMIOL, V26, pS15, DOI 10.1093/ije/26.suppl_1.S15
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   KNIGHT RG, 1983, BRIT J CLIN PSYCHOL, V22, P245, DOI 10.1111/j.2044-8260.1983.tb00610.x
   Knight RG, 1997, BEHAV RES THER, V35, P373, DOI 10.1016/S0005-7967(96)00107-6
   Kroke A, 1999, AM J CLIN NUTR, V70, P439
   Lin KP, 2014, BIOL RES NURS, V16, P327, DOI 10.1177/1099800413500138
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   McIntyre RS, 2012, ANN CLIN PSYCHIATRY, V24, P163
   McIntyre RS, 2010, CNS DRUGS, V24, P741, DOI 10.2165/11533280-000000000-00000
   MCKHANN G, 1984, NEUROLOGY, V34, P939, DOI 10.1212/WNL.34.7.939
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Newcomer JW, 2006, CAN J PSYCHIAT, V51, P480, DOI 10.1177/070674370605100803
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pyykkönen AJ, 2012, ANN MED, V44, P279, DOI 10.3109/07853890.2010.543921
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Rethorst CD, 2014, J CLIN PSYCHIAT, V75, pE1428, DOI 10.4088/JCP.14m09009
   Ribeiro RP, 2015, REV LAT-AM ENFERM, V23, P435
   Riboli E, 1997, INT J EPIDEMIOL, V26, pS6, DOI 10.1093/ije/26.suppl_1.S6
   Robbins MA, 2005, PSYCHOSOM MED, V67, P707, DOI 10.1097/01.psy.0000171164.50990.80
   ROBERTS RE, 1980, PSYCHIAT RES, V2, P125, DOI 10.1016/0165-1781(80)90069-4
   Rubin RR, 2008, DIABETES CARE, V31, P420, DOI 10.2337/dc07-1827
   Skalicky J, 2008, CLIN CHEM LAB MED, V46, P499, DOI 10.1515/CCLM.2008.096
   Strine TW, 2008, GEN HOSP PSYCHIAT, V30, P127, DOI 10.1016/j.genhosppsych.2007.12.008
   Wilson PWF, 2005, CIRCULATION, V112, P3066, DOI 10.1161/CIRCULATIONAHA.105.539528
   WOLF AM, 1994, INT J EPIDEMIOL, V23, P991, DOI 10.1093/ije/23.5.991
   ZUNG WWK, 1965, ARCH GEN PSYCHIAT, V12, P63, DOI 10.1001/archpsyc.1965.01720310065008
NR 50
TC 28
Z9 30
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD JUN 10
PY 2016
VL 16
AR 502
DI 10.1186/s12889-016-3170-2
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA DO3WN
UT WOS:000377713300012
PM 27287001
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Li, JB
   Wang, X
   Zhang, JX
   Gu, P
   Zhang, X
   Chen, CX
   Guo, R
   Wu, M
AF Li, J-B
   Wang, X.
   Zhang, J-X
   Gu, P.
   Zhang, X.
   Chen, C-X
   Guo, R.
   Wu, M.
TI Metabolic Syndrome: Prevalence and Risk Factors in Southern China
SO JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
LA English
DT Article
DE METABOLIC SYNDROME; PREVALENCE; RISK FACTORS; SOUTHERN CHINESE
   POPULATION
ID CORONARY-HEART-DISEASE; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   SLEEP
AB This was a cross-sectional study to investigate the epidemiology of metabolic syndrome and the distribution of interrelated metabolic abnormalities in different population groups in Guangdong, southern China. Individuals were recruited according to the percentage of different occupational populations in southern China. The study cohort included 1206 subjects, and the prevalence and distribution of the components of metabolic syndrome were assessed using the National Cholesterol Education Program Adult Treatment Panel III 2005 criteria. The unadjusted rate of metabolic syndrome was 26.7%, and the prevalences of hypertension and diabetes were 38.0% and 4.3% respectively. Hypertension, diabetes, metabolic syndrome, abdominal obesity, elevated blood glucose and elevated blood pressure decreased significantly with increasing levels of life stress and anxiety. The prevalence of hypertension and metabolic syndrome in southern China is very high, and early identification and treatment of at-risk individuals may help target intervention to improve future cardiovascular health.
C1 [Li, J-B; Wang, X.; Zhang, J-X; Zhang, X.] Sun Yat Sen Univ, Sch Publ Hlth, Dept Med Stat & Epidemiol, Guangzhou 510080, Guangdong, Peoples R China.
   [Gu, P.; Chen, C-X; Guo, R.; Wu, M.] Guangdong Acad Med Sci, Guangdong Gen Hosp, Phys Examinat Ctr, Guangzhou, Guangdong, Peoples R China.
C3 Sun Yat Sen University; Southern Medical University - China; Guangdong
   Academy of Medical Sciences & Guangdong General Hospital
RP Zhang, JX (corresponding author), Sun Yat Sen Univ, Sch Publ Hlth, Dept Med Stat & Epidemiol, 74 Zhongshan Rd 2, Guangzhou 510080, Guangdong, Peoples R China.
EM zhjinx@mail.sysu.edu.cn
RI Li, Ji-Bin/J-6381-2018; cx, chen/AGP-3922-2022
FU Guangdong Science and Technology Planned Project [2006B36008008];
   Guangdong Provincial People's Hospital
FX This study was supported by the research fund from the Guangdong Science
   and Technology Planned Project (serial number 2006B36008008). We express
   our gratitude to all the participants, physicians and nurses in
   Guangdong Provincial People's Hospital, whose support helped with the
   completion of the investigation.
CR [Anonymous], ACTA CARDIOL SIN
   Cheung BMY, 2006, BRIT J CLIN PHARMACO, V62, P260, DOI 10.1111/j.1365-2125.2006.02663.x
   Cheung BMY, 2005, J CARDIOVASC PHARM, V46, P125, DOI 10.1097/01.fjc.0000171752.43564.35
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hall MH, 2008, SLEEP, V31, P635, DOI 10.1093/sleep/31.5.635
   Kaufman D, 2007, DIABETES, V56, P1382, DOI 10.2337/db06-1409
   Klein BEK, 2002, DIABETES CARE, V25, P1790, DOI 10.2337/diacare.25.10.1790
   Kostoglou-Athanassiou I, 2008, HIPPOKRATIA, V12, P81
   李江源, 2008, [中华内分泌代谢杂志, Chinese Journal of Endocrinology and Metabolism], V24, P113
   LI JB, 2008, CHIN J PREV CONTROL, V16, P646
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Meigs JB, 2000, AM J EPIDEMIOL, V152, P908, DOI 10.1093/aje/152.10.908
   Nestel P, 2007, ASIA PAC J CLIN NUTR, V16, P362
   Neumann NU, 2009, PSYCHIAT PRAX, V36, P110, DOI 10.1055/s-2008-1067558
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Tong PCY, 2002, ARCH INTERN MED, V162, P2428, DOI 10.1001/archinte.162.21.2428
   VanItallie TB, 2002, METABOLISM, V51, P1, DOI 10.1053/meta.2002.33182
   Wang TD, 2001, AM J CARDIOL, V88, P737, DOI 10.1016/S0002-9149(01)01843-4
   Wolk R, 2007, EXP PHYSIOL, V92, P67, DOI 10.1113/expphysiol.2006.033787
NR 20
TC 32
Z9 36
U1 1
U2 10
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0300-0605
EI 1473-2300
J9 J INT MED RES
JI J. Int. Med. Res.
PD MAY-JUN
PY 2010
VL 38
IS 3
BP 1142
EP 1148
DI 10.1177/147323001003800343
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 635SY
UT WOS:000280677800044
PM 20819453
DA 2025-06-11
ER

PT J
AU Koponen, H
   Jokelainen, J
   Keinänen-Kiukaanniemi, S
   Kumpusalo, E
   Vanhala, M
AF Koponen, Hannu
   Jokelainen, Jari
   Keinanen-Kiukaanniemi, Sirkka
   Kumpusalo, Esko
   Vanhala, Mauno
TI Metabolic syndrome predisposes to depressive symptoms:: A
   population-based 7-year follow-up study
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; ASSOCIATION; OBESITY;
   DEFINITION; INVENTORY; AMERICAN; HEALTH; ADULTS
AB Objective: Previous cross-sectional studies have suggested that patients with depression have a high risk for metabolic syndrome. As there is a paucity of data concerning the temporal relationship of depression and metabolic syndrome, we decided to evaluate the risk for developing depressive symptoms in patients with metabolic syndrome in a population-based follow-up study.
   Method: The prevalence of depressive symptoms and metabolic syndrome at baseline in 1998 and at 7-year follow-up in 2004/2005 was studied in a large, middle-aged, population-based sample collected from Central Finland. Depressive symptoms were measured with the Beck Depression Inventory, with a cutoff score of 10 points. Metabolic syndrome was assessed using the modified National Cholesterol Education Program Adult Treatment Panel III criteria.
   Results: Nondepressed women and men with metabolic syndrome at baseline were twice as likely to have depressive symptoms at follow-up (OR = 2.2, 95% CI = 1.1 to 4.5 for women; OR = 2.2, 95% CI = 0.8 to 5.9 for men) as compared with the nondepressed cohort members without metabolic syndrome at baseline.
   Conclusions: The higher rate of depressive symptoms in the subgroup with metabolic syndrome suggests that the metabolic syndrome may be an important predisposing factor for the development of depression. Effective prevention and treatment of metabolic syndrome could also be important for the prevention of depression.
C1 [Koponen, Hannu] Kuopio Univ Hosp, Dept Psychiat, FIN-70211 Kuopio, Finland.
   [Koponen, Hannu] Univ Kuopio, Dept Psychiat, FIN-70211 Kuopio, Finland.
   [Kumpusalo, Esko] Univ Kuopio, Dept Family Med, Sch Publ Hlth & Clin Nutr, FIN-70211 Kuopio, Finland.
   [Kumpusalo, Esko] Kuopio Univ Hosp, Unit Family Practice, SF-70210 Kuopio, Finland.
   [Jokelainen, Jari; Keinanen-Kiukaanniemi, Sirkka] Oulu Univ, Unit Gen Practice, Dept Publ Hlth Sci, Oulu Univ Hosp, Oulu, Finland.
   [Keinanen-Kiukaanniemi, Sirkka] Oulu Hlth Ctr, Oulu, Finland.
   [Vanhala, Mauno] Cent Finland Hosp Dist, Laukaa Hlth Ctr, Jyvaskyla, Finland.
C3 Kuopio University Hospital; University of Eastern Finland; University of
   Eastern Finland; Kuopio University Hospital; University of Eastern
   Finland; University of Eastern Finland Hospital; University of Oulu;
   Central Finland Central Hospital
RP Koponen, H (corresponding author), Kuopio Univ Hosp, Dept Psychiat, POB 1777, FIN-70211 Kuopio, Finland.
EM hannujuhani.koponen@uku.fi
OI Jokelainen, Jari/0000-0003-4629-0560
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   Assmann G, 2007, AM J CARDIOL, V99, P541, DOI 10.1016/j.amjcard.2006.08.045
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   Brown ES, 2004, BIOL PSYCHIAT, V55, P1, DOI 10.1016/S0006-3223(03)00473-6
   Charo IF, 2004, CIRC RES, V95, P858, DOI 10.1161/01.RES.0000146672.10582.17
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Deisenhammer EA, 2006, ALCOHOL CLIN EXP RES, V30, P460, DOI 10.1111/j.1530-0277.2006.00050.x
   Dixon JB, 2003, ARCH INTERN MED, V163, P2058, DOI 10.1001/archinte.163.17.2058
   Dunn AJ, 2005, NEUROSCI BIOBEHAV R, V29, P891, DOI 10.1016/j.neubiorev.2005.03.023
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   Grundy SM, 2007, J CLIN ENDOCR METAB, V92, P399, DOI 10.1210/jc.2006-0513
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Heiskanen TH, 2006, J CLIN PSYCHIAT, V67, P1422, DOI 10.4088/JCP.v67n0913
   Herva A, 2006, INT J OBESITY, V30, P520, DOI 10.1038/sj.ijo.0803174
   Jasienska G, 2005, WOMEN HEALTH ISS, V15, P145, DOI 10.1016/j.whi.2005.02.002
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Maes M, 1997, ACTA PSYCHIAT SCAND, V95, P212, DOI 10.1111/j.1600-0447.1997.tb09622.x
   Pirkola SP, 2005, SOC PSYCH PSYCH EPID, V40, P1, DOI 10.1007/s00127-005-0848-7
   Plante GE, 2005, METABOLISM, V54, P45, DOI 10.1016/j.metabol.2005.01.013
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Ramasubbu R, 2002, MED HYPOTHESES, V59, P537, DOI 10.1016/S0306-9877(02)00244-X
   Roberts RE, 2003, INT J OBESITY, V27, P514, DOI 10.1038/sj.ijo.0802204
   Steer RA, 1999, J CLIN PSYCHOL, V55, P117, DOI 10.1002/(SICI)1097-4679(199901)55:1<117::AID-JCLP12>3.0.CO;2-A
   Timonen M, 2005, BMJ-BRIT MED J, V330, P17, DOI 10.1136/bmj.38313.513310.F71
   Vanhala P, 2002, J CLIN ENDOCR METAB, V87, P5834, DOI 10.1210/jc.2002-020591
NR 28
TC 139
Z9 151
U1 0
U2 9
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD FEB
PY 2008
VL 69
IS 2
BP 178
EP 182
DI 10.4088/JCP.v69n0202
PG 5
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 267JW
UT WOS:000253506300002
PM 18232723
DA 2025-06-11
ER

PT J
AU Kang, DR
   Ha, Y
   Hwang, WJ
AF Kang, Dae Ryong
   Ha, Yeongmi
   Hwang, Won Ju
TI Prevalence and Associated Risk Factor of the Metabolic Syndrome in the
   Korean Workforce
SO INDUSTRIAL HEALTH
LA English
DT Article
DE Occupational epidemiology; Work environments; Cardiovascular disorders;
   Psychosocial stress; Metabolic syndrome
ID CHOLESTEROL EDUCATION-PROGRAM; CARDIOVASCULAR-DISEASE RISK; MALE
   WORKERS; ADULTS; STRESS; DEPRESSION; OBESITY; COHORT; WOMEN
AB The purposes of this study were to estimate the prevalence of metabolic syndrome and to investigate the risk factors associated with metabolic syndrome in Korean workers. This is a secondary data analysis study using the data set from the Korean National Health and Nutrition Examination Survey IV. A total of 1,545 workers over 20 yr of age were included in this analysis. The prevalence of metabolic syndrome was determined using the modified National Cholesterol Education Program Adult Treatment Panel III criteria. Waist circumference was based on the study of obesity guidelines. The overall prevalence of metabolic syndrome among Korean workers was 21.0% (28.5% men, 11.8% women). In a multiple logistic regression analysis, male workers with high job control and heavy alcohol consumption were significantly associated with metabolic syndrome. For women, low job control and current smoking increased the risk of metabolic syndrome. The risk of developing metabolic syndrome is strongly associated with level of job control in both male and female workers. These findings suggest that behavioral lifestyle modifications, including smoking cessation, moderating alcohol consumption, and controlling work-related factors and job control in the workplace should be considered for the prevention and management of metabolic syndrome in Korean workers.
C1 [Kang, Dae Ryong] Yonsei Univ, Coll Med, Biostat Collaborat Unit, Seoul 120749, South Korea.
   [Ha, Yeongmi] Gyeongsang Natl Univ, Sch Nursing, Chinju, South Korea.
   [Ha, Yeongmi] Gyeongsang Natl Univ, Inst Hlth Sci, Chinju, South Korea.
   [Hwang, Won Ju] Kyung Hee Univ, East West Nursing Res Inst, Coll Nursing Sci, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System; Gyeongsang National
   University; Gyeongsang National University; Kyung Hee University
RP Hwang, WJ (corresponding author), Kyung Hee Univ, East West Nursing Res Inst, Coll Nursing Sci, Seoul, South Korea.
EM hwangwj@khu.ac.kr
RI Ha, Yeongmi/KXR-8828-2024
OI Hwang, Won Ju/0000-0002-0498-6183
CR Choi ES, 2009, J KOREAN ACAD NURS, V39, P549, DOI 10.4040/jkan.2009.39.4.549
   Choi KM, 2007, METABOLISM, V56, P552, DOI 10.1016/j.metabol.2006.12.003
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Demiral Y, 2006, J OCCUP HEALTH, V48, P332, DOI 10.1539/joh.48.332
   Ferrari CKB, 2008, J EXERC SCI FIT, V6, P87
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Godefroi R, 2005, CARDIOLOGY, V103, P131, DOI 10.1159/000083439
   Griffin JM, 2002, SOC SCI MED, V54, P783, DOI 10.1016/S0277-9536(01)00109-5
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hu DS, 2008, DIABETES RES CLIN PR, V81, P250, DOI 10.1016/j.diabres.2008.04.008
   Hwang WJ, 2012, J KOREAN ACAD NURS, V42, P1095, DOI 10.4040/jkan.2012.42.7.1095
   Hwang WJ, 2012, EUR J CARDIOVASC NUR, V11, P114, DOI 10.1177/1474515111430890
   Kang MG, 2005, PREV MED, V40, P583, DOI 10.1016/j.ypmed.2004.07.018
   Kim SG, 2007, J KOREAN MED SCI, V22, P968, DOI 10.3346/jkms.2007.22.6.968
   KimYangHyun, 2009, Annals of Occupational and Environmental Medicine, V21, P209
   KNSO, 2007, KOR STAND IND CLASS, V2010
   Korea Centers for Disease Control and Prevention, 2008, 4 KOR NAT HLTH NUTR
   Langenberg C, 2006, AM J PUBLIC HEALTH, V96, P2216, DOI 10.2105/AJPH.2004.049429
   Lee KJ, 2004, SEX ROLES, V51, P469, DOI 10.1023/B:SERS.0000049235.60839.ef
   Lee SY, 2007, DIABETES RES CLIN PR, V75, P72, DOI 10.1016/j.diabres.2006.04.013
   Lin YC, 2009, WORLD J GASTROENTERO, V15, P5654, DOI 10.3748/wjg.15.5654
   Lohsoonthorn Vitool, 2007, Journal of the Medical Association of Thailand, V90, P1908
   Malik Shaista, 2009, Expert Rev Cardiovasc Ther, V7, P273, DOI 10.1586/14779072.7.3.273
   Myong Jun Pyo, 2009, J Prev Med Public Health, V42, P331, DOI 10.3961/jpmph.2009.42.5.331
   Park HS, 2004, INT J EPIDEMIOL, V33, P328, DOI 10.1093/ije/dyh032
   Ryu S, 2007, ANN EPIDEMIOL, V17, P245, DOI 10.1016/j.annepidem.2006.10.001
   Schultz AB, 2009, METAB SYNDR RELAT D, V7, P459, DOI 10.1089/met.2009.0008
   Steptoe A, 2004, J HYPERTENS, V22, P915, DOI 10.1097/00004872-200405000-00012
   Weitzman ER, 2003, HEALTH PLACE, V9, P1, DOI 10.1016/S1353-8292(02)00014-X
   WHO, 2004, APPR BOD MASS IND AS, V2009
NR 30
TC 13
Z9 13
U1 0
U2 4
PU NATL INST OCCUPATIONAL SAFETY & HEALTH, JAPAN
PI KAWASAKI KANAGAWA
PA 21-1 NAGAO 6-CHOME TAMA-KU, KAWASAKI KANAGAWA, 214, JAPAN
SN 0019-8366
EI 1880-8026
J9 IND HEALTH
JI Ind. Health
PD MAY
PY 2013
VL 51
IS 3
BP 256
EP 265
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA 155YO
UT WOS:000319786800003
PM 23385434
OA Bronze
DA 2025-06-11
ER

PT J
AU Bosman, RC
   van Balkom, AJLM
   Rhebergen, D
   van Hemert, AM
   Schoevers, RA
   Penninx, BWJH
   Batelaan, NM
AF Bosman, R. C.
   van Balkom, A. J. L. M.
   Rhebergen, D.
   van Hemert, A. M.
   Schoevers, R. A.
   Penninx, B. W. J. H.
   Batelaan, N. M.
TI Predicting the course of anxiety disorders: The role of biological
   parameters
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Anxiety disorders; Course trajectory; Metabolic syndrome; HPA-axis;
   Inflammation markers; BDNF
ID COURSE TRAJECTORIES; PANIC DISORDER; SOCIAL PHOBIA; 2-YEAR COURSE;
   DEPRESSION; ASSOCIATIONS; CORTISOL; DETERMINANTS; NETHERLANDS;
   COMORBIDITY
AB Objective Clinical characteristics appear limited in their ability to predict course of anxiety disorders, therefore we explored the predictive value of biological parameters on course of anxiety disorders.
   Methods 907 persons with an anxiety (panic, social phobia, generalised anxiety) disorder with a baseline and two-year follow-up measure were selected from the Netherlands Study of Depression and Anxiety (NESDA). Previously, three course trajectories were distinguished which vary in terms of symptom severity and chronicity. Baseline clinical parameters like anxiety severity, anxiety duration, and disability were limited in their ability to predict the two-year course. This study explored whether metabolic syndrome, hypothalamic-pituitary-adrenal-axis functioning, inflammation markers, and neuroplasticity were indicators of two-year course and whether these parameters improved the model containing the most predictive clinical parameters only.
   Results Baseline diastolic blood pressure of persons with chronic moderate symptoms was significantly higher than of persons with non-chronic mild symptoms (odds ratio [OR] = 1.18, 95% confidence interval [CI95%] 1.01 to 1.38). Baseline high-density lipid cholesterol of persons with severe chronic symptoms was significantly lower than of persons with non-chronic mild symptoms (OR = 0.77, CI95% 0.62 to 0.96). The predictive ability of both parameters was however low with concordance statistics of 0.55 and 0.57 respectively. Addition of biological parameters did not improve the predictive ability of the model containing the clinical parameters.
   Conclusions In addition to clinical characteristics, biological parameters did not improve the predictive ability of the model for course trajectory of anxiety disorders. Prediction of course trajectory in anxiety disorders remains difficult and warrants further research.
C1 [Bosman, R. C.; van Balkom, A. J. L. M.; Rhebergen, D.; Penninx, B. W. J. H.; Batelaan, N. M.] Vrije Univ, Amsterdam Publ Hlth Res Inst, Amsterdam UMC, Psychiat, Amsterdam, Netherlands.
   [Bosman, R. C.; van Balkom, A. J. L. M.; Rhebergen, D.; Batelaan, N. M.] GGZ InGeest Specialized Mental Hlth Care, Amsterdam, Netherlands.
   [van Hemert, A. M.] Leiden Univ, Dept Psychiat, Med Ctr, Leiden, Netherlands.
   [Schoevers, R. A.] Univ Groningen, Univ Med Ctr Groningen, Res Sch Behav & Cognit Neurosci BCN, Dept Psychiat, Groningen, Netherlands.
C3 Vrije Universiteit Amsterdam; University of Amsterdam; Leiden
   University; Leiden University Medical Center (LUMC); Leiden University -
   Excl LUMC; University of Groningen
RP Bosman, RC (corresponding author), Vrije Univ, Amsterdam UMC, Dept Psychiat, Oldenaller 1, NL-1081 HJ Amsterdam, Netherlands.
EM r.bosman@ggzingeest.nl
RI Bosman, R.C./K-6519-2019; Penninx, Brenda WJH/S-7627-2017
OI Schoevers, Robert A/0000-0003-0760-9866; Bosman, Renske
   C./0000-0002-3143-9345; Batelaan, Neeltje/0000-0001-6444-3781; Penninx,
   Brenda WJH/0000-0001-7779-9672
FU Netherlands Organisation for Health Research and Development (ZonMw)
   [10-0001002]; VU University Medical Center; GGZ in Geest; Leiden
   University Medical Center; Leiden University; GGZ Rivierduinen;
   University Medical Center Groningen; University of Groningen; Lentis;
   GGZ Friesland; GGZ Drenthe; Rob Giel Onderzoekscentrum; VICI grant (NWO)
   [g1811602]; Neuroscience Campus Amsterdam
FX The infrastructure for the NESDA study (www.nesda.nl) is funded through
   the Geestkracht program of the Netherlands Organisation for Health
   Research and Development (ZonMw, grant number 10-0001002) and financial
   contributions by participating universities and mental health care
   organizations (VU University Medical Center, GGZ in Geest, Leiden
   University Medical Center, Leiden University, GGZ Rivierduinen,
   University Medical Center Groningen, University of Groningen, Lentis,
   GGZ Friesland, GGZ Drenthe, Rob Giel Onderzoekscentrum). BP was
   supported through a VICI grant (NWO grant g1811602). Assaying of
   inflammatory markers was supported by the Neuroscience Campus Amsterdam.
   The funding source had no involvement in the study design, in the
   collection, analysis, and interpretation of data, in the writing of the
   report, and in the decision to submit the article for publication.
CR Adam EK, 2014, PSYCHONEUROENDOCRINO, V44, P47, DOI 10.1016/j.psyneuen.2014.02.014
   Alonso J, 2004, ACTA PSYCHIAT SCAND, V109, P28
   [Anonymous], 2000, WILEY PS TX, DOI 10.1002/0471722146
   Batelaan NM, 2014, J CLIN PSYCHIAT, V75, P985, DOI 10.4088/JCP.13m08837
   Bruce SE, 2005, AM J PSYCHIAT, V162, P1179, DOI 10.1176/appi.ajp.162.6.1179
   Bus BAA, 2011, PSYCHONEUROENDOCRINO, V36, P228, DOI 10.1016/j.psyneuen.2010.07.013
   Butnoriene J, 2014, PSYCHONEUROENDOCRINO, V40, P269, DOI 10.1016/j.psyneuen.2013.11.002
   CARROLL BJ, 1981, ARCH GEN PSYCHIAT, V38, P15
   Carroll D, 2009, BIOL PSYCHIAT, V66, P91, DOI 10.1016/j.biopsych.2009.02.020
   Colman I, 2007, BIOL PSYCHIAT, V62, P1265, DOI 10.1016/j.biopsych.2007.05.012
   Eller T, 2008, PROG NEURO-PSYCHOPH, V32, P445, DOI 10.1016/j.pnpbp.2007.09.015
   Elnazer Hesham Yousry, 2014, Curr Top Behav Neurosci, V18, P191, DOI 10.1007/7854_2014_299
   Glaus J, 2018, DEPRESS ANXIETY, V35, P360, DOI 10.1002/da.22710
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hellhammer J, 2007, PSYCHONEUROENDOCRINO, V32, P80, DOI 10.1016/j.psyneuen.2006.10.005
   Hendriks SM, 2013, ACTA PSYCHIAT SCAND, V128, P212, DOI 10.1111/acps.12024
   Hovenkamp-Hermelink JHM, 2016, J AFFECT DISORDERS, V190, P310, DOI 10.1016/j.jad.2015.10.035
   Kahl KG, 2015, BRAIN BEHAV, V5, DOI 10.1002/brb3.306
   Kessler RC., 2005, Archives of General Psychiatry, V62, P12, DOI DOI 10.1001/ARCHPSYC.62.6.593
   Kruse JL, 2018, J CLIN PSYCHIAT, V79, DOI 10.4088/JCP.17m11597
   Lamers F, 2012, COMPR PSYCHIAT, V53, P63, DOI 10.1016/j.comppsych.2011.01.011
   Molendijk ML, 2012, WORLD J BIOL PSYCHIA, V13, P535, DOI 10.3109/15622975.2011.587892
   Moreira FP, 2015, PSYCHIAT GENET, V25, P201, DOI 10.1097/YPG.0000000000000097
   O'Donovan A, 2010, BRAIN BEHAV IMMUN, V24, P1074, DOI 10.1016/j.bbi.2010.03.003
   Otowa T, 2016, MOL PSYCHIATR, V21, P1391, DOI 10.1038/mp.2015.197
   Paul ED, 2013, J PSYCHOPHARMACOL, V27, P1090, DOI 10.1177/0269881113490328
   Penninx BWJH, 2008, INT J METH PSYCH RES, V17, P121, DOI 10.1002/mpr.256
   Penninx BWJH, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-129
   Ressler KJ, 2000, DEPRESS ANXIETY, V12, P2, DOI 10.1002/1520-6394(2000)12:1+<2::AID-DA2>3.3.CO;2-W
   Scholten WD, 2013, J AFFECT DISORDERS, V147, P180, DOI 10.1016/j.jad.2012.10.031
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Spinhoven P, 2016, J ANXIETY DISORD, V44, P92, DOI 10.1016/j.janxdis.2016.10.011
   Suliman S, 2013, FRONT INTEGR NEUROSC, V7, DOI 10.3389/fnint.2013.00055
   Vogelzangs N, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.27
   Vreeburg SA, 2010, PSYCHOSOM MED, V72, P340, DOI 10.1097/PSY.0b013e3181d2f0c8
   Vreeburg SA, 2009, PSYCHONEUROENDOCRINO, V34, P1109, DOI 10.1016/j.psyneuen.2009.04.024
   Wagner EYN, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0123757
   Wray NR, 2018, NAT GENET, V50, P668, DOI 10.1038/s41588-018-0090-3
   Yonkers KA, 2003, DEPRESS ANXIETY, V17, P173, DOI 10.1002/da.10106
NR 39
TC 4
Z9 4
U1 0
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD JUL 13
PY 2020
VL 101
AR 109924
DI 10.1016/j.pnpbp.2020.109924
PG 15
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA LZ0GH
UT WOS:000540909600015
PM 32179152
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Park, SJ
   Roh, S
   Hwang, J
   Kim, HA
   Kim, S
   Lee, TK
   Kang, SH
   Ha, YJ
   Jang, JW
   Park, S
AF Park, Se Jin
   Roh, Sungwon
   Hwang, Jaemin
   Kim, Hyoung Ah
   Kim, Sohye
   Lee, Tae Kyung
   Kang, Shi Hyun
   Ha, Yu Jeong
   Jang, Jung Won
   Park, Subin
TI Association between depression and metabolic syndrome in korean women:
   Results from the korean national health and nutrition examination survey
   (2007-2013)
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Metabolic syndrome; Triglyceride; Cardiovascular disease
ID CARDIOVASCULAR-DISEASE; RISK-FACTORS; MORTALITY; SYMPTOMS; CHOLESTEROL;
   MANAGEMENT; COMPONENTS; ANXIETY; EVENTS; ADULTS
AB Background: A considerable amount of research suggests that depression may be associated with cardiovascular disease (CVD) and the risk factors for the development of CVD such as metabolic syndrome (MetS). This study aimed to investigate the associations between depression, MetS, and combinations of the individual MetS components in Korean women.
   Methods: Cross-sectional data for 23,385 women who aged 19 years and older were obtained from the nationally representative Korean National Health and Nutrition Examination Survey (2007-2013). Associations between prior diagnosis of depression and MetS were estimated after adjusting for related factors using multivariable logistic regression analysis.
   Results: MetS was more prevalent in women with a prior diagnosis of depression than those without diagnosed depression (26.20% vs. 19.07%, p < .001). Depression was significantly associated with MetS (odds ratio, 1.20; 95% confidence interval, 1.01-1.43) after adjusting for age, education, monthly household income, smoking status, alcohol use, physical activity, and postmenopausal status. There was a higher prevalence of most MetS combinations among women with depression than women without depression. Specifically, significant differences between the two groups were found for MetS combinations including high triglycerides.
   Limitations: A cross-sectional study design and lack of a standardized objective measure for depression.
   Conclusions: Diagnosed depression is associated with MetS in Korean women. Specifically, women with diagnosed depression have significantly elevated levels of several combinations of MetS components including high triglycerides. Addressing these MetS combinations could help reduce CVD events and mortality among women with depression. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Park, Se Jin; Ha, Yu Jeong; Jang, Jung Won; Park, Subin] Natl Ctr Mental Hlth, Mental Hlth Res Inst, Dept Res Planning, 127 Youngmasan Ro, Seoul 04933, South Korea.
   [Roh, Sungwon] Hanyang Univ, Coll Med, Dept Psychiat, Seoul, South Korea.
   [Hwang, Jaemin] Korea Univ, Grad Sch Publ Hlth, Seoul, South Korea.
   [Kim, Hyoung Ah] Catholic Univ Korea, Dept Prevent Med, Seoul, South Korea.
   [Kim, Sohye] Seoul Natl Univ, Bundang Hosp, Hlth Promot Ctr, Songnam, South Korea.
   [Lee, Tae Kyung] Natl Ctr Mental Hlth, Dept Addict Psychiat, Seoul, South Korea.
   [Kang, Shi Hyun] Natl Ctr Mental Hlth, Dept Gen Psychiat, Seoul, South Korea.
C3 Hanyang University; Korea University; Korea University Medicine (KU
   Medicine); Catholic University of Korea; Seoul National University (SNU)
RP Park, S (corresponding author), Natl Ctr Mental Hlth, Mental Hlth Res Inst, Dept Res Planning, 127 Youngmasan Ro, Seoul 04933, South Korea.
EM subin-21@hanmail.net
RI Kim, Hanjun/AAJ-7528-2021; Kim, Hyo/AAQ-3152-2020
OI Kim, Sohye/0000-0003-0880-3580; Jang, Jungwon/0000-0002-9702-2809; Ha,
   Yujeong/0000-0002-9109-2240
FU National Center for Mental Health, Ministry of Health Welfare, Korea
   [2012-04]
FX This study was supported by an Intramural Research Grant (No. 2012-04)
   from the National Center for Mental Health, Ministry of Health &
   Welfare, Korea.
CR Ainsworth BE, 2000, MED SCI SPORT EXER, V32, pS498, DOI 10.1097/00005768-200009001-00009
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   DiMatteo MR, 2000, ARCH INTERN MED, V160, P2101, DOI 10.1001/archinte.160.14.2101
   Dortland AKBV, 2010, ACTA PSYCHIAT SCAND, V122, P30, DOI 10.1111/j.1600-0447.2010.01565.x
   Farhangi M. A., 2015, OBES RES CLIN PR, V2015
   Franco OH, 2009, CIRCULATION, V120, P1943, DOI 10.1161/CIRCULATIONAHA.109.855817
   FUCHS CS, 1995, NEW ENGL J MED, V332, P1245, DOI 10.1056/NEJM199505113321901
   Garg PR, 2013, ANN HUM BIOL, V40, P111, DOI 10.3109/03014460.2012.744094
   GLASSMAN AH, 1990, JAMA-J AM MED ASSOC, V264, P1546, DOI 10.1001/jama.264.12.1546
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hiles S. A., 2016, DEPRESS ANXIETY, V2016
   Jeffery RW, 2009, APPETITE, V52, P238, DOI 10.1016/j.appet.2008.08.008
   KEHOE R, 1994, AM J EPIDEMIOL, V139, P813, DOI 10.1093/oxfordjournals.aje.a117078
   Kim EY, 2015, J AFFECT DISORDERS, V188, P14, DOI 10.1016/j.jad.2015.08.024
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Korea Centers for Disease Control and Prevention, 2012, WEIGHT ADJ 4 KNANES
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lee CMY, 2008, DIABETES RES CLIN PR, V81, P377, DOI 10.1016/j.diabres.2008.05.011
   Lee SY, 2007, DIABETES RES CLIN PR, V75, P72, DOI 10.1016/j.diabres.2006.04.013
   Lett HS, 2004, PSYCHOSOM MED, V66, P305, DOI 10.1097/01.psy.0000126207.43307.c0
   Lim H, 2012, DIABETES CARE, V35, P2028, DOI 10.2337/dc11-1841
   Meijer A, 2011, GEN HOSP PSYCHIAT, V33, P203, DOI 10.1016/j.genhosppsych.2011.02.007
   Moreira FP, 2016, PSYCHONEUROENDOCRINO, V72, P34, DOI 10.1016/j.psyneuen.2016.06.007
   Moussavi S, 2007, LANCET, V370, P851, DOI 10.1016/S0140-6736(07)61415-9
   Muldoon MF, 2006, J CLIN ENDOCR METAB, V91, P718, DOI 10.1210/jc.2005-1654
   Oh K, 2007, EPIDEMIOL HEALTH, V29, P139
   Park JE, 2011, PSYCHIAT RES, V190, P232, DOI 10.1016/j.psychres.2011.05.040
   PENTTINEN J, 1995, AM J EPIDEMIOL, V141, P716, DOI 10.1093/oxfordjournals.aje.a117492
   Prince M, 2007, LANCET, V370, P859, DOI 10.1016/S0140-6736(07)61238-0
   Räikkönen K, 2007, DIABETES CARE, V30, P872, DOI 10.2337/dc06-1857
   Rozanski A, 2005, J AM COLL CARDIOL, V45, P637, DOI 10.1016/j.jacc.2004.12.005
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Tanomsup S, 2007, DIABETES CARE, V30, P2138, DOI 10.2337/dc07-0388
   Toker S, 2008, DEPRESS ANXIETY, V25, P661, DOI 10.1002/da.20379
   Vanhala M, 2009, ACTA PSYCHIAT SCAND, V119, P137, DOI 10.1111/j.1600-0447.2008.01283.x
   Viscogliosi G, 2013, INT J GERIATR PSYCH, V28, P242, DOI 10.1002/gps.3817
   Ziegelstein RC, 1998, ARCH INTERN MED, V158, P808, DOI 10.1001/archinte.158.7.808
NR 39
TC 29
Z9 29
U1 0
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD NOV 15
PY 2016
VL 205
BP 393
EP 399
DI 10.1016/j.jad.2016.08.022
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA DY9GC
UT WOS:000385440900051
PM 27588358
DA 2025-06-11
ER

PT J
AU Kim, AW
   Kakuhikire, B
   Baguma, C
   North, CM
   Satinsky, EN
   Perkins, JM
   Ayebare, P
   Kiconco, A
   Namara, EB
   Bangsberg, DR
   Siedner, MJ
   Tsai, AC
AF Kim, Andrew Wooyoung
   Kakuhikire, Bernard
   Baguma, Charles
   North, Crystal M.
   Satinsky, Emily N.
   Perkins, Jessica M.
   Ayebare, Patience
   Kiconco, Allen
   Namara, Elizabeth B.
   Bangsberg, David R.
   Siedner, Mark J.
   Tsai, Alexander C.
TI Adverse childhood experiences and adult cardiometabolic risk factors and
   disease outcomes: Cross-sectional, population-based study of adults in
   rural Uganda
SO JOURNAL OF GLOBAL HEALTH
LA English
DT Article
ID PRENATAL STRESS; BIRTH-WEIGHT; HEALTH; BURDEN; ASSOCIATION; DEPRESSION;
   MORTALITY; AFRICA; ABUSE; DEATH
AB Background Cardiovascular diseases (CVD) pose a major threat to public health in sub-Saharan African communities, where the burden of these classes of illnesses is expected to double by 2030. Growing research suggests that past developmental experiences and early life conditions may also elevate CVD risk throughout the life course. Greater childhood stress and adversity are consistently associated with a range of adult CVDs and associated risk factors, yet little research exists on the long-term effects of early life stress on adult physical health outcomes, especially CVD risk, in sub-Saharan African contexts. This study aims to evaluate the associations between adverse childhood experiences and adult cardiometabolic risk factors and health outcomes in a population-based study of adults living in Mbarara, a rural region of southwestern Uganda.
   Methods Data come from an ongoing, whole-population social network cohort study of adults living in the eight villages of Nyakabare Parish, Mbarara. A modified version of the Adverse Childhood Experiences-International Questionnaire (ACEs) assessed past exposure to physical, emotional, and sexual adversity. Participants also took part in a health fair where medical histories on cardiometabolic risk factors and cardiovascular diseases were gathered. Multiple logistic regression models estimated the associations between ACEs and cardiometabolic risk factors and health outcomes.
   Results Data were available on 545 adults. The average number of ACEs was 4.9 out of a possible 16. The cumulative number of ACEs were associated with having a history of heart attack and/or heart failure (adjusted odds ratio (AOR) = 1.11, 95% confidence interval (CI) = 0.999-1.234, P = 0.051), but the estimated association was not statistically significant. ACEs did not have statistically significant associations with any others measures of adult cardiometabolic risk and CVD.
   Conclusions Adverse childhood experiences are not associated with a range of adult cardiometabolic risk factors and health outcomes in this sample of rural Ugandan adults. Further research in this sample is necessary to identify the pathways that may motivate these null relationship and possibly protect against adverse cardiometabolic and cardiovascular health outcomes.
C1 [Kim, Andrew Wooyoung] Univ Witwatersrand, Fac Hlth Sci, SAMRC Wits Dev Pathways Hlth Res Unit, 29 Princess Wales Terrace, ZA-2193 Johannesburg, South Africa.
   [Kim, Andrew Wooyoung; North, Crystal M.; Satinsky, Emily N.; Siedner, Mark J.; Tsai, Alexander C.] Massachusetts Gen Hosp, Ctr Global Hlth, Boston, MA 02114 USA.
   [Kakuhikire, Bernard; Baguma, Charles; Ayebare, Patience; Kiconco, Allen; Namara, Elizabeth B.; Bangsberg, David R.; Tsai, Alexander C.] Mbarara Univ Sci & Technol, Mbarara, Uganda.
   [North, Crystal M.] Massachusetts Gen Hosp, Div Pulm & Crit Care, Boston, MA 02114 USA.
   [North, Crystal M.; Siedner, Mark J.; Tsai, Alexander C.] Massachusetts Gen Hosp, Mongan Inst, Boston, MA 02114 USA.
   [North, Crystal M.; Siedner, Mark J.; Tsai, Alexander C.] Harvard Med Sch, Boston, MA 02115 USA.
   [Perkins, Jessica M.] Vanderbilt Univ, Peabody Coll, Nashville, TN 37203 USA.
   [Bangsberg, David R.] Oregon Hlth & Sci Univ, Portland State Univ, Sch Publ Hlth, Portland, OR 97201 USA.
   [Siedner, Mark J.] Massachusetts Gen Hosp, Med Practice Evaluat Ctr, Boston, MA 02114 USA.
   [Siedner, Mark J.] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA.
C3 University of Witwatersrand; Harvard University; Harvard University
   Medical Affiliates; Massachusetts General Hospital; Mbarara University
   of Science & Technology; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Harvard University; Harvard
   University Medical Affiliates; Massachusetts General Hospital; Harvard
   University; Harvard Medical School; Vanderbilt University; Vanderbilt
   University Peabody College; Portland State University; Oregon Health &
   Science University; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Harvard University; Harvard
   University Medical Affiliates; Massachusetts General Hospital
RP Kim, AW (corresponding author), Univ Witwatersrand, Fac Hlth Sci, SAMRC Wits Dev Pathways Hlth Res Unit, 29 Princess Wales Terrace, ZA-2193 Johannesburg, South Africa.
EM awkim@mgh.harvard.edu
RI Satinsky, Emily/AAD-3114-2022; Perkins, Jessica/ABG-2467-2020; Kim,
   Andrew/JCD-9167-2023; Tsai, Alexander/F-4247-2015
OI Tsai, Alexander/0000-0001-6397-7917; Satinsky, Emily/0000-0003-0666-6009
FU Friends for a Healthy Uganda; US National Institutes of Health (NIH)
   [R01MH113494, R01MH125667]; US National Science Foundation Graduate
   Research Fellowship; Fogarty International Center; National Institute of
   Mental Health [NIH D43TW010543]
FX This work was supported by Friends for a Healthy Uganda and US National
   Institutes of Health (NIH) [R01MH113494 and R01MH125667]. AWK is
   supported by a US National Science Foundation Graduate Research
   Fellowship and the Fogarty International Center and National Institute
   of Mental Health [NIH D43TW010543]. The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the NIH.
CR Amegah AK, 2018, CIRCULATION, V138, P2449, DOI 10.1161/CIRCULATIONAHA.118.037367
   Bakema MJ, 2020, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.00069
   Basu A, 2017, CLIN PSYCHOL-SCI PR, V24, P125, DOI 10.1111/cpsp.12191
   Bellis MA, 2015, J PUBLIC HEALTH-UK, V37, P445, DOI 10.1093/pubmed/fdu065
   Brockie TN, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2018-022265
   Cluver L, 2015, J ADOLESCENT HEALTH, V57, P52, DOI 10.1016/j.jadohealth.2015.03.001
   Cohrdes C, 2020, J ADOLESCENT HEALTH, V67, P93, DOI 10.1016/j.jadohealth.2020.01.005
   Danese A, 2014, MOL PSYCHIATR, V19, P544, DOI 10.1038/mp.2013.54
   Entringer S, 2015, PSYCHONEUROENDOCRINO, V62, P366, DOI 10.1016/j.psyneuen.2015.08.019
   Felitti VJ, 1998, AM J PREV MED, V14, P245, DOI 10.1016/S0749-3797(98)00017-8
   Filmer D, 2001, DEMOGRAPHY, V38, P115, DOI 10.2307/3088292
   Flores-Torres MH, 2020, CHILD ABUSE NEGLECT, V99, DOI 10.1016/j.chiabu.2019.104175
   Godoy LC, 2021, JAMA CARDIOL, V6, P228, DOI 10.1001/jamacardio.2020.6050
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Hughes K, 2017, LANCET PUBLIC HEALTH, V2, pE356, DOI 10.1016/S2468-2667(17)30118-4
   Jewkes RK, 2010, CHILD ABUSE NEGLECT, V34, P833, DOI 10.1016/j.chiabu.2010.05.002
   Juruena MF, 2018, UNDERSTANDING DEPRES
   Kidman R, 2020, AM J PREV MED, V58, P285, DOI 10.1016/j.amepre.2019.08.028
   Kim AW, 2020, AM J PHYS ANTHROPOL, V173, P448, DOI 10.1002/ajpa.24105
   Kuzawa CW, 2012, AM J HUM BIOL, V24, P5, DOI 10.1002/ajhb.21227
   Lawal O. T., 2020, African Journal of Biomedical Research, V23, P47
   Magodoro IM, 2019, BMC CARDIOVASC DISOR, V19, DOI 10.1186/s12872-019-1072-9
   Magodoro IM, 2019, GLOB HEART, V14, P17, DOI 10.1016/j.gheart.2018.11.002
   Manyema M, 2018, BMC PUBLIC HEALTH, V18, DOI 10.1186/s12889-018-5767-0
   Monnat SM, 2015, SOCIOL QUART, V56, P723, DOI 10.1111/tsq.12107
   Mushavi RC, 2020, SOC SCI MED, V245, DOI 10.1016/j.socscimed.2019.112561
   Naicker SN, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0181522
   Nandi A, 2012, EPIDEMIOLOGY, V23, P223, DOI 10.1097/EDE.0b013e31824570bd
   North CM, 2019, J GLOB HEALTH, V9, DOI 10.7189/jogh.09.010434
   Obi IE, 2019, BRIT J PHARMACOL, V176, P1932, DOI 10.1111/bph.14576
   Oladeji BD, 2010, BRIT J PSYCHIAT, V196, P186, DOI 10.1192/bjp.bp.109.063677
   Osimo EF, 2019, PSYCHOL MED, V49, P1958, DOI 10.1017/S0033291719001454
   Pierce JB, 2020, J AM HEART ASSOC, V9, DOI 10.1161/JAHA.119.015326
   Ramiro LS, 2010, CHILD ABUSE NEGLECT, V34, P842, DOI 10.1016/j.chiabu.2010.02.012
   Roth GA, 2018, LANCET, V392, P1736, DOI 10.1016/S0140-6736(18)32203-7
   Salas J, 2019, J PSYCHOSOM RES, V127, DOI 10.1016/j.jpsychores.2019.109842
   Salawu M.M., 2020, Journal of Community Medicine and Primary Health Care, V32, P27, DOI [10.4314/jcmphc.v32i2.3, DOI 10.4314/JCMPHC.V32I2.3]
   Satinsky EN, PLOS MED
   Schmidt MR, 2020, J AGGRESS MALTREAT T, V29, P38, DOI 10.1080/10926771.2018.1524806
   Smith ML, 2020, J GLOB HEALTH, V10, DOI 10.7189/jogh.10.010412
   Su S, 2015, CURR CARDIOL REP, V17, DOI 10.1007/s11886-015-0645-1
   Takada S, 2019, SOC SCI MED, V233, P229, DOI 10.1016/j.socscimed.2019.05.012
   Tsai AC, 2012, SOC SCI MED, V74, P2012, DOI 10.1016/j.socscimed.2012.02.033
   van Ockenburg SL, 2015, ACTA PSYCHIAT SCAND, V131, P40, DOI 10.1111/acps.12286
   WADHWA PD, 1993, AM J OBSTET GYNECOL, V169, P858, DOI 10.1016/0002-9378(93)90016-C
   Yuyun MF, 2020, GLOB HEART, V15, DOI 10.5334/gh.403
NR 46
TC 5
Z9 5
U1 0
U2 6
PU INT SOC GLOBAL HEALTH
PI EDINBURGH
PA CALEDONIAN EXCHANGE, 19A CANNING ST, EDINBURGH, Lothian, ENGLAND
SN 2047-2978
EI 2047-2986
J9 J GLOB HEALTH
JI J. Glob. Health
PY 2021
VL 11
AR 04035
DI 10.7189/jogh.11.04035
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA UK7GG
UT WOS:000692133800035
PM 34386213
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Swann, SA
   King, EM
   Côté, HCF
   Murray, MCM
AF Swann, Shayda A.
   King, Elizabeth M.
   Cote, Helene C. F.
   Murray, Melanie C. M.
TI Stressing the need for validated measures of cortisol in HIV research: A
   scoping review
SO HIV MEDICINE
LA English
DT Review
DE adrenal; cortisol; HIV; review; stress
ID METABOLIC SYNDROME; WOMEN; DIAGNOSIS; INFECTION; MENOPAUSE; HORMONES;
   SYSTEMS; SALIVA; ABUSE
AB Objectives People living with HIV experience numerous endocrine abnormalities and psychosocial stressors. However, interactions between HIV, cortisol levels, and health outcomes have not been well described among people living with HIV on effective therapy. Furthermore, methods for measuring cortisol are disparate across studies. We describe the literature reporting cortisol levels in people living with HIV, describe methods to measure cortisol, and explore how this relates to health outcomes. Methods We searched the PubMed database for articles published in the past 20 years regarding HIV and cortisol with >= 50% of participants on antiretroviral therapies. Articles included observational, case-control, cross-sectional, and randomized controlled trials analyzing cortisol by any method. Studies were excluded if abnormal cortisol was due to medications or other infections. Variables were extracted from selected studies and their quality was assessed using the Newcastle-Ottawa Scale. Results In total, 19 articles were selected and included, covering the prevalence of abnormal cortisol (n = 4), exercise (n = 4), metabolic syndrome and/or cardiovascular disease (n = 2), mental health and cognition (n = 9), and sex/gender (n = 6). Cortisol was measured in serum (n = 7), saliva (n = 8), urine (n = 2), and hair (n = 3) specimens. Comparisons between people with and without HIV were inconsistent, with some evidence that people with HIV have increased rates of hypocortisolism. Depression and cognitive decline may be associated with cortisol excess, whereas anxiety and metabolic disease may be related to low cortisol; more data are needed to confirm these relationships. Conclusions Data on cortisol levels in the era of antiretroviral therapy remain sparse. Future studies should include controls without HIV, appropriately timed sample collection, and consideration of sex/gender and psychosocial factors.
C1 [Swann, Shayda A.; Cote, Helene C. F.; Murray, Melanie C. M.] Univ British Columbia, Dept Expt Med, Vancouver, BC, Canada.
   [Swann, Shayda A.; King, Elizabeth M.; Cote, Helene C. F.; Murray, Melanie C. M.] Womens Hlth Res Inst, Vancouver, BC, Canada.
   [King, Elizabeth M.; Murray, Melanie C. M.] Univ British Columbia, Dept Med, Vancouver, BC, Canada.
   [Cote, Helene C. F.] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada.
   [Cote, Helene C. F.] Univ British Columbia, Ctr Blood Res, Vancouver, BC, Canada.
   [Murray, Melanie C. M.] BC Womens Hosp & Hlth Ctr, Oak Tree Clin, Vancouver, BC, Canada.
C3 University of British Columbia; University of British Columbia;
   University of British Columbia; University of British Columbia
RP Murray, MCM (corresponding author), E600B-4500 Oak St, Vancouver, BC V6H 3N1, Canada.
EM Melanie.Murray@cw.bc.ca
RI Cote, Helene/K-7896-2012
OI Murray, Melanie/0000-0001-9538-2758; Swann, Shayda/0000-0001-7507-3747
FU Canadian Institutes of Health Research; University of British Columbia;
   Michael Smith Foundation for Health Research; Canadian HIV Trials
   Network
FX Canadian Institutes of Health Research; University of British Columbia;
   Michael Smith Foundation for Health Research; Canadian HIV Trials
   Network, Canadian Institutes of Health Research
CR Akase Iorhen E, 2018, Ghana Med J, V52, P147, DOI 10.4314/gmj.v52i3.7
   Alford K, 2018, BRIT MED BULL, V127, P55, DOI 10.1093/bmb/ldy019
   Anagnostis P, 2009, J CLIN ENDOCR METAB, V94, P2692, DOI 10.1210/jc.2009-0370
   Andany N, 2016, INT J WOMENS HEALTH, V8, P1, DOI 10.2147/IJWH.S62615
   [Anonymous], 2012, ISRN AIDS
   Arksey H., 2005, INT J SOC RES METHOD, V8, P19, DOI [DOI 10.1080/1364557032000119616, 10.1080/1364557032000119616]
   Barrett EJ., 2012, MED PHYSL, P1057
   BERGA SL, 1989, J CLIN ENDOCR METAB, V68, P301, DOI 10.1210/jcem-68-2-301
   Bremner MN, 2016, J ASSOC NURSE AIDS C, V27, P635, DOI 10.1016/j.jana.2016.04.004
   Cagnacci A, 2011, MENOPAUSE, V18, P273, DOI 10.1097/gme.0b013e3181f31947
   Condon EM, 2020, MATERN CHILD HLTH J, V24, P865, DOI 10.1007/s10995-020-02926-2
   Dale SK, 2017, AIDS CARE, V29, P598, DOI 10.1080/09540121.2016.1241378
   de Pommerol M, 2011, INT J STD AIDS, V22, P67, DOI 10.1258/ijsa.2010.010187
   Delahanty DL, 2004, AIDS CARE, V16, P247, DOI 10.1080/09540120410001641084
   Do AN, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0092842
   Donaldson MA, 2019, AIDS, V33, P2317, DOI 10.1097/QAD.0000000000002353
   Dudgeon WD, 2010, APPL PHYSIOL NUTR ME, V35, P560, DOI 10.1139/H10-045
   El-Farhan N, 2017, ANN CLIN BIOCHEM, V54, P308, DOI 10.1177/0004563216687335
   Enwonwu CO, 1996, EUR J ORAL SCI, V104, P322, DOI 10.1111/j.1600-0722.1996.tb00085.x
   Fuss J, 2019, PSYCHONEUROENDOCRINO, V104, P228, DOI 10.1016/j.psyneuen.2019.02.023
   Gaida R, 2016, EXPERT REV ANTI-INFE, V14, P377, DOI 10.1586/14787210.2016.1157469
   GLASGOW BJ, 1985, AM J CLIN PATHOL, V84, P594, DOI 10.1093/ajcp/84.5.594
   Glynn TR, 2019, INT J BEHAV MED, V26, P286, DOI 10.1007/s12529-019-09786-3
   Hamidovic A, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00311
   Hantsoo L, 2019, J BEHAV MED, V42, P1153, DOI 10.1007/s10865-019-00029-0
   Hasenmajer V, 2020, TRENDS ENDOCRIN MET, V31, P655, DOI 10.1016/j.tem.2020.04.004
   King EM, 2019, AIDS, V33, P483, DOI 10.1097/QAD.0000000000002084
   Langerak T, 2015, CLIN ENDOCRINOL, V83, P167, DOI 10.1111/cen.12790
   Laughlin GA, 2000, J CLIN ENDOCR METAB, V85, P3561, DOI 10.1210/jc.85.10.3561
   Masenga SK, 2020, CURR HYPERTENS REP, V22, DOI 10.1007/s11906-020-01089-3
   Melo BP, 2019, J PHYS ACT HEALTH, V16, P993, DOI 10.1123/jpah.2019-0134
   Mukerji SS., 2020, J INFECT DIS, DOI jiaa104
   Murnane PM, 2020, AIDS BEHAV, V24, P1632, DOI 10.1007/s10461-019-02676-5
   Nieman LK, 2008, J CLIN ENDOCR METAB, V93, P1526, DOI 10.1210/jc.2008-0125
   Nieman LK, 2018, ENDOCRINOL METAB, V33, P139, DOI 10.3803/EnM.2018.33.2.139
   Pérez-Neri I, 2008, PROG NEURO-PSYCHOPH, V32, P1118, DOI 10.1016/j.pnpbp.2007.12.001
   Pommier JD, 2019, AIDS, V33, P855, DOI 10.1097/QAD.0000000000002152
   Qiao S, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0169827
   Remien RH, 2019, AIDS, V33, P1411, DOI 10.1097/QAD.0000000000002227
   Resmini E, 2016, FRONT HORM RES, V46, P74, DOI 10.1159/000443868
   Révész D, 2014, NEUROBIOL AGING, V35, P1422, DOI 10.1016/j.neurobiolaging.2013.12.027
   Rubin LH, 2020, PSYCHONEUROENDOCRINO, V114, DOI 10.1016/j.psyneuen.2020.104609
   Rubin LH, 2018, AIDS, V32, P1983, DOI 10.1097/QAD.0000000000001930
   Rubin LH, 2017, JAIDS-J ACQ IMM DEF, V75, pE65, DOI 10.1097/QAI.0000000000001303
   Russell E, 2012, PSYCHONEUROENDOCRINO, V37, P589, DOI 10.1016/j.psyneuen.2011.09.009
   Sharma N, 2018, INDIAN J MED RES, V147, P142, DOI 10.4103/ijmr.IJMR_43_16
   Sokalski KM, 2016, CLIN ENDOCRINOL, V84, P452, DOI 10.1111/cen.12881
   Stetler C, 2011, PSYCHOSOM MED, V73, P114, DOI 10.1097/PSY.0b013e31820ad12b
   Taramasso L, 2017, OPEN FORUM INFECT DI, V4, DOI 10.1093/ofid/ofx239
   Tricco AC, 2018, ANN INTERN MED, V169, P467, DOI 10.7326/M18-0850
   Turan B, 2017, AIDS BEHAV, V21, P283, DOI 10.1007/s10461-016-1451-5
   Vingren JL, 2018, J STRENGTH COND RES, V32, P76, DOI 10.1519/JSC.0000000000002289
   Wallace I, 2009, ANN CLIN BIOCHEM, V46, P351, DOI 10.1258/acb.2009.009101
   Wells GA., 2014, The Newcastle -Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta -analyses, DOI DOI 10.1007/S10654-010-9491-Z
   Woods NF, 2009, MENOPAUSE, V16, P708, DOI 10.1097/gme.0b013e318198d6b2
   Woods NF, 2006, MENOPAUSE, V13, P212, DOI 10.1097/01.gme.0000198490.57242.2e
NR 56
TC 3
Z9 3
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1464-2662
EI 1468-1293
J9 HIV MED
JI HIV Med.
PD SEP
PY 2022
VL 23
IS 8
BP 880
EP 894
DI 10.1111/hiv.13272
EA MAR 2022
PG 15
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA 3R3NX
UT WOS:000773408000001
PM 35343039
DA 2025-06-11
ER

PT J
AU Kulak, MJ
   Lewis-de los Angeles, W
   Daniels, TE
   Mathis, KJ
   Gobin, AP
   Laumann, LE
   Beck, Q
   Tyrka, AR
AF Kulak, Meghan J.
   Lewis-de los Angeles, William
   Daniels, Teresa E.
   Mathis, Karen J.
   Gobin, Asi P.
   Laumann, Laura E.
   Beck, Quincy
   Tyrka, Audrey R.
TI Increased Cardiometabolic Risk in Healthy Young Adults With Early Life
   Stress
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE early life stress; childhood maltreatment; childhood adversity; trauma;
   metabolic syndrome; cardiometabolic risk
ID ADVERSE CHILDHOOD EXPERIENCES; FASTING PLASMA-GLUCOSE;
   CORONARY-HEART-DISEASE; METABOLIC SYNDROME; INSULIN-RESISTANCE; PHYSICAL
   ABUSE; UNITED-STATES; VALIDATION; OBESITY; TRAUMA
AB Objective: This study aimed to evaluate the relationship between early life stress (ELS) and metabolic risk in healthy young adults and assess the role of health behaviors. Methods: Young adults aged 18 to 40 years (N = 190) with no medical conditions or medication usage were recruited from the community. Participants with ELS (N = 113) had a history of childhood maltreatment, and most also experienced parental loss (n = 88). Controls (N = 77) had no history of maltreatment or parental loss. Standardized interviews and self-reports assessed demographics, adversity, medical/psychiatric history, and health behaviors. Blood pressure and anthropometrics were measured, and fasting plasma assayed for lipid profiles, glucose, insulin level, and hemoglobin A1c. We calculated both a clinical cut-point and continuous composite metabolic risk score based on clinical risk factors and the mean of z scores of each measure, respectively. Results: ELS was significantly associated with increased clinical cut-point (beta = 0.68, 95% confidence interval [CI] = 0.20-1.17, p = .006) and continuous (beta = 0.23, 95% CI = 0.08-0.038, p = .003) composite metabolic risk scores. On sensitivity analysis, the association of ELS with the continuous composite metabolic risk score was reduced to a trend after adjusting for a range of psychosocial and health predictors (beta = 0.18, 95% CI = 0.00-0.36, p = .053), with both diet and college graduate status significant in the model. Conclusions: Healthy young adults with a history of ELS have increased metabolic risk scores as compared with controls. This relationship may be partially due to health behaviors and socioeconomic factors. These findings underline that ELS is an early contributor to metabolic risk.
C1 [Kulak, Meghan J.; Daniels, Teresa E.; Mathis, Karen J.; Gobin, Asi P.; Laumann, Laura E.; Beck, Quincy; Tyrka, Audrey R.] Brown Univ, Warren Alpert Med Sch, Dept Psychiat & Human Behav, Initiat Stress Trauma & Resilience STAR, Providence, RI USA.
   [Kulak, Meghan J.; Daniels, Teresa E.; Gobin, Asi P.; Laumann, Laura E.; Beck, Quincy; Tyrka, Audrey R.] Butler Hosp, Mood Disorders Res Program, Providence, RI USA.
   [Kulak, Meghan J.; Daniels, Teresa E.; Gobin, Asi P.; Laumann, Laura E.; Beck, Quincy; Tyrka, Audrey R.] Butler Hosp, Lab Clin & Translat Neurosci, Providence, RI USA.
   [Lewis-de los Angeles, William] Hasbro Childrens Hosp, Dept Pediat, Providence, RI USA.
   [Lewis-de los Angeles, William] Bradley Hosp, Providence, RI USA.
   [Lewis-de los Angeles, William] Brown Univ, Warren Alpert Med Sch, Providence, RI USA.
   [Mathis, Karen J.] Univ Rhode Isl, Coll Nursing, Kingston, RI USA.
   [Kulak, Meghan J.] Butler Hosp, 345 Blackstone Blvd, Providence, RI 02906 USA.
C3 Brown University; Butler Hospital Rhode Island; Butler Hospital Rhode
   Island; Hasbro Children's Hospital; Brown University; University of
   Rhode Island; Butler Hospital Rhode Island
RP Kulak, MJ (corresponding author), Butler Hosp, 345 Blackstone Blvd, Providence, RI 02906 USA.
EM meghan_kulak@brown.edu; teresa_daniels@brown.edu;
   karen.mathis@brown.edu; agobin@butler.org; laura.laumann@uconn.edu;
   quincy_beck@alumni.brown.edu; audrey_tyrka@brown.edu
RI Jennings Mathis, Karen/AAK-4766-2020; Laumann, Laura/MGB-5703-2025;
   Tyrka, Audrey/L-2504-2014
OI Tyrka, Audrey/0000-0003-4653-1651; Kulak, Meghan/0000-0001-9857-6013;
   Laumann, Laura/0000-0002-1188-3991; Lewis-de los Angeles,
   William/0000-0003-3858-2299
FU National Institutes of Health [R01MH101107, P20GM139767, R21AG077332];
   National Institute of Mental Health [MH101076]; National Institute of
   Child and Human Development [T32HD101392]
FX Source of Funding and Conflicts of Interest: The authors declare no
   conflicts of interest. This work was supported by National Institutes of
   Health grants R01MH101107 (A.R.T.), and Dr. Tyrka's time was
   additionally supported by P20GM139767 and R21AG077332. Dr. Teresa
   Daniels and Dr. Meghan Kulak received support from National Institute of
   Mental Health grant MH101076 (A.R.T.), and Dr. Daniels also received
   support from the National Institute of Child and Human Development grant
   T32HD101392 (A.R.T.). Dr. William Lewis-de los Angeles and Dr. Audrey
   Tyrka also received support from the Hasbro/Bradley Pilot Clinical
   Research Award from Lifespan.
CR Agardh E, 2011, INT J EPIDEMIOL, V40, P804, DOI 10.1093/ije/dyr029
   Al-Khatib Y, 2022, CUREUS J MED SCIENCE, V14, DOI 10.7759/cureus.22153
   [Anonymous], 2017, Overview and background of the Healthy Eating Index
   Baldwin JR, 2019, JAMA PSYCHIAT, V76, P584, DOI 10.1001/jamapsychiatry.2019.0097
   BECK AT, 1988, J CONSULT CLIN PSYCH, V56, P893, DOI 10.1037/0022-006X.56.6.893
   Bernstein DP, 2003, CHILD ABUSE NEGLECT, V27, P169, DOI 10.1016/S0145-2134(02)00541-0
   Bifulco A, 1997, J CHILD PSYCHOL PSYC, V38, P365, DOI 10.1111/j.1469-7610.1997.tb01520.x
   BIFULCO A, 1994, J CHILD PSYCHOL PSYC, V35, P1419, DOI 10.1111/j.1469-7610.1994.tb01284.x
   Blair C, 2012, AM PSYCHOL, V67, P309, DOI 10.1037/a0027493
   Boynton-Jarrett R, 2012, PEDIATRICS, V130, P245, DOI 10.1542/peds.2011-1554
   Burke NJ, 2011, CHILD ABUSE NEGLECT, V35, P408, DOI 10.1016/j.chiabu.2011.02.006
   Cardel MI, 2021, ANN BEHAV MED, V55, P266, DOI 10.1093/abm/kaaa050
   Churchwell K, 2020, CIRCULATION, V142, pE454, DOI 10.1161/CIR.0000000000000936
   Danaei G, 2011, LANCET, V378, P31, DOI 10.1016/S0140-6736(11)60679-X
   Danese A, 2017, NEUROPSYCHOPHARMACOL, V42, P99, DOI 10.1038/npp.2016.198
   Danese A, 2012, PHYSIOL BEHAV, V106, P29, DOI 10.1016/j.physbeh.2011.08.019
   Danese A, 2009, ARCH PEDIAT ADOL MED, V163, P1135, DOI 10.1001/archpediatrics.2009.214
   Daniels TE, 2023, PSYCHONEUROENDOCRINO, V149, DOI 10.1016/j.psyneuen.2022.106007
   DeBoer MD, 2020, STROKE, V51, P2548, DOI 10.1161/STROKEAHA.120.028944
   DeBoer MD, 2017, J AM COLL CARDIOL, V69, P1204, DOI 10.1016/j.jacc.2016.10.088
   Deschênes SS, 2021, J AM HEART ASSOC, V10, DOI 10.1161/JAHA.120.019013
   Epel ES, 2009, HORM-INT J ENDOCRINO, V8, P7, DOI 10.14310/horm.2002.1217
   Felitti VJ, 1998, AM J PREV MED, V14, P245, DOI 10.1016/S0749-3797(98)00017-8
   Friedman EM, 2015, PSYCHOSOM MED, V77, P176, DOI 10.1097/PSY.0000000000000147
   Fuller-Rowell TE, 2019, PSYCHONEUROENDOCRINO, V107, P1, DOI 10.1016/j.psyneuen.2019.04.020
   Fuller-Thomson E, 2013, OBESITY FACTS, V6, P325, DOI 10.1159/000354609
   Gayer-Anderson C, 2020, J PSYCHIATR RES, V123, P145, DOI 10.1016/j.jpsychires.2020.02.002
   Go AS, 2014, CIRCULATION, V129, pE28, DOI 10.1161/01.cir.0000441139.02102.80
   Green JG, 2010, ARCH GEN PSYCHIAT, V67, P113, DOI 10.1001/archgenpsychiatry.2009.186
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Gunstad J, 2006, PSYCHIAT RES, V142, P31, DOI 10.1016/j.psychres.2005.11.007
   Havranek EP, 2015, CIRCULATION, V132, P873, DOI 10.1161/CIR.0000000000000228
   Hill-Briggs F, 2021, DIABETES CARE, V44, P258, DOI 10.2337/dci20-0053
   Hillier TA, 2006, DIABETOLOGIA, V49, P1528, DOI 10.1007/s00125-006-0266-8
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Hirth JM, 2011, J WOMENS HEALTH, V20, P1141, DOI 10.1089/jwh.2010.2675
   Huang H, 2015, METABOLISM, V64, P1408, DOI 10.1016/j.metabol.2015.08.019
   Hughes K, 2017, LANCET PUBLIC HEALTH, V2, pE356, DOI 10.1016/S2468-2667(17)30118-4
   Ikeda Y, 2001, ENDOCR J, V48, P81, DOI 10.1507/endocrj.48.81
   Jakubowski KP, 2018, HEALTH PSYCHOL, V37, P701, DOI 10.1037/hea0000637
   Javed Z, 2022, CIRC-CARDIOVASC QUAL, V15, P72, DOI 10.1161/CIRCOUTCOMES.121.007917
   Jimenez V, 2021, DEV PSYCHOBIOL, V63, DOI 10.1002/dev.22127
   Johnson DA, 2022, PSYCHOSOM MED, V84, P711, DOI 10.1097/PSY.0000000000001081
   Kisely S, 2023, INTERN MED J, V53, P1121, DOI 10.1111/imj.15824
   Krebs-Smith SM, 2018, J ACAD NUTR DIET, V118, P1591, DOI 10.1016/j.jand.2018.05.021
   Kuo WC, 2019, OBES REV, V20, P1651, DOI 10.1111/obr.12915
   Lee C, 2014, SOC SCI MED, V105, P122, DOI 10.1016/j.socscimed.2014.01.017
   de los Angeles WWL, 2022, ACAD PEDIATR, V22, P1281, DOI 10.1016/j.acap.2022.06.007
   Li L, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-024079
   Loucks EB, 2011, PSYCHOSOM MED, V73, P563, DOI 10.1097/PSY.0b013e318228c820
   Malinauskiene V, 2014, APPETITE, V74, P86, DOI 10.1016/j.appet.2013.12.002
   Maniam J, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00073
   Marquez FD, 2021, APPETITE, V162, DOI 10.1016/j.appet.2021.105180
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Midei AJ, 2013, HEALTH PSYCHOL, V32, P121, DOI 10.1037/a0027891
   Montez JK, 2014, DEMOGRAPHY, V51, P413, DOI 10.1007/s13524-013-0261-x
   National Cancer Institute, 2019, HEI Scoring Algorithm. HEI Scoring Algorithm
   R Studio Team, 2020, RStudio: Integrated Development for R
   Rosseel Y, 2012, J STAT SOFTW, V48, P1, DOI 10.18637/jss.v048.i02
   Ruiz R, 2018, PSYCHONEUROENDOCRINO, V96, P203, DOI 10.1016/j.psyneuen.2018.07.012
   RUSH AJ, 1986, PSYCHIAT RES, V18, P65
   Seal SV, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22073344
   Sheehan DV, 1998, J CLIN PSYCHIAT, V59, P22, DOI 10.4088/JCP.09m05305whi
   Shonkoff JP, 2016, JAMA PEDIATR, V170, P1003, DOI 10.1001/jamapediatrics.2016.1559
   Slopen N, 2014, J PEDIATR-US, V164, P631, DOI 10.1016/j.jpeds.2013.11.003
   Smith N, 2002, SOC PSYCH PSYCH EPID, V37, P572, DOI 10.1007/s00127-002-0589-9
   Thomas C, 2008, PEDIATRICS, V121, pE1240, DOI 10.1542/peds.2007-2403
   Thyfault JP, 2020, DIABETOLOGIA, V63, P1464, DOI 10.1007/s00125-020-05177-6
   Turner RJ, 2016, SOC SCI MED, V156, P114, DOI 10.1016/j.socscimed.2016.02.026
NR 70
TC 2
Z9 2
U1 1
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD FEB-MAR
PY 2024
VL 86
IS 2
BP 72
EP 82
DI 10.1097/PSY.0000000000001273
PG 11
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA HK3V1
UT WOS:001159365200009
PM 38153259
DA 2025-06-11
ER

PT J
AU Ruttle, PL
   Klein, MH
   Slattery, MJ
   Kalin, NH
   Armstrong, JM
   Essex, MJ
AF Ruttle, Paula L.
   Klein, Marjorie H.
   Slattery, Marcia J.
   Kalin, Ned H.
   Armstrong, Jeffrey M.
   Essex, Marilyn J.
TI Adolescent adrenocortical activity and adiposity: Differences by sex and
   exposure to early maternal depression
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Adiposity; Adolescence; Body mass index (BMI); Early maternal
   depression; Morning cortisol; Obesity; Reactive cortisol; Sex
   differences
ID PITUITARY-ADRENAL-AXIS; BODY-MASS INDEX; SALIVARY CORTISOL;
   MENTAL-HEALTH; ACADEMIC DIFFICULTIES; METABOLIC SYNDROME; CHILDHOOD
   OBESITY; MIDDLE CHILDHOOD; DIURNAL CORTISOL; CHRONIC STRESS
AB Prior research has linked either basal cortisol levels or stress-induced cortisol responses to adiposity; however, it remains to be determined whether these distinct cortisol measures exert joint or independent effects. Further, it is unclear how they interact with individual and environmental characteristics to predict adiposity. The present study aims to address whether morning cortisol levels and cortisol responses to a psychosocial stressor independently and/or interactively influence body mass index (BMI) in 218 adolescents (117 female) participating in a longitudinal community study, and whether associations are moderated by sex and exposure to early maternal depression. Reports of maternal depressive symptoms were obtained in infancy and preschool. Salivary cortisol measures included a longitudinal morning cortisol measure comprising sampling points across ages 11, 13, 15, and 18 and measures of stress-induced cortisol responses assessed via the Trier Social Stress Test (TSST) at age 18. Lower morning cortisol and higher TSST cortisol reactivity independently predicted higher age 18 BMI. Morning cortisol also interacted with sex and exposure to early maternal depression to predict BMI. Specifically, girls exposed to lower levels of early maternal depression displayed a strong negative morning cortisol BMI association, and girls exposed to higher levels of maternal depression demonstrated a weaker negative association. Among boys, those exposed to lower levels of maternal depression displayed no association, while those exposed to higher levels of maternal depression displayed a negative morning cortisol BMI association. Results point to the independent, additive effects of morning and reactive cortisol in the prediction of BMI and suggest that exposure to early maternal depression may exert sexually dimorphic effects on normative cortisol BMI associations. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Ruttle, Paula L.; Klein, Marjorie H.; Slattery, Marcia J.; Kalin, Ned H.; Armstrong, Jeffrey M.; Essex, Marilyn J.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Psychiat, Madison, WI 53719 USA.
C3 University of Wisconsin System; University of Wisconsin Madison
RP Ruttle, PL (corresponding author), Univ Wisconsin, Sch Med & Publ Hlth, Dept Psychiat, 6001 Res Pk Blvd, Madison, WI 53719 USA.
EM ruttle@wisc.edu
OI Kalin, Ned/0000-0003-1184-0868
FU NIH [R01-MH044340, P50-MH052354, P50-MH069315, P50-MH084051,
   R21-MH082705, UL1-RR025011]; HealthEmotions Research Institute; Robert
   Wood Johnson Foundation Health Et Society Scholars Program; University
   of Wisconsin Madison; John D. and Catherine T. MacArthur Foundation
   Research Network on Psychopathology and Development; Clinical and
   Translational Science Award (CTSA) program, through the NIH (National
   Center for Advancing Translational Sciences NCATS) [UL1TR000427];
   Canadian Institutes of Health Research Post-doctoral Fellowship
FX This research was supported by NIH grants R01-MH044340, P50-MH052354,
   P50-MH069315, P50-MH084051, R21-MH082705, and UL1-RR025011; the
   HealthEmotions Research Institute and the Robert Wood Johnson Foundation
   Health Et Society Scholars Program, both at the University of Wisconsin
   Madison; and the John D. and Catherine T. MacArthur Foundation Research
   Network on Psychopathology and Development. MJS was also supported by
   the Clinical and Translational Science Award (CTSA) program, through the
   NIH (National Center for Advancing Translational Sciences NCATS), grant
   UL1TR000427. The content is solely the responsibility of the authors and
   does not necessarily represent the official views of the NIH. Partial
   support for PLR was provided by the Canadian Institutes of Health
   Research Post-doctoral Fellowship.
CR Ashman SB, 2002, DEV PSYCHOPATHOL, V14, P333, DOI 10.1017/S0954579402002080
   Bearman SK, 2006, J YOUTH ADOLESCENCE, V35, P229, DOI 10.1007/s10964-005-9010-9
   Benson S, 2009, PSYCHONEUROENDOCRINO, V34, P181, DOI 10.1016/j.psyneuen.2008.08.019
   Björntorp P, 2000, NUTRITION, V16, P924, DOI 10.1016/S0899-9007(00)00422-6
   Bouma EMC, 2009, PSYCHONEUROENDOCRINO, V34, P884, DOI 10.1016/j.psyneuen.2009.01.003
   Boyce WT, 2002, J AM ACAD CHILD PSY, V41, P580, DOI 10.1097/00004583-200205000-00016
   Brennan PA, 2008, J CHILD PSYCHOL PSYC, V49, P1099, DOI 10.1111/j.1469-7610.2008.01914.x
   Brydon L, 2011, BIOL PSYCHOL, V86, P114, DOI 10.1016/j.biopsycho.2010.02.010
   Bryk A. S., 1992, HIERARCHICAL LINEAR
   Burghy CA, 2012, NAT NEUROSCI, V15, P1736, DOI 10.1038/nn.3257
   Burk LR, 2011, J ABNORM CHILD PSYCH, V39, P225, DOI 10.1007/s10802-010-9454-6
   Champaneri S, 2013, OBESITY, V21, pE56, DOI 10.1002/oby.20047
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   Dallman MF, 2006, PROG BRAIN RES, V153, P75, DOI 10.1016/S0079-6123(06)53004-3
   Dockray S, 2009, J ADOLESCENT HEALTH, V45, P344, DOI 10.1016/j.jadohealth.2009.06.014
   Donoho CJ, 2011, OBESITY, V19, P946, DOI 10.1038/oby.2010.287
   Dougherty LR, 2011, PSYCHOL SCI, V22, P650, DOI 10.1177/0956797611404084
   Epel ES, 2000, PSYCHOSOM MED, V62, P623, DOI 10.1097/00006842-200009000-00005
   Ertel KA, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013656
   Essex MJ, 2011, DEV PSYCHOPATHOL, V23, P1039, DOI 10.1017/S0954579411000484
   Essex MJ, 2002, J AM ACAD CHILD PSY, V41, P588, DOI 10.1097/00004583-200205000-00017
   Essex MJ, 2002, BIOL PSYCHIAT, V52, P776, DOI 10.1016/S0006-3223(02)01553-6
   Foley P, 2010, NEUROSCI BIOBEHAV R, V35, P91, DOI 10.1016/j.neubiorev.2010.01.010
   Foss B, 2011, MED HYPOTHESES, V77, P7, DOI 10.1016/j.mehy.2011.03.011
   Goodman E, 2002, PEDIATRICS, V110, P497, DOI 10.1542/peds.110.3.497
   Halliwell E., 2012, Oxford library of psychology. The Oxford handbook of the psychology of appearance, P217, DOI [10.1093/oxfordhb/9780199580521.013, DOI 10.1093/OXFORDHB/9780199580521.013, DOI 10.1093/OXFORDHB/9780199580521.013.0019]
   Hillman JB, 2012, METABOLISM, V61, P341, DOI 10.1016/j.metabol.2011.07.009
   HYDE JS, 1995, PSYCHOL WOMEN QUART, V19, P257, DOI 10.1111/j.1471-6402.1995.tb00291.x
   KIRSCHBAUM C, 1993, NEUROPSYCHOBIOLOGY, V28, P76, DOI 10.1159/000119004
   Kraak VI, 2010, J AM DIET ASSOC, V110, P192, DOI 10.1016/j.jada.2009.10.036
   Kumari M, 2010, J CLIN ENDOCR METAB, V95, P4415, DOI 10.1210/jc.2009-2105
   Lampard AM, 2014, PREV MED, V59, P60, DOI 10.1016/j.ypmed.2013.11.020
   Larsson CA, 2009, BMC ENDOCR DISORD, V9, DOI 10.1186/1472-6823-9-16
   Matchock RL, 2007, CHRONOBIOL INT, V24, P969, DOI 10.1080/07420520701649471
   MORRIS NM, 1980, J YOUTH ADOLESCENCE, V9, P271, DOI 10.1007/BF02088471
   Nieuwenhuizen AG, 2008, PHYSIOL BEHAV, V94, P169, DOI 10.1016/j.physbeh.2007.12.011
   Ogden CL, 2002, PEDIATRICS, V109, P45, DOI 10.1542/peds.109.1.45
   Pasquali R, 2012, ANN NY ACAD SCI, V1264, P20, DOI 10.1111/j.1749-6632.2012.06569.x
   PETERSEN AC, 1988, J YOUTH ADOLESCENCE, V17, P117, DOI 10.1007/BF01537962
   Phillips AC, 2012, PSYCHOSOM MED, V74, P699, DOI 10.1097/PSY.0b013e31825e3b91
   Pruessner JC, 2003, PSYCHONEUROENDOCRINO, V28, P916, DOI 10.1016/S0306-4530(02)00108-7
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Ranjit N, 2005, PSYCHONEUROENDOCRINO, V30, P615, DOI 10.1016/j.psyneuen.2005.02.003
   Ruttle P.L., 2013, DEV PSYCHOBIOL
   Ruttle PL, 2013, J ADOLESCENT HEALTH, V52, P731, DOI 10.1016/j.jadohealth.2012.11.013
   Ruttle PL, 2011, HORM BEHAV, V59, P123, DOI 10.1016/j.yhbeh.2010.10.015
   Shirtcliff EA, 2012, DEV PSYCHOBIOL, V54, P493, DOI 10.1002/dev.20607
   Spencer SJ, 2011, STRESS, V14, P233, DOI 10.3109/10253890.2010.534831
   Stulnig TM, 2004, DIABETOLOGIA, V47, P1, DOI 10.1007/s00125-003-1284-4
   Wajchenberg BL, 2000, ENDOCR REV, V21, P697, DOI 10.1210/er.21.6.697
   Walker BR, 2000, J INTERN MED, V247, P198, DOI 10.1046/j.1365-2796.2000.00609.x
   Wallerius S, 2003, J ENDOCRINOL INVEST, V26, P616, DOI 10.1007/BF03347017
NR 52
TC 16
Z9 20
U1 0
U2 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD SEP
PY 2014
VL 47
BP 68
EP 77
DI 10.1016/j.psyneuen.2014.04.025
PG 10
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA AM2PY
UT WOS:000339694500008
PM 25001956
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Vaghef-Mehrabani, E
   Izadi, A
   Ebrahimi-Mameghani, M
AF Vaghef-Mehrabani, Elnaz
   Izadi, Azimeh
   Ebrahimi-Mameghani, Mehrangiz
TI The association of depression with metabolic syndrome parameters and
   malondialdehyde (MDA) in obese women: A case-control study
SO HEALTH PROMOTION PERSPECTIVES
LA English
DT Article
DE Insulin resistance; Major; depressive disorder; Malondialdehyde;
   Metabolic; syndrome; Obesity; Oxidative; stress
ID TERM ANTIDEPRESSANT TREATMENT; OXIDATIVE STRESS; 1ST EPISODE; DISORDER;
   HEALTH; RISK; SYMPTOMS; ANXIETY; SAMPLES
AB Background: There is evidence for a bidirectional association between obesity and depression, and obesity is the main risk factor for metabolic syndrome (MetS). This study aimed to compare oxidative stress and MetS features between depressed and non-depressed obese women and study the association of depressive symptoms, oxidative stress, and components of MetS.
   Methods: In this case-control study conducted in Tabriz (East Azarbaijan, Iran), obese women (body mass index [BMI]: 30-40 kg/m(2)) with a primary diagnosis of major depressive disorder (MDD; based on diagnostic interview with a psychiatrist; n = 75) and their age-matched nondepressed controls (n = 150) were enrolled. Beck Depression Inventory-version II (BDI-II) was used to assess depressive symptoms in both groups. Anthropometric parameters, blood pressure, fasting blood sugar (FBS), lipid profile and malondialdehyde (MDA) were measured.
   Results: No significant differences in anthropometric parameters and blood pressure were observed between the two groups. However, FBS of the MDD group was significantly higher than the control (P < 0.05). FBS was significantly correlated with BDI-II scores (r = 0.158, P = 0.017). No significant difference in lipid profile was observed between the groups. Serum MDA level was significantly lower in the MDD group and was inversely associated with BDI-II scores (r=-0.328, P < 0.001). Overall, MDD was not significantly associated with MetS in our study (OR = 0.848, 95% CI: 0.484, 1.487; P= 0.566).
   Conclusion: Although we found a correlation between higher depressive symptoms and some adverse metabolic outcomes, our findings do not support a significant association between MDD and MetS.
C1 [Vaghef-Mehrabani, Elnaz] Univ Calgary, Cumming Sch Med, Dept Pediat, Calgary, AB, Canada.
   [Izadi, Azimeh] Tabriz Univ Med Sci, Sch Nutr & Food Sci, Dept Biochem & Diet Therapy, Tabriz, Iran.
   [Ebrahimi-Mameghani, Mehrangiz] Tabriz Univ Med Sci, Nutr Res Ctr, Sch Nutr & Food Sci, Dept Biochem & Diet Therapy, Tabriz, Iran.
C3 University of Calgary; Tabriz University of Medical Science; Tabriz
   University of Medical Science
RP Ebrahimi-Mameghani, M (corresponding author), Tabriz Univ Med Sci, Nutr Res Ctr, Sch Nutr & Food Sci, Dept Biochem & Diet Therapy, Tabriz, Iran.
EM ebrahimimamagani@tbzmed.ac.ir
RI Izadi, Azimeh/K-6025-2018; Ebrahimi-Mameghani, Mehrangiz/G-6461-2017
OI Vaghef Mehrabani, Elnaz/0000-0003-0890-2618; Ebrahimi-Mameghani,
   Mehrangiz/0000-0002-0311-1289
FU "Nutrition Research Center" of Tabriz University of Medical Sciences,
   Tabriz, Iran
FX This work was funded by the "Research Vice-Chancellor" and "Nutrition
   Research Center" of Tabriz University of Medical Sciences, Tabriz, Iran.
CR Amini S, 2019, INT J PREVENTIVE MED, V10, DOI 10.4103/ijpvm.IJPVM_372_17
   Barbosa M.L., 2020, Neurology Psychiatry and Brain Research, DOI [DOI 10.1016/J.NPBR.2020.02.006, 10.1016/j.npbr.2020.02.006]
   Block A, 2016, NORD J PSYCHIAT, V70, P611, DOI 10.1080/08039488.2016.1191535
   Camkurt MA, 2016, PSYCHIAT RES, V238, P81, DOI 10.1016/j.psychres.2016.01.075
   Cheng H.L., 2016, SIMPLE EASY TO USE S
   Delavari A, 2009, DIABETES CARE, V32, P1092, DOI 10.2337/dc08-1800
   Demirci H, 2011, KLIN PSIKOFARMAKOL B, V21, P49
   Dodd S, 2008, INT J NEUROPSYCHOPH, V11, P179
   Faith MS, 2011, OBES REV, V12, pe438, DOI 10.1111/j.1467-789X.2010.00843.x
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Galecki P, 2009, PHARMACOL REP, V61, P436
   Ghassemzadeh H, 2005, DEPRESS ANXIETY, V21, P185, DOI 10.1002/da.20070
   Gurka MJ, 2016, PSYCHONEUROENDOCRINO, V68, P82, DOI 10.1016/j.psyneuen.2016.02.030
   Han Changwoo, 2016, J Prev Med Public Health, V49, P260
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Hildrum B, 2009, ACTA PSYCHIAT SCAND, V120, P14, DOI 10.1111/j.1600-0447.2008.01315.x
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Kotan VO, 2011, PROG NEURO-PSYCHOPH, V35, P1284, DOI 10.1016/j.pnpbp.2011.03.021
   Kucerova J, 2015, BIOMED PAP, V159, P208, DOI 10.5507/bp.2014.060
   Lamers F, 2018, PSYCHOL MED, V48, P1102, DOI 10.1017/S0033291717002483
   Liu JH, 2020, DIABETOL METAB SYNDR, V12, DOI 10.1186/s13098-020-00526-2
   Liu ZH, 2017, J AFFECT DISORDERS, V220, P95, DOI 10.1016/j.jad.2017.05.023
   Majdzadeh R., 2018, J NUTR FASTING HLTH, V6, P139, DOI [10.22038/ jnfh.2018.34334.1139, DOI 10.22038/JNFH.2018.34334.1139]
   Miettola J, 2008, SCAND J PRIM HEALTH, V26, P203, DOI 10.1080/02813430802117624
   Pan A, 2012, DIABETOLOGIA, V55, P63, DOI 10.1007/s00125-011-2268-4
   Ploughman M, 2020, MULT SCLER RELAT DIS, V40, DOI 10.1016/j.msard.2019.101919
   Puustinen PJ, 2011, PSYCHOSOM MED, V73, P158, DOI 10.1097/PSY.0b013e3182037315
   Rigobon Alanna V, 2018, BMC Obes, V5, P32, DOI 10.1186/s40608-018-0208-2
   Rybka J, 2013, FREE RADICAL BIO MED, V63, P187, DOI 10.1016/j.freeradbiomed.2013.05.019
   Sadeghirad B, 2010, INT J PREVENTIVE MED, V1, P81
   Salk RH, 2017, PSYCHOL BULL, V143, P783, DOI 10.1037/bul0000102
   Sarandol A, 2007, HUM PSYCHOPHARM CLIN, V22, P67, DOI 10.1002/hup.829
   Schmitz N, 2016, MOL PSYCHIATR, V21, P1726, DOI 10.1038/mp.2016.7
   Schmitz N, 2014, DIABETES CARE, V37, P970, DOI 10.2337/dc13-1832
   Sekita A, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-862
   Shelton RC, 2015, J PSYCHIATR RES, V70, P91, DOI 10.1016/j.jpsychires.2015.09.001
   Staiano AE, 2016, OBESITY, V24, P1969, DOI 10.1002/oby.21567
   Stefanescu C, 2012, J AFFECT DISORDERS, V143, P34, DOI 10.1016/j.jad.2012.05.022
   Takeuchi T, 2009, DIABETES METAB, V35, P32, DOI 10.1016/j.diabet.2008.06.006
   Vittengl JR, 2018, PSYCHIAT RES, V264, P254, DOI 10.1016/j.psychres.2018.03.023
NR 40
TC 3
Z9 3
U1 1
U2 2
PU TABRIZ UNIV MEDICAL SCIENCES & HEALTH SERVICES
PI TABRIZ
PA DANESHGHAH ST, TABRIZ, REPUBLIC ISLAMIC 51664-14766, IRAN
SN 2228-6497
J9 HEALTH PROMOT PERSPE
JI Health Promot. Perspect.
PY 2021
VL 11
IS 4
BP 492
EP 497
DI 10.34172/hpp.2021.62
PG 6
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA XU3TO
UT WOS:000734191900016
PM 35079595
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Correia-Costa, L
   Sousa, T
   Morato, M
   Cosme, D
   Afonso, J
   Areias, JC
   Schaefer, F
   Guerra, A
   Afonso, AC
   Azevedo, A
   Albino-Teixeira, A
AF Correia-Costa, Liane
   Sousa, Teresa
   Morato, Manuela
   Cosme, Dina
   Afonso, Joana
   Areias, Jose C.
   Schaefer, Franz
   Guerra, Antonio
   Afonso, Alberto C.
   Azevedo, Ana
   Albino-Teixeira, Antonio
TI Oxidative stress and nitric oxide are increased in obese children and
   correlate with cardiometabolic risk and renal function
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Paediatric obesity; Oxidative stress; Nitric oxide; Risk factors;
   Glomerular filtration rate
ID DIET-INDUCED OBESITY; INSULIN-RESISTANCE; CARDIOVASCULAR RISK; METABOLIC
   SYNDROME; LIFE-STYLE; HYPERTENSION; ADOLESCENTS; CHILDHOOD; MARKERS;
   DISEASE
AB Oxidative stress and nitric oxide (NO) appear to represent important links between obesity and cardiovascular, metabolic and/or renal disease. We investigated whether oxidative stress and NO production/metabolism are increased in overweight and obese prepubertal children and correlate with cardiometabolic risk and renal function. We performed a cross-sectional evaluation of 313 children aged 8-9 years. Anthropometrics, 24-h ambulatory blood pressure, pulse wave velocity (PWV), insulin resistance (homoeostasis model assessment index (HOMA-IR)), inflammatory/metabolic biomarkers, estimated glomerular filtration rate (eGFR), plasma total antioxidant status (TAS), plasma and urinary isoprostanes (P-Isop, U-Isop), urinary hydrogen peroxide (U-H2O2), and plasma and urinary nitrates and nitrites (P-NOx, U-NOx) were compared among normal weight, overweight and obese groups, according to WHO BMI z-score reference. U-Isop were increased in the obese group, whereas U-NOx were increased in both overweight and obese children. U-Isop were positively correlated with U-H2O2, myeloperoxidase (MPO), high-sensitivity C-reactive protein, HOMA-IR and TAG. TAS correlated negatively with U-Isop and MPO and positively with PWV. HOMA-IR and U-H2O2 were associated with higher U-Isop, independently of BMI and eGFR, and total cholesterol and U-H2O2 were associated with U-NOx, independently of BMI, eGFR values and P-NOx concentration. In overweight and obese children, eGFR decreased across P-NOx tertiles (median: 1393 (25th, 75th percentile 1280, 1465), 1280 (25th, 75th percentile 1215, 1404), 1295 (25th, 75th percentile 1194, 1383), P-for linear trend=0003). We conclude that oxidant status and NO are increased in relation to fat accumulation and, even in young children, they translate into higher values of cardiometabolic risk markers and affect renal function.
C1 [Correia-Costa, Liane; Cosme, Dina; Afonso, Alberto C.; Azevedo, Ana] Univ Porto, EPIUnit, Inst Publ Hlth, Rua Taipas 135, P-4050600 Oporto, Portugal.
   [Correia-Costa, Liane; Afonso, Alberto C.] Integrated Pediat Hosp, Div Pediat Nephrol, Ctr Hos Sao Joao, Alameda Prof Hernani Monteiro, P-4200319 Oporto, Portugal.
   [Correia-Costa, Liane; Areias, Jose C.; Guerra, Antonio; Afonso, Alberto C.] Univ Porto, Dept Pediat, Fac Med, Alameda Prof Hernani Monteiro, P-4200319 Oporto, Portugal.
   [Sousa, Teresa; Morato, Manuela; Cosme, Dina; Afonso, Joana; Albino-Teixeira, Antonio] Univ Porto, Dept Pharmacol & Therapeut, Fac Med, Rua Dr Placido da Costa 91, P-4200450 Oporto, Portugal.
   [Sousa, Teresa; Morato, Manuela; Afonso, Joana; Albino-Teixeira, Antonio] Univ Porto, MedInUP Ctr Drug Discovery & Innovat Med, Alameda Prof Hernani Monteiro, P-4200319 Oporto, Portugal.
   [Morato, Manuela] Univ Porto, Fac Pharm Porto, Dept Drug Sci, Pharmacol Lab, Rua Jorge Viterbo Ferreira 228, P-4050313 Oporto, Portugal.
   [Areias, Jose C.] Integrated Pediat Hosp, Div Pediat Cardiol, Ctr Hospitalar Sao Joao, Alameda Prof Hernani Monteiro, P-4200319 Oporto, Portugal.
   [Schaefer, Franz] Heidelberg Univ, Div Pediat Nephrol, Ctr Pediat & Adolescent Med, Neuenheimer Feld 430, D-69120 Heidelberg, Germany.
   [Guerra, Antonio] Integrated Pediat Hosp, Div Pediat Nutr, Ctr Hosp Sao Joao, Alameda Prof Hernani Monteiro, P-4200319 Oporto, Portugal.
   [Azevedo, Ana] Univ Porto, Fac Med, Dept Clin Epidemiol Predict Med & Publ Hlth, Alameda Prof Hernani Monteiro, P-4200319 Oporto, Portugal.
C3 Universidade do Porto; Universidade do Porto; Universidade do Porto;
   Universidade do Porto; Universidade do Porto; Sao Joao Hospital;
   Ruprecht Karls University Heidelberg; Sao Joao Hospital; Universidade do
   Porto
RP Sousa, T (corresponding author), Univ Porto, Dept Pharmacol & Therapeut, Fac Med, Rua Dr Placido da Costa 91, P-4200450 Oporto, Portugal.; Sousa, T (corresponding author), Univ Porto, MedInUP Ctr Drug Discovery & Innovat Med, Alameda Prof Hernani Monteiro, P-4200319 Oporto, Portugal.
EM tsousa@med.up.pt
RI Morato, Manuela/D-7563-2013; Correia-Costa, Liane/JPA-4135-2023; ,
   Teresa/HSF-0698-2023; Afonso, Carlos/M-7833-2013; Azevedo,
   Ana/AAA-2287-2020; Afonso, Joana/A-4395-2016; Albino-Teixeira,
   Antonio/HPI-0713-2023
OI Albino-Teixeira, Antonio/0000-0003-0097-2953; Schaefer,
   Franz/0000-0001-7564-9937; Azevedo, Ana/0000-0002-7368-9609; Cosme,
   Dina/0000-0002-8398-0184; Morato, Manuela/0000-0002-9509-0613; Caldas
   Afonso, Alberto/0000-0002-2574-4132; Sousa, Teresa/0000-0001-7230-5020;
   Correia-Costa, Liane/0000-0002-8216-090X; Areias, Jose
   Carlos/0000-0002-9833-2518
FU Fundo Europeu de Desenvolvimento Regional (FEDER) funds from Programa
   Operacional Factores de Competitividade - COMPETE
   [FCOMP-01-0124-FEDER-028751]; Portuguese Foundation for Science and
   Technology (FCT), Lisbon, Portugal [PTDC/DTP-PIC/0239/2012]; Calouste
   Gulbenkian Foundation; FCT [SFRH/SINTD/95898/2013]; Programa Operacional
   Potencial Humano (POPH)/Fundo Social Europeu (FSE) (EC)
   [SFRH/BPD/112005]; European Renal Association - European Dialysis and
   Transplant Association Research Programme, Parma, Italy; KfH Foundation
   for Preventive Medicine, Neu-Isenburg, Germany; COMPETE; POPH/FSE (EC);
   European Renal Association; KfH Foundation for Preventive Medicine;
   Fundação para a Ciência e a Tecnologia [SFRH/SINTD/95898/2013,
   PTDC/DTP-PIC/0239/2012] Funding Source: FCT
FX This project was supported by the Fundo Europeu de Desenvolvimento
   Regional (FEDER) funds from Programa Operacional Factores de
   Competitividade - COMPETE (FCOMP-01-0124-FEDER-028751), by national
   funds from the Portuguese Foundation for Science and Technology (FCT),
   Lisbon, Portugal (PTDC/DTP-PIC/0239/2012), and by Calouste Gulbenkian
   Foundation. L. C.- C. was supported by FCT (grant
   SFRH/SINTD/95898/2013), T. S. was supported by FCT and Programa
   Operacional Potencial Humano (POPH)/Fundo Social Europeu (FSE) (EC)
   (Ciencia 2008 and SFRH/BPD/112005) and F. S. was supported by the
   European Renal Association - European Dialysis and Transplant
   Association Research Programme, Parma, Italy, and the KfH Foundation for
   Preventive Medicine, Neu-Isenburg, Germany. The funders COMPETE, FCT,
   Calouste Gulbenkian Foundation, POPH/FSE (EC), European Renal
   Association and KfH Foundation for Preventive Medicine had no role in
   the design, analysis or writing of this article.
CR [Anonymous], VASCUL PHARM
   Attia DM, 2002, KIDNEY INT, V61, P1776, DOI 10.1046/j.1523-1755.2002.00313.x
   Beltowski J, 2012, CLIN EXP PHARMACOL P, V39, P168, DOI 10.1111/j.1440-1681.2011.05623.x
   Bravo PE, 2006, VASC HEALTH RISK MAN, V2, P163, DOI 10.2147/vhrm.2006.2.2.163
   Chen B, 2015, J ENDOCRINOL, V225, pR83, DOI 10.1530/JOE-14-0662
   Codoñer-Franch P, 2014, CLIN BIOCHEM, V47, P44, DOI 10.1016/j.clinbiochem.2013.10.021
   Codoñer-Franch P, 2012, PEDIATR DIABETES, V13, P369, DOI 10.1111/j.1399-5448.2011.00847.x
   Codoñer-Franch P, 2011, TRANSL RES, V158, P369, DOI 10.1016/j.trsl.2011.08.004
   Codoñer-Franch P, 2011, ATHEROSCLEROSIS, V215, P475, DOI 10.1016/j.atherosclerosis.2010.12.035
   Correia-Costa L, 2015, PEDIATR RES, V78, P436, DOI 10.1038/pr.2015.130
   de Onis M, 2007, B WORLD HEALTH ORGAN, V85, P660, DOI 10.2471/BLT.07.043497
   Dennis BA, 2013, CHILD OBES, V9, P15, DOI 10.1089/chi.2011.0092
   Diaz KM, 2011, INT J HYPERTENS, V2010, P13706
   Dobrian AD, 2004, HYPERTENSION, V43, P48, DOI 10.1161/01.HYP.0000103629.01745.59
   Durao C, 2015, EUR J NUTR, V54, P835, DOI 10.1007/s00394-014-0762-4
   Duzova A, 2013, NEPHROL DIAL TRANSPL, V28, P166, DOI 10.1093/ndt/gft317
   Eren E, 2014, J CLIN RES PEDIATR E, V6, P163, DOI [10.4274/jcrpe.1454, 10.4274/Jcrpe.1454]
   Faienza MF, 2012, HORM RES PAEDIAT, V78, P158, DOI 10.1159/000342642
   Flynn JT, 2014, HYPERTENSION, V63, P1116, DOI 10.1161/HYP.0000000000000007
   Fok H, 2012, HYPERTENSION, V60, P1220, DOI 10.1161/HYPERTENSIONAHA.112.198788
   Gabbai FB, 2001, NEPHROL DIAL TRANSPL, V16, P10, DOI 10.1093/ndt/16.suppl_1.10
   Ghantous CM, 2015, INT J ENDOCRINOL, V2015, DOI 10.1155/2015/534320
   Giannini C, 2008, ATHEROSCLEROSIS, V197, P448, DOI 10.1016/j.atherosclerosis.2007.06.023
   Goonasekera CDA, 1997, ARCH DIS CHILD, V77, P11, DOI 10.1136/adc.77.1.11
   Gruber HJ, 2008, INT J OBESITY, V32, P826, DOI 10.1038/sj.ijo.0803795
   Kelishadi R, 2008, CLIN CHEM, V54, P147, DOI 10.1373/clinchem.2007.089953
   Kopkan L, 2009, AM J PHYSIOL-RENAL, V297, pF1606, DOI 10.1152/ajprenal.90743.2008
   Larsen PS, 2013, PAEDIATR PERINAT EP, V27, P393, DOI 10.1111/ppe.12060
   Liu W, 2009, FREE RADICAL BIO MED, V47, P1101, DOI 10.1016/j.freeradbiomed.2009.07.028
   Loffredo L, 2012, J PEDIATR-US, V161, P1004, DOI 10.1016/j.jpeds.2012.05.042
   Justo ML, 2013, J NUTR BIOCHEM, V24, P1453, DOI 10.1016/j.jnutbio.2012.12.004
   Marczak ED, 2012, PHARMACOGENET GENOM, V22, P620, DOI 10.1097/FPC.0b013e32835516e5
   McIntosh N, 2000, Arch Dis Child, V82, P177
   McNeilly AM, 2012, J SPORT SCI, V30, P725, DOI 10.1080/02640414.2012.671952
   Meyer AA, 2006, PEDIATRICS, V117, P1560, DOI 10.1542/peds.2005-2140
   Milne GL, 2015, BBA-MOL CELL BIOL L, V1851, P433, DOI 10.1016/j.bbalip.2014.10.007
   Molnár D, 2004, INT J OBESITY, V28, P1197, DOI 10.1038/sj.ijo.0802719
   Natl High Blood Pressure Educ Prog, 2004, PEDIATRICS, V114, P555
   Ostrow V, 2011, J PEDIATR-US, V158, P628, DOI 10.1016/j.jpeds.2010.09.081
   Pacher P, 2007, PHYSIOL REV, V87, P315, DOI 10.1152/physrev.00029.2006
   Prabhakar S, 2007, J AM SOC NEPHROL, V18, P2945, DOI 10.1681/ASN.2006080895
   Redon J, 2015, CURR HYPERTENS REP, V17, DOI 10.1007/s11906-015-0555-z
   Remer T, 2002, AM J CLIN NUTR, V75, P561, DOI 10.1093/ajcn/75.3.561
   Sakuragi S, 2009, HYPERTENSION, V53, P611, DOI 10.1161/HYPERTENSIONAHA.108.123364
   Sansbury BE, 2012, CIRC RES, V111, P1176, DOI [10.1161/CIRCRESAHA.112.266395, 10.1161/circresaha.112.266395]
   Savino A, 2006, DIABETES CARE, V29, P2676, DOI 10.2337/dc06-0346
   Savino A, 2011, PEDIATR NEPHROL, V26, P749, DOI 10.1007/s00467-010-1659-y
   Savino A, 2010, HORM RES PAEDIAT, V73, P303, DOI 10.1159/000308161
   Sousa T, 2012, BRIT J PHARMACOL, V166, P2386, DOI 10.1111/j.1476-5381.2012.01957.x
   Sousa T, 2012, LIPID PEROXIDATION, P345, DOI 10.5772/50346
   Stringer DM, 2009, PEDIATR DIABETES, V10, P269, DOI 10.1111/j.1399-5448.2008.00473.x
   Tsuchiya K, 2007, ENDOCRINOLOGY, V148, P4548, DOI 10.1210/en.2006-1371
   Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
   Warolin J, 2014, PEDIATR OBES, V9, P43, DOI 10.1111/j.2047-6310.2012.00135.x
   Zappitelli M, 2006, AM J KIDNEY DIS, V48, P221, DOI 10.1053/j.ajkd.2006.04.085
NR 55
TC 33
Z9 35
U1 0
U2 15
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD SEP 14
PY 2016
VL 116
IS 5
BP 805
EP 815
DI 10.1017/S0007114516002804
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DV4KM
UT WOS:000382894500005
PM 27480380
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Doom, JR
   Deer, LK
   Mickel, T
   Infante, A
   Rivera, KM
AF Doom, Jenalee R.
   Deer, LillyBelle K.
   Mickel, Trudy
   Infante, Andrea
   Rivera, Kenia M.
TI Eating Behaviors as Pathways From Early Childhood Adversity to
   Adolescent Cardiometabolic Risk
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE Avon Longitudinal Study of Parents and Children; childhood adversity;
   adolescence; eating behavior; cardiometabolic risk
ID EMOTION DYSREGULATION; SCIENTIFIC STATEMENT; MATERNAL DEPRESSION;
   LIFE-SPAN; STRESS; CHILDREN; SYMPTOMS; INDEXES; TRAUMA; HEALTH
AB Objective: To identify specific eating behavior pathways that mediate associations between financial difficulties, negative life events, and maternal depressive symptoms from 0 to 5 years and cardiometabolic risk in adolescence. Method: Hypotheses were tested with data from birth to age 15 years using the Avon Longitudinal Study of Parents and Children, a birth cohort in the United Kingdom (n = 3,887 for current analyses). Mothers reported on financial difficulties, negative life events, and maternal depressive symptoms at multiple points from 0 to 5 years and reported on worry about child overeating at 8 years. Youth self-reported restrained, emotional, and external eating at age 14. Youth completed a cardiometabolic health assessment at age 15 where waist circumference, triglycerides, high-density lipoprotein, and insulin resistance were measured. Longitudinal structural equation modeling with bootstrapping was used to test mediation models. Results: Greater negative life events and maternal depressive symptoms predicted greater parental worry about child overeating at age 8, which directly predicted greater restrained and emotional eating at 14 and cardiometabolic risk at 15. Restrained and emotional eating at 14 directly predicted greater cardiometabolic risk at age 15. Conclusions: Negative life events and maternal depressive symptoms in infancy/early childhood are associated with cardiometabolic risk in adolescence through pathways of parental worry about child overeating in middle childhood and youth-reported restrained and emotional eating in adolescence.
C1 [Doom, Jenalee R.; Deer, LillyBelle K.; Mickel, Trudy; Infante, Andrea; Rivera, Kenia M.] Univ Denver, Dept Psychol, Denver, CO 80210 USA.
C3 University of Denver
RP Doom, JR (corresponding author), Univ Denver, Dept Psychol, Denver, CO 80210 USA.
EM jena.doom@du.edu
RI Deer, LillyBelle/W-9369-2019
OI Doom, Jenalee/0000-0003-2857-0817
FU U.K. Medical Research Council; Wellcome [217065/Z/19/Z]; University of
   Bristol; National Heart, Lung, And Blood Institute [K01HL143159,
   F32HL165844]
FX The U.K. Medical Research Council and Wellcome (Grant 217065/Z/19/Z)and
   the University of Bristol provide core support for Avon Longitudinal
   Study of Parents and Children (ALSPAC). A comprehensive list of grants
   funding is available on the ALSPAC website
   (https://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgeme
   nts. pdf). This publication is the work of the authors (Jenalee R. Doom,
   LillyBelle K. Deer, Trudy Mickel, Andrea Infante, and Kenia M. Rivera),
   who will serve as guarantors for the contents of this article. Jenalee
   R. Doom and LillyBelle K. Deer were supported by the National Heart,
   Lung, And Blood Institute (K01HL143159,principal investigator: Jenalee
   R. Doom; F32HL165844, principal investigator: LillyBelle K. Deer). The
   authors are grateful to all the families whotook part in this study, the
   midwives for their help in recruiting them, and the whole ALSPAC team,
   which includes interviewers, computer and laboratory technicians,
   clerical workers, research scientists, volunteers,
   managers,receptionists, and nurses. The authors have no conflicts of
   interest to disclose.This research was funded in whole, or in part, by
   the The UK MedicalResearch Council and Wellcome [Grant 217065/Z/19/Z].
   For the purposeof open access, the author has applied a CC BY public
   copyright license toany Author Accepted Manuscript version arising from
   this submission.
CR Allen KL, 2014, INT J EAT DISORDER, V47, P802, DOI 10.1002/eat.22299
   Arlinghaus KR, 2020, PREV MED REP, V20, DOI 10.1016/j.pmedr.2020.101196
   Balantekin KN, 2012, APPETITE, V59, P298, DOI 10.1016/j.appet.2012.05.016
   Barker ED, 2013, BRIT J PSYCHIAT, V203, P417, DOI 10.1192/bjp.bp.113.129486
   BARNETT BEW, 1983, J PSYCHOSOM RES, V27, P313, DOI 10.1016/0022-3999(83)90054-5
   Beaglehole R, 2007, CIRCULATION, V116, P1871, DOI 10.1161/CIRCULATIONAHA.107.736926
   Boyd A, 2013, INT J EPIDEMIOL, V42, P111, DOI 10.1093/ije/dys064
   Brown G.W., 1978, SOCIAL ORIGINS DEPRE
   Choukas-Bradley S, 2022, CLIN CHILD FAM PSYCH, V25, P681, DOI 10.1007/s10567-022-00404-5
   Croll J, 2002, J ADOLESCENT HEALTH, V31, P166, DOI 10.1016/S1054-139X(02)00368-3
   Dallman MF, 2010, TRENDS ENDOCRIN MET, V21, P159, DOI 10.1016/j.tem.2009.10.004
   Davison TE, 2006, J SOC PSYCHOL, V146, P15, DOI 10.3200/SOCP.146.1.15-30
   Debeuf T, 2018, FRONT PSYCHOL, V9, DOI 10.3389/fpsyg.2018.02657
   Dimitratos SM, 2022, NUTR REV, V80, P1800, DOI 10.1093/nutrit/nuac004
   Dong MX, 2004, CIRCULATION, V110, P1761, DOI 10.1161/01.CIR.0000143074.54995.7F
   Doom JR, 2020, DEV PSYCHOPATHOL, V32, P1864, DOI 10.1017/S0954579420001248
   Doom JR, 2019, J PEDIATR-US, V209, P85, DOI 10.1016/j.jpeds.2019.01.058
   Doom JR, 2017, SOC SCI MED, V188, P166, DOI 10.1016/j.socscimed.2017.06.044
   El-Behadli AF, 2015, BRIT J NUTR, V113, pS55, DOI 10.1017/S000711451400333X
   Ellis JM, 2016, APPETITE, V97, P58, DOI 10.1016/j.appet.2015.11.020
   Farrow CV, 2012, EAT BEHAV, V13, P150, DOI 10.1016/j.eatbeh.2011.11.015
   Finch LE, 2014, NUTRITION IN THE PREVENTION AND TREATMENT OF ABDOMINAL OBESITY, P189, DOI 10.1016/B978-0-12-407869-7.00018-0
   Francis LA, 2001, APPETITE, V37, P231, DOI 10.1006/appe.2001.0427
   Fraser A, 2013, INT J EPIDEMIOL, V42, P97, DOI 10.1093/ije/dys066
   Golding J, 2001, PAEDIATR PERINAT EP, V15, P74
   Goulding AN, 2014, INT J BEHAV NUTR PHY, V11, DOI 10.1186/1479-5868-11-75
   Groth T, 2020, J CHILD ADOLES TRAUM, V13, P443, DOI 10.1007/s40653-019-00275-z
   Gump BB, 2009, DEV PSYCHOPATHOL, V21, P207, DOI 10.1017/S0954579409000133
   Harrist AW, 2013, J DEV BEHAV PEDIATR, V34, P557, DOI 10.1097/DBP.0b013e3182a5095f
   Haynos AF, 2016, J ADOLESCENT HEALTH, V59, P391, DOI 10.1016/j.jadohealth.2016.03.011
   Herle M, 2020, INT J OBESITY, V44, P1766, DOI 10.1038/s41366-020-0581-z
   Hill DC, 2018, APPETITE, V123, P14, DOI 10.1016/j.appet.2017.11.109
   Hill SE, 2016, PSYCHOL SCI, V27, P354, DOI 10.1177/0956797615621901
   Howell RD, 2007, PSYCHOL METHODS, V12, P205, DOI 10.1037/1082-989X.12.2.205
   Hu LT, 1999, STRUCT EQU MODELING, V6, P1, DOI 10.1080/10705519909540118
   Hübel C, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-90644-2
   Huffhines L, 2020, PEDIATR OBES, V15, DOI 10.1111/ijpo.12658
   Jun HJ, 2012, J EPIDEMIOL COMMUN H, V66, P629, DOI 10.1136/jech.2010.110932
   Kidwell KM, 2017, J PEDIATR PSYCHOL, V42, P445, DOI 10.1093/jpepsy/jsw085
   Kininmonth A, 2021, OBES REV, V22, DOI 10.1111/obr.13169
   Kjelsas Einar, 2004, Eat Behav, V5, P13, DOI 10.1016/S1471-0153(03)00057-6
   Kline RB, 2011, Principles and practice of structural equation modelling
   Koning M, 2021, BMC PUBLIC HEALTH, V21, DOI 10.1186/s12889-021-10721-z
   Kral TVE, 2017, J SPEC PEDIATR NURS, V22, DOI 10.1111/jspn.12177
   Lowe MR, 2013, FRONT PSYCHOL, V4, DOI 10.3389/fpsyg.2013.00577
   Lupien SJ, 2009, NAT REV NEUROSCI, V10, P434, DOI 10.1038/nrn2639
   Machado TD, 2013, STRESS, V16, P549, DOI 10.3109/10253890.2013.816841
   Maniam J, 2010, PSYCHONEUROENDOCRINO, V35, P717, DOI 10.1016/j.psyneuen.2009.10.013
   Masip G, 2021, INT J BEHAV NUTR PHY, V18, DOI 10.1186/s12966-021-01205-9
   Mason TB, 2019, HEALTH PSYCHOL, V38, P238, DOI 10.1037/hea0000714
   Matherne CE, 2015, EAT BEHAV, V18, P57, DOI 10.1016/j.eatbeh.2015.04.001
   Melbye EL, 2016, APPETITE, V96, P432, DOI 10.1016/j.appet.2015.09.040
   Michopoulos V, 2015, APPETITE, V91, P129, DOI 10.1016/j.appet.2015.03.036
   Mikkilä V, 2005, BRIT J NUTR, V93, P923, DOI 10.1079/BJN20051418
   Miller AL, 2018, ACAD PEDIATR, V18, P685, DOI 10.1016/j.acap.2018.01.007
   Miller NE, 2022, SSM-POPUL HLTH, V19, DOI 10.1016/j.ssmph.2022.101260
   Moschonis G, 2015, APPETITE, V91, P35, DOI 10.1016/j.appet.2015.03.023
   Munkholm A, 2016, J ADOLESCENT HEALTH, V58, P533, DOI 10.1016/j.jadohealth.2016.01.006
   O'Keeffe LM, 2019, DATA BRIEF, V23, DOI 10.1016/j.dib.2019.01.035
   Paul Elise, 2020, Wellcome Open Res, V5, P108, DOI 10.12688/wellcomeopenres.15925.1
   Racine SE, 2015, INT J EAT DISORDER, V48, P55, DOI 10.1002/eat.22364
   Rodgers RF, 2013, INT J BEHAV NUTR PHY, V10, DOI 10.1186/1479-5868-10-24
   Sarafidis PA, 2007, J HUM HYPERTENS, V21, P709, DOI 10.1038/sj.jhh.1002201
   Scaglioni S, 2011, AM J CLIN NUTR, V94, p2006S, DOI 10.3945/ajcn.110.001685
   Schrepf A, 2014, PSYCHOSOM MED, V76, P327, DOI 10.1097/PSY.0000000000000072
   Schuler BR, 2020, PUBLIC HEALTH NUTR, V23, P2781, DOI 10.1017/S1368980020001366
   Shonkoff JP, 2012, PEDIATRICS, V129, pE232, DOI 10.1542/peds.2011-2663
   Slopen N, 2014, PSYCHOSOM MED, V76, P481, DOI 10.1097/PSY.0000000000000081
   Smyth JM, 2008, INT J EAT DISORDER, V41, P195, DOI 10.1002/eat.20490
   de Lima RMS, 2020, BEHAV BRAIN RES, V379, DOI 10.1016/j.bbr.2019.112399
   Somerville LH, 2010, BRAIN COGNITION, V72, P124, DOI 10.1016/j.bandc.2009.07.003
   St-Hilaire A, 2015, INT J EAT DISORDER, V48, P512, DOI 10.1002/eat.22391
   Steinberger J, 2016, CIRCULATION, V134, pE236, DOI 10.1161/CIR.0000000000000441
   Stice E, 2011, BEHAV RES THER, V49, P622, DOI 10.1016/j.brat.2011.06.009
   Suglia SF, 2021, PREV MED, V153, DOI 10.1016/j.ypmed.2021.106736
   Suglia SF, 2020, J PEDIATR-US, V219, P267, DOI 10.1016/j.jpeds.2019.12.063
   Suglia SF, 2018, CIRCULATION, V137, pE15, DOI 10.1161/CIR.0000000000000536
   Suglia SF, 2012, PEDIATRICS, V129, pE1173, DOI 10.1542/peds.2011-2456
   Tanofsky-Kraff M, 2012, INT J OBESITY, V36, P956, DOI 10.1038/ijo.2011.259
   Tanofsky-Kraff M, 2009, INT J EAT DISORDER, V42, P26, DOI 10.1002/eat.20580
   TENNANT C, 1976, AUST NZ J PSYCHIAT, V10, P27, DOI 10.3109/00048677609159482
   Thomas R, 2020, INT J EAT DISORDER, V53, P1709, DOI 10.1002/eat.23351
   VANSTRIEN T, 1986, INT J EAT DISORDER, V5, P295, DOI 10.1002/1098-108X(198602)5:2<295::AID-EAT2260050209>3.0.CO;2-T
   Warkentin S, 2020, NUTR METAB CARDIOVAS, V30, P810, DOI 10.1016/j.numecd.2020.01.007
   Westall C, 2011, MOTHERHOOD AND POSTNATAL DEPRESSION: NARRATIVES OF WOMEN AND THEIR PARTNERS, P7, DOI 10.1007/978-94-007-1694-0_2
   Wiss DA, 2020, PHYSIOL BEHAV, V223, DOI 10.1016/j.physbeh.2020.112964
   Zhu H, 2016, STRESS HEALTH, V32, P395, DOI 10.1002/smi.2634
   Zimmet P, 2007, PEDIATR DIABETES, V8, P299, DOI 10.1111/j.1399-5448.2007.00271.x
   Ziol-Guest KM, 2009, AM J PUBLIC HEALTH, V99, P527, DOI 10.2105/AJPH.2007.130575
NR 89
TC 5
Z9 5
U1 4
U2 10
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD JUN
PY 2024
VL 43
IS 6
BP 448
EP 461
DI 10.1037/hea0001340
EA FEB 2024
PG 14
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA I0O8U
UT WOS:001174326200001
PM 38407101
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Grossniklaus, DA
   Gary, RA
   Higgins, MK
   Dunbar, SB
AF Grossniklaus, Daurice A.
   Gary, Rebecca A.
   Higgins, Melinda K.
   Dunbar, Sandra B.
TI Biobehavioral and Psychological Differences Between Overweight Adults
   With and Without Waist Circumference Risk
SO RESEARCH IN NURSING & HEALTH
LA English
DT Article
DE obesity; depression; lifestyle change; prevention
ID VISCERAL ADIPOSE-TISSUE; BODY-FAT DISTRIBUTION; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; ABDOMINAL OBESITY; CORTISOL; DEPRESSION;
   ADIPONECTIN; HEALTH; MEN
AB Waist circumference (WC) has emerged as an independent predictor of cardiometabolic disease. The purpose of this study was to examine differences between overweight adults with and without WC risk in four domains: demographic, clinical and biological, psychological, and behavioral. The sample (N = 87) was primarily sedentary, middle-aged, women, and African-Americans. The majority of participants had WC risk, those with WC risk were older, were women, and had higher body mass index, higher morning salivary cortisol levels, and more depressive symptoms than those without WC risk. Caloric and macronutrient intake did not differ between those with and without WC risk. Our findings could lead to the development of targeted interventions to prevent and/or reduce abdominal obesity, thereby reducing cardiometabolic risk. (C) 2010 Wiley Periodicals, Inc. Res Nurs Health 33:539-551, 2010
C1 [Gary, Rebecca A.; Higgins, Melinda K.; Dunbar, Sandra B.] Emory Univ, Nell Hodgson Woodruff Sch Nursing, Atlanta, GA 30322 USA.
C3 Emory University
RP Grossniklaus, DA (corresponding author), 1836 Grist Stone Ct, Atlanta, GA 30307 USA.
RI Higgins, Melinda/B-6459-2013
OI Higgins, Melinda/0000-0001-6579-5885
FU National Institutes of Health; National Institute for Nursing Research;
   National Research Service Award [1F31, NR010159-01A1]; Nurses
   Educational Funds, Inc.; American Nurses Foundation; Southern Nurses
   Research Society; Sigma Theta Tau International, Alpha Epsilon Chapter;
   National Center for Research Resources [UL1RR025008]; Clinical and
   Translational Science [MO1 RR0039]; General Clinical Research Center
FX Contract grant sponsor: National Institutes of Health.Contract grant
   sponsor: National Institute for Nursing Research.Contract grant sponsor:
   National Research Service Award 1F31; Contract grant number:
   NR010159-01A1.Contract grant sponsor: Nurses Educational Funds,
   Inc.Contract grant sponsor: American Nurses Foundation.Contract grant
   sponsor: Southern Nurses Research Society.Contract grant sponsor: Sigma
   Theta Tau International, Alpha Epsilon Chapter.Contract grant sponsor:
   National Institutes of Health.Contract grant sponsor: National Center
   for Research Resources PHS Grant; Contract grant number:
   UL1RR025008.Contract grant sponsor: Clinical and Translational Science
   Award Program and PHS Grant; Contract grant number: MO1 RR0039.Contract
   grant sponsor: General Clinical Research Center Program.
CR Akil H., 1999, Fundamentals of neuroscience, P1127
   [Anonymous], 1998, NIH PUBL
   [Anonymous], 2005, DIET GUID AM 2005
   [Anonymous], 2007, Anthropometry Procedures Manual
   Beck A. T., 1996, BDI 2 BECK DEPRESSIO
   Benton D, 2002, NEUROSCI BIOBEHAV R, V26, P293, DOI 10.1016/S0149-7634(02)00004-0
   Bhasin S, 2003, GROWTH HORM IGF RES, V13, pS63, DOI 10.1016/S1096-6374(03)00058-3
   Bhattacharyya MR, 2008, J PSYCHOSOM RES, V65, P107, DOI 10.1016/j.jpsychores.2008.03.012
   Boden G, 2002, EUR J CLIN INVEST, V32, P14, DOI 10.1046/j.1365-2362.32.s3.3.x
   Brunner R.L., 1997, Obesity assessment: Tools, methods, interpretations, P471
   Carr MC, 2004, J CLIN ENDOCR METAB, V89, P2601, DOI 10.1210/jc.2004-0432
   Carroll JF, 2008, OBESITY, V16, P600, DOI 10.1038/oby.2007.92
   Chambers JA, 2006, PATIENT EDUC COUNS, V62, P79, DOI 10.1016/j.pec.2005.06.007
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cnop M, 2003, DIABETOLOGIA, V46, P459, DOI 10.1007/s00125-003-1074-z
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Cowen PJ, 2002, BRIT J PSYCHIAT, V180, P99, DOI 10.1192/bjp.180.2.99
   Darmon P, 2006, AM J PHYSIOL-ENDOC M, V291, pE995, DOI 10.1152/ajpendo.00654.2005
   de Wit LM, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-14
   DECASTRO JM, 1994, APPETITE, V23, P179, DOI 10.1006/appe.1994.1045
   Després JP, 2000, ARTERIOSCL THROM VAS, V20, P1932, DOI 10.1161/01.ATV.20.8.1932
   Douchi T, 2003, MATURITAS, V46, P133, DOI 10.1016/S0378-5122(03)00162-2
   Duclos M, 2005, OBES RES, V13, P1157, DOI 10.1038/oby.2005.137
   Egede LE, 2007, GEN HOSP PSYCHIAT, V29, P409, DOI 10.1016/j.genhosppsych.2007.06.002
   Epel E, 2001, PSYCHONEUROENDOCRINO, V26, P37, DOI 10.1016/S0306-4530(00)00035-4
   Fallo F, 2004, EUR J ENDOCRINOL, V150, P339, DOI 10.1530/eje.0.1500339
   FRIEDMAN MA, 1995, PSYCHOL BULL, V117, P3, DOI 10.1037/0033-2909.117.1.3
   Gibson RS., 1990, PRINCIPLES NUTR ASSE
   Ginsberg HN, 2006, OBESITY, V14, p41S, DOI 10.1038/oby.2006.281
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Halkjær J, 2006, AM J CLIN NUTR, V84, P789, DOI 10.1093/ajcn/84.4.789
   Harris J., 1919, BIOMETRIC STUDY BASA
   Havel PJ, 2004, DIABETES, V53, pS143, DOI 10.2337/diabetes.53.2007.S143
   Hintze J., 2006, POWER ANAL SAMPLE SI
   Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2548, DOI 10.1210/jc.2004-0395
   KEYS A, 1972, J CHRON DIS, V25, P329, DOI 10.1016/0021-9681(72)90027-6
   Koster A, 2008, AM J EPIDEMIOL, V167, P1465, DOI 10.1093/aje/kwn079
   Kuo LE, 2007, NAT MED, V13, P803, DOI 10.1038/nm1611
   Li C, 2007, OBESITY, V15, P216, DOI 10.1038/oby.2007.505
   Ma J, 2010, OBESITY, V18, P347, DOI 10.1038/oby.2009.213
   Macht M, 2000, APPETITE, V35, P65, DOI 10.1006/appe.2000.0325
   Martin ASG, 2006, AM J CLIN NUTR, V83, p461S, DOI 10.1093/ajcn/83.2.461s
   Meier U, 2004, CLIN CHEM, V50, P1511, DOI 10.1373/clinchem.2004.032482
   Mendoza JA, 2007, DIABETES CARE, V30, P974, DOI 10.2337/dc06-2188
   Molarius A, 1999, INT J OBESITY, V23, P116, DOI 10.1038/sj.ijo.0800772
   Needham BL, 2010, AM J PUBLIC HEALTH, V100, P1040, DOI 10.2105/AJPH.2009.172809
   POULIOT MC, 1994, AM J CARDIOL, V73, P460, DOI 10.1016/0002-9149(94)90676-9
   Puhl R M, 2003, Obes Rev, V4, P213, DOI 10.1046/j.1467-789X.2003.00122.x
   Qi D, 2007, AM J PHYSIOL-ENDOC M, V292, pE654, DOI 10.1152/ajpendo.00453.2006
   REISIN E, 2008, HYPERTENSION PRIMER, P149
   Reynolds RM, 2007, CLIN ENDOCRINOL, V67, P1, DOI 10.1111/j.1365-2265.2007.02838.x
   Roach P, 2005, VASC HEALTH RISK MAN, V1, P301, DOI 10.2147/vhrm.2005.1.4.301
   *SAL, 2009, HIGH SENS SAL CORT E
   Siegel JM, 2000, PREV MED, V31, P232, DOI 10.1006/pmed.2000.0712
   Steptoe A, 2004, INT J OBESITY, V28, P1168, DOI 10.1038/sj.ijo.0802715
   Strickland PL, 2002, BRIT J PSYCHIAT, V180, P168, DOI 10.1192/bjp.180.2.168
   Strine TW, 2008, GEN HOSP PSYCHIAT, V30, P127, DOI 10.1016/j.genhosppsych.2007.12.008
   Travison TG, 2007, CLIN ENDOCRINOL, V67, P71, DOI 10.1111/j.1365-2265.2007.02837.x
   Whooley MA, 2000, NEW ENGL J MED, V343, P1942, DOI 10.1056/NEJM200012283432607
   WRIGHT JD, 2003, ADV DATA VITAL HLTH, V334
NR 60
TC 9
Z9 12
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0160-6891
EI 1098-240X
J9 RES NURS HEALTH
JI Res. Nurs. Health
PD DEC
PY 2010
VL 33
IS 6
BP 539
EP 551
DI 10.1002/nur.20411
PG 13
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 677ZP
UT WOS:000284037000007
PM 21053387
OA Green Submitted, Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Lei, WY
   Yu, HC
   Wen, SH
   Liu, TT
   Yi, CH
   Wang, CC
   Hsu, CS
   Chen, CH
   Chen, CL
   Pace, F
AF Lei, Wei-Yi
   Yu, Hao-Chun
   Wen, Shu-Hui
   Liu, Tso-Tsai
   Yi, Chih-Hsun
   Wang, Chia-Chi
   Hsu, Ching-Sheng
   Chen, Chien-Hwa
   Chen, Chien-Lin
   Pace, Fabio
TI Predictive factors of silent reflux in subjects with erosive esophagitis
SO DIGESTIVE AND LIVER DISEASE
LA English
DT Article
DE Erosive esophagitis; Gastroesophageal reflux; Silent reflux
ID QUALITY-OF-LIFE; GASTROESOPHAGEAL-REFLUX; BARRETTS-ESOPHAGUS;
   RISK-FACTORS; CHINESE POPULATION; METABOLIC SYNDROME; CLINICAL
   CHARACTERISTICS; PSYCHOLOGICAL-FACTORS; GENERAL-POPULATION; SLEEP
   QUALITY
AB Background: Asymptomatic erosive esophagitis by definition is a condition lacking any reflux symptom. Aims: We aimed to investigate the prevalence of asymptomatic erosive esophagitis in a general population undergoing periodic health checkup.
   Methods: Consecutive subjects undergoing a medical checkup were enrolled for evaluation of reflux disease with upper endoscopy and a validated reflux questionnaire. The presence and severity of erosive esophagitis were evaluated. In all subjects, demographic characteristics and biochemical data were recorded, and sleep and psychological characteristics were assessed by means of self-administered Pittsburgh Sleep Quality Index score, Taiwanese Depression Questionnaire score, and State-Trait Anxiety Inventory score.
   Results: Of 2568 subjects eligible for this study, erosive esophagitis was found in 676 subjects (26.3%), in whom the proportions of asymptomatic and symptomatic erosive esophagitis were 59.2% (400 subjects) and 40.8% (276 subjects) respectively. At a univariate analysis, it was found that asymptomatic erosive esophagitis subjects were more frequently of female gender, of older age, with a lower level of education. They also showed less alcohol and tea consumption, less depression, less anxiety, lower serum level of triglyceride, and lower prevalence of metabolic syndrome. Multivariate analysis revealed that female sex (OR = 1.645, p = 0.0146) was a positive predictive factor for asymptomatic erosive esophagitis, whereas higher level of education (OR = 0.564, p = 0.044), higher Taiwanese Depression Questionnaire score (OR = 0.922, p < 0.001), and the presence of metabolic syndrome (OR = 0.625, p = 0.0379) were negative predictive factors.
   Conclusions: Asymptomatic erosive esophagitis is a common feature in otherwise healthy subjects and is independently associated with female gender, lower education level, less depression, and lower prevalence of metabolic syndrome. (C) 2014 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
C1 [Lei, Wei-Yi; Yu, Hao-Chun; Liu, Tso-Tsai; Yi, Chih-Hsun; Chen, Chien-Lin] Buddhist Tzu Chi Med Fdn, Hualien Tzu Chi Hosp, Dept Med, Hualien, Taiwan.
   [Lei, Wei-Yi; Liu, Tso-Tsai; Yi, Chih-Hsun; Chen, Chien-Lin] Tzu Chi Univ, Sch Med, Hualien, Taiwan.
   [Wen, Shu-Hui] Tzu Chi Univ, Coll Med, Dept Publ Hlth, Hualien, Taiwan.
   [Wang, Chia-Chi; Hsu, Ching-Sheng; Chen, Chien-Hwa] Buddhist Tzu Chi Med Fdn, Taipei Tzu Chi Hosp, Dept Internal Med, Div Gastroenterol & Hepatol, Hualien, Taiwan.
   [Wang, Chia-Chi; Hsu, Ching-Sheng; Chen, Chien-Hwa] Tzu Chi Univ, Sch Med, Hualien, Taiwan.
   [Pace, Fabio] L Sacco Univ Hosp, Dept Clin Sci, Div Gastroenterol, Milan, Italy.
C3 Buddhist Tzu Chi General Hospital; Hualien Tzu Chi Hospital; Tzu Chi
   University; Tzu Chi University; Tzu Chi University; University of Milan;
   Luigi Sacco Hospital
RP Chen, CL (corresponding author), Buddhist Tzu Chi Med Fdn, Hualien Tzu Chi Hosp, Dept Med, 707,Sect 3,Chung Yang Rd, Hualien, Taiwan.
EM harry.clchen@msa.hinet.net
RI Lei, Wei-Yi/AAW-8292-2020
OI Wen, Shu-Hui/0000-0003-1402-9114; Chen, Chien-Lin/0000-0002-9084-8210
CR Aina Yemi, 2006, J Am Osteopath Assoc, V106, pS9
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1016/0165-1781(89)90047-4
   Cao Y, 2008, BMC GASTROENTEROL, V8, DOI 10.1186/1471-230X-8-37
   Chang CY, 2009, AM J GASTROENTEROL, V104, P13, DOI 10.1038/ajg.2008.43
   Chen CL, 2010, SCAND J GASTROENTERO, V45, P1150, DOI 10.3109/00365521.2010.496493
   Chen MJ, 2009, J FORMOS MED ASSOC, V108, P53, DOI 10.1016/S0929-6646(09)60032-2
   Cho JH, 2011, J GASTROEN HEPATOL, V26, P1034, DOI 10.1111/j.1440-1746.2011.06686.x
   Choi JY, 2013, EUR J GASTROEN HEPAT, V25, P764, DOI 10.1097/MEG.0b013e32835f594c
   Chung SJ, 2008, GUT, V57, P1360, DOI 10.1136/gut.2007.147090
   El-Serag HB, 2004, GASTROENTEROLOGY, V126, P1692, DOI 10.1053/j.gastro.2004.03.077
   Fass Ronnie, 2006, Curr Gastroenterol Rep, V8, P195, DOI 10.1007/s11894-006-0075-8
   Gerson LB, 2002, GASTROENTEROLOGY, V123, P461, DOI 10.1053/gast.2002.34748
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Hsu CS, 2011, ALIMENT PHARM THER, V34, P994, DOI 10.1111/j.1365-2036.2011.04817.x
   Hsu CS, 2010, HEPATOL INT, V4, P585, DOI 10.1007/s12072-010-9184-4
   Hung HC, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054304
   Jansson C, 2007, ALIMENT PHARM THER, V26, P683, DOI 10.1111/j.1365-2036.2007.03411.x
   Julian LJ, 2011, ARTHRIT CARE RES, V63, pS467, DOI 10.1002/acr.20561
   Kamolz T, 2002, DIS ESOPHAGUS, V15, P199, DOI 10.1046/j.1442-2050.2002.00261.x
   Kim N, 2008, ALIMENT PHARM THER, V27, P173, DOI 10.1111/j.1365-2036.2007.03561.x
   Larauche M, 2011, J NEUROGASTROENTEROL, V17, P213, DOI 10.5056/jnm.2011.17.3.213
   Lee D, 2013, SCAND J GASTROENTERO, V48, P906, DOI 10.3109/00365521.2013.812236
   Lee SP, 2012, J NEUROGASTROENTEROL, V18, P284, DOI 10.5056/jnm.2012.18.3.284
   Lee Y, 2000, Chang Gung Med J, V23, P688
   Lee YC, 2009, GUT, V58, P174, DOI 10.1136/gut.2008.162305
   Locke GR, 1997, GASTROENTEROLOGY, V112, P1448, DOI 10.1016/S0016-5085(97)70025-8
   Lundell LR, 1999, GUT, V45, P172, DOI 10.1136/gut.45.2.172
   Moki F, 2007, ALIMENT PHARM THER, V26, P1069, DOI 10.1111/j.1365-2036.2007.03454.x
   Naliboff BD, 2004, PSYCHOSOM MED, V66, P426, DOI 10.1097/01.psy.0000124756.37520.84
   Nozu T, 2008, J GASTROENTEROL, V43, P27, DOI 10.1007/s00535-007-2120-2
   Oh JH, 2009, GUT LIVER, V3, P259, DOI 10.5009/gnl.2009.3.4.259
   Ohara Syuichi, 2005, Nihon Shokakibyo Gakkai Zasshi, V102, P1010
   Ou JL, 2012, J CHIN MED ASSOC, V75, P60, DOI 10.1016/j.jcma.2011.12.008
   Peng S, 2009, ENDOSCOPY, V41, P1011, DOI 10.1055/s-0029-1215291
   Ronkainen J, 2005, SCAND J GASTROENTERO, V40, P275, DOI 10.1080/00365520510011579
   Shaw MJ, 2001, AM J GASTROENTEROL, V96, P52
   Tack J, 2012, ALIMENT PHARM THER, V35, P1257, DOI 10.1111/j.1365-2036.2012.05086.x
   Tseng PH, 2008, J CLIN GASTROENTEROL, V42, P1074, DOI 10.1097/MCG.0b013e31809e7126
   Vakil N, 2006, AM J GASTROENTEROL, V101, P1900, DOI 10.1111/j.1572-0241.2006.00630.x
   Wang FW, 2010, DIGEST DIS SCI, V55, P1320, DOI 10.1007/s10620-009-0888-z
   Wang PC, 2012, J GASTROEN HEPATOL, V27, P586, DOI 10.1111/j.1440-1746.2011.06881.x
   Zagari RM, 2008, GUT, V57, P1354, DOI 10.1136/gut.2007.145177
   Zou DW, 2011, SCAND J GASTROENTERO, V46, P133, DOI 10.3109/00365521.2010.521888
NR 43
TC 20
Z9 21
U1 1
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1590-8658
EI 1878-3562
J9 DIGEST LIVER DIS
JI Dig. Liver Dis.
PD JAN
PY 2015
VL 47
IS 1
BP 24
EP 29
DI 10.1016/j.dld.2014.09.017
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AX3KJ
UT WOS:000346838000008
PM 25308612
DA 2025-06-11
ER

PT J
AU Byrne, DG
   Espnes, GA
AF Byrne, D. G.
   Espnes, Geir Arild
TI Occupational stress and cardiovascular disease
SO STRESS AND HEALTH
LA English
DT Article
DE occupation; stress; cardiovascular disease
ID CORONARY-HEART-DISEASE; EFFORT-REWARD IMBALANCE; MYOCARDIAL-INFARCTION
   RISK; PSYCHOSOCIAL WORK-ENVIRONMENT; JOB STRAIN; BLOOD-PRESSURE;
   DECISION LATITUDE; METABOLIC SYNDROME; PSYCHOLOGICAL STRESS; PERCEIVED
   STRESS
AB Links between occupational stress and cardiovascular risk have long been asserted. This paper reviews the evidence from the simple notion of occupational level and type as a risk through to the more theoretically sophisticated models of occupational stress as a determinant of cardiovascular risk and disease. It maps measures of occupational stress against the three related end points of coronary risk profiles, hypertension and clinical cardiovascular disease. Taken broadly, the evidence is supportive of postulated links. The persuasiveness of the evidence now points to intervention studies in the workplace as the next major focus of research. Copyrigbt (C) 2008 John Wiley & Sons, Ltd.
C1 [Byrne, D. G.] Australian Natl Univ, Sch Psychol, Canberra, ACT 0200, Australia.
   [Espnes, Geir Arild] Norwegian Univ Sci & Technol, Sch Social Work & Hlth Sci, Trondheim, Norway.
C3 Australian National University; Norwegian University of Science &
   Technology (NTNU)
RP Byrne, DG (corresponding author), Australian Natl Univ, Sch Psychol, GPO Box 4, Canberra, ACT 0200, Australia.
EM don.byrne@anu.edu.au
CR ALFREDSSON L, 1982, SOC SCI MED, V16, P463, DOI 10.1016/0277-9536(82)90054-5
   ALFREDSSON L, 1983, SOC SCI MED, V17, P1497, DOI 10.1016/0277-9536(83)90094-1
   Alfredsson L, 2002, SCAND J WORK ENV HEA, V28, P238, DOI 10.5271/sjweh.671
   Bongard S, 2005, J PSYCHOSOM RES, V58, P43, DOI 10.1016/j.jpsychores.2004.04.370
   Bosma H, 1998, AM J PUBLIC HEALTH, V88, P68, DOI 10.2105/AJPH.88.1.68
   Brunner EJ, 2004, J EPIDEMIOL COMMUN H, V58, P1019, DOI 10.1136/jech.2003.016881
   Byrne D.G, 2007, HDB PERSONALITY THEO
   BYRNE DG, 2000, STRESS HLTH RES CLIN
   Campbell CY, 2007, AM J CARDIOL, V100, P840, DOI 10.1016/j.amjcard.2007.04.018
   Cesana G, 2003, PSYCHOSOM MED, V65, P558, DOI 10.1097/01.PSY.0000041473.03828.67
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Clays E, 2005, J OCCUP ENVIRON MED, V47, P878, DOI 10.1097/01.jom.0000171056.22917.ad
   De Vogli R, 2007, J EPIDEMIOL COMMUN H, V61, P513, DOI 10.1136/jech.2006.052563
   Demiral Y, 2006, J OCCUP HEALTH, V48, P332, DOI 10.1539/joh.48.332
   Din-Dzietham R, 2004, SOC SCI MED, V58, P449, DOI 10.1016/S0277-9536(03)00211-9
   Greiner BA, 2004, SOC SCI MED, V59, P1081, DOI 10.1016/j.socscimed.2003.12.006
   Hallqvist J, 1998, SOC SCI MED, V46, P1405, DOI 10.1016/S0277-9536(97)10084-3
   Hart P.M., 2001, Handbook of industrial, work and organizational psychology, V2, P93, DOI [DOI 10.4135/9781848608368.N6, 10.4135/9781848608368.n6]
   Heslop P, 2002, SOC SCI MED, V54, P1589, DOI 10.1016/S0277-9536(01)00138-1
   John U, 2006, OCCUP ENVIRON MED, V63, P207, DOI 10.1136/oem.2005.020966
   JOHNSON JV, 1988, AM J PUBLIC HEALTH, V78, P1336, DOI 10.2105/AJPH.78.10.1336
   Jönsson D, 2003, STRESS HEALTH, V19, P149, DOI 10.1002/smi.966
   Kang MG, 2005, PREV MED, V40, P583, DOI 10.1016/j.ypmed.2004.07.018
   Kang MG, 2004, YONSEI MED J, V45, P838, DOI 10.3349/ymj.2004.45.5.838
   KARASEK RA, 1979, ADMIN SCI QUART, V24, P285, DOI 10.2307/2392498
   Kinnunen M., 2006, J INDIVID DIFFER, V27, P151
   Kittel F, 2002, EUR HEART J, V23, P1841, DOI 10.1053/euhj.2002.3258
   Kivimäki M, 2005, ARCH INTERN MED, V165, P2245, DOI 10.1001/archinte.165.19.2245
   Kjeldsen SE, 2006, BLOOD PRESSURE, V15, P93, DOI 10.1080/08037050600750157
   Kouvonen A, 2005, J EPIDEMIOL COMMUN H, V59, P63, DOI 10.1136/jech.2004.019752
   Kouvonen A, 2007, J EPIDEMIOL COMMUN H, V61, P427, DOI 10.1136/jech.2007.061739
   Kuper H, 2003, J EPIDEMIOL COMMUN H, V57, P147, DOI 10.1136/jech.57.2.147
   Landsbergis PA, 2003, SCAND J WORK ENV HEA, V29, P206, DOI 10.5271/sjweh.723
   LAZARUS RS, 1991, J SOC BEHAV PERS, V6, P1
   Lee S, 2002, INT J EPIDEMIOL, V31, P1147, DOI 10.1093/ije/31.6.1147
   Leone A, 2007, CURR PHARM DESIGN, V13, P1661, DOI 10.2174/138161207780831347
   Levenstein S, 2001, ARCH INTERN MED, V161, P1341, DOI 10.1001/archinte.161.10.1341
   Malinauskiene V, 2005, SCAND J WORK ENV HEA, V31, P218, DOI 10.5271/sjweh.872
   Melamed S, 2006, PSYCHOL BULL, V132, P327, DOI 10.1037/0033-2909.132.3.327
   Mendis S, 2007, J HYPERTENS, V25, P1578, DOI 10.1097/HJH.0b013e3282861fd3
   Metcalfe C, 2003, BRIT J HEALTH PSYCH, V8, P83, DOI 10.1348/135910703762879228
   Ng DM, 2003, HEALTH PSYCHOL, V22, P638, DOI 10.1037/0278-6133.22.6.638
   O'Connor DB, 2001, FAM PRACT, V18, P92, DOI 10.1093/fampra/18.1.92
   Öhlin B, 2007, J HYPERTENS, V25, P1613
   Panagiotakos D B, 2003, Cent Eur J Public Health, V11, P25
   Peter R, 1999, SCAND J WORK ENV HEA, V25, P376, DOI 10.5271/sjweh.448
   Peter R, 2006, INT J BEHAV MED, V13, P34, DOI 10.1207/s15327558ijbm1301_5
   Peter R, 1998, J EPIDEMIOL COMMUN H, V52, P540, DOI 10.1136/jech.52.9.540
   Peter R, 1997, SOC SCI MED, V45, P1111, DOI 10.1016/S0277-9536(97)00039-7
   Peter R, 2002, J EPIDEMIOL COMMUN H, V56, P294, DOI 10.1136/jech.56.4.294
   Radi S, 2005, OCCUP ENVIRON MED, V62, P711, DOI 10.1136/oem.2004.012955
   Rau R, 2001, J Occup Health Psychol, V6, P171, DOI 10.1037/1076-8998.6.3.171
   Rose G, 2006, OCCUP MED-OXFORD, V56, P386, DOI 10.1093/occmed/kql037
   Sacker A, 2001, PSYCHOL MED, V31, P279, DOI 10.1017/S0033291701003270
   Siegrist J, 2004, SOC SCI MED, V58, P1483, DOI 10.1016/S0277-9536(03)00351-4
   SIEGRIST J, 1990, WORK STRESS, V4, P295, DOI 10.1080/02678379008256992
   Siegrist J, 2005, PSYCHONEUROENDOCRINO, V30, P1033, DOI 10.1016/j.psyneuen.2005.03.017
   SIEGRIST J, 1982, SOC SCI MED, V16, P443, DOI 10.1016/0277-9536(82)90052-1
   Smith TW, 2002, J CONSULT CLIN PSYCH, V70, P548, DOI 10.1037//0022-006X.70.3.548
   Stanley RO, 2006, STRESS HEALTH, V22, P139, DOI 10.1002/smi.1115
   Steptoe A, 2004, PSYCHOSOM MED, V66, P323, DOI 10.1097/01.psy.0000126198.67070.72
   Su CT, 2001, INT J CARDIOL, V81, P181, DOI 10.1016/S0167-5273(01)00565-4
   Sulsky L., 2005, WORK STRESS
   Taylor R, 2006, EUR J CARDIOV PREV R, V13, P760, DOI 10.1097/01.hjr.0000220581.42387.d4
   THEORELL T, 1993, SCAND J WORK ENV HEA, V19, P313, DOI 10.5271/sjweh.1469
   Theorell T, 1996, J Occup Health Psychol, V1, P9, DOI 10.1037/1076-8998.1.1.9
   Theorell T, 2002, EUR HEART J, V23, P1799, DOI 10.1053/euhj.2002.3293
   Theorell T, 2000, PSYCHOTHER PSYCHOSOM, V69, P86, DOI 10.1159/000012371
   Tsutsumi A, 1999, J EPIDEMIOL COMMUN H, V53, P348, DOI 10.1136/jech.53.6.348
   Tsutsumi A, 2003, INT J BEHAV MED, V10, P125, DOI 10.1207/S15327558IJBM1002_03
   Tsutsumi A, 1998, INT J BEHAV MED, V5, P295, DOI 10.1207/s15327558ijbm0504_4
   Tsutsumi A, 2001, OCCUP ENVIRON MED, V58, P367, DOI 10.1136/oem.58.6.367
   van Vegchel N, 2005, SOC SCI MED, V60, P1117, DOI 10.1016/j.socscimed.2004.06.043
   Wang HX, 2007, J INTERN MED, V261, P245, DOI 10.1111/j.1365-2796.2006.01759.x
   Westerlund H, 2004, EUR J PUBLIC HEALTH, V14, P37, DOI 10.1093/eurpub/14.1.37
   Woodward M, 2007, J THROMB HAEMOST, V5, P1795, DOI 10.1111/j.1538-7836.2007.02677.x
   Yang H, 2006, HYPERTENSION, V48, P744, DOI 10.1161/01.HYP.0000238327.41911.52
NR 77
TC 39
Z9 56
U1 1
U2 54
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1532-3005
EI 1532-2998
J9 STRESS HEALTH
JI Stress Health
PD AUG
PY 2008
VL 24
IS 3
BP 231
EP 238
DI 10.1002/smi.1203
PG 8
WC Psychology, Applied; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 353QY
UT WOS:000259584500009
DA 2025-06-11
ER

PT J
AU Mujkanovic, J
   Warming, PE
   Kessing, LV
   Kober, LV
   Winkel, BG
   Lynge, TH
   Tfelt-Hansen, J
AF Mujkanovic, Jasmin
   Warming, Peder Emil
   Kessing, Lars Vedel
   Kober, Lars Valeur
   Winkel, Bo Gregers
   Lynge, T. H.
   Tfelt-Hansen, Jacob
TI Nationwide burden of sudden cardiac death among patients with a
   psychiatric disorder
SO HEART
LA English
DT Article
DE SUDDEN CARDIAC DEATH; Epidemiology; Quality of Health Care; Risk
   Factors; Metabolic Syndrome
ID SCHIZOPHRENIA; DEPRESSION; MORTALITY; GENDER; RISK
AB Background Patients with psychiatric disorders have increased all-cause mortality compared with the general population. Previous research has shown that there is a fourfold increased risk of sudden cardiac death (SCD) among the young. Objective To investigate the incidence of SCD in patients with psychiatric disorders aged 18-90 years in the Danish population by systematically reviewing all deaths in 1 year. Methods We examined all deaths in Denmark among residents aged 18-90 years in 2010 by reviewing death certificates and autopsy reports. All deaths were categorised as non-SCD or SCD based on the available information. Psychiatric disorder was defined according to International Classification of Diseases, 10th revision criteria or by redemption of a prescription for psychotropic medication within 1 year. Results Of 4.3 million residents in 2010, we observed 45 703 deaths, of which 6002 were due to SCD. Overall, the incidence rate ratio of SCD was 1.79-6.45 times higher among patients with psychiatric disorders than in the general population and was age dependent (p<0.001 across all age groups). When adjusting for age, sex and comorbidities, psychiatric disorders were independently associated with SCD, with a HR of 2.31 (2.19 to 2.43, p<0.001), and HR was highest among patients with schizophrenic disorders, with a HR of 4.51 (3.95 to 5.16, p <0.001). Furthermore, 18-year-old patients with a psychiatric disorder had an expected 10-year excess loss of life. Patients aged 18-40 with a psychiatric disorder had 13% of excess life years lost caused by SCD. Conclusion In this study, the rate of SCD in patients with psychiatric disorders is higher across all age groups than in the general population. Having a psychiatric disorder is independently associated with SCD. Patients with schizophrenic disease had the highest rates of SCD. Life expectancy for an 18-year old with a psychiatric disorder is estimated to be 10 years shorter in comparison with those without this disorder.
C1 [Mujkanovic, Jasmin; Warming, Peder Emil; Kober, Lars Valeur; Winkel, Bo Gregers; Lynge, T. H.; Tfelt-Hansen, Jacob] Rigshosp Hjertecentret, Dept Cardiol, Copenhagen, Hovedstaden, Denmark.
   [Mujkanovic, Jasmin] Univ Copenhagen, Dept Forens Med, Copenhagen, Region Hovedsta, Denmark.
   [Kessing, Lars Vedel] Rigshosp, Dept Psychiat, Copenhagen, Denmark.
   [Tfelt-Hansen, Jacob] Univ Copenhagen, Fac Hlth Sci, Dept Med & Surg, Dept Forens Med, Copenhagen, Region Hovedsta, Denmark.
C3 University of Copenhagen; University of Copenhagen; Copenhagen
   University Hospital; Rigshospitalet; University of Copenhagen
RP Mujkanovic, J (corresponding author), Rigshosp Hjertecentret, Dept Cardiol, Copenhagen, Hovedstaden, Denmark.; Mujkanovic, J (corresponding author), Univ Copenhagen, Dept Forens Med, Copenhagen, Region Hovedsta, Denmark.
EM jasmin.mujkanovic@regionh.dk; peder.emil.warming@regionh.dk;
   Lars.Vedel.Kessing@regionh.dk; lars.kober@regionh.dk;
   bo.winkel@regionh.dk; thomas.hadberg.lynge.02@regionh.dk;
   jacob.tfelt@regionh.dk
RI Tfelt-Hansen, Jacob/AAU-8691-2020; Kessing, Lars/JNS-2493-2023; Winkel,
   Bo/AAZ-9190-2021; Warming, Peder Emil/AFL-9482-2022
OI Kessing, Lars/0000-0001-9377-9436; Tfelt-Hansen,
   Jacob/0000-0003-3895-9316
CR Aktaa S, 2023, EUROPACE, V25, P199, DOI 10.1093/europace/euac114
   Andersen PK, 2017, STAT MED, V36, P3573, DOI 10.1002/sim.7357
   Barcella CA, 2019, RESUSCITATION, V143, P180, DOI 10.1016/j.resuscitation.2019.07.008
   Bjune T, 2018, EUROPACE, V20, P614, DOI 10.1093/europace/euw435
   Doherty DT, 2010, BRIT J HEALTH PSYCH, V15, P213, DOI 10.1348/135910709X457423
   Fazel S, 2014, LANCET PSYCHIAT, V1, P44, DOI 10.1016/S2215-0366(14)70223-8
   Firth J, 2019, LANCET PSYCHIAT, V6, P675, DOI 10.1016/S2215-0366(19)30132-4
   Hauck TS, 2020, CAN J PSYCHIAT, V65, P454, DOI 10.1177/0706743720904845
   Ifteni P, 2014, SCHIZOPHR RES, V155, P72, DOI 10.1016/j.schres.2014.03.011
   Jespersen CHB, 2023, EUROPACE, V25, DOI 10.1093/europace/euad112
   Kessing LV, 2023, JAMA PSYCHIAT, V80, P1000, DOI 10.1001/jamapsychiatry.2023.2206
   Kessing LV, 2015, BIPOLAR DISORD, V17, P543, DOI 10.1111/bdi.12296
   Kroll J, 2022, EUROPACE, V24, P620, DOI 10.1093/europace/euab252
   Laursen TM, 2007, J CLIN PSYCHIAT, V68, P899, DOI 10.4088/JCP.v68n0612
   Lynge TH, 2021, HEART RHYTHM, V18, P1657, DOI 10.1016/j.hrthm.2021.05.005
   Lynge TH, 2020, EUR HEART J, V41, P2699, DOI 10.1093/eurheartj/ehz891
   Martin LA, 2013, JAMA PSYCHIAT, V70, P1100, DOI 10.1001/jamapsychiatry.2013.1985
   Okayasu H, 2021, NEUROPSYCH DIS TREAT, V17, P239, DOI 10.2147/NDT.S287042
   Paratz ED, 2023, JACC-CLIN ELECTROPHY, V9, P1310, DOI 10.1016/j.jacep.2023.01.026
   Penninx BWJH, 2017, NEUROSCI BIOBEHAV R, V74, P277, DOI 10.1016/j.neubiorev.2016.07.003
   Plana-Ripoll O, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0228073
   Plana-Ripoll O, 2019, LANCET, V394, P1827, DOI 10.1016/S0140-6736(19)32316-5
   Risgaard Bjarke, 2017, JACC Clin Electrophysiol, V3, P473, DOI 10.1016/j.jacep.2016.12.023
   Risgaard B, 2015, J CLIN PSYCHIAT, V76, pE1122, DOI 10.4088/JCP.14m09742
   Salk RH, 2017, PSYCHOL BULL, V143, P783, DOI 10.1037/bul0000102
   Rossi JLS, 2022, DIABETES-METAB RES, V38, DOI 10.1002/dmrr.3502
   Simpson TF, 2020, JAMA INTERN MED, V180, P698, DOI 10.1001/jamainternmed.2020.0148
   Sweeting J, 2013, SCHIZOPHR RES, V150, P398, DOI 10.1016/j.schres.2013.08.029
   Warming PE, 2022, AM HEART J, V245, P117, DOI 10.1016/j.ahj.2021.12.008
   Watanabe J, 2017, J CLIN PSYCHOPHARM, V37, P452, DOI 10.1097/JCP.0000000000000724
NR 30
TC 4
Z9 4
U1 2
U2 2
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1355-6037
EI 1468-201X
J9 HEART
JI Heart
PD DEC
PY 2024
VL 110
IS 23
BP 1365
EP 1371
DI 10.1136/heartjnl-2024-324092
EA OCT 2024
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA Q5W8H
UT WOS:001357945300001
PM 39438152
OA hybrid
DA 2025-06-11
ER

PT J
AU Slopen, N
   Strizich, G
   Hua, SM
   Gallo, LC
   Chae, DH
   Priest, N
   Gurka, MJ
   Bangdiwala, SI
   Bravin, JI
   Chambers, EC
   Daviglus, ML
   Llabre, MM
   Carnethon, MR
   Isasi, CR
AF Slopen, Natalie
   Strizich, Garrett
   Hua, Simin
   Gallo, Linda C.
   Chae, David H.
   Priest, Naomi
   Gurka, Matthew J.
   Bangdiwala, Shrikant, I
   Bravin, Julia, I
   Chambers, Earle C.
   Daviglus, Martha L.
   Llabre, Maria M.
   Carnethon, Mercedes R.
   Isasi, Carmen R.
TI Maternal experiences of ethnic discrimination and child cardiometabolic
   outcomes in the Study of Latino Youth
SO ANNALS OF EPIDEMIOLOGY
LA English
DT Article
DE Study of Latino Youth; Discrimination; Children; Cardiometabolic health
ID C-REACTIVE PROTEIN; CARDIOVASCULAR RISK; MENTAL-HEALTH; RACISM; FAMILY;
   REDUCTION; PARENTS; DISEASE; DESIGN; STROKE
AB Purpose: Limited research has examined maternal experiences of racial/ethnic discrimination in relation to child cardiometabolic health. In this study, we investigated whether maternal experiences of ethnic discrimination were associated with cardiometabolic risk in Hispanic/Latino youth several years later.
   Methods: Our sample included 1146 youth (8-16 years) from the Study of Latino Youth (2012-2014), who were children of the Hispanic Community Health Study/Study of Latinos participants (2008-2011). We used regression models to examine the prospective associations between maternal report of ethnic discrimination in relation to her child's body mass index (BMI) z-score, metabolic syndrome score (MetS), and high sensitivity C-reactive protein (hsCRP) levels 2 years later.
   Results: Maternal ethnic discrimination was associated with youth hsCRP, but not BMI or MetS (P-values >.05). Adjusting for age, nativity, and national background, maternal ethnic discrimination was associated with higher (log) hsCRP levels (beta = 0.18, 95% CI = 0.04 to 0.32) in children. This association was robust to adjustment for maternal and household characteristics (beta = 0.17, 95% CI = 0.04 to 0.31), as well as maternal depression and maternal BMI.
   Conclusions: Maternal ethnic discrimination is associated with inflammation among Hispanic/Latino youth, and not BMI z-score or MetS. Studies are needed to address temporality and pathways. (C) 2019 Elsevier Inc. All rights reserved.
C1 [Slopen, Natalie] Univ Maryland, Dept Epidemiol & Biostat, College Pk, MD 20742 USA.
   [Strizich, Garrett; Hua, Simin; Isasi, Carmen R.] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA.
   [Gallo, Linda C.; Bravin, Julia, I] San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA.
   [Chae, David H.] Auburn Univ, Dept Human Dev & Family Studies, Auburn, AL 36849 USA.
   [Priest, Naomi] Australian Natl Univ, Coll Arts & Social Sci, Ctr Social Res & Methods, Canberra, ACT, Australia.
   [Priest, Naomi] Murdoch Childrens Res Inst, Populat Hlth, Melbourne, Vic, Australia.
   [Gurka, Matthew J.] Univ Florida, Dept Hlth Outcomes & Biomed Informat, Gainesville, FL USA.
   [Bangdiwala, Shrikant, I] McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada.
   [Chambers, Earle C.] Dept Family & Social Med, Bronx, NY USA.
   [Daviglus, Martha L.] Univ Illinois, Coll Med, Inst Minor Hlth Res, Chicago, IL USA.
   [Llabre, Maria M.] Univ Miami, Dept Psychol, POB 248185, Coral Gables, FL 33124 USA.
   [Carnethon, Mercedes R.] Northwestern Univ, Dept Prevent Med, Chicago, IL 60611 USA.
C3 University System of Maryland; University of Maryland College Park;
   Yeshiva University; Montefiore Medical Center; Albert Einstein College
   of Medicine; California State University System; San Diego State
   University; Auburn University System; Auburn University; Australian
   National University; Murdoch Children's Research Institute; State
   University System of Florida; University of Florida; McMaster
   University; University of Illinois System; University of Illinois
   Chicago; University of Illinois Chicago Hospital; University of Miami;
   Northwestern University
RP Slopen, N (corresponding author), Univ Maryland, Epidemiol & Biostat, College Pk, MD 20742 USA.
EM nslopen@umd.edu
RI Chae, David/F-6956-2015
OI Slopen, Natalie/0000-0002-5644-6007; Gallo, Linda
   C./0000-0002-3678-5888; Priest, Naomi/0000-0002-2246-0644; Carnethon,
   Mercedes/0000-0001-7035-0848
FU National Heart, Lung, and Blood Institute, United States [R01HL102130];
   National Heart, Lung, and Blood Institute (NHLBI) [N01-HC65233,
   N01-HC65234, N01-HC65235, N01-HC65236, N01-HC65237]; Graduate School,
   University of Maryland, United States; W. K. Kellogg Foundation
   [P3022586]; NHLBI [R01HL120960]
FX The SOL Youth Study was supported by Grant Number R01HL102130 from the
   National Heart, Lung, and Blood Institute, United States. The children
   in SOL Youth are drawn from the study of adults: The Hispanic Community
   Health Study/Study of Latinos, which was supported by contracts from the
   National Heart, Lung, and Blood Institute (NHLBI) to the University of
   North Carolina, United States (N01-HC65233), University of Miami, United
   States (N01-HC65234), Albert Einstein College of Medicine, United States
   (N01-HC65235), Northwestern University, United States (N01-HC65236), and
   San Diego State University, United States (N01-HC65237). N.S. was
   supported by a Research and Scholarship Award from the Graduate School,
   University of Maryland, United States and Grant P3022586 from the W. K.
   Kellogg Foundation. M.J.G. was supported by NHLBI grant R01HL120960.
CR ANDRESEN EM, 1994, AM J PREV MED, V10, P77, DOI 10.1016/S0749-3797(18)30622-6
   Bécares L, 2015, SOC SCI MED, V142, P128, DOI 10.1016/j.socscimed.2015.08.025
   Brondolo E, 2005, J APPL SOC PSYCHOL, V35, P335, DOI 10.1111/j.1559-1816.2005.tb02124.x
   Buckley TM, 2005, J CLIN ENDOCR METAB, V90, P3106, DOI 10.1210/jc.2004-1056
   Camhi SM, 2010, INT J PEDIATR OBES, V5, P122, DOI 10.3109/17477160903111763
   Caughy MO, 2004, AM J PUBLIC HEALTH, V94, P2118, DOI 10.2105/AJPH.94.12.2118
   Coll CG, 1996, CHILD DEV, V67, P1891, DOI 10.2307/1131600
   DeBoer MD, 2015, J AM COLL CARDIOL, V66, P756, DOI 10.1016/j.jacc.2015.05.061
   Devine PG, 2012, J EXP SOC PSYCHOL, V48, P1267, DOI 10.1016/j.jesp.2012.06.003
   ELDER GH, 1994, SOC PSYCHOL QUART, V57, P4
   Espinoza G, 2016, CHILD DEV, V87, P1079, DOI 10.1111/cdev.12521
   Evans GW, 2013, PSYCHOL BULL, V139, P1342, DOI 10.1037/a0031808
   Ford KR, 2013, CHILD DEV, V84, P485, DOI 10.1111/j.1467-8624.2012.01864.x
   Gassman-Pines A, 2015, CHILD DEV, V86, P1175, DOI 10.1111/cdev.12378
   Goosby BJ, 2015, AM J HUM BIOL, V27, P546, DOI 10.1002/ajhb.22683
   Gurka MJ, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-128
   Harrell JP, 2003, AM J PUBLIC HEALTH, V93, P243, DOI 10.2105/AJPH.93.2.243
   Havranek EP, 2015, CIRCULATION, V132, P873, DOI 10.1161/CIR.0000000000000228
   Heard-Garris NJ, 2018, SOC SCI MED, V199, P230, DOI 10.1016/j.socscimed.2017.04.018
   Isasi CR, 2016, J PEDIATR-US, V176, P121, DOI 10.1016/j.jpeds.2016.05.037
   Isasi CR, 2014, ANN EPIDEMIOL, V24, P29, DOI 10.1016/j.annepidem.2013.08.008
   Järvisalo MJ, 2002, ARTERIOSCL THROM VAS, V22, P1323, DOI 10.1161/01.ATV.0000024222.06463.21
   Jones CP, 2000, AM J PUBLIC HEALTH, V90, P1212, DOI 10.2105/AJPH.90.8.1212
   Juonala M, 2006, ARTERIOSCL THROM VAS, V26, P1883, DOI 10.1161/01.ATV.0000228818.11968.7a
   Kelly Y, 2013, J EPIDEMIOL COMMUN H, V67, P35, DOI 10.1136/jech-2011-200814
   Lavange LM, 2010, ANN EPIDEMIOL, V20, P642, DOI 10.1016/j.annepidem.2010.05.006
   Lorenzo-Blanco EI, 2019, CHILD DEV, V90, P506, DOI 10.1111/cdev.12914
   Lorenzo-Blanco EI, 2016, J FAM PSYCHOL, V30, P966, DOI 10.1037/fam0000223
   Macgregor-Bowles I, 2017, AIMS PUBLIC HEALTH, V4, P139, DOI 10.3934/publichealth.2017.2.139
   Mozaffarian D, 2016, CIRCULATION, V133, pE38, DOI 10.1161/CIR.0000000000000350
   Paluck EL, 2009, ANNU REV PSYCHOL, V60, P339, DOI 10.1146/annurev.psych.60.110707.163607
   Priest N, 2013, SOC SCI MED, V95, P115, DOI 10.1016/j.socscimed.2012.11.031
   Priest N, 2012, J EPIDEMIOL COMMUN H, V66, P440, DOI 10.1136/jech.2010.117366
   Rodriguez CJ, 2014, CIRCULATION, V130, P593, DOI 10.1161/CIR.0000000000000071
   Slopen N, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0064418
   Slopen N, 2012, BRAIN BEHAV IMMUN, V26, P239, DOI 10.1016/j.bbi.2011.11.003
   Tabák AG, 2010, EUR J ENDOCRINOL, V163, P89, DOI 10.1530/EJE-10-0277
   Thayer ZM, 2015, SOC SCI MED, V128, P36, DOI 10.1016/j.socscimed.2015.01.003
   Tran AGTT, 2014, AM J COMMUN PSYCHOL, V53, P37, DOI 10.1007/s10464-013-9607-1
   Umaña-Taylor AJ, 2007, J ADOLESCENCE, V30, P549, DOI 10.1016/j.adolescence.2006.08.002
   Walker SE, 2012, NUTR METAB CARDIOVAS, V22, P141, DOI 10.1016/j.numecd.2010.05.006
   Wassertheil-Smoller S, 2014, ANN EPIDEMIOL, V24, P822, DOI 10.1016/j.annepidem.2014.09.003
   Williams DR, 2013, AM BEHAV SCI, V57, P1152, DOI 10.1177/0002764213487340
NR 43
TC 9
Z9 11
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1047-2797
EI 1873-2585
J9 ANN EPIDEMIOL
JI Ann. Epidemiol.
PD JUN
PY 2019
VL 34
BP 52
EP 57
DI 10.1016/j.annepidem.2019.03.011
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA ID0GS
UT WOS:000471362300010
PM 31060896
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chrousos, GP
AF Chrousos, GP
TI The role of stress and the hypothalamic-pituitary-adrenal axis in the
   pathogenesis of the metabolic syndrome: neuro-endocrine and target
   tissue-related causes
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article; Proceedings Paper
CT 8th International Congress on Endocrinology of Obesity Basic, Clinical
   and Therapeutic Aspects
CY SEP, 1998
CL VENICE, ITALY
DE CRH; HPA; glucocorticoids; cortisol; Cushing's syndrome
ID CORTICOTROPIN-RELEASING HORMONE; GLUCOCORTICOID RECEPTOR GENE; BODY-FAT
   DISTRIBUTION; CORTISOL SECRETION; BIOCHEMICAL MANIFESTATIONS;
   CUSHINGS-SYNDROME; PLASMA-CORTISOL; OBESE WOMEN; WEIGHT-LOSS; DEPRESSION
AB The stress system coordinates the adaptive response of the organism to real or perceived stressors. The main components of the stress system are the corticotropin-releasing hormone (CRH) and locus ceruleus-norepinephrine/autonomic (LC/NE) systems and their peripheral effectors, the hypothalamic-pituitary-adrenal (HPA) axis, and the limbs of the autonomic system. Activation of the stress system leads to behavioral and peripheral changes that improve the ability of the organism to adjust homeostasis and increase its chances for survival. Thus, CRH and the LC/NE system stimulate arousal and attention, as well as the mesocorticolimbic dopaminergic system, which is involved in anticipatory and reward phenomena, and the amygdala, which are responsible for the generation of fear. Hypothalamic CRH plays an important role in inhibiting gonadotropin-releasing hormone secretion during stress, while via somatostatin it also inhibits growth hormone, thyrotropin-releasing hormone and thyrotropin secretion, suppressing thus reproduction, growth and thyroid function. Glucocorticoids directly inhibit pituitary gonadotropin, growth hormone and thyrotropin secretion and make the target tissues of sex steroids and growth factors resistant to these substances. In addition, glucocorticoids stimulate hepatic gluconeogenesis, and inhibit or potentiate insulin actions on skeletal muscle and adipose tissue respectively, ultimately promoting visceral adiposity and the metabolic syndrome. Glucocorticoids also have direct effects on the bone, inhibiting osteoblastic activity and causing osteoporosis. Obese subjects with psychiatric manifestations ranging from those of melancholic depression to anxiety with perception of 'uncontrollable' stress, frequently have mild hypercortisolism, while carefully screened obese subjects with no such manifestations are eucortisolemic. The former may have stress-induced glucocorticoid-mediated visceral obesity and metabolic syndrome manifestations, which in the extreme may be called a pseudo-Cushing state that needs to be differentiated from frank Cushing syndrome. Stress-induced hypercortisolism and visceral obesity and their cardiovascular and other sequelae increase the all-cause mortality risk of affected subjects by 2-3-fold and curtail their life expectancy by several years.
C1 Nichhd, Pediat Endocrinol Sect, PREB, NIH, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver
   National Institute of Child Health & Human Development (NICHD)
RP Chrousos, GP (corresponding author), Nichhd, Pediat Endocrinol Sect, PREB, NIH, 10 Ctr Dr MSC 1583,Bldg 10,Room 1D42, Bethesda, MD 20892 USA.
RI Chrousos, George/G-8702-2011
CR ANDA R, 1993, EPIDEMIOLOGY, V4, P285, DOI 10.1097/00001648-199307000-00003
   BAMBERGER CM, 1996, ENDOCR REV, V17, P221
   BAREFOOT JC, 1993, ACP J CLUB, V93, P1976
   Chrousos GP, 1998, J CLIN ENDOCR METAB, V83, P1842, DOI 10.1210/jc.83.6.1842
   CHROUSOS GP, 1995, NEW ENGL J MED, V332, P1351, DOI 10.1056/NEJM199505183322008
   CHROUSOS GP, 1993, ANN INTERN MED, V119, P1113, DOI 10.7326/0003-4819-119-11-199312010-00009
   CHROUSOS GP, 1992, JAMA-J AM MED ASSOC, V267, P1244, DOI 10.1001/jama.267.9.1244
   Delaunay F, 1997, J CLIN INVEST, V100, P2094, DOI 10.1172/JCI119743
   Friedman TC, 1996, ENDOCR J, V43, P645, DOI 10.1507/endocrj.43.645
   GOLD PW, 1988, NEW ENGL J MED, V319, P348, DOI 10.1056/NEJM198808113190606
   GOLD PW, 1988, NEW ENGL J MED, V319, P413, DOI 10.1056/NEJM198808183190706
   HALBREICH U, 1984, PSYCHIAT RES, V13, P221, DOI 10.1016/0165-1781(84)90037-4
   Huizenga NATM, 1998, J CLIN ENDOCR METAB, V83, P47, DOI 10.1210/jc.83.1.47
   Huizenga NATM, 1998, J CLIN ENDOCR METAB, V83, P144, DOI 10.1210/jc.83.1.144
   KARL M, 1993, J CLIN ENDOCR METAB, V76, P683, DOI 10.1210/jc.76.3.683
   KISSEBAH AH, 1994, PHYSIOL REV, V74, P761, DOI 10.1152/physrev.1994.74.4.761
   KLING MA, 1991, J CLIN ENDOCR METAB, V72, P260, DOI 10.1210/jcem-72-2-260
   MARIN P, 1992, METABOLISM, V41, P882, DOI 10.1016/0026-0495(92)90171-6
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   Michelson D, 1996, NEW ENGL J MED, V335, P1176, DOI 10.1056/NEJM199610173351602
   Musselman DL, 1998, ARCH GEN PSYCHIAT, V55, P580, DOI 10.1001/archpsyc.55.7.580
   Panarelli M, 1998, J CLIN ENDOCR METAB, V83, P1846, DOI 10.1210/jc.83.6.1846
   PAPANICOLAOU D, 1998, 80 ANN M END SOC 24
   Papanicolaou DA, 1998, ANN INTERN MED, V128, P127, DOI 10.7326/0003-4819-128-2-199801150-00009
   PASQUALI R, 1993, J CLIN ENDOCR METAB, V77, P341, DOI 10.1210/jc.77.2.341
   PAVLOV EP, 1986, J CLIN ENDOCR METAB, V62, P767, DOI 10.1210/jcem-62-4-767
   Rosmond R, 1998, J CLIN ENDOCR METAB, V83, P1853, DOI 10.1210/jc.83.6.1853
   Sarlis NJ, 1997, J CLIN ENDOCR METAB, V82, P1274, DOI 10.1210/jc.82.4.1274
   SILVERSTONE PH, 1990, J PSYCHOSOM RES, V34, P651, DOI 10.1016/0022-3999(90)90109-H
   Tsigos C, 1996, ANNU REV MED, V47, P443
   VanCauter E, 1996, J CLIN ENDOCR METAB, V81, P2468, DOI 10.1210/jc.81.7.2468
   Walker BR, 1998, HYPERTENSION, V31, P891, DOI 10.1161/01.HYP.31.4.891
   WALTMAN C, 1991, J CLIN ENDOCR METAB, V73, P495, DOI 10.1210/jcem-73-3-495
   WATT GCM, 1992, J HYPERTENS, V10, P473, DOI 10.1097/00004872-199205000-00011
   WEAVER JU, 1992, J MOL ENDOCRINOL, V9, P295, DOI 10.1677/jme.0.0090295
   YANOVSKI JA, 1993, JAMA-J AM MED ASSOC, V269, P2232, DOI 10.1001/jama.1993.03500170062035
   Yanovski JA, 1997, J CLIN ENDOCR METAB, V82, P1874, DOI 10.1210/jc.82.6.1874
   YANOVSKI SZ, 1993, J CLIN ENDOCR METAB, V76, P675, DOI 10.1210/jc.76.3.675
NR 38
TC 462
Z9 544
U1 1
U2 54
PU NATURE PUBLISHING GROUP
PI BASINGSTOKE
PA HOUNDMILLS, BASINGSTOKE RG21 6XS, HAMPSHIRE, ENGLAND
SN 0307-0565
J9 INT J OBESITY
JI Int. J. Obes.
PD JUN
PY 2000
VL 24
SU 2
BP S50
EP S55
DI 10.1038/sj.ijo.0801278
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 335NW
UT WOS:000088250400012
PM 10997609
DA 2025-06-11
ER

PT J
AU Cai, YL
   Zhou, SY
   Fan, SH
   Yang, Y
   Tian, KM
   Luo, L
   Deng, RL
   Dai, XY
   Wang, YY
   Zhu, ML
   Liu, T
AF Cai, Yulan
   Zhou, Shiyu
   Fan, Shangheng
   Yang, Yan
   Tian, Kunming
   Luo, Lei
   Deng, Renli
   Dai, Xingyu
   Wang, Yiying
   Zhu, Minglan
   Liu, Tao
TI The multimorbidity association of metabolic syndrome and depression on
   type 2 diabetes: a general population cohort study in Southwest China
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE type 2 diabetes; metabolic syndrome; depression; complication;
   multimorbidity; cohort study
ID LIFE-STYLE; RISK; MELLITUS; SYMPTOMS; ANTIDEPRESSANTS; INFLAMMATION;
   DIAGNOSIS; ANXIETY; OBESITY; ADULTS
AB Background Metabolic syndrome(MetS) and depression are independently associated with type 2 diabetes (T2DM) risk. However, little is known about the combined effect of MetS and depression on the risk of T2DM. The present study aims to prospectively explore the impact of MetS and depression on T2DM susceptibility among the Chinese general population.Methods 6489 general population without T2DM adults in Southwest China were recruited from 2010 to 2012. Depression and MetS were prospectively assessed using a 9-item Patient Health Questionnaire(PHQ-9) and Guideline for the prevention and treatment of type 2 diabetes mellitus in China (2020 edition) (CDS2020) during 2016-2020, respectively. Modified Poisson regression models were conducted to estimate relative risk(RR) and 95% confidence intervals (95%CI) for independent and combined associations of MetS and depression with an incidence of T2DM.Results During a median follow-up of 6.6 years, 678 cases of T2DM were documented. Individuals with MetS were 1.33 times more likely to develop T2DM than those without MetS. The corresponding RR(95%CI) for depression with no depression was 1.45(1.22-1.72). Notably, compared with no MetS or depression, the multivariate-adjusted RR for a combined effect of MetS and depression on the risk of T2DM was 2.11(1.39-3.22). Moreover, an increased risk of T2DM was more apparent in those >= 60 years, males, and overweight.Conclusions Individuals with multimorbidity of MetS and depression are at a higher risk of T2DM compared with those with no MetS or depression.
C1 [Cai, Yulan; Fan, Shangheng; Yang, Yan] Zunyi Med Univ, Affiliated Hosp 2, Dept Endocrinol & Metab, Zunyi, Guizhou, Peoples R China.
   [Zhou, Shiyu; Deng, Renli; Zhu, Minglan] Zunyi Med Univ, Affiliated Hosp, Dept Nursing, Zunyi, Guizhou, Peoples R China.
   [Tian, Kunming; Luo, Lei] Zunyi Med Univ, Sch Publ Hlth, Dept Prevent Med, Zunyi, Guizhou, Peoples R China.
   [Dai, Xingyu] Zunyi Med Univ, Sch Clin Med, Zunyi, Guizhou, Peoples R China.
   [Wang, Yiying; Liu, Tao] Dept Chron Dis Prevent & Control, Guizhou Dis Prevent & Control, Guiyang, Guizhou, Peoples R China.
C3 Zunyi Medical University; Zunyi Medical University; Zunyi Medical
   University; Zunyi Medical University
RP Zhu, ML (corresponding author), Zunyi Med Univ, Affiliated Hosp, Dept Nursing, Zunyi, Guizhou, Peoples R China.; Liu, T (corresponding author), Dept Chron Dis Prevent & Control, Guizhou Dis Prevent & Control, Guiyang, Guizhou, Peoples R China.
EM lls04561@163.com; liutao9099No_2@163.com
RI Zhou, Shiyu/KRQ-2397-2024
FU National Natural Science Foundation of China10.13039/501100001809
FX We thank all the Guizhou Population Health Cohort Study participants for
   their lasting support and enthusiastic collaboration. We are also
   indebted to all workers for their valuable contributions.
CR Almeida OP, 2019, MATURITAS, V128, P4, DOI 10.1016/j.maturitas.2019.06.009
   [中华医学会糖尿病学分会 Chinese Diabetes Society], 2021, [中华内分泌代谢杂志, Chinese Journal of Endocrinology and Metabolism], V37, P311
   Antonio-Villa NE, 2020, DIABETIC MED, V37, P1192, DOI 10.1111/dme.14274
   Boden G, 2002, EUR J CLIN INVEST, V32, P14, DOI 10.1046/j.1365-2362.32.s3.3.x
   Chatterjee S, 2017, LANCET, V389, P2239, DOI 10.1016/S0140-6736(17)30058-2
   Chen ML, 2022, OBES REV, V23, DOI 10.1111/obr.13340
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   Cornier MA, 2008, ENDOCR REV, V29, P777, DOI 10.1210/er.2008-0024
   Deng YY, 2024, NUTRIENTS, V16, DOI 10.3390/nu16040547
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Fu XY, 2023, AGING-US, V15, P5917, DOI 10.18632/aging.204847
   Grajales D, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8111336
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   He C, 2020, PSYCHOTHER PSYCHOSOM, V89, P25, DOI 10.1159/000502294
   Hu FB, 2001, NEW ENGL J MED, V345, P790, DOI 10.1056/NEJMoa010492
   Kan C, 2013, DIABETES CARE, V36, P480, DOI 10.2337/dc12-1442
   Kempf K, 2006, ANN NY ACAD SCI, V1084, P30, DOI 10.1196/annals.1372.012
   Kianersi S, 2023, ANN INTERN MED, V176, P1330, DOI 10.7326/M23-0728
   Kiecolt-Glaser JK, 2015, AM J PSYCHIAT, V172, P1075, DOI 10.1176/appi.ajp.2015.15020152
   Kunugi H, 2023, PSYCHIAT CLIN NEUROS, V77, P420, DOI 10.1111/pcn.13551
   Lee MK, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-59203-z
   Lee YB, 2020, J DIABETES INVEST, V11, P1583, DOI 10.1111/jdi.13304
   Ley SH, 2009, CAN MED ASSOC J, V180, P617, DOI 10.1503/cmaj.080972
   Lontchi-Yimagou E, 2013, CURR DIABETES REP, V13, P435, DOI 10.1007/s11892-013-0375-y
   Luo YN, 2019, J AFFECT DISORDERS, V246, P783, DOI 10.1016/j.jad.2018.12.131
   Lv XY, 2024, BMC PUBLIC HEALTH, V24, DOI 10.1186/s12889-024-17891-6
   Mastrototaro L, 2021, METABOLISM, V125, DOI 10.1016/j.metabol.2021.154892
   Meng RW, 2018, J AFFECT DISORDERS, V234, P59, DOI 10.1016/j.jad.2018.02.052
   Niles AN, 2015, J PSYCHOSOM RES, V78, P109, DOI 10.1016/j.jpsychores.2014.11.018
   Pan L, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.959860
   Pimenta AM, 2021, J AFFECT DISORDERS, V284, P183, DOI 10.1016/j.jad.2021.02.002
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Ranasinghe P, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4041-1
   Saeedi P, 2019, DIABETES RES CLIN PR, V157, DOI 10.1016/j.diabres.2019.107843
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Somani BL, 1999, DIABETES CARE, V22, P366, DOI 10.2337/diacare.22.2.366b
   Sun YJ, 2022, BMC PSYCHIATRY, V22, DOI 10.1186/s12888-021-03661-w
   Tang ZT, 2024, J AFFECT DISORDERS, V352, P267, DOI 10.1016/j.jad.2024.02.055
   Tinetti ME, 2012, JAMA-J AM MED ASSOC, V307, P2493, DOI 10.1001/jama.2012.5265
   Wang LM, 2021, JAMA-J AM MED ASSOC, V326, P2498, DOI 10.1001/jama.2021.22208
   Wang SS, 2016, J ZHEJIANG UNIV-SC B, V17, P649, DOI 10.1631/jzus.B1600341
   Wang XL, 2022, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.812104
   Wang YQ, 2021, J AFFECT DISORDERS, V287, P41, DOI 10.1016/j.jad.2021.03.023
   Williams R, 2020, DIABETES RES CLIN PR, V162, DOI 10.1016/j.diabres.2020.108072
   Wu YL, 2023, J DIABETES, V15, P994, DOI 10.1111/1753-0407.13453
   Zhang M, 2021, TRANSL PSYCHIAT, V11, DOI 10.1038/s41398-021-01759-z
   Zhang P, 2016, BMC FAM PRACT, V17, DOI 10.1186/s12875-016-0435-x
   Zheng Y, 2018, NAT REV ENDOCRINOL, V14, P88, DOI 10.1038/nrendo.2017.151
   Zimmerman M, 2019, JAMA-J AM MED ASSOC, V322, P2125, DOI 10.1001/jama.2019.15883
NR 49
TC 2
Z9 2
U1 2
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JUL 5
PY 2024
VL 15
AR 1399859
DI 10.3389/fendo.2024.1399859
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA YV6B5
UT WOS:001271288400001
PM 39036053
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Maes, M
   Kubera, M
   Obuchowiczwa, E
   Goehler, L
   Brzeszcz, J
AF Maes, Michael
   Kubera, Marta
   Obuchowiczwa, Ewa
   Goehler, Lisa
   Brzeszcz, Joanna
TI Depression's multiple comorbidities explained by (neuro)inflammatory and
   oxidative & nitrosative stress pathways
SO NEUROENDOCRINOLOGY LETTERS
LA English
DT Review
DE depression; cytokines; inflammation; oxidative stress; comorbidity;
   medical illness
ID INFLAMMATORY-BOWEL-DISEASE; SYSTEMIC-LUPUS-ERYTHEMATOSUS; OBSTRUCTIVE
   PULMONARY-DISEASE; ILLNESS RATING-SCALE; CARDIOVASCULAR RISK-FACTORS;
   CHRONIC MEDICAL ILLNESS; ANXIETY-LIKE BEHAVIOR; QUALITY-OF-LIFE;
   PARKINSONS-DISEASE; RHEUMATOID-ARTHRITIS
AB There is now evidence that depression, as characterized by melancholic symptoms, anxiety, and fatigue and somatic (F&S) symptoms, is the clinical expression of peripheral cell-mediated activation, inflammation and induction of oxidative and nitrosative stress (IO&NS) pathways and of central microglial activation, decreased neurogenesis and increased apoptosis. This review gives an explanation for the multiple "co-morbidities" between depression and a large variety of a) brain disorders related to neurodegeneration, e.g. Alzheimer's, Parkinson's and Huntington's disease, multiple sclerosis and stroke; b) medical disorders, such as cardiovascular disorder, chronic fatigue syndrome, chronic obstructive pulmonary disease, rheumatoid arthritis, psoriasis, systemic lupus erythematosus, inflammatory bowel disease, irritable bowel syndrome, leaky gut, diabetes type 1 and 2, obesity and the metabolic syndrome, and HIV infection; and c) conditions, such as hemodialysis, interferon-a-based immunotherapy, the postnatal period and psychosocial stressors. The common denominator of all those disorders/conditions is the presence of microglial activation and/or activation of peripheral IO&NS pathways. There is evidence that shared peripheral and / or central IO&NS pathways underpin the pathophysiology of depression and the previously mentioned disorders and that activation of these IO&NS pathways contributes to shared risk. The IO&NS pathways function as a smoke sensor that detect threats in the peripheral and central parts of the body and signal these threats as melancholic, anxiety, and fatigue and somatic (F&S) symptoms. The presence of concomitant depression is strongly associated with a lower quality of life and increased morbidity and mortality in medical disorders. This may be explained since depression contributes to increased (neuro)inflammatory burden and may therefore drive the inflammatory and degenerative progression. It is concluded that the activation of peripheral and! or central IO&NS pathways may explain the co-occurrence of depression with the above disorders. This shows that depression belongs to the spectrum of inflammatory and degenerative disorders.
C1 [Maes, Michael] Maes Clin TRIA, Bangkok 10310, Thailand.
   [Kubera, Marta] Polish Acad Sci, Inst Pharmacol, Dept Expt Endocrinol, PL-31343 Krakow, Poland.
   [Obuchowiczwa, Ewa] Med Univ Silesia, Dept Pharmacol, PL-40752 Katowice, Poland.
   [Goehler, Lisa] Univ Virginia, Sch Nursing, Ctr Study Complementary & Alternat Therapies, Charlottesville, VA 22904 USA.
   [Brzeszcz, Joanna] Oil & Gas Inst, PL-31503 Krakow, Poland.
C3 Polish Academy of Sciences; Medical University of Silesia; University of
   Virginia; Oil & Gas Institute - National Research Institute
RP Maes, M (corresponding author), Maes Clin TRIA, 998 Rimklongsamsen Rd, Bangkok 10310, Thailand.
RI Maes, Michael/B-8546-2011; Obuchowicz, Ewa/AGM-1556-2022
OI Kubera, Marta/0000-0003-4401-5055; Obuchowicz, Ewa/0000-0002-8684-2377;
   Maes, Michael/0000-0002-2012-871X; Brzeszcz, Joanna/0000-0003-3951-3375
CR Al-Shukaili AK, 2006, SAUDI MED J, V27, P1642
   ALCOCERVARELA J, 1992, LUPUS, V1, P111, DOI 10.1177/096120339200100209
   ALEXANDROVSKY YA, 1988, ZH NEVROPATOL PSIKH, V88, P95
   ALLEN AD, 1986, J CLIN PSYCHIAT, V47, P133
   Altindag O, 2007, CLIN BIOCHEM, V40, P167, DOI 10.1016/j.clinbiochem.2006.10.006
   Alzoghaibi Mohammed A, 2007, Saudi J Gastroenterol, V13, P187, DOI 10.4103/1319-3767.36750
   Amore M, 2007, ARCH GERONTOL GERIAT, V44, P23, DOI 10.1016/j.archger.2007.01.004
   Anisman H, 2002, BRAIN BEHAV IMMUN, V16, P513, DOI 10.1016/S0889-1591(02)00009-0
   Anisman H, 2009, J PSYCHIATR NEUROSCI, V34, P4
   [Anonymous], PROG NEUROPSYCHOPHAR
   [Anonymous], PROG NEUROPSYCHOPHAR
   Bachen EA, 2009, ARTHRIT RHEUM-ARTHR, V61, P822, DOI 10.1002/art.24519
   Banks WA, 2005, CURR PHARM DESIGN, V11, P973, DOI 10.2174/1381612053381684
   Barbaro MPF, 2007, INT J IMMUNOPATH PH, V20, P753, DOI 10.1177/039463200702000411
   Bhasin M, 2007, BMC IMMUNOL, V8, DOI 10.1186/1471-2172-8-10
   Bonaccorso S, 2002, J CLIN PSYCHOPHARM, V22, P86, DOI 10.1097/00004714-200202000-00014
   Bonaccorso S, 2001, PSYCHIAT RES, V105, P45, DOI 10.1016/S0165-1781(01)00315-8
   Bruce Travis O, 2008, Curr Psychiatry Rep, V10, P258, DOI 10.1007/s11920-008-0042-1
   Cagnin A, 2001, LANCET, V358, P461, DOI 10.1016/S0140-6736(01)05625-2
   Caradonna L, 2000, J ENDOTOXIN RES, V6, P205, DOI 10.1177/09680519000060030101
   CASTEX N, 1995, BRAIN RES, V688, P149, DOI 10.1016/0006-8993(95)00526-V
   Chakrabarti SK, 2009, OBESITY, V17, P1657, DOI 10.1038/oby.2009.192
   Chaouat A, 2009, CHEST, V136, P678, DOI 10.1378/chest.08-2420
   CHARLSON ME, 1987, J CHRON DIS, V40, P373, DOI 10.1016/0021-9681(87)90171-8
   Chen PJ, 2007, INT J GERIATR PSYCH, V22, P543, DOI 10.1002/gps.1712
   Chwastiak LA, 2007, PSYCHIAT CLIN N AM, V30, P803, DOI 10.1016/j.psc.2007.07.003
   Coaccioli S, 2009, CLIN TER, V160, P467
   Creed F, 2005, BRIT J PSYCHIAT, V186, P507, DOI 10.1192/bjp.186.6.507
   Dantzer R, 2004, EUR J PHARMACOL, V500, P399, DOI 10.1016/j.ejphar.2004.07.040
   Dasgupta S, 2005, J BIOL CHEM, V280, P32609, DOI 10.1074/jbc.M500299200
   Dayas CV, 2001, EUR J NEUROSCI, V14, P1143, DOI 10.1046/j.0953-816x.2001.01733.x
   de Groot V, 2003, J CLIN EPIDEMIOL, V56, P221, DOI 10.1016/S0895-4356(02)00585-1
   De Marchi N, 2000, HARVARD REV PSYCHIAT, V7, P278, DOI 10.1093/hrp/7.5.278
   Dincer Y, 2007, DIGEST DIS SCI, V52, P1636, DOI 10.1007/s10620-006-9386-8
   Drevets WC, 2008, BRAIN STRUCT FUNCT, V213, P93, DOI 10.1007/s00429-008-0189-x
   Drevets WC, 2001, CURR OPIN NEUROBIOL, V11, P240, DOI 10.1016/S0959-4388(00)00203-8
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   Duncan BB, 2003, DIABETES, V52, P1799, DOI 10.2337/diabetes.52.7.1799
   Eagan TML, 2010, EUR RESPIR J, V35, P540, DOI 10.1183/09031936.00088209
   Egede LE, 2010, DIABETES RES CLIN PR, V87, P302, DOI 10.1016/j.diabres.2010.01.024
   España RA, 2006, J COMP NEUROL, V496, P668, DOI 10.1002/cne.20946
   Esposito K, 2004, NUTR METAB CARDIOVAS, V14, P228, DOI 10.1016/S0939-4753(04)80048-6
   FEINSTEIN AR, 1970, J CHRON DIS, V23, P455, DOI 10.1016/0021-9681(70)90054-8
   Fenton WS, 2006, CURR OPIN PSYCHIATR, V19, P421, DOI 10.1097/01.yco.0000228765.33356.9f
   Filakovic P, 2008, PSYCHIAT DANUB, V20, P419
   First MB, 2005, PSYCHOPATHOLOGY, V38, P206, DOI 10.1159/000086093
   GARDINER KR, 1995, GUT, V36, P897, DOI 10.1136/gut.36.6.897
   GARDNER A, 2010, PROG NEUROPSYCHOPHAR
   Gaykema RPA, 2008, NEUROSCIENCE, V152, P273, DOI 10.1016/j.neuroscience.2007.10.042
   Gaykema RPA, 2007, BRAIN RES, V1130, P130, DOI 10.1016/j.brainres.2006.10.084
   Gaykema RPA, 2009, BRAIN RES, V1294, P61, DOI 10.1016/j.brainres.2009.07.076
   Geerlings MI, 2000, BRIT J PSYCHIAT, V176, P568, DOI 10.1192/bjp.176.6.568
   Gerhard A, 2006, NEUROBIOL DIS, V21, P404, DOI 10.1016/j.nbd.2005.08.002
   Ghia JE, 2009, GASTROENTEROLOGY, V136, P2280, DOI 10.1053/j.gastro.2009.02.069
   Glass CK, 2010, CELL, V140, P918, DOI 10.1016/j.cell.2010.02.016
   Goehler LE, 2005, BRAIN BEHAV IMMUN, V19, P334, DOI 10.1016/j.bbi.2004.09.002
   Goehler LE, 2000, AUTON NEUROSCI-BASIC, V85, P49, DOI 10.1016/S1566-0702(00)00219-8
   Goehler LE, 2008, BRAIN BEHAV IMMUN, V22, P354, DOI 10.1016/j.bbi.2007.08.009
   Goehler LE, 2007, BRAIN BEHAV IMMUN, V21, P721, DOI 10.1016/j.bbi.2007.02.005
   Graff LA, 2009, INFLAMM BOWEL DIS, V15, P1105, DOI 10.1002/ibd.20873
   Greco CM, 2009, RHEUMATOLOGY, V48, P576, DOI 10.1093/rheumatology/kep020
   Grey M, 2002, J PSYCHOSOM RES, V53, P907, DOI 10.1016/S0022-3999(02)00312-4
   Guenther L, 2009, J CUTAN MED SURG, V13, pS77, DOI 10.2310/7750.2009.00024
   Hajszán T, 2002, J COMP NEUROL, V449, P141, DOI 10.1002/cne.10279
   Hayes J, 2010, DERMATOL THER, V23, P174, DOI 10.1111/j.1529-8019.2010.01312.x
   Hillilä MT, 2008, ALIMENT PHARM THER, V28, P648, DOI 10.1111/j.1365-2036.2008.03771.x
   Hirsch EC, 2007, J NEURAL TRANSM-SUPP, P87
   Hirsch EC, 2003, J NEURAL TRANSM-SUPP, P89, DOI 10.1007/978-3-7091-0643-3_6
   Holvoet P, 2008, FUTURE LIPIDOL, V3, P637, DOI 10.2217/17460875.3.6.637
   Huang TL, 2007, PSYCHIAT RES, V152, P277, DOI 10.1016/j.psychres.2005.07.038
   Huang TL, 2006, PSYCHIAT CLIN NEUROS, V60, P687, DOI 10.1111/j.1440-1819.2006.01583.x
   Hudon C, 2005, J CLIN EPIDEMIOL, V58, P603, DOI 10.1016/j.jclinepi.2004.10.017
   HUEHNCHEN P, 2010, GLIA
   Huff W, 2003, NERVENARZT, V74, P104, DOI 10.1007/s00115-002-1417-x
   Hunter RL, 2007, J NEUROCHEM, V100, P1375, DOI 10.1111/j.1471-4159.2006.04327.x
   Huysman F, 2009, ACTA CHIR BELG, V109, P587
   Ibrahim S, 2008, AM J NEPHROL, V28, P784, DOI 10.1159/000131101
   Irie M, 2001, INT ARCH OCC ENV HEA, V74, P153, DOI 10.1007/s004200000209
   Jennings JH, 2009, LUNG, V187, P128, DOI 10.1007/s00408-009-9135-9
   Jin R, 2010, J LEUKOCYTE BIOL, V87, P779, DOI 10.1189/jlb.1109766
   Kagami S, 2010, J INVEST DERMATOL, V130, pS122
   Kalender B, 2006, NEPHRON CLIN PRACT, V102, pC115, DOI 10.1159/000089669
   Kalpakcioglu B, 2008, CLIN RHEUMATOL, V27, P141, DOI 10.1007/s10067-007-0746-3
   Kaneto H, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/453892
   Kang JH, 2010, EUR J NEUROL, V17, P1215, DOI 10.1111/j.1468-1331.2010.02971.x
   Kanner AM, 2005, EPILEPSY BEHAV, V6, P303, DOI 10.1016/j.yebeh.2005.02.008
   Katon W, 2007, GEN HOSP PSYCHIAT, V29, P147, DOI 10.1016/j.genhosppsych.2006.11.005
   Katon W, 2009, PSYCHOSOMATICS, V50, P570, DOI 10.1176/appi.psy.50.6.570
   Kim YS, 2006, EXP MOL MED, V38, P333, DOI 10.1038/emm.2006.40
   Ko GJ, 2010, NEPHRON CLIN PRACT, V116, pC29, DOI 10.1159/000314548
   Kolsum Umme, 2009, Int J Chron Obstruct Pulmon Dis, V4, P149
   Konsman JP, 2005, EUR J NEUROSCI, V21, P2752, DOI 10.1111/j.1460-9568.2005.04102.x
   Kovács Z, 2007, INT J PSYCHIAT MED, V37, P245, DOI 10.2190/PM.37.3.a
   KREUTZBERG GW, 1995, ARZNEIMITTEL-FORSCH, V45-1, P357
   Kriz Jasna, 2006, Critical Reviews in Neurobiology, V18, P145
   Krzystek-Korpacka M, 2010, INFLAMM BOWEL DIS, V16, P1467, DOI 10.1002/ibd.21234
   Ku IA, 2009, CIRC J, V73, P977, DOI 10.1253/circj.CJ-09-0274
   KUBERA M, 2010, PROG NEUROPSYCHOPHAR
   Laudisio A, 2009, J GERIATR PSYCH NEUR, V22, P215, DOI 10.1177/0891988709335793
   LEMAY LG, 1990, PHYSIOL BEHAV, V47, P957, DOI 10.1016/0031-9384(90)90024-X
   Leonard BE, 2006, NEUROTOX RES, V10, P149
   Leonard BE, 2009, HUM PSYCHOPHARM CLIN, V24, P165, DOI 10.1002/hup.1011
   Leppavuori Antero, 2010, Duodecim, V126, P521
   LINN BS, 1968, J AM GERIATR SOC, V16, P622, DOI 10.1111/j.1532-5415.1968.tb02103.x
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Lustman PJ, 2005, J DIABETES COMPLICAT, V19, P113, DOI 10.1016/j.jdiacomp.2004.01.002
   Lyte M, 2006, PHYSIOL BEHAV, V89, P350, DOI 10.1016/j.physbeh.2006.06.019
   Maes M, 2000, PSYCHONEUROENDOCRINO, V25, P121, DOI 10.1016/S0306-4530(99)00043-8
   MAES M, 1995, PSYCHONEUROENDOCRINO, V20, P111, DOI 10.1016/0306-4530(94)00066-J
   Maes M, 1999, CURR OPIN PSYCHIATR, V12, P695, DOI 10.1097/00001504-199911000-00019
   MAES M, 1995, PROG NEURO-PSYCHOPH, V19, P11, DOI 10.1016/0278-5846(94)00101-M
   Maes M, 2002, LIFE SCI, V71, P1837, DOI 10.1016/S0024-3205(02)01853-2
   MAES M, 1990, PSYCHIAT RES, V34, P43, DOI 10.1016/0165-1781(90)90057-C
   Maes M, 2001, CLIN SCI, V101, P193, DOI 10.1042/CS20010157
   Maes M, 1998, CYTOKINE, V10, P313, DOI 10.1006/cyto.1997.0290
   Maes M, 2008, NEUROENDOCRINOL LETT, V29, P117
   Maes M, 2009, NEUROENDOCRINOL LETT, V30, P564
   Maes M, 2009, METAB BRAIN DIS, V24, P27, DOI 10.1007/s11011-008-9118-1
   Maj Mario, 2005, Br J Psychiatry, V186, P182, DOI 10.1192/bjp.186.3.182
   Mearin F, 2009, GASTROENT HEPAT-BARC, V32, P364, DOI 10.1016/j.gastrohep.2008.12.007
   MENZA MA, 1993, BIOL PSYCHIAT, V34, P465, DOI 10.1016/0006-3223(93)90237-8
   Menza Matthew, 2006, Curr Psychiatry Rep, V8, P234, DOI 10.1007/s11920-006-0029-8
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Michaud K, 2007, BEST PRACT RES CL RH, V21, P885, DOI 10.1016/j.berh.2007.06.002
   Micozkadioglu H, 2006, NEPHROLOGY, V11, P502, DOI 10.1111/j.1440-1797.2006.00664.x
   Mikkelsen RL, 2004, NORD J PSYCHIAT, V58, P65, DOI 10.1080/08039480310000824
   Mikocka-Walus AA, 2007, INFLAMM BOWEL DIS, V13, P225, DOI 10.1002/ibd.20062
   MILLER MD, 1992, PSYCHIAT RES, V41, P237, DOI 10.1016/0165-1781(92)90005-N
   MINAMI M, 1991, NEUROSCI LETT, V123, P254, DOI 10.1016/0304-3940(91)90944-O
   Miskulin DC, 2001, KIDNEY INT, V60, P1498, DOI 10.1046/j.1523-1755.2001.00954.x
   Modrego PJ, 2004, ARCH NEUROL-CHICAGO, V61, P1290, DOI 10.1001/archneur.61.8.1290
   Montinaro V, 2010, CLIN NEPHROL, V73, P36, DOI 10.2379/CNX06364
   Naldi L, 2010, DERMATOL THER, V23, P114, DOI 10.1111/j.1529-8019.2010.01304.x
   Neumann H, 2001, GLIA, V36, P191, DOI 10.1002/glia.1108
   Ng TP, 2009, RESP MED, V103, P895, DOI 10.1016/j.rmed.2008.12.010
   Nguyen KT, 1998, J NEUROSCI, V18, P2239
   Norwood Rachel, 2005, COPD, V2, P185
   Owe-Larsson B, 2009, AFR J PSYCHIATRY, V12, P115
   Ownby RL, 2006, ARCH GEN PSYCHIAT, V63, P530, DOI 10.1001/archpsyc.63.5.530
   Pavlov VA, 2005, BRAIN BEHAV IMMUN, V19, P493, DOI 10.1016/j.bbi.2005.03.015
   Pertsov S S, 1995, Biull Eksp Biol Med, V120, P244
   Pinteaux-Jones F, 2008, J NEUROCHEM, V106, P442, DOI 10.1111/j.1471-4159.2008.05426.x
   Poewe W, 1999, NEUROLOGY, V52, pS2
   Potter GG, 2007, NEUROLOGIST, V13, P105, DOI 10.1097/01.nrl.0000252947.15389.a9
   Poynter B, 2009, PSYCHOSOMATICS, V50, P563, DOI 10.1176/appi.psy.50.6.563
   Qin LY, 2007, GLIA, V55, P453, DOI 10.1002/glia.20467
   Ramírez G, 2008, J ALZHEIMERS DIS, V15, P45
   Rashmi R, 2009, CLIN EXP DERMATOL, V34, P658, DOI 10.1111/j.1365-2230.2009.03410.x
   Rocha-Pereira P, 2004, BRIT J DERMATOL, V150, P917, DOI 10.1111/j.1365-2133.2004.05984.x
   Rocha-Pereira P, 2004, BRIT J DERMATOL, V150, P232, DOI 10.1111/j.1365-2133.2004.05801.x
   Rogers J, 2007, INT REV NEUROBIOL, V82, P235, DOI 10.1016/S0074-7742(07)82012-5
   Rossi-George A, 2005, J NEUROSCI, V25, P5314, DOI 10.1523/JNEUROSCI.0687-05.2005
   Sabry A, 2006, CYTOKINE, V35, P148, DOI 10.1016/j.cyto.2006.07.023
   Sawchenko PE, 2000, PROG BRAIN RES, V122, P61
   Schmitt J, 2010, J EUR ACAD DERMATOL, V24, P885, DOI 10.1111/j.1468-3083.2009.03537.x
   Schnydrig S, 2007, NEUROSCI LETT, V429, P69, DOI 10.1016/j.neulet.2007.09.067
   Shaker SB, 2008, CLIN RESPIR J, V2, P17, DOI 10.1111/j.1752-699X.2007.00032.x
   SHINTANI F, 1995, MOL NEUROBIOL, V10, P47, DOI 10.1007/BF02740837
   SHINTANI F, 1995, J NEUROSCI, V15, P1961, DOI 10.1523/JNEUROSCI.15-03-01961.1995
   Shizuya K, 1997, LIFE SCI, V61, pPL135, DOI 10.1016/S0024-3205(97)00608-5
   Sivonová M, 2004, STRESS, V7, P183, DOI 10.1080/10253890400012685
   Skapinakis P, 2004, PSYCHOSOM MED, V66, P330, DOI 10.1097/01.psy.0000124757.10167.b1
   Skapinakis P, 2003, AM J PSYCHIAT, V160, P785, DOI 10.1176/appi.ajp.160.4.785
   SONG C, 2010, PROG NEUROPSYCHOPHAR
   Sosnovskii A. S., 1992, Byulleten' Eksperimental'noi Biologii i Meditsiny, V113, P486
   Spiller RC, 2009, DIGEST DIS, V27, P48, DOI 10.1159/000268121
   Steffens DC, 1997, BIOL PSYCHIAT, V41, P851, DOI 10.1016/S0006-3223(96)00247-8
   Stockley RA, 2009, CURR MED RES OPIN, V25, P1235, DOI [10.1185/03007990902868971, 10.1185/03007990902868971 ]
   Stoll G, 1998, PROG NEUROBIOL, V56, P149, DOI 10.1016/S0301-0082(98)00034-3
   Sugama Shuei, 2009, Inflammation & Allergy Drug Targets, V8, P277
   Syrenicz A, 2006, NEUROENDOCRINOL LETT, V27, P453
   Tai YF, 2007, BRAIN, V130, P1759, DOI 10.1093/brain/awm044
   Takaki Atsushi, 1994, Neuroimmunomodulation, V1, P335, DOI 10.1159/000097185
   Tharwani Haresh M, 2007, Curr Psychiatry Rep, V9, P225, DOI 10.1007/s11920-007-0023-9
   Thiel A, 2010, J NUCL MED, V51, P1404, DOI 10.2967/jnumed.110.076612
   Town T, 2005, J NEUROINFLAMM, V2, DOI 10.1186/1742-2094-2-24
   Tsui H, 2007, TRENDS MOL MED, V13, P405, DOI 10.1016/j.molmed.2007.07.006
   Turrin NP, 2004, EXP BIOL MED, V229, P996, DOI 10.1177/153537020422901003
   Unützer J, 2009, J AM GERIATR SOC, V57, P506, DOI 10.1111/j.1532-5415.2008.02134.x
   Valderas JM, 2009, ANN FAM MED, V7, P357, DOI 10.1370/afm.983
   van den Bemt L, 2009, CHEST, V135, P108, DOI 10.1378/chest.08-0965
   van der Merwe MT, 2007, INT J OBESITY, V31, pS14, DOI 10.1038/sj.ijo.0803731
   Van Dyke K, 2010, ANN NY ACAD SCI, V1203, P138, DOI 10.1111/j.1749-6632.2010.05563.x
   van Manen JG, 2002, THORAX, V57, P412, DOI 10.1136/thorax.57.5.412
   Vanhala M, 2009, ACTA PSYCHIAT SCAND, V119, P137, DOI 10.1111/j.1600-0447.2008.01283.x
   Vas A, 2008, J NEUROL SCI, V264, P9, DOI 10.1016/j.jns.2007.07.018
   Viinamäki H, 2009, ACTA PSYCHIAT SCAND, V120, P23, DOI 10.1111/j.1600-0447.2008.01333.x
   Visser PJ, 2000, J AM GERIATR SOC, V48, P479, DOI 10.1111/j.1532-5415.2000.tb04992.x
   Vukic V, 2009, NEUROBIOL DIS, V34, P95, DOI 10.1016/j.nbd.2008.12.007
   Waheed Abdul, 2006, JPMA Journal of the Pakistan Medical Association, V56, P243
   Wang GD, 2010, ARTHRITIS RHEUM-US, V62, P2064, DOI 10.1002/art.27442
   WEKKING EM, 1993, PSYCHOSOM MED, V55, P219, DOI 10.1097/00006842-199303000-00011
   Wichers MC, 2005, MOL PSYCHIATR, V10, P538, DOI 10.1038/sj.mp.4001600
   Widner B, 1999, ADV EXP MED BIOL, V467, P571
   Widner B, 2000, IMMUNOBIOLOGY, V201, P621, DOI 10.1016/S0171-2985(00)80079-0
   Wilken JA, 2007, NEUROLOGIST, V13, P343, DOI 10.1097/NRL.0b013e31806dc2e8
   Wolfe F, 2010, J RHEUMATOL, V37, P305, DOI 10.3899/jrheum.090781
   Xu WN, 2008, AM J RESP CRIT CARE, V178, P913, DOI 10.1164/rccm.200804-619OC
   Yohannes Abebaw Mengistu, 2005, Br J Community Nurs, V10, P42
   Zunszain P.A., 2010, Prog Neuropsychopharmacol Biol Psychiatry
NR 200
TC 279
Z9 298
U1 1
U2 78
PU MAGHIRA & MAAS PUBLICATIONS
PI MUNSBACH
PA MAGHIRA & MAAS S A R L, 6C, RUE GABRIEL LIPPMANN, L-5365 MUNSBACH,
   LUXEMBOURG
SN 0172-780X
J9 NEUROENDOCRINOL LETT
JI Neuroendocrinol. Lett.
PY 2011
VL 32
IS 1
BP 7
EP 24
PG 18
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 746TX
UT WOS:000289271700003
PM 21407167
DA 2025-06-11
ER

PT J
AU Melamed, S
   Shirom, A
   Toker, S
   Berliner, S
   Shapira, I
AF Melamed, S
   Shirom, A
   Toker, S
   Berliner, S
   Shapira, I
TI Association of fear of terror with low-grade inflammation among
   apparently healthy employed adults
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE terror; stress; inflammation; depression; C-reactive protein
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE;
   SOCIOECONOMIC-STATUS; METABOLIC SYNDROME; RISK-FACTORS; STRESS;
   INTERLEUKIN-6; MARKERS; CYTOKINES
AB Objective: Based on evidence that psychological stress may induce a chronic inflammatory process, we hypothesized that the stress caused by chronic fear of terror may be associated with low-grade inflammation. This hypothesis was examined in employed men and women with the presence of low-grade inflammation measured by high sensitivity C-reactive protein (CRP). Methods: Apparently healthy employed adults (N = 1153) undergoing periodic health check-ups in a tertiary hospital in Israel completed a questionnaire. Fear of terror (scored 1-5) was assessed by three items measuring the extent to which respondents have deep concern for personal safety, elevated tension in crowded places, and fear of terror strikes causing harm to one's self or one's family members. The main outcome measure was the presence or absence of an elevated CRP level (>3.0 mg/L). Results: Women scored significantly higher on fear of terror compared with men (M = 2.16 vs. M = 1.68, respectively; p < .0001). Most of the study participants who scored high (4 or 5) on fear of terror, reported having experienced this feeling for 1 year or more. In women only, there was a positive association between fear of terror and risk of elevated CRP level (adjusted OR = 1.7, 95% CI 1.2-2.4) in a multivariate model adjusting for generalized anxiety, depressive symptoms, and potentially confounding demographic and biomedical variables. Conclusions: Chronic fear of terror in women, but not in men, is associated with elevated CRP levels, which suggests the presence of low-grade inflammation and a potential risk of cardiovascular disease.
C1 Natl Inst Occupat & Environm Hlth, Dept Occupat Hlth Psychol, IL-43100 Raanana, Israel.
   Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Inst Special Med Examiations,MALRAM, IL-69978 Tel Aviv, Israel.
   Tel Aviv Univ, Sackler Fac Med, Dept Med D, IL-69978 Tel Aviv, Israel.
   Tel Aviv Univ, Fac Management, IL-69978 Tel Aviv, Israel.
   Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv Sourasky
   Medical Center; Tel Aviv University; Sackler Faculty of Medicine; Tel
   Aviv University; Tel Aviv University; Sackler Faculty of Medicine
RP Natl Inst Occupat & Environm Hlth, Dept Occupat Hlth Psychol, POB 3, IL-43100 Raanana, Israel.
EM melameds@ioh.org.il
RI Toker, Sharon/P-5428-2015
OI Toker, Sharon/0000-0001-7621-6607
CR [Anonymous], 1999, DIAGN STAT MAN MENT
   Bermudez EA, 2002, ARTERIOSCL THROM VAS, V22, P1668, DOI 10.1161/01.ATV.0000029781.31325.66
   Black PH, 2003, BRAIN BEHAV IMMUN, V17, P350, DOI 10.1016/S0889-1591(03)00048-5
   Black PH, 2002, BRAIN BEHAV IMMUN, V16, P622, DOI 10.1016/S0889-1591(02)00021-1
   Black PH, 2002, J PSYCHOSOM RES, V52, P1, DOI 10.1016/S0022-3999(01)00302-6
   Blake GJ, 2001, CIRC RES, V89, P763, DOI 10.1161/hh2101.099270
   Bleich A, 2003, JAMA-J AM MED ASSOC, V290, P612, DOI 10.1001/jama.290.5.612
   Butler AS, 2003, PREPARING PSYCHOL CO
   Danenberg HD, 2003, CIRCULATION, V108, P512, DOI 10.1161/01.CIR.0000085568.13915.1E
   Danesh J, 2000, BMJ-BRIT MED J, V321, P199, DOI 10.1136/bmj.321.7255.199
   Danner M, 2003, PSYCHOSOM MED, V65, P347, DOI 10.1097/01.PSY.0000041542.29808.01
   DASILVA JAP, 1992, BAILLIERE CLIN RHEUM, V6, P193, DOI 10.1016/S0950-3579(05)80344-9
   de Maat M P, 2001, Ital Heart J, V2, P189
   Everly G S Jr, 2000, Int J Emerg Ment Health, V2, P53
   Freeman DJ, 2002, DIABETES, V51, P1596, DOI 10.2337/diabetes.51.5.1596
   FRENCH JRP, 1982, MECH JOB STRESS STRA, P14
   Galea S, 2002, NEW ENGL J MED, V346, P982, DOI 10.1056/NEJMsa013404
   Gidron Y, 1999, J TRAUMA STRESS, V12, P185, DOI 10.1023/A:1024762819880
   Griselli M, 1999, J EXP MED, V190, P1733, DOI 10.1084/jem.190.12.1733
   Kobayashi S, 2003, ARTERIOSCL THROM VAS, V23, P1398, DOI 10.1161/01.ATV.0000081637.36475.BC
   Koenig W, 1999, CIRCULATION, V99, P237, DOI 10.1161/01.CIR.99.2.237
   KOENIG W, 2001, CARDIOL REV, V89, P763
   Kop WJ, 2003, BRAIN BEHAV IMMUN, V17, P233, DOI 10.1016/S0889-1591(03)00051-5
   Kreitler S, 2002, CLIN DERMATOL, V20, P413, DOI 10.1016/S0738-081X(02)00242-0
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Kuda Tomoharu, 2002, Jpn J Thorac Cardiovasc Surg, V50, P206
   Kuller LH, 1996, AM J EPIDEMIOL, V144, P537, DOI 10.1093/oxfordjournals.aje.a008963
   Ladwig KH, 2003, BRAIN BEHAV IMMUN, V17, P268, DOI 10.1016/S0889-1591(03)00056-4
   Lahita RG, 1997, INT J FERTIL WOMEN M, V42, P115
   Libby P, 2002, CIRCULATION, V105, P1135, DOI 10.1161/hc0902.104353
   Maier SF, 1998, PSYCHOL REV, V105, P83, DOI 10.1037/0033-295X.105.1.83
   Miller RJ, 2001, CYTOKINE, V13, P253, DOI 10.1006/cyto.2000.0825
   Nakamura M, 2003, PEDIATR SURG INT, V19, P194, DOI 10.1007/s00383-002-0917-x
   Norris FH, 2002, PSYCHIATRY, V65, P207, DOI 10.1521/psyc.65.3.207.20173
   Owen N, 2003, BRAIN BEHAV IMMUN, V17, P286, DOI 10.1016/S0889-1591(03)00058-8
   Papanicolaou DA, 1998, ANN INTERN MED, V128, P127, DOI 10.7326/0003-4819-128-2-199801150-00009
   Penninx BWJH, 2003, BIOL PSYCHIAT, V54, P566, DOI 10.1016/S0006-3223(02)01811-5
   Pepys MB, 2003, J CLIN INVEST, V111, P1805, DOI 10.1172/JCI200318921
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Reichenberg A, 2001, ARCH GEN PSYCHIAT, V58, P445, DOI 10.1001/archpsyc.58.5.445
   Riba Shoshana, 2002, Online J Issues Nurs, V7, P6
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   Ridker PM, 1998, CIRCULATION, V97, P425
   Ridker PM, 2003, CIRCULATION, V107, P363, DOI 10.1161/01.CIR.0000053730.47739.3C
   Ridker PM, 1998, CIRCULATION, V98, P731, DOI 10.1161/01.CIR.98.8.731
   Ridker PM, 1997, NEW ENGL J MED, V336, P973, DOI 10.1056/NEJM199704033361401
   Ridker PM, 2002, NEW ENGL J MED, V347, P1557, DOI 10.1056/NEJMoa021993
   Ridker PM, 2001, JAMA-J AM MED ASSOC, V285, P2481, DOI 10.1001/jama.285.19.2481
   Ridker PM, 2000, NEW ENGL J MED, V342, P836, DOI 10.1056/NEJM200003233421202
   Rifai N, 1999, CLIN CHEM, V45, P2136
   Rifai N, 2002, CURR OPIN LIPIDOL, V13, P383, DOI 10.1097/00041433-200208000-00005
   Rifai N, 2003, CLIN CHEM, V49, P666, DOI 10.1373/49.4.666
   ROGOWSKY O, IN PRESS BIOMARKERS
   Rohleder N, 2001, PSYCHOSOM MED, V63, P966, DOI 10.1097/00006842-200111000-00016
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Sattar N, 2003, CIRCULATION, V108, P414, DOI 10.1161/01.CIR.0000080897.52664.94
   Schlenger WE, 2002, JAMA-J AM MED ASSOC, V288, P581, DOI 10.1001/jama.288.5.581
   Schnorpfeil P, 2003, SOC SCI MED, V57, P647, DOI 10.1016/S0277-9536(02)00407-0
   Schuster MA, 2001, NEW ENGL J MED, V345, P1507, DOI 10.1056/NEJM200111153452024
   Silver RC, 2002, JAMA-J AM MED ASSOC, V288, P1235, DOI 10.1001/jama.288.10.1235
   SPITZER RL, 1999, JAMA-J AM MED ASSOC, V282, P1731
   Stephenson J, 2001, JAMA-J AM MED ASSOC, V286, P1823, DOI 10.1001/jama.286.15.1823
   Steptoe A, 2003, PSYCHOL MED, V33, P667, DOI 10.1017/S0033291702007250
   Steptoe A, 2002, BRAIN BEHAV IMMUN, V16, P774, DOI 10.1016/S0889-1591(02)00030-2
   Tracy RP, 1997, ARTERIOSCL THROM VAS, V17, P1121, DOI 10.1161/01.ATV.17.6.1121
   Wakefield JC, 2002, ARCH GEN PSYCHIAT, V59, P129, DOI 10.1001/archpsyc.59.2.129
   Weaver JD, 2002, NEUROLOGY, V59, P371, DOI 10.1212/WNL.59.3.371
   Wilder RL, 1998, ANN NY ACAD SCI, V840, P45, DOI 10.1111/j.1749-6632.1998.tb09547.x
   Wilson CJ, 2002, J AM GERIATR SOC, V50, P2041, DOI 10.1046/j.1532-5415.2002.50619.x
NR 69
TC 43
Z9 49
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JUL-AUG
PY 2004
VL 66
IS 4
BP 484
EP 491
DI 10.1097/01.psy.0000130963.52755.b9
PG 8
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 840KX
UT WOS:000222858600004
PM 15272092
DA 2025-06-11
ER

PT J
AU Fernández-Abascal, B
   Suárez-Pinilla, M
   Cobo-Corrales, C
   Crespo-Facorro, B
   Suárez-Pinilla, P
AF Fernandez-Abascal, Blanca
   Suarez-Pinilla, Marta
   Cobo-Corrales, Carlos
   Crespo-Facorro, Benedicto
   Suarez-Pinilla, Paula
TI Lifestyle intervention based on exercise and behavioural counselling and
   its effect on physical and psychological health in outpatients with
   schizophrenia spectrum disorders. An exploratory, pragmatic randomized
   clinical trial
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE Schizophrenia; Exercise; Physical activity; Metabolic syndrome; Clinical
   trial; Follow-up studies
ID SELF-DETERMINATION THEORY; INDUCED WEIGHT-GAIN; AEROBIC EXERCISE;
   METABOLIC ABNORMALITIES; BODY-COMPOSITION; SEX-DIFFERENCES;
   BLOOD-PRESSURE; IMPACT; INDIVIDUALS; RISK
AB Patients with Schizophrenia Spectrum Disorders (SSD) often lead unhealthy lifestyles. This pragmatic trial evaluated the effectiveness of a lifestyle intervention, consisting of a 12-week aerobic exercise program and behavioural counselling, in SSD outpatients with metabolic syndrome (MetS). It also aimed to assess persistence of potential effects in a 24-month long-term follow-up. Effectiveness was measured in terms of a wide range of outcomes involving physical and psychological health, quality of life, physical activity and changes in motivation to exercise within the context of the self-determination theory. Our primary outcome was waist circumference change. Thirty-three out of 48 participants completed the study. No differences between groups were found in terms of BMI change or other metabolic parameters. However, the active group (AG) showed improvement regarding waist circumference, negative symptomatology and identified motivation to exercise during the study and follow-up. The AG exhibited changes toward a more active pattern of activity after intervention. Moreover, belonging to the AG was a significant predictor for achieving any degree of clinical improvement after 24-month follow-up. Combined interventions of exercise and behavioural counselling in SSD patients with MetS should be considered as an essential part of the integral treatment in the context of mental health services.
C1 [Fernandez-Abascal, Blanca; Suarez-Pinilla, Paula] Univ Cantabria, Univ Hosp Marques Valdecilla, Dept Psychiat, IDIVAL,Med Sch, Santander 39011, Spain.
   [Cobo-Corrales, Carlos] Univ Cantabria, Sch Educ, Santander 39005, Spain.
   [Crespo-Facorro, Benedicto] Univ Hosp Virgen Rocio IBiS, Sch Med, Dept Psychiat, Seville 41013, Spain.
   [Crespo-Facorro, Benedicto; Suarez-Pinilla, Paula] Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid 28029, Spain.
   [Suarez-Pinilla, Marta] Univ Politecn Madrid UPM, Ctr Biomed Technol, Lab Clin Neurosci, Madrid 28223, Spain.
   [Suarez-Pinilla, Paula] Hosp Univ Marques Valdecilla, Dept Psychiat, Avda Valdecilla S-N, Santander 39008, Spain.
C3 Hospital Universitario Marques de Valdecilla (HUMV); Universidad de
   Cantabria; Universidad de Cantabria; Virgen del Rocio University
   Hospital; Consejo Superior de Investigaciones Cientificas (CSIC);
   University of Sevilla; CSIC-JA-USE - Instituto de Biomedicina de Sevilla
   (IBIS); CIBER - Centro de Investigacion Biomedica en Red; CIBERSAM;
   Instituto de Salud Carlos III; Universidad Politecnica de Madrid;
   Hospital Universitario Marques de Valdecilla (HUMV)
RP Suárez-Pinilla, P (corresponding author), Hosp Univ Marques Valdecilla, Dept Psychiat, Avda Valdecilla S-N, Santander 39008, Spain.
RI Suárez Pinilla, Marta/JHU-6581-2023; Crespo-Facorro,
   BENEDICTO/AAY-2238-2021
OI Crespo-Facorro, Benedicto/0000-0003-0033-7132; Suarez-Pinilla,
   Marta/0000-0002-6437-3741
CR Allen NB, 2006, AUST NZ J PSYCHIAT, V40, P285, DOI 10.1080/j.1440-1614.2006.01794.x
   Allison DB, 1999, AM J PSYCHIAT, V156, P1686
   Martínez-González MA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043134
   Ashdown-Franks G, 2020, SPORTS MED, V50, P151, DOI 10.1007/s40279-019-01187-6
   Bazett-Jones DM, 2021, FRONT SPORTS ACT LIV, V3, DOI 10.3389/fspor.2021.696264
   Bonfioli E, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-78
   Brown C, 2014, SCHIZOPHR RES, V159, P421, DOI 10.1016/j.schres.2014.09.018
   Caemmerer J, 2012, SCHIZOPHR RES, V140, P159, DOI 10.1016/j.schres.2012.03.017
   Casey DE, 2004, J CLIN PSYCHIAT, V65, P4
   Cegalis J., 1991, Vigil: Software for the Assessment of Attention
   Chuang HH, 2012, BIOFACTORS, V38, P284, DOI 10.1002/biof.1027
   Dauwan M, 2016, SCHIZOPHRENIA BULL, V42, P588, DOI 10.1093/schbul/sbv164
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   Deci EL, 2008, CAN PSYCHOL, V49, P182, DOI 10.1037/a0012801
   Deci EL, 2000, PSYCHOL INQ, V11, P227, DOI 10.1207/S15327965PLI1104_01
   Dhand N. K., 2014, STATULATOR ONLINE ST
   Faulkner G, 2006, SCHIZOPHR RES, V82, P225, DOI 10.1016/j.schres.2005.10.020
   Fernández-Abascal B, 2021, NEUROSCI BIOBEHAV R, V125, P535, DOI 10.1016/j.neubiorev.2021.01.005
   FRANZOI SL, 1984, J PERS ASSESS, V48, P173, DOI 10.1207/s15327752jpa4802_12
   Godin G., 2011, HLTH FITNESS J CANAD, V4, P18, DOI [DOI 10.14288/HFJC.V4I1.82, 10.14288/hfjc.v4i1.82, 10.1037/t31334-000]
   Goodman JM, 2011, APPL PHYSIOL NUTR ME, V36, pS14, DOI [10.1139/h11-048, 10.1139/H11-048]
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Guy W., 1976, ECDEU Assessment Manual for Psychopharmacology, Revised. US Department of Health, Education, and Welfare Publication (ADM), P76
   Halabchi F, 2017, BMC NEUROL, V17, DOI 10.1186/s12883-017-0960-9
   Harris EC, 1998, BRIT J PSYCHIAT, V173, P11, DOI 10.1192/bjp.173.1.11
   Holt RIG, 2019, BRIT J PSYCHIAT, V214, P63, DOI 10.1192/bjp.2018.167
   Houle SKD, 2014, CURR OPIN CARDIOL, V29, P344, DOI 10.1097/HCO.0000000000000071
   IBM Corporation, 2021, IBM SPSS Statistics for Windows. version 28.0
   Janssen I, 2004, AM J CLIN NUTR, V79, P379
   Jean-Baptiste M, 2007, SCHIZOPHR RES, V96, P198, DOI 10.1016/j.schres.2007.05.022
   Jorquera M., 2005, Rev. Psicopatologia y Psicol. Clinica
   Kang RY, 2016, PSYCHOPATHOLOGY, V49, P345, DOI 10.1159/000448195
   KAY SR, 1988, PSYCHIAT RES, V23, P99, DOI 10.1016/0165-1781(88)90038-8
   Khalafi M, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1183765
   Khazaeinia T, 2000, J PHARM PHARM SCI, V3, P292
   Kimhy D, 2015, SCHIZOPHRENIA BULL, V41, P859, DOI 10.1093/schbul/sbv022
   Legault L., 2016, ENCY PERSONALITY IND, DOI [DOI 10.1007/978-3-319-28099-8_1139-1, 10.1007/978-3-319-28099-8_1139-1]
   Lemieux S, 1996, AM J CLIN NUTR, V64, P685, DOI 10.1093/ajcn/64.5.685
   Leucht S, 2013, LANCET, V382, P951, DOI 10.1016/S0140-6736(13)60733-3
   Markland D, 2004, J SPORT EXERCISE PSY, V26, P191, DOI 10.1123/jsep.26.2.191
   McKibbin CL, 2006, SCHIZOPHR RES, V86, P36, DOI 10.1016/j.schres.2006.05.010
   Melamed Y, 2008, PSYCHIATR REHABIL J, V31, P194, DOI 10.2975/31.3.2008.194.200
   Methapatara W, 2011, PSYCHIAT CLIN NEUROS, V65, P374, DOI 10.1111/j.1440-1819.2011.02225.x
   National Collaborating Center for Mental Health, 2014, Psychosis and schizophrenia in adults: Treatment and management
   Newcomer JW, 2007, JAMA-J AM MED ASSOC, V298, P1794, DOI 10.1001/jama.298.15.1794
   Oertel-Knöchel V, 2014, EUR ARCH PSY CLIN N, V264, P589, DOI 10.1007/s00406-014-0485-9
   Ohi K, 2019, EUR ARCH PSY CLIN N, V269, P517, DOI 10.1007/s00406-018-0903-5
   Pajonk FG, 2010, ARCH GEN PSYCHIAT, V67, P133, DOI 10.1001/archgenpsychiatry.2009.193
   Pearson D, 2013, Weight Manag, P233, DOI [10.1002/9781118702758.app9, DOI 10.1002/9781118702758.APP9]
   Poulin MJ, 2007, AUST NZ J PSYCHIAT, V41, P980, DOI 10.1080/00048670701689428
   Ratliff' JC, 2012, COMPR PSYCHIAT, V53, P1028, DOI 10.1016/j.comppsych.2012.02.003
   Reitan R. M., 1985, The Halstead-Reitan neuropsychological test battery: Theory and clinical interpretation
   Rosa Adriane R, 2007, Clin Pract Epidemiol Ment Health, V3, P5, DOI 10.1186/1745-0179-3-5
   Ryan RM, 2000, AM PSYCHOL, V55, P68, DOI 10.1037/0003-066X.55.1.68
   Sabe M, 2020, GEN HOSP PSYCHIAT, V62, P13, DOI 10.1016/j.genhosppsych.2019.11.002
   Sabe M, 2019, SCHIZOPHR RES, V212, P15, DOI 10.1016/j.schres.2019.07.030
   Sheehan DV, 1998, J CLIN PSYCHIAT, V59, P22, DOI 10.4088/JCP.09m05305whi
   Skene SS, 2010, STAT MED, V29, P2825, DOI 10.1002/sim.4073
   Stanton R, 2014, CURR SPORT MED REP, V13, P260, DOI 10.1249/JSR.0000000000000069
   Theodorakopoulos C, 2017, NUTR RES, V43, P3, DOI 10.1016/j.nutres.2017.05.002
   Vancampfort D, 2019, WORLD PSYCHIATRY, V18, P53, DOI 10.1002/wps.20614
   Vancampfort D, 2015, COMPR PSYCHIAT, V56, P128, DOI 10.1016/j.comppsych.2014.10.007
   Vancampfort D, 2013, PSYCHIAT RES, V210, P812, DOI 10.1016/j.psychres.2013.10.004
   Vancampfort D, 2013, GEN HOSP PSYCHIAT, V35, P653, DOI 10.1016/j.genhosppsych.2013.07.004
   Vancampfort D, 2012, PSYCHIAT RES, V200, P73, DOI 10.1016/j.psychres.2012.03.046
   Vansteenkiste M, 2010, ADV MOTIV A, V16, P105, DOI 10.1108/S0749-7423(2010)000016A007
   Viljoen Margaretha, 2020, Aust J Gen Pract, V49, P803, DOI 10.31128/AJGP-04-20-5384
   Vogel JS, 2019, PSYCHIAT RES, V279, P295, DOI 10.1016/j.psychres.2019.03.012
   Ware JE., 2000, The SF-36 Health Survey: Manual and Interpretation Guide
   Wechsler D., 2008, Wechsler Adult Intelligence ScaleFourth Edition Administration and Scoring Manual, Vfourth
   Whelton SP, 2002, ANN INTERN MED, V136, P493, DOI 10.7326/0003-4819-136-7-200204020-00006
   Williams J, 2016, TRIALS, V17, DOI 10.1186/s13063-016-1660-2
   Wilsgaard T, 2000, ARCH INTERN MED, V160, P2847, DOI 10.1001/archinte.160.18.2847
   WINCH RF, 1965, SOC FORCES, V44, P255
   Worswick E, 2018, PSYCHOPATHOLOGY, V51, P1, DOI 10.1159/000484414
   Wu MK, 2007, PSYCHIAT SERV, V58, P544, DOI 10.1176/appi.ps.58.4.544
   Zwarenstein M, 2008, BMJ-BRIT MED J, V337, DOI 10.1136/bmj.a2390
NR 78
TC 1
Z9 1
U1 1
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD NOV
PY 2023
VL 261
BP 256
EP 268
DI 10.1016/j.schres.2023.09.036
EA OCT 2023
PG 13
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FZ1Z2
UT WOS:001149598200001
PM 37857138
DA 2025-06-11
ER

PT J
AU Guyot, E
   Baudry, J
   Hercberg, S
   Galan, P
   Kesse-Guyot, E
   Péneau, S
AF Guyot, Erika
   Baudry, Julia
   Hercberg, Serge
   Galan, Pilar
   Kesse-Guyot, Emmanuelle
   Peneau, Sandrine
TI Mindfulness Is Associated with the Metabolic Syndrome among Individuals
   with a Depressive Symptomatology
SO NUTRIENTS
LA English
DT Article
DE mindfulness; metabolic syndrome x; risk factors; depression;
   epidemiology
ID DISPOSITIONAL MINDFULNESS; EATING-DISORDERS; HEALTHY WOMEN; LIFE-EVENTS;
   5 FACETS; INTERVENTIONS; RISK; QUESTIONNAIRE; STRESS; NUTRITION
AB The Metabolic Syndrome (MetS) is a major public health burden. Dispositional mindfulness has recently been associated with eating disorders, being overweight, and could therefore be associated with the MetS. We aimed to examine in a cross-sectional design the relationship between mindfulness, the MetS, and its risk factors in a large sample of the adult general population and the influence of depressive symptomatology on this association. Adults participating in the NutriNet-Sante study who had completed the Five Facets Mindfulness Questionnaire and attended a clinical and biological examination were available for inclusion. Multivariable logistic regression models adjusted for socio-demographic and lifestyle factors were performed. A total of 17,490 individuals were included. Among individuals with a depressive symptomatology, those with higher mindfulness were less likely to have a MetS (OR: 0.73, 95% CI: 0.57-0.93), a high waist circumference, a low HDL-cholesterol level and an elevated fasting blood glucose level (all p<0.05). In those without depressive symptomatology, individuals with higher mindfulness were less likely to have a high waist circumference (p<0.01). In conclusion, higher mindfulness was associated with lower odds of developing a MetS only among individuals with a depressive symptomatology.
C1 [Guyot, Erika; Baudry, Julia; Hercberg, Serge; Galan, Pilar; Kesse-Guyot, Emmanuelle; Peneau, Sandrine] Paris 13 Univ, Ctr Res Epidemiol & Stat, Nutr Epidemiol Res Team EREN,COMUE, Sorbonne Paris Cite,INSERM,U1153,Inra,U1125,CNAM, F-93017 Bobigny, France.
   [Hercberg, Serge] Paris 13 Univ, Sorbonne Paris Cite, Surveillance & Nutr Epidemiol Res Unit, Sante Publ France,COMUE, F-93017 Bobigny, France.
   [Hercberg, Serge] Avicenne Hosp, Publ Hlth Dept, F-93017 Bobigny, France.
C3 INRAE; Institut National de la Sante et de la Recherche Medicale
   (Inserm); heSam Universite; Conservatoire National Arts & Metiers
   (CNAM); Universite Paris Cite; Sante publique France; Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Avicenne - APHP
RP Guyot, E (corresponding author), Paris 13 Univ, Ctr Res Epidemiol & Stat, Nutr Epidemiol Res Team EREN,COMUE, Sorbonne Paris Cite,INSERM,U1153,Inra,U1125,CNAM, F-93017 Bobigny, France.
EM e.guyot@eren.smbh.univ-paris13.fr; j.baudry@uren.smbh.univ-paris13.fr;
   s.hercberg@eren.smbh.univ-paris13.fr; p.galan@eren.smbh.univ-paris13.fr;
   e.kesse@eren.smbh.univ-paris13.fr; s.peneau@eren.smbh.univ-paris13.fr
RI Peneau, Sandrine/F-2701-2017; Pilar, Galan/F-2908-2017; Serge,
   Hercberg/F-3038-2017; Guyot, Erika/AAC-1624-2020; Kesse-Guyot,
   Emmanuelle/F-2692-2017; Guyot, Erika/M-7236-2017
OI Kesse-Guyot, Emmanuelle/0000-0002-9715-3534; Guyot,
   Erika/0000-0002-3715-1852
FU French Ministry of Health (DGS); Sante publique France (SpF); French
   National Institute for Health and Medical Research (INSERM); French
   National Institute for Agricultural Research (INRA); National
   Conservatory for Arts and Crafts (CNAM); Medical Research Foundation
   (FRM); University of Paris 13
FX The authors thank Younes Esseddik, Thi Duong Van, Frederic Coffinieres,
   Mac Rakotondrazafy, Regis Gatibelza and Paul Flanzy (computer
   scientists); and Nathalie Arnault, Veronique Gourlet, Fabien Szabo,
   Julien Allegre, Anouar Nechba and Laurent Bourhis
   (data-manager/biostatisticians) for their technical contribution to the
   NutriNet-Sante study. The authors thank all the volunteers of the
   NutriNet-Sante cohort. The NutriNet-Sante Study is supported by the
   French Ministry of Health (DGS), Sante publique France (SpF), the French
   National Institute for Health and Medical Research (INSERM), the French
   National Institute for Agricultural Research (INRA), the National
   Conservatory for Arts and Crafts (CNAM), the Medical Research Foundation
   (FRM) and the University of Paris 13.
CR Abramowitz JS, 2001, CLIN PSYCHOL REV, V21, P683, DOI 10.1016/S0272-7358(00)00057-X
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Anderson JG, 2011, J NUTR METAB, V2011, DOI 10.1155/2011/276419
   Anicha CL, 2012, J PERS, V80, P255, DOI 10.1111/j.1467-6494.2011.00722.x
   [Anonymous], 2011, Waist Circumference and Waist-Hip Ratio: Report of a WHO Expert Consultation
   [Anonymous], 2009, Global health risks: mortality and burden of disease attributable to selected major risks
   Baer RA, 2006, ASSESSMENT, V13, P27, DOI 10.1177/1073191105283504
   Bajaj B, 2016, PERS INDIV DIFFER, V96, P127, DOI 10.1016/j.paid.2016.02.085
   Beshara M, 2013, APPETITE, V67, P25, DOI 10.1016/j.appet.2013.03.012
   Black AE, 2000, INT J OBESITY, V24, P1119, DOI 10.1038/sj.ijo.0801376
   Bohlmeijer E, 2011, ASSESSMENT, V18, P308, DOI 10.1177/1073191111408231
   Bowen S, 2009, SUBST ABUS, V30, P295, DOI 10.1080/08897070903250084
   Brown DB, 2015, MINDFULNESS, V6, P1021, DOI 10.1007/s12671-014-0349-4
   Camilleri GM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0127447
   Caspi A, 2003, SCIENCE, V301, P386, DOI 10.1126/science.1083968
   Chen CC, 2008, METABOLISM, V57, P544, DOI 10.1016/j.metabol.2007.11.018
   Chiesa A, 2011, J ALTERN COMPLEM MED, V17, P83, DOI 10.1089/acm.2009.0546
   Daskalopoulou M, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0153838
   Daubenmier J, 2016, OBESITY, V24, P794, DOI 10.1002/oby.21396
   Donofry SD, 2016, NEUROSCI BIOBEHAV R, V68, P911, DOI 10.1016/j.neubiorev.2016.07.011
   Edwardson CL, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034916
   Esmaillzadeh A, 2006, AM J CLIN NUTR, V84, P1489, DOI 10.1093/ajcn/84.6.1489
   Etude Nutrinet-Sante, 2013, TABL COMP AL ET NUTR
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   Gilbert D., 2010, MINDFULNESS, V1, P227, DOI DOI 10.1007/S12671-010-0032-3
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Goodall K, 2012, PERS INDIV DIFFER, V52, P622, DOI 10.1016/j.paid.2011.12.008
   Hagströmer M, 2006, PUBLIC HEALTH NUTR, V9, P755, DOI 10.1079/PHN2005898
   Heeren A, 2011, EUR REV APPL PSYCHOL, V61, P147, DOI 10.1016/j.erap.2011.02.001
   Hercberg S, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-242
   Hudson JI, 2010, AM J CLIN NUTR, V91, P1568, DOI 10.3945/ajcn.2010.29203
   Johnston L, 1999, INT J EAT DISORDER, V26, P21, DOI 10.1002/(SICI)1098-108X(199907)26:1<21::AID-EAT3>3.0.CO;2-7
   Jordan CH, 2014, PERS INDIV DIFFER, V68, P107, DOI 10.1016/j.paid.2014.04.013
   Kabat-Zinn J, 2003, CLIN PSYCHOL-SCI PR, V10, P144, DOI 10.1093/clipsy/bpg016
   Lassale C, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076349
   Liu Herong, 2015, Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, V33, P88
   Loucks EB, 2016, AM J HEALTH BEHAV, V40, P258, DOI 10.5993/AJHB.40.2.11
   Loucks EB, 2015, INT J BEHAV MED, V22, P540, DOI 10.1007/s12529-014-9448-9
   Lutsey PL, 2008, CIRCULATION, V117, P754, DOI 10.1161/CIRCULATIONAHA.107.716159
   Malik VS, 2010, DIABETES CARE, V33, P2477, DOI 10.2337/dc10-1079
   Marchiori D, 2014, APPETITE, V75, P40, DOI 10.1016/j.appet.2013.12.009
   Momeni J, 2016, J AM SOC HYPERTENS, V10, P763, DOI 10.1016/j.jash.2016.07.007
   Mommersteeg PMC, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-714
   Moullec N. le, 1996, Cahiers de Nutrition et de Dietetique, V31, P158
   Murray CJL, 2012, LANCET, V380, P2197, DOI 10.1016/S0140-6736(12)61729-2
   Neufcourt L, 2015, NUTR METAB CARDIOVAS, V25, P988, DOI 10.1016/j.numecd.2015.09.002
   O'Reilly GA, 2014, OBES REV, V15, P453, DOI 10.1111/obr.12156
   Park SJ, 2016, J AFFECT DISORDERS, V205, P393, DOI 10.1016/j.jad.2016.08.022
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Shennan C, 2011, PSYCHO-ONCOLOGY, V20, P681, DOI 10.1002/pon.1819
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   STROBER M, 1984, INT J EAT DISORDER, V3, P3, DOI 10.1002/1098-108X(198424)3:2<3::AID-EAT2260030203>3.0.CO;2-6
   Sutin AR, 2010, AGE, V32, P513, DOI 10.1007/s11357-010-9153-9
   Troop NA, 1997, BRIT J MED PSYCHOL, V70, P373, DOI 10.1111/j.2044-8341.1997.tb01913.x
   Vernay M, 2013, INT J PUBLIC HEALTH, V58, P855, DOI 10.1007/s00038-013-0501-2
   Williams JMG, 2008, J AFFECT DISORDERS, V107, P275, DOI 10.1016/j.jad.2007.08.022
   Wingenfeld K, 2017, PSYCHONEUROENDOCRINO, V80, P122, DOI 10.1016/j.psyneuen.2017.03.014
   Younge JO, 2015, PSYCHOSOM MED, V77, P775, DOI 10.1097/PSY.0000000000000213
NR 58
TC 3
Z9 3
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2018
VL 10
IS 2
AR 232
DI 10.3390/nu10020232
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA FZ4CY
UT WOS:000427540000122
PM 29462979
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Gallegos-Gonzalez, G
   Pineda-García, G
   Serrano-Medina, A
   Martinez, AL
   Ochoa-Ruiz, E
AF Gallegos-Gonzalez, Guadalupe
   Pineda-Garcia, Gisela
   Serrano-Medina, Aracely
   Laura Martinez, Ana
   Ochoa-Ruiz, Estefania
TI Association between Stress and Metabolic Syndrome and its Mediating
   Factors in University Students
SO AMERICAN JOURNAL OF HEALTH BEHAVIOR
LA English
DT Article
DE perceived stress; sleep quality; metabolic syndrome; eating habits;
   university students
ID NIGHT-EATING SYNDROME; SLEEP QUALITY INDEX; PSYCHOMETRIC PROPERTIES;
   PREVALENCE; OBESITY; TIME
AB Objectives: In this study, we evaluated the association between perceived stress and indicators of metabolic syndrome and how this association is mediated by sleep problems, unhealthy eating habits, and night eating syndrome, in addition to serum levels of ghrelin and cortisol in university students. Methods: We recruited 192 students from a public university in Mexico. Weight, height, waist circumference and blood pressure were taken in accordance with standard protocols. Validated questionnaires were used to assess perceived stress, sleep quality and eating habits. Fasting blood samples were taken to measure ghrelin, cortisol, triglycerides, glucose and HDL-C. Results: Path Analysis indicated direct positive effects of stress over PSQI (0 = 0.341) and NES (0 = 0.443); PSQI over NES (0 = 0.233) and NES over glucose (0 = 0.170), triglycerides over LDL-C (0 = 0.215), waist circumference over SBP (0 = 0.259). Likewise, standardized negative regression weights of PSQI over Diet Quality Index (0 =-0.239) and ghrelin concentrations (0 =-0.132), ghrelin over Diet Quality Index (0 =-0.188) and waist circumference (0 =-0.147). Diet Quality Index over triglycerides (0 =-0.184); sleep duration over systolic blood pressure (0 =-0.242); waist circumference over HDL-C (0 =-0.256). Conclusion: Psychological stress leads to increased indicators of MetS via decreased sleep quality, inadequate eating habits and eating behavior in university students.
C1 [Gallegos-Gonzalez, Guadalupe; Pineda-Garcia, Gisela; Serrano-Medina, Aracely; Laura Martinez, Ana; Ochoa-Ruiz, Estefania] Autonomous Univ Baja California, Fa Med & Psychol, Tijuana, BC, Mexico.
C3 Universidad Autonoma de Baja California
RP Ochoa-Ruiz, E (corresponding author), Autonomous Univ Baja California, Fa Med & Psychol, Tijuana, BC, Mexico.
EM estefania.ochoa@uabc.edu.mx
RI Serrano-Medina, Aracely/AAV-2741-2021
FU SEP-PRODEP [511-6/18-8833]
FX SEP-PRODEP, Grant No. 511-6/18-8833 funded this research. The funder had
   no role in the study design, data collection and analysis, decision to
   publish, or preparation of the manuscript. We are grateful to Dr.
   Gilberto Ochoa for providing helpful guidance.
CR Aguirre GA, 2016, J TRANSL MED, V14, DOI 10.1186/s12967-015-0762-z
   Al Massadi O, 2019, NEUROPHARMACOLOGY, V148, P131, DOI 10.1016/j.neuropharm.2019.01.001
   Allison KC, 2021, CURR BIOL, P1
   Allison Kelly C, 2008, Eat Behav, V9, P62, DOI 10.1016/j.eatbeh.2007.03.007
   Amaral AP, 2018, PSYCHIAT RES, V260, P331, DOI 10.1016/j.psychres.2017.11.072
   García-León MA, 2019, PHYSIOL BEHAV, V202, P87, DOI 10.1016/j.physbeh.2019.02.001
   Barquera S, 2020, SALUD PUBLICA MEXICO, V62, P682, DOI 10.21149/11630
   Blumfield ML, 2018, APPETITE, V120, P602, DOI 10.1016/j.appet.2017.10.022
   Brown University, 2004, DEP COMM HLTH
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1016/0165-1781(89)90047-4
   Chaudhary N, 2017, CTR DIS CONTROL PREV, V14, P1, DOI [10.1016/S0026-0576(13)70219-8, DOI 10.1016/S0026-0576(13)70219-8]
   Debeuf T, 2018, FRONT PSYCHOL, V9, DOI 10.3389/fpsyg.2018.02657
   Di Marzo V, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081956
   Epel E, 2004, ANN NY ACAD SCI, V1032, P208, DOI 10.1196/annals.1314.022
   Gao XL, 2021, NUTRIENTS, V13, DOI 10.3390/nu13072179
   Garbarino S, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0224259
   Garbarino S, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0144318
   Garcez A, 2017, HORM METAB RES, V49, P510, DOI 10.1055/s-0043-101822
   He JB, 2019, PSYCHOL HEALTH MED, V24, P68, DOI 10.1080/13548506.2018.1488081
   Hilger J, 2017, APPETITE, V109, P100, DOI 10.1016/j.appet.2016.11.016
   Hinz A, 2017, SLEEP MED, V30, P57, DOI 10.1016/j.sleep.2016.03.008
   Hirshkowitz M, 2015, SLEEP HEALTH, V1, P40, DOI 10.1016/j.sleh.2014.12.010
   Hooshmand F, 2018, J PEDIATR-US, V197, P134, DOI 10.1016/j.jpeds.2018.01.080
   Icaro J.S. Ribeiro., 2018, HLTH PROFESSIONS ED, V4, P70, DOI [10.1016/j.hpe.2017.03.002, DOI 10.1016/J.HPE.2017.03.002, 10.1016/J.HPE.2017.03.002]
   InternationalDiabetesFederation, 2019, DIABETES ATLAS, V9th
   Johnston CS, 2018, NUTR J, V17, DOI 10.1186/s12937-018-0399-x
   Joo G, 2017, EFFECT JOB STRESS ME, V7, P726, DOI [10.21215/kjfp.2017.7.5.726, DOI 10.21215/KJFP.2017.7.5.726]
   Jose Jesus Gazquez Linares, 2019, NIEVES FATIMA OROPES, P1
   Lee MK, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-59203-z
   Lopez-Minguez J, 2018, CLIN NUTR, V37, P1133, DOI 10.1016/j.clnu.2017.04.003
   Magnavita N, 2018, OCCUPATIONAL STRESS, P81
   Mayra S, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061427
   Mbugua SM, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4936-x
   McCuen-Wurst C, 2018, ANN NY ACAD SCI, V1411, P96, DOI 10.1111/nyas.13467
   NHLBI, 2021, NAT HEART LUNG BLOOD
   Nolan Paul B, 2017, Prev Med Rep, V7, P211, DOI 10.1016/j.pmedr.2017.07.004
   Remor E, 2006, SPAN J PSYCHOL, V9, P86, DOI 10.1017/S1138741600006004
   Saleh D, 2017, FRONT PSYCHOL, V8, DOI 10.3389/fpsyg.2017.00019
   Salinas Mendez Méndez Luis Enrique, 2018, Rev Cubana Invest Bioméd, V37, P57
   Schele E, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0149456
   Schiavo-Cardozo D, 2013, CLIN ENDOCRINOL, V79, P807, DOI 10.1111/cen.12114
   Schlarb AA, 2017, NEUROPSYCH DIS TREAT, V13, P1989, DOI 10.2147/NDT.S142067
   Sevincer GM, 2016, KLIN PSIKOFARMAKOL B, V26, P238, DOI 10.5455/bcp.20160322093750
   Silva V, 2013, METAB SYNDR RELAT D, V11, P102, DOI 10.1089/met.2012.0060
   Sinha R, 2019, PHYSIOL BEHAV, V208, DOI 10.1016/j.physbeh.2019.112563
   Stock AA, 2020, SLEEP HEALTH, V6, P32, DOI 10.1016/j.sleh.2019.10.003
   Taylor JM, 2015, PSYCHOL ASSESSMENT, V27, P90, DOI 10.1037/a0038100
   Templeman I, 2021, J APPL PHYSIOL, V130, P1534, DOI 10.1152/japplphysiol.00920.2020
   Tsai JC, 2019, BIOL RES NURS, V21, P510, DOI 10.1177/1099800419861695
   Wang K, 2018, INT J ENDOCRINOL, V2018, DOI 10.1155/2018/9376179
   Wordl Health Organization, WORLD HLTH ORG
   Yahia N, 2017, EAT WEIGHT DISORD-ST, V22, P421, DOI 10.1007/s40519-017-0403-z
   Yahia N, 2017, J COMMUN HEALTH, V42, P674, DOI 10.1007/s10900-016-0304-5
   Yan YW, 2018, SOC BEHAV PERSONAL, V46, P63, DOI 10.2224/sbp.6530
   Zuraikat FM, 2020, J AM HEART ASSOC, V9, DOI 10.1161/JAHA.119.014587
NR 55
TC 21
Z9 22
U1 2
U2 17
PU PNG PUBLICATIONS
PI OAK RIDGE
PA 2205-K OAK RIDGE RD, #115, OAK RIDGE, NC 27310 USA
SN 1945-7359
J9 AM J HEALTH BEHAV
JI Am. J. Health Behav.
PD NOV
PY 2021
VL 45
IS 6
BP 1091
EP 1102
DI 10.5993/AJHB.45.6.12
PG 12
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA YD4BE
UT WOS:000740359100012
PM 34969419
DA 2025-06-11
ER

PT J
AU Marazziti, D
   Rutigliano, G
   Baroni, S
   Landi, P
   Dell'Osso, L
AF Marazziti, Donatella
   Rutigliano, Grazia
   Baroni, Stefano
   Landi, Paola
   Dell'Osso, Liliana
TI Metabolic syndrome and major depression
SO CNS SPECTRUMS
LA English
DT Review
DE Major depression; metabolic syndrome; cardiovascular disease; HPA axis;
   inflammation; leptin; ghrelin
ID MEDITERRANEAN DIETARY PATTERN; AUTONOMIC NERVOUS-SYSTEM; BIPOLAR
   DISORDER; INSULIN-RESISTANCE; WEIGHT-GAIN; MOOD DISORDERS; STRESS
   SYSTEM; HEART-RATE; SYMPTOMS; ASSOCIATION
AB Major depression is associated with a 4-fold increased risk for premature death, largely accounted by cardiovascular disease (CVD). The relationship between depression and CVD is thought to be mediated by the so-called metabolic syndrome (MeS). Epidemiological studies have consistently demonstrated a co-occurrence of depression with MeS components, ie, visceral obesity, dyslipidemia, insulin resistance, and hypertension. Although the exact mechanisms linking MeS to depression are unclear, different hypotheses have been put forward. On the one hand, MeS could be the hallmark of the unhealthy lifestyle habits of depressed patients. On the other, MeS and depression might share common alterations of the stress system, including the hypothalamus-pituitary-adrenal (HPA) axis, the autonomic nervous system, the immune system, and platelet and endothelial function. Both the conditions induce a low grade chronic inflammatory state that, in turn, leads to increased oxidative and nitrosative (O&NS) damage of neurons, pancreatic cells, and endothelium. Recently, neurobiological research revealed that peripheral hormones, such as leptin and ghrelin, which are classically involved in homeostatic energy balance, may play a role in mood regulation. Metabolic risk should be routinely assessed in depressed patients and taken into account in therapeutic decisions. Alternative targets should be considered for innovative antidepressant agents, including cytokines and their receptors, intracellular inflammatory mediators, glucocorticoids receptors, O&NS pathways, and peripheral mediators.
C1 [Marazziti, Donatella; Rutigliano, Grazia; Baroni, Stefano; Landi, Paola; Dell'Osso, Liliana] Univ Pisa, Dipartimento Med Clin & Sperimentale, I-56100 Pisa, Italy.
C3 University of Pisa
RP Marazziti, D (corresponding author), Univ Pisa, Dipartimento Psichiat Neurobiol Farmacol & Biotec, Via Roma 67, I-56100 Pisa, Italy.
EM dmarazzi@psico.med.unipi.i
RI Rutigliano, Grazia/AAO-9072-2020; Baroni, Stefano/AAL-2090-2020
OI Baroni, Stefano/0000-0001-7688-5069; Marazziti,
   Donatella/0000-0002-4021-5829; Rutigliano, Grazia/0000-0001-6014-5357
CR Adamec R, 2006, BEHAV BRAIN RES, V170, P126, DOI 10.1016/j.bbr.2006.02.012
   Ahola AJ, 2010, ANN MED, V42, P495, DOI 10.3109/07853890.2010.503660
   Akbaraly TN, 2011, DIABETES CARE, V34, P904, DOI 10.2337/dc10-1644
   Akbaraly TN, 2009, DIABETES CARE, V32, P499, DOI 10.2337/dc08-1358
   Almeida OP, 2009, AM J GERIAT PSYCHIAT, V17, P889, DOI 10.1097/JGP.0b013e3181b047e3
   [Anonymous], INT J ENDOCRINOL
   Bao AM, 2008, BRAIN RES REV, V57, P531, DOI 10.1016/j.brainresrev.2007.04.005
   Bartoli F, 2013, AM J PSYCHIAT, V170, P927, DOI 10.1176/appi.ajp.2013.13040447
   Benthem L, 2000, AM J PHYSIOL-ENDOC M, V279, pE1286, DOI 10.1152/ajpendo.2000.279.6.E1286
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   Björntorp P, 2000, INT J OBESITY, V24, pS80, DOI 10.1038/sj.ijo.0801285
   Björntorp P, 2000, BRIT J NUTR, V83, pS49, DOI 10.1017/S0007114500000957
   Blank Karen, 2010, J Clin Hypertens (Greenwich), V12, P456, DOI 10.1111/j.1751-7176.2010.00293.x
   Bonnet F, 2005, J HYPERTENS, V23, P611, DOI 10.1097/01.hjh.0000160219.71350.d2
   Bonnet F, 2005, ATHEROSCLEROSIS, V178, P339, DOI 10.1016/j.atherosclerosis.2004.08.035
   Bountziouka V, 2009, J AGING HEALTH, V21, P864, DOI 10.1177/0898264309340693
   Bushe CJ, 2009, INT J CLIN PRACT, V63, P1743, DOI 10.1111/j.1742-1241.2009.02224.x
   Capuron L, 2008, BIOL PSYCHIAT, V64, P896, DOI 10.1016/j.biopsych.2008.05.019
   Carnethon MR, 2003, CIRCULATION, V107, P2190, DOI 10.1161/01.CIR.0000066324.74807.95
   Carney RM, 2005, PSYCHOSOM MED, V67, pS29, DOI 10.1097/01.psy.0000162254.61556.d5
   Catena-Dell'Osso M, 2011, CURR MED CHEM, V18, P245, DOI 10.2174/092986711794088353
   Chi MH, 2013, J AFFECT DISORDERS, V146, P79, DOI 10.1016/j.jad.2012.08.042
   Chokka P, 2006, J PSYCHIATR NEUROSCI, V31, P414
   Cizza G, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0028912
   Czepielewski L, 2013, REV BRAS PSIQUIATR, V35, P88, DOI [10.1016/j.rbp.2012.07.004, 10.1016/j.rbp.2012.00.000]
   Díaz-Martínez L, 2007, REV MED CHILE, V135, P990
   Dortland AKBV, 2010, ACTA PSYCHIAT SCAND, V122, P30, DOI 10.1111/j.1600-0447.2010.01565.x
   Dortland AKBV, 2010, J CLIN PSYCHIAT, V71, P729, DOI 10.4088/JCP.08m04865blu
   Dunn AL, 2005, AM J PREV MED, V28, P1, DOI 10.1016/j.amepre.2004.09.003
   Ehret M, 2010, J CLIN PSYCHIAT, V71, P1286, DOI 10.4088/JCP.09m05274yel
   Everson-Rose SA, 2004, DIABETES CARE, V27, P2856, DOI 10.2337/diacare.27.12.2856
   Fava M, 2000, J CLIN PSYCHIAT, V61, P37
   Festa A, 2000, DIABETES CARE, V23, P624, DOI 10.2337/diacare.23.5.624
   Foley DL, 2010, TWIN RES HUM GENET, V13, P347, DOI 10.1375/twin.13.4.347
   Gans ROB, 2006, MED CLIN N AM, V90, P573, DOI 10.1016/j.mcna.2006.05.002
   Gaysina D, 2011, BRAIN BEHAV IMMUN, V25, P750, DOI 10.1016/j.bbi.2011.01.019
   Gil Katarzyna, 2006, Kardiol Pol, V64, P464
   Gold PW, 2002, MOL PSYCHIATR, V7, P254, DOI 10.1038/sj.mp.4001032
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   GOLDEN RN, 1988, ARCH GEN PSYCHIAT, V45, P150
   Gussinyer S, 2008, MED CLIN-BARCELONA, V131, P245, DOI 10.1016/S0025-7753(08)72243-7
   Hartley TA, 2012, J ENVIRON PUBLIC HEA, V2012, DOI 10.1155/2012/861219
   Heiskanen TH, 2006, J CLIN PSYCHIAT, V67, P1422, DOI 10.4088/JCP.v67n0913
   Hibbeln JR, 1998, LANCET, V351, P1213, DOI 10.1016/S0140-6736(05)79168-6
   Hommel JD, 2006, NEURON, V51, P801, DOI 10.1016/j.neuron.2006.08.023
   Kahl KG, 2012, EUR ARCH PSY CLIN N, V262, P313, DOI 10.1007/s00406-011-0277-4
   Kamezaki F, 2011, INTERNAL MED, V50, P2485, DOI 10.2169/internalmedicine.50.5667
   Kemp DE, 2012, J AFFECT DISORDERS, V136, P1164, DOI 10.1016/j.jad.2011.06.033
   Kemp DE, 2009, AM J PSYCHIAT, V166, P619, DOI 10.1176/appi.ajp.2008.08081195
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178, DOI 10.4088/JCP.v69n0202
   Kozumplik O, 2011, PSYCHIAT DANUB, V23, P84
   Kreier F, 2003, DIABETES, V52, P2652, DOI 10.2337/diabetes.52.11.2652
   Kyrozis A, 2009, J PSYCHIATR RES, V43, P763, DOI 10.1016/j.jpsychires.2008.09.003
   Licht CMM, 2009, HYPERTENSION, V53, P631, DOI 10.1161/HYPERTENSIONAHA.108.126698
   Lu XY, 2007, CURR OPIN PHARMACOL, V7, P648, DOI 10.1016/j.coph.2007.10.010
   Luppino FS, 2011, PSYCHOSOM MED, V73, P257, DOI 10.1097/PSY.0b013e31820a59c0
   Lutter M, 2008, NAT NEUROSCI, V11, P752, DOI 10.1038/nn.2139
   Lutter Michael, 2009, F1000 Biol Rep, V1, P63, DOI 10.3410/B1-63
   Maes M, 1997, ACTA PSYCHIAT SCAND, V95, P212, DOI 10.1111/j.1600-0447.1997.tb09622.x
   Maes M, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-66
   Maiese K, 2007, CURR NEUROVASC RES, V4, P63, DOI 10.2174/156720207779940653
   Malhotra N, 2013, J AFFECT DISORDERS, V150, P653, DOI 10.1016/j.jad.2013.03.010
   Mamplekou E, 2010, J NUTR HEALTH AGING, V14, P449
   Mann JJ, 2005, NEW ENGL J MED, V353, P1819, DOI 10.1056/NEJMra050730
   McIntyre Roger S, 2007, Ann Clin Psychiatry, V19, P257, DOI 10.1080/10401230701653377
   McIntyre RS, 2007, J CLIN PSYCHIAT, V68, P1352, DOI 10.4088/JCP.v68n0905
   McIntyre RS, 2006, EXPERT OPIN DRUG SAF, V5, P523, DOI 10.1517/14740338.5.4.523
   McIntyre RS, 2012, ANN CLIN PSYCHIATRY, V24, P69
   McIntyre RS, 2009, CURR DIABETES REP, V9, P51, DOI 10.1007/s11892-009-0010-0
   Medeiros-Ferreira L, 2013, ACTAS ESP PSIQUIATRI, V41, P17
   Mezzacappa E, 1998, J AM ACAD CHILD PSY, V37, P52, DOI 10.1097/00004583-199801000-00017
   Miettola J, 2008, SCAND J PRIM HEALTH, V26, P203, DOI 10.1080/02813430802117624
   Mohamed-Ali V, 1997, J CLIN ENDOCR METAB, V82, P4196, DOI 10.1210/jc.82.12.4196
   Muhtz C, 2009, PSYCHONEUROENDOCRINO, V34, P1004, DOI 10.1016/j.psyneuen.2009.01.016
   Ösby U, 2001, ARCH GEN PSYCHIAT, V58, P844, DOI 10.1001/archpsyc.58.9.844
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Panzer C, 2002, DIABETES, V51, P803, DOI 10.2337/diabetes.51.3.803
   Pulkki-Råback L, 2009, HEALTH PSYCHOL, V28, P108, DOI 10.1037/a0012646
   Räikkönen K, 2007, DIABETES CARE, V30, P872, DOI 10.2337/dc06-1857
   Teixeira PJR, 2007, REV BRAS PSIQUIATR, V29, P330, DOI 10.1590/S1516-44462007000400007
   Richardson LP, 2003, ARCH PEDIAT ADOL MED, V157, P739, DOI 10.1001/archpedi.157.8.739
   Richter N, 2010, EUR ARCH PSY CLIN N, V260, P41, DOI 10.1007/s00406-009-0013-5
   Rihmer Zoltan, 2008, Neuropsychopharmacol Hung, V10, P183
   Ruetsch O, 2005, ENCEPHALE, V31, P507
   Sadock B.J., 2000, Kaplan Sadock's comprehensive textbook of psychiatry, V7th
   Sánchez-Villegas A, 2006, PUBLIC HEALTH NUTR, V9, P1104, DOI 10.1017/S1368980007668578
   Sánchez-Villegas A, 2006, INT J OBESITY, V30, P350, DOI 10.1038/sj.ijo.0803118
   Sánchez-Villegas A, 2009, J HUM NUTR DIET, V22, P122, DOI 10.1111/j.1365-277X.2008.00931.x
   Sánchez-Villegas A, 2009, ARCH GEN PSYCHIAT, V66, P1090, DOI 10.1001/archgenpsychiatry.2009.129
   Seppälä J, 2012, J AFFECT DISORDERS, V136, P543, DOI 10.1016/j.jad.2011.10.032
   Skibicka KP, 2012, ADDICT BIOL, V17, P95, DOI 10.1111/j.1369-1600.2010.00294.x
   Suttajit S, 2013, NEUROPSYCH DIS TREAT, V9, P941, DOI 10.2147/NDT.S47450
   Takeuchi T, 2009, DIABETES-METAB RES, V25, P762, DOI 10.1002/dmrr.1041
   Tsai AC, 2012, J NUTR HEALTH AGING, V16, P492, DOI 10.1007/s12603-012-0025-0
   Uzun S, 2009, PSYCHIAT DANUB, V21, P91
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
   Valtonen M, 2008, SCAND J PUBLIC HEALT, V36, P795, DOI 10.1177/1403494808094918
   Valtonen MK, 2012, SCAND J PUBLIC HEALT, V40, P674, DOI 10.1177/1403494812461730
   Vancampfort D, 2013, AM J PSYCHIAT, V170, P265, DOI 10.1176/appi.ajp.2012.12050620
   Vanhala M, 2009, ACTA PSYCHIAT SCAND, V119, P137, DOI 10.1111/j.1600-0447.2008.01283.x
   Viinamäki H, 2009, ACTA PSYCHIAT SCAND, V120, P23, DOI 10.1111/j.1600-0447.2008.01333.x
   Viscogliosi G, 2013, INT J GERIATR PSYCH, V28, P242, DOI 10.1002/gps.3817
   Vogelzangs N, 2007, PSYCHONEUROENDOCRINO, V32, P151, DOI 10.1016/j.psyneuen.2006.11.009
   Vogelzangs N, 2011, J CLIN PSYCHIAT, V72, P598, DOI 10.4088/JCP.10m06559
   Wulsin LR, 1999, PSYCHOSOM MED, V61, P6, DOI 10.1097/00006842-199901000-00003
   Yamada N, 2011, ENDOCRINOLOGY, V152, P2634, DOI 10.1210/en.2011-0004
   Yudkin JS, 1999, ARTERIOSCL THROM VAS, V19, P972, DOI 10.1161/01.ATV.19.4.972
NR 108
TC 149
Z9 151
U1 0
U2 42
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1092-8529
EI 2165-6509
J9 CNS SPECTRUMS
JI CNS Spectr.
PD AUG
PY 2014
VL 19
IS 4
BP 293
EP 304
DI 10.1017/S1092852913000667
PG 12
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA AN9RD
UT WOS:000340944500003
PM 24103843
DA 2025-06-11
ER

PT J
AU Winning, A
   Glymour, MM
   McCormick, MC
   Gilsanz, P
   Kubzansky, LD
AF Winning, Ashley
   Glymour, M. Maria
   McCormick, Marie C.
   Gilsanz, Paola
   Kubzansky, Laura D.
TI Childhood Psychological Distress as a Mediator in the Relationship
   Between Early-Life Social Disadvantage and Adult Cardiometabolic Risk:
   Evidence From the 1958 British Birth Cohort
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE prospective cohort; biomarkers; mediation
ID HEART-DISEASE; CARDIOVASCULAR-DISEASE; ANXIETY DISORDERS; HEALTH;
   ADVERSITY; PATHWAYS; STRESS; INFLAMMATION; OBESITY; PSYCHOPATHOLOGY
AB Objectives: Prior research on the relationship between early adversity and adult chronic disease has often relied on retrospective reports of a limited range of exposures and has not considered childhood psychological distress as a mediator. We investigate whether distress in childhood is one pathway by which early social disadvantage leads to greater cardiometabolic risk in middle adulthood.
   Methods: Data are from the 1958 British Birth Cohort study (sample n = 6027). We created an early social disadvantage index based on 16 exposures related to family and socioeconomic hardship from birth to age 7. Childhood psychological distress was ascertained from internalizing and externalizing symptoms at ages 7, 11, and 16 years. Cardiometabolic risk was assessed with a Z-standardized score derived from 9 immune, cardiovascular, and metabolic biomarkers measured at age 45. We used linear regression models and formal tests of mediation to assess relationships between disadvantage, distress, and subsequent cardiometabolic risk.
   Results: Higher social disadvantage predicted increased adult cardiometabolic risk (beta = 0.05; 95% CI = 0.03-0.07). Mediation analyses revealed a significant direct (path c'; beta = 0.03; 95% CI = 0.01-0.05) and indirect (path ab; beta = 0.02; 95% CI = 0.01-0.02) effect of social disadvantage on cardiometabolic risk, adjusting for potential confounders. Child psychological distress accounted for 37% (95% CI = 34-46%) of the observed association.
   Conclusions: Results suggest childhood distress may be one factor on the pathway linking early disadvantage to higher risk of developing cardiometabolic diseases. Such results may point to the importance of blocking the translation of psychosocial to biological risk during a potentially sensitive developmental window.
C1 [Winning, Ashley; McCormick, Marie C.; Gilsanz, Paola; Kubzansky, Laura D.] Harvard TH Chan Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA USA.
   [Glymour, M. Maria] Univ Calif San Francisco, Sch Med, Dept Epidemiol & Biostat, San Francisco, CA USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health;
   University of California System; University of California San Francisco
RP Winning, A (corresponding author), Econ Mobil Pathways EMPath, Res & Evaluat Dept, 1 Washington Mall,3rd Floor, Boston, MA 02108 USA.
EM awinning@empathways.org
RI Glymour, Maria/AEM-8841-2022
FU Julius B Richmond Fellowship at the Harvard Center on the Developing
   Child; Martha May Eliot Fund at the Harvard School of Public Health
FX Dr Winning was supported by the Julius B Richmond Fellowship at the
   Harvard Center on the Developing Child and by the Martha May Eliot Fund
   at the Harvard School of Public Health. This research received no
   specific grant from any funding agency, commercial, or not-for-profit
   sectors. The authors report no conflicts of interest.
CR ANDA RF, 1990, JAMA-J AM MED ASSOC, V264, P1541, DOI 10.1001/jama.264.12.1541
   [Anonymous], 2006, METHODS SOCIAL EPIDE
   Atherton K, 2008, J EPIDEMIOL COMMUN H, V62, P216, DOI 10.1136/jech.2006.058966
   Clark C, 2007, ARCH GEN PSYCHIAT, V64, P668, DOI 10.1001/archpsyc.64.6.668
   Clark C, 2010, ANN EPIDEMIOL, V20, P385, DOI 10.1016/j.annepidem.2010.02.008
   Crimmins EM, 2004, POPUL DEV REV, V30, P89
   Danese A, 2011, MOL PSYCHIATR, V16, P244, DOI 10.1038/mp.2010.5
   Danese A, 2007, P NATL ACAD SCI USA, V104, P1319, DOI 10.1073/pnas.0610362104
   Dong MX, 2004, CIRCULATION, V110, P1761, DOI 10.1161/01.CIR.0000143074.54995.7F
   Evans GW, 2012, PEDIATRICS, V129, pE68, DOI 10.1542/peds.2010-3647
   Flouri E, 2007, J AM ACAD CHILD PSY, V46, P1651, DOI 10.1097/chi.0b013e318156a81a
   Fuller E., 2006, TECHNICAL REPORT NAT
   Galobardes B, 2006, ANN EPIDEMIOL, V16, P91, DOI 10.1016/j.annepidem.2005.06.053
   Ghodsian M, 1977, BRIT J SOC PSYCHOL, P16
   Green JG, 2010, ARCH GEN PSYCHIAT, V67, P113, DOI 10.1001/archgenpsychiatry.2009.186
   Hayes A. F., 2017, INTRO MEDIATION MODE
   Hazell P, 2007, CURR OPIN PSYCHIATR, V20, P315, DOI 10.1097/YCO.0b013e3281a7368d
   Hertzman C, 1999, ANN NY ACAD SCI, V896, P85, DOI 10.1111/j.1749-6632.1999.tb08107.x
   Jaffee SR, 2007, CHILD ABUSE NEGLECT, V31, P231, DOI 10.1016/j.chiabu.2006.03.011
   Juster RP, 2010, NEUROSCI BIOBEHAV R, V35, P2, DOI 10.1016/j.neubiorev.2009.10.002
   Kelly-Irving M, 2013, EUR J EPIDEMIOL, V28, P721, DOI 10.1007/s10654-013-9832-9
   Kelly-Irving M, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-767
   Kendall-Tackett K, 2002, CHILD ABUSE NEGLECT, V26, P715, DOI 10.1016/S0145-2134(02)00343-5
   Kessler RC, 1997, PSYCHOL MED, V27, P1101, DOI 10.1017/S0033291797005588
   Kuzawa CW, 2009, AM J HUM BIOL, V21, P2, DOI 10.1002/ajhb.20822
   Lloyd-Jones DM, 2010, CIRCULATION, V121, P586, DOI 10.1161/CIRCULATIONAHA.109.192703
   Loucks EB, 2011, PSYCHOSOM MED, V73, P563, DOI 10.1097/PSY.0b013e318228c820
   MacKinnon DP, 2002, PSYCHOL METHODS, V7, P83, DOI 10.1037/1082-989X.7.1.83
   Marino M, 2014, AM J PREV MED, V47, P131, DOI 10.1016/j.amepre.2014.03.006
   Matthews KA, 2010, ANN NY ACAD SCI, V1186, P146, DOI 10.1111/j.1749-6632.2009.05332.x
   Mausbach BT, 2012, HEALTH PSYCHOL, V31, P433, DOI 10.1037/a0027783
   Miller GE, 2011, PSYCHOL BULL, V137, P959, DOI 10.1037/a0024768
   Min MO, 2013, CHILD ABUSE NEGLECT, V37, P361, DOI 10.1016/j.chiabu.2012.09.008
   Nandi A, 2012, EPIDEMIOLOGY, V23, P223, DOI 10.1097/EDE.0b013e31824570bd
   Nemeroff CB, 2004, J CLIN PSYCHIAT, V65, P18
   Non AL, 2014, AM J EPIDEMIOL, V180, P263, DOI 10.1093/aje/kwu127
   Pearson TA, 2003, CIRCULATION, V107, P499, DOI 10.1161/01.CIR.0000052939.59093.45
   Power C, 2006, INT J EPIDEMIOL, V35, P34, DOI 10.1093/ije/dyi183
   Power C, 1997, BRIT MED BULL, V53, P210
   Preacher KJ, 2004, BEHAV RES METH INS C, V36, P717, DOI 10.3758/BF03206553
   Preacher KJ, 2008, BEHAV RES METHODS, V40, P879, DOI 10.3758/BRM.40.3.879
   Richiardi L, 2013, INT J EPIDEMIOL, V42, P1511, DOI 10.1093/ije/dyt127
   Roy-Byrne PP, 2008, GEN HOSP PSYCHIAT, V30, P208, DOI 10.1016/j.genhosppsych.2007.12.006
   RUTTER M, 1967, J CHILD PSYCHOL PSYC, V8, P1, DOI 10.1111/j.1469-7610.1967.tb02175.x
   Schafer JL, 1997, ANAL INCOMPLETE MULT
   Shepherd P., 2008, USER GUIDE BIOMEDICA
   Slopen N, 2013, PSYCHONEUROENDOCRINO, V38, P188, DOI 10.1016/j.psyneuen.2012.05.013
   Spann SJ, 2014, GEN HOSP PSYCHIAT, V36, P150, DOI 10.1016/j.genhosppsych.2013.10.004
   Szmitko Paul E, 2006, J Cardiometab Syndr, V1, P66, DOI 10.1111/j.0197-3118.2006.05340.x
   Tamayo T, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-525
   Taylor SE, 2006, BIOL PSYCHIAT, V60, P819, DOI 10.1016/j.biopsych.2006.03.016
   Thomas C, 2008, PEDIATRICS, V121, pE1240, DOI 10.1542/peds.2007-2403
   Tottenham N, 2010, FRONT HUM NEUROSCI, V3, DOI 10.3389/neuro.09.068.2009
   VanderWeele TJ, 2009, STAT INTERFACE, V2, P457
   Vansteelandt S, 2009, EPIDEMIOLOGY, V20, P851, DOI 10.1097/EDE.0b013e3181b6f4c9
   von Stumm S, 2011, J CHILD PSYCHOL PSYC, V52, P992, DOI 10.1111/j.1469-7610.2011.02373.x
   Winning A, 2015, J AM COLL CARDIOL, V66, P1577, DOI 10.1016/j.jacc.2015.08.021
NR 57
TC 8
Z9 9
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD NOV-DEC
PY 2016
VL 78
IS 9
BP 1019
EP 1030
DI 10.1097/PSY.0000000000000409
PG 12
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA EE5LR
UT WOS:000389649600006
PM 27763989
DA 2025-06-11
ER

PT J
AU Gancheva, S
   Galunska, B
   Zhelyazkova-Savova, M
AF Gancheva, Silvia
   Galunska, Bistra
   Zhelyazkova-Savova, Maria
TI Diets rich in saturated fat and fructose induce anxiety and
   depression-like behaviours in the rat: is there a role for lipid
   peroxidation?
SO INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
LA English
DT Article
DE anxiety-like behaviour; depression-like behaviour; high-fat diet;
   high-fat high-fructose diet; lipid peroxidation; rats
ID OXIDATIVE STRESS; METABOLIC DISTURBANCES; DOWN-REGULATION; INDUCED
   OBESITY; MEMORY; DISORDERS; COGNITION; WESTERN; BRAIN; ASSOCIATION
AB Epidemiological studies reveal associations between obesity/metabolic syndrome and mood disorders. We assessed behavioural changes in rats fed diets enriched in fat and fructose in different proportions and correlated the observed alterations with biochemical changes induced by the diets. Three groups of rats were used as follows: control (C) animals fed regular rat chow, rats fed high-fat diet (HF) and rats fed high-fat and high-fructose diet (HFHF). HF and HFHF animals were also given a 10% fructose solution as drinking water. Behavioural and biochemical parameters were determined. Anxiety was measured by the open-field and the social interaction test. Depression-like behaviour was evaluated by the forced swimming test. The object recognition test was utilized to assess effects on memory. Diet-exposed animals displayed signs of anxiety in the open-field (HF rats had reduced central time; HFHF rats had reduced number of central entries) and in the social interaction test (decreased time of interaction in HF group). In the forced swimming test, the immobility time was prolonged in the HFHF group. While different measures of anxiety scores correlated with visceral adiposity and dyslipidemia, results from both social interaction and forced swimming tests were significantly associated with lipid peroxidation, which in turn also correlated with the metabolic parameters. The experimental diets did not affect the object recognition memory. Both experimental diets induced metabolic derangements in rats and provoked similar anxiety- and depression-like behaviours. Lipid peroxidation seems to play a role in translating diet-induced metabolic alterations into behavioural disorders.
C1 [Gancheva, Silvia; Zhelyazkova-Savova, Maria] Med Univ Varna, Dept Pharmacol & Clin Pharmacol & Therapeut, Varna, Bulgaria.
   [Galunska, Bistra] Med Univ Varna, Dept Biochem Mol Med & Nutrigen, Varna, Bulgaria.
C3 Medical University Varna; Medical University Varna
RP Zhelyazkova-Savova, M (corresponding author), Med Univ Varna, Dept Preclin & Clin Pharmacol, 55 Marin Drinov St, Varna 9002, Bulgaria.
EM mariadz52@yahoo.com
RI Zhelyazkova-Savova, Maria/J-7538-2019; Gancheva, Silvia/ITV-5331-2023
OI Zhelyazkova-Savova, Maria/0000-0003-1132-8813; Gancheva,
   Silvia/0000-0001-5101-7716; Galunska, Bistra/0000-0002-2937-2874
FU Medical University of Varna, Bulgaria
FX The study was funded with personal sources and supported by the Medical
   University of Varna, Bulgaria.
CR Amin KA, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-74
   Anderson RA, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0083243
   [Anonymous], 2006, The IDF Consensus Worldwide Definition of the Metabolic Syndrome
   Bogdanova OV, 2013, PHYSIOL BEHAV, V118, P227, DOI 10.1016/j.physbeh.2013.05.012
   Bouayed J, 2007, EUR J PHARMACOL, V564, P146, DOI 10.1016/j.ejphar.2007.02.055
   Bouayed J, 2009, OXID MED CELL LONGEV, V2, P63, DOI 10.4161/oxim.2.2.7944
   Broadbent NJ, 2004, P NATL ACAD SCI USA, V101, P14515, DOI 10.1073/pnas.0406344101
   Buchenauer T, 2009, PHYSIOL BEHAV, V98, P563, DOI 10.1016/j.physbeh.2009.09.003
   Can ÖD, 2012, BEHAV PHARMACOL, V23, P582, DOI 10.1097/FBP.0b013e328356c3f2
   Carter M.Shieh., 2015, Guide to Research Techniques in Neuroscience, V2nd
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Cohen SJ, 2013, CURR BIOL, V23, P1685, DOI 10.1016/j.cub.2013.07.002
   Couturier K, 2010, ARCH BIOCHEM BIOPHYS, V501, P158, DOI 10.1016/j.abb.2010.05.032
   Crescenzo R, 2014, EXP PHYSIOL, V99, P1203, DOI 10.1113/expphysiol.2014.079632
   Elias Merrill F, 2005, Neurobiol Aging, V26 Suppl 1, P11, DOI 10.1016/j.neurobiolaging.2005.08.019
   ENNACEUR A, 1988, BEHAV BRAIN RES, V31, P47, DOI 10.1016/0166-4328(88)90157-X
   FILE SE, 1978, BRIT J PHARMACOL, V62, P19, DOI 10.1111/j.1476-5381.1978.tb07001.x
   Freeman LR, 2014, NUTR NEUROSCI, V17, P241, DOI 10.1179/1476830513Y.0000000092
   Gajda A., 2007, DIET INDUCED METABOL
   Gariepy G, 2010, INT J OBESITY, V34, P407, DOI 10.1038/ijo.2009.252
   Gould TD, 2009, NEUROMETHODS, V42, P1, DOI 10.1007/978-1-60761-303-9_1
   Grases G, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/430216
   Grillo CA, 2007, PHYSIOL BEHAV, V92, P691, DOI 10.1016/j.physbeh.2007.05.043
   Grillo CA, 2011, BEHAV BRAIN RES, V222, P230, DOI 10.1016/j.bbr.2011.03.052
   Grillo CA, 2011, PHYSIOL BEHAV, V105, P138, DOI 10.1016/j.physbeh.2011.02.028
   Hoffman K.L., 2016, Modeling neuropsychiatric disorders in laboratory animals
   Hopps E, 2010, NUTR METAB CARDIOVAS, V20, P72, DOI 10.1016/j.numecd.2009.06.002
   Hovatta I, 2010, NEUROSCI RES, V68, P261, DOI 10.1016/j.neures.2010.08.007
   Hryhorczuk C, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00177
   Iemolo A, 2013, NEUROPSYCHOPHARMACOL, V38, P2456, DOI 10.1038/npp.2013.147
   Jurdak N, 2008, NUTR NEUROSCI, V11, P48, DOI 10.1179/147683008X301333
   Jurdak N, 2009, PHYSIOL BEHAV, V96, P1, DOI 10.1016/j.physbeh.2008.07.023
   Kanoski SE, 2010, J EXP PSYCHOL-ANIM B, V36, P313, DOI 10.1037/a0017228
   Kirkham TC, 2009, INT REV PSYCHIATR, V21, P163, DOI 10.1080/09540260902782810
   Kosari S, 2012, BEHAV BRAIN RES, V235, P98, DOI 10.1016/j.bbr.2012.07.017
   LALANZA JF, 2014, EFFECTS OF A POST WE, V9, DOI DOI 10.1371/JOURNAL.PONE.0085049
   Lykouras L, 2011, Psychiatriki, V22, P307
   Marwitz SE, 2015, PHYSIOL BEHAV, V151, P147, DOI 10.1016/j.physbeh.2015.07.023
   McElroy SL, 2004, J CLIN PSYCHIAT, V65, P634
   McIntyre Roger S, 2007, Ann Clin Psychiatry, V19, P257, DOI 10.1080/10401230701653377
   McNay EC, 2010, NEUROBIOL LEARN MEM, V93, P546, DOI 10.1016/j.nlm.2010.02.002
   McNeilly AD, 2015, PSYCHONEUROENDOCRINO, V52, P272, DOI 10.1016/j.psyneuen.2014.12.002
   Moulton CD, 2015, LANCET DIABETES ENDO, V3, P461, DOI 10.1016/S2213-8587(15)00134-5
   Murphy M, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/701967
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   Panchal SK, 2011, J BIOMED BIOTECHNOL, DOI 10.1155/2011/351982
   Paola V., 2011, Object Recognition, DOI DOI 10.5772/14667
   Park HR, 2010, NEUROSCI LETT, V482, P235, DOI 10.1016/j.neulet.2010.07.046
   PORSOLT RD, 1979, BIOMEDICINE, V30, P139
   Samra R.A., 2010, TASTE TEXTURE POST I
   Sharma S, 2013, INT J OBESITY, V37, P382, DOI 10.1038/ijo.2012.48
   Simon GE, 2006, ARCH GEN PSYCHIAT, V63, P824, DOI 10.1001/archpsyc.63.7.824
   Sivanathan S, 2015, BEHAV BRAIN RES, V286, P265, DOI 10.1016/j.bbr.2015.02.036
   Smaga I, 2015, PHARMACOL REP, V67, P569, DOI 10.1016/j.pharep.2014.12.015
   Souza CG, 2007, LIFE SCI, V81, P198, DOI 10.1016/j.lfs.2007.05.001
   Tordoff MG, 2008, PHYSIOL BEHAV, V95, P308, DOI 10.1016/j.physbeh.2008.06.010
   Warneke W, 2014, PHARMACOL BIOCHEM BE, V116, P45, DOI 10.1016/j.pbb.2013.11.016
   Wilson CR, 2007, BIOCHEM J, V406, P457, DOI 10.1042/BJ20070392
   Yamada-Goto N., 2013, FUNCTIONAL BRAIN MAP
   Yates KF, 2012, ARTERIOSCL THROM VAS, V32, P2060, DOI 10.1161/ATVBAHA.112.252759
   Zafir A, 2009, PROG NEURO-PSYCHOPH, V33, P220, DOI 10.1016/j.pnpbp.2008.11.010
   Zhang XC, 2005, EXP NEUROL, V191, P318, DOI 10.1016/j.expneurol.2004.10.011
NR 62
TC 48
Z9 51
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0959-9673
EI 1365-2613
J9 INT J EXP PATHOL
JI Int. J. Exp. Pathol.
PD OCT
PY 2017
VL 98
IS 5
BP 296
EP 306
DI 10.1111/iep.12254
PG 11
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA FR1KW
UT WOS:000418826700006
PM 29210119
OA Green Published
DA 2025-06-11
ER

PT J
AU Tyagi, A
   Cohen, M
   Reece, J
   Telles, S
   Jones, L
AF Tyagi, Anupama
   Cohen, Marc
   Reece, John
   Telles, Shirely
   Jones, Linda
TI Heart Rate Variability, Flow, Mood and Mental Stress During Yoga
   Practices in Yoga Practitioners, Non-yoga Practitioners and People with
   Metabolic Syndrome
SO APPLIED PSYCHOPHYSIOLOGY AND BIOFEEDBACK
LA English
DT Article
DE Meditation; Pranayama; Reactivity and recovery; Autonomic flexibility;
   Mood and flow experience
ID AUTONOMIC NERVOUS-SYSTEM; BLOOD-PRESSURE REACTIONS; CARDIOVASCULAR RISK;
   FOLLOW-UP; INSULIN-RESISTANCE; VAGAL TONE; MEDITATION; REACTIVITY;
   RESPONSES; DISEASE
AB Heart Rate Variability (HRV) and respiratory sinus arrhythmia are directly associated with autonomic flexibility, self-regulation and well-being, and inversely associated with physiological stress, psychological stress and pathology. Yoga enhances autonomic activity, mitigates stress and benefits stress-related clinical conditions, yet the relationship between autonomic activity and psychophysiological responses during yoga practices and stressful stimuli has not been widely explored. This experimental study explored the relationship between HRV, mood states and flow experiences in regular yoga practitioners (YP), non-yoga practitioners (NY) and people with metabolic syndrome (MetS), during Mental Arithmetic Stress Test (MAST) and various yoga practices. The study found that the MAST placed a cardio-autonomic burden in all participants with the YP group showing the greatest reactivity and the most rapid recovery, while the MetS group had significantly blunted recovery. The YP group also reported a heightened experience of flow and positive mood states compared to NY and MetS groups as well as having a higher vagal tone during all resting conditions. These results suggest yoga practitioners have a greater homeostatic capacity and autonomic, metabolic and physiological resilience. Further studies are now needed to determine if regular yoga practice may improve autonomic flexibility in non-yoga practitioners and metabolic syndrome patients.
   Clinical Trial No 'ACTRN 2614001075673'.
C1 [Tyagi, Anupama; Cohen, Marc; Jones, Linda] RMIT Univ, Sch Hlth Sci, Bundoora, Vic 3083, Australia.
   [Reece, John] Australian Coll Appl Psychol, Melbourne, Vic 3000, Australia.
   [Telles, Shirely] Patanjali Res Fdn, Haridwar 249402, Uttrakhand, India.
C3 Royal Melbourne Institute of Technology (RMIT); Australian College of
   Applied Psychology
RP Cohen, M (corresponding author), RMIT Univ, Sch Hlth Sci, Bundoora, Vic 3083, Australia.
EM marc.cohen@rmit.edu.au
RI Telles, Shirley/U-7154-2019; Jones, Linda/GXG-2821-2022; Cohen,
   Marc/GWV-0933-2022
OI Jones, Linda K/0000-0002-2116-8545; Cohen, Marc/0000-0002-5876-6565;
   Telles, Shirley/0000-0003-3562-1926
CR [Anonymous], 2008, NEW
   [Anonymous], 1975, The Relaxation Response
   Bharshankar Jyotsana R., 2003, Indian Journal of Physiology and Pharmacology, V47, P202
   Bowman AJ, 1997, EUR J CLIN INVEST, V27, P443, DOI 10.1046/j.1365-2362.1997.1340681.x
   Camm AJ, 1996, CIRCULATION, V93, P1043
   Carroll D, 2012, PSYCHOPHYSIOLOGY, V49, P1444, DOI 10.1111/j.1469-8986.2012.01463.x
   Carroll D, 2011, PSYCHOSOM MED, V73, P737, DOI 10.1097/PSY.0b013e3182359808
   Carroll D, 2009, PSYCHOPHYSIOLOGY, V46, P270, DOI 10.1111/j.1469-8986.2008.00762.x
   Chaya M S, 2006, BMC Complement Altern Med, V6, P28, DOI 10.1186/1472-6882-6-28
   Chida Y, 2008, PSYCHOL BULL, V134, P829, DOI 10.1037/a0013342
   Chida Y, 2010, HYPERTENSION, V55, P1026, DOI 10.1161/HYPERTENSIONAHA.109.146621
   Danucalov MAD, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/513149
   DILLBECK MC, 1987, AM PSYCHOL, V42, P879, DOI 10.1037/0003-066X.42.9.879
   ELSON BD, 1977, PSYCHOPHYSIOLOGY, V14, P52, DOI 10.1111/j.1469-8986.1977.tb01155.x
   Flaa A, 2006, HYPERTENSION, V47, P396, DOI 10.1161/01.HYP.0000203952.27988.79
   Flaa A, 2008, METABOLISM, V57, P1422, DOI 10.1016/j.metabol.2008.05.012
   Flaa A, 2008, HYPERTENSION, V52, P336, DOI 10.1161/HYPERTENSIONAHA.108.111625
   GOLEMAN DJ, 1976, J CONSULT CLIN PSYCH, V44, P456, DOI 10.1037/0022-006X.44.3.456
   Gothe N, 2013, J PHYS ACT HEALTH, V10, P488, DOI 10.1123/jpah.10.4.488
   Graham JW, 2009, ANNU REV PSYCHOL, V60, P549, DOI 10.1146/annurev.psych.58.110405.085530
   Granath Jens, 2006, Cognitive Behaviour Therapy, V35, P3, DOI 10.1080/16506070500401292
   Heathers JAJ, 2014, FRONT PHYSIOL, V5, DOI 10.3389/fphys.2014.00177
   Heponiemi T, 2007, HEALTH PSYCHOL, V26, P13, DOI 10.1037/0278-6133.26.1.13
   Huang FJ, 2013, J NURS RES, V21, P59, DOI 10.1097/jnr.0b013e3182829d6d
   IDF, 2005, IDF CONC WORLDW DEF
   Innes KE, 2005, J AM BOARD FAM PRACT, V18, P491, DOI 10.3122/jabfm.18.6.491
   Jarczok MN, 2013, NEUROSCI BIOBEHAV R, V37, P1810, DOI 10.1016/j.neubiorev.2013.07.004
   Khattab K, 2007, EVID-BASED COMPL ALT, V4, P511, DOI 10.1093/ecam/nem087
   Lehrer P.M., 2007, Principles and Practice of Stress Management, P227
   Lehrer P.M., 2007, Principles and practice of stress management, V3rd
   Lehrer P, 2009, BIOL PSYCHOL, V81, P24, DOI 10.1016/j.biopsycho.2009.01.003
   LEHRER PM, 1980, BEHAV RES THER, V18, P293, DOI 10.1016/0005-7967(80)90088-1
   MALLIANI A, 1991, CIRCULATION, V84, P482, DOI 10.1161/01.CIR.84.2.482
   Mason H, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/743504
   McEwen BS, 1998, ANN NY ACAD SCI, V840, P33, DOI 10.1111/j.1749-6632.1998.tb09546.x
   Muralikrishnan Krishnan, 2012, J Ayurveda Integr Med, V3, P91, DOI 10.4103/0975-9476.96528
   Organization WH, 2011, Waist Circumference and Waist-Hip Ratio: Report of a WHO Expert Consultation
   Peifer C, 2012, ADVANCES IN FLOW RESEARCH, P139, DOI 10.1007/978-1-4614-2359-1_8
   Porges S.W., 2011, The Polyvagal Theory: Neurophysiological Foundations of Emotions, Attachment, Communication, Self-Regulation
   Razzini C, 2008, J CARDIOVASC MED, V9, P761, DOI 10.2459/JCM.0b013e3282f39494
   Santaella Danilo F, 2014, MedicalExpress (São Paulo, online), V1, P233, DOI 10.5935/MedicalExpress.2014.05.04
   Saraswati N., 1994, PRANA PRANAYAMA PRAN
   Selye H., 1983, SELYES GUIDE STRESS
   Selye H., 1975, STRESS LIFE
   Sharma G, 2007, J BODYW MOV THER, V11, P173, DOI 10.1016/j.jbmt.2007.01.002
   Souza GGL, 2007, STRESS, V10, P368, DOI 10.1080/10253890701419886
   Streeter CC, 2012, MED HYPOTHESES, V78, P571, DOI 10.1016/j.mehy.2012.01.021
   Takahashi T, 2005, INT J PSYCHOPHYSIOL, V55, P199, DOI 10.1016/j.ijpsycho.2004.07.004
   Tang YY, 2009, P NATL ACAD SCI USA, V106, P8865, DOI 10.1073/pnas.0904031106
   Tarvainen MP, 2009, IFMBE PROC, V22, P1022
   Taylor AG, 2010, EXPLORE-NY, V6, P29, DOI 10.1016/j.explore.2009.10.004
   Telles S, 2014, MED SCI MONIT BASIC, V20, P184, DOI 10.12659/MSMBR.892063
   Thayer JF, 2012, NEUROSCI BIOBEHAV R, V36, P747, DOI 10.1016/j.neubiorev.2011.11.009
   Thayer JF, 2010, INT J CARDIOL, V141, P122, DOI 10.1016/j.ijcard.2009.09.543
   Thayer JF, 2009, ANN BEHAV MED, V37, P141, DOI 10.1007/s12160-009-9101-z
   Tyagi A, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-445
   van de Weijer T, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0051648
   Weber CS, 2010, EUR J APPL PHYSIOL, V109, P201, DOI 10.1007/s00421-009-1341-x
   Wenneberg SR, 1997, INT J NEUROSCI, V89, P15, DOI 10.3109/00207459708988461
   Wu SD, 2008, BIOMED RES-TOKYO, V29, P245, DOI 10.2220/biomedres.29.245
   Wyrwich KW, 2011, QUAL LIFE RES, V20, P1111, DOI 10.1007/s11136-011-9846-2
   Yadav Raj Kumar, 2012, Int J Yoga, V5, P134, DOI 10.4103/0973-6131.98235
NR 62
TC 24
Z9 29
U1 2
U2 14
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1090-0586
EI 1573-3270
J9 APPL PSYCHOPHYS BIOF
JI Appl. Psychophysiol. Biofeedback
PD DEC
PY 2016
VL 41
IS 4
BP 381
EP 393
DI 10.1007/s10484-016-9340-2
PG 13
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA ED6MR
UT WOS:000388970200003
PM 27457341
DA 2025-06-11
ER

PT J
AU Liang, YJ
   Zou, LL
   Tian, YL
   Zhou, S
   Chen, XH
   Lin, CL
AF Liang, Yinji
   Zou, Lili
   Tian, Yaling
   Zhou, Shuang
   Chen, Xinhe
   Lin, Chenli
TI Dietary and metabolic risk of neuropsychiatric disorders: insights from
   animal models
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Diet; Neuropsychiatric disorders; Depression; Metabolic risk; Animal
   model
ID HIGH-FAT-DIET; DEPRESSIVE-LIKE BEHAVIOR; ANXIETY-LIKE BEHAVIOR; 5-HT3
   RECEPTOR ANTAGONIST; TYPE-2 DIABETES-MELLITUS; TLR4 UP-REGULATION;
   INDUCED-OBESITY; OXIDATIVE STRESS; GUT MICROBIOTA; LIVER-DISEASE
AB Neuropsychiatric disorders are major causes of the global burden of diseases, frequently co-occurring with multiple co-morbidities, especially obesity, type 2 diabetes mellitus, non-alcoholic fatty liver disease and its various risk factors in the metabolic syndrome. While the determining factors of neuropsychiatric disorders are complex, recent studies have shown that there is a strong link between diet, metabolic state and neuropsychiatric disorders, including anxiety and depression. There is no doubt that rodent models are of great value for preclinical research. Therefore, this article focuses on a rodent model of chronic consumption of high-fat diet (HFD), and/or the addition of a certain amount of cholesterol or sugar, meanwhile, summarising the pattern of diet that induces anxiety/depressive-like behaviour and the underlying mechanism. We highlight how dietary and metabolic risk influence neuropsychiatric behaviour in animals. Changes in dietary patterns, especially HFD, can induce anxiety- or depression-like behaviours, which may vary by diet exposure period, sex, age, species and genetic background of the animals used. Furthermore, dietary patterns significantly aggravate anxiety/depression-like behaviour in animal models of neuropsychiatric disorders. The mechanisms by which diet induces anxiety/depressive-like behaviour may involve neuroinflammation, neurotransmitters/neuromodulators, neurotrophins and the gut-brain axis. Future research should be focused on elucidating the mechanism and identifying the contribution of diet and diet-induced metabolic risk to neuropsychiatric disorders, which can form the basis for future clinical dietary intervention strategies for neuropsychiatric disorders.
C1 [Liang, Yinji; Zhou, Shuang] Jinan Univ, Sch Nursing, 601 Huangpu Ave West, Guangzhou 510632, Guangdong, Peoples R China.
   [Zou, Lili; Tian, Yaling; Lin, Chenli] Jinan Univ, Sch Med, 601 Huangpu Ave West, Guangzhou 510632, Guangdong, Peoples R China.
   [Chen, Xinhe] Jinan Univ, Sch Stomatol, 601 Huangpu Ave West, Guangzhou 510632, Guangdong, Peoples R China.
C3 Jinan University; Jinan University; Jinan University
RP Lin, CL (corresponding author), Jinan Univ, Sch Med, 601 Huangpu Ave West, Guangzhou 510632, Guangdong, Peoples R China.
EM igene@foxmail.com
RI Zou, Lili/ABC-2888-2021; liang, yinji/AGV-5846-2022; Lin,
   Chen-Li/AAT-9605-2021; Chen, Xinhe/KKL-9119-2024; Tian,
   Jia-yue/HNJ-1853-2023
FU Traditional Chinese Medicine Bureau of Guangdong in China [20161065,
   20201075]; National Health and Family Planning Commission of Guangdong
   in China [A2016583, A2017228, A2017140, A2020137, A2021374]; Natural
   Science Foundation of Guangdong in China [2016A030313824]; Undergraduate
   Training Programs for Innovation and Entrepreneurship of Jinan
   University in China [CX20157, CX20145]; 'Challenge Cup' Undergraduate
   Academic Science and Technology Curriculum of Jinan University in China
   [19113028]; 22nd Batch of Teaching Reform Research Projects of Jinan
   University [JG2020080]; Teaching Quality and Teaching Reform Project of
   Undergraduate University of Guangdong in China (2017); Teaching Quality
   and Teaching Reform Project of Undergraduate University of Guangdong in
   China (2020)
FX This work was supported in part by the Traditional Chinese Medicine
   Bureau of Guangdong in China (no. 20161065 and 20201075), the National
   Health and Family Planning Commission of Guangdong in China (no.
   A2016583, A2017228, A2017140, A2020137 and A2021374), the Natural
   Science Foundation of Guangdong in China (no. 2016A030313824), the
   Undergraduate Training Programs for Innovation and Entrepreneurship of
   Jinan University in China (no. CX20157 and CX20145), the `Challenge Cup'
   Undergraduate Academic Science and Technology Curriculum of Jinan
   University in China (no. 19113028), the 22nd Batch of Teaching Reform
   Research Projects of Jinan University (JG2020080) and Teaching Quality
   and Teaching Reform Project of Undergraduate University of Guangdong in
   China (2017 and 2020).
CR Abildgaard A, 2017, PSYCHONEUROENDOCRINO, V79, P40, DOI 10.1016/j.psyneuen.2017.02.014
   Abildgaard A, 2011, PSYCHONEUROENDOCRINO, V36, P623, DOI 10.1016/j.psyneuen.2010.09.004
   Adan RAH, 2019, EUR NEUROPSYCHOPHARM, V29, P1321, DOI 10.1016/j.euroneuro.2019.10.011
   Agusti A, 2018, MOL NEUROBIOL, V55, P5337, DOI 10.1007/s12035-017-0768-z
   Akil H, 2018, NEUROSCI BIOBEHAV R, V84, P272, DOI 10.1016/j.neubiorev.2017.08.019
   Allen NB, 2003, PSYCHOL BULL, V129, P887, DOI 10.1037/0033-2909.129.6.887
   Almeida-Suhett CP, 2017, PHYSIOL BEHAV, V169, P130, DOI 10.1016/j.physbeh.2016.11.016
   Alonso-Caraballo Y, 2019, BEHAV BRAIN RES, V360, P81, DOI 10.1016/j.bbr.2018.12.002
   Andrade L, 2003, INT J METH PSYCH RES, V12, P3, DOI 10.1002/mpr.138
   André C, 2014, BRAIN BEHAV IMMUN, V41, P10, DOI 10.1016/j.bbi.2014.03.012
   [Anonymous], 2016, Lancet, V388, P1459, DOI DOI 10.1016/s0140-6736(16)31678-6
   Arcego DM, 2018, MOL NEUROBIOL, V55, P2740, DOI 10.1007/s12035-017-0538-y
   Aslani S, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.178
   Baker KD, 2017, NEUROSCI BIOBEHAV R, V83, P173, DOI 10.1016/j.neubiorev.2017.10.014
   Batschauer T, 2020, PHYSIOL BEHAV, V223, DOI 10.1016/j.physbeh.2020.113013
   Beaulieu JM, 2008, P NATL ACAD SCI USA, V105, P1333, DOI 10.1073/pnas.0711496105
   Blaisdell AP, 2014, PHYSIOL BEHAV, V128, P220, DOI 10.1016/j.physbeh.2014.02.025
   Blüher M, 2019, NAT REV ENDOCRINOL, V15, P288, DOI 10.1038/s41574-019-0176-8
   Bridgewater LC, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-11069-4
   Bruce-Keller AJ, 2015, BIOL PSYCHIAT, V77, P607, DOI 10.1016/j.biopsych.2014.07.012
   Choudhary P, 2018, METAB BRAIN DIS, V33, P1563, DOI 10.1007/s11011-018-0263-x
   Chuang JC, 2010, BIOL PSYCHIAT, V67, P1075, DOI 10.1016/j.biopsych.2009.12.003
   Chudasama HP, 2009, CAN J PHYSIOL PHARM, V87, P900, DOI [10.1139/Y09-080, 10.1139/y09-080]
   Craske MG, 2016, LANCET, V388, P3048, DOI 10.1016/S0140-6736(16)30381-6
   Cryan JF, 2005, NAT REV DRUG DISCOV, V4, P775, DOI 10.1038/nrd1825
   Cryan JF, 2020, LANCET NEUROL, V19, P179, DOI 10.1016/S1474-4422(19)30356-4
   Dallman MF, 2010, TRENDS ENDOCRIN MET, V21, P159, DOI 10.1016/j.tem.2009.10.004
   de Noronha SR, 2017, BEHAV BRAIN RES, V316, P38, DOI 10.1016/j.bbr.2016.08.042
   Del Rio D, 2016, BEHAV BRAIN RES, V311, P167, DOI 10.1016/j.bbr.2016.04.052
   Del Rosario A, 2012, BRIT J NUTR, V108, P1143, DOI 10.1017/S0007114511006738
   Dutheil S, 2016, NEUROPSYCHOPHARMACOL, V41, P1874, DOI 10.1038/npp.2015.357
   Eagle A., 2016, Bio-Protocol, V6, P1, DOI DOI 10.21769/BIOPROTOC.1822
   Enge S, 2016, FRONT HUM NEUROSCI, V10, DOI 10.3389/fnhum.2016.00370
   Eslam M, 2020, GASTROENTEROLOGY, V158, P1999, DOI 10.1053/j.gastro.2019.11.312
   Eslamparast T, 2017, NUTRIENTS, V9, DOI 10.3390/nu9080800
   Fakhfouri G, 2019, PHARMACOL REV, V71, P383, DOI 10.1124/pr.118.015487
   Feng MY, 2019, NEUROSCIENCE, V406, P109, DOI 10.1016/j.neuroscience.2019.03.003
   Fernandez F, 2004, NEUROPSYCHOPHARMACOL, V29, P59, DOI 10.1038/sj.npp.1300308
   File SE, 2003, EUR J PHARMACOL, V463, P35, DOI 10.1016/S0014-2999(03)01273-1
   Finger BC, 2011, NEUROSCIENCE, V192, P351, DOI 10.1016/j.neuroscience.2011.06.072
   Gainey SJ, 2016, FRONT BEHAV NEUROSCI, V10, DOI 10.3389/fnbeh.2016.00156
   Gancheva S, 2017, INT J EXP PATHOL, V98, P296, DOI 10.1111/iep.12254
   Ganji A, 2017, METAB BRAIN DIS, V32, P503, DOI 10.1007/s11011-016-9940-9
   Gibson EL, 2006, PHYSIOL BEHAV, V89, P53, DOI 10.1016/j.physbeh.2006.01.024
   Gururajan A, 2019, NAT REV NEUROSCI, V20, P686, DOI 10.1038/s41583-019-0221-6
   Hariri N, 2010, NUTR RES REV, V23, P270, DOI 10.1017/S0954422410000168
   Hassan AM, 2019, NUTR NEUROSCI, V22, P877, DOI 10.1080/1028415X.2018.1465713
   Higarza SG, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0223019
   Hintze KJ, 2018, ADV NUTR, V9, P263, DOI 10.1093/advances/nmy002
   Hollander JA, 2020, NEUROPSYCHOPHARMACOL, V45, P1086, DOI 10.1038/s41386-020-0648-5
   Hoyer D, 2002, PHARMACOL BIOCHEM BE, V71, P533, DOI 10.1016/S0091-3057(01)00746-8
   Hu Hua, 2014, Shanghai Arch Psychiatry, V26, P129, DOI 10.3969/j.issn.1002-0829.2014.03.004
   [黄英杰 Huang Yingjie], 2019, [中国药物依赖性杂志, Chinese Journal of Drug Dependence], V28, P426
   Jacobsen JPR, 2012, MOL PSYCHIATR, V17, P694, DOI 10.1038/mp.2011.50
   Jacobson LH, 2007, BEHAV GENET, V37, P171, DOI 10.1007/s10519-006-9106-3
   Jebeile H, 2019, JAMA PEDIATR, V173, DOI 10.1001/jamapediatrics.2019.2841
   Ji SQ, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00704
   Jorgensen BP, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0103398
   Jung JY, 2019, J KOREAN MED SCI, V34, DOI 10.3346/jkms.2019.34.e199
   Kaczmarczyk MM, 2013, PSYCHONEUROENDOCRINO, V38, P1553, DOI 10.1016/j.psyneuen.2013.01.004
   Karth MM, 2019, FRONT MOL NEUROSCI, V12, DOI 10.3389/fnmol.2019.00298
   Kessler RC, 2005, ARCH GEN PSYCHIAT, V62, P593, DOI 10.1001/archpsyc.62.6.593
   Khedr SA, 2018, N-S ARCH PHARMACOL, V391, P407, DOI 10.1007/s00210-018-1466-8
   Kim D, 2019, ALIMENT PHARM THER, V50, P590, DOI 10.1111/apt.15395
   Kurhe Y, 2017, INDIAN J PHARMACOL, V49, P290, DOI 10.4103/ijp.IJP_805_16
   Kurhe Y, 2017, PSYCHOPHARMACOLOGY, V234, P1165, DOI 10.1007/s00213-017-4558-0
   Kurhe Y, 2015, PHARMACOL BIOCHEM BE, V136, P107, DOI 10.1016/j.pbb.2015.07.004
   Kurhe Y, 2015, BIOCHEM BIOPH RES CO, V456, P74, DOI 10.1016/j.bbrc.2014.11.036
   Lamers F, 2019, EUR NEUROPSYCHOPHARM, V29, pS2, DOI 10.1016/j.euroneuro.2019.09.022
   Leite F, 2018, PSYCHOL MED, V48, P2273, DOI 10.1017/S0033291718001587
   Liu WN, 2016, PSYCHOSOM MED, V78, P102, DOI 10.1097/PSY.0000000000000268
   Liu WN, 2014, J AFFECT DISORDERS, V156, P171, DOI 10.1016/j.jad.2013.11.025
   Magdy YM, 2017, BIOMED PHARMACOTHER, V85, P225, DOI 10.1016/j.biopha.2016.10.098
   Masood A, 2008, J PHARMACOL EXP THER, V326, P369, DOI 10.1124/jpet.108.137208
   Metwally FM, 2019, PHYSIOL BEHAV, V201, P1, DOI 10.1016/j.physbeh.2018.12.010
   Mullins N, 2019, AM J PSYCHIAT, V176, P651, DOI 10.1176/appi.ajp.2019.18080957
   Murphy EA, 2015, CURR OPIN CLIN NUTR, V18, P515, DOI 10.1097/MCO.0000000000000209
   Murray CJL, 1997, LANCET, V349, P1498, DOI 10.1016/S0140-6736(96)07492-2
   Nakajima S, 2020, INT J OBESITY, V44, P727, DOI 10.1038/s41366-019-0468-z
   Nelson EE, 2009, NEUROPSYCHOPHARMACOL, V34, P90, DOI 10.1038/npp.2008.150
   Ogrodnik M, 2019, CELL METAB, V29, P1061, DOI [10.1016/j.cmet.2018.12.008, 10.1016/j.cmet.2019.01.013]
   Oliver G, 1999, PHYSIOL BEHAV, V66, P511, DOI 10.1016/S0031-9384(98)00322-9
   Otsuka A, 2019, LIFE SCI, V219, P219, DOI 10.1016/j.lfs.2019.01.012
   OVERSTREET DH, 1982, PSYCHOPHARMACOLOGY, V78, P150, DOI 10.1007/BF00432254
   Overstreet DH, 2005, NEUROSCI BIOBEHAV R, V29, P739, DOI 10.1016/j.neubiorev.2005.03.015
   Pan Q, 2019, METAB BRAIN DIS, V34, P747, DOI 10.1007/s11011-019-0392-x
   Park HS, 2017, PSYCHIAT RES, V250, P71, DOI 10.1016/j.psychres.2017.01.012
   Peris-Sampedro F, 2019, OBESITY, V27, P409, DOI 10.1002/oby.22381
   Petit-Demouliere B, 2005, PSYCHOPHARMACOLOGY, V177, P245, DOI 10.1007/s00213-004-2048-7
   Rebolledo-Solleiro D, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0176554
   Roy T, 2012, J AFFECT DISORDERS, V142, pS8, DOI 10.1016/S0165-0327(12)70004-6
   Salk RH, 2017, PSYCHOL BULL, V143, P783, DOI 10.1037/bul0000102
   Sandhu KV, 2017, TRANSL RES, V179, P223, DOI 10.1016/j.trsl.2016.10.002
   Santhekadur PK, 2018, J HEPATOL, V68, P230, DOI 10.1016/j.jhep.2017.10.031
   Sarwar N, 2010, LANCET, V375, P2215, DOI 10.1016/s0140-6736(10)60484-9
   Schmitz N, 2016, MOL PSYCHIATR, V21, P1726, DOI 10.1038/mp.2016.7
   Semenkovich K, 2015, DRUGS, V75, P577, DOI 10.1007/s40265-015-0347-4
   Sharma S, 2013, INT J OBESITY, V37, P382, DOI 10.1038/ijo.2012.48
   Sherwin E, 2018, ANN NY ACAD SCI, V1420, P5, DOI 10.1111/nyas.13416
   Simpson H.B., 2010, Anxiety disorders: Theory, research and clinical perspectives
   Soto M, 2018, MOL PSYCHIATR, V23, P2287, DOI 10.1038/s41380-018-0086-5
   STERU L, 1985, PSYCHOPHARMACOLOGY, V85, P367, DOI 10.1007/BF00428203
   Strekalova T, 2016, J AFFECT DISORDERS, V196, P109, DOI 10.1016/j.jad.2016.02.045
   Strekalova T, 2015, BRAIN BEHAV IMMUN, V48, P42, DOI 10.1016/j.bbi.2015.02.015
   Suárez J, 2019, PSYCHONEUROENDOCRINO, V110, DOI 10.1016/j.psyneuen.2019.104418
   Sullivan EL, 2014, PHYSIOL BEHAV, V123, P236, DOI 10.1016/j.physbeh.2012.07.014
   Sumaya IC, 2016, PHARMACOL BIOCHEM BE, V144, P78, DOI 10.1016/j.pbb.2016.03.005
   Sweeney P, 2017, INT J OBESITY, V41, P1237, DOI 10.1038/ijo.2017.112
   Takao Keizo, 2006, J Vis Exp, P104, DOI 10.3791/104
   Tomiga Y, 2019, J PHYSIOL SCI, V69, P711, DOI 10.1007/s12576-019-00686-5
   Tomiga Y, 2017, NITRIC OXIDE-BIOL CH, V66, P71, DOI 10.1016/j.niox.2017.03.002
   Tsai SF, 2018, BRAIN RES, V1700, P66, DOI 10.1016/j.brainres.2018.07.017
   Vagena E, 2019, TRANSL PSYCHIAT, V9, DOI 10.1038/s41398-019-0470-1
   Valles-Colomer M, 2019, NAT MICROBIOL, V4, P623, DOI 10.1038/s41564-018-0337-x
   Vancampfort D, 2016, WORLD PSYCHIATRY, V15, P166, DOI 10.1002/wps.20309
   Vogelzangs N, 2011, J CLIN PSYCHIAT, V72, P598, DOI 10.4088/JCP.10m06559
   Walf AA, 2007, NAT PROTOC, V2, P322, DOI 10.1038/nprot.2007.44
   Weihong X, 2019, TOXICOLOGY, V414, P27, DOI 10.1016/j.tox.2019.01.003
   Willebrords J, 2015, PROG LIPID RES, V59, P106, DOI 10.1016/j.plipres.2015.05.002
   WILLNER P, 1987, PSYCHOPHARMACOLOGY, V93, P358
   Willner P, 1997, PSYCHOPHARMACOLOGY, V134, P319, DOI 10.1007/s002130050456
   Wong CH, 2019, BIOSTATISTICS, V20, P366, DOI 10.1093/biostatistics/kxy072
   Wong SK, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0123-9
   Wu FF, 2020, ANAEROBE, V61, DOI 10.1016/j.anaerobe.2019.102138
   Wu HL, 2019, J AFFECT DISORDERS, V243, P83, DOI 10.1016/j.jad.2018.09.022
   Wu HL, 2018, METAB BRAIN DIS, V33, P177, DOI 10.1007/s11011-017-0140-z
   Xu L, 2018, NEUROSCIENCE, V372, P237, DOI 10.1016/j.neuroscience.2018.01.001
   Yamada N, 2011, ENDOCRINOLOGY, V152, P2634, DOI 10.1210/en.2011-0004
   Yang JL, 2016, SCI REP-UK, V6, DOI 10.1038/srep35239
   Younossi Z, 2018, NAT REV GASTRO HEPAT, V15, P11, DOI 10.1038/nrgastro.2017.109
   Zemdegs J, 2019, J NEUROSCI, V39, P5935, DOI 10.1523/JNEUROSCI.2904-18.2019
   Zemdegs J, 2016, BRIT J PHARMACOL, V173, P2095, DOI 10.1111/bph.13343
   Zheng Y, 2018, NAT REV ENDOCRINOL, V14, P88, DOI 10.1038/nrendo.2017.151
NR 133
TC 12
Z9 14
U1 3
U2 34
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD DEC 28
PY 2021
VL 126
IS 12
BP 1771
EP 1787
AR PII S0007114521000659
DI 10.1017/S0007114521000659
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA WX0TV
UT WOS:000718318500004
PM 33618780
DA 2025-06-11
ER

PT J
AU Sato, AF
   Fahrenkamp, AJ
AF Sato, Amy F.
   Fahrenkamp, Amy J.
TI From Bench to Bedside Understanding Stress-Obesity Research Within the
   Context of Translation to Improve Pediatric Behavioral Weight Management
SO PEDIATRIC CLINICS OF NORTH AMERICA
LA English
DT Article
DE Obesity; Stress; Weight management; Adolescents; Translational research;
   Mindfulness
ID MINDFULNESS-BASED INTERVENTION; BODY-MASS INDEX; EATING BEHAVIOR;
   PHYSICAL-ACTIVITY; PSYCHOLOGICAL STRESS; CORTISOL REACTIVITY; OVERWEIGHT
   CHILDREN; METABOLIC SYNDROME; DIETARY RESTRAINT; PERCEIVED STRESS
AB A growing body of literature suggests that stress, including chronic stress and acute physiologic stress reactivity, is one contributor to the development and maintenance of obesity in youth. Little has been done to apply the literature on stress and obesity risk to inform the development of pediatric behavioral weight control (BWC) interventions. The aims of this review are to (1) discuss research linking stress and pediatric obesity, (2) provide examples of the implications of the stress-obesity research for pediatric BWC development, and (3) propose that a mindfulness-based approach may be useful in targeting stress reduction within pediatric BWC.
C1 [Sato, Amy F.; Fahrenkamp, Amy J.] Kent State Univ, Dept Psychol Sci, 600 Hilltop Dr, Kent, OH 44242 USA.
C3 University System of Ohio; Kent State University; Kent State University
   Salem; Kent State University Kent
RP Sato, AF (corresponding author), Kent State Univ, Dept Psychol Sci, 600 Hilltop Dr, Kent, OH 44242 USA.
EM asato2@kent.edu
RI Sato, Amy/K-7916-2018
CR Adam TC, 2007, PHYSIOL BEHAV, V91, P449, DOI 10.1016/j.physbeh.2007.04.011
   Adam TC, 2010, J CLIN ENDOCR METAB, V95, P4729, DOI 10.1210/jc.2010-0322
   Alberts HJEM, 2012, APPETITE, V58, P847, DOI 10.1016/j.appet.2012.01.009
   [Anonymous], 2003, MED SCI MONIT
   [Anonymous], 1990, FULL CATASTROPHE LIV, DOI DOI 10.1037/032287
   Baer RA, 2014, PRACT RESOUR MENT, P3, DOI 10.1016/B978-0-12-416031-6.00001-3
   Balantekin KN, 2012, APPETITE, V59, P298, DOI 10.1016/j.appet.2012.05.016
   Barnes VA, 1998, INT J OBESITY, V29, P997
   Baxter KA, 2013, OBES RES CLIN PRACT, V7, pE147, DOI 10.1016/j.orcp.2011.09.004
   Biegel GM, 2009, J CONSULT CLIN PSYCH, V77, P855, DOI 10.1037/a0016241
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   Björntorp P, 2000, NUTRITION, V16, P924, DOI 10.1016/S0899-9007(00)00422-6
   Block JP, 2009, AM J EPIDEMIOL, V170, P181, DOI 10.1093/aje/kwp104
   Brambilla P, 2013, INT J OBESITY, V37, P943, DOI 10.1038/ijo.2013.32
   Bronfenbrenner U., 1989, Six Theories of Child Development: Revised Formulations and Current Issues, P187
   Burke NJ, 2011, CHILD ABUSE NEGLECT, V35, P408, DOI 10.1016/j.chiabu.2011.02.006
   Corsica J, 2014, EAT BEHAV, V15, P694, DOI 10.1016/j.eatbeh.2014.08.002
   Crawford PB, 2011, AM J PREV MED, V40, P274, DOI 10.1016/j.amepre.2010.11.003
   Daddis C, 2011, CHILD DEV, V82, P1310, DOI 10.1111/j.1467-8624.2011.01587.x
   Dalen J, 2010, COMPLEMENT THER MED, V18, P260, DOI 10.1016/j.ctim.2010.09.008
   Dallman MF, 2010, TRENDS ENDOCRIN MET, V21, P159, DOI 10.1016/j.tem.2009.10.004
   Dallman MF, 2003, P NATL ACAD SCI USA, V100, P11696, DOI 10.1073/pnas.1934666100
   Daubenmier J, 2011, J OBES, V2011, DOI 10.1155/2011/651936
   De Vriendt T, 2009, NUTR METAB CARDIOVAS, V19, P511, DOI 10.1016/j.numecd.2009.02.009
   Di Noia J, 2013, NUTR REV, V71, P224, DOI 10.1111/nure.12009
   Dockray S, 2009, J ADOLESCENT HEALTH, V45, P344, DOI 10.1016/j.jadohealth.2009.06.014
   Drapeau V, 2001, PANMINERVA MED, V43, P1
   Edwards M, 2014, J SPEC GROUP WORK, V39, P145, DOI 10.1080/01933922.2014.891683
   Epel E, 2001, PSYCHONEUROENDOCRINO, V26, P37, DOI 10.1016/S0306-4530(00)00035-4
   Epel ES, 2000, PSYCHOSOM MED, V62, P623, DOI 10.1097/00006842-200009000-00005
   Faith MS, 1995, OVERWEIGHT WEIGHT MA, P439
   Francis LA, 2013, APPETITE, V64, P32, DOI 10.1016/j.appet.2012.11.008
   Garasky S, 2009, SOC SCI RES, V38, P755, DOI 10.1016/j.ssresearch.2009.06.002
   Goldbacher EM, 2005, HEALTH PSYCHOL, V24, P375, DOI 10.1037/0278-6133.24.4.375
   Goodman E, 2005, J ADOLESCENT HEALTH, V37, P484, DOI 10.1016/j.jadohealth.2004.11.126
   Greenberg MT, 2012, CHILD DEV PERSPECT, V6, P161, DOI 10.1111/j.1750-8606.2011.00215.x
   GREENO CG, 1994, PSYCHOL BULL, V115, P444, DOI 10.1037/0033-2909.115.3.444
   Gundersen C, 2011, OBES REV, V12, pe54, DOI 10.1111/j.1467-789X.2010.00813.x
   Gunnar M, 2007, ANNU REV PSYCHOL, V58, P145, DOI 10.1146/annurev.psych.58.110405.085605
   Hayden-Wade HA, 2005, OBES RES, V13, P1381, DOI 10.1038/oby.2005.167
   Hayes S. C., 1999, Acceptance and commitment therapy: An experiential approach to behavior change
   Hearst MO, 2012, HEALTH EDUC BEHAV, V39, P446, DOI 10.1177/1090198111426453
   Herman CP, 1999, APPETITE, V33, P181, DOI 10.1006/appe.1999.0243
   Horsch A, 2015, BMC PEDIATR, V15, DOI 10.1186/s12887-015-0326-7
   Janicke DM, 2008, ARCH PEDIAT ADOL MED, V162, P1119, DOI 10.1001/archpedi.162.12.1119
   Kearney DJ, 2012, NUTR RES, V32, P413, DOI 10.1016/j.nutres.2012.05.008
   Kendzor DE, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-611
   KIRSCHBAUM C, 1993, NEUROPSYCHOBIOLOGY, V28, P76, DOI 10.1159/000119004
   Kirschenbaum DS, 2005, OBES RES, V13, P1527, DOI 10.1038/oby.2005.187
   Koch FS, 2008, J PEDIATR-US, V153, P839, DOI 10.1016/j.jpeds.2008.06.016
   Kristeller J L, 1999, J Health Psychol, V4, P357, DOI 10.1177/135910539900400305
   Kristeller J, 2014, MINDFULNESS, V5, P282, DOI 10.1007/s12671-012-0179-1
   Linehan M, 2008, CLIN HDB PSYCHOL DIS, P394
   Lu QY, 2014, APPETITE, V72, P13, DOI 10.1016/j.appet.2013.09.019
   Lumeng JC, 2006, ARCH PEDIAT ADOL MED, V160, P25, DOI 10.1001/archpedi.160.1.25
   Maayan L, 2011, OBESITY, V19, P1382, DOI 10.1038/oby.2011.15
   Manzoni GM, 2009, J AM DIET ASSOC, V109, P1427, DOI 10.1016/j.jada.2009.05.004
   MELLBIN T, 1989, ACTA PAEDIATR SCAND, V78, P568, DOI 10.1111/j.1651-2227.1989.tb17938.x
   Mellin AE, 2002, J ADOLESCENT HEALTH, V31, P145, DOI 10.1016/S1054-139X(01)00396-2
   Michels N, 2012, APPETITE, V59, P762, DOI 10.1016/j.appet.2012.08.010
   Miller CK, 2014, HEALTH EDUC BEHAV, V41, P145, DOI 10.1177/1090198113493092
   Miller CK, 2012, J ACAD NUTR DIET, V112, P1835, DOI 10.1016/j.jand.2012.07.036
   Newman E, 2007, PSYCHONEUROENDOCRINO, V32, P125, DOI 10.1016/j.psyneuen.2006.11.006
   Nguyen-Rodriguez Selena T, 2008, Eat Behav, V9, P238, DOI 10.1016/j.eatbeh.2007.09.001
   Ogden CL, 2012, JAMA-J AM MED ASSOC, V307, P483, DOI [10.1001/jama.2012.39, 10.1001/jama.2012.40]
   Oliver G, 2000, PSYCHOSOM MED, V62, P853, DOI 10.1097/00006842-200011000-00016
   Olson KL, 2015, PSYCHOSOM MED, V77, P59, DOI 10.1097/PSY.0000000000000127
   Oude Luttikhuis H, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001872.pub2
   Ozier AD, 2008, J AM DIET ASSOC, V108, P49, DOI 10.1016/j.jada.2007.10.011
   Park AE, 2015, INT J PSYCHOPHYSIOL, V97, P139, DOI 10.1016/j.ijpsycho.2015.05.016
   Pervanidou P, 2012, METABOLISM, V61, P611, DOI 10.1016/j.metabol.2011.10.005
   Pieper JR, 2013, APPETITE, V62, P103, DOI 10.1016/j.appet.2012.11.020
   Raspopow K, 2010, HORM BEHAV, V58, P677, DOI 10.1016/j.yhbeh.2010.06.003
   Rodriguez ACI, 2015, PSYCHONEUROENDOCRINO, V62, P301, DOI 10.1016/j.psyneuen.2015.08.014
   Roemmich JN, 2007, OBESITY, V15, P2303, DOI 10.1038/oby.2007.273
   Roemmich JN, 2011, EAT BEHAV, V12, P309, DOI 10.1016/j.eatbeh.2011.07.003
   Roemmich JN, 2003, OBES RES, V11, P1080, DOI 10.1038/oby.2003.148
   Roemmich JN, 2002, OBES RES, V10, P1120, DOI 10.1038/oby.2002.152
   Rogers PJ, 2000, PHARMACOL BIOCHEM BE, V66, P3, DOI 10.1016/S0091-3057(00)00197-0
   Sibinga EMS, 2011, J ALTERN COMPLEM MED, V17, P213, DOI 10.1089/acm.2009.0605
   Skouteris H, 2012, EARLY CHILD DEV CARE, V182, P153, DOI 10.1080/03004430.2010.548606
   Smith BW, 2006, J EVID-BASED INTEGR, V11, P133, DOI 10.1177/1533210106297217
   Thayer R.E., 2001, Calm energy: How people regulate mood with food and exercise
   Thompson Miles, 2008, Clin Child Psychol Psychiatry, V13, P395, DOI 10.1177/1359104508090603
   Tomiyama AJ, 2011, PSYCHONEUROENDOCRINO, V36, P1513, DOI 10.1016/j.psyneuen.2011.04.005
   van Jaarsveld CHM, 2009, OBESITY, V17, P2155, DOI 10.1038/oby.2009.183
   Ver Ploeg M., 2009, ACCESS AFFORDABLE NU, P1
   Verdejo-Garcia A, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0123565
   Weigensberg MJ, 2008, J CLIN ENDOCR METAB, V93, P1372, DOI 10.1210/jc.2007-2309
   Weiss R, 2004, NEW ENGL J MED, V350, P2362, DOI 10.1056/NEJMoa031049
   Wilson SM, 2014, STRESS HEALTH, V30, P91, DOI 10.1002/smi.2501
   Wright LB, 2011, J BLACK PSYCHOL, V37, P210, DOI 10.1177/0095798410380203
   Yin ZN, 2005, ANN BEHAV MED, V29, P29, DOI 10.1207/s15324796abm2901_5
   Zeller MH, 2006, PEDIATRICS, V117, P1155, DOI 10.1542/peds.2005-1141
   Zoogman S, 2015, MINDFULNESS, V6, P290, DOI 10.1007/s12671-013-0260-4
NR 95
TC 4
Z9 5
U1 2
U2 15
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0031-3955
EI 1557-8240
J9 PEDIATR CLIN N AM
JI Pediatr. Clin. N. Am.
PD JUN
PY 2016
VL 63
IS 3
BP 401
EP +
DI 10.1016/j.pcl.2016.02.003
PG 24
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA DP9OB
UT WOS:000378824600005
PM 27261542
DA 2025-06-11
ER

PT J
AU Fibbins, H
   Ward, PB
   Watkins, A
   Curtis, J
   Rosenbaum, S
AF Fibbins, Hamish
   Ward, Philip B.
   Watkins, Andrew
   Curtis, Jackie
   Rosenbaum, Simon
TI Improving the health of mental health staff through exercise
   interventions: a systematic review
SO JOURNAL OF MENTAL HEALTH
LA English
DT Review
DE Exercise; mental illness; psychiatry; systematic review; inpatient;
   staff
ID PHYSICAL HEALTH; LIFE-STYLE; CARDIOVASCULAR-DISEASE; SMOKING-CESSATION;
   PEOPLE; ILLNESS; METAANALYSIS; MORTALITY; SCHIZOPHRENIA; DISORDERS
AB Background: Exercise interventions are efficacious in reducing cardiometabolic risk and improving symptoms in people with severe mental illness, yet evidence guiding the implementation and scalability of such efforts is lacking. Given increasing efforts to address the disparity in physical health outcomes facing people with a mental illness, novel approaches to increasing adoption of effective interventions are required. Exercise interventions targeting mental health staff may improve staff health while also creating more positive attitudes towards the role of lifestyle interventions for people experiencing mental illness.Aims: We aimed to determine the feasibility, acceptability and effectiveness of exercise interventions delivered to staff working in mental health services.Method: A systematic review was conducted from database inception, until November 2017. Studies recruiting staff participants to receive an exercise intervention were eligible for inclusion.Results: Five studies met the inclusion criteria. Physical health interventions for mental health staff were feasible and acceptable with low dropout rates. Reductions in anthropometric measures and work-related stress were reported.Conclusions: Limited evidence suggests that exercise interventions targeting mental health staff are feasible and acceptable. Further research is required to determine the efficacy of such interventions and the impact such strategies may have on staff culture and patient outcomes.
C1 [Fibbins, Hamish; Watkins, Andrew; Curtis, Jackie] South Eastern Sydney Local Hlth Dist, Keeping Body Mind Program, Sydney, NSW, Australia.
   [Fibbins, Hamish; Ward, Philip B.; Curtis, Jackie; Rosenbaum, Simon] Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia.
   [Ward, Philip B.] South Western Sydney Local Hlth Dist, Schizophrenia Res Unit, Sydney, NSW, Australia.
   [Ward, Philip B.] Ingham Inst Appl Med Res, Liverpool, NSW, Australia.
   [Watkins, Andrew] Univ Technol, Fac Hlth, Sydney, NSW, Australia.
   [Rosenbaum, Simon] Black Dog Inst, Randwick, NSW, Australia.
C3 South Eastern Sydney Local Health District; University of New South
   Wales Sydney; South Western Sydney Local Health District; Ingham
   Institute for Applied Medical Research; University of Technology Sydney;
   Black Dog Institute
RP Fibbins, H (corresponding author), Univ New South Wales, Sydney, NSW, Australia.
EM hamish.fibbins@health.nsw.gov.au
RI Curtis, Jackie/J-5789-2019; Fibbins, Hamish/KLZ-4932-2024; Rosenbaum,
   Simon/Y-3241-2019; Ward, Philip/JCE-6293-2023
OI Rosenbaum, Simon/0000-0002-8984-4941; Watkins,
   Andrew/0000-0003-3452-8682; Ward, Philip/0000-0002-5779-7722; Fibbins,
   Hamish/0000-0002-2673-7866; Curtis, Jackie/0000-0001-6884-0098
CR Alvarez-Jiménez M, 2008, CNS DRUGS, V22, P547, DOI 10.2165/00023210-200822070-00002
   [Anonymous], JAMA
   [Anonymous], 2015, IMPLEMENT SCI, DOI DOI 10.1186/1748-5908-10-S1-A15
   [Anonymous], SCHIZOPHRENIA BULL
   [Anonymous], THESIS
   [Anonymous], 2008, Physical activity in the workplace
   Aschbrenner KA, 2015, J NERV MENT DIS, V203, P473, DOI 10.1097/NMD.0000000000000309
   Aschbrenner KA, 2013, PSYCHIATR REHABIL J, V36, P65, DOI 10.1037/h0094973
   Barry VW, 2014, PROG CARDIOVASC DIS, V56, P382, DOI 10.1016/j.pcad.2013.09.002
   Camann MA, 2001, ARCH PSYCHIAT NURS, V15, P182, DOI 10.1053/apnu.2001.25418
   Cleary M, 2005, INT J MENT HEALTH NU, V14, P32, DOI 10.1111/j.1440-0979.2005.00352.x
   Conroy RM, 2003, EUR HEART J, V24, P987, DOI 10.1016/S0195-668X(03)00114-3
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   DEWE P, 1991, J OCCUP PSYCHOL, V64, P331, DOI 10.1111/j.2044-8325.1991.tb00564.x
   Fie S, 2013, HEALTH EDUC J, V72, P102, DOI 10.1177/0017896911430763
   Firth J, 2015, PSYCHOL MED, V45, P1343, DOI 10.1017/S0033291714003110
   Firth J, 2017, SCHIZOPHRENIA BULL, V43, P546, DOI 10.1093/schbul/sbw115
   Forsberg KA, 2008, NORD J PSYCHIAT, V62, P486, DOI 10.1080/08039480801985179
   Gilbody S, 2015, LANCET PSYCHIAT, V2, P395, DOI 10.1016/S2215-0366(15)00091-7
   Gosfield Alice G, 2008, Physician Exec, V34, P26
   Haines DJ, 2007, J AM COLL HEALTH, V55, P219, DOI 10.3200/JACH.55.4.219-225
   Hjorth P, 2016, NORD J PSYCHIAT, V70, P62, DOI 10.3109/08039488.2015.1050452
   Hjorthoj C, 2017, LANCET PSYCHIAT, V4, P295, DOI 10.1016/S2215-0366(17)30078-0
   Howard L, 2011, J PSYCHIATR MENT HLT, V18, P105, DOI 10.1111/j.1365-2850.2010.01642.x
   Hyland B, 2003, AUST NZ J PSYCHIAT, V37, P710, DOI 10.1111/j.1440-1614.2003.01264.x
   Lin SL, 2015, WORLDV EVID-BASED NU, V12, P236, DOI 10.1111/wvn.12097
   Maher CG, 2003, PHYS THER, V83, P713, DOI 10.1093/ptj/83.8.713
   Mitchell AJ, 2015, GEN HOSP PSYCHIAT, V37, P14, DOI 10.1016/j.genhosppsych.2014.11.006
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Olfson M, 2015, JAMA PSYCHIAT, V72, P1172, DOI 10.1001/jamapsychiatry.2015.1737
   Organ B, 2010, AUSTRALAS PSYCHIATRY, V18, P456, DOI 10.3109/10398562.2010.506217
   Rosenbaum S, 2016, AUST NZ J PSYCHIAT, V50, P600, DOI 10.1177/0004867415620023
   Schuch F, 2017, J AFFECT DISORDERS, V210, P139, DOI 10.1016/j.jad.2016.10.050
   Shiers D, 2014, LANCET PSYCHIAT, V1, P492, DOI 10.1016/S2215-0366(14)00072-8
   Stewart R, 2015, ACTA PSYCHIAT SCAND, V132, P410, DOI 10.1111/acps.12476
   Stubbs B, 2017, SCHIZOPHRENIA BULL, V43, P536, DOI 10.1093/schbul/sbw111
   Stubbs B, 2016, J AFFECT DISORDERS, V190, P457, DOI 10.1016/j.jad.2015.10.019
   Suetani S, 2015, JAMA PSYCHIAT, V72, P1166, DOI 10.1001/jamapsychiatry.2015.1981
   Taggart H, 2015, BRIT J PSYCHIAT, V207, P469, DOI 10.1192/bjp.bp.115.167759
   Teasdale SB, 2017, BRIT J PSYCHIAT, V210, P110, DOI 10.1192/bjp.bp.115.177139
   Teasdale SB, 2016, BRIT J NUTR, V115, P1987, DOI 10.1017/S0007114516001033
   Terry J, 2013, ISSUES MENT HEALTH N, V34, P249, DOI 10.3109/01612840.2012.740768
   Tucker S, 2016, WORKPLACE HEALTH SAF, V64, P313, DOI 10.1177/2165079916633225
   Vancampfort D, 2016, GEN HOSP PSYCHIAT, V39, P15, DOI 10.1016/j.genhosppsych.2015.11.008
   Vancampfort D, 2015, SCHIZOPHR RES, V169, P453, DOI 10.1016/j.schres.2015.09.029
   Verhagen AP, 1998, J CLIN EPIDEMIOL, V51, P1235, DOI 10.1016/S0895-4356(98)00131-0
   Watkins A, 2017, FRONT PUBLIC HEALTH, V5, DOI 10.3389/fpubh.2017.00321
NR 47
TC 24
Z9 26
U1 1
U2 51
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0963-8237
EI 1360-0567
J9 J MENT HEALTH
JI J. Ment. Heal.
PY 2018
VL 27
IS 2
BP 184
EP 191
DI 10.1080/09638237.2018.1437614
PG 8
WC Psychology, Clinical; Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA FX5GT
UT WOS:000426106800013
PM 29447044
DA 2025-06-11
ER

PT J
AU Liu, JZ
   Yang, YL
   Zhang, YJ
   Wang, HF
   Wei, WJ
   Lang, XE
   Zhang, XY
AF Liu, Jizhou
   Yang, Yonglan
   Zhang, Yanjiang
   Wang, Haifeng
   Wei, Wenjian
   Lang, Xiaoe
   Zhang, Xiangyang
TI Prevalence and risk factors of anxiety symptoms in first-episode and
   drug-naïve major depressive disorder patients with metabolic syndrome
SO EUROPEAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Anxiety symptoms; Major depressive disorder; First episode and drug
   naive (FEDN); Metabolic syndrome; Risk factor
ID ANXIOUS DEPRESSION; COMORBID ANXIETY; METAANALYSIS; HYPERTENSION;
   ASSOCIATION; CHINA
AB Background and objectives: Patients with major depressive disorder (MDD) have high comorbidity with metabolic syndrome (MetS), although anxiety is prevalent comorbidity in MDD patients. However, there is no study on anxiety symptoms (AS) in MDD patients with MetS. Therefore, we aimed to identify the prevalence and risk factors of AS in patients with MetS who experienced a first-episode and drug naive (FEDN) of MDD. Methods: In this cross-sectional study, 1718 FEDN of MDD outpatients with MetS were included. Sociodemographic data, clinical characteristics, suicidal attempts, and physical and biochemical parameters were collected. Hamilton Anxiety Rating Scale (HAMA), Hamilton Depression Rating Scale (HAMD), and Positive and Negative Syndrome Scale (PANSS) positive subscale were performed to detect the AS. Multiple linear regression analysis was used to analyze the correlation. Results: The prevalence of AS in MDD patients with MetS was 85.96%, which was 1.79 times greater than that in patients with MDD alone (P<0.05). MDD patients with MetS had a greater rate of attempted suicide, a higher HAMD total score, and a higher diastolic blood pressure than MDD patients without AS (P<0.05). Their combination could distinguish AS in MDD patients. Moreover, HAMD score, thyroid-stimulating hormone (TSH) levels, PANSS positive score, and suicide attempts were related to HAMA scores in MDD patients with comorbid MetS (P<0.05). Conclusion: There is a significant frequency of AS in MDD patients with MetS. Multiple clinical indicators and metabolic markers are associated with AS in patients with MDD and MetS. (c) 2023 The Authors. Published by Elsevier Espana, S.L.U. on behalf of Sociedad Espanola de Psiquiatria y Salud Mental.
C1 [Liu, Jizhou; Yang, Yonglan; Zhang, Yanjiang; Wang, Haifeng; Wei, Wenjian] 2nd Peoples Hosp Honghe Hani & Yi Autonomous Prefe, Dept Clin Psychol, Jianshui 654399, Peoples R China.
   [Lang, Xiaoe] Shanxi Med Univ, Hosp 1, Dept Psychiat, Clin Med Coll 1, Taiyuan 030000, Peoples R China.
   [Zhang, Xiangyang] Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China.
   [Zhang, Xiangyang] Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China.
   [Zhang, Xiangyang] Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
C3 Shanxi Medical University; Chinese Academy of Sciences; Institute of
   Psychology, CAS; Chinese Academy of Sciences; University of Chinese
   Academy of Sciences, CAS; Chinese Academy of Sciences; Institute of
   Psychology, CAS
RP Zhang, XY (corresponding author), Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
EM zhangxyxyx@sina.com
RI Zhang, Xiangyang/ABC-7380-2022; Sun, Yue/KHU-8159-2024; han,
   Yuyan/JPL-8939-2023; WANG, QIANWEN/KVY-5475-2024
OI Zhang, Xiangyang/0000-0003-3326-382X
FU Chinese National Programs for Brain Science and Brain-like Intelligence
   Technology [2021ZD0202102]
FX <B>Funding</B> This work was supported by the Chinese National Programs
   for Brain Science and Brain-like Intelligence Technology (2021ZD0202102
   to XYZ) .
CR Abbafati C, 2020, LANCET, V396, P1204
   Akbari H, 2017, J RES MED SCI, V22, DOI 10.4103/jrms.JRMS_288_16
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Balasubramaniam M, 2019, ANN CLIN PSYCHIATRY, V31, P277
   Butnoriene J, 2018, BMC PSYCHIATRY, V18, DOI 10.1186/s12888-017-1576-8
   Fava M, 2004, PSYCHOL MED, V34, P1299, DOI 10.1017/S0033291704002612
   Fava M, 2008, AM J PSYCHIAT, V165, P342, DOI 10.1176/appi.ajp.2007.06111868
   Fernandez-Aguilar J, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-66068-9
   Gomez AF, 2018, EXPERT OPIN PHARMACO, V19, P883, DOI 10.1080/14656566.2018.1472767
   Grimsrud A, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005552
   Grunebaum MF, 2005, J AFFECT DISORDERS, V87, P73, DOI 10.1016/j.jad.2005.03.002
   Hamer M, 2010, HYPERTENSION, V56, P547, DOI 10.1161/HYPERTENSIONAHA.110.153775
   Huang YC, 2022, WORLD J BIOL PSYCHIA, V23, P483, DOI 10.1080/15622975.2021.2013091
   Huang YQ, 2019, LANCET PSYCHIAT, V6, P211, DOI 10.1016/S2215-0366(18)30511-X
   Hung CI, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/1471-244X-14-185
   Kahl KG, 2015, BRAIN BEHAV, V5, DOI 10.1002/brb3.306
   Lenze EJ, 2001, DEPRESS ANXIETY, V14, P86, DOI 10.1002/da.1050
   Lenze EJ, 2000, AM J PSYCHIAT, V157, P722, DOI 10.1176/appi.ajp.157.5.722
   Lepor N E, 2001, Rev Cardiovasc Med, V2, P160
   Li ZZ, 2017, PSYCHONEUROENDOCRINO, V81, P113, DOI 10.1016/j.psyneuen.2017.03.015
   Lim LF, 2021, NEUROSCI BIOBEHAV R, V131, P96, DOI 10.1016/j.neubiorev.2021.08.031
   Lin CH, 2014, PSYCHIAT RES, V220, P855, DOI 10.1016/j.psychres.2014.08.048
   Mathialagan K, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.8598
   Mattei G, 2018, J NERV MENT DIS, V206, P316, DOI 10.1097/NMD.0000000000000807
   Pan Y, 2015, NEUROPSYCH DIS TREAT, V11, P1121, DOI 10.2147/NDT.S77710
   Perlis RH, 2018, AM J PSYCHIAT, V175, P500, DOI 10.1176/appi.ajp.2018.18040399
   Pfeiffer PN, 2009, DEPRESS ANXIETY, V26, P752, DOI 10.1002/da.20583
   PLATT S, 1992, ACTA PSYCHIAT SCAND, V85, P97, DOI 10.1111/j.1600-0447.1992.tb01451.x
   Saade YM, 2019, DEPRESS ANXIETY, V36, P1125, DOI 10.1002/da.22964
   Seo HJ, 2011, J NERV MENT DIS, V199, P42, DOI 10.1097/NMD.0b013e3182043b60
   Shao RY, 2020, BMC PSYCHOL, V8, DOI 10.1186/s40359-020-00402-8
   Shinkov A, 2018, POSTGRAD MED, V130, P251, DOI 10.1080/00325481.2018.1410054
   Silarova B, 2015, J PSYCHOSOM RES, V78, P391, DOI 10.1016/j.jpsychores.2015.02.010
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Skogberg N, 2022, J PSYCHOSOM RES, V159, DOI 10.1016/j.jpsychores.2022.110944
   Stanley IH, 2018, J CONSULT CLIN PSYCH, V86, P946, DOI 10.1037/ccp0000342
   Tang F, 2017, PSYCHONEUROENDOCRINO, V77, P112, DOI 10.1016/j.psyneuen.2016.11.025
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Yang GH, 2013, LANCET, V381, P1987, DOI 10.1016/S0140-6736(13)61097-1
   Yang WQ, 2019, J AFFECT DISORDERS, V257, P200, DOI 10.1016/j.jad.2019.06.052
   Zarrouq B, 2021, BMC PSYCHIATRY, V21, DOI 10.1186/s12888-021-03271-6
NR 41
TC 1
Z9 1
U1 1
U2 2
PU ELSEVIER ESPANA SLU
PI BARCELONA
PA AV JOSEP TARRADELLAS, 20-30, 1ERA PLANTA, BARCELONA, CP-08029, SPAIN
SN 0213-6163
J9 EUR J PSYCHIAT
JI Eur. J. Psychiat.
PD OCT-DEC
PY 2023
VL 37
IS 4
AR 100217
DI 10.1016/j.ejpsy.2023.07.001
EA OCT 2023
PG 7
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA IF8G1
UT WOS:001164999700001
OA hybrid
DA 2025-06-11
ER

PT J
AU Bergmann, N
   Gyntelberg, F
   Faber, J
AF Bergmann, N.
   Gyntelberg, F.
   Faber, J.
TI The appraisal of chronic stress and the development of the metabolic
   syndrome: a systematic review of prospective cohort studies
SO ENDOCRINE CONNECTIONS
LA English
DT Review
DE metabolic syndrome; adiposity; hypertension; dyslipidemia; type 2
   diabetes mellitus; psychological stress; job stress
ID AMBULATORY BLOOD-PRESSURE; EFFORT-REWARD IMBALANCE; BODY-MASS INDEX;
   PSYCHOSOCIAL WORK FACTORS; JOB STRAIN; RISK-FACTORS; WEIGHT-GAIN;
   PSYCHOLOGICAL DISTRESS; CARDIOVASCULAR RISK; MARITAL ADJUSTMENT
AB Chronic psychosocial stress has been proposed as a risk factor for the development of the metabolic syndrome (MES). This review gives a systematic overview of prospective cohort studies investigating chronic psychosocial stress as a risk factor for incident MES and the individual elements of MES. Thirty-nine studies were included. An association between chronic psychosocial stress and the development of MES was generally supported. Regarding the four elements of MES: i) weight gain: the prospective studies supported etiological roles for relationship stress, perceived stress, and distress, while the studies on work-related stress (WS) showed conflicting results; ii) dyslipidemi: too few studies on psychosocial stress as a risk factor for dyslipidemia were available to draw a conclusion; however, a trend toward a positive association was present; iii) type 2 diabetes mellitus (DM2): prospective studies supported perceived stress and distress as risk factors for the development of DM2 among men, but not among women, while WS was generally not supported as a risk factor among neither men nor women; iv) hypertension: marital stress and perceived stress might have an influence on blood pressure (BP), while no association was found regarding distress. Evaluating WS the results were equivocal and indicated that different types of WS affected the BP differently between men and women. In conclusion, a longitudinal association between chronic psychosocial stress and the development of MES seems present. However, the number of studies with sufficient quality is limited and the design of the studies is substantially heterogeneous.
C1 [Bergmann, N.; Faber, J.] Herlev Univ Hosp, Dept Med O, Endocrine Unit, DK-2730 Herlev, Denmark.
   [Gyntelberg, F.] Natl Res Ctr Working Environm, Copenhagen, Denmark.
   [Faber, J.] Univ Copenhagen, Fac Hlth Sci, Copenhagen, Denmark.
C3 University of Copenhagen; Herlev & Gentofte Hospital; National Research
   Centre for the Working Environment; University of Copenhagen
RP Bergmann, N (corresponding author), Herlev Univ Hosp, Dept Med O, Endocrine Unit, DK-2730 Herlev, Denmark.
EM n.c.bergmann@hotmail.com
OI Bergmann, Natasha Chidekel/0000-0002-6797-8041
CR Allard KO, 2011, J OCCUP ENVIRON MED, V53, P1364, DOI 10.1097/JOM.0b013e3182363bda
   [Anonymous], 2012, CLIN PSYCHOMETRICS, DOI DOI 10.1002/9781118511800.APP15
   [Anonymous], 1988, USERSS GUIDE GEN HLT
   Baker B, 2000, ARCH INTERN MED, V160, P3453, DOI 10.1001/archinte.160.22.3453
   Berset M, 2011, SCAND J WORK ENV HEA, V37, P45, DOI 10.5271/sjweh.3089
   Björntorp P, 1999, DIABETES-METAB RES, V15, P427
   Block JP, 2009, AM J EPIDEMIOL, V170, P181, DOI 10.1093/aje/kwp104
   Brunner EJ, 2007, AM J EPIDEMIOL, V165, P828, DOI 10.1093/aje/kwk058
   Brunner EJ, 2013, NAT REV ENDOCRINOL, V9, P449, DOI 10.1038/nrendo.2013.124
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Choi B, 2014, J INTERN MED, V275, P438, DOI 10.1111/joim.12173
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Cosgrove MP, 2012, OCCUP MED-OXFORD, V62, P167, DOI 10.1093/occmed/kqs002
   Dweck JS, 2014, APPETITE, V72, P106, DOI 10.1016/j.appet.2013.10.001
   Edwards EM, 2012, J OCCUP ENVIRON MED, V54, P1447, DOI 10.1097/JOM.0b013e3182783f27
   Eek F, 2009, SCAND J PUBLIC HEALT, V37, P532, DOI 10.1177/1403494809104359
   Eriksson AK, 2008, DIABETIC MED, V25, P834, DOI 10.1111/j.1464-5491.2008.02463.x
   Eriksson AK, 2013, DIABETES CARE, V36, P2683, DOI 10.2337/dc12-1738
   Fauvel JP, 2003, HYPERTENSION, V42, P1112, DOI 10.1161/01.HYP.0000102862.93418.EE
   Fowler-Brown AG, 2009, OBESITY, V17, P2106, DOI 10.1038/oby.2009.130
   Gerace TA, 1996, PREV MED, V25, P593, DOI 10.1006/pmed.1996.0094
   Gilbert-Ouimet M, 2012, J PSYCHOSOM RES, V72, P26, DOI 10.1016/j.jpsychores.2011.07.002
   Gilbert-Ouimet M, 2014, SCAND J WORK ENV HEA, V40, P109, DOI 10.5271/sjweh.3390
   Gimeno D, 2010, OCCUP ENVIRON MED, V67, P256, DOI 10.1136/oem.2009.047324
   Goldstein DS, 2002, STRESS, V5, P54, DOI 10.1080/10253890290012345
   Goodwin JE, 2012, PEDIATR NEPHROL, V27, P1059, DOI 10.1007/s00467-011-1928-4
   Guimont C, 2006, AM J PUBLIC HEALTH, V96, P1436, DOI 10.2105/AJPH.2004.057679
   Heraclides AM, 2012, OBESITY, V20, P428, DOI 10.1038/oby.2011.95
   Heslop P, 2002, SOC SCI MED, V54, P1589, DOI 10.1016/S0277-9536(01)00138-1
   Holmes ME, 2010, OBES REV, V11, P492, DOI 10.1111/j.1467-789X.2009.00680.x
   Ishizaki M, 2008, SCAND J WORK ENV HEA, V34, P288, DOI 10.5271/sjweh.1267
   Karasek R, 1998, J Occup Health Psychol, V3, P322, DOI 10.1037/1076-8998.3.4.322
   Kato M, 2009, ENDOCR J, V56, P459, DOI 10.1507/endocrj.K09E-003
   Kawakami N, 1999, J EPIDEMIOL COMMUN H, V53, P359, DOI 10.1136/jech.53.6.359
   Kivimäki M, 2006, INT J OBESITY, V30, P982, DOI 10.1038/sj.ijo.0803229
   Kivimäki M, 2002, BRIT MED J, V325, P857, DOI 10.1136/bmj.325.7369.857
   Kivimäki M, 2007, AM J HYPERTENS, V20, P1146, DOI 10.1016/j.amjhyper.2007.06.006
   Korkeila M, 1998, INT J OBESITY, V22, P949, DOI 10.1038/sj.ijo.0800694
   Kouvonen A, 2006, BMC PUBLIC HEALTH, V6, DOI 10.1186/1471-2458-6-24
   Kouvonen A, 2011, AM J PUBLIC HEALTH, V101, P1474, DOI 10.2105/AJPH.2010.300115
   Kroenke CH, 2007, AM J EPIDEMIOL, V165, P175, DOI 10.1093/aje/kwj355
   Kumari M, 2004, ARCH INTERN MED, V164, P1873, DOI 10.1001/archinte.164.17.1873
   Lallukka T, 2008, EUR J EPIDEMIOL, V23, P303, DOI 10.1007/s10654-008-9233-7
   Landsbergis P, 2000, OCCUP MED-STATE ART, V15, P163
   Landsbergis PA, 2013, AM J PUBLIC HEALTH, V103, pE61, DOI 10.2105/AJPH.2012.301153
   Levenstein S, 2001, ARCH INTERN MED, V161, P1341, DOI 10.1001/archinte.161.10.1341
   Macfarlane DP, 2008, J ENDOCRINOL, V197, P189, DOI 10.1677/JOE-08-0054
   Magee CA, 2010, J OCCUP ENVIRON MED, V52, P977, DOI 10.1097/JOM.0b013e3181f26e72
   Markovitz JH, 2004, ANN BEHAV MED, V28, P4, DOI 10.1207/s15324796abm2801_2
   Matud MP, 2004, PERS INDIV DIFFER, V37, P1401, DOI 10.1016/j.paid.2004.01.010
   Mente A, 2010, J AM COLL CARDIOL, V55, P2390, DOI 10.1016/j.jacc.2009.12.053
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Mommersteeg PMC, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-1109
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Myers MG, 1999, AM J HYPERTENS, V12, P1149, DOI 10.1016/S0895-7061(99)00199-5
   NIAURA R, 1992, BIOL PSYCHOL, V34, P1, DOI 10.1016/0301-0511(92)90022-M
   Novak M, 2013, DIABETIC MED, V30, pE8, DOI 10.1111/dme.12037
   Nyberg ST, 2012, J INTERN MED, V272, P65, DOI 10.1111/j.1365-2796.2011.02482.x
   Öhlin B, 2007, J HYPERTENS, V25, P525
   Oksanen T, 2012, J HYPERTENS, V30, P1129, DOI 10.1097/HJH.0b013e32835377ed
   Pouwer F, 2010, DISCOV MED, V9, P112
   Puustinen PJ, 2011, PSYCHOSOM MED, V73, P158, DOI 10.1097/PSY.0b013e3182037315
   Quist HG, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-43
   Räikkönen K, 2007, DIABETES CARE, V30, P872, DOI 10.2337/dc06-1857
   Rod NH, 2009, J INTERN MED, V266, P467, DOI 10.1111/j.1365-2796.2009.02124.x
   Roos E, 2013, ARCH ENVIRON OCCUP H, V68, P166, DOI 10.1080/19338244.2012.686931
   Rosmond R, 2005, PSYCHONEUROENDOCRINO, V30, P1, DOI 10.1016/j.psyneuen.2004.05.007
   Schnall PL, 1998, PSYCHOSOM MED, V60, P697, DOI 10.1097/00006842-199811000-00007
   Schubert C, 2009, BIOL PSYCHOL, V80, P325, DOI 10.1016/j.biopsycho.2008.11.005
   Siegrist J, 2004, SOC SCI MED, V58, P1483, DOI 10.1016/S0277-9536(03)00351-4
   Smith PM, 2012, OCCUP MED-OXFORD, V62, P413, DOI 10.1093/occmed/kqs128
   Sparrenberger F, 2009, J HUM HYPERTENS, V23, P12, DOI 10.1038/jhh.2008.74
   Tobe SW, 2007, AM J HYPERTENS, V20, P148, DOI 10.1016/j.amjhyper.2006.07.011
   Toker S, 2012, J OCCUP HEALTH PSYCH, V17, P259, DOI 10.1037/a0028401
   Toshihiro M, 2008, DIABETIC MED, V25, P1211, DOI 10.1111/j.1464-5491.2008.02566.x
   Troxel WM, 2005, ARCH INTERN MED, V165, P1022, DOI 10.1001/archinte.165.9.1022
   van Holland BJ, 2012, INT ARCH OCC ENV HEA, V85, P849, DOI 10.1007/s00420-011-0727-3
   Wardle J, 2011, OBESITY, V19, P771, DOI 10.1038/oby.2010.241
   Whisman MA, 2012, HEALTH PSYCHOL, V31, P80, DOI 10.1037/a0025671
   Williams ED, 2013, ANN BEHAV MED, V46, P62, DOI 10.1007/s12160-013-9473-y
   Zellner DA, 2006, PHYSIOL BEHAV, V87, P789, DOI 10.1016/j.physbeh.2006.01.014
NR 81
TC 154
Z9 170
U1 0
U2 24
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
EI 2049-3614
J9 ENDOCR CONNECT
JI Endocr. Connect.
PD JUN 1
PY 2014
VL 3
IS 2
BP R55
EP R80
DI 10.1530/EC-14-0031
PG 26
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA V44UM
UT WOS:000209773900003
PM 24743684
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Moon, WH
   Kwon, M
   Kim, SA
AF Moon, Weon-Hee
   Kwon, Myoungjin
   Kim, Sun Ae
TI Examining the health-related quality of life of middle-aged men with
   metabolic syndrome based on their stress level
SO JOURNAL OF MENS HEALTH
LA English
DT Article
DE quality of life; middle aged; men; metabolic syndrome; stress; mental
   health
ID PREVALENCE; COMMUNITY; SUPPORT; ADULTS
AB Background: This study was conducted to identify the factors that affect the health-related quality of life (HRQoL) of middle-aged men with metabolic syndrome (MetS) based on their stress level using data from the Korea National Health and Nutrition Examination Survey (KNHANES). Methods: The participants of this study were men aged between 40-64 with MetS who were included in the KNHANES. The main variables of this study were HRQoL, which was measured using the EuroQol-5 Dimension (EQ-5D); general characteristics, health-related characteristics, and dietary behaviors. Results: The subjective health of the group with less stress was significantly better. Compared to the unhealthy group, the groups perceived as healthy and normal had a higher HRQoL. The economic level, suicidal ideation, and dinner arrangement (presence of family) of the stressed group were significantly associated with their HRQoL. Compared to a low economic level, the high and middle economic levels were more associated with the subjects' BRQoL. Compared to the group without suicidal ideation, the group that experienced suicidal association had a lower HRQoL. Compared to the group that did not dine with their family, the group that dined with family had a higher HRQoL. Conclusions: The results of this study expand the scientific understanding of HRQol., based on stress among middle-aged men with metabolic syndrome. Since differences in the influence of the factors that affect HRQoL were identified based on the level of stress experienced, the stress level of middle-aged men should be considered when devising an intervention strategy to improve their HRQoL.
C1 [Moon, Weon-Hee] Pai Chai Univ, Dept Nursing Sci, Daejeon 35345, South Korea.
   [Kwon, Myoungjin] Daejeon Univ, Dept Nursing, Daejeon 34520, South Korea.
   [Kim, Sun Ae] Korea Natl Univ Transportat, Dept Nursing, Chungbuk 27909, South Korea.
C3 Pai Chai University; Daejeon University; Korea National University of
   Transportation
RP Kwon, M (corresponding author), Daejeon Univ, Dept Nursing, Daejeon 34520, South Korea.; Kim, SA (corresponding author), Korea Natl Univ Transportat, Dept Nursing, Chungbuk 27909, South Korea.
EM mjkwon@dju.kr; sakim@ut.ac.kr
RI Kim, Sun/G-3451-2013; Kwon, Myoungjin/AAG-1779-2020
FU Pai Chai University
FX This research was partially supported by the Pai Chai University
   research grant in 2020.
CR [Anonymous], 2019, Population projections
   [Anonymous], 2006, LATE DINNER AGAIN WO
   Tran BT, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-016-3936-6
   차은정, 2012, [Korean Journal of Adult Nursing, 성인간호학회지], V24, P428
   Charmaz K., 1995, MENS HLTH ILLNESS GE, P266
   Cherepanov D, 2010, QUAL LIFE RES, V19, P1115, DOI 10.1007/s11136-010-9673-x
   Chin EY, 2016, J KOREAN ACAD NURS, V46, P215, DOI 10.4040/jkan.2016.46.2.215
   Cho E, 2013, COMMIMITY WORK FAM, V16, P88, DOI 10.1080/13668803.2012.722010
   Cho Y, 2019, J KOREAN ACAD NURS, V49, P104, DOI 10.4040/jkan.2019.49.1.104
   Choi MJ, 2020, J NUTR EDUC BEHAV, V52, P758, DOI 10.1016/j.jneb.2019.11.013
   Choi YJ, 2011, DIABETES METAB J, V35, P587, DOI 10.4093/dmj.2011.35.6.587
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cohen BE, 2010, PSYCHIAT RES, V175, P133, DOI 10.1016/j.psychres.2009.02.004
   FACCHINI FS, 1992, LANCET, V339, P1128, DOI 10.1016/0140-6736(92)90730-Q
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Griendling KK, 2003, CIRCULATION, V108, P2034, DOI 10.1161/01.CIR.0000093661.90582.c4
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Jeong M, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17239058
   JEONG PARK MIN, 2015, [Korean Journal of Adult Nursing, 성인간호학회지], V27, P314, DOI 10.7475/kjan.2014.27.3.314
   Jung-Jeung Lee, 2014, [Journal of Agricultural Medicine&Community Health, 농촌의학.지역보건], V39, P37, DOI 10.5393/JAMCH.2014.39.1.037
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Khil JM, 2021, J NUTR HLTH, V54, P39
   Kim Chun Ja, 2010, [Korean Journal of Adult Nursing, 성인간호학회지], V22, P51
   Kim Min-hyun, 2020, Korean Journal of Family Practice, V10, P44, DOI 10.21215/kjfp.2020.10.1.44
   Kimura Y, 2012, J NUTR HEALTH AGING, V16, P728, DOI 10.1007/s12603-012-0067-3
   Korea Centers for Disease Control and Prevention, 2009, 4 KOR NAT HLTH NUTR
   Kwon Myoung Jin, 2020, [Journal of the Korea Convergence Society, 한국융합학회논문지], V11, P373, DOI 10.15207/JKCS.2020.11.5.373
   Lee H, 2014, J KOREAN ACAD NURS, V44, P608, DOI 10.4040/jkan.2014.44.6.608
   Lim S, 2011, DIABETES CARE, V34, P1323, DOI 10.2337/dc10-2109
   Lloyd C., 2005, Diabetes Spectrum, V18, P121, DOI 10.2337/diaspect.18.2.121
   Otero-Rodríguez A, 2010, QUAL LIFE RES, V19, P15, DOI 10.1007/s11136-009-9561-4
   Panel on Opportunistic Infections in Adults and Adolescents with HIV, 2019, GUID PREV TREATM OPP
   Park H, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15112327
   Park HE, 2019, HEALTH QUAL LIFE OUT, V17, DOI 10.1186/s12955-019-1078-0
   Raum E, 2012, DIABETES RES CLIN PR, V97, P377, DOI 10.1016/j.diabres.2012.05.026
   Santos M, 2021, J MENS HEALTH, V17, P62, DOI 10.31083/jomh.2021.079
   Slopen N, 2012, NICOTINE TOB RES, V14, P1161, DOI 10.1093/ntr/nts011
   Smith J, 2002, DIABETIC MED, V19, P98
   Soo Kim Hyang, 2018, [Journal of the Korea Convergence Society, 한국융합학회논문지], V9, P133, DOI 10.15207/JKCS.2018.9.6.133
   Thoits PA, 2011, J HEALTH SOC BEHAV, V52, P145, DOI 10.1177/0022146510395592
   Tsai TY, 2011, CLINICS, V66, P1531, DOI 10.1590/S1807-59322011000900004
   World Health Organization. Geneva: World Health Organization, 2012, WHOQOL WHO MEAS QUAL
NR 43
TC 0
Z9 0
U1 0
U2 2
PU MRE PRESS
PI SINGAPORE
PA 14 ROBINSON RD #08-01A FAR EAST FINANCE, SINGAPORE, SINGAPORE
SN 1875-6867
EI 1875-6859
J9 J MENS HEALTH
JI J. Mens Health
PD APR
PY 2022
VL 18
IS 4
AR 96
DI 10.31083/j.jomh1804096
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 1N1CP
UT WOS:000800400400014
OA gold
DA 2025-06-11
ER

PT J
AU van Dijk, G
   Buwalda, B
AF van Dijk, Gertjan
   Buwalda, Bauke
TI Neurobiology of the metabolic syndrome: An allostatic perspective
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article; Proceedings Paper
CT Spring Meeting of the European Journal of Pharmacology
CY SEP 14-16, 2007
CL NETHERLANDS
DE psychosocial stress; obesity; energy balance; human; (Rat)
ID MESSENGER-RNA EXPRESSION; STRESS-INDUCED ANOREXIA; PITUITARY-ADRENAL
   AXIS; DIET-INDUCED OBESITY; FOOD-INTAKE; ENERGY-BALANCE; SOCIAL STRESS;
   BODY-WEIGHT; DIABETES-MELLITUS; ANXIETY DISORDERS
AB The metabolic syndrome is a cluster of more or less related metabolic and cardiovascular derangements including visceral obesity, insulin resistance, blood and tissue dislipidemia, high blood pressure and it is often associated with neuroendocrine and immunological dysregulations. The aetiology of this syndrome is clinically highly relevant because it predisposes to life-threatening complications, such as Diabetes Mellitus, kidney failure, cardiovascular disease, and certain types of cancer. Contributing factors include a sedentary life-style combined with increased dietary fat intake and psychosocial stress. From a biological viewpoint, however, the metabolic syndrome can be considered as a maladaptive consequence of an initially successful adaptation to high environmental demands. As opposed to pre-historic times - when environmental demands were usually energy-costly (e.g., fight/flight/hunt) and nutritional resource often inadequate - energy-utilizing actions serve no longer an optimal solution to deal with environmental demands of current human society. This paper describes the interactions between psychosocial stress and nutrition and how these may affect emotional and metabolic components of the metabolic syndrome. A deeper understanding of these interactions is necessary to come to effective treatment and prevention of the metabolic syndrome in the future. (C) 2008 Elsevier B.V. All rights reserved.
C1 [van Dijk, Gertjan] Univ Groningen, Unit Neuroendocrinol, Ctr Behav & Neurosci, Ctr Biol, NL-9751 NN Haren, Netherlands.
C3 University of Groningen
RP van Dijk, G (corresponding author), Univ Groningen, Unit Neuroendocrinol, Ctr Behav & Neurosci, Ctr Biol, Kerklaan 30, NL-9751 NN Haren, Netherlands.
EM gertjan.van.dijk@rug.nl
RI Buwalda, Bauke/L-1427-2013
OI van Dijk, Gertjan/0000-0002-6565-4019
CR Adage T, 2001, J NEUROSCI, V21, P3639, DOI 10.1523/JNEUROSCI.21-10-03639.2001
   Adan Roger A. H., 2006, CNS & Neurological Disorders-Drug Targets, V5, P251, DOI 10.2174/187152706777452290
   AKANA SF, 1994, ENDOCRINOLOGY, V135, P1125, DOI 10.1210/en.135.3.1125
   [Anonymous], 1964, On the Origin of Species
   [Anonymous], 2002, WHO TECHNICAL SERIES, V912
   ANTHONY J, 1991, CLIN SPORT MED, V10, P171
   Barrett GM, 2002, HORM BEHAV, V42, P85, DOI 10.1006/hbeh.2002.1804
   Bernard C, 1966, Introduction a la medecine experimentale
   Berridge KC, 2004, PHYSIOL BEHAV, V81, P179, DOI 10.1016/j.physbeh.2004.02.004
   Berthoud HR, 2004, PHYSIOL BEHAV, V81, P781, DOI 10.1016/j.physbeh.2004.04.034
   BJORNTORP P, 1992, ANN MED, V24, P465, DOI 10.3109/07853899209166997
   Björntorp P, 2000, INT J OBESITY, V24, pS80, DOI 10.1038/sj.ijo.0801285
   BLANCHARD DC, 1990, NEUROSCI BIOBEHAV R, V14, P455, DOI 10.1016/S0149-7634(05)80068-5
   Boden G, 2002, EUR J CLIN INVEST, V32, P14, DOI 10.1046/j.1365-2362.32.s3.3.x
   BOHUS B, 1993, NEUROPSYCHOBIOLOGY, V28, P95, DOI 10.1159/000119008
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   Buwalda B, 2001, PHYSIOL BEHAV, V73, P371, DOI 10.1016/S0031-9384(01)00493-0
   Cannon W., 1932, The wisdom of the body
   Chaki S, 2007, CURR TOP MED CHEM, V7, P1145
   Chakravarthy MV, 2004, J APPL PHYSIOL, V96, P3, DOI 10.1152/japplphysiol.00757.2003
   Challis BG, 2004, P NATL ACAD SCI USA, V101, P4695, DOI 10.1073/pnas.0306931101
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   Clarke SD, 2001, J NUTR, V131, P1129, DOI 10.1093/jn/131.4.1129
   Cohen P, 2001, J CLIN INVEST, V108, P1113, DOI 10.1172/JCI13914
   Cummings DE, 2003, ANNU REV MED, V54, P453, DOI 10.1146/annurev.med.54.101601.152403
   Dabelea D, 2001, J PEDIATR ENDOCR MET, V14, P1085
   DALLMAN MF, 1993, FRONT NEUROENDOCRIN, V14, P303, DOI 10.1006/frne.1993.1010
   Densmore VS, 2006, ENDOCRINOLOGY, V147, P4486, DOI 10.1210/en.2006-0106
   Dockray G, 2004, CURR OPIN PHARMACOL, V4, P557, DOI 10.1016/j.coph.2004.05.005
   Drazen DL, 2003, DIABETES, V52, P2928, DOI 10.2337/diabetes.52.12.2928
   Elmquist JK, 2001, PHYSIOL BEHAV, V74, P703, DOI 10.1038/sj.ijo.0801918
   ELY DL, 1978, HORM BEHAV, V10, P156, DOI 10.1016/0018-506X(78)90005-3
   Fan T, 2000, ENDOCRINOLOGY, V141, P3072
   Farooqi IS, 2005, ANNU REV MED, V56, P443, DOI 10.1146/annurev.med.56.062904.144924
   Farooqi IS, 2004, RECENT PROG HORM RES, V59, P409, DOI 10.1210/rp.59.1.409
   Figlewicz DP, 2003, AM J PHYSIOL-REG I, V284, pR882, DOI 10.1152/ajpregu.00602.2002
   FOKKEMA DS, 1995, PHYSIOL BEHAV, V57, P857, DOI 10.1016/0031-9384(94)00333-Z
   HALES CN, 1992, DIABETOLOGIA, V35, P595, DOI 10.1093/ije/dyt133
   HETHERINGTON AW, 1983, NUTR REV, V41, P124
   Hotta K, 2000, ARTERIOSCL THROM VAS, V20, P1595, DOI 10.1161/01.ATV.20.6.1595
   Huang XF, 2004, DIABETES OBES METAB, V6, P35, DOI 10.1111/j.1463-1326.2004.00312.x
   Hutcheon JA, 2006, AM J OBSTET GYNECOL, V195, P488, DOI 10.1016/j.ajog.2006.01.107
   James PT, 2004, EUR J CARDIOV PREV R, V11, P3, DOI 10.1097/01.hjr.0000114707.27531.48
   Jeanrenaud B, 2000, INT J OBESITY, V24, pS74, DOI 10.1038/sj.ijo.0801283
   Karpac J, 2007, MOL CELL ENDOCRINOL, V265, P29, DOI 10.1016/j.mce.2006.12.035
   KENNEDY GC, 1953, PROC R SOC SER B-BIO, V140, P578, DOI 10.1098/rspb.1953.0009
   Kokare DM, 2005, BRAIN RES, V1043, P107, DOI 10.1016/j.brainres.2005.02.038
   Koolhaas JM, 1997, NEUROSCI BIOBEHAV R, V21, P775, DOI 10.1016/S0149-7634(96)00057-7
   Korte SM, 2005, NEUROSCI BIOBEHAV R, V29, P3, DOI 10.1016/j.neubiorev.2004.08.009
   Krude H, 2003, ANN NY ACAD SCI, V994, P233, DOI 10.1111/j.1749-6632.2003.tb03185.x
   la Fleur SE, 2005, ENDOCRINOLOGY, V146, P2193, DOI 10.1210/en.2004-1603
   LARSEN PJ, 1994, PEPTIDES, V15, P783, DOI 10.1016/0196-9781(94)90030-2
   LeDoux J, 2003, CELL MOL NEUROBIOL, V23, P727, DOI 10.1023/A:1025048802629
   LEIBEL RL, 1995, NEW ENGL J MED, V332, P621, DOI 10.1056/NEJM199503093321001
   LESCH KP, 1991, PROG NEURO-PSYCHOPH, V15, P723, DOI 10.1016/0278-5846(91)90001-H
   Levin BE, 2000, AM J PHYSIOL-REG I, V279, pR1357, DOI 10.1152/ajpregu.2000.279.4.R1357
   Liu J, 2007, ENDOCRINOLOGY, V148, P5531, DOI 10.1210/en.2007-0745
   Marchesini G, 2004, DIABETIC MED, V21, P383, DOI 10.1111/j.1464-5491.2004.01115.x
   Matson CA, 2000, AM J PHYSIOL-REG I, V278, pR882, DOI 10.1152/ajpregu.2000.278.4.R882
   McEwen B., 2002, END STRESS WE KNOW I
   McEwen BS, 2000, NEUROPSYCHOPHARMACOL, V22, P108, DOI 10.1016/S0893-133X(99)00129-3
   McEwen BS, 2003, MENT RETARD DEV D R, V9, P149, DOI 10.1002/mrdd.10074
   Meerlo P, 1996, PHYSIOL BEHAV, V60, P115, DOI 10.1016/0031-9384(95)02271-6
   Miller LA, 2005, J NEUROPSYCH CLIN N, V17, P1, DOI 10.1176/appi.neuropsych.17.1.1
   Moller DE, 2005, ANNU REV MED, V56, P45, DOI 10.1146/annurev.med.56.082103.104751
   Morens C, 2005, AM J PHYSIOL-REG I, V289, pR156, DOI 10.1152/ajpregu.00774.2004
   NEEL JV, 1962, AM J HUM GENET, V14, P353
   Oliver G, 2000, PSYCHOSOM MED, V62, P853, DOI 10.1097/00006842-200011000-00016
   Parton LE, 2007, NATURE, V449, P228, DOI 10.1038/nature06098
   Pecoraro N, 2005, NEUROBIOL LEARN MEM, V83, P188, DOI 10.1016/j.nlm.2004.11.005
   Pollard TM, 1997, COLLEGIUM ANTROPOL, V21, P17
   Rolls BJ, 2000, J NUTR, V130, p268S, DOI 10.1093/jn/130.2.268S
   Roozendaal B, 1997, NEUROBIOL LEARN MEM, V67, P176, DOI 10.1006/nlme.1996.3765
   Sapolsky, 1996, Stress, V1, P1, DOI 10.3109/10253899609001092
   SAWCHENKO PE, 1993, CIBA F SYMP, V172, P5
   Scharrer E, 1999, NUTRITION, V15, P704, DOI 10.1016/S0899-9007(99)00125-2
   SCHEURINK AJ, 1999, INT J OBES RELAT S3, V23, pS13
   Schultz W, 2002, NEURON, V36, P241, DOI 10.1016/S0896-6273(02)00967-4
   Schwartz MW, 2000, NATURE, V404, P661, DOI 10.1038/35007534
   Seeley RJ, 1997, NATURE, V390, P349, DOI 10.1038/37016
   Speakman John R, 2006, Diab Vasc Dis Res, V3, P7, DOI 10.3132/dvdr.2006.010
   Strubbe JH, 2002, NEUROSCI BIOBEHAV R, V26, P485, DOI 10.1016/S0149-7634(02)00016-7
   Sweitzer RA, 1996, J MAMMAL, V77, P1068, DOI 10.2307/1382787
   Tamashiro KLK, 2006, PHYSIOL BEHAV, V89, P536, DOI 10.1016/j.physbeh.2006.05.026
   Tamashiro KLK, 2005, FRONT NEUROENDOCRIN, V26, P27, DOI 10.1016/j.yfrne.2005.03.001
   Tamashiro KLK, 2004, PHYSIOL BEHAV, V80, P683, DOI 10.1016/j.physbeh.2003.12.002
   Tang-Christensen M, 1999, J CLIN ENDOCR METAB, V84, P711, DOI 10.1210/jc.84.2.711
   TEMPEL DL, 1992, PHYSIOL BEHAV, V52, P1161, DOI 10.1016/0031-9384(92)90476-I
   Van Dijk G, 1999, AM J PHYSIOL-REG I, V276, pR1425, DOI 10.1152/ajpregu.1999.276.5.R1425
   van Dijk G, 2005, ENDOCRINOLOGY, V146, P5247, DOI 10.1210/en.2005-0472
   van Dijk G, 2003, EUR J PHARMACOL, V480, P31, DOI 10.1016/j.ejphar.2003.08.090
   van Dijk G, 2001, J NEUROENDOCRINOL, V13, P913, DOI 10.1046/j.1365-2826.2001.00707.x
   vanDijk G, 1997, DIABETES, V46, P1911, DOI 10.2337/diabetes.46.11.1911
   VANOORTMERSSEN GA, 1971, BEHAVIOUR, V38, P1, DOI 10.1163/156853971X00014
   Vergoni AV, 1999, EUR J PHARMACOL, V369, P11, DOI 10.1016/S0014-2999(99)00045-X
   Vitaliano PP, 2002, PSYCHOSOM MED, V64, P418, DOI 10.1097/00006842-200205000-00006
   Wang HQ, 2002, AM J PHYSIOL-ENDOC M, V282, pE1352, DOI 10.1152/ajpendo.00230.2001
   Wardle J, 2000, J PSYCHOSOM RES, V48, P195, DOI 10.1016/S0022-3999(00)00076-3
   Woods SC, 2000, ANNU REV PSYCHOL, V51, P255, DOI 10.1146/annurev.psych.51.1.255
   Yaffe K, 2004, JAMA-J AM MED ASSOC, V292, P2237, DOI 10.1001/jama.292.18.2237
   Yaswen L, 1999, NAT MED, V5, P1066, DOI 10.1038/12506
   Young EA, 1996, MOL PSYCHIATR, V1, P149
   Zakrzewska KE, 1997, DIABETES, V46, P717, DOI 10.2337/diabetes.46.4.717
   ZHANG YY, 1994, NATURE, V372, P425, DOI 10.1038/372425a0
NR 104
TC 26
Z9 29
U1 0
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD MAY 6
PY 2008
VL 585
IS 1
BP 137
EP 146
DI 10.1016/j.ejphar.2007.11.079
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Pharmacology & Pharmacy
GA 305AD
UT WOS:000256149300016
PM 18395710
OA Green Published
DA 2025-06-11
ER

PT J
AU Arabi, A
   Nasrallah, D
   Mohsen, S
   Abugharbieh, L
   Al-Hashimi, D
   Almass, S
   Albasti, S
   Al-Ajmi, SA
   Khan, MN
   Zughaier, SM
AF Arabi, Ahmed
   Nasrallah, Dima
   Mohsen, Sara
   Abugharbieh, Lana
   Al-Hashimi, Dana
   Almass, Shaikha
   Albasti, Shahd
   Al-Ajmi, Saeed A.
   Khan, Muhammad Naseem
   Zughaier, Susu M.
TI Association between Serum Vitamin D Status and Circadian Syndrome: A
   Cross-Sectional Study
SO NUTRIENTS
LA English
DT Article
DE Vitamin D; Circadian Syndrome (CircS); Metabolic Syndrome (MetS); Type 2
   diabetes; NHANES
ID D DEFICIENCY; DEPRESSION; CELLS
AB Background: Circadian Syndrome (CircS) encompasses cardiometabolic risk factors and comorbidities, indicating an elevated susceptibility to cardiovascular disease and type 2 diabetes. Methods: This cross-sectional study aimed to investigate the association between vitamin D levels and each of the following: CircS, metabolic syndrome (MetS), and the individual components of CircS. Data from 14,907 adults who participated in the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2018 were utilized. CircS was defined based on MetS components, alongside depression, short sleep, and non-alcoholic fatty liver disease (NAFLD). Results: Our results indicated that low vitamin D levels exhibited meaningful associations with CircS, with vitamin D deficiency and inadequacy demonstrating 2.21-fold (95% CI 1.78-2.74, p < 0.001) and 1.33-fold (95% CI 1.14-1.54, p < 0.001) increases in CircS odds, respectively. The association between vitamin D deficiency and CircS was stronger than that with MetS. Additionally, a dose-response gradient in odds of CircS components, particularly with short sleep duration, was noted as serum vitamin D levels decreased. Conclusions: our findings highlight a significant association between low serum vitamin D levels and CircS and its components, particularly with short sleep. This suggests a potentially pivotal role of vitamin D in the pathogenesis of Circadian syndrome.
C1 [Arabi, Ahmed; Nasrallah, Dima; Mohsen, Sara; Abugharbieh, Lana; Al-Hashimi, Dana; Almass, Shaikha; Albasti, Shahd; Al-Ajmi, Saeed A.] Qatar Univ, Coll Med, QU Hlth, POB 2713, Doha, Qatar.
   [Khan, Muhammad Naseem] Qatar Univ, Coll Med, Dept Populat Med, QU Hlth, POB 2713, Doha, Qatar.
   [Zughaier, Susu M.] Qatar Univ, Coll Med, Dept Basic Med Sci, QU Hlth, POB 2713, Doha, Qatar.
C3 Qatar University; Qatar University; Qatar University
RP Khan, MN (corresponding author), Qatar Univ, Coll Med, Dept Populat Med, QU Hlth, POB 2713, Doha, Qatar.; Zughaier, SM (corresponding author), Qatar Univ, Coll Med, Dept Basic Med Sci, QU Hlth, POB 2713, Doha, Qatar.
EM naseem@qu.edu.qa; szughaier@qu.edu.qa
RI Zughaier, Susu/N-3185-2019; Khan, Muhammad/H-7722-2016
OI Zughaier, Susu/0000-0001-7487-8770; Arabi, Ahmed/0009-0009-1543-8287;
   Khan, Muhammad Naseem/0000-0002-0484-0985
FX The authors would like to thank the staff at the National Center for
   Health Statistics of the Centers for Disease Control for their efforts
   in designing, collecting, and organizing the NHANES data, as well as for
   creating the public database. The authors also thank Suhail Doi and
   Tawanda Chivese from the Department of Population Medicine, College of
   Medicine, QU Health, Qatar University for their valuable guidance and
   assistance in conceptualization and data analysis.
CR Akbar Z, 2023, NUTRIENTS, V15, DOI 10.3390/nu15153396
   Al-Qahtani FS, 2024, CUREUS J MED SCIENCE, V16, DOI 10.7759/cureus.58133
   Al-Shawwa B, 2020, J CLIN SLEEP MED, V16, P1119, DOI 10.5664/jcsm.8440
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Anglin RES, 2013, BRIT J PSYCHIAT, V202, P100, DOI 10.1192/bjp.bp.111.106666
   Bennouar S, 2021, J DIABETES METAB DIS, V20, P1309, DOI 10.1007/s40200-021-00857-5
   Bima A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13114127
   Chang AM, 2011, J PHYSIOL-LONDON, V589, P1095, DOI 10.1113/jphysiol.2010.201194
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Costanzo S, 2018, NUTR METAB CARDIOVAS, V28, P298, DOI 10.1016/j.numecd.2017.11.008
   Developing the Healthy Eating Index, 2023, The Healthy Eating Index
   Drinking Levels Defined, 2023, Overview of Alcohol Consumption
   Gao YX, 2023, METAB SYNDR RELAT D, V21, P581, DOI 10.1089/met.2023.0141
   Gholamzad A, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-47872-5
   Gilon P, 2014, CELL CALCIUM, V56, P340, DOI 10.1016/j.ceca.2014.09.001
   Gu WB, 2023, NUTRIENTS, V15, DOI 10.3390/nu15092101
   Gutierrez-Monreal MA, 2014, J BIOL RHYTHM, V29, P384, DOI 10.1177/0748730414549239
   Heo NJ, 2021, J CLIN MED, V10, DOI 10.3390/jcm10122611
   Huang X, 2023, BMC PUBLIC HEALTH, V23, DOI [10.1186/s12870-023-04200-3, 10.1186/s12889-023-16447-4]
   Jiang JJ, 2024, SLEEP BREATH, V28, P1679, DOI 10.1007/s11325-024-03031-2
   Johnson Clifford L, 2013, Vital Health Stat 2, P1
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Liang JH, 2023, JMIR PUBLIC HLTH SUR, V9, DOI 10.2196/45776
   Lin ZH, 2011, HEPATOLOGY, V53, P726, DOI 10.1002/hep.24105
   Loh HH, 2023, HORM-INT J ENDOCRINO, V22, P563, DOI 10.1007/s42000-023-00481-3
   Lyu J, 2024, J NUTR HEALTH AGING, V28, DOI 10.1016/j.jnha.2024.100220
   Maroufi NF, 2020, HORM MOL BIOL CLIN I, V41, DOI 10.1515/hmbci-2020-0033
   McDermott JE, 2024, J PROTEOME RES, V23, P1547, DOI 10.1021/acs.jproteome.3c00418
   Muscogiuri G, 2019, SLEEP MED, V54, P262, DOI 10.1016/j.sleep.2018.10.033
   Mutt SJ, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061229
   Orozco-Solis R, 2014, NEUROSCIENCE, V264, P76, DOI 10.1016/j.neuroscience.2014.01.043
   Panda S, 2019, NAT REV ENDOCRINOL, V15, P67, DOI 10.1038/s41574-018-0142-x
   Romano F, 2020, CURR PHARM DESIGN, V26, P2492, DOI 10.2174/1381612826666200310145935
   ROSS A, 2011, DIETARY REFERENCE IN
   Russell KL, 2023, SLEEP BREATH, V27, P2139, DOI 10.1007/s11325-023-02828-x
   Smolensky MH, 2015, CHRONOBIOL INT, V32, P1029, DOI 10.3109/07420528.2015.1072002
   Szymczak-Pajor I, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21186644
   Theik NWY, 2021, CUREUS J MED SCIENCE, V13, DOI 10.7759/cureus.17419
   Tian H, 2024, HELIYON, V10, DOI 10.1016/j.heliyon.2024.e28738
   Xia YT, 2023, FOODS, V12, DOI 10.3390/foods12213973
   Zhang T, 2025, INT J ENVIRON HEAL R, V35, P301, DOI 10.1080/09603123.2024.2352076
NR 41
TC 5
Z9 5
U1 3
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2024
VL 16
IS 13
AR 2111
DI 10.3390/nu16132111
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA YQ9Y7
UT WOS:001270078700001
PM 38999859
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Asbury, EA
   Slattery, C
   Grant, A
   Evans, L
   Barbir, M
   Collins, P
AF Asbury, Elizabeth A.
   Slattery, Colin
   Grant, Amanda
   Evans, Lynda
   Barbir, Mahmoud
   Collins, Peter
TI Cardiac rehabilitation for the treatment of women with chest pain and
   normal coronary arteries
SO MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
LA English
DT Article
DE cardiac rehabilitation; chest pain; quality of life; psychology;
   exercise tolerance
ID QUALITY-OF-LIFE; SYNDROME-X; HEART-DISEASE; ANXIETY QUESTIONNAIRE;
   POSTMENOPAUSAL WOMEN; EXERCISE TOLERANCE; ANGINA; DEPRESSION;
   ARTERIOGRAMS; ANGIOGRAMS
AB Objective: To explore cardiac rehabilitation (CR) as a treatment for psychological and physiological morbidity in women with chest pain and normal coronary arteries (cardiac syndrome X).
   Design: Sixty-four women aged 57.3 8.6 years (mean +/- SD) with cardiac syndrome X were randomly assigned to an 8-week phase III CR exercise program or symptom monitoring control. All women completed the Hospital Anxiety and Depression Scale, Health Anxiety Questionnaire, and Short Form-36 before and after intervention and at the 8-week follow-up. CR patients underwent physical assessment before and after CR.
   Results: After CR, patients demonstrated improved symptom severity (2.0 +/- 0.8 vs 1.26 +/- 1.1, P = 0.009), Hospital Anxiety and Depression Scale depression score (8.0 +/- 3.4 vs 6.4 +/- 3.1, P = 0.04), total Health Anxiety Questionnaire score (12.0 +/- 5.5 vs 9.5 +/- 6.0, P = 0.008), health worry (4.5 +/- 3.1 vs 3.52 +/- 2.4, P = 0.025) and interference (2.4 +/- 1.8 vs 1.6 +/- 1.8, P = 0.004), SF-36 physical functioning (53.1 +/- 20.4 vs 62.3 +/- 23.9, P = 0.006), energy (36.3 +/- 20.7 vs 49.8 +/- 19.1, P < 0.001), pain (49.9 +/- 20.7 vs 58.1 +/- 22.9, P = 0.028), and general health (48.8 +/- 17.9 vs 57.6 +/- 17.0, P = 0.01) not found among the control women. Improvements were maintained at follow-up. CR patients showed significant improvements in Shuttle Walk Test performance (326.8 +/- 111.0 vs 423.6 +/- 133.2 in, P < 0.001), diastolic blood pressure (84.7 +/- 9.4 vs 79.7 +/- 7.3 mm Hg, P = 0.007), and body mass index (29.1 +/- 6.0 vs 28.4 +/- 6.17 kg/m(2), p = 0.003).
   Conclusions: An 8-week phase III CR program improves exercise tolerance, quality of life, psychological morbidity, symptom severity, and cardiovascular risk factors in women with cardiac syndrome X.
C1 [Asbury, Elizabeth A.; Collins, Peter] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Dept Cardiac Med, London SW3 6LY, England.
   [Slattery, Colin; Grant, Amanda; Evans, Lynda; Barbir, Mahmoud] Royal Brompton & Harefield NHS Trust, Harefield Hosp, London, England.
C3 Imperial College London; Royal Brompton & Harefield NHS Foundation
   Trust; Harefield Hospital; Royal Brompton Hospital
RP Asbury, EA (corresponding author), Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Dept Cardiac Med, Dovehouse St, London SW3 6LY, England.
EM e.asbury@impedal.ac.uk
CR Adamson DL, 2001, MENOPAUSE, V8, P233, DOI 10.1097/00042192-200107000-00003
   Altman DG, 1990, PRACTICAL STAT MED R
   Asbury EA, 2004, EUR HEART J, V25, P1695, DOI 10.1016/j.ehj.2004.07.035
   Babyak M, 2000, PSYCHOSOM MED, V62, P633, DOI 10.1097/00006842-200009000-00006
   Biggs AM, 2004, GUT, V53, P180, DOI 10.1136/gut.2003.020974
   Brown G.W., 1978, SOCIAL ORIGINS DEPRE
   Brown Kimberley, 2003, Br J Nurs, V12, P904
   CANNON RO, 1990, J AM COLL CARDIOL, V16, P1359, DOI 10.1016/0735-1097(90)90377-2
   CANNON RO, 1988, AM J CARDIOL, V61, P1338, DOI 10.1016/0002-9149(88)91180-0
   CANNON RO, 1994, NEW ENGL J MED, V330, P1411, DOI 10.1056/NEJM199405193302003
   Eifert GH, 2000, BEHAV RES THER, V38, P1039, DOI 10.1016/S0005-7967(99)00132-1
   Eriksson BE, 2000, J AM COLL CARDIOL, V36, P1619, DOI 10.1016/S0735-1097(00)00931-1
   Jessurun G, 2003, EUR J PAIN, V7, P507, DOI 10.1016/S1090-3801(03)00022-3
   Kaski JC, 2006, HEART, V92, P5, DOI 10.1136/hrt.2005.070318
   Kaski JC, 1998, AM HEART J, V136, P412, DOI 10.1016/S0002-8703(98)70214-5
   KEMP HG, 1973, AM J CARDIOL, V32, P375, DOI 10.1016/S0002-9149(73)80150-X
   KLIMES I, 1990, PSYCHOL MED, V20, P605, DOI 10.1017/S0033291700017116
   Lanza GA, 2007, HEART, V93, P159, DOI 10.1136/hrt.2005.067330
   Lavie Carl J, 2004, Am J Geriatr Cardiol, V13, P125, DOI 10.1111/j.1076-7460.2004.03285.x
   Lavie CJ, 2004, AM J CARDIOL, V93, P336, DOI 10.1016/j.amjcard.2003.10.015
   LEAF DA, 1993, CLIN CARDIOL, V16, P65, DOI 10.1002/clc.4960160114
   Lear SA, 2001, CURR CONTR TRIALS C, V2, P221, DOI 10.1186/CVM-2-5-221
   LIKOFF W, 1967, NEW ENGL J MED, V276, P1063, DOI 10.1056/NEJM196705112761904
   Lucock MP, 1996, BRIT J HEALTH PSYCH, V1, P137, DOI 10.1111/j.2044-8287.1996.tb00498.x
   Marchionni N, 2003, CIRCULATION, V107, P2201, DOI 10.1161/01.CIR.0000066322.21016.4A
   Milani RV, 1996, AM HEART J, V132, P726, DOI 10.1016/S0002-8703(96)90304-X
   Milani RV, 1998, AM J CARDIOL, V81, P1233, DOI 10.1016/S0002-9149(98)00121-0
   Özçelik F, 1999, CLIN CARDIOL, V22, P361
   Panting JR, 2002, NEW ENGL J MED, V346, P1948, DOI 10.1056/NEJMoa012369
   RADICE M, 1994, AM HEART J, V127, P531, DOI 10.1016/0002-8703(94)90659-9
   Rosano GMC, 1996, J AM COLL CARDIOL, V28, P1500
   Rosen SD, 2002, HEART, V87, P513, DOI 10.1136/heart.87.6.513
   Seki E, 2003, CIRC J, V67, P73, DOI 10.1253/circj.67.73
   Sgueglia GA, 2007, HEART, V93, P591, DOI 10.1136/hrt.2006.102194
   SINGH SJ, 1992, THORAX, V47, P1019, DOI 10.1136/thx.47.12.1019
   STEWART AL, 1988, MED CARE, V26, P724, DOI 10.1097/00005650-198807000-00007
   Turner SC, 2003, INT J CARDIOL, V92, P201, DOI 10.1016/S0167-5273(03)00086-X
   Tyni-Lenne Raija, 2002, Physiother Res Int, V7, P35, DOI 10.1002/pri.239
   ZIRMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361
   Zubieta JK, 2002, J NEUROSCI, V22, P5100, DOI 10.1523/JNEUROSCI.22-12-05100.2002
NR 40
TC 38
Z9 44
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1072-3714
J9 MENOPAUSE
JI Menopause-J. N. Am. Menopause Soc.
PD MAY-JUN
PY 2008
VL 15
IS 3
BP 454
EP 460
DI 10.1097/gme.0b013e31815982eb
PG 7
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 298MU
UT WOS:000255692600011
PM 18188136
DA 2025-06-11
ER

PT J
AU Purkayastha, S
   Zhang, H
   Zhang, G
   Ahmed, Z
   Wang, Y
   Cai, DS
AF Purkayastha, Sudarshana
   Zhang, Hai
   Zhang, Guo
   Ahmed, Zaghloul
   Wang, Yi
   Cai, Dongsheng
TI Neural dysregulation of peripheral insulin action and blood pressure by
   brain endoplasmic reticulum stress
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
ID UNFOLDED PROTEIN RESPONSE; CENTRAL-NERVOUS-SYSTEM; BETA/NF-KAPPA-B; ER
   STRESS; GLUCOSE-HOMEOSTASIS; TRANSLATIONAL CONTROL; LEPTIN RESISTANCE;
   OXIDATIVE STRESS; INFLAMMATION; OBESITY
AB Chronic endoplasmic reticulum (ER) stress was recently revealed to affect hypothalamic neuroendocrine pathways that regulate feeding and body weight. However, it remains unexplored whether brain ER stress could use a neural route to rapidly cause the peripheral disorders that underlie the development of type 2 diabetes (T2D) and the metabolic syndrome. Using a pharmacologic model that delivered ER stress inducer thapsigargin into the brain, this study demonstrated that a short-term brain ER stress over 3 d was sufficient to induce glucose intolerance, systemic and hepatic insulin resistance, and blood pressure (BP) increase. The collection of these changes was accompanied by elevated sympathetic tone and prevented by sympathetic suppression. Molecular studies revealed that acute induction of metabolic disorders via brain ER stress was abrogated by NF-kappa B inhibition in the hypothalamus. Therapeutic experiments further revealed that acute inhibition of brain ER stress with tauroursodeoxycholic acid (TUDCA) partially reversed obesity-associated metabolic and blood pressure disorders. In conclusion, ER stress in the brain represents a mediator of the sympathetic disorders that underlie the development of insulin resistance syndrome and T2D.
C1 [Purkayastha, Sudarshana; Zhang, Hai; Zhang, Guo; Wang, Yi; Cai, Dongsheng] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA.
   [Purkayastha, Sudarshana; Zhang, Hai; Zhang, Guo; Wang, Yi; Cai, Dongsheng] Albert Einstein Coll Med, Diabet Res Ctr, Bronx, NY 10461 USA.
   [Ahmed, Zaghloul] CUNY Coll Staten Isl, Dept Phys Therapy & Neurosci Program, Staten Isl, NY 10314 USA.
C3 Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva
   University; Yeshiva University; Montefiore Medical Center; Albert
   Einstein College of Medicine; City University of New York (CUNY) System;
   College of Staten Island (CUNY)
RP Cai, DS (corresponding author), Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA.
EM dongsheng.cai@einstein.yu.edu
RI Ahmed, zaghloul/AAV-8812-2021; Cai, Dongsheng/CAH-8271-2022
OI Zhang, Guo/0000-0002-3880-6996
FU National Institutes of Health [R01 DK078750, R01 AG031774]; American
   Diabetes Association [1-07-JF-09]
FX This study was supported by National Institutes of Health Grants R01
   DK078750 and R01 AG031774 and American Diabetes Association Junior
   Faculty Award 1-07-JF-09 (all to D. C.).
CR Ahima RS, 2000, ANNU REV PHYSIOL, V62, P413, DOI 10.1146/annurev.physiol.62.1.413
   Back SH, 2009, CELL METAB, V10, P13, DOI 10.1016/j.cmet.2009.06.002
   Cai DS, 2009, CELL CYCLE, V8, P2542, DOI 10.4161/cc.8.16.9386
   Cai DS, 2004, CELL, V119, P285, DOI 10.1016/j.cell.2004.09.027
   Cai DS, 2005, NAT MED, V11, P183, DOI 10.1038/nm1166
   Chae HJ, 2004, MOL CELL, V15, P355, DOI 10.1016/j.molcel.2004.06.038
   Cifuentes ME, 2006, CURR OPIN NEPHROL HY, V15, P179, DOI 10.1097/01.mnh.0000214776.19233.68
   Farah VMA, 2004, PHYSIOL BEHAV, V83, P135, DOI 10.1016/j.physbeh.2004.08.004
   Frisard M, 2006, ENDOCRINE, V29, P27, DOI 10.1385/ENDO:29:1:27
   Gelling RW, 2006, CELL METAB, V3, P67, DOI 10.1016/j.cmet.2005.11.013
   Glimcher LH, 2009, ANN NY ACAD SCI, V1173, pE2, DOI 10.1111/j.1749-6632.2009.04956.x
   Harding HP, 2001, MOL CELL, V7, P1153, DOI 10.1016/S1097-2765(01)00264-7
   Hetz C, 2009, GENE DEV, V23, P2294, DOI 10.1101/gad.1830709
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   Huang CJ, 2007, DIABETES, V56, P2016, DOI 10.2337/db07-0197
   Janson J, 2004, DIABETES, V53, P474, DOI 10.2337/diabetes.53.2.474
   KHOURY AF, 1991, JAMA-J AM MED ASSOC, V266, P394, DOI 10.1001/jama.266.3.394
   Klieverik LP, 2009, P NATL ACAD SCI USA, V106, P5966, DOI 10.1073/pnas.0805355106
   Lam TKT, 2005, NAT MED, V11, P320, DOI 10.1038/nm1201
   Lehrke M, 2004, NAT MED, V10, P126, DOI 10.1038/nm0204-126
   Ma YJ, 2004, J CHEM NEUROANAT, V28, P51, DOI 10.1016/j.jchemneu.2003.08.007
   Martinon F, 2010, NAT IMMUNOL, V11, P411, DOI 10.1038/ni.1857
   Morton GJ, 2006, NATURE, V443, P289, DOI 10.1038/nature05026
   Morton GJ, 2007, J PHYSIOL-LONDON, V583, P437, DOI 10.1113/jphysiol.2007.135590
   Myers MG, 2008, ANNU REV PHYSIOL, V70, P537, DOI 10.1146/annurev.physiol.70.113006.100707
   Nakagawa T, 2000, NATURE, V403, P98, DOI 10.1038/47513
   Obici S, 2002, NAT MED, V8, P1376, DOI 10.1038/nm798
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Oyadomari S, 2004, CELL DEATH DIFFER, V11, P381, DOI 10.1038/sj.cdd.4401373
   Ozcan L, 2009, CELL METAB, V9, P35, DOI 10.1016/j.cmet.2008.12.004
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Petersen KF, 2006, AM J MED, V119, p10S, DOI 10.1016/j.amjmed.2006.01.009
   Pocai A, 2005, NATURE, V434, P1026, DOI 10.1038/nature03439
   ROSS H, 1993, ANN INTERN MED, V119, P859, DOI 10.7326/0003-4819-119-8-199310150-00017
   Ruan H, 2004, CURR OPIN LIPIDOL, V15, P297, DOI 10.1097/00041433-200406000-00009
   Sachdeva MM, 2009, P NATL ACAD SCI USA, V106, P19090, DOI 10.1073/pnas.0904849106
   Schenk S, 2008, J CLIN INVEST, V118, P2992, DOI 10.1172/JCI34260
   Scheuner D, 2001, MOL CELL, V7, P1165, DOI 10.1016/S1097-2765(01)00265-9
   Scheuner D, 2008, ENDOCR REV, V29, P317, DOI 10.1210/er.2007-0039
   Shoelson SE, 2009, NAT MED, V15, P373, DOI 10.1038/nm0409-373
   Timmins JM, 2009, J CLIN INVEST, V119, P2925, DOI 10.1172/JCI38857
   Wang YG, 2009, NATURE, V460, P534, DOI 10.1038/nature08111
   Yan W, 2002, P NATL ACAD SCI USA, V99, P15920, DOI 10.1073/pnas.252341799
   Zhang XQ, 2008, CELL, V135, P61, DOI 10.1016/j.cell.2008.07.043
NR 45
TC 138
Z9 153
U1 0
U2 18
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD FEB 15
PY 2011
VL 108
IS 7
BP 2939
EP 2944
DI 10.1073/pnas.1006875108
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 721TB
UT WOS:000287377000059
PM 21282643
OA Green Published
DA 2025-06-11
ER

PT J
AU Tyagi, A
   Cohen, M
   Reece, J
   Telles, S
AF Tyagi, Anupama
   Cohen, Marc
   Reece, John
   Telles, Shirley
TI An explorative study of metabolic responses to mental stress and yoga
   practices in yoga practitioners, non-yoga practitioners and individuals
   with metabolic syndrome
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE Yoga; Meditation; Breathing; Metabolic syndrome; Oxygen consumption;
   Energy Expenditure; Metabolic rate; Stress reactivity; Stress recovery
ID EXAGGERATED CARDIAC REACTIONS; ACUTE PSYCHOLOGICAL STRESS;
   BLOOD-PRESSURE; CARDIOVASCULAR RISK; OXYGEN-CONSUMPTION;
   ENERGY-EXPENDITURE; HATHA YOGA; INDIRECT CALORIMETRY; HEART-RATE;
   REACTIVITY
AB Background: Stress places a metabolic burden on homeostasis and is linked to heightened sympathetic activity, increased energy expenditure and pathology. The yogic state is a hypometabolic state that corresponds with mind-body coherence and reduced stress. This study aimed to investigate metabolic responses to stress and different yoga practices in regular yoga practitioners (YP), non-yoga practitioners (NY) and metabolic syndrome patients (MS).
   Methods: YP (n = 16), NY (n = 15) and MS (n = 15) subjects underwent an experimental protocol that comprised of different 5-minute interventions including mental arithmetic stress test (MAST), alternate nostril breathing (ANB), Kapabhati breathing (KB) and meditation (Med) interspersed with 5 minutes of quiet resting (neutral condition (NC)). During the intervention periods continuous body weight adjusted oxygen consumption (VO2ml/min/kg) was measured using open circuit indirect calorimetry with a canopy hood.
   Results: This is the first study to report oxygen consumption (OC) in yoga practitioners during and after MAST and the first to report both within and between different populations. The results were analysed with SPSS 16 using 3X9 mixed factorial ANOVAs. The single between-subject factor was group (YP, NY and MS), the single within-subject factor was made up of the nine intervention phases (NC1, MAST, NC2, ANB, NC3, KB, NC4, Med, NC5). The results demonstrated that the regular YP group had significantly less OC and greater variability in their OC across all phases compared to the MS group (p =.003) and NY group (p = .01). All groups significantly raised their OC during the mental arithmetic stress, however the MS group had a significantly blunted post-stress recovery whereas the YP group rapidly recovered back to baseline levels with post stress recovery being greater than either the NY group or MS group.
   Conclusions: Yoga practitioners have greater metabolic variability compared to non-yoga practitioners and metabolic syndrome patients with reduced oxygen requirements during resting conditions and more rapid post-stress recovery. OC in metabolic syndrome patients displays significantly blunted post-stress recovery demonstrating reduced metabolic resilience. Our results support the findings of previous randomised trials that suggest regular yoga practice may mitigate against the effects of metabolic syndrome.
C1 [Tyagi, Anupama; Cohen, Marc] RMIT, Bundoora, Vic 3083, Australia.
   [Telles, Shirley] Patanjali Res Fdn, Haridwar 249402, Uttrakhand, India.
C3 Royal Melbourne Institute of Technology (RMIT)
RP Cohen, M (corresponding author), RMIT, West Campus,Bldg 201,Level 4, Bundoora, Vic 3083, Australia.
EM marc.cohen@rmit.edu.au
RI Cohen, Marc/GWV-0933-2022; Telles, Shirley/U-7154-2019
OI Cohen, Marc/0000-0002-5876-6565; Telles, Shirley/0000-0003-3562-1926
CR Abel AN, 2013, J ALTERN COMPLEM MED, V19, P185, DOI 10.1089/acm.2011.0516
   [Anonymous], 2008, NEW
   [Anonymous], CARDIOLOGY HOSP PHYS
   [Anonymous], 2005, The IDF consensus worldwide definition of the metabolic syndrome
   Arora Sarika, 2008, Int J Yoga, V1, P45, DOI 10.4103/0973-6131.43541
   Balanos GM, 2010, BIOL PSYCHOL, V85, P104, DOI 10.1016/j.biopsycho.2010.06.001
   BENSON H, 1978, J HUM STRESS, V4, P38, DOI 10.1080/0097840X.1978.9934985
   BENSON H, 1975, INT J PSYCHIAT MED, V6, P87, DOI 10.2190/376W-E4MT-QM6Q-H0UM
   Bera T K, 1998, Indian J Physiol Pharmacol, V42, P473
   Bernardi L, 2002, CIRCULATION, V105, P143, DOI 10.1161/hc0202.103311
   Bernardi L, 2001, J HYPERTENS, V19, P2221, DOI 10.1097/00004872-200112000-00016
   Bernardi L, 2001, BRIT MED J, V323, P1446, DOI 10.1136/bmj.323.7327.1446
   Bharshankar Jyotsana R., 2003, Indian Journal of Physiology and Pharmacology, V47, P202
   Bhasin MK, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0062817
   Bhavanani Ananda Balayogi, 2012, Indian J Physiol Pharmacol, V56, P273
   Bhavanani Ananda Balayogi, 2012, Int J Yoga, V5, P108, DOI 10.4103/0973-6131.98221
   Bhavanani Ananda Balayogi, 2011, Int J Yoga Therap, P21
   Block JP, 2009, AM J EPIDEMIOL, V170, P181, DOI 10.1093/aje/kwp104
   Bonnet MH, 2003, J INTERN MED, V254, P23, DOI 10.1046/j.1365-2796.2003.01176.x
   Brisbon NM, 2011, J RELIG HEALTH, V50, P931, DOI 10.1007/s10943-009-9305-3
   Brosschot JF, 1998, ANN BEHAV MED, V20, P326, DOI 10.1007/BF02886382
   Carlson LE, 2004, PSYCHONEUROENDOCRINO, V29, P448, DOI 10.1016/S0306-4530(03)00054-4
   CARROLL D, 1986, PSYCHOPHYSIOLOGY, V23, P174, DOI 10.1111/j.1469-8986.1986.tb00613.x
   Carroll D, 2012, PSYCHOPHYSIOLOGY, V49, P1444, DOI 10.1111/j.1469-8986.2012.01463.x
   Carroll D, 2009, PSYCHOPHYSIOLOGY, V46, P270, DOI 10.1111/j.1469-8986.2008.00762.x
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Chaya M S, 2008, Int J Yoga, V1, P27, DOI 10.4103/0973-6131.36761
   Chaya M S, 2006, BMC Complement Altern Med, V6, P28, DOI 10.1186/1472-6882-6-28
   Chen E, 2011, J ALLERGY CLIN IMMUN, V128, P970, DOI 10.1016/j.jaci.2011.06.040
   Chida Y, 2010, HYPERTENSION, V55, P1026, DOI 10.1161/HYPERTENSIONAHA.109.146621
   Cohen Beth E., 2008, Metabolic Syndrome and Related Disorders, V6, P223, DOI 10.1089/met.2008.0016
   Compher C, 2006, J AM DIET ASSOC, V106, P881, DOI 10.1016/j.jada.2006.02.009
   Danucalov MAD, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/513149
   Das SK, 2004, J NUTR, V134, P1412, DOI 10.1093/jn/134.6.1412
   DELISTRATY DA, 1992, PSYCHOPHYSIOLOGY, V29, P264, DOI 10.1111/j.1469-8986.1992.tb01696.x
   DILLBECK MC, 1987, AM PSYCHOL, V42, P879, DOI 10.1037/0003-066X.42.9.879
   ELSON BD, 1977, PSYCHOPHYSIOLOGY, V14, P52, DOI 10.1111/j.1469-8986.1977.tb01155.x
   Epel ES, 2013, CLIN PSYCHOL SCI, V1, P75, DOI 10.1177/2167702612460234
   Epel ES, 2009, HORM-INT J ENDOCRINO, V8, P7, DOI 10.14310/horm.2002.1217
   Epel ES, 2006, PSYCHONEUROENDOCRINO, V31, P277, DOI 10.1016/j.psyneuen.2005.08.011
   Epel ES, 2004, P NATL ACAD SCI USA, V101, P17312, DOI 10.1073/pnas.0407162101
   FISHER P, 1952, J CLIN INVEST, V31, P126, DOI 10.1172/JCI102571
   Flaa A, 2006, HYPERTENSION, V47, P396, DOI 10.1161/01.HYP.0000203952.27988.79
   Flaa A, 2008, METABOLISM, V57, P1422, DOI 10.1016/j.metabol.2008.05.012
   Flaa A, 2008, HYPERTENSION, V52, P336, DOI 10.1161/HYPERTENSIONAHA.108.111625
   Gerin W, 2000, J PSYCHOSOM RES, V48, P369, DOI 10.1016/S0022-3999(99)00095-1
   GOLEMAN DJ, 1976, J CONSULT CLIN PSYCH, V44, P456, DOI 10.1037/0022-006X.44.3.456
   Gopal Aravind, 2011, Int J Yoga, V4, P26, DOI 10.4103/0973-6131.78178
   Gothe N, 2013, J PHYS ACT HEALTH, V10, P488, DOI 10.1123/jpah.10.4.488
   Granath Jens, 2006, Cognitive Behaviour Therapy, V35, P3, DOI 10.1080/16506070500401292
   Hagins Marshall, 2007, BMC Complement Altern Med, V7, P40, DOI 10.1186/1472-6882-7-40
   Hagins M, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/649836
   Hartfiel N, 2012, OCCUP MED-OXFORD, V62, P606, DOI 10.1093/occmed/kqs168
   Haugen HA, 2007, NUTR CLIN PRACT, V22, P377, DOI 10.1177/0115426507022004377
   Heponiemi T, 2007, HEALTH PSYCHOL, V26, P13, DOI 10.1037/0278-6133.26.1.13
   HORSTMANN P, 1951, ACTA MED SCAND, V139, P326
   Huang FJ, 2013, J NURS RES, V21, P59, DOI 10.1097/jnr.0b013e3182829d6d
   Hunter SD, 2013, J BODYW MOV THER, V17, P322, DOI 10.1016/j.jbmt.2012.10.009
   Jae SY, 2014, ANN HUM BIOL, V41, P477, DOI 10.3109/03014460.2013.849756
   Jumpertz R, 2011, J CLIN ENDOCR METAB, V96, pE972, DOI 10.1210/jc.2010-2944
   Khalsa SBS, 2009, APPL PSYCHOPHYS BIOF, V34, P279, DOI 10.1007/s10484-009-9103-4
   Khatri Deepali, 2007, Diabetes Res Clin Pract, V78, pe9, DOI 10.1016/j.diabres.2007.05.002
   Kosmiski L, 2011, AM J CLIN NUTR, V94, p1677S, DOI 10.3945/ajcn.111.012625
   Kress JP, 1999, AM J RESP CRIT CARE, V160, P883, DOI 10.1164/ajrccm.160.3.9902058
   Kristal AR, 2005, ALTERN THER HEALTH M, V11, P28
   Kunz I, 2000, HYPERTENSION, V36, P26, DOI 10.1161/01.HYP.36.1.26
   Lee JA, 2012, MENOPAUSE, V19, P296, DOI 10.1097/gme.0b013e31822d59a2
   LEHRER PM, 1980, BEHAV RES THER, V18, P293, DOI 10.1016/0005-7967(80)90088-1
   Linden W, 1997, J PSYCHOSOM RES, V42, P117, DOI 10.1016/S0022-3999(96)00240-1
   Malathi A., 1999, Indian Journal of Physiology and Pharmacology, V43, P218
   Mason H, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/743504
   McArdle W. D., 2010, EXERCISE PHYSL NUTR
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   Muralikrishnan Krishnan, 2012, J Ayurveda Integr Med, V3, P91, DOI 10.4103/0975-9476.96528
   OBrien E., 1993, J HYPERTENS, V11, pS43
   Organization WH, 2011, Waist Circumference and Waist-Hip Ratio: Report of a WHO Expert Consultation
   Pal A, 2011, COMPLEMENT THER MED, V19, P122, DOI 10.1016/j.ctim.2011.05.001
   Pal GK, 2004, INDIAN J MED RES, V120, P115
   Phillips AC, 2011, BIOL PSYCHOL, V86, P106, DOI 10.1016/j.biopsycho.2010.03.016
   POEHLMAN ET, 1994, ANN INTERN MED, V121, P860, DOI 10.7326/0003-4819-121-11-199412010-00006
   Prakash Shivesh, 2007, Indian J Physiol Pharmacol, V51, P76
   Pramanik T, 2010, Nepal Med Coll J, V12, P154
   Rausch S., 2006, INTERNATIONALJOURNAL, V13, P273, DOI [https://doi.org/10.1037/1072-5245.13.3.273, DOI 10.1037/1072-5245.13.3.273, 10.1037/1072-5245.13.3.273]
   Roffey DM, 2006, JPEN-PARENTER ENTER, V30, P426, DOI 10.1177/0148607106030005426
   Ruggiero C, 2008, J GERONTOL A-BIOL, V63, P698, DOI 10.1093/gerona/63.7.698
   Saraswati N, 2005, PRANA PRANAYAMA PRAN
   SATO N, 1995, PSYCHOSOM MED, V57, P331, DOI 10.1097/00006842-199507000-00004
   Schmidt WD, 1996, J APPL PHYSIOL, V80, P638, DOI 10.1152/jappl.1996.80.2.638
   Schwartz AR, 2003, PSYCHOSOM MED, V65, P22, DOI 10.1097/01.PSY.0000046075.79922.61
   Selye H., 1975, STRESS LIFE
   Sharma G, 2007, J BODYW MOV THER, V11, P173, DOI 10.1016/j.jbmt.2007.01.002
   Smith C, 2007, COMPLEMENT THER MED, V15, P77, DOI 10.1016/j.ctim.2006.05.001
   Snodgrass JJ, 2008, AM J PHYS ANTHROPOL, V137, P145, DOI 10.1002/ajpa.20851
   Tarantino G, 2008, CLIN INVEST MED, V31, pE24
   Telles Shirley, 2012, Depress Res Treat, V2012, P401513, DOI 10.1155/2012/401513
   Telles S, 2010, MED SCI MONITOR, V16, pLE4
   Telles Shirley, 1994, Indian Journal of Physiology and Pharmacology, V38, P133
   Tooley GA, 2000, BIOL PSYCHOL, V53, P69, DOI 10.1016/S0301-0511(00)00035-1
   Tyagi A, 2013, J EVID-BASED INTEGR, V18, P290, DOI 10.1177/2156587213492770
   Tyagi A, 2014, ALTERN THER HEALTH M, V20, P32
   Valkeinen H, 2013, INT J GERONTOL, V7, P231, DOI 10.1016/j.ijge.2013.05.002
   van de Weijer T, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0051648
   Vyas Rashmi, 2002, Indian J Physiol Pharmacol, V46, P487
   Vyas Rashmi, 2008, Indian J Physiol Pharmacol, V52, P420
   WALLACE RK, 1971, AM J PHYSIOL, V221, P795, DOI 10.1152/ajplegacy.1971.221.3.795
   Wichitsranoi J, 2008, THAI J PHYSL SCI, V20, P62
   Wouters EFM, 2000, CHEST, V117, p274S, DOI 10.1378/chest.117.5_suppl_1.274S
   Yadav RK, 2012, J ALTERN COMPLEM MED, V18, P662, DOI 10.1089/acm.2011.0265
   Yoshihara K, 2011, BIOPSYCHOSOC MED, V5, DOI 10.1186/1751-0759-5-6
NR 109
TC 14
Z9 16
U1 1
U2 38
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD NOV 15
PY 2014
VL 14
AR 445
DI 10.1186/1472-6882-14-445
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA AX0YH
UT WOS:000346675400002
PM 25398263
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Repousi, N
   Masana, MF
   Sanchez-Niubo, A
   Haro, JM
   Tyrovolas, S
AF Repousi, Nikolena
   Masana, Maria F.
   Sanchez-Niubo, Albert
   Haro, Josep Maria
   Tyrovolas, Stefanos
TI Depression and metabolic syndrome in the older population: A review of
   evidence
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Review
DE Metabolic syndrome; Depression; Older adults
ID PROVISIONAL REPORT; YOUNG-ADULTS; RISK-FACTORS; SYMPTOMS; ASSOCIATION;
   ANXIETY; HEALTH; COMMUNITY; PEOPLE; DIAGNOSIS
AB Background: Metabolic syndrome (MetS) has been shown to be associated with depression in older adults but the results are mixed. We summarized and evaluated the association between depression and MetS in people aged 60 years or over.
   Methods: Relevant published studies from January 1997 to July 2017 were identified by searching two electronic databases: PubMed/Medline and EMBASE. Observational studies were considered.
   Results: Twelve studies were included in the systematic review. Depression seemed to be related with MetS in the majority of the studies (10/12=83.3%). As far as the longitudinal studies are concerned, the onset of depression was related to MetS in 2 out of 3 studies (66.6%), while a relation between chronicity of depression and MetS was reported (1 study). Regarding cross-sectional studies, 7 out of 9 (77.7%) concluded that there was a positive association between depression and MetS. Mixed evidence was found among studies concerning the association between depression and the individual components of MetS. Four out of ten studies (40%) reported that depression was significantly associated with the waist circumference, a component of MetS.
   Limitations: There was a high degree of heterogeneity between studies regarding their design. Only studies written in English, from peer-reviewed journals were included.
   Conclusions: Depression seemed to be significantly associated with MetS in people aged 60 years or over. Among the components of MetS, abdominal obesity seemed to be associated more strongly and consistently with depression. The direction of the causality and mechanisms underlying the relationship are still largely unknown.
C1 [Repousi, Nikolena] Natl & Kapodistrian Univ Athens, Med Sch, Mikras Asias St 75, Athens, Greece.
   [Masana, Maria F.; Sanchez-Niubo, Albert; Haro, Josep Maria; Tyrovolas, Stefanos] Univ Barcelona, Fundacio Sant Joan Deu, Dr Antoni Pujadas 42,Parc Sanitari Sant Joan Deu, Barcelona, Spain.
   [Masana, Maria F.; Sanchez-Niubo, Albert; Haro, Josep Maria; Tyrovolas, Stefanos] CIBERSAM, Ctr Invest Biomed Red Salud Mental, Inst Salud Carlos 3, Monforte Lemos 3-5, Madrid 28029, Spain.
   [Masana, Maria F.] Univ Barcelona, Fac Med, Casanova 143, E-08036 Barcelona, Spain.
   [Tyrovolas, Stefanos] Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,mSuite 600, Seattle, WA 98121 USA.
C3 National & Kapodistrian University of Athens; University of Barcelona;
   Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica
   en Red; CIBERSAM; University of Barcelona; University of Washington;
   University of Washington Seattle; Institute for Health Metrics &
   Evaluation
RP Tyrovolas, S (corresponding author), CIBERSAM, Fundacio Sant Joan de Deu, Dr Antoni Pujadas,42 St Boi Llobregat, Barcelona, Spain.
EM s.tyrovolas@pssjd.org
RI Haro, Josep Maria/D-1423-2011; Tyrovolas, Stefanos/M-2758-2014;
   Sanchez-Niubo, Albert/B-7517-2014
OI Sanchez-Niubo, Albert/0000-0003-0309-181X
FU Foundation for Education and European Culture (IPEP); Sara Borrell
   postdoctoral program from the Instituto de Salud Carlos III (ISCIII -
   Spain) [CD15/00019]; Fondos Europeo de Desarrollo Regional (FEDER);
   M-AES from the Instituto de Salud Carlos III [MV16/00035]
FX Stefanos Tyrovolas was supported by the Foundation for Education and
   European Culture (IPEP), the Sara Borrell postdoctoral program
   (reference no. CD15/00019 from the Instituto de Salud Carlos III (ISCIII
   - Spain) and the Fondos Europeo de Desarrollo Regional (FEDER). Stefanos
   was awarded with a 6 months visiting fellowship funding at IHME from
   M-AES (reference no. MV16/00035 from the Instituto de Salud Carlos III).
CR Akbaraly TN, 2011, DIABETES CARE, V34, P904, DOI 10.2337/dc10-1644
   Akbaraly TN, 2009, DIABETES CARE, V32, P499, DOI 10.2337/dc08-1358
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Almeida OP, 1999, INT J GERIATR PSYCH, V14, P858, DOI 10.1002/(SICI)1099-1166(199910)14:10<858::AID-GPS35>3.0.CO;2-8
   American Psychiatric Association, 2013, Diagnostic and Statistical Manual of Mental Disorders: DSM-IV, DOI [DOI 10.1176/APPI.BOOKS.9780890425596, 10.1176/appi.books.9780890425596]
   Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   [Anonymous], 2002, DIAGN STAT MAN MENT, V4th
   Badescu S V, 2016, J Med Life, V9, P120
   Balkau B, 1999, DIABETIC MED, V16, P442
   Borch-Johnsen K., 2013, Epidemiology of the metabolic syndrome, P7
   Butnoriene J, 2014, PSYCHONEUROENDOCRINO, V40, P269, DOI 10.1016/j.psyneuen.2013.11.002
   Costa E, 2006, INT PSYCHOGERIATR, V18, P493, DOI 10.1017/S1041610205002954
   Denys K, 2009, ACTA CLIN BELG, V64, P23, DOI 10.1179/acb.2009.006
   Després JP, 2008, ARTERIOSCL THROM VAS, V28, P1039, DOI 10.1161/ATVBAHA.107.159228
   Després JP, 2006, ANN MED, V38, P52, DOI 10.1080/07853890500383895
   Dinnes J., 2003, Health Technol Assess, V7, piii, DOI DOI 10.3310/HTA7270
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   Fiske A, 2009, ANNU REV CLIN PSYCHO, V5, P363, DOI 10.1146/annurev.clinpsy.032408.153621
   Foley DL, 2010, TWIN RES HUM GENET, V13, P347, DOI 10.1375/twin.13.4.347
   Gale CR, 2010, BIOL PSYCHIAT, V67, P189, DOI 10.1016/j.biopsych.2009.09.019
   Gheshlagh R. G., 2016, IRAN RED CRESCENT ME, V18
   Gil Katarzyna, 2006, Kardiol Pol, V64, P464
   Goldbacher EM, 2007, ANN BEHAV MED, V34, P240, DOI 10.1007/BF02874549
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Hildrum B, 2009, ACTA PSYCHIAT SCAND, V120, P14, DOI 10.1111/j.1600-0447.2008.01315.x
   Igna CV, 2008, PSYCHOSOM MED, V70, P960, DOI 10.1097/PSY.0b013e318189a942
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178, DOI 10.4088/JCP.v69n0202
   Levis B, 2017, AM J EPIDEMIOL, V185, P954, DOI 10.1093/aje/kww191
   Liaw FY, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/586251
   Liberati A, 2009, PLOS MED, V6, DOI [10.1371/journal.pmed.1000100, 10.7326/0003-4819-151-4-200908180-00136]
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Marazziti D, 2014, CNS SPECTRUMS, V19, P293, DOI 10.1017/S1092852913000667
   Mast BT, 2008, BIOL PSYCHIAT, V64, P320, DOI 10.1016/j.biopsych.2008.01.025
   McCaffery JM, 2003, PSYCHOSOM MED, V65, P490, DOI 10.1097/01.PSY.0000041545.52924.82
   Morikawa M, 2013, INT J GERIATR PSYCH, V28, P1251, DOI 10.1002/gps.3950
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Papakostas GI, 2004, EUR NEUROPSYCHOPHARM, V14, P135, DOI 10.1016/S0924-977X(03)00099-3
   Park S, 2014, PSYCHOSOMATICS, V55, P640, DOI 10.1016/j.psym.2013.12.010
   Prince MJ, 2015, LANCET, V385, P549, DOI 10.1016/S0140-6736(14)61347-7
   Pulkki-Råback L, 2009, HEALTH PSYCHOL, V28, P108, DOI 10.1037/a0012646
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Roriz-Cruz M, 2007, J AM GERIATR SOC, V55, P374, DOI 10.1111/j.1532-5415.2007.01068.x
   Roy T, 2012, J AFFECT DISORDERS, V142, pS8, DOI 10.1016/S0165-0327(12)70004-6
   Ruas LG, 2016, REV BRAS PSIQUIATR, V38, P183, DOI 10.1590/1516-4446-2015-1856
   Sheikh N, 2004, ACTA MED IRANICA, V42, P185
   Shen BJ, 2003, AM J EPIDEMIOL, V157, P701, DOI 10.1093/aje/kwg045
   Shin JY, 2008, ANN BEHAV MED, V36, P33, DOI 10.1007/s12160-008-9045-8
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Sözeri-Varma G, 2012, AGING DIS, V3, P465
   Takeuchi T, 2009, DIABETES METAB, V35, P32, DOI 10.1016/j.diabet.2008.06.006
   Thomas B H, 2004, Worldviews Evid Based Nurs, V1, P176, DOI 10.1111/j.1524-475X.2004.04006.x
   United Nations Department of Economic and Social Affairs Population Division, 2015, STESASERA390
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vanhala M, 2009, ACTA PSYCHIAT SCAND, V119, P137, DOI 10.1111/j.1600-0447.2008.01283.x
   Viscogliosi G, 2013, INT J GERIATR PSYCH, V28, P242, DOI 10.1002/gps.3817
   Vogelzangs N, 2007, J GERONTOL A-BIOL, V62, P563, DOI 10.1093/gerona/62.5.563
   Vogelzangs N, 2007, PSYCHONEUROENDOCRINO, V32, P151, DOI 10.1016/j.psyneuen.2006.11.009
   Vogelzangs N, 2011, J CLIN PSYCHIAT, V72, P598, DOI 10.4088/JCP.10m06559
   Vogelzangs N, 2009, AM J GERIAT PSYCHIAT, V17, P716, DOI 10.1097/JGP.0b013e3181aad5d7
   World Health Organization, 2012, DEPR GLOB PUBL HLTH
   World Health Organization [WHO], 2016, MENT HLTH OLD AD FAC
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 66
TC 48
Z9 58
U1 1
U2 25
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD SEP
PY 2018
VL 237
BP 56
EP 64
DI 10.1016/j.jad.2018.04.102
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA GH9DJ
UT WOS:000433968900008
PM 29772477
DA 2025-06-11
ER

PT J
AU Miola, A
   Pinna, M
   Manchia, M
   Tondo, L
   Baldessarini, RJ
AF Miola, Alessandro
   Pinna, Marco
   Manchia, Mirko
   Tondo, Leonardo
   Baldessarini, Ross J.
TI Overweight in mood disorders: Effects on morbidity and treatment
   response
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Affective; BMI; Body-weight; Depression; Mood; Obesity; Treatment
   response
ID BODY-MASS INDEX; MAJOR DEPRESSIVE DISORDER; BIPOLAR-DISORDER; SEDENTARY
   BEHAVIOR; METABOLIC SYNDROME; TREATMENT OUTCOMES; PHYSICAL-ACTIVITY;
   MENTAL-HEALTH; OBESITY; WEIGHT
AB Objective: As it is not clear how body-mass index (BMI) may relate to diagnosis, symptom-severity, illness-course, and treatment-response among psychiatric patients, we related BMI to psychiatric diagnosis and to selected clinical and demographic factors in major affective disorder subjects.
   Methods: We analyzed mean BMI levels vs. diagnosis, and evaluated selected risk factors for association with overweight and obesity among subjects with DSM-5 major affective disorders.
   Results: In 1884 subjects, BMI ranged from 23.4 kg/m(2) with anxiety disorders to 27.6 with psychotic disorders, and averaged 24.1 among 1469 affective disorder subjects. Mood-disorder subjects with BMI >= 25 (overweight/ obese) were more likely: men, older, married, with more children and siblings, less education, lower socioeconomic status, engaged less in physical exercise, smoked more, and lived in less densely populated areas. They also were more likely to have: BD than MDD, familial mood disorders, no co-occurring ADHD, higher serum triglyceride levels, more time depressed and less improvement in depression ratings with treatment.
   Conclusions: Risk of being overweight or obese was greatest with psychoses, least with anxiety, personality, and minor depressive disorders, and intermediate with major mood disorders. Several plausible risk factors for high BMI were identified in mood disorder subjects, including male sex and with BD > MDD. Striking were selectively greater prospective morbidity and decreased treatment-response for depression vs. mania with BMI >= 25.
C1 [Miola, Alessandro] Univ Padua, Dept Neurosci DNS, Padua, Italy.
   [Miola, Alessandro; Pinna, Marco; Manchia, Mirko; Tondo, Leonardo; Baldessarini, Ross J.] McLean Hosp, Mailman Res Ctr, Int Consortium Mood & Psychot Disorders Res, 115 Mill St, Belmont, MA 02178 USA.
   [Pinna, Marco; Tondo, Leonardo] Lucio Bini Mood Disorders Ctr, Via Cavalcanti 28, Rome, Italy.
   [Pinna, Marco; Manchia, Mirko] Univ Cagliari, Dept Med Sci & Publ Hlth, Sect Psychiat, Cagliari, Italy.
   [Manchia, Mirko] Dalhousie Univ, Dept Pharmacol, Halifax, NS, Canada.
   [Tondo, Leonardo; Baldessarini, Ross J.] Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA.
C3 University of Padua; Harvard University; Harvard University Medical
   Affiliates; McLean Hospital; University of Cagliari; Dalhousie
   University; Harvard University; Harvard Medical School
RP Tondo, L (corresponding author), Ctr Lucio Bini, Via Cavalcanti 28, Cagliari, Italy.
EM Ltondo@aol.com
RI Miola, Alessandro/LMP-0749-2024; Baldessarini, Ross/ADO-8296-2022;
   Manchia, Mirko/A-2907-2010
FU Aretaeus Foundation of Rome; Bruce J. Anderson Foundation; McLean
   Private Donors Psychiatry Research Fund
FX Supported by a grant from the Aretaeus Foundation of Rome (to LT), and a
   grant from the Bruce J. Anderson Foundation and the McLean Private
   Donors Psychiatry Research Fund (to RJB).
CR Allison DB, 2009, AM J PREV MED, V36, P341, DOI 10.1016/j.amepre.2008.11.020
   Amare AT, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/tp.2016.261
   [Anonymous], WHO - Body mass index
   Atlantis E, 2008, INT J OBESITY, V32, P715, DOI 10.1038/sj.ijo.0803762
   Baio Jon, 2012, Morbidity and Mortality Weekly Report, V61, P1
   Baldessarini RJ., 2013, CHEMOTHERAPY PSYCHIA, VThird
   Belanoff JK, 2001, AM J PSYCHIAT, V158, P1612, DOI 10.1176/appi.ajp.158.10.1612
   Beydoun MA, 2010, J AFFECT DISORDERS, V123, P52, DOI 10.1016/j.jad.2009.09.021
   Birur B, 2017, FRONT PSYCHIATRY, V8, DOI 10.3389/fpsyt.2017.00108
   Bond DJ, 2019, BIPOLAR DISORD, V21, P50, DOI 10.1111/bdi.12722
   Bromberger JT, 2010, ARCH GEN PSYCHIAT, V67, P598, DOI 10.1001/archgenpsychiatry.2010.55
   Brumpton B, 2013, INT J OBESITY, V37, P1268, DOI 10.1038/ijo.2012.204
   Busetta Giovanni, 2018, Genus, V74, P4, DOI 10.1186/s41118-018-0030-1
   Calkin C, 2009, BIPOLAR DISORD, V11, P650, DOI 10.1111/j.1399-5618.2009.00730.x
   Carey M, 2014, BRIT J GEN PRACT, V64, pE122, DOI 10.3399/bjgp14X677482
   Chouinard VA, 2016, PSYCHIAT RES, V237, P304, DOI 10.1016/j.psychres.2016.01.024
   Correll CU, 2015, WORLD PSYCHIATRY, V14, P119, DOI 10.1002/wps.20204
   de Carvalho-Ferreira JP, 2015, PEPTIDES, V65, P20, DOI 10.1016/j.peptides.2014.11.010
   de Wit L, 2010, PSYCHIAT RES, V178, P230, DOI 10.1016/j.psychres.2009.04.015
   Devaux M., 2011, OECD Econ Stud, V2011, P1, DOI [DOI 10.1787/ECO_STUDIES-2011-5KG5825V1K23, DOI 10.1787/ECOSTUDIES-2011-5KG5825V1K23, 10.1787/ecostudies-2011-5kg5825v1k23]
   Dreimüller N, 2019, J AFFECT DISORDERS, V256, P524, DOI 10.1016/j.jad.2019.06.067
   Elmslie JL, 2001, J CLIN PSYCHIAT, V62, P486, DOI 10.4088/JCP.v62n0614
   Everson SA, 2002, J PSYCHOSOM RES, V53, P891, DOI 10.1016/S0022-3999(02)00303-3
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   Fagiolini A, 2004, J CLIN PSYCHIAT, V65, P509
   Fagiolini A, 2003, AM J PSYCHIAT, V160, P112, DOI 10.1176/appi.ajp.160.1.112
   Forte A, 2015, J AFFECT DISORDERS, V178, P71, DOI 10.1016/j.jad.2015.02.011
   Garber CE, 2019, CURR SPORT MED REP, V18, P287, DOI 10.1249/JSR.0000000000000619
   Garcia-Portilla MP, 2008, J AFFECT DISORDERS, V106, P197, DOI 10.1016/j.jad.2007.06.002
   Gariepy G, 2010, INT J OBESITY, V34, P407, DOI 10.1038/ijo.2009.252
   Gianfredi V, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17103738
   Gill H, 2020, OBESITY, V28, P2064, DOI 10.1002/oby.22969
   Goldstein BI, 2011, BIPOLAR DISORD, V13, P387, DOI 10.1111/j.1399-5618.2011.00932.x
   Green E., 2017, Pers Med Psychiatry, V1-2, P65
   Hagenaars SP, 2020, AM J MED GENET B, V183, P309, DOI 10.1002/ajmg.b.32807
   Hasler G, 2004, PSYCHOL MED, V34, P1047, DOI 10.1017/S0033291703001697
   Holsboer F, 2000, NEUROPSYCHOPHARMACOL, V23, P477, DOI 10.1016/S0893-133X(00)00159-7
   Iniesta R, 2016, J PSYCHIATR RES, V78, P94, DOI 10.1016/j.jpsychires.2016.03.016
   ISS (Istituto Superiore di Sanita), 2017, EP SAN PUBBL OB DAT
   Jensen, 2014, CIRCULATION, V129, pS139, DOI 10.1161/CIR.0000000000000070
   Jha MK, 2018, J AFFECT DISORDERS, V234, P34, DOI 10.1016/j.jad.2018.02.089
   Kemp DE, 2014, J AFFECT DISORDERS, V169, pS34, DOI 10.1016/S0165-0327(14)70007-2
   Kemp DE, 2010, BIPOLAR DISORD, V12, P404, DOI 10.1111/j.1399-5618.2010.00823.x
   Khan A, 2007, J AFFECT DISORDERS, V99, P101, DOI 10.1016/j.jad.2006.08.027
   Kloiber S, 2007, BIOL PSYCHIAT, V62, P321, DOI 10.1016/j.biopsych.2006.10.001
   Lasserre AM, 2014, JAMA PSYCHIAT, V71, P880, DOI 10.1001/jamapsychiatry.2014.411
   Li L, 2017, FRONT ENDOCRINOL, V8, DOI 10.3389/fendo.2017.00292
   Lin CH, 2014, J AFFECT DISORDERS, V161, P123, DOI 10.1016/j.jad.2014.02.039
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   McElroy SL, 2016, ACTA PSYCHIAT SCAND, V133, P144, DOI 10.1111/acps.12460
   McIntyre Roger S, 2015, Prim Care Companion CNS Disord, V17, DOI 10.4088/PCC.14m01741
   McIntyre RS, 2006, CAN J PSYCHIAT, V51, P274, DOI 10.1177/070674370605100502
   Milaneschi Y, 2019, MOL PSYCHIATR, V24, P18, DOI 10.1038/s41380-018-0017-5
   Morris G, 2019, NEUROSCI BIOBEHAV R, V107, P862, DOI 10.1016/j.neubiorev.2019.09.025
   OECD, 2017, Education ata Glance
   Ösby U, 2001, ARCH GEN PSYCHIAT, V58, P844, DOI 10.1001/archpsyc.58.9.844
   Oskooilar N, 2009, J CLIN PSYCHIAT, V70, P1609, DOI 10.4088/JCP.09l05226blu
   Palinkas LA, 1996, J PSYCHOSOM RES, V40, P59, DOI 10.1016/0022-3999(95)00542-0
   Papadopoulos S, 2015, OBESITY, V23, P1743, DOI 10.1002/oby.21187
   Papakostas GI, 2005, INT J NEUROPSYCHOPH, V8, P59, DOI 10.1017/S1461145704004602
   Pasquali R, 2000, INT J OBESITY, V24, pS47, DOI 10.1038/sj.ijo.0801277
   Peters AT, 2016, AUST NZ J PSYCHIAT, V50, P667, DOI 10.1177/0004867415616694
   Phelan SM, 2015, OBES REV, V16, P319, DOI 10.1111/obr.12266
   Pi-Sunyer FX, 1998, OBES RES, V6, p51S
   Puhl RM, 2009, OBESITY, V17, P941, DOI 10.1038/oby.2008.636
   Puzhko S, 2020, J AFFECT DISORDERS, V267, P153, DOI 10.1016/j.jad.2020.01.113
   Rege S, 2008, AUST NZ J PSYCHIAT, V42, P369, DOI 10.1080/00048670801961123
   Rivera M, 2019, EUR PSYCHIAT, V60, P20, DOI 10.1016/j.eurpsy.2019.04.008
   Sander C, 2018, EAT WEIGHT DISORD-ST, V23, P195, DOI 10.1007/s40519-016-0347-8
   Schuch F, 2017, J AFFECT DISORDERS, V210, P139, DOI 10.1016/j.jad.2016.10.050
   Shah Amy, 2006, Ann Clin Psychiatry, V18, P239, DOI 10.1080/10401230600948423
   Sikorski C, 2016, INT J OBESITY, V40, P333, DOI 10.1038/ijo.2015.165
   Simon GE, 2008, GEN HOSP PSYCHIAT, V30, P32, DOI 10.1016/j.genhosppsych.2007.09.001
   Simon GE, 2006, ARCH GEN PSYCHIAT, V63, P824, DOI 10.1001/archpsyc.63.7.824
   Soczynska JK, 2011, NEUROMOL MED, V13, P93, DOI 10.1007/s12017-010-8140-8
   Strawbridge RJ, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-020-79964-x
   Taylor VH, 2012, CAN J PSYCHIAT, V57, P5, DOI 10.1177/070674371205700103
   Toups MSP, 2013, PSYCHOSOM MED, V75, P863, DOI 10.1097/PSY.0000000000000000
   Uher R, 2009, J AFFECT DISORDERS, V118, P147, DOI 10.1016/j.jad.2009.02.013
   Vancampfort D, 2017, WORLD PSYCHIATRY, V16, P308, DOI 10.1002/wps.20458
   Vancampfort D, 2015, J CLIN PSYCHIAT, V76, P1490, DOI 10.4088/JCP.14r09635
   Vancampfort D, 2012, PSYCHIAT RES, V200, P73, DOI 10.1016/j.psychres.2012.03.046
   Wang PW, 2006, J PSYCHIATR RES, V40, P762, DOI 10.1016/j.jpsychires.2006.01.007
   WILLIAMS JBW, 1988, ARCH GEN PSYCHIAT, V45, P742
   Woo YS, 2016, J AFFECT DISORDERS, V203, P190, DOI 10.1016/j.jad.2016.06.018
   Woo YS, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17010080
   YOUNG RC, 1978, BRIT J PSYCHIAT, V133, P429, DOI 10.1192/bjp.133.5.429
   Zavala GA, 2018, SOC PSYCH PSYCH EPID, V53, P639, DOI 10.1007/s00127-018-1517-y
NR 88
TC 9
Z9 9
U1 0
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JAN 15
PY 2022
VL 297
BP 169
EP 175
DI 10.1016/j.jad.2021.10.032
EA OCT 2021
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA XO0CR
UT WOS:000729864000020
PM 34699849
DA 2025-06-11
ER

PT J
AU Rajan, TM
   Menon, V
AF Rajan, T. M.
   Menon, V
TI Psychiatric disorders and obesity: A review of association studies
SO JOURNAL OF POSTGRADUATE MEDICINE
LA English
DT Review
DE Anxiety; depression; metabolic syndrome; obesity; psychiatry; review
ID BODY-MASS INDEX; PATIENTS RECEIVING CLOZAPINE; METABOLIC SYNDROME;
   CHILDHOOD OVERWEIGHT; DEPRESSIVE SYMPTOMS; GENDER-DIFFERENCES; ANXIETY
   DISORDERS; ABDOMINAL OBESITY; MENTAL-DISORDERS; POPULATION
AB Background: Inconsistent evidence exists regarding the strength, direction, and moderators in the relationship between obesity and psychiatric disorders. Aim: This study aims to summarize the evidence on the association between psychiatric illness and obesity with particular attention to the strength and direction of association and also the possible moderators in each postulated link. Materials and Methods: Systematic electronic searches of MEDLINE through PubMed, ScienceDirect, PsycINFO, and Google Scholar were carried out from inception till October 2016. Generated abstracts were screened for eligibility to be included in the review. Study designs that evaluated the strength of relationship between obesity and psychiatric disorders were included in the study. Quality assessment of included studies was done using the NewcastleuOttawa checklist tool. Results: From a total of 2424 search results, 21 eligible articles were identified and reviewed. These included studies on obesity and depression (n = 15), obesity and anxiety (four) and one each on obesity and personality disorders, eating disorder (ED), attention deficit hyperactivity disorder, and alcohol use. Maximal evidence existed for the association between depression and obesity with longitudinal studies demonstrating a bidirectional link between the two conditions. The odds ratios (ORs) were similar for developing depression in obesity (OR: 1.21u5.8) and vice versa (OR: 1.18u3.76) with a stronger association observed in women. For anxiety disorders, evidence was mostly cross-sectional, and associations were of modest magnitude (OR: 1.27u1.40). Among other disorders, obesity, and EDs appear to have a close link (OR: 4.5). Alcohol use appears to be a risk factor for obesity and not vice versa but only among women (OR: 3.84). Conclusion: Obesity and depression have a significant and bidirectional association. Evidence is modest for anxiety disorders and inadequate for other psychiatric conditions. Gender appears to be an important mediator in these relationships.
C1 [Rajan, T. M.; Menon, V] Jawaharlal Inst Postgrad Med Educ & Res, Dept Psychiat, Pondicherry, India.
C3 Jawaharlal Institute of Postgraduate Medical Education & Research
RP Menon, V (corresponding author), Jawaharlal Inst Postgrad Med Educ & Res, Dept Psychiat, Pondicherry, India.
EM drvmenon@gmail.com
RI Menon, Vikas/F-3100-2012
CR Agarwal Sri Mahavir, 2013, Indian J Psychol Med, V35, P117, DOI 10.4103/0253-7176.116231
   Atlantis E, 2008, INT J OBESITY, V32, P881, DOI 10.1038/ijo.2008.54
   Barry D, 2008, ANN EPIDEMIOL, V18, P458, DOI 10.1016/j.annepidem.2007.12.009
   Beydoun MA, 2010, J AFFECT DISORDERS, V123, P52, DOI 10.1016/j.jad.2009.09.021
   Bhardwaj S, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024362
   Blaine B, 2008, J HEALTH PSYCHOL, V13, P1190, DOI 10.1177/1359105308095977
   Cortese S, 2013, BRIT J PSYCHIAT, V203, P24, DOI 10.1192/bjp.bp.112.123299
   Cortese S, 2013, PEDIATRICS, V131, pE1731, DOI 10.1542/peds.2012-0540
   Darby A, 2009, INT J EAT DISORDER, V42, P104, DOI 10.1002/eat.20601
   De Hert M, 2009, WORLD PSYCHIATRY, V8, P15
   de Wit L, 2010, PSYCHIAT RES, V178, P230, DOI 10.1016/j.psychres.2009.04.015
   Deepa M, 2009, EUR J CLIN NUTR, V63, P259, DOI 10.1038/sj.ejcn.1602920
   Ejike Chukwunonso Ecc, 2013, J Neurosci Rural Pract, V4, pS13, DOI 10.4103/0976-3147.116429
   FITZGIBBON ML, 1993, HEALTH PSYCHOL, V12, P342, DOI 10.1037/0278-6133.12.5.342
   Gariepy G, 2010, INT J OBESITY, V34, P407, DOI 10.1038/ijo.2009.252
   Ge XJ, 2006, DEV PSYCHOPATHOL, V18, P253, DOI 10.1017/S0954579406060147
   Gerlach G, 2016, OBES REV, V17, P691, DOI 10.1111/obr.12415
   Gerlach G, 2015, OBES REV, V16, P32, DOI 10.1111/obr.12235
   Grover S, 2011, INDIAN J PHARMACOL, V43, P591, DOI 10.4103/0253-7613.84979
   Guedes EP, 2013, DIABETOL METAB SYNDR, V5, DOI 10.1186/1758-5996-5-82
   Hansen T, 2011, BIOL PSYCHIAT, V70, P59, DOI 10.1016/j.biopsych.2011.01.031
   Herpertz S, 2006, J PSYCHOSOM RES, V61, P95, DOI 10.1016/j.jpsychores.2005.10.003
   Herva A, 2006, INT J OBESITY, V30, P520, DOI 10.1038/sj.ijo.0803174
   Hicken MT, 2013, J WOMENS HEALTH, V22, P445, DOI 10.1089/jwh.2012.4111
   Jüni P, 1999, JAMA-J AM MED ASSOC, V282, P1054, DOI 10.1001/jama.282.11.1054
   Kasen S, 2008, INT J OBESITY, V32, P558, DOI 10.1038/sj.ijo.0803736
   Kearns K, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-143
   Kenny PJ, 2011, NEURON, V69, P664, DOI 10.1016/j.neuron.2011.02.016
   Kim JY, 2010, J KOREAN MED SCI, V25, P1560, DOI 10.3346/jkms.2010.25.11.1560
   Kurhe Y, 2015, ASIAN J PSYCHIATR, V17, P3, DOI 10.1016/j.ajp.2015.07.007
   Labad J, 2010, DIABETOLOGIA, V53, P467, DOI 10.1007/s00125-009-1628-9
   Lamberti JS, 2006, AM J PSYCHIAT, V163, P1273, DOI 10.1176/appi.ajp.163.7.1273
   Laus MF, 2015, EAT BEHAV, V19, P159, DOI 10.1016/j.eatbeh.2015.09.003
   Lin HY, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-1
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Lykouras L, 2011, Psychiatriki, V22, P307
   Ma J, 2010, OBESITY, V18, P347, DOI 10.1038/oby.2009.213
   Malina RM, 2004, GROWTH MATURATION PH, P535
   Mannan M, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0157240
   Markowitz S, 2008, CLIN PSYCHOL-SCI PR, V15, P1, DOI 10.1111/j.1468-2850.2008.00106.x
   Marmorstein NR, 2014, INT J OBESITY, V38, P906, DOI 10.1038/ijo.2014.19
   McCarty CA, 2009, GEN HOSP PSYCHIAT, V31, P442, DOI 10.1016/j.genhosppsych.2009.05.013
   Mohan V, 2006, INDIAN J MED RES, V123, P593
   Must A, 1999, JAMA-J AM MED ASSOC, V282, P1523, DOI 10.1001/jama.282.16.1523
   Needham BL, 2005, J ADOLESCENT HEALTH, V36, P48, DOI 10.1016/j.jadohealth.2003.12.015
   Ogden CL, 2010, JAMA-J AM MED ASSOC, V303, P242, DOI 10.1001/jama.2009.2012
   Pan A, 2012, INT J OBESITY, V36, P595, DOI 10.1038/ijo.2011.111
   Pradeepa R, 2015, INDIAN J MED RES, V142, P139, DOI 10.4103/0971-5916.164234
   Raj M, 2010, INDIAN J MED RES, V132, P598
   Ranjani H, 2016, INDIAN J MED RES, V143, P160, DOI 10.4103/0971-5916.180203
   Richardson LP, 2003, ARCH PEDIAT ADOL MED, V157, P739, DOI 10.1001/archpedi.157.8.739
   ROSS CE, 1994, J HEALTH SOC BEHAV, V35, P63, DOI 10.2307/2137335
   Sacco WP, 2005, HEALTH PSYCHOL, V24, P630, DOI 10.1037/0278-6133.24.6.630
   Sansone Randy A, 2013, Innov Clin Neurosci, V10, P36
   Scott KA, 2008, J PSYCHOSOM RES, V64, P97, DOI 10.1016/j.jpsychores.2007.09.006
   Simon GE, 2006, ARCH GEN PSYCHIAT, V63, P824, DOI 10.1001/archpsyc.63.7.824
   Slyper AH, 2006, CLIN ENDOCRINOL, V65, P1, DOI 10.1111/j.1365-2265.2006.02539.x
   Stice E, 2013, NEUROSCI BIOBEHAV R, V37, P2047, DOI 10.1016/j.neubiorev.2012.12.001
   Sutin AR, 2011, J PERS SOC PSYCHOL, V101, P579, DOI 10.1037/a0024286
   Terracciano A, 2009, PSYCHOSOM MED, V71, P682, DOI 10.1097/PSY.0b013e3181a2925b
   VanBuskirk KA, 2010, J ADDICT MED, V4, P1, DOI 10.1097/ADM.0b013e3181ce38e7
   Venkatasubramanian G, 2007, AM J PSYCHIAT, V164, P1557, DOI 10.1176/appi.ajp.2007.07020233
   Volkow N D, 2012, Curr Top Behav Neurosci, V11, P1, DOI 10.1007/7854_2011_169
   Wang Y, 2006, INT J PEDIATR OBES, V1, P11, DOI 10.1080/17477160600586747
   Wells G.A., 2019, The Newcastle-OttawaScale (NOS) for assessing the quality of non randomized studies in meta-analyses
   Wong WCW, 2008, EMERG THEMES EPIDEMI, V5, DOI 10.1186/1742-7622-5-23
   World Health Organization, 2014, World Health Statistics 2014
   Zhao G, 2009, INT J OBESITY, V33, P257, DOI 10.1038/ijo.2008.268
   Zhong WJ, 2010, DEPRESS ANXIETY, V27, P846, DOI 10.1002/da.20666
NR 69
TC 249
Z9 274
U1 2
U2 24
PU MEDKNOW PUBLICATIONS & MEDIA PVT LTD
PI MUMBAI
PA B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075,
   INDIA
SN 0022-3859
J9 J POSTGRAD MED
JI J. Postgrad. Med.
PD JUL-SEP
PY 2017
VL 63
IS 3
BP 182
EP 190
DI 10.4103/jpgm.JPGM_712_16
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA FB1HM
UT WOS:000405894500009
PM 28695871
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Santos, CJ
   Ferreira, AVM
   Oliveira, AL
   Oliveira, MC
   Gomes, JS
   Aguiar, DC
AF Santos, Carla J.
   Ferreira, Adaliene V. M.
   Oliveira, Ana L.
   Oliveira, Marina C.
   Gomes, Julia S.
   Aguiar, Daniele C.
TI Carbohydrate-enriched diet predispose to anxiety and depression-like
   behavior after stress in mice
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Article
DE Anxiety; Depression; Carbohydrate diet; Stress
ID MOOD DISORDERS; ANIMAL-MODELS; LEPTIN ACTION; OBESITY;
   NEUROINFLAMMATION; INFLAMMATION; ACTIVATION; MECHANISMS; ADIPOKINES;
   REACTIVITY
AB Objectives: Obesity is a chronic disease frequently associated with serious co-morbidities, such as diabetes type II, metabolic syndrome, and psychiatric disorders. Little is known, however, regarding the behavioral consequences of modified diet constituents and the propensity to development of stress related disorders. Thus, the aim of this study was to verify whether chronic exposure to a normocaloric/high-carbohydrate diet will modify the animal's behavior after different stressful stimuli.
   Methods: BALB/c mice were fed for 12 weeks with a standard chow diet or high refined carbohydrate-containing diet (HC). Following this period, independent groups of animals were exposed to different stress paradigms: 1 - two hours of restraint stress followed by exposure to the Elevated Plus Maze test (EPM) 24 hours later; 2 - The contextual fear conditioning (CFC) test and 3 - the tail suspension test (TST).
   Results: Despite no change on total body weight, animals fed with HC diet showed increase in serum leptin levels and higher adiposity compared to diet control group. In behavioral tests, animals from HC diet group displayed reduction in the percentage of entries into the open arms of the EPM, evaluated 24 hours after restraint stress, suggesting an anxiogenic-like effect. It is also observed increase in aversive memory in the CFC test and depressive-like behavior in TST.
   Discussion: Our results suggest that a moderate obesity, induced by high refined carbohydrate diet, may facilitate the development of anxiety and depressive-like behaviors after the stress. The mechanisms responsible for such effects remain to be elucidated.
C1 [Santos, Carla J.; Oliveira, Ana L.; Gomes, Julia S.; Aguiar, Daniele C.] Univ Fed Minas Gerais, Inst Biol Sci ICB, Dept Pharmacol, Av Pres Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil.
   [Ferreira, Adaliene V. M.; Oliveira, Marina C.] Univ Fed Minas Gerais, Nursing Sch, Dept Nutr, Belo Horizonte, MG, Brazil.
C3 Universidade Federal de Minas Gerais; Universidade Federal de Minas
   Gerais
RP Aguiar, DC (corresponding author), Univ Fed Minas Gerais, Inst Biol Sci ICB, Dept Pharmacol, Av Pres Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil.
EM danieleaguiar@ufmg.br
RI Aguiar, Daniele/F-9494-2018; Ferreira, adaliene/G-8523-2011; Chaves de
   Oliveira, Marina/E-7895-2018
OI Ferreira, adaliene/0000-0003-2256-8652; De Aguiar, Daniele
   Cristina/0000-0001-7635-8656; Chaves de Oliveira,
   Marina/0000-0002-7423-9802
FU Capes; CNPq [477541/2012-7]
FX The authors would like to thanks the financial support from Capes and
   CNPq (477541/2012-7).
CR Aguilar-Valles A, 2015, NEUROPHARMACOLOGY, V96, P124, DOI 10.1016/j.neuropharm.2014.12.023
   Aguliar-Valles A, 2014, MOL PSYCHIATR, V19, P599, DOI 10.1038/mp.2013.137
   André C, 2014, BRAIN BEHAV IMMUN, V41, P10, DOI 10.1016/j.bbi.2014.03.012
   [Anonymous], 2015, OB OV
   Arnoldussen IAC, 2014, EUR NEUROPSYCHOPHARM, V24, P1982, DOI 10.1016/j.euroneuro.2014.03.002
   Asakawa A, 2003, J DIABETES COMPLICAT, V17, P105, DOI 10.1016/S1056-8727(02)00185-X
   Aslani S, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.178
   Block JP, 2009, AM J EPIDEMIOL, V170, P181, DOI 10.1093/aje/kwp104
   Brydon L, 2011, BIOL PSYCHOL, V86, P114, DOI 10.1016/j.biopsycho.2010.02.010
   Buchenauer T, 2009, PHYSIOL BEHAV, V98, P563, DOI 10.1016/j.physbeh.2009.09.003
   Cai DS, 2013, TRENDS ENDOCRIN MET, V24, P40, DOI 10.1016/j.tem.2012.11.003
   Castanon N, 2015, FRONT NEUROSCI-SWITZ, V9, DOI 10.3389/fnins.2015.00229
   Castanon N, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00074
   Cryan JF, 2007, CURR OPIN PSYCHIATR, V20, P1, DOI 10.1097/YCO.0b013e3280117733
   Dallman MF, 2003, P NATL ACAD SCI USA, V100, P11696, DOI 10.1073/pnas.1934666100
   De Vriendt T, 2009, NUTR METAB CARDIOVAS, V19, P511, DOI 10.1016/j.numecd.2009.02.009
   Del Rosario A, 2012, BRIT J NUTR, V108, P1143, DOI 10.1017/S0007114511006738
   Dutheil S, 2016, NEUROPSYCHOPHARMACOL, V41, P1874, DOI 10.1038/npp.2015.357
   Evans DL, 2005, BIOL PSYCHIAT, V58, P175, DOI 10.1016/j.biopsych.2005.05.001
   Finger BC, 2010, PSYCHOPHARMACOLOGY, V210, P559, DOI 10.1007/s00213-010-1858-z
   Gariepy G, 2010, INT J OBESITY, V34, P407, DOI 10.1038/ijo.2009.252
   Haleem DJ, 2014, BEHAV PHARMACOL, V25, P384, DOI 10.1097/FBP.0000000000000050
   Hryhorczuk C, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00177
   Jauch-Chara K, 2014, PROG NEUROBIOL, V114, P84, DOI 10.1016/j.pneurobio.2013.12.001
   Kurhe Y, 2014, METAB BRAIN DIS, V29, P701, DOI 10.1007/s11011-014-9574-8
   Lee EB, 2014, ACTA NEUROPATHOL, V127, P3, DOI 10.1007/s00401-013-1190-x
   Lisboa SF, 2015, INT J NEUROPSYCHOPH, V18, DOI 10.1093/ijnp/pyv005
   Liu J, 2010, PSYCHOPHARMACOLOGY, V207, P535, DOI 10.1007/s00213-009-1684-3
   Lopresti AL, 2013, PROG NEURO-PSYCHOPH, V45, P92, DOI 10.1016/j.pnpbp.2013.05.005
   Mansur RB, 2015, NEUROSCI BIOBEHAV R, V52, P89, DOI 10.1016/j.neubiorev.2014.12.017
   Martyn JAJ, 2008, ANESTHESIOLOGY, V109, P137, DOI 10.1097/ALN.0b013e3181799d45
   McEwen BS, 2015, NAT NEUROSCI, V18, P1353, DOI 10.1038/nn.4086
   Miller AA, 2014, BRAIN BEHAV IMMUN, V42, P10, DOI 10.1016/j.bbi.2014.04.001
   Mujica-Parodi LR, 2009, INT J OBESITY, V33, P157, DOI 10.1038/ijo.2008.218
   Murphy M, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/701967
   Myers MG, 2008, ANNU REV PHYSIOL, V70, P537, DOI 10.1146/annurev.physiol.70.113006.100707
   Nollet M., 2013, Curr. Protoc. Pharmacol., P1, DOI [DOI 10.1002/0471141755.PH0565-61, 10.1002/0471141755.ph0565s61., DOI 10.1002/0471141755.PH0565S61, 10.1002/0471141755.ph0565s61]
   O'Leary TP, 2013, BEHAV GENET, V43, P34, DOI 10.1007/s10519-012-9572-8
   O'Mahony CM, 2010, BEHAV BRAIN RES, V213, P148, DOI 10.1016/j.bbr.2010.04.038
   Oliveira MC, 2013, OBESITY, V21, pE396, DOI [10.1038/oby.20230, 10.1002/oby.20230]
   Padovan CM, 2000, BRAZ J MED BIOL RES, V33, P79, DOI 10.1590/S0100-879X2000000100011
   PELLOW S, 1985, J NEUROSCI METH, V14, P149, DOI 10.1016/0165-0270(85)90031-7
   Réus GZ, 2015, NEUROSCIENCE, V300, P141, DOI 10.1016/j.neuroscience.2015.05.018
   Sharma S, 2013, INT J OBESITY, V37, P382, DOI 10.1038/ijo.2012.48
   Siegmund A, 2006, ANN NY ACAD SCI, V1071, P324, DOI 10.1196/annals.1364.025
   Sinha R, 2013, BIOL PSYCHIAT, V73, P827, DOI 10.1016/j.biopsych.2013.01.032
   Souza CG, 2007, LIFE SCI, V81, P198, DOI 10.1016/j.lfs.2007.05.001
   STERU L, 1985, PSYCHOPHARMACOLOGY, V85, P367, DOI 10.1007/BF00428203
   Torres SJ, 2007, NUTRITION, V23, P887, DOI 10.1016/j.nut.2007.08.008
   Trayhurn P, 2006, J NUTR, V136, p1935S, DOI 10.1093/jn/136.7.1935S
   Wang W, 2015, CNS NEUROSCI THER, V21, P425, DOI 10.1111/cns.12375
   Yamada N, 2011, ENDOCRINOLOGY, V152, P2634, DOI 10.1210/en.2011-0004
   Yamada-Goto N, 2012, J NEUROENDOCRINOL, V24, P1120, DOI 10.1111/j.1365-2826.2012.02327.x
NR 53
TC 32
Z9 33
U1 4
U2 30
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1028-415X
EI 1476-8305
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PY 2018
VL 21
IS 1
BP 33
EP 39
DI 10.1080/1028415X.2016.1213529
PG 7
WC Neurosciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Nutrition & Dietetics
GA FR9MI
UT WOS:000419397400004
PM 27472404
DA 2025-06-11
ER

PT J
AU Correll, CU
   Robinson, DG
   Schooler, NR
   Brunette, MF
   Mueser, KT
   Rosenheck, RA
   Marcy, P
   Addington, J
   Estroff, SE
   Robinson, J
   Penn, DL
   Azrin, S
   Goldstein, A
   Severe, J
   Heinssen, R
   Kane, JM
AF Correll, Christoph U.
   Robinson, Delbert G.
   Schooler, Nina R.
   Brunette, Mary F.
   Mueser, Kim T.
   Rosenheck, Robert A.
   Marcy, Patricia
   Addington, Jean
   Estroff, Sue E.
   Robinson, James
   Penn, David L.
   Azrin, Susan
   Goldstein, Amy
   Severe, Joanne
   Heinssen, Robert
   Kane, John M.
TI Cardiometabolic Risk in Patients With First-Episode Schizophrenia
   Spectrum Disorders Baseline Results From the RAISE-ETP Study
SO JAMA PSYCHIATRY
LA English
DT Article
ID NUTRITION EXAMINATION SURVEY; 3RD NATIONAL-HEALTH; DENSITY-LIPOPROTEIN
   CHOLESTEROL; FASTING PLASMA-GLUCOSE; METABOLIC SYNDROME; UNITED-STATES;
   SCHIZOAFFECTIVE DISORDER; ANTIPSYCHOTIC-DRUGS; CARDIOVASCULAR RISK;
   PHYSICAL ILLNESS
AB IMPORTANCE The fact that individuals with schizophrenia have high cardiovascular morbidity and mortality is well established. However, risk status and moderators or mediators in the earliest stages of illness are less clear. OBJECTIVE To assess cardiometabolic risk in first-episode schizophrenia spectrum disorders (FES) and its relationship to illness duration, antipsychotic treatment duration and type, sex, and race/ethnicity.
   DESIGN, SETTING, AND PARTICIPANTS Baseline results of the Recovery After an Initial Schizophrenia Episode (RAISE) study, collected between July 22, 2010, and July 5, 2012, from 34 community mental health facilities without major research, teaching, or clinical FES programs. Patients were aged 15 to 40 years, had research-confirmed diagnoses of FES, and had less than 6 months of lifetime antipsychotic treatment.
   EXPOSURE Prebaseline antipsychotic treatment was based on the community clinician's and/or patient's decision.
   MAIN OUTCOMES AND MEASURES Body composition and fasting lipid, glucose, and insulin parameters.
   RESULTS In 394 of 404 patients with cardiometabolic data (mean [SD] age, 23.6 [5.0] years; mean [SD] lifetime antipsychotic treatment, 47.3 [46.1] days), 48.3% were obese or overweight, 50.8% smoked, 56.5% had dyslipidemia, 39.9% had prehypertension, 10.0% had hypertension, and 13.2% had metabolic syndrome. Prediabetes (glucose based, 4.0%; hemoglobin A(1c) based, 15.4%) and diabetes (glucose based, 3.0%; hemoglobin A1c based, 2.9%) were less frequent. Total psychiatric illness duration correlated significantly with higher body mass index, fat mass, fat percentage, and waist circumference (all P < .01) but not elevated metabolic parameters (except triglycerides to HDL-C ratio [P = .04]). Conversely, antipsychotic treatment duration correlated significantly with higher non-HDL-C, triglycerides, and triglycerides to HDL-C ratio and lower HDL-C and systolic blood pressure (all P <= .01). Olanzapine was significantly associated with higher triglycerides, insulin, and insulin resistance, whereas quetiapine fumarate was associated with significantly higher triglycerides to HDL-C ratio (all P <= .02).
   CONCLUSIONS AND RELEVANCE In patients with FES, cardiometabolic risk factors and abnormalities are present early in the illness and likely related to the underlying illness, unhealthy lifestyle, and antipsychotic medications, which interact with each other. Prevention of and early interventions for psychiatric illness and treatment with lower-risk agents, routine antipsychotic adverse effect monitoring, and smoking cessation interventions are needed from the earliest illness phases.
C1 [Correll, Christoph U.; Robinson, Delbert G.; Schooler, Nina R.; Marcy, Patricia; Kane, John M.] Zucker Hillside Hosp, North Shore LIJ Hlth Syst, Div Psychiat Res, Glen Oaks, NY 11004 USA.
   [Correll, Christoph U.; Robinson, Delbert G.; Marcy, Patricia; Kane, John M.] Feinstein Inst Med Res, Manhasset, NY USA.
   [Correll, Christoph U.; Robinson, Delbert G.; Robinson, James; Kane, John M.] Hofstra North Shore LIJ Sch Med, Hempstead, NY USA.
   [Correll, Christoph U.; Robinson, Delbert G.; Kane, John M.] Albert Einstein Coll Med, Bronx, NY 10467 USA.
   [Schooler, Nina R.] Suny Downstate Med Ctr, New York, NY USA.
   [Brunette, Mary F.] Geisel Sch Med Dartmouth, Hanover, NH USA.
   [Brunette, Mary F.] Dept Hlth & Human Serv, Bur Behav Hlth, Hanover, NH USA.
   [Mueser, Kim T.] Boston Univ, Ctr Psychiat Rehabil, Dept Occupat Therapy, Boston, MA 02215 USA.
   [Mueser, Kim T.] Boston Univ, Ctr Psychiat Rehabil, Dept Psychiat, Boston, MA 02215 USA.
   [Mueser, Kim T.] Boston Univ, Ctr Psychiat Rehabil, Dept Psychol, Boston, MA 02215 USA.
   [Rosenheck, Robert A.] Yale Univ, Dept Psychiat & Epidemiol, Princeton, NJ USA.
   [Rosenheck, Robert A.] Yale Univ, Dept Publ Hlth, Princeton, NJ USA.
   [Addington, Jean] Univ Calgary, Hotchkiss Brain Inst, Dept Psychiat, Calgary, AB, Canada.
   [Estroff, Sue E.] Univ N Carolina, Dept Social Med, Chapel Hill, NC USA.
   [Robinson, James] Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA.
   [Penn, David L.] Univ N Carolina, Dept Psychol, Chapel Hill, NC USA.
   [Azrin, Susan; Goldstein, Amy; Severe, Joanne; Heinssen, Robert] NIMH, Bethesda, MD 20892 USA.
C3 Northwell Health; Northwell Health; Hofstra University; Northwell
   Health; Montefiore Medical Center; Albert Einstein College of Medicine;
   Yeshiva University; State University of New York (SUNY) System; SUNY
   Downstate Health Sciences University; Dartmouth College; Boston
   University; Boston University; Boston University; Yale University; Yale
   University; University of Calgary; University of North Carolina;
   University of North Carolina Chapel Hill; Nathan Kline Institute for
   Psychiatric Research; University of North Carolina; University of North
   Carolina Chapel Hill; National Institutes of Health (NIH) - USA; NIH
   National Institute of Mental Health (NIMH)
RP Correll, CU (corresponding author), Zucker Hillside Hosp, North Shore LIJ Hlth Syst, Div Psychiat Res, 75-59 263rd St, Glen Oaks, NY 11004 USA.
EM ccorrell@lij.edu
RI Schooler, Nina/M-4965-2017; Penn, David/AFT-9440-2022; Kane,
   Jeremy/JTU-1481-2023; Estroff, Sue/AAA-1300-2021; Heinssen,
   Robert/ACV-7271-2022; Robinson, Jim/D-9096-2016; Correll,
   Christoph/D-3530-2011; Addington, Jean/ACR-3912-2022
OI Kane, John/0000-0002-2628-9442; Brunette, Mary/0000-0002-0713-8745;
   Penn, David/0000-0003-4567-0166
FU National Institute of Mental Health [HHSN-271-2009-00019C]; American
   Recovery and Reinvestment Act
FX This work was supported in part by grant HHSN-271-2009-00019C from the
   National Institute of Mental Health (Dr Kane) and by federal funds from
   the American Recovery and Reinvestment Act.
CR Adhikari B., 2008, Morbidity and Mortality Weekly Report, V57, P1226
   [Anonymous], International, DOI DOI 10.2337/dc10-S011
   Buchanan RW, 2010, SCHIZOPHRENIA BULL, V36, P71, DOI 10.1093/schbul/sbp116
   Caemmerer J, 2012, SCHIZOPHR RES, V140, P159, DOI 10.1016/j.schres.2012.03.017
   Capasso RM, 2008, SCHIZOPHR RES, V98, P287, DOI 10.1016/j.schres.2007.10.005
   Chang CK, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019590
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   Colton Craig W, 2006, Prev Chronic Dis, V3, pA42
   Cook S, 2003, ARCH PEDIAT ADOL MED, V157, P821, DOI 10.1001/archpedi.157.8.821
   Correll CU, 2010, EUR PSYCHIAT, V25, pS12, DOI 10.1016/S0924-9338(10)71701-6
   Correll CU, 2008, INT REV PSYCHIATR, V20, P195, DOI 10.1080/09540260801889179
   Correll CU, 2007, SCHIZOPHR RES, V92, P103, DOI 10.1016/j.schres.2007.01.004
   Correll CU, 2011, TRENDS MOL MED, V17, P97, DOI 10.1016/j.molmed.2010.10.010
   Correll Christoph U, 2010, Psychiatr Serv, V61, P892, DOI 10.1176/ps.2010.61.9.892
   Correll CU, 2009, JAMA-J AM MED ASSOC, V302, P1765, DOI 10.1001/jama.2009.1549
   Crews DC, 2010, HYPERTENSION, V55, P1102, DOI 10.1161/HYPERTENSIONAHA.110.150722
   Critchley JA, 2003, JAMA-J AM MED ASSOC, V290, P86, DOI 10.1001/jama.290.1.86
   Cullen BA, 2013, SCHIZOPHRENIA BULL, V39, P1159, DOI 10.1093/schbul/sbs097
   Daviglus ML, 2012, JAMA-J AM MED ASSOC, V308, P1775, DOI 10.1001/jama.2012.14517
   De Hert M, 2011, BRIT J PSYCHIAT, V199, P99, DOI 10.1192/bjp.bp.110.084665
   Hert M, 2012, NAT REV ENDOCRINOL, V8, P114, DOI 10.1038/nrendo.2011.156
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P138
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   Doll R, 2004, BMJ-BRIT MED J, V328, P1519, DOI 10.1136/bmj.38142.554479.AE
   Druss BG, 2011, MED CARE, V49, P599, DOI 10.1097/MLR.0b013e31820bf86e
   Fenelon A, 2013, SOC SCI MED, V82, P1, DOI 10.1016/j.socscimed.2012.12.028
   First M.B., 2016, Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version
   Fleischhacker WW, 2013, INT J NEUROPSYCHOPH, V16, P987, DOI 10.1017/S1461145712001241
   Foley DL, 2011, ARCH GEN PSYCHIAT, V68, P609, DOI 10.1001/archgenpsychiatry.2011.2
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   GARRISON RJ, 1985, ANN INTERN MED, V103, P1006, DOI 10.7326/0003-4819-103-6-1006
   Gfroerer J, 2013, MMWR-MORBID MORTAL W, V62, P81
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   HEATHERTON TF, 1991, BRIT J ADDICT, V86, P1119
   Heianza Y, 2011, LANCET, V378, P147, DOI 10.1016/S0140-6736(11)60472-8
   Hoang U, 2013, ACTA PSYCHIAT SCAND, V127, P195, DOI 10.1111/acps.12045
   Hoang U, 2011, BMJ-BRIT MED J, V343, DOI 10.1136/bmj.d5422
   Kahn RS, 2008, LANCET, V371, P1085, DOI 10.1016/S0140-6736(08)60486-9
   Kane JM, 2010, J CLIN PSYCHIAT, V71, P1115, DOI 10.4088/JCP.10r06264yel
   Keyes KM, 2010, SOC SCI MED, V70, P1100, DOI 10.1016/j.socscimed.2009.12.018
   Kinon BJ, 2008, J CLIN PSYCHOPHARM, V28, P601, DOI 10.1097/JCP.0b013e31818aaf6c
   Lahti M, 2012, PSYCHOL MED, V42, P2275, DOI 10.1017/S0033291712000396
   Laursen TM, 2007, J CLIN PSYCHIAT, V68, P899, DOI 10.4088/JCP.v68n0612
   Li CY, 2008, CARDIOVASC DIABETOL, V7, DOI 10.1186/1475-2840-7-4
   Lieberman JA, 2005, NEW ENGL J MED, V353, P1209, DOI 10.1056/NEJMoa051688
   Lin SX, 2011, METAB SYNDR RELAT D, V9, P35, DOI 10.1089/met.2010.0050
   Manu P, 2013, EUR NEUROPSYCHOPHARM, V23, P205, DOI 10.1016/j.euroneuro.2012.05.002
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McClave AK, 2010, AM J PUBLIC HEALTH, V100, P2464, DOI 10.2105/AJPH.2009.188136
   McEvoy JP, 2007, AM J PSYCHIAT, V164, P1050, DOI 10.1176/appi.ajp.164.7.1050
   McLaughlin T, 2005, AM J CARDIOL, V96, P399, DOI 10.1016/j.amjcard.2005.03.085
   Mitchell AJ, 2012, PSYCHOL MED, V42, P125, DOI 10.1017/S003329171100105X
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P295, DOI 10.1093/schbul/sbs082
   Mitchell AJ, 2012, BRIT J PSYCHIAT, V201, P435, DOI 10.1192/bjp.bp.111.094532
   Mitchell AJ, 2010, J PSYCHOPHARMACOL, V24, P69, DOI 10.1177/1359786810382056
   Moreno C, 2010, BIPOLAR DISORD, V12, P172, DOI 10.1111/j.1399-5618.2010.00797.x
   Mucha Lisa, 2006, Gend Med, V3, P279, DOI 10.1016/S1550-8579(06)80216-0
   Nasrallah HA, 2006, SCHIZOPHR RES, V86, P15, DOI 10.1016/j.schres.2006.06.026
   Nielsen J, 2010, NEUROPSYCHOPHARMACOL, V35, P1997, DOI 10.1038/npp.2010.78
   Nielsen RE, 2013, SCHIZOPHR RES, V146, P22, DOI 10.1016/j.schres.2013.02.025
   Nordentoft M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055176
   Ösby U, 2000, BRIT MED J, V321, P483, DOI 10.1136/bmj.321.7259.483
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Perez-Iglesias R, 2007, J CLIN PSYCHIAT, V68, P1733, DOI 10.4088/JCP.v68n1113
   Ratliff JC, 2013, PSYCHOSOMATICS, V54, P67, DOI 10.1016/j.psym.2012.03.001
   Saha S, 2007, ARCH GEN PSYCHIAT, V64, P1123, DOI 10.1001/archpsyc.64.10.1123
   Selvin E, 2011, ANN INTERN MED, V154, DOI 10.7326/0003-4819-154-5-201103010-00004
   Sentell TL, 2012, ETHNIC DIS, V22, P451
   Srihari VH, 2013, SCHIZOPHR RES, V146, P64, DOI 10.1016/j.schres.2013.01.014
   Stringhini S, 2010, JAMA-J AM MED ASSOC, V303, P1159, DOI 10.1001/jama.2010.297
   Sumner Anne E, 2010, CVD Prev Control, V5, P75
   Suvisaari J, 2013, PSYCHOSOM MED, V75, P60, DOI 10.1097/PSY.0b013e31827ad512
   Tiihonen J, 2009, LANCET, V374, P620, DOI 10.1016/S0140-6736(09)60742-X
   Tirosh A, 2011, NEW ENGL J MED, V364, P1315, DOI 10.1056/NEJMoa1006992
   Tóth PP, 2012, J CLIN LIPIDOL, V6, P325, DOI 10.1016/j.jacl.2012.05.002
   Tsai KY, 2012, SCHIZOPHR RES, V138, P41, DOI 10.1016/j.schres.2012.02.013
   Tsugawa Y, 2012, ANN INTERN MED, V157, P153, DOI 10.7326/0003-4819-157-3-201208070-00004
   Yu SSK, 2012, METAB SYNDR RELAT D, V10, P77, DOI 10.1089/met.2011.0108
   Ziemer DC, 2010, ANN INTERN MED, V152, P770, DOI 10.7326/0003-4819-152-12-201006150-00004
NR 79
TC 318
Z9 335
U1 4
U2 62
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-622X
EI 2168-6238
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD DEC
PY 2014
VL 71
IS 12
BP 1350
EP 1363
DI 10.1001/jamapsychiatry.2014.1314
PG 14
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AU9MQ
UT WOS:000345917900007
PM 25321337
DA 2025-06-11
ER

PT J
AU Lee, SH
   Shin, C
   Ko, YH
   Lee, MS
   Park, MH
   Pae, CU
   Yoon, HK
   Han, C
AF Lee, Seung-Hoon
   Shin, Cheolmin
   Ko, Young-Hoon
   Lee, Moon -Soo
   Park, Moon Ho
   Pae, Chi-Un
   Yoon, Ho-Kyoung
   Han, Changsu
TI Plasminogen Activator Inhibitor-1: Potential Inflammatory Marker in
   Late-life Depression
SO CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
LA English
DT Article
DE Depression; Plasminogen activator inhibitor 1; Adipokine; Inflammation;
   Metabolic syndrome
ID METABOLIC SYNDROME; INSULIN SENSITIVITY; CARDIOVASCULAR RISK; GRADE
   INFLAMMATION; KOREAN VERSION; SERUM-LEVELS; ADIPONECTIN; OBESITY; BRAIN;
   BIOMARKER
AB Objective: Although several previous studies have examined the association between late-life depression and blood adipokine levels, a marker of chronic inflammation, no studies have comprehensively considered the effects of metabolic syndrome, which is known to affect blood adipokine levels. This study examined blood adipokine levels in geriatric depression after adjusting for the effects of metabolic syndrome. Methods: Participants were selected from the Ansan Geriatric Study (depression group [n = 76] and control group [n = 76]). Blood concentrations of four adipokines (adiponectin, resistin, neutrophil-gelatinase-associated lipocalin [NGAL], and plasminogen activator inhibitor-1 [PAI-1]) were measured using immunoassays. The effects of blood adipokine concentration on the diagnosis of depression were analyzed using multivariate logistic regression to adjust for the effects of metabolic syndrome and potential confounding factors. Results: When the effects of metabolic syndrome and potential confounding factors were adjusted, only PAI-1 could explain the diagnosis of depression among all the adipokines. The depression group showed a lower blood PAI-1 level than the control group. Adiponectin, resistin, and NGAL could not explain the diagnosis of depression when the effects of metabolic syndrome and potential confounding factors were adjusted. Conclusion: This study suggests the possibility that the blood PAI-1 levels in clinically pathological late-life depression may show contrasting results to those with subclinical depressive symptoms. Additionally, considering that most previous studies have been conducted with pre-geriatric populations, the study suggests the possibility that geriatric depression may show inflammatory changes with patterns that are different from those of depression in the pre-geriatric population.
C1 [Lee, Seung-Hoon] Korea Univ, Dept Psychiat, Vet Hlth Serv Med Ctr, Coll Med, Seoul, South Korea.
   [Shin, Cheolmin; Ko, Young-Hoon; Lee, Moon -Soo; Han, Changsu] Korea Univ, Dept Psychiat, Coll Med, Seoul, South Korea.
   [Park, Moon Ho] Korea Univ, Dept Neurol, Coll Med, Seoul, South Korea.
   [Pae, Chi-Un] Catholic Univ Korea, Coll Med, Dept Psychiat, Seoul, South Korea.
   [Han, Changsu] Korea Univ, Coll Med, Dept Psychiat, Guro Hosp, 148 Gurodong Ro, Seoul 08308, South Korea.
C3 Veterans Health Service Medical Center; Korea University; Korea
   University Medicine (KU Medicine); Korea University; Korea University
   Medicine (KU Medicine); Korea University; Korea University Medicine (KU
   Medicine); Catholic University of Korea; Korea University; Korea
   University Medicine (KU Medicine)
RP Han, C (corresponding author), Korea Univ, Coll Med, Dept Psychiat, Guro Hosp, 148 Gurodong Ro, Seoul 08308, South Korea.
EM hancs@korea.ac.kr
RI Shin, Cheolmin/AAX-7092-2020; Pae, Chi-Un/AAG-5752-2020; Lee,
   Seung-Hoon/HPC-3773-2023; Han, Changsu/H-9926-2013; Lee,
   Moon-Soo/B-1203-2016
OI Lee, Seung-Hoon/0000-0001-5341-0933; Han, Changsu/0000-0002-4021-8907;
   Park, Moon Ho/0000-0002-4892-3475; Ko, Young-Hoon/0000-0002-5352-2158;
   Shin, Cheolmin/0000-0002-8232-2921; Lee, Moon-Soo/0000-0003-0729-6943
FU Ministry of Trade, Industry, and Energy (MOTIE) , Korea; Fostering
   Program for The Value-Chain through Industrial Intelligence [P0017821];
   Korea Institute for Advancement of Technology (KIAT)
FX This research was financially supported by the Ministry of Trade,
   Industry, and Energy (MOTIE) , Korea, under the Fostering Program for
   The Value-Chain through Industrial Intelligence (reference number
   P0017821) supervised by the Korea Institute for Advancement of
   Technology (KIAT) .
CR Abella V, 2015, BIOMARKERS, V20, P565, DOI 10.3109/1354750X.2015.1123354
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alexopoulos GS, 2011, INT J GERIATR PSYCH, V26, P1109, DOI 10.1002/gps.2672
   Alexopoulos GS, 1997, AM J PSYCHIAT, V154, P562
   [Anonymous], 2001, Journal of the Korean Neurological Association
   [Anonymous], 2006, Anxiety and Mood
   Bac JN, 2004, J PSYCHOSOM RES, V57, P297, DOI 10.1016/j.jpsychores.2004.01.004
   Baune BT, 2012, PSYCHONEUROENDOCRINO, V37, P1521, DOI 10.1016/j.psyneuen.2012.02.006
   Binder BR, 2002, NEWS PHYSIOL SCI, V17, P56, DOI 10.1152/nips.01369.2001
   Bruunsgaard H, 2001, CURR OPIN HEMATOL, V8, P131, DOI 10.1097/00062752-200105000-00001
   Chan MK, 2016, J PSYCHIATR RES, V83, P249, DOI 10.1016/j.jpsychires.2016.08.020
   COHEN J, 1992, PSYCHOL BULL, V112, P155, DOI 10.1037/0033-2909.112.1.155
   D'Mello C, 2009, J NEUROSCI, V29, P2089, DOI 10.1523/JNEUROSCI.3567-08.2009
   Dandona P, 2004, TRENDS IMMUNOL, V25, P4, DOI 10.1016/j.it.2003.10.013
   Degawa-Yamauchi M, 2003, J CLIN ENDOCR METAB, V88, P5452, DOI 10.1210/jc.2002-021808
   DiMusto PD, 2012, AM J PHYSIOL-HEART C, V302, pH1378, DOI 10.1152/ajpheart.00620.2011
   Diniz BS, 2012, J PSYCHIATR RES, V46, P1081, DOI 10.1016/j.jpsychires.2012.04.028
   Donahue RP, 2007, DIABETES CARE, V30, P354, DOI 10.2337/dc06-1772
   Eskandari F, 2005, METABOLISM, V54, P918, DOI 10.1016/j.metabol.2005.02.006
   FIGIEL GS, 1991, NEUROBIOL AGING, V12, P245, DOI 10.1016/0197-4580(91)90104-R
   Forti P, 2010, DEMENT GERIATR COGN, V29, P11, DOI 10.1159/000261644
   Ghadge AA, 2018, CYTOKINE GROWTH F R, V39, P151, DOI 10.1016/j.cytogfr.2018.01.004
   Gonzalez-Gay MA, 2008, CLIN EXP RHEUMATOL, V26, P596
   Grundy SM, 2016, TRENDS CARDIOVAS MED, V26, P364, DOI 10.1016/j.tcm.2015.10.004
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Han C, 2009, BMC NEUROL, V9, DOI 10.1186/1471-2377-9-10
   Hino H, 2001, NEUROSCI LETT, V297, P105, DOI 10.1016/S0304-3940(00)01679-7
   Huotari A, 2010, CARDIOVASC PSYCHIAT, V2010
   Irwin MR, 2007, BRAIN BEHAV IMMUN, V21, P374, DOI 10.1016/j.bbi.2007.01.010
   Jang Y, 2012, CLIN EXP PHARMACOL P, V39, P194, DOI 10.1111/j.1440-1681.2011.05557.x
   Je Cho， Maeng, 2009, [JOURNAL OF THE KOREAN NEUROPSYCHIATRIC ASSOCIATION, 신경정신의학], V48, P143
   Jiang HT, 2016, SCI REP-UK, V6, DOI 10.1038/srep30464
   Jung HY, 2007, ANN REHABIL MED-ARM, V31, P283
   Jung I.K., 1997, J KOREAN NEUROPSYCHI, P103
   Kadowaki T, 2005, ENDOCR REV, V26, P439, DOI 10.1210/er.2005-0005
   Kim E, 2010, ARCH GERONTOL GERIAT, V51, P231, DOI 10.1016/j.archger.2009.10.014
   KRISHNAN KRR, 1995, MED HYPOTHESES, V44, P111
   Lahlou-Laforet K, 2006, AM J CARDIOL, V97, P1287, DOI 10.1016/j.amjcard.2005.11.062
   Lasselin J, 2014, NEUROIMMUNOMODULAT, V21, P95, DOI 10.1159/000356535
   Lau DCW, 2005, AM J PHYSIOL-HEART C, V288, pH2031, DOI 10.1152/ajpheart.01058.2004
   Lee JH, 2002, J GERONTOL B-PSYCHOL, V57, pP47, DOI 10.1093/geronb/57.1.P47
   Lee SY, 2007, DIABETES RES CLIN PR, V75, P72, DOI 10.1016/j.diabres.2006.04.013
   Lindsay RS, 2002, LANCET, V360, P57, DOI 10.1016/S0140-6736(02)09335-2
   Lucin KM, 2009, NEURON, V64, P110, DOI 10.1016/j.neuron.2009.08.039
   Lundgren CH, 1996, CIRCULATION, V93, P106, DOI 10.1161/01.CIR.93.1.106
   Mansur RB, 2015, NEUROSCI BIOBEHAV R, V52, P89, DOI 10.1016/j.neubiorev.2014.12.017
   Matthews KA, 2007, PSYCHOSOM MED, V69, P124, DOI 10.1097/01.psy.0000256574.30389.1b
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   McKernan DP, 2009, PROG NEUROBIOL, V88, P246, DOI 10.1016/j.pneurobio.2009.04.006
   Melchor JP, 2005, THROMB HAEMOSTASIS, V93, P655, DOI 10.1160/TH04-12-0838
   MORRIS JC, 1993, NEUROLOGY, V43, P2412, DOI 10.1212/WNL.43.11.2412-a
   Mulvahill JS, 2017, J AM GERIATR SOC, V65, P2651, DOI 10.1111/jgs.15129
   Naudé PJW, 2013, J PSYCHOSOM RES, V75, P444, DOI 10.1016/j.jpsychores.2013.08.023
   Okamoto Y, 2006, CLIN SCI, V110, P267, DOI 10.1042/CS20050182
   Pan A, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001392
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Park JH, 2011, J KOREAN MED ASSOC, V54, P362, DOI 10.5124/jkma.2011.54.4.362
   Party H, 2019, ACTA NEUROPATHOL COM, V7, DOI 10.1186/s40478-019-0807-2
   Petersen RC, 1999, ARCH NEUROL-CHICAGO, V56, P303, DOI 10.1001/archneur.56.3.303
   Pyrzak B, 2010, EUR J MED RES, V15, P147
   Raison CL, 2006, TRENDS IMMUNOL, V27, P24, DOI 10.1016/j.it.2005.11.006
   RAO JS, 1993, J NEUROSCI RES, V34, P340, DOI 10.1002/jnr.490340311
   Ryo M, 2004, CIRC J, V68, P975, DOI 10.1253/circj.68.975
   Sheehan DV, 1998, J CLIN PSYCHIAT, V59, P22, DOI 10.4088/JCP.09m05305whi
   Soeda S, 2008, THROMB HAEMOSTASIS, V100, P1014, DOI 10.1160/TH08-04-0259
   Stefan N, 2002, DIABETES, V51, P1884, DOI 10.2337/diabetes.51.6.1884
   Supriya R, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0201585
   VANMOURIK JA, 1984, J BIOL CHEM, V259, P14914
   Weber-Hamann B, 2007, J PSYCHIATR RES, V41, P344, DOI 10.1016/j.jpsychires.2006.01.002
   Won CW., 2002, J Korean Geriatr Soc, V6, P107, DOI DOI 10.1037/T06803-000]
   Yatagai T, 2003, ENDOCR J, V50, P233, DOI 10.1507/endocrj.50.233
NR 71
TC 7
Z9 7
U1 1
U2 11
PU KOREAN COLL NEUROPSYCHOPHARMACOLOGY
PI SEOUL
PA RN 1003 OFFICETEL 40, 63-RO YEONGDEUNGPO-GU, SEOUL, 150-731, SOUTH KOREA
SN 1738-1088
EI 2093-4327
J9 CLIN PSYCHOPHARM NEU
JI Clin. Psychopharmacol. Neurosci.
PD FEB
PY 2023
VL 21
IS 1
BP 147
EP 161
DI 10.9758/cpn.2023.21.1.147
PG 15
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 8S2EE
UT WOS:000928396500011
PM 36700321
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wong, EML
   Leung, DYP
   Wang, Q
   Leung, AYM
   Cheung, ASP
AF Wong, Eliza Mi Ling
   Leung, Doris Yin Ping
   Wang, Qun
   Leung, Angela Yee Man
   Cheung, Alice Siu Ping
TI The effect of a lifestyle intervention program using a mobile
   application versus the effect of a program using a booklet for adults
   with metabolic syndrome: A three-arm randomized controlled trial
SO JOURNAL OF NURSING SCHOLARSHIP
LA English
DT Article
DE body weight; exercise; lifestyle intervention; m-health; metabolic
   syndrome
ID WEIGHT-LOSS; PHYSICAL-ACTIVITY; EXERCISE; TECHNOLOGY; IMPROVES; IMPACT
AB Purpose: The research aimed to examine the effect of a lifestyle intervention program using mobile application versus booklet for adults with metabolic syndrome in Hong Kong. The outcomes comprised body weight (primary outcome), exercise amount, improvement of cardiometabolic risk factors, cardiovascular endurance, perceived stress scale, and exercise self-efficacy.Design: A three-arm randomized controlled trial namely App group, Booklet group, and control group was adopted.Methods: Two hundred sixty-four adults with metabolic syndrome were recruited from community centers from 2019 to December 2021. Inclusion criteria are those adults with metabolic syndrome, able to use a smart phone. All participants received a 30-min health talk. App group additionally received a mobile application, while Booklet group received a booklet, and the control group received a placebo booklet. Data were collected at baseline, Weeks 4, 12, and 24. SPSS and generalized estimating equations (GEE) model were employed for data analysis.Findings: Attrition rates were minimal, ranged from 2.65% to 6.44%. Both app and booklet group showed significant improvement in outcomes (exercise amount, waist circumference) when compared to control group. However, statistically significant and superior results were observed in app group, including body weight, exercise amount, waist circumference, body mass index, and systolic blood pressure when compared to booklet group.Conclusion: The lifestyle intervention supported with app was found to be superior to the booklet support for reducing body weight and maintaining exercise.Clinical Relevance: The lifestyle intervention program using mobile application support could be used widely for adults with metabolic syndrome in the community. Suggest nurses may incorporate this program in their health promotion strategies focusing on a healthy lifestyle to reduce the risk of progression to metabolic syndrome.
C1 [Wong, Eliza Mi Ling] Tung Wah Coll, Sch Nursing, Hong Kong, Peoples R China.
   [Leung, Doris Yin Ping; Leung, Angela Yee Man; Cheung, Alice Siu Ping] Hong Kong Polytech Univ, Sch Nursing, Hong Kong, Peoples R China.
   [Wang, Qun] Shenzhen Univ, Sch Nursing, Shenzhen, Peoples R China.
C3 Tung Wah College; Hong Kong Polytechnic University; Shenzhen University
RP Leung, DYP (corresponding author), Hong Kong Polytech Univ, Sch Nursing, Hong Kong, Peoples R China.
EM doris.yp.leung@polyu.edu.hk
RI WANG, Qun/AAP-9908-2021; Leung, Angela/X-4415-2019; Wong,
   Eliza/AAH-6193-2020; Leung, Doris/T-6985-2019; Leung, Doris
   Y.P./K-4878-2014; Leung, Angela YM/C-4768-2009
OI Wong, Eliza ML/0000-0003-0698-9000; Leung, Doris
   Y.P./0000-0003-0138-8839; Leung, Angela YM/0000-0002-9836-1925
FU Health and Medical Research Fund, Food and Health Bureau, Hong Kong SAR
   [10110301]
FX Health and Medical Research Fund, Food and Health Bureau, Hong Kong SAR,
   Grant/Award Number: 10110301This research is supported by the Health and
   Medical Research Fund (No. 10110301), Food and Health Bureau, Hong Kong
   SAR
CR Al-Qawasmeh RH, 2018, CURR RES NUTR FOOD S, V6, P594, DOI 10.12944/CRNFSJ.6.3.03
   [Anonymous], 2017, eHealth
   Azar KMJ, 2016, J MED INTERNET RES, V18, DOI 10.2196/jmir.5143
   Bandura A., 1977, Self-efficacy: The exercise of control
   Bassi N, 2014, AM J MED, V127, DOI 10.1016/j.amjmed.2014.06.035
   Beaumont M, 2019, COPD, V16, P266, DOI 10.1080/15412555.2019.1656713
   Bohannon RW, 2015, J STRENGTH COND RES, V29, P3240, DOI 10.1519/JSC.0000000000000253
   Butnoriene J, 2015, INT J CARDIOL, V190, P360, DOI 10.1016/j.ijcard.2015.04.122
   Census and Statistical Department, 2015, HONG KONG INF SOC
   Centers of Disease and Prevention (CDC), 2018, BENEFITS PHYS ACTIVI
   Chang SH, 2019, CLIN NURS RES, V28, P658, DOI 10.1177/1054773817749923
   Cho SMJ, 2020, J MED INTERNET RES, V22, DOI 10.2196/17435
   Mateo GF, 2015, J MED INTERNET RES, V17, DOI 10.2196/jmir.4836
   Gheshlagh RG, 2016, IRAN RED CRESCENT ME, V18, DOI 10.5812/ircmj.26523
   Janz N.K., 2002, Health behavior and health education, V3rd, P45
   Godin G., 2011, HLTH FITNESS J CANAD, V4, P18, DOI [DOI 10.14288/HFJC.V4I1.82, 10.14288/hfjc.v4i1.82, 10.1037/t31334-000]
   Gomez-Huelgas R, 2015, EUR J INTERN MED, V26, P317, DOI 10.1016/j.ejim.2015.04.007
   Jahangiry L, 2017, NUTR DIABETES, V7, DOI 10.1038/nutd.2016.35
   Joseph MS, 2019, DIABET METAB SYND OB, V12, P2395, DOI 10.2147/DMSO.S211776
   Khaylis A, 2010, TELEMED J E-HEALTH, V16, P931, DOI 10.1089/tmj.2010.0065
   Lao XQ, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-983
   LaPlante C, 2011, TELEMED E-HEALTH, V17, P509, DOI 10.1089/tmj.2011.0013
   Leung DYP, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-513
   Lin CH, 2014, WORLDV EVID-BASED NU, V11, P361, DOI 10.1111/wvn.12069
   Luley C, 2014, J AM COLL NUTR, V33, P363, DOI 10.1080/07315724.2013.875437
   Mahadzir MDA, 2021, MEDICINA-LITHUANIA, V57, DOI 10.3390/medicina57111169
   Moher D, 2010, BMJ-BRIT MED J, V340, DOI [10.1016/j.jclinepi.2010.02.005, 10.1136/bmj.c869, 10.1186/1741-7015-8-18, 10.1016/j.ijsu.2011.10.001, 10.1136/bmj.c332, 10.4103/0976-500X.72352, 10.1186/1745-6215-11-32, 10.1016/j.jclinepi.2010.03.004]
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Mujica V, 2010, J AM SOC HYPERTENS, V4, P148, DOI 10.1016/j.jash.2010.02.008
   Munakata M, 2011, HYPERTENS RES, V34, P612, DOI 10.1038/hr.2010.272
   Nanri A, 2012, J OCCUP HEALTH, V54, P215, DOI 10.1539/joh.11-0238-OA
   Oh B, 2015, JMIR MHEALTH UHEALTH, V3, DOI 10.2196/mhealth.4222
   Ranasinghe P, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4041-1
   Saboya PP, 2017, ARQ BRAS CARDIOL, V108, P60, DOI 10.5935/abc.20160186
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Seligman BGS, 2011, METABOLISM, V60, P1736, DOI 10.1016/j.metabol.2011.05.006
   Spring B, 2013, JAMA INTERN MED, V173, P105, DOI 10.1001/jamainternmed.2013.1221
   Swift DL, 2018, PROG CARDIOVASC DIS, V61, P206, DOI 10.1016/j.pcad.2018.07.014
   The International Diabetes Federation (IDF), 2017, IDF CONS WORLDW DEF
   Vetter ML, 2011, INT J OBESITY, V35, P1087, DOI 10.1038/ijo.2010.230
   Wang Q, 2017, INT J CARDIOL, V230, P461, DOI 10.1016/j.ijcard.2016.12.084
   Whitehead L, 2016, J MED INTERNET RES, V18, DOI 10.2196/jmir.4883
   Wong EML, 2020, REHABIL NURS, V45, P74, DOI 10.1097/RNJ.0000000000000156
   Wong EML, 2021, CLIN INTERV AGING, V16, P633, DOI 10.2147/CIA.S303920
   Wong EML, 2020, WORLDV EVID-BASED NU, V17, P283, DOI 10.1111/wvn.12456
   World Health Organization, 2019, World Health Organization
   Wu YT, 2011, PREV MED, V52, P337, DOI 10.1016/j.ypmed.2011.02.018
NR 47
TC 11
Z9 11
U1 1
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1527-6546
EI 1547-5069
J9 J NURS SCHOLARSHIP
JI J. Nurs. Scholarsh.
PD SEP
PY 2023
VL 55
IS 5
BP 936
EP 948
DI 10.1111/jnu.12883
EA MAR 2023
PG 13
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA S0GV9
UT WOS:000959318900001
PM 36896916
DA 2025-06-11
ER

PT J
AU Hoerster, KD
   Campbell, S
   Dolan, M
   Stappenbeck, CA
   Yard, S
   Simpson, T
   Nelson, KM
AF Hoerster, Katherine D.
   Campbell, Sarah
   Dolan, Marketa
   Stappenbeck, Cynthia A.
   Yard, Samantha
   Simpson, Tracy
   Nelson, Karin M.
TI PTSD is associated with poor health behavior and greater Body Mass Index
   through depression, increasing cardiovascular disease and diabetes risk
   among US veterans
SO PREVENTIVE MEDICINE REPORTS
LA English
DT Article
DE PTSD; Depression; Cardiovascular disease; Diabetes; Health behavior
ID POSTTRAUMATIC-STRESS-DISORDER; PHYSICAL-ACTIVITY; MENTAL-HEALTH;
   METABOLIC SYNDROME; SERVICE MEMBERS; UNITED-STATES; SELF-REPORTS;
   WEIGHT-LOSS; EXERCISE; SYMPTOMS
AB Posttraumatic stress disorder (PTSD) is a risk factor for cardiovascular disease (CVD) and diabetes. Dedert and colleagues hypothesized a model whereby PTSD leads to poor health behaviors, depression, and pre-clinical disease markers, and that these factors lead to CVD and diabetes (Ann Behav Med, 2010, 61-78). This study provides a preliminary test of that model. Using data from a mailed cross-sectional survey conducted 2012-2013, path analysis was conducted among N = 657 with complete demographic data. We first analyzed the hypothesized model, followed by four alternatives, to identify the best-fitting model. The alternate model that specified pathways from depression to health behaviors had the best fit. Contrary to hypotheses, higher PTSD symptoms were associated with better physical activity and diet quality. Of the specific indirect pathways from PTSD to Body Mass Index (BMI), only the path through depression was significant. Higher depression symptoms were significantly associated with less physical activity, poorer diet, and greater likelihood of smoking. In addition, the specific indirect effect from depression to BMI through physical activity was significant. Current smoking and higher BMI were associated with greater likelihood of diabetes, and hypertension was associated with greater likelihood of CVD. PTSD symptoms may increase risk for CVD and diabetes through the negative impact of depression on health behaviors and BMI. With or without PTSD, depression may be an important target in interventions targeting cardiovascular and metabolic diseases among veterans.
C1 [Hoerster, Katherine D.; Campbell, Sarah; Nelson, Karin M.] VA Puget Sound Healthcare Syst, Seattle Div, Hlth Serv Res & Dev Serv, 1660 South Columbian Way,S-152, Seattle, WA 98108 USA.
   [Hoerster, Katherine D.; Campbell, Sarah; Dolan, Marketa; Yard, Samantha; Simpson, Tracy] VA Puget Sound Healthcare Syst, Seattle Div, Mental Hlth Serv, 1660 South Columbian Way,S-116, Seattle, WA 98108 USA.
   [Hoerster, Katherine D.; Campbell, Sarah; Stappenbeck, Cynthia A.; Simpson, Tracy] Univ Washington, Dept Psychiat & Behav Sci, 1100 NE 45th St,Suite 300, Seattle, WA 98105 USA.
   [Simpson, Tracy] VA Puget Sound Hlth Care, Ctr Excellence Subst Addict Treatment & Educ, 1660 S Columbian Way, Seattle, WA 98108 USA.
   [Nelson, Karin M.] VA Puget Sound Healthcare Syst, Gen Internal Med Serv, 1660 South Columbian Way, Seattle, WA 98108 USA.
   [Nelson, Karin M.] Univ Washington, Dept Med, 1959 NE Pacific St, Seattle, WA 98195 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Vet Affairs Puget Sound Health Care System; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); Vet Affairs Puget Sound
   Health Care System; University of Washington; University of Washington
   Seattle; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Vet Affairs Puget Sound Health Care System; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Vet Affairs Puget Sound Health Care System; University of Washington;
   University of Washington Seattle
RP Hoerster, KD (corresponding author), 1660 South Columbian Way,S-152, Seattle, WA 98108 USA.
EM Katherine.Hoerster@va.gov; Sarah.Campbell6@va.gov; Marketa.Dolan@va.gov;
   cstappen@uw.edu; Samantha.Yard@va.gov; Tracy.Simpson@va.gov;
   Karin.Nelson@va.gov
RI Campbell, Sarah/ITT-4766-2023
FU VA Puget Sound Healthcare System (VAPS); VAPS Mental Illness Research,
   Education, and Clinical Center; VAPS Health Services Research and
   Development (HSR&D) Center of Excellence; VA HSR&D Career Development
   Award [2015-2020] [CDA 12-263]; HSR&D OAA fellowship [TPH 61-000-23]
FX This work was supported by resources from VA Puget Sound Healthcare
   System (VAPS), and local funds from VAPS Mental Illness Research,
   Education, and Clinical Center and VAPS Health Services Research and
   Development (HSR&D) Center of Excellence. The first author is supported
   by a VA HSR&D Career Development Award [CDA 12-263; 2015-2020]. The
   second author is supported by an HSR&D OAA fellowship [TPH 61-000-23].
   Sponsors did not play any role in the study design; collection, analysis
   and interpretation of data; the writing of the report; or decision to
   submit the article for publication.
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Altman DG, 2006, BRIT MED J, V332, P1080, DOI 10.1136/bmj.332.7549.1080
   American Heart Association, 2017, SMOK HIGH BLOOD PRES
   [Anonymous], 1996, MEASUREMENT STRESS T
   [Anonymous], 2013, JCvD
   Barbour KA, 2007, J CARDIOPULM REHABIL, V27, P359, DOI 10.1097/01.HCR.0000300262.69645.95
   Baron KG, 2013, J CLIN SLEEP MED, V9, P819, DOI 10.5664/jcsm.2930
   Bergman HE, 2017, MIL PSYCHOL, V29, P117, DOI 10.1037/mil0000154
   Bonnet F, 2005, ATHEROSCLEROSIS, V178, P339, DOI 10.1016/j.atherosclerosis.2004.08.035
   Boscarino JA, 2012, PREV MED, V54, P363, DOI 10.1016/j.ypmed.2012.01.001
   Boutcher SH, 2009, OBES REV, V10, P671, DOI 10.1111/j.1467-789X.2009.00621.x
   Boyko EJ, 2013, DIABETES CARE, V36, P3154, DOI 10.2337/DC13-0042
   Brug J, 2008, FAM PRACT, V25, pI50, DOI 10.1093/fampra/cmn063
   Buckley TC, 2004, MIL MED, V169, P536, DOI 10.7205/MILMED.169.7.536
   Bush K, 1998, ARCH INTERN MED, V158, P1789, DOI 10.1001/archinte.158.16.1789
   Campbell SB, 2017, BEHAV THER, V48, P448, DOI 10.1016/j.beth.2017.01.003
   Campbell SB, 2017, BEHAV THER, V48, P222, DOI 10.1016/j.beth.2016.04.006
   Charuvastra A, 2008, ANNU REV PSYCHOL, V59, P301, DOI 10.1146/annurev.psych.58.110405.085650
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   Cronce JM, 2017, OBESITY, V25, P801, DOI 10.1002/oby.21809
   Danaei G, 2009, PLOS MED, V6, DOI 10.1371/journal.pmed.1000058
   Dare S, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0123579
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   Debell F, 2014, SOC PSYCH PSYCH EPID, V49, P1401, DOI 10.1007/s00127-014-0855-7
   Dedert EA, 2010, ANN BEHAV MED, V39, P61, DOI 10.1007/s12160-010-9165-9
   Dohrenwend BP, 2006, SCIENCE, V313, P979, DOI 10.1126/science.1128944
   Fan VS, 2002, J CLIN EPIDEMIOL, V55, P371, DOI 10.1016/S0895-4356(01)00493-0
   Fu SS, 2007, NICOTINE TOB RES, V9, P1071, DOI 10.1080/14622200701488418
   Go AS, 2013, CIRCULATION, V127, P143, DOI [10.1161/CIR.0b013e318282ab8f, 10.1161/CIR.0000000000000366]
   Goldstein LA, 2018, J AFFECT DISORDERS, V227, P345, DOI 10.1016/j.jad.2017.11.002
   Grant BF, 2004, ARCH GEN PSYCHIAT, V61, P807, DOI 10.1001/archpsyc.61.8.807
   Hall KS, 2015, EPIDEMIOL REV, V37, P103, DOI 10.1093/epirev/mxu011
   Harte CB, 2015, EVAL HEALTH PROF, V38, P42, DOI 10.1177/0163278713494774
   Hayes AF, 2017, BEHAV RES THER, V98, P39, DOI 10.1016/j.brat.2016.11.001
   Hoerster KD, 2015, SOC SCI MED, V142, P100, DOI 10.1016/j.socscimed.2015.07.034
   Hoerster KD, 2014, PSYCHIAT SERV, V65, P1385, DOI 10.1176/appi.ps.201300404
   Hoerster KD, 2012, AM J PREV MED, V43, P483, DOI 10.1016/j.amepre.2012.07.029
   HOERSTER KD, 2014, ANN BEHAV MED S1, V47, pS14
   Hoge CW, 2004, NEW ENGL J MED, V351, P13, DOI 10.1056/NEJMoa040603
   Johannessen KB, 2013, J CLIN PSYCHOL, V69, P655, DOI 10.1002/jclp.21962
   Kline R.B., 2015, Principles and Practice of Structural Equation Modeling, DOI [10.15353/cgjsc.v1i1.3787, DOI 10.15353/CGJSC.V1I1.3787]
   Kriegsman DMW, 1996, J CLIN EPIDEMIOL, V49, P1407, DOI 10.1016/S0895-4356(96)00274-0
   Kroenke K, 2009, J AFFECT DISORDERS, V114, P163, DOI 10.1016/j.jad.2008.06.026
   Lasser K, 2000, JAMA-J AM MED ASSOC, V284, P2606, DOI 10.1001/jama.284.20.2606
   LeardMann CA, 2015, OBESITY, V23, P886, DOI 10.1002/oby.21025
   LeardMann CA, 2011, PUBLIC HEALTH REP, V126, P371, DOI 10.1177/003335491112600311
   Lehavot K, 2012, AM J PREV MED, V42, P473, DOI 10.1016/j.amepre.2012.01.006
   Marazziti D, 2014, CNS SPECTRUMS, V19, P293, DOI 10.1017/S1092852913000667
   McFall M, 2010, JAMA-J AM MED ASSOC, V304, P2485, DOI 10.1001/jama.2010.1769
   Mitchell KS, 2016, AM J EPIDEMIOL, V184, P33, DOI 10.1093/aje/kwv291
   Paxton AE, 2011, AM J PREV MED, V40, P67, DOI 10.1016/j.amepre.2010.10.009
   Pietrzak RH, 2011, J ANXIETY DISORD, V25, P456, DOI 10.1016/j.janxdis.2010.11.010
   Rutter LA, 2013, PSYCHOL TRAUMA-US, V5, P56, DOI 10.1037/a0021996
   Seal KH, 2007, ARCH INTERN MED, V167, P476, DOI 10.1001/archinte.167.5.476
   Shaikh AR, 2008, AM J PREV MED, V34, P535, DOI 10.1016/j.amepre.2007.12.028
   Sherwood NE, 2000, ANNU REV NUTR, V20, P21, DOI 10.1146/annurev.nutr.20.1.21
   Shipherd JC, 2014, J BEHAV MED, V37, P423, DOI 10.1007/s10865-013-9500-2
   Smith I, 2011, AUST ARCHAEOL, P58
   St-Onge MP, 2013, J CLIN SLEEP MED, V9, P73, DOI 10.5664/jcsm.2348
   Ströhle A, 2009, J NEURAL TRANSM, V116, P777, DOI 10.1007/s00702-008-0092-x
   Theal R, 2018, NUTR RES, V54, P12, DOI 10.1016/j.nutres.2018.03.002
   Tisnado DM, 2006, MED CARE, V44, P132, DOI 10.1097/01.mlr.0000196952.15921.bf
   van den Berk-Clark C, 2018, HEALTH PSYCHOL, V37, P407, DOI 10.1037/hea0000593
   Vasterling JJ, 2008, J REHABIL RES DEV, V45, P347, DOI 10.1682/JRRD.2007.05.0077
   Vasterling JJ, 2006, JAMA-J AM MED ASSOC, V296, P519, DOI 10.1001/jama.296.5.519
NR 65
TC 39
Z9 48
U1 1
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2211-3355
J9 PREV MED REP
JI Prev. Med. Rep.
PD SEP
PY 2019
VL 15
AR 100930
DI 10.1016/j.pmedr.2019.100930
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA VJ9EF
UT WOS:000645518700047
PM 31338278
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Scheewe, TW
   Backx, FJG
   Takken, T
   Jörg, F
   van Strater, ACP
   Kroes, AG
   Kahn, RS
   Cahn, W
AF Scheewe, T. W.
   Backx, F. J. G.
   Takken, T.
   Jorg, F.
   van Strater, A. C. P.
   Kroes, A. G.
   Kahn, R. S.
   Cahn, W.
TI Exercise therapy improves mental and physical health in schizophrenia: a
   randomised controlled trial
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE mental health; physical health; need of care; cardiovascular fitness;
   metabolic syndrome
ID NEGATIVE-SYNDROME-SCALE; MOTIVATIONAL INTERVENTION; SYMPTOMS; PEOPLE;
   RISK; RELIABILITY; INSTRUMENT; MANAGEMENT; OLANZAPINE; STATEMENT
AB Objective The objective of this multicenter randomised clinical trial was to examine the effect of exercise versus occupational therapy on mental and physical health in schizophrenia patients. Method Sixty-three patients with schizophrenia were randomly assigned to 2h of structured exercise (n=31) or occupational therapy (n=32) weekly for 6months. Symptoms (Positive and Negative Syndrome Scale) and cardiovascular fitness levels (Wpeak and VO2peak), as assessed with a cardiopulmonary exercise test, were the primary outcome measures. Secondary outcome measures were the Montgomery and angstrom sberg Depression Rating Scale, Camberwell Assessment of Needs, body mass index, body fat percentage, and metabolic syndrome (MetS). Results Intention-to-treat analyses showed exercise therapy had a trend-level effect on depressive symptoms (P=0.07) and a significant effect on cardiovascular fitness, measured by Wpeak (P<0.01), compared with occupational therapy. Per protocol analyses showed that exercise therapy reduced symptoms of schizophrenia (P=0.001), depression (P=0.012), need of care (P=0.050), and increased cardiovascular fitness (P<0.001) compared with occupational therapy. No effect for MetS (factors) was found except a trend reduction in triglycerides (P=0.08). Conclusion Exercise therapy, when performed once to twice a week, improved mental health and cardiovascular fitness and reduced need of care in patients with schizophrenia.
C1 [Scheewe, T. W.; Kroes, A. G.; Kahn, R. S.; Cahn, W.] Univ Med Ctr Utrecht, Dept Psychiat, Rudolf Magnus Inst Neurosci, NL-3584 CX Utrecht, Netherlands.
   [Backx, F. J. G.] Univ Med Ctr Utrecht, Dept Rehabil Nursing Sci & Sports, Rudolf Magnus Inst Neurosci, NL-3584 CX Utrecht, Netherlands.
   [Takken, T.] Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Child Dev & Exercise Ctr, NL-3584 CX Utrecht, Netherlands.
   [Jorg, F.] GGZ Friesland, Leeuwarden, Netherlands.
   [van Strater, A. C. P.] GGZ Duin En Bollenstreek, Voorhout, Netherlands.
   [Kroes, A. G.] Julius Clin Res, Zeist, Netherlands.
C3 Utrecht University; Utrecht University Medical Center; Utrecht
   University; Utrecht University Medical Center; Wilhelmina
   Kinderziekenhuis; Utrecht University; Utrecht University Medical Center
RP Scheewe, TW (corresponding author), Univ Med Ctr Utrecht, Dept Psychiat, A00-241,Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands.
EM tscheewe@umcutrecht.nl
RI Takken, Tim/A-9912-2010; Cahn, W/B-5743-2013
OI Takken, Tim/0000-0002-7737-118X
FU Eli Lilly; BMS; Lundbeck; Sanofi-Aventis; Janssen-Cilag; Astra-Zeneca;
   Schering-Plough
FX Dr. W. Cahn is or has been an unrestricted research grant holder with,
   or has received financial compensation as an independent symposium
   speaker, or as an consultant from, Eli Lilly, BMS, Lundbeck,
   Sanofi-Aventis, Janssen-Cilag, Astra-Zeneca and Schering-Plough. All
   other authors have declared that there are no conflicts of interest in
   relation to the subject of this study.
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   ANDREASEN NC, 1992, ARCH GEN PSYCHIAT, V49, P615
   Astorino TA, 2009, CLIN PHYSIOL FUNCT I, V29, P60, DOI 10.1111/j.1475-097X.2008.00835.x
   Beebe Lora Humphrey, 2005, Issues Ment Health Nurs, V26, P661
   Beebe LH, 2012, SCHIZOPHR RES, V135, P204, DOI 10.1016/j.schres.2011.12.008
   Beebe LH, 2011, COMMUNITY MENT HLT J, V47, P628, DOI 10.1007/s10597-010-9363-8
   Bille K, 2006, EUR J CARDIOV PREV R, V13, P859, DOI 10.1097/01.hjr.0000238397.50341.4a
   Christensen BK, 2007, PSYCHOL ASSESSMENT, V19, P236, DOI 10.1037/1040-3590.19.2.236
   Cohen J., 1988, STAT POWER ANAL BEHA, V2, P1
   Commissie Farmaceutische Hulp, 2002, FARM KOMP
   Dishman RK, 1997, MED SCI SPORT EXER, V29, P63, DOI 10.1097/00005768-199701000-00010
   Duraiswamy G, 2007, ACTA PSYCHIAT SCAND, V116, P226, DOI 10.1111/j.1600-0447.2007.01032.x
   DURNIN JVGA, 1974, BRIT J NUTR, V32, P77, DOI 10.1079/BJN19740060
   Garber CE, 2011, MED SCI SPORT EXER, V43, P1334, DOI 10.1249/MSS.0b013e318213fefb
   Godfrey S., 1974, Exercise Testing in Children: Applications in Health and Disease
   Gorczynski P, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004412.pub2
   Gravel J, 2007, CLIN TRIALS, V4, P350, DOI 10.1177/1740774507081223
   Hausmann A, 2002, ACTA PSYCHIAT SCAND, V106, P83, DOI 10.1034/j.1600-0447.2002.02120.x
   Heggelund J, 2011, BMC PSYCHIATRY, V11, DOI 10.1186/1471-244X-11-188
   Heggelund J, 2011, NORD J PSYCHIAT, V65, P269, DOI 10.3109/08039488.2011.560278
   Hokanson J E, 1996, J Cardiovasc Risk, V3, P213, DOI 10.1097/00043798-199604000-00014
   Jamieson JL, 2003, EXERCISE PSYCHOL, P218
   KAY SR, 1988, PSYCHIAT RES, V23, P99, DOI 10.1016/0165-1781(88)90038-8
   Kraemer WJ, 2002, MED SCI SPORT EXER, V34, P364, DOI 10.1097/00005768-200202000-00027
   Kwon JS, 2006, J CLIN PSYCHIAT, V67, P547, DOI 10.4088/JCP.v67n0405
   Lindamer LA, 2008, SCHIZOPHR RES, V104, P294, DOI 10.1016/j.schres.2008.04.040
   Lodge P, 2006, PHYS ACTIVITY TREATM
   Marzolini S., 2009, MENT HEALTH PHYS ACT, V2, P29, DOI 10.1016/j.mhpa.2008.11.001
   McCreadie RG, 2003, BRIT J PSYCHIAT, V183, P534, DOI 10.1192/bjp.183.6.534
   McGrath J, 2008, EPIDEMIOL REV, V30, P67, DOI 10.1093/epirev/mxn001
   Meyer JM, 2008, SCHIZOPHR RES, V103, P104, DOI 10.1016/j.schres.2008.04.023
   MONTGOMERY SA, 1979, BRIT J PSYCHIAT, V134, P382, DOI 10.1192/bjp.134.4.382
   Mueser KT, 2004, LANCET, V363, P2063, DOI 10.1016/S0140-6736(04)16458-1
   Newcomer JW, 2009, J CLIN PSYCHIAT, V70, P487, DOI 10.4088/JCP.08m04132
   Pajonk FG, 2010, ARCH GEN PSYCHIAT, V67, P133, DOI 10.1001/archgenpsychiatry.2009.193
   Pelham T., 1993, PSYCHOSOC REHABIL J, V16, P75
   PHELAN M, 1995, BRIT J PSYCHIAT, V167, P589, DOI 10.1192/bjp.167.5.589
   Pollock ML, 1998, MED SCI SPORT EXER, V30, P975, DOI 10.1097/00005768-199806000-00032
   Röhricht F, 2006, PSYCHOL MED, V36, P669, DOI 10.1017/S0033291706007161
   Saha S, 2007, ARCH GEN PSYCHIAT, V64, P1123, DOI 10.1001/archpsyc.64.10.1123
   Stahl SM, 2007, ACTA PSYCHIAT SCAND, V115, P4, DOI 10.1111/j.1600-0447.2006.00947.x
   Strassnig M, 2011, SCHIZOPHR RES, V126, P103, DOI 10.1016/j.schres.2010.10.025
   Thorogood A, 2011, AM J MED, V124, P747, DOI 10.1016/j.amjmed.2011.02.037
   Tkachuk GA, 1999, PROF PSYCHOL-RES PR, V30, P275, DOI 10.1037/0735-7028.30.3.275
   van der Gaag M, 2006, SCHIZOPHR RES, V85, P280, DOI 10.1016/j.schres.2006.03.021
   Vancampfort D, 2012, ACTA PSYCHIAT SCAND, V126, P12, DOI 10.1111/j.1600-0447.2012.01865.x
   Vancampfort D, 2012, ACTA PSYCHIAT SCAND, V125, P352, DOI 10.1111/j.1600-0447.2011.01814.x
   Vancampfort D, 2012, ACTA PSYCHIAT SCAND, V125, P382, DOI 10.1111/j.1600-0447.2011.01825.x
   Vancampfort D, 2011, ACTA PSYCHIAT SCAND, V123, P423, DOI 10.1111/j.1600-0447.2010.01666.x
   Vancampfort D, 2011, ACTA PSYCHIAT SCAND, V125, P362
   Vancampfort D, 2012, DISABIL REHABIL, V34, P1, DOI 10.3109/09638288.2011.587090
   Vancampfort D, 2010, PSYCHIAT RES, V177, P271, DOI 10.1016/j.psychres.2010.03.011
   Verge B, 2011, EUR PSYCHIAT, V26, P45, DOI 10.1016/j.eurpsy.2010.08.008
   Verhage F, 1983, THESIS U HOSP GRONIN
   von Hausswolff-Juhlin Y, 2009, ACTA PSYCHIAT SCAND, V119, P15, DOI 10.1111/j.1600-0447.2008.01309.x
   Wildgust HJ, 2010, J PSYCHOPHARMACOL, V24, P37, DOI 10.1177/1359786810384639
NR 56
TC 172
Z9 194
U1 1
U2 78
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
EI 1600-0447
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD JUN
PY 2013
VL 127
IS 6
BP 464
EP 473
DI 10.1111/acps.12029
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 141AO
UT WOS:000318697900009
PM 23106093
DA 2025-06-11
ER

PT J
AU Lockhart, G
   MacKinnon, DP
   Ohlrich, V
AF Lockhart, Ginger
   MacKinnon, David P.
   Ohlrich, Vanessa
TI Mediation Analysis in Psychosomatic Medicine Research
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE statistical mediation; mediation analysis; mechanism; indirect effect
ID BEHAVIORAL STRESS-MANAGEMENT; ARTERY RISK DEVELOPMENT;
   SOCIOECONOMIC-STATUS; SOCIAL SUPPORT; BLOOD-PRESSURE; YOUNG-ADULTS;
   EDUCATIONAL-ATTAINMENT; PSYCHOLOGICAL STRESS; METABOLIC SYNDROME;
   LONGITUDINAL DATA
AB This article presents an overview of statistical mediation analysis and its application to psychosomatic medicine research. The article begins with a description of the major approaches to mediation analysis and an evaluation of the strengths and limits of each. Emphasis is placed on longitudinal mediation models, and an application using latent growth modeling is presented. The article concludes with a description of recent developments in mediation analysis and suggestions for the use of mediation for future work in psychosomatic medicine research.
C1 [Lockhart, Ginger] Arizona State Univ, Dept Psychol, Res Prevent Lab, Tempe, AZ 85287 USA.
C3 Arizona State University; Arizona State University-Tempe
RP Lockhart, G (corresponding author), Arizona State Univ, Dept Psychol, Res Prevent Lab, POB 871104, Tempe, AZ 85287 USA.
EM ginger.lockhart@asu.edu
RI MacKinnon, David/D-8727-2013
OI MacKinnon, David/0000-0003-0866-6010
FU National Institute of Drug Abuse [R01DA009757-09]; National Institute of
   Mental Health [P30 MH066247]
FX This work was supported by the National Institute of Drug Abuse
   (R01DA009757-09; MacKinnon) and the National Institute of Mental Health
   (P30 MH066247; Lockhart).
CR Agresti A., 2002, Categorical data analysis., V2, DOI 10.1002/0471249688
   ALWIN DF, 1975, AM SOCIOL REV, V40, P37, DOI 10.2307/2094445
   [Anonymous], 1991, BEST METHODS ANAL CH
   [Anonymous], METHODOLOGICAL ISSUE
   [Anonymous], LISREL VERSION 8 5 C
   [Anonymous], 2004, SAGE HDB QUANTITATIV, DOI DOI 10.4135/9781412986311
   [Anonymous], 2009, Causality
   [Anonymous], STAT STRATEGIES SMAL
   BANDURA A, 1989, AM PSYCHOL, V44, P1175, DOI 10.1037/0003-066X.44.9.1175
   BARON RM, 1986, J PERS SOC PSYCHOL, V51, P1173, DOI 10.1037/0022-3514.51.6.1173
   Bauer DJ, 2003, PSYCHOL METHODS, V8, P338, DOI 10.1037/1082-989X.8.3.338
   Bollen KA., 1990, SOCIOL METHODOL, V20, P115, DOI DOI 10.2307/271084
   Bosch JA, 2005, PSYCHOSOM MED, V67, P366, DOI 10.1097/01.psy.0000160469.00312.8e
   Brummett BH, 2005, PSYCHOSOM MED, V67, P40, DOI 10.1097/01.psy.0000149257.74854.b7
   Carney RM, 2007, PSYCHOSOM MED, V69, P4, DOI 10.1097/01.psy.0000249733.33811.00
   Chen E, 2003, PSYCHOSOM MED, V65, P984, DOI 10.1097/01.PSY.0000097340.54195.3C
   Cheong J, 2003, STRUCT EQU MODELING, V10, P238, DOI 10.1207/S15328007SEM1002_5
   Chesney MA, 2003, PSYCHOSOM MED, V65, P1038, DOI 10.1097/01.PSY.0000097344.78697.ED
   Christensen U, 2004, PSYCHOSOM MED, V66, P572, DOI 10.1097/01.psy.0000126206.35683.d1
   Ciechanowski P, 2004, PSYCHOSOM MED, V66, P720, DOI 10.1097/01.psy.0000138125.59122.23
   Cohen M, 2005, PSYCHOSOM MED, V67, P64, DOI 10.1097/01.psy.0000151746.36540.6e
   Cohen M, 2007, PSYCHOSOM MED, V69, P313, DOI 10.1097/PSY.0b013e318051542c
   Cohen S, 1999, PSYCHOSOM MED, V61, P175, DOI 10.1097/00006842-199903000-00009
   Cohen S, 2006, PSYCHOSOM MED, V68, P41, DOI 10.1097/01.psy.0000195967.51768.ea
   Cole DA, 2003, J ABNORM PSYCHOL, V112, P558, DOI 10.1037/0021-843X.112.4.558
   Collins LM, 1998, MULTIVAR BEHAV RES, V33, P295, DOI 10.1207/s15327906mbr3302_5
   Craig CC, 1936, ANN MATH STAT, V7, P1, DOI 10.1214/aoms/1177732541
   Creed F, 2005, PSYCHOSOM MED, V67, P490, DOI 10.1097/01.psy.0000163457.32382.ac
   Cruess DG, 2000, PSYCHOSOM MED, V62, P304, DOI 10.1097/00006842-200005000-00002
   Cruess S, 2000, PSYCHOSOM MED, V62, P828, DOI 10.1097/00006842-200011000-00013
   Devriese S, 2000, PSYCHOSOM MED, V62, P751, DOI 10.1097/00006842-200011000-00003
   Deykin EY, 2001, PSYCHOSOM MED, V63, P835, DOI 10.1097/00006842-200109000-00018
   Ditzen B, 2008, PSYCHOSOM MED, V70, P883, DOI 10.1097/PSY.0b013e318185c4fc
   DuHamel KN, 2004, PSYCHOSOM MED, V66, P92, DOI 10.1097/01.PSY.0000108104.23738.04
   Dwyer J.H., 1983, STAT MODELS SOCIAL B
   Emsley R, 2010, STAT METHODS MED RES, V19, P237, DOI 10.1177/0962280209105014
   Epel ES, 2000, PSYCHOSOM MED, V62, P623, DOI 10.1097/00006842-200009000-00005
   Fairchild AJ, 2009, PREV SCI, V10, P87, DOI 10.1007/s11121-008-0109-6
   Fairchild AJ, 2009, BEHAV RES METHODS, V41, P486, DOI 10.3758/BRM.41.2.486
   Favaro A, 2008, PSYCHOSOM MED, V70, P372, DOI 10.1097/PSY.0b013e318164604e
   Ferrer E, 2003, STRUCT EQU MODELING, V10, P493, DOI 10.1207/S15328007SEM1004_1
   Frangakis CE, 2002, BIOMETRICS, V58, P21, DOI 10.1111/j.0006-341X.2002.00021.x
   Frasure-Smith N, 2002, PSYCHOSOM MED, V64, P571, DOI 10.1097/01.PSY.0000021950.04969.F8
   Freedman LS, 2001, J STAT PLAN INFER, V96, P143, DOI 10.1016/S0378-3758(00)00330-X
   Friedberg F, 2007, PSYCHOSOM MED, V69, P54, DOI 10.1097/PSY.0b013e31802b873e
   Fritz MS, 2007, PSYCHOL SCI, V18, P233, DOI 10.1111/j.1467-9280.2007.01882.x
   Gale CR, 2008, PSYCHOSOM MED, V70, P397, DOI 10.1097/PSY.0b013e31816a719e
   Gallo LC, 2003, PSYCHOSOM MED, V65, P952, DOI 10.1097/01.PSY.0000097350.95305.FE
   Gallo LC, 2001, PSYCHOSOM MED, V63, P925, DOI 10.1097/00006842-200111000-00011
   Garcia-Linares MI, 2004, PSYCHOSOM MED, V66, P965, DOI 10.1097/01.psy.0000145820.90041.c0
   Germain A, 2003, PSYCHOSOM MED, V65, P857, DOI 10.1097/01.PSY.0000079376.87711.B0
   Glei DA, 2007, PSYCHOSOM MED, V69, P769, DOI 10.1097/PSY.0b013e318157cba6
   Gore-Felton C, 2008, PSYCHOSOM MED, V70, P569, DOI 10.1097/PSY.0b013e318177353e
   Greenland S, 2000, J AM STAT ASSOC, V95, P286, DOI 10.2307/2669548
   Grewen KM, 2004, PSYCHOSOM MED, V66, P9, DOI 10.1097/01.PSY.0000106881.60228.16
   Gump BB, 2001, PSYCHOSOM MED, V63, P423, DOI 10.1097/00006842-200105000-00011
   Hall M, 1998, PSYCHOSOM MED, V60, P48, DOI 10.1097/00006842-199801000-00011
   Holland P. W., 1988, Sociol. Methodol., V18, P449, DOI DOI 10.2307/271055
   Holmbeck GN, 1997, J CONSULT CLIN PSYCH, V65, P599, DOI 10.1037/0022-006X.65.4.599
   Hurwitz BE, 1998, PSYCHOSOM MED, V60, P102, DOI 10.1097/00006842-199801000-00059
   JAMES LR, 1984, J APPL PSYCHOL, V69, P307, DOI 10.1037/0021-9010.69.2.307
   Janicki-Deverts D, 2007, PSYCHOSOM MED, V69, P514, DOI 10.1097/PSY.0b013e3180f60645
   Johnston-Brooks CH, 2002, PSYCHOSOM MED, V64, P43, DOI 10.1097/00006842-200201000-00007
   Johnston-Brooks CH, 1998, PSYCHOSOM MED, V60, P597, DOI 10.1097/00006842-199809000-00015
   Judd C. M., 1981, Estimating the Effects of Social Intervention
   JUDD CM, 1981, EVALUATION REV, V5, P602, DOI 10.1177/0193841X8100500502
   Kenny D. A., 1998, HDB SOCIAL PSYCHOL, V1
   Keogh E, 2006, PSYCHOSOM MED, V68, P167, DOI 10.1097/01.psy.0000197742.50988.9e
   Kivimaki M, 2002, PSYCHOSOM MED, V64, P817, DOI 10.1097/01.PSY.0000031576.42041.B1
   Kivimäki M, 2008, PSYCHOSOM MED, V70, P1, DOI 10.1097/PSY.0b013e318l5aaca3
   Kraemer HC, 2001, AM J PSYCHIAT, V158, P848, DOI 10.1176/appi.ajp.158.987.848
   Kullowatz A, 2008, PSYCHOSOM MED, V70, P468, DOI 10.1097/PSY.0b013e31816f9c2f
   Labus JS, 2007, PSYCHOSOM MED, V69, P89, DOI 10.1097/PSY.0b013e31802e2f24
   Lackner JM, 2004, PSYCHOSOM MED, V66, P435, DOI 10.1097/01.psy.0000126195.82317.46
   Last J.M., 1988, DICT EPIDEMIOLOGY, V2nd
   Levenstein S, 2000, PSYCHOSOM MED, V62, P176, DOI 10.1097/00006842-200003000-00003
   Llabre MM, 2004, PSYCHOSOM MED, V66, P29, DOI 10.1097/01.PSY.0000107886.51781.9C
   Lo YT, 2001, BIOMETRIKA, V88, P767, DOI 10.1093/biomet/88.3.767
   Luecken LJ, 2005, PSYCHOSOM MED, V67, P514, DOI 10.1097/01.psy.0000160466.10397.18
   Lustman PJ, 2005, PSYCHOSOM MED, V67, P195, DOI 10.1097/01.psy.0000155670.88919.ad
   MacKinnon D., 2012, INTRO STAT MEDIATION
   MacKinnon D P, 2000, Prev Sci, V1, P173, DOI 10.1023/A:1026595011371
   MacKinnon DavidP., 2000, Multivariate Applications in Substance Use Research: New Methods for New Questions
   MACKINNON DP, 1993, EVALUATION REV, V17, P144, DOI 10.1177/0193841X9301700202
   MacKinnon DP, 2004, MULTIVAR BEHAV RES, V39, P99, DOI 10.1207/s15327906mbr3901_4
   MACKINNON DP, 1995, MULTIVAR BEHAV RES, V30, pR2
   MacKinnon DP, 2002, PSYCHOL METHODS, V7, P83, DOI 10.1037/1082-989X.7.1.83
   Mancuso RA, 2004, PSYCHOSOM MED, V66, P762, DOI 10.1097/01.psy.0000138284.70670.d5
   Manne S, 2001, PSYCHOSOM MED, V63, P658, DOI 10.1097/00006842-200107000-00019
   MARK MM, 1986, ADV QUASIEXPERIMENTA
   Matthews KA, 2000, PSYCHOSOM MED, V62, P231, DOI 10.1097/00006842-200003000-00015
   Maxwell SE, 2007, PSYCHOL METHODS, V12, P23, DOI 10.1037/1082-989X.12.1.23
   McArdle J.J., 2003, Comprehensive handbook of psychology, Volume II, VII
   McCutcheon AL., 1987, LATENT CLASS ANAL SA
   McDonald RP, 1997, MULTIVAR BEHAV RES, V32, P1, DOI 10.1207/s15327906mbr3201_1
   Meeker W.Q., 1981, SELECTED TABLES MATH, VVII
   MERRILL RM, 1994, THESIS ARIZONA STATE
   Miller GE, 2004, PSYCHOSOM MED, V66, P215, DOI 10.1097/01.psy.0000116718.54414.9e
   Miller GE, 1999, PSYCHOSOM MED, V61, P850, DOI 10.1097/00006842-199911000-00021
   Miller G, 2007, PSYCHOSOM MED, V69, P402, DOI 10.1097/PSY.0b013e318068fcf9
   Mohr D, 2003, PSYCHOSOM MED, V65, P485, DOI 10.1097/01.PSY.0000041404.96597.38
   Moore PJ, 2002, PSYCHOSOM MED, V64, P337, DOI 10.1097/00006842-200203000-00018
   Morin CM, 2003, PSYCHOSOM MED, V65, P259, DOI 10.1097/01.PSY.0000030391.09558.A3
   Murali R, 2005, ANN BEHAV MED, V30, P155, DOI 10.1207/s15324796abm3002_8
   Muthen B.O., 2006, Advances in longitudinal data analysis
   MUTHEN LK, 1998, MPLUS 3 0 USERS GUID
   Mykletun A, 2007, PSYCHOSOM MED, V69, P323, DOI 10.1097/PSY.0b013e31803cb862
   Niaura R, 2000, PSYCHOSOM MED, V62, P7, DOI 10.1097/00006842-200001000-00002
   Nylund KL, 2007, STRUCT EQU MODELING, V14, P535, DOI 10.1080/10705510701575396
   Peters ML, 1999, PSYCHOSOM MED, V61, P513, DOI 10.1097/00006842-199907000-00016
   Räikkönen K, 2004, PSYCHOSOM MED, V66, P903, DOI 10.1097/01.psy.0000143638.31297.11
   Ranby KW, 2009, J PEDIATR PSYCHOL, V34, P1069, DOI 10.1093/jpepsy/jsp025
   ROBINS JM, 1992, EPIDEMIOLOGY, V3, P143, DOI 10.1097/00001648-199203000-00013
   Rodriguez D, 2007, PSYCHOSOM MED, V69, P106, DOI 10.1097/PSY.0b013e31802e0f0e
   Rojo L, 2006, PSYCHOSOM MED, V68, P628, DOI 10.1097/01.psy.0000227749.58726.41
   RUESCH J, 1961, PSYCHOSOM MED, V23, P277, DOI 10.1097/00006842-196107000-00001
   SCLOVE SL, 1987, PSYCHOMETRIKA, V52, P333, DOI 10.1007/BF02294360
   Sobel ME., 1982, SOCIOL METHODOL, V13, P290, DOI DOI 10.2307/270723
   Sorbom D., 2001, STRUCTURAL EQUATION
   SPRINGER MD, 1966, SIAM J APPL MATH, V14, P511, DOI 10.1137/0114046
   Stansfeld SA, 1998, PSYCHOSOM MED, V60, P247, DOI 10.1097/00006842-199805000-00004
   Steffen PR, 2001, PSYCHOSOM MED, V63, P523, DOI 10.1097/00006842-200107000-00002
   Sullivan MD, 2001, PSYCHOSOM MED, V63, P248, DOI 10.1097/00006842-200103000-00008
   Taborga M. P., 2000, master's thesis
   TABORGA MP, 1999, 7 ANN M SOC PREV RES
   Thomas KS, 2006, PSYCHOSOM MED, V68, P692, DOI 10.1097/01.psy.0000238214.80871.e6
   Thomsen DK, 2004, PSYCHOSOM MED, V66, P363, DOI 10.1097/01.psy.0000127688.44363.fb
   Thurston RC, 2006, PSYCHOSOM MED, V68, P25, DOI 10.1097/01.psy.0000195883.68888.68
   Tofighi D., 2008, Advances in latent variable mixture models
   Van Tilburg MAL, 2001, PSYCHOSOM MED, V63, P551, DOI 10.1097/00006842-200107000-00005
   Vitaliano PP, 2005, PSYCHOSOM MED, V67, P930, DOI 10.1097/01.psy.0000188485.65153.7b
   von Eye A, 2009, INTEGR PSYCHOL BEHAV, V43, P228, DOI 10.1007/s12124-009-9088-9
   Waldinger RJ, 2006, PSYCHOSOM MED, V68, P129, DOI 10.1097/01.psy.0000195834.37094.a4
   Whiteman MC, 2000, PSYCHOSOM MED, V62, P703, DOI 10.1097/00006842-200009000-00015
   Williams J, 2008, STRUCT EQU MODELING, V15, P23, DOI 10.1080/10705510701758166
   Wilson RS, 2005, PSYCHOSOM MED, V67, P841, DOI 10.1097/01.psy.0000190615.20656.83
   WINSHIP C, 1983, AM J SOCIOL, V89, P54, DOI 10.1086/227834
   WOLCHIK SA, 1993, AM J COMMUN PSYCHOL, V21, P293, DOI 10.1007/BF00941505
   Wulsin LR, 1999, PSYCHOSOM MED, V61, P6, DOI 10.1097/00006842-199901000-00003
NR 139
TC 76
Z9 85
U1 4
U2 40
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JAN
PY 2011
VL 73
IS 1
BP 29
EP 43
DI 10.1097/PSY.0b013e318200a54b
PG 15
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 711BZ
UT WOS:000286562000005
PM 21148809
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Slavich, GM
   Irwin, MR
AF Slavich, George M.
   Irwin, Michael R.
TI From Stress to Inflammation and Major Depressive Disorder: A Social
   Signal Transduction Theory of Depression
SO PSYCHOLOGICAL BULLETIN
LA English
DT Article
DE early life stress; social threat; cytokines; mechanisms; disease
ID C-REACTIVE PROTEIN; TO-BRAIN COMMUNICATION; CORONARY-HEART-DISEASE;
   EARLY-LIFE STRESS; ARTERY RISK DEVELOPMENT; NF-KAPPA-B; PROINFLAMMATORY
   CYTOKINE PRODUCTION; INTERCELLULAR-ADHESION MOLECULE-1; EXCESSIVE
   REASSURANCE SEEKING; ADVERSE CHILDHOOD EXPERIENCES
AB Major life stressors, especially those involving interpersonal stress and social rejection, are among the strongest proximal risk factors for depression. In this review, we propose a biologically plausible, multilevel theory that describes neural, physiologic, molecular, and genomic mechanisms that link experiences of social-environmental stress with internal biological processes that drive depression pathogenesis. Central to this social signal transduction theory of depression is the hypothesis that experiences of social threat and adversity up-regulate components of the immune system involved in inflammation. The key mediators of this response, called proinflammatory cytokines, can in turn elicit profound changes in behavior, which include the initiation of depressive symptoms such as sad mood, anhedonia, fatigue, psychomotor retardation, and social-behavioral withdrawal. This highly conserved biological response to adversity is critical for survival during times of actual physical threat or injury. However, this response can also be activated by modern-day social, symbolic, or imagined threats, leading to an increasingly proinflammatory phenotype that may be a key phenomenon driving depression pathogenesis and recurrence, as well as the overlap of depression with several somatic conditions including asthma, rheumatoid arthritis, chronic pain, metabolic syndrome, cardiovascular disease, obesity, and neurodegeneration. Insights from this theory may thus shed light on several important questions including how depression develops, why it frequently recurs, why it is strongly predicted by early life stress, and why it often co-occurs with symptoms of anxiety and with certain physical disease conditions. This work may also suggest new opportunities for preventing and treating depression by targeting inflammation.
C1 [Slavich, George M.; Irwin, Michael R.] Univ Calif Los Angeles, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA 90095 USA.
   [Slavich, George M.; Irwin, Michael R.] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA.
C3 University of California System; University of California Los Angeles;
   University of California System; University of California Los Angeles
RP Slavich, GM (corresponding author), Univ Calif Los Angeles, Cousins Ctr Psychoneuroimmunol, UCLA Med Plaza 300,Room 3156, Los Angeles, CA 90095 USA.
EM gslavich@mednet.ucla.edu
RI Slavich, George/C-6208-2008; Irwin, Michael/H-4870-2013
OI Irwin, Michael/0000-0002-1502-8431
FU National Institutes of Health (NIH) [R01 CA140933]; Society in
   Science-Branco Weiss Fellowship; NIH [R01 AG034588, R01 AG026364, R01
   CA160245, R01 CA119159, R01 HL095799, R01 DA032922, P30 AG028748]; UCLA
   Clinical and Translational Science Institute [UL1 TR000124]; Cousins
   Center for Psychoneuroimmunology
FX George M. Slavich and Michael R. Irwin, Cousins Center for
   Psychoneuroimmunology and Department of Psychiatry and Biobehavioral
   Sciences, University of California, Los Angeles. Preparation of this
   review was supported by National Institutes of Health (NIH) Grant R01
   CA140933 and by a Society in Science-Branco Weiss Fellowship to George
   M. Slavich; by NIH Grants R01 AG034588, R01 AG026364, R01 CA160245, R01
   CA119159, R01 HL095799, R01 DA032922, and P30 AG028748 to Michael R.
   Irwin; and by seed grants from the UCLA Clinical and Translational
   Science Institute (UL1 TR000124) and the Cousins Center for
   Psychoneuroimmunology. We thank Keely Muscatell and Aoife O'Donovan for
   their very helpful comments on a previous version of the manuscript.
CR ADRIAN C, 1993, J CONSULT CLIN PSYCH, V61, P354, DOI 10.1037/0022-006X.61.2.354
   Agüera L, 2010, BMC FAM PRACT, V11, DOI 10.1186/1471-2296-11-17
   Ainsworth M., 1991, Attachment across the lifecycle, P33, DOI DOI 10.4324/9780203132470
   Akhondzadeh S, 2009, DEPRESS ANXIETY, V26, P607, DOI 10.1002/da.20589
   Akira S, 2001, NAT IMMUNOL, V2, P675, DOI 10.1038/90609
   Alexapoulos GS, 2005, LANCET, V365, P1961, DOI 10.1016/S0140-6736(05)66665-2
   Allen NB, 2003, PSYCHOL BULL, V129, P887, DOI 10.1037/0033-2909.129.6.887
   Amit I, 2009, SCIENCE, V326, P257, DOI 10.1126/science.1179050
   Anacker C, 2011, PSYCHONEUROENDOCRINO, V36, P415, DOI 10.1016/j.psyneuen.2010.03.007
   Andréasson A, 2007, BRAIN BEHAV IMMUN, V21, P147, DOI 10.1016/j.bbi.2006.08.002
   Andrews G, 2004, BRIT J PSYCHIAT, V184, P526, DOI 10.1192/bjp.184.6.526
   Anisman H, 1999, MOL PSYCHIATR, V4, P182, DOI 10.1038/sj.mp.4000436
   Anisman H, 2002, BRAIN BEHAV IMMUN, V16, P513, DOI 10.1016/S0889-1591(02)00009-0
   Anisman H, 2005, NEUROSCI BIOBEHAV R, V29, P525, DOI 10.1016/j.neubiorev.2005.03.007
   [Anonymous], 1996, BDI 2 BECK DEPRESSIO
   [Anonymous], 2000, DIAGN STAT MAN MENT
   Antoni MH, 2012, BIOL PSYCHIAT, V71, P366, DOI 10.1016/j.biopsych.2011.10.007
   Appleton AA, 2012, HEALTH PSYCHOL, V31, P413, DOI 10.1037/a0027300
   Appleton KM, 2010, AM J CLIN NUTR, V91, P757, DOI 10.3945/ajcn.2009.28313
   Aschbacher K, 2012, BRAIN BEHAV IMMUN, V26, P346, DOI 10.1016/j.bbi.2011.10.010
   Avitsur R, 2001, HORM BEHAV, V39, P247, DOI 10.1006/hbeh.2001.1653
   Backonja MM, 2008, J NEUROIMMUNOL, V195, P157, DOI 10.1016/j.jneuroim.2008.01.005
   Bair MJ, 2004, PSYCHOSOM MED, V66, P17, DOI 10.1097/01.PSY.0000106883.94059.C5
   Bair MJ, 2003, ARCH INTERN MED, V163, P2433, DOI 10.1001/archinte.163.20.2433
   Barnes PJ, 2009, LANCET, V373, P1905, DOI 10.1016/S0140-6736(09)60326-3
   Barth J, 2004, PSYCHOSOM MED, V66, P802, DOI 10.1097/01.psy.0000146332.53619.b2
   Barton GM, 2008, J CLIN INVEST, V118, P413, DOI 10.1172/JCI34431
   BAUMEISTER RF, 1995, PSYCHOL BULL, V117, P497, DOI 10.1037/0033-2909.117.3.497
   Baune BT, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.18
   Beck AT, 2008, AM J PSYCHIAT, V165, P969, DOI 10.1176/appi.ajp.2008.08050721
   Beck AaronT., 1967, Depression
   BERKENBOSCH F, 1987, SCIENCE, V238, P524, DOI 10.1126/science.2443979
   BERNSTEIN DP, 1994, AM J PSYCHIAT, V151, P1132, DOI 10.1176/ajp.151.8.1132
   BESEDOVSKY H, 1986, SCIENCE, V233, P652, DOI 10.1126/science.3014662
   Biddie SC, 2012, RHEUMATOLOGY, V51, P403, DOI 10.1093/rheumatology/ker215
   Bittner A, 2004, J CLIN PSYCHIAT, V65, P618
   Black DS, 2013, PSYCHONEUROENDOCRINO, V38, P348, DOI 10.1016/j.psyneuen.2012.06.011
   Blatt S., 2004, EXPERIENCES DEPRESSI, DOI [10.1037/10749-000, DOI 10.1037/10749-000]
   Borovikova LV, 2000, NATURE, V405, P458, DOI 10.1038/35013070
   Bower JE, 2014, CLIN PSYCHOL SCI, V2, P108, DOI 10.1177/2167702613496243
   Bower JE, 2011, BRAIN BEHAV IMMUN, V25, P147, DOI 10.1016/j.bbi.2010.09.010
   Bowlby J., 1980, Attachment and loss. Volume 3: Loss, sadness and depression, V3
   Boyce WT, 2012, P NATL ACAD SCI USA, V109, P17143, DOI 10.1073/pnas.1121264109
   Boyce WT, 2005, DEV PSYCHOPATHOL, V17, P271, DOI 10.1017/S0954579405050145
   BRADY EU, 1992, PSYCHOL BULL, V111, P244, DOI 10.1037/0033-2909.111.2.244
   Britton WB, 2012, BEHAV THER, V43, P365, DOI 10.1016/j.beth.2011.08.006
   Bromberger JT, 2009, PSYCHOL MED, V39, P55, DOI 10.1017/S0033291708003218
   Brown G.W., 1978, SOCIAL ORIGINS DEPRE
   Brown G.W., 1989, LIFE EVENTS ILLNESS
   BROWN GW, 1995, PSYCHOL MED, V25, P7, DOI 10.1017/S003329170002804X
   Bryclon L, 2008, BIOL PSYCHIAT, V63, P1022, DOI 10.1016/j.biopsych.2007.12.007
   Bufalino C, 2013, BRAIN BEHAV IMMUN, V31, P31, DOI 10.1016/j.bbi.2012.04.009
   Bull SJ, 2009, MOL PSYCHIATR, V14, P1095, DOI 10.1038/mp.2008.48
   Burke JD, 2005, J CHILD PSYCHOL PSYC, V46, P1200, DOI 10.1111/j.1469-7610.2005.00422.x
   Burstein M, 2012, J CONSULT CLIN PSYCH, V80, P102, DOI 10.1037/a0026069
   Calder PC, 2006, AM J CLIN NUTR, V83, p1505S, DOI 10.1093/ajcn/83.6.1505S
   Camacho-Arroyo I, 2009, NEUROIMMUNOMODULAT, V16, P1, DOI 10.1159/000179661
   Campbell J, 2012, PSYCHONEUROENDOCRINO, V37, P1111, DOI 10.1016/j.psyneuen.2011.12.010
   Capuron L, 2005, BIOL PSYCHIAT, V58, P190, DOI 10.1016/j.biopsych.2005.03.033
   Capuron L, 2004, BIOL PSYCHIAT, V56, P819, DOI 10.1016/j.biopsych.2004.02.009
   Capuron L, 2003, AM J PSYCHIAT, V160, P1342, DOI 10.1176/appi.ajp.160.7.1342
   Capuron L, 2002, NEUROPSYCHOPHARMACOL, V26, P643, DOI 10.1016/S0893-133X(01)00407-9
   Capuron L, 2001, PSYCHOSOM MED, V63, P376, DOI 10.1097/00006842-200105000-00007
   Capuron L, 2007, NEUROPSYCHOPHARMACOL, V32, P2384, DOI 10.1038/sj.npp.1301362
   Capuron L, 2012, ARCH GEN PSYCHIAT, V69, P1044, DOI 10.1001/archgenpsychiatry.2011.2094
   Capuron L, 2011, PHARMACOL THERAPEUT, V130, P226, DOI 10.1016/j.pharmthera.2011.01.014
   Capuron L, 2011, BIOL PSYCHIAT, V70, P175, DOI 10.1016/j.biopsych.2010.12.006
   Carpenter LL, 2012, ACTA PSYCHIAT SCAND, V126, P402, DOI 10.1111/j.1600-0447.2012.01892.x
   Carpenter LL, 2010, NEUROPSYCHOPHARMACOL, V35, P2617, DOI 10.1038/npp.2010.159
   Carroll JE, 2013, P NATL ACAD SCI USA, V110, P17149, DOI 10.1073/pnas.1315458110
   Carroll JE, 2011, BRAIN BEHAV IMMUN, V25, P1468, DOI 10.1016/j.bbi.2011.05.016
   Carroll JE, 2011, BRAIN BEHAV IMMUN, V25, P232, DOI 10.1016/j.bbi.2010.09.024
   Caspi A, 2003, SCIENCE, V301, P386, DOI 10.1126/science.1083968
   Castanon N, 2001, PSYCHOPHARMACOLOGY, V154, P50, DOI 10.1007/s002130000595
   Chen E, 2009, THORAX, V64, P38, DOI 10.1136/thx.2007.095091
   Chen E, 2011, MOL PSYCHIATR, V16, P729, DOI 10.1038/mp.2010.53
   Chen E, 2007, BRAIN BEHAV IMMUN, V21, P993, DOI 10.1016/j.bbi.2007.03.009
   Chiang JJ, 2012, P NATL ACAD SCI USA, V109, P1878, DOI 10.1073/pnas.1120972109
   Chisholm D, 2004, BRIT J PSYCHIAT, V184, P393, DOI 10.1192/bjp.184.5.393
   Chiu IM, 2012, NAT NEUROSCI, V15, P1063, DOI 10.1038/nn.3144
   Cho HJ, 2012, BRAIN BEHAV IMMUN, V26, P859, DOI 10.1016/j.bbi.2012.04.005
   Choy EHS, 2001, NEW ENGL J MED, V344, P907, DOI 10.1056/NEJM200103223441207
   Chrousos GP, 2009, NAT REV ENDOCRINOL, V5, P374, DOI 10.1038/nrendo.2009.106
   Cicchetti D, 2005, ANNU REV CLIN PSYCHO, V1, P409, DOI 10.1146/annurev.clinpsy.1.102803.144029
   CLARK LA, 1991, J ABNORM PSYCHOL, V100, P316, DOI 10.1037/0021-843X.100.3.316
   Cohen S, 2007, JAMA-J AM MED ASSOC, V298, P1685, DOI 10.1001/jama.298.14.1685
   Cohen S, 2012, P NATL ACAD SCI USA, V109, P5995, DOI 10.1073/pnas.1118355109
   Cole DA, 1998, J CONSULT CLIN PSYCH, V66, P451, DOI 10.1037/0022-006X.66.3.451
   Cole SW, 2008, BRAIN BEHAV IMMUN, V22, P1049, DOI 10.1016/j.bbi.2008.02.006
   Cole SW, 2007, GENOME BIOL, V8, DOI 10.1186/gb-2007-8-9-r189
   Cole SW, 2010, PSYCHONEUROENDOCRINO, V35, P955, DOI 10.1016/j.psyneuen.2010.06.008
   Cole SW, 2009, CURR DIR PSYCHOL SCI, V18, P132, DOI 10.1111/j.1467-8721.2009.01623.x
   Cole SW, 2012, P NATL ACAD SCI USA, V109, P20578, DOI 10.1073/pnas.1218253109
   Cole SW, 2011, P NATL ACAD SCI USA, V108, P3080, DOI 10.1073/pnas.1014218108
   Cole SW, 2010, P NATL ACAD SCI USA, V107, P5681, DOI 10.1073/pnas.0911515107
   Cole SW, 1998, J IMMUNOL, V161, P610
   Cole SW., 2012, The Oxford Handbook of Psychoneuroimmunology, P254
   Collado-Hidalgo A, 2006, BRAIN BEHAV IMMUN, V20, P552, DOI 10.1016/j.bbi.2006.01.005
   Couzin-Frankel J, 2010, SCIENCE, V330, P1621, DOI 10.1126/science.330.6011.1621
   COVER H, 1994, J BEHAV MED, V17, P217, DOI 10.1007/BF01858106
   COYNE JC, 1991, ANNU REV PSYCHOL, V42, P401, DOI 10.1146/annurev.ps.42.020191.002153
   Cramer AOJ, 2012, PSYCHOL MED, V42, P957, DOI 10.1017/S003329171100211X
   Creswell JD, 2012, BRAIN BEHAV IMMUN, V26, P1095, DOI 10.1016/j.bbi.2012.07.006
   Curfs JHAJ, 1997, CLIN MICROBIOL REV, V10, P742, DOI 10.1128/CMR.10.4.742
   Cutolo M, 2006, NEUROIMMUNOMODULAT, V13, P277, DOI 10.1159/000104855
   Danese A, 2011, MOL PSYCHIATR, V16, P244, DOI 10.1038/mp.2010.5
   Danese A, 2008, ARCH GEN PSYCHIAT, V65, P409, DOI 10.1001/archpsyc.65.4.409
   Danese A, 2007, P NATL ACAD SCI USA, V104, P1319, DOI 10.1073/pnas.0610362104
   Danese A, 2012, PHYSIOL BEHAV, V106, P29, DOI 10.1016/j.physbeh.2011.08.019
   DANTZER R, 1989, LIFE SCI, V44, P1995, DOI 10.1016/0024-3205(89)90345-7
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   Dantzer R, 2007, BRAIN BEHAV IMMUN, V21, P153, DOI 10.1016/j.bbi.2006.09.006
   Dantzer R, 2011, PSYCHONEUROENDOCRINO, V36, P426, DOI 10.1016/j.psyneuen.2010.09.012
   de Graaf R, 2003, SOC PSYCH PSYCH EPID, V38, P1, DOI 10.1007/s00127-003-0597-4
   De La Garza R, 2005, NEUROSCI BIOBEHAV R, V29, P761, DOI 10.1016/j.neubiorev.2005.03.016
   Debnath M, 2011, TRANSL NEUROSCI, V2, P121, DOI 10.2478/s13380-011-0019-0
   DellaGioia N, 2010, NEUROSCI BIOBEHAV R, V34, P130, DOI 10.1016/j.neubiorev.2009.07.014
   Denson TF, 2009, PSYCHOL BULL, V135, P823, DOI 10.1037/a0016909
   DESSER L, 1994, CANCER BIOTHERAPY, V9, P253, DOI 10.1089/cbr.1994.9.253
   Deverts DJ, 2012, BRAIN BEHAV IMMUN, V26, P1128, DOI 10.1016/j.bbi.2012.07.017
   DeWall CN, 2010, PSYCHOL SCI, V21, P931, DOI 10.1177/0956797610374741
   Dhabhar FS, 2012, PSYCHONEUROENDOCRINO, V37, P1345, DOI 10.1016/j.psyneuen.2012.05.008
   Dhabhar FS, 2009, J PSYCHIATR RES, V43, P962, DOI 10.1016/j.jpsychires.2009.05.010
   Dhabhar FS, 2009, NEUROIMMUNOMODULAT, V16, P300, DOI 10.1159/000216188
   Dickerson SS, 2008, HEALTH PSYCHOL, V27, P116, DOI 10.1037/0278-6133.27.1.116
   Dickerson SS, 2009, SELF IDENTITY, V8, P270, DOI 10.1080/15298860802505186
   Dickerson SS, 2009, PSYCHOL SCI, V20, P1237, DOI 10.1111/j.1467-9280.2009.02437.x
   Dickerson SS, 2004, PSYCHOSOM MED, V66, P124, DOI 10.1097/01.PSY.0000097338.75454.29
   Dickerson SS, 2004, PSYCHOL BULL, V130, P355, DOI 10.1037/0033-2909.130.3.355
   Dohrenwend BP, 2006, PSYCHOL BULL, V132, P477, DOI 10.1037/0033-2909.132.3.477
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Duivis HE, 2011, AM J PSYCHIAT, V168, P913, DOI 10.1176/appi.ajp.2011.10081163
   Duman RS, 2012, SCIENCE, V338, P68, DOI 10.1126/science.1222939
   Eaton WW, 2008, ARCH GEN PSYCHIAT, V65, P513, DOI 10.1001/archpsyc.65.5.513
   Edwards KM, 2006, BRAIN BEHAV IMMUN, V20, P159, DOI 10.1016/j.bbi.2005.07.001
   Eiland L, 2013, NEUROSCIENCE, V249, P162, DOI 10.1016/j.neuroscience.2012.10.048
   Eisenberger NI, 2012, NAT REV NEUROSCI, V13, P421, DOI 10.1038/nrn3231
   Eisenberger NI, 2012, NAT NEUROSCI, V15, P669, DOI 10.1038/nn.3086
   Eisenberger NI, 2012, PSYCHOSOM MED, V74, P126, DOI 10.1097/PSY.0b013e3182464dd1
   Eisenberger NI, 2010, BIOL PSYCHIAT, V68, P748, DOI 10.1016/j.biopsych.2010.06.010
   Eisenberger NI, 2010, BRAIN BEHAV IMMUN, V24, P558, DOI 10.1016/j.bbi.2009.12.009
   Eisenberger NI, 2009, NEUROIMAGE, V47, P881, DOI 10.1016/j.neuroimage.2009.04.040
   Engler H, 2005, J NEUROIMMUNOL, V163, P110, DOI 10.1016/j.jneuroim.2005.03.002
   Essau CA, 2003, DEPRESS ANXIETY, V18, P1, DOI 10.1002/da.10107
   Essau CA, 2008, PSYCHIAT RES, V158, P35, DOI 10.1016/j.psychres.2007.09.007
   Evans GW, 2010, ANN NY ACAD SCI, V1186, P174, DOI 10.1111/j.1749-6632.2009.05336.x
   Evraire LE, 2011, CLIN PSYCHOL REV, V31, P1291, DOI 10.1016/j.cpr.2011.07.014
   Fagundes CP, 2011, SOC PERSONAL PSYCHOL, V5, P891, DOI 10.1111/j.1751-9004.2011.00392.x
   Fanous AH, 2005, MOL PSYCHIATR, V10, P6, DOI 10.1038/sj.mp.4001571
   Farmer AE, 2003, PSYCHOL MED, V33, P1169, DOI 10.1017/S0033291703008419
   Felger JC, 2011, BRAIN BEHAV IMMUN, V25, P1094, DOI 10.1016/j.bbi.2011.02.015
   Felitti VJ, 1998, AM J PREV MED, V14, P245, DOI 10.1016/S0749-3797(98)00017-8
   Fernald RD, 2012, P NATL ACAD SCI USA, V109, P17194, DOI 10.1073/pnas.1202552109
   First M.B., 2016, Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version
   Fishman D, 1998, J CLIN INVEST, V102, P1369, DOI 10.1172/JCI2629
   Ford ES, 2006, ANN EPIDEMIOL, V16, P78, DOI 10.1016/j.annepidem.2005.08.005
   Fredrickson BL, 2013, P NATL ACAD SCI USA, V110, P13684, DOI 10.1073/pnas.1305419110
   Freud S., 1957, The standard edition of the complete phsychological works of Sigmund Freud, V14, P152
   Fries E, 2005, PSYCHONEUROENDOCRINO, V30, P1010, DOI 10.1016/j.psyneuen.2005.04.006
   Frommberger UH, 1997, EUR ARCH PSY CLIN N, V247, P228, DOI 10.1007/BF02900219
   Fuligni AJ, 2009, PSYCHOSOM MED, V71, P329, DOI 10.1097/PSY.0b013e3181921b1f
   Gabbay V, 2009, J AFFECT DISORDERS, V115, P177, DOI 10.1016/j.jad.2008.07.022
   Galecki P, 2012, J AFFECT DISORDERS, V138, P360, DOI 10.1016/j.jad.2012.01.016
   Garber J, 2010, CLIN PSYCHOL-SCI PR, V17, P293, DOI 10.1111/j.1468-2850.2010.01221.x
   GIACONIA RM, 1994, J AM ACAD CHILD PSY, V33, P706, DOI 10.1097/00004583-199406000-00012
   Gibson G, 2008, NAT REV GENET, V9, P575, DOI 10.1038/nrg2383
   Gilbert P., 1992, DEPRESSION EVOLUTION
   Gilman SE, 2003, AM J PSYCHIAT, V160, P939, DOI 10.1176/appi.ajp.160.5.939
   Gimeno D, 2009, PSYCHOL MED, V39, P413, DOI 10.1017/S0033291708003723
   Gimeno D, 2007, EUR J EPIDEMIOL, V22, P675, DOI 10.1007/s10654-007-9171-9
   Glaser R, 2005, NAT REV IMMUNOL, V5, P243, DOI 10.1038/nri1571
   Glass CK, 2010, CELL, V140, P918, DOI 10.1016/j.cell.2010.02.016
   Gluckman PD, 2008, NEW ENGL J MED, V359, P61, DOI 10.1056/NEJMra0708473
   Goldman-Mellor S, 2010, PSYCHOL MED, V40, P2079, DOI 10.1017/S0033291710000267
   Goodwin RD, 2004, PSYCHOL MED, V34, P1465, DOI 10.1017/S0033291704002739
   Gotlib IH, 2010, ANNU REV CLIN PSYCHO, V6, P285, DOI 10.1146/annurev.clinpsy.121208.131305
   Gouin JP, 2012, ANN BEHAV MED, V44, P287, DOI 10.1007/s12160-012-9386-1
   Graff LA, 2009, INFLAMM BOWEL DIS, V15, P1105, DOI 10.1002/ibd.20873
   Grebe KM, 2010, J IMMUNOL, V184, P540, DOI 10.4049/jimmunol.0903395
   Green JG, 2010, ARCH GEN PSYCHIAT, V67, P113, DOI 10.1001/archgenpsychiatry.2009.186
   Greenberg PE, 2003, J CLIN PSYCHIAT, V64, P1465, DOI 10.4088/JCP.v64n1211
   Griffith JW, 2010, PSYCHOL MED, V40, P1125, DOI 10.1017/S0033291709991449
   Grisanti LA, 2011, J PHARMACOL EXP THER, V338, P648, DOI 10.1124/jpet.110.178012
   Gruenewald TL, 2009, SOC SCI MED, V69, P451, DOI 10.1016/j.socscimed.2009.05.018
   Gruys E, 2005, J Zhejiang Univ Sci B, V6, P1045, DOI 10.1631/jzus.2005.B1045
   Gunnar M, 2007, ANNU REV PSYCHOL, V58, P145, DOI 10.1146/annurev.psych.58.110405.085605
   Hackett RA, 2012, PSYCHONEUROENDOCRINO, V37, P1801, DOI 10.1016/j.psyneuen.2012.03.016
   Häfner S, 2011, BRAIN BEHAV IMMUN, V25, P1701, DOI 10.1016/j.bbi.2011.06.017
   Hamer M, 2009, BRAIN BEHAV IMMUN, V23, P413, DOI 10.1016/j.bbi.2009.01.005
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Hammen C, 2000, J CONSULT CLIN PSYCH, V68, P782, DOI 10.1037/0022-006X.68.5.782
   HAMMEN C, 1991, J ABNORM PSYCHOL, V100, P555, DOI 10.1037/0021-843X.100.4.555
   Hammen C, 2005, ANNU REV CLIN PSYCHO, V1, P293, DOI 10.1146/annurev.clinpsy.1.102803.143938
   Hanke ML, 2012, BRAIN BEHAV IMMUN, V26, P1150, DOI 10.1016/j.bbi.2012.07.011
   Hankin BL, 2001, PSYCHOL BULL, V127, P773, DOI 10.1037//0033-2909.127.6.773
   Hannestad J, 2011, BRAIN BEHAV IMMUN, V25, P256, DOI 10.1016/j.bbi.2010.10.013
   Harkness KL, 2006, J ABNORM PSYCHOL, V115, P730, DOI 10.1037/0021-843X.115.4.730
   Harkness KL, 2010, J ABNORM PSYCHOL, V119, P791, DOI 10.1037/a0020629
   Haroon E, 2012, NEUROPSYCHOPHARMACOL, V37, P137, DOI 10.1038/npp.2011.205
   Harrison NA, 2009, BIOL PSYCHIAT, V66, P415, DOI 10.1016/j.biopsych.2009.03.007
   Harrison NA, 2009, BIOL PSYCHIAT, V66, P407, DOI 10.1016/j.biopsych.2009.03.015
   HART BL, 1988, NEUROSCI BIOBEHAV R, V12, P123, DOI 10.1016/S0149-7634(88)80004-6
   Hayley S, 2011, FRONT BEHAV NEUROSCI, V5, DOI 10.3389/fnbeh.2011.00019
   Hazel NA, 2008, PSYCHOL MED, V38, P581, DOI 10.1017/S0033291708002857
   Heffner KL, 2011, SOC SCI MED, V72, P1482, DOI 10.1016/j.socscimed.2011.03.016
   Heim C, 1997, ANN NY ACAD SCI, V821, P194, DOI 10.1111/j.1749-6632.1997.tb48279.x
   Hennessy MB, 2009, CURR DIR PSYCHOL SCI, V18, P227, DOI 10.1111/j.1467-8721.2009.01641.x
   HERBERT TB, 1993, PSYCHOL BULL, V113, P472, DOI 10.1037/0033-2909.113.3.472
   HERBERT TB, 1993, PSYCHOSOM MED, V55, P364, DOI 10.1097/00006842-199307000-00004
   Hernández ME, 2008, EUR NEUROPSYCHOPHARM, V18, P917, DOI 10.1016/j.euroneuro.2008.08.001
   Hertzman C, 1999, ANN NY ACAD SCI, V896, P85, DOI 10.1111/j.1749-6632.1999.tb08107.x
   Hiles SA, 2012, BRAIN BEHAV IMMUN, V26, P1180, DOI 10.1016/j.bbi.2012.06.001
   Himmerich H, 2008, EUR PSYCHIAT, V23, P421, DOI 10.1016/j.eurpsy.2008.03.013
   Hofmann SG, 2010, J CONSULT CLIN PSYCH, V78, P169, DOI 10.1037/a0018555
   Holt-Lunstad J, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000316
   Holtzheimer PE, 2011, TRENDS NEUROSCI, V34, P1, DOI 10.1016/j.tins.2010.10.004
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Huang JL, 2012, INFLAMMATION, V35, P527, DOI 10.1007/s10753-011-9342-4
   Hubbard AK, 2000, FREE RADICAL BIO MED, V28, P1379, DOI 10.1016/S0891-5849(00)00223-9
   IRWIN M, 1991, FASEB J, V5, P3100, DOI 10.1096/fasebj.5.15.1743441
   Irwin MR, 2007, BRAIN BEHAV IMMUN, V21, P374, DOI 10.1016/j.bbi.2007.01.010
   Irwin MR, 2013, CLIN INFECT DIS, V56, P1085, DOI 10.1093/cid/cis1208
   Irwin MR, 2012, AM J GERIAT PSYCHIAT, V20, P764, DOI 10.1097/JGP.0b013e3182330fd3
   Irwin MR, 2011, NAT REV IMMUNOL, V11, P625, DOI 10.1038/nri3042
   Irwin MR, 2011, BRAIN BEHAV IMMUN, V25, P759, DOI 10.1016/j.bbi.2011.02.001
   Ishii S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036062
   Jain S., 2007, Encyclopedia of Stress, V1, P698, DOI DOI 10.1016/B978-012373947-6.00727-3
   JANSSEN HLA, 1994, J HEPATOL, V21, P241, DOI 10.1016/S0168-8278(05)80402-7
   Jarcho MR, 2013, BIOL PSYCHOL, V93, P150, DOI 10.1016/j.biopsycho.2013.01.018
   Jaremka LM, 2013, PSYCHOL SCI, V24, P1089, DOI 10.1177/0956797612464059
   Joiner TE, 1999, PSYCHOL INQ, V10, P269, DOI 10.1207/S15327965PLI1004_1
   Joiner TE, 2001, PSYCHOL SCI, V12, P371, DOI 10.1111/1467-9280.00369
   Karg K, 2011, ARCH GEN PSYCHIAT, V68, P444, DOI 10.1001/archgenpsychiatry.2010.189
   Karin M, 2006, NATURE, V441, P431, DOI 10.1038/nature04870
   KATZ PP, 1993, J RHEUMATOL, V20, P790
   Kawai T, 2007, J BIOCHEM, V141, P137, DOI 10.1093/jb/mvm032
   Keller MC, 2007, AM J PSYCHIAT, V164, P1521, DOI 10.1176/appi.ajp.2007.06091564
   Kemeny ME, 2009, BRAIN BEHAV IMMUN, V23, P1, DOI 10.1016/j.bbi.2008.08.008
   Kendler KS, 2000, AM J PSYCHIAT, V157, P1243, DOI 10.1176/appi.ajp.157.8.1243
   Kendler KS, 2003, ARCH GEN PSYCHIAT, V60, P789, DOI 10.1001/archpsyc.60.8.789
   Kendler KS, 2002, AM J PSYCHIAT, V159, P1133, DOI 10.1176/appi.ajp.159.7.1133
   KENDLER KS, 1993, AM J PSYCHIAT, V150, P1139
   KENDLER KS, 1995, AM J PSYCHIAT, V152, P833
   Kendler KS, 1999, AM J PSYCHIAT, V156, P837, DOI 10.1176/ajp.156.6.837
   Kessler RC, 2010, PSYCHOL MED, V40, P225, DOI 10.1017/S0033291709990213
   Kiecolt-Glaser JK, 2011, BRAIN BEHAV IMMUN, V25, P1725, DOI 10.1016/j.bbi.2011.07.229
   Kiecolt-Glaser JK, 2011, PSYCHOSOM MED, V73, P16, DOI 10.1097/PSY.0b013e31820573b6
   Kiecolt-Glaser JK, 2010, NEUROSCI BIOBEHAV R, V35, P33, DOI 10.1016/j.neubiorev.2009.09.003
   Kiecolt-Glaser JK, 2010, PSYCHOSOM MED, V72, P113, DOI 10.1097/PSY.0b013e3181cb9377
   Kiecolt-Glaser JK, 2005, ARCH GEN PSYCHIAT, V62, P1377, DOI 10.1001/archpsyc.62.12.1377
   Kim S, 2011, PSYCHOL BULL, V137, P68, DOI 10.1037/a0021466
   Kircanski K, 2012, WIRES COGN SCI, V3, P301, DOI 10.1002/wcs.1177
   KIRSCHBAUM C, 1993, NEUROPSYCHOBIOLOGY, V28, P76, DOI 10.1159/000119004
   Kivimäki M, 2006, SCAND J WORK ENV HEA, V32, P431, DOI 10.5271/sjweh.1049
   Konsman JP, 2002, TRENDS NEUROSCI, V25, P154, DOI 10.1016/S0166-2236(00)02088-9
   Krueger RE, 2006, ANNU REV CLIN PSYCHO, V2, P111, DOI 10.1146/annurev.clinpsy.2.022305.095213
   Kuo HK, 2005, LANCET NEUROL, V4, P371, DOI 10.1016/S1474-4422(05)70099-5
   Kupper N, 2012, J AFFECT DISORDERS, V136, P567, DOI 10.1016/j.jad.2011.10.029
   KUSHNER I, 1982, ANN NY ACAD SCI, V389, P39, DOI 10.1111/j.1749-6632.1982.tb22124.x
   Lane RD, 2009, PSYCHOSOM MED, V71, P117, DOI 10.1097/PSY.0b013e31819783be
   Lavretsky H, 2011, AM J GERIAT PSYCHIAT, V19, P839, DOI 10.1097/JGP.0b013e31820ee9ef
   Lee HJ, 2000, J EXP MED, V192, P105, DOI 10.1084/jem.192.1.105
   Leonard B, 2012, NEUROSCI BIOBEHAV R, V36, P764, DOI 10.1016/j.neubiorev.2011.12.005
   Leonard Brian E., 2010, Current Immunology Reviews, V6, P205
   Lewinsohn PM, 1997, J ANXIETY DISORD, V11, P377, DOI 10.1016/S0887-6185(97)00017-0
   LEWINSOHN PM, 1994, J AM ACAD CHILD PSY, V33, P809, DOI 10.1097/00004583-199407000-00006
   Li M, 2011, CURR PSYCHIAT REP, V13, P316, DOI 10.1007/s11920-011-0210-6
   Libert C, 2003, NATURE, V421, P328, DOI 10.1038/421328a
   Loeser JD, 1999, LANCET, V353, P1607, DOI 10.1016/S0140-6736(99)01311-2
   Lotrich FE, 2007, J PSYCHOSOM RES, V63, P131, DOI 10.1016/j.jpsychores.2007.05.013
   Lotrich FE, 2011, J RHEUMATOL, V38, P48, DOI 10.3899/jrheum.110903
   Lotrich FE, 2009, BIOL PSYCHIAT, V65, P344, DOI 10.1016/j.biopsych.2008.08.009
   Lutgendorf SK, 2013, GYNECOL ONCOL, V131, P667, DOI 10.1016/j.ygyno.2013.09.025
   Lutgendorf SK, 2012, J CLIN ONCOL, V30, P2885, DOI 10.1200/JCO.2011.39.4411
   Lutgendorf SK, 2009, BRAIN BEHAV IMMUN, V23, P176, DOI 10.1016/j.bbi.2008.04.155
   Ma SH, 2004, J CONSULT CLIN PSYCH, V72, P31, DOI 10.1037/0022-006X.72.1.31
   MAES M, 1995, PSYCHONEUROENDOCRINO, V20, P111, DOI 10.1016/0306-4530(94)00066-J
   Maes M, 1996, BIOL PSYCHIAT, V40, P1273
   MAES M, 1995, PROG NEURO-PSYCHOPH, V19, P11, DOI 10.1016/0278-5846(94)00101-M
   Maes M, 1999, ADV EXP MED BIOL, V461, P25
   Maes M, 2011, PROG NEURO-PSYCHOPH, V35, P702, DOI 10.1016/j.pnpbp.2010.12.017
   MAES M, 1994, PSYCHIAT RES, V54, P143, DOI 10.1016/0165-1781(94)90003-5
   MAES M, 1992, PSYCHOL MED, V22, P45, DOI 10.1017/S0033291700032712
   Maes M, 1993, Rev Neurosci, V4, P407
   Maes M, 2011, PROG NEURO-PSYCHOPH, V35, P664, DOI 10.1016/j.pnpbp.2010.06.014
   Maier SF, 1998, PSYCHOL REV, V105, P83, DOI 10.1037/0033-295X.105.1.83
   Mantovani A, 2008, NATURE, V454, P436, DOI 10.1038/nature07205
   Marchand F, 2005, NAT REV NEUROSCI, V6, P521, DOI 10.1038/nrn1700
   Marin TJ, 2009, PSYCHOSOM MED, V71, P378, DOI 10.1097/PSY.0b013e318199dbc3
   Marques AH, 2009, ANN NY ACAD SCI, V1179, P1, DOI 10.1111/j.1749-6632.2009.04987.x
   Marques-Deak AH, 2007, J PSYCHIATR RES, V41, P152, DOI 10.1016/j.jpsychires.2005.11.003
   Marsland AL, 2013, PSYCHOSOM MED, V75, P438, DOI 10.1097/PSY.0b013e3182983ea6
   Marx J, 2004, SCIENCE, V306, P966, DOI 10.1126/science.306.5698.966
   Masten CL, 2011, DEV PSYCHOPATHOL, V23, P283, DOI 10.1017/S0954579410000799
   Matthews KA, 2010, BRAIN BEHAV IMMUN, V24, P96, DOI 10.1016/j.bbi.2009.08.005
   Mattson MP, 2004, TRENDS NEUROSCI, V27, P589, DOI 10.1016/j.tins.2004.08.001
   Mays JW, 2010, J IMMUNOL, V184, P2014, DOI 10.4049/jimmunol.0900183
   Mazure CM, 1998, CLIN PSYCHOL-SCI PR, V5, P291, DOI 10.1111/j.1468-2850.1998.tb00151.x
   McCrory E, 2010, J CHILD PSYCHOL PSYC, V51, P1079, DOI 10.1111/j.1469-7610.2010.02271.x
   McEwen BS, 2008, EUR J PHARMACOL, V583, P174, DOI 10.1016/j.ejphar.2007.11.071
   McEwen BS, 2007, PHYSIOL REV, V87, P873, DOI 10.1152/physrev.00041.2006
   McEwen Bruce S, 2010, Ann N Y Acad Sci, V1204 Suppl, pE38, DOI 10.1111/j.1749-6632.2010.05568.x
   McEwen BS, 2010, ANN NY ACAD SCI, V1186, P190, DOI 10.1111/j.1749-6632.2009.05331.x
   McEwen BS, 1999, ANN NY ACAD SCI, V896, P30, DOI 10.1111/j.1749-6632.1999.tb08103.x
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   Medzhitov R, 2001, NAT REV IMMUNOL, V1, P135, DOI 10.1038/35100529
   Medzhitov R, 2008, NATURE, V454, P428, DOI 10.1038/nature07201
   Medzhitov R, 2007, NATURE, V449, P819, DOI 10.1038/nature06246
   Mendlewicz J, 2006, INT CLIN PSYCHOPHARM, V21, P227, DOI 10.1097/00004850-200607000-00005
   Messay B, 2012, BIOL MOOD ANXIETY DI, V2, DOI [10.1186/2045-5380-2-4, 10.1186/PREACCEPT-1461493759628561]
   Miller AH, 2008, BRAIN BEHAV IMMUN, V22, P22, DOI 10.1016/j.bbi.2007.08.003
   Miller AH, 2009, BIOL PSYCHIAT, V65, P732, DOI 10.1016/j.biopsych.2008.11.029
   Miller GE, 2006, P NATL ACAD SCI USA, V103, P5496, DOI 10.1073/pnas.0506312103
   Miller GE, 2005, PSYCHOSOM MED, V67, P679, DOI 10.1097/01.psy.0000174172.82428.ce
   Miller GE, 2002, HEALTH PSYCHOL, V21, P531, DOI 10.1037//0278-6133.21.6.531
   Miller G, 2007, PSYCHOSOM MED, V69, P402, DOI 10.1097/PSY.0b013e318068fcf9
   Miller G, 2009, ANNU REV PSYCHOL, V60, P501, DOI 10.1146/annurev.psych.60.110707.163551
   Miller GE, 2008, BIOL PSYCHIAT, V64, P266, DOI 10.1016/j.biopsych.2008.03.017
   Miller GE, 2012, BIOL PSYCHIAT, V72, P34, DOI 10.1016/j.biopsych.2012.02.034
   Miller GE, 2011, PSYCHOL BULL, V137, P959, DOI 10.1037/a0024768
   Miller GE, 2010, PSYCHOL SCI, V21, P848, DOI 10.1177/0956797610370161
   Miller GE, 2009, P NATL ACAD SCI USA, V106, P14716, DOI 10.1073/pnas.0902971106
   Miller GE, 2009, PSYCHOSOM MED, V71, P57, DOI 10.1097/PSY.0b013e318190d7de
   MILLER NE, 1964, B BRIT PSYCHOL SOC, V17, P1
   Monk JP, 2006, J CLIN ONCOL, V24, P1852, DOI 10.1200/JCO.2005.04.2838
   Monroe S.M., 2007, Encyclopedia of stress, V3, P278, DOI DOI 10.1016/B978-012373947-6.00317-2
   Monroe S.M., 2009, HDB DEPRESSION, V2nd, P340
   Monroe SM, 2008, ANNU REV CLIN PSYCHO, V4, P33, DOI 10.1146/annurev.clinpsy.4.022007.141207
   Monroe SM, 2007, PSYCHOL MED, V37, P863, DOI 10.1017/S0033291707000281
   Monroe SM, 2007, J ABNORM PSYCHOL, V116, P116, DOI 10.1037/0021-843X.116.1.116
   Monroe SM, 2014, J PSYCHIATR RES, V49, P90, DOI 10.1016/j.jpsychires.2013.11.005
   Monroe SM, 2011, PSYCHOL REV, V118, P655, DOI 10.1037/a0025190
   Monroe SM, 2005, PSYCHOL REV, V112, P417, DOI 10.1037/0033-295X.112.2.417
   MONROE SM, 1991, PSYCHOL BULL, V110, P406, DOI 10.1037/0033-2909.110.3.406
   Monroe SM, 1999, J ABNORM PSYCHOL, V108, P606, DOI 10.1037/0021-843X.108.4.606
   Moons WG, 2010, BRAIN BEHAV IMMUN, V24, P215, DOI 10.1016/j.bbi.2009.08.009
   Motivala SJ, 2006, J GERONTOL A-BIOL, V61, P1177, DOI 10.1093/gerona/61.11.1177
   Müller N, 2006, MOL PSYCHIATR, V11, P680, DOI 10.1038/sj.mp.4001805
   Murphy K., 2011, JANEWAYS IMMUNOBIOL
   Murphy MLM, 2013, CLIN PSYCHOL SCI, V1, P30, DOI 10.1177/2167702612455743
   Muscatell KA, 2012, SOC PERSONAL PSYCHOL, V6, P890, DOI 10.1111/j.1751-9004.2012.00467.x
   Muscatell KA, 2009, J NERV MENT DIS, V197, P154, DOI 10.1097/NMD.0b013e318199f77b
   Musselman DL, 2001, NEW ENGL J MED, V344, P961, DOI 10.1056/NEJM200103293441303
   Nance DM, 2007, BRAIN BEHAV IMMUN, V21, P736, DOI 10.1016/j.bbi.2007.03.008
   Nedeljkovic M, 2012, PSYCHONEUROENDOCRINO, V37, P1171, DOI 10.1016/j.psyneuen.2011.12.007
   O'Connor JC, 2009, MOL PSYCHIATR, V14, P511, DOI 10.1038/sj.mp.4002148
   O'Connor MF, 2012, PSYCHONEUROENDOCRINO, V37, P725, DOI 10.1016/j.psyneuen.2011.08.009
   O'Donovan A, 2013, DEPRESS ANXIETY, V30, P307, DOI 10.1002/da.22087
   O'Donovan A, 2013, NEUROSCI BIOBEHAV R, V37, P96, DOI 10.1016/j.neubiorev.2012.10.013
   O'Donovan A, 2012, BRAIN BEHAV IMMUN, V26, P573, DOI 10.1016/j.bbi.2012.01.007
   O'Donovan A, 2011, DIS MARKERS, V30, P123, DOI [10.1155/2011/560572, 10.3233/DMA-2011-0768]
   O'Donovan A, 2010, BRAIN BEHAV IMMUN, V24, P1074, DOI 10.1016/j.bbi.2010.03.003
   Ohayon MM, 2003, ARCH GEN PSYCHIAT, V60, P39, DOI 10.1001/archpsyc.60.1.39
   ORVASCHEL H, 1995, J AM ACAD CHILD PSY, V34, P1525, DOI 10.1097/00004583-199511000-00020
   Pace TWW, 2007, BRAIN BEHAV IMMUN, V21, P9, DOI 10.1016/j.bbi.2006.08.009
   Pace TWW, 2006, AM J PSYCHIAT, V163, P1630, DOI 10.1176/appi.ajp.163.9.1630
   Pace TWW, 2011, BRAIN BEHAV IMMUN, V25, P6, DOI 10.1016/j.bbi.2010.10.003
   Pace TWW, 2012, BRAIN BEHAV IMMUN, V26, P13, DOI 10.1016/j.bbi.2011.07.232
   Pace TWW, 2011, BRAIN BEHAV IMMUN, V25, P1716, DOI 10.1016/j.bbi.2011.07.227
   Pace TWW, 2009, ANN NY ACAD SCI, V1179, P86, DOI 10.1111/j.1749-6632.2009.04984.x
   Pace TWW, 2009, PSYCHONEUROENDOCRINO, V34, P87, DOI 10.1016/j.psyneuen.2008.08.011
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pascual-Leone A, 2005, ANNU REV NEUROSCI, V28, P377, DOI 10.1146/annurev.neuro.27.070203.144216
   Pavlov VA, 2004, CELL MOL LIFE SCI, V61, P2322, DOI 10.1007/s00018-004-4102-3
   Pavlov VA, 2003, MOL MED, V9, P125, DOI 10.1007/BF03402177
   Paykel ES, 2003, ACTA PSYCHIAT SCAND, V108, P61, DOI 10.1034/j.1600-0447.108.s418.13.x
   Pecchi E, 2009, PHYSIOL BEHAV, V97, P279, DOI 10.1016/j.physbeh.2009.02.040
   Pedersen AF, 2009, BRAIN BEHAV IMMUN, V23, P427, DOI 10.1016/j.bbi.2009.01.004
   Perry VH, 2007, NAT REV IMMUNOL, V7, P161, DOI 10.1038/nri2015
   Persoons P, 2005, ALIMENT PHARM THER, V22, P101, DOI 10.1111/j.1365-2036.2005.02535.x
   Petersen KL, 2008, PSYCHOSOM MED, V70, P646, DOI 10.1097/PSY.0b013e31817b8ee4
   Phillips AC, 2009, J PSYCHOSOM RES, V67, P37, DOI 10.1016/j.jpsychores.2008.12.002
   Pike JL, 2006, BRAIN BEHAV IMMUN, V20, P169, DOI 10.1016/j.bbi.2005.05.004
   Pilkington K, 2005, J AFFECT DISORDERS, V89, P13, DOI 10.1016/j.jad.2005.08.013
   Pollitt RA, 2007, EUR J EPIDEMIOL, V22, P55, DOI 10.1007/s10654-006-9082-1
   Poole H, 2009, PAIN PRACT, V9, P173, DOI 10.1111/j.1533-2500.2009.00274.x
   Poon DCH, 2013, NEUROSCI BIOBEHAV R, V37, P1, DOI 10.1016/j.neubiorev.2012.11.001
   POST RM, 1992, AM J PSYCHIAT, V149, P999
   Post RM, 2007, NEUROSCI BIOBEHAV R, V31, P858, DOI 10.1016/j.neubiorev.2007.04.003
   Powell ND, 2013, P NATL ACAD SCI USA, V110, P16574, DOI 10.1073/pnas.1310655110
   Powell ND, 2011, IMMUNOL ALLERGY CLIN, V31, P69, DOI 10.1016/j.iac.2010.09.002
   Prather AA, 2009, BRAIN BEHAV IMMUN, V23, P622, DOI 10.1016/j.bbi.2008.11.004
   Quan N, 2007, BRAIN BEHAV IMMUN, V21, P727, DOI 10.1016/j.bbi.2007.05.005
   Radtke F, 2013, NAT REV IMMUNOL, V13, P427, DOI 10.1038/nri3445
   Raedler TJ, 2011, CURR OPIN PSYCHIATR, V24, P519, DOI 10.1097/YCO.0b013e32834b9db6
   Raetz CRH, 2002, ANNU REV BIOCHEM, V71, P635, DOI 10.1146/annurev.biochem.71.110601.135414
   Raison CL, 2013, MOL PSYCHIATR, V18, P15, DOI 10.1038/mp.2012.2
   Raison CL, 2010, MOL PSYCHIATR, V15, P393, DOI 10.1038/mp.2009.116
   Raison CL, 2013, JAMA PSYCHIAT, V70, P31, DOI 10.1001/2013.jamapsychiatry.4
   Raison CL, 2011, CURR PSYCHIAT REP, V13, P467, DOI 10.1007/s11920-011-0232-0
   Raison CL, 2006, TRENDS IMMUNOL, V27, P24, DOI 10.1016/j.it.2005.11.006
   REGIER DA, 1988, ARCH GEN PSYCHIAT, V45, P977
   Reiche EMV, 2004, LANCET ONCOL, V5, P617, DOI 10.1016/S1470-2045(04)01597-9
   Reichenberg A, 2001, ARCH GEN PSYCHIAT, V58, P445, DOI 10.1001/archpsyc.58.5.445
   Ren K, 2010, NAT MED, V16, P1267, DOI 10.1038/nm.2234
   Repetti RL, 2002, PSYCHOL BULL, V128, P330, DOI 10.1037/0033-2909.128.2.330
   Rhen T, 2005, NEW ENGL J MED, V353, P1711, DOI 10.1056/NEJMra050541
   Ricciotti E, 2011, ARTERIOSCL THROM VAS, V31, P986, DOI 10.1161/ATVBAHA.110.207449
   Ridker PM, 1997, NEW ENGL J MED, V336, P973, DOI 10.1056/NEJM199704033361401
   Rivest S, 2009, NAT REV IMMUNOL, V9, P429, DOI 10.1038/nri2565
   Robaeys G, 2007, WORLD J GASTROENTERO, V13, P5736, DOI 10.3748/wjg.v13.i43.5736
   Robinson GE, 2005, NAT REV GENET, V6, P257, DOI 10.1038/nrg1575
   Rohleder N, 2001, PSYCHOSOM MED, V63, P966, DOI 10.1097/00006842-200111000-00016
   Rook GAW, 2012, DRUG DISCOV TODAY, V17, P451, DOI 10.1016/j.drudis.2012.03.018
   Roose SP, 2005, J CLIN PSYCHOPHARM, V25, pS1, DOI 10.1097/01.jcp.0000162807.84570.6b
   Rosenberger PH, 2009, J BONE JOINT SURG AM, V91A, P2783, DOI 10.2106/JBJS.H.00989
   Rudolph KD, 2007, DEV PSYCHOPATHOL, V19, P497, DOI 10.1017/S0954579407070241
   Rueggeberg R, 2012, PSYCHOSOM MED, V74, P937, DOI 10.1097/PSY.0b013e3182732dc6
   Samad TA, 2001, NATURE, V410, P471, DOI 10.1038/35068566
   Sandkühler J, 2009, PHYSIOL REV, V89, P707, DOI 10.1152/physrev.00025.2008
   Sanislow CA, 2010, J ABNORM PSYCHOL, V119, P631, DOI 10.1037/a0020909
   SAPOLSKY R, 1987, SCIENCE, V238, P522, DOI 10.1126/science.2821621
   Savitz JB, 2009, NEUROSCIENCE, V164, P300, DOI 10.1016/j.neuroscience.2009.03.082
   Schiepers OJG, 2005, PROG NEURO-PSYCHOPH, V29, P201, DOI 10.1016/j.pnpbp.2004.11.003
   Schleifer SJ, 1999, PSYCHIAT RES, V85, P63, DOI 10.1016/S0165-1781(98)00133-4
   SCHLEIMER RP, 1993, EUR J CLIN PHARMACOL, V45, pS3, DOI 10.1007/BF01844196
   Schrepf A, 2013, BRAIN BEHAV IMMUN, V30, pS126, DOI 10.1016/j.bbi.2012.07.022
   Schultze-Florey CR, 2012, BRAIN BEHAV IMMUN, V26, P1066, DOI 10.1016/j.bbi.2012.06.009
   Schwarcz R, 2012, NAT REV NEUROSCI, V13, P465, DOI 10.1038/nrn3257
   Segerstrom SC, 2004, PSYCHOL BULL, V130, P601, DOI 10.1037/0033-2909.130.4.601
   Sengupta P, 2012, INT J PREVENTIVE MED, V3, P444
   Shelton RC, 2010, PROG NEUROBIOL, V91, P275, DOI 10.1016/j.pneurobio.2010.04.004
   SHROUT PE, 1989, J ABNORM PSYCHOL, V98, P460, DOI 10.1037/0021-843X.98.4.460
   Slavich G.M., 2010, The Stress and Adversity Inventory (STRAIN): An automated system for assessing cumulative stress exposure
   Slavich GM, 2013, CLIN PSYCHOL SCI, V1, P331, DOI 10.1177/2167702613478594
   Slavich GM, 2011, J PSYCHIATR RES, V45, P1146, DOI 10.1016/j.jpsychires.2011.03.004
   Slavich GM, 2010, P NATL ACAD SCI USA, V107, P14817, DOI 10.1073/pnas.1009164107
   Slavich GM, 2010, NEUROSCI BIOBEHAV R, V35, P39, DOI 10.1016/j.neubiorev.2010.01.003
   Slavich GM, 2009, J SOC CLIN PSYCHOL, V28, P223, DOI 10.1521/jscp.2009.28.2.223
   Sloman L., 2000, SUBORDINATION DEFEAT, DOI 10.4324/9781410605207
   Slopen N, 2013, PSYCHONEUROENDOCRINO, V38, P188, DOI 10.1016/j.psyneuen.2012.05.013
   Slopen N, 2010, PSYCHOSOM MED, V72, P694, DOI 10.1097/PSY.0b013e3181e9c16f
   Sluzewska A, 1995, ANN NY ACAD SCI, V762, P474
   Smith AK, 2012, MOL PSYCHIATR, V17, P781, DOI 10.1038/mp.2011.67
   SMITH CW, 1989, J CLIN INVEST, V83, P2008, DOI 10.1172/JCI114111
   SMITH RS, 1991, MED HYPOTHESES, V35, P298, DOI 10.1016/0306-9877(91)90272-Z
   Solomon DA, 2000, AM J PSYCHIAT, V157, P229, DOI 10.1176/appi.ajp.157.2.229
   Sommer C, 2004, NEUROSCI LETT, V361, P184, DOI 10.1016/j.neulet.2003.12.007
   Starr LR, 2012, COGNITIVE THER RES, V36, P321, DOI 10.1007/s10608-011-9363-1
   Starr LR, 2012, BEHAV RES THER, V50, P131, DOI 10.1016/j.brat.2011.11.005
   Steptoe A, 2007, BRAIN BEHAV IMMUN, V21, P901, DOI 10.1016/j.bbi.2007.03.011
   Steptoe A, 2012, NAT REV CARDIOL, V9, P360, DOI 10.1038/nrcardio.2012.45
   Sternberg EM, 2006, NAT REV IMMUNOL, V6, P318, DOI 10.1038/nri1810
   Stewart JC, 2009, BRAIN BEHAV IMMUN, V23, P936, DOI 10.1016/j.bbi.2009.04.011
   Strike PC, 2004, J PSYCHOSOM RES, V57, P189, DOI 10.1016/S0022-3999(03)00569-5
   Takeda K, 2003, ANNU REV IMMUNOL, V21, P335, DOI 10.1146/annurev.immunol.21.120601.141126
   Taylor SE, 2007, ANNU REV CLIN PSYCHO, V3, P377, DOI 10.1146/annurev.clinpsy.3.022806.091520
   Taylor SE, 2006, BIOL PSYCHIAT, V60, P819, DOI 10.1016/j.biopsych.2006.03.016
   Taylor SE, 2011, DEV PSYCHOPATHOL, V23, P939, DOI 10.1017/S0954579411000411
   Taylor SE, 2010, P NATL ACAD SCI USA, V107, P8507, DOI 10.1073/pnas.1003890107
   Taylor SE, 2010, J PERS SOC PSYCHOL, V98, P47, DOI 10.1037/a0016563
   Tracey KJ, 2009, NAT REV IMMUNOL, V9, P418, DOI 10.1038/nri2566
   Tung J, 2012, P NATL ACAD SCI USA, V109, P6490, DOI 10.1073/pnas.1202734109
   Tyring S, 2006, LANCET, V367, P29, DOI 10.1016/S0140-6736(05)67763-X
   Uher R, 2010, MOL PSYCHIATR, V15, P18, DOI 10.1038/mp.2009.123
   van den Biggelaar AHJ, 2007, EXP GERONTOL, V42, P693, DOI 10.1016/j.exger.2007.01.011
   van Donkelaar EL, 2011, MOL PSYCHIATR, V16, P695, DOI 10.1038/mp.2011.9
   Vialou V, 2013, ANNU REV PHARMACOL, V53, P59, DOI 10.1146/annurev-pharmtox-010611-134540
   Vos T, 2004, ARCH GEN PSYCHIAT, V61, P1097, DOI 10.1001/archpsyc.61.11.1097
   Waldburger Jean-Marc, 2010, Curr Rheumatol Rep, V12, P370, DOI 10.1007/s11926-010-0124-z
   Walker JG, 1999, RHEUMATOLOGY, V38, P1050, DOI 10.1093/rheumatology/38.11.1050
   Warner V, 1999, J AM ACAD CHILD PSY, V38, P289, DOI 10.1097/00004583-199903000-00016
   Warner-Schmidt JL, 2011, P NATL ACAD SCI USA, V108, P9262, DOI 10.1073/pnas.1104836108
   Watkins LR, 2000, ANNU REV PSYCHOL, V51, P29, DOI 10.1146/annurev.psych.51.1.29
   WATKINS LR, 1995, LIFE SCI, V57, P1011, DOI 10.1016/0024-3205(95)02047-M
   Watkins LR, 1999, P NATL ACAD SCI USA, V96, P7710, DOI 10.1073/pnas.96.14.7710
   Watson D, 2005, J ABNORM PSYCHOL, V114, P522, DOI 10.1037/0021-843X.114.4.522
   Way BM, 2010, PSYCHOSOM MED, V72, P107, DOI 10.1097/PSY.0b013e3181ce6a7d
   Webster Kimberly, 2003, Health Qual Life Outcomes, V1, P79, DOI 10.1186/1477-7525-1-79
   Weinstein AA, 2010, BIOL PSYCHOL, V84, P228, DOI 10.1016/j.biopsycho.2010.01.016
   WEISSMAN MM, 1995, SCIENCE, V269, P799, DOI 10.1126/science.7638596
   Whooley MA, 2006, JAMA-J AM MED ASSOC, V295, P2874, DOI 10.1001/jama.295.24.2874
   Wichers M, 2002, INT J NEUROPSYCHOPH, V5, P375, DOI 10.1017/S1461145702003103
   Wittchen HU, 2003, EUR PSYCHIAT, V18, P384, DOI 10.1016/j.eurpsy.2003.10.001
   Wittchen HU, 2000, ACTA PSYCHIAT SCAND, V102, P14, DOI 10.1111/j.0065-1591.2000.acp29[dash]03.x
   Wium-Andersen MK, 2013, JAMA PSYCHIAT, V70, P176, DOI 10.1001/2013.jamapsychiatry.102
   Wolkowitz OM, 2010, DEPRESS ANXIETY, V27, P327, DOI 10.1002/da.20686
   Wright CE, 2005, BRAIN BEHAV IMMUN, V19, P345, DOI 10.1016/j.bbi.2004.10.003
   Wright RJ, 2011, IMMUNOL ALLERGY CLIN, V31, P19, DOI 10.1016/j.iac.2010.09.011
   Wulsin LR, 2003, PSYCHOSOM MED, V65, P201, DOI 10.1097/01.PSY.0000058371.50240.E3
   Yaffe K, 2004, JAMA-J AM MED ASSOC, V292, P2237, DOI 10.1001/jama.292.18.2237
   Yamakawa K, 2009, BIOL PSYCHOL, V82, P25, DOI 10.1016/j.biopsycho.2009.05.001
   Yiend J, 2009, J AFFECT DISORDERS, V118, P79, DOI 10.1016/j.jad.2009.01.026
   Yirmiya R, 1996, BRAIN RES, V711, P163, DOI 10.1016/0006-8993(95)01415-2
   Yirmiya R, 2000, ANN NY ACAD SCI, V917, P478
   Yirmiya R, 1999, ADV EXP MED BIOL, V461, P283
   Yirmiya R, 2011, BRAIN BEHAV IMMUN, V25, P181, DOI 10.1016/j.bbi.2010.10.015
   Zhang TY, 2006, BIOL PSYCHOL, V73, P72, DOI 10.1016/j.biopsycho.2006.01.009
   Zorrilla EP, 2001, BRAIN BEHAV IMMUN, V15, P199, DOI 10.1006/brbi.2000.0597
NR 489
TC 1427
Z9 1630
U1 34
U2 675
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0033-2909
EI 1939-1455
J9 PSYCHOL BULL
JI Psychol. Bull.
PD MAY
PY 2014
VL 140
IS 3
BP 774
EP 815
DI 10.1037/a0035302
PG 42
WC Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA AG2CZ
UT WOS:000335224800007
PM 24417575
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Manczak, EM
   Gotlib, IH
AF Manczak, Erika M.
   Gotlib, Ian H.
TI Lipid Profiles at Birth Predict Teacher-Rated Child Emotional and Social
   Development 5 Years Later
SO PSYCHOLOGICAL SCIENCE
LA English
DT Article
DE fetal development; cholesterol; triglycerides; emotion regulation;
   psychological health
ID DENSITY-LIPOPROTEIN CHOLESTEROL; METABOLIC SYNDROME; FETAL EXPOSURE;
   HEALTH; RISK; DEPRESSION; PREGNANCY; DISEASE; COHORT; LEVEL
AB The fetal environment has been increasingly implicated in later psychological health, but the role of lipids is unknown. Drawing on the ethnically diverse Born in Bradford (BiB) birth cohort, the current study related levels of high-density lipoprotein (HDL), very-low-density lipoprotein (VLDL), and triglycerides in umbilical cord blood to 1,369 children's teacher-rated psychosocial competence approximately 5 years later. Results of ordinal logistic regressions indicated that low levels of HDL, high levels of VLDL, and high levels of triglycerides predicted greater likelihood of being rated as less competent in domains of emotion regulation, self-awareness, and interpersonal functioning. Furthermore, these results generalized across ethnic background and children's sex and were not accounted for by variables reflecting mothers' psychological or physical health, children's physical health, or children's special education status. Together, these results identify fetal exposure to anomalous lipid levels as a possible contributor to subsequent psychological health and social functioning.
C1 [Manczak, Erika M.] Univ Denver, Dept Psychol, 2155 S Race St, Denver, CO 80202 USA.
   [Gotlib, Ian H.] Stanford Univ, Dept Psychol, Stanford, CA 94305 USA.
C3 University of Denver; Stanford University
RP Manczak, EM (corresponding author), Univ Denver, Dept Psychol, 2155 S Race St, Denver, CO 80202 USA.
EM erika.manczak@du.edu
FU National Institute of Mental Health [R37-MH101495, MH019938]; Wellcome
   Trust [101597/Z/13/Z]; Wellcome Trust [101597/Z/13/Z] Funding Source:
   Wellcome Trust
FX This research was supported by National Institute of Mental Health
   Grants R37-MH101495 (to I. H. Gotlib) and MH019938 (funding E. M.
   Manczak). Born in Bradford receives biomedical resources infrastructure
   funding from the Wellcome Trust (101597/Z/13/Z).
CR Anantharamaiah GM, 2007, J LIPID RES, V48, P1915, DOI 10.1194/jlr.R700010-JLR200
   [Anonymous], 2012, Statutory framework for the Early Years Foundation Stage
   Baek JH, 2014, PROG NEURO-PSYCHOPH, V51, P113, DOI 10.1016/j.pnpbp.2014.01.018
   Bryant M, 2013, LONGITUD LIFE COURSE, V4, P119
   DiFranza JR, 2004, PEDIATRICS, V113, P1007
   Durlak JA, 2009, J PEDIATR PSYCHOL, V34, P917, DOI 10.1093/jpepsy/jsp004
   Ellman LM, 2009, BIOL PSYCHIAT, V65, P1040, DOI 10.1016/j.biopsych.2008.12.015
   Emet M, 2015, PSYCHIAT RES, V225, P202, DOI 10.1016/j.psychres.2014.11.026
   Eriksen BMS, 2017, PSYCHIAT RES, V255, P1, DOI 10.1016/j.psychres.2017.05.010
   Floyd K, 2007, HUM COMMUN RES, V33, P119, DOI 10.1111/j.1468-2958.2007.00293.x
   Fraser R, 1999, HYPERTENSION, V33, P1364, DOI 10.1161/01.HYP.33.6.1364
   Goldberg DP, 1997, PSYCHOL MED, V27, P191, DOI 10.1017/S0033291796004242
   GOLDBERG DP, 1979, PSYCHOL MED, V9, P139, DOI 10.1017/S0033291700021644
   Hernández-Díaz S, 2000, NEW ENGL J MED, V343, P1608, DOI 10.1056/NEJM200011303432204
   Howland MA, 2016, PSYCHONEUROENDOCRINO, V67, P10, DOI 10.1016/j.psyneuen.2016.01.023
   Hu H, 2006, ENVIRON HEALTH PERSP, V114, P1730, DOI 10.1289/ehp.9067
   Huang TL, 2005, ADV CLIN CHEM, V39, P81, DOI 10.1016/S0065-2423(04)39003-7
   Igna CV, 2011, PSYCHIAT RES, V187, P363, DOI 10.1016/j.psychres.2010.10.016
   JOHNSON EH, 1992, J BEHAV MED, V15, P285, DOI 10.1007/BF00845357
   Kim SJ, 2018, J AFFECT DISORDERS, V225, P317, DOI 10.1016/j.jad.2017.08.016
   Maes M, 1997, ACTA PSYCHIAT SCAND, V95, P212, DOI 10.1111/j.1600-0447.1997.tb09622.x
   Mattson SN, 1997, J PEDIATR-US, V131, P718, DOI 10.1016/S0022-3476(97)70099-4
   Needham LL, 2011, ENVIRON SCI TECHNOL, V45, P1121, DOI 10.1021/es1019614
   Olson RE, 1998, J NUTR, V128, p439S, DOI 10.1093/jn/128.2.439S
   Pariante CM, 2017, PSYCHONEUROENDOCRINO, V83, P87, DOI 10.1016/j.psyneuen.2017.07.473
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Raynor P, 2008, BMC PUBLIC HEALTH, V8, DOI 10.1186/1471-2458-8-327
   Roaldset JO, 2011, PSYCHIAT RES, V186, P293, DOI 10.1016/j.psychres.2010.07.029
   Robinson M, 2008, J CHILD PSYCHOL PSYC, V49, P1118, DOI 10.1111/j.1469-7610.2008.01955.x
   Roh SJ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0108406
   Roza SJ, 2010, BRIT J NUTR, V103, P445, DOI 10.1017/S0007114509991954
   Sandman CA, 2013, J PSYCHOSOM RES, V75, P327, DOI 10.1016/j.jpsychores.2013.07.009
   Scanlon SM, 2001, BIOCHEMISTRY-US, V40, P10507, DOI 10.1021/bi010730z
   Shimizu T, 2009, ANNU REV PHARMACOL, V49, P123, DOI 10.1146/annurev.pharmtox.011008.145616
   Siever LJ, 2008, AM J PSYCHIAT, V165, P429, DOI 10.1176/appi.ajp.2008.07111774
   Sutin AR, 2010, BIOL PSYCHOL, V84, P186, DOI 10.1016/j.biopsycho.2010.01.012
   Tall AR, 2015, NAT REV IMMUNOL, V15, P104, DOI 10.1038/nri3793
   Todaro JF, 2003, AM J CARDIOL, V92, P901, DOI 10.1016/S0002-9149(03)00967-6
   Wright CM, 2002, ARCH DIS CHILD, V86, P11, DOI 10.1136/adc.86.1.11
   Wright J, 2013, INT J EPIDEMIOL, V42, P978, DOI 10.1093/ije/dys112
   Yates KF, 2012, ARTERIOSCL THROM VAS, V32, P2060, DOI 10.1161/ATVBAHA.112.252759
NR 41
TC 7
Z9 8
U1 2
U2 11
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0956-7976
EI 1467-9280
J9 PSYCHOL SCI
JI Psychol. Sci.
PD DEC
PY 2019
VL 30
IS 12
BP 1780
EP 1789
AR 0956797619885649
DI 10.1177/0956797619885649
EA NOV 2019
PG 10
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA JV1QN
UT WOS:000497077700001
PM 31710576
OA Green Published
DA 2025-06-11
ER

PT J
AU Human, LJ
   Biesanz, JC
   Miller, GE
   Chen, E
   Lachman, ME
   Seeman, TE
AF Human, Lauren J.
   Biesanz, Jeremy C.
   Miller, Gregory E.
   Chen, Edith
   Lachman, Margie E.
   Seeman, Teresa E.
TI Is hCange Bad? Personality Change Is Associated with Poorer
   Psychological Health and Greater Metabolic Syndrome in Midlife
SO JOURNAL OF PERSONALITY
LA English
DT Article
ID TRAITS; CHILDHOOD; RISK; PREDICTORS; MORTALITY; RESILIENCE; MECHANISMS;
   DEPRESSION; HOSTILITY; PATHWAYS
AB Personality change is emerging as an important predictor of health and well-being. Extending previous research, we examined whether two types of personality change, directional and absolute, are associated with both subjective and objective indicators of health. Utilizing the longitudinal Midlife in the United States survey (MIDUS) data, we examined whether both types of change over 10 years were associated with psychological well-being, self-reported global health, and the presence of metabolic syndrome (MetS) components and diagnosis. Socially undesirable personality change (e.g., becoming less conscientious and more neurotic) and absolute personality change were independently associated with worse perceived health and well-being at Time 2. Notably, absolute personality change, regardless of the direction, was also associated with having a greater number of MetS components and a greater probability of diagnosis at Time 2. In sum, too much personality change may be bad for one's health: Socially undesirable and absolute personality change were both associated with worse psychological health and worse metabolic profiles over 10 years. These findings suggest that personality change may contribute to psychological and physical health, and provide initial insight into potential intermediate links between personality change and distal outcomes such as mortality.
C1 [Human, Lauren J.; Biesanz, Jeremy C.] Univ British Columbia, Vancouver, BC V6T 1Z4, Canada.
   [Miller, Gregory E.; Chen, Edith] Northwestern Univ, Evanston, IL 60208 USA.
   [Lachman, Margie E.] Brandeis Univ, Waltham, MA 02254 USA.
   [Seeman, Teresa E.] Univ Calif Los Angeles, Los Angeles, CA USA.
C3 University of British Columbia; Northwestern University; Brandeis
   University; University of California System; University of California
   Los Angeles
RP Human, LJ (corresponding author), Univ British Columbia, Dept Psychol, 2136 West Mall, Vancouver, BC V6T 1Z4, Canada.
EM lhuman@psych.ubc.ca
OI Miller, Gregory/0000-0002-7217-1082; Lachman, Margie/0000-0003-3027-8735
CR ADLER N, 1994, ANNU REV PSYCHOL, V45, P229, DOI 10.1146/annurev.psych.45.1.229
   [Anonymous], 1957, SOCIAL DESIRABILITY
   Bogg T, 2004, PSYCHOL BULL, V130, P887, DOI 10.1037/0033-2909.130.6.887
   BRANDTSTADTER J, 1994, DEV REV, V14, P52, DOI 10.1006/drev.1994.1003
   Caspi A, 2005, ANNU REV PSYCHOL, V56, P453, DOI 10.1146/annurev.psych.55.090902.141913
   Dortland AKBV, 2012, PROG NEURO-PSYCHOPH, V36, P85, DOI 10.1016/j.pnpbp.2011.10.001
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Eizenman DR, 1997, PSYCHOL AGING, V12, P489, DOI 10.1037/0882-7974.12.3.489
   Elovainio M, 2011, BIOL PSYCHOL, V87, P234, DOI 10.1016/j.biopsycho.2011.03.002
   Friedman HS, 2000, J PERS, V68, P1089, DOI 10.1111/1467-6494.00127
   Gelman A, 2008, STAT MED, V27, P2865, DOI 10.1002/sim.3107
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Graham E. K., 2012, J GERONTOLOGY B, DOI 10.1093/geronb/gbr149
   Hampson SE, 2007, HEALTH PSYCHOL, V26, P121, DOI 10.1037/0278-6133.26.1.121
   Hill P. L., 2012, SOCIAL PSYCHOL PERSO, DOI 10.1177/1948550611433888
   JOHN OP, 1993, J PERS, V61, P521, DOI 10.1111/j.1467-6494.1993.tb00781.x
   Kern ML, 2011, SOC PERSONAL PSYCHOL, V5, P76, DOI 10.1111/j.1751-9004.2010.00331.x
   Korten AE, 1999, J EPIDEMIOL COMMUN H, V53, P83, DOI 10.1136/jech.53.2.83
   Lachman ME, 1997, The Midlife Development Inventory (MIDI) Personality Scales: Scale Construction and Scoring
   Love GD, 2010, J AGING HEALTH, V22, P1059, DOI 10.1177/0898264310374355
   Miller G, 2009, ANNU REV PSYCHOL, V60, P501, DOI 10.1146/annurev.psych.60.110707.163551
   Miller GE, 2011, PSYCHOL SCI, V22, P1591, DOI 10.1177/0956797611419170
   Mroczek DK, 2007, PSYCHOL SCI, V18, P371, DOI 10.1111/j.1467-9280.2007.01907.x
   Mroczek DK, 2009, J RES PERS, V43, P653, DOI 10.1016/j.jrp.2009.03.016
   Phillips AC, 2010, J PSYCHOSOM RES, V69, P193, DOI 10.1016/j.jpsychores.2010.01.016
   Prenda KM, 2001, PSYCHOL AGING, V16, P206, DOI 10.1037//0882-7974.16.2.206
   Puustinen PJ, 2011, PSYCHOSOM MED, V73, P158, DOI 10.1097/PSY.0b013e3182037315
   Roberts BW, 2007, PERSPECT PSYCHOL SCI, V2, P313, DOI 10.1111/j.1745-6916.2007.00047.x
   Roberts BW, 2008, CURR DIR PSYCHOL SCI, V17, P31, DOI 10.1111/j.1467-8721.2008.00543.x
   Roberts BW, 2000, PSYCHOL BULL, V126, P3, DOI 10.1037/0033-2909.126.1.3
   ROGOSA DR, 1983, J EDUC MEAS, V20, P335, DOI 10.1111/j.1745-3984.1983.tb00211.x
   RYFF CD, 1995, J PERS SOC PSYCHOL, V69, P719
   Sherman RA, 2012, J RES PERS, V46, P87, DOI 10.1016/j.jrp.2011.12.006
   Siegler IC, 2003, PSYCHOSOM MED, V65, P738, DOI 10.1097/01.PSY.0000088583.25140.9C
   Smith TW, 2006, CURR DIR PSYCHOL SCI, V15, P227, DOI 10.1111/j.1467-8721.2006.00441.x
   Sutin AR, 2010, AGE, V32, P513, DOI 10.1007/s11357-010-9153-9
   Taga KA, 2009, J PERS, V77, P669, DOI 10.1111/j.1467-6494.2009.00561.x
   Turiano NA, 2012, J GERONTOL B-PSYCHOL, V67, P4, DOI 10.1093/geronb/gbr072
   Vollrath M, 1999, EUR J PERSONALITY, V13, P39, DOI 10.1002/(SICI)1099-0984(199901/02)13:1<39::AID-PER328>3.0.CO;2-J
   Wiggins J.S., 1991, THINKING CLEARLY PSY, V2, P89
   Zimprich D., 2011, PSYCHOL ASSESSMENT, DOI 10.1037/a0025265
NR 41
TC 58
Z9 63
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3506
EI 1467-6494
J9 J PERS
JI J. Pers.
PD JUN
PY 2013
VL 81
IS 3
BP 249
EP 260
DI 10.1111/jopy.12002
PG 12
WC Psychology, Social
WE Social Science Citation Index (SSCI)
SC Psychology
GA 144OU
UT WOS:000318950100002
PM 22924900
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Poursafa, P
   Kamali, Z
   Fraszczyk, E
   Boezen, HM
   Vaez, A
   Snieder, H
AF Poursafa, Parinaz
   Kamali, Zoha
   Fraszczyk, Eliza
   Boezen, H. Marike
   Vaez, Ahmad
   Snieder, Harold
TI DNA methylation: a potential mediator between air pollution and
   metabolic syndrome
SO CLINICAL EPIGENETICS
LA English
DT Review
DE Epigenetics; DNA methylation; Metabolic syndrome; Air pollution
ID POLYCYCLIC AROMATIC-HYDROCARBONS; EPIGENOME-WIDE ASSOCIATION; FINE
   PARTICULATE MATTER; CARDIOMETABOLIC RISK-FACTORS; GENE-SPECIFIC
   METHYLATION; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION;
   ENVIRONMENTAL-FACTORS; PROMOTER METHYLATION; INSULIN-RESISTANCE
AB Given the global increase in air pollution and its crucial role in human health, as well as the steep rise in prevalence of metabolic syndrome (MetS), a better understanding of the underlying mechanisms by which environmental pollution may influence MetS is imperative. Exposure to air pollution is known to impact DNA methylation, which in turn may affect human health. This paper comprehensively reviews the evidence for the hypothesis that the effect of air pollution on the MetS is mediated by DNA methylation in blood. First, we present a summary of the impact of air pollution on metabolic dysregulation, including the components of MetS, i.e., disorders in blood glucose, lipid profile, blood pressure, and obesity. Then, we provide evidence on the relation between air pollution and endothelial dysfunction as one possible mechanism underlying the relation between air pollution and MetS. Subsequently, we review the evidence that air pollution (PM, ozone, NO2 and PAHs) influences DNA methylation. Finally, we summarize association studies between DNA methylation and MetS. Integration of current evidence supports our hypothesis that methylation may partly mediate the effect of air pollution on MetS.
C1 [Poursafa, Parinaz; Kamali, Zoha; Fraszczyk, Eliza; Boezen, H. Marike; Vaez, Ahmad; Snieder, Harold] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
   [Kamali, Zoha; Vaez, Ahmad] Isfahan Univ Med Sci, Dept Bioinformat, Esfahan, Iran.
C3 University of Groningen; Isfahan University of Medical Sciences
RP Vaez, A; Snieder, H (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
EM a.vaez@umcg.nl; h.snieder@umcg.nl
RI Vaez, Ahmad/B-4336-2018; poursafa, parinaz/U-2924-2017; Fraszczyk,
   Eliza/GQO-9951-2022
OI Fraszczyk, Eliza/0000-0002-2163-1560; Kamali, Zoha/0000-0001-6492-5887
FU Isfahan University of Medical Sciences, Isfahan, Iran
FX ZK and AV are financially supported by Isfahan University of Medical
   Sciences, Isfahan, Iran.
CR Abraham E, 2018, ENVIRON INT, V118, P334, DOI 10.1016/j.envint.2018.05.007
   Akinyemiju T, 2018, CLIN EPIGENETICS, V10, DOI 10.1186/s13148-018-0483-2
   Alegría-Torres JA, 2013, CHEMOSPHERE, V91, P475, DOI 10.1016/j.chemosphere.2012.11.077
   Ali O, 2016, EPIGENETICS-US, V11, P699, DOI 10.1080/15592294.2016.1216284
   Alvarado-Cruz I, 2018, ANN GLOB HEALTH, V84, P212, DOI 10.29024/aogh.909
   Alvarado-Cruz I, 2017, MUTAT RES-GEN TOX EN, V813, P27, DOI 10.1016/j.mrgentox.2016.11.007
   [Anonymous], HOUSEHOLD AIR POLLUT
   [Anonymous], THINGS YOU CAN HELP
   [Anonymous], R01 US EPA
   Baccarelli A, 2010, EPIDEMIOLOGY, V21, P819, DOI 10.1097/EDE.0b013e3181f20457
   Bansal A, 2017, PEDIATR DIABETES, V18, P167, DOI 10.1111/pedi.12521
   Battram T, 2021, PREPRINT
   Bell JT, 2011, TRENDS GENET, V27, P116, DOI 10.1016/j.tig.2010.12.005
   Bellavia A, 2013, J AM HEART ASSOC, V2, DOI 10.1161/JAHA.113.000212
   Bibikova M, 2009, EPIGENOMICS-UK, V1, P177, DOI 10.2217/EPI.09.14
   Bind MA, 2014, EPIGENETICS-US, V9, P448, DOI 10.4161/epi.27584
   Bind MA, 2012, EPIDEMIOLOGY, V23, P332, DOI 10.1097/EDE.0b013e31824523f0
   Bind MAC, 2015, ENVIRON HEALTH PERSP, V123, P759, DOI 10.1289/ehp.1307824
   Bourdrel T, 2017, ARCH CARDIOVASC DIS, V110, P634, DOI 10.1016/j.acvd.2017.05.003
   Bowe B, 2018, LANCET PLANET HEALTH, V2, pE301, DOI 10.1016/s2542-5196(18)30140-2
   Brambilla P, 2007, INT J OBESITY, V31, P591, DOI 10.1038/sj.ijo.0803581
   Breton CV, 2016, ENVIRON HEALTH PERSP, V124, P1905, DOI 10.1289/EHP181
   Brook RD, 2016, HYPERTENSION, V67, P77, DOI 10.1161/HYPERTENSIONAHA.115.06237
   Buitrago D, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-23142-8
   Campagna MP, 2021, CLIN EPIGENETICS, V13, DOI 10.1186/s13148-021-01200-8
   Cantone L, 2017, ENVIRON RES, V152, P478, DOI 10.1016/j.envres.2016.11.002
   Carson C, 2018, PHYSIOL GENOMICS, V50, P947, DOI 10.1152/physiolgenomics.00072.2018
   Chen RJ, 2016, ENVIRON INT, V94, P614, DOI 10.1016/j.envint.2016.06.026
   Chen RJ, 2015, ENVIRON SCI TECHNOL, V49, P11859, DOI 10.1021/acs.est.5b02527
   Chi GC, 2016, ENVIRON HEALTH PERSP, V124, P1840, DOI 10.1289/EHP199
   Chi GC, 2016, ENVIRON HEALTH-GLOB, V15, DOI 10.1186/s12940-016-0202-4
   Clay K., 2019, RECENT INCREASES AIR, DOI 10.3386/w26381
   Clementi EA, 2019, TOXICS, V7, DOI 10.3390/toxics7010006
   Cohen AJ, 2017, LANCET, V389, P1907, DOI [10.1016/s0140-6736(17)30505-6, 10.1016/S0140-6736(17)30505-6]
   Cook S, 2008, J PEDIATR, V152, P165, DOI 10.1016/j.jpeds.2007.06.004
   Cookson W, 2009, NAT REV GENET, V10, P184, DOI 10.1038/nrg2537
   Dai LZ, 2017, EPIGENETICS-US, V12, P139, DOI 10.1080/15592294.2016.1271853
   Das M, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0145789
   de Ferranti SD, 2004, CIRCULATION, V110, P2494, DOI 10.1161/01.CIR.0000145117.40114.C7
   De Prins S, 2013, ENVIRON INT, V59, P418, DOI 10.1016/j.envint.2013.07.007
   Demerath EW, 2015, HUM MOL GENET, V24, P4464, DOI 10.1093/hmg/ddv161
   Ding R, 2017, SCI REP-UK, V7, DOI 10.1038/srep43737
   Dubey RK, 2002, CARDIOVASC RES, V53, P688, DOI 10.1016/S0008-6363(01)00527-2
   Epigenetics, 2022, WIKIPEDIA
   European Commission. Directorate General for the Environment. University of the West of England (UWE). Science Communication Unit, 2016, LINKS NOISE AIR POLL, DOI [10.2779/200217, DOI 10.2779/200217]
   Eze IC, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0130337
   Felix JF, 2018, INT J EPIDEMIOL, V47, P22, DOI 10.1093/ije/dyx190
   Ferrari L, 2019, CLIN EPIGENETICS, V11, DOI 10.1186/s13148-019-0726-x
   Fiorito G, 2018, ENVIRON MOL MUTAGEN, V59, P234, DOI 10.1002/em.22153
   Gluckman PD, 2008, INT J OBESITY, V32, pS62, DOI 10.1038/ijo.2008.240
   Godfrey KM, 2011, DIABETES, V60, P1528, DOI 10.2337/db10-0979
   Goldberg AD, 2007, CELL, V128, P635, DOI 10.1016/j.cell.2007.02.006
   Gondalia R, 2019, ENVIRON INT, V132, DOI 10.1016/j.envint.2019.03.071
   Gruzieva O, 2017, ENVIRON HEALTH PERSP, V125, P104, DOI 10.1289/EHP36
   Hahad O, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21124306
   Hajat Anjum, 2015, Curr Environ Health Rep, V2, P440, DOI 10.1007/s40572-015-0069-5
   Hall E.S., 2014, AM J ENV ENG, V4, P147, DOI DOI 10.5923/J.AJEE.20140406.02
   Herbstman JB, 2012, ENVIRON HEALTH PERSP, V120, P733, DOI 10.1289/ehp.1104056
   Hidalgo B, 2014, DIABETES, V63, P801, DOI 10.2337/db13-1100
   Hou LF, 2012, INT J EPIDEMIOL, V41, P79, DOI 10.1093/ije/dyr154
   Huang W, 2018, AM J HYPERTENS, V31, P590, DOI 10.1093/ajh/hpx216
   Huang YS, 2020, HYPERTENSION, V76, P195, DOI 10.1161/HYPERTENSIONAHA.120.14973
   HUGHES GS, 1989, J HYPERTENS, V7, P181
   IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2016, IARC Monogr Eval Carcinog Risks Hum, V109, P9
   Jiang S, 2016, INT ARCH OCC ENV HEA, V89, P911, DOI 10.1007/s00420-016-1129-3
   Jiang YX, 2019, ENVIRON RES, V177, DOI 10.1016/j.envres.2019.108620
   Jiao KS, 2018, INT J EQUITY HEALTH, V17, DOI 10.1186/s12939-018-0719-y
   Kapiotis S, 2006, ARTERIOSCL THROM VAS, V26, P2541, DOI 10.1161/01.ATV.0000245795.08139.70
   Kelishadi R, 2014, PAEDIATR INT CHILD H, V34, P165, DOI 10.1179/2046905513Y.0000000104
   Kelishadi R, 2009, ATHEROSCLEROSIS, V203, P311, DOI 10.1016/j.atherosclerosis.2008.06.022
   Kim YH, 2016, ENVIRON RES, V150, P47, DOI 10.1016/j.envres.2016.05.043
   Krall Jenna R, 2015, Curr Environ Health Rep, V2, P388, DOI 10.1007/s40572-015-0071-y
   Kresovich JK, 2017, BIOMARKERS, V22, P584, DOI 10.1080/1354750X.2017.1347961
   Kulkarni H, 2015, HUM MOL GENET, V24, P5330, DOI 10.1093/hmg/ddv232
   Küpers LK, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-09671-3
   Kupers LK, 2015, INT J EPIDEMIOL, V44, P1224, DOI 10.1093/ije/dyv048
   Latini G, 2004, ACTA PAEDIATR, V93, P1635, DOI 10.1080/08035250410023106
   Lee MK, 2019, CLIN EPIGENETICS, V11, DOI 10.1186/s13148-019-0635-z
   Li J, 2018, ENVIRON HEALTH PERSP, V126, DOI 10.1289/EHP2773
   Li SZ, 2019, CLIN EPIGENETICS, V11, DOI 10.1186/s13148-019-0659-4
   Liang MY, 2018, HYPERTENSION, V72, P1244, DOI 10.1161/HYPERTENSIONAHA.118.11171
   Lichtenfels AJDC, 2018, ENVIRON HEALTH PERSP, V126, DOI [10.1289/EHP2045, 10.1289/ehp2045]
   Lin SS, 2019, CLIN EPIGENETICS, V11, DOI 10.1186/s13148-019-0611-7
   Lopes LL, 2019, J AM COLL NUTR, V38, P478, DOI 10.1080/07315724.2018.1553116
   Flores-Viveros KL, 2019, OBES RES CLIN PRACT, V13, P533, DOI 10.1016/j.orcp.2019.10.012
   Luttmer R, 2013, OBES RES CLIN PRACT, V7, pE106, DOI 10.1016/j.orcp.2012.06.001
   Moran S, 2016, EPIGENOMICS-UK, V8, P389, DOI 10.2217/epi.15.114
   Mostafavi N, 2017, EPIDEMIOLOGY, V28, P320, DOI 10.1097/EDE.0000000000000628
   Newell-Price J, 2000, TRENDS ENDOCRIN MET, V11, P142, DOI 10.1016/S1043-2760(00)00248-4
   Ouidir M, 2020, CLIN EPIGENETICS, V12, DOI 10.1186/s13148-020-00894-6
   Panni T, 2016, ENVIRON HEALTH PERSP, V124, P983, DOI 10.1289/ehp.1509966
   Peng C, 2016, ENVIRON HEALTH PERSP, V124, P1715, DOI 10.1289/EHP183
   Plusquin M, 2018, ENVIRON SCI TECHNOL, V52, P5427, DOI 10.1021/acs.est.7b06447
   Pope CA, 2016, CIRC RES, V119, P1204, DOI 10.1161/CIRCRESAHA.116.309279
   Popovich Nadja., 2019, NEW YORK TIMES
   Poursafa P, 2018, ENVIRON INT, V118, P203, DOI 10.1016/j.envint.2018.05.048
   Poursafa P, 2016, ENVIRON RES, V146, P154, DOI 10.1016/j.envres.2015.12.018
   Poursafa P, 2014, ENVIRON RES, V134, P105, DOI 10.1016/j.envres.2014.07.010
   Poursafa P, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-115
   Raftopoulos L, 2015, LIFE SCI, V129, P22, DOI 10.1016/j.lfs.2014.08.003
   Ramzan F, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22095047
   Reckelhoff JF, 2019, MAYO CLIN PROC, V94, P536, DOI 10.1016/j.mayocp.2018.11.016
   Relton CL, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000356
   Richard MA, 2017, AM J HUM GENET, V101, P888, DOI 10.1016/j.ajhg.2017.09.028
   Rider CF, 2019, CLIN EPIGENETICS, V11, DOI 10.1186/s13148-019-0713-2
   Rossnerova A, 2013, MUTAT RES-FUND MOL M, V741, P18, DOI 10.1016/j.mrfmmm.2013.02.003
   Saenen ND, 2019, CLIN EPIGENETICS, V11, DOI 10.1186/s13148-019-0688-z
   Saenen ND, 2017, ENVIRON HEALTH PERSP, V125, P262, DOI 10.1289/EHP38
   Saffery R, 2014, ACTA OBSTET GYN SCAN, V93, P1090, DOI 10.1111/aogs.12431
   Salam MT, 2012, J ALLERGY CLIN IMMUN, V129, P232, DOI 10.1016/j.jaci.2011.09.037
   Sayols-Baixeras S, 2019, ENVIRON RES, V176, DOI 10.1016/j.envres.2019.108550
   Scinicariello F, 2014, ENVIRON HEALTH PERSP, V122, P299, DOI 10.1289/ehp.1307234
   Shaddick G, 2020, NPJ CLIM ATMOS SCI, V3, DOI 10.1038/s41612-020-0124-2
   Shi YF, 2019, SCI TOTAL ENVIRON, V650, P908, DOI 10.1016/j.scitotenv.2018.09.085
   Smith ZD, 2013, NAT REV GENET, V14, P204, DOI 10.1038/nrg3354
   Srogi K, 2007, ENVIRON CHEM LETT, V5, P169, DOI 10.1007/s10311-007-0095-0
   Stelzer Gil, 2016, Curr Protoc Bioinformatics, V54, DOI 10.1002/cpbi.5
   Suhaimi NF, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18157995
   Tantoh DM, 2020, CLIN EPIGENETICS, V12, DOI 10.1186/s13148-020-00908-3
   Tarantini L, 2013, OCCUP ENVIRON MED, V70, P418, DOI 10.1136/oemed-2012-101079
   Tong SL, 2019, LANCET PLANET HEALTH, V3, pE49, DOI 10.1016/S2542-5196(18)30288-2
   Van Cauwenbergh O, 2020, CLIN EPIGENETICS, V12, DOI 10.1186/s13148-020-00845-1
   van Vliet-Ostaptchouk Jana V, 2012, Curr Nutr Rep, V1, P184
   Visscher PM, 2017, AM J HUM GENET, V101, P5, DOI 10.1016/j.ajhg.2017.06.005
   Wadhwa PD, 2009, SEMIN REPROD MED, V27, P358, DOI 10.1055/s-0029-1237424
   Wahl S, 2017, NATURE, V541, P81, DOI 10.1038/nature20784
   Walaszczyk E, 2018, DIABETOLOGIA, V61, P354, DOI 10.1007/s00125-017-4497-7
   Wallwork RS, 2017, AM J EPIDEMIOL, V185, P30, DOI 10.1093/aje/kww157
   Wang XM, 2013, PLOS ONE, V8, DOI [10.1371/journal.pone.0055714, 10.1371/journal.pone.0053938, 10.1371/journal.pone.0050627]
   Wang XL, 2018, CLIN EPIGENETICS, V10, DOI 10.1186/s13148-017-0435-2
   Wei HY, 2016, SCI REP-UK, V6, DOI 10.1038/srep33402
   Wei YJ, 2016, FASEB J, V30, P2115, DOI 10.1096/fj.201500142
   Williams L, 2016, DIABETOLOGIA, V59, P1714, DOI 10.1007/s00125-016-3983-7
   World Health Organization, 2018, BURD DIS HOUS POLL 2
   Xia YJ, 2018, ENVIRON SCI TECHNOL, V52, P12774, DOI 10.1021/acs.est.8b03044
   Xita N, 2010, ANN NY ACAD SCI, V1205, P148, DOI 10.1111/j.1749-6632.2010.05658.x
   Xu MX, 2019, FREE RADICAL BIO MED, V130, P542, DOI 10.1016/j.freeradbiomed.2018.11.016
   Yara S, 2015, EPIGENOMICS-UK, V7, P283, DOI [10.2217/EPI.14.84, 10.2217/epi.14.84]
   Zakarya R, 2019, CLIN EPIGENETICS, V11, DOI 10.1186/s13148-019-0631-3
   Zheng YA, 2017, ENVIRON RES, V153, P112, DOI 10.1016/j.envres.2016.11.015
   Zou L, 2013, J DIABETES RES, V2013, DOI 10.1155/2013/721493
NR 141
TC 32
Z9 36
U1 6
U2 44
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1868-7075
EI 1868-7083
J9 CLIN EPIGENETICS
JI Clin. Epigenetics
PD DEC
PY 2022
VL 14
IS 1
AR 82
DI 10.1186/s13148-022-01301-y
PG 13
WC Oncology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Genetics & Heredity
GA 2O9YQ
UT WOS:000819407800001
PM 35773726
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jeon, SW
   Lim, SW
   Shin, DW
   Ryu, S
   Chang, Y
   Kim, SY
   Oh, KS
   Shin, YC
   Kim, YH
AF Jeon, Sang Won
   Lim, Se-Won
   Shin, Dong-Won
   Ryu, Seungho
   Chang, Yoosoo
   Kim, Sun-Young
   Oh, Kang-Seob
   Shin, Young-Chul
   Kim, Young Hwan
TI Metabolic syndrome and incident depressive symptoms in young and
   middle-aged adults: A cohort study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Depressive symptoms; Metabolic syndrome; Obesity; Cohort
   study
ID CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; DIABETES-MELLITUS;
   ASSOCIATION; RISK; ANXIETY; OBESITY; PREVALENCE; MANAGEMENT; MORTALITY
AB Background: : Recent studies on the prospective association between metabolic syndrome (MetS) and depression have reported conflicting findings.
   Methods: : A cohort study was performed with 115,223 middle-aged adults, free of depression at baseline, who underwent at least 2 comprehensive exams between 2012 and 2015. MetS was assessed according to the National Cholesterol Education Program Adult Treatment Panel III. The study endpoint was new onset of depression, defined as a Center for Epidemiologic Studies-Depression Scale score >= 16.
   Results: : Over 253,451.6 person-years, 6,833 participants developed depression. When the participants with 0 MetS components were set as a reference, the multivariable-adjusted hazard ratio (HR, 95% confidence interval [CI]) for incident depression formed a U-shaped curve with the number of MetS components (p for trend = 0.229): 1 (1.07 [1.02-1.15]); 2 (0.92 [0.82-1.06]); 3 (0.85 [0.78-1.07]); 4 (1.16 [1.06-1.32]); and 5 MetS components (1.25 [1.10-1.54]). The presence or absence of MetS was not significant in new-onset depression. In examining potential clustering and synergistic effects of the constituent parts, waist circumference was the major driving factor of incident depression, and its relative excess risk due to interaction increased with the number of combinations.
   Limitations: : We used a self-reported depression scale, and the follow-up period was relatively short.
   Conclusions: : Future studies investigating the risk for incident depression should place more focus on the number of MetS abnormalities and specific MetS factors, such as waist circumference, than the presence or absence of MetS.
C1 [Jeon, Sang Won; Lim, Se-Won; Shin, Dong-Won; Kim, Sun-Young; Oh, Kang-Seob; Shin, Young-Chul] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Psychiat, 29 Saemunan Ro, Seoul 03181, South Korea.
   [Lim, Se-Won; Shin, Young-Chul] Kangbuk Samsung Hosp, Workpl Mental Hlth Inst, Seoul, South Korea.
   [Ryu, Seungho; Chang, Yoosoo] Kangbuk Samsung Hosp, Total Healthcare Ctr, Ctr Cohort Study, Seoul, South Korea.
   [Ryu, Seungho; Chang, Yoosoo] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Occupat & Environm Med, Seoul, South Korea.
   [Kim, Young Hwan] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Nucl Med, Seoul, South Korea.
C3 Sungkyunkwan University (SKKU); Sungkyunkwan University (SKKU); Samsung
   Medical Center; Sungkyunkwan University (SKKU); Samsung Medical Center;
   Sungkyunkwan University (SKKU); Samsung Medical Center; Sungkyunkwan
   University (SKKU); Samsung Medical Center
RP Lim, SW; Shin, DW (corresponding author), Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Psychiat, 29 Saemunan Ro, Seoul 03181, South Korea.
EM healthysewon@daum.net; ntour@unitel.co.kr
RI Shin, Dong/F-5366-2010; Kim, Hyo Yeol/HLP-5150-2023
OI Kim, Young Hwan/0000-0002-6513-3846; Chang, Yoosoo/0000-0002-6945-9050;
   Ryu, Seungho/0000-0002-3927-8646
FU Korea Health Technology R&D Project through the Korea Health Industry
   Development Institute (KHIDI) - Ministry of Health & Welfare, Republic
   of Korea [HC15C1405]
FX This research was supported by a grant of the Korea Health Technology
   R&D Project through the Korea Health Industry Development Institute
   (KHIDI), funded by the Ministry of Health & Welfare, Republic of
   Korea(grant number: HC15C1405).
CR Akbaraly TN, 2011, DIABETES CARE, V34, P904, DOI 10.2337/dc10-1644
   Akbaraly TN, 2009, DIABETES CARE, V32, P499, DOI 10.2337/dc08-1358
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Almeida OP, 2009, AM J GERIAT PSYCHIAT, V17, P889, DOI 10.1097/JGP.0b013e3181b047e3
   Blum MR, 2016, NEUROENDOCRINOLOGY, V103, P291, DOI 10.1159/000437387
   Cameron AJ, 2008, OBESITY, V16, P2707, DOI 10.1038/oby.2008.412
   Chalasani N, 2012, GASTROENTEROLOGY, V142, P1592, DOI 10.1053/j.gastro.2012.04.001
   Chang Y, 2016, ANN INTERN MED, V164, P305, DOI 10.7326/M15-1323
   Cho MJ, 1998, PSYCHIAT RES, V81, P341, DOI 10.1016/S0165-1781(98)00122-X
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   Díaz-Martínez L, 2007, REV MED CHILE, V135, P990
   Eckel RH, 2010, LANCET, V375, P181, DOI 10.1016/S0140-6736(09)61794-3
   Ford ES, 2008, DIABETES CARE, V31, P1898, DOI 10.2337/dc08-0423
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Guentert D, 2014, IS IT CLIN USEFUL ID
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Hildrum B, 2009, ACTA PSYCHIAT SCAND, V120, P14, DOI 10.1111/j.1600-0447.2008.01315.x
   Hiles SA, 2016, DEPRESS ANXIETY, V33, P754, DOI 10.1002/da.22512
   Kim MD, 2007, INT J SOC PSYCHIATR, V53, P123, DOI 10.1177/0020764006075022
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Kinder LS, 2002, HEALTH PSYCHOL, V21, P542, DOI 10.1037//0278-6133.21.6.542
   Knol MJ, 2011, EUR J EPIDEMIOL, V26, P433, DOI 10.1007/s10654-011-9554-9
   Koskinen J, 2009, CIRCULATION, V120, P229, DOI 10.1161/CIRCULATIONAHA.108.845065
   Lorenzo C, 2007, DIABETES CARE, V30, P8, DOI 10.2337/dc06-1414
   Mancia G, 2010, J HYPERTENS, V28, P999, DOI 10.1097/HJH.0b013e328337a9e3
   McIntyre RS, 2012, ANN CLIN PSYCHIATRY, V24, P69
   Meigs JB, 2003, BRIT MED J, V327, P61, DOI 10.1136/bmj.327.7406.61
   Nabi H, 2011, HYPERTENSION, V57, P710, DOI 10.1161/HYPERTENSIONAHA.110.164061
   Nouwen A, 2010, DIABETOLOGIA, V53, P2480, DOI 10.1007/s00125-010-1874-x
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pulkki-Råback L, 2009, HEALTH PSYCHOL, V28, P108, DOI 10.1037/a0012646
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Royston P, 2002, STAT MED, V21, P2175, DOI 10.1002/sim.1203
   Ryu S, 2015, J HEPATOL, V62, P1164, DOI 10.1016/j.jhep.2014.11.041
   Takeuchi T, 2009, DIABETES-METAB RES, V25, P762, DOI 10.1002/dmrr.1041
   Tang F, 2017, PSYCHONEUROENDOCRINO, V77, P112, DOI 10.1016/j.psyneuen.2016.11.025
   Wannamethee SG, 2005, ARCH INTERN MED, V165, P2644, DOI 10.1001/archinte.165.22.2644
   Weber-Hamann B, 2006, PSYCHONEUROENDOCRINO, V31, P347, DOI 10.1016/j.psyneuen.2005.08.014
   Wen CP, 2009, PUBLIC HEALTH NUTR, V12, P497, DOI 10.1017/S1368980008002802
   Wilson PWF, 1999, ARCH INTERN MED, V159, P1104, DOI 10.1001/archinte.159.10.1104
   Wulsin LR, 1999, PSYCHOSOM MED, V61, P6, DOI 10.1097/00006842-199901000-00003
NR 42
TC 11
Z9 13
U1 0
U2 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD MAR 1
PY 2019
VL 246
BP 643
EP 651
DI 10.1016/j.jad.2018.12.073
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA HJ6EE
UT WOS:000457276200078
PM 30611062
DA 2025-06-11
ER

PT J
AU Luévano-Contreras, C
   Gómez-Ojeda, A
   Macías-Cervantes, MH
   Garay-Sevilla, ME
AF Luevano-Contreras, Claudia
   Gomez-Ojeda, Armando
   Habacuc Macias-Cervantes, Maciste
   Eugenia Garay-Sevilla, Ma
TI Dietary Advanced Glycation End Products and Cardiometabolic Risk
SO CURRENT DIABETES REPORTS
LA English
DT Review
DE Cardiometabolic risk; Advanced glycation end product; Maillard reaction;
   N-epsilon-(carboxymethyl)-lysine; Dietary AGEs
ID HEALTHY OVERWEIGHT INDIVIDUALS; RANDOMIZED CONTROLLED-TRIAL; TYPE-2
   DIABETES-MELLITUS; RENAL-FAILURE PATIENTS; OXIDATIVE STRESS; ENDOTHELIAL
   FUNCTION; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; MAILLARD REACTION
AB Purpose of Review This report analyzes emerging evidence about the role of dietary advanced glycation end products (AGEs) as a cardiometabolic risk factor. Two important aspects are discussed: First, the modulation of AGE load by dietary AGEs; second, if the evidence of clinical and observational studies is enough to make dietary recommendations towards lowering AGE intake.
   Recent Findings Clinical studies in subjects with diabetes mellitus have shown that high intake of dietary AGEs increases inflammation markers, oxidative stress, and could impair endothelial function. In subjects at risk for cardiometabolic diseases (with overweight, obesity, or prediabetes), dietary AGE restriction decreases some inflammatory molecules and improves insulin sensitivity. However, studies in healthy subjects are limited, and not all of the studies have shown a decrease in circulating AGEs. Therefore, it is still unclear if dietary AGEs represent a health concern for people potentially at risk for cardiometabolic diseases.
   Summary The evidence shows that dietary AGEs are bioavailable and absorbed, and the rate of excretion depends on dietary intake. The metabolic fate of most dietary AGEs remains unknown. Regardless, most studies have shown that by diminishing AGE intake, circulating levels will also decrease. Thus, dietary AGEs can modulate the AGE load at least in patients with DM, overweight, or obesity. Studies with specific clinical outcomes and large-scale observational studies are needed for a better risk assessment of dietary AGEs and to establish dietary recommendations accordingly.
C1 [Luevano-Contreras, Claudia; Gomez-Ojeda, Armando; Habacuc Macias-Cervantes, Maciste; Eugenia Garay-Sevilla, Ma] Univ Guanajuato, Dept Med Sci, 20 Enero 929, Guanajuato, Mexico.
C3 Universidad de Guanajuato
RP Luévano-Contreras, C (corresponding author), Univ Guanajuato, Dept Med Sci, 20 Enero 929, Guanajuato, Mexico.
EM c.luevanocontreras@ugto.mx
RI Luevano-Contreras, Claudia/ADJ-1806-2022
OI GOMEZ-OJEDA, ARMANDO/0009-0005-3711-8605; Luevano-Contreras,
   Claudia/0000-0002-2632-8093
CR Ahmed N, 2005, DIABETES RES CLIN PR, V67, P3, DOI 10.1016/j.diabres.2004.09.004
   Angoorani P, 2016, INT J FOOD SCI NUTR, V67, P170, DOI 10.3109/09637486.2015.1137889
   [Anonymous], 2014, FOOD CHEM TOXICOL IN, V64, P411, DOI [10.1016/j.fct.2013.12.001, DOI 10.1016/J.FCT.2013.12.001]
   Basta G, 2002, CIRCULATION, V105, P816, DOI 10.1161/hc0702.104183
   Basta G, 2004, CARDIOVASC RES, V63, P582, DOI 10.1016/j.cardiores.2004.05.001
   Bierhaus A, 2005, J MOL MED, V83, P876, DOI 10.1007/s00109-005-0688-7
   Birlouez-Aragon I, 2010, AM J CLIN NUTR, V91, P1220, DOI 10.3945/ajcn.2009.28737
   Cai WJ, 2012, P NATL ACAD SCI USA, V109, P15888, DOI 10.1073/pnas.1205847109
   Cai WJ, 2004, CIRCULATION, V110, P285, DOI 10.1161/01.CIR.0000135587.92455.0D
   Campbell DJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0049813
   Chao PC, 2009, FOOD CHEM, V113, P262, DOI 10.1016/j.foodchem.2008.06.076
   Chao PC, 2010, EUR J NUTR, V49, P429, DOI 10.1007/s00394-010-0101-3
   Chuah YK, 2013, INT J INFLAMM, V2013, DOI 10.1155/2013/403460
   Clarke RE, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030125
   Conthe P, 2008, REV CLIN ESP, V208, P63, DOI 10.1157/13115200
   Escobosa ARC, 2015, ANAL BIOANAL CHEM, V407, P1149, DOI 10.1007/s00216-014-8335-1
   Coughlan MT, 2011, DIABETES, V60, P2523, DOI 10.2337/db10-1033
   Couppé C, 2014, AGE, V36, DOI 10.1007/s11357-014-9665-9
   D'Agostino RB, 2013, GLOB HEART, V8, P11, DOI 10.1016/j.gheart.2013.01.001
   de Courten B, 2016, AM J CLIN NUTR, V103, P1426, DOI 10.3945/ajcn.115.125427
   Delgado-Andrade C, 2016, FOOD FUNCT, V7, P46, DOI [10.1039/c5fo00918a, 10.1039/C5FO00918A]
   Delgado-Andrade C, 2012, AMINO ACIDS, V43, P595, DOI 10.1007/s00726-011-1107-8
   Després JP, 2008, ARTERIOSCL THROM VAS, V28, P1039, DOI 10.1161/ATVBAHA.107.159228
   Di Pino A, 2016, J CLIN LIPIDOL, V10, P1098, DOI 10.1016/j.jacl.2016.07.001
   Erbersdobler HF, 2007, MOL NUTR FOOD RES, V51, P423, DOI 10.1002/mnfr.200600154
   Finot PA, 2005, ANN NY ACAD SCI, V1043, P1, DOI 10.1196/annals.1333.001
   Foerster A, 2003, BIOCHEM SOC T, V31, P1383, DOI 10.1042/BST0311383
   Forbes JM, 2014, AMINO ACIDS, V46, P321, DOI 10.1007/s00726-013-1542-9
   Geissler S, 2010, J AGR FOOD CHEM, V58, P2543, DOI 10.1021/jf903791u
   Ghanem AA, 2011, EUR J OPHTHALMOL, V21, P48, DOI 10.5301/EJO.2010.4447
   Giacco F, 2010, CIRC RES, V107, P1058, DOI 10.1161/CIRCRESAHA.110.223545
   Giorgino F, 2013, ANN NY ACAD SCI, V1281, P36, DOI 10.1111/nyas.12044
   Goon JA, 2009, J PHYS ACT HEALTH, V6, P43, DOI 10.1123/jpah.6.1.43
   Grossin N, 2015, MOL NUTR FOOD RES, V59, P927, DOI 10.1002/mnfr.201400643
   Macías-Cervantes MH, 2015, NUTRITION, V31, P446, DOI 10.1016/j.nut.2014.10.004
   Harcourt BE, 2011, KIDNEY INT, V80, P191, DOI 10.1038/ki.2011.57
   He CJ, 1999, DIABETES, V48, P1308, DOI 10.2337/diabetes.48.6.1308
   Hegab Z, 2012, WORLD J CARDIOL, V4, P90, DOI 10.4330/wjc.v4.i4.90
   Hellwig M, 2014, ANGEW CHEM INT EDIT, V53, P10316, DOI 10.1002/anie.201308808
   Hellwig M, 2014, AMINO ACIDS, V46, P289, DOI 10.1007/s00726-013-1501-5
   Hellwig M, 2011, CHEMBIOCHEM, V12, P1270, DOI 10.1002/cbic.201000759
   Henle T, 2003, KIDNEY INT, V63, pS145, DOI 10.1046/j.1523-1755.63.s84.16.x
   Hull GLJ, 2012, FOOD CHEM, V131, P170, DOI 10.1016/j.foodchem.2011.08.055
   Kislinger T, 1999, J BIOL CHEM, V274, P31740, DOI 10.1074/jbc.274.44.31740
   Koschinsky T, 1997, P NATL ACAD SCI USA, V94, P6474, DOI 10.1073/pnas.94.12.6474
   Lee I-Min, 2009, Pres Counc Phys Fit Sports Res Dig, V10, P1
   Li M, 2015, J AGR FOOD CHEM, V63, P10995, DOI 10.1021/acs.jafc.5b05750
   Lorenzi M, 2007, EXP DIABETES RES, DOI 10.1155/2007/61038
   Luevano-Contreras C, 2013, J EVID-BASED INTEGR, V18, P50, DOI 10.1177/2156587212460054
   Luévano-Contreras C, 2013, J CLIN BIOCHEM NUTR, V52, P22, DOI 10.3164/jcbn.12-40
   Lv X, 2016, CHIN J NAT MEDICINES, V14, P844, DOI 10.1016/S1875-5364(16)30101-7
   Macias-Cervantes MH, 2009, EUR J PEDIATR, V168, P1195, DOI 10.1007/s00431-008-0907-7
   Mark AB, 2014, DIABETES CARE, V37, P88, DOI 10.2337/dc13-0842
   Miyata T, 1998, KIDNEY INT, V53, P416, DOI 10.1046/j.1523-1755.1998.00756.x
   NEEPER M, 1992, J BIOL CHEM, V267, P14998
   Negrean M, 2007, AM J CLIN NUTR, V85, P1236, DOI 10.1093/ajcn/85.5.1236
   Neumann A, 1999, FEBS LETT, V453, P283, DOI 10.1016/S0014-5793(99)00731-0
   Ni JQ, 2009, MOL CELL PROTEOMICS, V8, P1921, DOI 10.1074/mcp.M900127-MCP200
   O'Donnel CJ, 2008, REV ESP CARDIOL, V61, P299, DOI 10.1016/S1885-5857(08)60118-8
   OBRIEN J, 1989, CRIT REV FOOD SCI, V28, P211, DOI 10.1080/10408398909527499
   Ott C, 2014, REDOX BIOL, V2, P411, DOI 10.1016/j.redox.2013.12.016
   Ottum MS, 2015, J CLIN BIOCHEM NUTR, V57, P1, DOI 10.3164/jcbn.15-3
   Peiretti PG, 2012, FOOD CHEM, V132, P80, DOI 10.1016/j.foodchem.2011.10.035
   Penfold SA, 2010, KIDNEY INT, V78, P287, DOI 10.1038/ki.2010.134
   Peppa M, 2004, AM J KIDNEY DIS, V43, P690, DOI 10.1053/j.ajkd.2003.11.022
   Poulsen MW, 2016, BRIT J NUTR, V115, P629, DOI 10.1017/S0007114515004833
   Poulsen MW, 2014, EUR J NUTR, V53, P661, DOI 10.1007/s00394-013-0574-y
   Poulsen MW, 2013, FOOD CHEM TOXICOL, V60, P10, DOI 10.1016/j.fct.2013.06.052
   Ramasamy R, 2005, GLYCOBIOLOGY, V15, p16R, DOI 10.1093/glycob/cwi053
   Rojas A, 2013, CELL SIGNAL, V25, P609, DOI 10.1016/j.cellsig.2012.11.022
   Roncero-Ramos I, 2014, J AGR FOOD CHEM, V62, P6001, DOI 10.1021/jf501005n
   Ross R, 2015, ANN INTERN MED, V162, P325, DOI 10.7326/M14-1189
   Scheijen JLJM, 2016, FOOD CHEM, V190, P1145, DOI 10.1016/j.foodchem.2015.06.049
   Semba RD, 2014, J NUTR, V144, P1037, DOI 10.3945/jn.113.189480
   Semba RD, 2010, EUR J APPL PHYSIOL, V108, P191, DOI 10.1007/s00421-009-1192-5
   Sharma C, 2015, J FOOD SCI TECH MYS, V52, P7561, DOI 10.1007/s13197-015-1851-y
   Simm A, 2013, J PROTEOMICS, V92, P248, DOI 10.1016/j.jprot.2013.05.012
   Somoza V, 2005, ANN NY ACAD SCI, V1043, P492, DOI 10.1196/annals.1333.056
   Stirban A, 2013, FOOD CHEM TOXICOL, V60, P10
   Stirban A, 2008, ANN NY ACAD SCI, V1126, P276, DOI 10.1196/annals.1433.042
   Stirban A, 2014, MOL METAB, V3, P94, DOI 10.1016/j.molmet.2013.11.006
   Tessier FJ, 2016, MOL NUTR FOOD RES, V60, P2446, DOI 10.1002/mnfr.201600140
   Thornalley PJ, 1998, CELL MOL BIOL, V44, P1013
   Tikellis C, 2008, AM J PHYSIOL-ENDOC M, V295, pE323, DOI 10.1152/ajpendo.00024.2008
   Uribarri J, 2003, AM J KIDNEY DIS, V42, P532, DOI 10.1016/S0272-6386(03)00779-0
   Uribarri J, 2007, J GERONTOL A-BIOL, V62, P427, DOI 10.1093/gerona/62.4.427
   Uribarri J, 2007, DIABETES CARE, V30, P2579, DOI 10.2337/dc07-0320
   Uribarri J, 2015, ADV NUTR, V6, P461, DOI 10.3945/an.115.008433
   Uribarri J, 2014, AMINO ACIDS, V46, P301, DOI 10.1007/s00726-013-1502-4
   Uribarri J, 2011, DIABETES CARE, V34, P1610, DOI 10.2337/dc11-0091
   Uribarri J, 2010, J AM DIET ASSOC, V110, P911, DOI 10.1016/j.jada.2010.03.018
   Vargas-Ortiz K, 2014, GAC MED MEX, V150, P120
   Vistoli G, 2013, FREE RADICAL RES, V47, P3, DOI 10.3109/10715762.2013.815348
   Vlassara H, 2002, P NATL ACAD SCI USA, V99, P15596, DOI 10.1073/pnas.242407999
   Vlassara H, 2016, DIABETOLOGIA, V59, P2181, DOI 10.1007/s00125-016-4053-x
   Vlassara H, 2014, CURR DIABETES REP, V14, DOI 10.1007/s11892-013-0453-1
   Vlassara H, 2009, J CLIN ENDOCR METAB, V94, P4483, DOI 10.1210/jc.2009-0089
   WHO, 2016, CARD DIS
   Xue J, 2011, STRUCTURE, V19, P722, DOI 10.1016/j.str.2011.02.013
   Yamagishi S, 2017, J DIABETES, V9, P141, DOI 10.1111/1753-0407.12475
   Yan SF, 2009, EXPERT REV MOL MED, V11, DOI 10.1017/S146239940900101X
   Yoshikawa T, 2009, MED SCI MONITOR, V15, pPH65
   Zhang QB, 2009, J PROTEOME RES, V8, P754, DOI 10.1021/pr800858h
   Zill H, 2003, BIOCHEM BIOPH RES CO, V300, P311, DOI 10.1016/S0006-291X(02)02856-5
NR 104
TC 54
Z9 59
U1 1
U2 47
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1534-4827
EI 1539-0829
J9 CURR DIABETES REP
JI Curr. Diabetes Rep.
PD AUG
PY 2017
VL 17
IS 8
AR 63
DI 10.1007/s11892-017-0891-2
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FA5GW
UT WOS:000405472100009
PM 28695383
DA 2025-06-11
ER

PT J
AU Smith, J
   Ferguson, D
   Jauregui, G
   Panarace, M
   Medina, M
   Lehnert, S
   Hill, JR
AF Smith, Jennifer
   Ferguson, Drewe
   Jauregui, Guillermo
   Panarace, Martin
   Medina, Mariano
   Lehnert, Sigrid
   Hill, Jonathan R.
TI Short-term maternal psychological stress in the post-conception period
   in ewes affects fetal growth and gestation length
SO REPRODUCTION
LA English
DT Article
ID PRENATAL STRESS; PERICONCEPTIONAL PERIOD; METABOLIC SYNDROME;
   BODY-WEIGHT; PROGESTERONE; EMBRYO; SHEEP; NUTRITION; PREGNANCY;
   SUPEROVULATION
AB Fetal development can be influenced by maternal environment in the peri-conceptional period. This study investigated the effect of maternal feed intake and psychological stress within the first 6 days after conception on embryo development and fetal growth. Superovulated ewes (n=40) were artificially inseminated with semen from one ram. Ewes were then divided into four groups (n=10): group 1 (control) was fed at maintenance level, group 2 (high) at 2 x maintenance, and group 3 (low) at 0.5 x maintenance on days 2-6 after conception. Group 4 (stress) was fed at maintenance level and then an intense physical and psychological stress challenge was applied for 1 h only on days 2 and 3 after conception. Embryos were recovered at day 6. A total of 113 transferable grade embryos were transferred singly into synchronized untreated recipients, while the remaining embryos (n=165) were fixed and stained for cell counts. Post-conception maternal stress or feed intake did not alter the cell count or grade of day 6 embryos. Fetuses from the stress group had longer crown-rump lengths at day 30 and longer femur length at day 58. Fetuses from the stressed and high feed groups had greater abdominal circumferences at day 85. Subsequent birth weights were not significantly different. Ewes carrying lambs from the stress treatment had shorter gestation lengths. These results show that short-term perturbations of the post-conception maternal environment have measurable effects on fetal development and gestation length.
C1 [Smith, Jennifer; Ferguson, Drewe; Hill, Jonathan R.] CSIRO Livestock Ind, FD McMaster Lab, Armidale, NSW 2350, Australia.
   [Jauregui, Guillermo; Panarace, Martin; Medina, Mariano] Goyaike SAACI & F Biotecnol Anim, RA-6725 Buenos Aires, DF, Argentina.
   [Lehnert, Sigrid] CSIRO Livestock Ind, Queensland Biotechnol Precinct, St Lucia, Qld 4067, Australia.
C3 Commonwealth Scientific & Industrial Research Organisation (CSIRO);
   Commonwealth Scientific & Industrial Research Organisation (CSIRO)
RP Hill, JR (corresponding author), Univ Queensland, St Lucia, Qld 4072, Australia.
EM jonathan.hill@uq.edu.au
RI Hill, Jonathan/AAF-7501-2021; Ferguson, Drewe/E-8342-2011; Lehnert,
   Sigrid/A-3676-2013
OI Hill, Jonathan/0000-0001-7640-0463; Lehnert, Sigrid/0000-0003-4891-9094
FU Goyaike SAACI y F Biotecnologia Animal, Buenos Aires, Argentina,; CSIRO
   Livestock Industries, Brisbane, Australia
FX This work was supported by funding front Goyaike SAACI y F Biotecnologia
   Animal, Buenos Aires, Argentina, and CSIRO Livestock Industries,
   Brisbane, Australia.
CR Abecia JA, 1997, ANIM REPROD SCI, V48, P209, DOI 10.1016/S0378-4320(97)00021-3
   Armitage JA, 2004, J PHYSIOL-LONDON, V561, P355, DOI 10.1113/jphysiol.2004.072009
   Beaujean N, 2004, CURR BIOL, V14, pR266, DOI 10.1016/j.cub.2004.03.019
   Bloomfield FH, 2003, SCIENCE, V300, P606, DOI 10.1126/science.1080803
   Dobson H, 2001, THERIOGENOLOGY, V55, P65, DOI 10.1016/S0093-691X(00)00446-5
   Dole N, 2003, AM J EPIDEMIOL, V157, P14, DOI 10.1093/aje/kwf176
   Edwards LJ, 2002, BIOL REPROD, V66, P1562, DOI 10.1095/biolreprod66.5.1562
   Fleming TP, 2004, BIOL REPROD, V71, P1046, DOI 10.1095/biolreprod.104.030957
   GARRETT JE, 1988, J REPROD FERTIL, V84, P437, DOI 10.1530/jrf.0.0840437
   Gilmour A.R., 2015, ASReml User Guide Release 4.1 Functional Specification
   Jansen S, 2006, REPRODUCTION, V131, P469, DOI 10.1530/rep.1.00953
   Jindal R, 1996, J ANIM SCI, V74, P620
   KLEEMANN DO, 1994, J REPROD FERTIL, V102, P411, DOI 10.1530/jrf.0.1020411
   Kofman O, 2002, NEUROSCI BIOBEHAV R, V26, P457, DOI 10.1016/S0149-7634(02)00015-5
   Lozano JM, 2003, REPRODUCTION, V125, P543, DOI 10.1530/reprod/125.4.543
   MacLaughlin SM, 2005, J PHYSIOL-LONDON, V565, P111, DOI 10.1113/jphysiol.2005.084996
   McEvoy TG, 1997, ANIM REPROD SCI, V47, P71, DOI 10.1016/S0378-4320(96)01627-2
   McMillen IC, 2005, PHYSIOL REV, V85, P571, DOI 10.1152/physrev.00053.2003
   Mueller BR, 2006, PHYSIOL BEHAV, V88, P605, DOI 10.1016/j.physbeh.2006.05.019
   Nolan R, 1998, THERIOGENOLOGY, V50, P1263, DOI 10.1016/S0093-691X(98)00225-8
   Oliver M H, 2007, Soc Reprod Fertil Suppl, V64, P397
   Pantaleon M, 1998, REV REPROD, V3, P77, DOI 10.1530/revreprod/3.2.77
   PARR RA, 1987, J REPROD FERTIL, V80, P317, DOI 10.1530/jrf.0.0800317
   Paull DR, 2007, AUST VET J, V85, P98, DOI 10.1111/j.1751-0813.2007.00115.x
   Quigley SP, 2005, ANIM REPROD SCI, V87, P241, DOI 10.1016/j.anireprosci.2004.11.005
   Sapolsky RM., 2002, BEHAV ENDOCRINOLOGY
   SCHNEIDER ML, 1992, DEV PSYCHOBIOL, V25, P529, DOI 10.1002/dev.420250706
   Thouas G. A., 2001, Reprod Biomed Online, V3, P25
   Wadhwa P D, 2001, Matern Child Health J, V5, P119, DOI 10.1023/A:1011353216619
   Walker SK, 1996, THERIOGENOLOGY, V45, P111, DOI 10.1016/0093-691X(95)00360-K
   Wallace JM, 2003, REPRODUCTION, V126, P481, DOI 10.1530/reprod/126.4.481
   Wallace JM, 1999, BIOL REPROD, V61, P101, DOI 10.1095/biolreprod61.1.101
NR 32
TC 13
Z9 15
U1 0
U2 10
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 1470-1626
J9 REPRODUCTION
JI Reproduction
PD AUG
PY 2008
VL 136
IS 2
BP 259
EP 265
DI 10.1530/REP-07-0400
PG 7
WC Developmental Biology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology; Reproductive Biology
GA 340UW
UT WOS:000258671500013
PM 18469037
OA Bronze
DA 2025-06-11
ER

PT J
AU dos Santos, A
   Galiè, S
AF dos Santos, Adriano
   Galie, Serena
TI The Microbiota-Gut-Brain Axis in Metabolic Syndrome and Sleep Disorders:
   A Systematic Review
SO NUTRIENTS
LA English
DT Review
DE dysbiosis; gut microbiome; microbiome metabolites; metabolic syndrome;
   sleep quality; sleep efficiency
ID CARDIOMETABOLIC RISK-FACTORS; MEDITERRANEAN DIET; HEALTHY-INDIVIDUALS;
   CIRCADIAN-RHYTHMS; OXIDATIVE STRESS; QUALITY INDEX; INFLAMMATION;
   INTERVENTION; CLOCK; METAANALYSIS
AB Background: Over recent decades, a growing body of evidence has emerged linking the composition of the gut microbiota to sleep regulation. Interestingly, the prevalence of sleep disorders is commonly related to cardiometabolic comorbidities such as diabetes, impaired lipid metabolism, and metabolic syndrome (MetS). In this complex scenario, the role of the gut-brain axis as the main communicating pathway between gut microbiota and sleep regulation pathways in the brain reveals some common host-microbial biomarkers in both sleep disturbances and MetS. As the biological mechanisms behind this complex interacting network of neuroendocrine, immune, and metabolic pathways are not fully understood yet, the present systematic review aims to describe common microbial features between these two unrelated chronic conditions. Results: This systematic review highlights a total of 36 articles associating the gut microbial signature with MetS or sleep disorders. Specific emphasis is given to studies evaluating the effect of dietary patterns, dietary supplementation, and probiotics on MetS or sleep disturbances. Conclusions: Dietary choices promote microbial composition and metabolites, causing both the amelioration and impairment of MetS and sleep homeostasis.
C1 [dos Santos, Adriano] Integrat Med Nutr Dept, ADS Vital BV, NL-2517 AS The Hague, Netherlands.
   [Galie, Serena] European Inst Oncol IRCCS, Dept Expt Oncol, I-20139 Milan, Italy.
C3 IRCCS European Institute of Oncology (IEO)
RP dos Santos, A (corresponding author), Integrat Med Nutr Dept, ADS Vital BV, NL-2517 AS The Hague, Netherlands.
EM adriano.dossantos@students.unibe.ch; serena.galie@ieo.it
RI Santos, Adriano/ABH-6885-2020; Galié, Serena/AAC-6861-2022
OI dos Santos, Adriano/0009-0002-5069-076X; Galie,
   Serena/0000-0003-4431-3140
FU Integrative Medicine Nutrition Department, ADS Vitality B.V.; ADS
   Vitality Integrative Medicine Nutrition Centre; Royal Society of
   Medicine
FX This work was supported by the ADS Vitality Integrative Medicine
   Nutrition Centre. An external librarian, Beata Coffey, from The Royal
   Society of Medicine, provided the literature search and first screening
   process. A.D.S., an expert in nutrition and sleep disturbances, and
   S.G., an expert in nutrition and gut microbiota, were independently
   involved in the quality assessment of the selected articles. A.D.S. was
   involved in the design, drafting, and editing procedures of the
   manuscript.
CR Akamine Y, 2022, NUTR RES, V103, P68, DOI 10.1016/j.nutres.2022.03.013
   [Anonymous], 2004, The Rhythms Of Life: The Biological Clocks That Control the Daily Lives of Every Living Thing
   Asnicar F, 2021, NAT MED, V27, P321, DOI 10.1038/s41591-020-01183-8
   Barrett E, 2012, J APPL MICROBIOL, V113, P411, DOI 10.1111/j.1365-2672.2012.05344.x
   Bechtel W, 2015, FRONT PSYCHIATRY, V6, DOI 10.3389/fpsyt.2015.00118
   Bellikci-Koyu E, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092089
   Binks H, 2020, NUTRIENTS, V12, DOI 10.3390/nu12040936
   Bonnet M H, 1997, Sleep Med Rev, V1, P97, DOI 10.1016/S1087-0792(97)90012-5
   Bravo JA, 2011, P NATL ACAD SCI USA, V108, P16050, DOI 10.1073/pnas.1102999108
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1016/0165-1781(89)90047-4
   Cai HH, 2021, HUM BRAIN MAPP, V42, P3088, DOI 10.1002/hbm.25419
   Carley David W, 2016, Diabetes Spectr, V29, P5, DOI 10.2337/diaspect.29.1.5
   Chattu VK, 2018, HEALTHCARE-BASEL, V7, DOI 10.3390/healthcare7010001
   Chokroverty S, 2010, INDIAN J MED RES, V131, P126
   D'Agostino RB, 2008, CIRCULATION, V117, P743, DOI 10.1161/CIRCULATIONAHA.107.699579
   David LA, 2014, GENOME BIOL, V15, DOI 10.1186/gb-2014-15-7-r89
   Diez-Gutiérrez L, 2020, J FUNCT FOODS, V64, DOI 10.1016/j.jff.2019.103669
   Dogra SK, 2020, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.572921
   Dubowy C, 2017, GENETICS, V205, P1373, DOI 10.1534/genetics.115.185157
   Eban-Rothschild A, 2018, NEUROPSYCHOPHARMACOL, V43, P937, DOI 10.1038/npp.2017.294
   Eriksen AK, 2020, AM J CLIN NUTR, V111, P864, DOI 10.1093/ajcn/nqaa026
   Fabbri M, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18031082
   Fan Y, 2021, NAT REV MICROBIOL, V19, P55, DOI 10.1038/s41579-020-0433-9
   Foster RG, 2020, INTERFACE FOCUS, V10, DOI 10.1098/rsfs.2019.0098
   Foster RG, 2014, EXP PHYSIOL, V99, P599, DOI 10.1113/expphysiol.2012.071118
   Froy O, 2010, ENDOCR REV, V31, P1, DOI 10.1210/er.2009-0014
   Galié S, 2021, MOL NUTR FOOD RES, V65, DOI 10.1002/mnfr.202000982
   Galié S, 2021, CLIN NUTR, V40, P3798, DOI 10.1016/j.clnu.2021.04.028
   Gao T, 2023, MICROBIOL SPECTR, V11, DOI 10.1128/spectrum.02000-22
   Gianfredi V, 2018, ANN IG MED PREV COMU, V30, P470, DOI 10.7416/ai.2018.2258
   Gilijamse PW, 2020, NPJ BIOFILMS MICROME, V6, DOI 10.1038/s41522-020-0127-0
   Grosicki GJ, 2020, SLEEP MED, V73, P76, DOI 10.1016/j.sleep.2020.04.013
   Guevara-Cruz M, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.119.012401
   Gulia KK, 2018, PSYCHOGERIATRICS, V18, P155, DOI 10.1111/psyg.12319
   Guo Y, 2021, J CLIN ENDOCR METAB, V106, P64, DOI 10.1210/clinem/dgaa644
   Hanson J A., 2023, StatPearls
   Haro C, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201700300
   Hibberd AA, 2019, BENEF MICROBES, V10, P121, DOI [10.3920/BM2018.0028, 10.3920/bm2018.0028]
   Hinz A, 2017, SLEEP MED, V30, P57, DOI 10.1016/j.sleep.2016.03.008
   Hjorth MF, 2019, INT J OBESITY, V43, P149, DOI 10.1038/s41366-018-0093-2
   Ho YT, 2021, NUTRIENTS, V13, DOI 10.3390/nu13082820
   Hwang JH, 2022, EPIDEMIOL HEALTH, V44, DOI 10.4178/epih.e2022022
   Ismael S, 2021, NUTRIENTS, V13, DOI 10.3390/nu13041228
   León-Pedroza JI, 2015, CIR CIR, V83, P543, DOI 10.1016/j.circir.2015.05.041
   Kahrstrom C., 2014, Nat. Rev. Microbiol, V12, DOI [10.1038/nrmicro3373, DOI 10.1038/NRMICRO3373]
   Kay DB, 2017, BRAIN SCI, V7, DOI 10.3390/brainsci7030023
   Kjolbæk L, 2020, CLIN NUTR, V39, P67, DOI 10.1016/j.clnu.2019.01.012
   Kubo M, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.552188
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Leone V, 2015, CELL HOST MICROBE, V17, P681, DOI 10.1016/j.chom.2015.03.006
   Lewy AJ, 1998, ARCH GEN PSYCHIAT, V55, P890, DOI 10.1001/archpsyc.55.10.890
   Li DY, 2000, ARTERIOSCL THROM VAS, V20, P1116, DOI 10.1161/01.ATV.20.4.1116
   Li YY, 2020, NAT SCI SLEEP, V12, P895, DOI 10.2147/NSS.S271927
   Liang YY, 2023, J TRANSL MED, V21, DOI 10.1186/s12967-023-03920-2
   Logan RW, 2019, NAT REV NEUROSCI, V20, P49, DOI 10.1038/s41583-018-0088-y
   Ma DL, 2004, INFECT IMMUN, V72, P5308, DOI 10.1128/IAI.72.9.5308-5314.2004
   Marungruang N, 2018, EUR J NUTR, V57, P2927, DOI 10.1007/s00394-017-1563-3
   Meslier V, 2020, GUT, V69, P1258, DOI 10.1136/gutjnl-2019-320438
   Mishra SP, 2023, GUT, V72, P1848, DOI 10.1136/gutjnl-2022-327365
   MOLDOFSKY H, 1989, FASEB J, V3, P1972, DOI 10.1096/fasebj.3.8.2785942
   Mukherji A, 2013, CELL, V153, P812, DOI 10.1016/j.cell.2013.04.020
   Müller M, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-48775-0
   Muralidharan J, 2021, AM J CLIN NUTR, V114, P1148, DOI 10.1093/ajcn/nqab150
   Nilsson AC, 2015, BRIT J NUTR, V114, P899, DOI 10.1017/S0007114515002524
   Nishida K, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081859
   Nutt David, 2008, Dialogues Clin Neurosci, V10, P329
   Ohayon MM, 2004, SLEEP, V27, P1255, DOI 10.1093/sleep/27.7.1255
   Oonk M, 2016, SLEEP, V39, P1467, DOI 10.5665/sleep.5984
   Page MJ, 2021, BMJ-BRIT MED J, V372, DOI [10.1136/bmj.n71, 10.1136/bmj.n160]
   Papandreou C, 2020, INT J OBESITY, V44, P330, DOI 10.1038/s41366-019-0401-5
   Parker A, 2020, GUT MICROBES, V11, P135, DOI 10.1080/19490976.2019.1638722
   Paschos GK, 2017, TRENDS GENET, V33, P760, DOI 10.1016/j.tig.2017.07.010
   Perry RJ, 2016, NATURE, V534, P213, DOI 10.1038/nature18309
   Proença IM, 2020, NUTR RES, V83, P1, DOI 10.1016/j.nutres.2020.06.018
   Rabiei S, 2019, J DIET SUPPL, V16, P294, DOI 10.1080/19390211.2018.1455788
   Reddy S., 2023, StatPearls
   Reppert SM, 2001, ANNU REV PHYSIOL, V63, P647, DOI 10.1146/annurev.physiol.63.1.647
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Roager HM, 2019, GUT, V68, P83, DOI 10.1136/gutjnl-2017-314786
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Rothschild D, 2018, NATURE, V555, P210, DOI 10.1038/nature25973
   Sangouni AA, 2023, PHYTOTHER RES, V37, P2305, DOI 10.1002/ptr.7741
   Schaafsma A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13072204
   Schmitt K, 2018, CELL METAB, V27, P657, DOI 10.1016/j.cmet.2018.01.011
   Selber-Hnatiw S, 2020, MICROBIOL-SGM, V166, P96, DOI 10.1099/mic.0.000853
   Sgro M, 2022, SLEEP, V45, DOI 10.1093/sleep/zsab268
   Sutanto CN, 2022, NUTR REV, V80, P306, DOI 10.1093/nutrit/nuab027
   Tang SS, 2022, WORLD J GASTROENTERO, V28, P2320, DOI 10.3748/wjg.v28.i21.2320
   Thaiss CA, 2016, CELL, V167, P1495, DOI 10.1016/j.cell.2016.11.003
   Thomas MS, 2022, NUTRIENTS, V14, DOI 10.3390/nu14061179
   Tian RP, 2022, MEDIAT INFLAMM, V2022, DOI 10.1155/2022/2078520
   van der Horst GTJ, 1999, NATURE, V398, P627, DOI 10.1038/19323
   Velikonja A, 2019, ANAEROBE, V55, P67, DOI 10.1016/j.anaerobe.2018.11.002
   Vgontzas AN, 2004, J CLIN ENDOCR METAB, V89, P2119, DOI 10.1210/jc.2003-031562
   Wang S, 2021, MOL NUTR FOOD RES, V65, DOI 10.1002/mnfr.202001051
   Wang XJ, 2021, INT J ENDOCRINOL, V2021, DOI 10.1155/2021/5579369
   Wang XT, 2023, MICROBIOME, V11, DOI 10.1186/s40168-022-01452-3
   Wang Z, 2022, SLEEP MED REV, V65, DOI 10.1016/j.smrv.2022.101691
   Wastyk HC, 2023, GUT MICROBES, V15, DOI 10.1080/19490976.2023.2178794
   Xiao SM, 2014, FEMS MICROBIOL ECOL, V87, P357, DOI 10.1111/1574-6941.12228
   Yang XQ, 2021, BIOMED RES INT, V2021, DOI 10.1155/2021/9979511
   Yao YF, 2022, FRONT BEHAV NEUROSCI, V16, DOI 10.3389/fnbeh.2022.877256
   Yao ZW, 2021, SLEEP BREATH, V25, P1655, DOI 10.1007/s11325-020-02246-3
   Yoon MS, 2016, NUTRIENTS, V8, DOI 10.3390/nu8070405
   Zhanfeng N, 2022, FRONT NEUROSCI-SWITZ, V16, DOI 10.3389/fnins.2022.934822
   Zhang SL, 2017, P NATL ACAD SCI USA, V114, pE1564, DOI 10.1073/pnas.1620673114
   Zhenyukh O, 2017, FREE RADICAL BIO MED, V104, P165, DOI 10.1016/j.freeradbiomed.2017.01.009
   Zhu RZ, 2023, FRONT IMMUNOL, V14, DOI 10.3389/fimmu.2023.1158137
   Zhu WF, 2016, CELL, V165, P111, DOI 10.1016/j.cell.2016.02.011
NR 109
TC 16
Z9 16
U1 12
U2 21
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2024
VL 16
IS 3
AR 390
DI 10.3390/nu16030390
PG 24
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HM7M6
UT WOS:001159988000001
PM 38337675
OA gold
DA 2025-06-11
ER

PT J
AU Rhon, DI
   Greenlee, TA
   Marchant, BG
   Sissel, CD
   Cook, CE
AF Rhon, Daniel, I
   Greenlee, Tina A.
   Marchant, Bryant G.
   Sissel, Charles Dennis
   Cook, Chad E.
TI Comorbidities in the first 2 years after arthroscopic hip surgery:
   substantial increases in mental health disorders, chronic pain,
   substance abuse and cardiometabolic conditions
SO BRITISH JOURNAL OF SPORTS MEDICINE
LA English
DT Article
ID PHYSICAL-ACTIVITY; FEMOROACETABULAR IMPINGEMENT; METABOLIC SYNDROME;
   SLEEP DISTURBANCE; MORTALITY; EXERCISE; COMPLICATIONS; RISK; CARE;
   EPIDEMIOLOGY
AB Objectives We aimed to identify the rate of seven comorbidities (mental health disorders, chronic pain, substance abuse disorders, cardiovascular disorders, metabolic syndrome, systemic arthropathy and sleep disorders) that occurred within 2 years after hip arthroscopy.
   Methods Data from individuals (ages 18-50 years) undergoing arthroscopic hip surgery between 2004 and 2013 were collected from the Military Health System (MHS) Data Repository (MDR). The MDR captures all healthcare encounters in all settings and locations for individuals within the MHS. Person-level data over 36 months were pulled and aggregated. Seven comorbidities related to poor outcomes from musculoskeletal disorders (mental health disorders, chronic pain, substance abuse disorders, cardiovascular disorders, metabolic syndrome, systemic arthropathy and sleep disorders) were examined 12 months prior and 24 months after surgery. Changes in frequencies were calculated as were differences in proportions between presurgery and postsurgery.
   Results 1870 subjects were identified (mean age 32.24 years; 55.5% men) and analysed. There were statistically significant increases (p<0.001) proportionally for all comorbidities after surgery. Relative to baseline, cases of mental health disorders rose 84%, chronic pain diagnoses increased 166%, substance abuse disorders rose 57%, cardiovascular disorders rose by 71%, metabolic syndrome cases rose 85.9%, systemic arthropathy rose 132% and sleep disorders rose 111%.
   Conclusions Major (potentially ' hidden') clinical comorbidities increased substantially after elective arthroscopic hip surgery when compared with preoperative status. These comorbidities appear to have been overlooked in major studies evaluating the benefits and risks of arthroscopic hip surgery. Level of evidence Prognostic, level III.
C1 [Rhon, Daniel, I; Greenlee, Tina A.] Brooke Army Med Ctr, Ctr Intrepid, Dept Rehabil Med, San Antonio, TX 78234 USA.
   [Rhon, Daniel, I] Baylor Univ, Doctoral Program Phys Therapy, Ft Sam Houston, TX USA.
   [Marchant, Bryant G.] Madigan Army Med Ctr, Dept Orthopaed & Rehabil, Tacoma, WA 98431 USA.
   [Sissel, Charles Dennis] Us Army Med Command, Program Anal & Evaluat Div, Ft Sam Houston, TX USA.
   [Cook, Chad E.] Duke Univ, Dept Orthoped, Div Phys Therapy, Durham, NC USA.
C3 United States Department of Defense; United States Army; San Antonio
   Military Medical Center; Baylor University; Madigan Army Medical Center;
   United States Department of Defense; United States Army; Duke University
RP Rhon, DI (corresponding author), Brooke Army Med Ctr, Dept Rehabil Med, San Antonio, TX 78234 USA.
EM daniel_rhon@baylor.edu
RI Rhon, Daniel/C-9542-2011
OI Rhon, Daniel/0000-0002-4320-990X; Cook, Chad/0000-0001-8622-8361;
   Greenlee, Tina/0000-0002-0638-5998
FU US Defense Health Agency [W911Qy-15-1-0016]
FX This research was supported by an internal grant from the US Defense
   Health Agency (W911Qy-15-1-0016).
CR Alsaadi SM, 2014, CLIN J PAIN, V30, P755, DOI 10.1097/AJP.0000000000000055
   Anokye NK, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-624
   Archer KR, 2014, SPINE J, V14, P759, DOI 10.1016/j.spinee.2013.06.087
   Bankoski A, 2011, DIABETES CARE, V34, P497, DOI 10.2337/dc10-0987
   Barnett K, 2012, LANCET, V380, P37, DOI 10.1016/S0140-6736(12)60240-2
   Benchimol EI, 2015, PLOS MED, V12, DOI 10.1371/journal.pmed.1001885
   Biswas A, 2015, ANN INTERN MED, V162, P123, DOI 10.7326/M14-1651
   Bize R, 2007, PREV MED, V45, P401, DOI 10.1016/j.ypmed.2007.07.017
   Booth FW, 2012, COMPR PHYSIOL, V2, P1143, DOI 10.1002/cphy.c110025
   Bray RM, 2010, MIL MED, V175, P390, DOI 10.7205/MILMED-D-09-00132
   Chauhan JS, 2013, PLOS ONE, V8, DOI [10.1371/journal.pone.0080000, 10.1371/journal.pone.0067008]
   Chomistek AK, 2013, J AM COLL CARDIOL, V61, P2346, DOI 10.1016/j.jacc.2013.03.031
   Coren Stanley, 2009, Physiotherapy Theory and Practice, V25, P442, DOI 10.1080/09593980902835351
   Cronin AJ, 2001, SLEEP, V24, P39, DOI 10.1093/sleep/24.1.39
   Dutton JR, 2016, ARTHROSCOPY, V32, P2251, DOI 10.1016/j.arthro.2016.05.042
   Ernat JJ, 2015, J BONE JOINT SURG AM, V97A, P1272, DOI 10.2106/JBJS.O.00043
   Fullagar HHK, 2015, SPORTS MED, V45, P161, DOI 10.1007/s40279-014-0260-0
   Gabbe BJ, 2013, BMC HEALTH SERV RES, V13, DOI 10.1186/1472-6963-13-30
   Gadermann AM, 2012, DEPRESS ANXIETY, V29, P797, DOI 10.1002/da.21924
   Garcia GH, 2016, ORTHOPEDICS, V39, P309, DOI 10.3928/01477447-20160517-03
   Ghoneim MM, 2016, BMC SURG, V16, DOI 10.1186/s12893-016-0120-y
   Gillison FB, 2009, SOC SCI MED, V68, P1700, DOI 10.1016/j.socscimed.2009.02.028
   Gironda RJ, 2006, PAIN MED, V7, P339, DOI 10.1111/j.1526-4637.2006.00146.x
   Griffiths MF, 2005, J ADV NURS, V49, P245, DOI 10.1111/j.1365-2648.2004.03283.x
   Hammett T, 2018, ARTHRIT CARE RES, V70, P892, DOI 10.1002/acr.23415
   Harding P, 2014, CLIN ORTHOP RELAT R, V472, P1502, DOI 10.1007/s11999-013-3427-3
   Hart R, 2013, SPINE, V38, P1508, DOI 10.1097/BRS.0b013e318285f05a
   Hoogeboom TJ, 2014, CURR OPIN ANESTHESIO, V27, P161, DOI 10.1097/ACO.0000000000000062
   Horneff JG, 2017, AM J SPORT MED, V45, P1670, DOI 10.1177/0363546517692551
   Jeffery DD, 2014, MIL MED, V179, P1141, DOI 10.7205/MILMED-D-14-00002
   Kahlenberg CA, 2014, ORTHOP J SPORTS MED, V2, DOI 10.1177/2325967114523916
   Kessler RC, 2005, ARCH GEN PSYCHIAT, V62, P593, DOI 10.1001/archpsyc.62.6.593
   Kierkegaard S, 2017, BRIT J SPORT MED, V51, P572, DOI 10.1136/bjsports-2016-096618
   Koorevaar RCT, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0166555
   Lentz TA, 2016, J ORTHOP SPORT PHYS, V46, P327, DOI 10.2519/jospt.2016.6487
   Loprinzi PD, 2018, AM J HLTH PROMOT, V32
   Morales-Espinoza EM, 2016, PAIN, V157, P818, DOI 10.1097/j.pain.0000000000000440
   Memtsoudis SG, 2014, ANESTH ANALG, V118, P407, DOI 10.1213/ANE.0000000000000051
   Menendez ME, 2015, CLIN ORTHOP RELAT R, V473, P2402, DOI 10.1007/s11999-015-4173-5
   Mikkelsen K, 2017, MATURITAS, V106, P48, DOI 10.1016/j.maturitas.2017.09.003
   Mysliwiec V, 2013, SLEEP, V36, P167, DOI 10.5665/sleep.2364
   Nakano N, 2016, MLTJ-MUSCLE LIGAMENT, V6, P402, DOI 10.11138/mltj/2016.6.3.402
   Pedersen BK, 2006, SCAND J MED SCI SPOR, V16, P3, DOI 10.1111/j.1600-0838.2006.00520.x
   Piccirillo JF, 2008, CRIT REV ONCOL HEMAT, V67, P124, DOI 10.1016/j.critrevonc.2008.01.013
   Rabbitts JA, 2014, CLIN J PAIN, V30, P251, DOI 10.1097/AJP.0b013e31829550c6
   Rhon DI, 2018, BMC MED INFORM DECIS, V18, DOI 10.1186/s12911-018-0588-8
   Rotevatn TA, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0173083
   Santiago-Torres J, 2015, AM J SPORT MED, V43, P745, DOI 10.1177/0363546514533776
   Schnaser EA, 2016, J ARTHROPLASTY, V31, P2286, DOI 10.1016/j.arth.2016.03.023
   Schoenfeld AJ, 2013, SPINE J, V13, P1171, DOI 10.1016/j.spinee.2013.02.071
   Smith Mark A, 2011, Front Psychiatry, V2, P82, DOI 10.3389/fpsyt.2011.00082
   Smith TO, 2015, POSTGRAD MED J, V91, P483, DOI 10.1136/postgradmedj-2015-133507
   Sudarshan M, 2015, J SURG RES, V193, P868, DOI 10.1016/j.jss.2014.09.007
   Tang NKY, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0092158
   Valderas JM, 2009, ANN FAM MED, V7, P357, DOI 10.1370/afm.983
   Visser A, 2015, SURGERY, V158, P58, DOI 10.1016/j.surg.2015.01.012
   von Elm E, 2008, J CLIN EPIDEMIOL, V61, P344, DOI 10.2471/BLT.07.045120
   Weledji EP, 2014, INT J SURG RES, V3, P1
   Withers TM, 2017, CLIN REHABIL, V31, P639, DOI 10.1177/0269215516673884
NR 59
TC 20
Z9 20
U1 0
U2 5
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0306-3674
EI 1473-0480
J9 BRIT J SPORT MED
JI Br. J. Sports Med.
PD MAY
PY 2019
VL 53
IS 9
BP 547
EP +
DI 10.1136/bjsports-2018-099294
PG 8
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Sport Sciences
GA IA3YG
UT WOS:000469498500009
PM 30262452
DA 2025-06-11
ER

PT J
AU Mangurian, C
   Thomas, MD
   Mitsuishi, F
   Goldman, LE
   Niu, G
   Handley, MA
   Riano, NS
   Hwong, A
   Essock, S
   Dilley, J
   Newcomer, JW
   Schillinger, D
AF Mangurian, Christina
   Thomas, Marilyn D.
   Mitsuishi, Fumi
   Goldman, L. Elizabeth
   Niu, Grace
   Handley, Margaret A.
   Riano, Nicholas S.
   Hwong, Alison
   Essock, Susan
   Dilley, James
   Newcomer, John W.
   Schillinger, Dean
TI Lessons Learned From a New Reverse-Integration Model to Improve Primary
   Care Screening in Community Mental Health Settings
SO PSYCHIATRIC SERVICES
LA English
DT Article
AB The authors sought to describe a reverse-integration intervention aimed at improving preventive health screening in a community mental health clinic. The intervention, CRANIUM (cardiometabolic risk assessment and treatment through a novel integration model for underserved populations with mental illness), integrated primary care services into a large urban community mental health setting. It was implemented in 2015 and included a patient- centered team, population-based care, emphasis on screening, and evidence-based treatment. CRANIUM's strengths included provider acceptability, a patient-centered approach, sustained patient engagement, and economic feasibility. Challenges included underutilized staff, registry maintenance, and unanticipated screening barriers. The CRANIUM reverseintegration model can be feasibly implemented and was acceptable to providers.
C1 [Mangurian, Christina; Thomas, Marilyn D.; Mitsuishi, Fumi; Niu, Grace; Riano, Nicholas S.; Hwong, Alison; Dilley, James] Univ Calif San Francisco, Weill Inst Neurosci, Dept Psychiat & Behav Sci, San Francisco, CA 94143 USA.
   [Mangurian, Christina; Handley, Margaret A.] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
   [Goldman, L. Elizabeth; Handley, Margaret A.; Schillinger, Dean] San Francisco Gen Hosp, Dept Med, Div Gen Internal Med, San Francisco, CA 94110 USA.
   [Essock, Susan] Columbia Univ, Dept Psychiat, New York, NY USA.
   [Newcomer, John W.] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO USA.
   [Newcomer, John W.] Thriving Mind South Florida, Miami, FL USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   San Francisco General Hospital Medical Center; Columbia University;
   Washington University (WUSTL)
RP Mangurian, C (corresponding author), Univ Calif San Francisco, Weill Inst Neurosci, Dept Psychiat & Behav Sci, San Francisco, CA 94143 USA.; Mangurian, C (corresponding author), Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
RI Riano, Nicholas/LIH-0953-2024
OI Hwong, Alison/0000-0002-7443-8019
FU National Institute of Mental Health [K23 MH-093689, R01 MH-112420]; UCSF
   Hellman Fellows Award for Early-Career Faculty; National Center for
   Research Resources; National Center for Advancing Translational
   Sciences; Office of the Director, National Institutes of Health (NIH),
   through the UCSF-Clinical and Translational Science Institute [KL2
   RR-024130]; NIH Center grant from the National Institute of Diabetes and
   Digestive and Kidney Diseases for the Health Delivery Systems-Center for
   Diabetes Translational Research (CDTR) [P30 DK-092924]; Ford Foundation
   fellowship; NIH Ruth L. Kirschstein National Research Service award
   [2T32 MH-018261]; NIH Center grant from the National Institute of
   Diabetes and Digestive and Kidney Diseases for the Health Delivery
   Systems-CDTR [P30 DK-092924]; NIH-National Institute of Minority Health
   and Health Disparities Comprehensive Center of Excellence for Health and
   Risk in Minority Youth and Young Adults [P60 MD-006902]; American
   Psychiatric Association Foundation; National Institute of Mental Health
   Research Education grant [R25 MH-060482]; Substance Abuse and Mental
   Health Services Administration [H79SM080142]; NIH [MH-118395,
   MH-106682]; State of Florida Department of Children and Families
   [KH225]; National Institute of Mental Health [R25MH060482, T32MH018261,
   R34MH118395, R01MH112420] Funding Source: NIH RePORTER
FX Dr. Mangurian was supported by the National Institute of Mental Health
   (grants K23 MH-093689 and R01 MH-112420); the UCSF Hellman Fellows Award
   for Early-Career Faculty; and the National Center for Research
   Resources, the National Center for Advancing Translational Sciences, and
   the Office of the Director, National Institutes of Health (NIH), through
   the UCSF-Clinical and Translational Science Institute (grant KL2
   RR-024130). Dr. Mangurian and Mr. Riano were supported by an NIH Center
   grant (P30 DK-092924) from the National Institute of Diabetes and
   Digestive and Kidney Diseases for the Health Delivery Systems-Center for
   Diabetes Translational Research (CDTR). Dr. Thomas was supported by a
   Ford Foundation fellowship administered by the National Academies of
   Sciences, Engineering, and Medicine. Dr. Niu was supported by an NIH
   Ruth L. Kirschstein National Research Service award (2T32 MH-018261).
   Drs. Handley and Schillinger were supported by an NIH Center grant from
   the National Institute of Diabetes and Digestive and Kidney Diseases for
   the Health Delivery Systems-CDTR (P30 DK-092924) and the NIH-National
   Institute of Minority Health and Health Disparities Comprehensive Center
   of Excellence for Health and Risk in Minority Youth and Young Adults
   (P60 MD-006902). Dr. Hwong was supported by the American Psychiatric
   Association Foundation and by a National Institute of Mental Health
   Research Education grant (R25 MH-060482). In the past 3 years, Dr.
   Newcomer has received grant support from the Substance Abuse and Mental
   Health Services Administration (grant H79SM080142), the NIH (MH-118395
   and MH-106682), and the State of Florida Department of Children and
   Families (KH225). The authors thank the patients and staff at the
   Citywide Focus Clinic, UCSF. The authors also thank several
   administrators within the San Francisco Department of Public Health,
   including David Fariello, L.C.S.W., director of Citywide Focus Clinic;
   Irene Sung, M.D., chief medical officer; Alice Chen, M.D., chief medical
   officer; and Gloria Wilder, Pharm.D., director of pharmacology,
   Behavioral Health Service.
CR Druss BG, 2006, GEN HOSP PSYCHIAT, V28, P145, DOI 10.1016/j.genhosppsych.2005.10.006
   Jones N, 2019, PSYCHIAT SERV, V70, P1171, DOI 10.1176/appi.ps.201800552
   Mangurian C, 2018, COMMUNITY MENT HLT J, V54, P507, DOI 10.1007/s10597-017-0198-4
   Mangurian C, 2017, IMPLEMENT SCI, V12, DOI 10.1186/s13012-017-0663-z
   Mangurian C, 2017, PSYCHIAT SERV, V68, P990, DOI 10.1176/appi.ps.201700199
   Mangurian C, 2017, PSYCHIAT SERV, V68, P443, DOI 10.1176/appi.ps.201600248
   McGinty EE, 2021, PSYCHIAT SERV, V72, P1301, DOI 10.1176/appi.ps.202000768
   Scharf Deborah M, 2014, Rand Health Q, V4, P6
   Solmi M, 2021, AM J PSYCHIAT, V178, P793, DOI 10.1176/appi.ajp.2021.21010031
   Yonek J, 2020, JAMA PEDIATR, V174, P487, DOI 10.1001/jamapediatrics.2020.0023
NR 10
TC 7
Z9 7
U1 0
U2 0
PU AMER PSYCHIATRIC PUBLISHING, INC
PI WASHINGTON
PA 800 MAINE AVE SW, SUITE 900, WASHINGTON, DC 20024 USA
SN 1075-2730
EI 1557-9700
J9 PSYCHIAT SERV
JI Psychiatr. Serv.
PD AUG
PY 2022
VL 73
IS 8
BP 942
EP 945
DI 10.1176/appi.ps.202100177
PG 4
WC Health Policy & Services; Public, Environmental & Occupational Health;
   Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Psychiatry
GA 6M1BU
UT WOS:000888612700018
PM 35138129
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Andrade, C
AF Andrade, Chittaranjan
TI Physical Exercise and Health, 5: Sedentary Time, Independent of
   Health-Related Physical Activity, as a Risk Factor for Adverse Physical
   Health and Mental Health Outcomes
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID BEHAVIOR
AB Medical and neuropsychiatric benefits associated with physical exercise and activity are well recognized. It is less well known that time spent in sedentary behaviors, such as television -viewing or sitting at a desk, are associated with adverse health outcomes even after taking into consideration health -related physical activity. Although sedentary behaviors have become common in daily life, people tend to substantially underestimate how sedentary they actually are. The average person spends nearly 10 hours per day in a sedentary state, during leisure activities or work; sedentariness is even greater in persons with major mental illness such as psychosis. This article explains what sedentariness is, why sedentary behaviors are common in daily life, and how sedentariness is defined and assessed. Sedentariness is an important concept in its own right; it is not merely an absence of health -related physical activity. Sedentariness is associated with adverse outcomes in children and adolescents, adults, and older adults. Examples are provided of associations between sedentariness and adverse medical outcomes such as the metabolic syndrome, cardiovascular disease, stroke, and all cause mortality. Examples are also provided of associations between sedentariness and adverse mental health outcomes such as anxiety, depression, and dementia. Importantly, the adverse associations are independent of health -related physical activity; however, higher levels of physical activity may attenuate or offset the adverse effects of sedentariness. It is hoped that this article will encourage readers to reduce sedentary behaviors with a view to improve long-term physical and mental health.
C1 [Andrade, Chittaranjan] Natl Inst Mental Hlth & Neurosci, Dept Clin Psychopharmacol & Neurotoxicol, Bangalore, India.
C3 National Institute of Mental Health & Neurosciences - India
RP Andrade, C (corresponding author), Natl Inst Mental Hlth & Neurosci, Dept Clin Psychopharmacol & Neurotoxicol, Bangalore, India.
EM candrade@psychiatrist.com
CR Allen MS, 2019, J AFFECT DISORDERS, V242, P5, DOI 10.1016/j.jad.2018.08.081
   Andrade C, 2023, J CLIN PSYCHIAT, V84, DOI 10.4088/JCP.23f15110
   Andrade C, 2023, J CLIN PSYCHIAT, V84, DOI 10.4088/JCP.23f15099
   Bull FC, 2020, BRIT J SPORT MED, V54, P1451, DOI 10.1136/bjsports-2020-102955
   Chauhan JS, 2013, PLOS ONE, V8, DOI [10.1371/journal.pone.0080000, 10.1371/journal.pone.0067008]
   Ekelund U, 2020, BRIT J SPORT MED, V54, P1499, DOI 10.1136/bjsports-2020-103270
   Ekelund U, 2019, BMJ-BRIT MED J, V366, DOI 10.1136/bmj.l4570
   JETTE M, 1990, CLIN CARDIOL, V13, P555, DOI 10.1002/clc.4960130809
   Matthews CE, 2021, MED SCI SPORT EXER, V53, P2512, DOI 10.1249/MSS.0000000000002751
   Pandey A, 2016, JAMA CARDIOL, V1, P575, DOI 10.1001/jamacardio.2016.1567
   Prince SA, 2020, INT J BEHAV NUTR PHY, V17, DOI 10.1186/s12966-020-00938-3
   Raichlen DA, 2023, JAMA-J AM MED ASSOC, V330, P934, DOI 10.1001/jama.2023.15231
   Renninger M, 2020, PEDIATR OBES, V15, DOI 10.1111/ijpo.12578
   Stubbs B, 2016, SCHIZOPHR RES, V171, P103, DOI 10.1016/j.schres.2016.01.034
   Takagi H, 2019, AM J CARDIOL, V124, P1674, DOI 10.1016/j.amjcard.2019.08.032
   Wang ZT, 2022, NUTR METAB CARDIOVAS, V32, P2705, DOI 10.1016/j.numecd.2022.08.024
   Wu JJ, 2022, OBES REV, V23, DOI 10.1111/obr.13510
   Wu JJ, 2022, BMC PUBLIC HEALTH, V22, DOI 10.1186/s12889-022-12728-6
   Zhang J, 2022, J AFFECT DISORDERS, V306, P90, DOI 10.1016/j.jad.2022.03.018
   Zhou QG, 2023, J AFFECT DISORDERS, V324, P652, DOI 10.1016/j.jad.2022.12.098
NR 20
TC 4
Z9 4
U1 6
U2 17
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD MAR
PY 2024
VL 85
IS 1
AR 24f15261
DI 10.4088/JCP.24f15261
PG 4
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA RY1J1
UT WOS:001231123400007
PM 38301190
OA Bronze
DA 2025-06-11
ER

PT J
AU Zhong, YH
   Hu, MJ
   Wang, Q
   Yang, ZD
   Zhu, N
   Wang, F
   Zhang, XY
   Zhang, CF
   Min, J
   Wang, H
   Chen, FZ
   Zhao, XD
   Zhang, XY
AF Zhong, Yinghua
   Hu, Manji
   Wang, Qiang
   Yang, Zhendong
   Zhu, Na
   Wang, Fei
   Zhang, Xiyan
   Zhang, Chengfang
   Min, Jie
   Wang, Hao
   Chen, Fazhan
   Zhao, Xudong
   Zhang, Xiangyang
TI The prevalence and related factors of metabolic syndrome in outpatients
   with first-episode drug-naive major depression comorbid with anxiety
SO SCIENTIFIC REPORTS
LA English
DT Article
AB Metabolic syndrome (MetS) is associated with depression, but its role in major depressive disorder comorbid with anxiety (AMD) is unclear. This study aimed to investigate the prevalence and clinical correlates of MetS in first-episode drug-naive (FEDN) patients with AMD in a Chinese Han population. In total, 1380 FEDN outpatients with AMD were recruited in this cross-sectional study. The sociodemographic features, clinical characteristics, history of suicide attempts, thyroid-stimulating hormone (TSH) levels, and MetS parameters of each subject were evaluated. All subjects were rated on the Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A), and the Positive and Negative Syndrome Scale positive symptom subscale. The prevalence of MetS among AMD patients was 8.04%. Compared to the non-MetS group, age, age of onset, TSH level, HAM-A and HAM-D scores, history of attempted suicide, and comorbid psychiatric symptoms were higher in the MetS group. Those in this group were also more likely to be married, and they had a lower educational level. Furthermore, age, psychiatric symptoms, suicide attempts, and higher TSH levels were independently associated with MetS in AMD patients. This study suggests a lower prevalence of MetS in FEDN patients with AMD in a Chinese Han population. Older age, comorbid psychiatric symptoms, history of attempted suicide, and higher TSH levels are related factors for MetS in AMD patients.
C1 [Zhong, Yinghua; Hu, Manji; Wang, Qiang; Yang, Zhendong; Zhu, Na; Wang, Fei; Zhang, Xiyan; Zhang, Chengfang; Min, Jie; Wang, Hao; Chen, Fazhan; Zhao, Xudong] Tongji Univ, Shanghai Pudong New Area Mental Hlth Ctr, Sch Med, Shanghai, Peoples R China.
   [Zhao, Xudong] Tongji Univ, Sch Med, Div Med Humanities & Behav Sci, 1239 Siping Rd,Postbox 244, Shanghai 200092, Peoples R China.
   [Zhang, Xiangyang] Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China.
   [Zhang, Xiangyang] Univ Chinese Acad Sci, Dept Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
C3 Tongji University; Tongji University; Chinese Academy of Sciences;
   Institute of Psychology, CAS; Chinese Academy of Sciences; University of
   Chinese Academy of Sciences, CAS
RP Zhao, XD (corresponding author), Tongji Univ, Shanghai Pudong New Area Mental Hlth Ctr, Sch Med, Shanghai, Peoples R China.; Zhao, XD (corresponding author), Tongji Univ, Sch Med, Div Med Humanities & Behav Sci, 1239 Siping Rd,Postbox 244, Shanghai 200092, Peoples R China.; Zhang, XY (corresponding author), Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China.; Zhang, XY (corresponding author), Univ Chinese Acad Sci, Dept Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
EM zhaoxd@tongji.edu.cn; zhangxy@psych.ac.cn
RI Min, Jie/D-2716-2018; Zhang, Xiangyang/ABC-7380-2022; Zhao,
   Xudong/LZF-8356-2025
OI Zhang, Xiangyang/0000-0003-3326-382X; Zhao, Xudong/0000-0003-1493-3517
FU National Natural Science Foundation of China [81771464]; Training Plan
   of Health System Academic Leader of the Shanghai Pudong Municipality
   Health Commission [PWRd2019-08]; Outstanding Clinical Discipline Project
   of Shanghai Pudong [PWYgy2018-10]; Hospital Level Project of Shanghai
   Pudong New Area Mental Health Center [PDJWM201903]; General Project of
   the Shanghai Municipality Health Commission [202040475]
FX This work was supported by the National Natural Science Foundation of
   China (Grant number: 81771464), the Training Plan of Health System
   Academic Leader of the Shanghai Pudong Municipality Health Commission
   (Grant number: PWRd2019-08), the Outstanding Clinical Discipline Project
   of Shanghai Pudong (Grant number: PWYgy2018-10), the Hospital Level
   Project of Shanghai Pudong New Area Mental Health Center (Grant number:
   PDJWM201903), and the General Project of the Shanghai Municipality
   Health Commission (Grant number: 202040475).
CR Ahirwar AK, 2017, ROM J INTERN MED, V55, P212, DOI 10.1515/rjim-2017-0023
   Ahmadpanah M, 2015, INT J PSYCHIAT CLIN, V19, P168, DOI 10.3109/13651501.2015.1049277
   Akbari H, 2017, J RES MED SCI, V22, DOI 10.4103/jrms.JRMS_288_16
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Ansarimoghaddam A, 2018, DIABETES METAB SYND, V12, P195, DOI 10.1016/j.dsx.2017.11.004
   Balotsev R, 2019, EARLY INTERV PSYCHIA, V13, P101, DOI 10.1111/eip.12457
   Batelaan NM, 2016, BRIT J PSYCHIAT, V208, P223, DOI 10.1192/bjp.bp.114.156554
   Butnoriene J, 2015, INT J CARDIOL, V190, P360, DOI 10.1016/j.ijcard.2015.04.122
   Butnoriene J, 2014, PSYCHONEUROENDOCRINO, V40, P269, DOI 10.1016/j.psyneuen.2013.11.002
   Bystritsky A, 2014, ENDOCRIN METAB CLIN, V43, P269, DOI 10.1016/j.ecl.2013.10.001
   Cavicchioli FL, 2018, PSYCHIAT RES, V260, P17, DOI 10.1016/j.psychres.2017.11.024
   Chang YC, 2019, J CLIN MED, V8, DOI 10.3390/jcm8060817
   Chen QF, 2020, J DIABETES COMPLICAT, V34, DOI 10.1016/j.jdiacomp.2020.107537
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   Costemale-Lacoste JF, 2020, J AFFECT DISORDERS, V264, P513, DOI 10.1016/j.jad.2019.11.084
   de Kluiver H, 2021, WORLD J BIOL PSYCHIA, V22, P128, DOI 10.1080/15622975.2020.1761562
   Rodrigues MED, 2017, BRAIN BEHAV IMMUN, V59, P158, DOI 10.1016/j.bbi.2016.08.021
   Delanogare E, 2020, STRESS, V23, P466, DOI 10.1080/10253890.2020.1735344
   Faijer-Westerink HJ, 2020, NUTR METAB CARDIOVAS, V30, P547, DOI 10.1016/j.numecd.2019.12.012
   Gancheva S, 2017, INT J EXP PATHOL, V98, P296, DOI 10.1111/iep.12254
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Goldman-Mellor SJ, 2014, JAMA PSYCHIAT, V71, P119, DOI 10.1001/jamapsychiatry.2013.2803
   HAMILTON M, 1959, BRIT J MED PSYCHOL, V32, P50, DOI 10.1111/j.2044-8341.1959.tb00467.x
   Han KM, 2019, J AFFECT DISORDERS, V257, P486, DOI 10.1016/j.jad.2019.07.003
   Heiskanen TH, 2006, J CLIN PSYCHIAT, V67, P1422, DOI 10.4088/JCP.v67n0913
   Hiles SA, 2016, DEPRESS ANXIETY, V33, P754, DOI 10.1002/da.22512
   Hu MX, 2018, BRAIN BEHAV IMMUN, V73, P493, DOI 10.1016/j.bbi.2018.06.013
   Hung CI, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/1471-244X-14-185
   Kahl KG, 2015, BRAIN BEHAV, V5, DOI 10.1002/brb3.306
   Kahl KG, 2012, EUR ARCH PSY CLIN N, V262, P313, DOI 10.1007/s00406-011-0277-4
   KAY SR, 1987, SCHIZOPHRENIA BULL, V13, P261, DOI 10.1093/schbul/13.2.261
   Korzeniowska KA, 2019, ENDOKRYNOL POL, V70, P172, DOI 10.5603/EP.a2018.0090
   Laclaustra M, 2015, NUTR METAB CARDIOVAS, V25, P1095, DOI 10.1016/j.numecd.2015.09.007
   Li HH, 2020, J AFFECT DISORDERS, V270, P108, DOI 10.1016/j.jad.2020.03.093
   Li R, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-2870-y
   Li RC, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-58973-w
   Li YR, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0199293
   Lin CH, 2014, PSYCHIAT RES, V220, P855, DOI 10.1016/j.psychres.2014.08.048
   Mattei G, 2018, J NERV MENT DIS, V206, P316, DOI 10.1097/NMD.0000000000000807
   Michal M, 2015, INT J CARDIOL, V187, P614, DOI 10.1016/j.ijcard.2015.03.374
   Moreira FP, 2019, BRAZ J PSYCHIAT, V41, P38, DOI 10.1590/1516-4446-2017-2328
   Moreira FP, 2017, J PSYCHIATR RES, V92, P119, DOI 10.1016/j.jpsychires.2017.03.025
   Morris G, 2019, NEUROSCI BIOBEHAV R, V107, P862, DOI 10.1016/j.neubiorev.2019.09.025
   Mulvahill JS, 2017, J AM GERIATR SOC, V65, P2651, DOI 10.1111/jgs.15129
   Naicker K, 2018, DIABETOL METAB SYNDR, V10, DOI 10.1186/s13098-018-0387-5
   Nozarian Zohreh, 2017, Iran J Pathol, V12, P88
   Santos-Veloso MAO, 2019, REV ASSOC MED BRAS, V65, P801, DOI 10.1590/1806-9282.65.6.801
   Park SY, 2017, CLIN ENDOCRINOL, V87, P87, DOI 10.1111/cen.13345
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Penninx BWJH, 2017, NEUROSCI BIOBEHAV R, V74, P277, DOI 10.1016/j.neubiorev.2016.07.003
   Peter RS, 2020, DEPRESS ANXIETY, V37, P784, DOI 10.1002/da.23011
   Qin XZ, 2020, BMC PUBLIC HEALTH, V20, DOI 10.1186/s12889-020-8393-6
   Ren R, 2019, DIABETES METAB SYNDR, V12, P1563, DOI 10.2147/DMSO.S202769
   Ribeiro RP, 2015, REV LAT-AM ENFERM, V23, P435
   Richter N, 2010, EUR ARCH PSY CLIN N, V260, P41, DOI 10.1007/s00406-009-0013-5
   Shin S, 2019, APPL PHYSIOL NUTR ME, V44, P1371, DOI 10.1139/apnm-2018-0880
   Suzuki S., 2017, BAYLOR U MED CTR P, V27, P92, DOI [10.1080/08998280.2014.11929066, DOI 10.1080/08998280.2014.11929066]
   Takeuchi T, 2013, PSYCHIAT CLIN NEUROS, V67, P532, DOI 10.1111/pcn.12104
   Tang F, 2017, PSYCHONEUROENDOCRINO, V77, P112, DOI 10.1016/j.psyneuen.2016.11.025
   van Vliet-Ostaptchouk JV, 2014, BMC ENDOCR DISORD, V14, DOI 10.1186/1472-6823-14-9
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Nunes SOV, 2015, J AFFECT DISORDERS, V172, P55, DOI 10.1016/j.jad.2014.09.038
   Zhou YC, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0199209
   Zhou YJ, 2020, J AFFECT DISORDERS, V263, P500, DOI 10.1016/j.jad.2019.10.051
NR 64
TC 12
Z9 13
U1 4
U2 18
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD FEB 8
PY 2021
VL 11
IS 1
AR 3324
DI 10.1038/s41598-021-81653-2
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA QG5TA
UT WOS:000617646300009
PM 33558554
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ahles, S
   Joris, PJ
   Plat, J
AF Ahles, Sanne
   Joris, Peter J.
   Plat, Jogchum
TI Effects of Berry Anthocyanins on Cognitive Performance, Vascular
   Function and Cardiometabolic Risk Markers: A Systematic Review of
   Randomized Placebo-Controlled Intervention Studies in Humans
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE anthocyanins; cognitive performance; vascular function; cardiometabolic
   risk markers
ID DOUBLE-BLIND; BLACK-CURRANT; ENDOTHELIAL FUNCTION; BLOOD-PRESSURE;
   ARTERIAL STIFFNESS; METABOLIC SYNDROME; BLUEBERRY SUPPLEMENTATION;
   OXIDATIVE STRESS; CONTROLLED-TRIAL; OLDER-ADULTS
AB Supplementation with anthocyanins, which are a type of flavonoids mainly found in various berries, is hypothesized to be a promising approach to lower the risk of developing cognitive decline. The aim of this systematic review was to provide a comprehensive overview of dietary intervention trials describing effects of berry anthocyanins on cognitive performance in humans, while also addressing potential underlying mechanisms. A total of 1197 articles were identified through a systematic search, and 49 studies reporting effects on cognitive performance (n = 18), vascular function (n = 22), or cardiometabolic risk markers (n = 32) were included. Significant improvements were observed on memory, while some of the studies also reported effects on attention and psychomotor speed or executive function. Vascular function markers such as brachial artery flow-mediated vasodilation were also affected and consistent evidence was provided for the beneficial effects of berry anthocyanins on endothelial function. Finally, studies reported improvements in blood pressure, but effects on metabolic risk markers (e.g. carbohydrate and lipid metabolism) were less consistent. In conclusion, this review provides evidence for the beneficial effects of berry anthocyanins on cognitive performance as memory improved. Whether observed anthocyanin-induced improvements in vascular function and blood pressure underlie beneficial effects on cognitive performance warrants further study.
C1 [Ahles, Sanne; Joris, Peter J.; Plat, Jogchum] Maastricht Univ, Sch Nutr & Translat Res Metab NUTRIM, Dept Nutr & Movement Sci, NL-6200 MD Maastricht, Netherlands.
   [Ahles, Sanne] BioActor BV, Gaetano Martinolaan 85, NL-6229 GS Maastricht, Netherlands.
C3 Maastricht University
RP Plat, J (corresponding author), Maastricht Univ, Sch Nutr & Translat Res Metab NUTRIM, Dept Nutr & Movement Sci, NL-6200 MD Maastricht, Netherlands.
EM s.ahles@maastrichtuniversity.nl; p.joris@maastrichtuniversity.nl;
   j.plat@maastrichtuniversity.nl
RI Joris, Peter/AAT-8570-2021
OI Ahles, Sanne/0000-0001-8194-529X; Joris, Peter J/0000-0001-6852-5776
CR Ahles S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12082475
   Arevström L, 2019, NUTR RES, V62, P13, DOI 10.1016/j.nutres.2018.11.008
   Barfoot KL, 2019, EUR J NUTR, V58, P2911, DOI 10.1007/s00394-018-1843-6
   Basu A, 2010, J NUTR, V140, P1582, DOI 10.3945/jn.110.124701
   Boespflug EL, 2018, NUTR NEUROSCI, V21, P297, DOI 10.1080/1028415X.2017.1287833
   Bowtell JL, 2017, APPL PHYSIOL NUTR ME, V42, P773, DOI 10.1139/apnm-2016-0550
   Castro-Acosta ML, 2016, J NUTR BIOCHEM, V38, P154, DOI 10.1016/j.jnutbio.2016.09.002
   Cho JM, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-01338-z
   Clare L, 2017, PLOS MED, V14, DOI 10.1371/journal.pmed.1002259
   Cook Matthew David, 2020, Journal of Nutrition in Gerontology and Geriatrics, V39, P99, DOI 10.1080/21551197.2019.1707740
   Cook MD, 2017, NUTRIENTS, V9, DOI 10.3390/nu9060556
   Cook MD, 2017, EUR J APPL PHYSIOL, V117, P247, DOI 10.1007/s00421-016-3512-x
   Craik FIM, 2006, TRENDS COGN SCI, V10, P131, DOI 10.1016/j.tics.2006.01.007
   Creager MA, 2003, CIRCULATION, V108, P1527, DOI 10.1161/01.CIR.0000091257.27563.32
   Csipo T, 2019, GEROSCIENCE, V41, P125, DOI 10.1007/s11357-019-00063-5
   Curtis PJ, 2019, AM J CLIN NUTR, V109, P1535, DOI 10.1093/ajcn/nqy380
   Curtis PJ, 2009, J NUTR, V139, P2266, DOI 10.3945/jn.109.113126
   Daneshzad E, 2019, CLIN NUTR, V38, P1153, DOI 10.1016/j.clnu.2018.06.979
   de Menezes ST, 2021, HYPERTENSION, V77, P672, DOI 10.1161/HYPERTENSIONAHA.120.16080
   Del Bo C, 2017, FOOD FUNCT, V8, P4108, DOI 10.1039/c7fo00861a
   Del Bo' C, 2013, NUTR RES, V33, P220, DOI 10.1016/j.nutres.2012.12.009
   Erickson KI, 2019, MED SCI SPORT EXER, V51, P1242, DOI 10.1249/MSS.0000000000001936
   Fairlie-Jones L, 2017, NUTRIENTS, V9, DOI 10.3390/nu9080908
   Fang J, 2015, NUTRITION, V31, P1301, DOI 10.1016/j.nut.2015.04.015
   Flammer AJ, 2012, CIRCULATION, V126, P753, DOI 10.1161/CIRCULATIONAHA.112.093245
   Forte G, 2020, J CLIN MED, V9, DOI 10.3390/jcm9010034
   Fouda AY, 2019, ARTERIOSCL THROM VAS, V39, P593, DOI 10.1161/ATVBAHA.118.311906
   Harvey PD, 2019, DIALOGUES CLIN NEURO, V21, P227, DOI 10.31887/DCNS.2019.21.3/pharvey
   Hein S, 2019, J GERONTOL A-BIOL, V74, P984, DOI 10.1093/gerona/glz082
   Horbowicz M., 2008, Vegetable Crops Research Bulletin, V68, P5, DOI 10.2478/v10032-008-0001-8
   Istas G, 2019, AM J CLIN NUTR, V110, P316, DOI 10.1093/ajcn/nqz075
   Jeong HS, 2016, J MED FOOD, V19, P346
   Jeong HS, 2016, NUTRITION, V32, P461, DOI 10.1016/j.nut.2015.10.014
   Jeong HS, 2014, PHYTOTHER RES, V28, P1492, DOI 10.1002/ptr.5154
   Jin Y, 2011, EUR J CLIN NUTR, V65, P849, DOI 10.1038/ejcn.2011.55
   Johnson SA, 2015, J ACAD NUTR DIET, V115, P369, DOI 10.1016/j.jand.2014.11.001
   Kalt W, 2014, J AGR FOOD CHEM, V62, P3926, DOI 10.1021/jf500107j
   Kamiya Y., 2020, World Population Ageing 2020 Highlights, DOI 10.18356/9789210051934
   Kay CD, 2004, BRIT J NUTR, V91, P933, DOI 10.1079/BJN20041126
   Kent K, 2017, J HUM NUTR DIET, V30, P260, DOI 10.1111/jhn.12431
   Khan F, 2014, FREE RADICAL BIO MED, V72, P232, DOI 10.1016/j.freeradbiomed.2014.04.006
   Krikorian R, 2020, J FUNCT FOODS, V64, DOI 10.1016/j.jff.2019.103667
   Krikorian R, 2010, J AGR FOOD CHEM, V58, P3996, DOI 10.1021/jf9029332
   Loo BM, 2016, NUTR RES, V36, P1222, DOI 10.1016/j.nutres.2016.09.005
   Mattioli R, 2020, MOLECULES, V25, DOI 10.3390/molecules25173809
   Mcanulty LS, 2019, J BERRY RES, V9, P631, DOI 10.3233/JBR-190413
   McAnulty LS, 2014, NUTR RES, V34, P577, DOI 10.1016/j.nutres.2014.07.002
   McNamara RK, 2018, NEUROBIOL AGING, V64, P147, DOI 10.1016/j.neurobiolaging.2017.12.003
   Miller MG, 2018, EUR J NUTR, V57, P1169, DOI 10.1007/s00394-017-1400-8
   Murkovic M, 2004, EUR J CLIN NUTR, V58, P244, DOI 10.1038/sj.ejcn.1601773
   Murman Daniel L., 2015, Seminars in Hearing, V36, P111, DOI 10.1055/s-0035-1555115
   Nabeel PM, 2020, IEEE REV BIOMED ENG, V13, P74, DOI 10.1109/RBME.2019.2931587
   Naiberg MR, 2016, PSYCHOSOM MED, V78, P192, DOI 10.1097/PSY.0000000000000266
   Naruszewicz M, 2007, ATHEROSCLEROSIS, V194, pE179, DOI 10.1016/j.atherosclerosis.2006.12.032
   Nassour R., 2020, Journal of Chemical and Pharmaceutical Sciences, V13, P45
   Okamoto T, 2020, CLIN EXP HYPERTENS, V42, P640, DOI 10.1080/10641963.2020.1764015
   Papageorgiou N, 2012, CURR VASC PHARMACOL, V10, P94, DOI 10.2174/157016112798829788
   Pase MP, 2017, STROKE, V48, P2013, DOI 10.1161/STROKEAHA.117.013369
   Petrovic S, 2016, CAN J PHYSIOL PHARM, V94, P1058, DOI 10.1139/cjpp-2015-0575
   Pokimica B, 2019, NUTRIENTS, V11, DOI 10.3390/nu11040850
   Rahmani J, 2019, PHYTOTHER RES, V33, P1981, DOI 10.1002/ptr.6398
   Ramos P., 2014, Handbook of Anthocyanins, P373
   Recharla N, 2017, J FUNCT FOODS, V39, P63, DOI 10.1016/j.jff.2017.10.001
   Riso P, 2013, EUR J NUTR, V52, P949, DOI 10.1007/s00394-012-0402-9
   Rodriguez-Mateos A, 2014, MOL NUTR FOOD RES, V58, P1952, DOI 10.1002/mnfr.201400231
   Rodriguez-Mateos A, 2013, AM J CLIN NUTR, V98, P1179, DOI 10.3945/ajcn.113.066639
   Root-Bernstein R., 2007, Jama, V298, P2796, DOI DOI 10.1001/JAMA.298.23.2798
   Rosi A, 2019, NUTR METAB CARDIOVAS, V29, P544, DOI 10.1016/j.numecd.2019.03.003
   Segers P, 2020, ARTERIOSCL THROM VAS, V40, P1034, DOI 10.1161/ATVBAHA.119.313132
   Shi L, 2011, BRIT J NUTR, V105, P747, DOI 10.1017/S0007114510004307
   Stull AJ, 2015, NUTRIENTS, V7, P4107, DOI 10.3390/nu7064107
   Stull AJ, 2010, J NUTR, V140, P1764, DOI 10.3945/jn.110.125336
   Tomisawa T, 2019, MOLECULES, V24, DOI 10.3390/molecules24234295
   Tousoulis D, 2005, HEART, V91, P553, DOI 10.1136/hrt.2003.032847
   Traupe I, 2018, MINERVA ANESTESIOL, V84, P1352, DOI 10.23736/S0375-9393.18.12333-9
   Travica N, 2020, BRAIN BEHAV IMMUN, V85, P96, DOI 10.1016/j.bbi.2019.04.001
   Tsentidou G, 2019, J ALZHEIMERS DIS, V72, P55, DOI 10.3233/JAD-190638
   Vendemiale G, 2013, AGING CLIN EXP RES, V25, P247, DOI 10.1007/s40520-013-0043-8
   Watson AW, 2019, NUTR NEUROSCI, V22, P596, DOI 10.1080/1028415X.2017.1420539
   Whyte AR, 2017, FOOD FUNCT, V8, P4129, DOI [10.1039/C7FO00832E, 10.1039/c7fo00832e]
   Whyte AR, 2021, EUR J NUTR, V60, P1521, DOI 10.1007/s00394-020-02336-8
   Whyte AR, 2020, FOOD FUNCT, V11, P4793, DOI [10.1039/c9fo02284h, 10.1039/C9FO02284H]
   Whyte AR, 2018, NUTRIENTS, V10, DOI 10.3390/nu10060660
   Whyte AR, 2016, EUR J NUTR, V55, P2151, DOI 10.1007/s00394-015-1029-4
   Whyte AR, 2015, NUTRITION, V31, P531, DOI 10.1016/j.nut.2014.09.013
   Widmer R Jay, 2014, Glob Cardiol Sci Pract, V2014, P291, DOI 10.5339/gcsp.2014.43
   Wu XL, 2006, J AGR FOOD CHEM, V54, P4069, DOI 10.1021/jf060300l
   Xie LY, 2017, NUTR RES, V37, P67, DOI 10.1016/j.nutres.2016.12.007
NR 88
TC 32
Z9 32
U1 1
U2 24
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN
PY 2021
VL 22
IS 12
AR 6482
DI 10.3390/ijms22126482
PG 25
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA SY8JI
UT WOS:000666126900001
PM 34204250
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kontari, P
   Smith, KJ
AF Kontari, Panagiota
   Smith, Kimberley J.
TI Risk of dementia associated with cardiometabolic abnormalities and
   depressive symptoms: a longitudinal cohort study using the English
   longitudinal study of ageing
SO INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Article
DE cardiometabolic risk factors; dementia; depression
ID MILD COGNITIVE IMPAIRMENT; METABOLIC SYNDROME; ALZHEIMERS-DISEASE;
   CARDIOVASCULAR-DISEASE; POTENTIAL ROLE; LATE-LIFE; METAANALYSIS; HEALTH;
   INFLAMMATION; STATEMENT
AB Objectives: Depression and cardiometabolic abnormalities are independently associated with a high risk of dementia. This study aimed to examine the association of comorbid depressive symptoms and cardiometabolic abnormalities with risk of dementia.
   Methods: The sample comprised 4859 participants aged 50 or older without baseline dementia who took part in the English Longitudinal Study of Ageing (waves 2-7). Depressive symptoms were assessed using the Center for Epidemiologic Studies-Depression tool. Cardiometabolic abnormalities were defined as three or more cardiometabolic risk factors (inflammation, central obesity, raised triglycerides, low high-density lipoprotein [HDL] cholesterol, hypertension, and hyperglycaemia or diabetes). Participants were classified into four groups based on presence of depressive symptoms and cardiometabolic abnormalities. Results were analysed using the Cox proportional hazards regression adjusted for covariates.
   Results: A total of 216 cases of incident dementia were reported over 10 years of follow-up. The group with high depressive symptoms only had an increased hazard of developing incident dementia during follow-up (HR = 2.68; 95%CI, 1.70-4.23), which was attenuated after adjustment for baseline cognition. No evidence was found for an association of overall cardiometabolic abnormalities with incident dementia; though hyperglycaemia, hypertension, and abdominal obesity with depressive symptoms had an unadjusted association with incident dementia. Only low-HDL cholesterol with depressive symptoms had an adjusted association with incident dementia (HR = 0.18; 95%CI, 0.04-0.75).
   Conclusions: This work confirms depressive symptoms as a risk factor for incident dementia. However, low HDL-cholesterol with depressive symptoms may be protective against dementia, though more work is required to confirm this association.
C1 [Kontari, Panagiota; Smith, Kimberley J.] Univ Surrey, Sch Psychol, Fac Hlth & Med, Dept Psychol Sci, Guildford, Surrey, England.
C3 University of Surrey
RP Smith, KJ (corresponding author), Univ Surrey, Psychol Sci, Stag Hill Campus, Guildford GU2 7XH, Surrey, England.
EM kimberley.j.smith@surrey.ac.uk
RI Kontari, Panagiota/IAS-0660-2023
OI Kontari, Panagiota/0000-0002-6652-4750; Smith,
   Kimberley/0000-0002-1323-627X
CR Abell JG, 2018, EUR HEART J, V39, P3119, DOI 10.1093/eurheartj/ehy288
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Anstey KJ, 2011, OBES REV, V12, pe426, DOI 10.1111/j.1467-789X.2010.00825.x
   Assuncao N, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194990
   Beydoun MA, 2008, OBES REV, V9, P204, DOI 10.1111/j.1467-789X.2008.00473.x
   Butters Meryl A, 2008, Dialogues Clin Neurosci, V10, P345
   Calabro P, 2007, CURR CARDIOVASC RISK, V1, P32, DOI 10.1007/s12170-007-0006-8
   da Silva J, 2013, BRIT J PSYCHIAT, V202, P177, DOI 10.1192/bjp.bp.111.101931
   Fan YC, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.116.004749
   Forti P, 2010, J AM GERIATR SOC, V58, P487, DOI 10.1111/j.1532-5415.2010.02731.x
   Freitas C, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0155741
   Freitas C, 2016, INT J GERIATR PSYCH, V31, P66, DOI 10.1002/gps.4290
   Gabin JM, 2017, ALZHEIMERS RES THER, V9, DOI 10.1186/s13195-017-0262-x
   Hishikawa N, 2016, EUR J NEUROL, V23, P339, DOI 10.1111/ene.12845
   JORM AF, 1994, PSYCHOL MED, V24, P145, DOI 10.1017/S003329170002691X
   Katon W, 2015, JAMA PSYCHIAT, V72, P612, DOI 10.1001/jamapsychiatry.2015.0082
   Katon WJ, 2010, J GEN INTERN MED, V25, P423, DOI 10.1007/s11606-009-1248-6
   McIntyre Roger S, 2007, Ann Clin Psychiatry, V19, P257, DOI 10.1080/10401230701653377
   Mielke MM, 2005, NEUROLOGY, V64, P1689, DOI 10.1212/01.WNL.0000161870.78572.A5
   Muller M, 2007, DEMENT GERIATR COGN, V24, P185, DOI 10.1159/000105927
   Newman AB, 2005, J AM GERIATR SOC, V53, P1101, DOI 10.1111/j.1532-5415.2005.53360.x
   Ng TP, 2016, JAMA NEUROL, V73, P456, DOI 10.1001/jamaneurol.2015.4899
   Ownby RL, 2006, ARCH GEN PSYCHIAT, V63, P530, DOI 10.1001/archpsyc.63.5.530
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Panza F, 2011, CURR ALZHEIMER RES, V8, P492, DOI 10.2174/156720511796391818
   Park MH, 2017, INT PSYCHOGERIATR, V29, P1461, DOI 10.1017/S1041610217000965
   Pearson TA, 2003, CIRCULATION, V107, P499, DOI 10.1161/01.CIR.0000052939.59093.45
   Prince M., 2015, The epidemiology and impact of dementia. Current state and future trends
   Raffaitin C, 2009, DIABETES CARE, V32, P169, DOI 10.2337/dc08-0272
   Rasmussen KL, 2015, ANN NEUROL, V77, P301, DOI 10.1002/ana.24326
   Ríos JA, 2014, PROG NEUROBIOL, V121, P125, DOI 10.1016/j.pneurobio.2014.07.004
   Rizzi L, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/908915
   Schmitz N, 2016, MOL PSYCHIATR, V21, P1726, DOI 10.1038/mp.2016.7
   Schmitz N, 2018, BRIT J PSYCHIAT, V212, P96, DOI 10.1192/bjp.2017.26
   Schupf N, 2005, J AM GERIATR SOC, V53, P219, DOI 10.1111/j.1532-5415.2005.53106.x
   Siervo M, 2014, J ALZHEIMERS DIS, V41, P151, DOI 10.3233/JAD-132279
   Smith L, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2014-007423
   Sneed JR, 2011, AM J GERIAT PSYCHIAT, V19, P99, DOI 10.1097/JGP.0b013e318202fc8a
   Solfrizzi V, 2009, J NEUROL NEUROSUR PS
   Steptoe A, 2013, INT J EPIDEMIOL, V42, P1640, DOI 10.1093/ije/dys168
   Tang EYH, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0136181
   Vogelzangs N, 2011, J CLIN PSYCHIAT, V72, P598, DOI 10.4088/JCP.10m06559
   Watts A, 2012, ALZHEIMERS DEMENT, V8, pP496
   Wimo A, 2013, ALZHEIMERS DEMENT, V9, P1, DOI 10.1016/j.jalz.2012.11.006
NR 44
TC 15
Z9 17
U1 2
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6230
EI 1099-1166
J9 INT J GERIATR PSYCH
JI Int. J. Geriatr. Psychiatr.
PD FEB
PY 2019
VL 34
IS 2
BP 289
EP 298
DI 10.1002/gps.5019
PG 10
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA HL6BJ
UT WOS:000458818500011
PM 30370546
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Das, UN
AF Das, UN
TI A defect in the activity of Δ<SUP>6</SUP> and Δ<SUP>5</SUP> desaturases
   may be a factor predisposing to the development of insulin resistance
   syndrome
SO PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
LA English
DT Article
ID ESSENTIAL FATTY-ACIDS; TUMOR-NECROSIS-FACTOR; DEPENDENT
   DIABETES-MELLITUS; METABOLIC SYNDROME-X; ASIAN INDIAN MEN;
   CAENORHABDITIS-ELEGANS; EICOSAPENTAENOIC ACID; 3T3-L1 ADIPOCYTES;
   SKELETAL-MUSCLE; GAMMA-RADIATION
AB GLUT-4 (glucose transporter) receptor, tumor necrosis factor-alpha (TNF-alpha), interleukins-6 (IL-6), daf-genes and PPARs (peroxisomal proliferation activator receptors) play a role in the development of insulin resistance syndrome and associated conditions. But, the exact interaction between these molecules/factors and the mechanism(s) by which they produce insulin resistance syndrome is not clear.
   I propose that a defect in the activity of the enzymes Delta(6) and Delta(5) desaturases that are essential for the formation of long chain metabolites of essential fatty acids, linoleic acid and alpha-linolenic acid, is a factor in the development of insulin resistance syndrome. Long chain polyunsaturated fatty acids (LCPUFAs) increase cell membrane fluidity and enhance the number of insulin receptors and the affinity of insulin to its receptors; suppress TNF-alpha, IL-6, macrophage migration inhibitory factor (MIF) and leptin synthesis; increase the number of GLUT-4 receptors, serve as endogenous ligands of PPARs, modify lipolysis, and regulate the balance between pro- and anti-oxidants, and thus, play a critical role in the pathogenesis of insulin resistance. In the nematode, Caenorhabditis elegans, the protein encoded by daf-2 is 35% identical to the human insulin receptor; daf-7 codes a transforming growth factor-beta (TGF-beta) type signal and daf-16 enhances superoxide dismutase (SOD) expression. Melatonin has anti-oxidant actions similar to daf-16, TGF-beta and SOD. Calorie restriction enhances the activity of Delta(6) and Delta(5) desaturases, melatonin production, decreases daf-2 signaling, free radical generation, and augments anti-oxidant defenses that may explain the beneficial effect of diet control in the management of obesity, insulin resistance, and type II diabetes mellitus. These evidences suggest that the activities of Delta(6) and Delta(5) enzymes play a critical role in the expression and regulation of GLUT-4, TNF-alpha, IL-6, MIF, daf-genes, melatonin, and leptin by modulating the synthesis and tissue concentrations of LCPUFAs. Caloric restriction delays ageing by activating Sir 2 deacetylase in yeast, and expression of Sir 2 (SIRT1) in human cells. Both insulin and insulin-like growth factor-1 (IGF-1) attenuated this response. SIRT1 sequesters the proapoptotic factor Bax, prevents stress-induced apoptosis of cells, and thus, prolongs survival. In addition, SIRT1 repressed PPAR-gamma, and overexpression of SIRT1 attenuated adipogenesis, and upregulation of SIRT in differentiated fat cells triggered lipolysis and loss of fat, events that are known to attenuate insulin resistance and prolong life span. It remains to be seen whether LCPUFAs have a regulatory role in SIRT1 expression and control Sir 2 deacetylase activity. Thus, calorie restriction or reduced food intake has a role not only in the pathobiology of insulin resistance, but also in other associated conditions such as obesity, type II diabetes mellitus, ageing, and longevity. (c) 2005 Elsevier Ltd. All rights reserved.
C1 UND Life Sci, Walpole, MA 02081 USA.
RP UND Life Sci, 1083 Main St, Walpole, MA 02081 USA.
EM undurti@hotmail.com
RI Das, Undurti/A-7918-2009
CR Ashrafi K, 2003, NATURE, V421, P268, DOI 10.1038/nature01279
   Banerji MA, 1999, J CLIN ENDOCR METAB, V84, P137, DOI 10.1210/jc.84.1.137
   Bastie C, 1999, J BIOL CHEM, V274, P21920, DOI 10.1074/jbc.274.31.21920
   Camejo G, 2003, INT J CLIN PRACT, P36
   Chandalia M, 1999, J CLIN ENDOCR METAB, V84, P2329, DOI 10.1210/jc.84.7.2329
   Cohen HY, 2004, SCIENCE, V305, P390, DOI 10.1126/science.1099196
   Couzin J, 2004, SCIENCE, V304, P1731
   Das U N, 1991, J Assoc Physicians India, V39, P201
   DAS UN, 1994, MED SCI RES, V22, P243
   DAS UN, 1991, ASIA PAC J PHARMACOL, V6, P317
   DAS UN, 1991, PROSTAG LEUKOTR ESS, V44, P201, DOI 10.1016/0952-3278(91)90018-Z
   DAS UN, 1994, PROSTAG LEUKOTR ESS, V51, P207, DOI 10.1016/0952-3278(94)90136-8
   DAS UN, 1985, PROSTAG OTH LIPID M, V29, P911, DOI 10.1016/0090-6980(85)90216-3
   DAS UN, 1985, NUTR RES, V5, P101, DOI 10.1016/S0271-5317(85)80023-3
   Das UN, 2004, NUTRITION, V20, P323, DOI 10.1016/j.nut.2003.11.017
   Das UN, 2002, EXP BIOL MED, V227, P989, DOI 10.1177/153537020222701106
   Das UN, 2002, NUTRITION, V18, P774, DOI 10.1016/S0899-9007(02)00826-2
   Das UN, 2002, PROSTAG LEUKOTR ESS, V67, P1, DOI 10.1054/plef.2002.0374
   DAS UN, 1995, PROSTAG LEUKOTR ESS, V52, P387, DOI 10.1016/0952-3278(95)90066-7
   Das UN, 2001, NUTRITION, V17, P953, DOI 10.1016/S0899-9007(01)00672-4
   DAS UN, 1989, PROSTAG OTH LIPID M, V38, P689, DOI 10.1016/0090-6980(89)90050-6
   DAS UN, 1990, BIOCHEM BIOPH RES CO, V167, P1030, DOI 10.1016/0006-291X(90)90626-X
   DAS UN, 1994, PROSTAG LEUKOTR ESS, V50, P253, DOI 10.1016/0952-3278(94)90163-5
   Das UN, 1999, PROSTAG LEUKOTR ESS, V60, P13, DOI 10.1054/plef.1998.0003
   Etgen GJ, 1997, AM J PHYSIOL-ENDOC M, V272, pE864, DOI 10.1152/ajpendo.1997.272.5.E864
   Flier JS, 1998, NAT MED, V4, P1124, DOI 10.1038/2619
   Garvey WT, 1998, J CLIN INVEST, V101, P2377, DOI 10.1172/JCI1557
   GARVEY WT, 1992, DIABETES, V41, P465, DOI 10.2337/diabetes.41.4.465
   Ge YL, 2002, J NEUROCHEM, V82, P1360, DOI 10.1046/j.1471-4159.2002.01077.x
   Giannakou ME, 2004, SCIENCE, V305, P361, DOI 10.1126/science.1098219
   GOLDEN JW, 1982, SCIENCE, V218, P578, DOI 10.1126/science.6896933
   HAINAULT I, 1993, ANN NY ACAD SCI, V683, P98, DOI 10.1111/j.1749-6632.1993.tb35696.x
   Hostamisligil GS, 1999, EXP CLIN ENDOCR DIAB, V107, P119, DOI 10.1055/s-0029-1212086
   Hotamisligil GS, 1999, J INTERN MED, V245, P621, DOI 10.1046/j.1365-2796.1999.00490.x
   Hsin H, 1999, NATURE, V399, P362, DOI 10.1038/20694
   Hughes K, 1997, J EPIDEMIOL COMMUN H, V51, P394, DOI 10.1136/jech.51.4.394
   Kimura KD, 1997, SCIENCE, V277, P942, DOI 10.1126/science.277.5328.942
   Kniazeva M, 2003, GENETICS, V163, P159
   KUMAR GS, 1994, PROSTAG LEUKOTR ESS, V50, P331
   Kumar KV, 1997, P SOC EXP BIOL MED, V214, P374, DOI 10.3181/00379727-214-44106
   Lesa GM, 2003, J CELL SCI, V116, P4965, DOI 10.1242/jcs.00918
   Lonergan PE, 2004, J NEUROCHEM, V91, P20, DOI 10.1111/j.1471-4159.2004.02689.x
   Marchiafava PL, 1999, J PINEAL RES, V26, P184, DOI 10.1111/j.1600-079X.1999.tb00582.x
   Marshall BA, 1999, AM J PHYSIOL-ENDOC M, V276, pE390, DOI 10.1152/ajpendo.1999.276.2.E390
   Martin DSD, 2002, J BIOL CHEM, V277, P34239, DOI 10.1074/jbc.M205289200
   Mihaylova VT, 1999, P NATL ACAD SCI USA, V96, P7427, DOI 10.1073/pnas.96.13.7427
   Mori Y, 1997, METABOLISM, V46, P1458, DOI 10.1016/S0026-0495(97)90148-7
   Noguchi Y, 1998, BIOCHEM BIOPH RES CO, V253, P887, DOI 10.1006/bbrc.1998.9794
   Ogg S, 1997, NATURE, V389, P994, DOI 10.1038/40194
   Peyron-Caso E, 2002, HORM METAB RES, V34, P360, DOI 10.1055/s-2002-33467
   Picard F, 2004, NATURE, V429, P771, DOI 10.1038/nature02583
   Reiter RJ, 1998, ANN NY ACAD SCI, V854, P410, DOI 10.1111/j.1749-6632.1998.tb09920.x
   Rimoldi OJ, 2001, BIOCHEM BIOPH RES CO, V283, P323, DOI 10.1006/bbrc.2001.4785
   Rogina B, 2004, P NATL ACAD SCI USA, V101, P15998, DOI 10.1073/pnas.0404184101
   Rouault JP, 1999, CURR BIOL, V9, P329, DOI 10.1016/S0960-9822(99)80143-2
   Rudich A, 1997, AM J PHYSIOL-ENDOC M, V272, pE935, DOI 10.1152/ajpendo.1997.272.5.E935
   Sivitz WI, 1997, ENDOCRINOLOGY, V138, P3395, DOI 10.1210/en.138.8.3395
   Skolnik Edward Y., 1996, Cytokine and Growth Factor Reviews, V7, P161, DOI 10.1016/1359-6101(96)00021-4
   Stenbit AE, 1997, NAT MED, V3, P1096, DOI 10.1038/nm1097-1096
   Stephens JM, 1997, J BIOL CHEM, V272, P971, DOI 10.1074/jbc.272.2.971
   Suresh Y, 2003, NUTRITION, V19, P213, DOI 10.1016/S0899-9007(02)00855-9
   Suresh Y, 2003, NUTRITION, V19, P93, DOI 10.1016/S0899-9007(02)00856-0
   Suresh Y, 2001, PROSTAG LEUKOTR ESS, V64, P37, DOI 10.1054/plef.2000.0236
   Taub J, 1999, NATURE, V399, P162, DOI 10.1038/20208
   Tirosh A, 1999, J BIOL CHEM, V274, P10595, DOI 10.1074/jbc.274.15.10595
   Tissenbaum HA, 1998, GENETICS, V148, P703
   Uysal KT, 1997, NATURE, V389, P610, DOI 10.1038/39335
   Watts JL, 2002, P NATL ACAD SCI USA, V99, P5854, DOI 10.1073/pnas.092064799
   Yehuda S, 1999, J NEUROSCI RES, V56, P565, DOI 10.1002/(SICI)1097-4547(19990615)56:6<565::AID-JNR2>3.0.CO;2-H
   Zierath JB, 1997, DIABETES, V46, P215, DOI 10.2337/diabetes.46.2.215
NR 70
TC 119
Z9 130
U1 0
U2 17
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0952-3278
EI 1532-2823
J9 PROSTAG LEUKOTR ESS
JI Prostaglandins Leukot. Essent. Fatty Acids
PD MAY
PY 2005
VL 72
IS 5
BP 343
EP 350
DI 10.1016/j.plefa.2005.01.002
PG 8
WC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
GA 926CU
UT WOS:000229101200004
PM 15850715
DA 2025-06-11
ER

PT J
AU Daches, S
   Vértes, M
   Matthews, K
   Dósa, E
   Kiss, E
   Baji, I
   Kapornai, K
   George, CJ
   Kovacs, M
AF Daches, Shimrit
   Vertes, Miklos
   Matthews, Karen
   Dosa, Edit
   Kiss, Eniko
   Baji, Ildiko
   Kapornai, Krisztina
   George, Charles J.
   Kovacs, Maria
TI Metabolic syndrome among young adults at high and low familial risk for
   depression
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE depression phenotypes; early-onset; high-risk samples; metabolic
   syndrome
ID CARDIOVASCULAR-DISEASE; BIPOLAR DISORDER; MAJOR DEPRESSION; MOOD
   DISORDERS; CHILDHOOD; SYMPTOMS; ASSOCIATION; ANXIETY; METAANALYSIS;
   CHOLESTEROL
AB Background. Our study examined whether the early-onset depression phenotype among young adults (probands) is associated with the metabolic syndrome (MetS) and its components, and if MetS characterizes unaffected but high-risk siblings of probands.
   Methods. We studied three groups of young adults (Mage = 25 years, S.D. = 3.84 years): probands with histories of childhood onset depression - i.e. early-onset phenotype - (n = 293), their unaffected siblings (high-risk siblings, n = 273), and healthy controls (n = 171). Participants completed a full psychiatric interview, physical and laboratory assessments, and self-rating scales. MetS was defined using the criteria of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001).
   Results. Early-onset depression phenotype and being a high-risk sibling were associated with higher MetS composite scores relative to that of controls, but did not differ from one another. With regard to MetS components: Probands and siblings had similarly larger waist circumference and lower HDL than did controls, while siblings and controls had lower triglyceride levels than did probands but did not differ from one another. Groups did not differ on glucose levels and SBP.
   Conclusions. Our study extends the literature on the association between MetS and depression and underscores the importance of depression phenotypes: failure to account for the clinical heterogeneity of depression may partly underlie the inconsistent findings regarding its relation to MetS. The results also suggest that, in depression-prone populations, MetS may predate and possibly function as a risk factor for eventual depression.
C1 [Daches, Shimrit] Bar Ilan Univ, Dept Psychol, Ramat Gan, Israel.
   [Vertes, Miklos; Dosa, Edit] Semmelweis Univ, Heart & Vasc Ctr, Dept Intervent Radiol, Budapest, Hungary.
   [Matthews, Karen; Kovacs, Maria] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA.
   [Dosa, Edit] Hungarian Vasc Radiol Res Grp, Budapest, Hungary.
   [Kiss, Eniko; Baji, Ildiko; Kapornai, Krisztina] Univ Szeged, Dept Child & Adolescent Psychiat, Szeged, Hungary.
   [George, Charles J.] Univ Pittsburgh, Dept Psychiat, Med Ctr, Pittsburgh, PA USA.
C3 Bar Ilan University; Semmelweis University; Pennsylvania Commonwealth
   System of Higher Education (PCSHE); University of Pittsburgh; Szeged
   University; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh
RP Daches, S (corresponding author), Bar Ilan Univ, Dept Psychol, Ramat Gan, Israel.
EM shimrit.daches@biu.ac.il
RI Vertes, Miklos/AAQ-7457-2020
OI Daches, Shimrit/0000-0002-8328-4699
FU National Institute of Mental Health [R01 HL122648]
FX This study was supported by the National Institute of Mental Health
   Grant (Number: R01 HL122648).
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Akbaraly TN, 2011, DIABETES CARE, V34, P904, DOI 10.2337/dc10-1644
   Akbaraly TN, 2009, DIABETES CARE, V32, P499, DOI 10.2337/dc08-1358
   American Psychiatric Association, 2000, spectrum disorders using the current DSM-IV-TR diagnostic, V4th, DOI 10.1176/dsm10.1176/appi.books.9780890420249.dsm-iv-tr
   Avenevoli S, 2006, AM J PREV MED, V31, pS126, DOI 10.1016/j.amepre.2006.07.003
   Bakhtiari Afsaneh, 2018, Iran J Psychiatry, V13, P230
   Beck AT, 1996, San Antonio, DOI 10.1037/t00742-000
   BONDAR RJL, 1974, CLIN CHEM, V20, P586
   Borghi C, 2002, J HYPERTENS, V20, P1737, DOI 10.1097/00004872-200209000-00016
   Brailean A, 2020, PSYCHOL MED, V50, P1129, DOI 10.1017/S0033291719001004
   BUCOLO G, 1973, CLIN CHEM, V19, P476
   Carr DB, 2004, DIABETES, V53, P2087, DOI 10.2337/diabetes.53.8.2087
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   Daches S, 2019, J ABNORM CHILD PSYCH, V47, P1391, DOI 10.1007/s10802-019-00527-4
   de Frias CA, 2007, J GERONTOL B-PSYCHOL, V62, pP112, DOI 10.1093/geronb/62.2.P112
   Demirci H, 2011, KLIN PSIKOFARMAKOL B, V21, P49
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   Enko D, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0796-3
   Ervin R Bethene, 2009, Natl Health Stat Report, P1
   First M. B., 2014, ENCY CLIN PSYCHOL, P1, DOI [10.1002/9781118625392.wbecp351, DOI 10.1002/9781118625392.WBECP351]
   Foley DL, 2010, TWIN RES HUM GENET, V13, P347, DOI 10.1375/twin.13.4.347
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Gheshlagh RG, 2016, IRAN RED CRESCENT ME, V18, DOI 10.5812/ircmj.26523
   Goldstein BI, 2015, CIRCULATION, V132, P965, DOI 10.1161/CIR.0000000000000229
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Huang TL, 2004, PSYCHIAT CLIN NEUROS, V58, P295, DOI 10.1111/j.1440-1819.2004.01235.x
   Jaffee SR, 2002, ARCH GEN PSYCHIAT, V59, P215, DOI 10.1001/archpsyc.59.3.215
   Keenan-Miller D, 2007, J ADOLESCENT HEALTH, V41, P256, DOI 10.1016/j.jadohealth.2007.03.015
   Kessler RC, 2012, INT J METH PSYCH RES, V21, P169, DOI 10.1002/mpr.1359
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Kiss E, 2007, J AFFECT DISORDERS, V100, P143, DOI 10.1016/j.jad.2006.10.008
   Kovacs M, 2016, J AFFECT DISORDERS, V203, P374, DOI 10.1016/j.jad.2016.05.042
   Kovacs M, 2010, J CHILD PSYCHOL PSYC, V51, P472, DOI 10.1111/j.1469-7610.2010.02230.x
   Lasserre AM, 2017, MOL PSYCHIATR, V22, P1026, DOI 10.1038/mp.2016.178
   Lin KP, 2014, BIOL RES NURS, V16, P327, DOI 10.1177/1099800413500138
   Liu XY, 2016, ANAL BIOANAL CHEM, V408, P6497, DOI 10.1007/s00216-016-9768-5
   Mannie ZN, 2013, BRIT J PSYCHIAT, V203, P18, DOI 10.1192/bjp.bp.113.126987
   Marazziti D, 2014, CNS SPECTRUMS, V19, P293, DOI 10.1017/S1092852913000667
   MAZIADE M, 1992, AM J PSYCHIAT, V149, P1674
   McCaffery JM, 2003, PSYCHOSOM MED, V65, P490, DOI 10.1097/01.PSY.0000041545.52924.82
   McIntyre RS, 2012, INT J PSYCHIAT MED, V43, P165, DOI 10.2190/PM.43.2.e
   Moreira FP, 2017, J PSYCHIATR RES, V92, P119, DOI 10.1016/j.jpsychires.2017.03.025
   Morley JE, 2010, J ALZHEIMERS DIS, V20, P737, DOI 10.3233/JAD-2010-091576
   Muhtz C, 2009, PSYCHONEUROENDOCRINO, V34, P1004, DOI 10.1016/j.psyneuen.2009.01.016
   Padmos RC, 2009, ARCH GEN PSYCHIAT, V66, P957, DOI 10.1001/archgenpsychiatry.2009.116
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pulkki-Råback L, 2009, HEALTH PSYCHOL, V28, P108, DOI 10.1037/a0012646
   Repousi N, 2018, J AFFECT DISORDERS, V237, P56, DOI 10.1016/j.jad.2018.04.102
   Retnakaran R, 2006, J PEDIATR-US, V148, P176, DOI 10.1016/j.jpeds.2005.08.025
   Richards D, 2011, CLIN PSYCHOL REV, V31, P1117, DOI 10.1016/j.cpr.2011.07.004
   Rottenberg J, 2014, PSYCHOSOM MED, V76, P122, DOI 10.1097/PSY.0000000000000028
   Sevincok L, 2001, CAN J PSYCHIAT, V46, P68, DOI 10.1177/070674370104600110
   Shao TN, 2017, COMPR PSYCHIAT, V75, P103, DOI 10.1016/j.comppsych.2017.03.007
   Sherrill JT, 2000, J AM ACAD CHILD PSY, V39, P67, DOI 10.1097/00004583-200001000-00018
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Takeuchi T, 2009, DIABETES METAB, V35, P32, DOI 10.1016/j.diabet.2008.06.006
   Takeuchi T, 2013, PSYCHIAT CLIN NEUROS, V67, P532, DOI 10.1111/pcn.12104
   Thomas C, 2008, PEDIATRICS, V121, pE1240, DOI 10.1542/peds.2007-2403
   Tune JD, 2017, TRANSL RES, V183, P57, DOI 10.1016/j.trsl.2017.01.001
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vogelzangs N, 2011, J CLIN PSYCHIAT, V72, P598, DOI 10.4088/JCP.10m06559
   Wilson S, 2015, PSYCHOL MED, V45, P505, DOI 10.1017/S0033291714001640
   Yu SS, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-016-3913-0
   Zisook S, 2007, AM J PSYCHIAT, V164, P1539, DOI 10.1176/appi.ajp.2007.06101757
NR 67
TC 3
Z9 3
U1 2
U2 7
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD MAR
PY 2023
VL 53
IS 4
BP 1355
EP 1363
DI 10.1017/S0033291721002907
EA AUG 2021
PG 9
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA D7MY1
UT WOS:000786198400001
PM 34334146
DA 2025-06-11
ER

PT J
AU Javadi, B
   Sobhani, Z
AF Javadi, Behjat
   Sobhani, Zahra
TI Role of apigenin in targeting metabolic syndrome: A systematic review
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Review
DE Apigenin; Insulin resistance; Metabolic syndrome; Natural products;
   Obesity
ID 3T3-L1 PREADIPOCYTE DIFFERENTIATION; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; CHOLESTEROL EFFLUX; CELL-DAMAGE; PPAR-GAMMA; FLAVONOIDS;
   INFLAMMATION; MICE; PATHOPHYSIOLOGY
AB Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that has a high prevalence worldwide. Apigenin is a flavonoid present in several vegetables and fruits and has anti-inflammatory, anti -oxidant, and anti-MetS properties. This study aims to systematically review the effects of apigenin against MetS and the relevant molecular and cellular mechanisms of action, pharmacokinetics features, and potential structure -activity relationship. Electronic databases including Scopus, PubMed, Science Direct and Cochrane Library were searched for in vivo, and in vitro, and human studies with the following keywords: "apigenin" and "metabolic syndrome or insulin resistance syndrome", "fatty liver", "hypertension or blood pressure", "diabetes or blood glucose", "dyslipidemia", "heart or cardiovascular " and "obesity" in title/abstract. Data were collected from 2000 until 2021 (up to April). Only papers published in the English language were included. Forty-six full -text articles out of 1016 retrieved papers were reviewed and underwent quality assessment by investigators. Antiobesity activity of apigenin is mainly through attenuating adipocyte differentiation by suppressing the mitotic clonal expansion and the adipogenesis-related factors. Its anti -diabetic effects can be exerted through inhibition of protein tyrosine phosphatase1B expression, maintaining the activity of anti -oxidant enzymes, reducing intracellular ROS production, cellular DNA damage, protein carbonylation, and attenuating beta-cell apoptosis. Moreover, apigenin could attenuate dyslipidemia and subsequent atherosclerotic conditions through down -regulating sterol regulatory elementbinding proteins (SREBP)-1c, SREBP-2, stearyl-CoA desaturase-1, and 3-hydroxy-3-methyl-glutarylCoA reductase. Apigenin as a dietary bioactive compound would be a promising candidate for improving MetS and its components.
C1 [Javadi, Behjat; Sobhani, Zahra] Mashhad Univ Med Sci, Sch Pharm, Dept Tradit Pharm, Mashhad, Iran.
C3 Mashhad University of Medical Sciences
RP Sobhani, Z (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Tradit Pharm, Mashhad, Iran.
EM Sobhaniz@mums.ac.ir
RI Javadi, Behjat/AAC-5468-2020; sobhani, zahra/J-9573-2016
FU Research Council of Mashhad University of Medical Sciences, Iran
FX The authors would like to thank the Research Council of Mashhad
   University of Medical Sciences, Iran, for financially supporting this
   study.
CR Ali MY, 2021, COMPUT TOXICOL, V17, DOI 10.1016/j.comtox.2020.100141
   [Anonymous], HIGHL PRESCR INF
   Aranaz P, 2020, PHARMACEUTICALS-BASE, V13, DOI 10.3390/ph13110355
   Bumke-Vogt C, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0104321
   Buwa CC, 2016, CARDIOVASC TOXICOL, V16, P286, DOI 10.1007/s12012-015-9336-9
   Chen LF, 2020, J MED CHEM, V63, P13316, DOI 10.1021/acs.jmedchem.0c00884
   Cho H, 2013, VITAM HORM, V91, P405, DOI 10.1016/B978-0-12-407766-9.00017-1
   Clayton ZS, 2021, AM J PHYSIOL-HEART C, V321, pH185, DOI 10.1152/ajpheart.00118.2021
   DeRango-Adem EF, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.681477
   Ding SM, 2014, INT J NANOMED, V9, P2327, DOI 10.2147/IJN.S60938
   Paredes MD, 2018, NUTRIENTS, V10, DOI 10.3390/nu10040484
   Dostálek P, 2017, MOLECULES, V22, DOI 10.3390/molecules22101761
   Engin A, 2017, ADV EXP MED BIOL, V960, P1, DOI 10.1007/978-3-319-48382-5_1
   Escande C, 2013, DIABETES, V62, P1084, DOI 10.2337/db12-1139
   Esmaeili MA, 2009, PLANTA MED, V75, P1418, DOI 10.1055/s-0029-1185704
   Fan JF, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/479505
   Feng XJ, 2017, BIOCHEM PHARMACOL, V136, P136, DOI 10.1016/j.bcp.2017.04.014
   Feng XJ, 2016, EBIOMEDICINE, V9, P61, DOI 10.1016/j.ebiom.2016.06.017
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Fujii N, 2017, AGING CELL, V16, P508, DOI 10.1111/acel.12576
   Gao HL, 2021, CARDIOVASC TOXICOL, V21, P721, DOI 10.1007/s12012-021-09662-1
   Gentile D, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0195502
   Gradolatto A, 2005, DRUG METAB DISPOS, V33, P49, DOI 10.1124/dmd.104.000893
   Grundy SM, 2016, TRENDS CARDIOVAS MED, V26, P364, DOI 10.1016/j.tcm.2015.10.004
   Guo XX, 2016, OBES RES CLIN PRACT, V10, P327, DOI 10.1016/j.orcp.2015.08.004
   He YT, 2019, INT IMMUNOPHARMACOL, V68, P171, DOI 10.1016/j.intimp.2018.12.059
   Hong YN, 2016, EUR FOOD RES TECHNOL, V242, P1555, DOI 10.1007/s00217-016-2656-6
   Hopps E, 2010, NUTR METAB CARDIOVAS, V20, P72, DOI 10.1016/j.numecd.2009.06.002
   Hossain C. M., 2014, American Journal of Pharmacology and Toxicology, V9, P39, DOI 10.3844/ajptsp.2014.39.52
   Javadi B, 2017, CURR PHARM DESIGN, V23, P1623, DOI 10.2174/1381612822666161021143332
   Jing YX, 2019, BIOMED PHARMACOTHER, V115, DOI 10.1016/j.biopha.2019.108926
   Jung UJ, 2016, NUTRIENTS, V8, DOI 10.3390/nu8050305
   Khaafi M, 2024, MINI-REV MED CHEM, V24, P355, DOI 10.2174/1389557523666230725113446
   Kilkenny C, 2010, J PHARMACOL PHARMACO, V1, P94, DOI 10.4103/0976-500X.72351
   Kim B, 2015, EXP MOL MED, V47, DOI 10.1038/emm.2015.3
   Kim KT, 2008, FOOD SCI BIOTECHNOL, V17, P1361
   Kim MA, 2014, LIFE SCI, V101, P64, DOI 10.1016/j.lfs.2014.02.012
   Li K, 2018, CHEM CENT J, V12, DOI 10.1186/s13065-018-0445-y
   Loizzo MR, 2011, J FOOD BIOCHEM, V35, P381, DOI 10.1111/j.1745-4514.2010.00390.x
   Loizzo MR, 2007, PHYTOTHER RES, V21, P32, DOI 10.1002/ptr.2008
   Lv YA, 2019, J NUTR BIOCHEM, V71, P110, DOI 10.1016/j.jnutbio.2019.05.015
   Madunic J, 2018, CANCER LETT, V413, P11, DOI 10.1016/j.canlet.2017.10.041
   Maslov LN, 2019, J CLIN TRANSL ENDOCR, V15, P1, DOI 10.1016/j.jcte.2018.11.001
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   Meshkani R, 2009, CLIN BIOCHEM, V42, P1331, DOI 10.1016/j.clinbiochem.2009.05.018
   Myers J, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071652
   Newman DJ, 2020, J NAT PROD, V83, P770, DOI 10.1021/acs.jnatprod.9b01285
   Okla M, 2020, MOL NUTR FOOD RES, V64, DOI 10.1002/mnfr.201900925
   Ono M, 2011, J AGR FOOD CHEM, V59, P13346, DOI 10.1021/jf203490a
   Panda S, 2007, J PHARM PHARMACOL, V59, P1543, DOI 10.1211/jpp.59.11.0012
   Qin WW, 2016, VASC PHARMACOL, V85, P39, DOI 10.1016/j.vph.2016.07.006
   Rao T, 2019, PHARMACOL RES, V146, DOI 10.1016/j.phrs.2019.104283
   Rauter AP, 2010, PHYTOTHER RES, V24, pS133, DOI 10.1002/ptr.3017
   Reddy P, 2019, CLIN CHIM ACTA, V496, P35, DOI 10.1016/j.cca.2019.06.019
   Ren K, 2018, CELL PHYSIOL BIOCHEM, V47, P2170, DOI 10.1159/000491528
   Ren N, 2019, J AGR FOOD CHEM, V67, P5361, DOI 10.1021/acs.jafc.8b05348
   Roberts CK, 2013, COMPR PHYSIOL, V3, P1, DOI 10.1002/cphy.c110062
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Rodgers JT, 2008, FEBS LETT, V582, P46, DOI 10.1016/j.febslet.2007.11.034
   Russo B, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20092061
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sen K, 2019, COLLOID SURFACE B, V180, P9, DOI 10.1016/j.colsurfb.2019.04.035
   Su T, 2020, PHARMACOL RES, V152, DOI 10.1016/j.phrs.2019.104586
   Suh KS, 2012, BIOL PHARM BULL, V35, P121, DOI 10.1248/bpb.35.121
   Sui HaiXia Sui HaiXia, 2009, Journal of Environment and Health, V26, P112
   Sukandar EY, 2016, International Journal of Ayurveda and Pharma Research, V7, P82, DOI [10.7897/2277-4343.075200, DOI 10.7897/2277-4343.075200]
   Sun YS, 2019, FOOD CHEM TOXICOL, V133, DOI 10.1016/j.fct.2019.110780
   Tang D, 2017, EXPERT OPIN DRUG MET, V13, P323, DOI 10.1080/17425255.2017.1251903
   Tang L, 2012, J AGR FOOD CHEM, V60, P3223, DOI 10.1021/jf201987k
   Ulrey A, 2021, ALTEX-ALTERN ANIM EX, V38, P316, DOI 10.14573/altex.2102261
   Wan LL, 2007, J CHROMATOGR B, V855, P286, DOI 10.1016/j.jchromb.2007.05.007
   Wang F, 2017, CHEM-BIOL INTERACT, V275, P171, DOI 10.1016/j.cbi.2017.08.006
   Wang N, 2020, ADV EXP MED BIOL, V1276, P67, DOI 10.1007/978-981-15-6082-8_6
   Wang N, 2017, IN VITRO CELL DEV-AN, V53, P554, DOI 10.1007/s11626-017-0135-4
   Wong TY, 2018, J PHARM PHARMACOL, V70, P1253, DOI 10.1111/jphp.12953
   Wong TY, 2017, BIOMED PHARMACOTHER, V96, P1000, DOI 10.1016/j.biopha.2017.11.131
   Wu LL, 2021, J PHARMACOL EXP THER, V377, P146, DOI 10.1124/jpet.120.000162
   Yang M, 2018, BIOMED PHARMACOTHER, V105, P1283, DOI 10.1016/j.biopha.2018.06.108
   Yue SW, 2020, INFLAMMATION, V43, P1634, DOI 10.1007/s10753-020-01238-5
   Zafar U, 2018, HORM-INT J ENDOCRINO, V17, P299, DOI 10.1007/s42000-018-0051-3
   Zeng P, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/379538
   Zhang JJ, 2012, INT J PHARMACEUT, V436, P311, DOI 10.1016/j.ijpharm.2012.07.002
   Zhang K, 2017, EXP THER MED, V13, P1719, DOI 10.3892/etm.2017.4165
   Zhang P, 2019, EUR J PHARMACOL, V865, DOI 10.1016/j.ejphar.2019.172731
   Zhang YH, 2000, GEN PHARMACOL-VASC S, V35, P341, DOI 10.1016/S0306-3623(02)00113-1
   Zhu ZY, 2016, FOOD FUNCT, V7, P1992, DOI 10.1039/c5fo01464f
NR 86
TC 4
Z9 4
U1 1
U2 7
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD MAY
PY 2024
VL 27
IS 5
BP 524
EP 534
DI 10.22038/IJBMS.2024.71539.15558
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA KT5F6
UT WOS:001182221900013
PM 38629096
DA 2025-06-11
ER

PT J
AU Karamzad, N
   Izadi, N
   Sanaie, S
   Ahmadian, E
   Eftekhari, A
   Sullman, MJM
   Safiri, S
AF Karamzad, Nahid
   Izadi, Neda
   Sanaie, Sarvin
   Ahmadian, Elham
   Eftekhari, Aziz
   Sullman, Mark J. M.
   Safiri, Saeid
TI Asthma and metabolic syndrome: a comprehensive systematic review and
   meta-analysis of observational studies
SO JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH
LA English
DT Review
DE Metabolic Syndrome; Prevalence; Asthma; Epidemiology; Meta-analysis
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; INCIDENT ASTHMA; LUNG-FUNCTION;
   OBESITY; THERAPY; ABNORMALITIES; EPIDEMIOLOGY; INFLAMMATION; PERSPECTIVE
AB Introduction: This study aimed to perform a meta-analysis on the prevalence of metabolic syndrome (MetS) among patients with asthma and to measure the association asthma has with MetS.
   Methods: The Web of Science, Medline, Scopus, Embase and Google Scholar were searched using the "Asthma", "Metabolic Syndrome", "Dysmetabolic Syndrome", "Cardiovascular Syndrome", "Insulin Resistance Syndrome", "Prevalence", "Odds Ratio", "Cross-Sectional Studies", and "Case-Control Studies" keywords. All observational studies reporting the prevalence of MetS among people with and without asthma were included in the study. In the presence of heterogeneity, random-effects models were used to pool the prevalence and odds ratios (OR), as measures of association in cross-sectional and case-control/ cohort studies, respectively.
   Results: The prevalence of MetS among patients with asthma (8 studies) and the OR comparing the prevalence of MetS among patients with and without asthma (5 studies) were pooled separately. The pooled prevalence of MetS among patients with asthma was found to be 25% (95% confidence interval (CI): 13%-38%). In contrast, the overall pooled OR for MetS in patients with asthma, compared to healthy controls, was 1.34 (95% CI: 0.91-1.76), which was not statistically significant.
   Conclusion: The prevalence of MetS was relatively high in patients with asthma. Furthermore, the odds of MetS was higher in patients with asthma, compared to healthy controls, although this difference was not statistically significant. More original studies among different populations are needed in order to more accurately examine the association between asthma and MetS, as well as the relationship asthma has with the individual components of MetS.
C1 [Karamzad, Nahid] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran.
   [Karamzad, Nahid] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Dept Biochem & Diet Therapy, Tabriz, Iran.
   [Karamzad, Nahid] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Tabriz, Iran.
   [Izadi, Neda] Shahid Beheshti Univ Med Sci, Sch Publ Hlth & Safety, Dept Epidemiol, Student Res Comm, Tehran, Iran.
   [Sanaie, Sarvin] Tabriz Univ Med Sci, Neurosci Res Ctr, Aging Res Inst, Tabriz, Iran.
   [Ahmadian, Elham; Eftekhari, Aziz] Maragheh Univ Med Sci, Dept Basic Sci, Maragheh, Iran.
   [Sullman, Mark J. M.] Univ Nicosia, Dept Social Sci, Nicosia, Cyprus.
   [Sullman, Mark J. M.] Univ Nicosia, Dept Life & Hlth Sci, Nicosia, Cyprus.
   [Safiri, Saeid] Shahid Beheshti Univ Med Sci, Social Determinants Hlth Res Ctr, Tehran, Iran.
   [Safiri, Saeid] Tabriz Univ Med Sci, TB & Lung Dis Res Ctr, Tabriz, Iran.
   [Safiri, Saeid] Tabriz Univ Med Sci, Rahat Breath & Sleep Res Ctr, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Shahid Beheshti
   University Medical Sciences; Tabriz University of Medical Science;
   University of Nicosia; University of Nicosia; Shahid Beheshti University
   Medical Sciences; Tabriz University of Medical Science; Tabriz
   University of Medical Science
RP Safiri, S (corresponding author), Shahid Beheshti Univ Med Sci, Social Determinants Hlth Res Ctr, Tehran, Iran.; Safiri, S (corresponding author), Tabriz Univ Med Sci, TB & Lung Dis Res Ctr, Tabriz, Iran.; Safiri, S (corresponding author), Tabriz Univ Med Sci, Rahat Breath & Sleep Res Ctr, Tabriz, Iran.
EM saeidsafiri@gmail.com
RI Sanaie, Sarvin/I-3769-2016; Izadi, Neda/AIB-6552-2022; Bitaraf,
   Saeid/M-5618-2019; Ahmadian, Elham/P-8048-2017; Eftekhari,
   Aziz/O-5120-2017
OI Ahmadian, Elham/0000-0002-7230-0489; Eftekhari,
   Aziz/0000-0003-0274-4479; Izadi, Neda/0000-0002-6373-1113
FU Social Determinants of Health Research Center, Shahid Beheshti
   University of Medical Sciences, Tehran, Iran [20974]
FX The present study was supported by Social Determinants of Health
   Research Center, Shahid Beheshti University of Medical Sciences, Tehran,
   Iran (grant No. 20974).
CR Adeyeye Olufunke O, 2012, Int Arch Med, V5, P20, DOI 10.1186/1755-7682-5-20
   Agrawal A, 2011, AM J RESP CELL MOL, V44, P270, DOI 10.1165/rcmb.2010-0141TR
   Ahmed Nasir, 2016, J Ayub Med Coll Abbottabad, V28, P762
   Arron JR, 2013, ADV PHARMACOL, V66, P1, DOI 10.1016/B978-0-12-404717-4.00001-9
   Arshi M, 2010, RESPIROLOGY, V15, P779, DOI 10.1111/j.1440-1843.2010.01767.x
   Assad N, 2013, AM J RESP CRIT CARE, V188, P319, DOI 10.1164/rccm.201303-0457OC
   Aydin M, 2013, INFLAMMATION, V36, P1232, DOI 10.1007/s10753-013-9660-9
   Becker AB, 2017, CURR OPIN ALLERGY CL, V17, P99, DOI 10.1097/ACI.0000000000000346
   Beuther DA, 2006, AM J RESP CRIT CARE, V174, P112, DOI 10.1164/rccm.200602-231PP
   Beuther DA, 2007, AM J RESP CRIT CARE, V175, P661, DOI 10.1164/rccm.200611-1717OC
   Boulet LP, 2013, CLIN EXP ALLERGY, V43, P8, DOI 10.1111/j.1365-2222.2012.04040.x
   Brumpton BM, 2013, EUR RESPIR J, V42, P1495, DOI 10.1183/09031936.00046013
   Canöz M, 2008, CLIN INVEST MED, V31, pE373
   Cazzola M, 2013, CURR OPIN PULM MED, V19, P36, DOI 10.1097/MCP.0b013e32835b113a
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cottrell L, 2011, AM J RESP CRIT CARE, V183, P441, DOI 10.1164/rccm.201004-0603OC
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   Dandona P, 2014, OBESITY, V22, P356, DOI 10.1002/oby.20524
   Del-Rio-Navarro BE, 2010, J ASTHMA, V47, P501, DOI 10.3109/02770901003702808
   Demoly P, 2010, EUR RESPIR REV, V19, P150, DOI 10.1183/09059180.00002110
   Dut R, 2008, ALLERGY, V63, P1605, DOI 10.1111/j.1398-9995.2008.01766.x
   Egger M, 1997, BMJ-BRIT MED J, V315, P629, DOI 10.1136/bmj.315.7109.629
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   Ford ES, 2005, J ALLERGY CLIN IMMUN, V115, P897, DOI 10.1016/j.jaci.2004.11.050
   Forno E, 2015, J ALLERGY CLIN IMMUN, V136, P304, DOI 10.1016/j.jaci.2015.01.010
   Garcia G, 2013, EUR RESPIR REV, V22, P251, DOI 10.1183/09059180.00004013
   Gershon AS, 2010, THORAX, V65, P612, DOI 10.1136/thx.2009.131078
   Huang CC, 2011, EUR J CLIN INVEST, V41, P507, DOI 10.1111/j.1365-2362.2010.02434.x
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Kuschnir FC, 2018, J ALLERGY CLIN IMMUN, V141, P1947, DOI 10.1016/j.jaci.2018.01.026
   Lazarus R, 1998, AM J CLIN NUTR, V68, P35, DOI 10.1093/ajcn/68.1.35
   Lee EJ, 2009, J ASTHMA, V46, P339, DOI 10.1080/02770900802660931
   Leone N, 2012, OBESITY, V20, P628, DOI 10.1038/oby.2011.308
   Linderholm AL, 2014, IMMUNOL ALLERGY CLIN, V34, P809, DOI 10.1016/j.iac.2014.07.006
   Lugogo NL, 2011, BBA-GEN SUBJECTS, V1810, P1120, DOI 10.1016/j.bbagen.2011.09.004
   Lugogo NL, 2010, J APPL PHYSIOL, V108, P729, DOI 10.1152/japplphysiol.00845.2009
   Malagón MM, 2013, CURR VASC PHARMACOL, V11, P954, DOI 10.2174/15701611113116660170
   Maneechotesuwan K, 2010, J ALLERGY CLIN IMMUN, V126, P754, DOI 10.1016/j.jaci.2010.08.005
   McGinley B, 2011, AM J RESP CRIT CARE, V183, P424, DOI 10.1164/rccm.201009-1525ED
   Mcilroy GD, 2013, DIABETES, V62, P825, DOI 10.2337/db12-0458
   Modesti PA, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0147601
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Moini A, 2012, ALLERGY ASTHMA IMMUN, V4, P290, DOI 10.4168/aair.2012.4.5.290
   National Asthma Education and Prevention Program, 2007, J Allergy Clin Immunol, V120, pS94
   Ogden CL, 2014, JAMA-J AM MED ASSOC, V311, P806, DOI 10.1001/jama.2014.732
   Ota T, 2013, DIABETES METAB J, V37, P165
   Pantoja-Alcantar Juan Manuel, 2012, Rev Alerg Mex, V59, P3
   Park J, 2013, ALLERGY ASTHMA IMMUN, V5, P16, DOI 10.4168/aair.2013.5.1.16
   Reddel HK, 2014, INT J TUBERC LUNG D, V18, P505, DOI 10.5588/ijtld.14.0246
   Sasaki O, 2013, J IMMUNOL, V191, P2879, DOI 10.4049/jimmunol.1300460
   Si XB, 2013, J INT MED RES, V41, P276, DOI 10.1177/0300060513477005
   Silva D, 2012, J ASTHMA, V49, P885, DOI 10.3109/02770903.2012.721433
   Singh Mandeep, 2016, Pneumonol Alergol Pol, V84, P258, DOI 10.5603/PiAP.2016.0032
   Sovio U, 2013, J OBES, V2013, DOI 10.1155/2013/684782
   Steffes MW, 2006, OBESITY, V14, P319, DOI 10.1038/oby.2006.41
   Thuesen BH, 2009, CLIN EXP ALLERGY, V39, P700, DOI 10.1111/j.1365-2222.2008.03197.x
   Tsuchiya H, 2012, HEPATOLOGY, V56, P1319, DOI 10.1002/hep.25798
   Ulrik CS, 2009, CLIN RESPIR J, V3, P161, DOI 10.1111/j.1752-699X.2009.00129.x
   Uzunlulu M, 2011, ACTA CLIN BELG, V66, P49, DOI 10.1179/ACB.66.1.2062514
   von Elm E, 2007, PLOS MED, V4, P1623, DOI [10.1371/journal.pmed.0040296, 10.1371/journal.pmed.0040297, 10.1016/S0140-6736(07)61602-X]
   Weiss ST, 2004, AM J RESP CRIT CARE, V169, P963, DOI 10.1164/rccm.200303-403WS
   Yuan C, 2012, RESP RES, V13, DOI 10.1186/1465-9921-13-108
   Zeki Amir A, 2011, Drug Metab Lett, V5, P40
NR 63
TC 16
Z9 17
U1 1
U2 4
PU TABRIZ UNIV MEDICAL SCIENCES & HEALTH SERVICES
PI TABRIZ
PA DANESHGHAH ST, TABRIZ, REPUBLIC ISLAMIC 51664-14766, IRAN
SN 2008-5117
EI 2008-6830
J9 J CARDIOVASC THORAC
JI J. Cardiovasc. Thorac. Res.
PY 2020
VL 12
IS 2
BP 120
EP 128
DI 10.34172/jcvtr.2020.20
PG 9
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA LY1XL
UT WOS:000540314600007
PM 32626552
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lipovac, M
   Chedraui, P
   Gruenhut, C
   Gocan, A
   Stammler, M
   Imhof, M
AF Lipovac, Markus
   Chedraui, Peter
   Gruenhut, Christine
   Gocan, Ana
   Stammler, Maria
   Imhof, Martin
TI Improvement of postmenopausal depressive and anxiety symptoms after
   treatment with isoflavones derived from red clover extracts
SO MATURITAS
LA English
DT Article
DE Depressive mood; Anxiety; Postmenopause; Red clover; Isoflavones
ID DIETARY SOY PHYTOESTROGENS; HUMAN ENDOTHELIAL-CELLS; MENOPAUSE
   RATING-SCALE; MIDLIFE WOMENS HEALTH; MIDDLE-AGED WOMEN; QUALITY-OF-LIFE;
   TRIFOLIUM-PRATENSE; ESTROGENIC ACTIVITY; METABOLIC SYNDROME;
   HORMONE-THERAPY
AB Objective: To evaluate the effect of isoflavones derived from red clover extracts (MF11RCE) over anxiety and depressive symptoms among postmenopausal women.
   Methods: One hundred and nine postmenopausal women aged 40 or more were randomly assigned to receive two daily capsules of MF11RCE (80 mg red clover isoflavones, Group A) or placebo of equal appearance (Group B) for a 90-day period. After a washout period of 7 days, medication was crossed over and taken for 90 days more. Anxiety and depressive symptoms were measured at baseline, 90 and 187 days with the Hospital Anxiety and Depression Scale (HADS) and Zung's Self Rating Depression Scale (SDS).
   Results: After receiving the MF11RCE compound the total HADS (anxiety and depression subscale scores also) and the total SDS scores decreased significantly. This effect was equivalent to a 76.9% reduction in the total HADS score (76% for anxiety and 78.3% for depression) and an 80.6% reduction in the total SDS score. After placebo, total HADS (anxiety and depression subscale also) and total SDS scores also decreased significantly in comparison to baseline but only equivalent to an average 21.7% decline.
   Conclusion: Red clover derived isoflavones (MF11RCE) were effective in reducing depressive and anxiety symptoms among postmenopausal women. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
C1 [Chedraui, Peter] Inst Salud Mujer, Guayaquil, Ecuador.
   [Lipovac, Markus; Imhof, Martin] Gen Teaching Hosp Korneuburg, Div Obstet & Gynecol, Korneuburg, Austria.
   [Gruenhut, Christine; Gocan, Ana] Study Ctr Med XIX, A-1190 Vienna, Austria.
   [Stammler, Maria] Med Univ Vienna, Div Obstet & Gynecol, Vienna, Austria.
C3 Medical University of Vienna
RP Chedraui, P (corresponding author), Inst Salud Mujer, Velez 616 & Garcia Aviles,POB 09-02000-70-A, Guayaquil, Ecuador.
EM institutochedraui@gmail.com
RI Blümel, Juan Enrique/JUV-6950-2023
FU Melbrosin International, Produktions and Vertriebs GmbH & Co KG, Vienna,
   Austria
FX This study was supported by Melbrosin International, Produktions and
   Vertriebs GmbH & Co KG, Vienna, Austria and presented as a free
   communication at the 12th World Congress on the Menopause, Madrid-Spain,
   May 19-23, 2008.
CR ADAIKAN PG, 2008, FERTIL STER IN PRESS
   Albert A, 2002, PHYTOMEDICINE, V9, P85, DOI 10.1078/0944-7113-00107
   Amick BC, 1998, SCAND J WORK ENV HEA, V24, P54, DOI 10.5271/sjweh.278
   Barry K L, 1998, Fam Med, V30, P366
   Bhavnani BR, 2005, J OBSTET GYNAECOL CA, V27, P137, DOI 10.1016/S1701-2163(16)30186-4
   Blümel JE, 2004, MENOPAUSE, V11, P57, DOI 10.1097/01.GME.0000075503.60230.61
   Bodo C, 2006, FRONT NEUROENDOCRIN, V27, P217, DOI 10.1016/j.yfrne.2006.02.004
   Bu LH, 2005, NEUROSCI LETT, V385, P153, DOI 10.1016/j.neulet.2005.05.040
   Caspi A, 2003, SCIENCE, V301, P386, DOI 10.1126/science.1083968
   Castelo-Branco C, 2006, Minerva Ginecol, V58, P137
   Chedraui P, 2006, INT J GYNECOL OBSTET, V95, P296, DOI 10.1016/j.ijgo.2006.08.013
   Chedraui P., 2007, Archives of Gynecology and Obstetrics, V275, P161, DOI 10.1007/s00404-006-0239-7
   CHEDRAUI P, 2008, CLIMACTERIC, V11, P125
   Chedraui P, 2007, MATURITAS, V57, P271, DOI 10.1016/j.maturitas.2007.01.009
   Chedraui P, 2008, GYNECOL ENDOCRINOL, V24, P620, DOI 10.1080/09513590802288283
   Chedraui P, 2009, GYNECOL ENDOCRINOL, V25, P130, DOI 10.1080/09513590802617770
   Chedraui P, 2008, MATURITAS, V61, P323, DOI 10.1016/j.maturitas.2008.09.026
   Chen HQ, 2008, NEUROSCI RES, V62, P123, DOI 10.1016/j.neures.2008.07.001
   Coon JT, 2007, PHYTOMEDICINE, V14, P153, DOI 10.1016/j.phymed.2006.12.009
   Craig MC, 2007, CLIMACTERIC, V10, P97, DOI 10.1080/13697130701598746
   Dornstauder E, 2001, J STEROID BIOCHEM, V78, P67, DOI 10.1016/S0960-0760(01)00075-9
   Ettinger B, 2003, OBSTET GYNECOL, V102, P1225, DOI 10.1016/j.obstetgynecol.2003.08.007
   Freeman EW, 2005, MENOPAUSE, V12, P258, DOI 10.1097/01.GME.0000142440.49698.B7
   Hidalgo LA, 2005, GYNECOL ENDOCRINOL, V21, P257, DOI 10.1080/09513590500361192
   Imhof M, 2006, MATURITAS, V55, P76, DOI 10.1016/j.maturitas.2006.01.006
   Joffe H, 2002, MENOPAUSE, V9, P392, DOI 10.1097/00042192-200211000-00003
   Juang KD, 2005, MATURITAS, V52, P119, DOI 10.1016/j.maturitas.2005.01.005
   KESSLER RC, 1993, J AFFECT DISORDERS, V29, P85, DOI 10.1016/0165-0327(93)90026-G
   KOUZIS AC, 1994, AM J PUBLIC HEALTH, V84, P1304, DOI 10.2105/AJPH.84.8.1304
   Lazar F, 2007, MATURITAS, V56, P129, DOI 10.1016/j.maturitas.2006.06.022
   Lephart ED, 2004, ILAR J, V45, P443, DOI 10.1093/ilar.45.4.443
   Lephart ED, 2002, NEUROTOXICOL TERATOL, V24, P5, DOI 10.1016/S0892-0362(01)00197-0
   Lund TD, 2001, BRAIN RES, V913, P180, DOI 10.1016/S0006-8993(01)02793-7
   MIKSICEK RJ, 1993, MOL PHARMACOL, V44, P37
   MIKSICEK RJ, 1994, J STEROID BIOCHEM, V49, P153, DOI 10.1016/0960-0760(94)90005-1
   Monterrosa A, 2008, MATURITAS, V59, P182, DOI 10.1016/j.maturitas.2007.12.002
   Mueller M, 2008, MENOPAUSE, V15, P1120, DOI 10.1097/gme.0b013e31817062ce
   Nassar AH, 2005, MATURITAS, V52, P18, DOI 10.1016/j.maturitas.2005.03.008
   Occhiuto F, 2009, PHYTOTHER RES, V23, P192, DOI 10.1002/ptr.2584
   Occhiuto F, 2008, PHYTOMEDICINE, V15, P676, DOI 10.1016/j.phymed.2008.04.007
   Rossouw JE, 2002, JAMA-J AM MED ASSOC, V288, P321, DOI 10.1001/jama.288.3.321
   Schmidt P J, 2004, Arch Womens Ment Health, V7, P19, DOI 10.1007/s00737-003-0036-2
   Sierra B, 2005, MATURITAS, V51, P236, DOI 10.1016/j.maturitas.2004.08.003
   Simoncini T, 2005, MENOPAUSE, V12, P69, DOI 10.1097/00042192-200512010-00013
   Simoncini T, 2008, MENOPAUSE, V15, P542, DOI 10.1097/gme.0b013e318156f9d6
   Szoeke CE, 2008, CLIMACTERIC, V11, P55, DOI 10.1080/13697130701746006
   WELLS KB, 1989, JAMA-J AM MED ASSOC, V262, P914, DOI 10.1001/jama.262.7.914
   Woods NF, 2006, CLIMACTERIC, V9, P195, DOI 10.1080/13697130600730663
   Woods NF, 2008, MENOPAUSE, V15, P223, DOI 10.1097/gme.0b013e3181450fc2
   Woods NF, 2002, ACTA OBSTET GYN SCAN, V81, P623, DOI 10.1034/j.1600-0412.2002.810708.x
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
   ZUNG WWK, 1965, ARCH GEN PSYCHIAT, V12, P63, DOI 10.1001/archpsyc.1965.01720310065008
NR 52
TC 49
Z9 53
U1 2
U2 22
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD MAR
PY 2010
VL 65
IS 3
BP 258
EP 261
DI 10.1016/j.maturitas.2009.10.014
PG 4
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA 574MG
UT WOS:000275992900014
PM 19948385
DA 2025-06-11
ER

PT J
AU Schlotz, W
   Ambery, P
   Syddall, HE
   Crozier, SR
   Sayer, AA
   Cooper, C
   Phillips, DIW
AF Schlotz, Wolff
   Ambery, Phil
   Syddall, Holly E.
   Crozier, Sarah R.
   Sayer, Avan Aihie
   Cooper, Cyrus
   Phillips, David I. W.
CA Hertfordshire Cohort Study Grp
TI Specific associations of insulin resistance with impaired health-related
   quality of life in the Hertfordshire Cohort Study
SO QUALITY OF LIFE RESEARCH
LA English
DT Article
DE insulin resistance; HOMA-IR; health-related quality of life; physical
   functioning; SF-36; subjective health
ID BETA-CELL FUNCTION; SURVEY QUESTIONNAIRE; COMORBID DEPRESSION; ANXIETY
   DISORDERS; GLUCOSE-UPTAKE; WHITEHALL-II; SF-36; PREVALENCE; WEIGHT; HOMA
AB Insulin resistance is a metabolic abnormality that underlies Type 2 diabetes, the metabolic syndrome and cardiovascular disease, but it may also be associated with more global health deficits. This study assessed associations of insulin resistance with health-related quality of life (HRQoL) in different domains of physical and mental health in a large elderly population study. Cross-sectional data of 1212 participants from the Hertfordshire Cohort Study were analysed. Insulin resistance was assessed by the homeostatic model assessment (HOMA-IR), and HRQoL was measured using the SF-36 health survey. Poor HRQoL was defined by a score lower than the sex-specific 10th percentile of each scale, and logistic regressions yielded odds ratios in relation to the HOMA-IR scores. Subsequent analyses adjusted for the influence of age, smoking, alcohol consumption, social class, BMI, coronary heart disease and depression. Results showed an increase in poor HRQoL with an increase in HOMA-IR scores for physical functioning (OR = 2.29; CI: 1.67-3.13), vitality (OR = 1.45; CI: 1.05-2.00), and general health (OR = 1.62; CI: 1.19-2.21). In men, but not in women, associations with physical functioning were independent of confounding variables. The results indicate that insulin resistance is associated with poor HRQoL in domains of physical health, but not in domains of mental health.
C1 Univ Southampton, MRC, Epidemiol Resource Ctr, Southampton Gen Hosp, Southampton SO16 6YD, Hants, England.
C3 University of Southampton
RP Schlotz, W (corresponding author), Univ Southampton, MRC, Epidemiol Resource Ctr, Southampton Gen Hosp, Southampton SO16 6YD, Hants, England.
EM ws@mrc.soton.ac.uk
RI Cooper, Cyrus/ADV-7232-2022; Schlotz, Wolff/AAI-9549-2020; Sayer,
   Avan/A-4359-2012
OI Cooper, Cyrus/0000-0003-3510-0709; Crozier, Sarah/0000-0002-9524-1127;
   Syddall, Holly/0000-0003-0171-0306; Schlotz, Wolff/0000-0003-2356-7766;
   Aihie Sayer, Avan/0000-0003-1283-6457
FU Medical Research Council [MC_U147574213, MC_U147585824, MC_UP_A620_1014,
   U.1475.00.002.00001.01(74213)] Funding Source: Medline
CR Abbatecola AM, 2004, J AM GERIATR SOC, V52, P1713, DOI 10.1111/j.1532-5415.2004.52466.x
   Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   [Anonymous], 2000, Qual. Life Res.
   Bowling A, 1999, J PUBLIC HEALTH MED, V21, P255, DOI 10.1093/pubmed/21.3.255
   Dixon JB, 2003, DIABETIC MED, V20, P127, DOI 10.1046/j.1464-5491.2003.00889.x
   Doll HA, 2000, OBES RES, V8, P160, DOI 10.1038/oby.2000.17
   Egede LE, 2002, DIABETES CARE, V25, P464, DOI 10.2337/diacare.25.3.464
   Everson-Rose SA, 2004, DIABETES CARE, V27, P2856, DOI 10.2337/diacare.27.12.2856
   FALL CHD, 1995, BRIT MED J, V310, P17, DOI 10.1136/bmj.310.6971.17
   GARRATT AM, 1993, BMJ-BRIT MED J, V306, P1440, DOI 10.1136/bmj.306.6890.1440
   Geroldi C, 2005, ARCH NEUROL-CHICAGO, V62, P1067, DOI 10.1001/archneur.62.7.1067
   Hällsten K, 2004, DIABETIC MED, V21, P1280, DOI 10.1111/j.1464-5491.2004.01332.x
   Hällsten K, 2002, DIABETES, V51, P3479, DOI 10.2337/diabetes.51.12.3479
   HAYES V, 1995, AGE AGEING, V24, P120, DOI 10.1093/ageing/24.2.120
   Hermanns N, 2005, DIABETIC MED, V22, P293, DOI 10.1111/j.1464-5491.2005.01414.x
   KALMIJN S, 1995, DIABETOLOGIA, V38, P1096, DOI 10.1007/s001250050397
   Kumari M, 2004, ANN EPIDEMIOL, V14, P250, DOI 10.1016/j.annepidem.2003.09.011
   Lawlor DA, 2003, BRIT MED J, V327, P1383, DOI 10.1136/bmj.327.7428.1383
   LYONS RA, 1994, J EPIDEMIOL COMMUN H, V48, P388, DOI 10.1136/jech.48.4.388
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Pereira MA, 2005, LANCET, V365, P36, DOI 10.1016/S0140-6736(04)17663-0
   Regensteiner JG, 2005, DIABETES CARE, V28, P2877, DOI 10.2337/diacare.28.12.2877
   Sayer AA, 2005, DIABETES CARE, V28, P2541, DOI 10.2337/diacare.28.10.2541
   Silveira E, 2005, QUAL LIFE RES, V14, P1263, DOI 10.1007/s11136-004-7753-5
   Stafford M, 1998, J EPIDEMIOL COMMUN H, V52, P353, DOI 10.1136/jech.52.6.353
   Syddall HE, 2005, INT J EPIDEMIOL, V34, P1234, DOI 10.1093/ije/dyi127
   Ugur-Altun B, 2004, J ENDOCRINOL INVEST, V27, P455, DOI 10.1007/BF03345291
   van der Waal JM, 2005, QUAL LIFE RES, V14, P1141, DOI 10.1007/s11136-004-4599-9
   Wallace TM, 2004, DIABETES CARE, V27, P1487, DOI 10.2337/diacare.27.6.1487
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 30
TC 34
Z9 35
U1 0
U2 4
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-9343
EI 1573-2649
J9 QUAL LIFE RES
JI Qual. Life Res.
PD APR
PY 2007
VL 16
IS 3
BP 429
EP 436
DI 10.1007/s11136-006-9129-5
PG 8
WC Health Care Sciences & Services; Health Policy & Services; Public,
   Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA 143AQ
UT WOS:000244692800006
PM 17091361
DA 2025-06-11
ER

PT J
AU Porter, C
   Aggar, C
AF Porter, Cassandra
   Aggar, Christina
TI A practical toolkit to support Australian mental health clinicians to
   manage Metabolic Syndrome: A pilot study
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE mental health; metabolic syndrome; physical health; screening; severe
   mental illness; staff development
ID PHYSICAL HEALTH; NURSES ATTITUDES; PEOPLE; CARE; ILLNESS; DISORDERS;
   NEEDS
AB Metabolic syndrome (MetS) results in poor physical health outcomes and reduced life expectancy of up to 20 years less for people living with severe mental illness. The aim of this pilot study was to evaluate a locally developed practical toolkit (Let's Get Physical-Improved Physical Health in Mental Health Services-A Practical Toolkit) to support mental health clinicians to manage MetS. The study explored clinician's knowledge and attitudes towards managing MetS, confidence to screen for and intervene in MetS, and improvement in documentation. A longitudinal prospective study, utilizing audit and pre-post-questionnaire design, was conducted. Of the 60 clinicians who were employed in the regional inpatient unit, 65% (n = 39) participated in at least one of the intervention education sessions. The final sample comprised 17 clinicians with matched pre- and post-intervention data (28% of eligible participants). A total of 80 (20 per month) eMR metabolic monitoring form and patient file audits were conducted. Whilst the results were not statistically significant, this study found an overall improvement in clinicians' knowledge of, and confidence to screen for and intervene in, MetS. Attitude scores were overall positive. There was also overall improvement in MetS documentation. The implementation of the practical evidence-informed physical health in mental health services toolkit may have a positive impact on clinician knowledge, attitudes, and confidence in screening and intervening in MetS. Replicating this study with a larger sample is recommended.
C1 [Porter, Cassandra] Northern NSW Local Hlth Dist, Mental Hlth Serv, 16 Powell St, Tweed Heads, NSW 2485, Australia.
   [Aggar, Christina] Southern Cross Univ, Sch Hlth & Human Sci, Lismore, NSW, Australia.
   [Aggar, Christina] Northern NSW Local Hlth Dist, Nursing & Midwifery Directorate, Lismore, NSW, Australia.
C3 Southern Cross University
RP Porter, C (corresponding author), Northern NSW Local Hlth Dist, Mental Hlth Serv, 16 Powell St, Tweed Heads, NSW 2485, Australia.
EM Cassandra.porter@health.nsw.-gov.au
RI Aggar, Christina/ABD-7762-2021
OI Aggar, Christina/0000-0002-0137-7796; Tognarini,
   Cassandra/0000-0002-7224-8393
FU Northern NSW Local Health District Mental Health Services
FX This research was funded by Northern NSW Local Health District Mental
   Health Services. The funders were not involved in the study design, data
   collection, data analysis and interpretation, or writing of the
   manuscript. The funders were involved in the decision to submit this
   article for publication.
CR [Anonymous], 2014, Australias physical activity and sedentary behaviour guidelines
   Bardi J., 2016, Primary Health Care, V26, P28, DOI [10.7748/phc.2016.e1149, DOI 10.7748/PHC.2016.E1149]
   Bolton PS, 2016, J PSYCHOSOC NURS MEN, V54, P44, DOI 10.3928/02793695-20161026-01
   Damschroder LJ, 2009, IMPLEMENT SCI, V4, DOI 10.1186/1748-5908-4-50
   Firth J, 2019, LANCET PSYCHIAT, V6, P675, DOI 10.1016/S2215-0366(19)30132-4
   Galletly C, 2016, AUST NZ J PSYCHIAT, V50, P410, DOI 10.1177/0004867416641195
   Galletly CA, 2012, AUST NZ J PSYCHIAT, V46, P753, DOI 10.1177/0004867412453089
   Gray R, 2017, INT J MENT HEALTH NU, V26, P32, DOI 10.1111/inm.12296
   Happell B, 2019, J INTERPROF CARE, V33, P226, DOI 10.1080/13561820.2018.1516201
   Happell B, 2013, J CLIN NURS, V22, P2286, DOI 10.1111/j.1365-2702.2012.04325.x
   Hennessy S, 2018, ISSUES MENT HEALTH N, V39, P700, DOI 10.1080/01612840.2018.1429509
   Howard L, 2011, J PSYCHIATR MENT HLT, V18, P105, DOI 10.1111/j.1365-2850.2010.01642.x
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Kaur J., 2014, Medical Sciences, V2, P140, DOI DOI 10.3390/MEDSCI2030140
   Lawrence David, 2013, BMJ, V346, pf2539, DOI 10.1136/bmj.f2539
   Li JYZ, 2013, J EVAL CLIN PRACT, V19, P76, DOI 10.1111/j.1365-2753.2011.01772.x
   National Health and Medical Research Council, 2013, AUSTR DIET GUID
   New South Wales Department of Health, 2017, PHYS HLTH CAR MENT H
   New South Wales Department of Health, 2015, MAN NIC DEP GUID NSW
   Paley CA, 2018, BMC SPORTS SCI MED R, V10, DOI 10.1186/s13102-018-0097-1
   Robson D, 2013, INT J MENT HEALTH NU, V22, P409, DOI 10.1111/j.1447-0349.2012.00883.x
   Robson D, 2012, INT J NURS STUD, V49, P72, DOI 10.1016/j.ijnurstu.2011.07.011
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Samaras K, 2010, EARLY INTERVENTION P, V4
   Senior T, 2012, NATL GUIDE PREVENTIV
   Stewart R, 2015, ACTA PSYCHIAT SCAND, V132, P410, DOI 10.1111/acps.12476
NR 26
TC 1
Z9 1
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD OCT
PY 2021
VL 30
SU 1
BP 1417
EP 1425
DI 10.1111/inm.12899
EA JUN 2021
PG 9
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA UN1NP
UT WOS:000660418800001
PM 34117825
DA 2025-06-11
ER

PT J
AU Wu, B
   Huang, JS
   Fukuo, K
   Suzuki, K
   Yoshino, G
   Kazumi, T
AF Wu, Bin
   Huang, Jingshan
   Fukuo, Keisuke
   Suzuki, Kazuhisa
   Yoshino, Gen
   Kazumi, Tsutomu
TI Different Associations of Trunk and Lower-Body Fat Mass Distribution
   with Cardiometabolic Risk Factors between Healthy Middle-Aged Men and
   Women
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID DENSITY-LIPOPROTEIN CHOLESTEROL; INTIMA-MEDIA THICKNESS; X-RAY
   ABSORPTIOMETRY; INSULIN SENSITIVITY; ABDOMINAL FAT; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; WAIST CIRCUMFERENCE; PLASMA; INDEX
AB The aim of this study was to assess whether the gender-specific pattern of fat mass (FM) distribution is related to gender differences in cardiometabolic risk factors. 207 healthy middle-aged Japanese were included in the study. We measured FM in the total body, trunk, and lower-body with dual-energy X-ray absorptiometry (DXA). The percentage of trunk FM (TFM) and lower-body FM (LFM) is noted as % TFM and % LFM, respectively. Other measurements included glucose and insulin during oral glucose tolerance test (OGTT), leptin, adiponectin, plasminogen activator inhibitor-1 (PAI-1), tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and systemic oxidative stress marker. Arterial properties were indicated by cardio-ankle vascular index (CAVI) and intima-media thickness (IMT) of the common carotid artery. The results showed that % TFM is higher whereas % LFM is lower in men than in women and men have a more atherogenic cardiometabolic profile. In both genders, % TFM (% LFM) is related to an unfavorable (favorable) cardiometabolic profile. In particular, the relation between % LFM and OGTT-derived insulin sensitivity index is stronger in women than in men. These findings suggested that in relatively healthy adults, android and gynoid pattern of FM distribution contributes to gender differences in cardiometabolic risk factors.
C1 [Wu, Bin; Fukuo, Keisuke; Suzuki, Kazuhisa; Kazumi, Tsutomu] Mukogawa Womens Univ, Open Res Ctr Studying Lifestyle Related Dis, 6-46 Ikebiraki Cho, Nishinomiya, Hyogo 6638558, Japan.
   [Wu, Bin] Kunming Med Univ, Affiliated Hosp 1, Dept Endocrinol, Kunming 650032, Yunnan, Peoples R China.
   [Huang, Jingshan] Univ S Alabama, Sch Comp, Mobile, AL 36688 USA.
   [Fukuo, Keisuke] Mukogawa Womens Univ, Sch Human Environm Sci, Dept Food Sci & Nutr, 6-46 Ikebiraki Cho, Nishinomiya, Hyogo 6638558, Japan.
   [Fukuo, Keisuke; Kazumi, Tsutomu] Mukogawa Womens Univ, Res Inst Nutr Sci, 6-46 Ikebiraki Cho, Nishinomiya, Hyogo 6638558, Japan.
   [Yoshino, Gen] Toho Univ, Omori Med Ctr, Dept Diabet & Endocrinol, Omori Ku, Omorinishi 6-11-1, Tokyo 1438541, Japan.
C3 Mukogawa Women's University; Kunming Medical University; University of
   South Alabama; Mukogawa Women's University; Mukogawa Women's University;
   Toho University
RP Wu, B (corresponding author), Mukogawa Womens Univ, Open Res Ctr Studying Lifestyle Related Dis, 6-46 Ikebiraki Cho, Nishinomiya, Hyogo 6638558, Japan.; Wu, B (corresponding author), Kunming Med Univ, Affiliated Hosp 1, Dept Endocrinol, Kunming 650032, Yunnan, Peoples R China.
EM wu.bin.kmu@qq.com
RI Wu, Bin/R-7389-2019
OI Kazumi, Tsutomu/0000-0002-8855-9268; Wu, Bin/0000-0002-0399-0762; Huang,
   Jingshan/0000-0003-2408-2883
FU Ministry of Education, Culture, Sports, Science, and Technology (MEXT)
   of Japan; National Natural Science Foundation of China (NSFC)
   [81660141]; Science and Technology Department of the Applied Basic
   Research Foundation of Yunnan Province [2015FB023]; National Cancer
   Institute (NCI) of the National Institutes of Health (NIH) [U01CA180982]
FX The authors are indebted to all the participants for their dedicated and
   conscientious collaboration. They also thank Mami Toyasaki and Rumi
   Fukada for their work on sampling and data collection. This study was
   supported by the Open Research Center Project for Private University:
   Matching Fund Subsidy for Private Universities from the Ministry of
   Education, Culture, Sports, Science, and Technology (MEXT) of Japan. In
   addition, the research reported in this paper was partially supported by
   (1) the National Natural Science Foundation of China (NSFC) (Award no.
   81660141), (2) the Science and Technology Department of the Applied
   Basic Research Foundation of Yunnan Province (no. 2015FB023), and (3)
   the National Cancer Institute (NCI) of the National Institutes of Health
   (NIH) (Award no. U01CA180982).
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Borel AL, 2012, OBESITY, V20, P1223, DOI 10.1038/oby.2011.396
   BORKAN GA, 1982, AM J CLIN NUTR, V36, P172, DOI 10.1093/ajcn/36.1.172
   Bots ML, 1997, J CLIN EPIDEMIOL, V50, P801, DOI 10.1016/S0895-4356(97)00059-0
   Buemann B, 2006, J CLIN ENDOCR METAB, V91, P1698, DOI 10.1210/jc.2005-1062
   Dobbelsteyn CJ, 2001, INT J OBESITY, V25, P652, DOI 10.1038/sj.ijo.0801582
   Ferndández JR, 2003, AM J CLIN NUTR, V77, P71, DOI 10.1093/ajcn/77.1.71
   FRIEDEWALD WT, 1972, CLIN CHEM, V18
   Giraud DW, 2001, NUTR RES, V21, P961, DOI 10.1016/S0271-5317(01)00309-8
   Goodpaster BH, 2000, AM J CLIN NUTR, V71, P885
   Hanley AJG, 2007, J CLIN ENDOCR METAB, V92, P2665, DOI 10.1210/jc.2006-2614
   Hirano T, 2003, J LIPID RES, V44, P2193, DOI 10.1194/jlr.D300007-JLR200
   Horber FF, 1997, NUTRITION, V13, P524, DOI 10.1016/S0899-9007(97)00031-2
   Kabir M, 2005, AM J PHYSIOL-ENDOC M, V288, pE454, DOI 10.1152/ajpendo.00203.2004
   Kadota K, 2008, CIRC J, V72, P304, DOI 10.1253/circj.72.304
   Kamel EG, 1999, INT J OBESITY, V23, P686, DOI 10.1038/sj.ijo.0800904
   Kamel EG, 2000, OBES RES, V8, P36, DOI 10.1038/oby.2000.6
   Kantartzis K, 2005, OBES RES, V13, P1683, DOI 10.1038/oby.2005.206
   Karpe F, 2001, J LIPID RES, V42, P17
   KOBAYASHI J, 1993, CLIN CHIM ACTA, V216, P113, DOI 10.1016/0009-8981(93)90144-S
   Matsuda M, 1999, DIABETES CARE, V22, P1462, DOI 10.2337/diacare.22.9.1462
   Matsuzawa Y, 2005, J ATHEROSCLER THROMB, V12, P301, DOI 10.5551/jat.12.301
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   MEADE TW, 1993, LANCET, V342, P1076, DOI 10.1016/0140-6736(93)92062-X
   Meigs JB, 2006, J CLIN ENDOCR METAB, V91, P2906, DOI 10.1210/jc.2006-0594
   Miljkovic-Gacic I, 2008, METABOLISM, V57, P819, DOI 10.1016/j.metabol.2008.01.022
   Misra A, 1997, OBES RES, V5, P93, DOI 10.1002/j.1550-8528.1997.tb00648.x
   Miyazaki Y, 2002, J CLIN ENDOCR METAB, V87, P2784, DOI 10.1210/jc.87.6.2784
   Paradisi G, 1999, DIABETES CARE, V22, P1310, DOI 10.2337/diacare.22.8.1310
   Plourde G, 1997, NUTR REV, V55, P289, DOI 10.1111/j.1753-4887.1997.tb05487.x
   Roberts LJ, 1997, BBA-LIPID LIPID MET, V1345, P121, DOI 10.1016/S0005-2760(96)00162-2
   Snijder MB, 2003, AM J CLIN NUTR, V77, P1192, DOI 10.1093/ajcn/77.5.1192
   Snijder MB, 2004, DIABETES CARE, V27, P372, DOI 10.2337/diacare.27.2.372
   Tankó LB, 2003, CIRCULATION, V107, P1626, DOI 10.1161/01.CIR.0000057974.74060.68
   Tatsukawa H, 2000, P SOC EXP BIOL MED, V223, P156, DOI 10.1046/j.1525-1373.2000.22321.x
   Twicker TB, 2004, CIRCULATION, V109, P1918, DOI 10.1161/01.CIR.0000125278.58527.F3
   Van Pelt RE, 2002, AM J PHYSIOL-ENDOC M, V282, pE1023, DOI 10.1152/ajpendo.00467.2001
   Varbo A, 2015, CIRC RES, V116, P665, DOI 10.1161/CIRCRESAHA.116.304846
   WANG J, 1994, AM J CLIN NUTR, V60, P23, DOI 10.1093/ajcn/60.1.23
   Wiklund P, 2008, J CLIN ENDOCR METAB, V93, P4360, DOI 10.1210/jc.2008-0804
NR 40
TC 18
Z9 20
U1 0
U2 4
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2018
VL 2018
AR 1289485
DI 10.1155/2018/1289485
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FW6FQ
UT WOS:000425414000001
PM 29531527
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Skorodensky, M
   Skodová, Z
   Takác, P
   Mechírová, V
   Pálová, E
   Tajtáková, M
   Gibalová, M
AF Skorodensky, Miroslav
   Skodova, Zuzana
   Takac, Peter
   Mechirova, Viola
   Palova, Eva
   Tajtakova, Maria
   Gibalova, Martina
TI Psychological, medical and bio-behavioral factors in coronary heart
   disease
SO STUDIA PSYCHOLOGICA
LA English
DT Article
DE hostility; depression; coronary heart disease; metabolic syndrome;
   growth hormone insufficiency
ID ORGANIC-DISEASE; DEPRESSION; MORTALITY
AB The aim of this study is to emphasize the importance of an integrative bio-behavioral approach to coronary heart disease. We explored relationships between psychological characteristics and traditional biomedical risk factors of coronary heart disease, by using specific methods not commonly used in Slovakia (VCE interview, RIA serotonin levels assessment). A structured interview was conducted with 89 patients, who were divided into 4 diagnostic groups: 1) cardiac patients after myocardial infarction (MI), 2) patients suffering from metabolic syndrome, 3) patients with depression, and 4) participants with growth hormone insufficiency. The VCE interview (Friedman, Ghandour, 1993) was used to assess the levels of free-floating hostility and time urgency. Beck's questionnaires (BDI, BAI) and Zung's inventory were employed in order to explore depression and anxiety. The B.P.A.I. questionnaire was used as the measure of anger and hostility. Medical and biochemical examinations were also performed (e.g., BMI, blood pressure, Doppler, EKG, cholesterol, serotonin). ANOVA, Pearson's coefficients and factor analysis were used as the statistical methods. Cardiac patients after MI scored significantly higher in free-floating hostility, time urgency and total score of the VCE interview compared to all other groups. It has been shown that results of the VCE structured interview are efficient in distinguishing patients with coronary heart disease from patients without this disorder. Cardiac patients also had higher levels of anxiety and depression, which were significantly associated with the lowest serotonin levels in this group. The group of patients with metabolic syndrome had higher levels of the above-mentioned variables compared to the group with depression and growth hormone insufficiency, which illustrates on the psychological level that metabolic syndrome might be perceived as an antecedent of future coronary heart disease. The trend of higher cardiac risk in patients suffering from depression was also partially confirmed. The results of the present study showed that psychosocial factors, especially free-floating hostility and time urgency, are strongly connected to the somatic risk factors which play an important role in the origin and development of coronary heart disease. More attention should be paid to psychosocial factors when considering the treatment and prevention of coronary heart disease.
C1 [Skorodensky, Miroslav; Gibalova, Martina] Univ Presov, Philosophy Fac, Inst Psychol, Dept Clin Psychol & Hlth Psychol, Presov, Slovakia.
   [Skodova, Zuzana] Safarik Univ, Fac Arts, Dept Educ & Hlth Psychol, Kosice, Slovakia.
   [Takac, Peter; Palova, Eva; Tajtakova, Maria] Fac Hosp L Pasteur, Kosice, Slovakia.
   [Takac, Peter] Med Fac UPJS, Dept Phys Med & Rehabil, Kosice, Slovakia.
   [Mechirova, Viola] Med Fac UPJS, Inst Bachelor & Master Study, Kosice, Slovakia.
   [Palova, Eva] Med Fac UPJS, Psychiat Clin, Kosice, Slovakia.
   [Tajtakova, Maria] Med Fac UPJS, Internal Clin 1, Kosice, Slovakia.
C3 University of Presov; University of Pavol Jozef Safarik Kosice;
   University of Pavol Jozef Safarik Kosice; University of Pavol Jozef
   Safarik Kosice; University of Pavol Jozef Safarik Kosice; University of
   Pavol Jozef Safarik Kosice
RP Skorodensky, M (corresponding author), Univ Presov, Philosophy Fac, Inst Psychol, Dept Clin Psychol & Hlth Psychol, 17 Novembra 1, Presov, Slovakia.
EM skorodensky@atknet.sk
RI Palova, Eva/AAD-5304-2019; Skodova, Zuzana/F-8133-2013
OI Skodova, Zuzana/0000-0002-1885-6443; Takac, Peter/0000-0002-6615-1894
CR [Anonymous], PSYCHOSOMATICKA MED
   Beck A. T., 1990, Manual for the Beck anxiety inventory
   BOYLE SH, 2004, PSYCHOSOM MED, V66, P5
   Carney RM, 2004, PSYCHOSOM MED, V66, P799, DOI 10.1097/01.psy.0000146795.38162.b1
   FRIEDMAN M, 1993, AM HEART J, V126, P607, DOI 10.1016/0002-8703(93)90411-2
   Joynt KE, 2003, BIOL PSYCHIAT, V54, P248, DOI 10.1016/S0006-3223(03)00568-7
   Kandel ER, 2000, SCIENCE, V290, P1113, DOI 10.1126/science.290.5494.1113
   Kandel ER, 1998, AM J PSYCHIAT, V155, P457, DOI 10.1176/ajp.155.4.457
   Kemp DE, 2003, CLEV CLIN J MED, V70, P745, DOI 10.3949/ccjm.70.9.745
   KENNERLY RC, 2003, BRIEF HIST ORIGINS B
   Kop WJ, 1997, J PSYCHOSOM RES, V43, P167, DOI 10.1016/S0022-3999(97)80002-5
   Kop WJ, 2003, BRAIN BEHAV IMMUN, V17, P233, DOI 10.1016/S0889-1591(03)00051-5
   Kopp MS, 2004, BRAIN RES BULL, V62, P351, DOI 10.1016/j.brainresbull.2003.12.001
   Kotseva K, 2001, LANCET, V357, P995, DOI 10.1016/S0140-6736(00)04235-5
   Krantz DS, 2002, ANNU REV PSYCHOL, V53, P341, DOI 10.1146/annurev.psych.53.100901.135208
   Pichot P, 1974, PSYCHOL MEASUREMENTS, V7, P151
   ROSSI EL, 2005, ANNALS, V4, P4
   Sparagon B, 2001, ATHEROSCLEROSIS, V156, P145, DOI 10.1016/S0021-9150(00)00604-3
   STEPTOE A, 2005, CORONARY HEART DIS E
   Williams RB, 2002, PSYCHOSOM MED, V64, P552, DOI 10.1097/01.PSY.0000023410.02546.5D
   Williams Redford B., 1995, P403
   ZUNG WWK, 1965, ARCH GEN PSYCHIAT, V12, P63, DOI 10.1001/archpsyc.1965.01720310065008
NR 22
TC 0
Z9 0
U1 0
U2 4
PU SLOVAK ACAD SCIENCES, CTR SOCIAL & PSYCHOLOGICAL SCIENCES, IEP
PI BRATISLAVA
PA DUBRAVSKA CESTA 9, 813 64 BRATISLAVA, SLOVAKIA
SN 0039-3320
EI 2585-8815
J9 STUD PSYCHOL
JI Studia Psychol.
PY 2007
VL 49
IS 4
BP 321
EP 331
PG 11
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA 257SQ
UT WOS:000252819200004
DA 2025-06-11
ER

PT J
AU Yates, KF
   Sweat, V
   Yau, PL
   Turchiano, MM
   Convit, A
AF Yates, Kathy F.
   Sweat, Victoria
   Yau, Po Lai
   Turchiano, Michael M.
   Convit, Antonio
TI Impact of Metabolic Syndrome on Cognition and Brain A Selected Review of
   the Literature
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Review
DE metabolic syndrome; cognitive performance; adults; adolescents; brain
   imaging
ID INTIMA-MEDIA THICKNESS; INSULIN-RESISTANCE SYNDROME; TYPE-2
   DIABETES-MELLITUS; SCHOOL-AGE-CHILDREN; OBESE ADOLESCENTS;
   BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; EXECUTIVE DYSFUNCTION; ARTERIAL
   STIFFNESS; UNITED-STATES
AB Metabolic syndrome (MetS), a clustering of risk factors for type 2 diabetes mellitus and cardiovascular disease, has been associated with cognitive dysfunction and brain abnormalities. This review describes the literature on the impact of MetS on brain and cognition and suggests directions for future research. A literature search for reports of MetS and cognition and brain imaging was conducted for both nonelderly adults and adolescents. No studies were found describing MetS and brain or cognition among adolescents; therefore, we also included studies investigating individual components of MetS in this age group. Most studies found associations between MetS and cognitive dysfunction. Multiple cognitive domains were affected by MetS in adults. In adolescents, the majority of findings were in executive functioning. Brain imaging literature in adults implicated MetS in ischemic stroke, white matter alterations, and altered brain metabolism. For adolescents, individual MetS factors were linked to volume losses in the hippocampus and frontal lobes. MetS negatively impacts cognitive performance and brain structure. Potential explanatory models include impaired vascular reactivity, neuroinflammation, oxidative stress, and abnormal brain lipid metabolism. We posit that insulin resistance-associated impairment in cerebrovascular reactivity is an important mechanism underlying brain deficits seen in MetS. (Arterioscler Thromb Vasc Biol. 2012;32:2060-2067.)
C1 [Convit, Antonio] NYU, Sch Med, Brain Obes & Diabet Lab BODyLab, Dept Psychiat, New York, NY 10016 USA.
   [Convit, Antonio] NYU, Sch Med, Dept Med, New York, NY 10016 USA.
   [Yates, Kathy F.; Convit, Antonio] Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA.
C3 New York University; New York University; Nathan Kline Institute for
   Psychiatric Research
RP Convit, A (corresponding author), NYU, Sch Med, Brain Obes & Diabet Lab BODyLab, Dept Psychiat, 145 E 32nd St,8th Floor, New York, NY 10016 USA.
EM Antonio.Convit@NYUMC.org
OI Yates, Kathy/0000-0002-1844-8431; Convit, Antonio/0000-0003-2201-2689;
   Yau, Po Lai/0000-0002-2901-2705
FU National Institutes of Health [DK064087, DK083537]
FX The study was supported by National Institutes of Health grants DK064087
   and DK083537.
CR Ajilore O, 2007, NEUROPSYCHOPHARMACOL, V32, P1224, DOI 10.1038/sj.npp.1301248
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Bokura H, 2008, STROKE, V39, P1607, DOI 10.1161/STROKEAHA.107.508630
   Bokura H, 2010, DEMENT GERIATR COGN, V30, P479, DOI 10.1159/000322057
   Bourdel-Marchasson I, 2010, DIABETES METAB, V36, P173, DOI 10.1016/j.diabet.2010.03.001
   BRETELER MMB, 1994, NEUROLOGY, V44, P1246, DOI 10.1212/WNL.44.7.1246
   Breteler MMB, 2000, ANN NY ACAD SCI, V903, P457, DOI 10.1111/j.1749-6632.2000.tb06399.x
   Bruehl Hannah, 2011, Neurosci Med, V2, P34
   Case CC, 2002, DIABETES OBES METAB, V4, P407, DOI 10.1046/j.1463-1326.2002.00236.x
   Cavalier M, 2010, DIABETES CARE, V33, P2489, DOI 10.2337/dc10-0851
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Clow A, 2004, STRESS, V7, P29, DOI 10.1080/10253890410001667205
   Convit A, 2005, NEUROBIOL AGING, V26, pS31, DOI 10.1016/j.neurobiolaging.2005.09.018
   Cook S, 2008, J PEDIATR, V152, P165, DOI 10.1016/j.jpeds.2007.06.004
   Crichton GE., 2011, J ALZHEIMERS DIS
   Cserjési R, 2007, APPETITE, V49, P675, DOI 10.1016/j.appet.2007.04.001
   Drake CT, 2007, BRAIN LANG, V102, P141, DOI 10.1016/j.bandl.2006.08.002
   Ervin R Bethene, 2009, Natl Health Stat Report, P1
   Frisardi V, 2010, J ALZHEIMERS DIS, V21, P57, DOI 10.3233/JAD-2010-100015
   Gatto NM, 2008, AGING NEUROPSYCHOL C, V15, P627, DOI 10.1080/13825580802036936
   Giannopoulos S, 2010, EUR J NEUROL, V17, P1457, DOI 10.1111/j.1468-1331.2010.03087.x
   Gold SM, 2005, J CLIN ENDOCR METAB, V90, P3262, DOI 10.1210/jc.2004-2181
   Gunstad J, 2008, APPETITE, V50, P246, DOI 10.1016/j.appet.2007.07.008
   HAFFNER SM, 1992, DIABETES, V41, P715, DOI 10.2337/diabetes.41.6.715
   Haley AP, 2010, METAB BRAIN DIS, V25, P397, DOI 10.1007/s11011-010-9221-y
   Hao ZL, 2011, ACTA NEUROPSYCHIATR, V23, P69, DOI 10.1111/j.1601-5215.2011.00527.x
   Haring R, 2009, DIABETES, V58, P2027, DOI 10.2337/db09-0031
   Hassenstab JJ, 2010, DEMENT GERIATR COGN, V29, P356, DOI 10.1159/000296071
   Hoth KF, 2011, AM J NEURORADIOL, V32, P541, DOI 10.3174/ajnr.A2315
   Huang K, 2010, ARCH PEDIAT ADOL MED, V164, P846, DOI 10.1001/archpediatrics.2010.160
   Iannuzzi A, 2006, AM J CARDIOL, V97, P528, DOI 10.1016/j.amjcard.2005.08.072
   Jeppesen J, 2007, J AM COLL CARDIOL, V49, P2112, DOI 10.1016/j.jacc.2007.01.088
   Kastorini CM, 2011, J AM COLL CARDIOL, V57, P1299, DOI 10.1016/j.jacc.2010.09.073
   Koivistoinen T, 2011, ANN MED, V43, P312, DOI 10.3109/07853890.2010.549145
   Komulainen P, 2007, NEUROEPIDEMIOLOGY, V28, P207, DOI 10.1159/000108112
   Komulainen P, 2007, DEMENT GERIATR COGN, V23, P29, DOI 10.1159/000096636
   Kotb NA, 2012, DIABETES VASC DIS RE, V9, P35, DOI 10.1177/1479164111421804
   Kurl S, 2006, STROKE, V37, P806, DOI 10.1161/01.STR.0000204354.06965.44
   Kwon HM, 2009, J NEUROL, V256, P1825, DOI 10.1007/s00415-009-5201-8
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lande MB, 2003, J PEDIATR-US, V143, P720, DOI 10.1067/S0022-3476(03)00412-8
   Li YF, 2008, OBESITY, V16, P1809, DOI 10.1038/oby.2008.296
   Logroscino G, 2004, BMJ-BRIT MED J, V328, P548, DOI 10.1136/bmj.37977.495729.EE
   Lokken KL, 2009, SURG OBES RELAT DIS, V5, P547, DOI 10.1016/j.soard.2009.05.008
   Maayan L, 2011, OBESITY, V19, P1382, DOI 10.1038/oby.2011.15
   Manschot SM, 2007, DIABETOLOGIA, V50, P2388, DOI 10.1007/s00125-007-0792-z
   Muller M, 2009, J NEUROL SCI, V283, P307, DOI 10.1016/j.jns.2009.02.257
   Muller M, 2011, ANN NEUROL, V70, P237, DOI 10.1002/ana.22392
   Muller M, 2010, NEUROEPIDEMIOLOGY, V34, P83, DOI 10.1159/000264825
   Pall D, 2012, KIDNEY BLOOD PRESS R, V35, P129, DOI 10.1159/000331057
   Pandit D, 2011, J PEDIATR ENDOCR MET, V24, P97, DOI 10.1515/JPEM.2011.086
   Parisi P, 2010, J PEDIATR ENDOCR MET, V23, P1133, DOI 10.1515/jpem.2010.178
   Park JH, 2008, CLIN NEUROL NEUROSUR, V110, P215, DOI 10.1016/j.clineuro.2007.10.016
   Park K, 2008, J NEUROL NEUROSUR PS, V79, P719, DOI 10.1136/jnnp.2007.134809
   Pauli-Pott U, 2010, CHILD NEUROPSYCHOL, V16, P592, DOI 10.1080/09297049.2010.485980
   Potenza MV, 2009, NUTR CLIN PRACT, V24, P560, DOI 10.1177/0884533609342436
   Raji CA, 2010, HUM BRAIN MAPP, V31, P353, DOI 10.1002/hbm.20870
   REAVEN GM, 1993, ANNU REV MED, V44, P121, DOI 10.1146/annurev.med.44.1.121
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Romero JR, 2009, STROKE, V40, P1590, DOI 10.1161/STROKEAHA.108.535245
   Ryan CM, 2006, DIABETES CARE, V29, P345, DOI 10.2337/diacare.29.02.06.dc05-1626
   Schuur M, 2010, EUR J EPIDEMIOL, V25, P561, DOI 10.1007/s10654-010-9476-y
   Segura B, 2009, REV NEUROLOGIA, V49, P417, DOI 10.33588/rn.4908.2008425
   Segura B, 2009, NEUROLOGY, V73, P438, DOI 10.1212/WNL.0b013e3181b163cd
   Segura B, 2009, NEUROSCI LETT, V462, P49, DOI 10.1016/j.neulet.2009.06.071
   Settakis G, 2006, KIDNEY BLOOD PRESS R, V29, P306, DOI 10.1159/000097018
   Sipilä K, 2009, ATHEROSCLEROSIS, V204, P276, DOI 10.1016/j.atherosclerosis.2008.08.029
   Smith E, 2011, OBES REV, V12, P740, DOI 10.1111/j.1467-789X.2011.00920.x
   Sowell ER, 2001, J INT NEUROPSYCH SOC, V7, P312, DOI 10.1017/S135561770173305X
   Stabouli S, 2012, HELL J CARDIOL, V53, P41
   Tooke JE, 1998, DIABETES CARE, V21, P2047, DOI 10.2337/diacare.21.12.2047
   Tooke JE, 2000, J INTERN MED, V247, P425, DOI 10.1046/j.1365-2796.2000.00671.x
   Tournoy J, 2010, DIABETES-METAB RES, V26, P668, DOI 10.1002/dmrr.1144
   Urbina EM, 2009, CIRCULATION, V119, P2913, DOI 10.1161/CIRCULATIONAHA.108.830380
   Ursache A, 2012, PSYCHONEUROENDOCRINO, V37, P1270, DOI 10.1016/j.psyneuen.2011.12.020
   Verdejo-García A, 2010, OBESITY, V18, P1572, DOI 10.1038/oby.2009.475
   Ward MA, 2010, FRONT AGING NEUROSCI, V2, DOI 10.3389/fnagi.2010.00029
   Wong LJ, 2011, STROKE, V42, P1834, DOI 10.1161/STROKEAHA.110.607606
   Yaffe K, 2004, JAMA-J AM MED ASSOC, V292, P2237, DOI 10.1001/jama.292.18.2237
   Yau PL, 2010, DIABETOLOGIA, V53, P2298, DOI 10.1007/s00125-010-1857-y
   ZAVARONI I, 1989, NEW ENGL J MED, V320, P702, DOI 10.1056/NEJM198903163201105
   Zebekakis PE, 2005, J HYPERTENS, V23, P1839, DOI 10.1097/01.hjh.0000179511.93889.e9
   Zhu WH, 2005, EUR J PEDIATR, V164, P337, DOI 10.1007/s00431-005-1642-y
NR 84
TC 333
Z9 363
U1 1
U2 62
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD SEP
PY 2012
VL 32
IS 9
BP 2060
EP 2067
DI 10.1161/ATVBAHA.112.252759
PG 8
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 992JZ
UT WOS:000307773100007
PM 22895667
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Mangurian, C
   Niu, GC
   Schillinger, D
   Newcomer, JW
   Dilley, J
   Handley, MA
AF Mangurian, Christina
   Niu, Grace C.
   Schillinger, Dean
   Newcomer, John W.
   Dilley, James
   Handley, Margaret A.
TI Utilization of the Behavior Change Wheel framework to develop a model to
   improve cardiometabolic screening for people with severe mental illness
SO IMPLEMENTATION SCIENCE
LA English
DT Article
DE Cardiometabolic screening; Severe mental illness; Behavior change wheel
ID CLINICAL DECISION-SUPPORT; MEDICAL-CARE MANAGEMENT; COLLABORATIVE CARE;
   HEALTH-CARE; DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME; IMPLEMENTATION;
   SCHIZOPHRENIA; INTERVENTIONS; IMPACT
AB Background: Individuals with severe mental illness (e.g., schizophrenia, bipolar disorder) die 10-25 years earlier than the general population, primarily from premature cardiovascular disease (CVD). Contributing factors are complex, but include systemic-related factors of poorly integrated primary care and mental health services. Although evidence-based models exist for integrating mental health care into primary care settings, the evidence base for integrating medical care into specialty mental health settings is limited. Such models are referred to as "reverse" integration. In this paper, we describe the application of an implementation science framework in designing a model to improve CVD outcomes for individuals with severe mental illness (SMI) who receive services in a community mental health setting.
   Methods: Using principles from the theory of planned behavior, focus groups were conducted to understand stakeholder perspectives of barriers to CVD risk factor screening and treatment identify potential target behaviors. We then applied results to the overarching Behavior Change Wheel framework, a systematic and theory-driven approach that incorporates the COM-B model (capability, opportunity, motivation, and behavior), to build an intervention to improve CVD risk factor screening and treatment for people with SMI.
   Results: Following a stepped approach from the Behavior Change Wheel framework, a model to deliver primary preventive care for people that use community mental health settings as their de facto health home was developed. The CRANIUM (cardiometabolic risk assessment and treatment through a novel integration model for underserved populations with mental illness) model focuses on engaging community psychiatrists to expand their scope of practice to become responsible for CVD risk, with significant clinical decision support.
   Conclusion: The CRANIUM model was designed by integrating behavioral change theory and implementation theory. CRANIUM is feasible to implement, is highly acceptable to, and targets provider behavior change, and is replicable and efficient for helping to integrate primary preventive care services in community mental health settings. CRANIUM can be scaled up to increase CVD preventive care delivery and ultimately improve health outcomes among people with SMI served within a public mental health care system.
C1 [Mangurian, Christina; Niu, Grace C.; Dilley, James] UCSF Zuckerberg San Francisco Gen ZSFG, Weill Inst Neurosci, Dept Psychiat, 1001 Potrero Ave, San Francisco, CA 94110 USA.
   [Mangurian, Christina; Schillinger, Dean; Handley, Margaret A.] UCSF Ctr Vulnerable Populat ZSFG, San Francisco, CA 94110 USA.
   [Schillinger, Dean; Handley, Margaret A.] UCSF Dept Med, Div Gen Internal Med ZSFG, 1001 Potrero Ave,1320A, San Francisco, CA 94110 USA.
   [Newcomer, John W.] Florida Atlantic Univ, Charles E Schmidt Coll Med, Dept Clin Biomed Sci, 777 Glades Rd,BC-71 Rm 241, Boca Raton, FL 33431 USA.
   [Handley, Margaret A.] UCSF Dept Epidemiol & Biostat, 550 16th St, San Francisco, CA 64158 USA.
C3 State University System of Florida; Florida Atlantic University
RP Mangurian, C (corresponding author), UCSF Zuckerberg San Francisco Gen ZSFG, Weill Inst Neurosci, Dept Psychiat, 1001 Potrero Ave, San Francisco, CA 94110 USA.; Mangurian, C (corresponding author), UCSF Ctr Vulnerable Populat ZSFG, San Francisco, CA 94110 USA.
EM Christina.Mangurian@ucsf.edu
OI Newcomer, John/0000-0003-2153-9382
FU National Institutes of Mental Health [1K23MH093689]; UCSF Hellman
   Fellows Award for Early-Career Faculty; National Center for Research
   Resources; National Center for Advancing Translational Sciences; Office
   of the Director, National Institutes of Health, through UCSF-CTSI
   [KL2RR024130]; NIH [2T32MH018261]; University of Washington AIMS Center;
   NIH from the National Institute of Diabetes and Digestive and Kidney
   Diseases for The Health Delivery Systems-Center for Diabetes
   Translational Research (CDTR) [P30DK092924]; NIH/National Institute of
   Minority Health and Health Disparities (NIMHD) Comprehensive Center of
   Excellence for Health and Risk in Minority Youth and Young Adults
   [P60MD006902]; National Center for Advancing Translational Sciences,
   National Institutes of Health, through UCSF-CTSI [UL1TR001872]; National
   Center for Advancing Translational Sciences [UL1TR001872] Funding
   Source: NIH RePORTER; National Institute of Mental Health [T32MH018261]
   Funding Source: NIH RePORTER
FX CM was supported by the National Institutes of Mental Health
   (1K23MH093689), the UCSF Hellman Fellows Award for Early-Career Faculty,
   and the National Center for Research Resources, the National Center for
   Advancing Translational Sciences, and the Office of the Director,
   National Institutes of Health, through UCSF-CTSI Grant Number
   KL2RR024130. GN was supported by the NIH Ruth L. Kirschstein National
   Research Service Award (2T32MH018261) and consulting fees from
   University of Washington AIMS Center. DS and MH were supported by the
   NIH Center Grant from the National Institute of Diabetes and Digestive
   and Kidney Diseases for The Health Delivery Systems-Center for Diabetes
   Translational Research (CDTR) (P30DK092924) and the NIH/National
   Institute of Minority Health and Health Disparities (NIMHD)
   Comprehensive Center of Excellence for Health and Risk in Minority Youth
   and Young Adults (P60MD006902). MH was also supported by the National
   Center for Advancing Translational Sciences, National Institutes of
   Health, through UCSF-CTSI Grant Number UL1TR001872. The contents are
   solely the responsibility of the authors and do not necessarily
   represent the official views of the NIH. The NIH did not play a role in
   the design of the study or collection, analysis, or interpretation of
   data, or in writing the manuscript.
CR AJZEN I, 1991, ORGAN BEHAV HUM DEC, V50, P179, DOI 10.1016/0749-5978(91)90020-T
   Alakeson V, 2010, HEALTH AFFAIR, V29, P867, DOI 10.1377/hlthaff.2010.0080
   Alexander L., 2012, Behavioral health homes for people with mental health and substance use conditions: The core clinical features
   Amer Diabet Assoc, 2004, DIABETES CARE, V27, P596, DOI 10.2337/diacare.27.2.596
   Amiel JM, 2011, CURR OPIN PSYCHIATR, V24, P562, DOI 10.1097/YCO.0b013e32834baa97
   [Anonymous], 2012, Psychiatr Serv, V63, P1055, DOI 10.1176/appi.ps.1012
   [Anonymous], IMPLEMENT SCI
   [Anonymous], IMPLEMENT SCI
   [Anonymous], IMPLEMENT SCI
   [Anonymous], IMPLEMENT SCI
   [Anonymous], HLTH HOM MED HOM
   [Anonymous], IMPLEMENT SCI
   [Anonymous], IMPR QUAL HLTH CAR M
   [Anonymous], IMPLEMENT SCI
   [Anonymous], TRIALS
   [Anonymous], BMC HEALTH SERV RES
   [Anonymous], COMMUNITY M IN PRESS
   [Anonymous], DEPR PRIM CAR TREATM
   Atkins L, 2017, IMPLEMENT SCI, V12, DOI 10.1186/s13012-017-0605-9
   Barnes TRE, 2008, ACTA PSYCHIAT SCAND, V118, P26, DOI 10.1111/j.1600-0447.2008.01203.x
   Bauer AM, 2013, EVID-BASED MENT HEAL, V16, P40, DOI 10.1136/eb-2012-101139
   Bauer MS, 2006, PSYCHIAT SERV, V57, P937, DOI 10.1176/appi.ps.57.7.937
   Berren MR, 1999, PSYCHIAT SERV, V50, P559, DOI 10.1176/ps.50.4.559
   Bodenheimer T, 2002, JAMA-J AM MED ASSOC, V288, P1775, DOI 10.1001/jama.288.14.1775
   Boulware LE, 2001, AM J PREV MED, V21, P221, DOI 10.1016/S0749-3797(01)00356-7
   Bower P, 2005, BRIT J PSYCHIAT, V186, P11, DOI 10.1192/bjp.186.1.11
   Bradford DW, 2013, J CLIN PSYCHIAT, V74, pE754, DOI 10.4088/JCP.12r07666
   Burton A, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0136603
   Cabassa LJ, 2017, J PSYCHIATR RES, V84, P80, DOI 10.1016/j.jpsychires.2016.09.021
   Cabassa LJ, 2011, IMPLEMENT SCI, V6, DOI 10.1186/1748-5908-6-80
   Cane J, 2012, IMPLEMENT SCI, V7, DOI 10.1186/1748-5908-7-37
   Chwastiak LA, 2008, J GEN INTERN MED, V23, P1835, DOI 10.1007/s11606-008-0786-7
   Collins C., 2010, EVOLVING MODELS BEHA
   Colquhoun HL, 2017, IMPLEMENT SCI, V12, DOI 10.1186/s13012-017-0560-5
   Colton Craig W, 2006, Prev Chronic Dis, V3, pA42
   Copeland LA, 2009, BMC HEALTH SERV RES, V9, DOI 10.1186/1472-6963-9-127
   Damschroder LJ, 2009, IMPLEMENT SCI, V4, DOI 10.1186/1748-5908-4-50
   Daumit GL, 2013, NEW ENGL J MED, V368, P1594, DOI 10.1056/NEJMoa1214530
   DelMonte MT, 2012, J CLIN PHARM THER, V37, P668, DOI 10.1111/j.1365-2710.2012.01369.x
   Druss BG, 2008, PSYCHIAT SERV, V59, P917, DOI 10.1176/ps.2008.59.8.917
   Druss BG, 2017, AM J PSYCHIAT, V174, P246, DOI 10.1176/appi.ajp.2016.16050507
   Druss BG, 2011, AM J PSYCHIAT, V168, P1171, DOI 10.1176/appi.ajp.2011.11010071
   Druss BG, 2010, AM J PSYCHIAT, V167, P151, DOI 10.1176/appi.ajp.2009.09050691
   Druss BG, 2006, GEN HOSP PSYCHIAT, V28, P145, DOI 10.1016/j.genhosppsych.2005.10.006
   Gilbody S, 2006, ARCH INTERN MED, V166, P2314, DOI 10.1001/archinte.166.21.2314
   Gilmer TP, 2012, HEALTH SERV RES, V47, P2137, DOI 10.1111/j.1475-6773.2012.01427.x
   Giorda C, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033839
   Glasgow RE, 1999, AM J PUBLIC HEALTH, V89, P1322, DOI 10.2105/AJPH.89.9.1322
   Godin G, 1996, AM J HEALTH PROMOT, V11, P87, DOI 10.4278/0890-1171-11.2.87
   Hoffmann TC, 2014, BMJ-BRIT MED J, V348, DOI [10.1136/bmj.g1687, 10.1055/s-0041-111066]
   James PA, 2014, JAMA-J AM MED ASSOC, V311, P1809, DOI [10.1001/jama.2013.284427, 10.1001/jama.2014.4346]
   KATON W, 1990, GEN HOSP PSYCHIAT, V12, P355, DOI 10.1016/0163-8343(90)90002-T
   Katon WJ, 2003, BIOL PSYCHIAT, V54, P216, DOI 10.1016/S0006-3223(03)00273-7
   Kelly DL, 2011, SCHIZOPHRENIA BULL, V37, P832, DOI 10.1093/schbul/sbp152
   Kessler RC, 2001, HEALTH SERV RES, V36, P987
   Keyes CLM, 2007, AM PSYCHOL, V62, P95, DOI 10.1037/0003-066X.62.2.95
   Khaykin E, 2010, PSYCHIAT SERV, V61, P830, DOI 10.1176/ps.2010.61.8.830
   Krein SL, 2006, PSYCHIAT SERV, V57, P1016, DOI 10.1176/appi.ps.57.7.1016
   Kreyenbuhl J, 2017, COMMUNITY MENT HLT J, V53, P163, DOI 10.1007/s10597-016-0007-5
   Kreyenbuhl J, 2010, SCHIZOPHRENIA BULL, V36, P94, DOI 10.1093/schbul/sbp130
   Kreyenbuhl J, 2010, SCHIZOPHRENIA BULL, V36, P428, DOI 10.1093/schbul/sbn106
   Liang L, 2017, IMPLEMENT SCI, V12, DOI 10.1186/s13012-017-0557-0
   Mangurian C, 2015, JAMA INTERN MED, V175, P1977, DOI 10.1001/jamainternmed.2015.6098
   McAlpine DD, 2000, HEALTH SERV RES, V35, P277
   McEvoy JP, 2005, SCHIZOPHR RES, V80, P19, DOI 10.1016/j.schres.2005.07.014
   Michie S, 2005, QUAL SAF HEALTH CARE, V14, P26, DOI 10.1136/qshc.2004.011155
   Miller CJ, 2013, MED CARE, V51, P922, DOI 10.1097/MLR.0b013e3182a3e4c4
   Mitchell AJ, 2012, PSYCHOL MED, V42, P125, DOI 10.1017/S003329171100105X
   Morrato EH, 2011, PHARMACOEPIDEM DR S, V20, P66, DOI 10.1002/pds.2062
   Murray CJL, 2012, LANCET, V380, P2197, DOI 10.1016/S0140-6736(12)61729-2
   Newcomer JW, 2007, JAMA-J AM MED ASSOC, V298, P1794, DOI 10.1001/jama.298.15.1794
   Newcomer JW, 2005, CNS DRUGS, V19, P1
   O'Connor PJ, 2011, ANN FAM MED, V9, P12, DOI 10.1370/afm.1196
   Olfson M, 2015, JAMA PSYCHIAT, V72, P1172, DOI 10.1001/jamapsychiatry.2015.1737
   Osborn D, 2016, TRIALS, V17, DOI 10.1186/s13063-016-1176-9
   Petersen M, 2003, DIABETES CARE, V26, P917
   Piette JD, 2007, PSYCHIAT SERV, V58, P207, DOI 10.1176/appi.ps.58.2.207
   Pincus HA, 2001, J CLIN PSYCHIAT, V62, P5
   Porcheret M, 2014, IMPLEMENT SCI, V9, DOI 10.1186/1748-5908-9-42
   Ramanuj Parashar Pravin, 2013, Ment Health Fam Med, V10, P29
   Reilly S, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009531.pub2
   Richardson WC., 2001, Crossing the quality chasm: a new health system for the 21st century
   Rosenthal TC, 2008, J AM BOARD FAM MED, V21, P427, DOI 10.3122/jabfm.2008.05.070287
   Scharf D M., 2014, Evaluation of the SAMHSA Primary and Behavioral Health Care Integration (PBHCI) grant program: Final report (Task 13)
   Scharf DM, 2013, PSYCHIAT SERV, V64, P660, DOI 10.1176/appi.ps.201200269
   Schneiderhan ME, 2009, PHARMACOTHERAPY, V29, P975, DOI 10.1592/phco.29.8.975
   Smith TE, 2009, PSYCHIAT SERV, V60, P528, DOI 10.1176/appi.ps.60.4.528
   Sniehotta FF, 2014, HEALTH PSYCHOL REV, V8, P1, DOI 10.1080/17437199.2013.869710
   Stone NJ, 2014, CIRCULATION, V129, pS1, DOI 10.1161/01.cir.0000437738.63853.7a
   Stone NJ, 2014, J AM COLL CARDIOL, V63, P2889, DOI 10.1016/j.jacc.2013.11.002
   Thompson A, 2011, AUST NZ J PSYCHIAT, V45, P740, DOI 10.3109/00048674.2011.595370
   Unützer J, 2002, JAMA-J AM MED ASSOC, V288, P2836, DOI 10.1001/jama.288.22.2836
   Velligan DI, 2013, COMMUNITY MENT HLT J, V49, P141, DOI 10.1007/s10597-011-9472-z
   ZUNG WWK, 1993, J FAM PRACTICE, V37, P337
NR 94
TC 48
Z9 52
U1 3
U2 40
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1748-5908
J9 IMPLEMENT SCI
JI Implement. Sci.
PD NOV 14
PY 2017
VL 12
AR 134
DI 10.1186/s13012-017-0663-z
PG 16
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA FM7KZ
UT WOS:000415256900005
PM 29137666
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fiedorowicz, JG
   He, JP
   Merikangas, KR
AF Fiedorowicz, Jess G.
   He, Jianping
   Merikangas, Kathleen R.
TI The association between mood and anxiety disorders with vascular
   diseases and risk factors in a nationally representative sample
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Anxiety disorders; Diabetes mellitus; Hypertension; Obesity; Mood
   disorders; Vascular diseases
ID MAJOR DEPRESSIVE DISORDER; CORONARY-HEART-DISEASE; GENERAL MEDICAL
   CONDITIONS; REPLICATION NCS-R; MENTAL-HEALTH; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; BIPOLAR-DISORDER; EXCESS MORTALITY;
   PSYCHIATRIC-DISORDERS
AB Objective: To investigate the association between mood and anxiety disorders and vascular diseases after controlling for vascular disease risk factors. Methods: Using a nationally representative sample of adults (N=5692) from the National Comorbidity Survey-Replication (NCS-R), participants with mood disorders were hierarchically classified as having any lifetime history of mania, hypomania, or major depression. Anxiety disorders were also assessed. The reference group consisted of those without mental disorders. Vascular disease was determined by self-reported history of heart disease, heart attack, or stroke on the NCS-R survey. Vascular risk factors included diabetes, high blood pressure, and obesity. Results: In multivariate logistic regression models that controlled for obesity, high blood pressure, smoking and diabetes, vascular disease was associated with bipolar disorder in women [odds ratio (OR) 2.80, 95% confidence interval (CI) 1.63-4.80], and major depressive disorder in men (OR 1.85, 95% CI 1.17-2.92). Controlling for anxiety disorders reduced the associations in both men and women, and in fact, anxiety disorders were more strongly associated with vascular diseases in men, whereas bipolar disorder continued to be an important correlate of vascular disease in women. Conclusion: These findings demonstrate the importance of evaluation of sex differences, mood disorder subtype and co-occurring anxiety disorders in assessing the association between mood disorders and vascular diseases. Future research should investigate potential biologic mechanisms for these associations in order to define potential targets for intervention. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Fiedorowicz, Jess G.] Univ Iowa, Dept Psychiat, Roy J & Lucille A Carver Coll Med, Hosp & Clin, Iowa City, IA 52242 USA.
   [Fiedorowicz, Jess G.] Univ Iowa, Dept Epidemiol, Coll Publ Hlth, Iowa City, IA USA.
   [He, Jianping; Merikangas, Kathleen R.] NIMH, Genet Epidemiol Res Branch, Intramural Res Program, Bethesda, MD 20892 USA.
C3 University of Iowa; University of Iowa; National Institutes of Health
   (NIH) - USA; NIH National Institute of Mental Health (NIMH)
RP Fiedorowicz, JG (corresponding author), 200 Hawkins Dr,W278GH, Iowa City, IA 52242 USA.
EM jess-fiedorowicz@uiowa.edu
RI Fiedorowicz, Jess/I-2512-2019; He, JianPing/H-9536-2018
OI Merikangas, Kathkeen/0000-0002-4667-2414; Fiedorowicz,
   Jess/0000-0003-2057-4071
FU Department of Psychiatry at the University of Iowa; National Institute
   of Mental Health; National Institutes of Health [1K23MH083695-01A210];
   NARSAD; Nellie Ball Trust Research Fund; Institute for Clinical and
   Translational Science at the University of Iowa [3 UL1 RR024979-03S4];
   CHDI foundation
FX This work was supported by the Department of Psychiatry at the
   University of Iowa and the Intramural Research Program of the National
   Institute of Mental Health. Dr. Fiedorowicz is supported by the National
   Institutes of Health (1K23MH083695-01A210), NARSAD, the Nellie Ball
   Trust Research Fund, Institute for Clinical and Translational Science at
   the University of Iowa (3 UL1 RR024979-03S4), and CHDI foundation. Dr.
   Fiedorowicz currently serves as a site physician for colleagues' studies
   with Neurosearch, Vitalin/Enzymatic Therapy, and the National Center for
   Complementary and Alternative Medicine/the US Food and Drug
   Administration Orphan Products division.
CR ALLGULANDER C, 1991, ARCH GEN PSYCHIAT, V48, P599
   Angst F, 2002, J AFFECT DISORDERS, V68, P167, DOI 10.1016/S0165-0327(01)00377-9
   Barger SD, 2005, J AFFECT DISORDERS, V88, P87, DOI 10.1016/j.jad.2005.05.012
   Birkenaes AB, 2007, J CLIN PSYCHIAT, V68, P917, DOI 10.4088/JCP.v68n0614
   Blumenthal JA, 2003, LANCET, V362, P604, DOI 10.1016/S0140-6736(03)14190-6
   Cardenas J, 2008, J AFFECT DISORDERS, V106, P91, DOI 10.1016/j.jad.2007.05.030
   Carpenter KM, 2000, AM J PUBLIC HEALTH, V90, P251, DOI 10.2105/AJPH.90.2.251
   Cassidy F, 1999, AM J PSYCHIAT, V156, P1417
   CORYELL W, 1986, AM J PSYCHIAT, V143, P508
   Davis J, 2008, AM J MANAG CARE, V14, P125
   Eaton WW, 1996, DIABETES CARE, V19, P1097, DOI 10.2337/diacare.19.10.1097
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   Fiedorowicz JG, 2008, ANN CLIN PSYCHIATRY, V20, P131, DOI 10.1080/10401230802177722
   Fiedorowicz JG, 2009, PSYCHOSOM MED, V71, P598, DOI 10.1097/PSY.0b013e3181acee26
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   Ford ES, 2005, DIABETES CARE, V28, P2745, DOI 10.2337/diacare.28.11.2745
   Frasure-Smith N, 2008, ARCH GEN PSYCHIAT, V65, P62, DOI 10.1001/archgenpsychiatry.2007.4
   Golden SH, 2008, JAMA-J AM MED ASSOC, V299, P2751, DOI 10.1001/jama.299.23.2751
   Herbst S, 2007, PSYCHOSOM MED, V69, P729, DOI 10.1097/PSY.0b013e3181574977
   Huffman JC, 2008, PSYCHOSOMATICS, V49, P309, DOI 10.1176/appi.psy.49.4.309
   Jeffery RW, 2008, OBESITY, V16, P473, DOI 10.1038/oby.2007.66
   Johannessen L, 2006, J AFFECT DISORDERS, V95, P13, DOI 10.1016/j.jad.2006.03.027
   KEHOE R, 1994, AM J EPIDEMIOL, V139, P813, DOI 10.1093/oxfordjournals.aje.a117078
   Kessler RC, 2004, INT J METH PSYCH RES, V13, P93, DOI 10.1002/mpr.168
   Kessler RC, 2004, INT J METH PSYCH RES, V13, P60, DOI 10.1002/mpr.166
   Kessler RC, 2004, INT J METH PSYCH RES, V13, P69, DOI 10.1002/mpr.167
   Kessler RC, 2003, JAMA-J AM MED ASSOC, V289, P3095, DOI 10.1001/jama.289.23.3095
   Kessler RC, 2006, J AFFECT DISORDERS, V96, P259, DOI 10.1016/j.jad.2006.08.018
   Kilbourne AM, 2004, BIPOLAR DISORD, V6, P368, DOI 10.1111/j.1399-5618.2004.00138.x
   Kilbourne AM, 2007, J AFFECT DISORDERS, V102, P145, DOI 10.1016/j.jad.2007.01.006
   Kriegsman DMW, 1996, J CLIN EPIDEMIOL, V49, P1407, DOI 10.1016/S0895-4356(96)00274-0
   Lasser K, 2000, JAMA-J AM MED ASSOC, V284, P2606, DOI 10.1001/jama.284.20.2606
   Laursen TM, 2007, J CLIN PSYCHIAT, V68, P899, DOI 10.4088/JCP.v68n0612
   Lespérance F, 2000, ARCH INTERN MED, V160, P1354, DOI 10.1001/archinte.160.9.1354
   McElroy SL, 2002, J CLIN PSYCHIAT, V63, P207, DOI 10.4088/JCP.v63n0306
   McIntyre RS, 2006, CAN J PSYCHIAT, V51, P274, DOI 10.1177/070674370605100502
   Merikangas KR, 2007, CURR OPIN PSYCHIATR, V20, P353, DOI 10.1097/YCO.0b013e3281c61dc5
   Meyer CM, 2004, J AFFECT DISORDERS, V83, P127, DOI 10.1016/j.jad.2004.06.004
   Mezuk B, 2008, AM J PUBLIC HEALTH, V98, P1480, DOI 10.2105/AJPH.2007.126441
   Morris CD, 2006, PSYCHIAT SERV, V57, P1035, DOI 10.1176/appi.ps.57.7.1035
   Murray DP, 2009, CURR PSYCHIAT REP, V11, P475, DOI 10.1007/s11920-009-0072-3
   Ogden CL, 2006, JAMA-J AM MED ASSOC, V295, P1549, DOI 10.1001/jama.295.13.1549
   Onyike CU, 2003, AM J EPIDEMIOL, V158, P1139, DOI 10.1093/aje/kwg275
   Ormel J, 1997, PSYCHOL MED, V27, P1065, DOI 10.1017/S0033291797005321
   Ormel J, 2007, GEN HOSP PSYCHIAT, V29, P325, DOI 10.1016/j.genhosppsych.2007.03.009
   Ösby U, 2001, ARCH GEN PSYCHIAT, V58, P844, DOI 10.1001/archpsyc.58.9.844
   Parker GB, 2008, BIOL PSYCHIAT, V64, P660, DOI 10.1016/j.biopsych.2008.05.021
   Patten SB, 2008, GEN HOSP PSYCHIAT, V30, P407, DOI 10.1016/j.genhosppsych.2008.05.001
   Penninx BWJH, 1996, J PSYCHOSOM RES, V40, P521, DOI 10.1016/0022-3999(95)00620-6
   Phillips AC, 2009, PSYCHOSOM MED, V71, P395, DOI 10.1097/PSY.0b013e31819e6706
   Rutledge T, 2006, ARCH GEN PSYCHIAT, V63, P874, DOI 10.1001/archpsyc.63.8.874
   Scott KM, 2008, INT J OBESITY, V32, P192, DOI 10.1038/sj.ijo.0803701
   Scott KM, 2007, J AFFECT DISORDERS, V103, P113, DOI 10.1016/j.jad.2007.01.015
   Shah Amy, 2006, Ann Clin Psychiatry, V18, P239, DOI 10.1080/10401230600948423
   SHARMA R, 1994, J AFFECT DISORDERS, V31, P91, DOI 10.1016/0165-0327(94)90112-0
   Shibeshi WA, 2007, J AM COLL CARDIOL, V49, P2021, DOI 10.1016/j.jacc.2007.03.007
   Simon GE, 2006, ARCH GEN PSYCHIAT, V63, P824, DOI 10.1001/archpsyc.63.7.824
   Smoller JW, 2007, ARCH GEN PSYCHIAT, V64, P1153, DOI 10.1001/archpsyc.64.10.1153
   Stansfeld SA, 2002, INT J EPIDEMIOL, V31, P248, DOI 10.1093/ije/31.1.248
   TRETLI S, 1982, J EPIDEMIOL COMMUN H, V36, P269, DOI 10.1136/jech.36.4.269
   TSUANG MT, 1980, BRIT J PSYCHIAT, V136, P239, DOI 10.1192/bjp.136.3.239
   Watkins LL, 2006, PSYCHOSOM MED, V68, P651, DOI 10.1097/01.psy.0000228342.53606.b3
   WEEKE A, 1986, J AFFECT DISORDERS, V11, P227, DOI 10.1016/0165-0327(86)90074-1
   WEEKE A, 1987, J AFFECT DISORDERS, V13, P287, DOI 10.1016/0165-0327(87)90049-8
   WEINER M, ANN CLIN PS IN PRESS
   WEISSMAN MM, 1990, AM J PSYCHIAT, V147, P1504
   White MA, 2007, OBESITY, V15, P2761, DOI 10.1038/oby.2007.328
   Yates WR, 2004, GEN HOSP PSYCHIAT, V26, P421, DOI 10.1016/j.genhosppsych.2004.06.008
   YATES WR, 1987, J AFFECT DISORDERS, V12, P129, DOI 10.1016/0165-0327(87)90004-8
   Yun S, 2006, INT J OBESITY, V30, P164, DOI 10.1038/sj.ijo.0803125
NR 70
TC 73
Z9 90
U1 0
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD FEB
PY 2011
VL 70
IS 2
BP 145
EP 154
DI 10.1016/j.jpsychores.2010.07.010
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 716ET
UT WOS:000286952600006
PM 21262417
OA Green Accepted
DA 2025-06-11
ER

PT S
AU Lin, KG
   Liu, T
AF Lin, Kangguang
   Liu, Tao
BE Yau, SY
   So, KF
TI Exercise on bipolar disorder in humans
SO EXERCISE ON BRAIN HEALTH
SE International Review of Neurobiology
LA English
DT Review; Book Chapter
ID PHYSICAL-ACTIVITY; SEDENTARY BEHAVIOR; PERCEIVED BARRIERS;
   MENTAL-ILLNESS; PEOPLE; DEPRESSION; MORTALITY; SCHIZOPHRENIA;
   INTERVENTIONS; ASSOCIATION
AB People with Bipolar disorder (BD) often have a sedentary lifestyle and low level of physical activity which in part contribute to the high co-occurrence of medical diseases including cardiovascular disease, type 2 diabetes, and metabolic syndrome, etc. Exercise especially aerobic exercise may be beneficial not only to mental health but also physical health outcomes. Targeting barriers for exercise such as high BMI and making the best use of facilitators (e.g., concept of fitness) can result in higher levels of exercise engagement in people with BD.
C1 [Lin, Kangguang; Liu, Tao] Guangzhou Med Univ, Dept Mood Disorders, Affiliated Brain Hosp, Guangzhou, Guangdong, Peoples R China.
C3 Guangzhou Medical University
RP Lin, KG (corresponding author), Guangzhou Med Univ, Dept Mood Disorders, Affiliated Brain Hosp, Guangzhou, Guangdong, Peoples R China.
EM linkangguang@163.com
CR Melo MCA, 2019, J AFFECT DISORDERS, V251, P100, DOI 10.1016/j.jad.2019.03.061
   Aune D, 2015, EUR J EPIDEMIOL, V30, P529, DOI 10.1007/s10654-015-0056-z
   Carpiniello B, 2013, J MENT HEALTH, V22, P492, DOI 10.3109/09638237.2013.815330
   Chin SH, 2016, OBES REV, V17, P1226, DOI 10.1111/obr.12460
   Crump C, 2013, JAMA PSYCHIAT, V70, P931, DOI 10.1001/jamapsychiatry.2013.1394
   Depp CA, 2016, PSYCHIAT CLIN N AM, V39, P95, DOI 10.1016/j.psc.2015.09.004
   Firth J, 2016, BMC PSYCHIATRY, V16, DOI 10.1186/s12888-016-0751-7
   Forty L, 2014, BRIT J PSYCHIAT, V205, P465, DOI 10.1192/bjp.bp.114.152249
   Gaubil I., 2012, ENCEPHALE, V38, P167
   Gershon A, 2016, CLIN PSYCHOL SCI, V4, P641, DOI 10.1177/2167702615604613
   Harvey SB, 2018, AM J PSYCHIAT, V175, P28, DOI 10.1176/appi.ajp.2017.16111223
   Hu G, 2005, DIABETES CARE, V28, P799, DOI 10.2337/diacare.28.4.799
   Janney CA, 2014, J AFFECT DISORDERS, V152, P498, DOI 10.1016/j.jad.2013.09.009
   Kessing LV, 2015, J AFFECT DISORDERS, V180, P142, DOI 10.1016/j.jad.2015.03.027
   Kilbourne AM, 2007, BIPOLAR DISORD, V9, P443, DOI 10.1111/j.1399-5618.2007.00386.x
   Knapen J, 2015, DISABIL REHABIL, V37, P1490, DOI 10.3109/09638288.2014.972579
   Kucyi A, 2010, POSTGRAD MED, V122, P107, DOI 10.3810/pgm.2010.11.2228
   Kupchik YM, 2017, NEUROPSYCHOPHARMACOL, V42, P369, DOI 10.1038/npp.2016.160
   Lanier JB, 2016, AM FAM PHYSICIAN, V93, P919
   Lima IMM, 2018, CLIN PSYCHOL REV, V59, P126, DOI 10.1016/j.cpr.2017.11.006
   Lomholt LH, 2019, INT J BIPOLAR DISORD, V7, DOI 10.1186/s40345-018-0140-x
   MacIntosha BJ, 2017, J AFFECT DISORDERS, V208, P205, DOI 10.1016/j.jad.2016.08.060
   Metcalfe AWS, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.85
   Muralidharan A, 2018, PSYCHIATR REHABIL J, V41, P67, DOI 10.1037/prj0000245
   Naci H, 2015, BRIT J SPORT MED, V49, P1414, DOI 10.1136/bjsports-2015-f5577rep
   Nakamura A, 2019, J AFFECT DISORDERS, V246, P29, DOI 10.1016/j.jad.2018.12.009
   Ng F, 2007, J AFFECT DISORDERS, V101, P259, DOI 10.1016/j.jad.2006.11.014
   Northey JM, 2018, BRIT J SPORT MED, V52, P154, DOI 10.1136/bjsports-2016-096587
   Parks J., 2006, Morbidity and mortality in people with serious mental illness
   Pereira S, 2019, COMUNICAR, V27, P41, DOI 10.3916/C58-2019-04
   Rosenbaum S, 2014, J CLIN PSYCHIAT, V75, P964, DOI 10.4088/JCP.13r08765
   Schuch FB, 2018, AM J PSYCHIAT, V175, P631, DOI 10.1176/appi.ajp.2018.17111194
   Schuch FB, 2015, PSYCHIAT RES, V229, P57, DOI 10.1016/j.psychres.2015.07.072
   Shah A, 2007, J AFFECT DISORDERS, V104, P191, DOI 10.1016/j.jad.2007.03.002
   Sherwood NE, 2000, ANNU REV NUTR, V20, P21, DOI 10.1146/annurev.nutr.20.1.21
   Shou H, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/tp.2017.136
   Soundy A, 2014, PSYCHIAT RES, V220, P11, DOI 10.1016/j.psychres.2014.07.083
   Stubbs B, 2018, EUR PSYCHIAT, V54, P124, DOI 10.1016/j.eurpsy.2018.07.004
   Stubbs B, 2016, J AFFECT DISORDERS, V190, P249, DOI 10.1016/j.jad.2015.10.010
   Subramaniapillai M, 2016, J AFFECT DISORDERS, V190, P467, DOI 10.1016/j.jad.2015.10.018
   Sylvia LG, 2019, J AFFECT DISORDERS, V250, P278, DOI 10.1016/j.jad.2019.03.033
   Sylvia LG, 2013, INT J BIPOLAR DISORD, V1, DOI 10.1186/2194-7511-1-24
   Sylvia LG, 2013, J AFFECT DISORDERS, V151, P722, DOI 10.1016/j.jad.2013.07.031
   Sylvia LG, 2011, J PSYCHIATR PRACT, V17, P224, DOI 10.1097/01.pra.0000398419.82362.32
   Thomson D, 2015, FRONT PSYCHOL, V6, DOI 10.3389/fpsyg.2015.00147
   Vancampfort D, 2017, WORLD PSYCHIATRY, V16, P308, DOI 10.1002/wps.20458
   Vancampfort D, 2016, J AFFECT DISORDERS, V201, P145, DOI 10.1016/j.jad.2016.05.020
   Vancampfort D, 2015, PSYCHIAT RES, V229, P194, DOI 10.1016/j.psychres.2015.07.040
   Vancampfort D, 2013, J AFFECT DISORDERS, V145, P285, DOI 10.1016/j.jad.2012.07.020
   Wright K, 2012, J AFFECT DISORDERS, V136, P634, DOI 10.1016/j.jad.2011.10.017
   Wu PL, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0181515
NR 51
TC 7
Z9 7
U1 1
U2 7
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0074-7742
BN 978-0-12-816967-4
J9 INT REV NEUROBIOL
JI Int. Rev. Neurobiol.
PY 2019
VL 147
BP 189
EP 198
DI 10.1016/bs.irn.2019.07.001
PG 10
WC Neurosciences
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA BO1NS
UT WOS:000501593500008
PM 31607354
DA 2025-06-11
ER

PT J
AU Rebolledo-Solleiro, D
   Roldán-Roldán, G
   Díaz, D
   Velasco, M
   Larqué, C
   Rico-Rosillo, G
   Vega-Robledo, GB
   Zambrano, E
   Hiriart, M
   de la Mora, MP
AF Rebolledo-Solleiro, Daniela
   Roldan-Roldan, Gabriel
   Diaz, Daniel
   Velasco, Myrian
   Larque, Carlos
   Rico-Rosillo, Guadalupe
   Bertha Vega-Robledo, Gloria
   Zambrano, Elena
   Hiriart, Marcia
   Perez de la Mora, Miguel
TI Increased anxiety-like behavior is associated with the metabolic
   syndrome in non-stressed rats
SO PLOS ONE
LA English
DT Article
ID ELEVATED PLUS-MAZE; DEPRESSIVE-LIKE BEHAVIOR; CHRONIC STRESS;
   INDOLEAMINE 2,3-DIOXYGENASE; LEPTIN RESISTANCE; GUT MICROBIOTA; OBESITY;
   DIET; BRAIN; AMYGDALA
AB Metabolic syndrome (MS) is a cluster of signs that increases the risk to develop diabetes mellitus type 2 and cardiovascular disease. In the last years, a growing interest to study the relationship between MS and psychiatric disorders, such as depression and anxiety, has emerged obtaining conflicting results. Diet-induced MS rat models have only examined the effects of high-fat or mixed cafeteria diets to a limited extent. We explored whether an anxiety-like behavior was associated with MS in non-stressed rats chronically submitted to a high-sucrose diet (20% sucrose in drinking water) using three different anxiety paradigms: the shock-probe/burying test (SPBT), the elevated plus-maze (EPM) and the open-field test (OFT). Behaviorally, the high-sucrose diet group showed an increase in burying behavior in the SPBT. Also, these animals displayed both avoidance to explore the central part of the arena and a significant increase in freezing behavior in the OFT and lack of effects in the EPM. Also, high-sucrose diet group showed signs of an MS-like condition: significant increases in body weight and body mass index, abdominal obesity, hypertension, hyperglycemia, hyperinsulinemia, and dyslipidemia. Plasma leptin and resistin levels were also increased. No changes in plasma corticosterone levels were found. These results indicate that rats under a 24-weeks high-sucrose diet develop an MS associated with an anxiety-like behavior. Although the mechanisms underlying this behavioral outcome remain to be investigated, the role of leptin is emphasized.
C1 [Rebolledo-Solleiro, Daniela; Velasco, Myrian; Larque, Carlos; Hiriart, Marcia; Perez de la Mora, Miguel] Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Div Neurosci, Mexico City, DF, Mexico.
   [Roldan-Roldan, Gabriel] Univ Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Lab Neurobiol Conducta, Mexico City, DF, Mexico.
   [Diaz, Daniel] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Biol Cell & Fisiol, Mexico City, DF, Mexico.
   [Rico-Rosillo, Guadalupe; Bertha Vega-Robledo, Gloria] Univ Nacl Autonoma Mexico, Lab Inmunol, Dept Med Expt, Fac Med, Mexico City, DF, Mexico.
   [Zambrano, Elena] Inst Nacl Nutr Salvador Zubiran, Dept Biol Reprod, Mexico City, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma
   de Mexico; Universidad Nacional Autonoma de Mexico; Universidad Nacional
   Autonoma de Mexico; Instituto Nacional de Ciencias Medicas y Nutricion
   Salvador Zubiran - Mexico
RP Rebolledo-Solleiro, D; de la Mora, MP (corresponding author), Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Div Neurosci, Mexico City, DF, Mexico.
EM danyrebolledo@hotmail.com; mperez@ifc.unam.mx
RI Larqué, Carlos/B-3834-2011; Diaz, Daniel/P-1916-2018; Hiriart,
   Marcia/A-3988-2008
OI Zambrano, Elena/0000-0002-0362-9117; Diaz, Daniel/0000-0003-2302-1982;
   Velasco, Myrian/0000-0002-9276-1928; Hiriart,
   Marcia/0000-0001-5711-8868; Larque Velazquez, Carlos
   Alfonso/0000-0003-0634-195X; REBOLLEDO-SOLLEIRO,
   DANIELA/0000-0002-6994-7599; Perez de la Mora,
   Miguel/0000-0003-1520-4439
FU Direccio An General de Asuntos del Personal AcadeAmico, (DGAPA)
   [IN204314, IN204014-3]; Universidad Nacional Autonoma de Mexico (UNAM);
   Consejo Nacional de Cienciay Tecnologia (CONACyT) [CB-2013/220173]
FX This study was supported in part by grants IN204314 and IN204014-3 from
   Direccion General de Asuntos del Personal Academico, (DGAPA),
   Universidad Nacional Autonoma de Mexico (UNAM) and by grant
   CB-2013/220173 from Consejo Nacional de Ciencia y Tecnologia (CONACyT),
   as well as the one given to D.R-S during her graduate studies within the
   program of Doctorado en Ciencias Biomedicas from the Universidad
   Nacional Autonoma de Mexico (UNAM).
CR Albert U, 2013, GEN HOSP PSYCHIAT, V35, P154, DOI 10.1016/j.genhosppsych.2012.10.004
   André C, 2014, BRAIN BEHAV IMMUN, V41, P10, DOI 10.1016/j.bbi.2014.03.012
   [Anonymous], NUTR NEUROSCI
   Ari M, 2012, J AFFECT DISORDERS, V136, P979, DOI 10.1016/j.jad.2011.07.029
   Arnold M, 2010, PHYSIOL BEHAV, V99, P592, DOI 10.1016/j.physbeh.2010.01.021
   Asakawa A, 2003, J DIABETES COMPLICAT, V17, P27, DOI 10.1016/S1056-8727(02)00198-8
   Aydin S, 2014, NUTRITION, V30, P1, DOI 10.1016/j.nut.2013.05.013
   Bananej M, 2012, J PSYCHOPHARMACOL, V26, P564, DOI 10.1177/0269881111405556
   BECKNIELSEN H, 1980, AM J CLIN NUTR, V33, P273, DOI 10.1093/ajcn/33.2.273
   Bendtsen KMB, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046231
   Brunetti L, 2004, EUR J PHARMACOL, V493, P41, DOI 10.1016/j.ejphar.2004.04.020
   Caro JF, 1996, LANCET, V348, P159, DOI 10.1016/S0140-6736(96)03173-X
   Carroll D, 2009, BIOL PSYCHIAT, V66, P91, DOI 10.1016/j.biopsych.2009.02.020
   Chen K, 2006, NAT MED, V12, P425, DOI 10.1038/nm1372
   Chepulis LM, 2009, PHYSIOL BEHAV, V97, P359, DOI 10.1016/j.physbeh.2009.03.001
   Claesson MJ, 2012, NATURE, V488, P178, DOI 10.1038/nature11319
   Clemente JC, 2012, CELL, V148, P1258, DOI 10.1016/j.cell.2012.01.035
   CORODIMAS KP, 1994, ANN NY ACAD SCI, V746, P392
   Dallman MF, 2003, P NATL ACAD SCI USA, V100, P11696, DOI 10.1073/pnas.1934666100
   Day Caroline, 2007, Diab Vasc Dis Res, V4, P32, DOI 10.3132/dvdr.2007.003
   De Boer SF, 2003, EUR J PHARMACOL, V463, P145, DOI 10.1016/S0014-2999(03)01278-0
   de Cossio LF, 2016, BRAIN BEHAV IMMUNITY
   de la Mora MP, 2005, NEUROSCI LETT, V377, P101, DOI 10.1016/j.neulet.2004.11.079
   Dinel AL, 2014, PSYCHONEUROENDOCRINO, V40, P48, DOI 10.1016/j.psyneuen.2013.10.014
   Dinel AL, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024325
   Ding WJ, 2014, ARCH IRAN MED, V17, P563, DOI 014178/AIM.008
   Fernández-Guasti A, 2001, PHARMACOL BIOCHEM BE, V70, P85, DOI 10.1016/S0091-3057(01)00586-X
   Finger BC, 2011, NEUROSCIENCE, V192, P351, DOI 10.1016/j.neuroscience.2011.06.072
   Finger BC, 2010, PSYCHOPHARMACOLOGY, V210, P559, DOI 10.1007/s00213-010-1858-z
   Foster JA, 2013, TRENDS NEUROSCI, V36, P305, DOI 10.1016/j.tins.2013.01.005
   Francis H, 2013, APPETITE, V63, P119, DOI 10.1016/j.appet.2012.12.018
   Gancheva Silvia M, 2016, Folia Med (Plovdiv), V58, P264, DOI 10.1515/folmed-2016-0032
   Geurts L, 2011, FRONT MICROBIOL, V2, DOI 10.3389/fmicb.2011.00149
   Gonzalez LE, 1997, J NEUROSCI, V17, P1505
   Hånell A, 2014, FRONT BEHAV NEUROSCI, V8, DOI 10.3389/fnbeh.2014.00252
   Hascoet M, 1997, PHARMACOL BIOCHEM BE, V58, P1131, DOI 10.1016/S0091-3057(97)00093-2
   Hildrum B, 2009, ACTA PSYCHIAT SCAND, V120, P14, DOI 10.1111/j.1600-0447.2008.01315.x
   Hryhorczuk C, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00177
   Jorgensen BP, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0103398
   Kurhe Y, 2015, PHARMACOL BIOCHEM BE, V136, P107, DOI 10.1016/j.pbb.2015.07.004
   Kurhe Y, 2015, BIOCHEM BIOPH RES CO, V456, P74, DOI 10.1016/j.bbrc.2014.11.036
   Larqué C, 2011, IUBMB LIFE, V63, P831, DOI 10.1002/iub.544
   Levin BE, 2002, AM J PHYSIOL-REG I, V283, pR941, DOI 10.1152/ajpregu.00245.2002
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Linnville S, 2011, MIL MED, V176, P369, DOI 10.7205/MILMED-D-10-00367
   Liu J, 2010, PSYCHOPHARMACOLOGY, V207, P535, DOI 10.1007/s00213-009-1684-3
   Luna RA, 2015, CURR OPIN BIOTECH, V32, P35, DOI 10.1016/j.copbio.2014.10.007
   Matheny M, 2011, NEUROPHARMACOLOGY, V60, P480, DOI 10.1016/j.neuropharm.2010.11.002
   McEwen BS, 2004, ANN NY ACAD SCI, V1032, P1, DOI 10.1196/annals.1314.001
   Morganstern I, 2012, BRAIN RES, V1470, P24, DOI 10.1016/j.brainres.2012.06.004
   Morris M. J., 2015, Neuroscience and Biobehavioral Reviews, V58, P36, DOI 10.1016/j.neubiorev.2014.12.002
   Owecki M, 2011, EXP CLIN ENDOCR DIAB, V119, P117, DOI 10.1055/s-0030-1263111
   Pape HC, 2010, PHYSIOL REV, V90, P419, DOI 10.1152/physrev.00037.2009
   Pecoraro N, 2004, ENDOCRINOLOGY, V145, P3754, DOI 10.1210/en.2004-0305
   PELLOW S, 1985, J NEUROSCI METH, V14, P149, DOI 10.1016/0165-0270(85)90031-7
   de la Mora MP, 2012, NEUROSCIENCE, V201, P252, DOI 10.1016/j.neuroscience.2011.10.045
   Pezze MA, 2004, PROG NEUROBIOL, V74, P301, DOI 10.1016/j.pneurobio.2004.09.004
   Prasad A, 1996, PHYSIOL BEHAV, V60, P1039, DOI 10.1016/0031-9384(96)00135-7
   Prut L, 2003, EUR J PHARMACOL, V463, P3, DOI 10.1016/S0014-2999(03)01272-X
   Rajala MW, 2003, J CLIN INVEST, V111, P225, DOI 10.1172/JCI200316521
   Rebolledo-Solleiro D, 2016, BEHAV BRAIN RES, V313, P293, DOI 10.1016/j.bbr.2016.06.060
   Reddy BR, 2016, J BIOSCIENCES, V41, P407, DOI 10.1007/s12038-016-9627-8
   Reyes-Castro LA, 2012, BEHAV BRAIN RES, V227, P324, DOI 10.1016/j.bbr.2011.06.008
   RODGERS RJ, 1993, PSYCHOPHARMACOLOGY, V113, P237, DOI 10.1007/BF02245704
   Roozendaal B, 1996, PSYCHONEUROENDOCRINO, V21, P681, DOI 10.1016/S0306-4530(96)00028-5
   Sadashiv, 2012, WORLD J DIABETES, V3, P135, DOI 10.4239/wjd.v3.i7.135
   Schwartz DR, 2011, TRENDS ENDOCRIN MET, V22, P259, DOI 10.1016/j.tem.2011.03.005
   SENSI M, 1991, DIABETES RES CLIN EX, V16, P1
   Sharma S, 2013, INT J OBESITY, V37, P1183, DOI 10.1038/ijo.2012.197
   Sharma S, 2013, INT J OBESITY, V37, P382, DOI 10.1038/ijo.2012.48
   Shepard JD, 2000, BRAIN RES, V861, P288, DOI 10.1016/S0006-8993(00)02019-9
   Stanhope KL, 2012, ANNU REV MED, V63, P329, DOI 10.1146/annurev-med-042010-113026
   Steppan CM, 2001, NATURE, V409, P307, DOI 10.1038/35053000
   Tang F, 2017, PSYCHONEUROENDOCRINO, V77, P112, DOI 10.1016/j.psyneuen.2016.11.025
   Tannenbaum BM, 1997, AM J PHYSIOL-ENDOC M, V273, pE1168, DOI 10.1152/ajpendo.1997.273.6.E1168
   Teegarden SL, 2007, BIOL PSYCHIAT, V61, P1021, DOI 10.1016/j.biopsych.2006.09.032
   TREIT D, 1990, PHARMACOL BIOCHEM BE, V36, P203, DOI 10.1016/0091-3057(90)90151-7
   Velasco M, 2012, ISLETS, V4, P302, DOI 10.4161/isl.21374
   Weiss T, 2011, GEN HOSP PSYCHIAT, V33, P135, DOI 10.1016/j.genhosppsych.2011.01.002
   Yamada N, 2011, ENDOCRINOLOGY, V152, P2634, DOI 10.1210/en.2011-0004
   Zhang Y, 2006, PHYSIOL BEHAV, V88, P249, DOI 10.1016/j.physbeh.2006.05.038
NR 81
TC 34
Z9 35
U1 1
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 2
PY 2017
VL 12
IS 5
AR e0176554
DI 10.1371/journal.pone.0176554
PG 21
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA ET9RV
UT WOS:000400646300032
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Roer, GE
   Lien, LR
   Bolstad, I
   Aaseth, JO
   Abebe, DS
AF Roer, Grethe Emilie
   Lien, Lars
   Bolstad, Ingeborg
   Aaseth, Jan O.
   Abebe, Dawit Shawel
TI The impact of PTSD on risk of cardiometabolic diseases: a national
   patient cohort study in Norway
SO BMC PSYCHIATRY
LA English
DT Article
DE Posttraumatic stress disorder; Alcohol use disorder; Depression;
   Comorbidity; Cardiovascular diseases; Metabolic diseases; Diabetes
   mellitus; Epidemiology; Register data; Cohort study
ID POSTTRAUMATIC-STRESS-DISORDER; MAJOR DEPRESSIVE DISORDER;
   PHYSICAL-ACTIVITY LEVELS; SUBSTANCE USE DISORDERS; METABOLIC SYNDROME;
   EPIDEMIOLOGIC SURVEY; PEOPLE; PREVALENCE; HEALTH; ASSOCIATION
AB BackgroundPosttraumatic stress disorder (PTSD) is associated with cardiometabolic diseases, concurrent anxiety, alcohol use disorder and depression. The relationship between PTSD and cardiometabolic diseases are still unclear, and less is known about the effects of socioeconomic status, comorbid anxiety, comorbid alcohol use disorder and comorbid depression. The study, therefore, aims to examine the risk of developing cardiometabolic diseases including type 2 diabetes mellitus over time in PTSD patients, and to what extent socioeconomic status, comorbid anxiety, comorbid alcohol use disorder and comorbid depression attenuate associations between PTSD and risk of developing cardiometabolic diseases.MethodA retrospective, register-based cohort study with 6-years follow-up of adult (> 18 years) PTSD patients (N = 7 852) compared with the general population (N = 4 041 366), was performed. Data were acquired from the Norwegian Patient Registry and Statistic Norway. Cox proportional regression models were applied to estimate hazard ratios (HRs) (99% confidence intervals) of cardiometabolic diseases among PTSD patients.ResultsSignificantly (p < 0.001) higher age and gender adjusted HRs were disclosed for all cardiometabolic diseases among PTSD patients compared to the population without PTSD, with a variation in HR from 3.5 (99% CI 3.1-3.9) for hypertensive diseases to HR = 6.5 (5.7-7.5) for obesity. When adjusted for socioeconomic status and comorbid mental disorders, reductions were observed, especially for comorbid depression, for which the adjustment resulted in HR reduction of about 48.6% for hypertensive diseases and 67.7% for obesity.ConclusionsPTSD was associated with increased risk of developing cardiometabolic diseases, though attenuated by socioeconomic status and comorbid mental disorders. Health care professionals should be attentive towards the burden and increased risk that low socioeconomic status and comorbid mental disorders may represent for PTSD patients' cardiometabolic health.
C1 [Roer, Grethe Emilie; Lien, Lars; Abebe, Dawit Shawel] Innlandet Hosp Trust, Norwegian Natl Advisory Unit Concurrent Subst Abus, POB 104, NO-2381 Brumunddal, Norway.
   [Roer, Grethe Emilie; Abebe, Dawit Shawel] Oslo Metropolitan Univ, Dept Nursing & Hlth Promot, St Olavs Plass,POB 4, NO-0130 Oslo, Norway.
   [Lien, Lars; Bolstad, Ingeborg; Aaseth, Jan O.] Inland Norway Univ Appl Sci, Fac Social & Hlth Sci, POB 400, NO-2418 Elverum, Norway.
   [Aaseth, Jan O.] Innlandet Hosp Trust, Res Dept, POB 104, NO-2381 Brumunddal, Norway.
C3 Innlandet Hospital Trust; Oslo Metropolitan University (OsloMet); Inland
   Norway University of Applied Sciences; Innlandet Hospital Trust
RP Roer, GE (corresponding author), Innlandet Hosp Trust, Norwegian Natl Advisory Unit Concurrent Subst Abus, POB 104, NO-2381 Brumunddal, Norway.; Roer, GE (corresponding author), Oslo Metropolitan Univ, Dept Nursing & Hlth Promot, St Olavs Plass,POB 4, NO-0130 Oslo, Norway.
EM grethe.emilie.roer@sykehuset-innlandet.no
RI Aaseth, Jan/J-6764-2017
OI Roer, Grethe Emilie/0000-0002-7237-6715; Bolstad,
   Ingeborg/0000-0001-7316-6309
CR Aaseth J, 2019, BIOMED PHARMACOTHER, V117, DOI 10.1016/j.biopha.2019.108834
   Abebe DS, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2021-050608
   Akosile W, 2018, AUSTRALAS PSYCHIATRY, V26, P524, DOI 10.1177/1039856218789779
   Alonso J, 2004, ACTA PSYCHIAT SCAND, V109, P47
   [Anonymous], 1992, The ICD-10 classification of mental and behavioural disorders: Clinical descriptions and diagnostic guidelines
   Aschbacher K, 2014, PSYCHONEUROENDOCRINO, V46, P14, DOI 10.1016/j.psyneuen.2014.04.003
   Bao AM, 2008, BRAIN RES REV, V57, P531, DOI 10.1016/j.brainresrev.2007.04.005
   Bartoli F, 2015, METABOLISM, V64, P1373, DOI 10.1016/j.metabol.2015.07.017
   Batelaan NM, 2016, BRIT J PSYCHIAT, V208, P223, DOI 10.1192/bjp.bp.114.156554
   Celano CM, 2016, CURR PSYCHIAT REP, V18, DOI 10.1007/s11920-016-0739-5
   Crum-Cianflone NF, 2014, CIRCULATION, V129, P1813, DOI 10.1161/CIRCULATIONAHA.113.005407
   da Silva HC, 2019, BRAZ J PSYCHIAT, V41, P213, DOI 10.1590/1516-4446-2017-0025
   de Matos MB, 2018, REV BRAS PSIQUIATR, V40, P349, DOI 10.1590/1516-4446-2017-2258
   Dedert EA, 2010, ANN BEHAV MED, V39, P61, DOI 10.1007/s12160-010-9165-9
   Guidi J, 2020, PSYCHOTHER PSYCHOSOM, V90, P11, DOI 10.1159/000510696
   Haneuse S, 2019, JAMA-J AM MED ASSOC, V321, P602, DOI 10.1001/jama.2018.21554
   Hasin DS, 2007, ARCH GEN PSYCHIAT, V64, P830, DOI 10.1001/archpsyc.64.7.830
   Jacobsen LK, 2001, AM J PSYCHIAT, V158, P1184, DOI 10.1176/appi.ajp.158.8.1184
   Kelly PJ, 2012, DRUG ALCOHOL REV, V31, P638, DOI 10.1111/j.1465-3362.2012.00465.x
   Koenen KC, 2017, PSYCHOL MED, V47, P2260, DOI 10.1017/S0033291717000708
   Koenen KC, 2017, PSYCHOL MED, V47, P209, DOI [10.1017/s0033291716002294, 10.1017/S0033291716002294]
   Konttinen H, 2010, APPETITE, V54, P473, DOI 10.1016/j.appet.2010.01.014
   Lohr JB, 2015, AM J GERIAT PSYCHIAT, V23, P709, DOI 10.1016/j.jagp.2015.04.001
   Loyland B, 2021, SCAND J PUBLIC HEALT, V49, P865, DOI 10.1177/1403494820939812
   Lukaschek K, 2013, J PSYCHOSOM RES, V74, P340, DOI 10.1016/j.jpsychores.2012.12.011
   Mackenbach JP, 2008, NEW ENGL J MED, V358, P2468, DOI 10.1056/NEJMsa0707519
   McCaffery JM, 2006, PSYCHOSOM MED, V68, P187, DOI 10.1097/01.psy.0000208630.79271.a0
   MCEWEN BS, 1993, ARCH INTERN MED, V153, P2093, DOI 10.1001/archinte.153.18.2093
   Nesvåg R, 2017, BMC PSYCHIATRY, V17, DOI 10.1186/s12888-017-1256-8
   Otto MW, 2018, CLIN PSYCHOL-SCI PR, V25, DOI 10.1111/cpsp.12253
   Pacella ML, 2013, J ANXIETY DISORD, V27, P33, DOI 10.1016/j.janxdis.2012.08.004
   Piano MR, 2017, ALCOHOL RES-CURR REV, V38, P219
   Rad N., 2014, NORDIC NUTR RECOMMEN
   Regitz-Zagrosek V, 2006, CLIN RES CARDIOL, V95, P136, DOI 10.1007/s00392-006-0351-5
   Ringard Å, 2013, HEALT SYST TRANSIT, V15, P1
   Roer GE, 2021, J EAT DISORD, V9, DOI 10.1186/s40337-021-00480-y
   Rosenbaum S, 2015, METABOLISM, V64, P926, DOI [10.1016/j.metabol.2015.04.009, 10.1016/j.metabol.2015.01.016]
   Ryder AL, 2018, CURR PSYCHIAT REP, V20, DOI 10.1007/s11920-018-0977-9
   Rytwinski NK, 2013, J TRAUMA STRESS, V26, P299, DOI 10.1002/jts.21814
   Schultz WM, 2018, CIRCULATION, V137, P2166, DOI 10.1161/CIRCULATIONAHA.117.029652
   Sheerin C, 2016, PSYCHOL ADDICT BEHAV, V30, P771, DOI 10.1037/adb0000185
   Smith SM, 2016, J PSYCHIATR RES, V82, P16, DOI 10.1016/j.jpsychires.2016.06.022
   Textor J, 2016, INT J EPIDEMIOL, V45, P1887, DOI 10.1093/ije/dyw341
   Toft H, 2018, NEUROPSYCH DIS TREAT, V14, P2367, DOI 10.2147/NDT.S173659
   Toftdahl NG, 2016, SOC PSYCH PSYCH EPID, V51, P129, DOI 10.1007/s00127-015-1104-4
   Van der Kooy K, 2007, INT J GERIATR PSYCH, V22, P613, DOI 10.1002/gps.1723
   Vancampfort D, 2019, ALCOHOL, V76, P73, DOI 10.1016/j.alcohol.2018.07.014
   Vancampfort D, 2017, WORLD PSYCHIATRY, V16, P308, DOI 10.1002/wps.20458
   Vancampfort D, 2016, PSYCHOSOM MED, V78, P465, DOI 10.1097/PSY.0000000000000297
   Williams JW, 2019, IMMUNITY, V50, P941, DOI 10.1016/j.immuni.2019.03.007
   World Health Organization and Calouste Gulbenkian Foundation, 2014, SOCIAL DETERMINANTS
NR 51
TC 3
Z9 3
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD MAY 20
PY 2023
VL 23
IS 1
AR 349
DI 10.1186/s12888-023-04866-x
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA G6FO8
UT WOS:000990095200001
PM 37210523
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Clackler, RG
   Felton, KB
   Holmes, SA
   Stabinsky, HN
   Yarbrough, NB
   Burmeister, MA
AF Clackler, Raeleigh G.
   Felton, Kardarius B.
   Holmes, Sarah A.
   Stabinsky, Hailey N.
   Yarbrough, Nicholas B.
   Burmeister, Melissa A.
TI Current and Emerging Therapies for Bipolar Disorder
SO US PHARMACIST
LA English
DT Article
AB Bipolar disorder (BD) is a complex and lifelong mental health disorder characterized by episodes of mania, hypomania, and/or depression. Affected individuals are often diagnosed with comorbidities including metabolic syndrome and substance use disorder, and life expectancy is partly reduced by suicidal ideation. Current pharmacotherapies, many of which were serendipitously discovered, sufficiently target aberrant neurotransmission but yield inadequate outcomes and cause burdensome side effects. Alternative treatments with fewer adverse effects are in development. Some alternative pharmacotherapies entail reappropriation of classic drugs, such as ketamine and scopolamine. Nonpharmacologic treatments help individuals develop coping mechanisms, improve medication adherence, and establish mood -stabilizing social rhythms.
C1 [Clackler, Raeleigh G.; Felton, Kardarius B.; Holmes, Sarah A.; Stabinsky, Hailey N.; Yarbrough, Nicholas B.; Burmeister, Melissa A.] William Carey Univ, Sch Pharm, Dept Pharm, Biloxi, MS 39532 USA.
   [Clackler, Raeleigh G.; Felton, Kardarius B.; Holmes, Sarah A.; Stabinsky, Hailey N.; Yarbrough, Nicholas B.; Burmeister, Melissa A.] William Carey Univ, Sch Pharm, Dept Practice & Pharmaceut Sci, Biloxi, MS 39532 USA.
C3 William Carey University; William Carey University
RP Clackler, RG (corresponding author), William Carey Univ, Sch Pharm, Dept Pharm, Biloxi, MS 39532 USA.; Clackler, RG (corresponding author), William Carey Univ, Sch Pharm, Dept Practice & Pharmaceut Sci, Biloxi, MS 39532 USA.
RI Burmeister, Melissa/GSE-2701-2022
NR 0
TC 0
Z9 0
U1 0
U2 1
PU JOBSON PUBLISHING LLC
PI NEW YORK
PA 100 AVE OF THE AMERICAS, NEW YORK, NY 10013-1678 USA
SN 0148-4818
EI 2331-3501
J9 US PHARM
JI US Pharm.
PD MAY
PY 2024
VL 49
IS 5
PG 77
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA WC6Q2
UT WOS:001252713200008
DA 2025-06-11
ER

PT J
AU Aishwarya, SK
   Gayathri, B
   Prabu, M
   Renuka, P
   Vinodhini, VM
AF Aishwarya, S. K.
   Gayathri, B.
   Prabu, M.
   Renuka, P.
   Vinodhini, V. M.
TI Hypovitaminosis D Implicated in the Development of Stress, Metabolic
   Syndrome and Hepatic Steatosis among Health Science Undergraduates
   attending a Tertiary Care Institute in Tamil Nadu, India
SO JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
LA English
DT Article
DE Body mass index; Fatty liver; Stress score; Vitamin D
ID FATTY LIVER-DISEASE; SERUM 25-HYDROXYVITAMIN D; VITAMIN-D DEFICIENCY;
   ASSOCIATION; PREVALENCE; ADULTS; DEPRESSION; GENDER
AB Introduction: Vitamin D deficiency is prevalent worldwide and its association with stress has become an emerging problem. A collection of linked physiological, biochemical, clinical, and metabolic risk factors is known as the Metabolic Syndrome (MS). High stress level is found associated with vitamin D deficiency and features of metabolic syndrome symptoms.Aim: To estimate the prevalence of vitamin D deficiency, perceived stress, metabolic syndrome and hepatic steatosis among health science Undergraduate (UG) students and also to evaluate the association of vitamin D with percieved stress score, calcium, phosphorus, components of metabolic syndrome and indicators of liver steatosis.Materials and Methods: This cross-sectional study was conducted in SRM Medical College, Hospital and Research Centre, Chennai, India, from February 2022 to August 2022. A total of 80 health science UG students in the age group of 19-25 years were included. The parameters included Fasting plasma glucose, Triglycerides (TGL), High Density Lipoprotein Cholesterol (HDLC), Gamma-glutamyl Transferase (GGT), phosphorus, calcium, and a Perceived Stress Scale (PSS) score scale. Data were statistically analysed using Pearson's correlation test and Receiver Operating Characteristic (ROC) curve was used to assess the relationship of vitamin D with stress, metabolic syndrome and liver steatosis.Results: In the present study, majority 56 (70%) had vitamin D deficiency, 23 (28.75%) had insufficiency and 1 (1.25%) had sufficiency. An estimated 6 (7.5%) of students experienced low stress, 63 (78.75%) experienced moderate stress and 11 (13.75%) experienced high perceived stress. Indicators of metabolic syndrome occurred in 13 (16.25%) of the population. Nearly 6 (7.5%) of the participants displayed manifestation of fatty liver. A negative association was found between vitamin D with stress score, Body Mass Index (BMI), waist circumference, Blood Pressure (BP), phosphorus, fasting plasma glucose, TGL, HDLC, GGT, Fatty Liver Index (FLI) score.Conclusion: In the present study, vitamin D deficiency was most prevalent (70%), followed by metabolic syndrome, high stress and hepatic steatosis. Vitamin D showed a negative correlation with stress score, BMI, waist circumference, BP, phosphorous, fasting plasma glucose, TGL, HDLC, GGT and FLI score.
C1 [Aishwarya, S. K.; Gayathri, B.; Prabu, M.; Renuka, P.; Vinodhini, V. M.] SRMIST, SRM Med Coll Hosp & Res Ctr, Dept Biochem, Chennai, Tamil Nadu, India.
   [Vinodhini, V. M.] SRMIST, SRM Med Coll Hosp & Res Ctr, Dept Biochem, Chennai 603203, Tamilnadu, India.
C3 SRM Institute of Science & Technology Chennai; SRM Institute of Science
   & Technology Chennai
RP Vinodhini, VM (corresponding author), SRMIST, SRM Med Coll Hosp & Res Ctr, Dept Biochem, Chennai 603203, Tamilnadu, India.
EM vinodhiv1@srmist.edu.in
RI vinodhini, v.m/ABE-6875-2021
FU Beckmann Coulter
FX The authors thank Beckmann Coulter for their support.
CR Al Hayek S, 2018, BMC NUTR, V4, DOI 10.1186/s40795-018-0239-6
   Al-Dabhani K, 2017, NUTR DIABETES, V7, DOI 10.1038/nutd.2017.14
   Alkhatatbeh MJ, 2019, LIPIDS HEALTH DIS, V18, DOI 10.1186/s12944-019-0961-3
   Aparna P, 2018, J Family Med Prim Care, V7, P324, DOI 10.4103/jfmpc.jfmpc_78_18
   Asif S, 2020, PAK J MED SCI, V36, P971, DOI 10.12669/pjms.36.5.1873
   Bentley-Lewis R, 2023, NAT REV ENDOCRINOL, V17, pBC07
   Bergmann N, 2014, ENDOCR CONNECT, V3, pR55, DOI 10.1530/EC-14-0031
   Bhatt SP, 2018, BMJ OPEN DIAB RES CA, V6, DOI 10.1136/bmjdrc-2017-000501
   Borges-Canha M, 2021, DIABET METAB SYND OB, V14, P487, DOI 10.2147/DMSO.S286334
   Castellana M, 2021, J CLIN MED, V10, DOI 10.3390/jcm10091877
   Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI 10.1002/hep.29367
   Chang WX, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0154469
   Chaplin TM, 2008, ALCOHOL CLIN EXP RES, V32, P1242, DOI 10.1111/j.1530-0277.2008.00679.x
   Chen L, 2020, NUTRIENTS, V12, DOI 10.3390/nu12071938
   Chhetri B, 2021, J TAIBAH UNIV MED SC, V16, P260, DOI 10.1016/j.jtumed.2020.12.012
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   DeLuca GC, 2013, NEUROPATH APPL NEURO, V39, P458, DOI 10.1111/nan.12020
   Ehrampoush E, 2019, HEPAT MON, V19, DOI 10.5812/hepatmon.92992
   Eliades M, 2015, WORLD J GASTROENTERO, V21, P1718, DOI 10.3748/wjg.v21.i6.1718
   Fu JL, 2019, CLIN NUTR, V38, P2161, DOI 10.1016/j.clnu.2018.08.039
   Gad AI, 2020, EGYPT LIVER J, V10, DOI 10.1186/s43066-020-00033-z
   Garg R, 2018, Int J Reprod Contracept Obstet Gynecol, V7, P2222, DOI [DOI 10.18203/2320-1770.IJRCOG20182324, 10.18203/2320-1770.ijrcog20182324, DOI 10.18203/2320-1770.ijrcog20182324]
   Glueck CJ, 2016, N AM J MED SCI, V8, P284, DOI 10.4103/1947-2714.187137
   Gostner JM, 2020, NEUROPSYCHOBIOLOGY, V79, P89, DOI 10.1159/000496293
   Gracious BL, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-38
   Gwon M, 2016, NUTRIENTS, V8, DOI 10.3390/nu8100647
   Higashiura Y, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-92292-y
   Hoang MT, 2011, MAYO CLIN PROC, V86, P1050, DOI 10.4065/mcp.2011.0208
   Jain V, 2018, INDIAN J MED RES, V148, P291, DOI [10.4103/ijmr.ijmr_1966_16, 10.4103/ijmr.IJMR_1966_16]
   Kader S, 2019, DUBAI MED J, V2, P141, DOI 10.1159/000503899
   Karadeniz Y, 2021, MEDICINA-LITHUANIA, V57, DOI 10.3390/medicina57121297
   Kim MR, 2019, METABOLITES, V9, DOI 10.3390/metabo9070125
   Konstantakis C, 2016, ANN GASTROENTEROL, V29, P297, DOI 10.20524/aog.2016.0037
   Kumar S, 2020, INT J HLTH CLIN RES, V3, P58
   Manappallil RG, 2020, INDIAN J CRIT CARE M, V24, P882, DOI 10.5005/jp-journals-10071-23586
   Manjunath D, 2014, METAB SYNDR RELAT D, V12, P381, DOI 10.1089/met.2014.0003
   Silva MRM, 2021, CLINICS, V76
   Mason Jennifer E, 2010, Prev Cardiol, V13, P36, DOI 10.1111/j.1751-7141.2009.00054.x
   Norman AW, 2008, AM J CLIN NUTR, V88, p491S, DOI 10.1093/ajcn/88.2.491S
   Park JE, 2018, J OBES METAB SYNDR, V27, P223, DOI 10.7570/jomes.2018.27.4.223
   Prasad D S, 2012, J Cardiovasc Dis Res, V3, P204, DOI 10.4103/0975-3583.98895
   Quraishi SA, 2012, CURR OPIN CLIN NUTR, V15, P625, DOI 10.1097/MCO.0b013e328358fc2b
   Rahman AKMS, 2019, JBM, V07, P83
   Ravaioli F, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23169016
   Salari Nader, 2020, Global Health, V16, P57, DOI 10.1186/s12992-020-00589-w
   Sarmiento-Rubiano LA, 2018, J NUTR METAB, V2018, P01
   Schmitt EB, 2018, MATURITAS, V107, P97, DOI 10.1016/j.maturitas.2017.10.011
   Shipton EA, 2015, PAIN RES TREAT, V2015, DOI 10.1155/2015/904967
   Siddiqee MH, 2021, BMC PUBLIC HEALTH, V21, DOI 10.1186/s12889-021-11888-1
   Siyam FF, 2013, CARDIORENAL MED, V3, P232, DOI 10.1159/000355526
   Srimani S, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0188331
   Verma S, 2020, INT J SOC PSYCHIATR, V66, P756, DOI 10.1177/0020764020934508
   Wang CX, 2021, INT J MED SCI, V18, P3280, DOI 10.7150/ijms.62010
   Williams JA, 2016, BMC PREGNANCY CHILDB, V16, DOI 10.1186/s12884-016-0988-7
   Zhou QG, 2008, DIABETES-METAB RES, V24, P459, DOI 10.1002/dmrr.873
NR 55
TC 0
Z9 0
U1 0
U2 0
PU PREMCHAND SHANTIDEVI RESEARCH FOUNDATION
PI DELHI
PA 71 JAIN COLONY, VEER NAGAR, DELHI, 110 007, INDIA
SN 2249-782X
EI 0973-709X
J9 J CLIN DIAGN RES
JI J. Clin. Diagn. Res.
PD MAY
PY 2023
VL 17
IS 5
BP BC7
EP BC12
DI 10.7860/JCDR/2023/60452.17809
PG 6
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA H3OP3
UT WOS:000995096400003
OA gold
DA 2025-06-11
ER

PT J
AU Miglioretti, M
   Meroni, C
   Baiardo, G
   Savioli, G
   Velasco, V
AF Miglioretti, Massimo
   Meroni, Claudia
   Baiardo, Giacomo
   Savioli, Gaia
   Velasco, Veronica
TI The perceptions of the causes of cardiac diseases: a taxonomy
SO PSYCHOLOGY & HEALTH
LA English
DT Article
DE Illness Perception Questionnaire; causal attribution; cardiac diseases;
   illness perception
ID ILLNESS PERCEPTIONS; MYOCARDIAL-INFARCTION; HOSPITAL ANXIETY; COGNITIVE
   REPRESENTATION; DEPRESSION; QUESTIONNAIRE; ATTRIBUTIONS; VALIDATION;
   WORK
AB Objective: This study verifies whether the open-ended question of the B-IPQ can collect causal attributions of patients with cardiac diseases, define the more frequent causal attributions reported, classify them and describe the relation between the classification of the causes and patients' characteristics.Design: A group of 2011 patients with cardiac diseases was recruited during the first week of cardiac rehabilitation.Primary outcome measures: Every participant filled in the B-IPQ and the HADS. The qualitative and quantitative analyses of the text using T-LAB identified the most frequent causal attributions and their co-occurrences.Results: Among the patients, 26% did not recognise any causal attribution. The likelihood that the patients did not provide an answer was increased in older patients, females, patients with lower levels of education and higher levels of depression. Smoking and stress emerged as the most important attributions, followed by genetics, metabolic syndrome, work and nutrition. Four thematic clusters were identified: work and stress', metabolic syndrome and hypertension', displeasures and body care' and heredity and other related diseases'.Conclusions: This study suggests a classification of the causal attributions in patients with cardiac diseases and identifies thematic patterns and unknown attributions. The themes identified can serve as categories for future closed-ended questions.
C1 [Miglioretti, Massimo; Meroni, Claudia; Velasco, Veronica] Univ Milano Bicocca, Dept Psychol, Milan, Italy.
   [Baiardo, Giacomo; Savioli, Gaia] Cardiovasc Inst Camogli, Psychol Unit, Ruta Di Camogli, GE, Italy.
C3 University of Milano-Bicocca
RP Miglioretti, M (corresponding author), Univ Milano Bicocca, Dept Psychol, Milan, Italy.
EM massimo.miglioretti@unimib.it
RI Velasco, Veronica/AAK-2836-2020
OI VELASCO, VERONICA/0000-0003-1890-5564
CR [Anonymous], 2003, SELF REGULATION HLTH
   [Anonymous], 2004, Strumenti per l'analisi dei testi. Introduzione All'uso Di T-LAB
   [Anonymous], 2006, PSICOL SALUT
   Astin Felicity, 2004, J Cardiovasc Nurs, V19, P41
   Baker D, 2007, CLIN PSYCHOL PSYCHOT, V14, P105, DOI 10.1002/cpp.518
   Bellardita L., 2012, NEUROPSYCHOLOGICAL T, V12, P107, DOI [10.7358/neur-2012-012-bell, DOI 10.7358/NEUR-2012-012-BELL]
   Benevene P, 2010, J WORKPLACE LEARN, V22, P508, DOI 10.1108/13665621011082873
   Bennett KK, 2013, J APPL SOC PSYCHOL, V43, P660, DOI 10.1111/jasp.12103
   Blair J, 2014, EUR J CARDIOVASC NUR, V13, P55, DOI 10.1177/1474515113477272
   Brink E, 2011, SCAND J PSYCHOL, V52, P573, DOI 10.1111/j.1467-9450.2011.00901.x
   Broadbent E, 2006, J PSYCHOSOM RES, V60, P631, DOI 10.1016/j.jpsychores.2005.10.020
   Broadbent E, 2015, PSYCHOL HEALTH, V30, P1361, DOI 10.1080/08870446.2015.1070851
   Capone V, 2013, J COMMUNITY APPL SOC, V23, P98, DOI 10.1002/casp.2103
   Costantini M, 1999, SUPPORT CARE CANCER, V7, P121, DOI 10.1007/s005200050241
   Dunkel A, 2011, J BEHAV MED, V34, P351, DOI 10.1007/s10865-011-9324-x
   Figueiras MJ, 2015, PSYCHOL HEALTH MED, V20, P570, DOI 10.1080/13548506.2014.993662
   Fishta A, 2015, INT ARCH OCC ENV HEA, V88, P997, DOI 10.1007/s00420-015-1019-0
   Foxwell R, 2013, J PSYCHOSOM RES, V75, P211, DOI 10.1016/j.jpsychores.2013.05.003
   Fraire M., 2008, International Journal Of Psychology Psychological Therapy, V8, P237
   Grace SL, 2005, J PSYCHOSOM RES, V59, P153, DOI 10.1016/j.jpsychores.2005.05.005
   Groben S, 2011, J PSYCHOSOM RES, V70, P229, DOI 10.1016/j.jpsychores.2010.09.002
   Gump BB, 2001, J AM GERIATR SOC, V49, P284, DOI 10.1046/j.1532-5415.2001.4930284.x
   Hopewell L, 2009, REV POLICY RES, V26, P589, DOI 10.1111/j.1541-1338.2009.00407.x
   Hoth KF, 2011, J PSYCHOSOM RES, V70, P465, DOI 10.1016/j.jpsychores.2010.10.005
   Johnston M, 2000, J PSYCHOSOM RES, V48, P579, DOI 10.1016/S0022-3999(00)00102-1
   Juergens MC, 2010, J PSYCHOSOM RES, V68, P553, DOI 10.1016/j.jpsychores.2009.10.004
   Knoop H, 2012, PSYCHOL MED, V42, P205, DOI 10.1017/S0033291711000924
   Mazzoni D, 2014, J HEALTH PSYCHOL, V19, P689, DOI 10.1177/1359105313477674
   Mendis S., 2011, GLOBAL ATLAS CARDIOV, P1
   Moss-Morris R, 2002, PSYCHOL HEALTH, V17, P1, DOI 10.1080/08870440290001494
   Nogueira M, 2012, ARQ NEURO-PSIQUIAT, V70, P125, DOI 10.1590/S0004-282X2012000200010
   Papaleo B, 2013, J WORKPLACE LEARN, V25, P247, DOI 10.1108/13665621311316438
   Petrie KJ, 2002, PSYCHOSOM MED, V64, P580, DOI 10.1097/00006842-200207000-00007
   Petrie KJ, 1996, BRIT MED J, V312, P1191
   Price A, 2012, J PAIN SYMPTOM MANAG, V43, P819, DOI 10.1016/j.jpainsymman.2011.05.013
   Reges O, 2011, PATIENT EDUC COUNS, V85, pE155, DOI 10.1016/j.pec.2010.12.022
   Roesch SC, 2001, J PSYCHOSOM RES, V50, P205, DOI 10.1016/S0022-3999(01)00188-X
   Savaresi S. M., 2001, P 2001 SIAM INT C DA, DOI [10.1137/1.9781611972719.5, DOI 10.1137/1.9781611972719.5]
   Wang C, 2010, CANCER CAUSE CONTROL, V21, P99, DOI 10.1007/s10552-009-9439-3
   Weinman J, 1996, PSYCHOL HEALTH, V11, P431, DOI 10.1080/08870449608400270
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 41
TC 1
Z9 3
U1 1
U2 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0887-0446
EI 1476-8321
J9 PSYCHOL HEALTH
JI Psychol. Health
PY 2018
VL 33
IS 4
BP 537
EP 554
DI 10.1080/08870446.2017.1380810
PG 18
WC Public, Environmental & Occupational Health; Psychology,
   Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Psychology
GA FZ4KC
UT WOS:000427560100006
PM 28984484
DA 2025-06-11
ER

PT J
AU Rana, S
   Ali, S
   Wani, HA
   Mushtaq, QD
   Sharma, S
   Rehman, MU
AF Rana, Sanjeev
   Ali, Shafat
   Wani, Hilal Ahmad
   Mushtaq, Qazi Danish
   Sharma, Swarkar
   Rehman, Muneeb U.
TI Metabolic syndrome and underlying genetic determinants-A systematic
   review
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Review
DE Metabolic syndrome; Gene polymorphism; Twin; Family; Predisposition;
   Phenotype; Determinants; Linkage
ID C-REACTIVE PROTEIN; INSULIN-RESISTANCE SYNDROME; CORONARY-HEART-DISEASE;
   ACID-BINDING PROTEIN-2; PPAR-GAMMA GENE; INSERTION/DELETION
   POLYMORPHISM; CARDIOVASCULAR-DISEASE; PROVISIONAL REPORT; HISPANIC
   FAMILIES; OXIDATIVE STRESS
AB The metabolic syndrome is a cluster of heritable and related traits which has been associated with a range of pathophysiological factors including dyslipidaemia, abdominal obesity, increased fasting plasma glucose (FPG) and hypertension. The documented genetic basis of the metabolic syndrome include several chromosomal positions, numerous candidate gene-associated polymorphisms, different genetic variants, which are linked to the syndrome either as a trait or entities mainly linked to metabolic process. Additionally, the latest findings related to the contribution of epigenetic mechanisms, microRNAs, sporadic variants, non-coding RNAs, and assessing the role of genes in molecular systems has enhanced our understanding of the syndrome. Considerable work has been done to understand the underlying disease mechanisms by elucidating its genetic etiology. Nonetheless, a common shared genetic cause has not been established to clarify the coexistence of their components and further investigation is required. While mostly neglected and rarely known, hereditary predisposition needs to be studied, including with the current defective phenotypic condition descriptions. Metabolic syndrome is a multi-faceted characteristic with abundant properties and the condition can arise from interactions between environmental variables such as physical inactivity, caloric obesity and genetic susceptibility. Although there is support for genetic determinants from family and twin research, there is still no recognised genomic DNA marker for genetic association and linkages with quite a long way off potential for clinical application. In the present review efforts have been made to through light on the various genetic determinants with large effects that underlie with the association of these traits to this syndrome. The heterogeneity and multifactorial heritability of MetS, however, has been a challenge towards understanding the factors underlying the association of these traits.
C1 [Rana, Sanjeev] Shri Mata Vaishno Devi Univ SMVDU, Human Genom Res Grp, Katra, Jammu & Kashmir, India.
   [Ali, Shafat] Univ Kashmir, Res Dev Ctr, Cytogenet & Mol Biol Lab, Srinagar, India.
   [Wani, Hilal Ahmad] Govt Degree Coll Sumbal, Dept Biochem, Bandipora, Jammu & Kashmir, India.
   [Mushtaq, Qazi Danish] Sri Pratap Coll, Dept Biochem, Srinagar, Jammu & Kashmir, India.
   [Sharma, Swarkar] Shri Mata Vaishno Devi Univ SMVDU, Sch Biotechnol, Human Genom Res Grp, Katra, Jammu & Kashmir, India.
   [Rehman, Muneeb U.] King Saud Univ, Coll Clin Pharm, Riyadh, Saudi Arabia.
C3 Shri Mata Vaishno Devi University; University of Kashmir; Shri Mata
   Vaishno Devi University; King Saud University
RP Wani, HA (corresponding author), Govt Degree Coll Sumbal, Dept Biochem, Bandipora, Jammu & Kashmir, India.; Rehman, MU (corresponding author), King Saud Univ, Coll Clin Pharm, Riyadh, Saudi Arabia.
EM hilalbiochem2007@gmail.com; muneebbjh@gmail.com
RI ALI, SHAFAT/AAG-6507-2021; sharma, swarkar/B-8096-2008
OI Rana, Sanjeev/0000-0001-7607-6931; Ali, Shafat/0000-0001-8403-423X;
   sharma, swarkar/0000-0001-8857-5906
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Ambye L, 2005, DIABETES RES CLIN PR, V67, P175, DOI 10.1016/j.diabres.2004.06.013
   Andersen G, 2006, DIABETOLOGIA, V49, P75, DOI 10.1007/s00125-005-0049-7
   Aronson D, 2004, J AM COLL CARDIOL, V44, P2003, DOI 10.1016/j.jacc.2004.08.030
   Aronson D, 2004, INT J OBESITY, V28, P674, DOI 10.1038/sj.ijo.0802609
   Arya R, 2002, DIABETES, V51, P841, DOI 10.2337/diabetes.51.3.841
   Austin MA, 2004, DIABETES, V53, P1166, DOI 10.2337/diabetes.53.4.1166
   Balkau B, 1999, DIABETIC MED, V16, P442
   Barroso I, 2019, CELL, V177, P146, DOI 10.1016/j.cell.2019.02.024
   Berenjy S., 2010, J HEALTH SCI, V2, P117
   Bing C, 2005, DIABETIC MED, V22, P1157, DOI 10.1111/j.1464-5491.2005.01575.x
   Cahill LE, 2013, CIRCULATION, V128, P337, DOI 10.1161/CIRCULATIONAHA.113.001474
   Cao H, 2000, HUM MOL GENET, V9, P109, DOI 10.1093/hmg/9.1.109
   CARMELLI D, 1994, AM J HUM GENET, V55, P566
   Chen W, 1999, ATHEROSCLEROSIS, V145, P197, DOI 10.1016/S0021-9150(99)00025-8
   Chow LS, 2020, OBESITY, V28, P860, DOI [10.1002/oby.22756, 10.1002/oby.22785]
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Costa LA, 2002, DIABETES CARE, V25, P2365, DOI 10.2337/diacare.25.12.2365
   Dallongeville J, 2003, J CLIN ENDOCR METAB, V88, P4862, DOI 10.1210/jc.2003-030173
   do Nascimento FV, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/s13098-015-0036-1
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Edwards KL, 1997, GENET EPIDEMIOL, V14, P241, DOI 10.1002/(SICI)1098-2272(1997)14:3<241::AID-GEPI3>3.0.CO;2-8
   Efeyan A, 2015, NATURE, V517, P302, DOI 10.1038/nature14190
   Einhorn Daniel, 2003, Endocr Pract, V9, P237
   Erkkilä AT, 2002, NUTR METAB CARDIOVAS, V12, P53
   Falkner B, 2014, CURR HYPERTENS REP, V16, DOI 10.1007/s11906-014-0449-5
   Fallaize R, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-05802-2
   Feinman RD, 2015, NUTRITION, V31, P1, DOI 10.1016/j.nut.2014.06.011
   Fernandez ML, 2004, THROMB HAEMOSTASIS, V92, P413, DOI 10.1160/TH04-02-0103
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   Frederiksen L, 2003, DIABETOLOGIA, V46, P729, DOI 10.1007/s00125-003-1092-x
   Frederiksen L, 2002, J CLIN ENDOCR METAB, V87, P3989, DOI 10.1210/jc.87.8.3989
   Garaulet M, 2020, TRENDS ENDOCRIN MET, V31, P192, DOI 10.1016/j.tem.2019.11.011
   Gill S, 2015, CELL METAB, V22, P789, DOI 10.1016/j.cmet.2015.09.005
   Gisondi P, 2018, CLIN DERMATOL, V36, P21, DOI 10.1016/j.clindermatol.2017.09.005
   Grandl G, 2018, SEMIN IMMUNOPATHOL, V40, P215, DOI 10.1007/s00281-017-0666-5
   Greenland P, 2005, ARCH INTERN MED, V165, P2454, DOI 10.1001/archinte.165.21.2454
   Guettier JM, 2005, J CLIN ENDOCR METAB, V90, P1705, DOI 10.1210/jc.2004-1338
   Gupta NJ, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0172852
   Ha K, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102437
   Habtezion A, 2015, CURR OPIN GASTROEN, V31, P395, DOI 10.1097/MOG.0000000000000195
   Hamid YH, 2005, DIABETOLOGIA, V48, P445, DOI 10.1007/s00125-004-1659-1
   Hamid YH, 2005, DIABETOLOGIA, V48, P251, DOI 10.1007/s00125-004-1623-0
   Han TS, 2002, DIABETES CARE, V25, P2016, DOI 10.2337/diacare.25.11.2016
   Hegele RA, 2005, AM J PHYSIOL-REG I, V289, pR663, DOI 10.1152/ajpregu.00275.2005
   Hegele RA, 2000, PHYSIOL GENOMICS, V3, P39, DOI 10.1152/physiolgenomics.2000.3.1.39
   Hegele RA, 2002, ARTERIOSCL THROM VAS, V22, P1058, DOI 10.1161/01.ATV.0000026801.56080.14
   Hegele RA, 2001, J CLIN ENDOCR METAB, V86, P2747, DOI 10.1210/jc.86.6.2747
   Hegele RA, 2001, CIRCULATION, V103, P2225
   Heymsfield SB, 2007, AM J CLIN NUTR, V85, P346, DOI 10.1093/ajcn/85.2.346
   Hosoki K, 2008, EUR J HUM GENET, V16, P1019, DOI 10.1038/ejhg.2008.90
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Jang MJ, 2009, ARTERIOSCL THROM VAS, V29, P311, DOI 10.1161/ATVBAHA.109.184085
   JEUNEMAITRE X, 1992, CELL, V71, P169, DOI 10.1016/0092-8674(92)90275-H
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   Kant AK, 2015, J ACAD NUTR DIET, V115, P50, DOI 10.1016/j.jand.2014.06.354
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Kissebah AH, 2000, P NATL ACAD SCI USA, V97, P14478, DOI 10.1073/pnas.97.26.14478
   Kondo H, 2002, DIABETES, V51, P2325, DOI 10.2337/diabetes.51.7.2325
   Kotzka J, 2004, EXPERT OPIN THER TAR, V8, P141, DOI 10.1517/eott.8.2.141.30248
   Krishnamoorthy Y, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0240971
   Lahiry P, 2008, J NUTRIGENET NUTRIGE, V1, P118, DOI 10.1159/000112459
   Langefeld CD, 2004, DIABETES, V53, P1170, DOI 10.2337/diabetes.53.4.1170
   Lawlor DA, 2005, J CLIN ENDOCR METAB, V90, P5677, DOI 10.1210/jc.2005-0825
   Lee KE, 2003, BMC GENET, V4, DOI 10.1186/1471-2156-4-S1-S94
   Lee YJ, 2002, DIABETES CARE, V25, P1002, DOI 10.2337/diacare.25.6.1002
   Lin HF, 2005, DIABETOLOGIA, V48, P2006, DOI 10.1007/s00125-005-1892-2
   Loos RJF, 2003, J CLIN ENDOCR METAB, V88, P5935, DOI 10.1210/jc.2003-030553
   Malik S, 2005, DIABETES CARE, V28, P690, DOI 10.2337/diacare.28.3.690
   Maury E, 2010, CIRC RES, V106, P447, DOI 10.1161/CIRCRESAHA.109.208355
   McCarthy JJ, 2003, HUM GENET, V114, P87, DOI 10.1007/s00439-003-1026-1
   Meirhaeghe A, 2005, MOL GENET METAB, V86, P293, DOI 10.1016/j.ymgme.2005.05.006
   Meirhaeghe A, 2005, DIABETES, V54, P3043, DOI 10.2337/diabetes.54.10.3043
   Milagro FI, 2012, CHRONOBIOL INT, V29, P1180, DOI 10.3109/07420528.2012.719967
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Ohashi K, 2004, J AM COLL CARDIOL, V43, P1195, DOI 10.1016/j.jacc.2003.10.049
   Okunrintemi V, 2020, CIRCULATION, V142
   Park HK, 2017, KOREAN J INTERN MED, V32, P239, DOI 10.3904/kjim.2016.229
   Pérez-Martínez P, 2017, NUTR REV, V75, P307, DOI 10.1093/nutrit/nux014
   Pollex RL, 2006, ATHEROSCLEROSIS, V184, P121, DOI 10.1016/j.atherosclerosis.2005.03.024
   Pollex RL, 2005, ARTERIOSCL THROM VAS, V25, P1541, DOI 10.1161/01.ATV.0000173307.25652.89
   Pot GK, 2016, P NUTR SOC, V75, P475, DOI 10.1017/S0029665116000239
   Povel CM, 2011, OBES REV, V12, P952, DOI 10.1111/j.1467-789X.2011.00907.x
   Qian JY, 2019, INT J OBESITY, V43, P1644, DOI 10.1038/s41366-018-0208-9
   Rains JL, 2011, FREE RADICAL BIO MED, V50, P567, DOI 10.1016/j.freeradbiomed.2010.12.006
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Rhee EJ, 2006, ARCH MED RES, V37, P86, DOI 10.1016/j.arcmed.2005.04.008
   Ridderstråle M, 2002, DIABETES, V51, P3554, DOI 10.2337/diabetes.51.12.3554
   Riou J, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0119161
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Robitaille J, 2004, J HUM GENET, V49, P482, DOI 10.1007/s10038-004-0177-9
   Rodriguez-Nunez I, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-00484-2
   Rosmond R, 2002, OBES RES, V10, P1078, DOI 10.1038/oby.2002.146
   Rutter MK, 2004, CIRCULATION, V110, P380, DOI 10.1161/01.CIR.0000136581.59584.0E
   Samson SL, 2014, ENDOCRIN METAB CLIN, V43, P1, DOI 10.1016/j.ecl.2013.09.009
   Sattar N, 2003, CIRCULATION, V108, P414, DOI 10.1161/01.CIR.0000080897.52664.94
   Scuteri A, 2015, EUR J PREV CARDIOL, V22, P486, DOI 10.1177/2047487314525529
   Shen ZM, 2021, BMC GASTROENTEROL, V21, DOI 10.1186/s12876-020-01579-3
   Siffert W, 1999, J AM SOC NEPHROL, V10, P1921
   Siffert W, 1998, NAT GENET, V18, P45, DOI 10.1038/ng0198-45
   SING CF, 1985, AM J HUM GENET, V37, P268
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Song QB, 2015, DIABETES VASC DIS RE, V12, P189, DOI 10.1177/1479164114562410
   Sookoian S, 2011, CURR HYPERTENS REP, V13, P149, DOI 10.1007/s11906-010-0164-9
   Sperling LS, 2015, J AM COLL CARDIOL, V66, P1050, DOI 10.1016/j.jacc.2015.06.1328
   Stancáková A, 2014, REV ENDOCR METAB DIS, V15, P243, DOI 10.1007/s11154-014-9293-9
   Steinle NI, 2004, ARTERIOSCL THROM VAS, V24, P1708, DOI 10.1161/01.ATV.0000136384.53705.c9
   Steppan CM, 2001, NATURE, V409, P307, DOI 10.1038/35053000
   Stern MP, 2004, DIABETES CARE, V27, P2676, DOI 10.2337/diacare.27.11.2676
   Suliga E, 2018, MED SCI MONITOR, V24, P7633, DOI 10.12659/MSM.907582
   Suliga E, 2017, NUTRIENTS, V9, DOI 10.3390/nu9121366
   Sutton BS, 2005, HUM GENET, V117, P107, DOI 10.1007/s00439-005-1260-9
   Swiatkiewicz I, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21030807
   Swiatkiewicz I, 2018, KARDIOL POL, V76, P821, DOI 10.5603/KP.a2018.0091
   Sygnowska E, 2012, KARDIOL POL, V70, P718
   Szewczyk-Golec K, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/8494107
   Szewczyk-Golec K, 2015, J PINEAL RES, V59, P277, DOI 10.1111/jpi.12257
   Vera B, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-017-18268-z
   Wang HN, 2012, MOL BIOL REP, V39, P5691, DOI 10.1007/s11033-011-1377-y
   Waterworth DM, 2000, ARTERIOSCL THROM VAS, V20, P2663, DOI 10.1161/01.ATV.20.12.2663
   Wu KD, 2002, HYPERTENS RES, V25, P529
   Yankey, 2017, THESIS GEORGIA STAT
   Zarrinpar A, 2016, TRENDS ENDOCRIN MET, V27, P69, DOI 10.1016/j.tem.2015.11.007
   Zhang Y, 2013, BMC MED GENOMICS, V6, DOI 10.1186/1755-8794-6-9
   Zhou JM, 2016, BIOMED ENVIRON SCI, V29, P505, DOI 10.3967/bes2016.066
   Ziki MDA, 2016, CURR OPIN LIPIDOL, V27, P162, DOI 10.1097/MOL.0000000000000276
NR 129
TC 17
Z9 19
U1 1
U2 9
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD JUN
PY 2022
VL 21
IS 1
BP 1095
EP 1104
DI 10.1007/s40200-022-01009-z
EA MAR 2022
PG 10
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA 1V2OI
UT WOS:000763824600002
PM 35673448
OA Green Published
DA 2025-06-11
ER

PT J
AU Skogberg, N
   Castaneda, AE
   Agyemang, C
   Koponen, P
   Lilja, E
   Laatikainen, T
AF Skogberg, Natalia
   Castaneda, Anu E.
   Agyemang, Charles
   Koponen, Paivikki
   Lilja, Eero
   Laatikainen, Tiina
TI The association of depressive and anxiety symptoms with the metabolic
   syndrome and its components among Russian, Somali, and Kurdish origin
   adults in Finland: A population-based study
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Metabolic syndrome; Depressive symptoms; Anxiety symptoms; Migrant
ID RISK; METAANALYSIS; MIGRANTS; DISEASE; SWEDEN
AB Objective: Positive association of depressive and anxiety symptoms with the metabolic syndrome (MetS) have been reported, however there is little information on these among migrant origin populations. The aim of this study was to examine these associations among diverse migrant origin populations in Finland. Methods: Data of 318 Russian, 212 Somali, and 321 Kurdish origin participants in the cross-sectional Finnish Migrant Health and Wellbeing Study (Maamu) aged 30-64 years was used. The general population reference group constituted of 786 Health 2011 Survey participants. Depressive and anxiety symptoms were measured with HSCL-25 subscales. Harmonized definition of MetS was used. Results: Depressive symptoms were associated with elevated blood pressure in Kurdish origin (30.1%, 95% CI 22.7-38.8 vs. 19.9%, 95%CI 15.4-25.4 for those with and without symptoms respectively); and elevated waist circumference (72.1%, 95%CI 56.9-83.5 vs. 55.0%, 95%CI 50.6-59.4) and triglycerides (30.8%, 95%CI 16.0-51.0 vs. 11.9%, 95%CI 9.3-15.0) in general population. Anxiety symptoms were associated with MetS (47.0%, 95%CI 37.6-56.7 vs. 31.9%, 95%CI 26.7-37.6) and elevated blood pressure (37.2%, 95%CI 28.3-46.9 vs. 18.8%, 95%CI 14.7-23.6), and with elevated triglycerides in Somali origin (33.0%, 95%CI 14.5-59.0 vs. 5.7%, 95%CI 3.3-9.6) and general population (30.2%, 95%CI 16.4-48.8, 12.8%, 95%CI 9.9-16.2). No associations between low HDL-cholesterol and depressive or anxiety symptoms were observed. Conclusion: Cardiometabolic health should be taken into account in mental health services. Future studies should explore the underlying pathways to the observed differences in strengths of associations of depressive and anxiety symptoms with MetS and its components across diverse migrant origin populations.
C1 [Skogberg, Natalia; Castaneda, Anu E.; Koponen, Paivikki; Lilja, Eero; Laatikainen, Tiina] Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland.
   [Agyemang, Charles] Univ Amsterdam, Amsterdam Univ Med Ctr, Dept Publ & Occupat Hlth, Amsterdam, Netherlands.
   [Laatikainen, Tiina] Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
   [Laatikainen, Tiina] Joint Municipal Author Social & Hlth Serv Siun Sot, Joensuu, Finland.
   [Skogberg, Natalia] Finnish Inst Hlth & Welf, Mannerheimintie 166,POB 27, Helsinki 00271, Finland.
C3 University of Amsterdam
RP Skogberg, N (corresponding author), Finnish Inst Hlth & Welf, Mannerheimintie 166,POB 27, Helsinki 00271, Finland.
EM natalia.skogberg@thl.fi
RI Laatikainen, Tiina/ABD-6622-2021
OI Skogberg, Natalia/0000-0002-8829-4159
FU Ane and Signe Gyllenberg foundation [5165]; Finnish Cultural Foundation
   (AEC)
FX The authors would like to acknowledge all of the participants in the
   Migrant Health and Wellbeing Study and the Health2011 Survey. This work
   was supported by the Ane and Signe Gyllenberg foundation (NS, grant
   number 5165) and by the Finnish Cultural Foundation (AEC) . The funding
   bodies had no role in study design; in the collection, analysis and
   interpretation of data; in the writing of the report; or in the decision
   to submit the article for publication. The authors would like to thank
   Tyler Prinkey for the help with formatting references and conducting a
   preliminary literature search.
CR Agyemang C, 2013, EUR J PUBLIC HEALTH, V23, P447, DOI 10.1093/eurpub/cks041
   Agyemang C, 2010, INT J CARDIOL, V141, P266, DOI 10.1016/j.ijcard.2008.12.023
   Aichberger MC, 2010, EUR PSYCHIAT, V25, P468, DOI 10.1016/j.eurpsy.2009.11.009
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Bean T, 2007, ADOLESCENCE, V42, P51
   Bennet L, 2014, J HYPERTENS, V32, P2362, DOI 10.1097/HJH.0000000000000345
   Blackmore R, 2020, PLOS MED, V17, DOI 10.1371/journal.pmed.1003337
   Butnoriene J, 2014, PSYCHONEUROENDOCRINO, V40, P269, DOI 10.1016/j.psyneuen.2013.11.002
   Castaneda A.E, 2019, Finnish Yearbook of Population Research, V53, P89, DOI DOI 10.23979/FYPR.74048
   Daryani A, 2007, NUTR METAB CARDIOVAS, V17, P748, DOI 10.1016/j.numecd.2006.07.011
   DEROGATIS LR, 1974, BEHAV SCI, V19, P1, DOI 10.1002/bs.3830190102
   Deschênes SS, 2020, PSYCHOSOM MED, V82, P296, DOI 10.1097/PSY.0000000000000790
   Dortland AKBV, 2010, J CLIN PSYCHIAT, V71, P729, DOI 10.4088/JCP.08m04865blu
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   Gibson-Smith D, 2018, SOC PSYCH PSYCH EPID, V53, P629, DOI 10.1007/s00127-018-1512-3
   Graubard BI, 1999, BIOMETRICS, V55, P652, DOI 10.1111/j.0006-341X.1999.00652.x
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Hjellset VT, 2011, J IMMIGR MINOR HEALT, V13, P732, DOI 10.1007/s10903-010-9409-6
   Honkalampi K, 2021, J PSYCHOSOM RES, V143, DOI 10.1016/j.jpsychores.2021.110389
   Kahl KG, 2015, BRAIN BEHAV, V5, DOI 10.1002/brb3.306
   Kaiser T, 2021, DEPRESS ANXIETY, V38, P307, DOI 10.1002/da.23136
   Kuczmierczyk AR, 1996, CAN J PSYCHIAT, V41, P465, DOI 10.1177/070674379604100712
   Lehtonen R., 2004, Practical Methods for Design and Analysis of Complex Surveys
   Lindert J, 2009, SOC SCI MED, V69, P246, DOI 10.1016/j.socscimed.2009.04.032
   Lundqvist A., 2016, Health 2011 survey methods
   Luppino FS, 2011, PSYCHOSOM MED, V73, P257, DOI 10.1097/PSY.0b013e31820a59c0
   Mattei G, 2015, J PSYCHOSOM RES, V78, P614, DOI 10.1016/j.jpsychores.2015.03.094
   Moradi Yousef, 2021, Clin Diabetes Endocrinol, V7, P4, DOI 10.1186/s40842-021-00117-8
   Morbach C, 2019, INT J CARDIOL, V286, P186, DOI 10.1016/j.ijcard.2018.10.098
   NETTELBLADT P, 1993, SOC PSYCH PSYCH EPID, V28, P130, DOI 10.1007/BF00801743
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pan Y, 2015, NEUROPSYCH DIS TREAT, V11, P1121, DOI 10.2147/NDT.S77710
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Rask S, 2015, BMC PUBLIC HEALTH, V15, DOI 10.1186/s12889-015-1629-1
   Rethorst CD, 2014, J CLIN PSYCHIAT, V75, pE1428, DOI 10.4088/JCP.14m09009
   Skogberg N, 2017, INT J CARDIOL, V232, P63, DOI 10.1016/j.ijcard.2017.01.051
   Skogberg N, 2019, CARDIOVASCULAR RISK, P2342
   Tinghög P, 2010, COMMUNITY MENT HLT J, V46, P65, DOI 10.1007/s10597-009-9227-2
   Tolonen H, 2016, EHES manual. Part B. Fieldwork procedures
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
   van Leijden MJ, 2018, SOC PSYCH PSYCH EPID, V53, P921, DOI 10.1007/s00127-018-1533-y
   Zhang WH, 2021, ETHNIC DIS, V31, P243, DOI 10.18865/ed.31.2.243
NR 42
TC 8
Z9 8
U1 4
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD AUG
PY 2022
VL 159
AR 110944
DI 10.1016/j.jpsychores.2022.110944
EA MAY 2022
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 2G2IL
UT WOS:000813420900007
PM 35605441
OA hybrid
DA 2025-06-11
ER

PT J
AU Stegerhoek, P
   Kooijman, K
   Ziesemer, K
   IJzerman, H
   Kuijer, PPFM
   Verhagen, E
AF Stegerhoek, Pablo
   Kooijman, Karlijn
   Ziesemer, Kirsten
   IJzerman, Herman
   Kuijer, P. Paul F. M.
   Verhagen, Evert
TI Risk factors for adverse health in military and law enforcement
   personnel; an umbrella review
SO BMC PUBLIC HEALTH
LA English
DT Review
DE Health; Risk Factor; Military Personnel; Law Enforcement;
   Musculoskeletal Injury; Mental Health; Chronic Disease
ID POLICE OFFICERS; MUSCULOSKELETAL INJURIES; GENETIC RISK; PREVALENCE;
   OBESITY; STRESS; RESPONDERS; DEPRESSION; BARRIERS; BURNOUT
AB Background A better understanding of adverse health and underlying risk factors in the context of military and law enforcement is essential to developing future preventative strategies. We conducted an umbrella review to provide an overview of the current literature regarding risk factors for adverse health in military and law enforcement populations.
   Methods We systematically searched the literature for systematic reviews and meta-analyses regarding risk factors for adverse health in military or law enforcement populations. We critically appraised the studies that matched our inclusion criteria, extracted the adverse health outcomes and underlying risk factors, and narratively synthesised the findings.
   Results This umbrella review included 34 systematic reviews that covered data from 43 countries. We identified twenty-six adverse health outcomes and 220 underlying risk factors. The adverse health outcomes covered in the included systematic reviews were one infectious disease (Heliobacter pylori infection); two endocrine, nutritional, or metabolic diseases (metabolic syndrome and obesity); seven mental, behavioural, or neurodevelopmental disorders (adjustment disorder, alcohol misuse, anxiety, depression, poor mental health, PTSD, and stress); two diseases of the nervous system (insomnia and sleep-disordered breathing); one disease of the ear or mastoid process (noise-induced hearing loss); eight diseases of the musculoskeletal system and connective tissue (cervical spine injuries, injuries, lower extremity injuries, musculoskeletal injuries, neck pain, rhabdomyolysis, and stress fractures); one symptom, signs and abnormal clinical and laboratory findings, not elsewhere classified (suicidal ideation); three injuries, poisonings, or other consequences of external causes (concussion, heat illness, and suicide); and one factor influencing health status and contact with health services (burnout). Of the 220 identified risk factors, 136 were modifiable, and the most frequently reported were female sex, older age, lower functional movement screen scores, maladaptive coping, lack of social support, and neuroticism.
   Conclusion This umbrella review identified twenty-six adverse health outcomes and their underlying risk factors in military and law enforcement populations. Hereby, this study provides potential starting points for preventing adverse health in these populations. It also identifies a broad lack of systematic reviews investigating mental, behavioural, or neurodevelopmental disorders in military populations and diseases of the musculoskeletal system and connective tissue in law enforcement populations.
   Prospero Registration NumberCRD42022378123.
C1 [Stegerhoek, Pablo; Kooijman, Karlijn; Kuijer, P. Paul F. M.; Verhagen, Evert] Amsterdam UMC, Amsterdam Collaborat Hlth & Safety Sports, Dept Publ & Occupat Hlth, Amsterdam Movement Sci, Amsterdam, Netherlands.
   [Stegerhoek, Pablo; Kuijer, P. Paul F. M.] Univ Amsterdam, Amsterdam UMC, Amsterdam Publ Hlth Res Inst, Dept Publ & Occupat Hlth, Amsterdam, Netherlands.
   [Stegerhoek, Pablo] Acad Med Ctr, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
   [Stegerhoek, Pablo; IJzerman, Herman] Royal Netherlands Marechaussee, Hlth Care Sect, Pl Kalvermarkt Complex, Kalvermarkt 32, NL-2511 CB The Hague, Netherlands.
   [Kooijman, Karlijn] Netherlands Inst Study Crime & Law Enforcement, Nederlands Studiecentrum Criminaliteit Rechtshand, Amsterdam, Netherlands.
   [Kooijman, Karlijn] Vrije Univ Amsterdam, Fac Behav & Movement Sci, Dept Human Movement Sci, Amsterdam Movement Sci, Amsterdam, Netherlands.
   [Ziesemer, Kirsten] Vrije Univ, Univ Lib, Med Lib, Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; University of Amsterdam; Vrije
   Universiteit Amsterdam; University of Amsterdam; Vrije Universiteit
   Amsterdam; Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam
RP Stegerhoek, P (corresponding author), Amsterdam UMC, Amsterdam Collaborat Hlth & Safety Sports, Dept Publ & Occupat Hlth, Amsterdam Movement Sci, Amsterdam, Netherlands.; Stegerhoek, P (corresponding author), Univ Amsterdam, Amsterdam UMC, Amsterdam Publ Hlth Res Inst, Dept Publ & Occupat Hlth, Amsterdam, Netherlands.; Stegerhoek, P (corresponding author), Acad Med Ctr, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.; Stegerhoek, P (corresponding author), Royal Netherlands Marechaussee, Hlth Care Sect, Pl Kalvermarkt Complex, Kalvermarkt 32, NL-2511 CB The Hague, Netherlands.
EM p.m.stegerhoek@amsterdamumc.nl
RI Verhagen, Evert/A-1502-2013
OI Stegerhoek, Pablo/0000-0001-7636-8395; Kooijman, K./0009-0008-5441-6454
FU Royal Netherlands Marechaussee
FX The Royal Netherlands Marechaussee provided funding for the study.
CR Agrawal M, 2020, INT J CRIM JUSTICE S, V15, P34, DOI 10.5281/zenodo.3819100
   Aguayo R, 2017, AN PSICOL-SPAIN, V33, P383
   Ajslev JZN, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19052731
   Al Rumaithi M, 2023, OCCUP MED-OXFORD, V73, P236, DOI 10.1093/occmed/kqad067
   Alele F, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2019-031825
   Alele FO, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17197037
   Allisey A, 2016, PERS REV, V45, P663, DOI 10.1108/PR-06-2014-0125
   ALTMAN DG, 1995, BRIT MED J, V311, P485, DOI 10.1136/bmj.311.7003.485
   Alves L, 2023, J AFFECT DISORDERS, V332, P283, DOI 10.1016/j.jad.2023.03.081
   [Anonymous], 1992, The ICD-10 classification of mental and behavioural disorders: Clinical descriptions and diagnostic guidelines
   Arble E, 2017, J POLICE CRIM PSYCHO, V32, P1, DOI 10.1007/s11896-016-9191-z
   Archer LE, 2021, NEW HORIZ ADULT EDUC, V33, P17, DOI 10.1002/nha3.20331
   Aromataris E, 2015, INT J EVID-BASED HEA, V13, P132, DOI 10.1097/XEB.0000000000000055
   Baygi F, 2020, BMC ENDOCR DISORD, V20, DOI 10.1186/s12902-020-0489-6
   Bijur PE, 1997, ARCH PEDIAT ADOL MED, V151, P456, DOI 10.1001/archpedi.1997.02170420026004
   Boot CRL, 2024, SCAND J WORK ENV HEA, V50, P395, DOI 10.5271/sjweh.4180
   Boyce R.W., 1992, Health Values, V16, P22
   Brennan CJ, 2024, BMJ OPEN, V14, DOI 10.1136/bmjopen-2023-071776
   Brooks SK, 2018, J MENT HEALTH, V27, P80, DOI 10.1080/09638237.2016.1276536
   Brown SP, 2005, J APPL PSYCHOL, V90, P792, DOI 10.1037/0021-9010.90.4.792
   Bryan TG, 2017, Effects of absenteeism on company productivity, efficiency, and profitability
   Bunn PD, 2021, INT ARCH OCC ENV HEA, V94, P1173, DOI 10.1007/s00420-021-01700-3
   Bunn PD, 2019, PHYS THER SPORT, V35, P146, DOI 10.1016/j.ptsp.2018.11.011
   Burgess J E, 2009, J R Army Med Corps, V155, P11
   Cameron KL, 2016, J ATHL TRAINING, V51, P952, DOI 10.4085/1062-6050-51.5.03
   Carter R, 2005, MED SCI SPORT EXER, V37, P1338, DOI 10.1249/01.mss.0000174895.19639.ed
   Coenen P, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2021-049651
   Collins M, 2009, MED SPORT SCI, V54, P136, DOI 10.1159/000235701
   Cook Gray, 2006, N Am J Sports Phys Ther, V1, P62
   Cranwell-Ward J, 2005, Organizational Stress, P63
   da Silva FC, 2014, INT J OCCUP MED ENV, V27, P891, DOI 10.2478/s13382-014-0318-0
   Dao D, 2015, AM J SPORT MED, V43, P2064, DOI 10.1177/0363546514555971
   De Marchis P, 2018, ANN AGR ENV MED, V25, P162, DOI 10.26444/aaem/79922
   Dijksma CI, 2020, MIL MED, V185, pE480, DOI 10.1093/milmed/usz328
   dos Santos Bunn P, 2018, Fisioterapia em Movimento, V31
   Durn MA., 2006, Revista de psicologa social, V21, P95, DOI [10.1174/021347406775322205, DOI 10.1174/021347406775322205]
   European Patients Academy on Therapeutic Interventions, 2024, Risk factors in health and disease
   Galanis P, 2021, WORK, V68, P1255, DOI 10.3233/WOR-213455
   Gibbs DA, 2011, MIL PSYCHOL, V23, P36, DOI 10.1080/08995605.2011.534409
   Goodley H, 2021, What does it mean to be a soldier?
   Goodman P.S., 1984, Absenteeism: New approaches to understanding, measuring, and managing employee absence, P276
   Greinacher A, 2019, EUR J PSYCHOTRAUMATO, V10, DOI 10.1080/20008198.2018.1562840
   Hair K BZ, 2021, The Automated Systematic Search Deduplicator (ASySD): a rapid, open-source, interoperable tool to remove duplicate citations in biomedical systematic reviews
   Hamstra-Wright KL, 2015, BRIT J SPORT MED, V49, P362, DOI 10.1136/bjsports-2014-093462
   Haugen PT, 2017, J PSYCHIATR RES, V94, P218, DOI 10.1016/j.jpsychires.2017.08.001
   Hauret KG, 2010, AM J PREV MED, V38, pS61, DOI 10.1016/j.amepre.2009.10.021
   Hebebrand J, 2009, CHILD ADOL PSYCH CL, V18, P83, DOI 10.1016/j.chc.2008.07.006
   Nguyen H, 2016, J MANAGE, V42, P615, DOI 10.1177/0149206313490026
   Hoge CW, 2004, NEW ENGL J MED, V351, P13, DOI 10.1056/NEJMoa040603
   Hosseini Seyed Morteza, 2023, Iran J Psychiatry, V18, P213, DOI 10.18502/ijps.v18i2.12371
   Huang YJ, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0250779
   Jamieson N, 2023, J RELIG HEALTH, V62, P3904, DOI 10.1007/s10943-023-01885-6
   Karl JP, 2022, EUR J SPORT SCI, V22, P87, DOI 10.1080/17461391.2021.1930192
   Kendler KS, 2001, AM J PSYCHIAT, V158, P582, DOI 10.1176/appi.ajp.158.4.582
   Kollock R, 2019, IND HEALTH, V57, pE1
   Krishnan N, 2022, J POLICE CRIM PSYCHO, V37, P939, DOI 10.1007/s11896-022-09539-1
   Martinic MK, 2019, BMC MED RES METHODOL, V19, DOI 10.1186/s12874-019-0855-0
   Kyron MJ, 2021, J AFFECT DISORDERS, V281, P517, DOI 10.1016/j.jad.2020.12.021
   Lennox GM, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19010422
   Lentz L, 2019, AM J IND MED, V62, P3, DOI 10.1002/ajim.22929
   Lisman P, 2022, MIL MED, V187, P1318, DOI 10.1093/milmed/usac118
   Lonsway KA, 2013, POLICE Q, V16, P177, DOI 10.1177/1098611113475630
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Lyons K, 2021, BMC MUSCULOSKEL DIS, V22, DOI 10.1186/s12891-021-03986-3
   Magnavita N, 2018, INT ARCH OCC ENV HEA, V91, P377, DOI 10.1007/s00420-018-1290-y
   Marshall RE, 2017, PSYCHIAT RES, V253, P129, DOI 10.1016/j.psychres.2017.03.047
   Dantas GHM, 2023, REV ENVIRON HEALTH, V38, P613, DOI 10.1515/reveh-2022-0038
   McKenzie A., 2023, Adjustment disorder in the Armed Forces: a systematic review, V32, P962
   Miller L., 2004, J POLICE CRIM PSYCHO, V19, P30, DOI DOI 10.1007/BF02813871
   Moher D., 2009, ANN INTERN MED, V151, P264, DOI [10.7326/0003-4819-151-4-200908180-00135, DOI 10.7326/0003-4819-151-4-200908180-00135]
   Molloy JM, 2020, MIL MED, V185, pE1461, DOI 10.1093/milmed/usaa027
   Mona GG, 2019, J OCCUP MED TOXICOL, V14, DOI 10.1186/s12995-018-0221-x
   Moran RW, 2017, BRIT J SPORT MED, V51, P1661, DOI 10.1136/bjsports-2016-096938
   Mourad Ouzzani HH, 2016, Rayyan-a web and mobile app for systematic reviews
   Obayemi JE, 2020, ANN MED SURG, V50, P49, DOI 10.1016/j.amsu.2019.10.020
   Petereit-Haack G., 2020, Int J Environ Res Public Health, V17
   Peterson C, 2018, MMWR-MORBID MORTAL W, V67, P1253, DOI 10.15585/mmwr.mm6745a1
   Pierce Joseph R, 2017, J Sci Med Sport, V20 Suppl 4, pS79, DOI 10.1016/j.jsams.2017.08.021
   Pollarolo Marco, 2022, Iran J Otorhinolaryngol, V34, P211, DOI 10.22038/IJORL.2022.64036.3198
   R Development Core Team, 2022, R: A Language and Environment for Statistical Computing 2023
   Range J, 2023, J MIL VETERAN FAM HL, V9, P39, DOI 10.3138/jmvfh-2022-0061
   Reneker JC, 2019, MUSCULOSKEL SCI PRAC, V42, P173, DOI 10.1016/j.msksp.2019.04.004
   Rhon DI, 2022, EUR J SPORT SCI, V22, P16, DOI 10.1080/17461391.2021.1931464
   Robson K, 2024, HEALTHCARE-BASEL, V12, DOI 10.3390/healthcare12050595
   Rostami H, 2019, MIL MED, V184, pE415, DOI 10.1093/milmed/usz144
   Rough JA, 2017, WORLD MED HEALTH POL, V9, P206, DOI 10.1002/wmh3.228
   Roy TC, 2012, AVIAT SPACE ENVIR MD, V83, P1060, DOI 10.3357/ASEM.3341.2012
   Sammito S, 2021, MILITARY MED RES, V8, DOI 10.1186/s40779-021-00357-w
   Schram B, 2022, BMC WOMENS HEALTH, V22, DOI 10.1186/s12905-022-01899-4
   Schram B, 2022, BMC SPORTS SCI MED R, V14, DOI 10.1186/s13102-022-00443-z
   Scudamore EM, 2019, J STRENGTH COND RES, V33, P1848, DOI 10.1519/JSC.0000000000002829
   Selkirk GA, 2001, J APPL PHYSIOL, V91, P2055, DOI 10.1152/jappl.2001.91.5.2055
   Sherwood L, 2019, J TRAUMA STRESS, V32, P688, DOI 10.1002/jts.22431
   Shing EZ, 2016, J CLIN PSYCHOL, V72, P1287, DOI 10.1002/jclp.22327
   Sitoayu L., 2020, Journal of Health Education, V5, P39
   Sivakumar G, 2019, SPORTS HEALTH, V11, P425
   Smith L, 2016, SPORTS HEALTH, V8, P607, DOI 10.1177/1941738116670873
   Sorensen LN, 2022, J POLICE CRIM PSYCHO, V37, P752, DOI 10.1007/s11896-022-09547-1
   Stannard J, 2021, BMJ MILITARY HEALTH, V167, P255, DOI 10.1136/bmjmilitary-2020-001692
   Syed S, 2020, OCCUP ENVIRON MED, V77, P737, DOI 10.1136/oemed-2020-106498
   Thériault FL, 2020, MIL MED, V185, pE1255, DOI 10.1093/milmed/usaa015
   Thomas JL, 2010, ARCH GEN PSYCHIAT, V67, P614, DOI 10.1001/archgenpsychiatry.2010.54
   To D, 2021, CHIROPR MAN THER, V29, DOI 10.1186/s12998-021-00409-x
   van der Beek AJ, 2017, SCAND J WORK ENV HEA, V43, P526, DOI 10.5271/sjweh.3671
   van Oostrom SH, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006955.pub2
   Walree ES, 2022, DIABETES, V71, P2447, DOI 10.2337/db22-0478
   Wagner SL, 2020, AM J IND MED, V63, P600, DOI 10.1002/ajim.23120
   Wallace JB, 2021, OCCUP ENVIRON MED, V78, P900, DOI 10.1136/oemed-2020-107103
   Wang CM, 2022, INDIAN J PATHOL MICR, V65, P23, DOI 10.4103/IJPM.IJPM_1084_20
   Wearing SC, 2006, OBES REV, V7, P239, DOI 10.1111/j.1467-789X.2006.00251.x
   Whittaker JL, 2017, BRIT J SPORT MED, V51, P580, DOI 10.1136/bjsports-2016-096760
   Xue C, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0120270
   Zimmerman FH, 2012, CARDIOL REV, V20, P159, DOI 10.1097/CRD.0b013e318248d631
NR 113
TC 4
Z9 4
U1 4
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD NOV 13
PY 2024
VL 24
IS 1
AR 3151
DI 10.1186/s12889-024-20553-2
PG 20
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA U1U1Q
UT WOS:001409721200004
PM 39538210
OA gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Winning, A
   Glymour, MM
   McCormick, MC
   Gilsanz, P
   Kubzansky, LD
AF Winning, Ashley
   Glymour, M. Maria
   McCormick, Marie C.
   Gilsanz, Paola
   Kubzansky, Laura D.
TI Psychological Distress Across the Life Course and Cardiometabolic Risk
   Findings From the 1958 British Birth Cohort Study
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
DE biomarkers; cardiometabolic risk; epidemiology; life course; prospective
   study; psychological distress
ID C-REACTIVE PROTEIN; CARDIOVASCULAR HEALTH; CHILDHOOD; DEPRESSION;
   ADULTHOOD; STRESS; ASSOCIATIONS; DISPARITIES; DISORDERS; TEACHERS
AB BACKGROUND Research suggests cardiovascular and metabolic diseases are influenced by psychological distress in adulthood; however, this research is often limited to adult populations and/or a snapshot measure of distress. Given emerging recognition that cardiometabolic diseases have childhood origins, an important question is whether psychological distress earlier in life influences disease development.
   OBJECTIVES This study sought to assess whether life course patterns of psychological distress assessed from childhood through adulthood predict biomarkers of cardiometabolic risk in adulthood and whether effects of sustained distress differ from more limited exposure.
   METHODS The sample (n = 6,714) consists of members of the 1958 British Birth Cohort Study who completed repeated measures of psychological distress and a biomedical survey at age 45 years. Psychological distress profiles over the life course (no distress, childhood only, adulthood only, or persistent distress) were identified from 6 assessments between ages 7 and 42 years. Cardiometabolic risk was assessed by combining information on 9 biomarkers of immune, cardiovascular, and metabolic system function. Covariate adjusted linear regression models were used to assess associations between distress profiles and cardiometabolic risk.
   RESULTS Compared with those with no distress, cardiometabolic risk was higher among people with psychological distress in childhood only (beta = 0.11, SE = 0.03, p = 0.0002), in adulthood only (beta = 0.09, SE = 0.03, p = 0.007), and persistent across the life course (beta = 0.26, SE = 0.04, p < 0.0001).
   CONCLUSIONS Psychological distress at any point in the life course is associated with higher cardiometabolic risk. This is the first study to suggest that even if distress appears to remit by adulthood, heightened risk of cardiometabolic disease remains. Findings suggest early emotional development may be a target for primordial prevention and for promoting lifelong cardiovascular health. (C) 2015 by the American College of Cardiology Foundation.
C1 [Winning, Ashley; McCormick, Marie C.; Gilsanz, Paola; Kubzansky, Laura D.] Harvard Univ, TH Chan Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA 02115 USA.
   [Glymour, M. Maria] Univ Calif San Francisco, Sch Med, Dept Epidemiol & Biostat, San Francisco, CA USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health;
   University of California System; University of California San Francisco
RP Winning, A (corresponding author), Harvard Univ, TH Chan Sch Publ Hlth, Dept Social & Behav Sci, 677 Huntington Ave,Kresge 7th Floor, Boston, MA 02115 USA.
EM awinning@mail.harvard.edu
RI Glymour, Maria/AEM-8841-2022
OI Glymour, M. Maria/0000-0001-9644-3081
FU Julius B. Richmond Fellowship at the Harvard Center on the Developing
   Child; Martha May Eliot Fund at the Harvard T.H. Chan School of Public
   Health; Yerby Postdoctoral Fellowship; MRC [G1001799, MR/N01104X/1]
   Funding Source: UKRI
FX Dr. Winning was supported by the Julius B. Richmond Fellowship at the
   Harvard Center on the Developing Child, and by the Martha May Eliot Fund
   at the Harvard T.H. Chan School of Public Health. Dr. Gilsanz was
   supported by the Yerby Postdoctoral Fellowship. However, no direct
   funding was received or set aside for the writing of this paper. All
   other authors have reported that they have no relationships relevant to
   the contents of this paper to disclose.
CR Appleton AA, 2011, PSYCHOSOM MED, V73, P295, DOI 10.1097/PSY.0b013e31821534f6
   Atherton K, 2008, J EPIDEMIOL COMMUN H, V62, P216, DOI 10.1136/jech.2006.058966
   Chaiton MO, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-356
   Clark C, 2007, ARCH GEN PSYCHIAT, V64, P668, DOI 10.1001/archpsyc.64.6.668
   Cole TJ, 2012, PEDIATR OBES, V7, P284, DOI 10.1111/j.2047-6310.2012.00064.x
   Copeland WE, 2012, BIOL PSYCHIAT, V71, P15, DOI 10.1016/j.biopsych.2011.09.023
   Fuller E., 2006, TECHNICAL REPORT NAT
   GHODSIAN M, 1977, BRIT J SOC CLIN PSYC, V16, P23, DOI 10.1111/j.2044-8260.1977.tb00999.x
   Hazell P, 2007, CURR OPIN PSYCHIATR, V20, P315, DOI 10.1097/YCO.0b013e3281a7368d
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Jefferis BJMH, 2002, BRIT MED J, V325, P305, DOI 10.1136/bmj.325.7359.305
   Juster RP, 2010, NEUROSCI BIOBEHAV R, V35, P2, DOI 10.1016/j.neubiorev.2009.10.002
   King KE, 2011, PSYCHOSOM MED, V73, P572, DOI 10.1097/PSY.0b013e318227b062
   Kubzansky LD., 2013, A life course approach to mental disorders, P291
   Kuzawa CW, 2009, AM J HUM BIOL, V21, P2, DOI 10.1002/ajhb.20822
   Lloyd-Jones DM, 2010, CIRCULATION, V121, P586, DOI 10.1161/CIRCULATIONAHA.109.192703
   Marino M, 2014, AM J PREV MED, V47, P131, DOI 10.1016/j.amepre.2014.03.006
   Mausbach BT, 2012, HEALTH PSYCHOL, V31, P433, DOI 10.1037/a0027783
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   Miller GE, 2011, PSYCHOL BULL, V137, P959, DOI 10.1037/a0024768
   Nemeroff CB, 2004, J CLIN PSYCHIAT, V65, P18
   Parsons TJ, 2006, MED SCI SPORT EXER, V38, P547, DOI 10.1249/01.mss.0000188446.65651.67
   Pearson TA, 2003, CIRCULATION, V107, P499, DOI 10.1161/01.CIR.0000052939.59093.45
   Power C, 2006, INT J EPIDEMIOL, V35, P34, DOI 10.1093/ije/dyi183
   Power C, 2011, PSYCHONEUROENDOCRINO, V36, P87, DOI 10.1016/j.psyneuen.2010.06.010
   Pringle M, 1967, 11000 7 YEAR OLDS 1
   RUTTER M, 1967, J CHILD PSYCHOL PSYC, V8, P1, DOI 10.1111/j.1469-7610.1967.tb02175.x
   Rutter M., 1970, Education, health and behaviour
   Schafer JL, 1997, ANAL INCOMPLETE MULT
   Shepherd P., 2008, USER GUIDE BIOMEDICA
   Shin JK, 2012, DIABETES RES CLIN PR, V95, P406, DOI 10.1016/j.diabres.2011.10.043
   Southgate V., 1962, SOUTHGATE GROUP READ
   STANGER C, 1993, J CLIN CHILD PSYCHOL, V22, P107, DOI 10.1207/s15374424jccp2201_11
   Szmitko Paul E, 2006, J Cardiometab Syndr, V1, P66, DOI 10.1111/j.0197-3118.2006.05340.x
   Szmitko PE, 2006, J CARDIOMETAB SYNDR, V1, P70
   Thayer JF, 2005, PSYCHONEUROENDOCRINO, V30, P1050, DOI 10.1016/j.psyneuen.2005.04.014
   Tottenham N, 2010, FRONT HUM NEUROSCI, V3, DOI 10.3389/neuro.09.068.2009
NR 37
TC 72
Z9 83
U1 0
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD OCT 6
PY 2015
VL 66
IS 14
BP 1577
EP 1586
DI 10.1016/j.jacc.2015.08.021
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA CS3BI
UT WOS:000361945700009
PM 26429083
OA Bronze
DA 2025-06-11
ER

PT J
AU Gilstrap, LG
   Malhotra, R
   Peltier-Saxe, D
   Slicas, D
   Pineda, E
   Culhane-Hermann, C
   Cook, N
   Fernandez-Golarz, C
   Wood, M
AF Gilstrap, Lauren Gray
   Malhotra, Rajeev
   Peltier-Saxe, Donna
   Slicas, Donna
   Pineda, Eliana
   Culhane-Hermann, Catherine
   Cook, Nakela
   Fernandez-Golarz, Carina
   Wood, Malissa
TI Community-Based Primary Prevention Programs Decrease the Rate of
   Metabolic Syndrome Among Socioeconomically Disadvantaged Women
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; LIFE-STYLE; RISK; ASSOCIATION; PREVALENCE;
   HEALTH; TRENDS
AB Background: Metabolic Syndrome (MetSyn) is one of the strongest predictors of type 2 diabetes (DM2) and cardiovascular disease (CVD). It is associated with a 4- to 10-fold increased risk of DM2 and a 2- to 3-fold increased risk of CVD. Low income and minority women have some of the highest rates of MetSyn. This study examines the effect of a unique, community based, primary prevention program on the rates of MetSyn and health habits.
   Methods: Sixty-four low income and minority women were enrolled in the HAPPY (Health Awareness and Primary Prevention in Your neighborhood) Heart Program in an eastern suburb of Boston. Over these 2 years, patients were evaluated by an interdisciplinary medical team: their primary physician, cardiologist, nutritionist, physical therapist, and health coach. The rate of MetSyn was measured at baseline, year 1, and year 2. Comparisons were made either using the paired t test for normally distributed variables or the Wilcoxon Sign test for non-normal variables.
   Results: The rate of MetSyn fell from 64.7% at baseline to 34.9% at year 1 (p = 0.01) and 28.2% at year 2 (p < 0.001). This was driven by increases in high-density lipoprotein (HDL-C) (p < 0.001) and decreases in blood pressure (p = 0.05). Fasting blood glucose trended down, but the hemoglobin A1c (HbA1c) reached significance (decreasing from 6 to 5.8, p < 0.01). Nutrition and exercise habits trended toward improvement. There were significant decreases in anxiety (p < 0.001), depression (p = 0.006) and stress (p = 0.002).
   Conclusion: This lifestyle intervention program is effective at decreasing MetSyn in a socioeconomically disadvantaged, largely minority, female population. This program also decreases anxiety, stress, and depression among participants.
C1 [Gilstrap, Lauren Gray; Malhotra, Rajeev; Fernandez-Golarz, Carina] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA.
   [Malhotra, Rajeev; Wood, Malissa] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA.
   [Peltier-Saxe, Donna; Slicas, Donna; Pineda, Eliana; Culhane-Hermann, Catherine] Massachusetts Gen Hosp, Revere Hlth Ctr, Boston, MA 02114 USA.
   [Cook, Nakela] NHLBI, NIH, Bethesda, MD 20892 USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Harvard University; Harvard
   University Medical Affiliates; Massachusetts General Hospital; National
   Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood
   Institute (NHLBI)
RP Gilstrap, LG (corresponding author), Massachusetts Gen Hosp, Dept Med, 55 Fruit St, Boston, MA 02114 USA.
EM lgilstrap@partners.org
RI Wood, Malissa/T-3201-2019
OI Malhotra, Rajeev/0000-0003-0120-4630
CR [Anonymous], CHRON DIS PREV HLTH
   [Anonymous], HEART DIS STROK PREV
   BURT VL, 1995, HYPERTENSION, V26, P60, DOI 10.1161/01.HYP.26.1.60
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   EAKER ED, 1993, CIRCULATION, V88, P1999, DOI 10.1161/01.CIR.88.4.1999
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Griffin BP, 2006, CLEVELAND CLIN CARDI, P833
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Hanson RL, 2002, DIABETES, V51, P3120, DOI 10.2337/diabetes.51.10.3120
   Hedner T, 1996, Blood Press, V5, P132, DOI 10.3109/08037059609062120
   Kahn R, 2005, LANCET, V366, P1921, DOI 10.1016/S0140-6736(05)67778-1
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   Kahn R, 2008, LANCET, V371, P1892, DOI 10.1016/S0140-6736(08)60731-X
   Lindsay Robert S, 2004, Curr Diab Rep, V4, P63, DOI 10.1007/s11892-004-0013-9
   Manson JE, 2004, ARCH INTERN MED, V164, P249, DOI 10.1001/archinte.164.3.249
   Misra A, 2009, METAB SYNDR RELAT D, V7, P497, DOI 10.1089/met.2009.0024
   Mosca Lori, 2007, Circulation, V115, P1481, DOI 10.1161/CIRCULATIONAHA.107.181546
   Mosca L, 2011, J AM COLL CARDIOL, V57, P1404, DOI [10.1016/j.jacc.2011.02.005, 10.1161/CIR.0b013e31820faaf8]
   Nathan DM, 2009, DIABETES CARE, V32, P1327, DOI 10.2337/dc09-9033
   RADLOFF LS, 1979, J ABNORM PSYCHOL, V88, P174, DOI 10.1037/0021-843X.88.2.174
   Resnick HE, 2003, DIABETES CARE, V26, P861, DOI 10.2337/diacare.26.3.861
   Roger VL, 2012, CIRCULATION, V125, pE2, DOI [10.1161/CIR.0b013e31823ac046, 10.1161/CIR.0b013e3182456d46]
   Sattar N, 2003, CIRCULATION, V108, P414, DOI 10.1161/01.CIR.0000080897.52664.94
   Sjol A, 1998, INT J EPIDEMIOL, V27, P614, DOI 10.1093/ije/27.4.614
   SPIELBERGER CD, 1984, J PERS ASSESS, V48, P95
   Stewart-Knox BJ, 2005, P NUTR SOC, V64, P363, DOI 10.1079/PNS2005444
   Stoddard AM, 2004, J WOMENS HEALTH, V13, P539, DOI 10.1089/1540999041281106
   Vadheim LM, 2010, J RURAL HEALTH, V26, P266, DOI 10.1111/j.1748-0361.2010.00288.x
   Wenger Nanette K, 2002, Cardiol Rev, V10, P211, DOI 10.1097/00045415-200207000-00005
   Will J C, 2001, J Am Med Womens Assoc (1972), V56, P161
   DIABETES CARE S1, V33, pS62
NR 35
TC 22
Z9 24
U1 1
U2 11
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
EI 1931-843X
J9 J WOMENS HEALTH
JI J. Womens Health
PD APR
PY 2013
VL 22
IS 4
BP 322
EP 329
DI 10.1089/jwh.2012.3854
PG 8
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal; Obstetrics & Gynecology; Women's Studies
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal
   Medicine; Obstetrics & Gynecology; Women's Studies
GA 126FZ
UT WOS:000317599700006
PM 23540328
DA 2025-06-11
ER

PT J
AU Jovanovic, J
   Sarac, I
   Martacic, JD
   Oggiano, GP
   Despotovic, M
   Pokimica, B
   Cupi, B
AF Jovanovic, Jovica
   Sarac, Ivana
   Martacic, Jasmina Debeljak
   Oggiano, Gordana Petrovic
   Despotovic, Marta
   Pokimica, Biljana
   Cupi, Blerim
TI The influence of specific aspects of occupational stress on security
   guards' health and work ability: detailed extension of a previous study
SO ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE
   AND TOXICOLOGY
LA English
DT Article
DE cardiovascular diseases; diabetes; hypertension; metabolic syndrome;
   occupational exposure; psychological stress; sick leave
ID ISCHEMIC-HEART-DISEASE; RIDGE-REGRESSION; SHIFT WORK; PRECARIOUS
   EMPLOYMENT; PROFESSIONAL DRIVERS; DIABETES-MELLITUS; LIPID DISORDERS;
   RISK; ENVIRONMENT; ASSOCIATION
AB In our earlier study of security guards, we showed that higher occupational stress was associated with health impairments (metabolic syndrome, diabetes, hypertension, cardiovascular diseases) and work disability. The aim of this study was to further explore the association of specific occupational stressors with health impairments and work disability parameters in 399 Serbian male security guards (aged 25-65 years). Ridge linear regression analysis revealed that, after controlling for age, body mass index, and smoking status, professional stressors including high demands, strictness, conflict/uncertainty, threat avoidance and underload were significant positive predictors of fasting glucose, triglycerides, total and LDL cholesterol, blood pressure, heart rate, Framingham cardiovascular risk score, and temporary work disability. The security profession is in expansion worldwide, and more studies are needed to establish precise health risk predictors, since such data are generally lacking.
C1 [Jovanovic, Jovica; Cupi, Blerim] Univ Nis, Fac Med, Dept Occupat Hlth, Nish, Serbia.
   [Sarac, Ivana; Martacic, Jasmina Debeljak; Oggiano, Gordana Petrovic; Despotovic, Marta; Pokimica, Biljana] Univ Belgrade, Ctr Res Excellence Field Nutr & Metab, Inst Med Res, Natl Inst Republ Serbia, Tadeusa Koscuska 1, Belgrade 11158, Serbia.
   [Jovanovic, Jovica] Inst Occupat Med, Nish, Serbia.
C3 University of Nis; University of Belgrade
RP Sarac, I (corresponding author), Univ Belgrade, Ctr Res Excellence Field Nutr & Metab, Inst Med Res, Natl Inst Republ Serbia, Tadeusa Koscuska 1, Belgrade 11158, Serbia.
EM ivanasarac@yahoo.com
RI Šarac, Ivana/ABR-2387-2022
OI Sarac, Ivana/0000-0003-1439-9561; Despotovic, Marta/0000-0003-0907-3532;
   Debeljak Martacic, Jasmina/0000-0002-9605-3793
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [III41030, III43012, 451-03-68/2020-14/200015]
FX The authors acknowledge financial support from the Ministry of
   Education, Science and Technological Development of the Republic of
   Serbia, projects number III41030 and III43012 (2011-2017), and ongoing
   contract number: 451-03-68/2020-14/200015.
CR Abdel Hamied AM, 2018, J PUB HLTH CATALOG, V1, P101
   Ahmad A, 2012, IJPBS, V2, P237, DOI DOI 10.5923/J.IJPBS.20120206.07
   Ahmad A, 2013, PSYCHOL BEHAV SCI, V2, P130, DOI DOI 10.11648/J.PBS.20130203.18
   ALFREDSSON L, 1991, ERGONOMICS, V34, P525, DOI 10.1080/00140139108967334
   [Anonymous], **DATA OBJECT**
   Arlinghaus A, 2019, IND HEALTH, V57, P184, DOI 10.2486/indhealth.SW-4
   Baeriswyl S, 2016, FRONT PSYCHOL, V7, DOI 10.3389/fpsyg.2016.00663
   Bannai A, 2016, J EPIDEMIOL, V26, P481, DOI 10.2188/jea.JE20150155
   Barbini N, 2017, ARCH CLIN HYPERTENS, V3, DOI [10.17352/ach.000011, DOI 10.17352/ACH.000011]
   Baron KG, 2017, INT J OBESITY, V41, P203, DOI 10.1038/ijo.2016.194
   Bazana S., 2016, New Voices in Psychology, V12, P70, DOI DOI 10.25159/1812-6371/2783
   Begani R., 2013, Contemporary PNG Studies: DWU Research, V18, P98
   Belkic K., 2003, The occupational stress index: An approach derived from cognitive ergonomics and brain research for clinical practice
   Belkic K, 2008, SCAND J WORK ENV HEA, P169
   Belkic Karen, 2014, Med Pregl, V67, P139
   Benach J, 2014, ANNU REV PUBL HEALTH, V35, P229, DOI 10.1146/annurev-publhealth-032013-182500
   Bland M., 1995, INTRO MED STAT, V2nd
   Bogaerts S., 2011, CRIMEN DELICTUM INT, V2, P44
   Bogaerts S, 2009, PSYCHOL REP, V105, P889, DOI 10.2466/PR0.105.3.889-899
   Booth FW, 2012, COMPR PHYSIOL, V2, P1143, DOI 10.1002/cphy.c110025
   Boullosa DA, 2015, ROLE PHYS FITNESS CA, DOI [10.3389/978-2-88919-463-6, DOI 10.3389/978-2-88919-463-6]
   Burazor I, 2011, J CLIN LIPIDOL, V5, P230, DOI DOI 10.1016/J.JACL.2011.03.060
   Caldbick S, 2014, GLOB HEALTH PROMOT, V21, P23, DOI 10.1177/1757975913514781
   Cappuccio FP, 2017, CURR CARDIOL REP, V19, DOI 10.1007/s11886-017-0916-0
   Cefalu WT, 2019, DIABETES CARE, V42, pS13, DOI 10.2337/dc19-S002
   Chaichi A., 2016, International Journal of Human Capital in Urban Management, V1, P199, DOI DOI 10.22034/IJHCUM.2016.01.03.006
   Copertaro A, 2019, IND HEALTH, V57, P557, DOI 10.2486/indhealth.2018-0173
   Cule E, 2020
   Cule E, 2012, ARXIV12050686V1STATA
   Cule E, 2013, GENET EPIDEMIOL, V37, P704, DOI 10.1002/gepi.21750
   D'Agostino RB, 2008, CIRCULATION, V117, P743, DOI 10.1161/CIRCULATIONAHA.107.699579
   Dang C, 2016, INT ARCH OCC ENV HEA, V89, P755, DOI 10.1007/s00420-016-1113-y
   Dashti HS, 2015, DIABETES CARE, V38, P1456, DOI 10.2337/dc14-2709
   Declercq F, 2007, J CLIN PSYCHOL, V63, P1239, DOI 10.1002/jclp.20426
   Djindjic N, 2013, VOJNOSANIT PREGL, V70, P561, DOI 10.2298/VSP1306561D
   Djindjic N, 2012, ANN OCCUP HYG, V56, P1051, DOI 10.1093/annhyg/mes059
   Dogan B, 2016, RIV PSICHIATR, V51, P72, DOI 10.1708/2246.24200
   du Toit D, 2015, S AFR REV SOCIOL, V46, P97, DOI 10.1080/21528586.2014.999112
   Duzan H., 2015, J APPL SCI, V15, P392, DOI [10.3923/jas.2015.392.404, DOI 10.3923/jas.2015.392.404]
   European Agency for Safety and Health at Work (EU -OSHA), 2007, EXPERT FORECAST EMER, pDecember 2019] Available
   Ferguson P., 2011, International Journal of Police Science Management, V13, P223, DOI DOI 10.1350/IJPS.2011.13.3.239
   Fishta A, 2015, INT ARCH OCC ENV HEA, V88, P997, DOI 10.1007/s00420-015-1019-0
   Godinho MR, 2016, REV LAT-AM ENFERM, V24, DOI 10.1590/1518-8345.0616.2725
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Hattori T, 2015, IND HEALTH, V53, P480, DOI 10.2486/indhealth.2014-0205
   Hsu YY, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/5046934
   Jacob Louis, 2017, Ger Med Sci, V15, pDoc08, DOI 10.3205/000249
   James Stephen M, 2017, Curr Sleep Med Rep, V3, P104, DOI 10.1007/s40675-017-0071-6
   Jankowiak S, 2016, INT ARCH OCC ENV HEA, V89, P1169, DOI 10.1007/s00420-016-1150-6
   Salvagioni DAJ, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0185781
   Jood K, 2017, SCAND J WORK ENV HEA, V43, P367, DOI 10.5271/sjweh.3636
   Jovanovic J, 2021, INT J OCCUP SAF ERGO, V27, P425, DOI 10.1080/10803548.2019.1579458
   Jovanovic Jovica, 2008, Central European Journal of Public Health, V16, P54
   Jovanovic S, 2017, ACTA MED MEDIANAE, V56, P129, DOI [10.5633/amm.2017.0320, DOI 10.5633/AMM.2017.0320]
   Kervezee L, 2019, PLOS BIOL, V17, DOI 10.1371/journal.pbio.3000303
   Kervezee L, 2020, EUR J NEUROSCI, V51, P396, DOI 10.1111/ejn.14216
   Khalil Asem, 2007, Entry-Points for Palestinian Security Sector Reform, P31
   Kivimäki M, 2015, LANCET DIABETES ENDO, V3, P27, DOI 10.1016/S2213-8587(14)70178-0
   Koeppen BC, 2019, THESIS
   Lane JM, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms10889
   Latza U, 2015, INT ARCH OCC ENV HEA, V88, P1087, DOI 10.1007/s00420-015-1030-5
   Laureys VAS, 2019, POLICING, V42, P126, DOI 10.1108/PIJPSM-09-2017-0114
   Lazaridis K, 2017, INT J OCCUP SAF ERGO, V23, P259, DOI 10.1080/10803548.2016.1179524
   Leino TM, 2013, PEOPLE WORK
   Leino T, 2011, IND HEALTH, V49, P143, DOI 10.2486/indhealth.MS1208
   Leow S, 2018, NUTRIENTS, V10, DOI 10.3390/nu10020176
   Liu CQ, 2015, AM J PHYSIOL-HEART C, V309, pH1793, DOI 10.1152/ajpheart.00199.2015
   Martin A, 2016, STRESS HEALTH, V32, P201, DOI 10.1002/smi.2593
   McHill AW, 2017, OBES REV, V18, P15, DOI 10.1111/obr.12503
   McHill AW, 2017, AM J CLIN NUTR, V106, P1213, DOI 10.3945/ajcn.117.161588
   Moy F M, 2008, Malays J Nutr, V14, P57
   Moy F, 2006, HEALTH PROMOT INT, V21, P301, DOI 10.1093/heapro/dal031
   Münzel T, 2017, EUR HEART J, V38, P550, DOI 10.1093/eurheartj/ehw269
   Muratsubaki T, 2016, CHINESE MED J-PEKING, V129, P2409, DOI 10.4103/0366-6999.191750
   Mutambudzi M, 2016, J GERONTOL B-PSYCHOL, V71, P1089, DOI 10.1093/geronb/gbw091
   Nätti J, 2015, OCCUP ENVIRON MED, V72, P265, DOI 10.1136/oemed-2014-102435
   Nedic O, 2008, MED PREGL, V61, P22, DOI [DOI 10.2298/MPNS0806226N, 10.2298/mpns0806226n]
   Nielsen MB, 2020, INT ARCH OCC ENV HEA, V93, P43, DOI 10.1007/s00420-019-01463-y
   Nisha Y, 2015, J STUD MANAG PLANN
   Noh J, 2018, J OBES METAB SYNDR, V27, P78, DOI 10.7570/jomes.2018.27.2.78
   Paese A., 2014, International Journal of Psycholog6y and Behavioral Sciences, V4, P113
   Pattnaik R., 2016, Indian Journal of Positive Psychology, V7, P172
   Peduzzi P, 1996, J CLIN EPIDEMIOL, V49, P1373, DOI 10.1016/S0895-4356(96)00236-3
   Pereira JM, 2016, PROC ECON FINANC, V39, P634, DOI 10.1016/S2212-5671(16)30310-0
   Pettersson Hans, 2020, Int Arch Occup Environ Health, V93, P571, DOI 10.1007/s00420-019-01513-5
   Qi MM, 2016, FRONT PSYCHOL, V7, DOI 10.3389/fpsyg.2016.00229
   Raffaelli Q, 2018, EXP BRAIN RES, V236, P2451, DOI 10.1007/s00221-017-4922-7
   Reisel W.D., 2010, International Studies of Management Organization, V40, P74, DOI DOI 10.2753/IMO0020-8825400105
   Roglic G, 2016, Global report on psoriasis
   Saleem A., 2017, Pakistan Journal of Social and Clinical Psychology, V15, P29
   Sefalafala T, 2013, S AFR REV SOCIOL, V44, P76, DOI 10.1080/21528586.2013.802539
   Shaidah JB, 2016, THESIS
   Shockey TM, 2017, MMWR-MORBID MORTAL W, V66, P7, DOI 10.15585/mmwr.mm6608a2
   Siegrist J, 2017, INT J ENV RES PUB HE, V14, DOI 10.3390/ijerph14111373
   Skene DJ, 2018, P NATL ACAD SCI USA, V115, P7825, DOI 10.1073/pnas.1801183115
   Suginraj M., 2016, International Journal of Research, V4, P12
   Sun M, 2018, OBES REV, V19, P28, DOI 10.1111/obr.12621
   Swedish Council on Health Technology Assessment, 2015, 240 SBU SWED COUNC H
   Talas R, 2021, POLIC SOC, V31, P321, DOI 10.1080/10439463.2020.1739047
   Tan X., 2016, J SAINS KESIHAT MALA, V14, P31, DOI [DOI 10.17576/JSKM-2016-1402-04, 10.17576/jskm-2016-1402-04]
   Terpstra J, 2016, POLIC SOC, V26, P77, DOI 10.1080/10439463.2014.942843
   The Danish Institute for Human Rights and DCAF -Geneva Centre for Security Sector Governance, 2019, PRIV SEC GOV NAT ACT
   Theorell T, 2016, EUR J PUBLIC HEALTH, V26, P470, DOI 10.1093/eurpub/ckw025
   Torquati L, 2018, SCAND J WORK ENV HEA, V44, P229, DOI 10.5271/sjweh.3700
   Trudel X, 2020, HYPERTENSION, V75, P532, DOI 10.1161/HYPERTENSIONAHA.119.12926
   van Hooft EAJ, 2018, MOTIV EMOTION, V42, P931, DOI 10.1007/s11031-018-9710-6
   Vanheule S, 2009, PERS INDIV DIFFER, V46, P374, DOI 10.1016/j.paid.2008.10.015
   Vanheule S, 2008, STRESS HEALTH, V24, P137, DOI 10.1002/smi.1177
   Virtanen M, 2018, CURR CARDIOL REP, V20, DOI 10.1007/s11886-018-1049-9
   Wang MJ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0096025
   Wong K, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16122102
   Xu TW, 2019, EUR HEART J, V40, P1124, DOI 10.1093/eurheartj/ehy683
   Xu TW, 2018, DIABETOLOGIA, V61, P75, DOI 10.1007/s00125-017-4480-3
   Zamanian Z., 2012, INT J OCCUPAT HYGIEN, V4, P39
   Zhao I, 2008, AUST J ADV NURS, V25, P8
NR 116
TC 5
Z9 6
U1 2
U2 10
PU SCIENDO
PI WARSAW
PA BOGUMILA ZUGA 32A, WARSAW, MAZOVIA, POLAND
SN 0004-1254
EI 1848-6312
J9 ARH HIG RADA TOKSIKO
JI Arh. Hig. Rada. Toksikol.
PD DEC
PY 2020
VL 71
IS 4
BP 359
EP 374
DI 10.2478/aiht-2020-71-3379
PG 16
WC Public, Environmental & Occupational Health; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Toxicology
GA PP4OI
UT WOS:000605843200009
PM 33410781
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Robson, PJ
   Guy, GW
   Di Marzo, V
AF Robson, P. J.
   Guy, G. W.
   Di Marzo, V.
TI Cannabinoids and Schizophrenia: Therapeutic Prospects
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Phytocannabinoids; endocannabinoid system; schizophrenia;
   anti-psychotic; metabolic effects; chronic inflammation; stress
ID PLASMA ENDOCANNABINOID LEVELS; CARDIOMETABOLIC RISK-FACTORS;
   CORONARY-ARTERY-DISEASE; PITUITARY-ADRENAL AXIS; LONG-TERM TREATMENT;
   NEUROTROPHIC FACTOR; METABOLIC SYNDROME; DIABETES-MELLITUS; CB1
   RECEPTORS; ATYPICAL ANTIPSYCHOTICS
AB Approximately one third of patients diagnosed with schizophrenia do not achieve adequate symptom control with standard antipsychotic drugs (APs). Some of these may prove responsive to clozapine, but non-response to APs remains an important clinical problem and cause of increased health care costs.
   In a significant proportion of patients, schizophrenia is associated with natural and iatrogenic metabolic abnormalities (obesity, dyslipidaemia, impaired glucose tolerance or type 2 diabetes mellitus), hyperadrenalism and an exaggerated HPA response to stress, and chronic systemic inflammation.
   The endocannabinoid system (ECS) in the brain plays an important role in maintaining normal mental health. ECS modulates emotion, reward processing, sleep regulation, aversive memory extinction and HPA axis regulation. ECS overactivity contributes to visceral fat accumulation, insulin resistance and impaired energy expenditure.
   The cannabis plant synthesises a large number of pharmacologically active compounds unique to it known as phytocannabinoids. In contrast to the euphoric and pro-psychotic effects of delta-9-tetrahydrocannabinol (THC), certain non-intoxicating phytocannabinoids have emerged in pre-clinical and clinical models as potential APs. Since the likely mechanism of action does not rely upon dopamine D-2 receptor antagonism, synergistic combinations with existing APs are plausible.
   The anti-inflammatory and immunomodulatory effects of the non-intoxicating phytocannabinoid cannabidiol (CBD) are well established and are summarised below. Preliminary data reviewed in this paper suggest that CBD in combination with a CB1 receptor neutral antagonist could not only augment the effects of standard APs but also target the metabolic, inflammatory and stress-related components of the schizophrenia phenotype.
C1 [Robson, P. J.; Guy, G. W.; Di Marzo, V.] GW Pharmaceut Plc, Salisbury SP4 0JQ, Wilts, England.
   [Robson, P. J.] Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford OX3 7JX, England.
   [Di Marzo, V.] CNR, Inst Biomol Chem, Endocannabinoid Res Grp, I-80078 Pozzuoli, NA, Italy.
C3 University of Oxford; Consiglio Nazionale delle Ricerche (CNR)
RP Robson, PJ (corresponding author), GW Pharmaceut Plc, Cannabinoid Res Inst, Porton Sci Pk, Salisbury SP4 0JQ, Wilts, England.
EM pjr@gwpharm.com
RI Di Marzo, Vincenzo/AAD-7742-2019
OI Di Marzo, Vincenzo/0000-0002-1490-3070
CR Abeywardena Mahinda Y., 2011, Endocrine Metabolic & Immune Disorders-Drug Targets, V11, P232
   ALBUS M, 1982, PSYCHIAT RES, V6, P361, DOI 10.1016/0165-1781(82)90026-9
   Ascher-Svanum H, 2008, SCHIZOPHRENIA BULL, V34, P1163, DOI 10.1093/schbul/sbm134
   BANKI CM, 1987, AM J PSYCHIAT, V144, P873
   Banni S, 2010, MOL NUTR FOOD RES, V54, P82, DOI 10.1002/mnfr.200900516
   Bhattacharyya S, 2012, ARCH GEN PSYCHIAT, V69, P27, DOI 10.1001/archgenpsychiatry.2011.161
   Bhattacharyya S, 2010, NEUROPSYCHOPHARMACOL, V35, P764, DOI 10.1038/npp.2009.184
   Bisogno T, 2001, BRIT J PHARMACOL, V134, P845, DOI 10.1038/sj.bjp.0704327
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   Black MD, 2011, PSYCHOPHARMACOLOGY, V215, P149, DOI 10.1007/s00213-010-2124-0
   Blüher M, 2006, DIABETES, V55, P3053, DOI 10.2337/db06-0812
   Bosi DC, 2003, J PSYCHOPHARMACOL, V17, pA55
   Bushe C, 2004, BRIT J PSYCHIAT, V184, pS67, DOI 10.1192/bjp.184.47.s67
   Carrier EJ, 2006, P NATL ACAD SCI USA, V103, P7895, DOI 10.1073/pnas.0511232103
   Cawthorne M, 2008, 18 ANN S CANN INT CA
   Cazzullo CL, 2002, PROG NEURO-PSYCHOPH, V26, P33, DOI 10.1016/S0278-5846(01)00221-4
   Christopoulou FD, 2011, J CLIN PHARM THER, V36, P10, DOI 10.1111/j.1365-2710.2010.01164.x
   Corcoran C, 2003, SCHIZOPHRENIA BULL, V29, P671, DOI 10.1093/oxfordjournals.schbul.a007038
   Côté M, 2007, INT J OBESITY, V31, P692, DOI 10.1038/sj.ijo.0803539
   Croci T, 2003, BRIT J PHARMACOL, V140, P115, DOI 10.1038/sj.bjp.0705412
   Croxford JL, 2005, J NEUROIMMUNOL, V166, P3, DOI 10.1016/j.jneuroim.2005.04.023
   Dadheech Gora, 2008, Indian J Psychiatry, V50, P16, DOI 10.4103/0019-5545.39753
   De Marchi Nicola, 2003, Lipids Health Dis, V2, P5, DOI 10.1186/1476-511X-2-5
   de Nayer A, 2007, ENCEPHALE, V33, P197
   De Petrocellis L, 2010, J NEUROIMMUNE PHARM, V5, P103, DOI 10.1007/s11481-009-9177-z
   Dean B, 2001, NEUROSCIENCE, V103, P9, DOI 10.1016/S0306-4522(00)00552-2
   Di Marzo V, 2009, DIABETOLOGIA, V52, P213, DOI 10.1007/s00125-008-1178-6
   Di Marzo V, 2008, DIABETOLOGIA, V51, P1356, DOI 10.1007/s00125-008-1048-2
   Di Marzo V, 2009, EUR J ENDOCRINOL, V161, P715, DOI 10.1530/EJE-09-0643
   Di Marzo V, 2009, NAT REV ENDOCRINOL, V5, P633, DOI 10.1038/nrendo.2009.197
   Dinan T, 2004, BRIT J PSYCHIAT, V184, pS112
   Dinan TG, 2004, BRIT J PSYCHIAT, V184, pS72, DOI 10.1192/bjp.184.47.s72
   Doyon C, 2006, DIABETES, V55, P3403, DOI 10.2337/db06-0504
   Emrich HM, 1997, PHARMACOL BIOCHEM BE, V56, P803, DOI 10.1016/S0091-3057(96)00426-1
   Englund Amir, 2013, J Psychopharmacol, V27, P19, DOI 10.1177/0269881112460109
   Falcone T, 2009, PSYCHIAT TIMES, V26
   Fan Xiaoduo, 2007, Expert Rev Neurother, V7, P789, DOI 10.1586/14737175.7.7.789
   Ferre S, 1997, PSYCHOPHARMACOLOGY, V133, P107, DOI 10.1007/s002130050380
   Frommberger UH, 1997, EUR ARCH PSY CLIN N, V247, P228, DOI 10.1007/BF02900219
   Gentile S, 2006, DRUG SAFETY, V29, P303, DOI 10.2165/00002018-200629040-00002
   Giuffrida A, 2004, NEUROPSYCHOPHARMACOL, V29, P2108, DOI 10.1038/sj.npp.1300558
   Gorski JA, 2003, J NEUROSCI, V23, P6856
   Gorzalka BB, 2008, NEUROSCI BIOBEHAV R, V32, P1152, DOI 10.1016/j.neubiorev.2008.03.004
   Guidali C, 2011, INT J NEUROPSYCHOPH, V14, P17, DOI 10.1017/S1461145710000209
   Hanson DR, 2005, BMC MED GENET, V6, DOI 10.1186/1471-2350-6-7
   Heyman E, 2012, PSYCHONEUROENDOCRINO, V37, P844, DOI 10.1016/j.psyneuen.2011.09.017
   Hill MN, 2012, NEUROSCIENCE, V204, P5, DOI 10.1016/j.neuroscience.2011.12.030
   Hill MN, 2009, CNS NEUROL DISORD-DR, V8, P451, DOI 10.2174/187152709789824624
   Hill MN, 2005, BEHAV PHARMACOL, V16, P333, DOI 10.1097/00008877-200509000-00006
   Hill MN, 2005, NEUROPSYCHOPHARMACOL, V30, P508, DOI 10.1038/sj.npp.1300601
   Holt RIG, 2004, DIABETIC MED, V21, P515, DOI 10.1111/j.1464-5491.2004.01199.x
   Isaac M, 2007, BRIT J PSYCHIAT, V191, pS71, DOI 10.1192/bjp.191.50.s71
   Izzo AA, 2009, BRIT J PHARMACOL, V158, P451, DOI 10.1111/j.1476-5381.2009.00183.x
   JAVITT DC, 1995, ARCH GEN PSYCHIAT, V52, P550
   Juckel G, 2007, SCHIZOPHR RES, V97, P109, DOI 10.1016/j.schres.2007.08.015
   Justo D, 2006, ACTA PSYCHIAT SCAND, V113, P245, DOI 10.1111/j.1600-0447.2006.00761.x
   Kallmann FJ, 1943, J HERED, V34, P293, DOI 10.1093/oxfordjournals.jhered.a105222
   KANE J, 1988, ARCH GEN PSYCHIAT, V45, P789
   KARNIOL IG, 1973, PSYCHOPHARMACOLOGIA, V33, P53, DOI 10.1007/BF00428793
   Kendall T, 2011, BRIT J PSYCHIAT, V199, P266, DOI 10.1192/bjp.bp.110.083766
   Kim JJ, 1998, TRENDS NEUROSCI, V21, P505, DOI 10.1016/S0166-2236(98)01322-8
   Koethe D, 2009, BRIT J PSYCHIAT, V194, P371, DOI 10.1192/bjp.bp.108.053843
   Kohen D, 2004, BRIT J PSYCHIAT, V184, pS64, DOI 10.1192/bjp.184.47.s64
   Koola MM, 2012, J PSYCHIATR RES, V46, P987, DOI 10.1016/j.jpsychires.2012.04.019
   Kreitzer AC, 2005, CURR BIOL, V15, pR549, DOI 10.1016/j.cub.2005.07.005
   Lambert MT, 2006, PROG NEURO-PSYCHOPH, V30, P919, DOI 10.1016/j.pnpbp.2006.02.007
   Lara DR, 2006, PROG NEURO-PSYCHOPH, V30, P617, DOI 10.1016/j.pnpbp.2006.02.002
   Le Foll B, 2009, PSYCHOPHARMACOLOGY, V205, P171, DOI 10.1007/s00213-009-1506-7
   Leonard Brian E, 2005, Expert Rev Clin Immunol, V1, P103, DOI 10.1586/1744666X.1.1.103
   Leweke FM, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.15
   Leweke FM, 2000, PHARMACOL BIOCHEM BE, V66, P175, DOI 10.1016/S0091-3057(00)00201-X
   LINDSTROM LH, 1988, ACTA PSYCHIAT SCAND, V77, P524, DOI 10.1111/j.1600-0447.1988.tb05164.x
   Long LE, 2006, NEUROPSYCHOPHARMACOL, V31, P795, DOI 10.1038/sj.npp.1300838
   Long LE, 2006, 16 ANN S CANN INT CA
   Lutz B, 2009, CURR OPIN PHARMACOL, V9, P46, DOI 10.1016/j.coph.2008.12.001
   Mackie K, 2005, HANDB EXP PHARMACOL, V168, P299
   Malfait AM, 2000, P NATL ACAD SCI USA, V97, P9561, DOI 10.1073/pnas.160105897
   Marsicano G, 2003, SCIENCE, V302, P84, DOI 10.1126/science.1088208
   Martins JM, 2001, INT J OBESITY, V25, P24, DOI 10.1038/sj.ijo.0801500
   Matias I, 2008, MOL CELL ENDOCRINOL, V286, pS66, DOI 10.1016/j.mce.2008.01.026
   Matias I, 2006, J CLIN ENDOCR METAB, V91, P3171, DOI 10.1210/jc.2005-2679
   McEvoy JP, 2005, SCHIZOPHR RES, V80, P19, DOI 10.1016/j.schres.2005.07.014
   Mellor JE, 1996, HUM PSYCHOPHARM CLIN, V11, P39, DOI 10.1002/(SICI)1099-1077(199601)11:1<39::AID-HUP742>3.0.CO;2-#
   Meltzer HY, 2004, AM J PSYCHIAT, V161, P975, DOI 10.1176/appi.ajp.161.6.975
   Meyer G, 2003, MED KLIN, V98, P266, DOI 10.1007/s00063-003-1255-z
   Miyamoto S, 2005, MOL PSYCHIATR, V10, P79, DOI 10.1038/sj.mp.4001556
   Molteni R, 2002, NEUROSCIENCE, V112, P803, DOI 10.1016/S0306-4522(02)00123-9
   Morgan CJA, 2008, BRIT J PSYCHIAT, V192, P306, DOI 10.1192/bjp.bp.107.046649
   Morgan CJA, 2010, BRIT J PSYCHIAT, V197, P285, DOI 10.1192/bjp.bp.110.077503
   Morgan CJA, 2010, NEUROPSYCHOPHARMACOL, V35, P1879, DOI 10.1038/npp.2010.58
   Morrison PD, 2011, HUM PSYCHOPHARM CLIN, V26, P77, DOI 10.1002/hup.1166
   Muller-Vahl Kirsten R, 2008, Expert Rev Neurother, V8, P1037, DOI 10.1586/14737175.8.7.1037
   Newcomer JW, 2006, CAN J PSYCHIAT, V51, P480, DOI 10.1177/070674370605100803
   Nissen SE, 2008, JAMA-J AM MED ASSOC, V299, P1547, DOI 10.1001/jama.299.13.1547
   Osei-Hyiaman D, 2005, J CLIN INVEST, V115, P1298, DOI 10.1172/JCI200523057
   Pacher P, 2006, PHARMACOL REV, V58, P389, DOI 10.1124/pr.58.3.2
   Patel S, 2004, ENDOCRINOLOGY, V145, P5431, DOI 10.1210/en.2004-0638
   Peet M, 2005, DRUGS, V65, P1051, DOI 10.2165/00003495-200565080-00002
   Peet M, 2004, BRIT J PSYCHIAT, V184, pS102, DOI 10.1192/bjp.184.47.s102
   Peet M, 2006, PROSTAG LEUKOTR ESS, V75, P323, DOI 10.1016/j.plefa.2006.07.013
   Pertwee RG, 2006, BRIT J PHARMACOL, V147, pS163, DOI 10.1038/sj.bjp.0706406
   Pertwee RG, 2005, HANDB EXP PHARMACOL, V168, P1
   Pertwee RG, 2004, NEUROSCI INTELL UNIT, P32
   Potter DJ, 2008, J FORENSIC SCI, V53, P90, DOI 10.1111/j.1556-4029.2007.00603.x
   Potvin S, 2008, SCHIZOPHR RES, V100, P242, DOI 10.1016/j.schres.2007.04.022
   Prabakaran S, 2004, MOL PSYCHIATR, V9, P684, DOI 10.1038/sj.mp.4001511
   Rajavashisth TB, 2012, BMJ OPEN, V2, DOI 10.1136/bmjopen-2011-000494
   Resstel LBM, 2009, BRIT J PHARMACOL, V156, P181, DOI 10.1111/j.1476-5381.2008.00046.x
   Riebe CJ, 2011, STRESS, V14, P384, DOI 10.3109/10253890.2011.586753
   Riedel G, 2009, BRIT J PHARMACOL, V156, P1154, DOI 10.1111/j.1476-5381.2008.00107.x
   Roerig JL, 2011, CNS DRUGS, V25, P1035, DOI 10.2165/11596300-000000000-00000
   Roser P, 2010, WORLD J BIOL PSYCHIA, V11, P208, DOI 10.3109/15622970801908047
   Rosmond R, 1998, INT J OBESITY, V22, P1184, DOI 10.1038/sj.ijo.0800745
   ROTTANBURG D, 1982, LANCET, V2, P1364
   Ryan MCM, 2002, LIFE SCI, V71, P239, DOI 10.1016/S0024-3205(02)01646-6
   Schubart CD, 2011, SCHIZOPHR RES, V130, P216, DOI 10.1016/j.schres.2011.04.017
   Shiloah E, 2003, DIABETES CARE, V26, P1462, DOI 10.2337/diacare.26.5.1462
   Smith M, 2008, BRIT J PSYCHIAT, V192, P406, DOI 10.1192/bjp.bp.107.037184
   Sommer IE, 2012, J CLIN PSYCHIAT, V73, P414, DOI 10.4088/JCP.10r06823
   Starowicz K, 2007, PHARMACOL THERAPEUT, V114, P13, DOI 10.1016/j.pharmthera.2007.01.005
   Steiner MA, 2008, PHARMACOGENOMICS J, V8, P196, DOI 10.1038/sj.tpj.6500466
   Steiner MA, 2008, PROG BRAIN RES, V170, P397, DOI 10.1016/S0079-6123(08)00433-0
   Stöger R, 2008, BIOESSAYS, V30, P156, DOI 10.1002/bies.20700
   Sugamura K, 2009, CIRCULATION, V119, P28, DOI 10.1161/CIRCULATIONAHA.108.811992
   Szekeres G, 2003, SCHIZOPHR RES, V65, P15, DOI 10.1016/S0920-9964(02)00505-4
   Thakore JH, 2005, BRIT J PSYCHIAT, V186, P455, DOI 10.1192/bjp.186.6.455
   Thakore JH, 2004, BRIT J PSYCHIAT, V184, pS76, DOI 10.1192/bjp.184.47.s76
   Thakore JH, 2002, INT J OBESITY, V26, P137, DOI 10.1038/sj.ijo.0801840
   Thomas A, 2005, BRIT J PHARMACOL, V146, P917, DOI 10.1038/sj.bjp.0706414
   THONNARDNEUMANN E, 1968, AM J PSYCHIAT, V124, P978, DOI 10.1176/ajp.124.7.978
   Topol EJ, 2010, LANCET, V376, P517, DOI 10.1016/S0140-6736(10)60935-X
   Ücok A, 2008, WORLD PSYCHIATRY, V7, P58
   Valverde O, 2005, HANDB EXP PHARMACOL, V168, P117
   Van Gaal L, 2008, DIABETES CARE, V31, pS229, DOI 10.2337/dc08-s258
   Vigano D, 2009, INT J NEUROPSYCHOPH, V12, P599, DOI 10.1017/S1461145708009371
   Walder DJ, 2000, BIOL PSYCHIAT, V48, P1121, DOI 10.1016/S0006-3223(00)01052-0
   Webster MJ, 2002, DEV BRAIN RES, V139, P139, DOI 10.1016/S0165-3806(02)00540-0
   Weickert CS, 2003, MOL PSYCHIATR, V8, P592, DOI 10.1038/sj.mp.4001308
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Wersching H, 2010, NEUROLOGY, V74, P1022, DOI 10.1212/WNL.0b013e3181d7b45b
   Weston-Green K, 2008, INT J NEUROPSYCHOPH, V11, P827, DOI 10.1017/S1461145708008560
   Weston-Green K, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033548
   YAO JK, 1994, PSYCHIAT RES, V54, P13, DOI 10.1016/0165-1781(94)90061-2
   Zahrzewska KE, 1997, DIABETES, V46, P717
   ZALCMAN S, 1994, BRAIN RES, V643, P40, DOI 10.1016/0006-8993(94)90006-X
   Zavitsanou K, 2004, PROG NEURO-PSYCHOPH, V28, P355, DOI 10.1016/j.pnpbp.2003.11.005
   Zhang XY, 2004, J CLIN PSYCHIAT, V65, P940
   Zhang ZJ, 2004, BRIT J PSYCHIAT, V184, P58, DOI 10.1192/bjp.184.1.58
   Zoppi S, 2011, NEUROPSYCHOPHARMACOL, V36, P805, DOI 10.1038/npp.2010.214
   Zorrilla EP, 1996, BIOL PSYCHIAT, V40, P825, DOI 10.1016/0006-3223(95)00598-6
   Zuardi AW, 2008, REV BRAS PSIQUIATR, V30, P271, DOI 10.1590/S1516-44462008000300015
   Zuardi AW, 2006, J PSYCHOPHARMACOL, V20, P683, DOI 10.1177/0269881106060967
   ZUARDI AW, 1991, PSYCHOPHARMACOLOGY, V104, P260, DOI 10.1007/BF02244189
   ZUARDI AW, 1982, PSYCHOPHARMACOLOGY, V76, P245, DOI 10.1007/BF00432554
   ZUARDI AW, 1995, J CLIN PSYCHIAT, V56, P485
NR 155
TC 20
Z9 22
U1 1
U2 40
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD APR
PY 2014
VL 20
IS 13
BP 2194
EP 2204
DI 10.2174/13816128113199990427
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AH3UO
UT WOS:000336051300010
PM 23829368
DA 2025-06-11
ER

PT J
AU Marculescu, F
   Antonia, R
   Albulescu, D
   Popescu, M
   Tutunaru, C
   Patrascommacu, V
AF Marculescu, Florentina
   Antonia, Radu
   Albulescu, Dana
   Popescu, Mihaela
   Tutunaru, Cristina
   Patrascommacu, Virgil
TI PREVALENCE OF PSYCHIATRIC COMORBIDITIES IN PATIENTS WITH PSORIASIS AND
   THEIR EVOLUTION UNDER TREATMENT
SO FARMACIA
LA English
DT Article
DE psoriasis; depression; anxiety; treatment
ID STRUCTURED INTERVIEW GUIDE; PANIC DISORDER; DEPRESSION; MELATONIN;
   ANXIETY; DISEASE; IMPACT; LIFE
AB Psoriasis is a chronic, immune-mediated inflammatory dermatosis that associates a number of conditions such as cardiovascular disease, metabolic syndrome, inflammatory bowel disease, neoplasia or psychiatric disorders, amongst the most frequent being depression and anxiety. This article aims to highlight the common pathogenetic pathway between psoriasis and psychiatric comorbidities, depression and anxiety, their prevalence among psoriasis patients, as well as the evolution of these conditions under psoriasis-specific systemic therapy (biological therapy and conventional systemic therapy) using specific scales to quantify depression severity and anxiety (HAM-D, HAM-A), determined at a certain time interval after the initiation of therapies. We conducted an observational study in the Dermatology Department of the Slatina Emergency County Hospital on a group of 51 patients clinically diagnosed with psoriasis. Thus, we found that the degree of mental impairment in the studied group was significant, 49% of patients showed mild depression, 15.7% moderate depressive episodes and 5.9% severe depression. Only 29.4% were not affected by depression. In terms of anxiety, 21.6% had moderate anxiety. Psoriasis is a chronic condition associated with the secretion of numerous pro-inflammatory cytokines. Increased levels of pro-inflammatory cytokines are also found in major depressive disorders. Thus, the common pathogenic pathway between psoriasis and depression may be the overexpression of proinflammatory cytokines such as IL-6, IL-17 or TNF-alpha. In the last two decades, with the advent of biological therapies, the treatment of psoriasis has evolved dramatically, and they have also had a positive impact on comorbidities, particularly psychiatric ones.
C1 [Marculescu, Florentina; Tutunaru, Cristina; Patrascommacu, Virgil] Univ Med & Pharm Craiova, Dept Dermatol, Craiova, Romania.
   [Marculescu, Florentina] Emergency Cty Hosp, Dept Dermatol, Slatina, Romania.
   [Antonia, Radu] Univ Med & Pharm Craiova, Dept Pharmaceut Bot, Craiova, Romania.
   [Albulescu, Dana] Univ Med & Pharm Craiova, Dept Radiol, Craiova, Romania.
   [Popescu, Mihaela] Univ Med & Pharm Craiova, Dept Endocrinol, Craiova, Romania.
   [Tutunaru, Cristina; Patrascommacu, Virgil] Emergency Cty Hosp, Dept Dermatol, Craiova, Romania.
C3 University of Medicine & Pharmacy of Craiova; University of Medicine &
   Pharmacy of Craiova; University of Medicine & Pharmacy of Craiova;
   University of Medicine & Pharmacy of Craiova
RP Albulescu, D (corresponding author), Univ Med & Pharm Craiova, Dept Radiol, Craiova, Romania.
EM dana.albulescu@umfcv.ro
RI Popescu, Sanda/B-9014-2011; albulescu, dana/AAS-9895-2020
CR Almaaytah A, 2022, FARMACIA, V70, P379, DOI 10.31925/farmacia.2022.3.1
   Augustin M, 2020, JAMA DERMATOL, V156, P1344, DOI 10.1001/jamadermatol.2020.3617
   Bruce SE, 2005, AM J PSYCHIAT, V162, P1179, DOI 10.1176/appi.ajp.162.6.1179
   Bulat Vedrana, 2020, Psychiatr Danub, V32, P553
   Carrillo-Vico A, 2013, INT J MOL SCI, V14, P8638, DOI 10.3390/ijms14048638
   Ciobanu AM, 2021, FARMACIA, V69, P555, DOI 10.31925/farmacia.2021.3.19
   Connor CJ, 2015, DERMAT RES PRACT, V2015, DOI 10.1155/2015/409637
   Davami MH, 2016, BASIC CLIN NEUROSCI, V7, P137, DOI 10.15412/J.BCN.03070207
   Davidoff J, 2012, QUAL LIFE RES, V21, P945, DOI 10.1007/s11136-011-0020-7
   Esposito E, 2010, CURR NEUROPHARMACOL, V8, P228, DOI 10.2174/157015910792246155
   Ferreira Barbara Isabel Roque Cunha, 2016, J Clin Aesthet Dermatol, V9, P36
   González-Cantero A, 2021, J INVEST DERMATOL, V141, P2402, DOI 10.1016/j.jid.2021.03.024
   Gordon KB, 2018, J EUR ACAD DERMATOL, V32, P1940, DOI 10.1111/jdv.15012
   Goyal SN, 2006, PHARMACOL BIOCHEM BE, V85, P369, DOI 10.1016/j.pbb.2006.09.004
   GUPTA MA, 1993, INT J DERMATOL, V32, P188, DOI 10.1111/j.1365-4362.1993.tb02790.x
   HOLSKEN S, 2021, ACTA DERM-VENEREOL, V101, DOI 10.2340/actadv.v101.565
   Jiang YX, 2023, BIODRUGS, V37, P35, DOI 10.1007/s40259-022-00569-z
   Kartha LB, 2014, CLIN CHEM LAB MED, V52, pE123, DOI 10.1515/cclm-2013-0957
   Kerdel FA, 2014, SEMIN CUTAN MED SURG, V33, pS31, DOI 10.12788/j.sder.0066
   Kessler RC, 2006, ARCH GEN PSYCHIAT, V63, P415, DOI 10.1001/archpsyc.63.4.415
   Kokare DM, 2010, NEUROPHARMACOLOGY, V58, P1009, DOI 10.1016/j.neuropharm.2010.01.006
   Komori T, 2016, EUR J DERMATOL, V26, P506, DOI 10.1684/ejd.2016.2832
   Korman AM, 2016, EXPERT OPIN PHARMACO, V17, P147, DOI 10.1517/14656566.2016.1128894
   Kovitwanichkanont T, 2020, MED J AUSTRALIA, V212, P528, DOI 10.5694/mja2.50591
   Lotrich FE, 2011, J RHEUMATOL, V38, P48, DOI 10.3899/jrheum.110903
   Marculescu (Delcea) F, 2022, DERMATO VENEROL, V67, P7
   MArculescu Florentina, 2020, Curr Health Sci J, V46, P203, DOI 10.12865/CHSJ.46.02.16
   Marek-Jozefowicz L, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020669
   Mattei PL, 2014, J EUR ACAD DERMATOL, V28, P333, DOI 10.1111/jdv.12106
   Menter A, 2019, J AM ACAD DERMATOL, V80, P1029, DOI 10.1016/j.jaad.2018.11.057
   Oji V, 2015, CLIN EXP RHEUMATOL, V33, pS14
   Patel N, 2017, AM J CLIN DERMATOL, V18, P613, DOI 10.1007/s40257-017-0279-8
   Saito M, 2010, INT J METH PSYCH RES, V19, P211, DOI 10.1002/mpr.320
   Shear MK, 2001, DEPRESS ANXIETY, V13, P166, DOI 10.1002/da.1033
   Steptoe A, 2007, BRAIN BEHAV IMMUN, V21, P901, DOI 10.1016/j.bbi.2007.03.011
   Stokar E., 2014, Psoriasis Forum, V20, P152
   Strober B, 2018, J AM ACAD DERMATOL, V78, P70, DOI 10.1016/j.jaad.2017.08.051
   Talamonti M, 2021, ACTA DERM-VENEREOL, V101, DOI 10.2340/00015555-3712
   Tian Z, 2019, PSYCHOL HEALTH MED, V24, P269, DOI 10.1080/13548506.2018.1529323
   Tonon AC, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.638981
   Wang YQ, 2022, BEHAV BRAIN RES, V420, DOI 10.1016/j.bbr.2021.113724
   WILLIAMS JBW, 1988, ARCH GEN PSYCHIAT, V45, P742
   Yang A, 2019, ANN DERMATOL VENER, V146, P363, DOI 10.1016/j.annder.2019.03.002
NR 43
TC 1
Z9 1
U1 0
U2 2
PU SOC STIINTE FARMACEUTICE ROMANIA
PI BUCURESTI
PA BUCURESTI, STR TRAIAN VUIA 6, SECT 1, BUCURESTI, 020956, ROMANIA
SN 0014-8237
EI 2065-0019
J9 FARMACIA
JI Farmacia
PD JAN-FEB
PY 2023
VL 71
IS 1
BP 185
EP 193
DI 10.31925/farmacia.2023.1.21
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA N3ME0
UT WOS:001036085900016
OA gold
DA 2025-06-11
ER

PT J
AU Meng, XD
   Han, LH
   Fu, JJ
   Hu, CY
   Lu, Y
AF Meng, Xudong
   Han, Liuhu
   Fu, Jiajing
   Hu, Chengyang
   Lu, Yao
TI Associations between metabolic syndrome and depression, and the
   mediating role of inflammation: Based on the NHANES database
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
ID METAANALYSIS; HEALTH
AB Background: Individuals with metabolic syndrome (MetS) have an increased risk of depressive symptoms, with inflammation hypothesized to mediate ation. This study used data from the National Health and Nutrition Examination Survey (NHANES) (2015-2020) to investigate the relationship between depression and assess the mediating role of inflammatory markers. Methods: This cross-sectional study included 20,520 participants. MetS was defined using the NCEP ATP III criteria. Depressive symptoms were assessed Patient Health Questionnaire-9 (PHQ-9), with scores >= 10 indicating clinical significance. Inflammatory markers evaluated included C-reactive protein blood cell count (WBC), and neutrophil-to-lymphocyte ratio (NLR), among others. Multivariable linear and logistic regression models were applied associations, and mediation analysis was conducted to evaluate the potential mediating effects. Results: Overall, 7.64 % of participants exhibited depressive symptoms. MetS was associated with an increased risk of depression in both females (OR: 1.49, 1.28-1.74) and males (OR: 1.32, 95 % CI: 1.09-1.60) after adjusting for confounders. Among MetS components, central obesity, hypertension, and demonstrated the strongest associations with depression. Inflammatory markers mediated 26.79 % of the MetS-depression relationship, with CRP contributing largest proportion (17.24 %). Conclusion: MetS and its components significantly increase the risk of depressive symptoms, with the relationship partially mediated by inflammatory Chronic inflammation may play a critical role in linking MetS to depression, underscoring the importance of integrated management strategies targeting metabolic and mental health.
C1 [Meng, Xudong; Han, Liuhu; Fu, Jiajing; Lu, Yao] Anhui Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Hefei 230022, Peoples R China.
   [Hu, Chengyang] Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hefei 230032, Peoples R China.
   [Lu, Yao] Anhui Med Univ, Affiliated Hosp 1, Ambulatory Surg Ctr, Hefei 230022, Peoples R China.
C3 Anhui Medical University; Anhui Medical University; Anhui Medical
   University
RP Lu, Y (corresponding author), Anhui Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Hefei 230022, Peoples R China.; Hu, CY (corresponding author), Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hefei 230032, Peoples R China.
EM cy.hu@ahmu.edu.cn; luyao@ahmu.edu.cn
FU Natural Science Research Project of Anhui Educational Committee
   [2023AH053320]; Key Research Project of Anhui Provincial Health
   Commission [AHWJ2022a007]; Research Fund of Anhui Institute of
   Translational Medicine [2023zhyx-C42]
FX This study was supported by the Natural Science Research Project of
   Anhui Educational Committee (2023AH053320) , Key Research Project of
   Anhui Provincial Health Commission (AHWJ2022a007) , and Research Fund of
   Anhui Institute of Translational Medicine (2023zhyx-C42) .
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Levis Brooke, 2019, BMJ, V365, pl1476, DOI [10.1136/bmj.l1781, 10.1136/bmj.l1476]
   [Anonymous], 44. World Health Organization. 2024. https://www.who.int/news-room/fact-sheets/detail/ecoli
   Bandarian F, 2021, DIABETES METAB SYND, V15, P831, DOI 10.1016/j.dsx.2021.04.009
   Beurel E, 2020, NEURON, V107, P234, DOI 10.1016/j.neuron.2020.06.002
   Celano CM, 2020, J PSYCHOSOM RES, V139, DOI 10.1016/j.jpsychores.2020.110285
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Gialluisi A, 2021, J AFFECT DISORDERS, V279, P173, DOI 10.1016/j.jad.2020.10.004
   Goldhaber SZ, 2010, J AM COLL CARDIOL, V56, P1, DOI 10.1016/j.jacc.2010.01.057
   Haapakoski R, 2015, BRAIN BEHAV IMMUN, V49, P206, DOI 10.1016/j.bbi.2015.06.001
   Imai K, 2010, PSYCHOL METHODS, V15, P309, DOI 10.1037/a0020761
   Johnson W.A., 2023, J. Am. Coll. Cardiol., V81, P789, DOI [10.1016/j.jacc.2023.04.056, DOI 10.1016/J.JACC.2023.04.056]
   Kiecolt-Glaser JK, 2015, AM J PSYCHIAT, V172, P1075, DOI 10.1176/appi.ajp.2015.15020152
   Li YH, 2023, BMC PLANT BIOL, V23, DOI [10.1186/s12870-022-04014-9, 10.1186/s12889-023-15740-6, 10.1186/s12889-023-16012-z, 10.1186/s12906-023-04105-6, 10.1186/s12870-023-04353-1]
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Milaneschi Y, 2019, MOL PSYCHIATR, V24, P18, DOI 10.1038/s41380-018-0017-5
   Miller AH, 2016, NAT REV IMMUNOL, V16, P22, DOI 10.1038/nri.2015.5
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Penninx BWJH, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-129
   Pulkki-Råback L, 2009, HEALTH PSYCHOL, V28, P108, DOI 10.1037/a0012646
   Rauschenberg C, 2021, EUR PSYCHIAT, V64, DOI 10.1192/j.eurpsy.2021.17
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Solomon BJ, 2023, LANCET RESP MED, V11, P354, DOI 10.1016/S2213-2600(22)00437-4
   Ullmann U., 2023, Nat. Metab., V5, P215, DOI [10.1038/s42255-022-00674-5, DOI 10.1038/S42255-022-00674-5]
   Vogelzangs N, 2014, NEUROPSYCHOPHARMACOL, V39, P1624, DOI 10.1038/npp.2014.9
   Yaffe K, 2007, J AM GERIATR SOC, V55, P758, DOI 10.1111/j.1532-5415.2007.01139.x
   Yang YF, 2022, J AFFECT DISORDERS, V307, P11, DOI 10.1016/j.jad.2022.03.061
   Yi H, 2024, SCI REP-UK, V14, DOI 10.1038/s41598-024-63058-z
   Zavlis O, 2022, PSYCHOL MED, V52, P3825, DOI 10.1017/S0033291721000635
NR 29
TC 1
Z9 1
U1 27
U2 27
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD APR 15
PY 2025
VL 375
BP 214
EP 221
DI 10.1016/j.jad.2025.01.108
EA JAN 2025
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA X0F7O
UT WOS:001422222500001
PM 39862983
DA 2025-06-11
ER

PT J
AU Katsarou, AL
   Triposkiadis, F
   Panagiotakos, D
AF Katsarou, Alexia L.
   Triposkiadis, Filippos
   Panagiotakos, Demosthenes
TI Perceived Stress and Vascular Disease: Where Are We Now?
SO ANGIOLOGY
LA English
DT Review
DE acute coronary symptoms; coronary heart disease; cardiovascular disease;
   perceived stress; stress perception
ID CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION;
   PSYCHOLOGICAL STRESS; METABOLIC SYNDROME; RISK-FACTORS; PSYCHOSOCIAL
   FACTORS; 52 COUNTRIES; MORTALITY; MEN
AB Apart from traditional risk factors, psychosocial characteristics are increasingly considered as potential predictors of cardiovascular disease (CVD). The concept of stress is relevant when discussing the relationship between psychosocial factors and CVD. Among stress types and definitions (ie, marital stress, work stress), perceived stress presents a global and comprehensive stress construct and is based on the concept that individuals actively interact with their environment, appraising potentially threatening or challenging events in the light of available coping resources. However, the role of perceived stress in CVD incidence has not yet been completely elucidated. Thus, we evaluate perceived stress as a CVD risk factor by reviewing the literature. We also discuss the relationship between negative affect and CVD development.
C1 [Katsarou, Alexia L.; Triposkiadis, Filippos] Univ Thessaly, Dept Cardiol, Sch Med, Larisa 41222, Greece.
   [Panagiotakos, Demosthenes] Univ Athens, Grp Biostat Epidemiol & Res Methods, Dept Nutr & Dietet, Athens, Greece.
C3 University of Thessaly; National & Kapodistrian University of Athens
RP Katsarou, AL (corresponding author), Univ Thessaly, Dept Cardiol, Sch Med, 6 Giannitsioti St, Larisa 41222, Greece.
EM katsaroualexia@gmail.com
RI Panagiotakos, Demosthenes/K-8294-2019
CR Agewall S, 2012, ANGIOLOGY, V63, P17, DOI 10.1177/0003319711407060
   Anagnostis P, 2009, J CLIN ENDOCR METAB, V94, P2692, DOI 10.1210/jc.2009-0370
   Arveiler D, 2005, EUR J CARDIOV PREV R, V12, P209, DOI 10.1097/00149831-200506000-00004
   Athyros VG, 2004, CURR MED RES OPIN, V20, P1691, DOI 10.1185/030079904X5599
   Bekkouche N.S., 2011, HDB STRESS SCI BIOL, P385
   Cannon W., 1932, American Journal of the Medical Sciences, V184, P864, DOI [DOI 10.1054/MEHY.1997.0679, DOI 10.1097/00000441-193212000-00028]
   Chandola T, 2008, EUR HEART J, V29, P640, DOI 10.1093/eurheartj/ehm584
   Charmandari E, 2005, ANNU REV PHYSIOL, V67, P259, DOI 10.1146/annurev.physiol.67.040403.120816
   Chida Y, 2009, J AM COLL CARDIOL, V53, P936, DOI 10.1016/j.jacc.2008.11.044
   Chrousos GP, 2009, NAT REV ENDOCRINOL, V5, P374, DOI 10.1038/nrendo.2009.106
   CHROUSOS GP, 1992, JAMA-J AM MED ASSOC, V267, P1244, DOI 10.1001/jama.267.9.1244
   Clark Cari Jo, 2012, Front Psychiatry, V3, P5, DOI 10.3389/fpsyt.2012.00005
   COHEN S, 1992, SER CLIN C, P109
   COHEN S, 1986, J PERS SOC PSYCHOL, V50, P963, DOI 10.1037/0022-3514.50.5.963
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Davidson KW, 2010, EUR HEART J, V31, P1065, DOI 10.1093/eurheartj/ehp603
   Delahaij R, 2010, PERS INDIV DIFFER, V49, P386, DOI 10.1016/j.paid.2010.04.002
   Detre KM, 1993, CARDIOVASCULAR HLTH, P99
   Dimsdale JE, 2008, J AM COLL CARDIOL, V51, P1237, DOI 10.1016/j.jacc.2007.12.024
   Goldstein DS, 2008, ANN NY ACAD SCI, V1148, P223, DOI 10.1196/annals.1410.061
   Hemingway H, 1999, BMJ-BRIT MED J, V318, P1460, DOI 10.1136/bmj.318.7196.1460
   Hu FB, 2002, DIABETES CARE, V25, P1129, DOI 10.2337/diacare.25.7.1129
   Iso H, 2002, CIRCULATION, V106, P1229, DOI 10.1161/01.CIR.0000028145.58654.41
   Kornitzer M, 2006, EUR J CARDIOV PREV R, V13, P695, DOI 10.1097/01.hjr.0000221865.19415.e9
   Krishnan V, 2008, NATURE, V455, P894, DOI 10.1038/nature07455
   Kyrou I, 2006, ANN NY ACAD SCI, V1083, P77, DOI 10.1196/annals.1367.008
   Lazarus R. S., 1984, STRESS APPRAISAL COP, DOI DOI 10.1002/PER.2410010304
   Lazarus RS., 1977, Human Behavior and Environment: Advances in Theory and Research, V2, P89, DOI [DOI 10.1007/978-1-4684-0808-9_3, 10.1007/978-1-4684-0808-93, DOI 10.1007/978-1-4684-0808-93]
   Littman AJ, 2006, EPIDEMIOLOGY, V17, P398, DOI 10.1097/01.ede.0000219721.89552.51
   Macleod J, 2002, BMJ-BRIT MED J, V324, P1247, DOI 10.1136/bmj.324.7348.1247
   Matthews KA, 2004, CIRCULATION, V109, P66, DOI 10.1161/01.CIR.0000105766.33142.13
   Miller GE, 2007, PSYCHOL BULL, V133, P25, DOI 10.1037/0033-2909.133.1.25
   Nielsen NR, 2008, AM J EPIDEMIOL, V168, P481, DOI 10.1093/aje/kwn157
   Nielsen NR, 2006, EPIDEMIOLOGY, V17, P391, DOI 10.1097/01.ede.0000220556.86419.76
   Panagiotakos DB, 2009, HELL J CARDIOL, V50, P388
   Papathanasiou AL, 2004, ANGIOLOGY, V55, P187, DOI 10.1177/000331970405500211
   Pearson TA, 2002, CIRCULATION, V106, P388, DOI 10.1161/01.CIR.0000020190.45892.75
   Rod NH, 2009, J INTERN MED, V266, P467, DOI 10.1111/j.1365-2796.2009.02124.x
   Roest AM, 2010, J AM COLL CARDIOL, V56, P38, DOI 10.1016/j.jacc.2010.03.034
   ROSENGREN A, 1991, AM J CARDIOL, V68, P1171, DOI 10.1016/0002-9149(91)90189-R
   Rosengren A, 2004, LANCET, V364, P953, DOI 10.1016/S0140-6736(04)17019-0
   Shen BJ, 2008, J AM COLL CARDIOL, V51, P113, DOI 10.1016/j.jacc.2007.09.033
   Strike PC, 2004, PROG CARDIOVASC DIS, V46, P337, DOI 10.1016/j.pcad.2003.09.001
   Strodl E, 2003, INT J BEHAV MED, V10, P205, DOI 10.1207/S15327558IJBM1003_02
   Wilson PWF, 2005, CIRCULATION, V112, P3066, DOI 10.1161/CIRCULATIONAHA.105.539528
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
NR 46
TC 22
Z9 26
U1 7
U2 59
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD OCT
PY 2013
VL 64
IS 7
BP 529
EP 534
DI 10.1177/0003319712458963
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA 208MP
UT WOS:000323683500009
PM 22969163
DA 2025-06-11
ER

PT J
AU Grover, S
   Nebhinani, N
   Chakrabarti, S
   Avasthi, A
AF Grover, Sandeep
   Nebhinani, Naresh
   Chakrabarti, Subho
   Avasthi, Ajit
TI Prevalence of metabolic syndrome among patients with depressive disorder
   admitted to a psychiatric inpatient unit: A comparison with healthy
   controls
SO ASIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Metabolic syndrome; Metabolic abnormalities; Depression; Healthy
   controls; India
ID MAJOR DEPRESSION; MENTAL-ILLNESS; YOUNG-ADULTS; SYMPTOMS; ANXIETY;
   OBESITY; RISK; ASSOCIATION; MORTALITY; CARE
AB Objective: This study aimed to compare the prevalence of metabolic syndrome (MS) among inpatients with depressive disorders and matched healthy controls.
   Method: One hundred fifty eight patients with depressive disorders and 52 age and gender matched healthy controls were assessed for the prevalence of MS using Common Criteria for MS.
   Results: Prevalence of Metabolic syndrome among inpatients with depressive disorders was 44.3%, which was significantly higher than the healthy control group (17.3%). Increased waist circumference was the most common abnormality in both the groups. Prevalence of MS among patients with recurrent depression disorder (60.3%) was almost double that seen among those with first episode depression (32.6%). Compared to healthy controls, significantly greater proportion of patients with depressive disorders had increased blood pressure, abnormal fasting blood sugar, and HDL levels. Besides the prevalence of MS in 44.3% of patients with depressive disorders, another 46% of patients fulfilled one or two criteria of MS. Significant predictors of MS were being married, obese, greater age, higher weight, higher body mass index, and multiple episodes of depression.
   Conclusions: Nearly two-fifth of depressed patients have MS and another two-fifth of patients had one or two abnormalities in the MS criteria. The prevalence of MS among patients with depressive disorders is significantly higher than the healthy controls. Hence, patients with depressive disorders should be regularly evaluated for the presence of MS and other cardiovascular risk factors and appropriate management strategies must be instituted at the earliest. (C) 2017 Elsevier B.V. All rights reserved.
C1 [Grover, Sandeep; Chakrabarti, Subho; Avasthi, Ajit] Post Grad Inst Med Educ & Res, Dept Psychiat, Chandigarh 160012, India.
   [Nebhinani, Naresh] AIIMS, Dept Psychiat, Jodhpur, Rajasthan, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh; All India Institute of Medical Sciences (AIIMS) Jodhpur
RP Grover, S (corresponding author), Post Grad Inst Med Educ & Res, Dept Psychiat, Chandigarh 160012, India.
EM drsandeepg2002@yahoo.com
OI Grover, Sandeep/0000-0002-2714-2055; chakrabarti,
   subho/0000-0001-6023-2194
CR Agarwal A, 2016, INDIAN J PSYCHIAT, V58, P281, DOI 10.4103/0019-5545.192021
   Aggarwal M., 2012, J MENTAL HLTH HUM BE, V17, P15
   Ahola AJ, 2010, ANN MED, V42, P495, DOI 10.3109/07853890.2010.503660
   Akbaraly TN, 2011, DIABETES CARE, V34, P904, DOI 10.2337/dc10-1644
   Akbaraly TN, 2009, DIABETES CARE, V32, P499, DOI 10.2337/dc08-1358
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Almeida OP, 2009, AM J GERIAT PSYCHIAT, V17, P889, DOI 10.1097/JGP.0b013e3181b047e3
   [Anonymous], 1992, The ICD-10 classification of mental and behavioural disorders: Clinical descriptions and diagnostic guidelines
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   East C, 2010, METAB SYNDR RELAT D, V8, P451, DOI 10.1089/met.2010.0017
   Ferrari AJ, 2013, PLOS MED, V10, DOI 10.1371/journal.pmed.1001547
   Foley DL, 2010, TWIN RES HUM GENET, V13, P347, DOI 10.1375/twin.13.4.347
   Gil Katarzyna, 2006, Kardiol Pol, V64, P464
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Grover Sandeep, 2013, Indian J Psychol Med, V35, P167, DOI 10.4103/0253-7176.116247
   Heiskanen TH, 2006, J CLIN PSYCHIAT, V67, P1422, DOI 10.4088/JCP.v67n0913
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Hung CI, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/1471-244X-14-185
   Igna CV, 2008, PSYCHOSOM MED, V70, P960, DOI 10.1097/PSY.0b013e318189a942
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Kahl KG, 2011, EUR ARCH PSYCHIAT CL
   Kimura Yasumi, 2011, Environmental Health and Preventive Medicine, V16, P363, DOI 10.1007/s12199-011-0206-1
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178, DOI 10.4088/JCP.v69n0202
   Lawrence D, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f2539
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Mattoo SK, 2010, INDIAN J MED RES, V131, P46
   Miettola J, 2008, SCAND J PRIM HEALTH, V26, P203, DOI 10.1080/02813430802117624
   Mitchell AJ, 2012, BRIT J PSYCHIAT, V201, P435, DOI 10.1192/bjp.bp.111.094532
   Muhtz C, 2009, PSYCHONEUROENDOCRINO, V34, P1004, DOI 10.1016/j.psyneuen.2009.01.016
   Osborn DPJ, 2007, ARCH GEN PSYCHIAT, V64, P242, DOI 10.1001/archpsyc.64.2.242
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pulkki-Råback L, 2009, HEALTH PSYCHOL, V28, P108, DOI 10.1037/a0012646
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Rathi A., 2013, DELHI PSYCHIAT J, V16, P7
   Richter N, 2010, EUR ARCH PSY CLIN N, V260, P41, DOI 10.1007/s00406-009-0013-5
   Seppälä J, 2012, J AFFECT DISORDERS, V136, P543, DOI 10.1016/j.jad.2011.10.032
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Takeuchi T, 2009, DIABETES METAB, V35, P32, DOI 10.1016/j.diabet.2008.06.006
   Toker S, 2008, DEPRESS ANXIETY, V25, P661, DOI 10.1002/da.20379
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vanhala M, 2009, ACTA PSYCHIAT SCAND, V119, P137, DOI 10.1111/j.1600-0447.2008.01283.x
   Vogelzangs N, 2007, PSYCHONEUROENDOCRINO, V32, P151, DOI 10.1016/j.psyneuen.2006.11.009
NR 47
TC 13
Z9 13
U1 1
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1876-2018
EI 1876-2026
J9 ASIAN J PSYCHIATR
JI Asian J. Psychiatr.
PD JUN
PY 2017
VL 27
BP 139
EP 144
DI 10.1016/j.ajp.2017.02.030
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA FB3GS
UT WOS:000406031500026
PM 28558888
DA 2025-06-11
ER

PT J
AU Deschênes, SS
   Kivimaki, M
   Schmitz, N
AF Deschenes, Sonya S.
   Kivimaki, Mika
   Schmitz, Norbert
TI Adverse Childhood Experiences and the Risk of Coronary Heart Disease in
   Adulthood: Examining Potential Psychological, Biological, and Behavioral
   Mediators in the Whitehall II Cohort Study
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE adverse childhood experiences; coronary heart disease; health behaviors;
   mental health; metabolic dysregulations
ID BRITISH CIVIL-SERVANTS; PHYSICAL-ACTIVITY; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; FOLLOW-UP; SLEEP; METAANALYSIS; DEPRESSION;
   DISORDERS; ANXIETY
AB Background
   This study investigated potential psycho-bio-behavioral mediators of the association between adverse childhood experiences (ACEs) and the risk of coronary heart disease (CHD) in adulthood.
   Methods and Results
   Participants were 5610 British civil servants (mean age, 55.5; 28% women) from the Whitehall II cohort study without CHD at baseline in 1997 to 1999 (wave 5) when retrospective data on the number of ACEs were collected via questionnaire (range, 0-8). Potential mediators assessed at wave 5 included depression and anxiety symptoms, health behaviors (smoking, alcohol dependence, sleep, and physical activity), and cardiometabolic dysregulations. New diagnoses of CHD (myocardial infarction, definite angina, coronary artery bypass grafting, or percutaneous transluminal coronary angioplasty) were assessed from wave 6 (2001) to wave 11 (2012-2013). Logistic regressions examined associations between ACEs, potential mediators, and CHD during the follow-up period. Natural indirect effects were examined using mediation analysis. A total of 566 (10.1%) participants developed CHD during the follow-up period. ACEs were associated with an increased likelihood of CHD (odds ratio per ACE, 1.09; 95% CI, 1.00-1.19). Controlling for age and sex, mediation analyses revealed an indirect effect of depression symptoms (natural indirect effects, 1.05; 95% CI, 1.03-1.07), anxiety symptoms (natural indirect effects, 1.12; 95% CI, 1.10-1.15), and a greater number of cardiometabolic dysregulations (natural indirect effects, 1.02; 95% CI, 1.01-1.03) in the association between ACEs and incident CHD. Behavioral factors were not statistically significant mediators.
   Conclusions
   Depression symptoms, anxiety symptoms, and cardiometabolic dysregulations partially mediated the association between ACEs and CHD. Regular screening and treatment of symptoms of psychological disorders and cardiometabolic dysregulations may help mitigate the long-term health burden of ACEs.
C1 [Deschenes, Sonya S.] Univ Coll Dublin, Sch Psychol, Dublin, Ireland.
   [Kivimaki, Mika] UCL, Dept Epidemiol & Publ Hlth, London, England.
   [Schmitz, Norbert] McGill Univ, Dept Psychiat, Montreal, PQ, Canada.
   [Schmitz, Norbert] Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada.
   [Schmitz, Norbert] Univ Tubingen, Med Univ Hosp Tubingen, Dept Populat Based Med, Tubingen, Germany.
C3 University College Dublin; University of London; University College
   London; McGill University; Eberhard Karls University of Tubingen;
   Eberhard Karls University Hospital
RP Deschênes, SS (corresponding author), Univ Coll Dublin, UCD Sch Psychol, Newman Bldg,Stillorgan Rd, Dublin 4, Ireland.
EM sonya.deschenes@ucd.ie
RI Deschenes, Sonya/G-6341-2017; Kivimaki, Mika/B-3607-2012
OI Kivimaki, Mika/0000-0002-4699-5627; Deschenes, Sonya/0000-0002-9258-0895
FU Medical Research Council [K013351, R024227]; British Heart Foundation
   [RG/13/2/30098]; National Institute on Aging (National Institutes of
   Health) [R01AG056477, R01AG062553]; UK Medical Research Council
   [K013351, R024227, S011676]; NordForsk [75021]; Academy of Finland
   [311492]; Helsinki Institute of Life Science [H970]
FX The Whitehall II study is supported by grants from the Medical Research
   Council (K013351, R024227), the British Heart Foundation
   (RG/13/2/30098), and the National Institute on Aging (National
   Institutes of Health, R01AG056477, R01AG062553). Dr Kivimaki was
   supported by the UK Medical Research Council (K013351, R024227,
   S011676), the National Institute on Aging (National Institutes of
   Health, R01AG056477, R01AG062553), NordForsk (75021), the Academy of
   Finland (311492), and Helsinki Institute of Life Science (H970).
CR Alberti K., 2009, CLIN EXP RHEUMATOL CLIN EXP RHEUMATOL, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   [Anonymous], 2013, PARAMED: Stata module to perform causal mediation analysis using parametric regression models Internet
   [Anonymous], 2021, J AM HEART ASSOC, V10, DOI [10.1161/JAHA.120.019013, DOI 10.1161/JAHA.120.019013]
   Ayas NT, 2003, ARCH INTERN MED, V163, P205, DOI 10.1001/archinte.163.2.205
   Barbaresko J, 2018, AM J PREV MED, V55, P555, DOI 10.1016/j.amepre.2018.04.046
   Baumeister D, 2016, MOL PSYCHIATR, V21, P642, DOI 10.1038/mp.2015.67
   Bellis MA, 2014, J PUBLIC HEALTH-UK, V36, P81, DOI 10.1093/pubmed/fdt038
   Berens AE, 2017, BMC MED, V15, DOI 10.1186/s12916-017-0895-4
   Bertisch SM, 2018, SLEEP, V41, DOI 10.1093/sleep/zsy047
   Bolin JH, 2014, J EDUC MEAS, V51, P335, DOI 10.1111/jedm.12050
   Chapman DP, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-3
   Chapman DP, 2011, SLEEP MED, V12, P773, DOI 10.1016/j.sleep.2011.03.013
   Chapman DP, 2004, J AFFECT DISORDERS, V82, P217, DOI 10.1016/j.jad.2003.12.013
   Chiha M, 2012, INT J HYPERTENS, V2012, DOI 10.1155/2012/697240
   Cronholm PF, 2015, AM J PREV MED, V49, P354, DOI 10.1016/j.amepre.2015.02.001
   Danese A, 2012, PHYSIOL BEHAV, V106, P29, DOI 10.1016/j.physbeh.2011.08.019
   De Venter M, 2013, Tijdschr Psychiatr, V55, P259
   Deschênes SS, 2020, PSYCHOSOM MED, V82, P296, DOI 10.1097/PSY.0000000000000790
   Deschênes SS, 2018, DIABETES CARE, V41, P2120, DOI 10.2337/dc18-0932
   Duffy KA, 2018, ANN NY ACAD SCI, V1428, P151, DOI 10.1111/nyas.13928
   Emdin CA, 2016, AM J CARDIOL, V118, P511, DOI 10.1016/j.amjcard.2016.05.041
   EWING JA, 1984, JAMA-J AM MED ASSOC, V252, P1905, DOI 10.1001/jama.252.14.1905
   Felitti VJ, 1998, AM J PREV MED, V14, P245, DOI 10.1016/S0749-3797(98)00017-8
   Gan Y, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/s12888-014-0371-z
   GOLDBERG DP, 1972, DETECTION PSYCHIATRI
   Hackett RA, 2016, CURR CARDIOL REP, V18, DOI 10.1007/s11886-016-0771-4
   Hamer M, 2013, OBESITY, V21, pE755, DOI 10.1002/oby.20446
   Hamer M, 2012, CIRCULATION, V126, P928, DOI 10.1161/CIRCULATIONAHA.112.103879
   Hughes K, 2017, LANCET PUBLIC HEALTH, V2, pE356, DOI 10.1016/S2468-2667(17)30118-4
   Jakubowski KP, 2018, HEALTH PSYCHOL, V37, P701, DOI 10.1037/hea0000637
   Javaheri S, 2017, CHEST, V152, P435, DOI 10.1016/j.chest.2017.01.026
   Kalmakis KA, 2015, J AM ASSOC NURSE PRA, V27, P457, DOI 10.1002/2327-6924.12215
   Kivimäki M, 2018, NAT REV CARDIOL, V15, P215, DOI 10.1038/nrcardio.2017.189
   Komulainen K, 2019, AM J PREV MED, V57, pE195, DOI 10.1016/j.amepre.2019.08.018
   Lee C, 2014, SOC SCI MED, V105, P122, DOI 10.1016/j.socscimed.2014.01.017
   Lee IM, 2012, LANCET, V380, P219, DOI 10.1016/S0140-6736(12)61031-9
   Marmot M, 2005, INT J EPIDEMIOL, V34, P251, DOI 10.1093/ije/dyh372
   MARMOT MG, 1991, LANCET, V337, P1387, DOI 10.1016/0140-6736(91)93068-K
   MAYFIELD D, 1974, AM J PSYCHIAT, V131, P1121
   McEwen Bruce S, 2017, Chronic Stress (Thousand Oaks), V1, DOI 10.1177/2470547017692328
   McEwen BS, 2003, BIOL PSYCHIAT, V54, P200, DOI 10.1016/S0006-3223(03)00177-X
   Miller GE, 2011, PSYCHOL BULL, V137, P959, DOI 10.1037/a0024768
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Organization WH, 2018, GLOBAL HLTH EST 2016
   RICHARDSON MT, 1994, J CLIN EPIDEMIOL, V47, P271, DOI 10.1016/0895-4356(94)90008-6
   Rotella F, 2013, J CLIN PSYCHIAT, V74, P32, DOI 10.4088/JCP.12r07922
   Sabia S, 2018, BMJ-BRIT MED J, V362, DOI 10.1136/bmj.k2927
   Sabia S, 2017, BMJ-BRIT MED J, V357, DOI 10.1136/bmj.j2709
   Sanchis-Gomar F, 2016, ANN TRANSL MED, V4, DOI 10.21037/atm.2016.06.33
   Sareen J, 2013, PSYCHOL MED, V43, P73, DOI 10.1017/S003329171200102X
   STANSFELD SA, 1992, PSYCHOL MED, V22, P739, DOI 10.1017/S0033291700038186
   Su S, 2015, CURR CARDIOL REP, V17, DOI 10.1007/s11886-015-0645-1
   Suglia SF, 2018, CIRCULATION, V137, pE15, DOI 10.1161/CIR.0000000000000536
   Turner RJ, 2016, SOC SCI MED, V156, P114, DOI 10.1016/j.socscimed.2016.02.026
   Valeri L, 2013, PSYCHOL METHODS, V18, P137, DOI 10.1037/a0031034
   VanderWeele TJ, 2016, INT J EPIDEMIOL, V45, P1904, DOI 10.1093/ije/dyw277
   VanderWeele TJ, 2013, EPIDEMIOLOGY, V24, P175, DOI 10.1097/EDE.0b013e3182781410
   VanderWeele TJ, 2011, EPIDEMIOLOGY, V22, P582, DOI 10.1097/EDE.0b013e31821db37e
   Wade TJ, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2019-030339
   Waehrer GM, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0226134
   Watson NF, 2015, SLEEP, V38, P843, DOI 10.5665/sleep.4716
   Wegman HL, 2009, PSYCHOSOM MED, V71, P805, DOI 10.1097/PSY.0b013e3181bb2b46
   WHO, 2010, SCREENING DONATED BLOOD FOR TRANSFUSION: TRANSMISSIBLE INFECTIONS, P1
   Wilson PWF, 2005, CIRCULATION, V112, P3066, DOI 10.1161/CIRCULATIONAHA.105.539528
NR 64
TC 34
Z9 36
U1 2
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD MAY 18
PY 2021
VL 10
IS 10
AR e019013
DI 10.1161/JAHA.120.019013
PG 12
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA SD5SR
UT WOS:000651436300010
PM 33938232
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Brillante, DG
   O'Sullivan, AJ
   Brillante, RE
   Howes, LG
AF Brillante, Divina Gracilla
   O'Sullivan, Anthony John
   Brillante, Ruby Esmeralda
   Howes, Laurence Guy
TI Effects of cardiovascular angiotensin II type 1 receptor blockade on
   nitric oxide synthase inhibition in patients with insulin resistance
   syndrome
SO BLOOD PRESSURE
LA English
DT Article
DE Arterial stiffness; AT(1) receptor; digital photoplethysmography;
   haemodynamics; insulin resistance syndrome; telmisartan
ID ENDOTHELIUM-DEPENDENT VASODILATION; ARTERIAL STIFFNESS; METABOLIC
   SYNDROME; DIABETES-MELLITUS; OXIDATIVE STRESS; BLOOD-PRESSURE;
   EXPRESSION; CORONARY; GLUCOSE; NO
AB Background. There is evidence that in the early stages of type 11 diabetes, the cardiovascular system compensates by increasing endothelial nitric oxide synthase (e-NOS) expression. In the advanced stages of disease, e-NOS is diminished, and is associated with endothelial dysfunction. Angiotensin H, acting via the angiotensin II type I (AT(1)) receptor, is central to the development of endothelial dysfunction. The effect of AT(1) receptor blockade on NOS expression and activity in humans with early insulin resistance syndrome (INSR) has not been previously investigated. Eight subjects with INSR participated in a randomized, double-blind, placebo-controlled, crossover study. Subjects were randomized to receive telmisartan or placebo (I month of each) in a two-period crossover study with a 1-week washout period in between. The arterial stiffness and haemodynamic response to intravenous L-nitro-monomethyl arginine (L-NMMA 3 mg/kg) was assessed at baseline and at the end of each treatment phase. SI (Stiffness index, a measure of large artery stiffness) and RI (Reflection index, small-to medium-sized arterial stiffness) were measured using digital photoplethysmography. Haemodynamic parameters [Heart rate (HR), Systolic blood pressure (SBP), Diastolic BP (DBP) and Systemic vascular resistance index (SVRI)] were measured non-invasively using trans-thoracic bioimpedance. Results. Telmisartan significantly reduced baseline SI, SBP, DBP and SVRI. Infusion of L-NMMA produced a significant increase in RI and a significant reduction in HR during placebo therapy. Telmisartan therapy attenuated these responses. Conclusion. Telmisartan therapy reduced NOS activity and/or expression in these subjects, possibly because of improved vascular function arising from AT(1) receptor blockade.
C1 [Howes, Laurence Guy] Griffith & Bond Univ, Sch Med, Dept Cardiol, Gold Coast Hosp, Southport, Qld 4215, Australia.
   [Brillante, Divina Gracilla; O'Sullivan, Anthony John] Univ New S Wales, Dept Med, St George Clin Sch, Kogarah, NSW, Australia.
   [Brillante, Ruby Esmeralda] Concord Hosp, Dept Resp & Sleep Med, Sydney, NSW, Australia.
C3 Griffith University; Griffith University - Gold Coast Campus; Gold Coast
   University Hospital; Bond University; University of New South Wales
   Sydney; Concord Repatriation General Hospital
RP Howes, LG (corresponding author), Griffith & Bond Univ, Sch Med, Dept Cardiol, Gold Coast Hosp, Nerang St, Southport, Qld 4215, Australia.
EM Laurie_Howes@health.qld.gov.au
RI Howes, Laurence/M-4551-2019
OI Howes, Laurence/0000-0002-1507-8260
FU Royal Australasian College of Physicians Research Foundation; National
   Health and Medical Research Council (NHMRC),Australia
FX Dr Brillante received a scholarship from the Royal Australasian College
   of Physicians Research Foundation and the National Health and Medical
   Research Council (NH&MRC),Australia. Boehringer-Ingelheim provided the
   active Telmisartan tablets and donated $5000 to the University of New
   South Wales to aid in the purchase of consumables for this project, and
   were not involved in the design, conduct and writing up of the study.
CR Al Suwaidi J, 2000, CIRCULATION, V101, P948, DOI 10.1161/01.CIR.101.9.948
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Batenburg WW, 2004, CIRCULATION, V109, P2296, DOI 10.1161/01.CIR.0000128696.12245.57
   Brillante DG, 2008, DIABETES OBES METAB, V10, P143, DOI 10.1111/j.1463-1326.2006.00678.x
   Brillante DG, 2005, J RENIN-ANGIO-ALDO S, V6, P102, DOI 10.3317/jraas.2005.007
   Brillante DG, 2008, CLIN SCI, V114, P139, DOI 10.1042/CS20070132
   Chowienczyk PJ, 1999, J AM COLL CARDIOL, V34, P2007, DOI 10.1016/S0735-1097(99)00441-6
   CHRISTIANSEN JS, 1988, SCAND J CLIN LAB INV, V48, P451, DOI 10.3109/00365518809085756
   Clarkson P, 1996, J AM COLL CARDIOL, V28, P573, DOI 10.1016/0735-1097(96)82380-1
   Cosentino F, 1997, CIRCULATION, V96, P25
   Darko D, 2002, CLIN SCI, V103, P339, DOI 10.1042/cs1030339
   DOHA A, CANPRINT COMMUNICATI, P141
   Drummond GR, 2000, CIRC RES, V86, P347, DOI 10.1161/01.RES.86.3.347
   Förstermann U, 2006, CIRCULATION, V113, P1708, DOI 10.1161/CIRCULATIONAHA.105.602532
   Goetz RM, 1999, CLIN SCI, V97, P165, DOI 10.1042/CS19990003
   Gopaul NK, 2001, DIABETOLOGIA, V44, P706, DOI 10.1007/s001250051679
   Greenberg B H, 2000, Congest Heart Fail, V6, P74, DOI 10.1111/j.1527-5299.2000.80140.x
   HAN X, 1994, J PHYSIOL-LONDON, V476, P309, DOI 10.1113/jphysiol.1994.sp020132
   Han XQ, 1997, CAN J CARDIOL, V13, P1191
   HELDLAND A, 1989, DIABETES KIDNEY CONT
   Higashi T, 2000, J CARDIOVASC PHARM, V35, P564, DOI 10.1097/00005344-200004000-00009
   Hink U, 2001, CIRC RES, V88, pE14
   HIROOKA Y, 1994, J AM COLL CARDIOL, V24, P948, DOI 10.1016/0735-1097(94)90854-0
   Howes LG, 2006, DIABETES OBES METAB, V8, P8, DOI 10.1111/j.1463-1326.2005.00469.x
   Kaesemeyer WH, 1999, J AM COLL CARDIOL, V33, P234, DOI 10.1016/S0735-1097(98)00514-2
   Kano H, 1999, BIOCHEM BIOPH RES CO, V259, P414, DOI 10.1006/bbrc.1999.0799
   Kuvin JT, 2001, J AM COLL CARDIOL, V38, P1843, DOI 10.1016/S0735-1097(01)01657-6
   Laucevicius A., 2002, Seminars in Cardiology, V8, P87
   Li HG, 2002, NITRIC OXIDE-BIOL CH, V7, P149, DOI 10.1016/S1089-8603(02)00111-8
   Lieberman EH, 1996, AM J CARDIOL, V78, P1210, DOI 10.1016/S0002-9149(96)00597-8
   Linz W, 2000, HYPERTENSION, V35, P908, DOI 10.1161/01.HYP.35.4.908
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   ODDIS CV, 1994, BIOCHEM BIOPH RES CO, V205, P992, DOI 10.1006/bbrc.1994.2764
   Stehouwer CDA, 2008, DIABETOLOGIA, V51, P527, DOI 10.1007/s00125-007-0918-3
   Tagawa T, 1997, J CARDIOVASC PHARM, V29, P546, DOI 10.1097/00005344-199704000-00017
   TUCK M, 1988, AM J HYPERTENS, V1, pS384, DOI 10.1093/ajh/1.4.384S
   Weidmann P, 1985, HYPERTENSION 2, V7, p[I133, 133]
   Woodman RJ, 2006, DIABETES RES CLIN PR, V71, P59, DOI 10.1016/j.diabres.2005.05.008
   YUNG GLF, 1999, CHEST, V116
   ZEMEL MB, 1992, AM J PHYSIOL, V262, pE368, DOI 10.1152/ajpendo.1992.262.3.E368
   Zieman SJ, 2005, ARTERIOSCL THROM VAS, V25, P932, DOI 10.1161/01.ATV.0000160548.78317.29
NR 42
TC 2
Z9 2
U1 0
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
EI 1651-1999
J9 BLOOD PRESSURE
JI Blood Pressure
PY 2009
VL 18
IS 3
BP 142
EP 148
DI 10.1080/08037050902982284
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 478FP
UT WOS:000268573500010
PM 19462315
OA Bronze
DA 2025-06-11
ER

PT J
AU Huang, CI
   Lin, LC
   Tien, HC
   Que, J
   Ting, WC
   Chen, PC
   Wu, HM
   Ho, CH
   Wang, JJ
   Wang, RH
   Yang, CC
AF Huang, Chung-I
   Lin, Li-Ching
   Tien, Hung-Cheng
   Que, Jenny
   Ting, Wei Chen
   Chen, Po-Chun
   Wu, Hsin-Min
   Ho, Chung-Han
   Wang, Jhi-Joung
   Wang, Ren-Hong
   Yang, Ching-Chieh
TI Hyperlipidemia and statins use for the risk of new-onset
   anxiety/depression in patients with head and neck cancer: A
   population-based study
SO PLOS ONE
LA English
DT Article
ID QUALITY-OF-LIFE; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; DEPRESSION;
   ANXIETY; INFLAMMATION; METAANALYSIS; MORTALITY; SYMPTOMS
AB Objective
   Anxiety/depression is common among patients with head and neck cancer (HNC), and can negatively affect treatment compliance and outcome. The aim of this study was to assess the association between hyperlipidemia and the risk of new-onset anxiety/depression after the diagnosis of HNC and the influence of administering statins.
   Methods
   A matched longitudinal cohort study of 1632 subjects (408 HNC patients with preexisting hyperlipidemia and 1224 age- and sex-matched HNC patients without hyperlipidemia) was included and analyzed by using data from Taiwan's National Health Insurance Research Database from January 1996 to December 2012. The incidence and hazard ratios (HRs) for the development of new-onset anxiety/depression were examined between the two groups. Cox proportional hazard regression was applied to estimate the relative risks of anxiety/depressive disorders adjusted for potential confounding factors. To estimate the risks of anxiety/depression in different sub-groups, a stratified analysis was also used.
   Results
   HNC patients with preexisting hyperlipidemia had a higher risk for comorbidities such as hypertension, diabetes mellitus, and cardiovascular disease (P <0.001). The incidence rate of anxiety/depression in the HNC patients with preexisting hyperlipidemia was also significantly higher than that among patients without hyperlipidemia (10.78% vs 7.27%, respectively; P = 0.03). A Cox regression model revealed that preexisting hyperlipidemia was an independent risk factor for anxiety/depression (aHR, 1.96; 95% CI, 1.30-2.94). Statins use was protective against anxiety/depression among HNC patients with hyperlipidemia ( aHR, 0.85; 95% CI, 0.46-1.57), especially for individuals older than 65 years and for females.
   Conclusions
   Preexisting hyperlipidemia was associated with increased risk of new-onset anxiety/depression in the HNC patients. Statins use for HNC patients with hyperlipidemia could decrease the risk of anxiety/depression, especially for those older than 65 years and for female patients.
C1 [Huang, Chung-I] E Da Canc Hosp, Dept Radiat Oncol, Kaohsiung, Taiwan.
   [Lin, Li-Ching; Que, Jenny; Ting, Wei Chen; Yang, Ching-Chieh] Chi Mei Med Ctr, Dept Radiat Oncol, Tainan, Taiwan.
   [Tien, Hung-Cheng] Minist Hlth & Welf, Pingtung Hosp, Dept Psychiat, Pingtung, Taiwan.
   [Chen, Po-Chun] Pingtung Christian Hosp, Dept Radiat Oncol, Pingtung, Taiwan.
   [Wu, Hsin-Min] Natl Cheng Kung Univ, Dept Publ Hlth, Coll Med, Natl Cheng Kung Univ Hosp, Tainan, Taiwan.
   [Ho, Chung-Han; Wang, Jhi-Joung] Chi Mei Med Ctr, Dept Med Res, Tainan, Taiwan.
   [Ho, Chung-Han] Chia Nan Univ Pharm & Sci, Dept Pharm, Tainan, Taiwan.
   [Wang, Ren-Hong] Chi Mei Med Ctr, Dept Clin Pathol, Tainan, Taiwan.
   [Wang, Ren-Hong] Chung Hwa Univ Med Technol, Dept Med Lab Sci & Biotechnol, Tainan, Taiwan.
   [Yang, Ching-Chieh] Natl Sun Yat Sen Univ, Inst Biomed Sci, Kaohsiung, Taiwan.
   [Yang, Ching-Chieh] Chia Nan Univ Pharm & Sci, Dept Biotechnol, Tainan, Taiwan.
C3 E-Da Hospital; Chi Mei Hospital; National Cheng Kung University;
   National Cheng Kung University Hospital; Chi Mei Hospital; Chia Nan
   University of Pharmacy & Science; Chi Mei Hospital; Chung Hua
   University; National Sun Yat Sen University; Chia Nan University of
   Pharmacy & Science
RP Yang, CC (corresponding author), Chi Mei Med Ctr, Dept Radiat Oncol, Tainan, Taiwan.; Yang, CC (corresponding author), Natl Sun Yat Sen Univ, Inst Biomed Sci, Kaohsiung, Taiwan.; Yang, CC (corresponding author), Chia Nan Univ Pharm & Sci, Dept Biotechnol, Tainan, Taiwan.
EM cleanclear0905@gmail.com
RI Chen, Chin-Chuan/G-3094-2013; Yang, Ching-Chieh/JXN-6880-2024; Chen,
   PoChun/KIG-7338-2024
OI Ho, Chung-Han/0000-0001-5925-8477
CR Alexopoulos GS, 1997, ARCH GEN PSYCHIAT, V54, P915
   [Anonymous], 2014, ACTA CLIN CROAT, V53, P55, DOI DOI 10.3109/14992027.2013.839886
   Baigent C, 2005, LANCET, V366, P1267, DOI 10.1016/S0140-6736(05)67394-1
   Blum A, 2009, ATHEROSCLEROSIS, V203, P325, DOI 10.1016/j.atherosclerosis.2008.08.022
   Can ÖD, 2012, BEHAV PHARMACOL, V23, P582, DOI 10.1097/FBP.0b013e328356c3f2
   Chan CMH, 2015, PSYCHO-ONCOLOGY, V24, P718, DOI 10.1002/pon.3714
   Chen YJ, 2008, CANCER SCI, V99, P1507, DOI 10.1111/j.1349-7006.2008.00863.x
   Chuang CS, 2014, GEN HOSP PSYCHIAT, V36, P497, DOI 10.1016/j.genhosppsych.2014.05.008
   Cohen M, 2014, PSYCHO-ONCOLOGY, V23, P151, DOI 10.1002/pon.3383
   Curry Andrew, 2015, Diabetes Forecast, V68, P90
   Dortland AKBV, 2010, ACTA PSYCHIAT SCAND, V122, P30, DOI 10.1111/j.1600-0447.2010.01565.x
   Dortland AKBV, 2010, J CLIN PSYCHIAT, V71, P729, DOI 10.4088/JCP.08m04865blu
   Duffy SA, 2007, PSYCHOSOMATICS, V48, P142, DOI 10.1176/appi.psy.48.2.142
   Frampton M, 2001, BRIT J ORAL MAX SURG, V39, P67, DOI 10.1054/bjom.2000.0547
   Hare DL, 2014, EUR HEART J, V35, P1365, DOI 10.1093/eurheartj/eht462
   Ho CH, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2014-005269
   Holland JC, 2003, J CLIN ONCOL, V21, p253S, DOI 10.1200/JCO.2003.09.133
   Johansson R, 2013, PEERJ, V1, DOI 10.7717/peerj.98
   Kawada T, 2015, INT J CARDIOL, V198, P40, DOI 10.1016/j.ijcard.2015.06.141
   Levitt SH, 2003, INT J RADIAT ONCOL, V55, P645, DOI 10.1016/S0360-3016(02)04076-2
   Lu JFR, 2011, HEALTH ECON POLICY L, V6, P85, DOI 10.1017/S1744133109990351
   Maruyama K, 2005, NEW ENGL J MED, V352, P146, DOI 10.1056/NEJMoa040907
   McFarland AJ, 2014, INT J MOL SCI, V15, P20607, DOI 10.3390/ijms151120607
   Nugent NR, 2011, PSYCHOPHARMACOLOGY, V214, P175, DOI 10.1007/s00213-010-2151-x
   O'Neil A, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-154
   Olson MB, 2008, J WOMENS HEALTH, V17, P187, DOI 10.1089/jwh.2007.0379
   Owonikoko TK, 2013, ONCOLOGIST, V18, P600, DOI 10.1634/theoncologist.2012-0480
   Pranjic Nurka, 2016, Mater Sociomed, V28, P12, DOI 10.5455/msm.2016.28.12-16
   Tietge UJF, 2014, CURR OPIN LIPIDOL, V25, P94, DOI 10.1097/MOL.0000000000000051
   While A, 2012, EUR J CARDIOVASC NUR, V11, P85, DOI 10.1016/j.ejcnurse.2010.08.008
   Wu YS, 2016, NEUROPSYCH DIS TREAT, V12, P1029, DOI 10.2147/NDT.S103203
   Zeller JL, 2006, JAMA-J AM MED ASSOC, V296, P1716, DOI 10.1001/jama.296.14.1716
   Zureik M, 1996, BMJ-BRIT MED J, V313, P649, DOI 10.1136/bmj.313.7058.649
NR 33
TC 12
Z9 13
U1 0
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 31
PY 2017
VL 12
IS 3
AR e0174574
DI 10.1371/journal.pone.0174574
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA ER9VK
UT WOS:000399175000019
PM 28362860
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Maes, M
   Zhou, B
   Jirakran, K
   Vasupanrajit, A
   Boonchaya-Anant, P
   Tunvirachaisakul, C
   Tang, XO
   Li, J
   Almulla, AF
AF Maes, Michael
   Zhou, Bo
   Jirakran, Ketsupar
   Vasupanrajit, Asara
   Boonchaya-Anant, Patchaya
   Tunvirachaisakul, Chavit
   Tang, Xiaoou
   Li, Jing
   Almulla, Abbas F.
TI Towards a major methodological shift in depression research by assessing
   continuous scores of recurrence of illness, lifetime and current
   suicidal behaviors and phenome features
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Major depression; Biomarkers; Precision psychiatry; Neuro-immune;
   Inflammation; Oxidative stress
ID DENSITY-LIPOPROTEIN CHOLESTEROL; METABOLIC SYNDROME; RATING-SCALE;
   RESISTANCE; DISORDER; PLASMA
AB Background: The binary major depressive disorder (MDD) diagnosis is inadequate and should never be used in research. Aims: The study's objective is to explicate our novel precision nomothetic strategy for constructing depression models based on adverse childhood experiences (ACEs), lifetime and current phenome, and biomarker (atherogenicity indices) scores. Methods: This study assessed recurrence of illness (ROI: namely recurrence of depressive episodes and suicidal behaviors, SBs), lifetime and current SBs and the phenome of depression, neuroticism, dysthymia, anxiety disorders, and lipid biomarkers including apolipoprotein (Apo)A, ApoB, free cholesterol and cholesteryl esters, triglycerides, high density lipoprotein cholesterol in 67 normal controls and 66 MDD patients. We computed atherogenic and reverse cholesterol transport indices. Results: We were able to extract one factor from a) the lifetime phenome of depression comprising ROI, and traits such as neuroticism, dysthymia and anxiety disorders, and b) the phenome of the acute phase (based on depression, anxiety and quality of life scores). PLS analysis showed that 55.7 % of the variance in the lifetime + current phenome factor was explained by increased atherogenicity, neglect and sexual abuse, while atherogenicity partially mediated the effects of neglect. Cluster analysis generated a cluster of patients with major dysmood disorder, which was externally validated by increased atherogenicity and characterized by increased scores of all clinical features. Conclusions: The outcome of depression should not be represented as a binary variable (MDD or not), but rather as multiple dimensional scores based on biomarkers, ROI, subclinical depression traits, and lifetime and current phenome scores including SBs.
C1 [Maes, Michael; Zhou, Bo; Tang, Xiaoou; Li, Jing; Almulla, Abbas F.] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sichuan Prov Ctr Mental Hlth, Sch Med, Chengdu 610072, Peoples R China.
   [Maes, Michael; Zhou, Bo; Tang, Xiaoou; Li, Jing; Almulla, Abbas F.] Chinese Acad Med Sci, Key Lab Psychosomat Med, Chengdu 610072, Peoples R China.
   [Maes, Michael; Jirakran, Ketsupar; Vasupanrajit, Asara; Tunvirachaisakul, Chavit; Almulla, Abbas F.] Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok, Thailand.
   [Maes, Michael; Jirakran, Ketsupar; Vasupanrajit, Asara; Tunvirachaisakul, Chavit; Almulla, Abbas F.] King Chulalongkorn Mem Hosp, Thai Red Cross Soc, Bangkok, Thailand.
   [Maes, Michael; Tunvirachaisakul, Chavit] Chulalongkorn Univ, Fac Med, Cognit Impairment & Dementia Res Unit, Bangkok, Thailand.
   [Maes, Michael] Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria.
   [Maes, Michael] Med Univ Plovdiv, Res Inst, Plovdiv, Bulgaria.
   [Maes, Michael] Kyung Hee Univ, 26 Kyungheedae Ro, Seoul, South Korea.
   [Jirakran, Ketsupar] Chulalongkorn Univ, Fac Med, Ctr Excellence Maximizing Childrens Dev Potential, Dept Pediat, Bangkok, Thailand.
   [Boonchaya-Anant, Patchaya] Chulalongkorn Univ, Fac Med, Div Endocrinol & Metab, Div Endocrinol, Bangkok, Thailand.
   [Almulla, Abbas F.] Islamic Univ, Coll Med Technol, Med Lab Technol Dept, Najaf, Iraq.
C3 Sichuan Provincial People's Hospital; University of Electronic Science &
   Technology of China; Chinese Academy of Medical Sciences - Peking Union
   Medical College; Chulalongkorn University; Thai Red Cross Society;
   Chulalongkorn University; Chulalongkorn University; Medical University
   Plovdiv; Medical University Plovdiv; Kyung Hee University; Chulalongkorn
   University; Chulalongkorn University; Islamic University College
RP Li, J; Almulla, AF (corresponding author), Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sichuan Prov Ctr Mental Hlth, Sch Med, Chengdu 610072, Peoples R China.; Li, J; Almulla, AF (corresponding author), Chinese Acad Med Sci, Key Lab Psychosomat Med, Chengdu 610072, Peoples R China.; Almulla, AF (corresponding author), Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok, Thailand.; Almulla, AF (corresponding author), King Chulalongkorn Mem Hosp, Thai Red Cross Soc, Bangkok, Thailand.; Almulla, AF (corresponding author), Islamic Univ, Coll Med Technol, Med Lab Technol Dept, Najaf, Iraq.
EM cmhpublishing@uestc.edu.cn; abbass.chem.almulla1991@gmail.com
RI Almulla, Abbas F./GPW-6234-2022; Maes, Michael/B-8546-2011;
   Vasupanrajit, Asara/ABG-5437-2021
OI Maes, Michael/0000-0002-2012-871X
FU Ratchadapiseksompotch Fund, Faculty of Medicine, Chulalongkorn
   University [GA64/21]; Graduate School; King Bhumibhol Adulyadej's 72nd
   Birthday Anniversary Scholarship Chulalongkorn University; Sompoch
   Endowment Fund Faculty of Medicine, MDCU
FX This work was supported by the Ratchadapiseksompotch Fund, Faculty of
   Medicine, Chulalongkorn University (Grant number GA64/21) , a grant from
   the Graduate School and H.M. the King Bhumibhol Adulyadej's 72nd
   Birthday Anniversary Scholarship Chulalongkorn University, both to KJ,
   and the FF60 grant and Sompoch Endowment Fund from the Faculty of
   Medicine, MDCU to MM.
CR Alberti KG., 2009, Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
   Association AP, 2013, Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
   Beck AT, 1996, Beck Depression InventorySecond Edition Manual
   Gramaglia C, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00621
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Iamsupasit S, 2005, P E W PSYCH SCI RES
   Jirakran K., 2023, PREPRINT, DOI [10.1101/2023.02.10.23285746,2023.2002.2010.23285746, DOI 10.1101/2023.02.10.23285746,2023.2002.2010.23285746]
   Jirakran K, 2023, FRONT PSYCHIATRY, V14, DOI 10.3389/fpsyt.2023.1158036
   John O.P., 1999, HDB PERSONALITY THEO, P102, DOI DOI 10.1525/FQ.1998.51.4.04A00260
   Kittirattanapaiboon P., 2005, J Ment Health Thailand, V13, P126
   Luangsurong N, 2016, Relationship between big 5 personality traits and climate friendly product purchase intention
   MAES M, 1994, ACTA PSYCHIAT SCAND, V90, P252, DOI 10.1111/j.1600-0447.1994.tb01589.x
   Maes M, 1997, ACTA PSYCHIAT SCAND, V95, P212, DOI 10.1111/j.1600-0447.1997.tb09622.x
   Maes M., 2023, Toward the Use of Research and Diagnostic Algorithmic Rules to Assess the Recurrence of Illness and Major Dysmood Disorder Features: The Diagnosis "Bipolar Disorder"Is Useless, Computational Neuroscience. Neuromethods, V199, DOI [10.1007/978-1-0716-3230-7_3, DOI 10.1007/978-1-0716-3230-7_3]
   Maes M, 2023, BRAIN SCI, V13, DOI 10.3390/brainsci13050714
   Maes M, 2023, ACTA NEUROPSYCHIATR, V35, P328, DOI 10.1017/neu.2023.21
   Maes M, 2023, ACTA NEUROPSYCHIATR, V35, P104, DOI 10.1017/neu.2022.31
   Maes M, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11091564
   Maes M, 2022, J PERS MED, V12, DOI 10.3390/jpm12030403
   Maes M, 2021, METAB BRAIN DIS, V36, P509, DOI 10.1007/s11011-020-00656-6
   Maes M, 2019, MOL NEUROBIOL, V56, P6626, DOI 10.1007/s12035-019-1552-z
   Maes Michael, 2018, BioMolecular Concepts, V9, P115, DOI 10.1515/bmc-2018-0010
   Maes M, 2009, NEUROENDOCRINOL LETT, V30, P462
   Maes MH, 2022, WORLD J PSYCHIATR, V12, P651, DOI 10.5498/wjp.v12.i5.651
   Moreira EG, 2019, CURR NEUROPHARMACOL, V17, P1004, DOI 10.2174/1570159X17666181227164947
   Morelli NR, 2021, J AFFECT DISORDERS, V294, P410, DOI 10.1016/j.jad.2021.07.057
   Morris G, 2021, NEUROSCI BIOBEHAV R, V125, P244, DOI 10.1016/j.neubiorev.2021.02.037
   de Melo LGP, 2017, PROG NEURO-PSYCHOPH, V78, P34, DOI 10.1016/j.pnpbp.2017.04.027
   Posner K, 2011, AM J PSYCHIAT, V168, P1266, DOI 10.1176/appi.ajp.2011.10111704
   Rungmueanporn L., 2019, Chula Med Bull, V1, P251
   Simeonova D, 2021, NITRIC OXIDE-BIOL CH, V106, P45, DOI 10.1016/j.niox.2020.11.001
   Spielberger C. D., 1983, Manual for the State-Trait-Anxiety Inventory: STAI (form Y)
   Stoyanov D, 2021, WORLD J PSYCHIATR, V11, P1, DOI 10.5498/wjp.v11.i1.1
   Stuchtey FC, 2022, HEALTHCARE-BASEL, V10, DOI 10.3390/healthcare10020333
   Telles-Correia D, 2018, J EVAL CLIN PRACT, V24, P797, DOI [10.1111/jep.12871, 10.1111/jep.12891, 10.1111/jep.128]
   Nunes SOV, 2015, J AFFECT DISORDERS, V172, P55, DOI 10.1016/j.jad.2014.09.038
   WHO World Health Organization, 2012, The World Health Organization Quality of Life (WHOQOL)
   World Health Organization, 2019, INT STAT CLASS DIS R
NR 38
TC 10
Z9 10
U1 3
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD APR 1
PY 2024
VL 350
BP 728
EP 740
DI 10.1016/j.jad.2024.01.150
EA JAN 2024
PG 13
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA JL8P5
UT WOS:001173418100001
PM 38246281
OA Green Submitted, hybrid
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Redon, J
   Lurbe, E
AF Redon, Josep
   Lurbe, Empar
TI The Kidney in Obesity
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
DE Obesity; Proteinuria; Chronic kidney disease; Obesity glomerulopathy;
   Perivascular fat
ID BODY-MASS INDEX; GLOMERULAR-FILTRATION-RATE; CORONARY-HEART-DISEASE;
   INDEPENDENT RISK-FACTOR; STAGE RENAL-DISEASE; METABOLIC SYNDROME;
   WEIGHT-LOSS; CARDIOVASCULAR RISK; ABDOMINAL OBESITY; FAT DISTRIBUTION
AB Body mass index has been found to be the second most important contributor to relative risk for developing end state renal disease (ESRD), after proteinuria. The impact of obesity on the kidney includes a wide spectrum, from characteristic pathologic lesions to increment in urinary albumin excretion (UAE) and proteinuria/or decrease in glomerular filtration rate (GFR). The cause of renal disease associated to obesity is not well understood, but two relevant elements emerge. The first is the presence of obesity-related glomerulopathy, and the second is the fat deposit in the kidney with impact on renal haemodynamics and intrarenal regulation. The mechanisms linking obesity and renal damage are complex and include haemodynamic changes, inflammation, oxidative stress, apoptosis, and finally renal scarring. The protection of kidney damage needs to combine weight reduction with the proper control of the cardiometabolic risk factors associated, hypertension, metabolic syndrome, diabetes and dyslipidaemia. The search for specific treatments merits future research.
C1 [Redon, Josep] Univ Valencia, Hosp Clin Valencia, Hypertens Clin, Valencia, Spain.
   [Redon, Josep] INCLIVA Res Inst, Valencia, Spain.
   [Redon, Josep; Lurbe, Empar] Inst Salud Carlos III, CIBERObn, Madrid, Spain.
   [Lurbe, Empar] Univ Valencia, Hosp Gen Valencia, Obes & Cardiovasc Risk Unit Children & Adolescent, Valencia, Spain.
C3 University of Valencia; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN; Instituto de Salud Carlos III; University of Valencia
RP Redon, J (corresponding author), INCLIVA, Inst Invest Biomed, Avda Blasco Ibanez 17, Valencia 46010, Spain.
EM Josep.redon@uv.es; Empar.lurbe@uv.es
RI Redon, Josep/L-5997-2019
OI Lurbe, Empar/0000-0002-3748-5529; Redon, Josep/0000-0001-8777-6773
CR Abou-Mrad RM, 2013, AM J PHYSIOL-RENAL, V305, pF613, DOI 10.1152/ajprenal.00173.2013
   Adelman RD, 2001, J PEDIATR-US, V138, P481, DOI 10.1067/mpd.2001.113006
   Afshinnia F, 2010, NEPHROL DIAL TRANSPL, V25, P1173, DOI 10.1093/ndt/gfp640
   Ahmed SB, 2005, HYPERTENSION, V46, P1316, DOI 10.1161/01.HYP.0000190819.07663.da
   Aitken Grant R, 2014, BMJ Open, V4, pe005480, DOI 10.1136/bmjopen-2014-005480
   Alexander MP, 2009, AM J KIDNEY DIS, V53, P751, DOI 10.1053/j.ajkd.2009.01.255
   [Anonymous], NEPHROL DIAL TRANSPL
   Axelsson J, 2006, KIDNEY INT, V69, P596, DOI 10.1038/sj.ki.5000089
   Brown RNKL, 2012, NEPHROL DIAL TRANSPL, V27, P2776, DOI 10.1093/ndt/gfr757
   Chagnac A, 2003, J AM SOC NEPHROL, V14, P1480, DOI 10.1097/01.ASN.0000068462.38661.89
   Chen BD, 2010, CLIN CHIM ACTA, V411, P705, DOI 10.1016/j.cca.2010.01.038
   Chen S, 2014, DIABETES METAB, V40, P423, DOI 10.1016/j.diabet.2014.08.005
   Chen SY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0074058
   Coresh J, 2007, JAMA-J AM MED ASSOC, V298, P2038, DOI 10.1001/jama.298.17.2038
   França AKTD, 2014, INT J NEPHROL, V2014, DOI 10.1155/2014/574267
   De Cosmo S, 2013, NEPHROL DIAL TRANSPL, V28, P29, DOI 10.1093/ndt/gfs290
   de Vries APJ, 2014, LANCET DIABETES ENDO, V2, P417, DOI 10.1016/S2213-8587(14)70065-8
   Declèves AE, 2014, KIDNEY INT, V85, P611, DOI 10.1038/ki.2013.462
   Du N, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0098926
   DUCIMETIERE P, 1986, INT J OBESITY, V10, P229
   Dugan LL, 2013, J CLIN INVEST, V123, P4888, DOI 10.1172/JCI66218
   Ejerblad E, 2006, J AM SOC NEPHROL, V17, P1695, DOI 10.1681/ASN.2005060638
   Felizardo Raphael Jose Ferreira, 2014, World J Nephrol, V3, P50, DOI 10.5527/wjn.v3.i3.50
   Finucane MM, 2011, LANCET, V377, P557, DOI 10.1016/S0140-6736(10)62037-5
   Folsom AR, 1998, AM J EPIDEMIOL, V148, P1187, DOI 10.1093/oxfordjournals.aje.a009608
   Folsom AR, 2000, ARCH INTERN MED, V160, P2117, DOI 10.1001/archinte.160.14.2117
   Foster MC, 2011, HYPERTENSION, V58, P784, DOI 10.1161/HYPERTENSIONAHA.111.175315
   Fox CS, 2004, JAMA-J AM MED ASSOC, V291, P844, DOI 10.1001/jama.291.7.844
   Franceschini N, 2014, CLIN J AM SOC NEPHRO
   Gelber RP, 2008, J AM COLL CARDIOL, V52, P605, DOI 10.1016/j.jacc.2008.03.066
   Go AS, 2004, NEW ENGL J MED, V351, P1296, DOI 10.1056/NEJMoa041031
   Goknar N, 2015, PEDIATR NEPHROL, V30, P139, DOI 10.1007/s00467-014-2829-0
   Hanly PJ, 2014, CHEST, V146, P1114, DOI 10.1378/chest.14-0596
   Hashimoto Y, 2015, CLIN J AM SOC NEPHRO
   Hoogeveen EK, 2012, CLIN J AM SOC NEPHRO, V7, P280, DOI 10.2215/CJN.05700611
   Hoogeveen EK, 2011, TRANSPLANTATION, V91, P869, DOI 10.1097/TP.0b013e3182100f3a
   Hsu CY, 2009, ARCH INTERN MED, V169, P342, DOI 10.1001/archinternmed.2008.605
   Imig JD, 2012, EXP BIOL MED, V237, P1402, DOI 10.1258/ebm.2012.012225
   Iseki K, 2004, KIDNEY INT, V65, P1870, DOI 10.1111/j.1523-1755.2004.00582.x
   Ix JH, 2010, J AM SOC NEPHROL, V21, P406, DOI 10.1681/ASN.2009080820
   Kambham N, 2001, KIDNEY INT, V59, P1498, DOI 10.1046/j.1523-1755.2001.0590041498.x
   Kang YS, 2010, KIDNEY INT, V78, P170, DOI 10.1038/ki.2010.98
   Komura Hiroshi, 2013, BMC Res Notes, V6, P463, DOI 10.1186/1756-0500-6-463
   Krikken JA, 2007, KIDNEY INT, V71, P260, DOI 10.1038/sj.ki.5002011
   Kurella M, 2005, J AM SOC NEPHROL, V16, P2134, DOI 10.1681/ASN.2005010106
   Kurth T, 2002, ARCH INTERN MED, V162, P2557, DOI 10.1001/archinte.162.22.2557
   Lakka HM, 2002, EUR HEART J, V23, P706, DOI 10.1053/euhj.2001.2889
   LAPIDUS L, 1984, BMJ-BRIT MED J, V289, P1257, DOI 10.1136/bmj.289.6454.1257
   Liu YH, 2010, J AM SOC NEPHROL, V21, P212, DOI 10.1681/ASN.2008121226
   Lurbe E, 2013, J HYPERTENS, V31, P2230, DOI 10.1097/HJH.0b013e328364bcbf
   Manabe I, 2011, CIRC J, V75, P2739, DOI 10.1253/circj.CJ-11-1184
   Pascual JM, 2014, HYPERTENSION, V64, P1228, DOI 10.1161/HYPERTENSIONAHA.114.04273
   Matsusaka T, 2011, J AM SOC NEPHROL, V22, P1275, DOI 10.1681/ASN.2010090963
   Matsushita K, 2010, LANCET, V375, P2073, DOI 10.1016/S0140-6736(10)60674-5
   Meier-Kriesche HU, 2002, TRANSPLANTATION, V73, P70, DOI 10.1097/00007890-200201150-00013
   Mohsen A, 2012, J NEPHROL, V25, P384, DOI 10.5301/jn.5000062
   Molarius A, 1999, INT J OBESITY, V23, P116, DOI 10.1038/sj.ijo.0800772
   Morales E, 2003, AM J KIDNEY DIS, V41, P319, DOI 10.1053/ajkd.2003.50039
   Musso G, 2014, PLOS MED, V11, DOI 10.1371/journal.pmed.1001680
   Nashar K, 2014, DIABET METAB SYND OB, V7, P421, DOI 10.2147/DMSO.S45183
   Nasrallah MP, 2013, SEMIN NEPHROL, V33, P54, DOI 10.1016/j.semnephrol.2012.12.005
   Navaneethan SD, 2009, CLIN J AM SOC NEPHRO, V4, P1565, DOI 10.2215/CJN.02250409
   Nishiyama A, 2006, J PHARMACOL SCI, V100, P9, DOI 10.1254/jphs.FMJ05003X3
   Nolan E, 2013, NEPHROL DIAL TRANSPL, V28, P22, DOI 10.1093/ndt/gft392
   Odagiri K, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0088873
   Panwar B, 2014, KIDNEY INT
   Pierine DT, 2014, NUTR DIABETES, V4, DOI 10.1038/nutd.2014.39
   Pohl MA, 2005, J AM SOC NEPHROL, V16, P3027, DOI 10.1681/ASN.2004110919
   Praga M, 2000, KIDNEY INT, V58, P2111, DOI 10.1046/j.1523-1755.2000.00384.x
   Redon J, 2008, J HYPERTENS, V26, P1891, DOI 10.1097/HJH.0b013e328302ca38
   Rexrode KM, 1997, JAMA-J AM MED ASSOC, V277, P1539, DOI 10.1001/jama.277.19.1539
   RIBSTEIN J, 1995, HYPERTENSION, V26, P610, DOI 10.1161/01.HYP.26.4.610
   RIMM EB, 1995, AM J EPIDEMIOL, V141, P1117, DOI 10.1093/oxfordjournals.aje.a117385
   Rutkowski JM, 2013, J AM SOC NEPHROL, V24, P268, DOI 10.1681/ASN.2012040414
   Saiki A, 2005, INT J OBESITY, V29, P1115, DOI 10.1038/sj.ijo.0803009
   Serra A, 2008, KIDNEY INT, V73, P947, DOI 10.1038/sj.ki.5002796
   Sharma D, 2014, CLIN J AM SOC NEPHRO, V9, P2079, DOI 10.2215/CJN.02140214
   Sharma K, 2014, KIDNEY INT SUPPL, V4, P113, DOI 10.1038/kisup.2014.21
   Shaw PKC, 2007, DIABETES CARE, V30, P1840, DOI 10.2337/dc07-0028
   Song H, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0113450
   Song YM, 2015, CLIN EXP NEPHROL
   Stacchiotti A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0111141
   Stengel B, 2003, EPIDEMIOLOGY, V14, P479, DOI 10.1097/01.EDE.0000071413.55296.c4
   Tang JH, 2012, INT J NEPHROL, V2012, DOI 10.1155/2012/608397
   Thoenes M, 2009, VASC HEALTH RISK MAN, V5, P577
   Thomas G, 2011, CLIN J AM SOC NEPHRO, V6, P2364, DOI 10.2215/CJN.02180311
   Tozawa M, 2002, KIDNEY INT, V62, P956, DOI 10.1046/j.1523-1755.2002.00506.x
   Vupputuri S, 2009, AM J KIDNEY DIS, V53, P993, DOI 10.1053/j.ajkd.2008.12.043
   Wagner R, 2012, DIABETOLOGIA, V55, P2054, DOI 10.1007/s00125-012-2551-z
   Wang CF, 2014, CELL PHYSIOL BIOCHEM, V33, P1139, DOI 10.1159/000358683
   Whitlock G, 2009, LANCET, V373, P1083, DOI 10.1016/S0140-6736(09)60318-4
   Wolf G, 2002, AM J KIDNEY DIS, V39, P1, DOI 10.1053/ajkd.2002.29865
   Xiao NZ, 2014, OBESITY, V22, P2319, DOI 10.1002/oby.20870
   Yoshida S, 2014, NEPHRON EXP NEPHROL, V126, P16, DOI 10.1159/000358758
   Yusuf S, 2005, LANCET, V366, P1640, DOI 10.1016/S0140-6736(05)67663-5
NR 95
TC 32
Z9 33
U1 0
U2 16
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD JUN
PY 2015
VL 17
IS 6
AR 43
DI 10.1007/s11906-015-0555-z
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CI2WW
UT WOS:000354609700004
PM 25893477
DA 2025-06-11
ER

PT J
AU Mazidi, M
   Kengne, AP
   Sahebkar, A
   Banach, M
AF Mazidi, Mohsen
   Kengne, Andre Pascal
   Sahebkar, Amirhossein
   Banach, Maciej
TI Telomere Length Is Associated With Cardiometabolic Factors in US Adults
SO ANGIOLOGY
LA English
DT Article
DE telomere length; cardiometabolic factors; cardiovascular disease
ID C-REACTIVE PROTEIN; CARDIOVASCULAR RISK-FACTORS; BODY-MASS INDEX;
   METABOLIC SYNDROME; NATIONAL-HEALTH; SOCIOECONOMIC-STATUS; OBESITY;
   BLOOD; DYNAMICS; STRESS
AB Telomere length (TL) has been associated with age-related health outcomes. We investigated the relationship of TL with cardiometabolic risk profile in adult Americans. We used the National Health and Nutrition Examination Surveys for 1999 to 2002, accounting for complex sampling and survey design. Of the 8892 eligible participants, 47.8% (n = 4123) were men. Mean serum high-density lipoprotein cholesterol concentrations significantly increased across increasing TL quarters (P = .013), and mean fat mass, fat-free mass, hemoglobin A(1c) (HbA(1c)), and C-reactive protein significantly decreased across increasing TL quarters (all P < .001) in men. Only HbA(1c) levels significantly decreased across increasing TL quarters (P = .041) in women. Males in the upper quarter of TL had lower (38%) odds of prevalent metabolic syndrome compared with those in the lower quarter (P < .001). These results support the hypotheses that cardiometabolic factors are related to TL, especially in men.
C1 [Mazidi, Mohsen] Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100101, Peoples R China.
   [Mazidi, Mohsen] Univ Chinese Acad Sci, Inst Genet & Dev Biol, Int Coll, Beijing, Peoples R China.
   [Kengne, Andre Pascal] South African Med Res Council, Noncommunicable Dis Res Unit, Cape Town, South Africa.
   [Kengne, Andre Pascal] Univ Cape Town, Dept Med, Cape Town, South Africa.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran.
   [Banach, Maciej] Med Univ Lodz, Dept Hypertens, Chair Nephrol & Hypertens, Lodz, Poland.
   [Banach, Maciej] PMMHRI, Lodz, Poland.
C3 Chinese Academy of Sciences; Institute of Genetics & Developmental
   Biology, CAS; Chinese Academy of Sciences; University of Chinese Academy
   of Sciences, CAS; Institute of Genetics & Developmental Biology, CAS;
   South African Medical Research Council; University of Cape Town; Mashhad
   University of Medical Sciences; Medical University Lodz
RP Mazidi, M (corresponding author), Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100101, Peoples R China.
EM moshen@genetics.ac.cn
RI Linn, Shai/N-3079-2019; Kengne, Andre/ABB-3696-2020; Sahebkar,
   Amirhossein/B-5124-2018; Banach, Maciej/A-1271-2009
OI Kengne, Andre Pascal/0000-0002-5183-131X; Banach,
   Maciej/0000-0001-6690-6874
FU World Academy of Sciences studentship of the Chinese Academy of Sciences
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: MM was
   supported by The World Academy of Sciences studentship of the Chinese
   Academy of Sciences during the preparation of this manuscript.
CR Adams J, 2007, AGING CELL, V6, P125, DOI 10.1111/j.1474-9726.2006.00258.x
   [Anonymous], SCI AGING KNOWLEDGE
   Ansell BJ, 2007, AM J CARDIOL, V100, p3N, DOI 10.1016/j.amjcard.2007.08.006
   Aubert G, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002696
   Bekaert S, 2007, AGING CELL, V6, P639, DOI 10.1111/j.1474-9726.2007.00321.x
   BLACKBURN EH, 1991, NATURE, V350, P569, DOI 10.1038/350569a0
   Boccardi V, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0062781
   Cawthon RM, 2003, LANCET, V361, P393, DOI 10.1016/S0140-6736(03)12384-7
   Chen W, 2011, J GERONTOL A-BIOL, V66, P312, DOI 10.1093/gerona/glq223
   Chen W, 2009, ATHEROSCLEROSIS, V205, P620, DOI 10.1016/j.atherosclerosis.2009.01.021
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   Codd V, 2013, NAT GENET, V45, P422, DOI 10.1038/ng.2528
   Fitzpatrick AL, 2007, AM J EPIDEMIOL, V165, P14, DOI [10.1093/aje/kw346, 10.1093/aje/kwj346]
   García-Calzón S, 2014, INT J OBESITY, V38, P177, DOI 10.1038/ijo.2013.68
   Gardner M, 2014, EXP GERONTOL, V51, P15, DOI 10.1016/j.exger.2013.12.004
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Guzzardi MA, 2015, ANN MED, V47, P499, DOI 10.3109/07853890.2015.1074718
   Harte AL, 2012, EXP DIABETES RES, DOI 10.1155/2012/895185
   Lin J, 2011, BRAIN RES, V1379, P224, DOI 10.1016/j.brainres.2010.10.033
   Ma YS, 2006, AM J CLIN NUTR, V83, P760, DOI 10.1093/ajcn/83.4.760
   Mazidi M, 2017, NUTR DIABETES, V7, DOI 10.1038/nutd.2017.11
   Mazidi M, 2018, ANN MED, V50, P1, DOI 10.1080/07853890.2017.1325967
   Mazidi M, 2020, EUR J CLIN INVEST, V50, DOI 10.1111/eci.12745
   Mazidi M, 2017, ARCH MED SCI, V13, P601, DOI 10.5114/aoms.2017.67281
   Mazidi M, 2017, POL ARCH INTERN MED, V127, P87, DOI 10.20452/pamw.3927
   Mazidi M, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000005736
   Mazidi M, 2017, ARCH MED SCI, V13, P61, DOI 10.5114/aoms.2017.64714
   Möller P, 2009, AGING-US, V1, P733
   Müezzinler A, 2014, OBES REV, V15, P192, DOI 10.1111/obr.12126
   Needham BL, 2013, SOC SCI MED, V85, P1, DOI 10.1016/j.socscimed.2013.02.023
   Nordfjäll K, 2008, OBESITY, V16, P2682, DOI 10.1038/oby.2008.413
   O'Callaghan NJ, 2009, REJUV RES, V12, P169, DOI 10.1089/rej.2008.0819
   O'Donovan A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019687
   Okuda K, 2002, PEDIATR RES, V52, P377, DOI 10.1203/01.PDR.0000022341.72856.72
   Prasad K, 2004, J CARDIOVASC PHARM T, V9, P203, DOI 10.1177/107424840400900308
   Révész D, 2015, J CLIN ENDOCR METAB, V100, P3050, DOI 10.1210/JC.2015-1995
   Rode L, 2014, J CLIN ENDOCR METAB, V99, pE1671, DOI 10.1210/jc.2014-1161
   Sahin E, 2011, NATURE, V470, P359, DOI 10.1038/nature09787
   Shiels PG, 2010, J GERONTOL A-BIOL, V65, P789, DOI 10.1093/gerona/glq095
   Shoelson SE, 2007, GASTROENTEROLOGY, V132, P2169, DOI 10.1053/j.gastro.2007.03.059
   Valdes AM, 2005, LANCET, V366, P662, DOI 10.1016/S0140-6736(05)66630-5
   von Zglinicki T, 2002, TRENDS BIOCHEM SCI, V27, P339, DOI 10.1016/S0968-0004(02)02110-2
   Weng NP, 2001, J LEUKOCYTE BIOL, V70, P861
NR 43
TC 37
Z9 39
U1 0
U2 16
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD FEB
PY 2018
VL 69
IS 2
BP 164
EP 169
DI 10.1177/0003319717712860
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FR5RM
UT WOS:000419123900011
PM 28583002
DA 2025-06-11
ER

PT J
AU Dearman, A
   Bao, YC
   Schalkwyk, L
   Kumari, M
AF Dearman, Anna
   Bao, Yanchun
   Schalkwyk, Leonard
   Kumari, Meena
TI Serum proteomic correlates of mental health symptoms in a representative
   UK population sample
SO BRAIN BEHAVIOR & IMMUNITY-HEALTH
LA English
DT Article
DE Proteomics; Proximity extension assay; Mental health; Psychological
   distress; Population health
ID MAJOR DEPRESSIVE DISORDER; PROTEIN-C INHIBITOR; METABOLIC SYNDROME;
   BLOOD-COAGULATION; NK CELLS; STRESS; SCHIZOPHRENIA; INFLAMMATION;
   ASSOCIATIONS; METAANALYSIS
AB Poor mental health constitutes a public health crisis due to its high prevalence, unmet need and its mechanistic heterogeneity. A comprehensive understanding of the biological correlates of poor mental health in the population could enhance epidemiological research and eventually help guide treatment strategies. The human bloodstream contains many proteins, several of which have been linked to diagnosed mental health conditions but not to population mental health symptoms, however recent technological advances have made this possible. Here we perform exploratory factor analyses of 184 proteins from two panels (cardiometabolic and neurologyrelated) measured using proximity extension assays from Understanding Society (the UK Household Longitudinal Study; UKHLS). Data reduction results in 28 factors that explain 55-59% of the variance per panel. We perform multiple linear regressions in up to 5304 participants using two mental health symptom-based outcomes: psychological distress assessed with the general health questionnaire (GHQ-12) and mental health functioning assessed with the 12-Item Short Form Survey, Mental Component Summary (SF12-MCS) using the proteomic factors as explanatory variables and adjusting for demographic covariates. We use backward selection to discard non-significant proteomic factors from the models. Ten factors are independently associated with population mental health symptoms, three of which are immune-related (immunometabolism, immune cell-mediated processes, acute phase processes), three brain-related (neurodevelopment, synaptic processes, neuroprotective processes), two proteolysis-related (proteolysis & the kynurenine pathway, haemostasis & proteolysis), growth factors & muscle, and oxidative stress & the cytoskeleton. Associations partially overlap across the two outcomes, and a sensitivity analysis excluding people taking antidepressants or other central nervous system medications suggestively implicates some of the factors in treatment-resistant poor mental health. Our findings replicate those of case-control studies and expand these to underlie mental health symptomatology in the adult population. More work is needed to understand the direction of causality in these associations.
C1 [Dearman, Anna; Kumari, Meena] Univ Essex, Inst Social & Econ Res, Wivenhoe Pk, Colchester CO4 3SQ, Essex, England.
   [Bao, Yanchun] Univ Essex, Sch Math Stat & Actuarial Sci SMSAS, Wivenhoe Pk, Colchester CO4 3SQ, Essex, England.
   [Schalkwyk, Leonard] Univ Essex, Sch Life Sci, Wivenhoe Pk, Colchester CO4 3SQ, Essex, England.
C3 University of Essex; University of Essex; University of Essex
RP Dearman, A (corresponding author), Univ Essex, Inst Social & Econ Res, Wivenhoe Pk, Colchester CO4 3SQ, Essex, England.
EM ad21432@essex.ac.uk
RI Dearman, Anna/MVU-8375-2025
FU Economic and Social Research Council (ESRC); ESRC [ES/S007253/1,
   ES/S012486/1, ES/N00812X/1, ES/T014083/1]; University of Essex, ESRC; 
   [MR/W004984/1];  [RES-596-28-0001]
FX Understanding Society is an initiative funded by the Economic and Social
   Research Council (ESRC) and various Government Departments, with
   scientific leadership by the Institute for Social and Economic Research,
   University of Essex, and survey delivery by NatCen Social Research and
   Kantar Public. The research data are distributed by the UK Data Service.
   A.D. was supported by the ESRC (ES/S007253/1 & ES/S012486/1) . Y.B. was
   partially supported by the ESRC (ES/N00812X/1) . L.S. is supported by
   MR/W004984/1. M.K. is supported by the University of Essex, ESRC
   (RES-596-28-0001) and ESRC (ES/S012486/1; ES/T014083/1) . The funders
   had no involvement in the analysis or preparation of the paper. We thank
   Professor Paul Clarke for his advice during this project. We would also
   like to thank the study participants who gave their time and blood
   samples to support Understanding Society's research.
CR Afonin AM, 2024, TRANSL PSYCHIAT, V14, DOI 10.1038/s41398-024-02751-z
   Ahmad S, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-65038-5
   Al-Mazidi SH, 2023, BRAIN SCI, V13, DOI 10.3390/brainsci13060972
   Arase N, 2005, INT IMMUNOL, V17, P1227, DOI 10.1093/intimm/dxh299
   Arnau-Soler A, 2019, TRANSL PSYCHIAT, V9, DOI 10.1038/s41398-018-0360-y
   Assarsson E, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0095192
   Austin AW, 2013, SEMIN THROMB HEMOST, V39, P902, DOI 10.1055/s-0033-1357487
   Baczek J, 2020, NUTRIENTS, V12, DOI 10.3390/nu12082401
   Bayes-Genis A, 2016, J AM COLL CARDIOL, V68, P639, DOI 10.1016/j.jacc.2016.04.060
   Bernimoulin MP, 2003, J BIOL CHEM, V278, P37, DOI 10.1074/jbc.M204360200
   Blosa M, 2015, J PHYSIOL-LONDON, V593, P4341, DOI 10.1113/JP270849
   Boldyrev AA, 2013, PHYSIOL REV, V93, P1803, DOI 10.1152/physrev.00039.2012
   Branchi I, 2021, EUR NEUROPSYCHOPHARM, V45, P89, DOI 10.1016/j.euroneuro.2020.11.016
   British Medical Association Royal Pharmaceutical Society of Great Britain, 2009, British National Formulary: March 2009
   Bui TM, 2020, J LEUKOCYTE BIOL, V108, P787, DOI 10.1002/JLB.2MR0220-549R
   Bunin A, 2015, IMMUNITY, V43, P277, DOI 10.1016/j.immuni.2015.07.009
   Butler MG, 2015, INT J MOL SCI, V16, P6464, DOI 10.3390/ijms16036464
   Carpenter KM, 2000, AM J PUBLIC HEALTH, V90, P251, DOI 10.2105/AJPH.90.2.251
   Cathomas F, 2024, NATURE, V626, DOI 10.1038/s41586-023-07015-2
   Cobas, 2014, Serum index Gen.2 order information
   Comes AL, 2018, TRANSL PSYCHIAT, V8, DOI 10.1038/s41398-018-0219-2
   Dahlbäck B, 2005, ARTERIOSCL THROM VAS, V25, P1311, DOI 10.1161/01.ATV.0000168421.13467.82
   Dearman A., 2023, Understanding Society Working Paper Series
   Dearman A., 2023, Understanding society proteomics user guide
   Deiteren K, 2009, CLIN CHIM ACTA, V399, P24, DOI 10.1016/j.cca.2008.10.003
   Dhindsa RS, 2023, NATURE, V622, P339, DOI 10.1038/s41586-023-06547-x
   Dityatev A, 2021, EUR J NEUROSCI, V53, P3807, DOI 10.1111/ejn.15336
   Dordevic N, 2023, medRxiv, DOI [10.1101/2023.10.11.23296871, 10.1101/ 2023.10.11.23296871, DOI 10.1101/2023.10.11.23296871]
   Eldjarn GH, 2023, NATURE, V622, P348, DOI 10.1038/s41586-023-06563-x
   Elisen MGLM, 1998, BLOOD, V91, P1542, DOI 10.1182/blood.V91.5.1542.1542_1542_1547
   Fang K, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10123314
   Fawcett JW, 2019, NAT REV NEUROSCI, V20, P451, DOI 10.1038/s41583-019-0196-3
   Foley EM, 2023, MOL PSYCHIATR, V28, P1004, DOI 10.1038/s41380-022-01919-7
   GBD 2019 Mental Disorders Collaborators, 2022, Lancet Psychiatry, V9, P137, DOI [10.1016/S2215-0366(21)00395-3, DOI 10.1016/S2215-0366(21)00395-3]
   Goldberg DP, 1997, PSYCHOL MED, V27, P191, DOI 10.1017/S0033291796004242
   Goldsmith DR, 2016, MOL PSYCHIATR, V21, P1696, DOI 10.1038/mp.2016.3
   Grune T, 2002, FASEB J, V16, P1602, DOI 10.1096/fj.02-0015com
   Guder W.G., 2000, LABORATORIUMSMEDIZIN
   Guest PC, 2016, INT J NEUROPSYCHOPH, V19, DOI 10.1093/ijnp/pyv138
   Halaris A., 2019, Neurol. Psychiatr. Brain Res., V32, P111, DOI [10.1016/j.npbr.2019.05.005, DOI 10.1016/J.NPBR.2019.05.005]
   Harris SE, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-019-14161-7
   He CH, 2023, CELL DEATH DIS, V14, DOI 10.1038/s41419-023-05825-w
   He GZ, 2021, J CELL MOL MED, V25, P6815, DOI 10.1111/jcmm.16685
   Hernandez LM, 2023, GENOME BIOL, V24, DOI 10.1186/s13059-023-02878-0
   Hill MD, 2024, MOL PSYCHIATR, V29, P1528, DOI 10.1038/s41380-024-02433-8
   Hoy N, 2023, NEUROSCI BIOBEHAV R, V155, DOI 10.1016/j.neubiorev.2023.105431
   Hsia HE, 2019, CELL MOL LIFE SCI, V76, P3055, DOI 10.1007/s00018-019-03173-7
   Huang J, 2021, MOL CELL PROTEOMICS, V20, DOI 10.1016/j.mcpro.2021.100157
   Hughes A, 2017, BRAIN BEHAV IMMUN, V66, P89, DOI 10.1016/j.bbi.2017.07.009
   Ivetic A, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.01068
   Jiang J, 2019, ANTIOXID REDOX SIGN, V31, P579, DOI 10.1089/ars.2019.7805
   Jiang MS, 2004, BIOCHEM BIOPH RES CO, V315, P525, DOI 10.1016/j.bbrc.2004.01.085
   Khoury R, 2018, SCHIZOPHR RES, V199, P31, DOI 10.1016/j.schres.2018.04.017
   Kim JR, 2018, DIABETOL METAB SYNDR, V10, DOI 10.1186/s13098-018-0367-9
   Kim ST, 2010, J PHYSIOL SCI, V60, P27, DOI 10.1007/s12576-009-0061-7
   Kotov R, 2017, J ABNORM PSYCHOL, V126, P454, DOI 10.1037/abn0000258
   Kurkinen K, 2023, EUR J PSYCHOTRAUMATO, V14, DOI 10.1080/20008066.2023.2191396
   Lai MC, 2019, LANCET PSYCHIAT, V6, P819, DOI 10.1016/S2215-0366(19)30289-5
   Le-Niculescu H, 2021, MOL PSYCHIATR, V26, P2776, DOI 10.1038/s41380-021-01061-w
   Liu S, 2023, BIOL PSYCHIAT-COGN N, V8, P300, DOI 10.1016/j.bpsc.2022.08.003
   Lynn P., 2009, Understanding Society Working Paper, P2009
   Maciel ID, 2023, NAT MENT HEALTH, V1, DOI 10.1038/s44220-023-00103-2
   MAES M, 1995, PSYCHONEUROENDOCRINO, V20, P111, DOI 10.1016/0306-4530(94)00066-J
   Maes M, 2018, MOL NEUROBIOL, V55, P8885, DOI 10.1007/s12035-018-1016-x
   Majd M, 2020, FRONT NEUROENDOCRIN, V56, DOI 10.1016/j.yfrne.2019.100800
   McManus S., 2016, Mental health and wellbeing in England: adult psychiatric morbidity survey 2014
   Michopoulos V, 2017, NEUROPSYCHOPHARMACOL, V42, P254, DOI 10.1038/npp.2016.146
   Mühleisen TW, 2012, SCHIZOPHR RES, V138, P69, DOI 10.1016/j.schres.2012.03.007
   Niemeyer C, 2020, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.00718
   Nousen EK, 2013, NEUROENDOCRINOLOGY, V98, P254, DOI 10.1159/000355632
   Oncul S, 2020, CURR OPIN HEMATOL, V27, P341, DOI 10.1097/MOH.0000000000000605
   Osterhout JA, 2014, CELL REP, V8, P1006, DOI 10.1016/j.celrep.2014.06.063
   Ouimette P, 2008, J ANXIETY DISORD, V22, P337, DOI 10.1016/j.janxdis.2007.02.010
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pardo J, 2002, EUR J IMMUNOL, V32, P2881, DOI 10.1002/1521-4141(2002010)32:10<2881::AID-IMMU2881>3.0.CO;2-K
   Park SH, 2003, J IMMUNOL, V170, P1197, DOI 10.4049/jimmunol.170.3.1197
   Pedersen BK, 2019, NAT REV ENDOCRINOL, V15, P383, DOI 10.1038/s41574-019-0174-x
   Phillips RS, 2014, ARCH BIOCHEM BIOPHYS, V544, P69, DOI 10.1016/j.abb.2013.10.020
   Plurphanswat N, 2017, AM J HEALTH BEHAV, V41, P471, DOI 10.5993/AJHB.41.4.12
   Preston G, 2018, J INHERIT METAB DIS, V41, P585, DOI 10.1007/s10545-018-0168-1
   Pries LK, 2020, EPIDEMIOL PSYCH SCI, V29, DOI 10.1017/S2045796020000943
   Revelle William, 2024, CRAN
   Ruggeri FS, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19092582
   Salaheddin K, 2016, BRIT J GEN PRACT, V66, pE686, DOI 10.3399/bjgp16X687313
   García-Gutiérrez MS, 2020, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.00432
   Sanderson K, 2002, PSYCHIATR SERV, V53, P80, DOI 10.1176/appi.ps.53.1.80
   Sasaki Y, 2016, ELIFE, V5, DOI 10.7554/eLife.19749
   Schlag F, 2022, MOL PSYCHIATR, V27, P1588, DOI 10.1038/s41380-021-01419-0
   Siebold C, 2017, TRENDS CELL BIOL, V27, P365, DOI 10.1016/j.tcb.2016.11.009
   Skorobogatov K, 2023, BRAIN BEHAV IMMUN-HL, V27, DOI 10.1016/j.bbih.2022.100584
   Slavich GM, 2014, PSYCHOL BULL, V140, P774, DOI 10.1037/a0035302
   Smirnova L, 2019, BMC GENOMICS, V20, DOI 10.1186/s12864-019-5848-1
   Song BG, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23116218
   Stephens JM, 2018, OBESITY, V26, P1439, DOI 10.1002/oby.22254
   Stunkard AJ, 2003, BIOL PSYCHIAT, V54, P330, DOI 10.1016/S0006-3223(03)00608-5
   Taylor JH, 2020, BIOL PSYCHIAT, V88, P337, DOI 10.1016/j.biopsych.2020.02.002
   Tian YE, 2023, JAMA PSYCHIAT, V80, P567, DOI 10.1001/jamapsychiatry.2023.0791
   Uhlhaas PJ, 2023, MOL PSYCHIATR, V28, P3171, DOI 10.1038/s41380-023-02202-z
   Ulbrich P, 2021, EUR J NEUROSCI, V53, P3811, DOI 10.1111/ejn.14887
   University of Essex Institute for Social and Economic Research, 2023, UKDA, DOI 10.5255/UKDA-SN-7251-5
   University of Essex Institute for Social and Economic Research, 2021, UKDA
   van Os J, 1999, SOC PSYCH PSYCH EPID, V34, P459, DOI 10.1007/s001270050220
   van Ton AMP, 2020, BRAIN BEHAV IMMUN, V89, P656, DOI 10.1016/j.bbi.2020.06.027
   Vega IE, 2018, CURR ALZHEIMER RES, V15, P1086, DOI 10.2174/1567205015666180813152043
   Vigo D, 2016, LANCET PSYCHIAT, V3, P171, DOI 10.1016/S2215-0366(15)00505-2
   von Känel R, 2001, PSYCHOSOM MED, V63, P531, DOI 10.1097/00006842-200107000-00003
   Ware JE., 1995, SF-12: how to score the SF-12 physical and mental health summary scales, V2nd ed.
   Waszczuk MA, 2023, TRANSL PSYCHIAT, V13, DOI 10.1038/s41398-022-02302-4
   Wendt FR, 2021, NEUROBIOL STRESS, V14, DOI 10.1016/j.ynstr.2021.100309
   West NR, 2017, NAT MED, V23, P579, DOI 10.1038/nm.4307
   Westphal M, 2011, DEPRESS ANXIETY, V28, P686, DOI 10.1002/da.20842
   Woo JJ, 2020, MOL PSYCHIATR, V25, P114, DOI 10.1038/s41380-019-0479-0
   Yang HJ, 2017, SEMIN CELL DEV BIOL, V62, P187, DOI 10.1016/j.semcdb.2016.10.007
   Zhang Y, 2023, J MOL CELL BIOL, V15, DOI 10.1093/jmcb/mjad053
   Zheng J, 2020, NAT GENET, V52, P1122, DOI 10.1038/s41588-020-0682-6
NR 115
TC 0
Z9 0
U1 2
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2666-3546
J9 BRAIN BEHAV IMMUN-HL
JI Brain Behav. Immun.-Health
PD MAR
PY 2025
VL 44
AR 100947
DI 10.1016/j.bbih.2025.100947
EA JAN 2025
PG 12
WC Immunology; Neurosciences; Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA W2A3W
UT WOS:001416663700001
PM 39911945
OA gold
DA 2025-06-11
ER

PT J
AU Amiri, P
   Deihim, T
   Hosseinpanah, F
   Barzin, M
   Hasheminia, M
   Montazeri, A
   Azizi, F
AF Amiri, P.
   Deihim, T.
   Hosseinpanah, F.
   Barzin, M.
   Hasheminia, M.
   Montazeri, A.
   Azizi, F.
TI Diagnostic values of different definitions of metabolic syndrome to
   detect poor health status in Iranian adults without diabetes
SO DIABETIC MEDICINE
LA English
DT Article
ID QUALITY-OF-LIFE; CARDIOVASCULAR RISK; PROVISIONAL REPORT; POPULATION;
   ASSOCIATION; DEPRESSION; GLUCOSE; PREVALENCE; DISEASE; IMPACT
AB Aims This study aimed to compare the diagnostic impact of four definitions of the metabolic syndrome for detection of poor health status in adults without diabetes living in Tehran. Methods A representative sample of 950 individuals (64% women), aged 20years, participants of the Tehran Lipid and Glucose Study in 2005-2007, were recruited for the study. Health status was assessed using the Iranian version of the 36-item Short Form Health Survey. We assessed the detectability of poor health status by definitions of the National Cholesterol Education Program Adult Treatment PanelIII, the International Diabetes Federation, the American Heart Association/National Heart, Lung, and the Blood Institute and the Joint Interim Statement. Results Compared with other definitions, the Joint Interim Statement identified more participants (46.9%) having the metabolic syndrome. Using the National Cholesterol Education Program Adult Treatment Panel III, the International Diabetes Federation and the Joint Interim Statement, the metabolic syndrome was significantly related to poor physical health status, even after adjustment for confounding variables, in women, but not in men. None of the four definitions of the metabolic syndrome was related to the mental health status in either gender. The receiver operating characteristic curves showed no significant difference in the discriminative power of the metabolic syndrome definitions in detecting poor health status in either gender. However, women showed a higher area under the curve for all definitions, in comparison with men. Conclusion There was no difference in the four different definitions of the metabolic syndrome in detecting poor health status among Iranian adults.
C1 [Amiri, P.; Deihim, T.] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Res Ctr Social Determinants Endocrine Hlth, Tehran, Iran.
   [Amiri, P.; Deihim, T.; Hosseinpanah, F.; Barzin, M.; Hasheminia, M.] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Obes Res Ctr, Tehran, Iran.
   [Montazeri, A.] ACECR, Iranian Inst Hlth Sci Res, Hlth Metr Res Ctr, Mental Hlth Res Grp, Tehran, Iran.
   [Azizi, F.] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Res Ctr, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Academic Center for Education, Culture & Research
   (ACECR); Shahid Beheshti University Medical Sciences
RP Hosseinpanah, F (corresponding author), Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Obes Res Ctr, Tehran, Iran.
EM fhospanah@endocrine.ac.ir
RI Montazeri, Ali/C-9276-2009; hosseinpanah, farhad/AAM-7277-2020;
   Hasheminia, Mitra/IXD-5283-2023; Amiri, Parisa/K-1575-2017; Azizi,
   Fereidoun/ABD-4136-2021
OI Amiri, Parisa/0000-0002-6693-1057; Azizi, Fereidoun/0000-0002-6470-2517;
   Montazeri, Ali/0000-0002-5198-9539
FU Research Institute for Endocrine Sciences, Shahid Beheshti University of
   Medical Sciences, Tehran, Iran
FX This study is funded by the Research Institute for Endocrine Sciences,
   Shahid Beheshti University of Medical Sciences, Tehran, Iran.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Amiri P, 2010, J WOMENS HEALTH, V19, P1201, DOI 10.1089/jwh.2009.1710
   Azizi F, 2002, SOZ PRAVENTIV MED, V47, P408, DOI 10.1007/s000380200008
   Azizi F, 2009, TRIALS, V10, DOI 10.1186/1745-6215-10-5
   Balkau B, 1999, DIABETIC MED, V16, P442
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Corica F, 2008, INT J OBESITY, V32, P185, DOI 10.1038/sj.ijo.0803687
   Delavari A, 2009, DIABETES CARE, V32, P1092, DOI 10.2337/dc08-1800
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   Eckel RH, 2010, LANCET, V375, P181, DOI 10.1016/S0140-6736(09)61794-3
   Einhorn Daniel, 2003, Endocr Pract, V9, P237
   Ford ES, 2008, ANN EPIDEMIOL, V18, P165, DOI 10.1016/j.annepidem.2007.10.009
   Gavin JR, 1997, DIABETES CARE, V20, P1183
   Grundy SM, 2006, DIABETES CARE, V29, P1689, DOI 10.2337/dc05-2307
   Grundy SM, 2004, ARTERIOSCL THROM VAS, V24, pE13, DOI 10.1161/01.ATV.0000111245.75752.C6
   Hosseinpanah F, 2013, INT J CARDIOL, V168, P369, DOI 10.1016/j.ijcard.2012.09.037
   Kokubo Y, 2008, HYPERTENS RES, V31, P2027, DOI 10.1291/hypres.31.2027
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178, DOI 10.4088/JCP.v69n0202
   Li WJ, 2008, CHINESE MED J-PEKING, V121, P1532, DOI 10.1097/00029330-200808020-00006
   López-García E, 2003, INT J OBESITY, V27, P701, DOI 10.1038/sj.ijo.0802275
   Marijnissen RM, 2013, J AFFECT DISORDERS, V151, P1138, DOI 10.1016/j.jad.2013.07.029
   Momenan AA, 2012, ARCH IRAN MED, V15, P279, DOI 012155/AIM.007
   Montazeri A, 2005, QUAL LIFE RES, V14, P875, DOI 10.1007/s11136-004-1014-5
   Nadeau K, 2011, J ADOLESCENT HEALTH, V49, P90, DOI 10.1016/j.jadohealth.2010.10.005
   Park SS, 2011, DIABETES RES CLIN PR, V91, P381, DOI 10.1016/j.diabres.2010.11.010
   Qiao Q, 2006, DIABETOLOGIA, V49, P2837, DOI 10.1007/s00125-006-0438-6
   Regitz-Zagrosek V, 2006, CLIN RES CARDIOL, V95, P136, DOI 10.1007/s00392-006-0351-5
   Regitz-Zagrosek V, 2007, GENDER MED, V4, pS162, DOI 10.1016/S1550-8579(07)80056-8
   Roriz-Cruz M, 2007, J AM GERIATR SOC, V55, P374, DOI 10.1111/j.1532-5415.2007.01068.x
   Sakurai T, 2010, GERONTOLOGY, V56, P141, DOI 10.1159/000246970
   Saris-Baglama R.N., 2007, QUALITY METRIC HLTH
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Unwin N, 2002, DIABETIC MED, V19, P708, DOI 10.1046/j.1464-5491.2002.00835.x
   Ware JE, 1998, J CLIN EPIDEMIOL, V51, P903, DOI 10.1016/S0895-4356(98)00081-X
NR 36
TC 7
Z9 7
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3071
EI 1464-5491
J9 DIABETIC MED
JI Diabetic Med.
PD JUL
PY 2014
VL 31
IS 7
BP 854
EP 861
DI 10.1111/dme.12443
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA AJ4DL
UT WOS:000337621100015
PM 24654736
DA 2025-06-11
ER

PT J
AU Kirakosyan, A
   Seymour, EM
   Kondoleon, N
   Gutierrez, E
   Wolforth, J
   Bolling, S
AF Kirakosyan, Ara
   Seymour, E. Mitchell
   Kondoleon, Nicholas
   Gutierrez, Enrique
   Wolforth, Janet
   Bolling, Steven
TI The intake of red raspberry fruit is inversely related to cardiac risk
   factors associated with metabolic syndrome
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Red raspberry; Zucker Fatty rat; Type 2 diabetes mellitus;
   Cardiometabolic risk; Cardioprotection
ID KEY ENZYMES RELEVANT; POSTPRANDIAL GLYCEMIA; DIASTOLIC DYSFUNCTION;
   ALPHA-GLUCOSIDASE; OXIDATIVE STRESS; HEART-FAILURE; IN-VITRO; DIET;
   ANTHOCYANINS; CONSUMPTION
AB The effect of red raspberry fruit (RSP) was assessed in obesity-prone, Zucker Fatty rats as a model of cardiometabolic risk. RSP reduced fasting triglycerides and fasting glucose but did not appear to affect fasting insulin, low-density lipoprotein, or body weight gain. RSP did significantly reduce heart rate relative to time-matched CON rats. Noteworthy, RSP reduced left ventricular enlargement and wall thickening as measured by echocardiography, without impacting ejection fraction. Cardiac tissue was also evaluated for relative gene expression of key genes impacted in non-insulin-dependent diabetes mellitus (NIDDM). RSP upregulated the expression of myocardial adiponectin receptor 1 and apolipoprotein E, which may impact plasma cholesterol and triglyceride homeostasis. The lipoprotein lipase (Lpl) gene was down-regulated. On the contrary, RSP did not alter PPAR and NF-kB-related mRNA in heart tissue, but did alter nicotinamide phosphoribosyltransferase (Nampt) mRNA. RSP intake impacted cardiometabolic pathophysiology in this model, and molecular mechanisms deserve further study.
C1 [Kirakosyan, Ara; Seymour, E. Mitchell; Kondoleon, Nicholas; Gutierrez, Enrique; Wolforth, Janet; Bolling, Steven] Univ Michigan, Cardiac Surg, Ann Arbor, MI 48109 USA.
   [Gutierrez, Enrique] Univ San Pablo CEU, Fac Farm, Madrid, Spain.
C3 University of Michigan System; University of Michigan; San Pablo CEU
   University
RP Kirakosyan, A (corresponding author), Univ Michigan, NCRC, 2800 Plymouth Rd,NCRC Bldg 26-241S, Ann Arbor, MI 48109 USA.
EM akirakos@umich.edu
OI Kirakosyan, Ara/0000-0002-6269-9801; Kondoleon,
   Nicholas/0000-0002-2940-0070
FU National Processed Raspberry Council (USA)
FX This study was supported by an unrestricted grant from the National
   Processed Raspberry Council (USA).
CR Alqurashi RM, 2016, AM J CLIN NUTR, V104, P1227, DOI 10.3945/ajcn.115.128728
   Alvarado JL, 2016, BIOMED RES INT, V2016, DOI 10.1155/2016/9070537
   Burton-Freeman BM, 2016, ADV NUTR, V7, P44, DOI 10.3945/an.115.009639
   Castro-Acosta ML, 2016, P NUTR SOC, V75, P342, DOI 10.1017/S0029665116000240
   Coe S, 2016, J NUTR SCI, V5, DOI 10.1017/jns.2016.11
   Giacco F, 2010, CIRC RES, V107, P1058, DOI 10.1161/CIRCRESAHA.110.223545
   Guo X, 2016, EUR J CLIN NUTR, V70, P1360, DOI 10.1038/ejcn.2016.142
   Imai S, 2009, CURR PHARM DESIGN, V15, P20, DOI 10.2174/138161209787185814
   Jean-Gilles D, 2012, J AGR FOOD CHEM, V60, P5755, DOI 10.1021/jf203456w
   Jia H, 2011, PHARMACOGN MAG, V7, P19, DOI 10.4103/0973-1296.75885
   Kirakosyan A, 2010, FOOD CHEM, V122, P78, DOI 10.1016/j.foodchem.2010.02.017
   Kirakosyan A, 2009, FOOD CHEM, V115, P20, DOI 10.1016/j.foodchem.2008.11.042
   Kwon YI, 2008, BIORESOURCE TECHNOL, V99, P2981, DOI 10.1016/j.biortech.2007.06.035
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   Mathew AV, 2015, J CARD FAIL, V21, P963, DOI 10.1016/j.cardfail.2015.10.003
   Melanson KJ, 2012, NUTR J, V11, DOI 10.1186/1475-2891-11-57
   Noratto G, 2016, FOOD FUNCT, V7, P4944, DOI [10.1039/c6fo01330a, 10.1039/C6FO01330A]
   Schmidt JS, 2012, FOOD CHEM, V135, P1692, DOI 10.1016/j.foodchem.2012.05.075
   Seymour EM, 2008, J GERONTOL A-BIOL, V63, P1034, DOI 10.1093/gerona/63.10.1034
   Seymour EM, 2006, J MOL CELL CARDIOL, V41, P661, DOI 10.1016/j.yjmcc.2006.07.012
   Seymour EM, 2013, J NUTR BIOCHEM, V24, P1580, DOI 10.1016/j.jnutbio.2013.01.008
   Suh JH, 2011, FOOD FUNCT, V2, P400, DOI 10.1039/c1fo10047e
   Sun DL, 2012, J GERIATR CARDIOL, V9, P123, DOI 10.3724/SP.J.1263.2012.01172
   Trinh BTD, 2016, J ETHNOPHARMACOL, V186, P189, DOI 10.1016/j.jep.2016.03.060
   van Raalte DH, 2004, PHARM RES-DORDR, V21, P1531, DOI 10.1023/B:PHAM.0000041444.06122.8d
   Vendrame S, 2016, ANTIOXIDANTS-BASEL, V5, DOI 10.3390/antiox5040034
   Vikramadithyan RK, 2005, J PHARMACOL EXP THER, V313, P586, DOI 10.1124/jpet.104.080259
   Villiger A, 2015, PHYTOMEDICINE, V22, P138, DOI 10.1016/j.phymed.2014.11.015
   Zhou YT, 2000, P NATL ACAD SCI USA, V97, P1784, DOI 10.1073/pnas.97.4.1784
NR 29
TC 22
Z9 27
U1 0
U2 16
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD FEB
PY 2018
VL 41
BP 83
EP 89
DI 10.1016/j.jff.2017.12.033
PG 7
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA GA5GH
UT WOS:000428360700011
DA 2025-06-11
ER

PT J
AU Guijarro, SF
   Pomarol-Clotet, E
   Muñoz, MCR
   García, CM
   López, EE
   Guijarro, RF
   Pérez, LC
   Cuadra, MAR
AF Fernandez Guijarro, Sara
   Pomarol-Clotet, Edith
   Rubio Munoz, Ma Carmen
   Miguel Garcia, Carolina
   Egea Lopez, Elena
   Fernandez Guijarro, Rebeca
   Castan Perez, Lidia
   Rigol Cuadra, Ma Assumpta
TI Effectiveness of a community-based nurse-led lifestyle-modification
   intervention for people with serious mental illness and metabolic
   syndrome
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE lifestyle; intervention; metabolic syndrome; nurse; serious mental
   illness
ID QUALITY-OF-LIFE; WEIGHT-LOSS; PHYSICAL HEALTH; MEDITERRANEAN DIET;
   ADULTS; PROGRAM; RISK; INDIVIDUALS; CONSUMERS; EXERCISE
AB The development of metabolic syndrome negatively affects the quality of life of people with serious mental illness. Experts agree on the need to evaluate the physical health of patients and intervene in modifiable risk factors, with emphasis on the promotion of healthy lifestyles. Interventions should include nutritional counselling and physical activity. This 24-week randomized trial evaluated the effects of a community-based nurse-led lifestyle-modification intervention in people with serious mental illness meeting metabolic syndrome criteria, and its impact on health-related quality of life and physical activity. Sixty-one participants from two community mental health centres were randomly assigned to the intervention or control group. The intervention consisted of weekly group sessions, with 20 min of theoretical content and 60 min of nurse-led physical activity. Postintervention results between groups showed no differences in weight, waist circumference, fasting glucose, and systolic blood pressure. Differences in body mass index, triglyceride concentrations, and diastolic blood pressure were found to be significant (P = 0.010, P = 0.038, and P = 0.017). Participants who performed the intervention reported an increase in physical activity, which did not occur in the control group (P = 0.035), and also reported better health status (P < 0.001). Our intervention showed positive effects reducing participants' cardiovascular and metabolic risks and improving their physical activity and quality of life. To our knowledge, this is the first clinical trial led and carried out by mental health nurses in community mental health centres which takes into account the effects of a lifestyle intervention on every metabolic syndrome criterion, health-related quality of life, and physical activity.
C1 [Fernandez Guijarro, Sara] Ramon & Cajal Hosp, Madrid, Spain.
   [Pomarol-Clotet, Edith] FIDMAG Hermanas Hosp Res Fdn, Barcelona, Spain.
   [Rubio Munoz, Ma Carmen] Bennito Menni Hlth Care Complex, St Boi De Llobregat, Spain.
   [Miguel Garcia, Carolina; Rigol Cuadra, Ma Assumpta] Univ Barcelona, Sch Nursing, Barcelona, Spain.
   [Egea Lopez, Elena] Murcia Hlth Serv, Murcia, Spain.
   [Castan Perez, Lidia] Univ Zaragoza, Sch Nursing Huesca, Zaragoza, Spain.
C3 Hospital Universitario Ramon y Cajal; University of Barcelona;
   University of Zaragoza
RP Guijarro, SF (corresponding author), Raman y Cajal Hosp, Ctr Salud Mental Barajas, Ave Gen 5, Madrid 28042, Spain.
EM s.fguijarro@hotmail.com
RI Fernández, Sara/AAH-1827-2019
OI fernandez guijarro, sara/0000-0001-7013-8636; Pomarol-Clotet,
   Edith/0000-0002-8159-8563
CR [Anonymous], 2014, PSYCH SCHIZ AD TREAT
   Bernardo M., 2014, RECOMMENDATIONS MONI
   Bobes J, 2008, REV PSIQUIATR SALUD, V1, P26, DOI 10.1016/S1888-9891(08)72513-8
   Bressington DT, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-87
   Bruins J, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0112276
   Brunero S, 2009, INT J MENT HEALTH NU, V18, P144, DOI 10.1111/j.1447-0349.2009.00595.x
   Cabassa LJ, 2010, PSYCHIAT SERV, V61, P774, DOI 10.1176/ps.2010.61.8.774
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Daumit GL, 2013, NEW ENGL J MED, V368, P1594, DOI 10.1056/NEJMoa1214530
   De Hert M, 2009, EUR PSYCHIAT, V24, P412, DOI 10.1016/j.eurpsy.2009.01.005
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   Guijarro SF, 2020, J AM PSYCHIAT NURSES, V26, P162, DOI 10.1177/1078390319826686
   Fernandez S., 2017, REV PRESENCIA, V13
   Fernández-Bergés D, 2012, REV ESP CARDIOL, V65, P241, DOI [10.1016/j.recesp.2011.10.015, 10.1016/j.rec.2011.10.017]
   Foguet Q., 2012, ATEN PRIM, V45, P141
   Forsberg KA, 2008, NORD J PSYCHIAT, V62, P486, DOI 10.1080/08039480801985179
   Gomez-Huelgas R, 2015, EUR J INTERN MED, V26, P317, DOI 10.1016/j.ejim.2015.04.007
   Green CA, 2015, AM J PSYCHIAT, V172, P71, DOI 10.1176/appi.ajp.2014.14020173
   Happell B, 2014, INT J NURS STUD, V51, P236, DOI 10.1016/j.ijnurstu.2013.06.004
   Happell B, 2013, J CLIN NURS, V22, P2286, DOI 10.1111/j.1365-2702.2012.04325.x
   Happell B, 2012, INT J MENT HEALTH NU, V21, P236, DOI 10.1111/j.1447-0349.2012.00816.x
   Hassapidou M, 2011, BMC PSYCHIATRY, V11, DOI 10.1186/1471-244X-11-31
   HEATHERTON TF, 1991, BRIT J ADDICT, V86, P1119
   Herdman M, 2001, Aten Primaria, V28, P425
   Joffre-Velazquez V. M., 2009, MED J GEN HOSP, V72, P41
   KUYKEN W, 1995, SOC SCI MED, V41, P1403, DOI 10.1016/0277-9536(95)00112-k
   Landaeta-Díaz L, 2013, EUR J PREV CARDIOL, V20, P555, DOI 10.1177/2047487312445000
   Lee PH, 2011, INT J BEHAV NUTR PHY, V8, DOI 10.1186/1479-5868-8-115
   Lieberman JA, 2005, NEW ENGL J MED, V353, P1209, DOI 10.1056/NEJMoa051688
   Ministry of Labour and Social Affairs, 2007, MOD CAR PEOPL SEV ME
   Mora-Rodriguez R, 2018, NUTR METAB CARDIOVAS, V28, P1267, DOI 10.1016/j.numecd.2018.08.004
   Mora-Rodriguez R, 2016, INT J SPORTS MED, V37, P274, DOI 10.1055/s-0035-1564259
   Nursing Care Advisory Committee, 2010, MAN PROC COMM MENT H
   Park T, 2011, INT J MENT HEALTH NU, V20, P428, DOI 10.1111/j.1447-0349.2011.00747.x
   Reynolds GP, 2010, PHARMACOL THERAPEUT, V125, P169, DOI 10.1016/j.pharmthera.2009.10.010
   Richards L, 2016, J PSYCHOSOC NURS MEN, V54, P46, DOI 10.3928/02793695-20151109-02
   Richardson Caroline R, 2005, J Psychiatr Pract, V11, P379, DOI 10.1097/00131746-200511000-00004
   Saboya PP, 2017, ARQ BRAS CARDIOL, V108, P60, DOI 10.5935/abc.20160186
   Schalock RL, 2016, AJIDD-AM J INTELLECT, V121, P1, DOI 10.1352/1944-7558-121.1.1
   Scheen AJ, 2007, DIABETES METAB, V33, P169, DOI 10.1016/j.diabet.2007.01.003
   TOLOZA S.C. MANTILLA., 2007, Rev. Iberoam. Fisioter. Kinesiol, V10, P48, DOI [DOI 10.1016/S1138-6045(07)73665-1, 10.1016/S1138-6045(07)73665-1]
   Vehí C, 2016, MED CLIN-BARCELONA, V147, P537, DOI 10.1016/j.medcli.2016.09.041
   Vera E. M., 2014, PRESENCIA, V10
   Verdugo MA, 2005, J INTELL DISABIL RES, V49, P707, DOI 10.1111/j.1365-2788.2005.00739.x
   Verhaeghe N, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-431
   Wang Q, 2017, INT J CARDIOL, V230, P461, DOI 10.1016/j.ijcard.2016.12.084
NR 46
TC 23
Z9 25
U1 0
U2 40
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD DEC
PY 2019
VL 28
IS 6
BP 1328
EP 1337
DI 10.1111/inm.12644
EA AUG 2019
PG 10
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA JM5QQ
UT WOS:000481363500001
PM 31411375
DA 2025-06-11
ER

PT J
AU Steel, JL
   Cheng, H
   Pathak, R
   Wang, YS
   Miceli, J
   Hecht, CL
   Haggerty, D
   Peddada, S
   Geller, DA
   Marsh, W
   Antoni, M
   Jones, R
   Kamarck, T
   Tsung, A
AF Steel, Jennifer L.
   Cheng, Hannah
   Pathak, Ritambhara
   Wang, Yisi
   Miceli, Jessica
   Hecht, Carol Lynn
   Haggerty, Denise
   Peddada, Shyamal
   Geller, David A.
   Marsh, Wallis
   Antoni, Michael
   Jones, Reyna
   Kamarck, Thomas
   Tsung, Allan
TI Psychosocial and behavioral pathways of metabolic syndrome in cancer
   caregivers
SO PSYCHO-ONCOLOGY
LA English
DT Article
DE cancer; cardiovascular disease; caregivers; depression; oncology; social
   support; stress; quality of life
ID CORONARY-HEART-DISEASE; PERCEIVED STRESS; ALCOHOL-CONSUMPTION;
   PHYSICAL-ACTIVITY; RISK; METAANALYSIS; QUALITY; HEALTH; SCALE; HOSTILITY
AB Objective Cancer caregivers are at increased risk for cardiovascular disease (CVD) and mortality. The aims of this study were to examine psychosocial and behavioral predictors of metabolic syndrome, an intermediate endpoint of CVD. Methods Cancer caregivers were administered a battery of questionnaires assessing sociodemographic characteristics, depressive symptoms, perceived stress, caregiver quality of life, sleep, physical activity, alcohol and tobacco use, social support, relationship quality, and loneliness. Metabolic syndrome was defined using the American Heart Association guidelines and the National Cholesterol Education Program's Adult Treatment Panel (ATP) III, which includes the presence of at least three of the following abnormalities: blood pressure, glucose, abdominal girth, high-density lipoprotein (HDL), and triglycerides. Results Of the 104 caregivers, 77% were female, 94% were Caucasian, and the mean age was 59.5 (SD = 12.8). Of the 104 caregivers, 35.6% reported depressive symptoms in the clinical range of the Center for Epidemiologic Studies-Depression (CES-D) and 69.2% reported Perceived Stress Scale scores at least one standard deviation above the general population norms. A total of 16.3% of caregivers currently used tobacco, 28.8% consumed alcohol, and 26.7% were overweight (BMI = 25-29.9) and 48.5% were obese (BMI >= 30). Forty-nine percent of the caregivers met the criteria for metabolic syndrome. After age, gender, and race were adjusted, the following remained as significant predictors of metabolic syndrome: low levels of caregiver quality of life (Odds Ratio (OR) = 1.067; 95% CI, 1.019-1.117; P = .006), high levels of hostility (OR = 1.142; 95% CI, 1.030-1.267; P = .012), and current alcohol use (OR = 4.193; 95% CI, 1.174-14.978; P = .027). Conclusion Development of interventions to reduce the risk of metabolic syndrome in cancer caregivers is recommended.
C1 [Steel, Jennifer L.; Cheng, Hannah; Pathak, Ritambhara; Wang, Yisi; Miceli, Jessica; Hecht, Carol Lynn; Haggerty, Denise; Geller, David A.; Marsh, Wallis; Jones, Reyna; Tsung, Allan] Univ Pittsburgh, Dept Surg, 497 Scaife Hall, Pittsburgh, PA 15213 USA.
   [Kamarck, Thomas] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15213 USA.
   [Steel, Jennifer L.] Univ Pittsburgh, Dept Psychiat, 3811 Ohara St, Pittsburgh, PA 15213 USA.
   [Peddada, Shyamal] Univ Pittsburgh, Sch Publ Hlth, Dept Biostat, Pittsburgh, PA 15213 USA.
   [Antoni, Michael] Univ Miami, Dept Psychol, Miami, FL USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh; University of Miami
RP Steel, JL (corresponding author), Univ Pittsburgh, Ctr Excellence Behav Med, 3459 Fifth Ave,Montefiore 7S, Pittsburgh, PA 15213 USA.; Steel, JL (corresponding author), Univ Pittsburgh, Surg Psychiat & Psychol, Sch Med, 3459 Fifth Ave,Montefiore 7S, Pittsburgh, PA 15213 USA.
EM steeljl@upmc.edu
RI Geller, David/AAV-8082-2020; Cheng, Hannah/JMR-2432-2023; Tsubata,
   Takeshi/AAI-7489-2021
OI Antoni, Michael/0000-0002-3971-0873; Wang, Yisi/0000-0003-1306-4444;
   Cheng, Hannah/0000-0001-8144-5340
FU NCI NIH HHS [R01CA196953, R01 CA196953] Funding Source: Medline
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   American Heart Association, 2014, MET SYNDR SYMPT DIAG
   Baik I, 2013, J NUTR, V143, P1618, DOI 10.3945/jn.113.175315
   Bauman EM, 2012, VIOLENCE AGAINST WOM, V18, P30, DOI 10.1177/1077801212436523
   Bevans M, 2012, JAMA-J AM MED ASSOC, V307, P398, DOI 10.1001/jama.2012.29
   Birditt KS, 2016, J GERONTOL B-PSYCHOL, V71, P775, DOI 10.1093/geronb/gbv023
   Brown EG, 2018, PSYCHOPHYSIOLOGY, V55, DOI 10.1111/psyp.13031
   Busch LY, 2017, PSYCHOL BULL, V143, P1378, DOI 10.1037/bul0000119
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1016/0165-1781(89)90047-4
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hunsley J, 2001, AM J FAM THER, V29, P325, DOI 10.1080/01926180152588734
   Iftikhar IH, 2015, ANN AM THORAC SOC, V12, P1364, DOI 10.1513/AnnalsATS.201504-190OC
   Ji JG, 2012, CIRCULATION, V125, P1742, DOI 10.1161/CIRCULATIONAHA.111.057018
   Kashani M, 2012, STRESS, V15, P45, DOI 10.3109/10253890.2011.578266
   Lee S, 2003, AM J PREV MED, V24, P113, DOI 10.1016/S0749-3797(02)00582-2
   Matsumoto C, 2014, J CARDIOPULM REHABIL, V34, P159, DOI 10.1097/HCR.0000000000000042
   National Alliance for Caregiving, CANC CAR US INT EP C
   O'Keefe JH, 2014, MAYO CLIN PROC, V89, P382, DOI 10.1016/j.mayocp.2013.11.005
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Richardson S, 2012, AM J CARDIOL, V110, P1711, DOI 10.1016/j.amjcard.2012.08.004
   Russell DW, 1996, J PERS ASSESS, V66, P20, DOI 10.1207/s15327752jpa6601_2
   SCHERWITZ L, 1991, PSYCHOSOM MED, V53, P36, DOI 10.1097/00006842-199101000-00004
   Schulz R, 1999, JAMA-J AM MED ASSOC, V282, P2215, DOI 10.1001/jama.282.23.2215
   Steptoe A, 2012, NAT REV CARDIOL, V9, P360, DOI 10.1038/nrcardio.2012.45
   Sun K, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047791
   Sun K, 2014, CLIN NUTR, V33, P596, DOI 10.1016/j.clnu.2013.10.003
   Tenk J, 2018, PSYCHONEUROENDOCRINO, V95, P63, DOI 10.1016/j.psyneuen.2018.05.014
   Tindle HA, 2009, CIRCULATION, V120, P656, DOI 10.1161/CIRCULATIONAHA.108.827642
   Valtorta NK, 2016, HEART, V102, P1009, DOI 10.1136/heartjnl-2015-308790
   van Ryn M, 2011, PSYCHO-ONCOLOGY, V20, P44, DOI 10.1002/pon.1703
   Weitzner MA, 1999, QUAL LIFE RES, V8, P55, DOI 10.1023/A:1026407010614
   Zhang DD, 2017, METABOLISM, V75, P36, DOI 10.1016/j.metabol.2017.08.001
NR 34
TC 16
Z9 17
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1057-9249
EI 1099-1611
J9 PSYCHO-ONCOLOGY
JI Psycho-Oncol.
PD AUG
PY 2019
VL 28
IS 8
BP 1735
EP 1742
DI 10.1002/pon.5147
PG 8
WC Oncology; Psychology; Psychology, Multidisciplinary; Social Sciences,
   Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Psychology; Biomedical Social Sciences
GA IM6KH
UT WOS:000478101300018
PM 31206896
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Pascoe, MC
   Thompson, DR
   Ski, CF
AF Pascoe, Michaela C.
   Thompson, David R.
   Ski, Chantal F.
TI Meditation and Endocrine Health and Wellbeing
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID CENTRAL-NERVOUS-SYSTEM; TRANSCENDENTAL-MEDITATION; DEFAULT-MODE;
   MINDFULNESS PRACTICE; METABOLIC SYNDROME; STRESS REDUCTION;
   THYROID-HORMONES; NETWORK ACTIVITY; LONG-TERM; CORTISOL
AB Meditation is a popular practice for reducing stress and improving mental health and wellbeing. Its effects are mediated largely by the endocrine system, including the hypothalamic-pituitary-adrenal axis, the hypothalamic-pituitary-thyroid axis, and the renin-angiotensin-aldosterone system, and energy homeostasis. The limited evidence available indicates that changes associated with endocrine function following meditation correspond with improvements in mental health. However, this field of study is hampered by a lack of consensus as to definition and types of meditation and the mixed quality of reported studies. Moreover, the exact mechanisms by which meditation operates remain unclear and more robust studies are required to explore this by delineating the target populations, forms, dosages, and modes of delivery of meditation, comparison groups, and health experiences and outcomes used.
C1 [Pascoe, Michaela C.] Victoria Univ, Inst Sport Exercise & Act Living, Melbourne, Vic, Australia.
   [Thompson, David R.; Ski, Chantal F.] Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia.
   [Thompson, David R.; Ski, Chantal F.] Queens Univ Belfast, Sch Nursing & Midwifery, Belfast, Antrim, North Ireland.
C3 Victoria University; University of Melbourne; Queens University Belfast
RP Pascoe, MC (corresponding author), Victoria Univ, Inst Sport Exercise & Act Living, Melbourne, Vic, Australia.
EM Michaela.pascoe@vu.edu.au
RI Thompson, David/HJY-8387-2023; Ski, Chantal/AAJ-6595-2020; Thompson,
   David/E-2431-2018
OI Ski, Chantal/0000-0003-1324-2933; Pascoe, Michaela/0000-0002-3831-5660;
   Thompson, David/0000-0001-8518-6307
CR [Anonymous], ANGIOTENSIN
   [Anonymous], J PHYS ACT HORM
   [Anonymous], INDIAN J TRADITION K
   Atlas SA, 2007, J MANAGE CARE PHARM, V13, pS9, DOI 10.18553/jmcp.2007.13.s8-b.9
   Azam MA, 2016, INT J PSYCHOPHYSIOL, V110, P66, DOI 10.1016/j.ijpsycho.2016.10.011
   Bernotiene E, 2006, ARTHRITIS RES THER, V8, DOI 10.1186/ar2004
   Black DS, 2017, CANCER-AM CANCER SOC, V123, P3088, DOI 10.1002/cncr.30698
   Brand S, 2012, NEUROPSYCHOBIOLOGY, V65, P109, DOI 10.1159/000330362
   Bränström R, 2013, PSYCHOSOMATICS, V54, P158, DOI 10.1016/j.psym.2012.04.007
   Broyd SJ, 2009, NEUROSCI BIOBEHAV R, V33, P279, DOI 10.1016/j.neubiorev.2008.09.002
   Cahn BR, 2006, PSYCHOL BULL, V132, P180, DOI 10.1037/0033-2909.132.2.180
   Carlson LE, 2007, BRAIN BEHAV IMMUN, V21, P1038, DOI 10.1016/j.bbi.2007.04.002
   Chaiopanont Sompong, 2008, Journal of the Medical Association of Thailand, V91, P93
   Chatterjee S, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/240581
   Chrousos GP, 2009, NAT REV ENDOCRINOL, V5, P374, DOI 10.1038/nrendo.2009.106
   Everly G.J., 2013, A clinical guide to the treatment of the human stress response, V3rd, DOI DOI 10.1007/978-1-4614-5538-7
   Fan YX, 2014, STRESS HEALTH, V30, P65, DOI 10.1002/smi.2497
   Fox KCR, 2016, NEUROSCI BIOBEHAV R, V65, P208, DOI 10.1016/j.neubiorev.2016.03.021
   Fox KCR, 2014, NEUROSCI BIOBEHAV R, V43, P48, DOI 10.1016/j.neubiorev.2014.03.016
   Garrison KA, 2015, COGN AFFECT BEHAV NE, V15, P712, DOI 10.3758/s13415-015-0358-3
   Glaser R, 2005, NAT REV IMMUNOL, V5, P243, DOI 10.1038/nri1571
   Greicius MD, 2009, CEREB CORTEX, V19, P72, DOI 10.1093/cercor/bhn059
   Häfner S, 2012, PSYCHONEUROENDOCRINO, V37, P230, DOI 10.1016/j.psyneuen.2011.06.007
   Hamilton JP, 2011, BIOL PSYCHIAT, V70, P327, DOI 10.1016/j.biopsych.2011.02.003
   Harinath K, 2004, J ALTERN COMPLEM MED, V10, P261, DOI 10.1089/107555304323062257
   Hoge EA, 2018, PSYCHIAT RES, V262, P328, DOI 10.1016/j.psychres.2017.01.006
   Iwata M, 2013, BRAIN BEHAV IMMUN, V31, P105, DOI 10.1016/j.bbi.2012.12.008
   Jayadevappa R, 2007, ETHNIC DIS, V17, P72
   JEVNING R, 1978, HORM BEHAV, V10, P54, DOI 10.1016/0018-506X(78)90024-7
   JEVNING R, 1992, NEUROSCI BIOBEHAV R, V16, P415, DOI 10.1016/S0149-7634(05)80210-6
   Kikuchi M, 2005, PROG NEURO-PSYCHOPH, V29, P77, DOI 10.1016/j.pnpbp.2004.10.008
   Kinlein SA, 2015, FRONT PSYCHIATRY, V6, DOI 10.3389/fpsyt.2015.00031
   KROTKIEWSKI M, 1984, ACTA MED SCAND, V216, P269
   Lazarus R. S., 1984, Stress, appraisal, and coping, DOI [10.1007/978-3-030-39903-0_215, DOI 10.1007/978-1-4419-1005-9_215]
   Levine GN, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.117.002218
   MacLean CRK, 1997, PSYCHONEUROENDOCRINO, V22, P277, DOI 10.1016/S0306-4530(97)00003-6
   Malarkey WB, 2013, BRAIN BEHAV IMMUN, V27, P145, DOI 10.1016/j.bbi.2012.10.009
   Manzaneque JM, 2011, STRESS HEALTH, V27, P216, DOI 10.1002/smi.1334
   Marchand WR, 2014, WORLD J RADIOL, V6, P471, DOI 10.4329/wjr.v6.i7.471
   MICHAELS RR, 1979, PSYCHOSOM MED, V41, P50, DOI 10.1097/00006842-197902000-00006
   Miller DB, 2002, METABOLISM, V51, P5, DOI 10.1053/meta.2002.33184
   Nilakanthan Savitri, 2016, J Complement Integr Med, V13, P189, DOI 10.1515/jcim-2014-0079
   Oken BS, 2015, BEHAV BRAIN RES, V282, P144, DOI 10.1016/j.bbr.2014.12.047
   Ortiga-Carvalho TM, 2016, COMPR PHYSIOL, V6, P1387, DOI 10.1002/cphy.c150027
   Pascoe MC, 2017, PSYCHONEUROENDOCRINO, V86, P152, DOI 10.1016/j.psyneuen.2017.08.008
   Pascoe MC, 2017, J PSYCHIATR RES, V95, P156, DOI 10.1016/j.jpsychires.2017.08.004
   Pascoe MC, 2011, INT J STROKE, V6, P128, DOI 10.1111/j.1747-4949.2010.00565.x
   Paul-Labrador M, 2006, ARCH INTERN MED, V166, P1218, DOI 10.1001/archinte.166.11.1218
   Raffone A, 2009, PROG BRAIN RES, V176, P161, DOI 10.1016/S0079-6123(09)17620-3
   Raffone A, 2010, COGN PROCESS, V11, P1, DOI 10.1007/s10339-009-0354-z
   Ranabir Salam, 2011, Indian J Endocrinol Metab, V15 Suppl 3, pS188, DOI [10.4103/2230-8210.77573, 10.4103/2230-8210.84862]
   Rosen ED, 2006, NATURE, V444, P847, DOI 10.1038/nature05483
   Salim S, 2012, ADV PROTEIN CHEM STR, V88, P1, DOI 10.1016/B978-0-12-398314-5.00001-5
   Sapolsky RM, 2000, ENDOCR REV, V21, P55, DOI 10.1210/er.21.1.55
   Schwartz MW, 2000, NATURE, V404, P661, DOI 10.1038/35007534
   Silverman MN, 2012, ANN NY ACAD SCI, V1261, P55, DOI 10.1111/j.1749-6632.2012.06633.x
   Simsch C, 2002, INT J SPORTS MED, V23, P422, DOI 10.1055/s-2002-33738
   Sivasankaran S, 2006, CLIN CARDIOL, V29, P393, DOI 10.1002/clc.4960290905
   Stipcevic T, 2008, COLLEGIUM ANTROPOL, V32, P973
   Tang YY, 2015, NAT REV NEUROSCI, V16, P213, DOI 10.1038/nrn3916
   Travis F, 2010, CONSCIOUS COGN, V19, P1110, DOI 10.1016/j.concog.2010.01.007
   Vaccarino V, 2013, PSYCHOSOM MED, V75, P591, DOI 10.1097/PSY.0b013e31829ac4f4
   Vandana B, 2011, EVID-BASED COMPL ALT, V2011, P1, DOI 10.1155/2011/379645
   Ventriglio A, 2015, CURR PHARM DESIGN, V21, P1379, DOI 10.2174/1381612821666150105121244
   Walsh R, 2006, AM PSYCHOL, V61, P227, DOI 10.1037/0003-066X.61.3.227
   Walton K G, 1995, J Altern Complement Med, V1, P263, DOI 10.1089/acm.1995.1.263
   Walton K.G., 2003, Journal of Offender Rehabilitation, V36, P67
   Walton KG, 2004, ANN NY ACAD SCI, V1032, P211, DOI 10.1196/annals.1314.023
   WERNER OR, 1986, PSYCHOSOM MED, V48, P59, DOI 10.1097/00006842-198601000-00004
   Williams JMG, 2011, CONTEMP BUDDHISM, V12, P1, DOI 10.1080/14639947.2011.564811
   WOODS SC, 1985, AM J CLIN NUTR, V42, P1063, DOI 10.1093/ajcn/42.5.1063
   Zhou Y, 2010, J AFFECT DISORDERS, V121, P220, DOI 10.1016/j.jad.2009.05.029
NR 72
TC 17
Z9 20
U1 1
U2 39
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD JUL
PY 2020
VL 31
IS 7
BP 469
EP 477
DI 10.1016/j.tem.2020.01.012
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA LY2SP
UT WOS:000540373700001
PM 32037024
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Matta, J
   Hoertel, N
   Kesse-Guyot, E
   Plesz, M
   Wiernik, E
   Carette, C
   Czernichow, S
   Limosin, F
   Goldberg, M
   Zins, M
   Lemogne, C
AF Matta, Joane
   Hoertel, Nicolas
   Kesse-Guyot, Emmanuelle
   Plesz, Marie
   Wiernik, Emmanuel
   Carette, Claire
   Czernichow, Sebastien
   Limosin, Frederic
   Goldberg, Marcel
   Zins, Marie
   Lemogne, Cedric
TI Diet and physical activity in the association between depression and
   metabolic syndrome: Constances study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Metabolic syndrome; Diet; Physical activity
ID SYMPTOMS; BEHAVIOR; HEALTH; ADULTS; RISK; PREVALENCE; PATTERNS;
   DISORDER; REWARD
AB Background: The association between depression and the metabolic syndrome remains poorly understood. Diet and physical activity may partly explain this association.
   Methods: Baseline data on 64,861 subjects from the French population-based Constances cohort was analyzed. Depressive symptoms were determined with the Center of Epidemiologic Studies Depression (CES-D) scale. A CES-D score 19 combined with self-reported limitations related to depressive symptoms was used to define depression. The metabolic syndrome was defined according to the International Diabetes Federation criteria. Dietary patterns were determined with a food frequency questionnaire and a principal component analysis. Physical activity was measured with 3 questions resulting in a composite 6-point scale. Associations between depression and the metabolic syndrome were estimated through logistic regression and path analysis.
   Results: The odds-ratios (95% confidence interval) for the association between depression and the metabolic syndrome, adjusting for age, sex, education and income, was 1.75 (1.57-1.96). The path analysis showed that 23% of this association was explained by diet and physical activity, 67% being attributed to physical activity.
   Limitations: The cross-sectional nature of the analyses warrants the results to be confirmed by longitudinal analyses.
   Conclusion: Diet and physical activity might partially explain the association between depressive symptoms and metabolic syndrome but other factors (e.g. inflammatory factors) are involved.
C1 [Matta, Joane; Hoertel, Nicolas; Czernichow, Sebastien; Limosin, Frederic; Lemogne, Cedric] Univ Paris 05, Sorbonne Paris Cite, Fac Med, 102 Rue Sante, F-74014 Paris, France.
   [Matta, Joane; Hoertel, Nicolas; Limosin, Frederic; Lemogne, Cedric] Hop Univ Paris Ouest, AP HP, Serv Psychiat Adulte & Sujet Age, Paris, France.
   [Matta, Joane; Hoertel, Nicolas; Limosin, Frederic; Lemogne, Cedric] Inserm, Ctr Psychiat & Neurosci, U894, Paris, France.
   [Kesse-Guyot, Emmanuelle] Univ Paris 05, U1153, Inra, Cnam,Inserm, Paris, France.
   [Kesse-Guyot, Emmanuelle] Univ Paris 07, U1153, Inra, Cnam,Inserm, Paris, France.
   [Kesse-Guyot, Emmanuelle] Univ Paris 13, U1153, Inra, Cnam,Inserm, Paris, France.
   [Plesz, Marie] CNRS, Ctr Maurice Halbwachs UMR8097, EHESS, ENS,INRA, Paris, France.
   [Wiernik, Emmanuel; Goldberg, Marcel; Zins, Marie] Inserm, Populat Based Epidemiol Cohorts Unit, UMS 011, Villejuif, France.
   [Carette, Claire; Czernichow, Sebastien] Hop Europeen Georges Pompidou, Serv Nutr, Paris, France.
C3 Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP);
   Universite Paris Cite; Hopital Universitaire Europeen Georges-Pompidou -
   APHP; Universite Paris Cite; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Institut National de la Sante et de la
   Recherche Medicale (Inserm); heSam Universite; Conservatoire National
   Arts & Metiers (CNAM); Universite Paris Cite; INRAE; Universite Paris
   Cite; INRAE; heSam Universite; Conservatoire National Arts & Metiers
   (CNAM); Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite Paris 13; Universite Paris Cite; INRAE; Institut
   National de la Sante et de la Recherche Medicale (Inserm); heSam
   Universite; Conservatoire National Arts & Metiers (CNAM); Universite
   PSL; Ecole Normale Superieure (ENS); Centre National de la Recherche
   Scientifique (CNRS); INRAE; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Paris Cite; Assistance Publique
   Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire
   Europeen Georges-Pompidou - APHP
RP Matta, J (corresponding author), Univ Paris 05, Sorbonne Paris Cite, Fac Med, 102 Rue Sante, F-74014 Paris, France.
EM joane.matta@inserm.fr
RI Zins, Marie/AAX-6551-2021; Kesse-Guyot, Emmanuelle/F-2692-2017; Lemogne,
   Cédric/Q-6091-2019; Hoertel, Nicolas/H-9457-2015; Goldberg,
   Marcel/I-7834-2012; Wiernik, Emmanuel/AAD-5519-2019
OI Plessz, Marie/0000-0001-7026-6224; Goldberg, Marcel/0000-0002-6161-5880;
   Carette, Claire/0000-0002-8175-0369; Wiernik,
   Emmanuel/0000-0001-8046-7919
FU ANR [ANR-11-INBS0002]; MSD; AstraZeneca; Lundbeck; IReSP
   [LEMOGNE-AAP16-PREV-13]
FX The Constances Cohort benefits from a grant from ANR (ANR-11-INBS0002).
   Constances is also partly funded by MSD, AstraZeneca and Lundbeck. The
   present analyses were funded by the IReSP(LEMOGNE-AAP16-PREV-13).
CR Adjibade M, 2017, J NUTR, V147, P879, DOI 10.3945/jn.116.245167
   Barzi F, 2006, EUR J EPIDEMIOL, V21, P15, DOI 10.1007/s10654-005-5086-5
   Blanco C, 2018, J CLIN PSYCHIAT, V79, DOI 10.4088/JCP.18m12174
   Braden A, 2018, APPETITE
   Brug J, 2017, INT J BEHAV NUTR PHY, V14, DOI [10.1186/s12966-017-0609-5c, 10.1186/s12966-017-0609-5]
   Cédric L, 2017, J PSYCHOSOM RES, V97, P142, DOI 10.1016/j.jpsychores.2017.03.220
   Collin C, 2016, PREV MED, V91, P335, DOI 10.1016/j.ypmed.2016.09.001
   Dinan TG, 2015, CURR OPIN CLIN NUTR, V18, P552, DOI 10.1097/MCO.0000000000000221
   Ford ES, 2005, DIABETES CARE, V28, P2745, DOI 10.2337/diacare.28.11.2745
   Furihata R, 2018, J AFFECT DISORD
   Goldberg M, 2016, OCCUP ENV MED OEMED
   Hughes MM, 2016, INT J NEUROPSYCHOPH, V19, DOI 10.1093/ijnp/pyw001
   Kilian R, 2006, ACTA PSYCHIAT SCAND, V114, P242, DOI 10.1111/j.1600-0447.2006.00850.x
   Kuk JL, 2010, DIABETES CARE, V33, P2457, DOI 10.2337/dc10-0942
   Lamb KE, 2017, PUBLIC HEALTH NUTR, V20, P965, DOI [10.1017/S1368980016002986, 10.1017/s1368980016002986]
   Le Port A, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051593
   Lemogne C, 2017, CIRC-CARDIOVASC QUAL, V10, DOI 10.1161/CIRCOUTCOMES.116.002767
   Liu Ying, 2017, Prev Med Rep, V7, P193, DOI 10.1016/j.pmedr.2017.06.010
   Liu Y, 2017, J AFFECT DISORDERS, V217, P190, DOI 10.1016/j.jad.2017.04.009
   Lutsey PL, 2008, CIRCULATION, V117, P754, DOI 10.1161/CIRCULATIONAHA.107.716159
   Marazziti D, 2014, CNS SPECTRUMS, V19, P293, DOI 10.1017/S1092852913000667
   Melchior M, 2017, INTERGENERATIONAL SO
   Morin AJS, 2011, REV EPIDEMIOL SANTE, V59, P327, DOI 10.1016/j.respe.2011.03.061
   Muthen B. O., 1998, MPLUS USERS GUIDE
   Nabi H, 2011, HYPERTENSION, V57, P710, DOI 10.1161/HYPERTENSIONAHA.110.164061
   Ngo AD, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-681
   Paolucci EM, 2018, BIOL PSYCHOL, V133, P79, DOI 10.1016/j.biopsycho.2018.01.015
   Peltzer K, 2018, ASIAN J PSYCHIATR, V33, P52, DOI 10.1016/j.ajp.2018.03.017
   Plessz M, 2016, Bull Depidemiologie Hebd, V2016, P660
   Quirk SE, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-175
   Rose J. S, 2000, CONTRASTS MULTIPLE M, P155
   Ruiz F, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-3439-5
   Sanchez-Villegas A, 2013, BMC MED, V11, DOI [10.1186/1741-7015-11-3, 10.1186/1741-7015-11-208]
   Schuch F, 2017, J AFFECT DISORDERS, V210, P139, DOI 10.1016/j.jad.2016.10.050
   Simmons WK, 2016, AM J PSYCHIAT, V173, P418, DOI 10.1176/appi.ajp.2015.15020162
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Stage FK, 2004, J EDUC RES, V98, P5, DOI 10.3200/JOER.98.1.5-13
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vulser H, 2016, ACTA PSYCHIAT SCAND, V134, P150, DOI 10.1111/acps.12595
   Vulser H, 2018, J CLIN PSYCHIAT, V79, DOI 10.4088/JCP.17m12003
   Weltens N, 2014, NEUROGASTROENT MOTIL, V26, P303, DOI 10.1111/nmo.12309
   Wiernik E, 2018, INT J CARDIOL, V262, P99, DOI 10.1016/j.ijcard.2018.02.033
   Wiernik E, 2013, HYPERTENSION, V61, P571, DOI 10.1161/HYPERTENSIONAHA.111.00302
   Yang Jong-Eun, 2017, J Phys Ther Sci, V29, P2157, DOI 10.1589/jpts.29.2157
   Zhu B, 2015, J EPIDEMIOL, V25, P332, DOI 10.2188/jea.JE20140131
   Zins M, 2015, EUR J EPIDEMIOL, V30, P1317, DOI 10.1007/s10654-015-0096-4
NR 46
TC 43
Z9 47
U1 0
U2 85
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD FEB 1
PY 2019
VL 244
BP 25
EP 32
DI 10.1016/j.jad.2018.09.072
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA GZ2QZ
UT WOS:000449234400005
PM 30296663
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Daneshzad, E
   Keshavarz, SA
   Qorbani, M
   Larijani, B
   Azadbakht, L
AF Daneshzad, Elnaz
   Keshavarz, Seyed-Ali
   Qorbani, Mostafa
   Larijani, Bagher
   Azadbakht, Leila
TI Association between a low-carbohydrate diet and sleep status,
   depression, anxiety, and stress score
SO JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
LA English
DT Article
DE low-carbohydrate diet; dietary pattern; diabetes; depression; anxiety;
   sleep
ID METABOLIC SYNDROME; WEIGHT-LOSS; RISK; PATTERN; BEHAVIOR; PREVALENCE;
   ADHERENCE; SYMPTOMS; QUALITY
AB BACKGROUND Dietary intakes, especially carbohydrates, play an important role in blood glucose control in patients with diabetes. It is suggested that carbohydrate amounts may be effective in diabetes complications. This study aimed to reveal the association of low-carbohydrate diet (LCD) and sleep and mental status among patients with diabetes.
   METHODS This cross-sectional study was conducted among 265 women with type 2 diabetes. Anthropometric measures, as well as biochemical tests, were recorded. Dietary intakes were recorded using a validated food-frequency-questionnaire to calculate LCD score. To assess mental disorders and sleep quality, the Depression, Anxiety and Stress Scale and the Pittsburgh Sleep Quality Index were used respectively.
   RESULTS Patients in the highest LCD quartile were the ones with the lowest carbohydrate consumption. There was no significant association between cardiovascular risk factors and LCD score even after controlling confounder variables (P > 0.05). Subjects in the highest quartile of LCD score compared with those within the lowest quartile had a 69% lower risk of poor sleep after adjusting confounders. The odds of depressive symptoms were negatively related to the highest quartile of LCD score in the crude model and even after full-adjusted model (odds ratio: 0.42; 95% confidence interval: 0.17-1.01). Participants in the highest quartile of LCD score compared with those in the lowest quartile had a 73% lower risk of anxiety.
   CONCLUSION It seems that patients who consumed lower carbohydrate have better sleep status and are less involved with mental disorders. However, regarding the nature of the present study, well-designed cohort studies are suggested to be conducted in the future. (c) 2020 Society of Chemical Industry
C1 [Daneshzad, Elnaz; Azadbakht, Leila] Univ Tehran Med Sci, Dept Community Nutr, Sch Nutr Sci & Dietet, POB 1416643931, Tehran, Iran.
   [Keshavarz, Seyed-Ali] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran, Iran.
   [Qorbani, Mostafa] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.
   [Qorbani, Mostafa] Univ Tehran Med Sci, Chron Dis Res Ctr, Endocrinol & Metab Populat Sci Inst, Tehran, Iran.
   [Larijani, Bagher] Tehran Univ Med Sci Tehran, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
   [Azadbakht, Leila] Univ Tehran Med Sci, Diabet Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Alborz University of Medical Sciences; Tehran University of
   Medical Sciences; Tehran University of Medical Sciences; Tehran
   University of Medical Sciences
RP Azadbakht, L (corresponding author), Univ Tehran Med Sci, Dept Community Nutr, Sch Nutr Sci & Dietet, POB 1416643931, Tehran, Iran.
EM azadbakhtleila@gmail.com
RI larijani, Bagher/ABE-3315-2020; keshavarz, Seyed/AAD-3261-2019; Qorbani,
   Mostafa/M-8171-2017; Azadbakht, Leila/N-2801-2018; Daneshzad,
   Elnaz/O-3694-2018
OI Daneshzad, Elnaz/0000-0003-1400-8532; Larijani,
   Bagher/0000-0001-5386-7597
FU Tehran University of Medical Sciences [36923]
FX This study is supported by Tehran University of Medical Sciences (grant
   number: 36923).
CR Accurso A, 2008, NUTR METAB, V5, DOI 10.1186/1743-7075-5-9
   Afaghi A, 2008, NUTR NEUROSCI, V11, P146, DOI 10.1179/147683008X301540
   Ainsworth BE, 2000, MED SCI SPORT EXER, V32, pS498, DOI 10.1097/00005768-200009001-00009
   Akbaraly TN, 2009, BRIT J PSYCHIAT, V195, P408, DOI 10.1192/bjp.bp.108.058925
   Azadbakht L, 2009, J NUTR, V139, P335, DOI 10.3945/jn.108.096297
   Bercik P, 2011, GASTROENTEROLOGY, V141, P599, DOI 10.1053/j.gastro.2011.04.052
   Bot M, 2010, DIABETIC MED, V27, P1295, DOI 10.1111/j.1464-5491.2010.03119.x
   Budhiraja R, 2011, SLEEP, V34, P859, DOI 10.5665/SLEEP.1114
   Crispim CA, 2011, J CLIN SLEEP MED, V7, P659, DOI 10.5664/jcsm.1476
   Ein N, 2019, INT J OBESITY, V43, P1444, DOI 10.1038/s41366-018-0245-4
   Grandner MA, 2010, SLEEP MED, V11, P180, DOI 10.1016/j.sleep.2009.07.014
   Haagensen AMJ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0093821
   Halton TL, 2008, AM J CLIN NUTR, V87, P339, DOI 10.1093/ajcn/87.2.339
   Halton TL, 2006, NEW ENGL J MED, V355, P1991, DOI 10.1056/NEJMoa055317
   Halyburton AK, 2007, AM J CLIN NUTR, V86, P580, DOI 10.1093/ajcn/86.3.580
   Heijtza RD, 2011, P NATL ACAD SCI USA, V108, P3047, DOI 10.1073/pnas.1010529108
   HENRY RR, 1986, DIABETES, V35, P155, DOI 10.2337/diabetes.35.2.155
   Ho VW, 2011, CANCER RES, V71, P4484, DOI 10.1158/0008-5472.CAN-10-3973
   Hu T, 2015, NUTRIENTS, V7, P7978, DOI 10.3390/nu7095377
   Imaki Masahide, 2002, Journal of Physiological Anthropology and Applied Human Science, V21, P115, DOI 10.2114/jpa.21.115
   Kansanen M, 1998, CLIN PHYSIOL, V18, P377, DOI 10.1046/j.1365-2281.1998.00114.x
   Khayyatzadeh SS, 2019, PSYCHIAT RES, V272, P467, DOI 10.1016/j.psychres.2018.12.164
   Lieberman HR, 2005, BRAIN RES BULL, V66, P149, DOI 10.1016/j.brainresbull.2005.04.011
   Lucas M, 2014, BRAIN BEHAV IMMUN, V36, P46, DOI 10.1016/j.bbi.2013.09.014
   Luyster FS, 2011, DIABETES EDUCATOR, V37, P347, DOI 10.1177/0145721711400663
   Mirmiran P, 2017, INT J FOOD SCI NUTR, V68, P358, DOI 10.1080/09637486.2016.1242119
   Moghaddam JF, 2012, SLEEP BREATH, V16, P79, DOI 10.1007/s11325-010-0478-5
   Nanri A, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0118377
   Neufeld KM, 2011, NEUROGASTROENT MOTIL, V23, DOI 10.1111/j.1365-2982.2010.01620.x
   O' Neill Daniel F, 2003, Metab Syndr Relat Disord, V1, P291, DOI 10.1089/1540419031361345
   Rashidkhani B, 2013, PSYCHIAT RES, V210, P115, DOI 10.1016/j.psychres.2013.05.022
   Samani S., 2008, J Soc Sci Humanit Shiraz Univ, V26, P65
   Santos CJ, 2018, NUTR NEUROSCI, V21, P33, DOI 10.1080/1028415X.2016.1213529
   Saraf-Bank S, 2017, EUR J CLIN NUTR, V71, P425, DOI 10.1038/ejcn.2016.173
   Saris WHM, 2001, OBES RES, V9, p295S, DOI 10.1038/oby.2001.134
   Sheard NF, 2004, DIABETES CARE, V27, P2266, DOI 10.2337/diacare.27.9.2266
   Shi Z, 2005, INT J OBESITY, V32, P1835
   Shinkov A, 2018, POSTGRAD MED, V130, P251, DOI 10.1080/00325481.2018.1410054
   Spiegel K, 2004, ANN INTERN MED, V141, P846, DOI 10.7326/0003-4819-141-11-200412070-00008
   St-Onge MP, 2016, ADV NUTR, V7, P938, DOI 10.3945/an.116.012336
   Tokuchi Yoshio, 2016, Asia Pac Fam Med, V15, P4, DOI 10.1186/s12930-016-0029-8
   Westman EC, 2008, NUTR METAB, V5, DOI [10.1186/1743-7075-5-10, 10.1186/1743-7075-5-36]
NR 42
TC 42
Z9 44
U1 0
U2 41
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-5142
EI 1097-0010
J9 J SCI FOOD AGR
JI J. Sci. Food Agric.
PD MAY
PY 2020
VL 100
IS 7
BP 2946
EP 2952
DI 10.1002/jsfa.10322
EA FEB 2020
PG 7
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA LB9TC
UT WOS:000515197300001
PM 32031258
DA 2025-06-11
ER

PT J
AU Swaminathan, S
   Fonseca, VA
   Alam, MG
   Shah, SV
AF Swaminathan, Sundararaman
   Fonseca, Vivian A.
   Alam, Muhammad G.
   Shah, Sudhir V.
TI The role of iron in diabetes and its complications
SO DIABETES CARE
LA English
DT Review
ID CORONARY-HEART-DISEASE; TRANSFERRIN-BOUND IRON; C VIRUS-INFECTION; ACUTE
   MYOCARDIAL-INFARCTION; INSULIN-RESISTANCE SYNDROME; ELEVATED SERUM
   FERRITIN; IOWA WOMENS HEALTH; OXIDATIVE STRESS; THALASSEMIA MAJOR;
   CARDIOVASCULAR-DISEASE
C1 Univ Arkansas Med Sci, Div Nephrol, Little Rock, AR 72205 USA.
   Tulane Univ, Sch Med, Div Endocrinol, New Orleans, LA 70112 USA.
C3 University of Arkansas System; University of Arkansas Medical Sciences;
   Tulane University
RP Swaminathan, S (corresponding author), Univ Arkansas Med Sci, Div Nephrol, 4301 W Markham St,Slot 501, Little Rock, AR 72205 USA.
EM sswaminathan@uams.edu
RI Alam, Mohammad Gazi Shah/HLW-2112-2023
CR Acton RT, 2006, DIABETES CARE, V29, P2084, DOI 10.2337/dc05-1592
   Adams PC, 2005, NEW ENGL J MED, V352, P1769, DOI 10.1056/NEJMoa041534
   Agarwal R, 2004, KIDNEY INT, V65, P2279, DOI 10.1111/j.1523-1755.2004.00648.x
   Alcolado JC, 2002, DIABETIC MED, V19, P89, DOI 10.1046/j.1464-5491.2002.00675.x
   ALFREY AC, 1989, KIDNEY INT, V36, P753, DOI 10.1038/ki.1989.259
   Andrews NC, 1999, INT J BIOCHEM CELL B, V31, P991, DOI 10.1016/S1357-2725(99)00065-5
   Antonelli A, 2005, DIABETES CARE, V28, P2548, DOI 10.2337/diacare.28.10.2548
   ARBER N, 1994, DIGEST DIS SCI, V39, P2656, DOI 10.1007/BF02087705
   ASCHERIO A, 1994, CIRCULATION, V89, P969, DOI 10.1161/01.CIR.89.3.969
   Ascherio A, 2001, CIRCULATION, V103, P52
   BAER DM, 1994, CIRCULATION, V89, P2915, DOI 10.1161/01.CIR.89.6.2915
   BOFILL C, 1994, METABOLISM, V43, P614, DOI 10.1016/0026-0495(94)90204-6
   Borgna-Pignatti C, 2006, BLOOD, V107, P3733, DOI 10.1182/blood-2005-07-2933
   Boujaoude L, 2000, J Pediatr Gastroenterol Nutr, V31, P91, DOI 10.1097/00005176-200007000-00022
   Bozzini C, 2005, DIABETES CARE, V28, P2061, DOI 10.2337/diacare.28.8.2061
   BRITTENHAM GM, 1994, NEW ENGL J MED, V331, P567, DOI 10.1056/NEJM199409013310902
   CAMERON NE, 1995, J CLIN INVEST, V96, P1159, DOI 10.1172/JCI118104
   Cario H, 2003, EUR J PEDIATR, V162, P139, DOI 10.1007/s00431-002-1121-7
   CAVALLOPERIN P, 1995, METABOLISM, V44, P281, DOI 10.1016/0026-0495(95)90155-8
   Cavill I, 2003, NEPHROL DIAL TRANSPL, V18, P24, DOI 10.1093/ndt/gfg1088
   Chen XH, 2006, DIABETES CARE, V29, P1077, DOI 10.2337/dc06-0164
   Chern JPS, 2001, DIABETES CARE, V24, P850, DOI 10.2337/diacare.24.5.850
   Cooksey RC, 2004, ENDOCRINOLOGY, V145, P5305, DOI 10.1210/en.2004-0392
   Coppey LJ, 2001, DIABETES, V50, P1927, DOI 10.2337/diabetes.50.8.1927
   Corti MC, 1997, AM J CARDIOL, V79, P120, DOI 10.1016/S0002-9149(96)00697-2
   DANDONA P, 1983, ANN CLIN BIOCHEM, V20, P77, DOI 10.1177/000456328302000203
   Danesh J, 1999, CIRCULATION, V99, P852, DOI 10.1161/01.CIR.99.7.852
   Day SM, 2003, CIRCULATION, V107, P2601, DOI 10.1161/01.CIR.0000066910.02844.D0
   Derstine JL, 2003, AM J CLIN NUTR, V77, P56, DOI 10.1093/ajcn/77.1.56
   DMOCHOWSKI K, 1993, J CLIN ENDOCR METAB, V77, P478, DOI 10.1210/jc.77.2.478
   Drüeke T, 2002, CIRCULATION, V106, P2212, DOI 10.1161/01.CIR.0000035250.66458.67
   DYMOCK IW, 1972, AM J MED, V52, P203, DOI 10.1016/0002-9343(72)90070-8
   Fabio G, 2007, BLOOD, V109, P362, DOI 10.1182/blood-2006-04-016949
   Facchini FS, 2003, DIABETES, V52, P1204, DOI 10.2337/diabetes.52.5.1204
   Fernández-Real JM, 2005, CLIN CHEM, V51, P1201, DOI 10.1373/clinchem.2004.046847
   Fernández-Real JM, 2002, DIABETES, V51, P1000, DOI 10.2337/diabetes.51.4.1000
   Fernebro E, 2002, BMC CANCER, V2, DOI 10.1186/1471-2407-2-25
   Ford ES, 1999, DIABETES CARE, V22, P1978, DOI 10.2337/diacare.22.12.1978
   FRANKS AG, 1979, AM J MED SCI, V277, P163, DOI 10.1097/00000441-197903000-00004
   FRIDOVICH I, 1978, SCIENCE, V201, P875, DOI 10.1126/science.210504
   Fumeron F, 2006, DIABETES CARE, V29, P2090, DOI 10.2337/dc06-0093
   Gordeuk VR, 1998, BLOOD, V91, P2175, DOI 10.1182/blood.V91.6.2175.2175_2175_2179
   Gosriwatana I, 1999, ANAL BIOCHEM, V273, P212, DOI 10.1006/abio.1999.4216
   HA H, 1995, KIDNEY INT, V48, pS18
   HALLIWELL B, 1990, METHOD ENZYMOL, V186, P1
   HARA T, 1990, 11TH P INT C NEPHR J, pA442
   HARRIS DCH, 1994, CLIN EXP PHARMACOL P, V21, P73, DOI 10.1111/j.1440-1681.1994.tb02472.x
   HOWARD RL, 1991, KIDNEY INT, V40, P923, DOI 10.1038/ki.1991.295
   Inoue Y, 1997, AM J MED SCI, V314, P401, DOI 10.1097/00000441-199712000-00008
   Jehn M, 2004, DIABETES CARE, V27, P2422, DOI 10.2337/diacare.27.10.2422
   Jehn ML, 2007, AM J EPIDEMIOL, V165, P1047, DOI 10.1093/aje/kwk093
   Jiang R, 2004, JAMA-J AM MED ASSOC, V291, P711, DOI 10.1001/jama.291.6.711
   Jiang R, 2004, AM J CLIN NUTR, V79, P70
   JOHNSON WT, 1984, J NUTR, V114, P180, DOI 10.1093/jn/114.1.180
   Karthikeyan G, 2003, HUM MOL GENET, V12, P3331, DOI 10.1093/hmg/ddg349
   Kartikasari AER, 2004, ARTERIOSCL THROM VAS, V24, P2257, DOI 10.1161/01.ATV.0000147406.00871.b3
   Kiechl S, 1997, CIRCULATION, V96, P3300
   Knuiman MW, 2003, AM J EPIDEMIOL, V158, P144, DOI 10.1093/aje/kwg121
   Koo SW, 2003, J INVEST DERMATOL, V120, P871, DOI 10.1046/j.1523-1747.2003.12144.x
   Lao TT, 1997, DIABETES CARE, V20, P1368, DOI 10.2337/diacare.20.9.1368
   Lao TT, 2004, DIABETES CARE, V27, P650, DOI 10.2337/diacare.27.3.650
   Lee DH, 2006, DIABETES CARE, V29, P1090, DOI 10.2337/DC05-2471
   Lee DH, 2005, AM J CLIN NUTR, V81, P787, DOI 10.1093/ajcn/81.4.787
   Lee DH, 2004, DIABETOLOGIA, V47, P185, DOI 10.1007/s00125-003-1307-1
   Loebstein R, 1998, DIABETES CARE, V21, P1306, DOI 10.2337/diacare.21.8.1306
   MacCarthy PA, 2001, CIRCULATION, V104, P2967, DOI 10.1161/hc4901.100382
   McClain DA, 2006, DIABETOLOGIA, V49, P1661, DOI 10.1007/s00125-006-0200-0
   Mehta SH, 2000, ANN INTERN MED, V133, P592, DOI 10.7326/0003-4819-133-8-200010170-00009
   Mendler MH, 1999, GASTROENTEROLOGY, V117, P1155, DOI 10.1016/S0016-5085(99)70401-4
   MERKEL PA, 1988, NEW ENGL J MED, V318, P809, DOI 10.1056/NEJM198803313181303
   Miyajima H, 2002, BLOOD CELL MOL DIS, V29, P433, DOI 10.1006/bcmd.2002.0561
   Miyajima H, 2003, NEUROPATHOLOGY, V23, P345, DOI 10.1046/j.1440-1789.2003.00521.x
   NANKIVELL BJ, 1994, J AM SOC NEPHROL, V4, P1598
   NANKIVELL BJ, 1992, AM J KIDNEY DIS, V20, P580, DOI 10.1016/S0272-6386(12)70222-6
   NATH KA, 1994, KIDNEY INT, V45, pS111
   Nishiya K, 1996, Rinsho Byori, V44, P1201
   Njajou OT, 2002, MOL GENET METAB, V75, P290, DOI 10.1006/mgme.2002.3299
   Ozdemir Mehmet Akif, 2002, Pediatr Diabetes, V3, P205
   Papanikolaou G, 2004, NAT GENET, V36, P77, DOI 10.1038/ng1274
   Papanikolaou G, 2005, TOXICOL APPL PHARM, V202, P199, DOI 10.1016/j.taap.2004.06.021
   Platis Odysseas, 2004, Pediatr Endocrinol Rev, V2 Suppl 2, P279
   Ponka P, 1999, KIDNEY INT, V55, pS2, DOI 10.1046/j.1523-1755.1999.055Suppl.69002.x
   Qian MW, 1998, BIOCHEM BIOPH RES CO, V250, P385, DOI 10.1006/bbrc.1998.9326
   Rajpathak S, 2006, DIABETES CARE, V29, P1370, DOI 10.2337/dc06-0119
   Ramakrishnan U, 2002, AM J CLIN NUTR, V76, P1256, DOI 10.1093/ajcn/76.6.1256
   REDMON JB, 1993, DIABETES, V42, P544, DOI 10.2337/diabetes.42.4.544
   REMUZZI A, 1991, KIDNEY INT, V39, P647, DOI 10.1038/ki.1991.77
   Ristow M, 1998, DIABETES, V47, P851, DOI 10.2337/diabetes.47.5.851
   Ristow M, 2003, J CLIN INVEST, V112, P527, DOI 10.1172/JCI200318107
   Rund D, 2005, NEW ENGL J MED, V353, P1135, DOI 10.1056/NEJMra050436
   Salonen JT, 1998, AM J EPIDEMIOL, V148, P445
   SCHAFER AI, 1981, NEW ENGL J MED, V304, P319, DOI 10.1056/NEJM198102053040603
   Schulze MB, 2003, DIABETOLOGIA, V46, P1465, DOI 10.1007/s00125-003-1220-7
   Sempos CT, 2000, ANN EPIDEMIOL, V10, P441, DOI 10.1016/S1047-2797(00)00068-5
   Sheu WHH, 2003, CLIN ENDOCRINOL, V58, P380, DOI 10.1046/j.1365-2265.2003.01729.x
   SNOWDON DA, 1985, AM J PUBLIC HEALTH, V75, P507, DOI 10.2105/AJPH.75.5.507
   Soma J, 2000, J AM SOC NEPHROL, V11, P690, DOI 10.1681/ASN.V114690
   Song Y, 2004, DIABETES CARE, V27, P2108, DOI 10.2337/diacare.27.9.2108
   Strom TM, 1998, HUM MOL GENET, V7, P2021, DOI 10.1093/hmg/7.13.2021
   SULLIVAN JL, 1981, LANCET, V1, P1293
   Tiedge M, 1997, DIABETES, V46, P1733, DOI 10.2337/diabetes.46.11.1733
   Tuomainen TP, 1997, DIABETES CARE, V20, P426, DOI 10.2337/diacare.20.3.426
   Tuomainen TP, 1998, CIRCULATION, V97, P1461
   van Dam RM, 2002, DIABETES CARE, V25, P417, DOI 10.2337/diacare.25.3.417
   Van Der A DL, 2006, CIRCULATION, V113, P1942, DOI 10.1161/CIRCULATIONAHA.105.545350
   van der A DL, 2005, EUR HEART J, V26, P257, DOI 10.1093/eurheartj/ehi027
   Vantyghem MC, 2006, EUR J ENDOCRINOL, V154, P835, DOI 10.1530/eje.1.02152
   Walker ARP, 1999, BRIT J NUTR, V81, P427, DOI 10.1017/S000711459900077X
   Wilson JG, 2003, AM J MED SCI, V325, P332, DOI 10.1097/00000441-200306000-00004
   Witte DL, 1996, CLIN CHIM ACTA, V245, P139, DOI 10.1016/0009-8981(95)06212-2
   WOHAIEB SA, 1987, DIABETES, V36, P1014, DOI 10.2337/diabetes.36.9.1014
   YAN SD, 1994, J BIOL CHEM, V269, P9889
   YOUNG IS, 1995, FREE RADICAL BIO MED, V18, P833, DOI 10.1016/0891-5849(94)00202-U
   Zhang WJ, 2003, FREE RADICAL BIO MED, V34, P674, DOI 10.1016/S0891-5849(02)01375-8
   Zheng H, 2006, KIDNEY INT, V69, P679, DOI 10.1038/sj.ki.5000046
NR 115
TC 306
Z9 336
U1 2
U2 20
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD JUL
PY 2007
VL 30
IS 7
BP 1926
EP 1933
DI 10.2337/dc06-2625
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 186GZ
UT WOS:000247768400050
PM 17429063
OA Bronze
DA 2025-06-11
ER

PT J
AU Hu, MX
   Penninx, BWJH
   de Geus, EJC
   Lamers, F
   Kuan, DCH
   Wright, AGC
   Marsland, AL
   Muldoon, MF
   Manuck, SB
   Gianaros, PJ
AF Hu, Mandy X.
   Penninx, Brenda W. J. H.
   de Geus, Eco J. C.
   Lamers, Femke
   Kuan, Dora C. -H.
   Wright, Aidan G. C.
   Marsland, Anna L.
   Muldoon, Matthew F.
   Manuck, Stephen B.
   Gianaros, Peter J.
TI Associations of immunometabolic risk factors with symptoms of depression
   and anxiety: The role of cardiac vagal activity
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Depression; Anxiety; Inflammation; Metabolic syndrome; Autonomic nervous
   system; Cardiac vagal activity
ID HEART-RATE-VARIABILITY; AUTONOMIC NERVOUS-SYSTEM; C-REACTIVE PROTEIN;
   METABOLIC-SYNDROME; INFLAMMATORY MARKERS; CARDIOVASCULAR-DISEASE; MAJOR
   DEPRESSION; POPULATION; DISORDER; INVENTORY
AB Objectives: This study examined 1) the cross-sectional relationships between symptoms of depression/anxiety and immunometabolic risk factors, and 2) whether these relationships might be explained in part by cardiac vagal activity.
   Methods: Data were drawn from the Adult Health and Behavior registries (n=1785), comprised of community dwelling adults (52.8% women, aged 30-54). Depressive symptoms were measured with the Center for Epidemiological Studies Depression Scale (CES-D) and the Beck Depression Inventory-II (BDI-II), and anxious symptoms with the Trait Anxiety scale of the State-Trait Anxiety Inventory (STAI-T). Immunometabolic risk factors included fasting levels of triglycerides, high-density lipoproteins, glucose, and insulin, as well as blood pressure, waist circumference, body mass index, C-reactive protein, and interleukin-6. Measures of cardiac autonomic activity were high-and low-frequency indicators of heart rate variability (HRV), standard deviation of normal-to-normal R-R intervals, and the mean of absolute and successive differences in R-R intervals.
   Results: Higher BDI-II scores, in contrast to CES-D and STAI-T scores, were associated with increased immunometabolic risk and decreased HRV, especially HRV likely reflecting cardiac vagal activity. Decreased HRV was also associated with increased immunometabolic risk. Structural equation models indicated that BDI-II scores may relate to immunometabolic risk via cardiac vagal activity (indirect effect: beta=.012, p=.046) or to vagal activity via immunometabolic risk (indirect effect: beta=-.015, p=.021).
   Conclusions: Depressive symptoms, as measured by the BDI-II, but not anxious symptoms, were related to elevated levels of immunometabolic risk factors and low cardiac vagal activity. The latter may exhibit bidirectional influences on one another in a meditational framework. Future longitudinal, intervention, an nonhuman animal work is needed to elucidate the precise and mechanistic pathways linking depressive symptoms to immune, metabolic, and autonomic parameters of physiology that predispose to cardiovascular disease risk.
C1 [Hu, Mandy X.; Penninx, Brenda W. J. H.; Lamers, Femke] Vrije Univ Amsterdam Med Ctr, Amsterdam Publ Hlth Res Inst, Dept Psychiat, Amsterdam, Netherlands.
   [de Geus, Eco J. C.] Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands.
   [Kuan, Dora C. -H.; Wright, Aidan G. C.; Marsland, Anna L.; Manuck, Stephen B.; Gianaros, Peter J.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA.
   [Muldoon, Matthew F.] Univ Pittsburgh, Sch Med, Div Cardiol, Dept Med, Pittsburgh, PA 15260 USA.
C3 Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Vrije
   Universiteit Amsterdam; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth
   System of Higher Education (PCSHE); University of Pittsburgh
RP Hu, MX (corresponding author), Oldenaller 1, NL-1081 HJ Amsterdam, Netherlands.
EM m.hu@ggzingeest.nl
RI Lamers, Femke/G-5161-2012; Wright, Aidan/W-2821-2019; Stefanadis,
   Christodoulos/ABH-2232-2020; de Geus, Eco/M-9318-2015; Penninx, Brenda
   WJH/S-7627-2017
OI Stefanadis, Christodoulos/0000-0001-5974-6454; de Geus,
   Eco/0000-0001-6022-2666; Hu, Mandy Xian/0000-0002-4496-8772; Wright,
   Aidan/0000-0002-2369-0601; Lamers, Femke/0000-0003-4344-5766; Penninx,
   Brenda WJH/0000-0001-7779-9672
FU National Institutes of Health [PO1 HL040962, RO1 HL065137]
FX Preparation of this article was supported by the grants awarded to S.B.
   Manuck (PO1 HL040962 and RO1 HL065137) from the National Institutes of
   Health.
CR Allen JJB, 2007, BIOL PSYCHOL, V74, P243, DOI 10.1016/j.biopsycho.2006.08.005
   [Anonymous], 2008, Electronic Journal of Business Research Methods, DOI DOI 10.21427/D7CF7R
   Araújo F, 2006, INT J CARDIOL, V107, P333, DOI 10.1016/j.ijcard.2005.03.044
   Baune BT, 2012, PSYCHONEUROENDOCRINO, V37, P1521, DOI 10.1016/j.psyneuen.2012.02.006
   Baxter AJ, 2014, PSYCHOL MED, V44, P2363, DOI 10.1017/S0033291713003243
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   BECK AT, 1988, CLIN PSYCHOL REV, V8, P77, DOI 10.1016/0272-7358(88)90050-5
   Berntson GG, 1997, PSYCHOPHYSIOLOGY, V34, P623, DOI 10.1111/j.1469-8986.1997.tb02140.x
   Berntson GG, 2005, PSYCHOPHYSIOLOGY, V42, P246, DOI 10.1111/j.1469-8986.2005.00277.x
   Biasucci LM, 2004, CIRCULATION, V110, pE560, DOI 10.1161/01.CIR.0000148983.88334.80
   Bieling PJ, 1998, BEHAV RES THER, V36, P777, DOI 10.1016/S0005-7967(98)00023-0
   Bleil ME, 2008, PSYCHOSOM MED, V70, P328, DOI 10.1097/PSY.0b013e31816baefa
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   Butnoriene J, 2014, PSYCHONEUROENDOCRINO, V40, P269, DOI 10.1016/j.psyneuen.2013.11.002
   Carney RM, 2005, ARCH INTERN MED, V165, P1486, DOI 10.1001/archinte.165.13.1486
   Carney RM, 2005, PSYCHOSOM MED, V67, pS29, DOI 10.1097/01.psy.0000162254.61556.d5
   Carney RM, 2007, J PSYCHOSOM RES, V62, P463, DOI 10.1016/j.jpsychores.2006.12.004
   Carroll D, 2009, BIOL PSYCHIAT, V66, P91, DOI 10.1016/j.biopsych.2009.02.020
   Chalmers JA, 2014, FRONT PSYCHIATRY, V5, DOI 10.3389/fpsyt.2014.00080
   Chang HA, 2013, PSYCHIAT INVEST, V10, P326, DOI 10.4306/pi.2013.10.4.326
   Chang HA, 2012, ACTA NEUROPSYCHIATR, V24, P318, DOI 10.1111/j.1601-5215.2011.00647.x
   Christie IC, 2013, BEHAV RES METHODS, V45, P125, DOI 10.3758/s13428-012-0233-x
   Cooper TM, 2015, BRAIN BEHAV IMMUN, V49, P94, DOI 10.1016/j.bbi.2014.12.017
   Davidson J, 2005, J CLIN PSYCHOPHARM, V25, P480, DOI 10.1097/01.jcp.0000177547.28961.03
   Davidson KW, 2009, AM J CARDIOL, V103, P755, DOI 10.1016/j.amjcard.2008.11.035
   de Jonge P, 2010, NEUROSCI BIOBEHAV R, V35, P84, DOI 10.1016/j.neubiorev.2009.11.025
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   First M., 1996, Biometrics Research
   Fried EI, 2017, J AFFECT DISORDERS, V208, P191, DOI 10.1016/j.jad.2016.10.019
   Gasior JS, 2016, FRONT PHYSIOL, V7, DOI 10.3389/fphys.2016.00356
   Haapakoski R, 2015, BRAIN BEHAV IMMUN, V49, P206, DOI 10.1016/j.bbi.2015.06.001
   Haensel A, 2008, PSYCHONEUROENDOCRINO, V33, P1305, DOI 10.1016/j.psyneuen.2008.08.007
   HIRSCH JA, 1981, AM J PHYSIOL, V241, pH620, DOI 10.1152/ajpheart.1981.241.4.H620
   Hjemdahl P, 2002, CIRCULATION, V106, P2634, DOI 10.1161/01.CIR.0000041502.43564.79
   Hoge EA, 2009, DEPRESS ANXIETY, V26, P447, DOI 10.1002/da.20564
   Hu MX, 2017, AUTON NEUROSCI-BASIC, V208, P117, DOI 10.1016/j.autneu.2017.07.005
   Hu MX, 2016, PSYCHONEUROENDOCRINO, V71, P119, DOI 10.1016/j.psyneuen.2016.05.018
   Hu MX, 2018, PSYCHOSOM MED, V80, P475, DOI 10.1097/PSY.0000000000000589
   Kamphuis MH, 2007, EUR J CARDIOV PREV R, V14, P796, DOI 10.1097/HJR.0b013e32829c7d0c
   Kemp AH, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030777
   Kimura T, 2006, EUR J APPL PHYSIOL, V97, P542, DOI 10.1007/s00421-006-0207-8
   Kon H, 2006, INT HEART J, V47, P867, DOI 10.1536/ihj.47.867
   Koskinen T, 2009, DIABETIC MED, V26, P354, DOI 10.1111/j.1464-5491.2009.02686.x
   Kyrou I, 2009, CURR OPIN PHARMACOL, V9, P787, DOI 10.1016/j.coph.2009.08.007
   Lampert R, 2008, AM HEART J, V156, DOI 10.1016/j.ahj.2008.07.009
   Lepine Jean-Pierre, 2011, Neuropsychiatr Dis Treat, V7, P3, DOI 10.2147/NDT.S19617
   Liao DP, 1998, DIABETES CARE, V21, P2116, DOI 10.2337/diacare.21.12.2116
   Licht CMM, 2015, PSYCHOSOM MED, V77, P279, DOI 10.1097/PSY.0000000000000165
   Licht CMM, 2013, J CLIN ENDOCR METAB, V98, P2484, DOI 10.1210/jc.2012-3104
   Licht CMM, 2010, BIOL PSYCHIAT, V68, P861, DOI 10.1016/j.biopsych.2010.06.032
   Licht CMM, 2010, J CLIN ENDOCR METAB, V95, P2458, DOI 10.1210/jc.2009-2801
   Licht CMM, 2008, ARCH GEN PSYCHIAT, V65, P1358, DOI 10.1001/archpsyc.65.12.1358
   Lopez AD, 2006, LANCET, V367, P1747, DOI 10.1016/S0140-6736(06)68770-9
   Luppino FS, 2011, PSYCHOSOM MED, V73, P257, DOI 10.1097/PSY.0b013e31820a59c0
   Malik M, 1996, EUROPEAN HEART J, V17, P354, DOI [DOI 10.1093/0XF0RDJ0URNALS.EURHEARTJ.A014868), doi:10.1093/oxfordjournals.eurheartj.a014868]
   Manuck SB, 2010, PSYCHOSOM MED, V72, P35, DOI 10.1097/PSY.0b013e3181c484dc
   Marsland AL, 2007, PSYCHOSOM MED, V69, P709, DOI 10.1097/PSY.0b013e3181576118
   Marsland AL, 2010, METABOLISM, V59, P1801, DOI 10.1016/j.metabol.2010.05.015
   Messay B, 2012, BIOL MOOD ANXIETY DI, V2, DOI [10.1186/2045-5380-2-4, 10.1186/PREACCEPT-1461493759628561]
   Min KB, 2008, PACE, V31, P584, DOI 10.1111/j.1540-8159.2008.01045.x
   Musselman DL, 1998, ARCH GEN PSYCHIAT, V55, P580, DOI 10.1001/archpsyc.55.7.580
   MUTHEN LK, 2004, MPLUS VERSION 3 11
   Noordam R, 2016, PSYCHOL MED, V46, P1239, DOI 10.1017/S0033291715002779
   O'Donovan A, 2010, BRAIN BEHAV IMMUN, V24, P1074, DOI 10.1016/j.bbi.2010.03.003
   Orme C.M., 1988, Psychol Health, V2, P139, DOI [10.1080/08870448808400349, DOI 10.1080/08870448808400349]
   PAFFENBARGER RS, 1993, MED SCI SPORT EXER, V25, P60, DOI 10.1249/00005768-199301000-00010
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Penninx BWJH, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-129
   Pitsavos C, 2006, ATHEROSCLEROSIS, V185, P320, DOI 10.1016/j.atherosclerosis.2005.06.001
   Pongratz G, 2014, ARTHRITIS RES THER, V16, DOI 10.1186/s13075-014-0504-2
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Räikkönen K, 2007, DIABETES CARE, V30, P872, DOI 10.2337/dc06-1857
   Raison CL, 2006, TRENDS IMMUNOL, V27, P24, DOI 10.1016/j.it.2005.11.006
   del Paso GAR, 2013, PSYCHOPHYSIOLOGY, V50, P477, DOI 10.1111/psyp.12027
   Roest AM, 2010, J AM COLL CARDIOL, V56, P38, DOI 10.1016/j.jacc.2010.03.034
   Romijn JA, 2005, CURR OPIN CLIN NUTR, V8, P440, DOI 10.1097/01.mco.0000172586.09762.55
   Roohafza H, 2012, INT J ENDOCRINOL, V2012, DOI 10.1155/2012/380902
   Rugulies R, 2002, AM J PREV MED, V23, P51, DOI 10.1016/S0749-3797(02)00439-7
   Sheehan DV, 1997, EUR PSYCHIAT, V12, P232, DOI 10.1016/S0924-9338(97)83297-X
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Sloan RP, 2007, MOL MED, V13, P178, DOI 10.2119/2006-00112.Sloan
   Spielberger C. D., 1970, MANUAL STATE TRAIT A
   Spielberger C.D., 1970, STAI manual for the State-Trait Anxiety Inventory, DOI [10.1037/t06496-000, DOI 10.1037/T06496-000]
   Stein PK, 2007, DIABETIC MED, V24, P855, DOI 10.1111/j.1464-5491.2007.02163.x
   Stein PK, 2008, J AM GERIATR SOC, V56, P315, DOI 10.1111/j.1532-5415.2007.01564.x
   Tentolouris N, 2008, NEUROMOL MED, V10, P169, DOI 10.1007/s12017-008-8022-5
   Thayer Julian F, 2009, Cleve Clin J Med, V76 Suppl 2, pS23, DOI 10.3949/ccjm.76.s2.05
   Tracey KJ, 2002, NATURE, V420, P853, DOI 10.1038/nature01321
   Udupa K, 2011, ASIAN J PSYCHIATR, V4, P100, DOI 10.1016/j.ajp.2011.02.006
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
   van Roon AM, 2016, HYPERTENSION, V68, pE63, DOI 10.1161/HYPERTENSIONAHA.116.08053
   Vogelzangs N, 2010, J AFFECT DISORDERS, V125, P241, DOI 10.1016/j.jad.2010.02.112
   Vrijkotte TGM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0138302
   Watkins LL, 1998, PSYCHOSOM MED, V60, P498, DOI 10.1097/00006842-199807000-00018
   Wong PM, 2015, J CLIN ENDOCR METAB, V100, P4612, DOI 10.1210/jc.2015-2923
   Yi CX, 2010, BBA-MOL BASIS DIS, V1802, P416, DOI 10.1016/j.bbadis.2010.01.006
NR 97
TC 13
Z9 14
U1 1
U2 11
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD OCT
PY 2018
VL 73
BP 493
EP 503
DI 10.1016/j.bbi.2018.06.013
PG 11
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA GU6QO
UT WOS:000445440900048
PM 29920329
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Akinola, PS
   Tardif, I
   Leclerc, J
AF Akinola, Pelumi Samuel
   Tardif, Isabelle
   Leclerc, Jacinthe
TI Antipsychotic-Induced Metabolic Syndrome: A Review
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Review
DE antipsychotics; schizophrenia; metabolic syndrome; adverse events;
   adverse drug reaction
ID CLINICAL-PRACTICE GUIDELINES; SEVERE MENTAL-ILLNESS; WEIGHT-GAIN;
   2ND-GENERATION ANTIPSYCHOTICS; CARDIOVASCULAR-DISEASE;
   PHYSICAL-ACTIVITY; SCHIZOPHRENIA; MANAGEMENT; PREVENTION; DYSLIPIDEMIA
AB Schizophrenia, a serious psychiatric disorder, is among the top 10 global causes of disability and affects nearly 1% of the world population. Antipsychotics constitute the best treatment for patients with schizophrenia, however, this treatment class carries a high risk of metabolic syndrome, including lipid abnormalities. Indeed, the risk of metabolic syndrome would be increased in the population with schizophrenia compared to the general population. The objective is to summarize the prevalence, the mechanisms, and the potential treatments of antipsychotic-induced metabolic syndrome. This is a narrative review of the literature. We searched the electronic database Medline, accessed through PubMed, to find studies that investigated the prevalence and treatments of metabolic syndrome in the adult population using antipsychotics. The prevalence of metabolic syndrome in patients treated with antipsychotics ranges from 37% to 63%. Antipsychotic iatrogenic effects include weight gain/increased waist circumference, dyslipidemia, insulin resistance/type 2 diabetes, and hypertension. Clozapine and olanzapine are reported to precipitate the onset of metabolic syndrome features. In patients with metabolic syndrome, an antipsychotic with less metabolic side effects such as lurasidone, lumateperone, ziprasidone, and aripiprazole should be prioritized. Unlike medications, aerobic exercise and dietetic counseling were found to be efficient as the nonpharmacologic treatment of antipsychotic-induced metabolic syndrome. Few pharmacological treatments were proven effective against weight gain in this patient population. The risk of metabolic syndrome induced by antipsychotics should be early recognized and closely monitored. Primary and secondary prevention of metabolic syndrome or onset of its feature might help reduce the risk of death for patients using antipsychotics.
C1 [Akinola, Pelumi Samuel] Univ Manitoba, Coll Pharm, Rady Fac Hlth Sci, Winnipeg, MB, Canada.
   [Tardif, Isabelle] Univ Laval, Fac Med, Quebec City, PQ, Canada.
   [Leclerc, Jacinthe] Univ Laval, Fac Pharm, Quebec City, PQ, Canada.
   [Leclerc, Jacinthe] Univ Laval, Inst Univ Cardiol Pneumol Quebec, Ctr Rech, Quebec City, PQ, Canada.
   [Leclerc, Jacinthe] Univ Laval, Inst Univ Cardiol Pneumol Quebec, Ctr Rech, 2725 Chemin Sainte Foy,Local Y 3126, Quebec City, PQ G1V 4G5, Canada.
C3 University of Manitoba; Laval University; Laval University; Laval
   University; Laval University Hospital; Laval University; Laval
   University Hospital
RP Leclerc, J (corresponding author), Univ Laval, Inst Univ Cardiol Pneumol Quebec, Ctr Rech, 2725 Chemin Sainte Foy,Local Y 3126, Quebec City, PQ G1V 4G5, Canada.
EM jacinthe.leclerc@criucpq.ulaval.ca
RI Leclerc, Jacinthe/Q-7154-2019
OI Akinola, Pelumi Samuel/0000-0001-5326-7057
CR Abosi O, 2018, HORM MOL BIOL CLIN I, V36, DOI 10.1515/hmbci-2017-0065
   Agahi M, 2018, DIAB MET SYND CLIN R, V12, P9, DOI 10.1016/j.dsx.2017.08.004
   Andrade C, 2013, BIPOLAR DISORD, V15, P813, DOI 10.1111/bdi.12130
   [Anonymous], 2004, J CLIN PSYCHIAT, V65, P267
   Barabássy A, 2021, NEUROPSYCH DIS TREAT, V17, P957, DOI 10.2147/NDT.S301225
   Bernardo M, 2021, ADV THER, V38, P2491, DOI 10.1007/s12325-021-01689-8
   Bou Khalil Rami, 2012, Presse Med, V41, pe238, DOI 10.1016/j.lpm.2011.10.013
   Brouwer JMJL, 2021, BMC PSYCHIATRY, V21, DOI 10.1186/s12888-021-03162-w
   Cernea S, 2020, DRUGS, V80, P1763, DOI 10.1007/s40265-020-01393-x
   Chang SC, 2021, WORLD J PSYCHIATR, V11, P696, DOI 10.5498/wjp.v11.i10.696
   Citrome Leslie, 2012, Clin Schizophr Relat Psychoses, V6, P76, DOI 10.3371/CSRP.6.2.5
   Cooper SJ, 2016, J PSYCHOPHARMACOL, V30, P717, DOI 10.1177/0269881116645254
   Corponi F, 2019, EUR NEUROPSYCHOPHARM, V29, P971, DOI 10.1016/j.euroneuro.2019.06.008
   Correll CU, 2021, SCHIZOPHR RES, V228, P198, DOI 10.1016/j.schres.2020.12.006
   Correll CU, 2020, AM J PSYCHIAT, V177, P1168, DOI 10.1176/appi.ajp.2020.19121279
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   Hert M, 2012, NAT REV ENDOCRINOL, V8, P114, DOI 10.1038/nrendo.2011.156
   Edinoff Amber, 2020, Psychopharmacol Bull, V50, P32
   Edinoff Amber, 2020, Psychopharmacol Bull, V50, P83
   Erickson ZD, 2017, J GEN INTERN MED, V32, pS32, DOI 10.1007/s11606-016-3960-3
   Fagiolini A, 2020, ANN GEN PSYCHIATR, V19, DOI 10.1186/s12991-020-00305-3
   Fitzgerald I, 2022, EVID-BASED MENT HEAL, V25, P15, DOI 10.1136/ebmental-2021-300291
   Fleischhacker WW, 2014, SCHIZOPHRENIA BULL, V40, pS165, DOI 10.1093/schbul/sbu006
   Galletly C, 2016, AUST NZ J PSYCHIAT, V50, P410, DOI 10.1177/0004867416641195
   Goh KK, 2021, J PSYCHOPHARMACOL, V35, P221, DOI 10.1177/0269881120981392
   Han TS, 2016, JRSM CARDIOVASC DIS, V5, DOI 10.1177/2048004016633371
   health Niom, 2021, SCHIZOPHRENIA
   Herbsleb M, 2018, SCHIZOPHR RES, V197, P162, DOI 10.1016/j.schres.2018.02.020
   Hirsch L, 2017, DRUG SAFETY, V40, P771, DOI 10.1007/s40264-017-0543-0
   Houlden RL, 2018, CAN J DIABETES, V42, pS1, DOI 10.1016/j.jcjd.2017.10.001
   Howell S, 2019, HEART, V105, P1852, DOI 10.1136/heartjnl-2017-312107
   Ijaz S, 2018, BMC PSYCHIATRY, V18, DOI 10.1186/s12888-018-1848-y
   Jeon SW, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18102174
   Jiang WL, 2020, TRANSL PSYCHIAT, V10, DOI 10.1038/s41398-020-0785-y
   Kanagasundaram P, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.642403
   Keepers GA, 2020, AM J PSYCHIAT, V177, P868, DOI [10.1176/appi.ajp.2020.177901, 10.1176/appi.focus.18402]
   Lally J, 2013, J PSYCHOPHARMACOL, V27, P401, DOI 10.1177/0269881112472568
   Lan YL, 2012, ASIAN NURS RES, V6, P13, DOI 10.1016/j.anr.2012.02.003
   Lao KSJ, 2016, CNS DRUGS, V30, P1043, DOI 10.1007/s40263-016-0382-z
   Larsen JR, 2017, JAMA PSYCHIAT, V74, P719, DOI 10.1001/jamapsychiatry.2017.1220
   Lian JM, 2016, PHARMACOL RES, V106, P51, DOI 10.1016/j.phrs.2016.02.011
   Lieberman JA, 2016, BIOL PSYCHIAT, V79, P952, DOI 10.1016/j.biopsych.2015.08.026
   Maayan L, 2010, NEUROPSYCHOPHARMACOL, V35, P1520, DOI 10.1038/npp.2010.21
   Mamakou V, 2018, Psychiatriki, V29, P64, DOI 10.22365/jpsych.2018.291.64
   Marder SR, 2019, NEW ENGL J MED, V381, P1753, DOI 10.1056/NEJMra1808803
   Marteene W, 2019, EXPERT OPIN DRUG SAF, V18, P1149, DOI 10.1080/14740338.2019.1674809
   Martin WF, 2019, AM J PSYCHIAT, V176, P457, DOI 10.1176/appi.ajp.2018.18030280
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Nomura I, 2018, PSYCHIAT RES, V260, P41, DOI 10.1016/j.psychres.2017.11.033
   Nyboe L, 2019, PSYCHIAT RES, V281, DOI 10.1016/j.psychres.2019.112556
   Ojala K, 2008, J PSYCHOPHARMACOL, V22, P33, DOI 10.1177/0269881107077815
   Orsolini L, 2020, EXPERT OPIN DRUG SAF, V19, P981, DOI 10.1080/14740338.2020.1795126
   Pearson GJ, 2021, CAN J CARDIOL, V37, P1129, DOI 10.1016/j.cjca.2021.03.016
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Phan SV, 2016, INT J PSYCHIAT MED, V51, P211, DOI 10.1177/0091217416636601
   Pillinger T, 2020, LANCET PSYCHIAT, V7, P64, DOI 10.1016/S2215-0366(19)30416-X
   Potkin SG, 2020, J CLIN PSYCHIAT, V81, DOI 10.4088/JCP.19m12769
   Prestwood TR, 2021, BEHAV BRAIN RES, V402, DOI 10.1016/j.bbr.2020.113101
   Rabi DM, 2020, CAN J CARDIOL, V36, P596, DOI 10.1016/j.cjca.2020.02.086
   Reynolds GP, 2017, J PSYCHOPHARMACOL, V31, P1430, DOI 10.1177/0269881117722987
   Rojo LE, 2015, PHARMACOL RES, V101, P74, DOI 10.1016/j.phrs.2015.07.022
   Romain AJ, 2019, SCHIZOPHR RES, V210, P278, DOI 10.1016/j.schres.2018.12.021
   Ruppert J, 2018, EUR ARCH PSY CLIN N, V268, P719, DOI 10.1007/s00406-017-0858-y
   Shen H, 2018, PSYCHIAT RES, V262, P84, DOI 10.1016/j.psychres.2018.02.018
   Siskind D, 2021, SCHIZOPHRENIA BULL, V47, P948, DOI 10.1093/schbul/sbaa191
   Siskind D, 2019, DIABETES OBES METAB, V21, P293, DOI 10.1111/dom.13522
   Srisurapanont M, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-87285-w
   Stubbs B, 2018, EUR PSYCHIAT, V54, P124, DOI 10.1016/j.eurpsy.2018.07.004
   Swarup S., 2022, StatPearls Internet
   Taylor M, 2015, BRIT J PSYCHIAT, V206, P357, DOI 10.1192/bjp.bp.114.155945
   Tse L, 2014, INT CLIN PSYCHOPHARM, V29, P125, DOI 10.1097/YIC.0000000000000014
   Vallis TM., 2020, Canadian Adult Obesity Clinical Practice Guidelines: Effective Psychological and Behavioural Interventions in Obesity Management
   Vancampfort D, 2019, WORLD PSYCHIATRY, V18, P53, DOI 10.1002/wps.20614
   Vancampfort D, 2016, SCHIZOPHR RES, V170, P336, DOI 10.1016/j.schres.2016.01.001
   Vanover K., 2019, CNS Spectr, V24, P190, DOI [10.1017/S1092852919000245, DOI 10.1017/S1092852919000245]
   Vermeulen J, 2017, PSYCHOL MED, V47, P2217, DOI 10.1017/S0033291717000873
   Zheng W, 2017, J CLIN PSYCHOPHARM, V37, P341, DOI 10.1097/JCP.0000000000000598
   Zhuo CJ, 2021, J AFFECT DISORDERS, V295, P163, DOI 10.1016/j.jad.2021.08.023
NR 78
TC 13
Z9 14
U1 4
U2 29
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD AUG 1
PY 2023
VL 21
IS 6
BP 294
EP 305
DI 10.1089/met.2023.0003
EA JUN 2023
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA P4GN3
UT WOS:001014397800001
PM 37347965
DA 2025-06-11
ER

PT J
AU Renzaho, AMN
   Houng, B
   Oldroyd, J
   Nicholson, JM
   D'Esposito, F
   Oldenburg, B
AF Renzaho, Andre M. N.
   Houng, Brendan
   Oldroyd, John
   Nicholson, Jan M.
   D'Esposito, Fabrizio
   Oldenburg, Brian
TI Stressful life events and the onset of chronic diseases among Australian
   adults: findings from a longitudinal survey
SO EUROPEAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
ID AFRICAN-AMERICAN WOMEN; SOCIAL SUPPORT; BREAST-CANCER;
   PSYCHOLOGICAL-FACTORS; METABOLIC SYNDROME; HEART-DISEASE; JOB STRAIN;
   RISK; HEALTH; ASTHMA
AB Objectives: This article examines the link between stressful life events and illness by considering both onset and reoccurrence of chronic illnesses. Using longitudinal data, we estimate the extent to which life events increase the likelihood of depression or anxiety, type 2 diabetes, cancer, coronary heart disease, circulatory disease, asthma and emphysema among Australian adults aged epsilon 21 years. Methods: Longitudinal data were obtained from the nationally representative Household, Income and Labour Dynamics in Australia panel survey collected at waves 3 (2003), 7 (2007) and 9 (2009). Participants (N = 9222) answered life events questions relating to the preceding 12 months and chronic illnesses lasting (or expected to last for) 6 months. Weighted pooled and random effects logistic regressions were performed, controlling for confounders and previous illness, and also performed on subsamples delineated by reported illnesses in wave 3. Results: Work-related stress [odds ratio (OR) = 1.54, P < 0.001] was positively associated with the onset of depression or anxiety. Personal stress increased the likelihood of the onset of depression or anxiety (OR = 1.70, P < 0.001), type 2 diabetes (OR = 1.47, P < 0.05) and circulatory diseases (OR = 1.72, P < 0.05), while family-related stress increased the likelihood of the onset of heart (OR = 1.32, P < 0.01) and circulatory diseases (OR = 1.32, P < 0.05). Conclusions: Independent of personal characteristics and key health measures (body mass index, hypertension and disability), these findings suggest that work-related, personal and family-related stressful life events contribute to the development and/or course of chronic diseases.
C1 [Renzaho, Andre M. N.; Oldroyd, John; Oldenburg, Brian] Monash Univ, Sch Publ Hlth & Prevent Med, Int Publ Hlth Unit, Melbourne, Vic 3004, Australia.
   [Houng, Brendan] Univ Melbourne, Melbourne Inst Appl Econ & Social Res, Melbourne, Vic 3010, Australia.
   [Nicholson, Jan M.; D'Esposito, Fabrizio] Parenting Res Ctr, East Melbourne, Vic, Australia.
C3 Monash University; University of Melbourne
RP Renzaho, AMN (corresponding author), Monash Univ, Sch Publ Hlth & Prevent Med, Int Publ Hlth Unit, Level 3,Burnet Bldg,89 Commercial Rd, Melbourne, Vic 3004, Australia.
EM andre.renzaho@monash.edu
RI Renzaho, Andre/AAH-7679-2021; Houng, Brendan/P-3147-2015
OI RENZAHO, ANDRE/0000-0002-6844-0833; Oldenburg,
   Brian/0000-0002-7712-5413; Houng, Brendan/0000-0002-0858-7876; Oldroyd,
   John/0000-0002-2269-6294; Nicholson, Jan/0000-0002-0305-0017
FU ARC; Victorian Government Department of Education and Early Child
   Development; Australian Government Department of Families, Housing,
   Community Services and Indigenous Affairs (FaHCSIA)
FX A/Prof. Andre Renzaho is supported by an ARC Future Fellowship. Prof
   Nicholson and Dr D'Esposito were supported by funding from the Victorian
   Government Department of Education and Early Child Development. This
   article uses unit record data from the HILDA survey. The HILDA project
   was initiated and is funded by the Australian Government Department of
   Families, Housing, Community Services and Indigenous Affairs (FaHCSIA)
   and is managed by the Melbourne Institute of Applied Economic and Social
   Research (Melbourne Institute). The findings and views reported in this
   article, however, are those of the author and should not be attributed
   to either FaHCSIA or the Melbourne Institute.
CR Achat H, 2000, INT J EPIDEMIOL, V29, P622, DOI 10.1093/ije/29.4.622
   Adams P, 2003, J ECONOMETRICS, V112, P3, DOI 10.1016/S0304-4076(02)00145-8
   Arulampalam W, 2009, OXFORD B ECON STAT, V71, P659, DOI 10.1111/j.1468-0084.2009.00554.x
   Barry D, 2008, PREV MED, V47, P498, DOI 10.1016/j.ypmed.2008.08.006
   Bjorntorp P, 1997, NUTRITION, V13, P795, DOI 10.1016/S0899-9007(97)00191-3
   Cobb-Clark D., 2011, 5630 IZA
   Cosgrove M, 2004, OCCUP MED-OXFORD, V54, P250, DOI 10.1093/occmed/kqh047
   Cutrona CE, 2005, J ABNORM PSYCHOL, V114, P3, DOI 10.1037/0021-843X.114.1.3
   Dalton SO, 2002, EUR J CANCER, V38, P1313, DOI 10.1016/S0959-8049(02)00099-0
   EDWARDS JR, 1988, SOC SCI MED, V27, P1447, DOI 10.1016/0277-9536(88)90212-2
   Engström G, 2004, CEREBROVASC DIS, V18, P318, DOI 10.1159/000080770
   Engström M, 2006, ARTERIOSCL THROM VAS, V26, P643, DOI 10.1161/01.ATV.0000200100.14612.bb
   Fallon P, 2009, J PSYCHIATR MENT HLT, V16, P685, DOI 10.1111/j.1365-2850.2009.01451.x
   FRONE MR, 1991, J SOC BEHAV PERS, V6, P227
   Garssen B, 2004, CLIN PSYCHOL REV, V24, P315, DOI 10.1016/j.cpr.2004.01.002
   Grundy SM, 1999, CIRCULATION, V100, P1134, DOI 10.1161/01.CIR.100.10.1134
   HAWKINS NG, 1957, AM REV TUBERC PULM, V75, P768
   Hobson CJ, 1998, INT J STRESS MANAGE, V5, P1, DOI 10.1023/A:1022978019315
   Jönsson D, 1999, J CARDIOVASC RISK, V6, P379
   Kendler KS, 1999, AM J PSYCHIAT, V156, P837, DOI 10.1176/ajp.156.6.837
   Kilpeläinen M, 2002, CLIN EXP ALLERGY, V32, P256, DOI 10.1046/j.1365-2222.2002.01282.x
   Kriegbaum M, 2008, ANN EPIDEMIOL, V18, P743, DOI 10.1016/j.annepidem.2008.04.010
   Kuper H, 2007, EPIDEMIOLOGY, V18, P764, DOI 10.1097/EDE.0b013e318142c534
   LEVITAN H, 1985, PSYCHOSOMATICS, V26, P939, DOI 10.1016/S0033-3182(85)72759-4
   Lietzén R, 2011, EUR RESPIR J, V37, P1360, DOI 10.1183/09031936.00164609
   Lim Debbie, 2000, J Ment Health Policy Econ, V3, P139, DOI 10.1002/mhp.93
   Loerbroks A, 2009, ALLERGY, V64, P1444, DOI 10.1111/j.1398-9995.2009.02019.x
   Lund R, 2012, J EPIDEMIOL COMMUN H, V66, P359, DOI 10.1136/jech.2009.106153
   Melchior M, 2007, PSYCHOL MED, V37, P1119, DOI 10.1017/S0033291707000414
   Möller J, 2005, J EPIDEMIOL COMMUN H, V59, P23, DOI 10.1136/jech.2003.019349
   Mooy JM, 2000, DIABETES CARE, V23, P197, DOI 10.2337/diacare.23.2.197
   National Public Health Partnership, 2006, BLUEPR NAT WID SURV
   Pyykkönen AJ, 2010, DIABETES CARE, V33, P378, DOI 10.2337/dc09-1027
   Räikkönen K, 2007, DIABETES CARE, V30, P872, DOI 10.2337/dc06-1857
   Schernhammer ES, 2004, AM J EPIDEMIOL, V160, P1079, DOI 10.1093/aje/kwh327
   Smith JP, 1999, J ECON PERSPECT, V13, P145, DOI 10.1257/jep.13.2.145
   Strickland OL, 2007, J CARDIOVASC NURS, V22, P272, DOI 10.1097/01.JCN.0000278964.05748.d8
   Summerfield M., 2011, HILDA USER MANUAL RE
   Train Kenneth E., 2002, Discrete Choice Methods With Simulation, V8
   Wright RJ, 1998, THORAX, V53, P1066, DOI 10.1136/thx.53.12.1066
NR 40
TC 64
Z9 68
U1 0
U2 30
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1101-1262
EI 1464-360X
J9 EUR J PUBLIC HEALTH
JI Eur. J. Public Health
PD FEB
PY 2014
VL 24
IS 1
BP 57
EP 62
DI 10.1093/eurpub/ckt007
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA AA1EC
UT WOS:000330838200014
PM 23397581
OA Bronze
DA 2025-06-11
ER

PT J
AU Tziallas, D
   Kastanioti, C
   Kostapanos, MS
   Skapinakis, P
   Elisaf, MS
   Mavreas, V
AF Tziallas, Dimitrios
   Kastanioti, Catherine
   Kostapanos, Michael S.
   Skapinakis, Petros
   Elisaf, Moses S.
   Mavreas, Venetsanos
TI The impact of the metabolic syndrome on health-related quality of life:
   a cross-sectional study in Greece
SO EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
LA English
DT Article
DE Health-related quality of life; metabolic syndrome; cardiovascular
   disease; depression
ID DEPRESSIVE SYMPTOMS; HOSPITAL ANXIETY; RISK; OBESITY; PREVALENCE;
   WEIGHT; POPULATION; COMPONENTS; SF-36
AB Background: Metabolic syndrome [MetS] is a chronic, progressive and multi-complex health problem that can trigger physical, emotional and psychosocial problems. The aim of this study is to investigate the association between MetS and health-related quality of life (HRQoL) as well as depressive and anxiety disorders.
   Methods: New consecutive patients who attended an outpatient lipid clinic for evaluation for MetS were eligible for inclusion in the study. The MetS was defined according to the new definition of International Diabetes Federation (IDF). The Medical Outcomes Study, Short Form-36 (SF-36) was used to assess HRQoL. Anxiety and depressive symptoms were assessed by a validated Greek version of the Hospital Anxiety and Depression Scale (HADS).
   Results: Three hundred and fifty-nine subjects were involved of whom 206 [57.4%] met the diagnostic criteria for the MetS (cases) and 153 [42.6%] were free of MetS criteria (comparator group). MetS was associated with lower scores of all subscales of the SF-36 except of bodily pain. The physical component summary score of SF-36 was independently associated with gender (beta = 2.41, P = .01), married or living together (beta = 5.18, P = .001) and satisfactory household income (beta = 5.77, P < .0001). The mental component summary score of SF-36 was independently associated with gender (beta = 3.20, P = .003) and satisfactory household income (beta = 3.94, P = .02). A predominance of anxiety and depressive symptoms was observed among subjects with MetS.
   Conclusions: Our study demonstrated that subjects with MetS have significantly more impaired HRQoL than those without MetS. These findings suggest that HRQoL should be considered in the management of subjects with MetS.
C1 [Tziallas, Dimitrios; Kostapanos, Michael S.; Elisaf, Moses S.] Univ Ioannina, Dept Internal Med, GR-45110 Ioannina, Greece.
   [Kastanioti, Catherine] Technol Inst Kalamata, Dept Hlth Care Management, Kalamata, Greece.
   [Skapinakis, Petros; Mavreas, Venetsanos] Univ Ioannina, Sch Med, Dept Psychiat, GR-45110 Ioannina, Greece.
C3 University of Ioannina; Technical Educational Institute Kalamata;
   University of Ioannina
RP Tziallas, D (corresponding author), Univ Hosp Ioannina, Dept Internal Med, Ioannina 45500, Greece.
EM dtziallas@gmail.com
RI Kostapanos, Michalis/AAB-2411-2020; Kastanioti, Catherine/AAM-9130-2021;
   Skapinakis, Petros/B-8718-2011
OI Skapinakis, Petros/0000-0003-1450-8051; ELISAF,
   MOSES/0000-0003-0505-078X; Kostapanos, Michalis/0000-0002-7513-5319
CR Alegría E, 2005, REV ESP CARDIOL, V58, P797, DOI 10.1157/13077231
   Athyros VG, 2005, CURR MED RES OPIN, V21, P1157, DOI 10.1185/030079905X53333
   Athyros VG, 2005, DIABETES OBES METAB, V7, P397, DOI 10.1111/j.1463-1326.2004.00409.x
   Banegas JR, 2007, EUR J CARDIOV PREV R, V14, P456, DOI 10.1097/HJR.0b013e3280803f29
   Blier P., 2006, REV PSYCHIATR NEUROS, V31, P288
   Buckland G, 2008, PUBLIC HEALTH NUTR, V11, P1372, DOI 10.1017/S1368980008003492
   Capuron L, 2008, BIOL PSYCHIAT, V64, P896, DOI 10.1016/j.biopsych.2008.05.019
   Chang PP, 2002, ARCH INTERN MED, V162, P901, DOI 10.1001/archinte.162.8.901
   Corica F, 2008, INT J OBESITY, V32, P185, DOI 10.1038/sj.ijo.0803687
   Fontaine K R, 2001, Obes Rev, V2, P173, DOI 10.1046/j.1467-789x.2001.00032.x
   Frasure-Smith N, 2005, PSYCHOSOM MED, V67, pS19, DOI 10.1097/01.psy.0000162253.07959.db
   Frisman GH, 2009, EUR J CARDIOVASC NUR, V8, P207, DOI 10.1016/j.ejcnurse.2009.01.004
   Galanis C, 2007, ARCH HELL MED, V24, P51
   Goldbacher EM, 2007, ANN BEHAV MED, V34, P240, DOI 10.1007/BF02874549
   Grundy SM, 2004, ARTERIOSCL THROM VAS, V24, pE13, DOI 10.1161/01.ATV.0000111245.75752.C6
   Han JH, 2009, INT J CLIN PRACT, V63, P735, DOI 10.1111/j.1742-1241.2009.02021.x
   Hassan MK, 2003, INT J OBESITY, V27, P1227, DOI 10.1038/sj.ijo.0802396
   Horton ES, 2009, OBESITY, V17, pS43, DOI 10.1038/oby.2009.388
   Huang IC, 2006, INT J OBESITY, V30, P1250, DOI 10.1038/sj.ijo.0803250
   Kolotkin R L, 2001, Obes Rev, V2, P219, DOI 10.1046/j.1467-789X.2001.00040.x
   Laudisio A, 2009, J GERIATR PSYCH NEUR, V22, P215, DOI 10.1177/0891988709335793
   Maciejewski ML, 2005, J CLIN EPIDEMIOL, V58, P568, DOI 10.1016/j.jclinepi.2004.10.015
   Malik Shaista, 2009, Expert Rev Cardiovasc Ther, V7, P273, DOI 10.1586/14779072.7.3.273
   McIntyre RS, 2009, CURR DIABETES REP, V9, P51, DOI 10.1007/s11892-009-0010-0
   Miettola J, 2008, SCAND J PRIM HEALTH, V26, P203, DOI 10.1080/02813430802117624
   Milionis HJ, 2005, STROKE, V36, P1372, DOI 10.1161/01.STR.0000169935.35394.38
   Mystakidou K, 2004, SUPPORT CARE CANCER, V12, P821, DOI 10.1007/s00520-004-0698-y
   NAVARRO V, 1990, LANCET, V336, P1238, DOI 10.1016/0140-6736(90)92846-A
   Neumann NU, 2009, PSYCHIAT PRAX, V36, P110, DOI 10.1055/s-2008-1067558
   Panagiotakos DB, 2007, J AM DIET ASSOC, V107, P979, DOI 10.1016/j.jada.2007.03.006
   Pappa E, 2005, QUAL LIFE RES, V14, P1433, DOI 10.1007/s11136-004-6014-y
   Poljicanin T, 2010, DIABETES MELLITUS HY, V10, P12
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Sullivan PW, 2007, OBESITY, V15, P511, DOI 10.1038/oby.2007.580
   Tsai AG, 2008, OBESITY, V16, P59, DOI 10.1038/oby.2007.8
   Vanhala M, 2009, ACTA PSYCHIAT SCAND, V119, P137, DOI 10.1111/j.1600-0447.2008.01283.x
   Wadden Thomas A, 2002, Obes Res, V10 Suppl 1, p50S, DOI 10.1038/oby.2002.190
   Ware J. E., 1994, SF-36 physical and mental summary scales: A users manual
   WARE JE, 1992, MED CARE, V30, P473, DOI 10.1097/00005650-199206000-00002
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 40
TC 38
Z9 41
U1 0
U2 9
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1474-5151
EI 1873-1953
J9 EUR J CARDIOVASC NUR
JI Eur. J. Cardiovasc. Nurs.
PD SEP
PY 2012
VL 11
IS 3
SI SI
BP 297
EP 303
DI 10.1016/j.ejcnurse.2011.02.004
PG 7
WC Cardiac & Cardiovascular Systems; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Nursing
GA 046YQ
UT WOS:000311802200007
PM 21398183
OA Bronze
DA 2025-06-11
ER

PT J
AU Pischke, CR
   Frenda, S
   Ornish, D
   Weidner, G
AF Pischke, Claudia Ruth
   Frenda, Steven
   Ornish, Dean
   Weidner, Gerdi
TI Lifestyle changes are related to reductions in depression in persons
   with elevated coronary risk factors
SO PSYCHOLOGY & HEALTH
LA English
DT Article
DE elevated coronary risk factors; depressive symptoms; lifestyle changes
ID TYPE-2 DIABETES-MELLITUS; METABOLIC SYNDROME; HEART-DISEASE;
   PHYSICAL-ACTIVITY; GLYCEMIC CONTROL; PREVENTION; SYMPTOMS; EXERCISE;
   DIET; PREVALENCE
AB This observational study investigates whether persons with elevated coronary risk factors (CRFs 3 and/or diabetes) and depression [i.e., epsilon 16 on the Center for Epidemiological Scale - Depression (CES-D)] can make changes in health behaviours over 3 months and improve depressive symptoms and other CRFs. Analyses were based on data from 310 men and 687 women enrolled in the high-risk arm of the Multisite Cardiac Lifestyle Intervention Program, targeting diet (10% fat), exercise (3 h per week) and stress management (7 h per week). As expected, at study entry, depressed persons had a more adverse medical status, consumed more dietary fat and practiced less stress management than non-depressed persons. To examine 3-month changes, participants were grouped into (1) depressed persons who became non-depressed (CES-D 16, n = 248; 73%), (2) persons who remained or became depressed (CES-D 16, n = 76) and (3) non-depressed persons who remained non-depressed (n = 597). All persons, regardless of group, met program goals. The greatest improvements (i.e., diet, exercise, perceived stress, hostility and mental health) were observed in Group 1 relative to Groups 2 and 3, which did not differ from each other. Comprehensive lifestyle changes appear to be feasible and beneficial for initially depressed persons with elevated CRFs.
C1 [Weidner, Gerdi] San Francisco State Univ, Tiburon, CA 94920 USA.
   [Weidner, Gerdi] Johannes Gutenberg Univ Mainz, D-55122 Mainz, Germany.
   [Pischke, Claudia Ruth] Harvard Univ, Sch Publ Hlth, Dana Farber Canc Inst, Boston, MA 02130 USA.
   [Frenda, Steven; Ornish, Dean] Res Inst Prevent Med, Sausalito, CA 94965 USA.
C3 California State University System; San Francisco State University;
   Johannes Gutenberg University of Mainz; Harvard University; Harvard
   University Medical Affiliates; Dana-Farber Cancer Institute; Harvard
   T.H. Chan School of Public Health
RP Weidner, G (corresponding author), San Francisco State Univ, 3150 Paradise Dr, Tiburon, CA 94920 USA.
EM gweidner@sfsu.edu
OI Pischke, Claudia/0000-0002-2256-8903
CR Am Diabetes Assoc, 2006, DIABETES CARE, V29, pS4
   Anstey KJ, 2002, PSYCHOSOM MED, V64, P880, DOI 10.1097/01.PSY.0000028827.64279.60
   BAREFOOT JC, 1989, PSYCHOSOM MED, V51, P46, DOI 10.1097/00006842-198901000-00005
   Bianchi C, 2007, EXPERT REV CARDIOVAS, V5, P491, DOI 10.1586/14779072.5.3.491
   Billings JH, 2000, HEALTH PSYCHOL, V19, P70, DOI 10.1037/0278-6133.19.Suppl1.70
   Blumenthal James A, 2008, Cleve Clin J Med, V75 Suppl 2, pS48
   Boulé NG, 2001, JAMA-J AM MED ASSOC, V286, P1218, DOI 10.1001/jama.286.10.1218
   Boulé NG, 2003, DIABETOLOGIA, V46, P1071, DOI 10.1007/s00125-003-1160-2
   Brenes Gretchen A, 2007, Prim Care Companion J Clin Psychiatry, V9, P437
   BRINTON EA, 1990, J CLIN INVEST, V85, P144, DOI 10.1172/JCI114405
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Costacou T, 2003, ANNU REV NUTR, V23, P147, DOI 10.1146/annurev.nutr.23.011702.073027
   Davidson KW, 2005, PSYCHOSOM MED, V67, pS6, DOI 10.1097/01.psy.0000162257.19266.fc
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Elmer PJ, 2006, ANN INTERN MED, V144, P485, DOI 10.7326/0003-4819-144-7-200604040-00007
   Espeland M, 2007, DIABETES CARE, V30, P1374
   FARMER ME, 1988, AM J EPIDEMIOL, V128, P1340, DOI 10.1093/oxfordjournals.aje.a115087
   Ford ES, 2005, DIABETES CARE, V28, P2745, DOI 10.2337/diacare.28.11.2745
   Frattaroli J, 2008, AM J CARDIOL, V101, P911, DOI 10.1016/j.amjcard.2007.11.039
   Georgiades A, 2007, PSYCHOSOM MED, V69, P235, DOI 10.1097/PSY.0b013e318042588d
   Gerstein HC, 2008, NEW ENGL J MED, V358, P2545, DOI 10.1056/NEJMoa0802743
   Gonzalez JS, 2007, DIABETES CARE, V30, P2222, DOI 10.2337/dc07-0158
   Goodman E, 2002, PEDIATRICS, V110, P497, DOI 10.1542/peds.110.3.497
   GOVIL SR, 2008, AM J PUBLIC HLTH
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Hainer V, 2008, PHYSIOL RES, V57, pI
   Hu FB, 2002, JAMA-J AM MED ASSOC, V288, P2569, DOI 10.1001/jama.288.20.2569
   Katon WJ, 2004, J GEN INTERN MED, V19, P1192, DOI 10.1111/j.1525-1497.2004.30405.x
   Knowler WC, 2002, NEW ENGL J MED, V346, P393, DOI 10.1056/nejmoa012512
   Kronenberg F, 2000, ATHEROSCLEROSIS, V153, P433, DOI 10.1016/S0021-9150(00)00426-3
   Lespérance F, 2000, ARCH INTERN MED, V160, P1354, DOI 10.1001/archinte.160.9.1354
   Lett HS, 2005, PSYCHOSOM MED, V67, pS58, DOI 10.1097/01.psy.0000163453.24417.97
   Lichtman JH, 2008, CIRCULATION, V118, P1768, DOI 10.1161/CIRCULATIONAHA.108.190769
   Lindström J, 2006, LANCET, V368, P1673, DOI 10.1016/S0140-6736(06)69701-8
   Mendell N, 2007, ANN BEHAV MED, V33, P57, DOI 10.1207/s15324796abm3301_7
   Orchard TJ, 2005, ANN INTERN MED, V142, P611, DOI 10.7326/0003-4819-142-8-200504190-00009
   Ornish D, 1998, JAMA-J AM MED ASSOC, V280, P2001, DOI 10.1001/jama.280.23.2001
   ORNISH D, 1983, JAMA-J AM MED ASSOC, V249, P54, DOI 10.1001/jama.249.1.54
   ORNISH D, 1990, LANCET, V336, P129, DOI 10.1016/0140-6736(90)91656-U
   Pampallona S, 2002, BRIT J PSYCHIAT, V180, P104, DOI 10.1192/bjp.180.2.104
   Pan XR, 1997, DIABETES CARE, V20, P537, DOI 10.2337/diacare.20.4.537
   Patton GC, 1998, AM J PUBLIC HEALTH, V88, P1518, DOI 10.2105/AJPH.88.10.1518
   Penninx BWJH, 1999, ARCH GEN PSYCHIAT, V56, P889, DOI 10.1001/archpsyc.56.10.889
   Pischke CR, 2008, HEALTH PSYCHOL, V27, P584, DOI 10.1037/0278-6133.27.5.584
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Räikkönen K, 2007, DIABETES CARE, V30, P872, DOI 10.2337/dc06-1857
   RAJALA U, 1994, SOC PSYCH PSYCH EPID, V29, P126
   Rowan PJ, 2005, ANN EPIDEMIOL, V15, P316, DOI 10.1016/j.annepidem.2004.08.006
   Rugulies R, 2002, AM J PREV MED, V23, P51, DOI 10.1016/S0749-3797(02)00439-7
   Saydah SH, 2003, DIABETES-METAB RES, V19, P202, DOI 10.1002/dmrr.353
   Schulz Ute, 2008, Psychol Health Med, V13, P423, DOI 10.1080/13548500701660442
   SHINAR D, 1986, STROKE, V17, P241, DOI 10.1161/01.STR.17.2.241
   Stampfer MJ, 2000, NEW ENGL J MED, V343, P16, DOI 10.1056/NEJM200007063430103
   Steptoe A, 1997, PREV MED, V26, P845, DOI 10.1006/pmed.1997.0224
   Toobert DJ, 2007, INT J BEHAV NUTR PHY, V4, DOI 10.1186/1479-5868-4-1
   Toobert DJ, 2005, ANN BEHAV MED, V29, P128, DOI 10.1207/s15324796abm2902_7
   Tuomilehto J, 2001, NEW ENGL J MED, V344, P1343, DOI 10.1056/NEJM200105033441801
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
   Vickers KS, 2006, AM J HEALTH BEHAV, V30, P353, DOI 10.5993/AJHB.30.4.2
   Ware J.E., 2003, SF 36 HLTH SURVEY MA
   Ware J. E., 1994, SF-36 physical and mental summary scales: A users manual
   WEISSMAN MM, 1977, AM J EPIDEMIOL, V106, P203, DOI 10.1093/oxfordjournals.aje.a112455
   Whaley MH., 2006, ACSM's Guidelines for Exercise Testing and Prescription
   WISTER A, 2007, CANADIAN MED ASS J, V177, P887
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
   Zhang XP, 2005, AM J EPIDEMIOL, V161, P652, DOI 10.1093/aje/kwi089
NR 67
TC 15
Z9 19
U1 0
U2 20
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0887-0446
EI 1476-8321
J9 PSYCHOL HEALTH
JI Psychol. Health
PY 2010
VL 25
IS 9
BP 1077
EP 1100
AR PII 917229765
DI 10.1080/08870440903002986
PG 24
WC Public, Environmental & Occupational Health; Psychology,
   Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Psychology
GA 676BI
UT WOS:000283884700004
PM 20204946
DA 2025-06-11
ER

PT J
AU Heiskanen, TH
   Niskanen, LK
   Hintikka, JJ
   Koivumaa-Honkanen, HT
   Honkalampi, KM
   Haatainen, KM
   Viinamäki, HT
AF Heiskanen, Tuula H.
   Niskanen, Leo K.
   Hintikka, Jukka J.
   Koivumaa-Honkanen, Heli T.
   Honkalampi, Kirsi M.
   Haatainen, Kaisa M.
   Viinamaki, Heimo T.
TI Metabolic syndrome and depression:: A cross-sectional analysis
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID TORONTO-ALEXITHYMIA-SCALE; INSULIN-RESISTANCE; PSYCHOMETRIC PROPERTIES;
   RISK; MORTALITY; PREVALENCE; SYMPTOMS; DISEASE; HEART; SCHIZOPHRENIA
AB Objective: To examine the prevalence of the metabolic syndrome in depressive outpatients and to identify its correlates in depression.
   Method: This cross-sectional analysis was performed on 121 depressive outpatients from January 2002 through January 2004 who were diagnosed at baseline with the Structured Clinical Interview for DSM-III-R. The metabolic syndrome was diagnosed at 6-year follow-up according to the modified criteria of the National Cholesterol Education Program. The severity of depressive symptoms was assessed at follow-up with the Beck Depression Inventory and the Hamilton Rating Scale for Depression, and general psychopathology was assessed with the Symptom Checklist-90.
   Results: At 6-year follow-up, the prevalence of metabolic syndrome in the study group of depressive outpatients was 36% (N = 44). The syndrome was associated with a current diagnosis of major depression and overeating, but not with age or sex.
   Conclusion: The metabolic syndrome is highly prevalent among patients with a history of depression, especially those with current major depression. This may have implications for treatment. Furthermore, attention should be focused on the physical health of those suffering from depression.
C1 Kuopio Univ Hosp, Dept Psychiat, FIN-70211 Kuopio, Finland.
   Kuopio Univ Hosp, Dept Med, FIN-70211 Kuopio, Finland.
   Paijat Hame Cent Hosp, Dept Psychiat, Lahti, Finland.
   Univ Tampere, Dept Psychiat, FIN-33101 Tampere, Finland.
C3 Kuopio University Hospital; Kuopio University Hospital; Paijat Hame
   Central Hospital; Tampere University
RP Heiskanen, TH (corresponding author), Kuopio Univ Hosp, Dept Psychiat, POB 1777, FIN-70211 Kuopio, Finland.
EM tuula.heiskanen@kuh.fi
RI Koivumaa-Honkanen, Heli/L-1274-2015
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   BAGBY RM, 1994, J PSYCHOSOM RES, V38, P33, DOI 10.1016/0022-3999(94)90006-X
   BAGBY RM, 1994, J PSYCHOSOM RES, V38, P23, DOI 10.1016/0022-3999(94)90005-1
   BECK AT, 1988, CLIN PSYCHOL REV, V8, P77, DOI 10.1016/0272-7358(88)90050-5
   BECK AT, 1974, J CONSULT CLIN PSYCH, V42, P861, DOI 10.1037/h0037562
   BOUCHARD C, 1995, INT J OBESITY, V19, pS52
   Brown ES, 2004, BIOL PSYCHIAT, V55, P1, DOI 10.1016/S0006-3223(03)00473-6
   Brown LC, 2005, DIABETES CARE, V28, P1063, DOI 10.2337/diacare.28.5.1063
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cohn T, 2004, CAN J PSYCHIAT, V49, P753, DOI 10.1177/070674370404901106
   DEROGATIS L R, 1973, Psychopharmacology Bulletin, V9, P13
   Di Marzo V, 2005, NAT NEUROSCI, V8, P585, DOI 10.1038/nn1457
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Evans DL, 2005, BIOL PSYCHIAT, V58, P175, DOI 10.1016/j.biopsych.2005.05.001
   Everson-Rose SA, 2004, DIABETES CARE, V27, P2856, DOI 10.2337/diacare.27.12.2856
   Facchini FS, 2001, J CLIN ENDOCR METAB, V86, P3574, DOI 10.1210/jc.86.8.3574
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   Ford ES, 2005, DIABETES CARE, V28, P2745, DOI 10.2337/diacare.28.11.2745
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Heiskanen T, 2003, J CLIN PSYCHIAT, V64, P575, DOI 10.4088/JCP.v64n0513
   Holi MM, 2003, NORD J PSYCHIAT, V57, P233, DOI 10.1080/08039480310001418
   Hu G, 2004, ARCH INTERN MED, V164, P1066, DOI 10.1001/archinte.164.10.1066
   Hulthe J, 2000, ARTERIOSCL THROM VAS, V20, P2140, DOI 10.1161/01.ATV.20.9.2140
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Joukamaa M, 2001, NORD J PSYCHIAT, V55, P123, DOI 10.1080/08039480151108561
   Judd LL, 1998, ARCH GEN PSYCHIAT, V55, P694, DOI 10.1001/archpsyc.55.8.694
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Koivumaa-Honkanen H, 2001, AM J PSYCHIAT, V158, P433, DOI 10.1176/appi.ajp.158.3.433
   Korhonen S, 2001, AM J OBSTET GYNECOL, V184, P289, DOI 10.1067/mob.2001.109596
   Laaksonen DE, 2004, ANN MED, V36, P332, DOI 10.1080/07853890410031849
   Laaksonen DE, 2002, AM J EPIDEMIOL, V156, P1070, DOI 10.1093/aje/kwf145
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lasa L, 2000, J AFFECT DISORDERS, V57, P261, DOI 10.1016/S0165-0327(99)00088-9
   Lawlor DA, 2003, BRIT MED J, V327, P1383, DOI 10.1136/bmj.327.7428.1383
   Liese AD, 1998, EPIDEMIOL REV, V20, P157, DOI 10.1093/oxfordjournals.epirev.a017978
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Saari KM, 2005, J CLIN PSYCHIAT, V66, P559, DOI 10.4088/JCP.v66n0503
   Spitzer R.L., 1996, Outcome assessment in clinical practice, P76
   SPITZER RL, 1992, ARCH GEN PSYCHIAT, V49, P624
   Timonen M, 2005, BMJ-BRIT MED J, V330, P17, DOI 10.1136/bmj.38313.513310.F71
   Tuomilehto J, 2005, DIABETES RES CLIN PR, V68, pS28, DOI 10.1016/j.diabres.2005.03.018
   Vanhala M J, 1997, J Cardiovasc Risk, V4, P291, DOI 10.1097/00043798-199708000-00010
   WELLS KB, 1989, JAMA-J AM MED ASSOC, V262, P914, DOI 10.1001/jama.262.7.914
   Wulsin LR, 1999, PSYCHOSOM MED, V61, P6, DOI 10.1097/00006842-199901000-00003
   Wulsin LR, 2003, PSYCHOSOM MED, V65, P201, DOI 10.1097/01.PSY.0000058371.50240.E3
NR 47
TC 121
Z9 129
U1 1
U2 11
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD SEP
PY 2006
VL 67
IS 9
BP 1422
EP 1427
DI 10.4088/JCP.v67n0913
PG 6
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 095WN
UT WOS:000241339100013
PM 17017829
DA 2025-06-11
ER

PT J
AU Roberts, CK
   Hevener, AL
   Barnard, RJ
AF Roberts, Christian K.
   Hevener, Andrea L.
   Barnard, R. James
TI Metabolic Syndrome and Insulin Resistance: Underlying Causes and
   Modification by Exercise Training
SO COMPREHENSIVE PHYSIOLOGY
LA English
DT Article
ID C-REACTIVE PROTEIN; HUMAN SKELETAL-MUSCLE; NECROSIS-FACTOR-ALPHA; TIME
   PHYSICAL-ACTIVITY; ENDOPLASMIC-RETICULUM STRESS; SUBCUTANEOUS
   ADIPOSE-TISSUE; TYPE-2 DIABETES-MELLITUS; TYROSINE-PHOSPHATASE 1B;
   ACID-BINDING PROTEIN; ACYLATION-STIMULATING PROTEIN
AB Metabolic syndrome (MS) is a collection of cardiometabolic risk factors that includes obesity, insulin resistance, hypertension, and dyslipidemia. Although there has been significant debate regarding the criteria and concept of the syndrome, this clustering of risk factors is unequivocally linked to an increased risk of developing type 2 diabetes and cardiovascular disease. Regardless of the true definition, based on current population estimates, nearly 100 million have MS. It is often characterized by insulin resistance, which some have suggested is a major underpinning link between physical inactivity and MS. The purpose of this review is to: (i) provide an overview of the history, causes and clinical aspects of MS, (ii) review the molecular mechanisms of insulin action and the causes of insulin resistance, and (iii) discuss the epidemiological and intervention data on the effects of exercise on MS and insulin sensitivity. (C) 2013 American Physiological Society. Compr Physiol 3:1-58, 2013.
C1 [Roberts, Christian K.] Univ Calif Los Angeles, Sch Nursing, Translat Sci Sect, Exercise & Metab Dis Res Lab, Los Angeles, CA 90024 USA.
   [Hevener, Andrea L.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Endocrinol, Los Angeles, CA 90095 USA.
   [Barnard, R. James] Univ Calif Los Angeles, Dept Integrat Biol & Physiol, Los Angeles, CA USA.
C3 University of California System; University of California Los Angeles;
   University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA; University of California System; University of
   California Los Angeles
RP Roberts, CK (corresponding author), Univ Calif Los Angeles, Sch Nursing, Translat Sci Sect, Exercise & Metab Dis Res Lab, Los Angeles, CA 90024 USA.
EM croberts@ucla.edu
RI Stefanadis, Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454
CR Abdul-Ghani MA, 2007, DIABETES CARE, V30, P1544, DOI 10.2337/dc06-1331
   Abdul-Ghani MA, 2007, DIABETES CARE, V30, P89, DOI 10.2337/dc06-1519
   Abel ED, 2001, NATURE, V409, P729, DOI 10.1038/35055575
   ABUMRAD NA, 1993, J BIOL CHEM, V268, P17665
   ABUMRAD NA, 1981, J BIOL CHEM, V256, P9183
   Adams JM, 2004, DIABETES, V53, P25, DOI 10.2337/diabetes.53.1.25
   ADER M, 1987, BAILLIERE CLIN ENDOC, V1, P879, DOI 10.1016/S0950-351X(87)80010-1
   Aguirre V, 2002, J BIOL CHEM, V277, P1531, DOI 10.1074/jbc.M101521200
   Aguirre V, 2000, J BIOL CHEM, V275, P9047, DOI 10.1074/jbc.275.12.9047
   Ahima RS, 1999, ENDOCRINOLOGY, V140, P4923, DOI 10.1210/en.140.11.4923
   Ahmad F, 1997, METABOLISM, V46, P1140, DOI 10.1016/S0026-0495(97)90206-7
   Ahmad F, 1997, J CLIN INVEST, V100, P449, DOI 10.1172/JCI119552
   Ahmadi N, 2011, AM J MED, V124, P978, DOI 10.1016/j.amjmed.2011.02.032
   Al-Khalili L, 2006, MOL ENDOCRINOL, V20, P3364, DOI 10.1210/me.2005-0490
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Amati F, 2011, DIABETES, V60, P2588, DOI 10.2337/db10-1221
   Andersen JL, 2003, J PHYSIOL-LONDON, V551, P1049, DOI 10.1113/jphysiol.2003.043554
   Andersen JN, 2001, MOL CELL BIOL, V21, P7117, DOI 10.1128/MCB.21.21.7117-7136.2001
   Anderssen SA, 2007, SCAND J MED SCI SPOR, V17, P687, DOI 10.1111/j.1600-0838.2006.00631.x
   Andersson N, 2010, INT J OBESITY, V34, P1011, DOI 10.1038/ijo.2010.27
   [Anonymous], INT J OBES LOND
   [Anonymous], DIABETES RES
   [Anonymous], PREVALENCE METABOLIC
   [Anonymous], 2008, Physical Activity Guidelines Advisory Committee: Physical activity guidelines advisory committee report, 2008
   [Anonymous], EUR J APPL PHYSL
   [Anonymous], 2005, WORLDW DEF MET SYNDR
   [Anonymous], COMPREHENSIVE PHYSL
   Aquilante CL, 2008, METABOLISM, V57, P494, DOI 10.1016/j.metabol.2007.11.010
   ARAKI E, 1994, NATURE, V372, P186, DOI 10.1038/372186a0
   Araújo EP, 2005, ENDOCRINOLOGY, V146, P1428, DOI 10.1210/en.2004-0778
   Arita Y, 1999, BIOCHEM BIOPH RES CO, V257, P79, DOI 10.1006/bbrc.1999.0255
   Arkan MC, 2005, NAT MED, V11, P191, DOI 10.1038/nm1185
   Arner P, 2008, FEBS LETT, V582, P1725, DOI 10.1016/j.febslet.2008.04.038
   Aron-Wisnewsky J, 2009, J CLIN ENDOCR METAB, V94, P4619, DOI 10.1210/jc.2009-0925
   Aronson D, 2004, ATHEROSCLEROSIS, V176, P173, DOI 10.1016/j.atherosclerosis.2004.04.025
   Aronson D, 2004, J AM COLL CARDIOL, V44, P2003, DOI 10.1016/j.jacc.2004.08.030
   Atlantis E, 2009, METABOLISM, V58, P1013, DOI 10.1016/j.metabol.2009.02.027
   Avorn J, 1998, JAMA-J AM MED ASSOC, V279, P1458, DOI 10.1001/jama.279.18.1458
   Ay L, 2010, J THROMB HAEMOST, V8, P759, DOI 10.1111/j.1538-7836.2010.03766.x
   Babraj JA, 2009, BMC ENDOCR DISORD, V9, DOI 10.1186/1472-6823-9-3
   Bacchi E, 2012, DIABETES CARE, V35, P676, DOI 10.2337/dc11-1655
   Bae SS, 2003, J BIOL CHEM, V278, P49530, DOI 10.1074/jbc.M306782200
   BALDO A, 1995, J LIPID RES, V36, P1415
   Balducci S, 2010, ARCH INTERN MED, V170, P1794, DOI 10.1001/archinternmed.2010.380
   Balkau B, 1999, DIABETIC MED, V16, P442
   Balkau B, 2008, DIABETES, V57, P2613, DOI 10.2337/db07-1605
   Bandyopadhyay GK, 2005, DIABETES, V54, P2351, DOI 10.2337/diabetes.54.8.2351
   Banerjee RR, 2004, SCIENCE, V303, P1195, DOI 10.1126/science.1092341
   Banks E A, 1992, Am J Physiol, V263, pE1010
   BARAKAT HA, 1990, DIABETES, V39, P1527, DOI 10.2337/diabetes.39.12.1527
   Barbieri M, 2010, J GERONTOL A-BIOL, V65, P282, DOI 10.1093/gerona/glp154
   Barnard RJ, 2007, AM J CLIN NUTR, V86, p889S, DOI 10.1093/ajcn/86.3.889S
   Barnard RJ, 1998, J APPL PHYSIOL, V84, P1311, DOI 10.1152/jappl.1998.84.4.1311
   BARNARD RJ, 1995, GERONTOLOGY, V41, P205
   BARNARD RJ, 1993, ATHEROSCLEROSIS, V100, P229, DOI 10.1016/0021-9150(93)90209-D
   BARNARD RJ, 1994, SPORTS MED, V18, P218, DOI 10.2165/00007256-199418040-00002
   BARON AD, 1994, AM J PHYSIOL, V267, pE187, DOI 10.1152/ajpendo.1994.267.2.E187
   Barwell ND, 2008, DIABETOLOGIA, V51, P1912, DOI 10.1007/s00125-008-1097-6
   Bastard JP, 2000, J CLIN ENDOCR METAB, V85, P3338, DOI 10.1210/jc.85.9.3338
   Baumann CA, 2000, NATURE, V407, P202, DOI 10.1038/35025089
   Befroy DE, 2007, DIABETES, V56, P1376, DOI 10.2337/db06-0783
   Benetos A, 2008, AM J CARDIOL, V102, P188, DOI 10.1016/j.amjcard.2008.03.037
   Benner JS, 2002, JAMA-J AM MED ASSOC, V288, P455, DOI 10.1001/jama.288.4.455
   Benrick A, 2008, REGUL PEPTIDES, V146, P189, DOI 10.1016/j.regpep.2007.09.031
   Bento JL, 2004, DIABETES, V53, P3007, DOI 10.2337/diabetes.53.11.3007
   Berg AH, 2001, NAT MED, V7, P947, DOI 10.1038/90992
   Berglund ED, 2009, ENDOCRINOLOGY, V150, P4084, DOI 10.1210/en.2009-0221
   BERGMAN RN, 1989, DIABETES, V38, P1512, DOI 10.2337/diabetes.38.12.1512
   Bezaire V, 2006, AM J PHYSIOL-ENDOC M, V290, pE509, DOI 10.1152/ajpendo.00312.2005
   Bjorbaek C, 1998, MOL CELL, V1, P619, DOI 10.1016/S1097-2765(00)80062-3
   Bjorbæk C, 2000, J BIOL CHEM, V275, P40649, DOI 10.1074/jbc.M007577200
   BJORNTORP P, 1972, METABOLISM, V21, P1037, DOI 10.1016/0026-0495(72)90034-0
   BJORNTORP P, 1990, ARTERIOSCLEROSIS, V10, P493, DOI 10.1161/01.ATV.10.4.493
   Blühre M, 2009, EXP CLIN ENDOCR DIAB, V117, P241, DOI 10.1055/s-0029-1192044
   Bo S, 2007, J GEN INTERN MED, V22, P1695, DOI 10.1007/s11606-007-0399-6
   Bonen A, 2000, J BIOL CHEM, V275, P14501, DOI 10.1074/jbc.275.19.14501
   Bonen A, 1999, AM J PHYSIOL-ENDOC M, V276, pE642, DOI 10.1152/ajpendo.1999.276.4.E642
   Booth FW, 2009, J PHYSIOL-LONDON, V587, P5527, DOI 10.1113/jphysiol.2009.179507
   Bouchard C, 1999, J APPL PHYSIOL, V87, P1003, DOI 10.1152/jappl.1999.87.3.1003
   Boulé NG, 2005, DIABETES CARE, V28, P108, DOI 10.2337/diacare.28.1.108
   Bozaoglu K, 2007, ENDOCRINOLOGY, V148, P4687, DOI 10.1210/en.2007-0175
   Bozaoglu K, 2009, J CLIN ENDOCR METAB, V94, P3085, DOI 10.1210/jc.2008-1833
   BRAUN B, 1995, J APPL PHYSIOL, V78, P300, DOI 10.1152/jappl.1995.78.1.300
   Brouwer BG, 2007, AM HEART J, V154, P1146, DOI 10.1016/j.ahj.2007.07.031
   BROZINICK JT, 1994, AM J PHYSIOL, V267, pR236, DOI 10.1152/ajpregu.1994.267.1.R236
   Brozinick JT, 2001, DIABETES, V50, P593, DOI 10.2337/diabetes.50.3.593
   Bruce CR, 2006, AM J PHYSIOL-ENDOC M, V291, pE99, DOI 10.1152/ajpendo.00587.2005
   Bruce CR, 2009, DIABETES, V58, P550, DOI 10.2337/db08-1078
   Bruce CR, 2004, MED SCI SPORT EXER, V36, P1196, DOI 10.1249/01.MSS.0000074670.03001.98
   Bruce CR, 2003, DIABETES, V52, P2338, DOI 10.2337/diabetes.52.9.2338
   Bryant NJ, 2002, NAT REV MOL CELL BIO, V3, P267, DOI 10.1038/nrm782
   Burgomaster KA, 2005, J APPL PHYSIOL, V98, P1985, DOI 10.1152/japplphysiol.01095.2004
   Burguera B, 2000, AM J PHYSIOL-ENDOC M, V278, pE113, DOI 10.1152/ajpendo.2000.278.1.E113
   BURSTEIN R, 1985, DIABETES, V34, P756, DOI 10.2337/diabetes.34.8.756
   Busch AK, 2005, DIABETES, V54, P2917, DOI 10.2337/diabetes.54.10.2917
   Cai DS, 2005, NAT MED, V11, P183, DOI 10.1038/nm1166
   Camhi SM, 2010, OBESITY, V18, P548, DOI 10.1038/oby.2009.304
   Campbell SE, 2004, J BIOL CHEM, V279, P36235, DOI 10.1074/jbc.M400566200
   Camus J P, 1966, Rev Rhum Mal Osteoartic, V33, P10
   Caranti DA, 2007, METABOLISM, V56, P1293, DOI 10.1016/j.metabol.2007.05.004
   Carey AL, 2009, DIABETOLOGIA, V52, P2015, DOI 10.1007/s00125-009-1420-x
   Carey AL, 2006, DIABETOLOGIA, V49, P1000, DOI 10.1007/s00125-006-0178-7
   Carey AL, 2006, DIABETES, V55, P2688, DOI 10.2337/db05-1404
   Carnethon MR, 2003, JAMA-J AM MED ASSOC, V290, P3092, DOI 10.1001/jama.290.23.3092
   Carroll S, 2000, MED SCI SPORT EXER, V32, P2079, DOI 10.1097/00005768-200012000-00018
   CARSWELL EA, 1975, P NATL ACAD SCI USA, V72, P3666, DOI 10.1073/pnas.72.9.3666
   Castaneda Francisco, 2006, Int J Med Sci, V3, P84
   Catalan V, 2009, J MOL MED, V87, P803, DOI 10.1007/s00109-009-0486-8
   Cauza E, 2005, EUR J CLIN INVEST, V35, P745, DOI 10.1111/j.1365-2362.2005.01573.x
   Cha BS, 2005, AM J PHYSIOL-ENDOC M, V289, pE151, DOI 10.1152/ajpendo.00141.2004
   Chadt A, 2008, NAT GENET, V40, P1354, DOI 10.1038/ng.244
   Chaika OV, 1999, J BIOL CHEM, V274, P12075, DOI 10.1074/jbc.274.17.12075
   Chang L, 2004, MOL MED, V10, P65, DOI 10.2119/2005-00029.Saltiel
   Chavey C, 2009, CELL METAB, V9, P339, DOI 10.1016/j.cmet.2009.03.002
   Chen AK, 2006, METABOLISM, V55, P871, DOI 10.1016/j.metabol.2006.03.001
   Chen H, 1996, CELL, V84, P491, DOI 10.1016/S0092-8674(00)81294-5
   Chiang SH, 2001, NATURE, V410, P944, DOI 10.1038/35073608
   Cho ER, 2009, ANN EPIDEMIOL, V19, P784, DOI 10.1016/j.annepidem.2009.06.010
   Cho YM, 2004, DIABETOLOGIA, V47, P559, DOI 10.1007/s00125-003-1319-x
   Choi CS, 2007, P NATL ACAD SCI USA, V104, P16480, DOI 10.1073/pnas.0706794104
   Christ-Roberts CY, 2004, METABOLISM, V53, P1233, DOI 10.1016/j.metabol.2004.03.022
   Chung J, 2008, P NATL ACAD SCI USA, V105, P1739, DOI 10.1073/pnas.0705799105
   Chung SS, 2005, DIABETOLOGIA, V48, P1150, DOI 10.1007/s00125-005-1762-y
   Church TS, 2009, BRIT J SPORT MED, V43, P80, DOI 10.1136/bjsm.2008.053850
   Churilla JR, 2009, DIABETES VASC DIS RE, V6, P100, DOI 10.1177/1479164109336040
   Cianflone K, 2003, BBA-BIOMEMBRANES, V1609, P127, DOI 10.1016/S0005-2736(02)00686-7
   Cipolletta D, 2011, SEMIN IMMUNOL, V23, P431, DOI 10.1016/j.smim.2011.06.002
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Clevenger CM, 2002, J APPL PHYSIOL, V93, P2105, DOI 10.1152/japplphysiol.00315.2002
   Coe NR, 1998, BBA-LIPID LIPID MET, V1391, P287, DOI 10.1016/S0005-2760(97)00205-1
   Coker RH, 2006, MED SCI SPORT EXER, V38, P433, DOI 10.1249/01.mss.0000191417.48710.11
   Comuzzie AG, 2001, J CLIN ENDOCR METAB, V86, P4321, DOI 10.1210/jc.86.9.4321
   Copps KD, 2010, CELL METAB, V11, P84, DOI 10.1016/j.cmet.2009.11.003
   Cortez-Cooper MY, 2005, AM J HYPERTENS, V18, P930, DOI 10.1016/j.amjhyper.2005.01.008
   Coskun T, 2008, ENDOCRINOLOGY, V149, P6018, DOI 10.1210/en.2008-0816
   Cox JH, 1999, J APPL PHYSIOL, V86, P2019, DOI 10.1152/jappl.1999.86.6.2019
   CRAIG BW, 1989, MECH AGEING DEV, V49, P147, DOI 10.1016/0047-6374(89)90098-5
   Crimmins NA, 2007, OBES REV, V8, P419, DOI 10.1111/j.1467-789X.2007.00348.x
   Crowe S, 2009, CELL METAB, V10, P40, DOI 10.1016/j.cmet.2009.06.001
   Cuff DJ, 2003, DIABETES CARE, V26, P2977, DOI 10.2337/diacare.26.11.2977
   CZECH MP, 1985, ANNU REV PHYSIOL, V47, P357, DOI 10.1146/annurev.ph.47.030185.002041
   D'Aiuto F, 2008, J CLIN ENDOCR METAB, V93, P3989, DOI 10.1210/jc.2007-2522
   D'Alessandris C, 2007, DIABETOLOGIA, V50, P840, DOI 10.1007/s00125-006-0522-y
   da Luz G, 2011, EUR J APPL PHYSIOL, V111, P2015, DOI 10.1007/s00421-010-1802-2
   Daray LA, 2011, APPL PHYSIOL NUTR ME, V36, P660, DOI [10.1139/h11-077, 10.1139/H11-077]
   Davidson LE, 2009, ARCH INTERN MED, V169, P122, DOI 10.1001/archinternmed.2008.558
   Davis JE, 2008, OBESITY, V16, P1248, DOI 10.1038/oby.2008.210
   de Kloet AD, 2009, ENDOCRINOLOGY, V150, P4114, DOI 10.1210/en.2009-0065
   de Zeeuw D, 2008, NAT CLIN PRACT CARD, V5, pS10, DOI 10.1038/ncpcardio1271
   DEFRONZO RA, 1987, DIABETES, V36, P1379, DOI 10.2337/diabetes.36.12.1379
   DEFRONZO RA, 1991, DIABETES CARE, V14, P173, DOI 10.2337/diacare.14.3.173
   DEFRONZO RA, 1988, DIABETES, V37, P667, DOI 10.2337/diab.37.6.667
   DELA F, 1995, DIABETES, V44, P1010, DOI 10.2337/diabetes.44.9.1010
   DELA F, 1994, DIABETES, V43, P862, DOI 10.2337/diabetes.43.7.862
   DELA F, 1993, J PHYSIOL-LONDON, V469, P615, DOI 10.1113/jphysiol.1993.sp019833
   Dela F, 2006, ESSAYS BIOCHEM, V42, P75, DOI 10.1042/bse0420075
   Dela Flemming, 1992, American Journal of Physiology, V263, pE1134, DOI 10.1152/ajpendo.2006.263.6.E1134
   Després JP, 2008, ARTERIOSCL THROM VAS, V28, P1039, DOI 10.1161/ATVBAHA.107.159228
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Devaraj S, 2009, CURR OPIN LIPIDOL, V20, P182, DOI 10.1097/MOL.0b013e32832ac03e
   Devaraj S, 2009, ATHEROSCLEROSIS, V203, P67, DOI 10.1016/j.atherosclerosis.2008.05.060
   Di Paola R, 2002, AM J HUM GENET, V70, P806, DOI 10.1086/339270
   DiPietro L, 2006, J APPL PHYSIOL, V100, P142, DOI 10.1152/japplphysiol.00474.2005
   Dobbins RL, 2001, DIABETES, V50, P123, DOI 10.2337/diabetes.50.1.123
   Dobrzyn A, 2002, AM J PHYSIOL-ENDOC M, V282, pE277, DOI 10.1152/ajpendo.00151.2001
   Donges CE, 2010, MED SCI SPORT EXER, V42, P304, DOI 10.1249/MSS.0b013e3181b117ca
   Dostálová I, 2009, PHYSIOL RES, V58, P1, DOI 10.33549/physiolres.931610
   Dubé JJ, 2008, AM J PHYSIOL-ENDOC M, V294, pE882, DOI 10.1152/ajpendo.00769.2007
   DuBose KD, 2007, PEDIATRICS, V120, pE1262, DOI 10.1542/peds.2007-0443
   DUDEK RW, 1994, FEBS LETT, V339, P205, DOI 10.1016/0014-5793(94)80416-8
   Duffaut C, 2009, ARTERIOSCL THROM VAS, V29, P1608, DOI 10.1161/ATVBAHA.109.192583
   Duffaut C, 2009, BIOCHEM BIOPH RES CO, V384, P482, DOI 10.1016/j.bbrc.2009.05.002
   Duncan GE, 2003, DIABETES CARE, V26, P557, DOI 10.2337/diacare.26.3.557
   Dunstan DW, 2002, DIABETES CARE, V25, P1729, DOI 10.2337/diacare.25.10.1729
   EBELING P, 1993, J CLIN INVEST, V92, P1623, DOI 10.1172/JCI116747
   Egawa K, 2001, J BIOL CHEM, V276, P10207, DOI 10.1074/jbc.M009489200
   Ehses JA, 2009, P NATL ACAD SCI USA, V106, P13998, DOI 10.1073/pnas.0810087106
   Ekelund U, 2005, DIABETES CARE, V28, P1195, DOI 10.2337/diacare.28.5.1195
   Elchebly M, 1999, SCIENCE, V283, P1544, DOI 10.1126/science.283.5407.1544
   Elias CF, 1999, NEURON, V23, P775, DOI 10.1016/S0896-6273(01)80035-0
   ELLIS L, 1986, P NATL ACAD SCI USA, V83, P8137, DOI 10.1073/pnas.83.21.8137
   Elmquist JK, 1999, NEURON, V22, P221, DOI 10.1016/S0896-6273(00)81084-3
   Eriksson J, 1997, DIABETOLOGIA, V40, P125
   Ernst MC, 2010, ENDOCRINOLOGY, V151, P1998, DOI 10.1210/en.2009-1098
   Evans EM, 2001, J APPL PHYSIOL, V90, P2033, DOI 10.1152/jappl.2001.90.6.2033
   Fagerholm S, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005985
   Falasca M, 2007, J BIOL CHEM, V282, P28226, DOI 10.1074/jbc.M704357200
   Farese RV, 2007, J CLIN INVEST, V117, P2289, DOI 10.1172/JCI31408
   Farese RV, 2005, BIOCHEM SOC T, V33, P350, DOI 10.1042/BST0330350
   Farrell SW, 2004, OBES RES, V12, P824, DOI 10.1038/oby.2004.99
   Febbraio MA, 2002, J PHYSIOL-LONDON, V538, P911, DOI 10.1113/jphysiol.2001.013145
   Febbraio MA, 2000, J APPL PHYSIOL, V89, P1055, DOI 10.1152/jappl.2000.89.3.1055
   Fenicchia LM, 2004, METABOLISM, V53, P284, DOI 10.1016/j.metabol.2003.10.007
   Ferder L, 2006, CURR HYPERTENS REP, V8, P191, DOI 10.1007/s11906-006-0050-7
   FERRANNINI E, 1991, DIABETOLOGIA, V34, P416, DOI 10.1007/BF00403180
   Ferrara CM, 2006, J GERONTOL A-BIOL, V61, P480, DOI 10.1093/gerona/61.5.480
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Finley CE, 2006, J AM DIET ASSOC, V106, P673, DOI 10.1016/j.jada.2006.02.012
   Fleischman A, 2008, DIABETES CARE, V31, P289, DOI 10.2337/dc07-1338
   Flores MBS, 2006, DIABETES, V55, P2554, DOI 10.2337/db05-1622
   Flynn MG, 2006, EXERC SPORT SCI REV, V34, P176, DOI 10.1249/01.jes.0000240027.22749.14
   Ford ES, 2008, DIABETES CARE, V31, P1898, DOI 10.2337/dc08-0423
   Ford ES, 2005, OBES RES, V13, P608, DOI 10.1038/oby.2005.65
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   Ford ES, 2005, DIABETES CARE, V28, P2745, DOI 10.2337/diacare.28.11.2745
   FOSTER DW, 1989, NEW ENGL J MED, V320, P733, DOI 10.1056/NEJM198903163201111
   Franks PW, 2004, DIABETES CARE, V27, P1187, DOI 10.2337/diacare.27.5.1187
   Fresno Manuel, 2011, Archives of Physiology and Biochemistry, V117, P151, DOI 10.3109/13813455.2011.562514
   FRIEDMAN JE, 1992, J CLIN INVEST, V89, P701, DOI 10.1172/JCI115638
   Friedman JM, 1998, NATURE, V395, P763, DOI 10.1038/27376
   Frosig C, 2004, AM J PHYSIOL-ENDOC M, V286, pE411, DOI 10.1152/ajpendo.00317.2003
   Frosig C, 2007, DIABETES, V56, P2093, DOI 10.2337/db06-1698
   Fruebis J, 2001, P NATL ACAD SCI USA, V98, P2005, DOI 10.1073/pnas.041591798
   Fruman DA, 1996, GENOMICS, V37, P113, DOI 10.1006/geno.1996.0527
   Fukuhara A, 2005, SCIENCE, V307, P426, DOI 10.1126/science.1097243
   Furuhashi M, 2007, NATURE, V447, P959, DOI 10.1038/nature05844
   Gaidhu MP, 2010, MOL ENDOCRINOL, V24, P1434, DOI 10.1210/me.2009-0502
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Galluzzo A, 2008, NUTR METAB CARDIOVAS, V18, P511, DOI 10.1016/j.numecd.2008.05.004
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Garvey WT, 1998, J CLIN INVEST, V101, P2377, DOI 10.1172/JCI1557
   GARVEY WT, 1992, DIABETES, V41, P465, DOI 10.2337/diabetes.41.4.465
   Geering B, 2007, BIOCHEM SOC T, V35, P199, DOI 10.1042/BST0350199
   Gleeson M, 2011, NAT REV IMMUNOL, V11, P607, DOI 10.1038/nri3041
   Goldfine AB, 2008, CTS-CLIN TRANSL SCI, V1, P36, DOI 10.1111/j.1752-8062.2008.00026.x
   Goldstein BJ, 2005, ANTIOXID REDOX SIGN, V7, P1021, DOI 10.1089/ars.2005.7.1021
   Goodpaster BH, 2003, DIABETES, V52, P2191, DOI 10.2337/diabetes.52.9.2191
   Goodpaster BH, 2001, J CLIN ENDOCR METAB, V86, P5755, DOI 10.1210/jc.86.12.5755
   Goodyear LJ, 2008, NEW ENGL J MED, V359, P1842, DOI 10.1056/NEJMcibr0806723
   Goossens GH, 2008, PHYSIOL BEHAV, V94, P206, DOI 10.1016/j.physbeh.2007.10.010
   Goralski KB, 2007, J BIOL CHEM, V282, P28175, DOI 10.1074/jbc.M700793200
   Gordon BA, 2009, DIABETES RES CLIN PR, V83, P157, DOI 10.1016/j.diabres.2008.11.024
   Gordon S, 2010, IMMUNITY, V32, P593, DOI 10.1016/j.immuni.2010.05.007
   Gotto AM, 2006, CORONARY ARTERY DIS, V17, P77, DOI 10.1097/00019501-200602000-00013
   Graham TE, 2006, NEW ENGL J MED, V354, P2552, DOI 10.1056/NEJMoa054862
   Gregor MF, 2007, J LIPID RES, V48, P1905, DOI 10.1194/jlr.R700007-JLR200
   Gregor MF, 2009, DIABETES, V58, P693, DOI 10.2337/db08-1220
   GRIMDITCH GK, 1987, AM J PHYSIOL, V252, pE420, DOI 10.1152/ajpendo.1987.252.3.E420
   GRIMDITCH GK, 1988, AM J CLIN NUTR, V48, P38, DOI 10.1093/ajcn/48.1.38
   Grundy SM, 2005, CLIN CHEM, V51, P1352, DOI 10.1373/clinchem.2005.050989
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Gum RJ, 2003, DIABETES, V52, P21, DOI 10.2337/diabetes.52.1.21
   Guo S, 2009, MOL CELL BIOL, V29, P5070, DOI 10.1128/MCB.00138-09
   Gupte AA, 2011, J APPL PHYSIOL, V110, P451, DOI 10.1152/japplphysiol.00849.2010
   Gupte AA, 2009, DIABETES, V58, P567, DOI 10.2337/db08-1070
   GUSTAFSON TA, 1995, MOL CELL BIOL, V15, P2500
   Gustavsson J, 1999, FASEB J, V13, P1961, DOI 10.1096/fasebj.13.14.1961
   HAFFNER SM, 1991, INT J OBESITY, V15, P471
   HAFFNER SM, 1992, DIABETES, V41, P715, DOI 10.2337/diabetes.41.6.715
   Haider DG, 2006, AM J PHYSIOL-ENDOC M, V291, pE885, DOI 10.1152/ajpendo.00109.2006
   Halldin M, 2007, NUTR METAB CARDIOVAS, V17, P349, DOI 10.1016/j.numecd.2006.01.002
   Hamaguchi M, 2005, ANN INTERN MED, V143, P722, DOI 10.7326/0003-4819-143-10-200511150-00009
   Han DH, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019739
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   HANSEN PA, 1995, J BIOL CHEM, V270, P1679
   Hara K, 2002, DIABETES, V51, P536, DOI 10.2337/diabetes.51.2.536
   Hassinen M, 2008, DIABETES CARE, V31, P1242, DOI 10.2337/dc07-2298
   Haunerland NH, 2004, PROG LIPID RES, V43, P328, DOI 10.1016/j.plipres.2004.05.001
   Hawley JA, 2009, NUTR REV, V67, P172, DOI 10.1111/j.1753-4887.2009.00185.x
   Healy GN, 2007, DIABETES CARE, V30, P1384, DOI 10.2337/dc07-0114
   HEATH GW, 1983, J APPL PHYSIOL, V55, P512, DOI 10.1152/jappl.1983.55.2.512
   Heffernan KS, 2009, AM J PHYSIOL-REG I, V296, pR1098, DOI 10.1152/ajpregu.90936.2008
   Hein TW, 2009, ATHEROSCLEROSIS, V206, P61, DOI 10.1016/j.atherosclerosis.2009.02.002
   Heitmeier MR, 2001, J BIOL CHEM, V276, P11151, DOI 10.1074/jbc.M009159200
   Helge JW, 2004, EXP PHYSIOL, V89, P119, DOI 10.1113/expphysiol.2003.002605
   Helledie T, 2000, J LIPID RES, V41, P1740
   Hevener AL, 2007, J CLIN INVEST, V117, P1658, DOI 10.1172/JCI31561
   Higaki Y, 1999, J BIOL CHEM, V274, P20791, DOI 10.1074/jbc.274.30.20791
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Hojman P, 2011, AM J PHYSIOL-ENDOC M, V301, pE504, DOI 10.1152/ajpendo.00520.2010
   Holland WL, 2008, ENDOCR REV, V29, P381, DOI 10.1210/er.2007-0025
   Holland WL, 2007, CELL METAB, V5, P167, DOI 10.1016/j.cmet.2007.01.002
   HOLLENBECK CB, 1985, J AM GERIATR SOC, V33, P273, DOI 10.1111/j.1532-5415.1985.tb07116.x
   Holloway GP, 2011, DIABETOLOGIA, V54, P1457, DOI 10.1007/s00125-011-2114-8
   Holme I, 2007, BMC PUBLIC HEALTH, V7, DOI 10.1186/1471-2458-7-154
   Holten MK, 2004, DIABETES, V53, P294, DOI 10.2337/diabetes.53.2.294
   Hood MS, 2011, MED SCI SPORT EXER, V43, P1849, DOI 10.1249/MSS.0b013e3182199834
   Hopps E, 2011, ACTA DIABETOL, V48, P183, DOI 10.1007/s00592-011-0278-9
   Hori H, 2002, DIABETES, V51, P2387, DOI 10.2337/diabetes.51.8.2387
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   Hotamisligil GS, 1999, J INTERN MED, V245, P621, DOI 10.1046/j.1365-2796.1999.00490.x
   Hotamisligil GS, 1996, SCIENCE, V271, P665, DOI 10.1126/science.271.5249.665
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   HOTAMISLIGIL GS, 1995, J CLIN INVEST, V95, P2409, DOI 10.1172/JCI117936
   HOTAMISLIGIL GS, 1994, J CLIN INVEST, V94, P1543, DOI 10.1172/JCI117495
   HOUMARD JA, 1993, J APPL PHYSIOL, V74, P776, DOI 10.1152/jappl.1993.74.2.776
   Houmard JA, 2004, J APPL PHYSIOL, V96, P101, DOI 10.1152/japplphysiol.00707.2003
   Houmard JA, 1996, J APPL PHYSIOL, V81, P1162, DOI 10.1152/jappl.1996.81.3.1162
   HOUMARD JA, 1993, AM J PHYSIOL, V264, pE896, DOI 10.1152/ajpendo.1993.264.6.E896
   HOUMARD JA, 1991, AM J PHYSIOL, V261, pE437, DOI 10.1152/ajpendo.1991.261.4.E437
   Houmard JA, 1999, AM J PHYSIOL-ENDOC M, V277, pE1055, DOI 10.1152/ajpendo.1999.277.6.E1055
   Howard JK, 2004, NAT MED, V10, P734, DOI 10.1038/nm1072
   Hu E, 1996, J BIOL CHEM, V271, P10697, DOI 10.1074/jbc.271.18.10697
   Huang CJ, 2007, DIABETES, V56, P2016, DOI 10.2337/db07-0197
   Hubbard SR, 1997, EMBO J, V16, P5572, DOI 10.1093/emboj/16.18.5572
   HUBBARD SR, 1994, NATURE, V372, P746, DOI 10.1038/372746a0
   Huber J, 2008, J CLIN ENDOCR METAB, V93, P3215, DOI 10.1210/jc.2007-2630
   Huber K, 2001, J THROMB THROMBOLYS, V11, P195, DOI 10.1023/A:1011952602122
   HUGHES VA, 1993, AM J PHYSIOL, V264, pE855, DOI 10.1152/ajpendo.1993.264.6.E855
   Hung J, 2008, INT J OBESITY, V32, P772, DOI 10.1038/sj.ijo.0803793
   HURLEY BF, 1988, MED SCI SPORT EXER, V20, P150, DOI 10.1249/00005768-198820020-00008
   Ibañez J, 2005, DIABETES CARE, V28, P662, DOI 10.2337/diacare.28.3.662
   Ilanne-Parikka P, 2008, DIABETES CARE, V31, P805, DOI 10.2337/dc07-1117
   Ilanne-Parikka P, 2010, DIABETES CARE, V33, P1610, DOI 10.2337/dc09-2155
   Irwin ML, 2002, OBES RES, V10, P1030, DOI 10.1038/oby.2002.140
   Ishihara H, 2003, FEBS LETT, V554, P450, DOI 10.1016/S0014-5793(03)01225-0
   Ishii T, 1998, DIABETES CARE, V21, P1353, DOI 10.2337/diacare.21.8.1353
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Itani SI, 2002, DIABETES, V51, P2005, DOI 10.2337/diabetes.51.7.2005
   Izumiya Y, 2008, FEBS LETT, V582, P3805, DOI 10.1016/j.febslet.2008.10.021
   Jackevicius CA, 2002, JAMA-J AM MED ASSOC, V288, P462, DOI 10.1001/jama.288.4.462
   Jacob S, 1999, DIABETES, V48, P1113, DOI 10.2337/diabetes.48.5.1113
   Jebailey L, 2004, MOL ENDOCRINOL, V18, P359, DOI 10.1210/me.2003-0294
   Jeppesen J, 2010, J LIPID RES, V51, P1504, DOI 10.1194/jlr.M003756
   Johnson JL, 2007, AM J CARDIOL, V100, P1759, DOI 10.1016/j.amjcard.2007.07.027
   Joost HG, 2001, MOL MEMBR BIOL, V18, P247, DOI 10.1080/09687680110090456
   Jung HS, 2006, CARDIOVASC RES, V69, P76, DOI 10.1016/j.cardiores.2005.09.015
   Jurca R, 2005, MED SCI SPORT EXER, V37, P1849, DOI 10.1249/01.mss.0000175865.17614.74
   Jurca R, 2004, MED SCI SPORT EXER, V36, P1301, DOI 10.1249/01.MSS.0000135780.88930.A9
   KABURAGI Y, 1995, ENDOCRINOLOGY, V136, P3437, DOI 10.1210/en.136.8.3437
   Kaczocha M, 2012, J BIOL CHEM, V287, P3415, DOI 10.1074/jbc.M111.304907
   Kadowaki T, 2005, ENDOCR REV, V26, P439, DOI 10.1210/er.2005-0005
   Kadowaki T, 2006, J CLIN INVEST, V116, P1784, DOI 10.1172/JCI29126
   Kagawa S, 2008, ENDOCRINOLOGY, V149, P642, DOI 10.1210/en.2007-0820
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   Kalmijn S, 2000, ARTERIOSCL THROM VAS, V20, P2255, DOI 10.1161/01.ATV.20.10.2255
   Kamei N, 2006, J BIOL CHEM, V281, P26602, DOI 10.1074/jbc.M601284200
   Kanda H, 2006, J CLIN INVEST, V116, P1494, DOI 10.1172/JCI26498
   Kane S, 2002, J BIOL CHEM, V277, P22115, DOI 10.1074/jbc.C200198200
   Kanzaki M, 2004, J CELL BIOL, V164, P279, DOI 10.1083/jcb.200306152
   Kanzaki M, 2001, J BIOL CHEM, V276, P49331, DOI 10.1074/jbc.M109657200
   KAPLAN NM, 1989, ARCH INTERN MED, V149, P1514, DOI 10.1001/archinte.149.7.1514
   Karlsson HKR, 2005, DIABETES, V54, P1692, DOI 10.2337/diabetes.54.6.1692
   Kasapis C, 2005, J AM COLL CARDIOL, V45, P1563, DOI 10.1016/j.jacc.2004.12.077
   KATZ EB, 1995, NATURE, V377, P151, DOI 10.1038/377151a0
   Katzmarzyk PT, 2006, DIABETES CARE, V29, P404, DOI 10.2337/diacare.29.02.06.dc05-1636
   Katzmarzyk PT, 2005, DIABETES CARE, V28, P391, DOI 10.2337/diacare.28.2.391
   Katzmarzyk PT, 2004, ARCH INTERN MED, V164, P1092, DOI 10.1001/archinte.164.10.1092
   Katzmarzyk PT, 2003, MED SCI SPORT EXER, V35, P1703, DOI 10.1249/01.MSS.0000089337.73244.9B
   Kaur J, 2010, BIOCHEM BIOPH RES CO, V391, P1762, DOI 10.1016/j.bbrc.2009.12.150
   KAVANAUGH WM, 1994, SCIENCE, V266, P1862, DOI 10.1126/science.7527937
   Kawamoto R, 2008, INTERNAL MED, V47, P1399, DOI 10.2169/internalmedicine.47.1202
   Kawanishi N, 2010, EXERC IMMUNOL REV, V16, P105
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Kelly KR, 2012, MED SCI SPORT EXER, V44, P69, DOI 10.1249/MSS.0b013e318228bf85
   Kemmler W, 2009, MED SCI SPORT EXER, V41, P297, DOI 10.1249/MSS.0b013e31818844b7
   Khan AH, 2004, J BIOL CHEM, V279, P37505, DOI 10.1074/jbc.M405694200
   Kharitonenkov A, 2005, J CLIN INVEST, V115, P1627, DOI 10.1172/JCI23606
   Kiens B, 1997, BIOCHEM BIOPH RES CO, V231, P463, DOI 10.1006/bbrc.1997.6118
   Kim JY, 2000, AM J PHYSIOL-ENDOC M, V279, pE1039, DOI 10.1152/ajpendo.2000.279.5.E1039
   KING DS, 1988, J APPL PHYSIOL, V64, P1942, DOI 10.1152/jappl.1988.64.5.1942
   KING DS, 1987, J APPL PHYSIOL, V63, P2247, DOI 10.1152/jappl.1987.63.6.2247
   Kirchgessner TG, 1997, J CLIN INVEST, V100, P2777, DOI 10.1172/JCI119824
   Kirwan JP, 2009, AM J PHYSIOL-ENDOC M, V297, pE151, DOI 10.1152/ajpendo.00210.2009
   Kirwan JP, 2000, J APPL PHYSIOL, V88, P797, DOI 10.1152/jappl.2000.88.2.797
   Klaman LD, 2000, MOL CELL BIOL, V20, P5479, DOI 10.1128/MCB.20.15.5479-5489.2000
   Klein BEK, 2002, DIABETES CARE, V25, P1790, DOI 10.2337/diacare.25.10.1790
   Klimcakova E, 2006, J CLIN ENDOCR METAB, V91, P5107, DOI 10.1210/jc.2006-0382
   Klover PJ, 2003, DIABETES, V52, P2784, DOI 10.2337/diabetes.52.11.2784
   Knudsen SH, 2012, J APPL PHYSIOL, V113, P7, DOI 10.1152/japplphysiol.00189.2011
   Koren S, 2007, BEST PRACT RES CL EN, V21, P621, DOI 10.1016/j.beem.2007.08.004
   Kotani K, 1998, MOL CELL BIOL, V18, P6971, DOI 10.1128/MCB.18.12.6971
   Kováciková M, 2011, INT J OBESITY, V35, P91, DOI 10.1038/ijo.2010.112
   Krabbe KS, 2007, DIABETOLOGIA, V50, P431, DOI 10.1007/s00125-006-0537-4
   Kramer HF, 2006, J BIOL CHEM, V281, P31478, DOI 10.1074/jbc.M605461200
   Kressel G, 2009, ATHEROSCLEROSIS, V202, P263, DOI 10.1016/j.atherosclerosis.2008.04.012
   Krisan AD, 2004, J APPL PHYSIOL, V96, P1691, DOI 10.1152/japplphysiol.01054.2003
   Kriska AM, 2001, DIABETES CARE, V24, P1175, DOI 10.2337/diacare.24.7.1175
   Krogh-Madsen R, 2010, J APPL PHYSIOL, V108, P1034, DOI 10.1152/japplphysiol.00977.2009
   Krssak M, 1999, DIABETOLOGIA, V42, P113, DOI 10.1007/s001250051123
   Kubota N, 2002, J BIOL CHEM, V277, P25863, DOI 10.1074/jbc.C200251200
   Kurlawalla-Martinez C, 2005, MOL CELL BIOL, V25, P2498, DOI 10.1128/MCB.25.6.2498-2510.2005
   Laaksonen DE, 2002, DIABETES CARE, V25, P1612, DOI 10.2337/diacare.25.9.1612
   Lacraz G, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006963
   Lagathu C, 2003, BIOCHEM BIOPH RES CO, V311, P372, DOI 10.1016/j.bbrc.2003.10.013
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lakka TA, 2003, MED SCI SPORT EXER, V35, P1279, DOI 10.1249/01.MSS.0000079076.74931.9A
   LaMonte MJ, 2005, CIRCULATION, V112, P505, DOI 10.1161/CIRCULATIONAHA.104.503805
   LANDIN K, 1990, J INTERN MED, V227, P273, DOI 10.1111/j.1365-2796.1990.tb00157.x
   Landsberg L, 2008, ARCH INTERN MED, V168, P1607, DOI 10.1001/archinte.168.15.1607
   Lang CH, 2003, SHOCK, V19, P538, DOI 10.1097/01.shk.0000055237.25446.80
   Larance M, 2008, MOL ENDOCRINOL, V22, P226, DOI 10.1210/me.2007-0282
   Larsen J, 2002, BRIT J CLIN PHARMACO, V53, P375, DOI 10.1046/j.1365-2125.2002.01563.x
   Laybutt DR, 2007, DIABETOLOGIA, V50, P752, DOI 10.1007/s00125-006-0590-z
   Lazar DF, 2006, NAT REV DRUG DISCOV, V5, P333, DOI 10.1038/nrd2007
   LEBLANC J, 1979, J APPL PHYSIOL, V46, P235, DOI 10.1152/jappl.1979.46.2.235
   LEBLANC J, 1981, METABOLISM, V30, P1119, DOI 10.1016/0026-0495(81)90057-3
   Lee GH, 1996, NATURE, V379, P632, DOI 10.1038/379632a0
   Lee JM, 2010, J INT MED RES, V38, P234, DOI 10.1177/147323001003800128
   Lee J, 2010, EUR J APPL PHYSIOL, V108, P633, DOI 10.1007/s00421-009-1251-y
   LEE JS, 1993, J BIOL CHEM, V268, P4092
   LEE JS, 1994, AM J PHYSIOL, V266, pC319, DOI 10.1152/ajpcell.1994.266.2.C319
   Leiter LA, 2005, AM J HYPERTENS, V18, P121, DOI 10.1016/j.amjhyper.2004.07.001
   Lemieux I, 2001, ARTERIOSCL THROM VAS, V21, P961, DOI 10.1161/01.ATV.21.6.961
   Levin BE, 2004, AM J PHYSIOL-REG I, V286, pR143, DOI 10.1152/ajpregu.00393.2003
   Li J, 1997, SCIENCE, V275, P1943, DOI 10.1126/science.275.5308.1943
   Liao YL, 2004, DIABETES CARE, V27, P978, DOI 10.2337/diacare.27.4.978
   Lin Y, 2000, J BIOL CHEM, V275, P24255, DOI 10.1074/jbc.M002137200
   Little JP, 2011, J APPL PHYSIOL, V111, P1554, DOI 10.1152/japplphysiol.00921.2011
   Little JP, 2010, J PHYSIOL-LONDON, V588, P1011, DOI 10.1113/jphysiol.2009.181743
   Liu G, 2005, AM J PHYSIOL-ENDOC M, V289, pE746, DOI 10.1152/ajpendo.00175.2005
   Liu J, 2002, MOL CELL BIOL, V22, P3599, DOI 10.1128/MCB.22.11.3599-3609.2002
   Loh K, 2009, CELL METAB, V10, P260, DOI 10.1016/j.cmet.2009.08.009
   LOHMANN D, 1978, METABOLISM, V27, P521, DOI 10.1016/0026-0495(78)90017-3
   Luiken JJFP, 2002, AM J PHYSIOL-ENDOC M, V282, pE491, DOI 10.1152/ajpendo.00419.2001
   Luiken JJFP, 2001, J BIOL CHEM, V276, P40567, DOI 10.1074/jbc.M100052200
   Luotola K, 2009, J CLIN ENDOCR METAB, V94, P4575, DOI 10.1210/jc.2009-0666
   Ma LJ, 2004, DIABETES, V53, P336, DOI 10.2337/diabetes.53.2.336
   MacDougall JD, 1998, J APPL PHYSIOL, V84, P2138, DOI 10.1152/jappl.1998.84.6.2138
   Maeda K, 2005, CELL METAB, V1, P107, DOI 10.1016/j.cmet.2004.12.008
   Maeda N, 2002, NAT MED, V8, P731, DOI 10.1038/nm724
   Maedler K, 2004, P NATL ACAD SCI USA, V101, P8138, DOI 10.1073/pnas.0305683101
   Maedler K, 2009, EXPERT OPIN BIOL TH, V9, P1177, DOI 10.1517/14712590903136688
   Magnussen CG, 2010, CIRCULATION, V122, P1604, DOI 10.1161/CIRCULATIONAHA.110.940809
   Mahadev K, 2001, J BIOL CHEM, V276, P48662, DOI 10.1074/jbc.M105061200
   Mahadev K, 2001, J BIOL CHEM, V276, P21938, DOI 10.1074/jbc.C100109200
   Mao XM, 2006, NAT CELL BIOL, V8, P516, DOI 10.1038/ncb1404
   Massiéra F, 2001, FASEB J, V15, P2727, DOI 10.1096/fj.01-0457fje
   Matsubara Y, 2009, ANN NUTR METAB, V54, P258, DOI 10.1159/000229506
   Matsuda M, 1999, DIABETES CARE, V22, P1462, DOI 10.2337/diacare.22.9.1462
   Matsumoto M, 2003, J CLIN INVEST, V112, P935, DOI 10.1172/JCI200318816
   Matthews VB, 2010, DIABETOLOGIA, V53, P2431, DOI 10.1007/s00125-010-1865-y
   Matthews VB, 2009, DIABETOLOGIA, V52, P1409, DOI 10.1007/s00125-009-1364-1
   Mauvais-Jarvis F, 2002, J CLIN INVEST, V109, P141, DOI 10.1172/JCI13305
   Mayer-Davis EJ, 1998, JAMA-J AM MED ASSOC, V279, P669, DOI 10.1001/jama.279.9.669
   McGettrick AJ, 2005, J BIOL CHEM, V280, P6441, DOI 10.1074/jbc.M412300200
   Méndez-Hernández P, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-276
   Menzaghi C, 2007, DIABETES, V56, P1198, DOI 10.2337/db06-0506
   MIKINES KJ, 1989, AM J PHYSIOL, V257, pE43, DOI 10.1152/ajpendo.1989.257.1.E43
   MIKINES KJ, 1989, J APPL PHYSIOL, V66, P695, DOI 10.1152/jappl.1989.66.2.695
   MIKINES KJ, 1989, AM J PHYSIOL, V256, pE588, DOI 10.1152/ajpendo.1989.256.5.E588
   MIKINES KJ, 1988, AM J PHYSIOL, V254, pE248, DOI 10.1152/ajpendo.1988.254.3.E248
   MIKINES KJ, 1992, ACTA PHYSIOL SCAND, V146, P1
   MIKINES KJ, 1989, J APPL PHYSIOL, V66, P704, DOI 10.1152/jappl.1989.66.2.704
   MIKINES KJ, 1991, J APPL PHYSIOL, V70, P1245, DOI 10.1152/jappl.1991.70.3.1245
   Mikus CR, 2012, DIABETOLOGIA, V55, P1417, DOI 10.1007/s00125-012-2490-8
   Mikus CR, 2012, MED SCI SPORT EXER, V44, P225, DOI 10.1249/MSS.0b013e31822ac0c0
   MILLER JP, 1994, J APPL PHYSIOL, V77, P1122, DOI 10.1152/jappl.1994.77.3.1122
   MILLER WJ, 1984, MED SCI SPORT EXER, V16, P539
   Mills PJ, 2006, J APPL PHYSIOL, V101, P785, DOI 10.1152/japplphysiol.00135.2006
   Min J, 1999, MOL CELL, V3, P751, DOI 10.1016/S1097-2765(01)80007-1
   Min L, 2007, J BIOL CHEM, V282, P33530, DOI 10.1074/jbc.M703402200
   Minoura H, 2007, DIABETES OBES METAB, V9, P369, DOI 10.1111/j.1463-1326.2006.00619.x
   Misra A, 2008, DIABETES CARE, V31, P1282, DOI 10.2337/dc07-2316
   Moller DE, 2000, TRENDS ENDOCRIN MET, V11, P212, DOI 10.1016/S1043-2760(00)00272-1
   Monzavi R, 2006, PEDIATRICS, V117, pE1111, DOI 10.1542/peds.2005-1532
   Moore JB, 2010, P NUTR SOC, V69, P211, DOI 10.1017/S0029665110000030
   Mootha VK, 2004, P NATL ACAD SCI USA, V101, P6570, DOI 10.1073/pnas.0401401101
   Mori H, 2004, NAT MED, V10, P739, DOI 10.1038/nm1071
   Morris MJ, 2008, INT J OBESITY, V32, P249, DOI 10.1038/sj.ijo.0803716
   Morrison J A, 2008, Minerva Med, V99, P269
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Murata Y, 2007, BIOCHEM BIOPH RES CO, V364, P301, DOI 10.1016/j.bbrc.2007.10.007
   Murray I, 1999, AM J PHYSIOL-ENDOC M, V277, pE474, DOI 10.1152/ajpendo.1999.277.3.E474
   Murray I, 2000, ENDOCRINOLOGY, V141, P1041, DOI 10.1210/en.141.3.1041
   MUSCARI A, 1990, ATHEROSCLEROSIS, V81, P111, DOI 10.1016/0021-9150(90)90017-D
   Muse ED, 2004, J CLIN INVEST, V114, P232, DOI 10.1172/JCI200421270
   MYERS MG, 1995, J BIOL CHEM, V270, P11715, DOI 10.1074/jbc.270.20.11715
   Nassis GP, 2005, METABOLISM, V54, P1472, DOI 10.1016/j.metabol.2005.05.013
   Nieto-Vazquez I, 2007, DIABETES, V56, P404, DOI 10.2337/db06-0989
   Nishimura S, 2009, NAT MED, V15, P914, DOI 10.1038/nm.1964
   Niu WY, 2011, J CELL PHYSIOL, V226, P173, DOI 10.1002/jcp.22320
   Nollen EAA, 2002, J CELL SCI, V115, P2809
   Norheim F, 2011, AM J PHYSIOL-ENDOC M, V301, pE1013, DOI 10.1152/ajpendo.00326.2011
   Norquay LD, 2009, ENDOCRINOLOGY, V150, P4531, DOI 10.1210/en.2009-0395
   Odegaard JI, 2007, NATURE, V447, P1116, DOI 10.1038/nature05894
   Öhman MK, 2010, ARTERIOSCL THROM VAS, V30, P1151, DOI 10.1161/ATVBAHA.110.205914
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Ofei F, 1996, DIABETES, V45, P881, DOI 10.2337/diabetes.45.7.881
   Ohmori R, 2005, J AM COLL CARDIOL, V46, P379, DOI 10.1016/j.jacc.2005.04.022
   Ohmura K, 2010, ARTERIOSCL THROM VAS, V30, P193, DOI 10.1161/ATVBAHA.109.198614
   Okura T, 2007, OBESITY, V15, P2478, DOI 10.1038/oby.2007.294
   OLD LJ, 1985, SCIENCE, V230, P630, DOI 10.1126/science.2413547
   Olsen RH, 2008, JAMA-J AM MED ASSOC, V299, P1261, DOI 10.1001/jama.299.11.1259
   Olson TP, 2007, INT J OBESITY, V31, P996, DOI 10.1038/sj.ijo.0803534
   ONEILL TJ, 1994, MOL CELL BIOL, V14, P6433, DOI 10.1128/MCB.14.10.6433
   Orchard TJ, 2005, ANN INTERN MED, V142, P611, DOI 10.7326/0003-4819-142-8-200504190-00009
   Osawa H, 2004, AM J HUM GENET, V75, P678, DOI 10.1086/424761
   OSHIDA Y, 1991, INT J SPORTS MED, V12, P484, DOI 10.1055/s-2007-1024718
   OSHIDA Y, 1989, J APPL PHYSIOL, V66, P2206, DOI 10.1152/jappl.1989.66.5.2206
   Oshima Y, 2008, CIRCULATION, V117, P3099, DOI 10.1161/CIRCULATIONAHA.108.767673
   Ostergård T, 2006, AM J PHYSIOL-ENDOC M, V290, pE998, DOI 10.1152/ajpendo.00012.2005
   Ouchi N, 2008, J BIOL CHEM, V283, P32802, DOI 10.1074/jbc.M803440200
   Owyang AM, 2010, ENDOCRINOLOGY, V151, P2515, DOI 10.1210/en.2009-1124
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Patel L, 2003, BIOCHEM BIOPH RES CO, V300, P472, DOI 10.1016/S0006-291X(02)02841-3
   Patti ME, 2003, P NATL ACAD SCI USA, V100, P8466, DOI 10.1073/pnas.1032913100
   Pearce LR, 2010, NAT REV MOL CELL BIO, V11, P9, DOI 10.1038/nrm2822
   Pedersen BK, 2008, PHYSIOL REV, V88, P1379, DOI 10.1152/physrev.90100.2007
   Pedersen BK, 2005, BRAIN BEHAV IMMUN, V19, P371, DOI 10.1016/j.bbi.2005.04.008
   Pedersen BK, 2003, PFLUG ARCH EUR J PHY, V446, P9, DOI 10.1007/s00424-002-0981-z
   Pederson TM, 2001, DIABETES, V50, P24, DOI 10.2337/diabetes.50.1.24
   PEETERS RA, 1991, BIOCHEM J, V276, P203, DOI 10.1042/bj2760203
   Pellmé F, 2003, DIABETES, V52, P1182, DOI 10.2337/diabetes.52.5.1182
   Perseghin G, 1999, DIABETES, V48, P1600, DOI 10.2337/diabetes.48.8.1600
   Perseghin G, 1996, NEW ENGL J MED, V335, P1357, DOI 10.1056/NEJM199610313351804
   Pessin JE, 2000, J CLIN INVEST, V106, P165, DOI 10.1172/JCI10582
   [Anonymous], DIABETOLOGIA
   [Anonymous], MED SCI SPORTS EXERC
   [Anonymous], PRESSE MED
   Pessin JE, 1999, J BIOL CHEM, V274, P2593, DOI 10.1074/jbc.274.5.2593
   Petersen AMW, 2005, J APPL PHYSIOL, V98, P1154, DOI 10.1152/japplphysiol.00164.2004
   Petersen KF, 2004, NEW ENGL J MED, V350, P664, DOI 10.1056/NEJMoa031314
   Pischon T, 2004, JAMA-J AM MED ASSOC, V291, P1730, DOI 10.1001/jama.291.14.1730
   Pitsavos C, 2005, EUR J CARDIOV PREV R, V12, P151, DOI 10.1097/00149831-200504000-00010
   Poehlman ET, 2000, J CLIN ENDOCR METAB, V85, P2463, DOI 10.1210/jc.85.7.2463
   Polak J, 2005, DIABETOLOGIA, V48, P2631, DOI 10.1007/s00125-005-0003-8
   Poltorak A, 1998, BLOOD CELL MOL DIS, V24, P340, DOI 10.1006/bcmd.1998.0201
   Pomeroy C, 1997, CLIN EXP IMMUNOL, V108, P507, DOI 10.1046/j.1365-2249.1997.3921287.x
   Potashnik R, 2003, DIABETOLOGIA, V46, P639, DOI 10.1007/s00125-003-1097-5
   Previs SF, 2000, J BIOL CHEM, V275, P38990, DOI 10.1074/jbc.M006490200
   Prodi E, 2006, ENDOCRINOLOGY, V147, P2664, DOI 10.1210/en.2006-0143
   Qi L, 2007, J CLIN ENDOCR METAB, V92, P3618, DOI 10.1210/jc.2007-0877
   Quinn LS, 2009, AM J PHYSIOL-ENDOC M, V296, pE191, DOI 10.1152/ajpendo.90506.2008
   Rabe B, 2008, BLOOD, V111, P1021, DOI 10.1182/blood-2007-07-102137
   Rajala MW, 2004, DIABETES, V53, P1671, DOI 10.2337/diabetes.53.7.1671
   Rana JS, 2006, INT J CARDIOL, V110, P224, DOI 10.1016/j.ijcard.2005.08.040
   RANDLE PJ, 1963, LANCET, V1, P785
   Rangwala SM, 2004, DIABETES, V53, P1937, DOI 10.2337/diabetes.53.8.1937
   Rasmussen P, 2009, EXP PHYSIOL, V94, P1062, DOI 10.1113/expphysiol.2009.048512
   Rasouli N, 2008, J CLIN ENDOCR METAB, V93, pS64, DOI 10.1210/jc.2008-1613
   Reaven GM, 2006, AM J CLIN NUTR, V83, P1237, DOI 10.1093/ajcn/83.6.1237
   Reaven GM, 2005, CLIN CHEM, V51, P931, DOI 10.1373/clinchem.2005.048611
   REAVEN GM, 1993, J CLIN INVEST, V92, P141, DOI 10.1172/JCI116541
   Reaven GM, 2004, DIABETES CARE, V27, P1011, DOI 10.2337/diacare.27.4.1011
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   REAVEN GM, 1979, J LIPID RES, V20, P371
   Reil TD, 1999, J SURG RES, V85, P96, DOI 10.1006/jsre.1999.5666
   Reilly MP, 2005, CIRCULATION, V111, P932, DOI 10.1161/01.CIR.0000155620.10387.43
   Reinehr T, 2009, ATHEROSCLEROSIS, V207, P174, DOI 10.1016/j.atherosclerosis.2009.03.041
   REN JM, 1995, J CLIN INVEST, V95, P429, DOI 10.1172/JCI117673
   Rennie KL, 2003, INT J EPIDEMIOL, V32, P600, DOI 10.1093/ije/dyg179
   Ress C, 2010, EUR J CLIN INVEST, V40, P277, DOI 10.1111/j.1365-2362.2010.02255.x
   Retnakaran R, 2008, OBESITY, V16, P1901, DOI 10.1038/oby.2008.307
   Rewers M, 2004, DIABETES CARE, V27, P781, DOI 10.2337/diacare.27.3.781
   Reynolds TH, 2004, METABOLISM, V53, P397, DOI 10.1016/j.metabol.2003.09.017
   Reynolds TH, 2007, J APPL PHYSIOL, V102, P985, DOI 10.1152/japplphysiol.00914.2006
   Ribas V, 2011, P NATL ACAD SCI USA, V108, P16457, DOI 10.1073/pnas.1104533108
   Richards JC, 2010, J PHYSIOL-LONDON, V588, P2961, DOI 10.1113/jphysiol.2010.189886
   Richter EA, 2008, CELL METAB, V8, P96, DOI 10.1016/j.cmet.2008.07.004
   Ritov VB, 2005, DIABETES, V54, P8, DOI 10.2337/diabetes.54.1.8
   Roberts CK, 2006, J APPL PHYSIOL, V101, P1727, DOI 10.1152/japplphysiol.00345.2006
   Roberts CK, 2001, HYPERTENSION, V37, P1323, DOI 10.1161/01.HYP.37.5.1323
   Roepstorff C, 2002, AM J PHYSIOL-ENDOC M, V282, pE435, DOI 10.1152/ajpendo.00266.2001
   ROGERS MA, 1990, J APPL PHYSIOL, V68, P1833, DOI 10.1152/jappl.1990.68.5.1833
   Roh SG, 2007, BIOCHEM BIOPH RES CO, V362, P1013, DOI 10.1016/j.bbrc.2007.08.104
   Ronti T, 2006, CLIN ENDOCRINOL, V64, P355, DOI 10.1111/j.1365-2265.2006.02474.x
   Ropelle ER, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003856
   Ropelle ER, 2006, J PHYSIOL-LONDON, V577, P997, DOI 10.1113/jphysiol.2006.120006
   Rose-John S, 2006, J LEUKOCYTE BIOL, V80, P227, DOI 10.1189/jlb.1105674
   ROSEN OM, 1983, P NATL ACAD SCI-BIOL, V80, P3237, DOI 10.1073/pnas.80.11.3237
   Ross A, 2001, SPORTS MED, V31, P1063, DOI 10.2165/00007256-200131150-00003
   Ross R, 2002, AM J PHYSIOL-ENDOC M, V282, pE657, DOI 10.1152/ajpendo.00469.2001
   Rotter V, 2003, J BIOL CHEM, V278, P45777, DOI 10.1074/jbc.M301977200
   Rui LY, 2001, J CLIN INVEST, V107, P181, DOI 10.1172/JCI10934
   Russell AP, 2004, INT J OBESITY, V28, pS66, DOI 10.1038/sj.ijo.0802859
   Ryan AS, 2001, J AM GERIATR SOC, V49, P247, DOI 10.1046/j.1532-5415.2001.4930247.x
   Ryan AS, 1996, J GERONTOL A-BIOL, V51, pM199, DOI 10.1093/gerona/51A.5.M199
   Saberi M, 2009, CELL METAB, V10, P419, DOI 10.1016/j.cmet.2009.09.006
   Sajan MP, 2004, MOL ENDOCRINOL, V18, P2513, DOI 10.1210/me.2004-0045
   Saleh J, 2001, INT J OBESITY, V25, P705, DOI 10.1038/sj.ijo.0801613
   Saltevo J, 2007, MEDIAT INFLAMM, V2007, DOI 10.1155/2007/93573
   Saltiel AR, 2003, TRAFFIC, V4, P711, DOI 10.1034/j.1600-0854.2003.00119.x
   Sano H, 2003, J BIOL CHEM, V278, P14599, DOI 10.1074/jbc.C300063200
   Santos AC, 2007, PREV MED, V44, P328, DOI 10.1016/j.ypmed.2006.11.016
   Sartipy P, 2003, P NATL ACAD SCI USA, V100, P7265, DOI 10.1073/pnas.1133870100
   Sasaoka T, 2006, PHARMACOL THERAPEUT, V112, P799, DOI 10.1016/j.pharmthera.2006.06.001
   SATO Y, 1984, HORM METAB RES, V16, P483, DOI 10.1055/s-2007-1014825
   Satoh H, 2004, J CLIN INVEST, V114, P224, DOI 10.1172/JCI200420785
   Sattar N, 2003, CIRCULATION, V108, P414, DOI 10.1161/01.CIR.0000080897.52664.94
   Sauter NS, 2008, ENDOCRINOLOGY, V149, P2208, DOI 10.1210/en.2007-1059
   SawkaVerhelle D, 1997, EUR J BIOCHEM, V250, P411, DOI 10.1111/j.1432-1033.1997.0411a.x
   SCHAFFER JE, 1994, CELL, V79, P427, DOI 10.1016/0092-8674(94)90252-6
   SCHECK SH, 1991, DIABETES RES CLIN EX, V16, P111
   Schmitz-Peiffer C, 2002, ANN NY ACAD SCI, V967, P146
   SEALS DR, 1984, JAMA-J AM MED ASSOC, V252, P645, DOI 10.1001/jama.252.5.645
   SEALS DR, 1984, J APPL PHYSIOL, V56, P1521, DOI 10.1152/jappl.1984.56.6.1521
   Sebastián D, 2007, AM J PHYSIOL-ENDOC M, V292, pE677, DOI 10.1152/ajpendo.00360.2006
   SEINO S, 1989, P NATL ACAD SCI USA, V86, P114, DOI 10.1073/pnas.86.1.114
   SEINO Y, 1995, CYTOKINE, V7, P575, DOI 10.1006/cyto.1995.0078
   Sell H, 2009, DIABETES, V58, P2731, DOI 10.2337/db09-0277
   Senn JJ, 2002, DIABETES, V51, P3391, DOI 10.2337/diabetes.51.12.3391
   Senn JJ, 2006, J BIOL CHEM, V281, P26865, DOI 10.1074/jbc.M513304200
   Sethi JK, 2000, FEBS LETT, V469, P77, DOI 10.1016/S0014-5793(00)01250-3
   Shaibi GQ, 2006, MED SCI SPORT EXER, V38, P1208, DOI 10.1249/01.mss.0000227304.88406.0f
   Shanely RA, 2013, SCAND J MED SCI SPOR, V23, P215, DOI 10.1111/j.1600-0838.2011.01373.x
   Shetty GK, 2004, DIABETES CARE, V27, P2450, DOI 10.2337/diacare.27.10.2450
   Shima Y, 2008, J PHYSIOL SCI, V58, P341, DOI 10.2170/physiolsci.RP004808
   Shisheva A, 2008, AM J PHYSIOL-ENDOC M, V295, pE536, DOI 10.1152/ajpendo.90353.2008
   Shojaee-Moradie F, 2007, DIABETOLOGIA, V50, P404, DOI 10.1007/s00125-006-0498-7
   Short KR, 2003, DIABETES, V52, P1888, DOI 10.2337/diabetes.52.8.1888
   Simoneau JA, 1999, FASEB J, V13, P2051, DOI 10.1096/fasebj.13.14.2051
   Simoneau JA, 1997, J APPL PHYSIOL, V83, P166, DOI 10.1152/jappl.1997.83.1.166
   Simons LA, 1996, MED J AUSTRALIA, V164, P208, DOI 10.5694/j.1326-5377.1996.tb94138.x
   Singh U, 2009, CLIN CHEM, V55, P361, DOI 10.1373/clinchem.2008.109207
   Sleigh A, 2011, J CLIN INVEST, V121, P2457, DOI 10.1172/JCI46405
   Smith SR, 2003, DIABETES, V52, P1611, DOI 10.2337/diabetes.52.7.1611
   SMUTOK MA, 1993, METABOLISM, V42, P177, DOI 10.1016/0026-0495(93)90032-J
   SMUTOK MA, 1994, INT J SPORTS MED, V15, P283, DOI 10.1055/s-2007-1021061
   Staib JL, 2009, EXP PHYSIOL, V94, P71, DOI 10.1113/expphysiol.2008.044685
   Standaert ML, 2004, J BIOL CHEM, V279, P24929, DOI 10.1074/jbc.M402440200
   Steensberg A, 2002, AM J PHYSIOL-ENDOC M, V283, pE1272, DOI 10.1152/ajpendo.00255.2002
   STEINBERG D, 1989, NEW ENGL J MED, V320, P915
   Steinberg GR, 2000, AM J PHYSIOL-ENDOC M, V279, pE1374, DOI 10.1152/ajpendo.2000.279.6.E1374
   Steinberg GR, 2004, AM J PHYSIOL-ENDOC M, V286, pE57, DOI 10.1152/ajpendo.00302.2003
   Steinberg GR, 2002, AM J PHYSIOL-ENDOC M, V283, pE187, DOI 10.1152/ajpendo.00542.2001
   Steinberg GR, 2006, J CLIN ENDOCR METAB, V91, P3592, DOI 10.1210/jc.2006-0638
   Stenbit AE, 1997, NAT MED, V3, P1096, DOI 10.1038/nm1097-1096
   Steppan CM, 2005, MOL CELL BIOL, V25, P1569, DOI 10.1128/MCB.25.4.1569-1575.2005
   Steppan CM, 2001, NATURE, V409, P307, DOI 10.1038/35053000
   Steppan CM, 2001, P NATL ACAD SCI USA, V98, P502, DOI 10.1073/pnas.98.2.502
   Stewart KJ, 2005, AM J PREV MED, V28, P9, DOI 10.1016/j.amepre.2004.09.006
   Stiles B, 2004, P NATL ACAD SCI USA, V101, P2082, DOI 10.1073/pnas.0308617100
   Stiles BL, 2006, MOL CELL BIOL, V26, P2772, DOI 10.1128/MCB.26.7.2772-2781.2006
   Stone S, 2006, HUM MOL GENET, V15, P2709, DOI 10.1093/hmg/ddl204
   STUART CA, 1988, METABOLISM, V37, P802, DOI 10.1016/0026-0495(88)90018-2
   Summers SA, 2006, PROG LIPID RES, V45, P42, DOI 10.1016/j.plipres.2005.11.002
   SUN XJ, 1991, NATURE, V352, P73, DOI 10.1038/352073a0
   SUN XJ, 1992, J BIOL CHEM, V267, P22662
   Suzuki T, 2008, AM HEART J, V156, P405, DOI 10.1016/j.ahj.2008.02.022
   Sweeney G, 1999, J BIOL CHEM, V274, P10071, DOI 10.1074/jbc.274.15.10071
   SZCZYPACZEWSKA M, 1989, INT J SPORTS MED, V10, P34, DOI 10.1055/s-2007-1024870
   Tabata I, 1999, J APPL PHYSIOL, V86, P909, DOI 10.1152/jappl.1999.86.3.909
   Takala TO, 1999, AM J PHYSIOL-ENDOC M, V276, pE706, DOI 10.1152/ajpendo.1999.276.4.E706
   TAMEMOTO H, 1994, NATURE, V372, P182, DOI 10.1038/372182a0
   Tamura Y, 2008, ARTERIOSCL THROM VAS, V28, P2195, DOI 10.1161/ATVBAHA.108.168633
   Tamura Y, 2010, J ATHEROSCLER THROMB, V17, P219, DOI 10.5551/jat.3368
   Tan BK, 2008, DIABETES, V57, P801, DOI 10.2337/db07-0990
   Tan BK, 2009, DIABETES, V58, P1971, DOI 10.2337/db08-1528
   Taniguchi CM, 2006, NAT REV MOL CELL BIO, V7, P85, DOI 10.1038/nrm1837
   Tanner CJ, 2002, AM J PHYSIOL-ENDOC M, V282, pE147, DOI 10.1152/ajpendo.2002.282.1.E147
   Tartaglia LA, 1995, CELL, V83, P1263, DOI 10.1016/0092-8674(95)90151-5
   Taylor EB, 2008, J BIOL CHEM, V283, P9787, DOI 10.1074/jbc.M708839200
   Taylor L, 2010, EUR J APPL PHYSIOL, V109, P849, DOI 10.1007/s00421-010-1430-x
   Thirone ACP, 2006, TRENDS ENDOCRIN MET, V17, P70, DOI 10.1016/j.tem.2006.01.005
   Thomas TR, 2010, J APPL PHYSIOL, V109, P3, DOI 10.1152/japplphysiol.01361.2009
   Thong FSL, 2007, DIABETES, V56, P414, DOI 10.2337/db06-0900
   Tjonna AE, 2008, CIRCULATION, V118, P346, DOI 10.1161/CIRCULATIONAHA.108.772822
   Todd MK, 2005, METABOLISM, V54, P1218, DOI 10.1016/j.metabol.2005.04.007
   TRACEY KJ, 1988, J EXP MED, V167, P1211, DOI 10.1084/jem.167.3.1211
   Treebak JT, 2010, AM J PHYSIOL-CELL PH, V298, pC377, DOI 10.1152/ajpcell.00297.2009
   TREMBLAY A, 1994, METABOLISM, V43, P814, DOI 10.1016/0026-0495(94)90259-3
   Trujillo ME, 2005, J INTERN MED, V257, P167, DOI 10.1111/j.1365-2796.2004.01426.x
   Trujillo ME, 2004, J CLIN ENDOCR METAB, V89, P5577, DOI 10.1210/jc.2004-0603
   Tsigos C, 1997, NEUROENDOCRINOLOGY, V66, P54, DOI 10.1159/000127219
   Tsimikas S, 2006, J AM COLL CARDIOL, V47, pC19, DOI 10.1016/j.jacc.2005.10.066
   Tsochatzis EA, 2009, SCAND J GASTROENTERO, V44, P6, DOI 10.1080/00365520802273058
   Tsukumo DML, 2007, DIABETES, V56, P1986, DOI 10.2337/db06-1595
   Turban S, 2011, FEBS LETT, V585, P269, DOI 10.1016/j.febslet.2010.12.022
   Turcotte LP, 1997, MOL CELL BIOCHEM, V166, P153, DOI 10.1023/A:1006846907394
   Turcotte LP, 2001, DIABETES, V50, P1389, DOI 10.2337/diabetes.50.6.1389
   Turcotte LP, 1999, J APPL PHYSIOL, V87, P285, DOI 10.1152/jappl.1999.87.1.285
   Ueki K, 2002, P NATL ACAD SCI USA, V99, P419, DOI 10.1073/pnas.012581799
   Uysal KT, 1997, NATURE, V389, P610, DOI 10.1038/39335
   Van Der Heijden GJ, 2010, MED SCI SPORT EXER, V42, P1973, DOI 10.1249/MSS.0b013e3181df16d9
   van der Heijden GJ, 2009, J CLIN ENDOCR METAB, V94, P4292, DOI 10.1210/jc.2009-1379
   Van Guilder GP, 2006, OBESITY, V14, P2127, DOI 10.1038/oby.2006.248
   van Harmelen V, 2000, OBES RES, V8, P337, DOI 10.1038/oby.2000.40
   Van Zwieten P A, 1997, Blood Press Suppl, V2, P67
   VANDERPOLL T, 1991, AM J PHYSIOL, V261, pE457, DOI 10.1152/ajpendo.1991.261.4.E457
   Vasseur F, 2002, HUM MOL GENET, V11, P2607, DOI 10.1093/hmg/11.21.2607
   Vgontzas AN, 2005, SLEEP MED REV, V9, P211, DOI 10.1016/j.smrv.2005.01.006
   Vistisen B, 2004, J LIPID RES, V45, P603, DOI 10.1194/jlr.M300424-JLR200
   Vukovich MD, 1996, J APPL PHYSIOL, V80, P240, DOI 10.1152/jappl.1996.80.1.240
   Wadley GD, 2001, J APPL PHYSIOL, V90, P436, DOI 10.1152/jappl.2001.90.2.436
   Waki H, 2003, J BIOL CHEM, V278, P40352, DOI 10.1074/jbc.M300365200
   Waki H, 2007, ANNU REV PATHOL-MECH, V2, P31, DOI 10.1146/annurev.pathol.2.010506.091859
   WALZ A, 1993, ADV EXP MED BIOL, V351, P129
   Wang JL, 2001, DIABETES, V50, P2786, DOI 10.2337/diabetes.50.12.2786
   Wang Y, 2009, DIABETES-METAB RES, V25, P13, DOI 10.1002/dmrr.928
   Wang Y, 2007, CLIN CHEM, V53, P34, DOI [10.1373/clinchem.2006.075614, 10.1007/s11461-007-0005-4]
   Wang Y, 2009, J ENDOCRINOL, V203, P65, DOI 10.1677/JOE-09-0026
   Wannamethee SG, 2006, J AM GERIATR SOC, V54, P1909, DOI 10.1111/j.1532-5415.2006.00974.x
   Wannamethee SG, 2005, ARCH INTERN MED, V165, P2644, DOI 10.1001/archinte.165.22.2644
   Wannamethee SG, 2000, ARCH INTERN MED, V160, P2108, DOI 10.1001/archinte.160.14.2108
   Warden S.J., 2008, British Journal of Sports Medicine, V42, P562, DOI DOI 10.1136/BJSM.2008
   Watson RT, 2007, CELL SIGNAL, V19, P2209, DOI 10.1016/j.cellsig.2007.06.003
   Watson RT, 2001, AM J PHYSIOL-CELL PH, V281, pC215, DOI 10.1152/ajpcell.2001.281.1.C215
   Weisberg SP, 2006, J CLIN INVEST, V116, P115, DOI 10.1172/JCI24335
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Wellen KE, 2003, J CLIN INVEST, V112, P1785, DOI 10.1172/JCI20514
   Whaley MH, 1999, MED SCI SPORT EXER, V31, P287, DOI 10.1097/00005768-199902000-00013
   WHITE MF, 1994, J BIOL CHEM, V269, P1
   White MF, 1998, MOL CELL BIOCHEM, V182, P3, DOI 10.1023/A:1006806722619
   Whiteman EL, 2002, TRENDS ENDOCRIN MET, V13, P444, DOI 10.1016/S1043-2760(02)00662-8
   Whyte LJ, 2010, METABOLISM, V59, P1421, DOI 10.1016/j.metabol.2010.01.002
   Wickham EP, 2009, METAB SYNDR RELAT D, V7, P179, DOI 10.1089/met.2008.0038
   Wijesekara N, 2005, MOL CELL BIOL, V25, P1135, DOI 10.1128/MCB.25.3.1135-1145.2005
   Wijndaele K, 2007, MED SCI SPORT EXER, V39, P233, DOI 10.1249/01.mss.0000247003.32589.a6
   Wildman RP, 2008, ARCH INTERN MED, V168, P1617, DOI 10.1001/archinte.168.15.1617
   Wilson FH, 2004, SCIENCE, V306, P1190, DOI 10.1126/science.1102521
   Wilson PWF, 2005, CIRCULATION, V112, P3066, DOI 10.1161/CIRCULATIONAHA.105.539528
   Winnick JJ, 2008, J CLIN ENDOCR METAB, V93, P771, DOI 10.1210/jc.2007-1524
   Withers DJ, 1998, NATURE, V391, P900, DOI 10.1038/36116
   Wojtaszewski JFP, 2005, J PHYSIOL-LONDON, V564, P563, DOI 10.1113/jphysiol.2005.082669
   Wolfrum C, 2001, P NATL ACAD SCI USA, V98, P2323, DOI 10.1073/pnas.051619898
   Wu J, 2011, CELL METAB, V13, P160, DOI 10.1016/j.cmet.2011.01.003
   Wu XD, 2001, J CLIN ENDOCR METAB, V86, P5973, DOI 10.1210/jc.86.12.5973
   Wu Y, 2005, BRIT J PHARMACOL, V146, P234, DOI 10.1038/sj.bjp.0706306
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Xu JW, 2007, MOL ENDOCRINOL, V21, P564, DOI 10.1210/me.2006-0354
   Yamada P, 2008, SPORTS MED, V38, P715, DOI 10.2165/00007256-200838090-00002
   Yamauchi T, 2008, INT J OBESITY, V32, pS13, DOI 10.1038/ijo.2008.233
   Yamauchi T, 2003, NATURE, V423, P762, DOI 10.1038/nature01705
   Yamauchi T, 2007, NAT MED, V13, P332, DOI 10.1038/nm1557
   Yan QW, 2007, DIABETES, V56, P2533, DOI 10.2337/db07-0007
   Yang Q, 2005, NATURE, V436, P356, DOI 10.1038/nature03711
   Yang RZ, 2006, AM J PHYSIOL-ENDOC M, V290, pE1253, DOI 10.1152/ajpendo.00572.2004
   Yfanti C, 2011, AM J PHYSIOL-ENDOC M, V300, pE761, DOI 10.1152/ajpendo.00207.2010
   YKIJARVINEN H, 1983, DIABETES, V32, P965, DOI 10.2337/diabetes.32.10.965
   Youngren JF, 2001, AM J PHYSIOL-ENDOC M, V280, pE528, DOI 10.1152/ajpendo.2001.280.3.E528
   Youngren JF, 2001, J APPL PHYSIOL, V91, P2240, DOI 10.1152/jappl.2001.91.5.2240
   Yu M, 2001, J APPL PHYSIOL, V90, P29, DOI 10.1152/jappl.2001.90.1.29
   Yuan MS, 2001, SCIENCE, V293, P1673, DOI 10.1126/science.1061620
   Yudkin JS, 1999, ARTERIOSCL THROM VAS, V19, P972, DOI 10.1161/01.ATV.19.4.972
   Yuen DYC, 2009, DIABETES, V58, P1086, DOI 10.2337/db08-0775
   Zabolotny JM, 2004, J BIOL CHEM, V279, P24844, DOI 10.1074/jbc.M310688200
   Zachwieja JJ, 1996, METABOLISM, V45, P254, DOI 10.1016/S0026-0495(96)90063-3
   ZAVARONI I, 1980, METABOLISM, V29, P970, DOI 10.1016/0026-0495(80)90041-4
   Zeigerer A, 2004, MOL BIOL CELL, V15, P4406, DOI 10.1091/mbc.E04-04-0333
   Zhang B, 1996, MOL ENDOCRINOL, V10, P1457, DOI 10.1210/me.10.11.1457
   Zhang JH, 2008, MOL ENDOCRINOL, V22, P1416, DOI 10.1210/me.2007-0420
   ZHANG YY, 1994, NATURE, V372, P425, DOI 10.1038/372425a0
   Zhou BJ, 2009, J PHYS CHEM A, V113, P5144, DOI 10.1021/jp810827w
   Zhou QL, 2004, BIOCHEM SOC T, V32, P817, DOI 10.1042/BST0320817
   Zinker BA, 2002, P NATL ACAD SCI USA, V99, P11357, DOI 10.1073/pnas.142298199
   Zisman A, 2000, NAT MED, V6, P924, DOI 10.1038/78693
   Zoppini G, 2006, NUTR METAB CARDIOVAS, V16, P543, DOI 10.1016/j.numecd.2005.09.004
   Zou CH, 2008, J NUTR BIOCHEM, V19, P277, DOI 10.1016/j.jnutbio.2007.06.006
NR 732
TC 561
Z9 635
U1 4
U2 128
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2040-4603
J9 COMPR PHYSIOL
JI Compr. Physiol.
PD JAN
PY 2013
VL 3
IS 1
BP 1
EP 58
DI 10.1002/cphy.c110062
PG 58
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 086AH
UT WOS:000314654900001
PM 23720280
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Perez-Cornago, A
   Ramírez, MJ
   Zulet, MA
   Martinez, JA
AF Perez-Cornago, Aurora
   Ramirez, Maria J.
   Zulet, M. Angeles
   Martinez, J. Alfredo
TI Effect of dietary restriction on peripheral monoamines and anxiety
   symptoms in obese subjects with metabolic syndrome
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Peripheral monoamines; Anxiety symptoms; Serotonin; Dopamine; Metabolic
   syndrome; Weight loss; Diet
ID WEIGHT-LOSS; BLOOD SEROTONIN; DOPAMINE; DEPRESSION; SYSTEM; ASSOCIATION;
   OVERWEIGHT; FAT; RECEPTORS; PROTEINS
AB Reduced circulating monoamines may have a role in the development of the metabolic syndrome (MetS), which is becoming a major health problem worldwide. Moreover, an association between anxiety disorder and MetS has been reported; however, it is not clear whether weight loss can diminish anxiety. This investigation is aimed to examine the effects of a weight loss intervention on peripheral monoamines levels and anxiety symptoms in subjects with metabolic syndrome (MetS). The study population encompassed subjects with MetS (age: 50 10 y.o. and BMI: 35.8 +/- 4.3 kg/m(2)) selected from the RESMENA study after they had completed the 6-month weight loss intervention (-30% energy). Anthropometric measurements, dietary records, anxiety symptoms, and blood monoamines levels were analysed before and after the intervention. Dopamine (DA) (+18.2%; 95% confidence interval (Cl): -51.2 to -0.5) and serotonin (5-HT) (+16.1%; 95% Cl: -26.3 to -2.2) blood levels were significantly increased after the intervention. Higher DA blood concentrations at the end of the study were inversely related with the carbohydrate intake during the study (B = -3.3; 95% Cl: -8.4 to 0.4) and basal DA levels predicted a greater decrease in body weight and anthropometric parameters. Subjects with higher 5-HT concentrations after the weight loss intervention also showed a lower energy intake during the intervention (B = 0.04; 95% Cl: 0.07 to 0.01). Additionally, anxiety symptoms decreased after the weight toss treatment (-28.3%; 95% Cl: 6.2-20.4), which was parallel to a greater decrease in body weight and anthropometric markers, being related to lower 5-HT basal levels. Dietary restriction in patients with MetS may help in reducing anxiety symptoms, and also in increasing 5-HTand DA blood levels. These results provide further insights regarding emotional and neurological factors behind weight loss. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Perez-Cornago, Aurora; Zulet, M. Angeles; Martinez, J. Alfredo] Univ Navarra, Dept Nutr Food Sci & Physiol, Ctr Nutr Res, Pamplona 31008, Spain.
   [Ramirez, Maria J.] Univ Navarra, Dept Pharmacol & Toxicol, Pamplona 31008, Spain.
   [Zulet, M. Angeles; Martinez, J. Alfredo] Carlos III Hlth Res Inst, CIBERobn, Madrid, Spain.
C3 University of Navarra; University of Navarra; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN
RP Martinez, JA (corresponding author), Univ Navarra, Dept Nutr Food Sci & Physiol, C Irunlarrea 1, Pamplona 31008, Spain.
EM jalfmtz@unav.es
RI Perez-Cornago, Aurora/C-1097-2016; Martinez Hernandez, J
   Alfredo/K-8709-2014; Zulet, M. Angeles/H-1317-2017; Ramirez, Maria
   Javier/H-4383-2017
OI Perez-Cornago, Aurora/0000-0002-5652-356X; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941; Zulet, M. Angeles/0000-0002-3926-0892;
   Ramirez, Maria Javier/0000-0002-3488-9579
FU Health Department of the Government of Navarra [48/2009]; Linea Especial
   about Nutrition, Obesity and Health (University of Navarra) [LE/97];
   Asociacion de Amigos Universidad de Navarra
FX This study was supported by the Health Department of the Government of
   Navarra (48/2009) and the Linea Especial about Nutrition, Obesity and
   Health (University of Navarra LE/97). The pre-doctoral research grant to
   Aurora Perez-Cornago from the Asociacion de Amigos Universidad de
   Navarra is gratefully acknowledged. The funding sources had no role in
   study design; in the collection, analysis and interpretation of data; in
   the writing of the report; and in the decision to submit the paper for
   publication.
CR AGHARANYA JC, 1985, NEUROCHEM INT, V7, P271, DOI 10.1016/0197-0186(85)90115-9
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Astrup A, 2008, LANCET, V372, P1906, DOI 10.1016/S0140-6736(08)61525-1
   Bas M, 2009, APPETITE, V52, P209, DOI 10.1016/j.appet.2008.09.017
   Berger M, 2009, ANNU REV MED, V60, P355, DOI 10.1146/annurev.med.60.042307.110802
   Carlin J, 2013, OBESITY, V21, P2513, DOI 10.1002/oby.20374
   Concato J, 2000, NEW ENGL J MED, V342, P1887, DOI 10.1056/NEJM200006223422507
   Daly ME, 1997, AM J CLIN NUTR, V66, P1072, DOI 10.1093/ajcn/66.5.1072
   de la Iglesia R., 2013, BR J NUTR, V23, P1
   Eliassi A, 2008, CLIN EXP PHARMACOL P, V35, P1065, DOI 10.1111/j.1440-1681.2008.04961.x
   ESLER M, 1990, PHYSIOL REV, V70, P963, DOI 10.1152/physrev.1990.70.4.963
   Eyres SL, 2014, NUTRITION, V30, P10, DOI 10.1016/j.nut.2013.05.028
   Fabricatore AN, 2011, INT J OBESITY, V35, P1363, DOI 10.1038/ijo.2011.2
   Fabricatore AN, 2009, BEHAV RES THER, V47, P685, DOI 10.1016/j.brat.2009.05.004
   Gariepy G, 2010, INT J OBESITY, V34, P407, DOI 10.1038/ijo.2009.252
   Kaczmarczyk MM, 2013, PSYCHONEUROENDOCRINO, V38, P1553, DOI 10.1016/j.psyneuen.2013.01.004
   Kimura K, 2010, AUTON NEUROSCI-BASIC, V156, P27, DOI 10.1016/j.autneu.2010.02.005
   Kyrou I, 2006, ANN NY ACAD SCI, V1083, P77, DOI 10.1196/annals.1367.008
   Lambert E, 2010, J HYPERTENS, V28, P543, DOI 10.1097/HJH.0b013e3283350ea4
   Lopez-Legarrea P, 2013, NUTR METAB, V10, DOI 10.1186/1743-7075-10-22
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Maron E, 2012, CURR PHARM DESIGN, V18, P5699, DOI 10.2174/138161212803530844
   McCarney R, 2007, BMC MED RES METHODOL, V7, DOI 10.1186/1471-2288-7-30
   Morton GJ, 2006, NATURE, V443, P289, DOI 10.1038/nature05026
   Nakatani Y, 2008, EUR J NEUROSCI, V27, P2466, DOI 10.1111/j.1460-9568.2008.06201.x
   Narita K, 2008, PSYCHONEUROENDOCRINO, V33, P305, DOI 10.1016/j.psyneuen.2007.11.013
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Perez-Cornago A., 2013, Clin. Nutr
   PERNET A, 1984, EUR J CLIN PHARMACOL, V26, P23, DOI 10.1007/BF00546703
   Reinholz J, 2008, NUTR METAB, V5, DOI 10.1186/1743-7075-5-35
   Rubí B, 2005, J BIOL CHEM, V280, P36824, DOI 10.1074/jbc.M505560200
   Rubí B, 2010, ENDOCRINOLOGY, V151, P5570, DOI 10.1210/en.2010-0745
   Sekiyama T, 2013, PSYCHIAT RES, V209, P560, DOI 10.1016/j.psychres.2013.03.009
   Somerset SM, 2011, CLIN NUTR, V30, P593, DOI 10.1016/j.clnu.2011.04.004
   Spielberger CD., 1971, INTERAM J PSYCHOL, V5, P3
   Stunes AK, 2011, DIABETES OBES METAB, V13, P551, DOI 10.1111/j.1463-1326.2011.01378.x
   Sumara G, 2012, CELL METAB, V16, P588, DOI 10.1016/j.cmet.2012.09.014
   Swencionis C, 2013, HEALTH PSYCHOL, V32, P439, DOI 10.1037/a0029186
   Tellez LA, 2013, SCIENCE, V341, P800, DOI 10.1126/science.1239275
   Wang GJ, 2001, LANCET, V357, P354, DOI 10.1016/S0140-6736(00)03643-6
   Watanabe H, 2011, CURR OPIN LIPIDOL, V22, P186, DOI 10.1097/MOL.0b013e3283462273
   Williams E, 2006, BIOL PSYCHOL, V71, P171, DOI 10.1016/j.biopsycho.2005.03.002
   Williams J, 2007, PLOS BIOL, V5, P2369, DOI 10.1371/journal.pbio.0050274
   Wurtman RJ, 2003, AM J CLIN NUTR, V77, P128, DOI 10.1093/ajcn/77.1.128
   Zhao J, 1999, INT J OBESITY, V23, P238, DOI 10.1038/sj.ijo.0800800
   Zulet MA, 2011, NUTR HOSP, V26, P16, DOI 10.3305/nh.2011.26.1.5050
   Zweifel LS, 2011, NAT NEUROSCI, V14, P620, DOI 10.1038/nn.2808
NR 47
TC 15
Z9 16
U1 0
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD SEP
PY 2014
VL 47
BP 98
EP 106
DI 10.1016/j.psyneuen.2014.05.003
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA AM2PY
UT WOS:000339694500011
PM 25001959
DA 2025-06-11
ER

PT J
AU Saloner, R
   Marquine, MJ
   Sundermann, EE
   Hong, SZ
   McCutchan, JA
   Ellis, RJ
   Heaton, RK
   Grant, I
   Cherner, M
AF Saloner, Rowan
   Marquine, Maria J.
   Sundermann, Erin E.
   Hong, Suzi
   McCutchan, John Allen
   Ellis, Ronald J.
   Heaton, Robert K.
   Grant, Igor
   Cherner, Mariana
TI COMT Val1 58Met Polymorphism, Cardiometabolic Risk, and Nadir CD4
   Synergistically Increase Risk of Neurocognitive Impairment in Men Living
   With HIV
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Article; Proceedings Paper
CT Annual Conference of the International-Neuropsychological-Society (INS)
CY FEB 21, 2019
CL New York, NY
SP Int Neuropsychol Soc
DE neuroAIDS; catechol-o-methyltransferase; HIV-associated neurocognitive
   disorders; metabolic syndrome; dopamine; immunosuppression
ID CATECHOL-O-METHYLTRANSFERASE; HUMAN-IMMUNODEFICIENCY-VIRUS; METABOLIC
   SYNDROME; CARDIOVASCULAR RISK; NEUROPSYCHOLOGICAL IMPAIRMENT; ABDOMINAL
   OBESITY; PHYSICAL-ACTIVITY; INFECTED PATIENTS; DEFICIT SCORES;
   BRAIN-FUNCTION
AB Objective: The Val allele of the Val158Met single-nucleotide polymorphism of the catechol-o-methyltransferase gene (COMT) results in faster metabolism and reduced bioavailability of dopamine (DA). Among persons living with HIV, Val carriers display neurocognitive deficits relative to Met carriers, presumably due to exacerbation of HIV-related depletion of DA. COMT may also impact neurocognition by modulating cardiometabolic function, which is often dysregulated among persons living with HIV. We examined the interaction of COMT, cardiometabolic risk, and nadir CD4 on neurocognitive impairment (NCI) among HIV+ men.
   Methods: Three hundred twenty-nine HIV+ men underwent COMT genotyping and neurocognitive and neuromedical assessments. Cohort-standardized z scores for body mass index, systolic blood pressure, glucose, triglycerides, and high-density lipoprotein cholesterol were averaged to derive a cardiometabolic risk score (CMRS). NCI was defined as demographically adjusted global deficit score of >= 0.5. Logistic regression modeled NCI as a function of COMT, CMRS, and their interaction, covarying for estimated premorbid function, race/ethnicity, and HIV-specific characteristics. Follow-up analysis included the 3-way interaction of COMT, CMRS, and nadir CD4.
   Results: Genotypes were 81 (24.6%) Met/Met, 147 (44.7%) Val/ Met, and 101 (30.7%) Val/Val. COMT interacted with CMRS (P = 0.02) such that higher CMRS increased risk of NCI among Val/Val [odds ratio (OR) = 2.13, P < 0.01], but not Val/Met (OR = 0.93, P > 0.05) or Met/Met (OR = 0.92, P > 0.05) carriers. Among Val/Val, nadir CD4 moderated the effect of CMRS (P < 0.01) such that higher CMRS increased likelihood of NCI only when nadir CD4 <180.
   Discussion: Results suggest a tripartite model by which genetically driven low DA reserve, cardiometabolic dysfunction, and historical immunosuppression synergistically enhance risk of NCI among HIV+ men, possibly due to neuroinflammation and oxidative stress.
C1 [Saloner, Rowan] San Diego State Univ Univ Calif San Diego, San Diego Joint Doctoral Program Clin Psychol, San Diego, CA USA.
   [Saloner, Rowan; Marquine, Maria J.; Sundermann, Erin E.; Hong, Suzi; Heaton, Robert K.; Grant, Igor; Cherner, Mariana] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.
   [McCutchan, John Allen] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA.
   [Ellis, Ronald J.] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA.
C3 California State University System; San Diego State University;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego
RP Saloner, R (corresponding author), Univ Calif San Diego, SDSU UC San Diego Joint Doctoral Program Clin Psy, HIV Neurobehav Res Program, 220 Dickinson St,Suite B,Mail Code 8231, San Diego, CA 92103 USA.
EM rsaloner@ucsd.edu
RI Ellis, Ronald/K-3543-2015; cherner, mariana/N-4810-2015
OI Saloner, Rowan/0000-0002-1351-6183
FU NIDA-funded Translational Methamphetamine AIDS Research Center (TMARC)
   [P50DA026306]; NIDA award [R01DA026334]; NIAAA [T32AA013525]; NIMH
   [K23MH105297]; National Institutes of Health [N01 MH22005,
   HHSN271201000036C, HHSN271201000030C]; Icahn School of Medicine at Mount
   Sinai; University of Texas; Imaging Component: Christine
   Fennema-Notestine; University of Washington; CNS HIV Anti-Retroviral
   Therapy Effects Research (CHARTER) [HHSN271201000036C,
   HHSN271201000030C, N01MH22005]
FX Supported by the NIDA-funded Translational Methamphetamine AIDS Research
   Center (TMARC) award P50DA026306 (PI: I.G.), NIDA award R01DA026334 (PI:
   M.C.), and the CNS HIV Anti-Retroviral Therapy Effects Research
   (CHARTER) study awards N01MH22005, HHSN271201000036C, and
   HHSN271201000030C. R.S. is supported by NIAAA award T32AA013525, and
   M.J.M. is supported by NIMH award K23MH105297. The CNS HIV
   Anti-Retroviral Therapy Effects Research was supported by awards N01
   MH22005, HHSN271201000036C, and HHSN271201000030C from the National
   Institutes of Health. The CNS HIV Anti-Retroviral Therapy Effects
   Research (CHARTER) group is affiliated with Johns Hopkins University;
   the Icahn School of Medicine at Mount Sinai; University of California,
   San Diego; University of Texas, Galveston; University of Washington,
   Seattle; Washington University, St. Louis; and is headquartered at the
   University of California, San Diego, and includes: Director: Igor Grant,
   MD; Co-Directors: Scott L. Letendre, MD, Ronald J. Ellis, MD, PhD, and
   Thomas D. Marcotte, PhD; Center Manager: Donald Franklin, Jr;
   Neuromedical Component: Ronald J. Ellis, MD, PhD (P. I.) and J. Allen
   McCutchan, MD; Laboratory and Virology Component: Scott Letendre, MD
   (Co-P. I.) and Davey M. Smith, MD (Co-P. I.); Neurobehavioral Component:
   R. K. H. (P. I.), J. Hampton Atkinson, MD, and Matthew Dawson; Imaging
   Component: Christine Fennema-Notestine, PhD (P. I.), Michael J Taylor,
   PhD, and Rebecca Theilmann, PhD; Data Management Component: Anthony C.
   Gamst, PhD (P. I.) and Clint Cushman; Statistics Component: Ian
   Abramson, PhD (P. I.) and Florin Vaida, PhD; Johns Hopkins University
   Site: Ned Sacktor (P. I.) and Vincent Rogalski; Icahn School of Medicine
   at Mount Sinai Site: Susan Morgello, MD (Co-P. I.) and David Simpson, MD
   (Co-P. I.), Letty Mintz, N. P.; University of California, San Diego
   Site: J. Allen McCutchan, MD (P. I.); University of Washington, Seattle
   Site: Ann Collier, MD (CoP. I.), Christina Marra, MD (Co-P. I.), and
   Sher Storey, PA-C.; University of Texas, Galveston Site: Benjamin
   Gelman, MD, PhD (P. I.), Eleanor Head, R. N., B. S. N.; and Washington
   University, St. Louis Site: David Clifford, MD (P. I.), Muhammad
   Al-Lozi, MD, and Mengesha Teshome, MD.
CR Anderson AM, 2015, J NEUROVIROL, V21, P559, DOI 10.1007/s13365-015-0359-6
   Annerbrink K, 2008, METABOLISM, V57, P708, DOI 10.1016/j.metabol.2008.01.012
   [Anonymous], 2017, Wide Range Achievement Test
   [Anonymous], 2004, Psychological Assessment Resources I. Revised Comprehensive Norms for an Expanded HalsteadReitan Battery: Demographically Adjusted Neuropsychological Norms for African American and Caucasian Adults Scoring Program
   Barbaro G, 2010, WORLD J CARDIOL, V2, P53, DOI 10.4330/wjc.v2.i3.53
   Beck A. T., 1996, BDI 2 BECK DEPRESSIO
   Bennette C, 2012, BMC MED RES METHODOL, V12, DOI 10.1186/1471-2288-12-21
   Blackstone K, 2012, CLIN NEUROPSYCHOL, V26, P894, DOI 10.1080/13854046.2012.694479
   Bousman C A, 2010, Interdiscip Perspect Infect Dis, V2010, P678648, DOI 10.1155/2010/678648
   Brunerova L, 2013, NEUROENDOCRINOLOGY, V97, P132, DOI 10.1159/000338405
   Cañizares S, 2014, SEMIN NEUROL, V34, P27, DOI 10.1055/s-0034-1372340
   Carey CL, 2004, J CLIN EXP NEUROPSYC, V26, P307, DOI 10.1080/13803390490510031
   Chen JS, 2004, AM J HUM GENET, V75, P807, DOI 10.1086/425589
   Cohrs S, 2004, NEUROSCI LETT, V360, P161, DOI 10.1016/j.neulet.2004.02.056
   Cysique LA, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061738
   d'Ettorre G, 2014, AIDS RES HUM RETROV, V30, P936, DOI [10.1089/aid.2014.0069, 10.1089/AID.2014.0069]
   Dawling S, 2001, CANCER RES, V61, P6716
   Dirajlal-Fargo S, 2016, ANTIVIR THER, V21, P237, DOI 10.3851/IMP2998
   Ellis RJ, 2011, AIDS, V25, P1747, DOI 10.1097/QAD.0b013e32834a40cd
   Esarey J, 2018, COMP POLIT STUD, V51, P1144, DOI 10.1177/0010414017730080
   Everall I, 2009, J NEUROVIROL, V15, P360, DOI 10.3109/13550280903131915
   Flierl MA, 2008, MOL MED, V14, P195, DOI 10.2119/2007-00105.Flierl
   Fornoni A, 2005, CURR HYPERTENS REP, V7, P88, DOI 10.1007/s11906-005-0080-6
   Ganguly P, 2015, NUTR J, V14, DOI 10.1186/1475-2891-14-6
   Gelman BB, 2006, J NEUROIMMUNE PHARM, V1, P410, DOI 10.1007/s11481-006-9030-6
   Gelman BB, 2012, J NEUROIMMUNE PHARM, V7, P686, DOI 10.1007/s11481-012-9345-4
   Goldman-Rakic PS, 2000, BRAIN RES REV, V31, P295, DOI 10.1016/S0165-0173(99)00045-4
   Gonzalez E, 2005, SCIENCE, V307, P1434, DOI 10.1126/science.1101160
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   HAMDI A, 1992, BRAIN RES, V589, P338, DOI 10.1016/0006-8993(92)91296-Q
   Heaton RK, 2010, NEUROLOGY, V75, P2087, DOI 10.1212/WNL.0b013e318200d727
   Heaton R.K., 2003, Clinical interpretation of the WAIS-III and WMS-III, P181, DOI DOI 10.1016/B978-012703570-3/50010-9
   Heaton RK, 2004, J INT NEUROPSYCH SOC, V10, P317, DOI 10.1017/S1355617704102130
   Heaton RK, 2011, J NEUROVIROL, V17, P3, DOI 10.1007/s13365-010-0006-1
   Hinkin CH, 2004, AIDS, V18, pS19, DOI 10.1097/00002030-200418001-00004
   Ho JE, 2012, AIDS, V26, P1115, DOI 10.1097/QAD.0b013e328352ce54
   Hodgkinson CA, 2008, ALCOHOL ALCOHOLISM, V43, P505, DOI 10.1093/alcalc/agn032
   Holmes ME, 2008, J PHYS ACT HEALTH, V5, P294, DOI 10.1123/jpah.5.2.294
   Hong SZ, 2015, BRAIN BEHAV IMMUN, V45, P1, DOI 10.1016/j.bbi.2014.10.008
   Jernigan TL, 2011, J NEUROVIROL, V17, P248, DOI 10.1007/s13365-011-0032-7
   Jia PL, 2017, AM J MED GENET B, V174, P413, DOI 10.1002/ajmg.b.32530
   Johnson PO., 1936, STAT RES MEMOIRS, V1, P57, DOI DOI 10.2307/302397
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   Kanasaki K, 2008, NATURE, V453, P1117, DOI 10.1038/nature06951
   Kanasaki M, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-08513-w
   Koutsilieri E, 2001, J NEURAL TRANSM, V108, P767, DOI 10.1007/s007020170051
   Kumar AM, 2011, J NEUROVIROL, V17, P26, DOI 10.1007/s13365-010-0003-4
   Kumar AM, 2009, J NEUROVIROL, V15, P257, DOI 10.1080/13550280902973952
   Laatikainen LM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061839
   Lee TT, 2015, J NEUROVIROL, V21, P535, DOI 10.1007/s13365-015-0354-y
   Levine AJ, 2014, J NEUROVIROL, V20, P243, DOI 10.1007/s13365-014-0241-y
   Levine AJ, 2014, JAIDS-J ACQ IMM DEF, V65, P481, DOI 10.1097/QAI.0000000000000069
   Levine AJ, 2012, J CLIN EXP NEUROPSYC, V34, P78, DOI 10.1080/13803395.2011.623118
   Lin TW, 2013, BRAIN SCI, V3, P39, DOI 10.3390/brainsci3010039
   Lindenberger U, 2008, FRONT NEUROSCI-SWITZ, V2, P234, DOI 10.3389/neuro.01.039.2008
   Longenecker CT, 2013, INT J CARDIOL, V168, P4039, DOI 10.1016/j.ijcard.2013.06.059
   MacDonald PL, 2000, EDUC PSYCHOL MEAS, V60, P735, DOI 10.1177/00131640021970871
   McCutchan JA, 2012, NEUROLOGY, V78, P485, DOI 10.1212/WNL.0b013e3182478d64
   Meiser J, 2013, CELL COMMUN SIGNAL, V11, DOI 10.1186/1478-811X-11-34
   Montayre J, 2020, CONTEMP NURSE, V56, P1, DOI 10.1080/10376178.2019.1640621
   Muñoz-Moreno JA, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0107625
   Norman MA, 2011, J CLIN EXP NEUROPSYC, V33, P793, DOI 10.1080/13803395.2011.559157
   Nou E, 2016, AIDS, V30, P1495, DOI 10.1097/QAD.0000000000001109
   Orellana RV, 2013, INT J CARDIOL, V168, P1610, DOI 10.1016/j.ijcard.2013.01.032
   PACE GW, 1995, FREE RADICAL BIO MED, V19, P523, DOI 10.1016/0891-5849(95)00047-2
   Paula AA, 2013, AIDS RES THER, V10, DOI 10.1186/1742-6405-10-32
   Persson N, 2016, FRONT AGING NEUROSCI, V8, DOI 10.3389/fnagi.2016.00034
   PLOMIN R, 1994, SCIENCE, V264, P1733, DOI 10.1126/science.8209254
   Preacher KJ, 2006, J EDUC BEHAV STAT, V31, P437, DOI 10.3102/10769986031004437
   Robertson KR, 2007, AIDS, V21, P1915, DOI 10.1097/QAD.0b013e32828e4e27
   Sacktor N, 2016, NEUROLOGY, V86, P334, DOI 10.1212/WNL.0000000000002277
   Saloner R, 2019, AIDS, V33, P1175, DOI 10.1097/QAD.0000000000002192
   Sattler FR, 2015, JAIDS-J ACQ IMM DEF, V68, P281, DOI 10.1097/QAI.0000000000000458
   Saylor D, 2016, NAT REV NEUROL, V12, P234, DOI [10.1038/nrneurol.2016.27, 10.1038/nrneurol.2016.53]
   Seay JS, 2013, PSYCHONEUROENDOCRINO, V38, P2647, DOI 10.1016/j.psyneuen.2013.06.022
   Sundermann EE, 2015, J NEUROVIROL, V21, P81, DOI 10.1007/s13365-014-0305-z
   Sverdlov AL, 2016, MEDIAT INFLAMM, V2016, DOI 10.1155/2016/8254590
   Tozzi V, 2005, J NEUROVIROL, V11, P265, DOI 10.1080/13550280590952790
   Tunbridge EM, 2008, AM J MED GENET B, V147B, P996, DOI 10.1002/ajmg.b.30700
   Tunbridge EM, 2011, CURR TOP BEHAV NEURO, V8, P119, DOI 10.1007/7854_2010_97
   Ueki N, 2017, HYPERTENSION, V69, P1156, DOI 10.1161/HYPERTENSIONAHA.117.09247
   Valcour VG, 2005, JAIDS-J ACQ IMM DEF, V38, P31, DOI 10.1097/00126334-200501010-00006
   Valcour Victor, 2011, Curr HIV/AIDS Rep, V8, P54, DOI 10.1007/s11904-010-0070-4
   Vance DE, 2014, J NEUROSCI NURS, V46, P292, DOI 10.1097/JNN.0000000000000074
   von Känel R, 2011, MED SCI SPORT EXER, V43, P181, DOI 10.1249/MSS.0b013e3181e6d478
   Wang GJ, 2004, BRAIN, V127, P2452, DOI 10.1093/brain/awh269
   Wang GJ, 2001, LANCET, V357, P354, DOI 10.1016/S0140-6736(00)03643-6
   Wayman WN, 2016, NEUROPSYCHOPHARMACOL, V41, P1965, DOI 10.1038/npp.2015.366
   West SG, 1996, J PERS, V64, P1, DOI 10.1111/j.1467-6494.1996.tb00813.x
   Widmer R Jay, 2014, Glob Cardiol Sci Pract, V2014, P291, DOI 10.5339/gcsp.2014.43
   World Health Organization, 1998, COMP DIAGN INT INT C
   Wright EJ, 2010, NEUROLOGY, V75, P864, DOI 10.1212/WNL.0b013e3181f11bd8
   Yan YQ, 2015, CELL, V160, P62, DOI 10.1016/j.cell.2014.11.047
   Yu B, 2019, JAIDS-J ACQ IMM DEF, V81, P95, DOI 10.1097/QAI.0000000000001964
   Zhang Y, 2014, PSYCHOPHARMACOLOGY, V231, P2211, DOI 10.1007/s00213-013-3410-4
NR 95
TC 9
Z9 9
U1 1
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1525-4135
EI 1077-9450
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD AUG 15
PY 2019
VL 81
IS 5
BP E148
EP E157
DI 10.1097/QAI.0000000000002083
PG 10
WC Immunology; Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S)
SC Immunology; Infectious Diseases
GA IQ5GA
UT WOS:000480778900003
PM 31107306
OA Green Submitted, Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Pimenta, AM
   Lahortiga-Ramos, F
   Sayon-Orea, C
   Martínez-González, MA
   Sánchez-Villegas, A
AF Pimenta, A. M.
   Lahortiga-Ramos, F.
   Sayon-Orea, C.
   Martinez-Gonzalez, M. A.
   Sanchez-Villegas, A.
TI Depression and metabolic syndrome in participants of the " Seguimiento
   Universidad de Navarra " (SUN) cohort study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Metabolic syndrome; Cohort studies; Abdominal obesity; Spain
ID PROSPECTIVE ASSOCIATIONS; SYNDROME COMPONENTS; FTO GENE; SYMPTOMS; RISK;
   INFLAMMATION; METAANALYSIS; VALIDATION; ANXIETY; HEALTH
AB Background: Depression is a major public health concern worldwide and its association with metabolic syndrome (MetS) remains unclear. Thus, we prospectively examined the association between depression and the risk of MetS, according to different diagnosis criteria.
   Methods: This study included 9,237 participants of a Spanish dynamic prospective cohort of adult university graduates [mean (SD) age: 36.7 year (10.7)], initially free of any specific criterion of MetS, who were followed up for a median of 8.3 years. The exposure variables were medical diagnosis of depression at baseline or in the first 2-year follow-up questionnaire. The outcome variable was the incidence of MetS, assessed according to each of three different criteria proposed by: International Diabetes Federation (IDF); National Cholesterol Education Program's Adult Treatment Panel III (NCEP-ATP III); IDF/NCEP-ATP III (updated harmonizing definition). Multivariable-adjusted Relative Risks (RR) of new-onset MetS and their 95% Confidence Intervals (95% CI) were estimated, using Poisson regression models.
   Results: The cumulative incidences of MetS were 475 cases (IDF definition), 288 cases (NCEP-ATP III definition) and 492 cases (update harmonized definition). No association was observed between baseline depression and incidence of MetS, but the presence of depression after 2-years of follow-up was significantly associated with a higher risk of new-onset MetS, according to NCEP-ATP III definition (multivariable-adjusted RR, 2.46; 95% CI, 1.06-5.67).
   Limitations: Diagnosis of depression and MetS were self-reported.
   Conclusions: In this large prospective cohort of Spanish middle-aged adult university graduates, a direct association between depression and the risk of MetS according to NCEP-ATP III definition was found.
C1 [Pimenta, A. M.] Univ Fed Minas Gerais, Dept Maternal Child Nursing & Publ Hlth, Belo Horizonte, MG, Brazil.
   [Pimenta, A. M.; Sanchez-Villegas, A.] Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci, Las Palmas Gran Canaria, Spain.
   [Lahortiga-Ramos, F.] Univ Clin Navarra, Dept Psychiat & Med Psychol, Pamplona, Spain.
   [Sayon-Orea, C.; Martinez-Gonzalez, M. A.] Univ Navarra, Dept Prevent Med & Publ Hlth, Pamplona, Spain.
   [Martinez-Gonzalez, M. A.; Sanchez-Villegas, A.] Inst Salud Carlos III, Ciber Fisiopatol Obesidad & Nutr CIBER OBN, Madrid, Spain.
   [Martinez-Gonzalez, M. A.] Harvard Univ, Dept Nutr, Harvard TH Chan Sch Publ Hlth, Boston, MA USA.
C3 Universidade Federal de Minas Gerais; Universidad de Las Palmas de Gran
   Canaria; University of Navarra; University of Navarra; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III;
   Harvard University; Harvard T.H. Chan School of Public Health
RP Pimenta, AM (corresponding author), Univ Fed Minas Gerais, Sch Nursing, Dept Maternal Child Nursing & Publ Hlth, Av Prof Alfredo Balena 190,4 Andar,Sala 422, BR-30130100 Belo Horizonte, MG, Brazil.
EM adrianomp@ufmg.br
RI Pimenta, Adriano/I-2380-2018; Lahortiga-Ramos, Francisca/H-9363-2017;
   Martinez-Gonzalez, Miguel/AAE-7669-2019; Sanchez-Villegas,
   Almudena/T-6733-2019; Sayon-Orea, Carmen/A-9828-2017
OI Martinez-Gonzalez, Miguel A./0000-0002-3917-9808; Sanchez Villegas,
   Almudena/0000-0001-7733-9238; Sayon-Orea, Carmen/0000-0002-4137-3263
FU Spanish Government-Instituto de Salud Carlos III [RD 06/0045,
   PI10/02658, PI10/02293, PI13/00615, PI14/01668, PI14/01798, PI14/01764,
   PI17/01795, G03/140]; European Regional Development Fund (FEDER) [RD
   06/0045, PI10/02658, PI10/02293, PI13/00615, PI14/01668, PI14/01798,
   PI14/01764, PI17/01795, G03/140]; Navarra Regional Government [27/2011,
   45/2011, 122/2014]; University of Navarra; Carolina Foundation
   (Spain)/Tordesillas Group (Brazil)
FX The SUN Project has received funding from the Spanish
   GovernmentInstituto de Salud Carlos III, and the European Regional
   Development Fund (FEDER) (RD 06/0045, CIBER-OBN, Grants PI10/02658,
   PI10/02293, PI13/00615, PI14/01668, PI14/01798, PI14/01764, PI17/01795,
   and G03/140), the Navarra Regional Government (27/2011, 45/2011,
   122/2014), and the University of Navarra. AMP received a postdoctoral
   fellowship from the Carolina Foundation (Spain)/Tordesillas Group
   (Brazil) for internship development at the Research Institute of
   Biomedical and Health Sciences, University of Las Palmas de Gran
   Canaria, Spain.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Amare AT, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/tp.2016.261
   [Anonymous], 2018, Monitoring Health for the SDGs, Sustainable Development Goals Internet
   [Anonymous], 2006, The IDF Consensus Worldwide Definition of the Metabolic Syndrome
   Bes-Rastrollo M, 2005, Rev. Esp. Obes, V3, P352
   Boschloo L, 2014, J AFFECT DISORDERS, V159, P73, DOI 10.1016/j.jad.2014.01.019
   Carlos S, 2018, NUTRIENTS, V10, DOI 10.3390/nu10040439
   de la Fuente-Arrillaga C, 2010, PUBLIC HEALTH NUTR, V13, P1364, DOI 10.1017/S1368980009993065
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Fernández-Montero A, 2011, GAC SANIT, V25, P303, DOI 10.1016/j.gaceta.2011.02.009
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Groenwold RHH, 2012, AM J EPIDEMIOL, V175, P210, DOI 10.1093/aje/kwr302
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Hiles SA, 2016, DEPRESS ANXIETY, V33, P754, DOI 10.1002/da.22512
   James SL, 2018, LANCET, V392, P1789, DOI [10.1016/s0140-6736(18)32335-3, 10.1016/S0140-6736(18)32335-3]
   Kim EY, 2015, J AFFECT DISORDERS, V188, P14, DOI 10.1016/j.jad.2015.08.024
   Klein S, 2007, DIABETES CARE, V30, P1647, DOI 10.2337/dc07-9921
   Krogh J, 2014, BRAIN BEHAV IMMUN, V35, P70, DOI 10.1016/j.bbi.2013.08.014
   Lasserre AM, 2017, MOL PSYCHIATR, V22, P1026, DOI 10.1038/mp.2016.178
   Lee Y, 2018, THER ADV PSYCHOPHARM, V8, P337, DOI 10.1177/2045125318791944
   Lopresti AL, 2013, J AFFECT DISORDERS, V148, P12, DOI 10.1016/j.jad.2013.01.014
   Martínez-González MA, 2005, PUBLIC HEALTH NUTR, V8, P920, DOI 10.1079/PHN2005745
   Milaneschi Y, 2014, MOL PSYCHIATR, V19, P960, DOI 10.1038/mp.2014.4
   Mora C, 2018, EXPERT REV MOL DIAGN, V18, P513, DOI 10.1080/14737159.2018.1470927
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Ortiz MS, 2018, REV MED CHILE, V146, P1278, DOI 10.4067/S0034-98872018001101278
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Rivera M, 2012, MOL PSYCHIATR, V17, P604, DOI 10.1038/mp.2011.45
   Rivera M, 2017, BRIT J PSYCHIAT, V211, P70, DOI 10.1192/bjp.bp.116.183475
   Robins J., 2019, IN PRESS
   Sanchez-Villegas A, 2008, BMC PSYCHIATRY, V8, DOI 10.1186/1471-244X-8-43
   Smith TW, 2017, ANN BEHAV MED, V51, P610, DOI 10.1007/s12160-017-9883-3
   Barrio-Lopez MT, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-867
   Trichopoulou A, 2003, NEW ENGL J MED, V348, P2599, DOI 10.1056/NEJMoa025039
   Vanhala M, 2009, ACTA PSYCHIAT SCAND, V119, P137, DOI 10.1111/j.1600-0447.2008.01283.x
   Willett W., 2013, Nutritional epidemiology, V3rd
   Womack VY, 2016, PSYCHOSOM MED, V78, P867, DOI 10.1097/PSY.0000000000000347
   Wong BCF, 2019, DEPRESS ANXIETY, V36, P330, DOI 10.1002/da.22861
NR 38
TC 8
Z9 8
U1 0
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD APR 1
PY 2021
VL 284
BP 183
EP 189
DI 10.1016/j.jad.2021.02.002
EA FEB 2021
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA QP1UI
UT WOS:000623621400021
PM 33607508
DA 2025-06-11
ER

PT J
AU Liu, LN
   Tan, RR
   Fang, ZH
   Li, L
   Chen, X
   Luo, YL
   Yang, D
AF Liu, Lini
   Tan, Rongrong
   Fang, Zhenghua
   Li, Li
   Chen, Xi
   Luo, Yinli
   Yang, Dong
TI Prevalence of non-alcoholic fatty liver disease in pediatric mental
   disorder inpatients: a tertiary mental health referral hospital study
SO REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
LA English
DT Article
DE Non-alcoholic fatty liver disease; Pediatric mental disorder;
   Schizophrenia; Bipolar disorder; Depressive disorder; Risk factor
ID RISK-FACTORS; PSYCHOTIC DISORDERS; METABOLIC SYNDROME; SCHIZOPHRENIA;
   CHILDREN; ADOLESCENTS; OBESITY; CHINA
AB Background and aim: studies have revealed a high preva-lence of non-alcoholic fatty liver disease (NAFLD) among adult patients with mental disorders, as well as its associated risk factors. However, little is known about this in the pedi-atric population. The aim of this study was to investigate the prevalence of NAFLD in pediatric inpatients with a mental disorder, and to explore the risk factors. Methods: in this retrospective study, 1,156 pediatric inpa-tients with a mental disorder and admitted to our hospital between January 2020 and December 2021 were included, including inpatients with schizophrenia, bipolar disorder, depressive disorder and other mental disorders. Relevant clinical data were obtained from the electronic medical records. The prevalence rate of NAFLD was calculated and compared with gender, mental disorders types, antipsychot-ics use and comorbidities. Multivariable logistic regression was used to examine risk factors associated with NAFLD. Results: the prevalence of NAFLD in pediatric inpatients with mental disorders was 7.35 % (85/1,156). Patients with NA-FLD were older than those without NAFLD (15.33 +/- 1.75 vs 14.21 +/- 1.95 years-old, p < 0.001). The NAFLD prevalence in participants with schizophrenia (12.11 %) was higher than in participants with bipolar disorder (8.45 %), depressive disor-der (7.06 %) and other mental disorders (2.97 %) (p = 0.002). The NAFLD prevalence was higher in participants who used antipsychotics (8.70 %) than in those who did not (5.45 %) (p = 0.038). Multivariate analysis revealed that older age, body weight (overweight/obese) and dyslipidemia were independent risk factors for NAFLD in pediatric inpatients with mental disorders. Conclusions: the NAFLD prevalence was higher in those pa-tients with schizophrenia and receiving antipsychotic medi-cation. Metabolic factors and longer evolution may explain these differences.
C1 [Liu, Lini; Tan, Rongrong; Fang, Zhenghua; Li, Li; Chen, Xi; Luo, Yinli; Yang, Dong] Brain Hosp Hunan Prov, Peoples Hosp Hunan Prov 2, Dept Psychiat, Changsha, Hunan, Peoples R China.
   [Yang, Dong] Brain Hosp Hunan Prov, Peoples Hosp Hunan Prov 2, Dept Psychiat, Changsha 410011, Hunan, Peoples R China.
RP Yang, D (corresponding author), Brain Hosp Hunan Prov, Peoples Hosp Hunan Prov 2, Dept Psychiat, Changsha 410011, Hunan, Peoples R China.
EM youngdong@163.com
RI Luo, Yinli/JRW-1420-2023; liu, lini/HLQ-4666-2023
FU Key Research Project of Human Province [2020SK2123, 2022SK2044];
   Clinical Medical Center of Depressive Disor-der of Hunan province
   [2021SK4022]; Research Project of Hunan Brain Hospital [2017B10]
FX Funding statement: the study was supported by the Key Research Project
   of Human Province (2020SK2123, 2022SK2044) , Clinical Medical Center of
   Depressive Disor-der of Hunan province (2021SK4022) , and Research
   Project of Hunan Brain Hospital (2017B10) .
CR Anderson EL, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0140908
   Brecelj J, 2021, MEDICINA-LITHUANIA, V57, DOI 10.3390/medicina57070719
   Crespo M, 2016, METABOLISM, V65, P1161, DOI 10.1016/j.metabol.2016.01.008
   Estes C, 2018, J HEPATOL, V69, P896, DOI 10.1016/j.jhep.2018.05.036
   Gallagher D., 2020, A Guide to Methods for Assessing Childhood Obesity
   Godin O, 2021, ACTA PSYCHIAT SCAND, V143, P82, DOI 10.1111/acps.13239
   Grossman DC, 2017, JAMA-J AM MED ASSOC, V317, P2417, DOI 10.1001/jama.2017.6803
   Gu YP, 2022, J AFFECT DISORDERS, V301, P8, DOI 10.1016/j.jad.2021.12.128
   Morlán-Coarasa MJ, 2016, PSYCHOPHARMACOLOGY, V233, P3947, DOI 10.1007/s00213-016-4422-7
   Karaivazoglou K, 2019, PSYCHOSOMATICS, V60, P10, DOI 10.1016/j.psym.2018.09.001
   Kerkar N, 2013, J PEDIATR GASTR NUTR, V56, P77, DOI 10.1097/MPG.0b013e31826f2b8c
   Kim D, 2019, ALIMENT PHARM THER, V50, P590, DOI 10.1111/apt.15395
   Kistler KD, 2010, ALIMENT PHARM THER, V31, P396, DOI 10.1111/j.1365-2036.2009.04181.x
   Koreki A, 2021, J CLIN PSYCHOPHARM, V41, P474, DOI 10.1097/JCP.0000000000001421
   Li J, 2021, AM J GASTROENTEROL, V116, P2068, DOI 10.14309/ajg.0000000000001386
   Li R, 2021, BIOMED PHARMACOTHER, V141, DOI 10.1016/j.biopha.2021.111803
   Li ZZ, 2014, J GASTROEN HEPATOL, V29, P42, DOI 10.1111/jgh.12428
   Ma QY, 2021, HEPATOL INT, V15, P127, DOI 10.1007/s12072-020-10132-z
   Mazzone L, 2013, HEPAT MON, V13, DOI 10.5812/hepatmon.7871
   Nobili V, 2016, GASTROENTEROLOGY, V150, P1798, DOI 10.1053/j.gastro.2016.03.009
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Querter I, 2022, CLIN GASTROENTEROL H, V20, P740, DOI 10.1016/j.cgh.2021.04.014
   Rostama B, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21249362
   Shapiro WL, 2021, PEDIATR OBES, V16, DOI 10.1111/ijpo.12849
   Thiagarajan S, 2022, INDIAN J GASTROENTER, V41, P63, DOI 10.1007/s12664-021-01198-0
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Wong VWS, 2018, J GASTROEN HEPATOL, V33, P70, DOI 10.1111/jgh.13857
   World Health Organization, 1996, INT STAT CLASS DIS H
   Yan J, 2017, NEUROPSYCH DIS TREAT, V13, P1493, DOI 10.2147/NDT.S137183
   Yan R, 2018, ANN HEPATOL, V17, P85, DOI 10.5604/01.3001.0010.7538
NR 30
TC 1
Z9 1
U1 0
U2 5
PU ARAN EDICIONES, S A
PI MADRID
PA CASTELLO, 128, 28006 MADRID, SPAIN
SN 1130-0108
EI 2340-4167
J9 REV ESP ENFERM DIG
JI Rev. Esp. Enferm. Dig.
PY 2023
VL 115
IS 2
BP 64
EP 69
DI 10.17235/reed.2022.8986/2022
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA D7LN0
UT WOS:000970505600004
PM 36281916
OA gold
DA 2025-06-11
ER

PT J
AU Seo, YG
   Lim, H
   Kim, Y
   Ju, YS
   Lee, HJ
   Jang, HB
   Park, SI
   Park, KH
AF Seo, Young-Gyun
   Lim, Hyunjung
   Kim, YoonMyung
   Ju, Young-Su
   Lee, Hye-Ja
   Jang, Han Byul
   Park, Sang Ick
   Park, Kyung Hee
TI The Effect of a Multidisciplinary Lifestyle Intervention on Obesity
   Status, Body Composition, Physical Fitness, and Cardiometabolic Risk
   Markers in Children and Adolescents with Obesity
SO NUTRIENTS
LA English
DT Article
DE intervention; lifestyle; nutrition; exercise; body composition;
   cardiometabolic risk; severe obesity; childhood obesity; adolescents;
   pediatrics
ID METABOLIC SYNDROME; CHILDHOOD OBESITY; DEPRESSION INVENTORY; OVERWEIGHT
   CHILDREN; ENERGY-EXPENDITURE; WEIGHT MANAGEMENT; AEROBIC FITNESS;
   UNITED-STATES; MASS INDEX; PREVALENCE
AB This study aimed to develop a multidisciplinary lifestyle intervention program targeted at children and adolescents with moderate to severe obesity, and assess the additional effects of exercise intervention when compared to usual care. Overall, the 103 enrolled participants were >= 85th percentile of age and sex-specific body mass index (BMI). Participants were divided into groups that received 16 weeks of either usual care or exercise intervention. The BMI z-score of the overall completers decreased by about 0.05 after the 16-week intervention (p = 0.02). After the intervention, only the exercise group had a significantly lower BMI z-score than the baseline score by about 0.1 (p = 0.03), but no significant group by time interaction effects were observed. At the 16-week follow-up, significant group by time interaction effects were observed in percentage body fat (%BF) (beta = -1.52, 95%CI = -2.58--0.45), lean body mass (LM) (beta = 1.20, 95%CI = 0.12-2.29), diastolic blood pressure (beta = -5.24, 95%CI = -9.66--0.83), high-sensitivity C-reactive protein (beta = -1.67, 95%CI = -2.77--1.01), and wall sit test score (beta = 50.74, 95%CI = 32.30-69.18). We developed a moderate-intensity intervention program that can be sustained in the real-world setting and is practically applicable to both moderate and severe obesity. After interventions, the exercise group had lower %BF and cardiometabolic risk markers, and higher LM and leg muscle strength compared to the usual care group.
C1 [Seo, Young-Gyun; Park, Kyung Hee] Hallym Univ, Dept Family Med, Sacred Heart Hosp, Anyang 14068, Gyeonggi Do, South Korea.
   [Lim, Hyunjung] Kyung Hee Univ, Dept Med Nutr, Yongin 17104, Gyeonggi Do, South Korea.
   [Kim, YoonMyung] Yonsei Univ Int Campus, Univ Coll, Incheon 21983, South Korea.
   [Ju, Young-Su] Hallym Univ, Dept Occupat & Environm Med, Sacred Heart Hosp, Anyang 14068, Gyeonggi Do, South Korea.
   [Lee, Hye-Ja; Jang, Han Byul; Park, Sang Ick] Korea Natl Inst Hlth, Ctr Biomed Sci, Cheongju 28159, Chungbuk, South Korea.
C3 Hallym University; Kyung Hee University; Hallym University; Korea
   Disease Control & Prevention Agency (KDCA); Korea National Institute of
   Health (KNIH); Korea CDC Center for Biomedical Science
RP Park, KH (corresponding author), Hallym Univ, Dept Family Med, Sacred Heart Hosp, Anyang 14068, Gyeonggi Do, South Korea.
EM yg035@daum.net; hjlim@khu.ac.kr; yoonkim@yonsei.ac.kr;
   zorro@hallym.ac.kr; hyejalee@korea.kr; greatstar@korea.kr;
   parksi@nih.go.kr; beloved920@gmail.com
RI Park, Kyung/AAU-7867-2020; Lim, Hyunjung/AAJ-4089-2020; Seo,
   Young-Gyun/AAV-3487-2020
OI Park, Kyung Hee/0000-0001-9806-0076; Seo,
   Young-Gyun/0000-0001-8294-1741; Ju, Young-Su/0000-0003-2829-9457
FU Korea Centers for Disease Control and Prevention [2015-ER6401-00]
FX This research was funded by the Korea Centers for Disease Control and
   Prevention, grant number 2015-ER6401-00.
CR Aring;berg ND, 2015, STROKE, V46, P1769, DOI 10.1161/STROKEAHA.115.009008
   Anderson YC, 2017, OBESITY, V25, P1965, DOI 10.1002/oby.21967
   [Anonymous], ANN SAMPL RES 2016 S
   Boudreau ADA, 2013, AM J PREV MED, V44, pS247, DOI 10.1016/j.amepre.2012.11.026
   Bull FC, 2009, J PHYS ACT HEALTH, V6, P790, DOI 10.1123/jpah.6.6.790
   Calcaterra V, 2008, CLIN ENDOCRINOL, V68, P868, DOI 10.1111/j.1365-2265.2007.03115.x
   CAREY MP, 1987, J CONSULT CLIN PSYCH, V55, P755, DOI 10.1037/0022-006X.55.5.755
   Cho S.C., 1990, Journal of the Korean Neuropsychiatric Association, V29, P943
   Croker H, 2012, INT J OBESITY, V36, P16, DOI 10.1038/ijo.2011.182
   Deforche B, 2003, EUR J PEDIATR, V162, P616, DOI 10.1007/s00431-003-1247-2
   Díez-Fernández A, 2018, SCAND J MED SCI SPOR, V28, P1801, DOI 10.1111/sms.13077
   Lisón JF, 2012, ACAD PEDIATR, V12, P319, DOI 10.1016/j.acap.2012.03.003
   Freedman DS, 2007, J PEDIATR-US, V150, P12, DOI 10.1016/j.jpeds.2006.08.042
   Hoedjes M, 2018, OBESITY FACTS, V11, P116, DOI 10.1159/000487328
   Johnston CA, 2011, J PEDIATR-US, V158, P624, DOI 10.1016/j.jpeds.2010.09.049
   Juonala M, 2011, NEW ENGL J MED, V365, P1876, DOI 10.1056/NEJMoa1010112
   Kalarchian MA, 2009, PEDIATRICS, V124, P1060, DOI 10.1542/peds.2008-3727
   Kelly AS, 2013, CIRCULATION, V128, P1689, DOI 10.1161/CIR.0b013e3182a5cfb3
   KNIGHT D, 1988, J CHILD PSYCHOL PSYC, V29, P853, DOI 10.1111/j.1469-7610.1988.tb00758.x
   Knöpfli BH, 2008, J ADOLESCENT HEALTH, V42, P119, DOI 10.1016/j.jadohealth.2007.08.015
   Kong AS, 2013, J OBES, V2013, DOI 10.1155/2013/575016
   Lazzer S, 2005, INT J OBESITY, V29, P37, DOI 10.1038/sj.ijo.0802845
   Levine MD, 2001, INT J EAT DISORDER, V30, P318, DOI 10.1002/eat.1091
   Lo JC, 2014, INT J PEDIATR ENDOCR, DOI 10.1186/1687-9856-2014-3
   문진수, 2008, Clinical and Experimental Pediatrics, V51, P1
   Nemet D, 2005, PEDIATRICS, V115, DOI 10.1542/peds.2004-2172
   Ng M, 2014, LANCET, V384, P746
   O'Connor EA, 2017, JAMA-J AM MED ASSOC, V317, P2427, DOI 10.1001/jama.2017.0332
   Ogden CL, 2016, JAMA-J AM MED ASSOC, V315, P2292, DOI 10.1001/jama.2016.6361
   Rank M, 2013, J PEDIATR-US, V163, P137, DOI 10.1016/j.jpeds.2013.01.020
   RAVUSSIN E, 1985, AM J CLIN NUTR, V41, P753, DOI 10.1093/ajcn/41.4.753
   Rijks JM, 2015, J CLIN ENDOCR METAB, V100, P3572, DOI 10.1210/jc.2015-1444
   Sachdev HPS, 2009, ARCH DIS CHILD, V94, P768, DOI 10.1136/adc.2008.140905
   Savoye M, 2007, JAMA-J AM MED ASSOC, V297, P2697, DOI 10.1001/jama.297.24.2697
   Shiroma EJ, 2017, MED SCI SPORT EXER, V49, P40, DOI 10.1249/MSS.0000000000001063
   Skinner AC, 2014, JAMA PEDIATR, V168, P561, DOI 10.1001/jamapediatrics.2014.21
   Styne DM, 2017, J CLIN ENDOCR METAB, V102, P709, DOI 10.1210/jc.2016-2573
   Tikkanen E, 2018, CIRCULATION, V137, P2583, DOI [10.1161/CIRCULATIONAHA.117.032432, 10.1161/circulationaha.117.032432]
   van der Baan-Slootweg O, 2014, JAMA PEDIATR, V168, P807, DOI 10.1001/jamapediatrics.2014.521
   Weiss R, 2004, NEW ENGL J MED, V350, P2362, DOI 10.1056/NEJMoa031049
   Whitaker RC, 1997, NEW ENGL J MED, V337, P869, DOI 10.1056/NEJM199709253371301
   Zolotarjova J, 2018, OBES REV, V19, P931, DOI 10.1111/obr.12680
   ZWIAUER KFM, 1992, INT J OBESITY, V16, P11
NR 43
TC 63
Z9 70
U1 2
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2019
VL 11
IS 1
AR 137
DI 10.3390/nu11010137
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA HJ8VI
UT WOS:000457477800104
PM 30634657
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Mellon, SH
   Gautam, A
   Hammamieh, R
   Jett, M
   Wolkowitz, OM
AF Mellon, Synthia H.
   Gautam, Aarti
   Hammamieh, Rasha
   Jett, Marti
   Wolkowitz, Owen M.
TI Metabolism, Metabolomics, and Inflammation in Posttraumatic Stress
   Disorder
SO BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Animal models; Inflammation; Metabolic syndrome; Metabolomics;
   Neuroinflammation; PTSD
ID COMBAT-RELATED PTSD; EARLY-LIFE ADVERSITY; C-REACTIVE PROTEIN;
   PSYCHIATRIC-DISORDERS; MOUSE MODEL; ANIMAL-MODELS; MITOCHONDRIAL
   DYSFUNCTION; PSYCHOSOCIAL STRESS; INSULIN-RESISTANCE; TRAUMA EXPOSURE
AB Posttraumatic stress disorder (PTSD) is defined by classic psychological manifestations, although among the characteristics are significantly increased rates of serious somatic comorbidities, such as cardiovascular disease, immune dysfunction, and metabolic syndrome. In this review, we assess the evidence for disturbances that may contribute to somatic pathology in inflammation, metabolic syndrome, and circulating metabolites (implicating mitochondrial dysfunction) in individuals with PTSD and in animal models simulating features of PTSD. The clinical and preclinical data highlight probable interrelated features of PTSD pathophysiology, including a proinflammatory milieu, metabolomic changes (implicating mitochondrial and other processes), and metabolic dysregulation. These data suggest that PTSD may be a systemic illness, or that it at least has systemic manifestations, and the behavioral manifestations are those most easily discerned. Whether somatic pathology precedes the development of PTSD (and thus may be a risk factor) or follows the development of PTSD (as a result of either shared pathophysiologies or lifestyle adaptations), comorbid PTSD and somatic illness is a potent combination placing affected individuals at increased physical as well as mental health risk. We conclude with directions for future research and novel treatment approaches based on these abnormalities.
C1 [Mellon, Synthia H.] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA USA.
   [Wolkowitz, Owen M.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA.
   [Gautam, Aarti; Hammamieh, Rasha; Jett, Marti] US Army Ctr Environm Hlth Res, US Army Med Res & Mat Command, Integrat Syst Biol, Frederick, MD USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   United States Department of Defense; United States Army
RP Jett, M (corresponding author), US Army Ctr Environm Hlth Res, 568 Doughten Dr, Frederick, MD 21702 USA.
EM marti.jett-tilton.civ@mail.mil
RI Wolkowitz, Owen/J-6649-2013
OI Hammamieh, Rasha/0000-0001-8643-6232; Gautam, Aarti/0000-0003-3132-5599
FU United States Army Medical Research and Materiel Command [09284002];
   United States Army Medical Research and Materiel Command Military
   Operational Medicine Research Program/Defense Health
   Agency/Congressional Special Interests [190040]; Department of Defense
   [W81XWH-11-2-0223, W81XWH-10-1-0021, VB4, T869, MM3]; United States Army
   Research Office
FX This work was supported by the United States Army Medical Research and
   Materiel Command (Grant No. 09284002 to MJ) and the United States Army
   Medical Research and Materiel Command Military Operational Medicine
   Research Program/Defense Health Agency/Congressional Special Interests
   (Grant No. 190040 to MJ). This work was funded by the Department of
   Defense (Grant Nos. W81XWH-11-2-0223 and W81XWH-10-1-0021 to SHM and OMW
   and Grant Nos. VB4, T869, and MM3 to MJ). We acknowledge the United
   States Army Research Office for their support. We also acknowledge Dr.
   Charles Marmar and his research group at New York University Medical
   Center and Dr. Rachel Yehuda and her research group at Mount Sinai
   School of Medicine and the James J. Peters Veterans Affairs Medical
   Center (Bronx, NY) for their tremendous efforts in sample collections
   and clinical assessments as well as all of the collaborators in the
   Systems Biology of PTSD research study. We thank Dr. Julia Scheerer for
   her editorial comments.
CR Amos T, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006239.pub2
   [Anonymous], INVISIBLE WOUNGS WAR
   [Anonymous], 2015, SCI REP
   [Anonymous], 2013, MEDIAT INFLAMM
   Baker DG, 2001, NEUROIMMUNOMODULAT, V9, P209, DOI 10.1159/000049028
   Banks WA, 1995, NEUROIMMUNOMODULAT, V2, P241, DOI 10.1159/000097202
   Bartoli F, 2013, METAB SYNDR RELAT D, V11, P301, DOI 10.1089/met.2013.0010
   Bastard JP, 2006, EUR CYTOKINE NETW, V17, P4
   Bersani FS, 2016, BRAIN BEHAV IMMUN, V56, P264, DOI 10.1016/j.bbi.2016.03.021
   Bersani FS, 2016, PROG NEURO-PSYCHOPH, V64, P10, DOI 10.1016/j.pnpbp.2015.06.012
   Birur Badari, 2017, Psychopharmacol Bull, V47, P8
   Blessing EM, 2017, PSYCHONEUROENDOCRINO, V82, P91, DOI 10.1016/j.psyneuen.2017.04.016
   Bonne O, 2011, J CLIN PSYCHIAT, V72, P1124, DOI 10.4088/JCP.09m05106blu
   Borghans B, 2015, WORLD J PSYCHIATR, V5, P387, DOI 10.5498/wjp.v5.i4.387
   Brenner LA, 2017, BRAIN BEHAV IMMUN, V65, P57, DOI 10.1016/j.bbi.2017.06.003
   Carter MJ, 2014, THER RECREAT J, V48, P275
   Cho JH, 2014, P NATL ACAD SCI USA, V111, P3188, DOI 10.1073/pnas.1400113111
   Chuang JC, 2010, J LIPID RES, V51, P1344, DOI 10.1194/jlr.M002196
   Cohen H, 2009, J NEUROENDOCRINOL, V21, P898, DOI 10.1111/j.1365-2826.2009.01913.x
   Cohen H, 2014, ILAR J, V55, P233, DOI 10.1093/ilar/ilu006
   Cohen M, 2011, INT J PSYCHIAT MED, V42, P117, DOI 10.2190/PM.42.2.b
   Czech B, 2013, INT J CLIN EXP PATHO, V6, P1585
   de Pablos RM, 2014, J NEUROINFLAMM, V11, DOI 10.1186/1742-2094-11-34
   Deslauriers J, 2018, BIOL PSYCHIAT, V83, P895, DOI 10.1016/j.biopsych.2017.11.019
   Deslauriers J, 2017, CURR OPIN BEHAV SCI, V14, P123, DOI 10.1016/j.cobeha.2017.01.005
   Deslauriers J, 2017, BEHAV BRAIN RES, V323, P117, DOI 10.1016/j.bbr.2017.01.048
   Dyall SC, 2015, FRONT AGING NEUROSCI, V7, DOI 10.3389/fnagi.2015.00052
   Ebenezer PJ, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0160923
   Edmondson D, 2017, LANCET PSYCHIAT, V4, P320, DOI 10.1016/S2215-0366(16)30377-7
   Elmquist Joel K, 2012, JAMA, V308, P1070
   Eraly SA, 2014, JAMA PSYCHIAT, V71, P423, DOI 10.1001/jamapsychiatry.2013.4374
   Farr OM, 2015, NUTR METAB CARDIOVAS, V25, P479, DOI 10.1016/j.numecd.2015.01.007
   Fielding BA, 2017, CURR OPIN CLIN NUTR, V20, P360, DOI 10.1097/MCO.0000000000000404
   Filiou MD, 2011, BIOL PSYCHIAT, V70, P1074, DOI 10.1016/j.biopsych.2011.06.009
   Fisman EZ, 2014, CARDIOVASC DIABETOL, V13, DOI 10.1186/1475-2840-13-103
   Frey WH, 2013, J NERV MENT DIS, V201, P638, DOI 10.1097/NMD.0b013e318298302e
   Friedman M.J., 2014, HDB PTSD SCI PRACTIC, V2nd
   Friedrich MJ, 2012, JAMA-J AM MED ASSOC, V308, P1077, DOI 10.1001/2012.jama.11024
   Friedrich N, 2012, J ENDOCRINOL, V215, P29, DOI 10.1530/JOE-12-0120
   Gamble-George JC, 2016, ELIFE, V5, DOI [10.7754/eLife.14137, 10.7554/eLife.14137]
   Garabadu D, 2015, J MOL NEUROSCI, V56, P299, DOI 10.1007/s12031-015-0532-7
   Gautam A, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0117092
   Gavrieli A, 2015, METABOLISM, V64, P1597, DOI 10.1016/j.metabol.2015.08.017
   Gill J, 2010, BIOL PSYCHIAT, V68, P999, DOI 10.1016/j.biopsych.2010.07.033
   Gocan AG, 2012, HORM MOL BIOL CLIN I, V10, P301, DOI 10.1515/hmbci-2011-0135
   Green DR, 2014, SCIENCE, V345, P1466, DOI 10.1126/science.1250256
   Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
   Hammamieh R, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/tp.2017.129
   Hammamieh R, 2012, BEHAV BRAIN RES, V235, P55, DOI 10.1016/j.bbr.2012.07.022
   Hemmings SMJ, 2017, PSYCHOSOM MED, V79, P936, DOI 10.1097/PSY.0000000000000512
   Heni M, 2015, NAT REV ENDOCRINOL, V11, P701, DOI 10.1038/nrendo.2015.173
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Jha SK, 2017, BBA-MOL BASIS DIS, V1863, P1132, DOI 10.1016/j.bbadis.2016.06.015
   Jia M, 2012, JOVE-J VIS EXP, DOI 10.3791/3361
   Johannessen KB, 2013, J CLIN PSYCHOL, V69, P655, DOI 10.1002/jclp.21962
   Johansen JP, 2011, CELL, V147, P509, DOI 10.1016/j.cell.2011.10.009
   Jones ME, 2015, NEUROPSYCHOPHARMACOL, V40, P1289, DOI 10.1038/npp.2014.317
   Kalyan-Masih P, 2016, ENEURO, V3, DOI 10.1523/ENEURO.0125-16.2016
   Kanabus M, 2014, BRIT J PHARMACOL, V171, P1798, DOI 10.1111/bph.12456
   Kang HK, 2003, AM J EPIDEMIOL, V157, P141, DOI 10.1093/aje/kwf187
   Kao Chi-Ya, 2016, Mol Neuropsychiatry, V2, P46, DOI 10.1159/000445377
   Kao CY, 2016, J PSYCHIATR RES, V76, P74, DOI 10.1016/j.jpsychires.2016.02.003
   Kao Chi-Ya, 2015, Mol Neuropsychiatry, V1, P60, DOI 10.1159/000381855
   Karabatsiakis Alexander, 2015, J Mol Psychiatry, V3, P2, DOI 10.1186/s40303-015-0007-3
   Kessler RC, 2005, ARCH GEN PSYCHIAT, V62, P593, DOI 10.1001/archpsyc.62.6.593
   Koenen KC, 2017, PSYCHOL MED, V47, P209, DOI [10.1017/s0033291716002294, 10.1017/S0033291716002294]
   Koves TR, 2008, CELL METAB, V7, P45, DOI 10.1016/j.cmet.2007.10.013
   Kulka R.A., 1990, TRAUMA VIETNAM WAR G
   Kusminski CM, 2012, TRENDS ENDOCRIN MET, V23, P435, DOI 10.1016/j.tem.2012.06.004
   Lee B, 2016, KOREAN J PHYSIOL PHA, V20, P357, DOI 10.4196/kjpp.2016.20.4.357
   Levine AB, 2014, CARDIOLOGY, V127, P1, DOI 10.1159/000354910
   Levkovitz Y, 2015, EUR NEUROPSYCHOPHARM, V25, P124, DOI 10.1016/j.euroneuro.2014.11.012
   Li XM, 2010, J CHEM NEUROANAT, V40, P248, DOI 10.1016/j.jchemneu.2010.07.001
   Lindqvist D, 2017, PSYCHIAT RES, V258, P330, DOI 10.1016/j.psychres.2017.08.052
   Lindqvist D, 2017, BRAIN BEHAV IMMUN, V59, P260, DOI 10.1016/j.bbi.2016.09.012
   Lindqvist D, 2015, NEUROSCI BIOBEHAV R, V55, P333, DOI 10.1016/j.neubiorev.2015.05.007
   Lindqvist D, 2014, BRAIN BEHAV IMMUN, V42, P81, DOI 10.1016/j.bbi.2014.06.003
   Liu B, 2003, J PHARMACOL EXP THER, V304, P1, DOI 10.1124/jpet.102.035048
   Liu DJ, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-211
   Lohr JB, 2015, AM J GERIAT PSYCHIAT, V23, P709, DOI 10.1016/j.jagp.2015.04.001
   Lopresti AL, 2013, PROG NEURO-PSYCHOPH, V45, P92, DOI 10.1016/j.pnpbp.2013.05.005
   Marsland AL, 2010, METABOLISM, V59, P1801, DOI 10.1016/j.metabol.2010.05.015
   McFarlane AC, 2017, CURR PSYCHIAT REP, V19, DOI 10.1007/s11920-017-0761-2
   Michopoulos V, 2016, EXP NEUROL, V284, P220, DOI 10.1016/j.expneurol.2016.05.038
   Michopoulos V, 2015, BIOL PSYCHIAT, V78, P344, DOI 10.1016/j.biopsych.2015.01.005
   Michopoulos V, 2015, AM J PSYCHIAT, V172, P353, DOI 10.1176/appi.ajp.2014.14020263
   Miller AH, 2017, NEUROPSYCHOPHARMACOL, V42, P334, DOI 10.1038/npp.2016.167
   Miller MW, 2018, BRAIN BEHAV IMMUN, V67, P194, DOI 10.1016/j.bbi.2017.08.022
   Montgomery MK, 2015, ENDOCR CONNECT, V4, DOI 10.1530/EC-14-0092
   Montier LLC, 2009, J GENET GENOMICS, V36, P125, DOI 10.1016/S1673-8527(08)60099-5
   Muhie S, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/tp.2017.91
   Muoio DM, 2008, NAT REV MOL CELL BIO, V9, P193, DOI 10.1038/nrm2327
   Naviaux RK, 2014, MITOCHONDRION, V16, P7, DOI 10.1016/j.mito.2013.08.006
   O'Donovan A, 2017, BRAIN BEHAV IMMUN, V60, P198, DOI 10.1016/j.bbi.2016.10.014
   O'Donovan A, 2015, BIOL PSYCHIAT, V77, P365, DOI 10.1016/j.biopsych.2014.06.015
   Olff M, 2017, CURR OPIN PSYCHOL, V14, P132, DOI 10.1016/j.copsyc.2017.01.001
   Pace TWW, 2011, BRAIN BEHAV IMMUN, V25, P6, DOI 10.1016/j.bbi.2010.10.003
   Pacella ML, 2013, J ANXIETY DISORD, V27, P33, DOI 10.1016/j.janxdis.2012.08.004
   Parikh S, 2009, CURR TREAT OPTION N, V11, P414, DOI 10.1007/s11940-009-0046-0
   Passos IC, 2015, LANCET PSYCHIAT, V2, P1002, DOI 10.1016/S2215-0366(15)00309-0
   Picard M, 2014, NAT REV ENDOCRINOL, V10, P303, DOI 10.1038/nrendo.2014.22
   Picca A, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18050933
   Raison CL, 2013, JAMA PSYCHIAT, V70, P31, DOI 10.1001/2013.jamapsychiatry.4
   Reagan LP, 2008, EUR J PHARMACOL, V585, P64, DOI 10.1016/j.ejphar.2008.02.050
   Rolland B, 2013, CURR DRUG TARGETS, V14, P724, DOI 10.2174/1389450111314070002
   Rosen RL, 2017, J PSYCHIATR RES, V89, P14, DOI 10.1016/j.jpsychires.2017.01.007
   Rosenbaum S, 2015, METABOLISM, V64, P926, DOI [10.1016/j.metabol.2015.04.009, 10.1016/j.metabol.2015.01.016]
   Sahin E, 2010, NATURE, V464, P520, DOI 10.1038/nature08982
   Sanghez V, 2013, PSYCHONEUROENDOCRINO, V38, P2933, DOI 10.1016/j.psyneuen.2013.07.022
   Santiago PN, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059236
   Schiavone S, 2016, PHARMACOL RES, V107, P195, DOI 10.1016/j.phrs.2016.03.019
   Schöner J, 2017, J CELL MOL MED, V21, P2248, DOI 10.1111/jcmm.13161
   Song C, 2004, MOL PSYCHIATR, V9, P630, DOI 10.1038/sj.mp.4001462
   Su YA, 2008, INT J BIOL SCI, V4, P223
   Swarbrick Michael M., 2008, Metabolic Syndrome and Related Disorders, V6, P87, DOI 10.1089/met.2007.0029
   Thakur GS, 2015, MOL BIOSYST, V11, P980, DOI 10.1039/c4mb00404c
   Tschopp J, 2011, EUR J IMMUNOL, V41, P1196, DOI 10.1002/eji.201141436
   Tsikunov SG, 2006, B EXP BIOL MED+, V141, P636, DOI 10.1007/s10517-006-0240-y
   Valero T, 2014, CURR PHARM DESIGN, V20, P5507, DOI 10.2174/138161282035140911142118
   Wan JL, 2016, ACTA HISTOCHEM, V118, P10, DOI 10.1016/j.acthis.2015.11.003
   Wang ZW, 2017, FRONT PSYCHIATRY, V8, DOI 10.3389/fpsyt.2017.00222
   Wang Z, 2016, HUM IMMUNOL, V77, P652, DOI 10.1016/j.humimm.2016.05.018
   Wang ZW, 2016, FRONT IMMUNOL, V7, DOI 10.3389/fimmu.2016.00219
   Wilson CB, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0089104
   Wolf EJ, 2016, PSYCHOL MED, V46, P2215, DOI 10.1017/S0033291716000817
   Wolf EJ, 2017, BRAIN BEHAV IMMUN, V65, P328, DOI 10.1016/j.bbi.2017.06.001
   Wolf EJ, 2016, PSYCHIAT ANN, V46, P527, DOI 10.3928/00485713-20160729-01
   Xiao B, 2011, CELL MOL NEUROBIOL, V31, P37, DOI 10.1007/s10571-010-9550-8
   Xing GQ, 2013, FRONT NEUROL, V4, DOI 10.3389/fneur.2013.00196
   Yehuda R, 2009, ANN NY ACAD SCI, V1179, P56, DOI 10.1111/j.1749-6632.2009.04979.x
   Zen AL, 2012, HEALTH PSYCHOL, V31, P194, DOI 10.1037/a0025989
   Zhang D, 2017, MOL PSYCHIATR, V22, P1044, DOI 10.1038/mp.2016.58
   Zhang L, 2006, MED HYPOTHESES, V66, P1205, DOI 10.1016/j.mehy.2005.11.041
   Zimmerman G, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.4
NR 134
TC 123
Z9 131
U1 0
U2 37
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 15
PY 2018
VL 83
IS 10
SI SI
BP 866
EP 875
DI 10.1016/j.biopsych.2018.02.007
PG 10
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA GD5QO
UT WOS:000430561800010
PM 29628193
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Shrestha, RM
   Mizoue, T
   Pham, TTP
   Fukunaga, A
   Hoang, DV
   Nguyen, CQ
   Phan, DC
   Hachiya, M
   Huynh, DV
   Le, HX
   Do, HT
   Inoue, Y
AF Shrestha, Rachana Manandhar
   Mizoue, Tetsuya
   Pham, Thuy Thi Phuong
   Fukunaga, Ami
   Hoang, Dong Van
   Nguyen, Chau Que
   Phan, Danh Cong
   Hachiya, Masahiko
   Huynh, Dong Van
   Le, Huy Xuan
   Do, Hung Thai
   Inoue, Yosuke
TI Association between parental absence during childhood and metabolic
   syndrome during adulthood: A cross-sectional study in rural Khanh Hoa,
   Vietnam
SO PLOS ONE
LA English
DT Article
ID ISCHEMIC-HEART-DISEASE; DEVELOPMENTAL ORIGINS; MAJOR DEPRESSION; RISK;
   EXPERIENCES; HEALTH; DEATH
AB BackgroundThis study aimed to determine the association between parental absence during childhood and metabolic syndrome (MetS) in adulthood among middle-aged adults in rural Khanh Hoa province, Vietnam. Given that broader literature on adverse childhood experiences (ACEs) suggests a strong positive association between ACEs and cardiometabolic risk or diseases, we hypothesized that parental absence during childhood, which is a major component of ACEs, is more likely to cause MetS in adulthood. MethodsData were obtained from the baseline survey of the Khanh Hoa Cardiovascular Study, in which 3000 residents aged between 40 to 60 years participated. MetS was assessed using the modified Adult Treatment Panel III (ATP III) criteria. It was considered parental absence if the participants had experienced parental absence due to death, divorce, or out-migration before three or between three to 15 years. We used multiple logistic regression analyses to examine the association between parental absence during childhood and metabolic syndrome during adulthood. ResultsThere was no significant association between parental absence and MetS; adjusted odds ratio [AOR] was 0.97 (95% confidence interval [CI] = 0.76-1.22) for those who experienced parental absence between three to 15 years and the corresponding figure for those who experienced it before three years was 0.93 (95% CI = 0.72-1.20). No significant associations were observed when these were examined for the causes of parental absence. ConclusionThis study did not support our hypothesis of an association between parental absence during childhood and metabolic syndrome during adulthood. Parental absence may not be a predictor of MetS among Vietnamese people in rural communities.
C1 [Shrestha, Rachana Manandhar; Mizoue, Tetsuya; Fukunaga, Ami; Hoang, Dong Van; Inoue, Yosuke] Natl Ctr Global Hlth & Med, Ctr Clin Sci, Dept Epidemiol & Prevent, Tokyo, Japan.
   [Pham, Thuy Thi Phuong; Nguyen, Chau Que; Phan, Danh Cong] Pasteur Inst Nha Trang, Dept Noncommunicable Dis Control & Nutr, Nha Trang, Khanh Hoa, Vietnam.
   [Hachiya, Masahiko] Natl Ctr Global Hlth & Med, Bur Int Hlth Cooperat, Tokyo, Japan.
   [Huynh, Dong Van] Khanh Hoa Ctr Dis Control, Nha Trang, Khanh Hoa, Vietnam.
   [Le, Huy Xuan; Do, Hung Thai] Pasteur Inst Nha Trang, Nha Trang, Khanh Hoa, Vietnam.
C3 Japan Institute for Health Security (JIHS); National Center for Global
   Health & Medicine - Japan; Japan Institute for Health Security (JIHS);
   National Center for Global Health & Medicine - Japan
RP Shrestha, RM (corresponding author), Natl Ctr Global Hlth & Med, Ctr Clin Sci, Dept Epidemiol & Prevent, Tokyo, Japan.
EM mrachana@hosp.ncgm.go.jp; yosuke.yoshi.yosky@gmail.com
RI Hachiya, Masahiko/ABF-8472-2021; Fukunaga, Ami/LFT-3303-2024
OI HUNG, DO THAI/0000-0003-2097-7364; Fukunaga, Ami/0000-0002-8705-0056;
   Manandhar Shrestha, Rachana/0000-0001-9289-8070; Que Chau,
   Nguyen/0000-0001-6276-8662
FU National Center for Global Health and Medicine [19A06]; Pfizer Health
   Research Foundation; Japan Society for the Promotion of Science
   [JP19K20536, JP21J01171, 21K17301]
FX The KhanhHoa Cardiovascular Studyprojectwas fundedby the
   NationalCenterforGlobalHealthand
   Medicine(19A06),PfizerHealthResearchFoundationand the JapanSocietyfor
   thePromotionof
   Science(KAKENHIJP19K20536;JP21J01171;21K17301).Thesefundershad norole in
   the studydesign,executionof the
   study,statisticalanalyses,interpretationof the data ordecisionto
   submitthe manuscriptfor publication
CR Agid O, 1999, MOL PSYCHIATR, V4, P163, DOI 10.1038/sj.mp.4000473
   Alastalo H, 2012, PSYCHOSOM MED, V74, P583, DOI 10.1097/PSY.0b013e31825b3d76
   Alciati A, 2013, STRESS HEALTH, V29, P5, DOI 10.1002/smi.1435
   Brown DW, 2009, AM J PREV MED, V37, P389, DOI 10.1016/j.amepre.2009.06.021
   Bull FC, 2009, J PHYS ACT HEALTH, V6, P790, DOI 10.1123/jpah.6.6.790
   Nguyen CQ, 2022, PUBLIC HEALTH NUTR, DOI 10.1017/S1368980022001422
   Chen H, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2020-043657
   Chen H, 2020, PSYCHOSOM MED, V82, P810, DOI 10.1097/PSY.0000000000000861
   Danese A, 2009, ARCH PEDIAT ADOL MED, V163, P1135, DOI 10.1001/archpediatrics.2009.214
   Dong MX, 2004, CIRCULATION, V110, P1761, DOI 10.1161/01.CIR.0000143074.54995.7F
   Pham DT, 2019, ARCH PHARM PRACT, V10, P43
   Ellis J, 2013, J ROY SOC MED, V106, P57, DOI 10.1177/0141076812472623
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Inoue Y, 2022, J AFFECT DISORDERS, V311, P479, DOI 10.1016/j.jad.2022.05.102
   Jakubowski KP, 2018, HEALTH PSYCHOL, V37, P701, DOI 10.1037/hea0000637
   Kendler KS, 2002, PSYCHOL MED, V32, P1187, DOI 10.1017/S0033291702006219
   Korkeila J, 2010, HEART, V96, P298, DOI 10.1136/hrt.2009.188250
   Luecken L.J., 2008, HDB BEREAVEMENT RES, P397, DOI DOI 10.1037/14498-019
   Luecken LJ, 1998, PSYCHOSOM MED, V60, P765, DOI 10.1097/00006842-199811000-00021
   Mandy M, 2018, INT HEALTH, V10, P66, DOI 10.1093/inthealth/ihy006
   Nguyen VD., 2019, J GLOB HLTH SCI, V1, pe7, DOI [10.35500/jghs.2019.1.e7, DOI 10.35500/JGHS.2019.1.E7]
   Phillips SP, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0120762
   Rubin DB., 1987, Multiple Imputation for Nonresponse in Surveys, P258
   Schooling CM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019675
   Simbi CMC, 2020, J AFFECT DISORDERS, V260, P272, DOI 10.1016/j.jad.2019.07.087
   Binh TQ, 2014, BMC ENDOCR DISORD, V14, DOI 10.1186/1472-6823-14-77
   Uauy R, 2011, AM J CLIN NUTR, V94, p1759S, DOI 10.3945/ajcn.110.000562
   Wadhwa PD, 2009, SEMIN REPROD MED, V27, P358, DOI 10.1055/s-0029-1237424
NR 28
TC 2
Z9 2
U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 9
PY 2023
VL 18
IS 3
AR e0282731
DI 10.1371/journal.pone.0282731
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 9W4SF
UT WOS:000949067800093
PM 36893153
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Molina-Leyva, A
   Molina-Leyva, I
   Almodovar-Real, A
   Ruiz-Carrascosa, JC
   Naranjo-Sintes, R
   Jimenez-Moleon, JJ
AF Molina-Leyva, Alejandro
   Molina-Leyva, Ignacio
   Almodovar-Real, Ana
   Carlos Ruiz-Carrascosa, Jose
   Naranjo-Sintes, Ramon
   Juan Jimenez-Moleon, Jose
TI Prevalence and Associated Factors of Erectile Dysfunction in Patients
   With Moderate to Severe Psoriasis and Healthy Population: A Comparative
   Study Considering Physical and Psychological Factors
SO ARCHIVES OF SEXUAL BEHAVIOR
LA English
DT Article
DE Anxiety; Organic/medical factors; Psychological factors; Depression;
   Erectile dysfunction; Psoriasis
ID SEXUAL FUNCTIONING QUESTIONNAIRE; INFLAMMATORY-BOWEL-DISEASE;
   QUALITY-OF-LIFE; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; DEPRESSIVE
   SYMPTOMS; ANXIETY; RISK; MEN; METAANALYSIS
AB Recent studies have shown that psoriasis is associated with an increased prevalence of erectile dysfunction. To our knowledge, no comparative study has considered simultaneously the role of organic factors and psychological factors in this process. We performed a prospective case series study matched by age to explore the prevalence of erectile dysfunction in psoriasis patients compared to a healthy population and to investigate the role of anxiety, depression, and cardiovascular risk factors in the relationship between psoriasis and erectile dysfunction. The healthy group was matched by frequency to cases by age. Seventy-nine patients with moderate to severe psoriasis and 79 healthy controls participated in the study. Participants completed the Massachusetts General Hospital Sexual Functioning Questionnaire and the Hospital Anxiety and Depression Scale. Psoriasis patients had an increased prevalence of erectile dysfunction in comparison to controls, 34.2 vs. 17.7 % (p < .05). Multivariate analysis showed a significant association between erectile dysfunction and age, smoking and anxiety/depression, but not with psoriasis per se. In conclusion, the higher prevalence of smoking and anxiety/depression among patients with moderate to severe psoriasis probably explains the higher prevalence of erectile dysfunction in this population.
C1 [Molina-Leyva, Alejandro] Complejo Hosp Torrecardenas, Dept Dermatol, Almeria, Spain.
   [Molina-Leyva, Ignacio; Juan Jimenez-Moleon, Jose] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain.
   [Almodovar-Real, Ana] Hosp Santa Ana, Dept Dermatol, Granada, Spain.
   [Molina-Leyva, Alejandro; Carlos Ruiz-Carrascosa, Jose; Naranjo-Sintes, Ramon] Complejo Hosp Univ Granada, Dept Dermatol, Ave Doctor Oloriz 16, Granada 18012, Spain.
   [Juan Jimenez-Moleon, Jose] CIBER Epidemiol & Salud Publ, Madrid, Spain.
C3 Hospital Torrecardenas; University of Granada; University of Granada;
   CIBER - Centro de Investigacion Biomedica en Red; CIBERESP
RP Molina-Leyva, A (corresponding author), Complejo Hosp Torrecardenas, Dept Dermatol, Almeria, Spain.; Molina-Leyva, A (corresponding author), Complejo Hosp Univ Granada, Dept Dermatol, Ave Doctor Oloriz 16, Granada 18012, Spain.
EM alejandromolinaleyva@gmail.com
RI ; Molina-Leyva, Alejandro/M-1213-2014; Jimenez-Moleon, Jose
   J./O-2519-2016
OI Molina Leyva, Ignacio/0000-0003-4424-398X; Molina-Leyva,
   Alejandro/0000-0001-6882-2113; Almodovar Real, Ana
   Maria/0000-0003-4054-7468; Jimenez-Moleon, Jose J./0000-0001-7917-6145
CR Ahdout J, 2012, CLIN EXP DERMATOL, V37, P477, DOI 10.1111/j.1365-2230.2012.04360.x
   AlShahwan MA, 2015, J CUTAN MED SURG, V19, P297, DOI 10.2310/7750.2014.14110
   Armstrong AW, 2013, J AM ACAD DERMATOL, V68, P654, DOI 10.1016/j.jaad.2012.08.015
   Cabete J, 2014, EUR J DERMATOL, V24, P482, DOI 10.1684/ejd.2014.2388
   Sierra JC, 2012, ATEN PRIM, V44, P516, DOI 10.1016/j.aprim.2012.02.004
   Chen YJ, 2013, J SEX MED, V10, P1212, DOI 10.1111/j.1743-6109.2012.02767.x
   Chew KK, 2004, INT J IMPOT RES, V16, P201, DOI 10.1038/sj.ijir.3901181
   Chung SD, 2012, J SEX MED, V9, P130, DOI 10.1111/j.1743-6109.2011.02510.x
   Corona G, 2009, INT J ANDROL, V32, P587, DOI 10.1111/j.1365-2605.2008.00951.x
   Corona G, 2012, J SEX MED, V9, P2017, DOI 10.1111/j.1743-6109.2012.02762.x
   Derogatis LR, 2008, ADV PSYCHOSOM MED, V29, P7, DOI 10.1159/000126621
   Ermertcan AT, 2006, J DERMATOL, V33, P772, DOI 10.1111/j.1346-8138.2006.00179.x
   FELDMAN HA, 1994, J UROLOGY, V151, P54, DOI 10.1016/S0022-5347(17)34871-1
   Ghazi LJ, 2015, INFLAMM BOWEL DIS, V21, P939, DOI 10.1097/MIB.0000000000000260
   Goulding JMR, 2011, BRIT J DERMATOL, V164, P103, DOI 10.1111/j.1365-2133.2010.10077.x
   Hatzimouratidis K., 2013, GUIDELINES MALE SEXU
   Hatzimouratidis K, 2010, EUR UROL, V57, P804, DOI 10.1016/j.eururo.2010.02.020
   Hayes J, 2010, DERMATOL THER, V23, P174, DOI 10.1111/j.1529-8019.2010.01312.x
   Holt RIG, 2013, J AFFECT DISORDERS, V150, P84, DOI 10.1016/j.jad.2013.02.026
   Kubin M, 2003, INT J IMPOT RES, V15, P63, DOI 10.1038/sj.ijir.3900949
   Kurd SK, 2010, ARCH DERMATOL, V146, P891, DOI 10.1001/archdermatol.2010.186
   Labbate LA, 2001, PSYCHOTHER PSYCHOSOM, V70, P221, DOI 10.1159/000056257
   Litwin MS, 1998, J GEN INTERN MED, V13, P159, DOI 10.1046/j.1525-1497.1998.00050.x
   Martin-Morales A, 2001, J UROLOGY, V166, P569, DOI 10.1016/S0022-5347(05)65986-1
   McDermott E, 2015, INFLAMM BOWEL DIS, V21, P353, DOI 10.1097/MIB.0000000000000287
   McDonough E, 2014, J RHEUMATOL, V41, P887, DOI 10.3899/jrheum.130797
   McMahon CG, 2014, INTERN MED J, V44, P18, DOI 10.1111/imj.12325
   MIETTINEN OS, 1981, AM J EPIDEMIOL, V114, P593, DOI 10.1093/oxfordjournals.aje.a113225
   MORSE WI, 1982, CAN MED ASSOC J, V127, P599
   Naccarato AM, 2014, ACTAS UROL ESP, V38, P385, DOI 10.1016/j.acuro.2013.10.012
   Navinés R, 2012, J AFFECT DISORDERS, V138, P343, DOI 10.1016/j.jad.2012.01.018
   Nehra A, 2012, MAYO CLIN PROC, V87, P766, DOI 10.1016/j.mayocp.2012.06.015
   Nelson CJ, 2011, J SEX MED, V8, P560, DOI 10.1111/j.1743-6109.2010.02127.x
   Nunes KP, 2012, CURR OPIN NEPHROL HY, V21, P163, DOI 10.1097/MNH.0b013e32835021bd
   Puig L, 2009, ACTAS DERMO-SIFILOGR, V100, P277, DOI 10.1016/S0001-7310(09)70821-X
   Quintana JM, 2003, ACTA PSYCHIAT SCAND, V107, P216, DOI 10.1034/j.1600-0447.2003.00062.x
   Rapp SR, 1999, J AM ACAD DERMATOL, V41, P401, DOI 10.1016/S0190-9622(99)70112-X
   Raychaudhuri SP, 2001, J EUR ACAD DERMATOL, V15, P16, DOI 10.1046/j.1468-3083.2001.00192.x
   Rieder E, 2012, INT J DERMATOL, V51, P12, DOI 10.1111/j.1365-4632.2011.05071.x
   Robinson A, 2012, J AM ACAD DERMATOL, V66, P369, DOI 10.1016/j.jaad.2011.01.022
   Rosen RC, 2004, INT J IMPOT RES, V16, P334, DOI 10.1038/sj.ijir.3901197
   Russo Paul A J, 2004, Australas J Dermatol, V45, P155, DOI 10.1111/j.1440-0960.2004.00078.x
   Schmidt HM, 2014, J SEX MED, V11, P1376, DOI 10.1111/jsm.12520
   Tasliyurt T, 2014, EUR REV MED PHARMACO, V18, P581
   Tostes RC, 2008, J SEX MED, V5, P1284, DOI 10.1111/j.1743-6109.2008.00804.x
   Tristano AG, 2014, WORLD J ORTHOP, V5, P107, DOI 10.5312/wjo.v5.i2.107
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 47
TC 20
Z9 22
U1 0
U2 7
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0004-0002
EI 1573-2800
J9 ARCH SEX BEHAV
JI Arch. Sex. Behav.
PD NOV
PY 2016
VL 45
IS 8
BP 2047
EP 2055
DI 10.1007/s10508-016-0757-8
PG 9
WC Psychology, Clinical; Social Sciences, Interdisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology; Social Sciences - Other Topics
GA DY5WM
UT WOS:000385175100016
PM 27270734
DA 2025-06-11
ER

PT J
AU Schmidt, MV
   Czisch, M
   Sterlemann, V
   Reinel, C
   Sämann, P
   Müller, MB
AF Schmidt, M. V.
   Czisch, M.
   Sterlemann, V.
   Reinel, C.
   Saemann, P.
   Mueller, M. B.
TI Chronic social stress during adolescence in mice alters fat distribution
   in late life: Prevention by antidepressant treatment
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Article
DE Chronic stress; metabolic syndrome; obesity; paroxetine; subcutaneous
   fat; visceral fat
ID METABOLIC SYNDROME; MAJOR DEPRESSION; OBESITY; NEUROENDOCRINE; MEN
AB Obesity and visceral fat accumulation are key features of the metabolic syndrome that represents one of the main health problems in western societies due to its neurovascular and cardiovascular complications. Epidemiological studies have identified chronic stress exposure as an important risk factor for the development of obesity and metabolic syndrome, but also psychiatric diseases, especially affective disorders. However, it is still unclear if chronic stress has merely transient or potentially lasting effects on body composition. Here, we investigated the effects of chronic social stress during the adolescent period on body fat composition in mice one year after the cessation of the stressor. We found that stress exposure during the adolescent period decreases subcutaneous fat content, without change in visceral fat, and consequently increases the visceral fat/subcutaneous fat ratio in adulthood. Further, we demonstrated that treatment with a selective serotonin reuptake inhibitor (paroxetine) during stress exposure prevented later effects on body fat distribution. These results from a recently validated chronic stress paradigm in mice provide evidence that stressful experiences during adolescence can alter body fat distribution in adulthood, thereby possibly contributing to an increased risk for metabolic diseases. Antidepressant treatment disrupted this effect underlining the link between the stress hormone system, metabolic homeostasis and affective disorders.
C1 [Schmidt, M. V.] Max Planck Inst Psychiat, RG Mol Stress Physiol, D-80804 Munich, Germany.
C3 Max Planck Society
RP Schmidt, MV (corresponding author), Max Planck Inst Psychiat, RG Mol Stress Physiol, Kraepelinstr 2-10, D-80804 Munich, Germany.
EM mschmidt@mpipsykl.mpg.de
RI ; Mueller, Marianne/AAL-8911-2021
OI Schmidt, Mathias/0000-0002-3788-2268; Mueller,
   Marianne/0000-0002-0269-6131
CR Branth S, 2007, NUTR METAB CARDIOVAS, V17, P427, DOI 10.1016/j.numecd.2006.03.001
   Day Caroline, 2007, Diab Vasc Dis Res, V4, P32, DOI 10.3132/dvdr.2007.003
   Faith MS, 2002, J PSYCHOSOM RES, V53, P935, DOI 10.1016/S0022-3999(02)00308-2
   Hedley AA, 2004, JAMA-J AM MED ASSOC, V291, P2847, DOI 10.1001/jama.291.23.2847
   Heiskanen TH, 2006, J CLIN PSYCHIAT, V67, P1422, DOI 10.4088/JCP.v67n0913
   Holsboer F, 2000, NEUROPSYCHOPHARMACOL, V23, P477, DOI 10.1016/S0893-133X(00)00159-7
   Ising M, 2007, BIOL PSYCHIAT, V62, P47, DOI 10.1016/j.biopsych.2006.07.039
   Kyrou I, 2007, HORM METAB RES, V39, P430, DOI 10.1055/s-2007-981462
   Masuzaki H, 2001, SCIENCE, V294, P2166, DOI 10.1126/science.1066285
   Ogden CL, 2007, GASTROENTEROLOGY, V132, P2087, DOI 10.1053/j.gastro.2007.03.052
   Räikkönen K, 2007, DIABETES CARE, V30, P872, DOI 10.2337/dc06-1857
   Rosmond R, 1998, INT J OBESITY, V22, P1184, DOI 10.1038/sj.ijo.0800745
   Schmidt MV, 2007, PSYCHONEUROENDOCRINO, V32, P417, DOI 10.1016/j.psyneuen.2007.02.011
   Seckl JR, 2004, CURR OPIN PHARMACOL, V4, P597, DOI 10.1016/j.coph.2004.09.001
   Seematter G, 2004, CURR OPIN CLIN NUTR, V7, P169, DOI 10.1097/00075197-200403000-00011
   Sterlemann V, 2008, HORM BEHAV, V53, P386, DOI 10.1016/j.yhbeh.2007.11.001
   Tamashiro KLK, 2007, PHYSIOL BEHAV, V91, P440, DOI 10.1016/j.physbeh.2007.04.004
   Vogelzangs N, 2007, PSYCHONEUROENDOCRINO, V32, P151, DOI 10.1016/j.psyneuen.2006.11.009
   Weber-Hamann B, 2006, PSYCHONEUROENDOCRINO, V31, P347, DOI 10.1016/j.psyneuen.2005.08.014
NR 19
TC 20
Z9 20
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1025-3890
J9 STRESS
JI Stress
PY 2009
VL 12
IS 1
BP 89
EP 94
AR PII 904805506
DI 10.1080/10253890802049343
PG 6
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA 389QO
UT WOS:000262109800009
PM 18951248
DA 2025-06-11
ER

PT J
AU Kuo, WC
   Oakley, LD
   Brown, RL
   Hagen, EW
   Barnet, JH
   Peppard, PE
   Bratzke, LC
AF Kuo, Wan-chin
   Oakley, Linda D.
   Brown, Roger L.
   Hagen, Erika W.
   Barnet, Jodi H.
   Peppard, Paul E.
   Bratzke, Lisa C.
TI Gender Differences in the Relationship Between Financial Stress and
   Metabolic Abnormalities
SO NURSING RESEARCH
LA English
DT Article
DE dyslipidemia; financial stress; gender differences;
   hypertriglyceridemia; metabolic syndrome; obesity
ID CARDIOVASCULAR-DISEASE; OBESITY; DEPRESSION; OXYTOCIN; DURATION; ADULTS;
   RISK
AB Background
   Financial stress is associated with higher prevalence of metabolic abnormalities and cardiovascular disease, but the extent to which this association differs by type of metabolic abnormalities or gender is unclear. Objectives
   The study aims were (a) to examine the association between financial stress and the prevalence of common metabolic abnormalities and (b) to test the association for gender differences. Methods
   A cross-sectional secondary analysis was conducted using data from the Retirement and Sleep Trajectories study, an ancillary study of the Wisconsin Sleep Cohort study. Composite indicator structural equation alpha modeling with a stacking approach was applied in the data analysis. Results
   After controlling for covariates, financial stress was positively associated with the prevalence of abdominal obesity, metabolic syndrome, and dyslipidemia, with significant gender differences. Among men, financial stress was positively associated with the prevalence of hypertriglyceridemia. Among women, financial stress was positively associated with the prevalence of prediabetes, abdominal obesity, metabolic syndrome, and dyslipidemia. Conclusion
   Men living with financial stress are more likely to have hypertriglyceridemia, a specific metabolic abnormality and risk factor for acute cardiovascular events. However, financial stress in women is associated with a broader array of metabolic abnormalities (e.g., dyslipidemia, prediabetes, abdominal obesity, metabolic syndrome), highlighting a potential risk of multiple chronic conditions later in life.
C1 [Kuo, Wan-chin; Oakley, Linda D.; Brown, Roger L.; Bratzke, Lisa C.] Univ Wisconsin, Sch Nursing, Room 5166,Signe Skott Cooper Hall, Madison, WI 53705 USA.
   [Hagen, Erika W.; Barnet, Jodi H.; Peppard, Paul E.] Univ Wisconsin, Dept Populat Hlth Sci, Sch Med & Publ Hlth, Madison, WI 53705 USA.
C3 University of Wisconsin System; University of Wisconsin Madison;
   University of Wisconsin System; University of Wisconsin Madison
RP Kuo, WC (corresponding author), Univ Wisconsin, Sch Nursing, Room 5166,Signe Skott Cooper Hall, Madison, WI 53705 USA.
EM wkuo4@wisc.edu
RI Kuo, Wan-chin/HHN-6428-2022
OI Kuo, Wan-chin/0000-0002-5658-6077
FU National Institutes of Health [R01HL62252, 1R01AG036838, 1UL1RR02501];
   University of Wisconsin-Madison School of Nursing Johnson Research Award
FX The Wisconsin Sleep Cohort and Retirement and Sleep Trajectories studies
   were supported by grants from the National Institutes of Health:
   R01HL62252, 1R01AG036838, and 1UL1RR02501. This research was awarded by
   the University of Wisconsin-Madison School of Nursing Johnson Research
   Award. The authors would like to thank the volunteers who participated
   in the Wisconsin Sleep Cohort and Retirement and Sleep Trajectories
   studies. Editorial support was provided by Joe Wszalek, JD, PhD, the
   Scientific Writing and Scholarship program director at the University of
   Wisconsin-Madison School of Nursing. The authors also thank Anne Ersig,
   RN, PhD, for her contribution to the revision and editing of this
   article.
CR Agrigoroaei S, 2017, RES AGING, V39, P1075, DOI 10.1177/0164027516658502
   Ali L, 2018, CURR OPIN LIPIDOL, V29, P475, DOI 10.1097/MOL.0000000000000550
   Amrock SM, 2017, ATHEROSCLEROSIS, V267, P19, DOI 10.1016/j.atherosclerosis.2017.10.006
   [Anonymous], 2010, MPlus Web Notes
   Bethune S., 2015, Monitor of Psychology, V46, P38
   Beydoun MA, 2014, J NUTR, V144, P1139, DOI 10.3945/jn.114.196717
   Block JP, 2009, AM J EPIDEMIOL, V170, P181, DOI 10.1093/aje/kwp104
   Brown DR, 2015, SOC SCI MED, V133, P202, DOI 10.1016/j.socscimed.2015.03.058
   Byrne B.M., 1998, Multivariate applications book series. Structural equation modeling with LISREL, PRELIS, and SIMPLIS: Basic concepts, applications
   Carlsson AC, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-17
   Conklin AI, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-1039
   Cosgrove MP, 2012, OCCUP MED-OXFORD, V62, P167, DOI 10.1093/occmed/kqs002
   Epel ES, 2018, FRONT NEUROENDOCRIN, V49, P146, DOI 10.1016/j.yfrne.2018.03.001
   Epel ES, 2006, PSYCHONEUROENDOCRINO, V31, P277, DOI 10.1016/j.psyneuen.2005.08.011
   Fava GA, 2019, PSYCHONEUROENDOCRINO, V108, P94, DOI 10.1016/j.psyneuen.2019.05.028
   Hagen EW, 2016, SLEEP, V39, P665, DOI 10.5665/sleep.5548
   Herpolsheimer L.J., 2015, FINANCIAL STRESS OLD
   Holland K., 2019, FINANCIAL STRESS WEL
   Karatsoreos IN, 2011, TRENDS COGN SCI, V15, P576, DOI 10.1016/j.tics.2011.10.005
   Khera R, 2018, JAMA CARDIOL, V3, P729, DOI 10.1001/jamacardio.2018.1813
   Kuo WC, 2019, OBES REV, V20, P1651, DOI 10.1111/obr.12915
   Lawson EA, 2017, NAT REV ENDOCRINOL, V13, P700, DOI 10.1038/nrendo.2017.115
   Lewinsohn PM, 1997, PSYCHOL AGING, V12, P277, DOI 10.1037/0882-7974.12.2.277
   Li CH, 2016, BEHAV RES METHODS, V48, P936, DOI 10.3758/s13428-015-0619-7
   Lin TH, 2010, QUAL QUANT, V44, P277, DOI 10.1007/s11135-008-9196-5
   Love TM, 2018, CURR OPIN BEHAV SCI, V23, P136, DOI 10.1016/j.cobeha.2018.06.018
   McDonald R., 2005, Journal of Academy of Business and Economics, V5, P80
   McEwen BS, 2020, HORM BEHAV, V119, DOI 10.1016/j.yhbeh.2019.104619
   MCKELVEY RD, 1975, J MATH SOCIOL, V4, P103, DOI 10.1080/0022250X.1975.9989847
   McKenzie SK, 2018, AM J MENS HEALTH, V12, P1247, DOI 10.1177/1557988318772732
   Medicare.gov, MEDICARE COVERAGE CA
   Mongraw-Chaffin M, 2016, J CLIN ENDOCR METAB, V101, P4117, DOI 10.1210/jc.2016-2460
   Muthen B. O., 1998, MPLUS USERS GUIDE
   National Endowment for Financial Education, 2020, COVID 19 SURV
   National Institute of Nursing Research, NINR INN QUEST IQ IN
   Pan LP, 2012, J ACAD NUTR DIET, V112, P1403, DOI 10.1016/j.jand.2012.06.011
   Peppard PE, 2013, AM J EPIDEMIOL, V177, P1006, DOI 10.1093/aje/kws342
   Phillips CM, 2017, ANN NY ACAD SCI, V1391, P85, DOI 10.1111/nyas.13230
   Plante DT, 2017, J AFFECT DISORDERS, V207, P197, DOI 10.1016/j.jad.2016.08.039
   SAS Institute Inc, 2020, SAS IML 9 4 PROGR BO
   Shah AK, 2015, PSYCHOL SCI, V26, P402, DOI 10.1177/0956797614563958
   Shah AK, 2012, SCIENCE, V338, P682, DOI 10.1126/science.1222426
   Sommers BD, 2013, J HEALTH ECON, V32, P816, DOI 10.1016/j.jhealeco.2013.06.005
   Steen A, 2013, AUSTRALAS ACCOUNT BU, V7, DOI 10.14453/aabfj.v7i3.3
   Sui H, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0159978
   Taylor Jasmine L, 2018, Gend Genome, V2, P111, DOI 10.1177/2470289718820845
   Tenk J, 2018, PSYCHONEUROENDOCRINO, V95, P63, DOI 10.1016/j.psyneuen.2018.05.014
   Thrane C., 2019, APPL REGRESSION ANAL, V1st, P120
   VEALL MR, 1994, QUAL QUANT, V28, P151, DOI 10.1007/BF01102759
   Winter J, 2019, CELL TISSUE RES, V375, P85, DOI 10.1007/s00441-018-2866-2
NR 50
TC 6
Z9 6
U1 1
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0029-6562
EI 1538-9847
J9 NURS RES
JI Nurs. Res.
PD MAR-APR
PY 2021
VL 70
IS 2
BP 123
EP 131
DI 10.1097/NNR.0000000000000489
PG 9
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA SL0BI
UT WOS:000656581400009
PM 33630535
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Nilsson, A
   Salo, I
   Plaza, M
   Björck, I
AF Nilsson, Anne
   Salo, Ilkka
   Plaza, Merichel
   Bjorck, Inger
TI Effects of a mixed berry beverage on cognitive functions and
   cardiometabolic risk markers; A randomized cross-over study in healthy
   older adults
SO PLOS ONE
LA English
DT Article
ID SUPPLEMENTATION IMPROVES MEMORY; ANTIOXIDANT CAPACITY; WORKING-MEMORY;
   LIQUID-CHROMATOGRAPHY; UNIVERSAL RESPONSE; METABOLIC SYNDROME; INSULIN;
   MEN; DISEASE; GLUCOSE
AB Background
   Berries and associated bioactive compounds, e.g. polyphenols and dietary fibre (DF), may have beneficial implications with respect to the metabolic syndrome, including also cognitive functions. The aim of this study was to evaluate effects on cognitive functions and cardiometabolic risk markers of 5 wk intervention with a mixture of berries, in healthy humans.
   Methods
   Forty healthy subjects between 50-70 years old were provided a berry beverage based on a mixture of berries (150g blueberries, 50g blackcurrant, 50g elderberry, 50g lingonberries, 50g strawberry, and 100g tomatoes) or a control beverage, daily during 5 weeks in a randomized crossover design. The control beverage (water based) was matched with respect to monosaccharides, pH, and volume. Cognitive tests included tests of working memory capacity, selective attention, and psychomotor reaction time. Cardiometabolic test variables investigated were blood pressure, fasting blood concentrations of glucose, insulin, blood lipids, inflammatory markers, and markers of oxidative stress. Results
   The daily amounts of total polyphenols and DF from the berry beverage were 795 mg and 11g, respectively. There were no polyphenols or DF in the control beverage. The berry intervention reduced total- and LDL cholesterol compared to baseline (both P<0.05), and in comparison to the control beverage (P<0.005 and P<0.01, respectively). The control beverage increased glucose concentrations (P<0.01) and tended to increase insulin concentrations (P = 0.064) from base line, and increased insulin concentrations in comparison to the berry beverage (P<0.05). Subjects performed better in the working memory test after the berry beverage compared to after the control beverage (P<0.05). No significant effects on the other test variables were observed.
   Conclusions
   The improvements in cardiometabolic risk markers and cognitive performance after the berry beverage suggest preventive potential of berries with respect to type 2 diabetes, cardiovascular disease, and associated cognitive decline. Possibly the polyphenols and DF contributed to the beneficial effects.
C1 [Nilsson, Anne; Bjorck, Inger] Lund Univ, Food Hlth Sci Ctr, Lund, Sweden.
   [Nilsson, Anne] Lund Univ, Dept Food Technol Engn & Nutr, Lund, Sweden.
   [Salo, Ilkka] Lund Univ, Dept Psychol, Lund, Sweden.
   [Plaza, Merichel] Lund Univ, Dept Chem, Ctr Anal & Synth, Lund, Sweden.
   [Plaza, Merichel] Univ Alcala, Dept Analyt Chem Phys Chem & Chem Engn, Madrid, Spain.
C3 Lund University; Lund University; Lund University; Lund University;
   Universidad de Alcala
RP Nilsson, A (corresponding author), Lund Univ, Food Hlth Sci Ctr, Lund, Sweden.; Nilsson, A (corresponding author), Lund Univ, Dept Food Technol Engn & Nutr, Lund, Sweden.
EM anne.nilsson@food-health-science.lu.se
RI Nilsson, Anne/AIA-0822-2022; Plaza, Merichel/J-6770-2013
OI Salo, Ilkka/0000-0003-0943-5484; Nilsson, Anne/0000-0002-9780-7876;
   Plaza, Merichel/0000-0002-9636-6458
FU Antidiabetic Food Centre, a VINNOVA VINN Excellence Center at Lund
   University [2009-04511]
FX This study was supported by the Antidiabetic Food Centre, a VINNOVA VINN
   Excellence Center at Lund University (grant no. 2009-04511). The funders
   had no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript. URL:
   http://www.food-health-science.lu.se/en/afc.
CR Basu A, 2010, J NUTR, V140, P1582, DOI 10.3945/jn.110.124701
   Bielli A, 2015, LIFE SCI, V143, P209, DOI 10.1016/j.lfs.2015.11.012
   Brand-Miller JC, 2003, NUTR REV, V61, pS49, DOI 10.1301/nr.2003.may.S49-S55
   Cani PD, 2013, CURR OPIN PHARMACOL, V13, P935, DOI 10.1016/j.coph.2013.09.008
   Chen L, 2014, J SCI FOOD AGR, V94, P180, DOI 10.1002/jsfa.6216
   Chiou JF, 1999, CLIN BIOCHEM, V32, P189, DOI 10.1016/S0009-9120(98)00110-6
   Ciocoiu M, 2016, PHARM BIOL, P1
   DANEMAN M, 1980, J VERB LEARN VERB BE, V19, P450, DOI 10.1016/S0022-5371(80)90312-6
   de Villiers A, 2007, J CHROMATOGR A, V1161, P183, DOI 10.1016/j.chroma.2007.05.078
   Devore EE, 2013, AM J EPIDEMIOL, V177, P33, DOI 10.1093/aje/kws202
   Devore EE, 2012, ANN NEUROL, V72, P135, DOI 10.1002/ana.23594
   Edirisinghe I, 2011, BRIT J NUTR, V106, P913, DOI 10.1017/S0007114511001176
   Engle R.W., 1999, Models of Working Memory: Mechanisms of Active Maintenance and Executive Control, P102, DOI 10.1017/CBO9781139174909.007
   Erlund I, 2008, AM J CLIN NUTR, V87, P323, DOI 10.1093/ajcn/87.2.323
   Escudero-López B, 2013, J AGR FOOD CHEM, V61, P8773, DOI 10.1021/jf401240p
   Faria A, 2014, FOOD CHEM, V149, P190, DOI 10.1016/j.foodchem.2013.10.095
   Gammone MA, 2015, FOOD NUTR RES, V59, DOI 10.3402/fnr.v59.26762
   Gorecki T, 2006, ANAL CHEM, V78, P3186, DOI 10.1021/ac060078j
   Grooms KN, 2013, AM J MED, V126, P1059, DOI 10.1016/j.amjmed.2013.07.023
   Heinonen IM, 1998, J AGR FOOD CHEM, V46, P25, DOI 10.1021/jf970489o
   Horszwald A, 2011, J BERRY RES, V1, P189, DOI 10.3233/BR-2011-020
   Hosseinpour-Niazi S, 2012, ARCH IRAN MED, V15, P538, DOI 012159/AIM.005
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Huang HH, 2016, SCI REP-UK, V6, DOI 10.1038/srep23625
   Kähkönen MP, 2003, J SCI FOOD AGR, V83, P1403, DOI 10.1002/jsfa.1511
   Kosar M, 2005, FOOD CHEM, V91, P525, DOI 10.1016/j.foodchem.2004.06.029
   Kovatcheva-Datchary P, 2015, CELL METAB, V22, P971, DOI 10.1016/j.cmet.2015.10.001
   Krikorian R, 2010, J AGR FOOD CHEM, V58, P3996, DOI 10.1021/jf9029332
   Krikorian R, 2010, BRIT J NUTR, V103, P730, DOI 10.1017/S0007114509992364
   Kyllonen PC, 1996, HUMAN ABILITIES, P49
   Li W, 2016, J ALZHEIMERS DIS, V53, P393, DOI 10.3233/JAD-160114
   Lim DW, 2016, NUTRIENTS, V8, DOI 10.3390/nu8120760
   Magalhaes LM, 2008, ANAL CHIM ACTA, V613, P1, DOI 10.1016/j.aca.2008.02.047
   Mane C, 2011, J AGR FOOD CHEM, V59, P3330, DOI 10.1021/jf103965b
   Matthews D R., Homeostasis model assessment: Insulin resistance and fl-cell function from fasting plasma glucose and insulin concentrations in man
   McIntyre RS, 2012, BEHAV BRAIN RES
   Mitic MN, 2011, HEM IND, V65, P611, DOI 10.2298/HEMIND110418042M
   Molinett S, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/320136
   Mursu J, 2014, AM J CLIN NUTR, V99, P328, DOI 10.3945/ajcn.113.069641
   Nilsson A, 2009, EUR J CLIN NUTR, V63, P113, DOI 10.1038/sj.ejcn.1602900
   Nilsson AC, 2015, BR J NUTR, P1
   Nilsson A, 2013, NUTR METAB, V10, DOI 10.1186/1743-7075-10-49
   Ötles S, 2014, ACTA SCI POLON-TECHN, V13, P191, DOI 10.17306/J.AFS.2014.2.8
   Park J. H., 2015, EVID-BASED COMPL ALT, V2015
   Parkar SG, 2013, ANAEROBE, V23, P12, DOI 10.1016/j.anaerobe.2013.07.009
   Perez-Jimenez J, EJCN S3, V64, pS112
   Plaza M, 2014, J AGR FOOD CHEM, V62, P409, DOI 10.1021/jf404263k
   Pounis G, 2015, THROMB HAEMOST, V115
   Radeborg K, 1999, ERGONOMICS, V42, P767, DOI 10.1080/001401399185441
   Raffaitin C, 2011, NEUROLOGY, V76, P518, DOI 10.1212/WNL.0b013e31820b7656
   Rao AV, 2007, PHARMACOL RES, V55, P207, DOI 10.1016/j.phrs.2007.01.012
   Re R, 1999, FREE RADICAL BIO MED, V26, P1231, DOI 10.1016/S0891-5849(98)00315-3
   Rissanen TH, 2003, J NUTR, V133, P199, DOI 10.1093/jn/133.1.199
   Singleton VL, 1999, METHOD ENZYMOL, V299, P152
   Sparkman NL, 2006, J NEUROSCI, V26, P10709, DOI 10.1523/JNEUROSCI.3376-06.2006
   Spencer JPE, 2012, MOL ASPECTS MED, V33, P83, DOI 10.1016/j.mam.2011.10.016
   Ströher DJ, 2015, INT J FOOD SCI NUTR, V66, P559, DOI 10.3109/09637486.2015.1064870
   Stull AJ, 2010, J NUTR, V140, P1764, DOI 10.3945/jn.110.125336
   Taylor VH, 2007, OBES REV, V8, P409, DOI 10.1111/j.1467-789X.2007.00401.x
   Törrönen R, 2012, AM J CLIN NUTR, V96, P527, DOI 10.3945/ajcn.112.042184
   Törrönen R, 2010, BRIT J NUTR, V103, P1094, DOI 10.1017/S0007114509992868
   Tuberoso CIG, 2013, FOOD CHEM, V140, P686, DOI 10.1016/j.foodchem.2012.09.071
   Wang B, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0095323
   Yamashita S, 2009, CLIN CHIM ACTA, V410, P31, DOI 10.1016/j.cca.2009.09.010
   Ye EQ, 2012, J NUTR, V142, P1304, DOI 10.3945/jn.111.155325
   Yin QQ, 2014, NEUROPHARMACOLOGY, V86, P389, DOI 10.1016/j.neuropharm.2014.07.020
   Zhao WQ, 2001, MOL CELL ENDOCRINOL, V177, P125, DOI 10.1016/S0303-7207(01)00455-5
NR 67
TC 67
Z9 70
U1 1
U2 29
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 15
PY 2017
VL 12
IS 11
AR e0188173
DI 10.1371/journal.pone.0188173
PG 22
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FM7MC
UT WOS:000415260400067
PM 29141041
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mayhew, M
   Smith, N
   Fortmann, SP
   Fitzpatrick, SL
AF Mayhew, Meghan
   Smith, Ning
   Fortmann, Stephen P.
   Fitzpatrick, Stephanie L.
TI Mental health diagnosis attenuates weight loss among older adults in a
   digital diabetes prevention program
SO OBESITY SCIENCE & PRACTICE
LA English
DT Article
DE diabetes prevention; lifestyle intervention; mental health
ID PSYCHIATRIC-DISORDERS; METABOLIC SYNDROME; DEPRESSION; OBESITY;
   INDIVIDUALS; VALIDATION; ASSOCIATION; OUTCOMES; RISK; LIFE
AB Objective: Diabetes Prevention Programs (DPP) are effective at reducing diabetes incidence via clinically significant weight loss. Co-morbid mental health condition(s) may reduce the effect of DPP administered in-person and telephonically but this has not been assessed for digital DPP. This report examines the moderating effect of mental health diagnosis on weight change among individuals who enrolled in digital DPP (enrollees) at 12 and 24 months.
   Methods: Secondary analysis of prospective, electronic health record data from a study of digital DPP among adults (N = 3904) aged 65-75 with prediabetes (HbA1c 5.7%-6.4%) and obesity (BMI >= 30 kg/m(2)).
   Results: Mental health diagnosis only moderated the effect of digital DPP on weight change during the first 7 months (p = 0.003) and the effect attenuated at 12 and 24 months. Results were unchanged after adjusting for psychotropic medication use. Among those without a mental health diagnosis, digital DPP enrollees lost more weight than non-enrollees: -4.17 kg (95% CI, -5.22 to -3.13) at 12 months and -1.88 kg (95% CI, -3.00 to -0.76) at 24 months, whereas among individuals with a mental health diagnosis, there was no difference in weight loss between enrollees and non-enrollees at 12 and 24 months (-1.25 kg [95% CI, -2.77 to 0.26] and 0.02 kg [95% CI, -1.69-1.73], respectively).
   Conclusions: Digital DPP appears less effective for weight loss among individuals with a mental health condition, similar to prior findings for in-person and telephonic modalities. Findings suggest a need for tailoring DPP to address mental health conditions.
C1 [Mayhew, Meghan; Smith, Ning; Fortmann, Stephen P.; Fitzpatrick, Stephanie L.] Kaiser Permanente Ctr Hlth Res Northwest Portland, 3800 N Interstate Ave, Portland, OR 97227 USA.
RP Mayhew, M (corresponding author), Kaiser Permanente Ctr Hlth Res Northwest Portland, 3800 N Interstate Ave, Portland, OR 97227 USA.
EM Meghan.H.Mayhew@kpchr.org
OI Fitzpatrick, Stephanie/0000-0003-2740-5502
FU National Institutes of Health (NIH), National Institute of Diabetes and
   Digestive and Kidney Diseases (NIDDK) [1R01DK115237]
FX This study is supported by the National Institutes of Health (NIH),
   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
   (Project Number: 1R01DK115237).
CR Agha M, 2017, INT J SURG-ONCOL, V2, DOI [10.1097/IJ9.0000000000000017, 10.1097/IJ9.0000000000000019]
   Alhalel N, 2018, OBES SCI PRACT, V4, P153, DOI 10.1002/osp4.157
   Beran M, 2022, DIABETIC MED, V39, DOI 10.1111/dme.14671
   Breland JY, 2020, PSYCHIAT SERV, V71, P506, DOI 10.1176/appi.ps.201900078
   Castro A, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph182413268
   CHARLSON M, 1994, J CLIN EPIDEMIOL, V47, P1245, DOI 10.1016/0895-4356(94)90129-5
   Chen F, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0163627
   Chen SG, 2016, ENDOCRINE, V53, P35, DOI 10.1007/s12020-016-0869-x
   Cudjoe Thomas K M, 2020, J Gerontol B Psychol Sci Soc Sci, V75, P107, DOI 10.1093/geronb/gby037
   Di Angelantonio E, 2016, LANCET, V388, P776, DOI 10.1016/S0140-6736(16)30175-1
   Diabetes Prevention Program Research Group, 2009, Lancet, V374, P1677, DOI 10.1016/S0140-6736(09)61457-4
   DiMaria-Ghalili RA, 2006, BIOL RES NURS, V8, P15, DOI 10.1177/1099800406288903
   Fitzpatrick Stephanie L, 2022, Clin Diabetes, V40, P345, DOI 10.2337/cd21-0114
   Fitzpatrick Stephanie L, 2021, Perm J, V26, P21, DOI 10.7812/TPP/21.056
   Golden SH, 2008, JAMA-J AM MED ASSOC, V299, P2751, DOI 10.1001/jama.299.23.2751
   Golovaty I, 2021, BMC PUBLIC HEALTH, V21, DOI 10.1186/s12889-021-11378-4
   Gruss I, 2022, OBES SCI PRACT, V8, P176, DOI 10.1002/osp4.562
   Haigh EAP, 2018, AM J GERIAT PSYCHIAT, V26, P107, DOI 10.1016/j.jagp.2017.06.011
   Janney CA, 2018, GEN HOSP PSYCHIAT, V53, P32, DOI 10.1016/j.genhosppsych.2018.04.001
   Janney CA, 2017, J AFFECT DISORDERS, V215, P197, DOI 10.1016/j.jad.2017.03.003
   Leo Michael C, 2014, EGEMS (Wash DC), V2, P1051, DOI 10.13063/2327-9214.1051
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Moin T, 2018, AM J PREV MED, V55, P583, DOI 10.1016/j.amepre.2018.06.028
   Pagoto S, 2013, INT J OBESITY, V37, P1427, DOI 10.1038/ijo.2013.25
   Patterson RE, 2004, AM J PREV MED, V27, P385, DOI 10.1016/j.amepre.2004.08.001
   Pratt Laura A, 2014, NCHS Data Brief, P1
   Quinones MM, 2018, TRANSL BEHAV MED, V8, P195, DOI 10.1093/tbm/ibx064
   Rajan TM, 2017, J POSTGRAD MED, V63, P182, DOI 10.4103/jpgm.JPGM_712_16
   Rosen-Reynoso M, 2011, EAT BEHAV, V12, P1, DOI 10.1016/j.eatbeh.2010.08.008
   Schneider Kristin L, 2011, Transl Behav Med, V1, P453, DOI 10.1007/s13142-011-0053-z
   Sepah SC, 2017, BMJ OPEN DIAB RES CA, V5, DOI 10.1136/bmjdrc-2017-000422
   Sepah SC, 2014, DIABETES EDUCATOR, V40, P435, DOI 10.1177/0145721714531339
   Srebnik D, 2015, PSYCHIAT SERV, V66, P200, DOI 10.1176/appi.ps.201300576
   STEVENS VJ, 1988, ADDICT BEHAV, V13, P171, DOI 10.1016/0306-4603(88)90007-X
   Stierman Bryan, 2021, Natl Health Stat Report, DOI 10.15620/cdc:106273
   Sweet CMC, 2018, J AGING HEALTH, V30, P692, DOI 10.1177/0898264316688791
   Tabák AG, 2014, LANCET DIABETES ENDO, V2, P236, DOI 10.1016/S2213-8587(13)70139-6
   Tabák AG, 2012, LANCET, V379, P2279, DOI 10.1016/S0140-6736(12)60283-9
   Trief PM, 2014, OBESITY, V22, P2532, DOI 10.1002/oby.20916
   Tsenkova VK, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0164802
   Walburg FS, 2022, BMC HEALTH SERV RES, V22, DOI 10.1186/s12913-021-07391-3
   Wang Q, 2017, INT J CARDIOL, V230, P461, DOI 10.1016/j.ijcard.2016.12.084
   Xiao L, 2017, OBESITY, V25, P363, DOI 10.1002/oby.21737
   Yarborough BJH, 2016, PSYCHIATR REHABIL J, V39, P33, DOI 10.1037/prj0000151
   Yu M, 2015, CAN J DIABETES, V39, P266, DOI 10.1016/j.jcjd.2014.11.006
NR 45
TC 1
Z9 1
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2055-2238
J9 OBES SCI PRACT
JI OBES. SCI. PRACT.
PD JUN
PY 2023
VL 9
IS 3
BP 320
EP 326
DI 10.1002/osp4.644
EA NOV 2022
PG 7
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA I1TL1
UT WOS:000876939300001
PM 37287521
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Dzampaeva, Z
   Datieva, F
   Takoeva, E
   Nartikoeva, M
AF Dzampaeva, Zhanna
   Datieva, Fatima
   Takoeva, Elena
   Nartikoeva, Marina
TI BEHAVIORAL ACTIVITY IN EXPERIMENTAL METABOLIC SYNDROME AND DURING
   TREATMENT WITH COMPLEX PHYTOADAPTOGENS
SO ARCHIV EUROMEDICA
LA English
DT Article
DE Acanthopanax senticosus; dyslipidemia; Glycyrrhiza glabra; hypertension;
   insulin resistance; metabolic syndrome; obesity; Rhodiola rosea
ID LEPTIN
AB The aim of the study was to evaluate behavioral disorders in experimental metabolic syndrome and the possibility of treatment with complex phytoadaptogens (CPhA). The experiment was carried out on 30 male Wistar rats randomly divided into 3 groups: control (Group 1), metabolic syndrome (MS, Group 2), and treatment of metabolic syndrome with CPhA (Group 3). In Groups 2 and 3, the animals were on a diet high in carbohydrates and fats for 16 weeks. Group 3 animals received CPhA for 14 days with drinking water after 16 weeks of the diet. CPhA consist of standard tinctures of Glycyrrhiza glabra, Rhodiola rosea, Acantopanax senticosus in a ratio of 1:2:1. Behavior was analyzed in the open field test (OFT) and the elevated plus maze (EPM), using Realtimer software (OpenScience, Russia). Data were analyzed using GrafPadPrism 8.03 software (USA). The experiment demonstrated that metabolic syndrome is associated with increased anxiety (decrease in horizontal (p=0.017) and vertical (p=0.017) locomotor activity) and fear (increase in immobility time (p=0.011)) in the OFT. Increased anxiety of animals (decreased open arm time (p=0.012) and increased closed arm time (p=0.043)) and emotional stress (increased frequency of defecation (0.017)) relative to control are also confirmed by EPM data. The data obtained in the treatment group (no significant differences with the control), i.e., a decrease in the manifestations of fear and anxiety (increased orientation and exploratory activity), indicate that the complex phytoadaptogens are an effective anxiolytic. The mechanisms that led to this result remain to be explored, highlighting the role of the autonomic nervous system, leptin and ghrelin in behavior and the effect of the complex phytoadaptogens on them.
C1 [Dzampaeva, Zhanna; Datieva, Fatima; Takoeva, Elena; Nartikoeva, Marina] Russian Acad Sci, Dept Chronopathophysiol & Phytopharmacol, Inst Biomed Res, Vladikavkaz Sci Ctr, Moscow, Russia.
C3 Russian Academy of Sciences; Institute of Biomedical Problems of the
   Russian Academy of Sciences; Vladikavkaz Scientific Center
RP Dzampaeva, Z (corresponding author), Russian Acad Sci, Dept Chronopathophysiol & Phytopharmacol, Inst Biomed Res, Vladikavkaz Sci Ctr, Moscow, Russia.
EM dzhanaeva_1991@mail.ru
RI Elena, Takoeva/ABX-7177-2022; Dzampaeva, Zhanna/ABA-4269-2020
OI Takoeva, Elena/0000-0001-7248-5244; Nartikoeva,
   Marina/0000-0001-9235-7303; Dzampaeva, Zhanna/0000-0002-0778-5117
CR Afshin A, 2017, NEW ENGL J MED, V377, P13, DOI 10.1056/NEJMoa1614362
   Arushanyan E.B., 2009, PHYTHOADAPTOGENS STA
   BureshYa, 1991, METHODS BASIC EXPT S
   Hasan MK, 2021, HELIYON, V7, DOI 10.1016/j.heliyon.2021.e07240
   Lavallee KL, 2021, FRONT PSYCHOL, V12, DOI 10.3389/fpsyg.2021.712567
   Lee OH, 2011, PHYTOTHER RES, V25, P106, DOI 10.1002/ptr.3236
   Li ZK, 2018, CALCIFIED TISSUE INT, V103, P324, DOI 10.1007/s00223-018-0425-1
   Marazziti D, 2014, CNS SPECTRUMS, V19, P293, DOI 10.1017/S1092852913000667
   Monserrat-Mesquida M, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9030236
   Mulkey SB, 2019, PEDIATR RES, V85, P120, DOI 10.1038/s41390-018-0155-0
   Panossian A, 2019, PHYTOMEDICINE, V60, DOI 10.1016/j.phymed.2019.152881
   Panossian AG, 2021, MED RES REV, V41, P630, DOI 10.1002/med.21743
   Pape HC, 2010, PHYSIOL REV, V90, P419, DOI 10.1152/physrev.00037.2009
   Pezze MA, 2004, PROG NEUROBIOL, V74, P301, DOI 10.1016/j.pneurobio.2004.09.004
   Sadock B.J., 2000, Kaplan Sadock's comprehensive textbook of psychiatry, V7th
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Scarpace PJ, 2013, NEUROPHARMACOLOGY, V65, P90, DOI 10.1016/j.neuropharm.2012.09.005
   Tian C, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/7398453
   Zhang Y, 2006, PHYSIOL BEHAV, V88, P249, DOI 10.1016/j.physbeh.2006.05.038
   Zheng Y, 2020, J MED FOOD, V23, P215, DOI 10.1089/jmf.2019.4660
NR 20
TC 0
Z9 0
U1 0
U2 0
PU EUROPAISCHE WISSENSCHAFTLICHE GESELLSCHAFT EV
PI HANNOVER
PA SUTELSTR 50A, HANNOVER, 30659, GERMANY
SN 2193-3863
EI 2199-885X
J9 ARCH EUROMEDICA
JI Arch. EuroMedica
PY 2022
VL 12
IS 6
DI 10.35630/2022/12/6.5
PG 7
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA C4SD2
UT WOS:000961821400006
OA Bronze
DA 2025-06-11
ER

PT J
AU Todaro, JF
   Shen, BJ
   Niaura, R
   Spiro, A
   Ward, KD
AF Todaro, JF
   Shen, BJ
   Niaura, R
   Spiro, A
   Ward, KD
TI Effect of negative emotions on frequency of coronary heart disease (The
   Normative Aging Study)
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID DEPRESSION; MORTALITY; SYMPTOMS; ADULTS; PLASMA; RISK
AB Negative emotions, such as depression and anxiety, have been associated with the development of coronary heart disease (CHD). In multivariate models, negative emotions have predicted CHD outcomes, such as nonfatal myocardial infarction and CHD mortality. Few studies, however, have investigated this relation while controlling for variables associated with the metabolic syndrome or those indicative of sympathetic nervous system activity. We prospectively examined the relation between negative emotions and incident CHD in older men (mean 60.3 +/- 7.9 years) participating in the Normative Aging Study (NAS). Four hundred ninety-eight men who completed the Minnesota Multiphasic Personality Inventory (MMPI) and who participated in a subsequent laboratory assessment were included in the study. All men were not on medication and free of diagnosed CHD and diabetes. Negative emotions were measured by the MMPI Welsh A scale, which is comprised of 39 items measuring symptoms of depression and anxiety. Negative emotion score, sociodemographic characteristics, health behaviors, components of the metabolic syndrome, and stress hormones were used to predict incident CHD over a 3-year follow-up period. During follow-up, 45 CHD events were observed. In unadjusted logistic regression analyses, negative emotions significantly predicted the incidence of CHD (odds ratio [OR] 1.06, 95% confidence interval [CI] 1.01 to 1.10, p = 0.02). After adjusting for potential covariates, negative emotions continued to predict the incidence of CHD (OR 1.06, 95% CI 1.01 to 1.12, p = 0.02) A linear, dose-response relation was observed (chi-square 10.8, degree of freedom 2, p = 0.005): participants who had the highest level of negative emotions experienced the greatest incidence of CHD. (C) 2003 by Excerpta Medica, Inc.
C1 Miriam Hosp, Providence, RI 02903 USA.
   Brown Med Sch, Ctr Behav & Prevent Med, Providence, RI 02903 USA.
   Univ Miami, Dept Psychol, Miami, FL USA.
   Boston Univ, Sch Publ Hlth, Boston, MA USA.
   MAVERIC, Boston VA Healthcare Syst, Boston, MA USA.
   Univ Memphis, Ctr Community Hlth, Memphis, TN 38152 USA.
C3 Lifespan Health Rhode Island; Miriam Hospital; Brown University;
   University of Miami; Boston University; Harvard University; Harvard
   University Medical Affiliates; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); VA Boston Healthcare System;
   University of Memphis
RP Todaro, JF (corresponding author), Brown Med Sch, Ctr Behav & Prevent Med, Coro Bldg,Suite 500,1 Hoppin St, Providence, RI 02903 USA.
RI She, Ji/AAW-6150-2021; Niaura, Raymond/AAE-7319-2019
OI Spiro III, Avron/0000-0003-4080-8621
FU NHLBI NIH HHS [HL37871, 5K23 HL004473-02] Funding Source: Medline; NIA
   NIH HHS [AG02287] Funding Source: Medline
CR ANDA R, 1993, EPIDEMIOLOGY, V4, P285, DOI 10.1097/00001648-199307000-00003
   [Anonymous], 1989, MMPI 2 MINNESOTA MUL
   Barefoot JC, 1996, CIRCULATION, V93, P1976, DOI 10.1161/01.CIR.93.11.1976
   BOSSE R, 1984, VETERAN ADM NORMATIV
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   KAWACHI I, 1994, CIRCULATION, V90, P2225, DOI 10.1161/01.CIR.90.5.2225
   Kubzansky LD, 1997, CIRCULATION, V95, P818
   LEON LP, 1977, MORE SPECIFIC METHOD, P12
   MACDONALD IA, 1985, J NEUROSCI METH, V13, P239, DOI 10.1016/0165-0270(85)90072-X
   Schulz R, 2000, ARCH INTERN MED, V160, P1761, DOI 10.1001/archinte.160.12.1761
   SHURTLEFF D, 1974, PHS PUBLICATION, V1693
   SMEDES F, 1982, J CHROMATOGR, V231, P25, DOI 10.1016/S0378-4347(00)80506-X
   WELSH GS, 1965, J CLIN PSYCHOL, V21, P43, DOI 10.1002/1097-4679(196501)21:1<43::AID-JCLP2270210113>3.0.CO;2-O
   WILLETT WC, 1985, AM J EPIDEMIOL, V122, P51, DOI 10.1093/oxfordjournals.aje.a114086
NR 14
TC 65
Z9 78
U1 0
U2 11
PU EXCERPTA MEDICA INC
PI NEW YORK
PA 650 AVENUE OF THE AMERICAS, NEW YORK, NY 10011 USA
SN 0002-9149
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD OCT 15
PY 2003
VL 92
IS 8
BP 901
EP 906
DI 10.1016/S0002-9149(03)00967-6
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 732DW
UT WOS:000185926400001
PM 14556863
DA 2025-06-11
ER

PT J
AU Casseb, GAS
   Ambrósio, G
   Rodrigues, ALS
   Kaster, MP
AF Casseb, Gleicilaine A. S.
   Ambrosio, Gabriela
   Rodrigues, Ana Lucia S.
   Kaster, Manuella P.
TI Levels of 25-hydroxyvitamin D3, biochemical parameters and
   symptoms of depression and anxiety in healthy individuals
SO METABOLIC BRAIN DISEASE
LA English
DT Article
DE Anxiety; Depression; Glucose; Lipid profile; Vitamin D
ID VITAMIN-D-RECEPTOR; TRAIT ANXIETY; PARATHYROID-HORMONE; D
   SUPPLEMENTATION; METABOLIC SYNDROME; DOUBLE-BLIND; RISK; STATE;
   PORTUGUESE; CALCIUM
AB Growing evidence support the role of vitamin D in brain function and behavior. This study investigated the relationship between 25-hydroxyvitamin D-3 [25(OH)D-3] levels, biochemical profile and symptoms of depression and anxiety in healthy individuals. Symptoms of depression were assessed by the Beck Depression Inventory (BDI) and anxiety was evaluated with the State-Trait Anxiety Inventory (STAI). Our sample included 36 individuals, mostly women 27(75%), 36.39 +/- 9.72years old, non-smokers 31(86.1%), body mass index of 26.57 +/- 3.92kg/m(2), 27.95 +/- 7.50% body fat. Participants were divided into those with 25(OH)D-3 levels lower than 40ng/mL (mean 28.16 +/- 7.07) and equal or higher than 40ng/mL (mean 53.19 +/- 6.32). Those with lower 25(OH)D-3 had higher levels of triacylglycerol, triacylglycerol/high density lipoprotein (HDL) ratio, high glucose and homeostatic model assessment of insulin resistance (HOMA-IR) index. No changes were observed in sociodemographic variables, body composition, inflammatory parameters and cortisol. Additionally, in the groups with low and high 25(OH)D-3 levels, STAI state, STAI trait and BDI scores were not statistically different. Levels of 25(OH)D-3 were inversely and independently associated with glucose and HOMA-IR, but not associated with triacylglycerol, depression and anxiety scores. Lower levels of 25(OH)D-3 were associated with dysfunction in glucose metabolism but not with depression and anxiety in healthy individuals.
C1 [Casseb, Gleicilaine A. S.; Ambrosio, Gabriela; Rodrigues, Ana Lucia S.; Kaster, Manuella P.] Univ Fed Santa Catarina, Dept Biochem, BR-88040900 Florianopolis, SC, Brazil.
C3 Universidade Federal de Santa Catarina (UFSC)
RP Kaster, MP (corresponding author), Univ Fed Santa Catarina, Dept Biochem, BR-88040900 Florianopolis, SC, Brazil.
EM manuella.kaster@ufsc.br
RI Rodrigues, Ana Lucia/P-6869-2015; Kaster, Manuella/D-5028-2013
OI Rodrigues, Ana Lucia/0000-0001-6285-8780; Kaster,
   Manuella/0000-0003-0258-6204
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq);
   Coordenacao de Aperfeicoamento de Pessoal de Ensino Superior (CAPES)
FX This study was supported by Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq), and Coordenacao de Aperfeicoamento de
   Pessoal de Ensino Superior (CAPES). MPK and ALSR are CNPq Research
   Fellows.
CR Afzal S, 2014, ALZHEIMERS DEMENT, V10, P296, DOI 10.1016/j.jalz.2013.05.1765
   Afzal S, 2013, J INVEST DERMATOL, V133, P629, DOI 10.1038/jid.2012.395
   Altay H, 2012, ARQ BRAS CARDIOL, V99, P915, DOI 10.1590/S0066-782X2012005000088
   Alvarez JA, 2010, INT J ENDOCRINOL, V2010, DOI 10.1155/2010/351385
   BECK AT, 1988, CLIN PSYCHOL REV, V8, P77, DOI 10.1016/0272-7358(88)90050-5
   Bertone-Johnson ER, 2009, NUTR REV, V67, P481, DOI 10.1111/j.1753-4887.2009.00220.x
   Biaggio A MB., 1977, ARQ BRAS PSICOL APL, V29, P31
   Bikle DD, 2014, CHEM BIOL, V21, P319, DOI 10.1016/j.chembiol.2013.12.016
   Bouillon R, 2008, ENDOCR REV, V29, P726, DOI 10.1210/er.2008-0004
   Caprio M, 2017, EAT WEIGHT DISORD-ST, V22, P27, DOI 10.1007/s40519-016-0312-6
   Chabas JF, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0065034
   Chaowen W, 2016, MEDICINE, V95, P1, DOI [10.1097/MD.0000000000004558, DOI 10.1097/MD.0000000000004558]
   Christakos S, 2007, ANN NY ACAD SCI, V1116, P340, DOI 10.1196/annals.1402.070
   Dicou E, 2009, BRAIN RES REV, V60, P408, DOI 10.1016/j.brainresrev.2009.03.001
   Eelen G, 2004, J BONE MINER RES, V19, P133, DOI 10.1359/JBMR.0301204
   Endler NS, 2001, J ANXIETY DISORD, V15, P231, DOI 10.1016/S0887-6185(01)00060-3
   Fedotova J, 2017, NUTRIENTS, V9, DOI 10.3390/nu9010028
   Féron F, 2005, BRAIN RES BULL, V65, P141, DOI 10.1016/j.brainresbull.2004.12.007
   Gorenstein C, 1996, BRAZ J MED BIOL RES, V29, P453
   Han B, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-24451-7
   Hayes CE, 2003, CELL MOL BIOL, V49, P277
   Hoogendijk WJG, 2008, ARCH GEN PSYCHIAT, V65, P508, DOI 10.1001/archpsyc.65.5.508
   Hua F, 2012, HORM BEHAV, V61, P642, DOI 10.1016/j.yhbeh.2012.02.017
   Jean-Louis G, 2008, J CLIN SLEEP MED, V4, P261
   Jia FY, 2019, NUTR NEUROSCI, V22, P863, DOI 10.1080/1028415X.2018.1458421
   Jiang P, 2013, CELL MOL NEUROBIOL, V33, P309, DOI 10.1007/s10571-012-9902-7
   Jorde R, 2008, J INTERN MED, V264, P599, DOI 10.1111/j.1365-2796.2008.02008.x
   Jorde R, 2006, J NEUROL, V253, P464, DOI 10.1007/s00415-005-0027-5
   Jorde R, 2011, PROG LIPID RES, V50, P303, DOI 10.1016/j.plipres.2011.05.001
   Kalueff AV, 2004, NEUROREPORT, V15, P1271, DOI 10.1097/01.wnr.0000129370.04248.92
   Kampmann U, 2014, METABOLISM, V63, P1115, DOI 10.1016/j.metabol.2014.06.008
   Kayaniyil S, 2010, DIABETES CARE, V33, P1379, DOI 10.2337/dc09-2321
   Khoraminya N, 2013, AUST NZ J PSYCHIAT, V47, P271, DOI 10.1177/0004867412465022
   Kimball SM, 2018, NUTRIENTS, V10, DOI 10.3390/nu10020152
   Maddaloni E, 2018, FRONT HORM RES, V50, P161, DOI 10.1159/000486083
   Maestro B, 2002, CELL BIOCHEM FUNCT, V20, P227, DOI 10.1002/cbf.951
   Maki KC, 2012, METAB SYNDR RELAT D, V10, P363, DOI 10.1089/met.2012.0020
   Manchanda Parmeet Kaur, 2012, Indian J Hum Genet, V18, P274, DOI 10.4103/0971-6866.107975
   Martinez AP, 2012, REV LAT-AM ENFERM, V20, P583, DOI 10.1590/S0104-11692012000300021
   Masuyama R, 2014, J BONE MINER METAB, V32, P1, DOI 10.1007/s00774-013-0508-z
   Milaneschi Y, 2014, MOL PSYCHIATR, V19, P444, DOI 10.1038/mp.2013.36
   Minasyan A, 2007, J STEROID BIOCHEM, V104, P274, DOI 10.1016/j.jsbmb.2007.03.032
   Moritz B, 2017, ACTA NEUROBIOL EXP, V77, P362
   Nair R, 2012, J PHARMACOL PHARMACO, V3, P118, DOI 10.4103/0976-500X.95506
   Nikooyeh B, 2011, AM J CLIN NUTR, V93, P764, DOI 10.3945/ajcn.110.007336
   Patrick PA, 2012, ARCH OPHTHALMOL-CHIC, V130, P756, DOI 10.1001/archophthalmol.2011.2749
   Pittas AG, 2007, DIABETES CARE, V30, P980, DOI 10.2337/dc06-1994
   Reid IR, 2004, DRUG AGING, V21, P7, DOI 10.2165/00002512-200421010-00002
   Reiss S, 1997, J ANXIETY DISORD, V11, P201, DOI 10.1016/S0887-6185(97)00006-6
   Ross AC, 2011, J CLIN ENDOCR METAB, V96, P53, DOI 10.1210/jc.2010-2704
   Schöttker B, 2013, AM J CLIN NUTR, V97, P782, DOI 10.3945/ajcn.112.047712
   SERGEEV IN, 1995, ENDOCRINOLOGY, V136, P2852, DOI 10.1210/en.136.7.2852
   Shaffer JA, 2014, PSYCHOSOM MED, V76, P190, DOI 10.1097/PSY.0000000000000044
   Sheline YI, 2006, BIOL PSYCHIAT, V60, P58, DOI 10.1016/j.biopsych.2005.09.019
   Song YQ, 2013, DIABETES CARE, V36, P1422, DOI 10.2337/dc12-0962
   Spielberger C. D., 1970, MANUAL STATE TRAIT A
   Sung CC, 2012, J BIOMED BIOTECHNOL, DOI 10.1155/2012/634195
   Tang H., 2015, BRAIN INJ PMC, P1
   Tang HL, 2013, HORM BEHAV, V64, P527, DOI 10.1016/j.yhbeh.2013.06.009
   Tsur A, 2013, DIABETES CARE, V36, P1361, DOI 10.2337/dc12-1050
   Upadhyay RK, 2014, INT SCH RES NOTICES, V27, P1
   Vacek JL, 2012, AM J CARDIOL, V109, P359, DOI 10.1016/j.amjcard.2011.09.020
   Van Belle TL, 2013, TRENDS ENDOCRIN MET, V24, P561, DOI 10.1016/j.tem.2013.07.002
   Wang H, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-42
   Wang TJ, 2008, METABOLISM, V63, P1115
   Williams JA, 2016, BMC PREGNANCY CHILDB, V16, DOI 10.1186/s12884-016-0988-7
   Wong KE, 2009, AM J PHYSIOL-ENDOC M, V296, pE820, DOI 10.1152/ajpendo.90763.2008
NR 67
TC 13
Z9 13
U1 0
U2 5
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0885-7490
EI 1573-7365
J9 METAB BRAIN DIS
JI Metab. Brain Dis.
PD APR
PY 2019
VL 34
IS 2
BP 527
EP 535
DI 10.1007/s11011-018-0371-7
PG 9
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA HQ1KK
UT WOS:000462156500014
PM 30604028
DA 2025-06-11
ER

PT J
AU Ghanavati, M
   Rahmani, J
   Clark, CCT
   Hosseinabadi, SM
   Rahimlou, M
AF Ghanavati, Matin
   Rahmani, Jamal
   Clark, Cain C. T.
   Hosseinabadi, Susan Mohammadi
   Rahimlou, Mehran
TI Pistachios and cardiometabolic risk factors: A systematic review and
   meta-analysis of randomized controlled clinical trials
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Review
DE Pistachios; Cardiometabolic risk factors; Meta-analysis
ID CORONARY-HEART-DISEASE; ENDOTHELIAL FUNCTION; NUT CONSUMPTION;
   CARDIOVASCULAR-DISEASE; BLOOD-PRESSURE; POSTPRANDIAL LIPEMIA; METABOLIC
   SYNDROME; OXIDATIVE STRESS; PREDICTING RISKS; LIPID-LEVELS
AB Background: Previous experimental studies have reported that pistachios can elicit positive effects on lipid profile, blood pressure, and inflammation; however, a meta-analysis of the available evidence has yet to be performed.
   Objective: the aim of this study was to conduct systematic review and meta-analysis of the effect of pistachio enriched diets on cardiometabolic risk factors, such as weight, BMI, blood pressure, serum lipids, blood glucose, and inflammatory biomarkers.
   Design: A literature search was carried out for RCTs in medical databases, including PubMed/MEDLINE, Scopus, and Cochrane databases, with no time limitation up to August 2019, and conducted in accordance with the Preferred Reporting Items of Systematic Reviews and Meta-Analysis guidelines.
   Results: 11 RCTs, with 506 participants, that reported the effect of pistachios consumption on cardiometabolic risk factors were included in this systematic review and meta-analysis. Our findings indicated that pistachios consumption significantly reduced FBS (WMD: -3.73, 95 % CI: -6.99, -0.46, I-2 = 99 %), TC/HDL (WMD: -0.46, 95 % CI: -0.76, -0.15, I-2 = 95 %), LDL/HDL (WMD: -0.24, 95 % CI: -0.38, -0.11, I-2  = 96 %), HbA1C (WMD: -0.14, 95 % CI: -0.26, -0.02, I-2  = 60 %), Insulin (WMD: -2.43, 95 % CI: -4.85, -0.001, I-2  = 58 %), SBP (WMD: -3.10, 95 % CI: -5.35, -0.85,I-2  = 63 %), and MDA (WMD: -0.36, 95 % CI: -0.49, -0.23,I-2  = 0%). Importantly, we did not observe adverse effects of pistachios consumption on BMI or blood pressure.
   Conclusion: This systematic review and meta-analysis demonstrates that pistachios consumption can elicit a beneficial effect on some cardiometabolic risk factors. All previous clinical studies are well designed but some points have still remained unclear including the effects of different pistachios dosages on cardio metabolic risk factors and efficacy of pistachios consumption in preventing endothelial dysfunction. Further examination is required to determine the effect of pistachios consumption on further endothelial function risk factors.
C1 [Ghanavati, Matin] Shahid Beheshti Univ Med Sci, Dept & Fac Nutr Sci & Food Technol, Student Res Comm, Tehran, Iran.
   [Ghanavati, Matin; Rahmani, Jamal; Hosseinabadi, Susan Mohammadi] Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, Dept Clin Nutr & Dietet, Tehran, Iran.
   [Clark, Cain C. T.] Coventry Univ, Ctr Intelligent Healthcare, Coventry CV1 5FB, W Midlands, England.
   [Rahimlou, Mehran] Ahvaz Jundishapur Univ Med Sci, Nutr & Metab Dis Res Ctr, Ahvaz, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Coventry University; Ahvaz Jundishapur University of
   Medical Sciences (AJUMS)
RP Rahimlou, M (corresponding author), Ahvaz Jundishapur Univ Med Sci, Nutr & Metab Dis Res Ctr, Ahvaz, Iran.
EM Rahimlum@gmail.com
RI Rahimlou, Mehran/AAL-4902-2021; Clark, Cain/I-4480-2019; Ghanavati,
   Matin/AAD-6617-2022
OI Rahimlou, Mehran/0000-0002-7861-8287; Ghanavati,
   Matin/0000-0001-7447-3845; Clark, Dr. Cain/0000-0002-6610-4617
CR AbuMweis SS, 2014, CAN J CARDIOL, V30, P1225, DOI 10.1016/j.cjca.2014.04.022
   Baer DJ, 2012, BRIT J NUTR, V107, P120, DOI 10.1017/S0007114511002649
   Berry SEE, 2008, AM J CLIN NUTR, V88, P922, DOI 10.1093/ajcn/88.4.922
   Berryman CE, 2013, J NUTR, V143, P788, DOI 10.3945/jn.112.170993
   Borenstein M., 2009, HDB RES SYNTHESIS ME, P221, DOI DOI 10.7758/9781610441384
   Chakraborty SA, 2014, GENETICS, V198, P1015, DOI 10.1534/genetics.114.169508
   Chisholm A, 1998, EUR J CLIN NUTR, V52, P12, DOI 10.1038/sj.ejcn.1600507
   Dreher ML, 2012, NUTR REV, V70, P234, DOI 10.1111/j.1753-4887.2011.00467.x
   Edwards K, 1999, J AM COLL NUTR, V18, P229, DOI 10.1080/07315724.1999.10718856
   Fogacci F, 2019, CRIT REV FOOD SCI, V59, P328, DOI 10.1080/10408398.2017.1368007
   Fraser GE, 2002, J AM COLL NUTR, V21, P275, DOI 10.1080/07315724.2002.10719221
   Gebauer SK, 2008, AM J CLIN NUTR, V88, P651, DOI 10.1093/ajcn/88.3.651
   Gillingham LG, 2011, LIPIDS, V46, P209, DOI 10.1007/s11745-010-3524-y
   Gulati S, 2014, NUTRITION, V30, P192, DOI 10.1016/j.nut.2013.08.005
   Hanhineva K, 2010, INT J MOL SCI, V11, P1365, DOI 10.3390/ijms11041365
   Hernández-Alonso P, 2014, DIABETES CARE, V37, P3098, DOI 10.2337/dc14-1431
   Higgins JPT, 2003, BMJ-BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557
   Higgins Julian P T, 2011, BMJ, V343, pd5928, DOI 10.1136/bmj.d5928
   Josse AR, 2007, METABOLISM, V56, P400, DOI 10.1016/j.metabol.2006.10.024
   Kasliwal RR, 2015, NUTRITION, V31, P678, DOI 10.1016/j.nut.2014.10.019
   Kay CD, 2010, J NUTR, V140, P1093, DOI 10.3945/jn.109.117366
   Kendall CWC, 2014, EUR J CLIN NUTR, V68, P370, DOI 10.1038/ejcn.2013.275
   Kim Y, 2018, NUTRIENTS, V10, DOI 10.3390/nu10121935
   King JG, 2008, J NUTR, V138, p1736S, DOI 10.1093/jn/138.9.1736S
   KINOSIAN B, 1995, J INVEST MED, V43, P443
   KINOSIAN B, 1994, ANN INTERN MED, V121, P641, DOI 10.7326/0003-4819-121-9-199411010-00002
   Kocyigit A, 2006, NUTR METAB CARDIOVAS, V16, P202, DOI 10.1016/j.numecd.2005.08.004
   Li ZP, 2010, J AM COLL NUTR, V29, P198, DOI 10.1080/07315724.2010.10719834
   Lovejoy JC, 2002, AM J CLIN NUTR, V76, P1000, DOI 10.1093/ajcn/76.5.1000
   Luo C, 2014, AM J CLIN NUTR, V100, P256, DOI 10.3945/ajcn.113.076109
   McManus K, 2001, INT J OBESITY, V25, P1503, DOI 10.1038/sj.ijo.0801796
   Mejia SB, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2013-004660
   Mohammadifard N, 2019, NUTR METAB CARDIOVAS
   Mohammadifard N, 2015, AM J CLIN NUTR, V101, P966, DOI 10.3945/ajcn.114.091595
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Natarajan S, 2003, AM J PREV MED, V25, P50, DOI 10.1016/S0749-3797(03)00092-8
   Neale EP, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2017-016863
   Ong HG, 2017, FOOD SECUR, V9, P11, DOI 10.1007/s12571-016-0630-6
   Parham Mahmoud, 2014, Rev Diabet Stud, V11, P190, DOI 10.1900/RDS.2014.11.190
   Paterniti I, 2017, NUTRIENTS, V9, DOI 10.3390/nu9080915
   Sabaté J, 2010, ARCH INTERN MED, V170, P821, DOI 10.1001/archinternmed.2010.79
   Salas-Salvadó J, 2006, BRIT J NUTR, V96, pS45, DOI 10.1017/BJN20061863
   Salem Z, 2014, J OCCUP HLTH EPIDEMI, V3, P171
   Sari I, 2010, NUTRITION, V26, P399, DOI 10.1016/j.nut.2009.05.023
   Sauder KA, 2015, METABOLISM, V64, P1521, DOI 10.1016/j.metabol.2015.07.021
   Sauder KA, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.114.000873
   Segura R, 2006, BRIT J NUTR, V96, pS36, DOI 10.1017/BJN20061862
   Stuetz W, 2017, FOOD CHEM, V221, P222, DOI 10.1016/j.foodchem.2016.10.065
   Thomas H, 2018, GLOB HEART, V13, P143, DOI 10.1016/j.gheart.2018.09.511
   Wang JG, 2005, HYPERTENSION, V45, P907, DOI 10.1161/01.HYP.0000165020.14745.79
   Wang X, 2012, NUTR J, V11, DOI 10.1186/1475-2891-11-20
   West SG, 2012, HYPERTENSION, V60, P58, DOI 10.1161/HYPERTENSIONAHA.111.182147
   Wien M, 2010, J AM COLL NUTR, V29, P189, DOI 10.1080/07315724.2010.10719833
NR 53
TC 45
Z9 46
U1 1
U2 9
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD AUG
PY 2020
VL 52
AR 102513
DI 10.1016/j.ctim.2020.102513
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA OA1IW
UT WOS:000577549300061
PM 32951758
OA Green Published
DA 2025-06-11
ER

PT J
AU Vetter, ML
   Wadden, TA
   Lavenberg, J
   Moore, RH
   Volger, S
   Perez, JL
   Sarwer, DB
   Tsai, AG
AF Vetter, M. L.
   Wadden, T. A.
   Lavenberg, J.
   Moore, R. H.
   Volger, S.
   Perez, J. L.
   Sarwer, D. B.
   Tsai, A. G.
TI Relation of health-related quality of life to metabolic syndrome,
   obesity, depression and comorbid illnesses
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
DE quality of life; metabolic syndrome
ID BODY-MASS INDEX; DISEASE; MORTALITY; IMPACT; ASSOCIATION; VALIDATION;
   OVERWEIGHT; SYMPTOMS; SF-12
AB Background: Metabolic syndrome has been associated with impaired health-related quality of life (HRQoL) in several studies. Many studies used only one HRQoL measure and failed to adjust for important confounding variables, including obesity, depression and comorbid conditions.
   Objective: To investigate the relationship between metabolic syndrome and HRQoL using multiple measures. We also sought to determine whether increasing body mass index or diabetes status further modified this relationship.
   Methods: This cross-sectional study included 390 obese participants with elevated waist circumference and at least one other criterion for metabolic syndrome. Of these 390 participants, 269 had metabolic syndrome (that is, they met 3 out of the 5 criteria specified by the NCEP (National Cholesterol Education Program)) and 121 did not. Participants were enrolled in a primary care-based weight-reduction trial. HRQoL was assessed using two generic instruments, the Medical Outcomes Study Short-Form 12 and the EuroQol-5D, as well as an obesity-specific measure, the Impact of Weight on Quality of Life. Differences in HRQoL were compared among participants with and without metabolic syndrome. Multivariable linear regression was used to determine how HRQoL varied according to metabolic syndrome status, and whether factors including weight, depression and burden of comorbid disease modified this relationship.
   Results: Metabolic syndrome was not associated with HRQoL as assessed by any of the measures. In univariable analysis, depression, disease burden and employment status were significantly associated with worse HRQoL on all instruments. In multivariable models, only depression remained significantly associated with reduced HRQoL on all measures. Increasing obesity and diabetes status did not modify the relationship between metabolic syndrome and HRQoL.
   Conclusion: In contrast to previous studies, metabolic syndrome was not associated with impaired HRQoL as assessed by multiple measures. This suggests that metabolic syndrome in itself is not associated with decreased HRQoL, but other factors such as obesity, depression and greater disease burden may significantly influence the quality of life in this population. International Journal of Obesity (2011) 35, 1087-1094; doi:10.1038/ijo.2010.230; published online 2 November 2010
C1 [Vetter, M. L.; Wadden, T. A.; Lavenberg, J.; Moore, R. H.; Volger, S.; Perez, J. L.; Sarwer, D. B.] Univ Penn, Ctr Weight & Eating Disorders, Dept Psychiat, Sch Med, Philadelphia, PA 19104 USA.
   [Vetter, M. L.] Univ Penn, Div Endocrinol Diabet & Metab, Dept Med, Sch Med, Philadelphia, PA 19104 USA.
   [Moore, R. H.] Univ Penn, Dept Epidemiol & Biostat, Ctr Clin Epidemiol & Biostat, Sch Med, Philadelphia, PA 19104 USA.
   [Tsai, A. G.] Univ Colorado, Dept Med, Div Gen Internal Med, Denver, CO USA.
C3 University of Pennsylvania; University of Pennsylvania; University of
   Pennsylvania; University of Colorado System; University of Colorado
   Anschutz Medical Campus; University of Colorado Denver
RP Vetter, ML (corresponding author), Univ Penn, Ctr Weight & Eating Disorders, Dept Psychiat, Sch Med, 3535 Market St,Suite 3108, Philadelphia, PA 19104 USA.
EM marion.vetter@uphs.upenn.edu
RI Cobden, David/AGL-5940-2022; Moore, Richard/E-9653-2010
OI volger, sheri/0000-0002-1689-1173; Wadden, Thomas/0000-0002-0438-4609
FU National Heart, Lung and Blood Institute [U01HL087072-04]; National
   Institute of Diabetes and Digestive and Kidney Diseases
   [5K24DK065018-07]
FX We thank Christopher Vinnard, MD, MPH, MSCE for his editorial
   assistance. This study was supported by grants from the National Heart,
   Lung and Blood Institute (U01HL087072-04) and from the National
   Institute of Diabetes and Digestive and Kidney Diseases
   (5K24DK065018-07).
CR [Anonymous], 2009, National health statistics reports
   [Anonymous], NIH PUBL
   Boini S, 2006, INT J CARDIOL, V113, P215, DOI 10.1016/j.ijcard.2005.11.016
   Carpenter KM, 2000, AM J PUBLIC HEALTH, V90, P251, DOI 10.2105/AJPH.90.2.251
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Coffey JT, 2002, DIABETES CARE, V25, P2238, DOI 10.2337/diacare.25.12.2238
   Dolan P, 1997, MED CARE, V35, P1095, DOI 10.1097/00005650-199711000-00002
   Fabricatore AN, 2005, OBES SURG, V15, P304, DOI 10.1381/0960892053576578
   FerroLuzzi A, 1995, WHO TECH REP SER, V854, P1
   Ford ES, 2008, ANN EPIDEMIOL, V18, P165, DOI 10.1016/j.annepidem.2007.10.009
   Ford ES, 2001, OBES RES, V9, P21, DOI 10.1038/oby.2001.4
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   Forhan M, 2010, OBES REV, V11, P222, DOI 10.1111/j.1467-789X.2009.00612.x
   Fortin Martin, 2004, Health Qual Life Outcomes, V2, P51, DOI 10.1186/1477-7525-2-51
   Frisman GH, 2009, EUR J CARDIOVASC NUR, V8, P207, DOI 10.1016/j.ejcnurse.2009.01.004
   Gallegos-Carrillo K, 2009, J PSYCHOSOM RES, V66, P127, DOI 10.1016/j.jpsychores.2008.07.007
   Gandek B, 1998, J CLIN EPIDEMIOL, V51, P1171, DOI 10.1016/S0895-4356(98)00109-7
   Groll DL, 2005, J CLIN EPIDEMIOL, V58, P595, DOI 10.1016/j.jclinepi.2004.10.018
   Han JH, 2009, INT J CLIN PRACT, V63, P735, DOI 10.1111/j.1742-1241.2009.02021.x
   HESHKA S, 2003, JAMA-J AM MED ASSOC, V298, P1982
   JACOBSON AM, 1994, DIABETES CARE, V17, P267, DOI 10.2337/diacare.17.4.267
   Jia HM, 2005, J PUBLIC HEALTH-UK, V27, P156, DOI 10.1093/pubmed/fdi025
   Katz DA, 2000, J GEN INTERN MED, V15, P789, DOI 10.1046/j.1525-1497.2000.90906.x
   Kleefstra N, 2008, DIABETES CARE, V31, P932, DOI 10.2337/dc07-2072
   Kolotkin RL, 2003, DIABETES RES CLIN PR, V61, P125, DOI 10.1016/S0168-8227(03)00113-X
   Kolotkin RL, 2001, OBES RES, V9, P102, DOI 10.1038/oby.2001.13
   Kolotkin RL, 2009, HEALTH QUAL LIFE OUT, V7, DOI 10.1186/1477-7525-7-53
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Kroenke K, 2009, J AFFECT DISORDERS, V114, P163, DOI 10.1016/j.jad.2008.06.026
   Mathias SD, 1997, QUAL LIFE RES, V6, P311, DOI 10.1023/A:1018475108460
   Mena-Martin FJ, 2003, J HYPERTENS, V21, P1283, DOI 10.1097/00004872-200307000-00015
   Miettola J, 2008, QUAL LIFE RES, V17, P1055, DOI 10.1007/s11136-008-9386-6
   Mond JM, 2009, OBESITY, V17, P1627, DOI 10.1038/oby.2009.27
   Must A, 1999, JAMA-J AM MED ASSOC, V282, P1523, DOI 10.1001/jama.282.16.1523
   Pressler SJ, 2011, AM J CRIT CARE, V20, P146, DOI 10.4037/ajcc2010931
   Roberts RE, 2003, INT J OBESITY, V27, P514, DOI 10.1038/sj.ijo.0802204
   Rothrock NE, 2010, J CLIN EPIDEMIOL, V63, P1195, DOI 10.1016/j.jclinepi.2010.04.012
   Sach TH, 2007, INT J OBESITY, V31, P189, DOI 10.1038/sj.ijo.0803365
   Schenkeveld L, 2010, AM HEART J, V159, P471, DOI 10.1016/j.ahj.2009.12.012
   Schlotz W, 2007, QUAL LIFE RES, V16, P429, DOI 10.1007/s11136-006-9129-5
   *SF COMM, SF 12 EV SHORT HLTH
   Simon GE, 2006, ARCH GEN PSYCHIAT, V63, P824, DOI 10.1001/archpsyc.63.7.824
   Soltoft F, 2009, QUAL LIFE RES, V18, P1293, DOI 10.1007/s11136-009-9541-8
   Tsai AG, 2008, OBESITY, V16, P59, DOI 10.1038/oby.2007.8
   UK Prospective Diabetes Study Grp, 1999, DIABETES CARE, V22, P1125
   Unsar S, 2007, J CARDIOVASC NURS, V22, P501, DOI 10.1097/01.JCN.0000297382.91131.8d
   Ware JE, 1996, MED CARE, V34, P220, DOI 10.1097/00005650-199603000-00003
   Wee CC, 2008, HEALTH QUAL LIFE OUT, V6, DOI 10.1186/1477-7525-6-11
   Yancy WS, 2002, OBES RES, V10, P1057, DOI 10.1038/oby.2002.143
NR 49
TC 52
Z9 65
U1 0
U2 10
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD AUG
PY 2011
VL 35
IS 8
BP 1087
EP 1094
DI 10.1038/ijo.2010.230
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 806DA
UT WOS:000293784100010
PM 21042326
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Labenz, C
   Huber, Y
   Michel, M
   Nagel, M
   Galle, PR
   Kostev, K
   Schattenberg, JM
AF Labenz, Christian
   Huber, Yvonne
   Michel, Maurice
   Nagel, Michael
   Galle, Peter R.
   Kostev, Karel
   Schattenberg, Joern M.
TI Nonalcoholic Fatty Liver Disease Increases the Risk of Anxiety and
   Depression
SO HEPATOLOGY COMMUNICATIONS
LA English
DT Article
ID METABOLIC SYNDROME; STEATOHEPATITIS; ADULTS; ASSOCIATION; OBESITY;
   REPRESENTATIVENESS; INFLAMMATION; OVERWEIGHT; HEALTH
AB Nonalcoholic fatty liver disease (NAFLD), depression, and anxiety disorders are frequent diseases, and data on mutual influence are inconsistent. The aim of this study was to explore the incidence of depression and anxiety in a large primary care cohort in Germany and to study the impact of NAFLD over a 10-year time frame. Patients with NAFLD diagnosed between 2010 and 2015 were matched to a cohort without NAFLD controlling for age, sex, physician, index year, and Charlson comorbidity index. The primary outcome of the study was the incidence of depression, anxiety, and first prescription of antidepressant drugs. We compared 19,871 patients with NAFLD to 19,871 matched controls. Within 10 years of the index date, 21.2% of patients with NAFLD and 18.2% of controls were diagnosed with depression (P < 0.001). On regression analysis, the hazard ratio (HR) for incidence of depression was 1.21 (P < 0.001). This association was similar for the endpoint of the first prescription of antidepressant drugs (HR, 1.21;P < 0.001). Anxiety disorders were diagnosed in 7.9% of patients with NAFLD and 6.5% of controls during the observation time (P = 0.003). The HR for incidence of anxiety was 1.23 (P < 0.001). This association remained significant in women (P < 0.001), while there was only a trend in men (HR, 1.15; 95% confidence interval, 0.99-1.34;P < 0.067). The risk of developing anxiety disorders was higher in younger patients.Conclusion:NAFLD constitutes an independent risk factor for emerging depression and anxiety even after controlling for confounding comorbidities.
C1 [Labenz, Christian; Huber, Yvonne; Michel, Maurice; Nagel, Michael; Galle, Peter R.; Schattenberg, Joern M.] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Med 1, Mainz, Germany.
   [Labenz, Christian; Huber, Yvonne; Michel, Maurice; Nagel, Michael; Galle, Peter R.; Schattenberg, Joern M.] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Metab Liver Res Program, Mainz, Germany.
   [Kostev, Karel] IQVIA, Epidemiol, Frankfurt, Germany.
C3 Johannes Gutenberg University of Mainz; Johannes Gutenberg University of
   Mainz; IQVIA
RP Schattenberg, JM (corresponding author), Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Med 1, Metab Liver Res Program, Langenbeckstr 1, D-55131 Mainz, Germany.
EM joern.schattenberg@unimedizin-mainz.de
RI Schattenberg, Jörn/C-1301-2013; Galle, Peter/ABE-2872-2021; Kostev,
   Karel/S-4755-2019
OI Kostev, Karel/0000-0002-2124-7227; Galle, Peter
   Robert/0000-0001-8294-0992; Schattenberg, Jorn M./0000-0002-4224-4703
FU University Medical Center Mainz
FX Supported in part by the University Medical Center Mainz (intramural
   funds to J.M.S.).
CR Alexander M, 2019, BMC MED, V17, DOI 10.1186/s12916-019-1321-x
   Anderson RJ, 2002, INT J PSYCHIAT MED, V32, P235, DOI 10.2190/KLGD-4H8D-4RYL-TWQ8
   [Anonymous], 2019, DIABETES CARE, V42, pS4, DOI 10.2337/dc19-Srev01
   Becher H, 2009, INT J CLIN PHARM TH, V47, P617
   Bica T, 2017, J NURS SCHOLARSHIP, V49, P389, DOI 10.1111/jnu.12303
   Bodenlos JS, 2011, J PSYCHOSOM RES, V71, P319, DOI 10.1016/j.jpsychores.2011.03.004
   Chan KL, 2019, PHYSIOLOGY, V34, P123, DOI 10.1152/physiol.00047.2018
   EASL, 2016, OBESITY FACTS, V9, P65, DOI [10.1159/000443344, 10.1007/s00125-016-3902-y, 10.1016/j.jhep.2015.11.004]
   Elhwuegi AS, 2004, PROG NEURO-PSYCHOPH, V28, P435, DOI 10.1016/j.pnpbp.2003.11.018
   Elwing JE, 2006, PSYCHOSOM MED, V68, P563, DOI 10.1097/01.psy.0000221276.17823.df
   Estes C, 2018, J HEPATOL, V69, P896, DOI 10.1016/j.jhep.2018.05.036
   GBD 2015 Disease and Injury Incidence and Prevalence Collaborators, 2016, Lancet, V388, P1545, DOI 10.1016/S0140-6736(16)31678-6
   Gehrke N, 2020, GASTROENTEROLOGY, V158, P1929, DOI 10.1053/j.gastro.2020.02.020
   Herrera-Marquez R, 2011, METAB BRAIN DIS, V26, P29, DOI 10.1007/s11011-010-9229-3
   Huang XQ, 2017, FRONT MOL NEUROSCI, V10, DOI 10.3389/fnmol.2017.00134
   Huber Y, 2019, CLIN GASTROENTEROL H, V17, P2085, DOI 10.1016/j.cgh.2018.12.016
   Kim D, 2019, ALIMENT PHARM THER, V50, P590, DOI 10.1111/apt.15395
   Labenz C, 2019, HEPATOL COMMUN, V3, P1472, DOI 10.1002/hep4.1428
   Labenz C, 2018, ALIMENT PHARM THER, V48, P1109, DOI 10.1111/apt.14976
   Lee K, 2013, PSYCHOSOMATICS, V54, P52, DOI 10.1016/j.psym.2012.09.005
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Marjot T, 2020, ENDOCR REV, V41, P66, DOI 10.1210/endrev/bnz009
   Mensink GBM, 2013, BUNDESGESUNDHEITSBLA, V56, P786, DOI 10.1007/s00103-012-1656-3
   Muldoon MF, 2004, J CLIN ENDOCR METAB, V89, P266, DOI 10.1210/jc.2003-031295
   Park SJ, 2016, J AFFECT DISORDERS, V205, P393, DOI 10.1016/j.jad.2016.08.022
   Quan HD, 2005, MED CARE, V43, P1130, DOI 10.1097/01.mlr.0000182534.19832.83
   Rathmann W, 2018, INT J CLIN PHARM TH, V56, P459, DOI 10.5414/CP203320
   Schattenberg JM, 2019, BMC MED, V17, DOI 10.1186/s12916-019-1357-y
   Schattenberg JM, 2011, CURR OPIN LIPIDOL, V22, P479, DOI 10.1097/MOL.0b013e32834c7cfc
   Schuppan D, 2013, J GASTROEN HEPATOL, V28, P68, DOI 10.1111/jgh.12212
   Silic A, 2012, J AFFECT DISORDERS, V141, P72, DOI 10.1016/j.jad.2012.02.019
   Tomeno W, 2015, J GASTROEN HEPATOL, V30, P1009, DOI 10.1111/jgh.12897
   Weinstein AA, 2011, PSYCHOSOMATICS, V52, P127, DOI 10.1016/j.psym.2010.12.019
   Weinstein G, 2018, JAMA NEUROL, V75, P97, DOI 10.1001/jamaneurol.2017.3229
   Wong RJ, 2015, GASTROENTEROLOGY, V148, P547, DOI 10.1053/j.gastro.2014.11.039
   Younossi Z, 2019, HEPATOLOGY, V69, P2672, DOI 10.1002/hep.30251
   Younossi Z, 2018, NAT REV GASTRO HEPAT, V15, P11, DOI 10.1038/nrgastro.2017.109
   Younossi ZM, 2019, LANCET, V394, P2184, DOI 10.1016/S0140-6736(19)33041-7
   Younossi ZM, 2019, J HEPATOL, V70, P531, DOI 10.1016/j.jhep.2018.10.033
   Youssef NA, 2013, LIVER INT, V33, P1062, DOI 10.1111/liv.12165
NR 40
TC 86
Z9 86
U1 1
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
EI 2471-254X
J9 HEPATOL COMMUN
JI Hepatol. Commun.
PD SEP
PY 2020
VL 4
IS 9
BP 1293
EP 1301
DI 10.1002/hep4.1541
EA JUN 2020
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA NO7ID
UT WOS:000543546900001
PM 32923833
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Murphy, KJ
   Parletta, N
AF Murphy, Karen J.
   Parletta, Natalie
TI Implementing a Mediterranean-Style Diet Outside the Mediterranean Region
SO CURRENT ATHEROSCLEROSIS REPORTS
LA English
DT Review
DE Mediterranean diet; MedDiet; MedLey; HELFIMED; Blue zones
ID RANDOMIZED CONTROLLED-TRIAL; CARDIOVASCULAR RISK; METABOLIC SYNDROME;
   MAJOR DEPRESSION; INTERVENTION; ADULTS; WOMEN; PROTOCOL; DISEASE;
   PATTERN
AB Purpose of Review Populations surrounding the Mediterranean basin have traditionally reaped health benefits from a Mediterranean diet (MedDiet), which may benefit Westernized countries plagued by chronic disease. But is it feasible to implement beyond the Mediterranean? To answer this question, we present evidence from randomized controlled trials that achieved high dietary compliance rates with subsequent physical and mental health benefits.
   Recent Findings In the 1960s, the Seven Countries Study identified dietary qualities of Mediterranean populations associated with healthy aging and longevity. The PREDIMED study confirmed reductions in CVD-related mortality with a MedDiet; a meta-analysis in over 4.7 million people showed reduced mortality, CVD-related mortality, and reduced risk of Parkinson's and Alzheimer's disease. Continually emerging research supports the MedDiet's benefits for chronic diseases including metabolic syndrome, cancers, liver disease, type 2 diabetes, depression, and anxiety.
   Summary We summarize components of studies outside the Mediterranean that achieved high compliance to a Med-style diet: dietitian led, dietary education, goal setting, mindfulness; recipe books, meal plans, and food checklists; food hampers; regular contact between volunteers and staff through regular cooking classes; clinic visits; and recipes that are simple, palatable, and affordable. The next step is testing the MedDiet's feasibility in the community. Potential obstacles include access to dietetic/health care professionals, high meat intake, pervasive processed foods, and fast food outlets. For Western countries to promote a Med-style diet, collective support from government, key stakeholders and policy makers, food industry, retailers, and health professionals is needed to ensure the healthiest choice is the easiest choice.
C1 [Murphy, Karen J.; Parletta, Natalie] Univ South Australia, Sch Pharm & Med Sci, GPO Box 2471, Adelaide, SA 5000, Australia.
C3 University of South Australia
RP Murphy, KJ (corresponding author), Univ South Australia, Sch Pharm & Med Sci, GPO Box 2471, Adelaide, SA 5000, Australia.
EM karen.murphy@unisa.edu.au
RI Murphy, Karen/B-5163-2009; Parletta, Natalie/A-7880-2008
OI Murphy, Karen/0000-0002-2589-1319
CR [Anonymous], AM J CLIN NUTR
   [Anonymous], 2015, Lancet
   [Anonymous], HIST OLIVE OIL EXPLO
   [Anonymous], EUROPEAN FOOD SAFETY
   [Anonymous], BMC PSYCHIAT
   [Anonymous], OLDER AUSTR CAN ACHI
   [Anonymous], 6401 0 CONS PRIC IND
   [Anonymous], AGR OUTL MEAT CONS
   [Anonymous], AUSTR J PRIMARY HLTH
   [Anonymous], 2015, Dietary guidelines for Americans 2015-2020
   [Anonymous], 2015, BMC Nutr
   [Anonymous], RESULTS MEDLEY STUDY
   [Anonymous], 2013, BBC News
   Australian Bureau of Statistics, 2016, AUSTR HLTH SURV CONS
   Bach-Faig A, 2011, PUBLIC HEALTH NUTR, V14, P2274, DOI 10.1017/S1368980011002515
   Bogomolova S, 2018, HEALTH PROMOT INT, V33, P71, DOI 10.1093/heapro/daw055
   Davis C, 2015, NUTRIENTS, V7, P9139, DOI 10.3390/nu7115459
   Davis CR, 2017, J NUTR, V147, P1348, DOI 10.3945/jn.117.248419
   de Lorgeril M, 1999, CIRCULATION, V99, P779, DOI 10.1161/01.CIR.99.6.779
   Estruch R, 2006, ANN INTERN MED, V145, P1, DOI 10.7326/0003-4819-145-1-200607040-00004
   Gu YA, 2010, J ALZHEIMERS DIS, V22, P483, DOI 10.3233/JAD-2010-100897
   Hardman RJ, 2015, NUTR J, V14, DOI 10.1186/s12937-015-0042-z
   Hodge AM, 2011, NUTR METAB CARDIOVAS, V21, P733, DOI 10.1016/j.numecd.2010.10.014
   Itsiopoulos C, 2011, NUTR METAB CARDIOVAS, V21, P740, DOI 10.1016/j.numecd.2010.03.005
   Itsiopoulos C., 2015, MEDITERRANEAN DIET
   Jacka FN, 2017, BMC MED, V15, DOI 10.1186/s12916-017-0791-y
   Kafatos A, 2000, J AM DIET ASSOC, V100, P1487, DOI 10.1016/S0002-8223(00)00416-8
   Kastorini CM, 2011, J AM COLL CARDIOL, V57, P1299, DOI 10.1016/j.jacc.2010.09.073
   KEYS A, 1986, AM J EPIDEMIOL, V124, P903, DOI 10.1093/oxfordjournals.aje.a114480
   Knight A, 2016, NUTRIENTS, V8, DOI 10.3390/nu8090579
   Knight A, 2015, BMC GERIATR, V15, DOI 10.1186/s12877-015-0054-8
   Lee J, 2015, NUTRITION, V31, P647, DOI 10.1016/j.nut.2014.10.008
   Opie RS, 2018, NUTR NEUROSCI, V21, P487, DOI [10.1080/1028415X.2017.1312841, 10.1080/1028415x.2017.1312841]
   Papamiltiadous ES, 2016, BMC GASTROENTEROL, V16, DOI 10.1186/s12876-016-0426-3
   Parletta N, 2017, Nutr. Neurosci., P1
   Psaltopoulou T, 2013, ANN NEUROL, V74, P580, DOI 10.1002/ana.23944
   Rienks J, 2013, EUR J CLIN NUTR, V67, P75, DOI 10.1038/ejcn.2012.193
   Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012
   Salas-Salvadó J, 2008, ARCH INTERN MED, V168, P2449, DOI 10.1001/archinte.168.22.2449
   Scarmeas N, 2009, JAMA-J AM MED ASSOC, V302, P627, DOI 10.1001/jama.2009.1144
   Scarmeas N, 2006, ANN NEUROL, V59, P912, DOI 10.1002/ana.20854
   Scarmeas N, 2006, ARCH NEUROL-CHICAGO, V63, P1709, DOI 10.1001/archneur.63.12.noc60109
   Schwarzfuchs D, 2012, NEW ENGL J MED, V367, P1373, DOI 10.1056/NEJMc1204792
   Shai I, 2008, NEW ENGL J MED, V359, P229, DOI 10.1056/NEJMoa0708681
   Sofi F, 2014, PUBLIC HEALTH NUTR, V17, P2769, DOI 10.1017/S1368980013003169
   Sofi F, 2008, BMJ-BRIT MED J, V337, DOI 10.1136/bmj.a1344
   Svedbom A, 2013, ARCH OSTEOPOROS, V8, DOI 10.1007/s11657-013-0137-0
   Toledo E, 2015, JAMA INTERN MED, V175, P1752, DOI 10.1001/jamainternmed.2015.4838
   Trichopoulou A, 2006, TRENDS FOOD SCI TECH, V17, P498, DOI 10.1016/j.tifs.2006.03.005
   Valls-Pedret C, 2015, JAMA INTERN MED, V175, P1094, DOI 10.1001/jamainternmed.2015.1668
   Wade AT, 2017, NUTR J, V16, DOI 10.1186/s12937-017-0306-x
   Wade AT, 2017, NUTRIENTS, V9, DOI 10.3390/nu9020145
   Zarnowiecki D., 2016, BMC Nutrition, V2, P1, DOI DOI 10.1186/S40795-016-0095-1
NR 53
TC 47
Z9 52
U1 1
U2 69
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1523-3804
EI 1534-6242
J9 CURR ATHEROSCLER REP
JI Curr. Atheroscleros. Rep.
PD JUN
PY 2018
VL 20
IS 6
AR 28
DI 10.1007/s11883-018-0732-z
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GG0TM
UT WOS:000432392000003
PM 29728772
DA 2025-06-11
ER

PT J
AU Matsuda, R
   Kohno, T
   Kohsaka, S
   Fukuoka, R
   Maekawa, Y
   Sano, M
   Takatsuki, S
   Fukuda, K
AF Matsuda, Risa
   Kohno, Takashi
   Kohsaka, Shun
   Fukuoka, Ryoma
   Maekawa, Yuichiro
   Sano, Motoaki
   Takatsuki, Seiji
   Fukuda, Keiichi
TI The prevalence of poor sleep quality and its association with depression
   and anxiety scores in patients admitted for cardiovascular disease: A
   cross-sectional designed study
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Sleep disorders; Depression; Anxiety; Cardiovascular diseases
ID ACUTE MYOCARDIAL-INFARCTION; CORONARY-HEART-DISEASE; CLINICAL
   CARDIOLOGY; ATRIAL-FIBRILLATION; METABOLIC SYNDROME; CHRONIC INSOMNIA;
   RISK-FACTORS; POPULATION; SYMPTOMS; OUTCOMES
AB Background: Poor sleep quality contributes to the development of various cardiovascular conditions. However, its real-world prevalence among cardiovascular inpatients and association with psychological disturbance is unknown. This study aimed to assess the prevalence of poor sleep quality and its association with depression and anxiety in cardiovascular patients, and explored whether sex and cardiovascular comorbidities modified these associations.
   Methods: A total of 1071 patients hospitalized for a broad spectrum of cardiovascular diseases at a single university hospital were assessed (790 men, mean age 64 +/- 14 years). We assessed sleep quality during their index hospitalization period using the Pittsburgh Sleep Quality Index (PSQI); poor sleep quality was defined as PSQI > 5. Depression and anxiety were assessed with the Hospital Anxiety and Depression Scale (HADS).
   Results: The median PSQI score was 5.0 [3.0 - 7.0], and 461 inpatients (43%) had poor sleep quality. Multivariate regression analysis adjusting for patient background, medical risk factors, and laboratory data revealed that poor sleep quality was associated with higher HADS subscores for depression (HADS-depression; odds ratio [OR]: 1.09, 95% confidence interval [CI]: 1.03 - 1.15) and anxiety (HADS-anxiety; OR: 1.17, 95% CI: 1.11 - 1.24). Poor sleep quality was associated with markedly higher HADS-depression among women than men (p value for interaction: 0.008). The association between poor sleep quality and HADS-anxiety was more significant among patients without coronary artery diseases (p value for interaction: 0.017).
   Conclusions: Poor sleep quality was highly prevalent and associated with depression and anxiety in cardiovascular patients. These associations may be modified by sex and the presence of coronary artery diseases. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Matsuda, Risa; Kohno, Takashi; Kohsaka, Shun; Fukuoka, Ryoma; Maekawa, Yuichiro; Sano, Motoaki; Takatsuki, Seiji; Fukuda, Keiichi] Keio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan.
C3 Keio University
RP Kohno, T (corresponding author), Keio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan.
EM kohno.a2@keio.jp
RI takatsuki, seiji/M-1862-2013; Sano, Motoaki/L-3405-2013; Kohsaka,
   Shun/L-8695-2013; Fukuda, Keiichi/L-3777-2013
CR Barefoot JC, 1996, CIRCULATION, V93, P1976, DOI 10.1161/01.CIR.93.11.1976
   Bjelland I, 2002, J PSYCHOSOM RES, V52, P69, DOI 10.1016/S0022-3999(01)00296-3
   Bruno RM, 2013, SLEEP MED, V14, P1157, DOI 10.1016/j.sleep.2013.04.020
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1016/0165-1781(89)90047-4
   Cappuccio FP, 2011, EUR HEART J, V32, P1484, DOI 10.1093/eurheartj/ehr007
   Doi Y, 2000, PSYCHIAT RES, V97, P165, DOI 10.1016/S0165-1781(00)00232-8
   Frasure-Smith N, 2009, CIRCULATION, V120, P134, DOI 10.1161/CIRCULATIONAHA.109.851675
   Guo L, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2014-005517
   Hare DL, 2014, EUR HEART J, V35, P1365, DOI 10.1093/eurheartj/eht462
   Hoevenaar-Blom MP, 2011, SLEEP, V34, P1487, DOI 10.5665/sleep.1382
   Jaussent I, 2011, SLEEP, V34, P1103, DOI 10.5665/SLEEP.1170
   Jennings JR, 2007, SLEEP, V30, P219, DOI 10.1093/sleep/30.2.219
   Kasai T, 2012, CIRCULATION, V126, P1495, DOI 10.1161/CIRCULATIONAHA.111.070813
   Kimura T, 2015, CAN J CARDIOL, V31, P846, DOI 10.1016/j.cjca.2014.12.032
   Laugsand LE, 2014, EUR HEART J, V35, P1382, DOI 10.1093/eurheartj/eht019
   Laugsand LE, 2011, CIRCULATION, V124, P2073, DOI 10.1161/CIRCULATIONAHA.111.025858
   Lichtman JH, 2008, CIRCULATION, V118, P1768, DOI 10.1161/CIRCULATIONAHA.108.190769
   Macey PM, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010211
   Matsuo S, 2009, AM J KIDNEY DIS, V53, P982, DOI 10.1053/j.ajkd.2008.12.034
   Michal M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0104324
   Morin CM, 2012, LANCET, V379, P1129, DOI 10.1016/S0140-6736(11)60750-2
   Muraki I, 2010, DIABETOLOGIA, V53, P481, DOI 10.1007/s00125-009-1616-0
   Nair N, 2012, AM J CARDIOL, V109, P768, DOI 10.1016/j.amjcard.2011.10.039
   Neckelmann D, 2007, SLEEP, V30, P873, DOI 10.1093/sleep/30.7.873
   Nicholson A, 2006, EUR HEART J, V27, P2763, DOI 10.1093/eurheartj/ehl338
   Okubo N, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-562
   Peppard PE, 2006, ARCH INTERN MED, V166, P1709, DOI 10.1001/archinte.166.16.1709
   Redline S, 2011, CIRCULATION, V124, P2049, DOI 10.1161/CIRCULATIONAHA.111.062190
   Rutledge T, 2006, J AM COLL CARDIOL, V48, P1527, DOI 10.1016/j.jacc.2006.06.055
   Somers VK, 2008, CIRCULATION, V118, P1080, DOI [10.1161/CIRCULATIONAHA.107.189420, 10.1161/CIRCULATIONAHA.107.189375]
   Tanigawa T, 2004, JAMA-J AM MED ASSOC, V292, P923, DOI 10.1001/jama.292.8.923-b
   Watkins LL, 2013, J AM HEART ASSOC, V2, DOI 10.1161/JAHA.112.000068
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 33
TC 45
Z9 52
U1 2
U2 22
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD FEB 1
PY 2017
VL 228
BP 977
EP 982
DI 10.1016/j.ijcard.2016.11.091
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA EJ7NJ
UT WOS:000393408600154
PM 27915216
DA 2025-06-11
ER

PT J
AU Cruz, MME
   Gozal, D
   Salles, C
   Rocha, I
   Ettlin, D
AF Meira E Cruz, Miguel
   Gozal, David
   Salles, Cristina
   Rocha, Isabel
   Ettlin, Dominik
TI Interactions between Insomnia, Sleep Disordered Breathing and
   Cardiometabolic Risk in Patients Complaining of Pain in the Orofacial
   Region
SO ACTA MEDICA PORTUGUESA
LA English
DT Article
DE Cardiometabolic Risk Factors; Facial Pain; Sleep Apnea Syndromes; Sleep
   Initiation and Maintenance Disorders
ID VALIDATION
AB The existence of intersected pathways between the mechanisms of insomnia, sleep-disordered breathing and persistent/chronic pain has been documented. Such concurrence will eventually contribute to a higher burden of cardiometabolic diseases, a main cause of death worldwide. The aim of this study was to evaluate the interactions between insomnia, sleep-disordered breathing, cardiometabolic risk, and psychosocial stress in patients seeking care at an orofacial pain clinic. Anonymized data of 1236 patients seeking care at the orofacial pain unit of the University of Zurich were analysed. Prevalence data was estimated for insomnia, sleep disordered breathing/sleep apnea and increased risk of a combination of insomnia and sleep disordered breathing/sleep apnea, both regarding demographics and cardiometabolic risk factors. Psychosocial stress factors acting as additional cardiometabolic risk factors were assessed. Among patients with persistent orofacial pain, increased risk of combination of insomnia and sleep disordered breathing/ sleep apnea was present in 11.5% of cases, and it was likely to increase psychosocial stress as an aditional independent risk factor for cardiometabolic disorder.
C1 [Meira E Cruz, Miguel] Ctr Cardiovasc Univ Lisboa CCULRISE, Lisbon Fac Med, Sleep Unit, Lisbon, Portugal.
   [Meira E Cruz, Miguel; Salles, Cristina] Int Ctr Clin Sleep Med & Res, Bahiana Sch Med & Publ Hlth, Salvador, Brazil.
   [Gozal, David] Marshall Univ, Joan C Edwards Sch Med, Huntington, WV USA.
   [Rocha, Isabel] Univ Lisbon, Fac Med, Ctr Cardiovasc, Cardiovasc Auton Funct Lab, Lisbon, Portugal.
   [Ettlin, Dominik] Univ Zurich, Ctr Dent Med, Zurich, Switzerland.
C3 Universidade de Lisboa; Marshall University; Universidade de Lisboa;
   University of Zurich
RP Cruz, MME (corresponding author), Ctr Cardiovasc Univ Lisboa CCULRISE, Lisbon Fac Med, Sleep Unit, Lisbon, Portugal.; Cruz, MME (corresponding author), Int Ctr Clin Sleep Med & Res, Bahiana Sch Med & Publ Hlth, Salvador, Brazil.
EM mcruz@medicina.ulisboa.pt
RI Gozal, David/M-9492-2017; Rocha, Isabel/A-4279-2013; Meira e Cruz,
   Miguel/AAS-3687-2020
OI Meira e Cruz, Miguel/0000-0001-6076-0878
CR Bastien CH, 2001, SLEEP MED, V2, P297, DOI 10.1016/S1389-9457(00)00065-4
   Cruz MME, 2023, J SLEEP RES, V32, DOI 10.1111/jsr.13705
   Ettlin DA, 2016, J HEADACHE PAIN, V17, DOI 10.1186/s10194-016-0670-5
   Hein M, 2022, SLEEP SCI, V15, P184, DOI 10.5935/1984-0063.20220018
   Kauffman BY, 2022, J BEHAV MED, V45, P297, DOI 10.1007/s10865-021-00262-6
   Löwe B, 2008, MED CARE, V46, P266, DOI 10.1097/MLR.0b013e318160d093
   Löwe B, 2010, J AFFECT DISORDERS, V122, P86, DOI 10.1016/j.jad.2009.06.019
   Cruz MME, 2021, AM J RESP CRIT CARE, V203, P1583, DOI 10.1164/rccm.202102-0337LE
   Cruz MME, 2019, FRONT NEUROL, V10, DOI 10.3389/fneur.2019.00542
   Osborne MT, 2020, CIRC-CARDIOVASC IMAG, V13, DOI 10.1161/CIRCIMAGING.120.010931
   Petrowski K, 2024, J AFFECT DISORDERS, V357, P37, DOI 10.1016/j.jad.2024.04.089
   Ren ZY, 2023, CHINA CDC WEEKLY, V5, P358, DOI 10.46234/ccdcw2023.068
   Reynolds CA, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24065378
   Rhudy JL, 2022, PAIN, V163, pE654, DOI 10.1097/j.pain.0000000000002458
   Rivero-Gallegos D, 2024, CLIN RHEUMATOL, V43, P1971, DOI 10.1007/s10067-024-06965-w
   Rodríguez-Sánchez I, 2022, J GERONTOL A-BIOL, V77, P204, DOI 10.1093/gerona/glab079
   Santosa A, 2021, JAMA NETW OPEN, V4, DOI 10.1001/jamanetworkopen.2021.38920
NR 17
TC 2
Z9 2
U1 1
U2 1
PU ORDEM MEDICOS
PI LISBON
PA AV ALMIRANTE GAGO COUTINHO, 151, LISBON, 1749-084, PORTUGAL
SN 0870-399X
EI 1646-0758
J9 ACTA MEDICA PORT
JI Acta Medica Port.
PD JAN
PY 2025
VL 38
IS 1
BP 37
EP 41
DI 10.20344/amp.22350
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA R3G8W
UT WOS:001390384800005
PM 39746313
OA gold
DA 2025-06-11
ER

PT J
AU Wen, Y
   Liu, GH
   Shang, YW
   Wang, Q
AF Wen, Yan
   Liu, Guohui
   Shang, Yawen
   Wang, Qing
TI Association of Depression with Metabolic Syndrome in Highly Educated
   Ethnic Koreans of China: A Case-Control Study
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Article
DE depression; metabolic syndrome; ethnic Koreans; self-rating scale for
   depression; waist circumference
ID REPRESENTATIVE SAMPLE; BIPOLAR DISORDER; RISK-FACTORS; ANXIETY;
   PREVALENCE; COMPONENTS; SYMPTOMS; OBESITY; METAANALYSIS; ADULTS
AB Background: Ethnic Koreans in China are a distinct minority group. Highly educated populations are at high risk of depression. The aim of this study was to explore the associations of depression and metabolic syndrome (MS) in highly educated ethnic Koreans in China, and determine whether the associations were dependent on gender.
   Methods: From March 11th to 27th 2017, the natural population of 18-70 year olds was continuously screened at Yanbian Korean Autonomous Region. Those who met the inclusion criteria were invited to complete Zung Self-Rating Depression Scale (SDS). The people with SDS 53 were assigned to depression group and those with SDS <= 53 were assigned to the control group. Demographic characteristics, clinical factors, life-style factors and family history were collected and compared. Besides, associations of depression with MS and its components were estimated by Spearman correlation analysis and logistic regression analysis. Results: The depression group included 367 highly educated ethnic Koreans with depression status and the control group consisted of 388 age-, education-, and gender matched ethnic Koreans without depression. A significantly higher prevalence of MS was observed in males and females with depression status relative to the control subjects (males, 28.5% vs 6.3%, X-2 = 16.162, P-value < 0.001; females, 33.0% vs 7.5%, X-2 = 57.896, P-value < 0.001). Depression status was positively correlated with MS in males (r = 0.311, P-value < 0.01) and females (r = 0.332, P-value < 0.01). After adjusting for potential confounding factors, mild and moderate depression statuses were found to be significantly associated with MS development in male and female ethnic Koreans, respectively.
   Conclusion: Our findings suggest a close link between depression and MS independent of gender in highly educated ethnic Koreans of China.
C1 [Wen, Yan; Shang, Yawen; Wang, Qing] Jilin Univ, Dept Endocrinol, China Japan Union Hosp, 126 Xian Tai St, Changchun 130033, Jilin, Peoples R China.
   [Liu, Guohui] Jilin Univ, Dept Cardiovasc, China Japan Union Hosp, Changchun 130033, Jilin, Peoples R China.
C3 Jilin University; Jilin University
RP Wang, Q (corresponding author), Jilin Univ, Dept Endocrinol, China Japan Union Hosp, 126 Xian Tai St, Changchun 130033, Jilin, Peoples R China.
EM wang_qing@jlu.edu.cn
FU National Key R&D Program of China [2016YFC1305700]; National Key
   Scientific Instrument and Equipment Development Project of China
   [51627808]
FX This work was supported by National Key R&D Program of China (Program
   No. 2016YFC1305700) and the National Key Scientific Instrument and
   Equipment Development Project of China (Program No. 51627808).
CR Camacho A, 2013, MED HYPOTHESES, V81, P577, DOI 10.1016/j.mehy.2013.07.006
   Dall TM, 2014, DIABETES CARE, V37, P3172, DOI 10.2337/dc14-1036
   Dunstan DA, 2019, BMC PSYCHIATRY, V19, DOI 10.1186/s12888-019-2161-0
   Dunstan DA, 2017, BMC PSYCHIATRY, V17, DOI 10.1186/s12888-017-1489-6
   Gheshlagh RG, 2016, IRAN RED CRESCENT ME, V18, DOI 10.5812/ircmj.26523
   Grover S, 2017, ASIAN J PSYCHIATR, V27, P139, DOI 10.1016/j.ajp.2017.02.030
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Han KM, 2019, J AFFECT DISORDERS, V257, P486, DOI 10.1016/j.jad.2019.07.003
   Hildrum B, 2009, ACTA PSYCHIAT SCAND, V120, P14, DOI 10.1111/j.1600-0447.2008.01315.x
   Hiles SA, 2016, DEPRESS ANXIETY, V33, P754, DOI 10.1002/da.22512
   Ibrahim AK, 2013, J PSYCHIATR RES, V47, P391, DOI 10.1016/j.jpsychires.2012.11.015
   Jabben N, 2011, J PSYCHIATR RES, V45, P1208, DOI 10.1016/j.jpsychires.2011.03.010
   Ko JK, 2019, J AFFECT DISORDERS, V249, P319, DOI 10.1016/j.jad.2019.02.049
   Lasserre AM, 2014, JAMA PSYCHIAT, V71, P880, DOI 10.1001/jamapsychiatry.2014.411
   Lazarevich I, 2016, APPETITE, V107, P639, DOI 10.1016/j.appet.2016.09.011
   Li Jianxin, 2014, Zhonghua Liu Xing Bing Xue Za Zhi, V35, P349
   Li R, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-2870-y
   Licht CMM, 2010, J CLIN ENDOCR METAB, V95, P2458, DOI 10.1210/jc.2009-2801
   Maes M, 2008, NEUROENDOCRINOL LETT, V29, P287
   Maes M, 2011, NEUROENDOCRINOL LETT, V32, P7
   Marazziti D, 2014, CNS SPECTRUMS, V19, P293, DOI 10.1017/S1092852913000667
   Mattei G, 2018, J NERV MENT DIS, V206, P316, DOI 10.1097/NMD.0000000000000807
   McIntyre RS, 2009, CURR DIABETES REP, V9, P51, DOI 10.1007/s11892-009-0010-0
   Moreira FP, 2017, J PSYCHIATR RES, V92, P119, DOI 10.1016/j.jpsychires.2017.03.025
   Olvera RL, 2015, J CLIN PSYCHIAT, V76, pE1300, DOI 10.4088/JCP.14m09118
   Othman N, 2019, INT J MENT HEALTH SY, V13, DOI 10.1186/s13033-019-0275-x
   Oxenkrug GF, 2010, ANN NY ACAD SCI, V1199, P1, DOI 10.1111/j.1749-6632.2009.05356.x
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Park SJ, 2016, J AFFECT DISORDERS, V205, P393, DOI 10.1016/j.jad.2016.08.022
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Punthakee Z, 2018, CAN J DIABETES, V42, pS10, DOI 10.1016/j.jcjd.2017.10.003
   Rioli G, 2019, J NERV MENT DIS, V207, P340, DOI 10.1097/NMD.0000000000000969
   Rochlani Y, 2015, CARDIOVASC DRUG THER, V29, P329, DOI 10.1007/s10557-015-6593-6
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sekita A, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-862
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Tang F, 2017, PSYCHONEUROENDOCRINO, V77, P112, DOI 10.1016/j.psyneuen.2016.11.025
   Toker S, 2008, DEPRESS ANXIETY, V25, P661, DOI 10.1002/da.20379
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vanhala M, 2009, ACTA PSYCHIAT SCAND, V119, P137, DOI 10.1111/j.1600-0447.2008.01283.x
   Viinamäki H, 2009, ACTA PSYCHIAT SCAND, V120, P23, DOI 10.1111/j.1600-0447.2008.01333.x
   Wang C., 2009, Chin. J. Nervous Ment. Dis., V12, P267
   WHO, 1982, Guidelines for the conduct of tobacco smoking surveys of the general population report
   Yin WY, 2015, ADDICTION, V110, P51, DOI 10.1111/add.12780
   Yu SS, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-016-3913-0
   Zarouna Stalo, 2015, World J Exp Med, V5, P103, DOI 10.5493/wjem.v5.i2.103
   ZUNG WWK, 1965, ARCH GEN PSYCHIAT, V12, P63, DOI 10.1001/archpsyc.1965.01720310065008
NR 47
TC 1
Z9 1
U1 1
U2 6
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2021
VL 17
BP 57
EP 66
DI 10.2147/NDT.S280716
PG 10
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA QG1PC
UT WOS:000617361700001
PM 33447037
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kaminska, MS
   Cybulska, AM
   Panczyk, M
   Baranowska-Bosiacka, I
   Chlubek, D
   Grochans, E
   Stanislawska, M
   Jurczak, A
AF Kaminska, Magdalena Sylwia
   Cybulska, Anna Maria
   Panczyk, Mariusz
   Baranowska-Bosiacka, Irena
   Chlubek, Dariusz
   Grochans, Elzbieta
   Stanislawska, Marzanna
   Jurczak, Anna
TI The Effect of Whole Blood Lead (Pb-B) Levels on Changes in Peripheral
   Blood Morphology and Selected Biochemical Parameters, and the Severity
   of Depression in Peri-Menopausal Women at Risk of Metabolic Syndrome or
   with Metabolic Syndrome
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE Pb-B; metabolic syndrome; menopause; depression
ID PUBERTAL DEVELOPMENT; OXIDATIVE STRESS; NATIONAL-HEALTH;
   CARDIOVASCULAR-DISEASE; POSTMENOPAUSAL WOMEN; ALCOHOL-CONSUMPTION;
   ARTERIAL STIFFNESS; VASOMOTOR SYMPTOMS; EXPOSURE; ASSOCIATION
AB The aim of our study was to assess the impact of whole blood lead (Pb-B) levels on changes in peripheral blood morphology and selected biochemical parameters, and the severity of depression in peri-menopausal women at risk of metabolic syndrome (pre-MetS) or with metabolic syndrome (MetS). The study involved 233 women from the general population of the West Pomeranian Province (Poland) aged 44-65 years. The intensity of menopausal symptoms and the severity of depression was examined using the Blatt-Kupperman Index (KI) and the Beck Depression Inventory (BDI). C-reactive protein (CRP), insulin, glucose, glycated hemoglobin (HbA1C), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, triglyceride levels (TG), cortisol, morphology of blood cells and homeostasis model assessment for insulin resistance (HOMA-IR) and Pb-B was measured. Women with MetS had higher levels of glucose, HbA1C, HDL, LDL, TG, cortisol, insulin and higher HOMA-IR. No significant differences in Pb-B were observed between pre-MetS and the control group, and between pre-MetS and the MetS group. A significant correlation was noticed between Pb-B vs. the percentage of monocytes in blood, and blood cortisol levels in women with MetS; Pb-B vs. lymphocyte count and HbA1C in the pre-MetS group, as well as in the BDI scores between the MetS and pre-MetS group. We cannot clearly state that exposure to Pb is an environmental factor that can be considered as a risk factor for MetS in this studied group.
C1 [Kaminska, Magdalena Sylwia] Pomeranian Med Univ, Fac Hlth Sci, Subdept Long Term Care, Dept Social Med, 48 Zolnierska St, PL-71210 Szczecin, Poland.
   [Cybulska, Anna Maria; Grochans, Elzbieta; Stanislawska, Marzanna] Pomeranian Med Univ, Fac Hlth Sci, Dept Nursing, 48 Zolnierska St, PL-71210 Szczecin, Poland.
   [Panczyk, Mariusz] Med Univ Warsaw, Fac Hlth Sci, Dept Educ & Res Hlth Sci, 81 Zwirki & Wigury St, PL-02091 Warsaw, Poland.
   [Baranowska-Bosiacka, Irena; Chlubek, Dariusz] Pomeranian Med Univ, Dept Biochem & Med Chem, 72 Powstancow Wielkopolskich St, PL-70111 Szczecin, Poland.
   [Jurczak, Anna] Pomeranian Med Univ, Fac Hlth Sci, Dept Specialized Nursing, PL-70210 Szczecin, Poland.
C3 Pomeranian Medical University; Pomeranian Medical University; Medical
   University of Warsaw; Pomeranian Medical University; Pomeranian Medical
   University
RP Cybulska, AM (corresponding author), Pomeranian Med Univ, Fac Hlth Sci, Dept Nursing, 48 Zolnierska St, PL-71210 Szczecin, Poland.
EM magdalena.kaminska@pum.edu.pl; anna.cybulska@pum.edu.pl;
   mariusz.panczyk@wum.edu.pl; ika@pum.edu.pl; dchlubek@pum.edu.pl;
   grochans@pum.edu.pl; stamarz@pum.edu.pl; anna.jurczak@pum.edu.pl
RI Chlubek, Dariusz/J-6310-2014; Grochans, Elżbieta/K-8659-2014; Cybulska,
   Anna/AAV-5966-2020; Jurczak, Anna/K-8913-2014; Panczyk,
   Mariusz/B-4412-2011; Kaminska, Magdalena/O-7349-2014; Stanislawska,
   Marzanna/O-7349-2014; Grochans, Elzbieta/M-1593-2014
OI Jurczak, Anna/0000-0003-1935-5285; Panczyk, Mariusz/0000-0003-1830-2114;
   Cybulska, Anna Maria/0000-0002-6912-287X; Baranowska-Bosiacka,
   Irena/0000-0001-9187-8895; Kaminska, Magdalena/0000-0003-4795-033X;
   Stanislawska, Marzanna/0000-0002-4867-9732; Chlubek,
   Dariusz/0000-0003-4497-4395; Grochans, Elzbieta/0000-0002-3679-7002
FU Minister of Science and Higher Education under the name 'Regional
   initiative of excellence' [002/RID/2018/19]
FX This project is financed from the program of the Minister of Science and
   Higher Education under the name 'Regional initiative of excellence' in
   2019-2020 (Project number 002/RID/2018/19; Amount of financing
   12.000.000 PLN).
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Alghasham AA, 2011, INT J HEALTH SCI-IJH, V5, P19
   [Anonymous], 2012, Report of the Advisory Committee
   Ansarimoghaddam A, 2018, DIABETES METAB SYND, V12, P195, DOI 10.1016/j.dsx.2017.11.004
   Arenillas JF, 2007, STROKE, V38, P2196, DOI 10.1161/STROKEAHA.106.480004
   Baranowska-Bosiacka I., 2015, CHILDREN BIOL TRACE, V170, P279, DOI [10.1007/s12011-015-0482-5, DOI 10.1007/S12011-015-0482-5]
   Basha R, 2010, INDIAN J EXP BIOL, V48, P636
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   Binns HJ, 2007, PEDIATRICS, V120, pE1285, DOI 10.1542/peds.2005-1770
   Bupp MRG, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01269
   Campbell N, 2017, KIDNEY INT REP, V2, P733, DOI 10.1016/j.ekir.2017.02.009
   Carrier A, 2017, ANTIOXID REDOX SIGN, V26, P429, DOI 10.1089/ars.2016.6929
   CDC Centers for Disease Control and Prevention National Centres for Environmental Health Preventing, 2005, LEAD POIS YOUNG CHIL
   Cengiz H, 2019, J OBSTET GYNAECOL, V39, P529, DOI 10.1080/01443615.2018.1534812
   Chedraui P., 2007, Archives of Gynecology and Obstetrics, V275, P161, DOI 10.1007/s00404-006-0239-7
   Chibowska K, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21031083
   Chibowska K, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17122140
   Cory-Slechta DA, 2004, ENVIRON HEALTH PERSP, V112, P717, DOI 10.1289/ehp.6481
   Cory-Slechta DA, 2008, BASIC CLIN PHARMACOL, V102, P218, DOI 10.1111/j.1742-7843.2007.00189.x
   de Marchi R, 2017, ARCH ENDOCRIN METAB, V61, P160, DOI 10.1590/2359-3997000000253
   Dearth RK, 2004, LIFE SCI, V74, P1139, DOI 10.1016/j.lfs.2003.07.033
   Dearth RK, 2002, REPROD TOXICOL, V16, P343, DOI 10.1016/S0890-6238(02)00037-0
   Blümel JE, 2011, MATURITAS, V70, P207, DOI 10.1016/j.maturitas.2011.07.002
   Ervin R Bethene, 2009, Natl Health Stat Report, P1
   Fan Y, 2020, BIOL TRACE ELEM RES, V194, P76, DOI 10.1007/s12011-019-01755-x
   Faulkner JL, 2019, BIOL SEX DIFFER, V10, DOI 10.1186/s13293-019-0246-6
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   Freeman EW, 2006, ARCH GEN PSYCHIAT, V63, P375, DOI 10.1001/archpsyc.63.4.375
   Freiberg MS, 2004, DIABETES CARE, V27, P2954, DOI 10.2337/diacare.27.12.2954
   Gassowska M, 2016, TOXICOLOGY, V347, P17, DOI 10.1016/j.tox.2016.03.002
   Gassowska M, 2016, TOXICOLOGY, V373, P13, DOI 10.1016/j.tox.2016.10.014
   Gheshlagh RG, 2016, IRAN RED CRESCENT ME, V18, DOI 10.5812/ircmj.26523
   Giel-Pietraszuk M, 2012, POSTEPY BIOL KOMORKI, V39, P217
   Ginsberg Henry N, 2009, J Cardiometab Syndr, V4, P113, DOI 10.1111/j.1559-4572.2008.00044.x
   Grabecki J, 1993, Med Pr, V44, P85
   Grandl G, 2018, SEMIN IMMUNOPATHOL, V40, P215, DOI 10.1007/s00281-017-0666-5
   Hallajzadeh J, 2018, MENOPAUSE, V25, P1155, DOI 10.1097/GME.0000000000001136
   Herber-Gast GCM, 2015, BJOG-INT J OBSTET GY, V122, P1560, DOI 10.1111/1471-0528.13163
   Jakubowski M, 1996, INT ARCH OCC ENV HEA, V68, P193, DOI 10.1007/BF00381631
   Jakubowski M, 1993, Med Pr, V44, P15
   Jang WH, 2011, TOXICOL SCI, V122, P177, DOI 10.1093/toxsci/kfr079
   John G., 2019, J BIOMED CLIN RES, V12, P9, DOI [10.2478/jbcr-2019-0001, DOI 10.2478/JBCR-2019-0001]
   Jomova K, 2011, TOXICOLOGY, V283, P65, DOI 10.1016/j.tox.2011.03.001
   KUPPERMAN HS, 1959, JAMA-J AM MED ASSOC, V171, P1627, DOI 10.1001/jama.1959.03010300001001
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lambrinoudaki I, 2018, HEART LUNG CIRC, V27, P716, DOI 10.1016/j.hlc.2017.05.142
   Lambrinoudaki I, 2018, GYNECOL ENDOCRINOL, V34, P78, DOI 10.1080/09513590.2017.1344208
   Lanphear BP, 2018, LANCET PUBLIC HEALTH, V3, pE177, DOI 10.1016/S2468-2667(18)30025-2
   Lee BK, 2016, BIOL TRACE ELEM RES, V171, P6, DOI 10.1007/s12011-015-0499-9
   Lejsková M, 2011, CLIMACTERIC, V14, P83, DOI 10.3109/13697131003692745
   Liu Y, 2019, ENVIRON INT, V125, P445, DOI 10.1016/j.envint.2019.02.021
   Marotz Clarisse A., 2016, Yale Journal of Biology and Medicine, V89, P383
   Mathieu P, 2006, VASC HEALTH RISK MAN, V2, P285, DOI 10.2147/vhrm.2006.2.3.285
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   Meun C, 2018, J CLIN ENDOCR METAB, V103, P1622, DOI 10.1210/jc.2017-02421
   Min YS, 2017, SCAND J WORK ENV HEA, V43, P385, DOI 10.5271/sjweh.3631
   Mishra KP, 2009, TOXICOL IN VITRO, V23, P969, DOI 10.1016/j.tiv.2009.06.014
   Moneim AEA, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0158965
   Montgomery MK, 2015, ENDOCR CONNECT, V4, DOI 10.1530/EC-14-0092
   Moon SS, 2014, ENDOCRINE, V46, P263, DOI 10.1007/s12020-013-0061-5
   Moreira GC, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0105056
   Naicker N, 2010, SCI TOTAL ENVIRON, V408, P4949, DOI 10.1016/j.scitotenv.2010.07.037
   Nakhjavani M, 2014, J DIABETES METAB DIS, V13, DOI 10.1186/s40200-014-0102-5
   Owsianowska J, 2020, J TRACE ELEM MED BIO, V61, DOI 10.1016/j.jtemb.2020.126501
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Parikh Rakesh M, 2012, Indian J Endocrinol Metab, V16, P7, DOI 10.4103/2230-8210.91175
   Parsanathan R, 2020, METAB SYNDR RELAT D, V18, P10, DOI 10.1089/met.2019.0073
   Pickering TG, 2005, CIRCULATION, V111, P697, DOI 10.1161/01.CIR.0000154900.76284.F6
   Planchart A, 2018, CURR ENV HLTH REP, V5, P110, DOI 10.1007/s40572-018-0182-3
   Pu D, 2017, CLIMACTERIC, V20, P583, DOI 10.1080/13697137.2017.1386649
   Räikkönen K, 2007, DIABETES CARE, V30, P872, DOI 10.2337/dc06-1857
   Regitz-Zagrosek V, 2007, GENDER MED, V4, pS162, DOI 10.1016/S1550-8579(07)80056-8
   Rhee SY, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-9
   Rossi-George A, 2009, TOXICOL APPL PHARM, V234, P117, DOI 10.1016/j.taap.2008.10.003
   Ryu KJ, 2015, MENOPAUSE, V22, P1239, DOI 10.1097/GME.0000000000000461
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sassarini DJ, 2016, MATURITAS, V94, P149, DOI 10.1016/j.maturitas.2016.09.004
   Scuteri A, 2015, EUR J PREV CARDIOL, V22, P486, DOI 10.1177/2047487314525529
   Slawinska T, 2012, AM J HUM BIOL, V24, P587, DOI 10.1002/ajhb.22272
   Soares CN, 2017, PSYCHIAT CLIN N AM, V40, P239, DOI 10.1016/j.psc.2017.01.007
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Sun K, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047791
   Sun K, 2014, CLIN NUTR, V33, P596, DOI 10.1016/j.clnu.2013.10.003
   Svaina, 2019, VNITR LEK, V64, P1156, DOI [10.36290/vnl.2018.166, DOI 10.36290/VNL.2018.166]
   Tabatabaei-Malazy O, 2018, J DIABETES METAB DIS, V17, P357, DOI 10.1007/s40200-018-0375-1
   Tornatore L, 2012, TRENDS CELL BIOL, V22, P557, DOI 10.1016/j.tcb.2012.08.001
   Trikudanathan S, 2013, J CLIN ENDOCR METAB, V98, P236, DOI 10.1210/jc.2012-1785
   van Dijk GM, 2015, MATURITAS, V80, P140, DOI 10.1016/j.maturitas.2014.11.016
   van Vliet-Ostaptchouk JV, 2014, BMC ENDOCR DISORD, V14, DOI 10.1186/1472-6823-14-9
   Vidigal FD, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/s13098-015-0003-x
   Vishram JKK, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0107294
   Vivian-Taylor J, 2014, MATURITAS, V79, P142, DOI 10.1016/j.maturitas.2014.05.014
   Vreeburg SA, 2009, ARCH GEN PSYCHIAT, V66, P617, DOI 10.1001/archgenpsychiatry.2009.50
   WHO, 2011, CIRC WAIST HIP RAT R
   Wilsgaard T, 2007, DIABETES RES CLIN PR, V78, P217, DOI 10.1016/j.diabres.2007.03.006
   Wolff MS, 2008, ENVIRON RES, V107, P393, DOI 10.1016/j.envres.2008.03.006
   Wyrzykowski B., 2005, KARDIOL POL, V63, P1
   Yin QQ, 2013, J OBSTET GYNAECOL RE, V39, P203, DOI 10.1111/j.1447-0756.2012.01907.x
   Zdrojewski T., 2004, Kardiol Pol, V61, P5
   Zimet Z, 2017, BIOMED ENVIRON SCI, V30, P841, DOI 10.3967/bes2017.113
NR 101
TC 14
Z9 14
U1 0
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD JUL
PY 2020
VL 17
IS 14
AR 5033
DI 10.3390/ijerph17145033
PG 18
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA MX2KZ
UT WOS:000557556200001
PM 32668760
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Brooks, SD
   Hileman, SM
   Chantler, PD
   Milde, SA
   Lemaster, KA
   Frisbee, SJ
   Shoemaker, JK
   Jackson, DN
   Frisbee, JC
AF Brooks, Steven D.
   Hileman, Stanley M.
   Chantler, Paul D.
   Milde, Samantha A.
   Lemaster, Kent A.
   Frisbee, Stephanie J.
   Shoemaker, J. Kevin
   Jackson, Dwayne N.
   Frisbee, Jefferson C.
TI Protection from chronic stress- and depressive symptom-induced vascular
   endothelial dysfunction in female rats is abolished by preexisting
   metabolic disease
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE cardiovascular risk factors; chronic stress; clinical depression;
   endothelial dysfunction; metabolic syndrome; sex disparities;
   vasodilation
ID NITRIC-OXIDE; CARDIOVASCULAR-DISEASE; SEX-DIFFERENCES; MODEL;
   MECHANISMS; REACTIVITY; BEHAVIOR; OBESITY; ARTERIOLES; ACTIVATION
AB While it is known that chronic stress and clinical depression are powerful predictors of poor cardiovascular outcomes, recent clinical evidence has identified correlations between the development of metabolic disease and depressive symptoms, creating a combined condition of severely elevated cardiovascular disease risk. In this study, we used the obese Zucker rat (OZRs) and the unpredictable chronic mild stress (UCMS) model to determine the impact of preexisting metabolic disease on the relationship between chronic stress/depressive symptoms and vascular function. Additionally, we determined the impact of metabolic syndrome on sex-based protection from chronic stress/depressive effects on vascular function in female lean Zucker rats (LZRs). In general, vasodilator reactivity was attenuated under control conditions in OZRs compared with LZRs. Although still impaired. conduit arterial and resistance arteriolar dilator reactivity under control conditions in female OZRs was superior to that in male or ovariectomized (OVX) female OZRs, largely because of better maintenance of vascular nitric oxide and prostacyclin levels. However, imposition of metabolic syndrome in combination with UCMS in OZRs further impaired dilator reactivity in both vessel subtypes to a similarly severe extent and abolished any protective effect in female rats compared with male or OVX female rats. The loss of vascular protection in female OZRs with UCMS was reflected in vasodilator metabolite levels, which closely matched those in male and OVX female OZRs subjected to UCMS. These results suggest that presentation of metabolic disease in combination with depressive symptoms can overwhelm the vasoprotection identified in female rats and, thereby, may reflect a severe impairment to normal endothelial function.
   NEW & NOTEWORTHY This study addresses the protection from chronic stress- and depression-induced vascular dysfunction identified in female compared with male or ovariectomized female rats. We determined the impact of preexisting metabolic disease, a frequent comorbidity of clinical depression in humans, on that vascular protection. With preexisting metabolic syndrome, female rats lost all protection from chronic stress/depressive symptoms and became phenotypically similar to male and ovariectomized female rats, with comparably poor vasoactive dilator metabolite profiles.
C1 [Brooks, Steven D.; Hileman, Stanley M.] West Virginia Univ, Dept Physiol & Pharmacol, Morgantown, WV USA.
   [Chantler, Paul D.] West Virginia Univ, Dept Exercise Physiol, Morgantown, WV USA.
   [Milde, Samantha A.; Shoemaker, J. Kevin; Frisbee, Jefferson C.] Univ Western Ontario, Fac Hlth Sci, Schulich Sch Med & Dent, Dept Physiol & Pharmacol, London, ON, Canada.
   [Lemaster, Kent A.; Jackson, Dwayne N.; Frisbee, Jefferson C.] Univ Western Ontario, Fac Hlth Sci, Schulich Sch Med & Dent, Dept Med Biophys, London, ON, Canada.
   [Frisbee, Stephanie J.] Univ Western Ontario, Fac Hlth Sci, Schulich Sch Med & Dent, Dept Pathol & Lab Med, London, ON, Canada.
   [Frisbee, Stephanie J.] Univ Western Ontario, Fac Hlth Sci, Schulich Sch Med & Dent, Dept Epidemiol & Biostat, London, ON, Canada.
   [Shoemaker, J. Kevin] Univ Western Ontario, Sch Kinesiol, London, ON, Canada.
C3 West Virginia University; West Virginia University; Western University
   (University of Western Ontario); Western University (University of
   Western Ontario); Western University (University of Western Ontario);
   Western University (University of Western Ontario); Western University
   (University of Western Ontario)
RP Frisbee, SJ (corresponding author), Univ Western Ontario, 1151 N Richmond Dr, London, ON N6A 5C1, Canada.
EM jfrisbee@uwo.ca
RI Jackson, Dwayne/E-4153-2015; Shoemaker, Kevin/L-2682-2013
OI Frisbee, Jefferson/0000-0003-2751-0599; Shoemaker,
   Kevin/0000-0002-6794-5979; Frisbee, Stephanie/0000-0003-1526-1839
FU American Heart Association Grants [IRG 14330015, PRE 16850005, EIA
   0740129N]; National Institutes of Health Grant [RR-2865AR]; Canadian
   Natural Sciences and Engineering Research Council Grant [R4081A03]
FX This study was supported by American Heart Association Grants IRG
   14330015, PRE 16850005, and EIA 0740129N; National Institutes of Health
   Grant RR-2865AR; and Canadian Natural Sciences and Engineering Research
   Council Grant R4081A03.
CR Adibfar A, 2016, CURR MOL MED, V16, P137, DOI 10.2174/1566524016666160126144143
   American Heart Association, 2017, MET SYNDR
   Bangasser DA, 2014, FRONT NEUROENDOCRIN, V35, P303, DOI 10.1016/j.yfrne.2014.03.008
   BAUMBACH GL, 1993, HYPERTENSION, V21, P816, DOI 10.1161/01.HYP.21.6.816
   Bayramgurler D, 2013, EUR J PHARMACOL, V710, P67, DOI 10.1016/j.ejphar.2013.04.007
   Beyer AM, 2014, AM J PHYSIOL-HEART C, V307, pH1587, DOI 10.1152/ajpheart.00557.2014
   Boese AC, 2017, AM J PHYSIOL-HEART C, V313, pH524, DOI 10.1152/ajpheart.00217.2016
   Booth FW, 2017, PHYSIOL REV, V97, P1351, DOI 10.1152/physrev.00019.2016
   Brooks SD, 2018, AM J PHYSIOL-HEART C, V314, pH1070, DOI 10.1152/ajpheart.00647.2017
   Brooks SD, 2015, AM J PHYSIOL-HEART C, V309, pH1846, DOI 10.1152/ajpheart.00691.2015
   Bulun SE, 2012, TRENDS ENDOCRIN MET, V23, P83, DOI 10.1016/j.tem.2011.10.003
   Butcher JT, 2013, MICROCIRCULATION, V20, P579, DOI 10.1111/micc.12056
   Cappuccio FP, 2017, CURR CARDIOL REP, V19, DOI 10.1007/s11886-017-0916-0
   CATELLA F, 1986, P NATL ACAD SCI USA, V83, P5861, DOI 10.1073/pnas.83.16.5861
   Chakrabarti S, 2014, CAN J CARDIOL, V30, P705, DOI 10.1016/j.cjca.2013.08.006
   Chauvet-Gelinier JC, 2017, ANN PHYS REHABIL MED, V60, P6, DOI 10.1016/j.rehab.2016.09.002
   d'Audiffret AC, 2010, J APPL PHYSIOL, V108, P1041, DOI 10.1152/japplphysiol.01440.2009
   Davies PF, 2013, CARDIOVASC RES, V99, P315, DOI 10.1093/cvr/cvt101
   Demirtas T, 2014, INFLAMMATION, V37, P1432, DOI 10.1007/s10753-014-9867-4
   Evans CEL, 2017, AM J CLIN NUTR, V105, P1176, DOI 10.3945/ajcn.116.143685
   Fellmann L, 2013, PHARMACOL THERAPEUT, V137, P331, DOI 10.1016/j.pharmthera.2012.11.004
   Finch J, 2016, CARDIOVASC TOXICOL, V16, P260, DOI 10.1007/s12012-015-9334-y
   Frisbee JC, 2015, JOVE-J VIS EXP, DOI 10.3791/53109
   Go AS, 2013, CIRCULATION, V127, P143, DOI [10.1161/CIR.0b013e318282ab8f, 10.1161/CIR.0000000000000366]
   Golbidi S, 2015, AM J PHYSIOL-HEART C, V308, pH1476, DOI 10.1152/ajpheart.00859.2014
   Halaris A, 2017, CURR TOP BEHAV NEURO, V31, P45, DOI 10.1007/7854_2016_28
   Isingrini E, 2011, PHYSIOL BEHAV, V103, P540, DOI 10.1016/j.physbeh.2011.04.002
   Kessler RC, 2003, J AFFECT DISORDERS, V74, P5, DOI 10.1016/S0165-0327(02)00426-3
   KESSLER RC, 1993, J AFFECT DISORDERS, V29, P85, DOI 10.1016/0165-0327(93)90026-G
   Knapen J, 2015, DISABIL REHABIL, V37, P1490, DOI 10.3109/09638288.2014.972579
   Kypreos KE, 2014, J CARDIOVASC PHARM T, V19, P256, DOI 10.1177/1074248413513499
   Lin YT, 2016, PSYCHONEUROENDOCRINO, V71, P73, DOI 10.1016/j.psyneuen.2016.05.014
   Liu YZ, 2017, FRONT HUM NEUROSCI, V11, DOI 10.3389/fnhum.2017.00316
   Lombard JH, 1999, AM J PHYSIOL-HEART C, V276, pH509, DOI 10.1152/ajpheart.1999.276.2.H509
   Marazziti D, 2014, CNS SPECTRUMS, V19, P293, DOI 10.1017/S1092852913000667
   Morange PE, 2013, THROMB HAEMOSTASIS, V110, P669, DOI 10.1160/TH13-01-0075
   NIES AS, 1986, CLIN PHARMACOL THER, V39, P481, DOI 10.1038/clpt.1986.84
   Phillips SA, 2005, AM J PHYSIOL-REG I, V288, pR522, DOI 10.1152/ajpregu.00655.2004
   Phillips SA, 2015, PROG CARDIOVASC DIS, V57, P521, DOI 10.1016/j.pcad.2014.12.005
   Pulliero A, 2015, INT J HYG ENVIR HEAL, V218, P293, DOI 10.1016/j.ijheh.2015.01.007
   Regitz-Zagrosek V, 2006, NAT REV DRUG DISCOV, V5, P425, DOI 10.1038/nrd2032
   Scallan JP, 2016, J PHYSIOL-LONDON, V594, P5749, DOI 10.1113/JP272088
   Sharifi M, 2016, HEART, V102, P1003, DOI 10.1136/heartjnl-2015-308845
   Sieve I, 2018, VASC PHARMACOL, V100, P26, DOI 10.1016/j.vph.2017.09.002
   Stanley SC, 2014, J APPL PHYSIOL, V117, P959, DOI 10.1152/japplphysiol.00537.2014
   Stedenfeld KA, 2011, PHYSIOL BEHAV, V103, P210, DOI 10.1016/j.physbeh.2011.02.001
   Tofovic SP, 2003, METH MOLEC MED, V86, P29
   Tsuji JS, 2014, TOXICOLOGY, V323, P78, DOI 10.1016/j.tox.2014.06.008
   Vargas J, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0162665
   Willner P, 1997, PSYCHOPHARMACOLOGY, V134, P319, DOI 10.1007/s002130050456
   Willner P, 2017, NEUROBIOL STRESS, V6, P78, DOI 10.1016/j.ynstr.2016.08.002
   Wirtz PH, 2017, CURR CARDIOL REP, V19, DOI 10.1007/s11886-017-0919-x
NR 52
TC 16
Z9 17
U1 0
U2 4
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD MAY
PY 2018
VL 314
IS 5
BP H1085
EP H1097
DI 10.1152/ajpheart.00648.2017
PG 13
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA GP8EQ
UT WOS:000441143200019
PM 29451819
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU de Keijzer, C
   Bauwelinck, M
   Dadvand, P
AF de Keijzer, Carmen
   Bauwelinck, Mariska
   Dadvand, Payam
TI Long-Term Exposure to Residential Greenspace and Healthy Ageing: a
   Systematic Review
SO CURRENT ENVIRONMENTAL HEALTH REPORTS
LA English
DT Review
DE Natural environment; Elderly; Health; Greenspace; Ageing; Park
ID PHYSICAL-ACTIVITY; OLDER-ADULTS; NEIGHBORHOOD ENVIRONMENT; BUILT
   ENVIRONMENT; MENTAL-HEALTH; COGNITIVE FUNCTION; BLUE SPACES; DEPRESSIVE
   SYMPTOMS; ELDERLY RESIDENTS; AIR-POLLUTION
AB Purpose of ReviewWe systematically reviewed the available observational evidence on the association between long-term exposure to residential outdoor greenspace and health at older age and rated the evidence as sufficient, limited, or inadequate.Recent FindingsWe identified 59 studies, ranging from poor to very good quality. The health outcomes included mental health (N=12, of which three were longitudinal studies and eight were rated to be of good quality), cognitive function (N=6; two longitudinal studies, five of good/very good quality), physical capability (N=22; five longitudinal studies, six of good/very good quality), cardiometabolic risk (N=9; one longitudinal study, five of good/very good quality), morbidity (N=11; three longitudinal studies, six of good/very good quality) and perceived wellbeing (N=9; all cross-sectional, two of good quality). The evidence for a beneficial association with greenspace was rated limited for morbidity and inadequate for mental health, cognitive function, physical capability, cardiometabolic risk and perceived wellbeing.SummaryThe reviewed studies provided inadequate/limited but suggestive evidence for a beneficial association between greater long-term greenspace exposure and healthy ageing. This review highlights the need of longitudinal studies that assess the association between long-term greenspace exposure and the trajectory of objective indicators of ageing.
C1 [de Keijzer, Carmen; Dadvand, Payam] Barcelona Biomed Res Pk PRBB, Inst Salud Global Barcelona ISGlobal, Doctor Aiguader 88, Barcelona 08003, Spain.
   [de Keijzer, Carmen; Dadvand, Payam] Univ Pompeu Fabra UPF, Barcelona, Spain.
   [de Keijzer, Carmen; Dadvand, Payam] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.
   [Bauwelinck, Mariska] Res Fdn Flanders FWO, Brussels, Belgium.
   [Bauwelinck, Mariska] Vrije Univ Brussel, Dept Sociol, Interface Demog ID, Brussels, Belgium.
C3 ISGlobal; Pompeu Fabra University; Barcelona Biomedical Research Park;
   Pompeu Fabra University; CIBER - Centro de Investigacion Biomedica en
   Red; CIBERESP; Vrije Universiteit Brussel
RP Dadvand, P (corresponding author), Barcelona Biomed Res Pk PRBB, Inst Salud Global Barcelona ISGlobal, Doctor Aiguader 88, Barcelona 08003, Spain.; Dadvand, P (corresponding author), Univ Pompeu Fabra UPF, Barcelona, Spain.; Dadvand, P (corresponding author), CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.
EM payam.dadvand@isglobal.org
RI Dadvand, Payam/O-8053-2018
OI Bauwelinck, Mariska/0000-0002-6117-2135
FU Research Foundation-Flanders (FWO) [11A9718N]; Gustave Boel-Sofina
   Fellowship [V422218N]; Ramon y Cajal fellowships - Spanish Ministry of
   Economy and Competitiveness [RYC-2012-10995]
FX Mariska Bauwelinck is funded by an individual PhD grant supported by the
   Research Foundation-Flanders (FWO) (grant number 11A9718N) and a Gustave
   Boel-Sofina Fellowship (grant number V422218N). PD [RYC-2012-10995] is
   funded by Ramon y Cajal fellowships awarded by the Spanish Ministry of
   Economy and Competitiveness. The funders have not been involved in any
   part of the study design or reporting.
CR Astell-Burt T, 2014, INT J OBESITY, V38, P156, DOI 10.1038/ijo.2013.64
   Astell-Burt T, 2014, J EPIDEMIOL COMMUN H, V68, P578, DOI 10.1136/jech-2013-203767
   Astell-Burt T, 2014, J EPIDEMIOL COMMUN H, V68, P370, DOI 10.1136/jech-2013-203043
   Astell-Burt T, 2014, BRIT J SPORT MED, V48, DOI 10.1136/bjsports-2012-092006
   Astell-Burt T, 2014, DIABETES CARE, V37, P197, DOI 10.2337/dc13-1325
   Astell-Burt T, 2013, PREV MED, V57, P601, DOI 10.1016/j.ypmed.2013.08.017
   Banay RF, 2019, ENVIRON HEALTH PERSP, V127, DOI 10.1289/EHP1229
   Berman MG, 2008, PSYCHOL SCI, V19, P1207, DOI 10.1111/j.1467-9280.2008.02225.x
   Brown SC, 2016, AM J PREV MED, V51, P78, DOI 10.1016/j.amepre.2016.02.008
   Browning MHEM, 2019, URBAN FOR URBAN GREE, V41, P23, DOI 10.1016/j.ufug.2019.03.002
   Burton EJ, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-839
   Casper Zhang, 2019, INT J ENV RES PUB HE, V16, P876
   Cherrie MPC, 2018, SOC SCI MED, V196, P56, DOI 10.1016/j.socscimed.2017.10.038
   Clark C, 2017, ENVIRON HEALTH PERSP, V125, DOI 10.1289/EHP1279
   Clarke P, 2009, MATURITAS, V64, P14, DOI 10.1016/j.maturitas.2009.07.011
   Clarke PJ, 2012, J EPIDEMIOL COMMUN H, V66, P730, DOI 10.1136/jech.2010.128116
   Massa KHC, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2016-011850
   Dalton AM, 2016, SSM-POPUL HLTH, V2, P683, DOI 10.1016/j.ssmph.2016.09.006
   Dalton AM, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-3833-z
   DANAHY DB, 2017, INT J OLDER PEOPLE N, V13, DOI DOI 10.1371/JOURNAL.PPAT.1006569
   de Keijzer C, 2019, ENVIRON INT, V122, P346, DOI 10.1016/j.envint.2018.11.046
   de Keijzer Carmen, 2016, Curr Environ Health Rep, V3, P468, DOI 10.1007/s40572-016-0116-x
   de Keijzer Carmen, 2018, ENVIRON HEALTH PERSP, V126
   de Vries S, 2003, ENVIRON PLANN A, V35, P1717, DOI 10.1068/a35111
   de Vries S, 2013, SOC SCI MED, V94, P26, DOI 10.1016/j.socscimed.2013.06.030
   DiPietro L, 2001, J GERONTOL A-BIOL, V56, P13, DOI 10.1093/gerona/56.suppl_2.13
   do Nascimento CF, 2018, J AGING HEALTH, V30, P118, DOI 10.1177/0898264316669229
   Dujardin C, 2014, HEALTH PLACE, V27, P59, DOI 10.1016/j.healthplace.2014.01.003
   Egorov AI, 2017, ENVIRON RES, V158, P508, DOI 10.1016/j.envres.2017.07.009
   Fielding RA, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0182155
   Gascon M, 2017, INT J HYG ENVIR HEAL, V220, P1207, DOI 10.1016/j.ijheh.2017.08.004
   Gascon M, 2016, ENVIRON INT, V86, P60, DOI 10.1016/j.envint.2015.10.013
   Gascon M, 2015, INT J ENV RES PUB HE, V12, P4354, DOI 10.3390/ijerph120404354
   Gascon M, 2013, ENVIRON INT, V52, P51, DOI 10.1016/j.envint.2012.11.005
   Gong Y, 2014, INT J BEHAV NUTR PHY, V11, DOI 10.1186/1479-5868-11-40
   Hartig T, 2014, ANNU REV PUBL HEALTH, V35, P207, DOI 10.1146/annurev-publhealth-032013-182443
   Helbich M, 2019, ENVIRON INT, V126, P107, DOI 10.1016/j.envint.2019.02.013
   Hilisdon M, 2006, PUBLIC HEALTH, V120, P1127, DOI 10.1016/j.puhe.2006.10.007
   Hong A, 2018, SOC SCI MED, V207, P38, DOI 10.1016/j.socscimed.2018.04.051
   Hyun Lee, 2019, INT J ENV RES PUB HE, V16, P789
   James P, 2017, EPIDEMIOLOGY, V28, P780, DOI [10.1097/EDE.0000000000000724, 10.1097/ede.0000000000000724]
   Jia XJ, 2018, ENVIRON RES, V167, P175, DOI 10.1016/j.envres.2018.07.003
   Kabisch N, 2017, ENVIRON RES, V159, P362, DOI 10.1016/j.envres.2017.08.004
   Kaplan R., 1995, EXPERIENCE NATURE PS
   KAPLAN S, 1995, J ENVIRON PSYCHOL, V15, P169, DOI 10.1016/0272-4944(95)90001-2
   King WC, 2005, AM J PREV MED, V28, P461, DOI 10.1016/j.amepre.2005.02.001
   Laatikainen TE, 2018, INT J HEALTH GEOGR, V17, DOI 10.1186/s12942-018-0149-5
   Lachowycz K, 2011, OBES REV, V12, pe183, DOI 10.1111/j.1467-789X.2010.00827.x
   Lara J, 2015, BMC MED, V13, DOI 10.1186/s12916-015-0470-9
   Lim K K, 2017, Prev Med Rep, V8, P116, DOI 10.1016/j.pmedr.2017.09.004
   Maas J, 2009, HEALTH PLACE, V15, P586, DOI 10.1016/j.healthplace.2008.09.006
   Markevych I, 2017, ENVIRON RES, V158, P301, DOI 10.1016/j.envres.2017.06.028
   McMurdo MET, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031878
   McPhee JS, 2016, BIOGERONTOLOGY, V17, P567, DOI 10.1007/s10522-016-9641-0
   Michael YL, 2014, SOC SCI MED, V102, P129, DOI 10.1016/j.socscimed.2013.11.047
   Mowen Andrew, 2007, J Phys Act Health, V4, P167
   Nagel CL, 2008, AM J EPIDEMIOL, V168, P461, DOI 10.1093/aje/kwn158
   Orban E, 2017, J URBAN HEALTH, V94, P158, DOI 10.1007/s11524-016-0112-3
   Ouzzani M, 2016, SYST REV-LONDON, V5, DOI 10.1186/s13643-016-0384-4
   Parra DC, 2010, SOC SCI MED, V70, P1070, DOI 10.1016/j.socscimed.2009.12.024
   Pearce J, 2018, T I BRIT GEOGR, V43, P555, DOI 10.1111/tran.12246
   Pun VC, 2018, ENVIRON HEALTH-GLOB, V17, DOI 10.1186/s12940-018-0381-2
   Reklaitiene R, 2014, SCAND J PUBLIC HEALT, V42, P669, DOI 10.1177/1403494814544494
   Ribeiro AI, 2015, BMC PUBLIC HEALTH, V15, DOI 10.1186/s12889-015-1879-y
   Richard Shaw, 2017, INT J ENV RES PUB HE, V14, P557
   Sarkar C, 2018, INT J HYG ENVIR HEAL, V221, P458, DOI 10.1016/j.ijheh.2018.01.009
   Sarkar C, 2018, LANCET PLANET HEALTH, V2, pE162, DOI [10.1016/S2542-5196(18)30051-2, 10.1016/s2542-5196(18)30051-2]
   Sarkar C, 2017, ENVIRON INT, V106, P1, DOI 10.1016/j.envint.2017.05.016
   Sarkar C, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-695
   Scott Brown, 2018, INT J ENV RES PUB HE, V15, P430
   Shin WH, 2011, LANDSCAPE URBAN PLAN, V103, P217, DOI 10.1016/j.landurbplan.2011.07.011
   Soga Masashi, 2017, Prev Med Rep, V5, P92
   Sorensen M, 2011, ENVIRON HEALTH-GLOB, V10, DOI 10.1186/1476-069X-10-92
   Tamosiunas A, 2014, ENVIRON HEALTH-GLOB, V13, DOI 10.1186/1476-069X-13-20
   Thornton CM, 2017, ANN BEHAV MED, V51, P159, DOI 10.1007/s12160-016-9837-1
   Twohig-Bennett C, 2018, ENVIRON RES, V166, P628, DOI 10.1016/j.envres.2018.06.030
   Tzivian L, 2016, ENVIRON HEALTH PERSP, V124, P1361, DOI 10.1289/ehp.1509824
   United Nations, 2017, WORLD POP AG 2017 HI
   Villeneuve PJ, 2018, ENVIRON RES, V160, P372, DOI 10.1016/j.envres.2017.10.005
   Visser M, 2002, J AM GERIATR SOC, V50, P1774, DOI 10.1046/j.1532-5415.2002.50504.x
   Vogt S, 2015, EUR J AGEING, V12, P273, DOI 10.1007/s10433-015-0345-0
   Wang D, 2013, ACT ADAPT AGING, V37, P153, DOI 10.1080/01924788.2013.784942
   Wang KF, 2019, J AM HEART ASSOC, V8, DOI [10.1161/JAHA.118.010258, 10.1161/jaha.118.010258]
   Wilson Lee-Ann M, 2011, Am J Health Promot, V25, pe12, DOI 10.4278/ajhp.090421-QUAN-144
   World Health Organization, 2015, Ageing and health
   Wu YT, 2017, AM J PREV MED, V53, P25, DOI 10.1016/j.amepre.2016.11.020
   Wu YT, 2015, AGE AGEING, V44, P1005, DOI 10.1093/ageing/afv137
   Wu YT, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2015-007936
   Xie B, 2018, SUSTAIN CITIES SOC, V43, P476, DOI 10.1016/j.scs.2018.09.010
   Yeh CY, 2018, J AGING SOC POLICY, V30, P72, DOI 10.1080/08959420.2017.1376844
   Yen IH, 2009, AM J PREV MED, V37, P455, DOI 10.1016/j.amepre.2009.06.022
   Yeo NL, 2020, GERONTOLOGIST, V60, pE184, DOI 10.1093/geront/gnz019
   Ying Z, 2015, J PHYS ACT HEALTH, V12, P569, DOI 10.1123/jpah.2013-0126
   Yu RB, 2018, J AM MED DIR ASSOC, V19, P528, DOI 10.1016/j.jamda.2017.12.015
   Zandieh R, 2017, INT J ENV RES PUB HE, V14, DOI 10.3390/ijerph14070740
NR 95
TC 82
Z9 84
U1 9
U2 121
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2196-5412
J9 CURR ENV HLTH REP
JI Curr.. Environ. Health Rep.
PD MAR
PY 2020
VL 7
IS 1
BP 65
EP 88
DI 10.1007/s40572-020-00264-7
PG 24
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA ME8LU
UT WOS:000544905600006
PM 31981136
DA 2025-06-11
ER

PT J
AU Liu, CC
   Li, Y
   Li, J
   Jin, CG
   Zhong, DP
AF Liu, Chengcheng
   Li, Yao
   Li, Jing
   Jin, Chenggang
   Zhong, Deping
TI The Effect of Psychological Burden on Dyslipidemia Moderated by
   Greenness: A Nationwide Study from China
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE chronic disease; dyslipidemia; depression; NDVI; middle-aged and older
   Chinese; multilevel mixed-effects logistic regression
ID RISK-FACTORS; DEPRESSIVE SYMPTOMS; NATURAL-ENVIRONMENT; METABOLIC
   SYNDROME; CHRONIC DISEASES; ELDERLY-PEOPLE; LIFE-STYLE; PREVALENCE;
   HEALTH; ADULTS
AB Globally, dyslipidemia is now become a leading risk factor for many adverse health outcomes, especially in the middle-aged and elderly. Recent evidence suggests that exposure to greenness and the relief of a psychological burden may decrease the prevalence of dyslipidemia. The objective of our study was to examine whether a green space can moderate the association between mental health status and dyslipidemia. Our study selected the datasets of depression symptoms, dyslipidemia from the China Health and Retirement Longitudinal Study (CHARLS), and the satellite-based normalized difference vegetation index (NDVI) from the 30 m annual maximum NDVI dataset in China in 2018. Ultimately, a total of 10,022 middle-aged and elderly Chinese were involved in our study. Multilevel logistic regressions were performed to examine the association between symptoms of depression and dyslipidemia, as well as the moderate effect of greenness exposure on the association. Our research suggested that adults diagnosed with depression symptoms were more likely to suffer from dyslipidemia. In addition, the NDVI was shown to moderate the effect of depression on dyslipidemia significantly, though the effect was attenuated as depression increased. Regarding the moderate effect of the NDVI on the above association across age, gender, and residence, the findings presented that females, the elderly, and respondents living in urban areas were at a greater risk of having dyslipidemia, although the protective effect of the NDVI was considered. Likewise, the moderate effect of the NDVI gradually decreased as the level of depression increased in different groups. The current study conducted in China provides insights into the association between mental health, green space, and dyslipidemia. Hence, improving mental health and green spaces can be potential targets for medical interventions to decrease the prevalence of dyslipidemia.
C1 [Liu, Chengcheng; Li, Yao; Jin, Chenggang] Beijing Normal Univ, Sch Social Dev & Publ Policy, Beijing 100875, Peoples R China.
   [Li, Jing] Beijing Normal Univ, Fac Geog Sci, Beijing 100875, Peoples R China.
   [Zhong, Deping] Minist Emergency Management Peoples Republ China, Natl Inst Nat Hazards, Beijing 100085, Peoples R China.
C3 Beijing Normal University; Beijing Normal University
RP Zhong, DP (corresponding author), Minist Emergency Management Peoples Republ China, Natl Inst Nat Hazards, Beijing 100085, Peoples R China.
EM ping_bnu@126.com
OI Liu, Chengcheng/0000-0002-4901-2075
CR Aitbaev KA, 2019, KARDIOLOGIYA, V59, P79, DOI 10.18087/cardio.2019.2.10231
   Akokuwebe ME, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19010125
   Al-Raddadi R, 2019, THER ADV CHRONIC DIS, V10, DOI 10.1177/2040622319878997
   An R., 2015, Int J Health Sci, P7, DOI [DOI 10.15640/IJHS.V3N3A2, 10.15640/ijhs.v3n3a2]
   Ancelin ML, 2010, BIOL PSYCHIAT, V68, P125, DOI 10.1016/j.biopsych.2010.04.011
   ANDA RF, 1990, JAMA-J AM MED ASSOC, V264, P1541, DOI 10.1001/jama.264.12.1541
   [Anonymous], 2007, Zhonghua Xin Xue Guan Bing Za Zhi
   Bonnell LN, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19116898
   Castro SL, 2002, LEADERSHIP QUART, V13, P69, DOI 10.1016/S1048-9843(01)00105-9
   Chen HJ, 2014, INT PSYCHOGERIATR, V26, P49, DOI 10.1017/S1041610213001701
   Cheng HG, 2016, J AFFECT DISORDERS, V195, P136, DOI 10.1016/j.jad.2016.02.023
   Chien JW, 2022, SCI TOTAL ENVIRON, V821, DOI 10.1016/j.scitotenv.2022.153526
   Cho SMJ, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-1189-y
   Chuang CS, 2014, GEN HOSP PSYCHIAT, V36, P497, DOI 10.1016/j.genhosppsych.2014.05.008
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cockerham WC, 2017, AM J PREV MED, V52, pS5, DOI 10.1016/j.amepre.2016.09.010
   Cohen J., 1988, STAT POWER ANAL BEHA, DOI [10.4324/9780203771587, DOI 10.4324/9780203771587]
   Cronbach LJ, 1951, PSYCHOMETRIKA, V16, P297
   Dadvand P, 2015, P NATL ACAD SCI USA, V112, P7937, DOI 10.1073/pnas.1503402112
   Donovan GH, 2019, HEALTH PLACE, V57, P305, DOI 10.1016/j.healthplace.2019.05.011
   Donovan GH, 2018, NAT PLANTS, V4, P358, DOI 10.1038/s41477-018-0151-8
   Dortland AKBV, 2013, PSYCHOSOM MED, V75, P83, DOI 10.1097/PSY.0b013e318274d30f
   Erem C, 2008, ENDOCRINE, V34, P36, DOI 10.1007/s12020-008-9100-z
   Fan J, 2020, ENVIRON INT, V144, DOI 10.1016/j.envint.2020.106042
   Fan SJ, 2020, ENVIRON INT, V142, DOI 10.1016/j.envint.2020.105903
   Fan ZY, 2021, INT J GEN MED, V14, P1449, DOI 10.2147/IJGM.S309783
   Gainey J, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0870-x
   Gallo LC, 2014, PSYCHOSOM MED, V76, P468, DOI 10.1097/PSY.0000000000000069
   Gao J, 2022, NUTR METAB CARDIOVAS, V32, P1138, DOI 10.1016/j.numecd.2022.01.020
   Gascon M, 2016, URBAN FOR URBAN GREE, V19, P88, DOI 10.1016/j.ufug.2016.07.001
   Gelman A, 2006, TECHNOMETRICS, V48, P432, DOI 10.1198/004017005000000661
   Gomez-Delgado F, 2021, CRIT REV FOOD SCI, V61, P1651, DOI 10.1080/10408398.2020.1764487
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Guo JH, 2022, ECOTOX ENVIRON SAFE, V231, DOI 10.1016/j.ecoenv.2022.113199
   Helbich M, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16050852
   Helbich M, 2019, ENVIRON INT, V126, P107, DOI 10.1016/j.envint.2019.02.013
   James Peter, 2015, Curr Epidemiol Rep, V2, P131
   Jiang CH, 2020, CURR MED SCI, V40, P858, DOI 10.1007/s11596-020-2270-5
   Jiang J, 2022, ENVIRON SCI POLLUT R, V29, P5852, DOI 10.1007/s11356-021-16026-3
   Joint committee issued Chinese guideline for the management of dyslipidemia in adults, 2016, Zhonghua Xin Xue Guan Bing Za Zhi, V44, P833, DOI 10.3760/cma.j.issn.0253-3758.2016.10.005
   Kargakou A, 2017, ADV EXP MED BIOL, V988, P49, DOI 10.1007/978-3-319-56246-9_4
   Karl T, 2010, SCIENCE, V330, P816, DOI 10.1126/science.1192534
   Kilim SR, 2013, J CLIN DIAGN RES, V7, P1596, DOI 10.7860/JCDR/2013/6162.3234
   Kim JA, 2020, DIABETES METAB J, V44, P307, DOI 10.4093/dmj.2019.0002
   Lee EY, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18041861
   Li L, 2022, FRONT PUBLIC HEALTH, V10, DOI 10.3389/fpubh.2022.878126
   Li YR, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0205709
   Liang Z, 2022, SCI TOTAL ENVIRON, V806, DOI 10.1016/j.scitotenv.2021.150628
   Liu HH, 2015, AGEING RES REV, V19, P43, DOI 10.1016/j.arr.2014.12.001
   Markevych I, 2017, ENVIRON RES, V158, P301, DOI 10.1016/j.envres.2017.06.028
   Mayhand KN, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18094398
   Mitchell R, 2008, LANCET, V372, P1655, DOI 10.1016/S0140-6736(08)61689-X
   Obasohan PE, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph182111234
   Obsa MS, 2022, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.778891
   Opoku S, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-89401-2
   Opoku S, 2019, BMC PUBLIC HEALTH, V19, DOI 10.1186/s12889-019-7827-5
   Patz JA, 2005, NATURE, V438, P310, DOI 10.1038/nature04188
   Penninx BWJH, 1998, HEALTH PSYCHOL, V17, P551, DOI 10.1037/0278-6133.17.6.551
   Pettorelli N, 2005, TRENDS ECOL EVOL, V20, P503, DOI 10.1016/j.tree.2005.05.011
   Qi L, 2015, INT J ENV RES PUB HE, V12, P13455, DOI 10.3390/ijerph121013455
   Rokni K, 2019, CATENA, V178, P59, DOI 10.1016/j.catena.2019.03.007
   Rouse J.W., 1974, P 3 EARTH RESOURCES, V1
   Sarkar C, 2018, LANCET PLANET HEALTH, V2, pE162, DOI [10.1016/S2542-5196(18)30051-2, 10.1016/s2542-5196(18)30051-2]
   Shanahan DF, 2015, BIOSCIENCE, V65, P476, DOI 10.1093/biosci/biv032
   Shi JK, 2018, CLIN CHIM ACTA, V486, P209, DOI 10.1016/j.cca.2018.08.001
   Sommet N, 2017, INT REV SOC PSYCHOL, V30, P203, DOI 10.5334/irsp.90
   Song PG, 2019, ATHEROSCLEROSIS, V282, P57, DOI 10.1016/j.atherosclerosis.2019.01.005
   Song PK, 2019, BIOMED ENVIRON SCI, V32, P559, DOI 10.3967/bes2019.074
   Soriano-Maldonado C, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph182312419
   Sun GZ, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-189
   Tang SL, 2022, BMC PUBLIC HEALTH, V22, DOI 10.1186/s12889-022-13309-3
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Wakabayashi I, 2010, J ATHEROSCLER THROMB, V17, P695, DOI 10.5551/jat.3517
   Wang P, 2019, HEALTH PLACE, V56, P184, DOI 10.1016/j.healthplace.2019.02.002
   Yang BY, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.17507
   Yang BY, 2019, ENVIRON POLLUT, V250, P14, DOI 10.1016/j.envpol.2019.03.128
   Yang BY, 2019, ENVIRON INT, V126, P727, DOI 10.1016/j.envint.2019.02.068
   Yang JL, 2019, REMOTE SENS ENVIRON, V233, DOI 10.1016/j.rse.2019.111395
   Yang Y, 2022, PUBLIC HEALTH NUTR, V25, P1233, DOI 10.1017/S1368980021004493
   Yitshak-Sade M, 2017, ENVIRON INT, V107, P147, DOI 10.1016/j.envint.2017.07.011
   Yu Y, 2021, GEOGR J, V187, P28, DOI 10.1111/geoj.12372
   Yue YF, 2022, HEALTH PLACE, V76, DOI 10.1016/j.healthplace.2022.102856
   Zegeye B, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18020750
   Zhou MG, 2016, LANCET, V387, P251, DOI 10.1016/S0140-6736(15)00551-6
NR 84
TC 3
Z9 3
U1 11
U2 52
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD NOV
PY 2022
VL 19
IS 21
AR 14287
DI 10.3390/ijerph192114287
PG 16
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 6F5WU
UT WOS:000884131500001
PM 36361165
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pradeep, C
   Sastha, KRP
   Kumar, SR
   Rathinisha, KU
   Kothai, R
   Arul, B
AF Pradeep, C.
   Sastha, K. R. Prasaath
   Kumar, S. Raj
   Rathinisha, K. U.
   Kothai, Ramalingam
   Arul, Balasubramanian
TI Prevalence of metabolic syndrome and its correlation with sexual
   dysfunction in adult psychiatric patients treated with psychotropics in
   a tertiary care hospital
SO INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
LA English
DT Article; Early Access
ID BIPOLAR DISORDER; SCHIZOPHRENIA; DEPRESSION; HEALTH; INPATIENTS; SUICIDE
AB Background: In the past two decades, there has been a profound increase in the incidence of metabolic disorders among the general population, and psychotropics are also said to play a major role in the development of metabolic syndrome.
   Aim: Determining the prevalence of metabolic syndrome (MetS) and sexual dysfunction (SD) and their correlation in psychiatric patients treated with psychotropics in a tertiary care hospital in Salem region, Tamil Nadu, India.
   Materials and Methods: A cross-sectional study was conducted in the psychiatric department of Vinayaka Mission's Medical College and Hospitals, Salem on patients (n = 108) treated with psychotropics. The sociodemographic information, anthropometric measurements, and laboratory tests for metabolic functions were collected and assessed to determine the presence of metabolic syndrome (as per NCEP ATP III criteria). All the results were statistically analysed and P-value < .05 was considered to be statistically significant.
   Results: The overall prevalence of MetS in the study population was 25.93%. The study found significant relationships between using olanzapine, risperidone, buspirone, and the presence of MetS. Depression was also found to be associated with the development of MetS.
   Conclusion: From this current study, it may be concluded that the psychiatric population is at risk for developing MetS, and the use of atypical antipsychotics (olanzapine, risperidone), anti-anxiety agent (buspirone) and clinical depression is significantly associated with metabolic syndrome. Hence, the metabolic function of psychiatric patients must be regularly assessed for early detection and management of any metabolic abnormalities. The study did not find a significant correlation between SD and MetS in psychiatric patients.
C1 [Pradeep, C.] Vinayaka Missions Res Fdn Deemed Univ, Dept Psychiat, Vinayaka Missions Kirupananda Variyar Med Coll &, Salem, India.
   [Sastha, K. R. Prasaath; Kumar, S. Raj; Rathinisha, K. U.; Kothai, Ramalingam; Arul, Balasubramanian] Vinayaka Missions Res Fdn Deemed Univ, Dept Pharm Practice, Vinayaka Missions Coll Pharm, Salem 636008, Tamil Nadu, India.
C3 Vinayaka Mission's Research Foundation; Vinayaka Mission's Kirupananda
   Variyar Medical College & Hospital; Vinayaka Mission's Research
   Foundation; Vinayaka Mission's College of Pharmacy
RP Arul, B (corresponding author), Vinayaka Missions Res Fdn Deemed Univ, Dept Pharm Practice, Vinayaka Missions Coll Pharm, Salem 636008, Tamil Nadu, India.
EM arul1971@gmail.com
RI Kumar, Sonu/GZA-9110-2022; Kothai, Ramalingam/ABF-4826-2020;
   Balasubramanian, Arul/P-6711-2015
OI Balasubramanian, Arul/0000-0001-6896-5069; , Prasaath
   Sastha/0000-0001-9353-3989
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alswat Khaled A, 2017, Med Arch, V71, P412, DOI 10.5455/medarh.2017.71.412-416
   Ansarimoghaddam A, 2018, DIABETES METAB SYND, V12, P195, DOI 10.1016/j.dsx.2017.11.004
   Chang HH, 2009, J AFFECT DISORDERS, V117, P124, DOI 10.1016/j.jad.2008.12.018
   Chesney E, 2014, WORLD PSYCHIATRY, V13, P153, DOI 10.1002/wps.20128
   Choong E, 2012, J PSYCHIATR RES, V46, P540, DOI 10.1016/j.jpsychires.2012.01.014
   Cornier MA, 2008, ENDOCR REV, V29, P777, DOI 10.1210/er.2008-0024
   Ebtekar F, 2018, DIABETES METAB SYND, V12, P955, DOI 10.1016/j.dsx.2018.06.002
   Gupta A, 2014, INDIAN J CLIN BIOCHE, V29, P196, DOI 10.1007/s12291-013-0415-z
   Heiskanen T, 2003, J CLIN PSYCHIAT, V64, P575, DOI 10.4088/JCP.v64n0513
   Hussain T, 2017, J CLIN DIAGN RES, V11, pVC05, DOI 10.7860/JCDR/2017/25801.10011
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Lieberman Joseph A 3rd, 2004, Prim Care Companion J Clin Psychiatry, V6, P8
   Malhotra N, 2013, J AFFECT DISORDERS, V150, P653, DOI 10.1016/j.jad.2013.03.010
   Mattoo SK, 2010, INDIAN J MED RES, V131, P46
   McCain Jack Alan, 2009, P T, V34, P355
   McGahuey CA, 2000, J SEX MARITAL THER, V26, P25, DOI 10.1080/009262300278623
   Medeiros-Ferreira L, 2013, ACTAS ESP PSIQUIATRI, V41, P17
   Milaneschi Y, 2020, BIOL PSYCHIAT, V88, P369, DOI 10.1016/j.biopsych.2020.01.014
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Organization WH, ICD-10: international statistical classification of diseases and related health problems: tenth revision Internet, V2nd
   Pallava A, 2012, NORD J PSYCHIAT, V66, P215, DOI 10.3109/08039488.2011.621977
   Teixeira PJR, 2007, REV BRAS PSIQUIATR, V29, P330, DOI 10.1590/S1516-44462007000400007
   Sahpolat M, 2021, NORD J PSYCHIAT, V75, P73, DOI 10.1080/08039488.2020.1815080
   Serafini G, 2017, FRONT PSYCHIATRY, V8, DOI 10.3389/fpsyt.2017.00149
   Serafini G, 2017, J AFFECT DISORDERS, V210, P249, DOI 10.1016/j.jad.2016.12.019
   Shojaeimotlagh V, 2019, DIABETES METAB SYND, V13, P143, DOI 10.1016/j.dsx.2018.08.014
   Sugawara N, 2010, SCHIZOPHR RES, V123, P244, DOI 10.1016/j.schres.2010.08.030
   Sun MJ, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17186700
   Tschoner A, 2007, INT J CLIN PRACT, V61, P1356, DOI 10.1111/j.1742-1241.2007.01416.x
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
NR 31
TC 3
Z9 3
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-5031
EI 1742-1241
J9 INT J CLIN PRACT
JI Int. J. Clin. Pract.
PD 2021 JUL 5
PY 2021
AR e14559
DI 10.1111/ijcp.14559
EA JUL 2021
PG 10
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA TE0LP
UT WOS:000669709900001
PM 34157190
DA 2025-06-11
ER

PT J
AU Brunero, S
   Lamont, S
AF Brunero, Scott
   Lamont, Scott
TI Systematic screening for metabolic syndrome in consumers with severe
   mental illness
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE metabolic syndrome; physical health; severe mental illness; screening
ID PHYSICAL HEALTH; GUIDELINES; MANAGEMENT; ANTIPSYCHOTICS; SCHIZOPHRENIA;
   PREVALENCE; CLOZAPINE; DISEASE; PEOPLE; TRIAL
AB The high prevalence of metabolic syndrome (MetS) in people with a mental illness has been reported recently in the literature. Gaps have emerged in the widespread use of systematic screening methods that identify this collection of critical risk factors for cardiac and metabolic disorders in people with severe mental illness. A sample (n = 103) of consumers with severe mental illness was screened for MetS using the Metabolic Syndrome Screening Tool and compared to a sample (n = 72) of consumers who were not receiving a systematic approach to screening for MetS. The results demonstrated ad hoc screening of consumers for MetS in the comparison group, potentially leaving patients at risk of cardiac and metabolic disorders being untreated. Mental health nurses are well placed to show leadership in the screening, treatment, and ongoing management of MetS in people with severe mental illness. A potential new speciality role entitled the 'cardiometabolic mental health nurse' is proposed as a means leading to improved outcomes for consumers who have both the complication of physical health problems and a severe mental illness.
C1 [Brunero, Scott] Prince Wales Hosp, Nurse Educ & Res Unit, Randwick, NSW 2031, Australia.
C3 University of New South Wales Sydney; Prince of Wales Hospital (POWH)
RP Brunero, S (corresponding author), Prince Wales Hosp, Nurse Educ & Res Unit, Edmund Blackett Bldg,Room 7,High St, Randwick, NSW 2031, Australia.
EM scott.brunero@sesiahs.health.nsw.gov.au
RI brunero, scott/X-5634-2018; Lamont, Scott/KEH-2123-2024
OI brunero, scott/0000-0003-4156-7014; Lamont, Scott/0000-0003-2497-1314
CR Ahmed M, 2008, IRISH J MED SCI, V177, P205, DOI 10.1007/s11845-008-0156-9
   *AM DIAB ASS, 2004, DIABETES CARE, V27, P396
   [Anonymous], 1968, 34 WHO
   Bowling A., 2002, RES METHODS HLTH, V2nd
   Braveman P, 1996, J PUBLIC HEALTH POL, V17, P14, DOI 10.2307/3342655
   BRUNERO S, 2009, ARCH PSYCHIAT NURSIN
   Connolly M., 2005, ADV PSYCHIAT TREATME, V11, P125, DOI [DOI 10.1192/APT.11.2.125, 10.1192/apt.11.2.125]
   *COUNC EUR, 1994, R94 COUNC EUR, P11
   De Hert M, 2006, INT CLIN PSYCHOPHARM, V21, pS11, DOI 10.1097/01.yic.0000201496.23259.85
   Elsom S, 2005, INT J MENT HEALTH NU, V14, P181, DOI 10.1111/j.1440-0979.2005.00379.x
   Emerson E, 2003, J INTELL DISABIL RES, V47, P51, DOI 10.1046/j.1365-2788.2003.00464.x
   GAFOOR M, 2001, J ADV NURS, V27, P497
   Gardner A, 2005, J ADV NURS, V49, P135, DOI 10.1111/j.1365-2648.2004.03273.x
   HANSON RL, 1995, DIABETES, V44, P418, DOI 10.2337/diabetes.44.4.418
   Hoffman L, 1998, MED J AUSTRALIA, V169, P93, DOI 10.5694/j.1326-5377.1998.tb140192.x
   Howard Patricia B, 2007, Issues Ment Health Nurs, V28, P255, DOI 10.1080/01612840601172593
   HUSSEINRASSOOL G, 2007, DUAL DIAGNOSIS NURSI
   International Diabetes Federation, 2007, WORLDW DEF MET SYNDR
   Katon W, 2001, GEN HOSP PSYCHIAT, V23, P138, DOI 10.1016/S0163-8343(01)00136-0
   Kousta Eleni, 2005, Hormones (Athens), V4, P133
   LAMBERT T, 2005, DIABETES PSYCHOTIC D
   Lamberti JS, 2006, AM J PSYCHIAT, V163, P1273, DOI 10.1176/appi.ajp.163.7.1273
   Llorente MD., 2006, CLIN DIABETES, V24, P18, DOI DOI 10.2337/DIACLIN.24.1.18
   Marder SR, 2004, AM J PSYCHIAT, V161, P1334, DOI 10.1176/appi.ajp.161.8.1334
   Muir-Cochrane E, 2005, CONT ISSUES RISK ASS
   Norris SL, 2002, AM J PREV MED, V22, P15, DOI 10.1016/S0749-3797(02)00423-3
   Oortwijn W, 2001, INT J TECHNOL ASSESS, V17, P269, DOI 10.1017/S026646230110601X
   Osborn DPJ, 2001, WESTERN J MED, V175, P329, DOI 10.1136/ewjm.175.5.329
   Phelan M., 2004, Journal of Mental Health, V13, P277, DOI DOI 10.1080/09638230410001700907
   Poulin MJ, 2005, CAN J PSYCHIAT, V50, P555, DOI 10.1177/070674370505000909
   Sacks FM, 2004, J CLIN PSYCHIAT, V65, P3
   Salsberry PJ, 2007, AM J PREV MED, V33, P114, DOI 10.1016/j.amepre.2007.03.017
   SHAW C, 1989, BRIT MED J, V19, P498
   Straker D, 2005, AM J PSYCHIAT, V162, P1217, DOI 10.1176/appi.ajp.162.6.1217
   Usher K, 2006, J PSYCHIATR MENT HLT, V13, P730, DOI 10.1111/j.1365-2850.2006.01026.x
   Wand T, 2008, INT J MENT HEALTH NU, V17, P363, DOI 10.1111/j.1447-0349.2008.00559.x
   Wright CE, 2007, INT J PSYCHOPHYSIOL, V63, P275, DOI 10.1016/j.ijpsycho.2006.11.005
   Wu RR, 2008, JAMA-J AM MED ASSOC, V299, P185, DOI 10.1001/jama.2007.56-b
   2003, BRIT J PSYCHIAT, V184, P112
NR 39
TC 57
Z9 61
U1 0
U2 11
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1445-8330
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD APR
PY 2009
VL 18
IS 2
BP 144
EP 150
DI 10.1111/j.1447-0349.2009.00595.x
PG 7
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 415WE
UT WOS:000263966300009
PM 19290978
DA 2025-06-11
ER

PT J
AU Mulvaney, SW
   Dineen, KJ
   Mahadevan, S
   Desronvilles, R Jr
   Olmsted, KLR
AF Mulvaney, Sean W.
   Dineen, Kyle J.
   Mahadevan, Sanjay
   Desronvilles Jr, Roosevelt
   Olmsted, Kristine L. Rae
TI Three-Month Durability of Bilateral Two-Level Stellate Ganglion Blocks
   in Patients with Generalized Anxiety Disorder: A Retrospective Analysis
SO BRAIN SCIENCES
LA English
DT Article
DE stellate ganglion; SGB; anxiety; generalized anxiety disorder; GAD-7;
   two-level cervical sympathetic chain block; 2LCSB; ultrasound
ID POSTTRAUMATIC-STRESS-DISORDER; METABOLIC SYNDROME; BRAIN; RESPONSES;
   SYMPTOMS; RETROPHARYNGEAL; DYSREGULATION; STIMULATION; DEPRESSION;
   MONOCYTES
AB Purpose: Determine if performing ultrasound-guided, bilateral, two-level cervical sympathetic chain blocks (2LCSB) (performed on subsequent days) provides durable improvement in symptoms associated with anxiety. Methods: A retrospective chart review was conducted between January 2022 and November 2024. We identified 114 patients who received bilateral, 2LCSB for anxiety symptoms. Generalized Anxiety Disorder 7-Item Scale (GAD-7) outcome measure scores were collected at baseline and three-months post procedure in 71 males and 43 females. Results: Out of 114 patients, 99 patients (86.8%) showed a long-lasting improvement in their GAD-7 scores. Collected GAD-7 forms had a baseline average of 15.52 (14.99 for males and 16.40 for females), which decreased after three months to an average of 7.28 (6.96 for males and 7.81 for females). This represents a 52% average improvement in anxiety symptoms. Conclusions: In individuals treated with bilateral, 2LCSB, GAD-related symptoms were improved by 52% for at least 3 months regardless of initial anxiety severity.
C1 [Mulvaney, Sean W.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
   [Dineen, Kyle J.; Mahadevan, Sanjay; Desronvilles Jr, Roosevelt] Orthobiol Res Initiat Inc, 11200 Rockville Pike 230, Bethesda, MD 20852 USA.
   [Olmsted, Kristine L. Rae] RTI Int, 3040 E Cornwallis Rd, Res Triangle Pk, NC 27709 USA.
C3 Uniformed Services University of the Health Sciences - USA; Research
   Triangle Institute
RP Dineen, KJ (corresponding author), Orthobiol Res Initiat Inc, 11200 Rockville Pike 230, Bethesda, MD 20852 USA.
EM seanmulvaney@hotmail.com; kyle@rosm.org; smahade3@alumni.jh.edu;
   roosevelt@rosm.org; krolmsted@rti.org
RI Mulvaney, Sean/NHP-1115-2025; Rae Olmsted, Kristine/AAU-3979-2020
OI , Kyle J Dineen/0009-0008-4599-0593; Desronvilles, Roosevelt
   J/0009-0001-7512-4038; Mulvaney, Sean/0000-0002-8762-2835; Rae Olmsted,
   Kristine/0000-0001-7432-1569; Mahadevan, Sanjay/0009-0007-2475-1019
CR Averill CL, 2020, BIOL PSYCHIAT-COGN N, V5, P135, DOI 10.1016/j.bpsc.2019.12.010
   Bandelow B, 2017, DIALOGUES CLIN NEURO, V19, P93
   Bandelow B, 2017, WORLD J BIOL PSYCHIA, V18, P162, DOI 10.1080/15622975.2016.1190867
   Bandelow B, 2016, WORLD J BIOL PSYCHIA, V17, P321, DOI 10.1080/15622975.2016.1181783
   Bhatia A, 2012, CAN J ANESTH, V59, P1040, DOI 10.1007/s12630-012-9779-4
   Brunyé TT, 2021, FRONT HUM NEUROSCI, V15, DOI 10.3389/fnhum.2021.625321
   Burback L, 2024, CURR NEUROPHARMACOL, V22, P557, DOI 10.2174/1570159X21666230428091433
   Bystritsky A, 2006, MOL PSYCHIATR, V11, P805, DOI 10.1038/sj.mp.4001852
   Chen HS, 2024, CLIN AUTON RES, V34, P45, DOI 10.1007/s10286-024-01019-2
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   D'Mello C, 2009, J NEUROSCI, V29, P2089, DOI 10.1523/JNEUROSCI.3567-08.2009
   Day TA, 2005, PROG NEURO-PSYCHOPH, V29, P1195, DOI 10.1016/j.pnpbp.2005.08.005
   de Craen AJM, 2000, J NEUROL, V247, P183, DOI 10.1007/s004150050560
   EDWARDS JG, 1981, DRUGS, V22, P495, DOI 10.2165/00003495-198122060-00005
   Felger JC, 2018, CURR NEUROPHARMACOL, V16, P533, DOI 10.2174/1570159X15666171123201142
   FLOR H, 1991, PAIN, V46, P145, DOI 10.1016/0304-3959(91)90069-A
   Garakani A, 2020, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.595584
   Gou Y., 2024, Biol Psychiatry
   Gyoneva S, 2014, GLIA, V62, P1345, DOI 10.1002/glia.22686
   Hendrickson RC, 2016, EXP NEUROL, V284, P181, DOI 10.1016/j.expneurol.2016.05.014
   Jnig W., 2022, The Integrative Action of the Autonomic Nervous System: Neurobiology of Homeostasis
   Kaplan GB, 2018, J NEUROTRAUM, V35, P210, DOI 10.1089/neu.2016.4953
   Kashiwagi M, 1999, Leg Med (Tokyo), V1, P262, DOI 10.1016/S1344-6223(99)80048-0
   KEMPWHEELER SM, 1987, BRIT J PSYCHOL, V78, P365, DOI 10.1111/j.2044-8295.1987.tb02254.x
   Kim EM, 2013, PAIN PHYSICIAN, V16, P117
   Kirkpatrick K, 2023, CUREUS J MED SCIENCE, V15, DOI 10.7759/cureus.35174
   Kupcova I, 2023, BMC PSYCHOL, V11, DOI 10.1186/s40359-023-01130-5
   Lambert E, 2010, J HYPERTENS, V28, P543, DOI 10.1097/HJH.0b013e3283350ea4
   LEBOVITS AH, 1990, CLIN J PAIN, V6, P153, DOI 10.1097/00002508-199006000-00015
   Li HT, 2022, P NATL ACAD SCI USA, V119, DOI 10.1073/pnas.2113518119
   Lipov EG, 2022, PAIN PHYSICIAN, V25, P77
   Liu Y, 2023, EUR REV MED PHARMACO, V27, P10233, DOI 10.26355/eurrev_202311_34298
   Lozano AM, 2019, NAT REV NEUROL, V15, P148, DOI 10.1038/s41582-018-0128-2
   Lynch JH, 2021, J INVEST MED, V69, P989, DOI 10.1136/jim-2020-001693
   Lynch JH, 2020, BRAIN BEHAV, V10, DOI 10.1002/brb3.1807
   Lynch JH, 2023, J PERS MED, V13, DOI 10.3390/jpm13060958
   McEwen BS, 2000, BIOL PSYCHIAT, V48, P721, DOI 10.1016/S0006-3223(00)00964-1
   Mehrotra M., 2023, Neuroanatomy, Stellate Ganglion
   Moore D C., 1954, Stellate Ganglion Block
   Morriss R, 2020, J AFFECT DISORDERS, V277, P785, DOI 10.1016/j.jad.2020.09.006
   Mulvaney S. W., 2020, J. Neurol. Disord, V7, P1
   Mulvaney SW, 2024, BRAIN SCI, V14, DOI 10.3390/brainsci14121193
   Mulvaney SW, 2024, MIL MED, DOI 10.1093/milmed/usae338
   Mulvaney SW, 2024, MIL MED, V189, pe2573, DOI 10.1093/milmed/usae193
   Mulvaney Sean W, 2015, J Spec Oper Med, V15, P79, DOI 10.55460/EQ05-H5TO
   Mulvaney SW, 2022, MIL MED, V187, pE826, DOI 10.1093/milmed/usab056
   Mulvaney SW, 2015, MIL MED, V180, pE601, DOI 10.7205/MILMED-D-14-00504
   Mulvaney SW, 2014, MIL MED, V179, P1133, DOI 10.7205/MILMED-D-14-00151
   Mulvaney SW, 2010, PAIN PRACT, V10, P359, DOI 10.1111/j.1533-2500.2010.00373.x
   Nance DM, 2007, BRAIN BEHAV IMMUN, V21, P736, DOI 10.1016/j.bbi.2007.03.008
   Narouze S, 2014, CURR PAIN HEADACHE R, V18, DOI 10.1007/s11916-014-0424-5
   Newman MG, 2022, EXPERT REV NEUROTHER, V22, P751, DOI 10.1080/14737175.2022.2125800
   Okuda Y, 2003, EUR J ANAESTH, V20, P757, DOI 10.1097/00003643-200309000-00016
   Park C, 2018, PAIN PHYSICIAN, V21, P9
   Patriquin Michelle A, 2017, Chronic Stress (Thousand Oaks), V1, DOI 10.1177/2470547017703993
   Peracoli MTS, 2003, MICROBES INFECT, V5, P413, DOI 10.1016/S1286-4579(03)00040-6
   Piraccini E., 2023, StatPearls
   Olmsted KRL, 2020, JAMA PSYCHIAT, V77, P130, DOI 10.1001/jamapsychiatry.2019.3474
   Rodriguez BF, 2006, J NERV MENT DIS, V194, P91, DOI 10.1097/01.nmd.0000198140.02154.32
   Roy-Byrne P, 2015, DIALOGUES CLIN NEURO, V17, P191
   Sapra A, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.8224
   Schore AN, 2002, AUST NZ J PSYCHIAT, V36, P9, DOI 10.1046/j.1440-1614.2002.00996.x
   Shapira NA, 2006, J NEUROL NEUROSUR PS, V77, P410, DOI 10.1136/jnnp.2005.069906
   Shekelle PG, 2018, ANN INTERN MED, V168, P414, DOI 10.7326/M17-1970
   Spitzer RL, 2006, ARCH INTERN MED, V166, P1092, DOI 10.1001/archinte.166.10.1092
   Takanami I, 2009, THORAC CARDIOV SURG, V57, P311, DOI 10.1055/s-2008-1038845
   ter Laan M, 2013, BRIT J ANAESTH, V111, P361, DOI 10.1093/bja/aet122
   Uchida T, 2015, J ANESTH, V29, P321, DOI 10.1007/s00540-014-1914-7
   van Amelsvoort T, 2016, FRONT PSYCHIATRY, V7, DOI 10.3389/fpsyt.2016.00082
   Wittling W, 1997, ACTA PHYSIOL SCAND, V161, P55
   Won E, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21186546
   Yang X, 2015, INT J CLIN EXP MED, V8, P15630
   Yang XR, 2021, EPIDEMIOL PSYCH SCI, V30, DOI 10.1017/S2045796021000275
   Yehuda R, 2009, ANN NY ACAD SCI, V1179, P56, DOI 10.1111/j.1749-6632.2009.04979.x
NR 74
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2076-3425
J9 BRAIN SCI
JI Brain Sci.
PD FEB
PY 2025
VL 15
IS 2
AR 188
DI 10.3390/brainsci15020188
PG 16
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA Y4B2V
UT WOS:001431592000001
PM 40002521
OA gold
DA 2025-06-11
ER

PT J
AU Adil, O
   Kuk, JL
   Ardern, CI
AF Adil, Omar
   Kuk, Jennifer L.
   Ardern, Chris I.
TI Associations between weight discrimination and metabolic health: A cross
   sectional analysis of middle aged adults
SO OBESITY RESEARCH & CLINICAL PRACTICE
LA English
DT Article
DE Weight discrimination; Diabetes; Metabolic syndrome; Obesity; Abdominal
   obesity; Weight stigma
ID OBESITY; STIGMA; INTERNALIZATION; OVERWEIGHT; STRESS; CARDIA; RISK; RACE
AB Background: Concurrent with the recent rise in overweight and obesity, concerns with weight discrimination have arisen. Individuals who have experienced weight discrimination report a host of deteriorations related to physical and psychological health, which may co-exist with behaviours such as increased food consumption and decreases in physical activity that make weight management difficult. What remains less clear, however, is the extent to which metabolic health may be specifically affected, and how this may vary by setting and perceived intensity of the lifetime history of weight discrimination.Method: To address this, a secondary data analysis was performed on 1365 participants from year 25 of the Coronary Artery Disease in Young Adults (CARDIA) study who were living with overweight and obesity. Descriptive statistics and logistic regression analyses were performed on the presence of metabolic syndrome, diabetes, and abdominal obesity, as well as their experience of the weight discrimination.Results: Prevalence of the metabolic syndrome, diabetes, and abdominal obesity was higher among those reporting low and high stress weight discrimination compared to those with no history of weight discrimination. In the adjusted analyses, weight discrimination was associated with a 65% greater likelihood for having meta-bolic syndrome, 85% greater likelihood of diabetes, and between a 2.5-and 3.9-times greater likelihood of abdominal obesity for low and high stress experiences, respectively.Conclusion: Exposure to weight discrimination may worsen metabolic health, as characterized by higher rates of metabolic syndrome and abdominal obesity. These associations may be greater with levels of stress experienced from weight discrimination. Further longitudinal work is necessary to understand the temporal sequence, time lag, and any possible critical periods for weight discrimination on metabolic health.
C1 [Adil, Omar; Kuk, Jennifer L.; Ardern, Chris I.] York Univ, Sch Kinesiol & Hlth Sci, 4700 Keele St, Toronto, ON M3J 1P3, Canada.
   [Adil, Omar] York Univ, Bethune Coll, Sch Kinesiol & Hlth Sci, 222A,4700 Keele St, Toronto, ON M3J 1P3, Canada.
C3 York University - Canada; York University - Canada
RP Adil, O (corresponding author), York Univ, Bethune Coll, Sch Kinesiol & Hlth Sci, 222A,4700 Keele St, Toronto, ON M3J 1P3, Canada.
EM adiloma1@yorku.ca; jennkuk@yorku.ca; cardern@yorku.ca
CR Adam TC, 2007, PHYSIOL BEHAV, V91, P449, DOI 10.1016/j.physbeh.2007.04.011
   Amer Diabet Assoc, 2014, DIABETES CARE, V37, pS14, DOI 10.2337/dc14-S014
   [Anonymous], 2010, ANTHROPOMETRY CARDIA
   [Anonymous], YEAR 25 2010 2011 MA
   Attie A. D., 2004, INT C SER, V1262, P220, DOI DOI 10.1016/J.ICS.2003.12.107
   Bastien M, 2014, PROG CARDIOVASC DIS, V56, P369, DOI 10.1016/j.pcad.2013.10.016
   Brown RE, 2015, OBES REV, V16, P77, DOI 10.1111/obr.12232
   CARDIA Study, CARDIA study year 25 exam protocol
   Chow LS, 2016, DIABETOLOGIA, V59, P1659, DOI 10.1007/s00125-016-3969-5
   Dutton GR, 2014, OBESITY, V22, P530, DOI 10.1002/oby.20438
   Foster GD, 1997, J CONSULT CLIN PSYCH, V65, P79, DOI 10.1037/0022-006X.65.1.79
   FRIEDMAN GD, 1988, J CLIN EPIDEMIOL, V41, P1105, DOI 10.1016/0895-4356(88)90080-7
   Gupta S, 2015, DIABET METAB SYND OB, V8, P327, DOI 10.2147/DMSO.S83696
   Hansson LM, 2010, SCAND J PUBLIC HEALT, V38, P587, DOI 10.1177/1403494810372266
   Harriger JA, 2010, SEX ROLES, V63, P609, DOI 10.1007/s11199-010-9868-1
   Herman WH, 2012, J CLIN ENDOCR METAB, V97, P1067, DOI 10.1210/jc.2011-1894
   Major B, 2012, SOC PSYCHOL PERS SCI, V3, P651, DOI 10.1177/1948550611434400
   Miranda PJ, 2005, AM HEART J, V149, P33, DOI 10.1016/j.ahj.2004.07.013
   Muennig P, 2008, BMC PUBLIC HEALTH, V8, DOI 10.1186/1471-2458-8-128
   Panza GA, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0217623
   Pearl RL, 2018, OBES REV, V19, P1141, DOI 10.1111/obr.12701
   Pearl RL, 2017, OBESITY, V25, P317, DOI 10.1002/oby.21716
   Puhl RM, 2008, INT J OBESITY, V32, P992, DOI 10.1038/ijo.2008.22
   Puhl RM, 2010, AM J PUBLIC HEALTH, V100, P1019, DOI 10.2105/AJPH.2009.159491
   Schmitz KH, 2000, INT J OBESITY, V24, P1475, DOI 10.1038/sj.ijo.0801415
   Sutin AR, 2015, PSYCHOL SCI, V26, P1803, DOI 10.1177/0956797615601103
   Sutin AR, 2014, OBESITY, V22, P1959, DOI 10.1002/oby.20789
   Sutin AR, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0070048
   Tomiyama AJ, 2014, APPETITE, V82, P8, DOI 10.1016/j.appet.2014.06.108
   Tomiyama AJ, 2014, HEALTH PSYCHOL, V33, P862, DOI 10.1037/hea0000107
   Tsenkova VK, 2011, ANN BEHAV MED, V41, P243, DOI 10.1007/s12160-010-9238-9
   Udo T, 2016, INT J CLIN PRACT, V70, P1003, DOI 10.1111/ijcp.12902
   Wu YK, 2018, J ADV NURS, V74, P1030, DOI 10.1111/jan.13511
   Zhang C, 2008, CIRCULATION, V117, P1658, DOI 10.1161/CIRCULATIONAHA.107.739714
NR 34
TC 6
Z9 6
U1 0
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-403X
EI 1878-0318
J9 OBES RES CLIN PRACT
JI Obes. Res. Clin. Pract.
PD MAR-APR
PY 2022
VL 16
IS 2
BP 151
EP 157
DI 10.1016/j.orcp.2022.02.006
EA APR 2022
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 1T5YT
UT WOS:000804804800008
PM 35227638
DA 2025-06-11
ER

PT J
AU Maki, M
   Bjorklund, P
AF Maki, Melissa
   Bjorklund, Pamela
TI Improving Cardiovascular Disease Screening in Community Mental Health
   Centers
SO PERSPECTIVES IN PSYCHIATRIC CARE
LA English
DT Article
DE Cardiometabolic risk; cardiovascular disease (CVD) screening; process
   improvement
ID ANTIPSYCHOTICS
AB PURPOSE: Increased mortality among the seriously mentally ill is largely due to cardiovascular disease (CVD). This applied research project examined a process of CVD screening at a community mental health center, then implemented and evaluated an improved process of identifying and managing CVD risk factors. DESIGN AND METHODS: Patient records (n= 130) were reviewed at baseline and 6 months posteducational intervention and implementation of new monitoring tools. FINDINGS: Statistical analysis showed significant process improvement (p < .001). PRACTICE IMPLICATIONS: Advanced practice registered nurses can design and implement improved CVD screening to mitigate morbidity and mortality in the seriously mentally ill.
C1 [Maki, Melissa] Ctr Human Dev, Duluth, MN USA.
   [Bjorklund, Pamela] Coll St Scholastica, Dept Grad Nursing, Duluth, MN USA.
C3 College of St. Scholastica
RP Maki, M (corresponding author), Ctr Human Dev, Duluth, MN USA.
EM mmaki@css.edu
CR [Anonymous], 2006, PREVENTING CHRONIC D
   Baker Donna L, 2002, AORN J, V75, P825, DOI 10.1016/S0001-2092(06)61639-6
   Barnes TRE, 2007, SCHIZOPHRENIA BULL, V33, P1397, DOI 10.1093/schbul/sbm038
   Buckley PF, 2005, SCHIZOPHR RES, V79, P281, DOI 10.1016/j.schres.2005.04.010
   Chen Y.-H., 2010, SCHIZOPHRENIA B, V37, P1
   Citrome Leslie, 2005, J Psychopharmacol, V19, P102, DOI 10.1177/0269881105059505
   Correll CU, 2007, SCHIZOPHR RES, V92, P103, DOI 10.1016/j.schres.2007.01.004
   Correll Christoph U, 2010, Psychiatr Serv, V61, P892, DOI 10.1176/ps.2010.61.9.892
   Dianis NL, 1998, J NURS CARE QUAL, V12, P49, DOI 10.1097/00001786-199804000-00011
   Goff DC, 2005, SCHIZOPHR RES, V80, P45, DOI 10.1016/j.schres.2005.08.010
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   *JOINT COMM ACCR H, 1994, FRAM IMPR PERF PRINC
   Merritt B.O., 2003, FOCUS PDCA STRATEGY
   Nasrallah HA, 2006, SCHIZOPHR RES, V86, P15, DOI 10.1016/j.schres.2006.06.026
   Newcomer John W, 2004, J Clin Psychopharmacol, V24, pS1, DOI 10.1097/01.jcp.0000142281.85207.d5
   Parks J., 2006, MOBIDITY MORTALITY P
   Ramsey C., 2000, HEALTHC FINANC MANAG, V54, P2
   Redick E L, 1999, Dimens Crit Care Nurs, V18, P30, DOI 10.1097/00003465-199911000-00005
NR 18
TC 12
Z9 13
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0031-5990
EI 1744-6163
J9 PERSPECT PSYCHIATR C
JI Perspect. Psychiatr. Care
PD JUL
PY 2013
VL 49
IS 3
BP 179
EP 186
DI 10.1111/j.1744-6163.2012.00348.x
PG 8
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 175AR
UT WOS:000321202000006
PM 23819668
DA 2025-06-11
ER

PT J
AU Byrne, ME
   Tanofsky-Kraff, M
   Kelly, NR
   Grammer, AC
   Jaramillo, M
   Mi, SJ
   Stojek, MM
   Shank, LM
   Burke, NL
   Cassidy, O
   Schvey, NA
   Brady, SM
   Demidowich, AP
   Broadney, MM
   Yanovski, SZ
   Yanovski, JA
AF Byrne, Meghan E.
   Tanofsky-Kraff, Marian
   Kelly, Nichole R.
   Grammer, Anne Claire
   Jaramillo, Manuela
   Mi, Sarah J.
   Stojek, Monika M.
   Shank, Lisa M.
   Burke, Natasha L.
   Cassidy, Omni
   Schvey, Natasha A.
   Brady, Sheila M.
   Demidowich, Andrew P.
   Broadney, Miranda M.
   Yanovski, Susan Z.
   Yanovski, Jack A.
TI Pediatric Loss-of-Control Eating and Anxiety in Relation to Components
   of Metabolic Syndrome
SO JOURNAL OF PEDIATRIC PSYCHOLOGY
LA English
DT Article
DE anxiety; loss of control eating; metabolic syndrome; obesity; pediatrics
ID WEIGHT-GAIN; MEAL INTAKE; HIGH-RISK; CHILDREN; BINGE; OVERWEIGHT;
   ADOLESCENTS; BEHAVIORS; STRESS; MAINTENANCE
AB Objective Pediatric loss-of-control (LOC) eating is associated with, and predictive of, gains in adiposity and adverse metabolic outcomes. In addition, some preliminary data suggest that anxiety may exacerbate the relationship of LOC eating with weight and metabolic syndrome (MetS)-related measures. We therefore examined whether anxiety moderated the relationship between LOC eating and body mass index z (BMIz), adiposity, and MetS-related measures in youth. Methods A convenience sample of non-treatment-seeking boys and girls of varying weight strata were interviewed to determine the presence of LOC eating and completed a questionnaire assessing trait anxiety. BMIz and MetS-related measures (blood pressure, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, glucose, and insulin) were measured after an overnight fast. Adiposity was assessed by air displacement plethysmography or dual-energy x-ray absorptiometry. Analyses adjusted for age, sex, race, height, fat mass, and depressive symptoms, as appropriate. Results In all, 379 youths (13.0 +/- 2.8 years; 53% female; BMIz = 0.8 +/- 1.1; 22% with LOC eating) were studied. Anxiety was not significantly related to BMIz, adiposity, or MetS-related measures. However, anxiety and LOC eating interacted such that only among youth with LOC eating, anxiety was positively associated with fasting insulin (p = .02) and insulin resistance (p = .01). The interaction of anxiety and LOC eating was not significantly related to BMIz, adiposity, or any other MetS-related measure (ps = ns). Conclusions Only among non-treatment-seeking youth with LOC eating, anxiety may be associated with increased insulin secretion and insulin resistance. Longitudinal studies are required to confirm these findings and explore mechanisms for these relationships.
C1 [Byrne, Meghan E.; Tanofsky-Kraff, Marian; Kelly, Nichole R.; Jaramillo, Manuela; Stojek, Monika M.; Shank, Lisa M.; Burke, Natasha L.; Cassidy, Omni; Schvey, Natasha A.] USUHS, Dept Med & Clin Psychol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
   [Byrne, Meghan E.; Tanofsky-Kraff, Marian; Kelly, Nichole R.; Grammer, Anne Claire; Jaramillo, Manuela; Mi, Sarah J.; Stojek, Monika M.; Shank, Lisa M.; Burke, Natasha L.; Cassidy, Omni; Schvey, Natasha A.; Brady, Sheila M.; Demidowich, Andrew P.; Broadney, Miranda M.; Yanovski, Jack A.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Growth & Obes, Program Endocrinol Metab & Genet, Div Intramural Res,NIH,DHHS, Bethesda, MD USA.
   [Shank, Lisa M.] Henry M Jackson Fdn Adv Mil Med HJF, Bethesda, MD USA.
   [Yanovski, Susan Z.] NIDDK, Div Digest Dis & Nutr, NIH, DHHS, Bethesda, MD 20892 USA.
   [Kelly, Nichole R.] Univ Oregon, Counseling Psychol & Human Serv, Eugene, OR 97403 USA.
   [Stojek, Monika M.] Emory Univ, Sch Med, Dept Psychiat, Atlanta, GA 30322 USA.
C3 National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver
   National Institute of Child Health & Human Development (NICHD); Division
   of Intramural Research (DIR); Henry M. Jackson Foundation for the
   Advancement of Military Medicine, Inc; National Institutes of Health
   (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney
   Diseases (NIDDK); University of Oregon; Emory University
RP Tanofsky-Kraff, M (corresponding author), USUHS, Dept Med & Clin Psychol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM marian.tanofsky-kraff@usuhs.edu
RI Stojek, Monika/AAB-5990-2021; Burke, Natasha/AAY-2110-2020; Shank,
   Lisa/I-7079-2015
OI Byrne, Meghan/0000-0002-4745-649X; Burke, Natasha/0000-0001-9347-0156;
   Shank, Lisa/0000-0002-6922-7946; Kelly, Nichole/0000-0003-0812-4182;
   Yanovski, Jack/0000-0001-8542-1637; Stojek, Monika/0000-0003-3777-8054
FU Uniformed Services University of the Health Sciences grant [R072IC];
   Intramural Research Program, National Institutes of Health from the
   National Institute of Child Health and Human Development [1ZIAHD000641];
   National Institute of Child Health and Human Development; National
   Institute on Minority Health and Health Disparities; National Institutes
   of Health Clinical Center Bench to Bedside Program; Office of Behavioral
   and Social Sciences Research (OBSSR) of the NIH
FX This work was supported by the Uniformed Services University of the
   Health Sciences grant R072IC (to M.T.K.); Intramural Research Program,
   National Institutes of Health, grant 1ZIAHD000641 from the National
   Institute of Child Health and Human Development with supplemental
   funding from National Institute on Minority Health and Health
   Disparities; the National Institutes of Health Clinical Center Bench to
   Bedside Program; and the Office of Behavioral and Social Sciences
   Research (OBSSR) of the NIH (to J.A.Y.)
CR Agras WS, 1998, BEHAV THER, V29, P491, DOI 10.1016/S0005-7894(98)80045-2
   Aspen V, 2014, EAT BEHAV, V15, P686, DOI 10.1016/j.eatbeh.2014.08.023
   Behrens JT, 1997, PSYCHOL METHODS, V2, P131, DOI 10.1037/1082-989X.2.2.131
   BryantWaugh RJ, 1996, INT J EAT DISORDER, V19, P391, DOI 10.1002/(SICI)1098-108X(199605)19:4<391::AID-EAT6>3.0.CO;2-G
   Burke NL, 2015, J DEV BEHAV PEDIATR, V36, P133, DOI 10.1097/DBP.0000000000000143
   Charmandari E, 2003, HORM RES, V59, P161, DOI 10.1159/000069325
   Chrousos G, 2000, INT J OBESITY RELATE, V24
   Epel E, 2004, ANN NY ACAD SCI, V1032, P208, DOI 10.1196/annals.1314.022
   Fairburn Christopher G., 1993, P317
   Glasofer DR, 2007, J PEDIATR PSYCHOL, V32, P95, DOI 10.1093/jpepsy/jsl012
   Goldschmidt AB, 2008, INT J EAT DISORDER, V41, P153, DOI 10.1002/eat.20481
   Goodman E, 2002, PEDIATRICS, V110, P497, DOI 10.1542/peds.110.3.497
   Goossens L, 2009, EUR EAT DISORD REV, V17, P68, DOI 10.1002/erv.892
   Goran MI, 2001, DIABETES, V50, P2444, DOI 10.2337/diabetes.50.11.2444
   Guyer AE, 2014, DEV PSYCHOPATHOL, V26, P229, DOI 10.1017/S0954579413000941
   He JB, 2017, INT J EAT DISORDER, V50, P91, DOI 10.1002/eat.22661
   HEATHERTON TF, 1991, PSYCHOL BULL, V110, P86, DOI 10.1037/0033-2909.110.1.86
   Hilbert A, 2013, J ABNORM PSYCHOL, V122, P684, DOI 10.1037/a0033330
   Hilbert A, 2009, BEHAV RES THER, V47, P26, DOI 10.1016/j.brat.2008.10.003
   Hollingshead A., 2011, Four factor index of social status, V8, P21
   Hudson JI, 2010, AM J CLIN NUTR, V91, P1568, DOI 10.3945/ajcn.2010.29203
   Jarcho JM, 2015, NEUROIMAGE, V108, P343, DOI 10.1016/j.neuroimage.2014.12.054
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kenardy J, 1996, AUST NZ J PSYCHIAT, V30, P839, DOI 10.3109/00048679609065053
   Kovacs M., 1977, DEPRESSION CHILDHOOD, P1
   Kuczmarski RJ, 2002, Advance Data, V11, P1
   Micali N, 2015, J AM ACAD CHILD PSY, V54, P652, DOI 10.1016/j.jaac.2015.05.009
   Moran A, 1999, DIABETES, V48, P2039, DOI 10.2337/diabetes.48.10.2039
   Nicholson JC, 2001, PEDIATR RES, V50, P467, DOI 10.1203/00006450-200110000-00008
   Pallister E, 2008, CLIN PSYCHOL REV, V28, P366, DOI 10.1016/j.cpr.2007.07.001
   PAPAY JP, 1978, J ABNORM CHILD PSYCH, V6, P115, DOI 10.1007/BF00915787
   Radin RM, 2015, EAT BEHAV, V19, P86, DOI 10.1016/j.eatbeh.2015.07.002
   Ranzenhofer LM, 2013, APPETITE, V68, P30, DOI 10.1016/j.appet.2013.03.018
   Rosmond R, 2005, PSYCHONEUROENDOCRINO, V30, P1, DOI 10.1016/j.psyneuen.2004.05.007
   Schlüter N, 2016, INT J EAT DISORDER, V49, P413, DOI 10.1002/eat.22488
   Seligman L D, 1998, Clin Child Fam Psychol Rev, V1, P125, DOI 10.1023/A:1021887712873
   Shank LM, 2017, COMPR PSYCHIAT, V76, P36, DOI 10.1016/j.comppsych.2017.03.015
   Shomaker LB, 2010, INT J EAT DISORDER, V43, P707, DOI 10.1002/eat.20767
   Shomaker LB, 2010, PEDIATR DIABETES, V11, P417, DOI 10.1111/j.1399-5448.2009.00606.x
   Spielberger C.D., 1983, Manual for the State-Trait Anxiety Inventory
   Spielberger C. D., 1972, ANXIETY CURRENT TREN, P22
   Stice E, 1998, BEHAV THER, V29, P257, DOI 10.1016/S0005-7894(98)80006-3
   Stice E, 2002, PSYCHOL BULL, V128, P825, DOI 10.1037//0033-2909.128.5.825
   Stiensmeier-Pelster J., 2000, Depressions-Inventar Fur Kinder und Jugendliche
   Tanofsky-Kraff M, 2004, J CONSULT CLIN PSYCH, V72, P53, DOI 10.1037/0022-006X.72.1.53
   Tanofsky-Kraff M, 2012, INT J OBESITY, V36, P956, DOI 10.1038/ijo.2011.259
   Tanofsky-Kraff Marian, 2008, Eat Behav, V9, P360, DOI 10.1016/j.eatbeh.2008.03.002
   Tanofsky-Kraff M, 2009, INT J EAT DISORDER, V42, P26, DOI 10.1002/eat.20580
   Tanofsky-Kraff M, 2007, J CONSULT CLIN PSYCH, V75, P901, DOI 10.1037/0022-006X.75.6.901
   Tanofsky-Kraff M, 2017, J CONSULT CLIN PSYCH, V85, P218, DOI 10.1037/ccp0000153
   Tanofsky-Kraff M, 2011, J ABNORM PSYCHOL, V120, P108, DOI 10.1037/a0021406
   TAYLOR AL, 1988, NEW ENGL J MED, V319, P213, DOI 10.1056/NEJM198807283190405
   Weir GC, 2004, DIABETES, V53, pS16, DOI 10.2337/diabetes.53.suppl_3.S16
   Weiss Ram, 2006, Curr Diab Rep, V6, P182, DOI 10.1007/s11892-006-0032-9
   Zimmet P, 2007, PEDIATR DIABETES, V8, P299, DOI 10.1111/j.1399-5448.2007.00271.x
   2008, APPETITE, V50, P223, DOI DOI 10.1016/J.APPET.2007.07.004
NR 56
TC 19
Z9 19
U1 1
U2 16
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0146-8693
EI 1465-735X
J9 J PEDIATR PSYCHOL
JI J. Pediatr. Psychol.
PD MAR
PY 2019
VL 44
IS 2
BP 220
EP 228
DI 10.1093/jpepsy/jsy077
PG 9
WC Psychology, Developmental
WE Social Science Citation Index (SSCI)
SC Psychology
GA HY1VC
UT WOS:000467904200009
PM 30339233
OA Green Published
DA 2025-06-11
ER

PT J
AU Fung, ACH
   Tse, G
   Cheng, HL
   Lau, ESH
   Luk, A
   Ozaki, R
   So, TTY
   Wong, RYM
   Tsoh, J
   Chow, E
   Wing, YK
   Chan, JCN
   Kong, APS
AF Fung, Annie C. H.
   Tse, Gary
   Cheng, Hiu Lam
   Lau, Eric S. H.
   Luk, Andrea
   Ozaki, Risa
   So, Tammy T. Y.
   Wong, Rebecca Y. M.
   Tsoh, Joshua
   Chow, Elaine
   Wing, Yun Kwok
   Chan, Juliana C. N.
   Kong, Alice P. S.
TI Depressive Symptoms, Co-Morbidities, and Glycemic Control in Hong Kong
   Chinese Elderly Patients With Type 2 Diabetes Mellitus
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE diabetes; depression; elderly; GDS-15; hypoglycaemia; comorbidities
ID EVALUATION JADE PROGRAM; OLDER-ADULTS; CARDIOVASCULAR-DISEASE;
   MEDICATION ADHERENCE; OXIDATIVE STRESS; MAJOR DEPRESSION; METAANALYSIS;
   RISK; ASSOCIATION; PREVALENCE
AB Background and objectives: Undiagnosed depression is an important comorbidity in type 2 diabetes (T2D) which can be detected using the Geriatric Depression Scale (GDS-15) questionnaire. In this cross-sectional study, we examined the associations of depression using GDS score with control of cardiometabolic risk factors and health status in elderly patients with T2D.
   Setting and participants: Between February and December 2013, patients aged >= 65 years who underwent structured comprehensive assessment as a quality improvement program at the Diabetes Center of a teaching hospital were invited to complete the GDS-15 questionnaire.
   Main outcome measures: Depression was defined as a GDS score >= 7. Demographic data, prior history of co-morbidities, frequency of self-reported hypoglycemia, and attainment of treatment targets defined as HbA(1c), <7%, blood pressure <130/80 mmHg, and LDL-C <2.6 mmol/L were documented.
   Results: Among 325 participants (65% male, median [interquartile range] age: 69 [8] years), 42 (13%) had depression. Patients with depression had longer disease durations (mean +/- SD: 15.1 +/- 9.1 vs. 11.6 +/- 8.1 years, P = 0.02), more frequent self-reported hypoglycemic events (17 vs. 6%, P = 0.03) and were less likely to attain all three treatment targets (0 vs. 16%, P = 0.004) than those without depression. On multivariable analysis, patients with depression had an odds ratio of 2.84 (95% confidence intervals: 1.35-6.00, P = 0.006) of reporting prior history of co-morbidities.
   Conclusion: In elderly patients with T2D, depression was not uncommon especially in those with poor control of risk factors, hypoglycemia, and co-morbidities. Inclusion of GDS-15 questionnaire during structured assessment for complications and risk factors can identify these high-risk patients for more holistic management of their physical and mental health.
C1 [Fung, Annie C. H.; Tse, Gary; Lau, Eric S. H.; Luk, Andrea; Ozaki, Risa; So, Tammy T. Y.; Wong, Rebecca Y. M.; Chow, Elaine; Chan, Juliana C. N.; Kong, Alice P. S.] Chinese Univ Hong Kong, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China.
   [Tse, Gary; Luk, Andrea; Chan, Juliana C. N.; Kong, Alice P. S.] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Shatin, Hong Kong, Peoples R China.
   [Cheng, Hiu Lam; Tsoh, Joshua] Chinese Univ Hong Kong, Sch Publ Hlth & Primary Care, Shatin, Hong Kong, Peoples R China.
   [Luk, Andrea; Chan, Juliana C. N.; Kong, Alice P. S.] Chinese Univ Hong Kong, Hong Kong Inst Diabet & Obes, Shatin, Hong Kong, Peoples R China.
   [Wing, Yun Kwok] Chinese Univ Hong Kong, Dept Psychiat, Shatin, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong; Chinese University of Hong Kong;
   Chinese University of Hong Kong; Chinese University of Hong Kong;
   Chinese University of Hong Kong
RP Kong, APS (corresponding author), Chinese Univ Hong Kong, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China.; Kong, APS (corresponding author), Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Shatin, Hong Kong, Peoples R China.; Kong, APS (corresponding author), Chinese Univ Hong Kong, Hong Kong Inst Diabet & Obes, Shatin, Hong Kong, Peoples R China.
EM alicekong@cuhk.edu.hk
RI Kong, Alice/P-3703-2015; Luk, Andrea/B-5766-2016; Wing, Y./H-9691-2019;
   Lau, Eric S.H./AGZ-2920-2022; Chow, Elaine/HJB-2197-2022; Chan,
   Juliana/B-7918-2016
OI Wing, Yun kwok/0000-0002-5745-5474; TSOH, Joshua/0000-0001-9001-5158;
   Chow, Elaine/0000-0002-4147-3387; Fung, Annie/0000-0001-6688-904X; Lau,
   Eric S. H./0000-0003-1581-5643; Chan, Juliana/0000-0003-1325-1194; Kong,
   Alice/0000-0001-8927-6764
FU Croucher Foundation of Hong Kong
FX We thank the medical and nursing staff at the Prince of Wales Hospital
   Diabetes Centre for their help in recruitment of subjects for this
   study. GT is supported by a Research Fellowship from the Croucher
   Foundation of Hong Kong.
CR Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   Boey KW, 2005, AGING MENT HEALTH, V9, P555, DOI 10.1080/13607860500193351
   Bogner HR, 2007, DIABETES CARE, V30, P3005, DOI 10.2337/dc07-0974
   Bogner HR, 2012, ANN FAM MED, V10, P15, DOI 10.1370/afm.1344
   Chan ACM, 1996, J AGING HEALTH, V8, P238, DOI 10.1177/089826439600800205
   Chan J, 2009, DIABETIC MED, V26, P693, DOI 10.1111/j.1464-5491.2009.02751.x
   Chan JCN, 2014, DIABETES RES CLIN PR, V106, pS295, DOI 10.1016/S0168-8227(14)70733-8
   Chan JCN, 2011, CURR CARDIOVASC RISK, V5, P230, DOI 10.1007/s12170-011-0172-6
   Chan SWC, 2009, INT PSYCHOGERIATR, V21, P1171, DOI 10.1017/S1041610209990950
   Chau Janita, 2006, Psychol Health Med, V11, P48, DOI 10.1080/13548500500093688
   Chau PH, 2011, J NUTR HEALTH AGING, V15, P751, DOI 10.1007/s12603-011-0071-z
   Cheng ST, 2010, AM J GERIAT PSYCHIAT, V18, P256, DOI 10.1097/JGP.0b013e3181bf9edd
   Chi I, 2005, AM J GERIAT PSYCHIAT, V13, P409, DOI 10.1176/appi.ajgp.13.5.409
   de Groot M, 2001, PSYCHOSOM MED, V63, P619, DOI 10.1097/00006842-200107000-00015
   Egede LE, 2004, DIABETES CARE, V27, P421, DOI 10.2337/diacare.27.2.421
   Kong APS, 2007, DIABETES CARE, V30, P953, DOI 10.2337/dc06-2443
   Lee H.-C., 1993, CLIN GERONTOLOGIST, V14, P37
   Leung DYP, 2015, GERIATR GERONTOL INT, V15, P789, DOI 10.1111/ggi.12342
   Lou VWQ, 2013, AGE AGEING, V42, P215, DOI 10.1093/ageing/afs159
   Luk AOY, 2017, DIABETES CARE, V40, P928, DOI 10.2337/dc16-2354
   Luk AOY, 2013, DIABETES-METAB RES, V29, P384, DOI 10.1002/dmrr.2404
   Michel TM, 2012, CURR PHARM DESIGN, V18, P5890
   Monnier L, 2009, DIABETES CARE, V32, pS199, DOI 10.2337/dc09-S310
   Moreira BD, 2016, BMC GERIATR, V16, DOI 10.1186/s12877-016-0234-1
   Nan HR, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-198
   Nouwen A, 2010, DIABETOLOGIA, V53, P2480, DOI 10.1007/s00125-010-1874-x
   Palta P, 2014, PSYCHOSOM MED, V76, P12, DOI 10.1097/PSY.0000000000000009
   Park M, 2015, CLIN GERIATR MED, V31, P117, DOI 10.1016/j.cger.2014.08.022
   Ravona-Springer R, 2017, DIABETES CARE, V40, P1187, DOI 10.2337/dc16-2754
   Tabák AG, 2014, LANCET DIABETES ENDO, V2, P236, DOI 10.1016/S2213-8587(13)70139-6
   Tang WK, 2004, INT J PSYCHIAT MED, V34, P155, DOI 10.2190/9YJ9-NNXA-RJCY-2DYP
   Ting RZW, 2013, J AFFECT DISORDERS, V149, P129, DOI 10.1016/j.jad.2013.01.012
   Trief P., 2007, Diabetes Spectrum, V20, P71, DOI [10.2337/diaspect.20.2.71, DOI 10.2337/DIASPECT.20.2.71]
   Tse G, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2848759
   Tse G, 2016, FRONT PHYSIOL, V7, DOI 10.3389/fphys.2016.00313
   van Dooren FEP, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057058
   Zhang YY, 2015, J DIABETES, V7, P800, DOI 10.1111/1753-0407.12238
   Zhang YY, 2013, J AFFECT DISORDERS, V151, P660, DOI 10.1016/j.jad.2013.07.014
NR 38
TC 27
Z9 31
U1 1
U2 27
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAY 29
PY 2018
VL 9
AR 261
DI 10.3389/fendo.2018.00261
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA GH3MY
UT WOS:000433307900001
PM 29896155
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Faugere, M
   Micoulaud-Franchi, JA
   Faget-Agius, C
   Lançon, C
   Cermolacce, M
   Richieri, R
AF Faugere, M.
   Micoulaud-Franchi, J. -A.
   Faget-Agius, C.
   Lancon, C.
   Cermolacce, M.
   Richieri, R.
TI Quality of life is associated with chronic inflammation in depression: A
   cross-sectional study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Quality of life; Inflammation; C-reactive protein; Depression
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; METAANALYSIS; DISORDER; CRP;
   SCHIZOPHRENIA; SCALE; LEVEL
AB Background: Inflammation may play a crucial role in the pathophysiology of depression. However, the association between chronic inflammation and health outcomes in depression remains unclear, particularly for patient-reported outcomes.
   Methods: The aim of this study was to investigate the relationship between quality of life (QoL) (physical and mental health, assessed by the SF-36) and chronic inflammation assessed using C-reactive protein (CRP) in patients with current major depressive disorder.
   Results: One hundred eighty-one patients with depression were enrolled in this study. After adjusting for key socio-demographic, clinical and biological confounding factors, patients with high levels of CRP (> 3.0 mg/L) had worse physical health than those with normal CRP levels (OR = 0.95, 95% CI = 0.92-0.99). Significant associations were found between a higher rate of metabolic syndrome (OR = 0.10, 95% CI = 0.02-0.41) and high CRP levels.
   Limitations: The cut-off point for high cardiovascular risk was used to define the two groups: normal CRP level and high CRP level. CRP was the sole marker of inflammation in this study and was collected at only one time point. The design of this study is cross-sectional and there are no conclusions about the directionality of the association between QoL and inflammation in depression. QoL was assessed only by SF-36 scores.
   Conclusion: This study found an association between SF-36 physical health score and CRP in patients with depression, thereby showing the need to consider physical well-being in depression. This paves the way for interventions to act both on inflammation and QoL in patients with depression.
C1 [Faugere, M.; Faget-Agius, C.; Lancon, C.; Richieri, R.] La Concept Univ Hosp, Dept Psychiat, F-13005 Marseille, France.
   [Faugere, M.; Faget-Agius, C.; Lancon, C.; Richieri, R.] Aix Marseille Univ, Self Perceived Hlth Assessment Res Unit, EA 3279, F-13005 Marseille, France.
   [Micoulaud-Franchi, J. -A.] Pellegrin Univ Hosp, Dept Clin Neurophysiol, Sleep Clin, F-33076 Bordeaux, France.
   [Micoulaud-Franchi, J. -A.] Bordeaux Univ, Res Unit, USR CNRS SANPSY 3413, F-33000 Bordeaux, France.
   [Cermolacce, M.] St Marguerite Univ Hosp, SHU Adult Psychiat, F-13274 Marseille, France.
   [Richieri, R.] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England.
C3 Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille;
   Aix-Marseille Universite; Universite de Bordeaux; CHU Bordeaux; Centre
   National de la Recherche Scientifique (CNRS); CNRS - National Institute
   for Biology (INSB); Universite de Bordeaux; Aix-Marseille Universite;
   Assistance Publique-Hopitaux de Marseille; University of London; King's
   College London
RP Faugere, M (corresponding author), CHU La Concept, Pole Psychiat Ctr, Serv Pr C Lancon, 147 Bd Baille, F-13005 Marseille, France.
EM melanie.faugere@ap-hm.fr
RI Faugere, Melanie/JCP-3459-2023; richieri, raphaelle/E-4707-2015
OI MICOULAUD-FRANCHI, Jean-Arthur/0000-0002-5203-8444; Faugere,
   Melanie/0000-0001-5567-8650; RICHIERI, Raphaelle/0000-0002-3901-7016
CR BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   Chirinos DA, 2017, PSYCHONEUROENDOCRINO, V82, P17, DOI 10.1016/j.psyneuen.2017.04.011
   Cummings DM, 2003, ANN PHARMACOTHER, V37, P1593, DOI 10.1345/aph.1D029
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   de Menezes ST, 2017, J AFFECT DISORDERS, V208, P448, DOI 10.1016/j.jad.2016.10.046
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Ellul P, 2016, ACTA PSYCHIAT SCAND, V134, P469, DOI 10.1111/acps.12656
   Elovainio M, 2009, PSYCHOSOM MED, V71, P423, DOI 10.1097/PSY.0b013e31819e333a
   Faugere M, 2015, SCI REP-UK, V5, DOI 10.1038/srep10793
   Fröhlich M, 2000, DIABETES CARE, V23, P1835, DOI 10.2337/diacare.23.12.1835
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Haapakoski R, 2015, BRAIN BEHAV IMMUN, V49, P206, DOI 10.1016/j.bbi.2015.06.001
   Hamer M, 2011, JPN PSYCHOL RES, V53, P133, DOI 10.1111/j.1468-5884.2011.00460.x
   Hamer M, 2009, BRAIN BEHAV IMMUN, V23, P413, DOI 10.1016/j.bbi.2009.01.005
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Hiles SA, 2012, PSYCHOL MED, V42, P2015, DOI 10.1017/S0033291712000128
   IsHak WW, 2011, HARVARD REV PSYCHIAT, V19, P229, DOI 10.3109/10673229.2011.614099
   Monteiro R, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/289645
   MONTGOMERY SA, 1979, BRIT J PSYCHIAT, V134, P382, DOI 10.1192/bjp.134.4.382
   SAUNDERS JB, 1993, ADDICTION, V88, P791, DOI 10.1111/j.1360-0443.1993.tb02093.x
   Song BM, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2014-006429
   Tayefi M, 2017, PSYCHONEUROENDOCRINO, V81, P63, DOI 10.1016/j.psyneuen.2017.02.035
   Valkanova V, 2013, J AFFECT DISORDERS, V150, P736, DOI 10.1016/j.jad.2013.06.004
   Vetter ML, 2013, INT J OBESITY, V37, pS38, DOI 10.1038/ijo.2013.95
   Vuksan-Cusa B, 2013, NORD J PSYCHIAT, V67, P320, DOI 10.3109/08039488.2012.745601
   Ware J. E., 1994, SF-36 physical and mental summary scales: A users manual
   Wiedlocha Magdalena, 2017, PROG NEUROPSYCHO APR
   Wysokinski Adam, 2014, NORD J PSYCHIAT, P1
NR 28
TC 16
Z9 18
U1 0
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD FEB
PY 2018
VL 227
BP 494
EP 497
DI 10.1016/j.jad.2017.11.061
PG 4
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA FV1LP
UT WOS:000424323600066
PM 29156363
DA 2025-06-11
ER

PT J
AU Stanley, SH
   Laugharne, JDE
   Chapman, M
   Balaratnasingam, S
AF Stanley, Susanne H.
   Laugharne, Jonathan D. E.
   Chapman, Murray
   Balaratnasingam, Sivasankaran
TI Kimberley Indigenous mental health: An examination of metabolic syndrome
   risk factors
SO AUSTRALIAN JOURNAL OF RURAL HEALTH
LA English
DT Article
DE Indigenous Health; mental health; primary health care; remote health;
   research and education
ID CARDIOVASCULAR-DISEASE; OBESITY; AUSTRALIANS; PREVALENCE; ILLNESS;
   SCHIZOPHRENIA; POPULATIONS; DEFINITION; PROGRAM; PEOPLE
AB Objective: There is an increased risk of physical health comorbidities in people with a mental illness. This paper examines the metabolic syndrome parameters for the general population, indigenous Australians and people with a mental illness, and compares them to a sample of predominantly indigenous adults with mental health problems.
   Design: A longitudinal (24 month) audit of patient medical records was conducted between February 2011 and March 2013.
   Setting: The Kimberley Mental Health and Drug Service in Broome, Western Australia.
   Participants: Largely indigenous adults with a mental illness. Sample numbers increased from 56 at baseline (80% indigenous) to 136 at 18 months (70% indigenous).
   Main outcome measures: Waist circumference, blood pressure, fasting lipids, and fasting blood glucose.
   Results: Preliminary assessment of the data indicates a high percentage of abnormalities at baseline and at the 18 month period on all four parameters, yet not all patients were assessed on a regular basis.
   Conclusions: Abnormalities in metabolic profiles consistent with the non-Indigenous mental health population were found. There are considerable challenges to implementing regular monitoring of physical and metabolic profiles of indigenous people in rural and remote communities.
C1 [Stanley, Susanne H.; Laugharne, Jonathan D. E.; Chapman, Murray; Balaratnasingam, Sivasankaran] Univ Western Australia, Fremantle Hosp, Sch Psychiat & Clin Neurosci, T Block,L7,1 Alma St, Fremantle, WA 6160, Australia.
   [Chapman, Murray; Balaratnasingam, Sivasankaran] Kimberley Mental Hlth & Drug Serv, Broome, WA, Australia.
C3 South Metropolitan Health Service; Fiona Stanley Fremantle Hospitals
   Group; Fremantle Hospital; University of Western Australia
RP Stanley, SH (corresponding author), Univ Western Australia, Fremantle Hosp, Sch Psychiat & Clin Neurosci, T Block,L7,1 Alma St, Fremantle, WA 6160, Australia.
EM Susanne.Stanley@uwa.edu.au
RI Stanley, Susanne/H-5882-2014
OI Stanley, Susanne/0000-0002-0404-9018
FU WA Mental Health Commission
FX This project was funded by the WA Mental Health Commission.
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   [Anonymous], 2013, AUSTR HLTH SURV 1 RE
   [Anonymous], AUSTR AB TORR STRAIT
   [Anonymous], 2006, The IDF Consensus Worldwide Definition of the Metabolic Syndrome
   Australian Bureau of Statistics, 2013, ABS
   Australian Indigenous HealthInfoNet, 2013, SUMM AUSTR IND HLTH
   Bambrick H, 2005, AUSTR INDIGENOUS HLT, V5, P1
   Barnes TRE, 2008, ACTA PSYCHIAT SCAND, V118, P26, DOI 10.1111/j.1600-0447.2008.01203.x
   Bradshaw PJ, 2009, MED J AUSTRALIA, V190, P583, DOI 10.5694/j.1326-5377.2009.tb02572.x
   Cameron AJ, 2007, DIABETES RES CLIN PR, V77, P471, DOI 10.1016/j.diabres.2007.02.002
   De Hert M, 2010, EUR PSYCHIAT, V25, pS22, DOI 10.1016/S0924-9338(10)71702-8
   Dekker JM, 2005, CIRCULATION, V112, P666, DOI 10.1161/CIRCULATIONAHA.104.516948
   Eldridge D, 2011, BMC PSYCHIATRY, V11, DOI 10.1186/1471-244X-11-46
   Fisman EZ, 2014, CARDIOL J, V21, P1, DOI 10.5603/CJ.a2013.0054
   Hodge AM, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-700
   John AP, 2009, MED J AUSTRALIA, V190, P176, DOI 10.5694/j.1326-5377.2009.tb02342.x
   Lawrence D, 2001, DUTY CARE PREVENTABL
   Li M, 2012, OBESITY, V20, P1308, DOI 10.1038/oby.2011.156
   McDermott RA, 2010, MED J AUSTRALIA, V192, P562, DOI 10.5694/j.1326-5377.2010.tb03636.x
   Meyer JM, 2009, ACTA PSYCHIAT SCAND, V119, P4, DOI 10.1111/j.1600-0447.2008.01317.x
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   O'Neal DN, 2008, ATHEROSCLEROSIS, V201, P368, DOI 10.1016/j.atherosclerosis.2008.03.022
   Ojala K, 2008, J PSYCHOPHARMACOL, V22, P33, DOI 10.1177/0269881107077815
   Padmavati R, 2010, SCHIZOPHR RES, V121, P199, DOI 10.1016/j.schres.2010.05.010
   Stanley S, 2010, CLIN GUIDELINES PHYS
   Stanley SH, 2013, SOC PSYCH PSYCH EPID, V48, P487, DOI 10.1007/s00127-012-0546-1
   Stanley SH, 2011, AUST NZ J PSYCHIAT, V45, P824, DOI 10.3109/00048674.2011.614591
   Stern MP, 2004, DIABETES CARE, V27, P2676, DOI 10.2337/diacare.27.11.2676
   Taylor D, 2004, BRIT J PSYCHIAT, V185, P152, DOI 10.1192/bjp.185.2.152
   van Nieuwenhuizen A, 2013, EPIDEMIOL PSYCH SCI, V22, P255, DOI 10.1017/S2045796012000571
   Vidarsdottir S, 2010, J CLIN ENDOCR METAB, V95, P118, DOI 10.1210/jc.2008-1815
   Wang ZM, 2007, METABOLISM, V56, P629, DOI 10.1016/j.metabol.2006.12.009
   Waterreus AJ, 2009, MED J AUSTRALIA, V190, P185, DOI 10.5694/j.1326-5377.2009.tb02344.x
   Wu MK, 2008, INT J OBESITY, V32, P436, DOI 10.1038/sj.ijo.0803750
   Zimmet PZ, 2005, MED J AUSTRALIA, V183, P175, DOI 10.5694/j.1326-5377.2005.tb06987.x
NR 35
TC 2
Z9 2
U1 2
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1038-5282
EI 1440-1584
J9 AUST J RURAL HEALTH
JI Aust. J. Rural Health
PD OCT
PY 2016
VL 24
IS 5
BP 300
EP 305
DI 10.1111/ajr.12270
PG 6
WC Public, Environmental & Occupational Health; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Nursing
GA EC7AY
UT WOS:000388289400003
PM 26689845
DA 2025-06-11
ER

PT J
AU Ho, YL
   Wu, CC
   Yen, RF
   Hung, SR
   Chen, MF
   Huang, PJ
AF Ho, YL
   Wu, CC
   Yen, RF
   Hung, SR
   Chen, MF
   Huang, PJ
TI Comparison of ischemic patterns in myocardial bridge and syndrome X:
   Evaluation by dobutamine stress echocardiography and stress thallium-201
   SPECT
SO JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
LA English
DT Article
DE syndrome X; myocardial bridge; dobutamine stress echocardiography;
   stress thallium-201 SPECT
ID EMISSION COMPUTED-TOMOGRAPHY; CORONARY-ARTERY DISEASE; LEFT-VENTRICULAR
   HYPERTROPHY; CHEST PAIN; INFARCTION; ATHEROSCLEROSIS; DYSFUNCTION;
   MILKING; SCANS
AB Background and purpose: Ischemic patterns in patients with syndrome X are thought to differ from those in patients with myocardial bridge, because the mechanisms of coronary flow reduction in these two diseases are different. The aim of this study was to compare the ischemic patterns in patients with syndrome X and those with myocardial bridge through the use of dobutamine stress echocardiography (DSE) and stress thallium-201 single-photon emission computed tomography (SPECT).
   Methods: Twenty-six patients with typical angina and stress-induced ST-segment depression were enrolled. All patients underwent coronary angiography, DSE, stress thallium-201 SPECT within 7 days after enrollment.
   Results: Of the 26 patients enrolled, 10 had myocardial bridge of the left anterior descending artery and 16 had syndrome X. Among patients with myocardial bridge, myocardial dyssynergy was found by DSE in five patients and reversible or fixed thallium-201 perfusion defects were found in four. Seven patients with myocardial bridge had reverse redistribution patterns on thallium-201 scintigraphy. In the 16 patients with syndrome X, myocardial dyssynergy was found by DSE in only one patient (p = 0.018 vs myocardial bridge group) and reversible or fixed thallium-201 perfusion defects were found in nine (p > 0.05 vs myocardial bridge group). Four patients with syndrome X had reverse redistribution patterns on thallium-201 scintigraphy. The resting left ventricular end-diastolic pressure was higher in patients with myocardial bridge than in those with syndrorne X (17 +/- 4 vs 12 +/- 5 mm Hg, p = 0.02).
   Conclusions: The most common ischemic patterns in patients with syndrome X were chest pain and stress-induced ST-segment depression, followed by myocardial perfusion defects. Dobutamine-induced dyssynergy was rare. Left ventricular end diastolic pressure elevation and dobutamine-induced wall motion abnormalities were more common in patients with myocardial bridge than in those with syndrome X.
C1 Natl Taiwan Univ Hosp, Dept Internal Med Cardiol, Taipei, Taiwan.
   Natl Taiwan Univ Hosp, Dept Nucl Med, Taipei, Taiwan.
   Natl Taiwan Univ Hosp, Dept Nucl Med, Taipei, Taiwan.
C3 National Taiwan University; National Taiwan University Hospital;
   National Taiwan University; National Taiwan University Hospital;
   National Taiwan University; National Taiwan University Hospital
RP Huang, PJ (corresponding author), Natl Taiwan Univ Hosp, Dept Internal Med Cardiol, 7 Chung-Shan S Rd, Taipei, Taiwan.
RI Wu, Chun-Ying/AAX-5077-2021
OI HO, YI-LWUN/0000-0002-8936-9570; YEN, RUOH-FANG/0000-0003-1648-6482
CR ARNESE M, 1994, AM J CARDIOL, V73, P896, DOI 10.1016/0002-9149(94)90819-2
   BAIM DS, 2000, CARDIAC CATHETERIZAT, P211
   BERGER BC, 1983, AM J CARDIOL, V52, P365, DOI 10.1016/0002-9149(83)90140-6
   BORRELLO JA, 1981, J NUCL MED, V22, P471
   CHEITLIN MD, 1975, JAMA-J AM MED ASSOC, V231, P951, DOI 10.1001/jama.231.9.951
   Cottin Y, 1995, EUR HEART J, V16, P2002, DOI 10.1093/oxfordjournals.eurheartj.a060860
   DEVEREUX RB, 1977, CIRCULATION, V55, P613, DOI 10.1161/01.CIR.55.4.613
   Diamond G A, 1983, J Am Coll Cardiol, V1, P574
   Fragasso G, 1999, G Ital Cardiol, V29, P383
   Fragasso G, 1996, EUR HEART J, V17, P1482
   GE JB, 1995, BRIT HEART J, V73, P462
   GE JB, 1994, CIRCULATION, V89, P1725, DOI 10.1161/01.CIR.89.4.1725
   HEYNDRICKX CR, 1978, AM J PHYSIOL, V234, pH653
   HO FM, 1995, EUR HEART J, V16, P570, DOI 10.1093/oxfordjournals.eurheartj.a060952
   Ho YL, 1999, AM J CARDIOL, V84, P125, DOI 10.1016/S0002-9149(99)00220-9
   Ho YL, 1998, AM HEART J, V135, P655, DOI 10.1016/S0002-8703(98)70282-0
   Ho YL, 1998, CARDIOLOGY, V89, P52, DOI 10.1159/000006743
   Ho YL, 1997, CARDIOLOGY, V88, P197, DOI 10.1159/000177329
   Huang PJ, 1998, J NUCL CARDIOL, V5, P34, DOI 10.1016/S1071-3581(98)80008-1
   Huang PJ, 1997, CARDIOLOGY, V88, P556, DOI 10.1159/000177419
   Inobe Y, 1996, J AM COLL CARDIOL, V28, P890, DOI 10.1016/S0735-1097(96)00271-9
   ISKANDRIAN AS, 1987, AM HEART J, V114, P852, DOI 10.1016/0002-8703(87)90796-4
   JUILLIERE Y, 1995, AM HEART J, V129, P663, DOI 10.1016/0002-8703(95)90312-7
   Lanzarini L, 1994, Int J Card Imaging, V10, P145, DOI 10.1007/BF01137710
   LEVY D, 1987, AM J CARDIOL, V59, P956, DOI 10.1016/0002-9149(87)91133-7
   LICHTLEN PR, 1995, J AM COLL CARDIOL, V25, P1013, DOI 10.1016/0735-1097(94)00519-V
   MASERI A, 1991, J AM COLL CARDIOL, V17, P499, DOI 10.1016/S0735-1097(10)80122-6
   NIHOYANNOPOULOS P, 1991, J AM COLL CARDIOL, V18, P1463, DOI 10.1016/0735-1097(91)90676-Z
   NIHOYANNOPOULOS P, 1995, CIRCULATION S, V92, P411
   NOBLE J, 1976, AM J CARDIOL, V37, P993, DOI 10.1016/0002-9149(76)90414-8
   PICANO E, 1987, AM J CARDIOL, V60, P508, DOI 10.1016/0002-9149(87)90295-5
   PICANO E, 1997, STRESS ECHOCARDIOGRA, P246
   Razavi M, 1975, Cardiovasc Clin, V7, P25
   ROULEAU JR, 1983, CARDIOVASC RES, V17, P96, DOI 10.1093/cvr/17.2.96
   SAHN DJ, 1978, CIRCULATION, V58, P1072, DOI 10.1161/01.CIR.58.6.1072
   Schiller N B, 1989, J Am Soc Echocardiogr, V2, P358
   TWEDDEL AC, 1992, BRIT HEART J, V68, P48
NR 37
TC 3
Z9 4
U1 0
U2 0
PU EXCERPTA MEDICA ASIA LTD
PI CHAI WAN
PA 19/F, EIGHT COMMERCIAL TOWER, 8 SUN YIP ST, CHAI WAN, HONG KONG
SN 0929-6646
J9 J FORMOS MED ASSOC
JI J. Formos. Med. Assoc.
PD FEB
PY 2001
VL 100
IS 2
BP 83
EP 88
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 423YX
UT WOS:000168206300002
PM 11393106
DA 2025-06-11
ER

PT J
AU Carpiniello, B
   Pinna, F
   Velluzzi, F
   Loviselli, A
AF Carpiniello, B.
   Pinna, F.
   Velluzzi, F.
   Loviselli, A.
TI Mental disorders in patients with metabolic syndrome. The key role of
   central obesity
SO EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
LA English
DT Article
DE Metabolic syndrome; central obesity; current prevalence; mental
   disorders; anxiety disorders; mood disorders; binge eating disorders
ID QUALITY-OF-LIFE; DEPRESSIVE SYMPTOMS; PSYCHIATRIC COMORBIDITY;
   NATIONAL-HEALTH; PREVALENCE; RISK; ANXIETY; WOMEN; POPULATION;
   OVERWEIGHT
AB BACKGROUND: The Authors sought to evaluate current prevalence of mental disorders in patients affected by metabolic syndrome compared with patients affected by central obesity alone. METHODS: 186 (63.5%) patients affected by central obesity and 107 (36.5%) affected by metabolic syndrome according to ICF criteria were interviewed by means of SCID I. RESULTS: Axis I current prevalence was respectively 45.7% and 44.9% among patients with central obesity and patients with metabolic syndrome, differences which were not significant. No statistically significant differences were found between groups as far as each single axis I diagnostic category was concerned. Moreover, current prevalence of any axis I, anxiety and mood disorders were independent of the number of components of metabolic syndrome. CONCLUSION: metabolic syndrome is associated to an higher risk for current mental disorders, which seems to be mainly due to the strong association of central obesity to psychopathology. (Eat. Weight Disord 17: e259-e266, 2012). (c) 2012, Editrice Kurtis
C1 [Carpiniello, B.; Pinna, F.] Univ Cagliari, Dept Publ Hlth Clin & Mol Med, Sect Psychiat, I-09127 Cagliari, Italy.
   [Carpiniello, B.; Pinna, F.] Univ Cagliari, Psychiat Clin, I-09127 Cagliari, Italy.
   [Velluzzi, F.; Loviselli, A.] Univ Cagliari, Ctr Diag & Treatment Obes, Hosp Policlin, I-09127 Cagliari, Italy.
C3 University of Cagliari; University of Cagliari; University of Cagliari
RP Carpiniello, B (corresponding author), Univ Cagliari, Dept Publ Hlth Clin & Mol Med, Sect Psychiat, Via Liguria 13, I-09127 Cagliari, Italy.
EM bcarpini@iol.it
RI Pinna, Federica/LRU-3388-2024
OI Pinna, Federica/0000-0002-3108-9509
CR American Psychiatric Association, 2000, spectrum disorders using the current DSM-IV-TR diagnostic, V4th, DOI 10.1176/dsm10.1176/appi.books.9780890420249.dsm-iv-tr
   [Anonymous], 2006, IDF CONS WORLDW DEF
   BLACK DW, 1992, AM J PSYCHIAT, V149, P227
   Carpiniello B, 2001, INT J PSYCHIAT MED, V4, P369
   Carpiniello B, 2009, EPIDEMIOL PSICHIAT S, V18, P119, DOI 10.1017/S1121189X00001007
   Carpiniello B, 2009, INT J PSYCHIAT MED, V39, P63, DOI 10.2190/PM.39.1.e
   Cohen BE, 2010, PSYCHIAT RES, V175, P133, DOI 10.1016/j.psychres.2009.02.004
   de Girolamo G, 2006, SOC PSYCH PSYCH EPID, V41, P853, DOI 10.1007/s00127-006-0097-4
   DEROGATIS L R, 1973, Psychopharmacology Bulletin, V9, P13
   Everson-Rose SA, 2004, DIABETES CARE, V27, P2856, DOI 10.2337/diacare.27.12.2856
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   First MB, 1996, Structured Clinical Interview for the DSM-IV-TR Axis I Disorders, DOI DOI 10.1037/T07827-000
   First MB, 1996, STRUCTURED CLIN ITER
   Gariepy G, 2010, INT J OBESITY, V34, P407, DOI 10.1038/ijo.2009.252
   Goldbacher EM, 2007, ANN BEHAV MED, V34, P240, DOI 10.1007/BF02874549
   Guy W., 1976, ECDEU Assessment Manual for Psychopharmacology, Revised. US Department of Health, Education, and Welfare Publication (ADM), P76
   Hidrum B, 2007, BMC PUBLIC HEALTH, V7, P220
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jonas BS, 1997, ARCH FAM MED, V6, P43, DOI 10.1001/archfami.6.1.43
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178, DOI 10.4088/JCP.v69n0202
   Lett HS, 2004, PSYCHOSOM MED, V66, P305, DOI 10.1097/01.psy.0000126207.43307.c0
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   McEvoy JP, 2005, SCHIZOPHR RES, V80, P19, DOI 10.1016/j.schres.2005.07.014
   Mittal VA, 2011, PSYCHIAT RES, V189, P158, DOI 10.1016/j.psychres.2011.06.006
   Newcomer JW, 2007, AM J MANAG CARE, V13, pS170
   Ohaeri JU, 2011, METAB SYNDR RELAT D, V9, P91, DOI 10.1089/met.2010.0053
   Petry NM, 2008, PSYCHOSOM MED, V70, P288, DOI 10.1097/PSY.0b013e3181651651
   Pinna F, 2011, EAT WEIGHT DISORD-ST, V16, pE164, DOI 10.3275/7509
   Preti A, 2009, J PSYCHIATR RES, V43, P1125, DOI 10.1016/j.jpsychires.2009.04.003
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Rosolova H, 2009, Vnitr Lek, V55, P650
   Skevington SM, 2004, QUAL LIFE RES, V13, P299, DOI 10.1023/B:QURE.0000018486.91360.00
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Takeuchi T, 2009, DIABETES METAB, V35, P32, DOI 10.1016/j.diabet.2008.06.006
   Toker S, 2008, DEPRESS ANXIETY, V25, P661, DOI 10.1002/da.20379
   Turhan H, 2005, CORONARY ARTERY DIS, V16, P37, DOI 10.1097/00019501-200502000-00007
   Tuthill A, 2006, QJM-INT J MED, V99, P317, DOI 10.1093/qjmed/hcl041
   Vanhala M, 2009, ACTA PSYCHIAT SCAND, V119, P137, DOI 10.1111/j.1600-0447.2008.01283.x
NR 39
TC 14
Z9 14
U1 0
U2 13
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1124-4909
EI 1590-1262
J9 EAT WEIGHT DISORD-ST
JI Eat. Weight Disord.-Stud. Anorex.
PD DEC
PY 2012
VL 17
IS 4
BP E259
EP E266
DI 10.3275/8809
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA 098GG
UT WOS:000315534900005
PM 23299201
DA 2025-06-11
ER

PT J
AU Henderson, KN
   Killen, LG
   O'Neal, EK
   Waldman, HS
AF Henderson, Kaemmer N.
   Killen, Lauren G.
   O'Neal, Eric K.
   Waldman, Hunter S.
TI The Cardiometabolic Health Benefits of Sauna Exposure in Individuals
   with High-Stress Occupations. A Mechanistic Review
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Review
DE firefighters; police; military; oxidative stress; inflammation;
   performance
ID ACTIVATED PROTEIN-KINASE; C-REACTIVE PROTEIN; ISCHEMIC-HEART-DISEASE;
   CARDIOVASCULAR-DISEASE; PSYCHOLOGICAL STRESS; IMPROVES MARKERS; THERMAL
   THERAPY; LIPID PROFILE; FIREFIGHTERS; AMPK
AB Components of the metabolic syndrome (i.e., hypertension, insulin resistance, obesity, atherosclerosis) are a leading cause of death in the United States and result in low-grade chronic inflammation, excessive oxidative stress, and the eventual development of cardiometabolic diseases (CMD). High-stress occupations (HSO: firefighters, police, military personnel, first responders, etc.) increase the risk of developing CMD because they expose individuals to chronic and multiple stressors (i.e., sleep deprivation, poor nutrition habits, lack of physical activity, psychological stress). Interestingly, heat exposure and, more specifically, sauna bathing have been shown to improve multiple markers of CMD, potentially acting as hormetic stressors, at the cellular level and in the whole organism. Therefore, sauna bathing might be a practical and alternative intervention for disease prevention for individuals with HSO. The purpose of this review is to detail the mechanisms and pathways involved in the response to both acute and chronic sauna bathing and collectively present sauna bathing as a potential treatment, in addition to current standard of care, for mitigating CMD to both clinicians and individuals serving in HSO.
C1 [Henderson, Kaemmer N.; Killen, Lauren G.; O'Neal, Eric K.; Waldman, Hunter S.] Univ North Alabama, Dept Kinesiol, Human Performance Lab, Florence, AL 35632 USA.
RP Waldman, HS (corresponding author), Univ North Alabama, Dept Kinesiol, Human Performance Lab, Florence, AL 35632 USA.
EM khenderson2@una.edu; lkillen1@una.edu; eoneal1@una.edu;
   Hswaldman@una.edu
CR Alberga AS, 2013, APPL PHYSIOL NUTR ME, V38, P249, DOI 10.1139/apnm-2012-0227
   [Anonymous], 2014, Heart disease facts
   Baxter CS, 2014, J OCCUP ENVIRON HYG, V11, pD85, DOI 10.1080/15459624.2014.890286
   Bhatti JS, 2017, BBA-MOL BASIS DIS, V1863, P1066, DOI 10.1016/j.bbadis.2016.11.010
   Biro S, 2003, EXP BIOL MED, V228, P1245, DOI 10.1177/153537020322801023
   Calabrese EJ, 2000, HUM EXP TOXICOL, V19, P2, DOI 10.1191/096032700678815585
   Calvert GM, 1999, J OCCUP ENVIRON MED, V41, P960, DOI 10.1097/00043764-199911000-00007
   Chaudhry H, 2013, IN VIVO, V27, P669
   Cheng JL, 2019, J APPL PHYSIOL, V126, P771, DOI 10.1152/japplphysiol.00682.2018
   Collier RJ, 2017, J DAIRY SCI, V100, P10367, DOI 10.3168/jds.2017-13676
   Costello JT, 2018, CYTOKINE, V110, P277, DOI 10.1016/j.cyto.2018.01.018
   Daval M, 2006, J PHYSIOL-LONDON, V574, P55, DOI 10.1113/jphysiol.2006.111484
   de Ferranti S, 2002, CLIN CHIM ACTA, V317, P1, DOI 10.1016/S0009-8981(01)00797-5
   Degan D, 2018, CURR PHARM DESIGN, V24, P1485, DOI 10.2174/1381612824666180327170632
   DUBROW R, 1988, J OCCUP ENVIRON MED, V30, P650, DOI 10.1097/00043764-198808000-00011
   Farioli A, 2015, J AM HEART ASSOC, V4, DOI 10.1161/JAHA.115.001818
   Garolla A, 2013, HUM REPROD, V28, P877, DOI 10.1093/humrep/det020
   Garrett AT, 2012, EUR J APPL PHYSIOL, V112, P1827, DOI 10.1007/s00421-011-2153-3
   Gibson AA, 2017, BEHAV SCI, V7, DOI 10.3390/bs7030044
   Gimbrone MA, 2016, CIRC RES, V118, P620, DOI 10.1161/CIRCRESAHA.115.306301
   Green KT, 2014, ADDICT BEHAV, V39, P406, DOI 10.1016/j.addbeh.2013.08.024
   Greer EL, 2009, ANN NY ACAD SCI, V1170, P688, DOI 10.1111/j.1749-6632.2009.04019.x
   Gryka D, 2014, INT J OCCUP MED ENV, V27, P608, DOI 10.2478/s13382-014-0281-9
   GUIDOTTI TL, 1992, ANNU REV PUBL HEALTH, V13, P151, DOI 10.1146/annurev.pu.13.050192.001055
   Habegger KM, 2012, ENDOCRINOLOGY, V153, P2130, DOI 10.1210/en.2011-2099
   Haddock CK, 2012, OCCUP MED-OXFORD, V62, P661, DOI 10.1093/occmed/kqs162
   Hafen PS, 2018, J APPL PHYSIOL, V125, P1447, DOI 10.1152/japplphysiol.00383.2018
   Hannuksela ML, 2001, AM J MED, V110, P118, DOI 10.1016/S0002-9343(00)00671-9
   Hartley Tara A, 2011, Int J Emerg Ment Health, V13, P211
   Hasenour CM, 2013, MOL CELL ENDOCRINOL, V366, P152, DOI 10.1016/j.mce.2012.06.018
   Herzig S, 2018, NAT REV MOL CELL BIO, V19, P121, DOI 10.1038/nrm.2017.95
   Hofmann C, 2019, CIRCULATION, V139, P2085, DOI 10.1161/CIRCULATIONAHA.118.037417
   Huang CJ, 2013, FRONT PHYSIOL, V4, DOI 10.3389/fphys.2013.00314
   Huang CJ, 2010, EXP BIOL MED, V235, P1498, DOI 10.1258/ebm.2010.010176
   Huhtaniemi IT., 2020, Curr Opin Endocr Metab Res, V11, P15, DOI [10.1016/j.coemr.2019.12.004, DOI 10.1016/J.COEMR.2019.12.004]
   Hunter AL, 2017, CIRCULATION, V135, P1284, DOI 10.1161/CIRCULATIONAHA.116.025711
   Iguchi M, 2012, J ATHL TRAINING, V47, P184
   Irving Shane, 2019, Int J Exerc Sci, V12, P173
   Janssen CW, 2016, JAMA PSYCHIAT, V73, P789, DOI 10.1001/jamapsychiatry.2016.1031
   Javadov S, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9051177
   Jin XL, 2016, J DAIRY SCI, V99, P9094, DOI 10.3168/jds.2016-11031
   Joseph PN, 2009, J OCCUP ENVIRON MED, V51, P700, DOI 10.1097/JOM.0b013e3181a02252
   Kales Stefanos N, 2003, Environ Health, V2, P14, DOI 10.1186/1476-069X-2-14
   Kawamura T, 2018, ANTIOXIDANTS-BASEL, V7, DOI 10.3390/antiox7090119
   Ketelhut S, 2019, COMPLEMENT THER MED, V44, P218, DOI 10.1016/j.ctim.2019.05.002
   Kihara T, 2002, J AM COLL CARDIOL, V39, P754, DOI 10.1016/S0735-1097(01)01824-1
   Kim HG, 2018, PSYCHIAT INVEST, V15, P235, DOI 10.30773/pi.2017.08.17
   Klotz LO, 2017, REDOX BIOL, V13, P646, DOI 10.1016/j.redox.2017.07.015
   Kukkonen-Harjula K, 2006, INT J CIRCUMPOL HEAL, V65, P195, DOI 10.3402/ijch.v65i3.18102
   KUKKONENHARJULA K, 1989, EUR J APPL PHYSIOL, V58, P543, DOI 10.1007/BF02330710
   Kunutsor SK, 2019, EUR J EPIDEMIOL, V34, P983, DOI 10.1007/s10654-019-00544-z
   Kunutsor Setor K, 2018, Neurology, V90, pe1937, DOI 10.1212/WNL.0000000000005606
   Kunutsor SK, 2017, EUR J EPIDEMIOL, V32, P1107, DOI 10.1007/s10654-017-0311-6
   Laukkanen JA, 2018, EUR J EPIDEMIOL, V33, P351, DOI 10.1007/s10654-017-0335-y
   Laukkanen T, 2018, BMC MED, V16, DOI 10.1186/s12916-018-1198-0
   Laukkanen T, 2018, J HUM HYPERTENS, V32, P129, DOI 10.1038/s41371-017-0008-z
   Laukkanen T, 2015, JAMA INTERN MED, V175, P542, DOI 10.1001/jamainternmed.2014.8187
   LEPPALUOTO J, 1988, ANN CLIN RES, V20, P240
   Liu CT, 2012, J APPL PHYSIOL, V112, P354, DOI 10.1152/japplphysiol.00989.2011
   Marzabadi E., 2011, Journal of Military Medicine, V13, P1
   Masuda A, 2005, PSYCHOSOM MED, V67, P643, DOI 10.1097/01.psy.0000171812.67767.8f
   McAllister MJ, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17145042
   McAllister MJ, 2020, NUTR RES, V75, P32, DOI 10.1016/j.nutres.2019.12.001
   McMurray JJV, 2013, CIRC-HEART FAIL, V6, P451, DOI 10.1161/CIRCHEARTFAILURE.112.000143
   MILUNSKY A, 1992, JAMA-J AM MED ASSOC, V268, P882, DOI 10.1001/jama.268.7.882
   Mínguez-Alarcón L, 2018, HUM REPROD, V33, P1749, DOI 10.1093/humrep/dey259
   Mo CF, 2014, ANTIOXID REDOX SIGN, V20, P574, DOI 10.1089/ars.2012.5116
   Nguyen T, 2009, J BIOL CHEM, V284, P13291, DOI 10.1074/jbc.R900010200
   Obst PL, 2001, DRUG-EDUC PREV POLIC, V8, P347
   Park Eunju, 2016, J Phys Ther Sci, V28, P3173
   Pilch W, 2014, BIOL SPORT, V31, P145, DOI 10.5604/20831862.1099045
   Pilch W, 2010, INT J OCCUP MED ENV, V23, P167, DOI 10.2478/v10001-010-0020-9
   Poston WSC, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-805
   Reuter S, 2010, FREE RADICAL BIO MED, V49, P1603, DOI 10.1016/j.freeradbiomed.2010.09.006
   Ridker PM, 2000, CIRCULATION, V101, P1767, DOI 10.1161/01.CIR.101.15.1767
   Rozanski A, 1999, CIRCULATION, V99, P2192, DOI 10.1161/01.CIR.99.16.2192
   SELYE H, 1946, J CLIN ENDOCR METAB, V6, P117, DOI 10.1210/jcem-6-2-117
   Singh R, 2010, CURR PHARM DESIGN, V16, P796, DOI 10.2174/138161210790883499
   Singh U, 2006, ARTERIOSCL THROM VAS, V26, P2469, DOI 10.1161/01.ATV.0000241572.05292.fb
   Smith BK, 2016, AM J PHYSIOL-ENDOC M, V311, pE730, DOI 10.1152/ajpendo.00225.2016
   Sobajima M, 2013, INT J CARDIOL, V167, P237, DOI 10.1016/j.ijcard.2011.12.064
   Steinberg GR, 2009, PHYSIOL REV, V89, P1025, DOI [10.1152/physrev.00011.2008, 10.15252/embj.201488104]
   Tei C, 1996, J Cardiol, V27, P29
   Tei C, 1996, INTERNAL MED, V35, P67, DOI 10.2169/internalmedicine.35.67
   Tharrett S.J., 2012, AM COLL SPORTS MED H, P170
   Thomas DM, 2014, AM J CLIN NUTR, V100, P787, DOI 10.3945/ajcn.113.079822
   Tinken TM, 2009, HYPERTENSION, V54, P278, DOI 10.1161/HYPERTENSIONAHA.109.134361
   United States Army, 2015, HLTH FORC CREAT HLTH
   Waldman HS, 2020, J STRENGTH COND RES, V34, P2785, DOI 10.1519/JSC.0000000000003749
   Waldman HS, 2019, J STRENGTH COND RES, V33, P3284, DOI 10.1519/JSC.0000000000003354
   Walker A, 2015, ERGONOMICS, V58, P2032, DOI 10.1080/00140139.2015.1051596
   Webb HE, 2008, EUR J APPL PHYSIOL, V104, P973, DOI 10.1007/s00421-008-0852-1
   Westermann B, 2010, NAT REV MOL CELL BIO, V11, P872, DOI 10.1038/nrm3013
   Wu HP, 2009, INFLAMM RES, V58, P385, DOI 10.1007/s00011-009-0003-0
   Yamada PM, 2007, J APPL PHYSIOL, V103, P1196, DOI 10.1152/japplphysiol.00242.2007
   Yang J, 2013, AM J CARDIOL, V112, P1962, DOI 10.1016/j.amjcard.2013.08.029
   Zaccardi F, 2017, AM J HYPERTENS, V30, P1120, DOI 10.1093/ajh/hpx102
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI13505
NR 98
TC 10
Z9 11
U1 1
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD FEB
PY 2021
VL 18
IS 3
AR 1105
DI 10.3390/ijerph18031105
PG 13
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA QD0BL
UT WOS:000615193500001
PM 33513711
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Esposito, K
   Maiorino, MI
   Bellastella, G
   Panagiotakos, DB
   Giugliano, D
AF Esposito, Katherine
   Maiorino, Maria Ida
   Bellastella, Giuseppe
   Panagiotakos, Demosthenes B.
   Giugliano, Dario
TI Mediterranean diet for type 2 diabetes: cardiometabolic benefits
SO ENDOCRINE
LA English
DT Article
DE Mediterranean diet; Cardiometabolic risk; Type 2 diabetes; Glycemic
   control; Cardiovascular events
ID CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; STYLE DIET; INFLAMMATORY
   MARKERS; HEALTHY-ADULTS; RISK-FACTORS; WEIGHT-LOSS; LIFE-STYLE;
   FOLLOW-UP; METAANALYSIS
AB Dietary patterns influence various cardiometabolic risk factors, including body weight, lipoprotein concentrations, and function, blood pressure, glucose-insulin homeostasis, oxidative stress, inflammation, and endothelial health. The Mediterranean diet can be described as a dietary pattern characterized by the high consumption of plant-based foods, olive oil as the main source of fat, low-to-moderate consumption of fish, dairy products and poultry, low consumption of red and processed meat, and low-to-moderate consumption of wine with meals. The American Diabetes Association and the American Heart Association recommend Mediterranean diet for improving glycemic control and cardiovascular risk factors in type 2 diabetes. Prospective studies show that higher adherence to the Mediterranean diet is associated with a 20-23 % reduced risk of developing type 2 diabetes, while the results of randomized controlled trials show that Mediterranean diet reduces glycosylated hemoglobin levels by 0.30-0.47 %, and is also associated with a 28-30 % reduced risk for cardiovascular events. The mechanisms by which Mediterranean diet produces its cardiometabolic benefits in type 2 diabetes are, for the most, anti-inflammatory and antioxidative: increased consumption of high-quality foods may cool down the activation of the innate immune system, by reducing the production of proinflammatory cytokines while increasing that of anti-inflammatory cytokines. This may favor the generation of an anti-inflammatory milieu, which in turn may improve insulin sensitivity in the peripheral tissues and endothelial function at the vascular level and ultimately act as a barrier to the metabolic syndrome, type 2 diabetes and development of atherosclerosis.
C1 [Esposito, Katherine] Univ Naples 2, Dept Clin & Expt Med, Naples, Italy.
   [Maiorino, Maria Ida; Bellastella, Giuseppe; Giugliano, Dario] Univ Naples 2, Dept Med Surg Neurol Metab & Geriatr Sci, Naples, Italy.
   [Panagiotakos, Demosthenes B.] Harokopio Univ, Dept Nutr & Dietet, Athens, Greece.
C3 Universita della Campania Vanvitelli; Universita della Campania
   Vanvitelli; Harokopio University Athens
RP Esposito, K (corresponding author), Univ Naples 2, Dept Clin & Expt Med, Naples, Italy.
EM katherine.esposito@unina2.it
RI Panagiotakos, Demosthenes/K-8294-2019; Esposito,
   Katherine/AHE-2564-2022; Maiorino, Maria Ida/AHE-9986-2022; Maiorino,
   Maria Ida/K-3264-2016
OI Maiorino, Maria Ida/0000-0003-4659-7546; Giugliano,
   Dario/0000-0002-9377-873X
FU Associazione Salute con Stile
FX This work was supported in part by the "Associazione Salute con Stile".
CR Ajala O, 2013, AM J CLIN NUTR, V97, P505, DOI 10.3945/ajcn.112.042457
   [Anonymous], 2015, Dietary Guidelines for Americans
   Babio N, 2014, CAN MED ASSOC J, V186, pE649, DOI 10.1503/cmaj.140764
   Calder PC, 2011, BRIT J NUTR, V106, pS1, DOI 10.1017/S0007114511005460
   Carter P, 2014, J HUM NUTR DIET, V27, P280, DOI 10.1111/jhn.12138
   Cespedes EM, 2016, AM J EPIDEMIOL, V183, P622, DOI 10.1093/aje/kwv241
   Chrysohoou C, 2004, J AM COLL CARDIOL, V44, P152, DOI 10.1016/j.jacc.2004.03.039
   Esposito K, 2006, EUR HEART J, V27, P15, DOI 10.1093/eurheartj/ehi605
   Esposito K, 2012, DIABETES OBES METAB, V14, P228, DOI 10.1111/j.1463-1326.2011.01512.x
   Esposito K, 2003, JAMA-J AM MED ASSOC, V289, P1799, DOI 10.1001/jama.289.14.1799
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   Esposito K, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2015-008222
   Esposito K, 2014, ENDOCRINE, V47, P107, DOI 10.1007/s12020-014-0264-4
   Esposito K, 2014, DIABETES CARE, V37, P1824, DOI 10.2337/dc13-2899
   Esposito K, 2014, ENDOCRINE, V46, P176, DOI 10.1007/s12020-014-0165-6
   Esposito K, 2011, METAB SYNDR RELAT D, V9, P1, DOI 10.1089/met.2010.0031
   Esposito K, 2009, ANN INTERN MED, V151, P306, DOI 10.7326/0003-4819-151-5-200909010-00004
   Estruch R, 2018, NEW ENGL J MED, V378, DOI [10.1056/NEJMoa1800389, 10.1056/NEJMoa1200303, 10.1056/nejmoa1800389]
   Estruch R, 2013, NEW ENGL J MED, V368, P1279, DOI 10.1056/NEJMoa1200303
   Estruch R, 2006, ANN INTERN MED, V145, P1, DOI 10.7326/0003-4819-145-1-200607040-00004
   Evert AB, 2014, DIABETES CARE, V37, pS120, DOI 10.2337/dc14-S120
   Ezzati M, 2013, NEW ENGL J MED, V369, P954, DOI 10.1056/NEJMra1203528
   Fox CS, 2015, DIABETES CARE, V38, P1777, DOI [10.1161/CIR.0000000000000230, 10.2337/dci15-0012]
   Gazzaruso C, 2016, ENDOCRINE, V53, P347, DOI 10.1007/s12020-016-0947-0
   Georgousopoulou EN, 2014, INT J FOOD SCI NUTR, V65, P3, DOI 10.3109/09637486.2013.827634
   Giugliano D, 2008, CURR OPIN LIPIDOL, V19, P63, DOI 10.1097/MOL.0b013e3282f2fa4d
   Howard BV, 2006, JAMA-J AM MED ASSOC, V295, P655, DOI 10.1001/jama.295.6.655
   Huo R, 2015, EUR J CLIN NUTR, V69, P1200, DOI 10.1038/ejcn.2014.243
   Kastorini CM, 2011, J AM COLL CARDIOL, V57, P1299, DOI 10.1016/j.jacc.2010.09.073
   Koloverou E, 2014, METABOLISM, V63, P903, DOI 10.1016/j.metabol.2014.04.010
   Kopel E, 2014, ANN INTERN MED, V161, P157, DOI [10.7326/L14-5014, 10.7326/M13-1725, 10.7326/L14-5014-2]
   Maiorino MI, 2017, ENDOCRINE, V55, P360, DOI 10.1007/s12020-016-0993-7
   Maiorino MI, 2016, ENDOCRINE, V54, P634, DOI 10.1007/s12020-016-0881-1
   Maiorino MI, 2016, DIABETES CARE, V39, pE44, DOI 10.2337/dc15-2356
   Murray CJL, 2013, JAMA-J AM MED ASSOC, V310, P591, DOI 10.1001/jama.2013.13805
   Murray CJL, 2013, LANCET, V381, P997, DOI 10.1016/S0140-6736(13)60355-4
   Pitsavos C, 2005, AM J CLIN NUTR, V82, P694, DOI 10.1093/ajcn/82.3.694
   Ryan M, 2000, QJM-MON J ASSOC PHYS, V93, P85, DOI 10.1093/qjmed/93.2.85
   Schwingshackl L, 2014, NUTR METAB CARDIOVAS, V24, P929, DOI 10.1016/j.numecd.2014.03.003
   Schwingshackl L, 2015, PUBLIC HEALTH NUTR, V18, P1292, DOI 10.1017/S1368980014001542
   Tinker LF, 2008, ARCH INTERN MED, V168, P1500, DOI 10.1001/archinte.168.14.1500
   Wang X, 2013, DIABETES CARE, V36, P166, DOI 10.2337/dc12-0702
   Willett Walter C., 1995, American Journal of Clinical Nutrition, V61, p1402S, DOI 10.1093/ajcn/61.6.1402S
NR 43
TC 81
Z9 88
U1 2
U2 74
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD APR
PY 2017
VL 56
IS 1
BP 27
EP 32
DI 10.1007/s12020-016-1018-2
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ER6WC
UT WOS:000398948900006
PM 27395419
DA 2025-06-11
ER

PT J
AU Bharathi, A
   Kar, SS
   Satheesh, S
   Sahoo, JP
AF Bharathi, Arivarasan
   Kar, Sitanshu Sekhar
   Satheesh, Santhosh
   Sahoo, Jaya Prakash
TI Metabolic Syndrome and Its Associated Factors Among Faculty Members in a
   Tertiary Care Teaching Hospital, Puducherry: A Cross-Sectional
   Analytical Study
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE metabolic syndrome; obesity; stress; sleep; Health Personnel;
   cardiometabolic risk factors
ID PHYSICIANS HEALTH; RISK-FACTORS; PREVALENCE; DETERMINANTS; POPULATION;
   BURNOUT; STRESS; INDIA; WOMEN; URBAN
AB Background: Settings-based approach has received lot of attention under WHO renewed strategy of health promotion. It advocates regular screening/health check-ups of employees to maintain a healthy workplace. This study aimed to assess prevalence of metabolic syndrome (MetS) among faculty members and its association with selected sociodemographic, behavioral and biochemical parameters, and to determine the 10-year fatal or nonfatal cardiovascular risk using WHO-ISH risk chart.Methodology: A cross-sectional study was conducted among 252 teaching faculty members using standardized international protocols to measure behavioral risk factors (smoking, alcohol consumption, diet pattern, physical activity, sleep, and stress), physical characteristics (weight, height, waist and hip circumferences, and blood pressure), and biochemical parameters (fasting glucose and lipid profile). Risk factor profiling was done using WHO/ISH risk prediction chart.Results: Among 252 participants (males: 172 and females: 80), 58 (24.1%) were with MetS. Prevalence was higher in males (24.6%) than females (22.6%). The younger doctors (<= 40 years) had lesser prevalence of MetS compared with the elderly (>40 years) doctors (20.3% vs. 26%). Age and diet pattern were found to be independently associated with MetS. The risk of having a cardiovascular event in 10 years was <5% (low risk) for 87.5% of study participants.Conclusion: Although we included doctors who are probably the most health-conscious population, we have found that one in four have a chance of having MetS. There is a need for periodic screening program and lifestyle modification strategies to control the burden of MetS among doctors.
C1 [Bharathi, Arivarasan; Kar, Sitanshu Sekhar] JIPMER, Dept Prevent & Social Med, Pondicherry, India.
   [Satheesh, Santhosh] JIPMER, Dept Cardiol, Pondicherry, India.
   [Sahoo, Jaya Prakash] JIPMER, Dept Endocrinol, Pondicherry, India.
   [Kar, Sitanshu Sekhar] JIPMER, Dept Prevent & Social Med, Pondicherry 605006, India.
C3 Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research
RP Kar, SS (corresponding author), JIPMER, Dept Prevent & Social Med, Pondicherry 605006, India.
EM drsitanshukar@gmail.com
RI Sahoo, Jayaprakash/HHZ-2657-2022; Kar, Sitanshu Sekhar/E-6031-2011
OI Kar, Sitanshu Sekhar/0000-0001-7122-523X
CR Aanensen DM, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006968
   Adeoye AM, 2015, J CLIN HYPERTENS, V17, P880, DOI 10.1111/jch.12595
   Ahuja Maninder, 2016, J Midlife Health, V7, P126
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   [Anonymous], 2008, WHO Report on the Global Tobacco Epidemic: MPOWER Framework
   Barnett Katherine Gergen, 2014, Glob Adv Health Med, V3, P8, DOI 10.7453/gahmj.2014.061
   Bonita R., 2001, SURVEILLANCE RISK FA
   Buysse D J, 1989, Psychiatry Res, V28, P193
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Deb Soumya, 2008, Indian J Community Med, V33, P271, DOI 10.4103/0970-0218.43239
   Di Angelantonio E, 2019, LANCET GLOB HEALTH, V7, pE1332, DOI 10.1016/S2214-109X(19)30318-3
   Dooris M, 2009, PERSPECT PUBLIC HEAL, V129, P29, DOI 10.1177/1757913908098881
   Dwivedi S, 2010, INDIAN J MED SPEC, V1, P30
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Ghorpade AG, 2015, INT J HEALTH POLICY, V4, P531, DOI 10.15171/ijhpm.2015.88
   Ghosh Amit K, 2008, J Assoc Physicians India, V56, P13
   Grover S, 2018, INDIAN J PSYCHIAT, V60, P175, DOI 10.4103/psychiatry.IndianJPsychiatry_254_17
   Gupta A, 2001, J Assoc Physicians India, V49, P1148
   Hartley TA, 2012, J ENVIRON PUBLIC HEA, V2012, DOI 10.1155/2012/861219
   Hegde Shailendra Kumar B, 2016, J Family Med Prim Care, V5, P281
   Hiral Gandhi Hiral Gandhi, 2012, National Journal of Community Medicine, V3, P7
   Islam JY, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2019-035842
   Krishnaswamy K., 2011, Dietary Guidelines for Indians - A Manual
   Magalhaes P, 2014, CARDIOVASC J AFR, V25, P27, DOI 10.5830/CVJA-2013-086
   Magnavita N, 2014, RADIOL MED, V119, P142, DOI 10.1007/s11547-013-0329-0
   Manjareeka M., 2018, Asian J Pharm Clin Res, V11, P294
   Mathavan A, 2009, CAN J CARDIOL, V25, P303, DOI 10.1016/S0828-282X(09)70494-5
   Nestel P, 2007, ASIA PAC J CLIN NUTR, V16, P362
   Oberg EB, 2009, J ROY COLL PHYS EDIN, V39, P290, DOI 10.4997/JRCPE.2009.422
   Ozcelik M, 2013, J ENDOCRINOL METAB, V3, P57, DOI 10.4021/jem176w
   Pandya A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020416
   Prabhakaran D, 2007, CHRONIC ILLN, V3, P8, DOI 10.1177/1742395307079197
   Ramachandran A, 2008, J Assoc Physicians India, V56, P17
   Rampal S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046365
   Ranasinghe P, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4041-1
   Ribeiro RP, 2015, REV LAT-AM ENFERM, V23, P435
   Savitharani B B., 2016, Indian Heart J, V4, P13, DOI [DOI 10.4103/2321-449X.178119, 10.4103/2321-449X.178119]
   Sawant A, 2011, CHOLESTEROL, DOI 10.1155/2011/920983
   Schmid K, 2011, DEUT MED WOCHENSCHR, V136, P1517, DOI 10.1055/s-0031-1281547
   Shanafelt TD, 2012, ARCH INTERN MED, V172, P1377, DOI 10.1001/archinternmed.2012.3199
   Sinha S, 2013, POSTGRAD MED J, V89, P68, DOI 10.1136/postgradmedj-2012-130851
   StataCorp, 2015, Stata Statistical Software: Release 14
   Strauss M, 2016, DIABETOL METAB SYNDR, V8, DOI 10.1186/s13098-016-0174-0
   Tsai SS, 2018, DIABETOL METAB SYNDR, V10, DOI 10.1186/s13098-018-0358-x
   Venugopal V, 2019, INDIAN J COMMUN MED, V44, P21, DOI 10.4103/ijcm.IJCM_132_18
   Vidigal FD, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/s13098-015-0003-x
   WHO, 2018, GLOBAL STATUS REPORT
NR 47
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD AUG
PY 2022
VL 20
IS 6
BP 336
EP 343
DI 10.1089/met.2021.0152
EA APR 2022
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA S6IJ8
UT WOS:000789136000001
PM 35426739
DA 2025-06-11
ER

PT J
AU Fries, GR
   Zamzow, MJ
   Andrews, T
   Pink, O
   Scaini, G
   Quevedo, J
AF Fries, Gabriel R.
   Zamzow, Madeline J.
   Andrews, Taylor
   Pink, Omar
   Scaini, Giselli
   Quevedo, Joao
TI Accelerated aging in bipolar disorder: A comprehensive review of
   molecular findings and their clinical implications
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Bipolar disorder; Mania; Depression; Aging; Telomere length; DNA
   methylation; Epigenetics; mtDNA; Oxidative stress; Inflammation
ID LEUKOCYTE TELOMERE LENGTH; DNA COPY NUMBER; ENVIRONMENTAL RISK-FACTORS;
   BODY-MASS INDEX; OXIDATIVE STRESS; MOOD DISORDERS; SYSTEMIC
   INFLAMMATION; UPDATED METAANALYSIS; METABOLIC SYNDROME; PREFRONTAL
   CORTEX
AB Bipolar disorder (BD) has been associated with clinical signs of accelerated aging, which potentially underlies its association with several age-related medical conditions, such as hypertension, metabolic imbalances, dementia, and cancer. This paper aims to comprehensively review evidence of biological aging in BD and explore findings and controversies related to common biological clocks in patients, including telomere length, DNA methylation, mitochondrial DNA copy number, inflammation, and oxidative stress. Our results suggest a complex interplay between biological markers and a potential key role of environmental factors, such as childhood trauma and psychological stress, in determining premature aging in patients. Moreover, given its multifactorial nature, our summary evidences the need for further studies incorporating clinical evidence with biomarkers of accelerated aging in BD. Results of this review strongly suggest BD as an accelerated aging disease seen in both clinical and molecular aspects. Understanding the pathophysiology of aging in BD may ultimately lead to identification of pathways that can be targeted for prevention of premature aging in patients and early onset of aging-related conditions.
C1 [Fries, Gabriel R.; Zamzow, Madeline J.; Andrews, Taylor; Pink, Omar; Scaini, Giselli; Quevedo, Joao] Univ Texas Hlth Sci Ctr Houston, Louis A Faillace MD Faillace Dept Psychiat & Beha, Translat Psychiat Program, 1941 East Rd, Houston, TX 77054 USA.
   [Fries, Gabriel R.] Univ Texas Hlth Sci Ctr Houston, Sch Biomed Informat, Ctr Precis Hlth, 7000 Fannin St, Houston, TX 77030 USA.
   [Fries, Gabriel R.; Quevedo, Joao] Univ Texas MD Anderson Canc Ctr, UTHlth Grad Sch Biomed Sci, Neurosci Grad Program, Houston, TX 77030 USA.
   [Quevedo, Joao] Univ Southern Santa Catarina UNESC, Grad Program Hlth Sci, Translat Psychiat Lab, Criciuma, SC, Brazil.
   Univ Texas Hlth Sci Ctr Houston, Faillace Dept Psychiat & Behav Sci, Ctr Excellence Mood Disorders, 1941 East Rd, Houston, TX 77054 USA.
C3 University of Texas System; University of Texas Health Science Center
   Houston; University of Texas System; University of Texas Health Science
   Center Houston; University of Texas System; UTMD Anderson Cancer Center;
   Universidade do Sul de Santa Catarina; University of Texas System;
   University of Texas Health Science Center Houston
RP Fries, GR (corresponding author), 1941 East Rd,Suite 3142, Houston, TX 77054 USA.
EM Gabriel.R.Fries@uth.tmc.edu
RI Scaini, Giselli/AAX-4437-2020; Fries, Gabriel R/P-8810-2014; de Quevedo,
   Joao Luciano/E-5491-2013; Scaini, Giselli/G-1378-2014
OI Fries, Gabriel R/0000-0002-5468-2612; Andrews,
   Taylor/0000-0003-3363-1549; de Quevedo, Joao
   Luciano/0000-0003-3114-6611; Scaini, Giselli/0000-0002-9880-0887
FU UTHealth Consortium on Aging, The University of Texas Houston Retiree
   Organization (UTHRO); University of Texas Health Science Center at
   Houston (UTHealth) - Center of Excellence on Mood Disorders (USA); Pat
   Rutherford Jr.; John S. Dunn Foundation; Anne and Don Fizer Foundation
   Endowment for Depression Research - Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq); Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior (CAPES); Fundacao de Amparo a Pesquisa e
   Inovacao do Estado de Santa Catarina (FAPESC); Instituto Cerebro e
   Mente; University of Southern Santa Catarina (UNESC); UTHealth Center
   for Clinical and Translational Sciences (CCTS)
FX This study was supported in part by the UTHealth Consortium on Aging,
   The University of Texas Houston Retiree Organization (UTHRO), and the
   Louis A. Faillace, MD Department of Psychiatry and Behavioral Sciences,
   The University of Texas Health Science Center at Houston (UTHealth).
   Translational Psychiatry Program (USA) is funded by the Louis A.
   Faillace, MD Department of Psychiatry and Behavioral Sciences, McGovern
   Medical School, UTHealth. Center of Excellence on Mood Disorders (USA)
   is funded by the Pat Rutherford Jr. Chair in Psychiatry, John S. Dunn
   Foundation and Anne and Don Fizer Foundation Endowment for Depression
   Research. Translational Psychiatry Laboratory (Brazil) is funded by
   grants from Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq), Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior (CAPES), Fundacao de Amparo a Pesquisa e Inovacao do Estado de
   Santa Catarina (FAPESC), Instituto Cerebro e Mente and University of
   Southern Santa Catarina (UNESC). GRF is supported by a career
   development grant from the UTHealth Center for Clinical and
   Translational Sciences (CCTS). JQ is a 1A CNPq Research Fellow. The
   authors declare no competing interests, and funding body had no role in
   the design of the study or decision to publish.
CR Agnew-Blais J, 2016, LANCET PSYCHIAT, V3, P342, DOI 10.1016/S2215-0366(15)00544-1
   Ahmed AA, 2018, ENVIRON MOL MUTAGEN, V59, P603, DOI 10.1002/em.22206
   Alloy LB, 2005, CLIN PSYCHOL REV, V25, P1043, DOI 10.1016/j.cpr.2005.06.006
   Almeida JRC, 2009, PSYCHIAT RES-NEUROIM, V171, P54, DOI 10.1016/j.pscychresns.2008.02.001
   Amare AT, 2018, JAMA PSYCHIAT, V75, P65, DOI 10.1001/jamapsychiatry.2017.3433
   Andreazza AC, 2008, J AFFECT DISORDERS, V111, P135, DOI 10.1016/j.jad.2008.04.013
   Andreazza AC, 2009, J PSYCHIATR NEUROSCI, V34
   Andreazza AC, 2015, AM J GERIAT PSYCHIAT, V23, P314, DOI 10.1016/j.jagp.2014.05.008
   Andrejeva G, 2017, CELL METAB, V26, P49, DOI 10.1016/j.cmet.2017.06.004
   [Anonymous], 2007, BRAIN AGING MODELS M
   Arai Y, 2015, EBIOMEDICINE, V2, P1549, DOI 10.1016/j.ebiom.2015.07.029
   Arnone D, 2009, BRIT J PSYCHIAT, V195, P194, DOI 10.1192/bjp.bp.108.059717
   Astuti Y, 2017, ENVIRON RES, V158, P480, DOI 10.1016/j.envres.2017.06.038
   Ayerbe L, 2018, J AFFECT DISORDERS, V225, P665, DOI 10.1016/j.jad.2017.09.002
   Barbé-Tuana FM, 2016, REV BRAS PSIQUIATR, V38, P281, DOI 10.1590/1516-4446-2016-1910
   Barzilai N, 2016, CELL METAB, V23, P1060, DOI 10.1016/j.cmet.2016.05.011
   Bauer IE, 2019, J CLIN PSYCHIAT, V80, DOI 10.4088/JCP.18m12200
   Berk M, 2011, NEUROSCI BIOBEHAV R, V35, P804, DOI 10.1016/j.neubiorev.2010.10.001
   Betteridge DJ, 2000, METABOLISM, V49, P3, DOI 10.1016/S0026-0495(00)80077-3
   Bin Wei Y, 2015, INT J NEUROPSYCHOPH, V18, DOI 10.1093/ijnp/pyv002
   Blumberg HP, 2006, BIOL PSYCHIAT, V59, P611, DOI 10.1016/j.biopsych.2005.08.031
   Bortolato B, 2017, BIPOLAR DISORD, V19, P84, DOI 10.1111/bdi.12490
   Brown NC, 2014, PSYCHIAT RES, V218, P61, DOI 10.1016/j.psychres.2014.04.005
   Calkin CV, 2013, ANN MED, V45, P171, DOI 10.3109/07853890.2012.687835
   Cao B, 2017, MOL PSYCHIATR, V22, P1352, DOI 10.1038/mp.2016.262
   Cao B, 2016, J PSYCHIATR RES, V73, P102, DOI 10.1016/j.jpsychires.2015.12.012
   Chang CC, 2014, PSYCHIAT CLIN NEUROS, V68, P551, DOI 10.1111/pcn.12163
   Charles EF, 2016, INT J BIPOLAR DISORD, V4, DOI 10.1186/s40345-016-0054-4
   Chen HY, 2015, NUCLEUS-PHILA, V6, P183, DOI 10.1080/19491034.2015.1040212
   Chung HY, 2009, AGEING RES REV, V8, P18, DOI 10.1016/j.arr.2008.07.002
   Coello K, 2019, AUST NZ J PSYCHIAT, V53, P651, DOI 10.1177/0004867418815987
   Colpo GD, 2018, EXPERT REV NEUROTHER, V18, P139, DOI 10.1080/14737175.2018.1407242
   Colpo GD, 2015, J AFFECT DISORDERS, V186, P241, DOI 10.1016/j.jad.2015.06.034
   Cui Hang, 2012, J Signal Transduct, V2012, P646354, DOI 10.1155/2012/646354
   Dall'Olio F, 2013, AGEING RES REV, V12, P685, DOI 10.1016/j.arr.2012.02.002
   Darrow SM, 2016, PSYCHOSOM MED, V78, P776, DOI 10.1097/PSY.0000000000000356
   de Sousa RT, 2014, PROG NEURO-PSYCHOPH, V48, P32, DOI 10.1016/j.pnpbp.2013.09.002
   Dellago H, 2012, AGING-US, V4, P290, DOI 10.18632/aging.100452
   Diniz BS, 2017, AM J GERIAT PSYCHIAT, V25, P357, DOI 10.1016/j.jagp.2016.11.014
   Dröge W, 2007, AGING CELL, V6, P361, DOI 10.1111/j.1474-9726.2007.00294.x
   Dugué PA, 2018, INT J CANCER, V142, P1611, DOI 10.1002/ijc.31189
   Elvsåshagen T, 2011, J AFFECT DISORDERS, V135, P43, DOI 10.1016/j.jad.2011.08.006
   Fahy GM, 2019, AGING CELL, V18, DOI 10.1111/acel.13028
   Fasching CL, 2018, CRIT REV CL LAB SCI, V55, P443, DOI 10.1080/10408363.2018.1504274
   Finkel T, 2000, NATURE, V408, P239, DOI 10.1038/35041687
   Foote K, 2018, AGING CELL, V17, DOI 10.1111/acel.12773
   Frey BN, 2007, PROG NEURO-PSYCHOPH, V31, P283, DOI 10.1016/j.pnpbp.2006.06.011
   Fries GR, 2020, BIPOLAR DISORD, V22, P498, DOI 10.1111/bdi.12876
   Fries GR, 2019, PHARMACOL BIOCHEM BE, V177, P12, DOI 10.1016/j.pbb.2018.12.006
   Fries GR, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/s41398-017-0048-8
   Gawryluk JW, 2011, INT J NEUROPSYCHOPH, V14, P1069, DOI 10.1017/S1461145711000617
   Gielen M, 2018, AM J CLIN NUTR, V108, P453, DOI 10.1093/ajcn/nqy107
   Gildengers AG, 2007, AM J GERIAT PSYCHIAT, V15, P174, DOI 10.1097/JGP.0b013e31802dd367
   Gildengers AG, 2009, BIPOLAR DISORD, V11, P744, DOI 10.1111/j.1399-5618.2009.00739.x
   Giuffrida ML, 2018, AGING-US, V10, P1791, DOI 10.18632/aging.101518
   Glossmann HH, 2019, GERONTOLOGY, V65, P581, DOI 10.1159/000502257
   Golden TR, 2002, AGING CELL, V1, P117, DOI 10.1046/j.1474-9728.2002.00015.x
   Grammatikakis I, 2014, AGING-US, V6, P992, DOI 10.18632/aging.100710
   Grande I, 2016, LANCET, V387, P1561, DOI 10.1016/S0140-6736(15)00241-X
   Grigolon RB, 2019, PROG NEURO-PSYCHOPH, V95, DOI 10.1016/j.pnpbp.2019.109720
   Hallahan B, 2011, BIOL PSYCHIAT, V69, P326, DOI 10.1016/j.biopsych.2010.08.029
   Halper B, 2015, EXERC IMMUNOL REV, V21, P154
   Harries LW, 2012, MECH AGEING DEV, V133, P556, DOI 10.1016/j.mad.2012.07.003
   Hibar DP, 2016, MOL PSYCHIATR, V21, P1710, DOI 10.1038/mp.2015.227
   Hiluy Joao C, 2019, Prim Care Companion CNS Disord, V21, DOI 10.4088/PCC.19r02483
   Holmes C, 2013, NEUROPATH APPL NEURO, V39, P51, DOI 10.1111/j.1365-2990.2012.01307.x
   Hosnijeh FS, 2014, BLOOD, V124, P530, DOI 10.1182/blood-2013-10-532085
   Huang YC, 2018, PSYCHIAT RES, V270, P41, DOI 10.1016/j.psychres.2018.09.035
   Husain MI, 2017, J PSYCHOPHARMACOL, V31, P1137, DOI 10.1177/0269881117725711
   Huzayyin AA, 2014, INT J NEUROPSYCHOPH, V17, P561, DOI 10.1017/S1461145713001569
   Jackson JG, 2015, BIPOLAR DISORD, V17, P575, DOI 10.1111/bdi.12319
   Johnson AA, 2012, REJUV RES, V15, P483, DOI 10.1089/rej.2012.1324
   Jorgensen A, 2013, J AFFECT DISORDERS, V149, P355, DOI 10.1016/j.jad.2013.02.011
   Jung SE, 2017, BMB REP, V50, P546, DOI 10.5483/BMBRep.2017.50.11.175
   Kageyama Y, 2018, J AFFECT DISORDERS, V233, P15, DOI 10.1016/j.jad.2017.06.001
   Kakiuchi C, 2005, INT J NEUROPSYCHOPH, V8, P515, DOI 10.1017/S1461145705005213
   Kapczinski F, 2011, J PSYCHIATR RES, V45, P156, DOI 10.1016/j.jpsychires.2010.05.015
   Kawa I, 2005, BIPOLAR DISORD, V7, P119, DOI 10.1111/j.1399-5618.2004.00180.x
   Kawanishi S, 2004, ANN NY ACAD SCI, V1019, P278, DOI 10.1196/annals.1297.047
   Kessing LV, 2017, ACTA PSYCHIAT SCAND, V135, P51, DOI 10.1111/acps.12667
   Kessing LV, 2019, BIPOLAR DISORD, V21, P410, DOI 10.1111/bdi.12772
   Kim J, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0058292
   Krishnan KRR, 2005, PSYCHOSOM MED, V67, P1, DOI 10.1097/01.psy.0000151489.36347.18
   Kuszel L, 2015, J APPL GENET, V56, P169, DOI 10.1007/s13353-014-0251-8
   Lakhdar R, 2018, INT J CHRONIC OBSTR, V13, P1987, DOI 10.2147/COPD.S155952
   Levandowski ML, 2016, PROG NEURO-PSYCHOPH, V71, P83, DOI 10.1016/j.pnpbp.2016.06.009
   Li ZC, 2017, J PSYCHIATR RES, V93, P64, DOI 10.1016/j.jpsychires.2017.06.002
   Liu MY, 2016, ANN CLIN LAB SCI, V46, P260
   Lima IMM, 2015, J AFFECT DISORDERS, V172, P43, DOI 10.1016/j.jad.2014.09.043
   Mamdani F, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.134
   Marangoni C, 2018, HARVARD REV PSYCHIAT, V26, P1, DOI 10.1097/HRP.0000000000000161
   Margolis LM, 2017, J GERONTOL A-BIOL, V72, P1319, DOI 10.1093/gerona/glw243
   Martinsson L, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.37
   Mathur MB, 2016, BRAIN BEHAV IMMUN, V54, P158, DOI 10.1016/j.bbi.2016.02.002
   Mehrpooya M, 2018, J CLIN PSYCHOPHARM, V38, P460, DOI 10.1097/JCP.0000000000000938
   Mengel-From J, 2018, J ALZHEIMERS DIS, V63, P591, DOI 10.3233/JAD-171163
   Mengel-From J, 2014, HUM GENET, V133, P1149, DOI 10.1007/s00439-014-1458-9
   Merikangas KR, 2011, ARCH GEN PSYCHIAT, V68, P241, DOI 10.1001/archgenpsychiatry.2011.12
   Moreira FP, 2019, BRAZ J PSYCHIAT, V41, P38, DOI 10.1590/1516-4446-2017-2328
   Moreira FP, 2017, J PSYCHIATR RES, V92, P119, DOI 10.1016/j.jpsychires.2017.03.025
   Müezzinler A, 2014, OBES REV, V15, P192, DOI 10.1111/obr.12126
   Munkholm K, 2015, BIPOLAR DISORD, V17, P257, DOI 10.1111/bdi.12245
   Nguyen TT, 2018, J PSYCHIATR RES, V99, P50, DOI 10.1016/j.jpsychires.2018.01.013
   Noren Hooten N, 2013, AGING-US, V5, P725, DOI 10.18632/aging.100603
   Nothling J, 2020, WORLD J BIOL PSYCHIA, V21, P493, DOI 10.1080/15622975.2019.1583369
   Oh HJ, 2016, NEUROPSYCHOPHARMACOL, V41, P3080, DOI 10.1038/npp.2016.126
   Pahwa R., 2019, CHRONIC INFLAMMATION
   Palmos AB, 2018, FRONT GENET, V9, DOI 10.3389/fgene.2018.00468
   Panizzutti B, 2015, J AFFECT DISORDERS, V182, P64, DOI 10.1016/j.jad.2014.12.010
   Peters MJ, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms9570
   Pietzner M, 2017, BMC MED, V15, DOI 10.1186/s12916-017-0974-6
   Poljsak B, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/956792
   Raina A, 2017, CLIN EPIGENETICS, V9, DOI 10.1186/s13148-016-0302-6
   Reilly-Harrington NA, 2018, CURR OBES REP, V7, P294, DOI 10.1007/s13679-018-0322-y
   Révész D, 2018, J CLIN ENDOCR METAB, V103, P148, DOI 10.1210/jc.2017-01625
   Rizzo LB, 2014, NEUROSCI BIOBEHAV R, V42, P157, DOI 10.1016/j.neubiorev.2014.02.004
   Rizzo LB, 2013, BIPOLAR DISORD, V15, P832, DOI 10.1111/bdi.12121
   Roda Ângela, 2015, Trends Psychiatry Psychother., V37, P03, DOI 10.1590/2237-6089-2014-0002
   Rosenblat JD, 2016, BIPOLAR DISORD, V18, P89, DOI 10.1111/bdi.12373
   Saisho Y, 2015, ENDOCR METAB IMMUNE, V15, P196, DOI 10.2174/1871530315666150316124019
   Sayana P, 2017, J PSYCHIATR RES, V92, P160, DOI 10.1016/j.jpsychires.2017.03.018
   Scaini G, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/tp.2017.83
   Seelye A, 2019, J AFFECT DISORDERS, V246, P595, DOI 10.1016/j.jad.2018.12.076
   Simon NM, 2006, BIOL PSYCHIAT, V60, P432, DOI 10.1016/j.biopsych.2006.02.004
   Spoorthy MS, 2019, WORLD J PSYCHIATR, V9, P7, DOI 10.5498/wjp.v9.i1.7
   Squassina A, 2016, EUR NEUROPSYCHOPHARM, V26, P1241, DOI 10.1016/j.euroneuro.2016.03.020
   Starr JM, 2008, MECH AGEING DEV, V129, P745, DOI 10.1016/j.mad.2008.09.020
   Steckert AV, 2010, NEUROCHEM RES, V35, P1295, DOI 10.1007/s11064-010-0195-2
   Suire CN, 2017, EXP GERONTOL, V98, P209, DOI 10.1016/j.exger.2017.08.024
   Toma S, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00008
   Tyrka AR, 2016, BIOL PSYCHIAT, V79, P78, DOI 10.1016/j.biopsych.2014.12.025
   Unternaehrer E, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.77
   van den Ameele S, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00250
   Van den Bergh BRH, 2020, NEUROSCI BIOBEHAV R, V117, P26, DOI 10.1016/j.neubiorev.2017.07.003
   Vasconcelos-Moreno MP, 2017, INT J NEUROPSYCHOPH, V20, P445, DOI 10.1093/ijnp/pyx001
   Verhoeven JE, 2018, MOL PSYCHIATR, V23, P850, DOI 10.1038/mp.2017.48
   Versace A, 2014, MOL PSYCHIATR, V19, P200, DOI 10.1038/mp.2012.188
   Vieta E, 2018, NAT REV DIS PRIMERS, V4, DOI 10.1038/nrdp.2018.8
   Wang D, 2018, BMC PSYCHIATRY, V18, DOI 10.1186/s12888-018-1717-8
   Xia Xian, 2017, F1000Res, V6, P860, DOI 10.12688/f1000research.10692.1
   Yamagata Ana S, 2018, Mol Neuropsychiatry, V3, P192, DOI 10.1159/000486396
   Yang F, 2018, TRANSL NEUROSCI, V9, P17, DOI 10.1515/tnsci-2018-0004
   Yang XZ, 2016, MEDIAT INFLAMM, V2016, DOI 10.1155/2016/6813016
   Zhang HY, 2015, J GERONTOL A-BIOL, V70, P102, DOI 10.1093/gerona/glu145
   Zhang RY, 2017, BMC GENOMICS, V18, DOI 10.1186/s12864-017-4287-0
   Zhao YZ, 2016, MOL BIOSYST, V12, P2318, DOI 10.1039/c6mb00240d
   Zhao ZX, 2016, J AFFECT DISORDERS, V202, P120, DOI 10.1016/j.jad.2016.05.059
   Zheng Y, 2014, CELL PHYSIOL BIOCHEM, V34, P1547, DOI 10.1159/000366358
   Zole E, 2019, ARCH GERONTOL GERIAT, V83, P131, DOI 10.1016/j.archger.2019.04.007
   Zole E, 2018, MITOCHONDRIAL DNA A, V29, P431, DOI 10.1080/24701394.2017.1303490
NR 150
TC 65
Z9 68
U1 0
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD MAY
PY 2020
VL 112
BP 107
EP 116
DI 10.1016/j.neubiorev.2020.01.035
PG 10
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA LK7AX
UT WOS:000531016100008
PM 32018037
DA 2025-06-11
ER

PT J
AU Loprinzi, PD
   Cardinal, BJ
AF Loprinzi, Paul D.
   Cardinal, Bradley J.
TI Interrelationships among physical activity, depression, homocysteine,
   and metabolic syndrome with special considerations by sex
SO PREVENTIVE MEDICINE
LA English
DT Article
DE Accelerometry; Chronic disease; Epidemiology; Exercise; Population
ID ENDOTHELIUM-DEPENDENT VASODILATION; PLASMA TOTAL HOMOCYSTEINE; PROTEIN-C
   ACTIVATION; 3RD NATIONAL-HEALTH; CARDIOVASCULAR-DISEASE;
   VASCULAR-DISEASE; SELF-EFFICACY; YOUNG-ADULTS; RISK-FACTOR; EXERCISE
AB Objective. Examine the interrelationships among physical activity, depression, homocysteine and metabolic syndrome, and to examine the association between physical activity and the simultaneous presence of metabolic syndrome, depression, and high homocysteine.
   Methods. Data from the 2005-2006 National Health and Nutrition Examination Survey were used. 1146 participants were included in the analyses. Physical activity was objectively measured using accelerometry.
   Results. With respect to the association between physical activity and the simultaneous presence of these three co-morbidities, women, compared to men, had a greater strength of association. For women, compared to those participants not having metabolic syndrome or at least mild depression or high homocysteine (reference groups), the odds ratio values for participants with 1) only depression, 2) only metabolic syndrome, 3) only high homocysteine, 4) metabolic syndrome and mild depression, and 5) metabolic syndrome, mild depression and high homocysteine, respectively, were 0.74 (95% confidence interval: 0.57-0.96, 0.77 (95% confidence interval: 0.61-0.97), 1.08 (95% confidence interval: 0.66-1.76), 0.43 (95% confidence interval: 0.32-0.58), and 0.15 (95% confidence interval: 0.05-0.44), respectively.
   Conclusion. Promotion of physical activity in the adult population, especially among women, who were found to be less moderately- to vigorously-physically active than their male counterparts, may play an important role in reducing these deleterious conditions. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Loprinzi, Paul D.] Bellarmine Univ, Dept Exercise Sci, Donna & Allan Lansing Sch Nursing & Hlth Sci, Louisville, KY 40205 USA.
   [Cardinal, Bradley J.] Oregon State Univ, Coll Publ Hlth & Human Sci, Sch Biol & Populat Hlth Sci, Program Exercise & Sport Sci, Corvallis, OR 97331 USA.
C3 Bellarmine University; Oregon State University
RP Loprinzi, PD (corresponding author), Bellarmine Univ, Dept Exercise Sci, Donna & Allan Lansing Sch Nursing & Hlth Sci, Louisville, KY 40205 USA.
EM ploprinzi@bellarmine.edu; Brad.Cardinal@oregonstate.edu
RI Cardinal, Bradley/AAP-5795-2021
CR [Anonymous], NHANES SAMPL DES
   [Anonymous], 2011, National Health and Nutrition Examination Survey (NHANES) Anthropometry Procedures Manual
   [Anonymous], BREAST CANC IN PRESS
   Atienza AA, 2011, MED SCI SPORT EXER, V43, P815, DOI 10.1249/MSS.0b013e3181fdfc32
   BOUSHEY CJ, 1995, JAMA-J AM MED ASSOC, V274, P1049, DOI 10.1001/jama.274.13.1049
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   Cardinal BJ, 2004, RES Q EXERCISE SPORT, V75, P186, DOI 10.1080/02701367.2004.10609150
   Cardinal BJ, 1997, AM J HEALTH PROMOT, V12, P68, DOI 10.4278/0890-1171-12.1.68
   Chesney MA, 2006, BRIT J HEALTH PSYCH, V11, P421, DOI 10.1348/135910705X53155
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   Chrysohoou C, 2004, VASC MED, V9, P117, DOI 10.1191/1358863x04vm542oa
   Churilla JR, 2008, AM J LIFESTYLE MED, V2, P118, DOI 10.1177/1559827607311981
   Churilla James R., 2007, Metabolic Syndrome and Related Disorders, V5, P331, DOI 10.1089/met.2007.0010
   Craft LL, 2005, PSYCHOL SPORT EXERC, V6, P151, DOI 10.1016/j.psychsport.2003.11.003
   Craft Lynette L., 2004, Prim Care Companion J Clin Psychiatry, V6, P104
   Nascimento CMC, 2011, PSYCHOGERIATRICS, V11, P105, DOI 10.1111/j.1479-8301.2011.00356.x
   Dankner R, 2004, AGING CLIN EXP RES, V16, P437, DOI 10.1007/BF03327398
   de Bree A, 2001, AM J EPIDEMIOL, V154, P150, DOI 10.1093/aje/154.2.150
   Dunn AL, 2005, AM J PREV MED, V28, P1, DOI 10.1016/j.amepre.2004.09.003
   Dunn AL, 2001, MED SCI SPORT EXER, V33, pS587, DOI 10.1097/00005768-200106001-00027
   Edirisinghe SP, 2004, BRIT J BIOMED SCI, V61, P40, DOI 10.1080/09674845.2004.11732643
   Fagard RH, 2005, J HUM HYPERTENS, V19, pS20, DOI 10.1038/sj.jhh.1001956
   FRYER RH, 1993, ARTERIOSCLER THROMB, V13, P1327, DOI 10.1161/01.ATV.13.9.1327
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Guven A., 2004, European Journal of General Medicine, V1, P38
   Hajer GR, 2007, HEART, V93, P216, DOI 10.1136/hrt.2006.093971
   Haskell W L, 1984, Exerc Sport Sci Rev, V12, P205
   Hellgren M, 2005, DIABETES OBES METAB, V7, P421, DOI 10.1111/j.1463-1326.2004.00431.x
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Higashi Y, 1999, HYPERTENSION, V33, P591, DOI 10.1161/01.HYP.33.1.591
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Kingwell Bronwyn A., 1997, American Journal of Physiology, V272, pH1070
   König D, 2003, ANN NUTR METAB, V47, P114, DOI 10.1159/000070032
   Korniloff K, 2010, PREV MED, V51, P466, DOI 10.1016/j.ypmed.2010.09.007
   Koutoubi S, 2004, ETHNIC DIS, V14, P64
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Kuo HK, 2005, J INTERN MED, V258, P328, DOI 10.1111/j.1365-2796.2005.01546.x
   LENTZ SR, 1991, J CLIN INVEST, V88, P1906, DOI 10.1172/JCI115514
   Lim HS, 2002, J NUTR SCI VITAMINOL, V48, P290, DOI 10.3177/jnsv.48.290
   LussierCacan S, 1996, AM J CLIN NUTR, V64, P587, DOI 10.1093/ajcn/64.4.587
   Maeda H, 2000, HYPERTENS RES, V23, P511, DOI 10.1291/hypres.23.511
   McCaffery JM, 2003, PSYCHOSOM MED, V65, P490, DOI 10.1097/01.PSY.0000041545.52924.82
   NYGARD O, 1995, JAMA-J AM MED ASSOC, V274, P1526, DOI 10.1001/jama.274.19.1526
   Pescatello LS, 2004, MED SCI SPORT EXER, V36, P533, DOI 10.1249/01.MSS.0000115224.88514.3A
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   REN JM, 1994, J BIOL CHEM, V269, P14396
   Rinder MR, 2000, J APPL PHYSIOL, V88, P761, DOI 10.1152/jappl.2000.88.2.761
   RODGERS GM, 1990, BLOOD, V75, P895
   RUBANYI GM, 1986, AM J PHYSIOL, V250, P1145, DOI 10.1152/ajpheart.1986.250.6.H1145
   Sattar N, 2008, LANCET, V371, P1927, DOI 10.1016/S0140-6736(08)60602-9
   Saw SM, 2001, AM J CLIN NUTR, V73, P232
   Selhub J, 1999, ANN INTERN MED, V131, P331, DOI 10.7326/0003-4819-131-5-199909070-00003
   STAMLER JS, 1993, J CLIN INVEST, V91, P308, DOI 10.1172/JCI116187
   Strine TW, 2008, GEN HOSP PSYCHIAT, V30, P127, DOI 10.1016/j.genhosppsych.2007.12.008
   Tawakol A, 1997, CIRCULATION, V95, P1119
   Troiano RP, 2008, MED SCI SPORT EXER, V40, P181, DOI 10.1249/mss.0b013e31815a51b3
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
   Wald DS, 2002, BMJ-BRIT MED J, V325, P1202, DOI 10.1136/bmj.325.7374.1202
   Wang JJ, 2007, EUR HEART J, V28, P857, DOI 10.1093/eurheartj/ehl524
   Wilson Katina M, 2005, Semin Vasc Med, V5, P163, DOI 10.1055/s-2005-872401
NR 60
TC 54
Z9 59
U1 0
U2 18
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
EI 1096-0260
J9 PREV MED
JI Prev. Med.
PD JUN
PY 2012
VL 54
IS 6
BP 388
EP 392
DI 10.1016/j.ypmed.2012.03.016
PG 5
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 960HP
UT WOS:000305378900003
PM 22486943
DA 2025-06-11
ER

PT J
AU Bove, M
   Carnevali, L
   Cicero, AFG
   Grandi, E
   Gaddoni, M
   Noera, G
   Gaddi, AV
AF Bove, Marilisa
   Carnevali, Lucio
   Cicero, Arrigo F. G.
   Grandi, Elisa
   Gaddoni, Morena
   Noera, Giorgio
   Gaddi, Antonio V.
CA Massa Lombarda Project Team
TI Psychosocial factors and metabolic parameters: Is there any association
   in elderly people? The Massa Lombarda Project
SO AGING & MENTAL HEALTH
LA English
DT Article
DE depression; mental stress; metabolic syndrome; uric acid; triglycerides
ID SERUM URIC-ACID; PERCEIVED STRESS QUESTIONNAIRE; MAJOR DEPRESSIVE
   DISORDER; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; RISK-FACTORS;
   EPIDEMIOLOGY; SYMPTOMS; MEN
AB Objective: Several studies claim that psychophysical stress and depression contribute significantly to cardiovascular disease (CVD) development. The aim of our research is to discover and analyse a possible relationship between two psychosocial disorders (depression and perceived mental stress) and traditional cardiovascular risk markers. Methods: We selected 106 subjects (58 males and 48 females), mean age 79.5 +/- 3.8-years old, from the Massa Lombarda Project, an epidemiological study, including 7000 north Italian adult subjects. We carried out anamnesis, clinical and blood tests. Then, we administered the Perceived Stress Questionnaire (PSQ range score 0-1) and the Self-Rating Depression Scale (SRDS range score 50-70 Z), as validated instruments for depression and stress evaluation, which focus on the individual's subjective perception and emotional response. Statistical descriptive and inferential analyses of data collected were performed. Results: The multiple linear regression analysis showed a negative correlation between PSQ index score and uric acid, low-density lipoprotein cholesterol (LDL-c), body mass index (BMI), systolic and diastolic blood pressure values, a positive and statistically significant correlation between PSQ index score and triglycerides (p 0.05). We found an inverse relationship between Zung SRDS score and LDL-c, uric acid, glucose waist circumference values, this correlation was significant only for uric acid (p 0.01). Besides, a positive and significant correlation between Zung SRDS and triglycerides (p 0.05) was observed. Conclusion: We suppose that psycho-emotional stress and depression disorder, often diagnosed in elderly people, may influence different metabolic parameters (triglycerides, uric acid and BMI) that are involved in the complex process of metabolic syndrome.
C1 [Bove, Marilisa; Carnevali, Lucio; Cicero, Arrigo F. G.; Grandi, Elisa; Gaddi, Antonio V.] Univ Bologna, St Orsola Malpighi Hosp, Dept Aging & Kidney Dis, GC Descovich Atherosclerosis & Metab Dis Res Unit, I-40138 Bologna, Italy.
   [Gaddoni, Morena; Noera, Giorgio] Dept Cardiac Surg, I-48010 Cotignola, Ra, Italy.
C3 University of Bologna; IRCCS Azienda Ospedaliero-Universitaria di
   Bologna
RP Bove, M (corresponding author), Univ Bologna, St Orsola Malpighi Hosp, Dept Aging & Kidney Dis, GC Descovich Atherosclerosis & Metab Dis Res Unit, Via Massarenti 9, I-40138 Bologna, Italy.
EM marilisa.bove@aosp.bo.it
RI Grandi, Elisa/HLQ-5882-2023; Carnevali, Lucio/B-2335-2010; Cicero,
   Arrigo/H-8244-2019
OI Noera, Giorgio/0000-0002-2123-9964; Grandi, Elisa/0000-0003-3867-6228;
   Cicero, Arrigo Francesco Giuseppe/0000-0002-4367-3884
FU NIA NIH HHS [R01 AG019605, P30 AG028716] Funding Source: Medline
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Bagnati M, 1999, BIOCHEM J, V340, P143, DOI 10.1042/0264-6021:3400143
   Black PH, 2002, J PSYCHOSOM RES, V52, P1, DOI 10.1016/S0022-3999(01)00302-6
   BROWN SL, 1994, BRIT MED J, V308, P1328, DOI 10.1136/bmj.308.6940.1328
   DIMSDALE JE, 1982, PSYCHOSOM MED, V44, P413, DOI 10.1097/00006842-198211000-00004
   Dimsdale JE, 2008, J AM COLL CARDIOL, V51, P1237, DOI 10.1016/j.jacc.2007.12.024
   DORTLAND AKV, 2009, J CLIN PSYCHIAT
   Fliege H, 2005, PSYCHOSOM MED, V67, P78, DOI 10.1097/01.psy.0000151491.80178.78
   Frisman GH, 2009, EUR J CARDIOVASC NUR, V8, P207, DOI 10.1016/j.ejcnurse.2009.01.004
   Glantzounis GK, 2005, CURR PHARM DESIGN, V11, P4145, DOI 10.2174/138161205774913255
   Halliwell B., 1996, HDB ANTIOXIDANTS, P243
   KASL SV, 1968, J AMER MED ASSOC, V206, P1500, DOI 10.1001/jama.206.7.1500
   Keyes CLM, 2004, AGING MENT HEALTH, V8, P266, DOI 10.1080/13607860410001669804
   Kodydková J, 2009, CLIN BIOCHEM, V42, P1368, DOI 10.1016/j.clinbiochem.2009.06.006
   Kuzuya M, 2002, J GERONTOL A-BIOL, V57, pM660, DOI 10.1093/gerona/57.10.M660
   Lebowitz BD, 1997, JAMA-J AM MED ASSOC, V278, P1186, DOI 10.1001/jama.278.14.1186
   LEVENSTEIN S, 1993, J PSYCHOSOM RES, V37, P19, DOI 10.1016/0022-3999(93)90120-5
   Lippi G, 2008, CLIN CHIM ACTA, V392, P1, DOI 10.1016/j.cca.2008.02.024
   McIntyre RS, 2009, CURR DIABETES REP, V9, P51, DOI 10.1007/s11892-009-0010-0
   Menotti A, 2005, NUTR METAB CARDIOVAS, V15, P426, DOI 10.1016/j.numecd.2005.07.007
   NASCETTI S, 2004, ARCH GERONTOLOGY S1, V9, P309
   Niskanen LK, 2004, ARCH INTERN MED, V164, P1546, DOI 10.1001/archinte.164.14.1546
   Reynolds K, 2005, AM J MED SCI, V330, P273, DOI 10.1097/00000441-200512000-00004
   Rosengren A, 2004, LANCET, V364, P953, DOI 10.1016/S0140-6736(04)17019-0
   Rozanski A, 2005, J AM COLL CARDIOL, V45, P637, DOI 10.1016/j.jacc.2004.12.005
   Rozanski A, 1999, CIRCULATION, V99, P2192, DOI 10.1161/01.CIR.99.16.2192
   Sarandol A, 2007, HUM PSYCHOPHARM CLIN, V22, P67, DOI 10.1002/hup.829
   Stocker R, 2004, PHYSIOL REV, V84, P1381, DOI 10.1152/physrev.00047.2003
   Strodl E, 2003, INT J BEHAV MED, V10, P205, DOI 10.1207/S15327558IJBM1003_02
   Tsouli SG, 2006, METABOLISM, V55, P1293, DOI 10.1016/j.metabol.2006.05.013
   Van der Kooy K, 2007, INT J GERIATR PSYCH, V22, P613, DOI 10.1002/gps.1723
   WARNICK GR, 1982, CLIN CHEM, V28, P1379
   Weber-Hamann B, 2002, PSYCHOSOM MED, V64, P274, DOI 10.1097/00006842-200203000-00010
   Zauszniewski JA, 2009, AGING MENT HEALTH, V13, P64, DOI 10.1080/13607860802154481
   ZUNG WWK, 1965, ARCH GEN PSYCHIAT, V12, P63, DOI 10.1001/archpsyc.1965.01720310065008
NR 35
TC 31
Z9 34
U1 1
U2 15
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1360-7863
EI 1364-6915
J9 AGING MENT HEALTH
JI Aging Ment. Health
PY 2010
VL 14
IS 7
BP 801
EP 806
AR PII 924399607
DI 10.1080/13607861003713299
PG 6
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA 642QM
UT WOS:000281231000004
PM 20635238
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Mashele, N
   Malan, L
   van Rooyen, JM
   Harvey, BH
   Potgieter, JC
   Hamer, M
AF Mashele, Nyiko
   Malan, Leone
   van Rooyen, Johannes M.
   Harvey, Brian H.
   Potgieter, Johan C.
   Hamer, Mark
TI Depression, Cardiometabolic Function and Left Ventricular Hypertrophy in
   African Men and Women: The SABPA Study
SO CLINICAL AND EXPERIMENTAL HYPERTENSION
LA English
DT Article
DE depressive symptoms; cardiometabolic risk; left ventricular hypertrophy;
   Africans
ID METABOLIC SYNDROME; GENERAL-POPULATION; RISK; HYPERTENSION; SYMPTOMS;
   HEALTH; DISEASE; THUSA; HEART; PHQ-9
AB Depressive symptoms are associated with an increased risk for developing cardiovascular diseases, driven by its link to the metabolic syndrome (MetS). This phenomenon, however, still needs to be investigated in the African population. The aim of this study is to investigate the association between left ventricular hypertrophy (LVH) and MetS risk markers in a determined sample. The researchers stratified Black African men and women into with depressive symptoms (D) or without depressive symptoms (ND) group, based on the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria score. Fasting MetS, chronic hyperglycemia (HbA1c), ambulatory blood pressure (BP) and Cornell product-LVH (CP-LVH) in ECG measures were obtained. Depressive symptoms were reported in 45.3% of the sample. Independent of depression status, African men and women revealed a pre-diabetic state (glycated hemoglobin >5.7%). CP-LVH was associated with decreased low high-density lipoprotein cholesterol in D African women. In D African men, systolic BP (P = .001) and HbA1c (P = .08) explained 64% and 31% of the variation in LVH, respectively. In conclusion, depressive symptoms in Black African women were associated with a measure of target end organ damage, CP-LVH, and this association was driven by a metabolic factor. In Black African men, independent of depressive symptoms, LVH, was driven by cardiometabolic factors, namely SBP and HbA1c.
C1 [Mashele, Nyiko; Malan, Leone; van Rooyen, Johannes M.] North West Univ, HART, Sch Physiol Nutr & Consumer Sci, ZA-2520 Potchefstroom, South Africa.
   [Harvey, Brian H.] North West Univ, Div Pharmacol, Sch Pharm, Unit Drug Res & Dev, ZA-2520 Potchefstroom, South Africa.
   [Potgieter, Johan C.] North West Univ, Sch Psychosocial Behav Sci, ZA-2520 Potchefstroom, South Africa.
   [Hamer, Mark] UCL, Dept Epidemiol & Publ Hlth, London, England.
C3 North West University - South Africa; North West University - South
   Africa; North West University - South Africa; University of London;
   University College London
RP Malan, L (corresponding author), North West Univ, HART, Sch Physiol Nutr & Consumer Sci, Potchefstroom Campus,Private Bag X6001,Corner Ho, ZA-2520 Potchefstroom, South Africa.
EM leone.malan@nwu.ac.za
RI Malan, Leone/Q-8187-2019; Hamer, Mark/C-1602-2008; Malan,
   Leone/D-7203-2014
OI Hamer, Mark/0000-0002-8726-7992; Malan, Leone/0000-0003-3187-2410;
   Harvey, Brian/0000-0002-9864-7894
FU HART (North-West University); National Research Foundation South Africa,
   Metabolic Syndrome Institute, France [UID 65607]
FX The SABPA study was carried out by a multidisciplinary team from the
   HART, North-West University. This work was supported by the HART
   (North-West University) and National Research Foundation South Africa
   (UID 65607), Metabolic Syndrome Institute, France. The authors report no
   conflicts of interest. The authors alone are responsible for the content
   and writing of the paper.
CR Abildgaard A, 2011, PSYCHONEUROENDOCRINO, V36, P623, DOI 10.1016/j.psyneuen.2010.09.004
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   Bjorntorp P, 1997, ACTA PHYSIOL SCAND, V161, P144
   Brownhill S, 2005, AUST NZ J PSYCHIAT, V39, P921, DOI 10.1111/j.1440-1614.2005.01665.x
   Carney RM, 2005, PSYCHOSOM MED, V67, pS29, DOI 10.1097/01.psy.0000162254.61556.d5
   Dimsdale JE, 2008, J AM COLL CARDIOL, V51, P1237, DOI 10.1016/j.jacc.2007.12.024
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   Duru O Kenrik, 2009, Med Care, V47, P700
   Frasure-Smith N, 2005, PSYCHOSOM MED, V67, pS19, DOI 10.1097/01.psy.0000162253.07959.db
   Frasure-Smith N, 2009, CIRCULATION, V120, P134, DOI 10.1161/CIRCULATIONAHA.109.851675
   Golden SH, 2008, JAMA-J AM MED ASSOC, V299, P2751, DOI 10.1001/jama.299.23.2751
   Horio T, 2003, AM J HYPERTENS, V16, P938, DOI 10.1016/S0895-7061(03)01015-X
   Ishikawa J, 2009, HYPERTENSION, V53, P28, DOI 10.1161/HYPERTENSIONAHA.108.118026
   Jarvis MJ, 2001, TOB CONTROL, V10, P368, DOI 10.1136/tc.10.4.368
   Joynt KE, 2003, BIOL PSYCHIAT, V54, P248, DOI 10.1016/S0006-3223(03)00568-7
   Kalinowski L, 2004, CIRCULATION, V109, P2511, DOI 10.1161/01.CIR.0000129087.81352.7A
   Kroenke K, 2002, PSYCHIAT ANN, V32, P509, DOI 10.3928/0048-5713-20020901-06
   Lecrubier Y, 2001, J CLIN PSYCHIAT, V62, P4
   Löwe B, 2004, J AFFECT DISORDERS, V81, P61, DOI 10.1016/S0165-0327(03)00198-8
   Malan L, 2008, BIOL PSYCHOL, V79, P323, DOI 10.1016/j.biopsycho.2008.07.007
   Marfell-Jones M., 2006, ISAK manual: international standards for anthropometric assessment
   Mashele N, 2010, CARDIOVASC J AFR, V21, P206
   McCaffery JM, 2003, PSYCHOSOM MED, V65, P490, DOI 10.1097/01.PSY.0000041545.52924.82
   Monahan PO, 2009, J GEN INTERN MED, V24, P189, DOI 10.1007/s11606-008-0846-z
   Muhtz C, 2009, PSYCHONEUROENDOCRINO, V34, P1004, DOI 10.1016/j.psyneuen.2009.01.016
   Opie LH, 2005, CIRCULATION, V112, P3562, DOI 10.1161/CIRCULATIONAHA.105.539569
   Prinsloo J, 2011, EXP CLIN ENDOCR DIAB, V119, P599, DOI 10.1055/s-0031-1280801
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Räikkönen K, 2007, DIABETES CARE, V30, P872, DOI 10.2337/dc06-1857
   Rozanski A, 2005, J AM COLL CARDIOL, V45, P637, DOI 10.1016/j.jacc.2004.12.005
   Schutte AE, 2007, HORM METAB RES, V39, P651, DOI 10.1055/s-2007-985394
   Seedat YK, 2009, CARDIOVASC J AFR, V20, P39
   Tomlinson M, 2007, J AFFECT DISORDERS, V102, P191, DOI 10.1016/j.jad.2006.09.029
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
   van Rooyen JM, 2000, J HUM HYPERTENS, V14, P779, DOI 10.1038/sj.jhh.1001098
   Verdecchia P, 1998, J AM COLL CARDIOL, V31, P383, DOI 10.1016/S0735-1097(97)00493-2
   Vitaliano PP, 2002, PSYCHOSOM MED, V64, P418, DOI 10.1097/00006842-200205000-00006
   Vogelzangs N, 2007, PSYCHONEUROENDOCRINO, V32, P151, DOI 10.1016/j.psyneuen.2006.11.009
   Weber-Hamann B, 2005, NEUROENDOCRINOLOGY, V81, P200, DOI 10.1159/000087003
   Williams JR, 2008, B WORLD HEALTH ORGAN, V86, P650, DOI 10.2471/BLT.08.050955
NR 41
TC 8
Z9 9
U1 0
U2 1
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1064-1963
EI 1525-6006
J9 CLIN EXP HYPERTENS
JI Clin. Exp. Hypertens.
PY 2013
VL 35
IS 3
BP 213
EP 219
DI 10.3109/10641963.2012.721837
PG 7
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA 117MG
UT WOS:000316956900009
PM 22954159
DA 2025-06-11
ER

PT J
AU Prabhakar, AP
   Lopez-Candales, A
AF Prabhakar, Akruti Patel
   Lopez-Candales, Angel
TI Calcific aortic valve disease and cardiometabolic triggers: an
   explanation behind progression of aortic valvular disease and failure of
   medical therapy interventions
SO POSTGRADUATE MEDICINE
LA English
DT Review
DE Aortic stenosis; metabolic syndrome; obesity; hypertension; morbidity;
   mortality
ID METABOLIC SYNDROME; ENDOTHELIAL-CELLS; IN-VIVO; OXIDIZED PHOSPHOLIPIDS;
   MECHANICAL-PROPERTIES; PSYCHOLOGICAL STRESS; EARLY LESION; STENOSIS;
   HEART; ASSOCIATION
AB Calcific aortic valve disease (CAVD), a nonrheumatic stenosis of the trileaflet aortic valve, is a complex, multifaceted cardiovascular condition involving a widespread inflammatory process and an analogous atheromatous process affecting the arteries. It is currently the most encountered valvular abnormality in cardiology. Although distinctive abnormal mechanical forces are at the core propelling a responsive mechanosensitive feedback cascade, implicated in both initiation and perpetuation of CAVD; we propose a conundrum of metabolic abnormalities including hypertension, elevated fasting blood sugar, decreased high-density lipoprotein, hypertriglyceridemia, and abdominal obesity as perpetuators of this process. Furthermore, we suggest CAVD as a cardio metabolic disorder. New perspectives as well as which pathways we believe are critically involved and ideas for early intervention are discussed.
C1 [Prabhakar, Akruti Patel] Univ Louisville, Dept Cardiovasc Med, Louisville, KY USA.
   [Lopez-Candales, Angel] Dayton VA Med Ctr, Wright State Boonshoft Sch Med, Cardiol Sect, Dayton, OH 45428 USA.
C3 University of Louisville; University System of Ohio; Wright State
   University Dayton
RP Lopez-Candales, A (corresponding author), Dayton VA Med Ctr, Wright State Boonshoft Sch Med, Cardiol, 4100 Third St, Dayton, OH 45428 USA.
EM angel.lopez-candales@va.gov
OI Prabhakar, Akruti/0009-0004-2172-4259
CR Bahraseman HG, 2016, ACTA BIOENG BIOMECH, V18, P11, DOI 10.5277/ABB-00429-2015-03
   Beydoun HA, 2016, AM J CARDIOL, V118, P860, DOI 10.1016/j.amjcard.2016.06.039
   Bing R, 2019, AM HEART J, V212, P91, DOI 10.1016/j.ahj.2019.02.018
   Bjorklund G, 2020, CURR MED CHEM, V27, P1647, DOI 10.2174/0929867325666180716104159
   BREWER RJ, 1977, J THORAC CARDIOV SUR, V74, P645
   Briand M, 2006, CIRCULATION, V114, pI512, DOI 10.1161/CIRCULATIONAHA.105.000422
   Briand M, 2006, J AM COLL CARDIOL, V47, P2229, DOI 10.1016/j.jacc.2005.12.073
   BROSIUS FC, 1981, AM J MED, V70, P519, DOI 10.1016/0002-9343(81)90574-X
   Butcher JT, 2007, PHILOS T R SOC B, V362, P1445, DOI 10.1098/rstb.2007.2127
   Butcher JT, 2006, TISSUE ENG, V12, P905, DOI 10.1089/ten.2006.12.905
   Butcher JT, 2004, ARTERIOSCL THROM VAS, V24, P1429, DOI 10.1161/01.ATV.0000130462.50769.5a
   Capoulade R, 2015, J AM COLL CARDIOL, V66, P1236, DOI 10.1016/j.jacc.2015.07.020
   Capoulade R, 2014, CAN J CARDIOL, V30, P1088, DOI 10.1016/j.cjca.2014.03.025
   Capoulade R, 2012, J AM COLL CARDIOL, V60, P216, DOI 10.1016/j.jacc.2012.03.052
   Carabello BA, 2009, LANCET, V373, P956, DOI 10.1016/S0140-6736(09)60211-7
   Chan KL, 2010, CIRCULATION, V121, P306, DOI 10.1161/CIRCULATIONAHA.109.900027
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Dayawansa NH, 2022, FRONT CARDIOVASC MED, V9, DOI 10.3389/fcvm.2022.783543
   Dimsdale JE, 2008, J AM COLL CARDIOL, V51, P1237, DOI 10.1016/j.jacc.2007.12.024
   Draney MT, 2004, MAGNET RESON MED, V52, P286, DOI 10.1002/mrm.20137
   Driscoll K, 2021, CIRC RES, V128, P1344, DOI 10.1161/CIRCRESAHA.121.318011
   El-Hamamsy I, 2009, J AM COLL CARDIOL, V53, P1448, DOI 10.1016/j.jacc.2008.11.056
   Engin A, 2017, ADV EXP MED BIOL, V960, P1, DOI 10.1007/978-3-319-48382-5_1
   Everett RJ, 2018, HEART, V104, P2067, DOI 10.1136/heartjnl-2017-312304
   Faure E, 2021, INT J CARDIOL, V323, P220, DOI 10.1016/j.ijcard.2020.08.074
   Fedele M, 2017, BIOMECH MODEL MECHAN, V16, P1779, DOI 10.1007/s10237-017-0919-1
   Freeman RV, 2005, CIRCULATION, V111, P3316, DOI 10.1161/CIRCULATIONAHA.104.486738
   Gollmann-Tepeköylü C, 2023, CIRCULATION, V147, P1518, DOI 10.1161/CIRCULATIONAHA.122.063481
   Goody PR, 2020, ARTERIOSCL THROM VAS, V40, P885, DOI 10.1161/ATVBAHA.119.313067
   Grande KJ, 1998, ANN BIOMED ENG, V26, P534, DOI 10.1114/1.122
   Guembe MJ, 2020, CARDIOVASC DIABETOL, V19, DOI 10.1186/s12933-020-01166-6
   Halevi R, 2015, J BIOMECH, V48, P489, DOI 10.1016/j.jbiomech.2014.12.004
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Helske S, 2007, CURR OPIN LIPIDOL, V18, P483, DOI 10.1097/MOL.0b013e3282a66099
   Hess PL, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.117.006103
   Hill JA, 2008, NEW ENGL J MED, V358, P1370, DOI 10.1056/NEJMra072139
   Kang DH, 2020, NEW ENGL J MED, V382, P111, DOI 10.1056/NEJMoa1912846
   Katz R, 2006, CIRCULATION, V113, P2113, DOI 10.1161/CIRCULATIONAHA.105.598086
   Katz R, 2009, DIABETES, V58, P813, DOI 10.2337/db08-1515
   Kawarazaki W, 2016, AM J HYPERTENS, V29, P415, DOI 10.1093/ajh/hpw003
   Li C, 2013, CARDIOVASC PATHOL, V22, P1, DOI 10.1016/j.carpath.2012.06.005
   Liu QY, 2022, FRONT CARDIOVASC MED, V9, DOI 10.3389/fcvm.2022.877140
   Mathieu P, 2007, CAN J CARDIOL, V23, p32B, DOI 10.1016/S0828-282X(07)71008-5
   Medina-Leyte DJ, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22083850
   Mohler ER, 2004, AM J CARDIOL, V94, P1396, DOI 10.1016/j.amjcard.2004.08.013
   Mohler ER, 2001, CIRCULATION, V103, P1522, DOI 10.1161/01.cir.103.11.1522
   Monga S, 2022, JACC-CARDIOVASC IMAG, V15, P2112, DOI 10.1016/j.jcmg.2022.04.025
   Moore CJ, 2012, J ACAD NUTR DIET, V112, P518, DOI 10.1016/j.jand.2011.12.001
   Mulholland DL, 1996, CAN J CARDIOL, V12, P231
   Nadlonek NA, 2012, J THORAC CARDIOV SUR, V144, P1466, DOI 10.1016/j.jtcvs.2012.08.041
   Ngo DTM, 2009, JACC-CARDIOVASC IMAG, V2, P919, DOI 10.1016/j.jcmg.2009.03.016
   NystromRosander C, 1997, SCAND J INFECT DIS, V29, P361, DOI 10.3109/00365549709011831
   OBrien KD, 1996, ARTERIOSCL THROM VAS, V16, P523, DOI 10.1161/01.ATV.16.4.523
   Otto CM, 2014, NEW ENGL J MED, V371, P744, DOI 10.1056/NEJMra1313875
   OTTO CM, 1994, CIRCULATION, V90, P844, DOI 10.1161/01.CIR.90.2.844
   Owens DS, 2012, JACC-CARDIOVASC IMAG, V5, P619, DOI 10.1016/j.jcmg.2011.12.023
   Pagé A, 2010, J AM COLL CARDIOL, V55, P1867, DOI 10.1016/j.jacc.2009.11.083
   Parikh PB, 2022, J AM HEART ASSOC, V11, DOI 10.1161/JAHA.122.028131
   Parisi V, 2015, NUTR METAB CARDIOVAS, V25, P519, DOI 10.1016/j.numecd.2015.02.001
   Pate GE, 2002, J HEART VALVE DIS, V11, P612
   Piché ME, 2020, CIRC RES, V126, P1477, DOI 10.1161/CIRCRESAHA.120.316101
   Pohle K, 2001, CIRCULATION, V104, P1927, DOI 10.1161/hc4101.097527
   Rabus MB, 2009, J CARDIAC SURG, V24, P146, DOI 10.1111/j.1540-8191.2009.00814.x
   Rajamannan NM, 2011, CIRCULATION, V124, P1783, DOI 10.1161/CIRCULATIONAHA.110.006767
   Reddy P, 2019, CLIN CHIM ACTA, V496, P35, DOI 10.1016/j.cca.2019.06.019
   Rezaeian NH, 2023, IRAN J MED SCI, V48, P370, DOI 10.30476/ijms.2022.94552.2590
   Rieck ÅE, 2012, HYPERTENSION, V60, P90, DOI 10.1161/HYPERTENSIONAHA.112.194878
   Rossebo AB, 2008, NEW ENGL J MED, V359, P1343, DOI 10.1056/NEJMoa0804602
   Schoen FJ, 2008, CIRCULATION, V118, P1864, DOI 10.1161/CIRCULATIONAHA.108.805911
   Senarathne R, 2021, HEALTH SCI REP-US, V4, DOI 10.1002/hsr2.454
   Simmons CA, 2005, CIRC RES, V96, P792, DOI 10.1161/01.RES.0000161998.92009.64
   Smith DB, 2000, ANN BIOMED ENG, V28, P598, DOI 10.1114/1.1306342
   Stålhand J, 2004, BIOMECH MODEL MECHAN, V2, P169, DOI [10.1007/s10237-003-0038-z, 10.1007/S10237-003-0038-z]
   Tanaka M, 2019, CURR HYPERTENS REP, V21, DOI 10.1007/s11906-019-0964-5
   THUBRIKAR M, 1980, CIRC RES, V47, P792, DOI 10.1161/01.RES.47.5.792
   THUBRIKAR MJ, 1986, J THORAC CARDIOV SUR, V92, P29
   Tsimikas S, 2019, CIRC RES, V124, P405, DOI 10.1161/CIRCRESAHA.118.313864
   Tune JD, 2017, TRANSL RES, V183, P57, DOI 10.1016/j.trsl.2017.01.001
   Tylutka A, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-022-27269-6
   Vassallo P, 2016, PROG CARDIOVASC DIS, V59, P172, DOI 10.1016/j.pcad.2016.07.012
   Wedding KL, 2002, J MAGN RESON IMAGING, V15, P418, DOI 10.1002/jmri.10077
   Weinberg EJ, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005960
   Weind KL, 2000, J HEART VALVE DIS, V9, P1
   Youssefi P, 2017, J THORAC CARDIOV SUR, V153, P8, DOI 10.1016/j.jtcvs.2016.09.040
NR 84
TC 0
Z9 0
U1 1
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0032-5481
EI 1941-9260
J9 POSTGRAD MED
JI Postgrad. Med.
PD NOV 16
PY 2024
VL 136
IS 8
BP 810
EP 818
DI 10.1080/00325481.2024.2406740
EA SEP 2024
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA M7I2O
UT WOS:001327443200001
PM 39297302
DA 2025-06-11
ER

PT J
AU Xiao, JL
   Lim, LKE
   Ng, CH
   Tan, DJH
   Lim, WH
   Ho, CSH
   Tan, EXX
   Sanyal, AJ
   Muthiah, MD
AF Xiao, Jieling
   Lim, Lincoln Kai En
   Ng, Cheng Han
   Tan, Darren Jun Hao
   Lim, Wen Hui
   Ho, Cyrus S. H.
   Tan, Eunice Xiang Xuan
   Sanyal, Arun J.
   Muthiah, Mark D.
TI Is Fatty Liver Associated With Depression? A Meta-Analysis and
   Systematic Review on the Prevalence, Risk Factors, and Outcomes of
   Depression and Non-alcoholic Fatty Liver Disease
SO FRONTIERS IN MEDICINE
LA English
DT Review
DE mood disorder; metabolic disease; fatty liver; evidence-based practice;
   mental health
ID Y GASTRIC BYPASS; METABOLIC SYNDROME; BARIATRIC SURGERY; ANXIETY;
   HEALTH; DISORDER; OBESITY; ANTIDEPRESSANTS; INFLAMMATION; CONFIDENCE
AB Background and Aims: Both non-alcoholic fatty liver disease (NAFLD) and depression have a high global prevalence which is projected to increase further. While studies exploring the association have been done, there are conflicting data. This study aims to assess the prevalence and association between depression and NAFLD. Methods: Medline and Embase were searched from inception to March 3, 2020. Meta-analysis of proportions using the generalized linear mix model was conducted to analyze the pooled prevalence of depression in NAFLD patients. Risk factors for depression in NAFLD patients were evaluated in conventional pairwise meta-analysis. Results: Ten studies involving 2,041,752 NAFLD patients were included. Pooled prevalence of depression was 18.21% (CI: 11.12-28.38%) in patients with NAFLD and 40.68% (CI: 25.11-58.37%) in patients with non-alcoholic steatohepatitis (NASH). NAFLD resulted in significantly higher risk of development of depression (OR: 1.29, CI: 1.02-1.64, p = 0.03). NASH patients had a significantly higher risk of depression compared with NAFLD patients (RR: 2.83, CI: 2.41-3.32, p < 0.001). Diabetes, body mass index (BMI), female sex, smoking, and history of pulmonary disease were significant risk factors for depression in NAFLD patients. Conclusion: This study demonstrated a high prevalence of depression in NAFLD patients and a significant association between both conditions. Furthermore, patients with NASH had a significantly higher risk of depression compared with those with NAFLD. Diabetes, BMI, history of lung disease or smoking, and female gender were significant risk factors. Further studies investigating the pathophysiological mechanism underlying depression and NAFLD are needed.
C1 [Xiao, Jieling; Lim, Lincoln Kai En; Ng, Cheng Han; Tan, Darren Jun Hao; Lim, Wen Hui; Ho, Cyrus S. H.; Tan, Eunice Xiang Xuan; Muthiah, Mark D.] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore.
   [Ho, Cyrus S. H.] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Singapore, Singapore.
   [Tan, Eunice Xiang Xuan; Muthiah, Mark D.] Natl Univ Hlth Syst, Natl Univ Ctr Organ Transplantat, Singapore, Singapore.
   [Tan, Eunice Xiang Xuan; Muthiah, Mark D.] Natl Univ Singapore Hosp, Dept Med, Div Gastroenterol & Hepatol, Singapore, Singapore.
   [Sanyal, Arun J.] Virginia Commonwealth Univ, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, Richmond, VA USA.
C3 National University of Singapore; National University of Singapore;
   National University of Singapore; National University of Singapore;
   Virginia Commonwealth University
RP Ng, CH; Muthiah, MD (corresponding author), Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore.; Muthiah, MD (corresponding author), Natl Univ Hlth Syst, Natl Univ Ctr Organ Transplantat, Singapore, Singapore.; Muthiah, MD (corresponding author), Natl Univ Singapore Hosp, Dept Med, Div Gastroenterol & Hepatol, Singapore, Singapore.
EM chenhanng@gmail.com; mdcmdm@nus.edu.sg
RI Ho, Cyrus SH/AAN-9344-2020; Ng, Cheng Han/IWU-3648-2023
OI Tan, Eunice/0000-0002-3757-4986; Lim, Lincoln/0000-0002-5131-3109; Ho,
   Cyrus SH/0000-0002-7092-9566
CR Backman O, 2016, BRIT J SURG, V103, P1336, DOI 10.1002/bjs.10258
   Balp MM, 2019, JHEP REP, V1, P154, DOI 10.1016/j.jhepr.2019.05.009
   Borenstein M, 2017, RES SYNTH METHODS, V8, P5, DOI 10.1002/jrsm.1230
   Caiazzo R, 2014, ANN SURG, V260, P893, DOI 10.1097/SLA.0000000000000945
   Chan KL, 2019, PHYSIOLOGY, V34, P123, DOI 10.1152/physiol.00047.2018
   Cho IY, 2021, EPIDEMIOL PSYCH SCI, V30, DOI 10.1017/S204579602000116X
   Choi JM, 2021, FRONT MED-LAUSANNE, V7, DOI 10.3389/fmed.2020.585618
   Clopper CJ, 1934, BIOMETRIKA, V26, P404, DOI 10.2307/2331986
   Comino EJ, 2001, FAM PRACT, V18, P71, DOI 10.1093/fampra/18.1.71
   DERSIMONIAN R, 1986, CONTROL CLIN TRIALS, V7, P177, DOI 10.1016/0197-2456(86)90046-2
   Diabetes Prevention Program Research Group, 2009, Lancet, V374, P1677, DOI 10.1016/S0140-6736(09)61457-4
   Egede LE, 2002, DIABETES CARE, V25, P464, DOI 10.2337/diacare.25.3.464
   Elwing JE, 2006, PSYCHOSOM MED, V68, P563, DOI 10.1097/01.psy.0000221276.17823.df
   Engel SG, 2009, INT J EAT DISORDER, V42, P179, DOI 10.1002/eat.20602
   Fan JG, 2017, J HEPATOL, V67, P862, DOI 10.1016/j.jhep.2017.06.003
   FERNANDEZ M, 2020, ANN HEPATOL, V22, P277, DOI DOI 10.1016/J.AOHEP.2020.10.005
   Finelli C, 2013, WORLD J GASTROENTERO, V19, P802, DOI 10.3748/wjg.v19.i6.802
   Fletcher J, 2007, BMJ-BRIT MED J, V334, P94, DOI 10.1136/bmj.39057.406644.68
   Gafoor R, 2018, BMJ-BRIT MED J, V361, DOI 10.1136/bmj.k1951
   Gawlik-Kotelnicka O, 2021, LIFE-BASEL, V11, DOI 10.3390/life11020117
   Gehrke N, 2020, GASTROENTEROLOGY, V158, P1929, DOI 10.1053/j.gastro.2020.02.020
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Goodwin RD, 2012, NICOTINE TOB RES, V14, P176, DOI 10.1093/ntr/ntr165
   Harris RJ, 2008, STATA J, V8, P3, DOI 10.1177/1536867X0800800102
   Hassan AM, 2019, NUTR NEUROSCI, V22, P877, DOI 10.1080/1028415X.2018.1465713
   Herrman H, 2019, LANCET, V393, pE42, DOI 10.1016/S0140-6736(18)32408-5
   Huang DQ, 2020, HEPATOL COMMUN, V4, P1624, DOI 10.1002/hep4.1593
   Hunter JP, 2014, J CLIN EPIDEMIOL, V67, P897, DOI 10.1016/j.jclinepi.2014.03.003
   Ismail Z, 2017, JAMA PSYCHIAT, V74, P58, DOI 10.1001/jamapsychiatry.2016.3162
   Jung JY, 2019, J KOREAN MED SCI, V34, DOI 10.3346/jkms.2019.34.e199
   KATZ D, 1978, BIOMETRICS, V34, P469, DOI 10.2307/2530610
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Koo CH, 2020, DIS COLON RECTUM, V63, P701, DOI 10.1097/DCR.0000000000001664
   Labenz C, 2020, HEPATOL COMMUN, V4, P1293, DOI 10.1002/hep4.1541
   Laursen TL, 2019, WORLD J HEPATOL, V11, P138, DOI 10.4254/wjh.v11.i2.138
   Lee K, 2013, PSYCHOSOMATICS, V54, P52, DOI 10.1016/j.psym.2012.09.005
   Lee Y, 2019, CLIN GASTROENTEROL H, V17, P1040, DOI 10.1016/j.cgh.2018.10.017
   Liu QQ, 2020, J PSYCHIATR RES, V126, P134, DOI 10.1016/j.jpsychires.2019.08.002
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Lustman PJ, 2005, J DIABETES COMPLICAT, V19, P113, DOI 10.1016/j.jdiacomp.2004.01.002
   Ma QY, 2021, HEPATOL INT, V15, P127, DOI 10.1007/s12072-020-10132-z
   Malhi GS, 2018, LANCET, V392, P2299, DOI 10.1016/S0140-6736(18)31948-2
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Moieni M, 2015, NEUROPSYCHOPHARMACOL, V40, P1709, DOI 10.1038/npp.2015.17
   Moretti R, 2019, ANN HEPATOL, V18, P563, DOI 10.1016/j.aohep.2019.04.007
   Moussavi S, 2007, LANCET, V370, P851, DOI 10.1016/S0140-6736(07)61415-9
   Munn Z, 2014, INT J HEALTH POLICY, V3, P123, DOI 10.15171/ijhpm.2014.71
   Neuschwander-Tetri BA, 2017, BMC MED, V15, DOI 10.1186/s12916-017-0806-8
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Parletta N, 2019, NUTR NEUROSCI, V22, P474, DOI 10.1080/1028415X.2017.1411320
   Patel V, 2016, LANCET, V387, P1672, DOI 10.1016/S0140-6736(15)00390-6
   Penninx BWJH, 2001, ARCH GEN PSYCHIAT, V58, P221, DOI 10.1001/archpsyc.58.3.221
   Quattrocki E, 2000, HARVARD REV PSYCHIAT, V8, P99, DOI 10.1093/hrp/8.3.99
   Raison CL, 2006, TRENDS IMMUNOL, V27, P24, DOI 10.1016/j.it.2005.11.006
   Rinella ME, 2015, JAMA-J AM MED ASSOC, V313, P2263, DOI 10.1001/jama.2015.5370
   Roriz-Cruz M, 2007, J AM GERIATR SOC, V55, P374, DOI 10.1111/j.1532-5415.2007.01068.x
   Rücker G, 2008, BMC MED RES METHODOL, V8, DOI 10.1186/1471-2288-8-79
   Sayiner M, 2020, HEPATOL INT, V14, P556, DOI 10.1007/s12072-020-10038-w
   Schwarzer G, 2019, RES SYNTH METHODS, V10, P476, DOI 10.1002/jrsm.1348
   Sedgwick P, 2015, BMJ-BRIT MED J, V351, DOI 10.1136/bmj.h4419
   Sharafi SE., 2020, Obesity Medicine, V17, P100169, DOI DOI 10.1016/J.OBMED.2019.100169
   Simon GE, 2008, GEN HOSP PSYCHIAT, V30, P32, DOI 10.1016/j.genhosppsych.2007.09.001
   Steffen KJ, 2015, EUR EAT DISORD REV, V23, P442, DOI 10.1002/erv.2399
   Stevens VJ, 2001, ANN INTERN MED, V134, P1, DOI 10.7326/0003-4819-134-1-200101020-00007
   Surdea-Blaga Teodora, 2011, Rom J Intern Med, V49, P273
   Tomeno W, 2015, J GASTROEN HEPATOL, V30, P1009, DOI 10.1111/jgh.12897
   Weinstein AA, 2011, PSYCHOSOMATICS, V52, P127, DOI 10.1016/j.psym.2010.12.019
   Ye Q, 2020, LANCET GASTROENTEROL, V5, P739, DOI 10.1016/S2468-1253(20)30077-7
   Youssef NA, 2013, LIVER INT, V33, P1062, DOI 10.1111/liv.12165
   Zhou XY, 2020, LANCET PSYCHIAT, V7, P581, DOI 10.1016/S2215-0366(20)30137-1
NR 70
TC 57
Z9 57
U1 0
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD JUN 30
PY 2021
VL 8
AR 691696
DI 10.3389/fmed.2021.691696
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA TJ1FM
UT WOS:000673236600001
PM 34277666
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Happell, B
   Platania-Phung, C
   Scott, D
AF Happell, Brenda
   Platania-Phung, Chris
   Scott, David
TI Are Nurses in Mental Health Services Providing Physical Health Care for
   People with Serious Mental Illness? An Australian Perspective
SO ISSUES IN MENTAL HEALTH NURSING
LA English
DT Article
ID LIFE-STYLE INTERVENTION; SEXUAL HEALTH; METABOLIC SYNDROME;
   CIGARETTE-SMOKING; CO-MORBIDITY; SCHIZOPHRENIA; BARRIERS; WEIGHT;
   DEPRESSION; DISORDERS
AB People with serious mental illness are at high-risk for physical illnesses and premature death, and nurses can contribute to ensuring mental health services address these risks. There is very little research examining the role of nurses in mental health who provide physical health care. To identify the levels of participation in physical health care of people with serious mental illness (SMI), a national Internet-based survey of nurses working in mental health in Australia was conducted (n = 643). The survey included an adapted version of the Robson and Haddad Physical Health Attitude Scale. Data were analysed through comparison of frequencies, correlations, principal components analysis, and Mann-Whitney tests. Nurses reported regular physical health care in 12 of the 17 tasks presented to them. The three most common self-reported physical health care activities were inquiring about consumers' contact with GPs, doing physical assessments, and providing information on drug use and lifestyle. Although some practices were less common (e.g., contraceptive advice) nurses who provided one type of care tended to do other types as well. In addition, credentialing in mental health nursing was associated with slightly more regular engagement in all practice domains except screening and assessments. Nurses in mental health in Australia may be engaged in improving physical health of consumers with SMI more than is assumed.
C1 Cent Queensland Univ, Inst Hlth & Social Sci Res, Ctr Mental Hlth Nursing Innovat, Rockhampton, Qld 4702, Australia.
   Cent Queensland Univ, Sch Nursing & Midwifery, Rockhampton, Qld 4702, Australia.
C3 Central Queensland University; Central Queensland University
RP Happell, B (corresponding author), CQ Univ Australia, Inst Hlth & Social Sci Res, Rockhampton, Qld 4701, Australia.
EM b.happell@cqu.edu.au
RI Scott, David/AAE-5031-2021; Happell, Brenda/HSI-0570-2023
OI Scott, David/0000-0001-5226-1972; Happell, Brenda/0000-0002-7293-6583
CR Australian College of Mental Health Nurses, 2012, CRED PRACT PROGR
   Barre LK, 2011, PSYCHIATR REHABIL J, V34, P304, DOI 10.2975/34.4.2011.304.310
   Bartels SJ, 2009, CURR OPIN PSYCHIATR, V22, P381, DOI 10.1097/YCO.0b013e32832c9234
   Blythe J, 2012, INT J MENT HEALTH NU, V21, P193, DOI 10.1111/j.1447-0349.2011.00792.x
   Bradford DW, 2008, PSYCHIAT SERV, V59, P847, DOI 10.1176/ps.2008.59.8.847
   Bradshaw T, 2010, J PSYCHIATR MENT HLT, V17, P473, DOI 10.1111/j.1365-2850.2009.01543.x
   Bradshaw T, 2012, INT J MENT HEALTH NU, V21, P266, DOI 10.1111/j.1447-0349.2012.00818.x
   Brown S, 2010, BRIT J PSYCHIAT, V196, P116, DOI 10.1192/bjp.bp.109.067512
   Brunero S, 2009, INT J MENT HEALTH NU, V18, P144, DOI 10.1111/j.1447-0349.2009.00595.x
   Chadwick A, 2012, INT J MENT HEALTH NU, V21, P211, DOI 10.1111/j.1447-0349.2011.00807.x
   Compton MT, 2006, HARVARD REV PSYCHIAT, V14, P212, DOI 10.1080/10673220600889256
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P138
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   De Hert M, 2009, WORLD PSYCHIATRY, V8, P15
   Frayne SM, 2004, ARCH INTERN MED, V164, P1306, DOI 10.1001/archinte.164.12.1306
   Gill KJ, 2009, J REHABIL, V75, P32
   Gray R, 2012, INT J MENT HEALTH NU, V21, P191, DOI 10.1111/j.1447-0349.2012.00832.x
   Happell B, 2011, J PSYCHIATR MENT HLT, V18, P706, DOI 10.1111/j.1365-2850.2010.01666.x
   Happell B, 2011, INT J MENT HEALTH NU, V20, P310, DOI 10.1111/j.1447-0349.2010.00732.x
   Happell B, 2012, INT J MENT HEALTH NU, V21, P202, DOI 10.1111/j.1447-0349.2011.00799.x
   Higgins A, 2006, J PSYCHIATR MENT HLT, V13, P687, DOI 10.1111/j.1365-2850.2006.01016.x
   Howard L, 2011, J PSYCHIATR MENT HLT, V18, P105, DOI 10.1111/j.1365-2850.2010.01642.x
   Hyland B, 2003, AUST NZ J PSYCHIAT, V37, P710, DOI 10.1111/j.1440-1614.2003.01264.x
   Jacobi F, 2004, PSYCHOL MED, V34, P597, DOI 10.1017/S0033291703001399
   Lawrence D, 2010, J PSYCHOPHARMACOL, V24, P61, DOI 10.1177/1359786810382058
   Lee SJ, 2008, J CLIN PSYCHIAT, V69, P555, DOI 10.4088/JCP.v69n0406
   Lindenmayer JP, 2009, J CLIN PSYCHIAT, V70, P1385, DOI 10.4088/JCP.08m04740yel
   Manderscheid RW, 2009, INT J PUBLIC HEALTH, V54, P7, DOI 10.1007/s00038-009-7076-y
   Marks P., 2012, NEWS AUSTR COLL  JUN
   McCandless F, 2003, J ADV NURS, V44, P42, DOI 10.1046/j.1365-2648.2003.02766.x
   McCloughen A, 2003, INT J MENT HEALTH NU, V12, P119, DOI 10.1046/j.1440-0979.2003.00278.x
   McCloughen A, 2011, INT J MENT HEALTH NU, V20, P202, DOI 10.1111/j.1447-0349.2010.00721.x
   Moussavi S, 2007, LANCET, V370, P851, DOI 10.1016/S0140-6736(07)61415-9
   Muir-Cochrane E, 2006, J PSYCHIATR MENT HLT, V13, P447, DOI 10.1111/j.1365-2850.2006.01002.x
   Park T, 2011, INT J MENT HEALTH NU, V20, P428, DOI 10.1111/j.1447-0349.2011.00747.x
   Porsdal V, 2010, BMC PSYCHIATRY, V10, DOI 10.1186/1471-244X-10-42
   Quinn C, 2011, INT J MENT HEALTH NU, V20, P21, DOI 10.1111/j.1447-0349.2010.00705.x
   Robson D, 2007, INT J NURS STUD, V44, P457, DOI 10.1016/j.ijnurstu.2006.07.013
   Robson D, 2012, INT J NURS STUD, V49, P72, DOI 10.1016/j.ijnurstu.2011.07.011
   Rummel-Kluge C, 2010, SCHIZOPHR RES, V123, P225, DOI 10.1016/j.schres.2010.07.012
   Saha S, 2007, ARCH GEN PSYCHIAT, V64, P1123, DOI 10.1001/archpsyc.64.10.1123
   Scott David, 2011, Issues Ment Health Nurs, V32, P589, DOI 10.3109/01612840.2011.569846
   Smith S, 2007, EUR PSYCHIAT, V22, P413, DOI 10.1016/j.eurpsy.2007.07.002
   Tschoner A, 2007, INT J CLIN PRACT, V61, P1356, DOI 10.1111/j.1742-1241.2007.01416.x
   Vancampfort D, 2012, ACTA PSYCHIAT SCAND, V125, P352, DOI 10.1111/j.1600-0447.2011.01814.x
   Vreeland B, 2007, J CLIN PSYCHIAT, V68, P26
NR 46
TC 22
Z9 22
U1 0
U2 10
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0161-2840
EI 1096-4673
J9 ISSUES MENT HEALTH N
JI Issues Ment. Health Nurs.
PD MAR
PY 2013
VL 34
IS 3
BP 198
EP 207
DI 10.3109/01612840.2012.733907
PG 10
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA V38TP
UT WOS:000209366000009
PM 23477441
DA 2025-06-11
ER

PT J
AU Warner, JO
AF Warner, John O.
TI Artificial food additives: hazardous to long-term health?
SO ARCHIVES OF DISEASE IN CHILDHOOD
LA English
DT Review
DE Obesity; Child Health; Mental health; Toxicology
ID HISTAMINE-RELEASE; DOUBLE-BLIND; HYPERACTIVITY; CHILDREN
AB Many additives, some of which have no nutritional value, can be legally used in processed foods. They intensify colour, thicken, increase shelf life and enhance flavour. Regulatory authorities issue approvals as safe within acceptable quantitative limits. Ultra-processed foods (UPFs) contain combinations of all these additives and are particularly attractive to children.
   Many publications suggest that artificial colourants, benzoate preservatives, non-caloric sweeteners, emulsifiers and their degradation derivatives have adverse effects by increasing risks of mental health disorders, attention deficit hyperactivity disorder, cardiovascular disease, metabolic syndrome and potential carcinogenic effects.
   A systematic review has established that artificial azo dye food colourants (AFCs) and sodium benzoate preservative cause disturbed behaviour in children. AFCs and benzoates in animal models have neurotoxic properties through gut microbial generation of toxic metabolites. Observational studies show associations between high emulsifier intake and cardiovascular disease. Animal models and in vitro studies have highlighted neurotoxic, cytotoxic, genotoxic and carcinogenic effects. High intake of non-caloric sweeteners has been linked to cardiovascular disease and depression in adults and is linked to childhood obesity.
   Little research has focused on children who are the largest consumers of UPFs. Potentially, they are a ticking time bomb for adult obesity, metabolic syndrome, cardiovascular diseases, mental health disorders and cancers. Based on risk/benefit analysis, azo dye AFCs should be banned. Benzoates, emulsifiers and sweeteners require assessment of quantitative limits and cumulative effects of combinations. Consumers purchasing UPFs require information through ingredient health warnings and recommendations to use natural unprocessed foods which have well-described health-promoting properties.
C1 [Warner, John O.] Imperial Coll London, Natl Heart & Lung Inst, Inflammat Repair & Dev Sect, Fac Med, London, England.
C3 Imperial College London
RP Warner, JO (corresponding author), Imperial Coll London, Natl Heart & Lung Inst, Inflammat Repair & Dev Sect, Fac Med, London, England.
EM j.o.warner@imperial.ac.uk
RI Warner, John/AAF-9587-2020
OI Warner, John/0000-0001-7123-6369
FU Food Standards Agency (UK)
FX While I had no funding to produce this manuscript, the challenge studies
   performed by my group and reported in the paper were funded by grants
   from the Food Standards Agency (UK).
CR Ahmed MA, 2023, J KING SAUD UNIV SCI, V35, DOI 10.1016/j.jksus.2023.102596
   Andreozzi Laura, 2019, Acta Biomed, V90, P80, DOI 10.23750/abm.v90i3-S.8168
   [Anonymous], 2008, EFSA J, V6, DOI 10.2903/j.efsa.2008.660
   Bateman B, 2004, ARCH DIS CHILD, V89, P506, DOI 10.1136/adc.2003.031435
   Buchanan KL, 2022, NAT NEUROSCI, V25, P191, DOI 10.1038/s41593-021-00982-7
   Calcaterra V, 2023, CHILDREN-BASEL, V10, DOI 10.3390/children10050804
   Debras C, 2022, BMJ-BRIT MED J, V378, DOI 10.1136/bmj-2022-071204
   Elmén L, 2020, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.00892
   Feingold B F, 1975, Am J Nurs, V75, P797, DOI 10.2307/3423460
   Guasch-Ferré M, 2021, J INTERN MED, V290, P549, DOI 10.1111/joim.13333
   Kemp A, 2008, BMJ-BRIT MED J, V336, P1144, DOI 10.1136/bmj.39582.375336.BE
   Koh A, 2020, MOL CELL, V78, P584, DOI 10.1016/j.molcel.2020.03.005
   McCann D, 2007, LANCET, V370, P1560, DOI 10.1016/S0140-6736(07)61306-3
   Monteiro CD, 2023, FOOD ADDIT CONTAM A, V40, P613, DOI 10.1080/19440049.2023.2203778
   Mortz CG, 2022, CLIN TRANSL ALLERGY, V12, DOI 10.1002/clt2.12111
   MURDOCH RD, 1987, J ROY COLL PHYS LOND, V21, P257
   MURDOCH RD, 1987, J ROY COLL PHYS LOND, V21, P251
   Naganuma F, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-16019-8
   Partridge D, 2019, NUTR BULL, V44, P329, DOI 10.1111/nbu.12408
   Renita AA, 2023, FOODS, V12, DOI 10.3390/foods12071521
   Sambu S, 2022, BIOMED RES INT, V2022, DOI 10.1155/2022/6829409
   Samuthpongtorn C, 2023, JAMA NETW OPEN, V6, DOI 10.1001/jamanetworkopen.2023.34770
   Scammell TE, 2019, SLEEP, V42, DOI 10.1093/sleep/zsy183
   Schab DW, 2004, J DEV BEHAV PEDIATR, V25, P423, DOI 10.1097/00004703-200412000-00007
   Sellem L, 2023, BMJ-BRIT MED J, V382, DOI 10.1136/bmj-2023-076058
   Srour B, 2022, LANCET GASTROENTEROL, V7, P1128, DOI 10.1016/S2468-1253(22)00169-8
   Stevenson J, 2010, AM J PSYCHIAT, V167, P1108, DOI 10.1176/appi.ajp.2010.09101529
   Szopa A, 2021, PHARMACOL THERAPEUT, V224, DOI 10.1016/j.pharmthera.2021.107821
   Touvier M, 2023, BMJ-BRIT MED J, V383, DOI 10.1136/bmj-2023-075294
NR 29
TC 10
Z9 10
U1 37
U2 80
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0003-9888
EI 1468-2044
J9 ARCH DIS CHILD
JI Arch. Dis. Child.
PD NOV 1
PY 2024
VL 109
IS 11
BP 882
EP 885
DI 10.1136/archdischild-2023-326565
EA FEB 2024
PG 4
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA M8M6O
UT WOS:001181903200001
PM 38423749
DA 2025-06-11
ER

PT J
AU Ikeda, A
   Steptoe, A
   Brunner, EJ
   Maruyama, K
   Tomooka, K
   Kato, T
   Miyoshi, N
   Nishioka, S
   Saito, I
   Tanigawa, T
AF Ikeda, Ai
   Steptoe, Andrew
   Brunner, Eric J.
   Maruyama, Koutatsu
   Tomooka, Kiyohide
   Kato, Tadahiro
   Miyoshi, Noriko
   Nishioka, Shinji
   Saito, Isao
   Tanigawa, Takeshi
TI Salivary Alpha-Amylase Activity in Relation to Cardiometabolic Status in
   Japanese Adults without History of Cardiovascular Disease
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Article
DE Salivary alpha-amylase activity; Glucose intolerance; Insulin
   resistance; Blood pressure
ID HEART-RATE-VARIABILITY; TYPE-2 DIABETES-MELLITUS; FASTING
   PLASMA-GLUCOSE; STRESS-INDUCED CHANGES; INSULIN-RESISTANCE;
   GENDER-DIFFERENCES; PSYCHOLOGICAL STRESS; SOCIOECONOMIC-STATUS;
   METABOLIC SYNDROME; SEX-DIFFERENCES
AB Aims: Stress is known to be a potential contributor to the development of diabetes and hypertension. However, the biological mechanisms underlying the association between cardiometabolic risk markers and the biological stress response have not yet been determined. Therefore, we examined salivary alpha-amylase and heart rate variability in relation to cardiometabolic status in a sample of healthy Japanese men and women.
   Methods: Participants (473 men and 1,029 women aged 30-84) underwent a 75 g oral glucose tolerance test after a 10-hr fast. The homeostasis model assessment index for insulin resistance was based on fasting and 2-hr postload glucose and insulin concentrations. Sitting blood pressure was measured twice after rest. A saliva sample was collected in the morning and salivary alpha-amylase was assayed. A 5-min heart rate variability recording was evaluated using time-domain indices of standard deviations of normal-to-normal intervals and root mean square of successive differences. Multivariate linear regression models were used to estimate associations between salivary alpha-amylase and each outcome measure.
   Results: Salivary alpha-amylase was associated with fasting glucose (beta = 0.008; 95% CI = 0.002, 0.014), 2-hr postload glucose (beta = 0.023; 95% CI = 0.004, 0.041), homeostasis model assessment index for insulin resistance (beta = 0.032; 95%CI = 0.000, 0.064), systolic (beta = 1.603; 95% CI = 0.479, 2.726) and diastolic (beta = 0.906; 95% CI = 0.212, 1.600) blood pressures among women. These associations remained significant after further adjustment for heart rate variability measures.
   Conclusions: The elevation of salivary alpha-amylase may reflect a dysfunction of the sympathetic nervous system associated with cardiometabolic abnormalities in women.
C1 [Ikeda, Ai; Tomooka, Kiyohide; Miyoshi, Noriko; Tanigawa, Takeshi] Juntendo Univ, Dept Publ Hlth, Grad Sch Med, Tokyo, Japan.
   [Ikeda, Ai; Steptoe, Andrew; Brunner, Eric J.] UCL, Fac Populat Hlth Sci, Dept Epidemiol & Publ Hlth, London, England.
   [Maruyama, Koutatsu; Nishioka, Shinji] Ehime Univ, Grad Sch Agr, Dept Biosci, Lab Community Hlth & Nutr,Special Course Food & H, Matsuyama, Ehime, Japan.
   [Kato, Tadahiro] Ehime Univ, Fac Educ, Ctr Educ & Educ Res, Matsuyama, Ehime, Japan.
   [Nishioka, Shinji] Ehime Dent Assoc, Matsuyama, Ehime, Japan.
   [Saito, Isao] Oita Univ, Fac Med, Dept Publ Hlth & Epidemiol, Yufu, Japan.
C3 Juntendo University; University of London; University College London;
   Ehime University; Ehime University; Oita University
RP Tanigawa, T (corresponding author), Juntendo Univ, Dept Publ Hlth, Grad Sch Med, Bunkyo Ku, 2-1-1 Hongo, Tokyo 1138421, Japan.
EM tataniga@juntendo.ac.jp
RI Brunner, Eric/H-2114-2011; Steptoe, Andrew/Y-2440-2019
OI Brunner, Eric/0000-0002-0595-4474
FU JSPS KAKENHI [JP16K09072, JP17KK0175, JP18H03056, JP18K10087,
   JP17K00881]; MRC [MR/R024227/1] Funding Source: UKRI
FX This study was supported by JSPS KAKENHI Grant Numbers; JP16K09072,
   JP17KK0175, JP18H03056, JP18K10087, JP17K00881.
CR Ainsworth BE, 2000, MED SCI SPORT EXER, V32, pS498, DOI 10.1097/00005768-200009001-00009
   Baum A, 1999, ANN NY ACAD SCI, V896, P131, DOI 10.1111/j.1749-6632.1999.tb08111.x
   Billman GE, 2013, FRONT PHYSIOL, V4, DOI 10.3389/fphys.2013.00026
   Bosch JA, 2003, PSYCHOSOM MED, V65, P245, DOI 10.1097/01.PSY.0000058376.50240.2D
   Bosch JA, 1996, PSYCHOSOM MED, V58, P374, DOI 10.1097/00006842-199607000-00010
   Brebner J, 2003, PERS INDIV DIFFER, V34, P387, DOI 10.1016/S0191-8869(02)00059-4
   Chang CJ, 2010, AM J MED, V123, P432, DOI 10.1016/j.amjmed.2009.07.031
   Danaei G, 2011, LANCET, V378, P31, DOI 10.1016/S0140-6736(11)60679-X
   Eriksson AK, 2013, DIABETES CARE, V36, P2683, DOI 10.2337/dc12-1738
   FEINGOLD A, 1994, PSYCHOL BULL, V116, P429, DOI 10.1037/0033-2909.116.3.429
   Fischer AH, 2004, EMOTION, V4, P87, DOI 10.1037/1528-3542.4.1.87
   GIRDLER SS, 1990, PSYCHOSOM MED, V52, P571, DOI 10.1097/00006842-199009000-00009
   Hackett RA, 2017, NAT REV ENDOCRINOL, V13, P547, DOI 10.1038/nrendo.2017.64
   Heraclides A, 2009, DIABETES CARE, V32, P2230, DOI 10.2337/dc09-0132
   Higuchi K, 2015, NUTRITION, V31, P975, DOI 10.1016/j.nut.2015.02.015
   Honjo K, 2014, INT J BEHAV MED, V21, P421, DOI 10.1007/s12529-013-9309-y
   HURWITZ BE, 1993, BIOL PSYCHOL, V36, P75, DOI 10.1016/0301-0511(93)90082-J
   Inoue A, 2010, J OCCUP HEALTH, V52, P227, DOI 10.1539/joh.O10002
   Ishikawa-Takata K, 2011, J EPIDEMIOL, V21, P114, DOI 10.2188/jea.JE20100079
   Iso H, 2002, CIRCULATION, V106, P1229, DOI 10.1161/01.CIR.0000028145.58654.41
   Kang Y, 2010, NURS HEALTH SCI, V12, P477, DOI 10.1111/j.1442-2018.2010.00562.x
   Kelly MM, 2008, J BEHAV THER EXP PSY, V39, P87, DOI 10.1016/j.jbtep.2007.02.003
   Low CA, 2010, PSYCHOSOM MED, V72, P842, DOI 10.1097/PSY.0b013e3181f6934f
   Mandel AL, 2012, J NUTR, V142, P853, DOI 10.3945/jn.111.156984
   Mangmool S, 2016, MOL ENDOCRINOL, V30, P118, DOI 10.1210/me.2015-1201
   Manolis AJ, 2014, CURR VASC PHARMACOL, V12, P4
   Marquina C., 2019, J CLIN MED, P8
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McCurley JL, 2015, PSYCHOPHYSIOLOGY, V52, P1071, DOI 10.1111/psyp.12430
   Miyoshi N, 2018, J PERIODONTAL RES, V53, P487, DOI 10.1111/jre.12537
   Mommersteeg PMC, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-1109
   Nater UM, 2009, PSYCHONEUROENDOCRINO, V34, P486, DOI 10.1016/j.psyneuen.2009.01.014
   Nater UM, 2006, PSYCHONEUROENDOCRINO, V31, P49, DOI 10.1016/j.psyneuen.2005.05.010
   Novak M, 2013, DIABETIC MED, V30, pE8, DOI 10.1111/dme.12037
   OLSEN PS, 1988, DIGESTION, V41, P34, DOI 10.1159/000199729
   PAGANI M, 1986, CIRC RES, V59, P178, DOI 10.1161/01.RES.59.2.178
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Rannelli LA, 2017, CAN J PHYSIOL PHARM, V95, P349, DOI 10.1139/cjpp-2016-0122
   Saito I, 2018, AM J HYPERTENS, V31, P1120, DOI 10.1093/ajh/hpy100
   Saito I, 2017, CIRC J, V81, P1447, DOI 10.1253/circj.CJ-17-0192
   Saito I, 2012, CIRC J, V76, P1066, DOI 10.1253/circj.CJ-11-1519
   Sánchez GA, 2011, J PERIODONTAL RES, V46, P221, DOI 10.1111/j.1600-0765.2010.01332.x
   Schroeder EB, 2005, DIABETES CARE, V28, P668, DOI 10.2337/diacare.28.3.668
   Shaffer F, 2017, FRONT PUBLIC HEALTH, V5, DOI 10.3389/fpubh.2017.00258
   Siddiqui A, 2015, STRESS, V18, P498, DOI 10.3109/10253890.2015.1067677
   Singh JP, 1998, HYPERTENSION, V32, P293, DOI 10.1161/01.HYP.32.2.293
   SPEIRS RL, 1974, ARCH ORAL BIOL, V19, P747, DOI 10.1016/0003-9969(74)90161-7
   STONE SV, 1990, J BEHAV MED, V13, P137, DOI 10.1007/BF00844995
   SURWIT RS, 1992, DIABETES CARE, V15, P1413, DOI 10.2337/diacare.15.10.1413
   Tomova L, 2014, PSYCHONEUROENDOCRINO, V43, P95, DOI 10.1016/j.psyneuen.2014.02.006
   van Stegeren A, 2006, PSYCHONEUROENDOCRINO, V31, P137, DOI 10.1016/j.psyneuen.2005.05.012
   Zellner DA, 2006, PHYSIOL BEHAV, V87, P789, DOI 10.1016/j.physbeh.2006.01.014
NR 52
TC 5
Z9 5
U1 0
U2 5
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PY 2021
VL 28
IS 8
BP 852
EP 864
DI 10.5551/jat.53926
PG 13
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA TU1KO
UT WOS:000680798800009
PM 33041312
OA Green Published, gold
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Alessi, MC
   Juhan-Vague, I
AF Alessi, Marie-Christine
   Juhan-Vague, Irene
TI Metabolic syndrome, haemostasis and thrombosis
SO THROMBOSIS AND HAEMOSTASIS
LA English
DT Review
DE haemostasis; metabolic syndrome; visceral obesity; platelet;
   coagulation; fibrinolysis; endothelial dysfunction
ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; DEPENDENT PLATELET-AGGREGATION;
   NUTRITIONALLY INDUCED OBESITY; ADIPOSE-TISSUE DEVELOPMENT;
   CORONARY-ARTERY-DISEASE; FACTOR GENE-EXPRESSION; INSULIN-RESISTANCE;
   ENDOTHELIAL DYSFUNCTION; VENOUS THROMBOEMBOLISM; RISK-FACTORS
AB The metabolic syndrome (metS), a concurrence of abdominal fat, disturbed glucose and insulin metabolism, dyslipidemia, and hypertension has been strongly associated not only with subsequent development of type 2 diabetes but also with atherothrombosis. The physiopathology of this association is complex. The metS affects the thrombogenicity of circulating blood. Apart from its effect on platelets, a procoagulant and hypofibrinolytic state has been identified; mainly the result of the inflammatory state, dyslipidemia,and liver fat accumulation that accompany the MetS. Among haemostasis disturbances, the strong rise in the inhibitor of plasminogen activator type I plasma level is the most documented abnormality implicating the participation of the oxidative stress and inflammatory state developed during the metS. Endothelial dysfunction is also a central feature. Moreover, secretion products of fat tissues (adipokines) are now thought to have direct modulating effects on the vascular and the circulating cells. In support of these data, the metS, may predispose not only to atherosclerosis but also to venous thrombosis.
C1 [Alessi, Marie-Christine; Juhan-Vague, Irene] Univ Mediterranee, Hematol Lab, Fac Med, Inserm UMR 626, F-13385 Marseille, France.
C3 Aix-Marseille Universite; Institut National de la Sante et de la
   Recherche Medicale (Inserm)
RP Alessi, MC (corresponding author), Univ Mediterranee, Hematol Lab, Fac Med, Inserm UMR 626, 27 Bd Jean Moulin, F-13385 Marseille, France.
EM marie-christine.alessi@univmed.fr
RI ALESSI, Marie-christine/AAK-3582-2020
OI ALESSI, Marie-christine/0000-0003-3927-5792
CR Abbasi F, 2002, J AM COLL CARDIOL, V40, P937, DOI 10.1016/S0735-1097(02)02051-X
   Ageno W, 2006, J THROMB HAEMOST, V4, P1914, DOI 10.1111/j.1538-7836.2006.02132.x
   Ageno W, 2008, CIRCULATION, V117, P93, DOI 10.1161/CIRCULATIONAHA.107.709204
   Alessi MC, 2006, ARTERIOSCL THROM VAS, V26, P2200, DOI 10.1161/01.ATV.0000242905.41404.68
   Alessi MC, 2003, ARTERIOSCL THROM VAS, V23, P1262, DOI 10.1161/01.ATV.0000077401.36885.BB
   Alessi MC, 1997, DIABETES, V46, P860, DOI 10.2337/diabetes.46.5.860
   Anfossi G, 2006, CURR DIABETES REV, V2, P409, DOI 10.2174/1573399810602040409
   Anfossi Giovanni, 2006, Cardiovascular & Hematological Agents in Medicinal Chemistry, V4, P111, DOI 10.2174/187152506776369908
   Angiolillo DJ, 2005, DIABETES, V54, P2430, DOI 10.2337/diabetes.54.8.2430
   Angiolillo DJ, 2007, CIRCULATION, V115, P708, DOI 10.1161/CIRCULATIONAHA.106.667741
   Arteaga RB, 2006, AM J CARDIOL, V98, P70, DOI 10.1016/j.amjcard.2006.01.054
   Ay C, 2007, HAEMATOLOGICA, V92, P374, DOI 10.3324/haematol.10828
   BARON AD, 1994, AM J PHYSIOL, V266, pE248, DOI 10.1152/ajpendo.1994.266.2.E248
   Baron AD, 2000, DIABETES, V49, P768, DOI 10.2337/diabetes.49.5.768
   Basili S, 2006, J AM COLL CARDIOL, V48, P2531, DOI 10.1016/j.jacc.2006.08.040
   Bastelica D, 2002, ARTERIOSCL THROM VAS, V22, P173, DOI 10.1161/hq0102.101552
   Beltowski J, 2006, ATHEROSCLEROSIS, V189, P47, DOI 10.1016/j.atherosclerosis.2006.03.003
   Canavan B, 2005, J CLIN ENDOCR METAB, V90, P5779, DOI 10.1210/jc.2005-0780
   Carter AM, 2007, ARTERIOSCL THROM VAS, V27, P2783, DOI 10.1161/ATVBAHA.107.153221
   Cigolini M, 1996, THROMB HAEMOSTASIS, V76, P69
   Coggins M, 2001, DIABETES, V50, P2682, DOI 10.2337/diabetes.50.12.2682
   Collet JP, 2006, ARTERIOSCL THROM VAS, V26, P2567, DOI 10.1161/01.ATV.0000241589.52950.4c
   Corsonello A, 2003, INT J OBESITY, V27, P566, DOI 10.1038/sj.ijo.0802273
   Crandall DL, 2006, ARTERIOSCL THROM VAS, V26, P2209, DOI 10.1161/01.ATV.0000235605.51400.9d
   Danesh J, 2005, JAMA-J AM MED ASSOC, V294, P1799, DOI 10.1001/jama.294.14.1799
   Davì G, 2002, JAMA-J AM MED ASSOC, V288, P2008, DOI 10.1001/jama.288.16.2008
   De Taeye BM, 2006, J BIOL CHEM, V281, P32796, DOI 10.1074/jbc.M606214200
   Deguchi H, 2005, CIRCULATION, V112, P893, DOI 10.1161/CIRCULATIONAHA.104.521344
   DESOUSA JC, 1989, HAEMOSTASIS, V19, P125
   Diamant M, 2002, CIRCULATION, V106, P2442, DOI 10.1161/01.CIR.0000036596.59665.C6
   Doggen CJM, 2004, ARTERIOSCL THROM VAS, V24, P1970, DOI 10.1161/01.ATV.0000143134.87051.46
   Elbatarny HS, 2007, EUR J PHARMACOL, V558, P7, DOI 10.1016/j.ejphar.2006.11.052
   Englyst NA, 2003, DIABETES, V52, P1248, DOI 10.2337/diabetes.52.5.1248
   Eren M, 2002, CIRCULATION, V106, P491, DOI 10.1161/01.CIR.0000023186.60090.FB
   Fain JN, 2004, ENDOCRINOLOGY, V145, P2273, DOI 10.1210/en.2003-1336
   Ferreira IA, 2006, ARTERIOSCL THROM VAS, V26, P417, DOI 10.1161/01.ATV.0000199519.37089.a0
   Festa A, 2002, DIABETES, V51, P1131, DOI 10.2337/diabetes.51.4.1131
   Festa A, 2006, CIRCULATION, V113, P1753, DOI 10.1161/CIRCULATIONAHA.106.616177
   Folsom A R, 1992, Ann Epidemiol, V2, P481
   Freeman MS, 2003, THROMB HAEMOSTASIS, V89, P161
   Giandomenico G, 2005, J THROMB HAEMOST, V3, P1042, DOI 10.1111/j.1538-7836.2005.01327.x
   Godsland IF, 2005, J CLIN ENDOCR METAB, V90, P190, DOI 10.1210/jc.2004-1292
   González-Ordóñez AJ, 2003, HAEMATOLOGICA, V88, P1035
   Grant PJ, 2007, J INTERN MED, V262, P157, DOI 10.1111/j.1365-2796.2007.01824.x
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Gualillo O, 2007, TRENDS CARDIOVAS MED, V17, P275, DOI 10.1016/j.tcm.2007.09.005
   Haffner SM, 1997, INT J OBESITY, V21, P393, DOI 10.1038/sj.ijo.0800419
   Hansson PO, 1999, ARCH INTERN MED, V159, P1886, DOI 10.1001/archinte.159.16.1886
   Hu G, 2004, ARCH INTERN MED, V164, P1066, DOI 10.1001/archinte.164.10.1066
   Ingelsson E, 2007, CIRCULATION, V116, P984, DOI 10.1161/CIRCULATIONAHA.107.708537
   Jiménez MV, 2007, EUR J ENDOCRINOL, V156, P497, DOI 10.1530/EJE-06-0662
   JuhanVague I, 1996, CIRCULATION, V94, P2057, DOI 10.1161/01.CIR.94.9.2057
   JUHANVAGUE I, 1993, ARTERIOSCLER THROMB, V13, P1865, DOI 10.1161/01.ATV.13.12.1865
   Kanaya AM, 2006, ARCH INTERN MED, V166, P350, DOI 10.1001/archinte.166.3.350
   Kato H, 2006, ARTERIOSCL THROM VAS, V26, P224, DOI 10.1161/01.ATV.0000194076.84568.81
   Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213
   Konstantinides S, 2001, J CLIN INVEST, V108, P1533, DOI 10.1172/JCI13143
   Konstantinides S, 2001, ANN NY ACAD SCI, V947, P134
   Korporaal SJA, 2006, PATHOPHYSIOL HAEMO T, V35, P270, DOI 10.1159/000093220
   Kraja AT, 2007, NUTR METAB, V4, DOI 10.1186/1743-7075-4-28
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lebrun P, 2000, J BIOL CHEM, V275, P38371, DOI 10.1074/jbc.M006162200
   Liang XB, 2006, AM J PHYSIOL-ENDOC M, V290, pE103, DOI 10.1152/ajpendo.00605.2004
   Lijnen HR, 2006, THROMB HAEMOSTASIS, V96, P731, DOI 10.1160/TH06-08-0422
   Lijnen HR, 2005, J THROMB HAEMOST, V3, P1174, DOI 10.1111/j.1538-7836.2005.01390.x
   Lijnen HR, 2003, ARTERIOSCL THROM VAS, V23, P78, DOI 10.1161/01.ATV.0000044457.60665.DD
   López-Alemany R, 2003, EUR J BIOCHEM, V270, P814, DOI 10.1046/j.1432-1033.2003.03453.x
   Lteif A, 2007, DIABETES, V56, P728, DOI 10.2337/db06-1406
   Ma LJ, 2004, DIABETES, V53, P336, DOI 10.2337/diabetes.53.2.336
   Malone PC, 2006, QJM-INT J MED, V99, P581, DOI 10.1093/qjmed/hcl070
   Meerarani P, 2007, INDIAN J EXP BIOL, V45, P103
   Meigs JB, 2000, JAMA-J AM MED ASSOC, V283, P221, DOI 10.1001/jama.283.2.221
   Meigs JB, 2006, DIABETES, V55, P530, DOI 10.2337/diabetes.55.02.06.db05-1041
   Meigs JB, 2003, DIABETES, V52, P2160, DOI 10.2337/diabetes.52.8.2160
   Mertens I, 2006, INT J OBESITY, V30, P1308, DOI 10.1038/sj.ijo.0803189
   Mineo C, 2006, CIRC RES, V98, P1352, DOI 10.1161/01.RES.0000225982.01988.93
   Montagnani M, 2002, J BIOL CHEM, V277, P1794, DOI 10.1074/jbc.M103728200
   Morange PE, 1999, ARTERIOSCL THROM VAS, V19, P1361, DOI 10.1161/01.ATV.19.5.1361
   Nakata M, 1999, DIABETES, V48, P426, DOI 10.2337/diabetes.48.2.426
   Napoleone E, 2007, J THROMB HAEMOST, V5, P1462, DOI 10.1111/j.1538-7836.2007.02578.x
   Nicolucci A, 2007, EUR HEART J, V28, P1925, DOI 10.1093/eurheartj/ehm248
   Ozata M, 2001, OBES RES, V9, P627, DOI 10.1038/oby.2001.82
   Picchi A, 2006, CIRC RES, V99, P69, DOI 10.1161/01.RES.0000229685.37402.80
   Prandoni P, 2007, J INTERN MED, V262, P341, DOI 10.1111/j.1365-2796.2007.01815.x
   Ray JG, 2007, QJM-INT J MED, V100, P679, DOI 10.1093/qjmed/hcm083
   Sakkinen PA, 2000, AM J EPIDEMIOL, V152, P897, DOI 10.1093/aje/152.10.897
   Samad F, 1998, P NATL ACAD SCI USA, V95, P7591, DOI 10.1073/pnas.95.13.7591
   Samad F, 2001, BLOOD, V98, P3353, DOI 10.1182/blood.V98.12.3353
   Schäfer K, 2001, FASEB J, V15, P1840, DOI 10.1096/fj.00-0750fje
   Schalkwijk CG, 2006, THROMB HAEMOSTASIS, V96, P698, DOI 10.1160/06-11-0631
   Scroyen I, 2007, J THROMB HAEMOST, V5, P139, DOI 10.1111/j.1538-7836.2006.02284.x
   Shimomura I, 1996, NAT MED, V2, P800, DOI 10.1038/nm0796-800
   Sobel BE, 1999, CIRCULATION, V99, P2496, DOI 10.1161/01.CIR.99.19.2496
   Tamminen M, 2003, INT J OBESITY, V27, P907, DOI 10.1038/sj.ijo.0802312
   Trovati M, 2002, J DIABETES COMPLICAT, V16, P35, DOI 10.1016/S1056-8727(01)00196-9
   Trovati M, 1998, DIABETOLOGIA, V41, P609, DOI 10.1007/s001250050958
   Vaidyula VR, 2006, DIABETES, V55, P202, DOI 10.2337/diabetes.55.1.202
   Vayá A, 2002, BRIT J HAEMATOL, V118, P255, DOI 10.1046/j.1365-2141.2002.03563.x
   von Hundelshausen P, 2007, CIRC RES, V100, P27, DOI 10.1161/01.RES.0000252802.25497.b7
   Westerbacka J, 2002, ARTERIOSCL THROM VAS, V22, P167, DOI 10.1161/hq0102.101546
   Yudkin JS, 2000, ATHEROSCLEROSIS, V148, P209, DOI 10.1016/S0021-9150(99)00463-3
   Ziccardi P, 2002, CIRCULATION, V105, P804, DOI 10.1161/hc0702.104279
NR 102
TC 147
Z9 160
U1 1
U2 7
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0340-6245
EI 2567-689X
J9 THROMB HAEMOSTASIS
JI Thromb. Haemost.
PD JUN
PY 2008
VL 99
IS 6
BP 995
EP 1000
DI 10.1160/TH07-11-0682
PG 6
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 314SU
UT WOS:000256829900006
PM 18521499
DA 2025-06-11
ER

PT J
AU Gao, CH
   Gong, NY
   Chen, FT
   Hu, SR
   Zhou, QX
   Gao, X
AF Gao, Chunhao
   Gong, Nengyun
   Chen, Fangtian
   Hu, Shiran
   Zhou, Qingxin
   Gao, Xiang
TI The Effects of Astaxanthin on Metabolic Syndrome: A Comprehensive Review
SO MARINE DRUGS
LA English
DT Review
DE astaxanthin; metabolic syndrome; obesity; insulin resistance;
   dyslipidemia
ID DIET-INDUCED OBESITY; IMPROVES GLUCOSE-METABOLISM; REDUCES
   BLOOD-PRESSURE; RECEPTOR PPAR-ALPHA; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; LIPID-METABOLISM; SKELETAL-MUSCLE; ADIPOSE-TISSUE; MICE
AB Metabolic syndrome (MS) represents a complex cluster of metabolic disorders primarily characterized by obesity, insulin resistance, hyperglycemia, dyslipidemia, hypertension, and hyperuricemia. Diet and functional ingredients play a pivotal role in seeking non-pharmacological strategies to prevent and ameliorate MS. Astaxanthin (AST), a carotenoid found in various marine organisms, exhibits exceptional antioxidant properties and holds great promise as a natural compound that improves MS. This article introduces the basic properties of AST, including its absorptance and metabolic pathways, along with various isomers. Most importantly, we comprehensively review the effects and mechanisms of AST on improving the primary components of MS. These mechanisms primarily involve regulating signal transduction, transport, or metabolic pathways within the body, as well as influencing intestinal microbiota and metabolites, thereby exerting positive effects on metabolism and inhibiting the occurrence of MS. This review emphasizes the potential efficacy of AST in managing MS. However, more studies are needed to confirm the clinical effect of AST on MS and reveal potential molecular mechanisms.
C1 [Gao, Chunhao; Gong, Nengyun; Hu, Shiran; Gao, Xiang] Qingdao Univ, Coll Life Sci, Qingdao 266071, Peoples R China.
   [Chen, Fangtian; Zhou, Qingxin] Rizhao Polytech, Shandong Engn Res Ctr Efficient Utilizat Technol M, Shandong Engn & Technol Res Ctr Marine Crustacean, Rizhao Key Lab Efficient Utilizat Marine Food Reso, Rizhao 276826, Peoples R China.
C3 Qingdao University; Rizhao Polytechnic
RP Gao, X (corresponding author), Qingdao Univ, Coll Life Sci, Qingdao 266071, Peoples R China.; Zhou, QX (corresponding author), Rizhao Polytech, Shandong Engn Res Ctr Efficient Utilizat Technol M, Shandong Engn & Technol Res Ctr Marine Crustacean, Rizhao Key Lab Efficient Utilizat Marine Food Reso, Rizhao 276826, Peoples R China.
EM gaoch0306@163.com; gny907@126.com; fangxitianjian@126.com;
   hushiran0131@163.com; sdzhouqingxin@126.com; gaoxiang@qdu.edu.cn
RI Gao, Xiang/AAM-6922-2021
OI Gao, Xiang/0000-0002-4674-0317
FU Natural Science Foundation of Shandong Province; Shandong Province
   Colleges and Universities "youth innovation technology plan" project
   [2019KJF014];  [ZR2024MC094]
FX This research was funded by the Natural Science Foundation of Shandong
   Province (ZR2024MC094) and the Shandong Province Colleges and
   Universities "youth innovation technology plan" project (2019KJF014).
CR Abbasian F, 2023, HELIYON, V9, DOI 10.1016/j.heliyon.2023.e19399
   Abenavoli L, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112690
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Ambroselli D, 2023, NUTRIENTS, V15, DOI 10.3390/nu15030640
   Amouzegar A, 2023, J TRANSL MED, V21, DOI 10.1186/s12967-023-04639-w
   Aoi W, 2008, BIOCHEM BIOPH RES CO, V366, P892, DOI 10.1016/j.bbrc.2007.12.019
   Arunkumar E, 2012, FOOD FUNCT, V3, P120, DOI 10.1039/c1fo10161g
   Baralic I, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/783761
   Bárcena C, 2019, NAT MED, V25, P1234, DOI 10.1038/s41591-019-0504-5
   BECKER RC, 1993, CLEV CLIN J MED, V60, P353, DOI 10.3949/ccjm.60.5.353
   Belete R, 2021, DIABETOL METAB SYNDR, V13, DOI 10.1186/s13098-021-00641-8
   Bhuvaneswari S, 2012, CAN J PHYSIOL PHARM, V90, P1544, DOI 10.1139/y2012-119
   Bhuvaneswari S, 2010, PROCESS BIOCHEM, V45, P1406, DOI 10.1016/j.procbio.2010.05.016
   Brendler T, 2019, PHYTOTHER RES, V33, P3090, DOI 10.1002/ptr.6514
   Brown EM, 2023, CELL HOST MICROBE, V31, P173, DOI 10.1016/j.chom.2023.01.009
   Canas JA, 2017, J CLIN ENDOCR METAB, V102, P1983, DOI 10.1210/jc.2017-00185
   Chen JT, 2017, J MED FOOD, V20, P724, DOI 10.1089/jmf.2016.3819
   Chen YY, 2020, N-S ARCH PHARMACOL, V393, P2517, DOI 10.1007/s00210-020-01861-x
   Chen Y, 2024, NUTRIENTS, V16, DOI 10.3390/nu16010033
   Chen YQ, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/4629189
   Chimonas T, 2010, METAB SYNDR RELAT D, V8, P523, DOI 10.1089/met.2010.0023
   Choi HD, 2011, PHYTOTHER RES, V25, P1813, DOI 10.1002/ptr.3494
   Choi HD, 2011, BRIT J NUTR, V105, P220, DOI 10.1017/S0007114510003454
   Ciaraldi TP, 2023, DIABETES OBES METAB, V25, P1985, DOI 10.1111/dom.15070
   Collins B, 2016, J NUTR BIOCHEM, V31, P150, DOI 10.1016/j.jnutbio.2015.12.021
   Coombes JS, 2016, AM J CLIN NUTR, V103, P283, DOI 10.3945/ajcn.115.115477
   da Silva AA, 2020, CAN J CARDIOL, V36, P671, DOI 10.1016/j.cjca.2020.02.066
   Dang YM, 2024, ANTIOXIDANTS-BASEL, V13, DOI 10.3390/antiox13070879
   Davinelli S, 2018, NUTRIENTS, V10, DOI 10.3390/nu10040522
   Dayi Taygun, 2022, J Prev Med Hyg, V63, pE56, DOI 10.15167/2421-4248/jpmh2022.63.2S3.2747
   Donhowe EG, 2014, FOOD BIOPROCESS TECH, V7, P338, DOI 10.1007/s11947-013-1244-z
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Fen ZG, 2021, ENDOCR J, V68, P451, DOI 10.1507/endocrj.EJ20-0699
   Gao HL, 2021, CARDIOVASC TOXICOL, V21, P1045, DOI 10.1007/s12012-021-09695-6
   Gao HL, 2021, J CARDIOVASC PHARM, V77, P170, DOI 10.1097/FJC.0000000000000953
   Gao Y, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21062149
   Gastaldelli A, 2017, DIABETES, V66, P815, DOI 10.2337/db16-1167
   Gowd V, 2021, MOL NUTR FOOD RES, V65, DOI 10.1002/mnfr.202100252
   Guo ZX, 2024, CRIT REV FOOD SCI, V64, P1791, DOI 10.1080/10408398.2022.2119204
   Habu Y, 2003, BIOCHEM PHARMACOL, V66, P1107, DOI 10.1016/S0006-2952(03)00466-0
   Haswell C, 2021, METABOLITES, V11, DOI 10.3390/metabo11060338
   Heidari M, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1104169
   Heinonen S, 2020, OBES REV, V21, DOI 10.1111/obr.12958
   Herzig S, 2018, NAT REV MOL CELL BIO, V19, P121, DOI 10.1038/nrm.2017.95
   Hess PL, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.117.006103
   Honda M, 2021, J AGR FOOD CHEM, V69, P3489, DOI 10.1021/acs.jafc.1c00087
   Huang J, 2023, J SCI FOOD AGR, V103, P1421, DOI 10.1002/jsfa.12237
   Huang XJ, 2018, INT J BIOL SCI, V14, P1483, DOI 10.7150/ijbs.27173
   Hussein G, 2006, BIOL PHARM BULL, V29, P684, DOI 10.1248/bpb.29.684
   Hussein G, 2005, BIOL PHARM BULL, V28, P47, DOI 10.1248/bpb.28.47
   Hussein G, 2007, LIFE SCI, V80, P522, DOI 10.1016/j.lfs.2006.09.041
   Iafusco D, 2023, CHILDREN-BASEL, V10, DOI 10.3390/children10030516
   Ikeuchi M, 2007, BIOSCI BIOTECH BIOCH, V71, P893, DOI 10.1271/bbb.60521
   Inanir M, 2020, AGING MALE, V23, P1165, DOI 10.1080/13685538.2020.1713742
   Jabarpour M, 2024, PHYTOTHER RES, V38, P321, DOI 10.1002/ptr.8037
   Jäger S, 2007, P NATL ACAD SCI USA, V104, P12017, DOI 10.1073/pnas.0705070104
   Jeon SM, 2016, EXP MOL MED, V48, DOI 10.1038/emm.2016.81
   Jia Y, 2016, J NUTR BIOCHEM, V28, P9, DOI [10.20463/jenb.2016.0055, 10.1016/j.jnutbio.2015.09.015]
   Jones JR, 2005, P NATL ACAD SCI USA, V102, P6207, DOI 10.1073/pnas.0306743102
   Kato T, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061896
   Kim B, 2017, J NUTR BIOCHEM, V43, P27, DOI 10.1016/j.jnutbio.2016.01.006
   Kim B, 2022, BIORESOURCE TECHNOL, V343, DOI 10.1016/j.biortech.2021.126124
   Kim IY, 2019, J CLIN MED, V8, DOI 10.3390/jcm8060837
   Kjobsted R, 2018, FASEB J, V32, P1741, DOI 10.1096/fj.201700442R
   Klinkenberg LJJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0079280
   Kobori M, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18030593
   Landi F, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/1970878
   Landsberg L, 2005, DIABETOLOGIA, V48, P1244, DOI 10.1007/s00125-005-1818-z
   Le YZ, 2020, MAR DRUGS, V18, DOI 10.3390/md18120610
   Lemieux I, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113501
   Leung LYL, 2022, NUTRIENTS, V14, DOI 10.3390/nu14102050
   Li Y, 2021, J OCEAN U CHINA, V20, P973, DOI 10.1007/s11802-021-4724-1
   Li YH, 2022, J AGR FOOD CHEM, V70, P10620, DOI 10.1021/acs.jafc.2c04476
   Liao ZH, 2024, CELL BIOSCI, V14, DOI 10.1186/s13578-024-01304-7
   Liu CJ, 2019, J CLIN MED, V8, DOI 10.3390/jcm8101536
   Liu CZ, 2019, J AGR FOOD CHEM, V67, P5113, DOI 10.1021/acs.jafc.8b06963
   Liu SZ, 2018, J CACHEXIA SARCOPENI, V9, P826, DOI 10.1002/jcsm.12318
   Liu XJ, 2023, J AGR FOOD CHEM, V71, P19920, DOI 10.1021/acs.jafc.3c06863
   Liu XJ, 2023, FOOD CHEM, V404, DOI 10.1016/j.foodchem.2022.134605
   Luc K, 2019, J PHYSIOL PHARMACOL, V70, P809, DOI 10.26402/jpp.2019.6.01
   Luo LX, 2022, LIFE SCI, V311, DOI 10.1016/j.lfs.2022.121091
   Maki KC, 2015, PROSTAG LEUKOTR ESS, V99, P41, DOI 10.1016/j.plefa.2015.05.002
   Martín JF, 2008, MICROB CELL FACT, V7, DOI 10.1186/1475-2859-7-3
   Mashhadi NS, 2018, ASIA PAC J CLIN NUTR, V27, P341, DOI 10.6133/apjcn.052017.11
   Matsuo H, 2009, SCI TRANSL MED, V1, DOI 10.1126/scitranslmed.3000237
   Mazzucotelli A, 2007, DIABETES, V56, P2467, DOI 10.2337/db06-1465
   Mohamed S.M., 2023, Food Chem Adv, V3, DOI 10.1016/j.focha.2023.100335
   Monroy-Ruiz J, 2011, PHARMACOL RES, V63, P44, DOI 10.1016/j.phrs.2010.09.003
   Newsholme P, 2016, BIOCHEM J, V473, P4527, DOI 10.1042/BCJ20160503C
   Ng HY, 2018, KIDNEY BLOOD PRESS R, V43, P1822, DOI 10.1159/000495814
   Nguyen-Le D, 2023, J MICROB BIOTEC FOOD, V12, DOI 10.55251/jmbfs.5950
   Ni YH, 2015, SCI REP-UK, V5, DOI 10.1038/srep17192
   Nishida Y, 2022, NUTRIENTS, V14, DOI 10.3390/nu14010107
   Nishida Y, 2020, J CACHEXIA SARCOPENI, V11, P241, DOI 10.1002/jcsm.12530
   Odeberg JM, 2003, EUR J PHARM SCI, V19, P299, DOI 10.1016/S0928-0987(03)00135-0
   Ortega-Regules AE, 2024, PLANTS-BASEL, V13, DOI 10.3390/plants13121584
   Osterlie M, 2000, J NUTR BIOCHEM, V11, P482, DOI 10.1016/S0955-2863(00)00104-2
   Peng YJ, 2020, FASEB J, V34, P11215, DOI 10.1096/fj.202000558RR
   Pratap K, 2022, FOODS, V11, DOI 10.3390/foods11040565
   Preuss HG, 2011, INT J MED SCI, V8, P126, DOI 10.7150/ijms.8.126
   Radice RP, 2021, FREE RADICAL BIO MED, V171, P156, DOI 10.1016/j.freeradbiomed.2021.05.008
   Ranade AV, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-38506-x
   Rao AR, 2013, J AGR FOOD CHEM, V61, P3842, DOI 10.1021/jf304609j
   Rao RN, 2005, J CHROMATOGR A, V1076, P189, DOI 10.1016/j.chroma.2005.03.133
   Raza SHA, 2021, RES VET SCI, V138, P69, DOI 10.1016/j.rvsc.2021.05.023
   Rodriguez-Ruiz V, 2018, MOLECULES, V23, DOI 10.3390/molecules23102601
   Rong L, 2023, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.1087260
   Saeidi A, 2023, NUTRIENTS, V15, DOI 10.3390/nu15020286
   Saini RK, 2015, FOOD RES INT, V76, P735, DOI 10.1016/j.foodres.2015.07.047
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sasaki Y, 2011, NUTR RES, V31, P784, DOI 10.1016/j.nutres.2011.09.010
   Sayuti NH, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12081552
   Schattenberg JRM, 2005, J BIOL CHEM, V280, P9887, DOI 10.1074/jbc.M410310200
   Shatoor AS, 2022, J PHYSIOL BIOCHEM, V78, P151, DOI 10.1007/s13105-021-00850-9
   Snell TW, 2022, NUTRIENTS, V14, DOI 10.3390/nu14071522
   So A, 2010, J CLIN INVEST, V120, P1791, DOI 10.1172/JCI42344
   Song QQ, 2021, FOOD RES INT, V140, DOI 10.1016/j.foodres.2020.109858
   Su F, 2018, ELECTRON J BIOTECHN, V34, P37, DOI 10.1016/j.ejbt.2018.05.002
   Sugawara T, 2001, J NUTR, V131, P2921, DOI 10.1093/jn/131.11.2921
   Sy C, 2012, MOL NUTR FOOD RES, V56, P1385, DOI 10.1002/mnfr.201200041
   Tachaprutinun A, 2009, INT J PHARMACEUT, V374, P119, DOI 10.1016/j.ijpharm.2009.03.001
   Taghiyar S, 2023, EXCLI J, V22, P502, DOI 10.17179/excli2023-6132
   Tahapary Dicky Levenus, 2022, Diabetes Metab Syndr, V16, P102581, DOI 10.1016/j.dsx.2022.102581
   Takiue Y, 2011, NUCLEOS NUCLEOT NUCL, V30, P113, DOI 10.1080/15257770.2010.551645
   Tanase DM, 2020, J DIABETES RES, V2020, DOI 10.1155/2020/3920196
   Uchiyama K, 2002, REDOX REP, V7, P290, DOI 10.1179/135100002125000811
   Urakaze M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124381
   Wang M, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.840648
   Wang M, 2021, FOOD FUNCT, V12, P9719, DOI [10.1039/D1FO01495A, 10.1039/d1fo01495a]
   Wang WL, 2021, FRONT MICROBIOL, V12, DOI 10.3389/fmicb.2021.762689
   Wang XX, 2023, J SCI FOOD AGR, V103, P2378, DOI 10.1002/jsfa.12429
   Wang X, 2020, DRUG DES DEV THER, V14, P2221, DOI 10.2147/DDDT.S247091
   World Obesity Federation, 2024, World Obesity Atlas
   Wu LW, 2020, BRIT J PHARMACOL, V177, P3760, DOI 10.1111/bph.15099
   Xia W, 2020, PHARMACOL RES, V161, DOI 10.1016/j.phrs.2020.105113
   Xu JQ, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030271
   Xu Y, 2024, FOOD CHEM, V457, DOI 10.1016/j.foodchem.2024.140105
   Xuan RR, 2016, MOL MED REP, V14, P2697, DOI 10.3892/mmr.2016.5569
   Yang CJ, 2022, BMC GERIATR, V22, DOI 10.1186/s12877-022-03672-6
   Yang C, 2017, J AGR FOOD CHEM, V65, P10223, DOI 10.1021/acs.jafc.7b04254
   Yang L, 2021, FOOD CHEM, V343, DOI 10.1016/j.foodchem.2020.128497
   Yang L, 2021, J SCI FOOD AGR, V101, P2576, DOI 10.1002/jsfa.10887
   Yang Y, 2014, BRIT J NUTR, V112, P1797, DOI 10.1017/S0007114514002554
   Yano H, 2014, CLIN EXP NEPHROL, V18, P50, DOI 10.1007/s10157-013-0806-8
   You LJ, 2020, INT J FOOD SCI TECH, V55, P1199, DOI 10.1111/ijfs.14408
   Yu TZ, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12061163
   Yu WJ, 2020, AQUACULTURE, V520, DOI 10.1016/j.aquaculture.2019.734915
   Zhang M, 2020, FOOD FUNCT, V11, P2667, DOI [10.1039/c9fo02907a, 10.1039/C9FO02907A]
   Zhang Y, 2016, BMC CARDIOVASC DISOR, V16, DOI 10.1186/s12872-016-0398-9
   Zhang YL, 2024, J OLEO SCI, V73, P729, DOI 10.5650/jos.ess24003
   Zhao T, 2019, TRENDS FOOD SCI TECH, V91, P354, DOI 10.1016/j.tifs.2019.07.014
   Zheng JY, 2024, FOOD CHEM, V456, DOI 10.1016/j.foodchem.2024.139935
   Zhou QX, 2019, J SCI FOOD AGR, V99, P3662, DOI 10.1002/jsfa.9588
   Zhu L, 2020, J CLIN MED, V9, DOI 10.3390/jcm9123871
   Zhuang JC, 2021, PHARMAZIE, V76, P551, DOI 10.1691/ph.2021.1731
NR 155
TC 1
Z9 1
U1 10
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-3397
J9 MAR DRUGS
JI Mar. Drugs
PD JAN
PY 2025
VL 23
IS 1
AR 9
DI 10.3390/md23010009
PG 24
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA T3X1H
UT WOS:001404367000001
PM 39852511
OA gold
DA 2025-06-11
ER

PT J
AU Hasanpour-Segherlou, Z
   Butler, AA
   Candelario-Jalil, E
   Hoh, BL
AF Hasanpour-Segherlou, Zahra
   Butler, Andrew A.
   Candelario-Jalil, Eduardo
   Hoh, Brian L.
TI Role of the Unique Secreted Peptide Adropin in Various Physiological and
   Disease States
SO BIOMOLECULES
LA English
DT Review
DE adropin; endothelial cells; metabolic syndrome; cardiovascular disease;
   cerebrovascular disorders; subarachnoid hemorrhage
ID DELAYED CEREBRAL VASOSPASM; OBSTRUCTIVE SLEEP-APNEA; FLOW-MEDIATED
   DILATATION; BLOOD-BRAIN-BARRIER; SERUM ADROPIN; NITRIC-OXIDE;
   INSULIN-RESISTANCE; ENDOTHELIAL DYSFUNCTION; DIABETES-MELLITUS;
   OXIDATIVE STRESS
AB Adropin, a secreted peptide hormone identified in 2008, plays a significant role in regulating energy homeostasis, glucose metabolism, and lipid metabolism. Its expression is linked to dietary macronutrient intake and is influenced by metabolic syndrome, obesity, diabetes, and cardiovascular diseases. Emerging evidence suggests that adropin might be a biomarker for various conditions, including metabolic syndrome, coronary artery disease, and hypertensive disorders complicating pregnancy. In cerebrovascular diseases, adropin demonstrates protective effects by reducing blood-brain barrier permeability, brain edema, and infarct size while improving cognitive and sensorimotor functions in ischemic stroke models. The protective effects of adropin extend to preventing endothelial damage, promoting angiogenesis, and mitigating inflammation, making it a promising therapeutic target for cardiovascular and neurodegenerative diseases. This review provides a comprehensive overview of adropin's multifaceted roles in physiological and pathological conditions, as well as our recent work demonstrating adropin's role in subarachnoid hemorrhage-mediated neural injury and delayed cerebral infarction.
C1 [Hasanpour-Segherlou, Zahra; Hoh, Brian L.] Univ Florida, Coll Med, Dept Neurosurg, Gainesville, FL 32610 USA.
   [Butler, Andrew A.] St Louis Univ, Dept Pharmacol & Physiol Sci, St Louis, MO 63104 USA.
   [Candelario-Jalil, Eduardo] Univ Florida, Coll Med, Dept Neurosci, Gainesville, FL 32610 USA.
C3 State University System of Florida; University of Florida; Saint Louis
   University; State University System of Florida; University of Florida
RP Hoh, BL (corresponding author), Univ Florida, Coll Med, Dept Neurosurg, Gainesville, FL 32610 USA.
EM zahra.hasanpoursegherlou@neurosurgery.ufl.edu;
   andrew.butler@health.slu.edu; ecandelario@ufl.edu;
   brian.hoh@neurosurgery.ufl.edu
RI Candelario-Jalil, Eduardo/I-1139-2019
OI Candelario-Jalil, Eduardo/0000-0003-3631-1989
FU NIH [R01NS124620]; Eblen Research Endowment", "Christine Desmond Fund;
   James and Brigette Marino Family Professorship Endowment; St. George
   Family Fund
FX This research was funded by NIH, grant number "R01NS124620", "Eblen
   Research Endowment", "Christine Desmond Fund", "James and Brigette
   Marino Family Professorship Endowment", and "St. George Family Fund".
CR Abbasian S, 2022, HORM-INT J ENDOCRINO, V21, P707, DOI 10.1007/s42000-022-00402-w
   Abulmeaty MMA, 2023, BIOMEDICINES, V11, DOI 10.3390/biomedicines11020440
   Adamczak L, 2023, J PHYSIOL PHARMACOL, V74, P11, DOI 10.26402/jpp.2023.1.02
   Aggarwal G, 2023, NPJ AGING, V9, DOI 10.1038/s41514-023-00122-4
   Aggarwal G, 2024, GEROSCIENCE, V46, P897, DOI 10.1007/s11357-023-00824-3
   Akkaya H, 2022, ARQ BRAS CARDIOL, V119, P402, DOI 10.36660/abc.20210573
   Algul S, 2022, MULT SCLER RELAT DIS, V68, DOI 10.1016/j.msard.2022.104221
   Altamimi TR, 2019, METABOLISM, V98, P37, DOI 10.1016/j.metabol.2019.06.005
   Altincik A, 2015, J PEDIATR ENDOCR MET, V28, P1095, DOI 10.1515/jpem-2015-0051
   Assi MJ, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-43855-8
   Atwoli L, 2021, BMJ LEAD, DOI 10.1136/leader-2021-000548
   Aydin HI, 2016, J PERINAT MED, V44, P669, DOI 10.1515/jpm-2014-0353
   Aydin S, 2013, MOL CELL BIOCHEM, V380, P73, DOI 10.1007/s11010-013-1660-4
   Aydin S, 2013, PEPTIDES, V43, P83, DOI 10.1016/j.peptides.2013.02.014
   Baka S, 2016, J MATERN-FETAL NEO M, V29, P2403, DOI 10.3109/14767058.2015.1089861
   Banerjee S, 2021, NPJ AGING MECH DIS, V7, DOI 10.1038/s41514-021-00076-5
   Baron AD, 2002, J DIABETES COMPLICAT, V16, P92, DOI 10.1016/S1056-8727(01)00209-4
   Beigi A, 2015, GYNECOL ENDOCRINOL, V31, P939, DOI 10.3109/09513590.2015.1081681
   Berezin AA, 2023, BIOMEDICINES, V11, DOI 10.3390/biomedicines11020457
   Berezin AA, 2022, DIAGNOSTICS, V12, DOI 10.3390/diagnostics12122940
   Berezina TA, 2023, J CLIN MED, V12, DOI 10.3390/jcm12062231
   Boric-Skaro D, 2021, LIFE-BASEL, V11, DOI 10.3390/life11040337
   Bousmpoula A, 2018, GYNECOL ENDOCRINOL, V34, P153, DOI 10.1080/09513590.2017.1379498
   Bozic J, 2018, J CLIN SLEEP MED, V14, P1109, DOI 10.5664/jcsm.7204
   Butler AA, 2020, J LIPID RES, V61, P376, DOI 10.1194/jlr.RA119000423
   Butler AA, 2019, J BIOL CHEM, V294, P9706, DOI 10.1074/jbc.RA119.007528
   Butler AA, 2015, SCI REP-UK, V5, DOI 10.1038/srep14691
   Butler AA, 2012, J CLIN ENDOCR METAB, V97, P3783, DOI 10.1210/jc.2012-2194
   Cai ZX, 2021, BIOMARKERS, V26, P517, DOI 10.1080/1354750X.2021.1928754
   Cakmak BD, 2017, J PERINAT MED, V45, P879, DOI 10.1515/jpm-2017-0053
   Celik A, 2013, CARDIOVASC THER, V31, P174, DOI 10.1111/1755-5922.12025
   Celik E, 2013, J PERINAT MED, V41, P375, DOI 10.1515/jpm-2012-0227
   Çelik HT, 2015, CLIN LAB, V61, P1889, DOI 10.7754/Clin.Lab.2015.150420
   Celikhisar H, 2020, CAN RESPIR J, V2020, DOI 10.1155/2020/2571283
   Chang JB, 2018, OBES RES CLIN PRACT, V12, P101, DOI 10.1016/j.orcp.2017.03.001
   Chen RM, 2019, WORLD J PEDIATR, V15, P565, DOI 10.1007/s12519-019-00296-6
   Chen TC, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-96631-x
   Chen X, 2020, FREE RADICAL BIO MED, V160, P191, DOI 10.1016/j.freeradbiomed.2020.08.005
   Chen X, 2020, FASEB J, V34, P10056, DOI 10.1096/fj.202000115RR
   Chen X, 2019, REDOX BIOL, V21, DOI 10.1016/j.redox.2018.101068
   Choe SS, 2016, FRONT ENDOCRINOL, V7, DOI 10.3389/fendo.2016.00030
   Cicek MA, 2023, CURR MED RES OPIN, V39, P1263, DOI 10.1080/03007995.2023.2247317
   Cinkir U, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000027247
   Davoodi M, 2022, EXP PHYSIOL, V107, P813, DOI 10.1113/EP089371
   Demirdogen F, 2022, MULT SCLER RELAT DIS, V66, DOI 10.1016/j.msard.2022.103948
   Dincer E, 2022, FETAL PEDIATR PATHOL, V41, P616, DOI 10.1080/15513815.2021.1945715
   Dodd William S, 2024, Front Stroke, V3, DOI 10.3389/fstro.2024.1371140
   Dodd WS, 2021, BIOCHEM BIOPH RES CO, V582, P105, DOI 10.1016/j.bbrc.2021.10.032
   Dogru YZ, 2023, EPILEPSY RES, V194, DOI 10.1016/j.eplepsyres.2023.107170
   El Gheit REA, 2020, ACS CHEM NEUROSCI, V11, P3077, DOI 10.1021/acschemneuro.0c00424
   Erman H, 2021, J INVEST MED, V69, P1318, DOI 10.1136/jim-2021-001796
   Es-haghi A, 2021, KIDNEY BLOOD PRESS R, DOI 10.1159/000519173
   Fan ZW, 2021, SLEEP BREATH, V25, P117, DOI 10.1007/s11325-020-02072-7
   Faramia J, 2020, CURR OPIN PHARMACOL, V52, P67, DOI 10.1016/j.coph.2020.06.005
   Fujie S, 2017, APPL PHYSIOL NUTR ME, V42, P8, DOI 10.1139/apnm-2016-0310
   Gallo G, 2022, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.798958
   Gao S, 2019, J BIOL CHEM, V294, P13366, DOI 10.1074/jbc.RA119.008967
   Gao S, 2015, MOL METAB, V4, P310, DOI 10.1016/j.molmet.2015.01.005
   Gao S, 2014, DIABETES, V63, P3242, DOI 10.2337/db14-0388
   Ghoshal S, 2021, PEPTIDES, V146, DOI 10.1016/j.peptides.2021.170678
   Ghoshal S, 2018, MOL METAB, V8, P51, DOI 10.1016/j.molmet.2017.12.002
   Glück M, 2019, OBES SURG, V29, P3334, DOI 10.1007/s11695-019-03998-y
   Gozal D, 2013, J PEDIATR-US, V163, P1122, DOI 10.1016/j.jpeds.2013.05.040
   Grzegorzewska AE, 2018, BMC MED GENET, V19, DOI 10.1186/s12881-018-0708-4
   Grzegorzewska AE, 2016, LIFE SCI, V160, P41, DOI 10.1016/j.lfs.2016.07.009
   Gu XS, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000001712
   Gulen B, 2016, AM J EMERG MED, V34, P2061, DOI 10.1016/j.ajem.2016.04.014
   Hänggi D, 2006, ACTA NEUROCHIR, V148, P605, DOI 10.1007/s00701-005-0721-1
   He L, 2021, J OLEO SCI, V70, P657, DOI 10.5650/jos.ess21019
   Herrero L, 2020, OBESITY, V28, P1736, DOI 10.1002/oby.22886
   Hill NR, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0158765
   Hu JL, 2024, CURR CANCER DRUG TAR, V24, P629, DOI 10.2174/0115680096267203231024093601
   Hu WC, 2016, MEDIAT INFLAMM, V2016, DOI 10.1155/2016/6038261
   Inal ZO, 2018, ENDOKRYNOL POL, V69, P135, DOI 10.5603/EP.a2018.0002
   Jasaszwili M, 2021, GENES-BASEL, V12, DOI 10.3390/genes12060914
   Jasaszwili M, 2019, MOL CELL ENDOCRINOL, V496, DOI 10.1016/j.mce.2019.110532
   Jurrissen TJ, 2022, AM J PHYSIOL-HEART C, V323, pH879, DOI 10.1152/ajpheart.00385.2022
   Kadirhan OA, 2022, BIOMEDICA, V42, DOI 10.7705/biomedica.5943
   Kalkan AK, 2018, ARQ BRAS CARDIOL, V111, P39, DOI 10.5935/abc.20180109
   Kaluzna M, 2016, POL ARCH MED WEWN, V126, P474, DOI 10.20452/pamw.3466
   Karaca E, 2024, ANGIOLOGY, V75, P779, DOI 10.1177/00033197231183228
   Karlidag GE, 2020, BIOTECH HISTOCHEM, V95, P152, DOI 10.1080/10520295.2020.1714732
   Kaur R, 2023, DIAGNOSTICS, V13, DOI 10.3390/diagnostics13193158
   Ke YN, 2022, REPROD SCI, V29, P3295, DOI 10.1007/s43032-022-00841-1
   Kheirandish-Gozal L, 2015, INT J OBESITY, V39, P1094, DOI 10.1038/ijo.2015.37
   Kolben Y, 2023, TRANSPL INT, V36, DOI 10.3389/ti.2023.11176
   Kolben Y, 2021, OBES REV, V22, DOI 10.1111/obr.13108
   Kong ZY, 2022, ENT-EAR NOSE THROAT, DOI 10.1177/01455613221074147
   Kuliczkowska-Plaksej J, 2019, ENDOKRYNOL POL, V70, P151, DOI 10.5603/EP.a2018.0092
   Kumar KG, 2008, CELL METAB, V8, P468, DOI 10.1016/j.cmet.2008.10.011
   Kume T, 2016, J ENDOCRINOL INVEST, V39, P747, DOI 10.1007/s40618-016-0453-5
   Kutlu O, 2019, MED PRIN PRACT, V28, P463, DOI 10.1159/000500106
   Li BX, 2020, J DIABETES COMPLICAT, V34, DOI 10.1016/j.jdiacomp.2020.107686
   Li BX, 2020, INT UROL NEPHROL, V52, P2145, DOI 10.1007/s11255-020-02568-x
   Li HY, 2021, CELL DEATH DIS, V12, DOI 10.1038/s41419-021-03610-1
   Li L, 2022, J CARDIOVASC TRANSL, V15, P1256, DOI 10.1007/s12265-022-10248-7
   Li N, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.696163
   Li SP, 2019, ANN CLIN BIOCHEM, V56, P253, DOI 10.1177/0004563218820359
   Lian WL, 2011, INTERNAL MED, V50, P1523, DOI 10.2169/internalmedicine.50.5163
   Liu F, 2021, METAB SYNDR RELAT D, V19, P401, DOI 10.1089/met.2021.0015
   Liu M, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.688586
   Loewen SP, 2017, AM J PHYSIOL-REG I, V312, pR511, DOI 10.1152/ajpregu.00517.2016
   Logan RW, 2019, NAT REV NEUROSCI, V20, P49, DOI 10.1038/s41583-018-0088-y
   Lovren F, 2010, CIRCULATION, V122, pS185, DOI 10.1161/CIRCULATIONAHA.109.931782
   Makboul K.M., 2022, Georgian Med. News, V328329, P115, DOI [10.1093/qjmed/hcad069.397, DOI 10.1093/QJMED/HCAD069.397]
   Mather KJ, 2004, DIABETES, V53, P2060, DOI 10.2337/diabetes.53.8.2060
   Mathers CD, 2006, PLOS MED, V3, DOI 10.1371/journal.pmed.0030442
   Meda C, 2022, NUTRIENTS, V14, DOI 10.3390/nu14163262
   Meda C, 2020, MOL METAB, V32, P97, DOI 10.1016/j.molmet.2019.12.009
   Memi G, 2021, CHINESE J PHYSIOL, V64, P194, DOI 10.4103/cjp.cjp_13_21
   Mierzwicka A, 2016, POSTEP HIG MED DOSW, V70, P881, DOI 10.5604/17322693.1216271
   Muter J, 2018, ENDOCRINOLOGY, V159, P994, DOI 10.1210/en.2017-03064
   Nematbakhsh R, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-48056-x
   Orsso CE, 2019, PEDIATR OBES, V14, DOI 10.1111/ijpo.12493
   Oruc CU, 2017, CLIN CHEM LAB MED, V55, P139, DOI 10.1515/cclm-2016-0329
   Ozkan A, 2022, HIPPOCAMPUS, V32, P253, DOI 10.1002/hipo.23403
   Özkan B, 2019, ANATOL J CARDIOL, V22, P250, DOI 10.14744/AnatolJCardiol.2019.90349
   Palizban AA, 2022, ARCH PHYSIOL BIOCHEM, V128, P378, DOI 10.1080/13813455.2019.1684951
   Peng JP, 2017, PEPTIDES, V97, P1, DOI 10.1016/j.peptides.2017.09.009
   Pluta RM, 2008, ACTA NEUROCHIR SUPPL, V104, P139
   Pluta RM, 2005, PHARMACOL THERAPEUT, V105, P23, DOI 10.1016/j.pharmthera.2004.10.002
   Prystupa A, 2018, ANN AGR ENV MED, V25, P527, DOI 10.26444/aaem/92650
   Qiu X, 2014, PEPTIDES, V52, P19, DOI 10.1016/j.peptides.2013.11.013
   Radic J, 2023, DIAGNOSTICS, V13, DOI 10.3390/diagnostics13172768
   Rezaeinezhad N, 2022, J DIABETES METAB DIS, V21, P583, DOI 10.1007/s40200-022-01020-4
   Rizk FH, 2023, BIOFACTORS, DOI 10.1002/biof.1955
   Samaci H, 2023, J BIOCHEM MOL TOXIC, V37, DOI 10.1002/jbt.23246
   Sato K, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19051293
   Sayin O, 2014, J PEDIATR ENDOCR MET, V27, P479, DOI 10.1515/jpem-2013-0296
   Shimizu H, 2005, NUTR NEUROSCI, V8, P7, DOI 10.1080/10284150500047245
   Shrivastava S, 2023, MED CLIN N AM, V107, P227, DOI 10.1016/j.mcna.2022.10.004
   Siuta M, 2013, NEUROL RES INT, V2013, DOI 10.1155/2013/972417
   Skrzypski M, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23179807
   Skugor A, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0220441
   Smith JA, 2022, ENDOCRINOLOGY, V163, DOI 10.1210/endocr/bqac137
   St-Onge MP, 2014, OBESITY, V22, P1056, DOI 10.1002/oby.20631
   Steinberg HO, 2002, DIABETOLOGIA, V45, P623, DOI 10.1007/s00125-002-0800-2
   Stevens JR, 2016, OBESITY, V24, P1731, DOI 10.1002/oby.21557
   Stokar J, 2022, MOL METAB, V60, DOI 10.1016/j.molmet.2022.101482
   Suhardja A, 2004, NAT CLIN PRACT CARD, V1, P110, DOI 10.1038/ncpcardio0046
   Swarup S., 2024, Metabolic Syndrome
   Thapa D, 2019, PHYSIOL REP, V7, DOI 10.14814/phy2.14043
   Thapa D, 2018, REDOX BIOL, V18, P25, DOI 10.1016/j.redox.2018.06.003
   Topuz M, 2013, J INVEST MED, V61, P1161, DOI 10.2310/JIM.0000000000000003
   Uysal BA, 2022, CLIN EXP HYPERTENS, V44, P223, DOI 10.1080/10641963.2021.2018601
   Vivek K, 2022, GYNECOL ENDOCRINOL, V38, P105, DOI 10.1080/09513590.2021.1963703
   Wang HD, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000019365
   Wang HH, 2017, PREGNANCY HYPERTENS, V8, P6, DOI 10.1016/j.preghy.2017.02.003
   Wang Q, 2022, BMC ENDOCR DISORD, V22, DOI 10.1186/s12902-022-01233-x
   Wang YJ, 2010, J BIOL CHEM, V285, P5013, DOI 10.1074/jbc.M109.080614
   Wei W, 2022, DIABETOL METAB SYNDR, V14, DOI 10.1186/s13098-022-00796-y
   Wong CM, 2014, J BIOL CHEM, V289, P25976, DOI 10.1074/jbc.M114.576058
   Wu CJ, 2016, BIOMED REP, V5, P243, DOI 10.3892/br.2016.693
   Wu LZ, 2014, CLIN CHEM LAB MED, V52, P751, DOI 10.1515/cclm-2013-0844
   Xu W, 2021, PAK J PHARM SCI, V34, P381, DOI 10.36721/PJPS.2021.34.1.SP.381-386.1
   Yang CJ, 2023, STROKE, V54, P234, DOI 10.1161/STROKEAHA.122.039628
   Yang CJ, 2021, REDOX BIOL, V48, DOI 10.1016/j.redox.2021.102197
   Yang CJ, 2018, AGING DIS, V9, P322, DOI 10.14336/AD.2017.0523
   Yang CJ, 2016, PEPTIDES, V81, P29, DOI 10.1016/j.peptides.2016.03.009
   Yang F, 2017, FRONT MOL NEUROSCI, V10, DOI 10.3389/fnmol.2017.00105
   Yang ML, 2021, EUR J PEDIATR, V180, P2253, DOI 10.1007/s00431-021-03977-5
   Yang WQ, 2021, LAB INVEST, V101, P369, DOI 10.1038/s41374-020-00508-y
   Yang Y, 2017, CURR DRUG DELIV, V14, P832, DOI 10.2174/1567201813666161025115531
   Yazgan B, 2021, EXP BIOL MED, V246, P1917, DOI 10.1177/15353702211012417
   Yin CY, 2020, PEDIATR DIABETES, V21, P1132, DOI 10.1111/pedi.13101
   Li YX, 2022, PHARMACEUTICALS-BASE, V15, DOI 10.3390/ph15020173
   Yu HY, 2014, REGUL PEPTIDES, V190, P46, DOI 10.1016/j.regpep.2014.04.001
   Yu LY, 2017, J NEUROCHEM, V143, P750, DOI 10.1111/jnc.14238
   Yu MC, 2022, ACS APPL MATER INTER, V14, P37330, DOI 10.1021/acsami.2c06957
   Yuan X, 2020, J PEDIATR ENDOCR MET, V33, P265, DOI 10.1515/jpem-2019-0329
   Zarrati M, 2019, PROBIOTICS ANTIMICRO, V11, P1202, DOI 10.1007/s12602-018-9470-3
   Zhang Chengjia, 2014, Zhonghua Yi Xue Za Zhi, V94, P1255
   Zhang H, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-18086-3
   Zhang L, 2023, ACTA DIABETOL, V60, P971, DOI 10.1007/s00592-023-02082-3
   Ziarniak K, 2021, ACTA HISTOCHEM, V123, DOI 10.1016/j.acthis.2021.151751
NR 175
TC 1
Z9 1
U1 9
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD DEC
PY 2024
VL 14
IS 12
AR 1613
DI 10.3390/biom14121613
PG 19
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA Q8C8H
UT WOS:001386897200001
PM 39766320
OA gold
DA 2025-06-11
ER

PT J
AU Mutamba, AK
   He, XR
   Wang, T
AF Mutamba, Alpha Kalonda
   He, Xiaori
   Wang, Tao
TI Therapeutic advances in overcoming intrauterine growth restriction
   induced metabolic syndrome
SO FRONTIERS IN PEDIATRICS
LA English
DT Review
DE small gestational age (SGA); lipid metabolism; insulin resistance; type
   2 diabetes; intrauterine growth restriction
ID FOR-GESTATIONAL-AGE; NONALCOHOLIC FATTY LIVER; CATCH-UP GROWTH;
   INSULIN-RESISTANCE; FETAL-GROWTH; LIPID-METABOLISM; DEVELOPMENTAL
   ORIGINS; BIRTH-WEIGHT; FACTOR-I; ENDOCRINE PANCREAS
AB Intrauterine growth restriction (IUGR) remains a great public health challenge as it affects neonatal survival and influences their normal biological development and metabolism. Several clinical researches have revealed the occurrence of metabolic syndrome, such as insulin resistance, obesity, type 2 diabetes mellitus, oxidative stress, dyslipidemia, as direct results of IUGR. Therefore, it is essential to understand its underlying mechanism, impact and develop effective therapies. The purpose of this work is to review the current knowledge on IUGR induced metabolic syndrome and relevant therapies. Here in, we elaborate on the characteristics and causes of IUGR by pointing out recent research findings. Furthermore, we discuss the impact of IUGR on different organs of the body, followed by preclinical studies on IUGR using suitable animal models. Additionally, various metabolic disorders with their genetic implications, such as insulin resistance, type 2 diabetes mellitus, dyslipidemia, obesity are detailed. Finally, the current therapeutic options used in the treatment of IUGR are summarized with some prospective therapies highlighted.
C1 [Mutamba, Alpha Kalonda; He, Xiaori] Cent South Univ, Xiangya Hosp 2, Dept Pediat, Neonatol, Changsha, Peoples R China.
   [Wang, Tao] Cent South Univ, Inst Pediat, Lab Neonatal Dis, Changsha, Peoples R China.
C3 Central South University; Central South University
RP He, XR (corresponding author), Cent South Univ, Xiangya Hosp 2, Dept Pediat, Neonatol, Changsha, Peoples R China.; Wang, T (corresponding author), Cent South Univ, Inst Pediat, Lab Neonatal Dis, Changsha, Peoples R China.
EM hexiaori@csu.edu.cn; wangtao001@csu.edu.cn
FU National Natural Science Foundation of Hunan Province of the People's
   Republic of China [2020JJ4785, 2022JJ30848]; Changsha Municipal Natural
   Science Foundation of Hunan Province of the People's Republic of China
   [AU-YJY-B-LX-20-022]; Ausnutria Food and Nutrition Science Research
   Fund;  [kq2007077]
FX This work was supported by The National Natural Science Foundation of
   Hunan Province of the People's Republic of China (grant no. 2020JJ4785,
   2022JJ30848), Ausnutria Food and Nutrition Science Research Fund
   (AU-YJY-B-LX-20-022), and The Changsha Municipal Natural Science
   Foundation of Hunan Province of the People's Republic of China (grant
   no. kq2007077).
CR Agnihotri B, 2008, INDIAN J PEDIATR, V75, P111, DOI 10.1007/s12098-008-0066-x
   Akpaloo Wisdom, 2014, Malar Res Treat, V2014, P263674, DOI 10.1155/2014/263674
   ANDERSON LL, 1976, J REPROD FERTIL, V46, P363
   [Anonymous], 2020, ULTRASOUND OBST GYN, V56, P298, DOI 10.1002/uog.22134
   [Anonymous], 1995, Bull World Health Organ, V73 Suppl, P1
   BARKER DJP, 1989, LANCET, V2, P577
   Barker DJP, 2004, J EPIDEMIOL COMMUN H, V58, P114, DOI 10.1136/jech.58.2.114
   BARKER DJP, 1986, LANCET, V1, P1077
   BESHYAH SA, 1995, J CLIN ENDOCR METAB, V80, P356, DOI 10.1210/jc.80.2.356
   Black RE, 2013, LANCET, V382, P427, DOI 10.1016/S0140-6736(13)60937-X
   Blondeau B, 2002, DIABETOLOGIA, V45, P394, DOI 10.1007/s00125-001-0767-4
   Briana DD, 2009, EUR J ENDOCRINOL, V160, P337, DOI 10.1530/EJE-08-0621
   Browning JD, 2004, J CLIN INVEST, V114, P147, DOI 10.1172/JCI200422422
   Burke C, 2006, BRAIN RES, V1098, P19, DOI 10.1016/j.brainres.2006.04.129
   Chen K, 2020, APOPTOSIS, V25, P192, DOI 10.1007/s10495-019-01587-z
   Cheng K, 2020, MEAT SCI, V170, DOI 10.1016/j.meatsci.2020.108237
   Cheng K, 2020, BIOMED RES INT, V2020, DOI [10.1155/2020/7043985, 10.1155/2020/7402645]
   Clayton PE, 2007, J CLIN ENDOCR METAB, V92, P804, DOI 10.1210/jc.2006-2017
   Cox P, 2009, BEST PRACT RES CL OB, V23, P751, DOI 10.1016/j.bpobgyn.2009.06.006
   Crume TL, 2014, OBESITY, V22, P608, DOI 10.1002/oby.20565
   Cusi K, 2012, GASTROENTEROLOGY, V142, P711, DOI 10.1053/j.gastro.2012.02.003
   Darendeliler F, 2019, BEST PRACT RES CL EN, V33, DOI 10.1016/j.beem.2019.01.001
   Deodati A, 2020, FRONT GENET, V10, DOI 10.3389/fgene.2019.01270
   Dunger DB, 2006, HORM RES, V65, P34, DOI 10.1159/000091504
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Edelman MJ, 2003, CANCER CHEMOTH PHARM, V51, P439, DOI 10.1007/s00280-003-0580-5
   Ferenc K, 2014, REPROD BIOL, V14, P51, DOI 10.1016/j.repbio.2014.01.005
   Fowden AL, 2005, EARLY HUM DEV, V81, P723, DOI 10.1016/j.earlhumdev.2005.06.007
   Fraser A, 2008, PAEDIATR PERINAT EP, V22, P12, DOI 10.1111/j.1365-3016.2007.00876.x
   Fu Q, 2015, FASEB J, V29, P1176, DOI 10.1096/fj.14-258442
   Gatford KL, 2013, CLIN OBSTET GYNECOL, V56, P520, DOI 10.1097/GRF.0b013e31829e5b29
   GIRARD JR, 1973, J CLIN INVEST, V52, P3190, DOI 10.1172/JCI107519
   Gluckman PD, 2004, TRENDS ENDOCRIN MET, V15, P183, DOI 10.1016/j.tem.2004.03.002
   Gonzalez-Bulnes A, 2016, CURR PHARM BIOTECHNO, V17, P848, DOI 10.2174/1389201017666160519111529
   Groom KM, 2018, AM J OBSTET GYNECOL, V218, pS829, DOI 10.1016/j.ajog.2017.11.565
   Guilbert J J, 2003, Educ Health (Abingdon), V16, P230
   GULER HP, 1987, NEW ENGL J MED, V317, P137, DOI 10.1056/NEJM198707163170303
   Hales CN, 2001, BRIT MED BULL, V60, P5, DOI 10.1093/bmb/60.1.5
   He JT, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0136848
   He QH, 2011, MOL BIOSYST, V7, P2147, DOI 10.1039/c1mb05024a
   Hyatt MA, 2011, REPRODUCTION, V141, P119, DOI 10.1530/REP-10-0325
   Iñiguez G, 2006, J CLIN ENDOCR METAB, V91, P4645, DOI 10.1210/jc.2006-0844
   Iñiguez G, 2011, J CLIN ENDOCR METAB, V96, P187, DOI 10.1210/jc.2010-0244
   Intapad S, 2019, HYPERTENSION, V73, P620, DOI 10.1161/HYPERTENSIONAHA.118.12134
   Jaquet D, 2003, HORM RES, V59, P1, DOI 10.1159/000067940
   Jaquet D, 2001, J CLIN ENDOCR METAB, V86, P3266, DOI 10.1210/jc.86.7.3266
   Jensen CB, 2002, DIABETES, V51, P1271, DOI 10.2337/diabetes.51.4.1271
   Jump DB, 2005, J NUTR, V135, P2503, DOI 10.1093/jn/135.11.2503
   KARLBERG J, 1995, PEDIATR RES, V38, P733, DOI 10.1203/00006450-199511000-00017
   Kelley DE, 2000, DIABETES, V49, P677, DOI 10.2337/diabetes.49.5.677
   Kerns SL, 2014, J CLIN ENDOCR METAB, V99, pE2117, DOI 10.1210/jc.2014-1949
   Kim HJ, 2002, ANN NY ACAD SCI, V967, P34
   Korpysz Alicja, 2019, Pediatr Endocrinol Diabetes Metab, V25, P188, DOI 10.5114/pedm.2019.91547
   Lakshmy R, 2013, REV ENDOCR METAB DIS, V14, P229, DOI 10.1007/s11154-013-9266-4
   Leunissen RWJ, 2009, JAMA-J AM MED ASSOC, V301, P2234, DOI 10.1001/jama.2009.761
   Li W, 2018, ASIAN AUSTRAL J ANIM, V31, P686, DOI 10.5713/ajas.15.0810
   Li W, 2012, ASIAN AUSTRAL J ANIM, V25, P1096, DOI 10.5713/ajas.2012.12058
   Liu C, 2013, J NUTR BIOCHEM, V24, P954, DOI 10.1016/j.jnutbio.2012.06.016
   Liu JB, 2014, ARCH ANIM NUTR, V68, P111, DOI 10.1080/1745039X.2014.897532
   Lu P, 2016, CELL RES, V26, P1169, DOI 10.1038/cr.2016.108
   Malpique R, 2019, INT J OBESITY, V43, P384, DOI 10.1038/s41366-018-0198-7
   Marchesini G, 2003, HEPATOLOGY, V37, P917, DOI 10.1053/jhep.2003.50161
   Martin-Gronert MS, 2007, J INTERN MED, V261, P437, DOI 10.1111/j.1365-2796.2007.01800.x
   Mead JR, 2002, J MOL MED, V80, P753, DOI 10.1007/s00109-002-0384-9
   Melamed N, 2021, INT J GYNECOL OBSTET, V152, P3, DOI 10.1002/ijgo.13522
   Merrifield CA, 2011, MOL BIOSYST, V7, P2577, DOI 10.1039/c1mb05023k
   Metrustry SJ, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194316
   Miller J, 2008, SEMIN PERINATOL, V32, P274, DOI 10.1053/j.semperi.2008.04.010
   Moore GE, 2015, PHILOS T R SOC B, V370, DOI 10.1098/rstb.2014.0074
   Morrison JL, 2008, CLIN EXP PHARMACOL P, V35, P730, DOI 10.1111/j.1440-1681.2008.04975.x
   Musso G, 2009, PROG LIPID RES, V48, P1, DOI 10.1016/j.plipres.2008.08.001
   Newton KP, 2017, J PEDIATR-US, V187, P141, DOI 10.1016/j.jpeds.2017.03.007
   Niu Y, 2019, ANIMALS-BASEL, V9, DOI 10.3390/ani9121098
   Nobili V, 2007, DIABETES CARE, V30, P2638, DOI 10.2337/dc07-0281
   Ozanne SE, 2004, NATURE, V427, P411, DOI 10.1038/427411b
   PHILLIPS DIW, 1994, DIABETOLOGIA, V37, P150, DOI 10.1007/s001250050086
   Pruis MGM, 2014, ACTA PHYSIOL, V210, P296, DOI 10.1111/apha.12171
   RANDLE PJ, 1963, LANCET, V1, P785
   Roberts DJ, 2008, J CLIN PATHOL, V61, P1254, DOI 10.1136/jcp.2008.055236
   Rosenberg A, 2008, SEMIN PERINATOL, V32, P219, DOI 10.1053/j.semperi.2007.11.003
   Saget S, 2020, MOL METAB, V42, DOI 10.1016/j.molmet.2020.101083
   Salam RA, 2014, CURR OPIN CLIN NUTR, V17, P249, DOI 10.1097/MCO.0000000000000051
   Sánchez-Garrido MA, 2013, ENDOCRINOLOGY, V154, P3387, DOI 10.1210/en.2012-2157
   Schröder HJ, 2003, EUR J OBSTET GYN R B, V110, pS29, DOI 10.1016/S0301-2115(03)00170-2
   Shrivastava D, 2020, J OBSTET GYN INDIA, V70, P103, DOI 10.1007/s13224-019-01278-4
   Simmons RA, 2006, FREE RADICAL BIO MED, V40, P917, DOI 10.1016/j.freeradbiomed.2005.12.018
   Skinner AC, 2015, NEW ENGL J MED, V373, P1307, DOI 10.1056/NEJMoa1502821
   Sloboda DM, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006744
   Soto N, 2003, J CLIN ENDOCR METAB, V88, P3645, DOI 10.1210/jc.2002-030031
   Sukrat B, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/769057
   Suliburska J, 2014, EUR J NUTR, V53, P387, DOI 10.1007/s00394-013-0533-7
   Thamotharan M, 2005, AM J PHYSIOL-ENDOC M, V288, pE935, DOI 10.1152/ajpendo.00342.2004
   Vaiserman A, 2019, INT J GENOMICS, V2019, DOI 10.1155/2019/3821409
   VANASSCHE FA, 1977, BRIT J OBSTET GYNAEC, V84, P751, DOI 10.1111/j.1471-0528.1977.tb12486.x
   VERHAEGHE J, 1993, AM J OBSTET GYNECOL, V169, P89, DOI 10.1016/0002-9378(93)90137-8
   Vickers MH, 2000, AM J PHYSIOL-ENDOC M, V279, pE83
   Vuguin P, 2004, DIABETES, V53, P2617, DOI 10.2337/diabetes.53.10.2617
   Wang JJ, 2008, J NUTR, V138, P60, DOI 10.1093/jn/138.1.60
   Wang XL, 2007, J CLIN ENDOCR METAB, V92, P681, DOI 10.1210/jc.2006-1281
   Waterland RA, 2006, HUM MOL GENET, V15, P705, DOI 10.1093/hmg/ddi484
   Wei S, 2010, DOMEST ANIM ENDOCRIN, V39, P231, DOI 10.1016/j.domaniend.2010.06.004
   WIDDOWSON EM, 1971, BIOL NEONATE, V19, P329, DOI 10.1159/000240427
   Yamamoto T, 2007, J BIOL CHEM, V282, P11687, DOI 10.1074/jbc.M611911200
   Zambrano E, 2014, MOL CELL ENDOCRINOL, V382, P538, DOI 10.1016/j.mce.2013.09.008
   Zhang ZL, 2016, FREE RADICAL BIO MED, V101, P272, DOI 10.1016/j.freeradbiomed.2016.10.498
   Zhou J, 2019, FASEB J, V33, P1110, DOI 10.1096/fj.201800172R
NR 106
TC 6
Z9 6
U1 0
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-2360
J9 FRONT PEDIATR
JI Front. Pediatr.
PD JAN 11
PY 2023
VL 10
AR 1040742
DI 10.3389/fped.2022.1040742
PG 9
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 8F8VW
UT WOS:000919935100001
PM 36714657
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Stewart-Knox, BJ
AF Stewart-Knox, BJ
TI Psychological underpinnings of metabolic syndrome
SO PROCEEDINGS OF THE NUTRITION SOCIETY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the
   Nurtition-Society/British-Association-for-Parenteral-and-Enteral-Nutriti
   on
CY NOV 17-18, 2004
CL Telford, ENGLAND
SP Nutr Soc, British Assoc Parenteral & Enteral Nutr
DE metabolic syndrome; psychological; social; demographic; cultural
ID TIME PHYSICAL-ACTIVITY; INSULIN-RESISTANCE; WAIST CIRCUMFERENCE;
   WEIGHT-GAIN; CARDIORESPIRATORY FITNESS; SOCIOECONOMIC-FACTORS; ABDOMINAL
   OBESITY; VISCERAL OBESITY; YOUNG ADULTHOOD; NERVOUS-SYSTEM
AB Metabolic syndrome (MS) is more common among socio-economically disadvantaged individuals and is associated with certain risky lifestyle practices. MS also appears to be triggered by adverse social circumstances and chronic stress. The present paper reviews accumulating evidence to imply that individuals who have certain personality and behaviour traits are particularly predisposed to develop MS, and brings together theories that relate to possible psychological mechanisms underlying MS. It considers how such factors might interact causally to encourage the development of MS. As part of the EU-funded LIPGENE Integrated Project, multi-level modelling will be undertaken to explore potential pathways to MS, taking into consideration the interplay between a range of psycho-social, demographic, cultural and lifestyle factors thought to contribute to the development of MS. Data will be gathered for this purpose from a representative sample of > 50-year-olds living in Britain (n 1000) and Portugal (n 500). It is anticipated that this information will assist in the development and targetting of future intervention to prevent and treat MS in the normal population.
C1 Univ Ulster, No Ireland Ctr Food & Hlth, Coleraine BT52 1SA, Londonderry, North Ireland.
C3 Ulster University
RP Univ Ulster, No Ireland Ctr Food & Hlth, Coleraine BT52 1SA, Londonderry, North Ireland.
EM b.knox@ulster.ac.uk
OI Stewart-Knox, Barbara/0000-0002-6741-3657
CR Alméras N, 2004, J CLIN PSYCHIAT, V65, P557
   Baptista T, 1999, ACTA PSYCHIAT SCAND, V100, P3, DOI 10.1111/j.1600-0447.1999.tb10908.x
   BAREFOOT JC, 1991, HEALTH PSYCHOL, V10, P18, DOI 10.1037/0278-6133.10.1.18
   Basu R, 2004, BIPOLAR DISORD, V6, P314, DOI 10.1111/j.1399-5618.2004.00126.x
   Benetou V, 2004, EUR J EPIDEMIOL, V19, P803, DOI 10.1023/B:EJEP.0000036582.38987.ca
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   Björntorp P, 2000, INT J OBESITY, V24, pS80, DOI 10.1038/sj.ijo.0801285
   Björntorp P, 1999, ANN NY ACAD SCI, V892, P297, DOI 10.1111/j.1749-6632.1999.tb07803.x
   Björntorp P, 1999, DIABETES-METAB RES, V15, P427
   Black PH, 2003, BRAIN BEHAV IMMUN, V17, P350, DOI 10.1016/S0889-1591(03)00048-5
   BRINDLEY DN, 1995, INT J OBESITY, V19, pS69
   Brown ES, 2004, BIOL PSYCHIAT, V55, P1, DOI 10.1016/S0006-3223(03)00473-6
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   Brunner EJ, 1997, DIABETOLOGIA, V40, P1341, DOI 10.1007/s001250050830
   BUTTRISS J, 2003, NUTR B, V28, P381
   CAMRAS L, 1980, AM J PSYCHOL, V93, P751, DOI 10.2307/1422394
   Chen W, 2000, DIABETES, V49, P1042, DOI 10.2337/diabetes.49.6.1042
   Cook WW, 1954, J APPL PSYCHOL, V38, P414, DOI 10.1037/h0060667
   DANESH HB, 1977, AM J PSYCHIAT, V134, P1109
   DIAMOND EL, 1982, PSYCHOL BULL, V92, P410, DOI 10.1037/0033-2909.92.2.410
   Drapeau V, 2003, PANMINERVA MED, V45, P189
   Eikelis N, 2004, AM J PHYSIOL-ENDOC M, V286, pE744, DOI 10.1152/ajpendo.00489.2003
   Esler M, 2001, AM J HYPERTENS, V14, p304S, DOI 10.1016/S0895-7061(01)02236-1
   Feldman PJ, 2003, HEALTH PSYCHOL, V22, P398, DOI 10.1037/0278-6133.22.4.398
   FRIEDMAN M, 1959, JAMA-J AM MED ASSOC, V169, P1286, DOI 10.1001/jama.1959.03000290012005
   Frost A, 2001, EYE, V15, P739, DOI 10.1038/eye.2001.241
   GIGOLINI M, 1995, METABOLISM CLIN EXPT, V44, P35
   Halford JCG, 2001, CURR DRUG TARGETS, V2, P353, DOI 10.2174/1389450013348209
   HAYNES SG, 1978, AM J EPIDEMIOL, V107, P362, DOI 10.1093/oxfordjournals.aje.a112556
   Hidvégi T, 2001, DIABETES CARE, V24, P2013, DOI 10.2337/diacare.24.11.2013-a
   Ho SC, 2001, INT J OBESITY, V25, P1689, DOI 10.1038/sj.ijo.0801784
   Horsten M, 1999, J CARDIOVASC RISK, V6, P391
   Katzmarzyk PT, 2001, J CLIN EPIDEMIOL, V54, P190, DOI 10.1016/S0895-4356(00)00315-2
   Kerényi Z, 2000, DIABETES CARE, V23, P1444, DOI 10.2337/diacare.23.9.1444
   Kiecolt-Glaser JK, 2002, ANNU REV PSYCHOL, V53, P83, DOI 10.1146/annurev.psych.53.100901.135217
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Laaksonen DE, 2003, DIABETES CARE, V26, P2156, DOI 10.2337/diacare.26.7.2156
   Laaksonen DE, 2002, DIABETES CARE, V25, P1612, DOI 10.2337/diacare.25.9.1612
   Landén M, 2004, PSYCHONEUROENDOCRINO, V29, P1037, DOI 10.1016/j.psyneuen.2003.10.006
   Lawlor DA, 2004, DIABETIC MED, V21, P906, DOI 10.1111/j.1464-5491.2004.01245.x
   Lidfeldt J, 2003, DIABETES OBES METAB, V5, P106, DOI 10.1046/j.1463-1326.2003.00250.x
   Martins IS, 2003, REV SAUDE PUBL, V37, P760, DOI 10.1590/S0034-89102003000600011
   McCaffery JM, 2003, PSYCHOSOM MED, V65, P490, DOI 10.1097/01.PSY.0000041545.52924.82
   McElroy SL, 2004, J CLIN PSYCHIAT, V65, P634
   Meigs JB, 1997, DIABETES, V46, P1594, DOI 10.2337/diabetes.46.10.1594
   Muldoon MF, 2004, J CLIN ENDOCR METAB, V89, P266, DOI 10.1210/jc.2003-031295
   Niaura R, 2000, PSYCHOSOM MED, V62, P7, DOI 10.1097/00006842-200001000-00002
   NIAURA R, 2002, HEART DIS WEEKLY
   Nonogaki K, 2000, DIABETOLOGIA, V43, P533, DOI 10.1007/s001250051341
   Okosun IS, 1998, DIABETES CARE, V21, P1836, DOI 10.2337/diacare.21.11.1836
   Okosun IS, 2000, ANN EPIDEMIOL, V10, P263, DOI 10.1016/S1047-2797(00)00045-4
   Onat A, 2004, INT J OBESITY, V28, P1018, DOI 10.1038/sj.ijo.0802695
   Oppert JM, 1997, OBES RES, V5, P410, DOI 10.1002/j.1550-8528.1997.tb00663.x
   PAFFENBARGER RS, 1978, AM J EPIDEMIOL, V108, P161, DOI 10.1093/oxfordjournals.aje.a112608
   Puttonen S, 2003, INT J BEHAV MED, V10, P106, DOI 10.1207/S15327558IJBM1002_02
   Räikkönen K, 1999, METABOLISM, V48, P1146, DOI 10.1016/S0026-0495(99)90129-4
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Räikkönen K, 2003, HEALTH PSYCHOL, V22, P279, DOI 10.1037/0278-6133.22.3.279
   Raikkonen K, 1996, METABOLISM, V45, P1533, DOI 10.1016/S0026-0495(96)90184-5
   Räikkönen K, 1999, INT J OBESITY, V23, P775, DOI 10.1038/sj.ijo.0800917
   Ravaja N, 1996, SOC SCI MED, V43, P51, DOI 10.1016/0277-9536(95)00333-9
   Rennie KL, 2003, INT J EPIDEMIOL, V32, P600, DOI 10.1093/ije/dyg179
   Risérus U, 2004, DIABETES CARE, V27, P2041, DOI 10.2337/diacare.27.8.2041
   Rosmond R, 2000, INT J OBESITY, V24, P416, DOI 10.1038/sj.ijo.0801173
   Roth JL, 2002, NUTR REV, V60, P335
   Roy S, 2003, GENE EXPRESSION, V11, P251, DOI 10.3727/000000003783992289
   Sargent PA, 1997, PSYCHOPHARMACOLOGY, V133, P309, DOI 10.1007/s002130050407
   Seematter G, 2004, CURR OPIN CLIN NUTR, V7, P169, DOI 10.1097/00075197-200403000-00011
   Siani A, 2002, AM J HYPERTENS, V15, P780, DOI 10.1016/S0895-7061(02)02976-X
   Snijder MB, 2004, INT J OBESITY, V28, P402, DOI 10.1038/sj.ijo.0802567
   Spielberger C. D., 1983, Manual for the State-Trait-Anxiety Inventory: STAI (form Y)
   Steptoe A, 2003, PSYCHOSOM MED, V65, P1029, DOI 10.1097/01.PSY.0000097347.57237.2D
   Vanhala MJ, 1999, INT J OBESITY, V23, P656, DOI 10.1038/sj.ijo.0800898
   Vieta E, 2004, EXPERT OPIN PHARMACO, V5, P1613, DOI 10.1517/14656566.5.7.1613
   VITALIANO PP, 2002, HEART DIS WEEKL 0616
   Waldstein SR, 1999, HEALTH PSYCHOL, V18, P221
   Wallerius S, 2003, J ENDOCRINOL INVEST, V26, P616, DOI 10.1007/BF03347017
   Wamala SP, 1999, DIABETES CARE, V22, P1999, DOI 10.2337/diacare.22.12.1999
   Ward AMV, 2004, METABOLISM, V53, P720, DOI 10.1016/j.metabol.2004.01.008
   Weber-Hamann B, 2002, PSYCHOSOM MED, V64, P274, DOI 10.1097/00006842-200203000-00010
   Wellman PJ, 2003, PHARMACOL BIOCHEM BE, V75, P103, DOI 10.1016/S0091-3057(03)00045-5
   WOODALL KL, 1993, J PERS SOC PSYCHOL, V64, P491, DOI 10.1037/0022-3514.64.3.491
   Yarbrough DE, 1998, DIABETES CARE, V21, P1652, DOI 10.2337/diacare.21.10.1652
   Zimmermann U, 2003, J PSYCHIATR RES, V37, P193, DOI 10.1016/S0022-3956(03)00018-9
NR 84
TC 22
Z9 24
U1 1
U2 6
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0029-6651
EI 1475-2719
J9 P NUTR SOC
JI Proc. Nutr. Soc.
PD JUL
PY 2005
VL 64
IS 3
BP 363
EP 369
DI 10.1079/PNS2005444
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics
GA 949VM
UT WOS:000230816200014
PM 16048670
OA Bronze
DA 2025-06-11
ER

PT J
AU Salonen, P
   Arola, H
   Nygård, CH
   Huhtala, H
AF Salonen, P.
   Arola, H.
   Nygard, C. -H.
   Huhtala, H.
TI Associations of health, dietary and job-related factors, and mental
   problems with cardiovascular diseases in aging
SO JOURNAL OF NUTRITION HEALTH & AGING
LA English
DT Article
DE cardiovascular morbidity; hypertension; health factors; dietary factors;
   job-related factors; mental problems; aging employees
ID METABOLIC SYNDROME; NATIONAL-HEALTH; RISK-FACTORS; HYPERTENSION;
   MORTALITY; DEPRESSION; MORBIDITY; HEART
AB Background: While cardiovascular diseases are prevalent in aging population, associations between different factors and cardiovascular diseases are less studied or inconsistency still exists. Aim: To determine which factors measured at baseline predicted overall cardiovascular diseases and hypertension, and which factors were currently associated with these conditions. Methods: Based on a sample of aging and retired food industry employees (N = 100, mean age 62 years) associations of health, dietary and job-related factors and mental problems with overall cardiovascular morbidity and hypertension were assessed with independent samples t-test, X-2 test and binary logistic regression analyses. Data were derived from health examinations and self-completed questionnaires in 1989 and 2000. Results: Added medical findings, related to cardiovascular diseases, appeared as predictor of overall cardiovascular morbidity, while elevated blood pressure together with high systolic and diastolic pressure, dyslipidernia and elevated blood pressure together, added medical findings, and inability to enjoy daily activities predicted hypertension. According to our analyses most significant current associations with overall cardiovascular morbidity were feeling of weakness, dyspnoea, hopelessness about the future, cardiac arrhythmia, chronic mental stress and lower HDL cholesterol, and with hypertension metabolic syndrome, lower HDL cholesterol, hopelessness about the future and muscular fatigue on exertion. Conclusions: Health factors were most important predictors of hypertension during a long-term period, while health factors together with mental problems had significant current associations with overall cardiovascular morbidity including hypertension.
C1 Univ Tampere, Sch Publ Hlth, FIN-33014 Tampere, Finland.
   Occupat Hlth Ctr, Tampere, Finland.
C3 Tampere University
RP Salonen, P (corresponding author), Univ Tampere, Sch Publ Hlth, FIN-33014 Tampere, Finland.
EM pahasa@saunalahti.fi
OI Huhtala, Heini/0000-0003-1372-430X; nygard,
   clas-hakan/0000-0002-6962-7042
CR AROLA H, 1991, TYOTERVEYSLAAKARI, V2, P27
   *CENTR PENS SEC I, 2001, STAT YB PENS FINL
   Chalmers J, 1999, J HYPERTENS, V17, P151
   Chaudhry SI, 2004, JAMA-J AM MED ASSOC, V292, P1074, DOI 10.1001/jama.292.9.1074
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Everson SA, 2000, HYPERTENSION, V35, P561, DOI 10.1161/01.HYP.35.2.561
   Ford ES, 2004, ATHEROSCLEROSIS, V173, P309, DOI 10.1016/j.atherosclerosis.2003.12.022
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   FRILANDER P, 1989, ATMOS
   Guagnano MT, 2001, INT J OBESITY, V25, P1360, DOI 10.1038/sj.ijo.0801722
   Hu F B, 2001, J Nutr Health Aging, V5, P132
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jiang Wei, 2003, Curr Psychiatry Rep, V5, P47, DOI 10.1007/s11920-003-0009-1
   Jonas BS, 1997, ARCH FAM MED, V6, P43, DOI 10.1001/archfami.6.1.43
   Joynt KE, 2003, BIOL PSYCHIAT, V54, P248, DOI 10.1016/S0006-3223(03)00568-7
   KEYS A, 1972, J CHRON DIS, V25, P329, DOI 10.1016/0021-9681(72)90027-6
   Kritchevsky D, 2001, J Nutr Health Aging, V5, P155
   Kromhout D, 2001, J Nutr Health Aging, V5, P144
   Lawlor DA, 2003, J EPIDEMIOL COMMUN H, V57, P134, DOI 10.1136/jech.57.2.134
   Milner KA, 2001, NURS RES, V50, P233, DOI 10.1097/00006199-200107000-00007
   Milner KA, 1999, AM J CARDIOL, V84, P396, DOI 10.1016/S0002-9149(99)00322-7
   *PAB OHJ, 2004, KLIIN KEM KLINN GEN
   Palmiero P, 2002, AM J HYPERTENS, V15, P615, DOI 10.1016/S0895-7061(02)02934-5
   Renaud S, 2001, J Nutr Health Aging, V5, P131
   Salonen P, 2003, OCCUP MED-OXFORD, V53, P65, DOI 10.1093/occmed/kqg012
   SALONEN P, 2001, 33 ANN C NORD ERG SO, P467
   SALONEN P, 2004, TYO JA IHMINEN, V18, P241
   Schillaci G, 2004, J AM COLL CARDIOL, V43, P1817, DOI 10.1016/j.jacc.2003.12.049
   SIMONSICK EM, 1995, PSYCHOSOM MED, V57, P427, DOI 10.1097/00006842-199509000-00003
   Sowers JR, 2001, HYPERTENSION, V37, P1053, DOI 10.1161/01.HYP.37.4.1053
   *STAT FINL, 2002, FINL FIG
   SULANDER T, 2001, ELAKEIKAISEN VAESTON
   Sumanen Markku P T, 2004, Health Qual Life Outcomes, V2, P60, DOI 10.1186/1477-7525-2-60
   *SUOM SIS YHD AS T, DYSL CURR TREATM
   TUOMI K, 1991, SCAND J WORK ENV HEA, V17, P67
   VANHALA M, EBM GUIDELINES
   Yamamoto Akira, 2003, J Atheroscler Thromb, V10, P176
NR 38
TC 1
Z9 2
U1 0
U2 4
PU SPRINGER FRANCE
PI PARIS
PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE
SN 1279-7707
EI 1760-4788
J9 J NUTR HEALTH AGING
JI J. Nutr. Health Aging
PD MAY-JUN
PY 2006
VL 10
IS 3
BP 193
EP 202
PG 10
WC Geriatrics & Gerontology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Nutrition & Dietetics
GA 044TL
UT WOS:000237695200004
PM 16622582
DA 2025-06-11
ER

PT J
AU Al-Okbi, SY
   Hamed, TE
   Elewa, TA
   Ramadan, AA
   Bakry, BA
   El Karamany, MF
AF Al-Okbi, S. Y.
   Hamed, T. E.
   Elewa, T. A.
   Ramadan, A. A.
   Bakry, B. A.
   El Karamany, M. F.
TI Quinoa seed: A source of lipophilic nutraceuticals for the prevention of
   metabolic syndrome in a rat model
SO GRASAS Y ACEITES
LA English
DT Article
DE Fatty acids; Fructose; Lipophilic extracts; Metabolic syndrome; Quinoa
   seed; Tocopherol
ID CHENOPODIUM-QUINOA; FATTY-ACIDS; FISH-OIL; SERUM; WILLD.; PRECIPITATION;
   EXTRACTION; AMARANTH
AB Metabolic syndrome (MS) is a cluster of metabolic changes including hypertriglyceridemia, elevated glucose tolerance and fatty liver. The aim of this research was to study the bioactivity of petroleum ether extracts prepared from quinoa 1 and Hualhuas quinoa in a MS rat model. Fatty acids and alpha-tocopherol were assessed in the extracts. MS was induced by feeding a high fructose -high fat diet (HFFD). Four groups of rats were assigned: the control group, fed a balanced diet; the control group, fed a HFFD diet; and two test groups, fed on a HFFD diet and treated by either quinoa 1 or hualhuas extract. The Glucose tolerance, plasma lipids, oxidative stress biomarkers, liver lipids and histopathology of the liver and heart were assessed. The results showed that extracts from both quinoa varieties had the potential to prevent MS; although quinoa 1 was more effective. In both varieties, the major fatty acid was linoleic. Hualhuas showed a higher percentage of linolenic acid than quinoa 1; while more alpha-tocopherol was present in quinoa1.
C1 [Al-Okbi, S. Y.; Hamed, T. E.; Ramadan, A. A.] Natl Res Ctr, Nutr & Food Sci Dept, El Buhouth St, Dokki, Cairo, Egypt.
   [Elewa, T. A.; Bakry, B. A.; El Karamany, M. F.] Natl Res Ctr, Field Crops Res Dept, El Buhouth St, Dokki, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); National Research Centre (NRC); Egyptian
   Knowledge Bank (EKB); National Research Centre (NRC)
RP Al-Okbi, SY (corresponding author), Natl Res Ctr, Nutr & Food Sci Dept, El Buhouth St, Dokki, Cairo, Egypt.
EM S_Y_alokbi@hotmail.com
RI ; Ramadan Taha, Asmaa/JFK-9971-2023
OI Bakry, Bakry/0000-0002-7695-3401; Ramadan Taha,
   Asmaa/0000-0003-2626-0006; Al-Okbi, Sahar Y./0000-0002-8114-2718
FU National Research Centre;  [11030126]
FX The authors would like to thank the National Research Centre for
   financing this research. The work was completely implemented in the
   National Research Centre (grant No .11030126)
CR James LEA, 2009, ADV FOOD NUTR RES, V58, P1, DOI 10.1016/S1043-4526(09)58001-1
   Al-Okbi SY, 2020, J OLEO SCI, V69, P771, DOI 10.5650/jos.ess20015
   Al-Okbi Sahar Y, 2018, Pak J Biol Sci, V21, P348, DOI 10.3923/pjbs.2018.348.358
   Al-Okbi SY., 2021, J HERBMED PHARM, V10, P319, DOI [10.34172/jhp.2021.37, DOI 10.34172/JHP.2021.37]
   Altuna JL, 2018, Asian J. Pharm. Clin. Res., V11, P209, DOI [10.22159/ajpcr.2018.v11i11.24889, DOI 10.22159/AJPCR.2018.V11I11.24889]
   Bancroft JD., 2018, Bancroft's theory and practice of histological techniques, P126, DOI [10.1016/B978-0-7020-6864-5.00010-4, DOI 10.1016/B978-0-7020-6864-5.00010-4]
   Bibus D, 2015, PROSTAG LEUKOTR ESS, V99, P19, DOI 10.1016/j.plefa.2015.04.005
   Bovolini A, 2021, INT J SPORTS MED, V42, P199, DOI 10.1055/a-1263-0898
   BURSTEIN M, 1970, J LIPID RES, V11, P583
   Cequier-Sánchez E, 2008, J AGR FOOD CHEM, V56, P4297, DOI 10.1021/jf073471e
   el Hafid R., 2005, Technical Report, P18
   Gabrial Shreef G N, 2016, Open Access Maced J Med Sci, V4, P565, DOI 10.3889/oamjms.2016.115
   Indarti E, 2005, J FOOD COMPOS ANAL, V18, P161, DOI 10.1016/j.jfca.2003.12.007
   Koracevic D, 2001, J CLIN PATHOL, V54, P356, DOI 10.1136/jcp.54.5.356
   Koziol M. J., 1993, New crops., P328
   Lee YY, 2012, J FOOD COMPOS ANAL, V27, P70, DOI 10.1016/j.jfca.2012.03.010
   Lemieux I, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113501
   Li LK, 2018, NUTRIENTS, V10, DOI 10.3390/nu10060777
   MEGRAW RE, 1979, CLIN CHEM, V25, P273
   Mithila M, 2015, J FOOD SCI TECH MYS, V52, P6735, DOI 10.1007/s13197-014-1691-1
   Nwichi S O, 2012, Afr J Med Med Sci, V41 Suppl, P39
   Pereira E, 2019, FOOD CHEM, V280, P110, DOI 10.1016/j.foodchem.2018.12.068
   Repo-Carrasco R, 2003, FOOD REV INT, V19, P179, DOI 10.1081/FRI-120018884
   SATOH K, 1978, CLIN CHIM ACTA, V90, P37
   SCHRIEWER H, 1984, J CLIN CHEM CLIN BIO, V22, P35
   Shen YB, 2022, MOLECULES, V27, DOI 10.3390/molecules27082453
   Tang Y, 2016, J AGR FOOD CHEM, V64, P1103, DOI 10.1021/acs.jafc.5b05414
   Tang Y, 2015, FOOD CHEM, V174, P502, DOI 10.1016/j.foodchem.2014.11.040
   Vega-Gálvez A, 2010, J SCI FOOD AGR, V90, P2541, DOI 10.1002/jsfa.4158
   WATSON D, 1960, CLIN CHIM ACTA, V5, P637, DOI 10.1016/0009-8981(60)90004-8
NR 30
TC 1
Z9 1
U1 1
U2 2
PU CONSEJO SUPERIOR INVESTIGACIONES CIENTIFICAS-CSIC
PI MADRID
PA Editorial CSIC, C/VITRUVIO 8, 28006 MADRID, SPAIN
SN 0017-3495
EI 1988-4214
J9 GRASAS ACEITES
JI Grasas Aceites
PD JAN-MAR
PY 2024
VL 75
IS 1
AR e542
DI 10.3989/gya.1104222
PG 11
WC Chemistry, Applied; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology
GA NZ9O3
UT WOS:001204395000001
OA gold
DA 2025-06-11
ER

PT J
AU Marycz, K
   Michalak, I
   Kornicka, K
AF Marycz, Krzysztof
   Michalak, Izabela
   Kornicka, Katarzyna
TI Advanced nutritional and stem cells approaches to prevent equine
   metabolic syndrome
SO RESEARCH IN VETERINARY SCIENCE
LA English
DT Review
DE Metabolic syndrome; Algae; Mesenchymal stem cells; Diabetes; Insulin
   resistance; Obesity; Nutrition
ID BIOLOGICAL FEED SUPPLEMENT; MESENCHYMAL STROMAL CELLS; PANCREATIC
   BETA-CELLS; INSULIN-RESISTANCE; OXIDATIVE STRESS; SKELETAL-MUSCLE;
   ADIPOSE-TISSUE; FATTY-ACID; CHEMICAL-COMPOSITION; BIOSORPTION PROCESS
AB Horses metabolic disorders have become an important problem of modern veterinary medicine. Pathological obesity, insulin resistance and predisposition toward laminitis are associated with Equine Metabolic Syndrome (EMS). Based on pathogenesis of EMS, dietary and cell therapy management may significantly reduce development of this disorder. Special attention has been paid to the diet supplementation with highly bioavailable minerals and mesenchymal stem cells (MSC) which increase insulin sensitivity. In nutrition, there is a great interests in natural algae enriched via biosorption process with micro-and macroelements. In the case of cellular therapy, metabolic condition of engrafted cells may be crucial for the effectiveness of the therapy. Although, recent studies indicated on MSC deterioration in EMS individuals. Here, we described the combined nutritional and stem cells therapy for the EMS treatment. Moreover, we specified in details how EMS affects the adipose derived stem cells (ASC) population. Presented here, combined kind of therapy-an innovative and cutting edge approach of metabolic disorders treatment may become a new gold standard in personalized veterinary medicine.
C1 [Marycz, Krzysztof; Kornicka, Katarzyna] Wroclaw Univ Environm & Life Sci, Dept Expt Biol, PL-50630 Wroclaw, Poland.
   [Marycz, Krzysztof; Kornicka, Katarzyna] Wroclaw Res Ctr EIT, PL-54066 Wroclaw, Poland.
   [Michalak, Izabela] Wroclaw Univ Sci & Technol, Fac Chem, Dept Adv Mat Technol, Smoluchowskiego 25, PL-50372 Wroclaw, Poland.
C3 Wroclaw University of Environmental & Life Sciences; Wroclaw University
   of Science & Technology
RP Kornicka, K (corresponding author), Wroclaw Univ Environm & Life Sci, Dept Expt Biol, CK Norwida 27B, PL-50375 Wroclaw, Poland.
EM katarzyna.kornicka@upwr.edu.pl
RI Michalak, Izabela/P-3770-2015
OI Michalak, Izabela/0000-0001-8084-9642
FU National Science Centre in Poland [2015/18/ E/NZ9/00607,
   2016/21/B/NZ7/01111]; Wroclaw Centre of Biotechnology, programme the
   Leading National Research Centre (KNOW)
FX This manuscript was supported by the project entitled "The effect of
   bioactive algae enriched by biosorption on the certain minerals such as
   Cr(III), Mg(II) and Mn(II) on the status of glucose in the course of
   metabolic syndrome horses. Evaluation in vitro and in vivo" (2015/18/
   E/NZ9/00607) and "Modulation mitochondrial metabolism and dynamics and
   tageting DNA methylation of adipose derived mesenchymal stromal stem
   cell (ASC) using resveratrol and 5-azacytydin as a therapeutic strategy
   in the course of Equine metabolic syndrome (EMS)" (2016/21/B/NZ7/01111)
   attributed by The National Science Centre in Poland. Publication was
   supported by Wroclaw Centre of Biotechnology, programme the Leading
   National Research Centre (KNOW) for years 2014-2018.
CR Abdi R, 2008, DIABETES, V57, P1759, DOI 10.2337/db08-0180
   Aguilera-Morales M, 2005, J FOOD COMPOS ANAL, V18, P79, DOI 10.1016/j.jfca.2003.12.012
   Amado LC, 2005, P NATL ACAD SCI USA, V102, P11474, DOI 10.1073/pnas.0504388102
   Anderson RA, 1997, REGUL TOXICOL PHARM, V26, pS35, DOI 10.1006/rtph.1997.1136
   Awad O, 2005, STEM CELLS, V23, P575, DOI 10.1634/stemcells.2004-0185
   Bach D, 2003, J BIOL CHEM, V278, P17190, DOI 10.1074/jbc.M212754200
   Bailey SR, 2007, JAVMA-J AM VET MED A, V231, P1365, DOI 10.2460/javma.231.9.1365
   Baksh D, 2007, STEM CELLS, V25, P1384, DOI 10.1634/stemcells.2006-0709
   Barone AAL, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/383685
   Basinska K, 2015, J VET SCI, V16, P113, DOI [10.4142/jvs.2015.16.1.113, 10.4142/jvs.2015.16.1.107]
   Baynes JW, 1999, DIABETES, V48, P1, DOI 10.2337/diabetes.48.1.1
   Berman DM, 2010, DIABETES, V59, P2558, DOI 10.2337/db10-0136
   Bhansali A, 2009, STEM CELLS DEV, V18, P1407, DOI 10.1089/scd.2009.0164
   Biddle AS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0077599
   Borowitzka MA. ME, 2009, J Appl Phycol, V21, P747, DOI [10.1007/s10811-009-9467-0, DOI 10.1007/S10811-009-9467-0]
   Boya P, 2005, MOL CELL BIOL, V25, P1025, DOI 10.1128/MCB.25.3.1025-1040.2005
   Brown GC, 2001, IUBMB LIFE, V52, P189, DOI 10.1080/15216540152845993
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Chamberlain G, 2007, STEM CELLS, V25, P2739, DOI 10.1634/stemcells.2007-0197
   Chameroy KA, 2011, EQUINE VET J, V43, P494, DOI 10.1111/j.2042-3306.2010.00302.x
   CHAO TT, 1976, CELL TISSUE RES, V168, P239, DOI 10.1007/BF00215880
   Chen ZF, 2011, AUTOPHAGY, V7, P12, DOI 10.4161/auto.7.1.13607
   Chojnacka K, 2007, WORLD J MICROB BIOT, V23, P1139, DOI 10.1007/s11274-006-9344-9
   Collino F, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011803
   Cuervo AM, 2005, AUTOPHAGY, V1, P131, DOI 10.4161/auto.1.3.2017
   Cusi K, 2010, CURR DIABETES REP, V10, P306, DOI 10.1007/s11892-010-0122-6
   Meirelles LDS, 2006, J CELL SCI, V119, P2204, DOI 10.1242/jcs.02932
   de Laat MA, 2010, EQUINE VET J, V42, P129, DOI 10.2746/042516409X475779
   De Marchi E, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/564961
   Del Bue M, 2008, VET RES COMMUN, V32, pS51, DOI 10.1007/s11259-008-9093-3
   Dominici M, 2006, CYTOTHERAPY, V8, P315, DOI 10.1080/14653240600855905
   El-Said GF, 2013, ENVIRON MONIT ASSESS, V185, P6089, DOI 10.1007/s10661-012-3009-y
   Ezquer FE, 2008, BIOL BLOOD MARROW TR, V14, P631, DOI 10.1016/j.bbmt.2008.01.006
   Falanga V, 2007, TISSUE ENG, V13, P1299, DOI 10.1089/ten.2006.0278
   Fiorina P, 2009, J IMMUNOL, V183, P993, DOI 10.4049/jimmunol.0900803
   Frank N, 2011, VET CLIN N AM-EQUINE, V27, P73, DOI 10.1016/j.cveq.2010.12.004
   Frank N, 2009, J EQUINE VET SCI, V29, P259, DOI 10.1016/j.jevs.2009.04.183
   FREESTONE JF, 1992, EQUINE VET J, V24, P187, DOI 10.1111/j.2042-3306.1992.tb02812.x
   French KR, 2004, EQUINE VET J, V36, P242, DOI 10.2746/0425164044877134
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Geor R, 2009, VET IMMUNOL IMMUNOP, V129, P151, DOI 10.1016/j.vetimm.2008.11.012
   Geor RJ, 2009, VET CLIN N AM-EQUINE, V25, P51, DOI 10.1016/j.cveq.2009.02.001
   Gniewosz M, 2007, ACTA SCI POLON-TECHN, V6, P57
   Goldman S, 2010, AUTOPHAGY, V6, P179, DOI 10.4161/auto.6.1.10814
   Green DR, 2014, CELL, V157, P65, DOI 10.1016/j.cell.2014.02.049
   Grzesiak Jakub, 2011, Int J Stem Cells, V4, P99
   Guilherme A, 2008, NAT REV MOL CELL BIO, V9, P367, DOI 10.1038/nrm2391
   Hamza E, 2011, IMMUNOLOGY, V134, P292, DOI 10.1111/j.1365-2567.2011.03489.x
   Hess TM, 2012, J ANIM SCI, V90, P3023, DOI 10.2527/jas.2011-4412
   Hess TM, 2013, J EQUINE VET SCI, V33, P446, DOI 10.1016/j.jevs.2012.07.007
   Hoffman RM, 2001, J ANIM SCI, V79, P500
   Hong CJ, 2016, BRAIN RES, V1649, P166, DOI 10.1016/j.brainres.2016.02.048
   Huang LH, 2007, TOXICOLOGY, V242, P109, DOI 10.1016/j.tox.2007.09.015
   Huntington P., 2008, Australian Equine Veterinarian, V27, P40
   Jesmin S, 2003, ARTERIOSCL THROM VAS, V23, P2021, DOI 10.1161/01.ATV.0000094235.78783.D1
   Johnson P.J., 2004, COMPEND CONTIN ED PR, V26
   Johnson PJ, 2010, VET CLIN N AM-EQUINE, V26, P239, DOI 10.1016/j.cveq.2010.04.004
   Johnson RJ, 2013, J EQUINE VET SCI, V33, P120, DOI 10.1016/j.jevs.2012.05.004
   Juan CC, 2004, AM J PHYSIOL-ENDOC M, V287, pE948, DOI 10.1152/ajpendo.00536.2003
   Jumabay M, 2015, J CELL PHYSIOL, V230, P2821, DOI 10.1002/jcp.25012
   Kaniuk NA, 2007, DIABETES, V56, P930, DOI 10.2337/db06-1160
   Kelley DE, 2002, DIABETES, V51, P2944, DOI 10.2337/diabetes.51.10.2944
   Khan M, 2011, STEM CELLS DEV, V20, P67, DOI 10.1089/scd.2009.0397
   Khan WS, 2010, KNEE, V17, P369, DOI 10.1016/j.knee.2009.12.003
   Kornicka K, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/309169
   Kwon DS, 2008, INT WOUND J, V5, P453, DOI 10.1111/j.1742-481X.2007.00408.x
   Lee RH, 2006, P NATL ACAD SCI USA, V103, P17438, DOI 10.1073/pnas.0608249103
   Li Z, 2004, CELL, V119, P873, DOI 10.1016/j.cell.2004.11.003
   Lin GT, 2009, STEM CELLS DEV, V18, P1399, DOI 10.1089/scd.2009.0010
   Longland AC, 2006, J NUTR, V136, p2099S, DOI 10.1093/jn/136.7.2099S
   Lu DB, 2011, DIABETES RES CLIN PR, V92, P26, DOI 10.1016/j.diabres.2010.12.010
   MacArtain P, 2007, NUTR REV, V65, P535, DOI [10.1301/nr.2007.dec.535-543, 10.1111/j.1753-4887.2007.tb00278.x]
   Mack SJ, 2014, VET REC, V174, P452, DOI 10.1136/vr.102074
   Martin SD, 2014, BBA-GEN SUBJECTS, V1840, P1303, DOI 10.1016/j.bbagen.2013.09.019
   Marycz K, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19010165
   Marycz K, 2017, MAR DRUGS, V15, DOI 10.3390/md15120385
   Marycz K, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/3718468
   Marycz K, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/4710326
   Marycz K, 2016, J CELL MOL MED, V20, P2384, DOI 10.1111/jcmm.12932
   Marycz K, 2014, PAK VET J, V34, P189
   Mazur-Bialy AI, 2017, LIFE SCI, V178, P9, DOI 10.1016/j.lfs.2017.04.010
   Mazur-Bialy AI, 2016, MOLECULES, V21, DOI 10.3390/molecules21121724
   Mensink M, 2007, INT J OBESITY, V31, P1302, DOI 10.1038/sj.ijo.0803567
   Michalak I, 2011, J ANIM PHYSIOL AN N, V95, P374, DOI 10.1111/j.1439-0396.2010.01065.x
   Michalak I, 2008, J SCI FOOD AGR, V88, P1178, DOI 10.1002/jsfa.3195
   Michalak I, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18030479
   Michalak I, 2015, ENG LIFE SCI, V15, P160, DOI 10.1002/elsc.201400191
   Michalak I, 2013, APPL BIOCHEM BIOTECH, V170, P1389, DOI 10.1007/s12010-013-0269-0
   Michalak I, 2010, ENG LIFE SCI, V10, P209, DOI 10.1002/elsc.200900039
   Michalak I, 2009, INT J ENVIRON AN CH, V89, P583, DOI 10.1080/03067310802627213
   Minamino T, 2009, NAT MED, V15, P1082, DOI 10.1038/nm.2014
   MOHAZZABH KM, 1994, AM J PHYSIOL, V266, pH2568, DOI 10.1152/ajpheart.1994.266.6.H2568
   MOORE JN, 1979, AM J VET RES, V40, P722
   Moore-Colyer MJS, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0114079
   Mootha VK, 2003, NAT GENET, V34, P267, DOI 10.1038/ng1180
   Morgan R, 2015, VET REC, V177, P173, DOI 10.1136/vr.103226
   Mortensen M, 2011, AUTOPHAGY, V7, P1069, DOI 10.4161/auto.7.9.15886
   Nauta AJ, 2007, BLOOD, V110, P3499, DOI 10.1182/blood-2007-02-069716
   Nawrocka D, 2017, MAR DRUGS, V15, DOI 10.3390/md15080237
   Nicpon J, 2013, POL J VET SCI, V16, P753, DOI 10.2478/pjvs-2013-0107
   Nielsen BD, 2014, COMP EXERC PHYSIOL, V10, P159, DOI 10.3920/CEP140006
   Nielsen BD, 2010, J EQUINE VET SCI, V30, P419, DOI 10.1016/j.jevs.2010.07.003
   Ohnishi S, 2007, J MOL CELL CARDIOL, V42, P88, DOI 10.1016/j.yjmcc.2006.10.003
   Ortiz J, 2006, FOOD CHEM, V99, P98, DOI 10.1016/j.foodchem.2005.07.027
   Ötles S, 2001, J AOAC INT, V84, P1708
   Petersen KF, 2004, NEW ENGL J MED, V350, P664, DOI 10.1056/NEJMoa031314
   Porada Christopher D, 2006, Curr Stem Cell Res Ther, V1, P365
   Prockop DJ, 1997, SCIENCE, V276, P71, DOI 10.1126/science.276.5309.71
   Rahavi H, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/878535
   Rota M, 2006, CIRC RES, V99, P42, DOI 10.1161/01.RES.0000231289.63468.08
   Saeid A, 2013, J APPL PHYCOL, V25, P667, DOI 10.1007/s10811-012-9901-6
   SAKURAI T, 1988, FEBS LETT, V236, P406, DOI 10.1016/0014-5793(88)80066-8
   SCHOFIELD R, 1978, BLOOD CELLS, V4, P7
   Shields R., 2012, J ANIM SCI, V21, P23, DOI 10.14512/tatup.21.1.23
   Smieszek A, 2017, MAR DRUGS, V15, DOI 10.3390/md15030065
   Steppan CM, 2002, TRENDS ENDOCRIN MET, V13, P18, DOI 10.1016/S1043-2760(01)00522-7
   Sun LY, 2013, J BIOMED SCI, V20, DOI 10.1186/1423-0127-20-53
   Sun Y, 2007, CHINESE MED J-PEKING, V120, P771, DOI 10.1097/00029330-200705010-00007
   Taintor JS, 2014, J EQUINE VET SCI, V34, P1197, DOI 10.1016/j.jevs.2014.07.007
   Tchkonia T, 2010, AGING CELL, V9, P667, DOI 10.1111/j.1474-9726.2010.00608.x
   Tuhy L, 2014, APPL BIOCHEM BIOTECH, V174, P1376, DOI 10.1007/s12010-014-1074-0
   Volarevic V, 2010, AUTOIMMUNITY, V43, P255, DOI 10.3109/08916930903305641
   Walder K, 2005, DIABETOLOGIA, V48, P459, DOI 10.1007/s00125-005-1675-9
   Waller A.P., 2011, J VET INTERN MED
   Wang XH, 2009, STEM CELLS, V27, P3021, DOI 10.1002/stem.230
   Witkowska Z, 2014, FOOD CHEM, V151, P86, DOI 10.1016/j.foodchem.2013.11.023
   Witkowska Z, 2015, J FOOD SCI TECH MYS, V52, P6484, DOI 10.1007/s13197-014-1696-9
   Wu YJ, 2007, STEM CELLS, V25, P2648, DOI 10.1634/stemcells.2007-0226
   Xie CF, 2015, SCI REP-UK, V5, DOI 10.1038/srep13975
   Youle RJ, 2012, SCIENCE, V337, P1062, DOI 10.1126/science.1219855
   Zdravkovic N, 2009, MOL IMMUNOL, V47, P28, DOI 10.1016/j.molimm.2008.12.023
   Zhang N, 2008, EXP CLIN ENDOCR DIAB, V116, P104, DOI 10.1055/s-2007-985154
   Zhu SJ, 2011, J SURG RES, V168, P213, DOI 10.1016/j.jss.2009.10.008
   Zieliñska A, 2009, J SCI FOOD AGR, V89, P2292, DOI 10.1002/jsfa.3723
NR 134
TC 13
Z9 15
U1 1
U2 35
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0034-5288
EI 1532-2661
J9 RES VET SCI
JI Res. Vet. Sci.
PD JUN
PY 2018
VL 118
BP 115
EP 125
DI 10.1016/j.rvsc.2018.01.015
PG 11
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA GJ1WU
UT WOS:000435059400018
PM 29421480
DA 2025-06-11
ER

PT J
AU Ghibu, S
   Decea, N
   Morgovan, C
   Mogosan, C
AF Ghibu, Steliana
   Decea, Nicoleta
   Morgovan, Claudiu
   Mogosan, Cristina
TI AN EXPERIMENTAL MODEL TO INDUCE METABOLIC SYNDROME IN RATS. THE FRUCTOSE
   - ENRICHED DIET
SO FARMACIA
LA English
DT Article
DE metabolic syndrome; rat fructose-enriched diet; research animal model
ID OXIDATIVE STRESS
AB The objective of this study was to induce metabolic syndrome (MS) in rats by means of a fructose-enriched diet (F, 60%). Twenty male Sprague-Dawley rats were randomized into 2 groups and fed for 3 months with standard chow (Control group) or with standard chow supplemented with fructose (F, 60%). After their sacrifice, blood was drawn and the following biochemical parameters were determined from the centrifuged plasma: triglycerides and malondialdehyde (MDA) - a marker of lipid peroxidation. The fructose diet induced a significant increase in glycaemia (5.60 +/- 0.07 vs 7.22 +/- 0.13 mM, p < 0.001), in systolic blood pressure (SBP 113.66 +/- 1.14 vs 130.61 +/- 0.80 mmHg, p < 0.001) and in the triglyceride values (61.86 +/- 4.86 vs 331.20 +/- 23.15 mg/dL, p < 0.001), without significant modification of rat body weight. Moreover, the plasma MDA level was 1.38 times higher in fructose-fed rats. Our results suggest that this experimental model could be used to induce metabolic alterations, such as hypertension, hyperglycaemia and dyslipidemia, alterations associated to lipid peroxidation.
C1 [Ghibu, Steliana; Mogosan, Cristina] Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, Dept Pharmacol Physiol & Physiopathol, Cluj Napoca, Romania.
   [Decea, Nicoleta] Iuliu Hatieganu Univ Med & Pharm, Fac Med, Dept Physiol, Cluj Napoca, Romania.
   [Morgovan, Claudiu] Vasile Goldis Western Univ Arad, Dept Pharm, Arad, Romania.
C3 Iuliu Hatieganu University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy; Vasile Goldis Western University of
   Arad
RP Morgovan, C (corresponding author), Vasile Goldis Western Univ Arad, Dept Pharm, Arad, Romania.
EM claudiumorgovan@yahoo.com
RI Ghibu, Steliana/X-4723-2019; Mogosan, Cristina/H-9901-2016; Morgovan,
   Claudiu/C-4748-2011
OI Ghibu, Steliana/0000-0003-2247-4613; Morgovan,
   Claudiu/0000-0003-2730-8729
FU CNCSIS - UEFISCDI [PNII - PD 473/2010]
FX This work was supported by CNCSIS - UEFISCDI, project number PNII - PD
   473/2010.
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Leao LSCD, 2011, ARQ BRAS CARDIOL, V97, P260
   Day Caroline, 2007, Diab Vasc Dis Res, V4, P32, DOI 10.3132/dvdr.2007.003
   Esterbauer H, 1994, METHOD ENZYMOL, V186, P406
   Vázquez-Vela MEF, 2008, ARCH MED RES, V39, P715, DOI 10.1016/j.arcmed.2008.09.005
   Holvoet P, 2008, Verh K Acad Geneeskd Belg, V70, P193
   Korandji C, 2011, ATHEROSCLEROSIS, V214, P310, DOI 10.1016/j.atherosclerosis.2010.11.014
   Miricescu D, 2011, FARMACIA, V59, P329
   Pepene CE, 2011, EUR J ENDOCRINOL, V164, P61, DOI 10.1530/EJE-10-0720
   Roche HM, 2005, P NUTR SOC, V64, P371, DOI 10.1079/PNS2005445
   Russell JC, 2006, CARDIOVASC PATHOL, V15, P318, DOI 10.1016/j.carpath.2006.09.001
   Stanhope KL, 2010, ANN NY ACAD SCI, V1190, P15, DOI 10.1111/j.1749-6632.2009.05266.x
   Tran LT, 2009, MOL CELL BIOCHEM, V332, P145, DOI 10.1007/s11010-009-0184-4
   Virgolici B, 2011, FARMACIA, V59, P216
   Wiernsperger N, 2011, CLINICS, V65, P729
NR 15
TC 9
Z9 9
U1 0
U2 22
PU SOC STINTE FARMACEUTICE ROMANIA
PI BUCURESTI
PA BUCURESTI, STR TRAIAN VUIA 6, SECT 1, BUCURESTI, 020956, ROMANIA
SN 0014-8237
J9 FARMACIA
JI Farmacia
PD MAR-APR
PY 2013
VL 61
IS 2
BP 420
EP 426
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 128ZD
UT WOS:000317807300020
DA 2025-06-11
ER

PT J
AU Leung, LYL
   Chan, SMN
   Tam, HL
   Wong, ESW
AF Leung, Leona Yuen-Ling
   Chan, Sidney Man-Ngai
   Tam, Hon-Lon
   Wong, Emily Sze-Wan
TI Astaxanthin Influence on Health Outcomes of Adults at Risk of Metabolic
   Syndrome: A Systematic Review and Meta-Analysis
SO NUTRIENTS
LA English
DT Review
DE astaxanthin; cardiometabolic disease; metabolic syndrome; systematic
   review; meta-analysis
ID OXIDATIVE STRESS
AB The use of medication is effective in managing metabolic syndrome (MetS), but side effects have led to increased attention on using nutraceuticals and supplements. Astaxanthin shows positive effects in reducing the risk of MetS, but results from individual studies are inconclusive. This systematic review summarizes the latest evidence of astaxanthin in adults with risk factors of MetS. A systematic search of English and Chinese randomized controlled trials in 14 electronic databases from inception to 30 June 2021 was performed. Two reviewers independently screened the titles and abstracts, and conducted full-text review, quality appraisal, and extraction of data. Risk of bias was assessed by PEDro. A total of 7 studies met the inclusion criteria with 321 participants. Six studies were rated to have excellent methodological quality, while the remaining one was rated at good. Results show marginal effects of astaxanthin on reduction in total cholesterol and systolic blood pressure, and a significant attenuating effect on low-density lipoprotein cholesterol. Further robust evidence is needed to examine the effects of astaxanthin in adults at risk of MetS.
C1 [Leung, Leona Yuen-Ling] Ronin Inst, Montclair, NJ 07043 USA.
   [Leung, Leona Yuen-Ling] Hong Kong Food Sci & Technol Assoc, Hong Kong, Peoples R China.
   [Leung, Leona Yuen-Ling] Canadian Acad Independent Scholars, Vancouver, BC V6B 5K3, Canada.
   [Chan, Sidney Man-Ngai; Wong, Emily Sze-Wan] Hong Kong Metropolitan Univ, Sch Sci & Technol, Hong Kong, Peoples R China.
   [Tam, Hon-Lon] Kiang Wu Nursing Coll Macau, Dept Educ, Macau 999078, Peoples R China.
   [Tam, Hon-Lon] Hong Kong Polytech Univ, Sch Nursing, Hong Kong, Peoples R China.
C3 Hong Kong Metropolitan University; Kiang Wu Nursing College of Macau;
   Hong Kong Polytechnic University
RP Wong, ESW (corresponding author), Hong Kong Metropolitan Univ, Sch Sci & Technol, Hong Kong, Peoples R China.; Tam, HL (corresponding author), Kiang Wu Nursing Coll Macau, Dept Educ, Macau 999078, Peoples R China.; Tam, HL (corresponding author), Hong Kong Polytech Univ, Sch Nursing, Hong Kong, Peoples R China.
EM leonaleung@ronininstitute.org; mnchan@hkmu.edu.hk; alantam@kwnc.edu.mo;
   eswwong@hkmu.edu.hk
RI Leung, Leona/AHE-8456-2022; Wong, Emily/IAP-2216-2023; Tam, Hon
   Lon/W-1371-2019
OI Tam, Hon Lon/0000-0003-0344-6262; Leung, Yuen Ling/0000-0003-2704-7805;
   Wong, Emily Sze Wan/0000-0001-7030-2299
CR [Anonymous], 2020, J PHYSIOTHER, V66, P59, DOI 10.1016/j.jphys.2019.08.005
   [Anonymous], 2004, CHIN J DIAB, V12, P156, DOI 10.3321/j.issn:1006-6187.2004.03.002
   Aromataris E, 2020, JBI MAN EVID SYNTH, DOI [10.46658/JBIMES-20-01, DOI 10.46658/JBIMES-20-12, DOI 10.46658/JBIMES-20-01]
   Brendler T, 2019, PHYTOTHER RES, V33, P3090, DOI 10.1002/ptr.6514
   Chen H, 2012, BIOMETRICS, V68, P1278, DOI 10.1111/j.1541-0420.2012.01761.x
   Choi HD, 2011, PHYTOTHER RES, V25, P1813, DOI 10.1002/ptr.3494
   Coombes JS, 2016, AM J CLIN NUTR, V103, P283, DOI 10.3945/ajcn.115.115477
   Cornier MA, 2008, ENDOCR REV, V29, P777, DOI 10.1210/er.2008-0024
   Davinelli S, 2018, NUTRIENTS, V10, DOI 10.3390/nu10040522
   Donoso A, 2021, PHARMACOL RES, V166, DOI 10.1016/j.phrs.2021.105479
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Haswell C, 2021, METABOLITES, V11, DOI 10.3390/metabo11060338
   Hess PL, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.117.006103
   Higgins JPT, 2003, BMJ-BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557
   Hou XH, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057319
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Macdermid Joy C, 2012, Hand (N Y), V7, P1, DOI 10.1007/s11552-011-9381-1
   Mallappa Rashmi H, 2012, Indian J Endocrinol Metab, V16, P20, DOI 10.4103/2230-8210.91178
   Mashhadi NS, 2018, ASIA PAC J CLIN NUTR, V27, P341, DOI 10.6133/apjcn.052017.11
   Nakagawa K, 2011, BRIT J NUTR, V105, P1563, DOI 10.1017/S0007114510005398
   Nasser M, 2020, AM J PUBLIC HEALTH, V110, P753, DOI 10.2105/AJPH.2020.305609
   Ouzzani M, 2016, SYST REV-LONDON, V5, DOI 10.1186/s13643-016-0384-4
   Pearson A., 2007, EVIDENCE BASED CLIN
   Probst P, 2016, SYST REV-LONDON, V5, DOI 10.1186/s13643-016-0226-4
   Regufe Virginia M G, 2020, Porto Biomed J, V5, pe101, DOI 10.1097/j.pbj.0000000000000101
   Sarkkinen ES, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0935-x
   Shirouchi B, 2019, J OLEO SCI, V68, P517, DOI 10.5650/jos.ess19084
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Swarup S., 2022, METABOLIC SYNDROME
   Ursoniu S, 2015, ARCH MED SCI, V11, P253, DOI 10.5114/aoms.2015.50960
   Vergara D, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.617859
   Xia W, 2020, PHARMACOL RES, V161, DOI 10.1016/j.phrs.2020.105113
   Yanai H, 2008, INTEGR BLOOD PRESS C, V1, P1
   Yoshida H, 2010, ATHEROSCLEROSIS, V209, P520, DOI 10.1016/j.atherosclerosis.2009.10.012
   Zhang Y, 2016, BMC CARDIOVASC DISOR, V16, DOI 10.1186/s12872-016-0398-9
NR 35
TC 13
Z9 13
U1 2
U2 8
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2022
VL 14
IS 10
AR 2050
DI 10.3390/nu14102050
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1R2NN
UT WOS:000803212100001
PM 35631193
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fuentes, E
   Fuentes, F
   Vilahur, G
   Badimon, L
   Palomo, I
AF Fuentes, Eduardo
   Fuentes, Francisco
   Vilahur, Gemma
   Badimon, Lina
   Palomo, Ivan
TI Mechanisms of Chronic State of Inflammation as Mediators That Link Obese
   Adipose Tissue and Metabolic Syndrome
SO MEDIATORS OF INFLAMMATION
LA English
DT Review
ID TUMOR-NECROSIS-FACTOR; CCAAT/ENHANCER BINDING-PROTEIN; ADIPONECTIN
   GENE-EXPRESSION; C-REACTIVE PROTEIN; CARDIOVASCULAR RISK-FACTORS; PRIMES
   HUMAN MONOCYTES; TNF-ALPHA THERAPY; GAMMA PPAR-GAMMA; OXIDATIVE STRESS;
   CIRCULATING ADIPONECTIN
AB The metabolic syndrome is a cluster of cardiometabolic alterations that include the presence of arterial hypertension, insulin resistance, dyslipidemia, and abdominal obesity. Obesity is associated with a chronic inflammatory response, characterized by abnormal adipokine production, and the activation of proinflammatory signalling pathways resulting in the induction of several biological markers of inflammation. Macrophage and lymphocyte infiltration in adipose tissue may contribute to the pathogenesis of obesity-mediated metabolic disorders. Adiponectin can either act directly on macrophages to shift polarization and/or prime human monocytes into alternative M2-macrophages with anti-inflammatory properties. Meanwhile, the chronic inflammation in adipose tissue is regulated by a series of transcription factors, mainly PPARs and C/EBPs, that in conjunction regulate the expression of hundreds of proteins that participate in the metabolism and storage of lipids and, as such, the secretion by adipocytes. Therefore, the management of the metabolic syndrome requires the development of new therapeutic strategies aimed to alter the main genetic pathways involved in the regulation of adipose tissue metabolism.
C1 [Fuentes, Eduardo; Palomo, Ivan] Univ Talca, Fac Hlth Sci, Dept Clin Biochem & Immunohematol, Immunol & Haematol Lab,Interdisciplinary Excellen, Talca, Chile.
   [Fuentes, Eduardo; Palomo, Ivan] CEAP, Talca, Chile.
   [Fuentes, Francisco] Univ Catolica Maule, Fac Med, Escuela Med, Santiago, Chile.
   [Vilahur, Gemma; Badimon, Lina] Inst Carlos III, CiberOBN, Hosp Santa Creu & Sant Pau, ICCC CSIC,Ctr Invest Cardiovasc, Barcelona, Spain.
C3 Universidad de Talca; Universidad Catolica del Maule; Hospital of Santa
   Creu i Sant Pau; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEROBN; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC -
   Institut Catala de Ciencies Cardiovasculars (ICCC)
RP Palomo, I (corresponding author), Univ Talca, Fac Hlth Sci, Dept Clin Biochem & Immunohematol, Immunol & Haematol Lab,Interdisciplinary Excellen, Talca, Chile.
EM ipalomo@utalca.cl
RI BADIMON, LINA/S-2950-2019; Palomo, Iván/I-4321-2018; JIMENEZ,
   FRANCISCO/G-4311-2016; Fuentes, Eduardo/I-2889-2017; Badimon,
   Lina/O-4711-2014
OI Fuentes, Eduardo/0000-0003-0099-4108; Badimon, Lina/0000-0002-9162-2459;
   Palomo, Ivan/0000-0002-9618-8778
FU CONICYT REGIONAL/GORE, Programa de Investigacion de Excelencia
   Interdisciplinaria en Envejecimiento Saludable (PIEI-ES)
   [MAULE/CEAP/R09I2001]; Fondecyt, Chile [1130216]; PNS from the Spanish
   Ministry of Science [SAF2010-16549]; Insituto Carlos-III [CIBEROBN06];
   Science and Education Spanish Ministry (MICINN, Spain) [RyC-2009-5495]
FX This work was funded by the CONICYT REGIONAL/GORE MAULE/CEAP/R09I2001,
   Programa de Investigacion de Excelencia Interdisciplinaria en
   Envejecimiento Saludable (PIEI-ES), and supported by Grant no. 1130216
   (I.P., M.G., R.M., M.A., J.C.) from Fondecyt, Chile, by PNS
   SAF2010-16549 (to Lina Badimon) from the Spanish Ministry of Science and
   CIBEROBN06 Insituto Carlos-III (to Lina Badimon). The authors thank
   Fundacion Jesus Serra, Barcelona, for their continuous support. Gemma
   Vilahur is a recipient of a Grant from the Science and Education Spanish
   Ministry (RyC-2009-5495, MICINN, Spain).
CR Ahima RS, 2006, OBESITY, V14, P242, DOI 10.1038/oby.2006.317
   Ahn J, 2007, BIOCHEM BIOPH RES CO, V364, P972, DOI 10.1016/j.bbrc.2007.10.109
   Aledo R, 2012, REV ESP CARDIOL, V65, P807, DOI [10.1016/j.recesp.2012.03.013, 10.1016/j.rec.2012.03.012]
   Aprahamian T, 2009, J IMMUNOL, V182, P340, DOI 10.4049/jimmunol.182.1.340
   Araki K, 2008, ONCOGENE, V27, P5696, DOI 10.1038/onc.2008.184
   Badimon L, 2012, THROMB RES, V130, pS12, DOI 10.1016/j.thromres.2012.08.262
   Badimon L, 2012, CARDIOVASC RES, V96, P172, DOI 10.1093/cvr/cvs226
   Badimon L, 2011, THROMB HAEMOSTASIS, V105, pS34, DOI 10.1160/THS10-11-0717
   Barreda R., 1991, CRITICAL REV DIAGNOS, V33, P29
   Bastard JP, 2006, EUR CYTOKINE NETW, V17, P4
   Bennett CE, 2010, DIABETES VASC DIS RE, V7, P195, DOI 10.1177/1479164110366274
   Bondia-Pons I, 2012, J PHYSIOL BIOCHEM, V68, P701, DOI 10.1007/s13105-012-0154-2
   Bouhlel MA, 2007, CELL METAB, V6, P137, DOI 10.1016/j.cmet.2007.06.010
   Bouloumié A, 2005, CURR OPIN CLIN NUTR, V8, P347, DOI 10.1097/01.mco.0000172571.41149.52
   Bruce CR, 2004, AM J PHYSIOL-ENDOC M, V287, pE616, DOI 10.1152/ajpendo.00150.2004
   Chakrabarti SK, 2009, OBESITY, V17, P1657, DOI 10.1038/oby.2009.192
   Chandrasekar B, 2008, J BIOL CHEM, V283, P4200, DOI 10.1074/jbc.M708142200
   Chatterjee R, 2011, J MOL ENDOCRINOL, V46, P175, DOI 10.1530/JME-10-0172
   Choi HM, 2009, ARTHRITIS RES THER, V11, DOI 10.1186/ar2844
   Cinti S, 2005, J LIPID RES, V46, P2347, DOI 10.1194/jlr.M500294-JLR200
   Cnop M, 2003, DIABETOLOGIA, V46, P459, DOI 10.1007/s00125-003-1074-z
   Collins SC, 2007, DIABETOLOGIA, V50, P555, DOI 10.1007/s00125-006-0534-7
   Conde J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0052533
   Dobrian AD, 2010, BIOCHEM BIOPH RES CO, V403, P485, DOI 10.1016/j.bbrc.2010.11.065
   Dyck DJ, 2009, APPL PHYSIOL NUTR ME, V34, P396, DOI 10.1139/H09-037
   Engeli S, 2003, DIABETES, V52, P942, DOI 10.2337/diabetes.52.4.942
   Fain JN, 2004, ENDOCRINOLOGY, V145, P2273, DOI 10.1210/en.2003-1336
   Ferraz-Amaro I, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/710928
   Findeisen HM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0018532
   Flier JS, 2004, CELL, V116, P337, DOI 10.1016/S0092-8674(03)01081-X
   Fraser JK, 2006, TRENDS BIOTECHNOL, V24, P150, DOI 10.1016/j.tibtech.2006.01.010
   Fujiki K, 2009, BMC BIOL, V7, DOI 10.1186/1741-7007-7-38
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gasparyan AY, 2011, CURR PHARM DESIGN, V17, P47
   Gómez R, 2011, NAT REV RHEUMATOL, V7, P528, DOI 10.1038/nrrheum.2011.107
   Gong FY, 2009, INT J OBESITY, V33, P1023, DOI 10.1038/ijo.2009.141
   Gonzalez-Gay MA, 2008, CLIN EXP RHEUMATOL, V26, P596
   Gonzalez-Gay MA, 2008, CLIN EXP RHEUMATOL, V26, P311
   Gonzalez-Gay MA, 2006, CLIN EXP RHEUMATOL, V24, P373
   Gonzalez-Gay MA, 2009, CLIN EXP RHEUMATOL, V27, P222
   Gonzalez-Juanatey C, 2006, CLIN EXP RHEUMATOL, V24, P309
   Grundy SM, 2004, J CLIN ENDOCR METAB, V89, P2595, DOI 10.1210/jc.2004-0372
   Gupta Sanjiv, 2006, Indian Heart J, V58, P149
   Guri AJ, 2008, J NUTR BIOCHEM, V19, P216, DOI 10.1016/j.jnutbio.2007.02.010
   Hajer GR, 2008, EUR HEART J, V29, P2959, DOI 10.1093/eurheartj/ehn387
   Halabi CM, 2008, CELL METAB, V7, P215, DOI 10.1016/j.cmet.2007.12.008
   Hara K, 2005, DIABETOLOGIA, V48, P1307, DOI 10.1007/s00125-005-1806-3
   He ZB, 2004, AM J PHYSIOL-ENDOC M, V287, pE424, DOI 10.1152/ajpendo.00568.2003
   Heikkinen S, 2007, BBA-MOL CELL BIOL L, V1771, P999, DOI 10.1016/j.bbalip.2007.03.006
   Heilbronn LK, 2008, CURR PHARM DESIGN, V14, P1225, DOI 10.2174/138161208784246153
   Herman MA, 2012, NATURE, V484, P333, DOI 10.1038/nature10986
   Vera RH, 2013, THROMB HAEMOSTASIS, V109, P319, DOI 10.1160/TH12-09-0696
   Vera RH, 2012, ARTERIOSCL THROM VAS, V32, P2141, DOI 10.1161/ATVBAHA.112.255281
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   HOTAMISLIGIL GS, 1995, J CLIN INVEST, V95, P2409, DOI 10.1172/JCI117936
   Iizuka K, 2008, ENDOCR J, V55, P617, DOI 10.1507/endocrj.K07E-110
   Im SS, 2006, BIOCHEM J, V399, P131, DOI 10.1042/BJ20060696
   Ishii M, 2009, BLOOD, V114, P3244, DOI 10.1182/blood-2009-04-217620
   Jay MA, 2007, CURR DIABETES REV, V3, P33, DOI 10.2174/157339907779802067
   Kadowaki Takashi, 2007, Novartis Found Symp, V286, P164
   Kaidashev I P, 2012, Fiziol Zh, V58, P93
   Kallio P, 2007, AM J CLIN NUTR, V85, P1417, DOI 10.1093/ajcn/85.5.1417
   Kawashima Y, 2009, DIABETOLOGIA, V52, P1434, DOI 10.1007/s00125-009-1378-8
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Kern PA, 2001, AM J PHYSIOL-ENDOC M, V280, pE745
   Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2548, DOI 10.1210/jc.2004-0395
   Ketsawatsomkron P, 2010, J BIOL CHEM, V285, P9311, DOI 10.1074/jbc.R109.025031
   Khan RS, 2012, CIRC-HEART FAIL, V5, P340, DOI 10.1161/CIRCHEARTFAILURE.111.964031
   Kim OY, 2006, CLIN CHIM ACTA, V370, P63, DOI 10.1016/j.cca.2006.01.021
   Kintscher U, 2008, ARTERIOSCL THROM VAS, V28, P1304, DOI 10.1161/ATVBAHA.108.165100
   Kita A, 2005, BIOCHEM BIOPH RES CO, V331, P484, DOI 10.1016/j.bbrc.2005.03.205
   Klimcakova E, 2011, DIABETOLOGIA, V54, P876, DOI 10.1007/s00125-010-2014-3
   Koshfishi C, 2008, GENE, V424, P141, DOI 10.1016/j.gene.2008.07.039
   Krakoff J, 2003, DIABETES CARE, V26, P1745, DOI 10.2337/diacare.26.6.1745
   Krupinski J, 2007, VASC HEALTH RISK MAN, V3, P405
   Kumada M, 2003, ARTERIOSCL THROM VAS, V23, P85, DOI 10.1161/01.ATV.0000048856.22331.50
   Lago F, 2007, NAT CLIN PRACT RHEUM, V3, P716, DOI 10.1038/ncprheum0674
   Lago F, 2009, TRENDS BIOCHEM SCI, V34, P500, DOI 10.1016/j.tibs.2009.06.008
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lindström T, 2006, CLIN ENDOCRINOL, V65, P776, DOI 10.1111/j.1365-2265.2006.02666.x
   Lovren F, 2010, AM J PHYSIOL-HEART C, V299, pH656, DOI 10.1152/ajpheart.00115.2010
   Lowell BB, 1999, CELL, V99, P239, DOI 10.1016/S0092-8674(00)81654-2
   Luconi M, 2010, STEROIDS, V75, P585, DOI 10.1016/j.steroids.2009.10.012
   Lumeng CN, 2007, J CLIN INVEST, V117, P175, DOI 10.1172/JCI29881
   Lumeng CN, 2011, J CLIN INVEST, V121, P2111, DOI 10.1172/JCI57132
   Lumeng CN, 2008, DIABETES, V57, P3239, DOI 10.2337/db08-0872
   Madsen EL, 2008, EUR J ENDOCRINOL, V158, P179, DOI 10.1530/EJE-07-0721
   Mandal P, 2011, J BIOL CHEM, V286, P13460, DOI 10.1074/jbc.M110.204644
   Mandal P, 2010, HEPATOLOGY, V51, P1420, DOI 10.1002/hep.23427
   Mantell BS, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019831
   Gómez J, 2008, GLYCOCONJUGATE J, V25, P573, DOI 10.1007/s10719-008-9118-8
   Matsubara M, 2002, EUR J ENDOCRINOL, V147, P173, DOI 10.1530/eje.0.1470173
   Mracek T, 2010, CLIN ENDOCRINOL, V72, P334, DOI 10.1111/j.1365-2265.2009.03658.x
   Mujica V, 2010, J AM SOC HYPERTENS, V4, P148, DOI 10.1016/j.jash.2010.02.008
   Mujica V, 2008, NUTR J, V7, DOI 10.1186/1475-2891-7-14
   Nasarre L., 2012, ACTA DIABETOLOGICA
   Nishimura Satoshi, 2009, Discov Med, V8, P55
   Nishimura S, 2009, NAT MED, V15, P914, DOI 10.1038/nm.1964
   Odegaard JI, 2008, CELL METAB, V7, P496, DOI 10.1016/j.cmet.2008.04.003
   Odegaard JI, 2007, NATURE, V447, P1116, DOI 10.1038/nature05894
   Ohashi K, 2010, J BIOL CHEM, V285, P6153, DOI 10.1074/jbc.M109.088708
   Ohmura K, 2010, ARTERIOSCL THROM VAS, V30, P193, DOI 10.1161/ATVBAHA.109.198614
   OMRAN SA, 1991, BLOOD COAGUL FIBRIN, V2, P659, DOI 10.1097/00001721-199110000-00012
   Oñate B, 2012, FASEB J, V26, P4327, DOI 10.1096/fj.12-207217
   Orio F, 2007, J ENDOCRINOL INVEST, V30, P70, DOI 10.1007/BF03347399
   Ouchi N, 2003, CIRCULATION, V107, P671, DOI 10.1161/01.CIR.0000055188.83694.B3
   Ouchi N, 1999, CIRCULATION, V100, P2473, DOI 10.1161/01.CIR.100.25.2473
   Pérez MP, 2012, MOL MED REP, V5, P1135, DOI 10.3892/mmr.2012.785
   Palomo I, 2006, INT J MOL MED, V18, P969
   Palomo I, 2011, NITRIC OXIDE-BIOL CH, V24, P224, DOI 10.1016/j.niox.2011.03.002
   Palomo Ivan, 2010, Front Biosci (Schol Ed), V2, P194
   Palomo I, 2008, MOL MED REP, V1, P179
   Palomo IG, 2009, MOL MED REP, V2, P481, DOI 10.3892/mmr_00000125
   Palomo IG, 2009, MOL MED REP, V2, P253, DOI 10.3892/mmr_00000092
   Park SK, 2004, DIABETES, V53, P2757, DOI 10.2337/diabetes.53.11.2757
   Pittas AG, 2004, J CLIN ENDOCR METAB, V89, P447, DOI 10.1210/jc.2003-031005
   POPE RM, 1994, J CLIN INVEST, V94, P1449, DOI 10.1172/JCI117482
   Qiao LP, 2006, J BIOL CHEM, V281, P39915, DOI 10.1074/jbc.M607215200
   Qiao LP, 2005, DIABETES, V54, P1744, DOI 10.2337/diabetes.54.6.1744
   Ramji DP, 2002, BIOCHEM J, V365, P561, DOI 10.1042/BJ20020508
   Rausch ME, 2008, INT J OBESITY, V32, P451, DOI 10.1038/sj.ijo.0803744
   Bernal-Lopez MR, 2013, DIABETES CARE, V36, P1006, DOI 10.2337/dc12-1030
   Ruan H, 2002, DIABETES, V51, P3176, DOI 10.2337/diabetes.51.11.3176
   Ryan AS, 2003, DIABETES CARE, V26, P2383, DOI 10.2337/diacare.26.8.2383
   Rydén M, 2002, J BIOL CHEM, V277, P1085, DOI 10.1074/jbc.M109498200
   Salmenniemi U, 2005, INT J OBESITY, V29, P1464, DOI 10.1038/sj.ijo.0803041
   Salmenniemi U, 2005, J CLIN ENDOCR METAB, V90, P4216, DOI 10.1210/jc.2004-2289
   Salmenniemi U, 2004, CIRCULATION, V110, P3842, DOI 10.1161/01.CIR.0000150391.38660.9B
   Sankhla M, 2012, CLIN LAB, V58, P385
   Sans S, 2013, ANN MED, V45, P97, DOI 10.3109/07853890.2012.679958
   Sato Y, 2007, DIABETOLOGIA, V50, P481, DOI 10.1007/s00125-006-0480-4
   Satoh M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030568
   Sattar N, 2003, CIRCULATION, V108, P414, DOI 10.1161/01.CIR.0000080897.52664.94
   Sekine O, 2002, J BIOL CHEM, V277, P36631, DOI 10.1074/jbc.M206266200
   Shimomura I, 1996, NAT MED, V2, P800, DOI 10.1038/nm0796-800
   Shoelson SE, 2009, NAT MED, V15, P373, DOI 10.1038/nm0409-373
   Simons PJ, 2007, J ENDOCRINOL, V192, P289, DOI 10.1677/JOE-06-0047
   Skalicky J, 2008, CLIN CHEM LAB MED, V46, P499, DOI 10.1515/CCLM.2008.096
   STEINER G, 1963, ANN NY ACAD SCI, V110, P749, DOI 10.1111/j.1749-6632.1963.tb15795.x
   Sugii S, 2011, FEBS LETT, V585, P2121, DOI 10.1016/j.febslet.2011.05.007
   Tangirala RK, 2001, J BIOL CHEM, V276, P261, DOI 10.1074/jbc.M003324200
   Trayhurn P, 2004, BRIT J NUTR, V92, P347, DOI 10.1079/BJN20041213
   Tsuchida A, 2005, DIABETES, V54, P3358, DOI 10.2337/diabetes.54.12.3358
   Turu MM, 2008, BMC CELL BIOL, V9, DOI 10.1186/1471-2121-9-47
   van Dijk SJ, 2009, AM J CLIN NUTR, V90, P1656, DOI 10.3945/ajcn.2009.27792
   Vernochet C, 2009, MOL CELL BIOL, V29, P4714, DOI 10.1128/MCB.01899-08
   Villalta SA, 2009, HUM MOL GENET, V18, P482, DOI 10.1093/hmg/ddn376
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Xue B, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017386
   Ye JP, 2007, AM J PHYSIOL-ENDOC M, V293, pE1118, DOI 10.1152/ajpendo.00435.2007
   You TJ, 2005, AM J PHYSIOL-ENDOC M, V288, pE741, DOI 10.1152/ajpendo.00419.2004
   Yue L, 2008, ENDOCRINOLOGY, V149, P4051, DOI 10.1210/en.2008-0340
   Yue L, 2009, J BIOL CHEM, V284, P10453, DOI 10.1074/jbc.M808482200
   Yue LL, 2004, J BIOL CHEM, V279, P47626, DOI 10.1074/jbc.M408461200
   Zamboni M, 2007, INT J OBESITY, V31, P1104, DOI 10.1038/sj.ijo.0803563
   Zappalà G, 2009, BIOCHEM BIOPH RES CO, V382, P785, DOI 10.1016/j.bbrc.2009.03.112
   Zoico E, 2010, J GERONTOL A-BIOL, V65, P295, DOI 10.1093/gerona/glp155
NR 158
TC 152
Z9 164
U1 0
U2 22
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2013
VL 2013
AR 136584
DI 10.1155/2013/136584
PG 11
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA 169NE
UT WOS:000320786200001
PM 23843680
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Swiatkiewicz, I
   Nuszkiewicz, J
   Wroblewska, J
   Nartowicz, M
   Sokolowski, K
   Sutkowy, P
   Rajewski, P
   Buczkowski, K
   Chudzinska, M
   Manoogian, ENC
   Taub, PR
   Wozniak, A
AF Swiatkiewicz, Iwona
   Nuszkiewicz, Jaroslaw
   Wroblewska, Joanna
   Nartowicz, Malgorzata
   Sokolowski, Kamil
   Sutkowy, Pawel
   Rajewski, Pawel
   Buczkowski, Krzysztof
   Chudzinska, Malgorzata
   Manoogian, Emily N. C.
   Taub, Pam R.
   Wozniak, Alina
TI Feasibility and Cardiometabolic Effects of Time-Restricted Eating in
   Patients with Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE time-restricted eating; metabolic syndrome; abdominal obesity; body
   weight; elevated blood pressure; impaired glucose metabolism;
   cardiometabolic risks; circadian rhythm; eating window; m-health
   applications
ID CARDIOVASCULAR RISK; HEART-DISEASE; HEALTH; MANAGEMENT; WEIGHT; TRENDS;
   IMPACT; POPULATION; PREVALENCE; PATTERNS
AB Metabolic syndrome (MetS) and a prolonged daily eating window (EW) are associated with circadian rhythm disruption and increased cardiometabolic risk. Misalignment between circadian timing system and daily rhythms of food intake adversely impacts metabolic regulatory mechanisms and cardiovascular function. Restricting the daily EW by imposing an eating-fasting cycle through time-restricted eating (TRE) can restore robust circadian rhythms, support cellular metabolism, and improve cardiometabolic health. The aim of this study was to assess a feasibility of 12-week TRE intervention with self-selected 10 h EW and effects of TRE on EW duration, cardiometabolic outcomes, daily rhythms of behavior, and wellbeing in Polish patients with MetS and EW >= 14 h/day. Dietary intake was monitored with a validated myCircadianClock application (mCC app). Adherence to TRE defined as the proportion of days recorded with mCC app in which participants satisfied 10-h TRE was the primary outcome. A total of 26 patients (aged 45 +/- 13 years, 62% women, 3.3 +/- 0.5 MetS criteria, EW 14 +/- 1.5 h/day) were enrolled. Coexistence of increased waist circumference (WC) (96% of patients), elevated fasting plasma glucose (FPG) (77%), and elevated blood pressure (BP) (69%) was the most common MetS pattern (50%). TRE intervention (mean duration of 81.6 +/- 12.6 days) led to reducing daily EW by 28% (p < 0.0001). Adherence to TRE was 87 +/- 13%. Adherence to logging food intake on mCC app during TRE was 70 +/- 27%. Post TRE, a decrease in body weight (2%, 1.7 +/- 3.6 kg, p = 0.026), body mass index (BMI) (1%, 0.5 +/- 1.2 kg/m(2), p = 0.027), WC (2%, 2.5 +/- 3.9 cm, p = 0.003), systolic BP (4%, 4.8 +/- 9.0 mmHg, p = 0.012), FPG (4%, 3.8 +/- 6.9 mg/dL, p = 0.037), glycated hemoglobin (4%, 0.2 +/- 0.4%, p = 0.011), mean fasting glucose level from continuous glucose monitor (CGM) (4%, 4.0 +/- 6.1 mg/dL, p = 0.002), and sleepiness score (25%, 1.9 +/- 3.2 points, p = 0043) were observed. A significant decrease in body weight (2%), BMI (2%), WC (3%), mean CGM fasting glucose (6%), sleepiness score (27%), and depression score (60%) was found in patients with mean post-TRE EW <= 10 h/day (58% of total), and not in patients with EW > 10 h/day. Adherence to TRE was higher in patients with post-TRE EW <= 10 h/day vs. patients with EW > 10 h/day (94 +/- 6% vs. 77 +/- 14%, p = 0.003). Our findings indicate that 10-h TRE was feasible in the European MetS population. TRE resulted in reducing daily EW and improved cardiometabolic outcomes and wellbeing in patients with MetS and prolonged EW. Use of the mCC app can aid in implementing TRE. This pilot clinical trial provides exploratory data that are a basis for a large-scale randomized controlled trial to determine the efficacy and sustainability of TRE for reducing cardiometabolic risks in MetS populations. Further research is needed to investigate the mechanisms of TRE effects, including its impact on circadian rhythm disruption.
C1 [Swiatkiewicz, Iwona; Taub, Pam R.] Univ Calif San Diego, Div Cardiovasc Med, La Jolla, CA 92037 USA.
   [Nuszkiewicz, Jaroslaw; Wroblewska, Joanna; Sokolowski, Kamil; Sutkowy, Pawel; Wozniak, Alina] Nicolaus Copernicus Univ, Dept Med Biol & Biochem, Coll Medicum, PL-85092 Bydgoszcz, Poland.
   [Nartowicz, Malgorzata] Prof Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Clin Nutr Team, PL-85796 Bydgoszcz, Poland.
   [Rajewski, Pawel] Ctr Obes & Metab Disorders Treatment, PL-85676 Bydgoszcz, Poland.
   [Rajewski, Pawel] Univ Hlth Sci Bydgoszcz, Fac Hlth Sci, PL-87800 Bydgoszcz, Poland.
   [Buczkowski, Krzysztof] Nicolaus Copernicus Univ Torun, Dept Family Med, Coll Medicum Bydgoszcz, Torun, Poland.
   [Chudzinska, Malgorzata] Nicolaus Copernicus Univ, Dept Neurosurg & Neurol, Coll Medicum, Bydgoszcz, Poland.
   [Manoogian, Emily N. C.] Salk Inst Biol Studies, Regulatory Biol Lab, La Jolla, CA 92037 USA.
C3 University of California System; University of California San Diego;
   Nicolaus Copernicus University; Nicolaus Copernicus University; Nicolaus
   Copernicus University; Salk Institute
RP Swiatkiewicz, I (corresponding author), Univ Calif San Diego, Div Cardiovasc Med, La Jolla, CA 92037 USA.
EM iswiatkiewicz@health.ucsd.edu; jnuszkiewicz@cm.umk.pl;
   jwroblewskapraca@gmail.com; nartowiczgosia@gmail.com;
   sokolowskikamil@tlen.pl; p.sutkowy@cm.umk.pl; rajson@wp.pl;
   buczkowskik@cm.umk.pl; malgorzata.chudzinska1@wp.pl;
   emanoogian@salk.edu; ptaub@health.ucsd.edu; al1103@cm.umk.pl
RI Wróblewska, Joanna/G-8607-2014; Chudzinska, Malgorzata/AAZ-7227-2021;
   Swiatkiewicz, Iwona/H-4279-2014; Buczkowski, Krzysztof/H-7696-2014;
   Wozniak, Alina/H-4699-2014; Nuszkiewicz, Jaroslaw/AAI-6787-2021;
   Sutkowy, Pawel/G-9282-2014
OI Taub, Pam/0000-0002-0684-0655; Manoogian, Emily
   Nicole/0000-0001-9718-9310; Wroblewska, Joanna/0000-0002-8188-8296;
   Buczkowski, Krzysztof/0000-0002-7700-0952; Rajewski,
   Pawel/0000-0001-9796-8840; Wozniak, Alina/0000-0002-4492-4796;
   Nuszkiewicz, Jaroslaw/0000-0003-1378-5065; Sutkowy,
   Pawel/0000-0002-3479-7738
FX For the TREMNIOS pilot clinical trial, the mCC app was customized and a
   sub-study dashboard on the server side was created by E.N.C.M. at the
   Salk Institute for Biological Studies, La Jolla, CA, USA. E.N.C.M. from
   the Salk Institute, who is also a member of the research team of this
   study, is the administrator of data collected on the server using the
   mCC app. We thank Satchin Panda from the Salk Institute for Biological
   Studies, La Jolla, CA, USA for valuable discussions about this study.
CR Ackermann RT, 2015, AM J PUBLIC HEALTH, V105, P2328, DOI 10.2105/AJPH.2015.302641
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Anton SD, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071500
   Antoni R, 2018, J NUTR SCI, V7, DOI 10.1017/jns.2018.13
   Beltrán-Sánchez H, 2013, J AM COLL CARDIOL, V62, P697, DOI 10.1016/j.jacc.2013.05.064
   Borushek A., 2022, CalorieKing Calorie, Fat and Carbohydrate
   Cahill LE, 2013, CIRCULATION, V128, P337, DOI 10.1161/CIRCULATIONAHA.113.001474
   Castro-Barquero S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12102983
   Cederroth CR, 2019, CELL METAB, V30, P238, DOI 10.1016/j.cmet.2019.06.019
   Chaix A, 2019, ANNU REV NUTR, V39, P291, DOI 10.1146/annurev-nutr-082018-124320
   Chellappa SL, 2019, TRENDS ENDOCRIN MET, V30, P767, DOI 10.1016/j.tem.2019.07.008
   Chow LS, 2020, OBESITY, V28, P860, DOI [10.1002/oby.22756, 10.1002/oby.22785]
   Cienfuegos S, 2020, CELL METAB, V32, P366, DOI 10.1016/j.cmet.2020.06.018
   de Cabo R, 2019, NEW ENGL J MED, V381, P2541, DOI 10.1056/NEJMra1905136
   Eckel RH, 2010, LANCET, V375, P181, DOI 10.1016/S0140-6736(09)61794-3
   Ervin R Bethene, 2009, Natl Health Stat Report, P1
   Feinman RD, 2015, NUTRITION, V31, P1, DOI 10.1016/j.nut.2014.06.011
   Fontana L, 2018, NAT REV CARDIOL, V15, P566, DOI 10.1038/s41569-018-0026-8
   Gabel Kelsey, 2018, Nutr Healthy Aging, V4, P345, DOI 10.3233/NHA-170036
   Gill S, 2015, CELL METAB, V22, P789, DOI 10.1016/j.cmet.2015.09.005
   Gupta NJ, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0172852
   Ha K, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102437
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Hutchison AT, 2019, OBESITY, V27, P724, DOI 10.1002/oby.22449
   International Diabetes Federation, Consensus Worldwide Defnition of the Metabolic Syndrome
   Jamshed H, 2022, JAMA INTERN MED, V182, P953, DOI 10.1001/jamainternmed.2022.3050
   Jamshed H, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061234
   Kant AK, 2015, J ACAD NUTR DIET, V115, P50, DOI 10.1016/j.jand.2014.06.354
   Katula JA, 2013, AM J PREV MED, V44, pS324, DOI 10.1016/j.amepre.2012.12.015
   Kesztyüs D, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122854
   Lowe DA, 2020, JAMA INTERN MED, V180, P1491, DOI 10.1001/jamainternmed.2020.4153
   Martin SS, 2024, CIRCULATION, V149, pE347, DOI 10.1161/CIR.0000000000001209
   Mason IC, 2020, DIABETOLOGIA, V63, P462, DOI 10.1007/s00125-019-05059-6
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Murray CJL, 2020, LANCET, V396, P1223, DOI [10.1016/S0140-6736(20)30752-2, 10.1016/S0140-6736(20)30925-9]
   Panda S, 2016, SCIENCE, V354, P1008, DOI 10.1126/science.aah4967
   Parr EB, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020505
   Peeke PM, 2021, NUTR DIABETES, V11, DOI 10.1038/s41387-021-00149-0
   Pérez-Martínez P, 2017, NUTR REV, V75, P307, DOI 10.1093/nutrit/nux014
   Phelps NH, 2024, LANCET, V403, P1027, DOI 10.1016/S0140-6736(23)02750-2
   Phillips NE, 2021, NUTRIENTS, V13, DOI 10.3390/nu13031042
   Pot GK, 2016, P NUTR SOC, V75, P475, DOI 10.1017/S0029665116000239
   Prasad M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13072148
   Ravussin E, 2019, OBESITY, V27, P1244, DOI 10.1002/oby.22518
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Scuteri A, 2015, EUR J PREV CARDIOL, V22, P486, DOI 10.1177/2047487314525529
   Sperling LS, 2015, J AM COLL CARDIOL, V66, P1050, DOI 10.1016/j.jacc.2015.06.1328
   Steger FL, 2023, OBESITY, V31, P96, DOI 10.1002/oby.23614
   Stenvers DJ, 2019, NAT REV ENDOCRINOL, V15, P75, DOI 10.1038/s41574-018-0122-1
   Suliga E, 2017, NUTRIENTS, V9, DOI 10.3390/nu9121366
   Sutton EF, 2018, CELL METAB, V27, P1212, DOI 10.1016/j.cmet.2018.04.010
   Swiatkiewicz I, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24076382
   Swiatkiewicz I, 2021, NUTRIENTS, V13, DOI 10.3390/nu13113883
   Swiatkiewicz I, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020346
   Swiatkiewicz I, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010221
   Sygnowska E, 2012, KARDIOL POL, V70, P718
   Virani SS, 2020, CIRCULATION, V141, pE139, DOI 10.1161/CIR.0000000000000757
   Visseren FLJ, 2021, EUR HEART J, V42, P3227, DOI 10.1093/eurheartj/ehab484
   Vos T, 2020, LANCET, V396, P1562
   Wilkinson MJ, 2020, CELL METAB, V31, P92, DOI 10.1016/j.cmet.2019.11.004
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
   Zarrinpar A, 2016, TRENDS ENDOCRIN MET, V27, P69, DOI 10.1016/j.tem.2015.11.007
   Zomer E, 2016, OBES REV, V17, P1001, DOI 10.1111/obr.12433
NR 65
TC 3
Z9 3
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2024
VL 16
IS 12
AR 1802
DI 10.3390/nu16121802
PG 26
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA WT3V1
UT WOS:001257094500001
PM 38931157
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Li, YH
   Zhang, ZM
   Zhang, ZM
   Zheng, NN
   Ding, XD
AF Li, Yunhao
   Zhang, Zhanming
   Zhang, Zheming
   Zheng, Ningning
   Ding, Xudong
TI Empagliflozin, a sodium-glucose cotransporter inhibitor enhancing
   mitochondrial action and cardioprotection in metabolic syndrome
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Article
DE cardiomyocyte; empagliflozin; metabolic syndrome; mitochondria
ID CHAIN AMINO-ACIDS; DNA COPY NUMBER; CARDIAC NA+/H+ EXCHANGER;
   PERIPHERAL-BLOOD; SGLT2 INHIBITORS; SKELETAL-MUSCLE; HEART-FAILURE;
   FAILING HEART; DYSFUNCTION; ENERGY
AB Metabolic syndrome (MetS) has a large clinical population nowadays, usually due to excessive energy intake and lack of exercise. During MetS, excess nutrients stress the mitochondria, resulting in relative hypoxia in tissues and organs, even when blood supply is not interrupted or reduced, making mitochondrial dysfunction a central pathogenesis of cardiovascular disease in the MetS. Sodium-glucose cotransporter 2 inhibitors were designed as a hyperglycemic drug that acts on the renal tubules to block sugar reabsorption in primary urine. Recently they have been shown to have anti-inflammatory and other protective effects on cardiomyocytes in MetS, and have also been recommended in the latest heart failure guidelines as a routine therapy. Among these inhibitors, empagliflozin shows better clinical promise due to less influence from glomerular filtration rate. This review focuses on the mitochondrial mechanisms of empagliflozin, which underlie the anti-inflammatory and recover cellular functions in MetS cardiomyocytes, including stabilizing calcium concentration, mediating metabolic reprogramming, maintaining homeostasis of mitochondrial quantity and quality, stable mitochondrial DNA copy number, and repairing damaged mitochondrial DNA.
C1 [Li, Yunhao; Zhang, Zheming] China Med Univ, Grad Sch, Shenyang, Peoples R China.
   [Li, Yunhao] Gen Hosp Northern Theater Command, Dept Cardiol, Shenyang, Peoples R China.
   [Zhang, Zhanming] Univ Hong Kong, Fac Sci, Hong Kong, Peoples R China.
   [Zhang, Zheming] China Med Univ, Hosp 1, Dept Thorac Surg, Shenyang, Peoples R China.
   [Zheng, Ningning] China Med Univ, Coll Basic Med Sci, Dept Pathophysiol, Shenyang, Peoples R China.
   [Ding, Xudong] China Med Univ, Dept Anesthesiol, Shengjing Hosp, 36 Sanhao St, Shenyang, Peoples R China.
C3 China Medical University; University of Hong Kong; China Medical
   University; China Medical University; China Medical University
RP Ding, XD (corresponding author), China Med Univ, Dept Anesthesiol, Shengjing Hosp, 36 Sanhao St, Shenyang, Peoples R China.
EM dingxd@sj-hospital.org
RI Zhang, Zhan-Ming/IZQ-3053-2023; Zheng, Ningning/KHU-0389-2024; Li,
   Yunhao/HCI-0205-2022
OI Li, Yunhao/0000-0002-5359-2930
FU Natural Science Foundation of Liaoning Province [2022-MS-236]; Natural
   Science Foundation of Liaoning Province of China
FX The work was supported by the Natural Science Foundation of Liaoning
   Province of China (FUND#2022-MS-236).
CR Abdulrahman N, 2022, MOL CELL BIOCHEM, V477, P1865, DOI 10.1007/s11010-022-04411-6
   Adingupu DD, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0820-6
   Agius R, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.886957
   Ait-Aissa K, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-43761-y
   Al-Shamasi A, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222312677
   Alicic RZ, 2019, DIABETES, V68, P248, DOI 10.2337/dbi18-0007
   Andreadou I, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.01077
   Anker SD, 2021, NEW ENGL J MED, V385, P1451, DOI 10.1056/NEJMoa2107038
   [Anonymous], DIABETES, V68, P1094
   Aragón-Herrera A, 2019, BIOCHEM PHARMACOL, V170, DOI 10.1016/j.bcp.2019.113677
   Aubert G, 2016, CIRCULATION, V133, P698, DOI 10.1161/CIRCULATIONAHA.115.017355
   Baartscheer A, 2017, DIABETOLOGIA, V60, P568, DOI 10.1007/s00125-016-4134-x
   Barclay CJ, 2008, J PHYSIOL-LONDON, V586, P5037, DOI 10.1113/jphysiol.2008.163246
   Basit F, 2017, CELL DEATH DIS, V8, DOI 10.1038/cddis.2017.133
   Bayes-Genis A, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-91546-z
   Belosludtsev KN, 2021, MITOCHONDRION, V59, P246, DOI 10.1016/j.mito.2021.06.008
   Berger C, 2020, PFLUG ARCH EUR J PHY, V472, P1249, DOI 10.1007/s00424-020-02383-4
   Bessho R, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-51343-1
   Bhattacharya S, 2014, ATHEROSCLEROSIS, V232, P191, DOI 10.1016/j.atherosclerosis.2013.10.036
   Bode D, 2021, CARDIOVASC DIABETOL, V20, DOI 10.1186/s12933-020-01208-z
   Cai C, 2022, MOL METAB, V64, DOI 10.1016/j.molmet.2022.101553
   Cai C, 2022, REDOX BIOL, V52, DOI 10.1016/j.redox.2022.102288
   Cesari M, 2016, CIRC-CARDIOVASC IMAG, V9, DOI 10.1161/CIRCIMAGING.116.004815
   Chang Xing, 2022, Metabolism, V137, P155313, DOI 10.1016/j.metabol.2022.155313
   Chen XQ, 2019, BIOCHEM BIOPH RES CO, V516, P37, DOI 10.1016/j.bbrc.2019.06.015
   Chen Y, 2011, CIRC RES, V109, P1327, DOI 10.1161/CIRCRESAHA.111.258723
   Collins LV, 2004, J LEUKOCYTE BIOL, V75, P995, DOI 10.1189/jlb.0703328
   DeFronzo RA, 2021, NAT REV NEPHROL, V17, P319, DOI 10.1038/s41581-021-00393-8
   Doehner W, 2022, EUR HEART J, V43, P3435, DOI 10.1093/eurheartj/ehac320
   Durak A, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0790-0
   Eirin A, 2016, HYPERTENSION, V68, P401, DOI 10.1161/HYPERTENSIONAHA.116.07849
   Fang CJ, 2016, PROTEIN CELL, V7, P11, DOI 10.1007/s13238-015-0222-9
   Fazzini F, 2021, J INTERN MED, V290, P190, DOI 10.1111/joim.13242
   Ferrannini E, 2014, J CLIN INVEST, V124, P499, DOI 10.1172/JCI72227
   Ferrannini G, 2015, DIABETES CARE, V38, P1730, DOI 10.2337/dc15-0355
   Fralick M, 2021, J GEN INTERN MED, V36, P2601, DOI 10.1007/s11606-020-06561-z
   Galloway CA, 2015, ANTIOXID REDOX SIGN, V22, P1545, DOI 10.1089/ars.2015.6293
   Gomes LC, 2011, NAT CELL BIOL, V13, P589, DOI 10.1038/ncb2220
   Goulopoulou S, 2012, CLIN SCI, V123, P429, DOI 10.1042/CS20120130
   Han JX, 2023, ACTA PHARMACOL SIN, V44, P1161, DOI 10.1038/s41401-022-01031-0
   Hawley SA, 2016, DIABETES, V65, P2784, DOI 10.2337/db16-0058
   Hegyi B, 2021, BASIC RES CARDIOL, V116, DOI 10.1007/s00395-021-00900-9
   Hopfner KP, 2020, NAT REV MOL CELL BIO, V21, P501, DOI 10.1038/s41580-020-0244-x
   Horton JL, 2019, JCI INSIGHT, V4, DOI 10.1172/jci.insight.124079
   Huang C., 2023, J CLIN ENDOCRINOLOGY, V109, P406
   Hung CS, 2022, TRANSL RES, V239, P58, DOI 10.1016/j.trsl.2021.08.003
   Inzucchi SE, 2018, DIABETES CARE, V41, P356, DOI 10.2337/dc17-1096
   Ishikawa H, 2008, NATURE, V455, P674, DOI 10.1038/nature07317
   Jiang K, 2022, PROTEIN CELL, V13, P336, DOI 10.1007/s13238-020-00809-4
   Kelley DE, 2002, DIABETES, V51, P2944, DOI 10.2337/diabetes.51.10.2944
   Kim I, 2007, ARCH BIOCHEM BIOPHYS, V462, P245, DOI 10.1016/j.abb.2007.03.034
   Kim JA, 2008, CIRC RES, V102, P401, DOI 10.1161/CIRCRESAHA.107.165472
   Korbut AI, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21082987
   Kosiborod MN, 2022, CIRCULATION, V146, P279, DOI 10.1161/CIRCULATIONAHA.122.059725
   Koves TR, 2008, CELL METAB, V7, P45, DOI 10.1016/j.cmet.2007.10.013
   Kowaltowski AJ, 2009, FREE RADICAL BIO MED, V47, P333, DOI 10.1016/j.freeradbiomed.2009.05.004
   Koyani CN, 2020, PHARMACOL RES, V158, DOI 10.1016/j.phrs.2020.104870
   Lai L, 2014, CIRC-HEART FAIL, V7, P1022, DOI 10.1161/CIRCHEARTFAILURE.114.001469
   Lambert R, 2015, J AM HEART ASSOC, V4, DOI 10.1161/JAHA.115.002183
   Lee H, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-22083-6
   Lee H, 2020, NAT CELL BIOL, V22, DOI 10.1038/s41556-020-0461-8
   Li AX, 2022, HEART FAIL REV, V27, P1387, DOI 10.1007/s10741-021-10109-6
   Li CG, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0816-2
   Li YH, 2021, DIABET METAB SYND OB, V14, P4631, DOI 10.2147/DMSO.S336882
   Liu M, 2021, MOL ONCOL, V15, P2084, DOI 10.1002/1878-0261.12936
   Liu T, 2008, CIRC RES, V103, P279, DOI 10.1161/CIRCRESAHA.108.175919
   Liu T, 2014, CIRC RES, V115, P44, DOI 10.1161/CIRCRESAHA.115.303062
   Lu QY, 2023, FREE RADICAL BIO MED, V195, P89, DOI 10.1016/j.freeradbiomed.2022.12.088
   Lu QG, 2020, MOL CELL ENDOCRINOL, V501, DOI 10.1016/j.mce.2019.110642
   Lyu Y, 2023, EUR J PHARMACOL, V942, DOI 10.1016/j.ejphar.2023.175531
   Ma S, 2022, N-S ARCH PHARMACOL, V395, P945, DOI 10.1007/s00210-022-02243-1
   Macha S, 2015, CLIN THER, V37, P1789, DOI 10.1016/j.clinthera.2015.06.003
   Makrecka-Kuka M, 2020, CARDIOVASC DRUG THER, V34, P791, DOI 10.1007/s10557-020-06989-9
   Malik Afshan N, 2009, Diabetes Res Clin Pract, V86, pe22, DOI 10.1016/j.diabres.2009.07.002
   Mazidi M, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.116.004007
   Menne J, 2019, PLOS MED, V16, DOI [10.1371/journal.pmed.1002983, 10.1371/journal.pmed.1002983.r001, 10.1371/journal.pmed.1002983.r002, 10.1371/journal.pmed.1002983.r003, 10.1371/journal.pmed.1002983.r004, 10.1371/journal.pmed.1002983.r005]
   Min J, 2023, LIFE SCI, V312, DOI 10.1016/j.lfs.2022.121207
   Mizuno M, 2018, PHYSIOL REP, V6, DOI 10.14814/phy2.13741
   Moellmann J, 2020, BBA-MOL BASIS DIS, V1866, DOI 10.1016/j.bbadis.2020.165807
   Morciano G, 2022, CARDIOVASC RES, V118, P2548, DOI 10.1093/cvr/cvab267
   Murashige D, 2020, SCIENCE, V370, P364, DOI 10.1126/science.abc8861
   Mustroph J, 2018, ESC HEART FAIL, V5, P642, DOI 10.1002/ehf2.12336
   Mustroph J, 2017, PHARMACOL THERAPEUT, V176, P22, DOI 10.1016/j.pharmthera.2016.10.006
   Nakahira K, 2011, NAT IMMUNOL, V12, P222, DOI 10.1038/ni.1980
   Neinast M, 2019, ANNU REV PHYSIOL, V81, P139, DOI 10.1146/annurev-physiol-020518-114455
   Neishabouri SH, 2015, AMINO ACIDS, V47, P1167, DOI 10.1007/s00726-015-1944-y
   Ong SB, 2010, CIRCULATION, V121, P2012, DOI 10.1161/CIRCULATIONAHA.109.906610
   Onishi M, 2021, EMBO J, V40, DOI 10.15252/embj.2020104705
   Paolisso P, 2022, CARDIOVASC DIABETOL, V21, DOI 10.1186/s12933-022-01506-8
   Patorno E, 2019, CIRCULATION, V139, P2822, DOI 10.1161/CIRCULATIONAHA.118.039177
   Philippaert K, 2021, CIRCULATION, V143, P2188, DOI 10.1161/CIRCULATIONAHA.121.053350
   Pietschner R, 2021, CARDIOVASC DIABETOL, V20, DOI 10.1186/s12933-021-01410-7
   Quagliariello V, 2021, CARDIOVASC DIABETOL, V20, DOI 10.1186/s12933-021-01346-y
   Radlinger B, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-76698-8
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   Reis K, 2009, FEBS LETT, V583, P1391, DOI 10.1016/j.febslet.2009.04.015
   Riley JS, 2020, EMBO REP, V21, DOI 10.15252/embr.201949799
   Rodríguez-Nuevo A, 2018, EMBO J, V37, DOI 10.15252/embj.201796553
   Rötig A, 2003, J AM SOC NEPHROL, V14, P2995, DOI 10.1097/01.ASN.0000095481.24091.C9
   Ruiz-Canela M, 2016, CLIN CHEM, V62, P582, DOI 10.1373/clinchem.2015.251710
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sansbury BE, 2014, CIRC-HEART FAIL, V7, P634, DOI 10.1161/CIRCHEARTFAILURE.114.001151
   Santos-Gallego CG, 2021, J AM COLL CARDIOL, V77, P243, DOI 10.1016/j.jacc.2020.11.008
   Santos-Gallego CG, 2019, J AM COLL CARDIOL, V73, P1931, DOI 10.1016/j.jacc.2019.01.056
   Shao QM, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0964-4
   Song Y, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23010437
   Sun HP, 2016, CIRCULATION, V133, P2038, DOI 10.1161/CIRCULATIONAHA.115.020226
   Sun XD, 2020, DIABETES, V69, P1292, DOI 10.2337/db19-0991
   Swift F, 2008, CARDIOVASC RES, V78, P71, DOI 10.1093/cvr/cvn013
   Tan YK, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.758080
   Taylor SI, 2015, J CLIN ENDOCR METAB, V100, P2849, DOI 10.1210/jc.2015-1884
   Tin A, 2016, J AM SOC NEPHROL, V27, P2467, DOI 10.1681/ASN.2015060661
   Toyama T, 2019, DIABETES OBES METAB, V21, P1237, DOI 10.1111/dom.13648
   Trum M, 2020, ESC HEART FAIL, V7, P4429, DOI 10.1002/ehf2.13024
   Uthman L, 2022, BIOMED PHARMACOTHER, V146, DOI 10.1016/j.biopha.2021.112515
   Uthman L, 2019, CARDIOVASC RES, V115, P1533, DOI 10.1093/cvr/cvz004
   Uthman L, 2018, DIABETOLOGIA, V61, P722, DOI 10.1007/s00125-017-4509-7
   Velmurugan S, 2019, CIRC RES, V125
   Verma S, 2018, JACC-BASIC TRANSL SC, V3, P576
   Villa E, 2018, TRENDS CELL BIOL, V28, P882, DOI 10.1016/j.tcb.2018.07.004
   Vitale Rebecca J, 2021, AACE Clin Case Rep, V7, P10, DOI 10.1016/j.aace.2020.11.019
   Wai T, 2016, TRENDS ENDOCRIN MET, V27, P105, DOI 10.1016/j.tem.2015.12.001
   Wan XX, 2016, PLOS PATHOG, V12, DOI 10.1371/journal.ppat.1005954
   Wang CY, 2020, BIOLOGY-BASEL, V9, DOI 10.3390/biology9110369
   Weng SW, 2009, DIABETES RES CLIN PR, V83, P94, DOI 10.1016/j.diabres.2008.10.002
   Wiersma M, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8101202
   Wu HK, 2020, AUTOPHAGY, V16, P683, DOI [10.1080/15548627.2019.1635380, 10.1080/15548627.2019.1596482]
   Wu JX, 2013, SCIENCE, V339, P826, DOI 10.1126/science.1229963
   Wu WX, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0122047
   Xu CK, 2018, BIOCHEM PHARMACOL, V152, P45, DOI 10.1016/j.bcp.2018.03.013
   Xu FX, 2012, DIABETIC MED, V29, pE47, DOI 10.1111/j.1464-5491.2011.03565.x
   Xu L, 2017, EBIOMEDICINE, V20, P137, DOI 10.1016/j.ebiom.2017.05.028
   Xu M, 2019, CARDIOVASC RES, V115, P530, DOI 10.1093/cvr/cvy217
   Yang KC, 2014, FREE RADICAL BIO MED, V71, P351, DOI 10.1016/j.freeradbiomed.2014.03.033
   Yang SY, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0270951
   Yurista SR, 2019, EUR J HEART FAIL, V21, P862, DOI 10.1002/ejhf.1473
   Zhao D, 2020, BMC MED, V18, DOI 10.1186/s12916-020-01715-6
   Zhou H, 2018, REDOX BIOL, V15, P335, DOI 10.1016/j.redox.2017.12.019
   Zinman B, 2016, NEW ENGL J MED, V374, P1094, DOI 10.1056/NEJMc1600827
   Zou RJ, 2022, CARDIOVASC DIABETOL, V21, DOI 10.1186/s12933-022-01532-6
   Zuurbier CJ, 2021, CARDIOVASC RES, V117, P2699, DOI 10.1093/cvr/cvab129
NR 141
TC 0
Z9 0
U1 5
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD JUN
PY 2024
VL 239
IS 6
DI 10.1002/jcp.31264
EA MAY 2024
PG 17
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA UD6I2
UT WOS:001226805200001
PM 38764242
DA 2025-06-11
ER

PT J
AU Carresi, C
   Gliozzi, M
   Musolino, V
   Scicchitano, M
   Scarano, F
   Bosco, F
   Nucera, S
   Maiuolo, J
   Macrì, R
   Ruga, S
   Oppedisano, F
   Zito, MC
   Guarnieri, L
   Mollace, R
   Tavernese, A
   Palma, E
   Bombardelli, E
   Fini, M
   Mollace, V
AF Carresi, Cristina
   Gliozzi, Micaela
   Musolino, Vincenzo
   Scicchitano, Miriam
   Scarano, Federica
   Bosco, Francesca
   Nucera, Saverio
   Maiuolo, Jessica
   Macri, Roberta
   Ruga, Stefano
   Oppedisano, Francesca
   Zito, Maria Caterina
   Guarnieri, Lorenza
   Mollace, Rocco
   Tavernese, Annamaria
   Palma, Ernesto
   Bombardelli, Ezio
   Fini, Massimo
   Mollace, Vincenzo
TI The Effect of Natural Antioxidants in the Development of Metabolic
   Syndrome: Focus on Bergamot Polyphenolic Fraction
SO NUTRIENTS
LA English
DT Review
DE metabolic syndrome; plant extracts; natural antioxidant; polyphenols;
   bergamot
ID DIET-INDUCED OBESITY; FATTY LIVER-DISEASE; INSULIN-RESISTANCE;
   ADIPOSE-TISSUE; TNF-ALPHA; ORAL BIOAVAILABILITY; 3T3-L1 ADIPOCYTES;
   PROTEIN-KINASE; CINNAMIC ACID; CARNOSIC ACID
AB Metabolic syndrome (MetS) represents a set of clinical findings that include visceral adiposity, insulin-resistance, high triglycerides (TG), low high-density lipoprotein cholesterol (HDL-C) levels and hypertension, which is linked to an increased risk of developing type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular disease (ASCVD). The pathogenesis of MetS involves both genetic and acquired factors triggering oxidative stress, cellular dysfunction and systemic inflammation process mainly responsible for the pathophysiological mechanism. In recent years, MetS has gained importance due to the exponential increase in obesity worldwide. However, at present, it remains underdiagnosed and undertreated. The present review will summarize the pathogenesis of MetS and the existing pharmacological therapies currently used and focus attention on the beneficial effects of natural compounds to reduce the risk and progression of MetS. In this regard, emerging evidence suggests a potential protective role of bergamot extracts, in particular bergamot flavonoids, in the management of different features of MetS, due to their pleiotropic anti-oxidative, anti-inflammatory and lipid-lowering effects.
C1 [Carresi, Cristina; Gliozzi, Micaela; Musolino, Vincenzo; Scicchitano, Miriam; Scarano, Federica; Bosco, Francesca; Nucera, Saverio; Maiuolo, Jessica; Macri, Roberta; Ruga, Stefano; Oppedisano, Francesca; Zito, Maria Caterina; Guarnieri, Lorenza; Mollace, Rocco; Tavernese, Annamaria; Palma, Ernesto; Bombardelli, Ezio; Mollace, Vincenzo] Magna Graecia Univ Catanzaro, Inst Res Food Safety & Hlth IRC FSH, I-88100 Catanzaro, Italy.
   [Mollace, Rocco; Tavernese, Annamaria] Univ Roma Tor Vergata, Dept Med, Chair Cardiol, I-00133 Rome, Italy.
   [Palma, Ernesto; Bombardelli, Ezio; Fini, Massimo; Mollace, Vincenzo] Nutramed Scarl, Complesso Nini Barbieri, I-88021 Catanzaro, Italy.
   [Fini, Massimo] IRCCS San Raffaele Pisana, I-00163 Rome, Italy.
C3 Magna Graecia University of Catanzaro; University of Rome Tor Vergata;
   IRCCS San Raffaele Pisana
RP Carresi, C (corresponding author), Magna Graecia Univ Catanzaro, Inst Res Food Safety & Hlth IRC FSH, I-88100 Catanzaro, Italy.
EM carresi@unicz.it; micaela.gliozzi@gmail.com; xabaras3@hotmail.com;
   miriam.scicchitano@hotmail.it; federicascar87@gmail.com;
   boscofrancesca.bf@libero.it; saverio.nucera@hotmail.it;
   jessicamaiuolo@virgilio.it; robertamacri85@gmail.com; rugast1@gmail.com;
   oppedisanof@libero.it; mariacaterina.zito@studenti.unicz.it;
   lorenzacz808@gmail.com; rocco.mollace@gmail.com; an.tavernese@gmail.com;
   palma@unicz.it; ezio.bombardelli@plantexresearch.it;
   massimo.fini@sanraffaele.it; mollace@libero.it
RI MACRI', Roberta/AAC-5967-2022; Bosco, Francesca/HPF-0108-2023; Maiuolo,
   Jessica/AAU-2482-2020; nucera, saverio/AAC-6570-2022; SCARANO,
   FEDERICA/HNC-2414-2023; Gliozzi, Micaela/D-4405-2015; Fini,
   Massimo/AAA-9948-2021; Ruga, Stefano/JUV-6384-2023; Oppedisano,
   Francesca/GRJ-8297-2022; Musolino, Vincenzo/AAC-6429-2022; Mollace,
   Rocco/ABH-5643-2020; carresi, cristina/AAC-6354-2022
OI nucera, saverio/0000-0002-0000-4015; Musolino,
   Vincenzo/0000-0002-4763-2211; Mollace, Rocco/0000-0002-7106-5595; PALMA,
   Ernesto/0000-0003-4199-207X; MACRI', Roberta/0000-0002-2345-6751;
   Oppedisano, Francesca/0000-0003-0930-8987; Guarnieri,
   Lorenza/0009-0007-5865-8779; Ruga, Stefano/0009-0008-0401-4027; SCARANO,
   FEDERICA/0000-0002-9838-9469; tavernese, annamaria/0000-0002-2940-3482;
   Bosco, Francesca/0009-0004-4766-9710; carresi,
   cristina/0000-0002-3509-5930
FU  [PON-MIUR 03PE000_78_1];  [PONMIUR 03PE000_78_2]
FX This work has been supported by PON-MIUR 03PE000_78_1 and PONMIUR
   03PE000_78_2.
CR Affuso F, 2010, WORLD J CARDIOL, V2, P71, DOI 10.4330/wjc.v2.i4.71
   Aggarwal BB, 2010, ANNU REV NUTR, V30, P173, DOI 10.1146/annurev.nutr.012809.104755
   Almeda-Valdes P, 2014, REV RECENT CLIN TRIA, V9, P148, DOI 10.2174/1574887109666141216103908
   Anadón A, 2008, J FOOD PROTECT, V71, P790, DOI 10.4315/0362-028X-71.4.790
   [Anonymous], 2019, ANTIOXIDANTS BASEL
   Barter PJ, 2003, ARTERIOSCL THROM VAS, V23, P160, DOI 10.1161/01.ATV.0000054658.91146.64
   Bickers D, 2005, FOOD CHEM TOXICOL, V43, P799, DOI 10.1016/j.fct.2004.09.013
   Boden G, 2002, EUR J CLIN INVEST, V32, P14, DOI 10.1046/j.1365-2362.32.s3.3.x
   Bustanji Y, 2009, J ENZYM INHIB MED CH, V24, P771, DOI 10.1080/14756360802364377
   Calamini B, 2010, BIOCHEM J, V429, P273, DOI 10.1042/BJ20091857
   Cao CF, 2019, EXP THER MED, V17, P3009, DOI 10.3892/etm.2019.7295
   Cao HP, 2007, ARCH BIOCHEM BIOPHYS, V459, P214, DOI 10.1016/j.abb.2006.12.034
   Capomolla AS, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061271
   Castro-Martinez Maria Guadalupe, 2012, Cir Cir, V80, P128
   Chaiyasit Kamon, 2009, Journal of the Medical Association of Thailand, V92, P108
   Chang TY, 2009, AM J PHYSIOL-ENDOC M, V297, pE1, DOI 10.1152/ajpendo.90926.2008
   Chen YR, 2009, EUR J DRUG METAB PH, V34, P51, DOI 10.1007/BF03191384
   Chistiakov DA, 2017, BIOCHIMIE, V132, P19, DOI 10.1016/j.biochi.2016.10.010
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Czech MP, 2017, NAT MED, V23, P804, DOI 10.1038/nm.4350
   Di Pierro F, 2015, EUR REV MED PHARMACO, V19, P4195
   Djousse L., 2010, Endocrine Metabolic & Immune Disorders-Drug Targets, V10, P124
   Donath MY, 2011, NAT REV IMMUNOL, V11, P98, DOI 10.1038/nri2925
   Doolaege EHA, 2011, PLANT FOOD HUM NUTR, V66, P196, DOI 10.1007/s11130-011-0233-5
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   Fernández-Miranda C, 2008, DIGEST LIVER DIS, V40, P200, DOI 10.1016/j.dld.2007.10.002
   Gardana C, 2008, MOLECULES, V13, P2220, DOI 10.3390/molecules13092220
   Gliozzi M., 2014, Advances in Biological Chemistry, V4, P129, DOI 10.4236/abc.2014.42017
   Gliozzi M, 2013, INT J CARDIOL, V170, P140, DOI 10.1016/j.ijcard.2013.08.125
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Grundy SM, 2005, AM J CARDIOL, V95, P462, DOI 10.1016/j.amjcard.2004.10.012
   Gui SY, 2008, PHARMAZIE, V63, P516, DOI 10.1691/ph.2008.8018
   Gurka MJ, 2018, NUTR DIABETES, V8, DOI 10.1038/s41387-018-0024-2
   Horrillo R, 2010, J IMMUNOL, V184, P3978, DOI 10.4049/jimmunol.0901355
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Jayaprakasha GK, 2011, CRIT REV FOOD SCI, V51, P547, DOI 10.1080/10408391003699550
   Kang JH, 2010, OBESITY, V18, P780, DOI 10.1038/oby.2009.301
   Kelany ME, 2017, CAN J PHYSIOL PHARM, V95, P140, DOI 10.1139/cjpp-2016-0152
   Kopel E, 2014, ANN INTERN MED, V161, P157, DOI [10.7326/L14-5014, 10.7326/M13-1725, 10.7326/L14-5014-2]
   Kumar A, 2015, EUR J PHARMACOL, V761, P288, DOI 10.1016/j.ejphar.2015.05.068
   Lan JR, 2015, J ETHNOPHARMACOL, V161, P69, DOI 10.1016/j.jep.2014.09.049
   Landsberg L, 2013, OBESITY, V21, P8, DOI 10.1002/oby.20181
   Lee E, 2015, FASEB J, V29, P3182, DOI 10.1096/fj.14-268300
   Lee YS, 2006, DIABETES, V55, P2256, DOI 10.2337/db06-0006
   Lin JY, 2019, MED SCI MONITOR, V25, P87, DOI 10.12659/MSM.911849
   Liu Y, 2019, MOL MED REP, V20, P495, DOI 10.3892/mmr.2019.10299
   Ma JY, 2013, J PHARM SCI-US, V102, P4181, DOI 10.1002/jps.23718
   Malur Pavan, 2017, Mo Med, V114, P464
   Matsuzawa Y, 2011, J ATHEROSCLER THROMB, V18, P629, DOI 10.5551/jat.7922
   Medagama AB, 2015, NUTR J, V14, DOI [10.1186/s12937-015-0013-4, 10.1186/s12937-015-0098-9]
   Mollace V, 2008, J CARDIOVASC PHARM T, V13, P120, DOI 10.1177/1074248407313821
   Mollace V, 2019, ENDOCR METAB IMMUNE, V19, P136, DOI 10.2174/1871530319666181203151513
   Mollace V, 2011, FITOTERAPIA, V82, P309, DOI 10.1016/j.fitote.2010.10.014
   Musolino V, 2020, J TRADIT COMPL MED, V10, P268, DOI 10.1016/j.jtcme.2020.02.004
   Musolino V, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-59485-3
   Musolino V, 2019, LIPIDS HEALTH DIS, V18, DOI 10.1186/s12944-019-1061-0
   Naseem Zahra Naseem Zahra, 2016, Pakistan Journal of Food Sciences, V26, P54
   Neeland IJ, 2013, OBESITY, V21, pE439, DOI [10.1002/oby.20135, 10.1038/oby.20135]
   Nikolic D, 2013, NUTRIENTS, V5, P928, DOI 10.3390/nu5030928
   Pan MH, 1999, DRUG METAB DISPOS, V27, P486
   Panchal SK, 2018, NUTRIENTS, V10, DOI 10.3390/nu10050630
   Parafati M, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111604
   Parafati M, 2015, J NUTR BIOCHEM, V26, P938, DOI 10.1016/j.jnutbio.2015.03.008
   Paschos P, 2009, HIPPOKRATIA, V13, P9
   Pekgor S, 2019, METAB SYNDR RELAT D, V17, P296, DOI 10.1089/met.2019.0005
   Peng W, 2015, ACTA PHARMACOL SIN, V36, P139, DOI 10.1038/aps.2014.113
   Pérez-Rubio KG, 2013, METAB SYNDR RELAT D, V11, P366, DOI 10.1089/met.2012.0183
   Potenza MV, 2009, NUTR CLIN PRACT, V24, P560, DOI 10.1177/0884533609342436
   Prasad S, 2014, CANCER RES TREAT, V46, P2, DOI 10.4143/crt.2014.46.1.2
   Pulido-Moran M, 2016, MOLECULES, V21, DOI 10.3390/molecules21030264
   Qiu F, 2008, DRUG METAB DISPOS, V36, P2159, DOI 10.1124/dmd.108.021659
   Quan H, 2006, ANTIMICROB AGENTS CH, V50, P1096, DOI 10.1128/AAC.50.3.1096-1099.2006
   Reaven GM, 2011, J CLIN HYPERTENS, V13, P238, DOI 10.1111/j.1751-7176.2011.00439.x
   Rollyson WD, 2014, J CONTROL RELEASE, V196, P96, DOI 10.1016/j.jconrel.2014.09.027
   Vaquero MR, 2013, MOL NUTR FOOD RES, V57, P1834, DOI 10.1002/mnfr.201300052
   Vaquero MR, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039773
   Rousset X, 2009, CURR OPIN ENDOCRINOL, V16, P163, DOI 10.1097/MED.0b013e328329233b
   Ryu EK, 2006, J MED CHEM, V49, P6111, DOI 10.1021/jm0607193
   Ryu MJ, 2008, BIOCHEM BIOPH RES CO, V377, P1304, DOI 10.1016/j.bbrc.2008.10.171
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Salerno Raffaele, 2016, PharmaNutrition, V4, pS1, DOI 10.1016/j.phanu.2015.10.001
   Samson SL, 2014, ENDOCRIN METAB CLIN, V43, P1, DOI 10.1016/j.ecl.2013.09.009
   Samuel VT, 2016, J CLIN INVEST, V126, P12, DOI 10.1172/JCI77812
   Serhan C.N., 2010, Fundamentals of Inflammation, DOI DOI 10.1017/CBO9781139195737
   Sharma RA, 2004, CLIN CANCER RES, V10, P6847, DOI 10.1158/1078-0432.CCR-04-0744
   Sherling DH, 2017, J CARDIOVASC PHARM T, V22, P365, DOI 10.1177/1074248416686187
   Shin KS, 2013, ARCH PHARM RES, V36, P759, DOI 10.1007/s12272-013-0051-4
   Sirtori CR, 2014, PHARMACOL RES, V88, P3, DOI 10.1016/j.phrs.2014.03.002
   Spigoni V, 2017, NUTRIENTS, V9, DOI 10.3390/nu9121328
   Spite Matthew, 2014, Cell Metab, V19, P21, DOI 10.1016/j.cmet.2013.10.006
   Stratford S, 2004, J BIOL CHEM, V279, P36608, DOI 10.1074/jbc.M406499200
   Subramanian S, 2012, BBA-MOL CELL BIOL L, V1821, P819, DOI 10.1016/j.bbalip.2011.10.003
   Tan SR, 2014, J AGR FOOD CHEM, V62, P1866, DOI 10.1021/jf4040628
   Tan XS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0077969
   Tang YC, 2009, ENDOCRINOLOGY, V150, P3011, DOI 10.1210/en.2008-1601
   Tong NN, 2012, ONCOL LETT, V3, P1263, DOI 10.3892/ol.2012.644
   Vergès B, 2006, CURR OPIN LIPIDOL, V17, P653, DOI 10.1097/01.mol.0000252612.21602.e3
   WAHLSTROM B, 1978, ACTA PHARMACOL TOX, V43, P86
   Wang SL, 2009, BIOMED ENVIRON SCI, V22, P32, DOI 10.1016/S0895-3988(09)60019-2
   Wang T, 2011, EUR J PHARM SCI, V44, P127, DOI 10.1016/j.ejps.2011.06.015
   Wei W, 2012, EUR J ENDOCRINOL, V166, P99, DOI 10.1530/EJE-11-0616
   Weisberg SP, 2008, ENDOCRINOLOGY, V149, P3549, DOI 10.1210/en.2008-0262
   Welty FK, 2016, TRANSL RES, V167, P257, DOI 10.1016/j.trsl.2015.06.017
   Woo HM, 2007, LIFE SCI, V80, P926, DOI 10.1016/j.lfs.2006.11.030
   Wu H, 2017, NAT MED, V23, P850, DOI 10.1038/nm.4345
   Xu JY, 2003, AM J PHYSIOL-GASTR L, V285, pG20, DOI 10.1152/ajpgi.00474.2002
   Yamaoka K, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-138
   Yang Jing, 2012, Evid Based Complement Alternat Med, V2012, P363845, DOI 10.1155/2012/363845
   Yang KY, 2007, J CHROMATOGR B, V853, P183, DOI 10.1016/j.jchromb.2007.03.010
   Yang YS, 2014, PHYTOTHER RES, V28, P1770, DOI 10.1002/ptr.5197
   Zhang CH, 2014, J ETHNOPHARMACOL, V151, P864, DOI 10.1016/j.jep.2013.11.054
   Zhang J, 2008, J BIOL CHEM, V283, P35375, DOI 10.1074/jbc.M806480200
   Zhang SQ, 2017, J AGR FOOD CHEM, V65, P2323, DOI 10.1021/acs.jafc.7b00132
   Zhang Y, 2013, INT J BIOL MACROMOL, V59, P363, DOI 10.1016/j.ijbiomac.2013.04.074
   Zhao H, 2014, J PHARMACEUT BIOMED, V89, P150, DOI 10.1016/j.jpba.2013.10.044
   Zhao YT, 2015, J AGR FOOD CHEM, V63, P4843, DOI 10.1021/acs.jafc.5b01246
   Zhu RY, 2017, PHARMACOL RES, V122, P78, DOI 10.1016/j.phrs.2017.05.019
   Zhu Y, 2015, ARCH PHARM RES, V38, P512, DOI 10.1007/s12272-014-0481-7
   Ziegenfuss TN, 2006, J INT SOC SPORT NUTR, V3, DOI 10.1186/1550-2783-3-2-45
NR 120
TC 48
Z9 49
U1 0
U2 27
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2020
VL 12
IS 5
AR 1504
DI 10.3390/nu12051504
PG 24
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MB0AV
UT WOS:000542272700157
PM 32455840
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pei, LG
   Yuan, C
   Guo, YT
   Kou, H
   Xia, LP
   Zhang, L
   Yan, YE
   Xu, D
   Wang, H
AF Pei, Lin-guo
   Yuan, Chao
   Guo, Yi-tian
   Kou, Hao
   Xia, Li-ping
   Zhang, Li
   Yan, You-e
   Xu, Dan
   Wang, Hui
TI Prenatal caffeine exposure induced high susceptibility to metabolic
   syndrome in adult female offspring rats and its underlying mechanisms
SO REPRODUCTIVE TOXICOLOGY
LA English
DT Article
DE Prenatal caffeine exposure; Metabolic syndrome; Catch-up growth; Insulin
   resistance
ID CORONARY-HEART-DISEASE; FATTY LIVER-DISEASE; CHOLESTEROL RATIO;
   STEROIDOGENIC FACTOR-1; PROGRAMMING ALTERATION; INSULIN-RESISTANCE;
   EARLY NUTRITION; FETAL; GROWTH; MODEL
AB Our previous studies have demonstrated that prenatal caffeine exposure (PCE) induced an intrauterine programming of hypothalamic-pituitary-adrenal axis (HPAA)-associated neuroendocrine metabolism in 3-month-old offspring rats. In this study, we aimed to confirm this programming disorder and high susceptibility to metabolic syndrome (MS) in 10-month-old female PCE offspring with postnatal catch-up growth. We found that PCE female offspring rats showed decreased bodyweight but a higher rate of weight gain after birth. Moreover, in the offspring, basal hyperinsulinemia and insulin resistance were observed before unpredictable chronic stress (UCS), but serum total cholesterol (TCH) levels and triglyceride/high-density lipoprotein-cholesterol (TG/HDL-C), TCH/HDL-C and low-density lipoprotein-cholesterol/HDL-C (LDL-C/HDL-C) ratio changes were increased after UCS, accompanied by morphological damage of the related tissues. These results suggested that PCE adult female offspring rats were highly susceptible to MS, which is related to HPAA-associated neuroendocrine-metabolic programming disorder. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Pei, Lin-guo; Yuan, Chao; Guo, Yi-tian; Kou, Hao; Xia, Li-ping; Zhang, Li; Yan, You-e; Xu, Dan; Wang, Hui] Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China.
   [Kou, Hao; Xia, Li-ping; Xu, Dan; Wang, Hui] Hubei Prov Key Lab Dev Originated Dis, Wuhan, Peoples R China.
   [Pei, Lin-guo] Nanyang Med Univ, Basic Med Coll, Nanyang 473061, Peoples R China.
C3 Wuhan University
RP Wang, H (corresponding author), Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China.
EM wanghui19@whu.edu.cn
FU National Natural Science Foundation of China [81220108026, 81430089,
   81673524]; Hubei Province Health and Family Planning Scientific Research
   Project [WJ2017C0003]; Young Investigator Program of Zhongnan Hospital
   of Wuhan University [2015A02]
FX This work was supported by grants from the National Natural Science
   Foundation of China (Nos.81220108026, 81430089, 81673524), Hubei
   Province Health and Family Planning Scientific Research Project (No.
   WJ2017C0003), and Young Investigator Program of Zhongnan Hospital of
   Wuhan University (No. 2015A02).
CR Ahmad A, 2012, PHYTOMEDICINE, V19, P639, DOI 10.1016/j.phymed.2012.02.012
   BARKER DJP, 1990, BRIT MED J, V301, P1111, DOI 10.1136/bmj.301.6761.1111
   BARKER DJP, 1993, LANCET, V341, P938, DOI 10.1016/0140-6736(93)91224-A
   Bergman RN, 2007, AM J MED, V120, pS3, DOI 10.1016/j.amjmed.2006.11.012
   Bibeau K, 2010, AM J PHYSIOL-REG I, V298, pR899, DOI 10.1152/ajpregu.00238.2009
   Bittner V, 2009, AM HEART J, V157, P548, DOI 10.1016/j.ahj.2008.11.014
   Boylan S, 2008, BMJ-BRIT MED J, V337, DOI 10.1136/bmj.a2332
   Briana DD, 2009, EUR J ENDOCRINOL, V160, P337, DOI 10.1530/EJE-08-0621
   Bruce KD, 2009, POSTGRAD MED J, V85, P614, DOI 10.1136/pgmj.2008.078014
   Chang LL, 2012, TOXICOLOGY, V301, P40, DOI 10.1016/j.tox.2012.06.017
   Che Y, 2015, NEUROSCI LETT, V584, P208, DOI 10.1016/j.neulet.2014.10.031
   Davis EP, 2011, J CHILD PSYCHOL PSYC, V52, P119, DOI 10.1111/j.1469-7610.2010.02314.x
   Roche LD, 2012, INT J VASC MED, V2012, DOI 10.1155/2012/898769
   Eckel RH, 2010, LANCET, V375, P181, DOI 10.1016/S0140-6736(09)61794-3
   Fagerberg B, 2004, J INTERN MED, V256, P254, DOI 10.1111/j.1365-2796.2004.01361.x
   Fernandez ML, 2008, J AM COLL NUTR, V27, P1, DOI 10.1080/07315724.2008.10719668
   Da Silveira VMF, 2008, REV SAUDE PUBL, V42, P10, DOI 10.1590/S0034-89102008000100002
   García-Cáceres C, 2010, PSYCHONEUROENDOCRINO, V35, P1525, DOI 10.1016/j.psyneuen.2010.05.006
   Guilbert J J, 2003, Educ Health (Abingdon), V16, P230
   Hadaegh F, 2009, NUTR METAB CARDIOVAS, V19, P401, DOI 10.1016/j.numecd.2008.09.003
   Hajer G. R., 2008, EUR HEART J, V29
   HALES CN, 1992, DIABETOLOGIA, V35, P595, DOI 10.1093/ije/dyt133
   Harris A, 2011, HORM BEHAV, V59, P279, DOI 10.1016/j.yhbeh.2010.06.007
   Inoue T, 2009, BIOMED RES-TOKYO, V30, P325, DOI 10.2220/biomedres.30.325
   Jensen RB, 2011, HORM RES PAEDIAT, V75, P2, DOI 10.1159/000315656
   Kluger Jeffrey, 2004, Time, V164, P52
   Langley-Evans SC, 2009, J ANAT, V215, P36, DOI 10.1111/j.1469-7580.2008.00977.x
   Li J, 2015, TOXICOL APPL PHARM, V284, P345, DOI 10.1016/j.taap.2015.03.002
   Lim K, 2011, PEDIATR RES, V70, P339, DOI 10.1203/PDR.0b013e31822a65a3
   Liu YS, 2012, TOXICOL APPL PHARM, V262, P205, DOI 10.1016/j.taap.2012.05.002
   Luo HW, 2014, TOXICOL APPL PHARM, V274, P383, DOI 10.1016/j.taap.2013.11.020
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mierzynski R, 2016, CURR PHARM BIOTECHNO, V17, P587, DOI 10.2174/1389201017666160301104323
   Moisiadis VG, 2014, NAT REV ENDOCRINOL, V10, P403, DOI 10.1038/nrendo.2014.74
   Moisiadis VG, 2014, NAT REV ENDOCRINOL, V10, P391, DOI 10.1038/nrendo.2014.73
   MONTANO MM, 1993, J REPROD FERTIL, V99, P283
   Peck JD, 2010, FOOD CHEM TOXICOL, V48, P2549, DOI 10.1016/j.fct.2010.06.019
   Ping J, 2014, TOXICOLOGY, V321, P53, DOI 10.1016/j.tox.2014.03.011
   Rabe K, 2008, MOL MED, V14, P741, DOI 10.2119/2008-00058.Rabe
   Reagan-Shaw S, 2008, FASEB J, V22, P659, DOI 10.1096/fj.07-9574LSF
   Remacle C, 2007, DIABETES OBES METAB, V9, P196, DOI 10.1111/j.1463-1326.2007.00790.x
   Reynolds RM, 2013, CLIN OBSTET GYNECOL, V56, P602, DOI 10.1097/GRF.0b013e31829939f7
   Scaglione R, 2010, INTERN EMERG MED, V5, P111, DOI 10.1007/s11739-009-0332-6
   Shen L, 2014, TOXICOL APPL PHARM, V274, P263, DOI 10.1016/j.taap.2013.11.009
   SHIM Y, 2017, J ATHEROSCLER THROMB
   Singhal A, 2003, LANCET, V361, P1089, DOI 10.1016/S0140-6736(03)12895-4
   Singhal A, 2002, AM J CLIN NUTR, V75, P993, DOI 10.1093/ajcn/75.6.993
   Singhal A, 2001, LANCET, V357, P413, DOI 10.1016/S0140-6736(00)04004-6
   Thelander G, 2010, CLIN TOXICOL, V48, P354, DOI 10.3109/15563650903586752
   Wang LL, 2014, TOXICOL LETT, V224, P311, DOI 10.1016/j.toxlet.2013.11.006
   Wu YM, 2015, TOXICOL APPL PHARM, V289, P109, DOI 10.1016/j.taap.2015.09.007
   Xn D, 2012, TOXICOL APPL PHARM, V264, P395, DOI 10.1016/j.taap.2012.08.016
   Xu D., 2012, PLOS ONE, V7
   Yan YE, 2014, TOXICOL APPL PHARM, V277, P231, DOI 10.1016/j.taap.2014.03.019
   Zhang L, ARCH MED RES, V44
NR 55
TC 11
Z9 12
U1 0
U2 14
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0890-6238
J9 REPROD TOXICOL
JI Reprod. Toxicol.
PD AUG
PY 2017
VL 71
BP 150
EP 158
DI 10.1016/j.reprotox.2017.06.045
PG 9
WC Reproductive Biology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Reproductive Biology; Toxicology
GA FC3KD
UT WOS:000406736600021
PM 28625926
DA 2025-06-11
ER

PT J
AU Afsar, B
   Elsurer, R
   Sezer, S
   Ozdemir, NF
AF Afsar, Baris
   Elsurer, Rengin
   Sezer, Siren
   Ozdemir, Nurhan F.
TI Does Metabolic Syndrome Have an Impact on the Quality of Life and Mood
   of Hemodialysis Patients?
SO JOURNAL OF RENAL NUTRITION
LA English
DT Article
ID STAGE RENAL-DISEASE; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY;
   HEALTH-STATUS; DEPRESSION; ASSOCIATION; MORTALITY; SYMPTOMS;
   HOSPITALIZATION; MALNUTRITION
AB Objective: Little is known about the association between metabolic syndrome (MetSyn), health-related quality of life (HRQoL), and depressive symptoms in hemodialysis (HD) patients. We hypothesized that MetSyn may be associated with lower HRQoL and depression in HD patients.
   Design: This was a cross-sectional study.
   Setting: The trial involved HID patients at a tertiary-care hospital.
   Patients: We evaluated 115 patients (41 women and 74 men; mean age, 48.4 +/- SD 11.9 years SD).
   Methods: MetSyn was defined according to National Cholesterol Education Panel criteria. The Medical Outcomes Study Short Form-36 (SF-36) and Beck Depression Inventory (BDI) were used to assess HRQoL and signs of depression, respectively. We compared HRQoL and clinical and psychosocial characteristics among participants with and without MetSyn.
   Results: Fifty patients (43.5%) had MetSyn, and 65 patients (56.5%) were free of MetSyn. Comparisons of SF-36 and BDI scores between HID patients with and without MetSyn revealed no statistically significant differences. The Physical Component Summary Score (PCS) of SF-36 was independently associated with HD duration (beta = -0.274, P = .002), age (beta = -0.206, P =.024), sleep disturbance (beta = -0.175, P = .045), albumin (beta = +0.252, P = .006), and hemoglobin (beta = +0.270, P = .002) in stepwise linear regression analysis. The MetSyn was not associated with PCS. The Mental Component Summary Score of SF-36 was independently associated with hemoglobin (beta = +0.235, P = .016) and BDI score (beta = -0.218, P =.025).
   Conclusions: The presence of MetSyn was not associated with HRQoL according to the Mental Component Summary Score. In HID patients, HRQoL and depressive behaviors were not influenced by MetSyn, but by various other factors. (C) 2009 by the National Kidney Foundation, Inc. All rights reserved.
C1 [Afsar, Baris; Elsurer, Rengin; Sezer, Siren; Ozdemir, Nurhan F.] Baskent Univ Hosp, Dept Nephrol, TR-06500 Ankara, Turkey.
C3 Baskent University
RP Afsar, B (corresponding author), Baskent Univ Hosp, Dept Nephrol, 3 Cadde 50 Sokak 9-8, TR-06500 Ankara, Turkey.
EM afsarbrs@yahoo.com
RI sezer, siren/JYQ-2550-2024; Elsurer, Rengin/HJH-6083-2023; Ozdemir Acar,
   Fatma Nurhan/AAK-1697-2021
OI Sezer, Siren/0000-0002-7326-8388; Ozdemir Acar, Fatma
   Nurhan/0000-0002-5682-0943
CR Acaray A, 2005, INT UROL NEPHROL, V37, P595, DOI 10.1007/s11255-005-0397-8
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   Boulware LE, 2006, CLIN J AM SOC NEPHRO, V1, P496, DOI 10.2215/CJN.00030505
   Chiba M, 2000, METABOLISM, V49, P1145, DOI 10.1053/meta.2000.8611
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   DAUGIRDAS JT, 1993, J AM SOC NEPHROL, V4, P1205
   DeOreo PB, 1997, AM J KIDNEY DIS, V30, P204, DOI 10.1016/S0272-6386(97)90053-6
   EVANS RW, 1985, NEW ENGL J MED, V312, P553, DOI 10.1056/NEJM198502283120905
   GUTMAN RA, 1981, NEW ENGL J MED, V304, P309, DOI 10.1056/NEJM198102053040601
   Iliescu EA, 2003, NEPHROL DIAL TRANSPL, V18, P126, DOI 10.1093/ndt/18.1.126
   Johansen KL, 2006, AM J CLIN NUTR, V83, P543, DOI 10.1093/ajcn.83.3.543
   Johansen KL, 2001, KIDNEY INT, V59, P1121, DOI 10.1046/j.1523-1755.2001.00597.x
   Kalantar-Zadeh K, 2001, J AM SOC NEPHROL, V12, P2797, DOI 10.1681/ASN.V12122797
   Kimmel PL, 2000, KIDNEY INT, V57, P2093, DOI 10.1046/j.1523-1755.2000.00059.x
   Kimmel PL, 2005, SEMIN DIALYSIS, V18, P91, DOI 10.1111/j.1525-139X.2005.18209.x
   KIMMEL PL, 1993, J AM SOC NEPHROL, V4, P12
   Kocyigit H., 1999, Glac ve Tedavi Dergisi, V12, P102, DOI DOI 10.28982/JOSAM.368341
   Koo JR, 2003, AM J KIDNEY DIS, V41, P1037, DOI 10.1016/S0272-6386(03)00201-4
   Lawlor DA, 2003, BRIT MED J, V327, P1383, DOI 10.1136/bmj.327.7428.1383
   Moreno F, 2000, J AM SOC NEPHROL, V11, P335, DOI 10.1681/ASN.V112335
   Ohri-Vachaspati P, 1999, J Ren Nutr, V9, P9
   Okamura F, 2000, METABOLISM, V49, P1255, DOI 10.1053/meta.2000.9515
   Rasic-Milutinovic Z, 2007, INTERNAL MED, V46, P945, DOI 10.2169/internalmedicine.46.0092
   Roos C, 2007, METABOLISM, V56, P825, DOI 10.1016/j.metabol.2007.01.013
   Roriz-Cruz M, 2007, J AM GERIATR SOC, V55, P374, DOI 10.1111/j.1532-5415.2007.01068.x
   Savasir I., 1997, Assessment in cognitive behavioral therapies: Commonly used scales
   Schlotz W, 2007, QUAL LIFE RES, V16, P429, DOI 10.1007/s11136-006-9129-5
   Silveira E, 2005, QUAL LIFE RES, V14, P1263, DOI 10.1007/s11136-004-7753-5
   Walters BAJ, 2002, AM J KIDNEY DIS, V40, P1185, DOI 10.1053/ajkd.2002.36879
   WARE JE, 1992, MED CARE, V30, P473, DOI 10.1097/00005650-199206000-00002
   Williams SW, 2002, AM J NEPHROL, V22, P18, DOI 10.1159/000046670
   Young Daniel O, 2007, Hemodial Int, V11, P86
NR 32
TC 7
Z9 8
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1051-2276
EI 1532-8503
J9 J RENAL NUTR
JI J. Renal Nutr.
PD SEP
PY 2009
VL 19
IS 5
BP 365
EP 371
DI 10.1053/j.jrn.2009.01.016
PG 7
WC Nutrition & Dietetics; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Urology & Nephrology
GA 529JC
UT WOS:000272511000003
PM 19464928
DA 2025-06-11
ER

PT J
AU Kim, TE
   Kim, DY
   Kim, H
   Kim, SH
AF Kim, Tae-Eun
   Kim, Do Young
   Kim, Hyeongsu
   Kim, Sung Hea
TI Sex and Age Differences in the Impact of Metabolic Syndrome on Heart
   Failure Development
SO METABOLITES
LA English
DT Review
DE metabolic syndrome; heart failure; sex difference; young age
ID HIGH-DENSITY-LIPOPROTEIN; ISCHEMIA-REPERFUSION INJURY; C-REACTIVE
   PROTEIN; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; PRESSURE-OVERLOAD;
   OXIDATIVE STRESS; YOUNG-ADULTS; FOLLOW-UP; ASSOCIATION
AB Metabolic syndrome (MetS), a cluster of metabolic dysregulations, is recognized as a significant risk factor for the development of heart failure (HF). The pathophysiological mechanisms linking MetS to HF are complex and multifaceted, with the components of MetS contributing to cardiac deterioration through impaired myocardial energy metabolism, increased inflammation, and endothelial dysfunction. Numerous clinical studies have confirmed the relationship between MetS and HF. Multiple studies have demonstrated that the impact of MetS on HF varies by sex and age. Metabolic disorders, including MetS, have a greater impact on HF incidence in younger adults compared to the elderly population and in women compared to men. Although the reasons for these differences are not yet fully understood, recognizing the sex- and age-related variations is crucial for developing targeted strategies to prevent HF in individuals with MetS. Future research should continue to investigate the underlying mechanisms behind these variations and identify optimal management approaches that account for both sex and age in reducing HF risk.
C1 [Kim, Tae-Eun] Konkuk Univ, Med Ctr, Dept Clin Pharmacol, Seoul 05030, South Korea.
   [Kim, Do Young] Ajou Univ Hosp, Ajou Sch Med, Dept Internal Med, Div Cardiol, Suwon 16499, South Korea.
   [Kim, Hyeongsu] Konkuk Univ, Sch Med, Dept Prevent Med, Seoul 05030, South Korea.
   [Kim, Sung Hea] Konkuk Univ, Sch Med, Med Ctr, Dept Internal Med,Div Cardiol, Seoul 05030, South Korea.
C3 Konkuk University; Konkuk University Medical Center; Ajou University;
   Ajou University Hospital; Konkuk University; Konkuk University Medical
   Center; Konkuk University; Konkuk University Medical Center
RP Kim, SH (corresponding author), Konkuk Univ, Sch Med, Med Ctr, Dept Internal Med,Div Cardiol, Seoul 05030, South Korea.
EM shkim@kuh.ac.kr
RI Kim, Jin-Seok/AAK-5424-2020; Kim, Yong Won/AAA-2134-2022
OI Kim, Hyeongsu/0000-0002-5379-134X
FU Konkuk University Medical Center Research [K230114]; Konkuk University
   Medical Center Research Grant
FX This research was funded by the Konkuk University Medical Center
   Research Grant K230114.
CR Aimo A, 2020, EUR J PREV CARDIOL, V27, P494, DOI 10.1177/2047487319870344
   Barasa A, 2014, EUR HEART J, V35, P25, DOI 10.1093/eurheartj/eht278
   Beckles DL, 2006, VASC PHARMACOL, V45, P350, DOI 10.1016/j.vph.2006.05.006
   Benjamin EJ, 2018, CIRCULATION, V137, pE67, DOI [10.1161/CIR.0000000000000485, 10.1161/CIR.0000000000000558, 10.1161/CIR.0000000000000530]
   Bild DE, 2002, AM J EPIDEMIOL, V156, P871, DOI 10.1093/aje/kwf113
   BOWRY VW, 1992, P NATL ACAD SCI USA, V89, P10316, DOI 10.1073/pnas.89.21.10316
   Bozkurt B, 2021, EUR J HEART FAIL, V23, P352, DOI 10.1002/ejhf.2115
   Braunwald E, 2013, JACC-HEART FAIL, V1, P1, DOI 10.1016/j.jchf.2012.10.002
   Brouwers FP, 2013, EUR HEART J, V34, P1424, DOI 10.1093/eurheartj/eht066
   Butler J, 2006, J AM COLL CARDIOL, V47, P1595, DOI 10.1016/j.jacc.2005.12.046
   Carpintero R, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011869
   Christiansen MN, 2017, CIRCULATION, V135, P1214, DOI 10.1161/CIRCULATIONAHA.116.025941
   COCKERILL GW, 1995, ARTERIOSCL THROM VAS, V15, P1987, DOI 10.1161/01.ATV.15.11.1987
   Daugherty SL, 2011, J HYPERTENS, V29, P1005, DOI 10.1097/HJH.0b013e3283449512
   DAWBER TR, 1963, ANN NY ACAD SCI, V107, P539, DOI 10.1111/j.1749-6632.1963.tb13299.x
   de Boer RA, 2018, JAMA CARDIOL, V3, P215, DOI 10.1001/jamacardio.2017.4987
   Dei Cas A, 2015, JACC-HEART FAIL, V3, P136, DOI 10.1016/j.jchf.2014.08.004
   Dunlay SM, 2011, CIRC-CARDIOVASC QUAL, V4, P68, DOI 10.1161/CIRCOUTCOMES.110.957225
   Essop MF, 2007, FEBS J, V274, P5278, DOI 10.1111/j.1742-4658.2007.06051.x
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Gargiulo P, 2020, HEART FAIL REV, V25, P1, DOI 10.1007/s10741-019-09838-6
   Golla MSG, 2024, StatPearls
   Gomaraschi M, 2005, BBA-MOL CELL BIOL L, V1736, P136, DOI 10.1016/j.bbalip.2005.08.003
   Heymans S, 2016, J AM COLL CARDIOL, V68, P2348, DOI 10.1016/j.jacc.2016.09.937
   Huang ZM, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.704446
   InanlooRahatloo K, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0183874
   Ingelsson E, 2006, HEART, V92, P1409, DOI 10.1136/hrt.2006.089011
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jacoby JJ, 2003, P NATL ACAD SCI USA, V100, P12929, DOI 10.1073/pnas.2134694100
   KANNEL WB, 1979, AM J EPIDEMIOL, V110, P281, DOI 10.1093/oxfordjournals.aje.a112813
   Kenchaiah S, 2002, NEW ENGL J MED, V347, P305, DOI 10.1056/NEJMoa020245
   Kim TE, 2024, METABOLITES, V14, DOI 10.3390/metabo14090485
   Kim TE, 2022, EPIDEMIOL HEALTH, V44, DOI 10.4178/epih.e2022078
   Klein SL, 2016, NAT REV IMMUNOL, V16, P626, DOI 10.1038/nri.2016.90
   Kostis JB, 2005, AM J HYPERTENS, V18, P731, DOI 10.1016/j.amjhyper.2004.11.038
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lecoeur E, 2023, EUR HEART J, V44, P383, DOI 10.1093/eurheartj/ehac651
   Levy D, 1996, JAMA-J AM MED ASSOC, V275, P1557, DOI 10.1001/jama.275.20.1557
   Li CY, 2007, J EPIDEMIOL COMMUN H, V61, P67, DOI 10.1136/jech.2006.048173
   Liang XP, 2023, POSTGRAD MED J, V99, P985, DOI 10.1093/postmj/qgad008
   Lieb W, 2009, CIRCULATION, V119, P3085, DOI 10.1161/CIRCULATIONAHA.108.824243
   Lin L, 2015, J CELL MOL MED, V19, P1929, DOI 10.1111/jcmm.12567
   Loyer X, 2007, AM J PHYSIOL-HEART C, V293, pH2650, DOI 10.1152/ajpheart.00883.2007
   MACKNESS MI, 1993, ATHEROSCLEROSIS, V104, P129, DOI 10.1016/0021-9150(93)90183-U
   Matsuzawa Y, 2011, J ATHEROSCLER THROMB, V18, P629, DOI 10.5551/jat.7922
   Miller VM, 2008, PHARMACOL REV, V60, P210, DOI 10.1124/pr.107.08002
   Miura Y, 2010, CIRC J, V74, P2612, DOI 10.1253/circj.CJ-10-0677
   Murphy AJ, 2011, ARTERIOSCL THROM VAS, V31, P1333, DOI 10.1161/ATVBAHA.111.226258
   Navab M, 2000, J LIPID RES, V41, P1481
   Nofer JR, 2001, J BIOL CHEM, V276, P34480, DOI 10.1074/jbc.M103782200
   Obi EN, 2016, J MANAG CARE SPEC PH, V22, P1446, DOI 10.18553/jmcp.2016.22.12.1446
   Oda E, 2008, HYPERTENS RES, V31, P1283, DOI 10.1291/hypres.31.1283
   Ouchi N, 2011, NAT REV IMMUNOL, V11, P85, DOI 10.1038/nri2921
   Pan J, 1999, CIRC RES, V84, P1127, DOI 10.1161/01.RES.84.10.1127
   Park MJ, 2006, J ADOLESCENT HEALTH, V39, P305, DOI 10.1016/j.jadohealth.2006.04.017
   Pekgor S, 2019, METAB SYNDR RELAT D, V17, P296, DOI 10.1089/met.2019.0005
   Perrone-Filardi P, 2015, EUR HEART J, V36, P2630, DOI 10.1093/eurheartj/ehv350
   Perrone-Filardi P, 2015, INT J CARDIOL, V178, P85, DOI 10.1016/j.ijcard.2014.10.094
   Purwowiyoto Sidhi Laksono, 2021, Med Pharm Rep, V94, P15, DOI 10.15386/mpr-1884
   Putnam K, 2012, AM J PHYSIOL-HEART C, V302, pH1219, DOI 10.1152/ajpheart.00796.2011
   Sattar N, 2003, CIRCULATION, V108, P414, DOI 10.1161/01.CIR.0000080897.52664.94
   Savarese G, 2022, CARDIOVASC RES, V118, P3272, DOI 10.1093/cvr/cvac013
   Savji N, 2018, JACC-HEART FAIL, V6, P701, DOI 10.1016/j.jchf.2018.05.018
   Seetharam D, 2006, CIRC RES, V98, P63, DOI 10.1161/01.RES.0000199272.59432.5b
   Stirone C, 2005, MOL PHARMACOL, V68, P959, DOI 10.1124/mol.105.014662
   Stratmann B, 2011, DIABETES CARE, V34, pS138, DOI 10.2337/dc11-s208
   Sumner AD, 2012, J CLIN HYPERTENS, V14, P502, DOI 10.1111/j.1751-7176.2012.00647.x
   Suthahar N, 2018, EUR J HEART FAIL, V20, P1205, DOI 10.1002/ejhf.1209
   Tamariz L, 2009, CLIN CARDIOL, V32, P327, DOI 10.1002/clc.20496
   Tromp J, 2021, BMJ-BRIT MED J, V372, DOI 10.1136/bmj.n461
   Wadham C, 2004, CIRCULATION, V109, P2116, DOI 10.1161/01.CIR.0000127419.45975.26
   Wang JJ, 2010, ATHEROSCLEROSIS, V210, P237, DOI 10.1016/j.atherosclerosis.2009.10.042
   Zhai PY, 2000, AM J PHYSIOL-HEART C, V278, pH1640, DOI 10.1152/ajpheart.2000.278.5.H1640
   Zhai PY, 2000, AM J PHYSIOL-HEART C, V279, pH2766, DOI 10.1152/ajpheart.2000.279.6.H2766
NR 74
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD DEC
PY 2024
VL 14
IS 12
AR 653
DI 10.3390/metabo14120653
PG 11
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA Q5A6T
UT WOS:001384810900001
PM 39728435
OA gold
DA 2025-06-11
ER

PT J
AU Martins, CC
   Bagatini, MD
   Cardoso, AM
   Zanini, D
   Abdalla, FH
   Baldissarelli, J
   Dalenogare, DP
   dos Santos, DL
   Schetinger, MRC
   Morsch, VMM
AF Martins, C. C.
   Bagatini, M. D.
   Cardoso, A. M.
   Zanini, D.
   Abdalla, F. H.
   Baldissarelli, J.
   Dalenogare, D. P.
   dos Santos, D. L.
   Schetinger, M. R. C.
   Morsch, V. M. M.
TI Exercise Training positively modulates the Ectonucleotidase Enzymes in
   Lymphocytes of Metabolic Syndrome Patients
SO INTERNATIONAL JOURNAL OF SPORTS MEDICINE
LA English
DT Article
DE metabolic syndrome; E-NTPDase; ADA; exercise training; inflammation
ID ADENOSINE-DEAMINASE ACTIVITIES; NTPDASE; SERUM; INFLAMMATION;
   ACTIVATION; PLATELETS; STRESS; CD39
AB In this study, we investigated the cardiovascular risk factors as well as ectonucleotidase activities in lymphocytes of metabolic syndrome (MetS) patients before and after an exercise intervention. 20 MetS patients, who performed regular concurrent exercise training for 30 weeks, 3 times/week, were studied. Anthropometric, biochemical, inflammatory and hepatic parameters and hydrolysis of adenine nucleotides and nucleoside in lymphocytes were collected from patients before and after 15 and 30 weeks of the exercise intervention as well as from participants of the control group. An increase in the hydrolysis of ATP and ADP, and a decrease in adenosine deamination in lymphocytes of MetS patients before the exercise intervention were observed (P<0.001). However, these alterations were reversed by exercise training after 30 weeks of intervention. Additionally, exercise training reduced the inflammatory and hepatic markers to baseline levels after 30 weeks of exercise. Our results clearly indicated alteration in ectonucleotidase enzymes in lymphocytes in the MetS, whereas regular exercise training had a protective effect on the enzymatic alterations and on inflammatory and hepatic parameters, especially if it is performed regularly and for a long period.
C1 [Martins, C. C.; Cardoso, A. M.; Zanini, D.; Abdalla, F. H.; Baldissarelli, J.; Dalenogare, D. P.; dos Santos, D. L.; Schetinger, M. R. C.; Morsch, V. M. M.] Univ Fed Santa Maria, Dept Bioquim & Biol Mol, Santa Maria, RS, Brazil.
   [Bagatini, M. D.; Cardoso, A. M.] Univ Fed Fronteira Sul, Coordenacao Acad, SC 484,Km 02, BR-89812000 Chapeco, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal da
   Fronteira Sul
RP Bagatini, MD (corresponding author), Univ Fed Fronteira Sul, Coordenacao Acad, SC 484,Km 02, BR-89812000 Chapeco, Brazil.
EM margaretebagatini@yahoo.com.br
RI Schetinger, Maria/JAC-4640-2023; Morsch, Vera/M-6215-2014; dos Santos,
   Daniela/AAU-2310-2021; Cardoso, Andréia/ABH-9732-2020; Padilha
   Dalenogare, Diéssica/IUM-5367-2023; Zanini, Daniela/KEH-7499-2024;
   Bagatini, Margarete/K-3756-2016; Baldissarelli, Jucimara/U-4563-2017
OI Bagatini, Margarete/0000-0001-9263-4980; Cardoso,
   Andreia/0000-0003-4243-8855; Baldissarelli,
   Jucimara/0000-0002-1114-0063; Chitolina Schetinger, Maria
   Rosa/0000-0002-5240-8935; Santos, Daniela/0000-0002-1782-1337; Morsch,
   Vera Maria/0000-0002-5381-4556
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
   [304641/2013-8]; Fundacao de Amparo a Pesquisa do Rio Grande do Sul
   (FAPERGS) [1279-2551/13-7]; Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior (CAPES); FINEP research grant "Rede Instituto Brasileiro
   de Neurociencia (IBN-Net)"; "Instituto Nacional de Ciencia e Tecnologia"
   (INCT)
FX The authors wish to thank the Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq) under Grant number 304641/2013-8,
   Fundacao de Amparo a Pesquisa do Rio Grande do Sul (FAPERGS) under Grant
   number 1279-2551/13-7, Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior (CAPES), the FINEP research grant "Rede Instituto
   Brasileiro de Neurociencia (IBN-Net)" and "Instituto Nacional de Ciencia
   e Tecnologia" (INCT) for their financial support of this work.
CR [Anonymous], 2005, ARQ BRAS CARDIOL, DOI DOI 10.1590/S0066-782X2005000100001
   [Anonymous], ANAL BIOCH
   BOYUM A, 1968, SCAND J CLIN LAB INV, VS 21, P77
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Brzycki M., 1993, JOPERD, V64, P88, DOI [10.1080/07303084.1993.10606684, DOI 10.1080/07303084.1993.10606684]
   Cardinot TM, 2016, LIFE SCI, V153, P163, DOI 10.1016/j.lfs.2016.04.007
   Cardoso AM, 2015, J HYPERTENS, V33, P763, DOI 10.1097/HJH.0000000000000468
   Cardoso AM, 2012, MOL CELL BIOCHEM, V371, P147, DOI 10.1007/s11010-012-1431-7
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Dorneles G.P., 2016, OBES MED, V2, P25, DOI [DOI 10.1016/J.OBMED.2016.05, DOI 10.1016/J.0BMED.2016.05.004, 10.1016/j.obmed.2016.05]
   GIUSTI G, 1971, ENZYME, V12, P417, DOI 10.1159/000459567
   Han TS., 2015, Medicine, V43, P80, DOI DOI 10.1016/J.MPMED.2014.11.006
   Harriss DJ, 2015, INT J SPORTS MED, V36, P1121, DOI 10.1055/s-0035-1565186
   Ip BC, 2015, TRENDS ENDOCRIN MET, V26, P91, DOI 10.1016/j.tem.2014.12.001
   Kay SJ, 2006, OBES REV, V7, P183, DOI 10.1111/j.1467-789X.2006.00250.x
   KAYYALI US, 1991, J ANAL TOXICOL, V15, P86, DOI 10.1093/jat/15.2.86
   Leal DBR, 2005, BBA-MOL CELL RES, V1746, P129, DOI 10.1016/j.bbamcr.2005.10.009
   Leal DBR, 2005, BBA-GEN SUBJECTS, V1721, P9, DOI 10.1016/j.bbagen.2004.09.006
   Li HB, 2014, CYTOKINE GROWTH F R, V25, P699, DOI 10.1016/j.cytogfr.2014.07.020
   Martins CC, 2016, CLIN CHIM ACTA, V454, P66, DOI 10.1016/j.cca.2015.12.024
   Maury E, 2010, MOL CELL ENDOCRINOL, V314, P1, DOI 10.1016/j.mce.2009.07.031
   Metcalf J.A., 1986, LAB MANUAL NEUTROPHI
   Ohgo H, 2009, DIABETES METAB SYND, V3, P3, DOI 10.1016/j.dsx.2008.10.001
   Peeri M, 2015, MED HYPOTHESES, V85, P707, DOI 10.1016/j.mehy.2015.10.026
   Polachini CRN, 2014, NEUROSCIENCE, V266, P266, DOI 10.1016/j.neuroscience.2014.01.048
   Bono MR, 2015, FEBS LETT, V589, P3454, DOI 10.1016/j.febslet.2015.07.027
   Schetinger MRC, 2007, BIOFACTORS, V31, P77, DOI 10.1002/biof.5520310205
   Shephard RJ, 1999, CIRCULATION, V99, P963, DOI 10.1161/01.CIR.99.7.963
   Siqueira IR, 2010, BRAIN RES, V1316, P173, DOI 10.1016/j.brainres.2009.11.076
   Spanevello RM, 2010, CLIN CHIM ACTA, V411, P210, DOI 10.1016/j.cca.2009.11.005
   Sparks DL, 2012, CELL PHYSIOL BIOCHEM, V30, P1333, DOI 10.1159/000343322
   Takahashi M, 2015, INT J CARDIOL, V201, P142, DOI 10.1016/j.ijcard.2015.08.022
   Thomé GR, 2012, BIOMED PHARMACOTHER, V66, P206, DOI 10.1016/j.biopha.2011.09.014
   Wang CH, 2014, GERIATR NURS, V35, P212, DOI 10.1016/j.gerinurse.2014.02.001
   Welty FK, 2016, TRANSL RES, V167, P257, DOI 10.1016/j.trsl.2015.06.017
   Yamada J, 2006, ATHEROSCLEROSIS, V189, P198, DOI 10.1016/j.atherosclerosis.2005.11.036
NR 36
TC 8
Z9 9
U1 0
U2 4
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0172-4622
EI 1439-3964
J9 INT J SPORTS MED
JI Int. J. Sports Med.
PD NOV
PY 2016
VL 37
IS 12
BP 930
EP 936
DI 10.1055/s-0042-114218
PG 7
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA EC1RL
UT WOS:000387884900002
PM 27626502
DA 2025-06-11
ER

PT J
AU Yang, WQ
   Wang, XH
   Kang, CY
   Yang, LY
   Liu, D
   Zhao, N
   Zhang, XY
AF Yang, Wanqiu
   Wang, Xiaohong
   Kang, Chuanyi
   Yang, Liying
   Liu, Di
   Zhao, Na
   Zhang, Xiangyang
TI Establishment of a risk prediction model for suicide attempts in
   first-episode and drug naive patients with major depressive disorder
SO ASIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Major depression; Suicide attempts; Nomogram; Risk factor
ID NATIONAL-HEALTH; METABOLIC SYNDROME; ASSOCIATION; YOUNG; CHOLESTEROL;
   PREVALENCE; BEHAVIOR; SCALE; DISTURBANCES; THYROTROPIN
AB Background: Suicide is common in patients with major depressive disorder (MDD) and has serious consequences for individuals and families. This study aims to establish a risk prediction model for suicide attempts in MDD patients to make the detection of suicide risk more accurate and effective.
   Methods: A cross-sectional survey, clinical examination, and biochemical indicator tests were performed on 1718 first-episode and drug nai <spacing diaeresis>ve patients with major depressive disorder. We used Machine Learning to establish a risk prediction model for suicide attempts in FEDN patients with MDD.
   Results: Five predictors were identified by LASSO regression analysis from a total of 20 variables studied, namely psychotic symptoms, anxiety symptoms, thyroid peroxidase antibodies (ATPO), total cholesterol (TC), and highdensity lipoprotein-cholesterol (HDL-C). The model constructed using the five predictors displayed moderate predictive ability, with an area under the ROC of 0.771 in the training set and 0.720 in the validation set. The DCA curve showed that the nomogram could be applied clinically if the risk threshold was between 22 % and 60 %. The risk threshold was found to be between 20 % and 60 % in external validation.
   Conclusion: Introducing psychotic symptoms, anxiety symptoms, ATPO, TC, and HDL-C to the risk nomogram increased its usefulness for predicting suicide risk in patients with MDD. It may be useful in clinical decisionmaking or in discussions with patients, especially in crisis interventions.
C1 [Yang, Wanqiu] Yunnan Univ, Sch Ethnol & Sociol, Kunming, Yunnan, Peoples R China.
   [Yang, Wanqiu] Yunnan Univ, Sch Med, Kunming, Yunnan, Peoples R China.
   [Wang, Xiaohong; Kang, Chuanyi; Zhao, Na] Harbin Med Univ, Affiliated Hosp 1, Dept Psychiat, Harbin, Peoples R China.
   [Yang, Liying] Dalian Mental Hlth Ctr, Dalian Peoples Hosp 7, Dalian, Peoples R China.
   [Liu, Di] Harbin Med Univ, Sch Marxism, Harbin, Peoples R China.
   [Zhang, Xiangyang] Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China.
   [Zhang, Xiangyang] Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China.
C3 Yunnan University; Yunnan University; Harbin Medical University; Harbin
   Medical University; Chinese Academy of Sciences; Institute of
   Psychology, CAS; Chinese Academy of Sciences; University of Chinese
   Academy of Sciences, CAS
RP Zhao, N (corresponding author), Harbin Med Univ, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China.; Zhang, XY (corresponding author), 16 Lincui Rd, Beijing 100101, Peoples R China.
EM zhaona@hrbmu.edu.cn; zhangxy@psych.ac.cn
RI Zhang, Xiangyang/ABC-7380-2022; wang, wangxiaohong/IXN-2340-2023
OI Zhang, Xiangyang/0000-0003-3326-382X; LIU, DI/0000-0001-9268-4099
FU Double First Class University Plan; Yunnan University; National Key R
   amp; D Program of China [2017YFE0103700]; First Affiliated Hospital of
   Harbin Medical University [2021B22]
FX We are grateful to all the patients, physicians, and research staff that
   participated in our current study. This study was supported in part by
   grants from the Double First Class University Plan, the " China Rural
   Social Surve " of Yunnan University, the National Key R & amp; D Program
   of China (2017YFE0103700) , and the First Affiliated Hospital of Harbin
   Medical University (2021B22) .
CR Asellus P, 2018, J AFFECT DISORDERS, V225, P246, DOI 10.1016/j.jad.2017.08.019
   Baek JH, 2014, PROG NEURO-PSYCHOPH, V51, P113, DOI 10.1016/j.pnpbp.2014.01.018
   Bartoli F, 2017, CLIN BIOCHEM, V50, P274, DOI 10.1016/j.clinbiochem.2016.11.035
   Berlin I, 1999, INT J NEUROPSYCHOP, V2, P105, DOI 10.1017/S146114579900139X
   Calderón-Garcidueñas L, 2018, ENVIRON RES, V164, P475, DOI 10.1016/j.envres.2018.03.023
   Caspani G, 2021, COMMUN BIOL, V4, DOI 10.1038/s42003-021-02421-6
   Chang JC, 2013, PSYCHOSOM MED, V75, P807, DOI 10.1097/PSY.0000000000000014
   Collins GS, 2015, J CLIN EPIDEMIOL, V68, P112, DOI [10.1016/j.jclinepi.2014.11.010, 10.1002/bjs.9736, 10.7326/M14-0697, 10.1016/j.eururo.2014.11.025, 10.7326/M14-0698, 10.1111/eci.12376, 10.1038/bjc.2014.639, 10.1186/s12916-014-0241-z, 10.1136/bmj.g7594]
   Dimény E, 2021, ORVOSI HETILAP, V162, P1732, DOI 10.1556/650.2021.32225
   Dong M, 2018, J AFFECT DISORDERS, V225, P32, DOI 10.1016/j.jad.2017.07.043
   Dong R, 2021, J AFFECT DISORDERS, V292, P559, DOI 10.1016/j.jad.2021.05.110
   Douglas J, 2019, ANN CLIN PSYCHIATRY, V31, P209
   Duval F., 2022, BRAIN SCI, V12, P621, DOI DOI 10.3390/BRAINSCI12050621
   Duval F, 2021, PSYCHONEUROENDOCRINO, V128, DOI 10.1016/j.psyneuen.2021.105219
   Duval F, 2017, PSYCHONEUROENDOCRINO, V85, P100, DOI 10.1016/j.psyneuen.2017.07.488
   Fan XX, 2020, BMC PSYCHIATRY, V20, DOI 10.1186/s12888-020-02763-1
   Ferlov-Schwensen C, 2017, THYROID, V27, P1475, DOI 10.1089/thy.2017.0365
   Fredriksen KJ, 2022, J CLIN PSYCHIAT, V83, DOI 10.4088/JCP.21m14018
   Gournellis R, 2018, ACTA PSYCHIAT SCAND, V137, P18, DOI 10.1111/acps.12826
   Gyedu A, 2020, INT J GYNECOL OBSTET, V148, P205, DOI 10.1002/ijgo.13019
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   HAMILTON M, 1959, BRIT J MED PSYCHOL, V32, P50, DOI 10.1111/j.2044-8341.1959.tb00467.x
   Harmer B., 2022, StatPearls
   Hawton K, 2013, J AFFECT DISORDERS, V147, P17, DOI 10.1016/j.jad.2013.01.004
   Holma KM, 2010, AM J PSYCHIAT, V167, P801, DOI 10.1176/appi.ajp.2010.09050627
   Hu JL, 2023, ASIAN J PSYCHIATR, V82, DOI 10.1016/j.ajp.2023.103511
   Jeon HJ, 2016, PSYCHIAT INVEST, V13, P609, DOI 10.4306/pi.2016.13.6.609
   Jointer TE, 2003, BEHAV RES THER, V41, P1469, DOI 10.1016/S0005-7967(03)00070-6
   Jones BDM, 2021, LIFE-BASEL, V11, DOI 10.3390/life11080819
   KAY SR, 1987, SCHIZOPHRENIA BULL, V13, P261, DOI 10.1093/schbul/13.2.261
   Kim SM, 2014, PSYCHIAT INVEST, V11, P325, DOI 10.4306/pi.2014.11.3.325
   KORNER A, 1987, ACTA PSYCHIAT SCAND, V76, P355, DOI 10.1111/j.1600-0447.1987.tb05618.x
   Kulak-Bejda A, 2021, J CLIN MED, V10, DOI 10.3390/jcm10020333
   Lätti S, 2016, J CHEMINFORMATICS, V8, DOI 10.1186/s13321-016-0158-y
   Li HH, 2020, J AFFECT DISORDERS, V270, P108, DOI 10.1016/j.jad.2020.03.093
   Li W, 2018, EBIOMEDICINE, V35, P307, DOI 10.1016/j.ebiom.2018.08.009
   Lin CH, 2014, PSYCHIAT RES, V220, P855, DOI 10.1016/j.psychres.2014.08.048
   Liu WT, 2022, BOSNIAN J BASIC MED, V22, P635, DOI 10.17305/bjbms.2021.6754
   Ma YJ, 2019, BMC PSYCHIATRY, V19, DOI 10.1186/s12888-019-2131-6
   Mann JJ, 1999, AM J PSYCHIAT, V156, P181
   Nelson JC, 2018, AM J PSYCHIAT, V175, P897, DOI 10.1176/appi.ajp.2018.17101138
   Nuguru SP, 2022, CUREUS J MED SCIENCE, V14, DOI 10.7759/cureus.28201
   Oh J, 2017, J AFFECT DISORDERS, V213, P51, DOI 10.1016/j.jad.2017.02.002
   Popovic D, 2015, BIPOLAR DISORD, V17, P795, DOI 10.1111/bdi.12338
   Posner K, 2007, AM J PSYCHIAT, V164, P1035, DOI 10.1176/appi.ajp.164.7.1035
   Reisner SL, 2016, LANCET, V388, P412, DOI 10.1016/S0140-6736(16)00684-X
   Roth KB, 2011, J PSYCHIATR RES, V45, P596, DOI 10.1016/j.jpsychires.2010.10.009
   Rui P, 2018, PSYCHIAT RES, V266, P111, DOI 10.1016/j.psychres.2018.05.059
   Sankaranarayanan A, 2021, ACTA PSYCHIAT SCAND, V144, P125, DOI 10.1111/acps.13305
   Segoviano-Mendoza M, 2018, BMC PSYCHIATRY, V18, DOI 10.1186/s12888-018-1596-z
   Shaker NM, 2021, ARCH SUICIDE RES, V25, P641, DOI 10.1080/13811118.2020.1746456
   Shen YM, 2019, J AFFECT DISORDERS, V259, P180, DOI 10.1016/j.jad.2019.08.067
   Sinai C, 2014, EUR J PSYCHOTRAUMATO, V5, DOI 10.3402/ejpt.v5.23911
   Sinclair JMA, 2005, J AFFECT DISORDERS, V87, P107, DOI 10.1016/j.jad.2005.03.001
   So HC, 2021, PSYCHOL MED, V51, P2357, DOI 10.1017/S0033291720000951
   Vickers AJ, 2008, BMC MED INFORM DECIS, V8, DOI 10.1186/1472-6947-8-53
   Vuksan-Cusa Bjanka, 2009, Acta Neuropsychiatr, V21 Suppl 2, P66, DOI 10.1017/S0924270800032798
   Wen X, 2023, ASIAN J PSYCHIATR, V88, DOI 10.1016/j.ajp.2023.103716
   Wenzel A, 2011, J AFFECT DISORDERS, V132, P375, DOI 10.1016/j.jad.2011.03.006
   Ye G, 2022, BMC PSYCHIATRY, V22, DOI 10.1186/s12888-022-04254-x
   Zhang J, 2005, J AFFECT DISORDERS, V89, P25, DOI 10.1016/j.jad.2005.05.021
   Zhao K, 2020, BMC PSYCHIATRY, V20, DOI 10.1186/s12888-020-02791-x
   Zhou YJ, 2021, TRANSL PSYCHIAT, V11, DOI 10.1038/s41398-021-01234-9
NR 63
TC 7
Z9 7
U1 2
U2 13
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1876-2018
EI 1876-2026
J9 ASIAN J PSYCHIATR
JI Asian J. Psychiatr.
PD OCT
PY 2023
VL 88
AR 103732
DI 10.1016/j.ajp.2023.103732
EA AUG 2023
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA R1WQ5
UT WOS:001062317800001
PM 37586124
DA 2025-06-11
ER

PT J
AU Mayneris-Perxachs, J
   Alcaide-Hidalgo, JM
   de la Hera, E
   del Bas, JM
   Arola, L
   Caimari, A
AF Mayneris-Perxachs, Jordi
   Maria Alcaide-Hidalgo, Juan
   de la Hera, Esther
   Maria del Bas, Josep
   Arola, Lluis
   Caimari, Antoni
TI Supplementation with biscuits enriched with hesperidin and naringenin is
   associated with an improvement of the Metabolic Syndrome induced by a
   cafeteria diet in rats
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Metabolic Syndrome; Cafeteria diet; Polyphenols; Citrus flavanones;
   Hesperidin; Naringenin
ID INSULIN-RESISTANCE; HIGH-FAT; GLUCOSYL HESPERIDIN; CHOLESTEROL; OBESITY;
   HYPERTENSION; POLYPHENOLS; PLASMA; LIVER; MECHANISMS
AB Metabolic syndrome (MetS) has become a major public health concern. Because of their numerous health promoting biological properties, polyphenols are potential candidates to ameliorate MetS and, recently, the incorporation of these compounds into widely consumed foodstuffs has emerged as a potential strategy to enhance their intake. Therefore, we aimed to assess the potential beneficial effects of biscuits enriched with the citrus polyphenols hesperidin and naringenin (HN) in rats that were fed either standard chow (STD) or an obesogenic cafeteria diet (CAF) for 16 weeks. The STD and CAF groups were supplemented with either control or FIN biscuits for the final 8 weeks of the study. CAF-fed rats developed MetS, characterized by obesity, insulin resistance, hypertension and dyslipidemia. FIN supplementation in CAF-fed rats ameliorated hypertension and insulin resistance and significantly reduced body weight, mesenteric adiposity, total cholesterol, LDL-C and oxidative stress. Hence, HN biscuits may be a promising functional food against MetS.
C1 [Mayneris-Perxachs, Jordi; Arola, Lluis; Caimari, Antoni] Joint Unit Univ Rovira & Virgili EURECAT, Ctr Tecnol Catalunya, Ctr Omic Sci, Unique Sci & Tech Infrastruct, Reus, Spain.
   [Mayneris-Perxachs, Jordi; Maria Alcaide-Hidalgo, Juan; Maria del Bas, Josep; Arola, Lluis; Caimari, Antoni] Eurecat, Ctr Tecnol Catalunya, Technol Unit Nutr & Hlth, Reus, Spain.
   [Arola, Lluis] Univ Rovira & Virgili, Nutrigen Res Grp, Dept Biochem & Biotechnol, Campus Sescelades, Tarragona, Spain.
   [de la Hera, Esther] IMASDEA, Ctr Res & Dev, El Espinar Segovia, Spain.
   [Mayneris-Perxachs, Jordi] Girona Biomed Res Inst IdIBGi, Nutr Eumetab & Hlth Grp, Girona, Spain.
C3 Universitat Rovira i Virgili; Universitat de Girona; Girona University
   Hospital Dr. Josep Trueta; Institut d'Investigacio Biomedica de Girona
   (IDIBGI)
RP Arola, L (corresponding author), Eurecat, Ctr Tecnol Catalunya, Biotechnol Area, Avinguda Univ 1, Reus 43204, Spain.
EM jmayneris@idibgi.org; juanmaria.alcaide@eurecat.org;
   Esther.delaHera@imasdea.org; josep.delbas@eurecat.org;
   lluis.arola@ce.eurecat.org; antoni.caimari@eurecat.org
RI del Bas, Josep/K-9310-2019; Mayneris-Perxachs, Jordi/AAG-7724-2020;
   Arola, Lluis/C-6074-2011; MAYNERIS-PERXACHS, JORDI/B-2589-2018
OI Arola, Lluis/0000-0003-2767-1974; MAYNERIS-PERXACHS,
   JORDI/0000-0003-3788-3815; Caimari, Antoni/0000-0001-6144-0294; Alcaide
   Hidalgo, Juan Maria/0000-0001-5705-7807; del Bas, Josep
   Maria/0000-0002-0700-2004
FU Agency for Business Competitiveness of the Government of Catalonia
   (ACCIO) [TECCT11-10012]; Center for the Development of Industrial
   Technology (CDTI) of the Spanish Ministry of Economy and Competitiveness
FX This work was supported by the Agency for Business Competitiveness of
   the Government of Catalonia (ACCIO) [TECCT11-10012] and by the Center
   for the Development of Industrial Technology (CDTI) of the Spanish
   Ministry of Economy and Competitiveness [CIEN project SMARTFOODS].
CR Alam MA, 2013, NUTRIENTS, V5, P637, DOI 10.3390/nu5030637
   Amiot MJ, 2016, OBES REV, V17, P573, DOI 10.1111/obr.12409
   Andrade GF, 2013, LIPIDS HEALTH DIS, V12, DOI 10.1186/1476-511X-12-145
   Barreca D, 2017, BIOFACTORS, V43, P495, DOI 10.1002/biof.1363
   Bok SH, 1999, J NUTR, V129, P1182, DOI 10.1093/jn/129.6.1182
   Bok SH, 2000, NUTR RES, V20, P1007, DOI 10.1016/S0271-5317(00)00191-3
   Brown L, 2015, OBES REV, V16, P914, DOI 10.1111/obr.12313
   BUNAG RD, 1973, J APPL PHYSIOL, V34, P279, DOI 10.1152/jappl.1973.34.2.279
   Caimari A, 2017, J FUNCT FOODS, V38, P251, DOI 10.1016/j.jff.2017.09.029
   Catalano KJ, 2010, DIABETES, V59, P1416, DOI 10.2337/db08-0675
   Cheraghpour M, 2019, PHYTOTHER RES, V33, P2118, DOI 10.1002/ptr.6406
   Chiva-Blanch G, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/5812401
   Duarte J, 2014, FOOD FUNCT, V5, P1653, DOI [10.1039/c4fo00144c, 10.1039/C4FO00144C]
   El-Shafey MM, 2014, INT J PHARM SCI, V4, P554
   Elavarasan J, 2012, J PHARM PHARMACOL, V64, P1472, DOI 10.1111/j.2042-7158.2012.01512.x
   Erbel R, 2006, HEART, V92, P137, DOI 10.1136/hrt.2004.055111
   Foote CA, 2016, FRONT PHYSIOL, V7, DOI 10.3389/fphys.2016.00285
   Giles ED, 2016, FRONT NUTR, V3, DOI 10.3389/fnut.2016.00050
   Gómez-Zorita S, 2017, J TRANSL MED, V15, DOI 10.1186/s12967-017-1343-0
   Gorinstein S, 2007, J SCI FOOD AGR, V87, P1257, DOI 10.1002/jsfa.2834
   Homayouni F, 2018, PHYTOTHER RES, V32, P1073, DOI 10.1002/ptr.6046
   Homayouni F, 2017, PHYTOTHER RES, V31, P1539, DOI 10.1002/ptr.5881
   Hussain T, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/7432797
   Hwang JT, 2009, NEW BIOTECHNOL, V26, P17, DOI 10.1016/j.nbt.2009.03.005
   Ikemura M, 2012, PHYTOTHER RES, V26, P1272, DOI 10.1002/ptr.3724
   Johnson AR, 2016, BIOCHEM BIOPH RES CO, V473, P545, DOI 10.1016/j.bbrc.2016.03.113
   Kannappan S, 2010, EUR J NUTR, V49, P101, DOI 10.1007/s00394-009-0054-6
   Karim N, 2018, TRENDS FOOD SCI TECH, V79, P35, DOI 10.1016/j.tifs.2018.06.012
   LeBlanc ES, 2018, JAMA-J AM MED ASSOC, V320, P1172, DOI 10.1001/jama.2018.7777
   Matsuda M, 2013, OBES RES CLIN PRACT, V7, pE330, DOI 10.1016/j.orcp.2013.05.004
   Morand C, 2011, AM J CLIN NUTR, V93, P73, DOI 10.3945/ajcn.110.004945
   Mosqueda-Solís A, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-32875-4
   Peng XF, 2010, FOOD CHEM, V119, P49, DOI 10.1016/j.foodchem.2009.05.083
   Pinto P, 2017, EUR J NUTR, V56, P1393, DOI 10.1007/s00394-016-1354-2
   Pons Z, 2017, BRIT J NUTR, V117, P200, DOI 10.1017/S0007114516004426
   Pu P, 2012, ARCH BIOCHEM BIOPHYS, V518, P61, DOI 10.1016/j.abb.2011.11.026
   Qazi S, 2017, CIRC-CARDIOVASC IMAG, V10, DOI 10.1161/CIRCIMAGING.117.006776
   Reagan-Shaw S, 2008, FASEB J, V22, P659, DOI 10.1096/fj.07-9574LSF
   Richard AJ, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/549750
   Rizza S, 2011, J CLIN ENDOCR METAB, V96, pE782, DOI 10.1210/jc.2010-2879
   Roohbakhsh A, 2015, LIFE SCI, V124, P64, DOI 10.1016/j.lfs.2014.12.030
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sampey BP, 2011, OBESITY, V19, P1109, DOI 10.1038/oby.2011.18
   Sansbury BE, 2014, FREE RADICAL BIO MED, V73, P383, DOI 10.1016/j.freeradbiomed.2014.05.016
   Soleimani M, 2015, KIDNEY INT, V87, P497, DOI 10.1038/ki.2014.392
   Stanimirovic J, 2015, CLIN LIPIDOL, V10, P167, DOI 10.2217/CLP.15.8
   Tchkonia T, 2013, CELL METAB, V17, P644, DOI 10.1016/j.cmet.2013.03.008
   Testai L, 2017, NUTRIENTS, V9, DOI 10.3390/nu9050502
   Tewari N, 2015, INT J OBESITY, V39, P1575, DOI 10.1038/ijo.2015.100
   Tziomalos K, 2010, NUTR METAB CARDIOVAS, V20, P140, DOI 10.1016/j.numecd.2009.08.006
   Wang XH, 2011, J PHARMACOL SCI, V117, P129, DOI 10.1254/jphs.11097FP
   Williamson G, 2017, NUTR BULL, V42, P226, DOI 10.1111/nbu.12278
   Wisnuwardani RW, 2019, EUR J NUTR, V58, P2345, DOI 10.1007/s00394-018-1787-x
   Yamamoto M, 2013, J NUTR SCI VITAMINOL, V59, P470, DOI 10.3177/jnsv.59.470
NR 54
TC 18
Z9 19
U1 1
U2 23
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD OCT
PY 2019
VL 61
AR 103504
DI 10.1016/j.jff.2019.103504
PG 9
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA IW7WW
UT WOS:000485205700035
DA 2025-06-11
ER

PT J
AU Litvinova, L
   Atochin, DN
   Fattakhov, N
   Vasilenko, M
   Zatolokin, P
   Kirienkova, E
AF Litvinova, Larisa
   Atochin, Dmitriy N.
   Fattakhov, Nikolai
   Vasilenko, Manila
   Zatolokin, Pavel
   Kirienkova, Elena
TI Nitric oxide and mitochondria in metabolic syndrome
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE metabolic syndrome; mitochondrial dysfunction; nitric oxide synthase;
   nitric oxide; nitric oxide synthase type I; nitric oxide synthase type
   II; oxide synthase type III; mitochondrial nitric oxide synthase
ID NECROSIS-FACTOR-ALPHA; OXIDATIVE STRESS; INSULIN-RESISTANCE; ENDOTHELIAL
   DYSFUNCTION; SKELETAL-MUSCLE; HAPLOGROUP N9A; DNA VARIANT; FATTY LIVER;
   OBESITY; EXPRESSION
AB Metabolic syndrome (MS) is a cluster of metabolic disorders that collectively increase the risk of cardiovascular disease. Nitric oxide (NO) plays a crucial role in the pathogeneses of MS components and is involved in different mitochondrial signaling pathways that control respiration and apoptosis. The present review summarizes the recent information regarding the interrelations of mitochondria and NO in MS. Changes in the activities of different NO synthase isoforms lead to the formation of metabolic disorders and therefore are highlighted here. Reduced endothelial NOS activity and NO bioavailability, as the main factors underlying the endothelial dysfunction that occurs in MS, are discussed in this review in relation to mitochondrial dysfunction. We also focus on potential therapeutic strategies involving NO signaling pathways that can be used to treat patients with metabolic disorders associated with mitochondrial dysfunction. The article may help researchers develop new approaches for the diagnosis, prevention and treatment of MS.
RP Litvinova, L (corresponding author), Kant Baltic Fed Univ, Lab Immunol Cellular Biotechnol, Innovat Pk,Botkina 3, Kaliningrad 236016, Kaliningrad, Russia.
EM larisalitvinova@yandex.ru
RI Atochin, Dmitriy/AAH-8843-2020; Fattakhov, Nikolai/AAD-6645-2020;
   Litvinova, Larisa/A-9672-2014; Vulf, Maria/E-4926-2017; Fattakhov,
   Nikolai/B-2170-2014; Kirienkova, Elena/B-2164-2014
OI Litvinova, Larisa/0000-0001-5231-6910; Vulf, Maria/0000-0002-4989-045X;
   Fattakhov, Nikolai/0000-0001-6707-9727; Kirienkova,
   Elena/0000-0002-5980-3321
CR Agrawal A, 2014, IMMUNOL ALLERGY CLIN, V34, P785, DOI 10.1016/j.iac.2014.07.004
   Alam MA, 2014, J DIABETES METAB DIS, V13, DOI 10.1186/2251-6581-13-60
   Alvarado-Vásquez N, 2007, DIABETES-METAB RES, V23, P559, DOI 10.1002/dmrr.743
   [Anonymous], ADV PREVENTIVE MED, DOI [10.4061/2011/365132., DOI 10.4061/2011/365132]
   Aroor AR, 2013, ENDOCRINOLOGY, V154, P2501, DOI 10.1210/en.2013-1096
   Barua A, 2011, J SURG RES, V171, P452, DOI 10.1016/j.jss.2010.07.040
   Bazzano LA, 2006, JAMA-J AM MED ASSOC, V296, P2720, DOI 10.1001/jama.296.22.2720
   Blake R, 2014, BBA-GEN SUBJECTS, V1840, P1404, DOI 10.1016/j.bbagen.2013.11.007
   Bogacka I, 2005, DIABETES, V54, P1392, DOI 10.2337/diabetes.54.5.1392
   Brookes PS, 2004, MITOCHONDRION, V3, P187, DOI 10.1016/j.mito.2003.10.001
   Chattopadhyay M, 2015, MOL CELL BIOCHEM, V399, P95, DOI 10.1007/s11010-014-2236-7
   El Assar M, 2013, J TRANSL MED, V11, DOI 10.1186/1479-5876-11-263
   El-Hattab AW, 2012, MOL GENET METAB, V107, P247, DOI 10.1016/j.ymgme.2012.06.018
   Felaco M, 2001, ANN CLIN LAB SCI, V31, P179
   Förstermann U, 2012, EUR HEART J, V33, P829, DOI 10.1093/eurheartj/ehr304
   Fuku N, 2007, AM J HUM GENET, V80, P407, DOI 10.1086/512202
   Ghafourifar P, 1999, J BIOL CHEM, V274, P31185, DOI 10.1074/jbc.274.44.31185
   Ghafourifar P, 2005, TRENDS PHARMACOL SCI, V26, P190, DOI 10.1016/j.tips.2005.02.005
   Giulivi C, 1998, J BIOL CHEM, V273, P11038, DOI 10.1074/jbc.273.18.11038
   Griendling KK, 2000, ARTERIOSCL THROM VAS, V20, P2175, DOI 10.1161/01.ATV.20.10.2175
   Heitzer T, 2000, DIABETOLOGIA, V43, P1435, DOI 10.1007/s001250051551
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Huang PL, 2009, TRENDS ENDOCRIN MET, V20, P295, DOI 10.1016/j.tem.2009.03.005
   Hulsmans M, 2012, CURR ATHEROSCLER REP, V14, P264, DOI 10.1007/s11883-012-0237-0
   Jiang YJ, 2012, J HEMATOL ONCOL, V5, DOI 10.1186/1756-8722-5-11
   Jobgen WS, 2006, J NUTR BIOCHEM, V17, P571, DOI 10.1016/j.jnutbio.2005.12.001
   Judkins CP, 2010, AM J PHYSIOL-HEART C, V298, pH24, DOI 10.1152/ajpheart.00799.2009
   Kashyap SR, 2005, J CLIN ENDOCR METAB, V90, P1100, DOI 10.1210/jc.2004-0745
   Kendrick AA, 2011, BIOCHEM J, V433, P505, DOI 10.1042/BJ20100791
   Kim JH, 2002, DIABETIC MED, V19, P681, DOI 10.1046/j.1464-5491.2002.00747.x
   Koka S, 2014, AM J PHYSIOL-HEART C, V306, pH1558, DOI 10.1152/ajpheart.00865.2013
   Korkach Iu P, 2007, Fiziol Zh, V53, P22
   LAGUENS RUBEN, 1963, EXPTL AND MOLECULAR PATHOL, V2, P203, DOI 10.1016/0014-4800(63)90035-2
   Lee HK, 1998, DIABETES RES CLIN PR, V42, P161, DOI 10.1016/S0168-8227(98)00110-7
   Lee HK, 2010, BBA-GEN SUBJECTS, V1800, P282, DOI 10.1016/j.bbagen.2009.11.010
   Lee TJF, 2000, J BIOMED SCI, V7, P16
   Levine AB, 2012, CARDIOLOGY, V122, P55, DOI 10.1159/000338150
   Litvinova LS, 2014, BIOCHEM MOSC SUPPL B, V8, P192, DOI 10.1134/S1990750814030093
   Liu CS, 2003, FREE RADICAL RES, V37, P1307, DOI 10.1080/10715760310001621342
   Liu JK, 2002, P NATL ACAD SCI USA, V99, P1876, DOI 10.1073/pnas.261709098
   Lowell BB, 2005, SCIENCE, V307, P384, DOI 10.1126/science.1104343
   Mangge H, 2014, WORLD J CARDIOL, V6, P462, DOI 10.4330/wjc.v6.i6.462
   Martin SD, 2014, BBA-GEN SUBJECTS, V1840, P1303, DOI 10.1016/j.bbagen.2013.09.019
   Martínez-Morúa A, 2013, J ASIAN NAT PROD RES, V15, P905, DOI 10.1080/10286020.2013.802687
   Merial C, 2000, AM J PHYSIOL-CELL PH, V279, pC1100, DOI 10.1152/ajpcell.2000.279.4.C1100
   Miller MW, 2013, AM J PHYSIOL-HEART C, V304, pH1624, DOI 10.1152/ajpheart.00987.2012
   Montagnani M, 2001, J BIOL CHEM, V276, P30392, DOI 10.1074/jbc.M103702200
   Mozhey OI, 2014, MOL BIOL+, V48, P590, DOI 10.1134/S0026893314040074
   Münzel T, 2010, EUR HEART J, V31, P2741, DOI 10.1093/eurheartj/ehq396
   Münzel T, 2009, J AM COLL CARDIOL, V54, P1491, DOI 10.1016/j.jacc.2009.05.066
   Münzel T, 2005, CIRC RES, V97, P618, DOI 10.1161/01.RES.0000184694.03262.6d
   Nakamura K, 1998, CIRCULATION, V98, P794, DOI 10.1161/01.CIR.98.8.794
   Nisoli E, 2003, SCIENCE, V299, P896, DOI 10.1126/science.1079368
   Nomura K, 1999, J BIOL CHEM, V274, P29294, DOI 10.1074/jbc.274.41.29294
   Pacher P, 2007, PHYSIOL REV, V87, P315, DOI 10.1152/physrev.00029.2006
   Pagel-Langenickel I, 2010, ENDOCR REV, V31, P25, DOI 10.1210/er.2009-0003
   Palmieri VO, 2011, NUTRITION, V27, P773, DOI 10.1016/j.nut.2010.08.016
   Paschos P, 2009, HIPPOKRATIA, V13, P9
   Peinado JR, 2014, PROTEOMICS, V14, P452, DOI 10.1002/pmic.201300376
   Pérez-Carreras M, 2003, HEPATOLOGY, V38, P999, DOI 10.1053/jhep.2003.50398
   Perrotta I, 2011, CARDIOVASC PATHOL, V20, P195, DOI 10.1016/j.carpath.2010.06.002
   Petersen KF, 2003, SCIENCE, V300, P1140, DOI 10.1126/science.1082889
   Pieczenik SR, 2007, EXP MOL PATHOL, V83, P84, DOI 10.1016/j.yexmp.2006.09.008
   Poulton J, 2002, DIABETIC MED, V19, P969, DOI 10.1046/j.0742-3071.2002.00836.x
   Ren J, 2010, J MOL MED, V88, P993, DOI 10.1007/s00109-010-0663-9
   Rötig A, 2009, BBA-MOL BASIS DIS, V1792, P1103, DOI 10.1016/j.bbadis.2009.06.009
   Rossmeisl M, 2000, FASEB J, V14, P1793, DOI 10.1096/fj.99-0965com
   Rush JWE, 2005, CAN J APPL PHYSIOL, V30, P442, DOI 10.1139/h05-133
   Schulz E, 2008, ANTIOXID REDOX SIGN, V10, P1115, DOI 10.1089/ars.2007.1989
   Serra D, 2013, ANTIOXID REDOX SIGN, V19, P269, DOI 10.1089/ars.2012.4875
   Shankar RR, 2000, DIABETES, V49, P684, DOI 10.2337/diabetes.49.5.684
   Shen GX, 2010, CAN J PHYSIOL PHARM, V88, P241, DOI 10.1139/Y10-018
   Shen WL, 2011, BRIT J PHARMACOL, V162, P1213, DOI 10.1111/j.1476-5381.2010.01134.x
   Shenouda SM, 2011, CIRCULATION, V124, P444, DOI 10.1161/CIRCULATIONAHA.110.014506
   Smits P, 2010, J BIOMED BIOTECHNOL, DOI 10.1155/2010/737385
   Song BJ, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/781050
   Sorriento D, 2014, SCI WORLD J, DOI 10.1155/2014/604685
   Suematsu N, 2003, CIRCULATION, V107, P1418, DOI 10.1161/01.CIR.0000055318.09997.1F
   Tanaka M, 2007, DIABETES, V56, P518, DOI 10.2337/db06-1105
   Tian XY, 2012, CIRC RES, V110, P1211, DOI [10.1161/CIRCRESAHA.111.262170, 10.1161/circresaha.111.262170]
   Turrens JF, 2003, J PHYSIOL-LONDON, V552, P335, DOI 10.1113/jphysiol.2003.049478
   Ufnal M, 2010, KARDIOL POL, V68, pS436
   Verhaar MC, 2002, ARTERIOSCL THROM VAS, V22, P6, DOI 10.1161/hq0102.102190
   Vernochet C, 2014, FASEB J, V28, P4408, DOI 10.1096/fj.14-253971
   Virág L, 2003, TOXICOL LETT, V140, P113, DOI 10.1016/S0378-4274(02)00508-8
   Yang LY, 2014, J ETHNOPHARMACOL, V156, P61, DOI 10.1016/j.jep.2014.07.054
   Ye W, 2013, MOL MED REP, V8, P1060, DOI 10.3892/mmr.2013.1616
   Yki-Jarvinen H, 2004, NEW ENGL J MED, V351, P1106, DOI 10.1056/NEJMra041001
   Youn JY, 2012, DIABETOLOGIA, V55, P2069, DOI 10.1007/s00125-012-2557-6
   Youn JY, 2014, DIABETES, V63, P2344, DOI 10.2337/db13-0719
   Yuzefovych LV, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054059
NR 91
TC 91
Z9 98
U1 1
U2 19
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD FEB 17
PY 2015
VL 6
AR 20
DI 10.3389/fphys.2015.00020
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA CG0BL
UT WOS:000352931500001
PM 25741283
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Maurantonio, M
   Ballestri, S
   Odoardi, MR
   Lonardo, A
   Loria, P
AF Maurantonio, Mauro
   Ballestri, Stefano
   Odoardi, Maria Rosaria
   Lonardo, Amedeo
   Loria, Paola
TI Treatment of Atherogenic Liver Based on the Pathogenesis of
   Nonalcoholic Fatty Liver Disease: A Novel Approach to Reduce
   Cardiovascular Risk?
SO ARCHIVES OF MEDICAL RESEARCH
LA English
DT Review
DE Atherosclerosis; Cardiovascular Risk; Metabolic syndrome; Nonalcoholic
   fatty liver disease; Pathogenesis; Treatment
ID GAMMA-GLUTAMYL-TRANSFERASE; C-REACTIVE PROTEIN; HEPATIC SUBCAPSULAR
   STEATOSIS; MUSCLE INSULIN-RESISTANCE; RENIN-ANGIOTENSIN SYSTEM;
   LIFE-STYLE INTERVENTION; VISCERAL ADIPOSE-TISSUE; TERM-FOLLOW-UP;
   METABOLIC SYNDROME; CRYPTOGENIC CIRRHOSIS
AB Nonalcoholic fatty liver disease (NAFLD), which spans a spectrum of conditions ranging from simple steatosis to progressive nonalcoholic steatohepatitis (NASH), is the most common chronic liver disease and a relevant public health issue. The prevalence of NAFLD depends on adiposity, age, gender and ethnicity. The natural history of liver disease in those with NAFLD critically depends on liver histological changes. However, cardiovascular mortality is increased in NAFLD, particularly in middle-aged adults. Against such a background, this review consists of three sections. First, data on NAFLD as a novel mechanism of increased cardiovascular risk via hyperinsulinism, prothrombotic potential, and subclinical inflammation are summarized. Next, the role of atherogenic liver in the development of manifestations of oxidative stress and atherosclerosis is emphasized. Finally, whether and how treating NAFLD will mechanistically result in reduced cardiovascular risk through ameliorated metabolic syndrome is discussed. (C) 2011 IMSS. Published by Elsevier Inc.
C1 [Maurantonio, Mauro; Ballestri, Stefano; Odoardi, Maria Rosaria; Lonardo, Amedeo; Loria, Paola] Univ Modena & Reggio Emilia, Nuovo Osped Civile St Agostino Estense Modena, Dept Internal Med Endocrinol Metab & Geriatr, I-41100 Modena, Italy.
C3 Universita di Modena e Reggio Emilia
RP Maurantonio, M (corresponding author), Univ Modena & Reggio Emilia, Dept Internal Med Metab Endocrinol & Geriatr, Operating Unit Internal Med, Nuovo Osped Civile Estense Baggiovara, I-41100 Modena, Italy.
EM m.maurantonio@ausl.mo.it
RI Ballestri, Stefano/AAQ-1541-2021; Lonardo, Amedeo/I-5911-2019
OI ballestri, stefano/0000-0002-1424-7894; Lonardo,
   Amedeo/0000-0001-9886-0698
CR Abel T, 2009, MED SCI MONITOR, V15, pMS6
   Adams LA, 2005, GASTROENTEROLOGY, V129, P113, DOI 10.1053/j.gastro.2005.04.014
   Afzali A, 2010, HEPATOLOGY, V52, P578, DOI 10.1002/hep.23717
   Ahmed MH, 2010, DIABETES OBES METAB, V12, P958, DOI 10.1111/j.1463-1326.2010.01261.x
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Angulo P, 2007, ALIMENT PHARM THER, V25, P883, DOI 10.1111/j.1365-2036.2007.03246.x
   Angulo P, 2002, NEW ENGL J MED, V346, P1221, DOI 10.1038/nrdp.2015.80
   Angulo P, 2007, HEPATOLOGY, V45, P846, DOI 10.1002/hep.21496
   [Anonymous], 2002, Gastroenterology, V123, P1702
   [Anonymous], COCHRANE DATABASE SY
   [Anonymous], ANN MED
   [Anonymous], EXP REV ENDOCIRNOL M
   Ardigò D, 2005, METABOLISM, V54, P1566, DOI 10.1016/j.metabol.2005.05.027
   Arendt BM, 2011, AM J GASTROENTEROL, V106, P78, DOI 10.1038/ajg.2010.310
   ARGO C, 2009, DIABETES CARE, V32, P209
   Arrese M, 2009, HEPATOLOGY, V49, P348, DOI 10.1002/hep.22783
   Assy N, 2010, RADIOLOGY, V254, P393, DOI 10.1148/radiol.09090769
   Athyros VG, 2006, CURR MED RES OPIN, V22, P873, DOI 10.1185/030079906X104696
   Athyros VG, 2010, LANCET, V376, P1916, DOI 10.1016/S0140-6736(10)61272-X
   ATTVALL S, 1993, J INTERN MED, V233, P327, DOI 10.1111/j.1365-2796.1993.tb00680.x
   Ayata G, 2002, HUM PATHOL, V33, P1098, DOI 10.1053/hupa.2002.129419
   Basaranoglu M, 1999, J HEPATOL, V31, P384, DOI 10.1016/S0168-8278(99)80243-8
   Bayturan O, 2010, ARCH INTERN MED, V170, P478, DOI 10.1001/archinternmed.2009.551
   Bedogni G, 2007, HEPATOLOGY, V46, P1387, DOI 10.1002/hep.21827
   Bellentani S, 1997, GUT, V41, P845, DOI 10.1136/gut.41.6.845
   Bellentani S, 2000, ANN INTERN MED, V132, P112, DOI 10.7326/0003-4819-132-2-200001180-00004
   Browning JD, 2004, AM J GASTROENTEROL, V99, P292, DOI 10.1111/j.1572-0241.2004.04059.x
   Browning JD, 2004, HEPATOLOGY, V40, P1387, DOI 10.1002/hep.20466
   Browning JD, 2004, J CLIN INVEST, V114, P147, DOI 10.1172/JCI200422422
   Browning JD, 2006, HEPATOLOGY, V44, P466, DOI 10.1002/hep.21248
   Brunt EM, 2007, MODERN PATHOL, V20, pS40, DOI 10.1038/modpathol.3800680
   Brunt EM, 1999, AM J GASTROENTEROL, V94, P2467, DOI 10.1111/j.1572-0241.1999.01377.x
   Caballería L, 2010, EUR J GASTROEN HEPAT, V22, P24, DOI 10.1097/MEG.0b013e32832fcdf0
   Caldwell SH, 1999, HEPATOLOGY, V29, P664, DOI 10.1002/hep.510290347
   Cartier A, 2008, J CLIN ENDOCR METAB, V93, P1931, DOI 10.1210/jc.2007-2191
   Catalano D, 2008, LIVER INT, V28, P1280, DOI 10.1111/j.1478-3231.2008.01742.x
   Chalasani N, 2004, AM J GASTROENTEROL, V99, P1497, DOI 10.1111/j.1572-0241.2004.30159.x
   Chan DC, 2010, DIABETES CARE, V33, P1134, DOI 10.2337/dc09-1765
   Charlotte F, 2010, HUM PATHOL, V41, P1178, DOI 10.1016/j.humpath.2009.10.025
   Charlton N, 2002, HEPATOLOGY, V35, P898, DOI 10.1053/jhep.2002.32527
   Chavaez-Tapia NC, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007340.pub2
   Chen CH, 2010, DIGEST DIS SCI, V55, P1752, DOI 10.1007/s10620-009-0935-9
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Clegg A, 2003, INT J OBESITY, V27, P1167, DOI 10.1038/sj.ijo.0802394
   Clifton PM, 2011, CURR OPIN LIPIDOL, V22, P1, DOI 10.1097/MOL.0b013e328340b8fd
   Couillard C, 2005, J CLIN ENDOCR METAB, V90, P6454, DOI 10.1210/jc.2004-2438
   Daly AK, 2011, EXPERT REV GASTROENT, V5, P253, DOI [10.1586/egh.11.18, 10.1586/EGH.11.18]
   Dam-Larsen S, 2004, GUT, V53, P750, DOI 10.1136/gut.2003.019984
   Dassanayake AS, 2009, J GASTROEN HEPATOL, V24, P1284, DOI 10.1111/j.1440-1746.2009.05831.x
   Day CP, 2006, LIVER INT, V26, P1021, DOI 10.1111/j.1478-3231.2006.01323.x
   Day CP, 1998, HEPATOLOGY, V27, P1463, DOI 10.1002/hep.510270601
   Day CP, 2006, GASTROENTEROLOGY, V130, P207, DOI 10.1053/j.gastro.2005.11.017
   de Alwis NMW, 2008, J HEPATOL, V48, pS104, DOI 10.1016/j.jhep.2008.01.009
   de Denus S, 2004, PHARMACOTHERAPY, V24, P584, DOI 10.1592/phco.24.6.584.34738
   de Kloet AD, 2010, PHYSIOL BEHAV, V100, P525, DOI 10.1016/j.physbeh.2010.03.018
   de Marco R, 1999, DIABETES CARE, V22, P756, DOI 10.2337/diacare.22.5.756
   Demir S, 2007, NEPHROL DIAL TRANSPL, V22, P1247, DOI 10.1093/ndt/gfm002
   Denzer C, 2009, J CLIN ENDOCR METAB, V94, P3872, DOI 10.1210/jc.2009-1125
   Derosa G, 2010, DRUGS, V70, P1945, DOI 10.2165/11538100-000000000-00000
   Diehl Anna Mae, 2004, Clin Liver Dis, V8, P619, DOI 10.1016/j.cld.2004.04.012
   Dietrich M, 2009, ATHEROSCLEROSIS, V205, P549, DOI 10.1016/j.atherosclerosis.2008.12.019
   Dixon JB, 2004, HEPATOLOGY, V39, P1647, DOI 10.1002/hep.20251
   Dongiovanni P, 2010, GUT, V59, P267, DOI 10.1136/gut.2009.190801
   Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI23621
   Dunn W, 2008, AM J GASTROENTEROL, V103, P2263, DOI 10.1111/j.1572-0241.2008.02034.x
   DURANTEMANGONI E, 2009, ALIMENT PHARM THER, V30, P61
   Ekstedt M, 2006, HEPATOLOGY, V44, P865, DOI 10.1002/hep.21327
   Ekstedt M, 2007, J HEPATOL, V47, P135, DOI 10.1016/j.jhep.2007.02.013
   Engeli S, 2005, HYPERTENSION, V45, P356, DOI 10.1161/01.HYP.0000154361.47683.d3
   Equitani F, 2008, DIABETES CARE, V31, P3, DOI 10.2337/dc07-0939
   Erlinger S, 2011, CLIN RES HEPATOL GAS, V35, P163, DOI 10.1016/j.clinre.2010.12.010
   Ertle J, 2011, INT J CANCER, V128, P2436, DOI 10.1002/ijc.25797
   Estep M, 2010, ALIMENT PHARM THER, V32, P487, DOI 10.1111/j.1365-2036.2010.04366.x
   Fabbrini E, 2010, J CLIN ENDOCR METAB, V95, P2727, DOI 10.1210/jc.2009-2622
   Fallo F, 2008, J HYPERTENS, V26, P2191, DOI 10.1097/HJH.0b013e32830dfe4b
   Farrell GC, 2006, HEPATOLOGY, V43, pS99, DOI 10.1002/hep.20973
   Farrell GC, 2007, J GASTROEN HEPATOL, V22, P775, DOI 10.1111/j.1440-1746.2007.05002.x
   Feldstein AE, 2004, HEPATOLOGY, V40, P185, DOI 10.1002/hep.20283
   Fernández-Miranda C, 2008, DIGEST LIVER DIS, V40, P200, DOI 10.1016/j.dld.2007.10.002
   Floch MH, 2006, J CLIN GASTROENTEROL, V40, P275, DOI 10.1097/00004836-200603000-00022
   Fontana L, 2007, DIABETES, V56, P1010, DOI 10.2337/db06-1656
   Foster T, 2011, AM J GASTROENTEROL, V106, P71, DOI 10.1038/ajg.2010.299
   Fracanzani AL, 2008, HEPATOLOGY, V48, P792, DOI 10.1002/hep.22429
   Fraser A, 2007, ARTERIOSCL THROM VAS, V27, P2729, DOI 10.1161/ATVBAHA.107.152298
   Fraser A, 2009, DIABETES CARE, V32, P741, DOI 10.2337/dc08-1870
   Fujita K, 2008, GUT, V57, P1583, DOI 10.1136/gut.2007.144550
   Gaia S, 2011, J HEPATOL, V54, P64, DOI 10.1016/j.jhep.2010.06.022
   George AS, 2009, J GASTROEN HEPATOL, V24, P399, DOI 10.1111/j.1440-1746.2008.05694.x
   Georgescu EF, 2007, J GASTROINTEST LIVER, V16, P39
   Ghouri N, 2010, HEPATOLOGY, V52, P1156, DOI 10.1002/hep.23789
   Ginsberg HN, 2006, J CLIN ENDOCR METAB, V91, P383, DOI 10.1210/jc.2005-2084
   Goessling W, 2008, GASTROENTEROLOGY, V135, P1935, DOI 10.1053/j.gastro.2008.09.018
   Grabig A, 2006, INFECT IMMUN, V74, P4075, DOI 10.1128/IAI.01449-05
   Grundy SM, 2004, CIRCULATION, V110, P227, DOI 10.1161/01.CIR.0000133317.49796.0E
   Guallar E, 2005, ANN INTERN MED, V143, P143, DOI 10.7326/0003-4819-143-2-200507190-00014
   HALFON P, 2006, ALIMENT PHARM THER, V24, P1349
   Hamabe A, 2011, J GASTROENTEROL, V46, P769, DOI 10.1007/s00535-011-0376-z
   Hamaguchi M, 2007, WORLD J GASTROENTERO, V13, P1579, DOI 10.3748/wjg.v13.i10.1579
   Harrison SA, 2009, HEPATOLOGY, V49, P80, DOI 10.1002/hep.22575
   Herrmann Wolfgang, 2002, Clin Lab, V48, P471
   Horton JD, 2002, J CLIN INVEST, V109, P1125, DOI 10.1172/JCI200215593
   Hui JM, 2004, HEPATOLOGY, V40, P46, DOI 10.1002/hep.20280
   Hui WS, 2010, EUR J EPIDEMIOL, V25, P375, DOI 10.1007/s10654-010-9459-z
   Hyogo H, 2008, METABOLISM, V57, P1711, DOI 10.1016/j.metabol.2008.07.030
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   JANZON L, 1983, DIABETOLOGIA, V25, P86
   Jasinska M, 2007, PHARMACOL REP, V59, P483
   Jepsen P, 2003, HEPATO-GASTROENTEROL, V50, P2101
   Ji C, 2004, WORLD J GASTROENTERO, V10, P1699
   Jornayvaz FR, 2010, ANNU REV NUTR, V30, P273, DOI 10.1146/annurev.nutr.012809.104726
   Joshi D, 2011, LANCET, V377, P1198, DOI 10.1016/S0140-6736(10)62001-6
   Kantartzis K, 2009, DIABETES, V58, P2616, DOI 10.2337/db09-0279
   Kersten S, 2009, ARTERIOSCL THROM VAS, V29, P969, DOI 10.1161/ATVBAHA.108.182147
   Kimura Y, 2010, J GASTROENTEROL, V45, P750, DOI 10.1007/s00535-010-0203-y
   Kiyici M, 2003, CAN J GASTROENTEROL, V17, P713, DOI 10.1155/2003/857869
   Kosoglou T, 2005, CLIN PHARMACOKINET, V44, P467, DOI 10.2165/00003088-200544050-00002
   Kotronen A, 2008, ARTERIOSCL THROM VAS, V28, P27, DOI 10.1161/ATVBAHA.107.147538
   Kotronen A, 2009, GASTROENTEROLOGY, V137, P865, DOI 10.1053/j.gastro.2009.06.005
   Kozlitina J, 2011, HEPATOLOGY, V53, P467, DOI 10.1002/hep.24072
   Lam Brian, 2010, Therap Adv Gastroenterol, V3, P121, DOI 10.1177/1756283X09359964
   Larson-Meyer DE, 2008, OBESITY, V16, P1355, DOI 10.1038/oby.2008.201
   Lavine JE, 2011, JAMA-J AM MED ASSOC, V305, P1659, DOI 10.1001/jama.2011.520
   Lee JY, 2004, J BIOL CHEM, V279, P16971, DOI 10.1074/jbc.M312990200
   Leuschner UFH, 2010, HEPATOLOGY, V52, P472, DOI 10.1002/hep.23727
   Lewis JH, 2007, HEPATOLOGY, V46, P1453, DOI 10.1002/hep.21848
   Li WJ, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-49
   Li ZP, 2003, HEPATOLOGY, V37, P343, DOI 10.1053/jhep.2003.50048
   Lindor KD, 2004, HEPATOLOGY, V39, P770, DOI 10.1002/hep.20092
   Lonardo A, 2006, J HEPATOL, V45, P454, DOI 10.1016/j.jhep.2006.06.011
   Lonardo A, 2005, ALIMENT PHARM THER, V22, P64, DOI 10.1111/j.1365-2036.2005.02600.x
   Lonardo A, 2002, DIGEST LIVER DIS, V34, P204, DOI 10.1016/S1590-8658(02)80194-3
   Lonardo A, 2002, HEPATOLOGY, V36, P514, DOI 10.1053/jhep.2002.34443
   Lonardo A, 1997, ITAL J GASTROENTEROL, V29, P351
   Lonardo A, 2006, J HEPATOL, V44, P1196, DOI 10.1016/j.jhep.2006.03.005
   Lonardo A, 2009, CLIN MED INSIGHTS-EN, V2, P81
   Lonardo A, 2011, EXPERT REV GASTROENT, V5, P279, DOI [10.1586/EGH.11.19, 10.1586/egh.11.19]
   Lonardo A, 2011, EXPERT REV GASTROENT, V5, P135, DOI [10.1586/egh.11.24, 10.1586/EGH.11.24]
   Lonardo A, 2009, AM J GASTROENTEROL, V104, P1851, DOI 10.1038/ajg.2009.233
   Loria P, 2005, ALIMENT PHARM THER, V22, P31, DOI 10.1111/j.1365-2036.2005.02592.x
   Loria P, 2004, HEPATOLOGY, V39, P1748, DOI 10.1002/hep.20252
   Loria P, 2010, DIGEST LIVER DIS, V42, P272, DOI 10.1016/j.dld.2010.01.021
   Loria P, 2008, CLIN SCI, V115, P1, DOI 10.1042/CS20070311
   Loria P, 2009, NAT REV GASTRO HEPAT, V6, P236, DOI 10.1038/nrgastro.2009.33
   Lutchman G, 2007, HEPATOLOGY, V46, P424, DOI 10.1002/hep.21661
   MACHADO MV, 2011, J GASTROENTEROL HEPA
   Marchesini G, 2005, ANN MED, V37, P333, DOI 10.1080/07853890510011445
   Marchesini G, 2005, CURR OPIN LIPIDOL, V16, P421, DOI 10.1097/01.mol.0000174153.53683.f2
   Marchesini G, 1999, AM J MED, V107, P450, DOI 10.1016/S0002-9343(99)00271-5
   Marchesini G, 2001, DIABETES, V50, P1844, DOI 10.2337/diabetes.50.8.1844
   Marra F, 2000, GASTROENTEROLOGY, V119, P466, DOI 10.1053/gast.2000.9365
   Marra F, 2008, TRENDS MOL MED, V14, P72, DOI 10.1016/j.molmed.2007.12.003
   Martínez SM, 2011, HEPATOLOGY, V53, P325, DOI 10.1002/hep.24013
   Mathurin P, 2006, GASTROENTEROLOGY, V130, P1617, DOI 10.1053/j.gastro.2006.02.024
   Mathurin P, 2009, GASTROENTEROLOGY, V137, P532, DOI 10.1053/j.gastro.2009.04.052
   Matsuzawa Y, 2004, ARTERIOSCL THROM VAS, V24, P29, DOI 10.1161/01.ATV.0000099786.99623.EF
   Matteoni CA, 1999, GASTROENTEROLOGY, V116, P1413, DOI 10.1016/S0016-5085(99)70506-8
   McPherson S, 2010, GUT, V59, P1265, DOI 10.1136/gut.2010.216077
   Mehta SR, 2008, WORLD J GASTROENTERO, V14, P3476, DOI 10.3748/wjg.14.3476
   Merat S, 2003, J HEPATOL, V38, P414, DOI 10.1016/S0168-8278(02)00441-5
   Merat S, 2003, J CLIN GASTROENTEROL, V36, P266, DOI 10.1097/00004836-200303000-00015
   Merat S, 2008, DIGEST DIS SCI, V53, P2246, DOI 10.1007/s10620-007-0109-6
   Merriman RB, 2006, J CLIN GASTROENTEROL, V40, pS30
   Mihaila RG, 2009, HEPATO-GASTROENTEROL, V56, P1117
   Mirbagheri SA, 2007, LIVER INT, V27, P891, DOI 10.1111/j.1478-3231.2007.01531.x
   Mofrad P, 2003, HEPATOLOGY, V37, P1286, DOI 10.1053/jhep.2003.50229
   Moscatiello S, 2008, MINI-REV MED CHEM, V8, P767, DOI 10.2174/138955708784912193
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Mozaffarian D, 2010, AM J CLIN NUTR, V92, P1350, DOI 10.3945/ajcn.110.003970
   Musso G, 2009, PROG LIPID RES, V48, P1, DOI 10.1016/j.plipres.2008.08.001
   Musso G, 2008, DIABETES CARE, V31, P562, DOI 10.2337/dc07-1526
   Musso G, 2010, HEPATOLOGY, V52, P79, DOI 10.1002/hep.23623
   Nelson A, 2009, J CLIN GASTROENTEROL, V43, P990, DOI 10.1097/MCG.0b013e31819c392e
   Nobili V, 2008, HEPATOLOGY, V48, P119, DOI 10.1002/hep.22336
   Ong J, 2001, LIVER TRANSPLANT, V7, P797, DOI 10.1053/jlts.2001.24644
   Pacifico L, 2010, HEPATOLOGY, V52, P1643, DOI 10.1002/hep.23890
   Paracchini V, 2005, AM J EPIDEMIOL, V162, P101, DOI 10.1093/aje/kwi174
   Park SH, 2006, J GASTROEN HEPATOL, V21, P138, DOI 10.1111/j.1440-1746.2005.04086.x
   Park SH, 2004, J GASTROEN HEPATOL, V19, P694, DOI 10.1111/j.1440-1746.2004.03362.x
   Paul M, 2006, PHYSIOL REV, V86, P747, DOI 10.1152/physrev.00036.2005
   PELLEGRINI E, 2010, NUTR METAB CARDIOVAS
   Pessayre D, 2002, AM J PHYSIOL-GASTR L, V282, pG193, DOI 10.1152/ajpgi.00426.2001
   Pessayre D, 2007, J GASTROEN HEPATOL, V22, pS20, DOI 10.1111/j.1440-1746.2006.04640.x
   Petersen KF, 2007, P NATL ACAD SCI USA, V104, P12587, DOI 10.1073/pnas.0705408104
   Petersen KF, 2010, NEW ENGL J MED, V362, P1082, DOI 10.1056/NEJMoa0907295
   Pontiroli AE, 2011, ANN SURG, V253, P484, DOI 10.1097/SLA.0b013e31820d98cb
   Postic C, 2008, J CLIN INVEST, V118, P829, DOI 10.1172/JCI34275
   Preiss D, 2008, CLIN SCI, V115, P141, DOI 10.1042/CS20070402
   Promrat K, 2010, HEPATOLOGY, V51, P121, DOI 10.1002/hep.23276
   Rafiq N, 2009, CLIN GASTROENTEROL H, V7, P234, DOI 10.1016/j.cgh.2008.11.005
   Rakoski MO, 2010, ALIMENT PHARM THER, V32, P1211, DOI 10.1111/j.1365-2036.2010.04467.x
   Ran JM, 2004, AM J PHYSIOL-ENDOC M, V287, pE955, DOI 10.1152/ajpendo.00199.2004
   Ran JM, 2006, METABOLISM, V55, P478, DOI 10.1016/j.metabol.2005.10.009
   Ratziu V, 2010, HEPATOLOGY, V52, P2206, DOI 10.1002/hep.24042
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Reddy JK, 2006, AM J PHYSIOL-GASTR L, V290, pG852, DOI 10.1152/ajpgi.00521.2005
   Rhee EJ, 2011, AM J MED, V124, P69, DOI 10.1016/j.amjmed.2010.08.012
   Ribeiro PS, 2004, AM J GASTROENTEROL, V99, P1708, DOI 10.1111/j.1572-0241.2004.40009.x
   Riquelme A, 2009, LIVER INT, V29, P82, DOI 10.1111/j.1478-3231.2008.01823.x
   Romeo S, 2008, NAT GENET, V40, P1461, DOI 10.1038/ng.257
   Salvi P, 2010, J HYPERTENS, V28, P1699, DOI 10.1097/HJH.0b013e32833a7de6
   Samuel VT, 2010, LANCET, V375, P2267, DOI 10.1016/S0140-6736(10)60408-4
   Sanyal AJ, 2001, GASTROENTEROLOGY, V120, P1183, DOI 10.1053/gast.2001.23256
   Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929
   Saremi A, 2010, AM J THER, V17, pE56, DOI 10.1097/MJT.0b013e31819cdc9a
   Sazci A, 2008, CELL BIOCHEM FUNCT, V26, P291, DOI 10.1002/cbf.1424
   Schenk S, 2008, J CLIN INVEST, V118, P2992, DOI 10.1172/JCI34260
   Schindhelm RK, 2007, ATHEROSCLEROSIS, V191, P391, DOI 10.1016/j.atherosclerosis.2006.04.006
   Schiopu A, 2004, CIRCULATION, V110, P2047, DOI 10.1161/01.CIR.0000143162.56057.B5
   Schmieder RE, 2007, LANCET, V369, P1208, DOI 10.1016/S0140-6736(07)60242-6
   Schult A, 2011, SCAND J GASTROENTERO, V46, P738, DOI 10.3109/00365521.2011.560679
   Schulze MB, 2009, DIABETES CARE, V32, P2116, DOI 10.2337/dc09-0197
   Schuppan D, 2010, LIVER INT, V30, P795, DOI 10.1111/j.1478-3231.2010.02264.x
   Segarra-Newnham M, 2007, PHARMACOTHERAPY, V27, P845, DOI 10.1592/phco.27.6.845
   Serviddio G, 2010, CURR MED CHEM, V17, P2325, DOI 10.2174/092986710791698530
   Shah K, 2009, OBESITY, V17, P2162, DOI 10.1038/oby.2009.126
   Sharma AM, 2002, HYPERTENSION, V40, P609, DOI 10.1161/01.HYP.0000036448.44066.53
   Shi H, 2006, J CLIN INVEST, V116, P3015, DOI 10.1172/JCI28898
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Sloniger JA, 2005, AM J PHYSIOL-ENDOC M, V288, pE1074, DOI 10.1152/ajpendo.00396.2004
   Smith SC, 2004, CIRCULATION, V109, P3112, DOI 10.1161/01.CIR.0000133427.35111.67
   Söderberg C, 2010, HEPATOLOGY, V51, P595, DOI 10.1002/hep.23314
   Sofi F, 2010, INT J FOOD SCI NUTR, V61, P792, DOI 10.3109/09637486.2010.487480
   Sookoian S, 2008, J HEPATOL, V49, P600, DOI 10.1016/j.jhep.2008.06.012
   Sorrentino P, 2010, AM J GASTROENTEROL, V105, P336, DOI 10.1038/ajg.2009.587
   Spadaro L, 2008, DIGEST LIVER DIS, V40, P194, DOI 10.1016/j.dld.2007.10.003
   Spencer MD, 2011, GASTROENTEROLOGY, V140, P976, DOI 10.1053/j.gastro.2010.11.049
   Starley BQ, 2010, HEPATOLOGY, V51, P1820, DOI 10.1002/hep.23594
   Stefan N, 2008, ARCH INTERN MED, V168, P1609, DOI 10.1001/archinte.168.15.1609
   Stepanova M, 2010, GUT, V59, P1410, DOI 10.1136/gut.2010.213553
   Strasak AM, 2008, ARTERIOSCL THROM VAS, V28, P1857, DOI 10.1161/ATVBAHA.108.170597
   Struben VMD, 2000, AM J MED, V108, P9, DOI 10.1016/S0002-9343(99)00315-0
   Sumida Y, 2009, HEPATOL RES, V39, P213, DOI 10.1111/j.1872-034X.2008.00442.x
   Svegliati-Baroni G, 2006, AM J PATHOL, V169, P846, DOI 10.2353/ajpath.2006.050953
   Tanaka N, 2008, J CLIN GASTROENTEROL, V42, P413, DOI 10.1097/MCG.0b013e31815591aa
   Tancevski I, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008722
   Targher G, 2008, DIABETOLOGIA, V51, P444, DOI 10.1007/s00125-007-0897-4
   Targher G, 2005, DIABETES, V54, P3541, DOI 10.2337/diabetes.54.12.3541
   Targher G, 2007, DIABETES CARE, V30, P2119, DOI 10.2337/dc07-0349
   Targher G, 2007, J HEPATOL, V46, P1126, DOI 10.1016/j.jhep.2007.01.021
   Targher G, 2007, ATHEROSCLEROSIS, V191, P235, DOI 10.1016/j.atherosclerosis.2006.08.021
   Targher G, 2006, J HEPATOL, V45, P454, DOI 10.1016/j.jhep.2006.06.010
   Targher G, 2010, NEW ENGL J MED, V363, P1341, DOI 10.1056/NEJMra0912063
   Toledo FGS, 2006, DIABETES CARE, V29, P1845, DOI 10.2337/dc06-0455
   Torun D, 2005, PERITON DIALYSIS INT, V25, P596
   Upchurch GR, 1997, J BIOL CHEM, V272, P17012, DOI 10.1074/jbc.272.27.17012
   Utzschneider KM, 2006, J CLIN ENDOCR METAB, V91, P4753, DOI 10.1210/jc.2006-0587
   Valenti L, 2011, QJM-INT J MED, V104, P141, DOI 10.1093/qjmed/hcq170
   Valenti L, 2008, DIABETES, V57, P1355, DOI 10.2337/db07-0714
   Valenti L, 2007, AM J GASTROENTEROL, V102, P1251, DOI 10.1111/j.1572-0241.2007.01192.x
   Valenti L, 2010, HEPATOLOGY, V51, P1209, DOI 10.1002/hep.23622
   Vanni E, 2010, DIGEST LIVER DIS, V42, P320, DOI 10.1016/j.dld.2010.01.016
   Vega GL, 2008, J INVEST MED, V56, P780, DOI 10.2310/JIM.0b013e318177024d
   Velloso LA, 1996, P NATL ACAD SCI USA, V93, P12490, DOI 10.1073/pnas.93.22.12490
   Vijay-Kumar M, 2010, SCIENCE, V328, P228, DOI 10.1126/science.1179721
   Villanova N, 2005, HEPATOLOGY, V42, P473, DOI 10.1002/hep.20781
   Völzke H, 2005, WORLD J GASTROENTERO, V11, P1848
   Vuppalanchi R, 2009, HEPATOLOGY, V49, P306, DOI 10.1002/hep.22603
   Wang CL, 2008, WORLD J GASTROENTERO, V14, P1598, DOI 10.3748/wjg.14.1598
   Wang RT, 2003, AM J MED, V115, P554, DOI 10.1016/S0002-9343(03)00449-2
   WANLESS IR, 1989, MODERN PATHOL, V2, P69
   Watanabe S, 2008, J GASTROENTEROL, V43, P509, DOI 10.1007/s00535-008-2193-6
   Wei Y, 2008, AM J PHYSIOL-ENDOC M, V294, pE345, DOI 10.1152/ajpendo.00456.2007
   Westerbacka J, 2007, DIABETES, V56, P2759, DOI 10.2337/db07-0156
   Westerink J, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-13
   Wieckowska A, 2008, AM J GASTROENTEROL, V103, P1372, DOI 10.1111/j.1572-0241.2007.01774.x
   Wong VWS, 2010, GUT, V59, P969, DOI 10.1136/gut.2009.205088
   WONG VW, 2011, GUT             0520
   Yokohama S, 2004, HEPATOLOGY, V40, P1222, DOI 10.1002/hep.20420
   Yoneda M, 2007, J GASTROENTEROL, V42, P573, DOI 10.1007/s00535-007-2060-x
   Yoon D, 2005, J KOREAN MED SCI, V20, P421, DOI 10.3346/jkms.2005.20.3.421
   Yun KE, 2009, ATHEROSCLEROSIS, V205, P533, DOI 10.1016/j.atherosclerosis.2008.12.012
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
   Yvan-Charvet L, 2005, DIABETES, V54, P991, DOI 10.2337/diabetes.54.4.991
   Zarich SW, 2010, CURR DIABETES REP, V10, P24, DOI 10.1007/s11892-009-0083-9
   Zein CO, 2011, J HEPATOL, V54, P753, DOI 10.1016/j.jhep.2010.07.040
   Zhu FS, 2008, WORLD J GASTROENTERO, V14, P6395, DOI 10.3748/wjg.14.6395
NR 276
TC 33
Z9 35
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0188-4409
EI 1873-5487
J9 ARCH MED RES
JI Arch. Med. Res.
PD JUL
PY 2011
VL 42
IS 5
BP 337
EP 353
DI 10.1016/j.arcmed.2011.08.004
PG 17
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 830MR
UT WOS:000295661600001
PM 21843565
DA 2025-06-11
ER

PT J
AU Jacob, G
   Ocytil, Y
   Brenner, B
AF Jacob, Giris
   Ocytil, Yoab
   Brenner, Benjamin
TI The Overlooked Risk of Venous Thromboembolism in Psychiatric Patients:
   Epidemiology, Pathophysiology, and Implications for Clinical Care
SO SEMINARS IN THROMBOSIS AND HEMOSTASIS
LA English
DT Article
DE psychiatric diseases; venous thromboembolism; hypercoagulability;
   metabolic syndrome; antipsychotic drugs
ID PULMONARY-EMBOLISM; METABOLIC SYNDROME; DIABETES-MELLITUS;
   ANTIPSYCHOTIC-DRUGS; THROMBIN GENERATION; OXIDATIVE STRESS;
   MENTAL-ILLNESS; COAGULATION; SCHIZOPHRENIA; PREVALENCE
AB Psychiatric patients face a significantly shorter life expectancy than the general population due to a complex interplay of medical, behavioral, and social factors. Venous thromboembolism (VTE), encompassing both pulmonary embolism and deep vein thrombosis, is an underrecognized yet critical contributor to morbidity and mortality in this population. Evidence suggests a two to three times higher prevalence of VTE in psychiatric patients compared to the general population, with incidence rates up to 4.5 per 1,000 person-years. This elevated risk is attributed to a hypercoagulable-hypofibrinolytic state. It is influenced by metabolic abnormalities, pro-inflammatory pathways, antipsychotic medications, and genetic factors. Health care biases and reduced treatment compliance further exacerbate the burden. This review explores the epidemiology, pathophysiology, and mechanistic underpinnings of VTE in psychiatric populations, emphasizing the role of metabolic syndrome and antipsychotic therapy. To mitigate mortality and enhance outcomes for these high-risk individuals, it is imperative to address this issue through improved risk stratification and preventive strategies.
C1 [Jacob, Giris; Ocytil, Yoab] Sourasky Med Ctr, Internal Med, Tel Aviv, Israel.
   [Jacob, Giris] Sourasky Med Ctr, Recanati Res Ctr, Tel Aviv, Israel.
   [Jacob, Giris] Tel Aviv Univ, Fac Med, Tel Aviv, Israel.
   [Brenner, Benjamin] Rambam Hlth Care Campus, Dept Hematol, H_efa, Israel.
   [Brenner, Benjamin] Technion Israel Inst Technol, Fac Med, Haifa, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv Sourasky
   Medical Center; Tel Aviv University; Sackler Faculty of Medicine; Tel
   Aviv Sourasky Medical Center; Tel Aviv University; Rambam Health Care
   Campus; Technion Israel Institute of Technology; Rappaport Faculty of
   Medicine
RP Jacob, G (corresponding author), Tel Aviv Univ, Fac Med, Tel Aviv Sourasky Med Ctr, Internal Med Div, Tel Aviv, Israel.
EM jacobgi@tlvmc.gov.il
FU Jacob Recanati Research Funding, NYC, United States; Tel Aviv, Israel
FX The authors have received funding from Jacob Recanati Research Funding,
   NYC, United States and Tel Aviv, Israel.
CR Alberg AJ, 2002, TOXICOLOGY, V180, P121, DOI 10.1016/S0300-483X(02)00386-4
   Ali-Saleh M, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0158652
   Altamura AC, 2014, PSYCHIAT CLIN NEUROS, V68, P21, DOI 10.1111/pcn.12089
   Aoki R, 2022, PSYCHIAT CLIN NEUROS, V76, P361, DOI 10.1111/pcn.13372
   Aso Y, 2004, CLIN CHIM ACTA, V348, P139, DOI 10.1016/j.cccn.2004.05.006
   Axelsson S, 2007, CLIN EXP PHARMACOL P, V34, P775, DOI 10.1111/j.1440-1681.2007.04650.x
   Aziz KA, 2024, INT CLIN PSYCHOPHARM, V39, P257, DOI 10.1097/YIC.0000000000000538
   Barbar S, 2010, J THROMB HAEMOST, V8, P2450, DOI 10.1111/j.1538-7836.2010.04044.x
   BAYNES JW, 1991, DIABETES, V40, P405, DOI 10.2337/diabetes.40.4.405
   Bentur OS, 2018, SEMIN THROMB HEMOST, V44, P662, DOI 10.1055/s-0038-1660853
   Bernardo M, 2021, ADV THER, V38, P2491, DOI 10.1007/s12325-021-01689-8
   Björkenstam E, 2012, BMJ OPEN, V2, DOI 10.1136/bmjopen-2011-000778
   Boden G, 2007, J CLIN ENDOCR METAB, V92, P4352, DOI 10.1210/jc.2007-0933
   Booth WA, 2024, FRONT PUBLIC HEALTH, V12, DOI 10.3389/fpubh.2024.1384521
   Boushra M., 2024, STATPEARLS INTERNET
   Carr ME, 2001, J DIABETES COMPLICAT, V15, P44, DOI 10.1016/S1056-8727(00)00132-X
   Carrizo E, 2008, SCHIZOPHR RES, V103, P83, DOI 10.1016/j.schres.2008.03.004
   CERIELLO A, 1993, DIABETOLOGIA, V36, P1119, DOI 10.1007/BF00401055
   Chiva-Blanch G, 2021, TRANSL RES, V235, P1, DOI 10.1016/j.trsl.2021.04.003
   Chow V, 2015, SCHIZOPHR RES, V162, P175, DOI 10.1016/j.schres.2014.12.042
   Compton WM, 2007, ARCH GEN PSYCHIAT, V64, P566, DOI 10.1001/archpsyc.64.5.566
   Corrigan PW, 2014, PSYCHOL SCI PUBL INT, V15, P37, DOI 10.1177/1529100614531398
   Darvall KAL, 2007, EUR J VASC ENDOVASC, V33, P223, DOI 10.1016/j.ejvs.2006.10.006
   Davì G, 2002, JAMA-J AM MED ASSOC, V288, P2008, DOI 10.1001/jama.288.16.2008
   De Hert M, 2012, EUR PSYCHIAT, V27
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   De Hert M, 2009, WORLD PSYCHIATRY, V8, P15
   Delluc A, 2012, THROMB RES, V130, P859, DOI 10.1016/j.thromres.2012.08.296
   Dentali F, 2009, SEMIN THROMB HEMOST, V35, P451, DOI 10.1055/s-0029-1234140
   Dicks AB, 2024, J CLIN MED, V13, DOI 10.3390/jcm13020362
   Ellis N, 2019, BJPSYCH BULL, V43, P255, DOI 10.1192/bjb.2019.25
   Engin A., 2024, OBESITY LIPOTOXICITY
   Fernández JA, 2002, BLOOD CELL MOL DIS, V29, P73, DOI 10.1006/bcmd.2002.0542
   Franz M, 2024, J PSYCHIATR RES, V169, P184, DOI 10.1016/j.jpsychires.2023.11.038
   Gardner TA, 2024, THROMB J, V22, DOI 10.1186/s12959-024-00605-8
   Garrido-Torres N, 2021, PSYCHOL MED, V51, P2307, DOI 10.1017/S0033291721002853
   Geiser F, 2012, J NERV MENT DIS, V200, P721, DOI 10.1097/NMD.0b013e3182613fa5
   Grant PJ, 2007, J INTERN MED, V262, P157, DOI 10.1111/j.1365-2796.2007.01824.x
   Gregson J, 2019, JAMA CARDIOL, V4, P163, DOI 10.1001/jamacardio.2018.4537
   Gris JC, 2015, THROMB RES, V135, pS56, DOI 10.1016/S0049-3848(15)50445-3
   Hägg S, 2008, DRUG SAFETY, V31, P685
   Hilger H, 2016, INT J PSYCHIAT CLIN, V20, P187, DOI 10.3109/13651501.2016.1174274
   Hoirisch-Clapauch S, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2015.204
   Hoirisch-Clapauch S, 2013, MED HYPOTHESES, V80, P137, DOI 10.1016/j.mehy.2012.11.011
   Holt RIG, 2015, NAT REV ENDOCRINOL, V11, P79, DOI 10.1038/nrendo.2014.203
   Holt RIG, 2011, METABOLIC SYNDROME, 2ND EDITION, P177
   Ishida T, 2014, PSYCHOSOMATICS, V55, P69, DOI 10.1016/j.psym.2013.04.001
   Ishioka M, 2015, NEUROPSYCH DIS TREAT, V11, P477, DOI 10.2147/NDT.S75176
   Jönsson AK, 2018, CNS DRUGS, V32, P47, DOI 10.1007/s40263-018-0495-7
   Kalman D, 2005, AM J ADDICTION, V14, P106, DOI 10.1080/10550490590924728
   Kim V, 2014, COPD-J COPD FDN, V1, P239, DOI 10.15326/jcopdf.1.2.2014.0133
   Kleijer BC, 2010, J CLIN PSYCHOPHARM, V30, P526, DOI 10.1097/JCP.0b013e3181f0e87d
   Kowal C, 2020, PSYCHOSOM MED, V82, P838, DOI 10.1097/PSY.0000000000000863
   Kozlowska E, 2019, PSYCHIAT RES, V272, P540, DOI 10.1016/j.psychres.2018.12.138
   Lawrence David, 2013, BMJ, V346, pf2539, DOI 10.1136/bmj.f2539
   Lê Cook B, 2014, JAMA-J AM MED ASSOC, V311, P172, DOI 10.1001/jama.2013.284985
   Leucht S, 2024, AM J PSYCHIAT, V181, P865, DOI 10.1176/appi.ajp.20240738
   Levi M, 2011, CRIT CARE CLIN, V27, P281, DOI 10.1016/j.ccc.2010.12.009
   Li X, 2024, ANTIOXID REDOX SIGN, V40, P968, DOI 10.1089/ars.2023.0524
   Lim GY, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-21243-x
   Lin CE, 2019, GEN HOSP PSYCHIAT, V61, P34, DOI 10.1016/j.genhosppsych.2019.10.003
   Lindekilde N, 2022, DIABETOLOGIA, V65, P440, DOI 10.1007/s00125-021-05609-x
   Liperoti R, 2005, ARCH INTERN MED, V165, P2677, DOI 10.1001/archinte.165.22.2677
   Mackin P, 2005, DIABETOLOGIA, V48, P215, DOI 10.1007/s00125-004-1641-y
   Masopust J, 2012, PSYCHIAT CLIN NEUROS, V66, P541, DOI 10.1111/pcn.12001
   MEADE TW, 1986, LANCET, V2, P533, DOI 10.1016/S0140-6736(86)90111-X
   Mertens I, 2006, INT J OBESITY, V30, P1308, DOI 10.1038/sj.ijo.0803189
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Momtazmanesh S, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00892
   Morel-Kopp MC, 2009, J THROMB HAEMOST, V7, P573, DOI 10.1111/j.1538-7836.2009.03278.x
   Nauffal D, 2012, J THROMB HAEMOST, V10, P1752, DOI 10.1111/j.1538-7836.2012.04829.x
   Nedeljkovic ZS, 2003, POSTGRAD MED J, V79, P195, DOI 10.1136/pmj.79.930.195
   Newcomer JW, 2005, CNS SPECTRUMS, V10, P12, DOI 10.1017/S1092852900025177
   Nieuwdorp M, 2005, CURR OPIN PHARMACOL, V5, P155, DOI 10.1016/j.coph.2004.10.003
   Rarrick C, 2020, ANN PHARMACOTHER, V54, P97, DOI 10.1177/1060028019870874
   Ray JG, 2002, THROMB HAEMOSTASIS, V88, P205
   Ruhe Ann Marie, 2018, Ment Health Clin, V8, P68, DOI 10.9740/mhc.2018.03.068
   Santa Cruz EC, 2021, BBA-PROTEINS PROTEOM, V1869, DOI 10.1016/j.bbapap.2021.140657
   Sapota-Zareba K, 2023, PSYCHIATR POL, V57, P955, DOI 10.12740/PP/152585
   Song RZ, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.678384
   Stefanovic V, 2013, VOJNOSANIT PREGL, V70, P903, DOI 10.2298/VSP1310903S
   Susai SR, 2023, SCHIZOPHRENIA BULL, V49, P893, DOI 10.1093/schbul/sbac201
   Takeshima M, 2020, NEUROPSYCH DIS TREAT, V16, P579, DOI 10.2147/NDT.S243308
   Tsai AW, 2002, ARCH INTERN MED, V162, P1182, DOI 10.1001/archinte.162.10.1182
   TSUANG MT, 1980, ARCH GEN PSYCHIAT, V37, P979
   van Winkel R, 2010, SCHIZOPHR RES, V121, P193, DOI 10.1016/j.schres.2010.05.030
   Vankwani S, 2024, METAB BRAIN DIS, V39, P855, DOI 10.1007/s11011-024-01351-6
   Velasco-Rodríguez D, 2020, THROMB RES, V196, P425, DOI 10.1016/j.thromres.2020.09.025
   von Känel R, 2020, WORLD J BIOL PSYCHIA, V21, P766, DOI 10.1080/15622975.2019.1696475
   Walker ER, 2015, JAMA PSYCHIAT, V72, P334, DOI 10.1001/jamapsychiatry.2014.2502
   Wallaschofski H, 2003, HORM METAB RES, V35, P228
   Ward J, 2023, BLOOD ADV, V7, P5341, DOI 10.1182/bloodadvances.2023010562
   Waters K, 2021, J AM PHARM ASSOC, V61, pE53, DOI 10.1016/j.japh.2020.07.017
   Wei YJ, 2018, MOL MED REP, V17, P1724, DOI 10.3892/mmr.2017.8070
   Wilkowska A, 2018, PSYCHIATR POL, V52, P421, DOI 10.12740/PP/78891
   Yousefzadeh G, 2024, ENDOCRIN DIAB METAB, V7, DOI 10.1002/edm2.468
   Zghouzi M, 2023, ANN AM THORAC SOC, V20, P1571, DOI 10.1513/AnnalsATS.202302-091OC
   Zheng CJ, 2023, THER ADV PSYCHOPHARM, V13, DOI 10.1177/20451253231200257
NR 98
TC 0
Z9 0
U1 2
U2 2
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0094-6176
EI 1098-9064
J9 SEMIN THROMB HEMOST
JI Semin. Thromb. Hemost.
PD JUN
PY 2025
VL 51
IS 04
BP 430
EP 437
DI 10.1055/s-0044-1800968
EA DEC 2024
PG 8
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 2QB1B
UT WOS:001377294900001
PM 39672190
DA 2025-06-11
ER

PT J
AU Reyad-ul-Ferdous, M
   Song, YF
AF Reyad-ul-Ferdous, Md.
   Song, Yongfeng
TI Pharmacological potential of ferulic acid for the treatment of metabolic
   syndrome and its mechanism of action: Review
SO PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Review
DE Obesity and Metabolic diseases; Lipid profiling and Glucose
   dysreg-ulation; Cardioprotective; Antioxidant; Inflammation and
   Hepatoprotective
ID HIGH-FAT DIET; PREVENTS LIVER-INJURY; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; HIGH-CARBOHYDRATE; LIPID-METABOLISM; DIOSBULBIN B; RAT MODEL;
   IN-VIVO; INFLAMMATION
AB Recently, obesity causes vital mortality around the globe. Last decade, obesity-related diseases increased significantly worldwide. Even though, effective drugs are not available to treat metabolic diseases such as cardiovascular diseases, Parkinson's, obesity, and hypertension. Emergence and identifying new drug moieties to treat such metabolic diseases became imperative. Nature is a vital source of remedies and isolates new effective and nontoxic drug candidates. Ferulic acid is a significant phenolic compound that is abundant in various fruits, rice oil, and vegetables. This study highlighted the beneficial effects of ferulic acid for the treatment of metabolic syndrome or obesity. Similarly, in this study, we have highlighted the therapeutic purpose of ferulic acid in treating metabolic syndrome, its mechanism of action as well as its potential pharmacological effect using animal models. Further investigations are needed to demonstrate the significant mechanism of action in clinical trials using the human species.
C1 [Reyad-ul-Ferdous, Md.; Song, Yongfeng] Shandong Univ, Shandong Prov Hosp, Cheeloo Coll Med, Dept Endocrinol & Metab, Jinan, Peoples R China.
   [Reyad-ul-Ferdous, Md.] Shandong Univ, Cheeloo Coll Med, Dept Internal Med, Jinan, Shandong, Peoples R China.
   [Reyad-ul-Ferdous, Md.; Song, Yongfeng] Shandong Prov Key Lab Endocrinol & Lipid Metab, Jinan 250021, Shandong, Peoples R China.
   [Song, Yongfeng] Shandong First Med Univ, Shandong Prov Hosp, Dept Endocrinol & Metab, Jinan, Shandong, Peoples R China.
   [Reyad-ul-Ferdous, Md.; Song, Yongfeng] Shandong Acad Clin Med, Shandong Inst Endocrinol & Metab, Jinan 250021, Shandong, Peoples R China.
   [Reyad-ul-Ferdous, Md.; Song, Yongfeng] Shandong Engn Res Ctr Stem Cell & Gene Therapy End, Jinan 250021, Shandong, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical
   Sciences; Shandong University; Shandong University; Shandong First
   Medical University & Shandong Academy of Medical Sciences
RP Reyad-ul-Ferdous, M; Song, YF (corresponding author), Shandong Univ, Shandong Prov Hosp, Cheeloo Coll Med, Dept Endocrinol & Metab, Jinan, Peoples R China.; Reyad-ul-Ferdous, M (corresponding author), Shandong Univ, Cheeloo Coll Med, Dept Internal Med, Jinan, Shandong, Peoples R China.; Reyad-ul-Ferdous, M; Song, YF (corresponding author), Shandong Prov Key Lab Endocrinol & Lipid Metab, Jinan 250021, Shandong, Peoples R China.; Song, YF (corresponding author), Shandong First Med Univ, Shandong Prov Hosp, Dept Endocrinol & Metab, Jinan, Shandong, Peoples R China.; Reyad-ul-Ferdous, M; Song, YF (corresponding author), Shandong Acad Clin Med, Shandong Inst Endocrinol & Metab, Jinan 250021, Shandong, Peoples R China.; Reyad-ul-Ferdous, M; Song, YF (corresponding author), Shandong Engn Res Ctr Stem Cell & Gene Therapy End, Jinan 250021, Shandong, Peoples R China.
EM rockyreyad@sdu.edu.cn; songyf@sdu.edu.cn
RI Ferdous, Md. Reyad-ul-/AAK-6745-2021
OI Ferdous, Md. Reyad-ul/0000-0003-4775-6852; Song,
   yongfeng/0000-0001-8934-3154
FU National Natural Science Foundation; Shandong Provincial Natural Science
   Foundation;  [81922016];  [81870607];  [ZR2019JQ25]
FX Acknowledgment Funding This study was supported by grants from the
   National Natural Science Foundation (81922016, 81870607) and the
   Shandong Provincial Natural Science Foundation (ZR2019JQ25) of China.
CR Adam A, 2002, J NUTR, V132, P1962, DOI 10.1093/jn/132.7.1962
   Anderson JL, 2017, NEW ENGL J MED, V376, P2053, DOI 10.1056/NEJMra1606915
   Anis E, 2020, PHYTOTHER RES, V34, P214, DOI 10.1002/ptr.6523
   Ardiansyah, 2008, J AGR FOOD CHEM, V56, P2825, DOI 10.1021/jf072896y
   Aydin S, 2014, NUTRITION, V30, P1, DOI 10.1016/j.nut.2013.05.013
   Azam MS, 2022, PHARM RES-DORDR, V39, P611, DOI 10.1007/s11095-022-03237-7
   Balasubashini MS, 2003, ACTA DIABETOL, V40, P118, DOI 10.1007/s00592-003-0099-6
   Bao YF, 2019, INT IMMUNOPHARMACOL, V77, DOI 10.1016/j.intimp.2019.105980
   Bourne L, 2000, FREE RADICAL RES, V32, P273, DOI 10.1080/10715760000300281
   Chaudhary A, 2019, RECENT PATENTS INFLA, V13, P115, DOI 10.2174/1872213X13666190621125048
   Chiang HM, 2012, FOOD CHEM TOXICOL, V50, P4260, DOI 10.1016/j.fct.2012.08.018
   Cui LL, 2013, J ALZHEIMERS DIS, V37, P19, DOI 10.3233/JAD-130164
   Das U, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0097599
   de Melo TS, 2017, BRAZ J MED BIOL RES, V50, DOI [10.1590/1414-431X20165630, 10.1590/1414-431x20165630]
   DeFronzo RA, 2009, DIABETES CARE, V32, pS157, DOI 10.2337/dc09-S302
   El-Ashmawy NE, 2018, BIOMED PHARMACOTHER, V99, P504, DOI 10.1016/j.biopha.2018.01.036
   Enriori PJ, 2006, OBESITY, V14, P254
   Erbil G, 2019, BRATISL MED J, V120, P372, DOI 10.4149/BLL_2019_061
   Fadel A, 2018, INT J BIOL MACROMOL, V109, P819, DOI 10.1016/j.ijbiomac.2017.11.055
   Fan HM, 2016, SCI REP-UK, V6, DOI 10.1038/srep21521
   Fizur M, 2015, EUR J PHARMACOL, V754, P165, DOI 10.1016/j.ejphar.2015.02.028
   Ghosh S, 2017, FOOD CHEM TOXICOL, V103, P41, DOI 10.1016/j.fct.2017.02.028
   Gogoi B, 2014, BIOCHEM BIOPH RES CO, V452, P382, DOI 10.1016/j.bbrc.2014.08.079
   Hamaguchi T, 2009, AM J PATHOL, V175, P2557, DOI 10.2353/ajpath.2009.090417
   Hernandez-Gea V, 2011, ANNU REV PATHOL-MECH, V6, P425, DOI 10.1146/annurev-pathol-011110-130246
   Huang TJ, 2005, MOL CELL NEUROSCI, V28, P42, DOI 10.1016/j.mcn.2004.08.009
   Jain PG, 2018, MOL BIOL REP, V45, P1357, DOI 10.1007/s11033-018-4297-2
   Salazar-López NJ, 2017, NUTRIENTS, V9, DOI 10.3390/nu9070675
   Jung UJ, 2014, INT J MOL SCI, V15, P6184, DOI 10.3390/ijms15046184
   Kahn SE, 2006, NATURE, V444, P840, DOI 10.1038/nature05482
   KAMEI T, 1986, CHEM PHARM BULL, V34, P409
   Kelainy EG, 2019, ENVIRON SCI POLLUT R, V26, P31675, DOI 10.1007/s11356-019-06099-6
   Kim EO, 2012, FOOD CHEM TOXICOL, V50, P1309, DOI 10.1016/j.fct.2012.02.011
   Kim HS, 2004, BIOL PHARM BULL, V27, P120, DOI 10.1248/bpb.27.120
   Kim J, 2011, J ETHNOPHARMACOL, V137, P427, DOI 10.1016/j.jep.2011.04.072
   Klop B, 2013, NUTRIENTS, V5, P1218, DOI 10.3390/nu5041218
   Knauf C, 2006, ENDOCRINOLOGY, V147, P4067, DOI 10.1210/en.2005-1536
   Li T, 2016, AM J CHINESE MED, V44, P1543, DOI 10.1142/S0192415X16500865
   Li XH, 2015, INFLAMM RES, V64, P1, DOI 10.1007/s00011-014-0772-y
   Li XL, 2022, BIOCHEM BIOPH RES CO, V594, P168, DOI 10.1016/j.bbrc.2022.01.059
   Lim KH, 2013, J GINSENG RES, V37, P273, DOI 10.5142/jgr.2013.37.273
   Loos RJF, 2008, NAT GENET, V40, P768, DOI 10.1038/ng.140
   Mahmoud AM, 2019, FOOD FUNCT, V10, P4593, DOI [10.1039/c9fo00114j, 10.1039/C9FO00114J]
   Manach C, 2004, AM J CLIN NUTR, V79, P727, DOI 10.1093/ajcn/79.5.727
   Mancuso C, 2014, FOOD CHEM TOXICOL, V65, P185, DOI 10.1016/j.fct.2013.12.024
   Mezzetti A, 2000, CARDIOVASC RES, V47, P475, DOI 10.1016/S0008-6363(00)00118-8
   Mir SM, 2018, BIOMED PHARMACOTHER, V100, P304, DOI 10.1016/j.biopha.2018.01.169
   Mu M, 2019, DRUG DES DEV THER, V13, P1819, DOI 10.2147/DDDT.S215949
   Mu M, 2018, DRUG DES DEV THER, V12, P4107, DOI 10.2147/DDDT.S186726
   Naowaboot J, 2016, CLIN EXP PHARMACOL P, V43, P242, DOI 10.1111/1440-1681.12514
   Narasimhan A, 2015, EUR J PHARMACOL, V761, P391, DOI 10.1016/j.ejphar.2015.04.043
   Narasimhan A, 2015, APPL PHYSIOL NUTR ME, V40, P769, DOI 10.1139/apnm-2015-0002
   Nascimento AR, 2013, OBESITY, V21, P2046, DOI 10.1002/oby.20358
   Niu CW, 2016, BIOSCI TRENDS, V10, P386, DOI 10.5582/bst.2016.01152
   Okuda H, 2019, BIOL PHARM BULL, V42, P1694, DOI 10.1248/bpb.b19-00332
   Ono K, 2005, BIOCHEM BIOPH RES CO, V336, P444, DOI 10.1016/j.bbrc.2005.08.148
   Ou L, 2003, BIOL PHARM BULL, V26, P1511, DOI 10.1248/bpb.26.1511
   Panchal SK, 2011, J CARDIOVASC PHARM, V57, P51, DOI [10.1097/FJC.0b013e3181feb90a, 10.1097/FJC.0b013e31821b1379]
   Panchal SK, 2011, J BIOMED BIOTECHNOL, DOI 10.1155/2011/351982
   Park HJ, 2018, J NAT MED-TOKYO, V72, P127, DOI 10.1007/s11418-017-1120-7
   Park HJ, 2010, EXP DERMATOL, V19, pE258, DOI 10.1111/j.1600-0625.2010.01070.x
   Patsouris D, 2006, ENDOCRINOLOGY, V147, P1508, DOI 10.1210/en.2005-1132
   Perez-Ternero C, 2017, J NUTR BIOCHEM, V48, P51, DOI 10.1016/j.jnutbio.2017.06.011
   Prakash D., 2011, J COMPLEMENT INTEGR, V8, DOI [10.2202/1553-3840.1513, DOI 10.2202/1553-3840.1513]
   Qiu Y, 2018, EBIOMEDICINE, V37, P344, DOI 10.1016/j.ebiom.2018.10.019
   Reddy JK, 2006, AM J PHYSIOL-GASTR L, V290, pG852, DOI 10.1152/ajpgi.00521.2005
   Reyad-ul Ferdous M, 2023, J BIOMOL STRUCT DYN, V41, P1704, DOI 10.1080/07391102.2021.2024255
   Reyad-ul-Ferdous Reyad-ul-Ferdous, 2015, Biology and Medicine, V7, P219
   Reyad-Ul-Ferdous M., 2014, American Journal of Life Sciences, V2, P267, DOI [DOI 10.11648/J.AJLS.20140205.13, https://doi.org/10.11648/j.ajls.20140205.13]
   Reyad-ul-ferdous M, 2020, Cardiac disease: Current approaches to gene therapy, P62, DOI DOI 10.34256/BR2017
   Reyad-Ul-Ferdous M., 2015, American Journal of BioScience, V3, P1, DOI [https://doi.org/10.11648/j.ajbio.s.2015030201.11, DOI 10.11648/J.AJBIO.S.2015030201.11]
   Reyad-ul-Ferdous M, 2022, J SAUDI CHEM SOC, V26, DOI 10.1016/j.jscs.2022.101516
   Reyad-ul-Ferdous M, 2022, J SAUDI CHEM SOC, V26, DOI 10.1016/j.jscs.2022.101454
   Rondini L, 2004, J AGR FOOD CHEM, V52, P4338, DOI 10.1021/jf0348323
   Rondini L, 2002, J AGR FOOD CHEM, V50, P3037, DOI 10.1021/jf011295i
   Sasaki K, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201900327
   Senaphan K, 2015, NUTRIENTS, V7, P6446, DOI 10.3390/nu7085283
   Seo JH, 2019, CANCER RES, V79, P6215, DOI 10.1158/0008-5472.CAN-19-1982
   Sgarbossa A, 2015, NUTRIENTS, V7, P5764, DOI 10.3390/nu7075246
   Sohn JW, 2013, TRENDS NEUROSCI, V36, P504, DOI 10.1016/j.tins.2013.05.003
   Son MJ, 2010, J CLIN BIOCHEM NUTR, V46, P150, DOI 10.3164/jcbn.09-98
   Srinivasan M, 2007, J CLIN BIOCHEM NUTR, V40, P92, DOI 10.3164/jcbn.40.92
   Sultana R, 2005, J NEUROCHEM, V92, P749, DOI 10.1111/j.1471-4159.2004.02899.x
   Suzuki A, 2007, AM J HYPERTENS, V20, P508, DOI 10.1016/j.amjhyper.2006.11.008
   Tailleux A, 2012, BBA-MOL CELL BIOL L, V1821, P809, DOI 10.1016/j.bbalip.2011.10.016
   Tsao R, 2010, NUTRIENTS, V2, P1231, DOI 10.3390/nu2121231
   Velloso LA, 2008, NEUROIMMUNOMODULAT, V15, P189, DOI 10.1159/000153423
   Wang JM, 2014, J ZHEJIANG UNIV-SC B, V15, P540, DOI 10.1631/jzus.B1300250
   Williamson G, 2005, AM J CLIN NUTR, V81, p243S, DOI 10.1093/ajcn/81.1.243S
   Xu Y, 2015, FOOD FUNCT, V6, P297, DOI 10.1039/c4fo00970c
   Yan JJ, 2001, BRIT J PHARMACOL, V133, P89, DOI 10.1038/sj.bjp.0704047
   Yao QY, 2013, TOXICOL LETT, V222, P72, DOI 10.1016/j.toxlet.2013.06.240
   Yin CL, 2019, EUR J PHARMACOL, V864, DOI 10.1016/j.ejphar.2019.172694
   Yuan JH, 2016, AM J TRANSL RES, V8, P4205
   Zhao ZH, 2003, J NUTR, V133, P1355
   Zhao ZH, 2008, FOOD CHEM, V109, P691, DOI 10.1016/j.foodchem.2008.02.039
NR 96
TC 0
Z9 0
U1 1
U2 11
PU IRANIAN SOC PHYSIOLOGY & PHARMACOLOGY
PI TEHRAN
PA PO BOX 19615-1178, TEHRAN, 00000, IRAN
SN 2476-5236
EI 2476-5244
J9 PHYSIOL PHARMACOL
JI Physiol. Pharmacol.
PD DEC
PY 2022
VL 26
IS 4
BP 345
EP 362
DI 10.52547/phypha.26.4.8
PG 18
WC Physiology
WE Emerging Sources Citation Index (ESCI)
SC Physiology
GA 7S7TI
UT WOS:000910954000001
OA gold
DA 2025-06-11
ER

PT J
AU Liang, HL
   Cheng, PW
   Lin, HL
   Hao, CL
   Ke, LY
   Chou, HY
   Tseng, YH
   Yen, HW
   Shen, KP
AF Liang, Hsin-Li
   Cheng, Pei-Wen
   Lin, Hui-Li
   Hao, Chi-Long
   Ke, Liang-Yin
   Chou, Huei-Yin
   Tseng, Yu-Hsiu
   Yen, Hsueh-Wei
   Shen, Kuo-Ping
TI Extract of pre-germinated brown rice protects against cardiovascular
   dysfunction by reducing levels of inflammation and free radicals in a
   rat model of type II diabetes
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Metabolic syndrome; Cardiovascular complications; Extract of
   pre-germinated brown rice; SHR; T2DM
ID OXIDATIVE STRESS; METABOLIC SYNDROME; SYSTEMIC INFLAMMATION;
   CARDIAC-HYPERTROPHY; GLUCOSE-METABOLISM; RECEPTOR; FIBROSIS;
   CARDIOMYOPATHY; HYPERGLYCEMIA; EXPRESSION
AB The aim of this study was to examine the effect of extract of pre-germinated brown rice (EP) on metabolic and cardiovascular dysfunction in a rat model of T2DM. Hypertensive rats were divided into: (1) normal diet (ND group), (2) induced T2DM (DM group), and T2DM rats that were treated with (3) EP30 mg/kg (EP30 group) or (4) EP300 mg/kg (EP300 group) per day for 4 weeks. T2DM symptoms included: weight loss, hyperglycaemia, hypoinsulinemia, hyperlipidaemia, higher HbA1c, glucose in urine, and lower GLP-1. EP treatment improved metabolic parameters, activated insulin signalling, and increased lipid metabolism, and also ameliorated T2DMassociated increases in levels of inflammation, free radicals, cardiac hypertrophy and fibrosis. EP reduced T2DM and related cardiovascular complications by increasing insulin signalling and lipid metabolism, and reducing levels of inflammation and free radicals. Thus, EP may be a potential candidate for the treatment of metabolic syndrome and related cardiovascular complications.
C1 [Liang, Hsin-Li] Kaohsiung Vet Gen Hosp, Dept Crit Care Med, Kaohsiung, Taiwan.
   [Cheng, Pei-Wen] Kaohsiung Vet Gen Hosp, Dept Med Educ & Res, Kaohsiung, Taiwan.
   [Cheng, Pei-Wen] Natl Sun Yat Sen Univ, Inst Biomed Sci, Kaohsiung, Taiwan.
   [Lin, Hui-Li; Ke, Liang-Yin] Kaohsiung Med Univ, Lipid Sci & Aging Res Ctr, Kaohsiung, Taiwan.
   [Hao, Chi-Long] Pingtung Christian Hosp, Dept Internal Med, Div Cardiol, Pingtung, Taiwan.
   [Ke, Liang-Yin] Kaohsiung Med Univ Hosp, Ctr Lipid Biosci, Kaohsiung, Taiwan.
   [Ke, Liang-Yin] Kaohsiung Med Univ, Dept Med Lab Sci & Biotechnol, Kaohsiung, Taiwan.
   [Chou, Huei-Yin] Meiho Univ, Dept Hlth Business Adm, Pingtung, Taiwan.
   [Tseng, Yu-Hsiu] Natl Kaohsiung Univ Hosp & Tourism, Grad Inst Food Culture & Innovat, Kaohsiung, Taiwan.
   [Yen, Hsueh-Wei] Kaohsiung Med Univ Hosp, Dept Internal Med, Div Cardiol, Kaohsiung, Taiwan.
   [Shen, Kuo-Ping] Meiho Univ, Dept Nursing, 23 Ping Kuang Rd, Pingtung 91202, Taiwan.
C3 Kaohsiung Veterans General Hospital; Kaohsiung Veterans General
   Hospital; National Sun Yat Sen University; Kaohsiung Medical University;
   Kaohsiung Medical University; Kaohsiung Medical University Hospital;
   Kaohsiung Medical University; National Kaohsiung University of
   Hospitality & Tourism; Kaohsiung Medical University; Kaohsiung Medical
   University Hospital
RP Shen, KP (corresponding author), Meiho Univ, Dept Nursing, 23 Ping Kuang Rd, Pingtung 91202, Taiwan.
EM x00002148@meiho.edu.tw
RI Ke, Liang-Yin/A-2778-2009
FU Pingtung Christian Hospital, Pingtung, Taiwan [108-FI-DBS-IAC-R-001,
   107-FI-DBS-IAC-R-001]; Kaohsiung Veterans General Hosptial, Kaohsiung,
   Taiwan [MOST 105-2320-B-276-003-MY2, MOST 108-2320-B-276-002-MY3];
   Kaohsiung Veterans General Hospital [VGHMHU109-001]
FX This work was supported by grants from Pingtung Christian Hospital,
   Pingtung, Taiwan awarded to Dr. Kuo-Ping Shen (108-FI-DBS-IAC-R-001 and
   107-FI-DBS-IAC-R-001), and from the Kaohsiung Veterans General Hosptial,
   Kaohsiung, Taiwan, to Dr. Hui-Li Lin (MOST 105-2320-B-276-003-MY2) and
   to Dr. Kuo-Ping Shen (MOST 108-2320-B-276-002-MY3), as well as from
   Kaohsiung Veterans General Hospital to Dr. Kuo-Ping Shen
   (VGHMHU109-001). We would also like to thank Miss Tsui-Jung Lin for her
   technical advice and support.
CR Abbasi A, 2017, CELL MOL BIOL, V63, P89, DOI 10.14715/cmb/2017.63.7.15
   Akhtar S, 2013, BIOIMPACTS, V3, P5, DOI 10.5681/bi.2013.008
   Anson NM, 2011, J NUTR, V141, P137, DOI 10.3945/jn.110.127720
   Aroor AR, 2013, METABOLISM, V62, P1543, DOI 10.1016/j.metabol.2013.07.001
   Barrett EM, 2019, BRIT J NUTR, V121, P914, DOI 10.1017/S000711451900031X
   Briançon-Marjollet A, 2016, J PHYSIOL-LONDON, V594, P1727, DOI 10.1113/JP271321
   Calligaris SD, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0060931
   Chen FC, 2018, KAOHSIUNG J MED SCI, V34, P14, DOI 10.1016/j.kjms.2017.08.009
   Chen SJ, 2016, J SCI FOOD AGR, V96, P1772, DOI 10.1002/jsfa.7284
   Chen X, 2016, J INTERF CYTOK RES, V36, P580, DOI 10.1089/jir.2016.0022
   Chen YF, 2016, J NUTR BIOCHEM, V31, P98, DOI 10.1016/j.jnutbio.2015.12.020
   Cheng M, 2016, CELL PHYSIOL BIOCHEM, V38, P1928, DOI 10.1159/000445554
   Simao ANC, 2015, METAB BRAIN DIS, V30, P1409, DOI 10.1007/s11011-015-9720-y
   Colagiuri S, 2010, DIABETES OBES METAB, V12, P463, DOI 10.1111/j.1463-1326.2009.01182.x
   Costantini D, 2010, J ANIM PHYSIOL AN N, V94, P24, DOI 10.1111/j.1439-0396.2008.00880.x
   Cutler DA, 2019, FOOD SCI NUTR, V7, P1426, DOI 10.1002/fsn3.977
   Dludla PV, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010023
   Ebaid H, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/2835152
   Fang L, 2017, AM J TRANSL RES, V9, P5063
   Giusti L, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/1026268
   Goufo P, 2014, FOOD SCI NUTR, V2, P75, DOI 10.1002/fsn3.86
   Grandl G, 2018, SEMIN IMMUNOPATHOL, V40, P215, DOI 10.1007/s00281-017-0666-5
   Guerci B, 2001, DIABETES METAB, V27, P425
   Hao CL, 2019, J FOOD BIOCHEM, V43, DOI 10.1111/jfbc.12769
   Hong MY, 2015, J NUTR, V145, P939, DOI 10.3945/jn.114.206607
   Hsu WH, 2013, FOOD FUNCT, V4, P1742, DOI 10.1039/c3fo60268k
   Jeong MH, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0136236
   Kavishankar GB, 2014, PHYTOMEDICINE, V21, P1026, DOI 10.1016/j.phymed.2014.04.033
   Kern L, 2019, CANCERS, V11, DOI 10.3390/cancers11010024
   Kho MC, 2016, NUTRIENTS, V8, DOI 10.3390/nu8060369
   Kimura T, 2019, INT HEART J, V60, P728, DOI 10.1536/ihj.18-392
   Kobayashi S, 2017, BIOL PHARM BULL, V40, P2061, DOI 10.1248/bpb.b17-00210
   Koitabashi N, 2007, HYPERTENSION, V49, P1120, DOI 10.1161/HYPERTENSIONAHA.106.077537
   Lai CH, 2016, INT J MED SCI, V13, P277, DOI 10.7150/ijms.14769
   Lattimer JM, 2010, NUTRIENTS, V2, P1266, DOI 10.3390/nu2121266
   Liang Yu-Chia, 2017, Biomedicine (Taipei), V7, P18, DOI 10.1051/bmdcn/2017070318
   Lin HL, 2020, J FOOD BIOCHEM, V44, DOI 10.1111/jfbc.13129
   Liu Q, 2014, J DIABETES INVEST, V5, P623, DOI 10.1111/jdi.12250
   Meschiari CA, 2017, GEROSCIENCE, V39, P7, DOI 10.1007/s11357-017-9959-9
   Nakayama A, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0137106
   Noratto G, 2015, J NUTR BIOCHEM, V26, P633, DOI 10.1016/j.jnutbio.2014.12.014
   Qu LL, 2019, FOOD CHEM TOXICOL, V125, P85, DOI 10.1016/j.fct.2018.12.046
   Rameshrad M, 2019, PHYTOTHER RES, V33, P832, DOI 10.1002/ptr.6276
   Ramu R, 2016, FOOD FUNCT, V7, P3999, DOI [10.1039/C6FO00343E, 10.1039/c6fo00343e]
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   Reed MJ, 2000, METABOLISM, V49, P1390, DOI 10.1053/meta.2000.17721
   Shao XR, 2016, CURR STEM CELL RES T, V11, P282, DOI 10.2174/1574888X10666150528144905
   Shen KP, 2016, J CLIN BIOCHEM NUTR, V59, P39, DOI 10.3164/jcbn.15-117
   Shen KP, 2015, J CLIN BIOCHEM NUTR, V56, P28, DOI 10.3164/jcbn.14-50
   Sikder K, 2018, CELL PHYSIOL BIOCHEM, V48, P1317, DOI 10.1159/000492091
   Srinivasan K, 2005, PHARMACOL RES, V52, P313, DOI 10.1016/j.phrs.2005.05.004
   Tovar AR, 2002, J NUTR, V132, P2562, DOI 10.1093/jn/132.9.2562
   Udomkasemsab A, 2018, BMC COMPLEM ALTERN M, V18, DOI 10.1186/s12906-018-2400-9
   Wang XT, 2018, BIOMED PHARMACOTHER, V97, P1461, DOI 10.1016/j.biopha.2017.11.032
   Wang ZY, 2019, TRENDS CANCER, V5, P30, DOI 10.1016/j.trecan.2018.11.003
   Wróblewski A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081872
   Yadav HN, 2010, MOL CELL BIOCHEM, V343, P75, DOI 10.1007/s11010-010-0500-z
   Yanagihara H, 2016, J PHARMACOL SCI, V131, P190, DOI 10.1016/j.jphs.2016.06.003
   Yen HW, 2017, BIOSCI BIOTECH BIOCH, V81, P979, DOI 10.1080/09168451.2017.1279848
   Zanetti M, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20030499
   Zayed EA, 2018, J BIOCHEM MOL TOXIC, V32, DOI 10.1002/jbt.22218
NR 61
TC 7
Z9 9
U1 0
U2 18
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD DEC
PY 2020
VL 75
AR 104218
DI 10.1016/j.jff.2020.104218
PG 12
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA PH4DG
UT WOS:000600364900015
OA gold
DA 2025-06-11
ER

PT J
AU Lee, WC
   Wu, KLH
   Leu, S
   Tain, YL
AF Lee, Wei-Chia
   Wu, Kay L. H.
   Leu, Steve
   Tain, You-Lin
TI Translational insights on developmental origins of metabolic syndrome:
   Focus on fructose consumption
SO BIOMEDICAL JOURNAL
LA English
DT Review
DE Developmental origins of health and disease (DOHaD); Fructose;
   Hypertension; Metabolic syndrome; Obesity
ID PROGRAMMED HYPERTENSION; INDUCED DYSLIPIDEMIA; OXIDATIVE STRESS; HUMAN
   PLACENTA; KIDNEY INJURY; CORN SYRUP; LATER LIFE; RAT; EXPOSURE; BLADDER
AB Metabolic syndrome (MetS) is a highly prevalent complex trait despite recent advances in pathophysiology and pharmacological treatment. MetS can begin in early life by so-called the developmental origins of health and disease (DOHaD). The DOHaD concept offers a novel approach to prevent MetS through reprogramming. High fructose (HF) intake has been associated with increased risk of MetS. HF diet becomes one of the most commonly used animal model to induce MetS. This review discusses the maternal HF diet induced programming process and reprogramming strategy to prevent MetS of developmental origin, with an emphasis on: (1) an overview of metabolic effects of fructose consumption on MetS; (2) insight from maternal HF animal models on MetS-related phenotypes; (3) impact of HF consumption induces organ-specific transcriptome changes; and (4) application of reprogramming strategy to prevent maternal HF consumption-induced MetS. Research into the preventions and treatments of MetS that begin early in life will have a lifelong impact and profound savings in disease burden and financial costs.
C1 [Lee, Wei-Chia] Kaohsiung Chang Gung Mem Hosp, Dept Urol, Kaohsiung, Taiwan.
   [Wu, Kay L. H.; Leu, Steve; Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung, Taiwan.
   [Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Dept Pediat, 123 Dabi Rd, Kaohsiung 833, Taiwan.
   [Lee, Wei-Chia; Wu, Kay L. H.; Leu, Steve; Tain, You-Lin] Chang Gung Univ, Coll Med, Taoyuan, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung Memorial Hospital; Chang Gung
   Memorial Hospital; Chang Gung University
RP Tain, YL (corresponding author), Kaohsiung Chang Gung Mem Hosp, Dept Pediat, 123 Dabi Rd, Kaohsiung 833, Taiwan.
EM tainyl@hotmail.com
RI Tain, You-Lin/H-2827-2019; Wu, Kay/ACD-1767-2022; Leu, Steve/D-6807-2011
OI Wu, Kay L.H./0000-0002-7297-6788; Tain, You-Lin/0000-0002-7059-6407;
   Lee, Wei-Chia/0000-0003-0701-2285
FU Chang Gung Medical Foundation [CMRPG8F0022, CMRPG8G0191, CGMPG8F0031,
   CGMPG8F0032]; Ministry of Science and Technology of the Republic of
   China, Taiwan [MOST 106-2314-B182A-100]
FX This work was supported by CMRPG8F0022 and CMRPG8G0191 (Y.L.T.), and
   CGMPG8F0031 and CGMPG8F0032 (J.Y.H.C.) from the Chang Gung Medical
   Foundation, and MOST 106-2314-B182A-100 (W.C.L.) from the Ministry of
   Science and Technology of the Republic of China, Taiwan.
CR Alzamendi A, 2010, ENDOCRINOLOGY, V151, P4214, DOI 10.1210/en.2009-1353
   Azhar S, 2010, FUTUR CARDIOL, V6, P657, DOI [10.2217/fca.10.86, 10.2217/FCA.10.86]
   Bray GA, 2004, AM J CLIN NUTR, V79, P537
   Bruce KD, 2010, J NUTR, V140, P648, DOI 10.3945/jn.109.111179
   Chao Yung-Mei, 2016, Shengli Xuebao, V68, P557, DOI 10.13294/j.aps.2016.0064
   Ching RHH, 2011, J NUTR, V141, P1664, DOI 10.3945/jn.111.142299
   DAI S, 1995, J PHARMACOL TOX MET, V33, P101, DOI 10.1016/1056-8719(94)00063-A
   Danaei G, 2011, LANCET, V378, P31, DOI 10.1016/S0140-6736(11)60679-X
   Correia MLD, 2012, J HUM HYPERTENS, V26, P405, DOI 10.1038/jhh.2011.61
   Goran MI, 2013, NAT REV ENDOCRINOL, V9, P494, DOI 10.1038/nrendo.2013.108
   Gray C, 2016, BRIT J NUTR, V115, P594, DOI 10.1017/S0007114515004936
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   HAGERMAN DD, 1959, J PHYSIOL-LONDON, V146, P98, DOI 10.1113/jphysiol.1959.sp006180
   HOLMBERG NG, 1956, ACTA PHYSIOL SCAND, V36, P291, DOI 10.1111/j.1748-1716.1956.tb01326.x
   Hsu CN, 2016, FRONT PHYSIOL, V7, DOI 10.3389/fphys.2016.00299
   Hsu CN, 2015, J RENIN-ANGIO-ALDO S, V16, P506, DOI 10.1177/1470320313514123
   Imig JD, 2015, HYPERTENSION, V65, P476, DOI 10.1161/HYPERTENSIONAHA.114.03585
   Johnson RJ, 2007, AM J CLIN NUTR, V86, P899
   Kelishadi R, 2014, NUTRITION, V30, P503, DOI 10.1016/j.nut.2013.08.014
   Klein AV, 2015, J HYPERTENS, V33, P912, DOI 10.1097/HJH.0000000000000551
   Lee WC, 2008, J UROLOGY, V179, P2470, DOI 10.1016/j.juro.2008.01.086
   Lee WC, 2016, SCI REP-UK, V6, DOI 10.1038/srep34669
   Lineker C, 2016, REPROD FERT DEVELOP, V28, P2007, DOI 10.1071/RD15119
   McMillen IC, 2005, PHYSIOL REV, V85, P571, DOI 10.1152/physrev.00053.2003
   Monsalve FA, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/549627
   Regnault TRH, 2013, CLIN EXP PHARMACOL P, V40, P824, DOI 10.1111/1440-1681.12162
   Rodríguez L, 2016, J NUTR BIOCHEM, V32, P115, DOI 10.1016/j.jnutbio.2016.02.013
   Rodríguez L, 2015, J NUTR METAB, V2015, DOI 10.1155/2015/158091
   Saad AF, 2016, AM J OBSTET GYNECOL, V215, DOI 10.1016/j.ajog.2016.03.038
   Sherman RC, 2000, CLIN SCI, V98, P269, DOI 10.1042/CS19990275
   Sloboda DM, 2014, J OBES, V2014, DOI 10.1155/2014/203474
   Tain YL, 2015, NUTR METAB CARDIOVAS, V25, P1146, DOI 10.1016/j.numecd.2015.08.002
   Tain YL, 2015, INT J MOL SCI, V17, pE20
   Tain YL, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18040841
   Tain YL, 2016, NUTRIENTS, V8, DOI 10.3390/nu8120757
   Tain YL, 2016, J NUTR BIOCHEM, V38, P86, DOI 10.1016/j.jnutbio.2016.08.006
   Tain YL, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17010023
   Tain YL, 2015, J NUTR BIOCHEM, V26, P642, DOI 10.1016/j.jnutbio.2014.12.017
   Tain YL, 2014, INT J MOL SCI, V15, P18484, DOI 10.3390/ijms151018484
   Tain YL, 2014, J PINEAL RES, V57, P80, DOI 10.1111/jpi.12145
   Tappy L, 2010, PHYSIOL REV, V90, P23, DOI 10.1152/physrev.00019.2009
   Tong YC, 2007, J UROLOGY, V178, P1537, DOI 10.1016/j.juro.2007.05.114
   Toop CR, 2017, J PHYSIOL-LONDON, V595, P4379, DOI 10.1113/JP274066
   Toop CR, 2016, NUTRIENTS, V8, DOI 10.3390/nu8090577
   Tran LT, 2009, MOL CELL BIOCHEM, V332, P145, DOI 10.1007/s11010-009-0184-4
   Yamada-Obara N, 2016, CLIN EXP NEPHROL, V20, P853, DOI 10.1007/s10157-016-1265-9
   Zhang DM, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040335
NR 47
TC 36
Z9 38
U1 0
U2 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2319-4170
EI 2320-2890
J9 BIOMED J
JI Biomed. J.
PD APR
PY 2018
VL 41
IS 2
BP 96
EP 101
DI 10.1016/j.bj.2018.02.006
PG 6
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine
GA GI3FT
UT WOS:000434257700004
PM 29866605
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Van der Schueren, B
   Vangoitsenhoven, R
   Geeraert, B
   De Keyzer, D
   Hulsmans, M
   Lannoo, M
   Huber, HJ
   Mathieu, C
   Holvoet, P
AF Van der Schueren, B.
   Vangoitsenhoven, R.
   Geeraert, B.
   De Keyzer, D.
   Hulsmans, M.
   Lannoo, M.
   Huber, H. J.
   Mathieu, C.
   Holvoet, P.
TI Low cytochrome oxidase 4I1 links mitochondrial dysfunction to obesity
   and type 2 diabetes in humans and mice
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID CIRCULATING OXIDIZED LDL; LOW-DENSITY-LIPOPROTEIN; METABOLIC SYNDROME;
   OXIDATIVE STRESS; C-OXIDASE; MYOCARDIAL-INFARCTION; INSULIN SENSITIVITY;
   CARDIOVASCULAR-DISEASE; WEIGHT-LOSS; RISK
AB OBJECTIVES: Cytochrome oxidase (COX) dysfunction is associated with mitochondrial oxidative stress. We determined the association between COX expression, obesity and type 2 diabetes.
   SUBJECTS/METHODS: COX4I1 and COX10 genes were measured in monocytes of 24 lean controls, 31 glucose-tolerant and 67 diabetic obese patients, and 17 morbidly obese patients before and after bariatric surgery. We investigated the effect of caloric restriction and peroxisome proliferator-activated receptor (PPAR) agonist treatment on Cox in obese diabetic mice, and that of diet-induced insulin resistance in Streptozotocin-treated mice.
   RESULTS: Low COX4I1 was associated with type 2 diabetes in obese patients, adjusting for age, gender, smoking, interleukin-6 and high-sensitivity C-reactive protein, all related to metabolic syndrome (MetS; odds ratio: 6.1, 95% confidence interval: 2.3-16). In contrast, COX10 was low in glucose-tolerant and diabetic obese patients. In morbidly obese patients, COX4I1 was lower in visceral adipose tissue collected at bariatric surgery. In their monocytes, COX4I1 decreased after bariatric surgery, and low COX4I1 at 4 months was associated with MetS at 7 years. In leptin-deficient obese diabetic mice, Cox4i1 was low in white visceral adipose tissue (n = 13; P < 0.001) compared with age-matched lean mice (n = 10). PPAR.-agonist treatment (n = 13), but not caloric restriction (n = 11), increased Cox4i1 (P < 0.001). Increase in Cox4i1 depended on the increase in glucose transporter 4 (Glut4) expression and insulin sensitivity, independent of the increase in blood adiponectin. In streptozotocin-treated mice (three groups of seven mice, diet-induced insulin resistance decreased Cox4i1 and Glut4 (P < 0.001 for both).
   CONCLUSION: COX4I1 depression is related to insulin resistance and type 2 diabetes in obesity. In peripheral blood monocytes, it may be a diagnostically useful biomarker.
C1 [Van der Schueren, B.; Vangoitsenhoven, R.; Lannoo, M.; Mathieu, C.] Katholieke Univ Leuven, Lab Clin & Expt Med & Endocrinol, B-3000 Leuven, Belgium.
   [Geeraert, B.; De Keyzer, D.; Hulsmans, M.; Huber, H. J.; Holvoet, P.] Katholieke Univ Leuven, Dept Cardiovasc Sci, Div Atherosclerosis & Metab, B-3000 Leuven, Belgium.
C3 KU Leuven; KU Leuven
RP Holvoet, P (corresponding author), Katholieke Univ Leuven, Dept Cardiovasc Sci, Div Atherosclerosis & Metab, Herestr 49,O&N1, B-3000 Leuven, Belgium.
EM paul.holvoet@med.kuleuven.be
RI Hulsmans, Maarten/AAI-9547-2020; Vangoitsenhoven, Roman/B-3196-2018;
   lannoo, matthias/AAB-1706-2020; mathieu, chantal/ABD-5505-2021; HOLVOET,
   PAUL/T-8434-2017
OI Mathieu, Chantal/0000-0002-4055-5233; Holvoet, Paul/0000-0001-9201-0772;
   Van der Schueren, Bart/0000-0003-4754-784X; Lannoo,
   matthias/0000-0001-7815-1157; Hulsmans, Maarten/0000-0003-1009-658X;
   Vangoitsenhoven, Roman/0000-0003-3523-669X
FU Bijzonder Onderzoeksfonds of the KU Leuven [PF/10/014];
   Interdisciplinair Ontwikkelingsfonds-Kennisplatform [KP/12/009]; Fonds
   voor Wetenschappelijk Onderzoek-Vlaanderen [G0846.11]
FX We thank Roxane Menten for her excellent technical support. This work
   was funded by the Bijzonder Onderzoeksfonds of the KU Leuven (PF/10/014;
   Center of Excellence), by the Interdisciplinair
   Ontwikkelingsfonds-Kennisplatform (KP/12/009) and by the Fonds voor
   Wetenschappelijk Onderzoek-Vlaanderen (G0846.11 and Vascular Biology
   Network). MH is a postdoctoral fellow of the Fonds voor Wetenschappelijk
   Onderzoek-Vlaanderen.
CR Anderson EJ, 2009, J CLIN INVEST, V119, P573, DOI 10.1172/JCI37048
   Antonopoulos AS, 2014, DIABETES
   Arnold S, 2012, ADV EXP MED BIOL, V748, P305, DOI 10.1007/978-1-4614-3573-0_13
   Arnold S, 2012, MITOCHONDRION, V12, P46, DOI 10.1016/j.mito.2011.05.003
   Bonnard C, 2008, J CLIN INVEST, V118, P789, DOI 10.1172/JCI32601
   Burkart EM, 2007, J CLIN INVEST, V117, P3930, DOI 10.1172/JCI32578
   Cummings David E., 2004, Journal of Clinical Endocrinology & Metabolism, V89, P2608, DOI 10.1210/jc.2004-0433
   Cynis H, 2013, INT J EXP PATHOL, V94, P217, DOI 10.1111/iep.12020
   FRIDOVICH I, 1989, J BIOL CHEM, V264, P7761
   Fujii M, 2013, MED MOL MORPHOL, V46, P141, DOI 10.1007/s00795-013-0016-1
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Geeraert B, 2007, J THROMB HAEMOST, V5, P2529, DOI 10.1111/j.1538-7836.2007.02786.x
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Grundy SM, 2004, J CLIN ENDOCR METAB, V89, P2595, DOI 10.1210/jc.2004-0372
   Holvoet P, 1998, CIRCULATION, V98, P1487, DOI 10.1161/01.CIR.98.15.1487
   Holvoet P, 2004, DIABETES, V53, P1068, DOI 10.2337/diabetes.53.4.1068
   Holvoet P, 2003, ARTERIOSCL THROM VAS, V23, P1444, DOI 10.1161/01.ATV.0000080379.05071.22
   Holvoet P, 2001, ARTERIOSCL THROM VAS, V21, P844, DOI 10.1161/01.ATV.21.5.844
   Holvoet P, 2008, JAMA-J AM MED ASSOC, V299, P2287, DOI 10.1001/jama.299.19.2287
   Hulsmans M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0062253
   Hulsmans M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030414
   Hulsmans M, 2011, FASEB J, V25, P2515, DOI 10.1096/fj.11-181149
   Kadenbach B, 2009, TRENDS MOL MED, V15, P139, DOI 10.1016/j.molmed.2009.02.004
   Klein S, 2004, CIRCULATION, V110, P2952, DOI 10.1161/01.CIR.0000145546.97738.1E
   Liu Y, 2015, DIABETES, V64, P36, DOI 10.2337/db14-0267
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   Luo M, 2013, J CLIN INVEST, V123, P1262, DOI 10.1172/JCI65268
   Mertens A, 2003, CIRCULATION, V107, P1640, DOI 10.1161/01.CIR.0000056523.08033.9F
   Muntner P, 2004, ANN EPIDEMIOL, V14, P686, DOI 10.1016/j.annepidem.2004.01.002
   Njajou OT, 2009, DIABETES-METAB RES, V25, P733, DOI 10.1002/dmrr.1011
   Park K, 2009, DIABETES CARE, V32, P1302, DOI 10.2337/dc09-0259
   Pickl WF, 1996, J IMMUNOL, V157, P3850
   Poyton RO, 1996, ANNU REV BIOCHEM, V65, P563, DOI 10.1146/annurev.bi.65.070196.003023
   Reilly MP, 2005, CIRCULATION, V111, P932, DOI 10.1161/01.CIR.0000155620.10387.43
   Ridderstråle M, 2002, DIABETES, V51, P3554, DOI 10.2337/diabetes.51.12.3554
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   Ridker PM, 2000, CIRCULATION, V101, P1767, DOI 10.1161/01.CIR.101.15.1767
   Rindler PM, 2013, AM J PHYSIOL-HEART C, V305, pH634, DOI 10.1152/ajpheart.00799.2012
   Salio M, 2000, EUR J IMMUNOL, V30, P705, DOI 10.1002/1521-4141(200002)30:2<705::AID-IMMU705>3.0.CO;2-P
   Sjöström L, 2004, NEW ENGL J MED, V351, P2683, DOI 10.1056/NEJMoa035622
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Vandesompele J, 2002, GENOME BIOL, V3, DOI 10.1186/gb-2002-3-7-research0034
   Verreth W, 2004, CIRCULATION, V110, P3259, DOI 10.1161/01.CIR.0000147614.85888.7A
   Villani G, 1997, P NATL ACAD SCI USA, V94, P1166, DOI 10.1073/pnas.94.4.1166
   Wallace DC, 2005, ANNU REV GENET, V39, P359, DOI 10.1146/annurev.genet.39.110304.095751
   Wang CH, 2013, FEBS J, V280, P1039, DOI 10.1111/febs.12096
   Williams SL, 2004, J BIOL CHEM, V279, P7462, DOI 10.1074/jbc.M309232200
NR 47
TC 24
Z9 29
U1 0
U2 12
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD AUG
PY 2015
VL 39
IS 8
BP 1254
EP 1263
DI 10.1038/ijo.2015.58
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA CR0BK
UT WOS:000360983000012
PM 25869607
DA 2025-06-11
ER

PT J
AU Huang, YH
   Tain, YL
   Hsu, CN
AF Huang, Ying-Hua
   Tain, You-Lin
   Hsu, Chien-Ning
TI Maternal Supplementation of Probiotics, Prebiotics or Postbiotics to
   Prevent Offspring Metabolic Syndrome: The Gap between Preclinical
   Results and Clinical Translation
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE obesity; hypertension; metabolic syndrome; hyperlipidemia; probiotics;
   prebiotics; postbiotics; developmental origins of health and disease
   (DOHaD)
ID HIGH-FAT DIET; LOW-BIRTH-WEIGHT; INDUCED PROGRAMMED HYPERTENSION;
   INCREASES BLOOD-PRESSURE; REDUCES NEPHRON NUMBER; IN-UTERO EXPOSURE; GUT
   MICROBIOTA; DEVELOPMENTAL ORIGINS; OXIDATIVE STRESS; NITRIC-OXIDE
AB Metabolic syndrome (MetS) is an extremely prevalent complex trait and it can originate in early life. This concept is now being termed the developmental origins of health and disease (DOHaD). Increasing evidence supports that disturbance of gut microbiota influences various risk factors of MetS. The DOHaD theory provides an innovative strategy to prevent MetS through early intervention (i.e., reprogramming). In this review, we summarize the existing literature that supports how environmental cues induced MetS of developmental origins and the interplay between gut microbiota and other fundamental underlying mechanisms. We also present an overview of experimental animal models addressing implementation of gut microbiota-targeted reprogramming interventions to avert the programming of MetS. Even with growing evidence from animal studies supporting the uses of gut microbiota-targeted therapies start before birth to protect against MetS of developmental origins, their effects on pregnant women are still unknown and these results require further clinical translation.
C1 [Huang, Ying-Hua; Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Kaohsiung 833, Taiwan.
   [Tain, You-Lin] Chang Gung Univ, Coll Med, Taoyuan 333, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Med Univ, Sch Pharm, Kaohsiung 807, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital; Kaohsiung Medical University
RP Hsu, CN (corresponding author), Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan.; Hsu, CN (corresponding author), Kaohsiung Med Univ, Sch Pharm, Kaohsiung 807, Taiwan.
EM crihsu@cgmh.org.tw
RI Hsu, Chien-Ning/GLS-4014-2022; Tain, You-Lin/H-2827-2019
OI Hsu, Chien-Ning/0000-0001-7470-528X; , Ying-Hua/0000-0003-0430-9745;
   Tain, You-Lin/0000-0002-7059-6407
FU Chang Gung Memorial Hospital, Kaohsiung, Taiwan [CORPG8M0151,
   CORPG8M0081, CMRPG8L1221, CORPG8L0301, CMRPG8L0961, CMRPG8M0751]
FX This research was funded by Chang Gung Memorial Hospital, Kaohsiung,
   Taiwan, grants CORPG8M0151, CORPG8M0081, CMRPG8L1221, CORPG8L0301,
   CMRPG8L0961, and CMRPG8M0751.
CR Agus A, 2018, CELL HOST MICROBE, V23, P716, DOI 10.1016/j.chom.2018.05.003
   Arango LFG, 2015, CURR DIABETES REP, V15, DOI 10.1007/s11892-014-0567-0
   Arentson-Lantz EJ, 2014, NUTR RES, V34, P241, DOI 10.1016/j.nutres.2014.01.001
   Armitage JA, 2004, J PHYSIOL-LONDON, V561, P355, DOI 10.1113/jphysiol.2004.072009
   Arrieta MC, 2014, FRONT IMMUNOL, V5, DOI 10.3389/fimmu.2014.00427
   Asgharian H, 2020, EUR J NUTR, V59, P205, DOI 10.1007/s00394-019-01900-1
   Barengolts E, 2016, ENDOCR PRACT, V22, P1224, DOI 10.4158/EP151157.RA
   Bergel E, 2002, BJOG-INT J OBSTET GY, V109, P540
   Bessa ASM, 2019, HYPERTENS RES, V42, P1883, DOI 10.1038/s41440-019-0321-8
   Bo S, 2001, EXP CLIN ENDOCR DIAB, V109, P135, DOI 10.1055/s-2001-14835
   Boney CM, 2005, PEDIATRICS, V115, pE290, DOI 10.1542/peds.2004-1808
   Brantsæter AL, 2011, AM J EPIDEMIOL, V174, P807, DOI 10.1093/aje/kwr168
   Bruce EB, 2018, EXP GERONTOL, V111, P133, DOI 10.1016/j.exger.2018.07.008
   Buckley JD, 2010, NUTRIENTS, V2, P1212, DOI 10.3390/nu2121212
   Buettner R, 2007, OBESITY, V15, P798, DOI 10.1038/oby.2007.608
   Campbell EL, 2019, NAT REV GASTRO HEPAT, V16, P106, DOI 10.1038/s41575-018-0079-5
   Canfora EE, 2015, NAT REV ENDOCRINOL, V11, P577, DOI 10.1038/nrendo.2015.128
   Cao X, 2022, ELIFE, V11, DOI [10.7554/eLife.72266, 10.7554/eLife.72266.sa0, 10.7554/eLife.72266.sa1, 10.7554/eLife.72266.sa2]
   Care AS, 2016, HYPERTENSION, V67, P1038, DOI 10.1161/HYPERTENSIONAHA.115.06793
   Chang HY, 2016, STEROIDS, V108, P1, DOI 10.1016/j.steroids.2016.02.017
   Chao Yung-Mei, 2016, Shengli Xuebao, V68, P557, DOI 10.13294/j.aps.2016.0064
   Chen HE, 2019, J NUTR BIOCHEM, V70, P28, DOI 10.1016/j.jnutbio.2019.04.002
   Ching RHH, 2011, J NUTR, V141, P1664, DOI 10.3945/jn.111.142299
   ClinicalTrials.gov, 2022, CLINICALTRIALS
   Cottrell EC, 2009, FRONT BEHAV NEUROSCI, V3, DOI 10.3389/neuro.08.019.2009
   Croci S, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051389
   Cuinat C, 2022, CURR NUTR REP, V11, P537, DOI 10.1007/s13668-022-00429-w
   Dabke K, 2019, J CLIN INVEST, V129, P4050, DOI 10.1172/JCI129194
   Correia MLD, 2012, J HUM HYPERTENS, V26, P405, DOI 10.1038/jhh.2011.61
   Guimaraes KSD, 2020, FOOD FUNCT, V11, P8939, DOI [10.1039/d0fo01718c, 10.1039/D0FO01718C]
   de Oliveira Y, 2020, FOOD FUNCT, V11, P5581, DOI [10.1039/d0fo00514b, 10.1039/D0FO00514B]
   Duan RQ, 2021, J AGR FOOD CHEM, V69, P7629, DOI 10.1021/acs.jafc.1c01813
   Efeyan A, 2015, NATURE, V517, P302, DOI 10.1038/nature14190
   FAO/WHO, 2002, FOOD AGR ORG UN WHO, V21
   Ferreira DS, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038795
   Fraser A, 2010, CIRCULATION, V121, P2557, DOI 10.1161/CIRCULATIONAHA.109.906081
   Galyon KD, 2017, AM J OBSTET GYNECOL, V216, DOI 10.1016/j.ajog.2016.08.041
   Gambling L, 2003, J PHYSIOL-LONDON, V552, P603, DOI 10.1113/jphysiol.2003.051383
   Gao Z., 2022, ENDOTHELIAL PROHIBIT
   Gardner DS, 2005, AM J PHYSIOL-REG I, V289, pR947, DOI 10.1152/ajpregu.00120.2005
   Gibson GR, 2017, NAT REV GASTRO HEPAT, V14, P491, DOI 10.1038/nrgastro.2017.75
   Gray C, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0115994
   Gray SP, 2010, J AM SOC NEPHROL, V21, P1891, DOI 10.1681/ASN.2010040368
   Groer MW, 2014, MICROBIOME, V2, DOI 10.1186/2049-2618-2-38
   Guo YJ, 2018, FOOD FUNCT, V9, P4317, DOI 10.1039/c8fo00444g
   Halkjær SI, 2020, CURR DEV NUTR, V4, DOI 10.1093/cdn/nzaa095
   Haugen AC, 2015, J DEV ORIG HLTH DIS, V6, P55, DOI 10.1017/S2040174414000580
   Havel PJ, 2005, NUTR REV, V63, P133, DOI [10.1301/nr.2005.may.133-157, 10.1111/j.1753-4887.2005.tb00132.x]
   Holloway AC, 2005, DIABETOLOGIA, V48, P2661, DOI 10.1007/s00125-005-0022-5
   Hrudey EJ, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0133313
   Hsu CN, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23147924
   Hsu CN, 2022, J NUTR BIOCHEM, V108, DOI 10.1016/j.jnutbio.2022.109090
   Hsu CN, 2022, NUTRIENTS, V14, DOI 10.3390/nu14051031
   Hsu CN, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222111872
   Hsu CN, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.745716
   Hsu CN, 2021, NUTRIENTS, V13, DOI 10.3390/nu13093041
   Hsu CN, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10091393
   Hsu CN, 2021, NUTRIENTS, V13, DOI 10.3390/nu13072290
   Hsu CN, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9060623
   Hsu CN, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22084210
   Hsu CN, 2021, J NUTR BIOCHEM, V93, DOI 10.1016/j.jnutbio.2021.108630
   Hsu CN, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22052674
   Hsu CN, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22052298
   Hsu CN, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10020247
   Hsu CN, 2021, MOL NUTR FOOD RES, V65, DOI 10.1002/mnfr.202001116
   Hsu CN, 2020, BIOMEDICINES, V8, DOI 10.3390/biomedicines8120567
   Hsu CN, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21228705
   Hsu CN, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21197237
   Hsu CN, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21155488
   Hsu CN, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122908
   Hsu CN, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20184382
   Hsu CN, 2019, NUTRIENTS, V11, DOI 10.3390/nu11091982
   Hsu CN, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201900073
   Hsu CN, 2018, NUTRIENTS, V10, DOI 10.3390/nu10091229
   Hsu MH, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21103428
   Huang LT, 2012, INT J MOL SCI, V13, P14606, DOI 10.3390/ijms131114606
   Hult M, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013582
   Iqbal W, 2013, AM J OBSTET GYNECOL, V209, DOI 10.1016/j.ajog.2013.08.027
   Ito J, 2016, LIFE SCI, V151, P70, DOI 10.1016/j.lfs.2016.02.089
   Jansson T, 2013, CLIN OBSTET GYNECOL, V56, P591, DOI 10.1097/GRF.0b013e3182993a2e
   Jaworska K, 2021, AM J PHYSIOL-GASTR L, V321, pG355, DOI 10.1152/ajpgi.00099.2021
   Jaworska K, 2019, TOXINS, V11, DOI 10.3390/toxins11090490
   Jia XK, 2021, FRONT CELL INFECT MI, V11, DOI 10.3389/fcimb.2021.634780
   Jinno S, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030196
   Joe B, 2020, HYPERTENSION, V76, P1847, DOI 10.1161/HYPERTENSIONAHA.120.15939
   Jones AM, 2021, MED SCI SPORT EXER, V53, P280, DOI 10.1249/MSS.0000000000002470
   Kawabe Y, 2019, AM J PHYSIOL-ENDOC M, V317, pE1140, DOI 10.1152/ajpendo.00311.2019
   Kelishadi R, 2015, PAEDIATR INT CHILD H, V35, P110, DOI 10.1179/2046905514Y.0000000136
   Kijmanawat A, 2019, J DIABETES INVEST, V10, P163, DOI 10.1111/jdi.12863
   Koleganova N, 2011, AM J PHYSIOL-RENAL, V301, pF344, DOI 10.1152/ajprenal.00626.2010
   Kulkarni SS, 2015, BBA-MOL BASIS DIS, V1852, P1114, DOI 10.1016/j.bbadis.2014.10.005
   Kumar KA, 2013, J NUTR BIOCHEM, V24, P25, DOI 10.1016/j.jnutbio.2012.01.004
   Lee WC, 2018, BIOMED J, V41, P96, DOI 10.1016/j.bj.2018.02.006
   Lewis RM, 2001, METABOLISM, V50, P562, DOI 10.1053/meta.2001.22516
   Lian Y, 2019, PSYCHIAT RES, V274, P66, DOI 10.1016/j.psychres.2019.01.096
   Liao JX, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22105273
   Litvinova L, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00020
   Liu TY, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-01349-w
   Lumey LH, 1998, P NUTR SOC, V57, P129, DOI 10.1079/PNS19980019
   Luoto R, 2010, BRIT J NUTR, V103, P1792, DOI 10.1017/S0007114509993898
   Ma N, 2012, J PREGNANCY, V2012, DOI 10.1155/2012/482690
   García AM, 2022, ROUTL ADV TRANSL INT, P1, DOI [10.4324/9781003125792-1, 10.1080/10408398.2022.2084028]
   Marotz Clarisse A., 2016, Yale Journal of Biology and Medicine, V89, P383
   Marques FZ, 2017, CIRCULATION, V135, P964, DOI [10.1161/CIRCULATIONAHA.116.024545, 10.1161/circulationaha.116.024545]
   Matamoros S, 2013, TRENDS MICROBIOL, V21, P167, DOI 10.1016/j.tim.2012.12.001
   McMillen IC, 2005, PHYSIOL REV, V85, P571, DOI 10.1152/physrev.00053.2003
   Mehta SH, 2012, J MATERN-FETAL NEO M, V25, P41, DOI 10.3109/14767058.2012.626927
   Milani C, 2017, MICROBIOL MOL BIOL R, V81, DOI 10.1128/MMBR.00036-17
   Mischke M, 2013, AM J PHYSIOL-REG I, V304, pR1065, DOI 10.1152/ajpregu.00551.2012
   Nataraj BH, 2020, MICROB CELL FACT, V19, DOI 10.1186/s12934-020-01426-w
   Natividad JM, 2018, CELL METAB, V28, P737, DOI 10.1016/j.cmet.2018.07.001
   Nguyen TMT, 2019, J PHYSIOL-LONDON, V597, P5619, DOI 10.1113/JP278531
   Nuesken KD, 2008, ENDOCRINOLOGY, V149, P1056, DOI 10.1210/en.2007-0891
   Okesene-Gafa KAM, 2019, AM J OBSTET GYNECOL, V221, DOI 10.1016/j.ajog.2019.03.003
   Andrade JMO, 2017, PROTEIN PEPTIDE LETT, V24, P827, DOI 10.2174/0929866524666170728145333
   Oliveira AC, 2015, LIFE SCI, V136, P151, DOI 10.1016/j.lfs.2015.06.024
   Othman M, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005941.pub2
   Pandey KR, 2015, J FOOD SCI TECH MYS, V52, P7577, DOI 10.1007/s13197-015-1921-1
   Pankey CL, 2017, DOMEST ANIM ENDOCRIN, V60, P67, DOI 10.1016/j.domaniend.2017.04.002
   Pascale A, 2018, ENDOCRINE, V61, P357, DOI 10.1007/s12020-018-1605-5
   Paul HA, 2019, FASEB J, V33, P5153, DOI 10.1096/fj.201801551R
   Picó C, 2021, EUR J CLIN INVEST, V51, DOI 10.1111/eci.13482
   Pluznick JL, 2017, CURR HYPERTENS REP, V19, DOI 10.1007/s11906-017-0722-5
   Pujo J, 2021, GUT, V70, P1088, DOI 10.1136/gutjnl-2020-321173
   Puppala S, 2018, J PHYSIOL-LONDON, V596, P5823, DOI 10.1113/JP275422
   Putnam K, 2012, AM J PHYSIOL-HEART C, V302, pH1219, DOI 10.1152/ajpheart.00796.2011
   Quan LH, 2020, GUT, V69, P1239, DOI 10.1136/gutjnl-2019-319114
   Rajagopal G, 2019, J APPL TOXICOL, V39, P751, DOI 10.1002/jat.3764
   Remacle C, 2011, AM J CLIN NUTR, V94, p1846S, DOI 10.3945/ajcn.110.001651
   Robledinos-Antón N, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/9372182
   Robles-Vera I, 2020, FASEB J, V34, P13626, DOI 10.1096/fj.202001532R
   Rodríguez L, 2015, J NUTR METAB, V2015, DOI 10.1155/2015/158091
   Romaní-Pérez M, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22115830
   Ros P, 2018, ENDOCRINOLOGY, V159, P810, DOI 10.1210/en.2017-00610
   Rousseau-Ralliard D, 2021, ENVIRON RES, V200, DOI 10.1016/j.envres.2021.111690
   Rubak YT, 2020, VET WORLD, V13, P345, DOI 10.14202/vetworld.2020.345-353
   Saad AF, 2016, AM J OBSTET GYNECOL, V215, DOI 10.1016/j.ajog.2016.03.038
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Schiattarella GG, 2017, EUR HEART J, V38, P2948, DOI 10.1093/eurheartj/ehx342
   Schulz LC, 2010, P NATL ACAD SCI USA, V107, P16757, DOI 10.1073/pnas.1012911107
   Shahriari A, 2021, BIOMED PHARMACOTHER, V141, DOI 10.1016/j.biopha.2021.111915
   Sharma D, 2017, J MATERN-FETAL NEO M, V30, P2263, DOI 10.1080/14767058.2016.1245285
   Sheen JM, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-24010-0
   Sherman SB, 2018, GUT MICROBES, V9, P400, DOI 10.1080/19490976.2018.1441664
   Shih MK, 2021, MOLECULES, V26, DOI 10.3390/molecules26134010
   Slabiak-Blaz N, 2015, KIDNEY BLOOD PRESS R, V40, P413, DOI 10.1159/000368515
   Stanner S A, 2001, Twin Res, V4, P287, DOI 10.1375/twin.4.5.287
   Sunu P, 2019, VET WORLD, V12, P2046, DOI 10.14202/vetworld.2019.2046-2051
   Tain YL, 2015, NUTR METAB CARDIOVAS, V25, P1146, DOI 10.1016/j.numecd.2015.08.002
   Tain YL, 2014, FREE RADICAL RES, V48, P580, DOI 10.3109/10715762.2014.895341
   Tain YL, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23126620
   Tain YL, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10030420
   Tain YL, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101407
   Tain YL, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19092584
   Tain YL, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19061744
   Tain YL, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201800066
   Tain YL, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19041066
   Tain YL, 2017, BIOL REPROD, V97, P636, DOI 10.1093/biolre/iox115
   Tain YL, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18040841
   Tain YL, 2017, TOXINS, V9, DOI 10.3390/toxins9030092
   Tain YL, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17010023
   Tain YL, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17010020
   Tain YL, 2015, J NUTR BIOCHEM, V26, P642, DOI 10.1016/j.jnutbio.2014.12.017
   Tain YL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055420
   Takaya J, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111745
   Tam WH, 2017, DIABETES CARE, V40, P679, DOI 10.2337/dc16-2397
   Tare M, 2011, J PHYSIOL-LONDON, V589, P4777, DOI 10.1113/jphysiol.2011.214726
   Tenorio-Jiménez C, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010124
   Thaeomor A, 2017, ADV EXP MED BIOL, V975, P295, DOI 10.1007/978-94-024-1079-2_26
   Thushara RM, 2016, FOOD FUNCT, V7, P632, DOI [10.1039/c5fo01190f, 10.1039/C5FO01190F]
   Tomat A, 2010, BRIT J NUTR, V104, P382, DOI 10.1017/S0007114510000759
   Tsai TA, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17082780
   Tsosura TVS, 2019, INT ENDOD J, V52, P1040, DOI 10.1111/iej.13096
   Unger S, 2015, PEDIATR RES, V77, P205, DOI 10.1038/pr.2014.162
   Vaag A, 2007, CURR OPIN CLIN NUTR, V10, P591, DOI 10.1097/MCO.0b013e3282ab9ea6
   Vandenplas Y, 2020, NUTRITION, V78, DOI 10.1016/j.nut.2020.110812
   Vega CC, 2016, J PHYSIOL-LONDON, V594, P1483, DOI 10.1113/JP271543
   Velasquez MT, 2016, TOXINS, V8, DOI 10.3390/toxins8110326
   Vickers MH, 2001, J ENDOCRINOL, V170, P323, DOI 10.1677/joe.0.1700323
   Vitali B, 2012, BMC MICROBIOL, V12, DOI 10.1186/1471-2180-12-236
   Walle T, 2004, DRUG METAB DISPOS, V32, P1377, DOI 10.1124/dmd.104.000885
   Wang Guoying, 2014, Curr Environ Health Rep, V1, P78
   Wang J, 2016, SCI REP-UK, V6, DOI 10.1038/srep39469
   Wang ZN, 2018, PROTEIN CELL, V9, P416, DOI 10.1007/s13238-018-0549-0
   Wang ZN, 2015, CELL, V163, P1585, DOI 10.1016/j.cell.2015.11.055
   Wankhade UD, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0175675
   Weihe P, 2019, CURR OBES REP, V8, P472, DOI 10.1007/s13679-019-00357-x
   Wiedmer EB, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.819882
   Wilck N, 2017, NATURE, V551, P585, DOI 10.1038/nature24628
   Williams L, 2014, BBA-MOL BASIS DIS, V1842, P507, DOI 10.1016/j.bbadis.2013.07.006
   Wlodek ME, 2008, KIDNEY INT, V74, P187, DOI 10.1038/ki.2008.153
   Wu ZH, 2014, EUR J NUTR, V53, P1669, DOI 10.1007/s00394-014-0673-4
   Xiao DL, 2015, BIOL REPROD, V93, DOI 10.1095/biolreprod.115.132381
   Yamada-Obara N, 2016, CLIN EXP NEPHROL, V20, P853, DOI 10.1007/s10157-016-1265-9
   Zarocostas John, 2010, BMJ, V341, pc7065, DOI 10.1136/bmj.c7065
   Zhang HQ, 2014, DIABETOLOGIA, V57, P2165, DOI 10.1007/s00125-014-3316-7
   Zhou LY, 2018, BIOSCIENCE REP, V38, DOI 10.1042/BSR20171234
   Zólkiewicz J, 2020, NUTRIENTS, V12, DOI 10.3390/nu12082189
   Zou TD, 2017, J PHYSIOL-LONDON, V595, P1547, DOI 10.1113/JP273478
   Zuchowski Y, 2021, PHYSIOL REP, V9, DOI 10.14814/phy2.14941
NR 200
TC 8
Z9 8
U1 1
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP
PY 2022
VL 23
IS 17
AR 10173
DI 10.3390/ijms231710173
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 4J2AL
UT WOS:000851071300001
PM 36077575
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Moukayed, M
   Grant, WB
AF Moukayed, Meis
   Grant, William B.
TI Linking the metabolic syndrome and obesity with vitamin D status: risks
   and opportunities for improving cardiometabolic health and well-being
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Review
DE vitamin D; metabolic syndrome; obesity; adipose tissue; cardiovascular
   disease; risk reduction
ID SERUM 25-HYDROXYVITAMIN D; D SUPPLEMENTATION; 1,25-DIHYDROXYVITAMIN D-3;
   ADIPOSE-TISSUE; D-RECEPTOR; OXIDATIVE STRESS; COLORECTAL-CANCER;
   DOSE-RESPONSE; ACTIVATION; INFLAMMATION
AB The global death toll from noncommunicable diseases is exceptionally high, reported to cause 71% of global deaths worldwide. Metabolic syndrome risk factors, especially excessive adiposity and obesity, are at the heart of the problem resulting in increased comorbidities such as cardiometabolic diseases and cancer, increased health costs, poorer quality of life, and shortened survival. Vitamin D-3 can positively reverse many of these adverse effects and outcomes through blocking signaling mechanisms that predispose to cardiometabolic and metastatic disease. As an affordable natural agent, vitamin D-3 can be used to counteract obesity-induced inflammation, block early adipogenesis, enhance glucose uptake, counteract hyperleptinemia, ameliorate insulin resistance, and reduce hypertension. This is supported by data from in vitro, in vivo and epidemiological studies and clinical trials. We propose that everyone in general and obese patients in particular consider raising 25-hydroxyvitamin D levels through UVB exposure and/or supplemental vitamin D(3 )intake to reduce cardiometabolic and metastatic disease and increase longevity.
C1 [Moukayed, Meis] Amer Univ Dubai, Sch Arts & Sci, Dubai, U Arab Emirates.
   [Grant, William B.] Sunlight Nutr & Hlth Res Ctr, POB 641603, San Francisco, CA 94164 USA.
C3 American University in Dubai (AUD)
RP Grant, WB (corresponding author), Sunlight Nutr & Hlth Res Ctr, POB 641603, San Francisco, CA 94164 USA.
EM wbgrant@infonline.net
RI Grant, William/B-8311-2009
OI Moukayed, Meis/0000-0003-3951-7712
CR Abbas MA, 2017, J STEROID BIOCHEM, V165, P369, DOI 10.1016/j.jsbmb.2016.08.004
   Akbari M, 2018, HORM METAB RES, V50, P271, DOI 10.1055/s-0044-101355
   Al Maskari Masoud Y, 2006, Sultan Qaboos Univ Med J, V6, P27
   Al-Khalidi B, 2017, NUTR J, V16, DOI 10.1186/s12937-017-0237-6
   Allott EH, 2015, ENDOCR-RELAT CANCER, V22, pR365, DOI 10.1530/ERC-15-0400
   Babaei P, 2017, DIABETOL METAB SYNDR, V9, DOI 10.1186/s13098-017-0288-z
   Baggerly CA, 2015, J AM COLL NUTR, V34, P359, DOI 10.1080/07315724.2015.1039866
   Berger NA, 2014, ANN NY ACAD SCI, V1311, P57, DOI 10.1111/nyas.12416
   Bertram MY, 2018, LANCET, V391, P2071, DOI [10.1016/S0140-6736(18)30665-2, 10.1016/s0140-6736(18)30665-2]
   Bommer C, 2018, DIABETES CARE, V41, P963, DOI 10.2337/dc17-1962
   Carlberg C, 2013, STEROIDS, V78, P127, DOI 10.1016/j.steroids.2012.10.019
   Cawley J, 2012, J HEALTH ECON, V31, P219, DOI 10.1016/j.jhealeco.2011.10.003
   Chen GA, 2011, CLIN CANCER RES, V17, P817, DOI 10.1158/1078-0432.CCR-10-1789
   Cheng S, 2016, CURR MOL MED, V16, P747, DOI 10.2174/1566524016666160920111407
   Cifarelli V, 2015, Int J Diabetol Vasc Dis Res, V2015, DOI 10.19070/2328-353X-SI04001
   Demay MB, 2013, CALCIFIED TISSUE INT, V92, P99, DOI 10.1007/s00223-012-9633-2
   Dharmashankar K, 2010, CURR HYPERTENS REP, V12, P448, DOI 10.1007/s11906-010-0150-2
   Didriksen A, 2013, EUR J ENDOCRINOL, V169, P559, DOI 10.1530/EJE-13-0233
   Dikalov SI, 2019, ANTIOXID REDOX SIGN, V31, P710, DOI 10.1089/ars.2018.7632
   DILWORTH FJ, 1995, J BIOL CHEM, V270, P16766, DOI 10.1074/jbc.270.28.16766
   DOUGLAS AS, 1991, LANCET, V337, P1393, DOI 10.1016/0140-6736(91)93069-L
   Drincic A, 2013, J CLIN ENDOCR METAB, V98, P4845, DOI 10.1210/jc.2012-4103
   Drincic AT, 2012, OBESITY, V20, P1444, DOI 10.1038/oby.2011.404
   Fernández-Arroyo S, 2019, NUTRIENTS, V11, DOI 10.3390/nu11051194
   Forman JP, 2013, HYPERTENSION, V61, P779, DOI 10.1161/HYPERTENSIONAHA.111.00659
   García-Jiménez C, 2016, BRIT J CANCER, V114, P716, DOI 10.1038/bjc.2016.37
   Garland CF, 2017, J STEROID BIOCHEM, V168, P1, DOI 10.1016/j.jsbmb.2016.12.003
   Ghaedian MM, 2020, CLIN EXP HYPERTENS, V42, P31, DOI 10.1080/10641963.2018.1557684
   Goulao B, 2018, AM J CLIN NUTR, V107, P652, DOI 10.1093/ajcn/nqx047
   Grant WB, 2019, CURR NUTR REP, V8, P203, DOI 10.1007/s13668-019-0262-5
   Grant WB, 2018, J STEROID BIOCHEM, V177, P266, DOI 10.1016/j.jsbmb.2017.08.009
   Grant WB, 2017, J STEROID BIOCHEM, V173, P5, DOI 10.1016/j.jsbmb.2017.01.003
   Grant WB, 2015, ANTICANCER RES, V35, P1154
   Han TS, 2016, JRSM CARDIOVASC DIS, V5, DOI 10.1177/2048004016633371
   Heaney RP, 2009, J AM COLL NUTR, V28, P252, DOI 10.1080/07315724.2009.10719779
   Hoseini R, 2017, NUTRITION, V36, P54, DOI 10.1016/j.nut.2016.06.010
   Imga NN, 2019, ARCH MED SCI, V15, P598, DOI 10.5114/aoms.2018.75864
   Jungert A, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-42
   Karczewski J, 2018, EUR CYTOKINE NETW, V29, P83, DOI 10.1684/ecn.2018.0415
   Knudson JD, 2005, AM J PHYSIOL-HEART C, V289, pH48, DOI 10.1152/ajpheart.01159.2004
   Kong J, 2006, AM J PHYSIOL-ENDOC M, V290, pE916, DOI 10.1152/ajpendo.00410.2005
   Landrier JF, 2016, P NUTR SOC, V75, P38, DOI 10.1017/S0029665115004164
   Lee SH, 2013, NUTR METAB CARDIOVAS, V23, P785, DOI 10.1016/j.numecd.2012.04.013
   Li GL, 2019, REPROD SCI, V26, P223, DOI 10.1177/1933719118766253
   Li YC, 2002, J CLIN INVEST, V110, P229, DOI [10.1172/JCI200215219, 10.1172/JCI0215219]
   Lira FS, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-37
   Lira FS, 2012, CYTOKINE, V57, P98, DOI 10.1016/j.cyto.2011.10.001
   Lupton JR, 2016, J CLIN LIPIDOL, V10, P72, DOI 10.1016/j.jacl.2015.09.006
   Manson JE, 2019, NEW ENGL J MED, V380, P33, DOI [10.1056/NEJMoa1809944, 10.1056/nejmoa1809944]
   Mansournia MA, 2018, HORM METAB RES, V50, P429, DOI 10.1055/a-0630-1303
   Marcotorchino J, 2013, HORM MOL BIOL CLIN I, V15, P123, DOI 10.1515/hmbci-2013-0027
   Marcotorchino J, 2012, MOL NUTR FOOD RES, V56, P1771, DOI 10.1002/mnfr.201200383
   MAWER EB, 1972, CLIN SCI, V43, P413, DOI 10.1042/cs0430413
   MCCOLLUM EV, 1967, J NUTR, V91, P11, DOI 10.1093/jn/91.2_Suppl.11
   MELLANBY MA, 1989, NUTRITION, V5, P81
   Mirhosseini N, 2018, FRONT CARDIOVASC MED, V5, DOI 10.3389/fcvm.2018.00087
   Mirhosseini N, 2017, NUTRIENTS, V9, DOI 10.3390/nu9111244
   Moukayed M, 2017, REV ENDOCR METAB DIS, V18, P167, DOI 10.1007/s11154-017-9415-2
   Moukayed M, 2013, NUTRIENTS, V5, P3993, DOI 10.3390/nu5103993
   Mousa A, 2017, AM J CLIN NUTR, V105, P1372, DOI 10.3945/ajcn.117.152736
   Mutt SJ, 2012, FASEB J, V26, P4400, DOI 10.1096/fj.12-210880
   Niroomand M, 2019, DIABETES RES CLIN PR, V148, P1, DOI 10.1016/j.diabres.2018.12.008
   Nobre JL, 2018, GEN COMP ENDOCR, V266, P1, DOI 10.1016/j.ygcen.2018.01.014
   Organization WH, 2011, OB OV FACTSH
   Organization WH, 2018, NONC DIS COUNTR PROF
   Pannu PK, 2016, NUTR RES, V36, P201, DOI 10.1016/j.nutres.2015.11.013
   Park SK, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0193070
   Pittas AG, 2019, NEW ENGL J MED, V381, P520, DOI 10.1056/NEJMoa1900906
   Ricciardi CJ, 2015, EUR J NUTR, V54, P1001, DOI 10.1007/s00394-014-0778-9
   Rovner AJ, 2008, J AM DIET ASSOC, V108, P1512, DOI 10.1016/j.jada.2008.06.433
   Sergeev IN, 2014, HORM MOL BIOL CLIN I, V20, P43, DOI 10.1515/hmbci-2014-0035
   Sergeev IN, 2009, BIOCHEM BIOPH RES CO, V384, P18, DOI 10.1016/j.bbrc.2009.04.078
   Teixeira TM, 2017, J NUTR, V147, P506, DOI 10.3945/jn.116.239475
   Tsujimoto T, 2017, INT J CANCER, V141, P102, DOI 10.1002/ijc.30729
   Wacker M, 2013, NUTRIENTS, V5, P111, DOI 10.3390/nu5010111
   Wamberg L, 2013, HORM METAB RES, V45, P456, DOI 10.1055/s-0032-1331746
   Wamberg L, 2013, INT J OBESITY, V37, P651, DOI 10.1038/ijo.2012.112
   Weyland PG, 2014, NUTRIENTS, V6, P3403, DOI 10.3390/nu6093403
   Wimalawansa SJ, 2019, J Steroids Horm Sci., V10, P2, DOI [10.24105/2157-7536.10.198, DOI 10.24105/2157-7536.10.198]
   Wimalawansa SJ, 2018, J STEROID BIOCHEM, V175, P29, DOI 10.1016/j.jsbmb.2016.12.016
   Wong KE, 2009, AM J PHYSIOL-ENDOC M, V296, pE820, DOI 10.1152/ajpendo.90763.2008
   Wortsman J, 2000, AM J CLIN NUTR, V72, P690, DOI 10.1093/ajcn/72.3.690
   Yamagishi SI, 2001, J BIOL CHEM, V276, P25096, DOI 10.1074/jbc.M007383200
   Yu YT, 2018, ANN NUTR METAB, V73, P62, DOI 10.1159/000490358
   Zhang RH, 2017, AM J CLIN NUTR, V105, P810, DOI 10.3945/ajcn.116.140392
NR 85
TC 20
Z9 20
U1 0
U2 5
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABETES METAB SYNDR
JI Diabetes Metab. Syndr. Obes.
PY 2019
VL 12
BP 1437
EP 1447
DI 10.2147/DMSO.S176933
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA IU2XZ
UT WOS:000483444600001
PM 31496777
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Sutra, T
   Oiry, C
   Azay-Milhau, J
   Youl, E
   Magous, R
   Teissèdre, PL
   Cristol, JP
   Cros, G
AF Sutra, Thibault
   Oiry, Catherine
   Azay-Milhau, Jacqueline
   Youl, Estelle
   Magous, Richard
   Teissedre, Pierre-Louis
   Cristol, Jean-Paul
   Cros, Gerard
TI Preventive Effects of Nutritional Doses of Polyphenolic Molecules on
   Cardiac Fibrosis Associated with Metabolic Syndrome: Involvement of
   Osteopontin and Oxidative Stress
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE Polyphenols; fructose; rat; collagen I; osteopontin; ROS
ID INSULIN-RESISTANCE; ANGIOTENSIN-II; NADPH OXIDASE; HEART; HYPERTENSION;
   HYPERTROPHY; MECHANISMS; EXPRESSION; DISEASE; KINASE
AB We previously showed that grape extracts enriched in different polyphenolic families were similarly able to prevent reactive oxygen species (ROS) production, although having differential effects on various features of metabolic syndrome when administered at a dose of 21 mg/kg to the fructose (60%)-fed rat (a model of metabolic syndrome). In the present work, we analyzed on the same model the effect of pure polyphenolic molecules (catechin, resveratrol, delphinidin, and gallic acid) administered at a dose of 2.1 mg/kg. Delphinidin and gallic acid prevented insulin resistance, while gallic acid prevented the elevation of blood pressure. All molecules prevented cardiac ROS overproduction and NADPH overexpression. We also showed that fructose feeding was associated with cardiac fibrosis (accumulation of collagen 1) and expression of osteopontin, a factor induced by ROS and a collagen I expression inducer. Collagen I and osteopontin expressions were prevented by the administration of all polyphenolic molecules. The potential use of polyphenols in the prevention of cardiac fibrosis should be further explored.
C1 [Oiry, Catherine; Azay-Milhau, Jacqueline; Youl, Estelle; Magous, Richard; Cros, Gerard] Univ Montpellier I, CPID, F-34093 Montpellier 5, France.
   [Sutra, Thibault; Cristol, Jean-Paul] Univ Montpellier I, Inst Univ Rech Clin Nutr Humaine Biodisponibilite, EA 4188, F-34093 Montpellier 5, France.
   [Oiry, Catherine; Azay-Milhau, Jacqueline; Youl, Estelle; Magous, Richard; Cros, Gerard] CNRS, UMR 5232, Montpellier, France.
   [Teissedre, Pierre-Louis] Univ Bordeaux 2, Fac Oenol, UMR 1219, ISVV,Lab Chim Appl, F-33405 Talence, France.
C3 Universite de Montpellier; Universite de Montpellier; Centre National de
   la Recherche Scientifique (CNRS); Universite de Bordeaux; Institut
   National de la Sante et de la Recherche Medicale (Inserm)
RP Cros, G (corresponding author), Univ Montpellier I, CPID, F-34093 Montpellier 5, France.
EM gerard.cros@univ-montp1.fr
RI Teissedre, Pierre-Louis/I-6885-2016
OI TEISSEDRE, Pierre-Louis/0000-0002-0115-5456; Azay-Milhau,
   Jacqueline/0000-0001-9965-9996; , Jean-Paul Cristol/0000-0001-8563-7278;
   Youl, Estella/0000-0002-0185-0846
FU French Minister of Agriculture (ONIVINS)
FX The authors thank the financial support of the French Minister of
   Agriculture (ONIVINS).
CR Al-Awwadi NA, 2004, J AGR FOOD CHEM, V52, P5593, DOI 10.1021/jf049295g
   Al-Awwadi NA, 2005, J AGR FOOD CHEM, V53, P151, DOI 10.1021/jf048919f
   Arribas SM, 2006, PHARMACOL THERAPEUT, V111, P771, DOI 10.1016/j.pharmthera.2005.12.003
   Brower GL, 2006, EUR J CARDIO-THORAC, V30, P604, DOI 10.1016/j.ejcts.2006.07.006
   Cai H, 2003, TRENDS PHARMACOL SCI, V24, P471, DOI 10.1016/S0165-6147(03)00233-5
   Chandrashekhar Y, 2005, J LAB CLIN MED, V145, P5, DOI 10.1016/j.lab.2004.11.001
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   de Simone Giovanni, 2002, Adv Clin Path, V6, P3
   Delbosc S, 2005, ATHEROSCLEROSIS, V179, P43, DOI 10.1016/j.atherosclerosis.2004.10.018
   Díez J, 2004, HYPERTENSION, V43, P1164, DOI 10.1161/01.HYP.0000128620.57061.67
   Díez J, 2005, NAT CLIN PRACT CARD, V2, P209, DOI 10.1038/ncpcardio0158
   Diez Javier, 2007, J Clin Hypertens (Greenwich), V9, P546, DOI 10.1111/j.1524-6175.2007.06626.x
   Graf K, 2004, HYPERTENSION, V44, P809, DOI 10.1161/01.HYP.0000148459.25908.49
   Guo ZX, 2007, AM J PHYSIOL-HEART C, V292, pH1728, DOI 10.1152/ajpheart.01328.2005
   Hodgson JM, 2005, J HYPERTENS, V23, P47, DOI 10.1097/00004872-200501000-00012
   Ikeda M, 2007, MED SCI MONITOR, V13, pBR40
   Kern M, 2007, MOL NUTR FOOD RES, V51, P1163, DOI 10.1002/mnfr.200700004
   Kim Jeong-A., 2008, Endocrine Metabolic & Immune Disorders-Drug Targets, V8, P82, DOI 10.2174/187153008784534349
   Kwon SH, 2007, J MED FOOD, V10, P552, DOI 10.1089/jmf.2006.147
   Perez-Vizcaino F, 2006, FREE RADICAL RES, V40, P1054, DOI 10.1080/10715760600823128
   Querejeta R, 2004, CIRCULATION, V110, P1263, DOI 10.1161/01.CIR.0000140973.60992.9A
   Sanae F, 2002, PLANTA MED, V68, P690, DOI 10.1055/s-2002-33806
   Schellings MWM, 2004, CARDIOVASC RES, V64, P24, DOI 10.1016/j.cardiores.2004.06.006
   Suzuki M, 1997, JPN J PHARMACOL, V74, P297, DOI 10.1254/jjp.74.297
   Verma S, 2000, J HYPERTENS, V18, P1445, DOI 10.1097/00004872-200018100-00012
   Xie ZL, 2004, J CELL PHYSIOL, V198, P399, DOI 10.1002/jcp.10419
   Xie ZL, 2001, J CELL PHYSIOL, V188, P132, DOI 10.1002/jcp.1104
NR 27
TC 29
Z9 30
U1 0
U2 7
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD DEC 24
PY 2008
VL 56
IS 24
BP 11683
EP 11687
DI 10.1021/jf802357g
PG 5
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA 385GJ
UT WOS:000261802400019
PM 19049292
DA 2025-06-11
ER

PT J
AU Paz-Graniel, I
   Babio, N
   Nishi, SK
   Martínez-González, MA
   Corella, D
   Fitó, M
   Martínez, A
   Alonso-Gómez, AM
   Wärnberg, J
   Vioque, J
   Romaguera, D
   López-Miranda, J
   Estruch, R
   Tinahones, FJ
   Santos-Lozano, JM
   Serra-Majem, JL
   Bueno-Cavanillas, A
   Tur, JA
   Sánchez, VM
   Pintó, X
   Delgado-Rodríguez, M
   Matía-Martín, P
   Vidal, J
   Calderon-Sanchez, C
   Daimiel, L
   Ros, E
   Fernández-Aranda, F
   Toledo, E
   Valle-Hita, C
   Sorli, JV
   Lassale, C
   Garcia-Rios, A
   Oncina-Canovas, A
   Barón-Lopez, FJ
   Zulet, MA
   Rayó, E
   Casas, R
   Thomas-Carazo, E
   Tojal-Sierra, L
   Damas-Fuentes, M
   Ruiz-Canela, M
   de las Heras-delgado, S
   Fernandez-Carrión, R
   Castañer, O
   Peña-Orihuela, PJ
   Gonzalez-Palacios, S
   Buil-Cosiales, P
   Goday, A
   Salas-Salvadó, J
AF Paz-Graniel, Indira
   Babio, Nancy
   Nishi, Stephanie K.
   Martinez-Gonzalez, Miguel angel
   Corella, Dolores
   Fito, Montserrat
   Martinez, Alfredo
   Alonso-Gomez, angel M.
   Waernberg, Julia
   Vioque, Jesus
   Romaguera, Dora
   Lopez-Miranda, Jose
   Estruch, Ramon
   Tinahones, Francisco J.
   Santos-Lozano, Jose Manuel
   Serra-Majem, J. Luis
   Bueno-Cavanillas, Aurora
   Tur, Josep A.
   Sanchez, Vicente Martin
   Pinto, Xavier
   Delgado-Rodriguez, Miguel
   Matia-Martin, Pilar
   Vidal, Josep
   Calderon-Sanchez, Cristina
   Daimiel, Lidia
   Ros, Emili
   Fernandez-Aranda, Fernando
   Toledo, Estefania
   Valle-Hita, Cristina
   Sorli, Jose V.
   Lassale, Camille
   Garcia-Rios, Antonio
   Oncina-Canovas, Alejandro
   Baron-Lopez, Francisco Javier
   Zulet, M. Angeles
   Rayo, Elena
   Casas, Rosa
   Thomas-Carazo, Esther
   Tojal-Sierra, Lucas
   Damas-Fuentes, Miguel
   Ruiz-Canela, Miguel
   de las Heras-delgado, Sara
   Fernandez-Carrion, Rebeca
   Castaner, Olga
   Pena-Orihuela, Patricia J.
   Gonzalez-Palacios, Sandra
   Buil-Cosiales, Pilar
   Goday, Albert
   Salas-Salvado, Jordi
TI How Did the COVID-19 Lockdown Pandemic Affect the Depression
   Symptomatology in Mediterranean Older Adults with Metabolic Syndrome?
SO DEPRESSION AND ANXIETY
LA English
DT Article
AB Background and Aims. To control the COVID-19 spread, in March 2020, a forced home lockdown was established in Spain. In the present study, we aimed to assess the effect of mobility and social COVID-19-established restrictions on depressive symptomatology in older adults with metabolic syndrome. We hypothesize that severe restrictions might have resulted in detrimental changes in depressive symptomatology.
   Methods. 2,312 PREDIMED-Plus study participants (men = 53:9%; mean age = 64:9 +/- 4:8 years) who completed a COVID-19 lockdown questionnaire to assess the severity of restrictions/lockdown and the validated Spanish version of the Beck Depression Inventory-II (BDI-II) during the three established phases concerning the COVID-19 lockdown in Spain (prelockdown, lockdown, and postlockdown) were included in this longitudinal analysis. Participants were categorized according to high or low lockdown severity. Analyses of covariance were performed to assess changes in depressive symptomatology across lockdown phases.
   Results. No significant differences in participant depression symptomatology changes were observed between lockdown severity categories (low/high) at the studied phases. During the lockdown phase, participants showed a decrease in BDI-II score compared to the prelockdown phase (mean (95% CI), -0.48 (-0.24, -0.72), P < 0:001); a nonsignificantly larger decrease was observed in participants allocated in the low-lockdown category (low: -0.59 (-0.95, -0.23), high: -0.43 (-0.67, -0.19)). Similar decreases in depression symptomatology were found for the physical environment dimension. The post- and prelockdown phase BDI-II scores were roughly similar.
   Conclusions. The COVID-19 pandemic lockdown was associated with a decrease in depressive symptomatology that returned to prelockdown levels after the lockdown. The degree of lockdown was not associated with depressive symptomatology. The potential preventive role of the physical environment and social interactions on mental disorders during forced home lockdown should be further studied. This trial is registered with ISRCTN89898870. Retrospectively registered on 24 July 2014.
C1 [Paz-Graniel, Indira; Babio, Nancy; Nishi, Stephanie K.; Martinez-Gonzalez, Miguel angel; Corella, Dolores; Fito, Montserrat; Martinez, Alfredo; Alonso-Gomez, angel M.; Waernberg, Julia; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Tinahones, Francisco J.; Santos-Lozano, Jose Manuel; Serra-Majem, J. Luis; Tur, Josep A.; Pinto, Xavier; Daimiel, Lidia; Ros, Emili; Fernandez-Aranda, Fernando; Toledo, Estefania; Valle-Hita, Cristina; Sorli, Jose V.; Lassale, Camille; Garcia-Rios, Antonio; Baron-Lopez, Francisco Javier; Zulet, M. Angeles; Casas, Rosa; Tojal-Sierra, Lucas; Damas-Fuentes, Miguel; Ruiz-Canela, Miguel; de las Heras-delgado, Sara; Fernandez-Carrion, Rebeca; Castaner, Olga; Pena-Orihuela, Patricia J.; Buil-Cosiales, Pilar; Goday, Albert; Salas-Salvado, Jordi] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr, Madrid, Spain.
   [Paz-Graniel, Indira; Babio, Nancy; Nishi, Stephanie K.; Valle-Hita, Cristina; de las Heras-delgado, Sara; Salas-Salvado, Jordi] Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Unitat Nutricio, Reus, Spain.
   [Paz-Graniel, Indira; Babio, Nancy; Nishi, Stephanie K.; Valle-Hita, Cristina; de las Heras-delgado, Sara; Salas-Salvado, Jordi] Inst Invest Sanit Pere Virgili IISPV, Reus, Spain.
   [Nishi, Stephanie K.] Toronto Diet 3D Digest Tract & Dis Knowledge Synth, Toronto, ON, Canada.
   [Nishi, Stephanie K.] St Michaels Hosp, Clin Nutr & Risk Factor Modificat Ctr, Unity Hlth Toronto, Toronto, ON, Canada.
   [Martinez-Gonzalez, Miguel angel; Toledo, Estefania; Ruiz-Canela, Miguel] Univ Navarra, Dept Prevent Med & Publ Hlth, IDISNA, Pamplona, Spain.
   [Martinez-Gonzalez, Miguel angel] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
   [Corella, Dolores; Sorli, Jose V.; Fernandez-Carrion, Rebeca] Univ Valencia, Dept Prevent Med, Valencia, Spain.
   [Fito, Montserrat; Lassale, Camille; Castaner, Olga; Goday, Albert] Inst Hosp Mar Invest Med Municipal Invest Med IMIM, Unit Cardiovasc Risk & Nutr, Barcelona, Spain.
   [Martinez, Alfredo; Zulet, M. Angeles] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona, Spain.
   [Martinez, Alfredo; Zulet, M. Angeles; Buil-Cosiales, Pilar] Navarra Inst Hlth Res IdisNA, Pamplona 31008, Spain.
   [Martinez, Alfredo; Alonso-Gomez, angel M.; Tojal-Sierra, Lucas] Bioaraba Hlth Res Inst, Cardiovasc Resp & Metab Area, Vitoria, Spain.
   [Corella, Dolores; Alonso-Gomez, angel M.; Tojal-Sierra, Lucas] Araba Univ Hosp, Osakidetza Basque Hlth Serv, Vitoria-gasteiz, Spain.
   [Alonso-Gomez, angel M.; Sanchez, Vicente Martin; Tojal-Sierra, Lucas] Univ Basque Country UPV EHU, Vitoria, Spain.
   [Waernberg, Julia] Univ Malaga, Sch Hlth Sci, EpiPHAAN Res Grp, Inst Invest Biomed Malaga IBIMA, Malaga, Spain.
   [Vioque, Jesus; Bueno-Cavanillas, Aurora] Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.
   [Vioque, Jesus] Univ Miguel Hernandez, Inst Invest Sanit & Biomed Alicante, ISABIAL UMH, Alicante 03550, Spain.
   [Romaguera, Dora] Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca, Spain.
   [Lopez-Miranda, Jose] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIB, Dept Internal Med, Cordoba, Spain.
   [Estruch, Ramon] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Internal Med, Barcelona, Spain.
   [Estruch, Ramon] Univ Barcelona, Inst Recerca Nutr & Seguretat Alimentaria INSA UB, Barcelona, Spain.
   [Tinahones, Francisco J.] Univ Malaga, Virgen Victoria Hosp, Dept Endocrinol, Inst Invest Biomed Malaga IBIMA, Malaga, Spain.
   [Santos-Lozano, Jose Manuel] Dist Sanit Atenc Primaria Sevilla, Dept Family Med, Res Unit, Seville, Spain.
   [Serra-Majem, J. Luis] Univ Palmas Gran Canaria, Ctr Hosp Univ Insular Materno Infantil CHUIMI, Res Inst Biomed & Hlth Sci IUIBS, Canarian Hlth Serv, Las Palmas Gran Canaria, Spain.
   [Bueno-Cavanillas, Aurora] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain.
   [Tur, Josep A.] Univ Balear Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain.
   [Sanchez, Vicente Martin] Univ Leon, Inst Biomed IBIOMED, Leon, Spain.
   [Pinto, Xavier] Hosp Univ Bellvitge, Lipids & Vasc Risk Unit, Internal Med, IDIBELL, Barcelona, Spain.
   [Pinto, Xavier] Univ Barcelona, Sch Med & Hlth Sci, Dept Clin Sci, Barcelona 08907, Spain.
   [Delgado-Rodriguez, Miguel] Univ Jaen, Inst Univ Invest Olivar & Aceites Ol INUO, Fac Med, Div Prevent Med, Jaen, Spain.
   [Matia-Martin, Pilar] Univ Complutense, Inst Invest Sanit Hosp Clin San Carlos IdISSC, Dept Endocrinol & Nutr, Madrid, Spain.
   [Vidal, Josep] Inst Salud Carlos III ISCIII, CIBER Diabet & Enfermedades Metab CIBERDEM, Madrid, Spain.
   [Vidal, Josep] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol, Barcelona, Spain.
   [Calderon-Sanchez, Cristina] Univ Autonoma, Hosp Fdn Jimenez Diaz, Dept Endocrinol & Nutr, Inst Invest Biomed IISFJD, Madrid, Spain.
   [Daimiel, Lidia] CEI UAM CSIC, Precis Nutr & Obes Program, Nutr Control Epigenome Grp, IMDEA Food, Madrid, Spain.
   [Ros, Emili] Hosp Clin Barcelona, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol & Nutr, Lipid Clin, Barcelona, Spain.
   [Fernandez-Aranda, Fernando] Inst Invest Biomed Bellvitge IDIBELL, Psychoneurobiol Eating & Addict Behav Grp, Barcelona 08907, Spain.
   [Fernandez-Aranda, Fernando] Univ Hosp Bellvitge, Clin Psychol Unit, Barcelona 08907, Spain.
   [Lassale, Camille] Univ Pompeu Fabra UPF, Dept Med & Life Sci, Barcelona 08003, Spain.
   [Thomas-Carazo, Esther] Ctr Salud Gran Capitan, Serv Andaluz Salud, Granada, Andorra.
   [Buil-Cosiales, Pilar] Serv Navarro Salud, Atenc Primaria, Navarra, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Instituto de
   Salud Carlos III; Universitat Rovira i Virgili; University of Toronto;
   Saint Michaels Hospital Toronto; University of Navarra; Harvard
   University; Harvard T.H. Chan School of Public Health; University of
   Valencia; University of Navarra; University of Navarra; Bioaraba Health
   Research Institute; University Hospital of Araba; University of Basque
   Country; Instituto de Investigacion Biomedica de Malaga y Plataforma en
   Nanomedicina (IBIMA); Universidad de Malaga; Instituto de Salud Carlos
   III; CIBER - Centro de Investigacion Biomedica en Red; CIBERESP; General
   University Hospital of Alicante; Universidad Miguel Hernandez de Elche;
   Universitat d'Alacant; Instituto de Investigacion Sanitaria y Biomedica
   de Alicante (ISABIAL); Institut Investigacio Sanitaria Illes Balears
   (IdISBa); Universidad de Cordoba; University of Barcelona; Hospital
   Clinic de Barcelona; IDIBAPS; University of Barcelona; Instituto de
   Investigacion Biomedica de Malaga y Plataforma en Nanomedicina (IBIMA);
   Universidad de Malaga; Universidad de Las Palmas de Gran Canaria;
   University of Granada; Universitat de les Illes Balears; Universidad de
   Leon; University of Barcelona; Institut d'Investigacio Biomedica de
   Bellvitge (IDIBELL); Bellvitge University Hospital; University of
   Barcelona; Universidad de Jaen; Complutense University of Madrid; CIBER
   - Centro de Investigacion Biomedica en Red; CIBERDEM; University of
   Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Autonomous University
   of Madrid; Fundacion Jimenez Diaz; IMDEA Food Institute; Consejo
   Superior de Investigaciones Cientificas (CSIC); University of Barcelona;
   Hospital Clinic de Barcelona; IDIBAPS; Institut d'Investigacio Biomedica
   de Bellvitge (IDIBELL); University of Barcelona; Institut d'Investigacio
   Biomedica de Bellvitge (IDIBELL); Bellvitge University Hospital; Pompeu
   Fabra University; Servicio Navarro de Salud - Osasunbidea
RP Salas-Salvadó, J (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr, Madrid, Spain.; Salas-Salvadó, J (corresponding author), Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Unitat Nutricio, Reus, Spain.; Salas-Salvadó, J (corresponding author), Inst Invest Sanit Pere Virgili IISPV, Reus, Spain.
EM indiradelsocorro.paz@urv.cat; nancy.babio@urv.cat;
   stephanie.nishi@urv.cat; mamartinez@unav.es; dolores.corella@uv.es;
   mfito@imim.es; jalfmtz@unav.es; angelmago13@gmail.com; jwarnberg@uma.es;
   vioque@umh.es; dora.romaguera@isglobal.org; md1lomij@uco.es;
   restruch@clinic.cat; fjtinahones@hotmail.com;
   josemanuel.santos.lozano@gmail.com; lluis.serra@ulpgc.es; abueno@ugr.es;
   pep.tur@uib.es; vicente.martin@unileon.es; xpinto@bellvitgehospital.cat;
   mdelgado@ujaen.es; pilar.matia@gmail.com; jovidal@clinic.cat;
   cristina.calderon@fjd.es; lidia.daimiel@imdea.org; eros@clinic.cat;
   ffernandez@bellvitgehospital.cat; etoledo@unav.es;
   cristina.valle@urv.cat; sorli@uv.es; classale@imim.es;
   angarios2004@yahoo.es; aoncina@umh.es; baron@uma.es; mazulet@unav.es;
   elena.rayo@ssib.es; rcasas1@recerca.clinic.cat; estherthca@gmail.com;
   lutojal@hotmail.com; migueldamasf@hotmail.com; mcanela@unav.es;
   sara.delasheras@estudiants.urv.cat; rebeca.fernandez@uv.es;
   ocastaner@imim.es; patricia.pena@imibic.org; sandra.gonzalezp@umh.es;
   pilarbuilc@gmail.com; agoday@psmar.cat; jordi.salas@urv.cat
RI Tejada, Silvia/L-7297-2014; Palacios, Sandra/AAA-9585-2021; Vioque,
   Jesus/A-1066-2008; Ruiz-Canela, Miguel/JYP-1794-2024; Lopez-Miranda,
   Jose/Y-8306-2019; Vidal, Josep/MIK-6936-2025; Daimiel-Ruiz,
   Lidia/M-7779-2014; Lassale, Camille/ABE-7813-2020; Pintó,
   Xavier/AGI-4297-2022; Castaner, Olga/F-1533-2013; Tur,
   Josep/AAE-5748-2020; Rodríguez, Miguel/KCZ-1828-2024; Paz-Graniel,
   Indira/ABH-2583-2020; Fernandez-Carrion, Rebeca/AAA-5713-2019; López,
   Francisco/O-9249-2016; Bueno-Cavanillas, Aurora/O-1513-2015; Babio,
   Nancy/AAN-2715-2020; Tinahones, Francisco/AAB-2882-2020; Oncina Canovas,
   Alejandro/KOD-0906-2024; Toledo, Estefania/H-6211-2014; ALONSO GOMEZ,
   ANGEL/HLG-2476-2023; Zulet, M./H-1317-2017; Martinez-Gonzalez,
   Miguel/AAE-7669-2019; Sorlí, José/L-8758-2014; Serra-Majem,
   Lluis/I-6708-2019; Estruch, Ramon/AAZ-3723-2020; Romaguera,
   Dora/ABE-7004-2020; Corella, Dolores/L-9888-2014; Martínez,
   J./K-8709-2014; Nishi, Stephanie/GSN-1143-2022; Casas,
   Rosa/ABD-1915-2020; Fito Colomer, Montse/C-1822-2012; Martin,
   Vicente/A-1597-2008; FERNANDEZ-ARANDA, FERNANDO/L-9762-2014;
   Salas-Salvado, Jordi/C-7229-2017
OI Fito Colomer, Montse/0000-0002-1817-483X; Martin,
   Vicente/0000-0003-0552-2804; Nishi, Stephanie/0000-0002-7878-5368;
   Oncina Canovas, Alejandro/0000-0003-4652-0565; Lassale,
   Camille/0000-0002-9340-2708; Tinahones, Francisco J/0000-0001-6871-4403;
   FERNANDEZ-ARANDA, FERNANDO/0000-0002-2968-9898; BABIO SANCHEZ,
   NANCY/0000-0003-3527-5277; Salas-Salvado, Jordi/0000-0003-2700-7459;
   Sorli, Jose V/0000-0002-0130-2006; Lopez-Miranda,
   Jose/0000-0002-8844-0718; Paz Graniel, Indira/0000-0002-3204-6877; Valle
   Hita, Cristina/0000-0001-5423-7466; de las Heras Delgado,
   Sara/0000-0002-3439-5712
FU European Regional Development Fund [PI13/00673, PI13/00492, PI13/00272,
   PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090,
   PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206,
   PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471];
   European Research Council [340918]; Recercaixa [2013ACUP00194];
   Consejeria de Salud de la Junta de Andalucia [PI0458/2013, PS0358/2016,
   PI0137/2018]; Junta de Andalucia [MFE-171207]; Department of Health of
   the Junta de Andalucia; ICREA; CIBER Fisiopatologia de la Obesidad y
   Nutricion (CIBEROBN); MICIN/AEI/FEDER, UE; Instituto de Salud Carlos III
   (ISCIII), through the Fondo de Investigacion para la Salud (FIS)
   [SLT006/17/00246]; Canadian Institutes of Health Research (CIHR);
   Especial Action Project entitled: Implementacion y evaluacion de una
   intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus
   [CEX2021-001234-M]; Generalitat de Catalunya; Fundacion Francisco Soria
   Melguizo
FX This work was supported by the official Spanish Institutions for funding
   scientific biomedical research, CIBER Fisiopatologia de la Obesidad y
   Nutricion (CIBEROBN) and Instituto de Salud Carlos III (ISCIII), through
   the Fondo de Investigacion para la Salud (FIS), which is cofunded by the
   European Regional Development Fund (six coordinated FIS projects led by
   JS-S and JVi, including the following projects: PI13/00673, PI13/00492,
   PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728,
   PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696,
   PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728,
   PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501,
   PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764,
   PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532,
   PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957,
   PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226,
   PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532,
   PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158); the
   Especial Action Project entitled: Implementacion y evaluacion de una
   intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus
   grant to JS-S; the European Research Council (Advanced Research Grant
   2014-2019; agreement #340918) granted to MAM-G.; the Recercaixa (number
   2013ACUP00194) grant to JS-S; grants from the Consejeria de Salud de la
   Junta de Andalucia (PI0458/2013, PS0358/2016, PI0137/2018); the
   PROMETEO/2017/017 grant from the Junta de Andalucia; the SEMERGEN grant
   and funds from the Junta de Andalucia (CB06/03). Study resulting from
   the SLT006/17/00246 grant, funded by the Department of Health of the
   Junta de Andalucia by the call "Accio instrumental de programes de
   recerca orientats en l'ambit de la recerca i la innovacio en salut." We
   thank the CERCA Programme/Generalitat de Catalunya for their
   institutional support. We thank Fundacion Francisco Soria Melguizo for
   the financial support. Jordi Salas-Salvado is partially supported by
   ICREA under the ICREA Academia program. The Institut de Recerca en
   Nutricio i Seguretat Alimentaria (INSA-UB), University of Barcelona,
   Barcelona, Spain, is recognized as a Maria de Maeztu Unit of Excellence
   grant CEX2021-001234-M) funded by MICIN/AEI/FEDER, UE. S.K.N. is
   supported by a postdoctoral fellowship from the Canadian Institutes of
   Health Research (CIHR, MFE-171207). C.V-H. receives a predoctoral grant
   from the Generalitat de Catalunya (2022 FI_B100108).
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   [Anonymous], 2020, Boletin Oficial del Estado, P25390
   Association AP, 2013, Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
   Benke C, 2020, PSYCHIAT RES, V293, DOI 10.1016/j.psychres.2020.113462
   Bonati M, 2022, EPIDEMIOL PSYCH SCI, V31, DOI 10.1017/S2045796022000051
   Castellvi Obiols P., 2021, IMPACT COVID 19 PHYS
   Centers for DiseaseControl and Prevention, 2021, COVID 19 RISKS VACC
   Czeisler MÉ, 2020, MMWR-MORBID MORTAL W, V69, P1049, DOI [10.15585/mmwr.mm6932a1, 10.1101/2020.04.22.20076141v1]
   de Espana G., 2020, B ESTADO, V53
   de Sanidad M., REAL DECRETO 115 202
   Ding KL, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18052686
   Hamm ME, 2020, AM J GERIAT PSYCHIAT, V28, P924, DOI 10.1016/j.jagp.2020.06.013
   Martínez-González MA, 2019, INT J EPIDEMIOL, V48, P387, DOI 10.1093/ije/dyy225
   Ministerio de Sanidad Gobierno de Espana., 2020, B ESTADO, V53, P1689
   Molina L, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0168148
   Salas-Salvado J., 2018, DIABETES CARE, V42
   Sanchez-Villegas A, 2013, BMC MED, V11, DOI [10.1186/1741-7015-11-3, 10.1186/1741-7015-11-208]
   Santomauro DF, 2021, LANCET, V398, P1700, DOI 10.1016/S0140-6736(21)02143-7
   Sanz J., 2003, Clinica y Salud, V14, P249, DOI DOI 10.7334/PSICOTHEMA2012.96
   Schröder H, 2021, CLIN NUTR, V40, P4971, DOI 10.1016/j.clnu.2021.06.030
   Sun Y, 2023, BMJ-BRIT MED J, V380, DOI 10.1136/bmj-2022-074224
   Vahia IV, 2020, JAMA-J AM MED ASSOC, V324, P2253, DOI 10.1001/jama.2020.21753
   van Tilburg TG, 2021, J GERONTOL B-PSYCHOL, V76, pE249, DOI 10.1093/geronb/gbaa111
   Webb L, 2021, J PSYCHIATR MENT HLT, V28, P300, DOI 10.1111/jpm.12644
   World Health Organization, 2017, WHOMSDMER20172
   World Health Organization, 2022, Azov Media
NR 26
TC 1
Z9 1
U1 1
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1091-4269
EI 1520-6394
J9 DEPRESS ANXIETY
JI Depress. Anxiety
PD JUL 14
PY 2023
VL 2023
AR 6765950
DI 10.1155/2023/6765950
PG 9
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA N1GX8
UT WOS:001034593000001
PM 40224603
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Xiao, LH
   Sun, Y
   Tsao, R
AF Xiao, Lihua
   Sun, Yong
   Tsao, Rong
TI Paradigm Shift in Phytochemicals Research: Evolution from Antioxidant
   Capacity to Anti-Inflammatory Effect and to Roles in Gut Health and
   Metabolic Syndrome
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE food bioactives; phytochemicals; polyphenolics; carotenoids;
   antioxidant; anti-inflammation; gut microbiota; immune response;
   metabolic syndrome
ID NF-KAPPA-B; CHAIN FATTY-ACIDS; LOW-GRADE INFLAMMATION; VULGA L. MILK;
   OXIDATIVE STRESS; IN-VITRO; PHENOLIC-COMPOUNDS; POLYPHENOL METABOLITES;
   NATURAL-PRODUCTS; ADIPOSE-TISSUE
AB Food bioactive components, particularly phytochemicals with antioxidant capacity, have been extensively studied over the past two decades. However, as new analytical and molecular biological tools advance, antioxidants related research has undergone significant paradigm shifts. This review is a high-level overview of the evolution of phytochemical antioxidants research. Early research used chemical models to assess the antioxidant capacity of different phytochemicals, which provided important information about the health potential, but the results were overused and misinterpreted despite the lack of biological relevance (Antioxidants v1.0). This led to findings in the anti-inflammatory properties and modulatory effects of cell signaling of phytochemicals (Antioxidants v2.0). Recent advances in the role of diet in modulating gut microbiota have suggested a new phase of food bioactives research along the phytochemicals-gut microbiota-intestinal metabolites-low-grade inflammation-metabolic syndrome axis (Antioxidants v3.0). Polyphenols and carotenoids were discussed in-depth, and future research directions were also
C1 [Xiao, Lihua; Sun, Yong] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China.
   [Tsao, Rong] Agr & Agrifood Canada, Guelph Res & Dev Ctr, Guelph, ON N1G 5C9, Canada.
C3 Nanchang University; Agriculture & Agri Food Canada
RP Tsao, R (corresponding author), Agr & Agrifood Canada, Guelph Res & Dev Ctr, Guelph, ON N1G 5C9, Canada.
EM Rong.Cao@agr.gc.ca
RI Tsao, Rong/I-3096-2014
OI Sun, Yong/0000-0003-2324-7180; Tsao, Rong/0000-0001-6537-1820; Xiao,
   Lihua/0009-0003-5514-452X
FU Agriculture & Agri-Food Canada [J-002252]; National Natural Science
   Foundation of China [82060781]; China Postdoctoral Science Foundation
   [2020M671975]
FX This study was supported by the A-Base project (#J-002252) of
   Agriculture & Agri-Food Canada, the National Natural Science Foundation
   of China (No. 82060781) , and the China Postdoctoral Science Foundation
   (No. 2020M671975) .
CR Agus A, 2021, GUT, V70, P1174, DOI 10.1136/gutjnl-2020-323071
   Ahonen TM, 2012, NUTR METAB CARDIOVAS, V22, P285, DOI 10.1016/j.numecd.2010.07.001
   Al-Lahham S, 2012, EUR J CLIN INVEST, V42, P357, DOI 10.1111/j.1365-2362.2011.02590.x
   Alves-Santos AM, 2020, J FUNCT FOODS, V74, DOI 10.1016/j.jff.2020.104169
   Amorati R, 2015, FREE RADICAL RES, V49, P633, DOI 10.3109/10715762.2014.996146
   Andersen CJ, 2016, ADV NUTR, V7, P66, DOI 10.3945/an.115.010207
   Apak R, 2005, FREE RADICAL RES, V39, P949, DOI 10.1080/10715760500210145
   Apak R, 2007, MOLECULES, V12, P1496, DOI 10.3390/12071496
   Apak R, 2013, PURE APPL CHEM, V85, P957, DOI 10.1351/PAC-REP-12-07-15
   Aravind SM, 2021, FOOD RES INT, V142, DOI 10.1016/j.foodres.2021.110189
   Arnao MB, 1996, ANAL BIOCHEM, V236, P255, DOI 10.1006/abio.1996.0164
   Aruna R, 2014, MOL CELL BIOCHEM, V396, P269, DOI 10.1007/s11010-014-2162-8
   Ashaolu TJ, 2020, APPL MICROBIOL BIOT, V104, P9009, DOI 10.1007/s00253-020-10799-2
   Bäckhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Badarinath AV., 2010, Intl J Pharm Tech Res, V2, P1276
   Baxter NT, 2019, MBIO, V10, DOI [10.1128/mBio.02566-18, 10.1128/mbio.02566-18]
   Benzie IFF, 1996, ANAL BIOCHEM, V239, P70, DOI 10.1006/abio.1996.0292
   Sadeer NB, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9080709
   Brown AJ, 2003, J BIOL CHEM, V278, P11312, DOI 10.1074/jbc.M211609200
   Burcelin R, 2016, MOL METAB, V5, P771, DOI 10.1016/j.molmet.2016.05.016
   Calder PC, 2011, BRIT J NUTR, V106, pS1, DOI 10.1017/S0007114511005460
   Cândido FG, 2018, INT J FOOD SCI NUTR, V69, P125, DOI 10.1080/09637486.2017.1343286
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cano A, 2000, REDOX REP, V5, P365, DOI 10.1179/135100000101535933
   Cano A, 2018, FUNCT FOOD SCI TECHN, P117
   CAO GH, 1993, FREE RADICAL BIO MED, V14, P303, DOI 10.1016/0891-5849(93)90027-R
   Carbonell-Capella JM, 2014, COMPR REV FOOD SCI F, V13, P155, DOI 10.1111/1541-4337.12049
   Cardona F, 2013, J NUTR BIOCHEM, V24, P1415, DOI 10.1016/j.jnutbio.2013.05.001
   Cardozo LFMF, 2013, BIOCHIMIE, V95, P1525, DOI 10.1016/j.biochi.2013.04.012
   Catrysse L, 2017, TRENDS CELL BIOL, V27, P417, DOI 10.1016/j.tcb.2017.01.006
   Chaplin A, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111651
   Chen SY, 2018, FASEB J, V32, P1139, DOI [10.1096/fj.201700741RR, 10.1096/fj.201700741rr]
   Chen YH, 2021, J AGR FOOD CHEM, V69, P1513, DOI 10.1021/acs.jafc.0c06934
   Chen YH, 2019, J FUNCT FOODS, V53, P125, DOI 10.1016/j.jff.2018.12.013
   Cox AJ, 2015, LANCET DIABETES ENDO, V3, P207, DOI 10.1016/S2213-8587(14)70134-2
   Daily JW, 2021, BIOFACTORS, V47, P218, DOI 10.1002/biof.1703
   Daniells S., 2007, NUTRAINGREDIENTS
   de León-Rodríguez MDP, 2019, CRIT REV FOOD SCI, V59, P3648, DOI 10.1080/10408398.2018.1506734
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   DELRIO LA, 1992, FREE RADICAL BIO MED, V13, P557, DOI 10.1016/0891-5849(92)90150-F
   Dong RH, 2020, FOOD FUNCT, V11, P6652, DOI [10.1039/d0fo00975j, 10.1039/D0FO00975J]
   Donohoe DR, 2011, CELL METAB, V13, P517, DOI 10.1016/j.cmet.2011.02.018
   Edwards CA, 2017, NUTR BULL, V42, P356, DOI 10.1111/nbu.12296
   Eggler Aimee L, 2013, Recent Adv Phytochem, V43, P121
   Ehrhart-Bornstein M, 2003, P NATL ACAD SCI USA, V100, P14211, DOI 10.1073/pnas.2336140100
   Esfanjani AF, 2018, TRENDS FOOD SCI TECH, V76, P56, DOI 10.1016/j.tifs.2018.04.002
   Farruggia C, 2018, J NUTR BIOCHEM, V62, P202, DOI 10.1016/j.jnutbio.2018.09.005
   Frank J, 2006, J LIPID RES, V47, P2718, DOI 10.1194/jlr.M600291-JLR200
   Furet JP, 2010, DIABETES, V59, P3049, DOI 10.2337/db10-0253
   Furger C, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10060944
   Gao ZG, 2009, DIABETES, V58, P1509, DOI 10.2337/db08-1637
   Gerardi G, 2019, J FUNCT FOODS, V58, P255, DOI 10.1016/j.jff.2019.05.003
   Ghizzoni M, 2011, DRUG DISCOV TODAY, V16, P504, DOI 10.1016/j.drudis.2011.03.009
   Gibson GR, 2017, NAT REV GASTRO HEPAT, V14, P491, DOI 10.1038/nrgastro.2017.75
   Gironde C, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9060471
   Granato D, 2018, FOOD CHEM, V264, P471, DOI 10.1016/j.foodchem.2018.04.012
   Grivennikov SI, 2010, CELL, V140, P883, DOI 10.1016/j.cell.2010.01.025
   Grotto D, 2009, QUIM NOVA, V32, P169, DOI 10.1590/S0100-40422009000100032
   Guilherme A, 2008, NAT REV MOL CELL BIO, V9, P367, DOI 10.1038/nrm2391
   Guo BB, 2019, FOOD FUNCT, V10, P5644, DOI 10.1039/c9fo01018a
   Guo LX, 2019, PHARMACOL RES, V149, DOI 10.1016/j.phrs.2019.104459
   Guo R, 2014, MED SCI MONIT BASIC, V20, P82, DOI 10.12659/MSMBR.890858
   Guo ZT, 2021, SYST MICROBIOL BIOM, V1, P363, DOI 10.1007/s43393-021-00035-x
   Hadad N, 2012, FREE RADICAL BIO MED, V53, P1381, DOI 10.1016/j.freeradbiomed.2012.07.078
   Halliwell B, 1996, ANNU REV NUTR, V16, P33, DOI 10.1146/annurev.nu.16.070196.000341
   Han B, 2021, FOOD RES INT, V141, DOI 10.1016/j.foodres.2021.110147
   Han JH, 2019, MAR DRUGS, V17, DOI 10.3390/md17020123
   Heimann E, 2016, ADIPOCYTE, V5, P359, DOI 10.1080/21623945.2016.1252011
   Herrema H, 2020, DIABETOLOGIA, V63, P2533, DOI 10.1007/s00125-020-05268-4
   Himaya SWA, 2012, TOXICOL IN VITRO, V26, P878, DOI 10.1016/j.tiv.2012.04.022
   Ho L, 2019, J NUTR BIOCHEM, V64, P170, DOI 10.1016/j.jnutbio.2018.10.019
   Honzel D, 2008, J AGR FOOD CHEM, V56, P8319, DOI 10.1021/jf800401d
   Hotamisligil GS, 2008, NAT REV IMMUNOL, V8, P923, DOI 10.1038/nri2449
   Huang DJ, 2005, J AGR FOOD CHEM, V53, P1841, DOI 10.1021/jf030723c
   Huda-Faujan N, 2010, Open Biochem J, V4, P53, DOI 10.2174/1874091X01004010053
   Husain I, 2021, FOOD FRONTIERS, V2, P449, DOI 10.1002/fft2.110
   Hussain T, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/7432797
   Iino C, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020433
   Jayachandran M, 2018, J NUTR BIOCHEM, V61, P101, DOI 10.1016/j.jnutbio.2018.06.010
   Jhang JJ, 2015, J AGR FOOD CHEM, V63, P7343, DOI 10.1021/acs.jafc.5b02605
   Kawabata K, 2019, MOLECULES, V24, DOI 10.3390/molecules24020370
   Kobayashi Y, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-13368-2
   Koudoufio M, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9100982
   Kumar B, 2008, CANCER RES, V68, P1777, DOI 10.1158/0008-5472.CAN-07-5259
   Lamuel-Raventos RM, 2017, CRIT REV FOOD SCI, V57, P3154, DOI 10.1080/10408398.2015.1096763
   Larrosa M, 2009, MOL NUTR FOOD RES, V53, P1044, DOI 10.1002/mnfr.200800446
   Larrosa M, 2009, J AGR FOOD CHEM, V57, P2211, DOI 10.1021/jf803638d
   Lee SJ, 2003, MOL CELLS, V16, P97
   Leung PHM, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.01317
   Li HY, 2014, FOOD CHEM, V159, P353, DOI 10.1016/j.foodchem.2014.03.023
   Li HY, 2011, J AGR FOOD CHEM, V59, P11803, DOI 10.1021/jf202364v
   Li RN, 2019, ANIM SCI J, V90, P140, DOI 10.1111/asj.13108
   Liguori I, 2018, CLIN INTERV AGING, V13, P757, DOI 10.2147/CIA.S158513
   Liu HX, 2020, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.00036
   Liu HL, 2018, NUTRIENTS, V10, DOI 10.3390/nu10091298
   Liu JK, 2015, BRAIN RES, V1610, P1, DOI 10.1016/j.brainres.2015.03.044
   Liu RH, 2013, ADV NUTR, V4, p384S, DOI 10.3945/an.112.003517
   López-Alarcón C, 2013, ANAL CHIM ACTA, V763, P1, DOI 10.1016/j.aca.2012.11.051
   López-Jaramillo P, 2014, HORM MOL BIOL CLIN I, V18, P37, DOI 10.1515/hmbci-2013-0053
   Luca SV, 2020, CRIT REV FOOD SCI, V60, P626, DOI 10.1080/10408398.2018.1546669
   Luo ZC, 2020, PHARMACOL RES, V160, DOI 10.1016/j.phrs.2020.105088
   MacKellar J, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008197
   Martín AR, 2004, BIOCHEM PHARMACOL, V67, P1399, DOI 10.1016/j.bcp.2003.12.024
   Mirzaei R, 2021, BIOMED PHARMACOTHER, V139, DOI 10.1016/j.biopha.2021.111661
   Moorthy M, 2021, FOODS, V10, DOI 10.3390/foods10020299
   Morais CA, 2016, J NUTR BIOCHEM, V33, P1, DOI 10.1016/j.jnutbio.2015.11.008
   Mosele JI, 2015, MOLECULES, V20, P17429, DOI 10.3390/molecules200917429
   Na JY, 2016, BIOCHEM BIOPH RES CO, V473, P1301, DOI 10.1016/j.bbrc.2016.04.064
   Nwachukwu ID, 2021, MOLECULES, V26, DOI 10.3390/molecules26164865
   Overby HB, 2021, CURR HYPERTENS REP, V23, DOI 10.1007/s11906-020-01125-2
   Pan FG, 2015, INT J FOOD SCI NUTR, V66, P680, DOI 10.3109/09637486.2015.1077792
   Parkar SG, 2013, ANAEROBE, V23, P12, DOI 10.1016/j.anaerobe.2013.07.009
   Parker A, 2020, GUT MICROBES, V11, P135, DOI 10.1080/19490976.2019.1638722
   Pisoschi AM, 2015, EUR J MED CHEM, V97, P55, DOI 10.1016/j.ejmech.2015.04.040
   PIZZINO G, 2017, OXID MED CELL LONGEV, V2017, DOI DOI 10.1155/2017/8416763
   Popovic BM, 2012, FOOD CHEM, V134, P734, DOI 10.1016/j.foodchem.2012.02.170
   Poyton RO, 2009, TRENDS ENDOCRIN MET, V20, P332, DOI 10.1016/j.tem.2009.04.001
   Reuter S, 2010, FREE RADICAL BIO MED, V49, P1603, DOI 10.1016/j.freeradbiomed.2010.09.006
   Ríos-Arrabal S, 2013, SPRINGERPLUS, V2, DOI 10.1186/2193-1801-2-404
   Rios-Covian D, 2020, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.00973
   Rivera-Piza A, 2020, APPL BIOL CHEM, V63
   Romulo Andreas, 2020, IOP Conference Series: Earth and Environmental Science, V426, DOI 10.1088/1755-1315/426/1/012177
   Ruhee RT, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9060521
   Russell WR, 2013, CURR OPIN MICROBIOL, V16, P246, DOI 10.1016/j.mib.2013.07.002
   Salzano S, 2014, P NATL ACAD SCI USA, V111, P12157, DOI 10.1073/pnas.1401712111
   Sartipy P, 2003, P NATL ACAD SCI USA, V100, P7265, DOI 10.1073/pnas.1133870100
   Saura-Calixto F, 2010, MOL NUTR FOOD RES, V54, P939, DOI 10.1002/mnfr.200900276
   Scalbert A, 2005, AM J CLIN NUTR, V81, p215S, DOI 10.1093/ajcn/81.1.215S
   Scalbert A, 2002, BIOMED PHARMACOTHER, V56, P276, DOI 10.1016/S0753-3322(02)00205-6
   Schaich KM, 2015, J FUNCT FOODS, V14, P111, DOI 10.1016/j.jff.2015.01.043
   Schilderink R, 2016, AM J PHYSIOL-GASTR L, V310, pG1138, DOI 10.1152/ajpgi.00411.2015
   Sessa M, 2014, FOOD CHEM, V147, P42, DOI 10.1016/j.foodchem.2013.09.088
   Sessa M, 2011, J AGR FOOD CHEM, V59, P12352, DOI 10.1021/jf2031346
   Sharma Renu, 2010, J Biomed Biotechnol, V2010, P305879, DOI 10.1155/2010/305879
   Song LH, 2020, FOOD FUNCT, V11, P977, DOI [10.1039/C9FO01570A, 10.1039/c9fo01570a]
   Stahl W, 2003, MOL ASPECTS MED, V24, P345, DOI 10.1016/S0098-2997(03)00030-X
   Sun Y, 2021, MIN PROC EXT MET-UK, V130, P10, DOI 10.1080/25726641.2018.1505210
   Surmi BK, 2008, FUTURE LIPIDOL, V3, P545, DOI 10.2217/17460875.3.5.545
   Takagaki A, 2015, BIOL PHARM BULL, V38, P789, DOI 10.1248/bpb.b14-00813
   Tan Bee Ling, 2018, Oxid Med Cell Longev, V2018, P9719584, DOI 10.1155/2018/9719584
   Truong VL, 2021, J MED FOOD, V24, P786, DOI 10.1089/jmf.2021.K.0003
   Tsao R., 2015, Handbook of antioxidants for food preservation. Woodhead Publishing Series in Food Science, Technology and Nutrition, P335, DOI DOI 10.1016/B978-1-78242-089-7.00013-0
   Tsao R, 2010, NUTRIENTS, V2, P1231, DOI 10.3390/nu2121231
   Tsao Rong Tsao Rong, 2005, Journal of Food, Agriculture & Environment, V3, P10
   Umbreen H., 2021, METABOLISM CAROTENOI, P421
   Unno T, 2015, J AGR FOOD CHEM, V63, P7952, DOI 10.1021/acs.jafc.5b02649
   von Lintig J, 2020, BBA-MOL CELL BIOL L, V1865, DOI 10.1016/j.bbalip.2019.158580
   Waldecker M, 2008, J NUTR BIOCHEM, V19, P587, DOI 10.1016/j.jnutbio.2007.08.002
   Wang CH, 2004, INT IMMUNOPHARMACOL, V4, P1039, DOI 10.1016/j.intimp.2004.04.005
   Wang CZ, 2015, INT J ONCOL, V47, P1749, DOI 10.3892/ijo.2015.3173
   Wang H, 1999, FREE RADICAL BIO MED, V27, P612, DOI 10.1016/S0891-5849(99)00107-0
   Wang H, 1996, J AGR FOOD CHEM, V44, P701, DOI 10.1021/jf950579y
   Wang JH, 2019, MAR DRUGS, V17, DOI 10.3390/md17060337
   Wang S, 2011, J AGR FOOD CHEM, V59, P960, DOI 10.1021/jf1040977
   Wang Y, 2022, CRIT REV FOOD SCI, V62, P5140, DOI 10.1080/10408398.2021.1882381
   Weaver CM, 2014, ADV NUTR, V5, p306S, DOI 10.3945/an.113.005124
   Wiegman CH, 2015, J ALLERGY CLIN IMMUN, V136, P769, DOI 10.1016/j.jaci.2015.01.046
   Williams RJ, 2004, FREE RADICAL BIO MED, V36, P838, DOI 10.1016/j.freeradbiomed.2004.01.001
   Wolfe KL, 2007, J AGR FOOD CHEM, V55, P8896, DOI 10.1021/jf0715166
   Wood R., 2005, ENCY HUMAN NUTR, V2nd
   Wu M, 2021, CRIT REV FOOD SCI, V61, P2175, DOI 10.1080/10408398.2020.1773390
   Wu SJ, 2021, TRENDS FOOD SCI TECH, V108, P164, DOI 10.1016/j.tifs.2020.12.019
   Wu W, 2017, MUCOSAL IMMUNOL, V10, P946, DOI 10.1038/mi.2016.114
   Xia H, 2018, CANCER PREV RES, V11, P797, DOI 10.1158/1940-6207.CAPR-18-0188
   Xiao ZJ, 2014, PLOS ONE, V9, DOI [10.1371/journal.pone.0101251, 10.1371/journal.pone.0107072]
   Xu Y, 2020, THERANOSTICS, V10, P11302, DOI 10.7150/thno.47746
   Yang C., 2020, Journal of Food Bioactives, V10, P32, DOI [10.31665/jfb.2020.10229, DOI 10.31665/JFB.2020.10229, 10.31665/JFB.2020.10229]
   Yang C, 2019, J AGR FOOD CHEM, V67, P6222, DOI 10.1021/acs.jafc.9b02102
   Yang C, 2018, FUNCT FOOD SCI TECHN, P165
   Ye J, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-12252-3
   Yin HY, 2011, CHEM REV, V111, P5944, DOI 10.1021/cr200084z
   Yoo JY, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8101587
   Zhang B, 2020, TRENDS FOOD SCI TECH, V105, P347, DOI 10.1016/j.tifs.2020.09.029
   Zhang C, 2020, FOOD FUNCT, V11, P1946, DOI [10.1039/C9FO02961C, 10.1039/c9fo02961c]
   Zhang H, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600928
   Zhang H, 2016, CURR OPIN FOOD SCI, V8, P33, DOI 10.1016/j.cofs.2016.02.002
   Zhao L, 2011, NUTR REV, V69, P310, DOI 10.1111/j.1753-4887.2011.00394.x
   Zheng SL, 2021, FOOD RES INT, V139, DOI 10.1016/j.foodres.2020.109833
   Zulueta A, 2009, FOOD CHEM, V114, P310, DOI 10.1016/j.foodchem.2008.09.033
NR 180
TC 22
Z9 22
U1 2
U2 51
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD JUL 20
PY 2022
VL 70
IS 28
BP 8551
EP 8568
DI 10.1021/acs.jafc.2c02326
EA JUL 2022
PG 18
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA 3D8CP
UT WOS:000829233000001
PM 35793510
DA 2025-06-11
ER

PT J
AU Lin, CH
   Chiang, SL
   Heitkemper, MM
   Hung, YJ
   Lee, MS
   Tzeng, WC
   Chiang, LC
AF Lin, Chia-Huei
   Chiang, Shang-Lin
   Heitkemper, Margaret McLean
   Hung, Yi-Jen
   Lee, Meei-Shyuan
   Tzeng, Wen-Chii
   Chiang, Li-Chi
TI Effects of telephone-based motivational interviewing in lifestyle
   modification program on reducing metabolic risks in middle-aged and
   older women with metabolic syndrome: A randomized controlled trial
SO INTERNATIONAL JOURNAL OF NURSING STUDIES
LA English
DT Article
DE Lifestyle modification; Metabolic syndrome; Motivational interviewing;
   Physical activity; Randomized controlled trial; Telephone; Women
ID PROMOTE PHYSICAL-ACTIVITY; ACTIVITY INTERVENTION; OXIDATIVE STRESS;
   NATIONAL-HEALTH; PREVALENCE; EXERCISE; ADULTS; METAANALYSIS; POPULATION;
   DIET
AB Background: Lifestyle modification is often difficult for middle-aged and older women living in the community who are at high risk of physical inactivity and metabolic syndrome.
   Objectives: To examine the effects of telephone-based motivational interviewing in a 12-week lifestyle modification program on physical activity, MetS, metabolic risks (fasting plasma glucose, blood pressure, triglyceride, high-density lipoprotein, and central obesity), and the number of metabolic risks in community-living middle-aged and older women diagnosed with metabolic syndrome.
   Research design and method: A randomized controlled trial was conducted. Recruited were 328 middle-aged and older women from a community health center in Taiwan. Eligible women medically diagnosed with metabolic syndrome (n = 115) were randomly assigned to one of three groups: The experimental group received an individualized telephone delivered lifestyle modification program that included motivational interviewing delivered by an experienced nurse. The brief group received a single brief lifestyle modification counseling session with a brochure. The usual care group received standard care. Physical activity was assessed with the International Physical Activity Questionnaire and metabolic risks were determined by serum markers and anthropometric measures at pre- and post-intervention. One hundred women completed the study and an intention-to treat analysis was performed. Generalized estimating equations were used to examine the intervention effects.
   Results: Women in the experimental group increased physical activity from 1609 to 1892 MET-min/week (beta=846, p=.01), reduced the percentage of diagnosed with metabolic syndrome to 81.6% (beta=-0.17, p=.003), and decreased the number of metabolic risks from 4.0 to 3.6 (beta=-0.50, p<.001), compared to the usual care group (4.4-4.6). There was not a reduction in the percentage of diagnosed with metabolic syndrome in the brief group, but they had fewer metabolic risks after 12 weeks (mean=4.0 vs. 4.6, (beta=-0.2, p=.02) compared to the usual care group.
   Conclusions: Motivational interviewing as a component of an individualized physical activity and lifestyle modification program has positive benefit in reducing metabolic risks in middle-aged and older women. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Lin, Chia-Huei] Natl Def Med Ctr, Sch Nursing, Triserv Gen Hosp, Dept Nursing, Taipei, Taiwan.
   [Chiang, Shang-Lin] Natl Def Med Ctr, Sch Med, Triserv Gen Hosp, Dept Phys Med & Rehabil, Taipei, Taiwan.
   [Heitkemper, Margaret McLean] Univ Washington, Sch Med, Div Gastroenterol, Dept Biobehav Nursing & Hlth Syst, Seattle, WA 98195 USA.
   [Hung, Yi-Jen] Natl Def Med Ctr, Sch Med, Triserv Gen Hosp, Div Endocrinol & Metab, Taipei, Taiwan.
   [Lee, Meei-Shyuan] Natl Def Med Ctr, Sch Publ Hlth, Taipei, Taiwan.
   [Lee, Meei-Shyuan; Chiang, Li-Chi] Natl Def Med Ctr, Grad Inst Med Sci, Taipei, Taiwan.
   [Tzeng, Wen-Chii; Chiang, Li-Chi] Natl Def Med Ctr, Sch Nursing, Taipei, Taiwan.
   [Chiang, Li-Chi] China Med Univ, Taipei, Taiwan.
   [Chiang, Li-Chi] Natl Def Med Ctr, Sch Nursing, Taichung, Taiwan.
   [Chiang, Li-Chi] Natl Def Med Ctr, Grad Inst Med Sci, Taichung, Taiwan.
   [Chiang, Li-Chi] China Med Univ, Taichung, Taiwan.
C3 Tri-Service General Hospital; National Defense Medical Center;
   Tri-Service General Hospital; National Defense Medical Center;
   University of Washington; University of Washington Seattle; Tri-Service
   General Hospital; National Defense Medical Center; National Defense
   Medical Center; National Defense Medical Center; National Defense
   Medical Center; China Medical University Taiwan; National Defense
   Medical Center; National Defense Medical Center; China Medical
   University Taiwan
RP Chiang, LC (corresponding author), Sch Nursing, 161 Sec 6,Mingchuan E Rd, Taipei 114, Taiwan.
EM lichichiang@gmail.com
RI Lin, Chia-Huei/GLQ-5499-2022; Tzeng, Wen-Chii/M-4214-2014; Chiang,
   Li-Chi/AAW-9661-2020
OI Tzeng, Wen-Chii/0000-0002-4205-896X; Lin, Chia-Huei/0000-0002-5557-9668;
   Chiang, Li-Chi/0000-0002-6383-7495; Lin, Chia-Huei/0000-0003-3751-602X
FU Tri-Service General Hospital, Taipei, Taiwan [TSGH-C102-138]
FX This study was funded by the Tri-Service General Hospital
   (TSGH-C102-138), Taipei, Taiwan.
CR Al-Naimi S, 2004, CHRONOBIOL INT, V21, P937, DOI 10.1081/CBI-200037171
   American College of Sports Medicine [ACSM], 2013, ACSMS GUIDELINES EXE
   [Anonymous], TEL NETW
   [Anonymous], 2014, The Millennium Development Goals Report
   [Anonymous], PHYS ACT WOM
   [Anonymous], PUBLIC HEALTH NUTR
   [Anonymous], 2009, Motivational interviewing: Preparing people for change
   Asemi Z, 2014, NUTRITION, V30, P1287, DOI 10.1016/j.nut.2014.03.008
   Bassi N, 2014, AM J MED, V127, DOI 10.1016/j.amjmed.2014.06.035
   Bauer HM, 2000, J HEALTH CARE POOR U, V11, P33
   Bauman A, 2009, INT J BEHAV NUTR PHY, V6, DOI 10.1186/1479-5868-6-21
   Bennett JA, 2007, NURS RES, V56, P18, DOI 10.1097/00006199-200701000-00003
   Boulé NG, 2001, JAMA-J AM MED ASSOC, V286, P1218, DOI 10.1001/jama.286.10.1218
   Brodie DA, 2005, J ADV NURS, V50, P518, DOI 10.1111/j.1365-2648.2005.03422.x
   Carroll S, 2000, MED SCI SPORT EXER, V32, P2079, DOI 10.1097/00005768-200012000-00018
   Chen AK, 2006, METABOLISM, V55, P871, DOI 10.1016/j.metabol.2006.03.001
   Chen SM, 2012, INT J NURS STUD, V49, P637, DOI 10.1016/j.ijnurstu.2011.11.011
   Chu P, 2016, EUR J PREV CARDIOL, V23, P291, DOI 10.1177/2047487314562741
   COHEN J, 1992, PSYCHOL BULL, V112, P155, DOI 10.1037/0033-2909.112.1.155
   Conn VS, 2003, J AM GERIATR SOC, V51, P1159, DOI 10.1046/j.1532-5415.2003.51365.x
   Connelly J, 2013, DIABETIC MED, V30, P1420, DOI 10.1111/dme.12289
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   Dai DF, 2010, J FORMOS MED ASSOC, V109, P716, DOI 10.1016/S0929-6646(10)60116-7
   Esposito K, 2013, REV ENDOCR METAB DIS, V14, P255, DOI 10.1007/s11154-013-9253-9
   Farinha JB, 2015, SPORTS MED-OPEN, V1, DOI 10.1186/s40798-015-0011-2
   Fitch KV, 2006, AIDS, V20, P1843, DOI 10.1097/01.aids.0000244203.95758.db
   Frugé AD, 2015, NUTR METAB CARDIOVAS, V25, P535, DOI 10.1016/j.numecd.2015.03.006
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Grundy S M., 2005, Cardiol Rev
   Hwang LC, 2006, J FORMOS MED ASSOC, V105, P626, DOI 10.1016/S0929-6646(09)60161-3
   Im EO, 2012, JOGNN-J OBST GYN NEO, V41, P650, DOI 10.1111/j.1552-6909.2012.01392.x
   Kwasniewska M, 2010, PREV MED, V51, P482, DOI 10.1016/j.ypmed.2010.09.003
   Laaksonen DE, 2002, DIABETES CARE, V25, P1612, DOI 10.2337/diacare.25.9.1612
   LIANG KY, 1986, BIOMETRIKA, V73, P13, DOI 10.1093/biomet/73.1.13
   Lilienthal KR, 2014, J AGING PHYS ACTIV, V22, P527, DOI [10.1123/japa.2013-0056, 10.1123/JAPA.2013-0056]
   Lin CH, 2015, J CLIN NURS, V24, P1234, DOI 10.1111/jocn.12683
   Lin CH, 2014, WORLDV EVID-BASED NU, V11, P361, DOI 10.1111/wvn.12069
   Liou Yiing Mei, 2008, J Nurs Res, V16, P252
   Louwagie GMC, 2014, ADDICTION, V109, P1942, DOI 10.1111/add.12671
   Marshall AL, 2003, ANN BEHAV MED, V25, P194, DOI 10.1207/S15324796ABM2503_05
   Mathunjwa ML, 2013, ETHNIC DIS, V23, P143
   McArthur D, 2014, BMC WOMENS HEALTH, V14, DOI 10.1186/1472-6874-14-49
   Mozumdar A, 2011, DIABETES CARE, V34, P216, DOI 10.2337/dc10-0879
   Nanri A, 2012, J OCCUP HEALTH, V54, P215, DOI 10.1539/joh.11-0238-OA
   Oh EG, 2010, METABOLISM, V59, P1035, DOI 10.1016/j.metabol.2009.10.027
   Oh EG, 2008, METABOLISM, V57, P255, DOI 10.1016/j.metabol.2007.09.009
   Oliver I, 2012, IEEE IC COMP COM NET
   Park E, 2015, J CARDIOVASC NURS, V30, P256, DOI 10.1097/JCN.0000000000000142
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Pavey T, 2012, J EPIDEMIOL COMMUN H, V66, P737, DOI 10.1136/jech-2011-200354
   Steeves JA, 2015, MED SCI SPORT EXER, V47, P1635, DOI 10.1249/MSS.0000000000000582
   Touati S, 2011, MED SCI SPORT EXER, V43, P398, DOI 10.1249/MSS.0b013e3181eeb12d
   Wadden TA, 2011, NEW ENGL J MED, V365, P1969, DOI 10.1056/NEJMoa1109220
   Wang WS, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-111
   Wang XW, 2012, J GERONTOL A-BIOL, V67, P417, DOI 10.1093/gerona/glr187
   West DS, 2007, DIABETES CARE, V30, P1081, DOI 10.2337/dc06-1966
   Yamaoka K, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-138
NR 57
TC 38
Z9 43
U1 4
U2 32
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0020-7489
EI 1873-491X
J9 INT J NURS STUD
JI Int. J. Nurs. Stud.
PD AUG
PY 2016
VL 60
BP 12
EP 23
DI 10.1016/j.ijnurstu.2016.03.003
PG 12
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA DQ3KZ
UT WOS:000379102500002
PM 27297365
DA 2025-06-11
ER

PT J
AU Muhic, E
   Mathiesen, S
   Nielsen, MM
   Suominen, A
   Sorensen, K
   Ifversen, M
   Nolsöe, RL
   Pedersen, KM
   Lähteenmäki, P
   Nordestgaard, BG
   Juul, A
   Jahnukainen, K
   Müller, K
AF Muhic, Ena
   Mathiesen, Sidsel
   Nielsen, Malene Mejdahl
   Suominen, Anu
   Sorensen, Kaspar
   Ifversen, Marianne
   Nolsoe, Runa Louise
   Pedersen, Kasper Monsted
   Lahteenmaki, Paivi
   Nordestgaard, Borge Gronne
   Juul, Anders
   Jahnukainen, Kirsi
   Muller, Klaus
TI Metabolic Syndrome in Male Survivors of Pediatric Allogeneic
   Hematopoietic Stem Cell Transplantation: Impact of Total Body
   Irradiation, Low-Grade Inflammation, and Hypogonadism
SO TRANSPLANTATION AND CELLULAR THERAPY
LA English
DT Article
DE Hematopoietic stem cell transplantation; Late effects; Long-term
   survivors; Metabolic syndrome; Pediatrics
ID BONE-MARROW-TRANSPLANTATION; IMPAIRED GLUCOSE-TOLERANCE;
   DIABETES-MELLITUS; CHILDHOOD-CANCER; LONG-TERM; ENDOCRINE; RISK;
   PREVALENCE; DIAGNOSIS; CHILDREN
AB Metabolic syndrome (MetS) is a growing concern in survivors of pediatric hematopoietic stem cell transplantation (HSCT), but little is known about the underlying mechanisms. This study aimed to determine the prevalence and clinical presentation of MetS in male long-term survivors of pediatric HSCT and to investigate predisposing factors, including low-grade inflammation, altered fat distribution, and low testosterone levels. We included 98 survivors age 19 to 47 years at a median follow-up of 18 years (range, 8 to 35 years) after pediatric HSCT. MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria. The prevalence and clinical manifestations of MetS were compared between our cohort and a control group of males from the background population (n = 4767). Fat distribution was assessed by android/gynoid ratio from a whole-body dual-energy X-ray absorptiometry scan. Systemic inflammation was evaluated by IL-6 and high-sensitivity C-reactive protein (hsCRP). Serum testosterone levels were measured in morning samples. The prevalence of MetS was 30%, corresponding to the prevalence in the 50- to 80-year-old males from the background population. In individuals with MetS, hyperglycemia was more frequent in the HSCT survivors compared with age-matched controls with MetS (76% versus 20%; P < .001), whereas hypertension was more dominant in the control group with MetS (69% versus 93%; P = .01). In addition, normal or low body mass index was more commonly observed among HSCT survivors with MetS compared with age-matched controls with MetS (41% versus 11%; P = .002). MetS was more often associated with total body irradiation (TBI) compared with chemotherapy regimens (odds ratio [OR], 4.3; 95% confidence interval [CI], 1.2 to 24.4; P = .02), lower testosterone levels (OR, 5.4; 95% CI, 1.3 to 23.6; P = .02), higher IL-6 levels (OR, 1.8; 95% CI, 1.2 to 2.8; P = .004), and higher hsCRP levels (OR, 1.8; 95% CI, 1.3 to 2.6; P < .001) (estimates per 2-fold increase). In addition, an increased android/gynoid (AG) fat ratio was strongly associated with MetS (OR, 2.1; 95% CI, 1.5 to 2.9; P < .001), even though only 7% of patients met the criteria for increased abdominal circumference. Our results indicate an increased risk of MetS in early adulthood after pediatric HSCT. The clinical manifestations differed from those seen in age-matched controls with MetS, indicating different pathophysiology driven by hyperglycemia, altered fat distribution (despite no clinical abdominal obesity), and low-grade inflammation. Risk factors included TBI-based conditioning and low testosterone levels. These results underline the importance of continuous clinical assessment of the cardiometabolic risk profile and stress the presence of important dissimilarities in the pathophysiology of MetS in HSCT survivors compared with the background population. (c) 2021 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. All rights reserved.
C1 [Muhic, Ena; Mathiesen, Sidsel; Nielsen, Malene Mejdahl; Sorensen, Kaspar; Ifversen, Marianne; Muller, Klaus] Univ Copenhagen, Rigshosp, Dept Pediat & Adolescent Med, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
   [Muhic, Ena; Mathiesen, Sidsel; Nielsen, Malene Mejdahl; Muller, Klaus] Univ Copenhagen, Rigshosp, Inst Inflammat Res, Copenhagen, Denmark.
   [Suominen, Anu; Jahnukainen, Kirsi] Univ Helsinki, Childrens Hosp, Div Hematol Oncol & Stem Cell Transplantat, Helsinki, Finland.
   [Nolsoe, Runa Louise] Helsinki Univ Hosp, Helsinki, Finland.
   [Pedersen, Kasper Monsted; Nordestgaard, Borge Gronne] Univ Copenhagen, Nordsjaellands Hosp, Dept Nephrol & Endocrinol, Hillerod, Denmark.
   [Pedersen, Kasper Monsted; Nordestgaard, Borge Gronne] Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.
   [Lahteenmaki, Paivi] Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland.
   [Lahteenmaki, Paivi] Turku Univ, Turku, Finland.
   [Juul, Anders] Univ Copenhagen, Rigshosp, Dept Growth & Reprod, Copenhagen, Denmark.
   [Jahnukainen, Kirsi] Karolinska Inst, Dept Womens & Childrens Hlth, Nordfertil Res Lab Stockholm, Solna, Sweden.
   [Jahnukainen, Kirsi] Univ Hosp, Solna, Sweden.
   [Muller, Klaus] Univ Copenhagen, Inst Clin Med, Copenhagen, Denmark.
C3 University of Copenhagen; Copenhagen University Hospital;
   Rigshospitalet; University of Copenhagen; Copenhagen University
   Hospital; Rigshospitalet; University of Helsinki; University of
   Helsinki; Helsinki University Central Hospital; University of
   Copenhagen; University of Copenhagen; University of Turku; University of
   Turku; University of Copenhagen; Copenhagen University Hospital;
   Rigshospitalet; Karolinska Institutet; University of Copenhagen
RP Müller, K (corresponding author), Univ Copenhagen, Rigshosp, Dept Pediat & Adolescent Med, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.; Müller, K (corresponding author), Univ Copenhagen, Rigshosp, Inst Inflammat Res, Copenhagen, Denmark.
EM klaus.mueller@regionh.dk
RI Muller, Klaus/JVN-5112-2024; Juul, Anders/F-5864-2013; Nordestgaard,
   Borge/ABF-1310-2020; Ifversen, Marianne/AAN-4016-2021
OI Mejdahl, Malene Asp Bock/0000-0002-2223-4938; Juul,
   Anders/0000-0002-0534-4350; Nordestgaard, Borge/0000-0002-1954-7220
FU Danish Childhood Cancer Foundation [2015-15, 2016-0261]; Rigshospitalet
   Research Foundation; Danish Cancer Society [R165-A10527]; Danish Cancer
   Research Foundation; Dagmar Marshall Foundation; Hartmann Brothers
   Foundation [A30640]; Finnish Cancer Society; Finnish Foundation of
   Pediatric Research; Helsinki University Research Foundation; Swedish
   Childhood Cancer Foundation [PR2017-0037, TJ2015-0046]; Swedish Research
   Council [2016-01296]; Danish Karen Elise Jensen Foundation; Vinnova
   [2016-01296] Funding Source: Vinnova; Swedish Research Council
   [2016-01296] Funding Source: Swedish Research Council
FX This study was supported by the Danish Childhood Cancer Foundation
   (2015-15 and 2016-0261), the Rigshospitalet Research Foundation, the
   Danish Cancer Society (R165-A10527), the Danish Cancer Research
   Foundation, the Dagmar Marshall Foundation, the Hartmann Brothers
   Foundation (A30640), the Finnish Cancer Society, the Finnish Foundation
   of Pediatric Research, the Helsinki University Research Foundation, the
   Swedish Childhood Cancer Foundation (PR2017-0037 and TJ2015-0046), and
   the Swedish Research Council (2016-01296). K.M.P. and B.G.N. were
   supported by the Danish Karen Elise Jensen Foundation.
CR [Anonymous], 2019, R LANG ENV STAT COMP
   Asghar A, 2017, CELL IMMUNOL, V315, P18, DOI 10.1016/j.cellimm.2017.03.001
   Bajwa R, 2012, PEDIATR TRANSPLANT, V16, P872, DOI 10.1111/petr.12002
   Baker KS, 2012, BONE MARROW TRANSPL, V47, P619, DOI 10.1038/bmt.2011.118
   Baker KS, 2007, BLOOD, V109, P1765, DOI 10.1182/blood-2006-05-022335
   Bielorai B, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-0998-0
   Bielorai B, 2017, CLIN TRANSPLANT, V31, DOI 10.1111/ctr.12903
   Bio-Rad, BIO PLEX PROTM HUM C
   de Vathaire F, 2012, LANCET ONCOL, V13, P1002, DOI 10.1016/S1470-2045(12)70323-6
   Ebrahimi F, 2016, SWISS MED WKLY, V146, DOI 10.4414/smw.2016.14283
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Han TS, 2017, CURR OPIN SUPPORT PA, V11, P205, DOI 10.1097/SPC.0000000000000289
   Jagasia MH, 2015, BIOL BLOOD MARROW TR, V21, P389, DOI 10.1016/j.bbmt.2014.12.001
   Ketterl TG, 2018, BIOL BLOOD MARROW TR, V24, P622, DOI 10.1016/j.bbmt.2017.11.024
   Majhail NS, 2009, BONE MARROW TRANSPL, V43, P49, DOI 10.1038/bmt.2008.263
   Marott SCW, 2016, J CLIN ENDOCR METAB, V101, P3212, DOI 10.1210/jc.2015-3777
   Mathiesen S, 2020, BIOL BLOOD MARROW TR, V26, P1635, DOI 10.1016/j.bbmt.2020.05.009
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   Nielsen MM, 2021, BONE MARROW TRANSPL, V56, P457, DOI 10.1038/s41409-020-01038-3
   Mercer JR, 2010, CIRC RES, V107, P1021, DOI 10.1161/CIRCRESAHA.110.218966
   Miano M, 2007, BONE MARROW TRANSPL, V39, P89, DOI 10.1038/sj.bmt.1705550
   Neville KA, 2006, J CLIN ENDOCR METAB, V91, P4401, DOI 10.1210/jc.2006-0128
   Oudin C, 2015, BONE MARROW TRANSPL, V50, P1438, DOI 10.1038/bmt.2015.167
   Oudin C, 2011, BLOOD, V117, P4442, DOI 10.1182/blood-2010-09-304899
   Paris C, 2012, PEDIATR BLOOD CANCER, V59, P306, DOI 10.1002/pbc.24104
   Ragbourne SC, 2017, CL LYMPH MYELOM LEUK, V17, P340, DOI 10.1016/j.clml.2017.05.004
   Shalitin S, 2018, HORM RES PAEDIAT, V89, P108, DOI 10.1159/000486034
   Soeborg T, 2017, CLIN CHIM ACTA, V468, P180, DOI 10.1016/j.cca.2017.03.002
   Taskinen M, 2000, LANCET, V356, P993, DOI 10.1016/S0140-6736(00)02717-3
   Turcotte LM, 2016, BIOL BLOOD MARROW TR, V22, P1159, DOI 10.1016/j.bbmt.2016.03.016
   Wei C, 2015, PEDIATR BLOOD CANCER, V62, P1992, DOI 10.1002/pbc.25601
   WHO Consultation on Obesity, 2000, Obesity: preventing and managing the global epidemic. Report of a who consultation, V894
NR 32
TC 12
Z9 12
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2666-6375
EI 2666-6367
J9 TRANSPL CELL THER
JI Transpl. Cell. Ther.
PD SEP
PY 2021
VL 27
IS 9
DI 10.1016/j.jtct.2021.05.025
EA AUG 2021
PG 8
WC Hematology; Immunology; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Immunology; Transplantation
GA UI0WS
UT WOS:000690339400020
PM 34091072
OA hybrid
DA 2025-06-11
ER

PT J
AU Cayli, S
   Alimogullari, E
   Piskin, I
   Bilginoglu, A
   Nakkas, H
AF Cayli, Sevil
   Alimogullari, Ebru
   Piskin, Ilkay
   Bilginoglu, Ayca
   Nakkas, Hilal
TI Effect of pioglitazone on the expression of ubiquitin proteasome system
   and autophagic proteins in rat pancreas with metabolic syndrome
SO JOURNAL OF MOLECULAR HISTOLOGY
LA English
DT Article
DE p97; VCP; SVIP; Autophagy; Metabolic syndrome; Pancreas; Rat
ID INDUCED OXIDATIVE STRESS; BETA-CELL APOPTOSIS; PPAR-GAMMA;
   ENDOPLASMIC-RETICULUM; INSULIN SENSITIVITY; DB/DB MICE; GLUCOSE;
   GLUCOKINASE; PREVENTS; THERAPY
AB The metabolic syndrome (MetS) and pathologies associated with metabolic dysregulations a worldwide growing problem. Our previous study demonstrated that pioglitazone (PGZ) has beneficial effects on metabolic syndrome associated disturbances in the heart. However, mechanism mediating the molecular alterations of Ubiquitin proteasome system (UPS) and autophagy has not been investigated in rat pancreas with metabolic syndrome. For this reason, we first aimed to detect whether MetS effects on the expression of UPS (p97/VCP, SVIP, Ubiquitin) and autophagic (p62, LC3) proteins in rat pancreas. The second aim of the study was to find impact of pioglitazone on the expression of UPS and autophagic proteins in MetS rat pancreas. To answer these questions, metabolic syndrome induced rats were used as a model and treated with pioglitazone for 2 weeks. Pancreatic tissue injuries, fibrosis and lipid accumulation were evaluated histopathologically in control, MetS and MetS-PGZ groups. Apoptosis and cell proliferation of pancreatic islet cells were assessed in all groups. UPS and autophagic protein expressions of pancreas in all groups were detected by using immunohistochemistry, double-immunfluorescence and Western blotting. Compared with the controls, the rat fed with high sucrose exhibited signs of metabolic syndrome, such as higher body weight, insulin resistance, higher triglyceride level and hyperglycaemia. MetS rats showed pancreatic tissue degeneration, fibrosis and lipid accumulation when their pancreas were examined with Hematoxilen-eozin and Mallory trichrome staining. Metabolic, histopathologic parameters and cell proliferation showed greater improvement in MetS-PGZ rats and pioglitazone decreased apoptosis of islet cells. Moreover, SVIP, ubiquitin, LC3 and p62 expressions were significantly increased while only p97/VCP expression was significantly decreased in MetS-rat pancreas compared to control. PGZ treatment significantly decreased the MetS-induced increases in autophagy markers. Additionally, UPS and autophagy markers were found to colocalizated with insulin and glucagon. Colocalization ratio of UPS markers with insulin showed significant decrease in MetS rats and PGZ increased this ratio, whereas LC3-insulin colocalization displayed significant increase in MetS rats and PGZ reversed this effect. In conclusion, PGZ improved the pancreatic tissue degeneration by increasing the level of p97/VCP and decreasing autophagic proteins, SVIP and ubiquitin expressions in MetS-rats. Moreover, PGZ has an effect on the colocalization ratio of UPS and autophagy markers with insulin.
C1 [Cayli, Sevil; Alimogullari, Ebru; Piskin, Ilkay; Nakkas, Hilal] Ankara Yildirim Beyazit Univ, Fac Med, Dept Histol & Embryol, TR-06800 Ankara, Turkey.
   [Bilginoglu, Ayca] Ankara Yildirim Beyazit Univ, Fac Med, Dept Biophys, Ankara, Turkey.
C3 Ankara Yildirim Beyazit University; Ankara Yildirim Beyazit University
RP Cayli, S (corresponding author), Ankara Yildirim Beyazit Univ, Fac Med, Dept Histol & Embryol, TR-06800 Ankara, Turkey.
EM sevilcayli@yahoo.com
RI Cayli, Sevil/V-2342-2019; Piskin, Ilkay/LBH-6303-2024; Bilginoglu Topcu,
   Ayca/J-8076-2018; NAKKAŞ, HİLAL/AGF-6945-2022
OI BILGINOGLU, AYCA/0000-0002-1657-2607; Corumluoglu Piskin,
   Ilkay/0000-0002-5125-302X; NAKKAS, HILAL/0000-0003-0901-8875; Cayli,
   Sevil/0000-0003-2465-5389
FU Turkish Research Council (TUBITAK) [115S827]
FX This study was partially supported by Turkish Research Council (TUBITAK)
   with project number: 115S827.
CR Abella V, 2014, J IMMUNOL RES, V2014, DOI 10.1155/2014/343746
   Akcan G, 2020, REPROD BIOL, V20, P88, DOI 10.1016/j.repbio.2020.01.006
   Alba M, 2013, DIABETES OBES METAB, V15, P1101, DOI 10.1111/dom.12145
   Ballar P, 2007, J BIOL CHEM, V282, P33908, DOI 10.1074/jbc.M704446200
   Ballar P, 2011, INT J BIOCHEM CELL B, V43, P613, DOI 10.1016/j.biocel.2010.12.021
   Bilginoglu A, 2018, J BIOENERG BIOMEMBR, V50, P437, DOI 10.1007/s10863-018-9776-6
   Butler AE, 2003, DIABETES, V52, P2304, DOI 10.2337/diabetes.52.9.2304
   Catanzaro R, 2016, WORLD J GASTROENTERO, V22, P7660, DOI 10.3748/wjg.v22.i34.7660
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Galluzzi L, 2014, CELL, V159, P1263, DOI 10.1016/j.cell.2014.11.006
   Hartley T, 2009, AM J PHYSIOL-ENDOC M, V296, pE1, DOI 10.1152/ajpendo.90538.2008
   Höhn A, 2016, ANTIOXID REDOX SIGN, V25, P902, DOI 10.1089/ars.2016.6815
   Hofmeister-Brix A, 2013, BIOCHEM J, V456, P173, DOI 10.1042/BJ20130262
   Iizuka Y, 2016, PROSTAG LEUKOTR ESS, V115, P53, DOI 10.1016/j.plefa.2016.10.007
   Ishida H, 2004, METABOLISM, V53, P488, DOI 10.1016/j.metabol.2003.11.021
   Kahn SE, 2011, DIABETES, V60, P1552, DOI 10.2337/db10-1392
   Kanda Y, 2010, AM J PHYSIOL-ENDOC M, V298, pE278, DOI 10.1152/ajpendo.00388.2009
   Kaniuk NA, 2007, DIABETES, V56, P930, DOI 10.2337/db06-1160
   Kaufman RJ, 2010, DIABETES OBES METAB, V12, P99, DOI 10.1111/j.1463-1326.2010.01281.x
   Kim J, 2018, MOL CELLS, V41, P11, DOI 10.14348/molcells.2018.2228
   Kim KH, 2014, NAT REV ENDOCRINOL, V10, P322, DOI 10.1038/nrendo.2014.35
   Kim WH, 2005, DIABETES, V54, P2602, DOI 10.2337/diabetes.54.9.2602
   Kimura T, 2015, MOL CELL ENDOCRINOL, V400, P78, DOI 10.1016/j.mce.2014.11.018
   Kirk-Ballard H, 2014, NUTRITION, V30, pS21, DOI 10.1016/j.nut.2014.02.027
   Kobayashi T, 2007, GENES CELLS, V12, P889, DOI 10.1111/j.1365-2443.2007.01099.x
   Kwon MJ, 2019, DIABETES RES CLIN PR, V151, P209, DOI 10.1016/j.diabres.2019.04.006
   Lim H, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-03939-w
   Luciani DS, 2013, DIABETES, V62, P170, DOI 10.2337/db11-1464
   Matsui J, 2004, DIABETES, V53, P2844, DOI 10.2337/diabetes.53.11.2844
   Menikdiwela KR, 2020, CELL DEATH DIS, V11, DOI 10.1038/s41419-020-2275-9
   Nandi D, 2006, J BIOSCIENCES, V31, P137, DOI 10.1007/BF02705243
   Ozsoy AZ, 2018, PLACENTA, V67, P45, DOI 10.1016/j.placenta.2018.05.013
   Saitoh Y, 2008, DIABETES OBES METAB, V10, P564, DOI 10.1111/j.1463-1326.2007.00749.x
   Sidiropoulos PI, 2008, ARTHRITIS RES THER, V10, DOI 10.1186/ar2397
   Srinivasan D, 2015, EUR J PHARMACOL, V764, P38, DOI 10.1016/j.ejphar.2015.06.042
   Tomita T, 2016, BOSNIAN J BASIC MED, V16, P162, DOI 10.17305/bjbms.2016.919
   van den Boom J, 2018, MOL CELL, V69, P182, DOI 10.1016/j.molcel.2017.10.028
   van Raalte DH, 2014, EUR J ENDOCRINOL, V170, P565, DOI 10.1530/EJE-13-0639
   Villacorta L, 2009, CLIN SCI, V116, P205, DOI 10.1042/CS20080195
   Wang AP, 2013, ACTA DIABETOL, V50, P163, DOI 10.1007/s00592-010-0239-8
   Wang Y, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024478
   Yki-Jarvinen H, 2004, NEW ENGL J MED, V351, P1106, DOI 10.1056/NEJMra041001
   Zeender E, 2004, J CLIN ENDOCR METAB, V89, P5059, DOI 10.1210/jc.2004-0446
   Zhou X, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0115148
NR 44
TC 3
Z9 3
U1 1
U2 6
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1567-2379
EI 1567-2387
J9 J MOL HISTOL
JI J. Mol. Histol.
PD OCT
PY 2021
VL 52
IS 5
BP 929
EP 942
DI 10.1007/s10735-021-10013-1
EA AUG 2021
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA WA6XI
UT WOS:000686498100001
PM 34410563
DA 2025-06-11
ER

PT J
AU Godin, O
   Bennabi, D
   Yrondi, A
   Richieri, R
   D'Amato, T
   Bellivier, F
   Bougerol, T
   Horn, M
   Camus, V
   Courtet, P
   Doumy, O
   Genty, JB
   El-Hage, W
   Haesebaert, F
   Holtzmann, J
   Lancon, C
   Leboyer, M
   Llorca, PM
   Maruani, J
   Molière, F
   Samalin, L
   Schmitt, L
   Stephan, F
   Vaiva, G
   Walter, M
   Aouizerate, B
   Haffen, E
AF Godin, Ophelia
   Bennabi, Djamila
   Yrondi, Antoine
   Richieri, Raphaelle
   D'Amato, Thierry
   Bellivier, Franck
   Bougerol, Thierry
   Horn, Mathilde
   Camus, Vincent
   Courtet, Philippe
   Doumy, Olivier
   Genty, Jean Baptiste
   El-Hage, Wissam
   Haesebaert, Frederic
   Holtzmann, Jerome
   Lancon, Christophe
   Leboyer, Marion
   Llorca, Pierre Michel
   Maruani, Julia
   Moliere, Fanny
   Samalin, Ludovic
   Schmitt, Laurent
   Stephan, Florian
   Vaiva, Guillaume
   Walter, Michel
   Aouizerate, Bruno
   Haffen, Emmanuel
CA FondaMental Adv Ctr Expertise Resi
TI Prevalence of Metabolic Syndrome and Associated Factors in a Cohort of
   Individuals With Treatment-Resistant Depression: Results From the
   FACE-DR Study
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID STAR-ASTERISK-D; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; BIPOLAR
   DISORDER; RISK-FACTORS; SCHIZOPHRENIA; METAANALYSIS; COMPONENTS;
   OBESITY; DYSREGULATION
AB Background: The aim of this study was to estimate the prevalence of metabolic syndrome (MetS) and its components in a cohort of French patients with treatment-resistant depression (TRD) and to determine correlations with sociodemographic, clinical, and treatment-related factors.
   Methods: From 2012 to 2018, 205 patients who met DSM-IV criteria for major depressive episode with moderate-to-severe symptoms (Montgomery-Asberg Depression Rating Scale score >= 20), and at least Stage II resistance according to Thase and Rush criteria were enrolled in the FondaMental Advanced Centers of Expertise in Resistant Depression (FACE-DR) cohort. Data on sociodemographic and clinical characteristics, lifestyle information, and treatment and comorbidities were collected, and a blood sample was drawn. MetS was defined according to the criteria of the International Diabetes Federation.
   Results: Overall, 38% of individuals with TRD met criteria for MetS. The frequency of MetS was significantly higher in men than in women only for patients aged 40 years or older (463% vs 35.2%, P=.0427). Moreover, whereas the management for diabetes was good, less than one-third of the patients with high blood pressure or dyslipidemia were treated for these conditions. Multivariate analysis showed that individuals with abnormal plasma c-reactive protein levels had a 3-fold increased risk (95% CI, 1.5-5.2) of having MetS, independent of other potential confounders.
   Conclusion: The prevalence of MetS is higher in patients with TRD than in those with other psychiatric disorders and characterized by a considerable undertreatment of some components of MetS in this population. Diagnosis and treatment of the components of MetS should be systematically performed to prevent the occurrence of cardiovascular diseases in patients with TRD. These findings highlight the need for integrated care, with more interaction and coordination between psychiatrists and primary care providers.
C1 [Godin, Ophelia; Bennabi, Djamila; Yrondi, Antoine; Richieri, Raphaelle; D'Amato, Thierry; Bellivier, Franck; Bougerol, Thierry; Horn, Mathilde; Camus, Vincent; Courtet, Philippe; Doumy, Olivier; Genty, Jean Baptiste; El-Hage, Wissam; Haesebaert, Frederic; Holtzmann, Jerome; Lancon, Christophe; Leboyer, Marion; Llorca, Pierre Michel; Maruani, Julia; Moliere, Fanny; Samalin, Ludovic; Schmitt, Laurent; Stephan, Florian; Vaiva, Guillaume; Walter, Michel; Aouizerate, Bruno; Haffen, Emmanuel] FondaMental Fondat, Creteil, France.
   [Godin, Ophelia] Sorbonne Univ, IPLESP, INSERM, Paris, France.
   [Bennabi, Djamila; Haffen, Emmanuel] Bourgogne Franche Comte Univ, Treatment Resistant Depress Fondamental Expert Ct, Clin Psychiat Dept, EA Neurosci 481, Besancon, France.
   [Yrondi, Antoine; Schmitt, Laurent] CHRU Toulouse, Fondamental Expert Ctr Treatment Resistant Depres, Psychiat & Med Psychol Dept, Purpan Hosp, Toulouse, France.
   [Richieri, Raphaelle; Lancon, Christophe] CHU La Conception, Psychiat Dept, Fondamental Expert Ctr Treatment Resistant Depres, Marseille, France.
   [D'Amato, Thierry; Haesebaert, Frederic] Le Vinatier Hosp, Univ Hosp Dept Adult Psychiat, Fondamental Expert Ctr Treatment Resistant Depres, Bron, France.
   [Bellivier, Franck; Maruani, Julia] Univ Paris Diderot, GH St Louis Lariboisiere Fernand Widal, AP HP, INSERM,UMRS 1144, Paris, France.
   [Bougerol, Thierry; El-Hage, Wissam; Holtzmann, Jerome] Univ Joseph Fourier Grenoble I, BP 53, Grenoble, France.
   [Bougerol, Thierry; Holtzmann, Jerome; Moliere, Fanny] CHU Grenoble, Grenoble, France.
   [Bougerol, Thierry; Holtzmann, Jerome] GIN, Inserm U836, Chemin Fortune Ferrini, La Tronche, France.
   [Horn, Mathilde; Vaiva, Guillaume] Lille Univ, Fontan Hosp, Fondamental Expert Ctr Treatment Resistant Depres, Dept Adult Psychiat,CHU Lille,CNRS,UMR 9193, Lille, France.
   [Camus, Vincent; Doumy, Olivier] Tours Univ, Univ Psychiat Clin, Fondamental Expert Ctr Treatment Resistant Depres, CHRU Tours,Inserm U1253 Imaging & Brain iBrain, Tours, France.
   [Courtet, Philippe] Montpellier Univ, Dept Emergency Psychiat & Acute Care, INSERM U1061, CHU Montpellier, Montpellier, France.
   [Aouizerate, Bruno] Bordeaux Univ, Univ Dept Psychiat, Fondamental Expert Ctr Treatment Resistant Depres, CH Charles Perrens,NutriNeuro UMR INRA 1286, Bordeaux, France.
   [Genty, Jean Baptiste; Leboyer, Marion] Paris Est Univ, UPEC, UMR S955, Creteil, France.
   [Genty, Jean Baptiste; Leboyer, Marion] INSERM, U955 Team 15, Creteil, France.
   [Genty, Jean Baptiste; Leboyer, Marion] H Mondor A Chenevier Hosp, AP HP, Psychiat Dept, Creteil, France.
   [Llorca, Pierre Michel; Samalin, Ludovic; Stephan, Florian] Clermont Ferrand Univ, Fondamental Expert Ctr Treatment Resistant Depres, EA7280, CHU Clermont Ferrand, Clermont Ferrand, France.
   [Walter, Michel] CHRU Brest, Bohars Hosp, Dept Gen Psychiat & Psychosocial Rehabil 29G01 &, Fondamental Expert Ctr Treatment Resistant Depres, Bohars, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Sorbonne Universite; Universite de Franche-Comte; CHU de Toulouse;
   Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille;
   Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP);
   Hopital Universitaire Lariboisiere-Fernand-Widal - APHP; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Hopital
   Universitaire Saint-Louis - APHP; Communaute Universite Grenoble Alpes;
   Universite Grenoble Alpes (UGA); Communaute Universite Grenoble Alpes;
   Universite Grenoble Alpes (UGA); CHU Grenoble Alpes; CEA; Centre
   National de la Recherche Scientifique (CNRS); Institut National de la
   Sante et de la Recherche Medicale (Inserm); Universite de Lille; CHU
   Lille; Centre National de la Recherche Scientifique (CNRS); CNRS -
   Institute for Humanities & Social Sciences (INSHS); CHU Tours; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite de
   Montpellier; CHU de Montpellier; Universite de Bordeaux; INRAE;
   Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Institut National de
   la Sante et de la Recherche Medicale (Inserm); Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Assistance Publique Hopitaux
   Paris (APHP); Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Hopital
   Universitaire Henri-Mondor - APHP; Universite Clermont Auvergne (UCA);
   CHU Clermont Ferrand; CHU Brest
RP Godin, O (corresponding author), Hop La Pitie Salpetriere, Inst Pierre Louis Epidemiol & Sante Publ, UMR S 1136, F-75651 Paris 13, France.
EM ophelia.godin@upmc.fr
RI Fond, Guillaume/D-7646-2011; richieri, raphaelle/E-4707-2015; haffen,
   emmanuel/R-2765-2017; EL-HAGE, WISSAM/S-5014-2019; Leboyer,
   Marion/AAW-3648-2021; Samalin, Ludovic/AAP-6362-2020; djamila,
   bennabi/AAI-7456-2020; Camus, Vincent/ABC-4021-2020; Haesebaert,
   Frederic/D-9264-2018; VAIVA, Guillaume/J-8983-2015
OI RICHIERI, Raphaelle/0000-0002-3901-7016; Haesebaert,
   Frederic/0000-0002-6813-9012; Aouizerate, Bruno/0000-0002-7092-7747;
   Samalin, Ludovic/0000-0003-0740-4019; Bennabi,
   Djamila/0000-0001-5080-2501; VAIVA, Guillaume/0000-0003-2462-008X;
   EL-HAGE, WISSAM/0000-0003-3877-0855; Yrondi,
   Antoine/0000-0002-2650-6080; Horn, Mathilde/0000-0001-8968-9454; Cazals,
   Aurelie/0000-0002-4907-8568
FU Fondation FondaMental; Institut National de la Sante et de la Recherche
   Medicale (INSERM); AP-HP (Assistance Publique des Hopitaux de Paris);
   Astra Zeneca; Investissements d'Avenir program [ANR-11-IDEX-0004-02]
FX This research was supported by the Fondation FondaMental, Institut
   National de la Sante et de la Recherche Medicale (INSERM), AP-HP
   (Assistance Publique des Hopitaux de Paris), Astra Zeneca, and the
   Investissements d'Avenir program managed by the ANR under reference
   ANR-11-IDEX-0004-02.
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Balestri M, 2016, J AFFECT DISORDERS, V189, P224, DOI 10.1016/j.jad.2015.09.033
   Balkau B, 2003, DIABETES METAB, V29, P526, DOI 10.1016/S1262-3636(07)70067-8
   Barefoot JC, 1996, CIRCULATION, V93, P1976, DOI 10.1161/01.CIR.93.11.1976
   Bennabi D, 2015, J AFFECT DISORDERS, V171, P137, DOI 10.1016/j.jad.2014.09.020
   Correll CU, 2015, WORLD PSYCHIATRY, V14, P119, DOI 10.1002/wps.20204
   De Hert M, 2018, DIALOGUES CLIN NEURO, V20, P31, DOI 10.31887/DCNS.2018.20.1/mdehert
   Hert M, 2012, NAT REV ENDOCRINOL, V8, P114, DOI 10.1038/nrendo.2011.156
   Fava M, 2003, BIOL PSYCHIAT, V53, P649, DOI 10.1016/S0006-3223(03)00231-2
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   FRASURESMITH N, 1993, JAMA-J AM MED ASSOC, V270, P1819, DOI 10.1001/jama.270.15.1819
   Gilmer WS, 2005, ACTA PSYCHIAT SCAND, V112, P425, DOI 10.1111/j.1600-0447.2005.00633.x
   Godin O, 2015, SCHIZOPHR RES, V168, P388, DOI 10.1016/j.schres.2015.07.047
   Godin O, 2014, J CLIN PSYCHIAT, V75, P1078, DOI 10.4088/JCP.14m09038
   Haroon E, 2018, PSYCHONEUROENDOCRINO, V95, P43, DOI 10.1016/j.psyneuen.2018.05.026
   Hiles SA, 2016, DEPRESS ANXIETY, V33, P754, DOI 10.1002/da.22512
   Ijaz S, 2018, BMC PSYCHIATRY, V18, DOI 10.1186/s12888-018-1848-y
   Iosifescu Dan V, 2004, Curr Psychiatry Rep, V6, P193, DOI 10.1007/s11920-004-0064-2
   Lamers F, 2013, MOL PSYCHIATR, V18, P692, DOI 10.1038/mp.2012.144
   Lasserre AM, 2014, JAMA PSYCHIAT, V71, P880, DOI 10.1001/jamapsychiatry.2014.411
   Marijnissen RM, 2017, PSYCHOL MED, V47, P1041, DOI 10.1017/S0033291716003196
   Marijnissen RM, 2013, J AFFECT DISORDERS, V151, P1138, DOI 10.1016/j.jad.2013.07.029
   Misdrahi D, 2004, ENCEPHALE, V30, P409
   MONTGOMERY SA, 1979, BRIT J PSYCHIAT, V134, P382, DOI 10.1192/bjp.134.4.382
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Murphy JA, 2012, J AFFECT DISORDERS, V139, P172, DOI 10.1016/j.jad.2012.01.033
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pannier B, 2006, DIABETES METAB, V32, P467, DOI 10.1016/S1262-3636(07)70305-1
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Penninx BWJH, 2017, NEUROSCI BIOBEHAV R, V74, P277, DOI 10.1016/j.neubiorev.2016.07.003
   Penninx BWJH, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-129
   Rosa Adriane R, 2007, Clin Pract Epidemiol Ment Health, V3, P5, DOI 10.1186/1745-0179-3-5
   Rummel-Kluge C, 2010, SCHIZOPHR RES, V123, P225, DOI 10.1016/j.schres.2010.07.012
   Rush AJ, 2006, AM J PSYCHIAT, V163, P1905, DOI 10.1176/appi.ajp.163.11.1905
   Sagud M, 2013, PSYCHOPHARMACOLOGY, V230, P15, DOI 10.1007/s00213-013-3085-x
   Sarwar N, 2010, LANCET, V375, P2215, DOI 10.1016/s0140-6736(10)60484-9
   Sheehan DV, 1998, J CLIN PSYCHIAT, V59, P22, DOI 10.4088/JCP.09m05305whi
   Souery D, 2007, J CLIN PSYCHIAT, V68, P1062, DOI 10.4088/JCP.v68n0713
   Spielberger C. D., 1983, Manual for the State-Trait-Anxiety Inventory: STAI (form Y)
   Thase ME, 1997, J CLIN PSYCHIAT, V58, P23
   Trivedi MH, 2004, PSYCHOL MED, V34, P73, DOI 10.1017/S0033291703001107
   Trivedi MH, 2006, AM J PSYCHIAT, V163, P28, DOI 10.1176/appi.ajp.163.1.28
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vogelzangs N, 2014, NEUROPSYCHOPHARMACOL, V39, P1624, DOI 10.1038/npp.2014.9
   Woo YS, 2016, J AFFECT DISORDERS, V203, P190, DOI 10.1016/j.jad.2016.06.018
   Yrondi A, 2017, FRONT PSYCHIATRY, V8, DOI 10.3389/fpsyt.2017.00244
NR 48
TC 20
Z9 21
U1 0
U2 5
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD NOV-DEC
PY 2019
VL 80
IS 6
AR 19m12755
DI 10.4088/JCP.19m12755
PG 9
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA KR7NW
UT WOS:000517803900009
PM 31617968
DA 2025-06-11
ER

PT J
AU Pinto, BAS
   Melo, TM
   Flister, KFT
   França, LM
   Moreira, VR
   Kajihara, D
   Mendes, NO
   Pereira, SR
   Laurindo, FRM
   Paes, AMA
AF Serra Pinto, Bruno Araujo
   Melo, Thamys Marinho
   Torres Flister, Karla Frida
   Franca, Lucas Martins
   Moreira, Vanessa Ribeiro
   Kajihara, Daniela
   Mendes, Nelmar Oliveira
   Pereira, Silma Regina
   Martins Laurindo, Francisco Rafael
   Andrade Paes, Antonio Marcus
TI Hippocampal Endoplasmic Reticulum Stress Hastens Motor and Cognitive
   Decline in Adult Male Rats Sustainedly Exposed to High-Sucrose Diet
SO ANTIOXIDANTS
LA English
DT Article
DE high-sucrose diet; metabolic syndrome; hippocampus; ER stress; cognitive
   and motor impairments
ID UNFOLDED PROTEIN RESPONSE; INDUCED INSULIN-RESISTANCE; FRUCTOSE CORN
   SYRUP; OXIDATIVE STRESS; INDUCED OBESITY; ER STRESS; SPATIAL MEMORY;
   BRAIN; CONSUMPTION; GLUCOSE
AB Metabolic dysfunctions, such as hyperglycemia and insulin resistance, have been associated to cognitive impairment and dementia regardless of advanced age, although the underlying mechanisms are still elusive. Thus, this study investigates the deleterious effects of metabolic syndrome (MetS) induced by long-term exposure to a high-sucrose diet on motor and cognitive functions of male adult rats and its relationship with hippocampal endoplasmic reticulum (ER) stress. Weaned Wistar male rats were fed a high-sucrose diet until adulthood (HSD; 6 months old) and compared to both age-matched (CTR; 6 months old) and middle-aged chow-fed rats (OLD; 20 months old). MetS development, serum redox profile, behavioral, motor, and cognitive functions, and hippocampal gene/protein expressions for ER stress pro-adaptive and pro-apoptotic pathways, as well as senescence markers were assessed. Prolonged exposure to HSD induced MetS hallmarked by body weight gain associated to central obesity, hypertriglyceridemia, insulin resistance, and oxidative stress. Furthermore, HSD rats showed motor and cognitive decline similar to that in OLD animals. Noteworthy, HSD rats presented marked hippocampal ER stress characterized by failure of pro-adaptive signaling and increased expression of Chop, p21, and Parp-1 cleavage, markers of cell death and aging. This panorama resembles that found in OLD rats. In toto, our data showed that early and sustained exposure to a high-sucrose diet induced MetS, which subsequently led to hippocampus homeostasis disruption and premature impairment of motor and cognitive functions in adult rats.
C1 [Serra Pinto, Bruno Araujo; Melo, Thamys Marinho; Torres Flister, Karla Frida; Franca, Lucas Martins; Mendes, Nelmar Oliveira; Andrade Paes, Antonio Marcus] Univ Fed Maranhao, Dept Physiol Sci, Lab Expt Physiol, Av Portugueses 1966, BR-65080805 Sao Luis, Maranhao, Brazil.
   [Moreira, Vanessa Ribeiro; Pereira, Silma Regina] Univ Fed Maranhao, Dept Biol, Lab Genet & Mol Biol, Av Portugueses 1966, BR-65080805 Sao Luis, Maranhao, Brazil.
   [Kajihara, Daniela; Martins Laurindo, Francisco Rafael] Univ Sao Paulo, Sch Med, Heart Inst, Lab Vasc Biol, Av Dr Eneas Carvalho Aguilar 44, BR-05403900 Sao Paulo, SP, Brazil.
C3 Universidade Federal do Maranhao; Universidade Federal do Maranhao;
   Universidade de Sao Paulo
RP Paes, AMA (corresponding author), Univ Fed Maranhao, Dept Physiol Sci, Lab Expt Physiol, Av Portugueses 1966, BR-65080805 Sao Luis, Maranhao, Brazil.
EM bruno.pinto@ufma.br; thamys.marinho@discente.ufma.br;
   karla.flister@ufma.br; lucas.mf@ufma.br; more_nessa@yahoo.com.br;
   d.kajihara@hc.fm.usp.br; nelmar.mendes@discente.ufma.br;
   silma.pereira@ufma.br; francisco.laurindo@incor.usp.br;
   marcuspaes@ufma.br
RI França, Lucas/IAM-5986-2023; Laurindo, Francisco/J-6575-2015; moreira,
   vanessa/GQO-7744-2022; Kajihara, Daniela/AAR-1172-2020; Paes, Antonio
   Marcus de Andrade/C-7174-2013
OI Paes, Antonio Marcus de Andrade/0000-0002-3803-9803; Kajihara,
   Daniela/0000-0001-9239-4198; Martins Franca, Lucas/0000-0002-4412-1539;
   ARAUJO SERRA PINTO, BRUNO/0000-0003-3595-0578; Laurindo,
   Francisco/0000-0001-6837-4509
FU Fundacao deAmparo a Pesquisa e aoDesenvolvimento Cientifico e
   Tecnologico doMaranhao-FAPEMA [FAPEMA PAEDT-00380/14, PAEDT-02085/15,
   ESTAGIO-05258/15, UNIVERSAL-00523/14, UNIVERSAL-00792/14]; Coordenacao
   de Aperfeicoamento de Pessoal de Nivel Superior-CAPES [001]; Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq
   [308163/2019-2]; FAPEMA [POS-GRAD-02598/21]
FX This researchwas funded by Fundacao deAmparo a Pesquisa e
   aoDesenvolvimento Cientifico e Tecnologico doMaranhao-FAPEMA, grant
   numbers FAPEMA PAEDT-00380/14, PAEDT-02085/15, ESTAGIO-05258/15,
   UNIVERSAL-00523/14, UNIVERSAL-00792/14; Coordenacao de Aperfeicoamento
   de Pessoal de Nivel Superior-CAPES, Finance Code 001 and fellowship to
   V.R.M.; and Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico-CNPq, fellowship to T.M.M. and A.M.A.P. (308163/2019-2). The
   APC was funded by FAPEMA, grant number POS-GRAD-02598/21.
CR Agrawal R, 2012, J PHYSIOL-LONDON, V590, P2485, DOI 10.1113/jphysiol.2012.230078
   Ahima RS, 2009, NAT MED, V15, P996, DOI 10.1038/nm0909-996
   Alasantro LH, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0249348
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Basciano Heather, 2005, Nutr Metab (Lond), V2, P5, DOI 10.1186/1743-7075-2-5
   Beilharz JE, 2016, BEHAV BRAIN RES, V306, P1, DOI 10.1016/j.bbr.2016.03.018
   Beilharz JE, 2016, BRAIN BEHAV IMMUN, V57, P304, DOI 10.1016/j.bbi.2016.07.151
   BERNARDIS LL, 1968, J ENDOCRINOL, V40, P527, DOI 10.1677/joe.0.0400527
   Birkenfeld AL, 2011, J BIOL CHEM, V286, P36163, DOI 10.1074/jbc.M111.228817
   Botezelli JD, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-78
   Bray GA, 2004, AM J CLIN NUTR, V79, P537
   Bray George A, 2010, J Diabetes Sci Technol, V4, P1003
   Brooks SP, 2009, NAT REV NEUROSCI, V10, P519, DOI 10.1038/nrn2652
   Brown MK, 2012, FRONT PHYSIOL, V3, DOI 10.3389/fphys.2012.00263
   Bruns DR, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/732596
   Cenquizca LA, 2007, BRAIN RES REV, V56, P1, DOI 10.1016/j.brainresrev.2007.05.002
   Chaitanya GV, 2010, CELL COMMUN SIGNAL, V8, DOI 10.1186/1478-811X-8-31
   Chen WM, 2009, MOL CELL, V34, P663, DOI 10.1016/j.molcel.2009.04.029
   Cullinan SB, 2004, J BIOL CHEM, V279, P20108, DOI 10.1074/jbc.M314219200
   Fakih W, 2022, OBESITY, V30, P982, DOI 10.1002/oby.23400
   Faul F, 2007, BEHAV RES METHODS, V39, P175, DOI 10.3758/BF03193146
   Finkel T, 2000, NATURE, V408, P239, DOI 10.1038/35041687
   Fonseca ACRG, 2013, BBA-MOL BASIS DIS, V1832, P2191, DOI 10.1016/j.bbadis.2013.08.007
   Franca LM, 2014, BIOCHEM BIOPH RES CO, V443, P725, DOI 10.1016/j.bbrc.2013.12.042
   Gavilán MP, 2006, NEUROBIOL AGING, V27, P973, DOI 10.1016/j.neurobiolaging.2005.05.010
   Ghosh A, 2017, ENDOCRINOLOGY, V158, P903, DOI 10.1210/en.2016-1576
   Gounder SS, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0045697
   Guerrero-Romero F, 2010, J CLIN ENDOCR METAB, V95, P3347, DOI 10.1210/jc.2010-0288
   Guillemot-Legris O, 2017, TRENDS NEUROSCI, V40, P237, DOI 10.1016/j.tins.2017.02.005
   Hafycz JM, 2022, AGING CELL, V21, DOI 10.1111/acel.13598
   Hall CS, 1932, Univ. Calif. Publ. Psychol., V6, P1
   Hayashi A, 2008, BIOCHEM BIOPH RES CO, V376, P758, DOI 10.1016/j.bbrc.2008.09.059
   Hayashi A, 2007, J BIOL CHEM, V282, P34525, DOI 10.1074/jbc.M704300200
   Hetz C, 2014, NAT REV NEUROSCI, V15, P233, DOI 10.1038/nrn3689
   Hetz C, 2012, NAT REV MOL CELL BIO, V13, P89, DOI 10.1038/nrm3270
   Hossain MM, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11121961
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Hsu TM, 2015, HIPPOCAMPUS, V25, P227, DOI 10.1002/hipo.22368
   Huang TT, 2015, ARCH BIOCHEM BIOPHYS, V576, P2, DOI 10.1016/j.abb.2015.03.014
   Huang X, 2013, OBESITY, V21, P85, DOI 10.1002/oby.20007
   Hussain SG, 2007, BIOCHEM BIOPH RES CO, V355, P365, DOI 10.1016/j.bbrc.2007.01.156
   Jurdak N, 2008, NUTR NEUROSCI, V11, P48, DOI 10.1179/147683008X301333
   KANAREK RB, 1982, J NUTR, V112, P1546, DOI 10.1093/jn/112.8.1546
   Kanazawa M, 2003, NUTR REV, V61, pS27, DOI 10.1301/nr.2003.may.S27-S33
   Kolderup A, 2015, J NUTR METAB, V2015, DOI 10.1155/2015/823081
   Lakhan SE, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-114
   Lee YS, 2008, MOL ENDOCRINOL, V22, P2176, DOI 10.1210/me.2008-0023
   Lemmer IL, 2021, MOL METAB, V47, DOI 10.1016/j.molmet.2021.101169
   Lemos C, 2016, NEUROSCIENCE, V315, P196, DOI 10.1016/j.neuroscience.2015.12.018
   Lomeli N, 2017, CLIN SCI, V131, P2573, DOI 10.1042/CS20160982
   Sousa RML, 2018, NUTR METAB, V15, DOI 10.1186/s12986-018-0290-y
   Malhotra JD, 2007, SEMIN CELL DEV BIOL, V18, P716, DOI 10.1016/j.semcdb.2007.09.003
   Maniam J, 2016, FRONT MOL NEUROSCI, V8, DOI 10.5589/fnmol.2015.00086
   Marcelino TB, 2013, NEUROSCIENCE, V246, P28, DOI 10.1016/j.neuroscience.2013.04.043
   Martínez G, 2016, CELL REP, V14, P1382, DOI 10.1016/j.celrep.2016.01.028
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McGinnis KM, 1999, BIOCHEM BIOPH RES CO, V263, P94, DOI 10.1006/bbrc.1999.1315
   Minamino T, 2009, NAT MED, V15, P1082, DOI 10.1038/nm.2014
   Mitchell CS, 2022, FRONT PHYSIOL, V13, DOI 10.3389/fphys.2022.841935
   MORRIS R, 1984, J NEUROSCI METH, V11, P47, DOI 10.1016/0165-0270(84)90007-4
   Moser MB, 1998, HIPPOCAMPUS, V8, P608, DOI 10.1002/(SICI)1098-1063(1998)8:6<608::AID-HIPO3>3.0.CO;2-7
   Naidoo N, 2008, J NEUROSCI, V28, P6539, DOI 10.1523/JNEUROSCI.5685-07.2008
   Newens KJ, 2016, J HUM NUTR DIET, V29, P225, DOI 10.1111/jhn.12338
   Pal K, 2018, SOC PSYCH PSYCH EPID, V53, P1149, DOI 10.1007/s00127-018-1581-3
   Parks EJ, 2008, J NUTR, V138, P1039, DOI 10.1093/jn/138.6.1039
   Rafacho A, 2007, CAN J PHYSIOL PHARM, V85, P536, DOI 10.1139/Y07-037
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   SASTRE J, 1989, LIFE SCI, V45, P183, DOI 10.1016/0024-3205(89)90293-2
   Pinto BAS, 2016, METAB BRAIN DIS, V31, P917, DOI 10.1007/s11011-016-9830-1
   Shen FY, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00332
   Sims-Robinson C, 2012, DIABETOLOGIA, V55, P2276, DOI 10.1007/s00125-012-2573-6
   Solon-Biet SM, 2014, CELL METAB, V19, P418, DOI 10.1016/j.cmet.2014.02.009
   Sorensen A, 2008, OBESITY, V16, P566, DOI 10.1038/oby.2007.58
   Srodulski S, 2014, MOL NEURODEGENER, V9, DOI 10.1186/1750-1326-9-30
   Stranahan AM, 2008, HIPPOCAMPUS, V18, P1085, DOI 10.1002/hipo.20470
   Strange BA, 2014, NAT REV NEUROSCI, V15, P655, DOI 10.1038/nrn3785
   Suh JH, 2004, P NATL ACAD SCI USA, V101, P3381, DOI 10.1073/pnas.0400282101
   Tappy L, 2010, PHYSIOL REV, V90, P23, DOI 10.1152/physrev.00019.2009
   Taylor RC, 2016, BRAIN RES, V1648, P588, DOI 10.1016/j.brainres.2016.04.017
   Wang SY, 2012, J CELL BIOL, V197, P857, DOI 10.1083/jcb.201110131
   Wiley CD, 2021, NAT METAB, V3, P1290, DOI 10.1038/s42255-021-00483-8
   Wong A, 2017, BEHAV BRAIN RES, V327, P144, DOI 10.1016/j.bbr.2017.03.029
   Zhang YQ, 2015, ARCH BIOCHEM BIOPHYS, V576, P39, DOI 10.1016/j.abb.2014.12.018
NR 84
TC 6
Z9 6
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUL
PY 2022
VL 11
IS 7
AR 1395
DI 10.3390/antiox11071395
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 3J8SD
UT WOS:000833659900001
PM 35883886
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Naderpoor, N
   Shorakae, S
   Joham, A
   Boyle, J
   De Courten, B
   Teede, HJ
AF Naderpoor, N.
   Shorakae, S.
   Joham, A.
   Boyle, J.
   De Courten, B.
   Teede, H. J.
TI Obesity and polycystic ovary syndrome
SO MINERVA ENDOCRINOLOGICA
LA English
DT Article
DE Obesity; Insulin resistance; Hyperandrogenism; Polycystic ovary syndrome
ID IMPAIRED GLUCOSE-TOLERANCE; BODY-MASS INDEX; TYPE-2 DIABETES-MELLITUS;
   NERVE GROWTH-FACTOR; INSULIN-RESISTANCE; WEIGHT-LOSS; METABOLIC
   SYNDROME; FAT DISTRIBUTION; LIFE-STYLE; PHYSICAL-ACTIVITY
AB Obesity is now a major international health concern. It is increasingly common in young women with reproductive, metabolic and psychological health impacts. Reproductive health impacts are often poorly appreciated and include polycystic ovary syndrome (PCOS), infertility and pregnancy complications. PCOS is the most common endocrine condition in women and is underpinned by hormonal disturbances including insulin resistance and hyperandrogenism. Obesity exacerbates hormonal and clinical features of PCOS and women with PCOS appear at higher risk of obesity, with multiple underlying mechanisms linking the conditions. Lifestyle intervention is first line in management of PCOS to both prevent weight gain and induce weight loss; however improved engagement and sustainability remain challenges with the need for more research. Medications like metformin, orlistat, GLP1 agonists and bariatric surgery have been used with the need for large scale randomised clinical trials to define their roles.
C1 [Naderpoor, N.; Shorakae, S.; Joham, A.; Boyle, J.; De Courten, B.; Teede, H. J.] Monash Univ, Sch Publ Hlth & Prevent Med, Monash Ctr Hlth Res & Implementat, MHRP, Clayton, Vic, Australia.
   [Teede, H. J.] Univ Adelaide, Robinson Res Inst, Discipline Obstet & Gynaecol, Adelaide, SA, Australia.
   [Naderpoor, N.; Shorakae, S.; Joham, A.; De Courten, B.; Teede, H. J.] Monash Hlth, Diabet & Vasc Med Unit, Clayton, Vic, Australia.
C3 Monash University; University of Adelaide; Robinson Research Institute;
   Monash Health
RP Teede, HJ (corresponding author), Monash Med Ctr, Locked Bag 29, Clayton, Vic 3168, Australia.
EM helena.teede@monash.edu
RI Joham, Anju/AAD-6020-2019; de Courten, Barbora/B-3308-2012; Boyle,
   Jacqueline/AAD-3246-2019; Naderpoor, Negar/IUM-7706-2023
OI Boyle, Jacqueline/0000-0002-3616-1637; Teede,
   Helena/0000-0001-7609-577X; Naderpoor, Negar/0000-0002-1738-3189
FU NHMRC
FX Prof Teede is an NHMRC Practitioner Fellow and Dr Joham and Dr Shorakae
   are NHMRC Scholarship holders.
CR Alvarez-Blasco F, 2006, ARCH INTERN MED, V166, P2081, DOI 10.1001/archinte.166.19.2081
   [Anonymous], 2003, ASIA PAC J CLIN NUTR
   Asemi Z, 2014, HORMON STOFFWECHSELF
   Asemi Z, 2014, NUTRITION, V30, P1287, DOI 10.1016/j.nut.2014.03.008
   Asunción M, 2000, J CLIN ENDOCR METAB, V85, P2434, DOI 10.1210/jc.85.7.2434
   Azziz R, 2004, J CLIN ENDOCR METAB, V89, P2745, DOI 10.1210/jc.2003-032046
   Bailey AP, 2014, AM J OBSTET GYNECOL, V211, DOI 10.1016/j.ajog.2014.03.035
   Motta AB, 2012, CURR PHARM DESIGN, V18, P2482, DOI 10.2174/13816128112092482
   Berger JJ, 2014, INT J WOMENS HEALTH, V6, P613, DOI 10.2147/IJWH.S48527
   Beydoun HA, 2009, REPROD BIOMED ONLINE, V18, P856, DOI 10.1016/S1472-6483(10)60037-5
   Brassard M, 2008, MED CLIN N AM, V92, P1163, DOI 10.1016/j.mcna.2008.04.008
   Brewer CJ, 2010, REPRODUCTION, V140, P347, DOI 10.1530/REP-09-0568
   Carmina E, 2003, HUM REPROD, V18, P2289, DOI 10.1093/humrep/deg440
   Carmina E, 2013, FRONT HORM RES, V40, P40, DOI 10.1159/000341840
   CLARK AM, 1995, HUM REPROD, V10, P2705, DOI 10.1093/oxfordjournals.humrep.a135772
   Colquitt J.L., 2009, COCHRANE DB SYST REV, pCD003641, DOI [DOI 10.1002/14651858.CD003641.PUB3, 10.1002/14651858.cd003641.pub3]
   Conway G, 2014, EUR J ENDOCRINOL, V171, pP1, DOI 10.1530/EJE-14-0253
   CONWAY GS, 1992, CLIN ENDOCRINOL, V37, P119, DOI 10.1111/j.1365-2265.1992.tb02295.x
   Coviello AD, 2006, J CLIN ENDOCR METAB, V91, P492, DOI 10.1210/jc.2005-1666
   Daemers DOA, 2014, BJOG-INT J OBSTET GY, V121, P1403, DOI 10.1111/1471-0528.12684
   Dampney RAL, 2011, J PHYSIOL-LONDON, V589, P2109, DOI 10.1113/jphysiol.2011.208579
   Diamanti-Kandarakis E, 1999, J CLIN ENDOCR METAB, V84, P4006, DOI 10.1210/jc.84.11.4006
   Diamanti-Kandarakis E, 2006, ANN NY ACAD SCI, V1092, P175, DOI 10.1196/annals.1365.015
   Diamanti-Kandarakis E, 2012, ENDOCR REV, V33, P981, DOI 10.1210/er.2011-1034
   Dietz WH, 2005, NEW ENGL J MED, V352, P2100, DOI 10.1056/NEJMcp043052
   Dissen GA, 2009, ENDOCRINOLOGY, V150, P2906, DOI 10.1210/en.2008-1575
   Duleba AJ, 2012, FERTIL STERIL, V97, P7, DOI 10.1016/j.fertnstert.2011.11.023
   Dunaif A., 1193, ANN NY ACAD SCI, V687, P60
   Ehrmann DA, 1999, DIABETES CARE, V22, P141, DOI 10.2337/diacare.22.1.141
   Farshchi H, 2007, J OBSTET GYNAECOL, V27, P762, DOI 10.1080/01443610701667338
   Fauser BCJM, 2012, FERTIL STERIL, V97, P28, DOI 10.1016/j.fertnstert.2011.09.024
   Fauser BCJM, 2004, HUM REPROD, V19, P41, DOI 10.1093/humrep/deh098
   Ford ES, 2014, JAMA-J AM MED ASSOC, V312, P1151, DOI 10.1001/jama.2014.8362
   Galtier-Dereure F, 2000, AM J CLIN NUTR, V71, p1242S, DOI 10.1093/ajcn/71.5.1242s
   Georgopoulos NA, 2009, FERTIL STERIL, V92, P250, DOI 10.1016/j.fertnstert.2008.04.067
   Ghandi S, 2011, J ASSIST REPROD GEN, V28, P591, DOI 10.1007/s10815-011-9564-2
   Ginter E, 2014, BRATISL MED J, V115, P527, DOI 10.4149/BLL_2014_102
   Gonzalez F, 1999, METABOLISM, V48, P437, DOI 10.1016/S0026-0495(99)90100-2
   Gower BA, 2013, CLIN ENDOCRINOL, V79, P550, DOI 10.1111/cen.12175
   GUZICK DS, 1994, FERTIL STERIL, V61, P598
   Haqq L, 2014, INT J SPORT NUTR EXE
   Haqq L, 2014, ENDOCR CONNECT, V3, P36, DOI 10.1530/EC-14-0010
   Harrison CL, 2011, HUM REPROD UPDATE, V17, P171, DOI 10.1093/humupd/dmq045
   Heider U, 2001, FERTIL STERIL, V75, P1141, DOI 10.1016/S0015-0282(01)01805-2
   Hirschberg AL, 2004, GYNECOL ENDOCRINOL, V19, P79, DOI 10.1080/09513590400002300
   Hollmann M, 1996, HUM REPROD, V11, P1884
   HOLTE J, 1994, CLIN ENDOCRINOL, V41, P463, DOI 10.1111/j.1365-2265.1994.tb02577.x
   HOLTE J, 1994, CLIN ENDOCRINOL, V41, P473, DOI 10.1111/j.1365-2265.1994.tb02578.x
   Hopkins DFC, 1997, DIABETIC MED, V14, P1044, DOI 10.1002/(SICI)1096-9136(199712)14:12<1044::AID-DIA508>3.0.CO;2-F
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Hu FB, 2003, J WOMEN HEALTH GEN-B, V12, P163, DOI 10.1089/154099903321576565
   Hu FB, 2001, NEW ENGL J MED, V345, P790, DOI 10.1056/NEJMoa010492
   Hutchison SK, 2011, J CLIN ENDOCR METAB, V96, pE48, DOI 10.1210/jc.2010-0828
   Jason J, 2011, ARCH INTERN MED, V171, P1209, DOI 10.1001/archinternmed.2011.288
   Jensterle M, 2015, ENDOCR RES, V40, P133, DOI 10.3109/07435800.2014.966385
   Johnson NP, 2014, ANN TRANSL MED, V2, DOI 10.3978/j.issn.2305-5839.2014.04.15
   Kalra P, 2009, FERTIL STERIL, V91, P1437, DOI 10.1016/j.fertnstert.2008.06.037
   Kann S, 2014, GLAND SURG, V3, P181, DOI 10.3978/j.issn.2227-684X.2013.12.01
   Kaya C, 2009, REPROD BIOMED ONLINE, V19, P721, DOI 10.1016/j.rbmo.2009.06.005
   KIDDY DS, 1990, CLIN ENDOCRINOL, V32, P213, DOI 10.1111/j.1365-2265.1990.tb00857.x
   Kral JG, 2012, OBESITY FACTS, V5, P254, DOI 10.1159/000338566
   Laitinen J, 2003, INT J OBESITY, V27, P710, DOI 10.1038/sj.ijo.0802301
   Lansdown A, 2012, CLIN ENDOCRINOL, V77, P791, DOI 10.1111/cen.12003
   Lara HE, 2000, ENDOCRINOLOGY, V141, P1059, DOI 10.1210/en.141.3.1059
   Legro RS, 1999, J CLIN ENDOCR METAB, V84, P165, DOI 10.1210/jc.84.1.165
   Legro RS, 2004, OBSTET GYNECOL SURV, V59, P141, DOI 10.1097/01.OGX.0000109523.25076.E2
   Lim SS, 2013, OBES REV, V14, P95, DOI 10.1111/j.1467-789X.2012.01053.x
   Lim SS, 2012, HUM REPROD UPDATE, V18, P618, DOI 10.1093/humupd/dms030
   Liou TH, 2009, FERTIL STERIL, V92, P1960, DOI 10.1016/j.fertnstert.2008.09.003
   Magnotti M, 2007, MED CLIN N AM, V91, P1151, DOI 10.1016/j.mcna.2007.06.010
   Maheshwari A, 2007, HUM REPROD UPDATE, V13, P433, DOI 10.1093/humupd/dmm017
   Mahoney D, 2014, J AM ASSOC NURSE PRA, V26, P301, DOI 10.1002/2327-6924.12073
   Malik SM, 2012, WORLD J DIABETES, V3, P71, DOI 10.4239/wjd.v3.i4.71
   March WA, 2010, HUM REPROD, V25, P544, DOI 10.1093/humrep/dep399
   Mason C, 2011, AM J PREV MED, V41, P366, DOI 10.1016/j.amepre.2011.06.042
   McDonagh MS, 2014, JAMA PEDIATR, V168, P178, DOI 10.1001/jamapediatrics.2013.4200
   Meyer C, 2005, J CLIN ENDOCR METAB, V90, P4630, DOI 10.1210/jc.2004-1487
   Moran LJ, 2013, HUM REPROD, V28, P2276, DOI 10.1093/humrep/det256
   Moran LJ, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007506.pub3
   Moran LJ, 2013, J ACAD NUTR DIET, V113, P520, DOI 10.1016/j.jand.2012.11.018
   Moran LJ, 2010, HUM REPROD UPDATE, V16, P347, DOI 10.1093/humupd/dmq001
   Moran LJ, 2009, FERTIL STERIL, V92, P1966, DOI 10.1016/j.fertnstert.2008.09.018
   Nieuwenhuis-Ruifrok AE, 2009, HUM REPROD UPDATE, V15, P57, DOI 10.1093/humupd/dmn043
   Ogden CL, 2014, JAMA-J AM MED ASSOC, V311, P806, DOI 10.1001/jama.2014.732
   Ouchi N, 2011, NAT REV IMMUNOL, V11, P85, DOI 10.1038/nri2921
   Pasquali R, 2006, BJOG-INT J OBSTET GY, V113, P1148, DOI 10.1111/j.1471-0528.2006.00990.x
   PASQUALI R, 1994, METABOLISM, V43, P706, DOI 10.1016/0026-0495(94)90118-X
   PASQUALI R, 1989, J CLIN ENDOCR METAB, V68, P173, DOI 10.1210/jcem-68-1-173
   Pelusi B, 2004, Minerva Ginecol, V56, P41
   Qatanani M, 2007, GENE DEV, V21, P1443, DOI 10.1101/gad.1550907
   Rachon D, 2010, MOL CELL ENDOCRINOL, V316, P172, DOI 10.1016/j.mce.2009.09.026
   Rasmussen CB, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00140
   Roessler KK, 2013, ACTA OBSTET GYN SCAN, V92, P272, DOI 10.1111/aogs.12064
   Sam Susan, 2007, Obes Manag, V3, P69, DOI 10.1089/obe.2007.0019
   Scott-Pillai R, 2013, BJOG-INT J OBSTET GY, V120, P932, DOI 10.1111/1471-0528.12193
   Shorakae S, 2014, INTERN MED J, V44, P720, DOI 10.1111/imj.12495
   Sirmans SM, 2014, CLIN EPIDEMIOL, V6, P1, DOI 10.2147/CLEP.S37559
   Sprung VS, 2013, MED SCI SPORT EXER, V45, P2234, DOI 10.1249/MSS.0b013e31829ba9a1
   Stepto NK, 2013, HUM REPROD, V28, P777, DOI 10.1093/humrep/des463
   Straznicky NE, 2009, DIABETES, V58, P1126, DOI 10.2337/db08-1595
   Straznicky NE, 2009, AM J CLIN NUTR, V89, P27, DOI 10.3945/ajcn.2008.26299
   Studen KB, 2013, FRONT HORM RES, V40, P64, DOI 10.1159/000341838
   Sverrisdóttir YB, 2008, AM J PHYSIOL-ENDOC M, V294, pE576, DOI 10.1152/ajpendo.00725.2007
   Tang T, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003053.pub5
   Targher G, 2009, J ENDOCRINOL INVEST, V32, P695, DOI [10.1007/BF03345743, 10.3275/6375]
   Taslim S, 2009, ANN ACAD MED SINGAP, V38, P29
   Teede H, 2010, BMC MED, V8, DOI 10.1186/1741-7015-8-41
   Teede HJ, 2007, TRENDS ENDOCRIN MET, V18, P273, DOI 10.1016/j.tem.2007.08.001
   Teede HJ, 2013, OBESITY, V21, P1526, DOI 10.1002/oby.20213
   Teede HJ, 2011, MED J AUSTRALIA, V195, pS69, DOI 10.5694/mja11.10915
   Vosnakis C, 2013, GYNECOL ENDOCRINOL, V29, P242, DOI 10.3109/09513590.2012.736557
   WHO Consultation on Obesity, 2000, Obesity: preventing and managing the global epidemic. Report of a who consultation, V894
   Wisse BE, 2004, J AM SOC NEPHROL, V15, P2792, DOI 10.1097/01.ASN.0000141966.69934.21
   Wright CE, 2004, INT J OBESITY, V28, P1026, DOI 10.1038/sj.ijo.0802661
   Yildiz BO, 2008, J CLIN ENDOCR METAB, V93, P162, DOI 10.1210/jc.2007-1834
   Yildiz BO, 2012, HUM REPROD, V27, P3067, DOI 10.1093/humrep/des232
   Yu CKH, 2006, BJOG-INT J OBSTET GY, V113, P1117, DOI 10.1111/j.1471-0528.2006.00991.x
   Yucel A, 2006, EUR J OBSTET GYN R B, V126, P81, DOI 10.1016/j.ejogrb.2005.11.012
NR 118
TC 69
Z9 87
U1 0
U2 19
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0391-1977
EI 1827-1634
J9 MINERVA ENDOCRINOL
JI Minerva Endocrinol.
PD MAR
PY 2015
VL 40
IS 1
BP 37
EP 51
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CE7PQ
UT WOS:000352034200005
PM 25411807
DA 2025-06-11
ER

PT J
AU Irandoust, K
   Taheri, M
   Chtourou, H
   Nikolaidis, PT
   Rosemann, T
   Knechtle, B
AF Irandoust, Khadijah
   Taheri, Morteza
   Chtourou, Hamdi
   Nikolaidis, Pantelis Theo
   Rosemann, Thomas
   Knechtle, Beat
TI Effect of Time-of-Day-Exercise in Group Settings on Level of Mood and
   Depression of Former Elite Male Athletes
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE time-of-day; mood; depression; elite athlete
ID SYMPTOMS; OBESITY; SLEEP
AB Since the prevalence of depression is high among athletes at the end of their athletic career, the purpose of this study was to investigate the effect of time-of-day-exercise in group settings on the level of the mood and depression of former elite male athletes.Out of 187 volunteers referring to the sports counseling clinic, 71 retired male athletes who had a national championship record were randomly divided into two morning and evening exercise groups. The inclusion criteria were severe depression (high score in the Beck Depression Inventory-II), the age range of 50 to 60 years, the absence of metabolic syndrome, and the body mass index (BMI) between 28 and 35. All body composition variables were measured using body composition analysis (In Body 320; Korea). The second stage was the collection of data after three months (completion of the training protocol). After data collection, independent and dependent t-tests were used to analyze the data. The results indicated that both groups had a significant improvement in depression compared to the pre-test (p <= 0.05), while there was no significant difference between the two groups (p >= 0.05). The overall conclusion is that exercise at different times of the morning or evening can improve the psychological state and reduce depression.
C1 [Irandoust, Khadijah; Taheri, Morteza] Imam Khomeini Int Univ, Dept Sport Sci, Qazvin 3414896818, Iran.
   [Chtourou, Hamdi] Observ Natl Sport, UR18JS01, Act Phys Sport & Sante, Tunis 1003, Tunisia.
   [Chtourou, Hamdi] Univ Sfax, Inst Superieur Sport & Educ Phys Sfax, Sfax 3000, Tunisia.
   [Nikolaidis, Pantelis Theo] Exercise Physiol Lab, Nikaia 18450, Greece.
   [Rosemann, Thomas] Univ Zurich, Inst Primary Care, CH-8091 Zurich, Switzerland.
   [Knechtle, Beat] Medbase St Gallen Vadianplatz, CH-9001 St Gallen, Switzerland.
C3 Imam Khomeini International University; Universite de Sfax; University
   of Zurich
RP Knechtle, B (corresponding author), Medbase St Gallen Vadianplatz, CH-9001 St Gallen, Switzerland.
EM irandoust@soc.ikiu.ac.ir; m.taheri@soc.ikiu.ac.ir; h_chtourou@yahoo.fr;
   pademil@hotmail.com; thomas.rosemann@usz.ch; beat.knechtle@hispeed.ch
RI Knechtle, Beat/ABC-5529-2020; irandoust, khadijeh/ABH-3519-2021;
   Morteza, Taheri/N-5170-2016; Chtourou, Hamdi/AEZ-6215-2022; Nikolaidis,
   Pantelis/K-8664-2017
OI Irandoust, Khadijeh/0000-0001-5839-9753; Knechtle,
   Beat/0000-0002-2412-9103; Morteza, Taheri/0000-0001-8031-3792; Rosemann,
   Thomas/0000-0002-6436-6306; Chtourou, Hamdi/0000-0002-5482-9151;
   Nikolaidis, Pantelis/0000-0001-8030-7122
CR Abadi H.A.Y., 2018, INT J SPORT STUD HLT, V1, pe64316
   Albuquerque FN, 2010, J AM COLL CARDIOL, V56, P1432, DOI 10.1016/j.jacc.2010.03.099
   Amirsasan R, 2018, INT J SPORT STUD HLT, V1, DOI [10.5812/intjssh.83810, DOI 10.5812/INTJSSH.83810]
   Bartholomew JB, 2005, MED SCI SPORT EXER, V37, P2032, DOI 10.1249/01.mss.0000178101.78322.dd
   BERGER BG, 1992, PERCEPT MOTOR SKILL, V75, P1331, DOI 10.2466/PMS.75.8.1331-1343
   Chtourou H., 2014, J Athl Enhanc, V4, P90
   Chtourou H, 2012, J STRENGTH COND RES, V26, P1984, DOI 10.1519/JSC.0b013e31825770a7
   Chtourou H, 2012, J STRENGTH COND RES, V26, P697, DOI 10.1519/JSC.0b013e3182281c87
   Chtourou H, 2012, J STRENGTH COND RES, V26, P217, DOI 10.1519/JSC.0b013e31821d5e8d
   Cooper SB, 2011, PHYSIOL BEHAV, V103, P431, DOI 10.1016/j.physbeh.2011.03.018
   Eime RM, 2013, INT J BEHAV NUTR PHY, V10, DOI 10.1186/1479-5868-10-98
   Emami Mohammadreza, 2018, Indian J Endocrinol Metab, V22, P515, DOI 10.4103/ijem.IJEM_83_18
   Filbay SR, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2017-017785
   Fox KR, 1999, PUBLIC HEALTH NUTR, V2, P411, DOI 10.1017/S1368980099000567
   Giannone ZA, 2017, INT J SOC PSYCHIATR, V63, P598, DOI 10.1177/0020764017724184
   Irandoust K., 2017, Asian Journal of Sports Medicine, V8, pe13311, DOI 10.5812/asjsm.13311
   Irandoust K, 2015, J PHYS THER SCI, V27, P433, DOI 10.1589/jpts.27.433
   Jafari M., 2018, INT J SPORT STUD HLT, V1, pe64336, DOI [10.5812/intjssh.64336, DOI 10.5812/INTJSSH.64336]
   Kalak N, 2012, J ADOLESCENT HEALTH, V51, P615, DOI 10.1016/j.jadohealth.2012.02.020
   Kujala UM, 1996, JAMA-J AM MED ASSOC, V276, P216, DOI 10.1001/jama.276.3.216
   LeUnes A, 2000, J APPL SPORT PSYCHOL, V12, P5, DOI 10.1080/10413200008404210
   Marcus B.H., 2018, Motivating people to be physically active
   Murray C.J.L., 1996, The global burden of disease: a comprehensive assessment of mortality and disability from diseases, injuries, and risk factors in 1990 and projected to 2020: Summary, VVolume xxxii, P990
   Nabilpour M., 2018, INT J SPORT STUD HLT, V1, DOI [10.5812/intjssh.81874, DOI 10.5812/INTJSSH.81874]
   Naghavi N, 2018, INT J SPORT STUD HLT, V1, DOI DOI 10.5812/INTJSSH.83935
   Otto M.W., 2011, EXERCISE MOOD ANXIET
   Peluso Marco Aurélio Monteiro, 2005, Clinics, V60, P61, DOI 10.1590/S1807-59322005000100012
   Randler C, 2011, PSYCHOL HEALTH MED, V16, P29, DOI 10.1080/13548506.2010.521564
   Roberts RE, 2000, AM J EPIDEMIOL, V152, P163, DOI 10.1093/aje/152.2.163
   Sarkar S., 2019, INT J SPORT STUDIES, V2, DOI [10.5812/INTJSSH.88855, DOI 10.5812/INTJSSH.88855]
   Sayyah M, 2011, BIOSCIENCES BIOTECHN, V8, P367, DOI DOI 10.13005/bbra/875
   Souissi H, 2012, PEDIATR EXERC SCI, V24, P84, DOI 10.1123/pes.24.1.84
   Teramoto M, 2010, J SCI MED SPORT, V13, P410, DOI 10.1016/j.jsams.2009.04.010
   TRINE MR, 1995, SPORTS MED, V20, P328, DOI 10.2165/00007256-199520050-00004
   Vogelzangs N, 2008, ARCH GEN PSYCHIAT, V65, P1386, DOI 10.1001/archpsyc.65.12.1386
   Wegner M, 2014, CNS NEUROL DISORD-DR, V13, P1002, DOI 10.2174/1871527313666140612102841
NR 36
TC 20
Z9 22
U1 1
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD OCT
PY 2019
VL 16
IS 19
AR 3541
DI 10.3390/ijerph16193541
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA JK3MF
UT WOS:000494748600037
PM 31546685
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rendina, D
   Ippolito, R
   De Filippo, G
   Muscariello, R
   De Palma, D
   De Bonis, S
   di Cola, MS
   Benvenuto, D
   Galderisi, M
   Strazzullo, P
   Galletti, F
AF Rendina, Domenico
   Ippolito, Renato
   De Filippo, Gianpaolo
   Muscariello, Riccardo
   De Palma, Daniela
   De Bonis, Silvana
   di Cola, Michele Schiano
   Benvenuto, Domenico
   Galderisi, Maurizio
   Strazzullo, Pasquale
   Galletti, Ferruccio
TI Risk factors for silent myocardial ischemia in patients with
   well-controlled essential hypertension
SO INTERNAL AND EMERGENCY MEDICINE
LA English
DT Article
DE Asymptomatic coronary artery disease; Blood pressure control; 24-h
   ambulatory blood pressure monitoring; 24-h ambulatory electrocardiogram
ID ST-SEGMENT DEPRESSION; CORONARY-ARTERY-DISEASE; BLOOD-PRESSURE;
   METABOLIC SYNDROME; CLINICAL ELECTROCARDIOGRAPHY; CIRCADIAN VARIATION;
   INDEPENDENT PREDICTOR; INPATIENT POPULATION; CARDIAC ISCHEMIA; PULSE
   PRESSURE
AB Silent myocardial ischemia (SMI) is frequently observed in patients with essential hypertension (EH). The major risk factor for SMI is uncontrolled blood pressure (BP), but SMI is also observed in patients with well-controlled BP. To evaluate the prevalence of SMI and the factors associated with SMI in EH patients with well-controlled BP. The medical records of 859 EH patients who underwent simultaneous 24-h ambulatory blood pressure monitoring (ABPM) and 24-h ambulatory electrocardiogram recording (AECG) were retrospectively evaluated. Each SMI episode was characterized by: (a) ST segment depression >0.5 mm; (b) duration of ST segment depression > 60 s; and (c) reversibility of the ST segment depression. Overall 126 EH patients (14.7 %) had at least one episode of SMI. The SMI events were more frequent among patients with poorly controlled compared to those with well-controlled BP [86/479 (17.95 %) vs. 40/380 (10.52 %), p < 0.01]. Among EH patients with well-controlled BP, current and past smoking as well as the presence of an additional metabolic syndrome (MetS) constitutive element (obesity, impaired fasting glucose level or dyslipidemia) were significantly associated with the occurrence of SMI. In all EH patients with well-controlled BP and AECG evidence of SMI, there were one or more coronary artery stenotic lesions greater than 50 % found at coronary angiography. In EH patients who are current smokers, or have one or more additional components of a MetS there is markedly reduced benefit associated with good BP control with regard to the occurrence of myocardial ischemia: in this patient category, an AECG may help detect this condition.
C1 [Rendina, Domenico; Ippolito, Renato; De Filippo, Gianpaolo; Muscariello, Riccardo; De Palma, Daniela; di Cola, Michele Schiano; Strazzullo, Pasquale; Galletti, Ferruccio] Univ Naples Federico II, Dept Clin Med & Surg, Via Pansini 5, I-80131 Naples, Italy.
   [Rendina, Domenico; De Bonis, Silvana; Benvenuto, Domenico] Spinelli Hosp, Cosenza, Italy.
   [De Filippo, Gianpaolo] Hop Bicetre, AP HP, Unite Diabet Hypertens Nutr Adolescent, Le Kremlin Bicetre, France.
   [De Bonis, Silvana] Ferrari Hosp, Cardiol Unit, Cosenza, Italy.
   [Galderisi, Maurizio] Univ Naples Federico II, Dept Adv Clin Sci, Naples, Italy.
C3 University of Naples Federico II; Assistance Publique Hopitaux Paris
   (APHP); Hopital Universitaire Bicetre - APHP; Universite Paris Saclay;
   Hopital Universitaire Antoine-Beclere - APHP; University of Naples
   Federico II
RP Rendina, D (corresponding author), Univ Naples Federico II, Dept Clin Med & Surg, Via Pansini 5, I-80131 Naples, Italy.; Rendina, D (corresponding author), Spinelli Hosp, Cosenza, Italy.
EM domenico.rendina@unina.it
RI Muscariello, Riccardo/AAW-1394-2020; Galletti, Ferruccio/B-8923-2013;
   De+Filippo, Gianpaolo/AAE-5584-2019
OI Galletti, Ferruccio/0000-0001-7556-0254; Rendina,
   Domenico/0000-0002-0331-0392
FU Stroder/Societa Italiana dell'Osteoporosi del Metabolismo Minerale e
   delle Malattie dello Scheletro; Societa Italiana Medicina Interna
FX The authors are grateful to the owners and the medical director of the
   Spinelli Hospital who granted the free use of the facilities and
   services required to conduct the study. This study was supported by
   unrestricted grants from Stroder/Societa Italiana dell'Osteoporosi del
   Metabolismo Minerale e delle Malattie dello Scheletro (to DR) and
   Societa Italiana Medicina Interna (to RI).
CR Asmar R, 1996, AM J CARDIOL, V77, P384, DOI 10.1016/S0002-9149(97)89369-1
   Boon D, 2000, J HYPERTENS, V18, P1355, DOI 10.1097/00004872-200018100-00002
   Boon D, 2003, HYPERTENSION, V41, P476, DOI 10.1161/01.HYP.0000054980.69529.14
   Cohn PF, 2003, CIRCULATION, V108, P1263, DOI 10.1161/01.CIR.0000088001.59265.EE
   Conti CR, 2012, J AM COLL CARDIOL, V59, P435, DOI 10.1016/j.jacc.2011.07.050
   D'Negri Carlos E, 2006, BMC Cardiovasc Disord, V6, P1, DOI 10.1186/1471-2261-6-1
   De Lorenzo A, 2015, CURR DIABETES REV, V11, P98, DOI 10.2174/1573399811666150108122443
   DEANFIELD JE, 1984, AM J CARDIOL, V54, P1195, DOI 10.1016/S0002-9149(84)80066-1
   DEEDWANIA PC, 1990, CIRCULATION, V81, P748, DOI 10.1161/01.CIR.81.3.748
   Ehler D, 2001, J AM SOC ECHOCARDIOG, V14, P77, DOI 10.1067/mje.2001.109922
   Esberger D, 2002, BRIT MED J, V324, P662, DOI 10.1136/bmj.324.7338.662
   FOLEY DP, 1994, PROG CARDIOVASC DIS, V36, P363, DOI 10.1016/S0033-0620(05)80027-1
   Gallotta G, 2008, INT J CARDIOL, V124, P351, DOI 10.1016/j.ijcard.2006.03.096
   Gibbons RJ, 2002, CIRCULATION, V106, P1883, DOI 10.1161/01.CIR.0000034670.06526.15
   Goodacre S, 2002, BRIT MED J, V324, P594, DOI 10.1136/bmj.324.7337.594
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Gutterman DD, 2009, CIRC J, V73, P785, DOI 10.1253/circj.CJ-08-1209
   HEDBLAD B, 1992, HYPERTENSION, V20, P32, DOI 10.1161/01.HYP.20.1.32
   Kadish AH, 2001, CIRCULATION, V104, P3169
   Kannel W B, 1986, Cardiol Clin, V4, P583
   Li Jing, 2010, J Cardiovasc Dis Res, V1, P23, DOI 10.4103/0975-3583.59981
   Mancia G, 2003, J HYPERTENS, V21, P1011, DOI 10.1097/01.hjh.0000059051.65882.32
   Mancia G, 2007, J HYPERTENS, V25, P1751, DOI 10.1097/HJH.0b013e3282f0580f
   Mancia G, 2013, EUR HEART J, V34, P2159, DOI 10.1093/eurheartj/eht151
   MARGOLIS JR, 1973, AM J CARDIOL, V32, P1, DOI 10.1016/S0002-9149(73)80079-7
   Meek S, 2002, BRIT MED J, V324, P415, DOI 10.1136/bmj.324.7334.415
   Melina D, 1993, Minerva Med, V84, P301
   MIRVIS DM, 1990, AM J CARDIOL, V66, P699, DOI 10.1016/0002-9149(90)91133-Q
   Mitchell GF, 1997, CIRCULATION, V96, P4254
   MORRIS JJ, 1990, AM HEART J, V120, P746, DOI 10.1016/0002-8703(90)90048-3
   MULLER JE, 1987, CIRCULATION, V75, P131, DOI 10.1161/01.CIR.75.1.131
   Nadir MA, 2012, J AM COLL CARDIOL, V60, P960, DOI 10.1016/j.jacc.2012.04.049
   O'Brien E, 2003, J HYPERTENS, V21, P821, DOI 10.1097/00004872-200305000-00001
   PANZA JA, 1991, NEW ENGL J MED, V325, P986, DOI 10.1056/NEJM199110033251402
   PEPINE CJ, 1994, J AM COLL CARDIOL, V24, P1, DOI 10.1016/0735-1097(94)90534-7
   Rendina D, 2012, J ENDOCRINOL INVEST, V35, P407, DOI 10.3275/7842
   Rendina D, 2009, NEPHROL DIAL TRANSPL, V24, P900, DOI 10.1093/ndt/gfn548
   Rocco M B, 1986, Cardiol Clin, V4, P659
   ROCCO MB, 1987, CIRCULATION, V75, P395, DOI 10.1161/01.CIR.75.2.395
   SAPIN PM, 1991, J AM COLL CARDIOL, V18, P127, DOI 10.1016/S0735-1097(10)80228-1
   Schutte R, 2013, AM J HYPERTENS, V26, P665, DOI 10.1093/ajh/hps119
   Stagmo M, 2005, EUR J CARDIOV PREV R, V12, P478, DOI 10.1097/01.hjr.0000176511.22284.c1
   Stramba-Badiale M, 1998, J HYPERTENS, V16, P681, DOI 10.1097/00004872-199816050-00016
   Struthers AD, 2013, HYPERTENSION, V62, P236, DOI 10.1161/HYPERTENSIONAHA.113.01586
   TAKACH TJ, 1986, ANN THORAC SURG, V42, P31, DOI 10.1016/S0003-4975(10)61832-2
   Thomopoulos C, 2014, J HYPERTENS, V32, P2305, DOI 10.1097/HJH.0000000000000380
   Uen S, 2003, J HYPERTENS, V21, P977, DOI 10.1097/00004872-200305000-00023
   Uen S, 2006, BLOOD PRESS MONIT, V11, P173, DOI 10.1097/01.mbp.0000209075.38331.5f
   Veillet-Chowdhury M, 2015, EXPERT REV CARDIOVAS, V13, P589, DOI 10.1586/14779072.2015.1047764
   WILLICH SN, 1989, CIRCULATION, V80, P853, DOI 10.1161/01.CIR.80.4.853
   Wimmer NJ, 2013, PROG CARDIOVASC DIS, V56, P195, DOI 10.1016/j.pcad.2013.07.001
   ZEHENDER M, 1992, CIRCULATION, V85, P1808, DOI 10.1161/01.CIR.85.5.1808
   Zidek W, 2009, CARDIOVASC DIABETOL, V8, DOI 10.1186/1475-2840-8-51
NR 53
TC 4
Z9 5
U1 0
U2 3
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1828-0447
EI 1970-9366
J9 INTERN EMERG MED
JI Intern. Emerg. Med.
PD MAR
PY 2017
VL 12
IS 2
BP 171
EP 179
DI 10.1007/s11739-016-1527-2
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EM6VL
UT WOS:000395450400005
PM 27565986
DA 2025-06-11
ER

PT J
AU Zeman, M
   Jirak, R
   Jachymova, M
   Vecka, M
   Tvrzicka, E
   Zak, A
AF Zeman, Miroslav
   Jirak, Roman
   Jachymova, Marie
   Vecka, Marek
   Tvrzicka, Eva
   Zak, Ales
TI Leptin, adiponectin, leptin to adiponectin ratio and insulin resistance
   in depressive women
SO NEUROENDOCRINOLOGY LETTERS
LA English
DT Article
DE depression; leptin; adiponectin; insulin resistance; leptin to
   adiponectin ratio; metabolic syndrome
ID BINGE-EATING DISORDER; MAJOR DEPRESSION; CARDIOVASCULAR-DISEASE;
   GLUCOSE-HOMEOSTASIS; PLASMA LEPTIN; ASSOCIATION; OBESITY; TYPE-2;
   SENSITIVITY; SEROTONIN
AB BACKGROUND: Depressive disorder (DD) is associated with an increased risk of type 2 diabetes mellitus (DM2) and cardiovascular disease (CVD). It was suggested, that metabolic syndrome (MetS), cluster of metabolic and hormonal changes, such as insulin resistence (IR), abdominal obesity, dyslipidemia, arterial hypertension and elevated fasting glycaemia, could stand behind the connection. Recent findings have shown, that adipocytokines leptin and adiponectin might play a role in both depression and MetS.
   AIM: The aim of this pilot study was to observe the plasma concentrations of leptin, adiponectin, leptin-to-adiponectin ratio and indices of IR in women with depressive disorder.
   MATERIALS AND METHODS: The plasma leptin, adiponectin, parameters of lipid and glucose homeostasis and indices of IR were investigated in a group of 38 women with DD. The results were compared with those of 38 healthy women of the control group, matched for age.
   RESULTS: Depressive women differed significantly from the controls in higher concentrations of Plasma leptin (p<0.05), insulin (p<0.01), C-peptide (p<0.01), value of HOMA-IR (p<0.01), and the leptin-to-adiponectin ratio (p<0.05). he QUICKI index of insulin sensitivity was lower (p<0.01). HAM-D score of DID cases correlated negatively with adiponectin (r=-0.3505; p<0.05), independently of HOMA-IR. We have not found in DD group any differences between the drug free patients and those treated either with escitaloprame alone or in the combination with :mirtazapine.
   CONCLUSIONS: The results of the pilot study presented support the hypothesis that at least part of DD cases has increased leptin serum levels and certain features of MetS. It could be the factor connecting depression with an increased risk of either DM2 or CVD.
C1 [Zeman, Miroslav] Charles Univ Prague, Fac Med 1, Dept Internal Med 4, Prague 12808 2, Czech Republic.
   [Jirak, Roman] Charles Univ Prague, Fac Med 1, Dept Psychiat, Prague 12808 2, Czech Republic.
C3 Charles University Prague; Charles University Prague; General University
   Hospital Prague
RP Zeman, M (corresponding author), Charles Univ Prague, Fac Med 1, Dept Internal Med 4, U Nemocnice 2, Prague 12808 2, Czech Republic.
EM mirozem@seznam.cz
RI Jirak, Roman/O-1658-2017; Vecka, Marek/A-3560-2008; Zak,
   Ales/G-8318-2016; Tvrzicka, Eva/Q-6300-2016; Zeman, Miroslav/J-5281-2016
OI Jirak, Roman/0000-0002-8061-9668; Vecka, Marek/0000-0002-3269-1817; Zak,
   Ales/0000-0002-1698-6068; Tvrzicka, Eva/0000-0003-0794-8454; Zeman,
   Miroslav/0000-0001-5338-603X
FU IGA Ministry of Health of Czech Republic [NR 8806-3]
FX This work was supported by research grant IGA Ministry of Health of
   Czech Republic, NR 8806-3.
CR Atmaca M, 2002, ARCH ANDROLOGY, V48, P345, DOI 10.1080/01485010290099192
   Baldwin DS, 2007, ANN PHARMACOTHER, V41, P1583, DOI 10.1345/aph.1K089
   Bastard JP, 2006, EUR CYTOKINE NETW, V17, P4
   Bates SH, 2003, TRENDS ENDOCRIN MET, V14, P447, DOI 10.1016/j.tem.2003.10.003
   Bouloumié A, 1999, FASEB J, V13, P1231, DOI 10.1096/fasebj.13.10.1231
   Brown ES, 2004, BIOL PSYCHIAT, V55, P1, DOI 10.1016/S0006-3223(03)00473-6
   Chadwick W, 2007, J PHARM PHARMACOL, V59, P95, DOI 10.1211/jpp.59.1.0013
   Charnay Y, 2000, NEUROSCI LETT, V283, P89, DOI 10.1016/S0304-3940(00)00951-4
   Chiba M, 2000, METABOLISM, V49, P1145, DOI 10.1053/meta.2000.8611
   Convit A, 1997, NEUROBIOL AGING, V18, P131, DOI 10.1016/S0197-4580(97)00001-8
   Cuijpers P, 2007, ACTA PSYCHIAT SCAND, V115, P229, DOI 10.1111/j.1600-0447.2006.00851.x
   den Heijer T, 2003, DIABETOLOGIA, V46, P1604, DOI 10.1007/s00125-003-1235-0
   Deuschle M, 1996, HORM METAB RES, V28, P714, DOI 10.1055/s-2007-979885
   Dryden S, 1999, HORM METAB RES, V31, P363, DOI 10.1055/s-2007-978755
   Dubey Laxman, 2006, Exp Clin Cardiol, V11, P269
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Fisar Z, 2008, NEUROENDOCRINOL LETT, V29, P17
   Gecici O, 2005, PSYCHIAT CLIN NEUROS, V59, P736, DOI 10.1111/j.1440-1819.2005.01445.x
   Guerdjikova AI, 2008, HUM PSYCHOPHARM CLIN, V23, P1, DOI 10.1002/hup.899
   GUPTA B, 1992, INDIAN J MED RES-B, V96, P65
   Hainer V, 2006, ANN NY ACAD SCI, V1083, P252, DOI 10.1196/annals.1367.017
   Han SH, 2007, J AM COLL CARDIOL, V49, P531, DOI 10.1016/j.jacc.2006.08.061
   Harvey J, 2003, MOL NEUROBIOL, V28, P245, DOI 10.1385/MN:28:3:245
   Harvey J, 2007, J NEUROCHEM, V100, P307, DOI 10.1111/j.1471-4159.2006.04205.x
   Havel PJ, 2004, DIABETES, V53, pS143, DOI 10.2337/diabetes.53.2007.S143
   Hindmarch I., 2002, European Psychiatry, V17, P294, DOI 10.1016/S0924-9338(02)00653-3
   Hotta K, 2000, ARTERIOSCL THROM VAS, V20, P1595, DOI 10.1161/01.ATV.20.6.1595
   Hung YJ, 2007, CLIN ENDOCRINOL, V67, P784, DOI 10.1111/j.1365-2265.2007.02963.x
   Inoue M, 2006, METABOLISM, V55, P1248, DOI 10.1016/j.metabol.2006.05.010
   Kalra SP, 2008, PEPTIDES, V29, P127, DOI 10.1016/j.peptides.2007.10.017
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   Kauffman RP, 2005, GYNECOL ENDOCRINOL, V21, P129, DOI 10.1080/09513590500216800
   Kempermann G, 2003, BIOL PSYCHIAT, V54, P499, DOI 10.1016/S0006-3223(03)00319-6
   Kessler RC, 2003, JAMA-J AM MED ASSOC, V289, P3095, DOI 10.1001/jama.289.23.3095
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Konstantinides S, 2001, J CLIN INVEST, V108, P1533, DOI 10.1172/JCI13143
   Kraus T, 2001, NEUROENDOCRINOLOGY, V73, P243, DOI 10.1159/000054641
   Kubota N, 2007, CELL METAB, V6, P55, DOI 10.1016/j.cmet.2007.06.003
   Laimer M, 2006, J CLIN PSYCHIAT, V67, P421, DOI 10.4088/JCP.v67n0313
   Lau DCW, 2005, AM J PHYSIOL-HEART C, V288, pH2031, DOI 10.1152/ajpheart.01058.2004
   Lawlor DA, 2003, BRIT MED J, V327, P1383, DOI 10.1136/bmj.327.7428.1383
   Lee ES, 2005, OBES RES, V13, P320, DOI 10.1038/oby.2005.43
   Leo R, 2006, NEUROSCI LETT, V407, P211, DOI 10.1016/j.neulet.2006.08.043
   Lu XY, 2007, CURR OPIN PHARMACOL, V7, P648, DOI 10.1016/j.coph.2007.10.010
   Lu XY, 2006, P NATL ACAD SCI USA, V103, P1593, DOI 10.1073/pnas.0508901103
   Malhi GS, 2005, ACTA PSYCHIAT SCAND, V111, P94, DOI 10.1111/j.1600-0447.2004.00475.x
   Mamalakis G, 2006, PHARMACOL BIOCHEM BE, V85, P474, DOI 10.1016/j.pbb.2006.10.008
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McCaffery JM, 2003, PSYCHOSOM MED, V65, P490, DOI 10.1097/01.PSY.0000041545.52924.82
   McElroy SL, 2006, J CLIN PSYCHIAT, V67, P1897, DOI 10.4088/JCP.v67n1209
   McIntyre RS, 2006, EXPERT OPIN DRUG SAF, V5, P157, DOI 10.1517/14740338.5.1.157
   Minokoshi Y, 2004, NATURE, V428, P569, DOI 10.1038/nature02440
   Mittal VA, 2011, PSYCHIAT RES, V189, P158, DOI 10.1016/j.psychres.2011.06.006
   Musselman DL, 2003, BIOL PSYCHIAT, V54, P317, DOI 10.1016/S0006-3223(03)00569-9
   Musselman DL, 1998, ARCH GEN PSYCHIAT, V55, P580, DOI 10.1001/archpsyc.55.7.580
   Narita K, 2008, PROG NEURO-PSYCHOPH, V32, P124, DOI 10.1016/j.pnpbp.2007.07.022
   Narita K, 2006, PROG NEURO-PSYCHOPH, V30, P1159, DOI 10.1016/j.pnpbp.2006.03.030
   NELSON JC, 1981, AM J PSYCHIAT, V138, P1
   Norata GD, 2007, STROKE, V38, P2844, DOI 10.1161/STROKEAHA.107.485540
   Okamura F, 2000, METABOLISM, V49, P1255, DOI 10.1053/meta.2000.9515
   Pan A, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001392
   Parhami F, 2001, CIRC RES, V88, P954, DOI 10.1161/hh0901.090975
   Pirkola SP, 2005, SOC PSYCH PSYCH EPID, V40, P1, DOI 10.1007/s00127-005-0848-7
   Rasgon NL, 2005, NEUROBIOL AGING, V26, pS103
   Rasgon NL, 2005, BIPOLAR DISORD, V7, P246, DOI 10.1111/j.1399-5618.2005.00201.x
   Sheline YI, 1996, P NATL ACAD SCI USA, V93, P3908, DOI 10.1073/pnas.93.9.3908
   SMITH RS, 1991, MED HYPOTHESES, V35, P298, DOI 10.1016/0306-9877(91)90272-Z
   Spranger J, 2003, LANCET, V361, P226, DOI 10.1016/S0140-6736(03)12255-6
   *UZIS, 2007, CZECH HLTH STAT YB 2
   Vanhala M J, 1997, J Cardiovasc Risk, V4, P291, DOI 10.1097/00043798-199708000-00010
   Weber-Hamann B, 2007, J PSYCHIATR RES, V41, P344, DOI 10.1016/j.jpsychires.2006.01.002
   Westbroek I, 2007, J CELL BIOCHEM, V101, P360, DOI 10.1002/jcb.21177
   Weyer C, 2001, J CLIN ENDOCR METAB, V86, P1930, DOI 10.1210/jc.86.5.1930
   WINOKUR A, 1988, AM J PSYCHIAT, V145, P325
   Wulsin LR, 1999, PSYCHOSOM MED, V61, P6, DOI 10.1097/00006842-199901000-00003
   Xita N, 2007, METABOLISM, V56, P766, DOI 10.1016/j.metabol.2007.01.008
   Yamauchi T, 2001, NAT MED, V7, P941, DOI 10.1038/90984
   ZHANG YY, 1994, NATURE, V372, P425, DOI 10.1038/372425a0
NR 78
TC 56
Z9 59
U1 0
U2 21
PU MAGHIRA & MAAS PUBLICATIONS
PI MUNSBACH
PA MAGHIRA & MAAS S A R L, 6C, RUE GABRIEL LIPPMANN, L-5365 MUNSBACH,
   LUXEMBOURG
SN 0172-780X
EI 2354-4716
J9 NEUROENDOCRINOL LETT
JI Neuroendocrinol. Lett.
PY 2009
VL 30
IS 3
BP 387
EP 395
PG 9
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 525FH
UT WOS:000272199300017
PM 19855365
DA 2025-06-11
ER

PT J
AU DeVallance, ER
   Branyan, KW
   Olfert, IM
   Pistilli, EE
   Bryner, RW
   Kelley, EE
   Frisbee, JC
   Chantler, PD
AF DeVallance, Evan R.
   Branyan, Kayla W.
   Olfert, I. Mark
   Pistilli, Emidio E.
   Bryner, Randall W.
   Kelley, Eric E.
   Frisbee, Jefferson C.
   Chantler, Paul D.
TI Chronic stress induced perivascular adipose tissue impairment of aortic
   function and the therapeutic effect of exercise
SO EXPERIMENTAL PHYSIOLOGY
LA English
DT Article
DE aldosterone; aortic stiffness; chronic stress; exercise; inflammation;
   metabolic syndrome; perivascular adipose tissue
ID CHRONIC MILD STRESS; SYMPATHETIC-NERVOUS-SYSTEM; NITRIC-OXIDE SYNTHASE;
   NF-KAPPA-B; TNF-ALPHA; ARTERIAL STIFFNESS; OXIDATIVE STRESS; VASCULAR
   DYSFUNCTION; INDEPENDENT PREDICTOR; METABOLIC SYNDROME
AB New Findings
   What is the central question of this study? Thoracic perivascular adipose tissue (tPVAT) is known to, in part, regulate aortic function: what are the effects of unpredictable chronic mild stress (UCMS) on the tPVAT regulation of aortic function and what is the role of exercise training in alleviating the potential negative actions of UCMS on tPVAT?
   What is the main finding and its importance? UCMS causes tPVAT to disrupt endothelium-dependent dilatation, increases inflammatory cytokine production and diminishes tPVAT-adiponectin. Exercise training proved efficacious in preventing tPVAT-mediated disruption of aortic function. The data support a tPVAT mechanism through which chronic stress negatively impacts vascular health, which adds to our knowledge of how psychological disorders might increase the risk of cardiovascular disease.
   Chronic stress is a major risk for cardiovascular disease. Perivascular adipose tissue (PVAT) has been shown to regulate vascular function; however, the impact of chronic stress and the comorbidity of metabolic syndrome (MetS) on thoracic (t)PVAT is unknown. Additionally, aerobic exercise training (AET) is known to combat the pathology of MetS and chronic stress, but the role of tPVAT in these actions is also unknown. Therefore, the purpose of this study was to examine the effects of unpredictable chronic mild stress (UCMS) on the tPVAT regulation of aortic function and the preventative effect of AET. Lean (LZR) and obese (OZR) Zucker rats (16-17 weeks old) were exposed to 8 weeks of UCMS with and without treadmill exercise (AET). In LZR, UCMS impaired aortic endothelium-dependent dilatation (EDD) (assessed ex vivo by wire myography) and aortic stiffness (assessed by elastic modulus) with no change in OZR subject to UCMS. However, both LZR and OZR UCMS tPVAT impaired EDD compared to respective controls. LZR and OZR subject to UCMS had higher oxidative stress production, diminished adiponectin and impaired aortic nitric oxide levels. Divergently, UCMS induced greater inflammatory cytokine production in LZR UCMS tPVAT, but not in OZR UCMS tPVAT. AET prevented the tPVAT impairment of aortic relaxation with UCMS in LZR and OZR. Additionally, AET reduced aortic stiffness in both LZR and OZR. These beneficial effects on tPVAT regulation of the aorta are likely due to AET preservation of adiponectin, reduced oxidative stress and inflammation, and enhanced nitric oxide. UCMS impaired tPVAT-regulated aortic function in LZR, and augmented MetS-induced EDD in OZR. Conversely, AET in combination with UCMS largely preserved aortic function and the tPVAT environment, in both groups.
C1 [DeVallance, Evan R.; Branyan, Kayla W.; Olfert, I. Mark; Pistilli, Emidio E.; Bryner, Randall W.; Chantler, Paul D.] West Virginia Univ, Sch Med, Dept Exercise Physiol, Morgantown, WV 26506 USA.
   [Kelley, Eric E.] West Virginia Univ, Sch Med, Dept Physiol & Pharmacol, Morgantown, WV 26506 USA.
   [Frisbee, Jefferson C.] Univ Western Ontario, Schulich Sch Med & Dent, Dept Physiol & Pharmacol, London, ON, Canada.
   [Frisbee, Jefferson C.] Univ Western Ontario, Schulich Sch Med & Dent, Dept Med Biophys, London, ON, Canada.
   [Chantler, Paul D.] West Virginia Univ, Sch Med, Dept Neurosci, Morgantown, WV 26506 USA.
C3 West Virginia University; West Virginia University; Western University
   (University of Western Ontario); Western University (University of
   Western Ontario); West Virginia University
RP Chantler, PD (corresponding author), 64 Med Ctr Dr, Morgantown, WV 26505 USA.
EM pchantler@hsc.wvu.edu
OI Frisbee, Jefferson/0000-0003-2751-0599; Chantler,
   Paul/0000-0001-6960-9728
FU American Heart Association [IRG14330015]; AHA [14PRE20380386,
   19TPA34850089]; National Institutes of Health [R01DK124510-01]; National
   Institute of General Medical Sciences of the National Institutes of
   Health [U54GM104942, 5P20GM109098]; American Heart Association (AHA)
   [19TPA34850089, 14PRE20380386] Funding Source: American Heart
   Association (AHA)
FX This studywas supported by the American Heart Association grants
   IRG14330015, predoctoral fellowship AHA(14PRE20380386) and post-doctoral
   fellowshipAHA 19TPA34850089, National Institutes of Health
   R01DK124510-01 (E.E.K.), and National Institute of General Medical
   Sciences of the National Institutes of Health(U54GM104942 and
   5P20GM109098).
CR Abu-Amer Y, 1998, J BIOL CHEM, V273, P29417, DOI 10.1074/jbc.273.45.29417
   [Anonymous], 2015, National Survey on Drug Use and Health: Alternative Statistical Models to Predict Mental Illness
   Arnold N, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-06175-2
   Assersen KB, 2018, AM J PHYSIOL-RENAL, V315, pF1670, DOI 10.1152/ajprenal.00391.2018
   Baykan M, 2007, ENDOCRINE, V31, P300, DOI 10.1007/s12020-007-0033-8
   Branyan KW, 2018, MED SCI SPORT EXER, V50, P957, DOI 10.1249/MSS.0000000000001531
   Briones AM, 2012, HYPERTENSION, V59, P1069, DOI 10.1161/HYPERTENSIONAHA.111.190223
   Brooks S, 2018, EXP PHYSIOL, V103, P761, DOI 10.1113/EP086892
   Brooks SD, 2018, AM J PHYSIOL-HEART C, V314, pH1070, DOI 10.1152/ajpheart.00647.2017
   Brooks SD, 2015, AM J PHYSIOL-HEART C, V309, pH1846, DOI 10.1152/ajpheart.00691.2015
   Carey M, 2014, BRIT J GEN PRACT, V64, pE122, DOI 10.3399/bjgp14X677482
   Carlson SH, 2000, HYPERTENSION, V35, P403, DOI 10.1161/01.HYP.35.1.403
   Chantler P, 2018, BRAIN CIRC, V4, P43, DOI 10.4103/bc.bc_6_18
   Chatterjee TK, 2009, CIRC RES, V104, P541, DOI 10.1161/CIRCRESAHA.108.182998
   d'Audiffret AC, 2010, J APPL PHYSIOL, V108, P1041, DOI 10.1152/japplphysiol.01440.2009
   DeVallance E, 2015, INT J OBESITY, V39, P244, DOI 10.1038/ijo.2014.111
   DeVallance E, 2019, REDOX BIOL, V26, DOI 10.1016/j.redox.2019.101285
   DeVallance E, 2019, ANTIOXID REDOX SIGN, V31, P687, DOI 10.1089/ars.2018.7674
   DeVallance E, 2018, EXP PHYSIOL, V103, P590, DOI 10.1113/EP086818
   Donley DA, 2014, J APPL PHYSIOL, V116, P1396, DOI 10.1152/japplphysiol.00151.2014
   Ecobici M, 2017, ROM J INTERN MED, V55, P8, DOI 10.1515/rjim-2016-0043
   Esler M, 2006, HYPERTENSION, V48, P787, DOI 10.1161/01.HYP.0000242642.42177.49
   Förstermann U, 2017, CIRC RES, V120, P713, DOI 10.1161/CIRCRESAHA.116.309326
   Galougahi KK, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.113.000731
   Galvez B, 2006, ARTERIOSCL THROM VAS, V26, P1297, DOI 10.1161/01.ATV.0000220381.40739.dd
   Gil-Ortega M, 2015, TRENDS ENDOCRIN MET, V26, P367, DOI 10.1016/j.tem.2015.04.003
   Gleeson M, 2011, NAT REV IMMUNOL, V11, P607, DOI 10.1038/nri3041
   Golbidi S, 2015, AM J PHYSIOL-HEART C, V308, pH1476, DOI 10.1152/ajpheart.00859.2014
   Golbidi S, 2012, EXP DIABETES RES, DOI 10.1155/2012/941868
   Gollasch M, 2012, BRIT J PHARMACOL, V165, P633, DOI 10.1111/j.1476-5381.2011.01430.x
   Guzik TJ, 2007, J EXP MED, V204, P2449, DOI 10.1084/jem.20070657
   Guzik TJ, 2017, CARDIOVASC RES, V113, P1009, DOI 10.1093/cvr/cvx108
   Huggett RJ, 2004, HYPERTENSION, V44, P847, DOI 10.1161/01.HYP.0000147893.08533.d8
   Isenberg JS, 2009, NAT REV CANCER, V9, P182, DOI 10.1038/nrc2561
   James SL, 2018, LANCET, V392, P1789, DOI [10.1016/s0140-6736(18)32335-3, 10.1016/S0140-6736(18)32335-3]
   Javanmard Shaghayegh Haghjooy, 2012, Adv Biomed Res, V1, P69, DOI 10.4103/2277-9175.102973
   Jayatissa MN, 2010, STRESS, V13, P95, DOI 10.3109/10253890902951786
   Lambert EA, 2015, AM J PHYSIOL-HEART C, V309, pH244, DOI 10.1152/ajpheart.00096.2015
   Laurent S, 2003, STROKE, V34, P1203, DOI 10.1161/01.STR.0000065428.03209.64
   Laurent S, 2001, HYPERTENSION, V37, P1236, DOI 10.1161/01.HYP.37.5.1236
   Lee DY, 2013, J BIOL CHEM, V288, P28668, DOI 10.1074/jbc.M113.470971
   Liu SL, 2003, CIRCULATION, V108, P2400, DOI 10.1161/01.CIR.0000093188.53554.44
   Liu YN, 2015, EUR CYTOKINE NETW, V26, P15, DOI 10.1684/ecn.2015.0362
   Lizcano F, 2017, STEM CELLS INT, V2017, DOI 10.1155/2017/2767916
   Lu C, 2011, EUR J PHARMACOL, V656, P68, DOI 10.1016/j.ejphar.2011.01.023
   Mandler WK, 2017, NANOTOXICOLOGY, V11, P112, DOI 10.1080/17435390.2016.1277275
   Masaki T, 2004, HEPATOLOGY, V40, P177, DOI 10.1002/hep.20282
   Mattace-Raso FUS, 2006, CIRCULATION, V113, P657, DOI 10.1161/CIRCULATIONAHA.105.555235
   Mattsson C, 2003, ENDOCRINOLOGY, V144, P2997, DOI 10.1210/en.2002-221015
   Mikolajczyk TP, 2016, FASEB J, V30, P1987, DOI 10.1096/fj.201500088R
   Mineur YS, 2007, NEUROSCIENCE, V150, P251, DOI 10.1016/j.neuroscience.2007.09.045
   Mineur YS, 2006, BEHAV BRAIN RES, V175, P43, DOI 10.1016/j.bbr.2006.07.029
   Molofsky AB, 2013, J EXP MED, V210, P535, DOI 10.1084/jem.20121964
   MORGAN DA, 1995, HYPERTENSION, V25, P834, DOI 10.1161/01.HYP.25.4.834
   Mueller PJ, 2007, CLIN EXP PHARMACOL P, V34, P377, DOI 10.1111/j.1440-1681.2007.04590.x
   Nosalski R, 2017, BRIT J PHARMACOL, V174, P3496, DOI 10.1111/bph.13705
   Novelli EM, 2019, AM J PHYSIOL-LUNG C, V316, pL1150, DOI 10.1152/ajplung.00302.2018
   Oberleithner H, 2005, KIDNEY INT, V67, P1680, DOI 10.1111/j.1523-1755.2005.00263.x
   Oberleithner H, 2007, P NATL ACAD SCI USA, V104, P16281, DOI 10.1073/pnas.0707791104
   Paolo Bassareo Pier, 2014, Eur Endocrinol, V10, P161, DOI 10.17925/EE.2014.10.02.161
   Park SY, 2014, J PATHOL, V232, P87, DOI 10.1002/path.4286
   Pratt Laura A, 2014, NCHS Data Brief, P1
   Pu Q, 2003, HYPERTENSION, V42, P49, DOI 10.1161/01.HYP.0000078357.92682.EC
   Rajagopalan S, 2001, AM J CARDIOL, V88, P196, DOI 10.1016/S0002-9149(01)01623-X
   Rajsheker S, 2010, CURR OPIN PHARMACOL, V10, P191, DOI 10.1016/j.coph.2009.11.005
   Saxton SN, 2019, CARDIOVASC DRUG THER, V33, P245, DOI 10.1007/s10557-019-06862-4
   Seldenrijk A, 2011, BIOL PSYCHIAT, V69, P795, DOI 10.1016/j.biopsych.2010.12.034
   STYLIANOU E, 1992, J BIOL CHEM, V267, P15836
   Turner NA, 2007, CARDIOVASC RES, V76, P81, DOI 10.1016/j.cardiores.2007.06.003
   Van der Kooy K, 2007, INT J GERIATR PSYCH, V22, P613, DOI 10.1002/gps.1723
   Virdis A, 2002, HYPERTENSION, V40, P504, DOI 10.1161/01.HYP.0000034738.79310.06
   Wang ZV, 2008, HYPERTENSION, V51, P8, DOI 10.1161/HYPERTENSIONAHA.107.099424
   Whitworth Judith A, 2005, Vasc Health Risk Manag, V1, P291, DOI 10.2147/vhrm.2005.1.4.291
   Willner P, 1997, PSYCHOPHARMACOLOGY, V134, P319, DOI 10.1007/s002130050456
   Withers SB, 2011, ARTERIOSCL THROM VAS, V31, P908, DOI 10.1161/ATVBAHA.110.221705
   Wu CY, 2019, ADIPOCYTE, V8, P347, DOI 10.1080/21623945.2019.1690834
   Wu HT, 2013, APPL BIOCHEM BIOTECH, V169, P438, DOI 10.1007/s12010-012-9958-3
   Yalcin I, 2005, EUR J PHARMACOL, V514, P165, DOI 10.1016/j.ejphar.2005.03.029
   Yang XY, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00600
   Zemse SM, 2010, AM J PHYSIOL-HEART C, V299, pH1160, DOI 10.1152/ajpheart.00763.2009
   Zielonka J, 2014, J BIOL CHEM, V289, P16176, DOI 10.1074/jbc.M114.548693
NR 81
TC 12
Z9 13
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0958-0670
EI 1469-445X
J9 EXP PHYSIOL
JI Exp. Physiol.
PD JUN
PY 2021
VL 106
IS 6
BP 1343
EP 1358
DI 10.1113/EP089449
EA MAY 2021
PG 16
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA SK5YT
UT WOS:000650130000001
PM 33913209
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Peña, E
   Powell, TR
   Arenas, C
   Cardoner, N
   Rebasa, P
   Luna, A
   Caixàs, A
   Rosa, A
AF Pena, Elionora
   Powell, Timothy R.
   Arenas, Concepcion
   Cardoner, Narcis
   Rebasa, Pere
   Luna, Alexis
   Caixas, Assumpta
   Rosa, Araceli
TI Longitudinal changes in telomere length in a cohort of obese patients
   submitted to bariatric surgery: a 2-year follow-up
SO SURGERY FOR OBESITY AND RELATED DISEASES
LA English
DT Article
DE Relative telomere length; Obesity; Bariatric surgery; Weight loss; T2D;
   Metabolic syndrome; Follow-up
ID BODY-MASS INDEX; WEIGHT-LOSS; DEPRESSION; INTERVENTION; ASSOCIATION;
   STRESS; ADULTS
AB Background: Telomere length (TL) is one biomarker of cell aging used to explore the effects of the environment on age-related pathologies. Obesity and high body mass index have been identified as a risk factors for shortened TL.
   Objective: To evaluate TL in different subtypes of obese patients, and to examine changes in TL in relation to weight loss after bariatric surgery.
   Setting: University Hospital in Spain.
   Methods: A cohort of 94 patients submitted to bariatric surgery were followed-up during 24 months (t(24)(m): lost to follow-up = 0%). All patients were evaluated before surgery (t(0)) and during the postoperative period (t(6m), t(12)(m), and t(24)(m)) for body mass index and metabolic variables. We assessed TL at each timepoint using quantitative polymerase chain reactions and the telomere sequence to single-copy gene sequence ratio method.
   Results: Patients with class III obesity showed significantly shorter TL at baseline than those patients with class II obesity (P = .027). No differences in TL were found between patients with or without This type 2 diabetes or metabolic syndrome. Longitudinal analysis did not show an effect of time, type of surgery, age, or sex on TL. However, a generalized estimating equation model showed that TL was shorter amongst class III obesity patients across the time course (P = .008). Comparison between patients with obesity class II and class III showed differences in TL at t(6m), (adjusted P = .024), whereby class II patients had longer TL. However, no difference was observed at the other evaluated times.
   Conclusion: Obesity severity may have negative effects on TL independently of type 2 diabetes or metabolic syndrome. Although TL is significantly longer in class II obesity patients relative to class III 6 months after bariatric surgery. This difference is not apparent after 24 months. (C) 2020 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.
C1 [Pena, Elionora; Rosa, Araceli] Univ Barcelona, Fac Biol, Seccio Zool & Antropol Biol, Dept Biol Evolut Ecol & Ciencies Ambientals, Diagonal 643, Barcelona 08028, Spain.
   [Pena, Elionora; Rosa, Araceli] Univ Barcelona, Inst Biomed, Barcelona, Spain.
   [Powell, Timothy R.] Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London, England.
   [Powell, Timothy R.] Cornell Univ, Div Infect Dis, Weill Cornell Med, New York, NY USA.
   [Arenas, Concepcion] Univ Barcelona, Fac Biol, Dept Genet Microbiol & Estadist, Seccio Estadist, Barcelona, Spain.
   [Cardoner, Narcis; Rebasa, Pere; Luna, Alexis; Caixas, Assumpta] Inst Invest & Innovacio, Parc Tauli, Sabadell, Spain.
   [Cardoner, Narcis] Corp Sanitaria, Mental Hlth Dept, Parc Tauli, Sabadell, Spain.
   [Cardoner, Narcis] Hosp Univ, Dept Mental Hlth, Depress & Anxiety Program, Parc Tauli Sabadell, Barcelona, Spain.
   [Cardoner, Narcis] Univ Autonoma Barcelona, Dept Psychiat & Legal Med, Barcelona, Spain.
   [Cardoner, Narcis; Rosa, Araceli] Inst Salud Carlos III, Ctr Biomed Res Network Mental Hlth, Barcelona, Spain.
   [Rebasa, Pere; Luna, Alexis] Hosp Univ, Esofagogastr Surg Sect, Surg Dept, Parc Tauli, Sabadell, Spain.
   [Caixas, Assumpta] Univ Autonoma Barcelona, Endocrinol & Nutr Dept, Hosp Univ, Med Dept, Parc Tauli, Sabadell, Spain.
C3 University of Barcelona; University of Barcelona; University of London;
   King's College London; Cornell University; Weill Cornell Medicine;
   University of Barcelona; Autonomous University of Barcelona; Parc Tauli
   Hospital Universitari; University of Sevilla; Autonomous University of
   Barcelona; Instituto de Salud Carlos III; University of Sevilla;
   Autonomous University of Barcelona; University of Sevilla
RP Rosa, A (corresponding author), Univ Barcelona, Fac Biol, Seccio Zool & Antropol Biol, Dept Biol Evolut Ecol & Ciencies Ambientals, Diagonal 643, Barcelona 08028, Spain.; Caixàs, A (corresponding author), Hosp Univ, Endocrinol & Nutr Dept, Parc Tauli,C Parc Tauli 1, Sabadell 08208, Spain.
EM acaixas@tauli.cat; araceli.rosa@ub.edu
RI Rebasa, Pere/HTT-2204-2023; Cardoner, Narcis/AAD-5449-2022; Peña,
   Elionora/ABH-7588-2020; Rosa, Araceli/Q-2099-2016; Arenas,
   Concepcion/H-5579-2015
OI Powell, Timothy/0000-0001-9891-4895; Caixas,
   Assumpta/0000-0001-8472-9189; Cardoner, Narcis/0000-0001-9633-0888;
   Rosa, Araceli/0000-0001-6935-3785; Rebasa, Pere/0000-0003-0580-1985;
   Pena, Elionora/0000-0001-5003-5453; Arenas,
   Concepcion/0000-0002-6489-4934
FU Fundaci~o Parc Tauli [CIR2016/034]; Comissionat per a Universitats i
   Recerca of the Generalitat [2017 SGR1577]; Fundacio Montcelimar and
   Universitat de Barcelona; Medical Research Council Skills Development
   Fellowship [MR/N014863/1]; MRC [MR/N014863/1] Funding Source: UKRI
FX This study was supported by Fundaci~o Parc Tauli (Grant CIR2016/034),
   the Comissionat per a Universitats i Recerca of the Generalitat (2017
   SGR1577). E. Pena was funded by the fellowship for formative stays grant
   by the Fundacio Montcelimar and Universitat de Barcelona. T. Powell is
   funded by a Medical Research Council Skills Development Fellowship
   (MR/N014863/1).
CR [Anonymous], 2020, NUTR BOD MASS IND
   Blackburn EH, 2001, CELL, V106, P661, DOI 10.1016/S0092-8674(01)00492-5
   Carulli L, 2016, MOL GENET METAB, V118, P138, DOI 10.1016/j.ymgme.2016.04.003
   Cawthon RM, 2009, NUCLEIC ACIDS RES, V37, DOI 10.1093/nar/gkn1027
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Daubenmier J, 2012, PSYCHONEUROENDOCRINO, V37, P917, DOI 10.1016/j.psyneuen.2011.10.008
   de Zwaan M, 2011, J AFFECT DISORDERS, V133, P61, DOI 10.1016/j.jad.2011.03.025
   Dershem R, 2017, INT J OBESITY, V41, P1718, DOI 10.1038/ijo.2017.156
   DI LEONARDO A, 1994, GENE DEV, V8, P2540, DOI 10.1101/gad.8.21.2540
   Epel E, 2012, CANCER PREV RES, V5, P1163, DOI 10.1158/1940-6207.CAPR-12-0370
   Farzaneh-Far R, 2010, JAMA-J AM MED ASSOC, V303, P250, DOI 10.1001/jama.2009.2008
   Fingeret M, 2018, NUTR METAB CARDIOVAS, V28, P1036, DOI 10.1016/j.numecd.2018.06.011
   Formichi C, 2014, OBES SURG, V24, P2089, DOI 10.1007/s11695-014-1300-4
   Fried M, 2014, Rozhl Chir, V93, P366
   García-Calzón S, 2014, INT J OBESITY, V38, P177, DOI 10.1038/ijo.2013.68
   Gielen M, 2018, AM J CLIN NUTR, V108, P453, DOI 10.1093/ajcn/nqy107
   Horwich TB, 2018, PROG CARDIOVASC DIS, V61, P151, DOI 10.1016/j.pcad.2018.05.005
   Huffman DM, 2009, BBA-GEN SUBJECTS, V1790, P1117, DOI 10.1016/j.bbagen.2009.01.008
   Kim SM, 2009, CANCER EPIDEM BIOMAR, V18, P816, DOI 10.1158/1055-9965.EPI-08-0935
   Laimer M, 2016, INT J OBESITY, V40, P773, DOI 10.1038/ijo.2015.238
   Monroy-Jaramillo N, 2018, WORLD J BIOL PSYCHIA, V19, pS2, DOI 10.1080/15622975.2016.1273550
   Müezzinler A, 2014, OBES REV, V15, P192, DOI 10.1111/obr.12126
   Ouchi N, 2011, NAT REV IMMUNOL, V11, P85, DOI 10.1038/nri2921
   Peña E, 2020, SURG OBES RELAT DIS, V16, P581, DOI 10.1016/j.soard.2019.12.002
   Poli G, 2004, CURR MED CHEM, V11, P1163, DOI 10.2174/0929867043365323
   Powell TR, 2018, NEUROPSYCHOPHARMACOL, V43, P445, DOI 10.1038/npp.2017.125
   Reichert S, 2017, BIOL LETTERS, V13, DOI 10.1098/rsbl.2017.0463
   Schutte NS, 2015, DEPRESS ANXIETY, V32, P229, DOI 10.1002/da.22351
   Sun XL, 2017, GASTROENTEROL REP, V5, P266, DOI 10.1093/gastro/gox033
   Vincent J, 2017, J AFFECT DISORDERS, V213, P16, DOI 10.1016/j.jad.2017.01.031
   Wolfe BM, 2016, CIRC RES, V118, P1844, DOI 10.1161/CIRCRESAHA.116.307591
   World Med Assoc, 2013, JAMA-J AM MED ASSOC, V310, P2191, DOI 10.1001/jama.2013.281053
NR 32
TC 2
Z9 2
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1550-7289
EI 1878-7533
J9 SURG OBES RELAT DIS
JI Surg. Obes. Relat. Dis.
PD NOV
PY 2020
VL 16
IS 11
BP 1794
EP 1801
DI 10.1016/j.soard.2020.06.027
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA OH7SO
UT WOS:000582794000027
PM 32741725
DA 2025-06-11
ER

PT J
AU Akkurt, H
   Karapolat, HU
   Kirazli, Y
   Kose, T
AF Akkurt, Halil
   Karapolat, Hale U.
   Kirazli, Yesim
   Kose, Timur
TI The effects of upper extremity aerobic exercise in patients with spinal
   cord injury: a randomized controlled study
SO EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
LA English
DT Article
DE Spinal cord injuries; Exercise; Ergometry
ID QUALITY-OF-LIFE; TRAINING-PROGRAMS; BODY-COMPOSITION; ARM CRANKING;
   INDIVIDUALS; PERFORMANCE; PARTICIPATION; METAANALYSIS; ERGOMETRY;
   CAPACITY
AB BACKGROUND: Immobility and secondary complications, including cardiopulmonary disease, pressure ulcers, and pain, occur in patients with spinal cord injury (SCI). These patients also have difficulty coping with the strain of daily activities. Thus, it is important for SCI patients to engage in aerobic exercise in order to be able to cope adequately with the strain of activities and SCI-related complications.
   AIM: The aim of this study was to investigate the effects of arm aerobic exercise on the parameters of cardiopulmonary function, quality of life, degree of disability, psychological state, and metabolic syndrome.
   DESIGN: This study was a single blind, randomized, controlled trial.
   SETTING: This study was conducted in a university hospital.
   POPULATION: SCI patients were randomly assigned to an intervention group (N.= 17) or a control group (N.= 16). Arm ergometer exercises (three days/week; 1.5 hours/week 50-70% pVO(2)) and general exercises (two sessions/day; 5 days/week), were assigned to the intervention group for 12 weeks. The control group was assigned general exercises only during this trial.
   METHODS: Before the rehabilitation (Week 0), after six weeks, and after the rehabilitation (Week 12), all patients were evaluated for functional status (maximal oxygen uptake [ pVO(2)], power output [ PO], and Functional Independence Measurement), pulmonary function (FEV1%, FVC%, FEV1/FVC%), quality of life (World Health Organization Measure of Quality of Life, short form, Turkish version), metabolic syndrome parameters (triglycerides, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, fasting blood sugar, waist circumference, and systolic and diastolic blood pressure), degree of disability (Craig Handicap Assessment and Reporting Technique, short form), and psychological status (Center for Epidemiologic Studies Depression Scale and Hospital Anxiety and Depression Scale).
   RESULTS: At the end of the study, increases of 39.6% and 45.4% in the pVO(2) and PO levels, respectively, were found. Additionally, no statistically significant difference was found in the intervention group after the rehabilitation compared to the levels before rehabilitation (P< 0.05). However, no statistically significant differences in functional status, quality of life, psychological state, level of disability, or metabolic syndrome parameters were found in the intervention group (P> 0.05). The control group, on the other hand, showed no clinically significant differences in any of the parameters (P> 0.05).
   CONCLUSIONS: Short-term arm aerobic exercise performed by patients with SCI improves their exercise capacities. These patients require longer rehabilitation programs to receive more benefits from aerobic exercise training.
   CLINICAL REHABILITATION IMPACT: Adding arm cranking exercise training to the rehabilitation program of patients with spinal cord injury demonstrated improved exercise capacity; however, further studies are needed to assess the effects of exercise training on other health issues.
C1 [Akkurt, Halil; Karapolat, Hale U.; Kirazli, Yesim] Ege Univ, Dept Phys Med & Rehabil, Fac Med, TR-35100 Izmir, Turkey.
   [Kose, Timur] Ege Univ, Fac Med, Dept Biostat & Med Informat, Izmir, Turkey.
C3 Ege University; Ege University
RP Karapolat, HU (corresponding author), Ege Univ, Dept Phys Med & Rehabil, Fac Med, TR-35100 Izmir, Turkey.
EM hale.karapolat@ege.edu.tr
RI Uzumcugil, Hale/LZF-2747-2025; Kirazli, Yesim/LZF-1008-2025; KOSE,
   Timur/ABH-3197-2021
OI KOSE, Timur/0000-0002-5238-9738
CR [Anonymous], SPINAL CORD INJURY R
   Aydemir O., 1997, Turk Psikiyatri Dergisi, V8, P280
   Brurok B, 2011, AM J PHYS MED REHAB, V90, P407, DOI 10.1097/PHM.0b013e31820f960f
   Carlson KF, 2009, J SPINAL CORD MED, V32, P361, DOI 10.1080/10790268.2009.11754465
   Cowan RE, 2010, DISABIL REHABIL, V32, P2228, DOI 10.3109/09638288.2010.491579
   Dallmeijer AJ, 1999, MED SCI SPORT EXER, V31, P1330, DOI 10.1097/00005768-199909000-00015
   de Groot PCE, 2003, SPINAL CORD, V41, P673, DOI 10.1038/sj.sc.3101534
   Devillard X., 2007, ANN READAPT MED PHYS, V50, P490, DOI [DOI 10.1016/j.annrmp.2007.04.013, DOI 10.1016/j.annrmp.2007.04.014, 10.1016/j.annrmp.2007.04.013]
   Dijkers M, 1997, SPINAL CORD, V35, P829, DOI 10.1038/sj.sc.3100571
   Dijkers MPJM, 2002, SPINAL CORD, V40, P351, DOI 10.1038/sj.sc.3101310
   Ditor DS, 2003, SPINAL CORD, V41, P446, DOI 10.1038/sj.sc.3101487
   Effing TW, 2006, SPINAL CORD, V44, P287, DOI 10.1038/sj.sc.3101841
   El-Sayed MS, 2005, SPINAL CORD, V43, P299, DOI 10.1038/sj.sc.3101698
   Elliott TR, 2004, REHABIL PSYCHOL, V49, P134, DOI 10.1037/0090-5550.49.2.134
   Eng J, 2008, SPINAL CORD INJURY R, V2, P4
   Eser S. Y., 1999, Journal of Psychiatry, Psychology, and Psychoparmacology, V7, P5
   Vázquez RG, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/168757
   Gómara-Toldrà N, 2014, J SPINAL CORD MED, V37, P371, DOI 10.1179/2045772314Y.0000000194
   Gorgey AS, 2015, J SPINAL CORD MED, V38, P23, DOI 10.1179/2045772314Y.0000000244
   Hicks AL, 2011, SPINAL CORD, V49, P1103, DOI 10.1038/sc.2011.62
   Hicks AL, 2003, SPINAL CORD, V41, P34, DOI 10.1038/sj.sc.3101389
   HOLDEN MK, 1984, PHYS THER, V64, P35, DOI 10.1093/ptj/64.1.35
   Jacobs PL, 2004, SPORTS MED, V34, P727, DOI 10.2165/00007256-200434110-00003
   Kirshblum SC, 2011, J SPINAL CORD MED, V34, P547, DOI 10.1179/107902611X13186000420242
   Kloosterman MGM, 2009, SPINAL CORD, V47, P196, DOI 10.1038/sc.2008.113
   Knechtle B, 2003, EUR J APPL PHYSIOL, V90, P614, DOI 10.1007/s00421-003-0920-5
   Küçükdeveci AA, 2001, CLIN REHABIL, V15, P311, DOI 10.1191/026921501676877265
   Moro DL, 2005, ARCH PHYS MED REHAB, V86, P1582, DOI 10.1016/j.apmr.2005.03.018
   Pescatello L.S., 2013, American College of Sports Medicine ACSM'S Guidelines for Exercise Testing and Prescription, V9th
   Phillips AA, 2011, SPINAL CORD, V49, P702, DOI 10.1038/sc.2010.193
   Post MWM, 2012, SPINAL CORD, V50, P382, DOI 10.1038/sc.2011.182
   RADLOFF L S, 1986, Clinical Gerontologist, V5, P119
   Spooren AIF, 2009, J REHABIL MED, V41, P497, DOI 10.2340/16501977-0387
   Sutbeyaz ST, 2005, INT J REHABIL RES, V28, P273, DOI 10.1097/00004356-200509000-00012
   Tamplin J, 2014, SPINAL CORD, V52, P175, DOI 10.1038/sc.2013.162
   Warms CA, 2004, AM J HEALTH PROMOT, V18, P288, DOI 10.4278/0890-1171-18.4.288
   Zwinkels M, 2014, CLIN REHABIL, V28, P847, DOI 10.1177/0269215514525181
NR 37
TC 47
Z9 52
U1 4
U2 58
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 1973-9087
EI 1973-9095
J9 EUR J PHYS REHAB MED
JI Eur. J. Phys. Rehabil. Med.
PD APR
PY 2017
VL 53
IS 2
BP 219
EP 227
DI 10.23736/S1973-9087.16.03804-1
PG 9
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rehabilitation
GA EZ8DF
UT WOS:000404953900009
PM 27824234
DA 2025-06-11
ER

PT J
AU Kario, K
   McEwen, BS
   Pickering, TG
AF Kario, K
   McEwen, BS
   Pickering, TG
TI Disasters and the heart: A review of the effects of earthquake-induced
   stress on cardiovascular disease
SO HYPERTENSION RESEARCH
LA English
DT Review
DE stress; hypertension; cardiovascular disease; risk factor
ID HANSHIN-AWAJI EARTHQUAKE; ACUTE MYOCARDIAL-INFARCTION; ELDERLY
   HYPERTENSIVE PATIENTS; WHITE-COAT HYPERTENSION; AMBULATORY
   BLOOD-PRESSURE; FACTOR-VII HYPERACTIVITY; ENDOTHELIAL-CELL DAMAGE;
   MEDICAL-SCHOOL COHORT; ACTIVATED FACTOR-VII; ACUTE RISK-FACTORS
AB There is growing evidence that stress contributes to cardiovascular disease. Chronic stress contributes to the atherosclerotic process through increased allostatic load, which is mediated by the neuroendocrine and immune systems (sympathetic nervous system and hypothalamus-pituitary adrenal axis) and related chronic risk factors (insulin resistance syndrome, hypertension, diabetes, and hyperlipidemia). In addition, acute stress can trigger cardiovascular events predominantly through sympathetic nervous activation and potentiation of acute risk factors (blood pressure increase, endothelial cell dysfunction, increased blood viscosity, and platelet and hemostatic activation). Earthquakes provide a good example of naturally occurring acute and chronic stress, and in this review we focus mainly on the effects of the Hanshin-Awaji earthquake on the cardiovascular system. The Hanshin-Awaji earthquake resulted in a 3-fold increase of myocardial infarctions in people living close to the epicenter, particularly in women, with most of the increase occurring in nighttime-onset events. There was also a near doubling in the frequency of strokes. These effects may be mediated by changes in hemostatic factors, as demonstrated by an increase of D-dimer, von Willebrand factor, and tissue-type plasminogen activator (tPA) antigen. Blood pressure also increased after the earthquake, and was prolonged for several weeks in patients with microalbuminuria.
C1 Jichi Med Sch, Dept Cardiol, Minami Kawachi, Tochigi 3290498, Japan.
   Mt Sinai Sch Med, Behav & Integrat Cardiol Program, Zena & Michael A Wiener Cardiovasc Ctr, New York, NY USA.
   Harold & Margaret Milliken Hatch Lab Neuroendocri, New York, NY USA.
C3 Jichi Medical University; Icahn School of Medicine at Mount Sinai
RP Jichi Med Sch, Dept Cardiol, 3311-1 Yakushiji, Minami Kawachi, Tochigi 3290498, Japan.
EM kkario@jichi.ac.jp
RI McEwen, Bruce/Z-1630-2019
FU NHLBI NIH HHS [P01 HL047540, HL-47540] Funding Source: Medline
CR ALLEN MT, 1995, BIOL PSYCHOL, V41, P1, DOI 10.1016/0301-0511(95)05123-R
   Arita M, 1996, Hypertens Res, V19, P195, DOI 10.1291/hypres.19.195
   Barefoot JC, 1996, CIRCULATION, V93, P1976, DOI 10.1161/01.CIR.93.11.1976
   BENHORIN J, 1993, CIRCULATION, V87, P808, DOI 10.1161/01.CIR.87.3.808
   BERG K, 1983, PROG MED GENET, V5, P35
   Brunner E, 1996, LANCET, V347, P1008, DOI 10.1016/S0140-6736(96)90147-6
   Camacho A, 2000, PSYCHOSOM MED, V62, P326, DOI 10.1097/00006842-200005000-00006
   CARNEY RM, 1991, CORONARY ARTERY DIS, V2, P61
   Cernak I, 2000, MAGNESIUM RES, V13, P29
   Davidson K, 2000, ARCH INTERN MED, V160, P1495, DOI 10.1001/archinte.160.10.1495
   De Cristofaro R, 2002, THROMB HAEMOSTASIS, V87, P58
   DIEZROUX AV, 1995, AM J EPIDEMIOL, V141, P960, DOI 10.1093/oxfordjournals.aje.a117363
   DOBSON AJ, 1991, MED J AUSTRALIA, V155, P757, DOI 10.5694/j.1326-5377.1991.tb94029.x
   Ebata H, 1995, Hypertens Res, V18, P125, DOI 10.1291/hypres.18.125
   Everson SA, 1997, BRIT MED J, V314, P553, DOI 10.1136/bmj.314.7080.553
   FOLSOM AR, 1994, STROKE, V25, P66, DOI 10.1161/01.STR.25.1.66
   Frimerman A, 1997, AM J CARDIOL, V79, P72, DOI 10.1016/S0002-9149(96)00680-7
   GERIN W, 1995, J HYPERTENS, V13, P603, DOI 10.1097/00004872-199506000-00005
   Gullette ECD, 1997, JAMA-J AM MED ASSOC, V277, P1521, DOI 10.1001/jama.277.19.1521
   IKEDA Y, 1991, J CLIN INVEST, V87, P1234, DOI 10.1172/JCI115124
   Inui A, 1998, ARCH INTERN MED, V158, P274, DOI 10.1001/archinte.158.3.274
   JAMES GD, 1993, PSYCHOSOM MED, V55, P55, DOI 10.1097/00006842-199301000-00010
   JAYO JM, 1993, INT J OBESITY, V17, P597
   Jonas BS, 2000, PSYCHOSOM MED, V62, P463, DOI 10.1097/00006842-200007000-00001
   KAIRO K, 1995, ATHEROSCLEROSIS, V116, P211
   Kamarck TW, 1997, CIRCULATION, V96, P3842
   Kapiotis S, 1997, CIRCULATION, V96, P19
   KARIO K, 1995, ARTERIOSCL THROM VAS, V15, P1114, DOI 10.1161/01.ATV.15.8.1114
   Kario K, 1997, J AM GERIATR SOC, V45, P610, DOI 10.1111/j.1532-5415.1997.tb03096.x
   Kario K, 1996, ARTERIOSCL THROM VAS, V16, P269, DOI 10.1161/01.ATV.16.2.269
   KARIO K, 1995, LANCET, V345, P1365, DOI 10.1016/S0140-6736(95)92561-9
   Kario K, 1999, HYPERTENS RES-CLIN E, V22, P95, DOI 10.1291/hypres.22.95
   Kario K, 1996, ARTERIOSCL THROM VAS, V16, P734, DOI 10.1161/01.ATV.16.6.734
   Kario K, 1997, J AM COLL CARDIOL, V29, P926, DOI 10.1016/S0735-1097(97)00002-8
   KARIO K, 1991, THROMB RES, V62, P501, DOI 10.1016/0049-3848(91)90023-P
   Kario K, 1998, HYPERTENSION, V31, P77, DOI 10.1161/01.HYP.31.1.77
   Kario K, 1999, HYPERTENSION, V34, P685, DOI 10.1161/01.HYP.34.4.685
   KARIO K, 1993, ATHEROSCLEROSIS, V103, P131, DOI 10.1016/0021-9150(93)90256-T
   Kario K, 1998, AM J HYPERTENS, V11, P1138
   Kario K, 1998, J AM COLL CARDIOL, V32, P553
   KARIO K, 1995, THROMB HAEMOSTASIS, V74, P1207
   Kario K, 1997, HYPERTENSION, V30, P1504, DOI 10.1161/01.HYP.30.6.1504
   Kario K, 1996, HYPERTENSION, V27, P130, DOI 10.1161/01.HYP.27.1.130
   Kario K, 2002, HYPERTENS RES, V25, P499, DOI 10.1291/hypres.25.499
   Kario K, 2002, HYPERTENS RES, V25, P543
   Kario K, 1998, J AM GERIATR SOC, V46, P537, DOI 10.1111/j.1532-5415.1998.tb02485.x
   Kario K, 2001, AM J MED, V111, P379, DOI 10.1016/S0002-9343(01)00832-4
   KARIO K, 1994, ARTERIOSCLER THROMB, V14, P265, DOI 10.1161/01.ATV.14.2.265
   Kario K, 1996, LANCET, V347, P626, DOI 10.1016/S0140-6736(96)91332-X
   Kario K, 2001, J AM COLL CARDIOL, V37, P871, DOI 10.1016/S0735-1097(00)01172-4
   Kario K, 2001, HYPERTENSION, V38, P852, DOI 10.1161/hy1001.092640
   KARIO K, 1992, THROMB RES, V66, P489, DOI 10.1016/0049-3848(92)90303-R
   KARIO K, 1991, THROMB HAEMOSTASIS, V65, P25
   Kario K, 1999, LANCET, V353, P1800, DOI 10.1016/S0140-6736(05)75903-1
   Kario K, 2000, HYPERTENSION, V35, P787, DOI 10.1161/01.HYP.35.3.787
   Kario K, 1999, LANCET, V354, P339, DOI 10.1016/S0140-6736(05)75247-8
   Kario K, 1996, ARTERIOSCL THROM VAS, V16, P455, DOI 10.1161/01.ATV.16.3.455
   Kawachi I, 1996, CIRCULATION, V94, P2090, DOI 10.1161/01.CIR.94.9.2090
   KAWACHI I, 1994, CIRCULATION, V90, P2225, DOI 10.1161/01.CIR.90.5.2225
   KIRSCHBAUM C, 1995, PSYCHOSOM MED, V57, P468, DOI 10.1097/00006842-199509000-00009
   Kloner RA, 1997, J AM COLL CARDIOL, V30, P1174, DOI 10.1016/S0735-1097(97)00281-7
   KUWAJIMA I, 1995, AM J HYPERTENS, V8, P29, DOI 10.1016/0895-7061(94)00154-4
   Leor J, 1996, NEW ENGL J MED, V334, P413, DOI 10.1056/NEJM199602153340701
   Lewthwaite J, 2002, CIRCULATION, V106, P196, DOI 10.1161/01.CIR.0000021121.26290.2C
   Light KC, 1999, HYPERTENSION, V33, P1458, DOI 10.1161/01.HYP.33.6.1458
   Lynch J, 1997, CIRCULATION, V96, P302
   Matthews KA, 1998, PSYCHOSOM MED, V60, P633, DOI 10.1097/00006842-199809000-00021
   MCCARTY R, 1985, J AUTONOM NERV SYST, V12, P15, DOI 10.1016/0165-1838(85)90037-2
   MCEWEN BS, 1993, ARCH INTERN MED, V153, P2093, DOI 10.1001/archinte.153.18.2093
   MCEWEN BS, 1992, PROG BRAIN RES, V93, P365
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   MELLMAN TA, 1995, AM J PSYCHIAT, V152, P1659
   Minami J, 1997, AM J HYPERTENS, V10, P222, DOI 10.1016/S0895-7061(96)00328-7
   Mitsumoto A, 2002, FREE RADICAL BIO MED, V32, P22, DOI 10.1016/S0891-5849(01)00755-9
   Moller P, 1996, CHEM-BIOL INTERACT, V102, P17, DOI 10.1016/0009-2797(96)03729-5
   Moyer A E, 1994, Obes Res, V2, P255
   MULLER JE, 1994, J AM COLL CARDIOL, V23, P809, DOI 10.1016/0735-1097(94)90772-2
   MULLER JE, 1989, CIRCULATION, V79, P733, DOI 10.1161/01.CIR.79.4.733
   MUNCK A, 1984, ENDOCR REV, V5, P25, DOI 10.1210/edrv-5-1-25
   NAGO N, 1995, AM J EPIDEMIOL, V141, P815, DOI 10.1093/oxfordjournals.aje.a117516
   Narita I, 2001, HYPERTENS RES, V24, P111, DOI 10.1291/hypres.24.111
   PANZA JA, 1991, NEW ENGL J MED, V325, P986, DOI 10.1056/NEJM199110033251402
   Pickering T, 1999, ANN NY ACAD SCI, V896, P262, DOI 10.1111/j.1749-6632.1999.tb08121.x
   PICKERING TG, 1988, JAMA-J AM MED ASSOC, V259, P225, DOI 10.1001/jama.259.2.225
   Pickering TG, 1996, J HYPERTENS, V14, pS179
   PICKERING TG, 1994, AM J HYPERTENS, V7, P844, DOI 10.1093/ajh/7.9.844
   PICKERING TG, 1994, AM J HYPERTENS, V7, P848, DOI 10.1093/ajh/7.9.848
   PLOMIN R, 1990, SCIENCE, V248, P183, DOI 10.1126/science.2183351
   Raikkonen K, 1996, ARTERIOSCL THROM VAS, V16, P363, DOI 10.1161/01.ATV.16.3.363
   RIDKER PM, 1990, CIRCULATION, V82, P897, DOI 10.1161/01.CIR.82.3.897
   RIDKER PM, 1993, LANCET, V341, P1165, DOI 10.1016/0140-6736(93)90998-V
   RIDKER PM, 1994, LANCET, V343, P940, DOI 10.1016/S0140-6736(94)90064-7
   Rosenfeld BA, 1998, ANESTH ANALG, V86, P640, DOI 10.1097/00000539-199803000-00038
   Rozanski A, 1999, CIRCULATION, V99, P2192, DOI 10.1161/01.CIR.99.16.2192
   SADEH A, 1995, SLEEP, V18, P288, DOI 10.1093/sleep/18.4.288
   Saito K, 1997, AM J HYPERTENS, V10, P217, DOI 10.1016/S0895-7061(96)00351-2
   Sayer JW, 1998, J AM COLL CARDIOL, V32, P1962, DOI 10.1016/S0735-1097(98)00481-1
   Schnall PL, 1998, PSYCHOSOM MED, V60, P697, DOI 10.1097/00006842-199811000-00007
   Skantze HB, 1998, ATHEROSCLEROSIS, V136, P153, DOI 10.1016/S0021-9150(97)00202-5
   SOMERS VK, 1993, NEW ENGL J MED, V328, P303, DOI 10.1056/NEJM199302043280502
   Sterling P., 1988, Handbook of life stress, cognition, and health, P629
   Suarez E C., 1991, Journal of Cardiopulmonary Rehabilitation, V11, P169
   Suzuki S, 1997, AM HEART J, V134, P974, DOI 10.1016/S0002-8703(97)80023-3
   SUZUKI S, 1995, LANCET, V345, P981, DOI 10.1016/S0140-6736(95)90727-0
   Takakuwa H, 2001, HYPERTENS RES, V24, P195, DOI 10.1291/hypres.24.195
   TREVISAN M, 1986, ARTERIOSCLEROSIS, V6, P491, DOI 10.1161/01.ATV.6.5.491
   TRICHOPOULOS D, 1983, LANCET, V1, P441
   Wamala SP, 1999, ARTERIOSCL THROM VAS, V19, P485, DOI 10.1161/01.ATV.19.3.485
   Wilkinson CW, 1997, NEUROENDOCRINOLOGY, V65, P79, DOI 10.1159/000127167
NR 109
TC 160
Z9 181
U1 0
U2 19
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD MAY
PY 2003
VL 26
IS 5
BP 355
EP 367
DI 10.1291/hypres.26.355
PG 13
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA 698YJ
UT WOS:000184027600002
PM 12887126
OA Bronze
DA 2025-06-11
ER

PT J
AU Alvarez-Monell, A
   Subias-Gusils, A
   Mariné-Casadó, R
   Belda, X
   Gagliano, H
   Pozo, OJ
   Boqué, N
   Caimari, A
   Armario, A
   Solanas, M
   Escorihuela, RM
AF Alvarez-Monell, Adam
   Subias-Gusils, Alex
   Marine-Casado, Roger
   Belda, Xavier
   Gagliano, Humberto
   Pozo, Oscar J.
   Boque, Noemi
   Caimari, Antoni
   Armario, Antonio
   Solanas, Montserrat
   Escorihuela, Rosa M.
TI Restricted cafeteria feeding and treadmill exercise improved body
   composition, metabolic profile and exploratory behavior in obese male
   rats
SO SCIENTIFIC REPORTS
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; CORTICOTROPIN-RELEASING FACTOR; HIGH-FAT; HPA
   AXIS; INSULIN-RESISTANCE; LOCOMOTOR-ACTIVITY; PHYSICAL-ACTIVITY; DIET;
   STRESS; CORTICOSTERONE
AB The aim of this study was to evaluate, in male Long-Evans rats, whether a restricted-cafeteria diet (CAFR), based on a 30% calorie restriction vs continuous ad libitum cafeteria (CAF) fed animals, administered alone or in combination with moderate treadmill exercise (12 m/min, 35 min, 5 days/week for 8 weeks), was able to ameliorate obesity and the associated risk factors induced by CAF feeding for 18 weeks and to examine the changes in circadian locomotor activity, hypothalamic-pituitary-adrenal (HPA) axis functionality, and stress response elicited by this dietary pattern. In addition to the expected increase in body weight and adiposity, and the development of metabolic dysregulations compatible with Metabolic Syndrome, CAF intake resulted in a sedentary profile assessed by the home-cage activity test, reduced baseline HPA axis activity through decreased corticosterone levels, and boosted exploratory behavior. Both CAFR alone and in combination with exercise reduced abdominal adiposity and hypercholesterolemia compared to CAF. Exercise increased baseline locomotor activity in the home-cage in all dietary groups, boosted exploratory behavior in STD and CAF, partially decreased anxiety-like behavior in CAF and CAFR, but did not affect HPA axis-related parameters.
C1 [Alvarez-Monell, Adam; Solanas, Montserrat] Univ Autonoma Barcelona, Fac Med, Dept Cell Biol Physiol & Immunol, Med Physiol Unit, Bellaterra 08193, Spain.
   [Alvarez-Monell, Adam; Subias-Gusils, Alex; Belda, Xavier; Gagliano, Humberto; Armario, Antonio; Solanas, Montserrat; Escorihuela, Rosa M.] Univ Autonoma Barcelona, Inst Neurociencies, Bellaterra 08193, Spain.
   [Subias-Gusils, Alex] Univ Autonoma Barcelona, Dept Psiquiatria & Med Legal, Unitat Psicol Med, Bellaterra 08193, Spain.
   [Marine-Casado, Roger; Boque, Noemi; Caimari, Antoni] Ctr Tecnol Catalunya, Biotechnol Area & Technol Unit Nutr & Hlth, Eurecat, Reus 43204, Spain.
   [Belda, Xavier; Gagliano, Humberto; Armario, Antonio; Escorihuela, Rosa M.] Univ Autonoma Barcelona, Fac Biosci, Dept Cell Biol Physiol & Immunol, Anim Physiol Unit, Bellaterra 08193, Spain.
   [Pozo, Oscar J.] IMIM Hosp Mar Med Res Inst, Gastroesophageal Carcinogenesis Grp, Carrer Doctor Aiguader 88, Barcelona 08003, Spain.
C3 Autonomous University of Barcelona; Autonomous University of Barcelona;
   Autonomous University of Barcelona; Autonomous University of Barcelona;
   Hospital del Mar Research Institute
RP Solanas, M (corresponding author), Univ Autonoma Barcelona, Fac Med, Dept Cell Biol Physiol & Immunol, Med Physiol Unit, Bellaterra 08193, Spain.; Solanas, M; Escorihuela, RM (corresponding author), Univ Autonoma Barcelona, Inst Neurociencies, Bellaterra 08193, Spain.; Escorihuela, RM (corresponding author), Univ Autonoma Barcelona, Fac Biosci, Dept Cell Biol Physiol & Immunol, Anim Physiol Unit, Bellaterra 08193, Spain.
EM Montserrat.Solanas@uab.cat; Rosamaria.Escorihuela@uab.cat
RI Gagliano, Humberto/C-9695-2011; Armario, Antonio/C-9267-2011; Solanas,
   Montserrat/AGN-1896-2022; Pozo, Oscar/I-1615-2019; Belda,
   Xavier/C-9103-2011; Escorihuela, Rosa M/L-4524-2014
OI Subias-Gusils, Alex/0000-0001-6981-7383; Belda,
   Xavier/0000-0003-0374-9546; Escorihuela, Rosa M/0000-0001-9368-5173;
   Marine-Casado, Roger/0000-0002-0924-4920; Alvarez-Monell,
   Adam/0000-0003-4806-3361; SOLANAS GARCIA, MONTSERRAT/0000-0003-2949-1344
FU Spanish Ministerio de Economia, Industria y Competitividad
   [PSI2016-77234-R]; Universitat Autonoma de Barcelona [PIF-UAB2018];
   Ministerio de Ciencia e Innovacion [BES-2017-081939]; Catalan Government
FX This research was funded by the Spanish Ministerio de Economia,
   Industria y Competitividad, grant number PSI2016-77234-R. A.A-M. is
   granted by the Universitat Autonoma de Barcelona, grant PIF-UAB2018.
   A.S.-G. is granted by the Ministerio de Ciencia e Innovacion, grant
   number BES-2017-081939. This work was also financially supported by the
   Catalan Government through the funding grant ACCIO-EURECAT. The funding
   sources had no involvement in study design, collection, analysis and
   interpretation of data, the writing of the report and the decision to
   submit the article for publication.
CR Abd Al Haleem EN, 2019, CHEM-BIOL INTERACT, V302, P108, DOI 10.1016/j.cbi.2019.01.022
   Alhassan S, 2008, INT J OBESITY, V32, P985, DOI 10.1038/ijo.2008.8
   Armario Antonio, 2006, CNS & Neurological Disorders-Drug Targets, V5, P485, DOI 10.2174/187152706778559336
   Atlantis E, 2004, PREV MED, V39, P424, DOI 10.1016/j.ypmed.2004.02.007
   Blüher M, 2020, ENDOCR REV, V41, P405, DOI 10.1210/endrev/bnaa004
   Bravo R, 2014, CHRONOBIOL INT, V31, P363, DOI 10.3109/07420528.2013.859151
   Burghardt PR, 2004, BRAIN RES, V1019, P84, DOI 10.1016/j.brainres.2004.05.086
   Cameron I, 2012, CAN J PHYSIOL PHARM, V90, P1490, DOI [10.1139/Y2012-097, 10.1139/y2012-097]
   Champaneri S, 2013, OBESITY, V21, pE56, DOI 10.1002/oby.20047
   Chan AML, 2021, NUTRIENTS, V13, DOI 10.3390/nu13082497
   Chin SH, 2016, OBES REV, V17, P1226, DOI 10.1111/obr.12460
   Cigarroa I, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0153687
   Daviu N, 2014, STRESS, V17, P176, DOI 10.3109/10253890.2014.880834
   ENGELAND WC, 1989, ENDOCRINOLOGY, V124, P2978, DOI 10.1210/endo-124-6-2978
   Erickson KI, 2011, P NATL ACAD SCI USA, V108, P3017, DOI 10.1073/pnas.1015950108
   Fediuc S, 2006, J APPL PHYSIOL, V100, P1867, DOI 10.1152/japplphysiol.01416.2005
   Foright RM, 2020, AM J PHYSIOL-REG I, V319, pR171, DOI 10.1152/ajpregu.00259.2019
   Foster MT, 2009, ENDOCRINOLOGY, V150, P2325, DOI 10.1210/en.2008-1426
   Gardener H, 2020, J ALZHEIMERS DIS, V78, P1653, DOI 10.3233/JAD-201071
   Geiger BM, 2009, NEUROSCIENCE, V159, P1193, DOI 10.1016/j.neuroscience.2009.02.007
   Gomez-Gomez A, 2020, J CHROMATOGR A, V1624, DOI 10.1016/j.chroma.2020.461179
   Gual-Grau A, 2019, J NUTR BIOCHEM, V71, P122, DOI 10.1016/j.jnutbio.2019.06.005
   Hamjane N, 2020, MICROVASC RES, V131, DOI 10.1016/j.mvr.2020.104023
   Han ES, 2001, J GERONTOL A-BIOL, V56, pB391, DOI 10.1093/gerona/56.9.B391
   Harvey SB, 2018, AM J PSYCHIAT, V175, P28, DOI 10.1176/appi.ajp.2017.16111223
   Heffron SP, 2020, CIRC RES, V126, P1646, DOI 10.1161/CIRCRESAHA.119.315897
   IXART G, 1977, J ENDOCRINOL, V72, P113, DOI 10.1677/joe.0.0720113
   Jurdak N, 2008, NUTR NEUROSCI, V11, P48, DOI 10.1179/147683008X301333
   Kaptan Z, 2019, BRAIN RES, V1721, DOI 10.1016/j.brainres.2019.146326
   Karelis AD, 2005, J CLIN ENDOCR METAB, V90, P4145, DOI 10.1210/jc.2005-0482
   Kleinert M, 2018, NAT REV ENDOCRINOL, V14, P140, DOI 10.1038/nrendo.2017.161
   Kohsaka A, 2007, CELL METAB, V6, P414, DOI 10.1016/j.cmet.2007.09.006
   Kurhe Y, 2015, BIOCHEM BIOPH RES CO, V456, P74, DOI 10.1016/j.bbrc.2014.11.036
   la Fleur SE, 2005, ENDOCRINOLOGY, V146, P2193, DOI 10.1210/en.2004-1603
   Lalanza JF, 2021, NEUROSCI BIOBEHAV R, V122, P92, DOI 10.1016/j.neubiorev.2020.11.003
   Lalanza JF, 2015, SCI REP-UK, V5, DOI 10.1038/srep16166
   Lalanza JF, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0085049
   Lalanza JF, 2012, PSYCHONEUROENDOCRINO, V37, P1745, DOI 10.1016/j.psyneuen.2012.03.008
   Leigh SJ, 2020, NUTR METAB, V17, DOI 10.1186/s12986-020-00492-6
   Lucassen EA, 2012, CURR OBES REP, V1, P208, DOI 10.1007/s13679-012-0028-5
   Martire SI, 2015, PHYSIOL BEHAV, V139, P80, DOI 10.1016/j.physbeh.2014.11.006
   Martire SI, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0060407
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mayengbam S, 2019, J PROTEOME RES, V18, P3867, DOI 10.1021/acs.jproteome.9b00304
   McKay N, 2021, PHYSIOL BEHAV, V229, DOI 10.1016/j.physbeh.2020.113216
   Mifune H, 2015, PEPTIDES, V71, P49, DOI 10.1016/j.peptides.2015.06.007
   Moradi F, 2021, CLIN NUTR ESPEN, V45, P399, DOI 10.1016/j.clnesp.2021.07.013
   Murtagh EM, 2015, PREV MED, V72, P34, DOI 10.1016/j.ypmed.2014.12.041
   Novelli M, 2004, EXP GERONTOL, V39, P1333, DOI 10.1016/j.exger.2004.06.014
   Pinheiro-Mulder A, 2010, PATHOL RES PRACT, V206, P168, DOI 10.1016/j.prp.2009.11.004
   Ramos-Lopez O, 2018, CHRONOBIOL INT, V35, P969, DOI 10.1080/07420528.2018.1446021
   Rodriguez ACI, 2015, PSYCHONEUROENDOCRINO, V62, P301, DOI 10.1016/j.psyneuen.2015.08.014
   Romanelli R, 2020, ITAL J PEDIATR, V46, DOI 10.1186/s13052-020-00868-7
   Rotllant D, 2007, DEV NEUROBIOL, V67, P702, DOI 10.1002/dneu.20345
   Sampey BP, 2011, OBESITY, V19, P1109, DOI 10.1038/oby.2011.18
   Sanchís-Oll M, 2021, NEUROBIOL STRESS, V15, DOI 10.1016/j.ynstr.2021.100355
   Schibler U, 2002, CELL, V111, P919, DOI 10.1016/S0092-8674(02)01225-4
   SCLAFANI A, 1976, PHYSIOL BEHAV, V17, P461, DOI 10.1016/0031-9384(76)90109-8
   Scorrano F, 2015, FASEB J, V29, P859, DOI 10.1096/fj.14-254474
   Sharma S, 2013, INT J OBESITY, V37, P382, DOI 10.1038/ijo.2012.48
   Shimizu N, 2020, BIOL PHARM BULL, V43, P1279, DOI 10.1248/bpb.b20-00235
   Sieverdes JC, 2010, BRIT J SPORT MED, V44, P238, DOI 10.1136/bjsm.2009.062117
   Small L, 2018, AM J PHYSIOL-ENDOC M, V314, pE251, DOI 10.1152/ajpendo.00337.2017
   Song MK, 2021, PHYSIOL BEHAV, V237, DOI 10.1016/j.physbeh.2021.113440
   Subias-Gusils A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124474
   Subias-Gusils A, 2021, INT J FOOD SCI NUTR, V72, P767, DOI 10.1080/09637486.2020.1870037
   Swierczynska MM, 2015, INT J OBESITY, V39, P321, DOI 10.1038/ijo.2014.102
   Therrien F, 2007, OBESITY, V15, P377, DOI 10.1038/oby.2007.509
   Trouwborst I, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051588
   Turek FW, 2005, SCIENCE, V308, P1043, DOI 10.1126/science.1108750
   Ulrich-Lai YM, 2010, P NATL ACAD SCI USA, V107, P20529, DOI 10.1073/pnas.1007740107
   Vgontzas AN, 2007, J CLIN ENDOCR METAB, V92, P4199, DOI 10.1210/jc.2007-0774
   Ward ZJ, 2019, NEW ENGL J MED, V381, P2440, DOI 10.1056/NEJMsa1909301
   Willmann C, 2019, AM J CLIN NUTR, V109, P288, DOI 10.1093/ajcn/nqy307
   Yumuk V, 2015, OBESITY FACTS, V8, P402, DOI 10.1159/000442721
   Zeeni N, 2015, PHYSIOL BEHAV, V139, P41, DOI 10.1016/j.physbeh.2014.11.003
   Zelena D, 2003, AM J PHYSIOL-ENDOC M, V285, pE1110, DOI 10.1152/ajpendo.00219.2003
   Ziarniak K, 2021, ACTA HISTOCHEM, V123, DOI 10.1016/j.acthis.2021.151751
NR 78
TC 4
Z9 4
U1 4
U2 12
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD NOV 15
PY 2022
VL 12
IS 1
AR 19545
DI 10.1038/s41598-022-23464-7
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 6H0KC
UT WOS:000885139000062
PM 36379981
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Warolin, J
   Coenen, KR
   Kantor, JL
   Whitaker, LE
   Wang, L
   Acra, SA
   Roberts, LJ
   Buchowski, MS
AF Warolin, J.
   Coenen, K. R.
   Kantor, J. L.
   Whitaker, L. E.
   Wang, L.
   Acra, S. A.
   Roberts, L. J., II
   Buchowski, M. S.
TI The relationship of oxidative stress, adiposity and metabolic risk
   factors in healthy Black and White American youth
SO PEDIATRIC OBESITY
LA English
DT Article
DE Adiposity; isoprostane; metabolic syndrome
ID HOMEOSTASIS MODEL ASSESSMENT; CORONARY-HEART-DISEASE;
   INSULIN-RESISTANCE; OBESE CHILDREN; VISCERAL FAT; SENSITIVITY;
   ADOLESCENTS; SERUM; COMPLICATIONS; ISOPROSTANE
AB BackgroundOxidative stress is elevated in obese youth, but less is known regarding racial disparities in the relationship of oxidative stress with metabolic risk factors.
   ObjectivesTo determine the relationship between oxidative stress and metabolic risk factors, adiposity, leptin, adiponectin and cardiovascular fitness (VO2PEAK) in healthy African American and White American youth.
   MethodsA marker of oxidative stress (F-2-isoprostane), validated markers of metabolic risk factors, fitness and body composition were measured in African American (n=82) and White American (n=76) youth (8-17 years old) recruited over a range of BMI percentiles (4th to 99th).
   ResultsF(2)-isoprostane concentration was positively correlated with percentage body fat (r=0.198) and percentage truncal fat (r=0.173), but was not different between African American and White American males and females (P=0.208). African American youth had significantly higher mean systolic and diastolic blood pressure (P=0.023 and P=0.011, respectively), body weight, BMI percentile and Tanner stage. After adjusting for gender, age, BMI and Tanner stage, African American youth varied from White Americans in the association of F-2-isoprostane with diastolic blood pressure (P=0.047), but not with systolic blood pressure, triglycerides, VO2PEAK or homeostatic model assessment for insulin resistance (all P>0.05).
   ConclusionsOxidative stress, as measured by urinary F-2-isoprostane concentrations, was positively associated with percent body fat and truncal fat in youth. Oxidative stress levels were similar among African American and White American youth. Among markers of the metabolic syndrome, a significant difference between African American and White American youth was demonstrated only in the association of oxidative stress with diastolic blood pressure.
C1 [Warolin, J.; Kantor, J. L.; Acra, S. A.] Vanderbilt Univ, Med Ctr, Div Gastroenterol, Dept Pediat, Nashville, TN 37232 USA.
   [Coenen, K. R.; Whitaker, L. E.; Buchowski, M. S.] Vanderbilt Univ, Med Ctr, Div Gastroenterol, Dept Med, Nashville, TN 37232 USA.
   [Wang, L.] Vanderbilt Univ, Med Ctr, Dept Biostat, Nashville, TN 37232 USA.
   [Roberts, L. J., II] Vanderbilt Univ, Med Ctr, Dept Clin Pharmacol, Dept Med, Nashville, TN 37232 USA.
C3 Vanderbilt University; Vanderbilt University; Vanderbilt University;
   Vanderbilt University
RP Buchowski, MS (corresponding author), Vanderbilt Univ, Med Ctr, A-4103 MCN,1161 21st Ave South, Nashville, TN 37232 USA.
EM maciej.buchowski@vanderbilt.edu
OI Buchowski, Maciej/0000-0002-0566-1743
FU NIH [RO1HL082988, DK20593]; National Center for Research Resources at
   the National Center for Advancing Translational Sciences [UL1
   RR024975-01, 2 UL1 TR000445-06]; Vanderbilt Research Training in
   Diabetes and Endocrinology grant [NIH T32 DK07061-35]; NIDDK training
   grant [NIH T32 DK007673-17]; NIH MERIT Award [GM42056]
FX This work was supported by grants from the NIH (RO1HL082988) and the
   National Center for Research Resources, Grant UL1 RR024975-01, and is
   now at the National Center for Advancing Translational Sciences, Grant 2
   UL1 TR000445-06. KRC was supported by a Vanderbilt Research Training in
   Diabetes and Endocrinology grant (NIH T32 DK07061-35) and JW by a NIDDK
   training grant (NIH T32 DK007673-17). Additional support came from an
   NIH MERIT Award (GM42056) awarded to LJR. The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the National Institute of Health. Hormone, lipid and
   isoprostane assays were performed in the core laboratories of the
   Vanderbilt Diabetes Research and Training Center supported by NIH grant
   DK20593. We would like to thank Stephane Daphnis, Denise Dunlap, Cindy
   Dorminy, Natalie Meade, Elizabeth Provenzano and Daniel Short for their
   contributions to the acquisition of the data for this study.
CR Adam TC, 2011, DIABETES CARE, V34, P994, DOI 10.2337/dc10-1593
   [Anonymous], J PEDIAT
   Apak R, 2010, METHODS MOL BIOL, V594, P215, DOI 10.1007/978-1-60761-411-1_15
   Araki S, 2010, EUR J PEDIATR, V169, P965, DOI 10.1007/s00431-010-1157-z
   Brownlee M, 2005, DIABETES, V54, P1615, DOI 10.2337/diabetes.54.6.1615
   BRUCE RA, 1971, ANN CLIN RES, V3, P323
   CDC, 2009, NATIONAL HEALTH AND
   Centers for Disease Control and Prevention, 2000, CDC GROWTH CHARTS UN
   Ceriello A, 2008, DIABETES CARE, V31, pS181, DOI 10.2337/dc08-s245
   Clark LT, 2007, CLIN CARDIOL, V30, P161, DOI 10.1002/clc.20003
   Clasey JL, 1999, OBES RES, V7, P256, DOI 10.1002/j.1550-8528.1999.tb00404.x
   Codoñer-Franch P, 2010, INT J PEDIATR OBES, V5, P56, DOI 10.3109/17477160903055945
   Conwell LS, 2004, DIABETES CARE, V27, P314, DOI 10.2337/diacare.27.2.314
   Cook S, 2003, ARCH PEDIAT ADOL MED, V157, P821, DOI 10.1001/archpedi.157.8.821
   Cossrow N, 2004, J CLIN ENDOCR METAB, V89, P2590, DOI 10.1210/jc.2004-0339
   Cruz ML, 2002, HYPERTENSION, V40, P18, DOI 10.1161/01.HYP.0000019972.37690.EF
   d'Annunzio Giuseppe, 2009, Acta Biomed, V80, P21
   Dávalos A, 2004, J AGR FOOD CHEM, V52, P48, DOI 10.1021/jf0305231
   DONAHUE RP, 1989, ARTERIOSCLEROSIS, V9, P656, DOI 10.1161/01.ATV.9.5.656
   Freedman DS, 1999, PEDIATRICS, V103, P1175, DOI 10.1542/peds.103.6.1175
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Giannini C, 2009, EUR J ENDOCRINOL, V161, P73, DOI 10.1530/EJE-09-0042
   Grossman E, 2008, DIABETES CARE, V31, pS185, DOI 10.2337/dc08-s246
   Gungor N, 2004, J PEDIATR-US, V144, P47, DOI 10.1016/j.jpeds.2003.09.045
   Hannon TS, 2005, PEDIATRICS, V116, P473, DOI 10.1542/peds.2004-2536
   Hoffman RP, 2009, CURR DIABETES REV, V5, P259, DOI 10.2174/157339909789804332
   Kadiiska MB, 2005, FREE RADICAL BIO MED, V38, P698, DOI 10.1016/j.freeradbiomed.2004.09.017
   Kelly Aaron S, 2006, J Cardiometab Syndr, V1, P248, DOI 10.1111/j.1559-4564.2006.05758.x
   Keskin M, 2005, PEDIATRICS, V115, pE500, DOI 10.1542/peds.2004-1921
   Levy-Marchal C, 2010, J CLIN ENDOCR METAB, V95, P5189, DOI 10.1210/jc.2010-1047
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Milne GL, 2011, CHEM REV, V111, P5973, DOI 10.1021/cr200160h
   MORROW JD, 1990, P NATL ACAD SCI USA, V87, P9383, DOI 10.1073/pnas.87.23.9383
   Morrow JD, 1999, ANAL BIOCHEM, V269, P326, DOI 10.1006/abio.1999.4008
   Natl High Blood Pressure Educ Prog, 2004, PEDIATRICS, V114, P555
   Ogden CL, 2006, JAMA-J AM MED ASSOC, V295, P1549, DOI 10.1001/jama.295.13.1549
   Oliver SR, 2010, INT J PEDIATR OBES, V5, P436, DOI 10.3109/17477160903545163
   Ostrow V, 2011, J PEDIATR-US, V158, P628, DOI 10.1016/j.jpeds.2010.09.081
   Robertson RP, 2004, J BIOL CHEM, V279, P42351, DOI 10.1074/jbc.R400019200
   Rodrigo R, 2007, HYPERTENS RES, V30, P1159, DOI 10.1291/hypres.30.1159
   Schwedhelm E, 2004, CIRCULATION, V109, P843, DOI 10.1161/01.CIR.0000116761.93647.30
   Shaibi GQ, 2011, INT J PEDIATR OBES, V6, pE290, DOI 10.3109/17477166.2010.528766
   Sinaiko AR, 2005, CIRCULATION, V111, P1985, DOI 10.1161/01.CIR.0000161837.23846.57
   SRINIVASAN SR, 1976, CIRCULATION, V54, P309, DOI 10.1161/01.CIR.54.2.309
   Stein E, 2007, METABOLISM, V56, P954, DOI 10.1016/j.metabol.2007.02.008
   Stringer DM, 2009, PEDIATR DIABETES, V10, P269, DOI 10.1111/j.1399-5448.2008.00473.x
   Sumner AE, 2008, ATHEROSCLEROSIS, V196, P696, DOI 10.1016/j.atherosclerosis.2006.12.018
   Ustundag B, 2007, CELL BIOCHEM FUNCT, V25, P479, DOI 10.1002/cbf.1334
   Van Guilder GP, 2006, OBESITY, V14, P2127, DOI 10.1038/oby.2006.248
   YAGI K, 1976, BIOCHEM MED METAB B, V15, P212, DOI 10.1016/0006-2944(76)90049-1
   Yu SSK, 2012, METAB SYNDR RELAT D, V10, P77, DOI 10.1089/met.2011.0108
NR 51
TC 55
Z9 63
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-6310
EI 2047-6302
J9 PEDIATR OBES
JI Pediatr. Obes.
PD FEB
PY 2014
VL 9
IS 1
BP 43
EP 52
DI 10.1111/j.2047-6310.2012.00135.x
PG 10
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 292VY
UT WOS:000329932000009
PM 23296459
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Mann, JK
   Lutzker, L
   Holm, SM
   Margolis, HG
   Neophytou, AM
   Eisen, EA
   Costello, S
   Tyner, T
   Holland, N
   Tindula, G
   Prunicki, M
   Nadeau, K
   Noth, EM
   Lurmann, F
   Hammond, SK
   Balmes, JR
AF Mann, Jennifer K.
   Lutzker, Liza
   Holm, Stephanie M.
   Margolis, Helene G.
   Neophytou, Andreas M.
   Eisen, Ellen A.
   Costello, Sadie
   Tyner, Tim
   Holland, Nina
   Tindula, Gwen
   Prunicki, Mary
   Nadeau, Kari
   Noth, Elizabeth M.
   Lurmann, Fred
   Hammond, S. Katharine
   Balmes, John R.
TI Traffic-related air pollution is associated with glucose dysregulation,
   blood pressure, and oxidative stress in children
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE Children; Metabolic syndrome; HbA1c; Oxidative stress; Traffic-related
   air pollution; Polycyclic aromatic hydrocarbons
ID POLYCYCLIC AROMATIC-HYDROCARBONS; INTIMA-MEDIA THICKNESS; LONG-TERM
   EXPOSURE; BODY-MASS INDEX; INSULIN-RESISTANCE; LIPID-PEROXIDATION; US
   CHILDREN; CHILDHOOD; OBESITY; INFLAMMATION
AB Background: Metabolic syndrome increases the risk of cardiovascular disease in adults. Antecedents likely begin in childhood and whether childhood exposure to air pollution plays a contributory role is not well understood. Objectives: To assess whether children's exposure to air pollution is associated with markers of risk for metabolic syndrome and oxidative stress, a hypothesized mediator of air pollution-related health effects.
   Methods: We studied 299 children (ages 6-8) living in the Fresno, CA area. At a study center visit, questionnaire and biomarker data were collected. Outcomes included hemoglobin A1c (HbA1c), urinary 8-isoprostane, systolic blood pressure (SBP), and BMI. Individual-level exposure estimates for a set of four pollutants that are constituents of traffic-related air pollution (TRAP) - the sum of 4-, 5-, and 6-ring polycyclic aromatic hydrocarbon compounds (PAH456), NO2, elemental carbon, and fine particulate matter (PM2.5) - were modeled at the primary residential location for 1-day lag, and 1-week, 1-month, 3-month, 6-month, and 1-year averages prior to each participant's visit date. Generalized additive models were used to estimate associations between each air pollutant exposure and outcome.
   Results: The study population was 53% male, 80% Latinx, 11% Black and largely low-income (6% were White and 3% were Asian/Pacific Islander). HbA1c percentage was associated with longer-term increases in TRAP; for example a 4.42 ng/m(3) increase in 6-month average PAH456 was associated with a 0.07% increase (95% CI: 0.01, 0.14) and a 3.62 mu g/m(3) increase in 6-month average PM2.5 was associated with a 0.06% increase (95% CI: 0.01, 0.10). The influence of air pollutants on blood pressure was strongest at 3 months; for example, a 6.2 ppb increase in 3-month average NO2 was associated with a 9.4 mmHg increase in SBP (95% CI: 2.8, 15.9). TRAP concentrations were not significantly associated with anthropometric or adipokine measures. Short-term TRAP exposure averages were significantly associated with creatinine-adjusted urinary 8-isoprostane.
   Discussion: Our results suggest that both short- and longer-term estimated individual-level outdoor residential exposures to several traffic-related air pollutants, including ambient PAHs, are associated with biomarkers of risk for metabolic syndrome and oxidative stress in children.
C1 [Mann, Jennifer K.; Lutzker, Liza; Holm, Stephanie M.; Neophytou, Andreas M.; Eisen, Ellen A.; Costello, Sadie; Holland, Nina; Tindula, Gwen; Noth, Elizabeth M.; Hammond, S. Katharine; Balmes, John R.] Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA.
   [Margolis, Helene G.] Univ Calif Davis, Dept Internal Med, Davis, CA 95616 USA.
   [Neophytou, Andreas M.] Colorado State Univ, Dept Environm & Radiol Hlth Sci, Ft Collins, CO 80523 USA.
   [Tyner, Tim] Univ Calif San Francisco Fresno, Fresno, CA USA.
   [Tyner, Tim] Cent Calif Asthma Collaborat, Fresno, CA USA.
   [Prunicki, Mary; Nadeau, Kari] Stanford Univ, Sean N Parker Ctr Allergy & Asthma Res, Palo Alto, CA 94304 USA.
   [Lurmann, Fred] Sonoma Technol, Petaluma, CA USA.
   [Holm, Stephanie M.; Balmes, John R.] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA.
C3 University of California System; University of California Berkeley;
   University of California System; University of California Davis;
   Colorado State University System; Colorado State University Fort
   Collins; University of California System; University of California San
   Francisco; University of California San Francisco at Fresno; Stanford
   University; Sonoma Technology, Inc.; University of California System;
   University of California San Francisco
RP Balmes, JR (corresponding author), Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA.
EM jbalmes@berkeley.edu
RI Lutzker, Liza/MAI-3669-2025; Neophytou, Andreas/MTE-0808-2025; Balmes,
   John/L-6281-2019; Holm, Stephanie/AAC-7456-2020
OI Lutzker, Elizabeth/0000-0003-0611-0158; Costello,
   Sadie/0000-0001-6181-5666
FU Children's Health and Air Pollution Study (CHAPS), an NIH/EPA [EPA:
   RD83543501, NIH: ES022849, NIH: F31ES0277510]; National Institute for
   Occupational Safety and Health [T42OH008429] Funding Source: NIH
   RePORTER; National Institute of Environmental Health Sciences
   [R24ES030888] Funding Source: NIH RePORTER
FX This research was supported by the Children's Health and Air Pollution
   Study (CHAPS), an NIH/EPA-funded Children's Environmental Health
   Research Center (EPA: RD83543501, NIH: ES022849) and an additional grant
   (NIH: F31ES0277510). The content is solely the responsibility of the
   authors and does not necessarily represent the official views of the
   National Institutes of Health. Gwen Tindula received a Student/New
   Investigator Travel Award of $750.00 to attend and present at the 2019
   Environmental Mutagenesis and Genomics Society (EMGS) meeting in
   Washington DC from September 19-23.
CR Alderete TL, 2017, DIABETES, V66, P1789, DOI 10.2337/db16-1416
   Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
   An RP, 2018, INT J OBESITY, V42, P1112, DOI 10.1038/s41366-018-0089-y
   [Anonymous], 2016, A SAS Program for the 2000 CDC Growth Charts (ages 0 to 20 years)
   Babey Susan H, 2016, Policy Brief UCLA Cent Health Policy Res, P1
   Brook RD, 2009, HYPERTENSION, V54, P659, DOI 10.1161/HYPERTENSIONAHA.109.130237
   Center for Disease Control and Prevention, 2011, NATL HLTH NUTR EXAMI, DOI [11-2012/manuals/Muscle_Strength_Proc_Manual.pdf, DOI 11-2012/MANUALS/MUSCLE_STRENGTH_PROC_MANUAL.PDF]
   Chen C, 2007, ENVIRON HEALTH PERSP, V115, P1732, DOI 10.1289/ehp.10294
   Chen W, 2015, ATHEROSCLEROSIS, V240, P374, DOI 10.1016/j.atherosclerosis.2015.04.002
   Chen XL, 2008, CIRCULATION, V117, P3171, DOI 10.1161/CIRCULATIONAHA.107.730366
   Chiu YHM, 2017, ENVIRON RES, V158, P798, DOI 10.1016/j.envres.2017.07.026
   Erhardt E, 2014, INT J OBESITY, V38, pS32, DOI 10.1038/ijo.2014.133
   Eze IC, 2015, ENVIRON HEALTH PERSP, V123, P381, DOI 10.1289/ehp.1307823
   Faienza MF, 2016, INTERN EMERG MED, V11, P175, DOI 10.1007/s11739-015-1382-6
   Gall S, 2014, EUR HEART J, V35, P2484, DOI 10.1093/eurheartj/ehu049
   GORAN MI, 1993, J APPL PHYSIOL, V75, P1776, DOI 10.1152/jappl.1993.75.4.1776
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Hutcheson R, 2012, EXP DIABETES RES, DOI 10.1155/2012/271028
   Koskinen J, 2019, HYPERTENSION, V73, P335, DOI 10.1161/HYPERTENSIONAHA.118.12225
   Li M, 2015, ATMOS ENVIRON, V117, P227, DOI 10.1016/j.atmosenv.2015.07.029
   Li N, 2020, ENVIRON RES, V182, DOI 10.1016/j.envres.2019.109109
   Li W, 2018, ENVIRON INT, V111, P14, DOI 10.1016/j.envint.2017.11.010
   Li WY, 2016, OBESITY, V24, P2593, DOI 10.1002/oby.21630
   Li WY, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.115.002742
   Lim CC, 2019, CURR DIABETES REP, V19, DOI 10.1007/s11892-019-1181-y
   Ma CW, 2016, HYPERTENSION, V68, P614, DOI 10.1161/HYPERTENSIONAHA.116.07659
   Margolis HG, 2009, INT J ENVIRON HEAL R, V19, P139, DOI 10.1080/09603120802415792
   McConnell R, 2015, ENVIRON HEALTH PERSP, V123, P360, DOI 10.1289/ehp.1307031
   Moody EC, 2019, JAMA NETW OPEN, V2, DOI 10.1001/jamanetworkopen.2019.17643
   Nardone A, 2020, LANCET PLANET HEALTH, V4, pE24, DOI 10.1016/S2542-5196(19)30241-4
   Noth EM, 2020, ATMOS ENVIRON, V242, DOI 10.1016/j.atmosenv.2020.117818
   Noth EM, 2016, AIR QUAL ATMOS HLTH, V9, P899, DOI 10.1007/s11869-016-0399-y
   Noth EM, 2011, ATMOS ENVIRON, V45, P2394, DOI 10.1016/j.atmosenv.2011.02.014
   Özkaynak H, 2013, J EXPO SCI ENV EPID, V23, P566, DOI 10.1038/jes.2013.15
   Ogden CL, 2012, JAMA-J AM MED ASSOC, V307, P483, DOI [10.1001/jama.2012.39, 10.1001/jama.2012.40]
   Park SK, 2017, DIABETES, V66, P1755, DOI 10.2337/dbi17-0012
   Piya MK, 2013, J ENDOCRINOL, V216, pT1, DOI 10.1530/JOE-12-0498
   Poursafa P, 2018, ENVIRON INT, V118, P203, DOI 10.1016/j.envint.2018.05.048
   Rajagopalan S, 2012, DIABETES, V61, P3037, DOI 10.2337/db12-0190
   Roberts LJ, 2000, FREE RADICAL BIO MED, V28, P505, DOI 10.1016/S0891-5849(99)00264-6
   Rundle A, 2012, AM J EPIDEMIOL, V175, P1163, DOI 10.1093/aje/kwr455
   San Francisco Unified School District, 2017, 2017 MIDDL SCH SFUSD
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Sun QH, 2009, CIRCULATION, V119, P538, DOI 10.1161/CIRCULATIONAHA.108.799015
   Sun SS, 2007, PEDIATRICS, V119, P237, DOI 10.1542/peds.2006-2543
   Tager IB, 2005, EPIDEMIOLOGY, V16, P751, DOI 10.1097/01.ede.0000183166.68809.b0
   Thiering E, 2015, TRENDS ENDOCRIN MET, V26, P384, DOI 10.1016/j.tem.2015.05.002
   Toledo-Corral CM, 2018, PEDIATR OBES, V13, P54, DOI 10.1111/ijpo.12188
   Tran V, 2017, J DEV ORIG HLTH DIS, V8, P196, DOI [10.1017/S2040174416000763, 10.1017/s2040174416000763]
   Trasande L, 2015, ENVIRON RES, V136, P133, DOI 10.1016/j.envres.2014.08.038
   van't Erve TJ, 2016, FREE RADICAL BIO MED, V95, P65, DOI 10.1016/j.freeradbiomed.2016.03.001
   Vijayakumar P, 2017, DIABETES CARE, V40, P16, DOI 10.2337/dc16-1358
   Volberg V, 2013, PEDIATR OBES, V8, P454, DOI 10.1111/j.2047-6310.2012.00127.x
   Wang Y, 2014, J OCCUP ENVIRON MED, V56, pE73, DOI 10.1097/JOM.0000000000000253
   Wolf K, 2016, DIABETES, V65, P3314, DOI 10.2337/db15-1567
   Xi B, 2016, AM J HYPERTENS, V29, P217, DOI 10.1093/ajh/hpv091
   Yang BY, 2018, ENVIRON POLLUT, V235, P576, DOI 10.1016/j.envpol.2018.01.001
   Zeng XW, 2017, ENVIRON POLLUT, V224, P698, DOI 10.1016/j.envpol.2017.02.054
   Zhang YY, 2016, ENVIRON POLLUT, V213, P809, DOI 10.1016/j.envpol.2016.03.050
   Zuk M., 2013, THESIS U CALIFORNIA
NR 60
TC 30
Z9 33
U1 0
U2 36
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
EI 1096-0953
J9 ENVIRON RES
JI Environ. Res.
PD APR
PY 2021
VL 195
AR 110870
DI 10.1016/j.envres.2021.110870
EA FEB 2021
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA RM0BZ
UT WOS:000639328800149
PM 33587949
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Fan, HX
   Wang, YL
   Ren, ZY
   Liu, XC
   Zhao, JQ
   Yuan, YL
   Fei, XN
   Song, XS
   Wang, FQ
   Liang, B
AF Fan, Hongxuan
   Wang, Yongle
   Ren, Zhaoyu
   Liu, Xuchang
   Zhao, Jianqi
   Yuan, Yalin
   Fei, Xiaoning
   Song, Xiaosu
   Wang, Fengqin
   Liang, Bin
TI Mediterranean diet lowers all-cause and cardiovascular mortality for
   patients with metabolic syndrome
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
ID INSULIN-RESISTANCE; SEDENTARY BEHAVIOR; PHYSICAL-ACTIVITY;
   UNITED-STATES; DEPRESSION; CARBOHYDRATE; PREVALENCE; OBESITY; ADULTS;
   TRENDS
AB A Mediterranean-style diet (MED) can promote people lengthen the span of life and avoid atherosclerotic cardiovascular disease (ASCVD) in primary prevention. Metabolic syndrome (MetS) can significantly reduce life expectancy and increase the risk of ASCVD. However, few studies have focused on the role of the Mediterranean diet in patients with MetS. Participants in the National Health and Nutrition Examination Survey (NHANES) with MetS (N = 8301) from 2007 to 2018 were examined. A 9-point evaluation scorewas used to measure the degree of adherence to the MED diet. In order to compare the various levels of adherence to the MED diet and the effects of the specific MED diet components on all-cause and cardiovascular mortality, Cox regression models were utilized. Among the 8301 participants with MetS, about 13.0% (1080 of 8301) died after a median follow-up of 6.3 years. In this study, participants with MetS with adherence to high-quality and moderate-quality Mediterranean diet were significantly associated with lower all-cause mortality as well as cardiovascular mortality during the follow-up period. Futhermore, in joint analysis of the Mediterranean diet and sedentary behavior or depression, we found that high-quality or moderate-quality Mediterranean diet could attenuate, even reverse the adverse effects of sedentary behavior and depression on all-cause and cardiovascular mortality in participants with MetS. Among the components of the MED diet, greater intakes of vegetables, legumes, nuts and high MUFA/SFA ratio were significantly associated with lower all-cause mortality and greater vegetables intake was significantly associated with lower cardiovascular mortality, while more red/processed meat intake was significantly associated with higher cardiovascular mortality in participants with MetS.
C1 [Fan, Hongxuan; Ren, Zhaoyu; Zhao, Jianqi; Yuan, Yalin; Song, Xiaosu; Liang, Bin] Shanxi Med Univ, Dept Cardiol, Hosp 2, 382 Wuyi Rd, Taiyuan 030001, Shanxi, Peoples R China.
   [Wang, Yongle] Shanxi Med Univ, Dept Neurol, Hosp 1, 85 Jiefang South Rd, Taiyuan 030001, Shanxi, Peoples R China.
   [Liu, Xuchang] Shanxi Med Univ, Dept Urol, Hosp 1, 85 Jiefang South Rd, Taiyuan 030001, Shanxi, Peoples R China.
   [Fei, Xiaoning] Shanxi Med Univ, 56 Xinjian South Rd, Taiyuan 030001, Shanxi, Peoples R China.
   [Wang, Fengqin] Yangquan First Peoples Hosp, Dept Cardiol, 167 South St, Yangquan 030001, Shanxi, Peoples R China.
C3 Shanxi Medical University; Shanxi Medical University; Shanxi Medical
   University; Shanxi Medical University
RP Liang, B (corresponding author), Shanxi Med Univ, Dept Cardiol, Hosp 2, 382 Wuyi Rd, Taiyuan 030001, Shanxi, Peoples R China.
EM tyliangbin@163.com
RI Li, Xuming/JLM-6754-2023; Liang, Bin/JHU-0581-2023
OI Fan, Hongxuan/0000-0002-1234-544X
FU National Natural Science Foundation of China [82270494]; Fund Program
   for the Scientific Activities of Selected Returned Overseas
   Professionals in Shanxi Province [20220043]; Shanxi Graduate Education
   Innovation Project [2022Y386]
FX This work was supported by National Natural Science Foundation of China
   (grant number 82270494), Fund Program for the Scientific Activities of
   Selected Returned Overseas Professionals in Shanxi Province
   (No.20220043) and Shanxi Graduate Education Innovation Project (grant
   number 2022Y386).
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   AL-Ishaq RK, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9090430
   Martínez-González MA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043134
   Levis Brooke, 2019, BMJ, V365, pl1476, DOI [10.1136/bmj.l1781, 10.1136/bmj.l1476]
   Arab L, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020275
   Bull FC, 2020, BRIT J SPORT MED, V54, P1451, DOI 10.1136/bjsports-2020-102955
   Cao C, 2022, JAMA ONCOL, V8, P395, DOI 10.1001/jamaoncol.2021.6590
   Cleland CL, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-1255
   Delgado-Lista J, 2022, LANCET, V399, P1876, DOI 10.1016/S0140-6736(22)00122-2
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Dregan A, 2020, JAMA PSYCHIAT, V77, P598, DOI 10.1001/jamapsychiatry.2019.4712
   Estruch R, 2018, NEW ENGL J MED, V378, DOI [10.1056/NEJMoa1800389, 10.1056/NEJMoa1200303, 10.1056/nejmoa1800389]
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Healy GN, 2011, EUR HEART J, V32, P590, DOI 10.1093/eurheartj/ehq451
   Hill MA, 2021, METABOLISM, V119, DOI 10.1016/j.metabol.2021.154766
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Huang YH, 2021, J AFFECT DISORDERS, V295, P1377, DOI 10.1016/j.jad.2021.09.005
   Jackson SE, 2019, DEPRESS ANXIETY, V36, P987, DOI 10.1002/da.22950
   Kawai T, 2021, AM J PHYSIOL-CELL PH, V320, pC375, DOI 10.1152/ajpcell.00379.2020
   Ke HT, 2022, NUTRIENTS, V14, DOI 10.3390/nu14224941
   Khan N, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010039
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Lemieux I, 2020, NUTRIENTS
   Lepore SM, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081829
   Liang KW, 2022, NUTRIENTS, V14, DOI 10.3390/nu14153203
   Mirabelli M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041066
   Myers J, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071652
   Neeland IJ, 2019, LANCET DIABETES ENDO, V7, P715, DOI 10.1016/S2213-8587(19)30084-1
   Neeland IJ, 2018, CIRCULATION, V137, P1391, DOI 10.1161/CIRCULATIONAHA.117.029617
   Palella E, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17010300
   Parilli-Moser I, 2021, CLIN NUTR, V40, P5556, DOI 10.1016/j.clnu.2021.09.020
   Pimenta AM, 2021, J AFFECT DISORDERS, V284, P183, DOI 10.1016/j.jad.2021.02.002
   Qian F, 2016, DIABETES CARE, V39, P1448, DOI 10.2337/dc16-0513
   Raffin J, 2023, AGEING RES REV, V83, DOI 10.1016/j.arr.2022.101807
   Richardson LA, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph191912762
   Roberts CK, 2013, COMPR PHYSIOL, V3, P1, DOI 10.1002/cphy.c110062
   Salki A, 2009, METABOLISM, V58, P708, DOI 10.1016/j.metabol.2009.01.013
   Salmon J, 2023, BRIT J SPORT MED, V57, P311, DOI 10.1136/bjsports-2022-105825
   Sánchez-Calvo B, 2021, J NUTR BIOCHEM, V94, DOI 10.1016/j.jnutbio.2021.108646
   Shai I, 2008, NEW ENGL J MED, V359, P229, DOI 10.1056/NEJMoa0708681
   Summerhill V, 2018, FRONT CARDIOVASC MED, V5, DOI 10.3389/fcvm.2018.00188
   Trichopoulou A, 2003, NEW ENGL J MED, V348, P2599, DOI 10.1056/NEJMoa025039
   Vignali R, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21020654
   Yang L, 2019, JAMA-J AM MED ASSOC, V321, P1587, DOI 10.1001/jama.2019.3636
   Zhang M, 2021, TRANSL PSYCHIAT, V11, DOI 10.1038/s41398-021-01759-z
   Zhou JL, 2022, CHEMOSPHERE, V291, DOI 10.1016/j.chemosphere.2021.132953
NR 46
TC 29
Z9 31
U1 4
U2 16
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD MAY 23
PY 2023
VL 15
IS 1
AR 107
DI 10.1186/s13098-023-01052-7
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA H2IM1
UT WOS:000994252500003
PM 37221569
OA gold
DA 2025-06-11
ER

PT J
AU Rani, V
   Deep, G
   Singh, RK
   Palle, K
   Yadav, UCS
AF Rani, Vibha
   Deep, Gagan
   Singh, Rakesh K.
   Palle, Komaraiah
   Yadav, Umesh C. S.
TI Oxidative stress and metabolic disorders: Pathogenesis and therapeutic
   strategies
SO LIFE SCIENCES
LA English
DT Review
DE Oxidative stress; Antioxidant; Metabolic disorders; Inflammation;
   Diabetes; Cardiovascular diseases; Insulin resistance; Carcinogenesis;
   Phytochemicals
ID FORKHEAD TRANSCRIPTION FACTORS; CYCLIN-DEPENDENT KINASE-4; BETA-CELL
   PROLIFERATION; REACTIVE OXYGEN; ADIPOCYTE DIFFERENTIATION; HISTONE
   MODIFICATIONS; DIABETES-MELLITUS; NITRIC-OXIDE; VASCULAR COMPLICATIONS;
   INSULIN-RESISTANCE
AB Increased body weight and metabolic disorder including insulin resistance, type 2 diabetes and cardiovascular complications together constitute metabolic syndrome. The pathogenesis of metabolic syndrome involves multitude of factors. A number of studies however indicate, with some conformity, that oxidative stress along with chronic inflammatory condition pave the way for the development of metabolic diseases. Oxidative stress, a state of lost balance between the oxidative and anti-oxidative systems of the cells and tissues, results in the over production of oxidative free radicals and reactive oxygen species (ROS). Excessive ROS generated could attack the cellular proteins, lipids and nucleic acids leading to cellular dysfunction including loss of energy metabolism, altered cell signalling and cell cycle control, genetic mutations, altered cellular transport mechanisms and overall decreased biological activity, immune activation and inflammation. In addition, nutritional stress such as that caused by high fat high carbohydrate diet also promotes oxidative stress as evident by increased lipid peroxidation products, protein carbonylation, and decreased antioxidant system and reduced glutathione (GSH) levels. These changes lead to initiation of pathogenicmilieu and development of several chronic diseases. Studies suggest that in obese person oxidative stress and chronic inflammation are the important underlying factors that lead to development of pathologies such as carcinogenesis, obesity, diabetes, and cardiovascular diseases through altered cellular and nuclear mechanisms, including impaired DNA damage repair and cell cycle regulation. Here wediscuss the aspects ofmetabolic disorders-induced oxidative stress inmajor pathological conditions and strategies for their prevention and therapy. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Rani, Vibha] JayPee Inst Informat Technol, Dept Biotechnol, A-10,Sect 62, Noida 201307, UP, India.
   [Deep, Gagan] Univ Colorado Denver, Skaggs Sch Pharm & Pharmaceut Sci, 12850 E Montview Blvd, Aurora, CO 80045 USA.
   [Singh, Rakesh K.] Florida State Univ, Coll Med, Translat Sci Lab, 1115 West Call St, Tallahassee, FL 32306 USA.
   [Palle, Komaraiah] USA Mitchell Canc Inst, Dept Oncol Sci, 1660 Spring Hill Ave, Mobile, AL 36604 USA.
   [Yadav, Umesh C. S.] Cent Univ Gujarat, Sch Life Sci, Metab Disorder & Inflammatory Pathol Lab, Sect 30, Gandhinagar 382030, India.
C3 Jaypee Institute of Information Technology (JIIT); Children's Hospital
   Colorado; University of Colorado System; University of Colorado Anschutz
   Medical Campus; State University System of Florida; Florida State
   University; Central University of Gujarat
RP Yadav, UCS (corresponding author), Cent Univ Gujarat, Sch Life Sci, Metab Disorder & Inflammatory Pathol Lab, Sect 30, Gandhinagar 382030, India.
EM vibha.rani@jiit.ac.in; Gagan.Deep@ucdenver.edu;
   rakesh.singh@med.fsu.edu; kpalle@health.southalabama.edu;
   umeshyadav@cug.ac.in
RI Deep, Gagan/H-1853-2012; Singh, Prof R K/GPG-0335-2022
FU Department of Science and Technology (DST), Government of India
   [SR/S2/RJN-102/2012]; Department of Biotechnology (DBT), Government of
   India [BT/PR3978/17/766/2011]; Abraham A. Mitchell Cancer Research
   Scholar Endowment Grant
FX Award of Ramanujan Fellowship from Department of Science and Technology
   (DST), Government of India SR/S2/RJN-102/2012 (UCSY); fund support from
   Department of Biotechnology (DBT), Government of India
   BT/PR3978/17/766/2011 (VR) and Abraham A. Mitchell Cancer Research
   Scholar Endowment Grant (KP) are acknowledged. Assistance of Drs.
   Chinnadurai Mani and Neha Atale for assisting with preparation of the
   manuscript is also acknowledged.
CR Afanas'ev I, 2014, AGING DIS, V5, P52, DOI 10.14336/AD.2014.050052
   Al-Aubaidy HA, 2011, EUR J ENDOCRINOL, V164, P899, DOI 10.1530/EJE-11-0053
   [Anonymous], 2013, J. Pharmacogn Phytochem, DOI [10.1007/978-1-4614-3912-7_4, DOI 10.1007/978-1-4614-3912-7_4]
   Aprahamian TR, 2011, INT J INFLAMM, V2011, DOI 10.4061/2011/376909
   Arora T, 2013, NUTRITION, V29, P591, DOI 10.1016/j.nut.2012.07.017
   Atale N, 2013, CARDIOVASC TOXICOL, V13, P278, DOI 10.1007/s12012-013-9207-1
   Balaban RS, 2005, CELL, V120, P483, DOI 10.1016/j.cell.2005.02.001
   Beckman JS, 1996, AM J PHYSIOL-CELL PH, V271, pC1424
   Belda-Iniesta C, 2011, CLIN TRANSL ONCOL, V13, P363, DOI 10.1007/s12094-011-0669-y
   Belot MP, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0068093
   Bigornia SJ, 2010, OBESITY, V18, P754, DOI 10.1038/oby.2009.482
   Bitar MS, 2005, EUR J PHARMACOL, V511, P53, DOI 10.1016/j.ejphar.2005.01.014
   Bjelakovic G, 2012, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD007176.pub2, 10.1590/1516-3180.20151332T1]
   Boden G, 1997, DIABETES, V46, P3, DOI 10.2337/diabetes.46.1.3
   Bondia-Pons I, 2012, J PHYSIOL BIOCHEM, V68, P701, DOI 10.1007/s13105-012-0154-2
   Braun S, 2011, INT J BIOL SCI, V7, P1003, DOI 10.7150/ijbs.7.1003
   Bryan S, 2013, CAN J PHYSIOL PHARM, V91, P22, DOI 10.1139/cjpp-2012-0295
   Burch PM, 2005, ANTIOXID REDOX SIGN, V7, P741, DOI 10.1089/ars.2005.7.741
   Cairns RA, 2013, CANCER DISCOV, V3, P730, DOI 10.1158/2159-8290.CD-13-0083
   Calder PC, 2011, BRIT J NUTR, V106, pS1, DOI 10.1017/S0007114511005460
   Calle EE, 2003, NEW ENGL J MED, V348, P1625, DOI 10.1056/NEJMoa021423
   Campbell MJ, 2013, ADV EXP MED BIOL, V754, P81, DOI 10.1007/978-1-4419-9967-2_4
   CERIELLO A, 1993, DIABETOLOGIA, V36, P265, DOI 10.1007/BF00399961
   Chen J., 2012, TRANSL GASTROINTEST, V1, P243, DOI DOI 10.3978/J.ISSN.2224-4778.2012.09.04
   Chetboun M, 2012, J CELL BIOCHEM, V113, P1966, DOI 10.1002/jcb.24065
   Chrysohoou C, 2007, NUTR METAB CARDIOVAS, V17, P590, DOI 10.1016/j.numecd.2006.05.007
   Codoñer-Franch P, 2012, NUTR METAB CARDIOVAS, V22, P237, DOI 10.1016/j.numecd.2010.06.002
   Cohen B, 1996, SCIENCE, V274, P1185, DOI 10.1126/science.274.5290.1185
   Cozar-Castellano I, 2004, DIABETES, V53, P149, DOI 10.2337/diabetes.53.1.149
   Dahl C, 2011, CLIN CHIM ACTA, V412, P831, DOI 10.1016/j.cca.2011.02.013
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   Dandona P, 2010, EXP MOL MED, V42, P245, DOI 10.3858/emm.2010.42.4.033
   Davì G, 1999, CIRCULATION, V99, P224
   de Mattos AM, 2012, THER APHER DIAL, V16, P68, DOI 10.1111/j.1744-9987.2011.01009.x
   De Pergola G, 2013, J OBES, V2013, DOI 10.1155/2013/291546
   Dröse S, 2012, ADV EXP MED BIOL, V748, P145, DOI 10.1007/978-1-4614-3573-0_6
   Dupont C, 2013, ASIAN J ANDROL, V15, P622, DOI 10.1038/aja.2013.65
   Eddouks M, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/142087
   Endemann DH, 2004, CURR HYPERTENS REP, V6, P85, DOI 10.1007/s11906-004-0081-x
   Fajas L, 2003, ANN MED, V35, P79, DOI 10.1080/07853890310009999
   Fajas L, 2002, DEV CELL, V3, P39, DOI 10.1016/S1534-5807(02)00190-9
   Fatrai S, 2006, DIABETES, V55, P318, DOI 10.2337/diabetes.55.02.06.db05-0757
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Fiaschi-Taesch NM, 2013, DIABETES, V62, P2450, DOI 10.2337/db12-0777
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Fortuño A, 2006, DIABETES, V55, P209, DOI 10.2337/diabetes.55.1.209
   Fu XD, 2007, GYNECOL ENDOCRINOL, V23, P131, DOI 10.1080/09513590601181457
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Furukawa-Hibi Y, 2002, J BIOL CHEM, V277, P26729, DOI 10.1074/jbc.C200256200
   Gallagher EJ, 2010, ENDOCR PRACT, V16, P864, DOI 10.4158/EP10098.RA
   Gallagher EJ, 2010, PRINCIPLES OF DIABETES MELLITUS, SECOND EDITION, P579, DOI 10.1007/978-0-387-09841-8_36
   Gandhi G., 2012, Res. J. Biol, V2, P37
   Giacco F, 2010, CIRC RES, V107, P1058, DOI 10.1161/CIRCRESAHA.110.223545
   González-Castejón M, 2011, PHARMACOL RES, V64, P438, DOI 10.1016/j.phrs.2011.07.004
   Gorrini C, 2013, NAT REV DRUG DISCOV, V12, P931, DOI 10.1038/nrd4002
   Grattagliano I, 2008, J NUTR BIOCHEM, V19, P491, DOI 10.1016/j.jnutbio.2007.06.011
   Grek CL, 2010, CURR OPIN PHARMACOL, V10, P362, DOI 10.1016/j.coph.2010.05.003
   Guppy A, 2011, FUTURE ONCOL, V7, P727, DOI [10.2217/fon.11.49, 10.2217/FON.11.49]
   Hall E, 2013, BMC MED GENET, V14, DOI 10.1186/1471-2350-14-76
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   He TR, 2003, AM J PHYSIOL-HEART C, V285, pH804, DOI 10.1152/ajpheart.01080.2002
   Ho E, 2013, REDOX BIOL, V1, P483, DOI 10.1016/j.redox.2013.07.006
   Holvoet P, 2004, DIABETES, V53, P1068, DOI 10.2337/diabetes.53.4.1068
   Holvoet P, 2008, Verh K Acad Geneeskd Belg, V70, P193
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Huang PL, 2005, CIRC RES, V96, P1129, DOI 10.1161/01.RES.0000170705.56583.45
   Hutcheson Rebecca, 2012, Exp Diabetes Res, V2012, P271028, DOI 10.1155/2012/271028
   Ilkun O, 2013, CURR PHARM DESIGN, V19, P4806, DOI 10.2174/1381612811319270003
   Inoue N, 2008, J BIOL CHEM, V283, P21220, DOI 10.1074/jbc.M801824200
   Jain A, 2015, CHEM-BIOL INTERACT, V225, P54, DOI 10.1016/j.cbi.2014.11.017
   Jiang F, 2011, REDOX REP, V16, P223, DOI 10.1179/174329211X13049558293713
   Kanda Y, 2011, LIFE SCI, V89, P250, DOI 10.1016/j.lfs.2011.06.007
   Karaouzene N, 2011, NUTR METAB CARDIOVAS, V21, P792, DOI 10.1016/j.numecd.2010.02.007
   Karasu Cimen, 2010, Open Cardiovasc Med J, V4, P240, DOI 10.2174/1874192401004010240
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Khandrika L, 2009, CANCER LETT, V282, P125, DOI 10.1016/j.canlet.2008.12.011
   Kim SY, 2015, BIOMOL THER, V23, P99, DOI 10.4062/biomolther.2015.013
   Kim YH, 2015, INTEST RES, V13, P145, DOI 10.5217/ir.2015.13.2.145
   Kohli S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076519
   Kramer HF, 2007, J APPL PHYSIOL, V103, P388, DOI 10.1152/japplphysiol.00085.2007
   Kumar B, 2008, CANCER RES, V68, P1777, DOI 10.1158/0008-5472.CAN-07-5259
   Kunitomo M, 2008, J PHARMACOL SCI, V107, P128, DOI 10.1254/jphs.FP0072365
   Lee H, 2009, J BIOL CHEM, V284, P10601, DOI 10.1074/jbc.M808742200
   Lee JH, 2012, DIGEST LIVER DIS, V44, P1042, DOI 10.1016/j.dld.2012.06.007
   Lenzen S, 1996, FREE RADICAL BIO MED, V20, P463, DOI 10.1016/0891-5849(96)02051-5
   Li HT, 2015, INT J CLIN EXP MED, V8, P11549
   Li PF, 1997, CIRCULATION, V96, P3602
   Lin J, 2009, JNCI-J NATL CANCER I, V101, P14, DOI 10.1093/jnci/djn438
   Ling C, 2008, DIABETOLOGIA, V51, P615, DOI 10.1007/s00125-007-0916-5
   Lonardo E, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076518
   Ma YL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0053916
   Macleod KF, 2008, NAT REV CANCER, V8, P769, DOI 10.1038/nrc2504
   Malandrino MI, 2015, AM J PHYSIOL-ENDOC M, V308, pE756, DOI 10.1152/ajpendo.00362.2014
   MARES J, 1993, DIABETES METAB, V19, P315
   Martindale JL, 2002, J CELL PHYSIOL, V192, P1, DOI 10.1002/jcp.10119
   Mathew OP, 2014, PHARMACEUTICALS, V7, P1008, DOI 10.3390/ph7111008
   Matoba S, 2006, SCIENCE, V312, P1650, DOI 10.1126/science.1126863
   Matsuzawa-Nagata N, 2008, METABOLISM, V57, P1071, DOI 10.1016/j.metabol.2008.03.010
   McNaughton D, 2013, CRIT PUBLIC HEALTH, V23, P274, DOI 10.1080/09581596.2013.766671
   Medema RH, 2000, NATURE, V404, P782, DOI 10.1038/35008115
   Mente A, 2009, ARCH INTERN MED, V169, P659, DOI 10.1001/archinternmed.2009.38
   Mesquita FS, 2010, BIOL REPROD, V82, P341, DOI 10.1095/biolreprod.108.075887
   Monks TJ, 2006, DRUG METAB REV, V38, P755, DOI 10.1080/03602530600959649
   Monteiro R, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/289645
   Murphy MP, 2009, BIOCHEM J, V417, P1, DOI 10.1042/BJ20081386
   Nakabeppu Y, 2014, INT J MOL SCI, V15, P12543, DOI 10.3390/ijms150712543
   Nakamura N, 2000, MOL CELL BIOL, V20, P8969, DOI 10.1128/MCB.20.23.8969-8982.2000
   Ndisang JF, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/506948
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Pandey KB, 2009, OXID MED CELL LONGEV, V2, P270, DOI 10.4161/oxim.2.5.9498
   Parasuraman Subramani, 2014, Pharmacogn Rev, V8, P73, DOI 10.4103/0973-7847.134229
   Paravicini TM, 2006, CARDIOVASC RES, V71, P247, DOI 10.1016/j.cardiores.2006.05.001
   Park S, 2015, EXP MOL MED, V47, DOI 10.1038/emm.2014.113
   Patel C, 2007, J CLIN ENDOCR METAB, V92, P4476, DOI 10.1210/jc.2007-0778
   Pechánová O, 2015, BRIT J PHARMACOL, V172, P1415, DOI 10.1111/bph.12960
   Provinciali N, 2015, EXPERT OPIN DRUG SAF, V14, P1573, DOI 10.1517/14740338.2015.1084289
   Qin L, 2014, J PHARMACOL SCI, V125, P283, DOI 10.1254/jphs.13239FP
   Quinn BJ, 2013, TRENDS ENDOCRIN MET, V24, P469, DOI 10.1016/j.tem.2013.05.004
   Rane SG, 1999, NAT GENET, V22, P44, DOI 10.1038/8751
   RAO GN, 1992, CIRC RES, V70, P593, DOI 10.1161/01.RES.70.3.593
   Reuter S, 2010, FREE RADICAL BIO MED, V49, P1603, DOI 10.1016/j.freeradbiomed.2010.09.006
   Richon VM, 1997, J BIOL CHEM, V272, P10117, DOI 10.1074/jbc.272.15.10117
   Rizos CV, 2013, EUR J PHARMACOL, V705, P96, DOI 10.1016/j.ejphar.2013.02.038
   Rysman E, 2010, CANCER RES, V70, P8117, DOI 10.1158/0008-5472.CAN-09-3871
   Savini I, 2013, INT J MOL SCI, V14, P10497, DOI 10.3390/ijms140510497
   Sawan C, 2010, ADV GENET, V70, P57, DOI [10.1016/B978-0-12-380866-0.60003-4, 10.1016/S0065-2660(10)70003-1]
   Scheele C, 2009, TRENDS ENDOCRIN MET, V20, P95, DOI 10.1016/j.tem.2008.12.002
   Schmidt M, 2002, MOL CELL BIOL, V22, P7842, DOI 10.1128/MCB.22.22.7842-7852.2002
   Schroeder K, 2009, ARTERIOSCL THROM VAS, V29, P239, DOI 10.1161/ATVBAHA.108.174219
   Sciacovelli M, 2014, METHOD ENZYMOL, V542, P1, DOI 10.1016/B978-0-12-416618-9.00001-7
   Shibata R, 2009, CIRC J, V73, P608, DOI 10.1253/circj.CJ-09-0057
   Shishehbor MH, 2003, JAMA-J AM MED ASSOC, V289, P1675, DOI 10.1001/jama.289.13.1675
   Shrotriya S, 2015, MOL CARCINOGEN, V54, P1734, DOI 10.1002/mc.22246
   Sies H, 2005, J NUTR, V135, P969, DOI 10.1093/jn/135.5.969
   Singh Raja B, 2002, Exp Clin Cardiol, V7, P40
   Sinha D., 2014, Int J Phytother Res, V4, P28
   Sofi F, 2010, AM J CLIN NUTR, V92, P1189, DOI 10.3945/ajcn.2010.29673
   SWENNE I, 1983, DIABETES, V32, P14, DOI 10.2337/diabetes.32.1.14
   Szczepaniak LS, 2003, MAGN RESON MED, V49, P417, DOI 10.1002/mrm.10372
   Tabatabaei-Malazy O, 2015, J DIABETES METAB DIS, V14, DOI 10.1186/s40200-015-0184-8
   Tormos KV, 2011, CELL METAB, V14, P537, DOI 10.1016/j.cmet.2011.08.007
   TOYOKUNI S, 1995, FEBS LETT, V358, P1, DOI 10.1016/0014-5793(94)01368-B
   Tyner SD, 2002, NATURE, V415, P45, DOI 10.1038/415045a
   van Kruijsdijk RCM, 2009, CANCER EPIDEM BIOMAR, V18, P2569, DOI 10.1158/1055-9965.EPI-09-0372
   Vousden KH, 2009, NAT REV CANCER, V9, P691, DOI 10.1038/nrc2715
   Wang WM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0120629
   Warolin J, 2014, PEDIATR OBES, V9, P43, DOI 10.1111/j.2047-6310.2012.00135.x
   WOITCZAK L, 1993, BIOCHIM BIOPHYS ACTA, V1183, P41, DOI 10.1016/0005-2728(93)90004-Y
   WOLFF SP, 1991, FREE RADICAL BIO MED, V10, P339, DOI 10.1016/0891-5849(91)90040-A
   Yadav UCS, 2015, CURR MOL MED, V15, P598, DOI 10.2174/1566524015666150831130954
   Yahagi N, 2004, J BIOL CHEM, V279, P20571, DOI 10.1074/jbc.M400884200
   Yamagishi S, 2012, BBA-GEN SUBJECTS, V1820, P663, DOI 10.1016/j.bbagen.2011.03.014
   Zelzer S, 2011, CLIN CHIM ACTA, V412, P1345, DOI 10.1016/j.cca.2011.03.031
NR 154
TC 839
Z9 909
U1 17
U2 403
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD MAR 1
PY 2016
VL 148
BP 183
EP 193
DI 10.1016/j.lfs.2016.02.002
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA DG0XM
UT WOS:000371789300023
PM 26851532
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Sanghez, V
   Razzoli, M
   Carobbio, S
   Campbell, M
   McCallum, J
   Cero, C
   Ceresini, G
   Cabassi, A
   Govoni, P
   Franceschini, P
   de Santis, V
   Gurney, A
   Ninkovic, I
   Parmigiani, S
   Palanza, P
   Vidal-Puig, A
   Bartolomucci, A
AF Sanghez, Valentina
   Razzoli, Maria
   Carobbio, Stefania
   Campbell, Mark
   McCallum, Jacob
   Cero, Cheryl
   Ceresini, Graziano
   Cabassi, Aderville
   Govoni, Paolo
   Franceschini, Paolo
   de Santis, Valentina
   Gurney, Allison
   Ninkovic, Ivana
   Parmigiani, Stefano
   Palanza, Paola
   Vidal-Puig, Antonio
   Bartolomucci, Alessandro
TI Psychosocial stress induces hyperphagia and exacerbates diet-induced
   insulin resistance and the manifestations of the Metabolic Syndrome
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Social stress; Dominance; Subiordination; Type 2 diabetes; Laptin;
   Adiponectin; Glucose tolerance test; Hyperphagia
ID CHRONIC SOCIAL STRESS; HIGH-FAT DIET; INDUCED OBESITY; VISCERAL OBESITY;
   LIFE EVENTS; FOOD-INTAKE; MALE-MICE; VULNERABILITY; DEFEAT; HEALTH
AB Stress and hypercaloric food are recognized risk factors for obesity, Metabolic Syndrome (MetS) and Type 2 Diabetes (T2D). Given the complexity of these metabolic processes and the unavailability of animal models, there is poor understanding of their underlying mechanisms. We established a model of chronic psychosocial stress in which subordinate mice are vulnerable to weight gain while dominant mice are resilient. Subordinate mice fed a standard diet showed marked hyperphagia, high leptin, low adiponectin, and dyslipidemia. Despite these molecular signatures of MetS and T2D, subordinate mice fed a standard diet were still euglycemic. We hypothesized that stress predisposes subordinate mice to develop T2D when synergizing with other risk factors. High fat diet aggravated dyslipidemia and the MetS thus causing a pre-diabetes-like state in subordinate mice. Contrary to subordinates, dominant mice were fully protected from stress-induced metabolic disorders when fed both a standard- and a high fat-diet. Dominant mice showed a hyperphagic response that was similar to subordinate but, unlike subordinates, showed a significant increase in VO2, VCO2, and respiratory exchange ratio when compared to control mice. Overall, we demonstrated a robust stress- and social status-dependent effect on the development of MetS and T2D and provided insights on the physiological mechanisms. Our results are reminiscent of the effect of the individual socioeconomic status on human health and provide an animal model to study the underlying molecular mechanisms. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Sanghez, Valentina; Razzoli, Maria; McCallum, Jacob; Cero, Cheryl; Gurney, Allison; Ninkovic, Ivana; Bartolomucci, Alessandro] Univ Minnesota, Dept Integrat Biol & Physiol, Minneapolis, MN 55455 USA.
   [Sanghez, Valentina; Franceschini, Paolo; de Santis, Valentina; Parmigiani, Stefano; Palanza, Paola] Univ Parma, Dept Neurosci, I-43100 Parma, Italy.
   [Carobbio, Stefania; Campbell, Mark; Vidal-Puig, Antonio] Univ Cambridge, Addenbrookes Hosp, Metab Res Labs, Cambridge CB2 2QQ, England.
   [Ceresini, Graziano; Cabassi, Aderville] Univ Parma, Dept Clin & Expt Med, I-43100 Parma, Italy.
   [Govoni, Paolo] Univ Parma, Dept Biomed Sci, I-43100 Parma, Italy.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Parma; University of Cambridge; Cambridge University
   Hospitals NHS Foundation Trust; Addenbrooke's Hospital; University of
   Parma; University Hospital of Parma; University of Parma
RP Bartolomucci, A (corresponding author), Univ Minnesota, Dept Integrat Biol & Physiol, Minneapolis, MN 55455 USA.
EM abartolo@umn.edu
RI Cero, Cheryl/JVZ-0936-2024; Bartolomucci, Alessandro/MFI-6219-2025;
   carobbio, stefania/E-7095-2018
OI Bartolomucci, Alessandro/0000-0001-6439-8829; PARMIGIANI,
   STEFANO/0000-0002-6658-2029; Sanghez, Valentina/0000-0002-4131-7480;
   Vidal-Puig, Antonio/0000-0003-4220-9577; RAZZOLI,
   Maria/0000-0001-5911-4633; Cero, Cheryl/0000-0003-0513-8669
FU University of Parma; MMF; UofMN Medical School; MRC; MRC DU; Cambridge
   Phenomics Centre; MRC [MC_UU_12012/2, G0600717, MC_G0802535, G0802051]
   Funding Source: UKRI
FX This work was supported in part by University of Parma, MMF, and UofMN
   Medical School to AB; MRC Program grant, MRC DU and Cambridge Phenomics
   Centre to TVP. Authors wish to thanks the Imaging Center, University of
   Minnesota, William Engeland and Carley Karsten, University of Minnesota,
   and Sergio Rodriguez Cuenca, University of Cambridge for technical
   assistance and Elizabeth Seaquist, University of Minnesota, for critical
   reading of an early version of this manuscript. Authors declare no
   conflict of interest.
CR Aldinger KA, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004729
   Bartolomucci A, 2001, PHYSIOL BEHAV, V73, P401, DOI 10.1016/S0031-9384(01)00453-X
   Bartolomucci A, 2005, NEUROSCI BIOBEHAV R, V29, P67, DOI 10.1016/j.neubiorev.2004.06.009
   Bartolomucci A, 2004, PSYCHONEUROENDOCRINO, V29, P899, DOI 10.1016/j.psyneuen.2003.08.003
   Bartolomucci A, 2007, FRONT NEUROENDOCRIN, V28, P28, DOI 10.1016/j.yfrne.2007.02.001
   Bartolomucci A, 2010, DIS MODEL MECH, V3, P459, DOI 10.1242/dmm.004614
   Bartolomucci A, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004331
   Björntorp P, 2000, BRIT J NUTR, V83, pS49, DOI 10.1017/S0007114500000957
   Bruning JC, 1997, CELL, V88, P561, DOI 10.1016/S0092-8674(00)81896-6
   Brunner E, 2007, PLOS BIOL, V5, P2449, DOI 10.1371/journal.pbio.0050267
   Cannon WB., 1929, Bodily changes in pain, hunger, fear, and rage, V28, P960
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Chaouloff F., 2013, CELL TISSUE IN PRESS
   Chuang JC, 2011, J CLIN INVEST, V121, P2684, DOI 10.1172/JCI57660
   Chuang JC, 2010, BIOL PSYCHIAT, V67, P1075, DOI 10.1016/j.biopsych.2009.12.003
   Chuang JC, 2010, J LIPID RES, V51, P1344, DOI 10.1194/jlr.M002196
   Dadomo H, 2011, PROG NEURO-PSYCHOPH, V35, P1461, DOI 10.1016/j.pnpbp.2010.11.016
   Dallman MF, 2010, TRENDS ENDOCRIN MET, V21, P159, DOI 10.1016/j.tem.2009.10.004
   DALLMAN MF, 1993, FRONT NEUROENDOCRIN, V14, P303, DOI 10.1006/frne.1993.1010
   Dubreucq S, 2012, NEUROSCIENCE, V204, P230, DOI 10.1016/j.neuroscience.2011.08.049
   Finger BC, 2011, NEUROSCIENCE, V192, P351, DOI 10.1016/j.neuroscience.2011.06.072
   Finger BC, 2012, PSYCHONEUROENDOCRINO, V37, P729, DOI 10.1016/j.psyneuen.2011.06.015
   Fisher JP, 2009, AUTON NEUROSCI-BASIC, V148, P5, DOI 10.1016/j.autneu.2009.02.003
   Foster MT, 2006, AM J PHYSIOL-REG I, V290, pR1284, DOI 10.1152/ajpregu.00437.2005
   Gesquiere LR, 2011, SCIENCE, V333, P357, DOI 10.1126/science.1207120
   KAHN CR, 1994, DIABETES, V43, P1066, DOI 10.2337/diab.43.8.1066
   Koolhaas JM, 2011, NEUROSCI BIOBEHAV R, V35, P1291, DOI 10.1016/j.neubiorev.2011.02.003
   Kuo LE, 2007, NAT MED, V13, P803, DOI 10.1038/nm1611
   Kyrou I, 2006, ANN NY ACAD SCI, V1083, P77, DOI 10.1196/annals.1367.008
   Leiter EH, 2009, METHODS MOL BIOL, V560, P1, DOI 10.1007/978-1-59745-448-3_1
   Lewis GF, 2002, ENDOCR REV, V23, P201, DOI 10.1210/er.23.2.201
   Mackenbach JP, 1997, LANCET, V349, P1655, DOI 10.1016/S0140-6736(96)07226-1
   MARTIN BC, 1992, LANCET, V340, P925, DOI 10.1016/0140-6736(92)92814-V
   McEwen BS, 2002, EUR HEART J, V23, P1727, DOI 10.1053/euhj.2002.3283
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   Moles A, 2006, PSYCHONEUROENDOCRINO, V31, P623, DOI 10.1016/j.psyneuen.2006.01.004
   Mooy JM, 2000, DIABETES CARE, V23, P197, DOI 10.2337/diacare.23.2.197
   Patterson ZR, 2013, ENDOCRINOLOGY, V154, P1080, DOI 10.1210/en.2012-1834
   Räikkönen K, 2007, DIABETES CARE, V30, P872, DOI 10.2337/dc06-1857
   Razzoli M., 2013, WILEY BOOK IN PRESS
   Razzoli M, 2011, PHARMACOL BIOCHEM BE, V97, P566, DOI 10.1016/j.pbb.2010.09.010
   Sapolsky RM, 2005, SCIENCE, V308, P648, DOI 10.1126/science.1106477
   Sapolsky RM, 2000, ENDOCR REV, V21, P55, DOI 10.1210/er.21.1.55
   Schmidt MV, 2009, STRESS, V12, P89, DOI 10.1080/10253890802049343
   Scott KA, 2012, CURR OBES REP, V1, DOI 10.1007/s13679-011-0006-3
   Shively CA, 2009, OBESITY, V17, P1513, DOI 10.1038/oby.2009.74
   Shonkoff JP, 2009, JAMA-J AM MED ASSOC, V301, P2252, DOI 10.1001/jama.2009.754
   Shpilberg Y, 2012, DIS MODEL MECH, V5, P671, DOI 10.1242/dmm.008912
   Singewald GM, 2009, STRESS, V12, P58, DOI 10.1080/10253890802042082
   Singh-Manoux A, 2005, PSYCHOSOM MED, V67, P855, DOI 10.1097/01.psy.0000188434.52941.a0
   Stumvoll M, 2005, LANCET, V365, P1333, DOI 10.1016/S0140-6736(05)61032-X
   Sun B, 2012, DIABETES, V61, P2833, DOI 10.2337/db11-0957
   Surwit Richard S., 1993, Annals of Behavioral Medicine, V15, P227
   Tamashiro KLK, 2007, AM J PHYSIOL-REG I, V293, pR1864, DOI 10.1152/ajpregu.00371.2007
   Taniguchi CM, 2006, NAT REV MOL CELL BIO, V7, P85, DOI 10.1038/nrm1837
   Tesfaye N, 2010, ANN NY ACAD SCI, V1212, P12, DOI 10.1111/j.1749-6632.2010.05820.x
   Ulrich-Lai YM, 2006, AM J PHYSIOL-REG I, V290, pR1128, DOI 10.1152/ajpregu.00042.2003
   Wilcox R.R., 1987, NEW STAT PROCEDURES
   Wilson ME, 2008, PHYSIOL BEHAV, V94, P586, DOI 10.1016/j.physbeh.2008.03.019
NR 59
TC 53
Z9 57
U1 0
U2 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD DEC
PY 2013
VL 38
IS 12
BP 2933
EP 2942
DI 10.1016/j.psyneuen.2013.07.022
PG 10
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA AA0YX
UT WOS:000330824400012
PM 24060458
DA 2025-06-11
ER

PT J
AU Fond, G
   Faugere, M
   Richieri, R
   Cermolacce, M
   Korchia, T
   Micoulaud-Franchi, JA
   de Verville, PLS
   Boyer, L
   Lançon, C
AF Fond, G.
   Faugere, M.
   Richieri, R.
   Cermolacce, M.
   Korchia, T.
   Micoulaud-Franchi, J. A.
   de Verville, P. L. Sunhary
   Boyer, L.
   Lancon, C.
TI Depressive symptoms and chronic peripheral inflammation are associated
   with impaired functional remission in schizophrenia independently of
   psychotic remissionl
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Psychiatry; Schizophrenia; Depression; Inflammation; Remission
ID C-REACTIVE PROTEIN; COGNITIVE IMPAIRMENT; DISORDERS; SCALE
AB Background: While psychotic remission in schizophrenia (SZ) has been defined by consensus and associated with a rank of clinical predictive factors, there is a lack of data of factors associated with functional remission.
   Objectives: To identify clinical and biological factors associated with impaired functional remission in a non selected chronic stabilized SZ outpatients.
   Methods: This study was a cross-sectional study carried out on all admitted SZ stabilized outpatients in an academic daily care psychiatric hospital. Functional remission was defined by a global assessment of functioning score >61. Psychotic remission was defined according to international criteria. Depression was assessed with the Calgary Depression Rating scale for Schizophrenia. Sociodemographic variables, tobacco status, clozapine treatment and obesity were reported. Chronic peripheral inflammation was defined by a highly sensitive C reactive protein serum level >3 mg/L and metabolic syndrome according to international recommendations.
   Results: 273 patients were included, among them 51 (18.7%) were classified in the functional remission group. In the multivariate analysis, higher rate of functional remission was associated with psychotic remission (adjusted Odd ratio = 18.2, p <0.001), lower depressive symptoms (aOR=0.8, p = 0.018) and lower peripheral inflammation (aOR=0.4, p = 0.046). No association of functional remission with age, gender, illness duration, second generation antipsychotics, clozapine treatment, tobacco smoking, obesity or metabolic syndrome has been found.
   Conclusion: Depressive symptoms and chronic peripheral inflammation are associated with impaired functional remission in SZ independently of psychotic remission. Future intervention studies should determine if improving depressive symptoms and chronic peripheral inflammation may improve SZ patients reaching functional remission.
C1 [Fond, G.; Faugere, M.; Cermolacce, M.; Korchia, T.; de Verville, P. L. Sunhary; Boyer, L.; Lancon, C.] Hop Univ Marseille, Dept Psychiat, F-13005 Marseille, France.
   [Fond, G.; Faugere, M.; Richieri, R.; de Verville, P. L. Sunhary; Boyer, L.; Lancon, C.] CEReSS Hlth Serv Res & Qual Life Ctr, EA 3279, 27 Blvd Jean Moulin, F-13005 Marseille, France.
   [Micoulaud-Franchi, J. A.] Univ Bordeaux, CHU Pellegrin, USR CNRS SANPSY 3413, Bordeaux, France.
C3 Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille;
   Aix-Marseille Universite; Centre National de la Recherche Scientifique
   (CNRS); CNRS - National Institute for Biology (INSB); CHU Bordeaux;
   Universite de Bordeaux
RP Fond, G (corresponding author), Aix Marseille Univ, EA 3279, CEReSS Ctr Etud & Rech Serv Sante & Qualite Vie, Fac Med,Sect Timone,AP HM, 27 Blvd Jean Moulin, F-13005 Marseille, France.
EM guillaume.fond@ap-hm.fr
RI Faugere, Melanie/JCP-3459-2023; richieri, raphaelle/E-4707-2015; Fond,
   Guillaume/D-7646-2011; Boyer, Laurent/E-5728-2016
OI Faugere, Melanie/0000-0001-5567-8650; Korchia, Theo/0000-0002-6392-9322;
   RICHIERI, Raphaelle/0000-0002-3901-7016; Boyer,
   Laurent/0000-0003-1229-6622
FU Hopitaux Universitaires de Marseille (HUM)
FX This study was supported by the Hopitaux Universitaires de Marseille
   (HUM).
CR ADDINGTON D, 1992, SCHIZOPHR RES, V6, P201, DOI 10.1016/0920-9964(92)90003-N
   ADDINGTON D, 1993, BRIT J PSYCHIAT, V163, P39, DOI 10.1192/S0007125000292581
   AlAqeel B, 2012, HARVARD REV PSYCHIAT, V20, P281, DOI 10.3109/10673229.2012.747804
   Andreasen NC, 2005, AM J PSYCHIAT, V162, P441, DOI 10.1176/appi.ajp.162.3.441
   Andrianarisoa M, 2017, SCHIZOPHR RES, V185, P173, DOI 10.1016/j.schres.2016.12.021
   Bender R, 2001, J CLIN EPIDEMIOL, V54, P343, DOI 10.1016/S0895-4356(00)00314-0
   Bulzacka E, 2016, SCHIZOPHRENIA BULL, V42, P1290, DOI 10.1093/schbul/sbw029
   Cho M, 2019, AUST NZ J PSYCHIAT, V53, P742, DOI 10.1177/0004867419835028
   Dazzan P, 2020, PSYCHOL MED, V50, P1452, DOI 10.1017/S0033291719001399
   Dubreucq J, 2019, EUR ARCH PSY CLIN N, V269, P599, DOI 10.1007/s00406-019-01001-4
   Eisenberger NI, 2020, WORLD PSYCHIATRY, V19, P109, DOI 10.1002/wps.20724
   Firth J, 2018, SCHIZOPHRENIA BULL, V44, P1275, DOI 10.1093/schbul/sbx162
   Fond G, 2019, EUR ARCH PSY CLIN N, V269, P985, DOI 10.1007/s00406-018-0908-0
   Fond G, 2018, SCHIZOPHR RES, V195, P529, DOI 10.1016/j.schres.2017.08.058
   Fond G, 2017, EUR ARCH PSY CLIN N, V267, P465, DOI 10.1007/s00406-017-0771-4
   Fond G, 2016, PSYCHOPHARMACOLOGY, V233, P571, DOI 10.1007/s00213-015-4167-8
   Fond G, 2014, ACTA PSYCHIAT SCAND, V129, P163, DOI 10.1111/acps.12211
   Fond G, 2020, J AFFECT DISORDERS, V265, P567, DOI 10.1016/j.jad.2019.11.092
   Fond G, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00392
   Fond G, 2018, BRIT J PSYCHIAT, V213, P464, DOI 10.1192/bjp.2018.87
   Godin O, 2015, SCHIZOPHR RES, V168, P388, DOI 10.1016/j.schres.2015.07.047
   Gorwood P, 2019, PSYCHIAT RES, V281, DOI 10.1016/j.psychres.2019.112560
   Green MF, 2016, J CLIN PSYCHIAT, V77, P8, DOI 10.4088/JCP.14074su1c.02
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Haddad PM, 2018, THER ADV PSYCHOPHARM, V8, P303, DOI 10.1177/2045125318781475
   KAY SR, 1986, BRIT J PSYCHIAT, V149, P439, DOI 10.1192/bjp.149.4.439
   Lançon C, 2000, SCHIZOPHR RES, V42, P231, DOI 10.1016/S0920-9964(99)00129-2
   Lassale C, 2019, MOL PSYCHIATR, V24, P965, DOI 10.1038/s41380-018-0237-8
   Legleye S, 2018, INT J METH PSYCH RES, V27, DOI 10.1002/mpr.1597
   Mallet J, 2019, EUR ARCH PSY CLIN N, V269, P449, DOI 10.1007/s00406-018-0873-7
   McGinty J, 2020, SCHIZOPHR RES, V218, P14, DOI 10.1016/j.schres.2019.12.011
   McGrath J, 2011, SCHIZOPHRENIA BULL, V37, P272, DOI 10.1093/schbul/sbq121
   Novick D, 2016, NEUROPSYCH DIS TREAT, V12, P2927, DOI 10.2147/NDT.S101151
   Olagunju AT, 2018, CNS DRUGS, V32, P1011, DOI 10.1007/s40263-018-0565-x
   Sarris J, 2016, AM J PSYCHIAT, V173, P575, DOI 10.1176/appi.ajp.2016.15091228
   SAUNDERS JB, 1993, ADDICTION, V88, P791, DOI 10.1111/j.1360-0443.1993.tb02093.x
   Wysokinski A, 2015, NORD J PSYCHIAT, V69, P346, DOI 10.3109/08039488.2014.984755
NR 37
TC 8
Z9 8
U1 0
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD FEB 1
PY 2021
VL 280
BP 267
EP 271
DI 10.1016/j.jad.2020.11.046
PN A
PG 5
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA PH8ZE
UT WOS:000600692600036
PM 33220563
DA 2025-06-11
ER

PT J
AU Patt, M
   Karkossa, I
   Krieg, L
   Massier, L
   Makki, K
   Tabei, S
   Karlas, T
   Dietrich, A
   Gericke, M
   Stumvoll, M
   Blüher, M
   von Bergen, M
   Schubert, K
   Kovacs, P
   Chakaroun, RM
AF Patt, Marie
   Karkossa, Isabel
   Krieg, Laura
   Massier, Lucas
   Makki, Kassem
   Tabei, Shirin
   Karlas, Thomas
   Dietrich, Arne
   Gericke, Martin
   Stumvoll, Michael
   Bluher, Matthias
   von Bergen, Martin
   Schubert, Kristin
   Kovacs, Peter
   Chakaroun, Rima M.
TI FGF21 and its underlying adipose tissue-liver axis inform
   cardiometabolic burden and improvement in obesity after metabolic
   surgery
SO EBIOMEDICINE
LA English
DT Article
ID GROWTH-FACTOR 21; Y GASTRIC BYPASS; BARIATRIC SURGERY; GENE-EXPRESSION;
   PLASMA FGF21; SUGAR INTAKE; WEIGHT-LOSS; GLUCOSE; REGULATOR; SECRETION
AB Background This research investigates the determinants of circulating FGF21 levels in a cohort reflecting metabolic disease progression, examining the associations of circulating FGF21 with morphology and function of adipose tissue (AT), and with metabolic adjustments following metabolic surgery. Methods We measured serum FGF21 in 678 individuals cross-sectionally and in 189 undergoing metabolic surgery longitudinally. Relationships between FGF21 levels, AT histology, transcriptomes and proteomes, cardiometabolic risk factors, and post-surgery metabolic adjustments were assessed using univariate and multivariate analyses, causal mediation analysis, and network integration of AT transcriptomes and proteomes. Findings FGF21 levels were linked to central adiposity, subclinical inflammation, insulin resistance, and cardiometabolic risk, and were driven by circulating leptin and liver enzymes. Higher FGF21 were linked with AT dysfunction reflected in fi bro-in fl ammatory and lipid dysmetabolism pathways. Specifically, visceral AT inflammation was tied to both FGF21 elevation and liver dysfunction. Post-surgery, FGF21 peaked transitorily at three months. Mediation analysis highlighted an underlying increased AT catabolic state with elevated free fatty acids (FFA), contributing to higher liver stress and FGF21 levels (total effect of free fatty acids on FGF21 levels: 0.38, p < 0.01; proportion mediation via liver 32%, p < 0.01). In line with this, histological AT fi brosis linked with less pronounced FGF21 responses and reduced fat loss post-surgery (FFA and visceral AT fi brosis: rho = - 0.31, p = 0.030; FFA and fat-mass loss: rho = 0.17, p = 0.020). Interpretation FGF21 reflects the liver's disproportionate metabolic stress response in both central adiposity and after metabolic surgery, with its dynamics reflecting an AT-liver crosstalk.
C1 [Massier, Lucas; Stumvoll, Michael; Bluher, Matthias; Kovacs, Peter; Chakaroun, Rima M.] Univ Leipzig, Med Dept Endocrinol Nephrol 3, Med Ctr, Leipzig, Germany.
   [Schubert, Kristin] UFZ, Helmholtz Ctr Environm Res, Dept Mol Syst Biol, Leipzig, Germany.
   Karolinska Inst, Dept Med H7, Stockholm, Sweden.
   Univ Lyon, INSA Lyon, INSERM, Lyon, France.
   [Tabei, Shirin] Univ Lubeck, Inst Endocrinol & Diabet, Lubeck, Germany.
   Univ Lubeck, Ctr Brain Behav & Metab CBBM, Lubeck, Germany.
   Univ Leipzig, Med Dept 2, Div Gastroenterol, Med Ctr, Leipzig, Germany.
   Univ Leipzig, Med Ctr, Dept Visceral Transplant Thorac & Vasc Surg, Leipzig, Germany.
   Univ Leipzig, Inst Anat, Leipzig, Germany.
   [Bluher, Matthias] Univ Leipzig, Helmholtz Inst Metab Obes & Vasc Res HI MAG, Helmholtz Zentrum Munchen, Leipzig, Germany.
   [Stumvoll, Michael; Bluher, Matthias] Univ Hosp Leipzig, Leipzig, Germany.
   [von Bergen, Martin] Univ Leipzig, Inst Biochem, Leipzig, Germany.
   [von Bergen, Martin] German Ctr Integrat Biodivers Res iDiv, Leipzig, Germany.
   [Kovacs, Peter] Deutsch Zent Diabetesforsch eV, Neuherberg, Germany.
   [Chakaroun, Rima M.] Univ Gothenburg, Dept Mol & Clin Med, Wallenberg Lab, Gothenburg, Sweden.
   [Chakaroun, Rima M.] Univ Gothenburg, Sahlgrenska Ctr Cardiovasc & Metab Res, Gothenburg, Sweden.
C3 Leipzig University; Helmholtz Association; Helmholtz Center for
   Environmental Research (UFZ); Karolinska Institutet; Institut National
   des Sciences Appliquees de Lyon - INSA Lyon; Institut National de la
   Sante et de la Recherche Medicale (Inserm); University of Lubeck;
   University of Lubeck; Leipzig University; Leipzig University; Leipzig
   University; Helmholtz Association; Helmholtz-Center Munich - German
   Research Center for Environmental Health; Leipzig University; Leipzig
   University; Leipzig University; German Research Foundation (DFG); German
   Centre for Integrative Biodiversity Research (iDiv); University of
   Gothenburg; University of Gothenburg
RP Chakaroun, RM (corresponding author), Univ Leipzig, Med Dept Endocrinol Nephrol 3, Med Ctr, Leipzig, Germany.
EM rima.chakaroun@wlab.gu.se
RI Gericke, Martin/AAI-8637-2020; Kovacs, Peter/KCK-1454-2024; Stumvoll,
   Michael/ABE-1121-2021; Massier, Lucas/AEE-9781-2022; Karkossa,
   Isabel/AAH-1809-2021; von Bergen, Martin/D-7960-2011; makki,
   kassem/HTN-0263-2023; Karlas, Thomas/I-1782-2019; Chakaroun,
   Rima/LGY-8314-2024; Schubert, Kristin/AAB-6438-2020
OI Karlas, Thomas/0000-0002-8109-8526
FU Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
   [209933838, CRC1382, 530364326]; Medical Faculty, University of Leipzig;
   Federal Ministry of Education and Research (BMBF) , Germany; European
   Union; Novo Nordisk Foundation;  [CRC 1052];  [FKZ: 01EO1501]; 
   [HEALTH-F4-2012-305312]
FX This work was supported by the Deutsche Forschungsgemeinschaft (DFG,
   German Research Foundation) through CRC 1052, project number 209933838,
   CRC1382 and a Walther-Benjamin Fellowship and by a junior research grant
   by the Medical Faculty, University of Leipzig, and by the Federal
   Ministry of Education and Research (BMBF) , Germany, FKZ: 01EO1501. Part
   of this work was supported by the European Union's Seventh Framework
   Program for research, technological development and demonstration under
   grant agreement HEALTH-F4-2012-305312 and by the CRC1382 and the Novo
   Nordisk Foundation and by the Deutsche Forschungsgemeinschaft (DFG,
   German Research foundation) project number 530364326.
CR Adams AC, 2013, MOL METAB, V2, P31, DOI 10.1016/j.molmet.2012.08.007
   [Anonymous], 2019, Diabetes Care, V42, pS13
   Benjamin EJ, 2019, CIRCULATION, V139, pE56, DOI [10.1161/CIR.0000000000000659, 10.1161/CIR.0000000000000746]
   Berglund ED, 2009, ENDOCRINOLOGY, V150, P4084, DOI 10.1210/en.2009-0221
   Berti L, 2015, MOL METAB, V4, P519, DOI 10.1016/j.molmet.2015.04.002
   Blühre M, 2009, EXP CLIN ENDOCR DIAB, V117, P241, DOI 10.1055/s-0029-1192044
   Busetto L, 2024, NAT MED, V30, P2395, DOI 10.1038/s41591-024-03095-3
   Cefalu WT, 2015, DIABETES CARE, V38, P1567, DOI 10.2337/dc15-1081
   Charles ED, 2019, OBESITY, V27, P41, DOI 10.1002/oby.22344
   Chavez AO, 2009, DIABETES CARE, V32, P1542, DOI 10.2337/dc09-0684
   Chen ZW, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.1089214
   Cheng R, 2021, MOL MED REP, V24, DOI 10.3892/mmr.2021.12417
   Corcelles R, 2016, OBES SURG, V26, P1794, DOI 10.1007/s11695-015-2022-y
   Crujeiras AB, 2017, INT J OBESITY, V41, P1570, DOI 10.1038/ijo.2017.138
   De Luca A, 2023, OBES SURG, V33, P2468, DOI 10.1007/s11695-023-06702-3
   DeBari MK, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21176030
   Debédat J, 2018, DIABETES CARE, V41, P2086, DOI 10.2337/dc18-0567
   Dushay J, 2010, GASTROENTEROLOGY, V139, P456, DOI 10.1053/j.gastro.2010.04.054
   Forslund SK, 2021, NATURE, V600, P500, DOI 10.1038/s41586-021-04177-9
   Frayling TM, 2018, CELL REP, V23, P327, DOI 10.1016/j.celrep.2018.03.070
   Geng LL, 2020, NAT REV ENDOCRINOL, V16, P654, DOI 10.1038/s41574-020-0386-0
   Gerhard GS, 2014, INT J OBESITY, V38, P371, DOI 10.1038/ijo.2013.152
   Gómez-Ambrosi J, 2012, INT J OBESITY, V36, P286, DOI 10.1038/ijo.2011.100
   Gómez-Ambrosi J, 2017, CLIN NUTR, V36, P861, DOI 10.1016/j.clnu.2016.04.027
   Hanipah ZN, 2020, ANNU REV MED, V71, P1, DOI 10.1146/annurev-med-053117-123246
   Hong ES, 2019, BMJ OPEN DIAB RES CA, V7, DOI 10.1136/bmjdrc-2019-000776
   Hosseinzadeh A, 2020, OBES SURG, V30, P4046, DOI 10.1007/s11695-020-04807-7
   Huang DW, 2009, NAT PROTOC, V4, P44, DOI 10.1038/nprot.2008.211
   Jansen PLM, 2011, DIGEST DIS, V29, P48, DOI 10.1159/000324128
   Jensen-Cody SO, 2020, CELL METAB, V32, P273, DOI 10.1016/j.cmet.2020.06.008
   Kersten S, 2014, MOL METAB, V3, P354, DOI 10.1016/j.molmet.2014.02.002
   Keuper M, 2020, EXP CLIN ENDOCR DIAB, V128, P752, DOI 10.1055/a-0879-2968
   Krieg L, 2022, GUT, V71, P2179, DOI 10.1136/gutjnl-2021-324603
   Kursa MB, 2010, J STAT SOFTW, V36, P1, DOI 10.18637/jss.v036.i11
   Lassen PB, 2017, J CLIN ENDOCR METAB, V102, P2443, DOI 10.1210/jc.2017-00138
   Lee S, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22041639
   Lee Y, 2014, CLIN ENDOCRINOL, V80, P57, DOI 10.1111/cen.12134
   Lips MA, 2014, CLIN ENDOCRINOL, V81, P862, DOI 10.1111/cen.12496
   Lundåsen T, 2007, BIOCHEM BIOPH RES CO, V360, P437, DOI 10.1016/j.bbrc.2007.06.068
   Machinal F, 1999, ENDOCRINOLOGY, V140, P1567, DOI 10.1210/en.140.4.1567
   Manca C, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124340
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Morrison CD, 2016, MOL METAB, V5, P1006, DOI 10.1016/j.molmet.2016.08.005
   Osorio-Conles O, 2021, J CLIN MED, V10, DOI 10.3390/jcm10235516
   Pereira RO, 2021, ELIFE, V10, DOI 10.7554/eLife.66519
   Pérez-Martí A, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600725
   Qi YF, 2016, J LIPID RES, V57, P767, DOI 10.1194/jlr.M060574
   Robin X, 2011, BMC BIOINFORMATICS, V12, DOI 10.1186/1471-2105-12-77
   Sanyal A, 2018, LANCET, V392, P2705, DOI 10.1016/S0140-6736(18)31785-9
   Sullivan AI, 2022, MOL METAB, V64, DOI 10.1016/j.molmet.2022.101564
   Tan BK, 2011, DIABETES, V60, P2758, DOI 10.2337/db11-0672
   Tingley D, 2014, J STAT SOFTW, V59
   Verger EO, 2017, J ACAD NUTR DIET, V117, P878, DOI 10.1016/j.jand.2016.10.030
   Vinales KL, 2019, DIABETES, V68, P318, DOI 10.2337/db18-0696
   von Holstein-Rathlou S, 2016, CELL METAB, V23, P335, DOI 10.1016/j.cmet.2015.12.003
   Zhang S, 2021, J INFLAMM RES, V14, P4915, DOI 10.2147/JIR.S327858
   Zhang X, 2008, DIABETES, V57, P1246, DOI 10.2337/db07-1476
NR 57
TC 0
Z9 0
U1 2
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2352-3964
J9 EBIOMEDICINE
JI EBioMedicine
PD DEC
PY 2024
VL 110
AR 105458
DI 10.1016/j.ebiom.2024.105458
EA NOV 2024
PG 16
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA O2O2N
UT WOS:001369580200001
PM 39608059
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Huber, M
   Heiduschka, P
   Ziemssen, F
   Bolbrinker, J
   Kreutz, R
AF Huber, Matthias
   Heiduschka, Peter
   Ziemssen, Focke
   Bolbrinker, Juliane
   Kreutz, Reinhold
TI Microangiopathy and visual deficits characterize the retinopathy of a
   spontaneously hypertensive rat model with type 2 diabetes and metabolic
   syndrome
SO HYPERTENSION RESEARCH
LA English
DT Article
DE electroretinography; histology; metabolic syndrome; rat; retina
ID ROD PHOTORECEPTOR DYSFUNCTION; DIETARY FLAXSEED MEAL; ANIMAL-MODEL;
   RETINAL ARTERIOLES; INSULIN-RESISTANCE; OXIDATIVE STRESS; MULLER CELLS;
   STREPTOZOTOCIN; COMPLICATIONS; NEPHROPATHY
AB Retinopathy has been increasing in prevalence as a consequence of type 2 diabetes and a cluster of coexisting risk factors characterized as the metabolic syndrome. However, the combined effects of these conditions on the retina are poorly understood. Therefore, we focused on the spontaneously hypertensive corpulent rat (SHR/N-cp), a model with type 2 diabetes, obesity and features of the metabolic syndrome to characterize retinal changes at a structural and functional level. SHR/N-cp males at 4 and 8 months of age were used in this study. Metabolic parameters and blood pressure were measured by standard methods. Morphology was investigated by histological techniques supplemented by nicotinamide adenine dinucleotide phosphate-diaphorase staining of whole mounts and fluorescein angiography to analyze the retinal vasculature. The in vivo function of the retina was examined by electroretinography (ERG). Obese SHR/N-cp rats were hypertensive and showed significant increases in body weight, serum levels of glucose, triglycerides, total cholesterol and urinary glucose excretion compared with lean controls (P<0.01 for each). Histology indicated an overall intact integrity of the retina and aspects of microangiopathy in obese SHR/N-cp rats. ERG revealed intact processing of light signals but significantly decreased amplitudes of b-waves for all (P<0.01) and of a-waves for some examined light intensities (P<0.05). Oscillatory potentials were significantly protracted (P<0.01), whereas amplitudes were not reduced. Microangiopathy and electroretinographic deficits combine to produce an early non-proliferative retinopathy phenotype in the obese SHR/N-cp rats. Thus, this model represents a valuable experimental tool to obtain further insights into the mechanisms of retinopathy in the context of obesity, type 2 diabetes and metabolic syndrome. Hypertension Research (2011) 34, 103-112; doi: 10.1038/hr.2010.168; published online 7 October 2010
C1 [Huber, Matthias; Bolbrinker, Juliane; Kreutz, Reinhold] Charite, Inst Clin Pharmacol & Toxicol, Charite Ctr Therapieforsch, D-10117 Berlin, Germany.
   [Heiduschka, Peter] Univ Tubingen, Dept Augenheilkunde, Univ Klinikums Tubingen, Sekt Expt Vitreoretinale Chirurg, Tubingen, Germany.
   [Ziemssen, Focke] Univ Tubingen, Ctr Ophthalmol, Univ Augenklin Tubingen, Tubingen, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Eberhard Karls
   University of Tubingen; Eberhard Karls University Hospital; Eberhard
   Karls University of Tubingen; Eberhard Karls University Hospital
RP Huber, M (corresponding author), Charite, Inst Clin Pharmacol & Toxicol, Charite Ctr Therapieforsch, CharitePl 1, D-10117 Berlin, Germany.
EM matthias.huber@charite.de
RI Kreutz, Reinhold/AEV-0507-2022; Ziemssen, Focke/B-9564-2009; Heiduschka,
   Peter/AAX-3882-2021
OI Bolbrinker, Juliane/0000-0002-0812-8549; Kreutz,
   Reinhold/0000-0002-4818-211X
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Anan F, 2009, HYPERTENS RES, V32, P299, DOI 10.1038/hr.2009.8
   Baleanu D, 2009, INVEST OPHTH VIS SCI, V50, P4351, DOI 10.1167/iovs.08-3266
   Bhathena SJ, 2003, J AM COLL NUTR, V22, P157, DOI 10.1080/07315724.2003.10719289
   Bhutto IA, 1997, OPHTHALMIC RES, V29, P12, DOI 10.1159/000267986
   BRESNICK GH, 1987, ARCH OPHTHALMOL-CHIC, V105, P810
   Bringmann A, 2006, PROG RETIN EYE RES, V25, P397, DOI 10.1016/j.preteyeres.2006.05.003
   Bringmann A, 2009, NEUROCHEM INT, V54, P143, DOI 10.1016/j.neuint.2008.10.014
   Bronson SK, 2003, J CLIN INVEST, V111, P1817, DOI 10.1172/JCI200318927
   Brownlee M, 2005, DIABETES, V54, P1615, DOI 10.2337/diabetes.54.6.1615
   Bui BV, 2003, DIABETOLOGIA, V46, P401, DOI 10.1007/s00125-003-1042-7
   Chakrabarti S, 1997, DIABETES RES CLIN PR, V37, P109, DOI 10.1016/S0168-8227(97)00057-0
   Cheung N, 2008, PROG RETIN EYE RES, V27, P161, DOI 10.1016/j.preteyeres.2007.12.001
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   COGAN DG, 1961, ARCH OPHTHALMOL-CHIC, V66, P366, DOI 10.1001/archopht.1961.00960010368014
   Cunha-Vaz J, 2005, PROG RETIN EYE RES, V24, P355, DOI 10.1016/j.preteyeres.2004.07.004
   Doi K, 1975, Nihon Naibunpi Gakkai Zasshi, V51, P129
   Frank RN, 2004, NEW ENGL J MED, V350, P48, DOI 10.1056/NEJMra021678
   Goto R, 2005, JPN J OPHTHALMOL, V49, P363, DOI 10.1007/s10384-004-0213-5
   Gross ML, 2004, LAB INVEST, V84, P452, DOI 10.1038/labinvest.3700052
   Hammes HP, 2005, HORM METAB RES, V37, pS39, DOI 10.1055/s-2005-861361
   Hammes HP, 2004, DIABETES, V53, P1104, DOI 10.2337/diabetes.53.4.1104
   HAMMES HP, 1993, INVEST OPHTH VIS SCI, V34, P2092
   Hancock HA, 2004, INVEST OPHTH VIS SCI, V45, P1002, DOI 10.1167/iovs.03-1080
   Havel PJ, 1998, AM J PHYSIOL-REG I, V274, pR1482, DOI 10.1152/ajpregu.1998.274.5.R1482
   Heckenlively JR., 1991, Principles and practice of clinical electrophysiology of vision
   Kakehashi A, 2006, DIABETES-METAB RES, V22, P455, DOI 10.1002/dmrr.638
   Kaur C, 2008, PROG RETIN EYE RES, V27, P622, DOI 10.1016/j.preteyeres.2008.09.003
   Kohzaki K, 2008, INVEST OPHTH VIS SCI, V49, P3595, DOI 10.1167/iovs.08-1679
   KOLETSKY S, 1973, EXP MOL PATHOL, V19, P53, DOI 10.1016/0014-4800(73)90040-3
   Kondo T, 2003, J CLIN INVEST, V111, P1835, DOI 10.1172/JCI200317455
   Kreutz R, 2000, J HYPERTENS, V18, P777, DOI 10.1097/00004872-200018060-00017
   Ktorza A, 1997, DIABETES METAB, V23, P38
   Layton CJ, 2007, GRAEF ARCH CLIN EXP, V245, P1335, DOI 10.1007/s00417-006-0506-0
   Li Q, 2003, GRAEF ARCH CLIN EXP, V241, P747, DOI 10.1007/s00417-003-0740-7
   MARETTE A, 1991, AM J PHYSIOL, V261, pE204, DOI 10.1152/ajpendo.1991.261.2.E204
   Matsubara H, 2006, JPN J OPHTHALMOL, V50, P211, DOI 10.1007/s10384-005-0315-8
   Matsui K, 2008, EXP ANIM TOKYO, V57, P111, DOI 10.1538/expanim.57.111
   Matsuura T, 2005, INT J TISSUE REACT, V27, P59
   MICHAELIS OE, 1986, AM J PATHOL, V123, P398
   Misra Anoop, 2003, Am J Cardiovasc Drugs, V3, P325, DOI 10.2165/00129784-200303050-00004
   Mori A, 2007, EUR J PHARMACOL, V570, P135, DOI 10.1016/j.ejphar.2007.05.052
   Nathan DM, 2005, NEW ENGL J MED, V353, P2643, DOI 10.1056/nejmoa052187
   Okuno T, 2008, DOC OPHTHALMOL, V117, P191, DOI 10.1007/s10633-008-9122-0
   Osborne NN, 2004, PROG RETIN EYE RES, V23, P91, DOI 10.1016/j.preteyeres.2003.12.001
   Phipps JA, 2004, INVEST OPHTH VIS SCI, V45, pU89
   Phipps JA, 2006, INVEST OPHTH VIS SCI, V47, P3187, DOI 10.1167/iovs.05-1493
   Pinto CC, 2007, FREE RADICAL RES, V41, P1151, DOI 10.1080/10715760701632816
   POLLEY EH, 1984, J NEUROSCI METH, V12, P57, DOI 10.1016/0165-0270(84)90048-7
   Reichenbach A, 2007, GRAEF ARCH CLIN EXP, V245, P627, DOI 10.1007/s00417-006-0516-y
   ROBISON WG, 1995, INVEST OPHTH VIS SCI, V36, pS173
   Rodriguez-Fontal M, 2009, CURR DIABETES REV, V5, P3, DOI 10.2174/157339909787314176
   Rossing Peter, 2006, Curr Diab Rep, V6, P479, DOI 10.1007/s11892-006-0083-y
   Shirao Y, 1998, PROG RETIN EYE RES, V17, P59, DOI 10.1016/S1350-9462(97)00005-0
   Silva KC, 2007, EXP EYE RES, V85, P123, DOI 10.1016/j.exer.2007.03.008
   Silva KC, 2007, CURR EYE RES, V32, P533, DOI 10.1080/02713680701435391
   Silva KC, 2009, DIABETES, V58, P1382, DOI 10.2337/db09-0166
   Stearne MR, 1998, BMJ-BRIT MED J, V317, P703
   Stratton IM, 2001, DIABETOLOGIA, V44, P156, DOI 10.1007/s001250051594
   Striffler JS, 1998, METABOLISM, V47, P1199, DOI 10.1016/S0026-0495(98)90323-7
   Velasque M T, 2001, Int J Exp Diabetes Res, V2, P217, DOI 10.1155/EDR.2001.217
   Velasquez MT, 2003, KIDNEY INT, V64, P2100, DOI 10.1046/j.1523-1755.2003.00329.x
   Wilkinson-Berka JL, 2008, THESCIENTIFICWORLDJO, V8, P98, DOI 10.1100/tsw.2008.25
   WuPeng XS, 1997, DIABETES, V46, P513, DOI 10.2337/diabetes.46.3.513
   Yagil C, 2005, DIABETES, V54, P1487, DOI 10.2337/diabetes.54.5.1487
NR 65
TC 7
Z9 7
U1 0
U2 3
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD JAN
PY 2011
VL 34
IS 1
BP 103
EP 112
DI 10.1038/hr.2010.168
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 702TP
UT WOS:000285919100021
PM 20927114
OA Bronze
DA 2025-06-11
ER

PT J
AU Uzunlulu, M
   Oguz, A
   Yorulmaz, E
AF Uzunlulu, Mchmet
   Oguz, Aytekin
   Yorulmaz, Elif
TI The effect of carvedilol on metabolic parameters in patients with
   metabolic syndrome
SO INTERNATIONAL HEART JOURNAL
LA English
DT Article
DE metabolic syndrome; hypertension; carvedilol; doxazosin; atenolol
ID ELEVATED OXIDATIVE STRESS; INSULIN SENSITIVITY; DIABETES-MELLITUS;
   SERUM-LIPIDS; HYPERTENSION; PARTICLES; BLOCKERS; ATENOLOL; GLUCOSE;
   OBESITY
AB The objective of the present study was to explore the effect of carvedilol treatment on metabolic parameters in patients with metabolic syndrome. A total of 77 patients >= 20 years of age (59 females, 18 mates, mean age, 52.3 +/- 10.3) with stage 1 hypertension who fulfilled at least 3 of the metabolic syndrome criteria proposed by NCEP-ATP III were included in this prospective, randomized, controlled study. Patients were randomly assigned to receive daily treatment with carvedilol (n = 27, 12.5 mg/day orally for the first 2 days and 25 mg/day thereafter), atenolol (n = 26, 50 mg/day orally), or doxazosin (n = 24, 2 mg/day orally) for 90 days. Doses were doubled at the end of the 3rd week in patients whose blood pressure was inadequately controlled and amlodipine 10 mg was added to the treatment if the target blood pressure was still not reached at the end of week 6. The biochemical parameters and insulin sensitivity based on the HOMA-IR model were evaluated at baseline and at the end of treatment. Similar reductions in systolic and diastolic blood pressure were observed in all groups (P > 0.05). A significant decrease in HDL cholesterol levels occurred in the doxazosin and atenolol groups compared to the carvedilol group (percent change: -5.6 +/- 13.5 and -8 +/- 9.8 versus -0.1 +/- 12.2, respectively; P < 0.05) and a significant increase in apolipoprotein A1 level was observed in the carvedilol group compared to the doxazosin and atenolol groups (percent change: +4.3 +/- 9.6 versus -0.5 +/- 10.6 and -2.3 +/- 6.6, respectively; P < 0.05). There were no significant differences among the groups with respect to other parameters. It is concluded antihypertensive treatment with carvedilol in patients with metabolic syndrome effectively reduces blood pressure without adversely affecting metabolic parameters.
C1 Goztepe Training & Res Hosp, Dept Internal Med, TR-34843 Istanbul, Turkey.
C3 Istanbul Goztepe Training & Research Hospital
RP Uzunlulu, M (corresponding author), Goztepe Training & Res Hosp, Dept Internal Med, Altaycesme Mahallesi,Sarigul Sokak,Kuralkan Sites, TR-34843 Istanbul, Turkey.
RI Oguz, Aytekin/AAJ-2732-2021
CR Bakris GL, 2004, JAMA-J AM MED ASSOC, V292, P2227, DOI 10.1001/jama.292.18.2227
   Bell DSH, 2004, AM J CARDIOL, V93, p49B, DOI 10.1016/j.amjcard.2004.01.026
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Dahlöf B, 2002, LANCET, V359, P995, DOI 10.1016/S0140-6736(02)08089-3
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   GANG A, 1994, JAMA-J AM MED ASSOC, V271, P1421
   GIORDANO M, 1995, DIABETES, V44, P665, DOI 10.2337/diabetes.44.6.665
   Giugliano D, 1997, ANN INTERN MED, V126, P955, DOI 10.7326/0003-4819-126-12-199706150-00004
   GOTO Y, 1991, J CARDIOVASC PHARM, V18, pS45
   Haffner SM, 1996, DIABETES CARE, V19, P1138, DOI 10.2337/diacare.19.10.1138
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   HAUFZACHARIOU U, 1993, EUR J CLIN PHARMACOL, V45, P95, DOI 10.1007/BF00315487
   Ho WJ, 2004, JPN HEART J, V45, P823, DOI 10.1536/jhj.45.823
   Jacob S, 1998, AM J HYPERTENS, V11, P1258, DOI 10.1016/S0895-7061(98)00141-1
   Kontush A, 2005, ATHEROSCLEROSIS, V182, P277, DOI 10.1016/j.atherosclerosis.2005.03.001
   LITHELL HOL, 1991, DIABETES CARE, V14, P203, DOI 10.2337/diacare.14.3.203
   Maggio CA, 1997, DIABETES CARE, V20, P1744, DOI 10.2337/diacare.20.11.1744
   MAQUEDA IG, 1994, CORONARY ARTERY DIS, V5, P909
   Messerli FH, 2004, AM J CARDIOL, V93, p7B, DOI 10.1016/j.amjcard.2004.01.020
   Oda E, 2005, INT HEART J, V46, P975, DOI 10.1536/ihj.46.975
   POLLARE T, 1988, DIABETOLOGIA, V31, P415, DOI 10.1007/BF00271585
   POOLEWILSON PA, 2004, AM J CARDIOL S, V93
   Rader DJ, 2003, JAMA-J AM MED ASSOC, V290, P2322, DOI 10.1001/jama.290.17.2322
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   ROSSNER S, 1990, BMJ-BRIT MED J, V300, P902, DOI 10.1136/bmj.300.6729.902
   SEGUCHI H, 1990, EUR J CLIN PHARMACOL, V38, pS139, DOI 10.1007/BF01409484
   Yasunari K, 2004, AM J MED, V116, P460, DOI 10.1016/j.amjmed.2003.10.029
NR 27
TC 16
Z9 16
U1 0
U2 7
PU INT HEART JOURNAL ASSOC
PI TOKYO
PA UNIV TOKYO, GRADUATE SCHOOL MEDICINE, DEPT CARDIOVASCULAR MEDICINE,
   HONGO 7-3-1, BUNKYO-KU, TOKYO, 113-8655, JAPAN
SN 1349-2365
EI 1349-3299
J9 INT HEART J
JI Int. Heart J.
PD MAY
PY 2006
VL 47
IS 3
BP 421
EP 430
DI 10.1536/ihj.47.421
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 070XH
UT WOS:000239559300011
PM 16823248
OA Bronze
DA 2025-06-11
ER

PT J
AU Giangregorio, F
   Mosconi, E
   Debellis, MG
   Provini, S
   Esposito, C
   Garolfi, M
   Oraka, S
   Kaloudi, O
   Mustafazade, G
   Marín-Baselga, R
   Tung-Chen, Y
AF Giangregorio, Francesco
   Mosconi, Emilio
   Debellis, Maria Grazia
   Provini, Stella
   Esposito, Ciro
   Garolfi, Matteo
   Oraka, Simona
   Kaloudi, Olga
   Mustafazade, Gunel
   Marin-Baselga, Raquel
   Tung-Chen, Yale
TI A Systematic Review of Metabolic Syndrome: Key Correlated Pathologies
   and Non-Invasive Diagnostic Approaches
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE metabolic syndrome; non-invasive assessment; liver fibrosis;
   cardiovascular disease; hepatic steatosis
ID NONALCOHOLIC FATTY LIVER; CHRONIC HEART-FAILURE; PLATELET RATIO INDEX;
   MAGNETIC-RESONANCE ELASTOGRAPHY; CARDIOVASCULAR RISK-FACTORS; ALL-CAUSE
   MORTALITY; INSULIN-RESISTANCE; ASPARTATE-AMINOTRANSFERASE; HEPATIC
   STEATOSIS; FIBROSIS-4 INDEX
AB Background and Objectives: Metabolic syndrome (MetS) is a condition marked by a complex array of physiological, biochemical, and metabolic abnormalities, including central obesity, insulin resistance, high blood pressure, and dyslipidemia (characterized by elevated triglycerides and reduced levels of high-density lipoproteins). The pathogenesis develops from the accumulation of lipid droplets in the hepatocyte (steatosis). This accumulation, in genetically predisposed subjects and with other external stimuli (intestinal dysbiosis, high caloric diet, physical inactivity, stress), activates the production of pro-inflammatory molecules, alter autophagy, and turn on the activity of hepatic stellate cells (HSCs), provoking the low grade chronic inflammation and the fibrosis. This syndrome is associated with a significantly increased risk of developing type 2 diabetes mellitus (T2D), cardiovascular diseases (CVD), vascular, renal, pneumologic, rheumatological, sexual, cutaneous syndromes and overall mortality, with the risk rising five- to seven-fold for T2DM, three-fold for CVD, and one and a half-fold for all-cause mortality. The purpose of this narrative review is to examine metabolic syndrome as a "systemic disease" and its interaction with major internal medicine conditions such as CVD, diabetes, renal failure, and respiratory failure. It is essential for internal medicine practitioners to approach this widespread condition in a "holistic" rather than a fragmented manner, particularly in Western countries. Additionally, it is important to be aware of the non-invasive tools available for assessing this condition. Materials and Methods: We conducted an exhaustive search on PubMed up to July 2024, focusing on terms related to metabolic syndrome and other pathologies (heart, Lung (COPD, asthma, pulmonary hypertension, OSAS) and kidney failure, vascular, rheumatological (osteoarthritis, rheumatoid arthritis), endocrinological, sexual pathologies and neoplastic risks. The review was managed in accordance with the PRISMA statement. Finally, we selected 300 studies (233 papers for the first search strategy and 67 for the second one). Our review included studies that provided insights into metabolic syndrome and non-invasive techniques for evaluating liver fibrosis and steatosis. Studies that were not conducted on humans, were published in languages other than English, or did not assess changes related to heart failure were excluded. Results: The findings revealed a clear correlation between metabolic syndrome and all the pathologies above described, indicating that non-invasive assessments of hepatic fibrosis and steatosis could potentially serve as markers for the severity and progression of the diseases. Conclusions: Metabolic syndrome is a multisystem disorder that impacts organs beyond the liver and disrupts the functioning of various organs. Notably, it is linked to a higher incidence of cardiovascular diseases, independent of traditional cardiovascular risk factors. Non-invasive assessments of hepatic fibrosis and fibrosis allow clinicians to evaluate cardiovascular risk. Additionally, the ability to assess liver steatosis may open new diagnostic, therapeutic, and prognostic avenues for managing metabolic syndrome and its complications, particularly cardiovascular disease, which is the leading cause of death in these patients.
C1 [Giangregorio, Francesco; Mosconi, Emilio; Debellis, Maria Grazia; Provini, Stella; Esposito, Ciro; Garolfi, Matteo; Oraka, Simona; Kaloudi, Olga; Mustafazade, Gunel] Codogno Hosp, Dept Internal Med, Via Marconi 1, I-26900 Codogno, Italy.
   [Marin-Baselga, Raquel; Tung-Chen, Yale] Hosp Univ La Paz, Dept Internal Med, Paseo Castellana 241, Madrid 28046, Spain.
C3 Hospital Universitario La Paz
RP Tung-Chen, Y (corresponding author), Hosp Univ La Paz, Dept Internal Med, Paseo Castellana 241, Madrid 28046, Spain.
EM francesco.giangregorio@asst-lodi.it; emilio.mosconi@asst-lodi.it;
   mariagrazia.debellis@asst-lodi.it; stella.provini@ast-lodi.it;
   ciro.esposito@asst-lodi.it; matteo.garolfi@asst-lodi.it;
   simona.oraka@gmail.com; gunelmustafazade01@gmail.com;
   raquelzgz14@gmail.com; yale.tung@salud.madrid.org
RI tung chen, yale/AFS-6904-2022; Giangregorio, Francesco/K-6082-2013
OI Giangregorio, Francesco/0000-0002-5347-0183
CR Abella V, 2014, J IMMUNOL RES, V2014, DOI 10.1155/2014/343746
   Adiels M, 2008, ARTERIOSCL THROM VAS, V28, P1225, DOI 10.1161/ATVBAHA.107.160192
   Aguilar D, 2009, J AM COLL CARDIOL, V54, P422, DOI 10.1016/j.jacc.2009.04.049
   Ahn HJ, 2021, CARDIOVASC DIABETOL, V20, DOI 10.1186/s12933-021-01215-8
   Aizawa Y, 2006, INT J CARDIOL, V109, P213, DOI 10.1016/j.ijcard.2005.06.007
   Akkiz H, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25147873
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alemany M, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25042251
   Alemany M, 2021, WORLD J DIABETES, V12, P1622, DOI 10.4239/wjd.v12.i10.1622
   Alemany M, 2012, J ENDOCRINOL METAB, V2, P155, DOI 10.4021/jem116w
   Alemany M, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-74
   Alexander KS, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194153
   Ali AH, 2022, J CLIN MED, V11, DOI 10.3390/jcm11051201
   Almhmoud H, 2024, MEDICINE, V103, DOI 10.1097/MD.0000000000038647
   Alvarez-Troncoso J, 2022, J ULTRAS MED, V41, P1689, DOI 10.1002/jum.15850
   ANDERSON EA, 1991, J CLIN INVEST, V87, P2246, DOI 10.1172/JCI115260
   Anderson PJ, 2001, INT J OBESITY, V25, P1782, DOI 10.1038/sj.ijo.0801837
   Angelico F, 2005, J CLIN ENDOCR METAB, V90, P1578, DOI 10.1210/jc.2004-1024
   Angulo P, 2007, HEPATOLOGY, V45, P846, DOI 10.1002/hep.21496
   Angulo P, 2013, GASTROENTEROLOGY, V145, P782, DOI 10.1053/j.gastro.2013.06.057
   Anthony K, 2006, DIABETES, V55, P2986, DOI 10.2337/db06-0376
   Arai T, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-95581-8
   Arai T, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0224184
   Arcopinto M, 2019, HEART FAIL CLIN, V15, P349, DOI 10.1016/j.hfc.2019.02.004
   Arsenault BJ, 2010, EUR J CLIN INVEST, V40, P1081, DOI 10.1111/j.1365-2362.2010.02357.x
   Aziz R, 2023, OBESITIES-BASEL, V3, P46, DOI 10.3390/obesities3010005
   Baffi CW, 2016, CHEST, V149, P1525, DOI 10.1016/j.chest.2015.12.034
   Baratta F, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061732
   Baratta F, 2020, CLIN GASTROENTEROL H, V18, P2324, DOI 10.1016/j.cgh.2019.12.026
   Bedogni G, 2006, BMC GASTROENTEROL, V6, DOI 10.1186/1471-230X-6-33
   Bertot LC, 2018, LIVER INT, V38, P1793, DOI 10.1111/liv.13739
   Bjork S, 2024, SLEEP MED CLIN, V19, P307, DOI 10.1016/j.jsmc.2024.02.009
   Bloomgarden ZT, 2004, DIABETES CARE, V27, P3009, DOI 10.2337/diacare.27.12.3009
   Borst O, 2015, ARTERIOSCL THROM VAS, V35, P547, DOI 10.1161/ATVBAHA.114.304454
   Bradbury MW, 2006, AM J PHYSIOL-GASTR L, V290, pG194, DOI 10.1152/ajpgi.00413.2005
   Braunwald E, 2013, JACC-HEART FAIL, V1, P1, DOI 10.1016/j.jchf.2012.10.002
   Bremer AA, 2013, J OBES, V2013, DOI 10.1155/2013/393192
   Butler J, 2005, J AM COLL CARDIOL, V46, P1027, DOI 10.1016/j.jacc.2005.06.015
   Camastra S, 2022, REV ENDOCR METAB DIS, V23, P43, DOI 10.1007/s11154-021-09708-3
   Carli F, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms241914651
   Carli MALD, 2020, EUR J GASTROEN HEPAT, V32, P420, DOI 10.1097/MEG.0000000000001519
   Carlsson B, 2020, ALIMENT PHARM THER, V51, P1305, DOI 10.1111/apt.15738
   Zaha DC, 2020, EXP THER MED, V20, P121, DOI 10.3892/etm.2020.8663
   Carpino G, 2020, HEPATOLOGY, V72, P470, DOI 10.1002/hep.31056
   Carpino G, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-15943-z
   Caturano A, 2021, PROCESSES, V9, DOI 10.3390/pr9010135
   CELLE G, 1988, DIGEST DIS SCI, V33, P467, DOI 10.1007/BF01536033
   Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI 10.1002/hep.29367
   Chalasani N, 2012, HEPATOLOGY, V55, P2005, DOI 10.1002/hep.25762
   Chan SMH, 2019, PHARMACOL THERAPEUT, V198, P160, DOI 10.1016/j.pharmthera.2019.02.013
   Cheong KC, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2020-047849
   Chen WL, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0108989
   Chen YC, 2013, OBES REV, V14, P222, DOI 10.1111/j.1467-789X.2012.01055.x
   Chen YJ, 2008, ARCH DERMATOL, V144, P1571, DOI 10.1001/archderm.144.12.1571
   Choi HS, 2019, INT J CHRONIC OBSTR, V14, P2873, DOI 10.2147/COPD.S228497
   Chung GE, 2018, ATHEROSCLEROSIS, V272, P137, DOI 10.1016/j.atherosclerosis.2018.03.027
   Cortez-Pinto H, 1999, CLIN NUTR, V18, P353, DOI 10.1016/S0261-5614(99)80015-6
   Coutinho AE, 2011, MOL CELL ENDOCRINOL, V335, P2, DOI 10.1016/j.mce.2010.04.005
   Dasarathy S, 2014, HEPATOLOGY, V60, P22, DOI 10.1002/hep.27134
   Dasarathy S, 2009, J HEPATOL, V51, P1061, DOI 10.1016/j.jhep.2009.09.001
   Davos CH, 2003, J CARD FAIL, V9, P29, DOI 10.1054/jcaf.2003.4
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   de Mattos AZ, 2017, ANN HEPATOL, V16, P349, DOI 10.5604/16652681.1235477
   De Robertis R, 2023, RADIOL MED, V128, P1174, DOI 10.1007/s11547-023-01693-8
   de Souza JA, 2008, ATHEROSCLEROSIS, V197, P84, DOI 10.1016/j.atherosclerosis.2007.08.009
   DEFRONZO RA, 1975, J CLIN INVEST, V55, P845, DOI 10.1172/JCI107996
   Del Ben M, 2014, EUR J INTERN MED, V25, P566, DOI 10.1016/j.ejim.2014.05.012
   Denson JL, 2021, JAMA NETW OPEN, V4, DOI 10.1001/jamanetworkopen.2021.40568
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Di Costanzo A, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-21939-0
   Di Costanzo A, 2017, ATHEROSCLEROSIS, V257, P232, DOI 10.1016/j.atherosclerosis.2016.12.018
   Dietrich P, 2014, BEST PRACT RES CL GA, V28, P637, DOI 10.1016/j.bpg.2014.07.008
   Dillman JR, 2022, AM J ROENTGENOL, V219, P784, DOI 10.2214/AJR.22.27878
   Doehner W, 2005, J AM COLL CARDIOL, V46, P1019, DOI 10.1016/j.jacc.2005.02.093
   Doehner W, 2014, J AM COLL CARDIOL, V64, P1388, DOI 10.1016/j.jacc.2014.04.083
   Dunlay SM, 2011, CIRC-CARDIOVASC QUAL, V4, P68, DOI 10.1161/CIRCOUTCOMES.110.957225
   Dutka DP, 2006, J AM COLL CARDIOL, V48, P2225, DOI 10.1016/j.jacc.2006.06.078
   EASL, 2016, OBESITY FACTS, V9, P65, DOI [10.1159/000443344, 10.1007/s00125-016-3902-y, 10.1016/j.jhep.2015.11.004]
   Eslam M, 2020, J HEPATOL, V73, P202, DOI 10.1016/j.jhep.2020.03.039
   Eslam M, 2020, GASTROENTEROLOGY, V158, P1999, DOI 10.1053/j.gastro.2019.11.312
   Fang NN, 2022, METAB SYNDR RELAT D, V20, P606, DOI 10.1089/met.2022.0045
   Fede C, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms231911061
   Ferraioli G, 2024, ABDOM RADIOL, V49, P2622, DOI 10.1007/s00261-024-04413-6
   Ferraioli G, 2024, ULTRASOUND MED BIOL, V50, P1071, DOI 10.1016/j.ultrasmedbio.2024.03.013
   Ferraioli G, 2024, ULTRASOUND MED BIOL, V50, P1088, DOI 10.1016/j.ultrasmedbio.2024.03.014
   Ferraioli G, 2023, ULTRASONOGRAPHY, V42, P446, DOI 10.14366/usg.23014
   Ferro D, 2020, NUTRIENTS, V12, DOI 10.3390/nu12092762
   Francisco V, 2019, BIOCHEM PHARMACOL, V165, P196, DOI 10.1016/j.bcp.2019.03.030
   GABOURY CL, 1994, J CLIN INVEST, V94, P2295, DOI 10.1172/JCI117593
   Gallagher EJ, 2010, MT SINAI J MED, V77, P511, DOI 10.1002/msj.20212
   Gao Y, 2020, CARDIOVASC DIABETOL, V19, DOI 10.1186/s12933-020-01044-1
   Garbarino S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0097188
   Garmendia JV, 2014, RECENT PATENTS ENDOC, V8, P60, DOI 10.2174/1872214807666140107151023
   Garofolo M, 2024, CARDIOVASC DIABETOL, V23, DOI 10.1186/s12933-024-02171-9
   GARRA BS, 1987, RADIOLOGY, V162, P61, DOI 10.1148/radiology.162.1.3538154
   Geerling E, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.1015563
   Ghatas T., 2017, Egypt. J. Bronchol, V11, P11, DOI [10.4103/1687-8426.198983, DOI 10.4103/1687-8426.198983]
   Ghorbanian B, 2023, BRIT J NUTR, V130, P553, DOI 10.1017/S0007114522003580
   Giangregorio F., 2024, J. Clin. Med
   Gidener T, 2021, CLIN GASTROENTEROL H, V19, P1915, DOI 10.1016/j.cgh.2020.09.044
   Godoy-Matos AF, 2020, DIABETOL METAB SYNDR, V12, DOI 10.1186/s13098-020-00570-y
   Grossmann M, 2015, CLIN ENDOCRINOL, V83, P344, DOI 10.1111/cen.12664
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Gu JK, 2022, J OCCUP ENVIRON MED, V64, P748, DOI 10.1097/JOM.0000000000002569
   Gu JL, 2019, EUR RADIOL, V29, P3564, DOI 10.1007/s00330-019-06072-4
   Guarner V, 2015, INTERD T GERONT GERI, V40, P99, DOI 10.1159/000364934
   Hagström H, 2019, CLIN GASTROENTEROL H, V17, P1148, DOI 10.1016/j.cgh.2018.11.030
   Harrison SA, 2008, GUT, V57, P1441, DOI 10.1136/gut.2007.146019
   HAUNER H, 1989, J CLIN INVEST, V84, P1663, DOI 10.1172/JCI114345
   Heerkens L, 2023, PLOS ONE, V18, DOI 10.1371/journal.pone.0287467
   Holmang A, 1996, EUR J CLIN INVEST, V26, P973, DOI 10.1046/j.1365-2362.1996.2880577.x
   Horwich TB, 2010, J AM COLL CARDIOL, V55, P283, DOI 10.1016/j.jacc.2009.07.029
   Hu JP, 2018, ONCOTARGET, V9, P2752, DOI 10.18632/oncotarget.22755
   Ingawale DK, 2020, IMMUNOPHARM IMMUNOT, V42, P59, DOI 10.1080/08923973.2020.1728765
   Ingelsson E, 2006, HEART, V92, P1409, DOI 10.1136/hrt.2006.089011
   Ingelsson E, 2005, JAMA-J AM MED ASSOC, V294, P334, DOI 10.1001/jama.294.3.334
   Ioannou GN, 2019, GASTROENTEROLOGY, V157, P1264, DOI 10.1053/j.gastro.2019.07.033
   Ion RM, 2023, J CLIN MED, V12, DOI 10.3390/jcm12113818
   Jaeger M, 2015, PHYS MED BIOL, V60, P4497, DOI 10.1088/0031-9155/60/11/4497
   Jakubek P, 2024, INTERN EMERG MED, V19, P1473, DOI 10.1007/s11739-024-03700-w
   Jang JK, 2022, ULTRASONOGRAPHY, V41, P83, DOI 10.14366/usg.21076
   Jensen ME, 2013, EUR RESPIR J, V42, P1012, DOI 10.1183/09031936.00124912
   Johnson RJ, 2011, SEMIN NEPHROL, V31, P394, DOI 10.1016/j.semnephrol.2011.08.002
   Kalantar-Zadeh K, 2004, J AM COLL CARDIOL, V43, P1439, DOI 10.1016/j.jacc.2003.11.039
   KALIMI M, 1994, MOL CELL BIOCHEM, V131, P99, DOI 10.1007/BF00925945
   Kaneva AM, 2024, J PHYSIOL BIOCHEM, V80, P11, DOI 10.1007/s13105-023-00991-z
   Karadag AS, 2018, CLIN DERMATOL, V36, P48, DOI [10.1016/j.clindermatol.2017.09.008, 10.1016/j.clindermato1.2017.09.008]
   Käräjämäki AJ, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0142937
   Karamzad N, 2020, J CARDIOVASC THORAC, V12, P120, DOI 10.34172/jcvtr.2020.20
   Karra P, 2022, OBESITY, V30, P1323, DOI 10.1002/oby.23444
   Khadra D, 2020, CURR CARDIOL REV, V16, P153, DOI 10.2174/1573403X16666200214104122
   Khan SU, 2023, CLIN MED INSIGHTS-EN, V16, DOI 10.1177/11795514221145841
   Kicinska AM, 2023, BIOMEDICINES, V11, DOI 10.3390/biomedicines11061567
   Kim C, 2014, CURR CARDIOL REP, V16, DOI 10.1007/s11886-014-0467-6
   Kim JE, 2022, MOLECULES, V27, DOI 10.3390/molecules27020334
   Kim SU, 2020, MOD RHEUMATOL, V30, P70, DOI 10.1080/14397595.2018.1558760
   Kim SP, 2003, DIABETES, V52, P2453, DOI 10.2337/diabetes.52.10.2453
   Kitada M, 2021, NAT REV ENDOCRINOL, V17, P647, DOI 10.1038/s41574-021-00551-9
   Kobayashi N, 2017, DIGEST DIS, V35, P521, DOI 10.1159/000480142
   Korolczuk A, 2017, CURR PHARM DESIGN, V23, P1533, DOI 10.2174/1381612823666170124114524
   Kraja AT, 2007, NUTR METAB, V4, DOI 10.1186/1743-7075-4-28
   Kraus VB, 2015, OSTEOARTHR CARTILAGE, V23, P1233, DOI 10.1016/j.joca.2015.03.036
   Krentz AJ, 2009, J VASC RES, V46, P515, DOI 10.1159/000226220
   Kubale R, 2024, AM J ROENTGENOL, V222, DOI 10.2214/AJR.23.30775
   Kumar S, 2018, METAB SYNDR RELAT D, V16, P73, DOI 10.1089/met.2018.0012
   Kumari R, 2019, DIABETES METAB SYND, V13, P2409, DOI 10.1016/j.dsx.2019.06.005
   Kumor Marta, 2013, Pneumonol Alergol Pol, V81, P417
   Labenz C, 2020, DIGEST DIS SCI, V65, P2112, DOI 10.1007/s10620-019-05986-9
   Labyed Y, 2020, J ULTRAS MED, V39, P2427, DOI 10.1002/jum.15364
   Lee HH, 2020, CARDIOVASC DIABETOL, V19, DOI 10.1186/s12933-020-01064-x
   Lee TT, 2006, AM HEART J, V151, P76, DOI 10.1016/j.ahj.2005.03.009
   LEVINE TB, 1982, AM J CARDIOL, V49, P1659, DOI 10.1016/0002-9149(82)90243-0
   Li CY, 2007, J EPIDEMIOL COMMUN H, V61, P67, DOI 10.1136/jech.2006.048173
   Lin LR, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.904001
   Liu SS, 2024, BMC PUBLIC HEALTH, V24, DOI 10.1186/s12889-024-18782-6
   London A, 2021, J CLIN MED, V10, DOI 10.3390/jcm10030390
   LUDWIG J, 1980, MAYO CLIN PROC, V55, P434
   Luna-Luna M, 2015, ARCH MED RES, V46, P392, DOI 10.1016/j.arcmed.2015.05.007
   Lundsgaard AM, 2017, DIABETES, V66, P2583, DOI 10.2337/db17-0046
   Maeda K, 2019, ALLERGY, V74, P1660, DOI 10.1111/all.13788
   Mahamid M, 2019, DIABETES METAB SYNDR, V12, P1743, DOI 10.2147/DMSO.S205568
   Maher AC, 2010, PHYSIOL GENOMICS, V42, P342, DOI 10.1152/physiolgenomics.00016.2010
   Mancia G, 2010, J HYPERTENS, V28, P999, DOI 10.1097/HJH.0b013e328337a9e3
   Mancuso P, 2010, J APPL PHYSIOL, V108, P722, DOI 10.1152/japplphysiol.00781.2009
   Mantovani A, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0135329
   Maron BA, 2020, BRIT J PHARMACOL, V177, P1457, DOI 10.1111/bph.14968
   Masenga SK, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24097898
   Mathew R, 2014, WORLD J CARDIOL, V6, P692, DOI 10.4330/wjc.v6.i8.692
   Matteoni CA, 1999, GASTROENTEROLOGY, V116, P1413, DOI 10.1016/S0016-5085(99)70506-8
   Matwiejuk M, 2024, J CLIN MED, V13, DOI 10.3390/jcm13010109
   Mbata O, 2017, WORLD J DIABETES, V8, P317, DOI 10.4239/wjd.v8.i7.317
   McPherson S, 2010, GUT, V59, P1265, DOI 10.1136/gut.2010.216077
   Middleton MS, 2017, GASTROENTEROLOGY, V153, P753, DOI 10.1053/j.gastro.2017.06.005
   Migrenne S, 2011, DIABETES METAB, V37, P83, DOI 10.1016/j.diabet.2010.11.001
   Misan IA, 2023, KARDIOLOGIYA, V63, P72, DOI 10.18087/cardio.2023.12.n2360
   Miura Y, 2010, CIRC J, V74, P2612, DOI 10.1253/circj.CJ-10-0677
   Moghadam-Ahmadi A, 2023, BMC ENDOCR DISORD, V23, DOI 10.1186/s12902-023-01383-6
   Montecucco F, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/135984
   Mottin CC, 2004, OBES SURG, V14, P635, DOI 10.1381/096089204323093408
   Nalbantoglu I, 2014, WORLD J GASTROENTERO, V20, P9026, DOI 10.3748/wjg.v20.i27.9026
   Nichols GA, 2023, METAB SYNDR RELAT D, V21, P261, DOI 10.1089/met.2023.0006
   Nikolaidis LA, 2004, CARDIOVASC RES, V61, P297, DOI 10.1016/j.cardiores.2003.11.027
   Nishikawa H, 2017, J CANCER, V8, P152, DOI 10.7150/jca.16523
   Niu YY, 2023, FRONT CARDIOVASC MED, V10, DOI 10.3389/fcvm.2023.1171754
   Nolan CJ, 2019, DIABETES VASC DIS RE, V16, P118, DOI 10.1177/1479164119827611
   Nunes DC, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24031960
   Obi EN, 2016, J MANAG CARE SPEC PH, V22, P1446, DOI 10.18553/jmcp.2016.22.12.1446
   Obunai K, 2007, MED CLIN N AM, V91, P1169, DOI 10.1016/j.mcna.2007.06.003
   Ormachea J, 2022, ULTRASOUND MED BIOL, V48, P675, DOI 10.1016/j.ultrasmedbio.2021.12.009
   Page MJ, 2021, BMJ-BRIT MED J, V372, DOI [10.1136/bmj.n71, 10.1136/bmj.n160]
   Paige JS, 2017, AM J ROENTGENOL, V208, pW168, DOI 10.2214/AJR.16.16726
   Palmentieri B, 2006, DIGEST LIVER DIS, V38, P485, DOI 10.1016/j.dld.2006.03.021
   Pan XF, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0229776
   PAOLISSO G, 1991, METABOLISM, V40, P972, DOI 10.1016/0026-0495(91)90075-8
   Paradis V, 2008, DIABETES METAB, V34, P638, DOI 10.1016/S1262-3636(08)74598-1
   Park CC, 2017, GASTROENTEROLOGY, V152, P598, DOI 10.1053/j.gastro.2016.10.026
   Park HJ, 2019, BMC GASTROENTEROL, V19, DOI 10.1186/s12876-019-1007-z
   Park J, 2022, CARDIOVASC DIABETOL, V21, DOI 10.1186/s12933-022-01725-z
   Park J, 2021, CARDIOVASC DIABETOL, V20, DOI 10.1186/s12933-021-01374-8
   Patel YA, 2018, DIGEST DIS SCI, V63, P2259, DOI 10.1007/s10620-018-5123-3
   PEKKANEN J, 1990, NEW ENGL J MED, V322, P1700, DOI 10.1056/NEJM199006143222403
   Perrone-Filardi P, 2015, INT J CARDIOL, V178, P85, DOI 10.1016/j.ijcard.2014.10.094
   Piazzolla G, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0186708
   Pocock SJ, 2006, EUR HEART J, V27, P65, DOI 10.1093/eurheartj/ehi555
   Polimeni L, 2015, WORLD J HEPATOL, V7, P1325, DOI 10.4254/wjh.v7.i10.1325
   Prasad G V Ramesh, 2014, World J Nephrol, V3, P210, DOI 10.5527/wjn.v3.i4.210
   Prasun P, 2020, BBA-MOL BASIS DIS, V1866, DOI 10.1016/j.bbadis.2020.165838
   Purslow PP, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.00495
   Rana JS, 2007, DIABETES OBES METAB, V9, P218, DOI 10.1111/j.1463-1326.2006.00594.x
   Raphael CE, 2009, HEART, V95, P56, DOI 10.1136/hrt.2007.134973
   Rasouli N, 2007, DIABETES OBES METAB, V9, P1, DOI 10.1111/j.1463-1326.2006.00590.x
   Raya-Cano E, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-22025-2
   Reddy JK, 2006, AM J PHYSIOL-GASTR L, V290, pG852, DOI 10.1152/ajpgi.00521.2005
   Remesar X, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21207729
   Rinella ME, 2023, HEPATOLOGY, V77, P1797, DOI 10.1097/HEP.0000000000000323
   Rinella ME, 2023, J HEPATOL, V79, P1542, DOI 10.1016/j.jhep.2023.06.003
   Rivera-Esteban J, 2023, GASTROENT HEPAT-BARC, V46, P682, DOI 10.1016/j.gastrohep.2022.11.001
   Rodrigues TC, 2011, J ENDOCRINOL INVEST, V34, pE58, DOI [10.1007/BF03347077, 10.3275/7264]
   Romeo GR, 2012, ARTERIOSCL THROM VAS, V32, P1771, DOI 10.1161/ATVBAHA.111.241869
   Ruhl CE, 2015, ALIMENT PHARM THER, V41, P65, DOI 10.1111/apt.13012
   Saadeh S, 2002, GASTROENTEROLOGY, V123, P745, DOI 10.1053/gast.2002.35354
   Saccà L, 2009, CIRC-HEART FAIL, V2, P151, DOI 10.1161/CIRCHEARTFAILURE.108.821892
   Saito Y, 2020, J CLIN MED, V9, DOI 10.3390/jcm9020584
   Samsamshariat S, 2019, ADV BIOMED RES-INDIA, V8, DOI 10.4103/abr.abr_126_18
   SANDFORD NL, 1985, GASTROENTEROLOGY, V89, P186, DOI 10.1016/0016-5085(85)90761-9
   SAVERYMUTTU SH, 1986, BMJ-BRIT MED J, V292, P13, DOI 10.1136/bmj.292.6512.13
   SCHAFFNER F, 1986, PROG LIVER DIS, V8, P283
   Schneeberger M, 2014, J ENDOCRINOL, V220, pT25, DOI 10.1530/JOE-13-0398
   Scurt FG, 2024, OBES REV, V25, DOI 10.1111/obr.13649
   Sebastiani G, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0128774
   Seeley RJ, 2005, OBES REV, V6, P259, DOI 10.1111/j.1467-789X.2005.00193.x
   Serfaty L, 2008, DIABETES METAB, V34, P634, DOI 10.1016/S1262-3636(08)74597-X
   Shah AG, 2009, CLIN GASTROENTEROL H, V7, P1104, DOI 10.1016/j.cgh.2009.05.033
   Shen QH, 2024, FRONT ENDOCRINOL, V15, DOI 10.3389/fendo.2024.1374644
   Shimba A, 2020, SEMIN IMMUNOPATHOL, V42, P669, DOI 10.1007/s00281-020-00827-8
   Shirai K, 2004, CURR MED RES OPIN, V20, P295, DOI 10.1185/030079903125003008
   Rossi JLS, 2022, DIABETES-METAB RES, V38, DOI 10.1002/dmrr.3502
   Sitar-Taut AV, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9111657
   Skórzewska A, 2021, POSTEP PSYCHIATR NEU, V30, P197, DOI 10.5114/ppn.2021.110791
   Smith U, 2015, J CLIN INVEST, V125, P1790, DOI 10.1172/JCI81507
   Smolen JS, 2016, LANCET, V388, P2023, DOI 10.1016/S0140-6736(16)30173-8
   Soleimani M, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24054294
   Sookoian S, 2008, J HEPATOL, V49, P600, DOI 10.1016/j.jhep.2008.06.012
   Stefanadi EC, 2018, DIABETOL METAB SYNDR, V10, DOI 10.1186/s13098-018-0311-z
   Stefater MA, 2010, ANNU REV NUTR, V30, P219, DOI 10.1146/annurev.nutr.012809.104723
   Sterling RK, 2006, HEPATOLOGY, V43, P1317, DOI 10.1002/hep.21178
   Stine JG, 2021, CLIN GASTROENTEROL H, V19, P2274, DOI 10.1016/j.cgh.2020.08.061
   Sumida Y, 2021, LIFE-BASEL, V11, DOI 10.3390/life11020143
   Sumida Y, 2012, BMC GASTROENTEROL, V12, DOI 10.1186/1471-230X-12-2
   Sun WJ, 2016, HEPATOL RES, V46, P862, DOI 10.1111/hepr.12647
   Suskin N., 2000, EUR HEART J EUR HEART J EUR HEART J EUR HEART J EUR HEART J EUR HEART J EUR HEART J EUR HEART J EUR HEART J EUR HEART J EUR HEART J EUR HEART J EUR HEART J EUR HEART J EUR HEART J EUR HEART J EUR HEART J, V21, P1368, DOI 10.1053/euhj.1999.2043
   Swan JW, 1997, J AM COLL CARDIOL, V30, P527, DOI 10.1016/S0735-1097(97)00185-X
   Tada T, 2017, HEPATOL COMMUN, V1, P899, DOI 10.1002/hep4.1105
   Tait AS, 2008, J LEUKOCYTE BIOL, V84, P924, DOI 10.1189/jlb.0208104
   Tamariz L, 2009, CLIN CARDIOL, V32, P327, DOI 10.1002/clc.20496
   Tan Q., 2021, Med. Novel Technol. Devices, V9, DOI [10.1016/j.medntd.2020.100052, DOI 10.1016/J.MEDNTD.2020.100052]
   Tarantino G, 2007, J GASTROEN HEPATOL, V22, P293, DOI 10.1111/j.1440-1746.2007.04824.x
   Targher G, 2005, ARTERIOSCL THROM VAS, V25, P2687, DOI 10.1161/01.ATV.0000189299.61568.79
   Targher G, 2017, EUR J HEART FAIL, V19, P54, DOI 10.1002/ejhf.679
   Taves MD, 2021, NAT REV IMMUNOL, V21, P233, DOI 10.1038/s41577-020-00464-0
   TAYLOR KJW, 1986, RADIOLOGY, V160, P65, DOI 10.1148/radiology.160.1.3520657
   Thomas GN, 2007, CLIN ENDOCRINOL, V66, P666, DOI 10.1111/j.1365-2265.2007.02798.x
   Tilg H, 2010, HEPATOLOGY, V52, P1836, DOI 10.1002/hep.24001
   Tseng TC, 2018, ALIMENT PHARM THER, V47, P1480, DOI 10.1111/apt.14619
   Tseng TC, 2017, AM J GASTROENTEROL, V112, P1564, DOI 10.1038/ajg.2017.254
   Tune JD, 2017, TRANSL RES, V183, P57, DOI 10.1016/j.trsl.2017.01.001
   Unalp-Arida A, 2017, HEPATOLOGY, V66, P84, DOI 10.1002/hep.29113
   Ussavarungsi K, 2017, CLIN RESPIR J, V11, P721, DOI 10.1111/crj.12406
   Uzunlulu M, 2016, ANN NUTR METAB, V68, P173, DOI 10.1159/000443743
   Vallet-Pichard A, 2007, HEPATOLOGY, V46, P32, DOI 10.1002/hep.21669
   Vergani L, 2019, CURR MED CHEM, V26, P3439, DOI 10.2174/0929867324666170518101334
   Wai CT, 2003, HEPATOLOGY, V38, P518, DOI 10.1053/jhep.2003.50346
   Wang S.C., 2017, Cardiovasc. Disord. Med, V3, P1, DOI [10.15761/CDM.1000158, DOI 10.15761/CDM.1000158, 10.15761/cdm.1000158]
   Wang XH, 2023, ULTRASOUND MED BIOL, V49, P2327, DOI 10.1016/j.ultrasmedbio.2023.06.021
   Weissmann G, 2006, BULL HOSP JT DIS, V64, P12
   Wesolek A, 2022, J PHYSIOL PHARMACOL, V73, DOI 10.26402/jpp.2022.1.13
   Whaley-Connell A, 2018, CARDIORENAL MED, V8, P41, DOI 10.1159/000479801
   Willson C, 2019, J PHYSIOL-LONDON, V597, P1121, DOI 10.1113/JP275856
   Wu J, 2012, OBES SURG, V22, P240, DOI 10.1007/s11695-011-0509-8
   Wu MZ, 2023, DIABETES OBES METAB, V25, P707, DOI 10.1111/dom.14916
   Xiao GQ, 2017, HEPATOLOGY, V66, P1486, DOI 10.1002/hep.29302
   Xiao GQ, 2015, HEPATOLOGY, V61, P292, DOI 10.1002/hep.27382
   Xun YH, 2014, CLIN EXP PHARMACOL P, V41, P643, DOI 10.1111/1440-1681.12260
   Yancy CW, 2016, CIRCULATION, V134, pE282, DOI 10.1161/CIR.0000000000000435
   Yeh F, 2011, DIABETES CARE, V34, P2306, DOI 10.2337/dc11-0682
   Yin CY, 2020, PEDIATR DIABETES, V21, P1132, DOI 10.1111/pedi.13101
   Yin M, 2024, AM J ROENTGENOL, V222, DOI 10.2214/AJR.23.29437
   Ying I, 2011, EPIDEMIOLOGY, V22, P129, DOI 10.1097/EDE.0b013e3181feb50a
   Yip TCF, 2023, MED CLIN N AM, V107, P449, DOI 10.1016/j.mcna.2022.12.003
   Yong SH, 2020, INT J CHRONIC OBSTR, V15, P831, DOI 10.2147/COPD.S242863
   Yoo JJ, 2022, J CLIN MED, V11, DOI 10.3390/jcm11040935
   Younossi ZM, 2024, CLIN GASTROENTEROL H, V22, P1999, DOI 10.1016/j.cgh.2024.03.006
   Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431
   Zalcman M, 2023, PEDIATR RADIOL, V53, P2466, DOI 10.1007/s00247-023-05752-0
   Zhang X, 2017, TRANSL RES, V183, P14, DOI 10.1016/j.trsl.2016.12.004
   Zhu L, 2020, J CLIN MED, V9, DOI 10.3390/jcm9123871
   Zhu YL, 2024, ABDOM RADIOL, V49, P81, DOI 10.1007/s00261-023-04078-7
   Zhuo Q, 2012, NAT REV RHEUMATOL, V8, P729, DOI 10.1038/nrrheum.2012.135
   Zimmet P, 1999, ANN NY ACAD SCI, V892, P25, DOI 10.1111/j.1749-6632.1999.tb07783.x
   Zou YW, 2017, INTERN MED J, V47, P1147, DOI 10.1111/imj.13549
NR 300
TC 4
Z9 4
U1 2
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD OCT
PY 2024
VL 13
IS 19
AR 5880
DI 10.3390/jcm13195880
PG 37
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA I7I5G
UT WOS:001331958900001
PM 39407941
OA gold
DA 2025-06-11
ER

PT J
AU Doghri, Y
   Chetaneau, F
   Rhimi, M
   Kriaa, A
   Lalanne, V
   Thorin, C
   Maguin, E
   Mallem, MY
   Desfontis, JC
AF Doghri, Yosra
   Chetaneau, Fabien
   Rhimi, Moez
   Kriaa, Aicha
   Lalanne, Valerie
   Thorin, Chantal
   Maguin, Emmanuelle
   Mallem, M. Yassine
   Desfontis, Jean-Claude
TI Sildenafil citrate long-term treatment effects on cardiovascular
   reactivity in a SHR experimental model of metabolic syndrome
SO PLOS ONE
LA English
DT Article
ID SPONTANEOUSLY HYPERTENSIVE-RATS; DIET-INDUCED OBESITY; GUT MICROBIOTA;
   HIGH-FAT; ENDOTHELIAL DYSFUNCTION; VASORELAXATION; RESISTANCE; AORTA
AB Much evidence indicates that metabolic syndrome is strongly correlated with a decrease in nitric oxide and an increase in oxidative stress leading to cardiovascular alterations. In recent years, gut microbiota has emerged as a new contributor to the metabolic syndrome establishment and associated cardiovascular diseases, but the underlying mechanisms remain unclear. We hypothesized that a positive modulation of cyclic guanosine monophosphate (cGMP) pathway, through phosphodiesterase type 5 (PDE5) inhibition could prevent cardiovascular alterations and gut dysbiosis that may be associated to metabolic syndrome. Spontaneously hypertensive rats (SHR) were randomly divided into 4 groups: control, cafeteria diet (CD) and sildenafil citrate treated groups (5mg/kg per os) were given either a CD or a standard chow diet for 10 weeks. Body weight, arterial blood pressure and glucose tolerance test were monitored. At the 10th week, cardiac inotropy and coronary perfusion pressure were evaluated on isolated heart according to Langendorff method. Cumulative concentration response curves to phenylephrine and acetylcholine were determined on thoracic aorta rings for vascular reactivity evaluation. Faecal samples were collected for the gut microbiota analysis. Compared to the control group, CD-fed rats showed a significant increase in body weight gain, arterial blood pressure and were glucose intolerant. This group showed also a decrease in beta-adrenoceptor-induced cardiac inotropy and coronary vasodilation. Gut microbiota analysis revealed a significant reduction in the abundance of Lactobocillus spp in cafeteria diet-fed rats when compared to the control ones. Sildenafil citrate long-term treatment decreased weight gain and arterial blood pressure, improved coronary vasodilation and reduced a 1-adrenoceptor-induced vasoconstriction in CD group. However, it did not reverse gut dysbiosis induced by chronic CD feeding. These results suggest that cGMP pathway targeting may be a potential therapeutic strategy for the management of the metabolic syndrome and associated cardiovascular disorders.
C1 [Doghri, Yosra; Chetaneau, Fabien; Lalanne, Valerie; Thorin, Chantal; Mallem, M. Yassine; Desfontis, Jean-Claude] Oniris, Coll Vet Med Food Sci & Engn, Atlanpole La Chantrerie, UPSP NP3 2017 B6146,Nutr Pathophysiol & Pharmacol, Route Gachet,5 BP, Nantes, France.
   [Rhimi, Moez; Kriaa, Aicha; Maguin, Emmanuelle] Univ Paris Saclay, UMR Micalis 1319, INRA, AgroParisTech,Microbiota Interact Human & Anim Te, Jouy En Josas, France.
C3 Ecole Nationale Veterinaire, Agroalimentaire et de l'Alimentation
   Nantes-Atlantique; AgroParisTech; INRAE; Universite Paris Saclay
RP Doghri, Y (corresponding author), Oniris, Coll Vet Med Food Sci & Engn, Atlanpole La Chantrerie, UPSP NP3 2017 B6146,Nutr Pathophysiol & Pharmacol, Route Gachet,5 BP, Nantes, France.
EM yosra.doghri@oniris-nantes.fr
RI Kriaa, Aisha/HLH-2445-2023; Desfontis, Jean-Claude/AAA-1623-2022;
   MALLEM, yassine/AHD-1776-2022
OI Maguin, Emmanuelle/0000-0001-5452-3382; MALLEM,
   yassine/0000-0001-5867-580X; Desfontis, Jean-Claude/0000-0002-1124-7979;
   RHIMI, Moez/0000-0001-8067-6526
CR Ahirwar AK, 2015, HORM MOL BIOL CLIN I, V24, P131, DOI 10.1515/hmbci-2015-0039
   Andric SA, 2010, AM J PHYSIOL-ENDOC M, V299, pE544, DOI 10.1152/ajpendo.00337.2010
   Arshad N, 2013, WIRES SYST BIOL MED, V5, P409, DOI 10.1002/wsbm.1223
   Ayala JE, 2007, DIABETES, V56, P1025, DOI 10.2337/db06-0883
   BENJAMINI Y, 1995, J R STAT SOC B, V57, P289, DOI 10.1111/j.2517-6161.1995.tb02031.x
   Berenyiova A, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/2502843
   Bleau C, 2015, DIABETES-METAB RES, V31, P545, DOI 10.1002/dmrr.2617
   Bortolin RC, 2018, INT J OBESITY, V42, P525, DOI 10.1038/ijo.2017.225
   Brandt N, 2010, AM J PHYSIOL-ENDOC M, V299, pE215, DOI 10.1152/ajpendo.00098.2010
   Buglioni A, 2016, ANNU REV MED, V67, P229, DOI 10.1146/annurev-med-052914-091923
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   del Bas JM, 2018, INT J OBESITY, V42, P746, DOI 10.1038/ijo.2017.284
   Everard A, 2013, BEST PRACT RES CL GA, V27, P73, DOI 10.1016/j.bpg.2013.03.007
   Festi D, 2014, WORLD J GASTROENTERO, V20, P16079, DOI 10.3748/wjg.v20.i43.16079
   Goldstein I, 2016, J SEX MED, V13, P852, DOI 10.1016/j.jsxm.2016.02.166
   Graham DA, 2004, J APPL PHYSIOL, V96, P2088, DOI 10.1152/japplphysiol.01252.2003
   He MQ, 2017, CELL BIOSCI, V7, DOI 10.1186/s13578-017-0183-1
   Ho JE, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.114.001001
   Jandhyala SM, 2015, WORLD J GASTROENTERO, V21, P8787, DOI 10.3748/wjg.v21.i29.8787
   Jiang C, 2015, CRIT CARE MED, V43, pE241, DOI 10.1097/CCM.0000000000000999
   Johann K, 2018, NUTR DIABETES, V8, DOI 10.1038/s41387-018-0026-0
   Kanso H, 2014, INT DAIRY J, V39, P113, DOI 10.1016/j.idairyj.2014.05.004
   Kim JA, 2015, AM J PHYSIOL-ENDOC M, V309, pE767, DOI 10.1152/ajpendo.00369.2015
   Lambert GW, 2010, PHARMACOL THERAPEUT, V126, P159, DOI 10.1016/j.pharmthera.2010.02.002
   Lecomte V, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0126931
   Lima-Leopoldo AP, 2011, ARQ BRAS CARDIOL, V97, P232, DOI 10.1590/S0066-782X2011005000061
   Lorkowska B, 2006, J PHARMACOL EXP THER, V317, P1019, DOI 10.1124/jpet.105.098798
   Lunardi CN, 2007, VASC PHARMACOL, V47, P139, DOI 10.1016/j.vph.2007.05.003
   Mergia E, 2016, CURR HYPERTENS REP, V18, DOI 10.1007/s11906-016-0646-5
   Miesel A, 2010, ANN NUTR METAB, V56, P127, DOI 10.1159/000278748
   Moreno-Fernández S, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101502
   MORENOINDIAS I, 2014, FRONT MICROBIOL, V5, DOI DOI 10.1016/J.351.325
   Nevelsteen I, 2013, BMC CARDIOVASC DISOR, V13, DOI 10.1186/1471-2261-13-51
   Okubo H, 2018, CURR MED CHEM, V25, P984, DOI 10.2174/0929867324666171009121702
   Rehakova R, 2016, PHYSIOL RES, V65, pS401, DOI 10.33549/physiolres.933440
   Rengo Giuseppe, 2014, Front Physiol, V5, P356, DOI 10.3389/fphys.2014.00356
   Rentoukas E, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035739
   Round J, 2018, STUD COMICS, V9, P3, DOI 10.1386/stic.9.1.3_2
   Ryu SY, 2018, WORLD J MENS HEALTH, V36, P41, DOI 10.5534/wjmh.17028
   Sauvaget F, 2010, EUR J PHARMACOL, V644, P169, DOI 10.1016/j.ejphar.2010.07.003
   SCHIRNER M, 1993, BRIT J PHARMACOL, V109, P900, DOI 10.1111/j.1476-5381.1993.tb13704.x
   Skrzypiec-Spring Monika, 2007, Journal of Pharmacological and Toxicological Methods, V55, P113, DOI 10.1016/j.vascn.2006.05.006
   Tanida M, 2008, OBES RES CLIN PRACT, V2, P159, DOI 10.1016/j.orcp.2008.04.003
   Teixeira-da-Silva JJ, 2019, LIFE SCI, V225, P29, DOI 10.1016/j.lfs.2019.03.074
   Thorin C, 2010, J PHARM PHARMACOL, V62, P339, DOI 10.1211/jpp.62.03.0008
   Velasquez MT, 2018, METAB SYNDR RELAT D, V16, P321, DOI 10.1089/met.2017.0163
   Weiss R, 2013, ANN NY ACAD SCI, V1281, P123, DOI 10.1111/nyas.12030
   Wong SK, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0123-9
   Yaguas K, 2010, AM J NEPHROL, V31, P283, DOI 10.1159/000279307
   Yang T, 2015, HYPERTENSION, V65, P1331, DOI 10.1161/HYPERTENSIONAHA.115.05315
   Yu J, 2016, PHYSIOL RES, V65, P209, DOI 10.33549/physiolres.933007
NR 51
TC 8
Z9 8
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 7
PY 2019
VL 14
IS 11
AR e0223914
DI 10.1371/journal.pone.0223914
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA LN1GV
UT WOS:000532694400015
PM 31697707
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Doghri, Y
   Dubreil, L
   Lalanne, V
   Hélissen, O
   Fleurisson, R
   Thorin, C
   Desfontis, JC
   Mallem, MY
AF Doghri, Yosra
   Dubreil, Laurence
   Lalanne, Valerie
   Helissen, Ophelie
   Fleurisson, Romain
   Thorin, Chantal
   Desfontis, Jean-Claude
   Mallem, M. Yassine
TI Soluble guanylate cyclase chronic stimulation effects on cardiovascular
   reactivity in cafeteria diet-induced rat model of metabolic syndrome
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Metabolic syndrome; sGC stimulation; SHR; Cafeteria diet; Cardiovascular
   reactivity
ID SPONTANEOUSLY HYPERTENSIVE-RATS; ENDOTHELIAL DYSFUNCTION; OXIDATIVE
   STRESS; BLOOD-PRESSURE; VASCULAR FUNCTION; THORACIC AORTA; INSULIN
   ACTION; BAY 41-2272; OBESE; RESISTANCE
AB Metabolic syndrome is linked to an increased risk of cardiovascular complications by a mechanism involving mainly decreased nitric oxide (NO) bioavailability and impaired NO-soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP) signalling (NO-sGC-cGMP). To further develop this scientific point, this study aimed to investigate the effects of long-term treatment with BAY 41-2272 (a sGC stimulator) on cardiovascular reactivity of spontaneously hypertensive rats (SHR) as a model of metabolic syndrome. SHR were randomly divided into 3 groups: control group, cafeteria diet (CD)-fed group and CD-fed group treated daily with BAY 41-2272 (5 mg/kg) by gastric gavage for 12 weeks. In vivo measurements of body weight, abdominal circumference, blood pressure and glucose tolerance test were performed. At the end of the feeding period, ex vivo cumulative concentration-response curves were performed on isolated perfused heart (isoproterenol (0.1 nM - 1 mu M)) and thoracic aorta (phenylephrine (1 nM-10 mu M), acetylcholine (1 nM-10 mu M), and sodium nitroprusside (SNP) (0.1 nM-0.1 mu M)). We showed that chronic CD feeding induced abdominal obesity, hypertriglyceridemia, glucose intolerance and exacerbated arterial hypertension in SHR. Compared to control group, CD-fed group showed a decrease in beta-adrenoceptor-induced cardiac inotropy, in coronary perfusion pressure and in aortic contraction to phenylephrine. While relaxing effects of acetylcholine and SNP were unchanged. BAY 41-2272 long-term treatment markedly prevented arterial hypertension development and glucose intolerance, enhanced the alpha(1)-adrenoceptor-induced vasoconstriction, and restored cardiac inotropy and coronary vasodilation. These findings suggest that BAY 41-2272 may be a potential novel drug for preventing metabolic and cardiovascular complications of metabolic syndrome.
C1 [Doghri, Yosra; Lalanne, Valerie; Helissen, Ophelie; Thorin, Chantal; Desfontis, Jean-Claude; Mallem, M. Yassine] Nantes Atlantic Coll Vet Med Food Sci & Engn, Oniris, UPSP NP3 2017 B146, Nutr Pathophysiol & Pharmacol, F-44307 Nantes 03, France.
   [Dubreil, Laurence; Fleurisson, Romain] Nantes Atlantic Coll Vet Med Food Sci & Engn, Oniris, UMR PAnTher 703 INRA Oniris Anim Pathophysiol & B, F-44307 Nantes 03, France.
C3 Ecole Nationale Veterinaire, Agroalimentaire et de l'Alimentation
   Nantes-Atlantique; Ecole Nationale Veterinaire, Agroalimentaire et de
   l'Alimentation Nantes-Atlantique; INRAE
RP Mallem, MY (corresponding author), Nantes Atlantic Coll Vet Med Food Sci & Engn, Oniris, UPSP NP3 2017 B146, Nutr Pathophysiol & Pharmacol, F-44307 Nantes 03, France.
EM yassine.mallem@oniris-nantes.fr
RI Desfontis, Jean-Claude/AAA-1623-2022; MALLEM, yassine/AHD-1776-2022
OI Desfontis, Jean-Claude/0000-0002-1124-7979; MALLEM,
   yassine/0000-0001-5867-580X
CR Abd El Aziz R, 2018, THER ADV ENDOCRINOL, V9, P43, DOI 10.1177/2042018817750823
   Anishchenko AM, 2015, B EXP BIOL MED+, V159, P591, DOI 10.1007/s10517-015-3020-8
   Araujo HN, 2018, CLIN EXP PHARMACOL P, V45, P293, DOI 10.1111/1440-1681.12882
   Aschner P, 2010, EXPERT REV CARDIOVAS, V8, P407, DOI 10.1586/ERC.10.13
   Ayala JE, 2007, DIABETES, V56, P1025, DOI 10.2337/db06-0883
   Battault S, 2018, AM J PHYSIOL-HEART C, V314, pH497, DOI 10.1152/ajpheart.00217.2017
   Berenyiova A, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/2502843
   Bhatta A, 2017, CARDIOVASC RES, V113, P1664, DOI 10.1093/cvr/cvx164
   Boerrigter G, 2007, CARDIOVASC DRUG REV, V25, P30, DOI 10.1111/j.1527-3466.2007.00003.x
   Breitenstein S, 2017, HANDB EXP PHARMACOL, V243, P225, DOI 10.1007/164_2016_100
   Cebova M, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/5413423
   Chamorro V, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0191239
   Doghri Y, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0223914
   El-Bassossy HM, 2014, TOXICOL MECH METHOD, V24, P536, DOI 10.3109/15376516.2014.945109
   Fernandes T, 2017, ADV EXP MED BIOL, V1000, P211, DOI 10.1007/978-981-10-4304-8_13
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Geschka S, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0021853
   Haas B, 2009, SCI SIGNAL, V2, DOI 10.1126/scisignal.2000511
   Hoffmann LS, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8235
   Ilkun O, 2013, CURR PHARM DESIGN, V19, P4806, DOI 10.2174/1381612811319270003
   Jiang C, 2015, CRIT CARE MED, V43, pE241, DOI 10.1097/CCM.0000000000000999
   Kanso H, 2014, INT DAIRY J, V39, P113, DOI 10.1016/j.idairyj.2014.05.004
   Kim B, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081816
   Kim GW, 2014, CLIN PHARMACOL THER, V95, P53, DOI 10.1038/clpt.2013.204
   La Russa D, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8030066
   Li P, 2015, MOL MED REP, V12, P7116, DOI 10.3892/mmr.2015.4315
   Lima-Leopoldo AP, 2011, ARQ BRAS CARDIOL, V97, P232, DOI 10.1590/S0066-782X2011005000061
   Lyoussi B, 2018, CLIN EXP HYPERTENS, V40, P353, DOI 10.1080/10641963.2017.1377219
   Mallat RK, 2017, CRIT REV CL LAB SCI, V54, P458, DOI 10.1080/10408363.2017.1394267
   Manolis AJ, 2014, CURR VASC PHARMACOL, V12, P4
   Matthews VB, 2018, INT J ENDOCRINOL, V2018, DOI 10.1155/2018/7969750
   Miesel A, 2010, ANN NUTR METAB, V56, P127, DOI 10.1159/000278748
   Mitschke MM, 2013, FASEB J, V27, P1621, DOI 10.1096/fj.12-221580
   Nevelsteen I, 2013, BMC CARDIOVASC DISOR, V13, DOI 10.1186/1471-2261-13-51
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Oliveira SA, 2010, MED SCI MONITOR, V16, pBR367
   Oron-Herman M, 2008, AM J HYPERTENS, V21, P1018, DOI 10.1038/ajh.2008.218
   Oudot A, 2010, J SEX MED, V7, P79, DOI 10.1111/j.1743-6109.2009.01551.x
   Potenza MA, 2005, AM J PHYSIOL-HEART C, V289, pH813, DOI 10.1152/ajpheart.00092.2005
   Priviero FBM, 2009, AM J HYPERTENS, V22, P493, DOI 10.1038/ajh.2009.18
   REAVEN GM, 1991, AM J HYPERTENS, V4, P34, DOI 10.1093/ajh/4.1.34
   Sauvaget F, 2010, EUR J PHARMACOL, V644, P169, DOI 10.1016/j.ejphar.2010.07.003
   Shayo SC, 2019, DIABETES METAB SYND, V13, P2164, DOI 10.1016/j.dsx.2019.05.005
   Silva JF, 2016, FRONT PHYSIOL, V7, DOI 10.3389/fphys.2016.00386
   Skrzypiec-Spring Monika, 2007, Journal of Pharmacological and Toxicological Methods, V55, P113, DOI 10.1016/j.vascn.2006.05.006
   Stasch JP, 2001, NATURE, V410, P212, DOI 10.1038/35065611
   Thorin C, 2010, J PHARM PHARMACOL, V62, P339, DOI 10.1211/jpp.62.03.0008
   Thorp AA, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/341583
   Tobin JV, 2018, J PHARMACOL EXP THER, V365, P664, DOI 10.1124/jpet.117.247429
   Ferron AJT, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8090368
   Tune JD, 2017, TRANSL RES, V183, P57, DOI 10.1016/j.trsl.2017.01.001
   Vendrame S, 2014, APPL PHYSIOL NUTR ME, V39, P255, DOI 10.1139/apnm-2013-0249
   Yu J, 2016, PHYSIOL RES, V65, P209, DOI 10.33549/physiolres.933007
   Zhao CY, 2015, J MOL CELL CARDIOL, V88, P29, DOI 10.1016/j.yjmcc.2015.09.011
NR 54
TC 4
Z9 4
U1 0
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD MAY 15
PY 2021
VL 899
AR 173978.
DI 10.1016/j.ejphar.2021.173978
EA MAR 2021
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA RO9SI
UT WOS:000641378500009
PM 33691164
OA Green Published
DA 2025-06-11
ER

PT J
AU Lasserre, AM
   Strippoli, MPF
   Glaus, J
   Gholam-Rezaee, M
   Vandeleur, CL
   Castelao, E
   Marques-Vidal, P
   Waeber, G
   Vollenweider, P
   Preisig, M
AF Lasserre, A. M.
   Strippoli, M-P F.
   Glaus, J.
   Gholam-Rezaee, M.
   Vandeleur, C. L.
   Castelao, E.
   Marques-Vidal, P.
   Waeber, G.
   Vollenweider, P.
   Preisig, M.
TI Prospective associations of depression subtypes with cardio-metabolic
   risk factors in the general population
SO MOLECULAR PSYCHIATRY
LA English
DT Article
ID TYPE-2 DIABETES-MELLITUS; MAJOR DEPRESSION; DIAGNOSTIC INTERVIEW;
   CARDIOVASCULAR-DISEASE; ATYPICAL FEATURES; DISORDERS; METAANALYSIS;
   CYTOKINES; PREDICTS; OBESITY
AB The mechanisms and temporal sequence underlying the association between major depressive disorder (MDD) and cardio-metabolic diseases are still poorly understood. Recent research suggests subtyping depression to study the mechanisms underlying its association with biological correlates. Accordingly, our aims were to (1) assess the prospective associations of the atypical, melancholic and unspecified subtypes of MDD with changes of fasting glucose, high-density lipoprotein-cholesterol, triglycerides, systolic blood pressure and the incidence of the metabolic syndrome, (2) determine the potential mediating role of inflammatory marker or adipokine concentrations, eating behaviors and changes in waist circumference during follow-up. Data stemmed from CoLaus|PsyCoLaus, a prospective cohort study including 35-66-year-old randomly selected residents of an urban area. Among the Caucasian participants who underwent the physical and psychiatric baseline evaluations, 2813 (87% participation rate) also accepted the physical follow-up exam (mean follow-up duration = 5.5 years). Symptoms of mental disorders were elicited using a semi-structured interview. The atypical MDD subtype, and only this subtype, was prospectively associated with a higher incidence of the metabolic syndrome (OR = 2.49; 95% CI 1.30-4.77), a steeper increase of waist circumference (beta = 2.41; 95% CI 1.19-3.63) and independently of this, with a steeper increase of the fasting glucose level (beta = 131; 95% CI 38-225) during follow-up. These associations were not attributable to or mediated by inflammatory marker or adipokine concentrations, eating behaviors, comorbid psychiatric disorders or lifestyle factors. Accordingly, our results further support the subtyping of MDD and highlight the particular need for prevention and treatment of metabolic consequences in patients with atypical MDD.
C1 [Lasserre, A. M.; Strippoli, M-P F.; Glaus, J.; Gholam-Rezaee, M.; Vandeleur, C. L.; Castelao, E.; Preisig, M.] Lausanne Univ Hosp, Dept Psychiat, Ctr Psychiat Epidemiol & Psychopathol, Prilly, Switzerland.
   [Glaus, J.] NIMH, Genet Epidemiol Res Branch, Intramural Res Program, Bethesda, MD 20892 USA.
   [Marques-Vidal, P.; Waeber, G.; Vollenweider, P.] Lausanne Univ Hosp, Dept Internal Med, Lausanne, Switzerland.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Mental Health (NIMH); University of Lausanne; Centre Hospitalier
   Universitaire Vaudois (CHUV)
RP Lasserre, AM (corresponding author), Univ Lausanne, Dept Psychiat, Ctr Psychiat Epidemiol & Psychopathol, Site Cery, CH-1008 Lausanne, Prilly, Switzerland.
EM Aurelie.Lasserre@chuv.ch
RI Glaus, Jennifer/C-7887-2017; Preisig, Martin/H-3441-2016; Lasserre,
   Aurelie M/AEA-0456-2022; Marques-Vidal, Pedro/C-9449-2009; Vollenweider,
   Peter/Q-4603-2016
OI Lasserre, Aurelie M/0000-0003-3925-6663; Marques-Vidal,
   Pedro/0000-0002-4548-8500; Glaus, Jennifer/0000-0001-8883-9473;
   Castelao, Enrique/0000-0003-1966-3683; Vollenweider,
   Peter/0000-0002-0765-896X; Preisig, Martin/0000-0001-5689-4259;
   Vandeleur, Caroline/0000-0001-9092-6648; Waeber,
   Gerard/0000-0003-4193-788X; Strippoli, Marie-Pierre/0000-0003-3053-484X
FU GlaxoSmithKline; Faculty of Biology and Medicine of Lausanne; Swiss
   National Science Foundation [3200B0-105993, 3200B0-118308,
   33CSCO-122661, 33CS30-139468, 33CS30-148401, 323530_151479]; Swiss
   National Science Foundation (SNF) [323530_151479] Funding Source: Swiss
   National Science Foundation (SNF)
FX We express our gratitude to the Lausanne inhabitants who volunteered to
   participate in the CoLaus vertical bar PsyCoLaus study. We thank all the
   investigators of the study. The CoLaus vertical bar PsyCoLaus study was
   and is supported by research grants from GlaxoSmithKline, the Faculty of
   Biology and Medicine of Lausanne, and the Swiss National Science
   Foundation (grants 3200B0-105993, 3200B0-118308, 33CSCO-122661,
   33CS30-139468 and 33CS30-148401). Aurelie Lasserre is supported by a
   grant from the Swiss National Science Foundation (grant 323530_151479).
CR [Anonymous], COMPENDIUM SUISSE ME
   [Anonymous], 2000, Diagnostic and Statistical Manual of Mental Disorders, VFourth, P943, DOI DOI 10.1002/JPS.3080051129
   [Anonymous], HEALTHC SER
   Antonijevic IA, 2006, PSYCHONEUROENDOCRINO, V31, P1, DOI 10.1016/j.psyneuen.2005.04.004
   Baune BT, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.18
   Baune BT, 2012, GEN HOSP PSYCHIAT, V34, P478, DOI 10.1016/j.genhosppsych.2012.05.013
   Beer-Borst S, 2009, EUR J CLIN NUTR, V63, P155, DOI 10.1038/sj.ejcn.1602922
   Bernstein L, 1995, Sante Publique, V7, P403
   Bot M, 2015, BIOL PSYCHIAT, V77, DOI 10.1016/j.biopsych.2015.10.023
   Cizza G, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0028912
   Clair C, 2013, JAMA-J AM MED ASSOC, V309, P1014, DOI 10.1001/jama.2013.1644
   ENDICOTT J, 1978, ARCH GEN PSYCHIAT, V35, P837
   Firmann M, 2008, BMC CARDIOVASC DISOR, V8, DOI 10.1186/1471-2261-8-6
   Ghaemi SN, 2011, ACTA PSYCHIAT SCAND, V124, P497, DOI 10.1111/j.1600-0447.2011.01746.x
   Glaus J, 2013, ACTA PSYCHIAT SCAND, V128, P282, DOI 10.1111/acps.12057
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Harald B, 2012, J AFFECT DISORDERS, V139, P126, DOI 10.1016/j.jad.2011.07.015
   Hollingshead A., 2011, Four factor index of social status, V8, P21
   HUBER PJ, 1973, ANN STAT, V1, P799, DOI 10.1214/aos/1176342503
   Huffman Jeff C, 2013, Cardiovasc Psychiatry Neurol, V2013, P695925, DOI 10.1155/2013/695925
   Kaestner F, 2005, J AFFECT DISORDERS, V87, P305, DOI 10.1016/j.jad.2005.03.012
   Knol MJ, 2006, DIABETOLOGIA, V49, P837, DOI 10.1007/s00125-006-0159-x
   Kop WJ, 2010, PSYCHOSOM MED, V72, P626, DOI 10.1097/PSY.0b013e3181eadd2b
   Lamers F, 2016, BRIT J PSYCHIAT, V208, P62, DOI 10.1192/bjp.bp.114.153098
   Lamers F, 2013, MOL PSYCHIATR, V18, P692, DOI 10.1038/mp.2012.144
   Lasserre AM, 2014, JAMA PSYCHIAT, V71, P880, DOI 10.1001/jamapsychiatry.2014.411
   Licht CMM, 2013, J CLIN ENDOCR METAB, V98, P2484, DOI 10.1210/jc.2012-3104
   Lu XY, 2007, CURR OPIN PHARMACOL, V7, P648, DOI 10.1016/j.coph.2007.10.010
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Marques-Vidal P, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0021002
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Milaneschi Y, 2014, MOL PSYCHIATR, V19, P960, DOI 10.1038/mp.2014.4
   Morin AJS, 2011, REV EPIDEMIOL SANTE, V59, P327, DOI 10.1016/j.respe.2011.03.061
   Nicholson A, 2006, EUR HEART J, V27, P2763, DOI 10.1093/eurheartj/ehl338
   Nouwen A, 2010, DIABETOLOGIA, V53, P2480, DOI 10.1007/s00125-010-1874-x
   NURNBERGER JI, 1994, ARCH GEN PSYCHIAT, V51, P849, DOI 10.1001/archpsyc.1994.03950110009002
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Penninx BWJH, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-129
   Preisig M, 1999, EUR ARCH PSY CLIN N, V249, P174, DOI 10.1007/s004060050084
   Preisig M, 2009, BMC PSYCHIATRY, V9, DOI 10.1186/1471-244X-9-9
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Rivera M, 2012, MOL PSYCHIATR, V17, P604, DOI 10.1038/mp.2011.45
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Rudolf S, 2014, PSYCHIAT RES, V217, P34, DOI 10.1016/j.psychres.2014.02.016
   Samaan Z, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.113
   Scherrer JF, 2011, TWIN RES HUM GENET, V14, P169, DOI 10.1375/twin.14.2.169
   Scott David, 2011, Issues Ment Health Nurs, V32, P589, DOI 10.3109/01612840.2011.569846
   Takeuchi T, 2013, PSYCHIAT CLIN NEUROS, V67, P532, DOI 10.1111/pcn.12104
   Van der Kooy K, 2007, INT J GERIATR PSYCH, V22, P613, DOI 10.1002/gps.1723
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vogelzangs N, 2014, BRAIN BEHAV IMMUN, V41, P109, DOI 10.1016/j.bbi.2014.05.004
   Yoon HK, 2012, NORD J PSYCHIAT, V66, P183, DOI 10.3109/08039488.2011.611894
NR 54
TC 83
Z9 85
U1 0
U2 12
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD JUL
PY 2017
VL 22
IS 7
BP 1026
EP 1034
DI 10.1038/mp.2016.178
PG 9
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA EY3YK
UT WOS:000403911900011
PM 27725658
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kim, JH
   Kim, HL
   Battushig, B
   Yoo, JY
AF Kim, Jin Hee
   Kim, Hyun Lye
   Battushig, Bolorchimeg
   Yoo, Jae Yong
TI Relationship between socio-demographics, body composition, emotional
   state, and social support on metabolic syndrome risk among adults in
   rural Mongolia
SO PLOS ONE
LA English
DT Article
ID NUTRITION EXAMINATION SURVEY; KOREAN NATIONAL-HEALTH; UNITED-STATES;
   OBESITY; PREVALENCE; ASSOCIATION; DEFINITION; PREVENTION; DEPRESSION;
   TRENDS
AB Background In Mongolia, where there is a large regional gap in the quality of healthcare services, metabolic syndrome (MetS) is steadily increasing. However, there are few studies on the risk level of MetS and affecting factors among adults living in rural Mongolia. This study aims to explore the relationship between socio-demographics, clinical characteristics, emotional state, and social support on the risk level of MetS prevalence among adults living in rural Mongolia. Methods In this cross-sectional study, 143 adults living in the soum area of Dondgovi aimag in Mongolia were recruited. Data collection was conducted from July 2 to 3, 2019. The self-reported questionnaires including socio-demographic, clinical characteristics and emotional status, anthropometric tests using the InBody, and blood sampling tests were conducted. The number of individual diagnostic criteria met was scored as a MetS risk score and classified into 6 groups, from the lowest score of 0 to the highest score of 5. The ordinal logistic regression analysis was used to identify the factors affecting the risk of MetS. Results The prevalence of MetS among adults living in rural Mongolia was 58.0%, and the mean MetS risk score was 2.70 +/- 1.34 points. In the ordinal logistic regression analysis, age, regular exercise of moderate intensity or higher, InBody score reflecting obesity or sarcopenia, and depression level were statistically significantly associated with the risk score for MetS. Conclusions Our study demonstrated that MetS risk levels among adults living in rural Mongolia with limited medical resources were strongly associated with demographic characteristics, body composition and emotional health condition, particularly depression.
C1 [Kim, Jin Hee; Kim, Hyun Lye; Yoo, Jae Yong] Chosun Univ, Dept Nursing, Coll Med, Gwangju, South Korea.
   [Battushig, Bolorchimeg] Mongolian Natl Univ, Sch Med, Dept Nursing, Ulaanbaatar, Mongolia.
C3 Chosun University; National University of Mongolia
RP Yoo, JY (corresponding author), Chosun Univ, Dept Nursing, Coll Med, Gwangju, South Korea.
EM jaeyongyoo@chosun.ac.kr
RI kim, jong-eun/B-3550-2017; KIM, SEON-OK/HGC-7012-2022
OI YOO, JAEYONG/0000-0002-1212-5121; Kim, Jinhee/0000-0002-8037-9174
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Beltrán-Sánchez H, 2013, J AM COLL CARDIOL, V62, P697, DOI 10.1016/j.jacc.2013.05.064
   Cardel MI, 2017, FASEB J, V31
   Cho KI, 2016, BIOMED RES INT, V2016, DOI 10.1155/2016/3973197
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Dietz WH, 2015, LANCET, V385, P2521, DOI 10.1016/S0140-6736(14)61748-7
   Donato KA, 1998, ARCH INTERN MED, V158, P1855, DOI 10.1001/archinte.158.17.1855
   Dorjdagva J, 2017, INT J EQUITY HEALTH, V16, DOI 10.1186/s12939-017-0572-4
   Enkh-Oyun T, 2015, METAB SYNDR RELAT D, V13, P179, DOI 10.1089/met.2014.0067
   Eom JY., 2009, THESIS DONGDUK WOMEN
   Friel S, 2015, ASIA PAC POLICY STU, V2, P324, DOI 10.1002/app5.89
   Hanushek E.A., 2013, Statistical methods for social scientists
   Hong AR, 2015, J DIABETES INVEST, V6, P508, DOI 10.1111/jdi.12313
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   James PT, 2004, EUR J CARDIOV PREV R, V11, P3, DOI 10.1097/01.hjr.0000114707.27531.48
   전상남, 2014, [Journal of the Korea Gerontological Society, 한국노년학], V34, P87
   Kim CK, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15051020
   Kim H, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17093008
   Korea Centers for Disease Control and Prevention, KOR NAT HLTH NUTR EX
   Korea Health Industry Development Institute, 2015, HEALTHC STAT MONG
   Lee Jihye, 2016, J Prev Med Public Health, V49, P35, DOI 10.3961/jpmph.15.055
   Lee SE, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194490
   Li EF, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0152273
   Li YR, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0199293
   Lim S, 2011, DIABETES CARE, V34, P1323, DOI 10.2337/dc10-2109
   Lim S, 2010, DIABETES CARE, V33, P1652, DOI 10.2337/dc10-0107
   Lu CW, 2013, OBES RES CLIN PRACT, V7, pE301, DOI 10.1016/j.orcp.2012.02.003
   Misra A, 2008, J CLIN ENDOCR METAB, V93, pS9, DOI 10.1210/jc.2008-1595
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Neumann N, 2015, CENT ASIAN J MED SCI, V1, P16
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Park H, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17165629
   Park J.W., 1985, A study to develop a scale of social support
   Park SJ, 2016, J AFFECT DISORDERS, V205, P393, DOI 10.1016/j.jad.2016.08.022
   Park S, 2008, J GERONTOL A-BIOL, V63, P1119, DOI 10.1093/gerona/63.10.1119
   Pérez-Martínez P, 2017, NUTR REV, V75, P307, DOI 10.1093/nutrit/nux014
   Ranasinghe P, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4041-1
   Razzouk L, 2009, CURR HYPERTENS REP, V11, P127, DOI 10.1007/s11906-009-0023-8
   Repousi N, 2018, J AFFECT DISORDERS, V237, P56, DOI 10.1016/j.jad.2018.04.102
   Scuteri A, 2015, EUR J PREV CARDIOL, V22, P486, DOI 10.1177/2047487314525529
   Shin D, 2018, INT J CARDIOL, V259, P216, DOI 10.1016/j.ijcard.2018.01.139
   Spitzer RL, 1999, JAMA-J AM MED ASSOC, V282, P1737, DOI 10.1001/jama.282.18.1737
   Stenholm S, 2008, CURR OPIN CLIN NUTR, V11, P693, DOI 10.1097/MCO.0b013e328312c37d
   Sugimoto Toshitsugu, 2016, Value Health Reg Issues, V9, P49, DOI 10.1016/j.vhri.2015.09.005
   Sun K, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047791
   The Secretariat of the State Great Hural of Mongolia, 2016, MONG SUST DEV VIS 20
   Tsushita K, 2018, J ATHEROSCLER THROMB, V25, P308, DOI 10.5551/jat.42010
   Wang XM, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16020169
   Wannamethee SG, 2015, P NUTR SOC, V74, P405, DOI 10.1017/S002966511500169X
   World Health Organization, 2016, GLOB HLTH OBS DAT RE
   World Health Organization (WHO). Regional Office for the Western Pacific, 2013, MONG HLTH SYST REV
   Yu Hye-Young, 2017, [Journal of Korean Geriatric Psychiatry, 노인정신의학], V21, P75
   Zheng RZ, 2015, INT J ENV RES PUB HE, V12, P13662, DOI 10.3390/ijerph121113662
NR 54
TC 5
Z9 5
U1 0
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PY 2021
VL 16
IS 9
AR e0254141
DI 10.1371/journal.pone.0254141
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA XM7DR
UT WOS:000728983400034
PM 34570786
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Perez, I
   Hafidi, M
   Carvajal, K
   Baños, G
AF Perez, Israel
   Hafidi, Mohammed El
   Carvajal, Karla
   Banos, Guadalupe
TI Castration modifies aortic vasoreactivity and serum fatty acids in a
   sucrose-fed rat model of metabolic syndrome
SO HEART AND VESSELS
LA English
DT Article
DE Rat metabolic syndrome; Castration; Vascular reactivity; Free fatty
   acids
ID ENDOTHELIUM-DEPENDENT VASODILATION; SUGAR-INDUCED HYPERTENSION;
   SPRAGUE-DAWLEY RATS; BLOOD-PRESSURE; VASCULAR REACTIVITY; SEX-HORMONES;
   INSULIN-RESISTANCE; TESTOSTERONE; HYPERTRIGLYCERIDEMIA; ANDROGENS
AB Levels of testosterone and estradiol influence the incidence of cardiovascular diseases: generally, estrogens in females are protective before menopause; coronaropathies, hypertension, and dyslipidemias in normal men are more frequent at comparable ages. We investigated the modulation by castration of in vitro vasoreactivity, serum lipid content, and systolic blood pressure (SBP) in rats with sucrose-induced metabolic syndrome. The main characteristics of the rat model are: hypertriglyceridemia, moderately high blood pressure, intra-abdominal accumulation of adipose tissue, hyperinsulinemia, nephropathy, increased oxidative stress, and altered vasoreactivity. Male weanling rats received 30% sucrose solution for 16 weeks (metabolic syndrome; MS), controls (C) had plain water; both had commercial rodent chow. They were subdivided into five groups with two subgroups each: Group 1, intact C and MS rats, Groups 2-5, C and MS rats castrated for periods of 16, 12, 8, and 4 weeks. At the end of the study period, systolic blood pressure was measured, and blood and aortas were obtained for fatty acid determination and vasoreactivity assays, respectively. After 16 weeks' sucrose treatment MS aortas showed hypercontractility and decreased vasodilation. Palmitic and palmitoleic acids were increased in MS versus C. Arachidonic acid levels in MS were lower than in intact or castrated C. Long-term castration of 16 weeks normalized the levels of palmitic and oleic acids. With the shorter periods of castration, contractility increased and relaxation decreased in C and MS, but it was more significant in C. Regarding fatty acid composition, long-term castration increased polyunsaturated (arachidonic and eicosapentaenoic) fatty acids. The shorter periods did not modify the fatty acid profile in either C or MS. Metabolic syndrome altered SBP, aortic reactivity, and levels of fatty acids; castration of long duration normalized them in some cases.
C1 [Hafidi, Mohammed El; Carvajal, Karla; Banos, Guadalupe] Inst Nacl Cardiol Ignacio Chavez, Dept Biochem, Mexico City 14080, DF, Mexico.
   [Perez, Israel] Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Mexico City 14080, DF, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico
RP Baños, G (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Biochem, Juan Badiano 1,Tlalpan Col Secc 16, Mexico City 14080, DF, Mexico.
EM gbanos@yahoo.com
RI Pérez Torres, Israel/AAE-2579-2022
OI Perez-Torres, Israel/0000-0001-6510-2954; CARVAJAL,
   KARLA/0000-0002-5522-3266
FU National Council for Science and Technology (CONACyT) [3210-PM, 43229-M]
FX This work was partially supported by Grant Nos. 3210-PM and 43229-M from
   the National Council for Science and Technology (CONACyT) to G. B. and
   were the only sources of funding.
CR Banos G, 1997, AM J HYPERTENS, V10, P379
   Bojesen A, 2006, DIABETES CARE, V29, P1591, DOI 10.2337/dc06-0145
   Bowles DK, 2004, AM J PHYSIOL-HEART C, V287, pH2091, DOI 10.1152/ajpheart.00258.2004
   CAMICI PG, 1994, CARDIOVASC DRUG THER, V8, P221, DOI 10.1007/BF00877330
   de Kreutzenberg SV, 2000, J CLIN ENDOCR METAB, V85, P793, DOI 10.1210/jc.85.2.793
   DRAGO F, 1982, BIOL REPROD, V27, P765, DOI 10.1095/biolreprod27.4.765
   Dubey RK, 2002, CARDIOVASC RES, V53, P688, DOI 10.1016/S0008-6363(01)00527-2
   El Hafidi M, 2001, J NUTR BIOCHEM, V12, P396, DOI 10.1016/S0955-2863(01)00154-1
   El Hafidi M, 2000, CLIN EXP HYPERTENS, V22, P99
   El Hafidi M, 2006, CLIN EXP HYPERTENS, V28, P669, DOI 10.1080/10641960601013617
   ElHafidi M, 1997, HYPERTENSION, V30, P624, DOI 10.1161/01.HYP.30.3.624
   FISCHER GM, 1977, AM J PHYSIOL, V232, pH617, DOI 10.1152/ajpheart.1977.232.6.H617
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   Freitas RRDA, 2007, AM J HYPERTENS, V20, P692, DOI 10.1016/j.amjhyper.2007.01.014
   Frisbee JC, 2004, J APPL PHYSIOL, V97, P764, DOI 10.1152/japplphysiol.01216.2003
   Fujii N, 2008, HEART VESSELS, V23, P9, DOI 10.1007/s00380-007-1002-0
   Galipeau D, 2002, AM J PHYSIOL-HEART C, V283, pH2478, DOI 10.1152/ajpheart.00243.2002
   GREKIN RJ, 1995, HYPERTENSION, V26, P193, DOI 10.1161/01.HYP.26.1.193
   Grisk O, 2007, PFLUG ARCH EUR J PHY, V454, P1011, DOI 10.1007/s00424-007-0267-6
   HULMAN S, 1994, PEDIATR RES, V36, P95, DOI 10.1203/00006450-199407001-00017
   HWANG IS, 1987, HYPERTENSION, V10, P512, DOI 10.1161/01.HYP.10.5.512
   Iliescu R, 2006, CLIN SCI, V111, P251, DOI 10.1042/CS20060102
   Jones RD, 2004, EUR J ENDOCRINOL, V151, P29, DOI 10.1530/eje.0.1510029
   Kotani K, 2007, HEART VESSELS, V22, P291, DOI 10.1007/s00380-006-0969-2
   Maekawa K, 2006, HEART VESSELS, V21, P205, DOI 10.1007/s00380-005-0889-6
   Malkin CJ, 2006, CLIN SCI, V111, P265, DOI 10.1042/CS20050354
   Martin DS, 2005, J HYPERTENS, V23, P2229, DOI 10.1097/01.hjh.0000191903.19230.79
   Miyajima T, 2001, HYPERTENS RES, V24, P537, DOI 10.1291/hypres.24.537
   NAGELE U, 1984, J CLIN CHEM CLIN BIO, V22, P165
   Orshal JM, 2004, AM J PHYSIOL-REG I, V286, pR233, DOI 10.1152/ajpregu.00338.2003
   PAREDESCARBAJAL MC, 1995, LIFE SCI, V57, P473, DOI 10.1016/0024-3205(95)00281-A
   PEIRIS AN, 1989, ANN INTERN MED, V110, P867, DOI 10.7326/0003-4819-110-11-867
   Pérez I, 1999, MED SCI RES, V27, P847
   Pérez Torres I, 2007, LIFE SCI, V80, P2170, DOI 10.1016/j.lfs.2007.04.006
   Perusquía M, 1999, EUR J PHARMACOL, V371, P169, DOI 10.1016/S0014-2999(99)00161-2
   Peters LP, 2003, IN VIVO, V17, P61
   REAVEN GM, 1991, AM J HYPERTENS, V4, P610, DOI 10.1093/ajh/4.7.610
   Reckelhoff JF, 1999, CLIN EXP PHARMACOL P, V26, P127, DOI 10.1046/j.1440-1681.1999.02996.x
   Reckelhoff JF, 2005, HYPERTENSION, V45, P170, DOI 10.1161/01.HYP.0000151825.36598.36
   Simon JA, 1996, HYPERTENSION, V27, P303, DOI 10.1161/01.HYP.27.2.303
   Song DZ, 2004, HYPERTENSION, V43, P667, DOI 10.1161/01.HYP.0000118018.77344.4e
   Steinberg HO, 1997, J CLIN INVEST, V100, P1230, DOI 10.1172/JCI119636
   Steinberg HO, 2000, DIABETES, V49, P1231, DOI 10.2337/diabetes.49.7.1231
   Vermunt S H F, 2003, Obes Rev, V4, P91
NR 44
TC 12
Z9 13
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0910-8327
EI 1615-2573
J9 HEART VESSELS
JI Heart Vessels
PD MAR
PY 2009
VL 24
IS 2
BP 147
EP 155
DI 10.1007/s00380-008-1098-x
PG 9
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 428GM
UT WOS:000264836000013
PM 19337800
DA 2025-06-11
ER

PT J
AU Khodavirdipour, A
   Haddadi, F
   Keshavarzi, S
AF Khodavirdipour, Amir
   Haddadi, Fatemeh
   Keshavarzi, Shiva
TI Chromium Supplementation; Negotiation with Diabetes Mellitus,
   Hyperlipidemia and Depression
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Review
DE Chromium; Cancer; Cardiovascular disease; Depression; Diabetes Mellitus;
   Hyperlipidaemia; Trace Elements
ID ACTIVATED PROTEIN-KINASE; HIGH-DENSITY-LIPOPROTEIN; GLUCOSE-TOLERANCE;
   SERUM-LIPIDS; GLYCEMIC CONTROL; PICOLINATE SUPPLEMENTATION;
   MOLECULAR-MECHANISMS; INSULIN SENSITIVITY; INORGANIC CHROMIUM;
   BODY-COMPOSITION
AB Chromium (Cr) is an essential trace element which found naturally in a daily diet and available in the form of supplementary tablets to boost disorders like diabetes mellitus (DM) and functions like lipid metabolism and beneficial on depression too. Diabetes is one of the most prevalent endocrine diseases or in other words, the most severe metabolic syndrome (MS), which associated with high production of free-radicals which is out of bodies detoxifying machine capacity or high oxidative stress (HOS), vasculitis and elevated lipid profile. many research papers and clinical trials published about the significance of chromium on biological activities, pre and post clinical. For this review research articles, clinical trials, from 1(st) Jan'10 to 31(st) Dec'18 and refer literature for the biochemical, pharmacological and biological activity of Chromium. Primarily articles gathered from the above search engines. Then precisely according to our aim and goal and regarding designed objectives dismisses similar articles and finally came to 84 articles for the above said period. This review trying to cover the entire picture from what chromium is to the recent updates on their greater role in increasing insulin sensitivity of cells and enhancing lipid metabolism and even recent findings suggest its positive effects including prevention and ameliorating properties on depression. The biological activities, pharmacological features, clinical implications including efficacy and role of chromium compounds on the glycaemic index will be discussed. The outcome of this review is to bring the pros and cons of chromium supplementation along with is safety and toxicity concern beside molecular pathways, biochemistry and clinical trials, all in one comprehensive review.
C1 [Khodavirdipour, Amir] St Johns Hosp, Div Human Genet, Dept Anat, Bangalore, Karnataka, India.
   [Khodavirdipour, Amir] Univ Tabriz, Dept Biol, Fac Nat Sci, Tabriz 9861335856, Iran.
   [Haddadi, Fatemeh; Keshavarzi, Shiva] Univ Zabol, Dept Biol, Fac Sci, Zabol, Iran.
C3 University of Tabriz
RP Haddadi, F (corresponding author), Univ Zabol, Dept Biol, Fac Sci, Zabol, Iran.
EM haddadifatemeh@yahoo.com
RI Khodavirdipour, Amir/AAX-1815-2021
CR ABRAHAM AS, 1992, METABOLISM, V41, P768, DOI 10.1016/0026-0495(92)90318-5
   Adam AMA, 2015, SPECTROCHIM ACTA A, V149, P323, DOI 10.1016/j.saa.2015.04.115
   Amann BL, 2007, J CLIN PSYCHOPHARM, V27, P104, DOI 10.1097/JCP.0b013e31802e744b
   Amato P, 2000, J GERONTOL A-BIOL, V55, pM260, DOI 10.1093/gerona/55.5.M260
   ANDERSON RA, 1987, METABOLISM, V36, P351, DOI 10.1016/0026-0495(87)90206-X
   Anderson RA, 2000, DIABETES METAB, V26, P22
   Anderson RA, 1998, J AM COLL NUTR, V17, P548, DOI 10.1080/07315724.1998.10718802
   Anderson RA, 1997, DIABETES, V46, P1786, DOI 10.2337/diabetes.46.11.1786
   [Anonymous], 2018, CHROMIUM DIETARY SUP
   [Anonymous], 2005, FDA APPROVES CHROMIU
   [Anonymous], 1995, FOOD LAB REF DAIL IN, P67164
   [Anonymous], 2016, INT J MOSQ RES
   Attenburrow MJ, 2003, PSYCHOL MED, V33, P1381, DOI 10.1017/S0033291703008547
   Azimi P, 2016, BLOOD PRESSURE, V25, P133, DOI 10.3109/08037051.2015.1111020
   Aziza AK, 2012, CHARACTERIZATION BIO
   Bahijiri SM, 2000, SAUDI MED J, V21, P831
   Balk EM, 2007, DIABETES CARE, V30, P2154, DOI 10.2337/dc06-0996
   Basaki M, 2012, BIOL TRACE ELEM RES, V148, P161, DOI 10.1007/s12011-012-9360-6
   Berner TO, 2004, FOOD CHEM TOXICOL, V42, P1029, DOI 10.1016/j.fct.2004.02.015
   Brownley KA, 2015, MED HYPOTHESES, V85, P45, DOI 10.1016/j.mehy.2015.03.020
   Bury T F, 1988, Ned Tijdschr Geneeskd, V132, P2414
   Cefalu WT, 1999, J TRACE ELEM EXP MED, V12, P71, DOI 10.1002/(SICI)1520-670X(1999)12:2<71::AID-JTRA4>3.0.CO;2-8
   Cefalu WT, 2004, DIABETES CARE, V27, P2741, DOI 10.2337/diacare.27.11.2741
   Cefalu WT, 2003, NEW CLIN STUDY UNCOV
   Chen S H, 1997, Zhongguo Zhong Xi Yi Jie He Za Zhi, V17, P666
   Chen YL, 2014, EUR J NUTR, V53, P127, DOI 10.1007/s00394-013-0508-8
   COLAPINTO ND, 1972, CAN J SURG, V15, P27
   Evans G., 1989, INT J BIOSOCIAL MEDI, V11, P163
   Flegal KM, 2010, JAMA-J AM MED ASSOC, V303, P235, DOI 10.1001/jama.2009.2014
   Ghosh D, 2002, J NUTR BIOCHEM, V13, P690, DOI 10.1016/S0955-2863(02)00220-6
   Glaser E, 1929, BIOCHEM Z, V207, P377
   Grober U, 2004, MED MONATSSCHR PHARM
   Grober Uwe, 2014, Med Monatsschr Pharm, V37, P284
   Hansen AF, 2017, J TRACE ELEM MED BIO, V40, P46, DOI 10.1016/j.jtemb.2016.12.008
   Harani H, 2012, ANN BIOL CLIN-PARIS, V70, P669, DOI 10.1684/abc.2012.0763
   Hardie DG, 2003, FEBS LETT, V546, P113, DOI 10.1016/S0014-5793(03)00560-X
   Hepburn DDD, 2003, J INORG BIOCHEM, V94, P86, DOI 10.1016/S0162-0134(02)00623-2
   Hua Y, 2012, J NUTR BIOCHEM, V23, P313, DOI 10.1016/j.jnutbio.2011.11.001
   Institute of Medicine (IOM), 2004, DIET SUPPL FRAM EV S, pB1
   Jacobs E, 2017, DIABETIC MED, V34, P855, DOI 10.1111/dme.13336
   JEEJEEBHOY KN, 1977, AM J CLIN NUTR, V30, P531
   Jeejeebhoy KN, 1999, NUTR REV, V57, P329, DOI 10.1111/j.1753-4887.1999.tb06909.x
   Kemp BE, 2003, BIOCHEM SOC T, V31, P162
   Koh-Banerjee P, 2004, AM J EPIDEMIOL, V159, P1150, DOI 10.1093/aje/kwh167
   KUDO N, 1995, J BIOL CHEM, V270, P17513, DOI 10.1074/jbc.270.29.17513
   Lang UE, 2015, CELL PHYSIOL BIOCHEM, V37, P1029, DOI 10.1159/000430229
   Lang UE, 2013, CELL PHYSIOL BIOCHEM, V31, P761, DOI 10.1159/000350094
   LEE NA, 1994, DIABETES CARE, V17, P1449, DOI 10.2337/diacare.17.12.1449
   Li Y, 2017, NUTRIENTS, V9, DOI 10.3390/nu9070728
   Liu YJ, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0145315
   McIver DJ, 2015, J NUTR, V145, P2675, DOI 10.3945/jn.115.214569
   Mirfeizi M, 2016, J DIABETES, V8, P647, DOI 10.1111/1753-0407.12342
   Mokdad A. H., 2003, JAMA, Journal of the American Medical Association, V289, P76, DOI 10.1001/jama.289.1.76
   MYNIEC K, 2014, PHARM REP 1, V66, P534, DOI DOI 10.1016/J.PHAREP.2014.03.001
   OFFENBACHER EG, 1980, DIABETES, V29, P919, DOI 10.2337/diabetes.29.11.919
   Ogden CL, 2006, JAMA-J AM MED ASSOC, V295, P1549, DOI 10.1001/jama.295.13.1549
   Paiva AN, 2015, J TRACE ELEM MED BIO, V32, P66, DOI 10.1016/j.jtemb.2015.05.006
   Peruzzu A, 2015, CHEMOSPHERE, V132, P101, DOI 10.1016/j.chemosphere.2015.02.052
   Petersen M, 2003, DIABETES CARE, V26, P917
   Popkin BM, 2010, AM J CLIN NUTR, V91, p284S, DOI 10.3945/ajcn.2009.28473C
   PRESS RI, 1990, WESTERN J MED, V152, P41
   Preuss Harry G., 2000, Journal of Medicine (Westbury), V31, P227
   RABINOWITZ MB, 1983, DIABETES CARE, V6, P319, DOI 10.2337/diacare.6.4.319
   Rains JL, 2011, FREE RADICAL BIO MED, V50, P567, DOI 10.1016/j.freeradbiomed.2010.12.006
   RIALES R, 1981, AM J CLIN NUTR, V34, P2670, DOI 10.1093/ajcn/34.12.2670
   ROEBACK JR, 1991, ANN INTERN MED, V115, P917, DOI 10.7326/0003-4819-115-12-917
   Rotter I, 2015, INT J ENV RES PUB HE, V12, P3944, DOI 10.3390/ijerph120403944
   Rutter GA, 2003, BIOCHEM J, V375, P1, DOI 10.1042/BJ20030048
   San Mauro Martin I, 2016, NUTR HOSP, V33
   SCHWARZ K, 1957, ARCH BIOCHEM BIOPHYS, V72, P515, DOI 10.1016/0003-9861(57)90228-X
   Sharma S, 2011, J TRACE ELEM MED BIO, V25, P149, DOI 10.1016/j.jtemb.2011.03.003
   Simic A, 2017, J TRACE ELEM MED BIO, V41, P91, DOI 10.1016/j.jtemb.2017.03.001
   Suksomboon N, 2014, J CLIN PHARM THER, V39, P292, DOI 10.1111/jcpt.12147
   Sun YJ, 2000, J BIOL INORG CHEM, V5, P129, DOI 10.1007/s007750050016
   Sylvia LG, 2013, PSYCHOTHER PSYCHOSOM, V82, P10, DOI 10.1159/000341309
   UUSITUPA MIJ, 1992, BRIT J NUTR, V68, P209, DOI 10.1079/BJN19920078
   UUSITUPA MIJ, 1983, AM J CLIN NUTR, V38, P404, DOI 10.1093/ajcn/38.3.404
   Vincent JB, 2000, ACCOUNTS CHEM RES, V33, P503, DOI 10.1021/ar990073r
   Volpe SL, 2001, J AM COLL NUTR, V20, P293, DOI 10.1080/07315724.2001.10719050
   Wasser WG, 1997, ANN INTERN MED, V126, P410, DOI 10.7326/0003-4819-126-5-199703010-00019
   Whitfield P, 2016, EUR J NUTR, V55, P1123, DOI 10.1007/s00394-015-0926-x
   Wilbur S, 2000, TXB TOXICOLOGICAL PR
   WILSON BE, 1995, DIABETES RES CLIN PR, V28, P179, DOI 10.1016/0168-8227(95)01097-W
   Winder WW, 1996, AM J PHYSIOL-ENDOC M, V270, pE299, DOI 10.1152/ajpendo.1996.270.2.E299
   Yechoor VK, 2004, P NATL ACAD SCI USA, V101, P16525, DOI 10.1073/pnas.0407574101
   Yeghiazaryan Kristina, 2012, Infectious Disorders - Drug Targets, V12, P332
NR 86
TC 29
Z9 30
U1 3
U2 36
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD JUN
PY 2020
VL 19
IS 1
BP 585
EP 595
DI 10.1007/s40200-020-00501-8
PG 11
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA NR3GL
UT WOS:000571450700066
PM 32550211
OA Green Published
DA 2025-06-11
ER

PT J
AU Sato, A
   Yumita, Y
   Kagami, K
   Ishinoda, Y
   Kimura, T
   Osaki, A
   Toya, T
   Namba, T
   Endo, S
   Ido, Y
   Nagatomo, Y
   Satoh, Y
   Adachi, T
AF Sato, Atsushi
   Yumita, Yusuke
   Kagami, Kazuki
   Ishinoda, Yuki
   Kimura, Toyokazu
   Osaki, Ayumu
   Toya, Takumi
   Namba, Takayuki
   Endo, Shogo
   Ido, Yasuo
   Nagatomo, Yuji
   Satoh, Yasushi
   Adachi, Takeshi
TI Endothelial Extracellular Signal-Regulated Kinase/Thromboxane
   A2/Prostanoid Receptor Pathway Aggravates Endothelial Dysfunction and
   Insulin Resistance in a Mouse Model of Metabolic Syndrome
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE endothelium; extracellular signal-regulated kinase 2; hypertension;
   insulin resistance; metabolic syndrome
ID NITRIC-OXIDE SYNTHASE; THROMBOXANE A(2); ANGIOTENSIN-II;
   CARDIOVASCULAR-DISEASE; S-GLUTATHIOLATION; OXIDATIVE STRESS;
   BLOOD-PRESSURE; CONTRIBUTES; ANTAGONIST; ACTIVATION
AB BackgroundMetabolic syndrome is characterized by insulin resistance, which impairs intracellular signaling pathways and endothelial NO bioactivity, leading to cardiovascular complications. Extracellular signal-regulated kinase (ERK) is a major component of insulin signaling cascades that can be activated by many vasoactive peptides, hormones, and cytokines that are elevated in metabolic syndrome. The aim of this study was to clarify the role of endothelial ERK2 in vivo on NO bioactivity and insulin resistance in a mouse model of metabolic syndrome. Methods and ResultsControl and endothelial-specific ERK2 knockout mice were fed a high-fat/high-sucrose diet (HFHSD) for 24 weeks. Systolic blood pressure, endothelial function, and glucose metabolism were investigated. Systolic blood pressure was lowered with increased NO products and decreased thromboxane A2/prostanoid (TP) products in HFHSD-fed ERK2 knockout mice, and N omega-nitro-l-arginine methyl ester (L-NAME) increased it to the levels observed in HFHSD-fed controls. Acetylcholine-induced relaxation of aortic rings was increased, and aortic superoxide level was lowered in HFHSD-fed ERK2 knockout mice. S18886, an antagonist of the TP receptor, improved endothelial function and decreased superoxide level only in the rings from HFHSD-fed controls. Glucose intolerance and the impaired insulin sensitivity were blunted in HFHSD-fed ERK2 knockout mice without changes in body weight. In vivo, S18886 improved endothelial dysfunction, systolic blood pressure, fasting serum glucose and insulin levels, and suppressed nonalcoholic fatty liver disease scores only in HFHSD-fed controls. ConclusionsEndothelial ERK2 increased superoxide level and decreased NO bioactivity, resulting in the deterioration of endothelial function, insulin resistance, and steatohepatitis, which were improved by a TP receptor antagonist, in a mouse model of metabolic syndrome.
C1 [Sato, Atsushi; Yumita, Yusuke; Kagami, Kazuki; Ishinoda, Yuki; Kimura, Toyokazu; Osaki, Ayumu; Toya, Takumi; Namba, Takayuki; Ido, Yasuo; Nagatomo, Yuji; Adachi, Takeshi] Natl Def Med Coll, Dept Cardiol, Tokorozawa, Japan.
   [Satoh, Yasushi] Natl Def Med Coll, Dept Biochem, Tokorozawa, Japan.
   [Endo, Shogo] Tokyo Metropolitan Inst Gerontol, Dept Aging Neurosci, Tokyo, Japan.
   [Adachi, Takeshi] Natl Def Med Coll, Dept Internal Med 1, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan.
C3 National Defense Medical College - Japan; National Defense Medical
   College - Japan; Tokyo Metropolitan Institute of Gerontology; National
   Defense Medical College - Japan
RP Adachi, T (corresponding author), Natl Def Med Coll, Dept Internal Med 1, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan.
EM tadachibu@gmail.com
RI Nagatomo, Yuji/AAQ-1590-2020; Yumita, Yusuke/GXH-7782-2022; Endo,
   Shogo/LKJ-5968-2024
OI KAGAMI, KAZUKI/0000-0002-1743-4409; Toya, Takumi/0000-0002-4681-2798;
   sato, atsushi/0000-0002-2138-3173; Nagatomo, Yuji/0000-0002-3430-4614;
   Yumita, Yusuke/0000-0002-0186-5968; Endo, Shogo/0000-0002-3948-8723;
   Ishinoda, Yuki/0000-0002-7477-8638
FU Ministry of Defense;  [18H02815];  [18K08120];  [17K09565];  [17K09596];
   Grants-in-Aid for Scientific Research [21K19752] Funding Source: KAKEN
FX This work was supported by a Grant-in-Aid for Scientific Research (B)
   (18H02815) and Scientific Research (C) (numbers 18K08120, 17K09565, and
   17K09596) and a Grant-in-Aid from the Ministry of Defense.
CR Adachi T, 2004, J BIOL CHEM, V279, P29857, DOI 10.1074/jbc.M313320200
   AISAKA K, 1989, BIOCHEM BIOPH RES CO, V160, P881, DOI 10.1016/0006-291X(89)92517-5
   Andreozzi F, 2004, CIRC RES, V94, P1211, DOI 10.1161/01.RES.0000126501.34994.96
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Clavreul N, 2006, FASEB J, V20, P518, DOI 10.1096/fj.05-4875fje
   Ding LL, 2007, AM J PHYSIOL-HEART C, V292, pH2997, DOI 10.1152/ajpheart.00388.2006
   Dong YF, 2010, DIABETOLOGIA, V53, P180, DOI 10.1007/s00125-009-1575-5
   Du JJ, 2013, BRIT J PHARMACOL, V170, P1064, DOI 10.1111/bph.12336
   Félétou M, 2009, BRIT J PHARMACOL, V156, P563, DOI 10.1111/j.1476-5381.2008.00060.x
   Förstermann U, 2006, CIRCULATION, V113, P1708, DOI 10.1161/CIRCULATIONAHA.105.602532
   Gluais P, 2006, AM J PHYSIOL-HEART C, V291, pH2255, DOI 10.1152/ajpheart.01115.2005
   Gokce N, 2002, CIRCULATION, V105, P1567, DOI 10.1161/01.CIR.0000012543.55874.47
   GOODYEAR LJ, 1995, J CLIN INVEST, V95, P2195, DOI 10.1172/JCI117909
   HUTCHINSON PJA, 1987, EUR J PHARMACOL, V141, P445, DOI 10.1016/0014-2999(87)90563-2
   Ijaz S, 2005, MICROVASC RES, V70, P129, DOI 10.1016/j.mvr.2005.08.001
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jiang ZY, 1999, J CLIN INVEST, V104, P447, DOI 10.1172/JCI5971
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Kujiraoka T, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23158521
   Kujiraoka T, 2013, J AM HEART ASSOC, V2, DOI 10.1161/JAHA.113.000361
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lan F, 2008, J BIOL CHEM, V283, P27628, DOI 10.1074/jbc.M805711200
   Li R, 2010, EUR J PHARMACOL, V628, P140, DOI 10.1016/j.ejphar.2009.11.038
   Lynch CM, 2013, STROKE, V44, P3195, DOI 10.1161/STROKEAHA.113.001366
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Mancia G, 2007, HYPERTENSION, V49, P40, DOI 10.1161/01.HYP.0000251933.22091.24
   Masaki N, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.118.010816
   Miller FJ, 1998, CIRC RES, V82, P1298, DOI 10.1161/01.RES.82.12.1298
   Pasarín M, 2017, WORLD J GASTROENTERO, V23, P6777, DOI 10.3748/wjg.v23.i37.6777
   Pierdomenico SD, 2007, AM J HYPERTENS, V20, P1291, DOI 10.1016/j.amjhyper.2007.06.011
   Rask-Madsen C, 2012, ARTERIOSCL THROM VAS, V32, P2052, DOI 10.1161/ATVBAHA.111.241919
   Reaven G, 2004, ENDOCRIN METAB CLIN, V33, P283, DOI 10.1016/j.ecl.2004.03.002
   Rosado E, 2013, HEPATOLOGY, V58, P1424, DOI 10.1002/hep.26520
   RUBANYI GM, 1986, AM J PHYSIOL, V250, pH822, DOI 10.1152/ajpheart.1986.250.5.H822
   Satoh Y, 2011, J NEUROSCI, V31, P11953, DOI 10.1523/JNEUROSCI.2349-11.2011
   Selzner M, 2000, HEPATOLOGY, V32, P1280, DOI 10.1053/jhep.2000.20528
   Sesti G, 2001, FASEB J, V15, P2099, DOI 10.1096/fj.01-0009rev
   SHIMOKAWA H, 1991, CIRCULATION, V83, P652, DOI 10.1161/01.CIR.83.2.652
   Sugamura K, 2011, FREE RADICAL BIO MED, V51, P978, DOI 10.1016/j.freeradbiomed.2011.05.004
   Tang YF, 2010, GENESIS, V48, P563, DOI 10.1002/dvg.20654
   Targher G, 2005, DIABETES, V54, P3541, DOI 10.2337/diabetes.54.12.3541
   VALLANCE P, 1989, LANCET, V2, P997
   Vanhoutte PM, 2017, ACTA PHYSIOL, V219, P22, DOI 10.1111/apha.12646
   Vanhoutte P M, 1995, Hypertens Res, V18, P87, DOI 10.1291/hypres.18.87
   Vial G, 2015, DIABETES, V64, P2254, DOI 10.2337/db14-1220
   Vicent D, 2003, J CLIN INVEST, V111, P1373, DOI 10.1172/JCI200315211
   Vincent MA, 2004, DIABETES, V53, P1418, DOI 10.2337/diabetes.53.6.1418
   Worth NF, 2005, ATHEROSCLEROSIS, V183, P65, DOI 10.1016/j.atherosclerosis.2005.02.034
   YANAGISAWA M, 1988, NATURE, V332, P411, DOI 10.1038/332411a0
   Yki-Järvinen H, 2014, LANCET DIABETES ENDO, V2, P901, DOI 10.1016/S2213-8587(14)70032-4
   Zhang MA, 2011, ARTERIOSCL THROM VAS, V31, P125, DOI 10.1161/ATVBAHA.110.207712
   Zou MH, 2002, J CLIN INVEST, V109, P817, DOI 10.1172/JCI200214442
   Zuccollo A, 2005, CIRCULATION, V112, P3001, DOI 10.1161/CIRCULATIONAHA.105.581892
NR 53
TC 6
Z9 6
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD DEC 6
PY 2022
VL 11
IS 23
DI 10.1161/JAHA.122.027538
PG 16
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 6T7OX
UT WOS:000893866000025
PM 36382966
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Leguina-Ruzzi, A
   Pereira, J
   Pereira-Flores, K
   Valderas, JP
   Mezzano, D
   Velarde, V
   Sáez, CG
AF Leguina-Ruzzi, Alberto
   Pereira, Jaime
   Pereira-Flores, Karla
   Valderas, Juan P.
   Mezzano, Diego
   Velarde, Victoria
   Saez, Claudia G.
TI Increased RhoA/Rho-Kinase Activity and Markers of Endothelial
   Dysfunction in Young Adult Subjects with Metabolic Syndrome
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID INSULIN-RESISTANCE; SERUM CREATININE; LINKING OBESITY; RISK-FACTOR;
   ACID; ASSOCIATION; PLASMA; ACTIVATION; ADIPOCYTE; OXIDATION
AB Background: Metabolic syndrome, a chronic condition associated with higher risk of cardiovascular diseases, is increasingly prevalent in young adults. Dyslipidemia, proinflammatory cytokines, endothelial dysfunction signs, and RhoA/Rho-kinase (ROCK) activation are considered risk factors of cardiovascular diseases. The occurrence of these factors in young patients with metabolic syndrome but without type 2 diabetes or hypertension has not been fully studied. The objective of this study was to evaluate young subjects with enlarged waist circumference and dyslipidemia but without type 2 diabetes or hypertension,for markers associated with a higher risk of cardiovascular diseases. Methods: Thirty-two male patients aged 311.3 years diagnosed with metabolic syndrome according to the National Cholesterol Education Program Adult Treatment Panel III guide for enlarged waist circumference, elevated triglycerides, and low HDL levels, but with blood pressure and fasting glucose within normal ranges, were evaluated for RhoA/ROCK activity in leukocytes, serum fatty acid methyl esters profile, proinflammatory cytokines, and oxidative stress markers in addition to thrombin generation and biochemical analysis. Age- and gender-matched healthy subjects were equivalently evaluated. Results: Patients showed higher RhoA/ROCK activity, elevated levels of interleukin-6, soluble CD40L, monocyte chemoattractant protein, and high-sensitivity C-reactive protein (P<0.001) as well as parameters of endogenous thrombin generation potential (P<0.05) compared with healthy subjects. Increased thiobarbituric acid reactive substances, advanced oxidation protein product, and insulin levels and low nitric oxide biodisponibility (P<0.001) were also found in patients as compared with controls. Palmitic acid was one of the saturated fatty acids found to be significantly elevated in patients compared with control subjects (P=0.0087). Conclusions: Increased markers of cardiovascular risk are already present in young adults with metabolic syndrome but without type 2 diabetes or hypertension.
C1 [Leguina-Ruzzi, Alberto; Pereira, Jaime; Pereira-Flores, Karla; Mezzano, Diego; Saez, Claudia G.] Pontificia Univ Catolica Chile, Sch Med, Dept Hematol & Oncol, Santiago 8330334, Chile.
   [Velarde, Victoria] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Dept Physiol, Santiago 8330334, Chile.
   [Valderas, Juan P.] Univ Antofagasta, Fac Med Odontol, Dept Ciencias Med, Antofagasta, Chile.
C3 Pontificia Universidad Catolica de Chile; Pontificia Universidad
   Catolica de Chile; Universidad de Antofagasta
RP Sáez, CG (corresponding author), Pontificia Univ Catolica Chile, Sch Med, Dept Hematol & Oncol, Portugal 61,Second Floor, Santiago 8330334, Chile.
EM cgsaez@med.puc.cl
RI ; Leguina-Ruzzi, Alberto/K-5805-2017; Saez Steeger,
   Claudia/HCI-4472-2022
OI Velarde, Victoria/0000-0002-4465-831X; Leguina-Ruzzi,
   Alberto/0000-0002-4761-3491; , Pereira-Flores K/0009-0000-1357-5231;
   Saez Steeger, Claudia/0000-0001-7183-1491
FU Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT)
   [1141051]; Puente [20/2013]; Direccion de Investigacion y Doctorado
   (DIDEMUC); Faculty of Medicine: Doctoral Thesis Support; Comision
   Nacional de Investigacio n Cientifica y Tecnologica (CONICYT)
FX This work was supported by Fondo Nacional de Desarrollo Cientifico y
   Tecnologico (FONDECYT) grant no. 1141051 (J. Pereira), Puente 20/2013
   (V. Velarde), a Comision Nacional de Investigacio n Cientifica y
   Tecnologica (CONICYT) doctoral grant (A. Leguina-Ruzzi), and the
   Direccion de Investigacion y Doctorado (DIDEMUC), Faculty of Medicine:
   Doctoral Thesis Support (A. Leguina-Ruzzi, mentored by C.G. Saez)
CR Ait-Oufella H, 2011, ARTERIOSCL THROM VAS, V31, P969, DOI 10.1161/ATVBAHA.110.207415
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   ALBERTI SG, 2005, IDF CONS WORLDW DEF
   [Anonymous], 2006, The IDF Consensus Worldwide Definition of the Metabolic Syndrome
   Bentley-Lewis R, 2007, NAT CLIN PRACT ENDOC, V3, P696, DOI 10.1038/ncpendmet0616
   Bors W, 1987, Free Radic Res Commun, V2, P289, DOI 10.3109/10715768709065294
   Caimi G, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/824756
   Campello E, 2015, THROMB HAEMOSTASIS, V113, P85, DOI 10.1160/TH14-02-0156
   Davignon J, 2004, CIRCULATION, V109, P27, DOI 10.1161/01.CIR.0000131515.03336.f8
   Gabrielli L, 2014, AM J HYPERTENS, V27, P838, DOI 10.1093/ajh/hpt234
   Gonçalves FM, 2009, CLIN CHIM ACTA, V403, P173, DOI 10.1016/j.cca.2009.02.013
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Grundy SM, 2005, CIRCULATION, V112, pE285, DOI 10.1161/CIRCULATIONAHA.105.169405
   Guilherme A, 2008, NAT REV MOL CELL BIO, V9, P367, DOI 10.1038/nrm2391
   Harita N, 2009, DIABETES CARE, V32, P424, DOI 10.2337/dc08-1265
   Higashi Y, 2009, CIRC J, V73, P411, DOI 10.1253/circj.CJ-08-1102
   Hjelmesæth J, 2010, BMC ENDOCR DISORD, V10, DOI 10.1186/1472-6823-10-6
   Hollenberd NK, 2010, CURR HYPERTENS REP, V4, P2010
   Hopps E, 2012, EUR J INTERN MED, V23, P99, DOI 10.1016/j.ejim.2011.09.012
   Hung J, 2005, ARTERIOSCL THROM VAS, V25, P1268, DOI 10.1161/01.ATV.0000163843.70369.12
   Kien CL, 2005, AM J CLIN NUTR, V82, P320, DOI 10.1093/ajcn/82.2.320
   Kim OY, 2013, NUTR METAB CARDIOVAS, V23, P366, DOI 10.1016/j.numecd.2011.06.006
   Kong XC, 2014, ENDOCRINOLOGY, V155, P4676, DOI 10.1210/en.2014-1314
   Liu PY, 2007, J AM COLL CARDIOL, V49, P1619, DOI 10.1016/j.jacc.2006.12.043
   Loirand G, 2006, CIRC RES, V98, P322, DOI 10.1161/01.RES.0000201960.04223.3c
   Maloney E, 2009, ARTERIOSCL THROM VAS, V29, P1370, DOI 10.1161/ATVBAHA.109.188813
   Marsche G, 2009, CIRC RES, V104, P750, DOI 10.1161/CIRCRESAHA.108.193169
   Mattsson N, 2008, ANN MED, V40, P542, DOI 10.1080/07853890802307709
   Miksztowicz V, 2008, METABOLISM, V57, P1493, DOI 10.1016/j.metabol.2008.06.001
   Morange PE, 2013, THROMB HAEMOSTASIS, V110, P669, DOI 10.1160/TH13-01-0075
   Mujica V, 2008, NUTR J, V7, DOI 10.1186/1475-2891-7-14
   Nishimura Satoshi, 2009, Discov Med, V8, P55
   Pan ZX, 2011, MOL CELL BIOCHEM, V350, P39, DOI 10.1007/s11010-010-0680-6
   Petrie JL, 2013, AM J PHYSIOL-ENDOC M, V305, pE1255, DOI 10.1152/ajpendo.00214.2013
   Poon VTW, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0111647
   Quiroga T, 2003, PATHOPHYSIOL HAEMO T, V33, P30, DOI 10.1159/000071639
   Reynoso R, 2003, MOL CELL BIOCHEM, V246, P155, DOI 10.1023/A:1023423005187
   Rogowski O, 2010, J INFLAMM-LOND, V7, DOI 10.1186/1476-9255-7-35
   Ruf W, 2015, HAMOSTASEOLOGIE, V35, P279, DOI 10.5482/HAMO-14-11-0068
   Schinzari F, 2012, AM J PHYSIOL-ENDOC M, V303, pE806, DOI 10.1152/ajpendo.00206.2012
   Stein PD, 2005, AM J MED, V118, P978, DOI 10.1016/j.amjmed.2005.03.012
   Syamala S, 2007, J HYPERTENS, V25, P1583, DOI 10.1097/HJH.0b013e32813aeb6c
   Szmitko PE, 2003, CIRCULATION, V108, P1917, DOI 10.1161/01.CIR.0000089190.95415.9F
   THODE J, 1989, J LIPID RES, V30, P1299
   Tziakas DN, 2005, ANN VASC SURG, V19, P529, DOI 10.1007/s10016-005-5018-6
   Vayá A, 2011, METAB SYNDR RELAT D, V9, P197, DOI 10.1089/met.2010.0117
   Weber MA, 2014, J CLIN HYPERTENS, V16, P14, DOI 10.1111/jch.12237
   Wiberg B, 2006, STROKE, V37, P2898, DOI 10.1161/01.STR.0000249056.24657.8b
   Yao L, 2010, J CARDIOVASC DIS RES, V4, P165
NR 50
TC 21
Z9 22
U1 0
U2 9
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD NOV 1
PY 2015
VL 13
IS 9
BP 373
EP 380
DI 10.1089/met.2015.0061
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CU9TP
UT WOS:000363888500002
PM 26512756
DA 2025-06-11
ER

PT J
AU Robertson, K
   Griffith, TA
   Helman, TJ
   Hatton-Jones, K
   Naghipour, S
   Robertson, DA
   Peart, JN
   Headrick, JP
   Du Toit, EF
AF Robertson, Kai
   Griffith, Tia A.
   Helman, Tessa J.
   Hatton-Jones, Kyle
   Naghipour, Saba
   Robertson, Dylan A.
   Peart, Jason N.
   Headrick, John P.
   Du Toit, Eugene F.
TI Early life stress exacerbates the obesogenic and anxiogenic effects of a
   Western diet without worsening cardiac ischaemic tolerance in male mice
SO JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
LA English
DT Article
DE Anxiogenesis; early life stress; Western diet; cardiometabolic risk;
   dietary obesity; myocardial ischaemia-reperfusion
ID NATIONAL COMORBIDITY SURVEY; LEFT-VENTRICULAR MASS; MATERNAL SEPARATION;
   INSULIN-RESISTANCE; CHILDHOOD ABUSE; DEVELOPMENTAL ORIGINS;
   MYOCARDIAL-ISCHEMIA; HEART-DISEASE; RODENT MODEL; FEMALE RATS
AB Early life stress (ELS) and a Western diet (WD) promote mood and cardiovascular disorders, however, how these risks interact in disease pathogenesis is unclear. We assessed effects of ELS with or without a subsequent WD on behaviour, cardiometabolic risk factors, and cardiac function/ischaemic tolerance in male mice. Fifty-six new-born male C57BL/6J mice were randomly allocated to a control group (CON) undisturbed before weaning, or to maternal separation (3h/day) and early (postnatal day 17) weaning (MSEW). Mice consumed standard rodent chow (CON, n = 14; MSEW, n = 15) or WD chow (WD, n = 19; MSEW + WD, n = 19) from week 8 to 24. Fasted blood was sampled and open field test and elevated plus maze (EPM) tests undertaken at 7, 15, and 23 weeks of age, with hearts excised at 24 weeks for Langendorff perfusion (evaluating pre- and post-ischaemic function). MSEW alone transiently increased open field activity at 7 weeks; body weight and serum triglycerides at 4 and 7 weeks, respectively; and final blood glucose levels and insulin resistance at 23 weeks. WD increased insulin resistance and body weight gain, the latter potentiated by MSEW. MSEW + WD was anxiogenic, reducing EPM open arm activity vs. WD alone. Although MSEW had modest metabolic effects and did not influence cardiac function or ischaemic tolerance in lean mice, it exacerbated weight gain and anxiogenesis, and improved ischaemic tolerance in WD fed animals. MSEW-induced increases in body weight (obesity) in WD fed animals in the absence of changes in insulin resistance may have protected the hearts of these mice.
C1 [Robertson, Kai; Griffith, Tia A.; Helman, Tessa J.; Hatton-Jones, Kyle; Naghipour, Saba; Robertson, Dylan A.; Peart, Jason N.; Headrick, John P.; Du Toit, Eugene F.] Griffith Univ Gold Coast, Sch Pharm & Med Sci, Southport, Qld, Australia.
C3 Griffith University; Griffith University - Gold Coast Campus
RP Du Toit, EF (corresponding author), Griffith Univ Gold Coast, Sch Pharm & Med Sci, Southport, Qld, Australia.
EM j.dutoit@griffith.edu.au
RI Helman, Tessa/IWM-3236-2023; Naghipour, Saba/NKO-8765-2025
OI Hatton-Jones, Kyle/0000-0003-3988-0829; Naghipour,
   Saba/0000-0001-6624-5674; Robertson, Kai/0009-0005-5477-951X; Helman,
   Tessa/0000-0001-8788-3683
FU Griffith University
FX The work was supported by a seed grant and HDR student funds from
   Griffith University.
CR Afifi TO, 2006, CHILD ABUSE NEGLECT, V30, P1093, DOI 10.1016/j.chiabu.2006.04.006
   ALPERT MA, 1995, AM J CARDIOL, V76, P1194, DOI 10.1016/S0002-9149(99)80338-5
   [Anonymous], 2020, Child maltreatment 2018
   Arima Y, 2020, J CARDIOL, V76, P14, DOI 10.1016/j.jjcc.2020.02.003
   Carlyle BC, 2012, DEV PSYCHOPATHOL, V24, P1401, DOI 10.1017/S095457941200079X
   Carroll JE, 2013, P NATL ACAD SCI USA, V110, P17149, DOI 10.1073/pnas.1315458110
   Cartwright-Hatton S, 2006, CLIN PSYCHOL REV, V26, P817, DOI 10.1016/j.cpr.2005.12.002
   Cottone P, 2009, P NATL ACAD SCI USA, V106, P20016, DOI 10.1073/pnas.0908789106
   Dandi E, 2018, INT J DEV NEUROSCI, V67, P19, DOI 10.1016/j.ijdevneu.2018.03.003
   Danielsson A, 2009, MOL MED, V15, P228, DOI 10.2119/molmed.2009.00037
   Rodrigues MED, 2017, BRAIN BEHAV IMMUN, V59, P158, DOI 10.1016/j.bbi.2016.08.021
   de Souza JA, 2018, APPETITE, V123, P114, DOI 10.1016/j.appet.2017.12.004
   Desmet PMA, 2008, APPETITE, V50, P290, DOI 10.1016/j.appet.2007.08.003
   Dinel AL, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024325
   Dixon JB, 2003, ARCH INTERN MED, V163, P2058, DOI 10.1001/archinte.163.17.2058
   Dong MX, 2004, CIRCULATION, V110, P1761, DOI 10.1161/01.CIR.0000143074.54995.7F
   Donner D, 2013, DIS MODEL MECH, V6, P457, DOI 10.1242/dmm.010959
   Donner DG, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0138019
   du Toit EF, 2008, AM J PHYSIOL-HEART C, V294, pH2336, DOI 10.1152/ajpheart.00481.2007
   Du Toit EF, 2020, AM J PHYSIOL-REG I, V319, pR347, DOI 10.1152/ajpregu.00322.2019
   Egan AE, 2019, HORM BEHAV, V115, DOI 10.1016/j.yhbeh.2019.07.005
   Eriksson M, 2014, AM J HUM BIOL, V26, P111, DOI 10.1002/ajhb.22502
   Faith MS, 2004, CURR OPIN PSYCHIATR, V17, P9, DOI 10.1097/00001504-200401000-00003
   FAMULARO R, 1992, J AM ACAD CHILD PSY, V31, P863, DOI 10.1097/00004583-199209000-00013
   George ED, 2010, BMC NEUROSCI, V11, DOI 10.1186/1471-2202-11-123
   Green JG, 2010, ARCH GEN PSYCHIAT, V67, P113, DOI 10.1001/archgenpsychiatry.2009.186
   Hales CN, 2001, BRIT MED BULL, V60, P5, DOI 10.1093/bmb/60.1.5
   Hatton-Jones K, 2022, PHYSIOL REP, V10, DOI 10.14814/phy2.15170
   Hatton-Jones KM, 2022, NEUROGASTROENT MOTIL, V34, DOI 10.1111/nmo.14300
   Heim C, 2001, BIOL PSYCHIAT, V49, P1023, DOI 10.1016/S0006-3223(01)01157-X
   Hemmingsson E, 2018, CURR OBES REP, V7, P204, DOI 10.1007/s13679-018-0310-2
   Ho DH, 2016, AM J PHYSIOL-HEART C, V310, pH1267, DOI 10.1152/ajpheart.00016.2016
   Hovens JGFM, 2012, ACTA PSYCHIAT SCAND, V126, P198, DOI 10.1111/j.1600-0447.2011.01828.x
   Iacobellis G, 2004, J AM COLL CARDIOL, V44, P2257, DOI 10.1016/j.jacc.2004.09.012
   Iacobellis G, 2002, OBES RES, V10, P767, DOI 10.1038/oby.2002.104
   Ijeaku IGS., 2021, J Psychiatry Mental Health, V6, P4
   Ilchmann-Diounou H, 2019, BRAIN BEHAV IMMUN, V80, P452, DOI 10.1016/j.bbi.2019.04.025
   Iwasaki S, 2000, PHYSIOL BEHAV, V70, P551, DOI 10.1016/S0031-9384(00)00305-X
   Jedd K, 2015, DEV PSYCHOPATHOL, V27, P1577, DOI 10.1017/S0954579415000954
   Kaufman D, 2007, DIABETES, V56, P1382, DOI 10.2337/db06-1409
   Ke XR, 2020, PHYSIOL REP, V8, DOI 10.14814/phy2.14407
   Kessler RC, 2003, J AFFECT DISORDERS, V74, P5, DOI 10.1016/S0165-0327(02)00426-3
   KESSLER RC, 1993, J AFFECT DISORDERS, V29, P85, DOI 10.1016/0165-0327(93)90026-G
   Krishna S, 2016, PHYSIOL BEHAV, V157, P196, DOI 10.1016/j.physbeh.2016.02.007
   Lehmann J, 2000, REV NEUROSCIENCE, V11, P383
   Loria AS, 2014, ACTA PHYSIOL, V210, P277, DOI 10.1111/apha.12189
   Lukkes JL, 2009, HORM BEHAV, V55, P248, DOI 10.1016/j.yhbeh.2008.10.014
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Machado TD, 2013, STRESS, V16, P549, DOI 10.3109/10253890.2013.816841
   Maggio CA, 2003, ENDOCRIN METAB CLIN, V32, P805, DOI 10.1016/S0889-8529(03)00071-9
   Maniam J, 2010, PSYCHONEUROENDOCRINO, V35, P717, DOI 10.1016/j.psyneuen.2009.10.013
   McCauley J, 1997, JAMA-J AM MED ASSOC, V277, P1362, DOI 10.1001/jama.277.17.1362
   Medford HM, 2014, AM J PHYSIOL-REG I, V306, pR519, DOI 10.1152/ajpregu.00253.2013
   Miller AL, 2018, ACAD PEDIATR, V18, P685, DOI 10.1016/j.acap.2018.01.007
   Millstein RA, 2007, NEUROSCI BIOBEHAV R, V31, P3, DOI 10.1016/j.neubiorev.2006.05.003
   Mizunoya W, 2013, SPRINGERPLUS, V2, DOI 10.1186/2193-1801-2-165
   Murphy MO, 2017, NEUROSCI BIOBEHAV R, V74, P453, DOI 10.1016/j.neubiorev.2016.07.018
   Murphy MO, 2017, AM J PHYSIOL-ENDOC M, V312, pE98, DOI 10.1152/ajpendo.00308.2016
   Murthy S, 2018, FRONT BEHAV NEUROSCI, V12, DOI 10.3389/fnbeh.2018.00157
   Nakajima S, 2020, INT J OBESITY, V44, P727, DOI 10.1038/s41366-019-0468-z
   Nemeroff CB, 2016, NEURON, V89, P892, DOI 10.1016/j.neuron.2016.01.019
   Ng M, 2014, LANCET, V384, P746
   Ogden CL, 2014, JAMA-J AM MED ASSOC, V311, P806, DOI 10.1001/jama.2014.732
   Ogrodnik M, 2019, CELL METAB, V29, P1061, DOI [10.1016/j.cmet.2018.12.008, 10.1016/j.cmet.2019.01.013]
   Oi M, 2018, EUR J PHARMACOL, V826, P148, DOI 10.1016/j.ejphar.2018.02.050
   Organization WH, 2009, Cardiovascular diseases (cvds)
   Osadchiy V, 2019, OBES SCI PRACT, V5, P416, DOI 10.1002/osp4.362
   Parry SA, 2017, NUTRIENTS, V9, DOI 10.3390/nu9080818
   Paternain L, 2012, DIS MODEL MECH, V5, P691, DOI 10.1242/dmm.009043
   Peterson LR, 2004, J AM COLL CARDIOL, V43, P1399, DOI 10.1016/j.jacc.2003.10.062
   Purcell RH, 2011, PHYSIOL BEHAV, V104, P474, DOI 10.1016/j.physbeh.2011.05.012
   Pynoos RS, 1999, BIOL PSYCHIAT, V46, P1542, DOI 10.1016/S0006-3223(99)00262-0
   Raff H, 2018, AM J PHYSIOL-REG I, V314, pR12, DOI 10.1152/ajpregu.00271.2017
   Reichelt ME, 2009, EXP PHYSIOL, V94, P54, DOI 10.1113/expphysiol.2008.043554
   Rorabaugh BR, 2015, STRESS, V18, P645, DOI 10.3109/10253890.2015.1087505
   Ruiz AL, 2020, HEALTH PSYCHOL, V39, P986, DOI 10.1037/hea0001027
   Russell JS, 2019, EXP PHYSIOL, V104, P1868, DOI 10.1113/EP088024
   Scheuer DA, 1998, AM J PHYSIOL-REG I, V274, pR470, DOI 10.1152/ajpregu.1998.274.2.R470
   Seibenhener ML, 2015, JOVE-J VIS EXP, DOI 10.3791/52434
   Shackman JE, 2007, EMOTION, V7, P838, DOI 10.1037/1528-3542.7.4.838
   Sial OK, 2021, FRONT NEUROSCI-SWITZ, V15, DOI 10.3389/fnins.2021.701919
   Sowers JR, 2003, AM J MED, V115, P37, DOI 10.1016/j.amjmed.2003.08.012
   Stapelberg NJ, 2012, AUST NZ J PSYCHIAT, V46, P946, DOI 10.1177/0004867412444624
   Syed Shariful A, 2017, Chronic Stress (Thousand Oaks), V1, DOI 10.1177/2470547017694461
   Thomas C, 2008, PEDIATRICS, V121, pE1240, DOI 10.1542/peds.2007-2403
   Thorpe JB, 2014, HORM METAB RES, V46, P211, DOI 10.1055/s-0033-1363958
   Vaccarino V, 2014, PSYCHOSOM MED, V76, P171, DOI 10.1097/PSY.0000000000000045
   Van Leuven S, 2020, CURR DEV NUTR, V4, P1239, DOI DOI 10.1093/CDN/NZAA057_055
   Vos T, 2020, LANCET, V396, P1562
   Walf AA, 2007, NAT PROTOC, V2, P322, DOI 10.1038/nprot.2007.44
   Wang D, 2020, TRANSL PSYCHIAT, V10, DOI 10.1038/s41398-020-0856-0
   Wensley I, 2013, EXP PHYSIOL, V98, P1552, DOI 10.1113/expphysiol.2013.074948
   Whooley MA, 2013, ANNU REV CLIN PSYCHO, V9, P327, DOI 10.1146/annurev-clinpsy-050212-185526
   Wiss DA, 2020, PHYSIOL BEHAV, V223, DOI 10.1016/j.physbeh.2020.112964
   Wondmkun YT, 2020, DIABET METAB SYND OB, V13, P3611, DOI 10.2147/DMSO.S275898
   Wong CY, 2004, CIRCULATION, V110, P3081, DOI 10.1161/01.CIR.0000147184.13872.0F
   Yusuf S, 2005, LANCET, V366, P1640, DOI 10.1016/S0140-6736(05)67663-5
   Zheng Y, 2017, JAMA-J AM MED ASSOC, V318, P255, DOI 10.1001/jama.2017.7092
NR 98
TC 1
Z9 1
U1 2
U2 2
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2040-1744
EI 2040-1752
J9 J DEV ORIG HLTH DIS
JI J. Dev. Orig. Health Dis.
PD SEP 18
PY 2024
VL 15
AR e14
DI 10.1017/S2040174424000205
PG 13
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA G1X7M
UT WOS:001314645400001
PM 39291337
DA 2025-06-11
ER

PT J
AU Flory, JD
   Bierer, LM
   Yehuda, R
AF Flory, Janine D.
   Bierer, Linda M.
   Yehuda, Rachel
TI Maternal exposure to the holocaust and health complaints in offspring
SO DISEASE MARKERS
LA English
DT Article
ID POSTTRAUMATIC-STRESS-DISORDER; CORONARY-HEART-DISEASE; DEVELOPMENTAL
   ORIGINS; BLOOD-PRESSURE; METABOLIC SYNDROME; LOW CORTISOL; ADULT LIFE;
   RISK; PTSD; MORTALITY
AB Although the link between chronic stress and the development of cardiovascular and metabolic diseases of adulthood has been known for some time, there is growing recognition that early environmental influences may result in developmental programming via epigenetic mechanisms, thereby affecting the developmental trajectory of disease progression. Previous studies support the idea that offspring of Holocaust survivors may have been subjected to early developmental programming. We evaluated the relationship between parental exposure to the Holocaust and self-reported health ratings and disorders made by their adult offspring (i.e., second generation Holocaust survivors). A total of 137 subjects were evaluated. Regression analyses demonstrated that maternal but not paternal exposure to the Holocaust was related to poorer subjective impressions of emotional and physical health. This relationship was diminished when the offspring's own level of trait anxiety was considered. Offspring with maternal, but not paternal, Holocaust exposure also reported greater use of psychotropic and other medications, including medications for the treatment of hypertension and lipid disorders. The mechanism linking these health outcomes and maternal exposure deserves further investigation, including the possibility that fetal or early developmental programming is involved.
C1 [Flory, Janine D.] CUNY, Queens Coll, Dept Psychol, Flushing, NY 11367 USA.
   [Flory, Janine D.] CUNY, Grad Ctr, Flushing, NY 11367 USA.
   [Flory, Janine D.; Bierer, Linda M.; Yehuda, Rachel] Bronx Vet Affairs Med Ctr, Dept Psychiat, Bronx, NY USA.
   [Yehuda, Rachel] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA.
C3 City University of New York (CUNY) System; Queens College NY (CUNY);
   City University of New York (CUNY) System; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); James J. Peters VA
   Medical Center; Icahn School of Medicine at Mount Sinai
RP Flory, JD (corresponding author), CUNY, Queens Coll, Dept Psychol, NSB E-318,65-30 Kissena Blvd, Flushing, NY 11367 USA.
EM janine.flory@qc.cuny.edu
FU NIMH [R01-MH-64675-01]
FX This work was supported by NIMH grant R01-MH-64675-01 ("Biology of Risk
   and PTSD in Holocaust Survivor Offspring") to Rachel Yehuda.
CR Almeida ND, 2010, PSYCHOSOM MED, V72, P148, DOI 10.1097/PSY.0b013e3181c925cb
   [Anonymous], 1998, Manual for the Childhood Trauma Questionnaire
   Barker DJP, 2007, J INTERN MED, V261, P412, DOI 10.1111/j.1365-2796.2007.01809.x
   BARKER DJP, 1989, BMJ-BRIT MED J, V298, P564, DOI 10.1136/bmj.298.6673.564
   BARKER DJP, 1988, BRIT MED J, V297, P134, DOI 10.1136/bmj.297.6641.134-b
   Barker DJP, 2001, BMJ-BRIT MED J, V323, P1273, DOI 10.1136/bmj.323.7324.1273
   BARKER DJP, 1995, BRIT MED J, V311, P1203, DOI 10.1136/bmj.311.7014.1203
   BARKER DJP, 1990, BMJ-BRIT MED J, V301, P259, DOI 10.1136/bmj.301.6746.259
   Boscarino JA, 2008, PSYCHOSOM MED, V70, P668, DOI 10.1097/PSY.0b013e31817bccaf
   Buchmann AF, 2010, PSYCHOSOM MED, V72, P156, DOI 10.1097/PSY.0b013e3181c88343
   COSTA PT, 1987, J PERS, V55, P299, DOI 10.1111/j.1467-6494.1987.tb00438.x
   De Boo HA, 2006, AUST NZ J OBSTET GYN, V46, P4, DOI 10.1111/j.1479-828X.2006.00506.x
   Dong MX, 2004, CIRCULATION, V110, P1761, DOI 10.1161/01.CIR.0000143074.54995.7F
   EDWARDS CRW, 1993, LANCET, V341, P355, DOI 10.1016/0140-6736(93)90148-A
   Gluckman PD, 2009, NAT REV ENDOCRINOL, V5, P401, DOI 10.1038/nrendo.2009.102
   Heppner PS, 2009, BMC MED, V7, DOI 10.1186/1741-7015-7-1
   Kang HK, 2006, ANN EPIDEMIOL, V16, P381, DOI 10.1016/j.annepidem.2005.03.004
   Kinzie JD, 2008, J NERV MENT DIS, V196, P108, DOI 10.1097/NMD.0b013e318162aa51
   Koupil I, 2008, INT J OBESITY, V32, P73, DOI 10.1038/sj.ijo.0803681
   Koupil I, 2007, EUR J EPIDEMIOL, V22, P223, DOI 10.1007/s10654-007-9113-6
   Kubzansky LD, 2007, ARCH GEN PSYCHIAT, V64, P109, DOI 10.1001/archpsyc.64.1.109
   Kubzansky LD, 2009, HEALTH PSYCHOL, V28, P125, DOI 10.1037/0278-6133.28.1.125
   Lahey BB, 2009, AM PSYCHOL, V64, P241, DOI 10.1037/a0015309
   Lauterbach D, 1997, J TRAUMA STRESS, V10, P499, DOI 10.1002/jts.2490100313
   Levitt NS, 1996, NEUROENDOCRINOLOGY, V64, P412, DOI 10.1159/000127146
   McMillen IC, 2005, PHYSIOL REV, V85, P571, DOI 10.1152/physrev.00053.2003
   Räikkönen K, 2009, SCAND J PSYCHOL, V50, P583, DOI 10.1111/j.1467-9450.2009.00786.x
   Reik W, 2001, NAT REV GENET, V2, P21, DOI 10.1038/35047554
   Scherrer JF, 2010, AM HEART J, V159, P772, DOI 10.1016/j.ahj.2010.02.033
   Seckl JR, 2007, NAT CLIN PRACT ENDOC, V3, P479, DOI 10.1038/ncpendmet0515
   Seckl JR, 2006, ANN NY ACAD SCI, V1071, P351, DOI 10.1196/annals.1364.027
   Seckl JR, 2007, PROG BRAIN RES, V167, P17, DOI 10.1016/S0079-6123(07)67002-2
   Seckl JR, 1999, BIOCHEM SOC T, V27, P74, DOI 10.1042/bst0270074
   Shoener JA, 2006, AM J PHYSIOL-REG I, V290, pR1366, DOI 10.1152/ajpregu.00757.2004
   Shonkoff JP, 2009, JAMA-J AM MED ASSOC, V301, P2252, DOI 10.1001/jama.2009.754
   Spielberger C. D., 1970, MANUAL STATE TRAIT A
   Violanti John M, 2006, Int J Emerg Ment Health, V8, P227
   Weiss A, 2005, PSYCHOSOM MED, V67, P724, DOI 10.1097/01.psy.0000181272.58103.18
   Welberg LAM, 2000, EUR J NEUROSCI, V12, P1047, DOI 10.1046/j.1460-9568.2000.00958.x
   Wilkinson LS, 2007, NAT REV NEUROSCI, V8, P832, DOI 10.1038/nrn2235
   Yehuda R, 2000, AM J PSYCHIAT, V157, P1252, DOI 10.1176/appi.ajp.157.8.1252
   Yehuda R, 2002, PSYCHONEUROENDOCRINO, V27, P171, DOI 10.1016/S0306-4530(01)00043-9
   YEHUDA R, PSYCHOPHARM IN PRESS
   Yehuda R, 2007, ARCH GEN PSYCHIAT, V64, P1040, DOI 10.1001/archpsyc.64.9.1040
   Yehuda R, 2007, AM J PSYCHIAT, V164, P163, DOI 10.1176/appi.ajp.164.1.163
   Yehuda R, 2007, PROG BRAIN RES, V167, P121, DOI 10.1016/S0079-6123(07)67009-5
   Yehuda R, 2009, J PSYCHIATR RES, V43, P877, DOI 10.1016/j.jpsychires.2008.12.003
NR 47
TC 50
Z9 58
U1 1
U2 20
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0278-0240
EI 1875-8630
J9 DIS MARKERS
JI Dis. Markers
PY 2011
VL 30
IS 2-3
BP 133
EP 139
DI 10.1155/2011/250470
PG 7
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine,
   Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research &
   Experimental Medicine; Pathology
GA 773YN
UT WOS:000291348100008
PM 21508517
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Fathi, M
   Alavinejad, P
   Haidari, Z
   Amani, R
AF Fathi, Mojdeh
   Alavinejad, Pezhman
   Haidari, Zahra
   Amani, Reza
TI The effects of zinc supplementation on metabolic profile and oxidative
   stress in overweight/obese patients with non-alcoholic fatty liver
   disease: A randomized, double-blind, placebo-controlled trial
SO JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
LA English
DT Article
DE Zinc supplementation; Calorie- restriction diet; Non-alcoholic fatty
   liver; Insulin resistance; Oxidative stress
ID INSULIN-RESISTANCE; NONDIABETIC PATIENTS; GLYCEMIC CONTROL; LIPID
   PROFILES; OBESE; DEFICIENCY; STEATOHEPATITIS; PATHOGENESIS; HOMEOSTASIS;
   ADAPTATION
AB Background: Evidence indicates the positive effects of zinc on insulin resistance and oxidative stress in metabolic syndrome or diabetes. Non-alcoholic fatty liver disease (NAFLD) is the main hepatic manifestation of insulin resistance and metabolic syndrome. The present study is the first clinical trial that evaluated the effects of zinc supplementation on metabolic and oxidative stress status in overweight/obese patients with NAFLD undergoing calorie- restriction diet. Methods: Fifty six overweight/obese patients with confirmed mild to moderate NAFLD using ultrasonography were randomly allocated to receive 30 mg elemental zinc supplement (n = 29) or placebo (n = 27) along with weight loss diet for 12 weeks. Serum levels of zinc, homeostasis model of assessment-estimated insulin resistance (HOMA-IR), lipid profile, serum superoxide dismutasl (SOD1) and malondialdhyde (MDA) levels were assessed.
   Results: Serum levels of insulin, SOD1, MDA and HOMA-IR were improved in the treatment group (p < 0.05). Within group comparison showed significant reduction in serum FBS, HbA(1C), TC, LDL-c and TG in the treatment group. Conclusion: Zinc supplementation for three months improved insulin resistance and oxidative stress status in overweight/obese NAFLD patients with no beneficial effects on lipid profiles over weight loss diet.
C1 [Fathi, Mojdeh; Amani, Reza] Isfahan Univ Med Sci, Food Secur Res Ctr, Sch Nutr & Food Sci, Dept Clin Nutr, Esfahan 8173948763, Iran.
   [Alavinejad, Pezhman] Ahvaz Jundishapur Univ Med Sci, Ahvaz Imam Hosp, Alimentary Tract Res Ctr, Ahvaz, Iran.
   [Haidari, Zahra] Isfahan Univ Med Sci, Sch Hlth, Dept Biostat & Epidemiol, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Ahvaz Jundishapur University of
   Medical Sciences (AJUMS); Isfahan University of Medical Sciences
RP Amani, R (corresponding author), Isfahan Univ Med Sci, Food Secur Res Ctr, Sch Nutr & Food Sci, Dept Clin Nutr, Esfahan 8173948763, Iran.
EM r_amani@mail.mui.ac.ir
RI Alavinejad, Pezhman/AAD-2742-2020; Amani, Reza/U-7483-2017
FU Iran National Science Foundation (INSF) [97014520]
FX The study was funded by a research grant from Iran National Science
   Foundation (INSF) (Grant Number: 97014520).
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Antonyuk SV, 2009, J MOL BIOL, V388, P310, DOI 10.1016/j.jmb.2009.03.026
   Asghari S, 2019, J TRACE ELEM MED BIO, V55, P20, DOI 10.1016/j.jtemb.2019.05.007
   Ashtary-Larky D, 2017, INT J ENDOCRINOL MET, V15, DOI 10.5812/ijem.13249
   Bender DV, 2017, ACTA CLIN CROAT, V56, P625, DOI 10.20471/acc.2017.56.04.07
   Bjorklund G, 2020, CURR MED CHEM, V27, P6643, DOI 10.2174/0929867326666190902122155
   Buzzetti E, 2016, METABOLISM, V65, P1038, DOI 10.1016/j.metabol.2015.12.012
   Byrne CD, 2015, J HEPATOL, V62, pS47, DOI 10.1016/j.jhep.2014.12.012
   Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI 10.1002/hep.29367
   Chavez-Tapia NC, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-74
   Coudriet GM, 2017, ANTIOXIDANTS-BASEL, V6, DOI 10.3390/antiox6040085
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   Ribeiro SMD, 2016, BIOL TRACE ELEM RES, V169, P8, DOI 10.1007/s12011-015-0396-2
   Farrell GC, 2006, HEPATOLOGY, V43, pS99, DOI 10.1002/hep.20973
   Fathi M, 2020, BIOL TRACE ELEM RES, V197, P394, DOI 10.1007/s12011-019-02015-8
   Hashemipour M, 2009, HORM-INT J ENDOCRINO, V8, P279, DOI 10.14310/horm.2002.1244
   Himoto T, 2018, NUTRIENTS, V10, DOI 10.3390/nu10010088
   Himoto T, 2010, EXP THER MED, V1, P707, DOI 10.3892/etm_00000109
   Kawada N, 2007, J GASTROEN HEPATOL, V22, pS85, DOI 10.1111/j.1440-1746.2006.04661.x
   Kawano Y, 2013, J GASTROENTEROL, V48, P434, DOI 10.1007/s00535-013-0758-5
   Kelishadi R, 2010, METAB SYNDR RELAT D, V8, P505, DOI 10.1089/met.2010.0020
   Khan Mohd Idreesh, 2013, J Nat Sci Biol Med, V4, P336, DOI 10.4103/0976-9668.117002
   Kim J, 2012, NUTR RES PRACT, V6, P221, DOI 10.4162/nrp.2012.6.3.221
   Kim MH, 2017, P NATL ACAD SCI USA, V114, pE5805, DOI 10.1073/pnas.1704012114
   Kim SH, 2005, RADIOLOGY, V234, P793, DOI 10.1148/radiol.2343040142
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Kosari Farid, 2019, Iran J Pathol, V14, P17, DOI 10.30699/IJP.14.1.17
   Kurahashi T, 2015, BIOCHEM BIOPH RES CO, V467, P866, DOI 10.1016/j.bbrc.2015.10.052
   Lambert JE, 2014, GASTROENTEROLOGY, V146, P726, DOI 10.1053/j.gastro.2013.11.049
   Lucero D, 2011, CLIN CHIM ACTA, V412, P587, DOI 10.1016/j.cca.2010.12.012
   Marnett LJ, 1999, MUTAT RES-FUND MOL M, V424, P83, DOI 10.1016/S0027-5107(99)00010-X
   Marreiro DD, 2006, BIOL TRACE ELEM RES, V112, P109, DOI 10.1385/BTER:112:2:109
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McCullough A., 2005, Fatty liver disease: NASH and related disorders, P23
   Méndez-Sánchez N, 2007, LIVER INT, V27, P423, DOI 10.1111/j.1478-3231.2007.01483.x
   Nazem MR, 2019, CLIN BIOCHEM, V69, P15, DOI 10.1016/j.clinbiochem.2019.05.008
   Negrut N.M., 2013, JURNALUL PEDIATRULUI, V16
   Ortiz-Lopez C, 2012, DIABETES CARE, V35, P873, DOI 10.2337/dc11-1849
   Payahoo L, 2013, ADV PHARM BULL, V3, P161, DOI 10.5681/apb.2013.027
   Perez A, 2018, J TRACE ELEM MED BIO, V50, P560, DOI 10.1016/j.jtemb.2018.03.019
   Plauth M, 2019, CLIN NUTR, V38, P485, DOI 10.1016/j.clnu.2018.12.022
   PRASAD AS, 1983, CLIN GASTROENTEROL, V12, P713
   Qi X, 2019, ANIMALS-BASEL, V9, DOI 10.3390/ani9110898
   Ranasinghe P, 2015, DARU, V23, DOI 10.1186/s40199-015-0127-4
   Sakurai H, 2005, BIOMETALS, V18, P319, DOI 10.1007/s10534-005-3688-8
   Sanyal Arun J, 2002, Gastroenterology, V123, P1705, DOI 10.1053/gast.2002.36572
   Shimomura Y, 2017, INTERNAL MED, V56, P243, DOI 10.2169/internalmedicine.56.7002
   Shirato T, 2017, ARCH TOXICOL, V91, P1319, DOI 10.1007/s00204-016-1785-9
   Sica A, 2014, HEPATOLOGY, V59, P2034, DOI 10.1002/hep.26754
   Sorrentino P, 2004, J HEPATOL, V41, P751, DOI 10.1016/j.jhep.2004.07.010
   Sumida Y, 2013, FREE RADICAL RES, V47, P869, DOI 10.3109/10715762.2013.837577
   Sunny NE, 2017, TRENDS ENDOCRIN MET, V28, P250, DOI 10.1016/j.tem.2016.11.006
   Trumbo P, 2001, J AM DIET ASSOC, V101, P294, DOI 10.1016/S0002-8223(01)00078-5
   Tunçdemir M, 2017, HUM EXP TOXICOL, V36, P813, DOI 10.1177/0960327116666619
   Uddin MG, 2017, BIOL TRACE ELEM RES, V178, P189, DOI 10.1007/s12011-016-0919-5
   Valsesia A, 2016, AM J CLIN NUTR, V104, P566, DOI 10.3945/ajcn.116.137646
   Vardatsikos G, 2013, J INORG BIOCHEM, V120, P8, DOI 10.1016/j.jinorgbio.2012.11.006
   Wang XH, 2019, AM J CLIN NUTR, V110, P76, DOI 10.1093/ajcn/nqz041
NR 58
TC 27
Z9 27
U1 1
U2 7
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0946-672X
EI 1878-3252
J9 J TRACE ELEM MED BIO
JI J. Trace Elem. Med. Biol.
PD DEC
PY 2020
VL 62
AR 126635
DI 10.1016/j.jtemb.2020.126635
PG 6
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA OM4WV
UT WOS:000586028000066
PM 32932174
DA 2025-06-11
ER

PT J
AU Syrovatka, P
   Kraml, P
   Potockova, J
   Fialova, L
   Vejrazka, M
   Crkovska, J
   Andel, M
AF Syrovatka, Petr
   Kraml, Pavel
   Potockova, Jana
   Fialova, Lenka
   Vejrazka, Martin
   Crkovska, Jirina
   Andel, Michal
TI Relationship between Increased Body Iron Stores, Oxidative Stress and
   Insulin Resistance in Healthy Men
SO ANNALS OF NUTRITION AND METABOLISM
LA English
DT Article
DE Iron; Ferritin; Oxidative stress; Insulin resistance; Atherosclerosis
ID EASTERN FINNISH MEN; MYOCARDIAL-INFARCTION; SERUM FERRITIN; CAROTID
   ATHEROSCLEROSIS; METABOLIC SYNDROME; OVERLOAD AUGMENTS; RISK; DISEASE;
   BLOOD; COMMUNITIES
AB Aim: The aim of our cross-sectional study was to assess the relationships between body iron stores, oxidative stress, impaired insulin sensitivity and carotid atherosclerosis in a cohort of healthy men in primary prevention of cardiovascular disease. Methods: We examined 151 volunteers, aged 35 60 years. Anthropometric parameters, markers of metabolic syndrome, insulin resistance, inflammatory markers, parameters of oxidative stress and intima-media thickness of common carotid artery were measured. Results: Ferritin correlated positively with waist circumference, body mass index, impaired insulin sensitivity, plasma triglycerides and inversely with high-density lipoprotein cholesterol. We observed positive correlations between ferritin, oxidized low-density lipoprotein and advanced oxidation protein products after adjustment for age, waist circumference, body mass index and measured inflammatory markers (high-sensitivity C-reactive protein, fibrinogen, interleukin-6 and tumor necrosis factor-alpha). There were no significant associations between ferritin and intima-media thickness or markers of endothelial dysfunction. In a stepwise multiple regression analysis, triglycerides, waist circumference and elevated transaminases were independent determinants of the serum ferritin level. Conclusion: Our results provide evidence for a relationship between plasma ferritin and oxidative modification of lipids as well as proteins in vivo. Higher body iron stores may contribute to impaired insulin sensitivity through increased oxidative stress in a cohort of healthy men. Copyright (C) 2009 S. Karger AG, Basel
C1 [Syrovatka, Petr] Charles Univ Prague, Inst Clin & Expt Med, Dept Cardiol, CZ-14021 Prague 4, Czech Republic.
   [Syrovatka, Petr; Kraml, Pavel; Potockova, Jana; Andel, Michal] Charles Univ Prague, Fac Med 3, Dept Internal Med 2, CZ-14021 Prague 4, Czech Republic.
   [Fialova, Lenka; Vejrazka, Martin; Crkovska, Jirina] Charles Univ Prague, Fac Med 1, Dept Med Chem 1, CZ-14021 Prague 4, Czech Republic.
C3 Institute for Clinical & Experimental Medicine (IKEM); Charles
   University Prague; Charles University Prague; Charles University Prague
RP Syrovatka, P (corresponding author), Charles Univ Prague, Inst Clin & Expt Med, Dept Cardiol, Videnska 1958-9, CZ-14021 Prague 4, Czech Republic.
EM petr.syrovatka@seznam.cz
RI Andel, Michal/E-4305-2012; Vejrazka, Martin/D-2327-2017; Crkovska,
   Jirina/J-2683-2017; Fialova, Lenka/G-9419-2017
OI Vejrazka, Martin/0000-0001-5127-8975; Crkovska,
   Jirina/0000-0002-5456-5117; Fialova, Lenka/0000-0001-8137-7771
FU Ministry of Education, Czech Republic [MSM0021620814]
FX This study was supported by the research program of the Ministry of
   Education, Czech Republic, No. MSM0021620814.
CR ARAUJO JA, 1995, ARTERIOSCL THROM VAS, V15, P1172, DOI 10.1161/01.ATV.15.8.1172
   ASCHERIO A, 1994, CIRCULATION, V89, P969, DOI 10.1161/01.CIR.89.3.969
   Beard J, 2000, AM J CLIN NUTR, V72, p594S, DOI 10.1093/ajcn/72.2.594S
   Chitturi S, 2001, SEMIN LIVER DIS, V21, P27, DOI 10.1055/s-2001-12927
   Conrad ME, 2001, AM J HEMATOL, V67, P215, DOI 10.1002/ajh.1114
   Evans JL, 2003, DIABETES, V52, P1, DOI 10.2337/diabetes.52.1.1
   Facchini FS, 1998, DIABETES CARE, V21, P2190, DOI 10.2337/diacare.21.12.2190a
   Fernández-Real JM, 2005, CLIN CHEM, V51, P1201, DOI 10.1373/clinchem.2004.046847
   Fernández-Real JM, 1998, DIABETES CARE, V21, P62, DOI 10.2337/diacare.21.1.62
   Ford ES, 1999, DIABETES CARE, V22, P1978, DOI 10.2337/diacare.22.12.1978
   Harrison EH, 2005, ANNU REV NUTR, V25, P87, DOI 10.1146/annurev.nutr.25.050304.092614
   Ishizaka N, 2002, CIRCULATION, V106, P1840, DOI 10.1161/01.CIR.0000031161.77536.02
   Kartikasari AER, 2006, FASEB J, V20, P353, DOI 10.1096/fj.05-4700fje
   Kiechl S, 1997, CIRCULATION, V96, P3300
   Kyriakis JM, 1996, J BIOL CHEM, V271, P24313, DOI 10.1074/jbc.271.40.24313
   Levy JC, 1998, DIABETES CARE, V21, P2191, DOI 10.2337/diacare.21.12.2191
   Lutsey PL, 2008, CIRCULATION, V117, P754, DOI 10.1161/CIRCULATIONAHA.107.716159
   Mendler MH, 1999, GASTROENTEROLOGY, V117, P1155, DOI 10.1016/S0016-5085(99)70401-4
   MOORE M, 1995, AM J EPIDEMIOL, V141, P719, DOI 10.1093/oxfordjournals.aje.a117493
   Paz K, 1997, J BIOL CHEM, V272, P29911, DOI 10.1074/jbc.272.47.29911
   SALONEN JT, 1992, CIRCULATION, V86, P803, DOI 10.1161/01.CIR.86.3.803
   Slentz CA, 2005, J APPL PHYSIOL, V99, P1613, DOI 10.1152/japplphysiol.00124.2005
   STAMPFER MJ, 1993, CIRCULATION, V87, P688
   SULLIVAN JL, 1981, LANCET, V1, P1293
   Swaminathan S, 2007, DIABETES CARE, V30, P1926, DOI 10.2337/dc06-2625
   Trombini P, 2007, J HEPATOL, V46, P549, DOI 10.1016/j.jhep.2007.01.004
   Tuomainen TP, 1997, DIABETES CARE, V20, P426, DOI 10.2337/diacare.20.3.426
   Tuomainen TP, 1997, BRIT MED J, V314, P793, DOI 10.1136/bmj.314.7083.793
   WANG Y, 2009, INT J OBESITY, V24, P1
   WitkoSarsat V, 1996, KIDNEY INT, V49, P1304, DOI 10.1038/ki.1996.186
   You SA, 2005, CLIN CHIM ACTA, V357, P1, DOI 10.1016/j.cccn.2005.02.001
   Zacharski LR, 2007, JAMA-J AM MED ASSOC, V297, P603, DOI 10.1001/jama.297.6.603
NR 32
TC 39
Z9 40
U1 0
U2 10
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-6807
EI 1421-9697
J9 ANN NUTR METAB
JI Ann. Nutr. Metab.
PY 2009
VL 54
IS 4
BP 268
EP 274
DI 10.1159/000229507
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 511EZ
UT WOS:000271148000003
PM 19641304
DA 2025-06-11
ER

PT J
AU Ebrahimi, F
   Urwyler, SA
   Betz, MJ
   Christ, ER
   Schuetz, P
   Mueller, B
   Donath, MY
   Christ-Crain, M
AF Ebrahimi, Fahim
   Urwyler, Sandrine Andrea
   Betz, Matthias Johannes
   Christ, Emanuel Remigius
   Schuetz, Philipp
   Mueller, Beat
   Donath, Marc Yves
   Christ-Crain, Mirjam
TI Effects of interleukin-1 antagonism and corticosteroids on fibroblast
   growth factor-21 in patients with metabolic syndrome
SO SCIENTIFIC REPORTS
LA English
DT Article
ID BETA-KLOTHO EXPRESSION; PLASMA-CONCENTRATIONS; FGF21 LEVELS; ACTIVATION;
   INFLAMMATION; PROTEIN; OBESITY; ATHEROSCLEROSIS; MARKERS; STRESS
AB Fibroblast growth factor-21 (FGF21) is elevated in patients with the metabolic syndrome. Although the exact underlying mechanisms remain ill-defined, chronic low-grade inflammation with increased Interleukin-(IL)-1 beta expression may be responsible. The aim of this study was to investigate effects of two different anti-inflammatory treatments (IL-1 antagonism or high-dose corticosteroids) on FGF21 in patients with the metabolic syndrome. This is a secondary analysis of two interventional studies in patients with obesity and features of the metabolic syndrome. Trial A was an interventional trial (n=73) investigating short-term effects of the IL-1 antagonist anakinra and of dexamethasone. Trial B was a randomized, placebo-controlled, double-blinded trial (n=67) investigating longer-term effects of IL-1 antagonism. In total, 140 patients were included in both trials. Median age was 55 years (IQR 44-66), 26% were female and median BMI was 37 kg/m(2) (IQR 34-39). Almost half of the patients were diabetic (45%) and had increased c-reactive protein levels of 3.4 mg/L. FGF21 levels correlated with fasting glucose levels, HOMA-index, C-peptide levels, HbA1c and BMI. Short-term treatment with anakinra led to a reduction of FGF21 levels by - 200 pg/mL (95%CI - 334 to - 66; p=0.004). No effect was detectable after longer-term treatment (between-group difference: - 8.8 pg/mL (95%CI - 130.9 to 113.3; p=0.89). Acute treatment with dexamethasone was associated with reductions of FGF21 by -175 pg/mL (95%CI - 236 to - 113; p<0.001). Anti-inflammatory treatment with both, IL-1 antagonism and corticosteroids reduced FGF21 levels at short-term in individuals with the metabolic syndrome.Trial registration: ClinicalTrials.gov Identifiers NCT02672592 and NCT00757276.
C1 [Ebrahimi, Fahim; Urwyler, Sandrine Andrea; Betz, Matthias Johannes; Christ, Emanuel Remigius; Donath, Marc Yves; Christ-Crain, Mirjam] Univ Hosp Basel, Div Endocrinol Diabet & Metab, Basel, Switzerland.
   [Ebrahimi, Fahim; Urwyler, Sandrine Andrea; Betz, Matthias Johannes; Christ, Emanuel Remigius; Schuetz, Philipp; Mueller, Beat; Donath, Marc Yves; Christ-Crain, Mirjam] Univ Hosp Basel, Dept Clin Res, Basel, Switzerland.
   [Schuetz, Philipp; Mueller, Beat] Kantonsspital Aarau, Univ Dept Med, Div Endocrinol Diabet & Metab, Aarau, Switzerland.
   [Ebrahimi, Fahim] Univ Hosp Basel, Univ Ctr Gastrointestinal & Liver Dis, Basel, Switzerland.
C3 University of Basel; University of Basel; Kantonsspital Aarau AG (KSA);
   University of Basel
RP Ebrahimi, F (corresponding author), Univ Hosp Basel, Div Endocrinol Diabet & Metab, Basel, Switzerland.; Ebrahimi, F (corresponding author), Univ Hosp Basel, Dept Clin Res, Basel, Switzerland.; Ebrahimi, F (corresponding author), Univ Hosp Basel, Univ Ctr Gastrointestinal & Liver Dis, Basel, Switzerland.
EM f.ebrahimi@outlook.com
RI Ebrahimi, Fahim/JQI-5819-2023; Schuetz, Philipp/C-8475-2013
OI Christ-Crain, Mirjam/0000-0002-6336-0965; Urwyler, Sandrine
   Andrea/0000-0003-4056-2262; Ebrahimi, Fahim/0000-0001-5862-966X; Betz,
   Matthias Johannes/0000-0002-6946-1871; Schuetz,
   Philipp/0000-0001-6400-4949
FU Swiss National Science Foundation (SNSF, National Research Program) [NRP
   74, 407440_167376]; Swiss National Foundation [PP00P312346];
   "Wissenschaftspool 2014" of the University Hospital of Basel; University
   of Basel (Nachwuchsfoerderung 2015); "Young Talents in Clinical
   Research" program by the Bangerter Foundation; Swiss Academy of Medical
   Sciences (SAMS); "Wissenschaftspool" of the University Hospital of
   Basel; University of Basel (Nachwuchsfoerderung 2017); Swiss National
   Science Foundation (SNF) [407440_167376] Funding Source: Swiss National
   Science Foundation (SNF)
FX This study was supported in part by the Swiss National Science
   Foundation (SNSF, National Research Program (NRP 74), 407440_167376).
   This work was supported by a grant of the Swiss National Foundation (Nr
   PP00P312346) to MCC, a grant of the "Wissenschaftspool 2014" of the
   University Hospital of Basel to SU and a grant of the University of
   Basel (Nachwuchsfoerderung 2015) to SU. FE was supported by the "Young
   Talents in Clinical Research" program by the Bangerter Foundation and
   the Swiss Academy of Medical Sciences (SAMS). FE also received a grant
   of the "Wissenschaftspool" of the University Hospital of Basel and a
   grant of the University of Basel (Nachwuchsfoerderung 2017). The funding
   sources had no role in study design, data collection, data analysis,
   data interpretation, or writing of the report. FE, SAU and MCC had full
   access to all the data in the study and had final responsibility for the
   decision to submit for publication.
CR Al-Aqil FA, 2018, BBA-MOL BASIS DIS, V1864, P2927, DOI 10.1016/j.bbadis.2018.06.003
   Angelin B, 2012, CELL METAB, V16, P693, DOI 10.1016/j.cmet.2012.11.001
   Ballak DB, 2015, CYTOKINE, V75, P280, DOI 10.1016/j.cyto.2015.05.005
   Barb D, 2019, J CLIN ENDOCR METAB, V104, P3327, DOI 10.1210/jc.2018-02414
   Chau MDL, 2010, P NATL ACAD SCI USA, V107, P12553, DOI 10.1073/pnas.1006962107
   Chavez AO, 2009, DIABETES CARE, V32, P1542, DOI 10.2337/dc09-0684
   Cottam DR, 2004, OBES SURG, V14, P589, DOI 10.1381/096089204323093345
   Díaz-Delfín J, 2012, ENDOCRINOLOGY, V153, P4238, DOI 10.1210/en.2012-1193
   Dinarello CA, 2011, BLOOD, V117, P3720, DOI 10.1182/blood-2010-07-273417
   Donath MY, 2013, CELL METAB, V17, P860, DOI 10.1016/j.cmet.2013.05.001
   Donath MY, 2011, NAT REV IMMUNOL, V11, P98, DOI 10.1038/nri2925
   Dostálová I, 2008, J CLIN ENDOCR METAB, V93, P3627, DOI 10.1210/jc.2008-0746
   Dunshee DR, 2016, J BIOL CHEM, V291, P5986, DOI 10.1074/jbc.M115.710582
   Durovcová V, 2010, PHYSIOL RES, V59, P415, DOI 10.33549/physiolres.931801
   Ebert T, 2018, J CLIN ENDOCR METAB, V103, P1015, DOI 10.1210/jc.2017-02085
   Ebrahimi F, 2019, ENDOCR CONNECT, V8, P701, DOI 10.1530/EC-19-0201
   Ebrahimi F, 2019, EUR RESPIR J, V53, DOI 10.1183/13993003.00973-2018
   Ebrahimi F, 2018, J CLIN ENDOCR METAB, V103, P3466, DOI 10.1210/jc.2018-00739
   Feingold KR, 2012, ENDOCRINOLOGY, V153, P2689, DOI 10.1210/en.2011-1496
   Fisher FM, 2016, ANNU REV PHYSIOL, V78, P223, DOI 10.1146/annurev-physiol-021115-105339
   Gälman C, 2008, CELL METAB, V8, P169, DOI 10.1016/j.cmet.2008.06.014
   Gariani K, 2013, ENDOCR CONNECT, V2, DOI 10.1530/EC-13-0040
   Hanssen MJW, 2015, SCI REP-UK, V5, DOI 10.1038/srep10275
   Inagaki T, 2007, CELL METAB, V5, P415, DOI 10.1016/j.cmet.2007.05.003
   Kaiser C, 2012, RHEUMATOL INT, V32, P295, DOI 10.1007/s00296-011-2096-3
   Kim KH, 2013, NAT MED, V19, P83, DOI 10.1038/nm.3014
   Kralisch S, 2013, J ENDOCRINOL, V216, P135, DOI 10.1530/JOE-12-0367
   Lee P, 2014, CELL METAB, V19, P302, DOI 10.1016/j.cmet.2013.12.017
   Lee P, 2013, J CLIN ENDOCR METAB, V98, pE98, DOI 10.1210/jc.2012-3107
   Micanovic R, 2009, J CELL PHYSIOL, V219, P227, DOI 10.1002/jcp.21675
   Novotny D, 2014, PHYSIOL RES, V63, P219, DOI 10.33549/physiolres.932602
   Ohnishi T, 2017, SCI REP-UK, V7, DOI 10.1038/srep41130
   Patel R, 2015, MOL ENDOCRINOL, V29, P213, DOI 10.1210/me.2014-1259
   Potthoff MJ, 2009, P NATL ACAD SCI USA, V106, P10853, DOI 10.1073/pnas.0904187106
   Reinehr T, 2016, J PEDIATR-US, V173, P131, DOI 10.1016/j.jpeds.2016.02.055
   Ridker PM, 2004, CIRCULATION, V109, P2818, DOI 10.1161/01.CIR.0000132467.45278.59
   Staiger H, 2017, ENDOCR REV, V38, P468, DOI 10.1210/er.2017-00016
   Tabari FS, 2019, REV ENDOCR METAB DIS, V20, P103, DOI 10.1007/s11154-019-09488-x
   Thiessen SE, 2015, J CLIN ENDOCR METAB, V100, pE1319, DOI 10.1210/jc.2015-2700
   Urwyler SA, 2017, J CLIN ENDOCR METAB, V102, P1712, DOI 10.1210/jc.2016-3931
   van Asseldonk EJP, 2011, J CLIN ENDOCR METAB, V96, P2119, DOI 10.1210/jc.2010-2992
   Vispute SG, 2017, TOXICOLOGY, V378, P95, DOI 10.1016/j.tox.2017.01.009
   Wang N., FGF 21 PLAYS CRUCIAL, DOI [10.1007/s10753-017-0665-7, DOI 10.1007/S10753-017-0665-7]
   Yu HY, 2011, CLIN CHEM, V57, P691, DOI 10.1373/clinchem.2010.155184
   Yu YH, 2016, INT IMMUNOPHARMACOL, V38, P144, DOI 10.1016/j.intimp.2016.05.026
   Yu YH, 2015, INT IMMUNOPHARMACOL, V25, P74, DOI 10.1016/j.intimp.2015.01.005
   Zeng ZL, 2020, EXP CELL RES, V393, DOI 10.1016/j.yexcr.2020.112108
   Zhang YM, 2018, MOL MED REP, V17, P1453, DOI 10.3892/mmr.2017.8100
   Zhao YS, 2016, AM J PHYSIOL-ENDOC M, V310, pE289, DOI 10.1152/ajpendo.00356.2015
   Zhen EY, 2016, BIOCHEM J, V473, P605, DOI 10.1042/BJ20151085
NR 50
TC 2
Z9 2
U1 0
U2 1
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 12
PY 2021
VL 11
IS 1
AR 7911
DI 10.1038/s41598-021-87207-w
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA RN6AP
UT WOS:000640434400044
PM 33846498
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hattori, T
   Murase, T
   Takatsu, M
   Nagasawa, K
   Matsuura, N
   Watanabe, S
   Murohara, T
   Nagata, K
AF Hattori, Takuya
   Murase, Tamayo
   Takatsu, Miwa
   Nagasawa, Kai
   Matsuura, Natsumi
   Watanabe, Shogo
   Murohara, Toyoaki
   Nagata, Kohzo
TI Dietary Salt Restriction Improves Cardiac and Adipose Tissue Pathology
   Independently of Obesity in a Rat Model of Metabolic Syndrome
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE diet; hypertension; obesity; remodeling; sodium
ID DIASTOLIC DYSFUNCTION; HEART-FAILURE; INSULIN-RESISTANCE;
   BLOOD-PRESSURE; ANIMAL-MODEL; DAHLS.Z-LEPR(FA)/LEPR(FA) RATS;
   MINERALOCORTICOID RECEPTORS; WISTAR RATS; SODIUM; PHOSPHORYLATION
AB Background-Metabolic syndrome (MetS) enhances salt sensitivity of blood pressure and is an important risk factor for cardiovascular disease. The effects of dietary salt restriction on cardiac pathology associated with metabolic syndrome remain unclear.
   Methods and Results-We investigated whether dietary salt restriction might ameliorate cardiac injury in DahlS. Z-Leprfa/Leprfa (DS/ obese) rats, which are derived from a cross between Dahl salt-sensitive and Zucker rats and represent a model of metabolic syndrome. DS/obese rats were fed a normal-salt (0.36% NaCl in chow) or low-salt (0.0466% NaCl in chow) diet from 9 weeks of age and were compared with similarly treated homozygous lean littermates (DahlS. Z-Lepr+/Lepr+, or DS/lean rats). DS/ obese rats fed the normal-salt diet progressively developed hypertension and showed left ventricular hypertrophy, fibrosis, and diastolic dysfunction at 15 weeks. Dietary salt restriction attenuated all of these changes in DS/obese rats. The levels of cardiac oxidative stress and inflammation and the expression of cardiac renin-angiotensin-aldosterone system genes were increased in DS/obese rats fed the normal-salt diet, and dietary salt restriction downregulated these parameters in both DS/obese and DS/lean rats. In addition, dietary salt restriction attenuated the increase in visceral adipose tissue inflammation and the decrease in insulin signaling apparent in DS/ obese rats without reducing body weight or visceral adipocyte size. Dietary salt restriction did not alter fasting serum glucose levels but it markedly decreased the fasting serum insulin concentration in DS/obese rats.
   Conclusions-Dietary salt restriction not only prevents hypertension and cardiac injury but also ameliorates insulin resistance, without reducing obesity, in this model of metabolic syndrome.
C1 [Hattori, Takuya; Murase, Tamayo; Takatsu, Miwa; Nagasawa, Kai; Matsuura, Natsumi; Watanabe, Shogo; Nagata, Kohzo] Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Nagoya, Aichi, Japan.
   [Murohara, Toyoaki] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi, Japan.
C3 Nagoya University; Nagoya University
RP Nagata, K (corresponding author), Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Higashi Ku, 1-1-20 Daikominami, Nagoya, Aichi 4618673, Japan.
EM nagata@met.nagoya-u.ac.jp
RI Murohara, Toyoaki/M-4958-2014
FU Nippon Boehringer Ingelheim Co, Ltd (Tokyo, Japan); Ajinomoto
   Pharmaceuticals Co, Ltd (Tokyo, Japan); Kyowa Hakko Kirin Co Ltd (Tokyo,
   Japan); Astellas Pharma Inc (Tokyo, Japan); Mochida Pharmaceutical Co,
   Ltd (Tokyo, Japan); Mitsubishi Tanabe Pharma Corporation (Osaka, Japan);
   Takeda Pharmaceutical Company Limited (Osaka, Japan); Daiichi-Sankyo
   Company, Limited (Tokyo, Japan); Japanese Government
FX This work was supported by unrestricted research grants from Nippon
   Boehringer Ingelheim Co, Ltd (Tokyo, Japan), Ajinomoto Pharmaceuticals
   Co, Ltd (Tokyo, Japan), Kyowa Hakko Kirin Co Ltd (Tokyo, Japan),
   Astellas Pharma Inc (Tokyo, Japan), Mochida Pharmaceutical Co, Ltd
   (Tokyo, Japan), Mitsubishi Tanabe Pharma Corporation (Osaka, Japan),
   Takeda Pharmaceutical Company Limited (Osaka, Japan), Daiichi-Sankyo
   Company, Limited (Tokyo, Japan) and Dr Nagata (Nagoya University) as
   well as by Management Expenses Grants from the Japanese Government to
   Nagoya University.
CR Alderman MH, 1998, LANCET, V351, P781, DOI 10.1016/S0140-6736(97)09092-2
   Baudrand R, 2014, NUTR METAB CARDIOVAS, V24, P34, DOI 10.1016/j.numecd.2013.07.004
   Bradham WS, 2002, CARDIOVASC RES, V53, P822, DOI 10.1016/S0008-6363(01)00503-X
   Catanozi S, 2001, ATHEROSCLEROSIS, V158, P81, DOI 10.1016/S0021-9150(01)00415-4
   Chen J, 2009, LANCET, V373, P829, DOI 10.1016/S0140-6736(09)60144-6
   Cook NR, 2007, BMJ-BRIT MED J, V334, P885, DOI 10.1136/bmj.39147.604896.55
   Cuspidi C, 2004, J HYPERTENS, V22, P1991, DOI 10.1097/00004872-200410000-00023
   Denny SD, 2006, AM J MED, V119, P327, DOI [10.1016/j.amjmed.2005.08.027, 10.1016/j.amjmed.2005.10.042]
   DYER AR, 1994, HYPERTENSION, V23, P729, DOI 10.1161/01.HYP.23.6.729
   ELLIOTT P, 1988, BRIT MED J, V297, P319
   Fujita T, 2010, HYPERTENSION, V55, P813, DOI 10.1161/HYPERTENSIONAHA.109.149062
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Haruta T, 2000, MOL ENDOCRINOL, V14, P783, DOI 10.1210/me.14.6.783
   Hattori T, 2011, NUTR DIABETES, V1, DOI 10.1038/nutd.2010.1
   Hattori T, 2014, HYPERTENS RES, V37, P125, DOI 10.1038/hr.2013.124
   He FJ, 2009, J HUM HYPERTENS, V23, P363, DOI 10.1038/jhh.2008.144
   Ichihara S, 2006, CARDIOVASC RES, V69, P726, DOI 10.1016/j.cardiores.2005.08.001
   Kamei N, 2006, J BIOL CHEM, V281, P26602, DOI 10.1074/jbc.M601284200
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Matsui H, 2008, HYPERTENSION, V52, P287, DOI 10.1161/HYPERTENSIONAHA.108.111815
   Matsuzawa Y, 2006, NAT CLIN PRACT CARD, V3, P35, DOI 10.1038/ncpcardio0380
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Meléndez GC, 2010, HYPERTENSION, V56, P225, DOI 10.1161/HYPERTENSIONAHA.109.148635
   Miyachi M, 2009, HYPERTENSION, V53, P701, DOI 10.1161/HYPERTENSIONAHA.108.127290
   Murase T, 2012, HYPERTENSION, V59, P694, DOI 10.1161/HYPERTENSIONAHA.111.180976
   Murase T, 2012, HYPERTENS RES, V35, P186, DOI 10.1038/hr.2011.157
   Nagata K, 2006, HYPERTENSION, V47, P656, DOI 10.1161/01.HYP.0000203772.78696.67
   Nagata K, 2002, HYPERTENSION, V40, P168, DOI 10.1161/01.HYP.0000026668.50222.1E
   NAGATA K, 1995, J AM COLL CARDIOL, V25, P295, DOI 10.1016/0735-1097(94)00369-2
   Ogihara T, 2002, HYPERTENSION, V40, P83, DOI 10.1161/01.HYP.0000022880.45113.C9
   Prada PD, 2000, HYPERTENSION, V35, P424, DOI 10.1161/01.HYP.35.1.424
   Prada PO, 2005, J ENDOCRINOL, V185, P429, DOI 10.1677/joe.1.06028
   Reffelmann T, 2003, BASIC RES CARDIOL, V98, P275, DOI 10.1007/s00395-003-0401-3
   ROCCHINI AP, 1989, NEW ENGL J MED, V321, P580, DOI 10.1056/NEJM198908313210905
   Sakata Y, 2004, CIRCULATION, V109, P2143, DOI 10.1161/01.CIR.0000125741.88712.77
   Schmid C, 1997, HYPERTENSION, V29, P923, DOI 10.1161/01.HYP.29.4.923
   Shimamoto K, 2014, HYPERTENS RES, V37, P256, DOI [10.1038/hr.2014.20, 10.1038/hr.2014.18]
   Somura F, 2001, CIRCULATION, V104, P658, DOI 10.1161/hc3101.093869
   Stolarz-Skrzypek K, 2011, JAMA-J AM MED ASSOC, V305, P1777, DOI 10.1001/jama.2011.574
   Takatsu M, 2013, HYPERTENSION, V62, P957, DOI 10.1161/HYPERTENSIONAHA.113.02093
   Townsend RR, 2007, CLIN SCI, V113, P141, DOI 10.1042/CS20060361
   Ueno M, 2005, DIABETOLOGIA, V48, P506, DOI 10.1007/s00125-004-1662-6
   Weber KT, 2004, HYPERTENSION, V43, P716, DOI 10.1161/01.HYP.0000118586.38323.5b
   Yudkin JS, 1999, ARTERIOSCL THROM VAS, V19, P972, DOI 10.1161/01.ATV.19.4.972
NR 44
TC 38
Z9 39
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD DEC
PY 2014
VL 3
IS 6
AR e001312
DI 10.1161/JAHA.114.001312
PG 14
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA V61EX
UT WOS:000210882600026
PM 25468654
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Banderas, DZ
   Escobedo, J
   Gonzalez, E
   Liceaga, MG
   Ramírez, JC
   Castro, MG
AF Zaineff Banderas, Diana
   Escobedo, Jorge
   Gonzalez, Evangelina
   Gabriela Liceaga, Maria
   Cenobio Ramirez, Jesus
   Guadalupe Castro, Maria
TI γ-Glutamyl transferase: a marker of nonalcoholic fatty liver disease in
   patients with the metabolic syndrome
SO EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
LA English
DT Article
DE gamma-glutamyltransferase; metabolic syndrome; nonalcoholic fatty liver
   disease; population-based cross-sectional study; risk factors
ID ALANINE AMINOTRANSFERASE; INSULIN-RESISTANCE; VISCERAL FAT; HEART; MEN;
   DEFINITION; PREDICTOR; SEVERITY; EVENTS; HEALTH
AB Objective The incidence of metabolic syndrome has increased in Mexico and nonalcoholic fatty liver disease (NAFLD) is a common complication. The authors aimed to evaluate the role of hepatic enzymes as biomarkers for NAFLD in patients presenting metabolic syndrome.
   Methods We studied 193 nondiabetic individuals with metabolic syndrome identified from a population-based cross-sectional survey. To identify NAFLD, real-time gray-scale abdominal ultrasound was performed, and the right, left, and caudate hepatic lobules were observed to assess the size, echogenicity, and borders of the liver. All individuals answered a questionnaire for risk factors, and anthropometric measures and blood pressure were obtained. The concentration of hepatic enzymes and insulin in blood was measured and the Homeostatic Model Assessment index was calculated.
   Results A total of 160 individuals were identified as presenting NAFLD (82.9%). Body weight, BMI, and the waist-hip ratio increased as a direct result of the presence and severity of fatty liver. A similar situation was observed in the levels of triglyceride and hepatic enzymes aspartate aminotransferase and gamma-glutamyltransferase (GGT), basal insulin level, and the Homeostatic Model Assessment index. In a multivariate model, the variables associated with the occurrence of NAFLD were sex, triglyceride and GGT levels, and obesity.
   Conclusion The main factors that predict the occurrence of NAFLD are levels of triglyceride and GGT in the blood, as well as obesity. The accumulation of fat in the liver, in addition to increased oxidation and oxidative stress at the hepatic level, may be the mechanisms through which these factors increase the risk of NAFLD. Eur J Gastroenterol Hepatol 24:805-810 (c) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Escobedo, Jorge; Gonzalez, Evangelina] Mexican Inst Social Secur, Reg Hosp 1, Clin Res Ctr, Mexico City 03100, DF, Mexico.
   [Zaineff Banderas, Diana; Escobedo, Jorge; Gabriela Liceaga, Maria; Guadalupe Castro, Maria] Mexican Inst Social Secur, Dept Internal Med, Mexico City 03100, DF, Mexico.
   [Cenobio Ramirez, Jesus] Mexican Inst Social Secur, La Raza Med Ctr, Gen Hosp, Dept Radiol, Mexico City 03100, DF, Mexico.
C3 Instituto Mexicano del Seguro Social; Instituto Mexicano del Seguro
   Social; Instituto Mexicano del Seguro Social
RP Escobedo, J (corresponding author), Mexican Inst Social Secur, Reg Hosp 1, Clin Res Ctr, Gabriel Mancera 222, Mexico City 03100, DF, Mexico.
EM jorgeep@unam.mx
RI Escobedo, Jorge/AAH-3917-2020
OI Banderas Lares, Diana Zaineff/0000-0002-8186-3101; Castro, Maria
   Graciela/0000-0003-2237-2756; Escobedo, Jorge/0000-0003-1942-7402
CR André P, 2007, DIABETES CARE, V30, P2355, DOI 10.2337/dc07-0440
   Angelico F, 2005, J CLIN ENDOCR METAB, V90, P1578, DOI 10.1210/jc.2004-1024
   Charatcharoenwitthaya P, 2007, CLIN LIVER DIS, V11, P1137
   Cheung O, 2007, HEPATOLOGY, V46, P1091, DOI 10.1002/hep.21803
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Diehl AM, 2010, GASTROENTEROL CLIN N, V39, P57, DOI 10.1016/j.gtc.2009.12.001
   Dominici S, 2003, BIOFACTORS, V17, P187, DOI 10.1002/biof.5520170118
   Edmison John, 2007, Clin Liver Dis, V11, P75, DOI 10.1016/j.cld.2007.02.011
   Escobedo J, 2009, CARDIOVASC DIABETOL, V8, DOI 10.1186/1475-2840-8-52
   Fraser A, 2007, ARTERIOSCL THROM VAS, V27, P2729, DOI 10.1161/ATVBAHA.107.152298
   Hamaguchi M, 2005, ANN INTERN MED, V143, P722, DOI 10.7326/0003-4819-143-10-200511150-00009
   Jeong SK, 2008, J KOREAN MED SCI, V23, P789, DOI 10.3346/jkms.2008.23.5.789
   Kashyap SR, 2009, OBESITY, V17, P1696, DOI 10.1038/oby.2009.89
   Koike T, 2010, OBES RES CLIN PRACT, V4, pE73, DOI 10.1016/j.orcp.2009.09.003
   Lee DS, 2007, ARTERIOSCL THROM VAS, V27, P127, DOI 10.1161/01.ATV.0000251993.20372.40
   Liangpunsakul S, 2005, AM J MED SCI, V329, P111, DOI 10.1097/00000441-200503000-00001
   London Roslyn M, 2007, Clin Liver Dis, V11, P55, DOI 10.1016/j.cld.2007.02.010
   Mason Jennifer E, 2010, Prev Cardiol, V13, P36, DOI 10.1111/j.1751-7141.2009.00054.x
   Meisinger C, 2006, ATHEROSCLEROSIS, V189, P297, DOI 10.1016/j.atherosclerosis.2006.01.010
   Musso G, 2008, DIABETES CARE, V31, P562, DOI 10.2337/dc07-1526
   Nannipieri M, 2005, DIABETES CARE, V28, P1757, DOI 10.2337/diacare.28.7.1757
   Ong Janus P, 2007, Clin Liver Dis, V11, P1, DOI 10.1016/j.cld.2007.02.009
   Schindhelm RK, 2006, DIABETES-METAB RES, V22, P437, DOI 10.1002/dmrr.666
   Speliotes EK, 2010, HEPATOLOGY, V51, P1979, DOI 10.1002/hep.23593
   Tsai CH, 2008, SOUTH MED J, V101, P900, DOI 10.1097/SMJ.0b013e31817e8af9
   Uslusoy HS, 2009, WORLD J GASTROENTERO, V15, P1863, DOI 10.3748/wjg.15.1863
NR 27
TC 51
Z9 60
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0954-691X
EI 1473-5687
J9 EUR J GASTROEN HEPAT
JI Eur. J. Gastroenterol. Hepatol.
PD JUL
PY 2012
VL 24
IS 7
BP 805
EP 810
DI 10.1097/MEG.0b013e328354044a
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 956HN
UT WOS:000305080800012
PM 22546752
DA 2025-06-11
ER

PT J
AU Goodrich, KM
   Fundaro, G
   Griffin, LE
   Grant, A
   Hulver, MW
   Ponder, MA
   Neilson, AP
AF Goodrich, Katheryn M.
   Fundaro, Gabrielle
   Griffin, Laura E.
   Grant, Ar'Quette
   Hulver, Matthew W.
   Ponder, Monica A.
   Neilson, Andrew P.
TI Chronic administration of dietary grape seed extract increases colonic
   expression of gut tight junction protein occludin and reduces fecal
   calprotectin: a secondary analysis of healthy Wistar Furth rats
SO NUTRITION RESEARCH
LA English
DT Article
DE Calprotectin; Colon; Endotoxins; Grape seed extract; Metabolic syndrome;
   Obesity; Procyanidin; Tight junctions; Wistar Furth rat
ID HIGH-FAT-DIET; INTESTINAL PERMEABILITY; INDUCED OBESITY;
   GASTROINTESTINAL-TRACT; MICROBIAL ECOLOGY; OXIDATIVE STRESS;
   SKELETAL-MUSCLE; GENE-EXPRESSION; PREVENT OBESITY; ADIPOSE-TISSUE
AB Animal studies have demonstrated the potential of grape seed extract (GSE) to prevent metabolic syndrome, obesity, and type 2 diabetes. Recently, metabolic endotoxemia induced by bacterial endotoxins produced in the colon has emerged as a possible factor in the etiology of metabolic syndrome. Improving colonic barrier function may control endotoxemia by reducing endotoxin uptake. However, the impact of GSE on colonic barrier integrity and endotoxin uptake has not been evaluated. We performed a secondary analysis of samples collected from a chronic GSE feeding study with pharmacokinetic end points to examine potential modulation of biomarkers of colonic integrity and endotoxin uptake. We hypothesized that a secondary analysis would indicate that chronic GSE administration increases colonic expression of intestinal tight junction proteins and reduces circulating endotoxin levels, even in the absence of an obesity-promoting stimulus. Wistar Furth rats were administered drinking water containing 0.1% GSE for 21 days. Grape seed extract significantly increased the expression of gut junction protein occludin in the proximal colon and reduced fecal levels of the neutrophil protein calprotectin, compared with control. Grape seed extract did not significantly reduce serum or fecal endotoxin levels compared with control, although the variability in serum levels was widely increased by GSE. These data suggest that the improvement of gut barrier integrity and potential modulation of endotoxemia warrant investigation as a possible mechanism by which GSE prevents metabolic syndrome and associated diseases. Further investigation of this mechanism in high-fat feeding metabolic syndrome and obesity models is therefore justified. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Goodrich, Katheryn M.; Griffin, Laura E.; Grant, Ar'Quette; Ponder, Monica A.; Neilson, Andrew P.] Virginia Polytech Inst & State Univ, Dept Food Sci & Technol, Blacksburg, VA 24061 USA.
   [Fundaro, Gabrielle; Hulver, Matthew W.] Virginia Polytech Inst & State Univ, Dept Human Nutr Foods & Exercise, Blacksburg, VA 24061 USA.
C3 Virginia Polytechnic Institute & State University; Virginia Polytechnic
   Institute & State University
RP Neilson, AP (corresponding author), Virginia Polytech Inst & State Univ, Dept Food Sci & Technol, Blacksburg, VA 24061 USA.
EM andrewn@vt.edu
RI Griffin, Laura/K-9057-2019
OI Griffin, Laura/0000-0002-9808-5019; Neilson, Andrew/0000-0001-5497-663X
FU Department of Food Science and Technology; College of Agriculture and
   Life Sciences
FX The authors thank Pamela Mohr, Pam Suroski, and Charles Nwaihesie for
   their assistance with animal husbandry. This study was supported by the
   Department of Food Science and Technology and the College of Agriculture
   and Life Sciences through startup funds provided to Andrew Neilson at
   Virginia Polytechnic Institute and State University.
CR Abia R, 2001, J SCI FOOD AGR, V81, P1156, DOI 10.1002/jsfa.924
   Baba S, 2002, FREE RADICAL BIO MED, V33, P142, DOI 10.1016/S0891-5849(02)00871-7
   Berggren S, 2007, MOL PHARM, V4, P252, DOI 10.1021/mp0600687
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Carrasco-Pozo C, 2011, J AGR FOOD CHEM, V59, P6459, DOI 10.1021/jf200553s
   Chuang CC, 2011, ANNU REV NUTR, V31, P155, DOI 10.1146/annurev-nutr-072610-145149
   Creely SJ, 2007, AM J PHYSIOL-ENDOC M, V292, pE740, DOI 10.1152/ajpendo.00302.2006
   de Kort S, 2011, OBES REV, V12, P449, DOI 10.1111/j.1467-789X.2010.00845.x
   Decorde K, 2009, AGRO FOOD IND HI TEC, V20, P22
   Décorde K, 2009, MOL NUTR FOOD RES, V53, P659, DOI 10.1002/mnfr.200800165
   Deprez S, 2001, ANTIOXID REDOX SIGN, V3, P957, DOI 10.1089/152308601317203503
   Ding SL, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012191
   Donovan JL, 2002, BRIT J NUTR, V87, P299, DOI 10.1079/BJN2001517
   Frisard MI, 2010, AM J PHYSIOL-ENDOC M, V298, pE988, DOI 10.1152/ajpendo.00307.2009
   Glebov OK, 2003, CANCER EPIDEM BIOMAR, V12, P755
   Lam YY, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034233
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lee HC, 2006, RES MICROBIOL, V157, P876, DOI 10.1016/j.resmic.2006.07.004
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Meddings JB, 1999, AM J PHYSIOL-GASTR L, V276, pG951, DOI 10.1152/ajpgi.1999.276.4.G951
   Ménard S, 2010, MUCOSAL IMMUNOL, V3, P247, DOI 10.1038/mi.2010.5
   Milde AM, 2003, SCAND J LAB ANIM SCI, V30, P169
   Montagut G, 2010, J NUTR BIOCHEM, V21, P961, DOI 10.1016/j.jnutbio.2009.08.001
   Pajuelo D, 2011, J AGR FOOD CHEM, V59, P4279, DOI 10.1021/jf200322x
   Pajuelo D, 2012, BRIT J NUTR, V107, P170, DOI 10.1017/S0007114511002728
   Pajuelo D, 2011, J AGR FOOD CHEM, V59, P8491, DOI 10.1021/jf201775v
   Quesada H, 2011, BR J NUTR, P1
   Reheman A, 2010, THROMB RES, V125, pE177, DOI 10.1016/j.thromres.2010.01.009
   Sakurai T, 2010, J NUTR BIOCHEM, V21, P47, DOI 10.1016/j.jnutbio.2008.10.003
   Sano A, 2003, BIOSCI BIOTECH BIOCH, V67, P1140, DOI 10.1271/bbb.67.1140
   Song PX, 2011, J AGR FOOD CHEM, V59, P6227, DOI 10.1021/jf200120y
   Stoupi S, 2010, DRUG METAB DISPOS, V38, P287, DOI 10.1124/dmd.109.030304
   Terra X, 2011, J NUTR BIOCHEM, V22, P380, DOI 10.1016/j.jnutbio.2010.03.006
   Terra X, 2009, J NUTR BIOCHEM, V20, P210, DOI 10.1016/j.jnutbio.2008.02.005
   Teshima Christopher W, 2008, Curr Gastroenterol Rep, V10, P443, DOI 10.1007/s11894-008-0083-y
   Thörn M, 2005, BRIT J CLIN PHARMACO, V60, P54, DOI 10.1111/j.1365-2125.2005.02389.x
   Tsang C, 2005, BRIT J NUTR, V94, P170, DOI 10.1079/BJN20051480
   Tzounis X, 2008, BRIT J NUTR, V99, P782, DOI 10.1017/S0007114507853384
   Way JM, 2001, ENDOCRINOLOGY, V142, P1269, DOI 10.1210/en.142.3.1269
NR 43
TC 43
Z9 57
U1 2
U2 30
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD OCT
PY 2012
VL 32
IS 10
BP 787
EP 794
DI 10.1016/j.nutres.2012.09.004
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 044VX
UT WOS:000311654400008
PM 23146776
DA 2025-06-11
ER

PT J
AU Vaudo, G
   Marchesi, S
   Siepi, D
   Brozzetti, M
   Mannarino, MR
   Pirro, M
   Schillaci, G
   Ciuffetti, G
   Lupattelli, G
   Mannarino, E
AF Vaudo, Gaetano
   Marchesi, Simona
   Siepi, Donatella
   Brozzetti, Matteo
   Mannarino, Massimo Raffaele
   Pirro, Matteo
   Schillaci, Giuseppe
   Ciuffetti, Giovanni
   Lupattelli, Graziana
   Mannarino, Elmo
TI Metabolic syndrome and preclinical atherosclerosis: focus on femoral
   arteries
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID INTIMA-MEDIA THICKNESS; HIGH-DENSITY-LIPOPROTEINS; MIDDLE-AGED MEN;
   CAROTID-ARTERY; NITRIC-OXIDE; ENDOTHELIAL DYSFUNCTION;
   CARDIOVASCULAR-DISEASE; LIPID-PEROXIDATION; INSULIN-RESISTANCE;
   OXIDATIVE STRESS
AB Several evidences revealed the relationship between the earliest stages of atherosclerosis and the components of metabolic syndrome. The aim of this study was to disclose preclinical atherosclerotic lesions in a cross-sectional observational study involving 147 patients with metabolic syndrome by the assessment of brachial flow mediated vasodilation (FMV) and intima-media thickening at both carotid and femoral sites. The purpose was to investigate the association of this metabolic disorder with prevalent atherosclerotic damage in different vascular sites. A control group of 87 healthy subjects was also investigated. Patients had lower values of FMV and a higher mean intima-media thickness (IMT) at both the carotid and femoral sites with respect to controls. Flow-mediated vasodilation had a positive correlation with high-density lipoprotein (HDL) cholesterol and a negative one with low-density lipoprotein (LDL) cholesterol, glycemia, and insulinemia. Carotid mean IMT was directly related to LDL cholesterol and age, and inversely with HDL cholesterol; femoral mean IMT had a direct association with LDL cholesterol, triglycerides, glycemia, and insulinemia and an inverse correlation with HDL cholesterol and LDL size. LDL cholesterol, HDL cholesterol, insulin, and brachial artery diameter were predictive of brachial FMV (beta = -0.17, 0.21, -0.27, and -0.29, respectively; P < .05), whereas age, LDL cholesterol, and HDL cholesterol were independent predictors of mean carotid IMT (beta = 0.19, 0.37, and -0.27, respectively; P < .05); on the other hand, LDL cholesterol, triglycerides, and insulin were independent predictors of mean femoral IMT (beta = 0.32, 0.26, and 0.25, respectively; P < .05). In conclusion, the present study documented an altered endothelial function and intima-media thickening in patients with metabolic syndrome without overt cardiovascular disease. Moreover, it focused on the strong influence of metabolic syndrome on preclinical atherosclerotic lesions at the femoral site. (c) 2007 Elsevier Ins. All rights reserved.
C1 Univ Perugia, Sch Med, S Maria Misericordia Hosp, I-06100 Perugia, Italy.
C3 University of Perugia
RP Vaudo, G (corresponding author), Univ Perugia, Sch Med, S Maria Misericordia Hosp, Piazzale Menghini 1, I-06100 Perugia, Italy.
EM gvaudo@unipg.it
RI Vaudo, Gaetano/AAC-4823-2022; Pirro, Matteo/AAC-2318-2022; Mannarino,
   Massimo Raffaele/AAX-6002-2021; Mannarino, Massimo Raffaele/J-4577-2012
OI Mannarino, Massimo Raffaele/0000-0003-4694-5504; Pirro,
   Matteo/0000-0002-5527-4821; Vaudo, Gaetano/0000-0002-3176-2038;
   mannarino, elmo/0000-0002-9771-8056
CR Aldhahi Waleed, 2003, Curr Diab Rep, V3, P293, DOI 10.1007/s11892-003-0020-2
   Arcaro G, 2002, CIRCULATION, V105, P576, DOI 10.1161/hc0502.103333
   BonithonKopp C, 1997, AM J CLIN NUTR, V65, P121, DOI 10.1093/ajcn/65.1.121
   Brites FD, 2004, ARCH MED RES, V35, P235, DOI 10.1016/j.arcmed.2004.02.002
   Calabresi L, 2003, ARTERIOSCL THROM VAS, V23, P1724, DOI 10.1161/01.ATV.0000094961.74697.54
   Carmena R, 2004, CIRCULATION, V109, P2, DOI 10.1161/01.CIR.0000131511.50734.44
   Clapp BR, 2004, CARDIOVASC RES, V64, P172, DOI 10.1016/j.cardiores.2004.06.020
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P685
   Fukuchi M, 2002, LAB INVEST, V82, P1437, DOI 10.1097/01.LAB.0000032546.01658.5D
   Gorter PM, 2004, ATHEROSCLEROSIS, V173, P363, DOI 10.1016/j.atherosclerosis.2003.12.033
   Grundy Scott M, 2004, J Am Coll Cardiol, V44, P720, DOI 10.1016/j.jacc.2004.07.001
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Hidvégi T, 2003, DIABETES NUTR METAB, V16, P139
   Hulthe J, 2000, ARTERIOSCL THROM VAS, V20, P2140, DOI 10.1161/01.ATV.20.9.2140
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Kaplan M, 2001, ARTERIOSCL THROM VAS, V21, P386, DOI 10.1161/01.ATV.21.3.386
   Klafter R, 2000, J INVEST DERM SYMP P, V5, P79, DOI 10.1046/j.1087-0024.2000.00007.x
   Kontush A, 2003, ARTERIOSCL THROM VAS, V23, P1881, DOI 10.1161/01.ATV.0000091338.93223.E8
   Konukoglu D, 1998, CLIN CHIM ACTA, V277, P91, DOI 10.1016/S0009-8981(98)00117-X
   Kröger K, 1999, ANGIOLOGY, V50, P649, DOI 10.1177/000331979905000805
   Kuivenhoven JA, 2003, ATHEROSCLEROSIS, V171, P311, DOI 10.1016/j.atherosclerosis.2003.08.014
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lassègue B, 2004, AM J HYPERTENS, V17, P852, DOI 10.1016/j.amjhyper.2004.02.004
   Liu ML, 2004, ARTERIOSCL THROM VAS, V24, P1492, DOI 10.1161/01.ATV.0000135982.60383.48
   Lupattelli G, 2002, AM HEART J, V143, P733, DOI 10.1067/mhj.2002.120302
   Lupattelli G, 2000, AM HEART J, V140, P521, DOI 10.1067/mhj.2000.108508
   Marchesi S, 2000, ATHEROSCLEROSIS, V153, P397, DOI 10.1016/S0021-9150(00)00415-9
   Meredith IT, 1996, AM J PHYSIOL-HEART C, V270, pH1435, DOI 10.1152/ajpheart.1996.270.4.H1435
   Mowat BF, 1997, ATHEROSCLEROSIS, V131, P161, DOI 10.1016/S0021-9150(97)06097-8
   NEWALL RG, 1973, ANGIOLOGY, V24, P297, DOI 10.1177/000331977302400505
   Parker RA, 2003, ATHEROSCLEROSIS, V169, P19, DOI 10.1016/S0021-9150(03)00100-X
   Robbesyn F, 2003, FASEB J, V17, P743, DOI 10.1096/fj.02-0240fje
   Scuteri A, 2004, J AM COLL CARDIOL, V43, P1388, DOI 10.1016/j.jacc.2003.10.061
   SIGURDARDOTTIR V, 2006, ATHEROSCLEROSIS
   Thomas GN, 2004, ARTERIOSCL THROM VAS, V24, P739, DOI 10.1161/01.ATV.0000118015.26978.07
   Urbina EM, 2002, AM J CARDIOL, V90, P953, DOI 10.1016/S0002-9149(02)02660-7
   Vaudo G, 2000, AM J HYPERTENS, V13, P324, DOI 10.1016/S0895-7061(99)00229-0
   Wallenfeldt K, 2004, STROKE, V35, P2248, DOI 10.1161/01.STR.0000140629.65145.3c
   Wilson PWF, 2005, CIRCULATION, V112, P3066, DOI 10.1161/CIRCULATIONAHA.105.539528
   Wyne Kathleen L., 2003, American Journal of Medicine, V115, p29S
   Xia P, 1999, J BIOL CHEM, V274, P33143, DOI 10.1074/jbc.274.46.33143
NR 41
TC 18
Z9 19
U1 0
U2 1
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD APR
PY 2007
VL 56
IS 4
BP 541
EP 546
DI 10.1016/j.metabol.2006.11.016
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 153CJ
UT WOS:000245409000018
PM 17379014
DA 2025-06-11
ER

PT J
AU Pal, R
   Singh, SN
   Chatterjee, A
   Saha, M
AF Pal, Rameswar
   Singh, Som Nath
   Chatterjee, Abhirup
   Saha, Mantu
TI Age-related changes in cardiovascular system, autonomic functions, and
   levels of BDNF of healthy active males: role of yogic practice
SO AGE
LA English
DT Article
DE Yoga; Aging; Cardiovascular system; Autonomic function; BDNF
ID HEART-RATE-VARIABILITY; BLOOD-PRESSURE; OXIDATIVE STRESS; LIPID PROFILE;
   EXERCISE; MEDITATION; TRIAL; COGNITION; INDEXES; WEIGHT
AB Aging is associated with decline in cardiovascular, autonomic function, and brain-derived neurotropic factor (BDNF). Reports are scanty regarding whether yoga can improve age-related degenerative changes in healthy active men. This study is designed to appraise the role of yoga in improving age-related degenerative changes in cardiometabolic risk profile, autonomic function, stress, and BDNF. Healthy active males of three age groups (20-29, 30-39, and 40-49 years) were randomly assigned to practice yoga daily 1 h for 3 months. Significantly higher values of heart rate (HR), blood pressure (BP), load in heart (DoP), myocardial oxygen consumption (RPP), and total cholesterol (TC) were noted in senior age group. HR, BP, DoP, RPP, and TC decreased significantly following yogic practice. High frequency (HF), total power (TP), all time domain variables of heart rate variability (HRV), and skin conductance (SC) were significantly decreased with advancement of age. HF, TP, and time domain parameters of HRV and SC increased significantly following yogic practice. Higher levels of catecholamines and low frequency (LF) power of HRV was noted with advancement of age. Levels of catecholamines and LF significantly decreased following yogic practice. Cortisol and adrenocorticotropic hormone (ACTH) level raised in senior age group. BDNF, serotonin, and dopamine were low in higher age group. Significant decrement of cortisol; ACTH; and increment in serotonin, dopamine, and BDNF was noted following yogic practice. This study revealed that yogic practices might help in the prevention of age-related degeneration by changing cardiometabolic risk factors, autonomic function, and BDNF in healthy male.
C1 [Pal, Rameswar; Chatterjee, Abhirup] Def Inst Physiol & Allied Sci DIPAS, Ctr Adv Res & Training Yoga CARTY, Delhi 110054, India.
   [Singh, Som Nath] Def Inst Physiol & Allied Sci DIPAS, Nutr Div, Delhi 110054, India.
   [Saha, Mantu] Def Inst Physiol & Allied Sci DIPAS, Delhi 110054, India.
C3 Defence Research & Development Organisation (DRDO); Defence Institute of
   Physiology & Allied Sciences (DIPAS); Defence Research & Development
   Organisation (DRDO); Defence Institute of Physiology & Allied Sciences
   (DIPAS); Defence Research & Development Organisation (DRDO); Defence
   Institute of Physiology & Allied Sciences (DIPAS)
RP Saha, M (corresponding author), Def Inst Physiol & Allied Sci DIPAS, Lucknow Rd, Delhi 110054, India.
EM wpy.dipas@gmail.com
RI Saha, Mantu/V-8424-2019; Pal, Rameswar/AAU-5337-2020
OI Pal, Rameswar/0000-0001-6452-0951; Chatterjee, Dr
   Abhirup/0000-0001-5777-5390
CR ACHESON A, 1995, NATURE, V374, P450, DOI 10.1038/374450a0
   Akçakoyun F, 2010, AFR J PHARM PHARMACO, V4, P829
   Alexeyev MF, 2004, CLIN SCI, V107, P355, DOI 10.1042/CS20040148
   [Anonymous], 2011, COMPLEMENT THER CLIN, DOI 10.1016/j.ctcp.2010.09.007
   Barontini M, 1997, ARCH GERONTOL GERIAT, V25, P175, DOI 10.1016/S0167-4943(97)00008-3
   Beck LH, 1998, CLIN GERIATR MED, V14, P199
   Bekaert S, 2005, ANTICANCER RES, V25, P3011
   Bera T. K., 1993, Indian Journal of Physiology and Pharmacology, V37, P225
   BOTWINICK J, 1960, J GERONTOL, V15, P83, DOI 10.1093/geronj/15.1.83
   Bowman AJ, 1997, EUR J CLIN INVEST, V27, P443, DOI 10.1046/j.1365-2362.1997.1340681.x
   Burzynski SR, 2005, MED HYPOTHESES, V64, P201, DOI 10.1016/j.mehy.2004.06.010
   Cacioppo J.T., 1997, Annual Review of Gerontology and Geriatrics, V17, P27, DOI DOI 10.1146/ANNUREV.PSYCH.50.1.191
   Chung SC, 2012, J ALTERN COMPLEM MED, V18, P589, DOI 10.1089/acm.2011.0038
   DELMONTE MM, 1985, NEUROSCI BIOBEHAV R, V9, P557, DOI 10.1016/0149-7634(85)90002-8
   Dreher J, 2008, PNAS, V105
   Eckberg DL, 1997, CIRCULATION, V96, P3224, DOI 10.1161/01.CIR.96.9.3224
   Erickson KI, 2010, J NEUROSCI, V30, P5368, DOI 10.1523/JNEUROSCI.6251-09.2010
   Essig F, 2004, J EXERC PHYSL, V7, P37
   Fagard R H, 2001, Verh K Acad Geneeskd Belg, V63, P57
   Farley A, 2006, Nurs Stand, V20, P46
   Fraser R, 1999, HYPERTENSION, V33, P1364, DOI 10.1161/01.HYP.33.6.1364
   Frisard M, 2006, ENDOCRINE, V29, P27, DOI 10.1385/ENDO:29:1:27
   Froeliger Brett, 2012, Evid Based Complement Alternat Med, V2012, P680407, DOI 10.1155/2012/680407
   Garau C, 2006, EXP GERONTOL, V41, P40, DOI 10.1016/j.exger.2005.09.010
   GOBEL FL, 1978, CIRCULATION, V57, P549, DOI 10.1161/01.CIR.57.3.549
   Gordon LA, 2008, BMC COMPLEM ALTERN M, V8, DOI 10.1186/1472-6882-8-21
   Gothe N, 2013, J PHYS ACT HEALTH, V10, P488, DOI 10.1123/jpah.10.4.488
   Huang EJ, 2001, ANNU REV NEUROSCI, V24, P677, DOI 10.1146/annurev.neuro.24.1.677
   Huang FJ, 2013, J NURS RES, V21, P59, DOI 10.1097/jnr.0b013e3182829d6d
   JensenUrstad K, 1997, ACTA PHYSIOL SCAND, V160, P235, DOI 10.1046/j.1365-201X.1997.00142.x
   Kirk-Sanchez NJ, 2014, CLIN INTERV AGING, V9, DOI 10.2147/CIA.S39506
   Kumar K, 2009, INDIAN J TRADIT KNOW, V8, P453
   Kuzina I N, 2010, Fiziol Cheloveka, V36, P101
   LANDAHL S, 1986, HYPERTENSION, V8, P1044, DOI 10.1161/01.HYP.8.11.1044
   Leosco D, 2013, FRONT PHYSIOL, V4, DOI 10.3389/fphys.2013.00348
   Lommatzsch M, 2005, NEUROBIOL AGING, V26, P115, DOI 10.1016/j.neurobiolaging.2004.03.002
   Madanmohan U.Kaviraja., 2005, Indian J. Physiol. Pharmacol, V49, P313
   Malaguarnera M, 1998, Eur Rev Med Pharmacol Sci, V2, P75
   Malliani A, 1997, CIRCULATION, V96, P4143
   Massin MM, 1999, CARDIOLOGY, V91, P109, DOI 10.1159/000006889
   Mühlberg W, 1999, GERONTOLOGY, V45, P243, DOI 10.1159/000022097
   Murugesan R., 2000, Indian Journal of Physiology and Pharmacology, V44, P207
   Naveen GH, 2013, INDIAN J PSYCHIAT, V55, pS400, DOI 10.4103/0019-5545.116313
   Oken BS, 2006, ALTERN THER HEALTH M, V12, P40
   Oken BS, 2004, NEUROLOGY, V62, P2058, DOI 10.1212/01.WNL.0000129534.88602.5C
   Panjwani Usha, 1995, Indian Journal of Physiology and Pharmacology, V39, P111
   Papp Marian E, 2013, BMC Res Notes, V6, P59, DOI 10.1186/1756-0500-6-59
   Patil S, 2006, INT J STRESS MANAGE, V13, P460
   Ray U. S., 2001, Indian Journal of Physiology and Pharmacology, V45, P37
   Reardon M, 1996, PACE, V19, P1863, DOI 10.1111/j.1540-8159.1996.tb03241.x
   REISIN E, 1978, NEW ENGL J MED, V298, P1, DOI 10.1056/NEJM197801052980101
   Sahay B K, 2007, J Assoc Physicians India, V55, P121
   Selvamurthy W., 1998, Indian Journal of Physiology and Pharmacology, V42, P205
   SELVAMURTHY W, 1988, INT J BIOMETEOROL, V32, P188, DOI 10.1007/BF01045278
   Shimazu Tomokazu, 2005, Nihon Rinsho, V63, P973
   Singh S, 2008, INDIAN J CLIN BIOCHE, V23, P365, DOI 10.1007/s12291-008-0080-9
   Sinha S, 2007, J ALTERN COMPLEM MED, V13, P1085, DOI 10.1089/acm.2007.0567
   Smith C, 2007, COMPLEMENT THER MED, V15, P77, DOI 10.1016/j.ctim.2006.05.001
   Smith JA, 2011, ALTERN THER HEALTH M, V17, P22
   STAMLER R, 1978, JAMA-J AM MED ASSOC, V240, P1607, DOI 10.1001/jama.240.15.1607
   Steen B, 2001, Lakartidningen, V98, P1924
   Tapp LR, 2014, CLIN INTERV AGING, V9, P63, DOI 10.2147/CIA.S30048
   Terman A, 2006, ANN NY ACAD SCI, V1067, P27, DOI 10.1196/annals.1354.005
   Tulpule T H, 1971, Indian Heart J, V23, P259
   Viña J, 2007, IUBMB LIFE, V59, P249, DOI 10.1080/15216540601178067
   Woodworth R.S., 1971, Experimental Psychology
   Xiong GL, 2009, ANN NY ACAD SCI, V1172, P63, DOI 10.1196/annals.1393.002
   YONEZAWA Y, 1989, MECH AGEING DEV, V47, P65, DOI 10.1016/0047-6374(89)90008-0
   Yurtkuran M, 2007, COMPLEMENT THER MED, V15, P164, DOI 10.1016/j.ctim.2006.06.008
   Zhang J, 2007, J MANIP PHYSIOL THER, V30, P374, DOI 10.1016/j.jmpt.2007.04.001
NR 70
TC 67
Z9 74
U1 0
U2 48
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0161-9152
EI 1574-4647
J9 AGE
JI Age
PD AUG
PY 2014
VL 36
IS 4
AR 9683
DI 10.1007/s11357-014-9683-7
PG 17
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA AR8BR
UT WOS:000343801100020
PM 25012275
OA Green Published
DA 2025-06-11
ER

PT J
AU Khademi, R
   Mirzaei, A
   Mirzaei, A
   Edjlali, FR
   Askari, VR
   Rahimi, VB
AF Khademi, Reza
   Mirzaei, Ali
   Mirzaei, Amirhossein
   Edjlali, Farid Reza
   Askari, Vahid Reza
   Rahimi, Vafa Baradaran
TI Morin, as a natural flavonoid, provides promising influences against
   cardiovascular diseases
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Review
DE Morin; Cardiovascular; Heart; Inflammation; Antioxidant
ID OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; MYOCARDIAL-INFARCTION; RATS;
   ANTIOXIDANT; CELLS; HEART; DOXORUBICIN; EXPRESSION; HYDRATE
AB The present investigation evaluated the potential impacts of morin, a natural flavonoid, against cardiovascular disorders. Since inception until September 2024, PubMed, Scopus, and Web of Science have been searched extensively. The process involved eliminating duplicate entries and conducting a systematic review of the remaining studies post-full-text screening. The search was conducted with meticulousness and in adherence to established protocols. Morin has shown various cardioprotective effects in experimental models. It reduces oxidative stress, inflammation, and tissue damage in conditions like myocardial ischemia, injury, and infarction. It also mitigates the harmful effects of toxins and improves hemodynamic parameters, antioxidant levels, and cardiac function. Moreover, it can address conditions like chronic iron overload and metabolic syndrome. Its mechanisms of action involve regulating signaling pathways, promoting autophagy, and reducing oxidative stress and inflammation. Morin hydrate is promising as a therapeutic agent for cardiovascular and related disorders. Morin Hydrate exhibits promising cardioprotective properties, effectively reducing oxidative stress and inflammation in myocardial conditions while also countering the effects of toxins and improving heart function. Additionally, it holds the potential for addressing chronic iron overload and metabolic syndrome. Its multifaceted mechanisms, including signaling pathway regulation and promotion of autophagy, highlight its therapeutic potential for various cardiovascular and related disorders.
C1 [Khademi, Reza; Mirzaei, Ali; Mirzaei, Amirhossein] Mashhad Univ Med Sci, Student Res Comm, Fac Med, Mashhad, Iran.
   [Khademi, Reza; Mirzaei, Ali; Mirzaei, Amirhossein; Edjlali, Farid Reza; Rahimi, Vafa Baradaran] Mashhad Univ Med Sci, Fac Med, Dept Cardiovasc Dis, Mashhad, Iran.
   [Askari, Vahid Reza] Mashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Rahimi, VB (corresponding author), Mashhad Univ Med Sci, Fac Med, Dept Cardiovasc Dis, Mashhad, Iran.
EM Rezakhademi2001@gmail.com; Alimirzaei8001@gmail.com;
   mirzaeiah1998@gmail.com; fr.edjlali@gmail.com;
   vahidrezaaskary@gmail.com; baradaranrv@mums.ac.ir
RI Baradaran Rahimi, Vafa/AAR-4523-2021; Khademi, Reza/HTP-8711-2023;
   Askari, Vahid Reza/ABB-8991-2020
OI Khademi, Reza/0009-0001-5857-8003
FU Mashhad University of Medical Sciences, Mashhad, Iran
FX The research was supported by Mashhad University of Medical Sciences,
   Mashhad, Iran.
CR Aggul AG, 2020, CLIN EXP HEALTH SCI, V10, P228, DOI 10.33808/clinexphealthsci.632320
   Akhlaghipour I, 2024, PHYTOTHER RES, V38, P3973, DOI 10.1002/ptr.8261
   Al Numair KS, 2012, REDOX REP, V17, P20, DOI 10.1179/1351000211Y.0000000019
   Al-Numair KS, 2014, PROG NUTR, V16, P25
   Al-Numair KS, 2014, AFR J TRADIT COMPLEM, V11, P14, DOI 10.4314/ajtcam.v11i3.3
   Al-Numair KS, 2012, J NAT MED-TOKYO, V66, P95, DOI 10.1007/s11418-011-0558-2
   Aloud AA, 2019, PROG NUTR, V21, P793, DOI 10.23751/pn.v21i4.7721
   Bartfay WJ, 2000, J TRACE ELEM EXP MED, V13, P285, DOI 10.1002/1520-670X(2000)13:3<285::AID-JTRA6>3.0.CO;2-Z
   Behera SS, 2015, CURR PHARM DESIGN, V21, P4479, DOI 10.2174/1381612821666150817104635
   Capewell S, 2010, B WORLD HEALTH ORGAN, V88, P120, DOI 10.2471/BLT.08.057885
   Caselli A, 2016, CURR MED CHEM, V23, P774, DOI 10.2174/0929867323666160106150821
   Celermajer DS, 2012, J AM COLL CARDIOL, V60, P1207, DOI 10.1016/j.jacc.2012.03.074
   Dunbar SB, 2018, CIRCULATION, V137, pE558, DOI 10.1161/CIR.0000000000000570
   Fang SH, 2003, LIFE SCI, V74, P743, DOI 10.1016/j.lfs.2003.07.017
   Gong G, 2020, BIOMED PHARMACOTHER, V128, DOI 10.1016/j.biopha.2020.110301
   Hassan NF., 2019, INT J RES PHARM SCI, V10, P331
   Heeba GH, 2021, KOREAN J PHYSIOL PHA, V25, P177, DOI 10.4196/kjpp.2021.25.3.177
   Hsia CW, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19082386
   James AS, 2023, INFLAMMATION, V46, P175, DOI 10.1007/s10753-022-01720-2
   Kang DG, 2004, BIOL PHARM BULL, V27, P1779, DOI 10.1248/bpb.27.1779
   Kok LDS, 2000, LIFE SCI, V67, P91, DOI 10.1016/S0024-3205(00)00605-6
   Kuruvilla A., 2002, Indian Journal of Experimental Biology, V40, P7
   Kuzu M, 2018, BIOMED PHARMACOTHER, V106, P443, DOI 10.1016/j.biopha.2018.06.161
   Lee MH, 2017, INT J MOL MED, V39, P672, DOI 10.3892/ijmm.2017.2871
   Lian TW, 2008, BBA-MOL CELL BIOL L, V1781, P601, DOI 10.1016/j.bbalip.2008.06.009
   Liu S, 2018, INT J MOL MED, V42, P1379, DOI 10.3892/ijmm.2018.3743
   López-Tenorio II, 2020, FOOD RES INT, V137, DOI 10.1016/j.foodres.2020.109706
   Madkhali HA, 2020, SAUDI PHARM J, V28, P300, DOI 10.1016/j.jsps.2020.01.009
   Meng QY, 2021, INT IMMUNOPHARMACOL, V100, DOI 10.1016/j.intimp.2021.108096
   Nam GS, 2019, EUR J PHARMACOL, V865, DOI 10.1016/j.ejphar.2019.172734
   Parabathina RK., 2011, INT J PHARM PHARM SC, V3, P280
   Pogula BK, 2012, J PHYSIOL BIOCHEM, V68, P433, DOI 10.1007/s13105-012-0157-z
   Prahalathan P., 2012, Asian Pacific Journal of Tropical Biomedicine, V2, P443, DOI 10.1016/S2221-1691(12)60073-2
   Rahimi VB, 2022, BIOFACTORS, V48, P857, DOI 10.1002/biof.1869
   Rahmanian-Devin P, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/5945101
   Rameshrad M, 2021, LIFE SCI, V264, DOI 10.1016/j.lfs.2020.118659
   Rauf A, 2019, BIOMED PHARMACOTHER, V116, DOI 10.1016/j.biopha.2019.108999
   Shad AN, 2024, ARCH PHARM, V357, DOI 10.1002/ardp.202400240
   Shin SS, 2018, GEN PHYSIOL BIOPHYS, V37, P633, DOI 10.4149/gpb_2018028
   Shirazinia R, 2019, J PHARMACOPUNCT, V22, P16, DOI 10.3831/KPI.2019.22.002
   Taguchi K, 2020, BIOMED PHARMACOTHER, V129, DOI 10.1016/j.biopha.2020.110463
   Taguchi K, 2016, MOL NUTR FOOD RES, V60, P580, DOI 10.1002/mnfr.201500618
   Verma VK, 2024, LAB ANIM RES, V40, DOI 10.1186/s42826-024-00190-x
   Verma VK, 2020, PHARMACOL REP, V72, P877, DOI 10.1007/s43440-019-00011-2
   Verma VK, 2019, MOL BIOL REP, V46, P1139, DOI 10.1007/s11033-018-04575-9
   WU TW, 1994, BIOCHEM PHARMACOL, V47, P1099, DOI 10.1016/0006-2952(94)90424-3
   WU TW, 1995, BIOCHEM PHARMACOL, V49, P537, DOI 10.1016/0006-2952(94)00446-S
   Wu TW., 1996, LIFE SCI, V58, P17
   Yu J, 2022, INFLAMMATION, V45, P2406, DOI 10.1007/s10753-022-01701-5
   Zhang AN, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/2187306
   Zhang XD, 2019, CLIN EXP PHARMACOL P, V46, P1053, DOI 10.1111/1440-1681.13160
   Zhou Y, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600966
NR 52
TC 1
Z9 1
U1 4
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD JUN
PY 2025
VL 398
IS 6
BP 6293
EP 6310
DI 10.1007/s00210-024-03783-4
EA JAN 2025
PG 18
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 3FS1V
UT WOS:001396955400001
PM 39808314
DA 2025-06-11
ER

PT J
AU Taki, AG
   Mohammed, SA
   Allwsh, TA
AF Taki, Anmar Ghanem
   Mohammed, Shaha Abdallha
   Allwsh, Thikra Ali
TI ASPROSIN: RELATION TO OXIDATIVE STRESS FOR METABOLIC SYNDROME PATIENTS
   IN MOSUL/IRAQ
SO PERIODICO TCHE QUIMICA
LA English
DT Article
DE Asprosin Hormone; Oxidative Stress; Metabolic Syndrome; Insulin
   Resistance; total antioxidant capacity
AB Background: Asprosin is a protein hormone important in regulating appetite; glucose and lipid metabolites are secreted during fasting. Aims: The present study investigates the relationship between asprosin level and oxidative stress in MetS. Methods: The study included 171 participants persons aged 35-65 years who were divided into two groups: a control group, which included 75 participants, and a patient group, which included 95 participants from patients getting treatment at the Ibn Sina Educational Hospital in the Iraqi city of Mosul. Ethical approval was obtained from the Iraqi Ministry of Health- Nineveh Health. Five milliliters of venous blood were taken following a fast for an entire night. To perform oxidative and antioxidative factor tests as well as clinical evaluations. Results: Asprosin hormone levels in MetS significantly increased, but a significant decrease of antioxidative (glutathione, total antioxidant capacity, and arylesterase) also A substantial rise in malondialdehyde, lactoperoxidase, and peroxidase. It was found through the linear correlation coefficient (R) that there was a significant positive correlation between asprosin and oxidative and an inverse correlation with antioxidative variables. Discussion: These findings imply that asprosin is an indicator of metabolic disorders and is associated with MetS and oxidative stress indicators. Conclusions: Therefore, it can be considered a new indicator and a promising tool for diagnosis and treatment to initiate and develop.
C1 [Taki, Anmar Ghanem] Al Noor Univ Coll, Dept Radiol & Sonar Tech, Mosul, Iraq.
   [Mohammed, Shaha Abdallha] Ibn Sina Teaching Hosp, Biochem Lab, Mosul, Iraq.
   [Allwsh, Thikra Ali] Univ Mosul, Dept Chem, Collage Sci, Mosul, Iraq.
C3 Alnoor University; University of Mosul
RP Allwsh, TA (corresponding author), Univ Mosul, Dept Chem, Collage Sci, Mosul, Iraq.
EM thekraaliallwsh@uomosul.edu.iq
RI Allwsh, Thikra/ISA-6950-2023
CR Abdallha Mohammed S., 2023, MMSL, V92, P376, DOI [10.31482/mmsl.2023.008, DOI 10.31482/MMSL.2023.008]
   Acara AC, 2018, AM J EMERG MED, V36, P1504, DOI 10.1016/j.ajem.2017.12.032
   Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Allwsh T.A., 2013, Rafidain Journal of Science, V24, P64
   Bajic VP, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/5028181
   Brunström M, 2016, BMJ-BRIT MED J, V352, DOI 10.1136/bmj.i717
   Catharina AS, 2018, ARQ BRAS CARDIOL, V110, P514, DOI 10.5935/abc.20180076
   Colak E, 2021, J MED BIOCHEM, V40, P1, DOI 10.5937/jomb0-24652
   Duerrschmid C, 2017, NAT MED, V23, P1444, DOI 10.1038/nm.4432
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Haque T, 2019, DIABETOL METAB SYNDR, V11, DOI 10.1186/s13098-019-0446-6
   Jasim R.F., 2008, Rafidain Journal of Science, V19, P157
   Jasim Rana F., 2021, Iraqi Journal of Veterinary Sciences, V35, P451, DOI 10.33899/ijvs.2020.127001.1429
   Jasim RF, 2021, EGYPT J CHEM, V64, P6991, DOI 10.21608/EJCHEM.2021.80062.3947
   Jung TW, 2019, J CELL PHYSIOL, V234, P20888, DOI 10.1002/jcp.28694
   Magacz M, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20061443
   Masenga SK, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24097898
   Munteanu IG, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22073380
   Newsholme P, 2019, AM J PHYSIOL-CELL PH, V317, pC420, DOI 10.1152/ajpcell.00141.2019
   Quon M J, 1994, Diabetes Res, V25, P139
   Ravi Kiran S.B., 2016, International Journal of Pharmaceutical Sciences Review and Research, V40, P271
   Rezzani R, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020301
   Romere C, 2016, CELL, V165, P566, DOI 10.1016/j.cell.2016.02.063
   Ross R, 2020, NAT REV ENDOCRINOL, V16, P177, DOI 10.1038/s41574-019-0310-7
   Sabah S., 2020, International Journal of Pharmaceutical Research, V12, P351, DOI [10.31838/ijpr/2020.12.04.351, DOI 10.31838/IJPR/2020.12.04.351]
   Sankhla M, 2012, CLIN LAB, V58, P385
   Sebeková K, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12061221
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Vona R, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8267234
   Wang K, 2018, INT J ENDOCRINOL, V2018, DOI 10.1155/2018/9376179
   Wang SJ, 2021, CARDIOVASC DIABETOL, V20, DOI 10.1186/s12933-021-01274-x
   Yasein N., 2010, Eastern Mediterranean Health Journal, V16, P375
   Yuan MY, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00064
   Zhang XY, 2020, J DIABETES INVEST, V11, P349, DOI 10.1111/jdi.13148
NR 35
TC 0
Z9 0
U1 1
U2 1
PU TCHE QUIMICA GROUP
PI PORTO ALEGRE RS
PA 359 ANITA GARIBALDI ST, RM 603, PORTO ALEGRE RS, 90450-001, BRAZIL
SN 1806-0374
EI 2179-0302
J9 PERIOD TCHE QUIM
JI Period. Tche Quim.
PY 2024
VL 21
IS 48
DI 10.52571/PTQ.v21.n48.2024_11_TAKI_pgs_132_139.pdf
PG 180
WC Chemistry, Multidisciplinary
WE Emerging Sources Citation Index (ESCI)
SC Chemistry
GA O6A7D
UT WOS:001371935900011
OA Bronze
DA 2025-06-11
ER

PT J
AU Terzo, S
   Mulé, F
   Amato, A
AF Terzo, Simona
   Mule, Flavia
   Amato, Antonella
TI Honey and obesity-related dysfunctions: a summary on health benefits
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Review
DE Honey; Polyphenols; Obesity; Oxidative stress; Neurodegeneration;
   Hypertension
ID HIGH-FAT DIET; IMPROVES MEMORY PERFORMANCE; NATURAL HONEY; OXIDATIVE
   STRESS; TUALANG HONEY; ANTIOXIDANT ACTIVITY; GLYCEMIC CONTROL;
   ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; METABOLIC SYNDROME
AB Honey is a natural product, containing flavonoids and phenolic acids, appreciated for its therapeutic abilities since ancient times. Although the bioactive potential is linked to the composition, that is variable depending on mainly the botanical origin, honey has antioxidant and anti-inflammatory properties. Therefore, honey, administered alone or in combination with conventional therapy, might result useful in the management of chronic diseases that are commonly associated with oxidative stress and inflammation state. Obesity is a metabolic disorder characterized by visceral adiposity. The adipose tissue becomes hypertrophic and undergoes hyperplasia, resulting in a hypoxic environment, oxidative stress and production of pro-inflammatory mediators that can be responsible for other disorders, such as metabolic syndrome and neurodegeneration. Experimental evidence from animals have shown that honey improves glycemic control and lipid profile with consequent protection from endothelial dysfunction and neurodegeneration. The purpose of the present review is to summarize the current literature concerning the beneficial effects of honey in the management of the obesity-related dysfunctions, including neurodegeneration. Based on the key constituents of honey, the paper also highlights polyphenols to be potentially responsible for the health benefits of honey. Further well-designed and controlled studies are necessary to validate these benefits in humans. (C) 2020 Elsevier Inc. All rights reserved.
C1 [Terzo, Simona; Mule, Flavia; Amato, Antonella] Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol, Palermo, Italy.
   [Terzo, Simona] Univ Palermo, Dept Neurosci & Cell Biol, Palermo, Italy.
C3 University of Palermo; University of Palermo
RP Amato, A (corresponding author), Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol, Palermo, Italy.
EM simona.terzo01@unipa.it; flavia.mule@unipa.it; antonella.amato@unipa.it
RI Mulè, Flavia/AAX-7921-2020; Amato, Antonella/AAX-8821-2020
CR Ab Wahab SZ, 2018, COMPLEMENT THER MED, V41, P154, DOI 10.1016/j.ctim.2018.08.015
   Abdulmajeed WI, 2016, METAB BRAIN DIS, V31, P37, DOI 10.1007/s11011-015-9733-6
   Abdulrhman M, 2011, ACTA DIABETOL, V48, P89, DOI 10.1007/s00592-009-0167-7
   Abdulrhman MM, 2013, J MED FOOD, V16, P66, DOI 10.1089/jmf.2012.0108
   Ahmad A, 2008, J FOOD SCI, V73, pH165, DOI 10.1111/j.1750-3841.2008.00887.x
   Ahmad NS, 2017, J ALTERN COMPLEM MED, V23, P989, DOI 10.1089/acm.2017.0129
   Akanmu MA, 2011, AFR J TRADIT COMPLEM, V8, P230
   Al Aamri ZM, 2017, J DIABETES METAB DIS, V16, DOI 10.1186/s40200-016-0278-y
   Al-Rahbi B, 2014, ACTA HISTOCHEM, V116, P79, DOI 10.1016/j.acthis.2013.05.004
   Al-Waili N, 2003, EUR J MED RES, V8, P295
   Al-Waili N, 2012, SCI WORLD J, DOI 10.1100/2012/930849
   Al-Waili NS, 2004, J MED FOOD, V7, P100, DOI 10.1089/109662004322984789
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Ali Amira Mohammed, 2019, Neuropsychopharmacology Reports, V39, P312, DOI 10.1002/npr2.12079
   Almasaudi SB, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/5413917
   Alvarez-Suarez JM, 2014, FOODS, V3, P420, DOI 10.3390/foods3030420
   Alvarez-Suarez JM, 2013, CURR MED CHEM, V20, P621, DOI 10.2174/092986713804999358
   [Anonymous], ALZHEIMERS DEMENT
   [Anonymous], IEEE COMMUN LETT
   Appeldoorn MM, 2009, J AGR FOOD CHEM, V57, P7693, DOI 10.1021/jf901381x
   Arshad NA, 2019, MED HEALTH-KUALA LUM, V14, P30, DOI 10.17576/MH.2019.1402.03
   Atayoglu AT, 2016, TURK J MED SCI, V46, P483, DOI 10.3906/sag-1502-102
   Attanzio A, 2016, HELIYON, V2, DOI 10.1016/j.heliyon.2016.e00193
   Aziz MSA, 2017, BIOMED PHARMACOTHER, V89, P135, DOI 10.1016/j.biopha.2017.02.026
   Azman KF, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/1549158
   Azman KF, 2015, NOISE HEALTH, V17, P83, DOI 10.4103/1463-1741.153388
   Bahrami M, 2009, INT J FOOD SCI NUTR, V60, P618, DOI 10.3109/09637480801990389
   Bobis O, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/4757893
   Busserolles J, 2002, J NUTR, V132, P3379, DOI 10.1093/jn/132.11.3379
   Cani PD, 2008, PATHOL BIOL, V56, P305, DOI 10.1016/j.patbio.2007.09.008
   Chepulis L, 2008, J FOOD SCI, V73, pH1, DOI 10.1111/j.1750-3841.2007.00592.x
   Chepulis LM, 2009, PHYSIOL BEHAV, V97, P359, DOI 10.1016/j.physbeh.2009.03.001
   Cianciosi D, 2018, MOLECULES, V23, DOI 10.3390/molecules23092322
   Cogolludo A, 2007, CARDIOVASC RES, V73, P424, DOI 10.1016/j.cardiores.2006.09.008
   Combarros-Fuertes P, 2019, J AGR FOOD CHEM, V67, P688, DOI 10.1021/acs.jafc.8b05436
   Deibert P, 2010, EUR J CLIN NUTR, V64, P762, DOI 10.1038/ejcn.2009.103
   Duffy CM, 2019, NEUROBIOL LEARN MEM, V157, P41, DOI 10.1016/j.nlm.2018.11.008
   Dzugan M, 2018, MOLECULES, V23, DOI 10.3390/molecules23082069
   Ecelbarger CM, 2016, AM J PHYSIOL-RENAL, V310, pF1175, DOI 10.1152/ajprenal.00095.2016
   Erejuwa O O, 2018, Niger J Physiol Sci, V33, P129
   Erejuwa OO, 2010, ANN ENDOCRINOL-PARIS, V71, P291, DOI 10.1016/j.ando.2010.03.003
   Erejuwa OO, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030095
   Erejuwa OO, 2014, J DIABETES METAB DIS, V13, DOI 10.1186/2251-6581-13-23
   Erejuwa OO, 2011, INT J BIOL SCI, V7, P244, DOI 10.7150/ijbs.7.244
   Farakla I, 2019, EUR J CLIN INVEST, V49, DOI 10.1111/eci.13042
   Gasic U, 2014, FOOD CHEM, V145, P599, DOI 10.1016/j.foodchem.2013.08.088
   Gasparrini M, 2018, FOOD CHEM TOXICOL, V120, P578, DOI 10.1016/j.fct.2018.08.001
   Gourdomichali T, 2018, EUR J CLIN NUTR, V72, P1709, DOI 10.1038/s41430-018-0160-8
   Hamad R, 2015, CLIN EXP PHARMACOL P, V42, P843, DOI 10.1111/1440-1681.12433
   Heneka MT, 2015, LANCET NEUROL, V14, P388, DOI 10.1016/S1474-4422(15)70016-5
   Imtara H, 2018, VET WORLD, V11, P1491, DOI 10.14202/vetworld.2018.1491-1499
   Jurca u R., 2017, Palest. Third Millenn. Civ. Sport, V18, P201
   Kalantari N, 2016, CYTOKINE, V88, P85, DOI 10.1016/j.cyto.2016.08.029
   Kempuraj D., 2016, J NEUROLOGY NEUROSUR, V1, P1
   Khalil MI, 2011, J FOOD SCI, V76, pC921, DOI 10.1111/j.1750-3841.2011.02282.x
   Khalil MI, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/286051
   Kilicoglu B, 2008, AM J SURG, V195, P249, DOI 10.1016/j.amjsurg.2007.04.011
   Kim TH, 2012, INFLAMM RES, V61, P217, DOI 10.1007/s00011-011-0403-9
   Kleemann R, 2011, ATHEROSCLEROSIS, V218, P44, DOI 10.1016/j.atherosclerosis.2011.04.023
   Kotanidou A, 2002, AM J RESP CRIT CARE, V165, P818, DOI 10.1164/ajrccm.165.6.2101049
   Krishnasree V, 2017, INDIAN J TRADIT KNOW, V16, P134
   Kroner Z, 2009, ALTERN MED REV, V14, P373
   Kuhlmann CRW, 2005, PLANTA MED, V71, P520, DOI 10.1055/s-2005-864152
   Lori G, 2019, BIOMED PHARMACOTHER, V113, DOI 10.1016/j.biopha.2019.108752
   Manna P, 2015, METAB SYNDR RELAT D, V13, P423, DOI 10.1089/met.2015.0095
   Mannina L, 2015, J AGR FOOD CHEM, V63, P5864, DOI 10.1021/jf506192s
   Mato I, 2006, J AGR FOOD CHEM, V54, P1541, DOI 10.1021/jf051757i
   Mehta J, 2018, ANTIOXIDANTS-BASEL, V7, DOI 10.3390/antiox7100147
   Meo SA, 2017, SAUDI J BIOL SCI, V24, P975, DOI 10.1016/j.sjbs.2016.12.010
   Miguel MG, 2017, INTEGR MED INSIGHTS, V12, DOI 10.1177/1178633717702869
   Minden-Birkenmaier BA, 2019, INT J BIOMATER, V2019, DOI 10.1155/2019/6132581
   Mohammadimanesh Ali, 2019, Arch Med Sci Atheroscler Dis, V4, pe113, DOI 10.5114/amsad.2019.85409
   Nasrolahi O, 2012, AVICENNA J PHYTOMEDI, V2, P212
   Nuzzo D, 2019, NEUROBIOL DIS, V121, P296, DOI 10.1016/j.nbd.2018.10.012
   Nuzzo D, 2015, CURR ALZHEIMER RES, V12, P723, DOI 10.2174/1567205012666150710115506
   Omotayo EO, 2010, INT J VITAM NUTR RES, V80, P74, DOI 10.1024/0300-9831/a000008
   Othman Zahiruddin, 2015, Med Sci (Basel), V3, P3, DOI 10.3390/medsci3020003
   Othman Z, 2011, MENOPAUSE, V18, P1219, DOI 10.1097/gme.0b013e31821e2044
   Owoyele BV, 2014, METAB BRAIN DIS, V29, P167, DOI 10.1007/s11011-013-9458-3
   Perna A, 2013, INT J FOOD SCI TECH, V48, P1899, DOI 10.1111/ijfs.12169
   Pugazhenthi S, 2017, BBA-MOL BASIS DIS, V1863, P1037, DOI 10.1016/j.bbadis.2016.04.017
   Rahmouni K, 2010, CURR HYPERTENS REV, V6, P104, DOI 10.2174/157340210791170994
   Ramli NZ, 2018, NUTRIENTS, V10, DOI 10.3390/nu10081009
   Ranneh Y, 2019, NUTR METAB, V16, DOI 10.1186/s12986-019-0341-z
   Rasad H, 2018, CLIN NUTR ESPEN, V26, P8, DOI 10.1016/j.clnesp.2018.04.016
   Safi SZ, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/5843615
   Sah SK, 2017, BIOCHEM BIOPH RES CO, V493, P731, DOI 10.1016/j.bbrc.2017.08.122
   Saibandith B, 2017, MOLECULES, V22, DOI 10.3390/molecules22071082
   Sairazi NSM, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/7287820
   Sairazi NSM, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-016-1534-x
   Saltiel AR, 2017, J CLIN INVEST, V127, P1, DOI [10.1172/JCI92035, 10.1172/jci92035]
   Samanta A, 1985, Diabet Med, V2, P371
   Samarghandian S, 2017, PHARMACOGN RES, V9, P121, DOI 10.4103/0974-8490.204647
   Samat S, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/1342150
   Sánchez M, 2006, J HYPERTENS, V24, P75, DOI 10.1097/01.hjh.0000198029.22472.d9
   Sánchez-Tapia M, 2019, NUTRIENTS, V11, DOI 10.3390/nu11040880
   Schramm DD, 2003, J AGR FOOD CHEM, V51, P1732, DOI 10.1021/jf025928k
   Schulz E, 2011, HYPERTENS RES, V34, P665, DOI 10.1038/hr.2011.39
   Shapla UM, 2018, CHEM CENT J, V12, DOI 10.1186/s13065-018-0408-3
   Shen Y, 2012, BIOCHEM PHARMACOL, V84, P1036, DOI 10.1016/j.bcp.2012.07.016
   Spencer SJ, 2017, NEUROBIOL AGING, V58, P88, DOI 10.1016/j.neurobiolaging.2017.06.014
   Syarifah-Noratiqah SB, 2018, CURR DRUG TARGETS, V19, P927, DOI 10.2174/1389450118666170328122527
   Tappy L, 2018, J EXP BIOL, V221, DOI 10.1242/jeb.164202
   Tartibian B, 2012, CLIN J SPORT MED, V22, P132, DOI 10.1097/JSM.0b013e31823f310a
   Tomblin V, 2014, INT J GEN MED, V7, P149, DOI 10.2147/IJGM.S45839
   Vollenweider P, 2015, HANDB EXP PHARMACOL, V224, P405, DOI 10.1007/978-3-319-09665-0_12
   Whitfield P, 2016, EUR J NUTR, V55, P1123, DOI 10.1007/s00394-015-0926-x
   Whitmer RA, 2005, BMJ-BRIT MED J, V330, P1360, DOI 10.1136/bmj.38446.466238.E0
   Woo KJ, 2005, FEBS LETT, V579, P705, DOI 10.1016/j.febslet.2004.12.048
   Xiao J, 2016, EUR J NUTR, V55, P1465, DOI 10.1007/s00394-015-0964-4
   Yaghoobi N, 2008, THESCIENTIFICWORLDJO, V8, P463, DOI 10.1100/tsw.2008.64
   Zhao HA, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201900638
NR 112
TC 34
Z9 37
U1 6
U2 46
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD AUG
PY 2020
VL 82
AR 108401
DI 10.1016/j.jnutbio.2020.108401
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA LY2SU
UT WOS:000540374200005
PM 32454412
DA 2025-06-11
ER

PT J
AU González-Montoya, M
   Vargas-Vargas, MA
   Torres-Isidro, O
   García-Berumen, CI
   Cuiniche-Méndez, MG
   Saavedra-Molina, A
   Ontiveros-Rodríguez, JC
   Garcia-Gutiérrez, HA
   Calderon-Cortés, E
   Cortés-Rojo, C
AF Gonzalez-Montoya, Marcela
   Vargas-Vargas, Manuel Alejandro
   Torres-Isidro, Olin
   Garcia-Berumen, Claudia Isabel
   Cuiniche-Mendez, Maria Guadalupe
   Saavedra-Molina, Alfredo
   Ontiveros-Rodriguez, Julio Cesar
   Garcia-Gutierrez, Hugo A.
   Calderon-Cortes, Elizabeth
   Cortes-Rojo, Christian
TI Evaluation of Unsaponifiable Fraction of Avocado Oil on Liver and Kidney
   Mitochondrial Function in Rats Fed a High-Fat and High-Carbohydrate Diet
SO METABOLITES
LA English
DT Article
DE avocado oil; unsaponifiable fraction; high-fat diet; high-carbohydrate
   diet; metabolic syndrome; mitochondria
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; DYSFUNCTION; MODEL
AB High-fat and high-carbohydrate (HF-HC) diets induce metabolic syndrome via mitochondrial dysfunction and oxidative stress. We have previously shown that this may be prevented by avocado oil, a source of bioactive molecules with antioxidant properties. However, it is unknown if these effects are mediated by the unsaponifiable fraction of avocado oil (UFAO). Thus, we tested if this fraction improves glucose metabolism, bioenergetics and oxidative stress in mitochondria from the kidney and liver of rats fed an HF-HC diet. We found that 12 weeks of an HF-HC diet impaired glucose utilization and increased insulin resistance, which was prevented by UFAO administration. The HF-HC diet decreased respiration, membrane potential and electron transport chain (ETC) function in liver and kidney mitochondria. These mitochondrial dysfunctions were prevented by UFAO intake. Unexpectedly, UFAO increased ROS levels in the mitochondria of control animals and did not decrease them in rats with an HF-HC diet; however, UFAO protects liver and kidney mitochondria from iron-induced oxidative stress. These findings suggest that impairments in glucose metabolism and mitochondrial function by an HF-HC diet may be prevented by UFAO, without decreasing ROS generation but protecting mitochondria from oxidative damage.
C1 [Gonzalez-Montoya, Marcela; Vargas-Vargas, Manuel Alejandro; Torres-Isidro, Olin; Garcia-Berumen, Claudia Isabel; Cuiniche-Mendez, Maria Guadalupe; Saavedra-Molina, Alfredo; Garcia-Gutierrez, Hugo A.; Cortes-Rojo, Christian] Univ Michoacana, Inst Invest Quim Biol, Morelia 58030, MC, Mexico.
   [Ontiveros-Rodriguez, Julio Cesar] Univ Michoacana, Consejo Nacl Human Ciencias & Tecnol, Inst Invest Quim Biol, Morelia 58030, MC, Mexico.
   [Calderon-Cortes, Elizabeth] Univ Michoacana, Fac Enfermeria, Morelia 58020, MC, Mexico.
C3 Universidad Michoacana de San Nicolas de Hidalgo; Universidad Michoacana
   de San Nicolas de Hidalgo; Universidad Michoacana de San Nicolas de
   Hidalgo
RP González-Montoya, M; Cortés-Rojo, C (corresponding author), Univ Michoacana, Inst Invest Quim Biol, Morelia 58030, MC, Mexico.
EM marceglezmon@gmail.com; 1371614e@umich.mx; 1584209e@umich.mx;
   0620929h@umich.mx; 1900220g@umich.mx; francisco.saavedra@umich.mx;
   julio.ontiveros@umich.mx; hgarcia@umich.mx; elizabeth.calderon@umich.mx;
   christian.cortes@umich.mx
RI García, Hugo/AAE-6351-2020; Cortes, Christian./ABF-4312-2021
OI Garcia-Gutierrez, Hugo A./0000-0003-2841-0135; GONZALEZ MONTOYA,
   MARCELA/0000-0001-9604-5622; Vargas Vargas, Manuel
   Alejandro/0000-0003-3239-123X; Cortes-Rojo,
   Christian/0000-0002-4850-772X; Saavedra-Molina,
   Alfredo/0000-0002-0811-2950; TORRES ISIDRO, OLIN/0009-0004-8813-5619
FU Instituto de Ciencia, Tecnologia e Innovacion-Gobierno del Estado de
   Michoacan [ICTI-PICIR23-063, ICTI PICIR23-028]; Programa Proyectos de
   Investigacion financiados 2024, Coordinacion de Investigacion
   Cientifica, Universidad Michoacana de San Nicolas de Hidalgo, Mexico
   [7973911]; Estancias Posdoctorales por Mexico [472544, 589763]; Consejo
   Nacional de Humanidades, Ciencia y Tecnologia (CONAHCYT)
FX This research was supported by Instituto de Ciencia, Tecnologia e
   Innovacion-Gobierno del Estado de Michoacan, No. ICTI-PICIR23-063 and
   No. ICTI PICIR23-028; and Programa Proyectos de Investigacion
   financiados 2024, Coordinacion de Investigacion Cientifica, Universidad
   Michoacana de San Nicolas de Hidalgo (7973911), Mexico. Estancias
   Posdoctorales por Mexico 2022 (472544) and 2023 (589763), Consejo
   Nacional de Humanidades, Ciencia y Tecnologia (CONAHCYT).
CR Márquez-Ramírez CA, 2021, LIFE-BASEL, V11, DOI 10.3390/life11111122
   [Anonymous], When to Worry If Weight Falls Off without Trying
   Antunes LC, 2016, ARCH ENDOCRIN METAB, V60, P138, DOI 10.1590/2359-3997000000169
   Baky MH, 2021, ACS OMEGA, V6, P24788, DOI 10.1021/acsomega.1c03627
   Berasategi I, 2012, FOOD CHEM, V132, P439, DOI 10.1016/j.foodchem.2011.11.018
   Bramlage KS, 2021, J PEDIATR GASTR NUTR, V73, P99, DOI 10.1097/MPG.0000000000003068
   Brand MD, 2011, BIOCHEM J, V435, P297, DOI 10.1042/BJ20110162
   Casanova A, 2023, FRONT PHYSIOL, V14, DOI 10.3389/fphys.2023.1114231
   Cervantes-Paz B, 2021, COMPR REV FOOD SCI F, V20, P4120, DOI 10.1111/1541-4337.12784
   Chen SX, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.786599
   Choi D, 2020, MOLECULES, V25, DOI 10.3390/molecules25071554
   Clemente-Suárez VJ, 2023, NUTRIENTS, V15, DOI 10.3390/nu15122749
   Cortés-Rojo C, 2009, J BIOENERG BIOMEMBR, V41, P15, DOI 10.1007/s10863-009-9200-3
   Cuffaro D, 2023, NUTRIENTS, V15, DOI 10.3390/nu15234966
   D'Silva A., 2015, Asian Journal of Poultry Science, V9, P144, DOI 10.3923/ajpsaj.2015.144.154
   Dansethakul P, 2015, EXCLI J, V14, P478, DOI 10.17179/excli2015-162
   Davis RC, 2010, DIABETES, V59, P1616, DOI 10.2337/db09-0878
   Diaz-Vegas A, 2020, ENDOCR REV, V41, P491, DOI 10.1210/endrev/bnaa005
   Erdelmeier I, 1998, CHEM RES TOXICOL, V11, P1184, DOI 10.1021/tx970180z
   GORNALL AG, 1949, J BIOL CHEM, V177, P751
   Ho HJ, 2023, CELLS-BASEL, V12, DOI 10.3390/cells12010088
   Horne RG, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113557
   García-Berumen CI, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.1089130
   García-Berumen CI, 2019, LIPIDS HEALTH DIS, V18, DOI 10.1186/s12944-019-1024-5
   Krumreich FD, 2018, FOOD CHEM, V257, P376, DOI 10.1016/j.foodchem.2018.03.048
   Lane MM, 2024, BMJ-BRIT MED J, V384, DOI 10.1136/bmj-2023-077310
   Lee S, 2018, KOREAN J ANESTHESIOL, V71, P353, DOI 10.4097/kja.d.18.00242
   Leigh SJ, 2019, JOVE-J VIS EXP, DOI 10.3791/60262
   Márquez-Ramírez CA, 2018, NUTRITION, V54, P60, DOI 10.1016/j.nut.2018.02.024
   Miceli M, 2018, MOLECULES, V23, DOI 10.3390/molecules23040710
   Monteiro CA, 2019, PUBLIC HEALTH NUTR, V22, P936, DOI 10.1017/S1368980018003762
   Moreno-Fernández S, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101502
   Ortiz-Avila O, 2024, J BIOL REG HOMEOS AG, V38, P1975, DOI 10.23812/j.biol.regul.homeost.agents.20243803.154
   Ortiz-Avila O, 2017, J BIOENERG BIOMEMBR, V49, P205, DOI 10.1007/s10863-017-9697-9
   Ortiz-Avila O, 2015, J BIOENERG BIOMEMBR, V47, P337, DOI 10.1007/s10863-015-9614-z
   Ortiz-Avila O, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/485759
   Rosas-Villegas A, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040393
   Sakuma T, 2022, LAB INVEST, V102, P1150, DOI 10.1038/s41374-022-00807-6
   Salehi B, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10010130
   Sayuti NH, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12081552
   Sergi D, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00532
   Seruji NMU, 2013, J CHEM-NY, V2013, DOI 10.1155/2013/913406
   Shi SJ, 2021, TRANSPLANTATION, V105, P2362, DOI 10.1097/TP.0000000000003691
   Stinson EJ, 2018, OBESITY, V26, P689, DOI 10.1002/oby.22124
   Sun Y, 2020, CELL DEATH DIS, V11, DOI 10.1038/s41419-020-03122-4
   Thiruvengadam M, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10121859
   Touvier M, 2023, BMJ-BRIT MED J, V383, DOI 10.1136/bmj-2023-075294
   Veit M, 2022, EUR J CLIN NUTR, V76, P1497, DOI 10.1038/s41430-022-01114-5
   Wang X, 2023, J CARDIOVASC PHARM T, V28, DOI 10.1177/10742484231162249
   Yang SS, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000005618
   Yki-Järvinen H, 2005, ANN MED, V37, P347, DOI 10.1080/07853890510037383
   Young S, 2005, J CONTROL RELEASE, V109, P256, DOI 10.1016/j.jconrel.2005.09.023
   Younis IY, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-08479-4
   Yuan CX, 2019, LIPIDS HEALTH DIS, V18, DOI 10.1186/s12944-019-1096-2
   Zhao Y, 2022, NUTRIENTS, V14, DOI 10.3390/nu14112181
NR 55
TC 1
Z9 1
U1 3
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD AUG
PY 2024
VL 14
IS 8
AR 431
DI 10.3390/metabo14080431
PG 18
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA E8W4G
UT WOS:001305744700001
PM 39195527
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Liao, MT
   Sung, CC
   Hung, KC
   Wu, CC
   Lo, L
   Lu, KC
AF Liao, Min-Tser
   Sung, Chih-Chien
   Hung, Kuo-Chin
   Wu, Chia-Chao
   Lo, Lan
   Lu, Kuo-Cheng
TI Insulin Resistance in Patients with Chronic Kidney Disease
SO JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
LA English
DT Review
ID ENDOPLASMIC-RETICULUM STRESS; FETUIN-A LEVELS; DENSITY-LIPOPROTEIN
   CHOLESTEROL; METABOLIC RISK-FACTORS; VITAMIN-D; GLUCOSE-TOLERANCE;
   MAINTENANCE HEMODIALYSIS; CARDIOVASCULAR-DISEASE; SKELETAL-MUSCLE;
   ENDOTHELIAL DYSFUNCTION
AB Metabolic syndrome and its components are associated with chronic kidney disease (CKD) development. Insulin resistance (IR) plays a central role in the metabolic syndrome and is associated with increased risk for CKD in nondiabetic patients. IR is common in patients with mild-to-moderate stage CKD, even when the glomerular filtration rate is within the normal range. IR, along with oxidative stress and inflammation, also promotes kidney disease. In patients with end stage renal disease, IR is an independent predictor of cardiovascular disease and is linked to protein energy wasting and malnutrition. Systemic inflammation, oxidative stress, elevated serum adipokines and fetuin-A, metabolic acidosis, vitamin D deficiency, depressed serum erythropoietin, endoplasmic reticulum stress, and suppressors of cytokine signaling all cause IR by suppressing insulin receptor-PI3K-Akt pathways in CKD. In addition to adequate renal replacement therapy and correction of uremia-associated factors, thiazolidinedione, ghrelin, protein restriction, and keto-acid supplementation are therapeutic options. Weight control, reduced daily prednisolone dosage, and the use of cyclosporin decrease the risk of developing new-onset diabetes after kidney transplantation. Improved understanding of the pathogenic mechanisms underlying IR in CKD may lead to more effective therapeutic strategies to reduce uremia-associated morbidity and mortality.
C1 [Hung, Kuo-Chin; Lo, Lan; Lu, Kuo-Cheng] Fu Jen Catholic Univ, Cardinal Tien Hosp, Sch Med, Dept Med,Div Nephrol, New Taipei City 242, Taiwan.
   [Liao, Min-Tser] Taoyuan Armed Forces Gen Hosp, Dept Pediat, Tao Yuan 325, Taiwan.
   [Liao, Min-Tser] Triserv Gen Hosp, Natl Def Med Ctr, Dept Pediat, Taipei 114, Taiwan.
   [Sung, Chih-Chien] Triserv Gen Hosp, Natl Def Med Ctr, Dept Med, Div Nephrol, Taipei 114, Taiwan.
C3 Fu Jen Catholic University; Cardinal Tien Hospital; National Defense
   Medical Center; Tri-Service General Hospital; Tri-Service General
   Hospital; National Defense Medical Center
RP Lu, KC (corresponding author), Fu Jen Catholic Univ, Cardinal Tien Hosp, Sch Med, Dept Med,Div Nephrol, New Taipei City 242, Taiwan.
EM kuochenglu@gmail.com
RI Wu, Changzhi/D-6413-2017
FU Cardinal-Tien Hospital [CTH-99-1-2A06]; Teh-Tzer Study Group for Human
   Medical Research Foundation [B-99-10-53]
FX The Research Fund from Cardinal-Tien Hospital (CTH-99-1-2A06) and
   Teh-Tzer Study Group for Human Medical Research Foundation (B-99-10-53)
   supported this study.
CR Adamczak M, 2009, SEMIN DIALYSIS, V22, P391, DOI 10.1111/j.1525-139X.2009.00587.x
   Ahima RS, 2008, J CLIN INVEST, V118, P1619, DOI 10.1172/JCI35655
   AKMAL M, 1985, J CLIN INVEST, V75, P1037, DOI 10.1172/JCI111765
   AUBERGER P, 1989, CELL, V58, P631, DOI 10.1016/0092-8674(89)90098-6
   Axelsson J, 2006, KIDNEY INT, V69, P596, DOI 10.1038/sj.ki.5000089
   Bailey JL, 2006, J AM SOC NEPHROL, V17, P1388, DOI 10.1681/ASN.2004100842
   Barazzoni R, 2008, CLIN NUTR, V27, P142, DOI 10.1016/j.clnu.2007.06.013
   Barazzoni R, 2012, J RENAL NUTR, V22, P171, DOI 10.1053/j.jrn.2011.10.017
   Barazzoni R, 2010, KIDNEY INT, V77, P23, DOI 10.1038/ki.2009.411
   Baynes KCR, 1997, DIABETOLOGIA, V40, P344, DOI 10.1007/s001250050685
   Becker BN, 1997, J AM SOC NEPHROL, V8, P475
   Berg AH, 2001, NAT MED, V7, P947, DOI 10.1038/90992
   Bergrem HA, 2010, NEPHROL DIAL TRANSPL, V25, P985, DOI 10.1093/ndt/gfp566
   Brunelli SM, 2009, KIDNEY INT, V75, P961, DOI 10.1038/ki.2009.4
   CADE C, 1986, ENDOCRINOLOGY, V119, P84, DOI 10.1210/endo-119-1-84
   Caglar K, 2008, CLIN J AM SOC NEPHRO, V3, P61, DOI 10.2215/CJN.02810707
   Chadban S, 2008, NEPHROL DIAL TRANSPL, V23, P1816, DOI 10.1093/ndt/gfn052
   Chen J, 2007, NEPHROL DIAL TRANSPL, V22, P1100, DOI 10.1093/ndt/gfl759
   Chen Y, 2011, AM J PHYSIOL-ENDOC M, V301, pE873, DOI 10.1152/ajpendo.00068.2011
   Cheng HT, 2012, J CLIN ENDOCR METAB, V97, P1268, DOI 10.1210/jc.2011-2658
   Cheng MF, 2010, J BIOMED BIOTECHNOL, DOI 10.1155/2010/513853
   Cheung AK, 2000, KIDNEY INT, V58, P353, DOI 10.1046/j.1523-1755.2000.00173.x
   Cheung W, 2005, J CLIN INVEST, V115, P1659, DOI 10.1172/JCI22521
   Chiu KC, 2004, AM J CLIN NUTR, V79, P820
   Chiu YW, 2009, SEMIN NEPHROL, V29, P67, DOI 10.1016/j.semnephrol.2008.10.009
   Chonchol M, 2007, KIDNEY INT, V71, P134, DOI 10.1038/sj.ki.5002002
   CHURCH JM, 1988, METABOLISM, V37, P505, DOI 10.1016/0026-0495(88)90162-X
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cohen G, 2009, SEMIN DIALYSIS, V22, P373, DOI 10.1111/j.1525-139X.2009.00583.x
   Cybulsky AV, 2010, KIDNEY INT, V77, P187, DOI 10.1038/ki.2009.389
   D'Apolito M, 2010, J CLIN INVEST, V120, P203, DOI 10.1172/JCI37672
   de Boer IH, 2008, CURR OPIN NEPHROL HY, V17, P566, DOI 10.1097/MNH.0b013e32830fe377
   de Boer IH, 2008, DIABETES CARE, V31, P701, DOI 10.2337/dc07-1829
   DEFRONZO RA, 1981, J CLIN INVEST, V67, P563, DOI 10.1172/JCI110067
   DEFRONZO RA, 1979, AM J PHYSIOL, V237, pE214
   Eknoyan G, 2002, AM J KIDNEY DIS, V39, pS14, DOI 10.1053/ajkd.2002.30939
   Emanuelli B, 2000, J BIOL CHEM, V275, P15985, DOI 10.1074/jbc.275.21.15985
   Esteghamati A, 2009, DIABETES RES CLIN PR, V84, P279, DOI 10.1016/j.diabres.2009.03.005
   Foley RN, 1998, AM J KIDNEY DIS, V32, pS112, DOI 10.1053/ajkd.1998.v32.pm9820470
   Fouque D, 2008, KIDNEY INT, V73, P391, DOI 10.1038/sj.ki.5002585
   Gao ZG, 2003, J BIOL CHEM, V278, P24944, DOI 10.1074/jbc.M300423200
   Gluba A., INT J CARDI IN PRESS
   GOLDBERG AP, 1980, KIDNEY INT, V18, P754, DOI 10.1038/ki.1980.194
   Hadjadj S, 2004, DIABETES METAB, V30, P43, DOI 10.1016/S1262-3636(07)70088-5
   Heiss A, 2003, J BIOL CHEM, V278, P13333, DOI 10.1074/jbc.M210868200
   Hennige AM, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001765
   Ikizler TA, 2008, CURR OPIN NEPHROL HY, V17, P162, DOI 10.1097/MNH.0b013e3282f5dbce
   Ix JH, 2008, JAMA-J AM MED ASSOC, V300, P182, DOI 10.1001/jama.300.2.182
   Kadowaki T, 2006, J CLIN INVEST, V116, P1784, DOI 10.1172/JCI29126
   Kalantar-Zadeh K, 2004, SEMIN DIALYSIS, V17, P455, DOI 10.1111/j.0894-0959.2004.17606.x
   Karakan S, 2012, RENAL FAILURE, V34, P732, DOI 10.3109/0886022X.2012.676493
   Kayacan SM, 2003, CLIN TRANSPLANT, V17, P63, DOI 10.1034/j.1399-0012.2003.02078.x
   Kielstein JT, 2005, AM J KIDNEY DIS, V46, P186, DOI 10.1053/j.ajkd.2005.05.009
   Kleemann R, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008817
   Kobayashi S, 2005, AM J KIDNEY DIS, V45, P275, DOI 10.1053/j.ajkd.2004.09.034
   Kobayashi S, 2000, NEPHROL DIAL TRANSPL, V15, P65, DOI 10.1093/ndt/15.1.65
   Kurella M, 2005, J AM SOC NEPHROL, V16, P2134, DOI 10.1681/ASN.2005010106
   Lajdova I, 2009, NEPHROL DIAL TRANSPL, V24, P3376, DOI 10.1093/ndt/gfp292
   Larsen CM, 2007, NEW ENGL J MED, V356, P1517, DOI 10.1056/NEJMoa065213
   Lee DF, 2008, INT J MOL MED, V22, P633, DOI 10.3892/ijmm_00000065
   Lee PH, 2009, AM J MED SCI, V338, P185, DOI 10.1097/MAJ.0b013e3181a92804
   Lee S, 2004, AEROSPACE AM, V42, P6
   Levin A, 2007, KIDNEY INT, V71, P31, DOI 10.1038/sj.ki.5002009
   LU KC, 1994, Q J MED, V87, P359
   Mak R H, 1983, Kidney Int Suppl, V16, pS128
   MAK RHK, 1986, J CLIN ENDOCR METAB, V63, P985, DOI 10.1210/jcem-63-4-985
   Mak RHK, 1998, KIDNEY INT, V53, P1353, DOI 10.1046/j.1523-1755.1998.00865.x
   MAK RHK, 1992, PEDIATR NEPHROL, V6, P345, DOI 10.1007/BF00869730
   Mak RHK, 1996, J PEDIATR-US, V129, P97, DOI 10.1016/S0022-3476(96)70195-6
   MAK RHK, 1992, NEPHRON, V61, P377, DOI 10.1159/000186953
   Mak RHK, 1996, PEDIATR RES, V40, P304, DOI 10.1203/00006450-199608000-00019
   MANNINEN V, 1992, CIRCULATION, V85, P37, DOI 10.1161/01.CIR.85.1.37
   Mathews ST, 2000, MOL CELL ENDOCRINOL, V164, P87, DOI 10.1016/S0303-7207(00)00237-9
   MCCALEB ML, 1985, J CLIN INVEST, V75, P391, DOI 10.1172/JCI111712
   Melnik BC, 2012, WORLD J DIABETES, V3, P38, DOI 10.4239/wjd.v3.i3.38
   Menon V, 2011, CLIN J AM SOC NEPHRO, V6, P7, DOI 10.2215/CJN.04140510
   Messa P, 2007, NEPHROL DIAL TRANSPL, V22, P2724, DOI 10.1093/ndt/gfm312
   Midtvedt K, 2004, J AM SOC NEPHROL, V15, P3233, DOI 10.1097/01.ASN.0000145435.80005.1E
   Muntner P, 2002, J AM SOC NEPHROL, V13, DOI 10.1681/ASN.V133745
   Nakazato M, 2001, NATURE, V409, P194, DOI 10.1038/35051587
   Nicoletto BB, 2012, J RENAL NUTR, V22, P440, DOI 10.1053/j.jrn.2011.09.003
   Nissen SE, 2007, NEW ENGL J MED, V356, P2457, DOI 10.1056/NEJMoa072761
   Odamaki M, 1999, AM J KIDNEY DIS, V33, P361, DOI 10.1016/S0272-6386(99)70313-6
   Ohashi K, 2007, ARTERIOSCL THROM VAS, V27, P1910, DOI 10.1161/ATVBAHA.107.147645
   Oterdoom LH, 2007, TRANSPLANTATION, V83, P29, DOI 10.1097/01.tp.0000245844.27683.48
   Ottonello L, 2004, J AM SOC NEPHROL, V15, P2366, DOI 10.1097/01.ASN.0000139321.98029.40
   Ouedraogo R, 2007, J CLIN INVEST, V117, P1718, DOI 10.1172/JCI29623
   Oyama Y, 2005, LAB INVEST, V85, P522, DOI 10.1038/labinvest.3700240
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Panchal SK, 2011, J BIOMED BIOTECHNOL, DOI 10.1155/2011/351982
   Peng YS, 2010, NEPHROLOGY, V15, P692, DOI 10.1111/j.1440-1797.2010.01295.x
   Pham H, 2011, CURR OPIN NEPHROL HY, V20, P640, DOI 10.1097/MNH.0b013e32834b23c1
   Plomgaard P, 2005, DIABETES, V54, P2939, DOI 10.2337/diabetes.54.10.2939
   Plomgaard P, 2008, J CLIN ENDOCR METAB, V93, P543, DOI 10.1210/jc.2007-1761
   Pöykkö SM, 2003, DIABETES, V52, P2546, DOI 10.2337/diabetes.52.10.2546
   Ramos LF, 2008, J AM SOC NEPHROL, V19, P593, DOI 10.1681/ASN.2007030355
   Rastmanesh MM, 2008, EUR J PHARMACOL, V593, P99, DOI 10.1016/j.ejphar.2008.07.013
   Rastmanesh MM, 2009, EUR J PHARMACOL, V602, P163, DOI 10.1016/j.ejphar.2008.11.014
   Reinehr T, 2008, J CLIN ENDOCR METAB, V93, P4479, DOI 10.1210/jc.2008-1505
   Rieusset J, 2004, DIABETES, V53, P2232, DOI 10.2337/diabetes.53.9.2232
   Ronn SG, 2007, DIABETES, V56, P541, DOI 10.2337/db06-1068
   ROWE JW, 1981, DIABETES, V30, P219, DOI 10.2337/diab.30.3.219
   Rui LY, 2002, J BIOL CHEM, V277, P42394, DOI 10.1074/jbc.C200444200
   Ryu S, 2009, AM J KIDNEY DIS, V53, P59, DOI 10.1053/j.ajkd.2008.07.027
   Saito A, 2010, J BIOMED BIOTECHNOL, DOI 10.1155/2010/403272
   Samuelsson O, 1998, J AM SOC NEPHROL, V9, P1482
   Satirapoj B, 2007, NEPHROLOGY, V12, P342, DOI 10.1111/j.1440-1797.2007.00770.x
   Semple D, 2011, J AM SOC NEPHROL, V22, P207, DOI 10.1681/ASN.2009090900
   Senn JJ, 2002, DIABETES, V51, P3391, DOI 10.2337/diabetes.51.12.3391
   Sethi JK, 2007, J LIPID RES, V48, P1253, DOI 10.1194/jlr.R700005-JLR200
   Shinohara K, 2002, J AM SOC NEPHROL, V13, P1894, DOI 10.1097/01.ASN.0000019900.87535.43
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Shoji T, 2001, NEPHRON, V89, P348, DOI 10.1159/000046098
   Slee AD, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-36
   Song AY, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019228
   Sowers JR, 2007, KIDNEY INT, V71, P719, DOI 10.1038/sj.ki.5002006
   Stefan N, 2008, DIABETES, V57, P2762, DOI 10.2337/db08-0538
   Stenvinkel P, 1998, NEPHROL DIAL TRANSPL, V13, P1099, DOI 10.1093/ndt/13.5.1099
   Taniguchi CM, 2006, NAT REV MOL CELL BIO, V7, P85, DOI 10.1038/nrm1837
   Teta D, 2012, J RENAL NUTR, V22, P81, DOI 10.1053/j.jrn.2011.10.029
   Thomas G, 2011, CLIN J AM SOC NEPHRO, V6, P2364, DOI 10.2215/CJN.02180311
   Tozawa M, 2002, KIDNEY INT, V62, P1743, DOI 10.1046/j.1523-1755.2002.00626.x
   Tsimihodimos V, 2008, AM J NEPHROL, V28, P958, DOI 10.1159/000144024
   Ueki K, 2004, MOL CELL BIOL, V24, P5434, DOI 10.1128/MCB.24.12.5434-5446.2004
   Vos FE, 2011, NEPHROLOGY, V16, P68, DOI 10.1111/j.1440-1797.2010.01329.x
   Wang AYM, 2005, NEPHROL DIAL TRANSPL, V20, P1676, DOI 10.1093/ndt/gfh891
   Wang CC, 2012, CLIN NEPHROL, V77, P89, DOI [10.5414/CN106757, 10.10.5414/CN106757]
   Wesoly J, 2010, ACTA BIOCHIM POL, V57, P251
   Winbanks CE, 2011, J BIOMED BIOTECHNOL, DOI 10.1155/2011/212819
   Xu Y, 2011, ATHEROSCLEROSIS, V216, P180, DOI 10.1016/j.atherosclerosis.2011.01.020
   Yamamoto T, 2010, NEPHROL DIAL TRANSPL, V25, P4017, DOI 10.1093/ndt/gfq329
   Yamauchi T, 2001, NAT MED, V7, P941, DOI 10.1038/90984
   Yilmaz MI, 2008, NEPHROL DIAL TRANSPL, V23, P959, DOI 10.1093/ndt/gfm727
   Yki-Jarvinen H, 2004, NEW ENGL J MED, V351, P1106, DOI 10.1056/NEJMra041001
   Zhang KZ, 2008, NATURE, V454, P455, DOI 10.1038/nature07203
   Zhao LC, 2010, J BIOMED BIOTECHNOL, DOI 10.1155/2010/431894
   Zheng CM, 2012, CLIN CHIM ACTA, V413, P1555, DOI 10.1016/j.cca.2012.04.025
   Zoccali C, 2002, J AM SOC NEPHROL, V13, P134, DOI 10.1681/ASN.V131134
NR 138
TC 97
Z9 103
U1 0
U2 20
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1110-7243
EI 1110-7251
J9 J BIOMED BIOTECHNOL
JI J. Biomed. Biotechnol.
PY 2012
AR 691369
DI 10.1155/2012/691369
PG 12
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 997UG
UT WOS:000308191600001
PM 22919275
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Fukushima, M
   Okamoto, Y
   Katsumata, H
   Ishikawa, M
   Ishii, S
   Okamoto, M
   Minami, S
AF Fukushima, M.
   Okamoto, Y.
   Katsumata, H.
   Ishikawa, M.
   Ishii, S.
   Okamoto, M.
   Minami, S.
TI Growth Hormone Ameliorates Adipose Dysfunction During Oxidative Stress
   and Inflammation and Improves Glucose Tolerance in Obese Mice
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE growth hormone; adipose tissue; oxidative stress; inflammation;
   adiponectin; glucose tolerance
ID DIET-INDUCED OBESITY; METABOLIC SYNDROME; BODY-COMPOSITION;
   INSULIN-RESISTANCE; CRUCIAL ROLE; MOUSE MODEL; IGF-I; ADIPONECTIN;
   TISSUE; FAT
AB Patients with adult growth hormone deficiency exhibit visceral fat accumulation, which gives rise to a cluster of metabolic disorders such as impaired glucose tolerance and dyslipidemia. Plasma growth hormone levels are lower in obese patients with metabolic syndrome than in healthy subjects. Here we examined the hypothesis that exogenous growth hormone administration regulates function of adipose tissue to improve glucose tolerance in diet-induced obese mice. Twelve-week-old obese male C57BL/6J mice received bovine growth hormone daily for 6 weeks. In epididymal fat, growth hormone treatment antagonized diet-induced changes in the gene expression of adiponectin, leptin, and monocyte chemoattractant protein-1, and significantly increased the gene expression of interleukin-10 and CD206. Growth hormone also suppressed the accumulation of oxidative stress marker, thiobarbituric acid-reactive substances, in the epididymal fat and enhanced the gene expression of anti-oxidant enzymes. Moreover, growth hormone significantly restored glucose tolerance in obese mice. In cultured 3T3-L1 adipocytes, growth hormone prevented the decline in adiponectin gene expression in the presence of hydrogen peroxide. These results suggest that growth hormone administration ameliorates glucose intolerance in obese mice presumably by decreasing adipose mass, oxidative stress, and chronic inflammation in the visceral fat.
C1 [Fukushima, M.; Okamoto, Y.; Katsumata, H.; Ishii, S.; Okamoto, M.; Minami, S.] Nippon Med Sch, Dept Bioregulat, Kawasaki, Kanagawa 2118533, Japan.
   [Okamoto, Y.; Ishikawa, M.; Minami, S.] Musashi Kosugi Hosp, Nippon Med Sch, Div Endocrinol Diabetol & Atherosclerosis Med, Kawasaki, Kanagawa, Japan.
C3 Nippon Medical School; Nippon Medical School
RP Okamoto, Y (corresponding author), Nippon Med Sch, Dept Bioregulat, Nakahara Ku, 1-396 Kosugi Machi, Kawasaki, Kanagawa 2118533, Japan.
EM yokamoto@nms.ac.jp
CR Attanasio AF, 2002, J CLIN ENDOCR METAB, V87, P1600, DOI 10.1210/jc.87.4.1600
   BESHYAH SA, 1995, CLIN ENDOCRINOL, V42, P179, DOI 10.1111/j.1365-2265.1995.tb01860.x
   Bielohuby M, 2011, ENDOCRINOLOGY, V152, P4764, DOI 10.1210/en.2011-1432
   Carroll PV, 1998, J CLIN ENDOCR METAB, V83, P382, DOI 10.1210/jc.83.2.382
   Chen W, 2011, J BIOL CHEM, V286, P34559, DOI 10.1074/jbc.M111.285965
   Colao A, 2002, J CLIN ENDOCR METAB, V87, P3097, DOI 10.1210/jc.87.7.3097
   Ding J, 2011, ENDOCRINOLOGY, V152, P3791, DOI 10.1210/en.2011-1217
   Frick F, 2001, AM J PHYSIOL-ENDOC M, V281, pE1230, DOI 10.1152/ajpendo.2001.281.6.E1230
   Friedman JM, 2009, NATURE, V459, P340, DOI 10.1038/459340a
   Fujisaka S, 2009, DIABETES, V58, P2574, DOI 10.2337/db08-1475
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Hoffman AR, 2004, J CLIN ENDOCR METAB, V89, P2048, DOI 10.1210/jc.2003-030346
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Iwaki M, 2003, DIABETES, V52, P1655, DOI 10.2337/diabetes.52.7.1655
   Kamada Y, 2007, J HEPATOL, V47, P556, DOI 10.1016/j.jhep.2007.03.020
   Kanda H, 2006, J CLIN INVEST, V116, P1494, DOI 10.1172/JCI26498
   Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2548, DOI 10.1210/jc.2004-0395
   Kumada M, 2004, CIRCULATION, V109, P2046, DOI 10.1161/01.CIR.0000127953.98131.ED
   List EO, 2009, DIABETOLOGIA, V52, P1647, DOI 10.1007/s00125-009-1402-z
   Lubbers ER, 2013, J ENDOCRINOL, V216, P363, DOI 10.1530/JOE-12-0505
   Maeda N, 2001, DIABETES, V50, P2094, DOI 10.2337/diabetes.50.9.2094
   Matsuzawa Y, 2006, FEBS LETT, V580, P2917, DOI 10.1016/j.febslet.2006.04.028
   Matsuzawa Y, 2011, J ATHEROSCLER THROMB, V18, P629, DOI 10.5551/jat.7922
   Minamino T, 2009, NAT MED, V15, P1082, DOI 10.1038/nm.2014
   MOLLER N, 1990, AM J PHYSIOL, V258, pE86, DOI 10.1152/ajpendo.1990.258.1.E86
   Ohashi K, 2010, J BIOL CHEM, V285, P6153, DOI 10.1074/jbc.M109.088708
   Okamoto Y, 2006, CLIN SCI, V110, P267, DOI 10.1042/CS20050182
   Olsson B, 2005, ENDOCRINOLOGY, V146, P920, DOI 10.1210/en.2004-1232
   VELDHUIS JD, 1991, J CLIN ENDOCR METAB, V72, P51, DOI 10.1210/jcem-72-1-51
   Velloso CP, 2008, BRIT J PHARMACOL, V154, P557, DOI 10.1038/bjp.2008.153
   Vilar Lucio, 2007, Endocr Pract, V13, P363
   Wellen KE, 2003, J CLIN INVEST, V112, P1785, DOI 10.1172/JCI20514
   Wisse BE, 2004, J AM SOC NEPHROL, V15, P2792, DOI 10.1097/01.ASN.0000141966.69934.21
   Wu YJ, 2011, J CLIN INVEST, V121, P2422, DOI 10.1172/JCI45027
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
NR 35
TC 12
Z9 12
U1 0
U2 2
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD AUG
PY 2014
VL 46
IS 9
BP 656
EP 662
DI 10.1055/s-0034-1381998
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AO1UI
UT WOS:000341100000010
PM 24995855
DA 2025-06-11
ER

PT J
AU Cesarone, MR
   Di Renzo, A
   Errichi, S
   Schönlau, F
   Wilmer, JL
   Blumenfeld, J
AF Cesarone, Maria R.
   Di Renzo, Andrea
   Errichi, Silvia
   Schonlau, Frank
   Wilmer, James L.
   Blumenfeld, Julian
TI Improvement in circulation and in cardiovascular risk factors with a
   proprietary isotonic bioflavonoid formula OPC-3®
SO ANGIOLOGY
LA English
DT Article
DE bioflavonoid; OPC-3; metabolic syndrome; isotonic; cardiovascular risk
   factors; pycnogenol
ID OXIDATIVE STRESS; POLYPHENOLS; ANTIOXIDANTS; PREVENTION; DISEASE; PLASMA
AB This study investigated the efficacy of isotonic bioflavonoid Supplementation, OPC-3 on 61 individuals presenting with risk factors meeting the criteria for metabolic syndrome. Subjects were supplemented with a proprietary isotonic bioflavonoid OPC-3 or placebo over 2 months. Plasma oxidative stress status was significantly lowered by 10.1% with OPC-3. All major cardiovascular risk factors were improved with blood pressure, total cholesterol, and Fasting blood glucose lowered. OPC-3 significantly improved endothelial function as evaluated by increased vasorelaxation in reactive hyperemia and enhanced diastolic carotid artery flow. Cardiac ultrasound scanning revealed a significant increase of left ventricular ejection fraction. Skin microcirculation was enhanced, and better tissue perfusion led to significantly increased transcutaneous Oxygen partial pressure and decreased pCO(2). With OPC-3 a dramatic and significant plasma C-reactive protein decrease by 52.1% occurred. Individuals may improve key cardiovascular risk Factors by daily Supplementation with the bioflavonoid OPC-3 as an important part of a healthier lifestyle.
C1 [Wilmer, James L.; Blumenfeld, Julian] NutraMetrix, Div Market Amer, Greensboro, NC 27409 USA.
   [Cesarone, Maria R.; Di Renzo, Andrea] Univ G dAnnunzio, Dept Biomed Sci, Pescara, Italy.
   [Schonlau, Frank] Horphag Res UK, London, England.
C3 G d'Annunzio University of Chieti-Pescara
RP Blumenfeld, J (corresponding author), NutraMetrix, Div Market Amer, 1302 Pleasant Ridge Rd, Greensboro, NC 27409 USA.
EM nutramextix@nutrametrix.com
CR [Anonymous], 2001, Altern Med Rev, V6, P500
   Belcaro G, 2004, CLIN APPL THROMB-HEM, V10, P373, DOI 10.1177/107602960401000410
   Cesarone MR, 2006, CLIN APPL THROMB-HEM, V12, P205, DOI 10.1177/107602960601200209
   Cheynier V, 2005, AM J CLIN NUTR, V81, p223S, DOI 10.1093/ajcn/81.1.223S
   Clifford MN, 2004, PLANTA MED, V70, P1103, DOI 10.1055/s-2004-835835
   Garg A, 2001, PHYTOTHER RES, V15, P655, DOI 10.1002/ptr.1074
   Gaté L, 1999, BIOMED PHARMACOTHER, V53, P169, DOI 10.1016/S0753-3322(99)80086-9
   Grimm Tanja, 2006, J Inflamm (Lond), V3, P1, DOI 10.1186/1476-9255-3-1
   Higashi Y, 1999, HYPERTENSION, V33, P591, DOI 10.1161/01.HYP.33.1.591
   Hou DX, 2004, J BIOMED BIOTECHNOL, P321, DOI 10.1155/S1110724304403040
   Komatsu F, 2006, NUTR METAB, V3, DOI 10.1186/1743-7075-3-21
   Matsumoto H, 2003, J AGR FOOD CHEM, V51, P3560, DOI 10.1021/jf034132y
   McDougall GJ, 2005, BIOFACTORS, V23, P189, DOI 10.1002/biof.5520230403
   Middleton E, 2000, PHARMACOL REV, V52, P673
   Opie LH, 2007, EUR HEART J, V28, P1683, DOI 10.1093/eurheartj/ehm149
   Pervaiz S, 2003, FASEB J, V17, P1975, DOI 10.1096/fj.03-0168rev
   Ridker PM, 2003, CIRCULATION, V107, P363, DOI 10.1161/01.CIR.0000053730.47739.3C
   Rohdewald P.J., 2005, Encycl. Diet. Suppl, V1, P545, DOI DOI 10.1201/B13959-57
   Scalbert A, 2005, AM J CLIN NUTR, V81, p215S, DOI 10.1093/ajcn/81.1.215S
   Schiller N B, 1989, J Am Soc Echocardiogr, V2, P358
   Shi John, 2003, Journal of Medicinal Food, V6, P291, DOI 10.1089/109662003772519831
   SZENTGYORGI A, 1938, PHYSIOL CHEM PHYS M, V225, P126
   Thomas JD, 2006, J AM COLL CARDIOL, V48, P2012, DOI 10.1016/j.jacc.2006.06.071
   *US PHARM CONV INC, 2005, US PHARM, P2115
   Zern TL, 2005, J NUTR, V135, P1911, DOI 10.1093/jn/135.8.1911
NR 25
TC 5
Z9 5
U1 0
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD AUG-SEP
PY 2008
VL 59
IS 4
BP 408
EP 414
DI 10.1177/0003319708321801
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 348YB
UT WOS:000259244900003
PM 18628275
DA 2025-06-11
ER

PT J
AU Jadhav, R
   Dodd, T
   Smith, E
   Bailey, E
   DeLucia, AL
   Russell, JC
   Madison, R
   Potter, B
   Walsh, K
   Jo, HJ
   Rocic, P
AF Jadhav, Rashmi
   Dodd, Tracy
   Smith, Erika
   Bailey, Erin
   DeLucia, Angelo L.
   Russell, James C.
   Madison, Rowan
   Potter, Barry
   Walsh, Kenneth
   Jo, Hanjoong
   Rocic, Petra
TI Angiotensin type I receptor blockade in conjunction with enhanced Akt
   activation restores coronary collateral growth in the metabolic syndrome
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE transient; coronary artery occlusion
ID ISCHEMIA-INDUCED ANGIOGENESIS; NITRIC-OXIDE SYNTHASE; ENDOTHELIAL-CELLS;
   KINASE; RAT; INHIBITION; STRESS; SYSTEM; ARTERY
AB Jadhav R, Dodd T, Smith E, Bailey E, DeLucia AL, Russell JC, Madison R, Potter B, Walsh K, Jo H, Rocic P. Angiotensin type I receptor blockade in conjunction with enhanced Akt activation restores coronary collateral growth in the metabolic syndrome. Am J Physiol Heart Circ Physiol 300: H1938-H1949, 2011. First published February 18, 2011; doi:10.1152/ajpheart.00282.2010.-We have previously demonstrated that Akt was required for repetitive ischemia (RI)-induced coronary collateral growth (CCG) in healthy rats but was not activated by RI in the metabolic syndrome (JCR:LA-cp rats) where CCG was impaired. Here we hypothesized that failure of angiotensin type I receptor (AT(1)R) blockers to restore Akt activation is a key determinant of their inability to completely restore CCG in the metabolic syndrome. Therefore, we investigated whether adenovirus-mediated delivery of constitutively active Akt (MyrAkt-Adv.) in conjunction with AT(1)R blockade (candesartan) was able to restore RI-induced CCG in JCR:LA-cp rats. Successful myocardial MyrAkt-Adv delivery was confirmed by a >80% transduction efficiency and an approximately fourfold increase in Akt expression and activation. CCG was assessed by myocardial blood flow measurements in the normal and collateral-dependent zones. MyrAkt-Adv alone significantly increased RI-induced CCG in JCR:LA-cp rats (similar to 30%), but it completely restored CCG in conjunction with administration of candesartan. In contrast, dominant negative Akt (DN-Akt-Adv) reversed the beneficial effect of candesartan on CCG in JCR:LA-cp rats. We conclude that optimal restoration of coronary collateral growth in JCR:LA-cp rats requires a combination of AT(1)R blockade with constitutive Akt activation. These findings may carry implications for metabolic syndrome patients in need of coronary revascularization.
C1 [Rocic, Petra] Univ S Alabama, Dept Biochem & Mol Biol, Coll Med, Mobile, AL 36688 USA.
   [Bailey, Erin; DeLucia, Angelo L.] Northeastern Ohio Univ Coll Med & Pharm, Coll Med, Dept Integrat Med Sci, Rootstown, OH 44272 USA.
   [Russell, James C.] Univ Alberta, Alberta Inst Human Nutr, Metab & Cardiovasc Dis Lab, Edmonton, AB, Canada.
   [Madison, Rowan; Potter, Barry] Louisiana State Univ, Hlth Sci Ctr, Dept Physiol, New Orleans, LA USA.
   [Walsh, Kenneth] Boston Univ, Sch Med, Whitaker Cardiovasc Inst, Boston, MA 02118 USA.
   [Jo, Hanjoong] Emory Univ, Coulter Dept Biomed Engn, Georgia Inst Technol, Atlanta, GA 30322 USA.
   [Jo, Hanjoong] Emory Univ, Dept Med, Div Cardiol, Atlanta, GA 30322 USA.
C3 University of South Alabama; University System of Ohio; Northeast Ohio
   Medical University (NEOMED); University of Alberta; Louisiana State
   University System; Louisiana State University Health Sciences Center New
   Orleans; Boston University; Emory University; University System of
   Georgia; Georgia Institute of Technology; Emory University
RP Rocic, P (corresponding author), Univ S Alabama, Dept Biochem & Mol Biol, Coll Med, 307 N Univ Blvd, Mobile, AL 36688 USA.
EM procic@usouthal.edu
RI JADHAV, RASHMI/GQI-2890-2022; Jo, Hanjoong/L-6216-2019
OI Rocic, Petra/0000-0002-5781-3075; Jo, Hanjoong/0000-0003-1833-372X
FU National Heart, Lung, and Blood Institute [R01-HL-093052]
FX This work was supported by National Heart, Lung, and Blood Institute
   Grant R01-HL-093052.
CR Ackah E, 2005, J CLIN INVEST, V115, P2119, DOI 10.1172/JCI24726
   Boo YC, 2002, J BIOL CHEM, V277, P3388, DOI 10.1074/jbc.M108789200
   Bussolati B, 2001, AM J PATHOL, V159, P993, DOI 10.1016/S0002-9440(10)61775-0
   Cai WJ, 2003, AM J PHYSIOL-HEART C, V284, pH31, DOI 10.1152/ajpheart.00478.2002
   Chen JS, 2009, HEPATOL RES, V39, P177, DOI 10.1111/j.1872-034X.2008.00449.x
   Dimmeler S, 1999, NATURE, V399, P601, DOI 10.1038/21224
   Dulak J, 2003, ANTIOXID REDOX SIGN, V5, P123, DOI 10.1089/152308603321223612
   Hayashi K, 1999, J CELL BIOL, V145, P727, DOI 10.1083/jcb.145.4.727
   Hughes GC, 2005, EXPERT REV CARDIOVAS, V3, P521, DOI 10.1586/14779072.3.3.521
   Iglarz M, 2001, ARTERIOSCL THROM VAS, V21, P1598, DOI 10.1161/hq1001.097065
   Kawahara S, 2005, J CARDIOVASC PHARM, V45, P367, DOI 10.1097/01.fjc.0000157454.60939.43
   Koerselman J, 2003, CIRCULATION, V107, P2507, DOI 10.1161/01.CIR.0000065118.99409.5F
   Lee SU, 2006, TOXICOL PATHOL, V34, P3, DOI 10.1080/01926230500499415
   Liao JK, 2008, CIRC RES, V103, P229, DOI 10.1161/CIRCRESAHA.108.181628
   Liu P, 2006, CAN J CARDIOL, V22, p25B, DOI 10.1016/S0828-282X(06)70983-7
   Madeddu P, 2008, ARTERIOSCL THROM VAS, V28, P68, DOI 10.1161/ATVBAHA.107.145573
   Maulik N, 2002, J CELL MOL MED, V6, P13, DOI 10.1111/j.1582-4934.2002.tb00308.x
   Miller SJ, 2007, AM J PHYSIOL-HEART C, V292, pH2523, DOI 10.1152/ajpheart.01296.2006
   Miyauchi H, 2004, EMBO J, V23, P212, DOI 10.1038/sj.emboj.7600045
   O'Neill BT, 2005, J CLIN INVEST, V115, P2059, DOI 10.1172/JCI25900
   Reed R, 2008, ARTERIOSCL THROM VAS, V28, P61, DOI 10.1161/ATVBAHA.107.154294
   Reed R, 2009, AM J PHYSIOL-HEART C, V296, pH1811, DOI 10.1152/ajpheart.00920.2008
   Risinger GM, 2006, J BIOL CHEM, V281, P25915, DOI 10.1074/jbc.M513513200
   Rocic P, 2007, AM J PHYSIOL-HEART C, V292, pH2729, DOI 10.1152/ajpheart.01330.2006
   Ruggero D, 2005, ONCOGENE, V24, P7426, DOI 10.1038/sj.onc.1209098
   Russell JC, 2009, BRIT J PHARMACOL, V158, P1588, DOI 10.1111/j.1476-5381.2009.00417.x
   Russell JC, 1998, J CARDIOVASC PHARM, V31, P971, DOI 10.1097/00005344-199806000-00024
   Russell JC, 2007, ANIMAL MODELS DIABET
   Sasaki K, 2002, J CLIN INVEST, V109, P603, DOI 10.1172/JCI200213055
   Schaper W, 2009, BASIC RES CARDIOL, V104, P5, DOI 10.1007/s00395-008-0760-x
   Shiojima I, 2005, J CLIN INVEST, V115, P2108, DOI 10.1172/JCI24682
   Shiojima I, 2006, GENE DEV, V20, P3347, DOI 10.1101/gad.1492806
   Silvestre JS, 2002, CIRC RES, V90, P1072, DOI 10.1161/01.RES.0000019892.41157.24
   Toblli JE, 2004, AM J HYPERTENS, V17, P172, DOI 10.1016/j.amjhyper.2003.10.006
   Toyota E, 2005, CIRCULATION, V112, P2108, DOI 10.1161/CIRCULATIONAHA.104.526954
   Vander Haar E, 2007, NAT CELL BIOL, V9, P316, DOI 10.1038/ncb1547
   Walther T, 2003, FASEB J, V17, P2061, DOI 10.1096/fj.03-0129com
NR 37
TC 13
Z9 15
U1 0
U2 2
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD MAY
PY 2011
VL 300
IS 5
BP H1938
EP H1949
DI 10.1152/ajpheart.00282.2010
PG 12
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 757NA
UT WOS:000290092800042
PM 21335466
OA Green Published
DA 2025-06-11
ER

PT J
AU Vergès, B
AF Vergès, B
TI Clinical interest of PPARs ligands -: Particular benefit in type 2
   diabetes and metabolic syndrome
SO DIABETES & METABOLISM
LA English
DT Review
DE diabetes; metabolic syndrome; PPAR fibrate; glitazone
ID IMPROVES GLYCEMIC CONTROL; CORONARY-HEART-DISEASE;
   PROLIFERATOR-ACTIVATED RECEPTORS; VASCULAR ENDOTHELIAL-CELLS;
   PIOGLITAZONE HYDROCHLORIDE; ROSIGLITAZONE MONOTHERAPY; GENE-EXPRESSION;
   GAMMA LIGANDS; FATTY-ACIDS; ALPHA
AB Cardiovascular disease is significantly increased in patients with metabolic syndrome and type 2 diabetes. Several factors such as chronic hyperglycemia, lipid abnormalities, endothelium dysfunction, inflammation, oxidative stress, increased thrombosis and decreased fibrinolysis are likely to promote cardiovascular events in these patients. Because of positive effects on glucose homeostasis, lipid metabolism, proteins involved in all stages of atherogenesis, endothelium function, inflammation, thrombosis and fibrinolysis, PPARS alpha (fibrates) and PPARs gamma (glitazones) agonists are good candidates to reduce cardiovascular disease, more precisely in subjects with metabolic syndrome or type 2 diabetes. PPARS a agonists (fibrates) are potent hypolipidemic agents increasing plasma HDL-cholesterol and reducing free fatty acids, triglycerides, LDL-cholesterol and the number of small dense LDL particles. Moreover, they reduce vascular inflammation and thrombosis, promote fibrinolysis and inhibit the production of the vasoconstrictor factor, endothelin-1, by the endothelium. They have been shown, in clinical trials, to reduce cardiovascular disease, more particularly in patients displaying lipid abnormalities typical of metabolic syndrome and type 2 diabetes (high triglycerides, low HDL-cholesterol). PPARS gamma agonists (glitazones) have not only beneficial effects on glucose homeostasis, by increasing insulin sensitivity and reducing blood glucose level but also on lipid metabolism by elevating plasma HDL-cholesterol, decreasing free fatty acids and the number of small dense LDL particles, and for pioglitazone by reducing plasma triglycerides. Furthermore, they diminish vascular inflammation and vasoconstriction, inhibit monocyte chemotaxis, proliferation and migration of smooth muscle cells, in the vascular wall and decrease the production of adhesion molecules and metalloproteinases. PPARs gamma agonists (glitazones) have been shown to reduce the development of atherosclerotic lesions in rats. The potential clinical benefit of PPARs gamma agonists on the reduction of cardiovascular disease, in type 2 diabetic patients, will be specified by the ongoing intervention studies.
C1 CHU Dijon, Hop Bocage, Serv Endocrinol Diabetol & Maladies Metabol, F-21000 Dijon, France.
C3 Universite Bourgogne Europe; CHU Dijon Bourgogne
RP CHU Dijon, Hop Bocage, Serv Endocrinol Diabetol & Maladies Metabol, F-21000 Dijon, France.
EM bruno.verges@chu-dijon.fr
CR Aronoff S, 2000, DIABETES CARE, V23, P1605, DOI 10.2337/diacare.23.11.1605
   Bodzioch M, 1999, NAT GENET, V22, P347, DOI 10.1038/11914
   Brooks-Wilson A, 1999, NAT GENET, V22, P336, DOI 10.1038/11905
   BRUCKERT E, 1993, ATHEROSCLEROSIS, V100, P91, DOI 10.1016/0021-9150(93)90071-2
   Brunzell J, 2001, DIABETES, V50, pA141
   Chiba Y, 2001, BIOCHEM BIOPH RES CO, V286, P541, DOI 10.1006/bbrc.2001.5361
   Chinetti G, 2000, CIRCULATION, V101, P2411, DOI 10.1161/01.CIR.101.20.2411
   Chinetti G, 2001, NAT MED, V7, P53, DOI 10.1038/83348
   Collins AR, 2001, ARTERIOSCL THROM VAS, V21, P365, DOI 10.1161/01.ATV.21.3.365
   Delerive P, 1999, CIRC RES, V85, P394, DOI 10.1161/01.RES.85.5.394
   Desvergne B, 1999, ENDOCR REV, V20, P649, DOI 10.1210/er.20.5.649
   Durrington PN, 1998, ATHEROSCLEROSIS, V138, P217, DOI 10.1016/S0021-9150(98)00003-3
   Einhorn D, 2000, CLIN THER, V22, P1395, DOI 10.1016/S0149-2918(00)83039-8
   Fonseca V, 2000, JAMA-J AM MED ASSOC, V283, P1695, DOI 10.1001/jama.283.13.1695
   FRICK MH, 1987, NEW ENGL J MED, V317, P1237, DOI 10.1056/NEJM198711123172001
   Fruchart JC, 2001, AM J CARDIOL, V88, p24N
   Fruchart JC, 1999, CURR OPIN LIPIDOL, V10, P245, DOI 10.1097/00041433-199906000-00007
   Iozzo P, 2003, DIABETES CARE, V26, P2069, DOI 10.2337/diacare.26.7.2069
   Jiang CY, 1998, NATURE, V391, P82, DOI 10.1038/34184
   Kipnes MS, 2001, AM J MED, V111, P10, DOI 10.1016/S0002-9343(01)00713-6
   Kockx M, 1999, BLOOD, V93, P2991
   Koshiyama H, 2001, J CLIN ENDOCR METAB, V86, P3452, DOI 10.1210/jc.86.7.3452
   Law RE, 2000, CIRCULATION, V101, P1311, DOI 10.1161/01.CIR.101.11.1311
   Lebovitz HE, 2001, J CLIN ENDOCR METAB, V86, P280, DOI 10.1210/jc.86.1.280
   Madej A, 1998, INT J CLIN PHARM TH, V36, P345
   MANNINEN V, 1988, JAMA-J AM MED ASSOC, V260, P641, DOI 10.1001/jama.260.5.641
   MANNINEN V, 1992, CIRCULATION, V85, P37, DOI 10.1161/01.CIR.85.1.37
   Marx N, 1999, CIRCULATION, V99, P3125, DOI 10.1161/01.CIR.99.24.3125
   Marx N, 2003, ARTERIOSCL THROM VAS, V23, P283, DOI 10.1161/01.ATV.0000054195.35121.5E
   Marx N, 1998, CIRC RES, V83, P1097, DOI 10.1161/01.RES.83.11.1097
   Marx N, 1998, AM J PATHOL, V153, P17, DOI 10.1016/S0002-9440(10)65540-X
   Marx N, 2001, CIRCULATION, V103, P213
   Miyazaki Y, 2002, J CLIN ENDOCR METAB, V87, P2784, DOI 10.1210/jc.87.6.2784
   Murao K, 1999, FEBS LETT, V454, P27, DOI 10.1016/S0014-5793(99)00765-6
   Nakamura T, 2000, J DIABETES COMPLICAT, V14, P250, DOI 10.1016/S1056-8727(00)00124-0
   Nawa T, 2000, BIOCHEM BIOPH RES CO, V275, P406, DOI 10.1006/bbrc.2000.3332
   Okopien B, 2001, INT J CLIN PHARM TH, V39, P551
   OVALLE B, 2001, DIABETES, V51, pA457
   Ricote M, 1999, J LEUKOCYTE BIOL, V66, P733, DOI 10.1002/jlb.66.5.733
   Rosen ED, 2000, J CLIN INVEST, V106, P629, DOI 10.1172/JCI10909
   Rubins HB, 1999, NEW ENGL J MED, V341, P410, DOI 10.1056/NEJM199908053410604
   Satoh H, 1999, BIOCHEM BIOPH RES CO, V254, P757, DOI 10.1006/bbrc.1998.0126
   SCHOONJANS K, 1995, J BIOL CHEM, V270, P19269, DOI 10.1074/jbc.270.33.19269
   Schoonjans K, 1996, J LIPID RES, V37, P907
   Staels B, 1998, CIRCULATION, V98, P2088, DOI 10.1161/01.CIR.98.19.2088
   Staels B, 1998, NATURE, V393, P790, DOI 10.1038/31701
   Verges B, 2002, ANN ENDOCRINOL-PARIS, V63, pS45
   Wayman NS, 2002, FASEB J, V16, P1027, DOI 10.1096/fj.01-0793com
   Winkler K., 2002, BR J DIABETES VASC D, V2, DOI [10.1177/14746514020020021301, DOI 10.1177/14746514020020021301]
   Wolffenbuttel BHR, 2000, DIABETIC MED, V17, P40, DOI 10.1046/j.1464-5491.2000.00224.x
NR 50
TC 84
Z9 90
U1 0
U2 3
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 1262-3636
EI 1878-1780
J9 DIABETES METAB
JI Diabetes Metab.
PD FEB
PY 2004
VL 30
IS 1
BP 7
EP 12
DI 10.1016/S1262-3636(07)70083-6
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 810IB
UT WOS:000220696900001
PM 15029092
DA 2025-06-11
ER

PT J
AU Hales, CN
   Ozanne, SE
AF Hales, CN
   Ozanne, SE
TI For Debate: Fetal and early postnatal growth restriction lead to
   diabetes, the metabolic syndrome and renal failure
SO DIABETOLOGIA
LA English
DT Article
DE Type 2 diabetes; metabolic syndrome; renal failure; fetal growth
   restriction; programming; epigenetic; longevity; telomeres; thrifty
   phenotype hypothesis; low-protein diet
ID THRIFTY PHENOTYPE HYPOTHESIS; IMPAIRED GLUCOSE-TOLERANCE; MATERNAL IRON
   RESTRICTION; PROTEIN-MALNOURISHED RATS; CORONARY-HEART-DISEASE;
   LOW-BIRTH-WEIGHT; BLOOD-PRESSURE; SIGNAL-TRANSDUCTION;
   INSULIN-RESISTANCE; ENDOCRINE PANCREAS
AB We review the progress in testing the thrifty phenotype hypothesis. Many human epidemiological studies both by ourselves and others have confirmed and extended the original observations on which the hypothesis was based. We are not aware of any contradictory findings and we emphasise the strength of the association between birth weight and the subsequent development of the metabolic syndrome. We have worked extensively experimentally to test the hypothesis in a rat model in which pregnant and/or lactating dams are fed a diet moderately restricted in proteins. The range of programming effects that we have discovered in this example of fetal and early postnatal growth restriction is listed and includes changes in hormone receptors, signalling molecules and regulatory enzymes. We have shown the model to develop diabetes, the metabolic syndrome and signs of premature renal failure. We summarise these and other similarities between the phenotype of this model and human Type 2 diabetes and the metabolic syndrome. The number of insults during early development which can lead to a similar outcome is discussed and the suggestion is made that the early life response to stress is limited in its flexibility with outcomes including ageing and decreased longevity. Our preliminary results indicate that some MODY genes could suggest pathways whereby the changes occur and that epigenetic changes during development are involved. We conclude that the way is now clear to discover early human markers of programming by early life growth restriction and to use these to devise strategies for the prevention of Type 2 diabetes.
C1 Addenbrookes Hosp, Dept Clin Biochem, Cambridge CB2 2QR, England.
   Univ Cambridge, Dept Clin Biochem, Cambridge, England.
C3 Cambridge University Hospitals NHS Foundation Trust; Addenbrooke's
   Hospital; University of Cambridge; University of Cambridge
RP Addenbrookes Hosp, Dept Clin Biochem, Hills Rd, Cambridge CB2 2QR, England.
EM chn1000@cam.ac.uk
OI Ozanne, Susan/0000-0001-8753-5144
CR Adams SP, 2001, P ROY SOC B-BIOL SCI, V268, P1541, DOI 10.1098/rspb.2001.1726
   Baird J, 2001, DIABETOLOGIA, V44, P33, DOI 10.1007/s001250051577
   BANERJI MA, 1995, DIABETES, V44, P141, DOI 10.2337/diabetes.44.2.141
   BARKER DJP, 1993, DIABETOLOGIA, V36, P62, DOI 10.1007/BF00399095
   Björnholm M, 2002, DIABETOLOGIA, V45, P1128, DOI 10.1007/s00125-002-0875-9
   Bo S, 2000, DIABETIC MED, V17, P365, DOI 10.1046/j.1464-5491.2000.00288.x
   BROWN DC, 1991, DIABETOLOGIA, V34, P531, DOI 10.1007/BF00403292
   BRUCE DG, 1992, DIABETOLOGIA, V35, P835, DOI 10.1007/BF00399929
   Cross G, 1998, TIME SOC, V7, P5, DOI 10.1177/0961463X98007001001
   Desai M, 1997, AM J PHYSIOL-GASTR L, V272, pG1083, DOI 10.1152/ajpgi.1997.272.5.G1083
   Eriksson JG, 1999, BMJ-BRIT MED J, V318, P427, DOI 10.1136/bmj.318.7181.427
   Forsén T, 2000, ANN INTERN MED, V133, P176, DOI 10.7326/0003-4819-133-3-200008010-00008
   FRANK JW, 1995, GASTROENTEROLOGY, V109, P755, DOI 10.1016/0016-5085(95)90382-8
   Fryer MJ, 2000, NEPHROLOGY, V5, P1, DOI 10.1046/j.1440-1797.2000.00504.x
   GEBHARDT R, 1992, PHARMACOL THERAPEUT, V53, P275, DOI 10.1016/0163-7258(92)90055-5
   HALES CN, 1992, DIABETOLOGIA, V35, P595, DOI 10.1093/ije/dyt133
   HALES CN, 1991, BMJ-BRIT MED J, V303, P1019, DOI 10.1136/bmj.303.6809.1019
   Hales CN, 2001, BRIT MED BULL, V60, P5, DOI 10.1093/bmb/60.1.5
   Hales CN, 1996, BIOCHEM SOC T, V24, P341, DOI 10.1042/bst0240341
   Hales CN, 2001, LANCET, V357, P136, DOI 10.1016/S0140-6736(00)03553-4
   IWASAKI K, 1988, J GERONTOL, V43, pB5, DOI 10.1093/geronj/43.1.B5
   Jennings BJ, 1999, FEBS LETT, V448, P4, DOI 10.1016/S0014-5793(99)00336-1
   Jennings BJ, 2000, MOL GENET METAB, V71, P32, DOI 10.1006/mgme.2000.3077
   Krook A, 2000, DIABETES, V49, P284, DOI 10.2337/diabetes.49.2.284
   LANGE TV, 1998, SCIENCE, V279, P334
   Langley-Evans SC, 2000, INT J FOOD SCI NUTR, V51, P11, DOI 10.1080/096374800100859
   LangleyEvans SC, 1996, COMP BIOCHEM PHYS A, V114, P327, DOI 10.1016/0300-9629(96)00018-7
   Lewis RM, 2001, METABOLISM, V50, P562, DOI 10.1053/meta.2001.22516
   Lewis RM, 2002, BRIT J NUTR, V88, P283, DOI 10.1079/BJN2002656
   Lewis RM, 2001, BRIT J NUTR, V85, P193, DOI 10.1079/BJN2000247
   Maianu L, 2001, J CLIN ENDOCR METAB, V86, P5450, DOI 10.1210/jc.86.11.5450
   MEYNE J, 1989, P NATL ACAD SCI USA, V86, P7049, DOI 10.1073/pnas.86.18.7049
   Montgomery SM, 2002, BRIT MED J, V324, P26, DOI 10.1136/bmj.324.7328.26
   MOUKAYED M, 2002, DIABETIC MED S2, V19, pA66
   MOUKAYED M, 2002, DIABETIC MED S2, V19, P1
   NEEL JV, 1962, AM J HUM GENET, V14, P353
   Nelson RG, 1999, DIABETOLOGIA, V42, P90, DOI 10.1007/s001250051118
   Oikawa S, 1999, FEBS LETT, V453, P365, DOI 10.1016/S0014-5793(99)00748-6
   OSCAI LB, 1978, AM J PHYSIOL, V235, pR141, DOI 10.1152/ajpregu.1978.235.3.R141
   Ozanne SE, 1996, AM J PHYSIOL-ENDOC M, V271, pE1128, DOI 10.1152/ajpendo.1996.271.6.E1128
   Ozanne SE, 1999, J ENDOCRINOL, V162, P313, DOI 10.1677/joe.0.1620313
   Ozanne SE, 1998, METABOLISM, V47, P1450, DOI 10.1016/S0026-0495(98)90068-3
   Ozanne SE, 2001, BRIT MED BULL, V60, P143, DOI 10.1093/bmb/60.1.143
   Ozanne SE, 1997, AM J PHYSIOL-ENDOC M, V273, pE46, DOI 10.1152/ajpendo.1997.273.1.E46
   Ozanne SE, 2003, J ENDOCRINOL, V177, P235, DOI 10.1677/joe.0.1770235
   Ozanne SE, 1996, AM J PHYSIOL-ENDOC M, V270, pE559, DOI 10.1152/ajpendo.1996.270.4.E559
   Ozanne SE, 2001, AM J PHYSIOL-ENDOC M, V280, pE534, DOI 10.1152/ajpendo.2001.280.3.E534
   OZANNE SE, 2002, DIABETIC MED S2, V19, pP261
   OZANNE SE, 2002, DIABETES S2, V52, pP1199
   OZANNE SE, 1998, DIABET REV INT, V7, P5
   OZANNE SE, 2000, FETAL ORIGINS CARDIO, P161
   Petry C J, 2001, Int J Exp Diabetes Res, V2, P139
   Petry CJ, 1997, CLIN SCI, V93, P147, DOI 10.1042/cs0930147
   Petry CJ, 2000, DIABETIC MED, V17, P848, DOI 10.1046/j.1464-5491.2000.00392.x
   PHILLIPS DIW, 1994, DIABETOLOGIA, V37, P150, DOI 10.1007/s001250050086
   Poulsen P, 1997, DIABETOLOGIA, V40, P439, DOI 10.1007/s001250050698
   Ravelli ACJ, 1998, LANCET, V351, P173, DOI 10.1016/S0140-6736(97)07244-9
   Scaglia L, 1997, ENDOCRINOLOGY, V138, P1736, DOI 10.1210/en.138.4.1736
   Shepherd PR, 1997, BRIT J NUTR, V78, P121, DOI 10.1079/BJN19970124
   Singh Nalini, 2002, Journal of Cardiovascular Pharmacology and Therapeutics, V7, P117, DOI 10.1177/107424840200700208
   SNOECK A, 1990, BIOL NEONATE, V57, P107, DOI 10.1159/000243170
   Stanner SA, 1997, BMJ-BRIT MED J, V315, P1342, DOI 10.1136/bmj.315.7119.1342
   SYMONDS ME, 1992, J PHYSIOL-LONDON, V455, P487, DOI 10.1113/jphysiol.1992.sp019313
   ZGLINICKI TV, 1995, EXP CELL RES, V220, P186
NR 64
TC 108
Z9 126
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD JUL
PY 2003
VL 46
IS 7
BP 1013
EP 1019
DI 10.1007/s00125-003-1131-7
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 709VB
UT WOS:000184644300019
PM 12827239
OA Bronze
DA 2025-06-11
ER

PT J
AU Scherer, T
   Buettner, C
AF Scherer, Thomas
   Buettner, Christoph
TI The dysregulation of the endocannabinoid system in diabesity-a tricky
   problem
SO JOURNAL OF MOLECULAR MEDICINE-JMM
LA English
DT Review
DE Endocannabinoids; Leptin action; Adipose tissue; Mediobasal
   hypothalamus; Fat metabolism
ID CB1 RECEPTOR ANTAGONIST; CARDIOMETABOLIC RISK-FACTORS; ADIPOSE-TISSUE;
   OVERWEIGHT PATIENTS; GLUCOSE-UPTAKE; BODY-WEIGHT; LEPTIN; DIET; INSULIN;
   FAT
AB Endocannabinoids (ECs) are small lipid mediators that play a critical role in energy metabolism. Human studies have shown that the EC tone in peripheral tissues positively correlates with increased adiposity. Furthermore, pharmacological inhibition of EC signaling results in weight loss in humans. However, the mechanisms that cause the dysregulation of the EC system in obesity are not well-understood. Since the clinical utility of currently available EC blockers is severely limited due to their side effects like depression and suicidal ideation that are caused by central effects, it is important to delineate the role of central and peripheral effects of EC signaling in regulating glucose and lipid metabolism.
C1 [Scherer, Thomas; Buettner, Christoph] Mt Sinai Sch Med, Dept Med & Neurosci, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai
RP Buettner, C (corresponding author), Mt Sinai Sch Med, Dept Med & Neurosci, 1 Gustave L Levy Pl,POB 1055, New York, NY 10029 USA.
EM christoph.buettner@mssm.edu
RI Buettner, Christoph/F-5793-2013
OI Scherer, Thomas/0000-0003-4980-706X
FU National Institutes of Health [DK074873]; European Foundation for the
   Study of Diabetes; American Diabetes Association
FX This work was supported by DK074873 to CB from the National Institutes
   of Health and a European Foundation for the Study of Diabetes grant to
   TS. We thank George Kunos for critically reading the manuscript. CB is
   the recipient of a Junior Faculty Award from the American Diabetes
   Association.
CR Addy C, 2008, CELL METAB, V7, P68, DOI 10.1016/j.cmet.2007.11.012
   Bartness TJ, 2005, P NUTR SOC, V64, P53, DOI 10.1079/PNS2004409
   Bellocchio L, 2008, J NEUROENDOCRINOL, V20, P130, DOI 10.1111/j.1365-2826.2008.01682.x
   Bensaid M, 2003, MOL PHARMACOL, V63, P908, DOI 10.1124/mol.63.4.908
   Berger A, 2001, P NATL ACAD SCI USA, V98, P6402, DOI 10.1073/pnas.101119098
   Blüher M, 2006, DIABETES, V55, P3053, DOI 10.2337/db06-0812
   Buettner C, 2008, NAT MED, V14, P667, DOI 10.1038/nm1775
   Buettner C, 2008, ENDOCRIN METAB CLIN, V37, P825, DOI 10.1016/j.ecl.2008.09.001
   Cota D, 2003, J CLIN INVEST, V112, P423, DOI 10.1172/JCI17725
   Côté M, 2007, INT J OBESITY, V31, P692, DOI 10.1038/sj.ijo.0803539
   D'Eon TM, 2008, DIABETES, V57, P1262, DOI 10.2337/db07-1186
   Despres JP, 2005, NEW ENGL J MED, V353, P2121, DOI 10.1056/NEJMoa044537
   Di Marzo V, 2009, DIABETOLOGIA, V52, P213, DOI 10.1007/s00125-008-1178-6
   Di Marzo V, 2001, NATURE, V410, P822, DOI 10.1038/35071088
   diMarzo V, 1996, BIOCHEM J, V316, P977, DOI 10.1042/bj3160977
   Engeli S, 2005, DIABETES, V54, P2838, DOI 10.2337/diabetes.54.10.2838
   Gonthier MP, 2007, OBESITY, V15, P837, DOI 10.1038/oby.2007.581
   HALAAS JL, 1995, SCIENCE, V269, P543, DOI 10.1126/science.7624777
   Liu YL, 2005, INT J OBESITY, V29, P183, DOI 10.1038/sj.ijo.0802847
   Malcher-Lopes R, 2006, J NEUROSCI, V26, P6643, DOI 10.1523/JNEUROSCI.5126-05.2006
   Matias I, 2008, MOL CELL ENDOCRINOL, V286, pS66, DOI 10.1016/j.mce.2008.01.026
   Matias I, 2006, J CLIN ENDOCR METAB, V91, P3171, DOI 10.1210/jc.2005-2679
   Motaghedi R, 2008, OBESITY, V16, P1727, DOI 10.1038/oby.2008.309
   Murdolo G, 2007, J ENDOCRINOL INVEST, V30, pRC17, DOI 10.1007/BF03347440
   Nogueiras R, 2008, DIABETES, V57, P2977, DOI 10.2337/db08-0161
   Osei-Hyiaman D, 2005, J CLIN INVEST, V115, P1298, DOI 10.1172/JCI200523057
   Osei-Hyiaman D, 2008, J CLIN INVEST, V118, P3160, DOI 10.1172/JCI34827
   Pacher P, 2006, PHARMACOL REV, V58, P389, DOI 10.1124/pr.58.3.2
   Pagano C, 2007, J CLIN ENDOCR METAB, V92, P4810, DOI 10.1210/jc.2007-0768
   PELLEYMOUNTER MA, 1995, SCIENCE, V269, P540, DOI 10.1126/science.7624776
   Pi-Sunyer F, 2006, JAMA-J AM MED ASSOC, V295, P761, DOI 10.1001/jama.295.7.761
   Poirier B, 2005, DIABETES OBES METAB, V7, P65, DOI 10.1111/j.1463-1326.2004.00374.x
   Roche R, 2006, HISTOCHEM CELL BIOL, V126, P177, DOI 10.1007/s00418-005-0127-4
   Scheen AJ, 2006, LANCET, V368, P1660, DOI 10.1016/S0140-6736(06)69571-8
   Shimabukuro M, 1997, P NATL ACAD SCI USA, V94, P4637, DOI 10.1073/pnas.94.9.4637
   Starowicz KM, 2008, OBESITY, V16, P553, DOI 10.1038/oby.2007.106
   Trillou CR, 2003, AM J PHYSIOL-REG I, V284, pR345, DOI 10.1152/ajpregu.00545.2002
   Trillou CR, 2004, INT J OBESITY, V28, P640, DOI 10.1038/sj.ijo.0802583
   Van Gaal LF, 2005, LANCET, V365, P1389, DOI 10.1016/S0140-6736(05)66374-X
   Varga K, 1998, FASEB J, V12, P1035, DOI 10.1096/fasebj.12.11.1035
   Wang ZW, 1999, BIOCHEM BIOPH RES CO, V260, P653, DOI 10.1006/bbrc.1999.0918
   WEIGLE DS, 1995, J CLIN INVEST, V96, P2065, DOI 10.1172/JCI118254
   Williams CM, 1999, PSYCHOPHARMACOLOGY, V143, P315, DOI 10.1007/s002130050953
NR 43
TC 24
Z9 26
U1 0
U2 0
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0946-2716
EI 1432-1440
J9 J MOL MED
JI J. Mol. Med.
PD JUL
PY 2009
VL 87
IS 7
BP 663
EP 668
DI 10.1007/s00109-009-0459-y
PG 6
WC Genetics & Heredity; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Research & Experimental Medicine
GA 462HH
UT WOS:000267341200002
PM 19290485
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sisson, SB
   Gibson, AE
   Short, K
   Gardner, AW
   Whited, T
   Robledo, C
   Thompson, DM
AF Sisson, Susan B.
   Gibson, Ashley E.
   Short, Kevin
   Gardner, Andrew W.
   Whited, Teresa
   Robledo, Candace
   Thompson, David M.
TI Light Activity Following a Meal and Postprandial Cardiometabolic Risk in
   Adolescents
SO PEDIATRIC EXERCISE SCIENCE
LA English
DT Article
ID ENDOTHELIAL FUNCTION; TRIACYLGLYCEROL CONCENTRATIONS;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; PUBERTAL CHANGES;
   NORMAL-WEIGHT; SITTING TIME; EXERCISE; FAT; SEDENTARY
AB The purpose of this study was to determine if light physical activity (LPA) minimizes the impairment of cardiometabolic risk factors following a typical meal in adolescents. Eighteen adolescents (50% male, 14.8 +/- 2.3 yrs) consumed a meal (32% fat, 14% protein, 53% carbohydrate), then completed a walking (1.5mph for 45 min of each hour) or sitting treatment for 3 hr in randomized order on separate days. Following the meal, HDL cholesterol declined 4.8% but remained higher during walking at 3 hr (42.1mg/dl +/- 9.3) than sitting (8.4% decline; 40.5mg/dL +/- 9.9; treatment x time interaction, p < .03). The 3-hr insulin was lower after walking (24.8 mu IU/ml +/- 33.4) than sitting (37.8 mu IU/ml +/- 34.7; treatment x time interaction, p < .0001). Triglycerides increased by similar to 40% above baseline at 1 and 2 hr, with higher values for walking (treatment x time interaction, p < .02). However by 3 hr, triglycerides were not different from baseline. Area under the curve (AUC) analyses were not significantly different between treatments for any outcomes. Although minor, LPA appears to mitigate the undesirable postprandial changes in HDL cholesterol and insulin but not triglycerides, following a typical meal in adolescents.
C1 [Sisson, Susan B.; Gibson, Ashley E.; Short, Kevin; Gardner, Andrew W.; Whited, Teresa; Robledo, Candace; Thompson, David M.] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA.
C3 University of Oklahoma System; University of Oklahoma Health Sciences
   Center
RP Sisson, SB (corresponding author), Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA.
RI Short, Kevin/AAC-2553-2020
OI Short, Kevin/0000-0001-6704-9587
FU University of Oklahoma Health Sciences Center Vice President of Research
   Seed Grant Program; University of Oklahoma Health Sciences Center
   General Clinical Research Center; National Center for Research
   Resources, National Institutes of Health [M01 RR14467]
FX This project was supported by the University of Oklahoma Health Sciences
   Center Vice President of Research Seed Grant Program awarded to Dr.
   Sisson. This project was partially supported by the University of
   Oklahoma Health Sciences Center General Clinical Research Center and by
   grant M01 RR14467 from the National Center for Research Resources,
   National Institutes of Health. We thank all the participants for
   volunteering their time in the completion of this study. We thank
   Elizabeth S. Ramey, MS, RD, who was integral in the coordination of
   study participations and data collection.
CR Ainsworth BE, 2000, MED SCI SPORT EXER, V32, pS498, DOI 10.1097/00005768-200009001-00009
   Anderson RA, 2001, ATHEROSCLEROSIS, V159, P9, DOI 10.1016/S0021-9150(01)00669-4
   Anderson RA, 2001, ATHEROSCLEROSIS, V154, P475, DOI 10.1016/S0021-9150(00)00499-8
   Aoi W, 2013, MED SCI SPORT EXER, V45, P245, DOI 10.1249/MSS.0b013e31826f3107
   Barrett LA, 2007, MED SCI SPORT EXER, V39, P116, DOI 10.1249/01.mss.0000240327.31276.18
   Bonetti PO, 2004, J AM COLL CARDIOL, V44, P2137, DOI 10.1016/j.jacc.2004.08.062
   Camhi SM, 2010, INT J PEDIATR OBES, V5, P122, DOI 10.3109/17477160903111763
   Crepinsek MK, 2009, J AM DIET ASSOC, V109, pS31, DOI 10.1016/j.jada.2008.10.061
   Dunstan DW, 2012, DIABETES CARE, V35, P976, DOI 10.2337/dc11-1931
   Gill JMR, 2003, J NUTR BIOCHEM, V14, P122, DOI 10.1016/S0955-2863(02)00275-9
   Gosmanov AR, 2010, AM J PHYSIOL-ENDOC M, V299, pE953, DOI 10.1152/ajpendo.00469.2010
   Graham TE, 2004, CAN J APPL PHYSIOL, V29, P781, DOI 10.1139/h04-051
   Hostmark AT, 2006, PREV MED, V42, P369, DOI 10.1016/j.ypmed.2005.10.001
   Katsanos CS, 2004, CLIN J SPORT MED, V14, P33, DOI 10.1097/00042752-200401000-00006
   Katsanos CS, 2004, J APPL PHYSIOL, V96, P181, DOI 10.1152/japplphysiol.00243.2003
   Katzmarzyk PT, 2009, MED SCI SPORT EXER, V41, P998, DOI 10.1249/MSS.0b013e3181930355
   Kolovou GD, 2011, CURR VASC PHARMACOL, V9, P258
   Lopez-Miranda J, 2007, BRIT J NUTR, V98, P458, DOI 10.1017/S000711450774268X
   MacEneaney OJ, 2009, EUR J APPL PHYSIOL, V106, P721, DOI 10.1007/s00421-009-1073-y
   Mahmud FH, 2008, J PEDIATR-US, V152, P557, DOI 10.1016/j.jpeds.2007.08.044
   MARSHALL WA, 1969, ARCH DIS CHILD, V44, P291, DOI 10.1136/adc.44.235.291
   MARSHALL WA, 1970, ARCH DIS CHILD, V45, P13, DOI 10.1136/adc.45.239.13
   Martínez-Gómez D, 2010, REV ESP CARDIOL, V63, P277, DOI 10.1016/S0300-8932(10)70086-5
   Miyashita M, 2008, INT J OBESITY, V32, P1271, DOI 10.1038/ijo.2008.73
   Nygaard H, 2009, APPL PHYSIOL NUTR ME, V34, P1087, DOI 10.1139/H09-110
   Padilla J, 2006, EUR J APPL PHYSIOL, V98, P256, DOI 10.1007/s00421-006-0272-z
   Pate RR, 2008, EXERC SPORT SCI REV, V36, P173, DOI 10.1097/JES.0b013e3181877d1a
   PATSCH JR, 1994, ATHEROSCLEROSIS, V110, pS23, DOI 10.1016/0021-9150(94)05372-P
   PATSCH JR, 1992, ARTERIOSCLER THROMB, V12, P1336, DOI 10.1161/01.ATV.12.11.1336
   Sardinha LB, 2008, DIABETES CARE, V31, P569, DOI 10.2337/dc07-1286
   Shiang K., SAS CALCULATIONS ARE
   Shimabukuro M, 2007, AM J CLIN NUTR, V86, P923, DOI 10.1093/ajcn/86.4.923
   Steele RM, 2009, AM J CLIN NUTR, V90, P1185, DOI 10.3945/ajcn.2009.28153
   Tierney ESS, 2009, J PEDIATR-US, V154, P901, DOI 10.1016/j.jpeds.2008.12.028
   Tolfrey K, 2008, MED SCI SPORT EXER, V40, P1049, DOI 10.1249/MSS.0b013e31816770fe
   Tolfrey K, 2012, EUR J APPL PHYSIOL, V112, P23, DOI 10.1007/s00421-011-1936-x
   Treuth MS, 2004, MED SCI SPORT EXER, V36, P198, DOI 10.1249/01.MSS.0000113666.98463.B0
   Tryggestad JB, 2012, INT J PEDIAT, V2012, DOI 10.1155/2012/607895
   Umpaichitra V, 2004, J PEDIATR ENDOCR MET, V17, P853
   van der Ploeg HP, 2012, ARCH INTERN MED, V172, P494, DOI 10.1001/archinternmed.2011.2174
NR 40
TC 8
Z9 9
U1 0
U2 7
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 0899-8493
EI 1543-2920
J9 PEDIATR EXERC SCI
JI Pediatr. Exerc. Sci.
PD AUG
PY 2013
VL 25
IS 3
BP 347
EP 359
DI 10.1123/pes.25.3.347
PG 13
WC Pediatrics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Physiology; Sport Sciences
GA 218RA
UT WOS:000324448900004
PM 23501926
DA 2025-06-11
ER

PT J
AU Christopoulou, FD
   Kiortsis, DN
AF Christopoulou, F. D.
   Kiortsis, D. N.
TI An overview of the metabolic effects of rimonabant in randomized
   controlled trials: potential for other cannabinoid 1 receptor blockers
   in obesity
SO JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
LA English
DT Review
DE diabetes; dyslipidaemia; endocannabinoid system; metabolic effects;
   obesity; rimonabant
ID CARDIOMETABOLIC RISK-FACTORS; ENERGY-BALANCE; CARDIOVASCULAR-DISEASE;
   OVERWEIGHT PATIENTS; ABDOMINAL OBESITY; RIO-EUROPE; WEIGHT;
   DYSLIPIDEMIA; LEPTIN; METAANALYSIS
AB P>What is known and objective:
   Rimonabant, a cannabinoid receptor blocker, has recently been used in clinical practice for weight loss and weight maintenance. Our aim was to review the results of trials of the drug in relation to weight loss and maintenance, and its impact on cardio-metabolic risk factors.
   Methods:
   Randomized controlled trials with rimonabant were selected, through a Medline search, using the terms: rimonabant, endocannabinoid antagonist and obesity. Reports of studies on large numbers of patients and covering the topics related to this review were included.
   Results and Discussion:
   In all the trials, there was a considerable reduction in body weight in subjects taking 20 mg rimonabant daily varying from 2 center dot 6 to 6 center dot 3 kg (placebo-subtracted changes). Rimonabant was also associated with haemoglobin A(1c) (HbA(1c)) reduction. In the Rimonabant in obesity (RIO)-diabetes study, diabetic patients taking metformin or sulphonylureas showed decrease in HbA(1c) levels by 0 center dot 5-0 center dot 6 +/- 0 center dot 8% when rimonabant was added, whereas in the Serenade trial patients with untreated diabetes showed a reduction in HbA(1c) of 0 center dot 8% vs. 0 center dot 3% with placebo. Similar results were obtained in diabetic patients under insulin treatment. The lipidaemic profile also improved in patients taking rimonabant 20 mg daily; levels of high density lipoprotein cholesterol (HDL-c) increased significantly while levels of triglycerides (TRG) decreased in all trials, and positive effects were also observed in patients with atherogenic or untreated dyslipidaemia. In all the RIO studies, prevalence of the metabolic syndrome decreased significantly.
   In addition, patients treated with 20 mg rimonabant daily exhibited increase in adiponectin. The metabolic changes observed were partly independent of the weight loss and could be attributed to independent peripheral effect of rimonabant. All these beneficial metabolic effects of rimonabant could lead to progress in the prevention of cardiovascular disease.
   However, in all the trials the incidence of adverse events leading to discontinuation was greater in the rimonabant treated patients than placebo, mainly because of psychiatric disorders (depression and anxiety), nausea and dizziness.
   What is new and Conclusion:
   Rimonabant is effective in reducing weight in the obese but may lead to intolerable adverse effects most notably psychiatric effects, which make it unsuitable for routine use. However, the drug provides useful proof of principle for this approach to weight loss. Novel cannabinoid type 1 receptor blockers with selectivity for peripheral receptors, may achieve similar metabolic results with decreased prevalence of psychiatric adverse effects.
C1 [Christopoulou, F. D.; Kiortsis, D. N.] Univ Ioannina, Sch Med, Physiol Lab, GR-45110 Ioannina, Greece.
C3 University of Ioannina
RP Kiortsis, DN (corresponding author), Univ Ioannina, Sch Med, Physiol Lab, GR-45110 Ioannina, Greece.
EM dkiorts@cc.uoi.gr
OI CHRISTOPOULOU, FOTEINI/0000-0003-3626-3753
CR Bensaid M, 2003, MOL PHARMACOL, V63, P908, DOI 10.1124/mol.63.4.908
   Christensen R, 2007, LANCET, V370, P1706, DOI 10.1016/S0140-6736(07)61721-8
   Despres Jean-Pierre, 2007, Crit Pathw Cardiol, V6, P51, DOI 10.1097/HPC.0b013e318057d4c9
   Després JP, 2009, ARTERIOSCL THROM VAS, V29, P416, DOI 10.1161/ATVBAHA.108.176362
   Despres JP, 2005, NEW ENGL J MED, V353, P2121, DOI 10.1056/NEJMoa044537
   Di Marzo V, 2005, NAT NEUROSCI, V8, P585, DOI 10.1038/nn1457
   European Medicines Agency, 2008, EMEA5371532008
   Farooqi IS, 2008, NAT CLIN PRACT ENDOC, V4, P569, DOI 10.1038/ncpendmet0966
   GORDON DJ, 1989, CIRCULATION, V79, P8, DOI 10.1161/01.CIR.79.1.8
   Hedley AA, 2004, JAMA-J AM MED ASSOC, V291, P2847, DOI 10.1001/jama.291.23.2847
   Jakobsen MU, 2007, EPIDEMIOL REV, V29, P77, DOI 10.1093/epirev/mxm002
   James PT, 2004, EUR J CARDIOV PREV R, V11, P3, DOI 10.1097/01.hjr.0000114707.27531.48
   Jéquier E, 2002, ANN NY ACAD SCI, V967, P379, DOI 10.1111/j.1749-6632.2002.tb04293.x
   Klein S, 2004, CIRCULATION, V110, P2952, DOI 10.1161/01.CIR.0000145546.97738.1E
   Matias I, 2007, TRENDS ENDOCRIN MET, V18, P27, DOI 10.1016/j.tem.2006.11.006
   National Institute for Health and Clinical Excellence, 2006, CG43 OB FULL GUID 1
   Nissen SE, 2008, JAMA-J AM MED ASSOC, V299, P1547, DOI 10.1001/jama.299.13.1547
   Osei-Hyiaman D, 2006, INT J OBESITY, V30, pS33, DOI 10.1038/sj.ijo.0803276
   Osei-Hyiaman D, 2005, J CLIN INVEST, V115, P1298, DOI 10.1172/JCI200523057
   Pi-Sunyer F, 2006, JAMA-J AM MED ASSOC, V295, P761, DOI 10.1001/jama.295.7.761
   Priscilla A, 2008, 68 ADA SCI SESS SAN
   Ren J, 2004, J ENDOCRINOL, V181, P1, DOI 10.1677/joe.0.1810001
   Rosenstock J, 2007, DIABETES, V56, pA49
   Rucker D, 2007, BMJ-BRIT MED J, V335, P1194, DOI 10.1136/bmj.39385.413113.25
   Scheen AJ, 2006, LANCET, V368, P1660, DOI 10.1016/S0140-6736(06)69571-8
   Van Gaal LF, 2005, LANCET, V365, P1389, DOI 10.1016/S0140-6736(05)66374-X
   Van Gaal LF, 2008, EUR HEART J, V29, P1761, DOI 10.1093/eurheartj/ehn076
   *WHO, 2002, INT MAN CARD RISK RE
   York DA, 2004, CIRCULATION, V110, pE463, DOI 10.1161/01.CIR.0000140125.26161.49
NR 29
TC 86
Z9 94
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-4727
EI 1365-2710
J9 J CLIN PHARM THER
JI J. Clin. Pharm. Ther.
PD FEB
PY 2011
VL 36
IS 1
BP 10
EP 18
DI 10.1111/j.1365-2710.2010.01164.x
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 702FD
UT WOS:000285879100002
PM 21198716
OA gold
DA 2025-06-11
ER

PT J
AU Touati, S
   Meziri, F
   Devaux, S
   Berthelot, A
   Touyz, RM
   Laurant, P
AF Touati, Sabeur
   Meziri, Faycal
   Devaux, Sylvie
   Berthelot, Alain
   Touyz, Rhian M.
   Laurant, Pascal
TI Exercise Reverses Metabolic Syndrome in High-Fat Diet-Induced Obese Rats
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Article
DE ENDOTHELIUM; VESSEL; INSULIN; HYPERTENSION; Akt/eNOS PATHWAY
ID ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY;
   NITRIC-OXIDE; WEIGHT-LOSS; REDUCTION; RISK; MEN; HYPERTENSION;
   OVERWEIGHT
AB TOUATI, S., F. MEZIRI, S. DEVAUX, A. BERTHELOT, R. M. TOUYZ, and P. LAURANT. Exercise Reverses Metabolic Syndrome in High-Fat Diet-Induced Obese Rats. Med. Sci. Sports Exerc., Vol. 43, No. 3, pp. 398-407, 2011. Purpose: Chronic consumption of a high-fat diet induces obesity. We investigated whether exercise would reverse the cardiometabolic disorders associated with obesity without it being necessary to change from a high-to normal-fat diet. Methods: Sprague-Dawley rats were placed on a high-fat (HFD) or control diet (CD) for 12 wk. HFD rats were then divided into four groups: sedentary HFD (HFD-S), exercise trained (motor treadmill for 12 wk) HFD (HFD-Ex), modified diet (HFD to CD; HF/CD-S), and exercise trained with modified diet (HF/CD-Ex). Cardiovascular risk parameters associated with metabolic syndrome were measured, and contents of aortic Akt, phospho-Akt at Ser (473), total endothelial nitric oxide synthase (eNOS), and phospho-eNOS at Ser (1177) were determined by Western blotting. Results: Chronic consumption of HFD induced a metabolic syndrome. Exercise and dietary modifications reduced adiposity, improved glucose and insulin levels and plasma lipid profile, and exerted an antihypertensive effect. Exercise was more effective than dietary modification in improving plasma levels of thiobarbituric acid-reacting substance and in correcting the endothelium-dependent relaxation to acetylcholine and insulin. Furthermore, independent of the diet used, exercise increased Akt and eNOS phosphorylation. Conclusions: Metabolic syndrome induced by HFD is reversed by exercise and diet modification. It is demonstrated that exercise training induces these beneficial effects without the requirement for dietary modification, and these beneficial effects may be mediated by shear stress-induced Akt/eNOS pathway activation. Thus, exercise may be an effective strategy to reverse almost all the atherosclerotic risk factors linked to obesity, particularly in the vasculature.
C1 [Touati, Sabeur; Meziri, Faycal; Laurant, Pascal] UFR Sci, Avignon, France.
   [Touati, Sabeur; Meziri, Faycal; Touyz, Rhian M.] Univ Ottawa, Ottawa Hlth Res Inst, Kidney Res Ctr, Ottawa, ON, Canada.
   [Berthelot, Alain] Univ Franche Comte, F-25030 Besancon, France.
C3 University of Ottawa; Ottawa Hospital Research Institute; Universite de
   Franche-Comte
RP Touati, S (corresponding author), Pole Sportif & Rech Univ, Physiol & Physiopathol Adapat Cardiovasc & Exerci, 15 Blvd Limbert, F-84000 Avignon, France.
EM sabeur.touati@univ-avignon.fr
RI Touyz, Rhian/AAM-3564-2020
OI Touyz, Rhian/0000-0003-0670-0887; DEVAUX, Sylvie/0000-0003-4206-7580
CR Arvola P, 1999, CARDIOVASC RES, V43, P992, DOI 10.1016/S0008-6363(99)00141-8
   Barnard RJ, 1998, J APPL PHYSIOL, V84, P1311, DOI 10.1152/jappl.1998.84.4.1311
   BLAIR SN, 1995, JAMA-J AM MED ASSOC, V273, P1093, DOI 10.1001/jama.273.14.1093
   Cai H, 2000, CIRC RES, V87, P840, DOI 10.1161/01.RES.87.10.840
   Chen Hsiun-Ing, 1996, Journal of Biomedical Science, V3, P454, DOI 10.1007/BF02258049
   Davignon J, 2004, CIRCULATION, V109, P27, DOI 10.1161/01.CIR.0000131515.03336.f8
   De Glisezinski I, 1998, AM J PHYSIOL-ENDOC M, V275, pE951, DOI 10.1152/ajpendo.1998.275.6.E951
   Eckel RH, 1997, CIRCULATION, V96, P3248, DOI 10.1161/01.CIR.96.9.3248
   Franzoni F, 2005, AM J HYPERTENS, V18, P510, DOI 10.1016/j.amjhyper.2004.11.006
   Frisbee JC, 2006, AM J PHYSIOL-HEART C, V291, pH2483, DOI 10.1152/ajpheart.00566.2006
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Halverstadt A, 2007, METABOLISM, V56, P444, DOI 10.1016/j.metabol.2006.10.019
   Hambrecht R, 2003, CIRCULATION, V107, P3152, DOI 10.1161/01.CIR.0000074229.93804.5C
   Haslam DW, 2005, LANCET, V366, P1197, DOI 10.1016/S0140-6736(05)67483-1
   Ishikawa K, 1999, AM J CARDIOL, V84, P192, DOI 10.1016/S0002-9149(99)00233-7
   Jun HS, 2008, OBESITY, V16, P1226, DOI 10.1038/oby.2008.220
   Kim JY, 2000, AM J PHYSIOL-REG I, V279, pR2057, DOI 10.1152/ajpregu.2000.279.6.R2057
   Lind L, 1995, J HYPERTENS, V13, P1457
   Miller WC, 1999, MED SCI SPORT EXER, V31, P1129, DOI 10.1097/00005768-199908000-00008
   Mokdad AH, 2004, JAMA-J AM MED ASSOC, V291, P1238, DOI 10.1001/jama.291.10.1238
   Montagnani M, 2002, MOL ENDOCRINOL, V16, P1931, DOI 10.1210/me.2002-0074
   Pinheiro AR, 2007, NUTR METAB CARDIOVAS, V17, P365, DOI 10.1016/j.numecd.2006.01.009
   Plotnick GD, 1997, JAMA-J AM MED ASSOC, V278, P1682, DOI 10.1001/jama.278.20.1682
   Rackley C E, 2000, Cardiol Rev, V8, P124, DOI 10.1097/00045415-200008020-00010
   Roberts CK, 2006, J APPL PHYSIOL, V101, P1727, DOI 10.1152/japplphysiol.00345.2006
   Roberts CK, 2005, J APPL PHYSIOL, V98, P3, DOI 10.1152/japplphysiol.00852.2004
   Roberts CK, 2005, J APPL PHYSIOL, V98, P203, DOI 10.1152/japplphysiol.00463.2004
   Roberts CK, 2001, HYPERTENSION, V37, P1323, DOI 10.1161/01.HYP.37.5.1323
   Ross R, 2000, ANN INTERN MED, V133, P92, DOI 10.7326/0003-4819-133-2-200007180-00008
   Savage PD, 2003, AM HEART J, V146, P317, DOI 10.1016/S0002-8703(02)94706-X
   Sciacqua A, 2003, DIABETES CARE, V26, P1673, DOI 10.2337/diacare.26.6.1673
   Sinitskaya N, 2007, CLIN SCI, V113, P417, DOI 10.1042/CS20070182
   Siu PM, 2003, J APPL PHYSIOL, V94, P555, DOI 10.1152/japplphysiol.00821.2002
   Slentz CA, 2004, ARCH INTERN MED, V164, P31, DOI 10.1001/archinte.164.1.31
   Srere P.A., 1969, Methods in Enzymology, V13, P3, DOI DOI 10.1016/0076-6879(69)13005-0
   Steinberg HO, 1996, J CLIN INVEST, V97, P2601, DOI 10.1172/JCI118709
   Tjonna AE, 2008, CIRCULATION, V118, P346, DOI 10.1161/CIRCULATIONAHA.108.772822
   Touyz RM, 2003, J HYPERTENS, V21, P337, DOI 10.1097/00004872-200302000-00025
   Wei M, 1999, JAMA-J AM MED ASSOC, V282, P1547, DOI 10.1001/jama.282.16.1547
   Zeng GY, 2000, CIRCULATION, V101, P1539, DOI 10.1161/01.CIR.101.13.1539
NR 40
TC 61
Z9 72
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAR
PY 2011
VL 43
IS 3
BP 398
EP 407
DI 10.1249/MSS.0b013e3181eeb12d
PG 10
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA 722OL
UT WOS:000287443200004
PM 20631645
OA Bronze
DA 2025-06-11
ER

PT J
AU Benyoub, N
   Merzouk, H
   Merzouk, AS
   Ghorzi, H
AF Benyoub, Noreddine
   Merzouk, Hafida
   Merzouk, Amel Saidi
   Ghorzi, Hafeda
TI Changes in metabolic parameters in growing male rats exposed to 10% and
   30% sucrose drinking
SO NUTRITION CLINIQUE ET METABOLISME
LA English
DT Article
DE Adipose tissue; Lipases; Liver; Obesity; Oxidative stress; Rat; Sucrose
   drink
ID SWEETENED BEVERAGE CONSUMPTION; HEPATIC TRIGLYCERIDE LIPASE; TISSUE
   LIPOPROTEIN-LIPASE; AGE-RELATED-CHANGES; OXIDATIVE STRESS; CHILDHOOD
   OBESITY; ADIPOSE-TISSUE; SUGAR; YOUNG; DIETARY
AB Sucrose drink induced obesity and metabolic syndrome in human and animal models. However, age specific metabolic effects of sucrose beverages are not clear yet. The purpose of this study was then to investigate changes in plasma biochemical parameters, oxidative stress markers, as well as lipid and redox contents and lipolytic activities in insulin target organs (liver, adipose tissue) in sucrose drinking rats at 10% and 30% during one month (day 30) and three months (day 90). Our results emphasized that sucrose drink induced obesity, adipose tissue accumulation with hyperinsulinemia, hyperglycemia, hyperlipidemia, liver steatosis, alterations in lipases activities and oxidative stress. These metabolic alterations were worsened by the amount of sucrose in the drink (30% versus 10%). The changes were apparent in young rats at day 30 and persisted until adulthood at day 90. Adult rats presented more sucrose-induced metabolic abnormalities. In conclusion, sucrose drink induced an early increase in metabolic syndrome components. These data indicate the need of corrective nutritional intervention for young people and also for adults. (C) 2021 Societe francophone nutrition clinique et metabolisme (SFNCM). Published by Elsevier Masson SAS. All rights reserved.
C1 [Benyoub, Noreddine; Merzouk, Hafida; Merzouk, Amel Saidi; Ghorzi, Hafeda] Univ Abou Bekr Belkaid Tlemcen, Fac Nat & Life Sci Earth & Universe, Dept Biol, Lab Physiol Physiopathol & Biochem Nutr, Tilimsen 13000, Algeria.
C3 Universite Abou Bekr Belkaid
RP Merzouk, H (corresponding author), Univ Abou Bekr Belkaid Tlemcen, Fac Nat & Life Sci Earth & Universe, Dept Biol, Lab Physiol Physiopathol & Biochem Nutr, Tilimsen 13000, Algeria.
EM hatidamerzouk_2@hotmail.com
OI merzouk, hafida/0000-0001-5081-3358
FU National Ministry of Higher Education and Scientific Research
FX The present study was done with the financial support of theNational
   Ministry of Higher Education and Scientific Research.
CR Aeberli I, 2011, AM J CLIN NUTR, V94, P479, DOI 10.3945/ajcn.111.013540
   Andrade MC, 2018, INSIGHT ENZYME RES, V2, P1
   [Anonymous], 2018, Continuity and coordination of care: A practice brief to support implementation of the WHO framework on integrated people-centered health services
   Assy N, 2008, CAN J GASTROENTEROL, V22, P811, DOI 10.1155/2008/810961
   Bacha F, 2016, CURR DIABETES REP, V16, DOI 10.1007/s11892-016-0750-6
   Basciano Heather, 2005, Nutr Metab (Lond), V2, P5, DOI 10.1186/1743-7075-2-5
   Benkalfat NB, 2011, CLIN SCI, V121, P19, DOI 10.1042/CS20100534
   Braidy N, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019194
   Cabral T. M., 2018, Health, V10, P700, DOI 10.4236/health.2018.105054
   CARLILE SI, 1985, ARCH GERONTOL GERIAT, V4, P133, DOI 10.1016/0167-4943(85)90027-5
   Chan TF, 2014, NUTRIENTS, V6, P2088, DOI 10.3390/nu6052088
   Chia CW, 2018, CIRC RES, V123, P886, DOI 10.1161/CIRCRESAHA.118.312806
   Chong MFF, 2007, P NUTR SOC, V66, P52, DOI 10.1017/S0029665107005290
   Crescenzo R, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00411
   de Koning L, 2012, CIRCULATION, V125, P1735, DOI 10.1161/CIRCULATIONAHA.111.067017
   de Koning L, 2011, AM J CLIN NUTR, V93, P1321, DOI 10.3945/ajcn.110.007922
   DellaValle DM, 2005, APPETITE, V44, P187, DOI 10.1016/j.appet.2004.11.003
   Demerdash HM., 2017, Obes Res Open J, V4, P32, DOI DOI 10.17140/OROJ-4-131
   El Wakeel MA., 2018, Biosci Res, V15, P3803
   El-Terras A, 2016, MOL MED REP, V13, P3147, DOI 10.3892/mmr.2016.4903
   Eldeeb R, 2013, IOSR J PHARM, V3, P35
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Fischer IP, 2018, INT J OBESITY, V42, P507, DOI 10.1038/ijo.2017.224
   Fowler SP, 2008, OBESITY, V16, P1894, DOI 10.1038/oby.2008.284
   HOLM G, 1975, J LIPID RES, V16, P461
   Imessaoudene A, 2016, J NUTR BIOCHEM, V29, P107, DOI 10.1016/j.jnutbio.2015.11.011
   Kanazawa M, 2003, NUTR REV, V61, pS27, DOI 10.1301/nr.2003.may.S27-S33
   Keller A, 2015, CHILD OBES, V11, P338, DOI 10.1089/chi.2014.0117
   Kinlen D, 2018, QJM-INT J MED, V111, P437, DOI 10.1093/qjmed/hcx152
   Kobayashi J, 2015, J ATHEROSCLER THROMB, V22, P1001, DOI 10.5551/jat.31617
   Kopprasch S, 2016, CLIN ENDOCRINOL, V84, P48, DOI 10.1111/cen.12811
   Kosova EC, 2013, J ACAD NUTR DIET, V113, P219, DOI 10.1016/j.jand.2012.10.020
   Kusunoki M., 2012, Health, V4, P1405
   Lozano WM, 2019, ANIMALS-BASEL, V9, DOI 10.3390/ani9070463
   Ludwig DS, 2001, LANCET, V357, P505, DOI 10.1016/S0140-6736(00)04041-1
   Ma JT, 2016, CIRCULATION, V133, P370, DOI 10.1161/CIRCULATIONAHA.115.018704
   Makarem N, 2018, ANNU REV NUTR, V38, P17, DOI 10.1146/annurev-nutr-082117-051805
   Malik VS, 2010, CIRCULATION, V121, P1356, DOI 10.1161/CIRCULATIONAHA.109.876185
   Mancuso P, 2019, FRONT ENDOCRINOL, V10, DOI [10.3389/fendo.2019.00137, 10.3389/fendo.019.00137]
   Marseglia L, 2015, INT J MOL SCI, V16, P378, DOI 10.3390/ijms16010378
   Matsumoto R, 2019, LIPIDS HEALTH DIS, V18, DOI 10.1186/s12944-019-1014-7
   Paes VM, 2015, OBES REV, V16, P903, DOI 10.1111/obr.12310
   Pagliassotti Michael J., 1996, American Journal of Physiology, V271, pR1319
   Pan A, 2011, CURR OPIN CLIN NUTR, V14, P385, DOI 10.1097/MCO.0b013e328346df36
   Rehman A, 2018, INT J ADV RES, V6, P1170
   Rehman K, 2016, J BIOMED SCI, V23, DOI 10.1186/s12929-016-0303-y
   Reid M, 2007, BRIT J NUTR, V97, P193, DOI 10.1017/S0007114507252705
   Rikans LE, 1997, BBA-MOL BASIS DIS, V1362, P116, DOI 10.1016/S0925-4439(97)00067-7
   Saku K, 1996, ARTERY, V22, P36
   Sies H, 2005, J NUTR, V135, P969, DOI 10.1093/jn/135.5.969
   Simmonds M, 2016, OBES REV, V17, P95, DOI 10.1111/obr.12334
   Spinelli A, 2019, OBESITY FACTS, V12, P244, DOI 10.1159/000500436
   Tabet F, 2009, CLIN SCI, V116, P87, DOI 10.1042/CS20080106
   Tan BL, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/9719584
   Vincent HK, 2006, INT J OBESITY, V30, P400, DOI 10.1038/sj.ijo.0803177
   Wang H, 2009, AM J PHYSIOL-ENDOC M, V297, pE271, DOI 10.1152/ajpendo.90920.2008
   Wree A, 2011, DIGESTION, V83, P124, DOI 10.1159/000318741
   Yang Qing, 2010, Yale Journal of Biology and Medicine, V83, P101
   Yost TJ, 1998, AM J CLIN NUTR, V68, P296, DOI 10.1093/ajcn/68.2.296
   Zechner R, 2000, INT J OBESITY, V24, pS53, DOI 10.1038/sj.ijo.0801506
   Zhao S, 2008, J ANIM PHYSIOL AN N, V92, P105, DOI 10.1111/j.1439-0396.2007.00723.x
NR 61
TC 0
Z9 0
U1 0
U2 2
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0985-0562
EI 1768-3092
J9 NUTR CLIN METAB
JI Nutr. Clin. Metab.
PD MAY
PY 2021
VL 35
IS 2
BP 129
EP 136
DI 10.1016/j.nupar.2020.11.002
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA SK9JP
UT WOS:000656535300005
DA 2025-06-11
ER

PT J
AU Zacarias, AC
   Barbosa, MA
   Guerra-Sá, R
   De Castro, UGM
   Bezerra, FS
   de Lima, WG
   Cardoso, LM
   dos Santos, RAS
   Campagnole-Santos, MJ
   Alzamora, AC
AF Zacarias, Aline Cruz
   Barbosa, Maria Andrea
   Guerra-Sa, Renata
   Mendes De Castro, Uberdan Guilherme
   Bezerra, Frank Silva
   de Lima, Wanderson Geraldo
   Cardoso, Leonardo M.
   Souza dos Santos, Robson Augusto
   Campagnole-Santos, Maria Jose
   Alzamora, Andreia Carvalho
TI Swimming training induces liver adaptations to oxidative stress and
   insulin sensitivity in rats submitted to high-fat diet
SO REDOX REPORT
LA English
DT Article
DE Physical training; oxidative stress; insulin signaling pathway; high-fat
   diet; liver
ID METABOLIC SYNDROME; PHYSICAL-ACTIVITY; GENE-EXPRESSION; ADIPOSE-TISSUE;
   EXERCISE; ANTIOXIDANT; RESISTANCE; CATALASE; DEFENSE
AB Oxidative stress, physical inactivity and high-fat (FAT) diets are associated with hepatic disorders such as metabolic syndrome (MS). The therapeutic effects of physical training (PT) were evaluated in rats with MS induced by FAT diet for 13 weeks, on oxidative stress and insulin signaling in the liver, during the last 6 weeks. FAT-sedentary (SED) rats increased body mass, retroperitoneal fat, mean arterial pressure (MAP) and heart rate (HR), and total cholesterol, serum alanine aminotransferase, glucose and insulin. Livers of FAT-SED rats increased superoxide dismutase activity, thiobarbituric acid-reactive substances, protein carbonyl and oxidized glutathione (GSSG); and decreased catalase activity, reduced glutathione/GSSG ratio, and the mRNA expression of insulin receptor substrate 1 (IRS-1) and serine/threonine kinase 2. FAT-PT rats improved in fitness and reduced their body mass, retroperitoneal fat, and glucose, insulin, total cholesterol, MAP and HR; and their livers increased superoxide dismutase and catalase activities, the reduced glutathione/GSSG ratio and the expression of peroxisome proliferator-activated receptor gamma and insulin receptor compared to FAT-SED rats. These findings indicated adaptive responses to PT by restoring the oxidative balance and insulin signaling in the liver and certain biometric and biochemical parameters as well as MAP in MS rats.
C1 [Guerra-Sa, Renata; Bezerra, Frank Silva; de Lima, Wanderson Geraldo; Cardoso, Leonardo M.; Alzamora, Andreia Carvalho] Univ Fed Ouro Preto, Inst Ciencias Exatas & Biol, Dept Ciencias Biol, Ouro Preto, MG, Brazil.
   [Zacarias, Aline Cruz; Barbosa, Maria Andrea; Guerra-Sa, Renata; Mendes De Castro, Uberdan Guilherme; Bezerra, Frank Silva; de Lima, Wanderson Geraldo; Cardoso, Leonardo M.; Alzamora, Andreia Carvalho] Univ Fed Ouro Preto, Nucleo Pesquisa Ciencias Biol, Ouro Preto, MG, Brazil.
   [Barbosa, Maria Andrea; Alzamora, Andreia Carvalho] Univ Fed Ouro Preto, Programa Posgrad Saude & Nutr, Ouro Preto, MG, Brazil.
   [Souza dos Santos, Robson Augusto; Campagnole-Santos, Maria Jose] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Fisiol & Biofis, Belo Horizonte, MG, Brazil.
C3 Universidade Federal de Ouro Preto; Universidade Federal de Ouro Preto;
   Universidade Federal de Ouro Preto; Universidade Federal de Minas Gerais
RP Alzamora, AC (corresponding author), Univ Fed Ouro Preto, Dept Ciencias Biol, Morro Cruzeiro 35, BR-400000 Ouro Preto, MG, Brazil.
EM andreiaalzamora@iceb.ufop.br
RI Santos, Robson/C-9336-2011; Campagnole-Santos, Maria/AAK-7515-2020;
   Cardoso, Leonardo/AAF-6516-2019; Bezerra, Frank/AAD-1233-2019; Lima,
   Wanderson/Y-7198-2019; Campagnole-Santos, Maria/F-5590-2017
OI Bezerra, Frank/0000-0002-0804-5196; Cardoso,
   Leonardo/0000-0001-9821-0484; Zacarias, Aline Cruz/0000-0002-2574-1775;
   Campagnole-Santos, Maria/0000-0001-9483-4206; Santos,
   Robson/0000-0001-8738-5852; Lima, Wanderson/0000-0001-9844-3472
FU Universidade Federal de Ouro Preto (UFOP); Pro-Reitoria de Pos-Graduacao
   (PROPP-UFOP); FAPEMIG (Fundacao de Amparo a Pesquisa do Estado de Minas
   Gerais)-Rede Toxifar [APQ-3384-3.13/07]; CNPq (Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico) [Universal472497/2013-8];
   FAPEMIG-Universal and Pronex Project Grant (FAPEMIG/CNPq)
FX This study was supported by the Universidade Federal de Ouro Preto
   (UFOP), Pro-Reitoria de Pos-Graduacao (PROPP-UFOP), FAPEMIG (Fundacao de
   Amparo a Pesquisa do Estado de Minas Gerais)-Rede Toxifar, CNPq
   (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico),
   FAPEMIG-Universal and Pronex Project Grant (FAPEMIG/CNPq). Aline Cruz
   Zacarias is a Master's Degree student in the Programa de Pos-graduacao
   Ciencias Biologicas, NUPEB, UFOP; CNPq: [Grant Number
   Universal472497/2013-8]; FAPEMIG: [Grant Number APQ-3384-3.13/07].
CR AEBI H, 1984, METHOD ENZYMOL, V105, P121
   Akerboom T P, 1981, Methods Enzymol, V77, P373
   Bandeira ACB, 2017, BIOORGAN MED CHEM, V25, P1057, DOI 10.1016/j.bmc.2016.12.018
   Botezelli JD, 2011, DIABETOL METAB SYNDR, V3, DOI 10.1186/1758-5996-3-35
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Brandt C, 2010, J BIOMED BIOTECHNOL, DOI 10.1155/2010/520258
   Caponi PW, 2013, CLINICS, V68, P1010, DOI 10.6061/clinics/2013(07)20
   Dalle Grave R, 2011, J OBES, V2011, DOI 10.1155/2011/348293
   de Farias JM, 2013, HORM METAB RES, V45, P190, DOI 10.1055/s-0032-1323740
   Dieterich S, 2000, CIRCULATION, V101, P33, DOI 10.1161/01.CIR.101.1.33
   DRAPER HH, 1993, FREE RADICAL BIO MED, V15, P353, DOI 10.1016/0891-5849(93)90035-S
   Evans JL, 2005, ANTIOXID REDOX SIGN, V7, P1040, DOI 10.1089/ars.2005.7.1040
   GEORGE V, 1990, INT J OBESITY, V14, P1085
   Golbidi S, 2012, EXP DIABETES RES, DOI 10.1155/2012/941868
   Hwang YC, 2015, INT J OBESITY, V39, P1365, DOI 10.1038/ijo.2015.75
   Jin JL, 2010, AGING CELL, V9, P895, DOI 10.1111/j.1474-9726.2010.00617.x
   Johnson NA, 2010, HEPATOLOGY, V52, P370, DOI 10.1002/hep.23711
   Karim S, 2012, BMC GENOMICS, V13, DOI 10.1186/1471-2164-13-S6-S10
   Kiraly MA, 2005, INT J PSYCHIAT MED, V35, P75, DOI 10.2190/HX7L-4B40-PQNY-2A4P
   Korivi M, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/932165
   Lazarevic G, 2006, DIABETES METAB, V32, P583, DOI 10.1016/S1262-3636(07)70312-9
   LEVINE RL, 1990, METHOD ENZYMOL, V186, P464
   Lima FD, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055668
   Liu JK, 2000, J APPL PHYSIOL, V89, P21
   Liu Y, 2015, J PHYS THER SCI, V27, P2365, DOI 10.1589/jpts.27.2365
   Luquet S, 2005, BBA-MOL BASIS DIS, V1740, P313, DOI 10.1016/j.bbadis.2004.11.011
   Machado MV, 2014, METAB SYNDR RELAT D, V12, P484, DOI 10.1089/met.2014.0040
   Maia RCA, 2015, BRAZ J MED BIOL RES, V48, P1010, DOI [10.1590/1414-431X20154499, 10.1590/1414-431x20154499]
   Marcinko K, 2015, MOL METAB, V4, P903, DOI 10.1016/j.molmet.2015.09.006
   Mastorakos G, 2005, HORM METAB RES, V37, P577, DOI 10.1055/s-2005-870426
   de Castro UGM, 2013, LIPIDS HEALTH DIS, V12, DOI 10.1186/1476-511X-12-136
   Morvan E, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-89
   Mostarda C, 2012, CLINICS, V67, P815
   Navarro A, 2004, AM J PHYSIOL-REG I, V286, pR505, DOI 10.1152/ajpregu.00208.2003
   Okuno Y, 2010, ENDOCR J, V57, P303, DOI 10.1507/endocrj.K09E-113
   REEVES PG, 1993, J NUTR, V123, P1939, DOI 10.1093/jn/123.11.1939
   Rodrigues MC, 2007, PEPTIDES, V28, P1375, DOI 10.1016/j.peptides.2007.06.001
   Salonen MK, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0126737
   Sanders RA, 2001, J BIOCHEM MOL TOXIC, V15, P143, DOI 10.1002/jbt.11
   Soares ER, 2011, BRAZ J MED BIOL RES, V44, P573, DOI 10.1590/S0100-879X2011007500049
   Sousa LE, 2015, FREE RADICAL RES, V49, P1335, DOI 10.3109/10715762.2015.1069291
   Sun LJ, 2010, LIFE SCI, V86, P39, DOI 10.1016/j.lfs.2009.11.003
   Tsuda M, 2000, EUR J PEDIATR, V159, P867, DOI 10.1007/s004310000600
   TUCKER LA, 1992, AM J CLIN NUTR, V56, P616, DOI 10.1093/ajcn/56.4.616
   Voltarelli FA, 2002, BRAZ J MED BIOL RES, V35, P1389, DOI 10.1590/S0100-879X2002001100018
   Vukovic R, 2014, CROAT MED J, V55, P218, DOI 10.3325/cmj.2014.55.218
   Wilson DO, 2000, J APPL PHYSIOL, V88, P1791, DOI 10.1152/jappl.2000.88.5.1791
NR 47
TC 13
Z9 14
U1 0
U2 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1351-0002
EI 1743-2928
J9 REDOX REP
JI Redox Rep.
PY 2017
VL 22
IS 6
BP 515
EP 523
DI 10.1080/13510002.2017.1315513
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA FL2KP
UT WOS:000414044500035
PM 28403686
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Casagrande, BP
   Estadella, D
AF Casagrande, Breno P.
   Estadella, Debora
TI Withdrawing from obesogenic diets: benefits and barriers in the short-
   and long-term in rodent models
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE behavior; metabolism; review; reward system; stress hormones
ID HIGH-FAT DIET; DEPRESSIVE-LIKE BEHAVIOR; ANXIETY-LIKE BEHAVIOR;
   METABOLIC SYNDROME; HIGH-CARBOHYDRATE; GENE-EXPRESSION; CAFETERIA DIET;
   GUT MICROBIOTA; PALATABLE DIET; EXPOSURE
AB There is accumulating evidence of dietary impact on several metabolic parameters. Unhealthy diets are estimated to be responsible for about 20% of the deaths worldwide. The recommendation is to improve the dietary pattern, aiming to prevent further harm. In this context. we reviewed the benefits and barriers of withdrawing from continuous obesogenic diet intake in the short- and long-term, which were found in rodent models. Although dietary modifications demand a re-establishment of the equilibrium, withdrawing was seen as a homeostatic insult and thus elicited several responses to protect the organism. In the short-term, withdrawal presented stressful and reward destimulating responses. The intake of obesogenic diets presented rewarding and stress destimulating responses. Whereas withdrawing in the long term ameliorated several biological functions and histopathologic features, it was not effective at reestablishing food intake and normalizing feeding behaviors or reward pathways. Altogether, terminating obesogenic diet intake does not immediately extinguish all negative consequences, and it even elicits brain behavioral and metabolic modifications. These modifications can hinder the maintenance of habits' change and prevent reaching the long-term benefits of diet improvement.
C1 [Casagrande, Breno P.; Estadella, Debora] Univ Fed Sao Paulo, Inst Hlth & Soc, Biosci Dept, Santos, SP, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP)
RP Estadella, D (corresponding author), Univ Fed Sao Paulo, Inst Hlth & Soc, Biosci Dept, Santos, SP, Brazil.
EM estadella.debora@gmail.com
RI Casagrande, Breno/Y-1442-2019; Estadella, Debora/G-5817-2012
OI Estadella, Debora/0000-0001-9853-3662; Picin Casagrande,
   Breno/0000-0001-9478-8262
FU "Sao Paulo Research Foundation" (FAPESP) [17/25420-3]; "Coordination for
   the Improvement of Higher Education Personnel" (CAPES Brazil) [001];
   Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [17/25420-3] Funding Source: FAPESP
FX This work was supported by "Coordination for the Improvement of Higher
   Education Personnel" (CAPES Brazil - Financial Code 001); and the "Sao
   Paulo Research Foundation" (FAPESP) under Grant no. 17/25420-3.
CR Afshin A, 2019, LANCET, V393, P1958, DOI 10.1016/S0140-6736(19)30041-8
   American Heart Association, 2014, J Am Pharm Assoc (2003), V54, pe3, DOI 10.1016/j.jacc.2013.11.004
   Arcego DM, 2020, APPETITE, V153, DOI 10.1016/j.appet.2020.104739
   Avena NM, 2008, NEUROSCI BIOBEHAV R, V32, P20, DOI 10.1016/j.neubiorev.2007.04.019
   Beilharz JE, 2016, BEHAV BRAIN RES, V306, P1, DOI 10.1016/j.bbr.2016.03.018
   Benetti CD, 2014, NUTR NEUROSCI, V17, P127, DOI 10.1179/1476830513Y.0000000077
   Bortolin RC, 2018, INT J OBESITY, V42, P525, DOI 10.1038/ijo.2017.225
   Carlin JL, 2016, NEUROSCIENCE, V326, P170, DOI 10.1016/j.neuroscience.2016.04.002
   Carlin J, 2013, OBESITY, V21, P2513, DOI 10.1002/oby.20374
   Blanco-Gandía MC, 2019, BEHAV BRAIN RES, V368, P72, DOI 10.1016/j.bbr.2019.04.005
   Casagrande BP, 2020, J ENDOCRINOL, V245, P369, DOI 10.1530/JOE-20-0073
   Coccurello R, 2018, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00271
   Das N, 2017, FOOD FUNCT, V8, P1577, DOI 10.1039/c6fo01326k
   Dias VT, 2019, PROG NEURO-PSYCHOPH, V92, P199, DOI 10.1016/j.pnpbp.2019.01.007
   Estadella D, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/137579
   Forray MI, 2004, BRAIN RES REV, V47, P145, DOI 10.1016/j.brainresrev.2004.07.011
   Hazarika A, 2017, NUTRITION, V38, P95, DOI 10.1016/j.nut.2017.01.005
   Hazarika A, 2016, NUTRITION, V32, P1081, DOI 10.1016/j.nut.2016.03.005
   Iemolo A, 2013, NEUROPSYCHOPHARMACOL, V38, P2456, DOI 10.1038/npp.2013.147
   Iemolo A, 2012, BEHAV PHARMACOL, V23, P593, DOI 10.1097/FBP.0b013e328357697f
   Kalita H, 2020, CAN J DIABETES, V44, P317, DOI 10.1016/j.jcjd.2019.10.001
   Kim DH, 2018, NEUROSCI LETT, V664, P38, DOI 10.1016/j.neulet.2017.11.008
   Kim S, 2018, NEUROPHARMACOLOGY, V130, P10, DOI 10.1016/j.neuropharm.2017.11.041
   Lalanza JF, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0085049
   Lancaster GI, 2018, CELL METAB, V27, P1096, DOI 10.1016/j.cmet.2018.03.014
   Li J, 2017, NEUROPHARMACOLOGY, V126, P108, DOI 10.1016/j.neuropharm.2017.08.035
   Li X, 2018, J NUTR SCI VITAMINOL, V64, P233, DOI 10.3177/jnsv.64.233
   Martire SI, 2014, BEHAV BRAIN RES, V265, P132, DOI 10.1016/j.bbr.2014.02.027
   Matikainen-Ankney BA, 2020, OBESITY, V28, P851, DOI 10.1002/oby.22758
   Medina-Remón A, 2018, CRIT REV FOOD SCI, V58, P262, DOI 10.1080/10408398.2016.1158690
   Milanesi LH, 2019, TOXICOL LETT, V308, P7, DOI 10.1016/j.toxlet.2019.03.009
   Morris MJ, 2015, NEUROSCI BIOBEHAV R, V58, P36, DOI 10.1016/j.neubiorev.2014.12.002
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Ong ZY, 2013, APPETITE, V65, P189, DOI 10.1016/j.appet.2013.01.014
   Pankevich DE, 2010, J NEUROSCI, V30, P16399, DOI 10.1523/JNEUROSCI.1955-10.2010
   Ribeiro-Carvalho A, 2011, BEHAV BRAIN RES, V221, P282, DOI 10.1016/j.bbr.2011.03.014
   Rinnankoski-Tuikka R, 2014, METABOLISM, V63, P1031, DOI 10.1016/j.metabol.2014.05.010
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Shang Y, 2017, LIPIDS, V52, P499, DOI 10.1007/s11745-017-4253-2
   Shao SS, 2014, ACTA PHARMACOL SIN, V35, P1411, DOI 10.1038/aps.2014.82
   Sharma S, 2013, INT J OBESITY, V37, P1183, DOI 10.1038/ijo.2012.197
   Soleymani T, 2016, OBES REV, V17, P81, DOI 10.1111/obr.12322
   South T, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0093506
   South T, 2012, PHYSIOL BEHAV, V105, P1052, DOI 10.1016/j.physbeh.2011.11.019
   Uriarte G, 2013, J PHYSIOL BIOCHEM, V69, P601, DOI 10.1007/s13105-012-0231-6
   Zamarron BF, 2017, DIABETES, V66, P392, DOI 10.2337/db16-0500
   Zemdegs J, 2016, BRIT J PHARMACOL, V173, P2095, DOI 10.1111/bph.13343
NR 47
TC 7
Z9 7
U1 0
U2 2
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD SEP
PY 2020
VL 319
IS 3
BP E485
EP E493
DI 10.1152/ajpendo.00174.2020
PG 9
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA NS6KW
UT WOS:000572368900003
PM 32663098
DA 2025-06-11
ER

PT J
AU Prasatthong, P
   Meephat, S
   Rattanakanokchai, S
   Bunbupha, S
   Prachaney, P
   Maneesai, P
   Pakdeechote, P
AF Prasatthong, Patoomporn
   Meephat, Sariya
   Rattanakanokchai, Siwayu
   Bunbupha, Sarawoot
   Prachaney, Parichat
   Maneesai, Putcharawipa
   Pakdeechote, Poungrat
TI Hesperidin ameliorates signs of the metabolic syndrome and cardiac
   dysfunction via IRS/Akt/GLUT4 signaling pathway in a rat model of
   diet-induced metabolic syndrome
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Hesperidin; Cardiac function; Cardiac insulin signaling pathway; p-IRS1;
   GLUT4; Metabolic syndrome
ID HIGH-FAT-DIET; INSULIN-RESISTANCE; GLUCOSYL HESPERIDIN; OXIDATIVE
   STRESS; MOUSE MODEL; METFORMIN; PRESSURE; ISCHEMIA; OBESITY; LIVER
AB Background Hesperidin has been reported to have biological activities such as antihypertensive, hypoglycemic, and antioxidant effects. This study investigated whether hesperidin could improve signs of the metabolic syndrome and cardiac function in a high-fat diet (HFD) induced metabolic syndrome (MS) in rats. Methods Male Sprague-Dawley rats were fed HFD and 15% fructose for 16 weeks and treated with hesperidin (15 or 30 mg/kg, based on signs of MS from a preliminary study) or metformin, a positive control agent, (100 mg/kg) for the final four weeks. Cardiac function, blood pressure, fasting blood glucose, oral glucose tolerance, serum insulin, and lipid profiles were measured. Histomorphometrics of left ventricles, epidydimal fat pads and liver were evaluated. Expressions of phosphorylate insulin receptor substrate1(p-IRS1), p-Akt and GLUT4 in cardiac tissue were determined. Results Hesperidin and metformin attenuated MS in HFD rats (p < 0.05). The accumulation of visceral fat pads and fatty liver associated with increases in liver lipid contents and liver enzymes were found in MS rats that were alleviated in hesperidin or metformin-treated groups (p < 0.05). Hesperidin and metformin improved cardiac dysfunction and hypertrophy observed in MS rats (p < 0.05). Restoration of the insulin signaling pathway, IRS/Akt/GLUT4 protein expression, was demonstrated in hesperidin and metformin-treated groups (p < 0.05). Hesperidin (30 mg/kg) was more effective than the lower dose. Conclusion Hesperidin was effective in reducing signs of MS and alterations of LV hypertrophy and function. These beneficial effects on the heart were associated with the restoration of the cardiac insulin signaling pathway in MS rats.
C1 [Prasatthong, Patoomporn; Meephat, Sariya; Maneesai, Putcharawipa; Pakdeechote, Poungrat] Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
   [Rattanakanokchai, Siwayu] Khon Kaen Univ, Fac Vet Med, Khon Kaen 40002, Thailand.
   [Bunbupha, Sarawoot] Mahasarakham Univ, Fac Med, Maha Sarakham 44000, Thailand.
   [Prachaney, Parichat] Khon Kaen Univ, Fac Med, Dept Anat, Khon Kaen 40002, Thailand.
C3 Khon Kaen University; Khon Kaen University; Mahasarakham University;
   Khon Kaen University
RP Pakdeechote, P (corresponding author), Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
EM ppoung@kku.ac.th
RI Maneesai, Putcharawipa/AAK-4258-2021
FU Graduate School, Invitation Research Fund [IN63119]; Cardiovascular
   Research Group, Khon Kaen University, Khon Kaen, Thailand;  [611JH216]
FX This study is financially supported by the Scholarship for Supporting
   Lecturer to Admit High Potential Student to Study and Research' on his
   expert program Year 2017 (Research No. 611JH216), Graduate School,
   Invitation Research Fund (IN63119) and Cardiovascular Research Group,
   Khon Kaen University, Khon Kaen, Thailand. We would like to acknowledge
   Prof. James A. Will, for editing the MS via Publication Clinic KKU,
   Thailand.
CR Akagiri S, 2008, J CLIN BIOCHEM NUTR, V42, P150, DOI 10.3164/jcbn.2008022
   Akiyama S, 2010, J CLIN BIOCHEM NUTR, V46, P87, DOI 10.3164/jcbn.09-82
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Bhargava P, 2019, J HYPERTENS, V37, pE183, DOI 10.1097/01.hjh.0000572356.32275.f4
   Brownsey RW, 1997, CARDIOVASC RES, V34, P3, DOI 10.1016/S0008-6363(97)00051-5
   Buettner R, 2006, J MOL ENDOCRINOL, V36, P485, DOI 10.1677/jme.1.01909
   Buettner R, 2007, OBESITY, V15, P798, DOI 10.1038/oby.2007.608
   Calle EE, 2004, NAT REV CANCER, V4, P579, DOI 10.1038/nrc1408
   Casacchia T, 2019, EUR J NUTR, V58, P965, DOI 10.1007/s00394-018-1609-1
   Corsale I, 2018, INT J COLORECTAL DIS, V33, P1595, DOI 10.1007/s00384-018-3102-y
   DiStefano JK, 2020, CELL MOL LIFE SCI, V77, P2079, DOI 10.1007/s00018-019-03390-0
   Efentakis P, 2019, BLOOD, V133, P710, DOI 10.1182/blood-2018-06-858415
   El Messaoudi S, 2011, CURR OPIN LIPIDOL, V22, P445, DOI 10.1097/MOL.0b013e32834ae1a7
   Fraulob JC, 2010, J CLIN BIOCHEM NUTR, V46, P212, DOI 10.3164/jcbn.09-83
   Gómez-Zorita S, 2017, J TRANSL MED, V15, DOI 10.1186/s12967-017-1343-0
   Gosslau A, 2018, FOOD SCI HUM WELL, V7, P244, DOI 10.1016/j.fshw.2018.10.001
   Granado M, 2019, NUTR METAB CARDIOVAS, V29, P97, DOI 10.1016/j.numecd.2018.09.005
   Grundy SM, 2016, TRENDS CARDIOVAS MED, V26, P364, DOI 10.1016/j.tcm.2015.10.004
   Guirro M, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9010079
   Huang JP, 2009, J BIOMED SCI, V16, DOI 10.1186/1423-0127-16-77
   Hussein AEM, 2011, CAN J PHYSIOL PHARM, V89, P216, DOI 10.1139/Y11-012
   Kalpana KB, 2009, MOL CELL BIOCHEM, V323, P21, DOI 10.1007/s11010-008-9960-9
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kirpichnikov D, 2002, ANN INTERN MED, V137, P25, DOI 10.7326/0003-4819-137-1-200207020-00009
   Kolter T, 1997, AM J PHYSIOL-ENDOC M, V273, pE59, DOI 10.1152/ajpendo.1997.273.1.E59
   Legtenberg RJ, 2002, HORM METAB RES, V34, P182, DOI 10.1055/s-2002-26705
   Liu HH, 2017, J CLIN BIOCHEM NUTR, V61, P85, DOI 10.3164/jcbn.16-98
   Mahmoud AM, 2012, J DIABETES COMPLICAT, V26, P483, DOI 10.1016/j.jdiacomp.2012.06.001
   Maneesai P, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1100-6
   Mayneris-Perxachs J, 2019, J FUNCT FOODS, V61, DOI 10.1016/j.jff.2019.103504
   Mosqueda-Solís A, 2018, J AGR FOOD CHEM, V66, P9679, DOI 10.1021/acs.jafc.8b02611
   Murakami K, 2004, CIRC J, V68, P650, DOI 10.1253/circj.68.650
   Nagai Y, 2002, AM J PHYSIOL-ENDOC M, V282, pE1180, DOI 10.1152/ajpendo.00471.2001
   Nascimento AR, 2013, OBESITY, V21, P2046, DOI 10.1002/oby.20358
   Nascimento FAM, 2010, EXP TOXICOL PATHOL, V62, P17, DOI 10.1016/j.etp.2008.12.008
   Nasri H, 2014, J RES MED SCI, V19, P658
   NEELY JR, 1976, CIRC RES, V38, P22
   Nemoto S, 2006, CIRC J, V70, P327, DOI 10.1253/circj.70.327
   Nizami HL, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201900109
   Ohtsuki K, 2002, J NUTR SCI VITAMINOL, V48, P420, DOI 10.3177/jnsv.48.420
   OPIE LH, 1976, CIRC RES, V38, P52
   Ouwens DM, 2007, DIABETOLOGIA, V50, P1938, DOI 10.1007/s00125-007-0735-8
   Pakdeechote P, 2014, NUTRIENTS, V6, P355, DOI 10.3390/nu6010355
   PATERNOSTRO G, 1995, CARDIOVASC RES, V30, P205, DOI 10.1016/0008-6363(95)00019-4
   Raher MJ, 2008, AM J PHYSIOL-HEART C, V295, pH2495, DOI 10.1152/ajpheart.00139.2008
   Reshidan NH, 2019, BMC COMPLEM ALTERN M, V19, DOI 10.1186/s12906-019-2627-0
   Simko F, 2002, MED HYPOTHESES, V58, P11, DOI 10.1054/mehy.2001.1399
   Suman R.K., 2016, Int. J. Biomed. Res., V7, P55
   TAI MM, 1994, DIABETES CARE, V17, P152, DOI 10.2337/diacare.17.2.152
   Verma S, 1999, EUR J PHARMACOL, V373, pR1, DOI 10.1016/S0014-2999(99)00301-5
   von Lewinski D, 2005, CIRCULATION, V111, P2588, DOI 10.1161/CIRCULATIONAHA.104.497461
   Wang L, 2015, BIOCHIMIE, V112, P129, DOI 10.1016/j.biochi.2015.02.024
   Watanabe S, 2018, J ATHEROSCLER THROMB, V25, P439, DOI 10.5551/jat.40956
   Wilcox Gisela, 2005, Clin Biochem Rev, V26, P19
   Wunpathe C, 2018, AM J CHINESE MED, V46, P751, DOI [10.1142/s0192415x18500398, 10.1142/S0192415X18500398]
   Yamamoto M, 2008, J NUTR SCI VITAMINOL, V54, P95, DOI 10.3177/jnsv.54.95
   Yeh CC, 2007, LIFE SCI, V80, P1821, DOI 10.1016/j.lfs.2007.01.052
   Yin MM, 2011, AM J PHYSIOL-HEART C, V301, pH459, DOI 10.1152/ajpheart.00054.2011
   Zayed EA, 2018, J BIOCHEM MOL TOXIC, V32, DOI 10.1002/jbt.22218
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI13505
NR 60
TC 24
Z9 29
U1 1
U2 13
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD MAR
PY 2021
VL 60
IS 2
BP 833
EP 848
DI 10.1007/s00394-020-02291-4
EA MAY 2020
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA QK8PU
UT WOS:000553644900001
PM 32462317
DA 2025-06-11
ER

PT J
AU Escudero-López, B
   Fernández-Pachón, MS
   Herrero-Martín, G
   Ortega, A
   Cerrillo, I
   Martín, F
   Berná, G
AF Escudero-Lopez, B.
   Fernandez-Pachon, M. S.
   Herrero-Martin, G.
   Ortega, A.
   Cerrillo, I.
   Martin, F.
   Berna, G.
TI Orange beverage ameliorates high-fat-diet-induced metabolic disorder in
   mice
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Fermented orange juice; Bioactive compounds; HFD; Metabolic syndrome;
   Antioxidant status; Lipid profile
ID ALCOHOLIC FERMENTATION; ANTIOXIDANT ACTIVITY; INFLAMMATORY MARKERS;
   OXIDATIVE STRESS; JUICE INTAKE; WEIGHT-GAIN; URIC-ACID; RED WINE;
   CONSUMPTION; LIVER
AB Metabolic syndrome (MetS) refers to a group of disorders that includes insulin resistance, central obesity, arterial hypertension and hyperlipidaemia. Regular consumption of bioactive compounds has consistently been associated with a reduced risk of these disorders. The aim of this study was to determine if an orange beverage with high concentrations of bioactive compounds (flavanones, carotenoids, melatonin, and ascorbic acid) and low alcohol content (<1%, v/v) improves metabolic parameters through modulation of oxidative stress, lipid profile and inflammatory response in a rodent model of high fat diet (HFD)-induced obesity. Mice with HFD-induced MetS were fed the orange beverage for 12 weeks (volume equivalent to 250 mL/day in human). Long-term intake of the orange beverage decreased plasma TAG, oxidized LDL and C-reactive protein levels. The present data provide evidence of a beneficial effect of orange beverage intake on some outcome parameters related to HFD-induced MetS. (c) 2016 Elsevier Ltd. All rights reserved.
C1 [Escudero-Lopez, B.; Fernandez-Pachon, M. S.; Herrero-Martin, G.; Ortega, A.; Cerrillo, I.; Martin, F.; Berna, G.] Univ Pablo Olavide, Dept Mol Biol & Biochem Engn, Area Nutr & Food Sci, ES-41013 Seville, Spain.
   [Fernandez-Pachon, M. S.; Cerrillo, I.] Univ Autonoma Chile, Fac Ciencias Salud, Av Pedro Valdivia 641, Santiago, Chile.
   [Ortega, A.; Martin, F.; Berna, G.] CIBERDEM Inst Salud Carlos III, CIBER Diabet Enfermedades Metabol Asociadas, Madrid 28029, Spain.
C3 Universidad Pablo de Olavide; Universidad Autonoma de Chile; CIBER -
   Centro de Investigacion Biomedica en Red; CIBERDEM
RP Berná, G (corresponding author), Univ Pablo Olavide, Genoveva Berna Amoros, Dept Biol Mol & Ingn Bioquim, Carretera Utrera Km 1, Seville 41013, Spain.
EM gberamo@upo.es
RI Fernández-Pachón, María-Soledad/GOE-5442-2022; Berna,
   Genoveva/AAG-7849-2020; Ortega, Angeles/ABA-8118-2020; Berna,
   Genoveva/K-4562-2014; Martin, Franz/K-4197-2014; Cerrillo Garcia,
   Isabel/K-1455-2016; Escudero-Lopez, Blanca/ABG-3957-2020
OI Berna, Genoveva/0000-0001-8185-8428; Fernandez-Pachon,
   Maria-Soledad/0000-0002-9524-298X; Martin, Franz/0000-0002-5745-8704;
   Ortega de la Torre, Maria de los Angeles/0000-0002-0503-5793; Cerrillo
   Garcia, Isabel/0000-0001-9068-8176; Escudero-Lopez,
   Blanca/0000-0002-4964-1306; Herrero Martin, Griselda/0000-0002-1120-8822
FU Junta de Andalucia; Ministerio de Ciencia e Innovacion [P09-AGR4814M,
   IPT-20111008]
FX We are grateful to Grupo Hesperides Biotech S.L. for providing samples
   of fermented orange juice. Authors are grateful for the support of the
   "Junta de Andalucia" and "Ministerio de Ciencia e Innovacion" through
   the Projects P09-AGR4814M and IPT-20111008 respectively. The Research
   Project grant of BEL is supported by the Junta de Andalucia. Authors
   belong to PAIDI Research Group BI0311 from Junta de Andalucia.
CR Agil A, 2013, J PINEAL RES, V54, P381, DOI 10.1111/jpi.12012
   Albert MA, 2003, CIRCULATION, V107, P443, DOI 10.1161/01.CIR.0000045669.16499.EC
   Alvarez-Parrilla E, 2010, INT J FOOD SCI NUTR, V61, P369, DOI 10.3109/09637480903514041
   Aptekmann NP, 2013, LIPIDS HEALTH DIS, V12, DOI 10.1186/1476-511X-12-119
   Athyros VG, 2007, ANGIOLOGY, V58, P689, DOI 10.1177/0003319707306146
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Brown T, 2009, OBES REV, V10, P627, DOI 10.1111/j.1467-789X.2009.00641.x
   Buege J A, 1978, Methods Enzymol, V52, P302
   Buettner R, 2007, OBESITY, V15, P798, DOI 10.1038/oby.2007.608
   Buscemi S, 2012, AM J CLIN NUTR, V95, P1089, DOI 10.3945/ajcn.111.031088
   Barquilla PC, 2014, J PINEAL RES, V57, P280, DOI 10.1111/jpi.12168
   CARMAGNOL F, 1983, BIOCHIM BIOPHYS ACTA, V759, P49, DOI 10.1016/0304-4165(83)90188-5
   Cerrillo I, 2014, J AGR FOOD CHEM, V62, P842, DOI 10.1021/jf404589b
   CHOI JS, 1991, J NAT PROD, V54, P218, DOI 10.1021/np50073a022
   CHOI JS, 1991, PLANTA MED, V57, P208, DOI 10.1055/s-2006-960075
   COHEN G, 1969, J BACTERIOL, V98, P543, DOI 10.1128/JB.98.2.543-546.1969
   CRIBB AE, 1989, ANAL BIOCHEM, V183, P195, DOI 10.1016/0003-2697(89)90188-7
   Daher CF, 2005, MED SCI MONITOR, V11, pBR465
   Dalgård C, 2009, BRIT J NUTR, V101, P263, DOI 10.1017/S0007114508995660
   Delgado-Andrade C, 2005, J AGR FOOD CHEM, V53, P7832, DOI 10.1021/jf0512353
   Demirtas CY, 2015, EUR REV MED PHARMACO, V19, P1915
   Escudero-López B, 2015, FOOD CHEM TOXICOL, V78, P78, DOI 10.1016/j.fct.2015.02.006
   Escudero-López B, 2013, J AGR FOOD CHEM, V61, P8773, DOI 10.1021/jf401240p
   Fernández-Pachón MS, 2014, J PINEAL RES, V56, P31, DOI 10.1111/jpi.12093
   Foroudi S, 2014, J MED FOOD, V17, P612, DOI 10.1089/jmf.2013.0034
   Fraulob JC, 2010, J CLIN BIOCHEM NUTR, V46, P212, DOI 10.3164/jcbn.09-83
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Gammone MA, 2015, FOOD NUTR RES, V59, DOI 10.3402/fnr.v59.26762
   Ghanim H, 2007, DIABETES CARE, V30, P1406, DOI 10.2337/dc06-1458
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Hutcheson R, 2012, EXP DIABETES RES, DOI 10.1155/2012/271028
   Imhof A, 2008, DIABETES VASC DIS RE, V5, P48, DOI 10.3132/dvdr.2008.009
   Innis SM, 2007, NUTR REV, V65, pS188, DOI [10.1111/j.1753-4887.2007.tb00361.x, 10.1301/nr.2007.dec.S188-S193]
   Kanbay M, 2016, EUR J INTERN MED, V29, P3, DOI 10.1016/j.ejim.2015.11.026
   Kurowska EM, 2000, AM J CLIN NUTR, V72, P1095
   Lebel M, 2010, ANN NY ACAD SCI, V1197, P40, DOI 10.1111/j.1749-6632.2010.05189.x
   Liu RH, 2013, ADV NUTR, V4, p384S, DOI 10.3945/an.112.003517
   Coelho RCLA, 2013, PLANT FOOD HUM NUTR, V68, P1, DOI 10.1007/s11130-013-0343-3
   MCCORD JM, 1969, J BIOL CHEM, V244, P6049
   Mena P, 2014, FOOD CHEM, V145, P327, DOI 10.1016/j.foodchem.2013.08.039
   Milagro FI, 2006, OBESITY, V14, P1118, DOI 10.1038/oby.2006.128
   Morand C, 2011, AM J CLIN NUTR, V93, P73, DOI 10.3945/ajcn.110.004945
   Ou BX, 2001, J AGR FOOD CHEM, V49, P4619, DOI 10.1021/jf010586o
   Pérez-Gregorio MR, 2011, LWT-FOOD SCI TECHNOL, V44, P1793, DOI 10.1016/j.lwt.2011.03.007
   Podrini C, 2013, MAMM GENOME, V24, P240, DOI 10.1007/s00335-013-9456-0
   Pu P, 2012, ARCH BIOCHEM BIOPHYS, V518, P61, DOI 10.1016/j.abb.2011.11.026
   Rangel-Huerta OD, 2015, J NUTR, V145, P1808, DOI 10.3945/jn.115.213660
   Rao MN, 2003, METABOLISM, V52, P1287, DOI 10.1016/S0026-0495(03)00191-4
   Reagan-Shaw S, 2008, FASEB J, V22, P659, DOI 10.1096/fj.07-9574LSF
   Rizza S, 2011, J CLIN ENDOCR METAB, V96, pE782, DOI 10.1210/jc.2010-2879
   Robinson K, 2011, CRIT CARE, V15, DOI 10.1186/cc10021
   Sánchez-Moreno C, 2003, AM J CLIN NUTR, V78, P454, DOI 10.1093/ajcn/78.3.454
   Shin JA, 2013, J DIABETES INVEST, V4, P334, DOI 10.1111/jdi.12075
   Stinco CM, 2012, J AGR FOOD CHEM, V60, P1447, DOI 10.1021/jf2043949
   Titta L, 2010, INT J OBESITY, V34, P578, DOI 10.1038/ijo.2009.266
   Torres A, 2015, REV CLIN ESP, V215, P486, DOI 10.1016/j.rce.2015.07.002
   Tounsi MS, 2011, J SCI FOOD AGR, V91, P142, DOI 10.1002/jsfa.4164
   Traversy G, 2015, CURR OBES REP, V4, P122, DOI 10.1007/s13679-014-0129-4
   Turner R C, 1990, Horm Metab Res Suppl, V24, P66
   Wang JC, 2012, BIOL TRACE ELEM RES, V146, P354, DOI 10.1007/s12011-011-9268-6
   Wilcox LJ, 2001, J LIPID RES, V42, P725
   Yu TY, 2016, METABOLISM, V65, P432, DOI 10.1016/j.metabol.2015.11.003
NR 63
TC 8
Z9 9
U1 0
U2 30
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JUN
PY 2016
VL 24
BP 254
EP 263
DI 10.1016/j.jff.2016.04.013
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA DP3BJ
UT WOS:000378367100025
DA 2025-06-11
ER

PT J
AU Calamita, G
   Portincasa, P
AF Calamita, Giuseppe
   Portincasa, Piero
TI Present and future therapeutic strategies in non-alcoholic fatty liver
   disease
SO EXPERT OPINION ON THERAPEUTIC TARGETS
LA English
DT Review
DE antioxidant; aquaglyceroporin; aquaporin; fatty liver; glitazone;
   insulin-resistance; liver steatosis; metabolic syndrome; oxidative
   stress; probiotic; sibutramine
ID RECEPTOR ANTAGONIST SR141716; PLACEBO-CONTROLLED TRIAL; ADIPOSE
   GENE-EXPRESSION; MORBIDLY OBESE-PATIENTS; ADENOSYL-L-METHIONINE;
   NECROSIS-FACTOR-ALPHA; VITAMIN-E TREATMENT; INSULIN-RESISTANCE;
   URSODEOXYCHOLIC ACID; HEPATIC STEATOSIS
AB Non-alcoholic fatty liver disease (NAFLD) is found in individuals who do not drink or abuse alcohol and represents a significant health burden for the general community. NAFLD is often associated with one or more features of the metabolic syndrome and has potential for evolution towards non-alcoholic steatohepatitis (NASH), the necro-inflammatory form of liver steatosis. The most worrisome evolutive events in a subgroup of NASH patients include advanced liver fibrosis, cirrhosis, and hepatocellular carcinoma. Pathophysiology of NAFLD/NASH is complex, but studies point to a pre-eminent role of oxidative stress and lipid peroxiclation in the liver, including early mitochondrial dysfunction. Changes follow an insulin resistance status with a background of a chronic pro-inflammatory status due to an excess of visceral adiposity. Although no established therapy exists for NAFLD/NASH, potential therapeutic approaches are discussed in this review.
C1 Univ Bari, Dept Gen & Environm Physiol, I-70121 Bari, Italy.
   Univ Bari, Clin Med A Murri, Dept Internal Med & Publ Med, I-70121 Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro
RP Portincasa, P (corresponding author), Univ Med Sch Bari, Clin Med A Murri, Dept Internal Med & Publ Med, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
EM p.portincasa@semeiotica.uniba.it
RI portincasa, piero/J-7245-2018
OI Calamita, Giuseppe/0000-0003-4666-9546; portincasa,
   piero/0000-0001-5359-1471
CR Abdelmalek MF, 2001, AM J GASTROENTEROL, V96, P2711
   Abiru S, 2006, LIVER INT, V26, P39, DOI 10.1111/j.1478-3231.2005.01191.x
   Adams LA, 2005, GASTROENTEROLOGY, V129, P113, DOI 10.1053/j.gastro.2005.04.014
   Adams LA, 2005, J HEPATOL, V42, P132, DOI 10.1016/j.jhep.2004.09.012
   Adams LA, 2004, AM J GASTROENTEROL, V99, P2365, DOI 10.1111/j.1572-0241.2004.40064.x
   Alwayn IPJ, 2005, TRANSPLANTATION, V79, P606, DOI 10.1097/01.TP.0000150023.86487.44
   Alwayn IPJ, 2005, PEDIATR RES, V57, P445, DOI 10.1203/01.PDR.0000153672.43030.75
   ANDERSEN T, 1991, J HEPATOL, V12, P224, DOI 10.1016/0168-8278(91)90942-5
   Angelico F, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005166.pub2
   [Anonymous], 2007, DIGEST DIS SCI
   Aubé C, 1999, J HEPATOL, V30, P472, DOI 10.1016/S0168-8278(99)80107-X
   Barzilai N, 1997, J CLIN INVEST, V100, P3105, DOI 10.1172/JCI119865
   Basaranoglu M, 1999, J HEPATOL, V31, P384, DOI 10.1016/S0168-8278(99)80243-8
   Bataller R, 2003, J CLIN INVEST, V112, P1383, DOI 10.1172/JCI200318212
   Beitz E, 1999, CURR MED CHEM, V6, P457
   Belfort R, 2006, NEW ENGL J MED, V355, P2297, DOI 10.1056/NEJMoa060326
   Bensaid M, 2003, MOL PHARMACOL, V63, P908, DOI 10.1124/mol.63.4.908
   BIANCHI G, 1994, HEPATOLOGY, V20, P119, DOI 10.1002/hep.1840200119
   Bookout AL, 2006, CELL, V126, P789, DOI 10.1016/j.cell.2006.06.049
   Boyd ST, 2005, ANN PHARMACOTHER, V39, P684, DOI 10.1345/aph.1E499
   Broughan TA, 1998, AM SURGEON, V64, P785
   Browning JD, 2004, J CLIN INVEST, V114, P147, DOI 10.1172/JCI200422422
   Buang Y, 2004, J NUTR SCI VITAMINOL, V50, P272, DOI 10.3177/jnsv.50.272
   Bugianesi E, 2005, AM J GASTROENTEROL, V100, P1082, DOI 10.1111/j.1572-0241.2005.41583.x
   Cai DS, 2005, NAT MED, V11, P183, DOI 10.1038/nm1166
   Caldwell SH, 2001, AM J GASTROENTEROL, V96, P519
   Callewaert N, 2004, NAT MED, V10, P429, DOI 10.1038/nm1006
   Canbay A, 2007, Z GASTROENTEROL, V45, P35, DOI 10.1055/s-2006-927368
   Capanni M, 2006, ALIMENT PHARM THER, V23, P1143, DOI 10.1111/j.1365-2036.2006.02885.x
   Caraceni P, 2005, J SURG RES, V127, P190, DOI 10.1016/j.jss.2005.02.018
   Carbrey JM, 2003, P NATL ACAD SCI USA, V100, P2945, DOI 10.1073/pnas.0437994100
   Chalasani N, 2005, HEPATOLOGY, V41, P690, DOI 10.1002/hep.20671
   Chiappini F, 2006, LAB INVEST, V86, P154, DOI 10.1038/labinvest.3700374
   Chitturi S, 2002, HEPATOLOGY, V35, P373, DOI 10.1053/jhep.2002.30692
   Chitturi S, 2001, SEMIN LIVER DIS, V21, P27, DOI 10.1055/s-2001-12927
   Choi S, 2005, CURR OPIN GASTROEN, V21, P702, DOI 10.1097/01.mog.0000182863.96421.47
   Contos MJ, 2001, LIVER TRANSPLANT, V7, P363, DOI 10.1053/jlts.2001.23011
   Cope K, 2000, GASTROENTEROLOGY, V119, P1340, DOI 10.1053/gast.2000.19267
   Cortez-Pinto H, 2006, J HEPATOL, V44, P197, DOI 10.1016/j.jhep.2005.09.002
   Cortez-Pinto H, 2003, DIGEST DIS SCI, V48, P1909, DOI 10.1023/A:1026152415917
   CURRY MP, 2007, UP TODATE, P1
   Dam-Larsen S, 2004, GUT, V53, P750, DOI 10.1136/gut.2003.019984
   DAVIES RJ, 1991, CLIN RADIOL, V43, P393, DOI 10.1016/S0009-9260(05)80567-7
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   Day CP, 2006, GASTROENTEROLOGY, V130, P207, DOI 10.1053/j.gastro.2005.11.017
   de Knegt RJ, 2001, SCAND J GASTROENTERO, V36, P88, DOI 10.1080/003655201753265505
   Despres JP, 2005, NEW ENGL J MED, V353, P2121, DOI 10.1056/NEJMoa044537
   Di Sario A, 2005, DIGEST LIVER DIS, V37, P869, DOI 10.1016/j.dld.2005.05.011
   Dixon JB, 2003, J HEPATOL, V39, P967, DOI 10.1016/S0168-8278(03)00459-8
   Dixon JB, 2004, HEPATOLOGY, V39, P1647, DOI 10.1002/hep.20251
   Dufour JF, 2006, CLIN GASTROENTEROL H, V4, P1537, DOI 10.1016/j.cgh.2006.09.025
   ENDO A, 1992, J LIPID RES, V33, P1569
   Enriquez A, 1999, BIOCHEM BIOPH RES CO, V255, P300, DOI 10.1006/bbrc.1999.0202
   Ersoz Galip, 2005, Turk J Gastroenterol, V16, P124
   Falck-Ytter Y, 2001, SEMIN LIVER DIS, V21, P17, DOI 10.1055/s-2001-12926
   Fan JG, 2005, J HEPATOL, V43, P508, DOI 10.1016/j.jhep.2005.02.042
   Fasshauer M, 2003, HORM METAB RES, V35, P222
   Fassio E, 2004, HEPATOLOGY, V40, P820, DOI 10.1002/hep.20410
   Federico A, 2006, GUT, V55, P901, DOI 10.1136/gut.2006.091967
   Feldstein AE, 2003, GASTROENTEROLOGY, V125, P437, DOI 10.1016/S0016-5085(03)00907-7
   Fernández MA, 2006, SCIENCE, V313, P1628, DOI 10.1126/science.1130773
   FERRANNINI E, 1983, J CLIN INVEST, V72, P1737, DOI 10.1172/JCI111133
   Filippatos TD, 2005, CURR MED RES OPIN, V21, P457, DOI 10.1185/030079905X38132
   Foucher J, 2006, GUT, V55, P403, DOI 10.1136/gut.2005.069153
   Frank PG, 2007, CELL CYCLE, V6, P115, DOI 10.4161/cc.6.2.3722
   Friedman JM, 1998, NATURE, V395, P763, DOI 10.1038/27376
   Friedmann S.J., 2007, UCRL-TR-234408: Site characterization and selection guidelines for geological carbon sequestration, P1
   Frühbeck G, 2006, TRENDS PHARMACOL SCI, V27, P345, DOI 10.1016/j.tips.2006.05.002
   Ganne-Carrié N, 2006, HEPATOLOGY, V44, P1511, DOI 10.1002/hep.21420
   GARRUTI G, 2007, OBES RES, V15
   Georgescu EF, 2007, J GASTROINTEST LIVER, V16, P39
   Gilat T, 2003, HEPATOLOGY, V38, P436, DOI 10.1053/jhep.2003.50348
   Gilat T, 2002, HEPATOLOGY, V35, P597, DOI 10.1053/jhep.2002.31868
   Grattagliano I, 2000, J NUTR, V130, P2131, DOI 10.1093/jn/130.9.2131
   Grundy SM, 2006, DIABETES CARE, V29, P1689, DOI 10.2337/dc05-2307
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Grundy SM, 2004, AM J CLIN NUTR, V80, P1
   Guallar E, 2005, ANN INTERN MED, V143, P143, DOI 10.7326/0003-4819-143-2-200507190-00014
   HALFON P, 2007, C J HEPATOL, V46, P395
   Hara-Chikuma M, 2006, CELL MOL LIFE SCI, V63, P1386, DOI 10.1007/s00018-006-6028-4
   Hara-Chikuma M, 2005, J BIOL CHEM, V280, P15493, DOI 10.1074/jbc.C500028200
   Harrison SA, 2004, ALIMENT PHARM THERAP, V20, P623, DOI 10.1111/j.1365-2036.2004.02153.x
   Harrison SA, 2003, AM J GASTROENTEROL, V98, P2485, DOI 10.1111/j.1572-0241.2003.08699.x
   Hasegawa T, 2001, ALIMENT PHARM THERAP, V15, P1667, DOI 10.1046/j.1365-2036.2001.01083.x
   Haslam DW, 2005, LANCET, V366, P1197, DOI 10.1016/S0140-6736(05)67483-1
   Hatzitolios Apostolos, 2004, Indian J Gastroenterol, V23, P131
   Hempfling W, 2003, ALIMENT PHARM THER, V18, P963, DOI 10.1046/j.1365-2036.2003.01792.x
   Hibuse T, 2005, P NATL ACAD SCI USA, V102, P10993, DOI 10.1073/pnas.0503291102
   Home PD, 2007, NEW ENGL J MED, V357, P28, DOI 10.1056/NEJMoa073394
   Imbert-Bismut F, 2001, LANCET, V357, P1069, DOI 10.1016/S0140-6736(00)04258-6
   James OFW, 1998, J HEPATOL, V29, P495, DOI 10.1016/S0168-8278(98)80073-1
   JENSEN MD, 1989, J CLIN INVEST, V83, P1168, DOI 10.1172/JCI113997
   Jeyaseelan K, 2006, EXPERT OPIN THER TAR, V10, P889, DOI 10.1517/14728222.10.6.889
   Joy D, 2003, EUR J GASTROEN HEPAT, V15, P539, DOI 10.1097/01.meg.0000059112.41030.2e
   Kahn BB, 2000, J CLIN INVEST, V106, P473, DOI 10.1172/JCI10842
   Kalaany NY, 2006, ANNU REV PHYSIOL, V68, P159, DOI 10.1146/annurev.physiol.68.033104.152158
   Kaneshiro Y, 1998, EUR SURG RES, V30, P34, DOI 10.1159/000008555
   Kettaneh A, 2007, J HEPATOL, V46, P628, DOI 10.1016/j.jhep.2006.11.010
   Kirpichnikov D, 2002, ANN INTERN MED, V137, P25, DOI 10.7326/0003-4819-137-1-200207020-00009
   Kishida K, 2001, J BIOL CHEM, V276, P48572, DOI 10.1074/jbc.M108213200
   Kishida K, 2001, J BIOL CHEM, V276, P36251, DOI 10.1074/jbc.M106040200
   Kiyici M, 2003, CAN J GASTROENTEROL, V17, P713, DOI 10.1155/2003/857869
   Klein S, 2006, GASTROENTEROLOGY, V130, P1564, DOI 10.1053/j.gastro.2006.01.042
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Koteish A, 2001, SEMIN LIVER DIS, V21, P89, DOI 10.1055/s-2001-12932
   Kugelmas M, 2003, HEPATOLOGY, V38, P413, DOI 10.1053/jhep.2003.50316
   Kuriyama H, 2002, DIABETES, V51, P2915, DOI 10.2337/diabetes.51.10.2915
   Kurtz TW, 2005, ACTA DIABETOL, V42, pS9, DOI 10.1007/s00592-005-0176-0
   Lainé F, 2004, HEPATOLOGY, V39, P1639, DOI 10.1002/hep.20219
   Larsson NG, 1995, ANNU REV GENET, V29, P151, DOI 10.1146/annurev.ge.29.120195.001055
   Laurin J, 1996, HEPATOLOGY, V23, P1464
   Lavine JE, 2000, J PEDIATR-US, V136, P734, DOI 10.1016/S0022-3476(00)05040-X
   Leclercq IA, 2000, BIOCHEM BIOPH RES CO, V268, P337, DOI 10.1006/bbrc.2000.2125
   Levy JR, 2004, HEPATOLOGY, V39, P608, DOI 10.1002/hep.20093
   Li ZP, 2003, HEPATOLOGY, V37, P343, DOI 10.1053/jhep.2003.50048
   Li ZP, 2005, ANN INTERN MED, V142, P532, DOI 10.7326/0003-4819-142-7-200504050-00012
   Liang RJ, 2007, OBES SURG, V17, P45, DOI 10.1007/s11695-007-9005-6
   Lin HZ, 2000, NAT MED, V6, P998, DOI 10.1038/79697
   Lindor KD, 2004, HEPATOLOGY, V39, P770, DOI 10.1002/hep.20092
   Lirussi F, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005165.pub2
   Lirussi F, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004996.pub3
   Liu YL, 2005, INT J OBESITY, V29, P183, DOI 10.1038/sj.ijo.0802847
   Loguercio C, 2005, J CLIN GASTROENTEROL, V39, P540, DOI 10.1097/01.mcg.0000165671.25272.0f
   Loguercio C, 2004, DIGEST LIVER DIS, V36, P398, DOI 10.1016/j.dld.2004.01.022
   Loguercio C, 2002, AM J GASTROENTEROL, V97, P2144
   Loguercio C, 2001, J HEPATOL, V35, P568, DOI 10.1016/S0168-8278(01)00192-1
   LOMBES A, 1989, ANN NEUROL, V26, P20, DOI 10.1002/ana.410260104
   LUDWIG J, 1980, MAYO CLIN PROC, V55, P434
   Luque CA, 1999, ANN PHARMACOTHER, V33, P968, DOI 10.1345/aph.18319
   Maeda N, 2004, P NATL ACAD SCI USA, V101, P17801, DOI 10.1073/pnas.0406230101
   Marchesini G, 2003, HEPATOLOGY, V37, P917, DOI 10.1053/jhep.2003.50161
   Marchesini G, 2001, LANCET, V358, P893, DOI 10.1016/S0140-6736(01)06042-1
   Marrades MP, 2006, BIOCHEM BIOPH RES CO, V339, P785, DOI 10.1016/j.bbrc.2005.11.080
   MATSUMURA K, 2008, MOL CELL BIOL
   Matteoni CA, 1999, GASTROENTEROLOGY, V116, P1413, DOI 10.1016/S0016-5085(99)70506-8
   McLaren D S, 1972, Prog Liver Dis, V4, P527
   Mendez-Sanchez Nahum, 2004, Ann Hepatol, V3, P108
   Merat S, 2003, J HEPATOL, V38, P414, DOI 10.1016/S0168-8278(02)00441-5
   Merat S, 2003, J CLIN GASTROENTEROL, V36, P266, DOI 10.1097/00004836-200303000-00015
   Miglio F, 2000, ARZNEIMITTEL-FORSCH, V50, P722
   Modica S, 2006, FEBS LETT, V580, P5492, DOI 10.1016/j.febslet.2006.07.082
   Mohanty P, 2004, J CLIN ENDOCR METAB, V89, P2728, DOI 10.1210/jc.2003-032103
   Morishita Y, 2004, J PHARMACOL SCI, V96, P276, DOI 10.1254/jphs.FMJ04004X7
   Murase T, 2005, BBA-MOL CELL BIOL L, V1733, P224, DOI 10.1016/j.bbalip.2004.12.015
   Nagasawa T, 2006, EUR J PHARMACOL, V536, P182, DOI 10.1016/j.ejphar.2006.02.028
   Nair S, 2001, AM J GASTROENTEROL, V96, P1200, DOI 10.1111/j.1572-0241.2001.03702.x
   NEUNER P, 1994, IMMUNOLOGY, V83, P262
   Neuschwander-Tetri BA, 2003, HEPATOLOGY, V38, P1008, DOI 10.1053/jhep.2003.50420
   NeuschwanderTetri BA, 1996, MED CLIN N AM, V80, P1147, DOI 10.1016/S0025-7125(05)70483-1
   Nissen SE, 2007, NEW ENGL J MED, V356, P2457, DOI 10.1056/NEJMoa072761
   Okan A, 2002, DIGEST DIS SCI, V47, P2389, DOI 10.1023/A:1020523017873
   Okita M, 2001, NUTRITION, V17, P542, DOI 10.1016/S0899-9007(01)00543-3
   Orlando R, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005160.pub2
   OSMAN E, 1993, ALIMENT PHARM THER, V7, P21
   Österreicher CH, 2007, ANN HEPATOL, V6, P83
   Österreicher CH, 2007, SEMIN LIVER DIS, V27, P28, DOI 10.1055/s-2006-960169
   Palmieri VO, 2006, J NUTR, V136, P3022, DOI 10.1093/jn/136.12.3022
   Pamuk GE, 2003, J GASTROEN HEPATOL, V18, P1220
   Parekh S, 2007, GASTROENTEROLOGY, V132, P2191, DOI 10.1053/j.gastro.2007.03.055
   PARKES J, 2006, C J HEPATOLOGY, V44, P462
   Patsouris D, 2004, J CLIN INVEST, V114, P94, DOI 10.1172/JC1200420468
   Pawlosky RJ, 2004, ALCOHOL CLIN EXP RES, V28, P1569, DOI 10.1097/01.ALC.0000141810.22855.4E
   PEREZVARRERAS M, 2003, HEPATOLOGY, V39, P999
   Pessayre D, 2001, SEMIN LIVER DIS, V21, P57, DOI 10.1055/s-2001-12929
   Petricoin E, 2004, J PROTEOME RES, V3, P209, DOI 10.1021/pr049972m
   PLOEG RJ, 1993, TRANSPLANTATION, V55, P807, DOI 10.1097/00007890-199304000-00024
   Portincasa P, 2006, BEST PRACT RES CL GA, V20, P1017, DOI 10.1016/j.bpg.2006.05.005
   Portincasa P, 2005, CLIN BIOCHEM, V38, P203, DOI 10.1016/j.clinbiochem.2004.10.014
   Portincasa P, 2003, J HEPATOL, V39, P864, DOI 10.1016/S0168-8278(03)00294-0
   Portincasa P, 2003, DIGEST LIVER DIS, V35, P118, DOI 10.1016/S1590-8658(03)00009-4
   Portincasa P, 2006, CURR MED CHEM, V13, P2889, DOI 10.2174/092986706778521878
   Portincasa P, 2006, CLIN SCI, V111, P135, DOI 10.1042/CS20050346
   Portincasa P, 2006, LANCET, V368, P230, DOI 10.1016/S0140-6736(06)69044-2
   Portincasa P, 2005, WORLD J GASTROENTERO, V11, P7, DOI 10.3748/wjg.v11.i1.7
   Promrat K, 2004, HEPATOLOGY, V39, P188, DOI 10.1002/hep.20012
   Prudente S, 2007, DIABETES, V56, P1468, DOI 10.2337/db06-1389
   Rallidis LS, 2004, ATHEROSCLEROSIS, V174, P127, DOI 10.1016/j.atherosclerosis.2004.01.013
   Ramalho LNZ, 2002, HEPATO-GASTROENTEROL, V49, P1499
   Rao MS, 2002, IN VIVO, V16, P145
   Ratziu V, 2000, GASTROENTEROLOGY, V118, P1117, DOI 10.1016/S0016-5085(00)70364-7
   Razani B, 2002, J BIOL CHEM, V277, P8635, DOI 10.1074/jbc.M110970200
   Reddy JK, 2001, AM J PHYSIOL-GASTR L, V281, pG1333, DOI 10.1152/ajpgi.2001.281.6.G1333
   REID AE, 2006, GASTROINTERTINAL DIS, P1793
   RINALDICARMONA M, 1994, FEBS LETT, V350, P240, DOI 10.1016/0014-5793(94)00773-X
   Robertson Graham, 2001, American Journal of Physiology, V281, pG1135
   Rojek AM, 2007, P NATL ACAD SCI USA, V104, P3609, DOI 10.1073/pnas.0610894104
   Rosenberg WMC, 2004, GASTROENTEROLOGY, V127, P1704, DOI 10.1053/j.gastro.2004.08.052
   Rubbia-Brandt L, 2001, HISTOPATHOLOGY, V39, P119, DOI 10.1046/j.1365-2559.2001.01208.x
   Sabuncu Tevfik, 2003, Rom J Gastroenterol, V12, P189
   Saibara T, 1999, LANCET, V353, P1802, DOI 10.1016/S0140-6736(05)75907-9
   Sam S, 2003, TRENDS ENDOCRIN MET, V14, P365, DOI 10.1016/j.tem.2003.08.002
   Sandrin L, 2003, ULTRASOUND MED BIOL, V29, P1705, DOI 10.1016/j.ultrasmedbio.2003.07.001
   Santos VN, 2003, BRAZ J MED BIOL RES, V36, P723, DOI 10.1590/S0100-879X2003000600007
   Sanyal AJ, 2001, GASTROENTEROLOGY, V120, P1183, DOI 10.1053/gast.2001.23256
   Sanyal AJ, 2004, CLIN GASTROENTEROL H, V2, P1107, DOI 10.1016/S1542-3565(04)00457-4
   Sebastiani G, 2006, J HEPATOL, V44, P686, DOI 10.1016/j.jhep.2006.01.007
   Shoelson SE, 2007, GASTROENTEROLOGY, V132, P2169, DOI 10.1053/j.gastro.2007.03.059
   Shulman AI, 2005, NEW ENGL J MED, V353, P604, DOI 10.1056/NEJMra043590
   SILVERMAN JF, 1990, AM J GASTROENTEROL, V85, P1349
   SOKOL RJ, 1994, GASTROENTEROLOGY, V107, P1788, DOI 10.1016/0016-5085(94)90822-2
   Solga S, 2004, DIGEST DIS SCI, V49, P1578, DOI 10.1023/B:DDAS.0000043367.69470.b7
   Solga SF, 2003, J HEPATOL, V38, P681, DOI 10.1016/S0168-8278(03)00097-7
   Soza A, 2005, DIGEST DIS SCI, V50, P1136, DOI 10.1007/s10620-005-2720-8
   Spycher C, 2001, BMC Gastroenterol, V1, P12, DOI 10.1186/1471-230X-1-12
   Stern L, 2004, ANN INTERN MED, V140, P778, DOI 10.7326/0003-4819-140-10-200405180-00007
   Stewart SF, 2004, HEPATOLOGY, V39, P197, DOI 10.1002/hep.20021
   Struben VMD, 2000, AM J MED, V108, P9, DOI 10.1016/S0002-9343(99)00315-0
   Tambascia MA, 2003, DIABETES OBES METAB, V5, P338, DOI 10.1046/j.1463-1326.2003.00285.x
   Tenenbaum A, 2005, CARDIOVASC DIABETOL, V4, DOI 10.1186/1475-2840-4-14
   Tilg H, 2000, NEW ENGL J MED, V343, P1467, DOI 10.1056/NEJM200011163432007
   Torgerson JS, 2004, DIABETES CARE, V27, P155, DOI 10.2337/diacare.27.1.155
   Trayhurn P, 2005, ENDOCRINOLOGY, V146, P1003, DOI 10.1210/en.2004-1597
   Trayhurn P, 2005, BIOCHEM SOC T, V33, P1078, DOI [10.1042/BST0331078, 10.1042/BST20051078]
   Uygun A, 2004, ALIMENT PHARM THER, V19, P537, DOI 10.1111/j.1365-2036.2004.01888.x
   Valsamakis G, 2004, METABOLISM, V53, P430, DOI 10.1016/j.metabol.2003.11.022
   Van Gaal LF, 2005, LANCET, V365, P1389, DOI 10.1016/S0140-6736(05)66374-X
   Verkman AS, 2005, J CELL SCI, V118, P3225, DOI 10.1242/jcs.02519
   Viganò M, 2000, GASTROENTEROLOGY, V118, P986, DOI 10.1016/S0016-5085(00)70193-4
   Vitale C, 2005, CARDIOVASC DIABETOL, V4, DOI 10.1186/1475-2840-4-6
   Wai CT, 2003, HEPATOLOGY, V38, P518, DOI 10.1053/jhep.2003.50346
   Wajchenberg BL, 2000, ENDOCR REV, V21, P697, DOI 10.1210/er.21.6.697
   Wang F, 2006, ACTA PHARMACOL SIN, V27, P395, DOI 10.1111/j.1745-7254.2006.00318.x
   Weiner R, 1999, OBES SURG, V9, P261, DOI 10.1381/096089299765553133
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Weltman MD, 1998, HEPATOLOGY, V27, P128, DOI 10.1002/hep.510270121
   Wigg AJ, 2001, GUT, V48, P206, DOI 10.1136/gut.48.2.206
   Willner IR, 2001, AM J GASTROENTEROL, V96, P2957
   Yakaryilmaz F, 2007, INTERN MED J, V37, P229, DOI 10.1111/j.1445-5994.2006.01295.x
   Yang SQ, 1997, P NATL ACAD SCI USA, V94, P2557, DOI 10.1073/pnas.94.6.2557
   Yesilova Z, 2005, AM J GASTROENTEROL, V100, P850, DOI 10.1111/j.1572-0241.2005.41500.x
   Yki-Jarvinen H, 2004, NEW ENGL J MED, V351, P1106, DOI 10.1056/NEJMra041001
   Yokohama S, 2004, HEPATOLOGY, V40, P1222, DOI 10.1002/hep.20420
   Yoshiji H, 2002, J HEPATOL, V37, P22, DOI 10.1016/S0168-8278(02)00104-6
   Yoshiji H, 2001, HEPATOLOGY, V34, P745, DOI 10.1053/jhep.2001.28231
   Younossi ZM, 2004, CLIN GASTROENTEROL H, V2, P262, DOI 10.1016/S1542-3565(04)00014-X
NR 235
TC 40
Z9 45
U1 1
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1472-8222
EI 1744-7631
J9 EXPERT OPIN THER TAR
JI Expert Opin. Ther. Targets
PD SEP
PY 2007
VL 11
IS 9
BP 1231
EP 1249
DI 10.1517/14728222.11.9.1231
PG 19
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 216DC
UT WOS:000249857100009
PM 17845148
DA 2025-06-11
ER

PT J
AU Liu, WL
   Xu, YY
   Xiao, LL
   Li, K
   Liu, Q
AF Liu, Weili
   Xu, Yingying
   Xiao, Liling
   Li, Ke
   Liu, Qiang
TI Composite dietary antioxidant index is associated with the prevalence of
   metabolic syndrome in females: results from NHANES 2011-2016
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE NHANES; metabolic syndrome; CDAI; estrogen; females
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; RISK; CANCER; 17-BETA-ESTRADIOL;
   EXPRESSION; MENOPAUSE; ESTROGENS
AB Objective: This study sought to investigate the association between metabolic syndrome (MetS) and Composite Dietary Antioxidant Index (CDAI) in females, with the goal of informing evidence-based prevention and clinical management strategies for MetS. Methods: The 2011-2016 National Health and Nutrition Examination Survey (NHANES) recruited a total of 2,790 female participants and screened 1,562 participants for estrogen non-deficiency. The diagnosis of MetS was based on criteria set by the National Cholesterol Education Program-Adult Treatment Panel III. The CDAI was calculated according to the intake of 10 dietary antioxidants. Multivariable logistic regression was performed to investigate the relationship between the CDAI and MetS in females. We also performed restricted cubic splines, two-piecewise linear regression, and subgroup analysis in further analysis. Results: Our analyses demonstrated a significant inverse association between the Composite Dietary Antioxidant Index (CDAI) and metabolic syndrome (MetS) prevalence in females. Restricted cubic spline analysis indicated a linear dose-response relationship (p for linearity = 0.029), with two-piecewise linear regression analysis revealed an inflection point at 1.99. Below 1.99, each unit increase in the CDAI was associated with a 2% reduction in the risk of MetS in females; above 1.99, the risk reduction was 1%. Participants without MetS were significantly younger than those with MetS (43.49 +/- 16.04 vs. 54.77 +/- 15.52 years, p < 0.001). Notably, estrogen levels also were negatively correlated with the prevalence of MetS. Subgroup analysis revealed that the relationship between the CDAI and MetS remained consistent across all subgroups. Conclusion: In the female population, CDAI levels exhibited an inverse relationship with the prevalence of metabolic syndrome, and estrogen levels demonstrated a negative correlation with its incidence.
C1 [Liu, Weili; Xiao, Liling; Liu, Qiang] Shifang Peoples Hosp, Shifang, Peoples R China.
   [Xu, Yingying; Li, Ke] Univ Elect Sci & Technol China, Sch Life Sci & Technol, Chengdu, Peoples R China.
C3 University of Electronic Science & Technology of China
RP Liu, Q (corresponding author), Shifang Peoples Hosp, Shifang, Peoples R China.; Li, K (corresponding author), Univ Elect Sci & Technol China, Sch Life Sci & Technol, Chengdu, Peoples R China.
EM colinlike@163.com; sfsrmyykjk@163.com
FU Sichuan Provincial Science and Technology Achievement Transfer and
   Transformation Guidance Program [24ZHSF0072]; Sichuan Provincial Key
   Research and Development Program, Sichuan, China [25QYCX0359]
FX The author(s) declare that financial support was received for the
   research and/or publication of this article. This work was supported by
   2024 Sichuan Provincial Science and Technology Achievement Transfer and
   Transformation Guidance Program (No. 24ZHSF0072) and 2025 Sichuan
   Provincial Key Research and Development Program (No. 25QYCX0359),
   Sichuan, China.
CR Beydoun MA, 2019, NUTR REV, V77, P32, DOI 10.1093/nutrit/nuy044
   Borrás C, 2005, AGING CELL, V4, P113, DOI 10.1111/j.1474-9726.2005.00151.x
   Borrás C, 2003, FREE RADICAL BIO MED, V34, P546, DOI 10.1016/S0891-5849(02)01356-4
   Cano-Ibáñez N, 2019, NUTRIENTS, V11, DOI 10.3390/nu11050958
   Cespedes EM, 2015, AM J CLIN NUTR, V101, P899, DOI 10.3945/ajcn.115.110213
   Chew NWS, 2023, CELL METAB, V35, P414, DOI 10.1016/j.cmet.2023.02.003
   Colak E, 2021, J MED BIOCHEM, V40, P1, DOI 10.5937/jomb0-24652
   Daneshzad E, 2020, CLIN NUTR ESPEN, V37, P187, DOI 10.1016/j.clnesp.2020.03.002
   De Paoli M, 2021, AM J PATHOL, V191, P1490, DOI 10.1016/j.ajpath.2021.05.011
   de Rooij SR, 2009, DIABETES CARE, V32, P1295, DOI 10.2337/dc08-1795
   Delavari A, 2009, DIABETES CARE, V32, P1092, DOI 10.2337/dc08-1800
   Demmig-Adams B, 2002, SCIENCE, V298, P2149, DOI 10.1126/science.1078002
   Díaz A, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/6734836
   Dieli-Conwright CM, 2018, J CLIN ONCOL, V36, P875, DOI 10.1200/JCO.2017.75.7526
   Esposito K, 2012, DIABETES CARE, V35, P2402, DOI 10.2337/dc12-0336
   Forrester SJ, 2018, CIRC RES, V122, P877, DOI 10.1161/CIRCRESAHA.117.311401
   Franco C, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms232214489
   Geng QH, 2019, INT J BIOL SCI, V15, P58, DOI 10.7150/ijbs.25783
   Guo HB, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.728880
   Gupta A, 2010, BIOSCI TRENDS, V4, P204
   Hildrum B, 2007, BMC PUBLIC HEALTH, V7, DOI 10.1186/1471-2458-7-220
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Hutcheson R, 2012, EXP DIABETES RES, DOI 10.1155/2012/271028
   Janssen I, 2008, ARCH INTERN MED, V168, P1568, DOI 10.1001/archinte.168.14.1568
   Jeong J, 2019, J KOREAN MED SCI, V34, DOI 10.3346/jkms.2019.34.e307
   Katzer K, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222111720
   Klinge CM, 2017, J BIOENERG BIOMEMBR, V49, P307, DOI 10.1007/s10863-017-9704-1
   Ko SH, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010202
   Liakopoulos V, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/9109473
   Liao SJ, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11091785
   Liao ZY, 2024, EUR REV MED PHARMACO, V28, P1513, DOI 10.26355/eurrev_202402_35481
   Liu Y, 2025, CELL METAB, V37, DOI 10.1016/j.cmet.2025.01.014
   Manolagas SC, 2010, ENDOCR REV, V31, P266, DOI 10.1210/er.2009-0024
   Masenga SK, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24097898
   Mauvais-Jarvis F, 2013, ENDOCR REV, V34, P309, DOI 10.1210/er.2012-1055
   Mendonça FM, 2015, METABOLISM, V64, P182, DOI 10.1016/j.metabol.2014.10.008
   Min SH, 2022, WOMENS HEALTH, V18, DOI 10.1177/17455057221083817
   Monteiro R, 2014, MEDIAT INFLAMM, V2014, DOI 10.1155/2014/615917
   Padgett LE, 2013, ANN NY ACAD SCI, V1281, P16, DOI 10.1111/j.1749-6632.2012.06826.x
   Palmiero Pasquale, 2021, Acta Biomed, V92, pe2021177, DOI 10.23750/abm.v92i3.11335
   Panchal SK, 2017, CURR HYPERTENS REP, V19, DOI 10.1007/s11906-017-0701-x
   Pu D, 2017, CLIMACTERIC, V20, P583, DOI 10.1080/13697137.2017.1386649
   Quail DF, 2019, NAT REV ENDOCRINOL, V15, P139, DOI 10.1038/s41574-018-0126-x
   Reis J, 2023, NAT CHEM BIOL, V19, P1540, DOI 10.1038/s41589-023-01457-5
   Retondario A, 2019, CLIN NUTR, V38, P603, DOI 10.1016/j.clnu.2018.02.021
   Roumeliotis S, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081911
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Santa K, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24032627
   Sanz Raul Lelio, 2024, World J Exp Med, V14, P91519, DOI 10.5493/wjem.v14.i2.91519
   Schleicher RL, 2009, AM J CLIN NUTR, V90, P1252, DOI 10.3945/ajcn.2008.27016
   Takahashi TA, 2015, MED CLIN N AM, V99, P521, DOI 10.1016/j.mcna.2015.01.006
   Thomas MS, 2022, NUTRIENTS, V14, DOI 10.3390/nu14122548
   Ulas M, 2010, ACTA PHYSIOL HUNG, V97, P208, DOI 10.1556/APhysiol.97.2010.2.7
   Vona R, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8267234
   Wilkinson MJ, 2020, CELL METAB, V31, P92, DOI 10.1016/j.cmet.2019.11.004
   Wright ME, 2004, AM J EPIDEMIOL, V160, P68, DOI 10.1093/aje/kwh173
   Wu MY, 2023, CLIN EXP HYPERTENS, V45, DOI 10.1080/10641963.2023.2233712
   Yu YC, 2022, INT J CANCER, V150, P1599, DOI 10.1002/ijc.33925
   Zhang T, 2022, GUT, V71, P78, DOI 10.1136/gutjnl-2020-323347
   Zhang YQ, 2025, CELL DISCOV, V11, DOI 10.1038/s41421-025-00769-1
   Zhao LY, 2022, FRONT PUBLIC HEALTH, V10, DOI 10.3389/fpubh.2022.988727
   Zhou Q, 2024, PREV MED REP, V41, DOI 10.1016/j.pmedr.2024.102704
NR 62
TC 0
Z9 0
U1 3
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD MAR 27
PY 2025
VL 12
AR 1529332
DI 10.3389/fnut.2025.1529332
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1HX1Y
UT WOS:001465419800001
PM 40212720
OA gold
DA 2025-06-11
ER

PT J
AU Idres, YA
   Tousch, D
   Cazals, G
   Lebrun, A
   Naceri, S
   Bidel, LPR
   Poucheret, P
AF Idres, Yanis A.
   Tousch, Didier
   Cazals, Guillaume
   Lebrun, Aurelien
   Naceri, Sarah
   Bidel, Luc P. R.
   Poucheret, Patrick
TI A Novel Sesquiterpene Lactone Xanthatin-13-(pyrrolidine-2-carboxylic
   acid) Isolated from Burdock Leaf Up-Regulates Cells' Oxidative Stress
   Defense Pathway
SO ANTIOXIDANTS
LA English
DT Article
DE burdock leaf; sesquiterpene lactones; xanthonolide; oxidative stress;
   glucose-6-phosphodeshydrogenase; molecular docking
ID XANTHIUM-STRUMARIUM L.; CICHORIUM-INTYBUS L.; NF-KAPPA-B; CHICORIC ACID;
   DUAL ROLES; IN-VITRO; GLUCOSE-6-PHOSPHATE-DEHYDROGENASE; XANTHATIN;
   EXTRACT; EXPRESSION
AB The aim of our study was to identify novel molecules able to induce an adaptative response against oxidative stress during the first stages of metabolic syndrome. A cellular survival in vitro test against H2O2-based test was applied after pretreatment with various natural bitter Asteraceae extracts. This screening revealed potent protection from burdock leaf extract. Using chromatography and LC-MS-RMN, we then isolated and identified an original sesquiterpene lactone bioactive molecule: the Xanthatin-13-(pyrrolidine-2-carboxylic acid) (XPc). A real-time RT-qPCR experiment was carried out on three essential genes involved in oxidative stress protection: GPx, SOD, and G6PD. In presence of XPc, an over-expression of the G6PD gene was recorded, whereas no modification of the two others genes could be observed. A biochemical docking approach demonstrated that XPc had a high probability to directly interact with G6PD at different positions. One of the most probable docking sites corresponds precisely to the binding site of AG1, known to stabilize the G6PD dimeric form and enhance its activity. In conclusion, this novel sesquiterpene lactone XPc might be a promising prophylactic bioactive agent against oxidative stress and inflammation in chronic diseases such as metabolic syndrome or type 2 diabetes.</p>
C1 [Idres, Yanis A.; Tousch, Didier; Poucheret, Patrick] Univ Montpellier, SupAgro Montpellier, CIRAD, UMR Qualisud 95, 15 Ave Charles Flahault,BP 14491, F-34093 Montpellier 5, France.
   [Cazals, Guillaume; Lebrun, Aurelien] Univ Montpellier, Lab Mesure Phys, Pl Eugene Bataillon, F-34093 Montpellier 5, France.
   [Naceri, Sarah] Univ Paris, Lab Biol Fonct & Adaptat, CNRS, UMR 8251, 35 Rue Helene Br, F-75013 Paris, France.
   [Bidel, Luc P. R.] SupAgro, CIRAD, INRA, UMR AGAP, 2 Pl Pierre Viala, F-34060 Montpellier, France.
C3 CIRAD; Institut Agro; Montpellier SupAgro; Universite de Montpellier;
   Universite de Montpellier; Centre National de la Recherche Scientifique
   (CNRS); CNRS - National Institute for Biology (INSB); Universite Paris
   Cite; Universite de Montpellier; INRAE; Institut Agro; Montpellier
   SupAgro; CIRAD
RP Idres, YA; Tousch, D (corresponding author), Univ Montpellier, SupAgro Montpellier, CIRAD, UMR Qualisud 95, 15 Ave Charles Flahault,BP 14491, F-34093 Montpellier 5, France.
EM guillaume.cazals@umontpellier.fr; sarah.naceri@etu.u-paris.fr;
   luc.bidel@inrae.fr; patrick.poucheret@umontpellier.fr
RI Aurelien, LEBRUN/HXK-2092-2023; Didier, Tousch/HKM-7752-2023
OI Lebrun, Aurelien/0000-0002-0801-9684
CR Alonso M.R., 2018, Sesquiterpene Lact, P325, DOI [10.1007/978-3-319-78274-4_14, DOI 10.1007/978-3-319-78274-414]
   Awwad A., 2020, NFS J, V18, P29, DOI [10.1016/j.nfs.2020.01.001, DOI 10.1016/J.NFS.2020.01.001]
   Awwad A, 2021, MOLECULES, V26, DOI 10.3390/molecules26185566
   Azay-Milhau J, 2013, J ETHNOPHARMACOL, V150, P755, DOI 10.1016/j.jep.2013.09.046
   Berman HM, 2000, NUCLEIC ACIDS RES, V28, P235, DOI 10.1093/nar/28.1.235
   Bermúdez-Muñoz JM, 2020, AGING CELL, V19, DOI 10.1111/acel.13275
   Bonomini F, 2015, AGING DIS, V6, P109, DOI 10.14336/AD.2014.0305
   BONSIGNORE A, 1971, BIOCHEM BIOPH RES CO, V43, P94, DOI 10.1016/S0006-291X(71)80091-8
   Bork PM, 1997, FEBS LETT, V402, P85, DOI 10.1016/S0014-5793(96)01502-5
   Burton GJ, 2011, BEST PRACT RES CL OB, V25, P287, DOI 10.1016/j.bpobgyn.2010.10.016
   Chen SJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0045693
   Cosconati S, 2010, EXPERT OPIN DRUG DIS, V5, P597, DOI 10.1517/17460441.2010.484460
   Dong J, 2008, ANTIOXID REDOX SIGN, V10, P2023, DOI 10.1089/ars.2007.2019
   El Khatib N, 2021, MOLECULES, V26, DOI 10.3390/molecules26051328
   Soto ME, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/760694
   Ferrare K, 2018, J ETHNOPHARMACOL, V215, P241, DOI 10.1016/j.jep.2017.12.035
   Finkel T, 2000, NATURE, V408, P239, DOI 10.1038/35041687
   Formisano C, 2017, FITOTERAPIA, V116, P61, DOI 10.1016/j.fitote.2016.11.006
   Frederiks WM, 2003, J HISTOCHEM CYTOCHEM, V51, P105, DOI 10.1177/002215540305100112
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Garcia AA, 2021, TRENDS PHARMACOL SCI, V42, P829, DOI 10.1016/j.tips.2021.07.002
   García-Sánchez A, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/2082145
   He F, 2020, CARCINOGENESIS, V41, P405, DOI 10.1093/carcin/bgaa039
   HUANG CS, 1993, J BIOL CHEM, V268, P19675
   Hussain T, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/7432797
   Hwang S, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-06447-z
   Kim IT, 2005, BIOL PHARM BULL, V28, P94, DOI 10.1248/bpb.28.94
   Koes DR, 2013, J CHEM INF MODEL, V53, P1893, DOI 10.1021/ci300604z
   Krzywanski DM, 2004, ARCH BIOCHEM BIOPHYS, V423, P116, DOI 10.1016/j.abb.2003.11.004
   Kurata M, 2000, COMP HAEMATOL INT, V10, P59, DOI 10.1007/s005800070009
   Lau A, 2008, PHARMACOL RES, V58, P262, DOI 10.1016/j.phrs.2008.09.003
   Liu RJ, 2018, MOL PHARMACEUT, V15, P3285, DOI 10.1021/acs.molpharmaceut.8b00338
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   Lu SC, 2013, BBA-GEN SUBJECTS, V1830, P3143, DOI 10.1016/j.bbagen.2012.09.008
   Lu SC, 2009, MOL ASPECTS MED, V30, P42, DOI 10.1016/j.mam.2008.05.005
   Menegon S, 2016, TRENDS MOL MED, V22, P578, DOI 10.1016/j.molmed.2016.05.002
   Merfort I, 2011, CURR DRUG TARGETS, V12, P1560, DOI 10.2174/138945011798109437
   Mittler R, 2017, TRENDS PLANT SCI, V22, P11, DOI 10.1016/j.tplants.2016.08.002
   Nóbrega-Pereira S, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms10894
   O'Boyle NM, 2011, J CHEMINFORMATICS, V3, DOI 10.1186/1758-2946-3-33
   Pacher P, 2007, PHYSIOL REV, V87, P315, DOI 10.1152/physrev.00029.2006
   PANDOLFI PP, 1995, EMBO J, V14, P5209, DOI 10.1002/j.1460-2075.1995.tb00205.x
   Ramírez-Erosa I, 2007, CAN J PHYSIOL PHARM, V85, P1160, DOI 10.1139/Y07-104
   Raub AG, 2019, CHEMMEDCHEM, V14, P1321, DOI 10.1002/cmdc.201900341
   Ray PD, 2012, CELL SIGNAL, V24, P981, DOI 10.1016/j.cellsig.2012.01.008
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Rüngeler P, 1999, BIOORGAN MED CHEM, V7, P2343, DOI 10.1016/S0968-0896(99)00195-9
   Saddala MS, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21041523
   Sadeghi MR, 2017, TUMOR BIOL, V39, DOI 10.1177/1010428317705510
   Salvemini F, 1999, J BIOL CHEM, V274, P2750, DOI 10.1074/jbc.274.5.2750
   Sies H, 2017, ANNU REV BIOCHEM, V86, P715, DOI 10.1146/annurev-biochem-061516-045037
   Song EK, 2019, NUTR RES, V70, P60, DOI 10.1016/j.nutres.2018.09.011
   Umemura K, 2008, BIOCHEM BIOPH RES CO, V368, P948, DOI 10.1016/j.bbrc.2008.02.018
   Ursini MV, 1997, BIOCHEM J, V323, P801, DOI 10.1042/bj3230801
   Vargas-Mendoza N, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8060196
   Wu B, 2009, ENDOCR J, V56, P773, DOI 10.1507/endocrj.K08E-332
   Yang HC, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8091055
   Yang Y, 2007, BIOCHEM PHARMACOL, V74, P372, DOI 10.1016/j.bcp.2007.02.003
   Zhang L, 2012, MOLECULES, V17, P3736, DOI 10.3390/molecules17043736
   Zhang Siyuan, 2005, Current Medicinal Chemistry - Anti-Cancer Agents, V5, P239, DOI 10.2174/1568011053765976
   Zhi XY, 2020, BIOORG CHEM, V97, DOI 10.1016/j.bioorg.2020.103696
NR 61
TC 4
Z9 4
U1 1
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD OCT
PY 2021
VL 10
IS 10
AR 1617
DI 10.3390/antiox10101617
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA WQ6EF
UT WOS:000713906700001
PM 34679753
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhong, XM
   Ming, JX
   Li, CQ
AF Zhong, Xuemin
   Ming, Jinxuan
   Li, Changqing
TI Association between dyslipidemia and depression: a cross-sectional
   analysis of NHANES data from 2007 to 2018
SO BMC PSYCHIATRY
LA English
DT Article
DE Dyslipidemia; Depression; High-density Lipoprotein Cholesterol;
   Low-Density Lipoprotein Cholesterol; Triglycerides; Triglyceride glucose
   index
ID METABOLIC SYNDROME; SERUM-CHOLESTEROL; MAJOR DEPRESSION; BIPOLAR
   DISORDER; LIPID-LEVELS; SYMPTOMS; INCONTINENCE; METAANALYSIS; CORONARY;
   HISTORY
AB Background The relationship between depression and dyslipidemia remains controversial, with inconsistent findings across studies. This study aimed to investigate the association between blood lipid levels and depression using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2007 to 2018. Methods This cross-sectional study included 12,819 adult participants from NHANES. Depression was assessed using a nine-item depression screening instrument. Serum lipid levels, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), were measured using Roche modular P and Roche Cobas 6000 chemistry analyzers. Survey-weighted multiple logistic regression was used to assess the relationships between serum lipid levels and depression. Results We observed a statistically significant negative association between HDL levels and depression (odds ratio [OR]: 0.72, 95% confidence interval [CI]: 0.58-0.90). After adjustments for covariates, HDL-C, TG, and the triglyceride glucose (TyG) index showed significant associations with depression (ORs: 0.66, 1.08, and 1.01, respectively). A linear correlation was observed between HDL-C levels and depression (P < 0.01), while TG levels and the TyG index exhibited nonlinear associations (p < 0.01 and p < 0.05, respectively). No significant positive associations were observed between increased TC or LDL-C levels and the risk of depression. Conclusions High HDL-C levels were negatively associated with depression, while TG levels and the TyG index were positively associated with depression. Clinical attention should be given to the detection of lipid levels in patients with depression.
C1 [Zhong, Xuemin; Li, Changqing] Chongqing Med Univ, Affiliated Hosp 2, Chongqing, Peoples R China.
   [Zhong, Xuemin] Second Peoples Hosp Chengdu, Chengdu, Peoples R China.
   [Ming, Jinxuan] Southwest Med Univ, Luzhou, Peoples R China.
C3 Chongqing Medical University; Southwest Medical University
RP Li, CQ (corresponding author), Chongqing Med Univ, Affiliated Hosp 2, Chongqing, Peoples R China.
EM licq@cqmu.edu.cn
RI zhong, xuemin/JFS-8578-2023
CR Agatisa PIK, 2005, ARCH INTERN MED, V165, P1229, DOI 10.1001/archinte.165.11.1229
   Akinbami LJ., 2022, Vital Health Stat, V1 190, P1, DOI DOI 10.15620/CDC:115434
   Ancelin ML, 2010, BIOL PSYCHIAT, V68, P125, DOI 10.1016/j.biopsych.2010.04.011
   Association AP, 2013, Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
   Bayturan O, 2010, ARCH INTERN MED, V170, P478, DOI 10.1001/archinternmed.2009.551
   Beydoun MA, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.4
   Centers for Disease Control and Prevention (CDC) National Center for Health Statistics (NCHS), 2003, National Health and Nutrition Examination Survey Data
   Chen CC, 2001, PSYCHIAT RES, V102, P153, DOI 10.1016/S0165-1781(01)00231-1
   Chunxiao D, 2008, Study on blood lipid levels in comorbidities of depression, anxiety disorder and anxiety-depression disorder D
   Dortland AKBV, 2010, J CLIN PSYCHIAT, V71, P729, DOI 10.4088/JCP.08m04865blu
   Elovainio M, 2010, HEALTH PSYCHOL, V29, P237, DOI 10.1037/a0018875
   ENGELBERG H, 1992, LANCET, V339, P727, DOI 10.1016/0140-6736(92)90609-7
   Enko D, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0796-3
   Estrela M, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17228612
   GLUECK CJ, 1994, AM J MED SCI, V308, P218
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Ledochowski M, 2003, CLIN CHEM LAB MED, V41, P821, DOI 10.1515/CCLM.2003.124
   Lee JH, 2017, J AFFECT DISORDERS, V208, P553, DOI 10.1016/j.jad.2016.10.027
   Lehto SM, 2008, PROG NEURO-PSYCHOPH, V32, P1557, DOI 10.1016/j.pnpbp.2008.05.021
   Liu Y, 2012, J AFFECT DISORDERS, V139, P230, DOI 10.1016/j.jad.2011.08.003
   Silva NDLE, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00057
   Malhi GS, 2018, LANCET, V392, P2299, DOI 10.1016/S0140-6736(18)31948-2
   Mehdi S, 2023, BIOCHEM BIOPHYS REP, V36, DOI 10.1016/j.bbrep.2023.101571
   Meijer A, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-130
   Meshkat S, 2024, PSYCHIAT RES, V332, DOI 10.1016/j.psychres.2023.115709
   Moreira FP, 2017, J PSYCHIATR RES, V92, P119, DOI 10.1016/j.jpsychires.2017.03.025
   Nakao M, 2004, TOHOKU J EXP MED, V204, P273, DOI 10.1620/tjem.204.273
   Nieto MD, 2015, INT UROGYNECOL J, V26, P1483, DOI 10.1007/s00192-015-2730-9
   O'Loughlin J, 2023, BMC MED, V21, DOI 10.1186/s12916-023-02735-8
   Ong KL, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.232
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Parker Jennifer D, 2017, Vital Health Stat 2, P1
   Sampietro T, 2006, INT J CARDIOL, V108, P143, DOI 10.1016/j.ijcard.2005.04.036
   Shi YY, 2021, BMC PSYCHIATRY, V21, DOI 10.1186/s12888-021-03275-2
   Shin HY, 2016, INT J GERIATR PSYCH, V31, P1087, DOI 10.1002/gps.4429
   So HC, 2021, PSYCHOL MED, V51, P2357, DOI 10.1017/S0033291720000951
   Tedders SH, 2011, J AFFECT DISORDERS, V135, P115, DOI 10.1016/j.jad.2011.06.045
   Tomfohr LM, 2008, J BEHAV MED, V31, P137, DOI 10.1007/s10865-007-9141-4
   Nunes SOV, 2015, J AFFECT DISORDERS, V172, P55, DOI 10.1016/j.jad.2014.09.038
   Wang ZY, 2024, AM J PREVENT CARDIOL, V19, DOI 10.1016/j.ajpc.2024.100687
   Wu JM, 2015, J AM GERIATR SOC, V63, P947, DOI 10.1111/jgs.13385
   Xiangyu S., 2021, Int J Psychiatry, V004, P048
   Xiaodong S, 2022, Chin J Psychiatry, P469, DOI [10.3760/cma.J.cn113661-20220315-00059, DOI 10.3760/CMA.J.CN113661-20220315-00059]
   Yu B, 2015, J AFFECT DISORDERS, V172, P422, DOI 10.1016/j.jad.2014.10.026
   Zhang C, 2020, J PSYCHIATR RES, V130, P9, DOI 10.1016/j.jpsychires.2020.07.012
NR 46
TC 3
Z9 3
U1 2
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD DEC 6
PY 2024
VL 24
IS 1
AR 893
DI 10.1186/s12888-024-06359-x
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA O6K8E
UT WOS:001372199400001
PM 39643888
OA gold
DA 2025-06-11
ER

PT J
AU Sattari, M
   Amri, J
   Shahaboddin, ME
   Sattari, M
   Tabatabaei-Malazy, O
   Azmon, M
   Meshkani, R
   Panahi, G
AF Sattari, Mahboobe
   Amri, Jamal
   Shahaboddin, Mohammad Esmaeil
   Sattari, Mohadese
   Tabatabaei-Malazy, Ozra
   Azmon, Marzyeh
   Meshkani, Reza
   Panahi, Ghodratollah
TI The protective effects of fisetin in metabolic disorders: a focus on
   oxidative stress and associated events
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Review
ID LIPID-ACCUMULATION; INSULIN-RESISTANCE; HYDROGEN-PEROXIDE; EMERGING
   ROLE; NRF2; APOPTOSIS; INJURY; DAMAGE; CELLS; INFLAMMATION
AB Metabolic syndrome is increasingly recognized as a significant precursor to various chronic diseases, contributing to a growing public health concern. Its complex pathogenesis involves multiple interrelated mechanisms, with oxidative stress identified as a cornerstone that exacerbates other pathogenic pathways. This study elucidates the molecular mechanisms by which oxidative stress intensifies metabolic disturbances, particularly insulin resistance. Some recent research has focused on fisetin, a natural product known for its potential benefits in diabetes and its associated microvascular and macrovascular complications. This paper compiles a comprehensive collection of findings by reviewing studies conducted over the past decade, detailing dosages, investigated markers, and their respective outcomes. Notably, a recurrent finding was fisetin's ability to enhance Nrf2, a principal regulator of antioxidant defense, in both metabolic and non-metabolic diseases. Furthermore, intriguing results suggest that the effects of Nrf2 extend beyond oxidative stress modulation, demonstrating favorable impacts on tissue-specific functions in metabolic regulation. This highlights fisetin not only as an antioxidant but also as a potential therapeutic agent for improving metabolic health and mitigating the effects of metabolic syndrome. In conclusion, fisetin can enhance the body's antioxidant defenses by modulating the Nrf2 pathway while also improving metabolic health through its effects on inflammation, cell survival, and energy metabolism, offering a comprehensive approach to managing metabolic disorders.
C1 [Sattari, Mahboobe; Amri, Jamal; Meshkani, Reza; Panahi, Ghodratollah] Univ Tehran Med Sci, Fac Med, Dept Clin Biochem, Tehran, Iran.
   [Sattari, Mahboobe; Amri, Jamal] Univ Tehran Med Sci, Students Sci Res Ctr SSRC, Tehran, Iran.
   [Shahaboddin, Mohammad Esmaeil] Kashan Univ Med Sci, Inst Basic Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
   [Sattari, Mohadese] Kashan Univ Med Sci, Sch Med, Kashan, Iran.
   [Sattari, Mohadese] Kashan Univ Med Sci, Student Res Comm, Kashan, Iran.
   [Tabatabaei-Malazy, Ozra] Univ Tehran Med Sci, Endocrinol & Metab Populat Sci Inst, Noncommunicable Dis Res Ctr, Tehran, Iran.
   [Tabatabaei-Malazy, Ozra] Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Endocrinol & Metab Res Ctr, Tehran, Iran.
   [Azmon, Marzyeh] Mashhad Univ Med Sci, Fac Med, Dept Internal Med, Mashhad, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences; Tehran University of
   Medical Sciences; Mashhad University of Medical Sciences
RP Panahi, G (corresponding author), Univ Tehran Med Sci, Fac Med, Dept Clin Biochem, Tehran, Iran.
EM pshahriyar@gmail.com
RI panahi, shahriyar/W-3772-2019; Tabatabaei-Malazy, ozra/T-5561-2017;
   Shahaboddin, Mohamad/S-3334-2017
CR Afroze N, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23031707
   Ahmad A, 2019, J CLIN MED, V8, DOI 10.3390/jcm8060850
   Ahmad S, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.612078
   Akpa AR, 2021, TOXICOL RES-GER, V37, P163, DOI 10.1007/s43188-020-00049-y
   Alikatte K, 2021, J DIET SUPPL, V18, P57, DOI 10.1080/19390211.2019.1710646
   AlTamimi JZ, 2021, SAUDI PHARM J, V29, P27, DOI 10.1016/j.jsps.2020.12.003
   Althunibat OY, 2019, LIFE SCI, V221, P83, DOI 10.1016/j.lfs.2019.02.017
   Antika LD, 2021, ASIAN PAC J TROP BIO, V11, P1, DOI 10.4103/2221-1691.300726
   Arangia A, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24065076
   Behl T, 2021, MOL BIOL REP, V48, P927, DOI 10.1007/s11033-020-06081-3
   Bengal E, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21186480
   Bhakkiyalakshmi E, 2015, PHARMACOL RES, V91, P104, DOI 10.1016/j.phrs.2014.10.004
   Bhatti JS, 2022, FREE RADICAL BIO MED, V184, P114, DOI 10.1016/j.freeradbiomed.2022.03.019
   Chen JW, 2024, LIFE SCI, V338, DOI 10.1016/j.lfs.2023.122386
   Chen Z, 2020, FREE RADICAL BIO MED, V152, P116, DOI 10.1016/j.freeradbiomed.2020.02.025
   Choi MS, 2020, J MED FOOD, V23, P1019, DOI 10.1089/jmf.2019.4619
   Colak E, 2021, J MED BIOCHEM, V40, P1, DOI 10.5937/jomb0-24652
   Cordaro M, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10061448
   da Costa RM, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.00382
   Dai XL, 2022, J FUNCT FOODS, V90, DOI 10.1016/j.jff.2022.104954
   David JA, 2017, J DIABETES RES, V2017, DOI 10.1155/2017/4826724
   Di Meo Sergio, 2016, Oxid Med Cell Longev, V2016, P1245049, DOI 10.1155/2016/1245049
   Dodson M, 2022, DIABETES, V71, P2463, DOI 10.2337/db22-0623
   Dong B, 2018, J NUTR BIOCHEM, V62, P221, DOI 10.1016/j.jnutbio.2018.08.010
   Dong WM, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.783706
   El-Fadaly AA, 2022, IMMUNOPHARM IMMUNOT, V44, P355, DOI 10.1080/08923973.2022.2047198
   Gaballah HH, 2019, J CELL BIOCHEM, V120, P12762, DOI 10.1002/jcb.28544
   Garg S, 2020, ARCH BIOCHEM BIOPHYS, V694, DOI 10.1016/j.abb.2020.108572
   Garg S, 2019, PHYTOMEDICINE, V56, P147, DOI 10.1016/j.phymed.2018.09.187
   Ge CX, 2019, FREE RADICAL BIO MED, V141, P67, DOI 10.1016/j.freeradbiomed.2019.05.031
   Ge CX, 2019, FOOD FUNCT, V10, P2970, DOI 10.1039/c8fo01653d
   Grynkiewicz G, 2019, FRONT CHEM, V7, DOI 10.3389/fchem.2019.00697
   Gupta P, 2021, ADV PROTEIN CHEM STR, V124, P47, DOI 10.1016/bs.apcsb.2020.11.001
   Hassan RH, 2016, J BIOL CHEM, V291, P3019, DOI 10.1074/jbc.M115.686949
   Hu LF, 2020, J NUTR BIOCHEM, V77, DOI 10.1016/j.jnutbio.2019.108253
   Hussain T, 2019, J FOOD BIOCHEM, V43, DOI 10.1111/jfbc.12962
   Jackson MJ, 2020, REDOX BIOL, V35, DOI 10.1016/j.redox.2020.101484
   Jacob S, 2017, BIOL TRACE ELEM RES, V177, P297, DOI 10.1007/s12011-016-0886-x
   Jia QL, 2019, EUR J PHARMACOL, V865, DOI 10.1016/j.ejphar.2019.172748
   Ju HY, 2023, KIDNEY RES CLIN PRAC, V42, P325
   Juan CA, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22094642
   Kang KA, 2014, IN VITRO CELL DEV-AN, V50, P66, DOI 10.1007/s11626-013-9681-6
   Kattoor AJ, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8070218
   Khatoon S, 2023, EUR J PHARMACOL, V944, DOI 10.1016/j.ejphar.2023.175583
   Kim SG, 2023, ARCH GERONTOL GERIAT, V108, DOI 10.1016/j.archger.2023.104927
   Korbecki J, 2019, INFLAMM RES, V68, P443, DOI 10.1007/s00011-019-01231-1
   Kostanecki S., 1904, Ber Dtsch Chem Ges, V37, P784, DOI DOI 10.1002/CBER.190403701128
   Kumar A, 2017, INFLAMMOPHARMACOLOGY, V25, P393, DOI 10.1007/s10787-017-0339-y
   Kwak S, 2014, INFLAMM RES, V63, P779, DOI 10.1007/s00011-014-0750-4
   Lai MH, 2023, J OPHTHALMOL, V2023, DOI 10.1155/2023/7951928
   Lee SH, 2022, DIABETES METAB J, V46, P15, DOI 10.4093/dmj.2021.0280
   Li SR, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21186973
   Li T, 2023, NUTR METAB, V20, DOI 10.1186/s12986-023-00770-z
   Li ZX, 2021, ARCH MED RES, V52, P163, DOI 10.1016/j.arcmed.2020.10.009
   Lin YJ, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.1074911
   Liou CJ, 2018, CELL PHYSIOL BIOCHEM, V49, P1870, DOI 10.1159/000493650
   Lou YM, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/7866720
   Mahoney SA, 2024, AGING CELL, V23, DOI 10.1111/acel.14060
   Martemucci G, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12122091
   Masenga SK, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24097898
   Maurya BK, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/1972793
   Mihanfar A, 2021, J STEROID BIOCHEM, V213, DOI 10.1016/j.jsbmb.2021.105954
   Mohamed S.M., 2023, Food Chem Adv, V3, DOI 10.1016/j.focha.2023.100335
   Molagoda IMN, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10091492
   Monserrat-Mesquida M, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9030236
   More VR, 2013, FREE RADICAL BIO MED, V61, P85, DOI 10.1016/j.freeradbiomed.2013.03.007
   Nainu F, 2023, HELIYON, V9, DOI 10.1016/j.heliyon.2023.e16919
   Onyango AN, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/4321714
   Park C, 2023, J MICROBIOL BIOTECHN, V33, P591, DOI 10.4014/jmb.2212.12042
   Park C, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.927898
   Pei F, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/6625517
   Petersen MC, 2017, TRENDS PHARMACOL SCI, V38, P649, DOI 10.1016/j.tips.2017.04.004
   Pirani M, 2021, REPROD SCI, V28, P3123, DOI 10.1007/s43032-021-00615-1
   Prasath GS, 2014, J BIOCHEM MOL TOXIC, V28, P442, DOI 10.1002/jbt.21583
   Prasath GS, 2014, EUR J PHARMACOL, V740, P248, DOI 10.1016/j.ejphar.2014.06.065
   Prem PN, 2022, N-S ARCH PHARMACOL, V395, P547, DOI 10.1007/s00210-022-02204-8
   Rajendran Malathi, 2019, Front Biosci (Elite Ed), V11, P20
   Rauf A, 2024, FOOD SCI NUTR, V12, P675, DOI 10.1002/fsn3.3784
   Rizk FH, 2022, REDOX REP, V27, P177, DOI 10.1080/13510002.2022.2116551
   Sahu BD, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0105070
   Sandireddy R, 2016, CELL MOL NEUROBIOL, V36, P883, DOI 10.1007/s10571-015-0272-9
   Satari M, 2019, J CELL PHYSIOL, V234, P8522, DOI 10.1002/jcp.27801
   Scutiero G, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/7265238
   Seo HA, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/184598
   Seo SH, 2015, INT IMMUNOPHARMACOL, V29, P246, DOI 10.1016/j.intimp.2015.11.014
   Shen BY, 2021, MOLECULES, V26, DOI 10.3390/molecules26175306
   Shi YS, 2018, J AGR FOOD CHEM, V66, P8291, DOI 10.1021/acs.jafc.8b02140
   Sies H, 2017, REDOX BIOL, V11, P613, DOI 10.1016/j.redox.2016.12.035
   Singh S, 2018, LIFE SCI, V193, P171, DOI 10.1016/j.lfs.2017.11.004
   Solinas G, 2017, MOL METAB, V6, DOI 10.1016/j.molmet.2016.12.001
   Soysal Y, 2020, J BASIC CLIN HEALTH
   Sun Q, 2016, ALCOHOL CLIN EXP RES, V40, P2076, DOI 10.1111/acer.13172
   Tanase DM, 2022, BIOMOLECULES, V12, DOI 10.3390/biom12091227
   Ugan RA, 2023, AN ACAD BRAS CIENC, V95, DOI 10.1590/0001-3765202320201408
   Ullah A, 2020, MOLECULES, V25, DOI 10.3390/molecules25225243
   Wang TH, 2018, NEUROSCIENCE, V379, P152, DOI 10.1016/j.neuroscience.2018.03.008
   Wang YT, 2023, FOLIA NEUROPATHOL, V61, P196, DOI 10.5114/fn.2023.126893
   Watanabe M, 2015, J AGR FOOD CHEM, V63, P4979, DOI 10.1021/acs.jafc.5b00821
   Wu PY, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18102118
   Wu SJ, 2022, NUTRIENTS, V14, DOI 10.3390/nu14091841
   Xia YD, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11102067
   Xing XP, 2023, MOLECULES, V28, DOI 10.3390/molecules28145533
   Xu JL, 2012, DIABETES, V61, P3208, DOI 10.2337/db11-1716
   Xu MX, 2019, FOOD FUNCT, V10, P1302, DOI 10.1039/c8fo01615a
   Yagishita Y, 2017, CELL REP, V18, P2030, DOI 10.1016/j.celrep.2017.01.064
   Yan L, 2021, EXP THER MED, V21, DOI 10.3892/etm.2020.9457
   Yaribeygi H, 2019, J CELL PHYSIOL, V234, P8152, DOI 10.1002/jcp.27603
   Yaribeygi H, 2019, J CELL PHYSIOL, V234, P1300, DOI 10.1002/jcp.27164
   Yen JH, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18040852
   Yousefzadeh MJ, 2018, EBIOMEDICINE, V36, P18, DOI 10.1016/j.ebiom.2018.09.015
   Zhang HH, 2019, MOLECULES, V24, DOI 10.3390/molecules24040708
   Zhang L, 2018, NEUROCHEM INT, V118, P304, DOI 10.1016/j.neuint.2018.05.011
   Zhang P, 2021, INFLAMMATION, V44, P1490, DOI 10.1007/s10753-021-01434-x
   Zhang SS, 2020, FRONT NEUROSCI-SWITZ, V14, DOI 10.3389/fnins.2020.00241
   Zhao LC, 2019, PHYTOMEDICINE, V58, DOI 10.1016/j.phymed.2019.152865
   Zhao X, 2015, PHARMACOL RES, V102, P286, DOI 10.1016/j.phrs.2015.10.007
   Zou TF, 2023, ACTA PHARMACOL SIN, V44, P2065, DOI 10.1038/s41401-023-01106-6
NR 117
TC 2
Z9 2
U1 0
U2 0
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD DEC
PY 2024
VL 23
IS 2
BP 1753
EP 1771
DI 10.1007/s40200-024-01502-7
EA OCT 2024
PG 19
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA N4L5Z
UT WOS:001339713900002
PM 39610486
DA 2025-06-11
ER

PT J
AU Tomas, E
   Wood, JA
   Stanojevic, V
   Habener, JF
AF Tomas, E.
   Wood, J. A.
   Stanojevic, V.
   Habener, J. F.
TI Glucagon-like peptide-1(9-36)amide metabolite inhibits weight gain and
   attenuates diabetes and hepatic steatosis in diet-induced obese mice
SO DIABETES OBESITY & METABOLISM
LA English
DT Article
DE animal pharmacology; antidiabetic drug; antiobesity drug; diabetes
   mellitus; energy expenditure; energy regulation; GLP-1; insulin
   resistance; metabolic syndrome
ID HIGH-FAT DIET; INSULIN-RESISTANCE; PEPTIDE-1 RECEPTOR; NEUTRAL
   ENDOPEPTIDASE-24.11; TISSUE DISTRIBUTION; INCRETIN RECEPTORS;
   ENERGY-EXPENDITURE; GLUCOSE-PRODUCTION; OXIDATIVE STRESS; MOUSE MODEL
AB Aims: The metabolic syndrome, a disease arising from the world-wide epidemic of obesity, is manifested as severe insulin resistance, hyperlipidaemia, hepatic steatosis and diabetes. Previously we reported that GLP-1(9-36)amide, derived from the gluco-incretin hormone, glucagon-like peptide-1 (GLP-1), suppresses gluconeogenesis in isolated hepatocytes. The aims of this study were to determine the effects of GLP-1(9-36) amide in diet-induced obese mice that model the development of the metabolic syndrome.
   Methods: Mice rendered obese by feeding a very high fat diet were administered GLP-1(9-36) amide via subcutaneous osmopumps for 8 weeks. Body weight, energy intake, plasma insulin and glucose levels (insulin-resistance), and hepatic steatosis were assessed.
   Results: Eight-week infusions of GLP-1(9-36) amide inhibited weight gain, increased energy intake, prevented the development of fasting hyperinsulinaemia and hyperglycaemia, and curtailed the accumulation of liver triglycerides. The peptide had no effects in mice fed a normal chow diet. Notably, energy intake in the obese mice receiving GLP-1(9-36) amide was 20% greater than obese mice receiving vehicle control.
   Conclusions: GLP-1(9-36) amide exerts insulin-like actions in the presence of insulin resistance and prevents the development of metabolic syndrome. Curtailment of weight gain in the face of increased caloric intake suggests that GLP-1(9-36) amide increases energy expenditure. These findings suggest the possibility of the use of GLP-1(9-36) amide, or a peptide mimetic derived there from, for the treatment of obesity, insulin resistance and the metabolic syndrome.
C1 [Tomas, E.; Wood, J. A.; Stanojevic, V.; Habener, J. F.] Massachusetts Gen Hosp, Mol Endocrinol Lab, Boston, MA 02114 USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital
RP Habener, JF (corresponding author), Massachusetts Gen Hosp, Mol Endocrinol Lab, 55 Fruit St Wellman 306,Thier 306, Boston, MA 02114 USA.
EM Jhabener@partners.org
CR Abu-Hamdah R, 2009, J CLIN ENDOCR METAB, V94, P1843, DOI 10.1210/jc.2008-1296
   Aviv V, 2009, J BIOL CHEM, V284, P33509, DOI 10.1074/jbc.M109.017608
   Ban K, 2008, CIRCULATION, V117, P2340, DOI 10.1161/CIRCULATIONAHA.107.739938
   Ban K, 2010, ENDOCRINOLOGY, V151, P1520, DOI 10.1210/en.2009-1197
   Beck-Nielsen Henning, 2002, Curr Diab Rep, V2, P231
   Beinborn M, 2005, REGUL PEPTIDES, V130, P1, DOI 10.1016/j.regpep.2005.05.001
   BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911
   Brown MS, 1999, P NATL ACAD SCI USA, V96, P11041, DOI 10.1073/pnas.96.20.11041
   Bullock BP, 1996, ENDOCRINOLOGY, V137, P2968, DOI 10.1210/en.137.7.2968
   Deacon CF, 2004, HORM METAB RES, V36, P761, DOI 10.1055/s-2004-826160
   Dunphy JL, 1998, MOL CELL ENDOCRINOL, V141, P179, DOI 10.1016/S0303-7207(98)00096-3
   EAHI D, 2008, OBESITY, V16, P1501
   Flock G, 2007, DIABETES, V56, P3006, DOI 10.2337/db07-0697
   Grattagliano I, 2008, J NUTR BIOCHEM, V19, P491, DOI 10.1016/j.jnutbio.2007.06.011
   Green BD, 2008, ARCH BIOCHEM BIOPHYS, V478, P136, DOI 10.1016/j.abb.2008.08.001
   Haas JT, 2009, CURR OPIN LIPIDOL, V20, P206, DOI 10.1097/MOL.0b013e32832b2024
   Hansotia T, 2007, J CLIN INVEST, V117, P143, DOI 10.1172/JCI25483
   HUPESODMANN K, 1995, REGUL PEPTIDES, V58, P149, DOI 10.1016/0167-0115(95)00063-H
   Ikezawa Y, 2003, REGUL PEPTIDES, V111, P207, DOI 10.1016/S0167-0115(02)00287-2
   Kieffer TJ, 1999, ENDOCR REV, V20, P876, DOI 10.1210/er.20.6.876
   Knauf C, 2008, ENDOCRINOLOGY, V149, P4768, DOI 10.1210/en.2008-0180
   Lovshin JA, 2009, NAT REV ENDOCRINOL, V5, P262, DOI 10.1038/nrendo.2009.48
   Márquez L, 1998, CELL BIOCHEM FUNCT, V16, P51, DOI 10.1002/(SICI)1099-0844(199803)16:1<51::AID-CBF767>3.0.CO;2-T
   Nikolaidis LA, 2005, AM J PHYSIOL-HEART C, V289, pH2401, DOI 10.1152/ajpheart.00347.2005
   Parekh PI, 1998, METABOLISM, V47, P1089, DOI 10.1016/S0026-0495(98)90283-9
   Parlevliet ET, 2010, AM J PHYSIOL-ENDOC M, V299, pE318, DOI 10.1152/ajpendo.00191.2010
   Plamboeck A, 2005, DIABETOLOGIA, V48, P1882, DOI 10.1007/s00125-005-1847-7
   Raab EL, 2009, AM J PHYSIOL-REG I, V297, pR1785, DOI 10.1152/ajpregu.00519.2009
   Randle PJ, 1998, DIABETES METAB REV, V14, P263, DOI 10.1002/(SICI)1099-0895(199812)14:4<263::AID-DMR233>3.0.CO;2-C
   Roden M, 2001, RECENT PROG HORM RES, V56, P219, DOI 10.1210/rp.56.1.219
   Rolin B, 2004, EUR J PHARMACOL, V494, P283, DOI 10.1016/j.ejphar.2004.05.013
   Ryan AS, 1998, J CLIN ENDOCR METAB, V83, P2399, DOI 10.1210/jc.83.7.2399
   Samson SL, 2008, MOL THER, V16, P1805, DOI 10.1038/mt.2008.198
   Sonne DP, 2008, REGUL PEPTIDES, V146, P243, DOI 10.1016/j.regpep.2007.10.001
   Stein LL, 2009, ADV THER, V26, P893, DOI 10.1007/s12325-009-0072-z
   TAPPY L, 1995, DIABETES METAB, V21, P233
   Tomas E, 2010, HORM METAB RES, V42, P657, DOI 10.1055/s-0030-1253421
   Tomas E, 2010, TRENDS ENDOCRIN MET, V21, P59, DOI 10.1016/j.tem.2009.11.007
   Trapote MA, 1996, J ENDOCRINOL INVEST, V19, P114, DOI 10.1007/BF03349846
   Vahl TP, 2003, J CLIN ENDOCR METAB, V88, P1772, DOI 10.1210/jc.2002-021479
   VALVERDE I, 1994, FEBS LETT, V349, P313, DOI 10.1016/0014-5793(94)00699-7
   Watanabe S, 2008, J GASTROENTEROL, V43, P509, DOI 10.1007/s00535-008-2193-6
   Woo HN, 2009, BIOCHEM BIOPH RES CO, V390, P1093, DOI 10.1016/j.bbrc.2009.10.093
   Zhang J, 2007, DIABETOLOGIA, V50, P1900, DOI 10.1007/s00125-007-0737-6
NR 44
TC 39
Z9 53
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD JAN
PY 2011
VL 13
IS 1
BP 26
EP 33
DI 10.1111/j.1463-1326.2010.01316.x
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 686LQ
UT WOS:000284698200004
PM 21114600
DA 2025-06-11
ER

PT J
AU Muammer, K
   Mutluay, F
   Demir, R
   Özkan, AA
AF Muammer, Kiymet
   Mutluay, Fatma
   Demir, Rengin
   Ozkan, Alev Arat
TI Effects of peripheral and different inspiratory muscle training methods
   in coronary artery disease patients with metabolic syndrome: A
   randomized-controlled trial
SO RESPIRATORY MEDICINE
LA English
DT Article
DE Coronary artery disease; Metabolic syndrome; Neuromuscular electrical
   stimulation; Inspiratory muscle training; Peripheral muscle training
ID LUNG-FUNCTION; RESISTANCE EXERCISE; CARDIOVASCULAR RISK; STRENGTH;
   PREVALENCE; PARAMETERS; LIFE
AB Background
   Objective: To investigate the effects of peripheral muscle training (PMT) and different inspiratory muscle training (IMT) methods on respiratory functions, exercise capacity, and biochemistry parameters in coronary artery disease patients with metabolic syndrome.
   Methods: This prospective, single-blind, randomized-controlled study included 60 patients of stable coronary artery disease with metabolic syndrome (New York Heart Association [NYHA] Class I-II, left ventricular ejection fraction >40%). Patients were randomly divided into three groups: neuromuscular electrical stimulation (NMES) plus PMT group (NMES + PMT group, n = 20), IMT plus PMT group (IMT + PMT group, n = 20) and PMT group (PMT group, n = 20). Treatment continued for six weeks for all groups. The NMES was applied to rectus abdominis, IMT was applied with 30% of maximal inspiratory pressures, and PMT was applied at home. Spirometry, maximal inspiratory and expiratory pressure, dyspnea scores, exercise stress test, and biochemistry parameters were measured before and after training.
   Results: There were significant improvements in spirometric tests, respiratory muscle strength, dyspnea scores, exercise capacity, fasting blood glucose, and antistreptolysin O after treatment in all groups (p < 0.05). Significant improvements in C-reactive protein and erythrocyte sedimentation rate were observed in NMES + PMT and IMT + PMT groups (p < 0.05). Among the groups, there was a significant difference in maximal inspiratory pressure (p = 0.02) and erythrocyte sedimentation rate (p = 0.037) in favor of NMES + PMT group (p < 0.05).
   Conclusion: Our study results showed significant improvements in respiratory functions, exercise capacity, and biochemistry markers in all groups. Different IMT methods can be used in cardiopulmonary rehabilitation to improve exercise intolerance in coronary artery disease patients with metabolic syndrome.
C1 [Muammer, Kiymet; Demir, Rengin; Ozkan, Alev Arat] Istanbul Univ Cerrahpasa, Cardiol Inst, Dept Cardiol, Istanbul, Turkey.
   [Mutluay, Fatma] Medipol Univ, Fac Hlth Sci, Dept Physiotherapy & Rehabil, Istanbul, Turkey.
C3 Istanbul University - Cerrahpasa; Istanbul Medipol University
RP Mutluay, F (corresponding author), Ekinciler Cad 19 Kavacik Kavsagi Beykoz, TR-34810 Istanbul, Turkey.
EM fmutluay@medipol.edu.tr
RI MUTLUAY, Fatma/JVN-5548-2024; Mutluay, Fatma/G-1975-2015; Arat-Ozkan,
   Alev/A-8073-2016
OI Demir, Rengin/0000-0002-2901-2967; Mutluay, Fatma/0000-0003-1432-0913;
   Arat-Ozkan, Alev/0000-0001-8064-7231; Muammer,
   Kiymet/0000-0002-7640-7267
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Areas GPT, 2013, BRAZ J PHYS THER, V17, P541, DOI 10.1590/S1413-35552012005000131
   Bae MS, 2012, KOREAN J FAM MED, V33, P70, DOI 10.4082/kjfm.2012.33.2.70
   Baffi CW, 2016, CHEST, V149, P1525, DOI 10.1016/j.chest.2015.12.034
   Bakanligi T.S., 2012, TEST ONCESI VE SONRA
   Balducci S, 2010, NUTR METAB CARDIOVAS, V20, P608, DOI 10.1016/j.numecd.2009.04.015
   Bateman LA, 2011, AM J CARDIOL, V108, P838, DOI 10.1016/j.amjcard.2011.04.037
   BLACK LF, 1969, AM REV RESPIR DIS, V99, P696
   Breyer MK, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0098013
   Casella A, 2011, AM J CARDIOL, V107, P1168, DOI 10.1016/j.amjcard.2010.12.014
   Chen CH, 2014, KAOHSIUNG J MED SCI, V30, P521, DOI 10.1016/j.kjms.2014.08.004
   Clini E, 2013, INTERN EMERG MED, V8, P283, DOI 10.1007/s11739-011-0700-x
   Colombo CM, 2013, EINSTEIN-SAO PAULO, V11, P324, DOI 10.1590/S1679-45082013000300011
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Gayda M, 2016, CAN J CARDIOL, V32, P485, DOI 10.1016/j.cjca.2016.01.017
   Grundy SM, 2004, CIRCULATION, V110, P227, DOI 10.1161/01.CIR.0000133317.49796.0E
   Gutwenger Ivana, 2015, BMC Res Notes, V8, P103, DOI 10.1186/s13104-015-1066-3
   Hsiao FC, 2010, METABOLISM, V59, P848, DOI 10.1016/j.metabol.2009.10.001
   Liaw MY, 2011, CLIN REHABIL, V25, P524, DOI 10.1177/0269215510391682
   Lin Suh-Jen, 2012, Cardiopulm Phys Ther J, V23, P29
   Lin WY, 2006, OBESITY, V14, P1654, DOI 10.1038/oby.2006.190
   Liu CC, 2018, HEALTH QUAL LIFE OUT, V16, DOI 10.1186/s12955-018-0910-2
   MAHLER DA, 1988, CHEST, V93, P580, DOI 10.1378/chest.93.3.580
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Naveed B, 2012, AM J RESP CRIT CARE, V185, P392, DOI 10.1164/rccm.201109-1672OC
   Neves LF, 2014, RESP CARE, V59, P1381, DOI 10.4187/respcare.02793
   Park HY, 2010, RESP MED, V104, P1326, DOI 10.1016/j.rmed.2010.02.024
   Pattyn N, 2013, SPORTS MED, V43, P121, DOI 10.1007/s40279-012-0003-z
   Pellegrino R., 2005, EUR RESP J, V26
   Pérez IP, 2010, J CLIN HYPERTENS, V12, P374, DOI 10.1111/j.1751-7176.2009.00259.x
   Rogliani P, 2010, RESP MED, V104, P47, DOI 10.1016/j.rmed.2009.08.009
   Rubenfire M, 2011, J CARDIOPULM REHABIL, V31, P282, DOI 10.1097/HCR.0b013e318220a7eb
   Sadeghi M, 2016, J RES MED SCI, V21
   Tenório LHS, 2013, DISABIL REHABIL, V35, P1915, DOI 10.3109/09638288.2013.769635
   Sarti C, 2006, J DIABETES COMPLICAT, V20, P121, DOI 10.1016/j.jdiacomp.2005.06.014
   Savage PD, 2005, AM HEART J, V149, P627, DOI 10.1016/j.ahj.2004.07.037
   Scarlata S, 2013, GERIATR GERONTOL INT, V13, P894, DOI 10.1111/ggi.12026
   Spruit MA, 2013, AM J RESP CRIT CARE, V188, pE13, DOI 10.1164/rccm.201309-1634ST
   Stensvold D, 2010, J APPL PHYSIOL, V108, P804, DOI 10.1152/japplphysiol.00996.2009
   Stoller J K, 2005, Pneumologie, V59, P36, DOI 10.1055/s-2004-830176
   Wanger J, 2005, EUR RESPIR J, V26, P511, DOI 10.1183/09031936.05.00035005
   Wise FM, 2011, CLIN REHABIL, V25, P1059, DOI 10.1177/0269215511423408
NR 42
TC 5
Z9 7
U1 1
U2 10
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0954-6111
EI 1532-3064
J9 RESP MED
JI Respir. Med.
PD OCT
PY 2020
VL 172
AR 106119
DI 10.1016/j.rmed.2020.106119
PG 10
WC Cardiac & Cardiovascular Systems; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System
GA OD6UR
UT WOS:000579986900004
PM 32877886
OA Bronze
DA 2025-06-11
ER

PT J
AU Bowles, NP
   Hill, MN
   Bhagat, SM
   Karatsoreos, IN
   Hillard, CJ
   McEwen, BS
AF Bowles, N. P.
   Hill, M. N.
   Bhagat, S. M.
   Karatsoreos, I. N.
   Hillard, C. J.
   McEwen, B. S.
TI CHRONIC, NONINVASIVE GLUCOCORTICOID ADMINISTRATION SUPPRESSES LIMBIC
   ENDOCANNABINOID SIGNALING IN MICE
SO NEUROSCIENCE
LA English
DT Review
DE CB1; cannabinoid; 2-AG; anandamide; stress; corticosterone
ID N-ARACHIDONYLETHANOLAMINE ANANDAMIDE; CHRONIC UNPREDICTABLE STRESS;
   CANNABINOID RECEPTOR; CHRONIC CORTICOSTERONE; METABOLIC SYNDROME;
   RESTRAINT STRESS; BRAIN; SYSTEM; DEPRESSION; AMYGDALA
AB Limbic endocannabinoid signaling is known to be sensitive to chronic stress; however, studies investigating the impact of prolonged exposure to glucocorticoid hormones have been limited by the concurrent exposure to the stress of daily injections. The present study was designed to examine the effects of a noninvasive approach to alter plasma corticosterone (CORT) on the endocannabinoid system. More precisely, we explored the effects of a 4-week exposure to CORT dissolved in the drinking water of mice (100 mu g/ml) and measured cannabinoid CB1 receptor binding, endocannabinoid content, activity of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH), and mRNA expression of both the CB1 receptor and FAAH in both the hippocampus and amygdala. Our data demonstrate that CORT decreases CB1 receptor binding site density in both the hippocampus and amygdala and also reduced anandamide (AEA) content and increased FAAH activity within both structures. These changes in both CB1 receptor binding and FAAH activity were not accompanied by changes in mRNA expression of either the CB1 receptor or FAAH in either brain region. Interestingly, our CORT delivery regimen significantly increased 2-AG concentrations within the hippocampus, but not the amygdala. Collectively, these data demonstrate that the confounder of injection stress is sufficient to conceal the ability of protracted exposure to glucocorticoids to reduce CB1 receptor density and augment AEA metabolism within limbic structures.
   This article is part of a Special Issue entitled: Stress, Emotional Behavior and the Endocannabinoid System. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
C1 [Bowles, N. P.; Hill, M. N.; Bhagat, S. M.; Karatsoreos, I. N.; McEwen, B. S.] Rockefeller Univ, Neuroendocrinol Lab, New York, NY 10021 USA.
   [Hillard, C. J.] Med Coll Wisconsin, Dept Pharmacol & Toxicol, Milwaukee, WI 53226 USA.
C3 Rockefeller University; Medical College of Wisconsin
RP Bowles, NP (corresponding author), Rockefeller Univ, Neuroendocrinol Lab, New York, NY 10021 USA.
EM nbowles@rockefeller.edu
RI Hill, Matthew/J-4610-2013; Karatsoreos, Ilia/AAR-8774-2020; McEwen,
   Bruce/Z-1630-2019; Hillard, Cecilia/O-6693-2018
OI Bhagat, Sarah M/0000-0003-1108-6244; Hillard,
   Cecilia/0000-0002-9678-748X
FU NIMH NIH HHS [R01 MH041256, T32 MH015125] Funding Source: Medline
CR AHIMA RS, 1990, NEUROSCIENCE, V39, P579, DOI 10.1016/0306-4522(90)90244-X
   Bhagat SM, 2009, SOC NEUR ABSTR, V469, P23
   Chrousos GP, 2009, ANN NY ACAD SCI, V1179, P153, DOI 10.1111/j.1749-6632.2009.04988.x
   Deutsch DG, 2002, PROSTAG LEUKOTR ESS, V66, P201, DOI 10.1054/plef.2001.0358
   DEVANE WA, 1992, SCIENCE, V258, P1946, DOI 10.1126/science.1470919
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   Gorzalka BB, 2008, NEUROSCI BIOBEHAV R, V32, P1152, DOI 10.1016/j.neubiorev.2008.03.004
   Herman JP, 2003, FRONT NEUROENDOCRIN, V24, P151, DOI 10.1016/j.yfrne.2003.07.001
   Hill MN, 2008, J NEUROCHEM, V106, P2322, DOI 10.1111/j.1471-4159.2008.05567.x
   Hill MN, 2008, HIPPOCAMPUS, V18, P221, DOI 10.1002/hipo.20386
   Hill MN, 2010, J NEUROSCI, V30, P14980, DOI 10.1523/JNEUROSCI.4283-10.2010
   Hill MN, 2010, PSYCHONEUROENDOCRINO, V35, P1333, DOI 10.1016/j.psyneuen.2010.03.005
   Hill MN, 2010, PROG NEURO-PSYCHOPH, V34, P791, DOI 10.1016/j.pnpbp.2009.11.001
   Hill MN, 2010, P NATL ACAD SCI USA, V107, P9406, DOI 10.1073/pnas.0914661107
   Hill MN, 2005, EUR J PHARMACOL, V528, P99, DOI 10.1016/j.ejphar.2005.10.058
   Hill MN, 2005, NEUROPSYCHOPHARMACOL, V30, P508, DOI 10.1038/sj.npp.1300601
   HILLARD CJ, 1995, BBA-LIPID LIPID MET, V1257, P249, DOI 10.1016/0005-2760(95)00087-S
   Karatsoreos IN, 2010, ENDOCRINOLOGY, V151, P2117, DOI 10.1210/en.2009-1436
   Lutz B, 2009, CURR OPIN PHARMACOL, V9, P46, DOI 10.1016/j.coph.2008.12.001
   MAILLEUX P, 1993, NEUROSCI LETT, V156, P51, DOI 10.1016/0304-3940(93)90437-P
   MATSUDA LA, 1990, NATURE, V346, P561, DOI 10.1038/346561a0
   McEwen BS, 2007, PHYSIOL REV, V87, P873, DOI 10.1152/physrev.00041.2006
   MUNRO S, 1993, NATURE, V365, P61, DOI 10.1038/365061a0
   OMEIR RL, 1995, LIFE SCI, V56, P1999, DOI 10.1016/0024-3205(95)00181-5
   Patel S, 2005, EUR J NEUROSCI, V21, P1057, DOI 10.1111/j.1460-9568.2005.03916.x
   Patel S, 2005, J LIPID RES, V46, P342, DOI 10.1194/jlr.M400377-JLR200
   Patel S, 2009, NEUROPSYCHOPHARMACOL, V34, P2699, DOI 10.1038/npp.2009.101
   Pecoraro N, 2006, PROG NEUROBIOL, V79, P247, DOI 10.1016/j.pneurobio.2006.07.004
   Rademacher DJ, 2008, NEUROPHARMACOLOGY, V54, P108, DOI 10.1016/j.neuropharm.2007.06.012
   Reich CG, 2009, BEHAV BRAIN RES, V203, P264, DOI 10.1016/j.bbr.2009.05.013
   Schulkin Jay, 2006, Dialogues Clin Neurosci, V8, P407
   Steiner MA, 2008, PROG BRAIN RES, V170, P397, DOI 10.1016/S0079-6123(08)00433-0
   Sterner EY, 2010, PROG NEURO-PSYCHOPH, V34, P777, DOI 10.1016/j.pnpbp.2010.03.005
   SUGIURA T, 1995, BIOCHEM BIOPH RES CO, V215, P89, DOI 10.1006/bbrc.1995.2437
   Takeuchi T, 2009, DIABETES METAB, V35, P32, DOI 10.1016/j.diabet.2008.06.006
   Waleh NS, 2002, GENE, V291, P203, DOI 10.1016/S0378-1119(02)00598-X
NR 36
TC 48
Z9 58
U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
J9 NEUROSCIENCE
JI Neuroscience
PD MAR 1
PY 2012
VL 204
SI SI
BP 83
EP 89
DI 10.1016/j.neuroscience.2011.08.048
PG 7
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 906FT
UT WOS:000301331000009
PM 21939741
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Khalil, RG
   Atia, T
   Yousef, AI
   Sakr, HI
   Ahmed, OM
AF Khalil, Rehab G.
   Atia, Tarek
   Yousef, Ahmed I.
   Sakr, Hader Ibrahim
   Ahmed, Osama M.
TI Role of irisin in metabolic and cardiovascular disorders and its
   therapeutic potential
SO BENI-SUEF UNIVERSITY JOURNAL OF BASIC AND APPLIED SCIENCES
LA English
DT Review
DE Irisin; Obesity; Diabetes; Cardiovascular disorders; Molecular
   mechanism; Therapeutic role
ID IMPROVES ENDOTHELIAL FUNCTION; MESSENGER-RNA EXPRESSION; CIRCULATING
   IRISIN; ADIPOSE-TISSUE; INSULIN-RESISTANCE; SERUM-LEVELS;
   DIABETES-MELLITUS; OXIDATIVE STRESS; MYOKINE IRISIN; CELL-SURVIVAL
AB Irisin, a myokine produced by cleaving fibronectin type III domain-containing protein 5 (FNDC5), is a key regulator of metabolic processes and cardiovascular health. Its discovery in 2012 sparked significant interest due to its potential to impact fat and glucose metabolism, convert white fat to brown, and reduce inflammation-crucial in managing metabolic syndrome, obesity, and diabetes. Found in various tissues, including the brain, liver, heart, kidneys, and skeletal muscle, irisin has been linked to improved metabolic dysregulation and increased energy expenditure. Moreover, it has the potential to enhance endothelial function, reduce oxidative stress, and possibly regulate blood pressure, all contributing to improved cardiovascular health. This review explores the promising potential of irisin as a treatment for cardiovascular diseases (CVDs), metabolic syndrome, and related conditions. While more research is needed to fully understand its pathways, the future of irisin-based therapies in clinical settings looks promising.
C1 [Khalil, Rehab G.; Yousef, Ahmed I.; Ahmed, Osama M.] Beni Suef Univ, Fac Sci, Bani Suwayf, Egypt.
   [Atia, Tarek] Prince Sattam bin Abdulaziz Univ Al Kharj, Coll Appl Med Sci, Dept Med Labs, Al Kharj, Saudi Arabia.
   [Sakr, Hader Ibrahim] Cairo Univ, Fac Med, Dept Med Physiol, Cairo, Egypt.
   [Sakr, Hader Ibrahim] Batterjee Med Coll, Dept Med Physiol, Gen Med Practice Program, Jeddah 21442, Saudi Arabia.
C3 Egyptian Knowledge Bank (EKB); Beni Suef University; Prince Sattam Bin
   Abdulaziz University; Egyptian Knowledge Bank (EKB); Cairo University;
   Batterjee Medical College
RP Sakr, HI (corresponding author), Cairo Univ, Fac Med, Dept Med Physiol, Cairo, Egypt.; Sakr, HI (corresponding author), Batterjee Med Coll, Dept Med Physiol, Gen Med Practice Program, Jeddah 21442, Saudi Arabia.
EM rehab.khalil@science.bsu.edu.eg; t.mohamed@psau.edu.sa;
   ahmedismail_sc@yahoo.com; hadersakr@kasralainy.edu.eg;
   osama.ahmed@science.bsu.edu.eg
RI Sakr, Hader/AAC-1140-2022; Ahmed, Osama/P-8126-2018
CR Abd Al Jasem J., 2022, Med J Babylon, V19, P404, DOI [10.14744/SEMB.2022.62592, DOI 10.14744/SEMB.2022.62592, 10.4103/MJBL.MJBL5222, DOI 10.4103/MJBL.MJBL5222]
   Abo El Gheit RE, 2022, J PHYSIOL BIOCHEM, V78, P897, DOI 10.1007/s13105-022-00915-3
   Al-Ghazali Majid Jawad, 2020, Acta Biomed, V91, P56, DOI 10.23750/abm.v91i1.7675
   AL-Ghazali MJ, 2019, Acta Medica Iranica
   Aladag T, 2023, MINI-REV MED CHEM, V23, P1942, DOI 10.2174/1389557523666230411105506
   Aldulaimy A., 2024, Eur J Modern Med Practice, V4, P87
   Alzoughool F, 2022, PHARMACEUTICALS-BASE, V15, DOI 10.3390/ph15070863
   Amanat S, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.562895
   Anastasilakis AD, 2014, J CLIN ENDOCR METAB, V99, P3247, DOI 10.1210/jc.2014-1367
   Aronis KN, 2015, INT J OBESITY, V39, P156, DOI 10.1038/ijo.2014.101
   Askari H, 2018, PHARMACOL RES, V129, P44, DOI 10.1016/j.phrs.2018.01.012
   Avgerinos KI, 2023, METAB OPEN, V17, DOI 10.1016/j.metop.2023.100233
   Bellettini-Santos T, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms241512440
   Blüher S, 2014, OBESITY, V22, P1701, DOI 10.1002/oby.20739
   Bogdanet D, 2021, J CLIN MED, V10, DOI 10.3390/jcm10071533
   Boström P, 2012, NATURE, V481, P463, DOI 10.1038/nature10777
   Cai X, 2018, REPROD BIOMED ONLINE, V36, P172, DOI 10.1016/j.rbmo.2017.10.114
   Carmona-Maurici J, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24098171
   Celik H, 2023, SPORT SCI HLTH, V19, P597, DOI 10.1007/s11332-022-00924-1
   Celik N., 2020, Int J Med Biochem, V3, P91
   Chand S, 2024, LIFE SCI, V345, DOI 10.1016/j.lfs.2024.122607
   Chen K, 2022, FRONT PSYCHIATRY, V13, DOI 10.3389/fpsyt.2022.967683
   Chen N, 2016, DIABETES-METAB RES, V32, P51, DOI 10.1002/dmrr.2660
   Cheng ZB, 2021, CLIN CHIM ACTA, V522, P158, DOI 10.1016/j.cca.2021.08.022
   Chi C, 2022, EUR HEART J, V43, P4579, DOI 10.1093/eurheartj/ehac431
   Choi YK, 2013, DIABETES RES CLIN PR, V100, P96, DOI 10.1016/j.diabres.2013.01.007
   Codella R, 2015, EUR REV MED PHARMACO, V19, P3709
   Crujeiras AB, 2014, METABOLISM, V63, P520, DOI 10.1016/j.metabol.2013.12.007
   Crujeiras AB, 2014, AM J HUM BIOL, V26, P198, DOI 10.1002/ajhb.22493
   DiMeglio LA, 2018, LANCET, V391, P2449, DOI 10.1016/S0140-6736(18)31320-5
   Dokumacioglu E, 2020, EUR CYTOKINE NETW, V31, P39, DOI 10.1684/ecn.2020.0444
   Dong J, 2016, INT J OBESITY, V40, P434, DOI 10.1038/ijo.2015.200
   Drozdz D, 2023, PEDIATR NEPHROL, V38, P2973, DOI 10.1007/s00467-022-05802-z
   Duan HK, 2016, INT J BIOL MACROMOL, V84, P457, DOI 10.1016/j.ijbiomac.2015.12.049
   Eaton M, 2018, J SPORT HEALTH SCI, V7, P191, DOI 10.1016/j.jshs.2017.01.003
   Ebert T, 2014, CYTOKINE, V65, P153, DOI 10.1016/j.cyto.2013.11.009
   El-Said Z., 2022, Bull Egypt Soc Physiol Sci, V38, P53
   Espes D, 2015, DIABETIC MED, V32, P1172, DOI 10.1111/dme.12731
   Faienza MF, 2018, DIABETES RES CLIN PR, V141, P10, DOI 10.1016/j.diabres.2018.03.046
   Fu JJ, 2021, J AM HEART ASSOC, V10, DOI 10.1161/JAHA.121.022453
   Fu JJ, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.116.003433
   Gaowa A, 2024, Irisin promotes intestinal epithelial cell proliferation via Wnt/-Catenin and focal adhesion kinase signaling pathways
   Ghanbari-Niaki A, 2018, INTEGR MED RES, V7, P44, DOI 10.1016/j.imr.2018.01.007
   Gizaw M, 2017, J PHARMACOPUNCT, V20, P235, DOI [10.3831/KPI.2017.20.029, 10.3881/KPI.2017.20.4.002]
   Gonzalez DA, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1193110
   Gouni-Berthold I, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0072858
   Grimal P, 1987, The dictionary of classical mythology
   Grzeszczuk M, 2024, CELLS-BASEL, V13, DOI 10.3390/cells13030277
   Gunawardana SC, 2014, WORLD J DIABETES, V5, P420, DOI 10.4239/wjd.v5.i4.420
   Han C, 2022, EXP GERONTOL, V158, DOI 10.1016/j.exger.2021.111648
   Han F, 2015, AM J PHYSIOL-HEART C, V309, pH1501, DOI 10.1152/ajpheart.00443.2015
   He WY, 2020, SKELET MUSCLE, V10, DOI 10.1186/s13395-020-00245-2
   Ho MY, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10082103
   Huh JY, 2012, METABOLISM, V61, P1725, DOI 10.1016/j.metabol.2012.09.002
   Huo CJ, 2020, TOXICOL APPL PHARM, V394, DOI 10.1016/j.taap.2020.114953
   Imran M, 2024, PAK J MED SCI, V40, P115, DOI 10.12669/pjms.40.1.8140
   Jia J, 2019, WORLD J CLIN CASES, V7, P1444, DOI 10.12998/wjcc.v7.i12.1444
   Jiang S, 2021, BIOMOLECULES, V11, DOI 10.3390/biom11020322
   Jun LR, 2024, CURR NUTR REP, V13, P500, DOI 10.1007/s13668-024-00555-7
   Kahla H, 2024, EGYPT J INTERN MED, V36, DOI 10.1186/s43162-023-00250-z
   Kelly DP, 2012, SCIENCE, V336, P42, DOI 10.1126/science.1221688
   Khajebishak Y, 2023, J ASEAN FED ENDOCR S, V38, P45, DOI 10.15605/jafes.038.01.13
   Khorasani ZM, 2022, ENDOCRIN DIAB METAB, V5, DOI 10.1002/edm2.370
   Kim SJ, 2020, J EXERC REHABIL, V16, P265, DOI 10.12965/jer.2040334.167
   Korta P, 2019, MEDICINA-LITHUANIA, V55, DOI 10.3390/medicina55080485
   Kulhan NG, 2019, TAIWAN J OBSTET GYNE, V58, P434, DOI 10.1016/j.tjog.2019.01.027
   Kumar A., 2021, ALZHEIMER DIS NURSIN
   Kurdiova T, 2014, PEPTIDES, V56, P1, DOI 10.1016/j.peptides.2014.03.003
   Lascar N, 2018, LANCET DIABETES ENDO, V6, P69, DOI 10.1016/S2213-8587(17)30186-9
   Leung WKC, 2018, J DIABETES RES, V2018, DOI 10.1155/2018/8956509
   Leustean L, 2021, APPL SCI-BASEL, V11, DOI 10.3390/app11125579
   Li H, 2021, INT J ENDOCRINOL, V2021, DOI 10.1155/2021/6572342
   Li JM, 2020, AM J TRANSL RES, V12, P6003
   Li RL, 2024, INT J BIOL SCI, V20, P680, DOI 10.7150/ijbs.84153
   Li RL, 2018, J MOL CELL CARDIOL, V121, P242, DOI 10.1016/j.yjmcc.2018.07.250
   Li TR, 2023, DIABETOL METAB SYNDR, V15, DOI 10.1186/s13098-023-01216-5
   Lin JJ, 2024, SCI REP-UK, V14, DOI 10.1038/s41598-024-61415-6
   Lingvay I, 2022, LANCET, V399, P394, DOI 10.1016/S0140-6736(21)01919-X
   Liu C, 2022, J CARDIOVASC DEV DIS, V9, DOI 10.3390/jcdd9090305
   Liu JJ, 2013, J DIABETES COMPLICAT, V27, P365, DOI 10.1016/j.jdiacomp.2013.03.002
   Liu JY, 2019, MED SCI MONITOR, V25, P6085, DOI 10.12659/MSM.917625
   Liu JY, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-33229-w
   Liu RJ, 2021, BMC PLANT BIOL, V21, DOI 10.1186/s12870-021-03004-7
   Liu SQ, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.962968
   Liu SW, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0175498
   Liu TY, 2015, CLIN SCI, V129, P839, DOI 10.1042/CS20150009
   Llanos P, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11244008
   Löffler D, 2015, J CLIN ENDOCR METAB, V100, P1289, DOI 10.1210/jc.2014-2932
   Lopez EO, 2023, StatPearls Internet
   Lourenco MV, 2019, NAT MED, V25, P165, DOI 10.1038/s41591-018-0275-4
   Lu CS, 2024, PHYTOMEDICINE, V123, DOI 10.1016/j.phymed.2023.155217
   Lu JY, 2015, ATHEROSCLEROSIS, V243, P438, DOI 10.1016/j.atherosclerosis.2015.10.020
   Lu LH, 2020, CLIN TRANSL MED, V10, DOI 10.1002/ctm2.166
   Machado SA, 2022, NUTR METAB, V19, DOI 10.1186/s12986-022-00694-0
   Mahgoub MO, 2018, PEPTIDES, V104, P15, DOI 10.1016/j.peptides.2018.03.018
   Mahgoub MOS, 2018, Biochemical and biological effects of irisin in a model of diabetes mellitus
   Malik A, 2017, Congestive heart failure
   Moreno-Navarrete JM, 2013, J CLIN ENDOCR METAB, V98, pE769, DOI 10.1210/jc.2012-2749
   Marrano N, 2021, BIOMOLECULES, V11, DOI 10.3390/biom11020286
   Mazur-Bialy AI, 2018, J PHYSIOL PHARMACOL, V69, P117, DOI 10.26402/jpp.2018.1.13
   Miyamoto-Mikami E, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0120354
   Mozaffaritabar S, 2024, J PHYSIOL BIOCHEM, V80, P329, DOI 10.1007/s13105-024-01006-1
   Mu Y, 2021, REPROD BIOL ENDOCRIN, V19, DOI 10.1186/s12958-021-00821-1
   Nadimi H, 2019, REP BIOCHEM MOL BIOL, V8, P236
   Natalicchio A, 2017, DIABETES, V66, P2849, DOI 10.2337/db17-0002
   Neumayr G, 2021, INT J SPORTS MED, V42, P703, DOI 10.1055/a-1297-4669
   Nigro E, 2017, CYTOKINE, V94, P8, DOI 10.1016/j.cyto.2016.12.018
   Nurmohamed NS, 2024, European Heart Journal
   Ojha N, 2023, StatPearls Internet
   Onat T, 2021, Z GEBURTSH NEONATOL, V225, P320, DOI 10.1055/a-1404-4323
   Ou-Yang WL, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.678309
   Overby HB, 2019, Exploring novel anti-obesity strategies: nutritional and pharmacological interventions to induce browning and brown adipogenesis
   Bonfante ILP, 2017, ARCH ENDOCRIN METAB, V61, P524, DOI 10.1590/2359-3997000000305
   Pan JA, 2021, AM J MED SCI, V362, P63, DOI 10.1016/j.amjms.2021.02.020
   Pang BPS, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10020179
   Pang YL, 2017, EXP CELL RES, V360, P199, DOI 10.1016/j.yexcr.2017.09.006
   Park KH, 2013, J CLIN ENDOCR METAB, V98, P4899, DOI 10.1210/jc.2013-2373
   Parkin RA, 2024, FRONT REPROD HEALTH, V6, DOI 10.3389/frph.2024.1355922
   Perakakis N, 2017, NAT REV ENDOCRINOL, V13, P324, DOI 10.1038/nrendo.2016.221
   Pignataro P, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22041605
   Pinkas M, 2024, ANTIOXIDANTS-BASEL, V13, DOI 10.3390/antiox13040413
   Planella-Farrugia C, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00871
   Polyzos SA, 2018, ENDOCRINE, V59, P260, DOI 10.1007/s12020-017-1476-1
   Polyzos SA, 2015, METABOLISM, V64, P1611, DOI 10.1016/j.metabol.2015.09.001
   Qi JY, 2022, BRAIN RES BULL, V188, P11, DOI 10.1016/j.brainresbull.2022.07.007
   Qin SG, 2022, FRONT PHYSIOL, V13, DOI 10.3389/fphys.2022.935772
   Qiu SH, 2016, METABOLISM, V65, P825, DOI 10.1016/j.metabol.2016.02.006
   Raafat NA., 2024, Zagazig Univ Med J, V30, P347
   Ramesh S, 2023, AIMS NEUROSCI, V10, P200, DOI 10.3934/Neuroscience.2023017
   Remuzgo-Martinez S, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.894171
   Roca-Rivada A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0060563
   Roden M, 2019, NATURE, V576, P51, DOI 10.1038/s41586-019-1797-8
   Rodríguez A, 2017, ACTA PHYSIOL, V219, P362, DOI 10.1111/apha.12686
   Roggio F, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24065126
   Rostamian Mashhadi M, 2024, Sport Sciences for Health, P1
   Ruszala M, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222111578
   Sadier NS, 2024, LIFE SCI, V339, DOI 10.1016/j.lfs.2023.122393
   Sahoo Devadarshini, 2022, Indian J Endocrinol Metab, V26, P61, DOI 10.4103/ijem.ijem_466_21
   Sánchez B, 2022, EXPERT REV MOL MED, V25, DOI 10.1017/erm.2022.41
   Schumacher MA, 2013, J BIOL CHEM, V288, P33738, DOI 10.1074/jbc.M113.516641
   Seo DY, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17113863
   Shen SN, 2022, DRUG DISCOV TODAY, V27, P2261, DOI 10.1016/j.drudis.2022.03.019
   Shim YS, 2018, ENDOCR J, V65, P23, DOI 10.1507/endocrj.EJ17-0260
   Shimba Y, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-40643-1
   So WY, 2016, INT J BIOCHEM CELL B, V78, P237, DOI 10.1016/j.biocel.2016.07.022
   Steven S, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/7092151
   Sun HJ, 2020, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.01568
   Sun YJ, 2024, INT J BIOL MACROMOL, V265, DOI 10.1016/j.ijbiomac.2024.130857
   Tackling G, 2023, StatPearls Internet
   Tang H, 2016, EBIOMEDICINE, V6, P139, DOI 10.1016/j.ebiom.2016.02.041
   Tang YJ, 2024, CARDIOVASC DIABETOL, V23, DOI 10.1186/s12933-024-02183-5
   Tentolouris A, 2018, HORM METAB RES, V50, P803, DOI 10.1055/a-0748-6170
   Teufel A, 2002, GENE, V297, P79, DOI 10.1016/S0378-1119(02)00828-4
   Tibana RA, 2017, J NUTR HEALTH AGING, V21, P241, DOI 10.1007/s12603-016-0748-4
   Torabi A, 2024, INT J PREVENTIVE MED, V15, DOI 10.4103/ijpvm.ijpvm_76_23
   Tsiani E, 2021, CANCERS, V13, DOI 10.3390/cancers13112628
   Tsiloulis T, 2015, PROG MOL BIOL TRANSL, V135, P175, DOI 10.1016/bs.pmbts.2015.06.016
   Tu TQ, 2020, STEM CELLS DEV, V29, P533, DOI 10.1089/scd.2019.0232
   Vamvini MT, 2013, EUR J ENDOCRINOL, V169, P829, DOI 10.1530/EJE-13-0276
   Villarroya F, 2012, CELL METAB, V15, P277, DOI 10.1016/j.cmet.2012.02.010
   Vliora M, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23179971
   Wang C, 2023, FRONT NUTR, V9, DOI 10.3389/fnut.2022.1034443
   Wang P, 2018, DIABETES RES CLIN PR, V142, P130, DOI 10.1016/j.diabres.2018.05.038
   Wang PW, 2022, ATHEROSCLEROSIS, V346, P36, DOI 10.1016/j.atherosclerosis.2022.02.007
   Wang SS, 2024, FRONT ENDOCRINOL, V15, DOI 10.3389/fendo.2024.1337995
   Waseem R, 2022, MOLECULES, V27, DOI 10.3390/molecules27031118
   Zarei MA, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-022-26700-2
   Zebrowska A, 2020, THER ADV ENDOCRINOL, V11, DOI 10.1177/2042018820925326
   Zeng T, 2024, EXP CLIN ENDOCR DIAB, V132, P152, DOI 10.1055/a-2250-7830
   Zhang D, 2018, CELL PHYSIOL BIOCHEM, V51, P924, DOI 10.1159/000495395
   Zhang DG, 2020, ONCOTARGETS THER, V13, P4423, DOI 10.2147/OTT.S245178
   Zhang TD, 2024, BIOMED PHARMACOTHER, V175, DOI 10.1016/j.biopha.2024.116631
   Zhang Y, 2022, Heliyon, V8
   Zhang Y, 2014, DIABETES, V63, P514, DOI 10.2337/db13-1106
   Zhang YZ, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0158038
   Zhao RQ, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.989135
   Zheng XD, 2021, IMMUNOBIOLOGY, V226, DOI 10.1016/j.imbio.2021.152135
   Zhu D, 2022, DIABETES RES CLIN PR, V183, DOI 10.1016/j.diabres.2021.109170
   Zhu D, 2015, J MOL CELL CARDIOL, V87, P138, DOI 10.1016/j.yjmcc.2015.07.015
   Zou TD, 2021, NUTRITION, V90, DOI 10.1016/j.nut.2021.111263
NR 180
TC 0
Z9 0
U1 1
U2 1
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2314-8543
J9 BENI-SUEF U J BASIC
JI Beni-Suef Univ. J. Basic Appl. Sci.
PD MAY 30
PY 2025
VL 14
IS 1
AR 55
DI 10.1186/s43088-025-00643-9
PG 18
WC Multidisciplinary Sciences
WE Emerging Sources Citation Index (ESCI)
SC Science & Technology - Other Topics
GA 3FQ9U
UT WOS:001499214700002
DA 2025-06-11
ER

PT J
AU Knight, JM
   Avery, EF
   Janssen, I
   Powell, LH
AF Knight, Jennifer M.
   Avery, Elizabeth F.
   Janssen, Imke
   Powell, Lynda H.
TI Cortisol and Depressive Symptoms in a Population-Based Cohort of Midlife
   Women
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE diurnal cortisol; depressive symptoms; midlife women; women's health
ID MENOPAUSAL TRANSITION; METABOLIC SYNDROME; SALIVARY CORTISOL; MAJOR
   DEPRESSION; LATE-LIFE; STRESS; MOOD; RISK; PREMENOPAUSAL; DISEASE
AB Objective: To determine whether there is a relationship between depressive symptoms and cortisol assessed at first morning awakening, 6 PM, and 9 PM in a population-based sample of midlife women. If this relationship is not linear, we aim to test whether this relationship is nonlinear, only present in those with more severe depressive symptoms, better accounted for by diurnal slope, or only apparent under uncontaminated conditions. Methods: We investigated the cross-sectional association between cortisol and depressive symptoms, assessed by the Center for Epidemiological Studies Depression scale (CES-D) in 408 midlife women (45.7% African Americans, 54.3% white; mean age, 50.4 years) participating in the Chicago site of the Study of Women's Health Across the Nation. Results: Diurnal cortisol slope is significantly flatter for women with higher CES-D scores than for less depressed women (p < .05 for the interaction). This relationship remains significant even after adjusting for age, smoking status, race, education, income, menopausal status, hormone replacement therapy, body mass index, medications, and wake time, as well as possibly contaminating factors, including physical activity, smoking, eating, or caffeine or alcohol consumption before saliva collection. Results using depression assessed categorically (CES-D cutoff >= 16) were similar to those using continuous depression in both unadjusted and adjusted analyses (p = .005 for the interaction of CES-D by time). Conclusions: In this population-based sample of midlife women, greater depressive symptoms were associated with a significantly flatter diurnal cortisol slope than those with fewer symptoms, even after adjusting for covariates and possibly contaminating behaviors.
C1 [Knight, Jennifer M.] Rush Univ, Med Ctr, Dept Internal Med, Chicago, IL 60612 USA.
   [Knight, Jennifer M.] Rush Univ, Med Ctr, Dept Psychiat, Chicago, IL 60612 USA.
   [Avery, Elizabeth F.; Janssen, Imke; Powell, Lynda H.] Rush Univ, Med Ctr, Dept Prevent Med, Chicago, IL 60612 USA.
C3 Rush University; Rush University; Rush University
RP Knight, JM (corresponding author), Univ Rochester, Med Ctr, Dept Psychiat, 300 Crittenden Blvd, Rochester, NY 14642 USA.
EM Jennifer_Knight@urmc.rochester.edu
OI Knight, Jennifer/0000-0002-9140-3109; Janssen, Imke/0000-0003-1184-2812
FU National Institutes of Health (NIH); Department of Health and Human
   Services, through the National Institute on Aging (NIA); National
   Institute of Nursing Research (NINR); NIH Office of Research on Women's
   Health (ORWH) [NR004061, AG012505, AG012535, AG012531, AG012539,
   AG012546, AG012553, AG012554, AG012495]; National Heart, Lung and Blood
   Institute (NHLBI) [HL067128]; Charles J. and Margaret Roberts Trust
FX The Study of Women's Health Across the Nation (SWAN) has received grant
   support from the National Institutes of Health (NIH), Department of
   Health and Human Services, through the National Institute on Aging
   (NIA), the National Institute of Nursing Research (NINR), and the NIH
   Office of Research on Women's Health (ORWH) (Grants NR004061; AG012505,
   AG012535, AG012531, AG012539, AG012546, AG012553, AG012554, AG012495).
   The SWAN Fat Patterning Study is supported by Grant HL067128 from the
   National Heart, Lung and Blood Institute (NHLBI) and the Charles J. and
   Margaret Roberts Trust.
CR Bao AM, 2008, BRAIN RES REV, V57, P531, DOI 10.1016/j.brainresrev.2007.04.005
   BARDEN N, 1995, TRENDS NEUROSCI, V18, P6, DOI 10.1016/0166-2236(95)93942-Q
   Bhattacharyya MR, 2008, J PSYCHOSOM RES, V65, P107, DOI 10.1016/j.jpsychores.2008.03.012
   Birkhäuser M, 2002, MATURITAS, V41, pS3
   Bremmer MA, 2007, BIOL PSYCHIAT, V62, P479, DOI 10.1016/j.biopsych.2006.11.033
   Breslau N, 2006, ANN NY ACAD SCI, V1071, P221, DOI 10.1196/annals.1364.017
   Bromberger JT, 2001, AM J PUBLIC HEALTH, V91, P1435, DOI 10.2105/AJPH.91.9.1435
   Burke HM, 2005, PSYCHONEUROENDOCRINO, V30, P846, DOI 10.1016/j.psyneuen.2005.02.010
   CARROLL BJ, 1976, ARCH GEN PSYCHIAT, V33, P1051
   Cohen LS, 2006, ARCH GEN PSYCHIAT, V63, P385, DOI 10.1001/archpsyc.63.4.385
   Conrad A, 2008, J PSYCHIATR RES, V42, P769, DOI 10.1016/j.jpsychires.2007.08.003
   Deuschle M, 1997, J CLIN ENDOCR METAB, V82, P234, DOI 10.1210/jc.82.1.234
   DRESSENDORFER RA, 1992, J STEROID BIOCHEM, V43, P683, DOI 10.1016/0960-0760(92)90294-S
   Eskandari F, 2007, ARCH INTERN MED, V167, P2329, DOI 10.1001/archinte.167.21.2329
   Everson-Rose SA, 2009, PSYCHOSOM MED, V71, P410, DOI 10.1097/PSY.0b013e3181a20c9c
   Fiocco AJ, 2006, STRESS, V9, P143, DOI 10.1080/10253890600965674
   Gallagher-Thompson D, 2006, AM J GERIAT PSYCHIAT, V14, P334, DOI 10.1097/01.JGP.0000206485.73618.87
   GOLD PW, 1988, NEW ENGL J MED, V319, P413, DOI 10.1056/NEJM198808183190706
   Grant MM, 2007, ARCH WOMEN MENT HLTH, V10, P73, DOI 10.1007/s00737-007-0171-2
   Hansen ÅM, 2008, SCAND J CLIN LAB INV, V68, P448, DOI 10.1080/00365510701819127
   Holsboer F, 2000, NEUROPSYCHOPHARMACOL, V23, P477, DOI 10.1016/S0893-133X(00)00159-7
   Inslicht SS, 2006, PSYCHONEUROENDOCRINO, V31, P825, DOI 10.1016/j.psyneuen.2006.03.007
   Irwin MR, 2007, BRAIN BEHAV IMMUN, V21, P374, DOI 10.1016/j.bbi.2007.01.010
   Janssen I, 2008, ARCH INTERN MED, V168, P1568, DOI 10.1001/archinte.168.14.1568
   KANNEL WB, 1976, ANN INTERN MED, V85, P447, DOI 10.7326/0003-4819-85-4-447
   KOCSIS JH, 1984, BIOL PSYCHIAT, V19, P1255
   Kudielka BM, 2009, PSYCHONEUROENDOCRINO, V34, P2, DOI 10.1016/j.psyneuen.2008.10.004
   LINKOWSKI P, 1985, J CLIN ENDOCR METAB, V61, P429, DOI 10.1210/jcem-61-3-429
   O'Donnell K, 2008, PSYCHONEUROENDOCRINO, V33, P601, DOI 10.1016/j.psyneuen.2008.01.015
   Otte C, 2004, BIOL PSYCHIAT, V56, P241, DOI 10.1016/j.biopsych.2004.06.003
   Pariante CM, 2001, BIOL PSYCHIAT, V49, P391, DOI 10.1016/S0006-3223(00)01088-X
   Penninx BWJH, 2007, AM J GERIAT PSYCHIAT, V15, P522, DOI 10.1097/JGP.0b013e318033ed80
   Powell LH, 2002, PSYCHOSOM MED, V64, P502, DOI 10.1097/00006842-200205000-00015
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   SACHAR EJ, 1976, ANNU REV MED, V27, P389, DOI 10.1146/annurev.me.27.020176.002133
   Sephton SE, 2009, BRAIN BEHAV IMMUN, V23, P1148, DOI 10.1016/j.bbi.2009.07.007
   Sowers M., 2000, MENOPAUSE BIOL PATHO
   Strickland PL, 2002, BRIT J PSYCHIAT, V180, P168, DOI 10.1192/bjp.180.2.168
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
   vanEck M, 1996, PSYCHOSOM MED, V58, P447, DOI 10.1097/00006842-199609000-00007
   Vogelzangs N, 2007, PSYCHONEUROENDOCRINO, V32, P151, DOI 10.1016/j.psyneuen.2006.11.009
   Vreeburg SA, 2009, ARCH GEN PSYCHIAT, V66, P617, DOI 10.1001/archgenpsychiatry.2009.50
   Whitehead DL, 2007, J PSYCHOSOM RES, V62, P419, DOI 10.1016/j.jpsychores.2006.11.005
   Wichers MC, 2008, PSYCHOSOM MED, V70, P314, DOI 10.1097/PSY.0b013e31816b1eee
   Woods NF, 2008, MENOPAUSE, V15, P223, DOI 10.1097/gme.0b013e3181450fc2
NR 45
TC 41
Z9 48
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD NOV-DEC
PY 2010
VL 72
IS 9
BP 855
EP 861
DI 10.1097/PSY.0b013e3181f4ab87
PG 7
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 685ZA
UT WOS:000284665400004
PM 20841562
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Olijhoek, JK
   Hajer, GR
   van der Graaf, Y
   Dallinga-Thie, GM
   Visseren, FLJ
AF Olijhoek, Jobien K.
   Hajer, Gideon R.
   van der Graaf, Yolanda
   Dallinga-Thie, Geesje M.
   Visseren, Frank L. J.
TI The effects of low-dose simvastatin and ezetimibe compared to high-dose
   simvastatin alone on post-fat load endothelial function in patients with
   metabolic syndrome: A randomized double-blind crossover trial
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
LA English
DT Article
DE metabolic syndrome; statins; ezetimibe; postprandial lipid profiles;
   endothelial function
ID C-REACTIVE PROTEIN; SHORT-TERM; HYPERCHOLESTEROLEMIC PATIENTS;
   INSULIN-RESISTANCE; VASCULAR FUNCTION; OXIDATIVE STRESS; CHOLESTEROL;
   THERAPY; ATHEROSCLEROSIS; DYSFUNCTION
AB Background and Aims: Insulin resistance is associated with postprandial hyperlipidemia and endothelial dysfunciton. Patients with metabolic syndrome, characterized by insulin resistance, are at increased cardiovascular risk. The aim of the present study was to investigate wheather a similar low-density lipoprotein cholesterol (LDL-c) reduction with combination therapy of low-dose simvastatin and ezetimibe or with high-dose simvastatin alone has similar effects on (post-fat load) endothelial function.
   Methods: Randomized, double blind, crossover trial in 19 male obese patients with metabolic syndrome with high-dose simvastatin 80 mg versus combination therapy of low-dose simvastatin 10 mg with ezerimibe 10 mg. Fasting and post-fat load lipids and endothelial function (brachial artery flow-mediated dilation) were determined.
   Results: Fasting LDL-c concentrations (2.1 +/- 0.5 mmol/L) and fasting endothelial function (6.9 +/- 0.8 vs. 7.6 +/- 1.2%) were the same after both treatments. Although post-fat load plasma triglycerides concentrations were highr (3.2 +/- 0.4 vs. 2.6 +/- 0.2 mmol.h/L) with combination therapy compared to monotherapy, ApoB particles were comparable (0.9 +/- 3.3 vs. -0.2 +/- 2.3 g.h/L). Combination therapy did not decrease post-fat load endothelial function (7.6 +/- 1.2 vs. 7.7 +/- 1.6%) contrary to high-dose simvcastatin monotherapy (6.9 +/- 7.7 +/- 1.6%).
   conclusions: Combination therapy with low-dose simvastatin and ezetimibe preserved post-fat load endothelial function, contrary to treatment with high-dose simvastatin monotherapy in male metabolic syndrome patients. There were no differences in fasting lipid profiles and endothelial function.
C1 [van der Graaf, Yolanda] UMC Utrecht, Julius Ctr Hlth Sci & Primary Care, Amsterdam, Netherlands.
   [Dallinga-Thie, Geesje M.] Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, Lab Expt Vasc Med, NL-1105 AZ Amsterdam, Netherlands.
   [Olijhoek, Jobien K.; Hajer, Gideon R.; Visseren, Frank L. J.] UMC Utrecht, Dept Vasc Med, Amsterdam, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam
RP Visseren, FLJ (corresponding author), UMC Utrecht, Sect Vasc Med, F02-126 Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands.
EM f.l.j.visseren@umcutrecht.nl
RI Visseren, Frank/I-4855-2013
OI dallinga-thie, geesje/0000-0001-5412-5923; Visseren,
   Frank/0000-0003-3951-5223
CR Altmann SW, 2004, SCIENCE, V303, P1201, DOI 10.1126/science.1093131
   Baron AD, 1999, AM J CARDIOL, V84, p25J
   BATAILLE R, 1992, ARTHRITIS RHEUM-US, V35, P982, DOI 10.1002/art.1780350824
   Bulut D, 2005, CARDIOLOGY, V104, P176, DOI 10.1159/000088105
   Cannon CP, 2004, NEW ENGL J MED, V350, P1495, DOI 10.1056/NEJMoa040583
   Ceriello A, 2002, CIRCULATION, V106, P1211, DOI 10.1161/01.CIR.0000027569.76671.A8
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Davidson MH, 2002, J AM COLL CARDIOL, V40, P2125, DOI 10.1016/S0735-1097(02)02610-4
   de Graaf J, 2007, J CLIN ENDOCR METAB, V92, P1269, DOI 10.1210/jc.2006-1973
   Evans M, 2000, CIRCULATION, V101, P1773, DOI 10.1161/01.CIR.101.15.1773
   Fichtlscherer S, 2006, EUR HEART J, V27, P1182, DOI 10.1093/eurheartj/ehi881
   Funada J, 2004, ATHEROSCLEROSIS, V172, P151, DOI 10.1016/j.atherosclerosis.2003.09.016
   Grieve DJ, 1998, ATHEROSCLEROSIS, V139, P273, DOI 10.1016/S0021-9150(98)00078-1
   Hulthe J, 2000, ARTERIOSCL THROM VAS, V20, P2140, DOI 10.1161/01.ATV.20.9.2140
   Hulthe J, 2003, METABOLISM, V52, P1612, DOI 10.1016/S0026-0495(03)00313-5
   Huptas S, 2006, AM J CARDIOL, V98, P66, DOI 10.1016/j.amjcard.2006.01.055
   Johanson EH, 2004, J INTERN MED, V255, P273, DOI 10.1046/j.1365-2796.2003.01281.x
   John S, 1998, CIRCULATION, V98, P211, DOI 10.1161/01.CIR.98.3.211
   Kamalesh M, 2006, AM J CARDIOL, V97, P1487, DOI 10.1016/j.amjcard.2005.11.083
   Kosoglou T, 2005, CLIN PHARMACOKINET, V44, P467, DOI 10.2165/00003088-200544050-00002
   Kugiyama K, 1998, CIRCULATION, V97, P2519, DOI 10.1161/01.CIR.97.25.2519
   Landmesser U, 2005, CIRCULATION, V111, P2356, DOI 10.1161/01.CIR.0000164260.82417.3F
   Maggi FM, 2004, J CLIN ENDOCR METAB, V89, P2946, DOI 10.1210/jc.2003-031977
   Martens FMAC, 2005, J CARDIOVASC PHARM, V46, P773, DOI 10.1097/01.fjc.0000187176.13403.05
   Pocock SJ, 1983, CLIN TRIALS PRACTICA
   Sager PT, 2005, ATHEROSCLEROSIS, V179, P361, DOI 10.1016/j.atherosclerosis.2004.10.021
   STROES ESG, 1995, LANCET, V346, P467, DOI 10.1016/S0140-6736(95)91322-X
   Tan KCB, 2004, J CLIN ENDOCR METAB, V89, P765, DOI 10.1210/jc.2003-031012
   Tremblay AJ, 2006, ARTERIOSCL THROM VAS, V26, P1101, DOI 10.1161/01.ATV.0000216750.09611.ec
   Twickler TB, 2003, J CLIN ENDOCR METAB, V88, P1228, DOI 10.1210/jc.2002-020470
   Wheatcroft SB, 2003, DIABETIC MED, V20, P255, DOI 10.1046/j.1464-5491.2003.00869.x
NR 31
TC 41
Z9 45
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0160-2446
EI 1533-4023
J9 J CARDIOVASC PHARM
JI J. Cardiovasc. Pharmacol.
PD AUG
PY 2008
VL 52
IS 2
BP 145
EP 150
DI 10.1097/FJC.0b013e31817ffe76
PG 6
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 342QG
UT WOS:000258798000005
PM 18670365
OA Bronze
DA 2025-06-11
ER

PT J
AU Camargo, A
   Meneses, ME
   Rangel-Zuñiga, OA
   Perez-Martinez, P
   Marin, C
   Delgado-Lista, J
   Paniagua, JA
   Tinahones, FJ
   Roche, H
   Malagon, MM
   Perez-Jimenez, F
   Lopez-Miranda, J
AF Camargo, Antonio
   Meneses, Maria E.
   Rangel-Zuniga, Oriol A.
   Perez-Martinez, Pablo
   Marin, Carmen
   Delgado-Lista, Javier
   Paniagua, Juan A.
   Tinahones, Francisco J.
   Roche, Helen
   Malagon, Maria M.
   Perez-Jimenez, Francisco
   Lopez-Miranda, Jose
TI Endoplasmic reticulum stress in adipose tissue determines postprandial
   lipoprotein metabolism in metabolic syndrome patients
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Adipose tissue; Diet; Endoplasmic reticulum stress; Metabolic syndrome;
   Postprandial state
ID CHAPERONE GENE-EXPRESSION; ER STRESS; OBESITY; LIVER; ACTIVATION;
   APOPTOSIS; CERAMIDE; GLUCOSE; CELLS; MODEL
AB ScopeOur aim was to ascertain whether the quality and quantity of fat in the diet may influence the ER stress at the postprandial state in adipose tissue by analyzing the gene expression of chaperones, folding enzymes, and activators of the UPR.
   Methods and resultsA randomized, controlled trial conducted within the LIPGENE study assigned 39 MetS patients to one of four diets: high-SFA (HSFA; 38% energy (E) from fat, 16% E as SFA), high MUFA (HMUFA; 38% E from fat, 20% E as MUFA), and two low-fat, high-complex carbohydrate (LFHCC; 28% E from fat) diets supplemented with 1.24 g/day of long-chain n-3 PUFA or placebo for 12 wk each. A fat challenge reflecting the same fatty acid composition as the original diets was conducted post intervention. sXBP-1 is induced in the postprandial state irrespective of the diet consumed (p < 0.001). BiP increases postprandially after consumption of diets HMUFA (p = 0.006), LFHCC (p = 0.028), and LFHCCn-3 (p = 0.028). Postprandial mRNA expression levels of CRL, CNX, PDIA3, and GSTP1 in AT did not differ between the different types of diets.
   ConclusionOur results suggest that upregulation of the unfolded protein response at the postprandial state may represent an adaptive mechanism to counteract diet-induced stress.
C1 [Camargo, Antonio; Meneses, Maria E.; Rangel-Zuniga, Oriol A.; Perez-Martinez, Pablo; Marin, Carmen; Delgado-Lista, Javier; Paniagua, Juan A.; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Univ Cordoba, Lipids & Atherosclerosis Unit, Reina Sofia Univ Hosp, IMIBIC, E-14004 Cordoba, Spain.
   [Camargo, Antonio; Meneses, Maria E.; Rangel-Zuniga, Oriol A.; Perez-Martinez, Pablo; Marin, Carmen; Delgado-Lista, Javier; Paniagua, Juan A.; Tinahones, Francisco J.; Malagon, Maria M.; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
   [Tinahones, Francisco J.] Hosp Virgen de la Victoria, Biomed Res Lab, Malaga, Spain.
   [Roche, Helen] Univ Coll Dublin, UCD Inst Food & Hlth, UCD Conway Inst, Sch Publ Hlth & Populat Sci, Dublin, Ireland.
   [Malagon, Maria M.] Univ Cordoba, Dept Cell Biol Physiol & Immunol, E-14004 Cordoba, Spain.
C3 Universidad de Cordoba; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; University College Dublin;
   Universidad de Cordoba
RP Lopez-Miranda, J (corresponding author), Univ Cordoba, Inst Salud Carlos III, Reina Sofia Univ Hosp, Lipids & Atherosclerosis Unit,IMIBIC, Av Menendez Pidal S-N, E-14004 Cordoba, Spain.
EM jlopezmir@uco.es
RI Delgado-Lista, Javier/KAM-7412-2024; Jimenez, Francisco/AAJ-9559-2021;
   Lopez-Miranda, Jose/Y-8306-2019; Marin Hinojosa, Carmen/AFO-1294-2022;
   Tinahones, Francisco/AAB-2882-2020; Camargo Garcia, Antonio/G-9720-2015;
   Perez Martinez, Pablo/AEL-6176-2022; MALAGON, MARIA M/L-5386-2014;
   Meneses, Maria E./Q-2572-2018
OI Camargo Garcia, Antonio/0000-0002-0415-4184; Perez Jimenez,
   Francisco/0000-0001-9808-1280; Lopez-Miranda, Jose/0000-0002-8844-0718;
   Tinahones, Francisco J/0000-0001-6871-4403; Perez Martinez,
   Pablo/0000-0001-7716-8117; , Juan A. Paniagua/0000-0003-2892-980X;
   Delgado Lista, Francisco Javier/0000-0002-2982-2716; Rangel-Zuniga,
   Oriol Alberto/0000-0003-3495-5705; Roche, Helen/0000-0002-0628-3318;
   MALAGON, MARIA M/0000-0002-2419-2727; Meneses, Maria
   E./0000-0002-7689-7024; Perez-Jimenez, Francisco/0000-0001-7499-7681
FU European Union [LIPGENE European Integrated Project] [505944];
   Ministerio de Ciencia e Innovacion [AGL2004-07907, AGL2006-01979,
   AGL2009-12270]; CIBER Fisiopatologia de la Obesidad y Nutricion
   [CB06/03/0047]; Consejeria de Innovacion, Ciencia y Empresa, Junta de
   Andalucia [P06-CTS-01425, CTS-03039, CTS-6606]; Consejeria de Salud,
   Junta de Andalucia [06/128, 07/43, PI-0193]; Fondo Europeo de Desarrollo
   Regional (FEDER); Consejo Nacional de Ciencia y Tecnologia, Mexico
   (CONACYT)
FX The CIBEROBN is an initiative of the Instituto de Salud Carlos III,
   Madrid, Spain. We would like to thank M<SUP>a</SUP> Jose Gomez-Luna for
   her technical support. This work was funded partly by research grants
   from the European Union [LIPGENE European Integrated Project-505944],
   from the Ministerio de Ciencia e Innovacion [grant numbers
   AGL2004-07907, AGL2006-01979, AGL2009-12270 (to J. L.-M.)]; CIBER
   Fisiopatologia de la Obesidad y Nutricion [grant number CB06/03/0047];
   Consejeria de Innovacion, Ciencia y Empresa, Junta de Andalucia [grant
   number P06-CTS-01425 (to J. L.-M.) CTS-03039 and CTS-6606 (to MMM)]; and
   Consejeria de Salud, Junta de Andalucia [grant numbers 06/128, 07/43,
   PI-0193 (to J. L.-M.)]); Fondo Europeo de Desarrollo Regional (FEDER).
   M. E. M. had a fellowship from the Consejo Nacional de Ciencia y
   Tecnologia, Mexico (CONACYT).
CR Aguilar PS, 2006, MOL MICROBIOL, V62, P1507, DOI 10.1111/j.1365-2958.2006.05484.x
   [Anonymous], 1996, Am J Clin Nutr, V64, p524S, DOI 10.1093/ajcn/64.3.524S
   Blüher M, 2010, CURR OPIN LIPIDOL, V21, P38, DOI 10.1097/MOL.0b013e3283346ccc
   Boden G, 2008, DIABETES, V57, P2438, DOI 10.2337/db08-0604
   Boden G, 2011, OBESITY, V19, P1366, DOI 10.1038/oby.2011.71
   Borradaile NM, 2006, J LIPID RES, V47, P2726, DOI 10.1194/jlr.M600299-JLR200
   Caviglia JM, 2011, J LIPID RES, V52, P1636, DOI 10.1194/jlr.M016931
   de Mello VDF, 2008, METABOLISM, V57, P192, DOI 10.1016/j.metabol.2007.08.024
   Dhahbi JM, 2002, J NUTR, V132, P31, DOI 10.1093/jn/132.1.31
   Dhahbi JM, 1997, J NUTR, V127, P1758, DOI 10.1093/jn/127.9.1758
   Eizirik DL, 2008, ENDOCR REV, V29, P42, DOI 10.1210/er.2007-0015
   Galgani JE, 2008, AM J PHYSIOL-ENDOC M, V295, pE1009, DOI 10.1152/ajpendo.90558.2008
   GETHING MJ, 1992, NATURE, V355, P33, DOI 10.1038/355033a0
   Gotoh T, 2011, INT J INFLAMM, V2011, DOI 10.4061/2011/259462
   Grundy SM, 2004, ARTERIOSCL THROM VAS, V24, pE13, DOI 10.1161/01.ATV.0000111245.75752.C6
   Harding HP, 2002, DIABETES, V51, pS455, DOI 10.2337/diabetes.51.2007.S455
   Herman MA, 2012, NATURE, V484, P333, DOI 10.1038/nature10986
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   HWANG C, 1992, SCIENCE, V257, P1496, DOI 10.1126/science.1523409
   Jakobsen CH, 2008, J LIPID RES, V49, P2089, DOI 10.1194/jlr.M700389-JLR200
   Jiao P, 2011, OBESITY, V19, P483, DOI 10.1038/oby.2010.200
   Kahn BB, 2000, J CLIN INVEST, V106, P473, DOI 10.1172/JCI10842
   Khoury D. E., 2009, ATHEROSCLEROSIS, V210, P307
   Lairon D, 2007, EUR J CLIN NUTR, V61, P1145, DOI 10.1038/sj.ejcn.1602749
   Lee AH, 2003, MOL CELL BIOL, V23, P7448, DOI 10.1128/MCB.23.21.7448-7459.2003
   Loureiro J, 2006, ADV IMMUNOL, V92, P225, DOI 10.1016/S0065-2776(06)92006-9
   Medina-Gomez G, 2005, DIABETES, V54, P1706, DOI 10.2337/diabetes.54.6.1706
   Meneses ME, 2011, MOL NUTR FOOD RES, V55, P1759, DOI 10.1002/mnfr.201100200
   Ni M, 2007, FEBS LETT, V581, P3641, DOI 10.1016/j.febslet.2007.04.045
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Pena-Orihuela P., 2013, J NUTR BIOCH, DOI [10.1016/j.jnutbio.2013.02.012, DOI 10.1016/J.JNUTBI0.2013.02.012]
   Perez-Martinez P, 2010, CLIN SCI, V119, P251, DOI 10.1042/CS20100015
   Piersma T, 2003, TRENDS ECOL EVOL, V18, P228, DOI 10.1016/S0169-5347(03)00036-3
   Ruotolo Giacomo, 2002, Curr Cardiol Rep, V4, P494, DOI 10.1007/s11886-002-0113-6
   Sage AT, 2012, OBESITY, V20, P748, DOI 10.1038/oby.2011.144
   Sharma NK, 2008, J CLIN ENDOCR METAB, V93, P4532, DOI 10.1210/jc.2008-1001
   Shaw DI, 2009, BRIT J NUTR, V101, P750, DOI 10.1017/S0007114508039962
   Slawik M, 2007, GENES NUTR, V2, P41, DOI 10.1007/s12263-007-0014-9
   Sun ZW, 2002, SHOCK, V18, P99, DOI 10.1097/00024382-200208000-00001
   Trayhurn P, 2008, BRIT J NUTR, V100, P227, DOI 10.1017/S0007114508971282
   Urano F, 2000, SCIENCE, V287, P664, DOI 10.1126/science.287.5453.664
   Wang D, 2006, ENDOCRINOLOGY, V147, P943, DOI 10.1210/en.2005-0570
   Wei YR, 2006, AM J PHYSIOL-ENDOC M, V291, pE275, DOI 10.1152/ajpendo.00644.2005
   Yubero-Serrano EM, 2012, J GERONTOL A-BIOL, V67, P3, DOI 10.1093/gerona/glr167
   Zhang KZ, 2008, NATURE, V454, P455, DOI 10.1038/nature07203
   Zhang Y, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-122
NR 47
TC 8
Z9 10
U1 0
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD DEC
PY 2013
VL 57
IS 12
BP 2166
EP 2176
DI 10.1002/mnfr.201300036
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 293AZ
UT WOS:000329945100008
PM 23934773
DA 2025-06-11
ER

PT J
AU Mohammadi-Sartang, M
   Babajafari, S
   Kohansal, A
   Rostami, H
   Pourmahmoudi, A
   Sohrabi, Z
AF Mohammadi-Sartang, Mohsen
   Babajafari, Siavash
   Kohansal, Atefeh
   Rostami, Hosein
   Pourmahmoudi, Azizollah
   Sohrabi, Zahra
TI Effects of daily functional acorn cake consumption on insulin resistance
   in individuals with obesity or overweight and the metabolic syndrome: a
   placebo-controlled randomised clinical trial
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Metabolic syndrome; Obesity; Acorn; Oak
ID QUERCUS SPP.; ANTIOXIDANT ACTIVITY; OXIDATIVE STRESS; ADIPONECTIN;
   ASSOCIATION; WEIGHT; ACID; INTERVENTION; INFLAMMATION; SENSITIVITY
AB The metabolic syndrome is a multi-factorial condition and functional foods need more investigation as novel adjunct treatments for this group. This study aimed to determine the effects of daily consumption of a functional acorn cake in conjunction with energy restriction (119.50 kJ) on individuals with overweight or obesity and the metabolic syndrome. In this randomised double-blinded study, eighty-four participants were randomly allocated to either an energy-restricted diet plus two servings (2 x 30 g)/d of functional acorn cake (a cake made of acorn for the intervention group) (FC) (n 42) or an energy-restricted diet plus placebo cake (PC) (n 42). Body composition and biochemical parameters were measured before and after 10 weeks of intervention. Seventy-three participants completed this trial. No differences in loss of body weight, waist circumference, fat mass, fasting blood glucose and blood pressure were shown between two groups. Body weight decreased by 4 center dot 2 (sd 1 center dot 9) kg and 5 center dot 1 (sd 2 center dot 8) kg in PC and FC groups, respectively. Compared with PC, the consumption of FC resulted in a significant reduction in serum insulin (P = 0 center dot 02), homoeostasis model assessment for insulin resistance (P = 0 center dot 02), high-sensitivity C-reactive protein (P = 0 center dot 04) and a significant increase in adiponectin concentration (P = 0 center dot 04). Although lipid metabolism did not differ among groups, total cholesterol and HDL-cholesterol improved non-significantly in the FC group. Functional acorn cake as an adjunct to energy restriction could possibly improve insulin resistance in individuals with obesity. Further research is needed to elucidate whether functional acorn cake can be used as a preventive strategy for the metabolic syndrome in individuals with obesity.
C1 [Mohammadi-Sartang, Mohsen; Babajafari, Siavash; Kohansal, Atefeh; Sohrabi, Zahra] Shiraz Univ Med Sci, Nutr Res Ctr, Shiraz, Iran.
   [Rostami, Hosein] Baqiyatallah Univ Med Sci, Hlth Res Ctr, Life Style Inst, Tehran, Iran.
   [Pourmahmoudi, Azizollah] Yasuj Univ Med Sci, Sch Hlth & Nutr, Dept Nutr, Yasuj, Iran.
C3 Shiraz University of Medical Science; Baqiyatallah University of Medical
   Sciences (BMSU); Yasouj University
RP Rostami, H (corresponding author), Baqiyatallah Univ Med Sci, Hlth Res Ctr, Life Style Inst, Tehran, Iran.
EM hoseinrostami2043@gmail.com
RI Esfandabad, Siavash/A-6807-2019; pourmahmoudi, azizollah/HSA-8811-2023;
   Sohrabi, Zahra/R-4948-2017
FU Nutrition Research Center, Shiraz University of Medical Sciences
FX A special thanks goes to the staff of 'Noono namak' bakery workshop for
   providing the cakes. We also thank Mr Hamid reza Raiesi and Mr Reza
   Barati for their spiritual supports. The present study was supported by
   the Nutrition Research Center, Shiraz University of Medical Sciences. M.
   M., H. R. and S. B. designed the study protocol; M. M., H. R., A. K., Z.
   S. and S. B. contributed to the data collection, data analysis,
   interpretation of results and manuscript drafting; M. M., A. P., H. R.,
   Z. S. and S. B. contributed to the editing and revision of the
   manuscript. All authors read and approved the final version of the
   paper. There are no conflicts of interest.
CR Ahmadi S, 2018, DIABETES, V67, DOI 10.2337/db18-264-LB
   Ahmadi S, 2019, J NUTR BIOCHEM, V67, P1, DOI 10.1016/j.jnutbio.2019.01.011
   Ahmadi Shokouh, 2017, Obes Control Ther, V4, DOI 10.15226/2374-8354/4/2/00140
   Akcan T, 2017, J FOOD SCI TECH MYS, V54, P3050, DOI 10.1007/s13197-017-2740-3
   Bouskila M, 2005, INT J OBESITY, V29, pS17, DOI 10.1038/sj.ijo.0802908
   CUNNIFF P., 1997, J AOAC Intl, V80, p127A
   Delzenne NM, 2011, ANNU REV NUTR, V31, P15, DOI 10.1146/annurev-nutr-072610-145146
   Dogan A, 2015, J ETHNOPHARMACOL, V176, P243, DOI 10.1016/j.jep.2015.10.034
   Domazetovic V, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10020160
   Coello SD, 2008, DIABETES RES CLIN PR, V82, P256, DOI 10.1016/j.diabres.2008.08.001
   Ekramzadeh M, 2013, IRAN J KIDNEY DIS, V7, P304
   Evans JL, 2002, ENDOCR REV, V23, P599, DOI 10.1210/er.2001-0039
   Evans JL, 2005, ANTIOXID REDOX SIGN, V7, P1040, DOI 10.1089/ars.2005.7.1040
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Halford JCG, 2012, P NUTR SOC, V71, P350, DOI 10.1017/S0029665112000134
   Huang HH, 2016, OBES REV, V17, P1329, DOI 10.1111/obr.12458
   Janani C, 2015, DIABETES METAB SYND, V9, P46, DOI 10.1016/j.dsx.2014.09.015
   Juretic N, 2021, NUTRITION, V85, DOI 10.1016/j.nut.2021.111139
   Kang MyungHwa Kang MyungHwa, 2004, Korean Journal of Nutrition, V37, P169
   Kim YA, 2018, NUTR RES REV, V31, P35, DOI [10.1017/S095442241700018X, 10.1007/s13311-017-0536-9]
   Korus A, 2017, EUR FOOD RES TECHNOL, V243, P1429, DOI 10.1007/s00217-017-2853-y
   Kwon DY, 2012, EUR J NUTR, V51, P529, DOI 10.1007/s00394-011-0236-x
   Landrier JF, 2009, ENDOCRINOLOGY, V150, P5318, DOI 10.1210/en.2009-0506
   León-Camacho M, 2004, J AM OIL CHEM SOC, V81, P447, DOI 10.1007/s11746-004-0921-8
   Lihn AS, 2005, OBES REV, V6, P13, DOI 10.1111/j.1467-789X.2005.00159.x
   MacLean W.C., 2003, FOOD EN METH AN CONV
   Mahan LK, 2016, Krauses Food the Nutrition Care Process-E-Book: Krauses Food the Nutrition Care Process-E-Book
   Makihara H, 2016, BIOL PHARM BULL, V39, P1137, DOI 10.1248/bpb.b16-00064
   Mallappa Rashmi H, 2012, Indian J Endocrinol Metab, V16, P20, DOI 10.4103/2230-8210.91178
   Molavi H., 2015, J. FBT, V5, P53
   Moorthi RV, 2006, CLIN CHIM ACTA, V367, P132, DOI 10.1016/j.cca.2005.12.004
   Nakamura A, 2018, J DIABETES INVEST, V9, P1106, DOI 10.1111/jdi.12821
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Papoti VT, 2018, FOOD SCI BIOTECHNOL, V27, P819, DOI 10.1007/s10068-017-0293-x
   Rakic S, 2006, J FOOD ENG, V74, P416, DOI 10.1016/j.jfoodeng.2005.03.057
   S?hretoglu D., 2004, ANK UNIV EGIT BILIM, V33, P183
   Shaheen M, 2017, INT J PHARMACOL, V13, P501, DOI 10.3923/ijp.2017.501.506
   Shen XH, 2010, EXP BIOL MED, V235, P47, DOI 10.1258/ebm.2009.009122
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Tejerina D, 2011, FOOD CHEM, V124, P997, DOI 10.1016/j.foodchem.2010.07.058
   The International Pharmacopoeia, 2003, TESTS GEN REQ DOS FO
   Vinha AF, 2016, COMPR REV FOOD SCI F, V15, P947, DOI 10.1111/1541-4337.12220
   Visser M, 1999, JAMA-J AM MED ASSOC, V282, P2131, DOI 10.1001/jama.282.22.2131
   Wallert M, 2021, MOL NUTR FOOD RES, V65, DOI 10.1002/mnfr.202000097
   Wing RR, 2010, ARCH INTERN MED, V170, P1566, DOI 10.1001/archinternmed.2010.334
   Yang WS, 2001, J CLIN ENDOCR METAB, V86, P3815, DOI 10.1210/jc.86.8.3815
NR 47
TC 1
Z9 2
U1 1
U2 5
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD APR 14
PY 2023
VL 129
IS 7
BP 1142
EP 1150
AR PII S0007114522002288
DI 10.1017/S0007114522002288
EA AUG 2022
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA H5AM0
UT WOS:000840558300001
PM 39655470
DA 2025-06-11
ER

PT J
AU Suvarna, CM
   Raju, RS
   Malothu, N
   Guntupalli, C
AF Suvarna, Ch. Malathi
   Raju, Subhakar R.
   Malothu, Narender
   Guntupalli, Chakravarthi
TI Investigation of Lupinus angustifolius Extracts against
   High-Fructose Diet-Induced Metabolic Syndrome in Male Wistar Rats
SO PHARMACOGNOSY RESEARCH
LA English
DT Article
DE Lupinus angustifolius; Simvastatin; Oxidative stress; Hepatic lipid
   regulation; Hematological parameters
AB Background: Metabolic syndrome is a global health concern, affecting a significant portion of the population worldwide. According to the World Health Organization (WHO), the prevalence of metabolic syndrome is increasing globally due to the rising of obesity and physical inactivity. Objectives: In the present study, we evaluated Lupinus angustifolius seeds for their potential in alleviating metabolic abnormalities associated with metabolic syndrome induced by High Fructose Diet. Materials and Methods: Hexane and ethyl acetate seeds extracts of L. angustifolius (HELA and EAELA) were screened for phytochemical constituents. Normoglycemic male albino Wistar rats were distributed into 6 groups with 6 in each. Fructose solution (10% w/v) administered p.o. for 8 weeks caused induction of Metabolic Disorder. The metabolic parameters were assessed and recorded before and after the administration of 200 mg/kg of extracts over 8 weeks. Results: Preliminary screening demonstrated the presence of flavonoids, alkaloids, glycosides among others from both extracts. HELA and EAELA showed a significant (p<0.001) decrease in obesity. They also led to significantly (p<0.001) decreased expression of inflammatory mediators like IL -6, TGF beta, and TNF-alpha. Hematological parameters exhibited improvement whereas HbA1C expressed a significant (p<0.001) increase in plasma insulin and HOMA IR revealed a significant (p<0.001) decrease in insulin resistance when compared to disease control. Metabolic hormone levels also showed a positive change after administration where leptin and adiponectin levels are decreased (p<0.001 and p<0.1 respectively) and gherlin levels were increased non -significantly (p<0.05). Antihyperlipidemic, antioxidant potential of the extracts was more proficient. Conclusion: The EAELA at 200 mg/kg displayed significant capacity in inhibiting the Metabolic Syndrome induced by High fructose diet when compared to that of HELA at 200 mg/kg which was effective in comparison with Standard.
C1 [Suvarna, Ch. Malathi; Raju, Subhakar R.; Malothu, Narender; Guntupalli, Chakravarthi] Koneru Lakshmaiah Educ Fdn, Dept Pharmacognosy & Phytochem, KL Coll Pharm, Guntur, Andhra Pradesh, India.
C3 Koneru Lakshmaiah Education Foundation (K L Deemed to be University)
RP Guntupalli, C (corresponding author), Koneru Lakshmaiah Educ Fdn, Dept Pharmacognosy & Phytochem, KL Coll Pharm, Guntur, Andhra Pradesh, India.
EM chakravarthi123@kluniversity.in
RI Malothu, Narender/ABF-6269-2020
CR Arya DS, 2010, TOXICOL MECH METHOD, V20, P564, DOI 10.3109/15376516.2010.514962
   Choi HK, 2007, AM J MED, V120, P442, DOI 10.1016/j.amjmed.2006.06.040
   Desco MC, 2002, DIABETES, V51, P1118, DOI 10.2337/diabetes.51.4.1118
   Guguloth SK, 2022, PHARMACOGN RES, V14, P53, DOI 10.5530/pres.14.1.9
   Guguloth Sarvan Kumar, 2021, Research Journal of Pharmacy and Technology, V14, P879, DOI 10.5958/0974-360X.2021.00156.6
   Hidalgo J, 2014, Panminerva Med, V56, P1
   Huang TW, 2015, FOOD NUTR RES, V59, DOI 10.3402/fnr.v59.29018
   Guzmán-Gerónimo RI, 2017, J MED FOOD, V20, P110, DOI [10.1089/jmf.2016.0087, 10.1089/jmf.2016.3851]
   Jamshidi L., 2014, Zahedan Journal of Research in Medical Sciences, V16, P55
   Jeon YD, 2018, J MED FOOD, V21, P244, DOI 10.1089/jmf.2017.3939
   Jung JY, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-18
   Kim B, 2013, NUTR RES, V33, P406, DOI 10.1016/j.nutres.2013.03.001
   Maiese K, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/875961
   Merone L, 2017, DIABETES RES CLIN PR, V127, P238, DOI 10.1016/j.diabres.2017.02.019
   Rodina AV, 2013, PATOL FIZIOL EKSP TE, V2012, P15
   Whitehead JP, 2006, DIABETES OBES METAB, V8, P264, DOI 10.1111/j.1463-1326.2005.00510.x
   Yanpallewar SU, 2003, PHYTOMEDICINE, V10, P391, DOI 10.1078/0944-7113-00230
NR 17
TC 1
Z9 1
U1 0
U2 1
PU PHCOG NET
PI KARNATAKA
PA 17, 2ND FLR, BUDDHA VIHAR RD, NEAR SPORTS ZONE, COX TOWN, BENGALURU,
   KARNATAKA, 560005, INDIA
SN 0974-8490
EI 0976-4836
J9 PHARMACOGN RES
JI Pharmacogn. Res.
PD APR-JUN
PY 2024
VL 16
IS 2
BP 391
EP 400
DI 10.5530/pres.16.2.49
PG 10
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA E3C9E
UT WOS:001301823300021
OA hybrid
DA 2025-06-11
ER

PT J
AU Holder, MK
   Chassaing, B
AF Holder, Mary K.
   Chassaing, Benoit
TI Impact of food additives on the gut-brain axis
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article; Proceedings Paper
CT 25th Annual Meeting of the Society-for-the-Study-of-Ingestive-Behavior
   (SSIB)
CY JUL 18-22, 2017
CL Montreal, CANADA
SP Soc Study Ingest Behavior
DE Emulsifiers; Microbiota; Inflammation; Obesity; Anxiety
ID ANXIETY-LIKE BEHAVIOR; INFLAMMATORY BOWEL DISEASES; LOW-GRADE
   INFLAMMATION; NECROSIS-FACTOR-ALPHA; METABOLIC SYNDROME; MICROBIOTA
   COMPOSITION; INTESTINAL MICROBIOTA; INSULIN-RESISTANCE;
   COLORECTAL-CANCER; CROHNS-DISEASE
AB The mammalian intestinal tract is heavily colonized with a complex community of micro-organisms, present at a very high density, and containing an estimated amount of 10(14) bacteria. The microbiota generally benefits the host, as it plays a central role in maturing the immune system, protecting against infection by entero-pathogens such as Clostridium difficile, and favoring nutrient digestion/energy extraction in our intestine. An altered microbiota, however, can become detrimental and lead to inflammation, metabolic disorders, and even altered behavior/neuroinflammation. While there are many factors involved in regulating the intestinal microbiota composition and the way it interacts with its host, this review will focus on the role played by food additives on host/microbiota relationship.
C1 [Holder, Mary K.; Chassaing, Benoit] Georgia State Univ, Neurosci Inst, Atlanta, GA 30303 USA.
   [Chassaing, Benoit] Georgia State Univ, Inst Biomed Sci, Atlanta, GA 30303 USA.
C3 University System of Georgia; Georgia State University; University
   System of Georgia; Georgia State University
RP Chassaing, B (corresponding author), Georgia State Univ, Inst Biomed Sci, Neurosci Inst, Atlanta, GA 30303 USA.
EM bchassaing@gsu.edu
RI Chassaing, Benoit/R-3819-2017
OI Chassaing, Benoit/0000-0002-4285-769X; Holder, Mary/0000-0003-3585-1094
FU Crohn's and Colitis Foundation; Rainin Foundation; NIH [MH108345]
FX B.C. is a recipient of the Career Development Award from the Crohn's and
   Colitis Foundation and an Innovator Award from the Rainin Foundation.
   M.K.H. is supported by NIH grant MH108345. We thank Samantha Spencer
   (Georgia State University) for manuscript editing and Geert de Vries and
   Andrew T. Gewirtz (Georgia State University) for their precious
   mentoring.
CR Belkaid Y, 2014, CELL, V157, P121, DOI 10.1016/j.cell.2014.03.011
   Bercik P, 2011, NEUROGASTROENT MOTIL, V23, P1132, DOI 10.1111/j.1365-2982.2011.01796.x
   Bercik P, 2010, GASTROENTEROLOGY, V139, P2102, DOI 10.1053/j.gastro.2010.06.063
   Blander JM, 2017, NAT IMMUNOL, V18, P851, DOI 10.1038/ni.3780
   Bravo JA, 2011, P NATL ACAD SCI USA, V108, P16050, DOI 10.1073/pnas.1102999108
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Carvalho FA, 2012, CELL HOST MICROBE, V12, P139, DOI 10.1016/j.chom.2012.07.004
   Chassaing B, 2017, GUT, V66, P1414, DOI 10.1136/gutjnl-2016-313099
   Chassaing B, 2015, NATURE, V519, P92, DOI 10.1038/nature14232
   Chassaing B, 2014, GASTROENTEROLOGY, V147, P1363, DOI 10.1053/j.gastro.2014.08.033
   Chassaing B, 2014, GUT, V63, P1069, DOI 10.1136/gutjnl-2013-304909
   Chassaing B, 2012, ADV IMMUNOL, V116, P93, DOI 10.1016/B978-0-12-394300-2.00003-X
   Chassaing B, 2011, GASTROENTEROLOGY, V140, P1720, DOI 10.1053/j.gastro.2011.01.054
   Conlon MA, 2015, NUTRIENTS, V7, P17, DOI 10.3390/nu7010017
   Cox LM, 2014, CELL, V158, P705, DOI 10.1016/j.cell.2014.05.052
   de La Serre CB, 2015, PHYSIOL BEHAV, V139, P188, DOI 10.1016/j.physbeh.2014.10.032
   Desbonnet L, 2010, NEUROSCIENCE, V170, P1179, DOI 10.1016/j.neuroscience.2010.08.005
   Devkota S, 2013, GUT MICROBES, V4, P172, DOI 10.4161/gmic.23589
   Dewhirst FE, 1999, APPL ENVIRON MICROB, V65, P3287
   Dietrich MO, 2015, CELL, V160, P1222, DOI 10.1016/j.cell.2015.02.024
   Eaden JA, 2001, GUT, V48, P526, DOI 10.1136/gut.48.4.526
   Geirnaert A, 2015, FEMS MICROBIOL ECOL, V91, DOI 10.1093/femsec/fiv054
   Goehler LE, 2008, BRAIN BEHAV IMMUN, V22, P354, DOI 10.1016/j.bbi.2007.08.009
   Hansson GC, 2010, GUT MICROBES, V1, P51, DOI 10.4161/gmic.1.1.10470
   Heijtza RD, 2011, P NATL ACAD SCI USA, V108, P3047, DOI 10.1073/pnas.1010529108
   Holder MK, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0171381
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   HOTAMISLIGIL GS, 1994, P NATL ACAD SCI USA, V91, P4854, DOI 10.1073/pnas.91.11.4854
   Hsiao EY, 2013, CELL, V155, P1451, DOI 10.1016/j.cell.2013.11.024
   Johansson MEV, 2011, P NATL ACAD SCI USA, V108, P4659, DOI 10.1073/pnas.1006451107
   Kim ER, 2014, WORLD J GASTROENTERO, V20, P9872, DOI 10.3748/wjg.v20.i29.9872
   Kokare DM, 2005, BRAIN RES, V1043, P107, DOI 10.1016/j.brainres.2005.02.038
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Liu J, 2007, ENDOCRINOLOGY, V148, P5531, DOI 10.1210/en.2007-0745
   Lloyd-Price J, 2017, NATURE, V550, P61, DOI 10.1038/nature23889
   Lynch SV, 2016, NEW ENGL J MED, V375, P2369, DOI 10.1056/NEJMra1600266
   Lyte M, 1998, PHYSIOL BEHAV, V65, P63, DOI 10.1016/S0031-9384(98)00145-0
   Lyte M, 2006, PHYSIOL BEHAV, V89, P350, DOI 10.1016/j.physbeh.2006.06.019
   Molodecky NA, 2012, GASTROENTEROLOGY, V142, P46, DOI 10.1053/j.gastro.2011.10.001
   Nagao-Kitamoto H, 2016, CELL MOL GASTROENTER, V2, P468, DOI 10.1016/j.jcmgh.2016.02.003
   Neufeld KM, 2011, NEUROGASTROENT MOTIL, V23, DOI 10.1111/j.1365-2982.2010.01620.x
   Ng SC, 2017, LANCET, V390, P2769, DOI 10.1016/S0140-6736(17)32448-0
   Parekh PJ, 2015, CLIN TRANSL GASTROEN, V6, DOI 10.1038/ctg.2015.16
   Peraldi P, 1996, J BIOL CHEM, V271, P13018, DOI 10.1074/jbc.271.22.13018
   Roberts CL, 2013, J CROHNS COLITIS, V7, P338, DOI 10.1016/j.crohns.2013.01.004
   Roberts CL, 2010, GUT, V59, P1331, DOI 10.1136/gut.2009.195370
   Sampson TR, 2016, CELL, V167, P1469, DOI 10.1016/j.cell.2016.11.018
   Suez J, 2014, NATURE, V514, P181, DOI 10.1038/nature13793
   Swidsinski A, 2009, INFLAMM BOWEL DIS, V15, P359, DOI 10.1002/ibd.20763
   Thaler JP, 2012, J CLIN INVEST, V122, P153, DOI 10.1172/JCI59660
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Van den Abbeele P, 2013, ISME J, V7, P949, DOI 10.1038/ismej.2012.158
   Van den Abbeele P, 2012, MICROB BIOTECHNOL, V5, P106, DOI 10.1111/j.1751-7915.2011.00308.x
   Viennois E, 2017, CANCER RES, V77, P27, DOI [10.1158/0008-5472.CAN-16-1359, 10.1158/0008-5472.can-16-1359]
   Vijay-Kumar M, 2010, SCIENCE, V328, P228, DOI 10.1126/science.1179721
   WOSTMANN BS, 1983, LAB ANIM SCI, V33, P46
   Wu GD, 2011, SCIENCE, V334, P105, DOI 10.1126/science.1208344
NR 59
TC 21
Z9 22
U1 0
U2 40
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD AUG 1
PY 2018
VL 192
SI SI
BP 173
EP 176
DI 10.1016/j.physbeh.2018.02.025
PG 4
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S); Conference Proceedings Citation Index - Social Science &amp; Humanities (CPCI-SSH)
SC Psychology; Behavioral Sciences
GA GM5LW
UT WOS:000438179900021
PM 29454065
DA 2025-06-11
ER

PT J
AU Bhatti, JS
   Bhatti, GK
   Reddy, PH
AF Bhatti, Jasvinder Singh
   Bhatti, Gurjit Kaur
   Reddy, P. Hemachandra
TI Mitochondrial dysfunction and oxidative stress in metabolic disorders -
   A step towards mitochondria based therapeutic strategies
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Review
DE Metabolic syndrome; Mitochondria; Oxidative stress; Reactive oxygen
   species; Mitochondria-targeted antioxidants; Cardiovascular disease;
   Pre-diabetes; Type-2-diabetes; Obesity
ID OXYGEN-FREE-RADICALS; EXACERBATES CEREBRAL INFARCTION;
   ALZHEIMERS-DISEASE IMPLICATIONS; SKELETAL-MUSCLE MITOCHONDRIA; ACTIVATED
   PROTEIN-KINASE; TUMOR-NECROSIS-FACTOR; INSULIN-RESISTANCE; TARGETED
   ANTIOXIDANT; NEURODEGENERATIVE DISEASES; CALORIE RESTRICTION
AB Mitochondria are the powerhouses of the cell and are involved in essential functions of the cell, including ATP production, intracellular Ca2+ regulation, reactive oxygen species production & scavenging, regulation of apoptotic cell death and activation of the caspase family of proteases. Mitochondrial dysfunction and oxidative stress are largely involved in aging, cancer, age-related neurodegenerative and metabolic syndrome. In the last decade, tremendous progress has been made in understanding mitochondrial structure, function and their physiology in metabolic syndromes such as diabetes, obesity, stroke and hypertension, and heart disease. Further, progress has also been made in developing therapeutic strategies, including lifestyle interventions (healthy diet and regular exercise), pharmacological strategies and mitochondria-targeted approaches. These strategies were mainly focused to reduce mitochondrial dysfunction and oxidative stress and to maintain mitochondrial quality in metabolic syndromes. The purpose of our article is to highlight the recent progress on the mitochondrial role in metabolic syndromes and also summarize the progress of mitochondria-targeted molecules as therapeutic targets to treat metabolic syndromes. This article is part of a Special Issue entitled: Oxidative Stress and Mitochondrial Quality in Diabetes/Obesity and Critical Illness Spectrum of Diseases- edited by P. Hemachandra Reddy. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Bhatti, Jasvinder Singh] Sri Guru Gobind Singh Coll, Dept Biotechnol & Bioinformat, Sect 26, Chandigarh 160019, India.
   [Bhatti, Jasvinder Singh; Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Garrison Inst Aging, 3601 4th St,MS 9424, Lubbock, TX 79430 USA.
   [Bhatti, Gurjit Kaur] Panjab Univ, UGC Ctr Excellence Nano Applicat, UIPS Bldg, Chandigarh 160014, India.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Cell Biol & Biochem Dept, 3601 4th St,MS 9424, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Neurosci & Pharmacol Dept, 3601 4th St,MS 9424, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Neurol Dept, 3601 4th St,MS 9424, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Speech Dept, 3601 4th St,MS 9424, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Language & Hearing Sci Dept, 3601 4th St,MS 9424, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Garrison Inst Aging, South West Campus,6630 S Quaker Suite E,MS 7495, Lubbock, TX 79413 USA.
C3 Texas Tech University System; Texas Tech University Health Sciences
   Center Lubbock; Panjab University; Texas Tech University System; Texas
   Tech University Health Sciences Center Lubbock; Texas Tech University
   System; Texas Tech University Health Sciences Center Lubbock; Texas Tech
   University System; Texas Tech University Health Sciences Center Lubbock;
   Texas Tech University System; Texas Tech University Health Sciences
   Center Lubbock; Texas Tech University System; Texas Tech University
   Health Sciences Center Lubbock; Texas Tech University System; Texas Tech
   University Health Sciences Center Lubbock
RP Bhatti, JS (corresponding author), Sri Guru Gobind Singh Coll, Dept Biotechnol & Bioinformat, Sect 26, Chandigarh 160019, India.
EM jasvinderbhatti@yahoo.com
RI Bhatti, Jasvinder/AAC-4853-2019; Bhatti, Gurjit/AAU-6478-2020
FU NIH [AG042178, AG047812]; Garrison Family Foundation; University Grants
   Commission, India under Raman Post-Doctoral Research Fellowship in USA
   [5-82/2016 (IC)]
FX Work presented in this article is supported by NIH grants AG042178,
   AG047812 and the Garrison Family Foundation. Dr. Jasvinder Singh Bhatti
   is financially supported by the University Grants Commission, India
   under Raman Post-Doctoral Research Fellowship in USA [F.No. 5-82/2016
   (IC)].
CR Abdul-Ghani MA, 2008, CURR DIABETES REP, V8, P173, DOI 10.1007/s11892-008-0030-1
   Abramov AY, 2007, J NEUROSCI, V27, P1129, DOI 10.1523/JNEUROSCI.4468-06.2007
   Adlam VJ, 2005, FASEB J, V19, P1088, DOI 10.1096/fj.05-3718com
   Albiero M, 2015, METAB SYNDR RELAT D, V13, P161, DOI 10.1089/met.2015.0005
   Anderson RM, 2009, TOXICOL PATHOL, V37, P47, DOI 10.1177/0192623308329476
   Andreyev AI, 2005, BIOCHEMISTRY-MOSCOW+, V70, P200, DOI 10.1007/s10541-005-0102-7
   [Anonymous], 2015, Mol. Neurobiol.
   ANTONETTI DA, 1995, J CLIN INVEST, V95, P1383, DOI 10.1172/JCI117790
   Ashrafian H, 2007, CIRCULATION, V116, P434, DOI 10.1161/CIRCULATIONAHA.107.702795
   Barbieri E, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/917085
   Barja G, 2000, FASEB J, V14, P312, DOI 10.1096/fasebj.14.2.312
   Barja G, 2002, AGEING RES REV, V1, P397, DOI 10.1016/S1568-1637(02)00008-9
   Barnham KJ, 2004, NAT REV DRUG DISCOV, V3, P205, DOI 10.1038/nrd1330
   Beckman KB, 1999, MUTAT RES-FUND MOL M, V424, P51, DOI 10.1016/S0027-5107(99)00007-X
   BELCH JJF, 1991, BRIT HEART J, V65, P245
   Bhatti GK, 2016, J DIABETES COMPLICAT, V30, P72, DOI 10.1016/j.jdiacomp.2015.07.008
   Bhatti J.S., 2007, INT J DIABETES DEV C, V27
   Bindu S., 2016, TRENDS ENDOCRINOL ME
   Blake R, 2014, BBA-GEN SUBJECTS, V1840, P1404, DOI 10.1016/j.bbagen.2013.11.007
   Bloemen PGM, 1996, AM J PHYSIOL-LUNG C, V270, pL80, DOI 10.1152/ajplung.1996.270.1.L80
   Brown GC, 2012, MITOCHONDRION, V12, P1, DOI 10.1016/j.mito.2011.02.001
   Bugger H, 2008, CLIN SCI, V114, P195, DOI 10.1042/CS20070166
   Calkins MJ, 2011, HUM MOL GENET, V20, P4515, DOI 10.1093/hmg/ddr381
   Calò LA, 2015, CLIN ENDOCRINOL, V83, P994, DOI 10.1111/cen.12817
   Cantó C, 2009, CURR OPIN LIPIDOL, V20, P98, DOI 10.1097/MOL.0b013e328328d0a4
   Carvalho E, 2005, AM J PHYSIOL-ENDOC M, V289, pE551, DOI 10.1152/ajpendo.00116.2005
   Cassidy-Stone A, 2008, DEV CELL, V14, P193, DOI 10.1016/j.devcel.2007.11.019
   Chalkiadaki A, 2012, NAT REV ENDOCRINOL, V8, P287, DOI 10.1038/nrendo.2011.225
   Chan PH, 2001, J CEREBR BLOOD F MET, V21, P2, DOI 10.1097/00004647-200101000-00002
   Chen Jiawei, 2004, Indian Heart J, V56, P163
   Chen Le, 2011, Congest Heart Fail, V17, P257
   Chen L, 2014, FERTIL STERIL, V102, P1167, DOI 10.1016/j.fertnstert.2014.06.027
   Chen XJ, 2005, NAT REV GENET, V6, P815, DOI 10.1038/nrg1708
   Chistiakov DA, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/238463
   Cho DH, 2010, CELL MOL LIFE SCI, V67, P3435, DOI 10.1007/s00018-010-0435-2
   Choksi KB, 2004, BBA-MOL BASIS DIS, V1688, P95, DOI 10.1016/j.bbadis.2003.11.007
   Choo HJ, 2006, DIABETOLOGIA, V49, P784, DOI 10.1007/s00125-006-0170-2
   Cipolat S, 2004, P NATL ACAD SCI USA, V101, P15927, DOI 10.1073/pnas.0407043101
   Civitarese AE, 2007, PLOS MED, V4, P485, DOI 10.1371/journal.pmed.0040076
   Cooper SA, 2007, AM J PHYSIOL-HEART C, V293, pH2009, DOI 10.1152/ajpheart.00522.2007
   CORRALDEBRINSKI M, 1992, NAT GENET, V2, P324, DOI 10.1038/ng1292-324
   Dalle-Donne I, 2006, CLIN CHEM, V52, P601, DOI 10.1373/clinchem.2005.061408
   Dallner G, 2000, FREE RADICAL BIO MED, V29, P285, DOI 10.1016/S0891-5849(00)00307-5
   Dare AJ, 2015, REDOX BIOL, V5, P163, DOI 10.1016/j.redox.2015.04.008
   Das P, 2016, Mymensingh Med J, V25, P148
   De Pauw A, 2009, AM J PATHOL, V175, P927, DOI 10.2353/ajpath.2009.081155
   Dhalla NS, 2000, J HYPERTENS, V18, P655, DOI 10.1097/00004872-200018060-00002
   Dhanasekaran A, 2004, J BIOL CHEM, V279, P37575, DOI 10.1074/jbc.M404003200
   Dickinson BC, 2011, NAT CHEM BIOL, V7, P504, DOI [10.1038/nchembio.607, 10.1038/NCHEMBIO.607]
   Ding WX, 2012, BIOL CHEM, V393, P547, DOI 10.1515/hsz-2012-0119
   Doyle KP, 2008, NEUROPHARMACOLOGY, V55, P310, DOI 10.1016/j.neuropharm.2008.01.005
   Dröge W, 2002, PHYSIOL REV, V82, P47, DOI 10.1152/physrev.00018.2001
   Duncan JG, 2007, CIRCULATION, V115, P909, DOI 10.1161/CIRCULATIONAHA.106.662296
   Elgass K, 2013, BBA-MOL CELL RES, V1833, P150, DOI 10.1016/j.bbamcr.2012.05.002
   Elliott PJ, 2008, CURR OPIN INVEST DR, V9, P371
   Feillet-Coudray C, 2014, FREE RADICAL RES, V48, P1232, DOI 10.3109/10715762.2014.945079
   Finkel T, 2000, NATURE, V408, P239, DOI 10.1038/35041687
   Finkel T, 2007, NATURE, V448, P767, DOI 10.1038/nature05985
   Friedman JR, 2014, NATURE, V505, P335, DOI 10.1038/nature12985
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Galley HF, 2010, CRIT CARE, V14, DOI 10.1186/cc9098
   Gastaldi G., 2008, REV MED SUISSE, V4
   Global C., 2014, LANCET DIABETES ENDO, V2, P634
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Guarente L, 2006, NATURE, V444, P868, DOI 10.1038/nature05486
   Hales KG, 2004, MITOCHONDRION, V4, P285, DOI 10.1016/j.mito.2004.05.007
   Hales KG, 1997, CELL, V90, P121, DOI 10.1016/S0092-8674(00)80319-0
   Halliwell B., 2000, FREE RADICAL BIO MED, V3rd
   Halliwell B, 2006, PLANT PHYSIOL, V141, P312, DOI 10.1104/pp.106.077073
   Harper ME, 2004, ACTA PHYSIOL SCAND, V182, P321, DOI 10.1111/j.1365-201X.2004.01370.x
   He Q, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/654198
   Hock MB, 2009, ANNU REV PHYSIOL, V71, P177, DOI 10.1146/annurev.physiol.010908.163119
   Hojlund K, 2008, ENDOCRIN METAB CLIN, V37, P713, DOI 10.1016/j.ecl.2008.06.006
   Holloway GP, 2009, APPL PHYSIOL NUTR ME, V34, P440, DOI 10.1139/H09-028
   Hoppins S, 2014, CURR OPIN CELL BIOL, V29, P46, DOI 10.1016/j.ceb.2014.03.005
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Hu F, 2011, CELL SIGNAL, V23, P1528, DOI 10.1016/j.cellsig.2011.05.008
   Huynh Frank K, 2013, Diabetes Manag (Lond), V3, P245
   Ide T, 2000, CIRC RES, V86, P152, DOI 10.1161/01.RES.86.2.152
   Ide T, 1999, CIRCULATION, V100, P690, DOI 10.1161/01.CIR.100.7.690
   Ide T, 2001, CIRC RES, V88, P529, DOI 10.1161/01.RES.88.5.529
   Ide T, 1999, CIRC RES, V85, P357, DOI 10.1161/01.RES.85.4.357
   Irving Brian A, 2007, Curr Diab Rep, V7, P249, DOI 10.1007/s11892-007-0039-x
   Itoh K, 2013, TRENDS CELL BIOL, V23, P64, DOI 10.1016/j.tcb.2012.10.006
   Jäger S, 2007, P NATL ACAD SCI USA, V104, P12017, DOI 10.1073/pnas.0705070104
   James AM, 2002, J BIOMED SCI, V9, P475, DOI 10.1159/000064721
   Jauslin ML, 2003, FASEB J, V17, P1972, DOI 10.1096/fj.03-0240fje
   Jenner P, 2003, ANN NEUROL, V53, pS26, DOI 10.1002/ana.10483
   Jezek P, 2005, INT J BIOCHEM CELL B, V37, P2478, DOI 10.1016/j.biocel.2005.05.013
   Jheng HF, 2012, MOL CELL BIOL, V32, P309, DOI 10.1128/MCB.05603-11
   Jornayvaz FR, 2010, ESSAYS BIOCHEM, V47, P69, DOI [10.1042/bse0470069, 10.1042/BSE0470069]
   Joseph AM, 2014, MED SPORT SCI, V60, P48, DOI 10.1159/000357335
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Kelley DE, 2002, DIABETES, V51, P2944, DOI 10.2337/diabetes.51.10.2944
   Kelso GF, 2001, J BIOL CHEM, V276, P4588, DOI 10.1074/jbc.M009093200
   KEMNITZ JW, 1994, AM J PHYSIOL, V266, pE540, DOI 10.1152/ajpendo.1994.266.4.E540
   Kim GW, 2002, STROKE, V33, P809, DOI 10.1161/hs0302.103745
   Kim JA, 2008, CIRC RES, V102, P401, DOI 10.1161/CIRCRESAHA.107.165472
   Kitada M, 2013, CURR DRUG TARGETS, V14, P622, DOI 10.2174/1389450111314060002
   Korkmaz GG, 2013, METABOLISM, V62, P828, DOI 10.1016/j.metabol.2013.01.002
   Kostis JB, 2005, AM J HYPERTENS, V18, P731, DOI 10.1016/j.amjhyper.2004.11.038
   Kowaltowski AJ, 2009, FREE RADICAL BIO MED, V47, P333, DOI 10.1016/j.freeradbiomed.2009.05.004
   Krebs M, 2005, DIABETES OBES METAB, V7, P621, DOI 10.1111/j.1463-1326.2004.00439.x
   Kumar S, 2015, ANTIOXID REDOX SIGN, V22, P1060, DOI 10.1089/ars.2014.6213
   Kuzmicic J, 2011, REV ESP CARDIOL, V64, P916, DOI 10.1016/j.recesp.2011.05.018
   Lagouge M, 2006, CELL, V127, P1109, DOI 10.1016/j.cell.2006.11.013
   Leguisamo NM, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-100
   Lin MT, 2006, NATURE, V443, P787, DOI 10.1038/nature05292
   Lo EH, 2003, NAT REV NEUROSCI, V4, P399, DOI 10.1038/nrn1106
   Lowell BB, 2005, SCIENCE, V307, P384, DOI 10.1126/science.1104343
   Lowes DA, 2008, FREE RADICAL BIO MED, V45, P1559, DOI 10.1016/j.freeradbiomed.2008.09.003
   Luque-Contreras D, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/497802
   Maassen J, 2006, DIABETOLOGIA, V49, P619, DOI 10.1007/s00125-006-0165-z
   Maassen JA, 2004, DIABETES, V53, pS103, DOI 10.2337/diabetes.53.2007.S103
   Madamanchi NR, 2007, CIRC RES, V100, P460, DOI 10.1161/01.RES.0000258450.44413.96
   Mailloux RJ, 2016, CURR PHARM DESIGN, V22, P4763, DOI 10.2174/1381612822666160629070914
   Manczak M, 2006, HUM MOL GENET, V15, P1437, DOI 10.1093/hmg/ddl066
   Manczak M, 2011, HUM MOL GENET, V20, P2495, DOI 10.1093/hmg/ddr139
   Mao GW, 2010, J NUTR, V140, P1425, DOI 10.3945/jn.110.121715
   Mao PZ, 2013, BBA-MOL BASIS DIS, V1832, P2322, DOI 10.1016/j.bbadis.2013.09.005
   Meex RCR, 2010, DIABETES, V59, P572, DOI 10.2337/db09-1322
   Mehta K, 2002, NUTR REV, V60, P289, DOI 10.1301/002966402320387224
   Mehta SL, 2007, BRAIN RES REV, V54, P34, DOI 10.1016/j.brainresrev.2006.11.003
   Meigs JB, 2007, DIABETES CARE, V30, P2529, DOI 10.2337/dc07-0817
   Mercer JR, 2012, FREE RADICAL BIO MED, V52, P841, DOI 10.1016/j.freeradbiomed.2011.11.026
   Meuer K, 2007, CELL DEATH DIFFER, V14, P651, DOI 10.1038/sj.cdd.4402087
   Misra A, 2009, METAB SYNDR RELAT D, V7, P497, DOI 10.1089/met.2009.0024
   Mitsuyoshi H, 2008, HEPATOL RES, V38, P348, DOI 10.1111/j.1872-034X.2007.00280.x
   Mogensen M, 2007, DIABETES, V56, P1592, DOI 10.2337/db06-0981
   Mootha VK, 2003, NAT GENET, V34, P267, DOI 10.1038/ng1180
   Morino K, 2005, J CLIN INVEST, V115, P3587, DOI 10.1172/JCI25151
   Morino K, 2012, DIABETES, V61, P877, DOI 10.2337/db11-1391
   Most J., 2016, Ageing Res. Rev
   Mulder H, 2009, MOL CELL ENDOCRINOL, V297, P34, DOI 10.1016/j.mce.2008.05.015
   Murakami K, 1998, J NEUROSCI, V18, P205
   Murphy MP, 2007, ANNU REV PHARMACOL, V47, P629, DOI 10.1146/annurev.pharmtox.47.120505.105110
   Murphy MP, 2009, BIOCHEM J, V417, P1, DOI 10.1042/BJ20081386
   Ni R, 2016, FREE RADICAL BIO MED, V90, P12, DOI 10.1016/j.freeradbiomed.2015.11.013
   Nielsen J, 2010, AM J PHYSIOL-ENDOC M, V298, pE706, DOI 10.1152/ajpendo.00692.2009
   Nisoli E, 2007, CIRC RES, V100, P795, DOI 10.1161/01.RES.0000259591.97107.6c
   Nojiri H, 2006, J BIOL CHEM, V281, P33789, DOI 10.1074/jbc.M602118200
   Ohta Y, 2011, AM J PHYSIOL-HEART C, V300, pH1637, DOI 10.1152/ajpheart.01185.2009
   Omodei D, 2011, FEBS LETT, V585, P1537, DOI 10.1016/j.febslet.2011.03.015
   Ong SB, 2013, ANTIOXID REDOX SIGN, V19, P400, DOI 10.1089/ars.2012.4777
   Otani H, 2011, ANTIOXID REDOX SIGN, V15, P1911, DOI 10.1089/ars.2010.3739
   Ozgen IT, 2012, J PEDIATR ENDOCR MET, V25, P261, DOI 10.1515/jpem-2011-0397
   Pan WH, 2008, ASIA PAC J CLIN NUTR, V17, P37
   Parihar P, 2015, EXP GERONTOL, V61, P130, DOI 10.1016/j.exger.2014.12.004
   Parish R., 2005, CURR DIABETES REP, V5, P177, DOI DOI 10.1007/S11892-005-0006-3
   Park K, 2009, DIABETES CARE, V32, P1302, DOI 10.2337/dc09-0259
   Patti ME, 2003, P NATL ACAD SCI USA, V100, P8466, DOI 10.1073/pnas.1032913100
   Petersen KF, 2003, SCIENCE, V300, P1140, DOI 10.1126/science.1082889
   Phielix E, 2010, DIABETOLOGIA, V53, P1714, DOI 10.1007/s00125-010-1764-2
   Pieczenik SR, 2007, EXP MOL PATHOL, V83, P84, DOI 10.1016/j.yexmp.2006.09.008
   Pirola L, 2004, DIABETOLOGIA, V47, P170, DOI 10.1007/s00125-003-1313-3
   Poitout V, 2001, Journ Annu Diabetol Hotel Dieu, P75
   Pollex RL, 2006, NAT CLIN PRACT CARD, V3, P482, DOI 10.1038/ncpcardio0638
   Powell RD, 2015, J TRAUMA ACUTE CARE, V78, P573, DOI 10.1097/TA.0000000000000533
   Qi X, 2013, J CELL SCI, V126, P789, DOI 10.1242/jcs.114439
   Razak F, 2004, VASC MED, V9, P222, DOI 10.1191/1358863x04vm568xx
   Reaven GM, 1996, CIRCULATION, V93, P1780, DOI 10.1161/01.CIR.93.10.1780
   Reddy, 2009, CNS SPECTRUMS, V14, P16
   Reddy PH, 2006, J BIOMED BIOTECHNOL, DOI 10.1155/JBB/2006/31372
   Reddy PH, 2014, DRUG DISCOV TODAY, V19, P951, DOI 10.1016/j.drudis.2014.03.020
   Reddy PH, 2014, J ALZHEIMERS DIS, V40, P245, DOI 10.3233/JAD-132060
   Reddy PH, 2012, BBA-MOL BASIS DIS, V1822, P639, DOI 10.1016/j.bbadis.2011.10.011
   Reddy PH, 2011, BRAIN RES, V1415, P136, DOI 10.1016/j.brainres.2011.07.052
   Reddy PH, 2011, BRAIN RES REV, V67, P103, DOI 10.1016/j.brainresrev.2010.11.004
   Reddy PH, 2009, CNS SPECTRUMS, V14, P8, DOI 10.1017/S1092852900024901
   Reddy PH, 2008, NEUROMOL MED, V10, P291, DOI 10.1007/s12017-008-8044-z
   Ren J, 2010, J MOL MED, V88, P993, DOI 10.1007/s00109-010-0663-9
   Reznick RM, 2006, J PHYSIOL-LONDON, V574, P33, DOI 10.1113/jphysiol.2006.109512
   Ritov VB, 2005, DIABETES, V54, P8, DOI 10.2337/diabetes.54.1.8
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Rocha M, 2013, CURR PHARM DESIGN, V19, P5730, DOI 10.2174/13816128113199990373
   Rodgers JT, 2005, NATURE, V434, P113, DOI 10.1038/nature03354
   Röckl KSC, 2008, IUBMB LIFE, V60, P145, DOI 10.1002/iub.21
   Roger VL, 2011, CIRCULATION, V123, pE18, DOI 10.1161/CIR.0b013e3182009701
   Rong JX, 2007, DIABETES, V56, P1751, DOI 10.2337/db06-1135
   Roy M, 2015, CURR OPIN CELL BIOL, V33, P111, DOI 10.1016/j.ceb.2015.02.001
   Russell AP, 2014, BBA-GEN SUBJECTS, V1840, P1276, DOI 10.1016/j.bbagen.2013.11.016
   Salim S, 2010, BRAIN RES, V1359, P178, DOI 10.1016/j.brainres.2010.08.093
   Sayre LM, 2001, CURR MED CHEM, V8, P721, DOI 10.2174/0929867013372922
   Schenk S, 2011, J CLIN INVEST, V121, P4281, DOI 10.1172/JCI58554
   Schrauwen-Hinderling VB, 2007, CURR OPIN CLIN NUTR, V10, P698, DOI 10.1097/MCO.0b013e3282f0eca9
   SCHULZEOSTHOFF K, 1992, J BIOL CHEM, V267, P5317
   Schwarz PEH, 2007, HORM METAB RES, V39, P777, DOI 10.1055/s-2007-990312
   Sharma N, 2011, AM J PHYSIOL-ENDOC M, V300, pE966, DOI 10.1152/ajpendo.00659.2010
   Shaw JM, 2002, TRENDS CELL BIOL, V12, P178, DOI 10.1016/S0962-8924(01)02246-2
   Shenouda SM, 2011, CIRCULATION, V124, P444, DOI 10.1161/CIRCULATIONAHA.110.014506
   SHERRATT HSA, 1991, REV NEUROL, V147, P417
   Short KR, 2005, P NATL ACAD SCI USA, V102, P5618, DOI 10.1073/pnas.0501559102
   Silva F.S., 2016, CURR PHARM DES
   Smith RAJ, 1999, EUR J BIOCHEM, V263, P709, DOI 10.1046/j.1432-1327.1999.00543.x
   Smith RAJ, 2003, P NATL ACAD SCI USA, V100, P5407, DOI 10.1073/pnas.0931245100
   Smith SC, 2007, AM J MED, V120, pS3, DOI 10.1016/j.amjmed.2007.01.002
   Song J, 2001, DIABETES CARE, V24, P865, DOI 10.2337/diacare.24.5.865
   Sowers JR, 2004, AM J PHYSIOL-HEART C, V286, pH1597, DOI 10.1152/ajpheart.00026.2004
   Sparks LM, 2005, DIABETES, V54, P1926, DOI 10.2337/diabetes.54.7.1926
   Suematsu N, 2003, CIRCULATION, V107, P1418, DOI 10.1161/01.CIR.0000055318.09997.1F
   Takahara M, 2014, REV ENDOCR METAB DIS, V15, P317, DOI 10.1007/s11154-014-9294-8
   Tanno M, 2012, BASIC RES CARDIOL, V107, DOI 10.1007/s00395-012-0273-5
   Thanan R, 2015, INT J MOL SCI, V16, P193, DOI 10.3390/ijms16010193
   Toledo FGS, 2007, DIABETES, V56, P2142, DOI 10.2337/db07-0141
   Tsutsui H, 2001, CIRCULATION, V104, P134, DOI 10.1161/01.CIR.104.2.134
   Tsutsui H., 2008, CIRC J SA, V72, pA31
   Tsutsui H, 2011, AM J PHYSIOL-HEART C, V301, pH2181, DOI 10.1152/ajpheart.00554.2011
   Turkmen K, 2014, WORLD J DIABETES, V5, P894, DOI 10.4239/wjd.v5.i6.894
   Turner N, 2008, TRENDS ENDOCRIN MET, V19, P324, DOI 10.1016/j.tem.2008.08.001
   Turrens JF, 2003, J PHYSIOL-LONDON, V552, P335, DOI 10.1113/jphysiol.2003.049478
   Twig G, 2008, BBA-BIOENERGETICS, V1777, P1092, DOI 10.1016/j.bbabio.2008.05.001
   Valko M, 2006, CHEM-BIOL INTERACT, V160, P1, DOI 10.1016/j.cbi.2005.12.009
   Ventura-Clapier R, 2008, CARDIOVASC RES, V79, P208, DOI 10.1093/cvr/cvn098
   Victor VM, 2009, CURR MED CHEM, V16, P4654, DOI 10.2174/092986709789878265
   Vijayan M, 2016, J ALZHEIMERS DIS, V54, P427, DOI 10.3233/JAD-160527
   VIRBASIUS JV, 1994, P NATL ACAD SCI USA, V91, P1309, DOI 10.1073/pnas.91.4.1309
   Wai T, 2016, TRENDS ENDOCRIN MET, V27, P105, DOI 10.1016/j.tem.2015.12.001
   Wang HY, 2016, AM J PHYSIOL-REG I, V310, pR449, DOI 10.1152/ajpregu.00449.2015
   Wang HY, 2016, J GERONTOL A-BIOL, V71, P323, DOI 10.1093/gerona/glv142
   WEINDRUCH R, 1986, J NUTR, V116, P641, DOI 10.1093/jn/116.4.641
   Wiederkehr A, 2006, ENDOCRINOLOGY, V147, P2643, DOI 10.1210/en.2006-0057
   Wisloff U, 2005, SCIENCE, V307, P418, DOI 10.1126/science.1108177
   Wlodek D, 2003, J THEOR BIOL, V225, P33, DOI 10.1016/S0022-5193(03)00218-2
   Wu ZD, 1999, CELL, V98, P115, DOI 10.1016/S0092-8674(00)80611-X
   Yi XW, 2006, DIABETES, V55, P2238, DOI 10.2337/db06-0251
   Yin X., 2016, HUM MOL GENET
   Yorek MA, 2003, FREE RADICAL RES, V37, P471, DOI 10.1080/1071576031000083161
   Youle RJ, 2012, SCIENCE, V337, P1062, DOI 10.1126/science.1219855
   Yu JJ, 2009, ANN NY ACAD SCI, V1173, pE10, DOI 10.1111/j.1749-6632.2009.04952.x
   Zainal TA, 2000, FASEB J, V14, P1825, DOI 10.1096/fj.99-0881com
   Zell R, 1997, MOL CELL BIOCHEM, V177, P61, DOI 10.1023/A:1006896832582
   Zhao Y, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/316523
NR 232
TC 932
Z9 945
U1 11
U2 147
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD MAY
PY 2017
VL 1863
IS 5
SI SI
BP 1066
EP 1077
DI 10.1016/j.bbadis.2016.11.010
PG 12
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA EU5BO
UT WOS:000401046800006
OA Green Accepted, Bronze
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Gerhard, T
   Akincigil, A
   Correll, CU
   Foglio, NJ
   Crystal, S
   Olfson, M
AF Gerhard, Tobias
   Akincigil, Ayse
   Correll, Christoph U.
   Foglio, Neil J.
   Crystal, Stephen
   Olfson, Mark
TI National Trends in Second-Generation Antipsychotic Augmentation for
   Nonpsychotic Depression
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID TREATMENT-RESISTANT DEPRESSION; EXTENDED-RELEASE QUETIAPINE;
   STAR-ASTERISK-D; DOUBLE-BLIND; OLANZAPINE/FLUOXETINE COMBINATION;
   ADJUNCTIVE THERAPY; RISPERIDONE AUGMENTATION; CARDIOMETABOLIC RISK;
   INADEQUATE-RESPONSE; DISORDER
AB Objective: This study estimates national trends and patterns in use of second-generation antipsychotics (SGAs) for adjunctive treatment of nonpsychotic adult depression in office-based practice.
   Method: Twelve consecutive years (1999-2010) of the National Ambulatory Medical Care Survey were analyzed to estimate trends and patterns of adjunctive SGA treatment for adult (= 18 years) nonpsychotic depression in office-based visits. Adjunctive SGA use was examined among all office visits in which depression was diagnosed (N = 7,767), excluding visits with diagnoses for alternative SGA indications (schizophrenia, bipolar disorder, pervasive development disorder, psychotic depression, dementia) and those without an active antidepressant prescription.
   Results: From 1999 to 2010, 8.6% of adult depression visits included an SGA. SGA use rates increased from 4.6% in 1999-2000 to 12.5% in 2009-2010, with an adjusted odds ratio (AOR) for time trend of 2.78 (95% CI, 1.84-4.20). The increase in SGA augmentation was broad-based, with no significant differences in time trends between demographic and clinical subgroups. For the most recent survey years (2005-2010), SGA use rates were higher in visits to psychiatrists than to other physicians (AOR = 5.08; 95% CI, 2.96-8.73), visits covered by public than private insurance (AOR = 3.20; 95% CI, 2.25-4.54), visits with diagnosed major depressive disorder than other depressive disorders (AOR = 1.49; 95% CI, 1.08-2.06), and visits with diabetes, hyperlipidemia, or cardiovascular disease (AOR = 2.13; 95% CI, 1.12-4.03) and lower in visits by patients > 65 years than 18-44 years (AOR = 0.51; 95% CI, 0.32-0.82) and visits that included psychotherapy (AOR = 0.68; 95% CI, 0.47-0.96).
   Conclusions: Between 1999 and 2010, SGAs were increasingly accepted in the outpatient treatment of adult nonpsychotic depression. (C) Copyright 2014 Physicians Postgraduate Press, Inc.
C1 [Gerhard, Tobias; Akincigil, Ayse; Crystal, Stephen] Rutgers State Univ, Ctr Hlth Serv Res Pharmacotherapy Chron Dis Manag, Inst Hlth Hlth Care Policy & Aging Res, New Brunswick, NJ 08901 USA.
   [Akincigil, Ayse] Rutgers State Univ, Sch Social Work, New Brunswick, NJ 08901 USA.
   [Gerhard, Tobias; Foglio, Neil J.] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Pharm Practice & Adm, New Brunswick, NJ 08901 USA.
   [Correll, Christoph U.] North Shore Long Isl Jewish Hlth Syst, Psychiat Res, Zucker Hillside Hosp, Glen Oaks, NY USA.
   [Olfson, Mark] Columbia Univ, Coll Phys & Surg, Dept Psychiat, New York, NY USA.
   [Olfson, Mark] New York State Psychiat Inst & Hosp, New York, NY 10032 USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University System; Rutgers University New Brunswick; Rutgers University
   System; Rutgers University New Brunswick; Northwell Health; Columbia
   University; New York State Psychiatry Institute
RP Gerhard, T (corresponding author), Rutgers State Univ, Ernest Mario Sch Pharm, 112 Paterson St, New Brunswick, NJ 08901 USA.
EM tgerhard@rci.rutgers.edu
RI Olfson, Mark/AAA-8547-2021; Correll, Christoph/D-3530-2011
OI Gerhard, Tobias/0000-0002-8598-5771; Akincigil, Ayse/0000-0002-8624-5038
FU Agency for Healthcare Research & Quality-Centers for Education &
   Research on Therapeutics award [U19 HS021112-02]
FX This work was supported by Agency for Healthcare Research &
   Quality-Centers for Education & Research on Therapeutics award U19
   HS021112-02 for the Rutgers Center for Education and Research on Mental
   Health Therapeutics.
CR Ambulatory health care data, QUESTIONNAIRES DATAS
   [Anonymous], 2010, Practiceguidelinefor the treatment of patients with major depressive disorder
   Bauer M, 2009, J CLIN PSYCHIAT, V70, P540, DOI 10.4088/JCP.08m04629
   Berman RM, 2007, J CLIN PSYCHIAT, V68, P843, DOI 10.4088/JCP.v68n0604
   Berman RM, 2009, CNS SPECTRUMS, V14, P197, DOI 10.1017/S1092852900020216
   Brown ADH, 2009, CNS DRUGS, V23, P583, DOI 10.2165/00023210-200923070-00004
   Cascade Elisa F, 2007, Psychiatry (Edgmont), V4, P21
   Correll CU, 2011, TRENDS MOL MED, V17, P97, DOI 10.1016/j.molmed.2010.10.010
   Correll CU, 2009, JAMA-J AM MED ASSOC, V302, P1765, DOI 10.1001/jama.2009.1549
   Correll CU, 2004, AM J PSYCHIAT, V161, P414, DOI 10.1176/appi.ajp.161.3.414
   Corya SA, 2006, DEPRESS ANXIETY, V23, P364, DOI 10.1002/da.20130
   Cuijpers P, 2009, J CLIN PSYCHIAT, V70, P1219, DOI 10.4088/JCP.09r05021
   De Hert M, 2011, BRIT J PSYCHIAT, V199, P99, DOI 10.1192/bjp.bp.110.084665
   Hert M, 2012, NAT REV ENDOCRINOL, V8, P114, DOI 10.1038/nrendo.2011.156
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P138
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   Dirmaier J, 2012, REV RECENT CLIN TRIA, V7, P141, DOI 10.2174/157488712800100233
   Douglas IJ, 2008, BRIT MED J, V337, DOI 10.1136/bmj.a1227
   El-Khalili N, 2010, INT J NEUROPSYCHOPH, V13, P917, DOI 10.1017/S1461145710000015
   FDA Public Health Advisory, DEATHS WITH ANTIPSYC
   Fullerton CA, 2011, ARCH GEN PSYCHIAT, V68, P1218, DOI 10.1001/archgenpsychiatry.2011.146
   Glassman Alexander H, 2007, Dialogues Clin Neurosci, V9, P9
   Hing E, 2003, INQUIRY-J HEALTH CAR, V40, P401, DOI 10.5034/inquiryjrnl_40.4.401
   Hodgkin D, 2007, CLIN THER, V29, P371, DOI 10.1016/j.clinthera.2007.02.011
   Huskamp HA, 2005, INT J LAW PSYCHIAT, V28, P484, DOI 10.1016/j.ijlp.2005.08.004
   Iosifescu DV, 2005, PSYCHOSOM MED, V67, P703, DOI 10.1097/01.psy.0000170338.75346.d0
   Kan C, 2013, DIABETES CARE, V36, P480, DOI 10.2337/dc12-1442
   Keitner GI, 2008, J PSYCHIATR RES, V43, P205, DOI 10.1016/j.jpsychires.2008.05.003
   Khullar A, 2006, AMERICAN PSYCHIATRIC
   Mahmoud RA, 2007, ANN INTERN MED, V147, P593, DOI 10.7326/0003-4819-147-9-200711060-00003
   Marcus RN, 2008, J CLIN PSYCHOPHARM, V28, P156, DOI 10.1097/JCP.0b013e31816774f9
   Mattingly G, 2006, AMERICAN PSYCHIATRIC
   McIntyre A, 2007, DEPRESS ANXIETY, V24, P487, DOI 10.1002/da.20275
   McIntyre Roger S, 2007, Ann Clin Psychiatry, V19, P257, DOI 10.1080/10401230701653377
   McIntyre RS, 2009, CURR DIABETES REP, V9, P51, DOI 10.1007/s11892-009-0010-0
   Mitchell AJ, 2012, PSYCHOL MED, V42, P125, DOI 10.1017/S003329171100105X
   Mohamed S, 2009, J CLIN PSYCHIAT, V70, P906, DOI 10.4088/JCP.08m04450
   Mojtabai R, 2008, ARCH GEN PSYCHIAT, V65, P962, DOI 10.1001/archpsyc.65.8.962
   Mojtabai R, 2010, ARCH GEN PSYCHIAT, V67, P26, DOI 10.1001/archgenpsychiatry.2009.175
   Nelson JC, 2006, AM J PSYCHIAT, V163, P1864, DOI 10.1176/appi.ajp.163.11.1864
   Nelson JC, 2009, AM J PSYCHIAT, V166, P980, DOI 10.1176/appi.ajp.2009.09030312
   Nielsen J, 2010, NEUROPSYCHOPHARMACOL, V35, P1997, DOI 10.1038/npp.2010.78
   Pampallona S, 2004, ARCH GEN PSYCHIAT, V61, P714, DOI 10.1001/archpsyc.61.7.714
   Pan A, 2010, ARCH INTERN MED, V170, P1884, DOI 10.1001/archinternmed.2010.356
   Papakostas GI, 2008, BIOL PSYCHIAT, V63, P699, DOI 10.1016/j.biopsych.2007.08.010
   Pariente A, 2012, ARCH INTERN MED, V172, P648, DOI 10.1001/archinternmed.2012.28
   Philip NS, 2010, EXPERT OPIN PHARMACO, V11, P709, DOI 10.1517/14656561003614781
   Ray WA, 2009, NEW ENGL J MED, V360, P225, DOI 10.1056/NEJMoa0806994
   Reeves H, 2008, J CLIN PSYCHIAT, V69, P1228, DOI 10.4088/JCP.v69n0805
   Rummel-Kluge C, 2012, SCHIZOPHRENIA BULL, V38, P167, DOI 10.1093/schbul/sbq042
   Rush AJ, 2006, AM J PSYCHIAT, V163, P1905, DOI 10.1176/appi.ajp.163.11.1905
   Schneider LS, 2005, JAMA-J AM MED ASSOC, V294, P1934, DOI 10.1001/jama.294.15.1934
   Shear MK, 2000, AM J PSYCHIAT, V157, P581, DOI 10.1176/appi.ajp.157.4.581
   Shelton RC, 2001, AM J PSYCHIAT, V158, P131, DOI 10.1176/appi.ajp.158.1.131
   Shelton RC, 2005, J CLIN PSYCHIAT, V66, P1289, DOI 10.4088/JCP.v66n1012
   Stapelberg NJC, 2011, AUST NZ J PSYCHIAT, V45, P351, DOI 10.3109/00048674.2011.570427
   Thase ME, 2007, J CLIN PSYCHIAT, V68, P224, DOI 10.4088/JCP.v68n0207
   Thase ME, 2011, CAN J PSYCHIAT, V56, P317, DOI 10.1177/070674371105600602
   Wiles N, 2013, LANCET, V381, P375, DOI 10.1016/S0140-6736(12)61552-9
NR 59
TC 33
Z9 36
U1 0
U2 11
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD MAY
PY 2014
VL 75
IS 5
BP 490
EP U206
DI 10.4088/JCP.13m08675
PG 10
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA AI9LZ
UT WOS:000337255400012
PM 24500284
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ge, Q
   Brichard, S
   Yi, X
   Li, QF
AF Ge, Qian
   Brichard, Sonia
   Yi, Xu
   Li, QiFu
TI microRNAs as a New Mechanism Regulating Adipose Tissue Inflammation in
   Obesity and as a Novel Therapeutic Strategy in the Metabolic Syndrome
SO JOURNAL OF IMMUNOLOGY RESEARCH
LA English
DT Review
ID TOLL-LIKE RECEPTORS; INSULIN-RESISTANCE; CELL DEVELOPMENT;
   GENE-EXPRESSION; INNATE IMMUNITY; HYPOXIA; STRESS; MICE; ADIPOGENESIS;
   ENDOTOXEMIA
AB Obesity is associated closely with the metabolic syndrome ( MS). It is well known that obesity-induced chronic inflammation plays a fundamental role in the pathogenesis of MS. White adipose tissue ( AT) is the primary site for the initiation and exacerbation of obesity-associated inflammation. Exploring the mechanisms of white AT inflammation and resetting the immunological balance in white AT could be crucial for the management of MS. Several prominent molecular mechanisms have been proposed to mediate inflammation in white AT, including hypoxia, endoplasmic reticulum stress, lipotoxicity, and metabolic endotoxemia. Recently, a growing body of evidence supports the role of miRNAs as a new important inflammatory mediator by regulating both the adaptive and innate immunity. This review will focus on the implication of miRNAs in white AT inflammation in obesity, and will also highlight the potential of miRNAs as targets for therapeutic intervention in MS as well as the challenges lying in miRNA-targeting therapeutics.
C1 [Ge, Qian; Li, QiFu] Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrinol, Chongqing 400016, Peoples R China.
   [Brichard, Sonia] Univ Louvain, Inst Expt & Clin Res, Endocrinol Diabet & Nutr Unit, Med Sect, B-1200 Brussels, Belgium.
   [Yi, Xu] Third Mil Med Univ, Daping Hosp, Inst Surg Res, Neurol Unit, Chongqing 400042, Peoples R China.
C3 Chongqing Medical University; Universite Catholique Louvain; Army
   Medical University
RP Li, QF (corresponding author), Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrinol, Chongqing 400016, Peoples R China.
EM liqifu@yeah.net
RI LI, QI/IUM-8577-2023; Brichard, Sonia/B-4597-2013
FU National Key Clinical Department Construction Project
FX This work was supported by grants from the National Key Clinical
   Department Construction Project.
CR Alexander R, 2011, EXPERT OPIN THER TAR, V15, P623, DOI 10.1517/14728222.2011.561317
   Arner E, 2012, DIABETES, V61, P1986, DOI 10.2337/db11-1508
   Asirvatham AJ, 2008, MOL IMMUNOL, V45, P1995, DOI 10.1016/j.molimm.2007.10.035
   Asirvatham AJ, 2009, CYTOKINE, V45, P58, DOI 10.1016/j.cyto.2008.11.010
   Bakheet T, 2001, NUCLEIC ACIDS RES, V29, P246, DOI 10.1093/nar/29.1.246
   Bernstein LE, 2006, ARCH INTERN MED, V166, P902, DOI 10.1001/archinte.166.8.902
   Bourlier V, 2008, CIRCULATION, V117, P806, DOI 10.1161/CIRCULATIONAHA.107.724096
   Brown BD, 2006, NAT MED, V12, P585, DOI 10.1038/nm1398
   Calegari VC, 2011, J BIOL CHEM, V286, P12870, DOI 10.1074/jbc.M110.173021
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Chartoumpekis DV, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034872
   Chatzigeorgiou A, 2012, DIABETOLOGIA, V55, P2583, DOI 10.1007/s00125-012-2607-0
   Chen CZ, 2004, SCIENCE, V303, P83, DOI 10.1126/science.1091903
   Chen X, 2008, CELL RES, V18, P997, DOI 10.1038/cr.2008.282
   Chen YQ, 2008, NATURE, V452, P429, DOI 10.1038/nature06757
   Cheng YH, 2010, CLIN SCI, V119, P87, DOI 10.1042/CS20090645
   Chong MMW, 2008, J EXP MED, V205, P2449, DOI [10.1084/jem.20071219090508c, 10.1084/jem.20081219]
   Cobb BS, 2005, J EXP MED, V201, P1367, DOI 10.1084/jem.20050572
   Colin A, 2009, GLIA, V57, P667, DOI 10.1002/glia.20795
   Corsten MF, 2010, CIRC-CARDIOVASC GENE, V3, P499, DOI 10.1161/CIRCGENETICS.110.957415
   Creely SJ, 2007, AM J PHYSIOL-ENDOC M, V292, pE740, DOI 10.1152/ajpendo.00302.2006
   D'Alessandra Y, 2010, EUR HEART J, V31, P2765, DOI 10.1093/eurheartj/ehq167
   Davis JE, 2008, OBESITY, V16, P1248, DOI 10.1038/oby.2008.210
   Dominguez H, 2005, J VASC RES, V42, P517, DOI 10.1159/000088261
   Elmen J, 2008, NATURE, V452, P896, DOI 10.1038/nature06783
   Emilsson V, 2008, NATURE, V452, P423, DOI 10.1038/nature06758
   FAUST IM, 1978, AM J PHYSIOL, V235, pE279, DOI 10.1152/ajpendo.1978.235.3.E279
   Ge Q, 2012, ENDOCRINOLOGY, V153, P5285, DOI 10.1210/en.2012-1623
   Ghoshal S, 2009, J LIPID RES, V50, P90, DOI 10.1194/jlr.M800156-JLR200
   Grimm D, 2006, NATURE, V441, P537, DOI 10.1038/nature04791
   Haynes CM, 2004, MOL CELL, V15, P767, DOI 10.1016/j.molcel.2004.08.025
   Henegar C, 2008, GENOME BIOL, V9, DOI 10.1186/gb-2008-9-1-r14
   Heneghan HM, 2011, J CLIN ENDOCR METAB, V96, pE846, DOI 10.1210/jc.2010-2701
   Heneghan HM, 2010, OBES REV, V11, P354, DOI 10.1111/j.1467-789X.2009.00659.x
   Hosogai N, 2007, DIABETES, V56, P901, DOI 10.2337/db06-0911
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Huang W, 2010, DIABETES, V59, P347, DOI 10.2337/db09-0016
   Hulsmans M, 2011, FASEB J, V25, P2515, DOI 10.1096/fj.11-181149
   Ji X, 2009, CLIN CHEM, V55, P1944, DOI 10.1373/clinchem.2009.125310
   Jiao P, 2008, DIABET METAB SYND OB, V1, P25
   Kabon B, 2004, ANESTHESIOLOGY, V100, P274, DOI 10.1097/00000542-200402000-00015
   Kang YM, 2009, CARDIOVASC RES, V82, P503, DOI 10.1093/cvr/cvp073
   Klöting N, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004699
   Kopp A, 2009, OBESITY, V17, P648, DOI 10.1038/oby.2008.607
   Krützfeldt J, 2005, NATURE, V438, P685, DOI 10.1038/nature04303
   Lewis BP, 2005, CELL, V120, P15, DOI 10.1016/j.cell.2004.12.035
   Li QJ, 2007, CELL, V129, P147, DOI 10.1016/j.cell.2007.03.008
   Liu LP, 2006, MOL CELL, V21, P521, DOI 10.1016/j.molcel.2006.01.010
   Lu LF, 2009, IMMUNOLOGY, V127, P291, DOI 10.1111/j.1365-2567.2009.03092.x
   Lumeng CN, 2011, J CLIN INVEST, V121, P2111, DOI 10.1172/JCI57132
   Maury E, 2007, AM J PHYSIOL-ENDOC M, V293, pE656, DOI 10.1152/ajpendo.00127.2007
   Maury E, 2010, MOL CELL ENDOCRINOL, V314, P1, DOI 10.1016/j.mce.2009.07.031
   McDermott AM, 2011, PHARM RES-DORDR, V28, P3016, DOI 10.1007/s11095-011-0550-2
   Monte SV, 2012, SURGERY, V151, P587, DOI 10.1016/j.surg.2011.09.038
   Muccioli GG, 2010, MOL SYST BIOL, V6, DOI 10.1038/msb.2010.46
   Müller G, 2011, CELL SIGNAL, V23, P1207, DOI 10.1016/j.cellsig.2011.03.013
   O'Carroll D, 2007, GENE DEV, V21, P1999, DOI 10.1101/gad.1565607
   O'Neill LA, 2011, NAT REV IMMUNOL, V11, P163, DOI 10.1038/nri2957
   Ogawa R, 2010, BIOCHEM BIOPH RES CO, V398, P723, DOI 10.1016/j.bbrc.2010.07.008
   Ortega FJ, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009022
   Parra P, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013005
   Poggi M, 2009, DIABETOLOGIA, V52, P1152, DOI 10.1007/s00125-009-1267-1
   Prieur X, 2010, BBA-MOL CELL BIOL L, V1801, P327, DOI 10.1016/j.bbalip.2009.09.017
   Purkayastha S, 2011, P NATL ACAD SCI USA, V108, P2939, DOI 10.1073/pnas.1006875108
   Sayed D, 2011, PHYSIOL REV, V91, P827, DOI 10.1152/physrev.00006.2010
   Schäffler A, 2007, TRENDS IMMUNOL, V28, P393, DOI 10.1016/j.it.2007.07.003
   Schaeffler A, 2009, IMMUNOLOGY, V126, P233, DOI 10.1111/j.1365-2567.2008.02892.x
   Schaffäler A, 2010, TRENDS IMMUNOL, V31, P228, DOI 10.1016/j.it.2010.03.001
   Sibley CR, 2010, MOL THER, V18, P466, DOI 10.1038/mt.2009.306
   Spalding KL, 2008, NATURE, V453, P783, DOI 10.1038/nature06902
   Strum JC, 2009, MOL ENDOCRINOL, V23, P1876, DOI 10.1210/me.2009-0117
   Suganami T, 2007, BIOCHEM BIOPH RES CO, V354, P45, DOI 10.1016/j.bbrc.2006.12.190
   Thaler JP, 2012, J CLIN INVEST, V122, P153, DOI 10.1172/JCI59660
   Trujillo ME, 2006, ENDOCR REV, V27, P798, DOI 10.1210/er.2006-0033
   Tseng YH, 2010, NAT REV DRUG DISCOV, V9, P465, DOI 10.1038/nrd3138
   Tu BP, 2004, J CELL BIOL, V164, P341, DOI 10.1083/jcb.200311055
   Varma V, 2009, AM J PHYSIOL-ENDOC M, V296, pE1300, DOI 10.1152/ajpendo.90885.2008
   Virtanen KA, 2002, J CLIN ENDOCR METAB, V87, P3902, DOI 10.1210/jc.87.8.3902
   Vitseva OI, 2008, OBESITY, V16, P932, DOI 10.1038/oby.2008.25
   Wang B, 2007, PFLUG ARCH EUR J PHY, V455, P479, DOI 10.1007/s00424-007-0301-8
   Weiler J, 2006, GENE THER, V13, P496, DOI 10.1038/sj.gt.3302654
   Xiao CC, 2008, NAT IMMUNOL, V9, P405, DOI 10.1038/ni1575
   Xie HM, 2009, DIABETES, V58, P1050, DOI 10.2337/db08-1299
   Ye JP, 2007, AM J PHYSIOL-ENDOC M, V293, pE1118, DOI 10.1152/ajpendo.00435.2007
   Yin J, 2009, AM J PHYSIOL-ENDOC M, V296, pE333, DOI 10.1152/ajpendo.90760.2008
   Yun Z, 2002, DEV CELL, V2, P331, DOI 10.1016/S1534-5807(02)00131-4
   Zampetaki A, 2010, CIRC RES, V107, P810, DOI 10.1161/CIRCRESAHA.110.226357
   Zhang KZ, 2008, NATURE, V454, P455, DOI 10.1038/nature07203
   Zhou BY, 2007, P NATL ACAD SCI USA, V104, P7080, DOI 10.1073/pnas.0702409104
   Zhuang GQ, 2012, CIRCULATION, V125, P2892, DOI 10.1161/CIRCULATIONAHA.111.087817
NR 92
TC 69
Z9 76
U1 1
U2 16
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-8861
EI 2314-7156
J9 J IMMUNOL RES
JI J Immunol. Res.
PY 2014
VL 2014
AR 987285
DI 10.1155/2014/987285
PG 10
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA AE2XK
UT WOS:000333836400001
PM 24741638
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Roberts, CK
   Won, D
   Pruthi, S
   Kurtovic, S
   Sindhu, RK
   Vaziri, ND
   Barnard, RJ
AF Roberts, CK
   Won, D
   Pruthi, S
   Kurtovic, S
   Sindhu, RK
   Vaziri, ND
   Barnard, RJ
TI Effect of a short-term diet and exercise intervention on oxidative
   stress, inflammation, MMP-9, and monocyte chemotactic activity in men
   with metabolic syndrome factors
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE atherosclerosis; lipids; cell adhesion molecules; nitric oxide; matrix
   metalloproteinase-9
ID C-REACTIVE PROTEIN; LOW-DENSITY-LIPOPROTEIN; LOW-FAT DIET; LIFE-STYLE
   MODIFICATION; WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; ENDOTHELIAL FUNCTION;
   ADHESION MOLECULES; INSULIN-RESISTANCE; P-SELECTIN
AB The present study was designed to examine the effects of lifestyle modification on key contributing factors to atherogenesis, including oxidative stress, inflammation, chemotaxis, and cell adhesion. Obese men (n = 31), 15 of whom had metabolic syndrome, were placed on a high-fiber, low-fat diet in a 3-wk residential program where food was provided ad libitum and daily aerobic exercise was performed. In each subject, pre- and postintervention fasting blood was drawn for circulating levels of serum lipids, glucose and insulin ( for estimation of insulin sensitivity), oxidative stress-generating enzyme myeloperoxidase and marker 8-isoprostaglandin F-2 alpha, the inflammatory protein C-reactive protein, soluble ICAM-1 as an indicator of endothelial activation, sP-selectin as a marker of platelet activation, the chemokine macrophage inflammatory protein-1 alpha, and total matrix metalloproteinase-9. Using subject sera and human aortic endothelial cell culture systems, we measured VCAM-1 cell surface abundance and monocyte chemotactic protein-1, nitric oxide, superoxide, and hydrogen peroxide production in vitro by fluorometric detection. Also determined in vitro was serum-induced, monocyte adhesion and monocyte chemotactic activity. After 3 wk, significant reductions (P < 0.05) in body mass index, all serum lipids and lipid ratios, fasting glucose, insulin, homeostasis model assessment for insulin resistance, myeloperoxidase, 8-isoprostaglandin F-2 alpha, C-reactive protein, soluble ICAM-1, soluble P-selectin, macrophage inflammatory protein-1 alpha, and matrix metalloproteinase-9 were noted. In vitro, serum-stimulated cellular VCAM-1 expression, monocyte chemotactic protein-1 production, and fluorometric detection of superoxide and hydrogen peroxide production decreased, whereas a concomitant increase in NO production was noted (all P < 0.01). Additionally, both monocyte adhesion (P < 0.05) and MCA (P < 0.01) decreased. Nine of 15 were no longer positive for metabolic syndrome postintervention. Intensive lifestyle modification may ameliorate novel coronary artery disease risk factors in men with metabolic syndrome factors before reversal of obesity. atherosclerosis; lipids; cell adhesion molecules; nitric oxide; matrix metalloproteinase-9.
C1 Univ Calif Los Angeles, Dept Physiol Sci, Los Angeles, CA 90095 USA.
   Charles R Drew Univ Med & Sci, Div Endocrinol Metab & Mol Med, Los Angeles, CA USA.
   Univ Calif Irvine, Dept Med, Div Nephrol & Hypertens, Irvine, CA USA.
C3 University of California System; University of California Los Angeles;
   Charles R. Drew University of Medicine & Science; University of
   California System; University of California Irvine
RP Univ Calif Los Angeles, Dept Physiol Sci, 4101 Life Sci Bldg 621 Charles E Young Dr S, Los Angeles, CA 90095 USA.
EM croberts@ucla.edu
FU NHLBI NIH HHS [F32 HL-68406-01] Funding Source: Medline
CR Abe Y, 1996, J LEUKOCYTE BIOL, V60, P692, DOI 10.1002/jlb.60.6.692
   [Anonymous], 1980, 7 COUNTRIES MULTIVAR
   Baldus S, 2004, FREE RADICAL BIO MED, V37, P902, DOI 10.1016/j.freeradbiomed.2004.06.003
   BARNARD RJ, 1991, ARCH INTERN MED, V151, P1389, DOI 10.1001/archinte.151.7.1389
   BASS DA, 1983, J IMMUNOL, V130, P1910
   BERLINER JA, 1995, CIRCULATION, V91, P2488, DOI 10.1161/01.CIR.91.9.2488
   Blair SN, 1999, MED SCI SPORT EXER, V31, pS646, DOI 10.1097/00005768-199911001-00025
   Brennan M, 2003, NEW ENGL J MED, V349, P1595, DOI 10.1056/NEJMoa035003
   Brennan ML, 2002, J BIOL CHEM, V277, P17415, DOI 10.1074/jbc.M112400200
   CASTELLI WP, 1986, JAMA-J AM MED ASSOC, V256, P2835, DOI 10.1001/jama.256.20.2835
   Chen JW, 2003, ARTERIOSCL THROM VAS, V23, P1559, DOI 10.1161/01.ATV.0000089012.73180.63
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   CZERNIN J, 1995, CIRCULATION, V92, P197, DOI 10.1161/01.CIR.92.2.197
   DAUGHERTY A, 1994, J CLIN INVEST, V94, P437, DOI 10.1172/JCI117342
   Devaraj S, 2005, ARTERIOSCL THROM VAS, V25, P1359, DOI 10.1161/01.ATV.0000168573.10844.ae
   Devaraj S, 2003, CIRCULATION, V107, P398, DOI 10.1161/01.CIR.0000052617.91920.FD
   Eiserich JP, 1998, NATURE, V391, P393, DOI 10.1038/34923
   Ferroni P, 2003, J INVEST MED, V51, P295, DOI 10.1136/jim-51-05-17
   FOGELMAN AM, 1988, J LIPID RES, V29, P1243
   Ford ES, 2002, EPIDEMIOLOGY, V13, P561, DOI 10.1097/00001648-200209000-00012
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Fu XY, 2001, J BIOL CHEM, V276, P41279, DOI 10.1074/jbc.M106958200
   Hambrecht R, 2000, NEW ENGL J MED, V342, P454, DOI 10.1056/NEJM200002173420702
   Hamdy O, 2003, DIABETES CARE, V26, P2119, DOI 10.2337/diacare.26.7.2119
   Heilbronn LK, 2001, ARTERIOSCL THROM VAS, V21, P968, DOI 10.1161/01.ATV.21.6.968
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   KENDALL A, 1991, AM J CLIN NUTR, V53, P1124, DOI 10.1093/ajcn/53.5.1124
   Knowler WC, 2002, NEW ENGL J MED, V346, P393, DOI 10.1056/nejmoa012512
   Koh KK, 2002, ARTERIOSCL THROM VAS, V22, pE19, DOI 10.1161/01.ATV.0000030997.02059.BB
   LAAKSO M, 1993, AM J EPIDEMIOL, V137, P959, DOI 10.1093/oxfordjournals.aje.a116768
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Libby P, 2002, CIRCULATION, V105, P1135, DOI 10.1161/hc0902.104353
   LICHTENSTEIN AH, 1994, ARTERIOSCLER THROMB, V14, P1751, DOI 10.1161/01.ATV.14.11.1751
   Liu SM, 2002, AM J CLIN NUTR, V75, P492, DOI 10.1093/ajcn/75.3.492
   Merten A, 2004, Z KARDIOL, V93, P855, DOI 10.1007/s00392-004-0146-5
   Nakatsubo N, 1998, FEBS LETT, V427, P263, DOI 10.1016/S0014-5793(98)00440-2
   Navab M, 2000, J LIPID RES, V41, P1481
   Navab M, 2002, CURR OPIN LIPIDOL, V13, P363, DOI 10.1097/00041433-200208000-00003
   NAVAB M, 1991, J CLIN INVEST, V88, P2039, DOI 10.1172/JCI115532
   Ockene IS, 2001, CLIN CHEM, V47, P444
   Patrono C, 1997, ARTERIOSCL THROM VAS, V17, P2309, DOI 10.1161/01.ATV.17.11.2309
   Podrez EA, 2000, J CLIN INVEST, V105, P1095, DOI 10.1172/JCI8574
   Rasmussen LM, 2002, SCAND J CLIN LAB INV, V62, P485
   Reape TJ, 1999, ATHEROSCLEROSIS, V147, P213, DOI 10.1016/S0021-9150(99)00346-9
   Renko J, 2004, SCAND J CLIN LAB INV, V64, P255, DOI 10.1080/00365510410006054
   Ridker PM, 2001, CIRCULATION, V103, P491, DOI 10.1161/01.CIR.103.4.491
   Ridker PM, 2000, NEW ENGL J MED, V342, P836, DOI 10.1056/NEJM200003233421202
   Roberts CK, 2002, CIRCULATION, V106, P2530, DOI 10.1161/01.CIR.0000040584.91836.0D
   Roberts CK, 2005, J APPL PHYSIOL, V98, P3, DOI 10.1152/japplphysiol.00852.2004
   ROYALL JA, 1993, ARCH BIOCHEM BIOPHYS, V302, P348, DOI 10.1006/abbi.1993.1222
   VandenHoek TL, 1997, J MOL CELL CARDIOL, V29, P2571, DOI 10.1006/jmcc.1997.0497
   VanLenten BJ, 1995, J CLIN INVEST, V96, P2758, DOI 10.1172/JCI118345
   Wegge JK, 2004, METABOLISM, V53, P377, DOI 10.1016/j.metabol.2003.10.016
   Xu XP, 1999, CIRCULATION, V99, P993, DOI 10.1161/01.CIR.99.8.993
   Yudkin JS, 1999, ARTERIOSCL THROM VAS, V19, P972, DOI 10.1161/01.ATV.19.4.972
   Ziccardi P, 2002, CIRCULATION, V105, P804, DOI 10.1161/hc0702.104279
NR 57
TC 172
Z9 196
U1 1
U2 15
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
EI 1522-1601
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD MAY
PY 2006
VL 100
IS 5
BP 1657
EP 1665
DI 10.1152/japplphysiol.01292.2005
PG 9
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA 040DE
UT WOS:000237358400033
PM 16357066
DA 2025-06-11
ER

PT J
AU Puchkova-Sistac, A
   de Lauzon-Guillain, B
   Girerd, N
   Boivin, JM
   Bozec, E
   Merckle, L
   Nazare, JA
   Laville, M
   Rossignol, P
   Wagner, S
AF Puchkova-Sistac, Anfisa
   de Lauzon-Guillain, Blandine
   Girerd, Nicolas
   Boivin, Jean-Marc
   Bozec, Erwan
   Merckle, Ludovic
   Nazare, Julie-Anne
   Laville, Martine
   Rossignol, Patrick
   Wagner, Sandra
TI Association between eating behaviour and 13-year cardiovascular damages
   in the initially healthy STANISLAS cohort
SO EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
LA English
DT Article
DE Eating behaviour; Cardiovascular damage; Metabolic syndrome; Mediation
   analysis
ID LEFT-VENTRICULAR MASS; OBESITY; RISK; STIFFNESS; STRESS; DESIGN; STYLE;
   INTERVENTIONS; RECRUITMENT; DISEASE
AB Aims Several dimensions of eating behaviour (EB), such as restrained eating (RE), appear to be cross-sectionally associated with certain cardiovascular (CV) diseases and metabolic risk factors although little is known regarding longitudinal associations. This study aimed to assess the associations between EB and CV damage or metabolic syndrome after 13 years, in initially healthy individuals.
   Methods and results This study included 1109 participants from the familial STANISLAS (Suivi Temporaire Annuel Non-Invasif de la Sante des Lorrains Assures Sociaux) cohort study. Emotional eating (EmE), RE, and external eating were assessed using the Dutch Eating Behaviour Questionnaire. Metabolic syndrome and CV damages such as carotid-femoral pulse-wave velocity (cfPWV), left ventricular mass, carotid intima-media thickness, and diastolic dysfunction (DD) were measured after a period of 13 years. Mixed model analysis with a family random effect and adjustment for age, sex, education, temporal gap, physical activity, metabolic factors at baseline, and the onset of CV disease during follow-up, and mediation analysis were performed in adults and adolescents separately. Among adults, EmE was associated with a 38% increased risk of DD 13 years later [odds ratio = 1.38 (1.05; 1.83)]. Stress level mediated 31.9% of this association (P = 0.01). Emotional eating was positively associated with cfPWV (beta=0.02 [0.01; 0.04]). External eating was slightly associated with lower cfPWV (beta=-0.03 [-0.05; -0.01]). No associations were observed between EB dimensions and metabolic syndrome. Energy intake was not found to be a mediator of any associations.
   Conclusion Our results suggest that CV prevention should also take into account EB and include emotion regulation skills teaching.
   Lay Summary The association of three dimensions of eating behaviour [emotional eating, restrained eating, and external eating] with 13 years later cardiovascular damages have been investigated in the initially healthy STANISLAS (Suivi Temporaire Annuel Non-Invasif de la Sante des Lorrains Assures Sociaux) cohort. Emotional eating was associated with higher pulse-wave velocity and an increased risk of diastolic dysfunction. External eating was associated with lower pulse-wave velocity. Stress level was found to be a mediator of the association found between emotional eating and diastolic dysfunction.
   [GRAPHICS]
   .
C1 [Puchkova-Sistac, Anfisa; Girerd, Nicolas; Boivin, Jean-Marc; Bozec, Erwan; Merckle, Ludovic; Rossignol, Patrick; Wagner, Sandra] Univ Lorraine, INI CRCT, FCRIN, INSERM CIC 1433,Nancy CHRU,Inserm U1116, 4 rue Morvan, F-54500 Vandoeuvre Les Nancy, France.
   [de Lauzon-Guillain, Blandine] Univ Paris Cite, Hop Hotel Dieu, CRESS, INRAE,INSERM, 1 Pl PARVIS NOTREDAME, F-75004 Paris, France.
   [Boivin, Jean-Marc] Univ Lorraine, Dept Gen Med, 9 Ave Foret Haye, F-54500 Vandoeuvre Les Nancy, France.
   [Nazare, Julie-Anne; Laville, Martine] Univ Lyon, Univ Claude Bernard Lyon 1, Hospices Civils Lyon,CarMeN Lab,INSERM,INRA,INSA, Ctr Rech Nutr Humaine Rhone Alpes,F CRIN FORCE Ne, 165 chemin Grand Revoyet, Pierre Benite, France.
C3 CHU de Nancy; Universite de Lorraine; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Universite Paris Cite; INRAE;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Hotel-Dieu - APHP; Universite de Lorraine; CHU Lyon; Institut National
   de la Sante et de la Recherche Medicale (Inserm); Universite Claude
   Bernard Lyon 1; INRAE
RP Girerd, N (corresponding author), Univ Lorraine, INI CRCT, FCRIN, INSERM CIC 1433,Nancy CHRU,Inserm U1116, 4 rue Morvan, F-54500 Vandoeuvre Les Nancy, France.
EM n.girerd@chru-nancy.fr
RI Wagner, Sandra/AAD-4918-2022; GIRERD, Nicolas/D-5493-2011; de
   Lauzon-Guillain, Blandine/P-4659-2016
OI Wagner, Sandra/0000-0002-3251-3754; de Lauzon-Guillain,
   Blandine/0000-0001-5887-8842; Puchkova, Anfisa/0000-0003-0174-4768;
   Girerd, Nicolas/0000-0002-3278-2057; Lab, Carmen/0000-0002-5935-3236
FU Centre Hospitalier Regional Universitaire de Nancy (CHRU); French
   Ministry of Solidarity and Health (Programme Hospitalier de Recherche
   Clinique Inter-regional); Contrat de Plan Etat-Lorraine; 'Fonds Europeen
   de Developpement Regional' (FEDER Lorraine); French National Research
   Agency (ANR) as part of the second 'Investissements d'Avenir' programme
   FIGHT-HF [ANR-15-RHU-0004]; French 'Projet investissement d'avenir
   '(PIA) project 'Lorraine Universite d'Excellence' [ANR-15-IDEX-04-LUE];
   European Union-Framework Program (EU-FP) Network of Excellence Ingenious
   HyperCare [LSHM-CT-2006-037093]; EU-FP MEDIA [261409,
   ANR-15-CE14-0032-01, 602904, ANR-16-ECVD-0002-02]; Agence Nationale de
   la Recherche (ANR) [ANR-16-ECVD-0002] Funding Source: Agence Nationale
   de la Recherche (ANR)
FX The 4th examination of the STANISLAS study was sponsored by the Centre
   Hospitalier Regional Universitaire de Nancy (CHRU) and supported by the
   French Ministry of Solidarity and Health (Programme Hospitalier de
   Recherche Clinique Inter-regional 2013), and by the Contrat de Plan
   Etat-Lorraine and the 'Fonds Europeen de Developpement Regional' (FEDER
   Lorraine), and by a public grant overseen by the French National
   Research Agency (ANR) as part of the second 'Investissements d'Avenir'
   programme FIGHT-HF (reference: ANR-15-RHU-0004) and by the French
   'Projet investissement d'avenir '(PIA) project 'Lorraine Universite
   d'Excellence' (reference ANR-15-IDEX-04-LUE). The STANISLAS study is
   also supported by the 6th European Union-Framework Program (EU-FP)
   Network of Excellence Ingenious HyperCare (#LSHM-CT-2006-037093), the
   s7th EU-FP MEDIA (Europeen 'Cooperation'-Theme
   'Health'/FP7-HEALTH-2010-single-stage #261409), HOMAGE (Heart 'Omics' in
   Ageing, 7th Framework Program grant #305507), FOCUS-MR (reference:
   ANR-15-CE14-0032-01), and FIBRO-TARGETS (FP7#602904) projects, and by
   ERA-CVD EXPERT (reference: ANR-16-ECVD-0002-02).
CR Adriaanse MA, 2011, PSYCHOL HEALTH, V26, P23, DOI 10.1080/08870440903207627
   Bozec E, 2020, ARTERY RES, V26, P5, DOI 10.2991/artres.k.200314.001
   Brosch T, 2013, SWISS MED WKLY, V143, DOI 10.4414/smw.2013.13786
   BRUCH H, 1975, AUST NZ J PSYCHIAT, V9, P159, DOI 10.3109/00048677509159842
   Cuspidi C, 2009, J HYPERTENS, V27, P2465, DOI 10.1097/HJH.0b013e32833105a6
   Dar Tawseef, 2019, Curr Treat Options Cardiovasc Med, V21, P23, DOI 10.1007/s11936-019-0724-5
   DESIMONE G, 1995, J AM COLL CARDIOL, V25, P1056, DOI 10.1016/0735-1097(94)00540-7
   Dinu M, 2018, EUR J CLIN NUTR, V72, P30, DOI 10.1038/ejcn.2017.58
   Ferreira JP, 2018, INT J EPIDEMIOL, V47, P395, DOI 10.1093/ije/dyx240
   Ferreira JP, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.116.003529
   Frikha Z, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0122336
   Gerlach G, 2015, OBES REV, V16, P32, DOI 10.1111/obr.12235
   Go AS, 2013, CIRCULATION, V127, P143, DOI [10.1161/CIR.0b013e318282ab8f, 10.1161/CIR.0000000000000366]
   Godet A, 2022, REV ENDOCR METAB DIS, V23, P807, DOI 10.1007/s11154-021-09700-x
   Hainer V, 2006, INT J OBESITY, V30, P830, DOI 10.1038/sj.ijo.0803202
   Herman C P, 1975, J Abnorm Psychol, V84, P66
   Herrmann-Lingen C, 2021, EUR J PREV CARDIOL, V28, P631, DOI 10.1177/2047487319898022
   Holman EA, 2008, ARCH GEN PSYCHIAT, V65, P73, DOI 10.1001/archgenpsychiatry.2007.6
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   KAPLAN HI, 1957, J NERV MENT DIS, V125, P181, DOI 10.1097/00005053-195704000-00004
   Khanji MY, 2018, INT J CARDIOL, V263, P142, DOI 10.1016/j.ijcard.2018.02.094
   Koenders PG, 2011, J OCCUP ENVIRON MED, V53, P1287, DOI 10.1097/JOM.0b013e31823078a2
   Lluch A, 2000, INT J OBESITY, V24, P1493, DOI 10.1038/sj.ijo.0801425
   Lluch A, 1996, EUR PSYCHIAT, V11, P198, DOI 10.1016/0924-9338(96)88391-X
   Lopez-Cepero A, 2018, J ACAD NUTR DIET, V118, P849, DOI 10.1016/j.jand.2017.06.007
   MacKinnon D P, 2000, Prev Sci, V1, P173, DOI 10.1023/A:1026595011371
   Madlala SS, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2020-044904
   Malik VS, 2020, NAT REV ENDOCRINOL, V16, P615, DOI 10.1038/s41574-020-00411-y
   Maniero C, 2023, EUR J PREV CARDIOL, V30, P17, DOI 10.1093/eurjpc/zwac163
   Mason TB, 2019, ASSESSMENT, V26, P907, DOI 10.1177/1073191117719508
   de Chazal HM, 2018, J AM COLL CARDIOL, V72, P1955, DOI 10.1016/j.jacc.2018.07.072
   Nagueh SF, 2009, EUR J ECHOCARDIOGR, V10, P165, DOI [10.1093/ejechocard/jep007, 10.1016/j.echo.2008.11.023]
   Nilsson PM, 2006, J INTERN MED, V260, P134, DOI 10.1111/j.1365-2796.2006.01671.x
   O'Reilly GA, 2014, OBES REV, V15, P453, DOI 10.1111/obr.12156
   Péneau S, 2013, AM J CLIN NUTR, V97, P1307, DOI 10.3945/ajcn.112.054916
   Reichenberger J, 2020, P NUTR SOC, V79, P290, DOI 10.1017/S0029665120007004
   Schacter S., 2021, OBESE HUMANS RATS, P194
   Siest G, 1998, CLIN CHEM LAB MED, V36, P35, DOI 10.1515/CCLM.1998.007
   Sîrbu E, 2015, WIEN KLIN WOCHENSCHR, V127, P555, DOI 10.1007/s00508-015-0799-2
   Snoek HM, 2013, APPETITE, V67, P81, DOI 10.1016/j.appet.2013.03.014
   Song YM, 2020, EAT WEIGHT DISORD-ST, V25, P545, DOI 10.1007/s40519-019-00640-9
   Splansky GL, 2007, AM J EPIDEMIOL, V165, P1328, DOI 10.1093/aje/kwm021
   Steptoe A, 2012, NAT REV CARDIOL, V9, P360, DOI 10.1038/nrcardio.2012.45
   Torres SJ, 2007, NUTRITION, V23, P887, DOI 10.1016/j.nut.2007.08.008
   Townsend N, 2022, NAT REV CARDIOL, V19, P133, DOI 10.1038/s41569-021-00607-3
   Vainik U, 2013, NEUROSCI BIOBEHAV R, V37, P279, DOI 10.1016/j.neubiorev.2012.11.008
   Van Bortel LM, 2012, J HYPERTENS, V30, P445, DOI 10.1097/HJH.0b013e32834fa8b0
   VANSTRIEN T, 1986, INT J EAT DISORDER, V5, P295, DOI 10.1002/1098-108X(198602)5:2<295::AID-EAT2260050209>3.0.CO;2-T
NR 48
TC 4
Z9 4
U1 1
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2047-4873
EI 2047-4881
J9 EUR J PREV CARDIOL
JI Eur. J. Prev. Cardiol.
PD MAR 1
PY 2023
VL 30
IS 4
SI SI
BP 349
EP 357
DI 10.1093/eurjpc/zwac287
EA JAN 2023
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 9M9DG
UT WOS:000911402800001
PM 36626936
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Panahi, Y
   Hosseini, MS
   Khalili, N
   Naimi, E
   Soflaei, SS
   Majeed, M
   Sahebkar, A
AF Panahi, Yunes
   Hosseini, Mahboobeh Sadat
   Khalili, Nahid
   Naimi, Effat
   Soflaei, Sara Saffar
   Majeed, Muhammed
   Sahebkar, Amirhossein
TI Effects of supplementation with curcumin on serum adipokine
   concentrations: A randomized controlled trial
SO NUTRITION
LA English
DT Article
DE Curcumin; Metabolic syndrome; Leptin; Adiponectin; Meta-analysis
ID PLACEBO-CONTROLLED TRIAL; QUALITY-OF-LIFE; CHRONIC PULMONARY
   COMPLICATIONS; SYSTEMIC OXIDATIVE STRESS; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; DOUBLE-BLIND; SULFUR MUSTARD; PIPERINE COMBINATION;
   OBESE INDIVIDUALS
AB Objective: Previous experimental studies have suggested curcumin as a safe phytochemical that can improve insulin resistance through effects on adiponectin and leptin. This study aimed to investigate the effect of curcumin on circulating adiponectin and leptin concentrations in patients with metabolic syndrome.
   Methods: In this pilot, randomized, double-blind, placebo-controlled trial, subjects who met the criteria of metabolic syndrome according to the National Cholesterol Education Program Adult Treatment Panel III criteria were randomly assigned to curcumin (n = 59; 1000 mg/d) or a placebo (n = 58) for 8 wk. Serum adiponectin and leptin concentrations were determined before and after intervention. The pooled effect size for the impact of curcumin supplementation on serum adiponectin and leptin levels was also estimated using random-effects metaanalysis.
   Results: Eight-week supplementation with curcumin was associated with a significant increase in serum adiponectin levels (P < 0.001) and a reduction in serum leptin concentrations (P < 0.001). Serum leptin:adiponectin ratio was also improved by curcumin (P < 0.001). These beneficial effects of curcumin remained significant after adjustment for changes in serum lipids and glucose concentrations and baseline differences in body mass index and serum levels of glucose and glycated hemoglobin as potential confounders of treatment response. Metaanalysis suggested that curcumin supplementation can increase adiponectin levels by 76.78% (95% CI: 6.14-147.42; P = 0.0330), and reduce leptin by 26.49% (95% CI: 70.44 to 17.46), however this latter effect size did not reach statistical significance (P = 0.238).
   Conclusions: Curcumin can improve serum levels of adiponectin and leptin in patients with metabolic syndrome. This trial was registered at the UMIN Clinical Trials Registry (http://www.umin.ac.jp/ctri) under Trial No. UMIN000018339. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Panahi, Yunes] Baqiyatallah Univ Med Sci, Chem Injuries Res Ctr, Tehran, Iran.
   [Hosseini, Mahboobeh Sadat; Khalili, Nahid; Naimi, Effat] Baqiyatallah Univ Med Sci, Dept Endocrinol, Tehran, Iran.
   [Soflaei, Sara Saffar] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Dept Modern Sci & Technol, Mashhad, Iran.
   [Majeed, Muhammed] Sabinsa Inc, Princeton, NJ USA.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Univ Western Australia, Royal Perth Hosp, Sch Med & Pharmacol, Metab Res Ctr, Perth, WA, Australia.
C3 Baqiyatallah University of Medical Sciences (BMSU); Baqiyatallah
   University of Medical Sciences (BMSU); Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; East Metropolitan
   Health Service; Royal Perth Hospital; University of Western Australia
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran.; Sahebkar, A (corresponding author), Univ Western Australia, Royal Perth Hosp, Sch Med & Pharmacol, Metab Res Ctr, Perth, WA, Australia.
EM Sahebkara@mums.ac.ir
RI naeimi, effat/U-3221-2019; Sahebkar, Amirhossein/B-5124-2018; Khalili,
   Nahid/U-1226-2019; Soflaei, Sara/AAI-1461-2019; Hosseini,
   Mahboobeh/U-9514-2018
OI Panahi, Yunes/0000-0002-2504-8356; Saffar Soflaei,
   Sara/0000-0001-6795-0623; hosseini, mahboobeh sadat/0000-0001-8863-1269;
   naeimi, effat/0000-0001-9513-3700
FU Clinical Trial Research Center (Tehran, Iran); Iran National Science
   Foundation [93015237]
FX This study was financially supported by Clinical Trial Research Center
   (Tehran, Iran) and Iran National Science Foundation (grant number:
   93015237). The authors gratefully acknowledge Sami Labs Ltd. (Bangalore,
   India) for providing the drug material used in this trial.
CR Aggarwal BB, 2009, TRENDS PHARMACOL SCI, V30, P85, DOI 10.1016/j.tips.2008.11.002
   Alwi Idrus, 2008, Acta Med Indones, V40, P201
   [Anonymous], J CARDIOVASC PHARM
   Asgary S, 2014, PHYTOTHER RES, V28, P193, DOI 10.1002/ptr.4977
   ATAL CK, 1985, J PHARMACOL EXP THER, V232, P258
   Azimi-Nezhad M, 2012, METAB SYNDR RELAT D, V10, P181, DOI 10.1089/met.2011.0097
   Baum L, 2007, PHARMACOL RES, V56, P509, DOI 10.1016/j.phrs.2007.09.013
   Borenstein M., 2005, COMPREHENSIVE META A
   Boscá AR, 2000, MECH AGEING DEV, V114, P207, DOI 10.1016/S0047-6374(00)00089-0
   Castro AVB, 2014, ARQ BRAS ENDOCRINOL, V58, P600, DOI 10.1590/0004-2730000003223
   Chuengsamarn S, 2014, J NUTR BIOCHEM, V25, P144, DOI 10.1016/j.jnutbio.2013.09.013
   Chuengsamarn S, 2012, DIABETES CARE, V35, P2121, DOI 10.2337/dc12-0116
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Considine RV, 1996, NEW ENGL J MED, V334, P292, DOI 10.1056/NEJM199602013340503
   Ejaz A, 2009, J NUTR, V139, P919, DOI 10.3945/jn.108.100966
   Esfahani M, 2015, IRAN J BASIC MED SCI, V18, P430
   Esmaily H, 2015, CHIN J INTEGR MED, V21, P332, DOI 10.1007/s11655-015-2160-z
   Finucane FM, 2009, DIABETOLOGIA, V52, P2345, DOI 10.1007/s00125-009-1508-3
   Grundy SM, 2016, TRENDS CARDIOVAS MED, V26, P364, DOI 10.1016/j.tcm.2015.10.004
   Hutley L, 2005, AM J MED SCI, V330, P280, DOI 10.1097/00000441-200512000-00005
   Jang EM, 2008, METABOLISM, V57, P1576, DOI 10.1016/j.metabol.2008.06.014
   Kappelle PJWH, 2012, EUR J INTERN MED, V23, P755, DOI 10.1016/j.ejim.2012.06.013
   Kubota M, 2012, NUTR CANCER, V64, P72, DOI 10.1080/01635581.2012.630554
   Kuroda M, 2005, BIOL PHARM BULL, V28, P937, DOI 10.1248/bpb.28.937
   Lau DCW, 2005, AM J PHYSIOL-HEART C, V288, pH2031, DOI 10.1152/ajpheart.01058.2004
   Lee HS, 2007, ASIA PAC J CLIN NUTR, V16, P10
   Liu ML, 2010, BIOCHEM J, V425, P41, DOI 10.1042/BJ20091045
   Lopresti AL, 2015, EUR NEUROPSYCHOPHARM, V25, P38, DOI 10.1016/j.euroneuro.2014.11.015
   Matsuzawa Y, 2004, ARTERIOSCL THROM VAS, V24, P29, DOI 10.1161/01.ATV.0000099786.99623.EF
   Mohammadi A, 2013, PHYTOTHER RES, V27, P374, DOI 10.1002/ptr.4715
   Na LX, 2011, NUTR METAB CARDIOVAS, V21, P526, DOI 10.1016/j.numecd.2009.11.009
   Na LX, 2013, MOL NUTR FOOD RES, V57, P1569, DOI 10.1002/mnfr.201200131
   Nakmareong S, 2011, N-S ARCH PHARMACOL, V383, P519, DOI 10.1007/s00210-011-0624-z
   Norata GD, 2007, STROKE, V38, P2844, DOI 10.1161/STROKEAHA.107.485540
   Panahi Y, 2015, DRUG RES, V65, P567, DOI 10.1055/s-0034-1389986
   Panahi Y, 2015, CLIN NUTR, V34, P1101, DOI 10.1016/j.clnu.2014.12.019
   Panahi Yunes, 2016, Journal of Dietary Supplements, V13, P209, DOI 10.3109/19390211.2015.1008611
   Panahi Yunes, 2016, Journal of Dietary Supplements, V13, P93, DOI 10.3109/19390211.2014.952865
   Panahi Y, 2015, PHYTOTHER RES, V29, P17, DOI 10.1002/ptr.5211
   Panahi Y, 2014, COMPLEMENT THER MED, V22, P851, DOI 10.1016/j.ctim.2014.07.006
   Panahi Y, 2014, PHYTOTHER RES, V28, P1625, DOI 10.1002/ptr.5174
   Panahi Y, 2014, PHYTOTHER RES, V28, P1461, DOI 10.1002/ptr.5149
   Panahi Y, 2012, ANN CLIN BIOCHEM, V49, P580, DOI 10.1258/acb.2012.012040
   Panahi Y, 2012, BRIT J NUTR, V108, P1272, DOI 10.1017/S0007114511006544
   Pari L, 2007, PLANT FOOD HUM NUTR, V62, P25, DOI 10.1007/s11130-006-0037-1
   Ramírez-Boscá A, 2000, MECH AGEING DEV, V119, P41, DOI 10.1016/S0047-6374(00)00169-X
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Sahebkar A., 2015, NAT PROD RES, V29, P1
   Sahebkar A, 2014, PHYTOTHER RES, V28, P633, DOI 10.1002/ptr.5045
   Sahebkar A, 2014, NAT REV CARDIOL, V11, P123, DOI 10.1038/nrcardio.2013.140-c1
   Sahebkar A, 2013, PHYTOTHER RES, V27, P1883, DOI 10.1002/ptr.4952
   Sahebkar A, 2013, BIOFACTORS, V39, P197, DOI 10.1002/biof.1062
   Sahebkar A, 2010, FERTIL STERIL, V94, pE75, DOI 10.1016/j.fertnstert.2010.07.1071
   Satoh N, 2004, DIABETES CARE, V27, P2488, DOI 10.2337/diacare.27.10.2488
   Seo KI, 2008, MOL NUTR FOOD RES, V52, P995, DOI 10.1002/mnfr.200700184
   Shao WJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0028784
   Shehzad A, 2011, EUR J NUTR, V50, P151, DOI 10.1007/s00394-011-0188-1
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Soni K. B., 1992, Indian Journal of Physiology and Pharmacology, V36, P273
   Tang YC, 2009, ENDOCRINOLOGY, V150, P3011, DOI 10.1210/en.2008-1601
   Vettor R, 2005, ALIMENT PHARM THER, V22, P3, DOI 10.1111/j.1365-2036.2005.02587.x
   Wallace AM, 2001, CIRCULATION, V104, P3052, DOI 10.1161/hc5001.101061
   Weisberg SP, 2008, ENDOCRINOLOGY, V149, P3549, DOI 10.1210/en.2008-0262
   Xydakis AM, 2004, J CLIN ENDOCR METAB, V89, P2697, DOI 10.1210/jc.2003-031826
   Zaletel J, 2010, J ENDOCRINOL INVEST, V33, P514, DOI [10.1007/BF03346639, 10.3275/6811]
NR 65
TC 74
Z9 77
U1 1
U2 22
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD OCT
PY 2016
VL 32
IS 10
BP 1116
EP 1122
DI 10.1016/j.nut.2016.03.018
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DU7YE
UT WOS:000382429700012
PM 27297718
OA Bronze
DA 2025-06-11
ER

PT J
AU Chielle, EO
   Trott, A
   Rosa, BD
   Casarin, JN
   Fortuna, PC
   da Cruz, BM
   Moretto, MB
   Moresco, RN
AF Chielle, E. O.
   Trott, A.
   Rosa, B. da Silva
   Casarin, J. N.
   Fortuna, P. C.
   da Cruz, B. M.
   Moretto, M. B.
   Moresco, R. N.
TI Impact of the Ile<SUP>105</SUP>Val Polymorphism of the Glutathione
   S-transferase P1 (GSTP1) Gene on Obesity and Markers of Cardiometabolic
   Risk in Young Adult Population
SO EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
LA English
DT Article
DE obesity; glutathione; polymorphism; biomarkers; cardiometabolic
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; DIABETES-MELLITUS; GSTM1; GSTT1;
   CANCER; CELLS; METAANALYSIS; MECHANISMS; HUMANS
AB aim of the study was to investigate the association between Glutathione S-transferase P1 (GSTP1) gene polymorphism with obesity and markers of cardiometabolic risk. A cross-sectional study was carried out in individuals aged >= 18 and <= 30 years. The study included 54 normal weight, 27 overweight and 68 obese volunteers. Anthropometric measurements and biochemical parameters were evaluated, the DNA was extracted from blood samples and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure GSTP1 Ile(105)Val gene polymorphism of the study participants. Also, biochemical analysis and hormone assays were carried out. A positive association between GSTP1 polymorphism and obesity was observed on subjects carrying at least one G allele (AG and GG). GG genotype was found only in the obese group. The G allele carriers presented 2.4 times higher chance of obesity when compared to those with the AA genotype. These results were independent of sex and age. We suggest that despite a study in population regional (south of Brazil), the GSTP1 gene polymorphism may play a significant role in the increase of susceptibility of obesity and contribute to identify the cardiovascular risk in young adults.
C1 [Chielle, E. O.; Moretto, M. B.; Moresco, R. N.] Univ Fed Santa Maria, Ctr Hlth Sci, Santa Maria, RS, Brazil.
   [da Cruz, B. M.] Univ Fed Santa Maria, Ctr Nat & Exact Sci, Santa Maria, RS, Brazil.
   [Chielle, E. O.; Trott, A.; Rosa, B. da Silva; Casarin, J. N.; Fortuna, P. C.] Univ Western Santa Catarina, UNOESC, Mol Biol Lab, Sao Miguel Do Oeste, SC, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal de
   Santa Maria (UFSM); Universidade do Oeste de Santa Catarina
RP Chielle, EO (corresponding author), Univ Fed Santa Maria, Ctr Hlth Sci, Santa Maria, RS, Brazil.; Chielle, EO (corresponding author), Univ Western Santa Catarina, UNOESC, Mol Biol Lab, Sao Miguel Do Oeste, SC, Brazil.
EM eduardochielle@yahoo.com
RI Moresco, Rafael/K-6118-2017; da Cruz; Manica da Cruz, Ivana/G-4329-2012
OI Moresco, Rafael/0000-0003-3072-5080; da Cruz; Manica da Cruz,
   Ivana/0000-0003-3008-6899
CR Al-Rawi NH, 2011, DIABETES VASC DIS RE, V8, P22, DOI 10.1177/1479164110390243
   [Anonymous], 2000, Obesity: preventing and managing the global epidemic: report of a WHO consultation, P253
   BOYNE AF, 1972, ANAL BIOCHEM, V46, P639, DOI 10.1016/0003-2697(72)90335-1
   Cotton SC, 2000, AM J EPIDEMIOL, V151, P7, DOI 10.1093/oxfordjournals.aje.a010124
   De Lima MFA, 2013, BMC MED GENET, V14, P60
   Montano MAE, 2012, CYTOKINE, V60, P30, DOI 10.1016/j.cyto.2012.05.022
   Gaspar P, 2004, GENET MOL BIOL, V27, P133, DOI 10.1590/S1415-47572004000200001
   Girón MD, 1999, CHEMOSPHERE, V38, P3003, DOI 10.1016/S0045-6535(98)00502-5
   Gottlieb MGV, 2005, GENET MOL RES, V4, P691
   Hayes JD, 1995, CRIT REV BIOCHEM MOL, V30, P445, DOI 10.3109/10409239509083491
   Higdon JV, 2003, ARTERIOSCL THROM VAS, V23, P365, DOI 10.1161/01.ATV.0000063608.43095.E2
   Kahn BB, 2000, J CLIN INVEST, V106, P473, DOI 10.1172/JCI10842
   Karalis KP, 2009, FEBS J, V276, P5747, DOI 10.1111/j.1742-4658.2009.07304.x
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   Kim JS, 2006, J KOREAN MED SCI, V21, P1, DOI 10.3346/jkms.2006.21.1.1
   Lapenna D, 2001, FREE RADICAL BIO MED, V31, P331, DOI 10.1016/S0891-5849(01)00584-6
   Mahmoud AA, 2012, ARCH MED SCI, V4, P631
   MEDRANO JF, 1990, BIOTECHNIQUES, V8, P43
   MILLER SA, 1988, NUCLEIC ACIDS RES, V16, P1215, DOI 10.1093/nar/16.3.1215
   Mo ZN, 2009, PROSTATE, V69, P662, DOI 10.1002/pros.20907
   Mohn A, 2005, J CLIN ENDOCR METAB, V90, P2653, DOI 10.1210/jc.2004-2178
   Moussa SA., 2008, Romanian J.Biophys, V18, P225
   Nomani H, 2011, MOL CELL BIOCHEM, V354, P181, DOI 10.1007/s11010-011-0817-2
   Piva SJ, 2011, CLIN BIOCHEM, V44, P345, DOI 10.1016/j.clinbiochem.2010.12.001
   Ramprasath T, 2011, BIOCHEM BIOPH RES CO, V407, P49, DOI 10.1016/j.bbrc.2011.02.097
   Rotter V, 2003, J BIOL CHEM, V278, P45777, DOI 10.1074/jbc.M301977200
   Sorrentino SA, 2010, CIRCULATION, V121, P110, DOI 10.1161/CIRCULATIONAHA.108.836346
   Tang ZH, 2014, ASIAN PAC J CANCER P, V15, P2075, DOI 10.7314/APJCP.2014.15.5.2075
   Vincent HK, 2007, DIABETES OBES METAB, V9, P813, DOI 10.1111/j.1463-1326.2007.00692.x
   Vincent HK, 2006, INT J OBESITY, V30, P400, DOI 10.1038/sj.ijo.0803177
   Wang GY, 2006, BIOCHEM BIOPH RES CO, V341, P310, DOI 10.1016/j.bbrc.2005.12.195
   Weiner J.S., 1981, PRACTICAL HUMAN BIOL, P439
   Yalin S, 2007, CELL BIOCHEM FUNCT, V25, P509, DOI 10.1002/cbf.1339
NR 33
TC 11
Z9 11
U1 0
U2 2
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0947-7349
EI 1439-3646
J9 EXP CLIN ENDOCR DIAB
JI Exp. Clin. Endocrinol. Diabet.
PD MAY
PY 2017
VL 125
IS 5
BP 335
EP 341
DI 10.1055/s-0042-105279
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FA7NR
UT WOS:000405633900010
PM 28561194
DA 2025-06-11
ER

PT J
AU da Silva, IV
   Santos, AC
   Matos, A
   da Silva, AP
   Soveral, G
   Rebelo, I
   Bicho, M
AF da Silva, Ines Vieira
   Santos, Ana Carolina
   Matos, Andreia
   da Silva, Alda Pereira
   Soveral, Graca
   Rebelo, Irene
   Bicho, Manuel
TI Association of Aquaporin-3, Aquaporin-7, NOS3 and CYBA polymorphisms
   with hypertensive disorders in women
SO PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR
   HEALTH
LA English
DT Article
DE Aquaporins; Polymorphisms; Oxidative Stress; Preeclampsia; Hypertension;
   Metabolic Syndrome
ID HYDROGEN-PEROXIDE; OXIDATIVE STRESS; CARDIOVASCULAR RISK; GENE;
   EXPRESSION; CHANNEL; PREECLAMPSIA; BLOOD; AQP9
AB Preeclampsia (PE), a pregnancy disorder influenced by oxidative stress and hypoxia, affects the health of the mother and baby and is associated with an increased risk of future hypertension (HT). Aquaporins are a family of water channels, comprising members that also transport glycerol (aquaglyceroporins) and hydrogen peroxide (peroxiporins), key molecules for metabolic homeostasis and redox signaling. Here, we investigated the association of Aquaporin-3 (AQP3; rs2231231), Aquaporin-7 (AQP7; rs2989924), NOS3 (4B/A intron) and CYBA (rs4673) genetic polymorphisms with the development of hypertensive disorders by qPCR/PCR in a cohort of 150 normotensive (NT) women (N = 90) or with previous PE (N = 60) during pregnancy. Prospectively, women were reclassified 2-16 years after pregnancy as NT (N = 98) or hypertensive (N = 48) and the genetic associations were reevaluated. In addition, genetic associations were reevaluated and compared between normotensive and hypertensive (HT) subjects. We found that AQP3 rs2231231, an aquaglyceroporin/peroxiporin, is associated with the development of HT, whereas AQP7, NOS3 and CYBA polymorphism did not correlate with PE or future HT. Because AQP3 was associated with hypertension only after pregnancy, its role might be related to later risk factors of hypertension such as metabolic syndrome or oxidative stress.
C1 [da Silva, Ines Vieira; Soveral, Graca] Univ Lisbon, Fac Farm, Res Inst Med iMedULisboa, Lisbon, Portugal.
   [da Silva, Ines Vieira; Soveral, Graca] Univ Lisbon, Fac Farm, Dept Ciencias Farmaceut & Med, Ave Prof Gama Pinto, P-1649003 Lisbon, Portugal.
   [Santos, Ana Carolina; Matos, Andreia; da Silva, Alda Pereira; Bicho, Manuel] Univ Lisbon, Fac Med, Inst Saude Ambiental, Lab Genet, P-1649026 Lisbon, Portugal.
   [Santos, Ana Carolina; Matos, Andreia; Bicho, Manuel] Inst Invest Cient Bento Rocha Cabral, Calcada Bento Da Rocha Cabral 14, P-1250012 Lisbon, Portugal.
   [Matos, Andreia] Univ Porto, I3S Inst Invest & Inovacao Saude, INEB Inst Biomed Engn, Rua Alfredo Allen 208, P-4200135 Porto, Portugal.
   [Matos, Andreia] Univ Porto, Abel Salazar Inst Biomed Sci ICBAS, Porto, Portugal.
   [Rebelo, Irene] Univ Porto, Fac Pharm, Dept Biol Sci, Biochem, Rua Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal.
   [Rebelo, Irene] Univ Porto, UCIBIO REQUIMTE, Porto, Portugal.
C3 Universidade de Lisboa; Universidade de Lisboa; Universidade de Lisboa;
   Universidade do Porto; i3S - Instituto de Investigacao e Inovacao em
   Saude, Universidade do Porto; Universidade do Porto; Universidade do
   Porto; Universidade do Porto
RP da Silva, IV (corresponding author), Univ Lisbon, Fac Farm, Ave Prof Gama Pinto, P-1649003 Lisbon, Portugal.
EM imsilva1@campus.ul.pt
RI Santos, Ana Carolina/GWR-2410-2022; Matos, Andreia/J-2410-2019; da
   Silva, Ines/ABH-6826-2020; Soveral, Graca/L-1550-2013
OI Oliveira, Alda Pereira da Silva/0000-0003-4496-2714; Soveral,
   Graca/0000-0001-8487-110X; Bicho, Manuel/0000-0002-5773-5687
FU Fundacao para a Ciencia e Tecnologia (FCT), Portugal [PD/BD/113634/2015,
   PTDC/BTM-SAL/28977/2017, UIDB/04138/2020, UIDP/04138/2020,
   UIDB/04378/2020]; Fundação para a Ciência e a Tecnologia
   [PD/BD/113634/2015] Funding Source: FCT
FX This research was funded by Fundacao para a Ciencia e Tecnologia (FCT),
   Portugal, through individual fellowship to IV da Silva
   (PD/BD/113634/2015), grant PTDC/BTM-SAL/28977/2017 and strategic
   projects UIDB/04138/2020 and UIDP/04138/2020 (iMed.ULisboa) and
   UIDB/04378/2020.
CR Agre P, 2004, ANGEW CHEM INT EDIT, V43, P4278, DOI 10.1002/anie.200460804
   Bertolotti M, 2013, ANTIOXID REDOX SIGN, V19, P1447, DOI 10.1089/ars.2013.5330
   Bienert GP, 2007, J BIOL CHEM, V282, P1183, DOI 10.1074/jbc.M603761200
   Brito R, 2015, EXP CLIN ENDOCR DIAB, V123, P325, DOI 10.1055/s-0035-1548765
   Brown MA, 2001, HYPERTENS PREGNANCY, V20, pIX, DOI 10.1081/PRG-100104165
   Carbrey Jennifer M, 2009, Handb Exp Pharmacol, P3, DOI 10.1007/978-3-540-79885-9_1
   Chen CW, 2014, CARDIOVASC RES, V101, P579, DOI 10.1093/cvr/cvu018
   da Silva IV, 2017, ADV EXP MED BIOL, V969, P227, DOI 10.1007/978-94-024-1057-0_15
   da Silva IV, 2018, CELL MOL LIFE SCI, V75, P1973, DOI 10.1007/s00018-018-2781-4
   Damiano A, 2001, PLACENTA, V22, P776, DOI 10.1053/plac.2001.0717
   Damiano AE, 2006, PLACENTA, V27, P1073, DOI 10.1016/j.placenta.2005.11.014
   Fukui T, 1997, CIRC RES, V80, P45, DOI 10.1161/01.RES.80.1.45
   Giachini FR, 2017, CURR HYPERTENS REP, V19, DOI 10.1007/s11906-017-0781-7
   Guzik TJ, 2000, CIRCULATION, V102, P1744
   HIGHTON J, 1984, J IMMUNOL METHODS, V68, P185, DOI 10.1016/0022-1759(84)90149-2
   Intapad S, 2013, CIRCULATION, V127, P668, DOI 10.1161/CIRCULATIONAHA.112.000677
   Kang S, 2015, ANTICANCER RES, V35, P2775
   LAHIRI DK, 1991, NUCLEIC ACIDS RES, V19, P5444, DOI 10.1093/nar/19.19.5444
   Mancia G, 2013, EUR HEART J, V34, P2159, DOI 10.1093/eurheartj/eht151
   Matos A, 2014, OBSTET GYNECOL INT, V2014, DOI 10.1155/2014/361727
   Matyar S, 2005, CLIN CHIM ACTA, V354, P153, DOI 10.1016/j.cccn.2004.11.022
   McDonald SD, 2013, ATHEROSCLEROSIS, V229, P234, DOI 10.1016/j.atherosclerosis.2013.04.020
   Miller EW, 2010, P NATL ACAD SCI USA, V107, P15681, DOI 10.1073/pnas.1005776107
   Miranda M, 2009, METABOLISM, V58, P1762, DOI 10.1016/j.metabol.2009.06.004
   Nejatizadeh A, 2008, BIOCHEM GENET, V46, P451, DOI 10.1007/s10528-008-9163-9
   Prudente S, 2007, DIABETES, V56, P1468, DOI 10.2337/db06-1389
   Redón J, 2003, HYPERTENSION, V41, P1096, DOI 10.1161/01.HYP.0000068370.21009.38
   Rodrigues C, 2019, CANCERS, V11, DOI 10.3390/cancers11070932
   Santovito A, 2012, MOL BIOL REP, V39, P6693, DOI 10.1007/s11033-012-1492-4
   Sies H, 2015, REDOX BIOL, V4, P180, DOI 10.1016/j.redox.2015.01.002
   Silberstein SD, 2004, CEPHALALGIA, V24, P2, DOI 10.1111/j.1468-2982.2004.00892.x
   Soveral G., 2016, Aquaporins in Health and Disease: New Molecular Targets for Drug Discovery
   Staff AC, 2011, PREGNANCY HYPERTENS, V1, P28, DOI 10.1016/j.preghy.2010.10.012
   Steegers EAP, 2010, LANCET, V376, P631, DOI 10.1016/S0140-6736(10)60279-6
   Szpilbarg N, 2017, PLACENTA, V59, P57, DOI 10.1016/j.placenta.2017.09.010
   Wang JY, 2018, INTERVIROLOGY, V61, P72, DOI 10.1159/000491601
   Watanabe S, 2016, BIOCHEM BIOPH RES CO, V471, P191, DOI 10.1016/j.bbrc.2016.01.153
   Xu QM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0084251
NR 38
TC 6
Z9 6
U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2210-7789
J9 PREGNANCY HYPERTENS
JI Pregnancy Hypertens.
PD JUN
PY 2021
VL 24
BP 44
EP 49
DI 10.1016/j.preghy.2021.02.008
EA FEB 2021
PG 6
WC Obstetrics & Gynecology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Cardiovascular System & Cardiology
GA SI2LM
UT WOS:000654657600006
PM 33652340
DA 2025-06-11
ER

PT J
AU Barandas, R
   Landgraf, D
   McCarthy, MJ
   Welsh, DK
AF Barandas, Rita
   Landgraf, Dominic
   McCarthy, Michael J.
   Welsh, David K.
TI Circadian Clocks as Modulators of Metabolic Comorbidity in Psychiatric
   Disorders
SO CURRENT PSYCHIATRY REPORTS
LA English
DT Review
DE Circadian rhythm; Psychiatric disorders; Metabolic syndrome; Depression;
   Reward; Obesity
ID PITUITARY-ADRENAL AXIS; BIPOLAR DISORDER; ENERGY-METABOLISM;
   DIURNAL-VARIATION; MAJOR DEPRESSION; LEPTIN CONCENTRATIONS; REWARD;
   DOPAMINE; TIME; OBESITY
AB Psychiatric disorders such as schizophrenia, bipolar disorder, and major depressive disorder are often accompanied by metabolic dysfunction symptoms, including obesity and diabetes. Since the circadian system controls important brain systems that regulate affective, cognitive, and metabolic functions, and neuropsychiatric and metabolic diseases are often correlated with disturbances of circadian rhythms, we hypothesize that dysregulation of circadian clocks plays a central role in metabolic comorbidity in psychiatric disorders. In this review paper, we highlight the role of circadian clocks in glucocorticoid, dopamine, and orexin/melanin-concentrating hormone systems and describe how a dysfunction of these clocks may contribute to the simultaneous development of psychiatric and metabolic symptoms.
C1 [Barandas, Rita] Ctr Hosp Lisboa Norte, Hosp Santa Maria, Dept Psychiat, Lisbon, Portugal.
   [Barandas, Rita] Univ Lisbon, Fac Med, P-1699 Lisbon, Portugal.
   [Barandas, Rita; Landgraf, Dominic; McCarthy, Michael J.; Welsh, David K.] VA San Diego Healthcare Syst Psychiat Serv, La Jolla, CA USA.
   [Barandas, Rita; Landgraf, Dominic; McCarthy, Michael J.; Welsh, David K.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
   [Barandas, Rita; Landgraf, Dominic; McCarthy, Michael J.; Welsh, David K.] Univ Calif San Diego, Ctr Circadian Biol, La Jolla, CA 92093 USA.
C3 Universidade de Lisboa; Hospital Santa Maria; Universidade de Lisboa; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   San Diego Healthcare System; University of California System; University
   of California San Diego; University of California System; University of
   California San Diego
RP Landgraf, D (corresponding author), VA San Diego Healthcare Syst Psychiat Serv, La Jolla, CA USA.
EM dlandgraf@ucsd.edu
RI ; McCarthy, Michael/K-9302-2017
OI Landgraf, Dominic/0000-0002-1328-1871; McCarthy,
   Michael/0000-0001-6219-4945
FU Veterans Affairs Merit Award [1I01BX001146]; NARSAD
FX Supported by a Veterans Affairs Merit Award (1I01BX001146) and a NARSAD
   Young Investigator Award to David K. Welsh. The authors declare no
   competing financial interests.
CR Abad Vivien C, 2005, Dialogues Clin Neurosci, V7, P291
   Abarca C, 2002, P NATL ACAD SCI USA, V99, P9026, DOI 10.1073/pnas.142039099
   Abrahamian H, 2012, NEUROPSYCH DIS TREAT, V8, P355, DOI 10.2147/NDT.S33679
   Abu Shamsi N, 2014, PHYSIOL BEHAV, V128, P188, DOI 10.1016/j.physbeh.2014.02.021
   Adamantidis A, 2009, J PHYSIOL-LONDON, V587, P33, DOI 10.1113/jphysiol.2008.164400
   Adeghate E, 2012, VITAM HORM, V89, P111, DOI 10.1016/B978-0-12-394623-2.00007-X
   Ahima RS, 1996, NATURE, V382, P250, DOI 10.1038/382250a0
   Albrecht U, 2012, NEURON, V74, P246, DOI 10.1016/j.neuron.2012.04.006
   Arble DM, 2009, OBESITY, V17, P2100, DOI 10.1038/oby.2009.264
   Aschbacher K, 2014, HYPOTHALAMIC PITUITA
   Baird AL, 2013, BRAIN RES, V1513, P61, DOI 10.1016/j.brainres.2013.03.038
   Barclay JL, 2013, AM J PHYSIOL-ENDOC M, V304, pE1053, DOI 10.1152/ajpendo.00512.2012
   Barclay JL, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0037150
   Baron KG, 2014, INT REV PSYCHIATR, V26, P139, DOI 10.3109/09540261.2014.911149
   Bass J, 2012, NATURE, V491, P348, DOI 10.1038/nature11704
   Bass J, 2010, SCIENCE, V330, P1349, DOI 10.1126/science.1195027
   Beeler JA, 2012, FRONT INTEGR NEUROSC, V6, DOI 10.3389/fnint.2012.00049
   Birchler-Pedross A, 2009, J BIOL RHYTHM, V24, P232, DOI 10.1177/0748730409335546
   Blouin AM, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms2461
   Boivin DB, 1997, ARCH GEN PSYCHIAT, V54, P145
   Bonnavion P, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms7266
   Boutrel B, 2010, BRAIN RES, V1314, P103, DOI 10.1016/j.brainres.2009.11.054
   Bray GA, 2014, BEST PRACT RES CL GA, V28, P665, DOI 10.1016/j.bpg.2014.07.015
   Bray MS, 2010, INT J OBESITY, V34, P1589, DOI 10.1038/ijo.2010.63
   Burdakov D, 2004, NEUROSCIENTIST, V10, P286, DOI 10.1177/1073858404263597
   Carvas JM, 2012, FRONT PHYSIOL, V3, DOI 10.3389/fphys.2012.00337
   Chung SJ, 2011, J MOL NEUROSCI, V43, P115, DOI 10.1007/s12031-010-9411-4
   Cleator J, 2012, NUTR DIABETES, V2, DOI 10.1038/nutd.2012.16
   Conductier G, 2011, NEUROSCIENCE, V178, P89, DOI 10.1016/j.neuroscience.2011.01.030
   Dallaspezia S, 2015, CURR PSYCHIAT REP, V17, DOI 10.1007/s11920-015-0606-9
   Dallmann R, 2006, J COMP PHYSIOL A, V192, P769, DOI 10.1007/s00359-006-0114-9
   De Bundel D, 2013, FRONT BEHAV NEUROSCI, V7, DOI 10.3389/fnbeh.2013.00152
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   de Kloet ER, 2005, NAT REV NEUROSCI, V6, P463, DOI 10.1038/nrn1683
   Depner CM, 2014, CURR DIABETES REP, V14, DOI 10.1007/s11892-014-0507-z
   Deurveilher S, 2005, NEUROSCIENCE, V130, P165, DOI 10.1016/j.neuroscience.2004.08.030
   Dibner C, 2010, ANNU REV PHYSIOL, V72, P517, DOI 10.1146/annurev-physiol-021909-135821
   Dickmeis T, 2013, MOL CELL ENDOCRINOL, V380, P2, DOI 10.1016/j.mce.2013.05.012
   Ferris MJ, 2014, P NATL ACAD SCI USA, V111, pE2751, DOI 10.1073/pnas.1407935111
   Forni D, 2014, GENOME BIOL, V15, DOI 10.1186/s13059-014-0499-7
   Garaulet M, 2014, PHYSIOL BEHAV, V134, P44, DOI 10.1016/j.physbeh.2014.01.001
   Garaulet M, 2013, NUTR HOSP, V28, P114, DOI 10.3305/nh.2013.28.sup5.6926
   García-Fuster MJ, 2012, EUR NEUROPSYCHOPHARM, V22, P607, DOI 10.1016/j.euroneuro.2011.12.001
   Gerhart-Hines Z, 2015, ENDOCR REV, V36, P289, DOI 10.1210/er.2015-1007
   Germain A, 2007, BIOL PSYCHIAT, V62, P438, DOI 10.1016/j.biopsych.2006.09.043
   Girault EM, 2012, PROG BRAIN RES, V198, P47, DOI 10.1016/B978-0-444-59489-1.00005-7
   Gonnissen HKJ, 2013, OBES REV, V14, P405, DOI 10.1111/obr.12019
   Gonnissen HKJ, 2012, AM J CLIN NUTR, V96, P689, DOI 10.3945/ajcn.112.037192
   Griebel G, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00049
   Grosbellet E, 2015, ENDOCRINOLOGY, V156, P1080, DOI 10.1210/en.2014-1570
   Guest PC, 2010, MOL PSYCHIATR, V15, P118, DOI 10.1038/mp.2009.81
   Hampp Gabriele, 2008, Commun Integr Biol, V1, P1
   Harris LW, 2013, PSYCHONEUROENDOCRINO, V38, P752, DOI 10.1016/j.psyneuen.2012.09.009
   Hasler BP, 2014, PSYCHIAT RES-NEUROIM, V224, P22, DOI 10.1016/j.pscychresns.2014.07.005
   Hatori M, 2012, CELL METAB, V15, P848, DOI 10.1016/j.cmet.2012.04.019
   Himmerich H, 2007, NEUROPSYCHOBIOLOGY, V55, P28, DOI 10.1159/000103573
   Hinkelmann K, 2012, PSYCHONEUROENDOCRINO, V37, P685, DOI 10.1016/j.psyneuen.2011.08.012
   Hood S, 2010, J NEUROSCI, V30, P14046, DOI 10.1523/JNEUROSCI.2128-10.2010
   Hopf FW, 2013, PEERJ, V1, DOI 10.7717/peerj.61
   Hryhorczuk C, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00177
   Jauch-Chara K, 2014, PROG NEUROBIOL, V114, P84, DOI 10.1016/j.pneurobio.2013.12.001
   Jordan SD, 2013, MOL CELL ENDOCRINOL, V366, P163, DOI 10.1016/j.mce.2012.06.017
   Kahl KG, 2015, BRAIN BEHAV, V5, DOI 10.1002/brb3.306
   Kalsbeek A, 2010, ANN NY ACAD SCI, V1212, P114, DOI 10.1111/j.1749-6632.2010.05800.x
   Kang SH, 2015, PSYCHIAT INVEST, V12, P242, DOI 10.4306/pi.2015.12.2.242
   Kayaba Y, 2003, AM J PHYSIOL-REG I, V285, pR581, DOI 10.1152/ajpregu.00671.2002
   Khanh DV, 2014, FRONT PSYCHOL, V5, DOI 10.3389/fpsyg.2014.00846
   Kiecolt-Glaser JK, 2015, BIOL PSYCHIAT, V77, P653, DOI 10.1016/j.biopsych.2014.05.018
   Kloiber S, 2013, EUR NEUROPSYCHOPHARM, V23, P653, DOI 10.1016/j.euroneuro.2012.08.010
   Kok P, 2006, J CLIN ENDOCR METAB, V91, P3236, DOI 10.1210/jc.2005-2529
   Kripke DF, 2011, EVID-BASED MENT HEAL, V14, P75, DOI 10.1136/ebmh.14.3.75
   Lamia KA, 2011, NATURE, V480, P552, DOI 10.1038/nature10700
   Lamont Elaine Waddington, 2007, Dialogues Clin Neurosci, V9, P333
   Lamont EW, 2010, ISR J PSYCHIATR REL, V47, P27
   Landgraf D, 2015, ELIFE, V4, DOI 10.7554/eLife.06253
   Landgraf D, 2014, CURR PSYCHIAT REP, V16, DOI 10.1007/s11920-014-0483-7
   Landgraf D, 2014, BEHAV NEUROSCI, V128, P344, DOI 10.1037/a0036029
   Landgraf D, 2012, PFLUG ARCH EUR J PHY, V463, P3, DOI 10.1007/s00424-011-1003-9
   Leinninger GM, 2011, PHYSIOL BEHAV, V104, P572, DOI 10.1016/j.physbeh.2011.04.060
   Levitan RD, 2012, J CLIN PSYCHIAT, V73, P1119, DOI 10.4088/JCP.11m07394
   Licinio J, 2014, TRANSL PSYCHIAT, V4, DOI 10.1038/tp.2014.115
   Lowrey PL, 2011, ADV GENET, V74, P175, DOI 10.1016/B978-0-12-387690-4.00006-4
   Lustman PJ, 2000, DIABETES CARE, V23, P934, DOI 10.2337/diacare.23.7.934
   Lutter M, 2009, J NUTR, V139, P629, DOI 10.3945/jn.108.097618
   Mansur RB, 2015, NEUROSCI BIOBEHAV R, V52, P89, DOI 10.1016/j.neubiorev.2014.12.017
   Marston OJ, 2008, MOL BRAIN, V1, DOI 10.1186/1756-6606-1-19
   McCarthy MJ, 2012, J BIOL RHYTHM, V27, P339, DOI 10.1177/0748730412456367
   McCarthy MJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0032091
   McClung CA, 2005, P NATL ACAD SCI USA, V102, P9377, DOI 10.1073/pnas.0503584102
   McHill AW, 2014, P NATL ACAD SCI USA, V111, P17302, DOI 10.1073/pnas.1412021111
   McIntyre Roger S, 2007, Ann Clin Psychiatry, V19, P257, DOI 10.1080/10401230701653377
   Mendoza J, 2014, NEUROSCIENCE, V282, P230, DOI 10.1016/j.neuroscience.2014.07.081
   Menet JS, 2011, CURR OPIN NEUROBIOL, V21, P849, DOI 10.1016/j.conb.2011.06.008
   Mignot E, 2002, NAT NEUROSCI, V5, P1071, DOI 10.1038/nn944
   Nestler EJ, 2006, BIOL PSYCHIAT, V59, P1151, DOI 10.1016/j.biopsych.2005.09.018
   Nicolaides NC, 2014, ANN NY ACAD SCI, V1318, P71, DOI 10.1111/nyas.12464
   Nollet M, 2013, CNS DRUGS, V27, P411, DOI 10.1007/s40263-013-0064-z
   Ohaeri JU, 2011, METAB SYNDR RELAT D, V9, P91, DOI 10.1089/met.2010.0053
   Oike Hideaki, 2014, Curr Nutr Rep, V3, P204
   Orozco-Solis R, 2014, NEUROSCIENCE, V264, P76, DOI 10.1016/j.neuroscience.2014.01.043
   Orozco-Solis R, 2014, CURR OPIN GENET DEV, V26, P66, DOI 10.1016/j.gde.2014.06.003
   Parekh PK, 2015, ALCOHOL, V49, P341, DOI 10.1016/j.alcohol.2014.09.034
   Parker KJ, 2003, HORM BEHAV, V43, P60, DOI 10.1016/S0018-506X(02)00016-8
   Ringen PA, 2014, FRONT PSYCHIATRY, V5, DOI 10.3389/fpsyt.2014.00137
   Robillard R, 2013, CURR PSYCHIAT REP, V15, DOI 10.1007/s11920-013-0402-3
   Roubos EW, 2012, GEN COMP ENDOCR, V177, P28, DOI 10.1016/j.ygcen.2012.01.009
   Roybal K, 2007, P NATL ACAD SCI USA, V104, P6406, DOI 10.1073/pnas.0609625104
   Rudic RD, 2004, PLOS BIOL, V2, P1893, DOI 10.1371/journal.pbio.0020377
   Rush AJ, 1996, J CLIN PSYCHIAT, V57, P470, DOI 10.4088/JCP.v57n1006
   Rutters F, 2014, J BIOL RHYTHM, V29, P377, DOI 10.1177/0748730414550199
   Salomon RM, 2003, BIOL PSYCHIAT, V54, P96, DOI 10.1016/S0006-3223(02)01740-7
   Sancar G, 2014, CELL MOL LIFE SCI, V71, P2667, DOI 10.1007/s00018-014-1574-7
   Sarnyai Z, 2015, BEHAV BRAIN RES, V276, P130, DOI 10.1016/j.bbr.2014.04.016
   Savalli G, 2015, AMINO ACIDS, V47, P1367, DOI 10.1007/s00726-015-1968-3
   Schibler U, 2003, J BIOL RHYTHM, V18, P250, DOI 10.1177/0748730403018003007
   Selbach O, 2006, CHRONOBIOL INT, V23, P63, DOI 10.1080/07420520500545961
   Shostak A, 2013, DIABETES, V62, P2195, DOI 10.2337/db12-1449
   Siegel JM, 2004, ANNU REV PSYCHOL, V55, P125, DOI 10.1146/annurev.psych.55.090902.141545
   Silver R, 2014, EUR J NEUROSCI, V39, P1866, DOI 10.1111/ejn.12593
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Soreca I, 2014, CURR OPIN PSYCHIATR, V27, P467, DOI 10.1097/YCO.0000000000000108
   Spinazzi R, 2006, PHARMACOL REV, V58, P46, DOI 10.1124/pr.58.1.4
   Stieg MR, 2015, PSYCHONEUROENDOCRINO, V51, P47, DOI 10.1016/j.psyneuen.2014.09.004
   Stokkan KA, 2001, SCIENCE, V291, P490, DOI 10.1126/science.291.5503.490
   Striegel-Moore RH, 2010, INT J EAT DISORDER, V43, P520, DOI 10.1002/eat.20735
   Terman M, 2005, CNS SPECTRUMS, V10, P647, DOI 10.1017/S1092852900019611
   Thompson JL, 2011, BEHAV BRAIN RES, V217, P446, DOI 10.1016/j.bbr.2010.09.028
   Thomsen KR, 2015, FRONT BEHAV NEUROSCI, V9, DOI 10.3389/fnbeh.2015.00049
   Tsang AH, 2014, J MOL ENDOCRINOL, V52, pR1, DOI 10.1530/JME-13-0118
   Tsujino N, 2013, FRONT BEHAV NEUROSCI, V7, DOI 10.3389/fnbeh.2013.00028
   Turek FW, 2005, SCIENCE, V308, P1043, DOI 10.1126/science.1108750
   Urbanavicius J, 2014, BEHAV PHARMACOL, V25, P316, DOI 10.1097/FBP.0000000000000056
   Vancampfort D, 2013, AM J PSYCHIAT, V170, P265, DOI 10.1176/appi.ajp.2012.12050620
   VITATERNA MH, 1994, SCIENCE, V264, P719, DOI 10.1126/science.8171325
   Vogelzangs N, 2011, J CLIN PSYCHIAT, V72, P598, DOI 10.4088/JCP.10m06559
   Webb IC, 2009, EUR J NEUROSCI, V30, P1739, DOI 10.1111/j.1460-9568.2009.06966.x
   Whitton AE, 2015, CURR OPIN PSYCHIATR, V28, P7, DOI 10.1097/YCO.0000000000000122
   Winsky-Sommerer R, 2004, J NEUROSCI, V24, P11439, DOI 10.1523/JNEUROSCI.3459-04.2004
   Wirz-Justice A, 2012, HAND CLINIC, V106, P697, DOI 10.1016/B978-0-444-52002-9.00042-5
   Wu JC, 2009, BIOL PSYCHIAT, V66, P298, DOI 10.1016/j.biopsych.2009.02.018
   Yan J, 2008, PLOS COMPUT BIOL, V4, DOI 10.1371/journal.pcbi.1000193
   Yang ST, 2009, ENDOCRINOLOGY, V150, P2153, DOI 10.1210/en.2008-0705
   Yujnovsky I, 2006, P NATL ACAD SCI USA, V103, P6386, DOI 10.1073/pnas.0510691103
   Zhang R, 2014, P NATL ACAD SCI USA, V111, P16219, DOI 10.1073/pnas.1408886111
NR 144
TC 53
Z9 54
U1 0
U2 34
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1523-3812
EI 1535-1645
J9 CURR PSYCHIAT REP
JI Curr. Psychiatry Rep.
PD DEC
PY 2015
VL 17
IS 12
AR 98
DI 10.1007/s11920-015-0637-2
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CZ0PI
UT WOS:000366807800006
PM 26483181
DA 2025-06-11
ER

PT J
AU Shiota, G
   Tsuchiya, H
AF Shiota, Goshi
   Tsuchiya, Hiroyuki
TI Pathophysiology of NASH: Insulin resistance, free fatty acids and
   oxidative stress
SO JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
LA English
DT Review
DE NASH; insulin resistance; free fatty acid; oxidative stress
ID NONALCOHOLIC STEATOHEPATITIS; NATURAL-HISTORY; LIVER-DISEASE; OBESITY;
   STEATOSIS; MODELS
AB Nonalcoholic steatohepatitis (NASH) is a clinicopathological condition that comprises a wide spectrum of liver damage, ranging from steatohepatitis, advanced fibrosis and cirrhosis. NASH is the most common liver disease in the United States, with a high prevalence in the obese, type 2 diabetic population and metabolic syndrome. Although the pathophysiology of NASH remains to be clarified, insulin resistance, free fatty acids and oxidative stress are the most important causes. In this review article, I focused on insulin resistance, free fatty acids and oxidative stress as main causes of NASH, and described the outlines of the pathophysiology of NASH.
C1 Tottori Univ, Div Med & Mol Genet, Dept Genet Med & Regenerat Therapeut, Grad Sch Med, Yonago, Tottori 6838504, Japan.
C3 Tottori University
RP Shiota, G (corresponding author), Tottori Univ, Div Med & Mol Genet, Dept Genet Med & Regenerat Therapeut, Grad Sch Med, Yonago, Tottori 6838504, Japan.
EM gshiota@grape.med.tottori-u.ac.jp
RI Tsuchiya, Hiroyuki/AEQ-0473-2022
CR Adams LA, 2005, GASTROENTEROLOGY, V129, P113, DOI 10.1053/j.gastro.2005.04.014
   Agarwal AK, 2002, NAT GENET, V31, P21, DOI 10.1038/ng880
   Angulo P, 2002, J GASTROEN HEPATOL, V17, pS186, DOI 10.1046/j.1440-1746.17.s1.10.x
   Browning JD, 2004, J CLIN INVEST, V114, P147, DOI 10.1172/JCI200422422
   Diehl AM, 2005, HEPATOL RES, V33, P138, DOI 10.1016/j.hepres.2005.09.022
   Feldstein AE, 2004, HEPATOLOGY, V40, P185, DOI 10.1002/hep.20283
   Fisher EA, 2002, J BIOL CHEM, V277, P17377, DOI 10.1074/jbc.R100068200
   GRAG A, 2002, J CLIN ENDOCR METAB, V87, P3019
   Hasegawa T, 2001, ALIMENT PHARM THERAP, V15, P1667, DOI 10.1046/j.1365-2036.2001.01083.x
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Kim JK, 2001, P NATL ACAD SCI USA, V98, P7522, DOI 10.1073/pnas.121164498
   Leung GK, 2000, J BIOL CHEM, V275, P7515, DOI 10.1074/jbc.275.11.7515
   LUDWIG J, 1980, MAYO CLIN PROC, V55, P434
   Neuschwander-Tetri BA, 2003, HEPATOLOGY, V37, P1202, DOI 10.1053/jhep.2003.50193
   Pessayre D, 2002, AM J PHYSIOL-GASTR L, V282, pG193, DOI 10.1152/ajpgi.00426.2001
   Pessayre D, 2001, SEMIN LIVER DIS, V21, P57, DOI 10.1055/s-2001-12929
   Portincasa P, 2005, CLIN BIOCHEM, V38, P203, DOI 10.1016/j.clinbiochem.2004.10.014
   Saltiel AR, 2001, NATURE, V414, P799, DOI 10.1038/414799a
   Sass DA, 2005, DIGEST DIS SCI, V50, P171, DOI 10.1007/s10620-005-1267-z
   Shackleton S, 2000, NAT GENET, V24, P153, DOI 10.1038/72807
   Shimano H, 1996, J CLIN INVEST, V98, P1575, DOI 10.1172/JCI118951
   Teli MR, 1995, HEPATOLOGY, V22, P1714, DOI 10.1016/0270-9139(95)90196-5
   Uysal KT, 1998, ENDOCRINOLOGY, V139, P4832, DOI 10.1210/en.139.12.4832
   Uysal KT, 1997, NATURE, V389, P610, DOI 10.1038/39335
   Yahagi N, 2002, J BIOL CHEM, V277, P19353, DOI 10.1074/jbc.M201584200
   Yuan MS, 2001, SCIENCE, V293, P1673, DOI 10.1126/science.1061620
NR 26
TC 12
Z9 15
U1 0
U2 13
PU JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
PI KYOTO
PA KYOTO PREFECTURAL UNIV MED, GRAD SCH MEDICAL SCIENCE, DEPT MOLECULAR
   GASTROENTEROLOGY & HEPATOLOGY, KYOTO, 602-8566, JAPAN
SN 0912-0009
EI 1880-5086
J9 J CLIN BIOCHEM NUTR
JI J. Clin. Biochem. Nutr.
PD MAY
PY 2006
VL 38
IS 3
BP 127
EP 132
DI 10.3164/jcbn.38.127
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 044AS
UT WOS:000237645000001
OA Bronze
DA 2025-06-11
ER

PT J
AU Jenkins, TA
AF Jenkins, Trisha A.
TI Metabolic Syndrome and Vascular-Associated Cognitive Impairment: a Focus
   on Preclinical Investigations
SO CURRENT DIABETES REPORTS
LA English
DT Review
DE Vascular cognitive impairment; Vascular dementia; Cognition;
   Hippocampus; Prefrontal cortex; Preclinical models
ID CHRONIC CEREBRAL HYPOPERFUSION; TERM ENVIRONMENTAL ENRICHMENT;
   INFLAMMATORY MARKERS; ALZHEIMERS-DISEASE; PREFRONTAL CORTEX; OXIDATIVE
   STRESS; RODENT MODELS; DEMENTIA; RAT; HIPPOCAMPAL
AB Purpose of Review Metabolic syndrome is associated with an increased risk of vascular cognitive impairment or, in the more extreme, vascular dementia. Animal models are used to investigate the relationship between pathology and behaviour. This review summarizes the latest understanding of the role of the hippocampus and prefrontal cortex in vascular cognitive impairment, the influence of inflammation in this association while also commenting on some of the latest interventions proposed. Recent Findings Models of vascular cognitive impairment and vascular dementia, whether they develop from an infarct or non-infarct base, demonstrate increased neuroinflammation, reduced neuronal function and deficits in prefrontal and hippocampal-associated cognitive domains. Promising new research shows agents and environmental interventions that inhibit central oxidative stress and inflammation can reverse both pathology and cognitive dysfunction. While preclinical studies suggest that reversal of deficits in vascular cognitive impairment models is possible, replication in patients still needs to be demonstrated.
C1 [Jenkins, Trisha A.] RMIT Univ, STEM Coll, Sch Hlth & Biomed Sci, Human Biosci, Plenty Rd, Bundoora, Vic 3083, Australia.
C3 Royal Melbourne Institute of Technology (RMIT)
RP Jenkins, TA (corresponding author), RMIT Univ, STEM Coll, Sch Hlth & Biomed Sci, Human Biosci, Plenty Rd, Bundoora, Vic 3083, Australia.
EM trisha.jenkins@rmitedu.au
RI Jenkins, Trisha/C-8649-2009
OI Jenkins, Trisha/0000-0003-0137-6643
FU CAUL
FX Open Access funding enabled and organized by CAUL and its Member
   Institutions
CR Aamodt K, 2010, PHYS REV LETT, V105, DOI 10.1103/PhysRevLett.105.252302
   Abraham WC, 2019, NPJ SCI LEARN, V4, DOI 10.1038/s41539-019-0048-y
   Alber J, 2019, ALZH DEMENT-TRCI, V5, P107, DOI 10.1016/j.trci.2019.02.001
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Fernandes FHA, 2016, CRIT REV ANAL CHEM, V46, P257, DOI 10.1080/10408347.2015.1095064
   Appleton JP, 2017, CLIN SCI, V131, P1561, DOI 10.1042/CS20160382
   Bales KL, 2007, DEV PSYCHOBIOL, V49, P335, DOI 10.1002/dev.20216
   Belkhelfa M, 2018, J NEUROIMMUNOL, V320, P48, DOI 10.1016/j.jneuroim.2018.04.004
   Bokura H, 2010, DEMENT GERIATR COGN, V30, P479, DOI 10.1159/000322057
   Bondan EF, 2019, ARQ NEURO-PSIQUIAT, V77, P601, DOI [10.1590/0004-282X20190091, 10.1590/0004-282x20190091]
   CACABELOS R, 1994, METHOD FIND EXP CLIN, V16, P141
   Cao DD, 2018, BIO-PROTOCOL, V8, DOI 10.21769/BioProtoc.2704
   Craggs LJL, 2014, NEUROPATH APPL NEURO, V40, P591, DOI 10.1111/nan.12073
   Diniz BS, 2013, BRIT J PSYCHIAT, V202, P329, DOI 10.1192/bjp.bp.112.118307
   Dong JT, 2018, NEUROL RES, V40, P68, DOI 10.1080/01616412.2017.1398389
   Du SQ, 2018, CNS NEUROSCI THER, V24, P39, DOI 10.1111/cns.12773
   Duncombe J, 2017, CLIN SCI, V131, P2451, DOI 10.1042/CS20160727
   Emsley HCA, 2005, J NEUROL NEUROSUR PS, V76, P1366, DOI 10.1136/jnnp.2004.054882
   Farkas E, 2007, BRAIN RES REV, V54, P162, DOI 10.1016/j.brainresrev.2007.01.003
   Fluri F, 2015, DRUG DES DEV THER, V9, P3445, DOI 10.2147/DDDT.S56071
   Foster V, 2014, BRAIN, V137, P2509, DOI 10.1093/brain/awu172
   Fu XB, 2014, PHARMACOL BIOCHEM BE, V126, P122, DOI 10.1016/j.pbb.2014.09.005
   Goodman RA, 2017, ALZHEIMERS DEMENT, V13, P28, DOI 10.1016/j.jalz.2016.04.002
   Gulpers B, 2016, AM J GERIAT PSYCHIAT, V24, P823, DOI 10.1016/j.jagp.2016.05.015
   Guo T, 2020, FRONT NEUROSCI-SWITZ, V14, DOI 10.3389/fnins.2020.00028
   Hort J, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20102405
   Ihara M, 2010, ACTA NEUROPATHOL, V119, P579, DOI 10.1007/s00401-009-0635-8
   Jalal FY, 2012, STROKE, V43, P1115, DOI 10.1161/STROKEAHA.111.643080
   Jiang P, 2019, J PHARMACOL SCI, V139, P105, DOI 10.1016/j.jphs.2018.12.003
   Jiwa NS, 2010, J NEUROCHEM, V115, P814, DOI 10.1111/j.1471-4159.2010.06958.x
   Kang ZC, 2020, DRUG DES DEV THER, V14, P3577, DOI 10.2147/DDDT.S249176
   Khoshnam SE, 2018, LIFE SCI, V211, P126, DOI 10.1016/j.lfs.2018.08.065
   Kim MS, 2016, J MED FOOD, V19, P196, DOI 10.1089/jmf.2015.3512
   Kimura S, 2000, TOXICOLOGY, V153, P167, DOI 10.1016/S0300-483X(00)00312-7
   Kitamura A, 2016, J CEREBR BLOOD F MET, V36, P1592, DOI 10.1177/0271678X15606717
   Koide M, 2021, J CLIN INVEST, V131, DOI 10.1172/JCI149029
   Kril JJ, 2002, J NEUROL NEUROSUR PS, V72, P747, DOI 10.1136/jnnp.72.6.747
   Kwitek AE, 2019, METHODS MOL BIOL, V2018, P269, DOI 10.1007/978-1-4939-9581-3_13
   Lee JM, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22126285
   Lee TK, 2019, NEURAL REGEN RES, V14, P1394, DOI 10.4103/1673-5374.253524
   Li F, 2018, BRAIN RES BULL, V140, P52, DOI 10.1016/j.brainresbull.2018.04.003
   Liang JM, 2013, MOLECULES, V18, P12777, DOI 10.3390/molecules181012777
   Lin YY, 2015, NEUROL RES, V37, P893, DOI 10.1179/1743132815Y.0000000074
   Liu YW, 2020, BIOL PHARM BULL, V43, P1315, DOI 10.1248/bpb.b20-00112
   Martinelli I, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10102528
   Metti AL, 2012, NEURODEGENER DIS MAN, V2, P609, DOI 10.2217/NMT.12.68
   Miller EK, 2001, ANNU REV NEUROSCI, V24, P167, DOI 10.1146/annurev.neuro.24.1.167
   Moghaddasi M, 2017, J PHYSIOL SCI, V67, P415, DOI 10.1007/s12576-016-0474-z
   Muller M, 2010, NEUROEPIDEMIOLOGY, V34, P83, DOI 10.1159/000264825
   Nabika T, 2012, HYPERTENS RES, V35, P477, DOI 10.1038/hr.2012.30
   Nguyen JCD, 2013, BEHAV BRAIN RES, V256, P598, DOI 10.1016/j.bbr.2013.09.004
   Nithianantharajah J, 2006, NAT REV NEUROSCI, V7, P697, DOI 10.1038/nrn1970
   Pappas BA, 1996, BRAIN RES, V708, P50, DOI 10.1016/0006-8993(95)01267-2
   Park JM, 2017, BIOL RES NURS, V19, P278, DOI 10.1177/1099800416686179
   Poh L, 2022, MOL NEURODEGENER, V17, DOI 10.1186/s13024-021-00506-8
   Poyrazoglu S, 2014, CURR OPIN ENDOCRINOL, V21, P56, DOI 10.1097/01.med.0000436414.90240.2c
   Ranasinghe P, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4041-1
   Ranieri F, 2012, J NEUROPHYSIOL, V107, P1868, DOI 10.1152/jn.00319.2011
   Ravaglia G, 2006, DIABETES CARE, V29, P2471, DOI 10.2337/dc06-0282
   Saito Hideya, 1995, Clinical and Experimental Pharmacology and Physiology, V22, pS257, DOI 10.1111/j.1440-1681.1995.tb02906.x
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Scuteri A, 2015, EUR J PREV CARDIOL, V22, P486, DOI 10.1177/2047487314525529
   Sherling DH, 2017, J CARDIOVASC PHARM T, V22, P365, DOI 10.1177/1074248416686187
   Sinha K, 2020, DRUG DISCOV TODAY, V25, P793, DOI 10.1016/j.drudis.2020.01.003
   Smith EE, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.117.005568
   Song MK, 2020, BRAIN RES BULL, V163, P160, DOI 10.1016/j.brainresbull.2020.07.020
   Spencer SJ, 2017, NEUROBIOL AGING, V58, P88, DOI 10.1016/j.neurobiolaging.2017.06.014
   Staessen JA, 2011, HYPERTENSION, V57, pE6, DOI 10.1161/HYPERTENSIONAHA.110.165142
   Szkudelski T, 2001, PHYSIOL RES, V50, P537
   Tomassoni D, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051356
   Tuo QZ, 2017, MOL PSYCHIATR, V22, P1520, DOI 10.1038/mp.2017.171
   Ueno M, 2009, HYPERTENS RES, V32, P332, DOI 10.1038/hr.2009.26
   van de Pol L, 2011, NEURODEGENER DIS, V8, P465, DOI 10.1159/000326695
   van der Flier WM, 2018, NAT REV DIS PRIMERS, V4, DOI 10.1038/nrdp.2018.3
   Vijayakumar Avinash, 2013, ISRN Radiol, V2013, P174524, DOI 10.5402/2013/174524
   Wang L, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/8253904
   Wang XX, 2020, EUR REV MED PHARMACO, V24, P9601, DOI 10.26355/eurrev_202009_23048
   Ward R, 2019, PHARMACOL RES, V142, P237, DOI 10.1016/j.phrs.2019.01.035
   Wasser CR, 2017, J BIOL CHEM, V292, P1330, DOI 10.1074/jbc.R116.766782
   YAMAGUCHI M, 1994, ACTA NEUROCHIR, P200
   Yang Y, 2016, TRANSL STROKE RES, V7, P407, DOI 10.1007/s12975-016-0486-2
   Yates KF, 2012, ARTERIOSCL THROM VAS, V32, P2060, DOI 10.1161/ATVBAHA.112.252759
   Ye TY, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19123977
   Yermakov LM, 2018, FRONT CELL NEUROSCI, V12, DOI 10.3389/fncel.2018.00146
   Zhang LL, 2020, BEHAV BRAIN RES, V388, DOI 10.1016/j.bbr.2020.112648
   Zhang SY, 2019, METAB BRAIN DIS, V34, P309, DOI 10.1007/s11011-018-0356-6
   Zhou RB, 2010, NAT IMMUNOL, V11, P136, DOI 10.1038/ni.1831
NR 87
TC 8
Z9 8
U1 2
U2 18
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1534-4827
EI 1539-0829
J9 CURR DIABETES REP
JI Curr. Diabetes Rep.
PD AUG
PY 2022
VL 22
IS 8
BP 333
EP 340
DI 10.1007/s11892-022-01475-y
EA JUN 2022
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 3E4GP
UT WOS:000814955400002
PM 35737273
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Bonnefont-Rousselot, D
AF Bonnefont-Rousselot, Dominique
TI Obesity and Oxidative Stress: Potential Roles of Melatonin as
   Antioxidant and Metabolic Regulator
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Article
DE Antioxidant; insulin resistance; melatonin; metabolic syndrome; obesity
ID BROWN ADIPOSE-TISSUE; KINASE-C-BETA; NECROSIS-FACTOR-ALPHA; HIGH-FAT
   DIET; REACTIVE OXYGEN; GLUTATHIONE-PEROXIDASE; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; BODY-WEIGHT; ADIPOCYTE DIFFERENTIATION
AB Obesity is associated with an oxidative stress status, defined as an excessive production of reactive oxygen species (ROS) compared to the level of antioxidants acting in the natural defence systems. Several sources of ROS can be identified in obesity (e. g., mitochondrial respiratory chain, or NADPH oxidase) and could contribute to the pathogenesis of obesity. Indeed, these conditions favour the development of insulin resistance and metabolic syndrome through deregulation of adipokines and pro-inflammatory cytokines, so that it could be of interest to associate antioxidant therapeutic strategies with strategies of weight loss. Among antioxidants, melatonin holds a special place, on the one hand for its antioxidant and anti-inflammatory properties, and on the other hand for its role as a metabolic regulator. As melatonin modulates several processes involved in obesity and its related metabolic alterations, it could have a therapeutic interest in the treatment of obesity.
C1 [Bonnefont-Rousselot, Dominique] Grp Hosp Pitie Salpetriere, AP HP, Serv Biochim Metab, F-75651 Paris 13, France.
   [Bonnefont-Rousselot, Dominique] Univ Paris 06, INSERM, ICAN, UMR S 1166, F-75013 Paris, France.
   [Bonnefont-Rousselot, Dominique] Univ Paris 05, Fac Pharm, F-75006 Paris, France.
C3 Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Pitie-Salpetriere - APHP; Sorbonne Universite; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Sorbonne Universite;
   Universite Paris Cite
RP Bonnefont-Rousselot, D (corresponding author), Grp Hosp Pitie Salpetriere, AP HP, Serv Biochim Metab, 47-83 Blvd Hop, F-75651 Paris 13, France.
EM dominique.rousselot@psl.aphp.fr
RI Rousselot, Bonnefont/U-7434-2019
OI Bonnefont-Rousselot, Dominique/0000-0003-4689-9202
CR Alfadda AA, 2012, J BIOMED BIOTECHNOL, DOI 10.1155/2012/936486
   Anderson EJ, 2009, J CLIN INVEST, V119, P573, DOI 10.1172/JCI37048
   Angelico F, 2012, INTERN EMERG MED, V7, P219, DOI 10.1007/s11739-011-0591-x
   [Anonymous], 2011, J EXP INTEG MED
   [Anonymous], J EXP INTEGR MED
   ASTRUP A, 1985, AM J PHYSIOL, V248, pE507, DOI 10.1152/ajpendo.1985.248.5.E507
   Atilgan D, 2013, ADV UROL, V2013, DOI 10.1155/2013/836121
   Au-Yong ITH, 2009, DIABETES, V58, P2583, DOI 10.2337/db09-0833
   Bansode RR, 2008, J BIOL CHEM, V283, P231, DOI 10.1074/jbc.M707268200
   BARLOWWALDEN LR, 1995, NEUROCHEM INT, V26, P497, DOI 10.1016/0197-0186(94)00154-M
   Bastard JP, 2000, DIABETES-METAB RES, V16, P192, DOI 10.1002/1520-7560(200005/06)16:3<192::AID-DMRR114>3.0.CO;2-G
   Basu S, 2001, ANN RHEUM DIS, V60, P627, DOI 10.1136/ard.60.6.627
   Berniakovich I, 2008, J BIOL CHEM, V283, P34283, DOI 10.1074/jbc.M804362200
   Bisbal C, 2010, CURR OPIN CLIN NUTR, V13, P439, DOI 10.1097/MCO.0b013e32833a5559
   Bjelakovic G, 2007, JAMA-J AM MED ASSOC, V297, P842, DOI 10.1001/jama.297.8.842
   Block G, 2002, AM J EPIDEMIOL, V156, P274, DOI 10.1093/aje/kwf029
   Bonnefont-Rousselot D, 2002, CURR OPIN CLIN NUTR, V5, P561, DOI 10.1097/00075197-200209000-00016
   Bonnefont-Rousselot D, 2011, J PINEAL RES, V50, P328, DOI 10.1111/j.1600-079X.2010.00847.x
   Bonnefont-Rousselot D, 2010, TOXICOLOGY, V278, P55, DOI 10.1016/j.tox.2010.04.008
   BONNEFONTROUSSE.D, 2004, METAB HORM DIAB NUTR, V3, P107
   Brzezinski Amnon, 1997, New England Journal of Medicine, V336, P186
   Calzadilla P, 2011, INT J MOL SCI, V12, P6936, DOI 10.3390/ijms12106936
   Cannon B, 2004, PHYSIOL REV, V84, P277, DOI 10.1152/physrev.00015.2003
   Cardinali DP, 2013, INT J MOL SCI, V14, P2502, DOI 10.3390/ijms14022502
   Alonso-Vale MIC, 2009, J PINEAL RES, V47, P221, DOI 10.1111/j.1600-079X.2009.00705.x
   Choi HD, 2011, PHYTOTHER RES, V25, P1813, DOI 10.1002/ptr.3494
   Chrysohoou C, 2007, NUTR METAB CARDIOVAS, V17, P590, DOI 10.1016/j.numecd.2006.05.007
   Cipolla-Neto J, 2014, J PINEAL RES, V56, P371, DOI 10.1111/jpi.12137
   Coto-Montes A, 2012, MOL CELL ENDOCRINOL, V361, P12, DOI 10.1016/j.mce.2012.04.009
   Cracowski JL, 2002, AM J GASTROENTEROL, V97, P99
   Curtis R, 2005, NAT REV DRUG DISCOV, V4, P569, DOI 10.1038/nrd1777
   Cypess AM, 2009, NEW ENGL J MED, V360, P1509, DOI 10.1056/NEJMoa0810780
   Davì G, 2002, JAMA-J AM MED ASSOC, V288, P2008, DOI 10.1001/jama.288.16.2008
   de Ferranti S, 2002, CLIN CHIM ACTA, V317, P1, DOI 10.1016/S0009-8981(01)00797-5
   De Marchi E, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/564961
   de Onis M, 2010, AM J CLIN NUTR, V92, P1257, DOI 10.3945/ajcn.2010.29786
   de Vries HE, 2008, FREE RADICAL BIO MED, V45, P1375, DOI 10.1016/j.freeradbiomed.2008.09.001
   DELUXNDELGADO B, 2013, J PINEAL RES
   Deng WG, 2006, BLOOD, V108, P518, DOI 10.1182/blood-2005-09-3691
   DESCI T, 1997, J PEDIATR, V130, P653
   Dominguez-Rodriguez A, 2009, CURR VASC PHARMACOL, V7, P367, DOI 10.2174/157016109788340749
   Eckel RH, 2002, CIRCULATION, V105, P2923, DOI 10.1161/01.CIR.0000017823.53114.4C
   El-Missiry MA, 2012, CURRENT TOPICS IN IONIZING RADIATION RESEARCH, P443
   Esposito E, 2010, CURR NEUROPHARMACOL, V8, P228, DOI 10.2174/157015910792246155
   Favero G, 2014, MOL CELL ENDOCRINOL, V382, P926, DOI 10.1016/j.mce.2013.11.016
   Finucane MM, 2011, LANCET, V377, P557, DOI 10.1016/S0140-6736(10)62037-5
   Fleming I, 1998, BIOCHEM J, V333, P719, DOI 10.1042/bj3330719
   Franco JG, 2013, J NUTR BIOCHEM, V24, P960, DOI 10.1016/j.jnutbio.2012.06.019
   Fung TT, 2000, AM J EPIDEMIOL, V152, P1171, DOI 10.1093/aje/152.12.1171
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gaens KH, 2010, EXPERT REV ENDOCRINO, V5, P839, DOI 10.1586/EEM.10.68
   Galano A, 2011, J PINEAL RES, V51, P1, DOI 10.1111/j.1600-079X.2011.00916.x
   Gao X, 2007, DIABETES CARE, V30, P694, DOI 10.2337/dc06-1835
   Gardès-Albert M, 2003, ACTUAL CHIMIQUE, P91
   Giorgi C, 2010, ANTIOXID REDOX SIGN, V13, P1051, DOI 10.1089/ars.2009.2825
   Grimsrud PA, 2007, MOL CELL PROTEOMICS, V6, P624, DOI 10.1074/mcp.M600120-MCP200
   HAUSMAN DB, 2008, FOOD LIPIDS CHEM NUT, P601
   Higdon JV, 2003, ARTERIOSCL THROM VAS, V23, P365, DOI 10.1161/01.ATV.0000063608.43095.E2
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Huang W, 2009, HEPATOLOGY, V49, P1525, DOI 10.1002/hep.22815
   Hulsmans M, 2012, CURR ATHEROSCLER REP, V14, P264, DOI 10.1007/s11883-012-0237-0
   Jaffe Russell, 2009, P281
   Jiménez-Aranda A, 2013, J PINEAL RES, V55, P416, DOI 10.1111/jpi.12089
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Kedziora-Kornatowska K, 2009, J PINEAL RES, V46, P333, DOI 10.1111/j.1600-079X.2009.00666.x
   Kim JR, 2006, EXP MOL MED, V38, P162, DOI 10.1038/emm.2006.20
   Kopelman PG, 2000, NATURE, V404, P635, DOI 10.1038/35007508
   Korkmaz A, 2012, GENE, V503, P1, DOI 10.1016/j.gene.2012.04.040
   Korkmaz A, 2009, REV ENDOCR METAB DIS, V10, P261, DOI 10.1007/s11154-009-9117-5
   Koziróg M, 2011, J PINEAL RES, V50, P261, DOI 10.1111/j.1600-079X.2010.00835.x
   Kücükakin B, 2009, J SURG RES, V152, P338, DOI 10.1016/j.jss.2007.12.753
   Kusminski CM, 2012, NAT MED, V18, P1539, DOI 10.1038/nm.2899
   Lamont KT, 2011, J PINEAL RES, V50, P374, DOI 10.1111/j.1600-079X.2010.00853.x
   Lee H, 2009, J BIOL CHEM, V284, P10601, DOI 10.1074/jbc.M808742200
   Li JH, 2005, MEDIAT INFLAMM, P185, DOI 10.1155/MI.2005.185
   Li WG, 2010, NUCLEIC ACIDS RES, V38, P778, DOI 10.1093/nar/gkp1048
   Li WG, 2009, MOL CARCINOGEN, V48, P91, DOI 10.1002/mc.20465
   Liang HY, 2006, ADV PHYSIOL EDUC, V30, P145, DOI 10.1152/advan.00052.2006
   Loffredo L, 2012, J PEDIATR-US, V161, P1004, DOI 10.1016/j.jpeds.2012.05.042
   Gálvez MIL, 2011, CURR PHARM BIOTECHNO, V12, P386
   Mahadev K, 2004, MOL CELL BIOL, V24, P1844, DOI 10.1128/MCB.24.5.1844-1854.2004
   Markwald RR, 2013, P NATL ACAD SCI USA, V110, P5695, DOI 10.1073/pnas.1216951110
   Matsuoka T, 1997, J CLIN INVEST, V99, P144, DOI 10.1172/JCI119126
   Matsuzawa Y, 1999, ANN NY ACAD SCI, V892, P146, DOI 10.1111/j.1749-6632.1999.tb07793.x
   Mauriz JL, 2013, J PINEAL RES, V54, P1, DOI 10.1111/j.1600-079X.2012.01014.x
   Miller ER, 2005, ANN INTERN MED, V142, P37, DOI 10.7326/0003-4819-142-1-200501040-00110
   Mohamed-Ali V, 1997, J CLIN ENDOCR METAB, V82, P4196, DOI 10.1210/jc.82.12.4196
   Morrow JD, 2000, DRUG METAB REV, V32, P377, DOI 10.1081/DMR-100102340
   NAKAZONO K, 1991, P NATL ACAD SCI USA, V88, P10045, DOI 10.1073/pnas.88.22.10045
   Nduhirabandi F, 2012, ACTA PHYSIOL, V205, P209, DOI 10.1111/j.1748-1716.2012.02410.x
   OHARA Y, 1993, J CLIN INVEST, V91, P2546, DOI 10.1172/JCI116491
   Okamoto Y, 2002, CIRCULATION, V106, P2767, DOI 10.1161/01.CIR.0000042707.50032.19
   Olusi SO, 2002, INT J OBESITY, V26, P1159, DOI 10.1038/sj.ijo.0802066
   Pablos MI, 1995, J PINEAL RES, V19, P111, DOI 10.1111/j.1600-079X.1995.tb00178.x
   Pablos MI, 1998, NEUROCHEM INT, V32, P69, DOI 10.1016/S0197-0186(97)00043-0
   Pan M, 2006, J PINEAL RES, V41, P79, DOI 10.1111/j.1600-079X.2006.00346.x
   Park HS, 2009, BIOFACTORS, V35, P373, DOI 10.1002/biof.38
   Peschke E, 2007, J PINEAL RES, V42, P350, DOI 10.1111/j.1600-079X.2007.00426.x
   Peschke E, 2013, INT J MOL SCI, V14, P6981, DOI 10.3390/ijms14046981
   Peyrot F, 2008, J PINEAL RES, V45, P235, DOI 10.1111/j.1600-079X.2008.00580.x
   Pihl E, 2006, INT J OBESITY, V30, P141, DOI 10.1038/sj.ijo.0803068
   Pinton P, 2007, SCIENCE, V315, P659, DOI 10.1126/science.1135380
   Pipek Ruben, 1996, Journal of Nutritional and Environmental Medicine (Abingdon), V6, P267, DOI 10.3109/13590849609007253
   Prunet-Marcassus B, 2003, ENDOCRINOLOGY, V144, P5347, DOI 10.1210/en.2003-0693
   Puchalski SS, 2003, ENDOCRINE, V21, P163, DOI 10.1385/ENDO:21:2:163
   Radogna F, 2010, BIOCHEM PHARMACOL, V80, P1844, DOI 10.1016/j.bcp.2010.07.041
   Rasmussen DD, 1999, ENDOCRINOLOGY, V140, P1009, DOI 10.1210/en.140.2.1009
   REITER RJ, 1991, ENDOCR REV, V12, P151, DOI 10.1210/edrv-12-2-151
   Reiter RJ, 2004, POL J PHARMACOL, V56, P159
   Reiter RJ, 2012, ANN MED, V44, P564, DOI 10.3109/07853890.2011.586365
   Reiter RJ, 2009, CRIT REV BIOCHEM MOL, V44, P175, DOI 10.1080/10409230903044914
   Riccioni G, 2012, NUTRITION, V28, P605, DOI 10.1016/j.nut.2011.11.028
   Rigoulet M, 2011, ANTIOXID REDOX SIGN, V14, P459, DOI 10.1089/ars.2010.3363
   Roh C, 2012, MOLECULES, V17, P3630, DOI 10.3390/molecules17043630
   Rudich A, 1998, DIABETES, V47, P1562, DOI 10.2337/diabetes.47.10.1562
   Saito M, 2009, DIABETES, V58, P1526, DOI 10.2337/db09-0530
   SALAZAR DE, 1994, INT J OBESITY, V18, P25
   Sari I, 2010, NUTRITION, V26, P399, DOI 10.1016/j.nut.2009.05.023
   Shimomura I, 1996, NAT MED, V2, P800, DOI 10.1038/nm0796-800
   Spiegelman BM, 2001, CELL, V104, P531, DOI 10.1016/S0092-8674(01)00240-9
   Srinivasan V, 2013, RECENT PATENTS ENDOC, V7, P11, DOI 10.2174/187221413804660953
   Stowe DF, 2009, ANTIOXID REDOX SIGN, V11, P1373, DOI 10.1089/ARS.2008.2331
   Strauss RS, 1999, J PEDIATR-US, V134, P160, DOI 10.1016/S0022-3476(99)70409-9
   Tain YL, 2013, PEDIATR RES, V73, P395, DOI 10.1038/pr.2012.203
   Tan DX, 2011, OBES REV, V12, P167, DOI 10.1111/j.1467-789X.2010.00756.x
   Tan DX, 2007, J PINEAL RES, V42, P28, DOI 10.1111/j.1600-079X.2006.00407.x
   Vazzana N, 2012, J CLIN ENDOCR METAB, V97, pE1726, DOI 10.1210/jc.2012-1473
   Violi F, 2009, FUTUR CARDIOL, V5, P83, DOI 10.2217/14796678.5.1.83
   Vivekananthan DP, 2003, LANCET, V361, P2017, DOI 10.1016/S0140-6736(03)13637-9
   Wang YF, 2012, INT REV PSYCHIATR, V24, P176, DOI 10.3109/09540261.2012.688195
   Wellen KE, 2010, MOL CELL, V40, P323, DOI 10.1016/j.molcel.2010.10.004
   Winiarska K, 2006, J PINEAL RES, V40, P168, DOI 10.1111/j.1600-079X.2005.00295.x
   Wolden-Hanson T, 2000, ENDOCRINOLOGY, V141, P487, DOI 10.1210/en.141.2.487
   Wozniak SE, 2009, DIGEST DIS SCI, V54, P1847, DOI 10.1007/s10620-008-0585-3
   Yamauchi T, 2001, NAT MED, V7, P941, DOI 10.1038/90984
   Younce CW, 2010, BIOCHEM J, V426, P43, DOI 10.1042/BJ20090976
   Zhang LM, 2010, J PINEAL RES, V49, P364, DOI 10.1111/j.1600-079X.2010.00803.x
   Zhang Y, 2012, PHARMACOL RES, V66, P505, DOI 10.1016/j.phrs.2012.09.004
   Ziccardi P, 2002, CIRCULATION, V105, P804, DOI 10.1161/hc0702.104279
   Zingaretti MC, 2009, FASEB J, V23, P3113, DOI 10.1096/fj.09-133546
NR 140
TC 28
Z9 30
U1 1
U2 12
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2014
VL 14
IS 3
BP 159
EP 168
DI 10.2174/1871530314666140604151452
PG 10
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA CA1CP
UT WOS:000348651000001
PM 24934925
DA 2025-06-11
ER

PT J
AU Ghanbarijolfaie, A
   Pirhayati, M
   Mazaheri, M
   Naderi, Z
   Eftekhar, M
   Chegini, L
AF Ghanbarijolfaie, Atefeh
   Pirhayati, Mohammad
   Mazaheri, Maryam
   Naderi, Zahra
   Eftekhar, Mehrdad
   Chegini, Leila
TI Obesity, marital satisfaction and depression affect Iranian female
   sexual function
SO SEXUAL AND RELATIONSHIP THERAPY
LA English
DT Article
DE Obesity; body mass index; female sexual function index; ENRICH marital;
   Satisfaction Scale; Beck Depression Inventory
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; BODY-WEIGHT; INDEX FSFI;
   DYSFUNCTION; WOMEN; HEALTH; PREVALENCE; GENDER; MEN
AB The current study aimed to evaluate the effects of obesity on Iranian female sexual dysfunction (FSD). Married women were included in two groups of patients with Body Mass Index BMI >= 30 and control with normal BMI. The two groups were compared using the Female Sexual Function Index (FSFI), ENRICH Marital Satisfaction Scale, and Beck Depression Inventory (BDI). The correlations between BMI, marital satisfaction, depression, age, education marriage duration, and FSFI were analyzed using a linear regression test and correlation analysis. The FSFI scores in both groups were done. Despite the desire, other domains of FSFI showed significant differences among the groups. The mean of the ENRICH Marital Satisfaction Scale in test and control groups was evaluated. Also, BDI showed significant differences among both groups. Moreover, FSFI showed a direct correlation with ENRICH and an inverse correlation with BDI. Consequently, according to the results, obesity can influence the Iranian FSD.
C1 [Ghanbarijolfaie, Atefeh] Iran Univ Med Sci, Psychiat Res Dept, Tehran, Iran.
   [Pirhayati, Mohammad] Iran Univ Med Sci, Gen Med Dept, Dept Neurol, Tehran, Iran.
   [Mazaheri, Maryam; Eftekhar, Mehrdad] Iran Univ Med Sci, Mental Hlth Res Ctr, Tehran, Iran.
   [Naderi, Zahra] Iran Univ Med Sci, Obstet & Gynecol Dept, Tehran, Iran.
C3 Iran University of Medical Sciences; Iran University of Medical
   Sciences; Iran University of Medical Sciences; Iran University of
   Medical Sciences
RP Chegini, L (corresponding author), AJA Univ Med Sci, Internal Med Dept, Tehran, Iran.
EM leychegini@gmail.com
RI naderi, zahra/AAE-5918-2022
CR Adolfsson B, 2004, OBES RES, V12, P1702, DOI 10.1038/oby.2004.211
   Assimakopoulos K, 2006, OBES SURG, V16, P1087, DOI 10.1381/096089206778026442
   Assimakopoulos K, 2011, OBES SURG, V21, P362, DOI 10.1007/s11695-010-0303-z
   Atlantis E, 2008, INT J OBESITY, V32, P881, DOI 10.1038/ijo.2008.54
   Aydin M, 2015, UROL J, V12, P2339
   Bahrami H, 2006, BMC PUBLIC HEALTH, V6, DOI 10.1186/1471-2458-6-158
   Bajos Nathalie, 2010, BMJ, V340, pc2573, DOI 10.1136/bmj.c2573
   Bates JN, 2019, CURR SEX HEALTH REP, V11, P52, DOI 10.1007/s11930-019-00192-0
   Bathaee H., 1977, ACTA MED IRANICA, V1, P45
   BECK AT, 1988, CLIN PSYCHOL REV, V8, P77, DOI 10.1016/0272-7358(88)90050-5
   Bond DS, 2011, SURG OBES RELAT DIS, V7, P1, DOI 10.1016/j.soard.2010.05.015
   Bond DS, 2009, SURG OBES RELAT DIS, V5, P698, DOI 10.1016/j.soard.2009.07.004
   Brody S, 2004, J SEX MARITAL THER, V30, P251, DOI 10.1080/00926230490422368
   Chedraui P, 2012, MATURITAS, V71, P407, DOI 10.1016/j.maturitas.2012.01.013
   Chedraui P, 2011, MATURITAS, V68, P387, DOI 10.1016/j.maturitas.2010.12.004
   Clayton Anita H, 2002, Curr Womens Health Rep, V2, P182
   Dehghankar L, 2022, J EDUC HEALTH PROMOT, V11, DOI 10.4103/jehp.jehp_414_21
   Dixon JB, 2001, OBES RES, V9, P713, DOI 10.1038/oby.2001.96
   Dunn KM, 1999, J EPIDEMIOL COMMUN H, V53, P144, DOI 10.1136/jech.53.3.144
   Edwards WM, 2004, ARCH SEX BEHAV, V33, P189, DOI 10.1023/B:ASEB.0000026619.95734.d5
   Esposito K, 2004, JAMA-J AM MED ASSOC, V291, P2978, DOI 10.1001/jama.291.24.2978
   Esposito K, 2008, INT J IMPOT RES, V20, P358, DOI 10.1038/ijir.2008.9
   Esposito K, 2007, INT J IMPOT RES, V19, P353, DOI 10.1038/sj.ijir.3901548
   Esposito K, 2005, INT J IMPOT RES, V17, P224, DOI 10.1038/sj.ijir.3901310
   FOWERS BJ, 1991, SEX ROLES, V24, P209, DOI 10.1007/BF00288892
   FRANK E, 1978, NEW ENGL J MED, V299, P111, DOI 10.1056/NEJM197807202990302
   Heyman R.E., 1994, J FAM PSYCHOL, V8, P432, DOI [DOI 10.1037/0893-3200.8.4.432, DOI 10.1002/jts.20334]
   Jaafarpour M, 2013, J CLIN DIAGN RES, V7, P2877, DOI 10.7860/JCDR/2013/6813.3822
   Javadnoori M., 2015, MATURITAS, V81, P202, DOI [https://doi.org/10.1016/j.maturitas.2015.02.297, DOI 10.1016/J.MATURITAS.2015.02.297]
   Kadioglu P, 2010, BJU INT, V106, P1357, DOI 10.1111/j.1464-410X.2010.09348.x
   Karimi Fatemeh Zahra, 2020, Zahedan Journal of Research in Medical Sciences, V22, DOI 10.5812/zjrms.77180
   Kinzl JF, 2001, OBES SURG, V11, P455, DOI 10.1381/096089201321209323
   Kirchengast S, 1996, MATURITAS, V23, P63, DOI 10.1016/0378-5122(95)00954-X
   Kolotkin RL, 2006, OBESITY, V14, P472, DOI 10.1038/oby.2006.62
   Larsen SH, 2007, INT J OBESITY, V31, P1189, DOI 10.1038/sj.ijo.0803604
   Laumann EO, 2005, INT J IMPOT RES, V17, P39, DOI 10.1038/sj.ijir.3901250
   Laumann EO, 1999, JAMA-J AM MED ASSOC, V281, P537, DOI 10.1001/jama.281.6.537
   Macas J. A. G., 2004, GERMAN J PSYCHIAT
   MATHEW RJ, 1982, ARCH SEX BEHAV, V11, P323, DOI 10.1007/BF01541593
   Mathus-Vliegen EMH, 2007, BRIT J SURG, V94, P457, DOI 10.1002/bjs.5607
   McElroy SL, 2004, J CLIN PSYCHIAT, V65, P634
   Mirghafourvand M, 2018, COMMUNITY MENT HLT J, V54, P1274, DOI 10.1007/s10597-017-0188-6
   Mirghafourvand M, 2016, APPL RES QUAL LIFE, V11, P723, DOI 10.1007/s11482-015-9392-0
   MohammadiKh H. M., 2008, PAYESH, V7, P269
   Mozafari M, 2015, IRAN RED CRESCENT ME, V17, DOI 10.5812/ircmj.24685
   Muennig P, 2006, AM J PUBLIC HEALTH, V96, P1662, DOI 10.2105/AJPH.2005.068874
   Nagelkerke NJD, 2006, BMC PUBLIC HEALTH, V6, DOI 10.1186/1471-2458-6-199
   Oh SJ, 2008, INT J UROL, V15, P62, DOI 10.1111/j.1442-2042.2007.01905.x
   Osinowo H O, 2003, West Afr J Med, V22, P225
   Otunctemur A, 2015, J SEX MARITAL THER, V41, P440, DOI 10.1080/0092623X.2014.918068
   Panahi Rahman, 2021, J Prev Med Hyg, V62, pE776, DOI 10.15167/2421-4248/jpmh2021.62.3.1945
   Rahmanian E, 2019, DIABETOL METAB SYNDR, V11, DOI 10.1186/s13098-019-0469-z
   Rosen R, 2000, J SEX MARITAL THER, V26, P191, DOI 10.1080/009262300278597
   Rostami A, 2013, APPL RES QUAL LIFE, V8, P385, DOI 10.1007/s11482-012-9190-x
   Safarinejad MR, 2006, INT J IMPOT RES, V18, P382, DOI 10.1038/sj.ijir.3901440
   Schumm WR, 1996, PSYCHOL REP, V79, P496, DOI 10.2466/pr0.1996.79.2.496
   Schwartz Marlene B, 2004, Body Image, V1, P43, DOI 10.1016/S1740-1445(03)00007-X
   Smith AMA, 2012, INTERN MED J, V42, P641, DOI 10.1111/j.1445-5994.2011.02597.x
   Solymanian A., 1994, DISSERTATION
   van Hout GCM, 2005, OBES SURG, V15, P552, DOI 10.1381/0960892053723484
   Blasco BV, 2020, PSYCHIAT INVEST, V17, P715, DOI 10.30773/pi.2020.0099
   Whisman MA, 1999, J ABNORM PSYCHOL, V108, P674, DOI 10.1037/0021-843X.108.4.674
   Whisman MA, 1999, J ABNORM PSYCHOL, V108, P701, DOI 10.1037/0021-843X.108.4.701
   White MA, 2004, OBES RES, V12, P949, DOI 10.1038/oby.2004.116
   Wiegel M, 2005, J SEX MARITAL THER, V31, P1, DOI 10.1080/00926230590475206
   Wolf AM, 2000, OBES SURG, V10, P445, DOI 10.1381/096089200321593940
   World Health Organization, 2000, World Health Organ Tech Rep Ser, DOI DOI 10.1596/0-1952-1129-4
   Yaylali GF, 2010, INT J IMPOT RES, V22, P220, DOI 10.1038/ijir.2010.7
   Yazdznpanahi Z., 2016, SHIRAZ E MED J, V17, DOI https://doi.org/10.17795/semj38573
NR 69
TC 0
Z9 0
U1 0
U2 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1468-1994
EI 1468-1749
J9 SEX RELATSH THER
JI Sex. Relatsh. Ther.
PD APR 3
PY 2025
VL 40
IS 2
BP 383
EP 395
DI 10.1080/14681994.2025.2456975
EA JAN 2025
PG 13
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA 1SN3E
UT WOS:001417180200001
DA 2025-06-11
ER

PT J
AU Shearrer, GE
   Daniels, MJ
   Toledo-Corral, CM
   Weigensberg, MJ
   Spruijt-Metz, D
   Davis, JN
AF Shearrer, G. E.
   Daniels, M. J.
   Toledo-Corral, C. M.
   Weigensberg, M. J.
   Spruijt-Metz, D.
   Davis, J. N.
TI Associations among sugar sweetened beverage intake, visceral fat, and
   cortisol awakening response in minority youth
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Adolescences; Cortisol awakening response; Visceral adipose tissue;
   Sugar-sweetened beverage
ID SOFT DRINK CONSUMPTION; ADIPOSE-TISSUE; METABOLIC SYNDROME; GLYCEMIC
   INDEX; CARDIOMETABOLIC RISK; INSULIN SENSITIVITY; DIETARY SUGAR;
   UNITED-STATES; ACUTE STRESS; OVERWEIGHT
AB Context: Abdominal adiposity has long been associated with excess caloric intake possibly resulting from increased psychosocial stress and associated cortisol dysfunction. However, the relationship of sugar-sweetened beverage (SSB) intake specifically with cortisol variability and visceral adipose tissue (VAT) is unknown.
   Objective: To examine the relationships between SSB intake, VAT, and cortisol response in minority youth.
   Design: A cross-sectional analysis. Setting: The University of Southern California.
   Participants: 60 overweight/obese Non-Hispanic Black and Hispanic adolescents ages 14-18 years.
   Main outcome measures: VAT via Magnet Resonance Imaging (MRI), cortisol awakening response (CAR) via multiple salivary samples, and SSB intake via multiple 24-hour diet recalls. SSB intake was divided into the following: low SSB consumers (<1 servings per day), medium SSB consumers (>= 1-<2 servings per day), high SSB consumers (>= 2 servings per day). Analysis of covariance were run with VAT and CAR as dependent variables and SSB intake categories (independent variable) with the following a priori covariates: sex, Tanner stage, ethnicity, caloric intake, and body mass index.
   Results: The high SSB intake group exhibited a 7% higher VAT compared to the low SSB intake group (beta = 0.25, CI: (0.03, 0.33), p = 0.02). CAR was associated with VAT (beta= 031, CI: (0.01,0.23), p = 0.02). The high SSB intake group exhibited 22% higher CAR compared to the low SSB intake group (beta = 0.30, CI: (0.02,0.48), p = 0.04).
   Conclusion: This is the first study exploring the relationship between SSB, VAT, and CAR. SSB consumption appears to be independently associated greater abdominal adiposity and higher morning cortisol variability in overweight and obese minority youth. This study highlights potential targets for interventions specifically to reduce SSB intake in a minority youth population. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Shearrer, G. E.; Davis, J. N.] Univ Texas Austin, Dept Nutr, Austin, TX 78712 USA.
   [Daniels, M. J.] Univ Texas Austin, Dept Stat & Data Sci, Austin, TX 78712 USA.
   [Daniels, M. J.] Univ Texas Austin, Dept Integrat Biol, Austin, TX 78712 USA.
   [Toledo-Corral, C. M.] Calif State Univ Los Angeles, Dept Publ Hlth, Los Angeles, CA 90032 USA.
   [Weigensberg, M. J.] Univ Southern Calif, Inst Integrat Hlth, Dept Pediat, Keck Sch Med, Los Angeles, CA 90089 USA.
   [Spruijt-Metz, D.] Univ Southern Calif, Ctr Econ & Social Res, Los Angeles, CA 90089 USA.
C3 University of Texas System; University of Texas Austin; University of
   Texas System; University of Texas Austin; University of Texas System;
   University of Texas Austin; California State University System;
   California State University Los Angeles; Los Angeles County Department
   of Public Health; University of Southern California; University of
   Southern California
RP Shearrer, GE (corresponding author), Univ Texas Austin, Dept Nutr Sci, 100 East 24th St,Norman Hackerman Bldg, Austin, TX 78712 USA.
EM graceshearrer@utexas.edu
RI Toledo-Corral, Claudia/J-5299-2019; Davis, Jaimie/AAU-7800-2021
OI Toledo-Corral, Claudia/0000-0002-1228-9070; Daniels,
   Michael/0000-0002-9856-9486
FU NCMHD [P60MD002254]
FX The authors of this paper report no conflicts of interest. DSM and MJW
   were responsible for research design and oversaw all data collection.
   JND oversaw the dietary data collection. CMT performed quality control
   on all clinical and survey data. GES and MJD analyzed the data and
   preformed statistical analysis. GES, JND, DSM, and MJW were involved in
   the data interpretation. GES, JND, DSM, CMT, MJD, and MJVV provided
   edits for the paper. This study is supported by NCMHD grant P60MD002254
   (MI Goran; M.J. Weigensberg for Project 1).
CR Adam TC, 2007, PHYSIOL BEHAV, V91, P449, DOI 10.1016/j.physbeh.2007.04.011
   Adam TC, 2010, J CLIN ENDOCR METAB, V95, P4729, DOI 10.1210/jc.2010-0322
   Alabousi A, 2011, J MAGN RESON IMAGING, V34, P474, DOI 10.1002/jmri.22603
   Bassett R, 2008, APPETITE, V50, P325, DOI 10.1016/j.appet.2007.08.009
   Born JM, 2010, INT J OBESITY, V34, P172, DOI 10.1038/ijo.2009.221
   Chida Y, 2009, BIOL PSYCHOL, V80, P265, DOI 10.1016/j.biopsycho.2008.10.004
   Clow A, 2010, INT REV NEUROBIOL, V93, P153, DOI 10.1016/S0074-7742(10)93007-9
   Clow A, 2010, NEUROSCI BIOBEHAV R, V35, P97, DOI 10.1016/j.neubiorev.2009.12.011
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Davis JN, 2007, AM J CLIN NUTR, V86, P1331, DOI 10.1093/ajcn/86.5.1331
   Della Torre SB, 2016, J ACAD NUTR DIET, V116, P638, DOI 10.1016/j.jand.2015.05.020
   DellaValle DM, 2005, APPETITE, V44, P187, DOI 10.1016/j.appet.2004.11.003
   DeSantis AS, 2007, J ADOLESCENT HEALTH, V41, P3, DOI 10.1016/j.jadohealth.2007.03.006
   Dodd AH, 2013, J NUTR EDUC BEHAV, V45, P240, DOI 10.1016/j.jneb.2012.11.005
   FRIED SK, 1993, J CLIN INVEST, V92, P2191, DOI 10.1172/JCI116821
   Funtikova AN, 2015, J NUTR, V145, P328, DOI 10.3945/jn.114.205229
   Geer EB, 2016, PITUITARY, V19, P117, DOI 10.1007/s11102-015-0690-1
   Gyllenhammer LE, 2014, OBESITY, V22, P474, DOI 10.1002/oby.20594
   Hairston KG, 2009, DIABETES CARE, V32, P1553, DOI 10.2337/dc09-0336
   Hu HH, 2011, OBES REV, V12, pe504, DOI 10.1111/j.1467-789X.2010.00824.x
   Hu HH, 2010, OBESITY, V18, P841, DOI 10.1038/oby.2009.352
   Johnson RK, 2009, CIRCULATION, V120, P1011, DOI 10.1161/CIRCULATIONAHA.109.192627
   Jonnalagadda SS, 2000, J AM DIET ASSOC, V100, P303, DOI 10.1016/S0002-8223(00)00095-X
   Lee MJ, 2014, BBA-MOL BASIS DIS, V1842, P473, DOI 10.1016/j.bbadis.2013.05.029
   Lemmens SG, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016826
   Ma JT, 2014, J NUTR, V144, P1283, DOI 10.3945/jn.113.188599
   Maersk M, 2012, AM J CLIN NUTR, V95, P283, DOI 10.3945/ajcn.111.022533
   Malik VS, 2010, DIABETES CARE, V33, P2477, DOI 10.2337/dc10-1079
   MARSHALL WA, 1969, ARCH DIS CHILD, V44, P291, DOI 10.1136/adc.44.235.291
   MARSHALL WA, 1970, ARCH DIS CHILD, V45, P13, DOI 10.1136/adc.45.239.13
   Micha R, 2011, BRIT J NUTR, V106, P1552, DOI 10.1017/S0007114511002303
   Micha R, 2011, J AM COLL NUTR, V30, P113, DOI 10.1080/07315724.2011.10719950
   Misra M, 2008, AM J PHYSIOL-ENDOC M, V295, pE385, DOI 10.1152/ajpendo.00052.2008
   Mollard RC, 2014, AM J CLIN NUTR, V99, P804, DOI 10.3945/ajcn.113.079277
   Odegaard AO, 2012, OBESITY, V20, P689, DOI 10.1038/oby.2011.277
   Ogden CL, 2014, JAMA-J AM MED ASSOC, V311, P806, DOI 10.1001/jama.2014.732
   Ormsbee MJ, 2015, APPL PHYSIOL NUTR ME, V40, P37, DOI 10.1139/apnm-2014-0256
   Pollock NK, 2012, J NUTR, V142, P251, DOI 10.3945/jn.111.150219
   Ranjit N, 2010, PEDIATRICS, V126, pE754, DOI 10.1542/peds.2010-1229
   Rasmussen AR, 2015, PEDIATRICS, V135, P86, DOI 10.1542/peds.2014-0793
   Reeder SB, 2011, J MAGN RESON IMAGING, V34, P729, DOI 10.1002/jmri.22580
   Rudenga KJ, 2013, INT J OBESITY, V37, P309, DOI 10.1038/ijo.2012.39
   Rutters F, 2009, OBESITY, V17, P72, DOI 10.1038/oby.2008.493
   Sacheck JM, 2014, PEDIATR EXERC SCI, V26, P159, DOI 10.1123/pes.2013-0067
   Silveira LS, 2013, BMC PEDIATR, V13, DOI 10.1186/1471-2431-13-115
   Singh AS, 2008, OBES REV, V9, P474, DOI 10.1111/j.1467-789X.2008.00475.x
   Stanhope KL, 2009, J CLIN INVEST, V119, P1322, DOI 10.1172/JCI37385
   Stimson RH, 2007, J CLIN ENDOCR METAB, V92, P4480, DOI 10.1210/jc.2007-0692
   Stimson RH, 2014, J CLIN ENDOCR METAB, V99, P160, DOI 10.1210/jc.2013-2307
   Therrien F, 2007, OBESITY, V15, P377, DOI 10.1038/oby.2007.509
   Toledo-Corral CM, 2015, ACTA DIABETOL, V52, P277, DOI 10.1007/s00592-014-0634-7
   Toledo-Corral CM, 2013, PSYCHONEUROENDOCRINO, V38, P1658, DOI 10.1016/j.psyneuen.2013.01.011
   Toledo-Corral CM, 2013, J CLIN ENDOCR METAB, V98, P1115, DOI 10.1210/jc.2012-3806
   Tomiyama AJ, 2011, PSYCHONEUROENDOCRINO, V36, P1513, DOI 10.1016/j.psyneuen.2011.04.005
   Tryon MS, 2013, PHYSIOL BEHAV, V114, P32, DOI 10.1016/j.physbeh.2013.02.018
   Tsai SL, 2013, J CLIN RES PEDIATR E, V5, P85, DOI 10.4274/Jcrpe.892
   Vartanian LR, 2007, AM J PUBLIC HEALTH, V97, P667, DOI 10.2105/AJPH.2005.083782
   Walker RW, 2014, NUTRITION, V30, P928, DOI 10.1016/j.nut.2014.04.003
   Warne JP, 2009, MOL CELL ENDOCRINOL, V300, P137, DOI 10.1016/j.mce.2008.09.036
   Weigensberg MJ, 2008, J CLIN ENDOCR METAB, V93, P1372, DOI 10.1210/jc.2007-2309
   Zellner DA, 2006, PHYSIOL BEHAV, V87, P789, DOI 10.1016/j.physbeh.2006.01.014
   Zheng M, 2014, EUR J CLIN NUTR, V68, P77, DOI 10.1038/ejcn.2013.243
NR 62
TC 20
Z9 24
U1 1
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD DEC 1
PY 2016
VL 167
BP 188
EP 193
DI 10.1016/j.physbeh.2016.09.020
PG 6
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA EC3SX
UT WOS:000388047700022
PM 27660033
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Moreno-Fernández, S
   Garcés-Rimón, M
   González, C
   Uranga, JA
   López-Miranda, V
   Vera, G
   Miguel, M
AF Moreno-Fernandez, S.
   Garces-Rimon, M.
   Gonzalez, C.
   Uranga, J. A.
   Lopez-Miranda, V.
   Vera, G.
   Miguel, M.
TI Pepsin egg white hydrolysate ameliorates metabolic syndrome in
   high-fat/high-dextrose fed rats
SO FOOD & FUNCTION
LA English
DT Article
ID SPONTANEOUSLY HYPERTENSIVE-RATS; LONG-TERM INTAKE; OXIDATIVE STRESS;
   ENZYMATIC-HYDROLYSIS; INSULIN-RESISTANCE; HIGH-FAT; PEPTIDES; DIET;
   OBESITY; PROTEINS
AB The aim of this study was to examine the effect of a pepsin egg white hydrolysate (EWH) on metabolic complications using a high-fat/high-dextrose diet-induced Metabolic Syndrome (MetS) experimental model. Male Wistar rats were divided into 4 groups which received: standard diet and water (C), standard diet and a solution with 1 g kg(-1) day(-1) of EWH (CH), high-fat/high-dextrose diet and water (MS), and high-fat/high-dextrose diet and a solution with 1 g kg(-1) day(-1) of EWH (MSH). EWH consumption normalized body weight gain; abdominal obesity and peripheral neuropathy developed in MetS animals, and adipose tissue and liver weight, as well as plasma glucose were reduced. Oxidative stress and inflammation biomarkers were normalized in MSH animals. In conclusion, the oral administration of EWH could be used as a functional food ingredient to improve some complications associated with MetS induced by unhealthy diets.
C1 [Moreno-Fernandez, S.; Garces-Rimon, M.; Miguel, M.] UAM, CSIC, Inst Invest Ciencias Alimentac CIAL, Madrid, Spain.
   [Moreno-Fernandez, S.; Garces-Rimon, M.; Gonzalez, C.; Uranga, J. A.; Lopez-Miranda, V.; Vera, G.] CSIC, Inst Invest Ciencias Alimentac CIAL, Unidad Asociada I D I, Madrid, Spain.
   [Gonzalez, C.; Uranga, J. A.; Lopez-Miranda, V.; Vera, G.; Miguel, M.] Univ Rey Juan Carlos, Fac Ciencias Salud, Ciencias Basicas Salud, Madrid, Spain.
   [Uranga, J. A.; Lopez-Miranda, V.; Vera, G.] URJC Banco Santander, Grp Excelencia Invest, Grp Multidisciplinar Invest & Tratamiento Dolor I, Alcorcon, Spain.
   [Lopez-Miranda, V.; Vera, G.] CSIC, IQM, Unidad Asociada I D I, Madrid, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-UAM -
   Instituto de Investigacion en Ciencias de la Alimentacion (CIAL);
   Autonomous University of Madrid; Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC-UAM - Instituto de Investigacion en Ciencias de
   la Alimentacion (CIAL); Universidad Rey Juan Carlos; Consejo Superior de
   Investigaciones Cientificas (CSIC); CSIC - Instituto de Quimica Medica
   (IQM)
RP Miguel, M (corresponding author), UAM, CSIC, Inst Invest Ciencias Alimentac CIAL, Madrid, Spain.; Miguel, M (corresponding author), Univ Rey Juan Carlos, Fac Ciencias Salud, Ciencias Basicas Salud, Madrid, Spain.
EM marta.miguel@csic.es
RI Vera, Gema/AAB-1731-2019; Garces-Rimon, Marta/AAD-3050-2021; Uranga,
   Jose/M-4343-2018; Lopez-Miranda, Visitacion/E-1116-2012; MIGUEL CASTRO,
   MARTA/F-6112-2011
OI Uranga, Jose/0000-0003-4656-8569; Lopez-Miranda,
   Visitacion/0000-0003-1378-0387; Moreno-Fernandez,
   Silvia/0000-0002-9316-6477; MIGUEL CASTRO, MARTA/0000-0002-5525-1056;
   Vera Pasamontes, Gema/0000-0002-1838-0975; Garces-Rimon,
   Marta/0000-0002-3888-4150
FU Spanish Ministry of Economy, Industry and Competitiveness (MINECO)
   [AGL2012-32387, BES-2013-065684, 201570I028]
FX Authors would like to acknowledge the financial support of the Spanish
   Ministry of Economy, Industry and Competitiveness (MINECO) (under the
   projects AGL2012-32387 and CSIC - Intramural 201570I028 and under grant
   number BES-2013-065684).
CR Aguilar-Valles A, 2015, NEUROPHARMACOLOGY, V96, P124, DOI 10.1016/j.neuropharm.2014.12.023
   Amerongen A.V., 2009, Patent No. 2009128713
   Andersen CJ, 2013, REV ENDOCR METAB DIS, V14, P241, DOI 10.1007/s11154-013-9251-y
   Avelar T. M. T., 2015, J BRAS PATOL MED LAB, V51, P23
   Babizhayev MA, 2015, CELL BIOCHEM BIOPHYS, V71, P1425, DOI 10.1007/s12013-014-0365-y
   Bonomini F, 2015, AGING DIS, V6, P109, DOI 10.14336/AD.2014.0305
   Carillon J, 2013, FREE RADICAL BIO MED, V65, P254, DOI 10.1016/j.freeradbiomed.2013.06.022
   Dávalos A, 2004, J FOOD PROTECT, V67, P1939, DOI 10.4315/0362-028X-67.9.1939
   Ferrannini E, 1998, J HYPERTENS, V16, P895, DOI 10.1097/00004872-199816070-00001
   Garcés-Rimón M, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0151193
   Garcés-Rimón M, 2016, EUR FOOD RES TECHNOL, V242, P61, DOI 10.1007/s00217-015-2518-7
   Golbidi S, 2014, J DIABETES RES, V2014, DOI 10.1155/2014/726861
   Heinonen I, 2014, ACTA PHYSIOL, V211, P515, DOI 10.1111/apha.12253
   Kamencic H, 2000, ANAL BIOCHEM, V286, P35, DOI 10.1006/abio.2000.4765
   Ko SC, 2013, CURR PROTEIN PEPT SC, V14, P183
   König D, 2012, NUTRITION, V28, P35, DOI 10.1016/j.nut.2011.02.008
   Lupachyk S, 2012, FREE RADICAL BIO MED, V52, P1255, DOI 10.1016/j.freeradbiomed.2012.01.029
   Manso MA, 2008, FOOD CHEM, V109, P361, DOI 10.1016/j.foodchem.2007.12.049
   Miguel M, 2005, BRIT J NUTR, V94, P731, DOI 10.1079/BJN20051570
   Miguel M, 2004, J FOOD PROTECT, V67, P1914, DOI 10.4315/0362-028X-67.9.1914
   Miguel M, 2007, J AGR FOOD CHEM, V55, P10615, DOI 10.1021/jf072307o
   Miguel M, 2007, REGUL PEPTIDES, V140, P131, DOI 10.1016/j.regpep.2006.11.029
   Miguel M, 2006, LIFE SCI, V78, P2960, DOI 10.1016/j.lfs.2005.11.025
   Mobley CB, 2014, NUTR METAB, V11, DOI 10.1186/1743-7075-11-19
   Morris MJ, 2008, INT J OBESITY, V32, P249, DOI 10.1038/sj.ijo.0803716
   Nakamura K, 2014, J CARDIOL, V63, P250, DOI 10.1016/j.jjcc.2013.11.006
   Panchal SK, 2011, J CARDIOVASC PHARM, V57, P51, DOI [10.1097/FJC.0b013e3181feb90a, 10.1097/FJC.0b013e31821b1379]
   Panchal SK, 2011, J BIOMED BIOTECHNOL, DOI 10.1155/2011/351982
   Power O, 2014, P NUTR SOC, V73, P34, DOI 10.1017/S0029665113003601
   Ratliff J, 2010, NUTR RES, V30, P96, DOI 10.1016/j.nutres.2010.01.002
   Ren SY, 2015, BBA-MOL BASIS DIS, V1852, P225, DOI 10.1016/j.bbadis.2014.04.029
   Sanches SCL, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/574832
   Shawky NM, 2014, EUR J PHARMACOL, V740, P353, DOI 10.1016/j.ejphar.2014.07.021
   Singh Z, 2014, IRAN J PUBLIC HEALTH, V43, P7
   Sweazea KL, 2014, ACTA PHYSIOL, V211, P471, DOI 10.1111/apha.12303
   Tominaga Y., 2014, NUTRAfoods, V13, P35
   Tsuchida A, 2004, J BIOL CHEM, V279, P30817, DOI 10.1074/jbc.M402367200
   Udenigwe CC, 2015, INT J MOL SCI, V16, P9303, DOI 10.3390/ijms16059303
   Xie F, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057427
   Yuliana ND, 2014, CRIT REV FOOD SCI, V54, P373, DOI 10.1080/10408398.2011.586739
NR 40
TC 23
Z9 23
U1 2
U2 24
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JAN
PY 2018
VL 9
IS 1
BP 78
EP 86
DI 10.1039/c7fo01280b
PG 9
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA FT7RV
UT WOS:000423351400006
PM 29114652
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Zhu, L
   Yang, L
   Liang, ZH
   Shi, W
   Ma, M
   Chen, JB
   Abdula, Z
   Gong, XC
AF Zhu, Li
   Yang, Long
   Liang, Zonghua
   Shi, Wen
   Ma, Ming
   Chen, Jingbo
   Abdula, Zulipikaer
   Gong, Xuchen
TI Association between dietary calcium intake and constipation in a
   metabolic syndrome population: evidence from NHANES 2005-2010
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE metabolic syndrome; calcium; dietary; constipation; NHANES
ID IRRITABLE-BOWEL-SYNDROME; COLORECTAL-CANCER; REPRESENTATIVE SAMPLE;
   GLOBAL PREVALENCE; NATIONAL-HEALTH; RISK-FACTORS; VITAMIN-D; BODY-FAT;
   ADULTS; COLON
AB Background The global prevalence of Metabolic Syndrome (MetS) is increasing, primarily characterized by abdominal obesity, which significantly heightens the risk of cardiovascular diseases, gastrointestinal disorders, and cancers. Constipation is a common gastrointestinal issue that impacts both physiological and psychological health and worsens with age. Calcium, an essential mineral vital for human health, has been proven to be crucial not only for bone health but also beneficial for gastrointestinal health. However, the results regarding its impact on constipation are inconsistent. This study aimed to investigate the relationship between dietary calcium intake and constipation in individuals with MetS.Methods This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2010. Participants were assessed for MetS based on the International Diabetes Federation (IDF) criteria. Dietary calcium intake was evaluated through 24-h dietary recalls, and constipation was defined based on the frequency of bowel movements recorded in the bowel health questionnaire. The relationship between calcium intake and constipation was explored using logistic regression models with adjustment for covariates, and restricted cubic spline analyses were also used to investigate nonlinear relationships.Results The study included 4,838 adult participants with MetS. Adjusted logistic regression revealed that an increase in dietary calcium intake was significantly associated with a reduced risk of constipation (OR: 0.562, 95% CI: 0.379 to 0.835, p = 0.006). Compared to the lowest quartile, the highest quartile of dietary calcium intake significantly decreased the risk of constipation (OR: 0.282, 95% CI: 0.115 to 0.691, p = 0.008). Results from the restrictive cubic spline analysis indicated a negative linear association between dietary calcium intake and constipation risk (non-linearity p = 0.704).Conclusion The findings suggested that increased dietary calcium intake is associated with a decreased risk of constipation among MetS patients, emphasizing dietary calcium as a potentially modifiable factor for managing gastrointestinal symptoms in this population.
C1 [Zhu, Li; Liang, Zonghua; Shi, Wen; Abdula, Zulipikaer; Gong, Xuchen] Peoples Hosp Xinjiang Uygur Autonomous Reg, Dept Anus & Intestine Surg, Urumqi, Peoples R China.
   [Yang, Long] Xinjiang Med Univ, Affiliated Hosp 1, Pediat Cardiothorac Surg, Urumqi, Peoples R China.
   [Ma, Ming] Peoples Hosp Xinjiang Uygur Autonomous Reg, Res & Educ Ctr, Urumqi, Peoples R China.
   [Chen, Jingbo] Peoples Hosp Xinjiang Uygur Autonomous Reg, Dept Tradit Chinese Med, Urumqi, Peoples R China.
C3 Xinjiang Medical University
RP Zhu, L (corresponding author), Peoples Hosp Xinjiang Uygur Autonomous Reg, Dept Anus & Intestine Surg, Urumqi, Peoples R China.
EM 158096894@qq.com
RI Yang, Long/GWC-6053-2022
OI Yang, Long/0000-0003-1870-878X
FU Xinjiang Uygur Autonomous Region's Natural Science Foundation
   [2022D01C142]; Xinjiang Uygur Autonomous Region Graduate Student
   Innovation Program [XJ2024G167]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This research
   was supported by the Xinjiang Uygur Autonomous Region's Natural Science
   Foundation (2022D01C142) and the Xinjiang Uygur Autonomous Region
   Graduate Student Innovation Program (XJ2024G167).
CR Ahluwalia N, 2016, ADV NUTR, V7, P121, DOI 10.3945/an.115.009258
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alyousif Z, 2016, CAN J DIET PRACT RES, V77, P103, DOI 10.3148/cjdpr-2015-043
   Andy UU, 2016, J AM GERIATR SOC, V64, pE183, DOI 10.1111/jgs.14521
   Barberio B, 2021, LANCET GASTROENTEROL, V6, P638, DOI 10.1016/S2468-1253(21)00111-4
   Beggs MR, 2022, J STEROID BIOCHEM, V220, DOI 10.1016/j.jsbmb.2022.106098
   Bernstein C, 2011, ARCH TOXICOL, V85, P863, DOI 10.1007/s00204-011-0648-7
   Bredariol ANM, 2020, CLIN NUTR ESPEN, V39, P206, DOI 10.1016/j.clnesp.2020.06.012
   Chen HY, 2021, GUT, V70, P1147, DOI 10.1136/gutjnl-2020-321661
   Cornier MA, 2008, ENDOCR REV, V29, P777, DOI 10.1210/er.2008-0024
   Costa LM, 2022, EUR J NUTR, V61, P341, DOI 10.1007/s00394-021-02649-2
   Curtin Lester R, 2012, Vital Health Stat 2, P1
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Dwyer J, 2001, J AM DIET ASSOC, V101, P1142, DOI 10.1016/S0002-8223(01)00279-6
   Eilat-Adar S, 2007, J NUTR, V137, P1955, DOI 10.1093/jn/137.8.1955
   Fedirko V, 2009, CANCER EPIDEM BIOMAR, V18, P2933, DOI 10.1158/1055-9965.EPI-09-0239
   Forootan M, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000010631
   Fu SF, 2022, NEUROGASTROENT MOTIL, V34, DOI 10.1111/nmo.14234
   Giovannucci E, 2007, AM J CLIN NUTR, V86, p836S, DOI 10.1093/ajcn/86.3.836S
   Gupta A, 2010, BIOSCI TRENDS, V4, P204
   Hopkins MH, 2011, CANCER PREV RES, V4, P1645, DOI 10.1158/1940-6207.CAPR-11-0105
   Hsu CN, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222111872
   Huang LN, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027703
   Inker LA, 2012, NEW ENGL J MED, V367, P20, DOI 10.1056/NEJMoa1114248
   Johnson Clifford L, 2014, Vital Health Stat 2, P1
   Kirchhoff P, 2006, WORLD J GASTROENTERO, V12, P3229, DOI 10.3748/wjg.v12.i20.3229
   Kunzelmann K, 2002, PHYSIOL REV, V82, P245, DOI 10.1152/physrev.00026.2001
   Lacy BE, 2016, GASTROENTEROLOGY, V150, P1393, DOI 10.1053/j.gastro.2016.02.031
   Le Pluart D, 2015, ALIMENT PHARM THER, V41, P758, DOI 10.1111/apt.13143
   Lewis JR, 2012, J BONE MINER RES, V27, P719, DOI 10.1002/jbmr.1484
   Liu B, 2023, ARTHRITIS RES THER, V25, DOI 10.1186/s13075-023-03018-6
   Lovell RM, 2012, CLIN GASTROENTEROL H, V10, P712, DOI 10.1016/j.cgh.2012.02.029
   Markland AD, 2013, AM J GASTROENTEROL, V108, P796, DOI 10.1038/ajg.2013.73
   Mearin F, 2005, GASTROENTEROLOGY, V129, P98, DOI 10.1053/j.gastro.2005.04.012
   Miron I, 2019, ACTA ENDOCRINOL-BUCH, V15, P497, DOI 10.4183/aeb.2019.497
   Mitsuhashi S, 2018, AM J GASTROENTEROL, V113, P115, DOI 10.1038/ajg.2017.213
   Mujagic Z, 2014, ALIMENT PHARM THER, V40, P288, DOI 10.1111/apt.12829
   Muzurovic E, 2021, METABOLISM, V119, DOI 10.1016/j.metabol.2021.154770
   Owczarek D, 2016, WORLD J GASTROENTERO, V22, P895, DOI 10.3748/wjg.v22.i3.895
   Pollak M, 2008, NAT REV CANCER, V8, P915, DOI 10.1038/nrc2536
   Quail DF, 2019, NAT REV ENDOCRINOL, V15, P139, DOI 10.1038/s41574-018-0126-x
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Singh P, 2018, AM J GASTROENTEROL, V113, P593, DOI 10.1038/ajg.2018.24
   Song MY, 2015, GASTROENTEROLOGY, V148, P1244, DOI 10.1053/j.gastro.2014.12.035
   Sundboll J, 2019, CLIN EPIDEMIOL, V11, P299, DOI 10.2147/CLEP.S205957
   Tashiro N, 2011, ASIAN PAC J CANCER P, V12, P2025
   Torres MJ, 2018, THER ADV GASTROENTER, V11, P1, DOI 10.1177/1756283X17746625
   Vilar-Gomez E, 2022, HEPATOLOGY, V75, P1491, DOI 10.1002/hep.32207
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Waclawikova B, 2021, PLOS BIOL, V19, DOI 10.1371/journal.pbio.3001070
   Wan YM, 2021, AGING-US, V13, P6702, DOI 10.18632/aging.202526
   Wang PF, 2023, FRONT PSYCHIATRY, V14, DOI 10.3389/fpsyt.2023.1152435
   Wang W, 2019, MOL CANCER RES, V17, P2145, DOI 10.1158/1541-7786.MCR-19-0429
   Watling CZ, 2023, BRIT J CANCER, V129, P636, DOI 10.1038/s41416-023-02339-2
   Wilder-Smith CH, 2011, GUT, V60, P1589, DOI 10.1136/gutjnl-2011-300253
   Xiang NJ, 2024, BMC PUBLIC HEALTH, V24, DOI 10.1186/s12889-024-18647-y
   Yang WS, 2019, CLIN CANCER RES, V25, P1980, DOI 10.1158/1078-0432.CCR-18-2965
   Zhou E, 2021, GASTROENTEROL CLIN N, V50, P101, DOI 10.1016/j.gtc.2020.10.012
   Zipf George, 2013, Vital Health Stat 1, P1
NR 59
TC 0
Z9 0
U1 3
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD OCT 30
PY 2024
VL 11
AR 1422564
DI 10.3389/fnut.2024.1422564
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA L7Y0O
UT WOS:001352830000001
PM 39539369
OA gold
DA 2025-06-11
ER

PT J
AU Kim, S
   Lee, AY
   Kim, HJ
   Hong, SH
   Go, RE
   Choi, KC
   Kang, KS
   Cho, MH
AF Kim, Sanghwa
   Lee, Ah Young
   Kim, Hyeon-Jeong
   Hong, Seong-Ho
   Go, Ryeo-Eun
   Choi, Kyung-Chul
   Kang, Kyung-Sun
   Cho, Myung-Haing
TI Exposure to cigarette smoke disturbs adipokines secretion causing
   intercellular damage and insulin resistance in high fructose diet
   induced metabolic disorder mice
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Cigarette smoke; High fructose diet; Organelle damage; ER stress;
   Adipokines; Insulin resistance
ID ENDOPLASMIC-RETICULUM STRESS; BODY-WEIGHT; ER STRESS; LEPTIN LEVELS;
   PLASMA; CESSATION; OBESITY; INFLAMMATION; ADIPONECTIN; GHRELIN
AB A large amount of fructose intake along with smoking is associated with increased incidence of diseases linked to metabolic syndrome. More research is necessary to understand the complex mechanism that ultimately results in metabolic syndrome and the effect, if any, of high fructose dietary intake and smoking on individual health. In this study, we investigated changes in ER-Golgi network and disturbance to secretion of adipokines induced by cigarette smoking (CS) and excess fructose intake and their contribution to the disruption of metabolic homeostasis. We used high fructose-induced metabolic disorder mice model by feeding them with high fructose diet for 8 weeks. For CS exposure experiment, these mice were exposed to CS for 28 days according to OECD guideline 412. Our results clearly showed that the immune system was suppressed and ER stress was induced in mice with exposure to CS and fed with high fructose. Furthermore, their concentrations of adipokines including leptin and adiponectin were aberrant. Such alteration in secretion of adipokines could cause insulin resistance which may lead to the development of type 2 diabetes. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Kim, Sanghwa] Korea Inst Radiol & Med Sci, Div Basic Radiat Biosci, Seoul 01812, South Korea.
   [Kim, Sanghwa; Lee, Ah Young; Kim, Hyeon-Jeong; Hong, Seong-Ho; Cho, Myung-Haing] Seoul Natl Univ, Coll Vet Med, Lab Toxicol, Seoul 08826, South Korea.
   [Hong, Seong-Ho] CKD Res Inst, Bio Med Lab, Yongin 16995, South Korea.
   [Go, Ryeo-Eun; Choi, Kyung-Chul] Chungbuk Natl Univ, Vet Med Ctr, Lab Biochem & Immunol, Cheongju 28644, Chungbuk, South Korea.
   [Go, Ryeo-Eun; Choi, Kyung-Chul] Chungbuk Natl Univ, Coll Vet Med, Cheongju 28644, Chungbuk, South Korea.
   [Kang, Kyung-Sun] Seoul Natl Univ, Coll Vet Med, Adult Stem Cell Res Ctr, Seoul 08826, South Korea.
   [Cho, Myung-Haing] Seoul Natl Univ, Grad Grp Tumor Biol, Seoul 08826, South Korea.
   [Cho, Myung-Haing] Seoul Natl Univ, Inst GreenBio Sci Technol, Pyeongchang 25354, South Korea.
   [Cho, Myung-Haing] Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Suwon 16229, South Korea.
   [Cho, Myung-Haing] Seoul Natl Univ, Adv Inst Convergence Technol, Suwon 16229, South Korea.
C3 Korea Institute of Radiological & Medical Sciences; Seoul National
   University (SNU); Chungbuk National University; Chungbuk National
   University; Seoul National University (SNU); Seoul National University
   (SNU); Seoul National University (SNU); Seoul National University (SNU);
   Seoul National University (SNU)
RP Cho, MH (corresponding author), Seoul Natl Univ, Coll Vet Med, Lab Toxicol, Seoul 08826, South Korea.
EM mchotox@snu.ac.kr
RI Kang, Kyung-Sun/G-6205-2013; Choi, Kyung-Chul/AHC-2282-2022; Cho,
   Myung-Haing/B-7362-2014
OI Kang, Kyung-Sun/0000-0002-9322-741X; Cho,
   Myung-Haing/0000-0002-3993-2011
FU Ministry of Food and Drug Safety [14182MFDS977]
FX This research was supported by a grant(14182MFDS977) from the Ministry
   of Food and Drug Safety in 2017.
CR Athyros VG, 2013, CURR MED RES OPIN, V29, P1263, DOI 10.1185/03007995.2013.827566
   Borst SE, 2004, ENDOCRINE, V23, P177, DOI 10.1385/ENDO:23:2-3:177
   Broekhuizen R, 2005, RESP MED, V99, P70, DOI 10.1016/j.rmed.2004.03.029
   Cheung O, 2008, SEMIN LIVER DIS, V28, P351, DOI 10.1055/s-0028-1091979
   Chiolero A, 2008, AM J CLIN NUTR, V87, P801, DOI 10.1093/ajcn/87.4.801
   Cnop M, 2012, TRENDS MOL MED, V18, P59, DOI 10.1016/j.molmed.2011.07.010
   Eliasson B, 1999, EUR J CLIN INVEST, V29, P145, DOI 10.1046/j.1365-2362.1999.00420.x
   FACCHINI FS, 1992, LANCET, V339, P1128, DOI 10.1016/0140-6736(92)90730-Q
   Hosoi T, 2008, MOL PHARMACOL, V74, P1610, DOI 10.1124/mol.108.050070
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Hummasti S, 2010, CIRC RES, V107, P579, DOI 10.1161/CIRCRESAHA.110.225698
   Islam MA, 2016, BIOMATERIALS, V102, P43, DOI 10.1016/j.biomaterials.2016.06.013
   Kolovou G.D., 2016, Clin. Lipidol., V11, P6
   Kong C, 2001, ATHEROSCLEROSIS, V156, P373, DOI 10.1016/S0021-9150(00)00664-X
   Kryfti M, 2015, TOB INDUC DIS, V13, DOI 10.1186/s12971-015-0054-7
   Lago R, 2008, CELL IMMUNOL, V252, P139, DOI 10.1016/j.cellimm.2007.09.004
   Lanaspa MA, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3434
   MCCANCE DR, 1994, BRIT MED J, V308, P1323, DOI 10.1136/bmj.308.6940.1323
   Oh SW, 2005, DIABETES CARE, V28, P2064, DOI 10.2337/diacare.28.8.2064
   Olefsky JM, 2010, ANNU REV PHYSIOL, V72, P219, DOI 10.1146/annurev-physiol-021909-135846
   Oron-Herman M, 2008, AM J HYPERTENS, V21, P1018, DOI 10.1038/ajh.2008.218
   Ota T, 2008, J CLIN INVEST, V118, P316, DOI 10.1172/JCI32752
   Ozcan L, 2012, ANNU REV MED, V63, P317, DOI 10.1146/annurev-med-043010-144749
   Rabe K, 2008, MOL MED, V14, P741, DOI 10.2119/2008-00058.Rabe
   Reseland JE, 2005, PROSTAG LEUKOTR ESS, V73, P43, DOI 10.1016/j.plefa.2005.04.006
   Schneeberger M, 2013, CELL, V155, P172, DOI 10.1016/j.cell.2013.09.003
   Seneff S, 2011, ARCH MED SCI, V7, P8, DOI 10.5114/aoms.2011.20598
   Sopori M, 2002, NAT REV IMMUNOL, V2, P372, DOI 10.1038/nri803
   Tomoda K, 2012, J TOXICOL SCI, V37, P131, DOI 10.2131/jts.37.131
   Xie LL, 2008, BBA-MOL BASIS DIS, V1782, P99, DOI 10.1016/j.bbadis.2007.12.003
   Xu L, 2010, HORM METAB RES, V42, P643, DOI 10.1055/s-0030-1255034
   Ypsilantis P, 2013, NICOTINE TOB RES, V15, P206, DOI 10.1093/ntr/nts113
   Yu KN, 2016, NICOTINE TOB RES, V18, P1877, DOI 10.1093/ntr/ntw079
   Zhang W, 2013, GENE DEV, V27, P441, DOI 10.1101/gad.201731.112
   Zong CL, 2015, LIPIDS HEALTH DIS, V14, DOI 10.1186/s12944-015-0160-9
NR 35
TC 5
Z9 5
U1 0
U2 5
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD DEC 16
PY 2017
VL 494
IS 3-4
BP 648
EP 655
DI 10.1016/j.bbrc.2017.10.121
PG 8
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA FN9WJ
UT WOS:000416393300032
PM 29079192
DA 2025-06-11
ER

PT J
AU Bekyarova, GY
   Bekyarov, NA
   Madjova, VH
   Madjova, CR
   Kalevska, ED
   Salim, AS
   Vankova, DG
   Ivanova, DG
   Kiselova-Kaneva, YD
AF Bekyarova, Ganka Y.
   Bekyarov, Nicolai A.
   Madjova, Valentina H.
   Madjova, Christiana R.
   Kalevska, Evgenia D.
   Salim, Ayshe S.
   Vankova, Deyana G.
   Ivanova, Diana G.
   Kiselova-Kaneva, Yoana D.
TI Age-Associated Changes in Carotid Intima-Media Thickness in Relation to
   Redox Balance Indices in Metabolic Syndrome
SO APPLIED SCIENCES-BASEL
LA English
DT Article
DE biomarkers; metabolic syndrome; carotid intima-media thickness;
   peripheral blood mononuclear cells (PBMCs); gene expression
ID ASYMMETRIC DIMETHYLARGININE ADMA; ENDOTHELIAL DYSFUNCTION; OXIDATIVE
   STRESS; HEME OXYGENASE; ATHEROSCLEROSIS; PREDICTOR; IMPACT; ADULTS;
   CELLS; NRF2
AB Featured Application In this study, we evaluated the relationship among the carotid intima-media thickness (CIMT), the redox balance parameters of plasma asymmetric dimethylarginine (ADMA), malondialdehyde (MDA), and HO-1, and the expression of oxidative stress-related NF-kB, Nrf2, and HO-1 in peripheral blood mononuclear cells as biomarkers in metabolic syndrome (MetS). Abstract Metabolic syndrome (MetS) is defined by the World Health Organisation (WHO) as a pathologic condition characterized by abdominal obesity, insulin resistance, hypertension, and hyperlipidaemia. The components of MetS and the associated cardiovascular risks may disrupt the vascular endothelial function and the structure of the vascular wall, increasing the risk of atherosclerosis and vascular diseases. In this study we evaluated the relationship between the carotid intima-media thickness (CIMT), the redox balance parameters of plasma asymmetric dimethylarginine (ADMA), malondialdehyde (MDA), and heme oxygenase 1 (HO-1), and the expression of oxidative stress-related nuclear factor kappa B (NF-kB), nuclear factor erythroid 2-related factor 2 (Nrf2), and HO-1 in peripheral blood mononuclear cells (PBMCs) in MetS. Significantly higher CIMT was established in MetS patients aged >= 55 years as compared with the control group (0.96 +/- 0.29 vs. 0.74 +/- 0.21, p < 0.05). Expression was higher in MetS patients aged < 55 years (83% for NF-kB, p < 0.05; 251% for Nrf2, p < 0.05, and 337% for HO-1, p < 0.05) in comparison to the control group. Similarly, expression was higher in CIMT < 0.90 mm than the control group by 80% for NF-kB, p < 0.01; 260% for Nrf2, p < 0.05, and 303% for HO-1, p < 0.05. In contrast, gene expression was under-regulated in the subgroups of MetS patients aged >= 55 years and MetS patients with CIMT >= 0.90 mm. Significantly higher plasma levels for MDA, ADMA, and HO-1 were established in the age < 55 and age >= 55 MetS subgroups and the CIMT < 0.90 mm and CIMT >= 0.90 mm subgroups. In conclusion, MetS individuals aged >= 55 are at higher risk of increased CIMT and impaired redox balance.
C1 [Bekyarova, Ganka Y.] Med Univ Varna, Dept Physiol & Pathophysiol, Varna 9002, Bulgaria.
   [Bekyarov, Nicolai A.; Madjova, Valentina H.] Med Univ Varna, Dept Gen Med, Varna 9002, Bulgaria.
   [Madjova, Christiana R.] Med Univ Varna, Dept Conservat Dent Treatment & Oral Pathol, Varna 9002, Bulgaria.
   [Kalevska, Evgenia D.] Med Univ Varna, Dept Neurol & Neurosci, Varna 9002, Bulgaria.
   [Salim, Ayshe S.; Vankova, Deyana G.; Ivanova, Diana G.; Kiselova-Kaneva, Yoana D.] Med Univ Varna, Dept Biochem Mol Med & Nutrigen, Varna 9002, Bulgaria.
C3 Medical University Varna; Medical University Varna; Medical University
   Varna; Medical University Varna; Medical University Varna
RP Kiselova-Kaneva, YD (corresponding author), Med Univ Varna, Dept Biochem Mol Med & Nutrigen, Varna 9002, Bulgaria.
EM ganka.bekyarova@abv.bg; ninobek@abv.bg; valentina.madjova@mu-varna.bg;
   christiana.madjova@mu-varna.bg; kalevska@abv.bg;
   ayshe.salim@mu-varna.bg; deyana.vankova@mu-varna.bg;
   divanova@mu-varna.bg; yoana.kiselova@mu-varna.bg
RI Vankova, Deyana/MZQ-2229-2025; Ivanova, Diana/JVY-8696-2024
FU Union-NextGenerationEU through the National Recovery and Resilience Plan
   of the Republic of Bulgaria [BG-RRP-2.004-0009-C02]; European
   Union-NextGenerationEU through the National Recovery and Resilience Plan
   of the Republic of Bulgaria
FX This study is financed by the European Union-NextGenerationEU through
   the National Recovery and Resilience Plan of the Republic of Bulgaria,
   project No. BG-RRP-2.004-0009-C02, Research group 3.1.1. Natura4Health.
CR Abraham NG, 2008, PHARMACOL REV, V60, P79, DOI 10.1124/pr.107.07104
   Abraham NG, 2005, FREE RADICAL BIO MED, V39, P1, DOI 10.1016/j.freeradbiomed.2005.03.010
   Aydin M, 2013, EUR REV MED PHARMACO, V17, P2295
   Böger RH, 2003, CLIN CHEM LAB MED, V41, P1467, DOI 10.1515/CCLM.2003.225
   Bouras G, 2013, CURR TOP MED CHEM, V13, P180, DOI 10.2174/1568026611313020007
   Chen B, 2015, J ENDOCRINOL, V225, pR83, DOI 10.1530/JOE-14-0662
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Dawson JD, 2009, J AM COLL CARDIOL, V53, P2273, DOI 10.1016/j.jacc.2009.03.026
   Ferrándiz ML, 2008, CURR PHARM DESIGN, V14, P473, DOI 10.2174/138161208783597399
   Rubio-Guerra AF, 2010, CLIN EXP HYPERTENS, V32, P308, DOI 10.3109/10641960903443533
   Furuki K, 2008, HYPERTENS RES, V31, P1185, DOI 10.1291/hypres.31.1185
   He MH, 2015, FREE RADICAL BIO MED, V89, P91, DOI 10.1016/j.freeradbiomed.2015.07.151
   Idriss NK, 2010, THROMB HAEMOSTASIS, V104, P1029, DOI 10.1160/TH09-11-0802
   Jia GH, 2019, BBA-MOL BASIS DIS, V1865, P1802, DOI 10.1016/j.bbadis.2018.08.008
   Jung JM, 2014, J ATHEROSCLER THROMB, V21, P435, DOI 10.5551/jat.18655
   Kawada T, 2016, HEART VESSELS, V31, P664, DOI 10.1007/s00380-015-0668-y
   Kim YM, 2011, ANTIOXID REDOX SIGN, V14, P137, DOI 10.1089/ars.2010.3153
   Kishimoto Y, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20153628
   Koç AS, 2019, TURK KARDIYOL DERN A, V47, P301, DOI 10.5543/tkda.2018.94770
   Kotsis VT, 2006, OBESITY, V14, P1708, DOI 10.1038/oby.2006.196
   Kushida T, 2002, J CELL BIOCHEM, V87, P377, DOI 10.1002/jcb.10316
   Lee JM, 2005, FASEB J, V19, P1061, DOI 10.1096/fj.04-2591hyp
   Luna-Ceron E, 2022, CURR VASC PHARMACOL, V20, P205, DOI 10.2174/1570161120666220510120220
   Lundman P, 2001, J AM COLL CARDIOL, V38, P111, DOI 10.1016/S0735-1097(01)01318-3
   Mangoni AA, 2021, CURR PHARM DESIGN, V27, P2131, DOI 10.2174/1381612827666210106144247
   Mathieu P, 2006, VASC HEALTH RISK MAN, V2, P285, DOI 10.2147/vhrm.2006.2.3.285
   Motohashi H, 2004, TRENDS MOL MED, V10, P549, DOI 10.1016/j.molmed.2004.09.003
   Nair N, 2017, CURR CARDIOL REV, V13, P183, DOI 10.2174/1573403X13666170216150955
   Nezu T, 2016, J ATHEROSCLER THROMB, V23, P18, DOI 10.5551/jat.31989
   Novo S, 2010, EUR J CARDIOV PREV R, V17, P514, DOI 10.1097/HJR.0b013e328337ccbd
   Pae HO, 2010, NITRIC OXIDE-BIOL CH, V23, P251, DOI 10.1016/j.niox.2010.08.002
   Peterson SJ, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20102514
   Pezzano A, 2006, J CARDIOVASC MED, V7, P555, DOI 10.2459/01.JCM.0000234774.81077.a6
   Poredos P, 2006, INT ANGIOL, V25, P280
   PORTER NA, 1976, BIOCHIM BIOPHYS ACTA, V441, P506, DOI 10.1016/0005-2760(76)90247-2
   Robertson CM, 2012, VASC MED, V17, P239, DOI 10.1177/1358863X12445103
   Said MA, 2022, ARCH PHYSIOL BIOCHEM, V128, P959, DOI 10.1080/13813455.2020.1741645
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Scuteri A, 2004, J AM COLL CARDIOL, V43, P1388, DOI 10.1016/j.jacc.2003.10.061
   Tziomalos K, 2010, NUTR METAB CARDIOVAS, V20, P140, DOI 10.1016/j.numecd.2009.08.006
   Ungvari Z, 2011, AM J PHYSIOL-HEART C, V300, pH1133, DOI 10.1152/ajpheart.00402.2010
   Wu SS, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/6859757
   Zhang J, 2022, REV CARDIOVASC MED, V23, DOI 10.31083/j.rcm2302073
   Zhang Q, 2021, J ADV RES, V34, P43, DOI 10.1016/j.jare.2021.06.023
   Zoccali C, 2002, J AM SOC NEPHROL, V13, P490, DOI 10.1681/ASN.V132490
NR 45
TC 0
Z9 0
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3417
J9 APPL SCI-BASEL
JI Appl. Sci.-Basel
PD AUG
PY 2024
VL 14
IS 16
AR 7218
DI 10.3390/app14167218
PG 12
WC Chemistry, Multidisciplinary; Engineering, Multidisciplinary; Materials
   Science, Multidisciplinary; Physics, Applied
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering; Materials Science; Physics
GA F1H8Q
UT WOS:001307407800001
OA gold
DA 2025-06-11
ER

PT J
AU Medina, SP
   Kim, RG
   Magee, C
   Stapper, N
   Khalili, M
AF Medina, Sheyla P.
   Kim, Rebecca G.
   Magee, Catherine
   Stapper, Noah
   Khalili, Mandana
TI Cross-sectional study on stigma and motivation to adhere to lifestyle
   modification among vulnerable populations with fatty liver disease
SO OBESITY SCIENCE & PRACTICE
LA English
DT Article
DE alcohol-associated liver disease; behavioral modification; metabolic
   syndrome; NAFLD; underserved populations
ID UNITED-STATES; NONALCOHOLIC STEATOHEPATITIS; WEIGHT-LOSS; HEPATIC
   STEATOSIS; HEALTH; DISPARITIES; PREVALENCE; IMPACT; ADULTS; OVERWEIGHT
AB ObjectivesAdherence to lifestyle modification (diet, exercise, and alcohol cessation) for fatty liver disease (FLD) management remains challenging. The study examined stigma, barriers, and factors associated with motivation to adhere to lifestyle modification in a diverse and vulnerable population with FLD. MethodsFrom 2/19/2020 to 2/28/2022, 249 FLD patients within San Francisco safety-net hepatology clinics were surveyed along with clinical data taken from medical records. Multivariable modeling assessed factors associated with motivation to adhere to lifestyle modification in a cross-sectional study. ResultsMedian age was 53 years, 59% female, 59% Hispanic, 25% Asian/Pacific Islander, 9% White, and 2% Black, 79% were non-English speakers, 64% had & LE; high school education, and 82% reported <$30,000 annual income. Common comorbidities included hyperlipidemia (47%), hypertension (42%), diabetes (39%), and heavy alcohol use (22%). Majority (78%) reported experiencing stigma, 41% reported extreme motivation, and 58% reported & GE; two barriers. When controlling for age, sex, Hispanic ethnicity, alcohol consumption, BMI, >high school (coef 1.41, 95% CI 0.34-2.48), stigma (coef 0.34, 95% CI 0.07-0.62), and depression (coef -1.52, 95% CI -2.79 to -0.26) were associated with motivation. ConclusionsStigma is commonly reported among FLD patients. Interventions to enhance patient education and mental health support are critical to FLD management, especially in vulnerable populations.
C1 [Medina, Sheyla P.; Kim, Rebecca G.; Khalili, Mandana] Univ Calif San Francisco, Dept Med, Div Gastroenterol & Hepatol, San Francisco, CA USA.
   [Magee, Catherine; Stapper, Noah; Khalili, Mandana] Zuckerberg San Francisco Gen, Div Gastroenterol & Hepatol, San Francisco, CA USA.
   [Khalili, Mandana] Univ Calif San Francisco, San Francisco Gen Hosp, San Francisco, CA 94110 USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   San Francisco General Hospital Medical Center
RP Khalili, M (corresponding author), Univ Calif San Francisco, San Francisco Gen Hosp, San Francisco, CA 94110 USA.
EM mandana.khalili@ucsf.edu
OI khalili, mandana/0000-0001-9178-9139; , Rebecca/0000-0001-7965-5760;
   Medina, Sheyla Paola/0000-0002-3095-0379
FU Zuckerberg San Francisco General Hospital Foundation Hearts Grant;
   National Institutes of Health [K24AA022523, T32DK060414, U24MD017250];
   National Institute of Diabetes and Digestive and Kidney Diseases
   [T32DK060414] Funding Source: NIH RePORTER; National Institute on
   Alcohol Abuse and Alcoholism [K24AA022523] Funding Source: NIH RePORTER;
   National Institute on Minority Health and Health Disparities
   [U24MD017250] Funding Source: NIH RePORTER
FX Zuckerberg San Francisco General Hospital Foundation Hearts Grant;
   National Institutes of Health, Grant/Award Numbers: K24AA022523,
   T32DK060414, U24MD017250
CR Alvidrez J, 2019, AM J PUBLIC HEALTH, V109, pS16, DOI [10.2105/ajph.2018.304883, 10.2105/AJPH.2018.304883]
   [Anonymous], NATL I ALCOHOL ABUSE
   Arora C, 2021, DIABETES METAB SYND, V15, DOI 10.1016/j.dsx.2021.05.011
   Bastani R, 2010, PREV MED, V50, P63, DOI 10.1016/j.ypmed.2009.08.010
   Browne JL, 2013, BMJ OPEN, V3, DOI 10.1136/bmjopen-2013-003384
   Browning JD, 2004, HEPATOLOGY, V40, P1387, DOI 10.1002/hep.20466
   Carol M, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0265153
   Carrieri P, 2022, J HEPATOL, V77, P1221, DOI 10.1016/j.jhep.2022.06.005
   Centis E, 2013, J HEPATOL, V58, P771, DOI 10.1016/j.jhep.2012.11.031
   Chavez-Tapia Norberto C, 2010, Cochrane Database Syst Rev, pCD007340, DOI 10.1002/14651858.CD007340.pub2
   Cho IY, 2021, EPIDEMIOL PSYCH SCI, V30, DOI 10.1017/S204579602000116X
   Crabb DW, 2020, HEPATOLOGY, V71, P306, DOI 10.1002/hep.30866
   Gazmararian JA, 1999, JAMA-J AM MED ASSOC, V281, P545, DOI 10.1001/jama.281.6.545
   Glass L., 2021, DIS KNOWLEDGE HLTH R
   Glass LM, 2015, DIGEST DIS SCI, V60, P1024, DOI 10.1007/s10620-014-3380-3
   Golabi P, 2018, MEDICINE, V97, DOI [10.1097/MD.0000000000010214, 10.1097/md.0000000000010214]
   Grant BF, 2017, JAMA PSYCHIAT, V74, P911, DOI 10.1001/jamapsychiatry.2017.2161
   Haigh L, 2019, CLIN GASTROENTEROL H, V17, P1364, DOI 10.1016/j.cgh.2018.10.044
   Harrison SA, 2009, HEPATOLOGY, V49, P80, DOI 10.1002/hep.22575
   Huang MA, 2005, AM J GASTROENTEROL, V100, P1072, DOI 10.1111/j.1572-0241.2005.41334.x
   Kardashian A, 2023, HEPATOLOGY, V77, P1382, DOI 10.1002/hep.32743
   Khan A, 2016, CLIN GASTROENTEROL H, V14, P191, DOI 10.1016/j.cgh.2015.07.047
   Kim RG, 2022, HEPATOL COMMUN, V6, P1045, DOI 10.1002/hep4.1873
   Lassailly G, 2020, GASTROENTEROLOGY, V159, P1290, DOI 10.1053/j.gastro.2020.06.006
   Lazarus JV, 2021, LIVER INT, V41, P2295, DOI 10.1111/liv.14969
   Lazo M, 2010, DIABETES CARE, V33, P2156, DOI 10.2337/dc10-0856
   Lombardi R, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD011640.pub2
   Mathurin P, 2009, GASTROENTEROLOGY, V137, P532, DOI 10.1053/j.gastro.2009.04.052
   McHugh RK, 2019, ALCOHOL RES-CURR REV, V40, P3, DOI 10.35946/arcr.v40.1.01
   Meyer J, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17186469
   Moon AM, 2020, CLIN GASTROENTEROL H, V18, P2650, DOI 10.1016/j.cgh.2019.07.060
   National Institute on Alcohol Abuse and Alcoholism, RETH DRINK ALC YOUR
   Ng CH, 2023, HEPATOLOGY, V77, P1712, DOI 10.1097/HEP.0000000000000043
   O'Gorman P, 2021, PHYS THER, V101, DOI 10.1093/ptj/pzaa195
   Partida D, 2022, OPEN FORUM INFECT DI, V9, DOI 10.1093/ofid/ofac103
   Peng LJ, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003619.pub3
   Probst C, 2015, SUBST ABUSE TREAT PR, V10, DOI 10.1186/s13011-015-0028-z
   Prochaska JO, 1997, AM J HEALTH PROMOT, V12, P38, DOI 10.4278/0890-1171-12.1.38
   Promrat K, 2010, HEPATOLOGY, V51, P121, DOI 10.1002/hep.23276
   Puhl R, 2015, CURR OBES REP, V4, P182, DOI 10.1007/s13679-015-0153-z
   Rich NE, 2018, CLIN GASTROENTEROL H, V16, P198, DOI 10.1016/j.cgh.2017.09.041
   Rikard RV, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-3621-9
   Rinella ME, 2023, HEPATOLOGY, V77, P1797, DOI 10.1097/HEP.0000000000000323
   Saab S, 2016, CLIN GASTROENTEROL H, V14, P5, DOI 10.1016/j.cgh.2015.05.001
   Sattler Elisabeth Lilian Pia, 2014, Journal of Nutrition in Gerontology and Geriatrics, V33, P401, DOI 10.1080/21551197.2014.959680
   Scambler G, 2009, SOCIOL HEALTH ILL, V31, P441, DOI 10.1111/j.1467-9566.2009.01161.x
   Schomerus G, 2022, J HEPATOL, V77, P516, DOI 10.1016/j.jhep.2022.04.026
   Setiawan VW, 2016, HEPATOLOGY, V64, P1969, DOI 10.1002/hep.28677
   Shiha G, 2022, J HEPATOL, V77, P1717, DOI 10.1016/j.jhep.2022.08.027
   Sullivan SM, 2014, PREV MED, V61, P1, DOI 10.1016/j.ypmed.2013.12.023
   Sumida Y, 2014, J PUBLIC HEALTH-UK, V36, P629, DOI 10.1093/pubmed/fdt098
   Tomeno W, 2015, J GASTROEN HEPATOL, V30, P1009, DOI 10.1111/jgh.12897
   WHO, 2004, LANCET, V363, P902, DOI 10.1016/S0140-6736(03)15268-3
   Wu YK, 2018, J ADV NURS, V74, P1030, DOI 10.1111/jan.13511
   Younossi Z, 2018, NAT REV GASTRO HEPAT, V15, P11, DOI 10.1038/nrgastro.2017.109
   Younossi ZM, 2021, GASTROENTEROLOGY, V160, P912, DOI 10.1053/j.gastro.2020.11.051
   Younossi ZM, 2018, LIVER TRANSPLANT, V24, P166, DOI 10.1002/lt.25003
   Younossi ZM, 2013, METABOLISM, V62, P352, DOI 10.1016/j.metabol.2012.08.005
NR 58
TC 6
Z9 6
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2055-2238
J9 OBES SCI PRACT
JI OBES. SCI. PRACT.
PD DEC
PY 2023
VL 9
IS 6
BP 581
EP 589
DI 10.1002/osp4.688
EA JUN 2023
PG 9
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA CB5Q6
UT WOS:001013900900001
PM 38090690
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Basrak, N
   Mulcrone, N
   Sharifuddin, S
   Ghumman, Z
   Bechan, N
   Mohamed, E
   Murray, M
   Rajendran, H
   Gunnigle, S
   Nolan, M
   Quane, T
   Terao, M
   Hoare, T
   Kirrane, K
   Kennedy, HG
   Davoren, M
AF Basrak, Natasa
   Mulcrone, Naoise
   Sharifuddin, Sue
   Ghumman, Zeshan
   Bechan, Nirvana
   Mohamed, Enas
   Murray, Michael
   Rajendran, Hariharan
   Gunnigle, Sean
   Nolan, Mark
   Quane, Tim
   Terao, Masashi
   Hoare, Tracey
   Kirrane, Kevin
   Kennedy, Harry G.
   Davoren, Mary
TI Risk of adverse outcome of COVID-19 among patients in secure psychiatric
   services: observational cohort study
SO BJPSYCH OPEN
LA English
DT Article
DE COVID-19; schizophrenia; forensic mental health services; risk
   assessment; obesity
ID METABOLIC SYNDROME; SCHIZOPHRENIA
AB Background
   Secure forensic mental health services treat patients with high rates of treatment-resistant psychoses. High rates of obesity and medical comorbidities are common. Population-based studies have identified high-risk groups in the event of SARS-CoV-2 infection, including those with problems such as obesity, lung disease and immune-compromising conditions. Structured assessment tools exist to ascertain the risk of adverse outcome in the event of SARS-CoV-2 infection.
   Aims
   To assess risk of adverse outcome in the event of SARS-CoV-2 infection in a complete population of forensic psychiatry patients using structured assessment tools.
   Method
   All patients of a national forensic mental health service (n = 141) were rated for risk of adverse outcome in the event of SARS-CoV-2 infection, using two structured tools, the COVID-Age tool and the COVID-Risk tool.
   Results
   We found high rates of relevant physical comorbidities. Mean chronological age was 45.5 years (s.d. = 11.4, median 44.1), mean score on the COVID-Age tool was 59.1 years (s.d. = 19.4, median 58.0), mean difference was 13.6 years (s.d. = 15.6), paired t = 10.9, d.f. = 140, P < 0.001. Three patients (2.1%) were chronologically over 70 years of age, compared with 43 (30.5%) with a COVID-Age over 70 (chi(2) = 6.99, d.f. = 1, P = 0.008, Fisher's exact test P = 0.027).
   Conclusions
   Patients in secure forensic psychiatric services represent a high-risk group for adverse outcomes in the event of SARS-COV-2 infection. Population-based guidance on self-isolation and other precautions based on chronological age may not be sufficient. There is an urgent need for better physical health research and treatment in this group.
C1 [Basrak, Natasa; Mulcrone, Naoise; Sharifuddin, Sue; Ghumman, Zeshan; Bechan, Nirvana; Mohamed, Enas; Murray, Michael; Rajendran, Hariharan; Gunnigle, Sean; Nolan, Mark; Quane, Tim; Terao, Masashi; Hoare, Tracey; Kirrane, Kevin; Kennedy, Harry G.; Davoren, Mary] Cent Mental Hosp, Natl Forens Mental Hlth Serv, Dublin, Ireland.
   [Nolan, Mark; Davoren, Mary] Trinity Coll Dublin, DUNDRUM Ctr Forens Excellence, Dublin, Ireland.
C3 Trinity College Dublin
RP Davoren, M (corresponding author), Cent Mental Hosp, Natl Forens Mental Hlth Serv, Dublin, Ireland.; Davoren, M (corresponding author), Trinity Coll Dublin, DUNDRUM Ctr Forens Excellence, Dublin, Ireland.
EM davorem@tcd.ie
RI Kennedy, Harry/AAE-6401-2020
OI Davoren, Mary/0000-0002-8054-298X; Kennedy, Harry G/0000-0003-3174-3272
CR Banerjee A, 2020, LANCET, V395, P1715, DOI 10.1016/S0140-6736(20)30854-0
   Barnett AH, 2007, J PSYCHOPHARMACOL, V21, P357, DOI 10.1177/0269881107075509
   Coggon D, 2020, OCCUP MED-OXFORD, V70, P461, DOI 10.1093/occmed/kqaa150
   Coid J, 2000, BRIT J PSYCHIAT, V177, P241, DOI 10.1192/bjp.177.3.241
   Comas-Herrera A, 2021, Mortality associated with COVID-19 outbreaks in care homes: International evidence
   Davoren M, 2015, BMC PSYCHIATRY, V15, DOI 10.1186/s12888-015-0686-4
   Day M, 2020, BMJ-BRIT MED J, V369, DOI 10.1136/bmj.m1375
   English P, 2020, MEDRXIV, DOI [10.1101/2020.05.05.20091967, DOI 10.1101/2020.05.05.20091967]
   Eubank S, 2020, B MATH BIOL, V82, DOI 10.1007/s11538-020-00726-x
   Fisman DN, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.15957
   Guan W, 2020, NEW ENGL J MED, V382, P1708, DOI 10.1056/NEJMoa2002032
   Habersaat KB, 2020, NAT HUM BEHAV, V4, P677, DOI 10.1038/s41562-020-0906-x
   Hanratty B, 2020, BMJ-BRIT MED J, V369, DOI 10.1136/bmj.m2463
   Huang CL, 2020, LANCET, V395, P497, DOI 10.1016/S0140-6736(20)30183-5
   Huband N, 2018, INT J FORENSIC MENT, V17, P45, DOI 10.1080/14999013.2017.1405124
   Kennedy HG, 2021, IRISH J PSYCHOL MED, V38, P145, DOI 10.1017/ipm.2020.58
   Lee SW, 2020, LANCET PSYCHIAT, V7, P1025, DOI 10.1016/S2215-0366(20)30421-1
   Leonard BE, 2012, J PSYCHOPHARMACOL, V26, P33, DOI 10.1177/0269881111431622
   McCullough S, 2020, BJPSYCH OPEN, V6, DOI 10.1192/bjo.2020.61
   McMichael TM, 2020, NEW ENGL J MED, V382, P2005, DOI 10.1056/NEJMoa2005412
   Meyer JM, 2009, ACTA PSYCHIAT SCAND, V119, P4, DOI 10.1111/j.1600-0447.2008.01317.x
   Mizumoto K, 2020, EUROSURVEILLANCE, V25, P2, DOI 10.2807/1560-7917.ES.2020.25.10.2000180
   O'Reilly K, 2015, BMC PSYCHIATRY, V15, DOI 10.1186/s12888-015-0548-0
   Oliver D, 2020, BMJ-BRIT MED J, V369, DOI 10.1136/bmj.m2334
   Onder G, 2020, JAMA-J AM MED ASSOC, V323, P1775, DOI 10.1001/jama.2020.4683
   Perera Bhathika, 2020, BJPsych Open, V6, pe123, DOI 10.1192/bjo.2020.102
   Perez-Guzman Pablo N, 2021, Clin Infect Dis, V73, pe4047, DOI 10.1093/cid/ciaa1091
   Pillay Selena M., 2008, Irish Journal of Psychological Medicine, V25, P123, DOI 10.1017/S0790966700011228
   Ruan QR, 2020, INTENS CARE MED, V46, P846, DOI 10.1007/s00134-020-05991-x
   Saloner B, 2020, JAMA-J AM MED ASSOC, V324, P602, DOI 10.1001/jama.2020.12528
   Simpson AIF, 2020, CAN J PSYCHIAT, V65, P695, DOI 10.1177/0706743720935648
   Thakore JH, 2005, BRIT J PSYCHIAT, V186, P455, DOI 10.1192/bjp.186.6.455
   Thompson JW, 2020, PSYCHIAT SERV, V71, P1285, DOI 10.1176/appi.ps.202000270
   Verity R, 2020, LANCET INFECT DIS, V20, P669, DOI 10.1016/S1473-3099(20)30243-7
   Walker P. G. T., 2020, 12 IMP COLL LOND, DOI DOI 10.25561/77735
   Wang QQ, 2021, WORLD PSYCHIATRY, V20, P124, DOI 10.1002/wps.20806
   Warren N, 2021, JAMA PSYCHIAT, V78, P589, DOI 10.1001/jamapsychiatry.2020.4396
   Werneke U, 2020, DEATH ASS CORONAVIRU, DOI [10.1101/2020.09.14.20193987, DOI 10.1101/2020.09.14.20193987]
   Williams HK, 2020, BJPSYCH OPEN, V6, DOI 10.1192/bjo.2020.35
   Williamson EJ, 2020, NATURE, V584, P430, DOI 10.1038/s41586-020-2521-4
   Xie JF, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.5619
   Zhu N, 2020, NEW ENGL J MED, V382, P727, DOI [10.1056/NEJMoa2001017, 10.1172/JCI89857]
NR 42
TC 6
Z9 6
U1 1
U2 3
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2056-4724
J9 BJPSYCH OPEN
JI BJPsych Open
PD JAN 11
PY 2021
VL 7
IS 1
AR e31
DI 10.1192/bjo.2020.169
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA PU3YA
UT WOS:000609239600001
PM 33427191
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mccormick, BP
   Frey, G
   Lee, CT
   Chun, S
   Sibthorp, J
   Gajic, T
   Stamatovic-Gajic, B
   Maksimovich, M
AF Mccormick, Bryan P.
   Frey, Georgia
   Lee, Chien-Tsung
   Chun, Sanghee
   Sibthorp, Jim
   Gajic, Tomislav
   Stamatovic-Gajic, Branka
   Maksimovich, Milena
TI PREDICTING TRANSITORY MOOD FROM PHYSICAL ACTIVITY LEVEL AMONG PEOPLE
   WITH SEVERE MENTAL ILLNESS IN TWO CULTURES
SO INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY
LA English
DT Article
DE physical activity; mood; experience sampling; accelerometry
ID METABOLIC SYNDROME; AEROBIC EXERCISE; PSYCHIATRIC REHABILITATION;
   ENERGY-EXPENDITURE; DAILY-LIFE; HEALTH; DEPRESSION; SCHIZOPHRENIA;
   INTERVENTION; INDIVIDUALS
AB Background: Previous studies have indicated that physical activity (PA) is positively related to health-related quality of life and well-being among people with severe mental illness (SMI). Physical activity is broadly defined in this research as any skeletal muscle movement resulting in energy expenditure, including common daily activities such as housework and gardening, as well as walking for transportation and formal exercise. Although the physical health benefits of PA are well documented, evidence suggests that PA provides psychological benefits as well.
   Aims: The purpose of this study was to identify if PA level was associated with transitory mood in the everyday lives of people with SMI across two cultures.
   Methods: Subjects were drawn through mental health centres in Serbia (n = 12) and the USA (n = 11). Data were collected using both experience sampling methodology and accelerometry. Data were analyzed using hierarchical linear modelling.
   Results: Subjects demonstrated low levels of PA, which did not differ significantly between groups. Hierarchical analysis indicated that PA remained significantly positively associated with mood after accounting for individual variation, and this was consistent across groups.
   Conclusions: This study reinforces previous findings that people with SMI demonstrate low PA levels generally. It also supports the consideration of physical activity interventions as a regular part of psychiatric rehabilitation. It appears that increased PA may have the potential to affect both physical health and mood among people with SMI.
C1 [Mccormick, Bryan P.; Lee, Chien-Tsung] Indiana Univ, Dept Kinesiol, Bloomington, IN 47405 USA.
   [Chun, Sanghee] Indiana Univ, Dept Recreat Pk & Tourism Studies, Bloomington, IN 47405 USA.
   [Sibthorp, Jim] Univ Utah, Salt Lake City, UT USA.
   [Gajic, Tomislav; Stamatovic-Gajic, Branka; Maksimovich, Milena] Hlth Ctr Valjevo, Dept Psychiat, Valjevo, Serbia.
C3 Indiana University System; Indiana University Bloomington; Indiana
   University System; Indiana University Bloomington; Utah System of Higher
   Education; University of Utah
RP Mccormick, BP (corresponding author), Indiana Univ, Dept Kinesiol, Bloomington, IN 47405 USA.
EM bmccormi@indiana.edu
RI McCormick, Bryan/AER-1130-2022
OI Sibthorp, Jim/0000-0002-4574-9141
CR [Anonymous], B WHO
   [Anonymous], CLIN EXERCISE PHYSL
   [Anonymous], PHYSL BEHAV
   Bartholomew JB, 2005, MED SCI SPORT EXER, V37, P2032, DOI 10.1249/01.mss.0000178101.78322.dd
   Beebe LH, 2008, PERSPECT PSYCHIATR C, V44, P25, DOI 10.1111/j.1744-6163.2008.00144.x
   Brown DR, 2005, AM J HEALTH BEHAV, V29, P195, DOI 10.5993/AJHB.29.3.1
   Burbach F., 1997, J MENT HEALTH, V6, P543, DOI DOI 10.1080/09638239718428
   Callaghan P, 2004, J Psychiatr Ment Health Nurs, V11, P476, DOI 10.1111/j.1365-2850.2004.00751.x
   CASPERSEN CJ, 1985, PUBLIC HEALTH REP, V100
   Compton MT, 2006, HARVARD REV PSYCHIAT, V14, P212, DOI 10.1080/10673220600889256
   Craft LL, 1998, J SPORT EXERCISE PSY, V20, P339, DOI 10.1123/jsep.20.4.339
   CSIKSZENTMIHALYI M, 1987, J NERV MENT DIS, V175, P526, DOI 10.1097/00005053-198709000-00004
   Daumit GL, 2005, J NERV MENT DIS, V193, P641, DOI 10.1097/01.nmd.0000180737.85895.60
   De Leon J, 2007, SCHIZOPHR RES, V96, P185, DOI 10.1016/j.schres.2007.05.020
   Dickerson FB, 2006, ACTA PSYCHIAT SCAND, V113, P306, DOI 10.1111/j.1600-0447.2005.00637.x
   Dimeo F, 2001, BRIT J SPORT MED, V35, P114, DOI 10.1136/bjsm.35.2.114
   Faulkner G., 1999, J MENT HEALTH, V8, P441, DOI DOI 10.1080/09638239917157
   Faulkner G, 2006, PSYCHIATR REHABIL J, V29, P258, DOI 10.2975/29.2006.258.266
   Frey G., 2004, J PHYS ACTIVITY HLTH, V1, P235, DOI [DOI 10.1123/JPAH.1.3.235, 10.1123/jpah.1.3.235]
   HANNAFORD CP, 1988, PSYCHOL REC, V38, P37, DOI 10.1007/BF03395005
   Holland D, 2003, DISABIL SOC, V18, P133, DOI 10.1080/0968759032000052798
   Hopper K, 2000, SCHIZOPHRENIA BULL, V26, P835, DOI 10.1093/oxfordjournals.schbul.a033498
   Korszun A, 2002, J PSYCHOSOM RES, V52, P439, DOI 10.1016/S0022-3999(01)00237-9
   Kulhara P, 2001, PSYCHIAT CLIN N AM, V24, P449, DOI 10.1016/S0193-953X(05)70240-9
   Lawlor DA, 2001, BMJ-BRIT MED J, V322, P763, DOI 10.1136/bmj.322.7289.763
   LEFLEY HP, 1990, HOSP COMMUNITY PSYCH, V41, P277
   MARTINSEN EW, 1985, BRIT MED J, V291, P109, DOI 10.1136/bmj.291.6488.109
   MCCANN IL, 1984, J PERS SOC PSYCHOL, V46, P1142, DOI 10.1037/0022-3514.46.5.1142
   McCormick BP, 2005, J LEISURE RES, V37, P236, DOI 10.1080/00222216.2005.11950052
   McDevitt J, 2005, BIOL RES NURS, V7, P87, DOI 10.1177/1099800405278116
   Meyer T, 2000, SPORTS MED, V30, P269, DOI 10.2165/00007256-200030040-00003
   Millar A, 2004, J AFFECT DISORDERS, V80, P145, DOI 10.1016/S0165-0327(03)00055-7
   Myin-Germeys I, 2000, SCHIZOPHRENIA BULL, V26, P847, DOI 10.1093/oxfordjournals.schbul.a033499
   Myin-Germeys I, 2003, ACTA PSYCHIAT SCAND, V107, P124, DOI 10.1034/j.1600-0447.2003.02025.x
   Newcomer JW, 2007, AM J MANAG CARE, V13, pS170
   Osei-Tutu KB, 2005, PREV MED, V40, P92, DOI 10.1016/j.ypmed.2004.05.005
   Pelham T., 1993, PSYCHOSOC REHABIL J, V16, P75
   Richardson CR, 2005, PSYCHIAT SERV, V56, P324, DOI 10.1176/appi.ps.56.3.324
   Ruggeri M, 2000, BRIT J PSYCHIAT, V177, P149, DOI 10.1192/bjp.177.2.149
   Schmitz N, 2004, PREV MED, V39, P1200, DOI 10.1016/j.ypmed.2004.04.034
   Schwartz JE, 1998, HEALTH PSYCHOL, V17, P6, DOI 10.1037/0278-6133.17.1.6
   Sharpe JK, 2006, AUST NZ J PSYCHIAT, V40, P810, DOI 10.1111/j.1440-1614.2006.01888.x
   Skrinar GS, 2005, PSYCHIATR REHABIL J, V29, P122, DOI 10.2975/29.2005.122.127
   Stone Arthur S., 1994, Annals of Behavioral Medicine, V16, P199
   Swartz AM, 2000, MED SCI SPORT EXER, V32, pS450, DOI 10.1097/00005768-200009001-00003
   van Winkel R, 2008, BIPOLAR DISORD, V10, P342, DOI 10.1111/j.1399-5618.2007.00520.x
   Voelkl J. E., 2000, Therapeutic Recreation Journal, V34, P227
NR 47
TC 12
Z9 14
U1 0
U2 16
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0020-7640
EI 1741-2854
J9 INT J SOC PSYCHIATR
JI Int. J. Soc. Psychiatr.
PD NOV
PY 2008
VL 54
IS 6
BP 527
EP 538
DI 10.1177/0020764008091423
PG 12
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA 380VC
UT WOS:000261493000006
PM 18974191
DA 2025-06-11
ER

PT J
AU Lin, CH
   Chiang, SL
   Tzeng, WC
   Chiang, LC
AF Lin, Chia-Huei
   Chiang, Shang-Lin
   Tzeng, Wen-Chii
   Chiang, Li-Chi
TI Systematic Review of Impact of Lifestyle-Modification Programs on
   Metabolic Risks and Patient-Reported Outcomes in Adults With Metabolic
   Syndrome
SO WORLDVIEWS ON EVIDENCE-BASED NURSING
LA English
DT Review
DE lifestyle-modification program; metabolic risks; metabolic syndrome;
   patient-reported outcome; quality of life; systematic review
ID QUALITY-OF-LIFE; CARDIOVASCULAR-DISEASE; INTERVENTION; EXERCISE; TRIAL;
   METAANALYSIS; HYPERTENSION; MANAGEMENT
AB Background: Metabolic syndrome (MetS) is primarily attributed to an unhealthy lifestyle, which is a modifiable risk factor. Researchers have been exploring various strategies, including lifestyle-modification programs (LMPs), to prevent the progression of MetS. However, the effectiveness of LMPs on metabolic risks and patient-reported outcomes (PROs) among adults with MetS remains inconclusive.
   Aim: To evaluate the effectiveness of LMPs on the metabolic risks and PROs among adults with MetS.
   Methods: A systematic review of randomized controlled trials published from January 1985 to June 2014 was conducted. The review extracted LMP interventions that included outcomes on the metabolic risks and PROs (quality of life and any other psychological health indicators). The quality of the included studies was assessed using the Cochrane Collaboration criteria.
   Results: Among the five trials included, the most commonly applied intervention components were diet plans, supervised exercise, health education, individual counseling, behavioral modification, and motivational interviewing. Three fifths of the studies were nurse-led, and only one of the selected trials was theory-guided. LMPs can effectively reduce triglyceride levels, waist circumference, and systolic blood pressure. However, few trials consistently confirmed the benefits of metabolic risks, and none revealed a significant effect on high-density lipoprotein, fasting blood glucose, or any PRO, except quality of life. The duration of LMPs in the included trials ranged from 4 to 24 weeks, and durations of at least 12 weeks significantly improved quality of life.
   Linking Evidence to Action: LMPs had positive effects on some metabolic risks and on quality of life, whereas longer-duration LMPs may have highly beneficial effects on quality of life. The essential elements of LMPs need to be evaluated more thoroughly to determine their effectiveness. Larger and more rigorous randomized controlled trials are required to assess the effectiveness of LMPs on metabolic risks and PROs among adults with MetS.
C1 [Lin, Chia-Huei] Natl Def Med Ctr, Grad Inst Med Sci, Taipei, Taiwan.
   [Lin, Chia-Huei; Chiang, Li-Chi] Natl Def Med Ctr, Sch Nursing, Taipei, Taiwan.
   [Lin, Chia-Huei] Tri Serv Gen Hosp, Dept Nursing, Taipei, Taiwan.
   [Chiang, Shang-Lin] Tri Serv Gen Hosp, Dept Phys Med & Rehabil, Taipei, Taiwan.
   [Chiang, Shang-Lin] Natl Yang Ming Univ, Taipei 112, Taiwan.
   [Tzeng, Wen-Chii] Tri Serv Gen Hosp, Dept Nursing, Taipei, Taiwan.
   [Tzeng, Wen-Chii] Natl Def Med Ctr, Taipei, Taiwan.
   [Chiang, Li-Chi] China Med Univ, Sch Nursing, Taichung, Taiwan.
C3 National Defense Medical Center; National Defense Medical Center;
   Tri-Service General Hospital; Tri-Service General Hospital; National
   Yang Ming Chiao Tung University; Tri-Service General Hospital; National
   Defense Medical Center; China Medical University Taiwan
RP Chiang, LC (corresponding author), 161,Sec 6,Minquan E Rd, Taipei 114, Taiwan.
EM lichichiang@gmail.com
RI Lin, Chia-Huei/GLQ-5499-2022; Chiang, Li-Chi/AAW-9661-2020; Tzeng,
   Wen-Chii/M-4214-2014
OI Chiang, Li-Chi/0000-0002-6383-7495; Tzeng, Wen-Chii/0000-0002-4205-896X;
   Lin, Chia-Huei/0000-0003-3751-602X; Lin, Chia-Huei/0000-0002-5557-9668
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   [Anonymous], COCHRANE HDB SYSTEMA
   Carroll S, 2007, APPL PHYSIOL NUTR ME, V32, P125, DOI 10.1139/h06-093
   Chen SF, 2010, J CLIN NURS, V19, P2713, DOI 10.1111/j.1365-2702.2010.03320.x
   Cramer H, 2014, INT J CARDIOL, V173, P170, DOI 10.1016/j.ijcard.2014.02.017
   Da Costa D, 2009, J PSYCHOSOM OBST GYN, V30, P191, DOI 10.1080/01674820903212136
   Devereaux P J, 2002, Evid Based Ment Health, V5, P36, DOI 10.1136/ebn.5.2.36
   Fitch KV, 2006, AIDS, V20, P1843, DOI 10.1097/01.aids.0000244203.95758.db
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Kukkonen-Harjula KT, 2005, PREV MED, V41, P784, DOI 10.1016/j.ypmed.2005.07.008
   Martin CK, 2009, ARCH INTERN MED, V169, P269, DOI 10.1001/archinternmed.2008.545
   Meigs JB, 2006, J CLIN ENDOCR METAB, V91, P2906, DOI 10.1210/jc.2006-0594
   Miettola J, 2008, QUAL LIFE RES, V17, P1055, DOI 10.1007/s11136-008-9386-6
   Nanri A, 2012, J OCCUP HEALTH, V54, P215, DOI 10.1539/joh.11-0238-OA
   New JP, 2003, DIABETES CARE, V26, P2250, DOI 10.2337/diacare.26.8.2250
   Oh EG, 2010, METABOLISM, V59, P1035, DOI 10.1016/j.metabol.2009.10.027
   Oh EG, 2008, METABOLISM, V57, P255, DOI 10.1016/j.metabol.2007.09.009
   Orchard TJ, 2005, ANN INTERN MED, V142, P611, DOI 10.7326/0003-4819-142-8-200504190-00009
   Parker WA, 2011, PUBLIC HEALTH NUTR, V14, P1429, DOI 10.1017/S1368980009993272
   Pokladnikova J, 2013, J ASTHMA, V50, P318, DOI 10.3109/02770903.2012.759587
   Pritchett Allison M, 2012, J Obes Weight Loss Ther, V2, P1
   Pulkki-Råback L, 2009, HEALTH PSYCHOL, V28, P108, DOI 10.1037/a0012646
   SCHULZ KF, 1995, JAMA-J AM MED ASSOC, V273, P408, DOI 10.1001/jama.273.5.408
   Thomasouli MA, 2013, SLEEP BREATH, V17, P925, DOI 10.1007/s11325-013-0806-7
   Van Camp YP, 2013, EUR J CLIN PHARMACOL, V69, P761, DOI 10.1007/s00228-012-1419-y
   Yamaoka K, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-138
   Yasein N., 2010, Eastern Mediterranean Health Journal, V16, P375
NR 28
TC 47
Z9 55
U1 0
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1545-102X
EI 1741-6787
J9 WORLDV EVID-BASED NU
JI Worldviews Evid.-Based Nurs.
PD DEC
PY 2014
VL 11
IS 6
BP 361
EP 368
DI 10.1111/wvn.12069
PG 8
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA AW1FH
UT WOS:000346035300003
PM 25488565
DA 2025-06-11
ER

PT J
AU Partsernyak, AS
   Polyakova, VO
   Trufanov, AG
   Medvedev, DS
   Trotsyuk, DV
   Markin, K
   Kurasov, ES
   Kuznetsova, EV
   Krasichkov, AS
AF Partsernyak, Alexander S.
   Polyakova, Victoria O.
   Trufanov, Artem G.
   Medvedev, Dmitriy S.
   Trotsyuk, Dina V.
   Markin, Kirill
   Kurasov, Evgeniy S.
   Kuznetsova, Evgeniya V.
   Krasichkov, Alexander S.
TI Melatonin: Manager of psychosomatic and metabolic disorders in
   polymorbid cardiovascular pathology
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Article
DE melatonin; circadian rhythms; metabolic syndrome; polymorbidity;
   cardiovascular pathology; anxiety and depressive disorders; young men;
   glucose
ID BLOOD-PRESSURE; MYOCARDIAL-INFARCTION; INSULIN SENSITIVITY; SLEEP;
   LEPTIN; RESISTANCE; HEART; NIGHT; CARDIOPROTECTION; DISEASE
AB ObjectivesTo investigate the relationship between changes in circadian patterns of melatonin and clinical manifestations of polymorbid cardiovascular pathology (PCVP) in young men and to analyze the effectiveness of their complex treatment. Materials and methodsWe made the immunohistochemical (IHC) analysis of epiphysis tissues from autopsies of 25 men aged 32-44 with PCVP and metabolic syndrome (MS) who had died as a result of ischemic cardiomyopathy (IC) and 25 persons after the car accident as a control group. Then, 93 young men aged 35-44 with PCVP, metabolic syndrome, and depressive spectrum disorders (DSD) were divided into three groups: (1) standard therapy; (2) standard therapy and psychotherapy sessions; (3) standard therapy in combination with psychotherapeutic and psychophysiological visual and auditory correction sessions. The control group included 24 conditionally healthy male volunteers. Before and after the treatment, we studied the anthropometric status, lipid and carbohydrate metabolism indicators, the level of urinary 6-hydroxymelatonin sulfate, the degree of nocturnal decrease in blood pressure (BP), and the relationship of these indicators with circadian variations of melatonin excretion. ResultsYoung polymorbid patients who died from IC have a lower expression of melatonin type 1 and 2 receptors. All patients with PCVP showed a decrease in the nocturnal melatonin excretion fraction and a correlation with higher severity of depressive (r = -0.72) and anxiety (r = -0.66) symptoms. Reduced values of the 6-hydroxymelatonin sulfate (6-SM) in the 1st (r = 0.45), 2nd (r = 0.39), and 3rd (r = 0.51) groups before treatment was associated with periods of increased BP. The achievement of melatonin excretion reference values and normalization of biochemical parameters of carbohydrate and lipid metabolism, daily BP profile, and psychophysiological state were noted in all three patients' groups, with a more pronounced effect in group 3. ConclusionLow nocturnal melatonin excretion levels are associated with greater severity of clinical symptoms and a higher risk of death in patients with PCVP. Therefore, comprehensive therapy may be more effective for correcting this disease.
C1 [Partsernyak, Alexander S.] Kirov Mil Med Acad, Dept Mil Field Therapy, St Petersburg, Russia.
   [Polyakova, Victoria O.] St Petersburg Res Inst Phthisiopulmonol, Ctr Mol Biomed, St Petersburg, Russia.
   [Trufanov, Artem G.] Kirov Mil Med Acad, Dept Neurol, St Petersburg, Russia.
   [Trufanov, Artem G.] St Petersburg Electrotech Univ LETI, Dept Software Engn & Comp Applicat, St Petersburg, Russia.
   [Medvedev, Dmitriy S.] Fed Med Biol Agcy Russia, Dept Physiol Assessment & Med Correct, Res Inst Hyg Occupat Pathol & Human Ecol, Kuzmolovsky, Russia.
   [Trotsyuk, Dina V.] St Petersburg Med & Social Inst, Dept Internal Dis, Private Educ Inst Higher Educ, St Petersburg, Russia.
   [Markin, Kirill; Kurasov, Evgeniy S.] Kirov Mil Med Acad, Dept Psychiat, St Petersburg, Russia.
   [Kuznetsova, Evgeniya V.] Kirov Mil Med Acad, Dept Med Supply, St Petersburg, Russia.
   [Krasichkov, Alexander S.] St Petersburg Electrotech Univ LETI, Dept Radio Engn Syst, St Petersburg, Russia.
C3 St. Petersburg State Research Institute of Phthisiopulmonology; Saint
   Petersburg State Electrotechnical University; Saint Petersburg State
   Electrotechnical University
RP Partsernyak, AS (corresponding author), Kirov Mil Med Acad, Dept Mil Field Therapy, St Petersburg, Russia.
EM partsernyak@mail.ru
RI Markin, Kirill/AAX-2975-2021; Medvedev, Dmitry/D-4986-2017; Partsernyak,
   Alexander/LWK-1525-2024; Trufanov, Artem/W-2584-2017
OI Markin, Kirill/0000-0002-6242-1279
FU Development Program of ETU LETI;  [075-15-2021-1318]
FX Funding This research was funded by the Development Program of ETU LETI
   within the framework of the program of Strategic Academic Leadership
   Priority-2030 No. 075-15-2021-1318 on 29 September 2021.
CR Al-Ghoul WM, 2010, INT J BIOL SCI, V6, P282
   Allada R, 2021, NEW ENGL J MED, V384, P550, DOI 10.1056/NEJMra1802337
   Altun A, 2002, NEUROSCI LETT, V327, P143, DOI 10.1016/S0304-3940(02)00368-3
   Anderson G, 2015, CURR PSYCHIAT REP, V17, DOI 10.1007/s11920-014-0541-1
   Beccuti G, 2011, CURR OPIN CLIN NUTR, V14, P402, DOI 10.1097/MCO.0b013e3283479109
   Besharse JC, 2016, J BIOL RHYTHM, V31, P223, DOI 10.1177/0748730416642657
   Blüher M, 2015, METABOLISM, V64, P131, DOI 10.1016/j.metabol.2014.10.016
   BROWN GM, 1991, J PINEAL RES, V10, P141, DOI 10.1111/j.1600-079X.1991.tb00831.x
   Buxton OM, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3003200
   Alonso-Vale MIC, 2008, J PINEAL RES, V45, P422, DOI 10.1111/j.1600-079X.2008.00610.x
   Cimpean D, 2011, EPIDEMIOL PSYCH SCI, V20, P141, DOI 10.1017/S2045796011000345
   Cui HX, 2017, NAT REV ENDOCRINOL, V13, P338, DOI 10.1038/nrendo.2016.222
   Cui NQ, 2022, FRONT MED-LAUSANNE, V9, DOI 10.3389/fmed.2022.806945
   Domínguez-Rodríguez A, 2002, J PINEAL RES, V33, P248, DOI 10.1034/j.1600-079X.2002.02938.x
   Dominguez-Rodriguez A, 2017, HEART, V103, P647, DOI 10.1136/heartjnl-2016-310689
   Dominguez-Rodriguez A, 2014, WORLD J CARDIOL, V6, P100, DOI 10.4330/wjc.v6.i3.100
   Dominguez-Rodriguez A, 2010, J PINEAL RES, V49, P14, DOI 10.1111/j.1600-079X.2010.00773.x
   Dyar KA, 2014, MOL METAB, V3, P29, DOI 10.1016/j.molmet.2013.10.005
   Eckel-Mahan K, 2013, PHYSIOL REV, V93, P107, DOI 10.1152/physrev.00016.2012
   Espino J, 2011, WORLD J DIABETES, V2, P82, DOI 10.4239/wjd.v2.i6.82
   Garcia-Argibay M, 2019, PSYCHOL RES-PSYCH FO, V83, P357, DOI 10.1007/s00426-018-1066-8
   Gill S, 2015, CELL METAB, V22, P789, DOI 10.1016/j.cmet.2015.09.005
   Girotti L, 2003, ENDOCRINE, V22, P245, DOI 10.1385/ENDO:22:3:245
   Greene MW, 2012, CANCER LETT, V318, P115, DOI 10.1016/j.canlet.2012.01.001
   Grossman E, 2006, AM J MED, V119, P898, DOI 10.1016/j.amjmed.2006.02.002
   Hare DL, 2014, EUR HEART J, V35, P1365, DOI 10.1093/eurheartj/eht462
   IIGO M, 1995, NEUROSCI LETT, V197, P61, DOI 10.1016/0304-3940(95)11903-A
   Jin Jing, 2008, Ther Clin Risk Manag, V4, P269
   Kahl KG, 2022, FRONT PSYCHIATRY, V13, DOI 10.3389/fpsyt.2022.831359
   Kalsbeek A, 2001, ENDOCRINOLOGY, V142, P2677, DOI 10.1210/en.142.6.2677
   Kettner NM, 2015, CELL METAB, V22, P448, DOI 10.1016/j.cmet.2015.06.005
   Kimak E, 2014, CURR ISS PHARM MED S, V27, P159, DOI 10.1515/cipms-2015-0007
   Koziróg M, 2011, J PINEAL RES, V50, P261, DOI 10.1111/j.1600-079X.2010.00835.x
   Kurylowicz A., 2020, MOL BASEL SWITZ, V25, pE2224
   Laermans J, 2015, SCI REP-UK, V5, DOI 10.1038/srep16748
   Lochner Amanda, 2013, Front Biosci (Elite Ed), V5, P305
   Lucassen EA, 2012, ANN NY ACAD SCI, V1264, P110, DOI 10.1111/j.1749-6632.2012.06655.x
   Marcheva B, 2010, NATURE, V466, P627, DOI 10.1038/nature09253
   Mozdzan M, 2014, ARCH MED SCI, V10, P669, DOI 10.5114/aoms.2014.44858
   Mullington JM, 2003, J NEUROENDOCRINOL, V15, P851, DOI 10.1046/j.1365-2826.2003.01069.x
   Nikitenko LL, 2002, TRENDS PHARMACOL SCI, V23, P101, DOI 10.1016/S0165-6147(00)01983-0
   Paredes SD, 2014, HORM MOL BIOL CLIN I, V18, P79, DOI 10.1515/hmbci-2014-0016
   Paulis L, 2007, PHYSIOL RES, V56, P671, DOI 10.33549/physiolres.931236
   Pechanova O, 2014, INT J MOL SCI, V15, P17920, DOI 10.3390/ijms151017920
   Perelis M, 2015, SCIENCE, V350, DOI 10.1126/science.aac4250
   Pilling S, 2009, BMJ-BRIT MED J, V339, DOI 10.1136/bmj.b4108
   Poggiogalle E, 2018, METABOLISM, V84, P11, DOI 10.1016/j.metabol.2017.11.017
   Reiter RJ, 2016, J PINEAL RES, V61, P253, DOI 10.1111/jpi.12360
   Satyanarayanan SK, 2018, CURR PHARM DESIGN, V24, P2549, DOI 10.2174/1381612824666180803112304
   Schmid SM, 2008, J SLEEP RES, V17, P331, DOI 10.1111/j.1365-2869.2008.00662.x
   Shan ZL, 2015, DIABETES CARE, V38, P529, DOI 10.2337/dc14-2073
   Shi SQ, 2013, CURR BIOL, V23, P372, DOI 10.1016/j.cub.2013.01.048
   Simko F, 2016, J PINEAL RES, V61, P127, DOI 10.1111/jpi.12348
   Tan DX, 1998, J PINEAL RES, V25, P184, DOI 10.1111/j.1600-079X.1998.tb00558.x
   Tanimura Y, 2016, PHYSIOL REP, V4, DOI 10.14814/phy2.12828
   Tully PJ, 2016, CURR CARDIOL REP, V18, DOI 10.1007/s11886-016-0800-3
   VanCauter E, 1997, ENDOCR REV, V18, P716, DOI 10.1210/er.18.5.716
   Vilagut G, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0155431
   Vos T, 2020, LANCET, V396, P1562
   World Med Assoc, 2013, JAMA-J AM MED ASSOC, V310, P2191, DOI 10.1001/jama.2013.281053
   Wozniak SE, 2009, DIGEST DIS SCI, V54, P1847, DOI 10.1007/s10620-008-0585-3
   Wu Y, 2021, BMJ-BRIT MED J, V373, DOI 10.1136/bmj.n972
   Yang Y, 2015, J PINEAL RES, V58, P61, DOI 10.1111/jpi.12193
   Zhou B, 2014, HEPATOLOGY, V59, P2196, DOI 10.1002/hep.26992
   Zizi F, 2010, CURR DIABETES REP, V10, P43, DOI 10.1007/s11892-009-0082-x
NR 65
TC 0
Z9 0
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD SEP 28
PY 2022
VL 16
AR 989497
DI 10.3389/fnins.2022.989497
PG 11
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 5I3TR
UT WOS:000868283800001
PM 36248667
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Herr, RM
   Barrech, A
   Gündel, H
   Lang, J
   Quinete, NS
   Angerer, P
   Li, J
AF Herr, Raphael M.
   Barrech, Amira
   Guendel, Harald
   Lang, Jessica
   Quinete, Natalia Soares
   Angerer, Peter
   Li, Jian
TI Effects of psychosocial work characteristics on hair cortisol - findings
   from a post-trial study
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Article
DE Work stress; effort-reward imbalance; change; longitudinal; hair
   cortisol; job security
ID EFFORT-REWARD-IMBALANCE; BODY-MASS INDEX; CORONARY-HEART-DISEASE;
   METABOLIC SYNDROME; CHRONIC STRESS; MENTAL-HEALTH; SALIVARY CORTISOL;
   FUTURE-DIRECTIONS; BLOOD-PRESSURE; JOB STRAIN
AB Prolonged work stress, as indicated by the effort-reward imbalance (ERI) model, jeopardizes health. Cortisol represents a candidate mechanism connecting stress to ill health. However, previous findings appear inconclusive, and recommendations were made to assess work stress at multiple time points and also to investigate ERI (sub-)components. This study therefore examines the effects of two single time points, as well as the mean and change scores between time points of ERI and its components on hair cortisol concentration (HCC), a long-term cortisol measurement. Participants were 66 male factory workers (age: 40.68 +/- 6.74years; HCC: 9.007.11pg/mg), who were followed up after a stress management intervention (2006-2008). In 2008 (T1) and 2015 (T2), participants completed a 23-item ERI questionnaire, assessing effort, the three reward components (esteem, job security, job promotion) and over-commitment. In 2015, participants also provided a 3-cm hair segment close to the scalp for HCC analysis, as well as information on relevant confounders (i.e. medication intake, age, work characteristics, socioeconomic and lifestyle factors, number of stressful life events). Linear regressions revealed hardly any cross-sectional or longitudinal effect of ERI and its components on HCC. Only the change scores between T1 and T2 of job security were negatively associated with lower HCC in unadjusted (beta = -.320; p=.009) and adjusted (beta =-.288; p=.044) models. In this study, only a decrease of perceived job security over time was significantly associated with higher HCC, and other predictors were not related to this outcome. Especially after correction for multiple testing, this study revealed just a weak association of different psychosocial
   Lay summary
   This study showed that an increase in perceived job insecurity is correlated with higher levels of the stress hormone cortisol. The higher levels of cortisol might represent a biological explanation for the negative health effects of job insecurity. The association was, however, relatively low, and more and more voices are questioning whether cortisol in hair is a reliable marker for perceived work stress.work measurements with HCC.
C1 [Herr, Raphael M.; Barrech, Amira; Angerer, Peter; Li, Jian] Heinrich Heine Univ Dusseldorf, Fac Med, Ctr Hlth & Soc, Inst Occupat Social & Environm Med, Univ Str 1, D-40225 Dusseldorf, Germany.
   [Herr, Raphael M.] Heidelberg Univ, Med Fac Mannheim, Mannheim Inst Publ Hlth Social & Prevent Med, Mannheim, Germany.
   [Barrech, Amira; Guendel, Harald] Univ Ulm, Dept Psychosomat Med, Ulm, Germany.
   [Lang, Jessica; Quinete, Natalia Soares] Rhein Westfal TH Aachen, Inst Occupat & Social Med, Aachen, Germany.
C3 Heinrich Heine University Dusseldorf; Ruprecht Karls University
   Heidelberg; Ulm University; RWTH Aachen University
RP Herr, RM (corresponding author), Heinrich Heine Univ Dusseldorf, Fac Med, Ctr Hlth & Soc, Inst Occupat Social & Environm Med, Univ Str 1, D-40225 Dusseldorf, Germany.
EM raphael.herr@medma.uni-heidelberg.de
RI Gündel, Harald/AAZ-2905-2020; Herr, Raphael/GYU-5115-2022; Soares
   Quinete, Natalia/J-5100-2014
OI Soares Quinete, Natalia/0000-0001-9486-2995
FU German Federal Ministry of Education and Research (BMBF) [01EL1409B]
FX This work was supported by the German Federal Ministry of Education and
   Research (BMBF) under Grant No. 01EL1409B.
CR Almadi T, 2013, PSYCHOPHYSIOLOGY, V50, P821, DOI 10.1111/psyp.12069
   Bellingrath S, 2008, BIOL PSYCHOL, V78, P104, DOI 10.1016/j.biopsycho.2008.01.006
   Buddeberg-Fischer B, 2008, INT ARCH OCC ENV HEA, V82, P31, DOI 10.1007/s00420-008-0303-7
   Chandola T, 2005, OCCUP ENVIRON MED, V62, P223, DOI 10.1136/oem.2004.016675
   Eller NH, 2006, BIOL PSYCHOL, V73, P280, DOI 10.1016/j.biopsycho.2006.05.003
   Eller NH, 2012, BIOL PSYCHOL, V89, P342, DOI 10.1016/j.biopsycho.2011.11.007
   Gidlow CJ, 2016, PSYCHONEUROENDOCRINO, V63, P163, DOI 10.1016/j.psyneuen.2015.09.022
   Godin I, 2005, BMC PUBLIC HEALTH, V5, DOI 10.1186/1471-2458-5-67
   Hanson EKS, 2000, ANN BEHAV MED, V22, P316, DOI 10.1007/BF02895668
   Harris A, 2007, PSYCHONEUROENDOCRINO, V32, P322, DOI 10.1016/j.psyneuen.2007.01.003
   Irie M, 2004, INT ARCH OCC ENV HEA, V77, P409, DOI 10.1007/s00420-004-0533-2
   Izawa S, 2016, INT ARCH OCC ENV HEA, V89, P1147, DOI 10.1007/s00420-016-1154-2
   Janssens H, 2017, OCCUP MED-OXFORD, V67, P114, DOI 10.1093/occmed/kqw114
   Karlson B., 2012, ROLE SALIVA CORTISOL, P43, DOI DOI 10.2174/97816080534211120101
   Kim T. J., 2015, INT ARCH OCCUPATIONA, V89, P561, DOI DOI 10.1007/S00420-015-1107-1
   Kivimäki M, 2008, SCAND J WORK ENV HEA, P33
   Kivimäki M, 2006, PSYCHOSOM MED, V68, P398, DOI 10.1097/01.psy.0000221252.84351.e2
   Li J, 2013, AM J IND MED, V56, P1414, DOI 10.1002/ajim.22246
   Limm H, 2011, OCCUP ENVIRON MED, V68, P126, DOI 10.1136/oem.2009.054148
   Loerbroks A, 2015, INT J CARDIOL, V182, P390, DOI 10.1016/j.ijcard.2015.01.030
   Maina G, 2009, INT ARCH OCC ENV HEA, V82, P1141, DOI 10.1007/s00420-009-0439-0
   Manenschijn L, 2011, J CLIN ENDOCR METAB, V96, pE1862, DOI 10.1210/jc.2011-1551
   McEwen BS, 1998, ANN NY ACAD SCI, V840, P33, DOI 10.1111/j.1749-6632.1998.tb09546.x
   Nieuwenhuijsen K, 2010, OCCUP MED-OXFORD, V60, P277, DOI 10.1093/occmed/kqq081
   Ota A, 2014, SCI REP-UK, V4, DOI 10.1038/srep06402
   Pereg D, 2011, STRESS, V14, P73, DOI 10.3109/10253890.2010.511352
   Piazza JR, 2010, J GERONTOL B-PSYCHOL, V65, P513, DOI 10.1093/geronb/gbq049
   Qi XL, 2014, J PSYCHOSOM RES, V76, P329, DOI 10.1016/j.jpsychores.2014.01.008
   Quinete N, 2015, TALANTA, V134, P310, DOI 10.1016/j.talanta.2014.11.034
   Rosmalen JGM, 2012, PSYCHOL MED, V42, P2599, DOI 10.1017/S0033291712000608
   Russell E, 2012, PSYCHONEUROENDOCRINO, V37, P589, DOI 10.1016/j.psyneuen.2011.09.009
   Schmidt B, 2015, INT J CARDIOL, V178, P24, DOI 10.1016/j.ijcard.2014.10.115
   Schnall PL, 2016, INT J HEALTH SERV, V46, P656, DOI 10.1177/0020731416664687
   SHAFFER JP, 1995, ANNU REV PSYCHOL, V46, P561, DOI 10.1146/annurev.ps.46.020195.003021
   Siegrist J, 2004, SOC SCI MED, V58, P1483, DOI 10.1016/S0277-9536(03)00351-4
   Siegrist J, 1996, J Occup Health Psychol, V1, P27, DOI 10.1037/1076-8998.1.1.27
   Siegrist J, 2016, INT J ENV RES PUB HE, V13, DOI 10.3390/ijerph13040432
   Siegrist J, 2010, INT J OCCUP MED ENV, V23, P279, DOI 10.2478/v10001-010-0013-8
   Siegrist J, 2008, EUR ARCH PSY CLIN N, V258, P115, DOI 10.1007/s00406-008-5024-0
   Smith P, 2008, OCCUP ENVIRON MED, V65, P288, DOI 10.1136/oem.2006.032144
   Smith PM, 2009, AM J EPIDEMIOL, V170, P131, DOI 10.1093/aje/kwp147
   Stalder T, 2017, PSYCHONEUROENDOCRINO, V77, P261, DOI 10.1016/j.psyneuen.2016.12.017
   Stalder T, 2013, J CLIN ENDOCR METAB, V98, P2573, DOI 10.1210/jc.2013-1056
   Stalder T, 2012, BRAIN BEHAV IMMUN, V26, P1019, DOI 10.1016/j.bbi.2012.02.002
   Stalder T, 2012, BIOL PSYCHOL, V90, P218, DOI 10.1016/j.biopsycho.2012.03.010
   Staufenbiel SM, 2013, PSYCHONEUROENDOCRINO, V38, P1220, DOI 10.1016/j.psyneuen.2012.11.015
   Steinisch M, 2014, PSYCHONEUROENDOCRINO, V50, P20, DOI 10.1016/j.psyneuen.2014.08.001
   Steptoe A, 2004, PSYCHOSOM MED, V66, P323, DOI 10.1097/01.psy.0000126198.67070.72
   Theorell T, 2015, BMC PUBLIC HEALTH, V15, DOI 10.1186/s12889-015-1954-4
   Trudel X, 2016, INT ARCH OCC ENV HEA, V89, P1229, DOI 10.1007/s00420-016-1159-x
   Trudel X, 2016, J EPIDEMIOL COMMUN H, V70, P402, DOI 10.1136/jech-2014-204914
   Virtanen M, 2013, BMJ-BRIT MED J, V347, DOI 10.1136/bmj.f4746
   Weckesser LJ, 2014, PSYCHONEUROENDOCRINO, V46, P88, DOI 10.1016/j.psyneuen.2014.04.012
   WEITZMAN ED, 1971, J CLIN ENDOCR METAB, V33, P14, DOI 10.1210/jcem-33-1-14
   Wells S, 2014, STRESS, V17, P334, DOI 10.3109/10253890.2014.930432
   Wosu AC, 2013, ANN EPIDEMIOL, V23, P797, DOI 10.1016/j.annepidem.2013.09.006
   Wright BJ, 2011, J OCCUP ENVIRON MED, V53, P308, DOI 10.1097/JOM.0b013e31820c90b7
   Yan YX, 2016, J EPIDEMIOL, V26, P355, DOI 10.2188/jea.JE20150183
NR 58
TC 11
Z9 13
U1 0
U2 19
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1025-3890
EI 1607-8888
J9 STRESS
JI Stress
PY 2017
VL 20
IS 4
BP 363
EP 370
DI 10.1080/10253890.2017.1340452
PG 8
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA FA6TE
UT WOS:000405576300005
PM 28595512
DA 2025-06-11
ER

PT J
AU Dutt, S
   Roul, P
   Yang, YYA
   Johnson, TM
   Michaud, K
   Sauer, B
   Cannon, GW
   Baker, JF
   Curtis, JR
   Mikuls, TR
   England, BR
AF Dutt, Sarah
   Roul, Punyasha
   Yang, Yangyuna
   Johnson, Tate M.
   Michaud, Kaleb
   Sauer, Brian
   Cannon, Grant W.
   Baker, Joshua F.
   Curtis, Jeffrey R.
   Mikuls, Ted R.
   England, Bryant R.
TI Multimorbidity Patterns and Rheumatoid Arthritis Disease Outcomes:
   Findings From a Multicenter, Prospective Cohort
SO ARTHRITIS CARE & RESEARCH
LA English
DT Article
ID METABOLIC SYNDROME; REMISSION; IMPACT
AB Objective. To determine whether unique multimorbidity patterns are associated with long-term rheumatoid arthritis (RA) disease severity.
   Methods. We conducted a cohort study within the Veterans Affairs Rheumatoid Arthritis registry. We applied previously derived multimorbidity patterns based on the presence of diagnostic codes for relevant conditions prior to enrollment using linked administrative data. Disease activity and functional status were assessed longitudinally up to 5 years after enrollment. The association of multimorbidity patterns with disease activity and functional status were assessed using generalized estimating equations models adjusting for relevant confounders.
   Results. We studied 2,956 participants, of which 88.2% were male, 76.9% reported white race, and 79.3% had a smoking history. Mental health and substance abuse (beta 0.12 [95% confidence interval {CI} 0.00, 0.23]), cardiovascular (beta 0.25 [95% CI 0.12, 0.38]), and chronic pain (beta 0.21 [95% CI 0.11, 0.31]) multimorbidity were associated with higher Disease Activity Score in 28 joints (DAS28) scores. Mental health and substance abuse (beta 0.09 [0.03, 0.15]), cardiovascular (beta 0.11 [95% CI 0.04, 0.17]), and chronic pain multimorbidity (beta 0.15 [95% CI 0.10, 0.20]) were also associated with higher Multidimensional Health Assessment Questionnaire (MDHAQ) scores. The metabolic pattern of multimorbidity was not associated with DAS28 or MDHAQ. The number of multimorbidity patterns present was highly associated with DAS28 and MDHAQ (P trend < 0.001), and patients with all four multimorbidity patterns had the highest DAS28 (beta 0.59 [95% CI 0.36, 0.83]) and MDHAQ (beta 0.27 [95% CI 0.16, 0.39]) scores.
   Conclusion. Mental health and substance abuse, chronic pain, and cardiovascular multimorbidity patterns are associated with increased RA disease activity and poorer functional status. Identifying and addressing these multimorbidity patterns may facilitate achieving RA treatment targets.
C1 [Dutt, Sarah; Roul, Punyasha; Yang, Yangyuna; Johnson, Tate M.; Mikuls, Ted R.; England, Bryant R.] VA Nebraska Western Iowa Hlth Care Syst, Omaha, NE 68105 USA.
   [Dutt, Sarah; Roul, Punyasha; Yang, Yangyuna; Johnson, Tate M.; Michaud, Kaleb; Mikuls, Ted R.; England, Bryant R.] Univ Nebraska Med Ctr, Omaha, NE 68198 USA.
   [Michaud, Kaleb] FORWARD Natl Data Bank Rheumat Dis, Wichita, KS USA.
   [Sauer, Brian; Cannon, Grant W.] VA Salt Lake City, Salt Lake City, UT USA.
   [Sauer, Brian; Cannon, Grant W.] Univ Utah, Salt Lake City, UT USA.
   [Baker, Joshua F.] Corporal Michael J Crescenz VA Med Ctr, Philadelphia, PA USA.
   [Baker, Joshua F.] Univ Penn, Philadelphia, PA USA.
   [Curtis, Jeffrey R.] Univ Alabama Birmingham, Birmingham, AL USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA Nebraska-Western Iowa Health Care System; University of Nebraska
   System; University of Nebraska Medical Center; US Department of Veterans
   Affairs; Utah System of Higher Education; University of Utah; University
   of Pennsylvania; University of Alabama System; University of Alabama
   Birmingham
RP England, BR (corresponding author), VA Nebraska Western Iowa Hlth Care Syst, Omaha, NE 68105 USA.; England, BR (corresponding author), Univ Nebraska Med Ctr, Omaha, NE 68198 USA.
EM Bryant.england@unmc.edu
RI Michaud, Kaleb/AAG-3708-2020; England, Bryant/AAH-6545-2020; Curtis,
   Jeffrey/I-6723-2015; Roul, Punyasha/HJO-8788-2023; Yang,
   Yangyuna/KHW-5963-2024; Sauer, Brian/C-2548-2014
OI Sauer, Brian/0000-0002-3546-3051; Mikuls, Ted/0000-0002-0897-2272;
   Johnson, Tate/0000-0003-0335-4157; Cannon, Grant/0000-0001-6640-9173;
   Michaud, Kaleb/0000-0002-5350-3934
FU Rheumatology Research Foundation Scientist Development award; VAMerit
   Award [CX-001703]; NIH/National Institute of Arthritis and
   Musculoskeletal and Skin Diseases [P30-AR-072583]; Patient Centered
   Outcomes Research Institute; VA Merit Award [BX-004600]; Department of
   Defense [PR-200793]; NIH/National Institute of General Medical Sciences
   [IK2-CX-002203]; VA Clinical Science Research Development; 
   [U54-GM-115458]
FX Dr. Johnson's work was supported by a Rheumatology Research Foundation
   Scientist Development award. Dr. Baker's work was supported by a VAMerit
   Award (grant CX-001703). Dr. Curtis's work was supported by the
   NIH/National Institute of Arthritis and Musculoskeletal and Skin
   Diseases grant P30-AR-072583) and the Patient Centered Outcomes Research
   Institute. Dr. Mikuls's work was supported by a VA Merit Award (grant
   BX-004600), the Department of Defense (grant PR-200793) and the
   NIH/National Institute of General Medical Sciences (grant
   U54-GM-115458).Dr. England's work was supported by a Rheumatology
   Research Foundation Scientist Development award, the Great Plains
   IDeA-CTR from the NIH/National Institute of General Medical Sciences
   (grant U54-GM-115458),and the VA Clinical Science Research & Development
   (grant IK2-CX-002203).
CR Armagan B, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000009930
   ARNETT FC, 1988, ARTHRITIS RHEUM-US, V31, P315, DOI 10.1002/art.1780310302
   Barnett K, 2012, LANCET, V380, P37, DOI 10.1016/S0140-6736(12)60240-2
   Canning J, 2022, ARTHRIT CARE RES, V74, P1500, DOI 10.1002/acr.24587
   Crepaldi G, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0146991
   Crowson CS, 2023, ARTHRIT CARE RES, V75, P210, DOI 10.1002/acr.24973
   Crowson CS, 2022, RMD OPEN, V8, DOI 10.1136/rmdopen-2021-002022
   da Cunha VR, 2012, SCAND J RHEUMATOL, V41, P186, DOI 10.3109/03009742.2011.626443
   Duffield SJ, 2018, RHEUMATOLOGY, V57, P1453, DOI 10.1093/rheumatology/key112
   England BR., 2021, ARTHRITIS CARE RES H, V75, P231
   England BR, 2023, ARTHRIT CARE RES, V75, P220, DOI 10.1002/acr.24956
   England BR, 2021, ANN RHEUM DIS, V80, P286, DOI 10.1136/annrheumdis-2020-218282
   England BR, 2020, CURR OPIN RHEUMATOL, V32, P255, DOI 10.1097/BOR.0000000000000703
   England BR, 2018, CLIN RHEUMATOL, V37, P2907, DOI 10.1007/s10067-018-4314-9
   England BR, 2018, BMJ-BRIT MED J, V361, DOI 10.1136/bmj.k1036
   FELSON DT, 1993, ARTHRITIS RHEUM-US, V36, P729, DOI 10.1002/art.1780360601
   George MD, 2019, J RHEUMATOL, V46, P343, DOI 10.3899/jrheum.180178
   Karvounaris SA, 2007, ANN RHEUM DIS, V66, P28, DOI 10.1136/ard.2006.053488
   Lee YC, 2016, RHEUMATOLOGY, V55, P640, DOI 10.1093/rheumatology/kev388
   Liu Y, 2017, ARTHRIT CARE RES, V69, P157, DOI 10.1002/acr.22932
   Maloley PM, 2019, SEMIN ARTHRITIS RHEU, V49, P229, DOI 10.1016/j.semarthrit.2019.02.002
   Matcham F, 2016, BMC MUSCULOSKEL DIS, V17, DOI 10.1186/s12891-016-1011-1
   Michelsen B, 2017, ANN RHEUM DIS, V76, P1906, DOI 10.1136/annrheumdis-2017-211284
   Mikuls Ted R, 2015, Fed Pract, V32, P24
   Mikuls TR, 2013, ARTHRIT CARE RES, V65, P227, DOI 10.1002/acr.21778
   Miriovsky BJ, 2010, ANN RHEUM DIS, V69, P1292, DOI 10.1136/ard.2009.122739
   Prados-Torres A, 2014, J CLIN EPIDEMIOL, V67, P254, DOI 10.1016/j.jclinepi.2013.09.021
   Radner H, 2015, RHEUMATOLOGY, V54, P2076, DOI 10.1093/rheumatology/kev239
   Radner H, 2015, J RHEUMATOL, V42, P1099, DOI 10.3899/jrheum.141534
   Spagnolo P, 2018, ARTHRITIS RHEUMATOL, V70, P1544, DOI 10.1002/art.40574
NR 30
TC 4
Z9 4
U1 2
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2151-464X
EI 2151-4658
J9 ARTHRIT CARE RES
JI Arthritis Care Res.
PD MAR
PY 2025
VL 77
IS 3
BP 337
EP 348
DI 10.1002/acr.25184
EA OCT 2023
PG 12
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 1OW3O
UT WOS:001094022800001
PM 37394710
OA hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Cruthirds, CL
   van der Meij, BS
   Wierzchowska-McNew, A
   Deutz, NEP
   Engelen, MPKJ
AF Cruthirds, Clayton L.
   van der Meij, Barbara S.
   Wierzchowska-McNew, Agata
   Deutz, Nicolaas E. P.
   Engelen, Marielle P. K. J.
TI Presence or Absence of Skeletal Muscle Dysfunction in Chronic
   Obstructive Pulmonary Disease is Associated With Distinct Phenotypes
SO ARCHIVOS DE BRONCONEUMOLOGIA
LA English
DT Article
DE COPD; Muscle strength; Cognition; Phenotype; Metabolism
ID COGNITIVE FUNCTION; SYSTEMIC INFLAMMATION; OXIDATIVE STRESS; STRENGTH;
   REHABILITATION; IMPAIRMENT; METABOLISM; EXERCISE; DECLINE; UPDATE
AB Introduction: Reduced skeletal muscle function and cognitive performance are common extrapulmonary features in Chronic Obstructive Pulmonary Disease (COPD) but their connection remains unclear. Whether presence or absence of skeletal muscle dysfunction in COPD patients is linked to a specific phenotype consisting of reduced cognitive performance, comorbidities and nutritional and metabolic disturbances needs further investigation.
   Methods: Thirty-seven patients with COPD (grade II-IV) were divided into two phenotypic cohorts based on the presence (COPD dysfunctional, n = 25) or absence (COPD functional, n = 12) of muscle dysfunction. These cohorts were compared to 28 healthy, age matched controls. Muscle strength (dynamometry), cognitive performance (Trail Making Test and STROOP Test), body composition (Dual-energy X-Ray Absorptiometry), habitual physical activity, comorbidities and mood status (questionnaires) were measured. Pulse administration of stable amino acid tracers was performed to measure whole body production rates.
   Results: Presence of muscle dysfunction in COPD was independent of muscle mass or severity of airflow obstruction but associated with impaired STROOP Test performance (p = 0.04), reduced resting O-2 saturation (p = 0.003) and physical inactivity (p = 0.01), and specific amino acid metabolic disturbances (enhanced leucine (p = 0.02) and arginine (p = 0.06) production). In contrast, COPD patients with normal muscle function presented with anxiety, increased fat mass, plasma glucose concentration, and metabolic syndrome related comorbidities (hypertension and dyslipidemia).
   Conclusion: COPD patients with muscle dysfunction show characteristics of a cognitive metabolic impairment phenotype, influenced by the presence of hypoxia, whereas those with normal muscle function present a phenotype of metabolic syndrome and mood disturbances.
   (C) 2020 SEPAR. Published by Elsevier Espanna, S.L.U. All rights reserved.
C1 [Cruthirds, Clayton L.; van der Meij, Barbara S.; Wierzchowska-McNew, Agata; Deutz, Nicolaas E. P.; Engelen, Marielle P. K. J.] Texas A&M Univ, Ctr Translat Res Aging & Longev, Dept Hlth & Kinesiol, College Stn, TX 77843 USA.
   [van der Meij, Barbara S.] Bond Univ, Nutr & Dietet Res Grp, Fac Hlth Sci & Med, Gold Coast, Qld, Australia.
   [van der Meij, Barbara S.] Mater Grp, Dietet & Foodserv, Brisbane, Qld, Australia.
   [van der Meij, Barbara S.] Univ Queensland, Mater Res Inst, Brisbane, Qld, Australia.
C3 Texas A&M University System; Texas A&M University College Station; Bond
   University; University of Queensland; Mater Research
RP Engelen, MPKJ (corresponding author), Texas A&M Univ, Ctr Translat Res Aging & Longev, Dept Hlth & Kinesiol, College Stn, TX 77843 USA.
EM mpkj.engelen@ctral.org
RI van der Meij, Barbara/ABD-1824-2020; Deutz, Nicolaas/J-5200-2012
OI McNew, Raven A/0000-0003-2374-1664
CR Alfaro-Acha A, 2006, J GERONTOL A-BIOL, V61, P859, DOI 10.1093/gerona/61.8.859
   Baierle M, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/804198
   Barreiro E, 2016, CHRON RESP DIS, V13, P297, DOI 10.1177/1479972316642366
   Barreiro E, 2015, COPD, V12, P413, DOI 10.3109/15412555.2014.974737
   Burgel PR, 2017, EUR RESPIR J, V50, DOI 10.1183/13993003.01034-2017
   Cleutjens FAHM, 2017, J AM MED DIR ASSOC, V18, P420, DOI 10.1016/j.jamda.2016.11.016
   Coimbra-Costa D, 2017, REDOX BIOL, V12, P216, DOI 10.1016/j.redox.2017.02.014
   Dag E, 2016, RESP CARE, V61, P1044, DOI 10.4187/respcare.04403
   Dal Negro R W, 2012, Monaldi Arch Chest Dis, V77, P67
   Degens H, 2010, SCAND J MED SCI SPOR, V20, P28, DOI 10.1111/j.1600-0838.2009.01018.x
   Deutz NEP, 2018, METABOLISM, V78, P167, DOI 10.1016/j.metabol.2017.09.015
   Divo MJ, 2015, EUR RESPIR J, V46, P640, DOI 10.1183/09031936.00171614
   Engelen MPKJ, 2012, CLIN NUTR, V31, P616, DOI 10.1016/j.clnu.2012.04.006
   Engelen MPKJ, 2001, AM J RESP CRIT CARE, V163, P859, DOI 10.1164/ajrccm.163.4.2006137
   Gea J, 2015, J THORAC DIS, V7, pE418, DOI 10.3978/j.issn.2072-1439.2015.08.04
   Gosker HR, 2019, J CLIN MED, V8, DOI 10.3390/jcm8070915
   Jaitovich A, 2018, AM J RESP CRIT CARE, V198, P175, DOI 10.1164/rccm.201710-2140CI
   Jonker R, 2016, AM J CLIN NUTR, V103, P1458, DOI 10.3945/ajcn.115.125187
   Karamanli H, 2015, INT J CHRONIC OBSTR, V10, P2087, DOI 10.2147/COPD.S88326
   Kim HC, 2010, TUBERC RESPIR DIS, V68, P125, DOI 10.4046/trd.2010.68.3.125
   Langen RCJ, 2004, FASEB J, V18, P227, DOI 10.1096/fj.03-0251com
   Lieben CK, 2018, CLIN NUTR, V37, P321, DOI 10.1016/j.clnu.2016.12.029
   Teixeira CVL, 2013, PSYCHOGERIATRICS, V13, P148, DOI 10.1111/psyg.12017
   Lipovec NC, 2016, COPD, V13, P399, DOI 10.3109/15412555.2016.1140732
   Maltais F, 2014, AM J RESP CRIT CARE, V189, P1121, DOI 10.1164/rccrn.201402-0373ST
   Miravitlles M, 2014, LUNG, V192, P259, DOI 10.1007/s00408-014-9557-x
   Ouellette DR, 2017, INT J CHRONIC OBSTR, V12, P639, DOI 10.2147/COPD.S123994
   Pelgrim CE, 2019, EUR J PHARMACOL, V842, P99, DOI 10.1016/j.ejphar.2018.10.001
   Pereira EDB, 2011, LUNG, V189, P279, DOI 10.1007/s00408-011-9303-6
   Plassman BL, 2010, ANN INTERN MED, V153, P182, DOI 10.7326/0003-4819-153-3-201008030-00258
   Raji MA, 2005, J AM GERIATR SOC, V53, P1462, DOI 10.1111/j.1532-5415.2005.53457.x
   Rosano C, 2005, NEUROEPIDEMIOLOGY, V24, P8, DOI 10.1159/000081043
   Ryu CW, 2013, COPD, V10, P357, DOI 10.3109/15412555.2012.752808
   Schure MB, 2016, RESP MED, V114, P46, DOI 10.1016/j.rmed.2016.03.005
   Solvang SEH, 2019, BRAIN BEHAV IMMUN, V75, P155, DOI 10.1016/j.bbi.2018.10.003
   Swallow EB, 2007, THORAX, V62, P115, DOI 10.1136/thx.2006.062026
   Takabatake N, 2000, AM J RESP CRIT CARE, V161, P1179, DOI 10.1164/ajrccm.161.4.9903022
   Thakur Neeta, 2010, Int J Chron Obstruct Pulmon Dis, V5, P263
   Vanfleteren LEGW, 2013, AM J RESP CRIT CARE, V187, P728, DOI 10.1164/rccm.201209-1665OC
   Wiegman CH, 2015, J ALLERGY CLIN IMMUN, V136, P769, DOI 10.1016/j.jaci.2015.01.046
NR 40
TC 15
Z9 16
U1 0
U2 23
PU ELSEVIER ESPANA SLU
PI BARCELONA
PA AV JOSEP TARRADELLAS, 20-30, 1ERA PLANTA, BARCELONA, CP-08029, SPAIN
SN 0300-2896
EI 1579-2129
J9 ARCH BRONCONEUMOL
JI Arch. Bronconeumol.
PD APR
PY 2021
VL 57
IS 4
BP 264
EP 272
DI 10.1016/j.arbres.2019.12.034
EA APR 2021
PG 9
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA RP3CI
UT WOS:000641609500009
PM 32115277
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Ajiboye, TO
   Aliyu, H
   Tanimu, MA
   Muhammad, RM
   Ibitoye, OB
AF Ajiboye, T. O.
   Aliyu, H.
   Tanimu, M. A.
   Muhammad, R. M.
   Ibitoye, O. B.
TI Dioscoreophyllum cumminsii (Stapf) Diels leaves halt
   high-fructose induced metabolic syndrome: Hyperglycemia, insulin
   resistance, inflammation and oxidative stress
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Dioscoreophyllum cumminsii; Insulin resistance; Dyslipidemia;
   High-fructose diet; Metabolic syndrome; Inflammation; Oxidative stress
ID ADIPOSE-TISSUE; ANTIOXIDANT; CHOLESTEROL; SENSITIVITY; EXPRESSION;
   EXTRACT; ENZYME
AB Ethnopharmacological relevance: Dioscoreophyllum cumminsii is widely used in the management and treatment of diabetes and obesity in Nigeria. This study evaluates the effect of aqueous leaf extract of D. cumminsii on high-fructose diet-induced metabolic syndrome.
   Methods: Seventy male rats were randomized into seven groups. All rats were fed with high-fructose diet for 9 weeks except groups A and C rats, which received control diet. In addition to the diet treatment, groups A and B rats received distilled water for 3 weeks starting from the seventh week of the experimental period. Rats in groups C-F orally received 400, 100, 200 and 400 mg/kg body weight of aqueous leaf extract of D. cumminsii respectively, while group G received 300 mg/kg bodyweight of metformin for 3 weeks starting from the seventh week.
   Results: There was significant (p < 0.05) reduction in high-fructose diet-mediated increase in body weight, body mass index, abdominal circumference, blood glucose, insulin, leptin and insulin resistance by aqueous leaf extract of D. cumminsii. Conversely, high-fructose diet-mediated decrease in adiponectin was reversed by the extract. Increased levels of cholesterol, triglycerides, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, atherogenic index, cardiac index and coronary artery index were significantly lowered by the extract, while high-fructose diet mediated decrease in high density lipoprotein cholesterol was increased by the extract. Tumour necrosis factor-alpha, interleukin-6 and interleukin-8 levels increased significantly in high-fructose diet-fed rats, which were significantly reversed by the extract. High-fructose mediated-decrease in superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glucose 6-phosphate dehydrogenase and glutathione reduced were significantly reversed by aqueous leaf extract of D. cumminsii. Conversely, elevated levels of malondialdehyde, conjugated dienes, lipid hydroperoxides, protein carbonyl and fragmented DNA were significantly lowered by the extract.
   Conclusion: Data generated in this study further laid credence to the hypoglycemic activity of aqueous leaf extract of D. cumminsii as evident from the reversal of hyperglycemia, insulin resistance, dyslipidemia, inflammation and oxidative stress in high-fructose diet-induced metabolic syndrome rats. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Ajiboye, T. O.; Aliyu, H.; Tanimu, M. A.; Muhammad, R. M.; Ibitoye, O. B.] Al Hikmah Univ, Dept Biol Sci, Antioxidants Free Radicals Funct Foods & Toxicol, Ilorin, Nigeria.
RP Ajiboye, TO (corresponding author), Al Hikmah Univ, Dept Biol Sci, Antioxidants Free Radicals Funct Foods & Toxicol, Ilorin, Nigeria.
EM ajiboyeyong@yahoo.com
RI Ajiboye, Taofeek/H-5383-2011
CR AEBI H, 1984, METHOD ENZYMOL, V105, P121
   Ajboye TO, 2010, PHARM BIOL, V48, P1361, DOI 10.3109/13880209.2010.483247
   Ajiboye T.O., 2015, J SCI FOOD AGR
   Ajiboye TO, 2014, J BIOCHEM MOL TOXIC, V28, P11, DOI 10.1002/jbt.21517
   Ajiboye TO, 2010, DRUG CHEM TOXICOL, V33, P77, DOI 10.3109/01480540903170746
   Ajiboye TO, 2011, HUM EXP TOXICOL, V30, P55, DOI 10.1177/0960327110366785
   [Anonymous], 2011, Guide for the Care and Use of Laboratory Animals, VEighth, DOI DOI 10.2307/1525495
   Awazawa M, 2011, CELL METAB, V13, P401, DOI 10.1016/j.cmet.2011.02.010
   Aydin S, 2014, NUTRITION, V30, P1, DOI 10.1016/j.nut.2013.05.013
   Bettaieb A, 2014, FREE RADICAL BIO MED, V72, P247, DOI 10.1016/j.freeradbiomed.2014.04.011
   BURTON K, 1956, BIOCHEM J, V62, P315, DOI 10.1042/bj0620315
   Chen KN, 2013, J FOOD DRUG ANAL, V21, P347, DOI 10.1016/j.jfda.2013.08.001
   Chen Q, 2011, J LIPID RES, V52, P801, DOI 10.1194/jlr.M012963
   Das UN, 2015, NUTRITION, V31, P249, DOI 10.1016/j.nut.2014.05.015
   ELLMAN GL, 1959, ARCH BIOCHEM BIOPHYS, V82, P70, DOI 10.1016/0003-9861(59)90090-6
   Fernandez-Sanchez A., 2011, Int J Mol Sci
   Fonseca-Alaniz MH, 2007, J PEDIAT-BRAZIL, V83, pS192, DOI [10.1590/S0021-75572007000700011, 10.2223/JPED.1709]
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Han TS, 2010, MEDICINE, V39, P24
   Harborne J., 2009, PLANTA MED, V33, P217
   HISSIN PJ, 1976, ANAL BIOCHEM, V74, P214, DOI 10.1016/0003-2697(76)90326-2
   Ibrahim MA, 2014, EUR J PHARMACOL, V724, P204, DOI 10.1016/j.ejphar.2013.12.024
   Kang MJ, 2004, CLIN CHIM ACTA, V350, P79, DOI 10.1016/j.cccn.2004.07.005
   KAYAMORI F, 1994, BIOSCI BIOTECH BIOCH, V58, P570, DOI 10.1271/bbb.58.570
   Ko BJ, 2014, METABOLISM, V63, P168, DOI 10.1016/j.metabol.2013.11.004
   LEVINE RL, 1990, METHOD ENZYMOL, V186, P464
   Marek G, 2015, DIABETES, V64, P508, DOI 10.2337/db14-0411
   MISRA HP, 1972, J BIOL CHEM, V247, P3170
   Mohammadi A, 2014, IRAN J BASIC MED SCI, V17, P263
   Musi N, 2014, CELLULAR ENDOCRINOLOGY IN HEALTH AND DISEASE, P229, DOI 10.1016/B978-0-12-408134-5.00014-7
   Novelli ELB, 2007, LAB ANIM-UK, V41, P111, DOI 10.1258/002367707779399518
   Oliver-Bever B., 1986, Medicinal plants in tropical West Africa
   Oloyede HOB, 2015, J ETHNOPHARMACOL, V166, P313, DOI 10.1016/j.jep.2015.02.049
   Oloyede H. O. B., 2013, Food Bioscience, V1, P48
   Oloyede OB, 2014, J ETHNOPHARMACOL, V157, P309, DOI 10.1016/j.jep.2014.08.022
   Oron-Herman M, 2008, AM J HYPERTENS, V21, P1018, DOI 10.1038/ajh.2008.218
   Panchal SK, 2012, NUTRITION, V28, P1055, DOI 10.1016/j.nut.2012.02.013
   Prakash P, 2014, EUR J PHARMACOL, V727, P15, DOI 10.1016/j.ejphar.2014.01.038
   Rabie EM, 2015, EUR J PHARMACOL, V760, P145, DOI 10.1016/j.ejphar.2015.04.019
   Reilly C A, 2001, Curr Protoc Toxicol, VChapter 2, DOI 10.1002/0471140856.tx0204s00
   Samson S.L., 2014, ENDOCRINOL METAB CLI
   Scarpace PJ, 2009, AM J PHYSIOL-REG I, V296, pR493, DOI 10.1152/ajpregu.90669.2008
   Singh P, 2012, CIRC RES, V111, P599, DOI [10.1161/circresaha.112.273656, 10.1161/CIRCRESAHA.112.273656]
   Troupin G, 1962, MONOGRAPHIE MENISPER
   Velickovic N, 2013, BRIT J NUTR, V110, P456, DOI 10.1017/S0007114512005193
   Vickers Andrew J, 2007, J Soc Integr Oncol, V5, P125, DOI 10.2310/7200.2007.011
   Wang O, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0118135
NR 47
TC 25
Z9 25
U1 0
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD NOV 4
PY 2016
VL 192
BP 471
EP 479
DI 10.1016/j.jep.2016.08.024
PG 9
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA EB2LF
UT WOS:000387193000048
PM 27568876
DA 2025-06-11
ER

PT J
AU Urquiaga, I
   D'Acuña, S
   Pérez, D
   Dicenta, S
   Echeverría, G
   Rigotti, A
   Leighton, F
AF Urquiaga, Ines
   D'Acuna, Sonia
   Perez, Druso
   Dicenta, Sara
   Echeverria, Guadalupe
   Rigotti, Attilio
   Leighton, Federico
TI Wine grape pomace flour improves blood pressure, fasting glucose and
   protein damage in humans: a randomized controlled trial
SO BIOLOGICAL RESEARCH
LA English
DT Article
DE Antioxidant; Dietary intervention; Fiber; Metabolic syndrome; Oxidative
   stress; Wine grape pomace
ID POSTPRANDIAL OXIDATIVE STRESS; PLASMA ANTIOXIDANT CAPACITY;
   CORONARY-HEART-DISEASE; DIETARY FIBER INTAKE; RED WINE;
   CARDIOVASCULAR-DISEASE; COLONIC FERMENTATION; MEDITERRANEAN DIET;
   METAANALYSIS; INDIVIDUALS
AB Background: The Mediterranean diet is a healthy diet with positive scientific evidence of preventing chronic diseases. Bioactive components support the healthy properties of the Mediterranean diet. Antioxidants and fiber, two components of the Mediterranean diet, are key functional nutrients for healthy eating and nutrition. Wine grape pomace is a rich source of these dietary constituents and may be beneficial for human health. Our hypothesis was that the intake of red wine grape pomace flour (WGPF) prepared from red wine grapes (Cabernet Sauvignon variety) reduced the metabolic syndrome in humans. To evaluate the effect of WGPF on components of metabolic syndrome we design a 16-week longitudinal intervention study. Thirty-eight males, 30-65 years of age, with at least one component of metabolic syndrome, were randomly assigned to either the intervention group (n = 25) or the control group (n = 13). At lunch, the intervention group was given 20 g of WGPF per day, which contained 10 g of dietary fiber, 822 mg of polyphenols and an antioxidant capacity of 7258 ORAC units. Both groups were asked to maintain their regular eating habits and lifestyles. Clinical evaluation, anthropometric measurements and biochemical blood analyses were done at the beginning and the end of the study.
   Results: WGPF intake significantly decreased systolic and diastolic blood pressure as well as fasting glucose levels. Plasma.-tocopherol and d-tocopherol increased and carbonyl group in plasma protein decreased in WGPT group, significantly. No significant effect was observed for waist circumference, HDL cholesterol, triglycerides, total antioxidant capacity and vitamin C in and between groups. The group-dependent magnitude of the differences between the baseline and final postprandial insulin values and.-tocopherol concentrations was statistically significant.
   Conclusions: The consumption of WGPF-rich in fiber and polyphenol antioxidants, as a food supplement in a regular diet improves blood pressure, glycaemia and postprandial insulin. In addition, increased antioxidant defenses and decreased oxidative protein damage indicating attenuation of oxidative stress. WGPF might be a useful food ingredient for health promotion and chronic disease prevention.
C1 [Urquiaga, Ines; D'Acuna, Sonia; Perez, Druso; Dicenta, Sara; Echeverria, Guadalupe; Rigotti, Attilio; Leighton, Federico] Pontificia Univ Catolica Chile, Ctr Nutr Mol & Enfermedades Cron, Fac Med, Santiago, Chile.
   [Rigotti, Attilio] Pontificia Univ Catolica Chile, Dept Nutr Diabet & Metab, Escuela Med, Santiago, Chile.
C3 Pontificia Universidad Catolica de Chile; Pontificia Universidad
   Catolica de Chile
RP Urquiaga, I (corresponding author), Pontificia Univ Catolica Chile, Ctr Nutr Mol & Enfermedades Cron, Fac Med, Ave Libertador Bernardo OHiggins 340, Santiago, Chile.
EM iurquiaga@bio.puc.cl
RI Echeverría, Guadalupe/GWV-3832-2022
OI Echeverria, Guadalupe/0000-0002-2915-0171
FU FONDEF (Chile) [AF10i1014]
FX Supported by a grant from FONDEF AF10i1014 (Chile).
CR Anderson JW, 2004, J AM COLL NUTR, V23, P5, DOI 10.1080/07315724.2004.10719338
   Anderson RA, 2001, ATHEROSCLEROSIS, V154, P475, DOI 10.1016/S0021-9150(00)00499-8
   Bazzano LA, 2003, ARCH INTERN MED, V163, P1897, DOI 10.1001/archinte.163.16.1897
   Bloomer RJ, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-79
   Botero D, 2009, OBESITY, V17, P1664, DOI 10.1038/oby.2009.203
   BRAVO L, 1994, BRIT J NUTR, V71, P933, DOI 10.1079/BJN19940197
   Burton-Freeman B, 2010, BRIT J NUTR, V104, pS1, DOI 10.1017/S0007114510003909
   Cardona F, 2008, EUR J CLIN INVEST, V38, P510, DOI 10.1111/j.1365-2362.2008.01959.x
   Ceriello A, 2004, DIABETES, V53, P701, DOI 10.2337/diabetes.53.3.701
   Dohadwala MM, 2009, J NUTR, V139, p1788S, DOI 10.3945/jn.109.107474
   Estruch R, 2013, NEW ENGL J MED, V368, P1279, DOI 10.1056/NEJMoa1200303
   Fisher-Wellman KH, 2010, J AM COLL NUTR, V29, P373, DOI 10.1080/07315724.2010.10719854
   Giacco R, 2014, NUTR METAB CARDIOVAS, V24, P837, DOI 10.1016/j.numecd.2014.01.007
   Gorelik S, 2008, FASEB J, V22, P41, DOI 10.1096/fj.07-9041com
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Halliwell B, 1997, NUTR REV, V55, pS44, DOI 10.1111/j.1753-4887.1997.tb06100.x
   Huang DJ, 2002, J AGR FOOD CHEM, V50, P4437, DOI 10.1021/jf0201529
   Jiang Q, 2014, FREE RADICAL BIO MED, V72, P76, DOI 10.1016/j.freeradbiomed.2014.03.035
   Kanner J, 2012, J AGR FOOD CHEM, V60, P8790, DOI 10.1021/jf300193g
   KEYS A, 1970, CIRCULATION, V41, pI1
   Kim H, 2014, J AGR FOOD CHEM, V62, P1919, DOI 10.1021/jf404832s
   Kimoto E, 1997, METHOD ENZYMOL, V279, P3
   Leighton F, 2006, CELL BIOCHEM FUNCT, V24, P291, DOI 10.1002/cbf.1269
   Leighton F, 2009, PUBLIC HEALTH NUTR, V12, P1635, DOI 10.1017/S1368980009990486
   LEVINE RL, 1994, METHOD ENZYMOL, V233, P346
   MOTCHNIK PA, 1994, METHOD ENZYMOL, V234, P269
   Natella F, 2011, BRIT J NUTR, V105, P1718, DOI 10.1017/S0007114510005544
   O'Keefe JH, 2008, J AM COLL CARDIOL, V51, P249, DOI 10.1016/j.jacc.2007.10.016
   Pérez-Jiménez J, 2008, NUTR RES REV, V21, P158, DOI 10.1017/S0954422408125124
   Pérez-Jiménez J, 2008, NUTRITION, V24, P646, DOI 10.1016/j.nut.2008.03.012
   Perez-Jimenez J, 2009, PLANT FOOD HUM NUTR, V64, P102, DOI 10.1007/s11130-009-0110-7
   Pickering Thomas G, 2005, J Clin Hypertens (Greenwich), V7, P102, DOI 10.1111/j.1524-6175.2005.04377.x
   Pisoschi AM, 2009, MOLECULES, V14, P480, DOI 10.3390/molecules14010480
   Satija A, 2012, CURR ATHEROSCLER REP, V14, P505, DOI 10.1007/s11883-012-0275-7
   Saura-Calixto F, 2000, J AGR FOOD CHEM, V48, P3342, DOI 10.1021/jf0000373
   Saura-Calixto F., 1998, J AGR FOOD CHEM, V46, P4
   Saura-Calixto F, 2011, J AGR FOOD CHEM, V59, P43, DOI 10.1021/jf1036596
   Saura-Calixto F, 2010, MOL NUTR FOOD RES, V54, P939, DOI 10.1002/mnfr.200900276
   Serafini M, 1998, J NUTR, V128, P1003, DOI 10.1093/jn/128.6.1003
   Silva FM, 2013, NUTR REV, V71, P790, DOI 10.1111/nure.12076
   Simopoulos AP, 2001, J NUTR, V131, p3065S, DOI 10.1093/jn/131.11.3065S
   Slavin J, 2003, P NUTR SOC, V62, P129, DOI 10.1079/PNS2002221
   Streppel MT, 2008, AM J CLIN NUTR, V88, P1119, DOI 10.1093/ajcn/88.4.1119
   Streppel MT, 2005, ARCH INTERN MED, V165, P150, DOI 10.1001/archinte.165.2.150
   TEBIB K, 1994, J NUTR, V124, P2451, DOI 10.1093/jn/124.12.2451
   Trichopoulou A, 2004, PUBLIC HEALTH NUTR, V7, P943, DOI 10.1079/PHN2004558
   Tsang C, 2005, BRIT J NUTR, V94, P170, DOI 10.1079/BJN20051480
   Urquiaga I, 2004, BIOL RES, V37, P253
   Urquiaga JS, 2005, WORLD REV NUTR DIET, V95, P122, DOI 10.1159/000088299
   WAYNER DDM, 1985, FEBS LETT, V187, P33, DOI 10.1016/0014-5793(85)81208-4
   WHO, 2004, PUBLIC HLTH NU S1001, V7
NR 51
TC 88
Z9 93
U1 0
U2 78
PU SOC BIOLGIA CHILE
PI SANTIAGO
PA CASILLA 16164, SANTIAGO 9, CHILE
SN 0716-9760
EI 0717-6287
J9 BIOL RES
JI Biol. Res.
PD SEP 4
PY 2015
VL 48
AR 49
DI 10.1186/s40659-015-0040-9
PG 10
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA CQ4XU
UT WOS:000360608700001
PM 26337448
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zou, XH
   Sun, Y
AF Zou, Xiaohan
   Sun, Yuan
TI Bibliometrics Analysis of the Research Status and Trends of the
   Association Between Depression and Insulin From 2010 to 2020
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE insulin; depression; sex hormones; bibliometric analysis; citespace
ID POLYCYSTIC-OVARY-SYNDROME; TESTOSTERONE LEVELS; MICE MODULATION;
   MESSENGER-RNA; ER-ALPHA; RESISTANCE; RECEPTOR; BRAIN; ESTROGEN; EXERCISE
AB Depression is one of the common mental illnesses. Because it is an important complication of diabetes, its association with changes in insulin levels and insulin resistance, the causative factors of diabetes, has attracted widespread attention. However, the association between insulin and depression has not been systematically studied through bibliometric and visual analysis. This study is based on 3131 publications of Web of Science to identify the current research status and research trends in this field. The results show that since 2010, the number of publications has been growing rapidly. Cooperative network analysis shows that the United States, the University of Toronto and Roger S Mcintyre are the most influential countries, research institutes and scholars, respectively. Insulin resistance, obesity, and metabolic syndrome are hot topics in this field. Analysis of keywords and references reveals that "sex hormones, " is new research area that constantly emerging. As far as we know, this study is the first one to visualize the association between depression and insulin and predict potential future research trends through bibliometric and visual analysis.
C1 [Zou, Xiaohan] Jilin Univ, Jilin Prov Key Lab Mol & Chem Genet, Hosp 2, Changchun, Peoples R China.
   [Sun, Yuan] Jilin Univ, Publ Comp Educ & Res Ctr, Changchun, Peoples R China.
C3 Jilin University; Jilin University
RP Sun, Y (corresponding author), Jilin Univ, Publ Comp Educ & Res Ctr, Changchun, Peoples R China.
EM sy@jlu.edu.cn
FU Jilin University
FX This work was supported by Jilin University.
CR Ahola AJ, 2021, DIABETES CARE, V44, P174, DOI 10.2337/dc20-0493
   Archer T, 2014, CNS NEUROL DISORD-DR, V13, P1640
   Barros RPA, 2009, AM J PHYSIOL-ENDOC M, V297, pE124, DOI 10.1152/ajpendo.00189.2009
   Bianchi R, 2017, NEUROSCI BIOBEHAV R, V83, P238, DOI 10.1016/j.neubiorev.2017.10.019
   Blumenthal JA, 2007, PSYCHOSOM MED, V69, P587, DOI 10.1097/PSY.0b013e318148c19a
   Booth FW, 2012, COMPR PHYSIOL, V2, P1143, DOI 10.1002/cphy.c110025
   CANGIANO C, 1983, BIOCHEM INT, V7, P617
   Catteau-Jonard S, 2013, FRONT HORM RES, V40, P22, DOI 10.1159/000341679
   Chabot JG, 1996, HISTOCHEM J, V28, P729, DOI 10.1007/BF02272147
   Chen CM, 2018, CHIIR'18: PROCEEDINGS OF THE 2018 CONFERENCE ON HUMAN INFORMATION INTERACTION & RETRIEVAL, P369, DOI 10.1145/3176349.3176897
   Chen CM, 2017, J DATA INFO SCI, V2, P1, DOI 10.1515/jdis-2017-0006
   Chen CM, 2010, J AM SOC INF SCI TEC, V61, P1386, DOI 10.1002/asi.21309
   Chen CM, 2004, P NATL ACAD SCI USA, V101, P5303, DOI 10.1073/pnas.0307513100
   Chen CM, 2004, SCIENTOMETRICS, V59, P199, DOI 10.1023/B:SCIE.0000018528.59913.48
   Chen HB, 2014, INT J LIFE CYCLE ASS, V19, P1674, DOI 10.1007/s11367-014-0777-3
   Correa M, 2020, BEHAV PHARMACOL, V31, P553, DOI 10.1097/FBP.0000000000000556
   DECASTRO JM, 1985, PHARMACOL BIOCHEM BE, V23, P495, DOI 10.1016/0091-3057(85)90407-1
   Duclos M, 2016, FRONT HORM RES, V47, P12, DOI 10.1159/000445149
   DUNAIF A, 1989, DIABETES, V38, P1165, DOI 10.2337/diabetes.38.9.1165
   Dunaif A, 1997, ENDOCR REV, V18, P774, DOI 10.1210/er.18.6.774
   Fan YZ, 2021, PHYSIOL BEHAV, V233, DOI 10.1016/j.physbeh.2021.113353
   FIGLEWICZ DP, 1994, BRAIN RES, V644, P331, DOI 10.1016/0006-8993(94)91698-5
   Fullman N, 2017, LANCET, V390, P1423, DOI [10.1016/S0140-6736(18)30994-2, 10.1016/s0140-6736(18)30994-2]
   Gettler LT, 2016, SOC SCI MED, V163, P157, DOI 10.1016/j.socscimed.2016.06.044
   Gold PW, 2021, TRENDS ENDOCRIN MET, V32, P212, DOI 10.1016/j.tem.2021.01.003
   Greenwood BN, 2005, BIOL PSYCHIAT, V57, P559, DOI 10.1016/j.biopsych.2004.11.025
   Greenwood EA, 2018, FERTIL STERIL, V109, pE7, DOI 10.1016/j.fertnstert.2018.02.024
   Grillo CA, 2011, BEHAV BRAIN RES, V222, P230, DOI 10.1016/j.bbr.2011.03.052
   Gupta D, 2016, BEHAV BRAIN RES, V297, P41, DOI 10.1016/j.bbr.2015.10.007
   Gupta D, 2014, PHYSIOL BEHAV, V129, P73, DOI 10.1016/j.physbeh.2014.02.036
   Gupte AA, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/916585
   HALBREICH U, 1995, BIOL PSYCHIAT, V37, P434, DOI 10.1016/0006-3223(94)00181-2
   HALBREICH U, 1995, J PSYCHIATR RES, V29, P153, DOI 10.1016/0022-3956(95)00005-P
   HALBREICH U, 1995, ARCH GEN PSYCHIAT, V52, P606
   Hamer JA, 2019, EXP NEUROL, V315, P1, DOI 10.1016/j.expneurol.2019.01.016
   Hannon TS, 2014, PEDIATR OBES, V9, pE103, DOI 10.1111/ijpo.237
   Hollinrake E, 2007, FERTIL STERIL, V87, P1369, DOI 10.1016/j.fertnstert.2006.11.039
   Ignácio ZM, 2019, MOL NEUROBIOL, V56, P8323, DOI 10.1007/s12035-019-01670-1
   Janssen I, 2010, INT J BEHAV NUTR PHY, V7, DOI 10.1186/1479-5868-7-40
   Jovanovic H, 2015, NEUROIMAGE, V106, P47, DOI 10.1016/j.neuroimage.2014.11.003
   Karim R, 2009, J CLIN ENDOCR METAB, V94, P4136, DOI 10.1210/jc.2009-0643
   Kleinridders A, 2014, DIABETES, V63, P2232, DOI 10.2337/db14-0568
   Leonard BE, 2020, ACTA NEUROPSYCHIATR, V32, P1, DOI 10.1017/neu.2019.17
   Malhi GS, 2018, LANCET, V392, P2299, DOI 10.1016/S0140-6736(18)31948-2
   McEwen B, 2001, P NATL ACAD SCI USA, V98, P7093, DOI 10.1073/pnas.121146898
   Miller GE, 2008, BIOL PSYCHIAT, V64, P266, DOI 10.1016/j.biopsych.2008.03.017
   Moulton CD, 2015, LANCET DIABETES ENDO, V3, P461, DOI 10.1016/S2213-8587(15)00134-5
   Nead KT, 2019, CURR OPIN ENDOCRINOL, V26, P175, DOI 10.1097/MED.0000000000000477
   Olive LS, 2017, HEALTH PSYCHOL, V36, P749, DOI 10.1037/hea0000496
   Papazoglou I, 2012, MOL CELL ENDOCRINOL, V350, P136, DOI 10.1016/j.mce.2011.12.007
   Perfalk E, 2017, PSYCHONEUROENDOCRINO, V81, P22, DOI 10.1016/j.psyneuen.2017.03.018
   Perry BI, 2020, PSYCHOL MED, V50, P556, DOI 10.1017/S0033291719000308
   Ribas V, 2010, AM J PHYSIOL-ENDOC M, V298, pE304, DOI 10.1152/ajpendo.00504.2009
   Rosenfeld L, 2002, CLIN CHEM, V48, P2270
   Schachter M, 2003, HUM REPROD, V18, P721, DOI 10.1093/humrep/deg190
   Schopohl J, 2009, DEUT MED WOCHENSCHR, V134, P600, DOI 10.1055/s-0029-1208094
   Senthilkumaran M, 2016, NEUROCHEM RES, V41, P1612, DOI 10.1007/s11064-016-1875-3
   Siemienowicz KJ, 2021, MOL CELL ENDOCRINOL, V525, DOI 10.1016/j.mce.2021.111196
   Singh MK, 2019, HORM BEHAV, V108, P73, DOI 10.1016/j.yhbeh.2018.03.009
   Sirmans SM, 2014, CLIN EPIDEMIOL, V6, P1, DOI 10.2147/CLEP.S37559
   Sivasinprasasn S, 2016, MENOPAUSE, V23, P894, DOI 10.1097/GME.0000000000000640
   Stanikova D, 2019, TRANSL PSYCHIAT, V9, DOI 10.1038/s41398-019-0487-5
   Sun KL, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00721
   Teede H, 2010, BMC MED, V8, DOI 10.1186/1741-7015-8-41
   Tye KM, 2013, NATURE, V493, P537, DOI 10.1038/nature11740
   Zhang LL, 2020, BEHAV BRAIN RES, V388, DOI 10.1016/j.bbr.2020.112648
   Zhang XM, 2017, MILITARY MED RES, V4, P1, DOI 10.1186/s40779-017-0131-8
   Zhang YX, 2018, J CLIN NEUROSCI, V47, P1, DOI 10.1016/j.jocn.2017.09.022
   Zhu XQ, 2021, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.587670
NR 69
TC 21
Z9 21
U1 6
U2 85
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JUL 22
PY 2021
VL 12
AR 683474
DI 10.3389/fpsyt.2021.683474
PG 13
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA UE6GF
UT WOS:000687983500001
PM 34366917
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hajat, C
   Siegal, Y
   Adler-Waxman, A
AF Hajat, Cother
   Siegal, Yakir
   Adler-Waxman, Amalia
TI Clustering and Healthcare Costs With Multiple Chronic Conditions in a US
   Study
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE cardiovascular disease; chronic disease; multimorbidity; cancer; mental
   health; healthcare costs; disease clustering
ID CARDIOVASCULAR-DISEASE; MULTIMORBIDITY; IMPACT; HOSPITALIZATION;
   EXPENDITURES; INEQUALITIES; COMORBIDITY; INTEGRATION; PREVALENCE; RISK
AB Objective: To investigate healthcare costs and contributors to costs for multiple chronic conditions (MCCs), common clusters of conditions and their impact on cost and utilization.
   Methods: This was a cross-sectional analysis of US financial claims data representative of the US population, including Medicare, Medicaid, and Commercial insurance claims in 2015. Outcome measures included healthcare costs and contributors; ranking of clusters of conditions according to frequency, strength of association and unsupervised (k-means) analysis; the impact of clustering on costs and contributors to costs.
   Results: Of 1,878,951 patients, 931,045(49.6%) had MCCs, 56.5% weighted to the US population. Mean age was 53.0 years (SD16.7); 393,121(42.20%) were male. Mean annual healthcare spending was $12,601, ranging from $4,385 (2 conditions) to $33,874 (11 conditions), with spending increasing by 22-fold for inpatient services, 6-fold for outpatient services, 4.5-fold for generic drugs, and 4.2-fold for branded drugs. Cluster ranking using the 3 methodologies yielded similar results: highest ranked clusters included metabolic syndrome (12.2% of US insured patients), age related diseases (7.7%), renal failure (5.6%), respiratory disorders (4.5%), cardiovascular disease(CVD) (4.3%), cancers (4.1-4.3%), mental health-related clusters (1.0-1.5%), and HIV/AIDS (0.2%). Highest spending was in HIV/AIDS clusters ($48,293), mental health-related clusters ($38,952-$40,637), renal disease ($38,551), and CVD ($37,155); with 89.9% of spending on outpatient and inpatient care combined, and 10.1% on medication.
   Conclusion and Relevance: Over 57% of insured patients in the US may have MCCs. MCC Clustering is frequent and is associated with healthcare utilization. The findings favor health system redesign toward a multiple condition approach for clusters of chronic conditions, alongside other cost-containment measures for MCCs.
C1 [Hajat, Cother] United Arab Emirates UAE Univ, Publ Hlth Inst, Al Ain, U Arab Emirates.
   [Siegal, Yakir] Deloitte Consulting LLP, New York, NY USA.
   [Adler-Waxman, Amalia] Teva Pharmaceut Ind Ltd, Petah Tiqwa, Israel.
C3 Deloitte Touche Tohmatsu Limited; Teva Pharmaceutical Industries
RP Hajat, C (corresponding author), United Arab Emirates UAE Univ, Publ Hlth Inst, Al Ain, U Arab Emirates.
EM Chajat@doctors.org.uk
OI Hajat, Cother/0000-0002-1763-3010
CR Academy of Medical Science, 2018, MULTIMORBIDITY PRIOR
   Afshar S, 2015, BMC PUBLIC HEALTH, V15, DOI 10.1186/s12889-015-2008-7
   Anderson G., 2010, Chronic Care
   [Anonymous], 2016, HLTH INSURANCE COVER
   Beasley JW, 2004, ANN FAM MED, V2, P405, DOI 10.1370/afm.94
   Fairall LR, 2008, ARCH INTERN MED, V168, P86, DOI 10.1001/archinternmed.2007.10
   Fairall LR, 2016, PLOS MED, V13, DOI 10.1371/journal.pmed.1002178
   Fairall LR, 2005, BMJ-BRIT MED J, V331, P750, DOI 10.1136/bmj.331.7519.750
   Garin N, 2016, J GERONTOL A-BIOL, V71, P205, DOI 10.1093/gerona/glv128
   Global Burden of Disease data, I HLTH METRICS EVALU
   Green A, 2016, LANCET, V388, P1869, DOI 10.1016/S0140-6736(16)31846-3
   Hajat C., 2020, MEDRXIV PREPRINT, DOI [10.1101/2020.08.24.20179184, DOI 10.1101/2020.08.24.20179184]
   Hajat C., 2017, Multiple chronic conditions: The global state
   Hajat Cother, 2018, Prev Med Rep, V12, P284, DOI 10.1016/j.pmedr.2018.10.008
   Hajat C, 2018, BMJ GLOB HEALTH, V3, DOI 10.1136/bmjgh-2018-000874
   Hajat C, 2018, AM J HEALTH PROMOT, V32, P1122, DOI 10.1177/0890117117712355
   Islami F, 2018, CA-CANCER J CLIN, V68, P31, DOI 10.3322/caac.21440
   Jeon CY, 2008, PLOS MED, V5, P1091, DOI 10.1371/journal.pmed.0050152
   Landi F, 2004, J CLIN EPIDEMIOL, V57, P832, DOI 10.1016/j.jclinepi.2004.01.013
   Librero J, 1999, J CLIN EPIDEMIOL, V52, P171, DOI 10.1016/S0895-4356(98)00160-7
   MacQueen J., 1967, P S MATH STAT PROB, P281
   Marengoni A, 2011, AGEING RES REV, V10, P430, DOI 10.1016/j.arr.2011.03.003
   McPhail SM, 2016, RISK MANAG HEALTHC P, V9, P143, DOI 10.2147/RMHP.S97248
   Mueller C, 1997, AM J PUBLIC HEALTH, V87, P1626, DOI 10.2105/AJPH.87.10.1626
   Murphy A, 2018, LANCET GLOB HEALTH, V6, pE292, DOI 10.1016/S2214-109X(18)30031-7
   Mwangemi F., 2010, ORAL PRESENTATION HI
   Rapoport John, 2004, Chronic Dis Can, V25, P13
   Rodgers A, 2003, BMJ-BRIT MED J, V326, P1407, DOI 10.1136/bmj.326.7404.1407
   Salisbury C, 2011, BRIT J GEN PRACT, V61, DOI 10.3399/bjgp11X548929
   Sambamoorthi U, 2003, GERONTOLOGIST, V43, P345, DOI 10.1093/geront/43.3.345
   Schneider KM, 2009, HEALTH QUAL LIFE OUT, V7, DOI 10.1186/1477-7525-7-82
   Schuch FB, 2018, AM J PSYCHIAT, V175, P631, DOI 10.1176/appi.ajp.2018.17111194
   Shelton P, 2000, AM J MANAG CARE, V6, P925
   Singh K, 2019, J PUBLIC HEALTH-UK, V41, P80, DOI 10.1093/pubmed/fdy017
   Sum G, 2018, BMJ GLOB HEALTH, V3, DOI 10.1136/bmjgh-2017-000505
   Uebel KE, 2011, IMPLEMENT SCI, V6, DOI 10.1186/1748-5908-6-86
   Violan C, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0102149
   Ward BW, 2014, PREV CHRONIC DIS, V11, DOI 10.5888/pcd11.130389
   Wolff JL, 2002, ARCH INTERN MED, V162, P2269, DOI 10.1001/archinte.162.20.2269
NR 39
TC 22
Z9 22
U1 1
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD JAN 21
PY 2021
VL 8
AR 607528
DI 10.3389/fpubh.2020.607528
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA QB8JW
UT WOS:000614384600001
PM 33553094
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU He, XW
   Qi, ZD
   Hou, H
   Gao, J
   Zhang, XX
AF He, Xiwei
   Qi, Zhaodong
   Hou, Hui
   Gao, Jie
   Zhang, Xu-Xiang
TI Effects of chronic cadmium exposure at food limitation-relevant levels
   on energy metabolism in mice
SO JOURNAL OF HAZARDOUS MATERIALS
LA English
DT Article
DE Cadmium; Cardiometabolic risk; Chronic low-dose exposure; Energy
   metabolism; Mice gut microbes
ID FATTY LIVER-DISEASE; GUT MICROBIOTA; MECHANISMS; EXPRESSION; STRESS;
   HEART
AB Cadmium (Cd) exposure has been implicated in the perturbation of energy metabolism and the development of cardiometabolic disease, but disease predisposition from chronic low-dose Cd exposure remains unclear. This study employed a mouse model to investigate the toxic effects of chronic Cd exposure at food limitation-relevant levels on energy metabolism and the associated liver and gut microbiome functions. Results showed that the Cd exposure induced the perturbation of energy metabolism in mice, evidenced by the alteration of various metabolites associated with the phosphorogen (adenosine triphosphate-creatine phosphate) system, tricarboxylic acid cycle, and lipid metabolism, as well as the increase of the cardiometabolic risk factor, triglyceride. Moreover, both liver and gut microbiome underwent marked structural/histological and functional alterations, prone to the onset of cardiometabolic disease following the Cd exposure. Certain hepatic transcription factors and gut microbes, specifically PPARa, SREBP1c, HNF4A and the Clostridiales_vadinBB60_group, were identified to be highly correlated with altered urinary metabolites, revealing potential toxicological interactions between the liver and gut microbiome, and energy metabolism. Our findings provide new insights into the progression of metabolic diseases induced by Cd exposure. We also propose a stricter Cd limitation in future food safety standards.
C1 [He, Xiwei; Qi, Zhaodong; Hou, Hui; Gao, Jie; Zhang, Xu-Xiang] Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China.
C3 Nanjing University
RP Zhang, XX (corresponding author), 163 Xianlin Rd, Nanjing 210023, Peoples R China.
EM zhangxx@nju.edu.cn
RI Hou, Huiqiao/KBB-4263-2024
OI Tekile, Ararso Beshea/0009-0005-4990-7118
FU National Key Research & Development Program of China [2018YFF0214105];
   Key R&D Program of Jiangsu Province, China [BE2018632]; Fundamental
   Research Funds for the Central Universities, China [14380116]
FX This study was financially supported by the National Key Research &
   Development Program of China (2018YFF0214105), the Key R&D Program of
   Jiangsu Province, China (BE2018632) and the Fundamental Research Funds
   for the Central Universities, China (14380116).
CR Abu-Shanab A, 2010, NAT REV GASTRO HEPAT, V7, P691, DOI 10.1038/nrgastro.2010.172
   [Anonymous], 2011, J CHONGQING U ARTS S
   [Anonymous], [No title captured]
   Baciu C, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0189223
   Bajaj JS, 2015, SCI REP-UK, V5, DOI [10.1038/srep18559, 10.1038/srep20447]
   Benet M, 2014, ARCH TOXICOL, V88, P967, DOI 10.1007/s00204-014-1197-7
   Boursier J, 2016, HEPATOLOGY, V63, P764, DOI 10.1002/hep.28356
   Breton J, 2013, TOXICOL LETT, V222, P132, DOI 10.1016/j.toxlet.2013.07.021
   Cao ZW, 2017, J PINEAL RES, V62, DOI 10.1111/jpi.12389
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Chen Long, 2003, Sheng Li Xue Bao, V55, P535
   Costa RH, 2003, HEPATOLOGY, V38, P1331, DOI 10.1016/j.hep.2003.09.034
   Del Chierico F, 2017, HEPATOLOGY, V65, P451, DOI 10.1002/hep.28572
   Dumas ME, 2006, P NATL ACAD SCI USA, V103, P12511, DOI 10.1073/pnas.0601056103
   Fan JG, 2005, J HEPATOL, V43, P508, DOI 10.1016/j.jhep.2005.02.042
   Feingold K, 2004, AM J PHYSIOL-ENDOC M, V286, pE201, DOI 10.1152/ajpendo.00205.2003
   Go YM, 2015, TOXICOL SCI, V147, P524, DOI 10.1093/toxsci/kfv149
   Go YM, 2014, TOXICOL SCI, V139, P59, DOI 10.1093/toxsci/kfu018
   Grundy SM, 2012, J AM COLL CARDIOL, V59, P635, DOI 10.1016/j.jacc.2011.08.080
   Guo JH, 2018, GENES-BASEL, V9, DOI 10.3390/genes9040192
   Hammer Oyvind, 2001, Palaeontologia Electronica, V4, pUnpaginated
   Hosokawa T, 2006, PLOS BIOL, V4, P1841, DOI 10.1371/journal.pbio.0040337
   Jordan J, 2012, J PROTEOME RES, V11, P1133, DOI 10.1021/pr200840b
   Kanehisa M, 2012, NUCLEIC ACIDS RES, V40, pD109, DOI 10.1093/nar/gkr988
   Kirk EP, 2009, J CLIN HYPERTENS, V11, P761, DOI 10.1111/j.1559-4572.2009.00054.x
   Larregle EV, 2008, FOOD CHEM TOXICOL, V46, P1786, DOI 10.1016/j.fct.2008.01.018
   LIN JK, 1992, FOOD CHEM TOXICOL, V30, P695, DOI 10.1016/0278-6915(92)90165-H
   Liu J, 2009, TOXICOL APPL PHARM, V238, P209, DOI 10.1016/j.taap.2009.01.029
   Liu P, 2018, ENVIRON SCI POLLUT R, V25, P18762, DOI 10.1007/s11356-018-1783-y
   Liu QQ, 2012, P NATL ACAD SCI USA, V109, P14568, DOI 10.1073/pnas.1211611109
   Liu YH, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0085323
   Mao ZL, 2019, NANOSCALE RES LETT, V14, DOI 10.1186/s11671-018-2834-5
   Marques TM, 2015, BRIT J NUTR, V113, P728, DOI 10.1017/S0007114514004206
   Miltonprabu S, 2016, TOXICOL REP, V3, P63, DOI 10.1016/j.toxrep.2015.11.010
   Nicholson JK, 2012, SCIENCE, V336, P1262, DOI 10.1126/science.1223813
   Rietschel ET, 1998, MICROB DRUG RESIST, V4, P37, DOI 10.1089/mdr.1998.4.37
   Rikans LE, 2000, J BIOCHEM MOL TOXIC, V14, P110, DOI 10.1002/(SICI)1099-0461(2000)14:2<110::AID-JBT7>3.0.CO;2-J
   Sanchez-Alcoholado L, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01936
   Satarug S, 2010, ENVIRON HEALTH PERSP, V118, P182, DOI 10.1289/ehp.0901234
   Scally C, 2017, CIRCULATION, V136
   Schnabl B, 2014, GASTROENTEROLOGY, V146, P1513, DOI 10.1053/j.gastro.2014.01.020
   Sheng LL, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-01576-9
   Souto G, 2011, METAB SYNDR RELAT D, V9, P247, DOI 10.1089/met.2010.0108
   Spencer MD, 2011, GASTROENTEROLOGY, V140, P976, DOI 10.1053/j.gastro.2010.11.049
   Tsai TY, 2017, SCI REP-UK, V7, DOI 10.1038/srep41452
   Wan YJY, 2000, MOL CELL BIOL, V20, P4436, DOI 10.1128/MCB.20.12.4436-4444.2000
   Wang ZN, 2011, NATURE, V472, P57, DOI 10.1038/nature09922
   Watanabe K, 2018, OBES SURG, V28, P1532, DOI 10.1007/s11695-017-3052-4
   Xian-Cheng J, 2005, J BIOL CHEM, V280, P18336, DOI 10.1074/jbc.M500007200
   Yazihan N, 2011, HUM EXP TOXICOL, V30, P391, DOI 10.1177/0960327110372402
   Yin M, 2001, HEPATOLOGY, V34, P935, DOI 10.1053/jhep.2001.28888
   Yu YR, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.02233
   Zeng B, 2019, RES MICROBIOL, V170, P43, DOI 10.1016/j.resmic.2018.09.002
   Zhang SB, 2015, CHEM RES TOXICOL, V28, P2000, DOI 10.1021/acs.chemrestox.5b00237
   Zhang Y, 2013, ENVIRON SCI TECHNOL, V47, P2918, DOI 10.1021/es3048976
   Zou LJ, 2019, J SCI FOOD AGR, V99, P1643, DOI 10.1002/jsfa.9348
NR 56
TC 30
Z9 31
U1 4
U2 80
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0304-3894
EI 1873-3336
J9 J HAZARD MATER
JI J. Hazard. Mater.
PD APR 15
PY 2020
VL 388
AR 121791
DI 10.1016/j.jhazmat.2019.121791
PG 9
WC Engineering, Environmental; Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Environmental Sciences & Ecology
GA LB2JV
UT WOS:000524462500064
PM 31818666
DA 2025-06-11
ER

PT J
AU Alim, NE
   Demir, G
   Dundar, S
   Fidan, ÖPT
   Coker, F
AF Alim, Nural Erzurum
   Demir, Gulbin
   Dundar, Selin
   Fidan, Oyku Peren Turk
   Coker, Fatma
TI Evaluation of Nutrient Intake in Bipolar Disorder I Patients According
   to Body Mass Index Level: A Pilot Study
SO PROGRESS IN NUTRITION
LA English
DT Article
DE Bipolar disorder; diet; obesity; body mass index; psychiatry
ID LIFE-STYLE FACTORS; GENDER-DIFFERENCES; METABOLIC SYNDROME; OBESITY;
   ASSOCIATION; PREVALENCE; HEALTH; ADULTS
AB Background: Bipolar disorders (BD) are severe psychiatric disorders defined by variable mania or hypomania attacks, depression, or mixtures of manic and depressive features. Bipolar disorder I (BDI) is associated with obesity and nutrition. Objectives: To determine the nutritional status and evaluate the anthropometric measurements of BDI patients at Samsun Mental Health and Diseases Hospital. Subjects and methods: This casecontrolled study was carried out among 50 BDI patients and 38 normal healthy volunteer individuals. Food frequency questionnaire was applied to the participants and anthropometric measurements were determined. Biochemical tests were retrospectively performed. Results: The mean energy, protein, and Omega 6 intake of the BDI group was significantly higher than the control group (p < 0.05). The mean waist circumference, waist/height ratio, and the frequency of obesity in the BDI group were statistically higher than the control group (p < 0.05). Hemoglobin, triglyceride, CRP and T3 were significantly higher in the BDI group compared to the control group (p < 0.05). Protein, lipid, carbohydrate, and fiber intake of the individuals differed according to their health status (p = 0.016, p < 0.001, p < 0.001, p = 0.007, respectively). At the same time, the interaction between health status and BMI levels was also significant (p = 0.019). Conclusions: The data obtained may help assess the nutrition of BDI patients. Nutritional assessment should be a part of the plan of care in BDI patients.
C1 [Alim, Nural Erzurum; Fidan, Oyku Peren Turk] Ankara Yildirim Beyazit Univ, Dept Nutr & Dietet, Fac Hlth Sci, TR-06760 Ankara, Turkey.
   [Demir, Gulbin; Coker, Fatma] Minist Hlth, Samsun Prov Hlth Directorate, Mental Hlth & Dis Hosp, Samsun, Turkey.
   [Dundar, Selin] Minist Hlth, Gen Directorate Publ Hlth, Canc Dept, TR-06100 Ankara, Turkey.
C3 Ankara Yildirim Beyazit University; Ministry of Health - Turkey;
   Ministry of Health - Turkey
RP Alim, NE (corresponding author), Ankara Yildirim Beyazit Univ, Dept Nutr & Dietet, Fac Hlth Sci, TR-06760 Ankara, Turkey.
EM nalim@ybu.edu.tr
RI ERZURUM ALIM, Nural/E-8236-2019
OI TURK, OYKU PEREN/0000-0003-1215-2581
CR [Anonymous], 2013, DIAGNOSTIC STAT MANU
   [Anonymous], 2014, PRIMARY CARE COMPANI
   Arias F, 2017, ADICCIONES, V29, P186, DOI 10.20882/adicciones.782
   Bauer M, 2014, BIPOLAR DISORD, V16, P58, DOI 10.1111/bdi.12150
   Belmaker RH, 2004, NEW ENGL J MED, V351, P476, DOI 10.1056/NEJMra035354
   Bernstein EE, 2015, AUST NZ J PSYCHIAT, V49, P566, DOI 10.1177/0004867414565479
   Besler HT, 2015, TURKIYEYE OZGU BESIN, V1
   Beyer JL, 2016, PSYCHIAT CLIN N AM, V39, P75, DOI 10.1016/j.psc.2015.10.003
   Bly MJ, 2014, BIPOLAR DISORD, V16, P277, DOI 10.1111/bdi.12160
   Bobo WV, 2017, DIAGNOSIS MANAGEMENT
   Calkin C, 2009, BIPOLAR DISORD, V11, P650, DOI 10.1111/j.1399-5618.2009.00730.x
   Chang HH, 2009, J AFFECT DISORDERS, V117, P124, DOI 10.1016/j.jad.2008.12.018
   Dagani J., 2019, Age of Onset of Mental Disorders: Etiopathogenetic and Treatment Implications, P75
   de Almeida KM, 2012, CNS NEUROSCI THER, V18, P160, DOI 10.1111/j.1755-5949.2011.00240.x
   Diflorio A, 2010, INT REV PSYCHIATR, V22, P437, DOI 10.3109/09540261.2010.514601
   Elmslie JL, 2001, J CLIN PSYCHIAT, V62, P486, DOI 10.4088/JCP.v62n0614
   Hays J C, 1998, Depress Anxiety, V7, P76, DOI 10.1002/(SICI)1520-6394(1998)7:2<76::AID-DA5>3.3.CO;2-C
   Jacka FN, 2011, PSYCHOSOM MED, V73, P483, DOI 10.1097/PSY.0b013e318222831a
   Kim B, 2008, J AFFECT DISORDERS, V105, P45, DOI 10.1016/j.jad.2007.04.006
   Krishna VN, 2013, ASIAN J PSYCHIATR, V6, P42, DOI 10.1016/j.ajp.2012.08.003
   Martin K, 2016, J AFFECT DISORDERS, V195, P88, DOI 10.1016/j.jad.2016.02.030
   McElroy SL, 2012, CURR PSYCHIAT REP, V14, P650, DOI 10.1007/s11920-012-0313-8
   Merikangas KR, 2011, ARCH GEN PSYCHIAT, V68, P241, DOI 10.1001/archgenpsychiatry.2011.12
   Rakicioglu N, 2009, YEMEK VE BESIN FOTOG
   Salem A, 2018, CUREUS J MED SCIENCE, V10, DOI 10.7759/cureus.3242
   Sicras A, 2008, BIPOLAR DISORD, V10, P607, DOI 10.1111/j.1399-5618.2008.00599.x
   Sigitova E, 2017, PSYCHIAT CLIN NEUROS, V71, P77, DOI 10.1111/pcn.12476
   Simmons-Alling Susan, 2008, J Am Psychiatr Nurses Assoc, V13, P345, DOI 10.1177/10783903080130060401
   Simon GE, 2006, ARCH GEN PSYCHIAT, V63, P824, DOI 10.1001/archpsyc.63.7.824
   Stanley S, 2014, INT J BEHAV MED, V21, P275, DOI 10.1007/s12529-013-9298-x
   Stubbs B, 2016, AUST NZ J PSYCHIAT, V50, P631, DOI 10.1177/0004867415623857
   Tryon MS, 2015, J CLIN ENDOCR METAB, V100, P2239, DOI 10.1210/jc.2014-4353
   Zhang L, 2017, J AFFECT DISORDERS, V207, P413, DOI 10.1016/j.jad.2016.08.062
   [No title captured]
NR 34
TC 2
Z9 2
U1 0
U2 3
PU MATTIOLI 1885
PI FIDENZA
PA VIA DELLA LODESANA 649-SX, FIDENZA, 43046 PR, ITALY
SN 1129-8723
J9 PROG NUTR
JI Prog. Nutr.
PD SEP
PY 2020
VL 22
IS 3
AR e2020039
DI 10.23751/pn.v22i3.9542
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OJ3QJ
UT WOS:000583879700040
DA 2025-06-11
ER

PT J
AU Satake, O
   Kajinami, K
   Ishikawa, Y
   Ueda, T
   Tsugawa, H
   Kanemitsu, S
   Okubo, S
   Takekoshi, N
AF Satake, O
   Kajinami, K
   Ishikawa, Y
   Ueda, T
   Tsugawa, H
   Kanemitsu, S
   Okubo, S
   Takekoshi, N
TI Myocardial glucose metabolism assessed by positron emission tomography
   and the histopathologic findings of microvessels in syndrome X
SO CIRCULATION JOURNAL
LA English
DT Article
DE histopathology; microvessels; positron emission tomography; syndrome X
ID NORMAL CORONARY-ARTERIES; ANGINA-PECTORIS; MICROVASCULAR ANGINA; CHEST
   PAIN; VASODILATOR RESERVE; HEART-DISEASE; FLOW RESERVE; ARTERIOGRAMS;
   PERFUSION; ISCHEMIA
AB Background Syndrome X has been recognized as a disease that is primarily reflected in the cardiac microvasculature. Myocardial metabolism in this condition has been studied, but not in relation to small vessel pathology.
   Methods and Results In order to examine the relationship between myocardial metabolism and small vessel pathology, 24 consecutive patients with syndrome X (7 men, 17 women; mean age 58 years) were evaluated by the thallium exercise stress test, positron emission tomography using F-18 fluoro-deoxy glucose (FDG), and an endomyocardial biopsy. All patients showed either diffuse or focal increase in the myocardial uptake of FDG, but only 17 patients (71%) showed hypoperfused areas with partial or complete redistribution in the thalliurn study. Quantification of myocardial FDG uptake revealed that the value in syndrome X patients was 10-fold higher than in controls (p<0.0001). Histopathological examination revealed that in syndrome X there is an extensive increase in smooth muscle cells and thickening of the vascular wall, even in capillary vessels, and the small vessel lumen was markedly narrowed. There was a significant inverse correlation between FDG myocardial uptake and the microvessel luminal area.
   Conclusions In syndrome X patients, myocardial FDG uptake is increased extensively, which is strongly associated with narrowed myocardial microvasculature.
C1 Kanazawa Med Univ, Dept Cardiol, Uchinada, Ishikawa 9200293, Japan.
   Kanazawa Med Univ, Dept Pathol 2, Uchinada, Ishikawa 9200293, Japan.
   Kanazawa Med Univ, Dept Anat, Uchinada, Ishikawa 9200293, Japan.
C3 Kanazawa Medical University; Kanazawa Medical University; Kanazawa
   Medical University
RP Kanazawa Med Univ, Dept Cardiol, 1-1 Daigaku, Uchinada, Ishikawa 9200293, Japan.
EM o-satake@kanazawa-med.ac.jp
RI Kajinami, Kouji/AAA-6769-2022
CR Arrighi JA, 2001, J NUCL CARDIOL, V8, P417, DOI 10.1067/mnc.2001.115646
   BERGER BC, 1983, AM J CARDIOL, V52, P365, DOI 10.1016/0002-9149(83)90140-6
   Botker HE, 1997, AM J CARDIOL, V79, P1615, DOI 10.1016/S0002-9149(97)00209-9
   Bottcher M, 1999, CIRCULATION, V99, P1795
   BRUNKEN R, 1987, J AM COLL CARDIOL, V10, P557, DOI 10.1016/S0735-1097(87)80198-5
   CAMICI PG, 1992, CIRCULATION, V86, P179, DOI 10.1161/01.CIR.86.1.179
   CAMICI PG, 1991, J AM COLL CARDIOL, V17, P1461, DOI 10.1016/0735-1097(91)90632-J
   CANNON RO, 1992, CIRCULATION, V85, P883, DOI 10.1161/01.CIR.85.3.883
   CANNON RO, 1988, AM J CARDIOL, V61, P1338, DOI 10.1016/0002-9149(88)91180-0
   Egashira K, 2002, CIRC J, V66, P529, DOI 10.1253/circj.66.529
   EGASHIRA K, 1993, NEW ENGL J MED, V328, P1659, DOI 10.1056/NEJM199306103282302
   EPSTEIN SE, 1986, J AM COLL CARDIOL, V8, P459, DOI 10.1016/S0735-1097(86)80067-5
   GREENBERG MA, 1987, J AM COLL CARDIOL, V9, P743, DOI 10.1016/S0735-1097(87)80227-9
   HOLDRIGHT DR, 1993, BRIT HEART J, V70, P513
   Jain D, 2000, J NUCL CARDIOL, V7, P286, DOI 10.1016/S1071-3581(00)70020-1
   KASKI JC, 1995, AM J CARDIOL, V76, pD35
   KAUL S, 1986, AM J CARDIOL, V57, P509, DOI 10.1016/0002-9149(86)90825-8
   Kemp H G, 1967, Trans Assoc Am Physicians, V80, P59
   KEMP HG, 1973, AM J CARDIOL, V32, P375, DOI 10.1016/S0002-9149(73)80150-X
   LIKOFF W, 1967, NEW ENGL J MED, V276, P1063, DOI 10.1056/NEJM196705112761904
   MARSHALL RC, 1983, CIRCULATION, V67, P766, DOI 10.1161/01.CIR.67.4.766
   MASERI A, 1991, J AM COLL CARDIOL, V17, P499, DOI 10.1016/S0735-1097(10)80122-6
   MELLER J, 1979, AM J CARDIOL, V43, P717, DOI 10.1016/0002-9149(79)90069-9
   MOSSERI M, 1991, CIRCULATION, V84, P203, DOI 10.1161/01.CIR.84.1.203
   MOSSERI M, 1986, CIRCULATION, V74, P964, DOI 10.1161/01.CIR.74.5.964
   OPHERK D, 1981, CIRCULATION, V63, P817, DOI 10.1161/01.CIR.63.4.817
   Panting JR, 2002, NEW ENGL J MED, V346, P1948, DOI 10.1056/NEJMoa012369
   RICHARDSON PJ, 1974, LANCET, V21, P677
   ROSEN SD, 1994, CIRCULATION, V90, P50, DOI 10.1161/01.CIR.90.1.50
   SAX FL, 1987, NEW ENGL J MED, V317, P1366, DOI 10.1056/NEJM198711263172202
   Suzuki H, 1995, Am J Cardiovasc Pathol, V5, P19
   SUZUKI H, 1994, INT J CARDIOL, V43, P139, DOI 10.1016/0167-5273(94)90003-5
   Suzuki H, 2002, CIRC J, V66, P691, DOI 10.1253/circj.66.691
   Yokoyama I, 2000, J NUCL MED, V41, P978
NR 34
TC 17
Z9 18
U1 0
U2 1
PU JAPANESE CIRCULATION SOC
PI TOYKO
PA 6th Floor, Uchikanda Central Building, 1-18-13 Uchikanda, Chiyoda-ku,
   TOYKO, 101-0047, JAPAN
SN 1346-9843
EI 1347-4820
J9 CIRC J
JI Circ. J.
PD MAR
PY 2004
VL 68
IS 3
BP 220
EP 226
DI 10.1253/circj.68.220
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 779UJ
UT WOS:000189319500008
PM 14993776
OA Bronze
DA 2025-06-11
ER

PT J
AU Cranwell, K
   Polacsek, M
   McCann, TV
AF Cranwell, Kate
   Polacsek, Meg
   McCann, Terence V.
TI Improving mental health service users' with medical co-morbidity
   transition between tertiary medical hospital and primary care services:
   a qualitative study
SO BMC HEALTH SERVICES RESEARCH
LA English
DT Article
DE Service users' and caregivers' experience; Experience-based co-design;
   Mental Health Hospital Admission Reduction Program; Medical
   co-morbidity; Transition
ID METABOLIC SYNDROME; YOUNG-PEOPLE; ILLNESS; SCHIZOPHRENIA; STIGMA;
   DISCRIMINATION; SATISFACTION; EXPERIENCES; RELEVANCE
AB Background: Mental health service users have high rates of medical co-morbidity but frequently experience problems accessing and transitioning between tertiary medical and primary care services. The aim of this study was to identify ways to improve service users' with medical co-morbidity care and experience during their transition between tertiary medical hospitals and primary care services.
   Method: Experience-based co-design (EBCD) qualitative study incorporating a focus group discussion. The study took place in a large tertiary medical service, incorporating three medical hospitals, and primary care services, in Melbourne, Australia. A purposive sample of service users and their caregivers and tertiary medical and primary care clinicians participated in the focus group discussion, in August 2014. A semi-structured interview guide was used to inform data collection. A thematic analysis of the data was undertaken.
   Results: Thirteen participants took part in the focus group interview, comprising 5 service users, 2 caregivers and 6 clinicians. Five themes were abstracted from the data, illustrating participants' perspectives about factors that facilitated (clinicians' expertise, engagement and accessibility enhancing transition) and presented as barriers (improving access pathways; enhancing communication and continuity of care; improving clinicians' attitudes; and increasing caregiver participation) to service users' progress through tertiary medical and primary care services. A sixth theme, enhancing service users' transition, incorporated three strategies to enhance their transition through tertiary medical and primary care services.
   Conclusion: EBCD is a useful approach to collaboratively develop strategies to improve service users' with medical co-morbidity and their caregivers' transition between tertiary medical and primary care services. A whole-of-service approach, incorporating policy development and implementation, change of practice philosophy, professional development education and support for clinicians, and acceptance of the need for caregiver participation, is required to improve service users' transition.
C1 [Cranwell, Kate; Polacsek, Meg] Western Hlth, Community Serv, Melbourne, Vic, Australia.
   [Polacsek, Meg; McCann, Terence V.] Victoria Univ, Discipline Nursing, Coll Hlth & Biomed, Ctr Chron Dis, POB 14428, Melbourne, Vic 8001, Australia.
C3 Western Health; Victoria University
RP McCann, TV (corresponding author), Victoria Univ, Discipline Nursing, Coll Hlth & Biomed, Ctr Chron Dis, POB 14428, Melbourne, Vic 8001, Australia.
EM terence.mccann@vu.edu.au
OI Mccann, Terence/0000-0003-1109-0438; Polacsek, Meg/0000-0002-2945-3594
FU Australian Primary Health Care Research Institute, Canberra
FX The authors declare receipt of the following financial support for the
   study: The study was funded by a grant from the Australian Primary
   Health Care Research Institute, Canberra.
CR Album D, 2008, SOC SCI MED, V66, P182, DOI 10.1016/j.socscimed.2007.07.003
   [Anonymous], MED J AUST
   [Anonymous], NAT PARTN AGR SUPP N
   Bowen SJ, 2013, ARCH PHYS MED REHAB, V94, pS3, DOI 10.1016/j.apmr.2012.04.037
   Braun V., 2006, Qualitative Research in Psychology, V3, P77, DOI [10.1191/1478088706qp063oa, DOI 10.1191/1478088706QP063OA]
   Chang CK, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019590
   Clarke DE, 2007, INT J MENT HEALTH NU, V16, P126, DOI 10.1111/j.1447-0349.2007.00455.x
   Corrigan PW, 2015, PSYCHIAT SERV, V66, P1347, DOI 10.1176/appi.ps.201500107
   Cranwell K, 2016, INT J MENT HEALTH NU, V25, P127, DOI 10.1111/inm.12174
   Dickerson FB, 2002, SCHIZOPHRENIA BULL, V28, P143, DOI 10.1093/oxfordjournals.schbul.a006917
   Donetto S., 2014, Using Experience-based Co-design (EBCD) to improve the quality of healthcare: mapping where we are now and establishing future directions
   Ewertzon M, 2010, J PSYCHIATR MENT HLT, V17, P422, DOI 10.1111/j.1365-2850.2009.01539.x
   Fagiolini A, 2009, J CLIN PSYCHIAT, V70, P22, DOI 10.4088/JCP.7075su1c.04
   Freeman T, 2006, J ADV NURS, V56, P491, DOI 10.1111/j.1365-2648.2006.04043.x
   Gerson R, 2009, PSYCHIAT SERV, V60, P812, DOI 10.1176/ps.2009.60.6.812
   Green J, 1999, BRIT MED J, V319, P421
   Guba E.G., 2005, SAGE HDB QUALITATIVE, P191
   Holloway I., 2010, Qualitative Research in Nursing and Healthcare, V3rd
   Hutchinson S A, 1993, NLN Publ, P180
   Jones AA, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2015-008876
   Keating F, 2004, HEALTH SOC CARE COMM, V12, P439, DOI 10.1111/j.1365-2524.2004.00506.x
   Kilbourne AM, 2006, INT J PSYCHIAT MED, V36, P383, DOI 10.2190/04XR-3107-4004-4670
   Krueger R.A., 2000, Focus groups, V3rd
   Lally J, 2015, GEN HOSP PSYCHIAT, V37, P577, DOI 10.1016/j.genhosppsych.2015.07.006
   Lincoln Y. S., 1985, NATURALISTIC INQUIRY
   McCann TV, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/1471-244X-14-168
   McCann TV, 2012, J CLIN NURS, V21, P224, DOI 10.1111/j.1365-2702.2011.03836.x
   Mitchell AJ, 2009, BRIT J PSYCHIAT, V194, P491, DOI 10.1192/bjp.bp.107.045732
   Newcomer JW, 2009, J CLIN PSYCHIAT, V70, P30, DOI 10.4088/JCP.7075su1c.05
   Ngamini-Ngui A, 2014, PSYCHIAT SERV, V65, P1389, DOI 10.1176/appi.ps.201300474
   Nyboe L, 2015, SCHIZOPHR RES, V168, P381, DOI 10.1016/j.schres.2015.07.053
   Osborn DPJ, 2008, BMC PSYCHIATRY, V8, DOI 10.1186/1471-244X-8-84
   Parahoo K., 2014, Nursing research: Principles, process and issues
   Razzano LA, 2015, SCHIZOPHR RES, V161, P458, DOI 10.1016/j.schres.2014.11.021
   Robert G, 2015, BMJ-BRIT MED J, V350, DOI 10.1136/bmj.g7714
   Ross CA, 2009, J PSYCHIATR MENT HLT, V16, P558, DOI 10.1111/j.1365-2850.2009.01399.x
   SANDELOWSKI M, 1993, ADV NURS SCI, V16, P1
   Schoepf D, 2014, EUR ARCH PSY CLIN N, V264, P3, DOI 10.1007/s00406-013-0436-x
   Scott KM, 2009, PSYCHOL MED, V39, P33, DOI 10.1017/S0033291708003188
   Short DD, 2009, PSYCHIAT CLIN N AM, V32, P759, DOI 10.1016/j.psc.2009.09.005
   Sin J, 2005, J Psychiatr Ment Health Nurs, V12, P589, DOI 10.1111/j.1365-2850.2005.00883.x
   Thornicroft G, 2007, INT REV PSYCHIATR, V19, P113, DOI 10.1080/09540260701278937
   Tse J, 2011, PSYCHIAT ANN, V41, P473, DOI 10.3928/00485713-20110921-05
NR 43
TC 16
Z9 18
U1 0
U2 20
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6963
J9 BMC HEALTH SERV RES
JI BMC Health Serv. Res.
PD JUL 26
PY 2016
VL 16
AR 302
DI 10.1186/s12913-016-1567-3
PG 9
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA DS2WS
UT WOS:000380645200004
PM 27456864
OA Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Pearsall, R
   Hughes, S
   Geddes, J
   Pelosi, A
AF Pearsall, Robert
   Hughes, Susan
   Geddes, John
   Pelosi, Anthony
TI Understanding the problems developing a healthy living programme in
   patients with serious mental illness: a qualitative study
SO BMC PSYCHIATRY
LA English
DT Article
DE Healthy living; Physical health; Qualitative study; Serious mental
   illness; Healthy living programme
ID PHYSICAL-ACTIVITY; WEIGHT-GAIN; ANTIPSYCHOTIC TREATMENT; METABOLIC
   SYNDROME; SMOKING-CESSATION; SCHIZOPHRENIA; PEOPLE; BARRIERS; RISK;
   MORTALITY
AB Background: People with serious mental illness are at an increased risk of physical ill health. Mortality rates are around twice those of the general population with higher levels of cardiovascular disease, metabolic disease, diabetes, and respiratory illness. Although genetics may have a role in the physical health problems of these patients, lifestyle and environmental factors such as smoking, obesity, poor diet, and low levels of physical activity play a prominent part.
   Methods: A qualitative grounded theory approach was used to understand the problems experienced by these individuals when asked to attend a healthy living programme. Three main areas were explored: the influence of potential barriers, health problems, and general attitudes towards healthy living.
   Results: Thirteen patients were interviewed during the study. Many did not recall receiving an initial invitation letter to the programme. Several believed that there was no necessity to attend as they had already had recent routine health checks by their general practitioner. The patients' current level of mental and physical health was important with symptoms such as depression, anxiety or arthritis affecting interest in the programme. Patients described that they found smoking enjoyable or calming in its effect. Dietary intake was determined by taste or gaining pleasure in eating certain types of food. Several lessons were learnt during this research that may aid future research and practice. Participation seemed to be better if the approach was first made by the patient's own community keyworker. This contact may have provided a greater opportunity to explain the purpose and importance of the programme. Alternative appointments should be considered when certain patients are in better physical and mental health. Healthy living programmes need to be flexible and adaptive to individual patient needs. Assistance from their community worker may help engagement. Simple measures may improve participation and reduce potential barriers.
   Conclusion: These findings highlighted some of the problems encountered by patients when attempting to participate in a healthy living programme. These results may be useful when implementing future healthy living interventions for patients with serious mental disorders.
C1 [Pearsall, Robert] Monklands Hosp, Dept Psychiat, Airdrie, AB, Canada.
   [Hughes, Susan] Community Hlth Clin, Carluke, Scotland.
   [Geddes, John] Univ Oxford, Dept Psychiat, Oxford, England.
   [Pelosi, Anthony] St Johns Hosp, Reg Eating Disorders Unit, Livingston, Scotland.
C3 University of Oxford
RP Pearsall, R (corresponding author), Monklands Hosp, Dept Psychiat, Airdrie, AB, Canada.
EM robert.pearsall@nhs.net
RI Geddes, John/B-8240-2011; Pelosi, Anthony/MTD-9608-2025
OI Geddes, John/0000-0002-5281-5960; Pelosi, Anthony/0000-0002-5501-2661
FU MRC; ESRC; NIHR; Stanley Medical Research Institute
FX RP, SH, and AP declared no competing interests. JG has received research
   funding from MRC, ESRC, NIHR, Stanley Medical Research Institute and has
   received donations of drugs supplies for trials from Sanofi-Aventis and
   GSK. He has acted as an expert witness for Dr Reddys.
CR Allison DB, 1999, AM J PSYCHIAT, V156, P1686
   [Anonymous], 2012, AB ILLN REP SCHIZ CO
   [Anonymous], 2008, SCOTT HLTH SURV
   Brown S, 1999, PSYCHOL MED, V29, P697, DOI 10.1017/S0033291798008186
   Brown S, 1997, BRIT J PSYCHIAT, V171, P502, DOI 10.1192/bjp.171.6.502
   Brunero S, 2009, INT J MENT HEALTH NU, V18, P144, DOI 10.1111/j.1447-0349.2009.00595.x
   Cresswell J.W., 1998, QUAL INQ
   Daumit GL, 2005, J NERV MENT DIS, V193, P641, DOI 10.1097/01.nmd.0000180737.85895.60
   De Hert M, 2011, BRIT J PSYCHIAT, V199, P99, DOI 10.1192/bjp.bp.110.084665
   De Hert M, 2009, WORLD PSYCHIATRY, V8, P15
   Filik R, 2006, ACTA PSYCHIAT SCAND, V113, P298, DOI 10.1111/j.1600-0447.2006.00768.x
   George TP, 2008, BIOL PSYCHIAT, V63, P1092, DOI 10.1016/j.biopsych.2007.11.002
   Goff DC, 2005, SCHIZOPHR RES, V80, P45, DOI 10.1016/j.schres.2005.08.010
   Green AI, 2000, GEN HOSP PSYCHIAT, V22, P224, DOI 10.1016/S0163-8343(00)00081-5
   Johnstone R, 2009, J MENT HEALTH, V18, P523, DOI 10.3109/09638230903111114
   Kerr S, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-221
   Lawn SJ, 2002, SOC SCI MED, V54, P93, DOI 10.1016/S0277-9536(01)00008-9
   Leucht S, 2007, ACTA PSYCHIAT SCAND, V116, P317, DOI 10.1111/j.1600-0447.2007.01095.x
   Mauri M, 2008, PHARMACOPSYCHIATRY, V41, P17, DOI 10.1055/s-2007-992148
   McDevitt J, 2006, J NURS SCHOLARSHIP, V38, P50, DOI 10.1111/j.1547-5069.2006.00077.x
   Miller BJ, 2011, BMJ-BRIT MED J, V343, DOI 10.1136/bmj.d5652
   Muir-Cochrane E, 2006, J PSYCHIATR MENT HLT, V13, P447, DOI 10.1111/j.1365-2850.2006.01002.x
   Mukherjee S, 1996, COMPR PSYCHIAT, V37, P68, DOI 10.1016/S0010-440X(96)90054-1
   Newcomer JW, 2002, ARCH GEN PSYCHIAT, V59, P337, DOI 10.1001/archpsyc.59.4.337
   NVivo, QUAL SOFTW VERS 8 0
   Paton C, 2004, ACTA PSYCHIAT SCAND, V110, P299, DOI 10.1111/j.1600-0447.2004.00372.x
   Pearsall R, 2012, THESIS U OXFORD
   Roberts L, 2007, FAM PRACT, V24, P34, DOI 10.1093/fampra/cml054
   Ryan MCM, 2003, AM J PSYCHIAT, V160, P284, DOI 10.1176/appi.ajp.160.2.284
   Saha S, 2007, ARCH GEN PSYCHIAT, V64, P1123, DOI 10.1001/archpsyc.64.10.1123
   The Scottish Government, 2010, SCOTT HLTH SURV
   The Scottish Office, 1999, HLTH SCOTL WHIT PAP
   Tosh G, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008298.pub2
NR 33
TC 13
Z9 15
U1 0
U2 40
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD FEB 14
PY 2014
VL 14
AR 38
DI 10.1186/1471-244X-14-38
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AC6ZE
UT WOS:000332674700001
PM 24524248
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yuan, XL
   Liu, W
   Ni, WQ
   Sun, YY
   Zhang, HM
   Zhang, Y
   Yin, P
   Xu, J
AF Yuan, Xueli
   Liu, Wei
   Ni, Wenqing
   Sun, Yuanying
   Zhang, Hongmin
   Zhang, Yan
   Yin, Peng
   Xu, Jian
TI Concordance of Non-Alcoholic Fatty Liver Disease and Associated Factors
   among Older Married Couples in China
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE older couples; non-alcoholic fatty liver disease; spousal concordance;
   risk factors; lifestyle
ID SPOUSAL CONCORDANCE; METABOLIC SYNDROME; PHYSICAL HEALTH; MENTAL-HEALTH;
   DEPRESSION; SIMILARITY; MANAGEMENT; RISK
AB Background: Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases which affects mainly middle-aged and older adults, resulting in a considerable disease burden. Evidence of concordance on NAFLD and lifestyle factors within older married couples in China is limited. This study aimed to evaluate spousal concordance regarding lifestyle factors and NAFLD among older Chinese couples. Methods: We conducted a cross-sectional study using data from 58,122 married couples aged 65 years and over recruited from Shenzhen, China during 2018-2020. Logistic regression analyses were used to estimate the reciprocal associations in NAFLD within couples after incremental adjustment for potential confounders. Results: There was a marked concordance regarding NAFLD among older married couples in our study. After adjustment for confounders, the odds of having NAFLD were significantly related to the person's spouse also having NAFLD (1.84 times higher in husbands and 1.79 times higher in wives). The spousal concordance of NAFLD was similar, irrespective of gender. Couples with both a higher educational level and abdominal obesity were more likely to have a concordance of NAFLD compared to couples with both a lower educational level and no abdominal obesity, respectively (p < 0.05). Conclusion: Our results indicated that health care professionals should bear in mind the marked spousal concordance with respect to risk factors and NAFLD for the prevention and early detection of the highly prevalent disease in older Chinese adults.
C1 [Yuan, Xueli; Ni, Wenqing; Sun, Yuanying; Zhang, Hongmin; Zhang, Yan; Xu, Jian] Shenzhen Ctr Chron Dis Control, Dept Elderly Hlth Management, Shenzhen 518020, Peoples R China.
   [Liu, Wei; Yin, Peng] Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommunicable Dis Control & Pre, Beijing 100050, Peoples R China.
C3 Chinese Center for Disease Control & Prevention
RP Xu, J (corresponding author), Shenzhen Ctr Chron Dis Control, Dept Elderly Hlth Management, Shenzhen 518020, Peoples R China.; Yin, P (corresponding author), Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommunicable Dis Control & Pre, Beijing 100050, Peoples R China.
EM yinpeng@ncncd.chinacdc.cn; anniexu73@126.com
RI xu, jian/GQQ-4903-2022; ni, wenqing/ABE-4730-2020; Yin,
   Peng/AFP-5157-2022
OI Liu, Wei/0000-0002-1737-8013
CR Abbafati C, 2020, LANCET, V396, P1204
   [Anonymous], 2019, WORLD POPULATION PRO
   Anstee QM, 2013, NAT REV GASTRO HEPAT, V10, P330, DOI 10.1038/nrgastro.2013.41
   Ayotte BJ, 2010, J GERONTOL B-PSYCHOL, V65, P438, DOI 10.1093/geronb/gbq033
   Barzin M, 2013, PEDIATR OBES, V8, P170, DOI 10.1111/j.2047-6310.2012.00102.x
   Bertschi IC, 2021, FRONT PSYCHOL, V12, DOI 10.3389/fpsyg.2021.624609
   Bookwala J, 1996, PSYCHOL AGING, V11, P582, DOI 10.1037/0882-7974.11.4.582
   Chalasani N, 2012, GASTROENTEROLOGY, V142, P1592, DOI 10.1053/j.gastro.2012.04.001
   Datta A, 2021, PLOS COMPUT BIOL, V17, DOI 10.1371/journal.pcbi.1009053
   Day CP, 2006, CLIN MED, V6, P19, DOI 10.7861/clinmedicine.6-1-19
   Di Castelnuovo A, 2009, AM J EPIDEMIOL, V169, P1, DOI 10.1093/aje/kwn234
   Estes C, 2018, J HEPATOL, V69, P896, DOI 10.1016/j.jhep.2018.05.036
   Frith J, 2009, GERONTOLOGY, V55, P607, DOI 10.1159/000235677
   Han Y., 2020, GHJ, V4, P11, DOI [https://doi.org/10.1016/j.glohj.2020.01.002, DOI 10.1016/J.GLOHJ.2020.01.002]
   Hoppmann C, 2009, GERONTOLOGY, V55, P449, DOI 10.1159/000211948
   Hu W, 2020, ANN ENDOCRINOL-PARIS, V81, P561, DOI 10.1016/j.ando.2020.07.1109
   Huang T, 2020, INTERN MED J, V50, P1038, DOI 10.1111/imj.14709
   Jun SY, 2020, KOREAN J FAM MED, V41, P183, DOI 10.4082/kjfm.18.0104
   Kähönen E, 2021, BLOOD PRESSURE, V30, P367, DOI 10.1080/08037051.2021.1980372
   Kang S, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17124574
   Kechagias S, 2020, METABOLISM, V111, DOI 10.1016/j.metabol.2020.154183
   Kim HC, 2006, ANN EPIDEMIOL, V16, P292, DOI 10.1016/j.annepidem.2005.07.052
   Kim Y, 2018, GERONTOLOGIST, V58, P1044, DOI 10.1093/geront/gnx132
   Li KK, 2013, J GERONTOL B-PSYCHOL, V68, P794, DOI 10.1093/geronb/gbt068
   Liao J, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18062886
   Montoya RM, 2008, J SOC PERS RELAT, V25, P889, DOI 10.1177/0265407508096700
   National Workshop on Fatty Liver and Alcoholic Liver Disease Chinese Society of Hepatology Chinese Medical Association, 2018, Zhonghua Gan Zang Bing Za Zhi, V26, P195, DOI 10.3760/cma.j.issn.1007-3418.2018.03.008
   Ni WQ, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2020-044892
   Norton MC, 2010, J AM GERIATR SOC, V58, P895, DOI 10.1111/j.1532-5415.2010.02806.x
   Office of the Leading Group of the State Council for the Seventh National Population Census, 2021, Major Figures on 2020 Population Census of China
   Powell EE, 2021, LANCET, V397, P2212, DOI 10.1016/S0140-6736(20)32511-3
   Read S, 2011, SOC PSYCH PSYCH EPID, V46, P331, DOI 10.1007/s00127-010-0205-3
   Retnakaran R, 2021, JAMA NETW OPEN, V4, DOI 10.1001/jamanetworkopen.2021.40578
   Schulz R, 2008, AM J NURS, V108, P23, DOI 10.1097/01.NAJ.0000336406.45248.4c
   Shih DP, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113332
   Stimpson Jim P, 2005, Prev Chronic Dis, V2, pA07
   Sun JH, 2016, AM J EPIDEMIOL, V184, P400, DOI 10.1093/aje/kwv330
   Valle G, 2013, J AGING HEALTH, V25, P1121, DOI 10.1177/0898264313494800
   Wang JW, 2021, JAMA NETW OPEN, V4, DOI 10.1001/jamanetworkopen.2021.25577
   Watanabe T, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2019-036281
   Xin Y, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17113977
   Younossi Z, 2018, NAT REV GASTRO HEPAT, V15, P11, DOI 10.1038/nrgastro.2017.109
   Zhou F, 2019, HEPATOLOGY, V70, P1119, DOI 10.1002/hep.30702
   Zhou JH, 2020, HEPATOLOGY, V71, P1851, DOI 10.1002/hep.31150
NR 44
TC 4
Z9 4
U1 2
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD JAN
PY 2023
VL 20
IS 2
AR 1426
DI 10.3390/ijerph20021426
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 7Y9RK
UT WOS:000915206500001
PM 36674180
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mirmira, RG
   Kulkarni, RN
   Xu, PW
   Drossos, T
   Varady, K
   Knutson, KL
   Reutrakul, S
   Martyn-Nemeth, P
   Sargis, RM
   Wallia, A
   Tuchman, AM
   Weissberg-Benchell, J
   Danielson, KK
   Oakes, SA
   Thomas, CC
   Layden, BT
   May, SC
   Hoffmann, MB
   Gatta, E
   Solway, J
   Philipson, LH
AF Mirmira, Raghavendra G.
   Kulkarni, Rohit N.
   Xu, Pingwen
   Drossos, Tina
   Varady, Krista
   Knutson, Kristen L.
   Reutrakul, Sirimon
   Martyn-Nemeth, Pamela
   Sargis, Robert M.
   Wallia, Amisha
   Tuchman, Arleen M.
   Weissberg-Benchell, Jill
   Danielson, Kirstie K.
   Oakes, Scott A.
   Thomas, Celeste C.
   Layden, Brian T.
   May, Sarah C.
   Burbea Hoffmann, Michelle
   Gatta, Eleonora
   Solway, Julian
   Philipson, Louis H.
TI Stress and human health in diabetes: A report from the 19<SUP>th</SUP>
   Chicago Biomedical Consortium symposium
SO JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
LA English
DT Article
DE Diabetes; stress; beta cells; metabolic syndrome; diabetes technology;
   healthcare; community
ID ENDOCRINE-DISRUPTING CHEMICALS; ESTROGEN-RECEPTOR-ALPHA; SLEEP
   EXTENSION; INSULIN SENSITIVITY; GLYCEMIC CONTROL; BODY-WEIGHT; OBESITY;
   ADULTS; ASSOCIATION; NEURONS
AB Stress and diabetes coexist in a vicious cycle. Different types of stress lead to diabetes, while diabetes itself is a major life stressor. This was the focus of the Chicago Biomedical Consortium's 19th annual symposium, "Stress and Human Health: Diabetes," in November 2022. There, researchers primarily from the Chicago area met to explore how different sources of stress - from the cells to the community - impact diabetes outcomes. Presenters discussed the consequences of stress arising from mutant proteins, obesity, sleep disturbances, environmental pollutants, COVID-19, and racial and socioeconomic disparities. This symposium showcased the latest diabetes research and highlighted promising new treatment approaches for mitigating stress in diabetes.
C1 [Mirmira, Raghavendra G.; Thomas, Celeste C.; May, Sarah C.] Univ Chicago, Kovler Diabet Ctr, Dept Med, Chicago, IL USA.
   [Kulkarni, Rohit N.] Harvard Stem Cell Inst, Joslin Diabet Ctr, Beth Israel Deaconess Med Ctr, Dept Med,Islet Cell & Regenerat Biol, Boston, MA USA.
   [Xu, Pingwen; Reutrakul, Sirimon; Sargis, Robert M.; Danielson, Kirstie K.] Univ Illinois, Dept Med, Div Endocrinol Diabet & Metab, Chicago, IL USA.
   [Drossos, Tina] Univ Chicago, Pritzker Sch Med, Dept Psychiat & Behav Neurosci, Chicago, IL USA.
   [Varady, Krista] Univ Illinois, Dept Kinesiol & Nutr, Chicago, IL USA.
   [Knutson, Kristen L.] Northwestern Univ, Ctr Circadian & Sleep Med, Feinberg Sch Med, Dept Neurol, Chicago, IL USA.
   [Martyn-Nemeth, Pamela] Univ Illinois, Dept Biobehav Nursing Sci, Coll Nursing, Chicago, IL USA.
   [Sargis, Robert M.] Jesse Brown VA Med Ctr, Dept Med, Sect Endocrinol Diabet & Metab, Chicago, IL USA.
   [Wallia, Amisha] Northwestern Univ, Feinberg Sch Med, Dept Med, Div Endocrinol Metab & Mol Med, Chicago, IL USA.
   [Tuchman, Arleen M.] Vanderbilt Univ, Dept Hist, Nashville, TN USA.
   [Weissberg-Benchell, Jill] Northwestern Univ, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med, Dept Psychiat & Behav Sci, Chicago, IL USA.
   [Oakes, Scott A.] Univ Chicago, Dept Pathol, Chicago, IL USA.
   [Layden, Brian T.] Univ Chicago, Sect Adult & Pediat Endocrinol Diabet & Metab, Chicago, IL USA.
   [Burbea Hoffmann, Michelle; Gatta, Eleonora] Chicago Biomed Consortium, Evanston, IL USA.
   [Solway, Julian] Univ Chicago, Dept Med, Chicago, IL USA.
   [Philipson, Louis H.] Univ Chicago, Dept Med & Pediat, Sect Adult & Pediat Endocrinol Diabet & Metab, Chicago, IL 60637 USA.
C3 University of Chicago; Harvard University; Harvard University Medical
   Affiliates; Joslin Diabetes Center, Inc.; Beth Israel Deaconess Medical
   Center; University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of Chicago;
   University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; Northwestern University;
   Feinberg School of Medicine; University of Illinois System; University
   of Illinois Chicago; University of Illinois Chicago Hospital; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Jesse Brown VA Medical Center; Northwestern University; Feinberg School
   of Medicine; Vanderbilt University; Ann & Robert H. Lurie Children's
   Hospital of Chicago; Northwestern University; Feinberg School of
   Medicine; University of Chicago; University of Chicago; University of
   Chicago; University of Chicago
RP Philipson, LH (corresponding author), Univ Chicago, Dept Med & Pediat, Sect Adult & Pediat Endocrinol Diabet & Metab, Chicago, IL 60637 USA.
EM l-philipson@uchicago.edu
RI Mirmira, Raghavendra/AAD-7592-2020; Danielson, Kirstie/C-4134-2013;
   Martyn-Nemeth, Pamela/JLM-9620-2023; Xu, Pingwen/GRR-9137-2022
OI Knutson, Kristen/0000-0002-2751-6168; Reutrakul,
   Sirimon/0000-0002-0686-1069; May, Sarah/0000-0003-4567-7480
FU Chicago Biomedical Consortium; Searle Funds at The Chicago Community
   Trust; Chicago Center for Diabetes Translation Research [NIDDK P30
   DK092949]; Dean's Office of the Biological Sciences Division of the
   University of Chicago; University of Illinois Chicago [CCTS
   UL1TR002003]; NIH/NIDDK [R01DK121726]; National Institutes of Health
   [R01 ES028879, R21 ES030884, P30 ES027792, UL1 TR002003]; NIDDK [RO1
   67536, UO1 DK135095]; NIH [R01 DK123098, R01CA219815, R01EY027810,
   U01DK127786]
FX This symposium was funded by the Chicago Biomedical Consortium with
   support from the Searle Funds at The Chicago Community Trust. PMN is
   funded by the Chicago Center for Diabetes Translation Research(NIDDK P30
   DK092949); the Dean's Office of the Biological Sciences Division of the
   University of Chicago, the University of Illinois Chicago (Grant No.
   CCTS UL1TR002003) and NIH/NIDDK, R01DK121726. RMS has been supported by
   the National Institutes of Health (R01 ES028879, R21 ES030884, P30
   ES027792, and UL1 TR002003). RNK is supported by NIDDK RO1 67536 and UO1
   DK135095. PX is supported by NIH R01 DK123098. SAO is funded by
   R01CA219815, R01EY027810, U01DK127786. RMS: The views expressed in this
   article are those of the authors and do not necessarily reflect the
   position or policy of the Department of Veterans Affairs or the United
   States Government.
CR ADCES, ADCES7 Self-Care BehaviorsThe Framework for Optimal Self-Management
   Al Khatib HK, 2018, AM J CLIN NUTR, V107, P43, DOI 10.1093/ajcn/nqx030
   Alharthi SK, 2021, DIABETES RES CLIN PR, V173, DOI 10.1016/j.diabres.2021.108682
   Amer Diabet Assoc, 2012, DIABETES CARE, V35, pS64, DOI 10.2337/dc12-S064
   Anderson ES, 2019, AM J PUBLIC HEALTH, V109, P270, DOI 10.2105/AJPH.2018.304799
   [Anonymous], 2022, National Diabetes Statistics Report| Diabetes| CDC
   Baron KG, 2021, SLEEP MED REV, V60, DOI 10.1016/j.smrv.2021.101532
   Basile G, 2023, CELL METAB, V35, DOI 10.1016/j.cmet.2023.05.007
   BRYANT RW, 1982, J BIOL CHEM, V257, P6050
   Cao XH, 2014, J CLIN INVEST, V124, P4351, DOI 10.1172/JCI74726
   Catenacci VA, 2016, OBESITY, V24, P1874, DOI 10.1002/oby.21581
   CDC. Centers for Disease Control and Prevention, 2022, Diabetes Report Card
   CDC. Centers for Disease Control and Prevention, 2022, Diabetes Data and Statistics
   Chaput JP, 2023, NAT REV ENDOCRINOL, V19, P82, DOI 10.1038/s41574-022-00747-7
   Chen HH, 2009, AM J CLIN NUTR, V90, P255, DOI 10.3945/ajcn.2009.25914
   Chontong S, 2016, J SLEEP RES, V25, P438, DOI 10.1111/jsr.12393
   Chow LS, 2020, OBESITY, V28, P860, DOI [10.1002/oby.22756, 10.1002/oby.22785]
   Cienfuegos S, 2020, CELL METAB, V32, P366, DOI 10.1016/j.cmet.2020.06.018
   Coccaro EF, 2022, PRIM CARE DIABETES, V16, P381, DOI 10.1016/j.pcd.2022.03.002
   Dalle Grave R, 2020, BIOPSYCHOSOC MED, V14, DOI 10.1186/s13030-020-00177-9
   Dindo L, 2017, NEUROTHERAPEUTICS, V14, P546, DOI 10.1007/s13311-017-0521-3
   Donga E, 2010, DIABETES CARE, V33, P1573, DOI 10.2337/dc09-2317
   El Ouaamari A, 2016, CELL METAB, V23, P194, DOI 10.1016/j.cmet.2015.12.001
   Ellis DA, 2021, PEDIATR DIABETES, V22, P511, DOI 10.1111/pedi.13176
   Eshghinia S, 2013, J DIABETES METAB DIS, V12, DOI 10.1186/2251-6581-12-4
   Fegan-Bohm K, 2020, PEDIATR DIABETES, V21, P1362, DOI 10.1111/pedi.13108
   Fortmann AL, 2020, DIABETES CARE, V43, P2873, DOI 10.2337/dc20-1016
   Gabel Kelsey, 2018, Nutr Healthy Aging, V4, P345, DOI 10.3233/NHA-170036
   Garofolo M, 2021, DIABETES RES CLIN PR, V180, DOI 10.1016/j.diabres.2021.109066
   Genco M., 2020, Journal of Clinical Endocrinology & Metabolism, V105, pe3822, DOI 10.1210/clinem/dgaa358
   Gonzalez JS, 2010, J COGN PSYCHOTHER, V24, P329, DOI 10.1891/0889-8391.24.4.329
   Gonzalez-Duque S, 2018, CELL METAB, V28, P946, DOI 10.1016/j.cmet.2018.07.007
   Gorasia DG, 2015, J PROTEOME RES, V14, P688, DOI 10.1021/pr500643h
   Gu JM, 2009, ACTA PHARMACOL SIN, V30, P1634, DOI 10.1038/aps.2009.169
   Hartescu I, 2018, Glucose tolerance following a 6-week sleep extension protocol in overweight short sleepers
   Hawk K, 2018, ADDICT SCI CLIN PRAC, V13, DOI 10.1186/s13722-018-0117-1
   Heilbronn LK, 2005, AM J CLIN NUTR, V81, P69
   Heindel JJ, 2017, REPROD TOXICOL, V68, P3, DOI 10.1016/j.reprotox.2016.10.001
   Herold KC, 2019, NEW ENGL J MED, V381, P603, DOI 10.1056/NEJMoa1902226
   Hill-Briggs F, 2021, DIABETES CARE, V44, P258, DOI 10.2337/dci20-0053
   Hng TM, 2016, BMJ OPEN DIAB RES CA, V4, DOI 10.1136/bmjdrc-2015-000191
   Hoddy KK, 2014, OBESITY, V22, P2524, DOI 10.1002/oby.20909
   Jagai JS, 2021, ENDOCR CONNECT, V10, P1018, DOI 10.1530/EC-21-0132
   Jagai JS, 2020, J DIABETES INVEST, V11, P315, DOI 10.1111/jdi.13152
   Kahraman S, 2022, NAT METAB, V4, P76, DOI 10.1038/s42255-021-00516-2
   Kalam F, 2019, OBES SCI PRACT, V5, P531, DOI 10.1002/osp4.367
   Karatsoreos IN, 2010, ENDOCRINOLOGY, V151, P2117, DOI 10.1210/en.2009-1436
   Kassem DH, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00450
   Khunti K, 2022, LANCET DIABETES ENDO, V10, P890, DOI 10.1016/S2213-8587(22)00278-9
   Knutson KL, 2008, ANN NY ACAD SCI, V1129, P287, DOI 10.1196/annals.1417.033
   Kulkarni A, 2022, METABOLITES, V12, DOI 10.3390/metabo12040344
   Leitner DR, 2017, OBESITY FACTS, V10, P483, DOI 10.1159/000480525
   Leproult R, 2015, SLEEP, V38, P708, DOI 10.5665/sleep.4660
   Lin J, 2017, J PUBLIC HEALTH MAN, V23, P264, DOI [10.1097/phh.0000000000000448, 10.1097/PHH.0000000000000448]
   Lin XL, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-71908-9
   Lowe DA, 2020, JAMA INTERN MED, V180, P1491, DOI 10.1001/jamainternmed.2020.4153
   Marre ML, 2018, DIABETES, V67, P1356, DOI 10.2337/db17-1166
   de Morentin PBM, 2014, CELL METAB, V20, P41, DOI 10.1016/j.cmet.2014.03.031
   Martyn-Nemeth P, 2023, SCI DIABETES SELF-MA, V49, P11, DOI 10.1177/26350106221136495
   Martyn-Nemeth P, 2019, CLIN NURS RES, V28, P947, DOI 10.1177/1054773818774702
   Mauvais-Jarvis F, 2013, ENDOCR REV, V34, P309, DOI 10.1210/er.2012-1055
   McEwen Bruce S, 2006, Dialogues Clin Neurosci, V8, P367
   Mimoto Mizuho S, 2017, Curr Environ Health Rep, V4, P208, DOI 10.1007/s40572-017-0137-0
   Mohajer N, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.787580
   Moore PC, 2019, J CLIN INVEST, V129, P4676, DOI 10.1172/JCI129961
   Moro T, 2016, J TRANSL MED, V14, DOI 10.1186/s12967-016-1044-0
   Neel BA, 2011, DIABETES, V60, P1838, DOI 10.2337/db11-0153
   Okura T, 2003, INT J OBESITY, V27, P1020, DOI 10.1038/sj.ijo.0802378
   Orban T, 2011, LANCET, V378, P412, DOI 10.1016/S0140-6736(11)60886-6
   Park M, 2013, GEN HOSP PSYCHIAT, V35, P217, DOI 10.1016/j.genhosppsych.2013.01.006
   Parvaresh A, 2019, COMPLEMENT THER MED, V47, DOI 10.1016/j.ctim.2019.08.021
   Pepera G, 2022, REV CARDIOVASC MED, V23, DOI 10.31083/j.rcm2301028
   Pescovitz MD, 2009, NEW ENGL J MED, V361, P2143, DOI 10.1056/NEJMoa0904452
   Pettus JH, 2019, DIABETES CARE, V42, P2220, DOI 10.2337/dc19-0830
   Pineros AR, 2022, CELL REP, V39, DOI 10.1016/j.celrep.2022.111011
   Rangaraj VR, 2016, SLEEP MED, V18, P19, DOI 10.1016/j.sleep.2015.02.535
   Reutrakul S, 2022, PILOT FEASIBILITY ST, V8, DOI 10.1186/s40814-022-01076-2
   Reutrakul S, 2016, SLEEP MED, V23, P26, DOI 10.1016/j.sleep.2016.03.019
   Roep BO, 2021, NAT REV ENDOCRINOL, V17, P150, DOI 10.1038/s41574-020-00443-4
   Ruiz D, 2018, DIABETES CARE, V41, P193, DOI 10.2337/dc16-2765
   Sargis R.M., 2015, Endocrine Disruptors, V3, DOI DOI 10.1080/23273747.2015.1080788
   Sargis RM, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00033
   Schipper SBJ, 2021, DIABETOLOGIA, V64, P2367, DOI 10.1007/s00125-021-05541-0
   Schulz MC, 2021, ADV PHARMACOL, V92, P419, DOI 10.1016/bs.apha.2021.04.002
   Shaikh S, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-0993-5
   Sherry N, 2011, LANCET, V378, P487, DOI 10.1016/S0140-6736(11)60931-8
   Simon GE, 2006, ARCH GEN PSYCHIAT, V63, P824, DOI 10.1001/archpsyc.63.7.824
   So-ngern A, 2019, J CLIN SLEEP MED, V15, P711, DOI 10.5664/jcsm.7758
   Spanakis Elias K, 2018, J Diabetes Sci Technol, V12, P20, DOI 10.1177/1932296817748964
   Stekovic S, 2019, CELL METAB, V30, P462, DOI 10.1016/j.cmet.2019.07.016
   STOP Obesity Alliance | Milken Institute School of Public Health, Fast Facts - Mental Health and Obesity
   Strawbridge LM, 2015, HEALTH EDUC BEHAV, V42, P530, DOI 10.1177/1090198114566271
   Sutton EF, 2018, CELL METAB, V27, P1212, DOI 10.1016/j.cmet.2018.04.010
   Tersey SA, 2014, AMINO ACIDS, V46, P633, DOI 10.1007/s00726-013-1560-7
   Tinsley GM, 2019, AM J CLIN NUTR, V110, P628, DOI 10.1093/ajcn/nqz126
   Twigg SM, 2015, MED J AUSTRALIA, V202, P300, DOI 10.5694/mja14.01234
   Varady KA, 2021, ANNU REV NUTR, V41, P333, DOI 10.1146/annurev-nutr-052020-041327
   Varady KA, 2009, AM J CLIN NUTR, V90, P1138, DOI 10.3945/ajcn.2009.28380
   Vigersky RA, 2014, J CLIN ENDOCR METAB, V99, P3112, DOI 10.1210/jc.2014-2257
   Wallia A, 2020, CURR DIABETES REP, V20, DOI 10.1007/s11892-020-01366-0
   Wander PL, 2022, DIABETES CARE, V45, P782, DOI 10.2337/dc21-1686
   Weissberg-Benchell J, 2020, J CONSULT CLIN PSYCH, V88, P1019, DOI 10.1037/ccp0000608
   Xu PW, 2015, J CLIN INVEST, V125, P2861, DOI 10.1172/JCI80941
   Xu Y, 2011, CELL METAB, V14, P453, DOI 10.1016/j.cmet.2011.08.009
   Ye H, 2022, SCI ADV, V8, DOI 10.1126/sciadv.abk0185
   Zhang P, 2016, BMC FAM PRACT, V17, DOI 10.1186/s12875-016-0435-x
   Zhang Z, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-20050-1
NR 107
TC 0
Z9 0
U1 1
U2 4
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
EI 2059-8661
J9 J CLIN TRANSL SCI
JI J. Clin. Transl. Sci.
PD NOV 20
PY 2023
VL 7
IS 1
AR e263
DI 10.1017/cts.2023.646
PG 8
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA CJ5X6
UT WOS:001124909700001
PM 38229904
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Janczura, M
   Rosa, R
   Dropinski, J
   Gielicz, A
   Stanisz, A
   Kotula-Horowitz, K
   Domagala, T
AF Janczura, Miroslaw
   Rosa, Rafal
   Dropinski, Jerzy
   Gielicz, Anna
   Stanisz, Andrzej
   Kotula-Horowitz, Katarzyna
   Domagala, Teresa
TI The Associations of Perceived and Oxidative Stress with Hypertension in
   a Cohort of Police Officers
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE metabolic syndrome; obesity; hypertension; perceived stress; oxidative
   stress; physical activity
ID METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY;
   BLOOD-PRESSURE; MYOCARDIAL-INFARCTION; RISK-FACTORS; 8-ISOPROSTANE;
   F-2-ISOPROSTANES; MECHANISMS; COUNTRIES
AB Purpose: Associations between perceived stress and oxidative stress marker and metabolic syndrome (MetS) components were investigated in a cohort of police officers.
   Methods: Cross-sectional data from a cohort of non-diabetic subjects (n=233; 19F), median [interquartile range] age 50 [37-44] years, were analysed. MetS was construed in line with International Diabetes Federation (IDF) criteria and perceived stress with Cohen's 10-item Perceived Stress Scale. Plasma oxidative stress marker (free 8-iso-prostaglandin F-2 alpha 8-iso-PGF(2 alpha)), presence of coronary plaque, carotid artery intima-media thickness (cIMT), and physical activity level were also determined.
   Results: Obesity was established in 100 (42.92%), hypertension in 111 (47.64), whereas MetS was identified in 104 (44.63%) of the study subjects. A significant difference (p=0.003) in plasma 8-iso-PGF(2 alpha) level, depending on the MetS components status, was noted. The associations of perceived stress with plasma 8-iso-PGF(2 alpha) level and the select study variables were gender-specific. In multivariate analysis (adjusted for age and current smoking), positive associations of plasma 8-iso-PGF(2 alpha) levels with PSS score (B=0.108, 95% CI [0.008, 0.209], p=0.03) and systolic blood pressure (B=0.029, 95% CI [0.003, 0.057], p=0.02) in men only were established. Both the perceived stress (OR 1.101, 95% CI [1.001-1.202], p=0.03) and plasma 8-iso-PGF(2 alpha) levels (OR 1.223, 95% CI [1.046-1.432], p=0.01) impacted the prevalence of hypertension. Out of the MetS components, the effect of waist circumference (OR=1.138, 95% CI [1.064-1.218], p=0.0001) and glucose (B=2.696, 95% CI [1.081-6.725], p=0.03) were also encountered. No such associations were noted in women, though, neither in univariate nor in multivariate analyses. The prevalence of coronary plaque (0.001), obesity (p<0.001), hypertension (p<0.001) and median cIMT value (p=0.005), as well as leisure-time (p=0.04) and total walking physical activity (p=0.03), differed significantly between the subgroups stratified by MetS components status.
   Conclusion: Both the perceived and oxidative stress were found instrumental in promoting hypertension in a cohort of police officers under study, whereas all study outcomes were conclusively gender-related.
C1 [Janczura, Miroslaw] Jagiellonian Univ, Fac Hlth Sci, Sch Med, Krakow, Poland.
   [Rosa, Rafal] Minist Interior & Adm, Dept Anesthesiol & Intens Care, Hlth Care Ctr, Krakow, Poland.
   [Dropinski, Jerzy; Gielicz, Anna] Jagiellonian Univ, Dept Internal Med, Sch Med, Krakow, Poland.
   [Stanisz, Andrzej] Jagiellonian Univ, Dept Bioinformat & Telemed, Sch Med, Krakow, Poland.
   [Kotula-Horowitz, Katarzyna] Minist Interior & Adm, Hlth Care Ctr, Dept Internal Med, Krakow, Poland.
   [Domagala, Teresa] Jagiellonian Univ, Dept Med Biochem, Sch Med, Krowoderska 68-11, PL-31158 Krakow, Poland.
C3 Jagiellonian University; Jagiellonian University; Jagiellonian
   University; Jagiellonian University
RP Domagala, T (corresponding author), Jagiellonian Univ, Dept Med Biochem, Sch Med, Krowoderska 68-11, PL-31158 Krakow, Poland.
EM domagala32@yahoo.com
RI Gielicz, Anna/MTC-4051-2025; Janczura, Miroslaw/HSE-9726-2023
OI Janczura, Miroslaw/0000-0001-8485-0683
CR Ainsworth BE, 2011, MED SCI SPORT EXER, V43, P1575, DOI 10.1249/MSS.0b013e31821ece12
   Andreou E, 2011, INT J ENV RES PUB HE, V8, P3287, DOI 10.3390/ijerph8083287
   Black CN, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/7530820
   Block JP, 2009, AM J EPIDEMIOL, V170, P181, DOI 10.1093/aje/kwp104
   de Faria APC, 2014, CLIN CHIM ACTA, V433, P179, DOI 10.1016/j.cca.2014.03.009
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   COHEN Y, 1988, J CHEM SOC PERK T 2, P31, DOI 10.1039/p29880000031
   Ercan H, 2016, METAB SYNDR RELAT D, V14, P318, DOI 10.1089/met.2016.0011
   Franco OH, 2009, CIRCULATION, V120, P1943, DOI 10.1161/CIRCULATIONAHA.109.855817
   Fujita K, 2006, CIRC J, V70, P1437, DOI 10.1253/circj.70.1437
   Garbarino S, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0224259
   Garbarino S, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0144318
   Gendron P, 2019, ARCH ENVIRON OCCUP H, V74, P331, DOI 10.1080/19338244.2018.1472063
   Ghiadoni L, 2003, HYPERTENSION, V41, P1281, DOI 10.1161/01.HYP.0000070956.57418.22
   Grande MT, 2011, FREE RADICAL BIO MED, V51, P1831, DOI 10.1016/j.freeradbiomed.2011.08.014
   Hall JE, 2015, CIRC RES, V116, P991, DOI 10.1161/CIRCRESAHA.116.305697
   Hamza SM, 2014, FRONT PHYSIOL, V5, DOI 10.3389/fphys.2014.00292
   Hartley Tara A, 2011, Int J Emerg Ment Health, V13, P243
   Horbal SR, 2016, AM J HYPERTENS, V29, P814, DOI 10.1093/ajh/hpw007
   Janczura M, 2020, DIABETOL METAB SYNDR, V12, DOI 10.1186/s13098-020-00566-8
   Janczura M, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0133750
   Juczynski Z., 2009, Pracownia Testow Psychologicznych, Polskie Towarzystwo Psychologiczne
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Kozey S, 2010, J PHYS ACT HEALTH, V7, P508, DOI 10.1123/jpah.7.4.508
   Landmesser U, 2002, HYPERTENSION, V40, P511, DOI 10.1161/01.HYP.0000032100.23772.98
   Lawes CMM, 2008, LANCET, V371, P1513, DOI 10.1016/S0140-6736(08)60655-8
   Lee IM, 2012, LANCET, V380, P219, DOI 10.1016/S0140-6736(12)61031-9
   Li J, 2012, INT J ENV RES PUB HE, V9, P391, DOI 10.3390/ijerph9020391
   Ma CC, 2011, J OCCUP ENVIRON MED, V53, P1030, DOI 10.1097/JOM.0b013e31822589f9
   Magnavita N, 2018, INT ARCH OCC ENV HEA, V91, P377, DOI 10.1007/s00420-018-1290-y
   Magnavita N, 2017, INT J ENV RES PUB HE, V14, DOI 10.3390/ijerph14111347
   Melton CD, 2017, ANN EPIDEMIOL, V27, P391, DOI 10.1016/j.annepidem.2017.05.005
   Montezano AC, 2012, CAN J CARDIOL, V28, P288, DOI 10.1016/j.cjca.2012.01.017
   Morrow JD, 1999, METHOD ENZYMOL, V300, P3
   Ninomiya JK, 2004, CIRCULATION, V109, P42, DOI 10.1161/01.CIR.0000108926.04022.0C
   O'Donnell MJ, 2010, LANCET, V376, P112, DOI 10.1016/S0140-6736(10)60834-3
   Petersen CB, 2014, PREV MED, V69, P5, DOI 10.1016/j.ypmed.2014.08.022
   Ramakrishnan Jayalakshmy, 2013, J Cardiovasc Dis Res, V4, P112, DOI 10.1016/j.jcdr.2013.05.002
   Ramey SL, 2011, AAOHN J, V59, P221, DOI 10.3928/08910162-20110418-02
   Ramey SL, 2009, AAOHN J, V57, P448, DOI 10.3928/08910162-20091019-02
   Rodrigo R, 2007, HYPERTENS RES, V30, P1159, DOI 10.1291/hypres.30.1159
   Romeo GR, 2012, ARTERIOSCL THROM VAS, V32, P1771, DOI 10.1161/ATVBAHA.111.241869
   Sametz W, 1999, EUR J PHARMACOL, V378, P47, DOI 10.1016/S0014-2999(99)00437-9
   Scuteri A, 2015, EUR J PREV CARDIOL, V22, P486, DOI 10.1177/2047487314525529
   Seet RCS, 2010, DIABETES CARE, V33, P1140, DOI 10.2337/dc09-2124
   Shiozaki M, 2017, IND HEALTH, V55, P369, DOI 10.2486/indhealth.2016-0179
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Song L, 2009, NEUROCHEM RES, V34, P739, DOI 10.1007/s11064-008-9838-y
   Spiers JG, 2015, FRONT NEUROSCI-SWITZ, V8, DOI 10.3389/fnins.2014.00456
   Spruill TM, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.119.012139
   Steptoe A, 2004, J HYPERTENS, V22, P915, DOI 10.1097/00004872-200405000-00012
   Steptoe A, 2000, ANN MED, V32, P371, DOI 10.3109/07853890008995940
   TAKAHASHI K, 1992, J CLIN INVEST, V90, P136, DOI 10.1172/JCI115826
   Tharkar Shabana, 2008, J Assoc Physicians India, V56, P845
   Touyz RM, 2011, HYPERTENS RES, V34, P5, DOI 10.1038/hr.2010.201
   Wiernik E, 2013, HYPERTENSION, V61, P571, DOI 10.1161/HYPERTENSIONAHA.111.00302
   Williams B., 2018, Journal of Hypertension, DOI [DOI 10.1093/EURHEARTJ/EHY339, 10.1097/HJH.0000000000001940, DOI 10.1097/HJH.0000000000001940]
   Yusuf S, 2000, NEW ENGL J MED, V342, P154, DOI 10.1056/NEJM200001203420302
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
   Zafir A, 2009, STRESS, V12, P167, DOI 10.1080/10253890802234168
   Zhang JY, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000017306
NR 61
TC 6
Z9 6
U1 0
U2 2
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2021
VL 14
BP 1783
EP 1797
DI 10.2147/DMSO.S298596
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA RU0TG
UT WOS:000644864700001
PM 33953580
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wang, X
   Zhang, ZF
   Zheng, GH
   Wang, AM
   Sun, CH
   Qin, SP
   Zhuang, J
   Lu, J
   Ma, DF
   Zheng, YL
AF Wang, Xin
   Zhang, Zi-Feng
   Zheng, Gui-Hong
   Wang, Ai-Min
   Sun, Chun-Hui
   Qin, Su-Ping
   Zhuang, Juan
   Lu, Jun
   Ma, Dai-Fu
   Zheng, Yuan-Lin
TI The Inhibitory Effects of Purple Sweet Potato Color on Hepatic
   Inflammation Is Associated with Restoration of NAD<SUP>+</SUP> Levels
   and Attenuation of NLRP3 Inflammasome Activation in
   High-Fat-Diet-Treated Mice
SO MOLECULES
LA English
DT Article
DE purple sweet potato color; hepatic inflammation; NAD(+); NLRP3
   inflammasome; high-fat diet
ID ENDOPLASMIC-RETICULUM STRESS; ER STRESS; OXIDATIVE STRESS; NICOTINAMIDE
   RIBOSIDE; ANTIOXIDANT ACTIVITY; INSULIN SENSITIVITY; GUT MICROBIOTA;
   ADIPOSE-TISSUE; D-GALACTOSE; LIVER
AB Purple sweet potato color (PSPC), a class of naturally occurring anthocyanins, exhibits beneficial effects on metabolic syndrome. Sustained inflammation plays a crucial role in the pathogenesis of metabolic syndrome. Here we explored the effects of PSPC on high-fat diet (HFD)-induced hepatic inflammation and the mechanisms underlying these effects. Mice were divided into four groups: Control group, HFD group, HFD + PSPC group, and PSPC group. PSPC was administered by daily oral gavage at doses of 700 mg/kg/day for 20 weeks. Nicotinamide riboside (NR) was used to increase NAD(+) levels. Our results showed that PSPC effectively ameliorated obesity and liver injuries in HFD-fed mice. Moreover, PSPC notably blocked hepatic oxidative stress in HFD-treated mice. Furthermore, PSPC dramatically restored NAD(+) level to abate endoplasmic reticulum stress (ER stress) in HFD-treated mouse livers, which was confirmed by NR treatment. Consequently, PSPC remarkably suppressed the nuclear factor-kappa B (NF-kappa B) p65 nuclear translocation and nucleotide oligomerization domain protein1/2 (NOD1/2) signaling in HFD-treated mouse livers. Thereby, PSPC markedly diminished the NLR family, pyrin domain containing 3 (NLRP3) inflammasome activation, ultimately lowering the expressions of inflammation-related genes in HFD-treated mouse livers. In summary, PSPC protected against HFD-induced hepatic inflammation by boosting NAD(+) level to inhibit NLRP3 inflammasome activation.
C1 [Wang, Xin; Zhang, Zi-Feng; Zheng, Gui-Hong; Wang, Ai-Min; Sun, Chun-Hui; Qin, Su-Ping; Zhuang, Juan; Lu, Jun; Zheng, Yuan-Lin] Jiangsu Normal Univ, Sch Life Sci, Key Lab Biotechnol Med Plants Jiangsu Prov, Xuzhou 221116, Peoples R China.
   [Wang, Xin; Ma, Dai-Fu] Jiangsu Xuzhou Sweetpotato Res Ctr, Key Lab Biol & Genet Improvement Sweetpotato, Minist Agr, Xuzhou 221131, Peoples R China.
C3 Jiangsu Normal University; Ministry of Agriculture & Rural Affairs;
   Jiangsu Academy of Agricultural Sciences
RP Zhang, ZF; Zheng, YL (corresponding author), Jiangsu Normal Univ, Sch Life Sci, Key Lab Biotechnol Med Plants Jiangsu Prov, Xuzhou 221116, Peoples R China.
EM xznkywx@163.com; zhangzifengsuper@jsnu.edu.cn; 6020030110@jsnu.edu.cn;
   aiminwang@jsnu.edu.cn; 6020110036@jsnu.edu.cn; qinsuping1234@163.com;
   dajiangsky@163.com; lu-jun75@163.com; daifuma@163.com;
   ylzheng@jsnu.edu.cn
RI Lu, Jun/N-6109-2019
OI Lu, Jun/0000-0002-2801-5330
FU Priority Academic Program Development of Jiangsu Higher Education
   Institutions (PAPD); National Natural Science Foundation of China
   [81570531, 81571055]; China Agriculture Research System-sweetpotato
   [CARS-10]; Key Research and Development Plan of Jiangsu Province
   [BE2015313]; Scientific Research Support Project for Teachers with
   Doctor's Degrees [15XLR005]; Natural Science Foundation of Jiangsu
   Province [BK20131127]; Graduate Student Innovation Program of Jiangsu
   Province [KYZZ_0395, KYZZ16_0467]
FX This work is supported by the Priority Academic Program Development of
   Jiangsu Higher Education Institutions (PAPD); the National Natural
   Science Foundation of China (81570531, 81571055); the China Agriculture
   Research System-sweetpotato (CARS-10); the Key Research and Development
   Plan of Jiangsu Province (BE2015313); the Scientific Research Support
   Project for Teachers with Doctor's Degrees (15XLR005); Natural Science
   Foundation of Jiangsu Province (BK20131127); and the Graduate Student
   Innovation Program of Jiangsu Province (KYZZ_0395, KYZZ16_0467).
CR Aragonès G, 2016, SCI REP-UK, V6, DOI 10.1038/srep24977
   Boesten DMPHJ, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/894597
   Brun P, 2007, AM J PHYSIOL-GASTR L, V292, pG518, DOI 10.1152/ajpgi.00024.2006
   Cantó C, 2012, CELL METAB, V15, P838, DOI 10.1016/j.cmet.2012.04.022
   de Kreutzenberg SV, 2010, DIABETES, V59, P1006, DOI 10.2337/db09-1187
   Duparc T, 2017, GUT, V66, P620, DOI 10.1136/gutjnl-2015-310904
   Esatbeyoglu T, 2017, FOOD CHEM, V221, P447, DOI 10.1016/j.foodchem.2016.10.077
   Escande C, 2013, DIABETES, V62, P1084, DOI 10.2337/db12-1139
   Fang EF, 2014, CELL, V157, P882, DOI 10.1016/j.cell.2014.03.026
   Gariani K, 2017, J HEPATOL, V66, P132, DOI 10.1016/j.jhep.2016.08.024
   Gariani K, 2016, HEPATOLOGY, V63, P1190, DOI 10.1002/hep.28245
   Garten A, 2015, NAT REV ENDOCRINOL, V11, P535, DOI 10.1038/nrendo.2015.117
   Gerdts J, 2015, SCIENCE, V348, P453, DOI 10.1126/science.1258366
   Gueguen C, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0087367
   Han XJ, 2016, AGING CELL, V15, P416, DOI 10.1111/acel.12446
   Handa P, 2014, HEPATOLOGY, V60, P133, DOI 10.1002/hep.26946
   Jamar G., 2017, BIOFACTORS
   Jourdan T, 2013, NAT MED, V19, P1132, DOI 10.1038/nm.3265
   Ke BL, 2015, DIABETES, V64, P3355, DOI 10.2337/db15-0242
   Keestra-Gounder AM, 2016, NATURE, V532, P394, DOI 10.1038/nature17631
   Kraus D, 2014, NATURE, V508, P258, DOI 10.1038/nature13198
   Lee HM, 2013, DIABETES, V62, P194, DOI 10.2337/db12-0420
   Lerner AG, 2012, CELL METAB, V16, P250, DOI 10.1016/j.cmet.2012.07.007
   Leung C, 2016, NAT REV GASTRO HEPAT, V13, P412, DOI 10.1038/nrgastro.2016.85
   Li HL, 2012, AM J PHYSIOL-ENDOC M, V303, pE1234, DOI 10.1152/ajpendo.00198.2012
   Li JX, 2015, BBA-MOL CELL RES, V1853, P2929, DOI 10.1016/j.bbamcr.2015.09.003
   Li Y, 2015, TOXICOL APPL PHARM, V286, P53, DOI 10.1016/j.taap.2015.03.010
   Li YY, 2016, HEPATOLOGY, V63, P1860, DOI 10.1002/hep.28472
   Lu J, 2012, FREE RADICAL BIO MED, V52, P646, DOI 10.1016/j.freeradbiomed.2011.11.016
   Luccarini I, 2016, J ALZHEIMERS DIS, V54, P737, DOI 10.3233/JAD-160471
   Luo YW, 2016, AM J PHYSIOL-ENDOC M, V310, pE418, DOI 10.1152/ajpendo.00319.2015
   Menu P, 2012, CELL DEATH DIS, V3, DOI 10.1038/cddis.2011.132
   Módis K, 2012, BIOCHEM PHARMACOL, V83, P633, DOI 10.1016/j.bcp.2011.12.014
   Moreira LO, 2012, FRONT IMMUNOL, V3, DOI 10.3389/fimmu.2012.00328
   Morrison MC, 2016, INT J OBESITY, V40, P1416, DOI 10.1038/ijo.2016.74
   Mulder P, 2016, INT J OBESITY, V40, P675, DOI 10.1038/ijo.2015.226
   Ocampo A, 2013, HUM MOL GENET, V22, P1699, DOI 10.1093/hmg/ddt016
   Okin D, 2016, CELL, V165, P343, DOI 10.1016/j.cell.2016.02.023
   Park EC, 2014, GASTROENTEROLOGY, V147, P860, DOI 10.1053/j.gastro.2014.06.039
   Pirinen E, 2014, CELL METAB, V19, P1034, DOI 10.1016/j.cmet.2014.04.002
   Stromsdorfer KL, 2016, CELL REP, V16, P1851, DOI 10.1016/j.celrep.2016.07.027
   Trammell SAJ, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms12948
   Tsai PY, 2011, FREE RADICAL BIO MED, V51, P744, DOI 10.1016/j.freeradbiomed.2011.05.016
   Wang LL, 2016, J LIPID RES, V57, P1243, DOI 10.1194/jlr.M067397
   Wang YJ, 2010, NEUROCHEM INT, V56, P424, DOI 10.1016/j.neuint.2009.11.016
   Wu T, 2016, MOL NUTR FOOD RES, V60, P687, DOI 10.1002/mnfr.201500734
   Yan YQ, 2013, IMMUNITY, V38, P1154, DOI 10.1016/j.immuni.2013.05.015
   Yang SM, 2014, DIABETOLOGIA, V57, P424, DOI 10.1007/s00125-013-3115-6
   Yang SJ, 2014, METABOLISM, V63, P693, DOI 10.1016/j.metabol.2014.02.003
   Yoshino J, 2011, CELL METAB, V14, P528, DOI 10.1016/j.cmet.2011.08.014
   Zhang X, 2015, ANTIOXID REDOX SIGN, V22, P848, DOI 10.1089/ars.2014.5868
   Zhang ZF, 2014, BIOCHEM PHARMACOL, V91, P74, DOI 10.1016/j.bcp.2014.07.002
   Zhang ZF, 2013, J NUTR BIOCHEM, V24, P1008, DOI 10.1016/j.jnutbio.2012.07.009
   Zhang ZF, 2010, FOOD CHEM TOXICOL, V48, P2500, DOI 10.1016/j.fct.2010.06.023
   Zhang ZF, 2009, FOOD CHEM TOXICOL, V47, P496, DOI 10.1016/j.fct.2008.12.005
NR 55
TC 32
Z9 33
U1 1
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD AUG
PY 2017
VL 22
IS 8
AR 1315
DI 10.3390/molecules22081315
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA FF0PF
UT WOS:000408602900080
PM 28786950
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Cheng, X
   Guo, QY
   Ju, LH
   Gong, WY
   Wei, XQ
   Xu, XL
   Zhao, LY
   Fang, HY
AF Cheng, Xue
   Guo, Qiya
   Ju, Lahong
   Gong, Weiyi
   Wei, Xiaoqi
   Xu, Xiaoli
   Zhao, Liyun
   Fang, Hongyun
TI Association between sedentary behavior, screen time and metabolic
   syndrome among Chinese children and adolescents
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Sedentary time; Screen time; Metabolic syndrome; Children and
   adolescents; China
ID ABDOMINAL ADIPOSE-TISSUE; PHYSICAL-ACTIVITY; RISK-FACTORS; PREVALENCE;
   DEPRESSION; ANXIETY; HEALTH
AB BackgroundThe aim of the study was to investigate the relationship between sedentary behavior, screen time and MetS among Chinese children and adolescents aged 7-17 years. Data was obtained from the China National Nutrition and Health Surveillance of Children and Lactating Mothers in 2016-2017.MethodsData on sedentary time, screen time, and MetS indicators were obtained through physical and health questionnaires, anthropometric measurements, and clinical examinations. MetS was defined according to the Cook's criteria. Wilcoxon rank sum test and chi-square test were applied for comparisons of measurement data and counting data, respectively. The relationship between sedentary time, screen time, and MetS and its components was analyzed using a multivariate logistic regression model.ResultsThe prevalence of MetS among 7-17-year-old students in 2016-2017 was 5.45%. Compared to those with low sedentary behavior, in high sedentary behavior groups, the prevalence of abdominal obesity, high TG, low HDL-C, and MetS was high in boys, and the prevalence of abdominal obesity, high TG, hyperglycemia, and MetS was high in girls. Moreover, for those who reported >= 3 h/day of screen time, the prevalence of abdominal obesity, low HDL-C, and MetS was higher in boys, and the prevalence of abdominal obesity and MetS was higher in girls. After adjusting for confounding variables, the risks of abdominal obesity, high TG, low HDL-C, and MetS were higher in high-level sedentary time group, and the risks of abdominal obesity and MetS were 1.15 and 1.14 times higher for those who spent >= 3 h/day on screen time, respectively.ConclusionsThis study shows that high levels of sedentary time and screen time were associated with an increased likelihood of MetS among Chinese children and adolescents aged 7-17 years. Reducing sedentary behavior and screen time may contribute to the prevention of metabolic diseases.
C1 [Cheng, Xue; Guo, Qiya; Ju, Lahong; Gong, Weiyi; Wei, Xiaoqi; Xu, Xiaoli; Zhao, Liyun; Fang, Hongyun] Natl Inst Nutr & Hlth, Chinese Ctr Dis Control & Prevent, Beijing 100050, Peoples R China.
   [Ju, Lahong; Zhao, Liyun; Fang, Hongyun] Natl Inst Nutr & Hlth, Chinese Ctr Dis Control & Prevent, NHC Key Lab Trace Element Nutr, Beijing 100050, Peoples R China.
C3 Chinese Center for Disease Control & Prevention; Chinese Center for
   Disease Control & Prevention; National Institute for Nutrition & Health,
   Chinese Center for Disease Control & Prevention
RP Fang, HY (corresponding author), Natl Inst Nutr & Hlth, Chinese Ctr Dis Control & Prevent, Beijing 100050, Peoples R China.; Fang, HY (corresponding author), Natl Inst Nutr & Hlth, Chinese Ctr Dis Control & Prevent, NHC Key Lab Trace Element Nutr, Beijing 100050, Peoples R China.
EM fanghy@ninh.chinacdc.cn
RI Gong, Weiyi/KMX-3943-2024
FU National Health Commission of the People's Republic of China Medical
   Reform Major Program: China National Chronic Diseases and Nutrition
   Surveillance of Adults (2015-2017)
FX This study was supported by the National Health Commission of the
   People's Republic of China Medical Reform Major Program: China National
   Chronic Diseases and Nutrition Surveillance of Adults (2015-2017).
CR Akinbinu T.R., 2014, ACAD J, V5, P20, DOI [DOI 10.5897/MPR.2014.0121, 10.5897/MPR.2014.0121]
   Neves MEA, 2021, EUR J CLIN NUTR, V75, P1440, DOI 10.1038/s41430-020-00850-w
   [Anonymous], 2019, Chin J Cardiovasc Med, V24, P1
   [Anonymous], 2018, SOCIAL MEDIA TECHNOL
   Barnett TA, 2018, CIRCULATION, V138, pE142, DOI 10.1161/CIR.0000000000000591
   Beunza JJ, 2007, AM J HYPERTENS, V20, P1156, DOI 10.1016/j.amjhyper.2007.06.007
   Carson V, 2016, APPL PHYSIOL NUTR ME, V41, pS240, DOI 10.1139/apnm-2015-0630
   Cheng Xue, 2022, Wei Sheng Yan Jiu, V51, P347, DOI 10.19813/j.cnki.weishengyanjiu.2022.03.001
   Chung WC, 2010, KOREAN J FAM MED, V31, P547, DOI 10.4082/kjfm.2010.31.7.547
   Cook S, 2003, ARCH PEDIAT ADOL MED, V157, P821, DOI 10.1001/archpedi.157.8.821
   de Oliveira ID, 2023, J PEDIAT-BRAZIL, V99, P45, DOI 10.1016/j.jped.2022.02.007
   de Oliveira RG, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0168503
   Dubose KD, 2006, ACTA PAEDIATR, V95, P1005, DOI 10.1080/08035250600570553
   Gopinath B, 2012, J HUM HYPERTENS, V26, P350, DOI 10.1038/jhh.2011.40
   Gopinath B, 2014, MED SCI SPORT EXER, V46, P724, DOI 10.1249/MSS.0000000000000166
   Greer AE, 2015, J PHYS ACT HEALTH, V12, P68, DOI 10.1123/jpah.2013-0186
   Hardy LL, 2010, ARCH PEDIAT ADOL MED, V164, P643, DOI 10.1001/archpediatrics.2010.88
   High waist, 2018, WS/T611-2018
   Katzmarzyk PT, 2009, MED SCI SPORT EXER, V41, P998, DOI 10.1249/MSS.0b013e3181930355
   Khan MAB, 2019, DIABETES METAB SYND, V13, P2565, DOI 10.1016/j.dsx.2019.07.006
   Lissak G, 2018, ENVIRON RES, V164, P149, DOI 10.1016/j.envres.2018.01.015
   Liu LS, 2019, J GERIATR CARDIOL, V16, P182, DOI 10.11909/j.issn.1671-5411.2019.03.014
   Maras D, 2015, PREV MED, V73, P133, DOI 10.1016/j.ypmed.2015.01.029
   Mark AE, 2008, J PUBLIC HEALTH-UK, V30, P153, DOI 10.1093/pubmed/fdn022
   McGuire KA, 2012, OBESITY, V20, P576, DOI 10.1038/oby.2011.278
   Nightingale CM, 2017, ARCH DIS CHILD, V102, P612, DOI 10.1136/archdischild-2016-312016
   Noubiap JJ, 2022, LANCET CHILD ADOLESC, V6, P158, DOI 10.1016/S2352-4642(21)00374-6
   Park HS, 2004, INT J EPIDEMIOL, V33, P328, DOI 10.1093/ije/dyh032
   Park JH, 2020, KOREAN J FAM MED, V41, P365, DOI 10.4082/kjfm.20.0165
   Patterson R, 2018, EUR J EPIDEMIOL, V33, P811, DOI 10.1007/s10654-018-0380-1
   Pérez-Farinós N, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-016-3962-4
   Prevention TNBO, 2021, Report on Chinese Residents' Chronic Diseases and Nutrition 2020
   Schaan CW, 2019, INT J BEHAV NUTR PHY, V16, DOI 10.1186/s12966-019-0880-8
   Son Hyun Jin, 2008, J Prev Med Public Health, V41, P427, DOI 10.3961/jpmph.2008.41.6.427
   Tremblay MS, 2011, APPL PHYSIOL NUTR ME, V36, P59, DOI 10.1139/H11-012
   van der Berg JD, 2016, DIABETOLOGIA, V59, P709, DOI 10.1007/s00125-015-3861-8
   van Sluijs EMF, 2021, LANCET, V398, P429, DOI 10.1016/S0140-6736(21)01259-9
   Wang J, 2016, PUBLIC HEALTH NUTR, V19, P1147, DOI 10.1017/S1368980015002542
   Whitaker KM, 2017, MED SCI SPORT EXER, V49, P450, DOI 10.1249/MSS.0000000000001112
   WHO, 2018, GLOBAL STATUS REPORT
   Wittcopp C, 2016, PEDIATR REV, V37, P193, DOI [10.1542/pir.2014-0095, 10.1159/000449268]
   Woods HC, 2016, J ADOLESCENCE, V51, P41, DOI 10.1016/j.adolescence.2016.05.008
   Yang L, 2019, JAMA-J AM MED ASSOC, V321, P1587, DOI 10.1001/jama.2019.3636
   Yin N, 2022, NUTRIENTS, V14, DOI 10.3390/nu14091869
   You MA, 2012, ASIA-PAC J PUBLIC HE, V24, P464, DOI 10.1177/1010539511406105
   Yu DM, 2021, Food Nutr China, V27, P5, DOI [10.3969/j.issn.1006-9577.2021.04.002, DOI 10.3969/J.ISSN.1006-9577.2021.04.002]
   Zhang J., 2019, Chin J Sch Health, V40, P1780
NR 47
TC 3
Z9 3
U1 10
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD JUN 27
PY 2024
VL 24
IS 1
AR 1715
DI 10.1186/s12889-024-19227-w
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA WX2E4
UT WOS:001258095100001
PM 38937700
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Homberg, JR
   la Fleur, SE
   Cuppen, E
AF Homberg, Judith R.
   la Fleur, Susanne E.
   Cuppen, Edwin
TI Serotonin Transporter Deficiency Increases Abdominal Fat in Female, but
   Not Male Rats
SO OBESITY
LA English
DT Article
ID KNOCK-OUT MICE; METABOLIC SYNDROME; 5-HT1A RECEPTOR; BRAIN; OBESITY;
   REGION; POLYMORPHISM; EXPRESSION; DEPRESSION; GENDER
AB Depression and abdominal obesity often co-occur, predominantly in women, and are associated with an increased risk for the development of glucose intolerance and subsequently type 2 diabetes. The underlying mechanisms are poorly understood. We found that female, but not male, depression-prone serotonin transporter knockout (SERT-/-) rats had a strong increase (54%) in abdominal fat, whereas no increases in plasma concentrations of glucose and insulin were observed. Surprisingly, application of a high-fat, high-sucrose (HFHS)-choice diet, which results in increased abdominal fat deposition and increased plasma glucose levels in wild-type rats, did not result in elevated plasma glucose levels in female SERT-/- rats. Our results show that serotonin transporter deficiency affects abdominal fat deposition in a sex-dependent way, but protects against rises in glucose levels, and thereby potentially glucose intolerance. The increased abdominal fat formation could result from serotonin-mediated developmental changes and provides heuristic value for understanding the effects of the depression-associated serotonin transporter promoter polymorphism in humans.
C1 [Homberg, Judith R.; Cuppen, Edwin] Univ Med Ctr Utrecht, Hubrecht Inst, Utrecht, Netherlands.
   [Homberg, Judith R.] Radboud Univ Nijmegen, Med Ctr, Dept Cognit Neurosci 126, Ctr Neurosci,Donders Inst Brain Cognit & Behav, NL-6525 ED Nijmegen, Netherlands.
   [la Fleur, Susanne E.] Univ Med Ctr Utrecht, Dept Neurosci & Pharmacol, Rudolf Magnus Inst Neurosci, Utrecht, Netherlands.
   [la Fleur, Susanne E.] Univ Amsterdam, Acad Med Ctr, Dept Endocrinol & Metab, NL-1105 AZ Amsterdam, Netherlands.
C3 Royal Netherlands Academy of Arts & Sciences; Hubrecht Institute (KNAW);
   Utrecht University; Utrecht University Medical Center; Radboud
   University Nijmegen; Utrecht University; Utrecht University Medical
   Center; University of Amsterdam; Academic Medical Center Amsterdam
RP Cuppen, E (corresponding author), Univ Med Ctr Utrecht, Hubrecht Inst, Utrecht, Netherlands.
EM e.cuppen@niob.knaw.nl
RI Homberg, J.R./N-4172-2019; Cuppen, Edwin/H-2389-2016
OI Homberg, Judith/0000-0002-7621-1010; Cuppen, Edwin/0000-0002-0400-9542
FU Netherlands Organisation for Scientific Research (NWO) [91676160];
   European Heads of Research Councils; European Science Foundation EURYI
   (European Young Investigator)
FX We like to acknowledge Mieneke Luijendijk for technical assistance and
   Mark Verheul for genotyping of animals. This work is funded by The
   Netherlands Organisation for Scientific Research (NWO), grant #91676160,
   awarded to J.R.H. and the award "Exploiting natural and induced genetic
   variation in the laboratory rat" to E. C. from the European Heads of
   Research Councils and European Science Foundation EURYI (European Young
   Investigator) Awards scheme. NWO, the European Heads of Research
   Councils, and the European Science Foundation had no further role in
   study design; in the collection, analysis, and interpretation of data;
   in the writing of the report; and in the decision to submit the paper
   for publication.
CR Brown GW, 2008, J AFFECT DISORDERS, V111, P1, DOI 10.1016/j.jad.2008.04.009
   Canli T, 2007, NAT NEUROSCI, V10, P1103, DOI 10.1038/nn1964
   Dallman MF, 2007, CURR ALZHEIMER RES, V4, P199, DOI 10.2174/156720507780362236
   Guimarães Camila, 2006, Arq Bras Endocrinol Metab, V50, P1020, DOI 10.1590/S0004-27302006000600007
   Halford JCG, 2007, DRUGS, V67, P27, DOI 10.2165/00003495-200767010-00004
   Hinney A. et al., 1997, Life Sciences, V61, pPL295, DOI 10.1016/S0024-3205(97)00888-6
   Homberg JR, 2007, NEUROSCIENCE, V146, P1662, DOI 10.1016/j.neuroscience.2007.03.030
   Homberg JR, 2008, NEUROPHARMACOLOGY, V55, P80, DOI 10.1016/j.neuropharm.2008.04.016
   Jiang X, 2009, PSYCHONEUROENDOCRINO, V34, P317, DOI 10.1016/j.psyneuen.2008.09.011
   Kahl KG, 2005, PSYCHOSOM MED, V67, P407, DOI 10.1097/01.psy.0000160458.95955.f4
   la Fleur SE, 2007, INT J OBESITY, V31, P1286, DOI 10.1038/sj.ijo.0803570
   Leibowitz SF, 1998, BIOL PSYCHIAT, V44, P851, DOI 10.1016/S0006-3223(98)00186-3
   Li Q, 2003, J NEUROCHEM, V84, P1256, DOI 10.1046/j.1471-4159.2003.01607.x
   Li Q, 2000, J NEUROSCI, V20, P7888
   Monteleone P, 2006, PSYCHOSOM MED, V68, P99, DOI 10.1097/01.psy.0000195746.52074.63
   Muraki Y, 2004, J NEUROSCI, V24, P7159, DOI 10.1523/JNEUROSCI.1027-04.2004
   Murphy DL, 2008, NAT REV NEUROSCI, V9, P85, DOI 10.1038/nrn2284
   Nonogaki K, 2007, INT J NEUROPSYCHOPH, V10, P675, DOI 10.1017/S1461145706007206
   Olivier JDA, 2008, NEUROSCIENCE, V152, P573, DOI 10.1016/j.neuroscience.2007.12.032
   Olivier JDA, 2008, EUR J PHARMACOL, V590, P190, DOI 10.1016/j.ejphar.2008.06.008
   Pallottini V., 2008, Infectious Disorders - Drug Targets, V8, P52
   Parsey RV, 2006, AM J PSYCHIAT, V163, P48, DOI 10.1176/appi.ajp.163.1.48
   Qu Y, 2005, PSYCHOPHARMACOLOGY, V180, P12, DOI 10.1007/s00213-005-2231-5
   Regitz-Zagrosek V, 2006, CLIN RES CARDIOL, V95, P136, DOI 10.1007/s00392-006-0351-5
   Ren-Patterson RF, 2006, CELL MOL NEUROBIOL, V26, P755, DOI 10.1007/s10571-006-9048-6
   Shanahan NA, 2009, BIOL PSYCHIAT, V65, P401, DOI 10.1016/j.biopsych.2008.09.026
   Smits BMG, 2006, PHARMACOGENET GENOM, V16, P159
   Somerville EM, 2007, EUR J NEUROSCI, V25, P3115, DOI 10.1111/j.1460-9568.2007.05567.x
   Sookoian S, 2008, OBESITY, V16, P488, DOI 10.1038/oby.2007.64
   Tecott LH, 2007, CELL METAB, V6, P352, DOI 10.1016/j.cmet.2007.09.012
   Weber-Hamann B, 2002, PSYCHOSOM MED, V64, P274, DOI 10.1097/00006842-200203000-00010
   Wellman CL, 2007, J NEUROSCI, V27, P684, DOI 10.1523/JNEUROSCI.4595-06.2007
NR 32
TC 26
Z9 28
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD JAN
PY 2010
VL 18
IS 1
BP 137
EP 145
DI 10.1038/oby.2009.139
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 538UU
UT WOS:000273210400020
PM 19444235
OA Bronze
DA 2025-06-11
ER

PT J
AU Bourebaba, L
   Michalak, I
   Röcken, M
   Marycz, K
AF Bourebaba, Lynda
   Michalak, Izabela
   Roecken, Michael
   Marycz, Krzysztof
TI Cladophora glomerata methanolic extract decreases oxidative
   stress and improves viability and mitochondrial potential in equine
   adipose derived mesenchymal stem cells (ASCs)
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Cladophora glomerata; EMS; ASCs; Oxidative stress; Mitopotential;
   Inflammation
ID ENDOPLASMIC-RETICULUM STRESS; HYDROGEN-PEROXIDE; ANTIOXIDANT ENZYMES;
   FREE-RADICALS; AMINO-ACIDS; FATTY-ACIDS; APOPTOSIS; DAMAGE; DYSFUNCTION;
   MACROALGAE
AB Reactive oxygen species (ROS) are key mediators of several cellular damage and thus associated with equine diseases such as inflammation and metabolic syndrome. This study aimed to evaluate the protective and antioxidant activities of methanolic extract prepared from Cladophora glomerata (C. glomerata) biomass, on equine adipose derived mesenchymal stem cells (EqASCs), under experimental oxidative stress induced by H2O2. Pretreatment of EqASCs cells with different concentrations of C. glomerata methanolic extract (1% and 5%) provided a clear protection against cellular damage triggered by H2O2. The cell's apoptotic status was significantly regulated, with promotion of cell viability, down-regulation of pro-apoptotic (p21, p53, Bax and Casp-9) genes expression, concomitant to up-regulation of the survival gene Bcl-2, this being supported by a mitigation of the endoplasmic reticulum (ER) stress and significant minimization of mitochondrial dysfunction. The results also showed that C. glomerata extract significantly increased the antioxidant enzymes Superoxide dismutase (SOD) and Catalase (CAT) activities, positively regulated the enzymes genes expression, and markedly reduced the protein carbonyls derivatives production. Finally, RT-qPCR analysis of the inflammatory related genes allowed to highlight a promising anti-inflammatory and immunomodulatory effect of this extract. Due to the valuable antioxidant and anti-inflammatory activities, C. glomerata may have potential benefits for the prevention of equine diseases associated with oxidative stress, including metabolic syndrome.
C1 [Bourebaba, Lynda; Marycz, Krzysztof] Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, Norwida 27B, PL-50375 Wroclaw, Poland.
   [Michalak, Izabela] Wroclaw Univ Sci & Technol, Fac Chem, Dept Adv Mat Technol, Smoluchowskiego 25, PL-50372 Wroclaw, Poland.
   [Roecken, Michael; Marycz, Krzysztof] Justus Liebig Univ, Equine Clin Equine Surg, Fac Vet Med, D-35392 Giessen, Germany.
C3 Wroclaw University of Environmental & Life Sciences; Wroclaw University
   of Science & Technology; Justus Liebig University Giessen
RP Marycz, K (corresponding author), Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, Norwida 27B, PL-50375 Wroclaw, Poland.
EM krzysztof.marycz@upwr.edu.pl
RI Bourebaba, Lynda/AAX-7613-2020; Michalak, Izabela/P-3770-2015
OI Michalak, Izabela/0000-0001-8084-9642; Lynda,
   Bourebaba/0000-0003-0660-8706
FU grant entitled "The effect of bioactive algae enriched by biosorption on
   the certain minerals such as Cr(III), Mg(II) and Mn(II) on the status of
   glucose in the course of metabolic syndrome horses. Evaluation in vitro
   and in vivo" by The National Science C [2015/18/E/NZ9/00607]
FX This manuscript is financed in the framework of grant entitled "The
   effect of bioactive algae enriched by biosorption on the certain
   minerals such as Cr(III), Mg(II) and Mn(II) on the status of glucose in
   the course of metabolic syndrome horses. Evaluation in vitro and in
   vivo" (2015/18/E/NZ9/00607) attributed by The National Science Centre in
   Poland.
CR Abd Hamid NA, 2011, NUTR J, V10, DOI 10.1186/1475-2891-10-37
   Abraham S, 2005, INDIAN J MED RES, V121, P111
   [Anonymous], 2012, P PAK ACAD SCI
   Anraku M, 2015, LIFE SCI, V134, P36, DOI 10.1016/j.lfs.2015.05.010
   Aragno M, 1997, J ENDOCRINOL, V155, P233, DOI 10.1677/joe.0.1550233
   Arulselvan P, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/5276130
   Basinska K, 2015, J VET SCI, V16, P113, DOI [10.4142/jvs.2015.16.1.113, 10.4142/jvs.2015.16.1.107]
   Cao SS, 2014, ANTIOXID REDOX SIGN, V21, P396, DOI 10.1089/ars.2014.5851
   Carballeira NM, 1997, LIPIDS, V32, P1271, DOI 10.1007/s11745-006-0163-4
   Cavallo RA, 2013, CENT EUR J BIOL, V8, P646, DOI 10.2478/s11535-013-0181-6
   Clementi ME, 2018, NUTR NEUROSCI, V21, P447, DOI 10.1080/1028415X.2017.1306935
   Costa WMV, 2002, FREE RADICAL BIO MED, V33, P1507, DOI 10.1016/S0891-5849(02)01086-9
   Doulias PT, 2005, FREE RADICAL RES, V39, P125, DOI 10.1080/10715760400017244
   Dröge W, 2002, PHYSIOL REV, V82, P47, DOI 10.1152/physrev.00018.2001
   El Gamal Ali A, 2010, Saudi Pharm J, V18, P1, DOI 10.1016/j.jsps.2009.12.001
   Fabrowska J, 2015, CHEMIK, V69, P495
   Frank N, 2010, J VET INTERN MED, V24, P467, DOI 10.1111/j.1939-1676.2010.0503.x
   Fukamachi Y, 1998, BIOCHEM BIOPH RES CO, V246, P364, DOI 10.1006/bbrc.1998.8621
   Gu SY, 2016, CHEM-BIOL INTERACT, V245, P100, DOI 10.1016/j.cbi.2016.01.005
   Guerriero E, 2017, INT J ONCOL, V50, P468, DOI 10.3892/ijo.2017.3835
   Guo CY, 2013, NEURAL REGEN RES, V8, P2003, DOI 10.3969/j.issn.1673-5374.2013.21.009
   Hajimahmoodi M, 2010, J APPL PHYCOL, V22, P43, DOI 10.1007/s10811-009-9424-y
   Horincar VB, 2014, J APPL PHYCOL, V26, P551, DOI 10.1007/s10811-013-0053-0
   Hudson JB, 1998, J APPL PHYCOL, V10, P427, DOI 10.1023/A:1008004117305
   Hwang KA, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1172-3
   Kathirvel A, 2016, ARAB J CHEM, V9, pS1435, DOI 10.1016/j.arabjc.2012.03.018
   Khuantrairong T, 2011, INT J AGRIC BIOL, V13, P297
   Kirschvink N, 2008, VET J, V177, P178, DOI 10.1016/j.tvjl.2007.07.033
   Li JM, 2003, WORLD J GASTROENTERO, V9, P562, DOI 10.3748/wjg.v9.i3.562
   Li LC, 2017, MOL MED REP, V16, P3673, DOI 10.3892/mmr.2017.6957
   Liu RH, 2003, AM J CLIN NUTR, V78, p517S, DOI 10.1093/ajcn/78.3.517S
   Malhotra JD, 2008, P NATL ACAD SCI USA, V105, P18525, DOI 10.1073/pnas.0809677105
   Manferdini C, 2017, OSTEOARTHR CARTILAGE, V25, P1161, DOI 10.1016/j.joca.2017.01.011
   Marycz K, 2017, MAR DRUGS, V15, DOI 10.3390/md15120385
   Messyasz B, 2015, OPEN CHEM, V13, P1108, DOI 10.1515/chem-2015-0124
   Michalak I, 2015, ENG LIFE SCI, V15, P160, DOI 10.1002/elsc.201400191
   Morabito F, 2004, MEDIAT INFLAMM, V13, P381, DOI 10.1080/09629350400008760
   Morgan R, 2015, VET REC, V177, P173, DOI 10.1136/vr.103226
   Müller L, 2010, LWT-FOOD SCI TECHNOL, V43, P992, DOI 10.1016/j.lwt.2010.02.004
   Othman SB., 2015, Reviews in Agricultural Sci, V3, P40, DOI DOI 10.7831/RAS.3.40
   Ozkan A, 2007, BIOLOGIA, V62, P360, DOI 10.2478/s11756-007-0060-1
   Panche AN, 2016, J NUTR SCI, V5, DOI 10.1017/jns.2016.41
   Pikosz M, 2016, OCEANOL HYDROBIOL ST, V45, P202, DOI 10.1515/ohs-2016-0019
   Ravipati AS, 2012, BMC COMPLEM ALTERN M, V12, DOI 10.1186/1472-6882-12-173
   REDDY ACP, 1994, J NUTR BIOCHEM, V5, P181
   Redza-Dutordoir M, 2016, BBA-MOL CELL RES, V1863, P2977, DOI 10.1016/j.bbamcr.2016.09.012
   Rho S, 2005, BIOL PHARM BULL, V28, P661, DOI 10.1248/bpb.28.661
   Sharma S, 2015, J EVID-BASED INTEGR, V20, P203, DOI 10.1177/2156587215573664
   Sies H, 2014, J BIOL CHEM, V289, P8735, DOI 10.1074/jbc.R113.544635
   Singleton V., 1965, Methods Enzymol, V16, P144, DOI 10.5344/ajev.1965.16.3.144
   Srimaroeng C, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/320167
   Tian B, 2009, LETT APPL MICROBIOL, V49, P689, DOI 10.1111/j.1472-765X.2009.02727.x
   Tse G, 2016, FRONT PHYSIOL, V7, DOI 10.3389/fphys.2016.00313
   Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
   Walker J M, 1994, Methods Mol Biol, V32, P5
   Watson SB, 2003, PHYCOLOGIA, V42, P319, DOI 10.2216/i0031-8884-42-4-319.1
   Wei H, 2010, J CELL BIOCHEM, V111, P967, DOI 10.1002/jcb.22785
   Williams AB, 2016, CSH PERSPECT MED, V6, DOI 10.1101/cshperspect.a026070
   Wu HC, 2003, FOOD RES INT, V36, P949, DOI 10.1016/S0963-9969(03)00104-2
NR 59
TC 28
Z9 29
U1 0
U2 6
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD MAR
PY 2019
VL 111
BP 6
EP 18
DI 10.1016/j.biopha.2018.12.020
PG 13
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA HL5AK
UT WOS:000458737800002
PM 30553132
OA gold
DA 2025-06-11
ER

PT J
AU Karasek, R
   Collins, S
   Clays, E
   Bortkiewicz, A
   Ferrario, M
AF Karasek, Robert
   Collins, Sean
   Clays, Els
   Bortkiewicz, Alicja
   Ferrario, Marco
TI DESCRIPTION OF A LARGE-SCALE STUDY DESIGN TO ASSESS WORK-STRESS-DISEASE
   ASSOCIATIONS FOR CARDIOVASCULAR DISEASE
SO INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH
LA English
DT Review
DE Stress; Cardiovascular disease; Low control; Growth and regeneration;
   Large-scale study design
ID HEART-RATE-VARIABILITY; AMBULATORY BLOOD-PRESSURE; RISK-FACTORS; JOB
   STRAIN; CORONARY RISK; TRENDS
AB We claim that a new level of studies is needed to answer a series of important questions about the expanding global chronic disease burden for cardiovascular disease (CVD) and for related conditions such as diabetes, metabolic syndrome, and obesity. These require a new study design structure, related to a new level of theory that goes beyond the current single-factor, a-theoretic epidemiological studies. This new platform for the design of large-scale Work/Stress/Disease studies would assess CVD-related disease mechanisms in a more general and dynamic form, based on the use of new tools for measuring autonomic functions in an occupational stress context and a new theory of disease causation. A sample outline is presented for such a study, based on Stress-Disequilibrium Theory (SDT) hypotheses, building on analytic tools developed for the assessment of stress-related exhaustion effects and chronic disease risks from Heart Rate Variability (HRV) research studies. The goal is to assess the associations between social organizational risks, particularly at work, and hypertension, metabolic syndrome, and diabetes II. The study design is multi-stage, spanning across several levels of disease-related de-regulation, and addressing co-morbidity of the conditions themselves. The study design is meant to span across a broad social population at all levels and would probably be multi-site, involving several countries, to yield the larger sample increased power for finding associations for work-physiological effects.
C1 [Karasek, Robert] Univ Massachusetts Lowell, Dept Work Environm, Lowell, MA 01854 USA.
   [Karasek, Robert] Univ Copenhagen, Dept Psychol, Copenhagen, Denmark.
   [Collins, Sean] Univ Massachusetts Lowell, Dept Phys Therapy, Lowell, MA USA.
   [Clays, Els] Univ Hosp, Dept Publ Hlth, Ghent, Belgium.
   [Bortkiewicz, Alicja] Nofer Inst Occupat Med, Dept Work Physiol & Ergon, Lodz, Poland.
   [Ferrario, Marco] Univ Insubria, Dept Expt & Clin Biomed Sci, Insubria, Varese, Italy.
C3 University of Massachusetts System; University of Massachusetts Lowell;
   University of Copenhagen; University of Massachusetts System; University
   of Massachusetts Lowell; Ghent University; Ghent University Hospital;
   Nofer Institute of Occupational Medicine; University of Insubria
RP Karasek, R (corresponding author), Univ Massachusetts Lowell, Dept Work Environm, Kitson Hall,1 Univ Ave, Lowell, MA 01854 USA.
EM Robert_Karasek@uml.edu
RI Ferrario, Marco/ABH-2115-2021; Bortkiewicz, Alicja/G-5513-2010
OI Ferrario, Marco M/0000-0003-2741-7124; Collins,
   Sean/0000-0002-7609-6219; Clays, Els/0000-0002-1092-945X; Bortkiewicz,
   Alicja/0000-0002-0042-4597
FU European Union [WND-POKL.02.03.01-00-001/08]
FX Alicja Bortkiewicz took part in this work within the confines of the
   project entitled: "Development of comprehensive projects for prevention
   of cardiovascular diseases" co-financed by the European Union under the
   European Social Fund: Human Capital Programme (project no.
   WND-POKL.02.03.01-00-001/08).
CR Antikainen RL, 2006, EUR J CARDIOV PREV R, V13, P13, DOI 10.1097/00149831-200602000-00004
   ASHBY RW, 1956, INTRO CYBERNETICS, P202
   Belkic KL, 2004, SCAND J WORK ENV HEA, V30, P85, DOI 10.5271/sjweh.769
   Bongers PM, 2002, AM J IND MED, V41, P315, DOI 10.1002/ajim.10050
   Bortkiewicz A, 1996, J AUTONOM NERV SYST, V59, P91, DOI 10.1016/0165-1838(96)00009-4
   Bortkiewicz A, 1995, ELECTRO MAGNETOBIOL, V14, P177, DOI 10.3109/15368379509030728
   Bortkiewicz Alicja, 2006, International Journal of Occupational Medicine and Environmental Health, V19, P53, DOI 10.2478/v10001-006-0001-1
   BRENNINKMEIJER V, 2003, REV INVENTORY NATL S
   Camm AJ, 1996, CIRCULATION, V93, P1043
   Carnethon M, 2009, CIRCULATION, V120, P1725, DOI 10.1161/CIRCULATIONAHA.109.192653
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Chandola T, 2008, EUR HEART J, V29, P640, DOI 10.1093/eurheartj/ehm584
   Chandola T, 2010, NEUROSCI BIOBEHAV R, V35, P51, DOI 10.1016/j.neubiorev.2009.11.005
   Clays E, 2011, INT ARCH OCC ENV HEA, V84, P185, DOI 10.1007/s00420-010-0537-z
   Collins S, 2010, INT J OCCUP MED ENV, V23, P267, DOI 10.2478/v10001-010-0023-6
   Collins SM, 2005, AM J IND MED, V48, P182, DOI 10.1002/ajim.20204
   Dollard M.F., 2010, Contemporary occupational health psychology: Global perspectives on research and practice, V1, P208, DOI [10.1002/9780470661550.ch11, DOI 10.1002/9780470661550.CH11]
   Evans A, 2001, INT J EPIDEMIOL, V30, pS35, DOI 10.1093/ije/30.suppl_1.S35
   Hemingway H, 2005, CIRCULATION, V111, P3071, DOI 10.1161/CIRCULATIONAHA.104.497347
   Hintsanen M, 2007, INT J BEHAV MED, V14, P202, DOI 10.1007/BF03002994
   HOGELUND J, 2002, ACTIVE LABOR MARKET, P18
   Kageyama T, 1998, IND HEALTH, V36, P263, DOI 10.2486/indhealth.36.263
   Kang MG, 2004, YONSEI MED J, V45, P838, DOI 10.3349/ymj.2004.45.5.838
   KARASEK R, 1981, AM J PUBLIC HEALTH, V71, P694, DOI 10.2105/AJPH.71.7.694
   Karasek R, 1998, J Occup Health Psychol, V3, P322, DOI 10.1037/1076-8998.3.4.322
   KARASEK R, 1990, HLTH WORK STRESS PRO, P152
   Karasek R, 2004, B SCI TECHNOL SOC, V24, P471
   Karasek R.A., 2004, Bulletin of Science, Technology Society, V24, P397
   Karasek R, 2008, SCAND J WORK ENV HEA, P117
   Kristensen T S, 1996, J Occup Health Psychol, V1, P246, DOI 10.1037/1076-8998.1.3.246
   Kuulasmaa K, 2000, LANCET, V355, P675, DOI 10.1016/S0140-6736(99)11180-2
   LAMONTAGNE AD, BMC PUBLIC HLTH, V181
   Lehrer PM, 2003, PSYCHOSOM MED, V65, P796, DOI 10.1097/01.PSY.0000089200.81962.19
   Lloyd-Jones D, 2010, CIRCULATION, V121, pE46, DOI 10.1161/CIRCULATIONAHA.109.192667
   Loerbroks A, 2010, ALLERGY, V65, P1298, DOI 10.1111/j.1398-9995.2010.02375.x
   Loerbroks A, 2010, J PSYCHOSOM RES, V69, P151, DOI 10.1016/j.jpsychores.2010.03.004
   Marmot M, 2006, SOCIAL DETERMINANTS
   Marmot MG, 1997, LANCET, V350, P235, DOI 10.1016/S0140-6736(97)04244-X
   Martino TA, 2009, CIRC RES, V105, P1047, DOI 10.1161/CIRCRESAHA.109.206201
   *NSIB, 2003, FIN SEC CAS SICKN DI
   Prigogine I., 1984, Order out of chaos: The evolutionary paradigm and the physical sciences
   *PUBL BROADC SERV, CAUS DEPR MOV ONL FO
   Recordati G, 2003, AUTON NEUROSCI-BASIC, V103, P1, DOI 10.1016/S1566-0702(02)00260-6
   Recordati G, 2002, J THEOR BIOL, V214, P293, DOI 10.1006/jtbi.2001.2461
   Riese H, 2004, SCAND J WORK ENV HEA, V30, P477, DOI 10.5271/sjweh.837
   RIESE H, 2000, THESIS VRIJE U AMSTE
   *SOC SEC ADM, 2001, ANN STAT REP SOC SEC
   Stansfeld S, 2006, SCAND J WORK ENV HEA, V32, P443, DOI 10.5271/sjweh.1050
   Syme S Leonard, 2005, Epidemiol Perspect Innov, V2, P2, DOI 10.1186/1742-5573-2-2
   SYME SL, 2005, LANCET, V365, P1099
   Szmigielski S, 1998, Blood Press Monit, V3, P323
   Theorell T., 2006, Stress and cardiovascular disease
   Theorell T, 2009, RES OCCUP STRESS WEL, V7, P249, DOI 10.1108/S1479-3555(2009)0000007010
   van Amelsvoort LGPM, 2000, INT ARCH OCC ENV HEA, V73, P255, DOI 10.1007/s004200050425
   Van der Doef M, 1999, WORK STRESS, V13, P87, DOI 10.1080/026783799296084
   Vrijkotte TGM, 2000, HYPERTENSION, V35, P880, DOI 10.1161/01.HYP.35.4.880
NR 56
TC 16
Z9 27
U1 0
U2 12
PU NOFER INST OCCUPATIONAL MEDICINE, POLAND
PI LODZ
PA SW TERESY 8, LODZ, 91-348, POLAND
SN 1232-1087
EI 1896-494X
J9 INT J OCCUP MED ENV
JI Int. J. Occup. Med. Environ. Health
PY 2010
VL 23
IS 3
BP 293
EP 312
DI 10.2478/v10001-010-0035-2
PG 20
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 718QF
UT WOS:000287139600008
PM 21306975
DA 2025-06-11
ER

PT J
AU Mariana, M
   Cairrao, E
AF Mariana, Melissa
   Cairrao, Elisa
TI Phthalates Implications in the Cardiovascular System
SO JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
LA English
DT Review
DE plastic contaminants; phthalates; cardiovascular system; blood pressure;
   atherosclerosis; cardiometabolic risk
ID INCREASED BLOOD-PRESSURE; BISPHENOL-A; ENDOTHELIAL DYSFUNCTION;
   BETA-THUJAPLICIN; IN-VITRO; CAROTID ATHEROSCLEROSIS; CARDIAC
   DEVELOPMENT; CIRCULATING LEVELS; MATERNAL EXPOSURE; OXIDATIVE STRESS
AB Today's sedentary lifestyle and eating habits have been implicated as some of the causes of the increased incidence of several diseases, including cancer and cardiovascular diseases. However, environmental pollutants have also been identified as another possible cause for this increase in recent decades. The constant human exposure to plastics has been raising attention regarding human health, particularly when it comes to phthalates. These are plasticizers used in the manufacture of industrial and consumer products, such as PVC (Polyvinyl Chloride) plastics and personal care products, with endocrine-disrupting properties, as they can bind molecular targets in the body and interfere with hormonal function. Since these compounds are not covalently bound to the plastic, they are easily released into the environment during their manufacture, use, or disposal, leading to increased human exposure and enhancing health risks. In fact, some studies have related phthalate exposure with cardiovascular health, having already shown a positive association with the development of hypertension and atherosclerosis in adults and some cardiometabolic risk factors in children and adolescents. Therefore, the main purpose of this review is to present and relate the most recent studies concerning the implications of phthalates effects on the cardiovascular system.
C1 [Mariana, Melissa; Cairrao, Elisa] Univ Beira Interior, Hlth Sci Res Ctr, CICS UBI, P-6200506 Covilha, Portugal.
   [Cairrao, Elisa] Univ Beira Interior, Fac Hlth Sci, FCS UBI, P-6200506 Covilha, Portugal.
C3 Universidade da Beira Interior; Universidade da Beira Interior
RP Cairrao, E (corresponding author), Univ Beira Interior, Hlth Sci Res Ctr, CICS UBI, P-6200506 Covilha, Portugal.; Cairrao, E (corresponding author), Univ Beira Interior, Fac Hlth Sci, FCS UBI, P-6200506 Covilha, Portugal.
EM melissa.r.mariana@gmail.com; ecairrao@fcsaude.ubi.pt
RI ; Cairrao, Elisa/AAB-1164-2020
OI Mariana, Melissa/0000-0003-1875-0144; Cairrao, Elisa/0000-0002-4823-5701
FU FEDER funds through the POCI -COMPETE 2020 -Operational Programme
   Competitiveness and Internationalisation in Axis I -Strengthening
   research, technological development and innovation
   [POCI-01-0145-FEDER007491]; FCT -Foundation for Science and Technology
   [UID/Multi/00709/2019]
FX This work was supported by FEDER funds through the POCI -COMPETE 2020
   -Operational Programme Competitiveness and Internationalisation in Axis
   I -Strengthening research, technological development and innovation
   (Project POCI-01-0145-FEDER007491) and National Funds by FCT -Foundation
   for Science and Technology (Project UID/Multi/00709/2019).
CR Al-Qaraghouli M, 2017, FRONT PEDIATR, V5, DOI 10.3389/fped.2017.00144
   Amara I, 2019, ENVIRON SCI POLLUT R, V26, P7540, DOI 10.1007/s11356-019-04219-w
   Amin MM, 2018, CHEMOSPHERE, V211, P547, DOI 10.1016/j.chemosphere.2018.07.172
   Arguelles DBM, 2013, TOXICOL APPL PHARM, V266, P95, DOI 10.1016/j.taap.2012.10.027
   Arima Y, 2003, J ANTIMICROB CHEMOTH, V51, P113, DOI 10.1093/jac/dkg037
   ARONSON CE, 1978, TOXICOL APPL PHARM, V44, P155, DOI 10.1016/0041-008X(78)90295-8
   Ban JB, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0097607
   Burton GJ, 2009, PLACENTA, V30, pS43, DOI 10.1016/j.placenta.2008.11.003
   Cai JZ, 2019, ENVIRON POLLUT, V255, DOI 10.1016/j.envpol.2019.113155
   Cantonwine DE, 2016, ENVIRON HEALTH PERSP, V124, P1651, DOI 10.1289/EHP188
   Deng T, 2019, TOXICOL LETT, V309, P42, DOI 10.1016/j.toxlet.2019.03.011
   Deng T, 2019, ENVIRON POLLUT, V247, P927, DOI 10.1016/j.envpol.2019.01.099
   Dong RH, 2018, ENVIRON INT, V121, P340, DOI 10.1016/j.envint.2018.09.028
   Falkner B, 2015, HYPERTENSION, V65, P926, DOI 10.1161/HYPERTENSIONAHA.114.03586
   Ferguson KK, 2015, PLACENTA, V36, P699, DOI 10.1016/j.placenta.2015.04.002
   Frederiksen H, 2007, MOL NUTR FOOD RES, V51, P899, DOI 10.1002/mnfr.200600243
   Gillum N, 2009, TOXICOL APPL PHARM, V236, P25, DOI 10.1016/j.taap.2008.12.027
   Golestanzadeh M, 2019, ENVIRON SCI POLLUT R, V26, P35670, DOI 10.1007/s11356-019-06589-7
   Gore AC, 2015, ENDOCR REV, V36, pE1, DOI 10.1210/er.2015-1010
   Han XY, 2020, ECOTOX ENVIRON SAFE, V189, DOI 10.1016/j.ecoenv.2019.109944
   Harmon AC, 2016, CLIN SCI, V130, P409, DOI 10.1042/CS20150702
   Heacock M, 2016, ENVIRON HEALTH PERSP, V124, P550, DOI 10.1289/ehp.1509699
   Hill AJ, 2005, TOXICOL SCI, V86, P6, DOI 10.1093/toxsci/kfi110
   Jaimes R, 2019, CIRC-ARRHYTHMIA ELEC, V12, DOI 10.1161/CIRCEP.119.007294
   Jaimes R, 2017, AM J PHYSIOL-HEART C, V313, pH1044, DOI 10.1152/ajpheart.00364.2017
   James-Todd T, 2012, ENVIRON HEALTH PERSP, V120, P1307, DOI 10.1289/ehp.1104717
   James-Todd TM, 2016, ENVIRON HEALTH-GLOB, V15, DOI 10.1186/s12940-016-0136-x
   Jang YS, 2005, J AGR FOOD CHEM, V53, P1934, DOI 10.1021/jf048472a
   Jenkins R, 2019, PEDIATR NEPHROL, V34, P1413, DOI 10.1007/s00467-019-04244-4
   Kataria A, 2017, PEDIATR RES, V81, P857, DOI 10.1038/pr.2017.16
   Katsikantami I, 2016, ENVIRON INT, V97, P212, DOI 10.1016/j.envint.2016.09.013
   Kim JH, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071392
   Koch HM, 2006, INT J ANDROL, V29, P155, DOI 10.1111/j.1365-2605.2005.00607.x
   Krenn BM, 2009, J VIROL, V83, P58, DOI 10.1128/JVI.01543-08
   Lalan S, 2018, J PEDIATR-US, V202, P163, DOI 10.1016/j.jpeds.2018.06.007
   Lee KI, 2016, ARCH TOXICOL, V90, P1211, DOI 10.1007/s00204-015-1539-0
   Lind PM, 2012, DIABETES CARE, V35, P1519, DOI 10.2337/dc11-2396
   Lind PM, 2011, ATHEROSCLEROSIS, V218, P207, DOI 10.1016/j.atherosclerosis.2011.05.001
   Liu NR, 2017, TOXICOL IN VITRO, V44, P49, DOI 10.1016/j.tiv.2017.06.024
   Liu SC, 2009, CANCER LETT, V286, P240, DOI 10.1016/j.canlet.2009.05.038
   Lu XL, 2018, ENVIRON SCI POLLUT R, V25, P20550, DOI 10.1007/s11356-018-2367-6
   Lurbe E, 2009, J HYPERTENS, V27, P1719, DOI 10.1097/HJH.0b013e32832f4f6b
   Mansouri V, 2019, ENVIRON SCI POLLUT R, V26, P18604, DOI 10.1007/s11356-019-05123-z
   Mariana M, 2018, CARDIOVASC TOXICOL, V18, P356, DOI 10.1007/s12012-017-9439-6
   Mariana M, 2016, ENVIRON INT, V94, P758, DOI 10.1016/j.envint.2016.07.004
   Milosevic N, 2018, ENVIRON MONIT ASSESS, V190, DOI 10.1007/s10661-017-6398-0
   Pappano A. J., 2013, CARDIOVASCULAR PHYSL, P171, DOI DOI 10.1016/B978-0-323-08697-4.00009-5
   Park J, 2019, ENVIRON RES, V172, P10, DOI 10.1016/j.envres.2019.02.001
   Peres GM, 2018, J CARDIOVASC DEV DIS, V5, DOI 10.3390/jcdd5010003
   Philips EM, 2019, HUM REPROD, V34, P365, DOI 10.1093/humrep/dey364
   Philips EM, 2017, REPROD TOXICOL, V68, P105, DOI 10.1016/j.reprotox.2016.08.015
   Posnack NG, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0121927
   Posnack NG, 2014, CARDIOVASC TOXICOL, V14, P339, DOI 10.1007/s12012-014-9258-y
   Posnack NG, 2012, ENVIRON HEALTH PERSP, V120, P1243, DOI 10.1289/ehp.1205056
   Posnack NG, 2011, TOXICOLOGY, V279, P54, DOI 10.1016/j.tox.2010.09.007
   Rahmani A, 2016, CARDIOVASC TOXICOL, V16, P307, DOI 10.1007/s12012-015-9337-8
   Rameshrad M, 2016, LIFE SCI, V145, P190, DOI 10.1016/j.lfs.2015.12.043
   Rodríguez-Carmona Y, 2019, ENVIRON RES, V169, P26, DOI 10.1016/j.envres.2018.10.014
   Rubin RJ., 1973, Env Heal Perspect, V3, P53, DOI DOI 10.1289/EHP.730353
   Shih MF, 2012, INT J IMMUNOPATH PH, V25, P39, DOI 10.1177/039463201202500106
   Shih MF, 2018, REGUL TOXICOL PHARM, V92, P333, DOI 10.1016/j.yrtph.2017.12.021
   Shih MF, 2015, INT J MOL SCI, V16, P28800, DOI 10.3390/ijms161226131
   Shim YH, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16040671
   Sol CM, 2020, ENVIRON INT, V138, DOI 10.1016/j.envint.2020.105677
   Stojanoska MM, 2017, ENDOCRINE, V55, P666, DOI 10.1007/s12020-016-1158-4
   Sturgeon SR, 2016, INT J HYG ENVIR HEAL, V219, P876, DOI 10.1016/j.ijheh.2016.07.006
   Su TC, 2019, ENVIRON POLLUT, V250, P586, DOI 10.1016/j.envpol.2019.04.006
   Su TC, 2019, ECOTOX ENVIRON SAFE, V173, P37, DOI 10.1016/j.ecoenv.2019.02.021
   Sun GJ, 2019, CHEMOSPHERE, V218, P76, DOI 10.1016/j.chemosphere.2018.11.095
   Sun GJ, 2017, AQUAT TOXICOL, V192, P165, DOI 10.1016/j.aquatox.2017.09.020
   Talsness CE, 2009, PHILOS T R SOC B, V364, P2079, DOI 10.1098/rstb.2008.0281
   Tang CQ, 2018, J APPL TOXICOL, V38, P834, DOI 10.1002/jat.3591
   Trasande L, 2015, HYPERTENSION, V66, P301, DOI 10.1161/HYPERTENSIONAHA.115.05603
   Tsatsakis A.M., 2019, ENCY ENV HLTH, P163, DOI DOI 10.1016/B978-0-12-409548-9.11434-4
   Valvi D, 2015, ENVIRON HEALTH PERSP, V123, P1022, DOI 10.1289/ehp.1408887
   van 't Erve TJ, 2019, ENVIRON SCI TECHNOL, V53, P3258, DOI 10.1021/acs.est.8b05729
   Vanhoutte PM, 2009, ACTA PHYSIOL, V196, P193, DOI 10.1111/j.1748-1716.2009.01964.x
   Wang YD, 2020, ENVIRON POLLUT, V264, DOI 10.1016/j.envpol.2020.114723
   Warembourg C, 2019, J AM COLL CARDIOL, V74, P1317, DOI 10.1016/j.jacc.2019.06.069
   Warembourg C, 2019, INT J HYG ENVIR HEAL, V222, P446, DOI 10.1016/j.ijheh.2018.12.011
   Wei ZZ, 2012, TOXICOL LETT, V212, P212, DOI 10.1016/j.toxlet.2012.05.023
   Werner EF, 2015, ENVIRON HEALTH-GLOB, V14, DOI 10.1186/s12940-015-0062-3
   Wetherill YB, 2007, REPROD TOXICOL, V24, P178, DOI 10.1016/j.reprotox.2007.05.010
   Wiberg B, 2014, ENVIRON RES, V133, P348, DOI 10.1016/j.envres.2014.06.009
   Wittassek M, 2011, MOL NUTR FOOD RES, V55, P7, DOI 10.1002/mnfr.201000121
   Wormuth M, 2006, RISK ANAL, V26, P803, DOI 10.1111/j.1539-6924.2006.00770.x
   Wu XY, 2017, FOOD CHEM TOXICOL, V106, P273, DOI 10.1016/j.fct.2017.05.069
   Xie XM, 2019, ECOTOX ENVIRON SAFE, V174, P75, DOI 10.1016/j.ecoenv.2019.02.067
   Yamaguchi R, 2019, AM J MED SCI, V357, P492, DOI 10.1016/j.amjms.2019.02.012
   Yang G, 2017, HUM EXP TOXICOL, V36, P1177, DOI 10.1177/0960327116681650
   Yao HY, 2016, CHEMOSPHERE, V157, P42, DOI 10.1016/j.chemosphere.2016.05.023
   Zhang SH, 2018, ENVIRON SCI POLLUT R, V25, P15934, DOI 10.1007/s11356-018-1845-1
   Zhang Y, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0178100
   Zhang Y, 2019, ECOTOX ENVIRON SAFE, V183, DOI 10.1016/j.ecoenv.2019.109582
   Zhao JF, 2016, ARCH TOXICOL, V90, P181, DOI 10.1007/s00204-014-1377-5
   Zheng YY, 2020, J HAZARD MATER, V387, DOI 10.1016/j.jhazmat.2019.121696
   Zhou W, 2015, BMC ENDOCR DISORD, V15, DOI 10.1186/s12902-015-0015-4
   Zwierello W, 2020, CHEMOSPHERE, V240, DOI 10.1016/j.chemosphere.2019.124901
NR 98
TC 67
Z9 69
U1 5
U2 33
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2308-3425
J9 J CARDIOVASC DEV DIS
JI J. Cardiovasc. Dev. Dis.
PD SEP
PY 2020
VL 7
IS 3
AR 26
DI 10.3390/jcdd7030026
PG 19
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA OB1DG
UT WOS:000578214700001
PM 32707888
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Taneja, SK
   Singh, KB
AF Taneja, Satish Kumar
   Singh, Kshetrimatyum Birla
TI Beneficial effects of modified egg on oxidative stress in
   F1-generation of metabolic syndrome-X induced Wistar rat
SO INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY
LA English
DT Article
DE Cu; Diabetes mellitus; Omega-3 fatty acids; Mg; Mn; Modified egg;
   Oxidative stress; Vitamin-E; Zn
ID DENSITY LIPOPROTEIN-CHOLESTEROL; DEPENDENT DIABETES-MELLITUS; VITAMIN-E;
   ANTIOXIDANT STATUS; ZINC STATUS; ENZYMATIC DETERMINATION; SERUM
   TRIGLYCERIDES; DEFICIENT MICE; SUPPLEMENTATION; COPPER
AB Congenital malformations of neonates are one of the adverse effects of diabetic pregnancy which can be prevented by supplementation of vitamin E and C. The survived neonates usually are at higher risk to diabetes, hypertension, dyslipidemia and cardiovascular diseases that may possibly be prevented through antioxidants administration. In view of this information, the efficacy of modified poultry egg enriched with optimum minerals, vitamin E and omega-3 fatty acids was studied on F-1-generation, which were made to survive by feeding them this modified egg to diabetic mothers of Wistar rats. The survived F-1-generation displayed hyperglycemia, dyslipidemia and hypertension like their parents, evaluated after three months of the experiment. Their mineral status revealed a higher Zn and lower Cu, Mg and Mn levels in liver and kidney. Their lipid peroxidation products were however higher and the enzyme activities of superoxide dismutase, catalase, glutathione-S-transferase, glutathione reductase, glutathione (reduced) and glucose-6 phosphate dehydrogenase were significantly lower. In the other group of F-1-generation, fed modified egg mixed diet, a significant reduction in the blood pressure, serum glucose, serum lipid profile, and the lipid peroxidation products, and a significant increase in the activities of enzymes per se with reversal of Zn, Cu, Mg and Mn levels closer to the control group were recorded. The data suggest that the
C1 [Taneja, Satish Kumar; Singh, Kshetrimatyum Birla] Panjab Univ, Dept Zool, Chandigarh 160014, India.
C3 Panjab University
RP Taneja, SK (corresponding author), Panjab Univ, Dept Zool, Chandigarh 160014, India.
EM sktaneja@gmail.com
FU University Grants Commission, New Delhi
FX Thanks are due to Mr. Sandeep Barisal from Jaya Health Care Poultry Farm
   (Panchkula, Haryana, India) for providing the infrastructure to rear the
   birds. Financial aid provided by University Grants Commission, New Delhi
   under Special Assistance Programme, Phase-III to the Zoology Department
   and research fellowship to K. Birla Singh provided by UGC is gratefully
   acknowledged. It is certified that there is no conflicts of interest
   between the authors and the various funding agencies.
CR ALLAIN CC, 1974, CLIN CHEM, V20, P470
   Altomare E, 1997, EUR J CLIN INVEST, V27, P141, DOI 10.1046/j.1365-2362.1997.780629.x
   Anderson RA, 2001, J AM COLL NUTR, V20, P212, DOI 10.1080/07315724.2001.10719034
   [Anonymous], 1983, Methods of Enzymatic Analysis
   [Anonymous], 1971, METHODS ENZYMATIC AN
   Baltaci AK, 2005, BIOL TRACE ELEM RES, V104, P41, DOI 10.1385/BTER:104:1:041
   BARTLETT GR, 1959, J BIOL CHEM, V234, P466
   BLACK MR, 1988, AM J CLIN NUTR, V47, P970, DOI 10.1093/ajcn/47.6.970
   Buege J A, 1978, Methods Enzymol, V52, P302
   BURSTEIN M, 1970, J LIPID RES, V11, P583
   Cederberg J, 2001, PEDIATR RES, V49, P755, DOI 10.1203/00006450-200106000-00007
   CHANDRA RK, 1984, JAMA-J AM MED ASSOC, V252, P1443, DOI 10.1001/jama.252.11.1443
   Chausmer AB, 1998, J AM COLL NUTR, V17, P109, DOI 10.1080/07315724.1998.10718735
   CUNNINGHAM JJ, 1994, METABOLISM, V43, P1558, DOI 10.1016/0026-0495(94)90016-7
   DEUCHAR EM, 1979, NCIV APPROACHED STUD, V53, P213
   ELHAGE S, 1990, DEV GENET, V11, P149, DOI 10.1002/dvg.1020110205
   ELLMAN GL, 1959, ARCH BIOCHEM BIOPHYS, V82, P70, DOI 10.1016/0003-9861(59)90090-6
   ERIKSSON UJ, 1985, ACTA ENDOCRINOL-COP, V180, P354
   Evans P, 2001, BRIT J NUTR, V85, pS67, DOI 10.1079/BJN2000296
   FAILLA ML, 1981, J NUTR, V111, P1900, DOI 10.1093/jn/111.11.1900
   FAILLA ML, 1985, P SOC EXP BIOL MED, V180, P317
   FAURE P, 1992, BIOL TRACE ELEM RES, V32, P305, DOI 10.1007/BF02784615
   FISHER KD, 1985, AM J CLIN NUTR, V42, P1318
   FOSSATI P, 1982, CLIN CHEM, V28, P2077
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   FRINGS CS, 1970, AM J CLIN PATHOL, V53, P89
   HABIG WH, 1974, J BIOL CHEM, V249, P7130
   HOOPER PL, 1980, JAMA-J AM MED ASSOC, V244, P1960, DOI 10.1001/jama.244.17.1960
   HUNT J, 1991, FREE RADICAL RES COM, V191, P759
   KATHERINE LO, 1994, AM J CLIN NUTR, V59, P654
   King JC, 2000, AM J CLIN NUTR, V71, p1334S, DOI 10.1093/ajcn/71.5.1334s
   KOO SI, 1977, J NUTR, V107, P909, DOI 10.1093/jn/107.5.909
   Lee L, 2001, J NUTR SCI VITAMINOL, V47, P323, DOI 10.3177/jnsv.47.323
   Lohr GW, 1963, METHOD ENZYMAT AN, P744
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   Maughan RJ, 1999, BRIT MED BULL, V55, P683, DOI 10.1258/0007142991902556
   Maxwell SRJ, 1997, EUR J CLIN INVEST, V27, P484, DOI 10.1046/j.1365-2362.1997.1390687.x
   MCGOWAN MW, 1983, CLIN CHEM, V29, P538
   MOORADIAN AD, 1995, BRAIN RES, V671, P164, DOI 10.1016/0006-8993(94)01327-E
   MORAN JR, 1985, LIFE SCI, V36, P2515, DOI 10.1016/0024-3205(85)90148-1
   MUHAMMAD A, 2003, J AYUB MED COLL ABBO, V15, P1
   NISHIKIMI M, 1972, BIOCHEM BIOPH RES CO, V46, P849, DOI 10.1016/S0006-291X(72)80218-3
   POMP D, 1992, Journal of Animal Science, V70, P198
   Pomp D, 1996, TRANSGENIC RES, V5, P13, DOI 10.1007/BF01979918
   Prohaska JR, 1997, J NUTR BIOCHEM, V8, P316, DOI 10.1016/S0955-2863(97)84447-6
   PROHASKA JR, 1991, J NUTR, V121, P355, DOI 10.1093/jn/121.3.355
   RAHBANINOBAR ME, 1999, MED J ISLAMIC ACAD S, V12, P2012
   ROESCHLA.P, 1974, Z KLIN CHEM KLIN BIO, V12, P226
   Ruiz C, 1998, J TRACE ELEM MED BIO, V12, P91, DOI 10.1016/S0946-672X(98)80031-X
   Sailaja YR, 2003, FREE RADICAL BIO MED, V35, P133, DOI 10.1016/S0891-5849(03)00071-6
   Siman CM, 1997, DIABETES, V46, P1054, DOI 10.2337/diabetes.46.6.1054
   Siman CM, 1997, DIABETOLOGIA, V40, P1416, DOI 10.1007/s001250050844
   STRAIN JJ, 1991, P NUTR SOC, V50, P591, DOI 10.1079/PNS19910073
   Taneja S. K., 2006, Indian Journal of Experimental Biology, V44, P705
   Taneja S. K., 2007, Natural Product Radiance, V6, P22
   Taneja S. K., 2006, Indian Journal of Experimental Biology, V44, P863
   Taneja SK, 2008, BIOL TRACE ELEM RES, V121, P106, DOI 10.1007/s12011-007-8035-1
   TANEJA SK, 1992, BRIT J NUTR, V68, P505, DOI 10.1079/BJN19920108
   Taneja SK, 1998, BIOL TRACE ELEM RES, V62, P255, DOI 10.1007/BF02783975
   Taneja SK, 2000, BIOL TRACE ELEM RES, V75, P177, DOI 10.1385/BTER:75:1-3:177
   Trinder P., 1969, Journal of Clinical Pathology, V22, P158, DOI 10.1136/jcp.22.2.158
   TROCINO RA, 1995, DIABETES, V44, P992, DOI 10.2337/diabetes.44.8.992
   URIUHARE JY, 1985, DIABETES, V34, P1031, DOI 10.2337/diabetes.34.10.1031
   vanDam PS, 1998, FREE RADICAL BIO MED, V24, P18, DOI 10.1016/S0891-5849(97)00122-6
   Viana M, 2003, ANN NUTR METAB, V47, P6, DOI 10.1159/000068907
   WALTER RM, 1991, DIABETES CARE, V14, P1050, DOI 10.2337/diacare.14.11.1050
NR 66
TC 5
Z9 5
U1 0
U2 4
PU NATL INST SCIENCE COMMUNICATION-NISCAIR
PI NEW DELHI
PA DR K S KRISHNAN MARG, PUSA CAMPUS, NEW DELHI 110 012, INDIA
SN 0019-5189
EI 0975-1009
J9 INDIAN J EXP BIOL
JI Indian J. Exp. Biol.
PD FEB
PY 2009
VL 47
IS 2
BP 104
EP 112
PG 9
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA 404HO
UT WOS:000263142500004
PM 19374165
DA 2025-06-11
ER

PT J
AU Shao, XZ
   Dai, HF
   Zhu, LL
AF Shao, Xiangzhi
   Dai, Huifang
   Zhu, Lielie
TI Correlation between estimated glucose disposal rate and diabetic
   depression: a population-based study
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE depression; insulin resistance; waist circumference; diabetes; estimated
   glucose disposal rate
ID INSULIN-RESISTANCE; COMORBID DEPRESSION; METABOLIC SYNDROME; TYPE-1;
   ASSOCIATION; INDEX; MORTALITY; MELLITUS; EVENTS; ADULTS
AB Background Emerging evidence has identified a correlation between depression and insulin resistance (IR). This study aims to explore the correlation between estimated glucose disposal rate (eGDR)-a noninvasive and practical measure of IR-and depression in patients with diabetes mellitus (DM).Methods In this cross-sectional study, the data from 3,080 adults aged 18 years old or older with DM obtained from NHANES 1999-2018 were analyzed. The correlation between eGDR and depression were examined through multivariate logistic regression, subgroup analyses, restricted cubic spline (RCS) analysis, and interaction tests. Additionally, mediation analysis was conducted to assess whether leukocytes and neutrophils could mediate the effects of eGDR on depression.Results Multivariate logistic regression and RCS analyses demonstrate that eGDR was negative linearly correlated with diabetic depression (OR= 0.89; 95% CI: 0.84, 0.95). Patients with DM in Q3 and Q4 of eGDR exhibited a reduced risk of 28% and 54%, respectively, in depression, compared to those in Q1. Subgroup analyses, stratified by variables such as gender, BMI, age, education level, and medical comorbidities, consistently showed a negative correlation. Mediation analysis further indicates that neutrophils and leukocytes accounted for 4.0% and 3.6% of the correlation between eGDR and depression, respectively.Conclusions The results of this study demonstrated a statistically significant inverse linear correlation between eGDR and the prevalence of depression in patients with DM, with leukocytes and neutrophils acting as mediating factors in this correlation.
C1 [Shao, Xiangzhi; Zhu, Lielie] Zhejiang Chinese Med Univ, Dept Rehabil, Wenzhou TCM Hosp, Wenzhou, Zhejiang, Peoples R China.
   [Dai, Huifang] Wenzhou Med Univ, Affiliated Hosp 2, Dept Endocrinol, Wenzhou, Zhejiang, Peoples R China.
   [Dai, Huifang] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Zhejiang, Peoples R China.
C3 Zhejiang Chinese Medical University; Wenzhou Medical University; Wenzhou
   Medical University
RP Zhu, LL (corresponding author), Zhejiang Chinese Med Univ, Dept Rehabil, Wenzhou TCM Hosp, Wenzhou, Zhejiang, Peoples R China.
EM eillie@126.com
OI Zhu, Lielie/0000-0002-7263-3224
FX The author(s) declare that no financial support was received for the
   research and/or publication of this article.
CR Adriaanse MC, 2006, DIABETOLOGIA, V49, P2874, DOI 10.1007/s00125-006-0500-4
   Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   Levis Brooke, 2019, BMJ, V365, pl1476, DOI [10.1136/bmj.l1781, 10.1136/bmj.l1476]
   Brown AE, 2016, CURR CARDIOL REP, V18, DOI 10.1007/s11886-016-0755-4
   Cannon A, 2018, J MANAG CARE SPEC PH, V24, pS5, DOI 10.18553/jmcp.2018.24.9-a.s5
   Chen SG, 2016, ENDOCRINE, V53, P35, DOI 10.1007/s12020-016-0869-x
   Chen WQ, 2022, TRENDS NEUROSCI, V45, P384, DOI 10.1016/j.tins.2022.03.001
   Chen YY, 2024, BMC PSYCHIATRY, V24, DOI 10.1186/s12888-024-06257-2
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Elsayed NA, 2025, DIABETES CARE, V48, pS27, DOI 10.2337/dc25-S002
   Epstein EJ, 2013, DIABETES CARE, V36, P2280, DOI 10.2337/dc12-1693
   Gao SD, 2021, NUTR METAB CARDIOVAS, V31, P3184, DOI 10.1016/j.numecd.2021.07.027
   Geraets AFJ, 2020, DIABETOLOGIA, V63, P2315, DOI 10.1007/s00125-020-05247-9
   Gilsanz P, 2018, DIABETES CARE, V41, P446, DOI 10.2337/dc17-1566
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Inker LA, 2012, NEW ENGL J MED, V367, P20, DOI 10.1056/NEJMoa1114248
   Jin X, 2022, BMC CARDIOVASC DISOR, V22, DOI 10.1186/s12872-022-02817-0
   Kong XF, 2024, ACTA DIABETOL, V61, P1413, DOI 10.1007/s00592-024-02305-1
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Lee JH, 2017, J AFFECT DISORDERS, V208, P553, DOI 10.1016/j.jad.2016.10.027
   Li CM, 2024, DIABETOL METAB SYNDR, V16, DOI 10.1186/s13098-024-01353-5
   Liu C, 2022, DIABETOL METAB SYNDR, V14, DOI 10.1186/s13098-022-00915-9
   Lu ZZ, 2023, CARDIOVASC DIABETOL, V22, DOI 10.1186/s12933-023-01925-1
   Matsubara M, 2020, DIABETES THER, V11, P2729, DOI 10.1007/s13300-020-00916-9
   Maury E, 2010, MOL CELL ENDOCRINOL, V314, P1, DOI 10.1016/j.mce.2009.07.031
   McGown C, 2014, CLIN LIVER DIS, V18, P41, DOI 10.1016/j.cld.2013.09.012
   Meng CQ, 2023, DIABET METAB SYND OB, V16, P807, DOI 10.2147/DMSO.S395818
   Musselman DL, 2003, BIOL PSYCHIAT, V54, P317, DOI 10.1016/S0006-3223(03)00569-9
   Nyström T, 2018, DIABETES OBES METAB, V20, P556, DOI 10.1111/dom.13110
   Olson JC, 2002, METABOLISM, V51, P248, DOI 10.1053/meta.2002.30021
   Otte C, 2016, NAT REV DIS PRIMERS, V2, DOI 10.1038/nrdp.2016.65
   Pané A, 2020, DIABETES-METAB RES, V36, DOI 10.1002/dmrr.3323
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Penno G, 2021, BMC MED, V19, DOI 10.1186/s12916-021-01936-3
   Ren X, 2022, BMC GERIATR, V22, DOI 10.1186/s12877-022-03689-x
   Riggin L, 2020, CAN J DIABETES, V44, P566, DOI 10.1016/j.jcjd.2020.06.014
   Shangguan TT, 2025, FRONT PSYCHIATRY, V16, DOI 10.3389/fpsyt.2025.1504123
   Shelton RC, 2010, PROG NEUROBIOL, V91, P275, DOI 10.1016/j.pneurobio.2010.04.004
   Wahlqvist ML, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-150
   Wallace TM, 2002, DIABETIC MED, V19, P527, DOI 10.1046/j.1464-5491.2002.00745.x
   Wang J, 2021, CLIN INTERV AGING, V16, P97, DOI 10.2147/CIA.S285000
   Watson KT, 2021, JAMA PSYCHIAT, V78, P439, DOI 10.1001/jamapsychiatry.2020.3669
   Whelton Paul K, 2018, Hypertension, V71, pe13, DOI [10.1016/j.jash.2018.06.010, 10.1161/HYP.0000000000000065]
   Williams KV, 2000, DIABETES, V49, P626, DOI 10.2337/diabetes.49.4.626
   Wong J, 2020, CAN J DIABETES, V44, P455, DOI 10.1016/j.jcjd.2020.03.013
   Xing DW, 2025, DIABETOL METAB SYNDR, V17, DOI 10.1186/s13098-024-01574-8
   Zabala A, 2021, CARDIOVASC DIABETOL, V20, DOI 10.1186/s12933-021-01394-4
   Zhang MY, 2025, BMC PUBLIC HEALTH, V25, DOI 10.1186/s12889-025-21734-3
   Zhou XH, 2024, J DIABETES INVEST, V15, P762, DOI 10.1111/jdi.14170
   Zipf George, 2013, Vital Health Stat 1, P1
NR 50
TC 0
Z9 0
U1 1
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD MAR 25
PY 2025
VL 16
AR 1507280
DI 10.3389/fpsyt.2025.1507280
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 1BH2C
UT WOS:001460932800001
PM 40201064
OA gold
DA 2025-06-11
ER

PT J
AU Hansel, B
   Giral, P
   Nobecourt, E
   Chantepie, S
   Bruckert, E
   Chapman, MJ
   Kontush, A
AF Hansel, B
   Giral, P
   Nobecourt, E
   Chantepie, S
   Bruckert, E
   Chapman, MJ
   Kontush, A
TI Metabolic syndrome is associated with elevated oxidative stress and
   dysfunctional dense high-density lipoprotein particles displaying
   impaired antioxidative activity
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID APOLIPOPROTEIN-A-I; DEPENDENT DIABETES-MELLITUS; INSULIN-RESISTANCE;
   ABNORMAL COMPOSITION; LDL OXIDATION; PLASMA LDL; INHIBITS 3; HDL;
   DISEASE; HYPERTRIGLYCERIDEMIA
AB A metabolic syndrome (MetS) phenotype is characterized by insulin-resistance, atherogenic dyslipidemia, oxidative stress, and elevated cardiovascular risk and frequently involves subnormal levels of high-density lipoprotein (HDL) cholesterol. We evaluated the capacity of physicochemically distinct HDL subfractions from MetS subjects to protect low-density lipoprotein against oxidative stress.
   MetS subjects presented an insulin-resistant phenotype, with central obesity and elevation in systolic blood pressure and plasma triglyceride, LDL-cholesterol, apolipoprotein B, glucose, and insulin levels. Systemic oxidative stress, assessed as plasma 8-isoprostanes, was significantly higher (3.7-fold) in MetS subjects ( n = 10) compared with nonobese normolipidemic controls ( n = 11). In MetS, small, dense HDL3a, 3b, and 3c subfractions possessed significantly lower specific antioxidative activity ( up to - 23%, on a unit particle mass basis) than their counterparts in controls. In addition, HDL2a and 3a subfractions from MetS patients possessed lower total antioxidative activity ( up to - 41%, at equivalent plasma concentrations). The attenuated antioxidative activity of small, dense HDL subfractions correlated with systemic oxidative stress and insulin resistance and was associated with HDL particles exhibiting altered physicochemical properties ( core triglyceride enrichment and cholesteryl ester depletion).
   We conclude that antioxidative activity of small, dense HDL subfractions of altered chemical composition is impaired in MetS and associated with elevated oxidative stress and insulin resistance. Induction of selective increase in the circulating concentrations of dense HDL subfractions may represent an innovative therapeutic approach for the attenuation of high cardiovascular risk in MetS.
C1 Hop La Pitie Salpetriere, INSERM, Natl Inst Hlth & Med Res, Dyslipoprot & Atherosclerosis Res Unit, F-75013 Paris, France.
   Hop La Pitie Salpetriere, Serv Endocrinol Metab, F-75013 Paris, France.
C3 Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Pitie-Salpetriere - APHP; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Sorbonne Universite; Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere
   - APHP
RP Kontush, A (corresponding author), Hop La Pitie Salpetriere, INSERM, U551, Pavillon Benjamin Delessert,83 Blvd Hop, F-75651 Paris 13, France.
EM kontush@chups.jussieu.fr
RI Kontush, Anatol/J-2198-2016; chapman, john/Y-2742-2019
OI CHANTEPIE-LABORDE, Sandrine/0000-0003-1652-432X; Kontush,
   Anatol/0000-0002-9008-7335
CR ABBOTT CA, 1995, ARTERIOSCL THROM VAS, V15, P1812, DOI 10.1161/01.ATV.15.11.1812
   Adeli K, 2001, TRENDS CARDIOVAS MED, V11, P170, DOI 10.1016/S1050-1738(01)00084-6
   Alexander CM, 2003, DIABETES, V52, P1210, DOI 10.2337/diabetes.52.5.1210
   Arcaro G, 2002, CIRCULATION, V105, P576, DOI 10.1161/hc0502.103333
   Assmann G, 2003, ANNU REV MED, V54, P321, DOI 10.1146/annurev.med.54.101601.152409
   Bae JH, 2001, ATHEROSCLEROSIS, V155, P517, DOI 10.1016/S0021-9150(00)00601-8
   BAGDADE JD, 1990, ARTERIOSCLEROSIS, V10, P232, DOI 10.1161/01.ATV.10.2.232
   BIESBROECK RC, 1982, DIABETES, V31, P126, DOI 10.2337/diab.31.2.126
   Bonora E, 2002, DIABETES CARE, V25, P1135, DOI 10.2337/diacare.25.7.1135
   Brasier AR, 2002, ARTERIOSCL THROM VAS, V22, P1257, DOI 10.1161/01.ATV.0000021412.56621.A2
   Brunzell JD, 2003, AM J MED, V115, P24, DOI 10.1016/j.amjmed.2003.08.011
   Chancharme L, 1999, ARTERIOSCL THROM VAS, V19, P810, DOI 10.1161/01.ATV.19.3.810
   Chapman MJ, 2003, ATHEROSCLEROSIS, V171, P1, DOI 10.1016/S0021-9150(03)00156-4
   CHAPMAN MJ, 1981, J LIPID RES, V22, P339
   Curtiss LK, 2000, BIOCHEMISTRY-US, V39, P5712, DOI 10.1021/bi992902m
   DECOSSIN C, 1995, BBA-LIPID LIPID MET, V1255, P31, DOI 10.1016/0005-2760(94)00213-I
   Durrington PN, 2001, ARTERIOSCL THROM VAS, V21, P473, DOI 10.1161/01.ATV.21.4.473
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Frank PG, 2000, J LIPID RES, V41, P853
   Goulinet S, 1997, ARTERIOSCL THROM VAS, V17, P786, DOI 10.1161/01.ATV.17.4.786
   Gowri MS, 1999, ARTERIOSCL THROM VAS, V19, P2226, DOI 10.1161/01.ATV.19.9.2226
   Goyal J, 1997, J BIOL CHEM, V272, P16231, DOI 10.1074/jbc.272.26.16231
   Hedrick CC, 2000, DIABETOLOGIA, V43, P312, DOI 10.1007/s001250050049
   HIRAMATSU K, 1988, DIABETES, V37, P832, DOI 10.2337/diabetes.37.6.832
   Huang JM, 1998, CLIN BIOCHEM, V31, P537, DOI 10.1016/S0009-9120(98)00060-5
   KLIMOV AN, 1993, ATHEROSCLEROSIS, V100, P13, DOI 10.1016/0021-9150(93)90063-Z
   Kontush A, 2004, ARTERIOSCL THROM VAS, V24, P526, DOI 10.1161/01.ATV.0000118276.87061.00
   Kontush A, 2003, ARTERIOSCL THROM VAS, V23, P1881, DOI 10.1161/01.ATV.0000091338.93223.E8
   KONTUSH A, 1995, BBA-LIPID LIPID MET, V1258, P177, DOI 10.1016/0005-2760(95)00115-S
   Kudolo GB, 1997, J LIPID MEDIAT CELL, V17, P97, DOI 10.1016/S0929-7855(97)00023-0
   KUNITAKE ST, 1992, P NATL ACAD SCI USA, V89, P6993, DOI 10.1073/pnas.89.15.6993
   MACKNESS MI, 1995, ATHEROSCLEROSIS, V115, P243, DOI 10.1016/0021-9150(94)05524-M
   Maxwell SRJ, 1997, EUR J CLIN INVEST, V27, P484, DOI 10.1046/j.1365-2362.1997.1390687.x
   Mezzetti A, 2000, CARDIOVASC RES, V47, P475, DOI 10.1016/S0008-6363(00)00118-8
   Navab M, 2000, J LIPID RES, V41, P1481
   Navab M, 2000, J LIPID RES, V41, P1495
   OBERLEY LW, 1988, FREE RADICAL BIO MED, V5, P113, DOI 10.1016/0891-5849(88)90036-6
   Panarotto D, 2002, EUR J CLIN INVEST, V32, P84, DOI 10.1046/j.1365-2362.2002.00945.x
   PARTHASARATHY S, 1990, BIOCHIM BIOPHYS ACTA, V1044, P275, DOI 10.1016/0005-2760(90)90314-N
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Redón J, 2003, HYPERTENSION, V41, P1096, DOI 10.1161/01.HYP.0000068370.21009.38
   RUMSEY SC, 1994, J LIPID RES, V35, P1592
   Ruotolo Giacomo, 2002, Curr Cardiol Rep, V4, P494, DOI 10.1007/s11886-002-0113-6
   Sentí M, 2003, J CLIN ENDOCR METAB, V88, P5422, DOI 10.1210/jc.2003-030648
   Sies H, 1997, EXP PHYSIOL, V82, P291, DOI 10.1113/expphysiol.1997.sp004024
   SOLA R, 1990, BIOCHIM BIOPHYS ACTA, V1043, P43, DOI 10.1016/0005-2760(90)90108-A
   Thérond P, 1999, ARCH BIOCHEM BIOPHYS, V362, P139, DOI 10.1006/abbi.1998.0997
   Tsimihodimos V, 2002, ARTERIOSCL THROM VAS, V22, P306, DOI 10.1161/hq0202.102918
   Van Lenten BJ, 2001, TRENDS CARDIOVAS MED, V11, P155, DOI 10.1016/S1050-1738(01)00095-0
   Yoshikawa M, 1997, CLIN BIOCHEM, V30, P221, DOI 10.1016/S0009-9120(97)00031-3
   Zalba G, 2001, HYPERTENSION, V38, P1395, DOI 10.1161/hy1201.099611
NR 51
TC 348
Z9 398
U1 0
U2 6
PU ENDOCRINE SOC
PI CHEVY CHASE
PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA
SN 0021-972X
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD OCT
PY 2004
VL 89
IS 10
BP 4963
EP 4971
DI 10.1210/jc.2004-0305
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 860EW
UT WOS:000224326300029
PM 15472192
OA Bronze
DA 2025-06-11
ER

PT J
AU Geraets, AFJ
   Koehler, S
   Schram, MT
AF Geraets, Anouk F. J.
   Koehler, Sebastian
   Schram, Miranda T.
TI Vascular and metabolic risk factors of late-life depression
SO VESSEL PLUS
LA English
DT Review
DE Depression; etiology; cerebral small vessel disease; microvascular
   dysfunction; metabolic syndrome; diabetes; inflammation;
   neurodegeneration
ID SMALL VESSEL DISEASE; C-REACTIVE PROTEIN; LOW-GRADE INFLAMMATION;
   GENERAL ELDERLY POPULATION; MICROVASCULAR DYSFUNCTION; ENDOTHELIAL
   DYSFUNCTION; BRAIN CHANGES; LATE-ONSET; ASSOCIATION; SYMPTOMS
AB Late-life depression (LLD) is a common complex mood disorder with high comorbidity of both psychiatric and physical diseases, cognitive decline, and increased mortality. The mechanisms underlying LLD are incompletely understood. The heterogeneity of depression complicates research into the underlying mechanisms, and factors involved in LLD may differ from those involved in early-life depression. This narrative review provides an overview of (micro-)vascular and metabolic factors involved in the development of LLD. Evidence suggests that cerebral small vessel disease, generalized microvascular dysfunction, and metabolic risk factors, including diabetes and inflammation, may contribute to the development of LLD, while the role of neurodegeneration needs further indepth investigation. Accordingly, vascular and metabolic factors may provide promising targets for the prevention and improvement of treatment of LLD. Guidelines to screen for LLD in cardiovascular care need further implementation, as do integrated care approaches that treat LLD and diabetes jointly. However, intervention studies are needed to assess which interventions are appropriate and most effective in clinical practice.
C1 [Geraets, Anouk F. J.; Koehler, Sebastian; Schram, Miranda T.] Maastricht Univ, Med Ctr MUMC, Peter Debyelaan 25, NL-6229 HX Maastricht, Netherlands.
C3 Maastricht University; Maastricht University Medical Centre (MUMC)
RP Schram, MT (corresponding author), Maastricht Univ, Med Ctr MUMC, Dept Med, Maastricht Study, Randwycksingel 35, NL-6229 EG Maastricht, Netherlands.
EM m.schram@maastrichtuniversity.nl
RI Geraets, Anouk/ACI-9551-2022
OI Geraets, Anouk/0000-0002-2648-4424
CR Aird WC, 2007, CIRC RES, V100, P158, DOI 10.1161/01.RES.0000255691.76142.4a
   Aizenstein HJ, 2016, BMC MED, V14, DOI 10.1186/s12916-016-0720-5
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alexapoulos GS, 2005, LANCET, V365, P1961, DOI 10.1016/S0140-6736(05)66665-2
   Alexopoulos GS, 2019, TRANSL PSYCHIAT, V9, DOI 10.1038/s41398-019-0514-6
   Alexopoulos GS, 1997, ARCH GEN PSYCHIAT, V54, P915
   Almeida OP, 2003, PSYCHOL MED, V33, P675, DOI 10.1017/S003329170300758X
   Ambrose JA, 2004, J AM COLL CARDIOL, V43, P1731, DOI 10.1016/j.jacc.2003.12.047
   Banks WA, 2006, NEUROL CLIN, V24, P413, DOI 10.1016/j.ncl.2006.03.009
   Baquero M, 2015, WORLD J CLIN CASES, V3, P682, DOI 10.12998/wjcc.v3.i8.682
   Barents ESE, 2021, NHGStandaard Diabetes mellitus type 2 Dutch treatment guidelines for type 2 diabetes
   Barnes DE, 2012, ARCH GEN PSYCHIAT, V69, P493, DOI 10.1001/archgenpsychiatry.2011.1481
   Baune BT, 2012, PSYCHONEUROENDOCRINO, V37, P1521, DOI 10.1016/j.psyneuen.2012.02.006
   Baune B.T., 2016, Cardiovascular Diseases and Depression: Treatment and Prevention in Psychocardiology
   Bennett S, 2014, MATURITAS, V79, P184, DOI 10.1016/j.maturitas.2014.05.009
   Beran M, 2022, DIABETIC MED, V39, DOI 10.1111/dme.14671
   Biessels GJ, 2020, LANCET NEUROL, V19, P699, DOI 10.1016/S1474-4422(20)30139-3
   Blazer DG, 2003, J GERONTOL A-BIOL, V58, P249
   Burgut F Tuna, 2006, Expert Rev Neurother, V6, P65
   Chocano-Bedoya PO, 2014, J AFFECT DISORDERS, V163, P25, DOI 10.1016/j.jad.2014.03.023
   Comijs HC, 2015, BMC PSYCHIATRY, V15, DOI 10.1186/s12888-015-0401-5
   Copeland WE, 2012, BIOL PSYCHIAT, V71, P15, DOI 10.1016/j.biopsych.2011.09.023
   Cyprien F, 2014, J AFFECT DISORDERS, V165, P16, DOI 10.1016/j.jad.2014.04.040
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   Diniz BS, 2013, BRIT J PSYCHIAT, V202, P329, DOI 10.1192/bjp.bp.112.118307
   Disabato BM, 2012, CURR PSYCHIAT REP, V14, P273, DOI 10.1007/s11920-012-0279-6
   Djernes JK, 2006, ACTA PSYCHIAT SCAND, V113, P372, DOI 10.1111/j.1600-0447.2006.00770.x
   Fluharty M, 2017, NICOTINE TOB RES, V19, P3, DOI 10.1093/ntr/ntw140
   Geraets AFJ, 2021, J AFFECT DISORDERS, V292, P439, DOI 10.1016/j.jad.2021.05.096
   Geraets AFJ, 2020, DIABETOLOGIA, V63, P2315, DOI 10.1007/s00125-020-05247-9
   Geraets AFJ, 2020, HYPERTENSION, V76, P342, DOI 10.1161/HYPERTENSIONAHA.120.15260
   Gudmundsson P, 2015, EUR J NEUROL, V22, P781, DOI 10.1111/ene.12651
   Hall JE., 2011, Guyton and Hall textbook of medical physiology, V12th
   Heintz H, 2020, AM J GERIAT PSYCHIAT, V28, P320, DOI 10.1016/j.jagp.2019.07.015
   Houben AJHM, 2017, J AM SOC NEPHROL, V28, P3461, DOI 10.1681/ASN.2017020157
   Janssen EPCJ, 2021, BRAIN BEHAV IMMUN, V97, P61, DOI 10.1016/j.bbi.2021.06.013
   Janssen EPCJ, 2016, J AM GERIATR SOC, V64, pE201, DOI 10.1111/jgs.14388
   Köhler S, 2015, J AM GERIATR SOC, V63, P692, DOI 10.1111/jgs.13357
   Köhler-Forsherg O, 2019, ACTA PSYCHIAT SCAND, V139, P404, DOI 10.1111/acps.13016
   Krishnan KRR, 1997, AM J PSYCHIAT, V154, P497
   Laborde-Lahoz P, 2015, INT J GERIATR PSYCH, V30, P677, DOI 10.1002/gps.4204
   Lenze EJ, 2001, AM J GERIAT PSYCHIAT, V9, P113, DOI 10.1176/appi.ajgp.9.2.113
   Lenze Eric J, 2008, Dialogues Clin Neurosci, V10, P419
   Leonard BE, 2007, NEUROCHEM RES, V32, P1749, DOI 10.1007/s11064-007-9385-y
   Li WJ, 2020, AM J EPIDEMIOL, V189, P873, DOI 10.1093/aje/kwaa023
   Lichtman JH, 2008, CIRCULATION, V118, P1768, DOI 10.1161/CIRCULATIONAHA.108.190769
   Massardo T, 2021, NEUROPSYCHOBIOLOGY, V80, P214, DOI 10.1159/000508110
   McMurray JJV, 2012, EUR HEART J, V33, P1787, DOI 10.1093/eurheartj/ehs104
   Meurs M, 2016, PSYCHOSOM MED, V78, P233, DOI 10.1097/PSY.0000000000000255
   Nefs G, 2012, DIABETOLOGIA, V55, P608, DOI 10.1007/s00125-011-2411-2
   Nestler EJ, 2002, NEURON, V34, P13, DOI 10.1016/S0896-6273(02)00653-0
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Paroni G, 2017, MOL NEUROBIOL, V54, P1340, DOI 10.1007/s12035-016-9711-y
   Pasco JA, 2010, BRIT J PSYCHIAT, V197, P372, DOI 10.1192/bjp.bp.109.076430
   Perez HCS, 2013, PSYCHIAT RES-NEUROIM, V211, P180, DOI 10.1016/j.pscychresns.2012.06.005
   Perk J, 2012, EUR HEART J, V33, P1635, DOI 10.1093/eurheartj/ehs092
   Petrak F, 2015, LANCET DIABETES ENDO, V3, P472, DOI 10.1016/S2213-8587(15)00045-5
   Romeo HE, 2001, J NEUROIMMUNOL, V115, P91, DOI 10.1016/S0165-5728(01)00270-3
   Roy T, 2012, J AFFECT DISORDERS, V142, pS8, DOI 10.1016/S0165-0327(12)70004-6
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sapolsky RM, 2000, ARCH GEN PSYCHIAT, V57, P925, DOI 10.1001/archpsyc.57.10.925
   Schaakxs R, 2018, LANCET PSYCHIAT, V5, P581, DOI 10.1016/S2215-0366(18)30166-4
   Schiepers OJG, 2005, PROG NEURO-PSYCHOPH, V29, P201, DOI 10.1016/j.pnpbp.2004.11.003
   Schiltz JC, 2002, J NEUROSCI, V22, P5606
   Shu MJ, 2021, STROKE VASC NEUROL, V6, P589, DOI 10.1136/svn-2020-000813
   Souery D, 2006, J CLIN PSYCHIAT, V67, P16
   Stehouwer CDA, 2018, DIABETES, V67, P1729, DOI 10.2337/dbi17-0044
   Stewart A, 2009, Heart, Lung and Circulation, V18, pS5
   Stewart JC, 2009, BRAIN BEHAV IMMUN, V23, P936, DOI 10.1016/j.bbi.2009.04.011
   Strawbridge R, 2015, EUR NEUROPSYCHOPHARM, V25, P1532, DOI 10.1016/j.euroneuro.2015.06.007
   Takeuchi T, 2009, DIABETES METAB, V35, P32, DOI 10.1016/j.diabet.2008.06.006
   Tittmann M, 2014, INT J IMAG SYST TECH, V24, P149, DOI 10.1002/ima.22089
   Tong AH, 2016, ACTA DIABETOL, V53, P589, DOI 10.1007/s00592-016-0845-1
   Trangle M., 2016, Institute for clinical systems improvement. Adult depression in primary care
   Trimbos-instituut, ADDENDUM OUDEREN BIJ DE MDR DEPRESSIE
   Trivedi MH, 2006, AM J PSYCHIAT, V163, P28, DOI 10.1176/appi.ajp.163.1.28
   Valkanova V, 2013, J AFFECT DISORDERS, V150, P736, DOI 10.1016/j.jad.2013.06.004
   van Agtmaal MJM, 2017, JAMA PSYCHIAT, V74, P729, DOI 10.1001/jamapsychiatry.2017.0984
   van den Biggelaar AHJ, 2007, EXP GERONTOL, V42, P693, DOI 10.1016/j.exger.2007.01.011
   van Dooren FEP, 2016, BRAIN BEHAV IMMUN, V56, P390, DOI 10.1016/j.bbi.2016.03.004
   van Dooren FEP, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057058
   van Sloten TT, 2014, PSYCHOL MED, V44, P1403, DOI 10.1017/S0033291713002043
   van Sloten Thomas, 2018, F1000Res, V7, DOI 10.12688/f1000research.13898.1
   van Sloten TT, 2015, AM J PSYCHIAT, V172, P570, DOI 10.1176/appi.ajp.2014.14050578
   Vitkovic L, 2000, MOL PSYCHIATR, V5, P604, DOI 10.1038/sj.mp.4000813
   Wang X, 2013, DIABETES CARE, V36, P166, DOI 10.2337/dc12-0702
   Wardlaw JM, 2013, LANCET NEUROL, V12, P822, DOI 10.1016/S1474-4422(13)70124-8
   Wardlaw JM, 2013, LANCET NEUROL, V12, P483, DOI 10.1016/S1474-4422(13)70060-7
   Wium-Andersen MK, 2013, JAMA PSYCHIAT, V70, P176, DOI 10.1001/2013.jamapsychiatry.102
   World Health Organization, 2017, WHOMSDMER20172
   Young-Hyman D, 2016, DIABETES CARE, V39, P2126, DOI 10.2337/dc16-2053
   Zalli A, 2016, PSYCHOPHARMACOLOGY, V233, P1669, DOI 10.1007/s00213-015-3919-9
   Zunszain PA, 2011, PROG NEURO-PSYCHOPH, V35, P722, DOI 10.1016/j.pnpbp.2010.04.011
NR 93
TC 4
Z9 4
U1 0
U2 0
PU OAE PUBLISHING INC
PI ALHAMBRA
PA 245 E MAIN ST, ST122, ALHAMBRA, CA 91801 USA
EI 2574-1209
J9 VESSEL PLUS
JI Vessel Plus
PY 2022
VL 6
AR 19
DI 10.20517/2574-1209.2021.102
PG 11
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA T0F7U
UT WOS:001401877700001
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mokwatsi, GG
   Schutte, AE
   Kruger, R
AF Mokwatsi, Gontse G.
   Schutte, Aletta E.
   Kruger, Ruan
TI A biomarker of tissue damage, lactate dehydrogenase, is associated with
   fibulin-1 and oxidative stress in blacks: the SAfrEIC study
SO BIOMARKERS
LA English
DT Article
DE sex; extracellular matrix remodeling; tissue damage; ethnicity;
   Cardiovascular disease
ID EXTRACELLULAR-MATRIX ALTERATIONS; BLOOD-PRESSURE; HYPERTENSION;
   AFRICANS; MARKERS
AB Context: Extracellular matrix (ECM) remodeling and oxidative stress is present in hypertension and associated arterial stiffness, but little is known on the physiological link among lactate dehydrogenase (LDH), fibulin-1, and reactive oxygen species (ROS).
   Objective: The objective of this study is to explore the link among a marker of tissue damage (LDH), fibulin-1 (as ECM biomarker), and ROS.
   Methods: We included 316 black and 305 white South Africans and determined the above-mentioned biomarkers along with additional cardiometabolic risk factors.
   Results: LDH associated positively with fibulin-1 (beta = 0.23; p < 0.001) and ROS (beta = 0.11; p = 0.30) in blacks only.
   Conclusion: Our finding suggests that increased circulating levels of LDH may be due to early ECM remodeling and oxidative stress in blacks that are subjected to detrimental and uncontrolled lifestyle risk factors.
C1 [Mokwatsi, Gontse G.; Schutte, Aletta E.; Kruger, Ruan] North West Univ, HART, ZA-2531 Potchefstroom, South Africa.
   [Schutte, Aletta E.] North West Univ, MRC, Fac Hlth Sci, Res Unit Hypertens & Cardiovasc, ZA-2531 Potchefstroom, South Africa.
C3 North West University - South Africa; North West University - South
   Africa
RP Kruger, R (corresponding author), North West Univ, HART, ZA-2531 Potchefstroom, South Africa.
EM ruan.kruger@nwu.ac.za
RI Mokwatsi, Gontse/AFI-8210-2022; Schutte, Aletta/E-5126-2018; Kruger,
   Ruan/N-7618-2015
OI Schutte, Aletta/0000-0001-9217-4937; Kruger, Ruan/0000-0001-7680-2032;
   Mokwatsi, Gontse/0000-0001-6203-3965
FU South African National Research Foundation (NRF) [GUN 2073040];
   North-West University, Potchefstroom, South Africa; Human Research
   Ethics Council of the North-West University [NWU-00038-14-S1]
FX The authors report that they have no conflicts of interest. The authors
   would also like to thank the South African National Research Foundation
   (NRF) [GUN 2073040] and the North-West University, Potchefstroom, South
   Africa. The SAfrEIC study was granted ethics approval from the Human
   Research Ethics Council of the North-West University (NWU-00038-14-S1).
   The authors have nothing to disclose.
CR Argraves WS, 2009, HISTOCHEM CELL BIOL, V132, P559, DOI 10.1007/s00418-009-0628-7
   ARGRAVES WS, 1990, J CELL BIOL, V111, P3155, DOI 10.1083/jcb.111.6.3155
   Bagchi D, 1995, TOXICOLOGY, V104, P129, DOI 10.1016/0300-483X(95)03156-A
   Belue R, 2009, GLOBALIZATION HEALTH, V5, DOI 10.1186/1744-8603-5-10
   Burke A, 2003, PROG CARDIOVASC DIS, V46, P79, DOI 10.1016/S0033-0620(03)00076-8
   Cangemi C, 2014, ADV CLIN CHEM, V67, P245, DOI 10.1016/bs.acc.2014.09.008
   Cangemi C, 2011, CLIN CHEM, V57, P1556, DOI 10.1373/clinchem.2011.162966
   Dahl JS, 2012, J AM HEART ASSOC, V1, DOI 10.1161/JAHA.112.003889
   Devlin T.M., 2002, TXB BIOCH CLIN CORRE, V5th
   Dhalla NS, 2000, J HYPERTENS, V18, P655, DOI 10.1097/00004872-200018060-00002
   Godyna S, 1996, BLOOD, V88, P2569, DOI 10.1182/blood.V88.7.2569.bloodjournal8872569
   GONZALEZFLECHA B, 1993, J CLIN INVEST, V91, P456, DOI 10.1172/JCI116223
   Hamer M, 2010, ATHEROSCLEROSIS, V210, P209, DOI 10.1016/j.atherosclerosis.2010.01.038
   Hinton RB, 2006, CIRC RES, V98, P1431, DOI 10.1161/01.RES.0000224114.65109.4e
   Jacob MP, 2003, BIOMED PHARMACOTHER, V57, P195, DOI 10.1016/S0753-3322(03)00065-9
   Jacob MP, 2001, PATHOL BIOL, V49, P326, DOI 10.1016/S0369-8114(01)00151-1
   Jomova K, 2011, TOXICOLOGY, V283, P65, DOI 10.1016/j.tox.2011.03.001
   Kato GJ, 2006, BLOOD, V107, P2279, DOI 10.1182/blood-2005-06-2373
   Kearney PM, 2005, LANCET, V365, P217, DOI 10.1016/S0140-6736(05)70151-3
   Kruger R, 2012, ATHEROSCLEROSIS, V222, P216, DOI 10.1016/j.atherosclerosis.2012.01.045
   Kruger R, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0101522
   Lee DH, 2004, FREE RADICAL RES, V38, P535, DOI 10.1080/10715760410001694026
   Lee HY, 2010, CIRC J, V74, P2257, DOI 10.1253/circj.CJ-10-0910
   Lee NV, 2005, J BIOL CHEM, V280, P34796, DOI 10.1074/jbc.M506980200
   Lemarié CA, 2010, J MOL CELL CARDIOL, V48, P433, DOI 10.1016/j.yjmcc.2009.09.018
   Norton K., 2004, Anthropometrica: A Textbook of Body Measurement for Sports and Health Courses
   Samir Z., 2006, ALCOHOL RES HEALTH, V29, P245
   Schacker TW, 2002, J CLIN INVEST, V110, P1133, DOI [10.1172/JCI0216413, 10.1172/JCI200216413]
   Scholze A, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-6
   Schutte AE, 2012, INT J EPIDEMIOL, V41, P1114, DOI 10.1093/ije/dys106
   Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
   Verhaar MC, 1998, J HYPERTENS, V16, P45, DOI 10.1097/00004872-199816010-00008
   Wagenseil JE, 2012, J CARDIOVASC TRANSL, V5, P264, DOI 10.1007/s12265-012-9349-8
   Yasmin, 2005, ARTERIOSCL THROM VAS, V25, P372, DOI 10.1161/01.ATV.0000151373.33830.41
   Zatu MC, 2014, J HYPERTENS, V32, P749, DOI 10.1097/HJH.0000000000000093
NR 35
TC 13
Z9 17
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1354-750X
EI 1366-5804
J9 BIOMARKERS
JI Biomarkers
PD JAN 2
PY 2016
VL 21
IS 1
BP 48
EP 55
DI 10.3109/1354750X.2015.1118532
PG 8
WC Biotechnology & Applied Microbiology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Toxicology
GA DI8FN
UT WOS:000373737000002
PM 26631026
DA 2025-06-11
ER

PT J
AU Ibraheem, ZO
   Basir, R
   Aljobory, AK
   Ibrahim, OE
   Alsumaidaee, A
   Yam, MF
AF Ibraheem, Zaid O.
   Basir, Rusliza
   Aljobory, Ahmad Kh.
   Ibrahim, Omar E.
   Alsumaidaee, Ajwad
   Yam, Mun Fee
TI Impact of Gentamicin Coadministration along with High Fructose Feeding
   on Progression of Renal Failure and Metabolic Syndrome in Sprague-Dawley
   Rats
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID INSULIN-RESISTANCE; SODIUM-REABSORPTION; LIVER; NEPHROTOXICITY; ALPHA;
   AMINOGLYCOSIDES; TRIGLYCERIDE; MECHANISM; EXCRETION; STRESS
AB The current study evaluates the impact of high fructose feeding in rat model of gentamicin induced nephrotoxicity. Sprague-Dawley rats weighing 180-200 g were randomized into four groups; (C) received standard rodents chow with free access to ad libitum drinking water for 8 weeks and was considered as control, (F) received standard rodents chow with free access to drinking water supplemented with 20% (W/V) fructose for the same abovementioned period, (FG) was fed as group F and was given 80 mg/kg (bodyweight)/day gentamicin sulphate intraperitoneally during the last 20 days of the feeding period, and (G) was given gentamicin as above and fed as group C. Renal function was assessed at the end of the treatment period through measuring serum creatinine, uric acid and albumin, creatinine clearance, absolute and fractional excretion of both sodium and potassium, twenty-four-hour urinary excretion of albumin, and renal histology. For metabolic syndrome assessment, fasting plasma glucose and insulin were measured and oral glucose tolerance test was performed throughout the treatment period. Results showed that gentamicin enhances progression of fructose induced metabolic syndrome. On the other hand, fructose pretreatment before gentamicin injection produced a comparable degree of renal dysfunction to those which were given fructose-free water but the picture of nephrotoxicity was somewhat altered as it was characterized by higher extent of glomerular congestion and protein urea. Overall, more vigilance is required when nephrotoxic drugs are prescribed for patients with fructose induced metabolic syndrome.
C1 [Ibraheem, Zaid O.; Basir, Rusliza; Yam, Mun Fee] Univ Putra Malaysia, Sch Med & Hlth Sci, Dept Pharmacol & Toxicol, Serdang 47300, Selangor, Malaysia.
   [Ibraheem, Zaid O.; Alsumaidaee, Ajwad] Univ Baghdad, Fac Pharm, Dept Clin Lab Sci, Baghdad, Iraq.
   [Basir, Rusliza] Univ Putra Malaysia, Sch Med & Hlth Sci, Dept Anat, Serdang 47300, Selangor, Malaysia.
   [Aljobory, Ahmad Kh.; Alsumaidaee, Ajwad] Univ Putra Malaysia, Sch Vet Med, Dept Vet Surg, Serdang 47300, Selangor, Malaysia.
   [Ibrahim, Omar E.] Univ Putra Malaysia, Sch Med & Hlth Sci, Dept Pathol, Serdang 47300, Selangor, Malaysia.
   [Ibrahim, Omar E.] Univ Teknol MARA, Sch Dent, Dept Pathol, Shah Alam 48600, Selangor, Malaysia.
C3 Universiti Putra Malaysia; University of Baghdad; Universiti Putra
   Malaysia; Universiti Putra Malaysia; Universiti Putra Malaysia;
   Universiti Teknologi MARA
RP Ibraheem, ZO (corresponding author), Univ Putra Malaysia, Sch Med & Hlth Sci, Dept Pharmacol & Toxicol, Serdang 47300, Selangor, Malaysia.
EM zaid.2002.2005@gmail.com; rusliza@medic.upm.my
RI Ibraheem, zaid/P-9442-2019; Basir, Rusliza/AAP-4070-2021; Yam,
   Mun/E-2862-2012; ibrahim, omar/AGQ-3749-2022
OI Ibrahim, Associate Professor Dr Omar Emad/0000-0001-8200-9727; Basir,
   Rusliza/0000-0003-3363-6630
FU School of medicine and health science/Universiti Putra Malaysia
FX School of medicine and health science/Universiti Putra Malaysia, is
   gratefully acknowledged for financial support.
CR Bezerra RMN, 2000, J NUTR, V130, P1531, DOI 10.1093/jn/130.6.1531
   Bledsoe G, 2008, TOXICOL SCI, V102, P433, DOI 10.1093/toxsci/kfn008
   COJOCEL C, 1983, TOXICOL APPL PHARM, V68, P96, DOI 10.1016/0041-008X(83)90358-7
   CURRY DL, 1989, PANCREAS, V4, P2, DOI 10.1097/00006676-198902000-00002
   Dekker MJ, 2010, AM J PHYSIOL-ENDOC M, V299, pE685, DOI 10.1152/ajpendo.00283.2010
   Elliott C, 2000, CLIN PHARMACOL THER, V67, P16, DOI 10.1067/mcp.2000.103864
   Elliott SS, 2002, AM J CLIN NUTR, V76, P911, DOI 10.1093/ajcn/76.5.911
   Faria AN, 2002, OBES RES, V10, P1203, DOI 10.1038/oby.2002.164
   Glantzounis GK, 2005, CURR PHARM DESIGN, V11, P4145, DOI 10.2174/138161205774913255
   GRUNFELD B, 1995, HYPERTENSION, V26, P1089, DOI 10.1161/01.HYP.26.6.1089
   Guo JJ, 2013, DIGEST DIS SCI, V58, P1004, DOI 10.1007/s10620-012-2516-6
   HALLFRISCH J, 1990, FASEB J, V4, P2652, DOI 10.1096/fasebj.4.9.2189777
   Herlitz H, 1996, NEPHROL DIAL TRANSPL, V11, P47
   Ibraheem ZO, 2011, ADV CLIN EXP MED, V20, P667
   Kanuri G, 2011, J NUTR BIOCHEM, V22, P527, DOI 10.1016/j.jnutbio.2010.04.007
   Levi B, 1998, J NUTR, V128, P1442, DOI 10.1093/jn/128.9.1442
   Lopez-Novoa JM, 2011, KIDNEY INT, V79, P33, DOI 10.1038/ki.2010.337
   MARTINEZ FJ, 1994, HYPERTENSION, V23, P456, DOI 10.1161/01.HYP.23.4.456
   Mingeot-Leclercq MP, 1999, ANTIMICROB AGENTS CH, V43, P1003, DOI 10.1128/AAC.43.5.1003
   Nakagawa T, 2005, NAT CLIN PRACT NEPHR, V1, P80, DOI 10.1038/ncpneph0019
   Noori S, 2009, J ANIM PLANT SCI-PAK, V19, P174
   REINER NE, 1978, J ANTIMICROB CHEMOTH, V4, P85, DOI 10.1093/jac/4.suppl_A.85
   Rodrigues SL, 2009, HYPERTENS RES, V32, P906, DOI 10.1038/hr.2009.122
   Roglans N, 2002, J PHARMACOL EXP THER, V302, P232, DOI 10.1124/jpet.302.1.232
   Roglans N, 2007, HEPATOLOGY, V45, P778, DOI 10.1002/hep.21499
   Shapiro A, 2008, AM J PHYSIOL-REG I, V295, pR1370, DOI 10.1152/ajpregu.00195.2008
   Tan HW, 2008, ACTA PHARMACOL SIN, V29, P1051, DOI 10.1111/j.1745-7254.2008.00843.x
   Teff KL, 2009, J CLIN ENDOCR METAB, V94, P1562, DOI 10.1210/jc.2008-2192
   Wei YR, 2005, J NUTR, V135, P1642, DOI 10.1093/jn/135.7.1642
   Wei YR, 2013, NUTR METAB, V10, DOI 10.1186/1743-7075-10-32
   Zennaro MC, 2009, TRENDS ENDOCRIN MET, V20, P444, DOI 10.1016/j.tem.2009.05.006
NR 31
TC 13
Z9 14
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2014
VL 2014
AR 823879
DI 10.1155/2014/823879
PG 10
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA AK7QZ
UT WOS:000338624100001
PM 25045706
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Raeder, MB
   Bjelland, I
   Vollset, SE
   Steen, VM
AF Raeder, Maria B.
   Bjelland, Ingvar
   Vollset, Stein Emil
   Steen, Vidar M.
TI Obesity, dyslipidemia, and diabetes with selective serotonin reuptake
   inhibitors: The Hordaland Health Study
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID DRUGS ACTIVATE SREBP; ANTIDEPRESSANT-DRUGS; DEPRESSIVE SYMPTOMS;
   ANTIPSYCHOTIC-DRUGS; MAJOR DEPRESSION; HOSPITAL ANXIETY; PLASMA-LIPIDS;
   SERUM-LIPIDS; CHOLESTEROL; PREVALENCE
AB Objective: This study aimed to examine whether subjects taking selective serotonin reuptake inhibitors (SSRIs) are more likely to have elements of the metabolic syndrome compared with those taking no psychotropic drugs. For comparison, we also studied subjects taking antipsychotic drugs.
   Method: We used data from The Hordaland Health Study '97-'99, a general community cross-sectional health survey including 25,315 subjects aged 40 to 49 and 70 to 74 years. For the groups studied, we estimated prevalence and odds ratios (ORs) for obesity, hypercholesterolemia, low high-density lipoprotein cholesterol, hypertriglyceridemia, and diabetes.
   Results: We observed an association between use of SSRIs as a group (N = 461) and abdominal obesity (OR = 1.40, 95% CI = 1.08 to 1.81) and hypercholesterolemia (OR = 1.36, 95% CI = 1.07 to 1.73) after adjusting for multiple possible confounders. There was also a trend toward an association between SSRI use and diabetes. In a subgroup analysis of subjects taking SSRIs, the use of paroxetine (N = 187) was markedly associated with both general and abdominal obesity but not with hypercholesterolemia. In contrast, the use of citalopram (N = 142) was not associated with any of the metabolic outcome variables, while the use of any other SSRI (sertraline, fluoxetine, or fluvoxamine) (N = 131) as a mixed subgroup was associated with both abdominal obesity and hypercholesterolemia. We also replicated the previously reported associations between use of antipsychotics and obesity and metabolic disturbances.
   Conclusion: We have shown that use of at least some SSRIs is associated with clinical and biochemical elements of the metabolic syndrome. Our data indicate differences in the metabolic side effect profile among various SSRI drugs, although treatment bias might have influenced these results. We suggest that patients taking SSRIs be carefully monitored for obesity and dyslipidemia.
C1 Haukeland Hosp, Ctr Med Genet & Mol Med, Dr Einar Martens Res Grp Biol Psychiat, Helse Bergen HF, N-5021 Bergen, Norway.
   Univ Bergen, Dept Clin Med, Bergen, Norway.
   Univ Bergen, Bergen Mental Hlth Res Ctr, Bergen, Norway.
   Haukeland Hosp, Dept Child & Adolescent Mental Hlth Serv, N-5021 Bergen, Norway.
   Univ Bergen, Dept Publ Hlth & Primary Care, Sect Epidemiol & Med Stat, Bergen, Norway.
C3 University of Bergen; Haukeland University Hospital; University of
   Bergen; University of Bergen; University of Bergen; Haukeland University
   Hospital; University of Bergen
RP Raeder, MB (corresponding author), Haukeland Hosp, Ctr Med Genet & Mol Med, Dr Einar Martens Res Grp Biol Psychiat, Helse Bergen HF, N-5021 Bergen, Norway.
EM maria.rader@uib.no
RI Abebe, Mesfin/GPF-5732-2022; Steen, Vidar/A-6190-2008
OI Bjelland, Ingvar/0000-0003-1113-8323
CR Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   BERSHAD S, 1985, NEW ENGL J MED, V313, P981, DOI 10.1056/NEJM198510173131604
   Bjelland I, 2002, J PSYCHOSOM RES, V52, P69, DOI 10.1016/S0022-3999(01)00296-3
   Chen CC, 2001, PSYCHIAT RES, V102, P153, DOI 10.1016/S0165-1781(01)00231-1
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Croft H, 1999, CLIN THER, V21, P643, DOI 10.1016/S0149-2918(00)88317-4
   DEJONGHE F, 1991, PHARMACOPSYCHIATRY, V24, P62, DOI 10.1055/s-2007-1014440
   Echevarria KL, 1999, ANN PHARMACOTHER, V33, P859, DOI 10.1345/aph.18174
   Everson-Rose SA, 2004, DIABETES CARE, V27, P2856, DOI 10.2337/diacare.27.12.2856
   Fava M, 2000, J CLIN PSYCHIAT, V61, P863, DOI 10.4088/JCP.v61n1109
   Ferno J, 2005, PHARMACOGENOMICS J, V5, P298, DOI 10.1038/sj.tpj.6500323
   GAVARD JA, 1993, DIABETES CARE, V16, P1167, DOI 10.2337/diacare.16.8.1167
   Gavin JR, 1999, DIABETES CARE, V22, pS5
   Geddes JR, 2000, COCHRANE DB SYST REV
   Helgason T, 2004, BRIT J PSYCHIAT, V184, P157, DOI 10.1192/bjp.184.2.157
   HENRY JA, 1995, BRIT MED J, V310, P221, DOI 10.1136/bmj.310.6974.221
   Heo M, 2006, INT J OBESITY, V30, P513, DOI 10.1038/sj.ijo.0803122
   HUGHES JR, 1986, AM J PSYCHIAT, V143, P993
   Janssen I, 2002, J AM GERIATR SOC, V50, P889, DOI 10.1046/j.1532-5415.2002.50216.x
   LARDINOIS CK, 1988, ARCH INTERN MED, V148, P1280, DOI 10.1001/archinte.148.6.1280
   LASSER NL, 1984, AM J MED, V76, P52, DOI 10.1016/0002-9343(84)90957-4
   Leo RJ, 1996, J CLIN PSYCHIAT, V57, P449, DOI 10.4088/JCP.v57n1002
   Löwe B, 2004, J AFFECT DISORDERS, V78, P131, DOI 10.1016/S0165-0327(02)00237-9
   MACKLE MKJ, 1998, 37 ANN M AM COLL NEU, V56, P204
   Maes M, 1997, ACTA PSYCHIAT SCAND, V95, P212, DOI 10.1111/j.1600-0447.1997.tb09622.x
   Martin RM, 1997, BRIT MED J, V314, P646, DOI 10.1136/bmj.314.7081.646
   Masand Prakash S, 2002, Ann Clin Psychiatry, V14, P175, DOI 10.3109/10401230209147454
   Meyer JM, 2004, SCHIZOPHR RES, V70, P1, DOI 10.1016/j.schres.2004.01.014
   Michelson D, 1999, AM J PSYCHIAT, V156, P1170
   MORGAN RE, 1993, LANCET, V341, P75, DOI 10.1016/0140-6736(93)92556-9
   OLFSON M, 1993, AM J PSYCHIAT, V150, P571
   Partonen T, 1999, BRIT J PSYCHIAT, V175, P259, DOI 10.1192/bjp.175.3.259
   Raeder MB, 2006, MOL CELL BIOCHEM, V289, P167, DOI 10.1007/s11010-006-9160-4
   Raeder MB, 2006, NEUROSCI LETT, V395, P185, DOI 10.1016/j.neulet.2005.10.096
   Sclar DA, 1998, CLIN THER, V20, P871, DOI 10.1016/S0149-2918(98)80148-3
   Steegmans PHA, 2000, PSYCHOSOM MED, V62, P205, DOI 10.1097/00006842-200003000-00009
   Wirshing DA, 2002, J CLIN PSYCHIAT, V63, P856, DOI 10.4088/JCP.v63n1002
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 38
TC 149
Z9 160
U1 2
U2 16
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD DEC
PY 2006
VL 67
IS 12
BP 1974
EP 1982
DI 10.4088/JCP.v67n1219
PG 9
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 120LI
UT WOS:000243085800018
PM 17194277
DA 2025-06-11
ER

PT J
AU Baysal, T
   Alp, H
   Koç, N
   Atabek, ME
   Eklioglu, BS
   Karaarslan, S
AF Baysal, Tamer
   Alp, Hayrullah
   Koc, Nesibe
   Atabek, Mehmet Emre
   Eklioglu, Beray Selver
   Karaarslan, Sevim
TI Serum ischemia-modified albumin level and its association with
   cardiovascular risk factors in obese children and adolescents
SO JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE cardiovascular risk; children and adolescents; epicardial adipose
   tissue; hepatosteotosis; ischemia modified albumin; metabolic syndrome
ID EPICARDIAL ADIPOSE-TISSUE; TYPE-2 DIABETES-MELLITUS; LEFT-VENTRICULAR
   MASS; METABOLIC SYNDROME; OXIDATIVE STRESS; BIOMARKERS; DISEASE; MARKER;
   LIPIDS; INDEX
AB Background: Serum ischemia modified albumin (IMA) levels have been previously studied and found to correlate with some anthropometric and laboratory measurements in adult obesity. IMA had not been studied in obese children and adolescents.
   Objective: The aim of the study is to analyze serum IMA levels and to evaluate their correlation with cardiovascular risk factors in obese children and adolescents with and without metabolic syndrome (MS).
   Subjects and methods: Sixty-one obese children/adolescents and 33 healthy children were included in the study. The obese group was divided into four subgroups, including MS (n=25), non-MS (n=36), liver steatosis (n=19) and non-liver steatosis (n=42) groups. Blood was collected to analyze biochemical parameters and IMA. Epicardial adipose tissue thickness was measured with echocardiography, and liver steotosis was determined with ultrasonography for each subject.
   Results: Body mass index (BMI), waist circumferences (WC), left ventricular mass (LVM) and epicardial adipose tissue (EAT) thickness were significantly higher in obese subjects. Serum IMA levels were significantly higher in the metabolic syndrome (MS) and hepatosteotosis groups. Additionally, LVM and EAT thickness were found to be correlated with serum IMA levels in these groups.
   Conclusions: Our study suggests that serum IMA levels may be used to predict cardiovascular risk in obese children with MS and hepatosteotosis. This may be related to the duration of obesity in childhood ending in adulthood.
C1 [Baysal, Tamer; Alp, Hayrullah; Koc, Nesibe; Karaarslan, Sevim] Necmettin Erbakan Univ, Dept Pediat Cardiol, Meram Sch Med Hosp, Konya, Turkey.
   [Atabek, Mehmet Emre; Eklioglu, Beray Selver] Necmettin Erbakan Univ, Dept Pediat Endocrinol, Meram Sch Med Hosp, Konya, Turkey.
C3 Necmettin Erbakan University; Necmettin Erbakan University
RP Alp, H (corresponding author), Necmettin Erbakan Univ, Dept Pediat Cardiol, Meram Sch Med Hosp, Konya, Turkey.
EM drhayrullahalp@hotmail.com
RI RAYMAN ERGÜN, Ahsen/AGF-6627-2022; Alp, Hayrullah/D-2984-2014; Eren,
   Mehmet/LBI-2705-2024
CR Atabek ME, 2011, J CLIN RES PEDIATR E, V3, P132, DOI 10.4274/jcrpe.v3i3.26
   Bar-Or D, 2000, J EMERG MED, V19, P311, DOI 10.1016/S0736-4679(00)00255-9
   Bundak R, 2006, ACTA PAEDIATR, V95, P194, DOI 10.1080/08035250500334738
   Collinson PO, 2008, J CLIN PATHOL, V61, P1025, DOI 10.1136/jcp.2007.053363
   Dahiya K, 2010, CLIN LAB, V56, P187
   Daniels SR, 2005, CIRCULATION, V111, P1999, DOI 10.1161/01.CIR.0000161369.71722.10
   DEVEREUX RB, 1977, CIRCULATION, V55, P613, DOI 10.1161/01.CIR.55.4.613
   Dhuper S, 2011, OBESITY, V19, P128, DOI 10.1038/oby.2010.134
   Di Bonito P, 2008, NUTR METAB CARDIOVAS, V18, P613, DOI 10.1016/j.numecd.2007.09.002
   Duarte MMMF, 2009, CLIN BIOCHEM, V42, P666, DOI 10.1016/j.clinbiochem.2009.01.010
   Iacobellis G, 2003, J CLIN ENDOCR METAB, V88, P5163, DOI 10.1210/jc.2003-030698
   Iacobellis G, 2011, TRENDS ENDOCRIN MET, V22, P450, DOI 10.1016/j.tem.2011.07.003
   Jiang X, 1996, INT J OBESITY, V20, P951
   Kazanis K, 2011, MATURITAS, V70, P182, DOI 10.1016/j.maturitas.2011.07.009
   Kosti Rena I., 2006, Central European Journal of Public Health, V14, P151
   Lang RM, 2005, J AM SOC ECHOCARDIOG, V18, P1440, DOI 10.1016/j.echo.2005.10.005
   Mehta SK, 2009, CONGENIT HEART DIS, V4, P338, DOI 10.1111/j.1747-0803.2009.00330.x
   Ozdemir O, 2010, PEDIATR CARDIOL, V31, P853, DOI 10.1007/s00246-010-9720-y
   Pacifico L, 2011, WORLD J GASTROENTERO, V17, P3082, DOI 10.3748/wjg.v17.i26.3082
   Piva SJ, 2011, CLIN BIOCHEM, V44, P345, DOI 10.1016/j.clinbiochem.2010.12.001
   Piwowar A, 2008, DIS MARKERS, V24, P311, DOI 10.1155/2008/784313
   QUINN SF, 1985, AM J ROENTGENOL, V145, P753, DOI 10.2214/ajr.145.4.753
   Roy D, 2006, HEART, V92, P113, DOI 10.1136/hrt.2004.049643
   Saritas T, 2010, PEDIATR CARDIOL, V31, P792, DOI 10.1007/s00246-010-9705-x
   Sbarouni E, 2011, CLIN CHEM LAB MED, V49, P177, DOI 10.1515/CCLM.2011.037
   Scott CR, 1997, PEDIATRICS, V100, P84, DOI 10.1542/peds.100.1.84
   Sinha R, 2002, NEW ENGL J MED, V346, P802, DOI 10.1056/NEJMoa012578
   Speiser PW, 2005, J CLIN ENDOCR METAB, V90, P1871, DOI 10.1210/jc.2004-1389
   Turedi S, 2010, J NEPHROL, V23, P335
   Gottlieb MGV, 2010, J CLIN ENDOCR METAB, V95, P586, DOI 10.1210/jc.2009-1592
   Zimmet P, 2007, PEDIATR DIABETES, V8, P299, DOI 10.1111/j.1399-5448.2007.00271.x
NR 31
TC 11
Z9 11
U1 0
U2 10
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0334-018X
J9 J PEDIATR ENDOCR MET
JI J. Pediatr. Endocrinol. Metab.
PD OCT
PY 2012
VL 25
IS 9-10
BP 935
EP 944
DI 10.1515/jpem-2012-0191
PG 10
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA 019RP
UT WOS:000309757300019
PM 23426823
DA 2025-06-11
ER

PT J
AU Sakamoto, K
   Sakamoto, T
   Ogawa, H
AF Sakamoto, Kenji
   Sakamoto, Tomohiro
   Ogawa, Hisao
TI Effects of metabolic risk factors on production of plasminogen activator
   inhibitor-1 and adiponectin by adipocytes
SO CIRCULATION JOURNAL
LA English
DT Article
DE adiponectin; metabolic syndrome; type 1 plasminogen activator inhibitor
   (PAI-1)
ID OXIDATIVE STRESS; EXPRESSION; OBESITY; DISEASE
AB Background Type 1 plasminogen activator inhibitor (PAI-1) and adiponectin are produced by adipocytes and are important in the progression of coronary artery disease (CAD).
   Methods and Results Different concentrations of glucose, insulin and 1% triglycerides were used to assay PAI-1 and adiponectin production from cultured adipocytes. Triglycerides induced the highest PAI-1 production with 16.5 mmol/L glucose and 50 nmol/L insulin. In contrast, glucose and insulin decreased adiponectin production in a dose-dependent manner irrespective of triglycerides.
   Conclusion The metabolic syndrome risk factors alter PAI-1 and adiponectin production by adipocytes, in the presence or absence of triglycerides, which might play a role in the development of CAD.
C1 [Sakamoto, Tomohiro] Saiseikai Kumamoto Hosp, Ctr Cardiovasc, Div Cardiol, Kumamoto 8614193, Japan.
   [Sakamoto, Kenji] Hlth Insurance Yatsushiro Gen Hosp, Div Cardiol, Yatsushiro, Japan.
   [Ogawa, Hisao] Kumamoto Univ, Dept Cardiovasc Med, Grad Sch Med Sci, Kumamoto, Japan.
C3 Saiseikai Kumamoto Hospital; Kumamoto University
RP Sakamoto, T (corresponding author), Saiseikai Kumamoto Hosp, Ctr Cardiovasc, Div Cardiol, 5-3-1 Chikami, Kumamoto 8614193, Japan.
EM tom@kumamoto-u.ac.jp
OI Sakamoto, Kenji/0000-0003-4076-8981
CR Hotta K, 2000, ARTERIOSCL THROM VAS, V20, P1595, DOI 10.1161/01.ATV.20.6.1595
   Kamigaki M, 2006, BIOCHEM BIOPH RES CO, V339, P624, DOI 10.1016/j.bbrc.2005.11.059
   Loskutoff DJ, 1998, ARTERIOSCL THROM VAS, V18, P1, DOI 10.1161/01.ATV.18.1.1
   Lundgren CH, 1996, CIRCULATION, V93, P106, DOI 10.1161/01.CIR.93.1.106
   Maeda K, 1997, GENE, V190, P227, DOI 10.1016/S0378-1119(96)00730-5
   Matsuzawa Y, 1999, ANN NY ACAD SCI, V892, P146, DOI 10.1111/j.1749-6632.1999.tb07793.x
   Sakamoto T, 1999, AM J PHYSIOL-CELL PH, V276, pC1391, DOI 10.1152/ajpcell.1999.276.6.C1391
   Solymoss BC, 2003, CORONARY ARTERY DIS, V14, P207, DOI 10.1097/01.mca.0000065744.52558.9f
   Subauste AR, 2007, AM J PHYSIOL-ENDOC M, V293, pE159, DOI 10.1152/ajpendo.00629.2006
   Zang Y, 2005, OBES RES, V13, P1530, DOI 10.1038/oby.2005.188
NR 10
TC 14
Z9 14
U1 0
U2 0
PU JAPANESE CIRCULATION SOC
PI TOYKO
PA 18TH FLOOR IMPERIAL HOTEL TOWER, 1-1-1 UCHISAIWAI-CHO CHIYODA-KU, TOYKO,
   100-0011, JAPAN
SN 1346-9843
EI 1347-4820
J9 CIRC J
JI Circ. J.
PD MAY
PY 2008
VL 72
IS 5
BP 844
EP 846
DI 10.1253/circj.72.844
PG 3
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 294WM
UT WOS:000255437000026
PM 18441469
OA Bronze
DA 2025-06-11
ER

PT J
AU Salvo, A
   Tuttolomondo, A
AF Salvo, Andrea
   Tuttolomondo, Antonino
TI The Role of Olive Oil in Cardiometabolic Risk
SO METABOLITES
LA English
DT Review
DE olive oil; cardiovascular disease; Mediterranean diet
ID TYPE-2 DIABETES-MELLITUS; REDUCES OXIDATIVE STRESS; MEDITERRANEAN DIET;
   PHENOLIC-COMPOUNDS; BLOOD-PRESSURE; PLATELET ACTIVATION; ADIPOSE-TISSUE;
   ALPHA-AMYLASE; NITRIC-OXIDE; IN-VITRO
AB Olive oil, the primary fat source in the Mediterranean diet (MedDiet), is rich in monounsaturated fatty acids (MUFA), especially oleic acid, which constitutes 70-80% of its composition. Extra-virgin olive oil (EVOO), produced by mechanically pressing olives, is the highest quality olive oil, with an intense flavor and acidity <1%. In contrast, refined olive oil (ROO), a blend of virgin and refined oils, contains fewer antioxidants and anti-inflammatory compounds. EVOO's health benefits stem largely from its MUFA content, which is linked to reduced risks of cardiovascular disease (CVD), neurodegenerative conditions, and certain cancers. Additionally, EVOO contains minor, but bioactive, components such as polyphenols, tocopherols, and phytosterols, contributing to its oxidative stability, sensory qualities, and health-promoting properties. These include polyphenols, like oleuropein, hydroxytyrosol, and tyrosol, which exhibit anti-inflammatory, cardioprotective, neuroprotective, and anticancer effects. Epidemiological studies suggest an inverse relationship between olive oil intake and CVD, with EVOO-enriched MedDiet interventions showing improved lipid profiles, reduced blood pressure, and lower cardiovascular event risk. The PREDIMED study highlights the significant role of EVOO in reducing cardiometabolic risk. This review explores the impact of EVOO's chemical components within the MedDiet framework on metabolic variables influencing cardiometabolic health.
C1 [Salvo, Andrea; Tuttolomondo, Antonino] Policlin P Giaccone, Internal Med & Stroke Care Ward, Piazza Cliniche 2, I-90127 Palermo, Italy.
   [Salvo, Andrea; Tuttolomondo, Antonino] Univ Palermo, PROMISE Dept, I-90127 Palermo, Italy.
C3 University of Palermo
RP Tuttolomondo, A (corresponding author), Policlin P Giaccone, Internal Med & Stroke Care Ward, Piazza Cliniche 2, I-90127 Palermo, Italy.; Tuttolomondo, A (corresponding author), Univ Palermo, PROMISE Dept, I-90127 Palermo, Italy.
EM andrea.salvo996@gmail.com; bruno.tuttolomondo@unipa.it
OI Tuttolomondo, Antonino/0000-0001-6440-7318
CR Abdollahi S, 2024, BMC NUTR, V10, DOI 10.1186/s40795-024-00907-0
   Abrignani V, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25094942
   Al-Shudiefat AR, 2022, PHYSIOL REP, V10, DOI 10.14814/phy2.15379
   Alhazza I. M., 2007, Journal of Pharmacology and Toxicology, V2, P427
   Alkhatib A., 2018, Encyclopedia of Endocrine Diseases, V1, P148, DOI DOI 10.1016/B978-0-12-801238-3.64358-1
   Alsharif KF, 2020, IUBMB LIFE, V72, P2121, DOI 10.1002/iub.2347
   Andreadou I, 2006, J NUTR, V136, P2213, DOI 10.1093/jn/136.8.2213
   Araujo JA, 2012, FRONT PHARMACOL, V3, DOI 10.3389/fphar.2012.00119
   Arpón A, 2016, J PHYSIOL BIOCHEM, V73, P445, DOI 10.1007/s13105-017-0552-6
   Barderas Maria G, 2013, Methods Mol Biol, V1000, P1, DOI 10.1007/978-1-62703-405-0_1
   Bartimoccia S, 2022, NUTRIENTS, V14, DOI 10.3390/nu14102153
   Bayram B, 2012, REJUV RES, V15, P71, DOI 10.1089/rej.2011.1245
   Beauchamp GK, 2005, NATURE, V437, P45, DOI 10.1038/437045a
   Bendinelli B, 2011, AM J CLIN NUTR, V93, P275, DOI 10.3945/ajcn.110.000521
   Benndorf RA, 2008, CIRC RES, V103, P1037, DOI 10.1161/CIRCRESAHA.108.184036
   Bigagli E, 2017, INT IMMUNOPHARMACOL, V43, P147, DOI 10.1016/j.intimp.2016.12.012
   Bojesen A, 2006, DIABETES CARE, V29, P1591, DOI 10.2337/dc06-0145
   Boyd JH, 2016, J INNATE IMMUN, V8, P211, DOI 10.1159/000442976
   Burger D, 2012, J AM SOC HYPERTENS, V6, P85, DOI 10.1016/j.jash.2011.11.003
   Campbell NK, 2021, NAT REV IMMUNOL, V21, P411, DOI 10.1038/s41577-020-00491-x
   Cândido FG, 2018, EUR J NUTR, V57, P2445, DOI 10.1007/s00394-017-1517-9
   Carnevale R, 2018, BRIT J CLIN PHARMACO, V84, P1566, DOI 10.1111/bcp.13589
   Carnevale R, 2017, CLIN NUTR, V36, P782, DOI 10.1016/j.clnu.2016.05.016
   Casas R, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100084
   Castejón ML, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9020149
   Chaari A, 2020, INT J BIOL MACROMOL, V162, P284, DOI 10.1016/j.ijbiomac.2020.06.170
   Charles RL, 2014, P NATL ACAD SCI USA, V111, P8167, DOI 10.1073/pnas.1402965111
   Cherian P, 2003, STROKE, V34, P2132, DOI 10.1161/01.STR.0000086466.32421.F4
   Chiavarini M, 2024, FOODS, V13, DOI 10.3390/foods13162619
   Cicerale S, 2009, CHEM SENSES, V34, P333, DOI 10.1093/chemse/bjp006
   Cicero AFG, 2008, J AM COLL NUTR, V27, P314, DOI 10.1080/07315724.2008.10719705
   Cicero AFG, 2022, APPL SCI-BASEL, V12, DOI 10.3390/app121910086
   Coles B, 2002, CIRC RES, V91, P375, DOI 10.1161/01.RES.0000032114.68919.EF
   Coles B, 2002, J BIOL CHEM, V277, P5832, DOI 10.1074/jbc.M105209200
   Cooke JP, 2004, CIRCULATION, V109, P1813, DOI 10.1161/01.CIR.0000126823.07732.D5
   Cui YS, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.617314
   Cumaoglu A, 2011, ACTA BIOCHIM POL, V58, P45
   D'Agostino R, 2021, BIOMOLECULES, V11, DOI 10.3390/biom11020137
   Danesh J, 2008, PLOS MED, V5, P600, DOI 10.1371/journal.pmed.0050078
   De la Cruz JP, 2000, THROMB RES, V100, P305, DOI 10.1016/S0049-3848(00)00321-2
   de la Torre-Carbot K, 2007, ANAL CHIM ACTA, V583, P402, DOI 10.1016/j.aca.2006.10.029
   de Pablos RM, 2019, PHARMACOL RES, V143, P58, DOI 10.1016/j.phrs.2019.03.005
   Dell'Agli M, 2008, BRIT J NUTR, V99, P945, DOI 10.1017/S0007114507837470
   Dell'Agli M, 2006, J AGR FOOD CHEM, V54, P3259, DOI 10.1021/jf0529161
   Dell'Agli M, 2010, J AGR FOOD CHEM, V58, P2246, DOI 10.1021/jf9042503
   Delles C, 2010, J HYPERTENS, V28, P2316, DOI 10.1097/HJH.0b013e32833d81b7
   des Gachons CP, 2011, J NEUROSCI, V31, P999, DOI 10.1523/JNEUROSCI.1374-10.2011
   Ditano-Vázquez P, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112833
   Dollery CM, 2006, CARDIOVASC RES, V69, P625, DOI 10.1016/j.cardiores.2005.11.003
   Donat-Vargas C, 2023, EUR J CLIN NUTR, V77, P226, DOI 10.1038/s41430-022-01221-3
   Dunn S, 2008, BIOCHEM J, V409, P349, DOI 10.1042/BJ20071196
   Storniolo CE, 2014, REDOX BIOL, V2, P971, DOI 10.1016/j.redox.2014.07.001
   Estruch R, 2018, NEW ENGL J MED, V378, DOI [10.1056/NEJMoa1800389, 10.1056/NEJMoa1200303, 10.1056/nejmoa1800389]
   Fan R, 2025, NUTRIENTS, V17, DOI 10.3390/nu17030549
   Farràs M, 2013, J NUTR BIOCHEM, V24, P1334, DOI 10.1016/j.jnutbio.2012.10.008
   Feng ZH, 2017, FOOD FUNCT, V8, P3737, DOI [10.1039/c7fo00823f, 10.1039/C7FO00823F]
   Figueiredo-González M, 2019, FOOD RES INT, V116, P447, DOI 10.1016/j.foodres.2018.08.060
   Fitó M, 2007, ARCH INTERN MED, V167, P1195, DOI 10.1001/archinte.167.11.1195
   Fitó M, 2014, EUR J HEART FAIL, V16, P543, DOI 10.1002/ejhf.61
   Fki I, 2020, BIOMED RES INT-UK, V2020, DOI 10.1155/2020/1315202
   Frankel EN, 2011, J AGR FOOD CHEM, V59, P785, DOI 10.1021/jf103813t
   Fuccelli R, 2018, MOLECULES, V23, DOI 10.3390/molecules23123212
   Garcia-Serrano S, 2021, MOL NUTR FOOD RES, V65, DOI 10.1002/mnfr.202100071
   González-Correa JA, 2007, LIPIDS, V42, P921, DOI 10.1007/s11745-007-3097-6
   Hadrich F, 2015, J OLEO SCI, V64, P835, DOI 10.5650/jos.ess15026
   Halcox JPJ, 2002, CIRCULATION, V106, P653, DOI 10.1161/01.CIR.0000025404.78001.D8
   Hao JJ, 2010, J NUTR BIOCHEM, V21, P634, DOI 10.1016/j.jnutbio.2009.03.012
   Hernáez A, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201601015
   Hernáez A, 2014, ARTERIOSCL THROM VAS, V34, P2115, DOI 10.1161/ATVBAHA.114.303374
   Hidalgo M, 2014, FOOD RES INT, V64, P553, DOI 10.1016/j.foodres.2014.07.030
   Hidalgo M, 2018, PLANT FOOD HUM NUTR, V73, P1, DOI 10.1007/s11130-017-0650-1
   Hioki T, 2021, BIOMED PHARMACOTHER, V141, DOI 10.1016/j.biopha.2021.111816
   Holbrook Jonathan, 2019, F1000Res, V8, DOI 10.12688/f1000research.17023.1
   Huang CY, 2012, J APPL PHYSIOL, V112, P883, DOI 10.1152/japplphysiol.00605.2011
   Huang QX, 2021, J AM CHEM SOC, V143, P1416, DOI 10.1021/jacs.0c10836
   Huguet-Casquero A, 2020, INT J PHARMACEUT, V586, DOI 10.1016/j.ijpharm.2020.119515
   Ikonomidis I, 2023, EUR J CLIN INVEST, V53, DOI 10.1111/eci.13983
   Ilavarasi K, 2011, CHEMOSPHERE, V84, P888, DOI 10.1016/j.chemosphere.2011.06.017
   Illesca P, 2019, BIOMED PHARMACOTHER, V109, P2472, DOI 10.1016/j.biopha.2018.11.120
   Janahmadi Z, 2017, N-S ARCH PHARMACOL, V390, P245, DOI 10.1007/s00210-016-1323-6
   Janahmadi Z, 2015, CARDIOVASC TOXICOL, V15, P61, DOI 10.1007/s12012-014-9271-1
   Jin HX, 2018, INT J MOL MED, V42, P1034, DOI 10.3892/ijmm.2018.3673
   Kaneko N, 2019, INFLAMM REGEN, V39, DOI 10.1186/s41232-019-0101-5
   Kapoor D, 2005, CLIN ENDOCRINOL, V63, P239, DOI 10.1111/j.1365-2265.2005.02299.x
   Keegan Achsah D, 2021, Fac Rev, V10, P71, DOI 10.12703/r/10-71
   KEYS A, 1986, AM J EPIDEMIOL, V124, P903, DOI 10.1093/oxfordjournals.aje.a114480
   Khazrai YM, 2014, DIABETES-METAB RES, V30, P24, DOI 10.1002/dmrr.2515
   Kim YW, 2014, BLOOD, V123, P625, DOI 10.1182/blood-2013-09-512749
   Kitsati N, 2016, REDOX BIOL, V10, P233, DOI 10.1016/j.redox.2016.10.006
   Konstantinidou V, 2009, OMICS, V13, P431, DOI 10.1089/omi.2008.0085
   Lafleur MA, 2001, BIOCHEM J, V357, P107, DOI 10.1042/0264-6021:3570107
   Lahey R, 2014, CIRCULATION, V130, P1790, DOI 10.1161/CIRCULATIONAHA.114.011687
   Lan H, 2010, J CELL PHYSIOL, V224, P273, DOI 10.1002/jcp.22130
   Lee SD, 2013, NUTR METAB CARDIOVAS, V23, P566, DOI 10.1016/j.numecd.2011.11.002
   Leri M, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21041250
   Li XL, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/8673728
   Liuzzo G, 2001, Rays, V26, P221
   Loizzo MR, 2011, J FOOD BIOCHEM, V35, P381, DOI 10.1111/j.1745-4514.2010.00390.x
   Loizzo MR, 2007, PHYTOTHER RES, V21, P32, DOI 10.1002/ptr.2008
   Marrelli M, 2014, J SCI FOOD AGR, V94, P2217, DOI 10.1002/jsfa.6544
   Martin ME, 2019, J FOOD BIOCHEM, V43, DOI 10.1111/jfbc.12941
   Martín-Peláez S, 2017, EUR J NUTR, V56, P663, DOI 10.1007/s00394-015-1110-z
   Martínez-González MA, 2022, CLIN NUTR, V41, P2659, DOI 10.1016/j.clnu.2022.10.001
   McInnes KJ, 2012, DIABETES, V61, P1072, DOI 10.2337/db11-1136
   Medina-Remón A, 2015, NUTR METAB CARDIOVAS, V25, P60, DOI 10.1016/j.numecd.2014.09.001
   Mena MP, 2009, AM J CLIN NUTR, V89, P248, DOI 10.3945/ajcn.2008.26094
   Menicacci B, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18112275
   Meza-Miranda ER, 2016, EUR J NUTR, V55, P519, DOI 10.1007/s00394-015-0868-3
   Minciullo PL, 2016, ARCH IMMUNOL THER EX, V64, P111, DOI 10.1007/s00005-015-0377-3
   Monea S, 2002, J CELL PHYSIOL, V192, P160, DOI 10.1002/jcp.10126
   Moreno-Luna R, 2012, AM J HYPERTENS, V25, P1299, DOI 10.1038/ajh.2012.128
   Muñoz-Marín J, 2013, FOOD CHEM TOXICOL, V58, P295, DOI 10.1016/j.fct.2013.04.045
   Narita Y, 2009, J AGR FOOD CHEM, V57, P9218, DOI 10.1021/jf9017383
   Oi-Kano Y, 2008, J NUTR SCI VITAMINOL, V54, P363, DOI 10.3177/jnsv.54.363
   Oi-Kano Y, 2013, J NUTR BIOCHEM, V24, P887, DOI 10.1016/j.jnutbio.2012.06.003
   Parkinson L, 2014, INT J MOL SCI, V15, P12323, DOI 10.3390/ijms150712323
   Peng SJ, 2015, FOOD FUNCT, V6, P2091, DOI [10.1039/c5fo00097a, 10.1039/C5FO00097A]
   Perez-Martinez P, 2007, ATHEROSCLEROSIS, V194, pE141, DOI 10.1016/j.atherosclerosis.2006.11.033
   PETRONI A, 1995, THROMB RES, V78, P151, DOI 10.1016/0049-3848(95)00043-7
   Pirozzi C, 2016, J NUTR BIOCHEM, V30, P108, DOI 10.1016/j.jnutbio.2015.12.004
   Prugger C, 2013, ARTERIOSCL THROM VAS, V33, P659, DOI 10.1161/ATVBAHA.112.300109
   Punch E, 2022, J AM HEART ASSOC, V11, DOI 10.1161/JAHA.121.023328
   Quirós-Fernández R, 2022, NUTRIENTS, V14, DOI 10.3390/nu14091879
   Rajagopalan S, 1996, J CLIN INVEST, V98, P2572, DOI 10.1172/JCI119076
   Ren BC, 2020, J CELL MOL MED, V24, P12355, DOI 10.1111/jcmm.15725
   Renaud Serge, 1995, American Journal of Clinical Nutrition, V61, p1360S, DOI 10.1093/ajcn/61.6.1360S
   Rietjens SJ, 2007, J AGR FOOD CHEM, V55, P7609, DOI 10.1021/jf0706934
   Rigacci S, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17060843
   Rodrigo R, 2011, HYPERTENS RES, V34, P431, DOI 10.1038/hr.2010.264
   Romani A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081776
   Ruano J, 2005, J AM COLL CARDIOL, V46, P1864, DOI 10.1016/j.jacc.2005.06.078
   Rudolph V, 2010, CARDIOVASC RES, V85, P155, DOI 10.1093/cvr/cvp275
   Ruparelia N, 2017, NAT REV CARDIOL, V14, DOI [10.1038/nrcardio.2016.185, 10.1038/nrcardio.2017.33]
   Ruzzolini J, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10101577
   Ryu SJ, 2015, J AGR FOOD CHEM, V63, P2098, DOI 10.1021/jf505894b
   Salas-Salvadó J, 2011, DIABETES CARE, V34, P14, DOI 10.2337/dc10-1288
   Santangelo C, 2016, J ENDOCRINOL INVEST, V39, P1295, DOI 10.1007/s40618-016-0506-9
   Saraiva M, 2020, J EXP MED, V217, DOI 10.1084/jem.20190418
   Schwingshackl L, 2017, NUTR DIABETES, V7, DOI 10.1038/nutd.2017.12
   Scoditti E, 2014, ATHEROSCLEROSIS, V232, P17, DOI 10.1016/j.atherosclerosis.2013.10.017
   Scoditti E, 2012, ARCH BIOCHEM BIOPHYS, V527, P81, DOI 10.1016/j.abb.2012.05.003
   Serreli G, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9020478
   Shahidi S, 2024, BMC CARDIOVASC DISOR, V24, DOI 10.1186/s12872-024-04278-z
   Shan CL, 2022, POULTRY SCI, V101, DOI 10.1016/j.psj.2021.101516
   Shannon OM, 2020, J NUTR, V150, P1151, DOI 10.1093/jn/nxaa002
   Shannon OM, 2018, J GERONTOL A-BIOL, V73, P902, DOI 10.1093/gerona/gly087
   Siemiatkowski A, 2001, ARCH IMMUNOL THER EX, V49, P317
   Siervo M, 2018, P NUTR SOC, V77, P112, DOI 10.1017/S0029665118000058
   Storniolo CE, 2017, EUR J NUTR, V56, P89, DOI 10.1007/s00394-015-1060-5
   Sun WY, 2017, NEUROPHARMACOLOGY, V113, P556, DOI 10.1016/j.neuropharm.2016.11.010
   Teissier T, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11030359
   Terés S, 2008, P NATL ACAD SCI USA, V105, P13811, DOI 10.1073/pnas.0807500105
   Togna GI, 2003, J NUTR, V133, P2532, DOI 10.1093/jn/133.8.2532
   Toma I, 2012, CELL TISSUE RES, V347, P155, DOI 10.1007/s00441-011-1189-3
   Traish AM, 2009, J ANDROL, V30, P23, DOI 10.2164/jandrol.108.005751
   Tuttolomondo A, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20194716
   Valente AJ, 2014, FREE RADICAL BIO MED, V70, P117, DOI 10.1016/j.freeradbiomed.2014.02.014
   Vezza T, 2019, PHARMACOL RES, V150, DOI 10.1016/j.phrs.2019.104487
   von zur Muhlen C, 2009, J PROTEOME RES, V8, P335, DOI 10.1021/pr800615t
   Wang SS, 2022, J CELL MOL MED, V26, P5335, DOI 10.1111/jcmm.17580
   Webster JD, 2020, FRONT CELL DEV BIOL, V8, DOI 10.3389/fcell.2020.00365
   Wu L, 2017, BIOCHEMISTRY-US, V56, P5035, DOI 10.1021/acs.biochem.7b00199
   Xia M, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.1041203
   Xing CH, 2021, ACTA CIR BRAS, V36, DOI [10.1590/acb360107, 10.1590/ACB360107]
   Yang Q, 2005, MOL PHARMACOL, V68, P210, DOI 10.1124/mol.105.011692
   Yousefi Z, 2022, INT J IMMUNOPATH PH, V36, DOI 10.1177/03946320221086084
   Yu YB, 2020, EUR REV MED PHARMACO, V24, P6455, DOI 10.26355/eurrev_202006_21544
   Yubero-Serrano EM, 2020, PLOS MED, V17, DOI 10.1371/journal.pmed.1003282
   Yubero-Serrano EM, 2019, EUR J CLIN NUTR, V72, P8, DOI 10.1038/s41430-018-0304-x
   Zhang CH, 2008, BASIC RES CARDIOL, V103, P398, DOI 10.1007/s00395-008-0733-0
   Zhang JY, 2017, INT IMMUNOPHARMACOL, V48, P187, DOI 10.1016/j.intimp.2017.05.013
   Zhang XX, 2020, BIOMED RES INT, V2020, DOI 10.1155/2020/5036572
   Zhao Y, 2017, MOL CANCER, V16, DOI 10.1186/s12943-017-0648-1
   Zimmerli LU, 2008, MOL CELL PROTEOMICS, V7, P290, DOI 10.1074/mcp.M700394-MCP200
   Zrelli H, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/912431
NR 175
TC 2
Z9 2
U1 4
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD MAR 11
PY 2025
VL 15
IS 3
AR 190
DI 10.3390/metabo15030190
PG 27
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 0RB8B
UT WOS:001453998000001
PM 40137153
OA gold
DA 2025-06-11
ER

PT J
AU Omar, JS
   Jaradat, N
   Qadoumi, M
   Qadoumi, AN
AF Omar, Jamal Shaker
   Jaradat, Nidal
   Qadoumi, Mohammad
   Qadoumi, Abdel Naser
TI Regular swimming exercise improves metabolic syndrome risk factors: a
   quasi-experimental study
SO BMC SPORTS SCIENCE MEDICINE AND REHABILITATION
LA English
DT Article
DE Swimming sessions; Metabolic risk factors; Body fat percent; Palestine
ID BLOOD-PRESSURE; PHYSICAL-ACTIVITY; HYPERTENSION; INDIVIDUALS;
   DEPRESSION; RESISTANCE; ANXIETY
AB Background In the past few decades, swimming became one of the most important physical activities within the health system and is considered a practical nonpharmacological approach to managing of type 2 diabetes (T2DM), hyperlipidemia, hypertension (HTN), and obesity. The current study aimed to assess the effect of long-term swimming sessions on glycemic and lipidemic parameters, hemodynamic responses, body fat percent, and body mass index for patients with metabolic risk factors from Palestine. Methods Forty participants from both genders with T2DM and HTN (aged 52.4 +/- 5.5 yrs) agreed to participate in this quasi-experimental study and were divided into two groups. The first group included the participants who performed long-term swimming sessions and the second group served as the control. The first group exercised for 2 h, 3 times/week in 29-33 degrees C swimming pool temperature for 16 weeks. Simultaneously, the control group did not participate in any exercise and advised them to keep on with their everyday lifestyle. All the obtained metabolic syndrome risk factors data were analyzed using a two-way ANOVA analysis of variance (2*2) which was applied to determine the differences according group, time, and interaction. Results The results showed that there were statistically significant differences at p < 0.05 in the variables of Total Cholesterol (TC), High Density of Lipoprotein (HDL), Low Density of Lipoprotein (LDL), Triglycerides (TG), Blood Glucose (BG), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Body Mass Index (BMI), and body fat percent according to group, time, and interaction for the experimental group. Conclusions The findings of the current study suggested that the regular 16 weeks of swimming sessions could be considered nonpharmacological approaches in managing T2DM and HTN.
C1 [Omar, Jamal Shaker; Qadoumi, Mohammad; Qadoumi, Abdel Naser] An Najah Natl Univ, Dept Phys Educ, Nablus 00970, Palestine.
   [Jaradat, Nidal] An Najah Natl Univ, Fac Med & Hlth Sci, Dept Pharm, Nablus 00970, Palestine.
C3 An Najah National University; An Najah National University
RP Jaradat, N (corresponding author), An Najah Natl Univ, Fac Med & Hlth Sci, Dept Pharm, Nablus 00970, Palestine.
EM nidaljaradat@najah.edu
RI Jaradat, Nidal/I-3136-2016
FU An-Najah National University [ANNU-1920-So023]
FX This research was funded by An-Najah National University, grant number
   ANNU-1920-So023.
CR Abu-Rmeileh NME, 2013, BMJ OPEN, V3, DOI 10.1136/bmjopen-2013-003558
   Ahmed GM, 2011, LIFE SCI J, V8, P366
   [Anonymous], 2013, DIAB FACT SHEET
   [Anonymous], Hypertension fact Sheets
   Åsa C, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/349209
   Baynest HW, 2015, J DIABETES METAB, V6, DOI 10.4172/2155-6156.1000541
   Bennett K, 2015, DEPRESS ANXIETY, V32, P909, DOI 10.1002/da.22400
   Boeno FP, 2020, J HYPERTENS, V38, P2501, DOI 10.1097/HJH.0000000000002581
   Carek PJ, 2011, INT J PSYCHIAT MED, V41, P15, DOI 10.2190/PM.41.1.c
   Chawla Aastha, 2016, Indian J Endocrinol Metab, V20, P546, DOI 10.4103/2230-8210.183480
   Cheung BMY, 2012, CURR ATHEROSCLER REP, V14, P160, DOI 10.1007/s11883-012-0227-2
   Colberg SR, 2010, DIABETES CARE, V33, P2692, DOI [10.2337/dc10-1548, 10.2337/dc10-9990]
   de Boer IH, 2017, DIABETES CARE, V40, P1273, DOI 10.2337/dci17-0026
   Denning WM., 2012, INT J AQUAT RES ED, V6, P7, DOI 10.25035/ijare.06.01.07
   Farinha JB, 2018, J DIABETES COMPLICAT, V32, P1124, DOI 10.1016/j.jdiacomp.2018.09.008
   Ferrannini E, 2012, LANCET, V380, P601, DOI 10.1016/S0140-6736(12)60987-8
   Gappmaier E, 2006, J SPORT MED PHYS FIT, V46, P564
   Jinnouchi H., 2020, Vessel Based Imaging Techniques: Diagnosis, Treatment, and Prevention, P211, DOI [DOI 10.1007/978-3-030-25249-611, DOI 10.1007/978-3-030-25249-6_11]
   Kasprzak Z, 2014, J HUM KINET, V41, P71, DOI 10.2478/hukin-2014-0034
   Kraus WE, 2002, NEW ENGL J MED, V347, P1483, DOI 10.1056/NEJMoa020194
   Krauss RM, 2004, DIABETES CARE, V27, P1496, DOI 10.2337/diacare.27.6.1496
   Libby P, 2005, CIRCULATION, V111, P3481, DOI 10.1161/CIRCULATIONAHA.105.537878
   Malm C, 2019, SPORTS, V7, DOI 10.3390/sports7050127
   Nedic A., 2013, HRVATSKI SPORTSKOMED, V28, P33
   Nualnim N, 2012, AM J CARDIOL, V109, P1005, DOI 10.1016/j.amjcard.2011.11.029
   Nystoriak Matthew A, 2018, Front Cardiovasc Med, V5, P135, DOI 10.3389/fcvm.2018.00135
   Pedersen BK, 2019, CURR OPIN CLIN NUTR, V22, P167, DOI 10.1097/MCO.0000000000000546
   Pedersen BK, 2006, SCAND J MED SCI SPOR, V16, P3, DOI 10.1111/j.1600-0838.2006.00520.x
   Petrie JR, 2018, CAN J CARDIOL, V34, P575, DOI 10.1016/j.cjca.2017.12.005
   Punthakee Z, 2006, J CLIN ENDOCR METAB, V91, P2119, DOI 10.1210/jc.2005-2346
   Schauer IE, 2020, CONTEMP ENDOCRINOL S, P293, DOI 10.1007/978-3-030-25057-7_18
   Sideraviciute Sandrija, 2006, Medicina (Kaunas), V42, P661
   Song D, 2019, INT J NURS STUD, V93, P97, DOI 10.1016/j.ijnurstu.2019.02.019
   Stamatakis E, 2019, J AM COLL CARDIOL, V73, P2062, DOI 10.1016/j.jacc.2019.02.031
   Tanaka H, 1997, J HYPERTENS, V15, P651, DOI 10.1097/00004872-199715060-00012
   Torres-Ronda L, 2014, J HUM KINET, V44, P237, DOI 10.2478/hukin-2014-0129
   Vanhees L, 2012, EUR J PREV CARDIOL, V19, P1005, DOI 10.1177/1741826711430926
   Wegner M, 2014, CNS NEUROL DISORD-DR, V13, P1002, DOI 10.2174/1871527313666140612102841
   Yang D, 2019, ANN NUTR METAB, V74, P313, DOI 10.1159/000500110
NR 39
TC 14
Z9 15
U1 2
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2052-1847
J9 BMC SPORTS SCI MED R
JI BMC Sports Sci. Med. Rehabil.
PD MAR 8
PY 2021
VL 13
IS 1
AR 22
DI 10.1186/s13102-021-00254-8
PG 7
WC Rehabilitation; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rehabilitation; Sport Sciences
GA QT5YP
UT WOS:000626663600001
PM 33685505
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Karuga, FF
   Jaromirska, J
   Malicki, M
   Sochal, M
   Szmyd, B
   Bialasiewicz, P
   Strzelecki, D
   Gabryelska, A
AF Karuga, Filip Franciszek
   Jaromirska, Julia
   Malicki, Mikolaj
   Sochal, Marcin
   Szmyd, Bartosz
   Bialasiewicz, Piotr
   Strzelecki, Dominik
   Gabryelska, Agata
TI The role of microRNAs in pathophysiology and diagnostics of metabolic
   complications in obstructive sleep apnea patients
SO FRONTIERS IN MOLECULAR NEUROSCIENCE
LA English
DT Review
DE microRNA; OSA; obstructive sleep apnea; diabetes; metabolic syndrome;
   metabolic complications
ID POSITIVE AIRWAY PRESSURE; DIABETIC FOOT ULCERS; INTERMITTENT HYPOXIA;
   DOWN-REGULATION; INSULIN-RESISTANCE; OXIDATIVE STRESS; AMERICAN ACADEMY;
   TNF-ALPHA; SIRTUIN 1; EXPRESSION
AB Obstructive sleep apnea (OSA) is one of the most common sleep disorders, which is characterized by recurrent apneas and/or hypopneas occurring during sleep due to upper airway obstruction. Among a variety of health consequences, OSA patients are particularly susceptible to developing metabolic complications, such as metabolic syndrome and diabetes mellitus type 2. MicroRNAs (miRNAs) as epigenetic modulators are promising particles in both understanding the pathophysiology of OSA and the prediction of OSA complications. This review describes the role of miRNAs in the development of OSA-associated metabolic complications. Moreover, it summarizes the usefulness of miRNAs as biomarkers in predicting the aforementioned OSA complications.
C1 [Karuga, Filip Franciszek; Jaromirska, Julia; Malicki, Mikolaj; Sochal, Marcin; Bialasiewicz, Piotr; Gabryelska, Agata] Med Univ Lodz, Dept Sleep Med & Metab Disorders, Lodz, Poland.
   [Szmyd, Bartosz] Med Univ Lodz, Barlicki Univ Hosp, Dept Neurosurg & Neurooncol, Lodz, Poland.
   [Szmyd, Bartosz] Med Univ Lodz, Dept Pediat Oncol & Hematol, Lodz, Poland.
   [Strzelecki, Dominik] Med Univ Lodz, Dept Affect & Psychot Disorders, Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz; Medical University
   Lodz; Medical University Lodz
RP Karuga, FF; Gabryelska, A (corresponding author), Med Univ Lodz, Dept Sleep Med & Metab Disorders, Lodz, Poland.
EM filip.karuga@gmail.com; agata.gabryelska@gmail.com
RI Strzelecki, Dominik/S-9340-2016; Szmyd, Bartosz/AAM-8025-2021
OI Strzelecki, Dominik/0000-0002-8559-1078; Bialasiewicz,
   Piotr/0000-0002-8338-1747; Szmyd, Bartosz/0000-0002-4051-0887; Karuga,
   Filip/0000-0002-6551-6804
FU National Science Centre, Poland, Preludium 20 [2021/41/N/NZ5/00486]
FX The study was supported by National Science Centre, Poland, Preludium 20
   grant no. 2021/41/N/NZ5/00486 (for FFK).
CR Agrawal R, 2014, BMC GENOMICS, V15, DOI 10.1186/1471-2164-15-686
   Ahmed U, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0250773
   Akhbari M, 2019, CLIN LAB, V65, P1493, DOI 10.7754/Clin.Lab.2019.190209
   Al-Kafaji G, 2016, EXP THER MED, V12, P815, DOI 10.3892/etm.2016.3395
   Al-Rawaf HA, 2019, CLIN NUTR, V38, P2231, DOI 10.1016/j.clnu.2018.09.024
   Ali S, 2021, METABOLISM, V118, DOI 10.1016/j.metabol.2021.154727
   Arnold J, 2017, J PHARM BIOALLIED SC, V9, pS26, DOI 10.4103/jpbs.JPBS_155_17
   Arslan B, 2021, LARYNGOSCOPE INVEST, V6, P1466, DOI 10.1002/lio2.683
   Bock C, 2009, EPIGENOMICS-UK, V1, P99, DOI 10.2217/EPI.09.6
   Bonsignore MR, 2019, MULTIDISCIP RESP MED, V14, DOI 10.1186/s40248-019-0172-9
   Boutagy NE, 2016, BIOCHIMIE, V124, P11, DOI 10.1016/j.biochi.2015.06.020
   Cao Y, 2022, MEDICINE, V101, DOI 10.1097/MD.0000000000028930
   Chang AC, 2018, RETINA-J RET VIT DIS, V38, P2197, DOI 10.1097/IAE.0000000000001848
   Chen XJ, 2020, BIOCHEM CELL BIOL, V98, P277, DOI 10.1139/bcb-2019-0174
   Chen YC, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21030999
   Coughlin SR, 2004, EUR HEART J, V25, P735, DOI 10.1016/j.ehj.2004.02.021
   Cuevas A, 2014, ARCH BIOCHEM BIOPHYS, V557, P28, DOI 10.1016/j.abb.2014.04.009
   Czarnecka KH, 2019, FRONT ONCOL, V9, DOI 10.3389/fonc.2019.01372
   Dehghani M, 2020, ENDOCRINOL DIAB NUTR, V67, P454, DOI 10.1016/j.endinu.2019.09.009
   Deng J., 2019, ExRNA, DOI DOI 10.1186/S41544-019-0038-5
   Doghish AS, 2021, CAN J DIABETES, V45, P614, DOI 10.1016/j.jcjd.2020.12.005
   Dong P, 2018, BEHAV BRAIN RES, V347, P325, DOI 10.1016/j.bbr.2018.03.031
   Drager LF., 2009, J Cardiometab Syndr, V4, P89, DOI DOI 10.1111/J.1559-4572.2008.00046.X
   Drager LF, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012065
   Dutkowska A, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-84408-1
   Engin A, 2017, ADV EXP MED BIOL, V960, P1, DOI 10.1007/978-3-319-48382-5_1
   Fallahi A, 2019, DIAB MET SYND CLIN R, V13, P2463, DOI 10.1016/j.dsx.2019.06.030
   Fleming WE, 2018, NAT SCI SLEEP, V10, P159, DOI 10.2147/NSS.S164488
   Freude T, 2012, J MOL MED, V90, P1257, DOI 10.1007/s00109-012-0948-2
   Fu YQ, 2017, SLEEP BREATH, V21, P181, DOI 10.1007/s11325-016-1393-1
   Gabryelska A, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24031808
   Gabryelska A, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms232314876
   Gabryelska A, 2022, J CLIN MED, V11, DOI 10.3390/jcm11237135
   Gabryelska A, 2022, J CLIN MED, V11, DOI 10.3390/jcm11010139
   Gabryelska A, 2021, J CLIN MED, V10, DOI 10.3390/jcm10173770
   Gabryelska A, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.01035
   Gabryelska A, 2020, J CLIN SLEEP MED, V16, P1761, DOI 10.5664/jcsm.8682
   Gabryelska A, 2020, J SLEEP RES, V29, DOI 10.1111/jsr.12995
   Gabryelska A, 2020, POL ARCH INTERN MED, V130, P158, DOI 10.20452/pamw.15104
   Galicia-Garcia U, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21176275
   Gao J, 2022, BIOENGINEERED, V13, P12275, DOI 10.1080/21655979.2022.2067293
   Gaspar LS, 2022, SLEEP MED REV, V64, DOI 10.1016/j.smrv.2022.101659
   Gok O, 2019, J RES MED SCI, V24, DOI 10.4103/jrms.JRMS_921_18
   Guan CY, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.917386
   Guo CY, 2022, J IMMUNOL RES, V2022, DOI 10.1155/2022/7236647
   Guo LM, 2020, BOSNIAN J BASIC MED, V20, P372, DOI 10.17305/bjbms.2019.4410
   Han DW, 2021, J MOL HISTOL, V52, P681, DOI 10.1007/s10735-021-09996-8
   Hassani SS, 2023, LAB MED, V54, P160, DOI 10.1093/labmed/lmac082
   He ZY, 2019, J CELL PHYSIOL, V234, P4627, DOI 10.1002/jcp.27260
   Hernández-Jiménez E, 2017, EUR RESPIR J, V49, DOI 10.1183/13993003.02456-2016
   Hromadnikova I, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms231810635
   Hromadnikova I, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21072437
   Hu JZ, 2020, EXP EYE RES, V192, DOI 10.1016/j.exer.2020.107925
   Huang JH, 2021, BIOACT MATER, V6, P2841, DOI 10.1016/j.bioactmat.2021.02.007
   Huang YX, 2020, BIOMED RES INT, V2020, DOI 10.1155/2020/8159342
   Hulsmans M, 2012, J CLIN ENDOCR METAB, V97, pE1213, DOI 10.1210/jc.2012-1008
   Imamura T, 2016, J APPL PHYSIOL, V121, P670, DOI 10.1152/japplphysiol.00307.2016
   Jankauskas SS, 2021, NON-CODING RNA, V7, DOI 10.3390/ncrna7030039
   Jansen F, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-016-0367-8
   Ji L, 2021, SLEEP BREATH, V25, P331, DOI 10.1007/s11325-020-02124-y
   Kaczmarski P, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23169080
   Kapur VK, 2017, J CLIN SLEEP MED, V13, P479, DOI 10.5664/jcsm.6506
   Karuga FF, 2022, J CLIN MED, V11, DOI 10.3390/jcm11175008
   Kendzerska T, 2014, SLEEP MED REV, V18, P49, DOI 10.1016/j.smrv.2013.01.003
   Khalyfa A, 2018, INT J OBESITY, V42, P1127, DOI 10.1038/s41366-018-0099-9
   Khan MAB, 2020, J EPIDEMIOL GLOB HEA, V10, P107, DOI 10.2991/jegh.k.191028.001
   Khurana S, 2020, COMPUT BIOL CHEM, V87, DOI 10.1016/j.compbiolchem.2020.107264
   Kikuchi R, 2017, AM J RESP CELL MOL, V57, P570, DOI 10.1165/rcmb.2016-0278OC
   Kim C, 2013, FEBS LETT, V587, P3853, DOI 10.1016/j.febslet.2013.10.018
   Kim Michael, 2019, J Diabetes Clin Res, V1, P5, DOI [10.33696/diabetes.1.003, 10.18396/ktsa.2019.1.71.001]
   Koenen TB, 2011, DIABETES, V60, P517, DOI 10.2337/db10-0266
   Kong DL, 2016, CLIN INVEST MED, V39, pE161
   Kovacs B, 2011, INVEST OPHTH VIS SCI, V52, P4402, DOI 10.1167/iovs.10-6879
   Krawczyk M, 2013, CARDIOL J, V20, P345, DOI 10.5603/CJ.2013.0092
   Labarca G, 2021, SLEEP BREATH, V25, P1467, DOI 10.1007/s11325-020-02283-y
   Labarca G, 2018, CLIN RESPIR J, V12, P2361, DOI 10.1111/crj.12915
   Laemmle A, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033433
   Leung AKL, 2015, TRENDS CELL BIOL, V25, P601, DOI 10.1016/j.tcb.2015.07.005
   Li YB, 2017, MOL MED REP, V16, P2417, DOI 10.3892/mmr.2017.6874
   Lian NF, 2021, SLEEP BREATH, V25, P2241, DOI 10.1007/s11325-021-02319-x
   Lian WS, 2018, ACTA BIOCH BIOPH SIN, V50, P336, DOI 10.1093/abbs/gmy010
   Liang XY, 2020, EXP THER MED, V20, P1121, DOI 10.3892/etm.2020.8780
   Lim JH, 2010, MOL CELL, V38, P864, DOI 10.1016/j.molcel.2010.05.023
   Lin L, 2017, EUR REV MED PHARMACO, V21, P4147
   Lin X, 2015, INFLAMMATION, V38, P546, DOI 10.1007/s10753-014-9961-7
   Liu D, 2016, FRONT PSYCHIATRY, V7, DOI 10.3389/fpsyt.2016.00139
   Liu L, 2022, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.813280
   Liu X, 2020, MOL MED, V26, DOI 10.1186/s10020-020-00250-7
   Liu Y, 2014, INT J MOL SCI, V15, P10567, DOI 10.3390/ijms150610567
   Logan AG, 2001, J HYPERTENS, V19, P2271, DOI 10.1097/00004872-200112000-00022
   Lozano-Bartolomé J, 2018, J CLIN ENDOCR METAB, V103, P1447, DOI 10.1210/jc.2017-01909
   Macharia LW, 2021, BMC CANCER, V21, DOI 10.1186/s12885-021-08978-z
   Mahmood K, 2009, J CLIN SLEEP MED, V5, P215
   Malicki M, 2023, METABOLITES, V13, DOI 10.3390/metabo13010060
   Maltese G, 2018, DIABETIC MED, V35, P1494, DOI 10.1111/dme.13780
   Masutani H, 2012, J CLIN BIOCHEM NUTR, V50, P23, DOI 10.3164/jcbn.11-36SR
   Meng S, 2012, J MOL CELL CARDIOL, V53, P64, DOI 10.1016/j.yjmcc.2012.04.003
   Misra A, 2016, DIABETES TECHNOL THE, V18, P405, DOI 10.1089/dia.2016.0147
   Nakayama LF, 2021, J CLIN SLEEP MED, V17, P1947, DOI 10.5664/jcsm.9312
   Ofori JK, 2017, SCI REP-UK, V7, DOI 10.1038/srep44986
   Pai PY, 2022, SLEEP BREATH, V26, P1161, DOI 10.1007/s11325-021-02499-6
   Patil SP, 2019, J CLIN SLEEP MED, V15, P301, DOI 10.5664/jcsm.7638
   Pham LV, 2015, J THORAC DIS, V7, P1358, DOI 10.3978/j.issn.2072-1439.2015.07.28
   Phillips CL, 2011, AM J RESP CRIT CARE, V184, P355, DOI 10.1164/rccm.201102-0316OC
   Pordzik J, 2021, J CLIN MED, V10, DOI 10.3390/jcm10112371
   Pozniak T, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23073996
   Qi MX, 2020, BIOSCI BIOTECH BIOCH, V84, P1353, DOI 10.1080/09168451.2020.1750943
   Qin W, 2019, J BIOL REG HOMEOS AG, V33, P753
   Ramirez HA, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0137133
   Ramzan F, 2020, ACTA DIABETOL, V57, P203, DOI 10.1007/s00592-019-01406-6
   Rane S, 2010, CELL SIGNAL, V22, P1054, DOI 10.1016/j.cellsig.2010.02.008
   Rane S, 2009, CIRC RES, V104, P879, DOI 10.1161/CIRCRESAHA.108.193102
   Raut SK, 2016, MOL CELL BIOCHEM, V417, P191, DOI 10.1007/s11010-016-2729-7
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Rega-Kaun G, 2020, OBES SURG, V30, P391, DOI 10.1007/s11695-019-04190-y
   Ren J, 2018, CURR MED SCI, V38, P405, DOI 10.1007/s11596-018-1893-2
   Reutrakul S, 2020, DIABETES CARE, V43, P1681, DOI 10.2337/dci20-0014
   Reutrakul S, 2017, CHEST, V152, P1070, DOI 10.1016/j.chest.2017.05.009
   Rezk NA, 2016, IUBMB LIFE, V68, P452, DOI 10.1002/iub.1502
   Rovira-Llopis S, 2018, CELL PHYSIOL BIOCHEM, V50, P1005, DOI 10.1159/000494485
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Salari N, 2022, NEUROL SCI, V43, P219, DOI 10.1007/s10072-021-05765-3
   Samson SL, 2014, ENDOCRIN METAB CLIN, V43, P1, DOI 10.1016/j.ecl.2013.09.009
   Santamaria-Martos F, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-49940-1
   Santamaria-Martos F, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0213622
   Sapp RM, 2019, PHYSIOL REP, V7, DOI 10.14814/phy2.14173
   Sekar D, 2016, GENE, V582, P14, DOI 10.1016/j.gene.2016.01.039
   Shao HY, 2021, CONTRAST MEDIA MOL I, V2021, DOI 10.1155/2021/9731502
   Silvestris N, 2017, ONCOTARGET, V8, P95773, DOI 10.18632/oncotarget.21319
   Song BH, 2021, MOL MED REP, V24, DOI 10.3892/mmr.2021.12186
   Song J, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00724
   Su XF, 2021, BMC GERIATR, V21, DOI 10.1186/s12877-021-02461-x
   Sun C, 2007, CELL METAB, V6, P307, DOI 10.1016/j.cmet.2007.08.014
   Sun XJ, 2015, MOL CANCER RES, V13, P1347, DOI 10.1158/1541-7786.MCR-14-0697
   Sun XJ, 2015, CLIN ORTHOP RELAT R, V473, P907, DOI 10.1007/s11999-014-3842-0
   Swaroop JJ, 2012, INDIAN J MED RES, V135, P127, DOI 10.4103/0971-5916.93435
   Szweda N, 2016, CLIN DIABETOL, V5, P95, DOI 10.5603/DK.2016.0016
   Takahara S, 2018, BONE JOINT RES, V7, P139, DOI 10.1302/2046-3758.72.BJR-2017-0082.R1
   Trombetta IC, 2013, SLEEP, V36, P41, DOI 10.5665/sleep.2298
   Turkiewicz S, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222212536
   Wang C, 2022, J DIABETES INVEST, V13, P1396, DOI 10.1111/jdi.13793
   Wang DH, 2023, EUR J MED RES, V28, DOI 10.1186/s40001-023-01097-4
   Wang G, 2020, BIOCHEM BIOPH RES CO, V532, P308, DOI 10.1016/j.bbrc.2020.08.073
   Wang HS, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/4791059
   Wang HW, 2021, AGING-US, V13, P15240, DOI 10.18632/aging.203084
   Wang J, 2021, J NANOBIOTECHNOL, V19, DOI 10.1186/s12951-021-00942-0
   Wang L, 2020, EXP MOL PATHOL, V116, DOI 10.1016/j.yexmp.2020.104488
   Wang XL, 2021, J DIABETES RES, V2021, DOI 10.1155/2021/5597394
   Wang YY, 2015, CELL PHYSIOL BIOCHEM, V36, P179, DOI 10.1159/000374062
   Wang YT, 2013, J BIOMED SCI, V20, DOI 10.1186/1423-0127-20-72
   Wang Y, 2018, J TRANSL MED, V16, DOI 10.1186/s12967-018-1486-7
   Waters T, 2019, CLEV CLIN J MED, V86, P34, DOI 10.3949/ccjm.86.s1.06
   Weale CJ, 2021, DIAGNOSTICS, V11, DOI 10.3390/diagnostics11060949
   Weihe P, 2019, CURR OBES REP, V8, P472, DOI 10.1007/s13679-019-00357-x
   Wu X, 2018, J CELL PHYSIOL, V233, P9404, DOI 10.1002/jcp.26784
   Xie Weidong, 2013, PLoS One, V8, pe58639, DOI 10.1371/journal.pone.0058639
   Xie WD, 2013, BIOCHEM BIOPH RES CO, V430, P647, DOI 10.1016/j.bbrc.2012.11.097
   Xu P, 2017, CELL SIGNAL, V31, P96, DOI 10.1016/j.cellsig.2017.01.012
   Yan CQ, 2022, DRUG DELIV, V29, P214, DOI 10.1080/10717544.2021.2023699
   Yan ST, 2014, MOL CELL BIOCHEM, V397, P45, DOI 10.1007/s11010-014-2170-8
   Yan YR, 2021, FREE RADICAL BIO MED, V165, P401, DOI 10.1016/j.freeradbiomed.2021.01.053
   Yang XP, 2018, RESP RES, V19, DOI 10.1186/s12931-018-0894-9
   Ye PP, 2014, INT J MED SCI, V11, P17, DOI 10.7150/ijms.7329
   YOUNG T, 1993, NEW ENGL J MED, V328, P1230, DOI 10.1056/NEJM199304293281704
   Zha FF, 2019, AGING-US, V11, P3716, DOI 10.18632/aging.102011
   Zhang C, 2019, EXP THER MED, V17, P17, DOI 10.3892/etm.2018.6932
   Zhang J, 2017, J DIABETES COMPLICAT, V31, P241, DOI 10.1016/j.jdiacomp.2016.07.026
   Zhang RM, 2020, INT J MOL MED, V46, P2161, DOI 10.3892/ijmm.2020.4751
   Zhang XB, 2020, TRANSL CANCER RES, V9, P4354, DOI 10.21037/tcr-19-2913
   Zhang YN, 2017, BIOCHEM BIOPH RES CO, V492, P243, DOI 10.1016/j.bbrc.2017.08.058
   Zhao L, 2021, EXP THER MED, V21, DOI 10.3892/etm.2021.10000
   Zhao SF, 2021, ACTA DIABETOL, V58, P1251, DOI 10.1007/s00592-021-01713-x
   Zhen L, 2017, AM J TRANSL RES, V9, P2384
   Zhou B, 2012, DIABETOLOGIA, V55, P2032, DOI 10.1007/s00125-012-2539-8
   Zhou J, 2014, HORM METAB RES, V46, P201, DOI 10.1055/s-0033-1357139
   Zhou L, 2021, J RECEPT SIG TRANSD, V41, P19, DOI 10.1080/10799893.2020.1783556
NR 176
TC 3
Z9 4
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1662-5099
J9 FRONT MOL NEUROSCI
JI Front. Molec. Neurosci.
PD JUL 21
PY 2023
VL 16
AR 1208886
DI 10.3389/fnmol.2023.1208886
PG 12
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA O1ZG2
UT WOS:001041865300001
PM 37547923
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ke, ZL
   Tan, S
   Li, HY
   Jiang, SS
   Li, YP
   Chen, R
   Li, MX
AF Ke, Zunli
   Tan, Si
   Li, Haiyang
   Jiang, Shanshan
   Li, Yuping
   Chen, Rui
   Li, Mingxia
TI Tangeretin improves hepatic steatosis and oxidative stress through the
   Nrf2 pathway in high fat diet-induced nonalcoholic fatty liver disease
   mice
SO FOOD & FUNCTION
LA English
DT Article
ID INSULIN-RESISTANCE
AB Nonalcoholic liver disease (NAFLD) is a pathological condition characterized by excessive fat deposition in the liver, and NAFLD usually has a close relationship with obesity or metabolic syndrome. Currently, oxidative stress is considered as an important risk factor in the progression of NAFLD, therefore, effective amelioration of oxidative stress has emerged as a promising way to improve NAFLD. Tangeretin is a natural compound having various pharmacological activities including antioxidation and hepatoprotection. However, whether tangeretin is able to improve NAFLD through reducing hepatic oxidative stress is rarely reported. In our work, the preventive effects of tangeretin on a NAFLD mouse model induced by a high fat (HF) diet were studied. The results exhibited that tangeretin supplementation observably slowed down NAFLD progression through alleviation of metabolic indexes such as glucose tolerance, serum lipid levels and inflammatory factors, hepatic oxidative stress as well as steatosis. qRT-PCR showed that tangeretin supplementation increased the nuclear factor erythroid-2-related factor 2 (Nrf2) expression and then upregulated the expression of its downstream factors including HO-1, GCLC, NQO1 and GSTA2. Furthermore, the expression of the hepatic nucleus, Nrf2, HO-1 and GCLC, was also seen to be significantly enhanced in WB analysis. Taken together, this study implies that tangeretin might alleviate NAFLD through lowering oxidative stress in the liver by partial modulation of the Nrf2 pathway. Our study provided theoretical support that tangeretin could be used as a dietary therapy for obesity related-NAFLD or related metabolic syndrome.
C1 [Ke, Zunli; Li, Haiyang; Jiang, Shanshan; Li, Yuping; Chen, Rui] Guizhou Univ Tradit Chinese Med, Basic Med Sch, Guiyang 550025, Guizhou, Peoples R China.
   [Tan, Si] Yangtze Normal Univ, Sch Adv Agr & Bioengn, Chongqing 408100, Peoples R China.
   [Li, Mingxia] Third Mil Med Univ, Southwest Hosp, Dept Stem Cell & Regenerat Med, Army Med Univ, Chongqing 400038, Peoples R China.
C3 Guizhou University of Traditional Chinese Medicine; Yangtze Normal
   University; Army Medical University
RP Li, MX (corresponding author), Third Mil Med Univ, Southwest Hosp, Dept Stem Cell & Regenerat Med, Army Med Univ, Chongqing 400038, Peoples R China.
EM WYLHLMX@163.com
RI Jiang, Shanshan/O-8265-2019; Li, Haiyang/HJZ-3793-2023
FU National Natural Science Foundation of China [82060797]; Guizhou
   Academic Talents and Innovative Exploration Projects [[2018]5766-17];
   Guizhou Province Department of Education Youth Science and Technology
   Talent Growth Project [[2021] 195]; Science and Technology Foundation of
   Guizhou Province [Qian kehejichu-ZK [2021] yiban 400]; Doctoral Fund of
   Guizhou University of Traditional Chinese Medicine [[2019] 28]; Program
   of Innovative Scientific and Technological Talent Team of Guizhou
   Province [2020-5010]
FX This work was supported by the National Natural Science Foundation of
   China (Grant No. 82060797), the Guizhou Academic Talents and Innovative
   Exploration Projects (Qian kehe platform talents [2018]5766-17), the
   Guizhou Province Department of Education Youth Science and Technology
   Talent Growth Project (Guizhou Education KY word [2021] 195), the
   Science and Technology Foundation of Guizhou Province (No. Qian
   kehejichu-ZK [2021] yiban 400), the Doctoral Fund of Guizhou University
   of Traditional Chinese Medicine ([2019] 28) and the Program of
   Innovative Scientific and Technological Talent Team of Guizhou Province
   (2020-5010).
CR Arroyave-Ospina JC, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10020174
   Ashrafizadeh M., 2020, J BASIC CLIN PHYSIOL, V1
   Chambel SS, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/597134
   Chowdhry S, 2010, FREE RADICAL BIO MED, V48, P357, DOI 10.1016/j.freeradbiomed.2009.11.007
   Feng KL, 2020, J AGR FOOD CHEM, V68, P6142, DOI 10.1021/acs.jafc.0c01778
   Fu MQ, 2017, FOOD CHEM, V230, P649, DOI 10.1016/j.foodchem.2017.03.098
   Huang T, 2020, INTERN MED J, V50, P1038, DOI 10.1111/imj.14709
   Kahn SE, 2006, NATURE, V444, P840, DOI 10.1038/nature05482
   Ke ZL, 2020, J NUTR BIOCHEM, V83, DOI 10.1016/j.jnutbio.2020.108426
   Ke ZL, 2018, J FUNCT FOODS, V47, P28, DOI 10.1016/j.jff.2018.05.032
   Kim MS, 2012, MOL CELL ENDOCRINOL, V358, P127, DOI 10.1016/j.mce.2012.03.013
   Lara-Castro C, 2008, ENDOCRIN METAB CLIN, V37, P841, DOI 10.1016/j.ecl.2008.09.002
   Lee YY, 2016, J NEUROIMMUNE PHARM, V11, P294, DOI 10.1007/s11481-016-9657-x
   Liang FQ, 2018, J AGR FOOD CHEM, V66, P6317, DOI 10.1021/acs.jafc.8b01875
   Musso G, 2016, NAT REV DRUG DISCOV, V15, P249, DOI 10.1038/nrd.2015.3
   Nagle CA, 2009, J LIPID RES, V50, pS74, DOI 10.1194/jlr.R800053-JLR200
   Omar HA, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0151649
   Shaunak M, 2021, ARCH DIS CHILD, V106, P3, DOI 10.1136/archdischild-2019-318063
   Smolková K, 2020, ANTIOXID REDOX SIGN, V33, P966, DOI 10.1089/ars.2020.8024
   Tung YC, 2018, FOOD FUNCT, V9, P3363, DOI [10.1039/c7fo02066j, 10.1039/C7FO02066J]
   Yang JS, 2017, INFLAMMOPHARMACOLOGY, V25, P471, DOI 10.1007/s10787-017-0348-x
   Younossi ZM, 2018, LIVER TRANSPLANT, V24, P166, DOI 10.1002/lt.25003
NR 22
TC 15
Z9 16
U1 7
U2 59
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD MAR 7
PY 2022
VL 13
IS 5
BP 2782
EP 2790
DI 10.1039/d1fo02989d
EA JAN 2022
PG 9
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA ZO1BY
UT WOS:000755897700001
PM 35171164
DA 2025-06-11
ER

PT J
AU Razani, B
   Chakravarthy, MV
   Semenkovich, CF
AF Razani, Babak
   Chakravarthy, Manu V.
   Semenkovich, Clay F.
TI Insulin Resistance and Atherosclerosis
SO ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
LA English
DT Review
ID CORONARY-HEART-DISEASE; NF-KAPPA-B; OXIDATIVE DNA-DAMAGE; CARDIOVASCULAR
   RISK-FACTORS; JUN NH2-TERMINAL KINASE; NECROSIS-FACTOR-ALPHA; METABOLIC
   SYNDROME; MYOCARDIAL-INFARCTION; NITRIC-OXIDE; ENDOTHELIAL DYSFUNCTION
AB Insulin resistance characterizes type 2 diabetes and the metabolic syndrome, disorders associated with an increased risk of death due to macrovascular disease. In the past few decades, research from both the basic science and clinical arenas has enabled evidence-based use of therapeutic modalities such as statins and angiotensin-converting enzyme inhibitors to reduce cardiovascular (CV) mortality in insulin-resistant patients. Recently, promising drugs such as the thiazolidinediones have come under scrutiny for possible deleterious CV effects. Ongoing research has broadened our understanding of the pathophysiology of atherosclerosis, implicating detrimental effects of inflammation and the cellular stress response on the vasculature. In this review, we address current thinking that is shaping our molecular understanding of insulin resistance and atherosclerosis.
C1 [Chakravarthy, Manu V.; Semenkovich, Clay F.] Washington Univ, Sch Med, Dept Med, Div Endocrinol Metab & Lipid Res, St Louis, MO 63110 USA.
   [Razani, Babak] Washington Univ, Sch Med, Dept Med, Div Cardiovasc, St Louis, MO 63110 USA.
C3 Washington University (WUSTL); Washington University (WUSTL)
RP Semenkovich, CF (corresponding author), Washington Univ, Sch Med, Dept Med, Div Endocrinol Metab & Lipid Res, Campus Box 8127,660 S Enclid Ave, St Louis, MO 63110 USA.
EM csemenko@wustl.edu
RI Segura-Aguilar, Juan/H-8839-2013; Chakravarthy, Manu/AAD-7553-2021
OI Semenkovich, Clay/0000-0003-1163-1871; Razani, Babak/0000-0002-7172-9240
FU National Institutes of Health [HL083762, DK076729]
FX This work was supported by Grants HL083762 and DK076729 from the
   National Institutes of Health.
CR Adiels M, 2005, ARTERIOSCL THROM VAS, V25, P1697, DOI 10.1161/01.ATV.0000172689.53992.25
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alexander CM, 2003, DIABETES, V52, P1210, DOI 10.2337/diabetes.52.5.1210
   AUSTIN MA, 1990, CIRCULATION, V82, P495, DOI 10.1161/01.CIR.82.2.495
   Baldwin AS, 1996, ANNU REV IMMUNOL, V14, P649, DOI 10.1146/annurev.immunol.14.1.649
   Ballinger SW, 2002, CIRCULATION, V106, P544, DOI 10.1161/01.CIR.0000023921.93743.89
   Bansal S, 2007, JAMA-J AM MED ASSOC, V298, P309, DOI 10.1001/jama.298.3.309
   BAR RS, 1978, NEW ENGL J MED, V298, P1164, DOI 10.1056/NEJM197805252982103
   Baumgartl J, 2006, CELL METAB, V3, P247, DOI 10.1016/j.cmet.2006.02.010
   Bernal-Mizrachi C, 2005, NATURE, V435, P502, DOI 10.1038/nature03527
   Björnheden T, 1999, ARTERIOSCL THROM VAS, V19, P870, DOI 10.1161/01.ATV.19.4.870
   Botto N, 2002, CORONARY ARTERY DIS, V13, P269, DOI 10.1097/00019501-200208000-00004
   Botto N, 2001, MUTAT RES-GEN TOX EN, V493, P23, DOI 10.1016/S1383-5718(01)00162-0
   Bouhlel MA, 2007, CELL METAB, V6, P137, DOI 10.1016/j.cmet.2007.06.010
   Brownlee M, 2005, DIABETES, V54, P1615, DOI 10.2337/diabetes.54.6.1615
   Capell BC, 2007, CIRC RES, V101, P13, DOI 10.1161/CIRCRESAHA.107.153692
   CASALONE R, 1991, HUM GENET, V87, P139, DOI 10.1007/BF00204169
   Chang JD, 2007, P NATL ACAD SCI USA, V104, P8077, DOI 10.1073/pnas.0702663104
   Christiansen T, 2005, INT J OBESITY, V29, P146, DOI 10.1038/sj.ijo.0802839
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Collins R, 2004, LANCET, V363, P757
   CORNWELL D G, 1981, Progress in Lipid Research, V20, P365, DOI 10.1016/0163-7827(81)90069-2
   DEBUSK FL, 1972, J PEDIATR-US, V80, P697, DOI 10.1016/S0022-3476(72)80229-4
   Dormandy JA, 2005, LANCET, V366, P1279, DOI 10.1016/S0140-6736(05)67528-9
   Dröge W, 2002, PHYSIOL REV, V82, P47, DOI 10.1152/physrev.00018.2001
   Du XL, 2006, J CLIN INVEST, V116, P1071, DOI 10.1172/JCI23354
   Echtay KS, 2007, FREE RADICAL BIO MED, V43, P1351, DOI 10.1016/j.freeradbiomed.2007.08.011
   Eriksson M, 2003, NATURE, V423, P293, DOI 10.1038/nature01629
   Esposito K, 2003, JAMA-J AM MED ASSOC, V289, P1799, DOI 10.1001/jama.289.14.1799
   FALTA W, 1924, KLIN WCHNSCHR, V3, P1315
   Festa A, 2002, DIABETES, V51, P1131, DOI 10.2337/diabetes.51.4.1131
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Fong LG, 2006, SCIENCE, V311, P1621, DOI 10.1126/science.1124875
   Furuhashi M, 2007, NATURE, V447, P959, DOI 10.1038/nature05844
   Geissmann F, 2003, IMMUNITY, V19, P71, DOI 10.1016/S1074-7613(03)00174-2
   Ginsberg HN, 2006, J CLIN ENDOCR METAB, V91, P383, DOI 10.1210/jc.2005-2084
   GOLAY A, 1987, J CLIN ENDOCR METAB, V65, P512, DOI 10.1210/jcem-65-3-512
   Gordon S, 2005, NAT REV IMMUNOL, V5, P953, DOI 10.1038/nri1733
   Gordon S, 2003, NAT REV IMMUNOL, V3, P23, DOI 10.1038/nri978
   Gray MD, 1997, NAT GENET, V17, P100, DOI 10.1038/ng0997-100
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Gual P, 2003, DIABETOLOGIA, V46, P1532, DOI 10.1007/s00125-003-1223-4
   Haffner SM, 1998, NEW ENGL J MED, V339, P229, DOI 10.1056/NEJM199807233390404
   Han S, 2006, CELL METAB, V3, P257, DOI 10.1016/j.cmet.2006.02.008
   Hartge MM, 2006, ENDOCRIN METAB CLIN, V35, P551, DOI 10.1016/j.ecl.2006.06.006
   Hevener AL, 2007, J CLIN INVEST, V117, P1658, DOI 10.1172/JCI31561
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   HOTAMISLIGIL GS, 1995, J CLIN INVEST, V95, P2409, DOI 10.1172/JCI117936
   Hsueh WA, 2003, AM J CARDIOL, V92, p10J, DOI 10.1016/S0002-9149(03)00611-8
   Hunt KJ, 2004, CIRCULATION, V110, P1251, DOI 10.1161/01.CIR.0000140762.04598.F9
   Jiang ZY, 1999, J CLIN INVEST, V104, P447, DOI 10.1172/JCI5971
   Kanda H, 2006, J CLIN INVEST, V116, P1494, DOI 10.1172/JCI26498
   KANNEL WB, 1979, CIRCULATION, V59, P8, DOI 10.1161/01.CIR.59.1.8
   Kanters E, 2004, BLOOD, V103, P934, DOI 10.1182/blood-2003-05-1450
   Kanters E, 2003, J CLIN INVEST, V112, P1176, DOI 10.1172/JCI18580
   Karin M, 1999, J BIOL CHEM, V274, P27339, DOI 10.1074/jbc.274.39.27339
   Kempe S, 2005, NUCLEIC ACIDS RES, V33, P5308, DOI 10.1093/nar/gki836
   KLEIN PD, 1954, J BIOL CHEM, V211, P103
   Kyriakis JM, 2001, PHYSIOL REV, V81, P807, DOI 10.1152/physrev.2001.81.2.807
   Lago RM, 2007, LANCET, V370, P1129, DOI 10.1016/S0140-6736(07)61514-1
   Lau DCW, 2005, AM J PHYSIOL-HEART C, V288, pH2031, DOI 10.1152/ajpheart.01058.2004
   LEHMANN JM, 1995, J BIOL CHEM, V270, P12953, DOI 10.1074/jbc.270.22.12953
   Levin M, 2003, ARTERIOSCL THROM VAS, V23, P1801, DOI 10.1161/01.ATV.0000092872.54026.8D
   Levinson Paul D, 2003, Med Health R I, V86, P101
   Lincoff AM, 2007, JAMA-J AM MED ASSOC, V298, P1180, DOI 10.1001/jama.298.10.1180
   Lindholm LH, 2002, LANCET, V359, P1004, DOI 10.1016/S0140-6736(02)08090-X
   Liu YY, 2006, J CELL SCI, V119, P4644, DOI 10.1242/jcs.03263
   López-Lluch G, 2006, P NATL ACAD SCI USA, V103, P1768, DOI 10.1073/pnas.0510452103
   Lumeng CN, 2007, J CLIN INVEST, V117, P175, DOI 10.1172/JCI29881
   Mahmoudi M, 2006, CARDIOVASC RES, V71, P259, DOI 10.1016/j.cardiores.2006.03.002
   Manju K, 2006, J CELL SCI, V119, P2704, DOI 10.1242/jcs.03009
   Manning AM, 2003, NAT REV DRUG DISCOV, V2, P554, DOI 10.1038/nrd1132
   Martinet W, 2002, CIRCULATION, V106, P927, DOI 10.1161/01.CIR.0000026393.47805.21
   Martinet W, 2001, CIRC RES, V88, P733, DOI 10.1161/hh0701.088684
   Mason PA, 2003, NUCLEIC ACIDS RES, V31, P1052, DOI 10.1093/nar/gkg167
   Massip L, 2006, EXP GERONTOL, V41, P157, DOI 10.1016/j.exger.2005.10.011
   Matturri L, 2001, ATHEROSCLEROSIS, V154, P755, DOI 10.1016/S0021-9150(00)00488-3
   MCGARRY JD, 1992, SCIENCE, V258, P766, DOI 10.1126/science.1439783
   Metzler B, 2000, AM J PATHOL, V156, P1875, DOI 10.1016/S0002-9440(10)65061-4
   Montagnani M, 2002, MOL ENDOCRINOL, V16, P1931, DOI 10.1210/me.2002-0074
   Montagnani M, 2002, J BIOL CHEM, V277, P1794, DOI 10.1074/jbc.M103728200
   MORRELL D, 1986, JNCI-J NATL CANCER I, V77, P89
   Ninomiya JK, 2004, CIRCULATION, V109, P42, DOI 10.1161/01.CIR.0000108926.04022.0C
   Nishio H, 2001, HISTOCHEM J, V33, P167, DOI 10.1023/A:1017952310800
   Nisoli E, 2005, SCIENCE, V310, P314, DOI 10.1126/science.1117728
   Nissen SE, 2007, NEW ENGL J MED, V356, P2457, DOI 10.1056/NEJMoa072761
   Nordestgaard BG, 2007, JAMA-J AM MED ASSOC, V298, P299, DOI 10.1001/jama.298.3.299
   Odegaard JI, 2007, NATURE, V447, P1116, DOI 10.1038/nature05894
   PEDERSEN TR, 1994, LANCET, V344, P1383
   Perticone F, 2001, DIABETES, V50, P159, DOI 10.2337/diabetes.50.1.159
   PFEFFER MA, 1992, NEW ENGL J MED, V327, P669, DOI 10.1056/NEJM199209033271001
   Rashid S, 2003, CLIN BIOCHEM, V36, P421, DOI 10.1016/S0009-9120(03)00078-X
   Ray KK, 2005, J AM COLL CARDIOL, V46, P1425, DOI 10.1016/j.jacc.2005.05.086
   Ricci R, 2004, SCIENCE, V306, P1558, DOI 10.1126/science.1101909
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Roytblat L, 2000, OBES RES, V8, P673, DOI 10.1038/oby.2000.86
   SANTERRE RF, 1974, EXP MOL PATHOL, V20, P397, DOI 10.1016/0014-4800(74)90069-0
   Sattar N, 2004, CIRCULATION, V110, P2687, DOI 10.1161/01.CIR.0000145660.60487.94
   Sattar N, 2003, CIRCULATION, V108, P414, DOI 10.1161/01.CIR.0000080897.52664.94
   SAVITSKY K, 1995, SCIENCE, V268, P1749, DOI 10.1126/science.7792600
   SCHALCH DS, 1970, NEW ENGL J MED, V282, P1396, DOI 10.1056/NEJM197006182822503
   SCHERRER U, 1994, J CLIN INVEST, V94, P2511, DOI 10.1172/JCI117621
   Schneider JG, 2006, CELL METAB, V4, P377, DOI 10.1016/j.cmet.2006.10.002
   Schreyer SA, 1996, J BIOL CHEM, V271, P26174, DOI 10.1074/jbc.271.42.26174
   Schwartz EA, 2006, ENDOCRIN METAB CLIN, V35, P525, DOI 10.1016/j.ecl.2006.06.005
   SHEPHERD J, 1995, NEW ENGL J MED, V333, P1301, DOI 10.1056/NEJM199511163332001
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   SPARKS JD, 1994, BBA-LIPID LIPID MET, V1215, P9, DOI 10.1016/0005-2760(94)90088-4
   STAMLER J, 1993, DIABETES CARE, V16, P434, DOI 10.2337/diacare.16.2.434
   Steinberg HO, 1997, J CLIN INVEST, V100, P1230, DOI 10.1172/JCI119636
   Su Y, 2000, ANN INTERN MED, V133, P770, DOI 10.7326/0003-4819-133-10-200011210-00009
   Sumara G, 2005, CELL MOL LIFE SCI, V62, P2487, DOI 10.1007/s00018-005-5253-6
   Szapary PO, 2004, AM HEART J, V148, P211, DOI 10.1016/j.ahj.2004.03.037
   Takeda K, 2001, ARTERIOSCL THROM VAS, V21, P868, DOI 10.1161/01.ATV.21.5.868
   Thurberg BL, 1998, CURR OPIN LIPIDOL, V9, P387, DOI 10.1097/00041433-199810000-00002
   Vaccaro O, 2004, ARCH INTERN MED, V164, P1438, DOI 10.1001/archinte.164.13.1438
   Ventura JJ, 2003, MOL CELL BIOL, V23, P2871, DOI 10.1128/MCB.23.8.2871-2882.2003
   Weisberg SP, 2006, J CLIN INVEST, V116, P115, DOI 10.1172/JCI24335
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Williams SB, 1996, J AM COLL CARDIOL, V27, P567, DOI 10.1016/0735-1097(95)00522-6
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yamada K, 1999, DIABETES CARE, V22, P2094, DOI 10.2337/diacare.22.12.2094
   Yki-Jarvinen H, 2004, NEW ENGL J MED, V351, P1106, DOI 10.1056/NEJMra041001
   YUSUF S, 1992, LANCET, V340, P1173, DOI 10.1016/0140-6736(92)92889-N
   Yusuf S, 2000, NEW ENGL J MED, V342, P145
   Zeng GY, 2000, CIRCULATION, V101, P1539, DOI 10.1161/01.CIR.101.13.1539
NR 126
TC 95
Z9 104
U1 0
U2 4
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0889-8529
EI 1558-4410
J9 ENDOCRIN METAB CLIN
JI Endocrinol. Metabol. Clin. North Amer.
PD SEP
PY 2008
VL 37
IS 3
BP 603
EP +
DI 10.1016/j.ecl.2008.05.001
PG 20
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 357WJ
UT WOS:000259877600005
PM 18775354
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Le, MH
   Le, DM
   Baez, TC
   Dang, HS
   Nguyen, VH
   Lee, KS
   Stave, CD
   Ito, T
   Wu, YK
   Yeo, YH
   Ji, FP
   Cheung, R
   Nguyen, MH
AF Le, Michael H.
   Le, David M.
   Baez, Thomas C.
   Dang, Hansen
   Nguyen, Vy H.
   Lee, Keeseok
   Stave, Christopher D.
   Ito, Takanori
   Wu, Yuankai
   Yeo, Yee Hui
   Ji, Fanpu
   Cheung, Ramsey
   Nguyen, Mindie H.
TI Global incidence of adverse clinical events in nonalcoholic fatty liver
   disease: A systematic review and meta-analysis
SO CLINICAL AND MOLECULAR HEPATOLOGY
LA English
DT Article
DE NAFLD; Cirrhosis; Meta-analysis; Epidemiology
ID NAFLD; PREVALENCE; MORTALITY; OUTCOMES
AB Background/Aims: Nonalcoholic fatty liver disease (NAFLD) is associated with a multitude of adverse outcomes. We aimed to estimate the pooled incidence of NAFLD-related adverse events. Methods: We performed a systematic review and meta-analysis of cohort studies of adults with NAFLD to evaluate the pooled incidence of adverse events. Results: 19,406 articles were screened, 409 full-text articles reviewed, and 79 eligible studies (1,377,466 persons) were included. Mean age was 51.47 years and body mass index 28.90 kg/m( 2) . Baseline comorbidities included metabolic syndrome (41.73%), cardiovascular disease (CVD) (16.83%), cirrhosis (21.97%), and nonalcoholic steatohepatitis (NASH) (58.85%). Incidence rate per 1,000 person-years for mortality included: all-cause (14.6), CVD-related (4.53), non-liver cancer-related (4.53), and liver-related (3.10). Incidence for liver-related events included overall (24.3), fibrosis progression (49.0), cirrhosis (10.9), liver transplant (12.0), and hepatocellular carcinoma (HCC) (3.39). Incidence for non-liver events included metabolic syndrome (25.4), hypertension (25.8), dyslipidemia (26.4), diabetes (19.0), CVD (24.77), renal impairment (30.3), depression/anxiety (29.1), and non-liver cancer (10.5). Biopsy-proven NASH had higher incidence of HCC ( P =0.043) compared to non-NASH. Higher rates of CVD and mortality were observed in North America and Europe, hypertension and non-liver cancer in North America, and HCC in Western Pacific/Southeast Asia ( P <0.05). No significant differences were observed by sex. Time -period analyses showed decreasing rates of cardiovascular and non-liver cancer mortality and increasing rates of decompensated cirrhosis ( P <0.05). Conclusions: People with NAFLD have high incidence of liver and non-liver adverse clinical events, varying by NASH, geographic region, and time-period, but not sex.
C1 [Le, Michael H.] Univ Vermont, Larner Coll Med, Burlington, VT USA.
   [Le, Michael H.; Le, David M.; Dang, Hansen; Nguyen, Vy H.; Cheung, Ramsey; Nguyen, Mindie H.] Stanford Univ, Div Gastroenterol & Hepatol, Med Ctr, 780 Welch Rd, Palo Alto, CA 94304 USA.
   [Le, David M.; Baez, Thomas C.] Burrell Coll Osteopath Med, Las Cruces, NM USA.
   [Dang, Hansen] Univ Iowa, Carver Coll Med, Iowa City, IA USA.
   [Nguyen, Vy H.] Harvard Med Sch, Boston, MA USA.
   [Lee, Keeseok] Stanford Univ, Stanford, CA USA.
   [Stave, Christopher D.] Stanford Univ, Lane Lib, Sch Med, Stanford, CA USA.
   [Ito, Takanori] Nagoya Univ, Dept Gastroenterol & Hepatol, Grad Sch Med, Nagoya, Japan.
   [Wu, Yuankai] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Infect Dis, Guangzhou, Peoples R China.
   [Yeo, Yee Hui] Cedars Sinai Med Ctr, Karsh Div Gastroenterol & Hepatol, Los Angeles, CA USA.
   [Ji, Fanpu] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Infect Dis, Xian, Shaanxi, Peoples R China.
   [Ji, Fanpu] Xi An Jiao Tong Univ, Natl & Local Joint Engn Res Ctr Biodiag & Biothera, Affiliated Hosp 2, Xian, Shaanxi, Peoples R China.
   [Cheung, Ramsey] Palo Alto Vet Affairs Med Ctr, Div Gastroenterol & Hepatol, Palo Alto, CA USA.
   [Nguyen, Mindie H.] Stanford Univ, Dept Epidemiol & Populat Hlth, Med Ctr, Palo Alto, CA USA.
C3 University of Vermont; Stanford University; University of Iowa; Harvard
   University; Harvard Medical School; Stanford University; Stanford
   University; Nagoya University; Sun Yat Sen University; Cedars Sinai
   Medical Center; Xi'an Jiaotong University; Xi'an Jiaotong University;
   Stanford University
RP Nguyen, MH (corresponding author), Stanford Univ, Div Gastroenterol & Hepatol, Med Ctr, 780 Welch Rd, Palo Alto, CA 94304 USA.
EM mindiehn@stanford.edu
RI Wu, Yuankai/Z-3147-2019; Yeo, Y/GWV-3316-2022; Nguyen,
   Huong/AAI-6249-2020; Huy, Nguyen Tien/B-2573-2010
OI Le, Michael/0000-0001-5051-3160; Nguyen, Vy/0000-0002-9888-8321
FX Conflicts of Interest MHN: Research funding: Pfizer, Enanta, Astra
   Zeneca, Delfi Technologies, GSK, Gilead, CurveBio, Exact Sciences, Helio
   Health, Glycotest, Vir Biotech; Consulting: Exelixis, Gilead,
   In-tercept, GSK, Exact Science.
CR Allen AM, 2018, HEPATOLOGY, V67, P1726, DOI 10.1002/hep.29546
   [Anonymous], 2022, World obesity atlas 2022
   Bianco C, 2021, J HEPATOL, V74, P775, DOI 10.1016/j.jhep.2020.11.024
   Byrne CD, 2020, J HEPATOL, V72, P785, DOI 10.1016/j.jhep.2020.01.013
   Byrne CD, 2015, J HEPATOL, V62, pS47, DOI 10.1016/j.jhep.2014.12.012
   Dyson J, 2014, J HEPATOL, V60, P110, DOI 10.1016/j.jhep.2013.08.011
   Ekstedt M, 2015, HEPATOLOGY, V61, P1547, DOI 10.1002/hep.27368
   Golabi P, 2018, MEDICINE, V97, DOI [10.1097/MD.0000000000010214, 10.1097/md.0000000000010214]
   Gonzalez-Chagolla A, 2022, LANCET REG HEALTH-AM, V7, DOI 10.1016/j.lana.2021.100151
   Le MH, 2022, CLIN GASTROENTEROL H, V20, P2809, DOI 10.1016/j.cgh.2021.12.002
   Le MH, 2022, CLIN MOL HEPATOL, V28, P841, DOI 10.3350/cmh.2022.0239
   Le MH, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0173499
   Lee BP, 2024, HEPATOLOGY, V79, P666, DOI 10.1097/HEP.0000000000000604
   Mantovani A, 2021, LANCET GASTROENTEROL, V6, P903, DOI 10.1016/S2468-1253(21)00308-3
   Mantovani A, 2022, GUT, V71, P778, DOI 10.1136/gutjnl-2021-324191
   Mishra Saurabh, 2022, Euroasian J Hepatogastroenterol, V12, pS26, DOI 10.5005/jp-journals-10018-1364
   Nguyen VH, 2021, CLIN GASTROENTEROL H, V19, P2172, DOI 10.1016/j.cgh.2021.05.029
   Ong JP, 2008, J HEPATOL, V49, P608, DOI 10.1016/j.jhep.2008.06.018
   Page MJ, 2021, BMJ-BRIT MED J, V372, DOI [10.1136/bmj.n71, 10.1136/bmj.n160]
   Paik JM, 2020, HEPATOLOGY, V72, P1605, DOI 10.1002/hep.31173
   Pais R, 2017, ALIMENT PHARM THER, V46, P856, DOI 10.1111/apt.14261
   Rinella ME, 2023, HEPATOLOGY, V77, P1797, DOI 10.1097/HEP.0000000000000323
   Rinella ME, 2023, J HEPATOL, V79, P1542, DOI 10.1016/j.jhep.2023.06.003
   Roderburg C, 2023, EUR J MED RES, V28, DOI 10.1186/s40001-023-01114-6
   Sanyal AJ, 2021, NEW ENGL J MED, V385, P1559, DOI 10.1056/NEJMoa2029349
   Song SJ, 2024, J HEPATOL, V80, pe54, DOI 10.1016/j.jhep.2023.07.021
   Targher G, 2021, LANCET GASTROENTEROL, V6, pS78, DOI 10.1016/S2468-1253(21)00020-0
   Taylor RS, 2020, GASTROENTEROLOGY, V158, P1611, DOI 10.1053/j.gastro.2020.01.043
   Xiao JL, 2023, J CLIN EXP HEPATOL, V13, P656, DOI 10.1016/j.jceh.2022.11.006
   Yip TCF, 2022, J HEPATOL, V76, P726, DOI 10.1016/j.jhep.2021.09.024
   Younossi Z, 2019, CLIN GASTROENTEROL H, V17, P748, DOI 10.1016/j.cgh.2018.05.057
   Younossi ZM, 2023, HEPATOLOGY, V77, P1335, DOI 10.1097/HEP.0000000000000004
   Younossi ZM, 2021, CLIN GASTROENTEROL H, V19, P580, DOI 10.1016/j.cgh.2020.05.064
   Younossi ZM, 2020, DIABETES CARE, V43, P283, DOI 10.2337/dc19-1113
   Younossi ZM, 2018, HEPATOLOGY, V68, P2405, DOI 10.1002/hep.30125
   Younossi ZM, 2016, HEPATOLOGY, V64, P1577, DOI 10.1002/hep.28785
NR 36
TC 27
Z9 28
U1 20
U2 26
PU KOREAN ASSOC STUDY LIVER
PI SEOUL
PA RM A1210, 53 MAPO-DAERO, MAPOTRAPALACE, DOWHA-DONG, MAPO-GU, SEOUL,
   04158, SOUTH KOREA
SN 2287-2728
EI 2287-285X
J9 CLIN MOL HEPATOL
JI Clin. Mol. Hepatol.
PD APR
PY 2024
VL 30
IS 2
DI 10.3350/cmh.2023.0485
PG 13
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA WP6P0
UT WOS:001256119500003
PM 38281814
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Ghorbani, Y
   Schwenger, KJP
   Sharma, D
   Jung, H
   Yadav, J
   Xu, W
   Lou, W
   Poutanen, S
   Hota, SS
   Comelli, EM
   Philpott, D
   Jackson, TD
   Okrainec, A
   Gaisano, HY
   Allard, JP
AF Ghorbani, Yasaman
   Schwenger, Katherine J. P.
   Sharma, Divya
   Jung, Hyejung
   Yadav, Jitender
   Xu, Wei
   Lou, Wendy
   Poutanen, Susan
   Hota, Susy S.
   Comelli, Elena M.
   Philpott, Dana
   Jackson, Timothy D.
   Okrainec, Allan
   Gaisano, Herbert Y.
   Allard, Johane P.
TI Effect of faecal microbial transplant via colonoscopy in patients with
   severe obesity and insulin resistance: A randomized double-blind,
   placebo-controlled Phase 2 trial
SO DIABETES OBESITY & METABOLISM
LA English
DT Article
DE colonoscopy; faecal microbiota transplant; insulin resistance;
   intestinal microbiome; metabolic syndrome; obesity
ID METABOLIC SYNDROME; INTESTINAL MICROBIOTA; KYNURENINE PATHWAY;
   SENSITIVITY; MODEL
AB Aim To assess the effects of faecal microbial transplant (FMT) from lean people to subjects with obesity via colonoscopy. Material and Methods In a double-blind, randomized controlled trial, subjects with a body mass index >= 35 kg/m(2) and insulin resistance were randomized, in a 1:1 ratio in blocks of four, to either allogenic (from healthy lean donor; n = 15) or autologous FMT (their own stool; n = 13) delivered in the caecum and were followed for 3 months. The main outcome was homeostatic model assessment of insulin resistance (HOMA-IR) and secondary outcomes were glycated haemoglobin levels, lipid profile, weight, gut hormones, endotoxin, appetite measures, intestinal microbiome (IM), metagenome, serum/faecal metabolites, quality of life, anxiety and depression scores. Results In the allogenic versus autologous groups, HOMA-IR and clinical variables did not change significantly, but IM and metabolites changed favourably (P < 0.05): at 1 month, Coprococcus, Bifidobacterium, Bacteroides and Roseburia increased, and Streptococcus decreased; at 3 months, Bacteroides and Blautia increased. Several species also changed significantly. For metabolites, at 1 month, serum kynurenine decreased and faecal indole acetic acid and butenylcarnitine increased, while at 3 months, serum isoleucine, leucine, decenoylcarnitine and faecal phenylacetic acid decreased. Metagenomic pathway representations and network analyses assessing relationships with clinical variables, metabolites and IM were significantly enhanced in the allogenic versus autologous groups. LDL and appetite measures improved in the allogenic (P < 0.05) but not in the autologous group. Conclusions Overall, in those with obeisty, allogenic FMT via colonoscopy induced favourable changes in IM, metabolites, pathway representations and networks even though other metabolic variables did not change. LDL and appetite variables may also benefit.
C1 [Ghorbani, Yasaman] Univ Toronto, Inst Med Sci, Toronto, ON, Canada.
   [Ghorbani, Yasaman; Schwenger, Katherine J. P.; Sharma, Divya; Allard, Johane P.] Univ Hlth Network, Toronto Gen Hosp, Toronto, ON, Canada.
   [Jung, Hyejung; Lou, Wendy] Univ Toronto, Dalla Lana Publ Hlth Dept, Toronto, ON, Canada.
   [Yadav, Jitender; Philpott, Dana] Univ Toronto, Dept Immunol, Toronto, ON, Canada.
   [Xu, Wei] Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON, Canada.
   [Poutanen, Susan] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada.
   [Poutanen, Susan] Sinai Hlth Syst, Dept Microbiol, Toronto, ON, Canada.
   [Poutanen, Susan; Hota, Susy S.; Gaisano, Herbert Y.; Allard, Johane P.] Univ Toronto, Dept Med, Toronto, ON, Canada.
   [Hota, Susy S.] Univ Hlth Network, Dept Med, Toronto, ON, Canada.
   [Hota, Susy S.] Univ Hlth Network, Infect Prevent & Control Dept, Toronto, ON, Canada.
   [Comelli, Elena M.; Allard, Johane P.] Univ Toronto, Dept Nutr Sci, Toronto, ON, Canada.
   [Jackson, Timothy D.; Okrainec, Allan] Univ Toronto, Div Gen Surg, Toronto, ON, Canada.
   [Jackson, Timothy D.; Okrainec, Allan] Univ Hlth Network, Toronto Western Hosp, Div Gen Surg, Toronto, ON, Canada.
C3 University of Toronto; University of Toronto; University Health Network
   Toronto; Toronto General Hospital; University of Toronto; University of
   Toronto; University of Toronto; University Health Network Toronto;
   Princess Margaret Cancer Centre; University of Toronto; University of
   Toronto; Sinai Health System Toronto; Lunenfeld Tanenbaum Research
   Institute; University of Toronto; University of Toronto; University
   Health Network Toronto; University of Toronto; University Health Network
   Toronto; University of Toronto; University of Toronto; University of
   Toronto; University Health Network Toronto
RP Allard, JP (corresponding author), Toronto Gen Hosp, Dept Med, Div Gastroenterol, 585 Univ Ave,9 N-973, Toronto, ON M5G 2N2, Canada.
EM dr.johane.allard@uhn.ca
RI Hota, Susy/L-1903-2019; Okrainec, Allan/AAD-2260-2021; SHARMA,
   DIVYA/JNS-2500-2023; Poutanen, Susan/N-8066-2019
FU Banting and Best Diabetes Centre, University of Toronto; Charles
   Hollenberg Summer Studentship; Canadian Institutes of Health Research
   [TB2-138775]
FX Banting and Best Diabetes Centre, University of Toronto and the Charles
   Hollenberg Summer Studentship; Canadian Institutes of Health Research,
   Grant/Award Number: TB2-138775
CR Affinati AH, 2019, CURR DIABETES REP, V19, DOI 10.1007/s11892-019-1269-4
   Akiba Y, 2014, J GASTROEN HEPATOL, V29, P93, DOI 10.1111/jgh.12731
   Allegretti JR, 2020, CLIN GASTROENTEROL H, V18, P855, DOI 10.1016/j.cgh.2019.07.006
   Banta JE, 2019, INT J FOOD SCI NUTR, V70, P759, DOI 10.1080/09637486.2019.1570085
   Bennett G, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.626432
   Burz SD, 2021, MICROORGANISMS, V9, DOI 10.3390/microorganisms9010199
   Carrizales-Sánchez AK, 2021, GUT MICROBES, V13, DOI 10.1080/19490976.2021.1960135
   Craven L, 2020, AM J GASTROENTEROL, V115, P1055, DOI 10.14309/ajg.0000000000000661
   De Souza LP, 2020, EXPERT REV PROTEOMIC, V17, P243, DOI 10.1080/14789450.2020.1766975
   de Vos WM, 2022, GUT, V71, P1020, DOI 10.1136/gutjnl-2021-326789
   Di Luccia B, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0134893
   Doll JPK, 2022, FRONT PSYCHIATRY, V13, DOI 10.3389/fpsyt.2022.815422
   Favennec M, 2015, OBESITY, V23, P2066, DOI 10.1002/oby.21199
   Gribble FM, 2019, NAT REV ENDOCRINOL, V15, P226, DOI 10.1038/s41574-019-0168-8
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Han H, 2021, MICROBIOME, V9, DOI 10.1186/s40168-021-01093-y
   Harrell L, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0032545
   He Y, 2019, FRONT CELL INFECT MI, V9, DOI 10.3389/fcimb.2019.00393
   Hota Susy S, 2019, J Assoc Med Microbiol Infect Dis Can, V4, P218, DOI 10.3138/jammi.2019-0003
   Hota SS, 2017, CLIN INFECT DIS, V64, P265, DOI 10.1093/cid/ciw731
   Hruby A, 2015, PHARMACOECONOMICS, V33, P673, DOI 10.1007/s40273-014-0243-x
   Hu T, 2016, BIOCOMPUT-PAC SYM, P120
   Jennis M, 2018, NEUROGASTROENT MOTIL, V30, DOI 10.1111/nmo.13178
   Jiang D, 2019, FRONT GENET, V10, DOI 10.3389/fgene.2019.00995
   Joisten N, 2021, TRENDS MOL MED, V27, P946, DOI 10.1016/j.molmed.2021.07.006
   Marín-Peñalver JJ, 2016, WORLD J DIABETES, V7, P354, DOI 10.4239/wjd.v7.i17.354
   Kasai C, 2015, BMC GASTROENTEROL, V15, DOI 10.1186/s12876-015-0330-2
   Kiluk M, 2021, J CLIN MED, V10, DOI 10.3390/jcm10112484
   Koopen AM, 2021, FRONT MICROBIOL, V12, DOI 10.3389/fmicb.2021.662159
   Kootte RS, 2017, CELL METAB, V26, P611, DOI 10.1016/j.cmet.2017.09.008
   Kuno T, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-19545-1
   Le Roy T, 2019, BMC BIOL, V17, DOI 10.1186/s12915-019-0715-8
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McCann MR, 2021, METABOLITES, V11, DOI 10.3390/metabo11010051
   Mocanu V, 2021, NAT MED, V27, P1272, DOI 10.1038/s41591-021-01399-2
   Napolitano M, 2020, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.590370
   Ng SC, 2022, GUT, V71, P716, DOI 10.1136/gutjnl-2020-323617
   Organization WH, 2021, Obesity and overweight
   Rodes L, 2011, ARTIF CELL BLOOD SUB, V39, P351, DOI 10.3109/10731199.2011.622280
   Roglic G, 2016, Global report on psoriasis
   Rudvik A, 2018, BMC MED RES METHODOL, V18, DOI 10.1186/s12874-018-0521-y
   Saad MJA, 2016, PHYSIOLOGY, V31, P283, DOI 10.1152/physiol.00041.2015
   Sarafidis PA, 2007, J HUM HYPERTENS, V21, P709, DOI 10.1038/sj.jhh.1002201
   Scheithauer TPM, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.571731
   Simmons RK, 2010, DIABETOLOGIA, V53, P600, DOI 10.1007/s00125-009-1620-4
   Small CJ, 2004, TRENDS ENDOCRIN MET, V15, P259, DOI 10.1016/j.tem.2004.06.002
   Tam CS, 2012, DIABETES CARE, V35, P1605, DOI 10.2337/dc11-2339
   Testerman T, 2022, HEPATOL COMMUN, V6, P1962, DOI 10.1002/hep4.1944
   Valles-Colomer M, 2019, NAT MICROBIOL, V4, P623, DOI 10.1038/s41564-018-0337-x
   van Beurden YH, 2017, UNITED EUR GASTROENT, V5, P868, DOI 10.1177/2050640616678099
   van der Vossen EWJ, 2021, GUT MICROBES, V13, DOI 10.1080/19490976.2021.1993513
   Venkatesh M, 2014, IMMUNITY, V41, P296, DOI 10.1016/j.immuni.2014.06.014
   Virani SS, 2021, CIRCULATION, V143, pe254, DOI 10.1161/CIR.0000000000000950
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wang H, 2020, FRONT CELL INFECT MI, V9, DOI 10.3389/fcimb.2019.00455
   Yang BB, 2019, GEN PSYCHIAT, V32, DOI 10.1136/gpsych-2019-100056
   Yu EW, 2020, PLOS MED, V17, DOI 10.1371/journal.pmed.1003051
   Zhang FY, 2016, EBIOMEDICINE, V13, P157, DOI 10.1016/j.ebiom.2016.10.013
   Zhang PP, 2020, ACTA PHARMACOL SIN, V41, P678, DOI 10.1038/s41401-019-0330-9
NR 59
TC 8
Z9 9
U1 2
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD FEB
PY 2023
VL 25
IS 2
BP 479
EP 490
DI 10.1111/dom.14891
EA OCT 2022
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 8R8WZ
UT WOS:000874477200001
PM 36239189
DA 2025-06-11
ER

PT J
AU Ng, AE
   Kubzansky, LD
   Guimond, AJ
   Trudel-Fitzgerald, C
AF Ng, Amanda E.
   Kubzansky, Laura D.
   Guimond, Anne-Josee
   Trudel-Fitzgerald, Claudia
TI Are There Sociodemographic-Specific Associations of Coping With Heart
   Disease and Diabetes Incidence?
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE coping; coping variability; cardiometabolic risk; diabetes; heart
   disease
ID CARDIOVASCULAR-DISEASE; HEALTH BEHAVIORS; RISK-FACTORS; LIFE;
   HYPERTENSION; STRATEGIES; ANXIETY; STRESS; FLEXIBILITY; DEPRESSION
AB Objective: Psychological factors, including psychological distress and well-being, have been associated with cardiometabolic disease risk. Here, we examined whether a psychological process, namely how individuals cope with stressors, relates to such risk, which has been understudied. Method: During 2004-2006, 2,142 participants without heart disease and diabetes from the Midlife in the U.S. study completed a validated coping inventory assessing six strategies (positive reinterpretation and growth, active coping, planning, focus on and venting of emotion, denial, and behavioral disengagement) and relevant covariates. As a proxy for coping flexibility, participants were also classified as having lower, moderate, or greater variability in their use of these strategies. Heart disease and diabetes were documented in 2013-2015. Logistic regressions modeled adjusted odds ratios (AORs) and 95% confidence intervals (CIs) of developing heart disease and diabetes, separately, with coping exposures. Results: In sociodemographic-adjusted models, greater use of adaptive strategies predicted lower diabetes risk (e.g., positive reinterpretation and growth: AOR = 0.83; 95% CI [0.72, 0.96]); estimates were weaker for maladaptive strategies, and all strategies were unrelated to heart disease. All associations for coping variability were null. In secondary analyses, greater use of adaptive strategies predicted lower heart disease risk in more educated participants only (e.g., active coping: AOR = 0.71; 95% CI [0.55, 0.92]) and lower diabetes risk in females only (e.g., planning: AOR = 0.75; 95% CI [0.61, 0.91]). Results were maintained additionally adjusting for health, behavioral, and social factors. Conclusions: Findings suggest sex and education differences in coping's association with heart disease and diabetes. Future studies should recognize adaptive strategies may be more potent for health among certain populations. Public Significance Statement Despite convincing evidence linking stressors and psychological distress to cardiometabolic disease risk, this is the first study examining the role of stress-related coping strategies and variability in their use in the onset of heart disease and diabetes. Results suggest the associations of coping with these conditions vary by sex and education levels, which underscores the importance of evaluating psychosocial interventions that are sociodemographic-specific to possibly prevent heart disease and diabetes.
C1 [Ng, Amanda E.] Univ Maryland, Sch Publ Hlth, Dept Epidemiol, College Pk, MD USA.
   [Kubzansky, Laura D.; Guimond, Anne-Josee] Harvard TH Chan Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA 02115 USA.
   [Guimond, Anne-Josee; Trudel-Fitzgerald, Claudia] Harvard TH Chan Sch Publ Hlth, Lee Kum Sheung Ctr Hlth & Happiness, Boston, MA USA.
   [Trudel-Fitzgerald, Claudia] Univ Quebec Trois Rivieres, Dept Psychol, 3600 Rue St Marguer, Trois Rivieres, PQ G9A5H7, Canada.
   [Trudel-Fitzgerald, Claudia] Inst Univ Sante Mentale Montreal, Montreal, PQ, Canada.
C3 University System of Maryland; University of Maryland College Park;
   Harvard University; Harvard T.H. Chan School of Public Health; Harvard
   University; Harvard T.H. Chan School of Public Health; University of
   Quebec; University of Quebec Trois Rivieres; Universite de Montreal
RP Trudel-Fitzgerald, C (corresponding author), Univ Quebec Trois Rivieres, Dept Psychol, 3600 Rue St Marguer, Trois Rivieres, PQ G9A5H7, Canada.
EM claudia.trudel-fitzgerald@uqtr.ca
RI Guimond, Anne-JosÃ©e/ABG-8892-2020
OI Trudel-Fitzgerald, Claudia/0000-0001-9989-4259; Ng,
   Amanda/0000-0002-5212-3147
FU John D. and Catherine T. MacArthur Foundation Research Network; National
   Institute on Aging [P01-AG020166, U19-AG051426]; Canadian Institutes of
   Health Research; Lee Kum Sheung Center for Health and Happiness at the
   Harvard T.H. Chan School of Public Health; National Institutes of Health
   [R25-AT0106641]
FX The Midlife in the United States (MIDUS) study has been funded by the
   John D. and Catherine T. MacArthur Foundation Research Network and the
   National Institute on Aging (P01-AG020166; U19-AG051426). Claudia
   Trudel-Fitzgerald is the Research Chair on Social Disparities, Coping,
   and Health at Universite du Quebec a Trois-Rivieres. Anne-Josee Guimond
   received a postdoctoral fellowship from the Canadian Institutes of
   Health Research. Claudia Trudel-Fitzgerald, Amanda E. Ng, and Anne-Josee
   Guimond received salary support from the Lee Kum Sheung Center for
   Health and Happiness at the Harvard T.H. Chan School of Public Health.
   This study was also informed by the Michigan Integrative Well-Being and
   Inequality Training Program, which is funded by a grant from the
   National Institutes of Health (R25-AT0106641)
CR Aldao A, 2015, COGNITIVE THER RES, V39, P263, DOI 10.1007/s10608-014-9662-4
   [Anonymous], 2022, Women and heart disease
   [Anonymous], 2020, DIETARY GUIDELINES A
   [Anonymous], 2022, Diabetes and Prediabetes
   [Anonymous], 2022, Heart disease facts
   Blanke ES, 2020, EMOTION, V20, P473, DOI 10.1037/emo0000566
   Bodner TE, 2008, STRUCT EQU MODELING, V15, P651, DOI 10.1080/10705510802339072
   Boehm JK, 2015, HEALTH PSYCHOL, V34, P1013, DOI 10.1037/hea0000200
   Boylan JM, 2015, PSYCHOSOM MED, V77, P548, DOI 10.1097/PSY.0000000000000192
   Brennan PL, 2012, AGING MENT HEALTH, V16, P305, DOI 10.1080/13607863.2011.628975
   Carver C. S., 2019, SELF REPORTED MEASUR
   CARVER CS, 1989, J PERS SOC PSYCHOL, V56, P267, DOI 10.1037/0022-3514.56.2.267
   Chen E, 2012, PERSPECT PSYCHOL SCI, V7, P135, DOI 10.1177/1745691612436694
   Cheng C, 2001, J PERS SOC PSYCHOL, V80, P814, DOI 10.1037//3415.80.5.814
   Cheng C, 2014, PSYCHOL BULL, V140, P1582, DOI 10.1037/a0037913
   Chiuve SE, 2008, CIRCULATION, V118, P947, DOI 10.1161/CIRCULATIONAHA.108.781062
   Cohen BE, 2015, AM J HYPERTENS, V28, P1295, DOI 10.1093/ajh/hpv047
   Crump C, 2016, HEART, V102, P541, DOI 10.1136/heartjnl-2015-308597
   De France K, 2022, PSYCHONEUROENDOCRINO, V144, DOI 10.1016/j.psyneuen.2022.105872
   Demmer RT, 2015, PSYCHOSOM MED, V77, P467, DOI 10.1097/PSY.0000000000000169
   Farvid MS, 2014, BRAIN BEHAV IMMUN, V36, P176, DOI 10.1016/j.bbi.2013.10.025
   Felix AS, 2019, J URBAN HEALTH, V96, P12, DOI 10.1007/s11524-018-00333-1
   Hackett RA, 2016, CURR CARDIOL REP, V18, DOI 10.1007/s11886-016-0771-4
   Kato T, 2015, STRESS HEALTH, V31, P315, DOI 10.1002/smi.2557
   Kim ES, 2014, CIRC-HEART FAIL, V7, P394, DOI 10.1161/CIRCHEARTFAILURE.113.000644
   Lazarus R. S., 1990, Psychological Inquiry, V1, P3, DOI 10.1207/s15327965pli0101_1
   Lazarus R. S., 1984, STRESS APPRAISAL COP, DOI DOI 10.1002/PER.2410010304
   Levine GN, 2021, CIRCULATION, V143, pE763, DOI 10.1161/CIR.0000000000000947
   Martín-Timón I, 2014, WORLD J DIABETES, V5, P444, DOI 10.4239/wjd.v5.i4.444
   Mezuk B, 2013, SOC MENT HEALTH, V3, P79, DOI 10.1177/2156869313480892
   Moore J.C., 1999, Cognition and survey research, P155
   Nikolaev BN, 2023, ENTREP THEORY PRACT, V47, P2121, DOI 10.1177/10422587221126486
   Okely JA, 2016, PSYCHOSOM MED, V78, P335, DOI 10.1097/PSY.0000000000000279
   Okura Y, 2004, J CLIN EPIDEMIOL, V57, P1096, DOI 10.1016/j.jclinepi.2004.04.005
   Park CL, 2014, ANXIETY STRESS COPIN, V27, P123, DOI 10.1080/10615806.2013.860969
   Penley JA, 2002, J BEHAV MED, V25, P551, DOI 10.1023/A:1020641400589
   Radler BT, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-017-0646-8
   Roohafza H, 2022, EUR J CARDIOVASC NUR, V21, P483, DOI 10.1093/eurjcn/zvab110
   Roth GA, 2020, J AM COLL CARDIOL, V76, P2982, DOI 10.1016/j.jacc.2020.11.010
   Ryff CD, 2014, PSYCHOTHER PSYCHOSOM, V83, P10, DOI 10.1159/000353263
   Sheeran P, 2013, HEALTH PSYCHOL, V32, P460, DOI 10.1037/a0029203
   Stone AA, 1998, J PERS SOC PSYCHOL, V74, P1670, DOI 10.1037/0022-3514.74.6.1670
   Svensson T, 2016, EUR HEART J, V37, P890, DOI 10.1093/eurheartj/ehv724
   Trudel-Fitzgerald C., 2024, HDB EMOTION REGULATI, P465
   Trudel-Fitzgerald C, 2022, J PSYCHOSOM RES, V162, DOI 10.1016/j.jpsychores.2022.111035
   Trudel-Fitzgerald C, 2022, PSYCHONEUROENDOCRINO, V144, DOI 10.1016/j.psyneuen.2022.105874
   Trudel-Fitzgerald C, 2017, CURR OPIN BEHAV SCI, V15, P16, DOI 10.1016/j.cobeha.2017.05.003
   Trudel-Fitzgerald C, 2014, J HYPERTENS, V32, P1222, DOI 10.1097/HJH.0000000000000175
NR 48
TC 3
Z9 3
U1 0
U2 5
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD OCT
PY 2024
VL 43
IS 10
BP 757
EP 767
DI 10.1037/hea0001386
EA JUN 2024
PG 11
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA I1H8P
UT WOS:001300852500001
PM 38884978
DA 2025-06-11
ER

PT J
AU Machado, MV
   Michelotti, GA
   Jewell, ML
   Pereira, TA
   Xie, G
   Premont, RT
   Diehl, AM
AF Machado, M. V.
   Michelotti, G. A.
   Jewell, M. L.
   Pereira, T. A.
   Xie, G.
   Premont, R. T.
   Diehl, A. M.
TI Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic
   fatty liver disease
SO CELL DEATH & DISEASE
LA English
DT Article
ID WHITE ADIPOSE-TISSUE; GENE-EXPRESSION; CELL-SIZE; CASPASE-2-DEFICIENT
   MICE; INSULIN-RESISTANCE; HEPATIC STEATOSIS; OXIDATIVE STRESS; ADIPOCYTE
   DEATH; APOPTOSIS; REGULATOR
AB Obesity and its resulting metabolic disturbances are major health threats. In response to energy surplus, overtaxed adipocytes release fatty acids and pro-inflammatory factors into the circulation, promoting organ fat accumulation (including nonalcoholic fatty liver disease), insulin resistance and the metabolic syndrome. Recently, caspase-2 was linked to lipoapoptosis, so we hypothesized that caspase-2 might be a critical determinant of metabolic syndrome pathogenesis. Caspase-2-deficient and wildtype mice were fed a Western diet (high-fat diet, enriched with saturated fatty acids and 0.2% cholesterol, supplemented with fructose and glucose in the drinking water) for 16 weeks. Metabolic and hepatic outcomes were evaluated. In vitro studies assessed the role of caspase-2 in adipose tissue proliferative properties and susceptibility for lipoapoptosis. Caspase-2-deficient mice fed a Western diet were protected from abdominal fat deposition, diabetes mellitus, dyslipidemia and hepatic steatosis. Adipose tissue in caspase-2-deficient mice was more proliferative, upregulated mitochondrial uncoupling proteins consistent with browning, and was resistant to cell hypertrophy and cell death. The liver was protected from steatohepatitis through a decrease in circulating fatty acids and more efficient hepatic fat metabolism, and from fibrosis as a consequence of reduced fibrogenic stimuli from fewer lipotoxic hepatocytes. Caspase-2 deficiency protected mice from diet-induced obesity, metabolic syndrome and nonalcoholic fatty liver disease. Further studies are necessary to assess caspase-2 as a therapeutic target for those conditions.
C1 [Machado, M. V.; Michelotti, G. A.; Jewell, M. L.; Pereira, T. A.; Xie, G.; Premont, R. T.; Diehl, A. M.] Duke Univ, Med Ctr, Dept Med, Div Gastroenterol, 905S LaSalle St,Snyderman Bldg,Suite 1073, Durham, NC 27710 USA.
   [Machado, M. V.] Hosp Santa Maria, Dept Gastroenterol, Lisbon, Portugal.
C3 Duke University; Universidade de Lisboa; Hospital Santa Maria
RP Diehl, AM (corresponding author), Duke Univ, Med Ctr, Dept Med, Div Gastroenterol, 905S LaSalle St,Snyderman Bldg,Suite 1073, Durham, NC 27710 USA.
EM diehl004@mc.duke.edu
RI de Almeida Pereira, Thiago/E-3092-2013
OI de Almeida Pereira, Thiago/0000-0002-8755-0683; Premont, Richard
   T./0000-0002-8053-5026; , Gregory/0000-0002-3936-4675
FU NIH [DK0077794, DK053792, R37 AA010154]; Duke Endowment: The Florence
   McAlister Professorship; FCT, Portugal
FX We thank Sally Kornbluth, Ph.D., for helpful discussions, and Farshid
   Guilak, Ph.D., for helping us to perform DXA experiments. This research
   is supported by NIH DK0077794, DK053792 and R37 AA010154 (Diehl AM), and
   Duke Endowment: The Florence McAlister Professorship (Diehl AM). MVM is
   a receiver of a Ph.D. grant from FCT, Portugal.
CR Ahmadian M, 2013, NAT MED, V19, P557, DOI 10.1038/nm.3159
   Al-Goblan AS, 2014, DIABETES METAB SYNDR, V7, P587, DOI 10.2147/DMSO.S67400
   Alkhouri N, 2010, J BIOL CHEM, V285, P3428, DOI 10.1074/jbc.M109.074252
   Andersen JL, 2009, EMBO J, V28, P3216, DOI 10.1038/emboj.2009.253
   Angulo P, 2015, GASTROENTEROLOGY, V149, P389, DOI 10.1053/j.gastro.2015.04.043
   [Anonymous], OB OV
   Anstee QM, 2013, NAT REV GASTRO HEPAT, V10, P330, DOI 10.1038/nrgastro.2013.41
   Bi PP, 2014, NAT MED, V20, P911, DOI 10.1038/nm.3615
   Bouchier-Hayes L, 2012, CELL DEATH DIFFER, V19, P51, DOI 10.1038/cdd.2011.157
   Cancello R, 2005, DIABETES, V54, P2277, DOI 10.2337/diabetes.54.8.2277
   Carobbio S, 2013, DIABETES, V62, P3697, DOI 10.2337/db12-1748
   Cheung KJ, 2007, CELL METAB, V5, P115, DOI 10.1016/j.cmet.2007.01.005
   Cinti S, 2005, J LIPID RES, V46, P2347, DOI 10.1194/jlr.M500294-JLR200
   Farnier C, 2003, INT J OBESITY, V27, P1178, DOI 10.1038/sj.ijo.0802399
   Feng RN, 2014, WORLD J GASTROENTERO, V20, P17932, DOI 10.3748/wjg.v20.i47.17932
   Gitenay D, 2014, ONCOTARGET, V5, P5845, DOI 10.18632/oncotarget.2286
   Goossens GH, 2015, FRONT ENDOCRINOL, V6, DOI 10.3389/fendo.2015.00055
   Grundy SM, 2004, ARTERIOSCL THROM VAS, V24, pE13, DOI 10.1161/01.ATV.0000111245.75752.C6
   Guha M, 2010, ONCOGENE, V29, P1280, DOI 10.1038/onc.2009.428
   Heinonen S, 2014, INT J OBESITY, V38, P1423, DOI 10.1038/ijo.2014.31
   Ho LH, 2009, P NATL ACAD SCI USA, V106, P5336, DOI 10.1073/pnas.0811928106
   Jobgen W, 2009, AMINO ACIDS, V37, P187, DOI 10.1007/s00726-009-0246-7
   Johnson ES, 2013, J BIOL CHEM, V288, P14463, DOI 10.1074/jbc.M112.437210
   Tinahones FJ, 2013, DIABETES CARE, V36, P513, DOI 10.2337/dc12-0194
   Kasuga M, 2006, J CLIN INVEST, V116, P1756, DOI 10.1172/JCI29189
   Keuper M, 2013, CELL DEATH DIS, V4, DOI 10.1038/cddis.2012.212
   Khan T, 2009, MOL CELL BIOL, V29, P1575, DOI 10.1128/MCB.01300-08
   Klöting N, 2014, REV ENDOCR METAB DIS, V15, P277, DOI 10.1007/s11154-014-9301-0
   Kumar S, 1997, CELL DEATH DIFFER, V4, P2, DOI 10.1038/sj.cdd.4400208
   Le Lay S, 2001, J BIOL CHEM, V276, P16904, DOI 10.1074/jbc.M010955200
   Machado MV, 2015, GUT, V64, P1148, DOI 10.1136/gutjnl-2014-307362
   Machado MV, 2014, EXPERT REV GASTROENT, V8, P487, DOI 10.1586/17474124.2014.903798
   Michelotti GA, 2013, J CLIN INVEST, V123, P2380, DOI 10.1172/JCI66904
   Nutt LK, 2005, CELL, V123, P89, DOI 10.1016/j.cell.2005.07.032
   Oliveira RB, 2015, ANN ANAT, V200, P88, DOI 10.1016/j.aanat.2015.01.007
   Oliver TG, 2011, MOL CELL, V43, P57, DOI 10.1016/j.molcel.2011.06.012
   Olsson M, 2015, ONCOGENE, V34, P1877, DOI 10.1038/onc.2014.139
   Omenetti A, 2008, J CLIN INVEST, V118, P3331, DOI 10.1172/JCI35875
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Petäjä EM, 2013, OBESITY, V21, P1174, DOI 10.1002/oby.20114
   Rutkowski JM, 2015, J CELL BIOL, V208, P501, DOI 10.1083/jcb.201409063
   Shalini S, 2012, CELL DEATH DIFFER, V19, P1370, DOI 10.1038/cdd.2012.13
   Sjögren K, 2001, J NUTR, V131, P2963, DOI 10.1093/jn/131.11.2963
   Smagris E, 2015, HEPATOLOGY, V61, P108, DOI 10.1002/hep.27242
   Stenson BM, 2011, J BIOL CHEM, V286, P370, DOI 10.1074/jbc.M110.179499
   Stiles B, 2004, P NATL ACAD SCI USA, V101, P2082, DOI 10.1073/pnas.0308617100
   Strissel KJ, 2007, DIABETES, V56, P2910, DOI 10.2337/db07-0767
   Sun Z, 2012, NAT MED, V18, P934, DOI 10.1038/nm.2744
   Tao HL, 2014, NAT MED, V20, P1263, DOI 10.1038/nm.3699
   Tiwari M, 2014, AUTOPHAGY, V10, P1054, DOI 10.4161/auto.28528
   Tsakiridis T, 1997, SOC GEN PHY, V52, P257
   Vemuri MC, 2011, METHODS MOL BIOL, V698, P1, DOI 10.1007/978-1-60761-999-4
   Wajchenberg BL, 2002, HORM METAB RES, V34, P616, DOI 10.1055/s-2002-38256
   Wilson CH, 2015, CELL DEATH DIS, V6, DOI 10.1038/cddis.2014.567
   Wree A, 2014, METABOLISM, V63, P1542, DOI 10.1016/j.metabol.2014.09.001
   Xiao L, 2013, INT J OBESITY, V40, P112
   Xu XJ, 2012, J LIPID RES, V53, P792, DOI 10.1194/jlr.P022905
   Yi P, 2013, CELL, V153, P747, DOI 10.1016/j.cell.2013.04.008
   Yki-Järvinen H, 2014, LANCET DIABETES ENDO, V2, P901, DOI 10.1016/S2213-8587(14)70032-4
   Zebisch K, 2012, ANAL BIOCHEM, V425, P88, DOI 10.1016/j.ab.2012.03.005
   Zhang YP, 2007, MECH AGEING DEV, V128, P213, DOI 10.1016/j.mad.2006.11.030
NR 61
TC 40
Z9 46
U1 0
U2 9
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-4889
J9 CELL DEATH DIS
JI Cell Death Dis.
PD FEB
PY 2016
VL 7
AR e2096
DI 10.1038/cddis.2016.19
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA DR3GS
UT WOS:000379791300008
PM 26890135
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sandoval-Bórquez, A
   Carrión, P
   Hernández, MP
   Pérez, JA
   Tapia-Castillo, A
   Vecchiola, A
   Fardella, CE
   Carvajal, CA
AF Sandoval-Borquez, Alejandra
   Carrion, Pablo
   Hernandez, Maria Paz
   Perez, Jorge A.
   Tapia-Castillo, Alejandra
   Vecchiola, Andrea
   Fardella, Carlos E.
   Carvajal, Cristian A.
TI Adipose Tissue Dysfunction and the Role of Adipocyte-Derived
   Extracellular Vesicles in Obesity and Metabolic Syndrome
SO JOURNAL OF THE ENDOCRINE SOCIETY
LA English
DT Review
DE obesity; metabolic syndrome; adipocyte-derived extracellular vesicles
   (AdEVs)
ID EXOSOMAL MIRNAS; CELL; INFLAMMATION; BIOGENESIS; SECRETION; MECHANISM;
   PROTEINS
AB Obesity is a major public health issue that is associated with metabolic diseases including diabetes mellitus type 2 and metabolic syndrome. This pathology leads to detrimental cardiovascular health and secondary effects, such as lipotoxicity, inflammation, and oxidative stress. Recently, extracellular vesicles (EVs) have been highlighted as novel players participating in human physiology and pathophysiology. In obesity, adipose tissue is related to the active shedding of adipocyte-derived extracellular vesicles (AdEVs). The current review explores and highlights the role of AdEVs and their cargo in obesity and metabolic syndrome. AdEVs are proposed to play an important role in obesity and its comorbidities. AdEVs are biological nanoparticles mainly shed by visceral and subcutaneous adipose tissue, acting in physiological and pathophysiological conditions, and also carrying different cargo biomolecules, such as RNA, microRNA (miRNA), proteins, and lipids, among others. RNA and miRNA have local and systemic effects affecting gene expression in target cell types via paracrine and endocrine actions. State of the art analyses identified some miRNAs, such as miR-222, miR-23b, miR-4429, miR-148b, and miR-4269, that could potentially affect cell pathways involved in obesity-related comorbidities, such as chronic inflammation and fibrosis. Similarly, AdEVs-proteins (RBP4, perilipin-A, FABP, mimecan, TGFBI) and AdEVs-lipids (sphingolipids) have been linked to the obesity pathophysiology. The current knowledge about AdEVs along with further research would support and reveal novel pathways, potential biomarkers, and therapeutic options in obesity.
C1 [Sandoval-Borquez, Alejandra] Pontificia Univ Catolica Valparaiso, Fac Sci, Sch Med Technol, Valparaiso 2373223, Chile.
   [Carrion, Pablo; Hernandez, Maria Paz; Perez, Jorge A.; Tapia-Castillo, Alejandra; Vecchiola, Andrea; Fardella, Carlos E.; Carvajal, Cristian A.] Pontificia Univ Catolica Chile, Ctr Translat Res Endocrinol CETREN UC, Santiago 8330074, Chile.
   [Carrion, Pablo; Hernandez, Maria Paz; Perez, Jorge A.; Tapia-Castillo, Alejandra; Vecchiola, Andrea; Fardella, Carlos E.; Carvajal, Cristian A.] Pontificia Univ Catolica Chile, Sch Med, Dept Endocrinol, Santiago 8330077, Chile.
C3 Pontificia Universidad Catolica de Valparaiso; Pontificia Universidad
   Catolica de Chile; Pontificia Universidad Catolica de Chile
RP Fardella, CE; Carvajal, CA (corresponding author), Pontificia Univ Catolica Chile, Escuela Med, Dept Endocrinol, Diagonal Paraguay 362,Piso 4, Santiago 8330077, Chile.
EM cfardella@med.puc.cl; ccarvajm@uc.cl
RI Sandoval, Alejandra/HKV-3194-2023; Carvajal, Cristian/HLH-7846-2023
OI TAPIA-CASTILLO, ALEJANDRA/0000-0002-6081-1468; Sandoval-Borquez,
   Alejandra/0000-0002-1632-6449; Perez, Jorge A./0000-0003-4745-6219;
   Carrion Valdes, Pablo Alejandro/0009-0009-4431-219X; Hernandez Mejias,
   Maria Paz/0009-0002-0877-8055
FU ANID- CONICYT FONDECYT [1212006]; FONDECYT POSTDOCTORAL [3200646, SOCHED
   2023-09]; CETREN-UC
FX This work was supported by the following grants: ANID- CONICYT FONDECYT
   1212006; FONDECYT POSTDOCTORAL 3200646, SOCHED 2023-09, and CETREN-UC.
CR Akhmetshina A, 2012, NAT COMMUN, V3, DOI 10.1038/ncomms1734
   ARAKI E, 1994, NATURE, V372, P186, DOI 10.1038/372186a0
   Badman MK, 2007, CELL METAB, V5, P426, DOI 10.1016/j.cmet.2007.05.002
   Barros ER, 2021, ENDOCRINOLOGY, V162, DOI 10.1210/endocr/bqab032
   Blandin A, 2023, CELL REP, V42, DOI 10.1016/j.celrep.2023.112169
   Bond ST, 2022, FRONT PHYSIOL, V13, DOI 10.3389/fphys.2022.837001
   Booth A, 2014, HORM MOL BIOL CLIN I, V17, P13, DOI 10.1515/hmbci-2014-0009
   Brasaemle DL, 2007, J LIPID RES, V48, P2547, DOI 10.1194/jlr.R700014-JLR200
   Camino T, 2022, TRANSL RES, V239, P85, DOI 10.1016/j.trsl.2021.01.006
   Camino T, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21062252
   Carvajal CA, 2022, ENDOCRINOLOGY, V163, DOI 10.1210/endocr/bqab240
   Christovam AC, 2019, ARCH DERMATOL RES, V311, P193, DOI 10.1007/s00403-019-01901-4
   Clement E, 2020, EMBO J, V39, DOI 10.15252/embj.2019102525
   Colombo M, 2014, ANNU REV CELL DEV BI, V30, P255, DOI 10.1146/annurev-cellbio-101512-122326
   Connolly KD, 2018, ENDOCRINOLOGY, V159, P3259, DOI 10.1210/en.2018-00266
   Crewe C, 2018, CELL, V175, P695, DOI 10.1016/j.cell.2018.09.005
   Crewe C, 2017, J CLIN INVEST, V127, P74, DOI 10.1172/JCI88883
   Deng ZB, 2009, DIABETES, V58, P2498, DOI 10.2337/db09-0216
   Doyle LM, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8070727
   Duis J, 2022, ADV BIOL-GER, V6, DOI 10.1002/adbi.202101154
   Eguchi A, 2016, J MOL MED, V94, P1241, DOI 10.1007/s00109-016-1446-8
   Ferrante SC, 2015, PEDIATR RES, V77, P447, DOI 10.1038/pr.2014.202
   Ghaben AL, 2019, NAT REV MOL CELL BIO, V20, P242, DOI 10.1038/s41580-018-0093-z
   Hong PY, 2019, STEM CELL RES THER, V10, DOI 10.1186/s13287-019-1358-y
   Huang Z, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.608680
   Iannotta D, 2021, NANO TODAY, V39, DOI 10.1016/j.nantod.2021.101159
   Iqbal J, 2018, CURR DIABETES REV, V14, P427, DOI 10.2174/1573399813666170705161039
   Jiang M, 2018, CELL PHYSIOL BIOCHEM, V47, P864, DOI [10.1159/000490078and, 10.1159/000490078]
   Jin J, 2020, BIOMED RES INT, V2020, DOI 10.1155/2020/2685305
   Jin J, 2019, STEM CELL RES THER, V10, DOI 10.1186/s13287-019-1177-1
   Kahn CR, 2019, J CLIN INVEST, V129, P3990, DOI 10.1172/JCI129187
   Kao CY, 2019, CURR OPIN BIOTECH, V60, P89, DOI 10.1016/j.copbio.2019.01.005
   Keshtkar S, 2018, STEM CELL RES THER, V9, DOI 10.1186/s13287-018-0791-7
   Kwan HY, 2021, CELL MOL LIFE SCI, V78, P7275, DOI 10.1007/s00018-021-03973-w
   Lavin DP, 2016, DIABETOLOGIA, V59, P2280, DOI 10.1007/s00125-016-4072-7
   Lazar I, 2016, CANCER RES, V76, P4051, DOI 10.1158/0008-5472.CAN-16-0651
   Le Lay S, 2021, FASEB BIOADV, V3, P407, DOI 10.1096/fba.2020-00147
   Le Magueresse-Battistoni Brigitte, 2017, World J Biol Chem, V8, P108, DOI 10.4331/wjbc.v8.i2.108
   Li B, 2020, MOL THER-NUCL ACIDS, V19, P814, DOI 10.1016/j.omtn.2019.11.034
   Liu HH, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.725598
   Liu JW, 2018, MOL THER-NUCL ACIDS, V11, P103, DOI 10.1016/j.omtn.2018.01.010
   Liu T, 2019, BIOCHEM BIOPH RES CO, V515, P352, DOI 10.1016/j.bbrc.2019.05.113
   Luo QC, 2017, CELL PHYSIOL BIOCHEM, V44, P2105, DOI 10.1159/000485949
   Martin-Taboada M, 2021, NEPHRON, V145, P609, DOI 10.1159/000515418
   Meyer LK, 2013, ADIPOCYTE, V2, P217, DOI 10.4161/adip.24953
   Mleczko J, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700917
   Pan JJ, 2019, J CELL BIOCHEM, V120, P4433, DOI 10.1002/jcb.27731
   Park HK, 2023, BEST PRACT RES CL OB, V90, DOI 10.1016/j.bpobgyn.2023.102394
   Reilly SM, 2017, NAT REV ENDOCRINOL, V13, P633, DOI 10.1038/nrendo.2017.90
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Rome S, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22041788
   Sandoval-Bórquez A, 2015, DIS MARKERS, V2015, P1, DOI 10.1155/2015/503762
   Shi RF, 2020, AM J PHYSIOL-CELL PH, V318, pC848, DOI 10.1152/ajpcell.00041.2020
   Si ZZ, 2019, BIOMED PHARMACOTHER, V114, DOI 10.1016/j.biopha.2019.108765
   Song HC, 2020, AGING-US, V12, P22719, DOI 10.18632/aging.103891
   Song M, 2018, CELL PHYSIOL BIOCHEM, V48, P1416, DOI 10.1159/000492252
   Ståhl AL, 2019, PEDIATR NEPHROL, V34, P11, DOI 10.1007/s00467-017-3816-z
   Tapia-Castillo A, 2019, J TRANSL MED, V17, DOI 10.1186/s12967-019-02143-8
   Théry C, 2002, NAT REV IMMUNOL, V2, P569, DOI 10.1038/nri855
   Thomou T, 2017, NATURE, V542, P450, DOI 10.1038/nature21365
   Tkach M, 2016, CELL, V164, P1226, DOI 10.1016/j.cell.2016.01.043
   van Niel G, 2018, NAT REV MOL CELL BIO, V19, P213, DOI 10.1038/nrm.2017.125
   Wharton S, 2018, DIABET METAB SYND OB, V11, P427, DOI 10.2147/DMSO.S171365
   Wu J, 2012, CELL, V150, P366, DOI 10.1016/j.cell.2012.05.016
   Wu YL, 2022, INT J NANOMED, V17, P6113, DOI 10.2147/IJN.S390378
   Yang XB, 2023, MOL MED REP, V28, DOI 10.3892/mmr.2023.13076
   Ying W, 2017, CELL, V171, P372, DOI 10.1016/j.cell.2017.08.035
   Zhao H, 2018, DIABETES, V67, P235, DOI 10.2337/db17-0356
   Zhou YL, 2020, FRONT MOL BIOSCI, V7, DOI 10.3389/fmolb.2020.00171
NR 69
TC 1
Z9 1
U1 3
U2 3
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
EI 2472-1972
J9 J ENDOCR SOC
JI J. Endocr. Soc.
PD JUL 10
PY 2024
VL 8
IS 8
AR bvae126
DI 10.1210/jendso/bvae126
PG 8
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA YH1G4
UT WOS:001267499700002
PM 38988671
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Feraco, A
   Marzolla, V
   Scuteri, A
   Armani, A
   Caprio, M
AF Feraco, Alessandra
   Marzolla, Vincenzo
   Scuteri, Angelo
   Armani, Andrea
   Caprio, Massimiliano
TI Mineralocorticoid Receptors in Metabolic Syndrome: From Physiology to
   Disease
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID BROWN ADIPOSE-TISSUE; PROSTAGLANDIN D SYNTHASE; ENDOTHELIAL FUNCTION;
   ARTERIAL STIFFNESS; OXIDATIVE STRESS; GLUCOCORTICOID-RECEPTOR; ADIPOCYTE
   DYSFUNCTION; PRIMARY ALDOSTERONISM; VASCULAR DYSFUNCTION;
   GENE-TRANSCRIPTION
AB Over the past decade, several studies have shown that activity of extra-renal mineralocorticoid receptors (MR) regulates vascular tone, adipogenesis, adipose tissue function, and cardiomyocyte contraction. In mice, abnormal activation of MR in the vasculature and in adipose tissue favors the occurrence of several components of the metabolic syndrome (MetS), such as hypertension, obesity, and glucose intolerance. Accordingly, high levels of aldosterone are associated with obesity and MetS in humans, suggesting that altered activation of aldosterone-MR system in extra-renal tissues leads to profound metabolic dysfunctions. In this context, in addition to the classical indications for heart failure and hypertension, MR antagonists (MRAs) nowadays represent a promising approach to tackle cardiovascular and metabolic disorders occurring in the MetS.
C1 [Feraco, Alessandra; Marzolla, Vincenzo; Armani, Andrea; Caprio, Massimiliano] IRCCS San Raffaele Pisana, Lab Cardiovasc Endocrinol, Rome, Italy.
   [Scuteri, Angelo] Univ Sassari, Dept Med Surg & Expt Sci, Sassari, Italy.
   [Caprio, Massimiliano] San Raffaele Roma Open Univ, Dept Human Sci & Promot Qual Life, Rome, Italy.
C3 IRCCS San Raffaele Pisana; University of Sassari
RP Caprio, M (corresponding author), IRCCS San Raffaele Pisana, Lab Cardiovasc Endocrinol, Rome, Italy.; Caprio, M (corresponding author), San Raffaele Roma Open Univ, Dept Human Sci & Promot Qual Life, Rome, Italy.
EM massimiliano.caprio@sanraffaele.it
RI Armani, Andrea/AAC-2071-2022; Feraco, Alessandra/K-5920-2016; Caprio,
   Massimiliano/J-3020-2012; Marzolla, Vincenzo/K-7769-2016
OI Feraco, Alessandra/0000-0002-7074-0480; SCUTERI,
   ANGELO/0000-0003-4784-5441; Caprio, Massimiliano/0000-0003-0722-7163;
   Marzolla, Vincenzo/0000-0002-2943-7631
FU Italian Ministry of Health [GR-2013-02357959]; MIUR [2015ZTT5KB]; Bayer
   AG
FX This work was supported by funding from the Italian Ministry of Health
   (Ricerca Corrente; Bando Giovani Ricercatori 2013 project grant
   GR-2013-02357959 to A.F., Principal Investigator) and by a grant of MIUR
   (Progetti di Ricerca di Interesse Nazionale 2015, project code
   2015ZTT5KB, to M.C., Work Package Leader). M.C. received research grants
   from Bayer AG. The other authors declare no conflicts of interest.
   Figure generation has been performed using BioRender.
CR Abiose AK, 2004, AM J CARDIOL, V93, P1564, DOI 10.1016/j.amjcard.2004.03.015
   [Anonymous], CAN J KIDNEY HLTH DI
   [Anonymous], CRIT REV CLIN LAB SC
   [Anonymous], INT J OBES
   [Anonymous], J HYPERTENS
   [Anonymous], 2011, ENDOCRINOLOGY
   [Anonymous], J VIS EXP
   [Anonymous], ATHEROSSCLEROSIS
   Armani A, 2014, INT J OBESITY, V38, P1580, DOI 10.1038/ijo.2014.68
   Armani A, 2019, DIABETES OBES METAB, V21, P2024, DOI 10.1111/dom.13756
   Armani A, 2017, FASEB J, V31, P4240, DOI 10.1096/fj.201601125RRR
   Armani A, 2015, J MOL ENDOCRINOL, V55, pR1, DOI 10.1530/JME-15-0122
   Armani A, 2014, FASEB J, V28, P3745, DOI 10.1096/fj.13-245415
   Asada M, 2011, LAB INVEST, V91, P203, DOI 10.1038/labinvest.2010.170
   Barrett KV, 2013, CLIN EXP PHARMACOL P, V40, P902, DOI 10.1111/1440-1681.12125
   Bauerle KT, 2018, ENDOCRINOLOGY, V159, P2050, DOI 10.1210/en.2018-00118
   Bentzon JF, 2014, CIRC RES, V114, P1852, DOI 10.1161/CIRCRESAHA.114.302721
   Byrd JB, 2018, CIRCULATION, V138, P823, DOI 10.1161/CIRCULATIONAHA.118.033597
   Callera GE, 2005, HYPERTENSION, V45, P773, DOI 10.1161/01.HYP.0000154365.30593.d3
   Caprio M, 2008, CIRC RES, V102, P1359, DOI 10.1161/CIRCRESAHA.108.174235
   Caprio M, 2007, FASEB J, V21, P2185, DOI 10.1096/fj.06-7970com
   Caprio M, 2011, ENDOCRINOLOGY, V152, P113, DOI 10.1210/en.2010-0674
   Cat AND, 2016, DIABETES, V65, P2392, DOI 10.2337/db15-1627
   Cat AND, 2010, FASEB J, V24, P2454, DOI 10.1096/fj.09-147926
   Catena C, 2006, J CLIN ENDOCR METAB, V91, P3457, DOI 10.1210/jc.2006-0736
   Chistiakov DA, 2015, ACTA PHYSIOL, V214, P33, DOI 10.1111/apha.12466
   Chowdhury A, 2011, BIOCHEM BIOPH RES CO, V411, P287, DOI 10.1016/j.bbrc.2011.06.126
   Cinti S, 2018, COMPR PHYSIOL, V8, P1357, DOI 10.1002/cphy.c170042
   Clauss M, 1996, J BIOL CHEM, V271, P17629, DOI 10.1074/jbc.271.30.17629
   Clemmensen C, 2019, NAT REV ENDOCRINOL, V15, P90, DOI 10.1038/s41574-018-0118-x
   Cohen P, 2016, MOL BIOL CELL, V27, P2523, DOI 10.1091/mbc.E15-10-0749
   Davel AP, 2017, CURR OPIN NEPHROL HY, V26, P97, DOI 10.1097/MNH.0000000000000306
   de Rita O, 2012, CAN J CARDIOL, V28, P706, DOI 10.1016/j.cjca.2012.04.014
   Desarzens S, 2016, J ENDOCRINOL, V230, P1, DOI 10.1530/JOE-16-0121
   DuPont JJ, 2016, JCI INSIGHT, V1, DOI 10.1172/jci.insight.88942
   Fallo F, 2006, J CLIN ENDOCR METAB, V91, P454, DOI 10.1210/jc.2005-1733
   Farquharson CAJ, 2000, CIRCULATION, V101, P594, DOI 10.1161/01.CIR.101.6.594
   Farquharson CAJ, 2002, CLIN SCI, V103, P425, DOI 10.1042/cs1030425
   Feraco A, 2018, J ENDOCRINOL, V239, P229, DOI [10.1530/JOE-18-0314, 10.1530/joe-18-0314]
   Ferhat M, 2019, ANTIOXID REDOX SIGN, V31, P487, DOI 10.1089/ars.2018.7626
   Filippatos G, 2016, EUR HEART J, V37, P2105, DOI 10.1093/eurheartj/ehw132
   Förstermann U, 2012, EUR HEART J, V33, P829, DOI 10.1093/eurheartj/ehr304
   Funder JW, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18051032
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Garg R, 2014, DIABETES OBES METAB, V16, P268, DOI 10.1111/dom.12224
   Garg R, 2015, DIABETES, V64, P236, DOI 10.2337/db14-0670
   Ghadge AA, 2019, CYTOKINE, V121, DOI 10.1016/j.cyto.2019.154735
   Gorini S, 2018, BIOMOLECULES, V8, DOI 10.3390/biom8030096
   Guo C, 2008, CIRCULATION, V117, P2253, DOI 10.1161/CIRCULATIONAHA.107.748640
   Hayakawa T, 2018, J ENDOCRINOL, V239, P63, DOI 10.1530/JOE-18-0026
   Heylen E, 2009, J CARDIOVASC PHARM, V54, P535, DOI 10.1097/FJC.0b013e3181bfb00d
   Hirata A, 2009, CARDIOVASC RES, V84, P164, DOI 10.1093/cvr/cvp191
   Huby AC, 2015, CIRCULATION, V132, P2134, DOI 10.1161/CIRCULATIONAHA.115.018226
   Hwang MH, 2016, EXP GERONTOL, V73, P86, DOI 10.1016/j.exger.2015.11.017
   Hwang MH, 2013, CLIN SCI, V125, P513, DOI 10.1042/CS20130200
   Infante M, 2017, COMPR PHYSIOL, V7, P1425, DOI 10.1002/cphy.c160037
   Jaffe IZ, 2010, J CLIN INVEST, V120, P3891, DOI 10.1172/JCI40205
   Jaffe IZ, 2005, CIRC RES, V96, P643, DOI 10.1161/01.RES.0000159937.05502.d1
   Jia GH, 2018, HYPERTENSION, V72, P731, DOI 10.1161/HYPERTENSIONAHA.118.11339
   Jia GHH, 2017, CARDIOVASC RES, V113, P1055, DOI 10.1093/cvr/cvx097
   Jia GH, 2016, CIRC RES, V118, P935, DOI 10.1161/CIRCRESAHA.115.308269
   Karashima S, 2016, HYPERTENS RES, V39, P133, DOI 10.1038/hr.2015.129
   Keidar S, 2003, J CARDIOVASC PHARM, V41, P955, DOI 10.1097/00005344-200306000-00019
   Kolkhof P, 2014, J CARDIOVASC PHARM, V64, P69, DOI 10.1097/FJC.0000000000000091
   Lainscak M, 2015, INT J CARDIOL, V200, P25, DOI 10.1016/j.ijcard.2015.05.127
   Le Billan F, 2018, FASEB J, V32, P5626, DOI 10.1096/fj.201800391RR
   Lefranc C, 2019, HYPERTENSION, V73, P458, DOI 10.1161/HYPERTENSIONAHA.118.11873
   Lincoln TM, 2007, CIRC RES, V100, P10, DOI 10.1161/01.RES.0000255894.25293.82
   Loh RKC, 2017, OBES REV, V18, P1227, DOI 10.1111/obr.12584
   Mammi C, 2016, INT J OBESITY, V40, P964, DOI 10.1038/ijo.2016.13
   Maron BA, 2009, J BIOL CHEM, V284, P7665, DOI 10.1074/jbc.M809460200
   Marzolla V, 2017, INT J CARDIOL, V232, P233, DOI 10.1016/j.ijcard.2017.01.013
   Marzolla V, 2014, STEROIDS, V91, P46, DOI 10.1016/j.steroids.2014.05.001
   McCurley A, 2012, NAT MED, V18, P1429, DOI 10.1038/nm.2891
   McCurley A, 2012, MOL CELL ENDOCRINOL, V350, P256, DOI 10.1016/j.mce.2011.06.014
   McGraw AP, 2013, J AM HEART ASSOC, V2, DOI 10.1161/JAHA.112.000018
   Mohandas A, 2015, VASC MED, V20, P401, DOI 10.1177/1358863X15584753
   Mueller KB, 2015, HYPERTENSION, V66, P988, DOI 10.1161/HYPERTENSIONAHA.115.06172
   Mutoh A, 2008, HYPERTENS RES, V31, P1811, DOI 10.1291/hypres.31.1811
   Nagata D, 2006, HYPERTENSION, V48, P165, DOI 10.1161/01.HYP.0000226054.53527.bb
   Nakamura K, 2014, J CARDIOL, V63, P250, DOI 10.1016/j.jjcc.2013.11.006
   Newfell BG, 2011, ARTERIOSCL THROM VAS, V31, P1871, DOI 10.1161/ATVBAHA.111.229070
   Nietlispach F, 2007, HYPERTENSION, V50, P82, DOI 10.1161/HYPERTENSIONAHA.107.088955
   Palombo C, 2016, VASC PHARMACOL, V77, P1, DOI 10.1016/j.vph.2015.11.083
   Raz-Pasteur A, 2012, J CARDIOVASC PHARM, V60, P508, DOI 10.1097/FJC.0b013e31826f5535
   RONDINONE CM, 1993, ENDOCRINOLOGY, V132, P2421, DOI 10.1210/en.132.6.2421
   Ruhs S, 2017, J ENDOCRINOL, V234, pT107, DOI 10.1530/JOE-16-0659
   Schäfer N, 2013, EUR HEART J, V34, P3515, DOI 10.1093/eurheartj/eht095
   Schmidt BMW, 1999, J CLIN ENDOCR METAB, V84, P3528, DOI 10.1210/jc.84.10.3528
   Singh R, 2009, J CLIN INVEST, V119, P3329, DOI 10.1172/JCI39228
   Srinivasa S, 2018, J CLIN ENDOCR METAB, V103, P2376, DOI 10.1210/jc.2018-00330
   Stern JH, 2016, CELL METAB, V23, P770, DOI 10.1016/j.cmet.2016.04.011
   Strasser B, 2015, NUTR METAB CARDIOVAS, V25, P495, DOI 10.1016/j.numecd.2015.01.002
   Thuzar M, 2019, DIABETES OBES METAB, V21, P509, DOI 10.1111/dom.13539
   Urbanet R, 2015, HYPERTENSION, V66, P149, DOI 10.1161/HYPERTENSIONAHA.114.04981
   Verhoeven F, 2016, ARTHRITIS RES THER, V18, DOI 10.1186/s13075-016-1157-0
   Viengchareun S, 2001, AM J PHYSIOL-ENDOC M, V280, pE640, DOI 10.1152/ajpendo.2001.280.4.E640
   Villacorta L, 2015, HORM MOL BIOL CLIN I, V21, P137, DOI 10.1515/hmbci-2014-0048
   Virtue S, 2012, DIABETES, V61, P3139, DOI 10.2337/db12-0015
   Wang BX, 2014, CURR DIABETES REV, V10, P131, DOI 10.2174/1573399810666140508121012
   Wang QA, 2014, J LIPID RES, V55, P605, DOI 10.1194/jlr.R046441
   Yoneshiro T, 2013, J CLIN INVEST, V123, P3404, DOI 10.1172/JCI67803
   Zennaro MC, 2009, TRENDS ENDOCRIN MET, V20, P444, DOI 10.1016/j.tem.2009.05.006
   Zhang YM, 2018, NAT REV ENDOCRINOL, V14, P356, DOI 10.1038/s41574-018-0009-1
NR 104
TC 54
Z9 54
U1 0
U2 5
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD MAR
PY 2020
VL 31
IS 3
BP 205
EP 217
DI 10.1016/j.tem.2019.11.006
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA KN4PR
UT WOS:000514821100003
PM 31843490
DA 2025-06-11
ER

PT S
AU Mahdavi, A
   Bagherniya, M
   Mirenayat, MS
   Atkin, SL
   Sahebkar, A
AF Mahdavi, Atena
   Bagherniya, Mohammad
   Mirenayat, Mohammad Sadegh
   Atkin, Stephen L.
   Sahebkar, Amirhossein
BE Barreto, GE
   Sahebkar, A
TI Medicinal Plants and Phytochemicals Regulating Insulin Resistance and
   Glucose Homeostasis in Type 2 Diabetic Patients: A Clinical Review
SO PHARMACOLOGICAL PROPERTIES OF PLANT-DERIVED NATURAL PRODUCTS AND
   IMPLICATIONS FOR HUMAN HEALTH
SE Advances in Experimental Medicine and Biology
LA English
DT Review; Book Chapter
DE Type 2 diabetes; Metabolic syndrome; Insulin resistance; Medicinal
   plants
ID CARDIOVASCULAR RISK-FACTORS; IMPROVES GLYCEMIC CONTROL; RANDOMIZED
   DOUBLE-BLIND; FASTING PLASMA-INSULIN; GREEN TEA CONSUMPTION; FATTY
   LIVER-DISEASE; OXIDATIVE STRESS; HEALTH-BENEFITS; RESVERATROL
   SUPPLEMENTATION; METABOLIC SYNDROME
AB Diabetes is a major health problem affecting more than four hundred million adults worldwide. The transition from normal glucose tolerance to type 2 diabetes (T2D) is preceded by increased Insulin resistance (IR), an independent predictor of the development of T2D in high risk (e.g. obese populations, pre-diabetes) individuals. Insulin deficiency resulting from increased IR results in progressive glucose homeostasis dysfunction. Data has shown that IR is affected by many different factors such as genetics, age, exercise, dietary nutrients, obesity, and body fat distribution. One of the most important factors is diet, which plays an essential role in addressing T2D and metabolic syndrome. Nutraceuticals and medicinal plants have been shown to have efficacy in preventing chronic diseases like cancer, non-alcoholic fatty liver disease (NAFLD), cardiovascular disease, diabetes mellitus and metabolic syndrome, likely through the anti-inflammatory properties found in nutraceuticals. However, the effect of these compounds, including traditional plant medicines, herbal formulations or their extracts on IR have not been systematically investigated. The objective of this review was to assess the reported effects of medicinal plants and bioactive natural compounds on IR. The findings confirm that most of the herbal bioactive compounds including resveratrol, garlic, curcumin, cinnamon, ginger, nuts, berberine, anthocyanin, soybean, flaxseed, vegetable oils, and soluble fibers have benefit in their efficacy for decreasing IR, fasting blood sugar (FBS), fasting insulin and HbA1c.
C1 [Mahdavi, Atena; Bagherniya, Mohammad] Isfahan Univ Med Sci, Food Secur Res Ctr, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
   [Mirenayat, Mohammad Sadegh] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Students Res Comm, Esfahan, Iran.
   [Atkin, Stephen L.] Weill Cornell Med Qatar, Doha, Qatar.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Polish Mothers Mem Hosp Res Inst PMMHRI, Lodz, Poland.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Qatar Foundation (QF); Weill Cornell Medical College Qatar;
   Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Razavi Khorasan, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Razavi Khorasan, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran.; Sahebkar, A (corresponding author), Polish Mothers Mem Hosp Res Inst PMMHRI, Lodz, Poland.
EM sahebkara@mums.ac.ir
RI Sahebkar, Amirhossein/B-5124-2018; Atkin, stephen/ABE-7047-2020
CR Aamir K, 2020, PHARMACOL RES, V152, DOI 10.1016/j.phrs.2019.104602
   Abdallah M, 2018, GREEN CHEM LETT REV, V11, P189, DOI 10.1080/17518253.2018.1458161
   Abebe W, 2019, EPMA J, V10, DOI 10.1007/s13167-018-0158-2
   Aboelhadid SM, 2019, LIVEST SCI, V221, P33, DOI 10.1016/j.livsci.2019.01.011
   Aborehab NM, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-2002-y
   Abutair AS, 2016, NUTR J, V15, DOI 10.1186/s12937-016-0207-4
   Adeghate E, 2014, HEART FAIL REV, V19, P15, DOI 10.1007/s10741-013-9388-5
   Ahn HY, 2018, NUTR DIABETES, V8, DOI 10.1038/s41387-018-0052-y
   Akilen R, 2010, DIABETIC MED, V27, P1159, DOI 10.1111/j.1464-5491.2010.03079.x
   Ali BH, 2008, FOOD CHEM TOXICOL, V46, P409, DOI 10.1016/j.fct.2007.09.085
   Allen RW, 2013, ANN FAM MED, V11, P452, DOI 10.1370/afm.1517
   Anderson JW, 2009, NUTR REV, V67, P188, DOI 10.1111/j.1753-4887.2009.00189.x
   Arablou T, 2014, INT J FOOD SCI NUTR, V65, P515, DOI 10.3109/09637486.2014.880671
   Arsenijevic N, SERBIAN J EXP CLIN R, V17, P35
   Asadi S, 2019, COMPLEMENT THER MED, V43, P253, DOI 10.1016/j.ctim.2019.02.014
   Atkin M, 2016, J DIABETES COMPLICAT, V30, P723, DOI 10.1016/j.jdiacomp.2016.01.003
   Babu PA, 2006, BIOINFORMATION, V1, P130, DOI 10.6026/97320630001130
   Bagherniya M, 2018, PHARMACOL RES, V130, P213, DOI 10.1016/j.phrs.2017.12.020
   Banach M, 2018, J AM COLL CARDIOL, V72, P96, DOI 10.1016/j.jacc.2018.04.040
   Banihani SA, 2014, NUTR RES, V34, P862, DOI 10.1016/j.nutres.2014.08.003
   Barroso I, 1999, NATURE, V402, P880, DOI 10.1038/47254
   Batlle D, 2020, CLIN SCI, V134, P543, DOI 10.1042/CS20200163
   BEARD JC, 1987, J CLIN ENDOCR METAB, V65, P59, DOI 10.1210/jcem-65-1-59
   Bhatt JK, 2012, NUTR RES, V32, P537, DOI 10.1016/j.nutres.2012.06.003
   Bo S, 2016, PHARMACOL RES, V111, P896, DOI 10.1016/j.phrs.2016.08.010
   Borek C, 2001, J NUTR, V131, p1010S, DOI 10.1093/jn/131.3.1010S
   Brasnyó P, 2011, BRIT J NUTR, V106, P383, DOI 10.1017/S0007114511000316
   Brant LHC, 2012, ACTA CIR BRAS, V27, P537, DOI 10.1590/S0102-86502012000800004
   Chatterjee S, 2017, LANCET, V389, P2239, DOI 10.1016/S0140-6736(17)30058-2
   Chen L, 2012, NAT REV ENDOCRINOL, V8, P228, DOI 10.1038/nrendo.2011.183
   CHEN M, 1988, J CLIN ENDOCR METAB, V67, P951, DOI 10.1210/jcem-67-5-951
   CHEN M, 1987, J AM GERIATR SOC, V35, P417, DOI 10.1111/j.1532-5415.1987.tb04663.x
   CHEN M, 1985, J CLIN ENDOCR METAB, V60, P13, DOI 10.1210/jcem-60-1-13
   Cnop M, 2002, DIABETES, V51, P1005, DOI 10.2337/diabetes.51.4.1005
   Crawford P, 2009, J AM BOARD FAM MED, V22, P507, DOI 10.3122/jabfm.2009.05.080093
   Dall'Alba V, 2013, BRIT J NUTR, V110, P1601, DOI 10.1017/S0007114513001025
   Davì G, 2010, CARDIOVASC THER, V28, P216, DOI 10.1111/j.1755-5922.2010.00179.x
   DEFRONZO RA, 1979, DIABETES, V28, P1095, DOI 10.2337/diab.28.12.1095
   Del Gobbo LC, 2015, AM J CLIN NUTR, V102, P1347, DOI 10.3945/ajcn.115.110965
   Derosa G, 2014, ARCH MED SCI, V10, P336, DOI 10.5114/aoms.2014.42587
   Diab M, 2019, PRIM CARE DIABETES, V13, P197, DOI 10.1016/j.pcd.2018.11.014
   Feuerer M, 2009, NAT MED, V15, P930, DOI 10.1038/nm.2002
   Foster M, 2014, J TRACE ELEM MED BIO, V28, P448, DOI 10.1016/j.jtemb.2014.07.012
   Friedman M, 2001, J AGR FOOD CHEM, V49, P1069, DOI 10.1021/jf0009246
   Fukino Y, 2005, J NUTR SCI VITAMINOL, V51, P335, DOI 10.3177/jnsv.51.335
   Fukumitsu S, 2010, NUTR RES, V30, P441, DOI 10.1016/j.nutres.2010.06.004
   Ghandadi M, 2017, CURR PHARM DESIGN, V23, P921, DOI 10.2174/1381612822666161006151605
   Ghorbani A, 2019, ENDOCR METAB IMMUNE, V19, P1075, DOI 10.2174/1871530319666190206213420
   González S, 2007, DIABETES CARE, V30, P1871, DOI 10.2337/dc06-1814
   Goodpaster BH, 1999, DIABETES, V48, P839, DOI 10.2337/diabetes.48.4.839
   Jacobo-Cejudo MG, 2017, NUTRIENTS, V9, DOI 10.3390/nu9060573
   Goyal A, 2014, J FOOD SCI TECH MYS, V51, P1633, DOI 10.1007/s13197-013-1247-9
   Grzanna R, 2005, J MED FOOD, V8, P125, DOI 10.1089/jmf.2005.8.125
   Hakim IA, 2003, J NUTR, V133, p3303S, DOI 10.1093/jn/133.10.3303S
   Hardy OT, 2012, CURR OPIN ENDOCRINOL, V19, P81, DOI 10.1097/MED.0b013e3283514e13
   Hernández-Alonso P, 2014, DIABETES CARE, V37, P3098, DOI 10.2337/dc14-1431
   Hodaei H, 2019, DIABETOL METAB SYNDR, V11, DOI 10.1186/s13098-019-0437-7
   Hosseini S, 2014, J ETHNOPHARMACOL, V152, P451, DOI 10.1016/j.jep.2014.01.012
   Hsu Chung-Hua, 2011, Altern Med Rev, V16, P157
   Hutchins AM, 2013, NUTR RES, V33, P367, DOI 10.1016/j.nutres.2013.02.012
   Imai Shinjiro, 2015, Recent Pat Food Nutr Agric, V7, P75, DOI 10.2174/2212798407666150629123839
   Iranshahi M, 2010, PHYTOMEDICINE, V17, P269, DOI 10.1016/j.phymed.2009.05.020
   Isfort M, 2014, HEART FAIL REV, V19, P35, DOI 10.1007/s10741-013-9377-8
   Javid AZ, 2017, PHYTOTHER RES, V31, P108, DOI 10.1002/ptr.5737
   Jayagopal V, 2002, DIABETES CARE, V25, P1709, DOI 10.2337/diacare.25.10.1709
   Jenkins DJA, 2014, DIABETES CARE, V37, P1806, DOI 10.2337/dc13-2990
   Jia GH, 2016, NAT REV ENDOCRINOL, V12, P144, DOI 10.1038/nrendo.2015.216
   Kaczmarczyk MM, 2012, METABOLISM, V61, P1058, DOI 10.1016/j.metabol.2012.01.017
   Kahn SE, 2006, NATURE, V444, P840, DOI 10.1038/nature05482
   Kamalpour Mandieh, 2018, Journal of Dietary Supplements, V15, P507, DOI 10.1080/19390211.2017.1358791
   Khan A, 2003, DIABETES CARE, V26, P3215, DOI 10.2337/diacare.26.12.3215
   Khan N, 2008, CANCER LETT, V269, P269, DOI 10.1016/j.canlet.2008.04.014
   Kim JA, 2007, J BIOL CHEM, V282, P13736, DOI 10.1074/jbc.M609725200
   Kim JI, 2005, EUR J CLIN NUTR, V59, P456, DOI 10.1038/sj.ejcn.1602081
   Kim MS, 2011, ANN NY ACAD SCI, V1229, P140, DOI 10.1111/j.1749-6632.2011.06098.x
   Konya J, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00296
   Koo SI, 2007, J NUTR BIOCHEM, V18, P179, DOI 10.1016/j.jnutbio.2006.12.005
   Kruse M, 2015, MOL NUTR FOOD RES, V59, P507, DOI 10.1002/mnfr.201400446
   Lee HY, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-06872-y
   Lelli D, 2017, PHARMACOL RES, V115, P133, DOI 10.1016/j.phrs.2016.11.017
   Li D, 2015, J NUTR, V145, P742, DOI 10.3945/jn.114.205674
   Li SC, 2011, METABOLISM, V60, P474, DOI 10.1016/j.metabol.2010.04.009
   Lin L, 2013, NUTR REV, V71, P370, DOI 10.1111/nure.12033
   Liu CY, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0091163
   Liu K, 2014, AM J CLIN NUTR, V99, P1510, DOI 10.3945/ajcn.113.082024
   Liu Y, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/308134
   MacKenzie T, 2007, METABOLISM, V56, P1340, DOI 10.1016/j.metabol.2007.05.018
   Maddux BA, 2001, DIABETES, V50, P404, DOI 10.2337/diabetes.50.2.404
   Mahluji S, 2013, INT J FOOD SCI NUTR, V64, P682, DOI 10.3109/09637486.2013.775223
   MARTIN BC, 1992, LANCET, V340, P925, DOI 10.1016/0140-6736(92)92814-V
   Martin RCG, 2012, FOOD CHEM TOXICOL, V50, P227, DOI 10.1016/j.fct.2011.10.070
   Martín-Gallán P, 2003, FREE RADICAL BIO MED, V34, P1563, DOI 10.1016/S0891-5849(03)00185-0
   McCarty MF, 2005, MED HYPOTHESES, V64, P151, DOI 10.1016/j.mehy.2004.03.036
   Moazen S, 2013, ANN NUTR METAB, V63, P256, DOI 10.1159/000356053
   Mollazadeh H, 2019, CRIT REV FOOD SCI, V59, P89, DOI 10.1080/10408398.2017.1358139
   Momtazi AA, 2016, MOL DIAGN THER, V20, P335, DOI 10.1007/s40291-016-0202-7
   Mostad IL, 2006, AM J CLIN NUTR, V84, P540, DOI 10.1093/ajcn/84.3.540
   Movahed A, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/851267
   Mozaffari-Khosravi H, 2014, COMPLEMENT THER MED, V22, P9, DOI 10.1016/j.ctim.2013.12.017
   Mudgil D, 2013, INT J BIOL MACROMOL, V61, P1, DOI 10.1016/j.ijbiomac.2013.06.044
   Na LX, 2013, MOL NUTR FOOD RES, V57, P1569, DOI 10.1002/mnfr.201200131
   Nishikawa T, 2000, KIDNEY INT, V58, pS26, DOI 10.1046/j.1523-1755.2000.07705.x
   Nishimura S, 2009, NAT MED, V15, P914, DOI 10.1038/nm.1964
   Ogawa S, 2013, TOHOKU J EXP MED, V231, P63, DOI 10.1620/tjem.231.63
   OLEFSKY J, 1973, DIABETES, V22, P507, DOI 10.2337/diab.22.7.507
   Pan A, 2009, AM J CLIN NUTR, V90, P288, DOI 10.3945/ajcn.2009.27469
   Panahi Y, 2018, DRUG RES, V68, P403, DOI 10.1055/s-0044-101752
   Panahi Y, 2018, J CELL PHYSIOL, V233, P141, DOI 10.1002/jcp.25756
   Parham Mahmoud, 2014, Rev Diabet Stud, V11, P190, DOI 10.1900/RDS.2014.11.190
   Pendurthi UR, 2000, THROMB RES, V97, P179, DOI 10.1016/S0049-3848(99)00148-6
   Pi-Sunyer FX, 1998, OBES RES, V6, p51S
   Pirillo A, 2015, ATHEROSCLEROSIS, V243, P449, DOI 10.1016/j.atherosclerosis.2015.09.032
   PRIGEON RL, 1995, METABOLISM, V44, P1259, DOI 10.1016/0026-0495(95)90026-8
   Qin Bolin, 2010, J Diabetes Sci Technol, V4, P685
   Qin BL, 2009, J NUTR BIOCHEM, V20, P901, DOI 10.1016/j.jnutbio.2008.08.005
   Rabiei K, 2018, BMC COMPLEM ALTERN M, V18, DOI 10.1186/s12906-018-2268-8
   Reaven GM, 2008, ENDOCRIN METAB CLIN, V37, P581, DOI 10.1016/j.ecl.2008.06.005
   Ryu OH, 2006, DIABETES RES CLIN PR, V71, P356, DOI 10.1016/j.diabres.2005.08.001
   Saberi-Karimian M, 2020, COMPLEMENT THER MED, V49, DOI 10.1016/j.ctim.2020.102322
   Sadeghian M, 2021, J AFFECT DISORDERS, V278, P627, DOI 10.1016/j.jad.2020.09.091
   Sahebkar A, 2016, PAIN MED, V17, P1192, DOI 10.1093/pm/pnv024
   Sahebkar A, 2013, BIOFACTORS, V39, P197, DOI 10.1002/biof.1062
   Saiko P, 2008, MUTAT RES-REV MUTAT, V658, P68, DOI 10.1016/j.mrrev.2007.08.004
   Sakata R, 2013, INT J MOL MED, V32, P989, DOI 10.3892/ijmm.2013.1503
   Sarbolouki S, 2013, SINGAP MED J, V54, P387, DOI 10.11622/smedj.2013139
   Sathyapalan T, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-15402-9
   SCHWARTZ RS, 1991, METABOLISM, V40, P545, DOI 10.1016/0026-0495(91)90239-S
   Shakibaei M, 2009, MOL NUTR FOOD RES, V53, P115, DOI 10.1002/mnfr.200800148
   Shankar S, 2007, FRONT BIOSCI-LANDMRK, V12, P4839, DOI 10.2741/2432
   Sheng XY, 2008, PPAR RES, V2008, DOI 10.1155/2008/581348
   Shidfar Farzad, 2015, J Complement Integr Med, V12, P165, DOI 10.1515/jcim-2014-0021
   Shidfar F, 2012, IRAN J PHARM RES, V11, P643
   Shukla Y, 2007, FOOD CHEM TOXICOL, V45, P683, DOI 10.1016/j.fct.2006.11.002
   Soleimani A, 2017, CLIN NUTR, V36, P79, DOI 10.1016/j.clnu.2015.11.003
   Soleimani V, 2018, PHYTOTHER RES, V32, P985, DOI 10.1002/ptr.6054
   Soleimani Z, 2017, J DIABETES COMPLICAT, V31, P1394, DOI 10.1016/j.jdiacomp.2017.06.010
   Solomon TPJ, 2009, EUR J APPL PHYSIOL, V105, P969, DOI 10.1007/s00421-009-0986-9
   Stangl V, 2006, MOL NUTR FOOD RES, V50, P218, DOI 10.1002/mnfr.200500118
   Suleria H. A. R., 2015, Asian Pacific Journal of Tropical Disease, V5, P271, DOI 10.1016/S2222-1808(14)60782-9
   Tabák AG, 2009, LANCET, V373, P2215, DOI 10.1016/S0140-6736(09)60619-X
   Talaei B, 2017, NUTRIENTS, V9, DOI 10.3390/nu9090991
   Teymouri M, 2017, BIOFACTORS, V43, P331, DOI 10.1002/biof.1344
   Thota RN, 2019, LIPIDS HEALTH DIS, V18, DOI 10.1186/s12944-019-0967-x
   Tsai CW, 2012, BIOMEDICINE-TAIWAN, V2, P17, DOI 10.1016/j.biomed.2011.12.002
   Tsuda T, 2012, MOL NUTR FOOD RES, V56, P159, DOI 10.1002/mnfr.201100526
   Ueda M, 2008, BIOCHEM BIOPH RES CO, V377, P286, DOI 10.1016/j.bbrc.2008.09.128
   Valenti L, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/145421
   van Winkel R, 2008, BIPOLAR DISORD, V10, P342, DOI 10.1111/j.1399-5618.2007.00520.x
   Vanschoonbeek K, 2006, J NUTR, V136, P977, DOI 10.1093/jn/136.4.977
   Varvarovská J, 2003, J DIABETES COMPLICAT, V17, P7, DOI 10.1016/S1056-8727(01)00228-8
   Wang Y, 2016, J SCI FOOD AGR, V96, P2494, DOI 10.1002/jsfa.7370
   Wolfram S, 2007, J AM COLL NUTR, V26, p373S, DOI 10.1080/07315724.2007.10719626
   Yang HY, 2011, NUTRITION, V27, P943, DOI 10.1016/j.nut.2010.09.004
   Yang Q, 2005, NATURE, V436, P356, DOI 10.1038/nature03711
   Yin J, 2008, METABOLISM, V57, P712, DOI 10.1016/j.metabol.2008.01.013
   Zhang P, 1997, J BIOL CHEM, V272, P30615, DOI 10.1074/jbc.272.49.30615
   Zhang YF, 2008, J CLIN ENDOCR METAB, V93, P2559, DOI 10.1210/jc.2007-2404
   Zheng JS, 2016, MOL NUTR FOOD RES, V60, P2176, DOI 10.1002/mnfr.201600230
   Zheng Y, 2018, NAT REV ENDOCRINOL, V14, P88, DOI 10.1038/nrendo.2017.151
   Zimmet PZ, 2014, LANCET DIABETES ENDO, V2, P56, DOI 10.1016/S2213-8587(13)70112-8
NR 160
TC 28
Z9 31
U1 4
U2 42
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 0065-2598
EI 2214-8019
BN 978-3-030-64872-5; 978-3-030-64871-8
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2021
VL 1308
BP 161
EP 183
DI 10.1007/978-3-030-64872-5_13
D2 10.1007/978-3-030-64872-5
PG 23
WC Chemistry, Medicinal; Medicine, Research & Experimental; Pharmacology &
   Pharmacy
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Research & Experimental Medicine
GA BR3MG
UT WOS:000647701200013
PM 33861444
DA 2025-06-11
ER

PT J
AU Fraulob, JC
   Ogg-Diamantino, R
   Fernandes-Santos, C
   Aguila, MB
   Mandarim-de-Lacerda, CA
AF Fraulob, Julio C.
   Ogg-Diamantino, Rebeca
   Fernandes-Santos, Caroline
   Aguila, Marcia Barbosa
   Mandarim-de-Lacerda, Carlos A.
TI A Mouse Model of Metabolic Syndrome: Insulin Resistance, Fatty Liver and
   Non-Alcoholic Fatty Pancreas Disease (NAFPD) in C57BL/6 Mice Fed a High
   Fat Diet
SO JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
LA English
DT Article
DE metabolic syndrome; insulin resistance; fatty liver; non-alcoholic fatty
   pancreatic disease; high-fat diet
ID BETA-CELL; ADIPOSE-TISSUE; GLUCOSE-HOMEOSTASIS; DIABETES-MELLITUS;
   GLUCAGON; OBESITY; ADIPONECTIN; CHOLESTEROL; ASSOCIATION; STRESS
AB Diet-induced obesity in C57BL/6 mice triggers common features of human metabolic syndrome (MetS). The purpose is to assess the suitability of a diet-induced obesity model for investigating non-alcoholic fatty pancreatic disease (NAFPD), fatty liver and insulin resistance. Adult C57BL/6 mice were fed either high-fat chow (HFC, 60% fat) or standard chow (SC, 10% fat) during a 16-week period. We evaluated in both groups: hepatopancreatic injuries, pancreatic islets size, alpha and beta-cell immunodensities, intraperitoneal insulin tolerance test (IPITT) and oral glucose tolerance test (OGTT). The HFC mice displayed greater mass gain (p<0.0001) and total visceral fat pads (p<0.001). OGTT showed impairment of glucose clearance in HFC mice (p<0.0001). IPITT revealed insulin resistance in HFC mice (p<0.0001). The HFC mice showed larger pancreatic islet size and significantly greater alpha and beta-cell immunodensities than SC mice. Pancreas and liver from HFC were heavier and contained higher fat concentration. In conclusion, C57BL/6 mice fed a high-fat diet develop features of NAFPD. Insulin resistance and ectopic accumulation of hepatic fat are well known to occur in MetS. Additionally, the importance of fat accumulation in the pancreas has been recently highlighted. Therefore, this model could help to elucidate target organ alterations associated with metabolic syndrome.
C1 [Fraulob, Julio C.; Ogg-Diamantino, Rebeca; Fernandes-Santos, Caroline; Aguila, Marcia Barbosa; Mandarim-de-Lacerda, Carlos A.] Univ Estado Rio De Janeiro, Lab Morphometry & Cardiovasc Morphol, Biomed Ctr, Inst Biol, BR-20551030 Rio De Janeiro, Brazil.
C3 Universidade do Estado do Rio de Janeiro
RP Mandarim-de-Lacerda, CA (corresponding author), Univ Estado Rio De Janeiro, Lab Morphometry & Cardiovasc Morphol, Biomed Ctr, Inst Biol, 28 Setembro,87 Fds, BR-20551030 Rio De Janeiro, Brazil.
EM mandarim@uerj.br
RI AQUINO, JULIO/ABG-8977-2020; Mandarim-de-Lacerda, Carlos/F-7125-2012;
   Aguila, Marcia/P-2349-2019; Mandarim-de-Lacerda, Carlos/P-2360-2019;
   Fernandes-Santos, Caroline/M-1794-2019
OI Mandarim-de-Lacerda, Carlos/0000-0003-4134-7978; Fernandes-Santos,
   Caroline/0000-0002-2420-3836; Barbosa Aguila, Marcia/0000-0003-3994-4589
FU CNPq (Brazilian Council of Science and Technology); FAPERJ (Rio de
   Janeiro State Foundation for Scientific Research)
FX This work was supported by the agencies CNPq (Brazilian Council of
   Science and Technology, www.cnpq.br) and FAPERJ (Rio de Janeiro State
   Foundation for Scientific Research, www.faperj.br).
CR Adeghate E, 2006, ANN NY ACAD SCI, V1084, P361, DOI 10.1196/annals.1372.002
   Ahima RS, 2006, OBESITY, V14, P242, DOI 10.1038/oby.2006.317
   Ahrén B, 2005, DIABETES OBES METAB, V7, P2, DOI 10.1111/j.1463-1326.2004.00361.x
   Akagiri S, 2008, J CLIN BIOCHEM NUTR, V42, P150, DOI 10.3164/jcbn.2008022
   Asghar Z, 2006, DIABETOLOGIA, V49, P90, DOI 10.1007/s00125-005-0045-y
   Bock T, 2005, DIABETES, V54, P133, DOI 10.2337/diabetes.54.1.133
   BONNEVIENIELSEN V, 1982, DIABETES METAB, V8, P271
   Bonora E, 2006, ANN MED, V38, P64, DOI 10.1080/07853890500401234
   Bueno AA, 2008, PFLUG ARCH EUR J PHY, V455, P701, DOI 10.1007/s00424-007-0330-3
   Buettner R, 2007, OBESITY, V15, P798, DOI 10.1038/oby.2007.608
   Cantley J, 2007, DIABETOLOGIA, V50, P1248, DOI 10.1007/s00125-007-0637-9
   Chitturi S, 2002, HEPATOLOGY, V35, P373, DOI 10.1053/jhep.2002.30692
   Chowdhury P, 2000, P SOC EXP BIOL MED, V223, P310, DOI 10.1046/j.1525-1373.2000.22344.x
   Dalm S, 2005, NEUROENDOCRINOLOGY, V81, P372, DOI 10.1159/000089555
   de Wilde J, 2008, PHYSIOL GENOMICS, V32, P360, DOI 10.1152/physiolgenomics.00219.2007
   den Boer M, 2004, ARTERIOSCL THROM VAS, V24, P644, DOI 10.1161/01.ATV.0000116217.57583.6e
   Fernandes-Santos C, 2009, PANCREAS, V38, pE80, DOI 10.1097/MPA.0b013e3181987d9d
   Ferrannini E, 2007, DIABETOLOGIA, V50, P2342, DOI 10.1007/s00125-007-0806-x
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Fukuyama N, 2008, J CLIN BIOCHEM NUTR, V43, P1, DOI 10.3164/jcbn.2008036
   Gallou-Kabani C, 2007, OBESITY, V15, P1996, DOI 10.1038/oby.2007.238
   Gazzaruso C, 2006, AM J CARDIOL, V97, P236, DOI 10.1016/j.amjcard.2005.07.133
   Gentile CL, 2008, J NUTR BIOCHEM, V19, P567, DOI 10.1016/j.jnutbio.2007.10.001
   Gil-Campos M, 2004, CLIN NUTR, V23, P963, DOI 10.1016/j.clnu.2004.04.010
   Hanley AJG, 2005, DIABETES, V54, P3140, DOI 10.2337/diabetes.54.11.3140
   Jiang Joy, 2008, Metabolic Syndrome and Related Disorders, V6, P1, DOI 10.1089/met.2007.0026
   Kotronen A, 2008, ARTERIOSCL THROM VAS, V28, P27, DOI 10.1161/ATVBAHA.107.147538
   Kyrou I, 2007, HORM METAB RES, V39, P430, DOI 10.1055/s-2007-981462
   Lautamäki R, 2006, AM J PHYSIOL-ENDOC M, V291, pE282, DOI 10.1152/ajpendo.00604.2005
   Lee JS, 2009, WORLD J GASTROENTERO, V15, P1869, DOI 10.3748/wjg.15.1869
   LEE Y, 1994, P NATL ACAD SCI USA, V91, P10878, DOI 10.1073/pnas.91.23.10878
   LEITER EH, 1988, FASEB J, V2, P2807, DOI 10.1096/fasebj.2.12.3044905
   Machado M, 2006, CURR OPIN CLIN NUTR, V9, P637, DOI 10.1097/01.mco.0000241677.40170.17
   Mandarim-De-Lacerda CA, 2003, AN ACAD BRAS CIENC, V75, P469, DOI 10.1590/S0001-37652003000400006
   Mathur Abhishek, 2007, HPB (Oxford), V9, P312, DOI 10.1080/13651820701504157
   Nascimento FAM, 2010, EXP TOXICOL PATHOL, V62, P17, DOI 10.1016/j.etp.2008.12.008
   Pessayre D, 2007, J GASTROEN HEPATOL, V22, pS20, DOI 10.1111/j.1440-1746.2006.04640.x
   REEVES PG, 1993, J NUTR, V123, P1939, DOI 10.1093/jn/123.11.1939
   Strissel KJ, 2007, DIABETES, V56, P2910, DOI 10.2337/db07-0767
   Tannenbaum BM, 1997, AM J PHYSIOL-ENDOC M, V273, pE1168, DOI 10.1152/ajpendo.1997.273.6.E1168
   Tipoe GL, 2009, HISTOL HISTOPATHOL, V24, P1161, DOI 10.14670/HH-24.1161
   Vogeser M, 2007, CLIN BIOCHEM, V40, P964, DOI 10.1016/j.clinbiochem.2007.05.009
   Walz HA, 2006, J ENDOCRINOL, V189, P629, DOI 10.1677/joe.1.06522
   Weir GC, 2007, J CLIN INVEST, V117, P81, DOI 10.1172/JCI30862
   Winzell MS, 2007, DIABETOLOGIA, V50, P1453, DOI 10.1007/s00125-007-0675-3
   Woods SC, 2006, PHILOS T R SOC B, V361, P1219, DOI 10.1098/rstb.2006.1858
   Yamauchi T, 2001, NAT MED, V7, P941, DOI 10.1038/90984
   Yan MX, 2006, BIOCHEM BIOPH RES CO, V347, P192, DOI 10.1016/j.bbrc.2006.06.063
   YIN FCP, 1982, AM J PHYSIOL, V243, pH941, DOI 10.1152/ajpheart.1982.243.6.H941
   Yoshikawa H, 2001, METABOLISM, V50, P613, DOI 10.1053/meta.2001.22565
   Zhang N, 2008, J SEP SCI, V31, P38, DOI 10.1002/jssc.200700341
   Zheng SQ, 2008, EUR J PHARMACOL, V584, P118, DOI 10.1016/j.ejphar.2008.01.045
NR 52
TC 351
Z9 392
U1 0
U2 45
PU JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
PI KYOTO
PA KYOTO PREFECTURAL UNIV MED, GRAD SCH MEDICAL SCIENCE, DEPT MOLECULAR
   GASTROENTEROLOGY & HEPATOLOGY, KYOTO, 602-8566, JAPAN
SN 0912-0009
EI 1880-5086
J9 J CLIN BIOCHEM NUTR
JI J. Clin. Biochem. Nutr.
PD MAY
PY 2010
VL 46
IS 3
BP 212
EP 223
DI 10.3164/jcbn.09-83
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 612MS
UT WOS:000278903500004
PM 20490316
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Althoff, M
   Holguin, F
AF Althoff, Meghan
   Holguin, Fernando
TI Contemporary management techniques of asthma in obese patients
SO EXPERT REVIEW OF RESPIRATORY MEDICINE
LA English
DT Review
DE Asthma; obesity; treatment; oxidative stress; diet
ID BODY-MASS INDEX; QUALITY-OF-LIFE; C-REACTIVE PROTEIN; FACTOR-KAPPA-B;
   WEIGHT-LOSS; BARIATRIC SURGERY; AIRWAY INFLAMMATION; METABOLIC SYNDROME;
   LUNG-FUNCTION; SYSTEMIC INFLAMMATION
AB Introduction: Obesity-associated asthma represents a heterogeneous group of clinical phenotypes, including an adult-onset phenotype. These patients often have difficult to control symptoms and often are less likely to respond to conventional asthma therapies. Areas covered: This review covers the effects of lifestyle interventions, including diet and weight loss, effect asthma outcomes and how obesity-associated asthma responds to conventional approaches to asthma management. Expert opinion: Management of obesity-associated asthma should include lifestyle modifications aimed at weight reduction, management of other co-morbidities, and limiting systemic steroids. As many of these patients have non-Th2 asthma, long-acting muscarinic antagonists and macrolides may be potentially helpful. Medications to treat metabolic syndrome.
C1 [Althoff, Meghan; Holguin, Fernando] Univ Colorado, Pulm Sci & Crit Care, Denver, CO 80202 USA.
C3 University of Colorado System; University of Colorado Denver
RP Holguin, F (corresponding author), Univ Colorado, Pulm Sci & Crit Care, Denver, CO 80202 USA.
EM Fernando.holguin@cuanschutz.edu
FU U.S. Department of Health and Human Services, National Institutes of
   Health, National Heart, Lung, and Blood Institute [HL146542-01]
FX This paper was funded by the U.S. Department of Health and Human
   Services, National Institutes of Health, National Heart, Lung, and Blood
   Institute (HL146542-01)
CR Aaron SD, 2004, CHEST, V125, P2046, DOI 10.1378/chest.125.6.2046
   Abd El-Kader MS, 2013, AFR HEALTH SCI, V13, P682, DOI 10.4314/ahs.v13i3.23
   Luna-Pech JA, 2014, INT ARCH ALLERGY IMM, V163, P252, DOI 10.1159/000360398
   Ajani UA, 2004, J NUTR, V134, P1181, DOI 10.1093/jn/134.5.1181
   Aljada A, 2004, AM J CLIN NUTR, V79, P682
   Anderson WJ, 2012, ANN ALLERG ASTHMA IM, V108, P237, DOI 10.1016/j.anai.2011.12.006
   Avallone KM, 2013, J ASTHMA, V50, P109, DOI 10.3109/02770903.2012.759963
   Baffi CW, 2016, CHEST, V149, P1525, DOI 10.1016/j.chest.2015.12.034
   Bateman ED, 2016, J ALLERGY CLIN IMMUN, V138, P142, DOI 10.1016/j.jaci.2015.11.035
   Berthon BS, 2013, RESPIROLOGY, V18, P447, DOI 10.1111/resp.12015
   Beuther DA, 2007, AM J RESP CRIT CARE, V175, P661, DOI 10.1164/rccm.200611-1717OC
   Boulet LP, 2007, RESP MED, V101, P2240, DOI 10.1016/j.rmed.2007.06.031
   Boulet LP, 2012, RESP MED, V106, P651, DOI 10.1016/j.rmed.2011.12.012
   Brumpton BM, 2013, EUR RESPIR J, V42, P1495, DOI 10.1183/09031936.00046013
   Brusselle GG, 2013, THORAX, V68, P322, DOI 10.1136/thoraxjnl-2012-202698
   Calixto MC, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076786
   Camargo CA, 2010, J ASTHMA, V47, P76, DOI 10.3109/02770900903338494
   Chen CZ, 2017, J ASTHMA, V54, P1019, DOI 10.1080/02770903.2017.1283698
   Dias SA, 2014, EUR RESPIR J, V43, P1368, DOI 10.1183/09031936.00053413
   Dixon AE, 2006, J ASTHMA, V43, P553, DOI 10.1080/02770900600859123
   Dixon AE, 2015, RESP RES, V16, DOI 10.1186/s12931-015-0303-6
   Dixon AE, 2011, J ALLERGY CLIN IMMUN, V128, P508, DOI 10.1016/j.jaci.2011.06.009
   FitzGerald JM, 2018, LANCET RESP MED, V6, P51, DOI 10.1016/S2213-2600(17)30344-2
   Forno E, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0214730
   Forno E, 2015, J ALLERGY CLIN IMMUN, V136, P304, DOI 10.1016/j.jaci.2015.01.010
   Freitas PD, 2017, AM J RESP CRIT CARE, V195, P32, DOI [10.1164/rccm.201603-0446OC, 10.1164/rccm.201603-0446oc]
   Gibson PG, 2016, INTERN MED J, V46, P1054, DOI 10.1111/imj.13166
   Gibson PG, 2017, LANCET, V390, P659, DOI 10.1016/S0140-6736(17)31281-3
   Goleva E, 2016, J ALLER CL IMM-PRACT, V4, P357, DOI 10.1016/j.jaip.2015.11.013
   Greenwood J, 2006, NAT REV IMMUNOL, V6, P358, DOI 10.1038/nri1839
   Guerron AD, 2019, SURG ENDOSC, V33, P1967, DOI 10.1007/s00464-018-6500-x
   Hakala K, 2000, CHEST, V118, P1315, DOI 10.1378/chest.118.5.1315
   Halnes I, 2017, NUTRIENTS, V9, DOI 10.3390/nu9010057
   Hasegawa K, 2015, J ALLERGY CLIN IMMUN, V136, P288, DOI 10.1016/j.jaci.2014.12.1931
   Hewitt M, 2009, AM J RESP CELL MOL, V40, P83, DOI 10.1165/rcmb.2008-0172OC
   Hewitt S, 2014, OBES SURG, V24, P705, DOI 10.1007/s11695-013-1159-9
   Holguin F, 2010, J ASTHMA, V47, P55, DOI 10.3109/02770900903318330
   Jensen ME, 2013, CLIN EXP ALLERGY, V43, P775, DOI 10.1111/cea.12115
   Johnson JB, 2007, FREE RADICAL BIO MED, V42, P665, DOI 10.1016/j.freeradbiomed.2006.12.005
   Kantor ED, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0067833
   Kew KM, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002997.pub4
   Khurana S, 2019, J ALLER CL IMM-PRACT, V7, P2425, DOI 10.1016/j.jaip.2019.03.007
   Kim JH, 2016, ANNU REV FOOD SCI T, V7, P221, DOI 10.1146/annurev-food-041715-033028
   Lazarus SC, 2019, NEW ENGL J MED, V380, P2009, DOI 10.1056/NEJMoa1814917
   Leone N, 2009, AM J RESP CRIT CARE, V179, P509, DOI 10.1164/rccm.200807-1195OC
   Li CY, 2016, RESPIROLOGY, V21, P1210, DOI 10.1111/resp.12818
   Lombardi C, 2011, J ASTHMA, V48, P553, DOI 10.3109/02770903.2011.587581
   Lugogo N, 2018, J ALLERGY CLIN IMMUN, V141, P1096, DOI 10.1016/j.jaci.2017.04.047
   Luks V, 2013, BMC PULM MED, V13, DOI 10.1186/1471-2466-13-24
   Ma J, 2015, ANN AM THORAC SOC, V12, P1, DOI 10.1513/AnnalsATS.201406-271OC
   MacRedmond R, 2010, CLIN EXP ALLERGY, V40, P1071, DOI 10.1111/j.1365-2222.2010.03531.x
   Maniscalco M, 2017, RESP MED, V130, P69, DOI 10.1016/j.rmed.2017.06.010
   McGarry ME, 2015, CHEST, V147, P1591, DOI 10.1378/chest.14-2689
   McLoughlin R, 2019, EBIOMEDICINE, V46, P473, DOI 10.1016/j.ebiom.2019.07.048
   Moore WC, 2010, AM J RESP CRIT CARE, V181, P315, DOI 10.1164/rccm.200906-0896OC
   Nyenhuis SM, 2018, J ALLER CL IMM-PRACT, V6, P751, DOI 10.1016/j.jaip.2017.10.026
   Papaioannou AI, 2018, RESP MED, V142, P15, DOI 10.1016/j.rmed.2018.07.006
   Patel C, 2007, J CLIN ENDOCR METAB, V92, P4476, DOI 10.1210/jc.2007-0778
   Peters MC, 2016, LANCET RESP MED, V4, P574, DOI 10.1016/S2213-2600(16)30048-0
   Peters U, 2018, J ALLERGY CLIN IMMUN, V141, P1169, DOI 10.1016/j.jaci.2018.02.004
   Peters-Golden M, 2006, EUR RESPIR J, V27, P495, DOI 10.1183/09031936.06.00077205
   Rayner LH, 2019, CLIN RESPIR J, V13, P299, DOI 10.1111/crj.13011
   Reddy RC, 2011, OBES SURG, V21, P200, DOI 10.1007/s11695-010-0155-6
   Risérus U, 2002, CIRCULATION, V106, P1925, DOI 10.1161/01.CIR.0000033589.15413.48
   Scott HA, 2013, CLIN EXP ALLERGY, V43, P36, DOI 10.1111/cea.12004
   Scott HA, 2017, CURR ALLERGY ASTHM R, V17, DOI 10.1007/s11882-017-0719-9
   Scott HA, 2015, RESPIROLOGY, V20, P243, DOI 10.1111/resp.12423
   Shore SA, 2008, J APPL PHYSIOL, V105, P1127, DOI 10.1152/japplphysiol.00117.2008
   Shore SA, 2008, J ALLERGY CLIN IMMUN, V121, P1087, DOI 10.1016/j.jaci.2008.03.004
   Sideleva O, 2014, J CELL BIOCHEM, V115, P421, DOI 10.1002/jcb.24678
   Simpson JL, 2008, AM J RESP CRIT CARE, V177, P148, DOI 10.1164/rccm.200707-1134OC
   Sood Akshay, 2013, J Allergy (Cairo), V2013, P785835, DOI 10.1155/2013/785835
   Spears M, 2006, CLIN EXP ALLERGY, V36, P1494, DOI 10.1111/j.1365-2222.2006.02604.x
   Spears M, 2009, CLIN PHARMACOL THER, V86, P49, DOI 10.1038/clpt.2009.41
   Stenius-Aarniala B, 2000, BRIT MED J, V320, P827, DOI 10.1136/bmj.320.7238.827
   Sullivan PW, 2018, J ALLERGY CLIN IMMUN, V141, P110, DOI 10.1016/j.jaci.2017.04.009
   Sun JY, 2019, MOL MED REP, V19, P1817, DOI 10.3892/mmr.2019.9807
   Sutherland ER, 2008, AM J RESP CRIT CARE, V178, P682, DOI 10.1164/rccm.200801-076OC
   Sweeney J, 2016, THORAX, V71, P339, DOI 10.1136/thoraxjnl-2015-207630
   Taylor B, 2008, THORAX, V63, P14, DOI 10.1136/thx.2007.082784
   Thomson NC, 2016, THER ADV RESPIR DIS, V10, P211, DOI 10.1177/1753465816632638
   Thorburn AN, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8320
   Upala S, 2019, SURG OBES RELAT DIS, V15, P794, DOI 10.1016/j.soard.2018.12.018
   van Huisstede A, 2015, THORAX, V70, P659, DOI 10.1136/thoraxjnl-2014-206712
   Vieira RP, 2007, AM J RESP CRIT CARE, V176, P871, DOI 10.1164/rccm.200610-1567OC
   Wedzicha JA, 2016, INT J CHRONIC OBSTR, V11, P81, DOI 10.2147/COPD.S89849
   Willeboordse M, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0157158
   Winnica D, 2017, CLIN EXP ALLERGY, V47, P190, DOI 10.1111/cea.12802
   Wood LG, 2003, EUR RESPIR J, V21, P177, DOI 10.1183/09031936.03.00017003a
   Wood LG, 2019, J ALLERGY CLIN IMMUN, V143, P305, DOI 10.1016/j.jaci.2018.04.037
   Wood LG, 2017, ANN AM THORAC SOC, V14, pS332, DOI 10.1513/AnnalsATS.201702-124AW
   Wood LG, 2012, AM J CLIN NUTR, V96, P534, DOI 10.3945/ajcn.111.032623
   Wood LG, 2011, J ALLERGY CLIN IMMUN, V127, P1133, DOI 10.1016/j.jaci.2011.01.036
   Yeh KH, 2011, J ASTHMA, V48, P546, DOI 10.3109/02770903.2011.581733
   Yuan C, 2012, RESP RES, V13, DOI 10.1186/1465-9921-13-108
NR 95
TC 4
Z9 4
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1747-6348
EI 1747-6356
J9 EXPERT REV RESP MED
JI Expert Rev. Respir. Med.
PD MAR 3
PY 2020
VL 14
IS 3
BP 249
EP 257
DI 10.1080/17476348.2020.1706486
EA DEC 2019
PG 9
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA KO4VQ
UT WOS:000504197400001
PM 31852311
DA 2025-06-11
ER

PT J
AU Hoirisch-Clapauch, S
AF Hoirisch-Clapauch, Silvia
TI Mechanisms affecting brain remodeling in depression: do all roads lead
   to impaired fibrinolysis?
SO MOLECULAR PSYCHIATRY
LA English
DT Review
ID TISSUE-PLASMINOGEN-ACTIVATOR; INSULIN-RESISTANCE; INTESTINAL MICROBIOTA;
   METABOLIC SYNDROME; DOPAMINE RELEASE; GENE-EXPRESSION; MOOD DISORDERS;
   INHIBITOR GENE; DISEASE; INTERLEUKIN-6
AB Fibrinolysis occurs when plasminogen activators, such as tissue plasminogen activator (tPA), convert plasminogen to plasmin, which dissolves the fibrin clot. The proteolytic activity of tPA and plasmin is not restricted to fibrin degradation. In the extravascular space, these two proteases modify a variety of substrates other than fibrin, playing a crucial role in physiological and pathological tissue remodeling. In the brain, for example, tPA and plasmin mediate the conversion of brain-derived neurotrophic factor precursor (proBDNF) to mature brain-derived neurotrophic factor precursor (BDNF). Thus, the fibrinolytic system influences processes reported to be dysfunctional in depression, including neurogenesis, synaptic plasticity, and reward processing. The hypothesis that decreased fibrinolytic activity is an important element in the pathogenesis of depression is supported by the association between depression and increased levels of plasminogen activator inhibitor (PAI)-1, the main inhibitor of tPA. Also, various biochemical markers of depression induce PAI-1 synthesis, including hypercortisolism, hyperinsulinemia, hyperleptinemia, increased levels of cytokines, and hyperhomocysteinemia. Moreover, hypofibrinolysis provides a link between depression and emotional eating, binge eating, vegetarianism, and veganism. This paper discusses the role of reduced fibrinolytic activity in the bidirectional interplay between depression and its somatic manifestations and complications. It also reviews evidence that abnormal fibrinolysis links heterogeneous conditions associated with treatment-resistant depression. Understanding the role of hypofibrinolysis in depression may open new avenues for its treatment.
C1 [Hoirisch-Clapauch, Silvia] Minist Hlth, Hosp Fed Servidores Estado, Rio De Janeiro, Brazil.
RP Hoirisch-Clapauch, S (corresponding author), Minist Hlth, Hosp Fed Servidores Estado, Rio De Janeiro, Brazil.
EM sclapauch@gmail.com
RI Hoirisch-Clapauch, Silvia/F-3813-2018
OI Hoirisch-Clapauch, Silvia/0000-0003-2453-4915
CR Abdallah MS, 2020, NEUROTHERAPEUTICS, V17, P1897, DOI 10.1007/s13311-020-00878-7
   Alessi MC, 2006, ARTERIOSCL THROM VAS, V26, P2200, DOI 10.1161/01.ATV.0000242905.41404.68
   Almeida FB, 2020, NEUROBIOL STRESS, V12, DOI 10.1016/j.ynstr.2020.100218
   Arnold SE, 2014, NEUROBIOL DIS, V67, P79, DOI 10.1016/j.nbd.2014.03.011
   Arnoldussen IAC, 2014, EUR NEUROPSYCHOPHARM, V24, P1982, DOI 10.1016/j.euroneuro.2014.03.002
   Bahi A, 2012, EUR NEUROPSYCHOPHARM, V22, P672, DOI 10.1016/j.euroneuro.2012.01.008
   Basciano Heather, 2005, Nutr Metab (Lond), V2, P5, DOI 10.1186/1743-7075-2-5
   Beloate LN, 2019, NEURAL MECHANISMS OF ADDICTION, P247, DOI 10.1016/B978-0-12-812202-0.00017-8
   Bolton JM, 2009, J AFFECT DISORDERS, V115, P367, DOI 10.1016/j.jad.2008.10.003
   Boonen E, 2013, NEW ENGL J MED, V368, P1477, DOI 10.1056/NEJMoa1214969
   Bora E, 2012, PSYCHOL MED, V42, P671, DOI 10.1017/S0033291711001668
   Bornstein SR, 2008, TRENDS ENDOCRIN MET, V19, P175, DOI 10.1016/j.tem.2008.01.009
   Bot M, 2015, BIOL PSYCHIAT, V77, DOI 10.1016/j.biopsych.2015.10.023
   Brown ES, 2004, BIOL PSYCHIAT, V55, P1, DOI 10.1016/S0006-3223(03)00473-6
   Brymer KJ, 2019, FRONT NEUROSCI-SWITZ, V13, DOI 10.3389/fnins.2019.00098
   Çakici N, 2020, BRAIN BEHAV IMMUN, V88, P547, DOI 10.1016/j.bbi.2020.04.039
   Campbell S, 2004, AM J PSYCHIAT, V161, P598, DOI 10.1176/appi.ajp.161.4.598
   Castro MC, 2015, LIFE SCI, V137, P1, DOI 10.1016/j.lfs.2015.07.010
   Cesarman-Maus C., 2015, BRIT J HAEMATOL, V129, p307 21, DOI 10.1111/j.1365-2141.2005.05444.x1:CAS:528:DC%2BD2MXltlWnt7c%3D
   Chan MK, 2016, J PSYCHIATR RES, V83, P249, DOI 10.1016/j.jpsychires.2016.08.020
   Chireh B, 2019, PREV MED REP, V14, DOI 10.1016/j.pmedr.2019.100822
   Christian KM, 2014, ANNU REV NEUROSCI, V37, P243, DOI 10.1146/annurev-neuro-071013-014134
   Crescenzo R, 2017, FOOD NUTR RES, V61, DOI 10.1080/16546628.2017.1331657
   De Luca C, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21041539
   Del Giudice M, 2018, BRAIN BEHAV IMMUN, V70, P61, DOI 10.1016/j.bbi.2018.02.013
   Ding SL, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012191
   Domenici E, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009166
   Dong J, 2007, AM J PHYSIOL-CELL PH, V292, pC209, DOI 10.1152/ajpcell.00157.2006
   Duman RS, 2002, EUR PSYCHIAT, V17, p306S
   Eriksson P, 1998, ARTERIOSCL THROM VAS, V18, P20, DOI 10.1161/01.ATV.18.1.20
   Fang WT, 2020, J AFFECT DISORDERS, V260, P302, DOI 10.1016/j.jad.2019.09.013
   Feelders RA, 2012, EUR J ENDOCRINOL, V167, P311, DOI 10.1530/EJE-11-1095
   Fernandes N, 2021, CLIN RES CARDIOL, V110, P183, DOI 10.1007/s00392-020-01697-8
   Festa A, 1999, ARTERIOSCL THROM VAS, V19, P562, DOI 10.1161/01.ATV.19.3.562
   Fidalgo TM, 2014, J ECT, V30, P47, DOI 10.1097/YCT.0b013e31828b34d8
   Frank MG, 2019, SEMIN CELL DEV BIOL, V94, P176, DOI 10.1016/j.semcdb.2019.01.001
   Fukakusa A, 2008, J NEUROCHEM, V105, P436, DOI 10.1111/j.1471-4159.2007.05142.x
   Geiser F, 2011, PSYCHIAT CLIN NEUROS, V65, P518, DOI 10.1111/j.1440-1819.2011.02241.x
   Girard RA, 2019, EXP BRAIN RES, V237, P3419, DOI 10.1007/s00221-019-05682-0
   Gold PW, 2002, MOL PSYCHIATR, V7, P254, DOI 10.1038/sj.mp.4001032
   Graham EA, 2020, J AFFECT DISORDERS, V265, P224, DOI 10.1016/j.jad.2020.01.053
   Grillo CA, 2019, EXP NEUROL, V318, P71, DOI 10.1016/j.expneurol.2019.04.012
   Han M.H., 2019, Neurobiology of Depression, P123, DOI [DOI 10.1016/B978-0-12-813333-0.00012-3, 10.1016/B978-0-12-813333-0.00012-3]
   Hoirisch-Clapauch S., 2020, THROMB UPDATE, V1, DOI [10.1016/j.tru.2020.100004, DOI 10.1016/J.TRU.2020.100004]
   Hoirisch-Clapauch S, 2019, THROMB RES, V181, pS23, DOI 10.1016/S0049-3848(19)30362-7
   Hosaka S, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00943
   Iguacel I, 2021, NUTR REV, V79, P361, DOI 10.1093/nutrit/nuaa030
   Isidori AM, 2015, J ENDOCRINOL INVEST, V38, P103, DOI 10.1007/s40618-014-0155-9
   Ito M, 2006, MOL PHARMACOL, V70, P1720, DOI 10.1124/mol.106.022467
   Janes AC, 2018, NEUROPSYCHOPHARMACOL, V43, P2445, DOI 10.1038/s41386-018-0069-x
   Jarde A, 2016, JAMA PSYCHIAT, V73, P826, DOI 10.1001/jamapsychiatry.2016.0934
   Jiang H, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/tp.2017.43
   Jiang H, 2016, SCI REP-UK, V6, DOI 10.1038/srep28525
   Jiménez-Maldonado A, 2018, BBA-MOL BASIS DIS, V1864, P24, DOI 10.1016/j.bbadis.2017.10.012
   Jin H, 2007, BIOCHEM CELL BIOL, V85, P246, DOI 10.1139/O07-011
   Kandel DB, 2001, DRUG ALCOHOL DEPEN, V64, P233, DOI 10.1016/S0376-8716(01)00126-0
   Kappelmann N, 2018, MOL PSYCHIATR, V23, P335, DOI 10.1038/mp.2016.167
   Kessler RC, 2015, EPIDEMIOL PSYCH SCI, V24, P210, DOI 10.1017/S2045796015000189
   Ketterer C, 2011, DIABETES RES CLIN PR, V93, pS47, DOI 10.1016/S0168-8227(11)70013-4
   Knudsen JR, 2020, MOL METAB, V39, DOI 10.1016/j.molmet.2020.100998
   Kootte RS, 2017, CELL METAB, V26, P611, DOI 10.1016/j.cmet.2017.09.008
   Lahlou-Laforet K, 2006, AM J CARDIOL, V97, P1287, DOI 10.1016/j.amjcard.2005.11.062
   Lamers F, 2013, MOL PSYCHIATR, V18, P692, DOI 10.1038/mp.2012.144
   Leighton SP, 2018, MOL PSYCHIATR, V23, P48, DOI 10.1038/mp.2017.205
   Lin CE, 2019, GEN HOSP PSYCHIAT, V61, P34, DOI 10.1016/j.genhosppsych.2019.10.003
   Lu B, 2005, NAT REV NEUROSCI, V6, P603, DOI 10.1038/nrn1726
   Lustig RH, 2010, J AM DIET ASSOC, V110, P1307, DOI 10.1016/j.jada.2010.06.008
   Magariños AM, 2006, P NATL ACAD SCI USA, V103, P18775, DOI 10.1073/pnas.0608785103
   Magnusson KR, 2015, NEUROSCIENCE, V300, P128, DOI 10.1016/j.neuroscience.2015.05.016
   Malemud CJ, 2006, FRONT BIOSCI-LANDMRK, V11, P1696, DOI 10.2741/1915
   Mannan M, 2016, ASIAN J PSYCHIATR, V21, P51, DOI 10.1016/j.ajp.2015.12.008
   MASTORAKOS G, 1993, J CLIN ENDOCR METAB, V77, P1690, DOI 10.1210/jc.77.6.1690
   Matys T, 2003, NAT MED, V9, P371, DOI 10.1038/nm0403-371
   May HT, 2017, EUR HEART J, V3, P296, DOI 10.1093/ehjqcco/qcx017
   McEwen BS, 2015, NAT NEUROSCI, V18, P1353, DOI 10.1038/nn.4086
   McEwen BS, 2004, EUR J PHARMACOL, V490, P13, DOI 10.1016/j.ejphar.2004.02.041
   Meijer A, 2011, GEN HOSP PSYCHIAT, V33, P203, DOI 10.1016/j.genhosppsych.2011.02.007
   Meroni M, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20184568
   Messaoudi M, 2011, BRIT J NUTR, V105, P755, DOI 10.1017/S0007114510004319
   Meyyappan AC, 2020, BMC PSYCHIATRY, V20, DOI 10.1186/s12888-020-02654-5
   Midorikawa S, 2000, BIOCHEM BIOPH RES CO, V272, P182, DOI 10.1006/bbrc.2000.2753
   Miller AH, 2016, NAT REV IMMUNOL, V16, P22, DOI 10.1038/nri.2015.5
   Moradi F, 2021, EUR J CLIN INVEST, V51, DOI 10.1111/eci.13486
   Nielsen J, 2010, AM J PHYSIOL-ENDOC M, V298, pE706, DOI 10.1152/ajpendo.00692.2009
   Nordt TK, 2001, DIABETOLOGIA, V44, P1121, DOI 10.1007/s001250100618
   NORRIS JG, 1993, J NEUROIMMUNOL, V45, P137
   Paans NPG, 2018, J PSYCHIATR RES, V97, P38, DOI 10.1016/j.jpsychires.2017.11.003
   Pandey M, 2005, FASEB J, V19, P1317, DOI 10.1096/fj.04-3459fje
   Parmer R J., 2020, J NEUROL DISORD STRO, V7, P1153
   Patel A, 2013, PSYCHIAT DANUB, V25, pS216
   Pérez-Pérez A, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21165887
   Petersen MC, 2018, PHYSIOL REV, V98, P2133, DOI 10.1152/physrev.00063.2017
   Pilon G, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015912
   Pirl WF, 2002, PSYCHO-ONCOLOGY, V11, P518, DOI 10.1002/pon.592
   Sartori CR, 2011, NEUROSCIENCE, V180, P9, DOI 10.1016/j.neuroscience.2011.02.055
   SAWDEY M, 1989, J BIOL CHEM, V264, P10396
   Scheller J, 2011, BBA-MOL CELL RES, V1813, P878, DOI 10.1016/j.bbamcr.2011.01.034
   Scherer T, 2011, REV ENDOCR METAB DIS, V12, P235, DOI 10.1007/s11154-011-9190-4
   Schoenfeld TJ, 2015, NEUROPSYCHOPHARMACOL, V40, P113, DOI 10.1038/npp.2014.230
   Segawa M, 2013, INT J NEUROPSYCHOPH, V16, P339, DOI 10.1017/S1461145712000053
   Silva DA, 2020, OBES REV, V21, DOI 10.1111/obr.12966
   Singh P, 2010, BIOCHEM BIOPH RES CO, V392, P47, DOI 10.1016/j.bbrc.2009.12.158
   Sondergaard SR, 2000, EUR J APPL PHYSIOL, V83, P95, DOI 10.1007/s004210000257
   Stahl SM, 2000, BIOL PSYCHIAT, V48, P894, DOI 10.1016/S0006-3223(00)00957-4
   Sugimoto K, 2018, TRANSL PSYCHIAT, V8, DOI 10.1038/s41398-018-0174-y
   Sylow L, 2017, NAT REV ENDOCRINOL, V13, P133, DOI 10.1038/nrendo.2016.162
   Tang BL, 2008, BIOCHEM BIOPH RES CO, V368, P181, DOI 10.1016/j.bbrc.2008.01.063
   Thorens B, 2010, AM J PHYSIOL-ENDOC M, V298, pE141, DOI 10.1152/ajpendo.00712.2009
   Tilg H, 2000, NEW ENGL J MED, V343, P1467, DOI 10.1056/NEJM200011163432007
   Trotter JH, 2014, NEUROSCIENCE, V274, P299, DOI 10.1016/j.neuroscience.2014.05.046
   Tryon M. S., 2011, CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources, V6, P1, DOI 10.1079/PAVSNNR20116034
   van Loon LJC, 2006, PFLUG ARCH EUR J PHY, V451, P606, DOI 10.1007/s00424-005-1509-0
   VanLandingham JW, 2008, J CEREBR BLOOD F MET, V28, P1786, DOI 10.1038/jcbfm.2008.73
   VANZONNEVELD AJ, 1988, P NATL ACAD SCI USA, V85, P5525
   Vaughan DE, 2005, J THROMB HAEMOST, V3, P1879, DOI 10.1111/j.1538-7836.2005.01420.x
   Visentin C, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21093235
   von Känel R, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0125858
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Walther A, 2019, JAMA PSYCHIAT, V76, P31, DOI 10.1001/jamapsychiatry.2018.2734
   Walther A, 2017, FRONT PSYCHIATRY, V7, DOI 10.3389/fpsyt.2016.00206
   Wang F, 2019, DIABETIC MED, V36, P961, DOI 10.1111/dme.14042
   Wang YX, 2021, HEALTH QUAL LIFE OUT, V19, DOI 10.1186/s12955-021-01703-1
   Wieërs G, 2020, FRONT CELL INFECT MI, V9, DOI 10.3389/fcimb.2019.00454
   Woldeyohannes HO, 2016, OBES RES CLIN PRACT, V10, P531, DOI 10.1016/j.orcp.2015.10.002
   Wright KP, 2015, BRAIN BEHAV IMMUN, V47, P24, DOI 10.1016/j.bbi.2015.01.004
   Wu QP, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000002707
   Wurtman J, 2018, CURR OBES REP, V7, P1, DOI 10.1007/s13679-017-0291-6
   Wurtman JJ, 2015, J CLIN PSYCHIAT, V76, pE1619, DOI 10.4088/JCP.15com10380
   Zhang F, 2018, PSYCHIAT RES, V269, P646, DOI 10.1016/j.psychres.2018.08.075
   Zhang FF, 2018, CNS NEUROSCI THER, V24, P994, DOI 10.1111/cns.12835
NR 130
TC 20
Z9 21
U1 0
U2 10
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD JAN
PY 2022
VL 27
IS 1
BP 525
EP 533
DI 10.1038/s41380-021-01264-1
EA AUG 2021
PG 9
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA 0K0HD
UT WOS:000685717900001
PM 34404914
DA 2025-06-11
ER

PT J
AU Esmaeelpanah, E
   Razavi, BM
   Hosseinzadeh, H
AF Esmaeelpanah, Elahe
   Razavi, Bibi Marjan
   Hosseinzadeh, Hossein
TI Green tea and metabolic syndrome: A 10-year research update review
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Review
DE Diabetes; Dyslipidemia; Green tea; Hypertension; Metabolic syndrome;
   Obesity
ID REDUCES BLOOD-PRESSURE; DIET-INDUCED OBESITY; (-)-EPIGALLOCATECHIN
   GALLATE EGCG; AMELIORATES INSULIN-RESISTANCE; DECREASES OXIDATIVE
   STRESS; FATTY LIVER-DISEASE; EPIGALLOCATECHIN GALLATE; ADIPOSE-TISSUE;
   POLYPHENOL EPIGALLOCATECHIN-3-GALLATE; DOUBLE-BLIND
AB Metabolic syndrome (MetS) has turned into a prevalent condition that has imposed a tremendous financial strain on public health care systems. It is believed that the MetS consists of four main factors (hypertension, dyslipidemia, hyperglycemia, and obesity) and may lead to cardiovascular events. Camellia sinesis, in the form of green tea (GT), is one of the most consuming beverages worldwide. Catechins are the dominant component of green tea leaves. Epigallocatechin gallate has the maximum potency. GT has been widely used as a supplement in various health conditions. As the oxidative stress pathway is one of the probable mechanisms of MetS etiologies and GT beneficial effects, GT may be a novel strategy to overcome the MetS. This review aims to reveal the probable pharmacological effects of GT on MetS. The last 10-year original articles on MetS parameters and GT have been gathered in this review. This manuscript has summarized the probable effects of green tea and its catechins on MetS and focused on each different aspect of MetS separately, which can be used as a basis for further investigations for introducing effective compounds as a way to interfere with MetS.
   It seems that GT can reduce MetS parameters commonly via anti-inflammatory and anti-oxidative mechanisms. Further clinical trials are needed to confirm the use of GT and its constituents for the treatment of MetS.
C1 [Esmaeelpanah, Elahe; Razavi, Bibi Marjan; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.
   [Razavi, Bibi Marjan] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Targeted Drug Delivery Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.; Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran.
EM hosseinzadehh@mums.ac.ir
RI Razavi, Bibi/AAY-5636-2020; Hosseinzadeh, Hossein/F-3013-2010
CR Afzal M, 2015, INFLAMMOPHARMACOLOGY, V23, P151, DOI 10.1007/s10787-015-0236-1
   Ahmad RS, 2015, J TRANSL MED, V13, DOI 10.1186/s12967-015-0436-x
   Ahmad RS, 2013, PAK J PHARM SCI, V26, P721
   Akaberi M, 2016, PHYTOTHER RES, V30, P540, DOI 10.1002/ptr.5570
   Al-Shaeli SJ, 2017, DIABETIC MED, V34, P75
   Alappat B., 2015, Journal of Agriculture and Life Sciences, V2, P15
   André DM, 2018, INT IMMUNOPHARMACOL, V62, P212, DOI 10.1016/j.intimp.2018.06.028
   Arazi H, 2014, HIGH BLOOD PRESS CAR, V21, P213, DOI 10.1007/s40292-014-0048-1
   Balsan G, 2019, NUTR J, V18, DOI 10.1186/s12937-018-0426-y
   Bao SQ, 2014, MOL NUTR FOOD RES, V58, P677, DOI 10.1002/mnfr.201300335
   Bártíková H, 2017, POL J FOOD NUTR SCI, V67, P233, DOI 10.1515/pjfns-2017-0004
   Basu A, 2013, NUTR RES, V33, P180, DOI 10.1016/j.nutres.2012.12.010
   Basu A, 2011, NUTRITION, V27, P206, DOI 10.1016/j.nut.2010.01.015
   Basu A, 2010, J AM COLL NUTR, V29, P31, DOI 10.1080/07315724.2010.10719814
   Bazzaz BSF, 2016, J PHARMACOPUNCT, V19, P312, DOI 10.3831/KPI.2016.19.032
   Bettaieb A, 2014, FREE RADICAL BIO MED, V72, P247, DOI 10.1016/j.freeradbiomed.2014.04.011
   Bitzer ZT, 2016, MOL NUTR FOOD RES, V60, P2267, DOI 10.1002/mnfr.201501042
   Bogdanski P, 2012, NUTR RES, V32, P421, DOI 10.1016/j.nutres.2012.05.007
   Bornhoeft J, 2012, J MED FOOD, V15, P726, DOI 10.1089/jmf.2011.0258
   Bousová I, 2016, EUR J NUTR, V55, P361, DOI 10.1007/s00394-015-0856-7
   Brown AL, 2009, BRIT J NUTR, V101, P886, DOI 10.1017/S0007114508047727
   Butt MS, 2015, CRIT REV FOOD SCI, V55, P792, DOI 10.1080/10408398.2012.680205
   Byun JK, 2014, IMMUNOL LETT, V157, P51, DOI 10.1016/j.imlet.2013.11.006
   Cai Y, 2013, PATHOG DIS, V67, P76, DOI 10.1111/2049-632X.12001
   Catanzaro DP, 2018, J CLIN PERIODONTOL, V45, P557, DOI 10.1111/jcpe.12883
   Chacko Sabu M, 2010, Chin Med, V5, P13, DOI 10.1186/1749-8546-5-13
   Chen TT, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201801064
   Chen TS, 2017, J APPL PHYSIOL, V123, P1081, DOI 10.1152/japplphysiol.00471.2016
   Chen YK, 2011, J AGR FOOD CHEM, V59, P11862, DOI 10.1021/jf2029016
   Cichello SA, 2013, MEDITERR J NUTR META, V6, P233, DOI 10.1007/s12349-013-0137-z
   Cremonini E, 2018, REDOX BIOL, V14, P588, DOI 10.1016/j.redox.2017.11.002
   Cremonini E, 2016, ARCH BIOCHEM BIOPHYS, V599, P13, DOI 10.1016/j.abb.2016.03.006
   Cunha CA, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/635470
   Dash RP, 2015, EUR J PHARMACOL, V767, P67, DOI 10.1016/j.ejphar.2015.10.009
   de Moraes BB, 2011, HEPATOL INT, V5, P965, DOI 10.1007/s12072-011-9275-x
   Dehghani S, 2019, IRAN J BASIC MED SCI, V22, P460, DOI 10.22038/IJBMS.2019.31964.7678
   Ding SB, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0181666
   Esmaeelpanah E, 2018, DRUG CHEM TOXICOL, V41, P441, DOI 10.1080/01480545.2017.1381108
   Esmaeelpanah E, 2015, JUNDISHAPUR J NAT PH, V10, DOI 10.17795/jjnpp-18406
   Fang X, 2019, NUTR RES, V70, P50, DOI 10.1016/j.nutres.2018.06.004
   Ferreira MA, 2017, CLIN NUTR ESPEN, V22, P1, DOI 10.1016/j.clnesp.2017.08.008
   Fiorino P, 2012, EXP DIABETES RES, DOI 10.1155/2012/309231
   Fu Z, 2013, J AGR FOOD CHEM, V61, P4303, DOI 10.1021/jf304915h
   Fu Z, 2011, BRIT J NUTR, V105, P1218, DOI 10.1017/S0007114510004824
   Gan L, 2015, ACTA PHARMACOL SIN, V36, P597, DOI 10.1038/aps.2015.11
   Garcia ML, 2017, J HYPERTENS, V35, P348, DOI 10.1097/HJH.0000000000001149
   Gholamreza S., 2013, Sport Science, V6, P44
   Gómez-Guzmán M, 2012, FREE RADICAL BIO MED, V52, P70, DOI 10.1016/j.freeradbiomed.2011.09.015
   Gómez-Guzmán M, 2011, BRIT J NUTR, V106, P1337, DOI 10.1017/S0007114511004314
   Grundy SM, 2016, TRENDS CARDIOVAS MED, V26, P364, DOI 10.1016/j.tcm.2015.10.004
   Guo XJ, 2017, INT J FOOD SCI TECH, V52, P1723, DOI 10.1111/ijfs.13479
   Gutiérrez-Salmeán G, 2016, INT J CARDIOL, V223, P500, DOI 10.1016/j.ijcard.2016.08.158
   Gutiérrez-Salmeán G, 2014, FOOD FUNCT, V5, P521, DOI 10.1039/c3fo60416k
   Hassani FV, 2016, N-S ARCH PHARMACOL, V389, P931, DOI 10.1007/s00210-016-1256-0
   Hininger-Favier I, 2009, J AM COLL NUTR, V28, P355, DOI 10.1080/07315724.2009.10718097
   Hong ZY, 2014, J AGR FOOD CHEM, V62, P12603, DOI 10.1021/jf504603n
   Hosseini A, 2015, J ENDOCRINOL INVEST, V38, P1147, DOI 10.1007/s40618-015-0313-8
   Hosseinzadeh H, 2014, J ENDOCRINOL INVEST, V37, P783, DOI 10.1007/s40618-014-0096-3
   Huang J, 2014, EUR J CLIN NUTR, V68, P1075, DOI 10.1038/ejcn.2014.143
   Huang JB, 2013, J AGR FOOD CHEM, V61, P8565, DOI 10.1021/jf402004x
   Huang LH, 2018, BMC COMPLEM ALTERN M, V18, DOI 10.1186/s12906-018-2355-x
   Huang SM, 2013, MOL NUTR FOOD RES, V57, P2264, DOI 10.1002/mnfr.201300275
   Jackson D, 2018, MOLECULES, V23, DOI 10.3390/molecules23071511
   Jang HJ, 2013, AM J PHYSIOL-ENDOC M, V305, pE1444, DOI 10.1152/ajpendo.00434.2013
   Jibu Thomas Jibu Thomas, 2013, International Journal of Pharma and Bio Sciences, V4, pP
   Josic J, 2010, NUTR J, V9, DOI 10.1186/1475-2891-9-63
   Jung MH, 2013, NUTR RES PRACT, V7, P366, DOI 10.4162/nrp.2013.7.5.366
   Kim E, 2016, DIABETES RES CLIN PR, V120, pS85
   Kumar B, 2012, OPHTHALMIC RES, V47, P103, DOI 10.1159/000330051
   Labdi A, 2018, MEDITERR J NUTR META, V11, P295, DOI 10.3233/MNM-180227
   Lahirin R, 2015, MED J INDONES, V24, P97, DOI 10.13181/mji.v24i2.1167
   Lee LS, 2015, MOL NUTR FOOD RES, V59, P784, DOI 10.1002/mnfr.201400470
   Levy Y, 2017, CLIN NUTR, V36, P315, DOI 10.1016/j.clnu.2016.11.001
   Li SY, 2012, J NUTR BIOCHEM, V23, P1655, DOI 10.1016/j.jnutbio.2011.11.008
   Li Y, 2011, DIABETES RES CLIN PR, V93, P205, DOI 10.1016/j.diabres.2011.03.036
   Liang YR, 2011, FOOD SCI BIOTECHNOL, V20, P93, DOI 10.1007/s10068-011-0013-x
   Litterio MC, 2015, J NUTR BIOCHEM, V26, P745, DOI 10.1016/j.jnutbio.2015.02.004
   Liu CY, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0091163
   Liu HW, 2015, J AGR FOOD CHEM, V63, P8407, DOI 10.1021/acs.jafc.5b02501
   Liu XN, 2018, INT J EPIDEMIOL, V47, P1887, DOI 10.1093/ije/dyy173
   Lombo C, 2016, INT J IMPOT RES, V28, P133, DOI 10.1038/ijir.2016.19
   Lu CW, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038332
   Lukitasari M, 2018, J HYPERTENS, V36, pE9, DOI 10.1097/01.hjh.0000544393.97442.09
   Maiti S., 2019, Clinical nutrition experimental, V24, P1, DOI [10.1016/j.yclnex.2018.12.004, DOI 10.1016/J.YCLNEX.2018.12.004]
   Martin BJ, 2016, APPL PHYSIOL NUTR ME, V41, P1057, DOI 10.1139/apnm-2016-0169
   Maruyama K, 2009, J CLIN BIOCHEM NUTR, V44, P41, DOI 10.3164/jcbn.08-13
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   Mielgo-Ayuso J, 2014, BRIT J NUTR, V111, P1263, DOI 10.1017/S0007114513003784
   Miltonprabu S, 2015, J TRACE ELEM MED BIO, V29, P321, DOI 10.1016/j.jtemb.2014.08.015
   Minatti J, 2012, NUTR RES, V32, P684, DOI 10.1016/j.nutres.2012.08.003
   Miyata Y, 2019, MOLECULES, V24, DOI 10.3390/molecules24010193
   Mohammadi S., 2010, ZUMS J, V18, P44
   Mollazadeh H, 2016, IRAN J BASIC MED SCI, V19, P1258, DOI 10.22038/ijbms.2016.7906
   Morrison M, 2014, ATHEROSCLEROSIS, V235, pE142, DOI 10.1016/j.atherosclerosis.2014.05.402
   Mortazavi F, 2019, NUTR FOOD SCI, V49, P32, DOI [10.1108/nfs-03-2018-0091, 10.1108/NFS-03-2018-0091]
   Mostafa U. E., 2014, Jordan Journal of Biological Sciences (JJBS), V7, P7
   Mousavi A, 2013, J RES MED SCI, V18, P1080
   Nabi BN, 2018, IRAN RED CRESCENT ME, V20, DOI 10.5812/ircmj.55950
   Nogueira LD, 2017, J AM COLL NUTR, V36, P108, DOI 10.1080/07315724.2016.1194236
   Nugroho DA, 2017, J HYPERTENS, V35, pE13, DOI 10.1097/01.hjh.0000527446.85651.18
   Nugroho DA, 2018, J HYPERTENS, V36, pE9, DOI 10.1097/01.hjh.0000544394.05066.dc
   Ohishi Tomokazu, 2016, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, V15, P74, DOI 10.2174/1871523015666160915154443
   Otton R, 2018, J NUTR BIOCHEM, V57, P170, DOI 10.1016/j.jnutbio.2018.03.024
   Pervin M, 2018, MOLECULES, V23, DOI 10.3390/molecules23061297
   Batista GDP, 2009, ARQ BRAS CARDIOL, V93, P121
   Qian BJ, 2018, LIFE SCI, V203, P193, DOI 10.1016/j.lfs.2018.04.041
   Qin BL, 2010, MOL NUTR FOOD RES, V54, pS14, DOI 10.1002/mnfr.200900306
   Ramachandran B, 2016, TOXICOL REP, V3, P336, DOI 10.1016/j.toxrep.2016.03.001
   Ramesh E, 2010, CHEM-BIOL INTERACT, V183, P125, DOI 10.1016/j.cbi.2009.09.013
   Ramesh E, 2009, CHEM-BIOL INTERACT, V180, P10, DOI 10.1016/j.cbi.2009.02.013
   Rameshrad M, 2017, FOOD CHEM TOXICOL, V100, P115, DOI 10.1016/j.fct.2016.11.035
   Razavi BM, 2014, J ENDOCRINOL INVEST, V37, P1031, DOI 10.1007/s40618-014-0150-1
   Razavi B. M., 2019, BIOACTIVE FOOD DIETA, DOI DOI 10.1016/B978-0-12-813822-9.00034-5
   Razavi BM, 2017, BIOMED PHARMACOTHER, V92, P726, DOI 10.1016/j.biopha.2017.05.113
   Razavi BM, 2017, J SCI FOOD AGR, V97, P1679, DOI 10.1002/jsfa.8134
   REAVEN GM, 1995, PHYSIOL REV, V75, P473, DOI 10.1152/physrev.1995.75.3.473
   Rocha A, 2016, EUR J NUTR, V55, P2231, DOI 10.1007/s00394-015-1033-8
   Roghani Mehrdad, 2010, Pathophysiology, V17, P55, DOI 10.1016/j.pathophys.2009.07.004
   Saboya PP, 2016, REV LAT-AM ENFERM, V24, DOI 10.1590/1518-8345.1573.2848
   Saeki K, 2018, MOLECULES, V23, DOI 10.3390/molecules23061295
   Sampath C, 2017, BIOMED PHARMACOTHER, V87, P73, DOI 10.1016/j.biopha.2016.12.082
   Sanati S, 2018, IRAN J BASIC MED SCI, V21, P439, DOI 10.22038/IJBMS.2018.25200.6238
   Sano T, 2017, NUTR METAB CARDIOVAS, V27, P249, DOI 10.1016/j.numecd.2016.11.008
   Seo DB, 2015, J MED FOOD, V18, P549, DOI 10.1089/jmf.2014.3265
   Shah T, 2017, J LIAQUAT UNIV MED H, V16, P200, DOI 10.22442/jlumhs.171640533
   Shakib Z, 2019, PHYTOTHER RES, V33, P2649, DOI 10.1002/ptr.6465
   Shandiz HT, 2017, PHYTOTHER RES, V31, P1173, DOI 10.1002/ptr.5862
   Sogawa M, 2009, J MED INVESTIG, V56, P42, DOI 10.2152/jmi.56.42
   Son JT, 2012, J GERONTOL NURS, V38, P30, DOI 10.3928/00989134-20120207-01
   Soori R, 2018, SPORT SCI HLTH, V14, P421
   Szulinska M, 2017, FOOD NUTR RES, V61, DOI [10.1080/16546628.2017.1295525, 10.1080/16546628.2017]
   Tabeshpour J, 2017, IRAN J BASIC MED SCI, V20, P557, DOI 10.22038/IJBMS.2017.8682
   Tabeshpour J, 2017, PHYTOTHER RES, V31, P819, DOI 10.1002/ptr.5805
   Tajmohammadi A, 2018, PHYTOTHER RES, V32, P1933, DOI 10.1002/ptr.6153
   Tehrani Hatav Gasemi, 2017, J Educ Health Promot, V6, P36, DOI 10.4103/jehp.jehp_67_15
   Thielecke F, 2010, EUR J CLIN NUTR, V64, P704, DOI 10.1038/ejcn.2010.47
   Thong J., 2016, AM J OBSTET GYNECOL, V215, pel
   Toolsee NA, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/412379
   Tsai CH, 2009, INT J FOOD SCI NUTR, V60, P151, DOI 10.1080/09637480903136667
   Ueda M, 2012, J AGR FOOD CHEM, V60, P8917, DOI 10.1021/jf2053788
   Ullah N., 2011, MED FORUM MON, V22, P46
   Senger AEV, 2012, J NUTR HEALTH AGING, V16, P738, DOI 10.1007/s12603-012-0081-5
   Wang MH, 2012, BEHAV PHARMACOL, V23, P771, DOI 10.1097/FBP.0b013e32835a3bc8
   Wang W, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00195
   Yamashita S, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-28338-5
   Yan JQ, 2013, SCI CHINA LIFE SCI, V56, P804, DOI 10.1007/s11427-013-4512-2
   Yan JQ, 2012, FREE RADICAL BIO MED, V52, P1648, DOI 10.1016/j.freeradbiomed.2012.01.033
   Yang PX, 2010, AM J OBSTET GYNECOL, V203, DOI 10.1016/j.ajog.2010.02.008
   Yi QY, 2016, TOXICOL LETT, V262, P105, DOI 10.1016/j.toxlet.2016.09.010
   Yi QY, 2016, CARDIOVASC TOXICOL, V16, P276, DOI 10.1007/s12012-015-9335-x
   Yousaf S, 2014, FOOD FUNCT, V5, P545, DOI 10.1039/c3fo60203f
   Zhan W, 2016, RSC ADV, V6, P96918, DOI 10.1039/c6ra20750b
   Zhang H, 2017, J HUM NUTR DIET, V30, P753, DOI 10.1111/jhn.12470
   Zhang XZ, 2015, J BIOMATER TISS ENG, V5, P813, DOI 10.1166/jbt.2015.1381
NR 154
TC 9
Z9 9
U1 0
U2 17
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD SEP
PY 2021
VL 24
IS 9
BP 1159
EP 1172
PG 14
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA UL3NM
UT WOS:000692562000001
PM 35083002
DA 2025-06-11
ER

PT J
AU Yanai, H
   Adachi, H
   Hakoshima, M
   Iida, S
   Katsuyama, H
AF Yanai, Hidekatsu
   Adachi, Hiroki
   Hakoshima, Mariko
   Iida, Sakura
   Katsuyama, Hisayuki
TI A Possible Therapeutic Application of the Selective Inhibitor of Urate
   Transporter 1, Dotinurad, for Metabolic Syndrome, Chronic Kidney
   Disease, and Cardiovascular Disease
SO CELLS
LA English
DT Review
DE ATP-binding cassette transporter G2; chronic kidney disease; dotinurad;
   hyperuricemia; organic anion transporter1/3; urate transporter 1
ID SERUM URIC-ACID; OXIDATIVE STRESS; RENAL-FUNCTION; ENDOTHELIAL
   DYSFUNCTION; INSULIN-RESISTANCE; HEPATIC STEATOSIS; BLOOD-PRESSURE;
   RISK-FACTOR; ALLOPURINOL; HYPERURICEMIA
AB The reabsorption of uric acid (UA) is mainly mediated by urate transporter 1 (URAT1) and glucose transporter 9 (GLUT9) in the kidneys. Dotinurad inhibits URAT1 but does not inhibit other UA transporters, such as GLUT9, ATP-binding cassette transporter G2 (ABCG2), and organic anion transporter 1/3 (OAT1/3). We found that dotinurad ameliorated the metabolic parameters and renal function in hyperuricemic patients. We consider the significance of the highly selective inhibition of URAT1 by dotinurad for metabolic syndrome, chronic kidney disease (CKD), and cardiovascular disease (CVD). The selective inhibition of URAT1 by dotinurad increases urinary UA in the proximal tubules, and this un-reabsorbed UA may compete with urinary glucose for GLUT9, reducing glucose reabsorption. The inhibition by dotinurad of UA entry via URAT1 into the liver and adipose tissues increased energy expenditure and decreased lipid synthesis and inflammation in rats. Such effects may improve metabolic parameters. CKD patients accumulate uremic toxins, including indoxyl sulfate (IS), in the body. ABCG2 regulates the renal and intestinal excretion of IS, which strongly affects CKD. OAT1/3 inhibitors suppress IS uptake into the kidneys, thereby increasing plasma IS, which produces oxidative stress and induces vascular endothelial dysfunction in CKD patients. The highly selective inhibition of URAT1 by dotinurad may be beneficial for metabolic syndrome, CKD, and CVD.
C1 [Yanai, Hidekatsu; Adachi, Hiroki; Hakoshima, Mariko; Iida, Sakura; Katsuyama, Hisayuki] Kohnodai Hosp, Natl Ctr Global Hlth & Med, Dept Diabet Endocrinol & Metab, 1-7-1 Kohnodai, Ichikawa, Chiba 2728516, Japan.
C3 Japan Institute for Health Security (JIHS); National Center for Global
   Health & Medicine - Japan
RP Yanai, H (corresponding author), Kohnodai Hosp, Natl Ctr Global Hlth & Med, Dept Diabet Endocrinol & Metab, 1-7-1 Kohnodai, Ichikawa, Chiba 2728516, Japan.
EM dyanai@hospk.ncgm.go.jp; dadachidm@hospk.ncgm.go.jp;
   d-hakoshima@hospk.ncgm.go.jp; d-20iida@hospk.ncgm.go.jp;
   d-katsuyama@hospk.ncgm.go.jp
RI Yanai, Hidekatsu/AFN-9517-2022
OI Yanai, Hidekatsu/0000-0002-4199-3665; Katsuyama,
   Hisayuki/0000-0003-2871-8340
CR Achan V, 2003, ARTERIOSCL THROM VAS, V23, P1455, DOI 10.1161/01.ATV.0000081742.92006.59
   Alem MM, 2018, CARDIOVASC THER, V36, DOI 10.1111/1755-5922.12432
   Avramoglu RK, 2006, CLIN CHIM ACTA, V368, P1, DOI 10.1016/j.cca.2005.12.026
   Baldwin W, 2011, DIABETES, V60, P1258, DOI 10.2337/db10-0916
   Barreto FC, 2009, CLIN J AM SOC NEPHRO, V4, P1551, DOI 10.2215/CJN.03980609
   Barrientos-Regala M, 2020, J CARDIOVASC PHARM, V76, P461, DOI 10.1097/FJC.0000000000000871
   BERGER L, 1975, AM J MED, V59, P605, DOI 10.1016/0002-9343(75)90222-3
   Câmara NOS, 2009, BRAZ J MED BIOL RES, V42, P229, DOI 10.1590/S0100-879X2009000300003
   Carnicelli AP, 2020, AM J MED, V133, pE716, DOI 10.1016/j.amjmed.2020.03.054
   Caulfield MJ, 2008, PLOS MED, V5, P1509, DOI 10.1371/journal.pmed.0050197
   Chen Y, 2020, J AM SOC NEPHROL, V31, P817, DOI 10.1681/ASN.2019080811
   Cheng K, 2019, INFLAMMATION, V42, P937, DOI 10.1007/s10753-018-0948-7
   Cho IJ, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-88872-7
   Chou HW, 2018, NEPHROL DIAL TRANSPL, V33, P1620, DOI 10.1093/ndt/gfx313
   Cohen Paul, 2003, Current Drug Targets - Immune Endocrine and Metabolic Disorders, V3, P271, DOI 10.2174/1568008033340117
   Czech MP, 2020, MOL METAB, V34, P27, DOI 10.1016/j.molmet.2019.12.014
   Dalbeth N, 2009, RHEUMATOLOGY, V48, P222, DOI 10.1093/rheumatology/ken460
   Deis T, 2022, OPEN HEART, V9, DOI 10.1136/openhrt-2022-002092
   Deng XL, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1143458
   Dobrzyn A, 2004, TRENDS CARDIOVAS MED, V14, P77, DOI 10.1016/j.tcm.2003.12.005
   Doehner W, 2022, EUR HEART J, V43, P3435, DOI 10.1093/eurheartj/ehac320
   Doshi M, 2011, NUCLEOS NUCLEOT NUCL, V30, P1290, DOI 10.1080/15257770.2011.603711
   Enomoto A, 2002, NATURE, V417, P447, DOI 10.1038/nature742
   FACCHINI F, 1991, JAMA-J AM MED ASSOC, V266, P3008, DOI 10.1001/jama.266.21.3008
   Feig DI, 2013, J PEDIATR-US, V162, P896, DOI 10.1016/j.jpeds.2012.12.078
   Francque S, 2015, J HEPATOL, V63, P164, DOI 10.1016/j.jhep.2015.02.019
   Friedman SL, 2018, NAT MED, V24, P908, DOI 10.1038/s41591-018-0104-9
   GALVAN AQ, 1995, AM J PHYSIOL-ENDOC M, V268, pE1, DOI 10.1152/ajpendo.1995.268.1.E1
   Goicoechea M, 2015, AM J KIDNEY DIS, V65, P543, DOI 10.1053/j.ajkd.2014.11.016
   Goicoechea M, 2010, CLIN J AM SOC NEPHRO, V5, P1388, DOI 10.2215/CJN.01580210
   Guan XD, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.998441
   Han YD, 2023, J TRANSL MED, V21, DOI 10.1186/s12967-023-04307-z
   Hashimoto H, 2023, CLIN RHEUMATOL, V42, P3075, DOI 10.1007/s10067-023-06710-9
   Hinds TD, 2017, AM J PHYSIOL-ENDOC M, V312, pE291, DOI 10.1152/ajpendo.00396.2016
   Hinds TD, 2016, J BIOL CHEM, V291, P25179, DOI 10.1074/jbc.M116.731703
   Hinds TD, 2016, MED HYPOTHESES, V95, P54, DOI 10.1016/j.mehy.2016.08.013
   Hjortnaes J, 2007, J RHEUMATOL, V34, P1882
   Holle J, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0240446
   Horino T, 2018, CLIN EXP NEPHROL, V22, P337, DOI 10.1007/s10157-017-1452-3
   Hsu YSO, 2020, CLIN PHARMACOL THER, V107, P1159, DOI 10.1002/cpt.1697
   Hsueh CH, 2016, MOL PHARMACEUT, V13, P3130, DOI 10.1021/acs.molpharmaceut.6b00332
   Iseki K, 2004, AM J KIDNEY DIS, V44, P642, DOI [10.1016/S0272-6386(04)00934-5, 10.1053/j.ajkd.2004.06.006]
   Johnson RJ, 2003, HYPERTENSION, V41, P1183, DOI 10.1161/01.HYP.0000069700.62727.C5
   Kamijo-Ikemori A, 2013, CLIN CHIM ACTA, V424, P104, DOI 10.1016/j.cca.2013.05.020
   Kang DH, 2005, J AM SOC NEPHROL, V16, P3553, DOI 10.1681/ASN.2005050572
   Kang EH, 2021, EUR HEART J, V42, P4578, DOI 10.1093/eurheartj/ehab619
   Kario K, 2021, J CLIN HYPERTENS, V23, P334, DOI 10.1111/jch.14153
   Ke JH, 2023, CURR MED RES OPIN, V39, P947, DOI 10.1080/03007995.2023.2223916
   Keembiyehetty C, 2006, MOL ENDOCRINOL, V20, P686, DOI 10.1210/me.2005-0010
   Kielstein JT, 2004, CIRCULATION, V109, P172, DOI 10.1161/01.CIR.0000105764.22626.B1
   Kim SH, 2020, KOREAN J INTERN MED, V35, P998, DOI 10.3904/kjim.2018.423
   Kim SC, 2018, J AM COLL CARDIOL, V71, P994, DOI 10.1016/j.jacc.2017.12.052
   Kim S, 2017, KIDNEY RES CLIN PRAC, V36, P274, DOI 10.23876/j.krcp.2017.36.3.274
   Kim YE, 2024, JOINT BONE SPINE, V91, DOI 10.1016/j.jbspin.2023.105668
   Kurihara O, 2024, CLIN EXP NEPHROL, V28, P208, DOI 10.1007/s10157-023-02419-w
   Kwon MM, 2015, CELL REP, V13, P1521, DOI 10.1016/j.celrep.2015.10.021
   Li S, 2007, PLOS GENET, V3, P2156, DOI 10.1371/journal.pgen.0030194
   Lin CJ, 2011, J CLIN LAB ANAL, V25, P191, DOI 10.1002/jcla.20456
   Liu X., 2023, Nutr. Metab. Cardiovasc. Dis
   MADDUX BA, 1995, NATURE, V373, P448, DOI 10.1038/373448a0
   Mallat SG, 2016, CURR HYPERTENS REP, V18, DOI 10.1007/s11906-016-0684-z
   Mandal AK, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.713710
   Maruhashi T, 2022, FRONT CARDIOVASC MED, V9, DOI 10.3389/fcvm.2022.882821
   Matsuo H, 2009, SCI TRANSL MED, V1, DOI 10.1126/scitranslmed.3000237
   Mazzali M, 2001, HYPERTENSION, V38, P1101, DOI 10.1161/hy1101.092839
   Merriman TR, 2011, JOINT BONE SPINE, V78, P35, DOI 10.1016/j.jbspin.2010.02.027
   Miao ZM, 2009, INFLAMM RES, V58, P659, DOI 10.1007/s00011-009-0031-9
   Miyata Hiroshi, Identification of Febuxostat as a New Strong ABCG2 Inhibitor: Potential Applications and Risks in Clinical Situations
   Miyoshi T, 2021, J CARDIOL, V78, P493, DOI 10.1016/j.jjcc.2021.07.011
   Miyoshi T, 2021, J AM HEART ASSOC, V10, DOI 10.1161/JAHA.120.020103
   Muniyappa R, 2013, REV ENDOCR METAB DIS, V14, P5, DOI 10.1007/s11154-012-9229-1
   Muscelli E, 1996, AM J HYPERTENS, V9, P746, DOI 10.1016/0895-7061(96)00098-2
   Nadwa EH, 2021, PHARMACOLOGY, V106, P564, DOI 10.1159/000516495
   Nagura M, 2016, NUCLEOS NUCLEOT NUCL, V35, P550, DOI 10.1080/15257770.2016.1163379
   Nakamura T, 2021, NUTR DIABETES, V11, DOI 10.1038/s41387-021-00155-2
   Nakata T, 2020, INT HEART J, V61, P984, DOI 10.1536/ihj.20-114
   Nata N, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-40767-5
   Niwa T, 2010, NAGOYA J MED SCI, V72, P1
   Notsu T, 2023, HYPERTENS RES, V46, P2368, DOI 10.1038/s41440-023-01391-y
   Öztekin GMY, 2022, HELL J CARDIOL, V65, P35, DOI 10.1016/j.hjc.2022.03.009
   Packer M, 2020, J CARD FAIL, V26, P977, DOI 10.1016/j.cardfail.2020.08.015
   Pan JA, 2020, HEART VESSELS, V35, P1446, DOI 10.1007/s00380-020-01619-8
   Price KL, 2006, J AM SOC NEPHROL, V17, P1791, DOI 10.1681/ASN.2006030264
   Rahman SM, 2005, AM J PHYSIOL-ENDOC M, V288, pE381, DOI 10.1152/ajpendo.00314.2004
   Ran ZJ, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.724822
   Reinders MK, 2007, CLIN RHEUMATOL, V26, P1459, DOI 10.1007/s10067-006-0528-3
   Roubille C, 2022, INTERN EMERG MED, V17, P1661, DOI 10.1007/s11739-022-02982-2
   Saldanha JF, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/963217
   Sanikidze Q, 2021, Georgian Med News, P85
   Sattui SE, 2016, THER ADV MUSCULOSKEL, V8, P145, DOI 10.1177/1759720X16646703
   Sautin YY, 2007, AM J PHYSIOL-CELL PH, V293, pC584, DOI 10.1152/ajpcell.00600.2006
   Shen H, 2019, J PHARMACOL EXP THER, V368, P136, DOI 10.1124/jpet.118.252643
   Shen H, 2018, DRUG METAB DISPOS, V46, P178, DOI 10.1124/dmd.117.077586
   Shibagaki Y, 2014, HYPERTENS RES, V37, P919, DOI 10.1038/hr.2014.107
   Siu YP, 2006, AM J KIDNEY DIS, V47, P51, DOI 10.1053/j.ajkd.2005.10.006
   Skalova Sylva, 2005, Acta Medica (Hradec Kralove), V48, P75
   Soletsky B, 2012, HYPERTENSION, V60, P1148, DOI 10.1161/HYPERTENSIONAHA.112.196980
   Soriguer F, 2007, MOL NUTR FOOD RES, V51, P1260, DOI 10.1002/mnfr.200700021
   Spiga R, 2017, ARTERIOSCL THROM VAS, V37, P1241, DOI 10.1161/ATVBAHA.117.309128
   Stec DE, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0153427
   Su MQ, 2020, CLIN SCI, V134, P1537, DOI 10.1042/CS20200580
   Sung SH, 2020, INT J CARDIOL, V300, P178, DOI 10.1016/j.ijcard.2019.11.001
   Swanson KV, 2019, NAT REV IMMUNOL, V19, P477, DOI 10.1038/s41577-019-0165-0
   Takada T, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-29208-w
   Takae K, 2016, CIRC J, V80, P1857, DOI 10.1253/circj.CJ-16-0030
   Takahashi S, 1997, METABOLISM, V46, P1162, DOI 10.1016/S0026-0495(97)90210-9
   Tan SPF, 2022, CLIN PHARMACOL THER, V112, P643, DOI 10.1002/cpt.2642
   Tanaka A, 2023, EUR J MED RES, V28, DOI 10.1186/s40001-023-01208-1
   Tanaka K, 2015, CLIN EXP NEPHROL, V19, P1044, DOI 10.1007/s10157-015-1095-1
   Tanaka Y, 2023, ISCIENCE, V26, DOI 10.1016/j.isci.2023.107730
   Tanaka Y, 2022, MOL METAB, V55, DOI 10.1016/j.molmet.2021.101411
   Taniguchi T, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-86662-9
   Taniguchi T, 2019, J PHARMACOL EXP THER, V371, P162, DOI 10.1124/jpet.119.259341
   Tassone EJ, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00098
   terMaaten JC, 1997, CLIN SCI, V92, P51
   Thiel G, 2017, PHARMACOL RES, V117, P166, DOI 10.1016/j.phrs.2016.12.029
   Toyoki D, 2017, AM J PHYSIOL-RENAL, V313, pF826, DOI 10.1152/ajprenal.00012.2017
   Tsukamoto S, 2022, CLIN RHEUMATOL, V41, P911, DOI 10.1007/s10067-021-05956-5
   Tsuruta Y, 2014, CLIN RHEUMATOL, V33, P1643, DOI 10.1007/s10067-014-2745-5
   Uchida S, 2018, CONTRIB NEPHROL, V192, P56, DOI 10.1159/000484279
   Uedono H, 2015, KIDNEY BLOOD PRESS R, V40, P315, DOI 10.1159/000368507
   VALLANCE P, 1992, LANCET, V339, P572
   Vijay PS, 2023, CUREUS J MED SCIENCE, V15, DOI 10.7759/cureus.45246
   Vitart V, 2008, NAT GENET, V40, P437, DOI 10.1038/ng.106
   Wang C, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1131566
   Wang K, 2020, CLIN J AM SOC NEPHRO, V15, P80, DOI 10.2215/CJN.05610519
   Wang XQ, 2022, FRONT CARDIOVASC MED, V9, DOI 10.3389/fcvm.2022.853870
   Wang YP, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21062061
   Weber M, 2023, BIOLOGY-BASEL, V12, DOI 10.3390/biology12010004
   Willemin ME, 2021, CLIN PHARMACOKINET, V60, P1187, DOI 10.1007/s40262-021-01004-2
   Woodward OM, 2009, P NATL ACAD SCI USA, V106, P10338, DOI 10.1073/pnas.0901249106
   Wu HY, 2023, BMC CARDIOVASC DISOR, V23, DOI 10.1186/s12872-023-03040-1
   Wu W, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-04949-2
   Xin W, 2016, CARDIOVASC THER, V34, P441, DOI 10.1111/1755-5922.12215
   Xu LQ, 2017, ONCOTARGET, V8, P100852, DOI 10.18632/oncotarget.20135
   Yanai H, 2023, METABOLITES, V13, DOI 10.3390/metabo13060736
   Yanai H, 2023, BIOMEDICINES, V11, DOI 10.3390/biomedicines11020567
   Yanai H, 2022, CARDIOL RES, V13, P309, DOI 10.14740/cr1424
   Yanai H, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22179221
   Yanai K, 2023, DRUG DES DEV THER, V17, P3233, DOI 10.2147/DDDT.S416025
   Yang Y, 2015, J ETHNOPHARMACOL, V169, P49, DOI 10.1016/j.jep.2015.04.011
   Yilmaz MI, 2006, AM J KIDNEY DIS, V47, P42, DOI 10.1053/j.ajkd.2005.09.029
   Yuan HP, 2015, J CLIN ENDOCR METAB, V100, P4198, DOI 10.1210/jc.2015-2527
   Zhang HL, 2020, J CELL MOL MED, V24, P8849, DOI 10.1111/jcmm.15523
   Zhang XJ, 2020, AM J TRANSL RES, V12, P1894
   Zhang XM, 2021, MOL MED REP, V24, DOI 10.3892/mmr.2021.12203
NR 146
TC 8
Z9 8
U1 13
U2 22
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD MAR
PY 2024
VL 13
IS 5
AR 450
DI 10.3390/cells13050450
PG 24
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA KV2Y3
UT WOS:001182685100001
PM 38474414
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Fields, CT
   Chassaing, B
   de Vries, GJ
AF Fields, Christopher T.
   Chassaing, Benoit
   de Vries, Geert J.
TI Gut barrier dysfunction and type 2 immunity: Implications for compulsive
   behavior
SO MEDICAL HYPOTHESES
LA English
DT Article
DE Type 2 inflammation; Compulsive behavior; Gut barrier dysfunction;
   Gut-brain axis; Autism spectrum disorders; Addiction
ID TOURETTE SYNDROME; SEX-DIFFERENCES; HISTIDINE-DECARBOXYLASE; INTESTINAL
   PERMEABILITY; REPETITIVE BEHAVIOR; SPECTRUM DISORDERS; METABOLIC
   SYNDROME; ALLERGIC DISEASE; VAGAL PATHWAYS; ANIMAL-MODELS
AB To date, much of the focus of gut-brain axis research has been on gut microbiota regulation of anxiety and stressrelated behaviors. Much less attention has been directed to potential connections between gut microbiota and compulsive behavior. Here, we discuss a potential link between gut barrier dysfunction and compulsive behavior that is mediated through "type 2" rather than "type 1" inflammation. We examine connections between compulsive behavior and type 2 inflammation in Tourette syndrome, obsessive-compulsive disorder, autism, addiction, and post-traumatic stress disorder. Next, we discuss potential connections between gut barrier dysfunction, type 2 inflammation, and compulsive behavior. We posit a potential mechanism whereby gut barrier dysfunction-associated type 2 inflammation may drive compulsive behavior through histamine regulation of dopamine neurotransmission. Finally, we discuss the possibility of exploiting the greater accessibility of the gut relative to the brain in identifying targets to treat compulsive behavior disorders.
C1 [Fields, Christopher T.] Yale Univ, Dept Psychiat, New Haven, CT 06519 USA.
   [Chassaing, Benoit] Univ Paris, Team Mucosal Microbiota Chron Inflammatory Dis, Inserm U1016, CNRS UMR 8104, F-75014 Paris, France.
   [de Vries, Geert J.] Georgia State Univ, Dept Biol, Atlanta, GA 30303 USA.
   [de Vries, Geert J.] Georgia State Univ, Neurosci Inst, Atlanta, GA 30303 USA.
C3 Yale University; Universite Paris Cite; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Centre National de la Recherche
   Scientifique (CNRS); CNRS - National Institute for Biology (INSB);
   University System of Georgia; Georgia State University; University
   System of Georgia; Georgia State University
RP Fields, CT (corresponding author), Yale Univ, Dept Psychiat, New Haven, CT 06519 USA.
EM christopher.fields@yale.edu; benoit.chassaing@inserm.fr; devries@gsu.edu
RI Chassaing, Benoit/R-3819-2017
OI Fields, Christopher/0000-0002-2054-7316; de Vries, Geert
   J./0000-0002-1263-3775
FU NIH [MH112369, MH108345]
FX This work was supported by NIH Grant No. MH112369 (to CTF) and MH108345
   (to GJD) . The authors report no biomedical financial interest or
   potential conflicts of interest.
CR Akira S, 2004, NAT REV IMMUNOL, V4, P499, DOI 10.1038/nri1391
   Albert U, 2013, GEN HOSP PSYCHIAT, V35, P154, DOI 10.1016/j.genhosppsych.2012.10.004
   Alevizos M, 2014, ANN ALLERG ASTHMA IM, V112, P309, DOI 10.1016/j.anai.2013.09.017
   Alvarenga DM, 2015, ALCOHOL CLIN EXP RES, V39, P1453, DOI 10.1111/acer.12770
   American Psychiatric Association, 2013, Diagnostic and statistical manual of mental disorders: DSM-5 TM, V44
   Amodeo DA, 2012, BEHAV BRAIN RES, V227, P64, DOI 10.1016/j.bbr.2011.10.032
   Andrews G, 2001, BRIT J PSYCHIAT, V178, P145, DOI 10.1192/bjp.178.2.145
   [Anonymous], 2011, N. Sci., DOI DOI 10.1016/S0262-4079(11)60124-3
   Anthony RM, 2011, NATURE, V475, P110, DOI 10.1038/nature10134
   Assimakopoulos SF, 2018, GASTROENTEROL RES, V11, P261, DOI 10.14740/gr1053w
   Balázsfi D, 2015, PSYCHONEUROENDOCRINO, V51, P11, DOI 10.1016/j.psyneuen.2014.09.011
   Baldan LC, 2014, NEURON, V81, P77, DOI 10.1016/j.neuron.2013.10.052
   Barker JM, 2015, ALCOHOL, V49, P817, DOI 10.1016/j.alcohol.2015.03.003
   BARON JL, 1993, J EXP MED, V177, P57, DOI 10.1084/jem.177.1.57
   Bercik P, 2011, NEUROGASTROENT MOTIL, V23, P1132, DOI 10.1111/j.1365-2982.2011.01796.x
   Bernal A, 2016, NEUROSCI BIOBEHAV R, V66, P1, DOI 10.1016/j.neubiorev.2016.02.023
   Beurel E, 2013, J IMMUNOL, V190, P5000, DOI 10.4049/jimmunol.1203057
   Bhikram T, 2017, J PSYCHIATR NEUROSCI, V42, P300, DOI 10.1503/jpn.160079
   Bluthe RM, 1996, NEUROREPORT, V7, P1485, DOI 10.1097/00001756-199606170-00008
   Bower JH, 2006, NEUROLOGY, V67, P494, DOI 10.1212/01.wnl.0000227906.99570.cc
   Bruce-Keller AJ, 2015, BIOL PSYCHIAT, V77, P607, DOI 10.1016/j.biopsych.2014.07.012
   Calipari ES, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-017-01881-x
   Campos LM, 2015, PSYCHIAT RES, V229, P401, DOI 10.1016/j.psychres.2015.05.111
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Caria A, 2020, BRAIN SCI, V10, DOI 10.3390/brainsci10070435
   Casimir GJA, 2010, J INFLAMM-LOND, V7, DOI 10.1186/1476-9255-7-28
   Chang YT, 2011, J DEV BEHAV PEDIATR, V32, P98, DOI 10.1097/DBP.0b013e318208f561
   Chassaing Benoit, 2014, Biomed J, V37, P246, DOI 10.4103/2319-4170.130922
   CHEN JF, 1994, NEUROCHEM INT, V25, P355, DOI 10.1016/0197-0186(94)90143-0
   Chen MH, 2014, J PSYCHOSOM RES, V77, P316, DOI 10.1016/j.jpsychores.2014.06.006
   Chepkova A, 2012, CELL MOL NEUROBIOL, V32, P17, DOI 10.1007/s10571-011-9730-1
   Cho KA, 2017, BIOCHEM BIOPH RES CO, V487, P856, DOI 10.1016/j.bbrc.2017.04.141
   Chopyk DM, 2017, PHYSIOL REP, V5, DOI 10.14814/phy2.13541
   Contreras-Rodríguez O, 2017, BIOL PSYCHIAT, V81, P789, DOI 10.1016/j.biopsych.2015.11.020
   Contreras-Rodríguez O, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-09874-y
   Cortés A, 2017, TRENDS PARASITOL, V33, P678, DOI 10.1016/j.pt.2017.05.004
   Costa-Pinto FA, 2005, BRAIN BEHAV IMMUN, V19, P52, DOI 10.1016/j.bbi.2004.02.005
   Crawford LK, 2013, ACS CHEM NEUROSCI, V4, P200, DOI 10.1021/cn300238j
   Cuthbert BN, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-126
   Dantzer R, 2009, IMMUNOL ALLERGY CLIN, V29, P247, DOI 10.1016/j.iac.2009.02.002
   de Haan JJ, 2009, CRIT CARE, V13, DOI 10.1186/cc7910
   de Magistris L, 2010, J PEDIATR GASTR NUTR, V51, P418, DOI 10.1097/MPG.0b013e3181dcc4a5
   de Mathis MA, 2011, REV BRAS PSIQUIATR, V33, P390, DOI 10.1590/S1516-44462011000400014
   de Theije CGM, 2014, BEHAV BRAIN RES, V261, P265, DOI 10.1016/j.bbr.2013.12.008
   Demeter K, 2016, BEHAV BRAIN RES, V300, P123, DOI 10.1016/j.bbr.2015.12.007
   Derenne JL, 2009, PSYCHOSOMATICS, V50, P425, DOI 10.1176/appi.psy.50.4.425
   Desbonnet L, 2014, MOL PSYCHIATR, V19, P146, DOI 10.1038/mp.2013.65
   Dillon S, 2004, J IMMUNOL, V172, P4733, DOI 10.4049/jimmunol.172.8.4733
   Dixit VD, 2003, BIOL REPROD, V68, P2215, DOI 10.1095/biolreprod.102.012211
   Dykshoorn KL, 2014, HEALTH PSYCHOL BEHAV, V2, P517, DOI 10.1080/21642850.2014.905207
   Ercan-Sencicek AG, 2010, NEW ENGL J MED, V362, P1901, DOI 10.1056/NEJMoa0907006
   Feldberg RS, 1998, INFLAMM RES, V47, P245, DOI 10.1007/s000110050325
   Ferrier L, 2010, AM J PHYSIOL-GASTR L, V299, pG1298, DOI 10.1152/ajpgi.00022.2010
   Fields CT, 2018, GUT MICROBES, V9, P13, DOI 10.1080/19490976.2017.1356557
   Fields CT, 2018, BIOL SEX DIFFER, V9, DOI 10.1186/s13293-018-0166-x
   Figee M, 2016, EUR NEUROPSYCHOPHARM, V26, P856, DOI 10.1016/j.euroneuro.2015.12.003
   Fodor A, 2016, PHYSIOL BEHAV, V158, P100, DOI 10.1016/j.physbeh.2016.02.041
   Fontenelle LF, 2012, J ANXIETY DISORD, V26, P377, DOI 10.1016/j.janxdis.2011.12.001
   Forsythe P, 2014, ADV EXP MED BIOL, V817, P115, DOI 10.1007/978-1-4939-0897-4_5
   Fostick L, 2012, WORLD J BIOL PSYCHIA, V13, P312, DOI 10.3109/15622975.2011.607848
   Freeman RD, 2007, EUR CHILD ADOLES PSY, V16, P15, DOI 10.1007/s00787-007-1003-7
   Friedlander L, 2006, CLIN PSYCHOL REV, V26, P32, DOI 10.1016/j.cpr.2005.06.010
   Fulceri F, 2016, RES DEV DISABIL, V48, P43, DOI 10.1016/j.ridd.2015.10.015
   Furlano RI, 2001, J PEDIATR-US, V138, P366, DOI 10.1067/mpd.2001.111323
   Gentile A, 2016, J NEUROINFLAMM, V13, DOI 10.1186/s12974-016-0682-8
   Gentile A, 2015, NEUROBIOL DIS, V74, P347, DOI 10.1016/j.nbd.2014.11.022
   Gillan CM, 2016, EUR NEUROPSYCHOPHARM, V26, P828, DOI 10.1016/j.euroneuro.2015.12.033
   Gillan CM, 2014, BIOL PSYCHIAT, V75, P631, DOI 10.1016/j.biopsych.2013.02.002
   Goehler LE, 1997, BRAIN RES BULL, V43, P357, DOI 10.1016/S0361-9230(97)00020-8
   Goldenberg RL, 2006, AM J OBSTET GYNECOL, V195, P1533, DOI 10.1016/j.ajog.2006.05.023
   González-Reimers E, 2014, WORLD J GASTROENTERO, V20, P14660, DOI 10.3748/wjg.v20.i40.14660
   Harrop C, 2015, J AUTISM DEV DISORD, V45, P766, DOI 10.1007/s10803-014-2234-3
   Hart BL, 2018, PHILOS T R SOC B, V373, DOI 10.1098/rstb.2017.0205
   Hattay P, 2017, NEUROGASTROENT MOTIL, V29, DOI 10.1111/nmo.13043
   Heijtza RD, 2011, P NATL ACAD SCI USA, V108, P3047, DOI 10.1073/pnas.1010529108
   Heo Y, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020912
   Hodes GE, 2014, P NATL ACAD SCI USA, V111, P16136, DOI 10.1073/pnas.1415191111
   Honda K, 2009, MUCOSAL IMMUNOL, V2, P187, DOI 10.1038/mi.2009.8
   Honda K, 2016, NATURE, V535, P75, DOI 10.1038/nature18848
   Howard CD, 2017, NEURON, V93, P1436, DOI 10.1016/j.neuron.2017.02.029
   Hsiao EY, 2013, CELL, V155, P1451, DOI 10.1016/j.cell.2013.11.024
   Hu YZ, 2015, JAMA PSYCHIAT, V72, P584, DOI 10.1001/jamapsychiatry.2015.1
   Huppert JD, 2005, J ANXIETY DISORD, V19, P127, DOI 10.1016/j.janxdis.2004.01.001
   Huuskonen J, 2004, BRIT J PHARMACOL, V141, P874, DOI 10.1038/sj.bjp.0705682
   Imai H, 2012, NMR BIOMED, V25, P210, DOI 10.1002/nbm.1733
   Johnson AMF, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0122195
   Jury NJ, 2017, ALCOHOL, V58, P53, DOI 10.1016/j.alcohol.2016.07.007
   Kang DW, 2017, MICROBIOME, V5, DOI 10.1186/s40168-016-0225-7
   Karagiannidis I, 2013, J MED GENET, V50, P760, DOI 10.1136/jmedgenet-2013-101637
   Keeler JF, 2014, NEUROSCIENCE, V282, P156, DOI 10.1016/j.neuroscience.2014.07.021
   Kelly Caleb, 2009, J Allergy (Cairo), V2009, P159845, DOI 10.1155/2009/159845
   Kempski J, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01373
   Khegai II, 2003, B EXP BIOL MED+, V136, P448, DOI 10.1023/B:BEBM.0000017089.28428.1c
   Kidd Parris, 2003, Altern Med Rev, V8, P223
   Kim JY, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0116540
   Klarer M, 2018, J NEUROSCI, V38, P1634, DOI 10.1523/JNEUROSCI.0813-17.2017
   Klein SL, 2016, NAT REV IMMUNOL, V16, P626, DOI 10.1038/nri.2016.90
   König J, 2016, CLIN TRANSL GASTROEN, V7, DOI 10.1038/ctg.2016.54
   Lauw FN, 2000, INFECT IMMUN, V68, P1014, DOI 10.1128/IAI.68.3.1014-1018.2000
   Legroux L, 2015, J NEUROIMMUNE PHARM, V10, P528, DOI 10.1007/s11481-015-9614-0
   Lenz KM, 2013, J NEUROSCI, V33, P2761, DOI 10.1523/JNEUROSCI.1268-12.2013
   Li X, 2013, ALIMENT PHARM THER, V37, P799, DOI 10.1111/apt.12269
   Liao W, 2017, MOL NEUROBIOL, V54, P2781, DOI 10.1007/s12035-016-9863-9
   LIBLAU RS, 1995, IMMUNOL TODAY, V16, P34, DOI 10.1016/0167-5699(95)80068-9
   Lichter DG, 2015, EUR PSYCHIAT, V30, DOI 10.1016/j.eurpsy.2014.07.003
   Lin JC, 2016, INFLAMM BOWEL DIS, V22, P1049, DOI 10.1097/MIB.0000000000000735
   Liu Chieh-An, 2003, Chang Gung Med J, V26, P561
   Liu SX, 2017, WORLD J GASTROENTERO, V23, P8570, DOI 10.3748/wjg.v23.i48.8570
   Lynch SV, 2016, ANN AM THORAC SOC, V13, pS51, DOI 10.1513/AnnalsATS.201507-451MG
   Ma ZH, 2022, AUTISM, V26, P1108, DOI 10.1177/13623613211041904
   Martin NT, 2016, NAT IMMUNOL, V17, P122, DOI 10.1038/ni.3370
   Martini E, 2017, CELL MOL GASTROENTER, V4, P33, DOI 10.1016/j.jcmgh.2017.03.007
   Masand PS, 2006, CNS SPECTRUMS, V11, P21, DOI 10.1017/S1092852900024123
   Mayer EA, 2014, J NEUROSCI, V34, P15490, DOI 10.1523/JNEUROSCI.3299-14.2014
   Mazmanian SK, 2005, CELL, V122, P107, DOI 10.1016/j.cell.2005.05.007
   McCoy KD, 2018, CURR OPIN IMMUNOL, V54, P20, DOI 10.1016/j.coi.2018.05.009
   McNaughton CH, 2008, BEHAV NEUROSCI, V122, P293, DOI 10.1037/0735-7044.122.2.293
   Mehta MV, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026077
   Meng LH, 2016, SCI REP-UK, V6, DOI 10.1038/srep33748
   MIELE GM, 1990, BRIT J ADDICT, V85, P1421
   Mills CD, 2000, J IMMUNOL, V164, P6166, DOI 10.4049/jimmunol.164.12.6166
   Moy SS, 2008, BEHAV BRAIN RES, V191, P118, DOI 10.1016/j.bbr.2008.03.015
   Mukherjee S, 2009, J BIOL CHEM, V284, P29391, DOI 10.1074/jbc.M109.005272
   Murray SL, 2021, APPETITE, V167, DOI 10.1016/j.appet.2021.105599
   Neufeld KM, 2011, NEUROGASTROENT MOTIL, V23, DOI 10.1111/j.1365-2982.2010.01620.x
   Niemiec MA, 2016, OBESITY, V24, P1803, DOI 10.1002/oby.21529
   Nieto-Alamilla G, 2016, MOL PHARMACOL, V90, P649, DOI 10.1124/mol.116.104752
   Nishino R, 2013, NEUROGASTROENT MOTIL, V25, DOI 10.1111/nmo.12110
   Nowakowska-Domagala K, 2016, ALCOHOL CLIN EXP RES, V40, P401, DOI 10.1111/acer.12954
   Olatunji BO, 2017, J ANXIETY DISORD, V51, P86, DOI 10.1016/j.janxdis.2017.06.005
   Palm NW, 2012, NATURE, V484, P465, DOI 10.1038/nature11047
   Palumbo Donna, 2007, Neuropsychiatr Dis Treat, V3, P687
   Park SJ, 2015, SCI REP-UK, V5, DOI 10.1038/srep08502
   Pastorelli L, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/608187
   Paul MJ, 2016, ENEURO, V3, DOI 10.1523/ENEURO.0150-15.2016
   Porcelli P, 2007, PSYCHOSOMATICS, V48, P448, DOI 10.1176/appi.psy.48.5.448
   Powley TL, 2011, J COMP NEUROL, V519, P644, DOI 10.1002/cne.22541
   Provensi G, 2020, BRIT J PHARMACOL, V177, P557, DOI 10.1111/bph.14476
   Quaglieri A, 2020, BRAIN SCI, V10, DOI 10.3390/brainsci10060353
   Ramirez K, 2017, CURR TOP BEHAV NEURO, V31, P155, DOI 10.1007/7854_2016_25
   Rapanelli M, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/tp.2016.290
   Rapanelli M, 2017, P NATL ACAD SCI USA, V114, P6599, DOI 10.1073/pnas.1704547114
   Rapanelli M, 2016, NEUROPHARMACOLOGY, V106, P85, DOI 10.1016/j.neuropharm.2015.08.019
   Rees JC, 2014, MED HYPOTHESES, V82, P163, DOI 10.1016/j.mehy.2013.11.026
   ROBINSON TE, 1993, BRAIN RES REV, V18, P247, DOI 10.1016/0165-0173(93)90013-P
   Roth CL, 2015, J CLIN MED, V4, P1774, DOI 10.3390/jcm4091774
   Roved J, 2017, HORM BEHAV, V88, P95, DOI 10.1016/j.yhbeh.2016.11.017
   Saini V, 2011, CLIN CHIM ACTA, V412, P702, DOI 10.1016/j.cca.2011.01.002
   Sakai Y, 2011, EUR PSYCHIAT, V26, P463, DOI 10.1016/j.eurpsy.2010.09.005
   Saluja R, 2015, CLIN TRANSL ALLERGY, V5, DOI 10.1186/s13601-015-0076-5
   Sampson TR, 2016, CELL, V167, P1469, DOI 10.1016/j.cell.2016.11.018
   Savignac HM, 2016, BRAIN BEHAV IMMUN, V52, P120, DOI 10.1016/j.bbi.2015.10.007
   SCHLICKER E, 1993, J NEURAL TRANSM-GEN, V93, P1, DOI 10.1007/BF01244933
   Schneider T, 2008, PSYCHONEUROENDOCRINO, V33, P728, DOI 10.1016/j.psyneuen.2008.02.011
   Schwabe L, 2009, J NEUROSCI, V29, P7191, DOI 10.1523/JNEUROSCI.0979-09.2009
   Schwartzer JJ, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.40
   Schwartzer JJ, 2017, BRAIN BEHAV IMMUN, V63, P99, DOI 10.1016/j.bbi.2016.09.007
   Sesia T, 2013, INT J NEUROPSYCHOPH, V16, P1295, DOI 10.1017/S146114571200154X
   Spellberg B, 2001, CLIN INFECT DIS, V32, P76, DOI 10.1086/317537
   Sun Y, 2016, ACTA PHARMACOL SIN, V37, P1325, DOI 10.1038/aps.2016.66
   Sung N, 2016, AM J REPROD IMMUNOL, V76, P50, DOI 10.1111/aji.12522
   Swanson GR, 2016, AM J PHYSIOL-GASTR L, V311, pG192, DOI 10.1152/ajpgi.00087.2016
   SWEDO SE, 1989, ARCH GEN PSYCHIAT, V46, P335
   Szabo G, 2015, GASTROENTEROLOGY, V148, P30, DOI 10.1053/j.gastro.2014.10.042
   Teixeira TFS, 2012, CLIN NUTR, V31, P735, DOI 10.1016/j.clnu.2012.02.009
   The National Institute of Mental Health, 2016, RES DOMAIN CRITERIA
   Theoharides TC, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.77
   Thomas A, 2009, PSYCHOPHARMACOLOGY, V204, P361, DOI 10.1007/s00213-009-1466-y
   TUOMISTO L, 1986, AGENTS ACTIONS, V18, P219, DOI 10.1007/BF01988025
   Turna J, 2017, PSYCHIAT ANN, V47, P542, DOI 10.3928/00485713-20171013-01
   Turna J, 2016, DEPRESS ANXIETY, V33, P171, DOI 10.1002/da.22454
   Umathe S, 2008, EUR J PHARMACOL, V587, P175, DOI 10.1016/j.ejphar.2008.03.035
   Unterwald Ellen M., 2009, P19, DOI 10.1007/978-1-59745-197-0_2
   van Steensel FJA, 2011, CLIN CHILD FAM PSYCH, V14, P302, DOI 10.1007/s10567-011-0097-0
   VANDERVEEN RC, 1993, J NEUROIMMUNOL, V48, P213, DOI 10.1016/0165-5728(93)90194-4
   Vanuytsel T, 2014, GUT, V63, P1293, DOI 10.1136/gutjnl-2013-305690
   Wen F, 2021, BMC PSYCHIATRY, V21, DOI 10.1186/s12888-021-03187-1
   WILKIE DM, 1979, J EXP ANAL BEHAV, V31, P299, DOI 10.1901/jeab.1979.31-299
   Witthauer C, 2014, SOC PSYCH PSYCH EPID, V49, P2013, DOI 10.1007/s00127-014-0895-z
   Wright C, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/tp.2017.87
   Xiao B, 2017, MOL THER, V25, P1628, DOI 10.1016/j.ymthe.2016.11.020
   Yaghmaie P, 2013, J ALLERGY CLIN IMMUN, V131, P428, DOI 10.1016/j.jaci.2012.10.041
   Yamamoto K, 2016, TRANSFUS MED HEMOTH, V43, P433, DOI 10.1159/000446814
   Yu Linda Chia-Hui, 2012, J Allergy (Cairo), V2012, P596081, DOI 10.1155/2012/596081
   Yu W, 2016, NAT REV IMMUNOL, V16, P751, DOI 10.1038/nri.2016.111
   Yuce M, 2014, EUR REV MED PHARMACO, V18, P303
   Zerbo O, 2015, BRAIN BEHAV IMMUN, V46, P232, DOI 10.1016/j.bbi.2015.02.001
   Zhan Y, 2014, NAT NEUROSCI, V17, P400, DOI 10.1038/nn.3641
   Zhao HS, 2017, CASE REP MED, V2017, P3
   Zimmermann AS, 2011, INFLAMM RES, V60, P1153, DOI 10.1007/s00011-011-0379-5
NR 190
TC 2
Z9 2
U1 0
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD APR
PY 2022
VL 161
AR 110799
DI 10.1016/j.mehy.2022.110799
EA FEB 2022
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA ZO2UY
UT WOS:000765586700008
PM 36060122
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lee, IS
   Ko, SJ
   Lee, YN
   Lee, G
   Rahman, H
   Kim, B
AF Lee, In-Seon
   Ko, Seok-Jae
   Lee, Yu Na
   Lee, Gahyun
   Rahman, Hasanur
   Kim, Bonglee
TI The Effect of Laminaria japonica on Metabolic Syndrome: A
   Systematic Review of Its Efficacy and Mechanism of Action
SO NUTRIENTS
LA English
DT Review
DE metabolic syndrome; Laminaria japonica; atherosclerosis; diabetes;
   obesity; AMPK
ID HIGH-FAT DIET; MOLECULAR-WEIGHT FUCOIDAN; OXIDATIVE STRESS; GUT
   MICROBIOTA; PHYSICOCHEMICAL PROPERTIES; HYPOLIPIDEMIC ACTIVITIES;
   INSULIN-RESISTANCE; LIPID-METABOLISM; BROWN SEAWEEDS; NITRIC-OXIDE
AB Metabolic syndrome (MetS) is a medical condition characterized by abdominal obesity, insulin resistance, high blood pressure, and hyperlipidemia. An increase in the incidence of MetS provokes an escalation in health care costs and a downturn in quality of life. However, there is currently no cure for MetS, and the absence of immediate treatment for MetS has prompted the development of novel therapies. In accordance with recent studies, the brown seaweed Laminaria japonica (LJP) has anti-inflammatory and antioxidant properties, and so forth. LJP contains bioactive compounds used as food globally, and it has been used as a medicine in East Asian countries. We conducted a systematic review to examine whether LJP could potentially be a useful therapeutic drug for MetS. The following databases were searched from initiation to September 2021: PubMed, Web of Science, EMBASE, and Cochrane Central Register of Controlled Trials Library. Clinical trials and in vivo studies evaluating the effects of LJP on MetS were included. LJP reduces the oxidative stress-related lipid mechanisms, inflammatory cytokines and macrophage-related chemokines, muscle cell proliferation, and migration. Bioactive-glucosidase inhibitors reduce diabetic complications, a therapeutic target in obesity and type 2 diabetes. In obesity, LJP increases AMP-activated protein kinase and decreases acetyl-CoA carboxylase. Based on our findings, we suggest that LJP could treat MetS, as it has pharmacological effects on MetS.
C1 [Lee, In-Seon] Kyung Hee Univ, Coll Korean Med, Dept Meridians & Acupoints, Seoul 05253, South Korea.
   [Lee, In-Seon] Kyung Hee Univ, Acupuncture & Meridian Sci Res Ctr, Seoul 02447, South Korea.
   [Ko, Seok-Jae] Kyung Hee Univ, Coll Korean Med, Dept Gastroenterol, Seoul 05253, South Korea.
   [Lee, Yu Na; Lee, Gahyun; Rahman, Hasanur; Kim, Bonglee] Kyung Hee Univ, Coll Korean Med, Seoul 05253, South Korea.
C3 Kyung Hee University; Kyung Hee University; Kyung Hee University; Kyung
   Hee University
RP Kim, B (corresponding author), Kyung Hee Univ, Coll Korean Med, Seoul 05253, South Korea.
EM inseon.lee@khu.ac.kr; kokoko119@khu.ac.kr; unaly@khu.ac.kr;
   dlrkgus177@khu.ac.kr; hasanurrahman.bge@gmail.com; bongleekim@khu.ac.kr
RI Rahman, Hasanur/AAX-4023-2020; Lee, Ho-jeong/S-4934-2019; Kim,
   Bonglee/AAH-9077-2020; Lee, In-Seon/AAM-1252-2020
OI Rahman, MD. Hasanur/0000-0001-9238-3149; Kim,
   Bonglee/0000-0002-8678-156X; Lee, In-Seon/0000-0001-9275-3111
FU National Research Foundation of Korea (NRF) - Korean government (MSIT)
   [2020R1A5A2019413, 2020R1A4A1018598, 2022R1C1C1004937]; Basic Science
   Research Program through the National Research Foundation of Korea (NRF)
   - Ministry of Education [NRF-2020R1I1A2066868]
FX This research was supported by a National Research Foundation of Korea
   (NRF) grant funded by the Korean government (MSIT) (No.
   2022R1C1C1004937), the Basic Science Research Program through the
   National Research Foundation of Korea (NRF) funded by the Ministry of
   Education (NRF-2020R1I1A2066868), and a National Research Foundation of
   Korea (NRF) grant funded by the Korean government (MSIT) (Nos.
   2020R1A5A2019413, 2020R1A4A1018598).
CR Aoe S, 2021, MAR DRUGS, V19, DOI 10.3390/md19070352
   Basatemur GL, 2019, NAT REV CARDIOL, V16, P727, DOI [10.1161/CIRCRESAHA.115.306361, 10.1038/s41569-019-0227-9]
   Batchuluun B, 2022, NAT REV DRUG DISCOV, V21, P283, DOI 10.1038/s41573-021-00367-2
   Boden G, 2002, EUR J CLIN INVEST, V32, P14, DOI 10.1046/j.1365-2362.32.s3.3.x
   Bonetti J, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10040516
   Bu T, 2010, PHYTOTHER RES, V24, P1588, DOI 10.1002/ptr.3139
   Choe SY, 2021, ADV TRADIT MED, V21, P361, DOI 10.1007/s13596-020-00434-w
   Choi WC, 2016, ALGAE-SEOUL, V31, P175, DOI 10.4490/algae.2016.31.6.12
   D'Orazio N, 2012, MAR DRUGS, V10, P604, DOI 10.3390/md10030604
   Dahlén AD, 2022, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.807548
   Duan MM, 2019, INT J BIOL MACROMOL, V121, P996, DOI 10.1016/j.ijbiomac.2018.10.087
   Gabbia D, 2020, MOLECULES, V25, DOI 10.3390/molecules25184182
   Guo H, 2020, PPAR RES, V2020, DOI 10.1155/2020/8889612
   Gupta S, 2011, TRENDS FOOD SCI TECH, V22, P315, DOI 10.1016/j.tifs.2011.03.011
   Han AR, 2020, NUTR RES PRACT, V14, P580, DOI 10.4162/nrp.2020.14.6.580
   Hoffman DJ, 2021, PHYSIOL REV, V101, P739, DOI 10.1152/physrev.00002.2020
   Hossain U, 2020, FOOD CHEM TOXICOL, V145, DOI 10.1016/j.fct.2020.111738
   HOTAMISLIGIL GS, 1994, DIABETES, V43, P1271, DOI 10.2337/diabetes.43.11.1271
   Huang CX, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.794939
   Huang L, 2010, PHARM BIOL, V48, P422, DOI 10.3109/13880200903150435
   Ikeguchi M, 2011, ONCOL LETT, V2, P319, DOI 10.3892/ol.2011.254
   Jang WS, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/492807
   Jia XB, 2014, EXP BIOL MED, V239, P1663, DOI 10.1177/1535370214537751
   Jin DQ, 2004, BIOL PHARM BULL, V27, P1037, DOI 10.1248/bpb.27.1037
   Kang SY, 2018, NUTRIENTS, V10, DOI 10.3390/nu10040491
   Kang YM, 2012, FOOD CHEM TOXICOL, V50, P1166, DOI 10.1016/j.fct.2011.11.026
   Kattoor AJ, 2017, CURR ATHEROSCLER REP, V19, DOI 10.1007/s11883-017-0678-6
   Kim B, 2022, MEDICINE, V101, DOI 10.1097/MD.0000000000028892
   Ko SJ, 2014, J MED FOOD, V17, P76, DOI 10.1089/jmf.2013.3054
   Kola B, 2008, FRONT HORM RES, V36, P198, DOI 10.1159/000115366
   Kumar Sunil, 2011, Pharmacogn Rev, V5, P19, DOI 10.4103/0973-7847.79096
   Lenzen S, 2008, DIABETOLOGIA, V51, P216, DOI 10.1007/s00125-007-0886-7
   Li DY, 2000, CIRCULATION, V101, P2889, DOI 10.1161/01.CIR.101.25.2889
   Li NN, 2020, FOOD FUNCT, V11, P2395, DOI [10.1039/c9fo02994j, 10.1039/C9FO02994J]
   Li QM, 2021, FOOD FUNCT, V12, P5260, DOI [10.1039/d0fo02100h, 10.1039/D0FO02100H]
   Li Xiaodan, 2012, ISRN Endocrinol, V2012, P507462, DOI 10.5402/2012/507462
   Liang ZY, 2016, J ETHNOPHARMACOL, V191, P341, DOI 10.1016/j.jep.2016.06.054
   Liu YX, 2019, J FUNCT FOODS, V58, P44, DOI 10.1016/j.jff.2019.04.051
   Long SH, 2012, INT J MOL SCI, V13, P3354, DOI 10.3390/ijms13033354
   Luan F, 2021, FOOD FUNCT, V12, P4254, DOI [10.1039/d1fo00311a, 10.1039/D1FO00311A]
   Luiking YC, 2010, CURR OPIN CLIN NUTR, V13, P97, DOI 10.1097/MCO.0b013e328332f99d
   Maritim AC, 2003, J BIOCHEM MOL TOXIC, V17, P24, DOI 10.1002/jbt.10058
   Naghipour M, 2021, INT J ENDOCRINOL, V2021, DOI 10.1155/2021/8862456
   Nishimura M, 2019, FUNCT FOODS HEALTH D, V9, P205, DOI 10.31989/ffhd.v9i4.594
   Nishiumi S, 2020, J NUTR SCI VITAMINOL, V66, P185, DOI 10.3177/jnsv.66.185
   Nishiumi S, 2019, FOOD SCI TECHNOL RES, V25, P827, DOI 10.3136/fstr.25.827
   Oh JH, 2016, NUTR RES PRACT, V10, P42, DOI 10.4162/nrp.2016.10.1.42
   Page MJ, 2021, BMJ-BRIT MED J, V372, DOI [10.1136/bmj.n71, 10.1136/bmj.n160]
   Papadopoulou C, 2008, CYTOKINE, V43, P181, DOI 10.1016/j.cyto.2008.05.009
   Park MY, 2009, FOOD SCI BIOTECHNOL, V18, P712
   Peng FH, 2015, INT J BIOL MACROMOL, V81, P926, DOI 10.1016/j.ijbiomac.2015.09.027
   Pollard AE, 2019, NAT METAB, V1, P340, DOI 10.1038/s42255-019-0036-9
   Popovic-Djordjevic JB, 2021, CURR MED CHEM, V28, P4592, DOI 10.2174/0929867328666210325100654
   Ranaweera SS, 2022, J NUTR BIOCHEM, V100, DOI 10.1016/j.jnutbio.2021.108885
   Ritter K, 2016, J MED CHEM, V59, P3579, DOI 10.1021/acs.jmedchem.5b01198
   Rochette L, 2014, BBA-GEN SUBJECTS, V1840, P2709, DOI 10.1016/j.bbagen.2014.05.017
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Shang QS, 2017, J FUNCT FOODS, V28, P138, DOI 10.1016/j.jff.2016.11.002
   Shirosaki M, 2011, ADV FOOD NUTR RES, V64, P199, DOI 10.1016/B978-0-12-387669-0.00015-6
   Sterne JAC, 2019, BMJ-BRIT MED J, V366, DOI 10.1136/bmj.l4898
   Sun N, 2022, J AQUAT FOOD PROD T, V31, P154, DOI 10.1080/10498850.2021.2024313
   Tocaciu S, 2018, INTEGR CANCER THER, V17, P99, DOI 10.1177/1534735416684014
   Unger RH, 2001, DIABETES, V50, pS118, DOI 10.2337/diabetes.50.2007.S118
   Wang X, 2016, INT J CLIN EXP PATHO, V9, P6896
   Wang XX, 2022, NUTRIENTS, V14, DOI 10.3390/nu14020329
   Wang ZQ, 2018, J ETHNOPHARMACOL, V210, P434, DOI 10.1016/j.jep.2017.09.014
   Wijesinghe WAJP, 2011, PHYTOCHEM REV, V10, P431, DOI 10.1007/s11101-011-9214-4
   Wondmkun YT, 2020, DIABET METAB SYND OB, V13, P3611, DOI 10.2147/DMSO.S275898
   Wu ZH, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124480
   Xie L, 2011, PHYTOTHER RES, V25, P1362, DOI 10.1002/ptr.3433
   Xu JG, 2021, PHYTOTHER RES, V35, P2133, DOI 10.1002/ptr.6966
   Yamagishi S, 2011, PHARMACOL RES, V64, P187, DOI 10.1016/j.phrs.2011.05.009
   Yao YJ, 2017, INT J FOOD SCI TECH, V52, P2274, DOI 10.1111/ijfs.13508
   You JS, 2009, NUTR RES PRACT, V3, P307, DOI 10.4162/nrp.2009.3.4.307
   Zelová H, 2013, INFLAMM RES, V62, P641, DOI 10.1007/s00011-013-0633-0
   Zha XQ, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600456
   Zha XQ, 2012, FOOD CHEM, V134, P244, DOI 10.1016/j.foodchem.2012.02.129
   Zhang LH, 2016, SCI REP-UK, V6, DOI 10.1038/srep32649
   Zhang Q, 2021, FOOD FUNCT, V12, P7145, DOI [10.1039/d1fo00218j, 10.1039/D1FO00218J]
   Zhang Q, 2020, FOOD FUNCT, V11, P3256, DOI [10.1039/d0fo00065e, 10.1039/D0FO00065E]
   Zhang YP, 2021, FOOD FUNCT, V12, P587, DOI [10.1039/d0fo02380a, 10.1039/D0FO02380A]
   Zhao X, 2016, THROMB RES, V144, P46, DOI 10.1016/j.thromres.2016.03.008
   Zhao YY, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.632378
   Zheng WY, 2021, INT J BIOL MACROMOL, V187, P811, DOI 10.1016/j.ijbiomac.2021.08.003
NR 84
TC 6
Z9 6
U1 3
U2 24
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2022
VL 14
IS 15
AR 3046
DI 10.3390/nu14153046
PG 25
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 3S8AQ
UT WOS:000839812900001
PM 35893900
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pingitore, A
   Gaggini, M
   Mastorci, F
   Sabatino, L
   Cordiviola, L
   Vassalle, C
AF Pingitore, Alessandro
   Gaggini, Melania
   Mastorci, Francesca
   Sabatino, Laura
   Cordiviola, Linda
   Vassalle, Cristina
TI Metabolic Syndrome, Thyroid Dysfunction, and Cardiovascular Risk: The
   Triptych of Evil
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE metabolic syndrome; thyroid hormones; thyroid dysfunction;
   cardiovascular risk; endothelial dysfunction; atherosclerosis
ID HORMONE RECEPTOR-BETA; BROWN ADIPOSE-TISSUE; SUBCLINICAL HYPOTHYROIDISM;
   OXIDATIVE STRESS; BLOOD-PRESSURE; INSULIN-RESISTANCE; PROVISIONAL
   REPORT; MORTALITY; TRIIODOTHYRONINE; HYPERTHYROIDISM
AB The triad formed by thyroid dysfunction, metabolic syndrome (MetS), and cardiovascular (CV) risk forms a network with many connections that aggravates health outcomes. Thyroid hormones (THs) play an important role in glucose and lipid metabolism and hemodynamic regulation at the molecular level. It is noteworthy that a bidirectional association between THs and MetS and their components likely exists as MetS leads to thyroid dysfunction, whereas thyroid alterations may cause a higher incidence of MetS. Thyroid dysfunction increases insulin resistance, the circulating levels of lipids, in particular LDL-C, VLDL-C, and triglycerides, and induces endothelial dysfunction. Furthermore, THs are important regulators of both white and brown adipose tissue. Moreover, the pathophysiological relationship between MetS and TH dysfunction is made even tighter considering that these conditions are usually associated with inflammatory activation and increased oxidative stress. Therefore, the role of THs takes place starting from the molecular level, then manifesting itself at the clinical level, through an increased risk of CV events in the general population as well as in patients with heart failure or acute myocardial infarction. Thus, MetS is frequently associated with thyroid dysfunction, which supports the need to assess thyroid function in this group, and when clinically indicated, to correct it to maintain euthyroidism. However, there are still several critical points to be further investigated both at the molecular and clinical level, in particular considering the need to treat subclinical dysthyroidism in MetS patients.
C1 [Pingitore, Alessandro; Gaggini, Melania; Mastorci, Francesca; Sabatino, Laura] CNR, Clin Physiol Inst, I-56124 Pisa, Italy.
   [Cordiviola, Linda] Pisa Univ, Dept Pharm, I-56126 Pisa, Italy.
   [Vassalle, Cristina] Fdn G Monasterio, Reg Toscana, I-56124 Pisa, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR); University of Pisa
RP Pingitore, A (corresponding author), CNR, Clin Physiol Inst, I-56124 Pisa, Italy.
EM alessandro.pingitore@cnr.it; melania.gaggini@cnr.it;
   francesca.mastorci@cnr.it; laura.sabatino@cnr.it;
   l.cordiviola1@studenti.unipi.it; cricca@ftgm.it
RI Pingitore, Alessandro/K-1843-2018; Sabatino, Laura/AAX-8985-2020;
   Gaggini, Melania/C-9379-2017
OI Gaggini, Melania/0000-0002-6311-502X; VASSALLE,
   CRISTINA/0000-0003-3438-6450; Sabatino, Laura/0000-0002-9283-5042
FX This research received no external funding.
CR Aboonabi A, 2019, J HUM HYPERTENS, V33, P844, DOI 10.1038/s41371-019-0273-0
   Aksoy S, 2014, J CARDIOL, V64, P194, DOI 10.1016/j.jjcc.2014.01.002
   Al-Daghri NM, 2016, INT J CLIN EXP MED, V9, P13086
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Albrecht E, 2020, MOL METAB, V34, P124, DOI 10.1016/j.molmet.2020.01.016
   Alwan H, 2024, ENDOCRINE, V84, P320, DOI 10.1007/s12020-023-03503-7
   Angelone T, 2024, ANTIOXID REDOX SIGN, V40, P369, DOI 10.1089/ars.2023.0285
   Anyetei-Anum CS, 2018, J ENDOCRINOL, V237, pR19, DOI 10.1530/JOE-17-0708
   Attiq A, 2024, EUR J PHARMACOL, V966, DOI 10.1016/j.ejphar.2024.176338
   Baldissarelli J, 2020, MOL CELL ENDOCRINOL, V499, DOI 10.1016/j.mce.2019.110594
   Balkau B, 1999, DIABETIC MED, V16, P442
   Bano A, 2017, CIRC RES, V121, P1392, DOI 10.1161/CIRCRESAHA.117.311603
   Benstoem C, 2015, NUTRIENTS, V7, P3094, DOI 10.3390/nu7053094
   Bergler-Klein J, 2019, WIEN KLIN WOCHENSCHR, V131, P180, DOI 10.1007/s00508-018-1435-8
   Berta E, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00482
   Bianco AC, 1998, ENDOCRINOLOGY, V139, P571, DOI 10.1210/en.139.2.571
   Bianco AC, 2013, LANCET DIABETES ENDO, V1, P250, DOI 10.1016/S2213-8587(13)70069-X
   Biondi B, 2024, NUTRIENTS, V16, DOI 10.3390/nu16010087
   Cappola AR, 2006, JAMA-J AM MED ASSOC, V295, P1033, DOI 10.1001/jama.295.9.1033
   Carrillo-Sepúlveda MA, 2010, CARDIOVASC RES, V85, P560, DOI 10.1093/cvr/cvp304
   Chang E, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112806
   Chen TF, 2024, HORM METAB RES, V56, P435, DOI 10.1055/a-2196-3764
   Cheng SY, 2010, ENDOCR REV, V31, P139, DOI 10.1210/er.2009-0007
   Christoffolete MA, 2004, DIABETES, V53, P577, DOI 10.2337/diabetes.53.3.577
   Chubb SAP, 2005, J CLIN ENDOCR METAB, V90, P5317, DOI 10.1210/jc.2005-0298
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cohen P, 2015, DIABETES, V64, P2346, DOI 10.2337/db15-0318
   Dabravolski SA, 2023, BIOMEDICINES, V11, DOI 10.3390/biomedicines11072010
   Dardano A, 2006, THYROID, V16, P200, DOI 10.1089/thy.2006.16.200
   Das D, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1221438
   de Silva T, 2020, CURR HYPERTENS REP, V22, DOI 10.1007/s11906-020-01108-3
   Demircan K, 2024, TRENDS ENDOCRIN MET, V35, P781, DOI 10.1016/j.tem.2024.03.004
   Demirhan S, 2023, ACTA ENDOCRINOL-BUCH, V19, P333, DOI 10.4183/aeb.2023.333
   Di Carli MF, 2011, J NUCL MED, V52, P1369, DOI 10.2967/jnumed.110.082883
   Dodd GT, 2015, CELL, V160, P88, DOI 10.1016/j.cell.2014.12.022
   Duntas LH, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00511
   Eom YS, 2022, DIABETES METAB J, V46, P239, DOI 10.4093/dmj.2022.0013
   Fenizia S, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms242317123
   Ferrannini E, 2017, AM J PHYSIOL-ENDOC M, V312, pE429, DOI 10.1152/ajpendo.00464.2016
   Franklin Stanley S., 2006, Metabolic Syndrome and Related Disorders, V4, P287, DOI 10.1089/met.2006.4.287
   Gaggini M, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23052719
   Garasto S, 2017, MECH AGEING DEV, V165, P98, DOI 10.1016/j.mad.2017.03.002
   Garber JR, 2012, ENDOCR PRACT, V18, P989, DOI 10.4158/EP12280.GL
   García-Solís P, 2018, ENDOKRYNOL POL, V69, P292, DOI 10.5603/EP.2018.0032
   Gluvic ZM, 2020, BIOMED PHARMACOTHER, V124, DOI 10.1016/j.biopha.2020.109881
   Gorini F, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11061188
   Gorini F, 2021, MOLECULES, V26, DOI 10.3390/molecules26237084
   Goulart-Silva F, 2013, EXP CLIN ENDOCR DIAB, V121, P14, DOI 10.1055/s-0032-1327598
   Gullberg H, 2002, MOL ENDOCRINOL, V16, P1767, DOI 10.1210/me.2002-0009
   Guzik TJ, 2020, CARDIOVASC RES, V116, P1666, DOI 10.1093/cvr/cvaa106
   Hak AE, 2000, ANN INTERN MED, V132, P270, DOI 10.7326/0003-4819-132-4-200002150-00004
   Iervasi G, 2003, CIRCULATION, V107, P708, DOI 10.1161/01.CIR.0000048124.64204.3F
   Iervasi G, 2007, ARCH INTERN MED, V167, P1526, DOI 10.1001/archinte.167.14.1526
   Iwen KA, 2013, EUR THYROID J, V2, P83, DOI 10.1159/000351249
   Jabbar A, 2017, NAT REV CARDIOL, V14, P39, DOI 10.1038/nrcardio.2016.174
   Johansson L, 2005, P NATL ACAD SCI USA, V102, P10297, DOI 10.1073/pnas.0504379102
   Kalra S, 2021, INT J ENDOCRINOL, V2021, DOI 10.1155/2021/9641846
   Kaminski G, 2012, THYROID, V22, P454, DOI 10.1089/thy.2010.0333
   Kenessey A, 2006, J BIOL CHEM, V281, P20666, DOI 10.1074/jbc.M512671200
   Kilic Ismail Dogu, 2013, Indian J Endocrinol Metab, V17, P271, DOI 10.4103/2230-8210.109708
   La Carrubba S, 2013, J CARDIOVASC ECHOGR, V23, P96, DOI 10.4103/2211-4122.127410
   LIN FT, 1994, P NATL ACAD SCI USA, V91, P8757, DOI 10.1073/pnas.91.19.8757
   Liu YJ, 2023, ENDOCRINE, V79, P459, DOI 10.1007/s12020-022-03254-x
   Makhoul E, 2022, CUREUS J MED SCIENCE, V14, DOI 10.7759/cureus.27438
   Malekmohammad K, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.707529
   Mancini A, 2013, INT J MOL SCI, V14, P23893, DOI 10.3390/ijms141223893
   Manolis AA, 2020, TRENDS CARDIOVAS MED, V30, P57, DOI 10.1016/j.tcm.2019.02.011
   Martin SS, 2024, CIRCULATION, V149, pE347, DOI 10.1161/CIR.0000000000001209
   Martinez B, 2017, PHYSIOLOGY, V32, P141, DOI 10.1152/physiol.00018.2016
   Masenga SK, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24097898
   Mastorci F, 2020, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00927
   Masullo LF, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00655
   Maximus PS, 2020, CYTOKINE, V133, DOI 10.1016/j.cyto.2020.155144
   McAllister RM, 2000, AM J PHYSIOL-ENDOC M, V279, pE252, DOI 10.1152/ajpendo.2000.279.2.E252
   Mendez DA, 2021, PHYSIOL REP, V9, DOI 10.14814/phy2.14858
   Min CY, 2024, CARDIOVASC DIABETOL, V23, DOI 10.1186/s12933-024-02225-y
   Mourouzis I, 2012, MOL CELL BIOCHEM, V363, P235, DOI 10.1007/s11010-011-1175-9
   Naseem Z, 2019, J BIOL REG HOMEOS AG, V33, P1891, DOI 10.23812/19-334-L
   Niknam Nasmi, 2016, Adv Biomed Res, V5, P38, DOI 10.4103/2277-9175.178783
   O'Brien JM, 2024, AM J CARDIOL, V219, P25, DOI 10.1016/j.amjcard.2024.02.025
   O'Hearn M, 2022, J AM COLL CARDIOL, V80, P138, DOI 10.1016/j.jacc.2022.04.046
   Obregon MJ, 2008, THYROID, V18, P185, DOI 10.1089/thy.2007.0254
   Ortega FJ, 2012, INT J OBESITY, V36, P320, DOI 10.1038/ijo.2011.101
   Pantos C, 2003, MOL CELL BIOCHEM, V242, P173, DOI 10.1023/A:1021162417490
   Parle JV, 2001, LANCET, V358, P861, DOI 10.1016/S0140-6736(01)06067-6
   Passino C, 2009, J CARD FAIL, V15, P35, DOI 10.1016/j.cardfail.2008.08.008
   Pedreanez Adriana, 2024, Endocr Regul, V58, P57, DOI 10.2478/enr-2024-0007
   Peng CCH, 2024, JAMA NETW OPEN, V7, DOI 10.1001/jamanetworkopen.2024.0904
   Pierucci F, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms241310548
   Pingitore A, 2005, AM J MED, V118, P132, DOI 10.1016/j.amjmed.2004.07.052
   Pingitore A, 2019, AM J CARDIOL, V123, P905, DOI 10.1016/j.amjcard.2018.12.020
   Pingitore A, 2016, HEART FAIL REV, V21, P391, DOI 10.1007/s10741-016-9545-8
   Pingitore A, 2015, NUTRITION, V31, P916, DOI 10.1016/j.nut.2015.02.005
   Pinho JD Jr, 2023, INT J INFLAMM, V2023, DOI 10.1155/2023/5810157
   Pleic N, 2023, J CLIN ENDOCR METAB, V108, P3190, DOI 10.1210/clinem/dgad371
   Prisant L Michael, 2006, J Clin Hypertens (Greenwich), V8, P596, DOI 10.1111/j.1524-6175.2006.05180.x
   Purohit Purvi, 2013, N Am J Med Sci, V5, P195, DOI 10.4103/1947-2714.109187
   RABELO R, 1995, ENDOCRINOLOGY, V136, P1003, DOI 10.1210/en.136.3.1003
   Rauf A, 2024, FOOD SCI NUTR, V12, P675, DOI 10.1002/fsn3.3784
   Razvi S, 2018, J AM COLL CARDIOL, V71, P1781, DOI 10.1016/j.jacc.2018.02.045
   Razvi S, 2010, J CLIN ENDOCR METAB, V95, P1734, DOI 10.1210/jc.2009-1749
   Ricquier Daniel, 2011, Front Endocrinol (Lausanne), V2, P85, DOI 10.3389/fendo.2011.00085
   Riis ALD, 2002, J CLIN ENDOCR METAB, V87, P4747, DOI 10.1210/jc.2002-020174
   Riis KR, 2023, EUR THYROID J, V12, DOI 10.1530/ETJ-23-0167
   Ripoli A, 2005, J AM COLL CARDIOL, V45, P439, DOI 10.1016/j.jacc.2004.10.044
   Rosen ED, 2014, CELL, V156, P20, DOI 10.1016/j.cell.2013.12.012
   Ruchala M, 2014, PEPTIDES, V60, P51, DOI 10.1016/j.peptides.2014.07.021
   Sabatino L, 2021, ENDOCRINOL METAB, V36, P952, DOI 10.3803/EnM.2021.1198
   Safari S, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1306470
   Safarpour P, 2020, BMC FAM PRACT, V21, DOI 10.1186/s12875-020-1096-3
   Sanesi L, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24044129
   Sano H, 2003, J BIOL CHEM, V278, P14599, DOI 10.1074/jbc.C300063200
   Santini F, 2014, EUR J ENDOCRINOL, V171, pR137, DOI 10.1530/EJE-14-0067
   Sanyal Debmalya, 2016, Indian J Endocrinol Metab, V20, P554, DOI 10.4103/2230-8210.183454
   SAWIN CT, 1994, NEW ENGL J MED, V331, P1249, DOI 10.1056/NEJM199411103311901
   Shirzad N, 2022, INT J PREVENTIVE MED, V13, DOI 10.4103/ijpvm.IJPVM_607_20
   Su X, 2022, BOSNIAN J BASIC MED, V22, P326, DOI 10.17305/bjbms.2021.6606
   Taniguchi CM, 2006, NAT REV MOL CELL BIO, V7, P85, DOI 10.1038/nrm1837
   Teixeira PDD, 2020, THER ADV ENDOCRINOL, V11, DOI 10.1177/2042018820917869
   Tran Hien, 2003, Sci STKE, V2003, pRE5, DOI 10.1126/stke.2003.172.re5
   Trivieri MG, 2006, P NATL ACAD SCI USA, V103, P6043, DOI 10.1073/pnas.0601072103
   Trost SU, 2000, ENDOCRINOLOGY, V141, P3057, DOI 10.1210/en.141.9.3057
   Tudoran C, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10071519
   Tuzcu A, 2005, ENDOCR J, V52, P89, DOI 10.1507/endocrj.52.89
   Vargas F, 2006, EUR J ENDOCRINOL, V154, P197, DOI 10.1530/eje.1.02093
   Vassalle C, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.722912
   Vassalle C, 2020, MOLECULES, V25, DOI 10.3390/molecules25112653
   Verga Falzacappa C, 2006, J CELL PHYSIOL, V206, P309, DOI 10.1002/jcp.20460
   Völzke H, 2006, J HYPERTENS, V24, P1947
   Völzke H, 2009, EUR J ENDOCRINOL, V161, P615, DOI 10.1530/EJE-09-0376
   Vyakaranam Sapna, 2014, Int J Health Sci Res, V4, P147
   Walczak K, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18189434
   Walsh JP, 2005, ARCH INTERN MED, V165, P2467, DOI 10.1001/archinte.165.21.2467
   Wang PZ, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1263853
   Warakomski J, 2018, INT J ENDOCRINOL, V2018, DOI 10.1155/2018/4921803
   Waring AC, 2012, CLIN ENDOCRINOL, V76, P911, DOI 10.1111/j.1365-2265.2011.04328.x
   Wu ZY, 2022, J CLIN ENDOCR METAB, V107, pE2365, DOI 10.1210/clinem/dgac110
   Xu YN, 2023, LANCET DIABETES ENDO, V11, P743, DOI 10.1016/S2213-8587(23)00227-9
   Yan BX, 2024, FRONT BIOSCI-LANDMRK, V29, DOI 10.31083/j.fbl2904161
   Yanai H, 2008, NUTR J, V7, DOI 10.1186/1475-2891-7-10
   Zúñiga D, 2024, CUREUS J MED SCIENCE, V16, DOI 10.7759/cureus.52512
NR 144
TC 3
Z9 3
U1 2
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2024
VL 25
IS 19
AR 10628
DI 10.3390/ijms251910628
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA I7Y7R
UT WOS:001332382200001
PM 39408957
OA gold
DA 2025-06-11
ER

PT J
AU Medina-Julio, D
   Ramírez-Mejía, MM
   Cordova-Gallardo, J
   Peniche-Luna, E
   Cantú-Brito, C
   Méndez-Sánchez, N
AF Medina-Julio, David
   Ramirez-Mejia, Mariana M.
   Cordova-Gallardo, Jacqueline
   Peniche-Luna, Emilio
   Cantu-Brito, Carlos
   Mendez-Sanchez, Nahum
TI From Liver to Brain: How MAFLD/MASLD Impacts Cognitive Function
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE Abdominal Obesity Metabolic Syndrome; Cognitive Dysfunction; Insulin
   Resistance; Metabolic Syndrome; Non-Alcoholic Fatty Liver Disease;
   Oxidative Stress
ID FATTY LIVER; INSULIN-RESISTANCE; METABOLIC SYNDROME; GUT MICROBIOTA;
   DISEASE; INFLAMMATION; FRUCTOSE; STRESS; AXIS; ASSOCIATION
AB Metabolic dysfunction -associated fatty liver disease or metabolic dysfunction -associated steatotic liver disease (MAFLD/MASLD), is a common chronic liver condition affecting a substantial global population. Beyond its primary impact on liver function, MAFLD/MASLD is associated with a myriad of extrahepatic manifestations, including cognitive impairment. The scope of cognitive impairment within the realm of MAFLD/MASLD is a matter of escalating concern. Positioned as an intermediate stage between the normal aging process and the onset of dementia, cognitive impairment manifests as a substantial challenge associated with this liver condition. Insights from studies underscore the presence of compromised executive function and a global decline in cognitive capabilities among individuals identified as being at risk of progressing to liver fibrosis. Importantly, this cognitive impairment transcends mere association with metabolic factors, delving deep into the intricate pathophysiology characterizing MAFLD/MASLD. The multifaceted nature of cognitive impairment in the context of MAFLD/MASLD is underlined by a spectrum of factors, prominently featuring insulin resistance, lipotoxicity, and systemic inflammation as pivotal contributors. These factors interplay within the intricate landscape of MAFLD/MASLD, fostering a nuanced understanding of the links between hepatic health and cognitive function. By synthesizing the available evidence, exploring potential mechanisms, and assessing clinical implications, the overarching aim of this review is to contribute to a more complete understanding of the impact of MAFLD/MASLD on cognitive function.
C1 [Medina-Julio, David] Gen Hosp Dr Manuel Gea Gonzalez, Dept Internal Med, Mexico City, Mexico.
   [Cordova-Gallardo, Jacqueline; Cantu-Brito, Carlos; Mendez-Sanchez, Nahum] Univ Nacl Autonoma Mexico, Fac Med, Mexico City, Mexico.
   [Ramirez-Mejia, Mariana M.; Mendez-Sanchez, Nahum] Med Sur Clin & Fdn, Liver Unit, Mexico City, Mexico.
   [Ramirez-Mejia, Mariana M.] Univ Nacl Autonoma Mexico, Fac Med, Plan Combined Studies Med, Mexico City, Mexico.
   [Cordova-Gallardo, Jacqueline] Gen Hosp Dr Manuel Gea Gonzalez, Dept Hepatol, Serv Surg & Obes Clin, Mexico City, Mexico.
   [Peniche-Luna, Emilio] Univ Nacl Autonoma Mexico, Fac Med, High Acad Performance Program PAEA, Mexico City, Mexico.
   [Cantu-Brito, Carlos] Natl Inst Med Sci & Nutr Salvador Zubiran, Dept Neurol, Mexico City, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma
   de Mexico; Universidad Nacional Autonoma de Mexico
RP Méndez-Sánchez, N (corresponding author), Univ Nacl Autonoma Mexico, Fac Med, Mexico City, Mexico.; Méndez-Sánchez, N (corresponding author), Med Sur Clin & Fdn, Liver Unit, Mexico City, Mexico.
RI CANTU BRITO, CARLOS/LZH-6832-2025
FU Consejo Nacional de Humanidades, Ciencias y Tecnologias (CONAHCYT)
FX The scholarships granted by Consejo Nacional de Humanidades, Ciencias y
   Tecnologias (CONAHCYT) made it possible for David Medina-Julio and
   Mariana M Ramirez-Mejia to undertake post-graduate studies, enriching
   their academic and professional development.
CR Abbasi F, 2023, PSYCHONEUROENDOCRINO, V147, DOI 10.1016/j.psyneuen.2022.105944
   Abdeldyem SM, 2017, J CLIN LIPIDOL, V11, P915, DOI 10.1016/j.jacl.2017.04.115
   Abdelmalek MF, 2010, HEPATOLOGY, V51, P1961, DOI 10.1002/hep.23535
   Airaghi L, 2018, ATHEROSCLEROSIS, V268, P27, DOI 10.1016/j.atherosclerosis.2017.11.012
   Ali W, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9030667
   Arrese M, 2016, DIGEST DIS SCI, V61, P1294, DOI 10.1007/s10620-016-4049-x
   Asadi A, 2022, J CLIN LAB ANAL, V36, DOI 10.1002/jcla.24420
   Athauda D, 2018, NEUROPHARMACOLOGY, V136, P260, DOI 10.1016/j.neuropharm.2017.09.023
   Balp MM, 2019, JHEP REP, V1, P154, DOI 10.1016/j.jhepr.2019.05.009
   Barzegarzadeh B, 2021, NEUROTOX RES, V39, P815, DOI 10.1007/s12640-020-00310-0
   Buzzetti E, 2016, METABOLISM, V65, P1038, DOI 10.1016/j.metabol.2015.12.012
   Cahenzli J, 2013, IMMUNOLOGY, V138, P12, DOI 10.1111/j.1365-2567.2012.03624.x
   Celikbilek A, 2018, EUR J GASTROEN HEPAT, V30, P944, DOI 10.1097/MEG.0000000000001131
   Chan KE, 2022, J CLIN ENDOCR METAB, V107, P2691, DOI 10.1210/clinem/dgac321
   Chaudhry TS, 2023, J CLIN MED, V12, DOI 10.3390/jcm12165231
   Cheon SY, 2022, CELL BIOSCI, V12, DOI 10.1186/s13578-022-00836-0
   Cotter TG, 2020, GASTROENTEROLOGY, V158, P1851, DOI 10.1053/j.gastro.2020.01.052
   Craft S, 2004, LANCET NEUROL, V3, P169, DOI 10.1016/S1474-4422(04)00681-7
   Cui QN, 2022, BRIT J PHARMACOL, V179, P715, DOI 10.1111/bph.15683
   Cui Y, 2022, J MAGN RESON IMAGING, V56, P1621, DOI 10.1002/jmri.28358
   Cushman M, 2023, PLOS ONE, V18, DOI 10.1371/journal.pone.0282633
   Daneman R, 2015, CSH PERSPECT BIOL, V7, DOI 10.1101/cshperspect.a020412
   Ding JH, 2020, WORLD J GASTROENTERO, V26, P6141, DOI 10.3748/wjg.v26.i40.6141
   Duffy CM, 2019, NEUROBIOL LEARN MEM, V157, P41, DOI 10.1016/j.nlm.2018.11.008
   Dye L, 2017, P NUTR SOC, V76, P443, DOI 10.1017/S0029665117002014
   Elliott C, 2013, DIGEST DIS SCI, V58, P2383, DOI 10.1007/s10620-013-2657-2
   Engin AB, 2017, ADV EXP MED BIOL, V960, P197, DOI 10.1007/978-3-319-48382-5_8
   Eslam M, 2020, LANCET GASTROENTEROL, V5, P713, DOI 10.1016/S2468-1253(20)30090-X
   Eslam M, 2020, NAT REV GASTRO HEPAT, V17, P40, DOI 10.1038/s41575-019-0212-0
   Eslami H, 2014, NEUROSCI LETT, V558, P31, DOI 10.1016/j.neulet.2013.10.057
   Flores-Cordero JA, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23095202
   Forsythe P, 2014, ADV EXP MED BIOL, V817, P115, DOI 10.1007/978-1-4939-0897-4_5
   Foster JA, 2017, NEUROBIOL STRESS, V7, P124, DOI 10.1016/j.ynstr.2017.03.001
   Fricker ZP, 2019, CLIN GASTROENTEROL H, V17, P1157, DOI 10.1016/j.cgh.2018.11.037
   Ge X, 2023, FUTURE FOODS, V8, DOI 10.1016/j.fufo.2023.100256
   Gehrke N, 2020, GASTROENTEROLOGY, V158, P1929, DOI 10.1053/j.gastro.2020.02.020
   Gejl M, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-17718-y
   Geng ZH, 2022, FRONT AGING NEUROSCI, V14, DOI 10.3389/fnagi.2022.810483
   George ES, 2022, BMC GERIATR, V22, DOI 10.1186/s12877-021-02721-w
   Guzman-Martinez L, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.01008
   Gwak MG, 2021, IMMUNE NETW, V21
   Hamed SA, 2017, EXPERT REV CLIN PHAR, V10, P409, DOI 10.1080/17512433.2017.1293521
   Herman JP, 2016, COMPR PHYSIOL, V6, P603, DOI 10.1002/cphy.c150015
   Hsu CL, 2023, NAT REV MICROBIOL, V21, P719, DOI 10.1038/s41579-023-00904-3
   Iadecola C, 2019, CIRC RES, V124, P1025, DOI 10.1161/CIRCRESAHA.118.313260
   Jeong MY, 2019, NEUROSCI LETT, V698, P51, DOI 10.1016/j.neulet.2019.01.006
   Jongsiriyanyong S, 2018, AM J ALZHEIMERS DIS, V33, P500, DOI 10.1177/1533317518791401
   Kang S, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-16788-x
   Kaya E, 2022, J CLIN TRANSL HEPATO, V10, P329, DOI 10.14218/JCTH.2021.00178
   Kjærgaard K, 2021, J CLIN MED, V10, DOI 10.3390/jcm10040673
   Kopp KO, 2022, PHARMACOL RES, V186, DOI 10.1016/j.phrs.2022.106550
   Krishnan S, 2018, CELL REP, V23, P1099, DOI 10.1016/j.celrep.2018.03.109
   Leigh SJ, 2020, BBA-MOL BASIS DIS, V1866, DOI 10.1016/j.bbadis.2020.165767
   Li DD, 2022, AM J CLIN NUTR, V116, P230, DOI 10.1093/ajcn/nqac074
   Li H, 2018, EUR J NEUROL, V25, P577, DOI 10.1111/ene.13556
   Li QX, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.721198
   Li SR, 2023, NUTRIENTS, V15, DOI 10.3390/nu15173728
   Liang YB, 2022, J CLIN ENDOCR METAB, V107, P88, DOI 10.1210/clinem/dgab641
   Liu YL, 2019, LIFE SCI, V233, DOI 10.1016/j.lfs.2019.116707
   Lombardi R, 2019, DIGEST LIVER DIS, V51, P1214, DOI 10.1016/j.dld.2019.05.015
   Ma DL, 2019, BRAIN RES, V1714, P126, DOI 10.1016/j.brainres.2019.02.030
   Ma L, 2023, NEUROPSYCHOBIOLOGY, V82, P247, DOI 10.1159/000533131
   Martí A, 2019, NUTR HOSP, V36, P939, DOI 10.20960/nh.02496
   Mayer EA, 2022, ANNU REV MED, V73, P439, DOI 10.1146/annurev-med-042320-014032
   Mázala-de-Oliveira T, 2023, BIOMOLECULES, V13, DOI 10.3390/biom13101504
   McEwen BS, 2016, NEUROPSYCHOPHARMACOL, V41, P3, DOI 10.1038/npp.2015.171
   Mendez-Sanchez N, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19072034
   Miller AA, 2014, BRAIN BEHAV IMMUN, V42, P10, DOI 10.1016/j.bbi.2014.04.001
   Misiak B, 2012, BRAIN RES BULL, V89, P144, DOI 10.1016/j.brainresbull.2012.08.003
   Mohammed SK, 2020, PHYSIOL BEHAV, V214, DOI 10.1016/j.physbeh.2019.112762
   Moretti R, 2019, ANN HEPATOL, V18, P563, DOI 10.1016/j.aohep.2019.04.007
   Mou Y, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.796288
   Mowat AM, 2003, NAT REV IMMUNOL, V3, P331, DOI 10.1038/nri1057
   Muller PA, 2020, NATURE, V583, P441, DOI 10.1038/s41586-020-2474-7
   Narayanan S, 2016, IMMUNE NETW, V16, P147, DOI 10.4110/in.2016.16.3.147
   Osadchiy V, 2019, CLIN GASTROENTEROL H, V17, P322, DOI 10.1016/j.cgh.2018.10.002
   Pal SC, 2023, WORLD J GASTROENTERO, V29, P3999, DOI 10.3748/wjg.v29.i25.3999
   Pal SC, 2022, HORM-INT J ENDOCRINO, V21, P573, DOI 10.1007/s42000-022-00391-w
   Petersen RC, 2011, NEW ENGL J MED, V364, P2227, DOI 10.1056/NEJMcp0910237
   Petta S, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000003446
   Pipitone RM, 2023, THER ADV ENDOCRINOL, V14, DOI 10.1177/20420188221145549
   Qin JW, 2021, HYPERTENS RES, V44, P1251, DOI 10.1038/s41440-021-00704-3
   Rivera DS, 2018, MOL NEUROBIOL, V55, P9169, DOI 10.1007/s12035-018-0969-0
   Robea MA, 2023, MEDICINA-LITHUANIA, V59, DOI 10.3390/medicina59091614
   Sa-Nguanmoo P, 2018, BIOMED PHARMACOTHER, V97, P1663, DOI 10.1016/j.biopha.2017.12.021
   Sa-Nguanmoo P, 2017, TOXICOL APPL PHARM, V333, P43, DOI 10.1016/j.taap.2017.08.005
   Saiyasit N, 2020, NUTRITION, V69, DOI 10.1016/j.nut.2019.110576
   Samson SL, 2014, ENDOCRIN METAB CLIN, V43, P1, DOI 10.1016/j.ecl.2013.09.009
   Schulingkamp RJ, 2000, NEUROSCI BIOBEHAV R, V24, P855, DOI 10.1016/S0149-7634(00)00040-3
   Sellmann C, 2015, J NUTR BIOCHEM, V26, P1183, DOI 10.1016/j.jnutbio.2015.05.011
   Seo SW, 2016, NEUROLOGY, V86, P1136, DOI 10.1212/WNL.0000000000002498
   Smith Sean M, 2006, Dialogues Clin Neurosci, V8, P383
   Song Q, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10030524
   Stavrinou PS, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020325
   Sun DQ, 2021, METABOLISM, V115, DOI 10.1016/j.metabol.2020.154433
   Tena-Garitaonaindia M, 2022, PHARMACOL RES, V177, DOI 10.1016/j.phrs.2022.106056
   Trauner M, 2010, BBA-MOL CELL BIOL L, V1801, P299, DOI 10.1016/j.bbalip.2009.10.007
   Tuttolomondo A, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0670-7
   Ungvari Z, 2021, NAT REV NEPHROL, V17, P639, DOI 10.1038/s41581-021-00430-6
   Vadini F, 2021, NUTR METAB CARDIOVAS, V31, P2685, DOI 10.1016/j.numecd.2021.05.027
   Valencia-Rodríguez A, 2019, ANN TRANSL MED, V7, DOI 10.21037/atm.2019.11.13
   Vasiljevic A, 2014, EUR J NUTR, V53, P1393, DOI 10.1007/s00394-013-0641-4
   Vieira JR, 2011, NEUROEPIDEMIOLOGY, V37, P153, DOI 10.1159/000332208
   Wang JJ, 2023, CELLS-BASEL, V12, DOI 10.3390/cells12050793
   Wasilewska N, 2021, CLIN EXP HEPATOL, V7, P1, DOI 10.5114/ceh.2021.104441
   Weinstein AA, 2018, PSYCHOSOMATICS, V59, P567, DOI 10.1016/j.psym.2018.06.001
   Weinstein G, 2019, LIVER INT, V39, P1713, DOI 10.1111/liv.14161
   Weinstein G, 2018, JAMA NEUROL, V75, P97, DOI 10.1001/jamaneurol.2017.3229
   Yan MY, 2023, SIGNAL TRANSDUCT TAR, V8, DOI 10.1038/s41392-023-01673-4
   Yan WH, 2019, LIFE SCI, V231, DOI 10.1016/j.lfs.2019.116566
   Yang J, 2022, FRONT MOL NEUROSCI, V15, DOI 10.3389/fnmol.2022.1013933
   Yonamine CY, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms242216480
   Yoo BB, 2017, IMMUNITY, V46, P910, DOI 10.1016/j.immuni.2017.05.011
   Younossi Z, 2018, NAT REV GASTRO HEPAT, V15, P11, DOI 10.1038/nrgastro.2017.109
   Yu Q, 2022, J CLIN TRANSL HEPATO, V10, P1034, DOI 10.14218/JCTH.2021.00490
   Zhao Y, 2022, EXP THER MED, V24, DOI 10.3892/etm.2022.11366
   Zheng DP, 2020, CELL RES, V30, P492, DOI 10.1038/s41422-020-0332-7
NR 117
TC 15
Z9 15
U1 3
U2 7
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
EI 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD MAR 18
PY 2024
VL 30
AR e943417
DI 10.12659/MSM.943417
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA PY9F9
UT WOS:001217750300001
PM 38282346
OA Green Published
DA 2025-06-11
ER

PT J
AU Senaphan, K
   Kukongviriyapan, U
   Sangartit, W
   Pakdeechote, P
   Pannangpetch, P
   Prachaney, P
   Greenwald, SE
   Kukongviriyapan, V
AF Senaphan, Ketmanee
   Kukongviriyapan, Upa
   Sangartit, Weerapon
   Pakdeechote, Poungrat
   Pannangpetch, Patchareewan
   Prachaney, Parichat
   Greenwald, Stephen E.
   Kukongviriyapan, Veerapol
TI Ferulic Acid Alleviates Changes in a Rat Model of Metabolic Syndrome
   Induced by High-Carbohydrate, High-Fat Diet
SO NUTRIENTS
LA English
DT Article
ID ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; OXIDATIVE STRESS; RICE
   BRAN; TETRAHYDROCURCUMIN; PATHOPHYSIOLOGY; BIOCHEMISTRY; CHEMISTRY;
   CURCUMIN; GLUCOSE
AB Metabolic syndrome is a cluster of metabolic abnormalities characterized by obesity, insulin resistance, hypertension and dyslipidemia. Ferulic acid (FA) is the major phenolic compound found in rice oil and various fruits and vegetables. In this study, we examined the beneficial effects of FA in minimizing insulin resistance, vascular dysfunction and remodeling in a rat model of high-carbohydrate, high-fat diet-induced metabolic changes, which is regarded as an analogue of metabolic syndrome (MS) in man. Male Sprague-Dawley rats were fed a high carbohydrate, high fat (HCHF) diet and 15% fructose in drinking water for 16 weeks, where control rats were fed with standard chow diet and tap water. FA (30 or 60 mg/kg) was orally administered to the HCHF and control rats during the last six weeks of the study. We observed that FA significantly improved insulin sensitivity and lipid profiles, and reduced elevated blood pressure, compared to untreated controls (p < 0.05). Moreover, FA also improved vascular function and prevented vascular remodeling of mesenteric arteries. The effects of FA in HCHF-induced MS may be realized through suppression of oxidative stress by down-regulation of p47phox, increased nitric oxide (NO) bioavailability with up-regulation of endothelial nitric oxide synthase (eNOS) and suppression of tumor necrosis factor-alpha (TNF-alpha). Our results suggest that supplementation of FA may have health benefits by minimizing the cardiovascular complications of MS and alleviating its symptoms.
C1 [Senaphan, Ketmanee; Kukongviriyapan, Upa; Sangartit, Weerapon; Pakdeechote, Poungrat] Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
   [Pannangpetch, Patchareewan; Kukongviriyapan, Veerapol] Khon Kaen Univ, Fac Med, Dept Pharmacol, Khon Kaen 40002, Thailand.
   [Prachaney, Parichat] Khon Kaen Univ, Fac Med, Dept Anat, Khon Kaen 40002, Thailand.
   [Greenwald, Stephen E.] Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London E1 2ES, England.
C3 Khon Kaen University; Khon Kaen University; Khon Kaen University;
   University of London; Queen Mary University London
RP Kukongviriyapan, U (corresponding author), Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
EM ketmanee.879@gmail.com; upa_ku@kku.ac.th; weerapons@kkumail.com;
   ppoung@kku.ac.th; patc_pan@kku.ac.th; parpra@kku.ac.th;
   s.e.greenwald@qmul.ac.uk; veerapol@kku.ac.th
RI Greenwald, Stephen/C-6928-2012
OI Sangartit, Weerapon/0000-0002-5058-2294; Greenwald,
   Stephen/0000-0002-8471-7070
FU Agricultural Research Development Agency Fund; Thailand Research Fund;
   Khon Kaen University Research Fund; Invitation Research Fund, Faculty of
   Medicine, Khon Kaen University; Royal Golden Jubilee PhD Program, the
   Thailand Research Fund [PHD/0048/2553]
FX This work was supported by grants from the Agricultural Research
   Development Agency Fund, the Thailand Research Fund, the Khon Kaen
   University Research Fund and the Invitation Research Fund, Faculty of
   Medicine, Khon Kaen University. Senaphan K. was supported by a
   scholarship (PHD/0048/2553) from the Royal Golden Jubilee PhD Program,
   the Thailand Research Fund.
CR Alam MA, 2013, J CARDIOVASC PHARM, V61, P240, DOI 10.1097/FJC.0b013e31827cb600
   Alam MA, 2013, NUTRIENTS, V5, P637, DOI 10.3390/nu5030637
   ALLAIN CC, 1974, CLIN CHEM, V20, P470
   Ardiansyah, 2008, J AGR FOOD CHEM, V56, P2825, DOI 10.1021/jf072896y
   Aydin S, 2014, NUTRITION, V30, P1, DOI 10.1016/j.nut.2013.05.013
   Balasubashini MS, 2003, ACTA DIABETOL, V40, P118, DOI 10.1007/s00592-003-0099-6
   Bonadonna RC, 2006, DIABETES CARE, V29, P2701, DOI 10.2337/dc06-0942
   Boonla O, 2014, NITRIC OXIDE-BIOL CH, V42, P44, DOI 10.1016/j.niox.2014.09.001
   Boonloh K, 2015, FOOD FUNCT, V6, P566, DOI [10.1039/c4fo00872c, 10.1039/C4FO00872C]
   Bourne L, 2000, FREE RADICAL RES, V32, P273, DOI 10.1080/10715760000300281
   Cai H, 2000, CIRC RES, V87, P840, DOI 10.1161/01.RES.87.10.840
   Chatzizisis YS, 2007, J AM COLL CARDIOL, V49, P2379, DOI 10.1016/j.jacc.2007.02.059
   Cooper-DeHoff RM, 2010, JAMA-J AM MED ASSOC, V304, P61, DOI 10.1001/jama.2010.884
   Gupta N, 2012, ENDOCR REV, V33, P48, DOI 10.1210/er.2010-0028
   Jung EH, 2007, J AGR FOOD CHEM, V55, P9800, DOI 10.1021/jf0714463
   Kennedy AJ, 2010, DIS MODEL MECH, V3, P156, DOI 10.1242/dmm.003467
   Luangaram S, 2007, FOOD CHEM TOXICOL, V45, P448, DOI 10.1016/j.fct.2006.09.008
   Manach C, 2004, AM J CLIN NUTR, V79, P727, DOI 10.1093/ajcn/79.5.727
   Mancuso C, 2014, FOOD CHEM TOXICOL, V65, P185, DOI 10.1016/j.fct.2013.12.024
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Nakmareong S, 2012, HYPERTENS RES, V35, P418, DOI 10.1038/hr.2011.180
   Nakmareong S, 2011, N-S ARCH PHARMACOL, V383, P519, DOI 10.1007/s00210-011-0624-z
   Nascimento AR, 2013, OBESITY, V21, P2046, DOI 10.1002/oby.20358
   Otani H, 2011, ANTIOXID REDOX SIGN, V15, P1911, DOI 10.1089/ars.2010.3739
   Ou L, 2003, BIOL PHARM BULL, V26, P1511, DOI 10.1248/bpb.26.1511
   Panchal SK, 2011, J CARDIOVASC PHARM, V57, P51, DOI [10.1097/FJC.0b013e3181feb90a, 10.1097/FJC.0b013e31821b1379]
   Panchal SK, 2011, J BIOMED BIOTECHNOL, DOI 10.1155/2011/351982
   Prakash D, 2011, Journal of Complementary and Integrative Medicine, V8, DOI [10.2202/1553-3840.1513, DOI 10.2202/1553-3840.1513]
   Roberts CK, 2005, J APPL PHYSIOL, V98, P203, DOI 10.1152/japplphysiol.00463.2004
   Rodrigo R, 2011, HYPERTENS RES, V34, P431, DOI 10.1038/hr.2010.264
   Rotter V, 2003, J BIOL CHEM, V278, P45777, DOI 10.1074/jbc.M301977200
   Son MJ, 2010, J CLIN BIOCHEM NUTR, V46, P150, DOI 10.3164/jcbn.09-98
   Suzuki A, 2007, AM J HYPERTENS, V20, P508, DOI 10.1016/j.amjhyper.2006.11.008
   Tsao R, 2010, NUTRIENTS, V2, P1231, DOI 10.3390/nu2121231
   Wang BH, 2004, J CARDIOVASC PHARM, V43, P549, DOI 10.1097/00005344-200404000-00010
   Williamson G, 2005, AM J CLIN NUTR, V81, p243S, DOI 10.1093/ajcn/81.1.243S
   Zhao ZH, 2008, FOOD CHEM, V109, P691, DOI 10.1016/j.foodchem.2008.02.039
NR 37
TC 80
Z9 84
U1 1
U2 42
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2015
VL 7
IS 8
BP 6446
EP 6464
DI 10.3390/nu7085283
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CQ4PQ
UT WOS:000360587500024
PM 26247970
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Paliwal, S
   Jain, S
   Mudgal, P
   Verma, K
   Paliwal, S
   Sharma, S
AF Paliwal, Swati
   Jain, Smita
   Mudgal, Pallavi
   Verma, Kanika
   Paliwal, Sarvesh
   Sharma, Swapnil
TI Mitochondrial transfer restores impaired liver functions by
   AMPK/mTOR/PI3K-AKT pathways in metabolic syndrome
SO LIFE SCIENCES
LA English
DT Article
DE Metabolic syndrome; Mitochondria transplantation; Metabolic
   reprogramming; Fatty-acid beta oxidation; Mitochondrial bioenergetics
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; SKELETAL-MUSCLE; TRANSPLANTATION;
   DYSFUNCTION; HEART; PROTECTS; MICE
AB Aim: We investigated the effect of mitochondria transfer in high fat diet and streptozotocin (HFD + STZ) induced metabolic syndrome (MeS) in rats. The effect of mitochondria transfer in MeS with co-existing hypertension, hyperlipidaemia, diabetes and fatty liver together, has not been reported.Materials and methods: Heathy mitochondria was transferred intravenously and the effect on several physiological parameters and biochemical parameters were examined in HFD + STZ rats. In addition, RNA-sequencing of healthy liver tissues was performed to elucidate the molecular pathways affected by mitochondria transfer in restoring metabolic health.Key findings: We observed reduction in both systolic and diastolic blood pressure levels, reduced blood glucose levels, and a marked reduction in serum lipid profiles. The levels of alanine transaminase (ALT) and aspartate transaminase (AST) also improved along with evident restoration of liver morphology demonstrated by histopathological analysis. Enhanced mitochondrial biogenetics and reduction in oxidative stress and inflammatory markers was also observed. The pathway enrichment analysis revealed reduction in insulin resistance, inflammatory markers, regulation of mitochondrial bioenergetics, calcium ion homeostasis, fatty-acid beta-oxidation, cytokine immune regulators, and enhanced lipid solubilisation. The significant effect of healthy mitochondria transfer in restoration of metabolic functions was observed by the activation of PI3K-AKT, AMPK/mTOR pathways and cytokine immune regulators, suggesting that inflammatory mediators were also significantly affected after mitochondria transfer.Significance: This study, provides insights on molecular processes triggered by mitochondria transfer in fatty liver regeneration and improvement of overall metabolic health.
C1 [Paliwal, Swati; Mudgal, Pallavi] Banasthali Vidyapith, Dept Biosci & Biotechnol, Banasthali 304022, Rajasthan, India.
   [Jain, Smita; Verma, Kanika; Paliwal, Sarvesh; Sharma, Swapnil] Banasthali Vidyapith, Dept Pharm, Banasthali 304022, Rajasthan, India.
C3 Banasthali Vidyapith; Banasthali Vidyapith
RP Paliwal, S (corresponding author), Banasthali Vidyapith, Dept Biosci & Biotechnol, Banasthali 304022, Rajasthan, India.
EM swatipaliwal@banasthali.in
RI Verma, Kanika/GZA-3489-2022; Paliwal, Sarvesh/GQQ-1555-2022; Paliwal,
   Swati/HGA-7665-2022; Jain, Smita/KLB-9548-2024; Sharma,
   Swapnil/AAV-4850-2020
OI Paliwal, Swati/0000-0001-8498-6310
CR Almeda-Valdés P, 2009, ANN HEPATOL, V8, pS18, DOI 10.1016/S1665-2681(19)31822-8
   Ameen O, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-20945-7
   Aon MA, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00094
   Barrientos Antoni, 2009, Curr Protoc Hum Genet, VChapter 19, DOI 10.1002/0471142905.hg1903s63
   Belosludtsev KN, 2021, MITOCHONDRION, V59, P246, DOI 10.1016/j.mito.2021.06.008
   Bi YK, 2021, STEM CELL RES THER, V12, DOI 10.1186/s13287-021-02663-5
   Cho K, 2015, SCI REP-UK, V5, DOI 10.1038/srep08145
   Cowan DB, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0160889
   De Magalhaes DA, 2019, AN ACAD BRAS CIENC, V91, DOI 10.1590/0001-3765201920180314
   Di Meo S, 2017, J ENDOCRINOL, V233, pR15, DOI 10.1530/JOE-16-0598
   Doulamis IP, 2020, AM J PHYSIOL-RENAL, V319, pF403, DOI 10.1152/ajprenal.00255.2020
   Elkind MSV, 2009, CEREBROVASC DIS, V28, P266, DOI 10.1159/000228709
   Emani SM, 2018, TRANSL PEDIATR, V7, P169, DOI 10.21037/tp.2018.02.02
   Ferreira-Santos P, 2020, J FUNCT FOODS, V73, DOI 10.1016/j.jff.2020.104098
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   Fu AL, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00241
   Garcia D, 2017, MOL CELL, V66, P789, DOI 10.1016/j.molcel.2017.05.032
   Gastaldi G, 2008, Rev Med Suisse, V4, P1387
   Guariento A, 2020, J HEART LUNG TRANSPL, V39, P1279, DOI 10.1016/j.healun.2020.06.023
   Halpern A, 2010, DIABETOL METAB SYNDR, V2, DOI 10.1186/1758-5996-2-55
   Hayashida K, 2021, J TRANSL MED, V19, DOI 10.1186/s12967-021-02878-3
   Haythorne E, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-10189-x
   Kaza AK, 2017, J THORAC CARDIOV SUR, V153, P934, DOI 10.1016/j.jtcvs.2016.10.077
   Kim JA, 2008, CIRC RES, V102, P401, DOI 10.1161/CIRCRESAHA.107.165472
   Konari N, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-40163-y
   Kubat GB, 2021, J BIOCHEM MOL TOXIC, V35, DOI 10.1002/jbt.22612
   Lasker S, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-56538-0
   Lin MT, 2006, NATURE, V443, P787, DOI 10.1038/nature05292
   Masuzawa A, 2013, AM J PHYSIOL-HEART C, V304, pH966, DOI 10.1152/ajpheart.00883.2012
   Mitchell T, 2012, FREE RADICAL BIO MED, V52, P838, DOI 10.1016/j.freeradbiomed.2011.12.014
   Ohta Y, 2011, AM J PHYSIOL-HEART C, V300, pH1637, DOI 10.1152/ajpheart.01185.2009
   Paliwal S, 2018, STEM CELL RES THER, V9, DOI 10.1186/s13287-018-1012-0
   Pourmohammadi-Bejarpasi Z, 2020, BRAIN RES BULL, V165, P70, DOI 10.1016/j.brainresbull.2020.09.018
   Pozzo L, 2016, LIFE SCI, V166, P149, DOI 10.1016/j.lfs.2016.09.022
   Sergi D, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00532
   Shen KN, 2022, ANNU REV CELL DEV BI, V38, P179, DOI 10.1146/annurev-cellbio-120420-015303
   Spinazzi M, 2012, NAT PROTOC, V7, P1235, DOI 10.1038/nprot.2012.058
   Stoolman JS, 2022, FRONT CELL DEV BIOL, V10, DOI 10.3389/fcell.2022.981464
   Takahara M, 2014, REV ENDOCR METAB DIS, V15, P317, DOI 10.1007/s11154-014-9294-8
   Zhao ZZ, 2021, BIOENG TRANSL MED, V6, DOI 10.1002/btm2.10209
NR 40
TC 9
Z9 9
U1 3
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD NOV 1
PY 2023
VL 332
AR 122116
DI 10.1016/j.lfs.2023.122116
EA SEP 2023
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA X5XQ3
UT WOS:001099184000001
PM 37739165
DA 2025-06-11
ER

PT J
AU Choi, SH
   Choi-Kwon, S
AF Choi, Seung-Hye
   Choi-Kwon, Smi
TI The effects of the DASH diet education program with omega-3 fatty acid
   supplementation on metabolic syndrome parameters in elderly women with
   abdominal obesity
SO NUTRITION RESEARCH AND PRACTICE
LA English
DT Article
DE Self efficacy; nutrition; metabolic syndrome; women
ID POLYUNSATURATED FATTY-ACIDS; CARDIOVASCULAR RISK-FACTORS;
   BLOOD-PRESSURE; SELF-EFFICACY; HYPERTENSION; DISEASE; ASSOCIATION;
   ADIPONECTIN; SENSITIVITY; NUTRITION
AB BACKGROUND/OBJECTIVES: The purpose of this study was to investigate the overall effects of a tailored Dietary Approaches to Stop Hypertension (DASH) nutritional intervention program which included omega-3 fatty acids supplementation, on dietary self-efficacy, dietary knowledge, and dietary behaviors in Korean elderly women with abdominal obesity. Furthermore, we investigated the effects of the program on metabolic syndrome parameters including the antioxidant capacities in these subjects.
   SUBJECTS/METHODS: A randomized, controlled trial was conducted for 8 weeks. The experimental group (n = 21) received a weekly tailored nutritional program for 8 weeks and the control group (n = 18) received only one educational session. The clinical survey was conducted before and after the intervention period.
   RESULTS: After the intervention, dietary self-efficacy (P = 0.023), frequency of fruit intake (P = 0.019), and dietary fiber intake (P = 0.044) were higher in the experimental group than in the control group. The oxidative stress (P < 0.001) was lower in the experimental group than in the control group. Moreover, low density lipoprotein (LDL) cholesterol (P = 0.023) had significantly decreased in the experimental group but not in the control group after the intervention.
   CONCLUSIONS: The intervention program including omega-3 fatty acid supplementation had a positive effect on dietary self-efficacy, dietary behaviors, and oxidative stress among aged women with abdominal obesity.
C1 [Choi, Seung-Hye] Suwon Univ, Dept Nursing Sci, Gyeonggi 445743, South Korea.
   [Choi-Kwon, Smi] Seoul Natl Univ, Coll Nursing, 103 Daehak Ro, Seoul 110799, South Korea.
   [Choi-Kwon, Smi] Seoul Natl Univ, Res Inst Nursing Sci, Seoul 110799, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU)
RP Choi-Kwon, S (corresponding author), Seoul Natl Univ, Coll Nursing, 103 Daehak Ro, Seoul 110799, South Korea.
EM smi@snu.ac.kr
RI Choi, Jah/AAA-4835-2022; Choi, Su-Yeon/C-4312-2013
CR [Anonymous], 2010, DIETARY REFERENCE IN, V1st
   Azadbakht L, 2005, DIABETES CARE, V28, P2823, DOI 10.2337/diacare.28.12.2823
   BANDURA A, 1977, PSYCHOL REV, V84, P191, DOI 10.1037/0033-295X.84.2.191
   Benzie IFF, 1996, ANAL BIOCHEM, V239, P70, DOI 10.1006/abio.1996.0292
   Davis L, 2007, EUR J NUTR, V46, P155, DOI 10.1007/s00394-007-0647-x
   Fisman EZ, 2014, CARDIOVASC DIABETOL, V13, DOI 10.1186/1475-2840-13-103
   García-Alonso FJ, 2012, EUR J NUTR, V51, P415, DOI 10.1007/s00394-011-0225-0
   Glanz K., 2008, HLTH BEHAV HLTH ED T, V4
   Guigoz Y, 1996, NUTR REV, V54, pS59
   Gyeongin Regional Statistics Office, 2012, CONS PRIC TRENDS
   Hyun DH, 2006, P NATL ACAD SCI USA, V103, P19908, DOI 10.1073/pnas.0608008103
   Ignarro LJ, 2007, CARDIOVASC RES, V73, P326, DOI 10.1016/j.cardiores.2006.06.030
   Jeong KH, 2011, HLTH WELF POLICY FOR, P16
   Jeong SK, 2004, BMC PUBLIC HEALTH, V4, DOI 10.1186/1471-2458-4-31
   Ju K, 2008, J KOREAN ACAD NURS, V38, P64, DOI 10.4040/jkan.2008.38.1.64
   Kabir M, 2007, AM J CLIN NUTR, V86, P1670
   Kim BokHee Kim BokHee, 2005, Korean Journal of Community Nutrition, V10, P952
   Kim Jeong-Ran, 2010, THESIS
   Kim So Hyun, 2012, Journal of korean biological nursing science, V14, P16
   Kwon S, 2009, HEALTH CARE WOMEN IN, V30, P447, DOI 10.1080/07399330802662093
   권혁상, 2005, [The Korean Journal of Medicine, 대한내과학회지], V68, P359
   Lee Seung Eun, 2007, Journal of Obesity & Metabolic Syndrome, V16, P147
   Mantzoros CS, 2006, AM J CLIN NUTR, V84, P328
   MILLER DM, 1989, ARCH BIOCHEM BIOPHYS, V271, P113, DOI 10.1016/0003-9861(89)90261-0
   Ministry of Health and Welfare; Korea Centers for Disease Control and Prevention. Korea Health Statistics, 2008, KOR HLTH STAT 2008 K
   Mumford SL, 2011, AM J EPIDEMIOL, V173, P145, DOI 10.1093/aje/kwq388
   Obarzanek E, 2001, AM J CLIN NUTR, V74, P80
   Oh C, 2014, NUTR RES PRACT, V8, P192, DOI [10.4162/nrp.2014.8.1.192, 10.4162/nrp.2014.8.2.192]
   Panagiotakos DB, 2007, J AM DIET ASSOC, V107, P979, DOI 10.1016/j.jada.2007.03.006
   허주미, 2011, [Journal of Menopausal Medicine, 대한폐경학회지], V17, P12
   Poudyal H, 2011, PROG LIPID RES, V50, P372, DOI 10.1016/j.plipres.2011.06.003
   Puglisi MJ, 2011, J NUTR BIOCHEM, V22, P101, DOI 10.1016/j.jnutbio.2010.07.003
   Sacks FM, 2001, NEW ENGL J MED, V344, P3, DOI 10.1056/NEJM200101043440101
   Shenoy SF, 2010, NUTR J, V9, DOI 10.1186/1475-2891-9-8
   Shi ZM, 2011, NUTRITION, V27, P194, DOI 10.1016/j.nut.2010.01.012
   Shin, 2008, THESIS, DOI 3342291
   The Korean Nutrition Society, 2007, COMP AID NUTR AN PRO
   ZEMEL MB, 1988, AM J CARDIOL, V61, pH7, DOI 10.1016/0002-9149(88)91098-3
NR 38
TC 12
Z9 13
U1 0
U2 15
PU KOREAN NUTRITION SOC
PI SEOUL
PA 804 KST CTR, 635-4 YEOGSAM-SONG KANGNAM-KU, SEOUL, 135-703, SOUTH KOREA
SN 1976-1457
EI 2005-6168
J9 NUTR RES PRACT
JI Nutr. Res. Pract.
PD APR
PY 2015
VL 9
IS 2
BP 150
EP 157
DI 10.4162/nrp.2015.9.2.150
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CF6NC
UT WOS:000352672400007
PM 25861421
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Li, BB
   Pang, K
   Hao, L
   Zang, GH
   Wang, J
   Wang, XT
   Zhang, JJ
   Cai, LJ
   Yang, CD
   Han, CH
AF Li, Bi-Bo
   Pang, Kun
   Hao, Lin
   Zang, Guang-Hui
   Wang, Jian
   Wang, Xi-Tao
   Zhang, Jian-Jun
   Cai, Long-Jun
   Yang, Chen-Di
   Han, Cong-Hui
TI Corosolic acid improves erectile function in metabolic syndrome rats by
   reducing reactive oxygen species generation and increasing nitric oxide
   bioavailability
SO FOOD SCIENCE AND TECHNOLOGY
LA English
DT Article
DE corosolic acid; MED; ROS; bioavailability
ID OXIDATIVE STRESS; NADPH OXIDASES; HYPERTENSION
AB To investigate the effect of corosolic acid treatment on erectile function in metabolic syndrome induced rat model. Fifty male 3-week-old SD rats were fed a high fat and high sugar diet. Six months later, metabolic variables were determined. Metabolic syndrome induced erectile function (MED) rats were confirmed by an apomorphine test. Then MED rats were treated with corosolic acid daily by oral gavage for 4 weeks. To evaluate erectile function, intracavernosal pressure (ICP)/mean arterial blood pressure (MAP) ratio was measured. Thiobarbituric acid reactive substances assay and dihydroethidium staining were used to assess reactive oxygen species (ROS) level. Protein expressions of gp91(Phox) and eNOS were examined by western blotting and immunohistochemistry. Fasting blood glucose, body weight, total cholesterol and insulin were markedly increased in metabolic syndrome rats compared with those of the control rats (p < 0.05). The ratios of max ICP/MAP and area under curve (AUC)/MAP was markedly reduced in MED rats compared with the control rats (p < 0.05). The concentration of cyclic guanosine mono-phosphate (cGMP) and the expression of eNOS were significantly decreased in MED rats compared with the control group (p < 0.05). Moreover, ROS level and the expression of gp91(Phox) were significantly increased in MED rats. Treatment with corosolic acid reversed these changes (each p < 0.05). Corosolic acid reduces the level of ROS, ameliorating endothelial dysfunction and improvement of erectile function in MED rats.
C1 [Li, Bi-Bo] Nanjing Univ Chinese Med, Taizhou Affiliated Hosp, Dept Urol, Taizhou, Jiangsu, Peoples R China.
   [Pang, Kun; Hao, Lin; Zang, Guang-Hui; Wang, Jian; Wang, Xi-Tao] Xuzhou Cent Hosp, Dept Urol, Xuzhou, Jiangsu, Peoples R China.
   [Zhang, Jian-Jun; Cai, Long-Jun] Nanjing Drum Tower Hosp Grp, Suqian Peoples Hosp, Dept Urol, Suqian, Jiangsu, Peoples R China.
   [Yang, Chen-Di] Suzhou Hosp Chinese Med, Dept Urol, Suzhou, Jiangsu, Peoples R China.
   [Han, Cong-Hui] Nanjing Univ Chinese Med, Xuzhou Cent Hosp, Dept Urol, Xuzhou, Jiangsu, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine
RP Han, CH (corresponding author), Nanjing Univ Chinese Med, Xuzhou Cent Hosp, Dept Urol, Xuzhou, Jiangsu, Peoples R China.
EM hanch509@hotmail.com
RI YANG, Chendi/LXV-8671-2024
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Bedard K, 2007, PHYSIOL REV, V87, P245, DOI 10.1152/physrev.00044.2005
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Drummond GR, 2011, NAT REV DRUG DISCOV, V10, P453, DOI 10.1038/nrd3403
   Fukushima M, 2006, DIABETES RES CLIN PR, V73, P174, DOI 10.1016/j.diabres.2006.01.010
   Gonzaga NA, 2020, NITRIC OXIDE-BIOL CH, V94, P19, DOI 10.1016/j.niox.2019.10.006
   Guo XL, 2016, EUR J PHARMACOL, V791, P578, DOI 10.1016/j.ejphar.2016.09.031
   Horlad H, 2013, MOL NUTR FOOD RES, V57, P1046, DOI 10.1002/mnfr.201200610
   Li R, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-12907-1
   Li XQ, 2016, SCI REP-UK, V6, DOI 10.1038/srep26854
   Li Y, 2016, ANTIOXID REDOX SIGN, V24, P893, DOI 10.1089/ars.2015.6479
   Long H, 2016, J SEX MED, V13, P1056, DOI 10.1016/j.jsxm.2016.04.073
   Peng MZ, 2019, NITRIC OXIDE-BIOL CH, V82, P12, DOI 10.1016/j.niox.2018.11.002
   Shabsigh R, 2016, SEX MED-UK, V4, pE135, DOI 10.1016/j.esxm.2016.03.027
   Vrankova S, 2019, J PHYSIOL PHARMACOL, V70, P535, DOI 10.26402/jpp.2019.4.05
   Woo SM, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19051309
   Xiao B, 2010, J PHARMACOL EXP THER, V334, P784, DOI 10.1124/jpet.110.167510
   Yamada K, 2008, BIOL PHARM BULL, V31, P651, DOI 10.1248/bpb.31.651
   Yamaguchi Y, 2006, LIFE SCI, V79, P2474, DOI 10.1016/j.lfs.2006.08.007
NR 19
TC 0
Z9 0
U1 2
U2 7
PU SOC BRASILEIRA CIENCIA TECNOLOGIA ALIMENTOS
PI CAMPINAS
PA AV BRASIL 2880, CAXIA POSTAL 271 CEP 13001-970, CAMPINAS, SAO PAULO
   00000, BRAZIL
SN 0101-2061
EI 1678-457X
J9 FOOD SCI TECH-BRAZIL
JI Food Sci. Technol.
PY 2022
VL 42
AR e108821
DI 10.1590/fst.108821
PG 5
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 0D5RY
UT WOS:000776053700003
OA gold
DA 2025-06-11
ER

PT J
AU Oyovwi, MO
   Ugwuishi, EW
   Udi, OA
   Uchechukwu, GJ
AF Oyovwi, Mega Obukohwo
   Ugwuishi, Emeka Williams
   Udi, Onoriode Andrew
   Uchechukwu, Gregory Joseph
TI Mitophagy Unveiled: Exploring the Nexus of Mitochondrial Health and
   Neuroendocrinopathy
SO JOURNAL OF MOLECULAR NEUROSCIENCE
LA English
DT Article
DE Mitophagy; Mitochondrial health; Neuroendocrinopathy; Oxidative stress;
   Therapeutic interventions; Cellular resilience; Mitochondrial dynamics
ID AMYLOID-BETA TOXICITY; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE;
   NEURODEGENERATIVE DISEASES; OXIDATIVE STRESS; SKELETAL-MUSCLE;
   DYSFUNCTION; MECHANISMS; PROTEIN; SIRT1
AB Mitochondria play a pivotal role in cellular metabolism, energy production, and apoptotic signaling, making mitophagy, the selective degradation of damaged mitochondria, crucial for mitochondrial health. Dysregulation of mitophagy has been implicated in various neuroendocrinopathies, yet the mechanisms linking these processes remain poorly understood. This review aims to explore the intersection between mitophagy and neuroendocrinopathy, addressing the critical gaps in knowledge regarding how mitochondrial dysfunction may contribute to the pathophysiology of neuroendocrine disorders. We conducted a comprehensive literature review of studies published on mitophagy and neuroendocrinopathies, focusing on data that elucidate the pathways involved and the clinical implications of mitochondrial health in neuroendocrine contexts. Our findings indicate that altered mitophagy may lead to the accumulation of dysfunctional mitochondria, contributing to neuroendocrine dysregulation. We present evidence linking impaired mitochondrial clearance to disease models of conditions such as metabolic syndrome, depression, and stress-related disorders, highlighting the potential for therapeutic interventions targeting mitophagy. While significant advances have been made in understanding mitochondrial biology, the direct interplay between mitophagy and neuroendocrinopathies remains underexplored. This review underscores the necessity for further research to elucidate these connections, which may offer novel insights into disease mechanisms and therapeutic strategies for treating maladaptive neuroendocrine responses.
C1 [Oyovwi, Mega Obukohwo] Adeleke Univ, Fac Basic Med Sci, Dept Physiol, Ede, Osun, Nigeria.
   [Ugwuishi, Emeka Williams] Univ Nigeria, Coll Med, Dept Physiol, Enugu, Nigeria.
   [Udi, Onoriode Andrew] Fed Univ Otuoke, Dept Human Anat, Otuoke, Bayelsa, Nigeria.
   [Uchechukwu, Gregory Joseph] Adeleke Univ, Fac Basic Med Sci, Dept Med Lab Sci, Ede, Osun, Nigeria.
C3 University of Nigeria
RP Oyovwi, MO (corresponding author), Adeleke Univ, Fac Basic Med Sci, Dept Physiol, Ede, Osun, Nigeria.
EM megalect@gmail.com
RI Obukohwo, Oyovwi/GRO-1623-2022
CR Agarwal S, 2022, CURR OPIN NEUROBIOL, V72, P111, DOI 10.1016/j.conb.2021.09.005
   Agorastos A, 2016, J PINEAL RES, V61, P3, DOI 10.1111/jpi.12330
   Ajayi AF, 2024, MOL BIOL REP, V51, DOI 10.1007/s11033-024-09823-9
   Al-Gadi IS, 2018, J ENDOCR SOC, V2, P361, DOI 10.1210/js.2017-00434
   Al-Suhaimi E, 2024, ENDOCRINE, V86, P903, DOI 10.1007/s12020-024-03967-1
   Alqahtani T, 2023, MITOCHONDRION, V71, P83, DOI 10.1016/j.mito.2023.05.007
   Aman Y, 2020, INT REV NEUROBIOL, V155, P169, DOI 10.1016/bs.irn.2020.02.008
   Antoniel M, 2014, INT J MOL SCI, V15, P7513, DOI 10.3390/ijms15057513
   Anwar T, 2019, Autophagosome biogenesis: ATG4, TRIM17 and Beclin 1 localization
   Ariyanto EF., 2024, Herb Med Prod Metab Dis-New Integr Pharmacol Approaches, DOI [10.3389/fphar.2024.1366551, DOI 10.3389/FPHAR.2024.1366551]
   Azam S, 2022, MOLECULES, V27, DOI 10.3390/molecules27092827
   Baker MJ, 2022, OPEN BIOL, V12, DOI 10.1098/rsob.220274
   Bauer NC, 2014, Doctoral dissertation
   Ben-Azu B, 2023, FRONT CELL NEUROSCI, V17, DOI 10.3389/fncel.2023.1139357
   Ben-Azu B, 2022, METAB BRAIN DIS, V37, P2807, DOI 10.1007/s11011-022-01075-5
   Berlanga-Acosta JA, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.573032
   Bhasin H, 2023, PHYSIOL BEHAV, V261, DOI 10.1016/j.physbeh.2022.114072
   Bhatia Vandana, 2021, J Neurol Sci, V421, P117253, DOI 10.1016/j.jns.2020.117253
   Campbell JE, 2021, NAT REV MOL CELL BIO, V22, P142, DOI 10.1038/s41580-020-00317-7
   Chakrabarty Ram Prosad, 2022, Biochem (Lond), V44, P2, DOI 10.1042/bio_2022_119
   Chakravorty A, 2019, FRONT AGING NEUROSCI, V11, DOI 10.3389/fnagi.2019.00311
   Chen XH, 2020, AGING-US, V12, P24504, DOI 10.18632/aging.202453
   Chen XN, 2024, EUR J PHARMACOL, V975, DOI 10.1016/j.ejphar.2024.176647
   Chen YQ, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/4629189
   Cheng CF, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19113447
   Cioffi F, 2022, GENES-BASEL, V13, DOI 10.3390/genes13020315
   Ciubuc-Batcu MT, 2024, BBA-MOL BASIS DIS, V1870, DOI 10.1016/j.bbadis.2023.166920
   Connelly EM, 2023, CELL SIGNAL, V106, DOI 10.1016/j.cellsig.2023.110631
   Davinelli S, 2020, TRENDS ENDOCRIN MET, V31, P536, DOI 10.1016/j.tem.2020.02.011
   Dietrich MO, 2008, J NEUROSCI, V28, P10766, DOI 10.1523/JNEUROSCI.2744-08.2008
   Dikic I, 2018, NAT REV MOL CELL BIO, V19, P349, DOI 10.1038/s41580-018-0003-4
   Doblado L, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22083903
   Dong YZ, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11050893
   Dudley LJ, 2020, FEBS J, V287, P4806, DOI 10.1111/febs.15334
   East DA, 2014, CHEM BIOL, V21, P1585, DOI 10.1016/j.chembiol.2014.09.019
   Fan P, 2019, DNA CELL BIOL, V38, P10, DOI 10.1089/dna.2018.4348
   Fang EF, 2019, NAT NEUROSCI, V22, P401, DOI 10.1038/s41593-018-0332-9
   Fernandez-Marcos PJ, 2011, AM J CLIN NUTR, V93, p884S, DOI 10.3945/ajcn.110.001917
   Fontana L, 2015, CELL, V161, P106, DOI 10.1016/j.cell.2015.02.020
   García-Villalba R, 2022, MOL NUTR FOOD RES, V66, DOI 10.1002/mnfr.202101019
   Ge P, 2020, MOL NEURODEGENER, V15, DOI 10.1186/s13024-020-00367-7
   Gegg ME, 2010, HUM MOL GENET, V19, P4861, DOI 10.1093/hmg/ddq419
   Georgakopoulos ND, 2017, NAT CHEM BIOL, V13, P136, DOI [10.1038/NCHEMBIO.2287, 10.1038/nchembio.2287]
   Ghosh A, 2010, FREE RADICAL BIO MED, V49, P1674, DOI 10.1016/j.freeradbiomed.2010.08.028
   Gibb A. A., 2022, Exercise metabolism, P263
   Giorgi C, 2018, NAT REV MOL CELL BIO, V19, P713, DOI 10.1038/s41580-018-0052-8
   Glatigny M, 2019, CURR BIOL, V29, P435, DOI 10.1016/j.cub.2018.12.021
   Grancara S, 2016, AMINO ACIDS, V48, P2327, DOI 10.1007/s00726-016-2264-6
   Grilo LF, 2021, EUR J CLIN INVEST, V51, DOI 10.1111/eci.13625
   Grumati P, 2018, J BIOL CHEM, V293, P5404, DOI 10.1074/jbc.TM117.000117
   Gualtieri R, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10030337
   Gubbi S., 2023, Environmental Endocrinology and Endocrine Disruptors, P1
   Guo YQ, 2023, CHEM-BIOL INTERACT, V384, DOI 10.1016/j.cbi.2023.110723
   Gurd BJ, 2011, APPL PHYSIOL NUTR ME, V36, P589, DOI [10.1139/H11-070, 10.1139/h11-070]
   Gustafsson ÅB, 2019, PHYSIOL REV, V99, P853, DOI 10.1152/physrev.00005.2018
   Haberman RP, 2017, NEUROTHERAPEUTICS, V14, P662, DOI 10.1007/s13311-017-0541-z
   Harrison NA, 2009, Lishman's Organic Psychiatry: A textbook of Neuropsychiatry, V4th, P617, DOI [10.1002/9781444316803.ch10, DOI 10.1002/9781444316803.CH10]
   He WY, 2020, SKELET MUSCLE, V10, DOI 10.1186/s13395-020-00245-2
   Hosoda R, 2023, J PHARMACOL SCI, V152, P112, DOI [10.1016/jahs.2023.04.001, 10.1016/j.jphs.2023.04.001]
   Hroudová J, 2013, NEURAL REGEN RES, V8, P363, DOI 10.3969/j.issn.1673-5374.2013.04.009
   Hu D, 2021, FRONT NEUROSCI-SWITZ, V15, DOI 10.3389/fnins.2021.746873
   Hu HT, 2016, BIOCHEM BIOPH RES CO, V478, P174, DOI 10.1016/j.bbrc.2016.07.071
   Huang CP, 2020, NUTRIENTS, V12, DOI 10.3390/nu12071950
   Huang MH, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms231810808
   Huang Y, 2021, FRONT CELL DEV BIOL, V9, DOI 10.3389/fcell.2021.679637
   Huynh DP, 2003, HUM MOL GENET, V12, P2587, DOI 10.1093/hmg/ddg269
   Hwang K, 2019, EXP NEUROBIOL, V28, P679, DOI 10.5607/en.2019.28.6.679
   Islam H, 2020, APPL PHYSIOL NUTR ME, V45, P11, DOI 10.1139/apnm-2019-0069
   Jain R, 2024, MITOCHONDRION, V74, DOI 10.1016/j.mito.2023.11.007
   Jain R, 2023, BIOMED PHARMACOTHER, V159, DOI 10.1016/j.biopha.2023.114268
   Jamwal S, 2021, PHARMACOL THERAPEUT, V219, DOI 10.1016/j.pharmthera.2020.107705
   Jang SY, 2012, J BIOL CHEM, V287, P19304, DOI 10.1074/jbc.M112.363747
   Jha SK, 2017, BBA-MOL BASIS DIS, V1863, P1132, DOI 10.1016/j.bbadis.2016.06.015
   Jiang M, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.789267
   Jiang Q, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/8837893
   Joshi V, 2020, MED RES REV, V40, P1385, DOI 10.1002/med.21662
   Juhaszova M, 2022, FUNCTION, V3, DOI 10.1093/function/zqab065
   Junghans M, 2022, FRONT CELL NEUROSCI, V16, DOI 10.3389/fncel.2022.963169
   Jurcau MC, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11112167
   Kalyanaraman B, 2020, REDOX BIOL, V36, DOI 10.1016/j.redox.2020.101665
   Kaneko H, 2018, AMINO ACIDS, V50, P527, DOI 10.1007/s00726-018-2550-6
   Kaplan P, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21207698
   Khan T, 2022, PHARMACEUTICS, V14, DOI 10.3390/pharmaceutics14122657
   Kidd P M, 2000, Altern Med Rev, V5, P502
   Kim J, 2016, MOL NEURODEGENER, V11, DOI 10.1186/s13024-016-0121-4
   Kim Y, 2019, ANTIOXID REDOX SIGN, V31, P275, DOI 10.1089/ars.2018.7606
   Koliaki C, 2016, ANNU REV NUTR, V36, P337, DOI 10.1146/annurev-nutr-071715-050656
   Kumaraguru S., 2021, Arch Neurol Neurol Disord, V4, P123
   Kuno A, 2022, CARDIOVASC RES, V118, P3360, DOI 10.1093/cvr/cvac026
   Lednovich KR., 2022, Gpcrs as Therapeutic Targets, V2, P521, DOI [10.1002/9781119564782.ch15, DOI 10.1002/9781119564782.CH15]
   Lehmann M, 2015, NEUROBIOL AGING, V36, P2678, DOI 10.1016/j.neurobiolaging.2015.06.029
   Leukes KLAM, 2023, Doctoral dissertation
   Leuthner TC, 2021, CURR ENV HLTH REP, V8, P294, DOI 10.1007/s40572-021-00329-1
   Lewis Matthew T, 2022, Methods Mol Biol, V2497, P141, DOI 10.1007/978-1-0716-2309-1_10
   Li N, 2023, CANCERS, V15, DOI 10.3390/cancers15030953
   Li SA, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/6617256
   Li W, 2022, REDOX BIOL, V55, DOI 10.1016/j.redox.2022.102421
   Li YA, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11050851
   Liang H, 2024, PHYTOTHER RES, V38, P1838, DOI 10.1002/ptr.8156
   Liang JL, 2021, FRONT AGING NEUROSCI, V13, DOI 10.3389/fnagi.2021.755665
   Lima JEBF, 2022, MUTAT RES-GEN TOX EN, V874, DOI 10.1016/j.mrgentox.2021.503437
   Lin JL, 2020, FREE RADICAL BIO MED, V150, P109, DOI 10.1016/j.freeradbiomed.2020.02.024
   Litwiniuk A, 2021, PHARMACEUTICALS-BASE, V14, DOI 10.3390/ph14121221
   Liu FT, 2023, PHENOMICS, V3, P22, DOI 10.1007/s43657-022-00077-8
   Liu H, 2022, BIOCHEM PHARMACOL, V197, DOI 10.1016/j.bcp.2021.114891
   Liu L, 2020, ANTIOXID REDOX SIGN, V32, P906, DOI 10.1089/ars.2019.8013
   Lohmeyer JL, 2021, AGING MENT HEALTH, V25, P832, DOI 10.1080/13607863.2020.1727851
   Loos B, 2017, PROG NEUROBIOL, V156, P90, DOI 10.1016/j.pneurobio.2017.05.001
   Lu YY, 2023, THERANOSTICS, V13, P736, DOI 10.7150/thno.79876
   Luciani A, 2021, CELL MOL LIFE SCI, V78, P6851, DOI 10.1007/s00018-021-03934-3
   Ma W, 2024, J ADV RES, V65, P297, DOI 10.1016/j.jare.2024.05.009
   Macdonald R, 2018, BIOCHEM SOC T, V46, P891, DOI 10.1042/BST20170501
   Malpartida AB, 2021, TRENDS BIOCHEM SCI, V46, P329, DOI 10.1016/j.tibs.2020.11.007
   Manczak M, 2010, J ALZHEIMERS DIS, V20, pS609, DOI 10.3233/JAD-2010-100564
   Mani S, 2021, MITOCHONDRION, V57, P270, DOI 10.1016/j.mito.2021.01.001
   Manolis AS, 2021, MED RES REV, V41, P275, DOI 10.1002/med.21732
   Medala VK, 2021, J NEUROSCI RES, V99, P1120, DOI 10.1002/jnr.24781
   Medina-Gómez G, 2012, BEST PRACT RES CL EN, V26, P791, DOI 10.1016/j.beem.2012.06.002
   Meng LX, 2024, SCI TOTAL ENVIRON, V929, DOI 10.1016/j.scitotenv.2024.172655
   Merchant TE, 2014, Normal Tissue Specific Sites and Systems, V2, P49, DOI [10.1007/978-3-540-75863-13, DOI 10.1007/978-3-540-75863-13]
   Mihajlovic M, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23063315
   Mishra E, 2023, BRIT J PHARMACOL, V180, P1542, DOI 10.1111/bph.16062
   Mito T, 2022, CELL METAB, V34, P197, DOI 10.1016/j.cmet.2021.12.017
   Moos WH, 2021, BIOCHEM PHARMACOL, V193, DOI 10.1016/j.bcp.2021.114809
   Muroi H, 2022, ANIM SCI J, V93, DOI 10.1111/asj.13677
   Musicco C, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19072076
   Naren P, 2023, J ALZHEIMERS DIS, V94, pS399, DOI 10.3233/JAD-220682
   Narendra D, 2012, CSH PERSPECT BIOL, V4, DOI 10.1101/cshperspect.a011338
   Neitemeier S, 2014, APOPTOSIS, V19, P1665, DOI 10.1007/s10495-014-1048-2
   Novak I, 2012, ANTIOXID REDOX SIGN, V17, P794, DOI 10.1089/ars.2011.4407
   Ntali G, 2019, PITUITARY, V22, P283, DOI 10.1007/s11102-019-00944-0
   Obeng E., 2021, Braz. J. Biol., V81, P1133
   Obukohwo Oyovwi Mega, 2024, Toxicol Rep, V12, P448, DOI 10.1016/j.toxrep.2024.04.004
   Obukohwo OM, 2023, ASIAN PAC J REPROD, V12, P97, DOI 10.4103/2305-0500.377500
   Oliver DMA, 2019, MOL CELL NEUROSCI, V96, P47, DOI 10.1016/j.mcn.2019.03.001
   Onishi M, 2021, FEBS LETT, V595, P1239, DOI 10.1002/1873-3468.14060
   Onyekweli CC, 2024, FOOD CHEM TOXICOL, V184, DOI 10.1016/j.fct.2023.114340
   Oyewole AO, 2015, FASEB J, V29, P4766, DOI 10.1096/fj.15-275404
   Oyovwi MO, 2022, NUTRIRE, V47, DOI 10.1186/s41110-022-00180-w
   Oyovwi MO, 2021, REPROD TOXICOL, V101, P50, DOI 10.1016/j.reprotox.2021.01.013
   Oyovwi MO, 2021, N-S ARCH PHARMACOL, V394, P717, DOI 10.1007/s00210-020-02003-z
   Oyovwi MO, 2024, N-S ARCH PHARMACOL, V397, P931, DOI 10.1007/s00210-023-02637-9
   Oyovwi MO., 2022, Biochem Anal Biochem, V11, P441
   Peng YJ, 2024, AGING DIS, V15, P1075, DOI 10.14336/AD.2023.0823-4
   Picard M, 2015, P NATL ACAD SCI USA, V112, pE6614, DOI 10.1073/pnas.1515733112
   Picca A, 2023, NAT METAB, V5, P2047, DOI 10.1038/s42255-023-00930-8
   Picca A, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9080647
   Qi YM, 2016, SCI REP-UK, V6, DOI 10.1038/srep24700
   Roberts FL, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10102639
   Rogers EM, 2024, DIABETES-METAB RES, V40, DOI 10.1002/dmrr.3667
   Sacks B, 2021, BMC PHARMACOL TOXICO, V22, DOI 10.1186/s40360-021-00518-6
   Salvador J, 2021, Endocrinol Syst Dis, P311, DOI [10.1007/978-3-319-66362-312-1, DOI 10.1007/978-3-319-66362-312-1]
   Sanchez-Garrido J, 2021, AUTOPHAGY, V17, P1571, DOI 10.1080/15548627.2020.1783119
   Schofield JH, 2021, ANTIOXID REDOX SIGN, V34, P517, DOI 10.1089/ars.2020.8058
   Sebori R, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/9179270
   Sharma P, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8020100
   Shinn LJ, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10040573
   Solesio ME, 2013, BBA-MOL BASIS DIS, V1832, P174, DOI 10.1016/j.bbadis.2012.07.009
   Song YM, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17010122
   Stefanova NA, 2016, AGING-US, V8, P2713, DOI 10.18632/aging.101054
   Stefanova NA, 2014, J ALZHEIMERS DIS, V38, P681, DOI 10.3233/JAD-131034
   Su ZQ, 2021, FRONT CELL DEV BIOL, V9, DOI 10.3389/fcell.2021.686820
   Tang MM, 2021, PHARMACOL RES, V168, DOI 10.1016/j.phrs.2021.105586
   Tang SK, 2024, FRONT PHYSIOL, V15, DOI 10.3389/fphys.2024.1339128
   Trigo D, 2022, FEBS LETT, V596, P1095, DOI 10.1002/1873-3468.14298
   Triolo M, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10051054
   Tryphena KP, 2023, MECH AGEING DEV, V211, DOI 10.1016/j.mad.2023.111800
   Tryphena KP, 2023, ACS CHEM NEUROSCI, V14, P1356, DOI 10.1021/acschemneuro.2c00819
   Um JH, 2017, BMB REP, V50, P299, DOI 10.5483/BMBRep.2017.50.6.056
   Uppala SN, 2023, MECH AGEING DEV, V213, DOI 10.1016/j.mad.2023.111826
   Van den Berghe G, 2016, AM J RESP CRIT CARE, V194, P1337, DOI 10.1164/rccm.201607-1516CI
   Vara-Perez M, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8050493
   Varesi A, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12010180
   Varghese N, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9100932
   Vásquez-Trincado C, 2016, J PHYSIOL-LONDON, V594, P509, DOI 10.1113/JP271301
   Victor E., 2023, Egyptian J Basic Appl Sci, V10, P733, DOI [10.1080/2314808X.2023.2254529, DOI 10.1080/2314808X.2023.2254529]
   Wang N, 2020, LIFE SCI, V259, DOI 10.1016/j.lfs.2020.118247
   Wang QX, 2022, FRONT MOL NEUROSCI, V15, DOI 10.3389/fnmol.2022.1014251
   Wang SL, 2023, SIGNAL TRANSDUCT TAR, V8, DOI 10.1038/s41392-023-01503-7
   Wang WW, 2020, CURR NEUROVASC RES, V17, P113, DOI 10.2174/1567202617666200225122620
   Wang XY, 2024, PHYTOTHER RES, V38, P3307, DOI 10.1002/ptr.8208
   Wang Y, 2024, DIABETES-METAB RES, V40, DOI 10.1002/dmrr.3733
   Wang Y, 2019, CNS NEUROSCI THER, V25, P859, DOI 10.1111/cns.13140
   Williamson J, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9111142
   Wohlgemuth SE, 2014, J MOL CELL CARDIOL, V71, P62, DOI 10.1016/j.yjmcc.2014.03.007
   Wu HK, 2020, AUTOPHAGY, V16, P683, DOI [10.1080/15548627.2019.1635380, 10.1080/15548627.2019.1596482]
   Xi Y, 2018, BBA-MOL BASIS DIS, V1864, P2859, DOI 10.1016/j.bbadis.2018.05.018
   Xiong XM, 2020, EXP CELL RES, V396, DOI 10.1016/j.yexcr.2020.112266
   Xu K, 2018, CELL PHYSIOL BIOCHEM, V46, P2031, DOI 10.1159/000489442
   Xu ST, 2021, FRONT CELL DEV BIOL, V9, DOI 10.3389/fcell.2021.688789
   Yang KC, 2018, BIOCHEM SOC T, V46, P97, DOI 10.1042/BST20170102
   Yang X, 2020, CLIN CHIM ACTA, V502, P245, DOI 10.1016/j.cca.2019.11.008
   Yip CK, 2010, MOL CELL, V38, P768, DOI 10.1016/j.molcel.2010.05.017
   Youle RJ, 2019, SCIENCE, V365, P655, DOI 10.1126/science.aaw9855
   Yu JJ, 2010, PHARMACOL RES, V62, P35, DOI 10.1016/j.phrs.2009.12.006
   Zhang JR, 2024, NAT COMMUN, V15, DOI 10.1038/s41467-024-49597-z
   Zhang LL, 2023, LIFE SCI, V322, DOI 10.1016/j.lfs.2023.121666
   Zhao YH, 2022, FREE RADICAL BIO MED, V182, P206, DOI 10.1016/j.freeradbiomed.2022.02.021
   Zhong ZF, 2018, DRUG DES DEV THER, V12, P1479, DOI 10.2147/DDDT.S160776
   Zimmermann A, 2024, EUR J CLIN INVEST, V54, DOI 10.1111/eci.14138
   Zong Y, 2024, SIGNAL TRANSDUCT TAR, V9, DOI 10.1038/s41392-024-01839-8
NR 201
TC 1
Z9 1
U1 3
U2 3
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0895-8696
EI 1559-1166
J9 J MOL NEUROSCI
JI J. Mol. Neurosci.
PD NOV 8
PY 2024
VL 74
IS 4
AR 107
DI 10.1007/s12031-024-02280-w
PG 30
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA L6E3R
UT WOS:001351625800001
PM 39514132
DA 2025-06-11
ER

PT J
AU Hsu, CH
   Tung, HH
   Clinciu, DL
   Chen, LK
   Yin, WH
   Iqbal, U
   Wang, TJ
AF Hsu, Ching Hwa
   Tung, Heng-Hsin
   Clinciu, Daniel L.
   Chen, Liang-Kung
   Yin, Wei-Hsian
   Iqbal, Usman
   Wang, Tsae-Jyy
TI Physical activity: A primary health quality determinant among
   community-dwelling geriatric women in Taiwan
SO INTERNATIONAL JOURNAL FOR QUALITY IN HEALTH CARE
LA English
DT Article
DE depression; frailty; healthcare quality; geriatric women
ID OLDER-PEOPLE; DEPRESSIVE SYMPTOMS; OF-CARE; FRAILTY; MORTALITY; RISK;
   LIFE; DEFINITION; COUNTRIES; ADULTS
AB Objective: To investigate the associations between frailty, physical activity and depression in community-dwelling geriatric women.
   Design: A cross-sectional research design.
   Setting: Community geriatric women in Illan County, Taiwan.
   Study participants: Of note 216 participants, 65 years and older with full mobility, independent and able to communicate in Mandarin or Taiwanese Hokkien.
   Main Outcome Measures: An average weekly physical activity score International Physical Activity Questionnaire-Short Form (IPAQ-SF) and Taiwan Geriatric Depression Scale. Classification and regression tree (CART) analysis was used to perform decision analysis.
   Results: The average IPAQ-SF score for the 216 participants was 9109.52. When an IPAQ-SF score of 4452 or below was obtained by participants, 38% of them encountered depression-like syndromes, regardless of their frailty status. Diabetes, high risk of metabolic syndrome and lower education were the risk factors found to cause depression among participants with low physical activity levels.
   Conclusions: As women have a longer life expectancy and experience twice the rates of depression of men particularly after menopause, healthcare providers should emphasize exercise and lifestyle changes in order to improve the quality of health in geriatric women.
C1 [Hsu, Ching Hwa; Yin, Wei-Hsian] Cheng Hsin Gen Hosp, Ctr Heart, Div Cardiol, 45 Cheng Hsin St Pei Tou, Taipei 11217, Taiwan.
   [Tung, Heng-Hsin; Wang, Tsae-Jyy] Natl Taipei Univ Nursing & Hlth Sci, 365 Ming Te Rd, Taipei 112, Taiwan.
   [Clinciu, Daniel L.] Natl Chi Nan Univ, Puli, Taiwan.
   [Clinciu, Daniel L.] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan.
   [Chen, Liang-Kung] Taipei Vet Gen Hosp, Ctr Geriatr & Gerontol, 201,Sect 2,Shi Pai Rd, Taipei 11217, Taiwan.
   [Iqbal, Usman] Taipei Med Univ, Coll Med Sci & Technol, Taipei, Taiwan.
C3 Cheng Hsin General Hospital; National Taipei University of Nursing &
   Health Science (NTUNHS); National Chi Nan University; China Medical
   University Taiwan; Taipei Veterans General Hospital; Taipei Medical
   University
RP Tung, HH (corresponding author), Natl Taipei Univ Nursing & Hlth Sci, 365 Ming Te Rd, Taipei 112, Taiwan.
EM shannontung719@gmail.com
RI Chen, Liang-Kung/JBI-8802-2023; Iqbal, Usman/L-2467-2016; Clinciu,
   Dan/HTT-4332-2023
OI Hsu, Ching-Hwa/0000-0002-9313-4424; Chen, Liang-Kung/0000-0002-2387-8508
CR Ahmed N, 2007, AM J MED, V120, P748, DOI 10.1016/j.amjmed.2006.10.018
   Avila-Funes JA, 2008, J GERONTOL A-BIOL, V63, P1089, DOI 10.1093/gerona/63.10.1089
   Almeida OP, 2015, J AM MED DIR ASSOC, V16, P296, DOI 10.1016/j.jamda.2014.10.023
   Bartley MM, 2016, J AM GERIATR SOC, V64, P132, DOI 10.1111/jgs.13821
   Binstock R.H., 1995, HDB AGING SOCIAL SCI
   Busch TD, 2015, BMC GERIATR, V15, DOI 10.1186/s12877-015-0031-2
   Cesari M, 2015, J GERONTOL A-BIOL, V70, P216, DOI 10.1093/gerona/glu099
   Chang C.M., 2003, Formosan Journal of Medicine, V7, P364, DOI [DOI 10.6320/FJM.2003.7(3).09, DOI 10.1016/S1878-7649(14)70070-1]
   Chen CY, 2010, ARCH GERONTOL GERIAT, V50, pS43, DOI 10.1016/S0167-4943(10)70012-1
   Demakakos P, 2010, DIABETES CARE, V33, P792, DOI 10.2337/dc09-1663
   Department of Information Service Executive Yuan, 2014, REP CHIN
   Ellekjær H, 2000, STROKE, V31, P14, DOI 10.1161/01.STR.31.1.14
   Fried LP, 2016, CSH PERSPECT MED, V6, DOI 10.1101/cshperspect.a025916
   Fried LP, 2001, J GERONTOL A-BIOL, V56, pM146, DOI 10.1093/gerona/56.3.M146
   Gobbens RJ, 2010, NURS OUTLOOK, V58, P76, DOI 10.1016/j.outlook.2009.09.005
   Hamerman D, 1999, ANN INTERN MED, V130, P945, DOI 10.7326/0003-4819-130-11-199906010-00022
   Harrison R, 2015, INT J QUAL HEALTH C, V27, P240, DOI 10.1093/intqhc/mzv041
   Hwang AC, 2015, REJUV RES, V18, P564, DOI 10.1089/rej.2015.1699
   Jensen HI, 2016, INT J QUAL HEALTH C, V28, P86, DOI 10.1093/intqhc/mzv108
   Khan KM, 2001, BRIT J SPORT MED, V35, P144, DOI 10.1136/bjsm.35.3.144
   Kuhn L, 2014, J ADV NURS, V70, P1276, DOI 10.1111/jan.12288
   Leng SX, 2004, AGING CLIN EXP RES, V16, P153
   Liou Y.M., 2004, DEV VERIFICATION VAL
   Liou Yiing Mei, 2008, J Nurs Res, V16, P252
   Lu BL., 2010, TAIWAN GERIATR GERON, V5, P36
   Park M, 2014, J IMMIGR MINOR HEALT, V16, P1103, DOI 10.1007/s10903-013-9926-1
   Rodríguez-Mañas L, 2013, J GERONTOL A-BIOL, V68, P62, DOI 10.1093/gerona/gls119
   Saleh S, 2015, INT J QUAL HEALTH C, V27, P79, DOI 10.1093/intqhc/mzu103
   Shin KR, 2009, PUBLIC HEALTH NURS, V26, P523, DOI 10.1111/j.1525-1446.2009.00812.x
   Tuomilehto J, 2001, NEW ENGL J MED, V344, P1343, DOI 10.1056/NEJM200105033441801
   Vaughan L, 2015, CLIN INTERV AGING, V10, DOI 10.2147/CIA.S69632
   Wada T, 2005, ARCH GERONTOL GERIAT, V41, P271, DOI 10.1016/j.archger.2005.03.003
   Williams ED, 2015, PSYCHOL MED, V45, P1861, DOI 10.1017/S0033291714002967
   Yu JH, 2017, AGING MENT HEALTH, V21, P823, DOI 10.1080/13607863.2016.1161007
   Zapantis G, 2003, BEST PRACT RES CL EN, V17, P33, DOI 10.1016/S1521-690X(02)00081-7
   Zwolinsky S, 2015, PUBLIC HEALTH, V129, P1630, DOI 10.1016/j.puhe.2015.07.015
NR 36
TC 9
Z9 10
U1 2
U2 23
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1353-4505
EI 1464-3677
J9 INT J QUAL HEALTH C
JI Int. J. Qual. Health Care
PD OCT
PY 2017
VL 29
IS 6
BP 792
EP 796
DI 10.1093/intqhc/mzx101
PG 5
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA FO5MJ
UT WOS:000416902800006
PM 29024954
OA Bronze
DA 2025-06-11
ER

PT J
AU Vuckovic, M
   Radic, J
   Gelemanovic, A
   Nenadic, DB
   Kolak, E
   Radic, M
AF Vuckovic, Marijana
   Radic, Josipa
   Gelemanovic, Andrea
   Nenadic, Dora Bucan
   Kolak, Ela
   Radic, Mislav
TI Associations between Depression, Nutritional Status and Mediterranean
   Diet in Dalmatian Kidney Transplant Recipients
SO NUTRIENTS
LA English
DT Article
DE depression; nutrition; nutritional status; Mediterranean diet; kidney
   transplant; Dalmatia
ID RENAL-TRANSPLANTATION; METABOLIC SYNDROME; SYMPTOMS; METAANALYSIS;
   OBESITY; WEIGHT
AB Depression has been addressed as a predictor of worse outcomes in kidney transplant recipients (KTRs). Nutritional status plays a great role in treatment of this population. The Mediterranean diet (MeDi) has been associated with lower levels of depressive symptoms. The aim of this cross-sectional study was to determine the rate of depression and its correlations to nutritional status and dietary habits according to the MeDi in Dalmatian KTRs. We included 115 KTRs, and data about body composition and anthropometric, laboratory and clinical parameters were obtained for each study participant. The Beck Depression Inventory-II (BDI-II) questionnaire was used to assess depressive symptoms and the Mediterranean Diet Serving Score (MDSS) was used to assess adherence to the MeDi. We found the presence of depressive symptoms in 21.73% of the Dalmatian KTRs. BDI-II score was reciprocally associated with fat mass, trunk visceral fat, anthropometric parameters of obesity, triglyceride levels and olive oil consumption. Inverse associations were found between BDI-II score and skeletal muscle mass, handgrip strength, MCV, hemoglobin levels and consumption of fish and white meat, as suggested by the MeDi. Our results showed the interconnections between nutritional status, dietary habits and depression in Dalmatian KTRs.
C1 [Vuckovic, Marijana; Radic, Josipa] Univ Hosp Ctr Split, Dept Nephrol & Dialysis, Split 21000, Croatia.
   [Radic, Josipa; Radic, Mislav] Univ Split, Dept Internal Med, Sch Med, Split 21000, Croatia.
   [Gelemanovic, Andrea] Mediterranean Inst Life Sci MedILS, Split 21000, Croatia.
   [Nenadic, Dora Bucan; Kolak, Ela] Univ Hosp Ctr Split, Dept Nutr & Dietet, Split 21000, Croatia.
   [Radic, Mislav] Univ Hosp Ctr Split, Dept Clin Immunol & Rheumatol, Split 21000, Croatia.
C3 University of Split; University of Split; University of Split;
   University of Split
RP Radic, J (corresponding author), Univ Hosp Ctr Split, Dept Nephrol & Dialysis, Split 21000, Croatia.; Radic, J (corresponding author), Univ Split, Dept Internal Med, Sch Med, Split 21000, Croatia.
EM mavuckovic@kbsplit.hr; josiparadic1973@gmail.com; mavuckovic@kbsplit.hr;
   josiparadic1973@gmail.com; andrea.gelemanovic@gmail.com;
   dorabucan@gmail.com
RI Gelemanović, Andrea/AAV-7338-2021; Radic, Josipa/H-3321-2017;
   Gelemanovic, Andrea/F-7218-2017; Radic, Mislav/H-3306-2017
OI Radic, Josipa/0000-0003-2645-7597; Gelemanovic,
   Andrea/0000-0001-9195-646X; Kolak, Ela/0000-0003-2012-9963; Radic,
   Mislav/0000-0003-0350-6800; Bucan Nenadic, Dora/0000-0002-2589-2266
FU project "Digitalization and improvement of nutritional care for patients
   with chronic diseases"
FX FundingThis study is part of the project Digitalization and improvement
   of nutritional care for patients with chronic diseases co-financed by
   the European Regional Development Fund through the Operational Program
   Competitiveness and Cohesion 20142020 KK.01.1.1.04.0115.
CR Chilcot J, 2014, TRANSPLANTATION, V97, P717, DOI 10.1097/01.TP.0000438212.72960.ae
   Cukor D, 2009, KIDNEY INT, V75, P1223, DOI 10.1038/ki.2009.51
   Czira ME, 2011, GEN HOSP PSYCHIAT, V33, P157, DOI 10.1016/j.genhosppsych.2011.01.012
   De Pasquale C, 2020, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.00106
   Dobersek U, 2021, CRIT REV FOOD SCI, V61, P622, DOI 10.1080/10408398.2020.1741505
   Fardeazar FE, 2018, ELECTRON J GEN MED, V15, DOI 10.29333/ejgm/93460
   Gomes-Neto AW, 2020, CLIN J AM SOC NEPHRO, V15, P238, DOI 10.2215/CJN.06710619
   Grosso G, 2016, J AFFECT DISORDERS, V205, P269, DOI 10.1016/j.jad.2016.08.011
   Hori S, 2019, TRANSPL P, V51, P1763, DOI 10.1016/j.transproceed.2019.04.047
   Jia QF, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-77782-9
   Kazemi S, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.710555
   Kurita N, 2021, J NUTR HEALTH AGING, V25, P593, DOI 10.1007/s12603-020-1556-4
   Kursa MB, 2010, J STAT SOFTW, V36, P1, DOI 10.18637/jss.v036.i11
   Lee HS, 2020, BMC PSYCHIATRY, V20, DOI 10.1186/s12888-020-02621-0
   Lee MR, 2018, BMC PUBLIC HEALTH, V18, DOI 10.1186/s12889-018-6030-4
   Lentine KL, 2008, TRANSPLANTATION, V86, P303, DOI 10.1097/TP.0b013e31817ef0f9
   Marques A, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17165674
   Milano W, 2020, DISEASES-BASEL, V8, DOI 10.3390/diseases8020023
   Monteagudo C, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0128594
   Nafar M, 2009, KIDNEY INT, V76, P1199, DOI 10.1038/ki.2009.343
   Nöhre M, 2020, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.00399
   Novak M, 2010, PSYCHOSOM MED, V72, P527, DOI 10.1097/PSY.0b013e3181dbbb7d
   Oliván-Blázquez B, 2021, NUTRIENTS, V13, DOI 10.3390/nu13082724
   Osté MCJ, 2017, BMJ OPEN DIAB RES CA, V5, DOI 10.1136/bmjdrc-2016-000283
   Palmer S, 2013, KIDNEY INT, V84, P179, DOI 10.1038/ki.2013.77
   Parletta N, 2019, NUTR NEUROSCI, V22, P474, DOI 10.1080/1028415X.2017.1411320
   Piotti G, 2019, NEPHROL DIAL TRANSPL, V34, P388, DOI 10.1093/ndt/gfy151
   Ponticelli C, 2021, J PERS MED, V11, DOI 10.3390/jpm11090927
   R Core Team, 2020, R LANG ENV STAT COMP
   Ronai KZ, 2017, J CLIN SLEEP MED, V13, P557, DOI 10.5664/jcsm.6542
   Sabbatini M, 2019, NUTR METAB CARDIOVAS, V29, P319, DOI 10.1016/j.numecd.2019.01.002
   Sánchez-Villegas A, 2018, NUTRIENTS, V10, DOI 10.3390/nu10122000
   Sánchez-Villegas A, 2016, CLIN PSYCHOL SCI, V4, P1085, DOI 10.1177/2167702616638651
   Shelton Richard C, 2011, Dialogues Clin Neurosci, V13, P41
   Shelton RC, 2010, PROG NEUROBIOL, V91, P275, DOI 10.1016/j.pneurobio.2010.04.004
   Speed MS, 2019, TRANSL PSYCHIAT, V9, DOI 10.1038/s41398-019-0516-4
   Stanfill A, 2016, PROG TRANSPLANT, V26, P70, DOI 10.1177/1526924816632118
   Stanfill A, 2012, PROG TRANSPLANT, V22, P71, DOI 10.7182/pit2012986
   Szeifert L, 2010, AM J KIDNEY DIS, V55, P132, DOI 10.1053/j.ajkd.2009.09.022
   Tantisattamo E, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.709644
   Vuckovic M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13093246
   Wang HC, 2021, NUTRITION, V86, DOI 10.1016/j.nut.2021.111157
   Wissing KM, 2014, TRANSPLANT REV-ORLAN, V28, P37, DOI 10.1016/j.trre.2013.12.004
   Yun H, 2021, NUTRIENTS, V13, DOI 10.3390/nu13041360
   Zelle DM, 2012, TRANSPLANTATION, V94, P1033, DOI 10.1097/TP.0b013e31826bc3c8
NR 45
TC 6
Z9 6
U1 1
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2021
VL 13
IS 12
AR 4479
DI 10.3390/nu13124479
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA XX9KX
UT WOS:000736606100001
PM 34960031
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rameshrad, M
   Razavi, BM
   Imenshahidi, M
   Hosseinzadeh, H
AF Rameshrad, Maryam
   Razavi, Bibi Marjan
   Imenshahidi, Mohsen
   Hosseinzadeh, Hossein
TI Vitis vinifera (grape) seed extract and resveratrol alleviate
   bisphenol-A-induced metabolic syndrome: Biochemical and molecular
   evidences
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE bisphenol A; dyslipidemia; grape; hypertension; metabolic syndrome;
   resveratrol
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; ADIPOSE-TISSUE; GREEN TEA;
   MECHANISMS; EXPOSURE; GLUCOSE; ATHEROSCLEROSIS; OBESITY; CROCIN
AB The mechanisms of bisphenol-A (BPA)-induced metabolic syndrome as well as the protective role of grape seed extract (GSE) and resveratrol were investigated. Rats were treated with BPA (0 and 35 mg.kg(-1).day(-1), gavage) plus resveratrol (25, 50, and 100 mg.kg(-1) .day(-1), i.p.) or GSE (3, 6, 12 mg.kg(-1).day(-1), i.p.) or vitamin E (200 IU/kg/every other day, i.p.). After 2 months, mean systolic blood pressure, serum lipid profile, glycaemia, and fat index were examined. By enzyme-linked immunosorbent assay, the serum concentrations of insulin, leptin, adiponectin, and paraoxonase 1, and by real-time polymerase chain reaction as well as western blotting, key liver elements in cholesterol hemostasis (LDLR, CYP7A1, ABCG5 and 8) and insulin signaling (p-Akt/Akt and p-PI3K/PI3K) were measured. BPA increased mean systolic blood pressure, total cholesterol, and low-density lipoprotein cholesterol and reduced paraoxonase1 and the hepatic expression of both ABCG5 and ABCG8. It increased the body fat index, leptin, adiponectin, insulin, and glycaemia level and decreased the hepatic protein expression of p-Akt/Akt and p-PI3K/PI3k. GSE, resveratrol, or vitamin E coadministration along with BPA restored the detrimental effects of BPA in some levels. Herein, the predisposing effects of BPA-induced metabolic syndrome were restored by GSE and resveratrol, linked to the regulation of insulin signaling, ABCG8 expression, and their antioxidant properties.
C1 [Rameshrad, Maryam; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran.
   [Razavi, Bibi Marjan] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Targeted Drug Delivery Res Ctr, Mashhad, Iran.
   [Razavi, Bibi Marjan; Imenshahidi, Mohsen; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran.
EM hosseinzadehh@mums.ac.ir
RI rameshrad, maryam/D-1624-2019; razavi, Bibi Marjan/AAY-5636-2020;
   Hosseinzadeh, Hossein/F-3013-2010
OI rameshrad, maryam/0000-0001-6822-8552; razavi, Bibi
   Marjan/0000-0002-7450-9286; Hosseinzadeh, Hossein/0000-0002-3483-851X
FU Iran National Science Foundation [95004557]; Mashhad University of
   Medical Sciences [941389]
FX Iran National Science Foundation, Grant/Award Numbers: 95004557, NO.
   95004557; Research Vice Chancellors of Mashhad University of Medical
   Sciences, Grant/Award Numbers: 941389, NO. 941389
CR Adisakwattana S, 2010, J MED PLANTS RES, V4, P2113
   Ailhaud G, 2006, CR BIOL, V329, P570, DOI 10.1016/j.crvi.2005.12.012
   Akaberi M, 2016, PHYTOTHER RES, V30, P540, DOI 10.1002/ptr.5570
   Alonso-Magdalena P, 2006, ENVIRON HEALTH PERSP, V114, P106, DOI 10.1289/ehp.8062
   Aprahamian TR, 2011, INT J INFLAMM, V2011, DOI 10.4061/2011/376909
   Berg AH, 2001, NAT MED, V7, P947, DOI 10.1038/90992
   Berrougui H, 2009, ATHEROSCLEROSIS, V207, P420, DOI 10.1016/j.atherosclerosis.2009.05.017
   Bouayed J, 2010, OXID MED CELL LONGEV, V3, P228, DOI 10.4161/oxim.3.4.12858
   Chung JH, 2003, FASEB J, V17, P1913, DOI 10.1096/fj.02-0914fje
   Collins B, 2016, J NUTR BIOCHEM, V31, P150, DOI 10.1016/j.jnutbio.2015.12.021
   da Costa GF, 2017, PHYTOTHER RES, V31, P1621, DOI 10.1002/ptr.5898
   DENNISSYKES CA, 1985, J BIOL STAND, V13, P309, DOI 10.1016/S0092-1157(85)80044-5
   Emiliano AF, 2011, J CARDIOVASC PHARM, V58, P319, DOI 10.1097/FJC.0b013e3182244a51
   Fang C, 2015, J APPL TOXICOL, V35, P1058, DOI 10.1002/jat.3103
   Fang C, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0110977
   Fiege H., 2000, Ullmann's Encyclopedia of Industrial Chemistry, DOI [10.1002/14356007.a19313, DOI 10.1002/14356007.A19313]
   Fülöp P, 2016, CHEM-BIOL INTERACT, V259, P388, DOI 10.1016/j.cbi.2016.04.003
   Gao XQ, 2014, INT J ENV RES PUB HE, V11, P8399, DOI 10.3390/ijerph110808399
   Ha SK, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/6846084
   Hassani FV, 2018, FOOD CHEM TOXICOL, V112, P26, DOI 10.1016/j.fct.2017.12.021
   Hassani FV, 2016, N-S ARCH PHARMACOL, V389, P931, DOI 10.1007/s00210-016-1256-0
   Hassani FV, 2017, FOOD CHEM TOXICOL, V107, P395, DOI 10.1016/j.fct.2017.07.007
   Hosseini A, 2015, J ENDOCRINOL INVEST, V38, P1147, DOI 10.1007/s40618-015-0313-8
   Hou RR, 2008, CELL BIOL INT, V32, P22, DOI 10.1016/j.cellbi.2007.08.007
   Ikonen E, 2006, PHYSIOL REV, V86, P1237, DOI 10.1152/physrev.00022.2005
   Jayashree S, 2013, ENVIRON TOXICOL PHAR, V35, P300, DOI 10.1016/j.etap.2012.12.016
   Kim MJ, 2014, CARDIOVASC TOXICOL, V14, P120, DOI 10.1007/s12012-013-9235-x
   Koch HM, 2009, PHILOS T R SOC B, V364, P2063, DOI 10.1098/rstb.2008.0208
   Lari P, 2014, Drug Res (Stuttg), V64, P301, DOI 10.1055/s-0033-1357196
   Leifert WR, 2008, NUTR RES, V28, P729, DOI [10.1016/j.nutres.2008.08.007, 10.1016/j.nutres.2008.09.001]
   Lim CC, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0122009
   Lind PM, 2011, ATHEROSCLEROSIS, V218, P207, DOI 10.1016/j.atherosclerosis.2011.05.001
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   Lorenz JN, 2002, AM J PHYSIOL-REG I, V282, pR1565, DOI 10.1152/ajpregu.00759.2001
   Mann Adrien, 2014, J Vis Exp, DOI 10.3791/52174
   Menale C., 2016, The Open Biotechnology Journal, V10, P122, DOI [DOI 10.1021/tx025548t, 10.2174/1874070701610010122, DOI 10.2174/1874070701610010122]
   Miura D, 2003, LIFE SCI, V73, P1393, DOI 10.1016/S0024-3205(03)00469-7
   Moghaddam HS, 2015, TOXICOL MECH METHOD, V25, P507, DOI 10.3109/15376516.2015.1056395
   Mollazadeh H, 2016, IRAN J BASIC MED SCI, V19, P1258, DOI 10.22038/ijbms.2016.7906
   Moreno DA, 2003, NUTRITION, V19, P876, DOI 10.1016/S0899-9007(03)00167-9
   Nassiri-Asl M, 2016, PHYTOTHER RES, V30, P1392, DOI 10.1002/ptr.5644
   Nassiri-Asl M, 2009, PHYTOTHER RES, V23, P1197, DOI 10.1002/ptr.2761
   Nie GJ, 2002, ARCH BIOCHEM BIOPHYS, V397, P84, DOI 10.1006/abbi.2001.2636
   Oueslati N, 2016, BIOMED PHARMACOTHER, V83, P584, DOI 10.1016/j.biopha.2016.07.024
   Pahlavani M, 2017, J INVEST MED, V65, P1021, DOI 10.1136/jim-2017-000535
   Razavi BM, 2017, BIOMED PHARMACOTHER, V92, P726, DOI 10.1016/j.biopha.2017.05.113
   Razavi BM, 2017, J SCI FOOD AGR, V97, P1679, DOI 10.1002/jsfa.8134
   Razavi BM, 2014, DRUG CHEM TOXICOL, V37, P378, DOI 10.3109/01480545.2013.866139
   Sadi G, 2015, GENE, V570, P213, DOI 10.1016/j.gene.2015.06.019
   Shandiz HT, 2017, PHYTOTHER RES, V31, P1173, DOI 10.1002/ptr.5862
   Shankar A, 2012, J ENVIRON PUBLIC HEA, V2012, DOI 10.1155/2012/481641
   Shankar A, 2011, J CLIN ENDOCR METAB, V96, P3822, DOI 10.1210/jc.2011-1682
   Somm E, 2009, ENVIRON HEALTH PERSP, V117, P1549, DOI 10.1289/ehp.11342
   Stojanoska MM, 2017, ENDOCRINE, V55, P666, DOI 10.1007/s12020-016-1158-4
   Sui YP, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.113.000492
   Tabeshpour J, 2017, IRAN J BASIC MED SCI, V20, P557, DOI 10.22038/IJBMS.2017.8682
   Tabeshpour J, 2017, PHYTOTHER RES, V31, P819, DOI 10.1002/ptr.5805
   Tajmohammadi A, 2018, PHYTOTHER RES, V32, P1933, DOI 10.1002/ptr.6153
   Vandenberg LN, 2007, REPROD TOXICOL, V24, P139, DOI 10.1016/j.reprotox.2007.07.010
   Vayupharp B., 2012, Journal of Food Processing and Technology, V3, P152
   Wang S, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-77
   Wang TG, 2012, J CLIN ENDOCR METAB, V97, pE223, DOI 10.1210/jc.2011-1989
   Wetherill YB, 2007, REPROD TOXICOL, V24, P178, DOI 10.1016/j.reprotox.2007.05.010
   Yamauchi T, 2002, NAT MED, V8, P1288, DOI 10.1038/nm788
NR 65
TC 20
Z9 20
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD MAR
PY 2019
VL 33
IS 3
BP 832
EP 844
DI 10.1002/ptr.6276
PG 13
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HO6UH
UT WOS:000461067400033
PM 30653759
DA 2025-06-11
ER

PT J
AU Panahi, Y
   Ostadmohammadi, V
   Raygan, F
   Sharif, MR
   Sahebkar, A
AF Panahi, Yunes
   Ostadmohammadi, Vahidreza
   Raygan, Fariba
   Sharif, Mohammad Reza
   Sahebkar, Amirhossein
TI The effects of N-acetylcysteine administration on metabolic status and
   serum adiponectin levels in patients with metabolic syndrome: A
   randomized, double-blind, placebo-controlled trial
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE N-acetylcysteine; Metabolic status; Metabolic syndrome; Oxidative
   stress; Inflammation
ID ACETYL-L-CYSTEINE; OXIDATIVE STRESS; INFLAMMATORY RESPONSE; INSULIN
   SENSITIVITY; METFORMIN; WOMEN; SUPPLEMENTATION; MALONDIALDEHYDE;
   GLUTATHIONE; ACTIVATION
AB Objective: This study examined the impact of N-acetylcysteine (NAC) administration on metabolic parameters and serum adiponectin levels in individuals with metabolic syndrome (MetS).Methods: This randomized clinical trial included 76 people with MetS, aged 25-75 years. Participants were randomly assigned to receive either 1800 mg/day NAC (n = 38) or matched placebo (n = 38) for 12 weeks. Fasting blood samples were collected at the onset and at the end of 12-week intervention to quantify metabolic parameters. Results: NAC significantly reduced fasting plasma glucose (P = 0.02), fasting serum insulin (P = 0.006), insulin resistance index (P = 0.005), and serum C-reactive protein (P = 0.003), and increased serum HDL-cholesterol (P = 0.001) and plasma total glutathione (P < 0.001) versus the placebo group. NAC administration did not alter adiponectin, blood pressure, other lipid indices, malondialdehyde, and total antioxidant capacity. Conclusions: Overall, 1800 mg/day NAC consumption for 12 weeks in MetS subjects had positive impacts on the parameters of glycemic homeostasis, HDL-cholesterol, inflammatory status, and body antioxidative defense system. NAC prescription may be a new strategy for the amelioration of metabolic parameters in individuals with MetS.Clinical Trial Registration: This clinical trial was prospectively registered in the Iranian website for registration of clinical trials (https://www.irct.ir/trial/44284).
C1 [Panahi, Yunes] Baqiyatallah Univ Med Sci, Sch Pharm, Pharmacotherapy Dept, Tehran, Iran.
   [Ostadmohammadi, Vahidreza; Raygan, Fariba] Kashan Univ Med Sci, Fac Med, Dept Internal Med, Kashan, Iran.
   [Ostadmohammadi, Vahidreza; Sharif, Mohammad Reza] Kashan Univ Med Sci, Infect Dis Res Ctr, Kashan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Dept Biotechnol, Mashhad, Iran.
C3 Baqiyatallah University of Medical Sciences (BMSU); Mashhad University
   of Medical Sciences; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences
RP Panahi, Y (corresponding author), Baqiyatallah Univ Med Sci, Sch Pharm, Pharmacotherapy Dept, Tehran, Iran.; Ostadmohammadi, V (corresponding author), Kashan Univ Med Sci, Fac Med, Dept Internal Med, Kashan, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
EM yunespanahi@yahoo.com; vrom.1993@gmail.com; amir_saheb2000@yahoo.com
RI Raygan, Fariba/W-3349-2017; Sahebkar, Amirhossein/B-5124-2018;
   Ostadmohammadi, Vahidreza/A-6248-2018; Sharif, Mohammad
   Reza/GWQ-8947-2022
OI Ostadmohammadi, Vahidreza/0000-0002-4633-5397; Sharif, Mohammad
   Reza/0000-0002-2049-3370
CR Akbay E, 2019, KARDIOCHIR TORAKOCHI, V16, P88, DOI 10.5114/kitp.2019.86361
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Askari M, 2020, CYTOKINE, V135, DOI 10.1016/j.cyto.2020.155239
   Benzie IFF, 1996, ANAL BIOCHEM, V239, P70, DOI 10.1006/abio.1996.0292
   BEUTLER E, 1985, J LAB CLIN MED, V105, P581
   Bryan S, 2013, CAN J PHYSIOL PHARM, V91, P22, DOI 10.1139/cjpp-2012-0295
   Calzadilla P, 2011, INT J MOL SCI, V12, P6936, DOI 10.3390/ijms12106936
   Castaño-Martinez T, 2019, FASEB J, V33, P7092, DOI 10.1096/fj.201900150R
   Chandil N, 2019, J OBSTET GYN INDIA, V69, P77, DOI 10.1007/s13224-018-1135-3
   Chen SS, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0050456, 10.1371/journal.pone.0049275, 10.1371/journal.pone.0045763, 10.1371/journal.pone.0036784]
   Csontos C, 2012, BURNS, V38, P428, DOI 10.1016/j.burns.2011.09.011
   Dludla PV, 2019, PHARMACOL RES, V146, DOI 10.1016/j.phrs.2019.104332
   El Sharkwy IA, 2019, INT J GYNECOL OBSTET, V147, P59, DOI 10.1002/ijgo.12902
   Elshorbagy AK, 2013, METABOLISM, V62, P509, DOI 10.1016/j.metabol.2012.10.005
   Faghfouri AH, 2020, EUR J PHARMACOL, V884, DOI 10.1016/j.ejphar.2020.173368
   Falach-Malik A, 2016, AM J TRANSL RES, V8, P3744
   Fulghesu AM, 2002, FERTIL STERIL, V77, P1128, DOI 10.1016/S0015-0282(02)03133-3
   Gavia-García G, 2021, BIOLOGY-BASEL, V10, DOI 10.3390/biology10040253
   Gluvic Z, 2017, CURR VASC PHARMACOL, V15, P30, DOI 10.2174/1570161114666161007164510
   Gradinaru D, 2017, AGING CLIN EXP RES, V29, P621, DOI 10.1007/s40520-016-0629-z
   Gustafsson S, 2013, OBESITY, V21, P1467, DOI 10.1002/oby.20097
   Hashemi G, 2019, CURR RHEUMATOL REV, V15, P246, DOI 10.2174/1573403X14666180926100811
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   JANERO DR, 1990, FREE RADICAL BIO MED, V9, P515, DOI 10.1016/0891-5849(90)90131-2
   Javanmanesh F, 2016, GYNECOL ENDOCRINOL, V32, P285, DOI 10.3109/09513590.2015.1115974
   Jeremias A, 2009, HEART INT, V4, P25, DOI 10.4081/hi.2009.e7
   Kashi EA, 2022, SURG OPEN SCI, V10, P69, DOI 10.1016/j.sopen.2022.06.006
   Kuruganti PA, 2002, J NEURO-ONCOL, V56, P109, DOI 10.1023/A:1014530309082
   Mahapatra SK, 2011, INT IMMUNOPHARMACOL, V11, P485, DOI 10.1016/j.intimp.2010.12.020
   de Oliveira CPMS, 2008, HEPATOL RES, V38, P159, DOI 10.1111/j.1872-034X.2007.00215.x
   Martínez Y, 2017, AMINO ACIDS, V49, P2091, DOI 10.1007/s00726-017-2494-2
   Michailidis Y, 2013, AM J CLIN NUTR, V98, P233, DOI 10.3945/ajcn.112.049163
   Milewicz A, 2010, MATURITAS, V65, P272, DOI 10.1016/j.maturitas.2009.11.008
   Mokhtari V, 2017, CELL J, V19, P11
   Muniroh M, 2020, REV ENVIRON HEALTH, V35, P233, DOI 10.1515/reveh-2020-0026
   Oner G, 2011, EUR J OBSTET GYN R B, V159, P127, DOI 10.1016/j.ejogrb.2011.07.005
   Padmalayam I, 2013, CURR PHARM DESIGN, V19, P5755, DOI 10.2174/13816128113199990360
   Panizzutti B, 2018, ACTA NEUROPSYCHIATR, V30, P334, DOI 10.1017/neu.2018.13
   Paschalis V, 2018, FREE RADICAL BIO MED, V115, P271, DOI 10.1016/j.freeradbiomed.2017.12.007
   Pisprasert V, 2013, DIABETES CARE, V36, P845, DOI 10.2337/dc12-0840
   Purwanto Bambang, 2012, Acta Med Indones, V44, P140
   Rani M, 2020, METAB SYNDR RELAT D, V18, P341, DOI 10.1089/met.2020.0017
   Rask-Madsen C, 2012, ARTERIOSCL THROM VAS, V32, P2052, DOI 10.1161/ATVBAHA.111.241919
   Recinella L, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.578966
   Rezatabar S, 2019, J CELL PHYSIOL, V234, P14951, DOI 10.1002/jcp.28334
   Sadowska AM, 2007, PULM PHARMACOL THER, V20, P9, DOI 10.1016/j.pupt.2005.12.007
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Silva LA, 2008, INT J SPORT NUTR EXE, V18, P379, DOI 10.1123/ijsnem.18.4.379
   Tamakoshi K, 2007, CLIN ENDOCRINOL, V66, P65, DOI 10.1111/j.1365-2265.2006.02687.x
   Trimarchi H, 2003, CLIN NEPHROL, V59, P441
   Vural A, 2018, PERITON DIALYSIS INT, V38, P57, DOI 10.3747/pdi.2017.00133
   Wang LF, 2020, BBA-MOL BASIS DIS, V1866, DOI 10.1016/j.bbadis.2020.165908
   YANG Y, 2021, FOODS BASEL SWITZERL, DOI DOI 10.3390/FOODS10102439
   Yuan GY, 2016, ENDOCR J, V63, P655, DOI 10.1507/endocrj.EJ16-0078
   Zhang QW, 2018, MEDICINE, V97, DOI [10.1097/MD.0000000000013087, 10.1097/md.0000000000013087]
   Zhang ZZ, 2019, MOL MED REP, V20, P4349, DOI 10.3892/mmr.2019.10678
NR 56
TC 7
Z9 7
U1 0
U2 13
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD DEC
PY 2022
VL 99
AR 105299
DI 10.1016/j.jff.2022.105299
EA OCT 2022
PG 6
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 6Q8DC
UT WOS:000891839200002
OA gold
DA 2025-06-11
ER

PT J
AU Kang, HT
   Linton, JA
   Shim, JY
AF Kang, Hee-Taik
   Linton, John A.
   Shim, Jae-Yong
TI Serum ferritin level is associated with the prevalence of metabolic
   syndrome in Korean adults: The 2007-2008 Korean National Health and
   Nutrition Examination Survey
SO CLINICA CHIMICA ACTA
LA English
DT Article
DE Ferritin; Insulin resistance; Inflammation; Oxidative stress; Metabolic
   syndrome
ID CARDIOVASCULAR RISK-FACTORS; C-REACTIVE PROTEIN; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; PLASMA-MEMBRANE; IRON STORES; DISEASE; MEN;
   INFLAMMATION; OBESITY
AB Background: Increased ferritin concentrations, which reflect body iron stores, contribute to insulin dysfunction and metabolic syndrome (MetS).
   Methods: This cross-sectional study included 7346 subjects (3229 men and 4117 women) who participated in the 2007-2008 Korean National Health and Nutrition Examination Survey (KNHANES). We adopted the modified Asian criteria for MetS from the American Heart Association/National Heart, Lung, and Blood Institute.
   Results: In comparison with participants in the first serum ferritin quartile, the odds ratio (95% confidence interval) for MetS for participants in the fourth serum ferritin quartile was 1.67 (1.24-2.23) in men and 1.41 (1.06-1.88) in women after adjusting for multiple covariates (including menopausal status in women) except insulin resistance. This association was attenuated, however, after additionally adjusting for insulin resistance (1.46 (1.08-1.98) in men and 1.22 (0.91-1.65) in women]. In particular, higher serum ferritin concentrations were associated with increased triglyceride concentrations in men and glucose intolerance in women.
   Conclusions: Increased serum ferritin level was positively associated with the prevalence of MetS and with some diagnostic components of MetS, i.e., we found that increased serum ferritin concentrations were associated with high triglyceride and glucose concentrations in men and women, respectively. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Kang, Hee-Taik; Shim, Jae-Yong] Yonsei Univ, Coll Med, Dept Family Med, Gangnam Severance Hosp, Seoul, South Korea.
   [Kang, Hee-Taik] Yonsei Univ, Dept Med, Grad Sch, Seoul 120749, South Korea.
   [Linton, John A.] Yonsei Univ, Coll Med, Severance Hosp, Int Hlth Care Ctr, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University; Yonsei University Health System
RP Shim, JY (corresponding author), Yonsei Univ, Coll Med, Dept Family Med, 712 Eonju Ro, Seoul, South Korea.
EM hope@yuhs.ac
RI Shim, Jae Yong/GLU-2862-2022
OI Kang, Hee-Taik/0000-0001-8048-6247; Shim, JaeYong/0000-0002-9561-9230;
   Linton, John/0000-0001-8000-3049
CR DAVIS RJ, 1986, J BIOL CHEM, V261, P8708
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Evans JL, 2005, ANTIOXID REDOX SIGN, V7, P1040, DOI 10.1089/ars.2005.7.1040
   Fearon IM, 2009, J MOL CELL CARDIOL, V47, P372, DOI 10.1016/j.yjmcc.2009.05.013
   Ferrannini E, 2000, LANCET, V355, P2181, DOI 10.1016/S0140-6736(00)02397-7
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gabay C, 1999, NEW ENGL J MED, V340, P448, DOI 10.1056/NEJM199902113400607
   Gillum RF, 2001, INT J OBESITY, V25, P639, DOI 10.1038/sj.ijo.0801561
   González AS, 2006, EUR J CLIN NUTR, V60, P802, DOI 10.1038/sj.ejcn.1602384
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Halle M, 1997, ATHEROSCLEROSIS, V128, P235, DOI 10.1016/S0021-9150(96)05994-1
   Jehn M, 2004, DIABETES CARE, V27, P2422, DOI 10.2337/diacare.27.10.2422
   Jiang R, 2004, JAMA-J AM MED ASSOC, V291, P711, DOI 10.1001/jama.291.6.711
   Kim CH, 2011, METABOLISM, V60, P414, DOI 10.1016/j.metabol.2010.03.007
   Lann D, 2007, MED CLIN N AM, V91, P1063, DOI 10.1016/j.mcna.2007.06.012
   Lee JY, 2000, J KOREAN MED SCI, V15, P179, DOI 10.3346/jkms.2000.15.2.179
   Mateo-Gallego R, 2010, METABOLISM, V59, P154, DOI 10.1016/j.metabol.2009.06.021
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   MERKEL PA, 1988, NEW ENGL J MED, V318, P809, DOI 10.1056/NEJM198803313181303
   MUKHERJEE SP, 1977, ARCH BIOCHEM BIOPHYS, V184, P69, DOI 10.1016/0003-9861(77)90327-7
   Piperno A, 2002, J HYPERTENS, V20, P1513, DOI 10.1097/00004872-200208000-00013
   Rutter MK, 2004, CIRCULATION, V110, P380, DOI 10.1161/01.CIR.0000136581.59584.0E
   Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
   Williams MJA, 2002, ATHEROSCLEROSIS, V165, P179, DOI 10.1016/S0021-9150(02)00233-2
   Wilson JG, 2003, AM J MED SCI, V325, P332, DOI 10.1097/00000441-200306000-00004
   Yao DC, 2005, FREE RADICAL BIO MED, V39, P1385, DOI 10.1016/j.freeradbiomed.2005.07.015
   Yoon YS, 2007, INT J OBESITY, V31, P528, DOI 10.1038/sj.ijo.0803442
NR 28
TC 40
Z9 42
U1 0
U2 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0009-8981
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD MAR 22
PY 2012
VL 413
IS 5-6
BP 636
EP 641
DI 10.1016/j.cca.2011.12.011
PG 6
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 961UW
UT WOS:000305496000020
PM 22212623
DA 2025-06-11
ER

PT J
AU Sebeková, K
   Boor, P
   Valachovicová, M
   Blazícek, P
   Parrák, V
   Babinská, K
   Heidland, A
   Krajcovicová-Kudlácková, M
AF Sebekova, Katarina
   Boor, Peter
   Valachovicova, Martina
   Blazicek, Pavol
   Parrak, Vojtech
   Babinska, Katarina
   Heidland, August
   Krajcovicova-Kudlackova, Marica
TI Association of metabolic syndrome risk factors with selected markers of
   oxidative status and microinflammation in healthy omnivores and
   vegetarians
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE advanced glycation end products; advanced oxidation protein products;
   inflammation; metabolic syndrome risk factors; oxidative status
ID C-REACTIVE PROTEIN; GLYCATION END-PRODUCTS; INSULIN SENSITIVITY;
   BETA-CAROTENE; VITAMIN-E; EXERCISE INTERVENTION; KAPPA-B; ANTIOXIDANT;
   STRESS; PLASMA
AB Conditions predisposing to metabolic syndrome (MetS) are associated with increased oxidative stress and inflammation. We studied, in vegetarians (n = 90) and omnivores (n = 46), the impact of the dietary regimen on the occurrence of MetS risk factors (RFs: BMI, blood pressure, glucose metabolism and lipid profile) in relation to oxidative status (advanced glycation end products (AGEs), advanced oxidation protein products (AOPPs), malondialdehyde, ferric reducing ability of plasma, vitamins A, E, C, beta-carotene and superoxide dismutase activity) and microinflammation (C-reactive protein, leukocytes and neopterin). The proportion of subjects without/positive for one or two MetS RFs was comparable between the groups. From the components of MetS only immunoreactive insulin levels differed significantly (95% Cl: omnivores: 5.0-7.1 mu U/mL, vegetarians: 4.5-5.4,p = 0.03). Omnivores had lower AOPP (omnivores: 0.29-0.36 mu mol/g albumin, vegetarians: 0.36-0.52, p = 0.01) and beta-carotene levels than vegetarians, they consumed more calories, proteins, fat and saturated fatty acids, and less fibres, beta-carotene and vitamin C. Multiple regression analysis revealed vitamin E and AOPP levels as the most important independent determinants of MetS RFs. The vegetarian diet seems to exert beneficial effects on MetS RFs associated microinflammation. Whether the vegetarian diet may counteract the deleterious effects of elevated AOPPs and AGEs, remains to be elucidated.
C1 Slovak Med Univ, Dept Clin & Expt Pharmacotherapy, Res Base, Bratislava 83303, Slovakia.
   Hosp Minist Def Slovak Republ, Bratislava, Slovakia.
   Hosp Univ Petrzalka, Bratislava, Slovakia.
   Comenius Univ, Fac Med, Bratislava, Slovakia.
   Univ Wurzburg, Wurzburg, Germany.
C3 Slovak Medical University Bratislava; Comenius University Bratislava;
   University of Wurzburg
RP Sebeková, K (corresponding author), Slovak Med Univ, Dept Clin & Expt Pharmacotherapy, Res Base, Limbova 12, Bratislava 83303, Slovakia.
EM katarina.sebekova@szu.sk
RI Babinská, Katarína/AAC-9817-2019; Valachovicova, Martina/AAS-1791-2020;
   Sebekova, Katarina/H-4906-2016; Boor, Peter/C-7707-2011
OI Babinska, Katarina/0000-0002-0385-025X; Valachovicova,
   Martina/0000-0003-3110-6417; Sebekova, Katarina/0000-0002-9641-9265;
   Boor, Peter/0000-0001-9921-4284
CR Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Aronson D, 2004, DIABETIC MED, V21, P39, DOI 10.1046/j.1464-5491.2003.01084.x
   Benzie IFF, 1996, ANAL BIOCHEM, V239, P70, DOI 10.1006/abio.1996.0292
   BURTON GW, 1984, SCIENCE, V224, P569, DOI 10.1126/science.6710156
   Cerhata D, 1994, Ceska Slov Farm, V43, P166
   DESANTO NG, 1995, NEPHROL DIAL TRANSPL, V10, P1629
   Faure P, 1997, J NUTR, V127, P103, DOI 10.1093/jn/127.1.103
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Fröhlich M, 2000, DIABETES CARE, V23, P1835, DOI 10.2337/diacare.23.12.1835
   Hrebícek J, 2002, J CLIN ENDOCR METAB, V87, P144, DOI 10.1210/jc.87.1.144
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Janssen-Heininger YMW, 2000, FREE RADICAL BIO MED, V28, P1317, DOI 10.1016/S0891-5849(00)00218-5
   Katz S, 2002, CAN J PLANT PATHOL, V24, P10, DOI 10.1080/07060660109506964
   KrajcovicovaKudlackova M, 1995, ANN NUTR METAB, V39, P334, DOI 10.1159/000177882
   Kuo CS, 2004, EUR J CLIN NUTR, V58, P312, DOI 10.1038/sj.ejcn.1601783
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   LEE BL, 1992, J CHROMATOGR-BIOMED, V581, P41, DOI 10.1016/0378-4347(92)80445-V
   McCarty MF, 2005, MED HYPOTHESES, V64, P394, DOI 10.1016/j.mehy.2004.03.035
   Monnier VM, 2005, ANN NY ACAD SCI, V1043, P567, DOI 10.1196/annals.1333.065
   Munch G, 1997, EUR J CLIN CHEM CLIN, V35, P669
   Nagasawa N, 2004, CIRC J, V68, P892, DOI 10.1253/circj.68.892
   PAOLISSO G, 1994, AM J CLIN NUTR, V59, P1291, DOI 10.1093/ajcn/59.6.1291
   Ridker PM, 2004, CIRCULATION, V109, P2818, DOI 10.1161/01.CIR.0000132467.45278.59
   RITZ E, 1994, NEPHROL DIAL TRANSPL, V9, P1
   Roberts CK, 2002, CIRCULATION, V106, P2530, DOI 10.1161/01.CIR.0000040584.91836.0D
   Roberts CK, 2006, J APPL PHYSIOL, V100, P1657, DOI 10.1152/japplphysiol.01292.2005
   Roebuck KA, 1999, INT J MOL MED, V4, P223
   Rutter MK, 2004, CIRCULATION, V110, P380, DOI 10.1161/01.CIR.0000136581.59584.0E
   Sandu O, 2005, DIABETES, V54, P2314, DOI 10.2337/diabetes.54.8.2314
   Sebeková K, 2001, EUR J NUTR, V40, P275, DOI 10.1007/s394-001-8356-3
   Trevisan M, 1998, AM J EPIDEMIOL, V148, P958
   Truscott TG, 1996, J PHOTOCH PHOTOBIO B, V35, P233, DOI 10.1016/S1011-1344(96)07299-5
   TSUCHIDA M, 1985, BIOCHIM BIOPHYS ACTA, V843, P214
   Unno Y, 2005, ANN NY ACAD SCI, V1043, P696, DOI 10.1196/annals.1333.080
   Uribarri J, 2005, DIABETES, V54, pA428
   Valachovicová M, 2006, EUR J NUTR, V45, P52, DOI 10.1007/s00394-005-0563-x
   Witko-Sarsat V, 2003, KIDNEY INT, V63, pS11, DOI 10.1046/j.1523-1755.63.s84.47.x
   WitkoSarsat V, 1996, KIDNEY INT, V49, P1304, DOI 10.1038/ki.1996.186
   Wittmann I., 2001, Nephrology Dialysis Transplantation, V16, pA106
NR 39
TC 52
Z9 58
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD SEP
PY 2006
VL 50
IS 9
BP 858
EP 868
DI 10.1002/mnfr.200500170
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 086SG
UT WOS:000240692700011
PM 16917805
DA 2025-06-11
ER

PT J
AU Trinei, M
   Berniakovich, I
   Beltrami, E
   Migliaccio, E
   Fassina, A
   Pelicci, P
   Giorgio, M
AF Trinei, Mirella
   Berniakovich, Ina
   Beltrami, Elena
   Migliaccio, Enrica
   Fassina, Ambrogio
   Pelicci, PierGiuseppe
   Giorgio, Marco
TI P66Shc signals to age
SO AGING-US
LA English
DT Review
DE aging; life span; degenerative disease; oxidative stress
ID VASCULAR OXIDATIVE STRESS; CORONARY-HEART-DISEASE; FREE-RADICAL THEORY;
   HIGH-FAT DIET; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; ADAPTER PROTEIN; LIFE-SPAN; ENDOTHELIAL
   DYSFUNCTION
AB Oxygen metabolism is thought to impact on aging through the formation of reactive oxygen species (ROS) that are supposed to damage biological molecules. The study of p66Shc, a crucial regulator of ROS level involved in aging dysfunction, suggests that the incidence of degenerative disease and longevity are determined by a specific signaling function of ROS other than their unspecific damaging property.
C1 [Berniakovich, Ina; Beltrami, Elena; Migliaccio, Enrica; Pelicci, PierGiuseppe; Giorgio, Marco] European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy.
   [Trinei, Mirella] Congenia Srl, I-20139 Milan, Italy.
   [Fassina, Ambrogio] Cytophatol Unit, Pathol Sect, Dept Oncol & Surg Sci, I-35100 Padua, Italy.
C3 IRCCS European Institute of Oncology (IEO); IRCCS Istituto Oncologico
   Veneto (IOV)
RP Giorgio, M (corresponding author), European Inst Oncol, Dept Expt Oncol, Via Adamello 16, I-20139 Milan, Italy.
EM Marco.giorgio@ifom-ieo-campus.it
RI Pelicci, Pier/AAL-6572-2020; beltrami, elena/AAE-9937-2021; Migliaccio,
   Enrica/AAQ-8880-2020; Giorgio, Marco/I-9425-2012
OI , Enrica Migliaccio/0000-0002-3989-8773; PELICCI, PIER
   GIUSEPPE/0000-0002-5076-2316
FU National Institute of Health [1P01AG025532-01A1]
FX We thank Paola Dalton for the preparation of the manuscript. This work
   was supported by National Institute of Health Grant 1P01AG025532-01A1.
CR Alexander CM, 2003, DIABETES, V52, P1210, DOI 10.2337/diabetes.52.5.1210
   Berniakovich I, 2008, J BIOL CHEM, V283, P34283, DOI 10.1074/jbc.M804362200
   Bianchi G, 2006, GERONTOLOGY, V52, P17, DOI 10.1159/000089821
   Blüher M, 2002, DEV CELL, V3, P25, DOI 10.1016/S1534-5807(02)00199-5
   BODKIN NL, 1995, J GERONTOL A-BIOL, V50, pB142, DOI 10.1093/gerona/50A.3.B142
   Camici GG, 2007, P NATL ACAD SCI USA, V104, P5217, DOI 10.1073/pnas.0609656104
   Diep QN, 2002, HYPERTENSION, V40, P866, DOI 10.1161/01.HYP.0000037969.41360.CC
   Francia P, 2004, CIRCULATION, V110, P2889, DOI 10.1161/01.CIR.0000147731.24444.4D
   Giorgio M, 2005, CELL, V122, P221, DOI 10.1016/j.cell.2005.05.011
   HARMAN D, 1965, J GERONTOL, V20, P151, DOI 10.1093/geronj/20.2.151
   Herrmann JM, 2000, CURR OPIN MICROBIOL, V3, P210, DOI 10.1016/S1369-5274(00)00077-1
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Khanday FA, 2006, MOL BIOL CELL, V17, P122, DOI 10.1091/mbc.e05-06-0570
   Kumashiro N, 2008, DIABETES, V57, P2083, DOI 10.2337/db08-0144
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Landmesser U, 2002, HYPERTENSION, V40, P511, DOI 10.1161/01.HYP.0000032100.23772.98
   LANFRANCONE L, 1995, ONCOGENE, V10, P907
   Lee SR, 2002, J BIOL CHEM, V277, P20336, DOI 10.1074/jbc.M111899200
   Luzi L, 2000, CURR OPIN GENET DEV, V10, P668, DOI 10.1016/S0959-437X(00)00146-5
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Masoro EJ, 1998, AGING-CLIN EXP RES, V10, P173
   Matsuzawa-Nagata N, 2008, METABOLISM, V57, P1071, DOI 10.1016/j.metabol.2008.03.010
   Menini S, 2006, DIABETES, V55, P1642, DOI 10.2337/db05-1477
   Migliaccio E, 1997, EMBO J, V16, P706, DOI 10.1093/emboj/16.4.706
   Migliaccio E, 1999, NATURE, V402, P309, DOI 10.1038/46311
   Napoli C, 2003, P NATL ACAD SCI USA, V100, P2112, DOI 10.1073/pnas.0336359100
   Natalicchio A, 2004, J BIOL CHEM, V279, P43900, DOI 10.1074/jbc.M403936200
   Nemoto S, 2002, SCIENCE, V295, P2450, DOI 10.1126/science.1069004
   Orsini F, 2004, J BIOL CHEM, V279, P25689, DOI 10.1074/jbc.M401844200
   Pacini S, 2004, MOL CELL BIOL, V24, P1747, DOI 10.1128/MCB.24.4.1747-1757.2004
   Pelicci G, 1996, ONCOGENE, V13, P633
   PELICCI G, 1992, CELL, V70, P93, DOI 10.1016/0092-8674(92)90536-L
   Pinton P, 2007, SCIENCE, V315, P659, DOI 10.1126/science.1135380
   Ravichandran KS, 2001, ONCOGENE, V20, P6322, DOI 10.1038/sj.onc.1204776
   Rota M, 2006, CIRC RES, V99, P42, DOI 10.1161/01.RES.0000231289.63468.08
   Sansone P, 2007, STEM CELLS, V25, P807, DOI 10.1634/stemcells.2006-0442
   Sanz A, 2006, ANTIOXID REDOX SIGN, V8, P582, DOI 10.1089/ars.2006.8.582
   Skalicky J, 2008, CLIN CHEM LAB MED, V46, P499, DOI 10.1515/CCLM.2008.096
   SKOLNIK EY, 1993, EMBO J, V12, P1929, DOI 10.1002/j.1460-2075.1993.tb05842.x
   Sohal RS, 1996, SCIENCE, V273, P59, DOI 10.1126/science.273.5271.59
   Taniyama Y, 2003, HYPERTENSION, V42, P1075, DOI 10.1161/01.HYP.0000100443.09293.4F
   Trinei M, 2002, ONCOGENE, V21, P3872, DOI 10.1038/sj.onc.1205513
   Wilson PWF, 2007, ARCH INTERN MED, V167, P1068, DOI 10.1001/archinte.167.10.1068
   Wilson PWF, 2005, CIRCULATION, V112, P3066, DOI 10.1161/CIRCULATIONAHA.105.539528
   Xi G, 2008, MOL ENDOCRINOL, V22, P2162, DOI 10.1210/me.2008-0079
   YOKOTE K, 1994, J BIOL CHEM, V269, P15337
   Zaccagnini G, 2004, CIRCULATION, V109, P2917, DOI 10.1161/01.CIR.0000129309.58874.0F
NR 48
TC 73
Z9 77
U1 0
U2 3
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD JUN
PY 2009
VL 1
IS 6
BP 503
EP 510
DI 10.18632/aging.100057
PG 8
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA 579UP
UT WOS:000276401300001
PM 20157533
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Bhaswant, M
   Fanning, K
   Netzel, M
   Mathai, ML
   Panchal, SK
   Brown, L
AF Bhaswant, Maharshi
   Fanning, Kent
   Netzel, Michael
   Mathai, Michael L.
   Panchal, Sunil K.
   Brown, Lindsay
TI Cyanidin 3-glucoside improves diet-induced metabolic syndrome in rats
SO PHARMACOLOGICAL RESEARCH
LA English
DT Article
DE Metabolic syndrome; Anthocyanins; Cyanidin 3-glucoside; Queen Garnet
   plum; Obesity; Inflammation
ID HIGH-CARBOHYDRATE; PROTOCATECHUIC ACID; OXIDATIVE STRESS; GUT
   MICROBIOTA; BLOOD-PRESSURE; ANTHOCYANINS; JUICE; OBESITY; RICH;
   CONSUMPTION
AB Increased consumption of dark-coloured fruits and vegetables may mitigate metabolic syndrome. This study has determined the changes in metabolic parameters, and in cardiovascular and liver structure and function, following chronic administration of either cyanidin 3-glucoside (CG) or Queen Garnet plum juice (QG) containing cyanidin glycosides to rats fed either a corn starch (C) or a high-carbohydrate, high-fat (H) diet. Eight to nine-week-old male Wistar rats were randomly divided into six groups for 16-week feeding with C, C with CG or QG, H or H with CG or QG. C or H were supplemented with CG or QG at a dose of similar to 8 mg/kg/day cyanidin glycosides from week 8 to 16. H rats developed signs of metabolic syndrome including visceral adiposity, impaired glucose tolerance, hypertension, cardiovascular remodelling, increased collagen deposition in left ventricle, non-alcoholic fatty liver disease, increased plasma liver enzymes and increased inflammatory cell infiltration in the heart and liver. Both CG and QG reversed these cardiovascular, liver and metabolic signs. However, no intact anthocyanins or common methylated/conjugated metabolites could be detected in the plasma samples and plasma hippuric acid concentrations were unchanged. Our results suggest CG is the most likely mediator of the responses to QG but that further investigation of the pharmacokinetics of oral CG in rats is required. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Bhaswant, Maharshi; Mathai, Michael L.] Victoria Univ, Coll Hlth & Biomed, Ctr Chron Dis Prevent & Management, Melbourne, Vic 8001, Australia.
   [Bhaswant, Maharshi; Brown, Lindsay] Univ So Queensland, Sch Hlth & Wellbeing, Toowoomba, Qld 4350, Australia.
   [Fanning, Kent] Dept Agr & Fisheries, Coopers Plains, Qld, Australia.
   [Netzel, Michael] Univ Queensland, Queensland Alliance Agr & Food Innovat, Ctr Nutr & Food Sci, Brisbane, Qld, Australia.
   [Panchal, Sunil K.; Brown, Lindsay] Univ So Queensland, Inst Agr & Environm, Toowoomba, Qld 4350, Australia.
C3 Victoria University; University of Southern Queensland; University of
   Queensland; University of Southern Queensland
RP Brown, L (corresponding author), Univ So Queensland, Sch Hlth & Wellbeing, Toowoomba, Qld 4350, Australia.
EM Lindsay.Brown@usq.edu.au
RI Netzel, Michael/M-4050-2013; Bhaswant, Maharshi/G-3676-2017
OI Panchal, Sunil K/0000-0001-5464-3376; , Maharshi
   Bhaswant/0000-0003-4501-5487; Mathai, Michael/0000-0001-8783-2122;
   Netzel, Michael/0000-0002-3136-3926
CR Andriantsitohaina R, 2012, BRIT J NUTR, V108, P1532, DOI 10.1017/S0007114512003406
   Anhê FF, 2015, GUT, V64, P872, DOI 10.1136/gutjnl-2014-307142
   Aura AM, 2005, EUR J NUTR, V44, P133, DOI 10.1007/s00394-004-0502-2
   Bell DR, 2006, J APPL PHYSIOL, V100, P1164, DOI 10.1152/japplphysiol.00626.2005
   Bobrich A, 2014, FOOD RES INT, V65, P20, DOI 10.1016/j.foodres.2014.06.030
   Boeing H, 2012, EUR J NUTR, V51, P637, DOI 10.1007/s00394-012-0380-y
   Boto-Ordóñez M, 2014, FOOD FUNCT, V5, P1932, DOI [10.1039/c4fo00029c, 10.1039/C4FO00029C]
   Broncel M, 2010, MED SCI MONITOR, V16, pCR28
   Brown L., 2015, OBES REV
   Chalker-Scott L, 1999, PHOTOCHEM PHOTOBIOL, V70, P1, DOI 10.1111/j.1751-1097.1999.tb01944.x
   Czank C, 2013, AM J CLIN NUTR, V97, P995, DOI 10.3945/ajcn.112.049247
   de Ferrars RM, 2014, BRIT J PHARMACOL, V171, P3268, DOI 10.1111/bph.12676
   Del Bò C, 2010, J AGR FOOD CHEM, V58, P2491, DOI 10.1021/jf903472x
   Fanning KJ, 2014, J SCI FOOD AGR, V94, P2137, DOI 10.1002/jsfa.6591
   Faria A, 2014, J AGR FOOD CHEM, V62, P6898, DOI 10.1021/jf501808a
   Felgines C, 2006, BRIT J NUTR, V95, P898, DOI 10.1079/BJN20061728
   Frank T, 2003, CAN J PHYSIOL PHARM, V81, P423, DOI [10.1139/y03-038, 10.1139/Y03-038]
   Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
   Guo HH, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-10
   Havel PJ, 2000, P NUTR SOC, V59, P359, DOI 10.1017/S0029665100000410
   Hruby A, 2015, PHARMACOECONOMICS, V33, P673, DOI 10.1007/s40273-014-0243-x
   Joseph S.V., 2015, CRIT REV FOOD SCI NU
   Kalt W, 2008, J AGR FOOD CHEM, V56, P705, DOI 10.1021/jf071998l
   Karlsen A, 2007, J NUTR, V137, P1951
   Landete JM, 2012, CRIT REV FOOD SCI, V52, P936, DOI 10.1080/10408398.2010.513779
   Li L, 2014, SCI REP-UK, V4, DOI 10.1038/srep06234
   Luo XQ, 2012, MOL CELL BIOCHEM, V362, P211, DOI 10.1007/s11010-011-1144-3
   Marseglia L, 2015, INT J MOL SCI, V16, P378, DOI 10.3390/ijms16010378
   McAllister EJ, 2009, CRIT REV FOOD SCI, V49, P868, DOI 10.1080/10408390903372599
   McKay DL, 2010, J NUTR, V140, P298, DOI 10.3945/jn.109.115097
   Netzel M, 2012, J FOOD BIOCHEM, V36, P159, DOI 10.1111/j.1745-4514.2010.00522.x
   Panchal SK, 2012, J NUTR, V142, P1026, DOI 10.3945/jn.111.157263
   Panchal SK, 2011, J NUTR, V141, P1062, DOI 10.3945/jn.111.137877
   Panchal SK, 2011, J CARDIOVASC PHARM, V57, P51, DOI [10.1097/FJC.0b013e3181feb90a, 10.1097/FJC.0b013e31821b1379]
   Pojer E, 2013, COMPR REV FOOD SCI F, V12, P483, DOI 10.1111/1541-4337.12024
   Poudyal H, 2012, J NUTR BIOCHEM, V23, P153, DOI 10.1016/j.jnutbio.2010.11.011
   Poudyal H, 2010, BRIT J NUTR, V104, P1322, DOI 10.1017/S0007114510002308
   Poudyal H, 2010, J NUTR, V140, P946, DOI 10.3945/jn.109.117812
   Prior RL, 2010, J AGR FOOD CHEM, V58, P3970, DOI 10.1021/jf902852d
   Roopchand DE, 2015, DIABETES, V64, P2847, DOI 10.2337/db14-1916
   Salamone F, 2012, WORLD J GASTROENTERO, V18, P3862, DOI 10.3748/wjg.v18.i29.3862
   Santhakumar AB, 2015, J FUNCT FOODS, V12, P11, DOI 10.1016/j.jff.2014.10.026
   Scazzocchio B, 2011, DIABETES, V60, P2234, DOI 10.2337/db10-1461
   Titta L, 2010, INT J OBESITY, V34, P578, DOI 10.1038/ijo.2009.266
   Tsuda T, 2003, J NUTR, V133, P2125, DOI 10.1093/jn/133.7.2125
   Valenti L, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/145421
   van Heerebeek L, 2009, CURR DIABETES REP, V9, P79, DOI 10.1007/s11892-009-0014-9
   Vitaglione P, 2007, J NUTR, V137, P2043, DOI 10.1093/jn/137.9.2043
   Wallace TC, 2011, ADV NUTR, V2, P1, DOI 10.3945/an.110.000042
   Wang DL, 2012, CIRC RES, V111, P967, DOI [10.1161/circresaha.112.266502, 10.1161/CIRCRESAHA.112.266502]
   Wang S, 2014, J NUTR BIOCHEM, V25, P1, DOI 10.1016/j.jnutbio.2013.09.001
   Wei XY, 2011, J SCI FOOD AGR, V91, P1006, DOI 10.1002/jsfa.4275
   Wu XL, 2006, J AGR FOOD CHEM, V54, P4069, DOI 10.1021/jf060300l
   Zamora-Ros R, 2011, BRIT J NUTR, V106, P1090, DOI 10.1017/S0007114511001437
NR 54
TC 52
Z9 56
U1 0
U2 49
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
J9 PHARMACOL RES
JI Pharmacol. Res.
PD DEC
PY 2015
VL 102
BP 208
EP 217
DI 10.1016/j.phrs.2015.10.006
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CZ0KG
UT WOS:000366793100024
PM 26477387
DA 2025-06-11
ER

PT J
AU Zuberi, AR
AF Zuberi, Aamir R.
TI Strategies for assessment of botanical action on metabolic syndrome in
   the mouse and evidence for a genotype-specific effect of Russian
   tarragon in the regulation of insulin sensitivity
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID TASTE-AVERSION; AGOUTI PROTEIN; MODIFIER GENES; MICE; OBESITY; DIET;
   HUMANS; DETERMINANTS; RESISTANCE; ADIPOSITY
AB Published reports of botanical action are often hampered by the lack of generalized systematic approaches or by the failure to explore mechanisms that could confirm and extend the reported observations. Choice of mouse or rat housing conditions (singly or group housed) and imposed stress during handling procedures are often variable and can contribute significantly to differences in baseline phenotypes measured across studies. Differences can also be observed in the role of the extract in either the treatment of the metabolic syndrome or roles in the regulation of the emergence of metabolic syndrome. The choice of diet used can also vary between the different studies, and diet-botanical interactions must be considered. This minireview highlights the strategies being pursued by the Botanical Research Center Animal Research Core to evaluate the in vivo phenotypes of several botanical extracts during long-term feeding studies. We describe a phenotyping strategy that promotes a more rigorous interpretation of botanical action and can suggest or eliminate possible mechanisms that may be involved. We discuss the importance of selecting the mouse model, as background strain can significantly alter the underlying susceptibilities to the various components of metabolic syndrome. Finally, we present data suggesting that one of the major botanical extracts being studied, an extract of Russian tarragon, may manifest a mouse strain genotype-specific insulin-sensitizing phenotype. (C) 2008 Elsevier Inc. All rights reserved.
C1 Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70810 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center
RP Zuberi, AR (corresponding author), Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70810 USA.
EM zuberia@pbrc.edu
FU NCCIH NIH HHS [P50AT002776-01, 5P50AT002776-039001, P50 AT002776]
   Funding Source: Medline; NIDDK NIH HHS [R01 DK064071, DK064071] Funding
   Source: Medline
CR Almind K, 2004, DIABETES, V53, P3274, DOI 10.2337/diabetes.53.12.3274
   Bachmanov AA, 2001, PHYSIOL BEHAV, V72, P603, DOI 10.1016/S0031-9384(01)00412-7
   Badman MK, 2007, GASTROENTEROLOGY, V132, P2103, DOI 10.1053/j.gastro.2007.03.058
   Brunner EJ, 2001, INT J OBESITY, V25, P45, DOI 10.1038/sj.ijo.0801543
   Clee Susanne M, 2005, Am J Ther, V12, P491, DOI 10.1097/01.mjt.0000178781.89789.25
   COLEMAN DL, 1984, DIABETES, V33, P26, DOI 10.2337/diabetes.33.1.26
   COLEMAN DL, 1973, DIABETOLOGIA, V9, P287, DOI 10.1007/BF01221856
   KALLMAN MJ, 1983, NEUROBEH TOXICOL TER, V5, P23
   LU DS, 1994, NATURE, V371, P799, DOI 10.1038/371799a0
   MICHAUD EJ, 1994, P NATL ACAD SCI USA, V91, P2562, DOI 10.1073/pnas.91.7.2562
   Nadeau JH, 2003, CURR OPIN GENET DEV, V13, P290, DOI 10.1016/S0959-437X(03)00061-3
   Nadeau JH, 2001, NAT REV GENET, V2, P165, DOI 10.1038/35056009
   Ollmann MM, 1998, GENE DEV, V12, P316, DOI 10.1101/gad.12.3.316
   Parker LA, 2003, LEARN BEHAV, V31, P165
   Perseghin G, 2001, ACTA DIABETOL, V38, P7, DOI 10.1007/s005920170023
   Petro AE, 2004, METABOLISM, V53, P454, DOI 10.1016/j.metabol.2003.11.018
   Qiu J, 2001, ENDOCRINOLOGY, V142, P3421, DOI 10.1210/en.142.8.3421
   Reed DR, 1997, BEHAV GENET, V27, P373, DOI 10.1023/A:1025692031673
   Ribnicky DM, 2006, PHYTOMEDICINE, V13, P550, DOI 10.1016/j.phymed.2005.09.007
   SPRINGER AD, 1981, BEHAV NEURAL BIOL, V32, P282, DOI 10.1016/S0163-1047(81)92333-5
   Stark K L, 1998, Expert Opin Investig Drugs, V7, P859, DOI 10.1517/13543784.7.6.859
   Stoehr JP, 2004, DIABETES, V53, P245, DOI 10.2337/diabetes.53.1.245
   SURWIT RS, 1988, DIABETES, V37, P1163, DOI 10.2337/diabetes.37.9.1163
   Terán-García M, 2007, APPL PHYSIOL NUTR ME, V32, P89, DOI 10.1139/h06-102
   Thigpen JE, 1999, LAB ANIM SCI, V49, P530
   TREMBLAY A, 1995, INT J OBESITY, V19, pS60
   WEST DB, 1995, AM J PHYSIOL-REG I, V268, pR658, DOI 10.1152/ajpregu.1995.268.3.R658
   WEST DB, 1992, AM J PHYSIOL, V262, pR1025, DOI 10.1152/ajpregu.1992.262.6.R1025
NR 28
TC 13
Z9 14
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUL
PY 2008
VL 57
IS 7
SU 1
BP S10
EP S15
DI 10.1016/j.metabol.2008.03.002
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 323EM
UT WOS:000257426800004
PM 18555848
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lissoni, P
   Rovelli, F
   Monzon, A
   Messina, G
   Merli, N
   Tartarelli, R
   Tassoni, S
   Zecchinato, F
   Simoes-e-Silva, AC
   Valentini, A
   Di Fede, G
   Cardinali, DP
AF Lissoni, Paolo
   Rovelli, Franco
   Monzon, Alejandra
   Messina, Giusy
   Merli, Nicoletta
   Tartarelli, Rosanna
   Tassoni, Simonetta
   Zecchinato, Francesca
   Simoes-e-Silva, Ana Cristina
   Valentini, Agnese
   Di Fede, Giuseppe
   Cardinali, Daniel P.
TI Efficacy of a Neuroimmune Therapy Including Pineal Methoxyindoles,
   Angiotensin 1-7, and Endocannabinoids in Cancer, Autoimmune, and
   Neurodegenerative Diseases
SO CLINICAL INTERVENTIONS IN AGING
LA English
DT Article
DE melatonin; 5-methoxytryptamine; metainflammation; noncommunicable
   diseases; oxytocin; pinoline
ID PSYCHOACTIVE COMPOUNDS; METABOLIC SYNDROME; BETA-CARBOLINES; MAMMALIAN
   BODY; RECEPTOR AXIS; SYSTEM; CELLS; INFLAMMATION; COMPONENTS; INHIBITORS
AB Purpose: Recent advancements in psycho-neuro-endocrine-immunology indicate that numerous noncommunicable diseases (NCDs) originate from disruptions in the cytokine immune network, resulting in chronic inflammatory responses. This persistent low-degree inflammation is attributed to deficiencies in crucial endogenous anti-inflammatory neuroendocrine systems, including the pineal gland, the endocannabinoid system, and the angiotensin-converting enzyme 2 / angiotensin 1-7 axis. The administration of pineal methoxyindoles (melatonin, 5-methoxytryptamine), cannabinoids, and angiotensin 1-7 may entail potential therapeutic benefits for NCDs, particularly for patients who do not respond to conventional treatments. Patients and Methods: This study evaluates the safety and efficacy of a neuroimmune regimen comprising melatonin (100 mg/day at night), 5-methoxytryptamine (30 mg in the early afternoon), angiotensin 1-7 (0.5 mg twice daily), and cannabidiol (20 mg twice daily) in 306 patients with NCDs, including advanced cancer, autoimmune diseases, neurodegenerative disorders, depression, and cardiovascular disease. Results: The neuroimmune regimen successfully halted cancer progression in 68% of cancer patients, who also reported improvements in mood, sleep, and relief from anxiety, pain, and fatigue. In patients with autoimmune diseases, the treatment effectively controlled the disease process, remarkable in cases of multiple sclerosis. Additionally, positive outcomes were observed in patients with Parkinson's disease, Alzheimer's disease, and depression. Conclusion: Randomized controlled trials are required to assess this therapeutic approach for NCDs that includes endogenous neuroendocrine molecules regulating immune responses in an anti-inflammatory manner.
C1 [Lissoni, Paolo; Rovelli, Franco; Monzon, Alejandra; Messina, Giusy; Merli, Nicoletta; Di Fede, Giuseppe] Int Inst PNEI, Inst Biol Med, Milan, Italy.
   [Tartarelli, Rosanna; Tassoni, Simonetta] PNEI Psychol Serv, Pietrasanta, Lucca, Italy.
   [Zecchinato, Francesca] Biotherapy Serv, Verona, Italy.
   [Simoes-e-Silva, Ana Cristina] Fac Med, Belo Horizonte, Brazil.
   [Valentini, Agnese] Madonna Soccorso Hosp, San Benedetto Tronto, Ascoli Piceno, Italy.
   [Cardinali, Daniel P.] Pontificia Univ Catolica Argentina, Fac Ciencias Med, Av Moreau de Justo 1300,C1107AFA, Buenos Aires, Argentina.
C3 Pontificia Universidad Catolica Argentina
RP Cardinali, DP (corresponding author), Pontificia Univ Catolica Argentina, Fac Ciencias Med, Av Moreau de Justo 1300,C1107AFA, Buenos Aires, Argentina.
EM cardinalidanielpedro@gmail.com
RI Di Fede, Giuseppe/K-1394-2016; Mota, Ana/JBS-4609-2023; Simoes e Silva,
   Ana Cristina/A-4409-2013
OI Simoes e Silva, Ana Cristina/0000-0001-9222-3882
CR AIRAKSINEN MM, 1981, MED BIOL, V59, P190
   AIRAKSINEN MM, 1981, MED BIOL, V59, P21
   Alenina N, 2019, NEUROCHEM RES, V44, P1323, DOI 10.1007/s11064-018-2679-4
   Amedei A, 2024, FRONT PHARMACOL, V15, DOI 10.3389/fphar.2024.1505196
   Awwad ZM, 2020, CARDIOVASC TOXICOL, V20, P301, DOI 10.1007/s12012-019-09553-6
   Bakhshimoghaddam F, 2024, J HEALTH POPUL NUTR, V43, DOI 10.1186/s41043-024-00580-w
   Barbé-Tuana F, 2020, SEMIN IMMUNOPATHOL, V42, P545, DOI 10.1007/s00281-020-00806-z
   Beurel E, 2018, BRAIN BEHAV IMMUN, V69, P28, DOI 10.1016/j.bbi.2017.08.001
   Bottaccioli AG, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23073932
   Bottaccioli AG, 2019, ANN NY ACAD SCI, V1437, P31, DOI 10.1111/nyas.13728
   Campos LA, 2013, INT J HYPERTENS, V2013, DOI 10.1155/2013/521783
   Capettini LSA, 2012, CURR PHARM DESIGN, V18, P963
   Cardinali Daniel P, 2024, Subcell Biochem, V107, P217, DOI 10.1007/978-3-031-66768-8_11
   Cardinali DP, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00480
   Chen X, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.02122
   Cruz-Sanabria F, 2024, J PINEAL RES, V76, DOI 10.1111/jpi.12985
   Du N, 2012, ONCOL REP, V27, P1893, DOI 10.3892/or.2012.1720
   Fard RM, 2024, CLIN NUTR ESPEN, V63, DOI 10.1016/j.clnesp.2024.07.015
   Franceschi C, 2018, NAT REV ENDOCRINOL, V14, P576, DOI 10.1038/s41574-018-0059-4
   Fulop T, 2023, CLIN REV ALLERG IMMU, V64, P109, DOI 10.1007/s12016-021-08899-6
   Gautam AS, 2023, N-S ARCH PHARMACOL, V396, P577, DOI 10.1007/s00210-022-02357-6
   Gheblawi M, 2020, CIRC RES, V126, P1456, DOI 10.1161/CIRCRESAHA.120.317015
   Gu LY, 2016, ONCOTARGET, V7, P31926, DOI 10.18632/oncotarget.7876
   Huang JG, 2024, FRONT IMMUNOL, V15, DOI 10.3389/fimmu.2024.1425847
   Imenshahidi M, 2024, BIOMED PHARMACOTHER, V171, DOI 10.1016/j.biopha.2024.116169
   Kannan G, 2025, INFLAMMOPHARMACOLOGY, V33, P145, DOI 10.1007/s10787-024-01635-4
   Koch M, 2015, CHRONOBIOL INT, V32, P869, DOI 10.3109/07420528.2015.1041596
   Kose N, 2019, EUR REV MED PHARMACO, V23, P2570, DOI 10.26355/eurrev_201903_17406
   Kunvariya AD, 2023, HELIYON, V9, DOI 10.1016/j.heliyon.2023.e15644
   Li JW, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25189960
   LISSONI P, 1986, HORM METAB RES, V18, P77, DOI 10.1055/s-2007-1012235
   Lissoni P, 2021, Nov Approaches Cancer Study, V5, DOI [10.31031/NACS.2021.05.000622, DOI 10.31031/NACS.2021.05.000622]
   Lissoni Paolo, 2025, Methods Mol Biol, V2868, P111, DOI 10.1007/978-1-0716-4200-9_7
   Lissoni P, 2017, EXPERT REV CLIN IMMU, V13, P491, DOI 10.1080/1744666X.2017.1245146
   Lissoni Paolo, 2012, Curr Aging Sci, V5, P231
   Luo Z, 2024, SCI PROGRESS-UK, V107, DOI 10.1177/00368504241299993
   MAESTRONI GJM, 1993, J PINEAL RES, V14, P1, DOI 10.1111/j.1600-079X.1993.tb00478.x
   Mann SJ, 2014, J CLIN HYPERTENS, V16, P6, DOI 10.1111/jch.12225
   Martinez-Ruiz L, 2023, BIOMED PHARMACOTHER, V167, DOI 10.1016/j.biopha.2023.115581
   McEwen BS, 2020, J NEUROSCI, V40, P12, DOI 10.1523/JNEUROSCI.0733-19.2019
   McQuaid RJ, 2014, NEUROSCI BIOBEHAV R, V45, P305, DOI 10.1016/j.neubiorev.2014.07.005
   Méndez N, 2023, J PINEAL RES, V75, DOI 10.1111/jpi.12908
   Minczuk K, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23116350
   Miranda-Riestra A, 2024, MOL PHARMACOL, V106, P107, DOI 10.1124/molpharm.124.000890
   Moazen S, 2024, CURR MOL PHARMACOL, V17, DOI 10.2174/0118761429315431240712100124
   Mompeón A, 2016, MOL CELL ENDOCRINOL, V422, P1, DOI 10.1016/j.mce.2015.11.004
   Munn LL, 2017, WIRES SYST BIOL MED, V9, DOI 10.1002/wsbm.1370
   Muzammil K, 2024, PROSTAG OTH LIPID M, V175, DOI 10.1016/j.prostaglandins.2024.106887
   Nunes-Souza V, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25179515
   Parolini C, 2024, MAR DRUGS, V22, DOI 10.3390/md22010017
   Platten M, 2009, P NATL ACAD SCI USA, V106, P14948, DOI 10.1073/pnas.0903958106
   Rafiyian M, 2024, FUNCT INTEGR GENOMIC, V24, DOI 10.1007/s10142-024-01454-4
   Reiter RJ, 2024, INT J ONCOL, V65, DOI 10.3892/ijo.2024.5702
   Prestes TRR, 2017, CURR DRUG TARGETS, V18, P1301, DOI 10.2174/1389450117666160727142401
   Rosenthal T, 2019, ANTICANCER RES, V39, P4597, DOI 10.21873/anticanres.13639
   Shalata W, 2024, CANCERS, V16, DOI 10.3390/cancers16162909
   Shukla AK, 2024, WORLD J DIABETES, V15, DOI 10.4239/wjd.v15.i4.606
   Shukla AK, 2021, HIGH BLOOD PRESS CAR, V28, P129, DOI 10.1007/s40292-021-00439-9
   Silva ACSE, 2013, BRIT J PHARMACOL, V169, P477, DOI 10.1111/bph.12159
   Santos RAS, 2018, PHYSIOL REV, V98, P505, DOI 10.1152/physrev.00023.2016
   Tan D.-X., 2019, MELATONIN RES, V2, P44, DOI [DOI 10.32794/MR11250011, 10.32794/mr11250011]
   TAPP E, 1980, J NEURAL TRANSM, V48, P119, DOI 10.1007/BF01250040
   Thakur T, 2024, INDIAN J PSYCHIAT, V66, P457, DOI 10.4103/indianjpsychiatry.indianjpsychiatry_965_23
   Thimm C, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25179332
   Tredicine M, 2025, FEBS LETT, V599, P927, DOI 10.1002/1873-3468.70013
   Tshikhudo PP, 2024, CHEM BIODIVERS, V21, DOI 10.1002/cbdv.202301263
   Vigano M, 2025, FRONT IMMUNOL, V16, DOI 10.3389/fimmu.2025.1497829
   World Health Organization, AGEING HLTH
   World Health Organization, Noncommunicable diseases-SEARO 2020
   World Health Organization, WHO Classification of Tumours: Breast Tumours, V5th
   Xia SJ, 2016, J IMMUNOL RES, V2016, DOI 10.1155/2016/8426874
   Ye XC, 2024, BMJ OPEN, V14, DOI 10.1136/bmjopen-2024-087841
   Yi Q, 2021, PUBLIC HEALTH NUTR, V24, P5463, DOI 10.1017/S1368980021000288
   Zhang YQ, 2025, CURR VASC PHARMACOL, V23, P136, DOI 10.2174/0115701611328810241028112700
   Zheng J, 2024, CELL SIGNAL, V124, DOI 10.1016/j.cellsig.2024.111413
NR 75
TC 0
Z9 0
U1 0
U2 0
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-1998
J9 CLIN INTERV AGING
JI Clin. Interv. Aging
PY 2025
VL 20
BP 513
EP 522
DI 10.2147/CIA.S513910
PG 10
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 2ED6U
UT WOS:001480502400001
PM 40330271
DA 2025-06-11
ER

PT J
AU Vincent, AM
   Hinder, LM
   Pop-Busui, R
   Feldman, EL
AF Vincent, Andrea M.
   Hinder, Lucy M.
   Pop-Busui, Rodica
   Feldman, Eva L.
TI Hyperlipidemia: a new therapeutic target for diabetic neuropathy
SO JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
LA English
DT Review
DE low-density lipoprotein; mitochondria; NAD(P)H oxidase; oxLDL;
   triglycerides
ID LOW-DENSITY-LIPOPROTEIN; PROGRAMMED CELL-DEATH; INDUCED OXIDATIVE
   STRESS; HUMAN ENDOTHELIAL-CELLS; OXIDIZED LDL; METABOLIC SYNDROME;
   VASCULAR COMPLICATIONS; NEUROVASCULAR FUNCTION; PERIPHERAL NEUROPATHY;
   LOX-1 EXPRESSION
AB Emerging data establish dyslipidemia as a significant contributor to the development of diabetic neuropathy. In this review, we discuss how separate metabolic imbalances, including hyperglycemia and hyperlipidemia, converge on mechanisms leading to oxidative stress in dorsal root ganglia (DRG) sensory neurons. We conclude with suggestions for novel therapeutic strategies to prevent or reverse diabetes-induced nerve degeneration.
C1 [Vincent, Andrea M.; Hinder, Lucy M.; Feldman, Eva L.] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA.
   [Pop-Busui, Rodica] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan
RP Vincent, AM (corresponding author), Univ Michigan, Dept Neurol, 5017 BSRB,109 Zina Pitcher Pl, Ann Arbor, MI 48109 USA.
EM andreav@umich.edu
OI Pop-Busui, Rodica/0000-0002-2042-1350; Hinder, Lucy/0000-0002-5206-8010;
   Feldman, Eva/0000-0002-9162-2694
FU Juvenile Diabetes Research Foundation; American Diabetes Association;
   Animal Models of Diabetes Complications Consortium [UO1 DK076160];
   Program for Neurology Research and Discovery; A. Alfred Taubman Medical
   Institute
FX The Feldman Laboratory is supported by the Juvenile Diabetes Research
   Foundation (A. M. V., E. L. F., R. P. B.), the American Diabetes
   Association (A. M. V., E. L. F., R. P. B.), the Animal Models of
   Diabetes Complications Consortium (NIH UO1 DK076160, E. L. F.), the
   Program for Neurology Research and Discovery, and the A. Alfred Taubman
   Medical Institute.
CR Aasum E, 2008, J MOL CELL CARDIOL, V44, P201, DOI 10.1016/j.yjmcc.2007.08.020
   Algire C, 2008, ENDOCR-RELAT CANCER, V15, P833, DOI 10.1677/ERC-08-0038
   Azad N, 1999, J DIABETES COMPLICAT, V13, P307, DOI 10.1016/S1056-8727(99)00062-8
   Bäumer AT, 2008, J BIOL CHEM, V283, P7864, DOI 10.1074/jbc.M704997200
   Barrett AM, 2007, PAIN MED, V8, pS50, DOI 10.1111/j.1526-4637.2006.00179.x
   Berkplanken I, 2001, DIABETES CARE, V24, P1335
   Bonora E, 2006, ANN MED, V38, P64, DOI 10.1080/07853890500401234
   Brownlee M, 2005, DIABETES, V54, P1615, DOI 10.2337/diabetes.54.6.1615
   Calkin AC, 2007, CURR PHARM DESIGN, V13, P2736, DOI 10.2174/138161207781662902
   Cameron N, 2003, DIABETES RES CLIN PR, V61, pS35, DOI 10.1016/S0168-8227(03)00123-2
   Ceriello Antonio, 2006, Endocr Pract, V12 Suppl 1, P60
   Chen JW, 2006, BIOCHEM J, V393, P255, DOI 10.1042/BJ20050845
   Clemens A, 2004, EXP CLIN ENDOCR DIAB, V112, P493, DOI 10.1055/s-2004-821306
   Cotter MA, 2003, LIFE SCI, V73, P1813, DOI 10.1016/S0024-3205(03)00508-3
   Dandapat A, 2007, ARTERIOSCL THROM VAS, V27, P2435, DOI 10.1161/ATVBAHA.107.152272
   Davis TME, 2008, DIABETOLOGIA, V51, P562, DOI 10.1007/s00125-007-0919-2
   Deplanque D, 2003, J NEUROSCI, V23, P6264
   Dimmeler S, 1997, CIRCULATION, V95, P1760
   Dominguez JH, 2008, AM J PHYSIOL-RENAL, V294, pF110, DOI 10.1152/ajprenal.00013.2007
   Draczynska-Lusiak B, 1998, NEUROREPORT, V9, P527, DOI 10.1097/00001756-199802160-00028
   Draczynska-Lusiak B, 1998, MOL CHEM NEUROPATHOL, V33, P139, DOI 10.1007/BF02870187
   Draude G, 1999, BIOCHEM PHARMACOL, V57, P383, DOI 10.1016/S0006-2952(98)00313-X
   Edwards JL, 2008, PHARMACOL THERAPEUT, V120, P1, DOI 10.1016/j.pharmthera.2008.05.005
   EDWARDS JL, 2009, DIABETOLOGIA    1022
   Feldman E. L., 2002, CONT ENDOCRINOLOGY, P437
   Feldman EL, 1997, CLIN NEUROSCI, V4, P365
   *FIELD STUD, 2007, CARDIOVASC J S AFR, V18, P400
   Figueroa-Romero C, 2008, REV ENDOCR METAB DIS, V9, P301, DOI 10.1007/s11154-008-9104-2
   Firth J, 2008, LANCET, V371, P722, DOI 10.1016/S0140-6736(08)60334-7
   Fonseca Vivian A, 2005, Clin Cornerstone, V7, P61, DOI 10.1016/S1098-3597(05)80069-9
   Genuth S, 1999, DIABETES CARE, V22, P99
   Genuth Saul, 2006, Endocr Pract, V12 Suppl 1, P34
   Giugliano D, 2008, AM J CLIN NUTR, V87, p217S, DOI 10.1093/ajcn/87.1.217S
   Greene DA, 1999, EUR J PHARMACOL, V375, P217, DOI 10.1016/S0014-2999(99)00356-8
   Grundy Scott M, 2005, Clin Cornerstone, V7, P36, DOI 10.1016/S1098-3597(05)80066-3
   HAMMER A, 1995, ARTERIOSCL THROM VAS, V15, P704, DOI 10.1161/01.ATV.15.5.704
   Harano Y, 2006, LIVER INT, V26, P613, DOI 10.1111/j.1478-3231.2006.01265.x
   HEINECKE JW, 1987, FREE RADICAL BIO MED, V3, P65, DOI 10.1016/0891-5849(87)90040-2
   Herz J, 2002, ANNU REV BIOCHEM, V71, P405, DOI 10.1146/annurev.biochem.71.110601.135342
   Higashi Y, 2005, J LIPID RES, V46, P1266, DOI 10.1194/jlr.M400478-JLR200
   Hu B, 2003, BIOCHEM BIOPH RES CO, V307, P1008, DOI 10.1016/S0006-291X(03)01295-6
   Isomaa B, 2001, DIABETOLOGIA, V44, P1148, DOI 10.1007/s001250100615
   Iwashima Y, 2000, BIOCHEM BIOPH RES CO, V277, P368, DOI 10.1006/bbrc.2000.3685
   Keech AC, 2007, LANCET, V370, P1687, DOI 10.1016/S0140-6736(07)61607-9
   Keller JN, 2000, EXP NEUROL, V161, P621, DOI 10.1006/exnr.1999.7276
   Keller JN, 1999, EXP NEUROL, V157, P202, DOI 10.1006/exnr.1999.7043
   Kelly KJ, 2008, AM J PHYSIOL-RENAL, V294, pF1136, DOI 10.1152/ajprenal.00396.2007
   Kempler P, 2002, DIABETIC MED, V19, P900, DOI 10.1046/j.1464-5491.2002.00821.x
   Kles KA, 2006, CURR DIABETES REV, V2, P131, DOI 10.2174/157339906776818569
   Kooistra T, 2006, ARTERIOSCL THROM VAS, V26, P2322, DOI 10.1161/01.ATV.0000238348.05028.14
   Krentz AJ, 2003, DIABETES OBES METAB, V5, pS19, DOI 10.1046/j.1462-8902.2003.0310.x
   Leiter LA, 2005, DIABETES RES CLIN PR, V68, pS3, DOI 10.1016/j.diabres.2005.03.015
   Li DY, 2005, CARDIOVASC RES, V68, P353, DOI 10.1016/j.cardiores.2005.09.009
   Li L, 2004, CIRC RES, V94, P892, DOI 10.1161/01.RES.0000124920.09738.26
   Li L, 2003, DIABETES, V52, P1843, DOI 10.2337/diabetes.52.7.1843
   Lie J, 2005, BBA-MOL CELL BIOL L, V1738, P48, DOI 10.1016/j.bbalip.2005.10.002
   Low PA, 1997, DIABETES, V46, pS38, DOI 10.2337/diab.46.2.S38
   Lyons TJ, 2004, INVEST OPHTH VIS SCI, V45, P910, DOI 10.1167/iovs.02-0648
   Martin CL, 2006, DIABETES CARE, V29, P340, DOI 10.2337/diacare.29.02.06.dc05-1549
   MCMANIS PG, 1994, NEUROLOGY, V44, P2185, DOI 10.1212/WNL.44.11.2185
   Murdoch CE, 2006, CURR OPIN PHARMACOL, V6, P148, DOI 10.1016/j.coph.2005.10.008
   Napoli C, 2003, ANN NY ACAD SCI, V1010, P698, DOI 10.1196/annals.1299.127
   Osawa T, 2005, ANN NY ACAD SCI, V1043, P440, DOI 10.1196/annals.1333.050
   Papassotiropoulos A, 1996, NEUROSCI LETT, V209, P33, DOI 10.1016/0304-3940(96)12595-7
   Papassotiropoulos A, 2005, J CLIN PSYCHIAT, V66, P940, DOI 10.4088/JCP.v66n0720
   Park CW, 2006, KIDNEY INT, V69, P1511, DOI 10.1038/sj.ki.5000209
   Pennathur Subramaniam, 2007, Curr Diab Rep, V7, P257, DOI 10.1007/s11892-007-0041-3
   Pop-Busui R, 2009, CIRCULATION, V119, P2886, DOI 10.1161/CIRCULATIONAHA.108.837369
   Rudijanto Achmad, 2007, Acta Med Indones, V39, P36
   Russell JW, 2008, NEUROBIOL DIS, V30, P420, DOI 10.1016/j.nbd.2008.02.013
   Russell JW, 1998, ANN NEUROL, V44, P439
   Russell JW, 1999, NEUROBIOL DIS, V6, P347, DOI 10.1006/nbdi.1999.0254
   Russell JW, 2001, NEUROLOGY, V56, pA394
   Saenz A, 2005, COCHRANE DB SYST REV, V3
   Schalkwijk CG, 2005, CLIN SCI, V109, P143, DOI 10.1042/CS20050025
   Schroeter H, 2000, FREE RADICAL BIO MED, V29, P1222, DOI 10.1016/S0891-5849(00)00415-9
   Shamir R, 2008, PEDIATR DIABETES, V9, P104, DOI 10.1111/j.1399-5448.2007.00313.x
   SHAMOON H, 1993, NEW ENGL J MED, V329, P977, DOI 10.1056/NEJM199307293290502
   Silver AE, 2007, CIRCULATION, V115, P627, DOI 10.1161/CIRCULATIONAHA.106.657486
   Simó R, 2007, LANCET, V370, P1667, DOI 10.1016/S0140-6736(07)61608-0
   Smith AG, 2006, J NEUROL SCI, V242, P9, DOI 10.1016/j.jns.2005.11.020
   Srivastava RAK, 2006, MOL CELL BIOCHEM, V285, P35, DOI 10.1007/s11010-005-9053-y
   Stamler JS, 1996, NATURE, V380, P108
   Sullivan KA, 2005, CURR OPIN NEUROL, V18, P586, DOI 10.1097/01.wco.0000178825.56414.52
   Tesfaye S, 2005, NEW ENGL J MED, V352, P341, DOI 10.1056/NEJMoa032782
   Tesfaye S, 2007, CLIN MED, V7, P113, DOI 10.7861/clinmedicine.7-2-113
   Thum T, 2008, J BIOL CHEM, V283, P19456, DOI 10.1074/jbc.M708309200
   Tomlinson DR, 2008, NAT REV NEUROSCI, V9, P36, DOI 10.1038/nrn2294
   Tsimikas S, 2005, NEW ENGL J MED, V353, P46, DOI 10.1056/NEJMoa043175
   Tsuzura S, 2004, METABOLISM, V53, P297, DOI 10.1016/j.metabol.2003.10.009
   Turner RC, 1998, LANCET, V352, P837, DOI 10.1016/s0140-6736(98)07019-6
   Ueno T, 2003, HYPERTENS RES, V26, P117
   Vincent AM, 2005, ANTIOXID REDOX SIGN, V7, P1494, DOI 10.1089/ars.2005.7.1494
   Vincent AM, 2005, FASEB J, V19, P638, DOI 10.1096/fj.04-2513fje
   Vincent AM, 2004, ENDOCR REV, V25, P612, DOI 10.1210/er.2003-0019
   Vincent AM, 2004, REV ENDOCR METAB DIS, V5, P227, DOI 10.1023/B:REMD.0000032411.11422.e0
   Vincent AM, 2004, DIABETES, V53, P726, DOI 10.2337/diabetes.53.3.726
   Vincent AM, 2008, CURR DRUG TARGETS, V9, P94, DOI 10.2174/138945008783431754
   Vincent AM, 2008, ANTIOXID REDOX SIGN, V10, P387, DOI 10.1089/ars.2007.1815
   Vincent AM, 2007, EXP NEUROL, V208, P216, DOI 10.1016/j.expneurol.2007.07.017
   Vincent AM, 2007, ENDOCRINOLOGY, V148, P548, DOI 10.1210/en.2006-0073
   Vincent AM, 2009, DIABETES, V58, P2376, DOI 10.2337/db09-0047
   Vindis C, 2005, ARTERIOSCL THROM VAS, V25, P639, DOI 10.1161/01.ATV.0000154359.60886.33
   Wiggin TD, 2008, ENDOCRINOLOGY, V149, P4928, DOI 10.1210/en.2008-0869
   Wiggin TD, 2009, DIABETES, V58, P1634, DOI 10.2337/db08-1771
   Willems D, 1998, ATHEROSCLEROSIS, V137, pS61, DOI 10.1016/S0021-9150(97)00320-1
   Xie WD, 2007, PHARMACOL RES, V55, P392, DOI 10.1016/j.phrs.2007.01.014
   Yamashita S, 2007, MOL CELL BIOCHEM, V299, P19, DOI 10.1007/s11010-005-9031-4
   Yoon SH, 2007, BIOL PHARM BULL, V30, P2196, DOI 10.1248/bpb.30.2196
   YOUNG MJ, 1993, DIABETOLOGIA, V36, P150, DOI 10.1007/BF00400697
   Ziegler D, 2004, DIABETES CARE, V27, P2178, DOI 10.2337/diacare.27.9.2178
   Ziegler D, 2006, DIABETES CARE, V29, P2365, DOI 10.2337/dc06-1216
   Zimmet P, 2008, NAT CLIN PRACT ENDOC, V4, P239, DOI 10.1038/ncpendmet0834
NR 113
TC 125
Z9 134
U1 3
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1085-9489
EI 1529-8027
J9 J PERIPHER NERV SYST
JI J. Peripher. Nerv. Syst.
PD DEC
PY 2009
VL 14
IS 4
BP 257
EP 267
DI 10.1111/j.1529-8027.2009.00237.x
PG 11
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 533ZT
UT WOS:000272865900001
PM 20021567
OA Green Published, Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Castillo-García, EL
   Cossio-Ramírez, AL
   Córdoba-Méndez, OA
   Loza-Mejía, MA
   Salazar, JR
   Chávez-Gutiérrez, E
   Bautista-Poblet, G
   Castillo-Mendieta, NT
   Moreno, DA
   García-Viguera, C
   Pinto-Almazán, R
   Almanza-Pérez, JC
   Gallardo, JM
   Guerra-Araiza, C
AF Castillo-Garcia, Emily Leonela
   Cossio-Ramirez, Ana Lizzet
   Cordoba-Mendez, Oscar Arturo
   Loza-Mejia, Marco A.
   Salazar, Juan Rodrigo
   Chavez-Gutierrez, Edwin
   Bautista-Poblet, Guadalupe
   Castillo-Mendieta, Nadia Tzayaka
   Moreno, Diego A.
   Garcia-Viguera, Cristina
   Pinto-Almazan, Rodolfo
   Almanza-Perez, Julio Cesar
   Gallardo, Juan Manuel
   Guerra-Araiza, Christian
TI In Silico and In Vivo Evaluation of the Maqui Berry (Aristotelia
   chilensis (Mol.) Stuntz) on Biochemical Parameters and Oxidative
   Stress Markers in a Metabolic Syndrome Model
SO METABOLITES
LA English
DT Article
DE metabolic syndrome; maqui berry; molecular docking; diet-induced model;
   oxidative stress
ID MOLECULAR DOCKING; ANTHOCYANINS; LIGAND; SIMULATIONS; CYANIDIN; BINDING;
   VITRO; RICH
AB Metabolic syndrome (MetS) is a complex disease that includes metabolic and physiological alterations in various organs such as the heart, pancreas, liver, and brain. Reports indicate that blackberry consumption, such as maqui berry, has a beneficial effect on chronic diseases such as cardiovascular disease, obesity, and diabetes. In the present study, in vivo and in silico studies have been performed to evaluate the molecular mechanisms implied to improve the metabolic parameters of MetS. Fourteen-day administration of maqui berry reduces weight gain, blood fasting glucose, total blood cholesterol, triacylglycerides, insulin resistance, and blood pressure impairment in the diet-induced MetS model in male and female rats. In addition, in the serum of male and female rats, the administration of maqui berry (MB) improved the concentration of MDA, the activity of SOD, and the formation of carbonyls in the group subjected to the diet-induced MetS model. In silico studies revealed that delphinidin and its glycosylated derivatives could be ligands of some metabolic targets such as alpha-glucosidase, PPAR-alpha, and PPAR-gamma, which are related to MetS parameters. The experimental results obtained in the study suggest that even at low systemic concentrations, anthocyanin glycosides and aglycones could simultaneously act on different targets related to MetS. Therefore, these molecules could be used as coadjuvants in pharmacological interventions or as templates for designing new multitarget molecules to manage patients with MetS.
C1 [Castillo-Garcia, Emily Leonela; Bautista-Poblet, Guadalupe; Guerra-Araiza, Christian] Hosp Especialidades Dr Bernardo Sepulveda, Ctr Med Nacl Siglo 21, Inst Mexicano Seguro Social, Unidad Invest Med Farmacol, Mexico City 06720, Mexico.
   [Castillo-Garcia, Emily Leonela; Bautista-Poblet, Guadalupe] Univ Autonoma Metropolitana, Doctorado Ciencias Biol & Salud, Mexico City 52919, Mexico.
   [Cossio-Ramirez, Ana Lizzet] Escuela Super Med, Inst Politecn Nacl, Secc Estudios Posgrad & Invest, Maestria Ciencias Salud, Mexico City 11340, Mexico.
   [Cordoba-Mendez, Oscar Arturo; Loza-Mejia, Marco A.; Salazar, Juan Rodrigo] Univ La Salle Mexico, Chem Sci Sch, Design Isolat & Synth Bioact Mol Res Grp, Benjamin Franklin 45, Mexico City 06140, Mexico.
   [Chavez-Gutierrez, Edwin] Escuela Nacl Ciencias Biol, Inst Politecn Nacl, Doctorado Ciencias Biomed & Biotecnol Mol, Prolongacion Manuel Carpio & Plan Ayala S-N, Mexico City 11340, Mexico.
   [Castillo-Mendieta, Nadia Tzayaka] Hosp Especialidades Ctr Med La Raza, Inst Mexicano Seguro Social, Ctr Med Nacl Siglo 21, Postdoctorate Conacyt Unidad Invest Med Enfermedad, Av Cuauhtemoc 330 Col Doctores, Mexico City 06725, Mexico.
   [Moreno, Diego A.; Garcia-Viguera, Cristina] CSIC, Lab Fitoquim & Alimentos Saludables LabFAS, CEBAS, Campus Univ Espinardo 25, E-30100 Murcia, Spain.
   [Pinto-Almazan, Rodolfo] Escuela Super Med, Inst Politecn Nacl, Secc Estudios Posgrad & Invest, Mexico City 11340, Mexico.
   [Almanza-Perez, Julio Cesar] UAM I, Dept Ciencias Salud, Lab Farmacol, DCBS, Mexico City 09310, Mexico.
   [Gallardo, Juan Manuel] Hosp Especialidades Ctr Med La Raza, Ctr Med Nacl Siglo 21, Unidad Invest Med Enfermedades Nefrol, Inst Mexicano Seguro Social, Mexico City 06720, Mexico.
C3 Instituto Mexicano del Seguro Social; Universidad Autonoma Metropolitana
   - Mexico; Instituto Politecnico Nacional - Mexico; Instituto Politecnico
   Nacional - Mexico; Instituto Mexicano del Seguro Social; Consejo
   Superior de Investigaciones Cientificas (CSIC); CSIC - Centro de
   Edafologia y Biologia Aplicada del Segura (CEBAS); Instituto Politecnico
   Nacional - Mexico; Universidad Autonoma Metropolitana - Mexico;
   Instituto Mexicano del Seguro Social
RP Guerra-Araiza, C (corresponding author), Hosp Especialidades Dr Bernardo Sepulveda, Ctr Med Nacl Siglo 21, Inst Mexicano Seguro Social, Unidad Invest Med Farmacol, Mexico City 06720, Mexico.; Pinto-Almazán, R (corresponding author), Escuela Super Med, Inst Politecn Nacl, Secc Estudios Posgrad & Invest, Mexico City 11340, Mexico.
EM cbs2202800924@tlitani.uam.mx; acossior2100@alumno.ipn.mx;
   oc@lasallistas.org.mx; marcoantonio.loza@lasalle.mx;
   juan.salazar@lasalle.mx; echavezg1700@alumno.ipn.mx;
   cbs2221801021@xanum.uam.mx; tzayakita@gmail.com; dmoreno@cebas.csic.es;
   cgviguera@cebas.csic.es; rodolfopintoalmazan@gmail.com;
   jcap@xanum.uam.mx; jmgallardom@gmail.com; christianguerra2001@gmail.com
RI Chávez Gutiérrez, Edwin/KCY-3394-2024; GALLARDO, Juan/HGF-1360-2022;
   Salazar, Juan/AFQ-6683-2022; GARCIA-VIGUERA, CRISTINA/AAH-2013-2021;
   GARCIA-VIGUERA, CRISTINA/B-2153-2012; Pinto-Almazan,
   Rodolfo/F-3483-2013; Moreno-Fernandez, Diego Angel/G-4379-2011;
   Loza-Mejia, Marco A./F-3557-2019
OI GARCIA-VIGUERA, CRISTINA/0000-0002-4751-3917; Pinto-Almazan,
   Rodolfo/0000-0002-5210-5395; GALLARDO, Juan Manuel/0000-0001-8833-4651;
   Chavez Gutierrez, Edwin/0000-0002-8571-4111; Moreno-Fernandez, Diego
   Angel/0000-0002-6547-8764; Loza-Mejia, Marco A./0000-0002-8449-0806;
   Almanza-Perez, Julio/0000-0002-9417-5500
FU CONACyT [785220]
FX This work was submitted in partial fulfillment of the requirements for
   the Ph.D. degree of Emily Leonela Castillo Garcia at Doctorado en
   Ciencias Biologicas y de la Salud (UAM-I). Emily Leonela Castillo Garcia
   received financial support from CONACyT (785220).
CR Ali MA, 2020, J KING SAUD UNIV SCI, V32, P891, DOI 10.1016/j.jksus.2019.05.004
   Alvarado J, 2016, PANMINERVA MED, V58
   Alvarado JL, 2016, BIOMED RES INT, V2016, DOI 10.1155/2016/9070537
   Araos J.P., 2015, Med. Chem, V5, P378, DOI [10.4172/2161-0444.1000289, DOI 10.4172/2161-0444.1000289]
   Berman HM, 2000, NUCLEIC ACIDS RES, V28, P235, DOI 10.1093/nar/28.1.235
   Bird Stephen R, 2016, BMJ Open Sport Exerc Med, V2, pe000143, DOI 10.1136/bmjsem-2016-000143
   Brauch JE, 2016, FOOD CHEM, V190, P308, DOI 10.1016/j.foodchem.2015.05.097
   Bribiesca-Cruz I, 2021, NUTR NEUROSCI, V24, P477, DOI 10.1080/1028415X.2019.1645438
   Chávez-Gutiérrez E, 2022, PHARMACEUTICALS-BASE, V15, DOI 10.3390/ph15121461
   Chen JG, 2020, INT J BIOL MACROMOL, V143, P696, DOI 10.1016/j.ijbiomac.2019.09.091
   Chinnasamy S, 2020, J BIOMOL STRUCT DYN, V38, P4325, DOI 10.1080/07391102.2019.1674695
   Daveri E, 2018, REDOX BIOL, V18, P16, DOI 10.1016/j.redox.2018.05.012
   Duan Y, 2003, J COMPUT CHEM, V24, P1999, DOI 10.1002/jcc.10349
   Escribano-Bailón MT, 2006, PHYTOCHEM ANALYSIS, V17, P8, DOI 10.1002/pca.872
   Espinosa-García C, 2020, EUR J NEUROSCI, V52, P2724, DOI 10.1111/ejn.14751
   Estévez M, 2019, REDOX BIOL, V26, DOI 10.1016/j.redox.2019.101277
   Fang J, 2014, DRUG METAB REV, V46, P508, DOI 10.3109/03602532.2014.978080
   Ferrero E, 2017, J TRANSL MED, V15, DOI 10.1186/s12967-017-1285-6
   Gao FY, 2020, J AGR FOOD CHEM, V68, P12141, DOI 10.1021/acs.jafc.0c04974
   Gironés-Vilaplana A, 2014, J FUNCT FOODS, V7, P599, DOI 10.1016/j.jff.2013.12.025
   González-Alvarez H, 2021, PHARMACEUTICALS-BASE, V14, DOI 10.3390/ph14090914
   Hamulic D, 2019, J NAT PROD, V82, P823, DOI 10.1021/acs.jnatprod.8b00884
   Hernández-Rodríguez M, 2016, CURR MED CHEM, V23, P3909, DOI 10.2174/0929867323666160530144742
   Hidalgo J, 2014, Panminerva Med, V56, P1
   Jia YY, 2013, BBA-MOL CELL BIOL L, V1831, P698, DOI 10.1016/j.bbalip.2012.11.012
   Kersten S, 2014, MOL METAB, V3, P354, DOI 10.1016/j.molmet.2014.02.002
   Krieger E, 2015, J COMPUT CHEM, V36, P996, DOI 10.1002/jcc.23899
   Lazim R, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21176339
   LEVINE RL, 1994, METHOD ENZYMOL, V233, P346
   Loza-Mejía MA, 2015, J MOL GRAPH MODEL, V62, P18, DOI 10.1016/j.jmgm.2015.08.010
   Masoodi H, 2019, FOOD FUNCT, V10, P3057, DOI [10.1039/C8FO02429D, 10.1039/c8fo02429d]
   Miranda-Rottmann S, 2002, J AGR FOOD CHEM, V50, P7542, DOI 10.1021/jf025797n
   Naseri R, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01310
   Ojeda D, 2010, J ETHNOPHARMACOL, V127, P7, DOI 10.1016/j.jep.2009.09.059
   Espinosa-Valdés MP, 2019, MOLECULES, V24, DOI 10.3390/molecules24020327
   Park M, 2023, BRIEF BIOINFORM, V24, DOI 10.1093/bib/bbad344
   Rahaman MM, 2023, FOOD SCI NUTR, V11, P1657, DOI 10.1002/fsn3.3217
   Rani J, 2022, J BIOMOL STRUCT DYN, V40, P12118, DOI 10.1080/07391102.2021.1968497
   Rojo LE, 2012, FOOD CHEM, V131, P387, DOI 10.1016/j.foodchem.2011.08.066
   Roman R, 2023, PROCESSES, V11, DOI 10.3390/pr11020479
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sandoval V, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8090360
   Santos LHS, 2019, METHODS MOL BIOL, V2053, P13, DOI 10.1007/978-1-4939-9752-7_2
   Silva M, 1997, BOL SOC CHIL QUIM, V42, P39
   Tajiani F, 2023, BMC CHEM, V17, DOI 10.1186/s13065-023-00999-y
   Thomsen R, 2006, J MED CHEM, V49, P3315, DOI 10.1021/jm051197e
   Tian JL, 2019, J AGR FOOD CHEM, V67, P13624, DOI 10.1021/acs.jafc.9b06155
   UCHIYAMA M, 1978, ANAL BIOCHEM, V86, P271, DOI 10.1016/0003-2697(78)90342-1
   Vendrame S, 2016, ANTIOXIDANTS-BASEL, V5, DOI 10.3390/antiox5040034
   Vidal-Ostos F, 2022, EUR J CLIN INVEST, V52, DOI 10.1111/eci.13674
   Wang DD, 2020, COMPUT STRUCT BIOTEC, V18, P439, DOI 10.1016/j.csbj.2020.02.007
   Watson RR, 2015, MINERVA CARDIOANGIOL, V63, P1
   Xiao T, 2017, J AGR FOOD CHEM, V65, P6211, DOI 10.1021/acs.jafc.7b02550
   Zhang Q, 2018, DIABETES RES CLIN PR, V142, P363, DOI 10.1016/j.diabres.2018.06.017
NR 54
TC 2
Z9 2
U1 0
U2 7
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD DEC
PY 2023
VL 13
IS 12
AR 1189
DI 10.3390/metabo13121189
PG 16
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DL0T5
UT WOS:001132087800001
PM 38132871
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dyball, D
   Evans, S
   Boos, CJ
   Steyelink, SAM
   Fear, NT
AF Dyball, Daniel
   Evans, Sarah
   Boos, Christopher J.
   Steyelink, Sharon A. M.
   Fear, Nicola T.
TI The association between PTSD and cardiovascular disease and its risk
   factors in male veterans of the Iraq/Afghanistan conflicts: a systematic
   review
SO INTERNATIONAL REVIEW OF PSYCHIATRY
LA English
DT Review
DE Afghanistan; cardiovascular diseases; Iraq; military personnel; stress
   disorder; post-traumatic
ID POSTTRAUMATIC-STRESS-DISORDER; HEART-RATE-VARIABILITY; COMBAT-RELATED
   PTSD; BLOOD-PRESSURE; METABOLIC SYNDROME; INFLAMMATORY MARKERS;
   INSULIN-RESISTANCE; AFGHANISTAN; DEPRESSION; MORTALITY
AB Military personnel with Post-Traumatic Stress Disorder (PTSD) can experience high levels of mental and physical health comorbidity, potentially indicating a high level of functional impairment that can impact on both military readiness and later ill-health. There is strong evidence to implicate PTSD as a contributory factor to Cardiovascular Disease (CVD) among serving personnel and veterans. This systematic review focusses on the association between PTSD and cardiovascular disease/risk factors in male, military serving and ex-serving personnel who served in the Iraq/Afghanistan conflicts. PUBMED, MEDLINE, PILOTS, EMBASE, PSYCINFO, and PSYCARTICLES were searched using PRISMA guidelines. Three hundred and forty-three records were identified, of which 20 articles were selected. PTSD was positively associated with the development of CVD, specifically circulatory diseases, including hypertension. PTSD was also positively associated with the following risk factors: elevated heart rate, tobacco use, dyslipidaemia, and obesity. Conflicting data is presented regarding heart rate variability and inflammatory markers. Future studies would benefit from a standardized methodological approach to investigating PTSD and physical health manifestations. It is suggested that clinicians offer health advice for CVD at an earlier age for ex-/serving personnel with PTSD.
C1 [Dyball, Daniel; Evans, Sarah; Steyelink, Sharon A. M.; Fear, Nicola T.] Kings Coll London, Kings Ctr Mil Hlth Res, Psychol Med, London, England.
   [Dyball, Daniel; Evans, Sarah; Boos, Christopher J.; Fear, Nicola T.] Def Med Rehabil Ctr, Acad Dept Mil Rehabil, ADV Study, Stanford Hall, Loughborough, Leics, England.
   [Boos, Christopher J.] Bournemouth Univ, Dept Postgrad Med Educ, Poole, Dorset, England.
   [Steyelink, Sharon A. M.] Kings Coll London, Dept Psychol Med, London, England.
   [Fear, Nicola T.] Kings Coll London, Acad Dept Mil Mental Hlth, London, England.
C3 University of London; King's College London; Bournemouth University;
   University of London; King's College London; University of London;
   King's College London
RP Dyball, D (corresponding author), Kings Coll London, Kings Ctr Mil Hlth Res, Weston Educ Ctr, 10 Cutcombe Rd, London SE5 9RJ, England.
EM daniel.dyball@kcl.ac.uk
RI Fear, Nicola/A-1917-2012
OI Dyball, Daniel Mark/0000-0002-0547-8674; Stevelink,
   Sharon/0000-0002-7655-7986; Fear, Nicola/0000-0002-5792-2925; Evans,
   Sarah/0000-0002-6390-6729
FU Help for Heroes; Her Majesty's Treasury
FX The ADVANCE Study is funded by research grants from Help for Heroes and
   from Her Majesty's Treasury.
CR Agorastos A, 2013, STRESS, V16, P300, DOI 10.3109/10253890.2012.751369
   [Anonymous], ROLE LIPIDS LIPOPROT
   [Anonymous], 2018, Delphi method
   [Anonymous], THU0686 HEART RATE V
   [Anonymous], 2010, How tobacco smoke causes disease: the biology and behavioral basis for smoking-attributable disease: a report of the surgeon general
   [Anonymous], STUD QUAL ASS TOOLS
   [Anonymous], JRSM OPEN
   [Anonymous], 2014, FRONT PSYCHOL
   [Anonymous], SEM ARTHR REHEUM
   Bartoli F, 2013, METAB SYNDR RELAT D, V11, P301, DOI 10.1089/met.2013.0010
   Bedi US, 2007, J NATL MED ASSOC, V99, P642
   Bersani FS, 2016, BRAIN BEHAV IMMUN, V56, P264, DOI 10.1016/j.bbi.2016.03.021
   Black PH, 2003, BRAIN BEHAV IMMUN, V17, P350, DOI 10.1016/S0889-1591(03)00048-5
   Blessing EM, 2017, PSYCHONEUROENDOCRINO, V82, P91, DOI 10.1016/j.psyneuen.2017.04.016
   Boyles AL, 2011, EPIDEMIOLOGY, V22, P746, DOI 10.1097/EDE.0b013e318225ba48
   Burg MM, 2017, PSYCHOSOM MED, V79, P181, DOI 10.1097/PSY.0000000000000376
   Burke JF, 2013, NEUROLOGY, V81, P33, DOI 10.1212/WNL.0b013e318297eecf
   Buta E, 2018, EAT BEHAV, V29, P8, DOI 10.1016/j.eatbeh.2018.01.002
   Caska CM, 2014, HEALTH PSYCHOL, V33, P1273, DOI 10.1037/hea0000133
   Chalmers JA, 2014, FRONT PSYCHIATRY, V5, DOI 10.3389/fpsyt.2014.00080
   Cohen BE, 2015, AM J HYPERTENS, V28, P1295, DOI 10.1093/ajh/hpv047
   Cohen BE, 2009, JAMA-J AM MED ASSOC, V302, P489, DOI 10.1001/jama.2009.1084
   Coughlin SS, 2011, OPEN CARDIOVASC MED, V5, P164, DOI 10.2174/1874192401105010164
   Debell F, 2014, SOC PSYCH PSYCH EPID, V49, P1401, DOI 10.1007/s00127-014-0855-7
   Dhingra R, 2012, MED CLIN N AM, V96, P87, DOI 10.1016/j.mcna.2011.11.003
   Dinarello CA, 2000, CHEST, V118, P503, DOI 10.1378/chest.118.2.503
   Edmondson D, 2017, LANCET PSYCHIAT, V4, P320, DOI 10.1016/S2215-0366(16)30377-7
   Ferrari R, 1999, PHARMACOL RES, V40, P97, DOI 10.1006/phrs.1998.0463
   Foy AJ, 2018, AM J CARDIOL, V121, P1072, DOI 10.1016/j.amjcard.2018.01.019
   Franklin SS, 1999, J HYPERTENS, V17, pS29
   Frayne SM, 2011, J GEN INTERN MED, V26, P33, DOI 10.1007/s11606-010-1497-4
   Fulton JJ, 2015, J ANXIETY DISORD, V31, P98, DOI 10.1016/j.janxdis.2015.02.003
   Galatzer-Levy IR, 2013, DEPRESS ANXIETY, V30, P489, DOI 10.1002/da.22048
   Ghuran A, 2000, WESTERN J MED, V173, P412, DOI 10.1136/ewjm.173.6.412
   Ginsberg JP, 2010, ALTERN THER HEALTH M, V16, P52
   Grundy SM, 2016, TRENDS CARDIOVAS MED, V26, P364, DOI 10.1016/j.tcm.2015.10.004
   Guh DP, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-88
   Hansson GK, 2005, NEW ENGL J MED, V352, P1685, DOI 10.1056/NEJMra043430
   Hoerster KD, 2015, EAT BEHAV, V17, P115, DOI 10.1016/j.eatbeh.2015.01.005
   Japuntich SJ, 2016, PSYCHOL TRAUMA-US, V8, P123, DOI 10.1037/tra0000093
   Jin HF, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111760
   Kanda T, 2004, JPN HEART J, V45, P183, DOI 10.1536/jhj.45.183
   KANNEL WB, 1987, AM HEART J, V113, P1489, DOI 10.1016/0002-8703(87)90666-1
   Kirby AC, 2008, ADDICT BEHAV, V33, P1448, DOI 10.1016/j.addbeh.2008.05.007
   Klaassens ER, 2012, PSYCHONEUROENDOCRINO, V37, P317, DOI 10.1016/j.psyneuen.2011.07.003
   Kudielka BM, 2004, PSYCHONEUROENDOCRINO, V29, P83, DOI 10.1016/S0306-4530(02)00146-4
   La Rovere MT, 1998, LANCET, V351, P478
   Lerman I, 2016, PSYCHONEUROENDOCRINO, V73, P99, DOI 10.1016/j.psyneuen.2016.07.202
   Lindqvist D, 2017, BRAIN BEHAV IMMUN, V59, P260, DOI 10.1016/j.bbi.2016.09.012
   Lindqvist D, 2014, BRAIN BEHAV IMMUN, V42, P81, DOI 10.1016/j.bbi.2014.06.003
   Madjid M, 2011, BRIT MED BULL, V100, P23, DOI 10.1093/bmb/ldr043
   Maguen S, 2013, J GEN INTERN MED, V28, pS563, DOI 10.1007/s11606-013-2374-8
   Mendall MA, 2000, EUR HEART J, V21, P1584, DOI 10.1053/euhj.1999.1982
   Modan M, 1998, AM J CARDIOL, V82, P1242, DOI 10.1016/S0002-9149(98)00601-8
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Musselman DL, 1998, ARCH GEN PSYCHIAT, V55, P580, DOI 10.1001/archpsyc.55.7.580
   Nazarian D, 2012, J TRAUMA STRESS, V25, P220, DOI 10.1002/jts.21690
   Netea RT, 1998, J HYPERTENS, V16, P263, DOI 10.1097/00004872-199816030-00002
   Office of the Surgeon General (US); Office on Smoking and Health (US), 2004, HLTH CONS SMOK REP S
   Pacella ML, 2013, J ANXIETY DISORD, V27, P33, DOI 10.1016/j.janxdis.2012.08.004
   Passos IC, 2015, LANCET PSYCHIAT, V2, P1002, DOI 10.1016/S2215-0366(15)00309-0
   Paulus EJ, 2013, J TRAUMA STRESS, V26, P169, DOI 10.1002/jts.21785
   Perret-Guillaume C, 2009, PROG CARDIOVASC DIS, V52, P6, DOI 10.1016/j.pcad.2009.05.003
   Pitman RK, 2012, NAT REV NEUROSCI, V13, P769, DOI 10.1038/nrn3339
   Qureshi SU, 2009, PSYCHIAT QUART, V80, P87, DOI 10.1007/s11126-009-9096-4
   Ramaswamy Sriram, 2015, Innov Clin Neurosci, V12, P13
   Ramchand R, 2015, CURR PSYCHIAT REP, V17, DOI 10.1007/s11920-015-0575-z
   Ray JM, 2017, J NERV MENT DIS, V205, P793, DOI 10.1097/NMD.0000000000000718
   Richardson LK, 2010, AUST NZ J PSYCHIAT, V44, P4, DOI 10.3109/00048670903393597
   Ronksley Paul E, 2011, BMJ, V342, pd671, DOI 10.1136/bmj.d671
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Sardinha A, 2012, EXPERT REV ENDOCRINO, V7, P63, DOI [10.1586/EEM.11.89, 10.1586/eem.11.89]
   Schroecksnadel Katharina, 2006, Current Vascular Pharmacology, V4, P205, DOI 10.2174/157016106777698379
   Selvin E, 2004, ANN INTERN MED, V141, P421, DOI 10.7326/0003-4819-141-6-200409210-00007
   Smith KJ, 2018, DIABETIC MED, V35, P677, DOI 10.1111/dme.13606
   Stephens MAC, 2012, ALCOHOL RES-CURR REV, V34, P468
   Stevelink SAM, 2018, BRIT J PSYCHIAT, V213, P690, DOI 10.1192/bjp.2018.175
   Tan G, 2011, APPL PSYCHOPHYS BIOF, V36, P27, DOI 10.1007/s10484-010-9141-y
   Tan G, 2009, PAIN MED, V10, P1237, DOI 10.1111/j.1526-4637.2009.00712.x
   Thayer JF, 2010, INT J CARDIOL, V141, P122, DOI 10.1016/j.ijcard.2009.09.543
   Triposkiadis F, 2009, J AM COLL CARDIOL, V54, P1747, DOI 10.1016/j.jacc.2009.05.015
   Van Tassell BW, 2013, CIRCULATION, V128, P1910, DOI 10.1161/CIRCULATIONAHA.113.003199
   Wei TM, 2008, ACTA CLIN BELG, V63, P376, DOI 10.1179/acb.2008.078
   Welsh P, 2011, ARTERIOSCL THROM VAS, V31, P2338, DOI 10.1161/ATVBAHA.111.231795
   Whelton PK, 2002, JAMA-J AM MED ASSOC, V288, P1882, DOI 10.1001/jama.288.15.1882
   Whitman IR, 2017, J AM COLL CARDIOL, V69, P13, DOI 10.1016/j.jacc.2016.10.048
   Yehuda R, 2009, BIOL PSYCHIAT, V66, P708, DOI 10.1016/j.biopsych.2009.02.034
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
NR 89
TC 35
Z9 40
U1 1
U2 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0954-0261
EI 1369-1627
J9 INT REV PSYCHIATR
JI Int. Rev. Psych.
PD JAN 2
PY 2019
VL 31
IS 1
SI SI
BP 34
EP 48
DI 10.1080/09540261.2019.1580686
PG 15
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA IG0OD
UT WOS:000473489100005
PM 31041877
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Ma, L
   Li, Y
AF Ma, Lina
   Li, Yun
TI SIRT1: Role in cardiovascular biology
SO CLINICA CHIMICA ACTA
LA English
DT Review
DE SIRT1; Senescence; Cardiovascular biology; Expression regulation
ID ACTIVATED PROTEIN-KINASE; SMALL-MOLECULE ACTIVATORS; MYOCARDIAL
   GLUCOSE-UPTAKE; CARDIAC-HYPERTROPHY; METABOLIC SYNDROME; DEACETYLASE
   SIRT1; OXIDATIVE STRESS; MITOCHONDRIAL-FUNCTION; HISTONE DEACETYLASE;
   CELLULAR SENESCENCE
AB SIRT1 (silent information regulator two protein) is a type III protein deacetylase that regulates a variety of important metabolic and physiologic processes including stress resistance, metabolism, apoptosis and energy balance. It-reverses cholesterol transport and reduces risk for development of atherosclerosis and cardiovascular disease. The following review highlights the potential role of SIRT1 on cardiovascular biology and function. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Ma, Lina; Li, Yun] Capital Med Univ, Xuan Wu Hosp, Dept Geriatr, Beijing 100053, Peoples R China.
C3 Capital Medical University
RP Li, Y (corresponding author), Capital Med Univ, Xuan Wu Hosp, Dept Geriatr, 45 Changchun St, Beijing 100053, Peoples R China.
EM liy_xw@sina.com
RI Ma, Lina/R-6802-2016
OI Ma, Lina/0000-0001-7630-6960
FU MOE (Ministry of Education in China) Project of Humanities and Social
   Sciences [12YJCZH146]; Beijing Municipal Health Bureau Research Fund
   [Jing 13-02]
FX This work was supported by the following grants: MOE (Ministry of
   Education in China) Project of Humanities and Social Sciences
   (12YJCZH146), and Beijing Municipal Health Bureau Research Fund (Jing
   13-02).
CR Alcaín FJ, 2009, EXPERT OPIN THER PAT, V19, P283, DOI 10.1517/13543770902755111
   Alcendor RR, 2007, CIRC RES, V100, P1512, DOI 10.1161/01.RES.0000267723.65696.4a
   Alcendor RR, 2004, CIRC RES, V95, P971, DOI 10.1161/01.RES.0000147557.75257.ff
   Almeida L, 2009, MOL NUTR FOOD RES, V53, pS7, DOI 10.1002/mnfr.200800177
   [Anonymous], ARCH BIOCH BIOPHYS
   Aquilano K, 2010, J BIOL CHEM, V285, P21590, DOI 10.1074/jbc.M109.070169
   Arunachalam G, 2010, BIOCHEM BIOPH RES CO, V393, P66, DOI 10.1016/j.bbrc.2010.01.080
   Asher G, 2008, CELL, V134, P317, DOI 10.1016/j.cell.2008.06.050
   Barnea M, 2009, ENDOCRINOLOGY, V150, P161, DOI 10.1210/en.2008-0944
   Baur JA, 2006, NATURE, V444, P337, DOI 10.1038/nature05354
   Bhashyam S, 2010, CIRC-HEART FAIL, V3, P512, DOI 10.1161/CIRCHEARTFAILURE.109.900282
   Bolasco G, 2012, AGING-US, V4, P402, DOI 10.18632/aging.100464
   Boocock DJ, 2007, CANCER EPIDEM BIOMAR, V16, P1246, DOI 10.1158/1055-9965.EPI-07-0022
   Bradamante S, 2000, INT J TISSUE REACT, V22, P1
   Bradamante S, 2003, EUR J PHARMACOL, V465, P115, DOI 10.1016/S0014-2999(03)01441-9
   Breen DM, 2008, BIOCHEM BIOPH RES CO, V374, P117, DOI 10.1016/j.bbrc.2008.06.104
   Brunet A, 2004, SCIENCE, V303, P2011, DOI 10.1126/science.1094637
   Caito S, 2010, FASEB J, V24, P3145, DOI 10.1096/fj.09-151308
   Cantó C, 2009, NATURE, V458, P1056, DOI 10.1038/nature07813
   Cardellini M, 2009, DIABETES, V58, P2396, DOI 10.2337/db09-0280
   Chan AYM, 2008, J BIOL CHEM, V283, P24194, DOI 10.1074/jbc.M802869200
   Chao YM, 2013, HYPERTENSION, V61, P1270, DOI 10.1161/HYPERTENSIONAHA.111.00469
   Chen CJ, 2009, BIOCHEM BIOPH RES CO, V378, P389, DOI 10.1016/j.bbrc.2008.11.110
   Cheng HL, 2003, P NATL ACAD SCI USA, V100, P10794, DOI 10.1073/pnas.1934713100
   Cohen HY, 2004, SCIENCE, V305, P390, DOI 10.1126/science.1099196
   Cohen HY, 2004, MOL CELL, V13, P627, DOI 10.1016/S1097-2765(04)00094-2
   Dai DF, 2012, CIRC RES, V110, P1109, DOI 10.1161/CIRCRESAHA.111.246140
   Dasgupta B, 2007, P NATL ACAD SCI USA, V104, P7217, DOI 10.1073/pnas.0610068104
   Davis PA, 2013, HYPERTENS RES, V36, P873, DOI 10.1038/hr.2013.48
   Feige JN, 2008, CELL METAB, V8, P347, DOI 10.1016/j.cmet.2008.08.017
   Finkel T, 2009, NATURE, V460, P587, DOI 10.1038/nature08197
   Fontana L, 2012, CIRC RES, V110, P1139, DOI 10.1161/CIRCRESAHA.111.246470
   Freitas WM, 2012, ATHEROSCLEROSIS, V225, P281, DOI 10.1016/j.atherosclerosis.2012.06.070
   Frye RA, 2000, BIOCHEM BIOPH RES CO, V273, P793, DOI 10.1006/bbrc.2000.3000
   Fujitaka K, 2011, NUTR RES, V31, P842, DOI 10.1016/j.nutres.2011.09.028
   Fulco M, 2008, DEV CELL, V14, P661, DOI 10.1016/j.devcel.2008.02.004
   Fulco M, 2008, CELL CYCLE, V7, P3669, DOI 10.4161/cc.7.23.7164
   Furukawa A, 2007, CELL PHYSIOL BIOCHEM, V20, P45, DOI 10.1159/000104152
   Fyhrquist F, 2012, ANN MED, V44, pS138, DOI 10.3109/07853890.2012.660497
   Gasser SM, 2001, GENE, V279, P1, DOI 10.1016/S0378-1119(01)00741-7
   Gillum MP, 2011, DIABETES, V60, P3235, DOI 10.2337/db11-0616
   Gottlieb RA, 2009, BASIC RES CARDIOL, V104, P169, DOI 10.1007/s00395-009-0011-9
   Gracia-Sancho J, 2010, CARDIOVASC RES, V85, P514, DOI 10.1093/cvr/cvp337
   Guarente L, 1999, NAT GENET, V23, P281, DOI 10.1038/15458
   Hariharan N, 2010, CIRC RES, V107, P1470, DOI 10.1161/CIRCRESAHA.110.227371
   He CC, 2009, ANNU REV GENET, V43, P67, DOI 10.1146/annurev-genet-102808-114910
   Hou XY, 2008, J BIOL CHEM, V283, P20015, DOI 10.1074/jbc.M802187200
   Howitz KT, 2003, NATURE, V425, P191, DOI 10.1038/nature01960
   Hsu CP, 2008, BIOL CHEM, V389, P221, DOI 10.1515/BC.2008.032
   Hua YN, 2011, BASIC RES CARDIOL, V106, P1173, DOI 10.1007/s00395-011-0222-8
   Huhtiniemi T, 2006, J COMPUT AID MOL DES, V20, P589, DOI 10.1007/s10822-006-9084-9
   Hung LM, 2004, FREE RADICAL BIO MED, V36, P774, DOI 10.1016/j.freeradbiomed.2003.12.016
   Imamura G, 2002, AM J PHYSIOL-HEART C, V282, pH1996, DOI 10.1152/ajpheart.01013.2001
   Kawashima T, 2011, J MOL CELL CARDIOL, V51, P1026, DOI 10.1016/j.yjmcc.2011.09.013
   Kilic U, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0090428
   Kim S, 2012, BIOGERONTOLOGY, V13, P119, DOI 10.1007/s10522-011-9360-5
   Kohsaka A, 2007, CELL METAB, V6, P414, DOI 10.1016/j.cmet.2007.09.006
   Kovacic JC, 2011, CIRCULATION, V123, P1650, DOI 10.1161/CIRCULATIONAHA.110.007021
   Lagouge M, 2006, CELL, V127, P1109, DOI 10.1016/j.cell.2006.11.013
   Lawson M, 2010, BBA-GENE REGUL MECH, V1799, P726, DOI 10.1016/j.bbagrm.2010.06.003
   Lee IH, 2008, P NATL ACAD SCI USA, V105, P3374, DOI 10.1073/pnas.0712145105
   Lee JS, 2010, EXP DERMATOL, V19, P1060, DOI 10.1111/j.1600-0625.2010.01129.x
   Li L, 2011, ACTA BIOCH BIOPH SIN, V43, P103, DOI 10.1093/abbs/gmq104
   Li L, 2009, CAN J PHYSIOL PHARM, V87, P56, DOI 10.1139/Y08-099
   Li X, 2007, MOL CELL, V28, P91, DOI 10.1016/j.molcel.2007.07.032
   Lu ZP, 2009, CIRC RES, V105, P830, DOI 10.1161/CIRCRESAHA.109.204974
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Mantel C, 2008, CURR OPIN HEMATOL, V15, P326, DOI 10.1097/MOH.0b013e3283043819
   Mattagajasingh I, 2007, P NATL ACAD SCI USA, V104, P14855, DOI 10.1073/pnas.0704329104
   McBurney MW, 2003, MOL CELL BIOL, V23, P38, DOI 10.1128/MCB.23.1.38-54.2003
   Michan S, 2007, BIOCHEM J, V404, P1, DOI 10.1042/BJ20070140
   Milne JC, 2007, NATURE, V450, P712, DOI 10.1038/nature06261
   Miyazaki R, 2008, ARTERIOSCL THROM VAS, V28, P1263, DOI 10.1161/ATVBAHA.108.166991
   Nadtochiy SM, 2011, AM J PHYSIOL-HEART C, V301, pH1506, DOI 10.1152/ajpheart.00587.2011
   Nakahata Y, 2008, CELL, V134, P329, DOI 10.1016/j.cell.2008.07.002
   Nakai A, 2007, NAT MED, V13, P619, DOI 10.1038/nm1574
   Nikolaidis LA, 2004, CIRCULATION, V110, P955, DOI 10.1161/01.CIR.0000139339.85840.DD
   Nilsson PM, 2012, J HYPERTENS        S, V30, P9
   Nishida K, 2009, CELL DEATH DIFFER, V16, P31, DOI 10.1038/cdd.2008.163
   North BJ, 2012, CIRC RES, V110, P1097, DOI 10.1161/CIRCRESAHA.111.246876
   Ohguchi K, 2010, BRIT J DERMATOL, V163, P689, DOI 10.1111/j.1365-2133.2010.09825.x
   Oka S, 2011, CELL METAB, V14, P598, DOI 10.1016/j.cmet.2011.10.001
   Orallo F, 2002, MOL PHARMACOL, V61, P294, DOI 10.1124/mol.61.2.294
   Ota H, 2007, J MOL CELL CARDIOL, V43, P571, DOI 10.1016/j.yjmcc.2007.08.008
   Pillai JB, 2005, J BIOL CHEM, V280, P43121, DOI 10.1074/jbc.M506162200
   Planavila A, 2011, CARDIOVASC RES, V90, P276, DOI 10.1093/cvr/cvq376
   Potente M, 2007, GENE DEV, V21, P2644, DOI 10.1101/gad.435107
   Price NL, 2012, CELL METAB, V15, P675, DOI 10.1016/j.cmet.2012.04.003
   Purushotham A, 2009, CELL METAB, V9, P327, DOI 10.1016/j.cmet.2009.02.006
   Rajendran R, 2011, J BIOMED BIOTECHNOL, DOI 10.1155/2011/368276
   Ramsey KM, 2009, SCIENCE, V324, P651, DOI 10.1126/science.1171641
   Rodgers JT, 2005, NATURE, V434, P113, DOI 10.1038/nature03354
   Sakamoto J, 2004, FEBS LETT, V556, P281, DOI 10.1016/S0014-5793(03)01444-3
   Salminen A, 2013, INT J MOL SCI, V14, P3834, DOI 10.3390/ijms14023834
   Salminen A, 2012, AGING-US, V4, P166, DOI 10.18632/aging.100444
   Salminen A, 2012, AGEING RES REV, V11, P230, DOI 10.1016/j.arr.2011.12.005
   Salminen A, 2011, J MOL MED, V89, P667, DOI 10.1007/s00109-011-0748-0
   Salvati E, 2010, ONCOGENE, V29, P6280, DOI 10.1038/onc.2010.344
   Sano M, 2007, NATURE, V446, P444, DOI 10.1038/nature05602
   Schmidt-Schweda S, 2000, CLIN SCI, V99, P27, DOI 10.1042/CS19990235
   Shang J, 2008, ACTA PHARMACOL SIN, V29, P698, DOI 10.1111/j.1745-7254.2008.00807.x
   Shiojima I, 2005, J CLIN INVEST, V115, P2108, DOI 10.1172/JCI24682
   Smith BC, 2008, CHEM BIOL, V15, P1002, DOI 10.1016/j.chembiol.2008.09.009
   Smith JS, 2002, TRENDS CELL BIOL, V12, P404, DOI 10.1016/S0962-8924(02)02342-5
   Stein S, 2011, CELL CYCLE, V10, P640, DOI 10.4161/cc.10.4.14863
   Streppel MT, 2009, J EPIDEMIOL COMMUN H, V63, P534, DOI 10.1136/jech.2008.082198
   Sulaiman M, 2010, AM J PHYSIOL-HEART C, V298, pH833, DOI 10.1152/ajpheart.00418.2009
   Sun C, 2007, CELL METAB, V6, P307, DOI 10.1016/j.cmet.2007.08.014
   Sundaresan NR, 2008, MOL CELL BIOL, V28, P6384, DOI 10.1128/MCB.00426-08
   Tanno M, 2010, J BIOL CHEM, V285, P8375, DOI 10.1074/jbc.M109.090266
   Timmers S, 2011, CELL METAB, V14, P612, DOI 10.1016/j.cmet.2011.10.002
   Turdi S, 2010, AGING CELL, V9, P592, DOI 10.1111/j.1474-9726.2010.00586.x
   Turek FW, 2005, SCIENCE, V308, P1043, DOI 10.1126/science.1108750
   Um JH, 2010, DIABETES, V59, P554, DOI 10.2337/db09-0482
   Vahtolaa E, 2008, J HYPERTENS, V26, P334, DOI 10.1097/HJH.0b013e3282f293c8
   van Gent R, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0098438
   Vinciguerra M, 2012, AGING CELL, V11, P139, DOI 10.1111/j.1474-9726.2011.00766.x
   Wang ZV, 2013, HEART FAIL REV, V18, P585, DOI 10.1007/s10741-012-9350-y
   Wang ZV, 2010, J BIOL CHEM, V285, P8509, DOI 10.1074/jbc.R109.025023
   Wang ZR, 2002, INT J MOL MED, V9, P77
   Wong RHX, 2011, NUTR METAB CARDIOVAS, V21, P851, DOI 10.1016/j.numecd.2010.03.003
   Xia N, 2013, NITRIC OXIDE-BIOL CH, V32, P29, DOI 10.1016/j.niox.2013.04.001
   XIE QW, 1994, J BIOL CHEM, V269, P4705
   Xiong SQ, 2011, J BIOL CHEM, V286, P5289, DOI 10.1074/jbc.M110.163667
   Yamamoto T, 2011, TRENDS CARDIOVAS MED, V21, P27, DOI 10.1016/j.tcm.2012.01.005
   Yamashita S, 2012, BIOCHEM BIOPH RES CO, V417, P630, DOI 10.1016/j.bbrc.2011.12.021
   Yan L, 2005, P NATL ACAD SCI USA, V102, P13807, DOI 10.1073/pnas.0506843102
   Yang Y, 2013, FREE RADICAL BIO MED, V65, P667, DOI 10.1016/j.freeradbiomed.2013.07.007
   Yao HW, 2012, BIOCHEM PHARMACOL, V84, P1332, DOI 10.1016/j.bcp.2012.06.031
   Yoshizaki T, 2009, MOL CELL BIOL, V29, P1363, DOI 10.1128/MCB.00705-08
   Zhang QJ, 2008, CARDIOVASC RES, V80, P191, DOI 10.1093/cvr/cvn224
   Zhang T, 2010, BBA-PROTEINS PROTEOM, V1804, P1666, DOI 10.1016/j.bbapap.2009.10.022
NR 132
TC 49
Z9 54
U1 1
U2 20
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD FEB 2
PY 2015
VL 440
BP 8
EP 15
DI 10.1016/j.cca.2014.10.036
PG 8
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA CB4BT
UT WOS:000349573900004
PM 25444742
DA 2025-06-11
ER

PT J
AU das Merces, MC
   Santana, AIC
   Lua, I
   da Silva, DAR
   Silva, DDE
   Gomes, AMT
   Miranda, MCD
   Barbosa, CD
   Magalhaes, LBNC
   Coelho, JMF
   Servo, MLS
   Portella, DDA
   de Souza, MC
   Lago, SB
   Araújo, EMQ
   Marques, SC
   Figueiredo, VP
   D'Oliveira, A
AF das Merces, Magno Conceicao
   Costa Santana, Amalia Ivine
   Lua, Iracema
   Reis da Silva, Dandara Almeida
   de Souza e Silva, Douglas
   Tosoli Gomes, Antonio Marcos
   das Merces Miranda, Manuela Conceicao
   Barbosa, Caroline da Silva
   Neves Cunha Magalhaes, Lucelia Batista
   Freitas Coelho, Julita Maria
   Silva Servo, Maria Lucia
   Alves Portella, Daniel Deivson
   de Souza, Marcio Costa
   Lago, Sueli Bonfim
   Queiroz Araujo, Edilene Maria
   Marques, Sergio Correa
   Figueiredo, Virginia Paiva
   D'Oliveira Junior, Argemiro
TI Metabolic Syndrome Among Primary Health Care Nursing Professionals: A
   Cross-Sectional Population-Based Study
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE metabolic syndrome; nursing; primary health care; work
ID CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; PREVALENCE; EXERCISE;
   STRESS; ASSOCIATION; OVERWEIGHT; PROGRAM; OBESITY; WORKERS
AB This research aims at evaluating prevalence and factors associated with metabolic syndrome (MS) in primary health care (PHC) nursing professionals. A multicenter, population-based and cross-sectional study was conducted in a team-tested sample of 1125 PHC nurses in the state of Bahia, Brazil. Sociodemographic, labor, lifestyle and human biology variables were investigated by mean of anamnesis. MS was evaluated according to the criteria of the first Brazilian Guideline for Metabolic Syndrome, which fully adopts the criteria of the National Cholesterol Education Program's Adult Treatment Panel III. MS-associated factors were tested by using robust Poisson Regression. The prevalence of MS found was 24.4%; low High Density Lipoprotein (HDL) cholesterol was the most prevalent component of the syndrome. In the multivariate analysis, physical inactivity (PR = 1.25, 95% CI = 1.02-1.53), alcohol use (PR = 1.84, 95% CI = 1.22-2.77), acanthosis nigricans (PR = 3.23, 95% CI = 2.65-3.92), burnout syndrome (PR = 1.45, 95% CI = 1.17-1.81), (PR = 1.37, 95% CI = 1.12-1.69), working as a nursing technician (PR = 1.43, 95% CI = 1.14-1.80), were associated to MS. It was found that the prevalence of MS was high, which evidences the need for interventions in the PHC environment, improvement of working conditions, monitoring of worker safety and health, diet programs and physical activity.
C1 [das Merces, Magno Conceicao; Reis da Silva, Dandara Almeida; das Merces Miranda, Manuela Conceicao; Freitas Coelho, Julita Maria; Alves Portella, Daniel Deivson; de Souza, Marcio Costa; Lago, Sueli Bonfim; Queiroz Araujo, Edilene Maria] State Univ Bahia UNEB, Dept Life Sci, BR-41150000 Salvador, BA, Brazil.
   [das Merces, Magno Conceicao; Costa Santana, Amalia Ivine; de Souza e Silva, Douglas; Barbosa, Caroline da Silva; D'Oliveira Junior, Argemiro] Fed Univ Bahia UFBA, Sch Med, Hlth Sci Postgrad Program, BR-40026010 Salvador, BA, Brazil.
   [Lua, Iracema; Silva Servo, Maria Lucia] State Univ Feira de Santana UEFS, Dept Hlth, BR-44036900 Feira De Santana, Brazil.
   [Tosoli Gomes, Antonio Marcos; Marques, Sergio Correa; Figueiredo, Virginia Paiva] State Univ Rio de Janeiro UERJ, Sch Nursing, BR-20551030 Rio De Janeiro, Brazil.
   [Neves Cunha Magalhaes, Lucelia Batista] Fed Univ Bahia UFBA, Sch Med, Dept Family Hlth, BR-40026010 Salvador, BA, Brazil.
C3 Universidade do Estado Bahia; Universidade Estadual de Feira de Santana;
   Universidade do Estado do Rio de Janeiro
RP das Merces, MC (corresponding author), State Univ Bahia UNEB, Dept Life Sci, BR-41150000 Salvador, BA, Brazil.; das Merces, MC (corresponding author), Fed Univ Bahia UFBA, Sch Med, Hlth Sci Postgrad Program, BR-40026010 Salvador, BA, Brazil.
EM magnomerces@hotmail.com
RI Lua, Iracema/AAR-2466-2021; MAGALHÃES, LUCELIA/AAA-1378-2019; Merces,
   Magno/S-6649-2017; Gomes, A./Q-6844-2016; Costa de Souza,
   Marcio/Y-8859-2018
OI DE SOUZA E SILVA, DOUGLAS/0000-0003-4476-7767; Merces, Magno Conceicao
   das/0000-0003-3493-8606; Maria Queiroz Araujo,
   Edilene/0000-0003-0481-037X; Deivson Alves Portella,
   Daniel/0000-0002-0315-9987; Coelho, Julita/0000-0002-9520-5177; Costa de
   Souza, Marcio/0000-0002-4922-6786
FU National Council for Scientific and Technological Development (CNPq),
   Brazil [408390/2016-6]
FX Financial support from the National Council for Scientific and
   Technological Development (CNPq), Brazil, Universal Call Notice-protocol
   #408390/2016-6.
CR Aballay LR, 2013, NUTR REV, V71, P168, DOI 10.1111/j.1753-4887.2012.00533.x
   Alegría E, 2005, REV ESP CARDIOL, V58, P797, DOI 10.1157/13077231
   [Anonymous], 2005, ARQ BRAS CARDIOL, V84, P1
   [Anonymous], RBAC
   [Anonymous], 1997, THESIS
   Aune D, 2017, EUR J EPIDEMIOL, V32, P181, DOI 10.1007/s10654-017-0232-4
   Ayaz T, 2014, METAB SYNDR RELAT D, V12, P320, DOI 10.1089/met.2013.0145
   Bortoletto Maira Sayuri Sakay, 2016, Cad. saúde colet., V24, P32, DOI 10.1590/1414-462X201600010123
   Brazilian Office of Geography and Statistics (IBGE), 1990, REG DEP BRAZ MES MIC
   Costa LOBF, 2007, REV BRAS GINECOL OBS, V29, P10
   Carneiro AS, 2016, REV PED SOPERJ, V16, P8
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Chini Luiz Stanislau Nunes, 2014, Cad. saúde colet., V22, P359, DOI 10.1590/1414-462X201400040009
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Colberg SR, 2010, DIABETES CARE, V33, P2692, DOI [10.2337/dc10-1548, 10.2337/dc10-9990]
   Coutinho Leticia M S, 2008, Rev. Saúde Pública, V42, P992, DOI 10.1590/S0034-89102008000600003
   das Merces MC, 2016, PSICOL-REFLEX CRIT, V29, DOI 10.1186/s41155-016-0051-7
   Davila EP, 2010, DIABETES CARE, V33, P2390, DOI 10.2337/dc10-0681
   Francisco Priscila Maria S. Bergamo, 2008, Rev. bras. epidemiol., V11, P347
   Gomes IS, 2016, J PERIODONTOL, V87, P357, DOI 10.1902/jop.2015.150367
   Hu G, 2004, ARCH INTERN MED, V164, P1066, DOI 10.1001/archinte.164.10.1066
   Jackson S., 1986, Maslach Burnout Inventory Manual, V2nd
   Kitaoka-Higashiguchi K, 2009, J OCCUP HEALTH, V51, P123, DOI 10.1539/joh.L8104
   Kumanyika SK, 2008, ANNU REV PUBL HEALTH, V29, P297, DOI 10.1146/annurev.publhealth.29.091307.083415
   Maslach C, 2001, ANNU REV PSYCHOL, V52, P397, DOI 10.1146/annurev.psych.52.1.397
   Maslach C, 1986, MASLACH BURNOUT INVE
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Melamed S, 2006, PSYCHOL BULL, V132, P327, DOI 10.1037/0033-2909.132.3.327
   Merces MC, 2016, REV BAIANA ENFERM, V30, P1, DOI [DOI 10.1371/journal.pone.0185781, 10.18471/rbe.v30i3.15645]
   Metlaine A, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0190607
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Nair Chitra V, 2010, Indian J Community Med, V35, P122, DOI 10.4103/0970-0218.62569
   Ramires EKNM, 2018, ARQ BRAS CARDIOL, V110, P455, DOI 10.5935/abc.20180072
   Ramirez AJ, 1996, LANCET, V347, P724, DOI 10.1016/S0140-6736(96)90077-X
   Ranchal Sánchez Antonio, 2008, Med. segur. trab., V54, P47, DOI 10.4321/s0465-546x2008000200007
   Ribeiro Renata Perfeito, 2018, Rev. Gaúcha Enferm., V39, pe65127, DOI 10.1590/1983-1447.2018.65127
   Ribeiro RP, 2015, REV LAT-AM ENFERM, V23, P435
   Ribeiro RP, 2011, ACTA PAUL ENFERM, V24, P577, DOI 10.1590/S0103-21002011000400020
   Rodríguez-Artalejo F, 2011, REV ESP CARDIOL, V64, P876, DOI 10.1016/j.recesp.2011.05.019
   SEIGEL DG, 1992, AM J EPIDEMIOL, V135, P571, DOI 10.1093/oxfordjournals.aje.a116324
   Simao AF, 2013, ARQ BRAS CARDIOL, V101, P2
   Sposito AC, 2007, ARQ BRAS CARDIOL, V88, P2, DOI 10.1590/S0066-782X2007000700002
   Stern SE, 2005, DIABETES, V54, P333, DOI 10.2337/diabetes.54.2.333
   Felipe-de-Melo ERT, 2011, CIENC SAUDE COLETIVA, V16, P3443, DOI 10.1590/S1413-81232011000900012
   Tsai HH, 2013, IND HEALTH, V51, P336, DOI 10.2486/indhealth.2012-0188
   Tsai TY, 2011, CLINICS, V66, P1531, DOI 10.1590/S1807-59322011000900004
   Wang JJ, 2012, ANTIOXID REDOX SIGN, V17, P282, DOI 10.1089/ars.2011.4381
   Xiao J, 2015, NUTR METAB, V12, DOI 10.1186/s12986-015-0007-4
NR 48
TC 21
Z9 21
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD AUG 1
PY 2019
VL 16
IS 15
AR 2686
DI 10.3390/ijerph16152686
PG 13
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA IS4MU
UT WOS:000482128400055
PM 31357596
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU More, VR
   Xu, JL
   Shimpi, PC
   Belgrave, C
   Luyendyk, JP
   Yamamoto, M
   Slitt, AL
AF More, Vijay R.
   Xu, Jialin
   Shimpi, Prajakta C.
   Belgrave, Clyde
   Luyendyk, James P.
   Yamamoto, Masayuki
   Slitt, Angela L.
TI Keap1 knockdown increases markers of metabolic syndrome after long-term
   high fat diet feeding
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Nrf2; Keap1; Steatosis; Metabolic syndrome; Free radicals
ID GENE-EXPRESSION; INSULIN-RESISTANCE; INDUCED OBESITY; TRANSPORTER
   EXPRESSION; NRF2 ACTIVATION; ADIPOSE-TISSUE; LIVER-INJURY; MOUSE-LIVER;
   MICE; DISEASE
AB The nuclear factor E2-related factor 2 (Nrf2)-Kelch-like ECH-associated protein 1 (Keap1) pathway upregulates antioxidant and biotransformation enzyme expression to counter cellular oxidative stress. The contributions of Nrf2 to other cellular functions, such as lipid homeostasis, are emerging. This study was conducted to determine how enhanced Nrf2 activity influences the progression of metabolic syndrome with long-term high-fat diet (HFD) feeding. C57BL/6 and Keap1-knockdown (Keap1-KD) mice, which exhibit enhanced Nrf2 activity, were fed a HFD for 24 weeks. Keap1-KD mice had higher body weight and white adipose tissue mass compared to C57BL/6 mice on HFD, along with increased inflammation and lipogenic gene expression. HFD feeding increased hepatic steatosis and inflammation to a greater extent in Keap1-KD mice compared to C57BL/6 mice, which was associated with increased liver Cd36, fatty acid-binding protein 4, and monocyte chemoattractant protein 1 mRNA expression, as well as increased acetyl-CoA carboxylase 1 and stearoyl-CoA desaturase-1 protein expression. The HFD altered short-term glucose homeostasis to a greater degree in Keap-KD mice compared to C57BL/6 mice, which was accompanied by downregulation of insulin receptor substrate 1 mRNA expression in skeletal muscle. Together, the results indicate that Keap1 knockdown, on treatment with HFD, increases certain markers of metabolic syndrome. (C) 2013 Elsevier Inc. All rights reserved.
C1 [More, Vijay R.; Xu, Jialin; Shimpi, Prajakta C.; Slitt, Angela L.] Univ Rhode Isl, Dept Biomed & Pharmaceut Sci, Kingston, RI 02881 USA.
   [Belgrave, Clyde] Providence VA Med Ctr, Providence, RI 02908 USA.
   [Luyendyk, James P.] Michigan State Univ, E Lansing, MI 48824 USA.
   [Yamamoto, Masayuki] Tohoku Univ, Div Med Biochem, Grad Sch Med, Sendai, Miyagi 980, Japan.
C3 University of Rhode Island; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); Providence VA Medical Center; Michigan
   State University; Tohoku University
RP Slitt, AL (corresponding author), Univ Rhode Isl, Dept Biomed & Pharmaceut Sci, Kingston, RI 02881 USA.
EM aslitt@uri.edu
RI Yamamoto, Masayuki/A-4873-2010
FU National Institutes of Health [1R01ES016042, 5K22ES013782]; National
   Center for Research Resources [5P20RR016457-11]; Institute for General
   Medical Science components of the National Institutes of Health [8P20
   GM103430-11]; Society of Toxicology Association of Scientists of Indian
   Origin
FX The authors thank Dr. Curtis D. Klaassen (University of Kansas Medical
   School) for generously sharing Keap1-KD mice. This work was supported by
   grants from the National Institutes of Health (1R01ES016042,
   5K22ES013782) and the National Center for Research Resources
   (5P20RR016457-11) and Institute for General Medical Science (8P20
   GM103430-11) components of the National Institutes of Health. This work
   was presented, in part, at the annual Society of Toxicology meeting held
   in San Francisco on 11-15 March 2012 and was awarded the Dr. Laxman
   Desai Graduate Student Best Abstract Award from the Society of
   Toxicology Association of Scientists of Indian Origin.
CR [Anonymous], NATL HLTH STAT REPOR
   Biswas M, 2010, TOXICOL APPL PHARM, V244, P16, DOI 10.1016/j.taap.2009.07.034
   Chandler KJ, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0018540
   Chartoumpekis DV, 2011, DIABETES, V60, P2465, DOI 10.2337/db11-0112
   Chawla A, 2011, NAT REV IMMUNOL, V11, P738, DOI 10.1038/nri3071
   Chinetti-Gbaguidi G, 2011, CURR OPIN LIPIDOL, V22, P365, DOI 10.1097/MOL.0b013e32834a77b4
   Greenfield JR, 2006, CURR DIABETES REV, V2, P195, DOI 10.2174/157339906776818532
   Haffner SM, 2006, OBESITY, V14, p121S, DOI 10.1038/oby.2006.291
   Halberg N, 2008, ENDOCRIN METAB CLIN, V37, P753, DOI 10.1016/j.ecl.2008.07.002
   Hartley DP, 2000, DRUG METAB DISPOS, V28, P608
   Horton JD, 2002, J CLIN INVEST, V109, P1125, DOI 10.1172/JCI200215593
   Huang JS, 2010, AM J PHYSIOL-GASTR L, V299, pG1211, DOI 10.1152/ajpgi.00322.2010
   Iozzo P., 2009, DIABETES CARE S2, V32, pS168
   Kahn SE, 2006, NATURE, V444, P840, DOI 10.1038/nature05482
   Kassel KM, 2012, AM J PATHOL, V181, P1287, DOI 10.1016/j.ajpath.2012.06.011
   Kay HY, 2011, ANTIOXID REDOX SIGN, V15, P2135, DOI 10.1089/ars.2010.3834
   Klaassen CD, 2010, TOXICOL APPL PHARM, V244, P57, DOI 10.1016/j.taap.2010.01.013
   Kobayashi A, 2004, METHOD ENZYMOL, V378, P273
   Koppen A, 2010, FEBS LETT, V584, P3250, DOI 10.1016/j.febslet.2010.06.035
   Kwong M, 1999, J BIOL CHEM, V274, P37491, DOI 10.1074/jbc.274.52.37491
   Lamlé J, 2008, GASTROENTEROLOGY, V134, P1159, DOI 10.1053/j.gastro.2008.01.011
   Lee YH, 2011, METABOLISM, V60, P1664, DOI 10.1016/j.metabol.2011.04.008
   Marmugi A, 2012, HEPATOLOGY, V55, P395, DOI 10.1002/hep.24685
   Mead JR, 2002, J MOL MED, V80, P753, DOI 10.1007/s00109-002-0384-9
   More Vijay R, 2012, Comp Hepatol, V11, P1, DOI 10.1186/1476-5926-11-1
   More VR, 2011, DRUG METAB DISPOS, V39, P992, DOI 10.1124/dmd.110.037507
   Okada K, 2012, J GASTROENTEROL, V47, P924, DOI 10.1007/s00535-012-0552-9
   Pi JB, 2010, J BIOL CHEM, V285, P9292, DOI 10.1074/jbc.M109.093955
   Piton A, 2010, TOXICOL IN VITRO, V24, P452, DOI 10.1016/j.tiv.2009.09.025
   Reisman SA, 2009, TOXICOL APPL PHARM, V236, P109, DOI 10.1016/j.taap.2008.12.024
   Reisman SA, 2009, TOXICOL SCI, V108, P35, DOI 10.1093/toxsci/kfn267
   Shin S, 2009, EUR J PHARMACOL, V620, P138, DOI 10.1016/j.ejphar.2009.08.022
   SUN XJ, 1991, NATURE, V352, P73, DOI 10.1038/352073a0
   Taguchi K, 2010, MOL CELL BIOL, V30, P3016, DOI 10.1128/MCB.01591-09
   Tang QQ, 2003, P NATL ACAD SCI USA, V100, P850, DOI 10.1073/pnas.0337434100
   Tkachev VO, 2011, BIOCHEMISTRY-MOSCOW+, V76, P407, DOI 10.1134/S0006297911040031
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Wu KC, 2012, TOXICOL APPL PHARM, V263, P14, DOI 10.1016/j.taap.2012.05.017
   Wu KC, 2012, FREE RADICAL RES, V46, P1220, DOI 10.3109/10715762.2012.700709
   Wu KC, 2011, TOXICOL SCI, V123, P590, DOI 10.1093/toxsci/kfr183
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Xu J., 2012, DIABETES, V61, P1
   Xu JL, 2012, DIABETES, V61, P3208, DOI 10.2337/db11-1716
   Xu JL, 2012, DRUG METAB DISPOS, V40, P259, DOI 10.1124/dmd.111.039925
   Yates MS, 2009, CARCINOGENESIS, V30, P1024, DOI 10.1093/carcin/bgp100
   Yu Z, 2011, DIABETOLOGIA, V54, P922, DOI 10.1007/s00125-010-2001-8
   Zhang YKJ, 2012, TOXICOL APPL PHARM, V264, P305, DOI 10.1016/j.taap.2012.09.014
   Zhao R, 2012, ENVIRON HEALTH PERSP, V120, P583, DOI 10.1289/ehp.1104580
   Zorzano A, 2005, ACTA PHYSIOL SCAND, V183, P43, DOI 10.1111/j.1365-201X.2004.01380.x
NR 49
TC 46
Z9 54
U1 0
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD AUG
PY 2013
VL 61
BP 85
EP 94
DI 10.1016/j.freeradbiomed.2013.03.007
PG 10
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 168EA
UT WOS:000320687300010
PM 23507082
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Kagota, S
   Yamaguchi, Y
   Tanaka, N
   Kubota, Y
   Kobayashi, K
   Nejime, N
   Nakamura, K
   Kunitomo, M
   Shinozuka, K
AF Kagota, S
   Yamaguchi, Y
   Tanaka, N
   Kubota, Y
   Kobayashi, K
   Nejime, N
   Nakamura, K
   Kunitomo, M
   Shinozuka, K
TI Disturbances in nitric oxide/cyclic guanosine monophosphate system in
   SHR/NDmcr-cp rats, a model of metabolic syndrome
SO LIFE SCIENCES
LA English
DT Article
DE endothelium; metabolic syndrome; nitric oxide; vascular smooth muscle;
   vasorelaxation
ID SOLUBLE GUANYLYL CYCLASE; SPONTANEOUSLY HYPERTENSIVE-RATS; OBESE ZUCKER
   RAT; LA-CORPULENT RAT; INSULIN-RESISTANCE; OXIDE SYNTHASE; VASCULAR
   DYSFUNCTION; ENDOTHELIAL FUNCTION; DOWN-REGULATION; NO SYNTHASE
AB Metabolic syndrome is a cluster of metabolic abnormalities, including hypertension, hyperlipidemia, hyperinsulinemia, glucose intolerance and obesity. In such lifestyle-related diseases, impairment of nitric oxide (NO) production or bioactivity has been reported to lead to the development of atherogenic vascular diseases. Therefore, in the present study we investigated changes in the NO/cyclic guanosine monophosphate (cGMP) system in aortas of SHR/NDmcr-cp (cp/cp) rats (SHR-cp), a model of the metabolic syndrome. In aortas of SHR-cp, endothelium-dependent relaxations induced by acetylcholine and endothelium-independent relaxations induced by sodium nitroprusside were significantly impaired in comparison with Wistar-Kyoto rats. Furthermore, protein levels of soluble guanyly cyclase and cGMP levels induced by sodium nitroprusside were significantly decreased. In contrast, protein levels of endothelium NO synthase and cGMP levels induced by acetylcholine were significantly increased, and plasma NO2 plus NO3 levels were also increased. The levels of lipid peroxide in plasma and the contents of 3-nitrotyrosine, a biomarker of peroxynitrite, in aortas were markedly increased. These findings indicate that in the aortas of SHR-cp, NO production from the endothelium, is augmented, although the NO-induced relaxation response is impaired. Enhanced NO production may be a compensatory response to a variety of factors, including increases in oxidative stress. (c) 2005 Elsevier Inc. All rights reserved.
C1 Mukogawa Womens Univ, Sch Pharmaceut Sci, Dept Pharmacol, Nishinomiya, Hyogo, Japan.
C3 Mukogawa Women's University
RP Kagota, S (corresponding author), 11-68 Koshien Kyuban Cho, Nishinomiya, Hyogo 6638179, Japan.
EM skagota@mwu.mukogawa-u.ac.jp
CR Andreopoulos S, 2000, GEN PHARMACOL-VASC S, V34, P147, DOI 10.1016/S0306-3623(00)00062-8
   AUGUET M, 1989, J PHARM PHARMACOL, V41, P861
   Brunner F, 2000, CARDIOVASC RES, V47, P150, DOI 10.1016/S0008-6363(00)00056-0
   Courtois E, 2003, J AM SOC NEPHROL, V14, P1464, DOI 10.1097/01.ASN.0000064947.14997.69
   Fulton D, 2004, AM J PHYSIOL-HEART C, V287, pH2384, DOI 10.1152/ajpheart.00280.2004
   FURCHGOTT RF, 1989, FASEB J, V3, P2007, DOI 10.1096/fasebj.3.9.2545495
   Hanafy K A, 2001, Med Sci Monit, V7, P801
   Hsueh WA, 2004, AM J MED, V117, P109, DOI 10.1016/j.amjmed.2004.02.042
   Kagota S, 2004, J CARDIOVASC PHARM, V44, P42, DOI 10.1097/00005344-200407000-00006
   Karagiannis J, 2003, J CARDIOVASC PHARM, V42, P497, DOI 10.1097/00005344-200310000-00007
   Kojda G, 1998, Pharm Acta Helv, V73, P27, DOI 10.1016/S0031-6865(97)00044-7
   KOLETSKY S, 1975, AM J PATHOL, V80, P129
   Li HG, 2002, NITRIC OXIDE-BIOL CH, V7, P132, DOI 10.1016/S1089-8603(02)00127-1
   Li HG, 2002, NITRIC OXIDE-BIOL CH, V7, P149, DOI 10.1016/S1089-8603(02)00111-8
   Lteif A, 2004, CAN J CARDIOL, V20, p66B
   Maxwell AJ, 1998, EXP PHYSIOL, V83, P573, DOI 10.1113/expphysiol.1998.sp004139
   McKendrick JD, 1998, BRIT J PHARMACOL, V124, P361, DOI 10.1038/sj.bjp.0701829
   MCNAMEE CJ, 1994, CIRC RES, V74, P1126, DOI 10.1161/01.RES.74.6.1126
   Mollnau H, 2002, CIRC RES, V90, pE58, DOI 10.1161/01.RES.0000012569.55432.02
   Münzel T, 2000, CIRC RES, V86, pE7, DOI 10.1161/01.RES.86.1.e7
   MURAD F, 1986, J CLIN INVEST, V78, P1, DOI 10.1172/JCI112536
   Nangaku M, 2003, J AM SOC NEPHROL, V14, P1212, DOI 10.1097/01.ASN.0000062961.76776.C1
   REAVEN GM, 1993, ANNU REV MED, V44, P121, DOI 10.1146/annurev.med.44.1.121
   Ruetten H, 1999, CIRC RES, V85, P534, DOI 10.1161/01.RES.85.6.534
   Schulz E, 2004, CURR MED CHEM, V11, P1093, DOI 10.2174/0929867043365369
   SEXL V, 1995, PHARMACOLOGY, V50, P238, DOI 10.1159/000139288
   SHIRASAKI Y, 1988, J PHARMACOL EXP THER, V245, P53
   Steinberg HO, 1996, J CLIN INVEST, V97, P2601, DOI 10.1172/JCI118709
   Subramanian R, 2003, EUR J PHARMACOL, V477, P143, DOI 10.1016/j.ejphar.2003.08.003
   Taniyama Y, 2003, HYPERTENSION, V42, P1075, DOI 10.1161/01.HYP.0000100443.09293.4F
   Vaziri ND, 1998, HYPERTENSION, V31, P1248, DOI 10.1161/01.HYP.31.6.1248
   Vecchione C, 2002, DIABETES, V51, P168, DOI 10.2337/diabetes.51.1.168
   Velasque M T, 2001, Int J Exp Diabetes Res, V2, P217, DOI 10.1155/EDR.2001.217
   YAGI K, 1976, BIOCHEM MED METAB B, V15, P212, DOI 10.1016/0006-2944(76)90049-1
   Yamaguchi Y, 2002, FEBS LETT, V512, P218, DOI 10.1016/S0014-5793(02)02263-9
   Zanchi A, 1995, J HYPERTENS, V13, P1463
NR 36
TC 49
Z9 55
U1 0
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
J9 LIFE SCI
JI Life Sci.
PD FEB 9
PY 2006
VL 78
IS 11
BP 1187
EP 1196
DI 10.1016/j.lfs.2005.06.029
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 013IC
UT WOS:000235402000007
PM 16188278
DA 2025-06-11
ER

PT J
AU Oh, EG
   Bang, SY
   Kim, SH
   Hyun, SS
   Chu, SH
   Jeon, JY
   Im, JA
   Lee, JE
   Lee, MK
AF Oh, Eui Geum
   Bang, So Youn
   Kim, Soo Hyun
   Hyun, Sa Saeng
   Chu, Sang Hui
   Jeon, Justin Y.
   Im, Jee Aee
   Lee, Jung Eun
   Lee, Mi Kyung
TI Therapeutic Lifestyle Modification Program Reduces Plasma Levels of the
   Chemokines CRP and MCP-1 in Subjects With Metabolic Syndrome
SO BIOLOGICAL RESEARCH FOR NURSING
LA English
DT Article
DE metabolic syndrome; lifestyle modification; inflammation
ID PULSE-WAVE VELOCITY; ENDOTHELIAL FUNCTION; WEIGHT-LOSS; OXIDATIVE
   STRESS; RISK; CARBOHYDRATE; RESTRICTION; ADIPONECTIN; PROMOTES; ADULTS
AB Objective: The purpose of this study was to examine the effects of a 6-month therapeutic lifestyle modification (TLM) program on chemokines related to oxidative stress, inflammation, endothelial dysfunction, and arterial stiffness in subjects with metabolic syndrome (MetS). Methods: The authors performed a randomized controlled trial, assigning 52 women (mean age 62.7 +/- 9.0 years) with MetS to a TLM intervention group (n = 31) or a control group (n 21). The authors provided the TLM intervention group with health screening, exercise, low-calorie diet, and health education and counseling for 6 months and instructed the control group to maintain their usual lifestyle behaviors. Outcome variables included levels of myeloperoxidase (MPO), oxidized low-density lipoprotein (LDL), adiponectin, leptin, resistin, high-sensitivity C-reactive protein (hs-CRP), interleukin-1 beta, interleukin-6, tumor necrosis factor-alpha (TNF-alpha), CD40L, monocyte chemotactic protein-1 (MCP-1), retinol-binding protein 4 (RBP-4), endothelin-1, and brachial-ankle pulse wave velocity. The authors used generalized estimating equation (GEE) analyses to estimate the effects of the TLM program. Results: After the 6-month TLM program, hs-CRP levels decreased significantly, and MCP-1 levels increased at a significantly slower rate in the TLM group than they did in the control group (all p < .05). Conclusion: These results indicate that a TLM program could be effective for improving patient inflammatory states and may also be effective in preventing cardiovascular complications in subjects with MetS.
C1 [Oh, Eui Geum] Yonsei Univ, Coll Nursing Nursing Policy & Res Inst, Div Clin Nursing Sci Adult Hlth Nursing, Seoul 120752, South Korea.
   [Kim, Soo Hyun] Inha Univ, Dept Nursing, Inchon, South Korea.
   [Hyun, Sa Saeng] Galsan Publ Hlth Care Ctr, Chungbuk, South Korea.
   [Jeon, Justin Y.; Lee, Mi Kyung] Yonsei Univ, Dept Sport & Leisure Studies, Seoul 120752, South Korea.
   [Im, Jee Aee] InToTo Inc, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System; Inha University;
   Yonsei University
RP Oh, EG (corresponding author), Yonsei Univ, Coll Nursing Nursing Policy & Res Inst, Div Clin Nursing Sci Adult Hlth Nursing, 250 Seongsan Ro, Seoul 120752, South Korea.
EM euigeum@yuhs.ac
RI Lee, Jee-Yon/GER-4141-2022
OI CHU, Sang Hui/0000-0001-6877-5599; Lee, Jung Eun/0000-0002-1195-3427;
   Jeon, Justin/0000-0001-7978-4271; Lee, Mi Kyung/0000-0002-9690-4463; Oh,
   Eui Geum/0000-0002-6941-0708
FU Korean Science and Engineering Foundation [R01-2006-000-11333-0]
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: This work was
   supported by the Korean Science and Engineering Foundation
   (R01-2006-000-11333-0).
CR Bahadursingh S, 2009, W INDIAN MED J, V58, P551
   Bahia Luciana, 2006, Clinics, V61, P433, DOI 10.1590/S1807-59322006000500010
   Ballinger GA, 2004, ORGAN RES METHODS, V7, P127, DOI 10.1177/1094428104263672
   Barba C, 2004, LANCET, V363, P157, DOI 10.1016/s0140-6736(03)15268-3
   Bihan H, 2009, DIABETES METAB, V35, P185, DOI 10.1016/j.diabet.2008.11.002
   Churilla James R., 2007, Metabolic Syndrome and Related Disorders, V5, P331, DOI 10.1089/met.2007.0010
   Cornier MA, 2008, ENDOCR REV, V29, P777, DOI 10.1210/er.2008-0024
   DeMarco VG, 2010, CURR HYPERTENS REP, V12, P93, DOI 10.1007/s11906-010-0095-5
   Elloumi M, 2009, ACTA PAEDIATR, V98, P1487, DOI 10.1111/j.1651-2227.2009.01365.x
   *EXP PAN DET EV TR, 2001, NIH PUBL
   Fernández-Riejos P, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/568343
   Ford ES, 2008, DIABETES CARE, V31, P1898, DOI 10.2337/dc08-0423
   Goldberg Y, 2009, CLIN NUTR, V28, P21, DOI 10.1016/j.clnu.2008.10.001
   Hamdy O, 2003, DIABETES CARE, V26, P2119, DOI 10.2337/diacare.26.7.2119
   Hazell LJ, 2001, FREE RADICAL BIO MED, V31, P1254, DOI 10.1016/S0891-5849(01)00717-1
   Heinonen MV, 2009, NUTR METAB CARDIOVAS, V19, P626, DOI 10.1016/j.numecd.2008.12.008
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lim JH, 2009, EXP MOL MED, V41, P757, DOI 10.3858/emm.2009.41.10.082
   Matsushita K, 2006, ARTERIOSCL THROM VAS, V26, P871, DOI 10.1161/01.ATV.0000208363.85388.8f
   Miyatake N, 2010, INTERNAL MED, V49, P261, DOI 10.2169/internalmedicine.49.2900
   Nordmann AJ, 2006, ARCH INTERN MED, V166, P285, DOI 10.1001/archinte.166.3.285
   Oh EG, 2010, METABOLISM, V59, P1035, DOI 10.1016/j.metabol.2009.10.027
   Oh EG, 2008, METABOLISM, V57, P255, DOI 10.1016/j.metabol.2007.09.009
   Ohnishi H, 2003, DIABETES CARE, V26, P437, DOI 10.2337/diacare.26.2.437
   Payne WR, 2008, DIABETES CARE, V31, P2244, DOI 10.2337/dc08-0152
   Raitakari M, 2004, ARTERIOSCL THROM VAS, V24, P124, DOI 10.1161/01.ATV.0000109749.11042.7c
   Rector RS, 2007, AM J PHYSIOL-ENDOC M, V293, pE500, DOI 10.1152/ajpendo.00116.2007
   Roberts CK, 2006, J APPL PHYSIOL, V100, P1657, DOI 10.1152/japplphysiol.01292.2005
   Sell H, 2007, CURR OPIN LIPIDOL, V18, P258, DOI 10.1097/MOL.0b013e3281338546
   Shechter M, 2006, AM J CARDIOL, V97, P1650, DOI 10.1016/j.amjcard.2005.12.059
   Sung KC, 2009, AM J CARDIOL, V103, P1732, DOI 10.1016/j.amjcard.2009.02.027
   Takaki A, 2008, HYPERTENS RES, V31, P1347, DOI 10.1291/hypres.31.1347
   Troseid M, 2004, EUR HEART J, V25, P349, DOI 10.1016/j.ehj.2003.12.006
   Tziomalos K, 2010, NUTR METAB CARDIOVAS, V20, P140, DOI 10.1016/j.numecd.2009.08.006
   Verma S, 2003, CIRCULATION, V108, P736, DOI 10.1161/01.CIR.0000084503.91330.49
   Volek JS, 2009, LIPIDS, V44, P297, DOI 10.1007/s11745-008-3274-2
   Williams IL, 2005, OBES SURG, V15, P1055, DOI 10.1381/0960892054621134
   Wycherley TP, 2008, DIABETES OBES METAB, V10, P1062, DOI 10.1111/j.1463-1326.2008.00863.x
NR 38
TC 23
Z9 25
U1 0
U2 12
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1099-8004
EI 1552-4175
J9 BIOL RES NURS
JI Biol. Res. Nurs.
PD JAN
PY 2013
VL 15
IS 1
BP 48
EP 55
DI 10.1177/1099800411416637
PG 8
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nursing
GA 040OT
UT WOS:000311332900006
PM 21859748
DA 2025-06-11
ER

PT J
AU Singh, RB
   Gupta, S
   Dherange, P
   De Meester, F
   Wilczynska, A
   Alam, SE
   Pella, D
   Wilson, DW
AF Singh, Ram B.
   Gupta, Siddharth
   Dherange, Parinita
   De Meester, Fabien
   Wilczynska, Agnieszka
   Alam, Shaan E.
   Pella, Daniel
   Wilson, Douglas W.
TI Metabolic syndrome: a brain disease
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Review
DE hypothalamus; glucose intolerance; insulin resistance; brain disease;
   diet; nutrition; omega-3 fatty acids; brain development; brain-heart
   connection; Mediterranean diet
ID POLYUNSATURATED FATTY-ACIDS; CORONARY-ARTERY DISEASE; INSULIN-RECEPTOR;
   BLOOD-PRESSURE; ARCUATE NUCLEUS; TNF-ALPHA; RISK-FACTORS; VAGUS NERVE;
   ACETYLCHOLINE; RELEASE
AB Recent research indicates an association between brain dysfunction and the pathogenesis of metabolic syndrome. To investigate this, we created a Medline search (up to December 2011) of articles in PubMed. The results indicated that refined carbohydrates, saturated and total fat, high levels of omega-6 fatty acids, and low levels of omega-3 fatty acids and other long chain polyunsaturated fatty acids (PUFA), all in conjunction with sedentary behaviour and mental stress can predispose to inflammation. Increased sympathetic activity, with increased secretion of catecholamine, cortisol, and serotonin can cause oxidative stress, which may damage the arcuate nucleus as well as the hypothalamus and macrophages, and the liver may release pro-inflammatory cytokines. These, in conjunction with an underlying deficiency in long chain PUFA, may damage the arcuate nucleus as well as neuropeptide-Y and pro-opiomelanocortin neurons and insulin receptors in the brain, especially during fetal life, infancy, and childhood, resulting in their dysfunction. Of the fatty acids in the brain, 30%-50% are long chain PUFA, which are incorporated in the cell membrane phospholipids. Hence, omega-3 fatty acids, which are also known to enhance parasympathetic activity and increase the secretion of anti-inflammatory cytokines interleukin (IL)-4 and IL-10 as well as acetylcholine in the hippocampus, may be protective. Therefore, treatment with omega-3 fatty acids may be applied for the prevention of metabolic syndrome.
C1 [Singh, Ram B.; Gupta, Siddharth; Dherange, Parinita; De Meester, Fabien; Wilczynska, Agnieszka] TsimTsoum Inst, PL-40126 Krakow, Silesia, Poland.
   [Alam, Shaan E.] Univ Coll Med Sci, Delhi 190095, India.
   [Pella, Daniel] PJ Safaric Univ, Interna Klin FNSP, Dept Med 3, Kosice 04011, Slovakia.
   [Wilson, Douglas W.] Sch Med & Hlth, Durham TS17 6BH, England.
C3 University of Delhi; University College of Medical Sciences
RP Singh, RB (corresponding author), TsimTsoum Inst, Golebia St, PL-40126 Krakow, Silesia, Poland.
EM rbs@tsimtsoum.net
OI Gupta, Siddharth/0000-0002-1948-0847; Pella, Daniel/0000-0001-9999-6271
CR Abbott MA, 1999, J NEUROSCI, V19, P7300, DOI 10.1523/JNEUROSCI.19-17-07300.1999
   Achike FI, 2011, CLIN EXP PHARMACOL P, V38, P1, DOI 10.1111/j.1440-1681.2010.05460.x
   Agrawal R, 2012, J PHYSIOL-LONDON, V590, P2485, DOI 10.1113/jphysiol.2012.230078
   [Anonymous], 2003, WHO TECHN REP SER
   Barinaga M, 1998, SCIENCE, V279, P2041, DOI 10.1126/science.279.5359.2041
   BARKER DJP, 1993, DIABETOLOGIA, V36, P62, DOI 10.1007/BF00399095
   Baur LA, 1998, METABOLISM, V47, P106, DOI 10.1016/S0026-0495(98)90202-5
   Beaglehole R, 2011, LANCET, V378, P449, DOI 10.1016/S0140-6736(11)60879-9
   Bhatia HS, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0028451
   Bhopal R, 2002, BRIT MED J, V324, P625, DOI 10.1136/bmj.324.7338.625
   Borovikova LV, 2000, NATURE, V405, P458, DOI 10.1038/35013070
   Brüning JC, 2000, SCIENCE, V289, P2122, DOI 10.1126/science.289.5487.2122
   Casas-Agustench P, 2011, NUTR METAB CARDIOVAS, V21, P126, DOI 10.1016/j.numecd.2009.08.005
   Cone RD, 2001, INT J OBESITY, V25, pS63, DOI 10.1038/sj.ijo.0801913
   Cunnane SC, 2000, LIPIDS, V35, P105, DOI 10.1007/s11745-000-0501-6
   Dickson SL, 2011, MOL CELL ENDOCRINOL, V340, P80, DOI 10.1016/j.mce.2011.02.017
   Dourmap N, 1997, BRAIN RES, V749, P295, DOI 10.1016/S0006-8993(96)01319-4
   Dubnov G., 2008, WORLD HEART J, V1, P49
   Floto RA, 2003, LANCET, V361, P1069, DOI 10.1016/S0140-6736(03)12902-9
   Forsyth JS, 2003, BRIT MED J, V326, P953, DOI 10.1136/bmj.326.7396.953
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Hajnal A, 1998, BRAIN RES, V785, P41, DOI 10.1016/S0006-8993(97)01291-2
   Halberg F, 2008, INT J GERONTO GERIAT, V11, P119
   Halberg F., 2011, WORLD HEART J, V4, P279
   He K, 2006, CIRCULATION, V113, P1675, DOI 10.1161/CIRCULATIONAHA.105.588327
   Heine RJ, 2004, DIABETIC MED, V21, P208, DOI 10.1111/j.1464-5491.2004.01149.x
   Hori T, 1998, NEUROIMMUNOMODULAT, V5, P172, DOI 10.1159/000026334
   Hotamisligil GS, 1999, J INTERN MED, V245, P621, DOI 10.1046/j.1365-2796.1999.00490.x
   Hu FB, 2001, DIABETOLOGIA, V44, P805, DOI 10.1007/s001250100547
   Innis SM, 2004, ADV EXP MED BIOL, V554, P27
   Jobst EE, 2004, TRENDS ENDOCRIN MET, V15, P488, DOI 10.1016/j.tem.2004.10.007
   Jovinge S, 1998, METABOLISM, V47, P113, DOI 10.1016/S0026-0495(98)90203-7
   Koletzko B, 2001, ACTA PAEDIATR, V90, P460, DOI 10.1080/080352501750126492
   KUMAR GS, 1992, NUTR RES, V12, P815, DOI 10.1016/S0271-5317(05)80639-6
   Lauritzen I, 2000, EMBO J, V19, P1784, DOI 10.1093/emboj/19.8.1784
   Lawrence JM, 2004, DIABETES CARE, V27, P41, DOI 10.2337/diacare.27.1.41
   Liese AD, 2003, AM J CLIN NUTR, V78, P965, DOI 10.1093/ajcn/78.5.965
   Mattson MP, 2001, J CLIN INVEST, V107, P247, DOI 10.1172/JCI11916
   McKeown NM, 2004, DIABETES CARE, V27, P538, DOI 10.2337/diacare.27.2.538
   McNay DEG, 2012, J CLIN INVEST, V122, P142, DOI 10.1172/JCI43134
   Mechirova V., 2009, WORLD HEART J, V1, P137
   Minami M, 1997, PHARMACOL BIOCHEM BE, V58, P1123, DOI 10.1016/S0091-3057(97)00300-6
   Möhlig M, 2004, J CLIN ENDOCR METAB, V89, P1885, DOI 10.1210/jc.2003-031101
   NILSSON L, 1988, NEUROSCI LETT, V88, P221, DOI 10.1016/0304-3940(88)90130-9
   Nobukata H, 2000, METABOLISM, V49, P912, DOI 10.1053/meta.2000.6739
   Ohtani N, 1997, J NEUROCHEM, V69, P1622
   Pella D, 2003, LANCET, V361, P79, DOI 10.1016/S0140-6736(03)12139-3
   Pella D., 2011, OPEN NUTRACEUTICALS, V4, P107, DOI [10.2174/1876396001104010107, DOI 10.2174/1876396001104010107]
   Perez-Tilve D, 2010, NAT NEUROSCI, V13, P877, DOI 10.1038/nn.2569
   Poppitt SD, 2010, PHYSIOL BEHAV, V101, P161, DOI 10.1016/j.physbeh.2010.04.036
   Ragozzino ME, 1996, P NATL ACAD SCI USA, V93, P4693, DOI 10.1073/pnas.93.10.4693
   Ravelli ACJ, 2000, ARCH DIS CHILD, V82, P248, DOI 10.1136/adc.82.3.248
   Rumawas ME, 2009, AM J CLIN NUTR, V90, P1608, DOI 10.3945/ajcn.2009.27908
   SAHU A, 1995, ENDOCRINOLOGY, V136, P5718, DOI 10.1210/en.136.12.5718
   Salem N, 1996, P NATL ACAD SCI USA, V93, P49, DOI 10.1073/pnas.93.1.49
   Salmerón J, 2001, AM J CLIN NUTR, V73, P1019
   Sawada T, 2010, EUR J CLIN NUTR, V64, P331, DOI 10.1038/ejcn.2009.158
   Schulze MB, 2004, DIABETES CARE, V27, P613, DOI 10.2337/diacare.27.2.613
   Schwartz MW, 2005, SCIENCE, V307, P375, DOI 10.1126/science.1104344
   Simopoulos AP, 2002, ASIA PAC J CLIN NUTR, V11, pS117, DOI 10.1046/j.1440-6047.11.s6.3.x
   Simopoulos AP, 2003, WORLD REV NUTR DIET, V92, P1
   Simopoulos AP, 2001, WORLD REV NUTR DIET, V89, P1
   Singh R. B., 2001, Journal of Nutritional and Environmental Medicine (Abingdon), V11, P43, DOI 10.1080/13590840020030258
   Singh R. B., 2009, WORLD HEART J, V1, P219
   Singh R.B., 2009, WORLD HEART J, V1, P307
   Singh R B., 2004, J. Nutr. Environ. Med, V14, P3, DOI DOI 10.1080/13590840410001695220
   Singh RB, 1997, CARDIOVASC DRUG THER, V11, P485, DOI 10.1023/A:1007757724505
   Singh RB, 1997, CORONARY ARTERY DIS, V8, P463, DOI 10.1097/00019501-199707000-00009
   Singh RB, 2004, BIOMED PHARMACOTHER, V58, pS56, DOI 10.1016/S0753-3322(04)80011-8
   Singh RB, 1999, INT J CARDIOL, V69, P139, DOI 10.1016/S0167-5273(99)00010-8
   Singh RB, 2002, LANCET, V360, P1455, DOI 10.1016/S0140-6736(02)11472-3
   Singh RB, 2009, OPEN NUTRA J, V2, P42, DOI DOI 10.2174/1876396000902010042
   Sternson SM, 2005, NAT NEUROSCI, V8, P1356, DOI 10.1038/nn1550
   Strik CM, 2010, NUTR J, V9, DOI 10.1186/1475-2891-9-24
   TAKAHASHI A, 1994, J AUTONOM NERV SYST, V48, P213, DOI 10.1016/0165-1838(94)90050-7
   Tanebe K, 2000, J NEUROENDOCRINOL, V12, P13
   Thomas GN, 2000, AM J HYPERTENS, V13, P745, DOI 10.1016/S0895-7061(00)00265-X
   van den Top M, 2004, NAT NEUROSCI, V7, P493, DOI 10.1038/nn1226
   Varela L, 2011, J MOL ENDOCRINOL, V46, pR43, DOI 10.1677/JME-10-0068
   Venters HD, 2000, TRENDS NEUROSCI, V23, P175, DOI 10.1016/S0166-2236(99)01533-7
   Wan Q, 1997, NATURE, V388, P686, DOI 10.1038/41792
   Wang H, 2003, NATURE, V421, P384, DOI 10.1038/nature01339
   WHO Study Group, 1990, DIET NUTR PREV CHRON
   World Health Organization, 2005, WHO GEN NONC DIS
   Xu ZM, 1996, ANESTHESIOLOGY, V85, P107, DOI 10.1097/00000542-199607000-00015
   Zhou L, 2007, CELL METAB, V6, P398, DOI 10.1016/j.cmet.2007.10.008
NR 86
TC 43
Z9 46
U1 0
U2 37
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD SEP
PY 2012
VL 90
IS 9
BP 1171
EP 1183
DI 10.1139/Y2012-122
PG 13
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 997GI
UT WOS:000308152200004
PM 22913633
DA 2025-06-11
ER

PT J
AU Tirosh, A
   Garg, R
   Adler, GK
AF Tirosh, Amir
   Garg, Rajesh
   Adler, Gail K.
TI Mineralocorticoid Receptor Antagonists and the Metabolic Syndrome
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
DE Aldosterone; Mineralocorticoid receptor; Obesity; Insulin resistance;
   Spironolactone; Eplerenone
ID ANGIOTENSIN-ALDOSTERONE SYSTEM; CHRONIC KIDNEY-DISEASE;
   INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; GLUCOSE; SPIRONOLACTONE;
   DYSFUNCTION; EPLERENONE; ADIPONECTIN; SENSITIVITY
AB Key components of the metabolic syndrome (MetS), ie, obesity and insulin resistance, are associated with increased aldosterone production and mineralocorticoid receptor (MR) activation. Both MetS and hyperaldosteronism are proinflammatory and pro-oxidative states associated with cardiovascular disease. This review discusses emerging data that MR activation may contribute to abnormalities seen in MetS. In view of these data, MR antagonists may be beneficial in MetS, not only by controlling hypertension but also by reversing inflammation, oxidative stress, and defective insulin signaling at the cellular-molecular level. Clinical trials have demonstrated benefits of MR antagonists in heart failure, hypertension, and diabetic nephropathy, but additional trials are needed to demonstrate the clinical significance of MR blockade in MetS.
C1 [Tirosh, Amir; Garg, Rajesh; Adler, Gail K.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Endocrinol Diabet & Hypertens, Boston, MA 02115 USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Brigham & Women's Hospital
RP Adler, GK (corresponding author), Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Endocrinol Diabet & Hypertens, 221 Longwood Ave, Boston, MA 02115 USA.
EM atirosh@partners.org; rgarg@partners.org; gadler@partners.org
OI Garg, Rajesh/0000-0002-7779-1619; Tirosh, Amir/0000-0003-2210-5906;
   Adler, Gail/0000-0003-3506-7347
FU National Institutes of Health [R01HL 087060]
FX This work is supported in part by a grant from the National Institutes
   of Health, R01HL 087060 (GKA and RG).
CR Bentley-Lewis R, 2007, J CLIN ENDOCR METAB, V92, P4472, DOI 10.1210/jc.2007-1088
   Brown NJ, 2008, HYPERTENSION, V51, P161, DOI 10.1161/HYPERTENSIONAHA.107.095489
   Calle C, 2003, J STEROID BIOCHEM, V84, P543, DOI 10.1016/S0960-0760(03)00072-4
   Caprio M, 2008, CIRC RES, V102, P1359, DOI 10.1161/CIRCRESAHA.108.174235
   Caprio M, 2007, FASEB J, V21, P2185, DOI 10.1096/fj.06-7970com
   CATENA C, 2010, HORM METAB RES  0129
   Catena C, 2006, J CLIN ENDOCR METAB, V91, P3457, DOI 10.1210/jc.2006-0736
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Edwards NC, 2009, J AM COLL CARDIOL, V54, P505, DOI 10.1016/j.jacc.2009.03.066
   Ehrhart-Bornstein M, 2003, P NATL ACAD SCI USA, V100, P14211, DOI 10.1073/pnas.2336140100
   Engeli S, 2005, HYPERTENSION, V45, P356, DOI 10.1161/01.HYP.0000154361.47683.d3
   Fallo F, 2007, AM J HYPERTENS, V20, P855, DOI 10.1016/j.amjhyper.2007.03.012
   FERRANNINI E, 1994, J CARDIOVASC PHARM, V24, pS61
   Freel EM, 2009, HEART, V95, P1920, DOI 10.1136/hrt.2009.173344
   Funder JW, 2009, HYPERTENSION, V53, P286, DOI 10.1161/HYPERTENSIONAHA.108.119966
   Gaddam KK, 2009, CURR PROB CARDIOLOGY, V34, P51, DOI 10.1016/j.cpcardiol.2008.10.002
   Garg R, 2010, J CLIN ENDOCR METAB, V95, P1986, DOI 10.1210/jc.2009-2521
   Giacchetti G, 2005, TRENDS ENDOCRIN MET, V16, P120, DOI 10.1016/j.tem.2005.02.003
   Goodfriend TL, 1999, PROSTAG LEUKOTR ESS, V60, P401, DOI 10.1016/S0952-3278(99)80020-9
   Grandi AM, 2002, HYPERTENSION, V40, P647, DOI 10.1161/01.HYP.0000036399.80194.D8
   Grossmann C, 2009, MOL CELL ENDOCRINOL, V308, P53, DOI 10.1016/j.mce.2009.02.005
   Guo C, 2008, CIRCULATION, V117, P2253, DOI 10.1161/CIRCULATIONAHA.107.748640
   Hirata A, 2009, CARDIOVASC RES, V84, P164, DOI 10.1093/cvr/cvp191
   Izawa H, 2005, CIRCULATION, V112, P2940, DOI 10.1161/CIRCULATIONAHA.105.571653
   Joffe HV, 2007, J CLIN ENDOCR METAB, V92, P2552, DOI 10.1210/jc.2007-0393
   Kirilmaz B, 2010, J CLIN HYPERTENS, V12, P136, DOI 10.1111/j.1751-7176.2009.00229.x
   Lamounier-Zepter V, 2005, BEST PRACT RES CL EN, V19, P567, DOI 10.1016/j.beem.2005.07.002
   Lemarié CA, 2009, CIRC RES, V105, P852, DOI 10.1161/CIRCRESAHA.109.196576
   Leopold JA, 2007, NAT MED, V13, P189, DOI 10.1038/nm1545
   Limor R, 2009, J CELL BIOCHEM, V108, P1203, DOI 10.1002/jcb.22352
   Matrozova J, 2009, HYPERTENSION, V53, P605, DOI 10.1161/HYPERTENSIONAHA.108.122002
   McMurray JJ, 2010, NEW ENGL J MED, V362, P1477, DOI 10.1056/NEJMoa1001121
   McNeill AM, 2005, DIABETES CARE, V28, P385, DOI 10.2337/diacare.28.2.385
   Mehdi UF, 2009, J AM SOC NEPHROL, V20, P2641, DOI 10.1681/ASN.2009070737
   Ndisang JF, 2009, ENDOCRINOLOGY, V150, P2098, DOI 10.1210/en.2008-0239
   Odermatt A, 2009, STEROIDS, V74, P163, DOI 10.1016/j.steroids.2008.10.010
   PIERLUISSI J, 1986, DIABETOLOGIA, V29, P119, DOI 10.1007/BF00456122
   Pitt B, 2003, NEW ENGL J MED, V348, P1309, DOI 10.1056/NEJMoa030207
   Pitt B, 2003, CIRCULATION, V108, P1831, DOI 10.1161/01.CIR.0000091405.00772.6E
   Pitt B, 1999, NEW ENGL J MED, V341, P709, DOI 10.1056/NEJM199909023411001
   SATO A, 2009, J HUM HYPERTENS 1029
   Selvaraj J, 2009, CLIN CHIM ACTA, V407, P51, DOI 10.1016/j.cca.2009.06.030
   Shibata S, 2008, NAT MED, V14, P1370, DOI 10.1038/nm.1879
   Sindelka G, 2000, EXP CLIN ENDOCR DIAB, V108, P21
   Wada T, 2010, ENDOCRINOLOGY, V151, P2040, DOI 10.1210/en.2009-0869
   Wada T, 2009, ENDOCRINOLOGY, V150, P1662, DOI 10.1210/en.2008-1018
   Wang JJ, 2007, EUR HEART J, V28, P857, DOI 10.1093/eurheartj/ehl524
   Wang JJ, 2010, ATHEROSCLEROSIS, V210, P237, DOI 10.1016/j.atherosclerosis.2009.10.042
   Wannamethee SG, 2005, ARCH INTERN MED, V165, P2644, DOI 10.1001/archinte.165.22.2644
   Wilson PWF, 2005, CIRCULATION, V112, P3066, DOI 10.1161/CIRCULATIONAHA.105.539528
NR 50
TC 57
Z9 64
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD AUG
PY 2010
VL 12
IS 4
BP 252
EP 257
DI 10.1007/s11906-010-0126-2
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 669LZ
UT WOS:000283353600007
PM 20563672
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Shatylo, V
   Antoniuk-Shcheglova, I
   Naskalova, S
   Bondarenko, O
   Havalko, A
   Krasnienkov, D
   Zabuga, O
   Kukharskyy, V
   Guryanov, V
   Vaiserman, A
AF Shatylo, Valerii
   Antoniuk-Shcheglova, Ivanna
   Naskalova, Svitlana
   Bondarenko, Olena
   Havalko, Anna
   Krasnienkov, Dmytro
   Zabuga, Oksana
   Kukharskyy, Vitaliy
   Guryanov, Vitaly
   Vaiserman, Alexander
TI Cardio-metabolic benefits of quercetin in elderly patients with
   metabolic syndrome
SO PHARMANUTRITION
LA English
DT Article
DE Quercetin; Phyto-bioactive compound; Antioxidant; Metabolic syndrome;
   Lipid profile; Glycemic control
ID BLOOD-PRESSURE; DOUBLE-BLIND; INFLAMMATION; EPICATECHIN; STRESS; ADULTS
AB Background: Quercetin is regarded as a promising phytochemical in treating metabolic syndrome (MetS).
   Methods: Present study is a randomized, placebo-controlled, double-blind clinical trial aimed at evaluating effects of quercetin on different aspects of MetS in patients aged 60 + . Study participants consumed two quercetincontaining or placebo tablets 3 times per day (daily dose = 240 mg) during 3 months.
   Results: Quercetin administration decreased body weight (-0.32 kg; p = 0.007) and body mass index (-0.12 kg/ m(2); p = 0.01). The blood pressure was also decreased: systolic blood pressure: -7.7 mm Hg (p < 0.001), diastolic blood pressure: -4.1 mm Hg (p = 0.001) relative to baseline values; these effects remained statistically significant after controlling for age, sex and body mass index. Quercetin intervention also improved cholesterol metabolism (serum total cholesterol: -0.44 mmol/L; p = 0.003; low-density lipoprotein cholesterol: -0.41 mmol/L; p = 0.007) and decreased fasting plasma insulin (-2.01 mu U/mL; p = 0.02) and glucose level at 2-hour oral glucose tolerance test (-0.78 mmol/L; p = 0.004). Telomere length and markers of oxidative stress were mostly unchanged except for glutathione level which was significantly decreased (-0.24 mu M/L; p = 0.005) in the quercetin-treated group.
   Conclusion: These findings indicate that quercetin may be effective in treating MetS. This trial was registered by Ukrainian Registry of Clinical Trials on October 30, 2017 (registration No1339).
C1 [Shatylo, Valerii; Antoniuk-Shcheglova, Ivanna; Naskalova, Svitlana; Bondarenko, Olena; Havalko, Anna; Krasnienkov, Dmytro; Zabuga, Oksana; Kukharskyy, Vitaliy; Vaiserman, Alexander] NAMS Ukraine, DF Chebotarev State Inst Gerontol, UA-04114 Kiev, Ukraine.
   [Guryanov, Vitaly] Bogomolets Natl Med Univ, UA-02000 Kiev, Ukraine.
C3 National Academy of Medical Sciences of Ukraine; D. F. Chebotarev
   Institute of Gerontology of the National Academy of Medical Sciences of
   Ukraine; Bogomolets National Medical University
RP Vaiserman, A (corresponding author), Inst Gerontol, Vyshgorodskaya St 67, UA-04114 Kiev, Ukraine.
EM vaiserman@geront.kiev.ua
RI Бондаренко, Олена/GRF-6169-2022; Gurianov, Vitaliy/LWK-2758-2024;
   Antoniuk-Shcheglova, Ivanna/JTS-3444-2023; Naskalova,
   Svitlana/JTS-3732-2023; Shatylo, Valeriy/JXY-3176-2024
OI Naskalova, Svitlana/0000-0001-9518-2633; Shatylo,
   Valeriy/0000-0001-7114-9150; Gurianov, Vitaly/0000-0001-8509-6301;
   Zabuha, Oksana/0000-0001-8400-185X
FU National Academy of Medical Sciences of Ukraine [0117U001419]
FX This research was realized with the support of the National Academy of
   Medical Sciences of Ukraine, the state registration number 0117U001419.
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Cawthon RM, 2009, NUCLEIC ACIDS RES, V37, DOI 10.1093/nar/gkn1027
   Corrêa RCG, 2018, CRIT REV FOOD SCI, V58, P942, DOI 10.1080/10408398.2016.1233860
   Das BK, 1998, INVEST OPHTH VIS SCI, V39, P2058
   Deng Q, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/5926381
   Dower JI, 2015, J NUTR, V145, P1459, DOI 10.3945/jn.115.211888
   Edwards RL, 2007, J NUTR, V137, P2405, DOI 10.1093/jn/137.11.2405
   Egert S, 2009, BRIT J NUTR, V102, P1065, DOI 10.1017/S0007114509359127
   Farzaei MH, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20194957
   Faul F, 2007, BEHAV RES METHODS, V39, P175, DOI 10.3758/BF03193146
   Ferenczyova K, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21051585
   GOTH L, 1991, CLIN CHIM ACTA, V196, P143, DOI 10.1016/0009-8981(91)90067-M
   GREIDER CW, 1985, CELL, V43, P405, DOI 10.1016/0092-8674(85)90170-9
   Gormaz JG, 2015, CURR TOP MED CHEM, V15, P1735, DOI 10.2174/1568026615666150427124357
   Guo WF, 2019, CURR PHARM DESIGN, V25, P3087, DOI 10.2174/1381612825666190829153552
   Khosravi Alireza, 2017, Adv Biomed Res, V6, P121, DOI 10.4103/abr.abr_249_16
   Kirkland JL, 2020, J INTERN MED, V288, P518, DOI 10.1111/joim.13141
   Koliada AK, 2015, FRONT GENET, V6, DOI 10.3389/fgene.2015.00082
   KOSTYUK VA, 1989, BIOCHEM INT, V19, P1117
   Larson AJ, 2012, ADV NUTR, V3, P39, DOI 10.3945/an.111.001271
   Li Y, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030167
   Martel J, 2019, MED RES REV, V39, P1515, DOI 10.1002/med.21559
   Mirsafaei L, 2020, PLANT FOOD HUM NUTR, V75, P307, DOI 10.1007/s11130-020-00832-0
   MOKRASCH LC, 1984, ANAL BIOCHEM, V140, P506, DOI 10.1016/0003-2697(84)90201-X
   Monserrat-Mesquida M, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9030236
   Na L., 2020, BRIT J NUTR, P1
   Ossola B, 2009, EXPERT OPIN DRUG SAF, V8, P397, DOI 10.1517/14740330903026944
   Payab M, 2020, PHYTOTHER RES, V34, P526, DOI 10.1002/ptr.6547
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Saisho Y, 2015, ENDOCR METAB IMMUNE, V15, P196, DOI 10.2174/1871530315666150316124019
   Salehi B, 2020, ACS OMEGA, V5, P11849, DOI 10.1021/acsomega.0c01818
   Schlenke P, 1998, CLIN DIAGN LAB IMMUN, V5, P808, DOI 10.1128/CDLI.5.6.808-813.1998
   Tabrizi R, 2020, CRIT REV FOOD SCI, V60, P1855, DOI 10.1080/10408398.2019.1604491
   Tamtaji OR, 2019, CURR PHARM DESIGN, V25, P1372, DOI 10.2174/1381612825666190513095352
   Ulusoy HG, 2020, CRIT REV FOOD SCI, V60, P3290, DOI 10.1080/10408398.2019.1683810
   Van den Eynde MDG, 2018, J NUTR, V148, P1911, DOI 10.1093/jn/nxy236
   Welty FK, 2016, TRANSL RES, V167, P257, DOI 10.1016/j.trsl.2015.06.017
   Xu D, 2019, MOLECULES, V24, DOI 10.3390/molecules24061123
   Zahedi M, 2013, INT J PREVENTIVE MED, V4, P777
NR 39
TC 13
Z9 14
U1 1
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-4344
J9 PHARMANUTRITION
JI PharmaNutrition
PD MAR
PY 2021
VL 15
AR 100250
DI 10.1016/j.phanu.2020.100250
EA JAN 2021
PG 7
WC Chemistry, Medicinal; Geriatrics & Gerontology; Gerontology; Nutrition &
   Dietetics; Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy; Geriatrics & Gerontology; Nutrition & Dietetics
GA SG4XK
UT WOS:000653444400002
DA 2025-06-11
ER

PT J
AU Rosenson, RS
AF Rosenson, Robert S.
TI Treatment of Hypertension in Metabolic Syndrome Subjects with Amlodipine
   and Olmesartan-Effects on Oxidized Non-Esterified Free Fatty Acids and
   Cytokine Production
SO CARDIOVASCULAR DRUGS AND THERAPY
LA English
DT Article
DE Hypertension; Oxidative stress; Calcium channel blockers; Angiotensin
   receptor antagonists
ID DENSITY-LIPOPROTEIN OXIDATION; CONVERTING ENZYME-INHIBITOR;
   ATHEROSCLEROSIS; ANTAGONIST; EXPRESSION; LOSARTAN; MONKEYS; MUSCLE; DIET
AB Angiotensin II increases activation of oxidative signaling and vascular inflammatory gene expression, and interruption of the renin-angiotensin system has been considered more vasculoprotective than use of calcium channel antagonists and other anti-hypertensive therapies. Despite these putative mechanisms, amlodipine is equally efficacious as other therapies in reducing cardiovascular events.
   Double-blind, controlled trial, designed to investigate the effects of 2-months treatment with amlodipine and olmesartan on oxidized non-esterified fatty acids (ox-NEFA), and lipopolysaccharide-stimulated cytokine production in whole blood among 23 hypertensive subjects with the metabolic syndrome.
   Treatment with olmesartan was no different than amlodipine in changing concentrations of total oxidized fatty acids (p = 0.37), total ox-NEFA (p = 0.43) and 9, 10, 11, 12, 13, 14, 15 and 16 ox-NEFA concentrations. In contrast, 8 ox-NEFA increased (median [interquartile ranges] by 45.2% [5.3 to 50.0] in olmesartan-treated subjects) compared with a decrease of 18.4% (-45.1-13.9) in amlodipine-treated subjects (p = 0.03). Lipopolysaccharide-stimulated cytokine production and levels of soluble cellular adhesion molecules did not change with either treatment.
   Despite experimental data that demonstrates that angiotensin receptor antagonists reduce cellular oxidant stress and inflammation, olmesartan was not different than amlodipine in changing ox-NEFA and inflammatory markers in hypertensive subjects with the metabolic syndrome.
C1 [Rosenson, Robert S.] SUNY Downstate, Div Endocrinol Diabet & Metab, Dept Med, Brooklyn, NY 11203 USA.
   [Rosenson, Robert S.] SUNY Downstate, Div Cardiovasc Med, Dept Med, Brooklyn, NY 11203 USA.
C3 State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University; State University of New York (SUNY) System; SUNY
   Downstate Health Sciences University
RP Rosenson, RS (corresponding author), SUNY Downstate, Div Endocrinol Diabet & Metab, Dept Med, 450 Clarkson Ave,Box 1205, Brooklyn, NY 11203 USA.
EM robert.rosenson@downstate.edu
RI Rosenson, Robert/MDS-6957-2025
FU Sankyo Pharma (Parsippany, NJ USA)
FX This study was supported by a research grant from Sankyo Pharma
   (Parsippany, NJ USA).
CR Chan H., 1987, AUTOXIDATION UNSATUR
   Dalla Libera L, 2001, CIRCULATION, V103, P2195
   De Keulenaer GW, 1998, BIOCHEM J, V329, P653
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hayek T, 1999, CARDIOVASC RES, V44, P579, DOI 10.1016/S0008-6363(99)00239-4
   Hernández-Presa MA, 1998, AM J PATHOL, V153, P1825, DOI 10.1016/S0002-9440(10)65697-0
   Hope S, 1999, AM J HYPERTENS, V12, P28, DOI 10.1016/S0895-7061(98)00203-9
   Kaikkonen J, 2004, SCAND J CLIN LAB INV, V64, P457, DOI 10.1080/00365510410006667
   Miyazaki M, 1999, BRIT J PHARMACOL, V128, P523, DOI 10.1038/sj.bjp.0702833
   Rosenson RS, 2005, J LAB CLIN MED, V145, P83, DOI 10.1016/j.lab.2004.11.012
   Sobal G, 2001, BIOCHEM PHARMACOL, V61, P373, DOI 10.1016/S0006-2952(00)00548-7
   Strawn WB, 2000, CIRCULATION, V101, P1586, DOI 10.1161/01.CIR.101.13.1586
   Toba H, 2006, HYPERTENS RES, V29, P105, DOI 10.1291/hypres.29.105
   Yoshida H, 1995, Hypertens Res, V18, P47, DOI 10.1291/hypres.18.47
NR 14
TC 4
Z9 4
U1 0
U2 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0920-3206
J9 CARDIOVASC DRUG THER
JI Cardiovasc. Drugs Ther.
PD AUG
PY 2009
VL 23
IS 4
BP 289
EP 294
DI 10.1007/s10557-009-6185-4
PG 6
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 486GM
UT WOS:000269184200005
PM 19641984
DA 2025-06-11
ER

PT B
AU Kyrou, I
   Valsamakis, G
   Tsigos, C
AF Kyrou, Ioannis
   Valsamakis, George
   Tsigos, Constantine
BE Chrousos, GP
   Tsigos, C
TI The endocannabinoid system as a target for the treatment of visceral
   obesity and metabolic syndrome
SO STRESS, OBESITY, AND METABOLIC SYNDROME
SE Annals of the New York Academy of Sciences-Series
LA English
DT Article; Proceedings Paper
CT Bjorntorp Symposium on Stress, Obesity, and Metabolic Syndrome
CY APR 09-10, 2005
CL Athens, GREECE
SP Roche Hellas, Abbott Hellas, Pfizer Hellas, Sanofi Aventis Hellas, GlaxoSmithKline Hellas
DE endocannabinoids; cannabinoid receptors; obesity; metabolic syndrome;
   stress; cannabinoid receptor antagonists; rimonabant in obesity (RIO)
   studies
ID CANNABINOID CB1 RECEPTOR; CENTRAL-NERVOUS-SYSTEM; MESSENGER-RNA LEVELS;
   RAT CAUDATE-PUTAMEN; SIGNAL-TRANSDUCTION; RISK-FACTORS; MOLECULAR
   CHARACTERIZATION; ENDOGENOUS CANNABINOIDS; MONOGLYCERIDE LIPASE;
   ANTAGONIST SR141716
AB The endogenous cannabinoid system is a novel, remarkably elaborate physiological signaling system, comprising the recently identified endogenous cannabinoid ligands, their corresponding selective receptors, and the machinery of proteins and enzymes that is involved in their biosynthesis, release, transport, and degradation. This system extends widely in both the central nervous system (CNS) and the periphery and exhibits a variety of actions implicated in vital functions (e.g., behavioral, antinociceptive, neuroprotective, immunosuppressive, cardiovascular, and metabolic). Particular interest has been focused on the apparent participation of endocannabinoids in metabolic homeostasis by modulating the activity of CNS circuits that control food intake and energy expenditure, the neuroendocrine response of the stress system, and the metabolic functions of crucial peripheral tissues, such as the adipose tissue, the gastrointestinal tract, the liver, and the skeletal muscles. These effects are predominantly CB1 receptor mediated and, thus, selective antagonists of this receptor subtype are being vigorously investigated as potential therapeutic agents for the treatment of various metabolic derangements (e.g., obesity, insulin resistance, dyslipidemia, and metabolic syndrome). The first selective CB1 receptor antagonist, rimonabant, has already successfully completed phase III clinical trials as adjunctive obesity treatment, with significant improvements in several associated metabolic and cardiovascular risk factors that led to the recent approval of its clinical use by the Food and Drug Administration.
C1 Univ Athens, Sch Med, Evgenid Hosp, Endocrinol Metab & Diabet Unit, GR-11528 Athens, Greece.
   Hellen Natl Diabet Ctr, GR-10675 Athens, Greece.
C3 Athens Medical School; National & Kapodistrian University of Athens
RP Tsigos, C (corresponding author), 82 Vas Sophias Ave, GR-11528 Athens, Greece.
EM ctsigos@gmail.com
CR [Anonymous], HDB STRESS MED HLTH
   Beltramo M, 1997, SCIENCE, V277, P1094, DOI 10.1126/science.277.5329.1094
   Beltramo M, 2000, NEUROREPORT, V11, P1231, DOI 10.1097/00001756-200004270-00018
   Bensaid M, 2003, MOL PHARMACOL, V63, P908, DOI 10.1124/mol.63.4.908
   Berridge KC, 1998, BRAIN RES REV, V28, P309, DOI 10.1016/S0165-0173(98)00019-8
   Bisogno T, 2001, EUR J BIOCHEM, V268, P1982, DOI 10.1046/j.1432-1327.2001.02072.x
   BOUABOULA M, 1995, BIOCHEM J, V312, P637, DOI 10.1042/bj3120637
   Breivogel CS, 2001, MOL PHARMACOL, V60, P155, DOI 10.1124/mol.60.1.155
   Breivogel CS, 1998, NEUROBIOL DIS, V5, P417, DOI 10.1006/nbdi.1998.0229
   Cadas H, 1996, J NEUROSCI, V16, P3934
   Charmandari E, 2005, ANNU REV PHYSIOL, V67, P259, DOI 10.1146/annurev.physiol.67.040403.120816
   Childers SR, 1996, BIOCHEM PHARMACOL, V52, P819, DOI 10.1016/0006-2952(96)00419-4
   Christie MJ, 2001, NATURE, V410, P527, DOI 10.1038/35069167
   Costa B, 2000, EUR J PHARMACOL, V395, P1, DOI 10.1016/S0014-2999(00)00170-9
   Cota D, 2003, J CLIN INVEST, V112, P423, DOI 10.1172/JCI17725
   Cota D, 2003, INT J OBESITY, V27, P289, DOI 10.1038/sj.ijo.0802250
   Cravatt BF, 1996, NATURE, V384, P83, DOI 10.1038/384083a0
   Cravatt BF, 2001, P NATL ACAD SCI USA, V98, P9371, DOI 10.1073/pnas.161191698
   De Petrocellis L, 1999, NEUROSCIENCE, V92, P377, DOI 10.1016/S0306-4522(98)00749-0
   De Petrocellis L, 2004, BRIT J PHARMACOL, V141, P765, DOI 10.1038/sj.bjp.0705666
   Derkinderen P, 1996, SCIENCE, V273, P1719, DOI 10.1126/science.273.5282.1719
   Despres JP, 2005, NEW ENGL J MED, V353, P2121, DOI 10.1056/NEJMoa044537
   DEVANE WA, 1988, MOL PHARMACOL, V34, P605
   DEVANE WA, 1992, SCIENCE, V258, P1946, DOI 10.1126/science.1470919
   Di Marzo V, 2001, NATURE, V410, P822, DOI 10.1038/35071088
   Díaz-Laviada I, 2005, MINI-REV MED CHEM, V5, P619, DOI 10.2174/1389557054368808
   DIMARZO V, 1994, NATURE, V372, P686, DOI 10.1038/372686a0
   Dinh TP, 2002, P NATL ACAD SCI USA, V99, P10819, DOI 10.1073/pnas.152334899
   Dinh TP, 2002, CHEM PHYS LIPIDS, V121, P149, DOI 10.1016/S0009-3084(02)00150-0
   Egertová M, 2000, J COMP NEUROL, V422, P159, DOI 10.1002/(SICI)1096-9861(20000626)422:2<159::AID-CNE1>3.0.CO;2-1
   Engeli S, 2005, DIABETES, V54, P2838, DOI 10.2337/diabetes.54.10.2838
   Felder CC, 1996, FEBS LETT, V393, P231, DOI 10.1016/0014-5793(96)00891-5
   FELDER CC, 1995, MOL PHARMACOL, V48, P443
   FELDER CC, 1993, P NATL ACAD SCI USA, V90, P7656, DOI 10.1073/pnas.90.16.7656
   Fride E, 2002, PROSTAG LEUKOTR ESS, V66, P221, DOI 10.1054/plef.2001.0360
   Fride E, 2001, EUR J PHARMACOL, V419, P207, DOI 10.1016/S0014-2999(01)00953-0
   Fride E, 2005, CNS NEUROL DISORD-DR, V4, P633, DOI 10.2174/156800705774933069
   Gabbay E, 2005, LIVER INT, V25, P921, DOI 10.1111/j.1478-3231.2005.01180.x
   GALIEGUE S, 1995, EUR J BIOCHEM, V232, P54, DOI 10.1111/j.1432-1033.1995.tb20780.x
   Gallate JE, 1999, PSYCHOPHARMACOLOGY, V142, P302, DOI 10.1007/s002130050893
   GAONI Y, 1964, J AM CHEM SOC, V86, P1646, DOI 10.1021/ja01062a046
   Garcia DE, 1998, J NEUROSCI, V18, P2834
   Gardner EL, 2005, PHARMACOL BIOCHEM BE, V81, P263, DOI 10.1016/j.pbb.2005.01.032
   Gardner EL, 1998, NEUROBIOL DIS, V5, P502, DOI 10.1006/nbdi.1998.0219
   GERARD CM, 1991, BIOCHEM J, V279, P129, DOI 10.1042/bj2790129
   Giuffrida A, 2001, J PHARMACOL EXP THER, V298, P7
   GOMEZ DP, 2000, BIOCHEM J, V347, P369
   Gómez R, 2002, J NEUROSCI, V22, P9612
   Goparaju SK, 1998, FEBS LETT, V422, P69, DOI 10.1016/S0014-5793(97)01603-7
   Hanus L, 2001, P NATL ACAD SCI USA, V98, P3662, DOI 10.1073/pnas.061029898
   Harrold JA, 2003, BRIT J NUTR, V90, P729, DOI 10.1079/BJN2003942
   Harrold JA, 2002, BRAIN RES, V952, P232, DOI 10.1016/S0006-8993(02)03245-6
   HERKENHAM M, 1991, J NEUROSCI, V11, P563, DOI 10.1523/jneurosci.11-02-00563.1991
   HERKENHAM M, 1990, P NATL ACAD SCI USA, V87, P1932, DOI 10.1073/pnas.87.5.1932
   HERKENHAM M, 1991, BRAIN RES, V547, P267, DOI 10.1016/0006-8993(91)90970-7
   Hermann H, 2002, NEUROSCIENCE, V109, P451, DOI 10.1016/S0306-4522(01)00509-7
   Hildebrandt AL, 2003, EUR J PHARMACOL, V462, P125, DOI 10.1016/S0014-2999(03)01343-8
   Hill MN, 2005, NEUROPSYCHOPHARMACOL, V30, P508, DOI 10.1038/sj.npp.1300601
   Hillard CJ, 1997, J NEUROCHEM, V69, P631, DOI 10.1046/j.1471-4159.1997.69020631.x
   HILLARD CJ, 1995, BBA-LIPID LIPID MET, V1257, P249, DOI 10.1016/0005-2760(95)00087-S
   HOEHE MR, 1991, NEW BIOL, V3, P880
   Howlett AC, 2002, PHARMACOL REV, V54, P161, DOI 10.1124/pr.54.2.161
   Howlett AC, 1998, MOL PHARMACOL, V53, P504, DOI 10.1124/mol.53.3.504
   Howlett AC, 1999, LIFE SCI, V65, P617, DOI 10.1016/S0024-3205(99)00284-2
   Howlett AC, 2000, CHEM PHYS LIPIDS, V108, P53, DOI 10.1016/S0009-3084(00)00187-0
   Hsieh C, 1999, J NEUROCHEM, V73, P493, DOI 10.1046/j.1471-4159.1999.0730493.x
   Huang SM, 2002, P NATL ACAD SCI USA, V99, P8400, DOI 10.1073/pnas.122196999
   Jamshidi N, 2001, BRIT J PHARMACOL, V134, P1151, DOI 10.1038/sj.bjp.0704379
   Kirkham TC, 2005, BEHAV PHARMACOL, V16, P297, DOI 10.1097/00008877-200509000-00004
   Kirkham TC, 2002, BRIT J PHARMACOL, V136, P550, DOI 10.1038/sj.bjp.0704767
   Kirkham TC, 2001, PSYCHOPHARMACOLOGY, V153, P267, DOI 10.1007/s002130000596
   Kirkham Tim C, 2004, Treat Endocrinol, V3, P345, DOI 10.2165/00024677-200403060-00003
   Koerner A, 2005, BEST PRACT RES CL EN, V19, P525, DOI 10.1016/j.beem.2005.07.008
   Kondo JN, 1998, MICROPOR MESOPOR MAT, V21, P429, DOI 10.1016/S1387-1811(98)00004-3
   Lichtman AH, 2002, J PHARMACOL EXP THER, V302, P73, DOI 10.1124/jpet.302.1.73
   Lichtman AH, 2005, J CLIN INVEST, V115, P1130, DOI 10.1172/JCI200525076
   Liu YL, 2005, INT J OBESITY, V29, P183, DOI 10.1038/sj.ijo.0802847
   Lupica CR, 2004, BRIT J PHARMACOL, V143, P227, DOI 10.1038/sj.bjp.0705931
   Maccarrone M, 2004, EUR J BIOCHEM, V271, P4666, DOI 10.1111/j.1432-1033.2004.04427.x
   MACKIE K, 1992, P NATL ACAD SCI USA, V89, P3825, DOI 10.1073/pnas.89.9.3825
   MACKIE K, 1993, MOL PHARMACOL, V44, P498
   Mahmoudian M, 1997, J MOL GRAPH MODEL, V15, P149, DOI 10.1016/S1093-3263(97)00098-3
   MAILLEUX P, 1992, NEUROSCI LETT, V143, P200, DOI 10.1016/0304-3940(92)90265-9
   MAILLEUX P, 1994, EUR J PHARM-MOLEC PH, V266, P193, DOI 10.1016/0922-4106(94)90110-4
   MAILLEUX P, 1993, J NEUROCHEM, V61, P1705, DOI 10.1111/j.1471-4159.1993.tb09807.x
   MAILLEUX P, 1992, NEUROSCIENCE, V48, P655, DOI 10.1016/0306-4522(92)90409-U
   MAILLEUX P, 1993, NEUROSCI LETT, V156, P51, DOI 10.1016/0304-3940(93)90437-P
   MATSUDA LA, 1993, J COMP NEUROL, V327, P535, DOI 10.1002/cne.903270406
   MATSUDA LA, 1990, NATURE, V346, P561, DOI 10.1038/346561a0
   Matsuda LA, 1997, CRIT REV NEUROBIOL, V11, P143, DOI 10.1615/CritRevNeurobiol.v11.i2-3.30
   MECHOULAM R, 1995, BIOCHEM PHARMACOL, V50, P83, DOI 10.1016/0006-2952(95)00109-D
   MINTZ IM, 1995, NEURON, V15, P675, DOI 10.1016/0896-6273(95)90155-8
   MUNRO S, 1993, NATURE, V365, P61, DOI 10.1038/365061a0
   Offertáler L, 2003, MOL PHARMACOL, V63, P699, DOI 10.1124/mol.63.3.699
   Osei-Hyiaman D, 2005, J CLIN INVEST, V115, P1298, DOI 10.1172/JCI200523057
   Pagotto U, 2006, ENDOCR REV, V27, P73, DOI 10.1210/er.2005-0009
   Patel S, 2004, ENDOCRINOLOGY, V145, P5431, DOI 10.1210/en.2004-0638
   Pertwee RG, 1999, CURR MED CHEM, V6, P635
   PETE MJ, 1994, J BIOL CHEM, V269, P19494
   Pettit DAD, 1998, J NEUROSCI RES, V51, P391
   Pi-Sunyer F, 2006, JAMA-J AM MED ASSOC, V295, P761, DOI 10.1001/jama.295.7.761
   Piomelli D, 2000, TRENDS PHARMACOL SCI, V21, P218, DOI 10.1016/S0165-6147(00)01482-6
   Piomelli D, 2003, NAT REV NEUROSCI, V4, P873, DOI 10.1038/nrn1247
   Porter AC, 2002, J PHARMACOL EXP THER, V301, P1020, DOI 10.1124/jpet.301.3.1020
   Roberts JC, 2004, BRAIN RES, V995, P176, DOI 10.1016/j.brainres.2003.10.001
   Robson P, 2001, BRIT J PSYCHIAT, V178, P107, DOI 10.1192/bjp.178.2.107
   Ross RA, 2003, BRIT J PHARMACOL, V140, P790, DOI 10.1038/sj.bjp.0705467
   Rowland NE, 2001, PSYCHOPHARMACOLOGY, V159, P111, DOI 10.1007/s002130100910
   Salzet M, 2000, EUR J BIOCHEM, V267, P4917, DOI 10.1046/j.1432-1327.2000.01550.x
   Sasaki T, 1997, LIFE SCI, V61, P1803, DOI 10.1016/S0024-3205(97)00804-7
   Schwartz MW, 2000, NATURE, V404, P661, DOI 10.1038/35007534
   SHARKEY KA, 2005, SCI STKE, V277, P15
   Song ZH, 1996, MOL PHARMACOL, V49, P891
   Stella N, 2001, EUR J PHARMACOL, V425, P189, DOI 10.1016/S0014-2999(01)01182-7
   Stella N, 1997, NATURE, V388, P773, DOI 10.1038/42015
   Stella N, 2004, GLIA, V48, P267, DOI 10.1002/glia.20084
   SUGIURA T, 1995, BIOCHEM BIOPH RES CO, V215, P89, DOI 10.1006/bbrc.1995.2437
   Sugiura T, 1996, BIOCHEM BIOPH RES CO, V218, P113, DOI 10.1006/bbrc.1996.0020
   Sugiura T, 1997, J BIOCHEM-TOKYO, V122, P890
   Tsou K, 1998, NEUROSCIENCE, V83, P393, DOI 10.1016/S0306-4522(97)00436-3
   Valverde O, 2005, HANDB EXP PHARMACOL, V168, P117
   van der Stelt M, 2005, EMBO J, V24, P3026, DOI 10.1038/sj.emboj.7600784
   Van Gaal LF, 2005, LANCET, V365, P1389, DOI 10.1016/S0140-6736(05)66374-X
   Waksman Y, 1999, J PHARMACOL EXP THER, V288, P1357
   Waleh NS, 2002, GENE, V291, P203, DOI 10.1016/S0378-1119(02)00598-X
   WHEELER DB, 1994, SCIENCE, V264, P107, DOI 10.1126/science.7832825
   Williams CM, 2002, PHARMACOL BIOCHEM BE, V71, P333, DOI 10.1016/S0091-3057(01)00694-3
   Woods SC, 2004, AM J PHYSIOL-GASTR L, V286, pG7, DOI 10.1152/ajpgi.00448.2003
NR 128
TC 32
Z9 39
U1 0
U2 2
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
BN 978-1-57331-625-5
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2006
VL 1083
BP 270
EP 305
DI 10.1196/annals.1367.024
PG 36
WC Endocrinology & Metabolism; Multidisciplinary Sciences
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Science & Technology - Other Topics
GA BFR90
UT WOS:000244102900018
PM 17148745
DA 2025-06-11
ER

PT J
AU Gong, K
   Zhang, Z
   Chen, SS
   Zhu, XR
   Wang, MY
   Yang, XY
   Ding, C
   Han, JH
   Li, QS
   Duan, YJ
AF Gong, Ke
   Zhang, Zhen
   Chen, Sha-sha
   Zhu, Xin-ran
   Wang, Meng-yao
   Yang, Xin-yue
   Ding, Chen
   Han, Ji-hong
   Li, Qing-shan
   Duan, Ya-jun
TI 6-Methyl flavone inhibits Nogo-B expression and improves high fructose
   diet-induced liver injury in mice
SO ACTA PHARMACOLOGICA SINICA
LA English
DT Article
DE metabolic syndrome; glycolipid metabolism; liver injury; high fructose;
   6-methyl flavone; Nogo-B
ID METABOLIC-DISORDERS; DISEASE; CHREBP; CELL; AUTOPHAGY; LIPOTOXICITY;
   ACTIVATION; BEVERAGES; OBESITY; CANCER
AB Excessive fructose consumption increases hepatic de novo lipogenesis, resulting in cellular stress, inflammation and liver injury. Nogo-B is a resident protein of the endoplasmic reticulum that regulates its structure and function. Hepatic Nogo-B is a key protein in glycolipid metabolism, and inhibition of Nogo-B has protective effects against metabolic syndrome, thus small molecules that inhibit Nogo-B have therapeutic benefits for glycolipid metabolism disorders. In this study we tested 14 flavones/isoflavones in hepatocytes using dual luciferase reporter system based on the Nogo-B transcriptional response system, and found that 6-methyl flavone (6-MF) exerted the strongest inhibition on Nogo-B expression in hepatocytes with an IC50 value of 15.85 mu M. Administration of 6-MF (50 mg.kg(-1).d(-1), i.g. for 3 weeks) significantly improved insulin resistance along with ameliorated liver injury and hypertriglyceridemia in high fructose diet-fed mice. In HepG2 cells cultured in a media containing an FA-fructose mixture, 6-MF (15 mu M) significantly inhibited lipid synthesis, oxidative stress and inflammatory responses. Furthermore, we revealed that 6-MF inhibited Nogo-B/ChREBP-mediated fatty acid synthesis and reduced lipid accumulation in hepatocytes by restoring cellular autophagy and promoting fatty acid oxidation via the AMPKa-mTOR pathway. Thus, 6-MF may serve as a potential Nogo-B inhibitor to treat metabolic syndrome caused by glycolipid metabolism dysregulation.
C1 [Gong, Ke; Zhang, Zhen; Chen, Sha-sha; Zhu, Xin-ran; Wang, Meng-yao; Han, Ji-hong; Li, Qing-shan] Hefei Univ Technol, Key Lab Metab & Regulat Major Dis, Anhui Higher Educ Inst, Hefei 230031, Peoples R China.
   [Yang, Xin-yue; Ding, Chen; Duan, Ya-jun] Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Cardiol, Div Life Sci & Med, Hefei 230001, Peoples R China.
   [Han, Ji-hong] Nankai Univ, Coll Life Sci, State Key Lab Med Chem Biol, Key Lab Bioact Mat,Minist Educ, Tianjin 300071, Peoples R China.
C3 Hefei University of Technology; Chinese Academy of Sciences; University
   of Science & Technology of China, CAS; Ministry of Education - China;
   Nankai University
RP Li, QS (corresponding author), Hefei Univ Technol, Key Lab Metab & Regulat Major Dis, Anhui Higher Educ Inst, Hefei 230031, Peoples R China.; Duan, YJ (corresponding author), Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Cardiol, Div Life Sci & Med, Hefei 230001, Peoples R China.
EM liqs@hfut.edu.cn; yajunduan@ustc.edu.cn
RI LI, QS/IED-7767-2023; Duan, Yajun/LJK-9029-2024; Gong, Ke/H-9596-2017;
   Sakura, yoyo/IYJ-3608-2023; ding, chen/KDN-1285-2024
FU China NSFC [U22A20272, 82173807, 81973316]; Tianjin Municipal Science
   and Technology Commission of China [20JCZDJC00710]; Fundamental Research
   Funds for the Central Universities (Nankai University) [63211045]
FX Support was provided by China NSFC grants U22A20272 and~82173807 to YJD,
   81973316 to JHH; Tianjin Municipal Science and Technology Commission of
   China Grant 20JCZDJC00710 and the Fundamental Research Funds for the
   Central Universities (Nankai University) 63211045 to JHH.
CR Amorim R, 2022, REDOX BIOL, V55, DOI 10.1016/j.redox.2022.102400
   Balamurugan K, 2022, ISCIENCE, V25, DOI 10.1016/j.isci.2022.103766
   Benhamed F, 2012, J CLIN INVEST, V122, P2176, DOI 10.1172/JCI41636
   Bray GA, 2004, AM J CLIN NUTR, V79, P537
   Byrnes K, 2022, ACTA PHARM SIN B, V12, P33, DOI 10.1016/j.apsb.2021.07.021
   Cao Y, 2021, PHARMACOL RES, V174, DOI 10.1016/j.phrs.2021.105919
   Chalasani NP, 2017, HEPATOLOGY, V66, p303A
   Chen Q, 2017, NUTRIENTS, V9, DOI 10.3390/nu9020096
   Chen YL, 2015, ARTERIOSCL THROM VAS, V35, P948, DOI 10.1161/ATVBAHA.114.305116
   Clarkson AN, 2019, J CEREBR BLOOD F MET, V39, P1266, DOI 10.1177/0271678X18755628
   Cursio R, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/480508
   Di Lorenzo A, 2011, BLOOD, V117, P2284, DOI 10.1182/blood-2010-04-281956
   Diggle CP, 2009, J HISTOCHEM CYTOCHEM, V57, P763, DOI 10.1369/jhc.2009.953190
   Duan YJ, 2012, J BIOL CHEM, V287, P23667, DOI 10.1074/jbc.M112.350181
   Egan DF, 2011, AUTOPHAGY, V7, P645, DOI 10.4161/auto.7.6.15123
   Federico A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13041314
   Gambino R, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17040479
   Gao LL, 2013, HEPATOLOGY, V57, P1992, DOI 10.1002/hep.26235
   Gao Y, 2021, PHARMACOL RES, V167, DOI 10.1016/j.phrs.2021.105561
   González-Rodríguez A, 2014, CELL DEATH DIS, V5, DOI 10.1038/cddis.2014.162
   Gutiérrez-Venegas G, 2010, INT IMMUNOPHARMACOL, V10, P1003, DOI 10.1016/j.intimp.2010.05.012
   Han YM, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-08585-4
   Hannou SA, 2018, J CLIN INVEST, V128, P545, DOI 10.1172/JCI96702
   Herzig S, 2018, NAT REV MOL CELL BIO, V19, P121, DOI 10.1038/nrm.2017.95
   Hostetler GL, 2017, ADV NUTR, V8, P423, DOI 10.3945/an.116.012948
   Jegatheesan P, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030230
   Jegatheesan P, 2015, J NUTR, V145, P2273, DOI 10.3945/jn.115.218982
   Jia JY, 2019, AUTOPHAGY, V15, P169, DOI 10.1080/15548627.2018.1505155
   Johnson RJ, 2017, ADV NUTR, V8, P412, DOI 10.3945/an.116.014654
   Kim MS, 2016, J CLIN INVEST, V126, P4372, DOI 10.1172/JCI81993
   Kim YC, 2015, J CLIN INVEST, V125, P25, DOI 10.1172/JCI73939
   Levine B, 2019, CELL, V176, P11, DOI 10.1016/j.cell.2018.09.048
   Liu Y, 2018, J LIPID RES, V59, P439, DOI 10.1194/jlr.M080440
   Maher P, 2007, BRAIN RES, V1173, P117, DOI 10.1016/j.brainres.2007.07.061
   Malik VS, 2010, CIRCULATION, V121, P1356, DOI 10.1161/CIRCULATIONAHA.109.876185
   Mota M, 2016, METABOLISM, V65, P1049, DOI 10.1016/j.metabol.2016.02.014
   Oertle T, 2003, J MOL BIOL, V325, P299, DOI 10.1016/S0022-2836(02)01179-8
   Park JK, 2017, HEPATOLOGY, V65, P1720, DOI 10.1002/hep.29051
   Rada P, 2020, CELL DEATH DIS, V11, DOI 10.1038/s41419-020-03003-w
   Sasi USS, 2020, TOXICOL IN VITRO, V68, DOI 10.1016/j.tiv.2020.104952
   Shukla S, 2006, MOL CANCER THER, V5, P843, DOI 10.1158/1535-7163.MCT-05-0370
   Sun DD, 2020, SIGNAL TRANSDUCT TAR, V5, DOI 10.1038/s41392-020-00281-w
   Tian Y, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-11274-x
   Wang XL, 2022, J BIOL CHEM, V298, DOI 10.1016/j.jbc.2022.101561
   Wen HY, 2022, INT J BIOL SCI, V18, P2898, DOI 10.7150/ijbs.70975
   Xu K, 2017, CELL RES, V27, P1100, DOI 10.1038/cr.2017.100
   Yu M, 2020, CELL SIGNAL, V65, DOI 10.1016/j.cellsig.2019.109429
   Zámbó V, 2013, WORLD J HEPATOL, V5, P550, DOI 10.4254/wjh.v5.i10.550
   Zhang DH, 2011, HEPATOLOGY, V53, P1306, DOI 10.1002/hep.24200
   Zhang DQ, 2017, J CLIN INVEST, V127, P2855, DOI 10.1172/JCI89934
   Zhang S, 2020, J HEPATOL, V73, P1482, DOI 10.1016/j.jhep.2020.07.034
   Zhang S, 2020, BRIT J PHARMACOL, V177, P1041, DOI 10.1111/bph.14886
   Zhang Y, 2020, MOL MED REP, V22, P2174, DOI 10.3892/mmr.2020.11309
   Zhao L, 2016, MOL NUTR FOOD RES, V60, P909, DOI 10.1002/mnfr.201500635
   Zhou J, 2022, THYROID, V32, P725, DOI 10.1089/thy.2021.0621
NR 55
TC 6
Z9 6
U1 2
U2 23
PU NATURE PUBL GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1671-4083
EI 1745-7254
J9 ACTA PHARMACOL SIN
JI Acta Pharmacol. Sin.
PD NOV
PY 2023
VL 44
IS 11
BP 2216
EP 2229
AR s41401-023-01121-7
DI 10.1038/s41401-023-01121-7
EA JUL 2023
PG 14
WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA GW6A4
UT WOS:001025045100003
PM 37402997
OA Green Published
DA 2025-06-11
ER

PT J
AU Asrih, M
   Jornayvaz, FR
AF Asrih, Mohamed
   Jornayvaz, Francois R.
TI Metabolic syndrome and nonalcoholic fatty liver disease: Is insulin
   resistance the link?
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Review
DE Metabolic syndrome; NAFLD; Insulin resistance; Ectopic lipids;
   Inflammation
ID GROWTH-FACTOR 21; ENDOPLASMIC-RETICULUM STRESS; INDUCED HEPATIC
   STEATOSIS; ACTIVATED RECEPTOR-ALPHA; NECROSIS-FACTOR-ALPHA; TOLL-LIKE
   RECEPTORS; KINASE-C-EPSILON; ENERGY-EXPENDITURE; ADIPOSE-TISSUE;
   VISCERAL FAT
AB Metabolic syndrome (MetS) is a disease composed of different risk factors such as obesity, type 2 diabetes or dyslipidemia. The prevalence of this syndrome is increasing worldwide in parallel with the rise in obesity. Nonalcoholic fatty liver disease (NAFLD) is now the most frequent chronic liver disease in western countries, affecting more than 30% of the general population. NAFLD encompasses a spectrum of liver manifestations ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis and cirrhosis, which may ultimately progress to hepatocellular carcinoma. There is accumulating evidence supporting an association between NAFLD and MetS. Indeed, NAFLD is recognized as the liver manifestation of MetS. Insulin resistance is increasingly recognized as a key factor linking MetS and NAFLD. Insulin resistance is associated with excessive fat accumulation in ectopic tissues, such as the liver, and increased circulating free fatty acids, which can further promote inflammation and endoplasmic reticulum stress. This in turn aggravates and maintains the insulin resistant state, constituting a vicious cycle. Importantly, evidence shows that most of the patients developing NAFLD present at least one of the MetS traits. This review will define MetS and NAFLD, provide an overview of the common pathophysiological mechanisms linking MetS and NAFLD, and give a perspective regarding treatment of these ever growing metabolic diseases. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Asrih, Mohamed; Jornayvaz, Francois R.] CHU Vaudois, Serv Endocrinol Diabet & Metab, CH-1011 Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV)
RP Jornayvaz, FR (corresponding author), CHU Vaudois, Serv Endocrinol Diabet & Metab, Rue Bugnon 46, CH-1011 Lausanne, Switzerland.
EM Francois.Jornayvaz@chuv.ch
RI Jornayvaz, François/AAL-2134-2020
OI Jornayvaz, Francois/0000-0001-9425-3137
FU Helmut Horten Foundation; SwissLife
FX This work was supported by the Helmut Horten Foundation and SwissLife.
CR Aguirre V, 2000, J BIOL CHEM, V275, P9047, DOI 10.1074/jbc.275.12.9047
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Angulo P, 2002, NEW ENGL J MED, V346, P1221, DOI 10.1038/nrdp.2015.80
   Arumugam M, 2011, NATURE, V473, P174, DOI 10.1038/nature09944
   Asrih M, 2014, CLIN NUTR, V33, P186, DOI 10.1016/j.clnu.2013.11.003
   Asrih M, 2013, J ENDOCRINOL, V218, pR25, DOI 10.1530/JOE-13-0201
   Athyros VG, 2006, CURR MED RES OPIN, V22, P873, DOI 10.1185/030079906X104696
   Auboeuf D, 1997, DIABETES, V46, P1319, DOI 10.2337/diabetes.46.8.1319
   Badran M, 2011, J OBES, V2011, DOI 10.1155/2011/686430
   Birkenfeld AL, 2011, J BIOL CHEM, V286, P36163, DOI 10.1074/jbc.M111.228817
   Birkenfeld AL, 2011, CELL METAB, V14, P184, DOI 10.1016/j.cmet.2011.06.009
   Bruning JC, 1998, MOL CELL, V2, P559, DOI 10.1016/S1097-2765(00)80155-0
   Bugianesi E, 2005, HEPATOLOGY, V42, P987, DOI 10.1002/hep.20920
   Campanati A, 2013, J GASTROENTEROL, V48, P839, DOI 10.1007/s00535-012-0678-9
   Camporez JPG, 2013, ENDOCRINOLOGY, V154, P3099, DOI 10.1210/en.2013-1191
   Camporez JPG, 2013, ENDOCRINOLOGY, V154, P1021, DOI 10.1210/en.2012-1989
   Cantley JL, 2013, P NATL ACAD SCI USA, V110, P1869, DOI 10.1073/pnas.1219456110
   Cao H, 2006, DIABETES, V55, P1915, DOI 10.2337/db05-1496
   Cariou B, 2013, DIABETES CARE, V36, P2923, DOI 10.2337/dc12-2012
   Carter R, 2012, CLIN MED, V12, P456, DOI 10.7861/clinmedicine.12-5-456
   Chavez AO, 2009, DIABETES CARE, V32, P1542, DOI 10.2337/dc09-0684
   Choi SS, 2008, CURR OPIN LIPIDOL, V19, P295, DOI 10.1097/MOL.0b013e3282ff5e55
   Chugh PK, 2012, J CLIN PHARM THER, V37, P525, DOI 10.1111/j.1365-2710.2012.01347.x
   Contos Melissa J, 2004, Clin Liver Dis, V8, P481, DOI 10.1016/j.cld.2004.04.013
   Cotillard A, 2013, NATURE, V500, P585, DOI 10.1038/nature12480
   CUMMINGS JH, 1981, GUT, V22, P763, DOI 10.1136/gut.22.9.763
   Czaja MJ, 2010, TRENDS ENDOCRIN MET, V21, P707, DOI 10.1016/j.tem.2010.08.010
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   de Luca C, 2008, FEBS LETT, V582, P97, DOI 10.1016/j.febslet.2007.11.057
   Dominguez H, 2005, J VASC RES, V42, P517, DOI 10.1159/000088261
   Donath MY, 2011, NAT REV IMMUNOL, V11, P98, DOI 10.1038/nri2925
   Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI23621
   Dushay J, 2010, GASTROENTEROLOGY, V139, P456, DOI 10.1053/j.gastro.2010.04.054
   Eguchi Y, 2006, J GASTROENTEROL, V41, P462, DOI 10.1007/s00535-006-1790-5
   Eslami L, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008623.pub2
   Farazi PA, 2006, NAT REV CANCER, V6, P674, DOI 10.1038/nrc1934
   Fessler MB, 2009, CURR OPIN LIPIDOL, V20, P379, DOI 10.1097/MOL.0b013e32832fa5c4
   Fisher FM, 2010, DIABETES, V59, P2781, DOI 10.2337/db10-0193
   Foltz IN, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3004690
   Foster T, 2011, AM J GASTROENTEROL, V106, P71, DOI 10.1038/ajg.2010.299
   Fresno Manuel, 2011, Archives of Physiology and Biochemistry, V117, P151, DOI 10.3109/13813455.2011.562514
   Fruchart JC, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-82
   Fullerton MD, 2013, NAT MED, V19, P1649, DOI 10.1038/nm.3372
   Gadd VL, 2013, LIVER INT, V33, P569, DOI 10.1111/liv.12050
   Gaich G, 2013, CELL METAB, V18, P333, DOI 10.1016/j.cmet.2013.08.005
   Gao ZG, 2009, DIABETES, V58, P1509, DOI 10.2337/db08-1637
   Gariani K, 2013, DIABETES METAB, V39, P16, DOI 10.1016/j.diabet.2012.11.002
   Goldfine AB, 2008, CTS-CLIN TRANSL SCI, V1, P36, DOI 10.1111/j.1752-8062.2008.00026.x
   Gregor MF, 2013, CELL REP, V3, P1430, DOI 10.1016/j.celrep.2013.03.042
   Haffner SM, 2003, AM J CARDIOL, V92, p18J, DOI 10.1016/S0002-9149(03)00612-X
   Harrison SA, 2004, ALIMENT PHARM THERAP, V20, P623, DOI 10.1111/j.1365-2036.2004.02153.x
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   HODGE AM, 1995, OBES RES, V3, pS77, DOI 10.1002/j.1550-8528.1995.tb00450.x
   Hoque ME, 2014, NUTR REV, V72, P541, DOI 10.1111/nure.12130
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Hotta K, 2000, ARTERIOSCL THROM VAS, V20, P1595, DOI 10.1161/01.ATV.20.6.1595
   Huang J, 2013, J PHARMACOL EXP THER, V346, P270, DOI 10.1124/jpet.113.204420
   Hyogo H, 2008, METABOLISM, V57, P1711, DOI 10.1016/j.metabol.2008.07.030
   Jeong SK, 2008, J KOREAN MED SCI, V23, P789, DOI 10.3346/jkms.2008.23.5.789
   Jiang S, 2014, J BIOL CHEM, V289, P29751, DOI 10.1074/jbc.M114.565960
   Jornayvaz FR, 2012, CELL METAB, V15, P574, DOI 10.1016/j.cmet.2012.03.005
   Jornayvaz FR, 2012, ENDOCRINOLOGY, V153, P583, DOI 10.1210/en.2011-1793
   Jornayvaz FR, 2011, P NATL ACAD SCI USA, V108, P5748, DOI 10.1073/pnas.1103451108
   Jornayvaz FR, 2010, AM J PHYSIOL-ENDOC M, V299, pE808, DOI 10.1152/ajpendo.00361.2010
   Jornayvaz FR, 2010, ANNU REV NUTR, V30, P273, DOI 10.1146/annurev.nutr.012809.104726
   Jung TW, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0066529
   Jurczak MJ, 2012, J BIOL CHEM, V287, P2558, DOI 10.1074/jbc.M111.316760
   Kagansky N, 2004, LIVER INT, V24, P588, DOI 10.1111/j.1478-3231.2004.0969.x
   Kamada Y, 2008, J GASTROENTEROL, V43, P811, DOI 10.1007/s00535-008-2213-6
   Kantartzis K, 2009, DIABETES, V58, P2616, DOI 10.2337/db09-0279
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kim HJ, 2004, ARCH INTERN MED, V164, P2169, DOI 10.1001/archinte.164.19.2169
   Kim JK, 2000, J CLIN INVEST, V105, P1791, DOI 10.1172/JCI8305
   Kim JK, 2000, J BIOL CHEM, V275, P8456, DOI 10.1074/jbc.275.12.8456
   Kim JK, 2001, P NATL ACAD SCI USA, V98, P7522, DOI 10.1073/pnas.121164498
   Könner AC, 2011, TRENDS ENDOCRIN MET, V22, P16, DOI 10.1016/j.tem.2010.08.007
   Kootte RS, 2012, DIABETES OBES METAB, V14, P112, DOI 10.1111/j.1463-1326.2011.01483.x
   Kopelman PG, 2000, NATURE, V404, P635, DOI 10.1038/35007508
   Kotani K, 2004, J CLIN INVEST, V114, P1666, DOI 10.1172/JCI200421341
   Kumashiro N, 2013, HEPATOLOGY, V57, P1763, DOI 10.1002/hep.26170
   Kumashiro N, 2011, P NATL ACAD SCI USA, V108, P16381, DOI 10.1073/pnas.1113359108
   Kwon YM, 2012, AM J GASTROENTEROL, V107, P1852, DOI 10.1038/ajg.2012.314
   Lanthier N, 2010, AM J PHYSIOL-GASTR L, V298, pG107, DOI 10.1152/ajpgi.00391.2009
   Lee HY, 2011, HEPATOLOGY, V54, P1650, DOI 10.1002/hep.24571
   Lee YK, 2010, SCIENCE, V330, P1768, DOI 10.1126/science.1195568
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Li HT, 2010, J HEPATOL, V53, P934, DOI 10.1016/j.jhep.2010.05.018
   Loomba R, 2009, ALIMENT PHARM THER, V29, P172, DOI 10.1111/j.1365-2036.2008.03869.x
   Lumeng CN, 2008, DIABETES, V57, P3239, DOI 10.2337/db08-0872
   Marchesini G, 2003, HEPATOLOGY, V37, P917, DOI 10.1053/jhep.2003.50161
   McKenney RL, 2011, SURG CLIN N AM, V91, P1139, DOI 10.1016/j.suc.2011.08.007
   Michael MD, 2000, MOL CELL, V6, P87, DOI 10.1016/S1097-2765(00)00010-1
   Mittendorfer B, 2009, OBESITY, V17, P1872, DOI 10.1038/oby.2009.224
   Miura K, 2010, GASTROENT RES PRACT, V2010, DOI 10.1155/2010/362847
   Musaiger AO, 1996, J TROP PEDIATRICS, V42, P121, DOI 10.1093/tropej/42.2.121
   Musso G, 2008, DIABETES CARE, V31, P562, DOI 10.2337/dc07-1526
   Musso G, 2011, ANN MED, V43, P617, DOI 10.3109/07853890.2010.518623
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Ogden Cynthia L, 2010, NCHS Data Brief, P1
   Onat A, 2011, EXPERT OPIN PHARMACO, V12, P1887, DOI 10.1517/14656566.2011.585462
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Ozes ON, 2001, P NATL ACAD SCI USA, V98, P4640, DOI 10.1073/pnas.051042298
   Palermo A, 2014, DIABETES-METAB RES, V30, P4, DOI 10.1002/dmrr.2513
   Pardina E, 2009, OBES SURG, V19, P894, DOI 10.1007/s11695-008-9739-9
   Park HS, 2004, J KOREAN MED SCI, V19, P202, DOI 10.3346/jkms.2004.19.2.202
   Pawlak M, 2014, HEPATOLOGY, V60, P1593, DOI 10.1002/hep.27297
   Perry RJ, 2014, NATURE, V510, P84, DOI 10.1038/nature13478
   Petersen KF, 2003, SCIENCE, V300, P1140, DOI 10.1126/science.1082889
   Petersen KF, 2002, J CLIN INVEST, V109, P1345, DOI 10.1172/JCI0215001
   Petersen KF, 2007, P NATL ACAD SCI USA, V104, P12587, DOI 10.1073/pnas.0705408104
   Petersen KF, 2006, P NATL ACAD SCI USA, V103, P18273, DOI 10.1073/pnas.0608537103
   Petersen KF, 2010, NEW ENGL J MED, V362, P1082, DOI 10.1056/NEJMoa0907295
   Petta S, 2010, HEPATOLOGY, V52, P1543, DOI 10.1002/hep.23859
   POPKIN BM, 1994, NUTR REV, V52, P285, DOI 10.1111/j.1753-4887.1994.tb01460.x
   Promrat K, 2004, HEPATOLOGY, V39, P188, DOI 10.1002/hep.20012
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Raso GM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0068626
   Reaven G, 2002, CIRCULATION, V106, P286, DOI 10.1161/01.CIR.0000019884.36724.D9
   Reynolds K, 2009, CURR HYPERTENS REP, V11, P150, DOI 10.1007/s11906-009-0026-5
   Romeo S, 2008, NAT GENET, V40, P1461, DOI 10.1038/ng.257
   Sabapathy K, 2004, MOL CELL, V15, P713, DOI 10.1016/j.molcel.2004.08.028
   Samuel VT, 2007, J CLIN INVEST, V117, P739, DOI 10.1172/JCI30400
   Samuel VT, 2004, J BIOL CHEM, V279, P32345, DOI 10.1074/jbc.M313478200
   Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929
   Savage DB, 2005, J CLIN ENDOCR METAB, V90, P1446, DOI 10.1210/jc.2004-1494
   Schattenberg JM, 2006, HEPATOLOGY, V43, P163, DOI 10.1002/hep.20999
   Schwiertz A, 2010, OBESITY, V18, P190, DOI 10.1038/oby.2009.167
   Shi H, 2006, J CLIN INVEST, V116, P3015, DOI 10.1172/JCI28898
   Shimomura I, 1999, NATURE, V401, P73, DOI 10.1038/43448
   Shiri-Sverdlov R, 2006, J HEPATOL, V44, P732, DOI 10.1016/j.jhep.2005.10.033
   Simons LA, 2011, HEART LUNG CIRC, V20, P214, DOI 10.1016/j.hlc.2010.12.005
   Singh R, 2009, HEPATOLOGY, V49, P87, DOI 10.1002/hep.22578
   Sinn DH, 2012, AM J GASTROENTEROL, V107, P561, DOI 10.1038/ajg.2011.400
   Smits LP, 2013, GASTROENTEROLOGY, V145, P946, DOI 10.1053/j.gastro.2013.08.058
   So JS, 2012, CELL METAB, V16, P487, DOI 10.1016/j.cmet.2012.09.004
   Solinas G, 2010, FASEB J, V24, P2596, DOI 10.1096/fj.09-151340
   Spranger J, 2003, DIABETES, V52, P812, DOI 10.2337/diabetes.52.3.812
   Taniguchi CM, 2006, NAT REV MOL CELL BIO, V7, P85, DOI 10.1038/nrm1837
   Tarantino G, 2012, J TRANSL MED, V10, DOI 10.1186/1479-5876-10-50
   Targher G, 2008, OBESITY, V16, P1394, DOI 10.1038/oby.2008.64
   Tilg H, 2010, HEPATOLOGY, V52, P1836, DOI 10.1002/hep.24001
   Tran TT, 2008, CELL METAB, V7, P410, DOI 10.1016/j.cmet.2008.04.004
   Tuncman G, 2006, P NATL ACAD SCI USA, V103, P10741, DOI 10.1073/pnas.0603509103
   Vanni E, 2010, DIGEST LIVER DIS, V42, P320, DOI 10.1016/j.dld.2010.01.016
   Véniant MM, 2012, ENDOCRINOLOGY, V153, P4192, DOI 10.1210/en.2012-1211
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Webber L, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2014-004787
   Weiss R, 2005, J CLIN ENDOCR METAB, V90, P3731, DOI 10.1210/jc.2004-2305
   Wu AL, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3002669
   Wu GD, 2011, SCIENCE, V334, P105, DOI 10.1126/science.1208344
   Xu CY, 2005, J CLIN INVEST, V115, P2656, DOI 10.1172/JCI26373
   Xu J, 2009, DIABETES, V58, P250, DOI 10.2337/db08-0392
   Zhang X, 2008, DIABETES, V57, P1246, DOI 10.2337/db07-1476
NR 154
TC 234
Z9 262
U1 1
U2 50
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD DEC 15
PY 2015
VL 418
SI SI
BP 55
EP 65
DI 10.1016/j.mce.2015.02.018
PN 1
PG 11
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA DB3AH
UT WOS:000368381400008
PM 25724480
OA Green Published
DA 2025-06-11
ER

PT J
AU Sangaleti, CT
   Katayama, KY
   De Angelis, K
   de Moraes, TL
   Araújo, AA
   Lopes, HF
   Camacho, C
   Bortolotto, LA
   Michelini, LC
   Irigoyen, MC
   Olofsson, PS
   Barnaby, DP
   Tracey, KJ
   Pavlov, VA
   Colombo, FMC
AF Sangaleti, Carine Teles
   Katayama, Keyla Yukari
   De Angelis, Katia
   Lemos de Moraes, Tercio
   Araujo, Amanda Aparecida
   Lopes, Heno F.
   Camacho, Cleber
   Bortolotto, Luiz Aparecido
   Michelini, Lisete Compagno
   Irigoyen, Maria Claudia
   Olofsson, Peder S.
   Barnaby, Douglas P.
   Tracey, Kevin J.
   Pavlov, Valentin A.
   Consolim Colombo, Fernanda Marciano
TI The Cholinergic Drug Galantamine Alleviates Oxidative Stress Alongside
   Anti-inflammatory and Cardio-Metabolic Effects in Subjects With the
   Metabolic Syndrome in a Randomized Trial
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Article
DE metabolic syndrome; galantamine; cholinergic; oxidative stress; heart
   rate variability; autonomic modulation; inflammation
ID INFLAMMATION; OBESITY; HYPERTENSION; DYSFUNCTION; MECHANISMS; PATHWAYS;
   DISEASE; SYSTEM
AB Background: The metabolic syndrome (MetS) is an obesity-associated disorder of pandemic proportions and limited treatment options. Oxidative stress, low-grade inflammation and altered neural autonomic regulation, are important components and drivers of pathogenesis. Galantamine, an acetylcholinesterase inhibitor and a cholinergic drug that is clinically-approved (for Alzheimer's disease) has been implicated in neural cholinergic regulation of inflammation in several conditions characterized with immune and metabolic derangements. Here we examined the effects of galantamine on oxidative stress in parallel with inflammatory and cardio-metabolic parameters in subjects with MetS.
   Trial Design and Methods: The effects of galantamine treatment, 8 mg daily for 4 weeks or placebo, followed by 16 mg daily for 8 weeks or placebo were studied in randomly assigned subjects with MetS (n = 22 per group) of both genders. Oxidative stress, including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase activities, lipid and protein peroxidation, and nitrite levels were analyzed before and at the end of the treatment. In addition, plasma cytokine and adipokine levels, insulin resistance (HOMA-IR) and other relevant cardio-metabolic indices were analyzed. Autonomic regulation was also examined by heart rate variability (HRV) before treatment, and at every 4 weeks of treatment.
   Results: Galantamine treatment significantly increased antioxidant enzyme activities, including SOD [+1.65 USOD/mg protein, [95% CI 0.39-2.92], P = 0.004] and CAT [+0.93 nmol/mg, [95% CI 0.34-1.51], P = 0.01], decreased lipid peroxidation [thiobarbituric acid reactive substances [log scale 0.72 pmol/mg, [95% CI 0.46-1.07], P = 0.05], and systemic nitrite levels [log scale 0.83 mu mol/mg protein, [95% CI 0.57-1.20], P = 0.04] compared with placebo. In addition, galantamine significantly alleviated the inflammatory state and insulin resistance, and decreased the low frequency/high frequency ratio of HRV, following 8 and 12 weeks of drug treatment.
   Conclusion: Low-dose galantamine alleviates oxidative stress, alongside beneficial anti-inflammatory, and metabolic effects, and modulates neural autonomic regulation in subjects with MetS. These findings are of considerable interest for further studies with the cholinergic drug galantamine to ameliorate MetS.
C1 [Sangaleti, Carine Teles; Bortolotto, Luiz Aparecido; Irigoyen, Maria Claudia; Consolim Colombo, Fernanda Marciano] Univ Sao Paulo, Hypertens Unit, Sao Paulo, Brazil.
   [Sangaleti, Carine Teles] Midwestern State Univ UNICENTRO, Postgrad Program Hlth Sci, Guarapuava, Parana, Brazil.
   [Katayama, Keyla Yukari; De Angelis, Katia; Lemos de Moraes, Tercio; Lopes, Heno F.; Camacho, Cleber; Consolim Colombo, Fernanda Marciano] Nove Julho Univ UNINOVE, Dept Nursing, Grad Program Nanosci & Biosci, Sao Paulo, Brazil.
   [De Angelis, Katia; Araujo, Amanda Aparecida] Fed Univ Sao Paulo UNIFESP, Dept Physiol, Sao Paulo, Brazil.
   [Michelini, Lisete Compagno] Univ Sao Paulo, Biomed Sci Inst, Dept Physiol & Biophys, Sao Paulo, Brazil.
   [Olofsson, Peder S.] Karolinska Inst, Dept Med, Ctr Bioelect Med, Immunobiol Lab, Stockholm, Sweden.
   [Olofsson, Peder S.; Barnaby, Douglas P.; Tracey, Kevin J.; Pavlov, Valentin A.] Northwell Hlth, Feinstein Inst Med Res, Manhasset, NY 11030 USA.
C3 Universidade de Sao Paulo; Universidade Estadual do Centro Oeste;
   Universidade Nove de Julho; Universidade Federal de Sao Paulo (UNIFESP);
   Universidade de Sao Paulo; Karolinska Institutet; Northwell Health
RP Colombo, FMC (corresponding author), Univ Sao Paulo, Hypertens Unit, Sao Paulo, Brazil.; Colombo, FMC (corresponding author), Nove Julho Univ UNINOVE, Dept Nursing, Grad Program Nanosci & Biosci, Sao Paulo, Brazil.; Pavlov, VA (corresponding author), Northwell Hlth, Feinstein Inst Med Res, Manhasset, NY 11030 USA.
EM vpavlov@northwell.edu; fernanda.consolim@uninove.br
RI DE ANGELIS, KATIA/I-6098-2016; Camacho, Cleber/I-8030-2019; Michelini,
   Lisete/C-6485-2012; Barnaby, Douglas/N-3872-2019; Lopes,
   Heno/H-9825-2013; Sangaleti, Carine/AAB-9168-2020; Bortolotto,
   Luiz/S-1940-2017; Irigoyen, maria Claudia/N-6880-2014; Camacho,
   Cleber/C-5220-2014
OI Barnaby, Douglas/0000-0002-2135-0224; Bortolotto,
   Luiz/0000-0002-4865-6442; Pavlov, Valentin/0000-0002-1994-2853;
   Irigoyen, maria Claudia/0000-0003-2097-3662; Michelini,
   Lisete/0000-0003-2978-5406; Camacho, Cleber/0000-0002-8653-0031
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP); Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq); National
   Institutes of Health (NIH) [NIH-NIGMS:R01GM128008, R35GM118182-01]
FX This study was supported by Fundacao de Amparo a Pesquisa do Estado de
   Sao Paulo (FAPESP), Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq), and by the National Institutes of Health (NIH)
   Grants NIH-NIGMS: R01GM128008 to VP, and R35GM118182-01 to KT. The
   funders of this study had no role in study design, data collection, data
   analysis, data interpretation, or manuscript writing. The corresponding
   author had full access to all the data of the study and had the final
   responsibility for the manuscript submission. This manuscript has been
   released as a pre-print at medRxiv (70).
CR [Anonymous], 1984, METHOD ENZYMOL
   Birks J, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005593
   Bonaz B, 2016, NEUROGASTROENT MOTIL, V28, P948, DOI 10.1111/nmo.12792
   Bonomini F, 2015, AGING DIS, V6, P109, DOI 10.14336/AD.2014.0305
   Buege J A, 1978, Methods Enzymol, V52, P302
   Camm AJ, 1996, CIRCULATION, V93, P1043
   Carrier A, 2017, ANTIOXID REDOX SIGN, V26, P429, DOI 10.1089/ars.2016.6929
   Chang EH, 2019, FRONT NEUROSCI-SWITZ, V13, DOI 10.3389/fnins.2019.00263
   Consolim-Colombo FM, 2017, JCI INSIGHT, V2, DOI 10.1172/jci.insight.93340
   Conti FF, 2014, BMC CARDIOVASC DISOR, V14, DOI 10.1186/1471-2261-14-185
   Díaz-Flores M, 2013, CAN J PHYSIOL PHARM, V91, P855, DOI 10.1139/cjpp-2012-0341
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Esser N, 2015, EXPERT OPIN INV DRUG, V24, P283, DOI 10.1517/13543784.2015.974804
   Fernández-Garcia JC, 2013, CURR VASC PHARMACOL, V11, P906, DOI 10.2174/15701611113116660175
   Gerritsen J, 2001, DIABETES CARE, V24, P1793, DOI 10.2337/diacare.24.10.1793
   Gowayed MA, 2015, EUR J PHARMACOL, V764, P547, DOI 10.1016/j.ejphar.2015.07.038
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Hanes WM, 2015, MOL MED, V21, P702, DOI 10.2119/molmed.2015.00142
   Isik AT, 2018, J AM GERIATR SOC, V66, P1805, DOI 10.1111/jgs.15415
   Isik AT, 2010, AM J GERIATR PHARMAC, V8, P454, DOI 10.1016/j.amjopharm.2010.09.001
   Ji H, 2014, MUCOSAL IMMUNOL, V7, P335, DOI 10.1038/mi.2013.52
   Kaushik V, 2018, AM J ALZHEIMERS DIS, V33, P73, DOI 10.1177/1533317517734352
   Koopman FA, 2016, P NATL ACAD SCI USA, V113, P8284, DOI 10.1073/pnas.1605635113
   Koskinen T, 2009, DIABETIC MED, V26, P354, DOI 10.1111/j.1464-5491.2009.02686.x
   Koziróg M, 2011, J PINEAL RES, V50, P261, DOI 10.1111/j.1600-079X.2010.00835.x
   Laborde S, 2018, HELIYON, V4, DOI 10.1016/j.heliyon.2018.e01002
   Lehner KR, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.00585
   Levine YA, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0104530
   Mancia G, 2007, J HYPERTENS, V25, P909, DOI 10.1097/HJH.0b013e328048d004
   MARKLUND SL, 1985, MUTAT RES, V148, P129, DOI 10.1016/0027-5107(85)90216-7
   Metz CN, 2021, J NEUROCHEM, V158, P1359, DOI 10.1111/jnc.15243
   Metz CN, 2018, AM J PHYSIOL-GASTR L, V315, pG651, DOI 10.1152/ajpgi.00195.2018
   Munyaka P, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0109272
   Netzer N, 2015, BIOMOLECULES, V5, P1143, DOI 10.3390/biom5021143
   Nordström P, 2013, EUR HEART J, V34, P2585, DOI 10.1093/eurheartj/eht182
   Ouchi N, 2011, NAT REV IMMUNOL, V11, P85, DOI 10.1038/nri2921
   Pavlov VA, 2006, P NATL ACAD SCI USA, V103, P5219, DOI 10.1073/pnas.0600506103
   Pavlov VA, 2021, PHARMACOL THERAPEUT, V222, DOI 10.1016/j.pharmthera.2020.107794
   Pavlov Valentin A, 2019, Bioelectron Med, V5, P5, DOI 10.1186/s42234-019-0021-3
   Pavlov VA, 2020, CSH PERSPECT MED, V10, DOI 10.1101/cshperspect.a034140
   Pavlov VA, 2018, ANNU REV IMMUNOL, V36, P783, DOI 10.1146/annurev-immunol-042617-053158
   Pavlov VA, 2017, NAT NEUROSCI, V20, P156, DOI 10.1038/nn.4477
   Pavlov VA, 2015, IMMUNOL RES, V63, P38, DOI 10.1007/s12026-015-8718-1
   Pavlov VA, 2009, BRAIN BEHAV IMMUN, V23, P41, DOI 10.1016/j.bbi.2008.06.011
   Pham GS, 2018, AM J PHYSIOL-REG I, V315, pR1261, DOI 10.1152/ajpregu.00362.2017
   de Melo LGP, 2017, PROG NEURO-PSYCHOPH, V78, P34, DOI 10.1016/j.pnpbp.2017.04.027
   Prvulovic D, 2010, EXPERT OPIN DRUG MET, V6, P345, DOI 10.1517/17425251003592137
   REZNICK AZ, 1994, METHOD ENZYMOL, V233, P357
   Risérus U, 2002, DIABETES CARE, V25, P1516, DOI 10.2337/diacare.25.9.1516
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Samaha FF, 2006, ARTERIOSCL THROM VAS, V26, P624, DOI 10.1161/01.ATV.0000200136.56716.30
   Sangaleti CT., 2020, GALANTAMINE ALLEVIAT, V2020, P2019, DOI [10.1101/2019.12.30.19016105, DOI 10.1101/2019.12.30.19016105]
   Satapathy SK, 2011, MOL MED, V17, P599, DOI 10.2119/molmed.2011.00083
   Schlaich M, 2015, LANCET DIABETES ENDO, V3, P148, DOI 10.1016/S2213-8587(14)70033-6
   Secnik J, 2020, BMJ OPEN DIAB RES CA, V8, DOI 10.1136/bmjdrc-2019-000833
   Soares Raquel, 2009, P85, DOI 10.1007/978-1-4020-9701-0_5
   Sureda A, 2016, MOL NUTR FOOD RES, V60, P2654, DOI 10.1002/mnfr.201600450
   Sutherland JP, 2004, METAB SYNDR RELAT D, V2, P82, DOI 10.1089/met.2004.2.82
   Tabrizi R, 2018, FOOD FUNCT, V9, P6117, DOI 10.1039/c8fo01259h
   Taché Y, 2016, J PHYSIOL-LONDON, V594, P5769, DOI 10.1113/JP271540
   Tentolouris N, 2006, ANN NY ACAD SCI, V1083, P129, DOI 10.1196/annals.1367.010
   Tilg H, 2006, NAT REV IMMUNOL, V6, P772, DOI 10.1038/nri1937
   Tracey KJ, 2002, NATURE, V420, P853, DOI 10.1038/nature01321
   Van Guilder GP, 2006, OBESITY, V14, P2127, DOI 10.1038/oby.2006.248
   Waldburger JM, 2008, ARTHRITIS RHEUM-US, V58, P2919, DOI 10.1002/art.23807
   Wang QZ, 2010, INT J VITAM NUTR RES, V80, P178, DOI 10.1024/0300-9831/a000015
   Whaley-Connell A, 2011, REV CARDIOVASC MED, V12, P21, DOI 10.3909/ricm0555
   Wu PH, 2015, SCI REP-UK, V5, DOI 10.1038/srep15451
   Xydakis AM, 2004, J CLIN ENDOCR METAB, V89, P2697, DOI 10.1210/jc.2003-031826
NR 69
TC 29
Z9 30
U1 1
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD MAR 11
PY 2021
VL 12
AR 613979
DI 10.3389/fimmu.2021.613979
PG 12
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA RB9PH
UT WOS:000632436400001
PM 33776997
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Forlico, S
   Baillie, A
   Keys, K
   Woollett, P
   Frydman, G
   Simpson, A
AF Forlico, Sophie
   Baillie, Andrew
   Keys, Kate
   Woollett, Peter
   Frydman, Georgia
   Simpson, Andrew
TI Gym and swim: a co-facilitated exercise program that improves community
   connection, confidence, and exercise habits in a community mental health
   service
SO DISCOVER MENTAL HEALTH
LA English
DT Article
DE Exercise; Physical activity; Severe mental illness; Schizophrenia;
   Psychosis; Physical health; Metabolic disease; Community-based;
   Co-facilitation; Exercise physiology; Peer support; Community
   connection; Social connection
ID MAJOR DEPRESSIVE DISORDER; METABOLIC SYNDROME; BIPOLAR DISORDER;
   SCHIZOPHRENIA; RELIABILITY; PREVALENCE; STATEMENT; ILLNESS; PEOPLE
AB High rates of cardiometabolic disease and poor physical health outcomes contribute to significant premature mortality in people living with severe mental illness (PLWSMI). Lifestyle interventions such as exercise are known to improve both physical and mental health outcomes, however the best way to deliver exercise programs for PLWSMI remains a challenge. This paper uses a pragmatic program evaluation of a co-delivered low-cost community-based exercise program implemented over a 6-month period. Of 46 referrals in the first half of 2023 to the SLHD Gym and Swim program, 13 gave consent to participate in standardised measures and qualitative interviews. Findings revealed an increase in average hours of sport/exercise, improvements in confidence to exercise independently and within group settings, as well as achievement of individualised goals. The success of the program was in part due to the co-facilitation between peer support workers and exercise physiologists, community connection and the established partnership between the public health service and the local government council. Results offer evidence to adopt and implement accessible and low-cost exercise opportunities in the community external to health services to address barriers of attendance for PLWSMI.
C1 [Forlico, Sophie; Keys, Kate; Woollett, Peter; Frydman, Georgia; Simpson, Andrew] Sydney Local Hlth Dist, Mental Hlth Serv, Sydney, Australia.
   [Baillie, Andrew] Sydney Local Hlth Dist, Sydney, Australia.
   [Baillie, Andrew] Univ Sydney, Sydney Sch Hlth Sci, Sydney, Australia.
C3 Sydney Local Health District; Sydney Local Health District; University
   of Sydney
RP Forlico, S (corresponding author), Sydney Local Hlth Dist, Mental Hlth Serv, Sydney, Australia.
EM sophieforlico@gmail.com
RI Baillie, Andrew/A-9154-2008; Simpson, Andrew/HKE-4814-2023
OI Keys, Kate/0009-0007-4194-754X; Baillie, Andrew/0000-0003-3424-5703;
   Woollett, Peter Hayes/0009-0001-5164-2869
FU Health Education Training Institute; Health Education Training Institute
   Mental Health Research Award; Sydney Local Health District; Inner West
   Council (IWC)
FX Sophie Forlico was funded by a Health Education Training Institute
   Mental Health Research Award to complete this research and it was
   supported by Sydney Local Health District. Special thanks go to Stella
   Galanis, Library Manager at Geoff Marel Library, Concord Hospital for
   completing a literature search and for providing ongoing access to
   relevant literature, as well as Hansi Eheliyagoda and Jordan McStraw who
   contributed to the literature review and collection of background
   information. We thank: Renata Tayler and Jemina Isbester who contributed
   to co-design focus group sessions and development of assessment tools;
   Paul La Cava and Raz Akyunare who contributed to co-design focus groups,
   development of assessment tools and data interpretation, as well as
   Linda Persson who contributed to co-design focus groups, development of
   assessment tools, conducting assessments and data interpretation. We
   acknowledge the partnership with the Inner West Council (IWC) for the
   agreement to use their facilities and equipment to deliver Gym and Swim.
   We would like to thank the participants of Gym and Swim who consented to
   take part in this study. An earlier version of this work was presented
   at the 33rd annual Mental Health Services Conference in Adelaide, South
   Australia, 15-18 August 2023. We recognise that preferred terminology in
   mental health care may vary. Throughout this paper, the term consumer is
   used to refer to an individual with lived or living experience of mental
   illness.
CR [Anonymous], 2016, Equally Well Consensus Statement: Improving the physical health and wellbeing of people living with mental illness in Australia
   Bijkerk LE, 2023, INT J BEHAV MED, V30, P155, DOI 10.1007/s12529-022-10086-6
   Braun V., 2006, QUAL RES PSYCHOL, V3, P77, DOI [DOI 10.1191/1478088706QP063OA, DOI 10.1080/14780887.2020.1769238]
   Brooks R, 2000, AUST NZ J PSYCHIAT, V34, P504, DOI 10.1080/j.1440-1614.2000.00755.x
   Byrne L., 2021, National lived experience (peer) workforce development guidelines
   Caple V, 2023, J PSYCHIATR MENT HLT, V30, P1170, DOI 10.1111/jpm.12945
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   Dray J, 2024, HEALTH EXPECT, V27, DOI 10.1111/hex.13934
   Fibbins H, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.791125
   Firth J, 2016, PSYCHOL MED, V46, P2869, DOI 10.1017/S0033291716001732
   Firth J, 2019, PSYCHOSOM MED, V81, P265, DOI 10.1097/PSY.0000000000000673
   Graham CR, 2017, J NERV MENT DIS, V205, P840, DOI 10.1097/NMD.0000000000000746
   Hancock N., 2019, Recovery assessment scale domains stages (RAS-DS) manual-Version 3
   Hancock N., 2014, Aust New Zealand J Psychiatr, V49, P1
   Harris PA, 2009, J BIOMED INFORM, V42, P377, DOI 10.1016/j.jbi.2008.08.010
   Healy Laura C, 2023, Int J Environ Res Public Health, V20, DOI 10.3390/ijerph20032291
   John AP, 2009, MED J AUSTRALIA, V190, P176, DOI 10.5694/j.1326-5377.2009.tb02342.x
   Kim MH, 2022, FRONT CARDIOVASC MED, V9, DOI 10.3389/fcvm.2022.811058
   Lederman O, 2017, AUSTRALAS PSYCHIATRY, V25, P451, DOI 10.1177/1039856217711054
   Lederman O, 2016, AUSTRALAS PSYCHIATRY, V24, P347, DOI 10.1177/1039856216632400
   Maurus I, 2021, EUR ARCH PSY CLIN N, V271, P315, DOI 10.1007/s00406-020-01175-2
   McLeroy KR, 2003, AM J PUBLIC HEALTH, V93, P529, DOI 10.2105/AJPH.93.4.529
   Norton K., 2011, PRE-EXERCISE SCREENING, Guide to the Australian adult pre-exercise screening system
   NSW Government, 2012, Metabolic Monitoring, New Mental Health Clinical Documentation Module
   Ostman C, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-017-0590-y
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Quirk H, 2020, EUR PSYCHIAT, V63, DOI 10.1192/j.eurpsy.2020.93
   Rosenbaum S, 2020, BMC PSYCHIATRY, V20, DOI 10.1186/s12888-020-2473-0
   Schuch FB, 2021, TRENDS PSYCHIATR PSY, V43, P177
   Soldevila-Matias P, 2023, FRONT PSYCHIATRY, V14, DOI 10.3389/fpsyt.2023.1204091
   Stewart G, 2010, AUST NZ J PSYCHIAT, V44, P258, DOI 10.3109/00048670903487175
   Tian DY, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/3756750
   Tomlinson-Perez S, 2022, BMC PUBLIC HEALTH, V22, DOI 10.1186/s12889-022-12638-7
   Turner-Stokes L, 2009, CLIN REHABIL, V23, P362, DOI 10.1177/0269215508101742
   Tweed LM, 2021, HEALTH PSYCHOL REV, V15, P287, DOI 10.1080/17437199.2020.1715812
   Vancampfort D, 2017, WORLD PSYCHIATRY, V16, P308, DOI 10.1002/wps.20458
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   von Elm E, 2007, LANCET, V370, P1453, DOI 10.1016/S0140-6736(07)61602-X
   Wheeler AJ, 2018, HEALTH SOC CARE COMM, V26, P860, DOI 10.1111/hsc.12597
NR 39
TC 0
Z9 0
U1 0
U2 0
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2731-4383
J9 DISCOV MENT HEALTH
JI Discov. Ment. Heatlh
PD NOV 11
PY 2024
VL 4
IS 1
AR 53
DI 10.1007/s44192-024-00110-4
PG 13
WC Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Psychiatry
GA L7H1P
UT WOS:001352381400001
PM 39527179
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Blanchard, CM
   Reid, RD
   Morrin, LI
   McDonnell, L
   McGannon, K
   Rhodes, RE
   Spence, JC
   Edwards, N
AF Blanchard, Chris M.
   Reid, Robert D.
   Morrin, Louise I.
   McDonnell, Lisa
   McGannon, Kerry
   Rhodes, Ryan E.
   Spence, John C.
   Edwards, Nancy
TI Demographic and Clinical Determinants of Moderate to Vigorous Physical
   Activity During Home-Based Cardiac Rehabilitation THE HOME-BASED
   DETERMINANTS OF EXERCISE (HOME) STUDY
SO JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
LA English
DT Article
DE home-based cardiac rehabilitation; patient characteristics; physical
   activity
ID METABOLIC SYNDROME; CORONARY; PROGRAM; DISEASE
AB PURPOSE: Little is known concerning moderate to vigorous physical activity (MVPA) levels in patients attending home-based cardiac rehabilitation (CR) programs and whether demographic/clinical characteristics moderate these levels.
   METHODS: Patients (N = 280, 77 female) who were referred to home-based CR, mainly because of myocardial infarction (34%), coronary artery bypass graft (17%), and percutaneous coronary intervention/stent/atherectomy (32%), completed a questionnaire assessing demographic and clinical characteristics as well as MVPA, measured at the beginning and end of a 3-month home-based CR program. Charts were reviewed for blood work, blood pressure, stress tests, and diagnosis.
   RESULTS: Patients averaged 88.5 minutes per week of MVPA before starting home-based CR, which increased to 191.1 minutes during the program. Multiple regression analyses showed that patients who were male (beta = -.11), did not have metabolic syndrome (beta = -.14), and were meeting the MVPA guideline before starting home-based CR (beta = .25) engaged in significantly more MVPA during home-based CR than their counterparts. Furthermore, the increase in MVPA was significantly larger for males (beta = -.20), patients without metabolic syndrome (beta = -.13), and patients who did not meet the MVPA guideline at baseline (beta = -.29) than their counterparts.
   CONCLUSIONS: The MVPA levels of patients attending home-based CR tend to vary depending on gender, whether or not metabolic syndrome was present, and prior MVPA levels, suggesting the need to potentially target these particular groups in future behavioral interventions aimed at increasing MVPA.
C1 [Blanchard, Chris M.] Clin Res Ctr, Halifax, NS B3H 1V7, Canada.
   [Reid, Robert D.; McDonnell, Lisa] Ottawa Heart Inst, Minto Prevent & Rehabil Ctr, Ottawa, ON, Canada.
   [Morrin, Louise I.] Calgary Hlth Reg Living Well Chron Condit Program, Calgary, AB, Canada.
   [Rhodes, Ryan E.] Univ Victoria, Fac Educ, Victoria, BC, Canada.
   [Spence, John C.] Univ Alberta, Fac Phys Educ & Recreat, Edmonton, AB, Canada.
   [Edwards, Nancy] Univ Ottawa, Sch Nursing, Ottawa, ON, Canada.
   [McGannon, Kerry] Univ Iowa, Dept Hlth & Sport Studies, Iowa City, IA USA.
C3 Dalhousie University; Dalhousie University Hospital; University of
   Ottawa; University of Ottawa Heart Institute; University of Victoria;
   University of Alberta; University of Ottawa; University of Iowa
RP Blanchard, CM (corresponding author), Clin Res Ctr, Room 205,5790 Univ Ave, Halifax, NS B3H 1V7, Canada.
EM chris.blanchard@dal.ca
RI Spence, John/D-1548-2009; Rhodes, Ryan/ABB-4896-2020; McGannon,
   Kerry/M-2213-2016
OI Spence, John C./0000-0001-8485-1336; Rhodes, Ryan/0000-0003-0940-9040;
   McGannon, Kerry/0000-0002-8614-697X; Edwards, Nancy/0000-0002-3117-5888
FU Social Sciences and Humanities Research Council of Canada; Canada
   Research Chair in Cardiovascular Disease and Physical Activity; CIHR;
   Canadian Health Services Research Foundation; Government of Ontario
FX This project was supported by a standard research grant from the Social
   Sciences and Humanities Research Council of Canada; Dr Blanchard is
   supported by a Canada Research Chair in Cardiovascular Disease and
   Physical Activity; and Dr Rhodes is supported by a CIHR New Investigator
   Award. Dr Edwards holds a Nursing Chair funded by the Canadian Health
   Services Research Foundation, the Canadian Institutes of Health
   Research, and the Government of Ontario.
CR ALLISON PD, 2003, J CARDIOPULM REHABIL, V23, P260
   Arthur HM, 2002, MED SCI SPORT EXER, V34, P1544, DOI 10.1097/00005768-200210000-00003
   Brien SE, 2006, APPL PHYSIOL NUTR ME, V31, P40, DOI 10.1139/H05-024
   Gayda M, 2008, NUTR METAB CARDIOVAS, V18, P142, DOI 10.1016/j.numecd.2006.07.003
   GODIN G, 1985, Canadian Journal of Applied Sport Sciences, V10, P141
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Hamer M, 2009, EUR J CARDIOV PREV R, V16, P156, DOI 10.1097/HJR.0b013e32831f1b77
   JACOBS DR, 1993, MED SCI SPORT EXER, V25, P81, DOI 10.1249/00005768-199301000-00012
   Jolly K, 2006, INT J CARDIOL, V111, P343, DOI 10.1016/j.ijcard.2005.11.002
   Oliveira J, 2008, J CARDIOPULM REHABIL, V28, P392, DOI 10.1097/HCR.0b013e31818c3b83
   Petter M, 2009, EUR J CARDIOV PREV R, V16, P515, DOI 10.1097/HJR.0b013e3283299585
   Reid RD, 2006, EUR J CARDIOV PREV R, V13, P529, DOI 10.1097/01.hjr.0000201513.13343.97
   Salvetti XM, 2008, CLIN REHABIL, V22, P987, DOI 10.1177/0269215508093331
   Smith SC, 2006, CIRCULATION, V113, P2363, DOI 10.1161/CIRCULATIONAHA.106.174516
NR 14
TC 36
Z9 38
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1932-7501
EI 1932-751X
J9 J CARDIOPULM REHABIL
JI J. Cardiopulm. Rehabil. Prev.
PD JUL-AUG
PY 2010
VL 30
IS 4
BP 240
EP 245
DI 10.1097/HCR.0b013e3181d0c4ae
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 626LI
UT WOS:000279967100005
PM 20216322
DA 2025-06-11
ER

PT J
AU Laudisio, A
   Bandinelli, S
   Gemma, A
   Ferrucci, L
   Incalzi, RA
AF Laudisio, Alice
   Bandinelli, Stefania
   Gemma, Antonella
   Ferrucci, Luigi
   Incalzi, Raffaele Antonelli
TI Metabolic syndrome and functional ability in older age: The InCHIANTI
   study
SO CLINICAL NUTRITION
LA English
DT Article
DE Metabolic syndrome; Disability; Elderly; Epidemiology
ID CARDIOVASCULAR RISK-FACTORS; BODY-MASS INDEX; REVERSE EPIDEMIOLOGY;
   HEART-FAILURE; ASSOCIATION; PREVALENCE; DISABILITY; MORTALITY;
   DEPRESSION; DECLINE
AB Background & aims: Metabolic syndrome (MetS) is associated with incident disability in middle-aged subjects. We evaluated the association of MetS with functional ability in an older population.
   Methods: We enrolled 1155 participants aged 65+, derived from the InCHIANTI study, and followed for 3 years. MetS was diagnosed according to the National Cholesterol Education Program's ATP-III criteria. Functional ability was estimated using the Katz's activities of daily living (ADLs), and the Lawton and Brody for the instrumental activities of daily living (IADLs) scales. The association between disability and MetS at baseline and after follow-up was assessed by logistic regression.
   Results: At baseline, MetS was associated with reduced probability of ADLs disability among participants aged 74+ (OR = .33, 95% CI = .14.77; p = .010), but not in younger (5.08, 95% CI = .88-29.24; p = .069). Also, MetS was associated with reduced probability of incident ADLs disability (OR = .61, 95% CI .41-.91; p = .016), but neither with prevalent, nor incident IADLs disability.
   Conclusions: In older persons, MetS is associated with reduced probability of prevalent and incident ADLs disability. Whether older persons with MetS should receive treatment and whether the current diagnostic criteria for MetS apply to older individuals need further investigation. (C) 2013 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Laudisio, Alice; Incalzi, Raffaele Antonelli] Campus Biomed Univ, Area Geriatria, I-00128 Rome, Italy.
   [Bandinelli, Stefania] Azienda Sanit Firenze, Geriatr Rehabil Unit, Florence, Italy.
   [Gemma, Antonella] Azienda Sanit Locale Roma E, UOS Accesso & Presa Car Assistenziale, Rome, Italy.
   [Ferrucci, Luigi] NIA, Longitudinal Studies Sect, Clin Res Branch, Baltimore, MD 21224 USA.
C3 University Campus Bio-Medico - Rome Italy; Azienda Sanitaria di Firenze;
   National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA)
RP Laudisio, A (corresponding author), Campus Biomed Univ, Area Geriatria, Via Alvaro del Portillo 200, I-00128 Rome, Italy.
EM lavoralice@gmail.com
RI Laudisio, Alice/AHI-1049-2022; Ferrucci, Luigi/AED-9724-2022;
   bandinelli, stefania/AAL-4570-2020; Incalzi, Raffaele/G-3978-2012
OI Ferrucci, Luigi/0000-0002-6273-1613; Laudisio,
   Alice/0000-0002-6167-053X; Antonelli Incalzi,
   Raffaele/0000-0003-2100-2075; Bandinelli, Stefania/0000-0002-6491-0850
FU Italian Ministry of Health [ICS110.1/RF97.71]; U.S. National Institute
   on Aging [263 MD 9164, 263 MD 821336]; InCHIANTI - U.S. National
   Institute on Aging [N.1-AG-1-1, N.1-AG-1-2111]
FX Support: The InCHIANTI study baseline (1998-2000) was supported as a
   targeted project (ICS110.1/RF97.71) by the Italian Ministry of Health
   and in part by the U.S. National Institute on Aging (Contracts 263 MD
   9164 and 263 MD 821336); the InCHIANTI Follow-Up 1 (2001-2003) was
   funded by the U.S. National Institute on Aging (Contracts N.1-AG-1-1 and
   N.1-AG-1-2111).
CR Akbaraly TN, 2010, DIABETES CARE, V33, P2339, DOI 10.2337/dc09-2200
   Bennett HP, 2002, J AM GERIATR SOC, V50, P1969, DOI 10.1046/j.1532-5415.2002.50608.x
   Cameron AJ, 2004, ENDOCRIN METAB CLIN, V33, P351, DOI 10.1016/j.ecl.2004.03.005
   Carrière I, 2011, J AFFECT DISORDERS, V133, P42, DOI 10.1016/j.jad.2011.03.020
   Clark AL, 2011, J CARD FAIL, V17, P374, DOI 10.1016/j.cardfail.2011.01.009
   DEYO RA, 1992, J CLIN EPIDEMIOL, V45, P613, DOI 10.1016/0895-4356(92)90133-8
   Ferrari P, 2002, PUBLIC HEALTH NUTR, V5, P1329, DOI 10.1079/PHN2002409
   Ferrucci L, 2000, J AM GERIATR SOC, V48, P1618, DOI 10.1111/j.1532-5415.2000.tb03873.x
   FOLSTEIN MF, 1975, J PSYCHIAT RES, V12, P189, DOI 10.1016/0022-3956(75)90026-6
   Freedman VA, 2002, JAMA-J AM MED ASSOC, V288, P3137, DOI 10.1001/jama.288.24.3137
   Fried TR, 2001, ARCH INTERN MED, V161, P2602, DOI 10.1001/archinte.161.21.2602
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Guralnik J.M., 1995, The women's health and aging study: Health and social characteristics of older women with disability
   Kalantar-Zadeh K, 2004, J AM COLL CARDIOL, V43, P1439, DOI 10.1016/j.jacc.2003.11.039
   Kalantar-Zadeh K, 2003, KIDNEY INT, V63, P793, DOI 10.1046/j.1523-1755.2003.00803.x
   KATZ S, 1963, JAMA-J AM MED ASSOC, V185, P914, DOI 10.1001/jama.1963.03060120024016
   Kawano Y, 2011, AM J HYPERTENS, V24, P1250, DOI 10.1038/ajh.2011.138
   Landi F, 2000, ARCH INTERN MED, V160, P2641, DOI 10.1001/archinte.160.17.2641
   LAWTON MP, 1969, GERONTOLOGIST, V9, P9, DOI 10.1093/geront/9.1.9
   Pisani P, 1997, INT J EPIDEMIOL, V26, pS152, DOI 10.1093/ije/26.suppl_1.S152
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Ravaglia G, 2006, DIABETES CARE, V29, P2471, DOI 10.2337/dc06-0282
   Roriz-Cruz M, 2007, J AM GERIATR SOC, V55, P374, DOI 10.1111/j.1532-5415.2007.01068.x
   Thomas GN, 2007, CLIN ENDOCRINOL, V66, P666, DOI 10.1111/j.1365-2265.2007.02798.x
   Virués-Ortega J, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-176
   Weiner MF, 2006, DEMENT GERIATR COGN, V22, P83, DOI 10.1159/000093388
   WHO Collaborating Centre for Drug Statistics Methodology, ATC DDD METH HIST
   Yang EF, 2012, METABOLISM, V61, P317, DOI 10.1016/j.metabol.2011.07.005
   Zingaretti MC, 2009, FASEB J, V23, P3113, DOI 10.1096/fj.09-133546
   Zuccalà G, 2005, AM J MED, V118, P496, DOI 10.1016/j.amjmed.2005.01.030
NR 30
TC 18
Z9 19
U1 0
U2 4
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD AUG
PY 2014
VL 33
IS 4
BP 626
EP 633
DI 10.1016/j.clnu.2013.08.005
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AL0IJ
UT WOS:000338810300009
PM 24035348
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Monteiro, R
   Azevedo, I
AF Monteiro, Rosario
   Azevedo, Isabel
TI Chronic Inflammation in Obesity and the Metabolic Syndrome
SO MEDIATORS OF INFLAMMATION
LA English
DT Review
ID C-REACTIVE PROTEIN; TUMOR-NECROSIS-FACTOR; COMMITTED SUBCUTANEOUS
   PREADIPOCYTES; ADIPOSE-TISSUE; INSULIN-RESISTANCE; WEIGHT-LOSS;
   SUBCLINICAL INFLAMMATION; FAT DISTRIBUTION; GUT MICROBIOTA; ADIPOCYTE
   SIZE
AB The increasing incidence of obesity and the metabolic syndrome is disturbing. The activation of inflammatory pathways, used normally as host defence response, reminds us of the seriousness of this condition. There is most probably more than one cause for the activation of inflammation, a timeline of events related to the deterioration of metabolic homeostasis presenting along variable routes. Apparently, metabolic overload evokes several stress reactions, such as oxidative, inflammatory, organelle, and cell hypertrophy stresses, generating vicious cycles that amplify each other leading to dysfunction. Adipocyte hypertrophy, through purely physical reasons, facilitates cell rupture, what will evoke an inflammatory reaction. Inability of adipose tissue development to engulf all incoming fat leads to fat deposition in other organs, mainly in the liver, with marked consequences on insulin resistance. The oxidative stress which accompanies feeding, particularly when there is an excessive ingestion of fat and/or other macronutrients without concomitant ingestion of antioxidant-rich foods/beverages, may contribute to the inflammatory markers attributed to obesity. Moreover, recent data on the microbiota and its interaction with food and with obesity brought new hypothetic mechanisms for the obesity/fat diet relationship with inflammation. Beyond these common confounders, other phenomena, for instance, psychological and/or circadian rhythm disturbances, may likewise contribute to the raise of oxidative/inflammatory status. The difficulty in the management of the obesity/metabolic syndrome pathologies is linked to their multifactorial nature where environmental, genetic, and psychosocial factors interact through highly complex networks.
C1 [Monteiro, Rosario; Azevedo, Isabel] Univ Porto, Fac Med, Dept Biochem FCT U38, P-4200319 Oporto, Portugal.
C3 Universidade do Porto
RP Monteiro, R (corresponding author), Univ Porto, Fac Med, Dept Biochem FCT U38, Al Prof Hernani Monteiro, P-4200319 Oporto, Portugal.
EM rosariom@med.up.pt
RI Monteiro, Rosário/R-1387-2018
OI Monteiro, Rosario/0000-0003-1552-5507
CR Aeberli I, 2008, INT J OBESITY, V32, P1513, DOI 10.1038/ijo.2008.128
   Aeberli I, 2006, AM J CLIN NUTR, V84, P748, DOI 10.1093/ajcn/84.4.748
   Aguilar-Salinas CA, 2008, J CLIN ENDOCR METAB, V93, P4075, DOI 10.1210/jc.2007-2724
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Alessi MC, 1997, DIABETES, V46, P860, DOI 10.2337/diabetes.46.5.860
   Alexaki VI, 2009, J IMMUNOL, V183, P5948, DOI 10.4049/jimmunol.0901186
   Alvarez JA, 2009, AM J CLIN NUTR, V89, P1138, DOI 10.3945/ajcn.2008.26926
   Armougom F, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007125
   Azevedo Ana, 2009, P1, DOI 10.1007/978-1-4020-9701-0_1
   Bacha F, 2003, J CLIN ENDOCR METAB, V88, P2534, DOI 10.1210/jc.2002-021267
   Bäckhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   Bahceci M, 2007, J ENDOCRINOL INVEST, V30, P210, DOI 10.1007/BF03347427
   Balkau B, 1999, DIABETIC MED, V16, P442
   Bastard JP, 2000, J CLIN ENDOCR METAB, V85, P3338, DOI 10.1210/jc.85.9.3338
   Baud V, 2001, TRENDS CELL BIOL, V11, P372, DOI 10.1016/S0962-8924(01)02064-5
   Bellingan GJ, 2002, J EXP MED, V196, P1515, DOI 10.1084/jem.20011794
   Bertorelle V, 2000, ENCEPHALE, V26, P3
   Beydoun MA, 2008, AM J CLIN NUTR, V87, P1914, DOI 10.1093/ajcn/87.6.1914
   Blackburn P, 2006, OBESITY, V14, P1747, DOI 10.1038/oby.2006.201
   Bochud M, 2009, J CLIN ENDOCR METAB, V94, P3969, DOI 10.1210/jc.2008-2428
   Burcelin R, 2009, FRONT BIOSCI-LANDMRK, V14, P5107, DOI 10.2741/3589
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Cani PD, 2009, CURR OPIN PHARMACOL, V9, P737, DOI 10.1016/j.coph.2009.06.016
   Cani PD, 2009, CURR PHARM DESIGN, V15, P1546, DOI 10.2174/138161209788168164
   Carnethon MR, 2004, DIABETES CARE, V27, P2707, DOI 10.2337/diacare.27.11.2707
   Caterson ID, 2004, CIRCULATION, V110, pE476, DOI 10.1161/01.CIR.0000140114.83145.59
   Chen SB, 2009, OBES SURG, V19, P461, DOI 10.1007/s11695-008-9619-3
   Cinti S, 2005, J LIPID RES, V46, P2347, DOI 10.1194/jlr.M500294-JLR200
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cnop M, 2002, DIABETES, V51, P1005, DOI 10.2337/diabetes.51.4.1005
   Cnop M, 2003, DIABETOLOGIA, V46, P459, DOI 10.1007/s00125-003-1074-z
   Cobb WS, 2005, J SURG RES, V129, P231, DOI 10.1016/j.jss.2005.06.015
   Dandona P, 1998, J CLIN ENDOCR METAB, V83, P2907, DOI 10.1210/jc.83.8.2907
   de Ferranti S, 2008, CLIN CHEM, V54, P945, DOI 10.1373/clinchem.2007.100156
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Ehrhart-Bornstein M, 2003, P NATL ACAD SCI USA, V100, P14211, DOI 10.1073/pnas.2336140100
   Einhorn Daniel, 2003, Endocr Pract, V9, P237
   Ferreira S, 2007, EUR J HEART FAIL, V9, P104, DOI 10.1016/j.ejheart.2006.10.004
   Frayn KN, 2003, INT J OBESITY, V27, P875, DOI 10.1038/sj.ijo.0802326
   Furuhashi M, 2004, J HYPERTENS, V22, P1977, DOI 10.1097/00004872-200410000-00021
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Gregor MF, 2007, J LIPID RES, V48, P1905, DOI 10.1194/jlr.R700007-JLR200
   Gustafson B, 2009, AM J PHYSIOL-ENDOC M, V297, pE999, DOI 10.1152/ajpendo.00377.2009
   Hassanali Z, 2010, DIABETES OBES METAB, V12, P139, DOI 10.1111/j.1463-1326.2009.01130.x
   Hausman GJ, 2004, J ANIM SCI, V82, P925
   Hayashi T, 2003, DIABETES CARE, V26, P650, DOI 10.2337/diacare.26.3.650
   Hegele RA, 2007, J LIPID RES, V48, P1433, DOI 10.1194/jlr.R700004-JLR200
   Heilbronn LK, 2001, ARTERIOSCL THROM VAS, V21, P968, DOI 10.1161/01.ATV.21.6.968
   Hoffmann JA, 1999, SCIENCE, V284, P1313, DOI 10.1126/science.284.5418.1313
   Hoppmann J, 2010, J ENDOCRINOL, V204, P153, DOI 10.1677/JOE-09-0292
   Hosogai N, 2007, DIABETES, V56, P901, DOI 10.2337/db06-0911
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Huynh MLN, 2002, J CLIN INVEST, V109, P41, DOI 10.1172/JCI11638
   Isakson P, 2009, DIABETES, V58, P1550, DOI 10.2337/db08-1770
   Katsuki A, 2003, DIABETES CARE, V26, P2341, DOI 10.2337/diacare.26.8.2341
   Kopp HP, 2005, INT J OBESITY, V29, P766, DOI 10.1038/sj.ijo.0802983
   Kopp HP, 2003, ARTERIOSCL THROM VAS, V23, P1042, DOI 10.1161/01.ATV.0000073313.16135.21
   Lafontan M, 2003, TRENDS PHARMACOL SCI, V24, P276, DOI 10.1016/S0165-6147(03)00132-9
   Lambert DM, 2005, OBES SURG, V15, P1225, DOI 10.1381/096089205774512546
   Lawrence T, 2007, INT J EXP PATHOL, V88, P85, DOI 10.1111/j.1365-2613.2006.00507.x
   Lee IS, 2010, ENDOCR J, V57, P39, DOI 10.1507/endocrj.K09E-046
   Ley RE, 2010, CURR OPIN GASTROEN, V26, P5, DOI 10.1097/MOG.0b013e328333d751
   Libby P, 2010, CIRC J, V74, P213, DOI 10.1253/circj.CJ-09-0706
   Martos R, 2009, METABOLISM, V58, P1153, DOI 10.1016/j.metabol.2009.03.017
   Medina-Gomez Gema, 2009, Endocrinol Nutr, V56, P404, DOI 10.1016/S1575-0922(09)72710-X
   Medzhitov R, 2008, NATURE, V454, P428, DOI 10.1038/nature07201
   Monteiro R, 2007, DIABETOLOGIA, V50, P1569, DOI 10.1007/s00125-007-0636-x
   Monteiro R, 2007, EUR J HEART FAIL, V9, P103, DOI 10.1016/j.ejheart.2006.10.010
   Monteiro R, 2009, OBESITY, V17, P937, DOI 10.1038/oby.2009.34
   Monteiro Rosario, 2009, P65, DOI 10.1007/978-1-4020-9701-0_4
   Monteiro R, 2006, OBES SURG, V16, P804, DOI 10.1381/096089206777346600
   Morris RC, 2006, J AM COLL NUTR, V25, p262S, DOI 10.1080/07315724.2006.10719576
   Mortensen OH, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007419
   Nicklas BJ, 2004, AM J CLIN NUTR, V79, P544
   Nieves DJ, 2003, DIABETES, V52, P172, DOI 10.2337/diabetes.52.1.172
   Nijhuis J, 2009, OBESITY, V17, P2014, DOI 10.1038/oby.2009.113
   Nishimura S, 2009, NAT MED, V15, P914, DOI 10.1038/nm.1964
   Okamoto Y, 2008, CIRC RES, V102, P218, DOI 10.1161/CIRCRESAHA.107.164988
   Ordovas JM, 2008, KIDNEY INT, V74, pS10, DOI 10.1038/ki.2008.517
   Orea Soler Isabel, 2010, Endocrinol Nutr, V57, P90, DOI 10.1016/j.endonu.2010.01.008
   Papathanasopoulos A, 2010, GASTROENTEROLOGY, V138, P65, DOI 10.1053/j.gastro.2009.11.045
   Parham MR, 2006, VET ECON, V47, P8
   Pasarica M, 2009, DIABETES, V58, P718, DOI 10.2337/db08-1098
   Peairs AT, 2008, OBESITY, V16, P1573, DOI 10.1038/oby.2008.252
   Qatanani M, 2007, GENE DEV, V21, P1443, DOI 10.1101/gad.1550907
   RAETZ CRH, 1990, ANNU REV BIOCHEM, V59, P129, DOI 10.1146/annurev.bi.59.070190.001021
   Rankin JW, 2007, J AM COLL NUTR, V26, P163, DOI 10.1080/07315724.2007.10719598
   Rattarasarn C, 2003, METABOLISM, V52, P1444, DOI 10.1016/S0026-0495(03)00257-9
   Roberge C, 2007, AM J PHYSIOL-ENDOC M, V293, pE1465, DOI 10.1152/ajpendo.00516.2007
   Rocha VZ, 2008, CIRC RES, V103, P467, DOI 10.1161/CIRCRESAHA.108.177105
   Rudich A, 2007, TRENDS ENDOCRIN MET, V18, P291, DOI 10.1016/j.tem.2007.08.006
   Santos AC, 2005, INT J OBESITY, V29, P1452, DOI 10.1038/sj.ijo.0803035
   Schäffler A, 2007, TRENDS IMMUNOL, V28, P393, DOI 10.1016/j.it.2007.07.003
   Schäffler A, 2006, ENDOCR REV, V27, P449, DOI 10.1210/er.2005-0022
   Serhan CN, 2007, ANNU REV IMMUNOL, V25, P101, DOI 10.1146/annurev.immunol.25.022106.141647
   Sethi JK, 2007, J LIPID RES, V48, P1253, DOI 10.1194/jlr.R700005-JLR200
   Shemesh T, 2007, INT J OBESITY, V31, P103, DOI 10.1038/sj.ijo.0803350
   Skurk T, 2005, EUR J ENDOCRINOL, V152, P863, DOI 10.1530/eje.1.01897
   Stefan N, 2008, ARCH INTERN MED, V168, P1609, DOI 10.1001/archinte.168.15.1609
   Tchoukalova Y, 2007, DIABETOLOGIA, V50, P151, DOI 10.1007/s00125-006-0496-9
   Troseid M, 2010, CARDIOVASC DIABETOL, V9, DOI 10.1186/1475-2840-9-11
   Uretsky S, 2007, AM J MED, V120, P863, DOI 10.1016/j.amjmed.2007.05.011
   van Dijk SJ, 2009, AM J CLIN NUTR, V90, P1656, DOI 10.3945/ajcn.2009.27792
   van Harmelen V, 2002, DIABETES, V51, P2029, DOI 10.2337/diabetes.51.7.2029
   Wagenknecht LE, 2003, DIABETES, V52, P2490, DOI 10.2337/diabetes.52.10.2490
   Wang B, 2008, J ENDOCRINOL, V198, P127, DOI 10.1677/JOE-08-0156
   Welsh P, 2010, J CLIN ENDOCR METAB, V95, P93, DOI 10.1210/jc.2009-1064
   Wildman RP, 2008, ARCH INTERN MED, V168, P1617, DOI 10.1001/archinte.168.15.1617
   Wildman RP, 2009, CURR OPIN CLIN NUTR, V12, P438, DOI 10.1097/MCO.0b013e32832c6db7
   Wilsgaard T, 2007, DIABETES RES CLIN PR, V78, P217, DOI 10.1016/j.diabres.2007.03.006
   Wolowczuk I, 2008, CLIN DEV IMMUNOL, P1, DOI 10.1155/2008/639803
   Wood IS, 2009, BIOCHEM BIOPH RES CO, V384, P105, DOI 10.1016/j.bbrc.2009.04.081
   Wymann MP, 2008, NAT REV MOL CELL BIO, V9, P162, DOI 10.1038/nrm2335
   You TJ, 2008, J GERONTOL A-BIOL, V63, P414, DOI 10.1093/gerona/63.4.414
   Ziccardi P, 2002, CIRCULATION, V105, P804, DOI 10.1161/hc0702.104279
   Zimmermann MB, 2008, INT J OBESITY, V32, pS11, DOI 10.1038/ijo.2008.202
NR 116
TC 847
Z9 977
U1 2
U2 69
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2010
VL 2010
AR 289645
DI 10.1155/2010/289645
PG 10
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA 640XE
UT WOS:000281086600001
PM 20706689
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Ziegler, MG
   Milic, M
AF Ziegler, Michael G.
   Milic, Milos
TI Sympathetic nerves and hypertension in stress, sleep apnea, and
   caregiving
SO CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
LA English
DT Review
DE epinephrine; norepinephrine; obesity; psychosocial; sleep
ID ELDERLY ALZHEIMER CAREGIVERS; POSITIVE AIRWAY PRESSURE; RESISTANT
   HYPERTENSION; BLOOD-PRESSURE; CATECHOLAMINERGIC SYSTEMS; HEART-RATE;
   EPINEPHRINE; PLASMA; RISK; INCREASES
AB Purpose of reviewThe sympathetic nervous system (SNS) mediates short-term increases in blood pressure. Evidence that psychosocial stress leads to chronic hypertension is mixed. The SNS activation found in obstructive sleep apnea (OSA), caregiving for a severely demented spouse, and obesity more specifically address whether SNS activation might lead to the metabolic syndrome and hypertension.Recent findingsObesity is associated with both increased SNS electrical activity and plasma norepinephrine. This is partly because of frequent OSA among the obese, but OSA does not fully explain SNS activation in obesity. Large stresses activate adrenal epinephrine release, but both animal and human studies indicate that epinephrine decreases aspects of the metabolic syndrome. On the other hand, norepinephrine is chronically elevated in OSA and among markedly stressed caregivers, and they have an increased incidence of hypertension. This is most striking in OSA, which causes a nocturnal diuresis. Hypertensive patients with OSA are resistant to the antihypertensive effects of diuretics, but respond to drugs that block SNS activity and the effects of renin.SummaryThe SNS may mediate chronic blood pressure increases in response to specific stresses and alter responses to therapy. Evidence linking psychosocial stress to hypertension is mixed.
C1 [Ziegler, Michael G.; Milic, Milos] Univ Calif San Diego, Sch Med, San Diego, CA 92103 USA.
C3 University of California System; University of California San Diego
RP Ziegler, MG (corresponding author), Univ Calif San Diego, Med Ctr, 200 W Arbor Dr, San Diego, CA 92103 USA.
EM mziegler@ucsd.edu
RI Ziegler, Michael/L-4728-2019
FU National Institutes of Health (NIH) [M01RR00827, RF1AG015301,
   UL1TR001442]
FX Funded in part by the National Institutes of Health (NIH) grants
   M01RR00827, RF1AG015301 and UL1TR001442.
CR Aprile DCB, 2016, AM J NEPHROL, V43, P206, DOI 10.1159/000445443
   Calhoun DA, 2004, CHEST, V125, P112, DOI 10.1378/chest.125.1.112
   CARSKADON MA, 1989, SLEEP, V12, P338, DOI 10.1093/sleep/12.4.338
   Cheezum MK, 2010, J CLIN SLEEP MED, V6, P190
   Cuffee Y, 2014, CURR HYPERTENS REP, V16, DOI 10.1007/s11906-014-0483-3
   Davis JT, 2012, J AM COLL CARDIOL, V59, P2206, DOI 10.1016/j.jacc.2012.02.040
   Elayan H, 2012, CELL MOL NEUROBIOL, V32, P871, DOI 10.1007/s10571-012-9819-1
   Esler M, 2001, AM J HYPERTENS, V14, p139S, DOI 10.1016/S0895-7061(01)02081-7
   Gaddam K, 2010, J HUM HYPERTENS, V24, P532, DOI 10.1038/jhh.2009.96
   Gentili A, 1996, EUR J CLIN PHARMACOL, V50, P463, DOI 10.1007/s002280050141
   Goldbart AD, 2010, CHEST, V138, P528, DOI 10.1378/chest.10-0150
   Gonçalves SC, 2007, CHEST, V132, P1858, DOI 10.1378/chest.07-1170
   Gonzaga CC, 2010, J CLIN SLEEP MED, V6, P363
   Grassi G, 2015, CIRC RES, V116, P976, DOI 10.1161/CIRCRESAHA.116.303604
   Grassi G, 2014, INT J CARDIOL, V177, P1020, DOI 10.1016/j.ijcard.2014.09.138
   Heitmann J, 2004, EUR RESPIR J, V23, P255, DOI 10.1183/09031936.04.00015604
   Kraiczi H, 2000, AM J RESP CRIT CARE, V161, P1423, DOI 10.1164/ajrccm.161.5.9909024
   Kvetnansky R, 2013, ADV PHARMACOL, V68, P359, DOI 10.1016/B978-0-12-411512-5.00017-8
   Kvetnansky R, 2009, PHYSIOL REV, V89, P535, DOI 10.1152/physrev.00042.2006
   Lambert GW, 2010, PHARMACOL THERAPEUT, V126, P159, DOI 10.1016/j.pharmthera.2010.02.002
   Lavie P, 2001, SLEEP, V24, P721, DOI 10.1093/sleep/24.6.721
   Logan AG, 2001, J HYPERTENS, V19, P2271, DOI 10.1097/00004872-200112000-00022
   Mausbach BT, 2008, PSYCHIAT RES, V160, P247, DOI 10.1016/j.psychres.2007.09.006
   Mills PJ, 1997, PSYCHOSOM MED, V59, P251, DOI 10.1097/00006842-199705000-00008
   Moller DS, 2003, AM J HYPERTENS, V16, P274, DOI 10.1016/S0895-7061(02)03267-3
   Nishizaka MK, 2005, CURR HYPERTENS REP, V7, P343, DOI 10.1007/s11906-005-0067-3
   O'Driscoll DM, 2011, SLEEP MED, V12, P483, DOI 10.1016/j.sleep.2010.09.015
   Pépin JL, 2010, AM J RESP CRIT CARE, V182, P954, DOI 10.1164/rccm.200912-1803OC
   Planès C, 1999, SLEEP, V22, P507, DOI 10.1093/sleep/22.4.507
   Roepke SK, 2012, STRESS, V15, P121, DOI 10.3109/10253890.2011.596866
   Ruttanaumpawan P, 2009, J HYPERTENS, V27, P1439, DOI 10.1097/HJH.0b013e32832af679
   Salo TM, 1999, EUR J CLIN PHARMACOL, V55, P191, DOI 10.1007/s002280050617
   Saxena AR, 2014, J HUM HYPERTENS, V28, P292, DOI 10.1038/jhh.2013.112
   Shaw WS, 1999, J PSYCHOSOM RES, V46, P215, DOI 10.1016/S0022-3999(98)00084-1
   Sparrenberger F, 2009, J HUM HYPERTENS, V23, P12, DOI 10.1038/jhh.2008.74
   Sun P, 2008, ANN NY ACAD SCI, V1148, P325, DOI 10.1196/annals.1410.078
   Tamisier R, 2015, SLEEP, V38, P1973, DOI 10.5665/sleep.5252
   von Känel R, 2010, GERONTOLOGY, V56, P41, DOI 10.1159/000264654
   Wang AX, 2014, J HYPERTENS, V32, P1600, DOI 10.1097/HJH.0000000000000230
   Zelveian PA, 2004, TERAPEVT ARKH, V76, P81
   Ziegler MG, 2001, CHEST, V120, P887, DOI 10.1378/chest.120.3.887
   ZIEGLER MG, 1976, NATURE, V261, P333, DOI 10.1038/261333a0
   Ziegler MG, 2012, CURR HYPERTENS REP, V14, P1, DOI 10.1007/s11906-011-0243-6
   Ziegler MG, 2011, AUTON NEUROSCI-BASIC, V162, P32, DOI 10.1016/j.autneu.2011.01.009
   Ziegler MG, 2011, CURR OPIN NEPHROL HY, V20, P50, DOI 10.1097/MNH.0b013e3283402eb5
NR 45
TC 18
Z9 20
U1 1
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1062-4821
EI 1473-6543
J9 CURR OPIN NEPHROL HY
JI Curr. Opin. Nephrol. Hypertens.
PD JAN
PY 2017
VL 26
IS 1
BP 26
EP 30
DI 10.1097/MNH.0000000000000288
PG 5
WC Urology & Nephrology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Urology & Nephrology; Cardiovascular System & Cardiology
GA EF3QI
UT WOS:000390238900005
PM 27755119
DA 2025-06-11
ER

PT J
AU de Melo, LGP
   Nunes, SOV
   Anderson, G
   Vargas, HO
   Barbosa, DS
   Galecki, P
   Carvalho, AF
   Maes, M
AF Piccoli de Melo, Luiz Gustavo
   Vargas Nunes, Sandra Odebrecht
   Anderson, George
   Vargas, Heber Odebrecht
   Barbosa, Decio Sabbattini
   Galecki, Piotr
   Carvalho, Andre F.
   Maes, Michael
TI Shared metabolic and immune-inflammatory, oxidative and nitrosative
   stress pathways in the metabolic syndrome and mood disorders
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Depressive disorders; Bipolar disorders; Inflammation; Metabolism;
   Oxidative stress; Leaky gut
ID MAJOR DEPRESSIVE DISORDER; NITRIC-OXIDE METABOLITES;
   CORONARY-ARTERY-DISEASE; C-REACTIVE PROTEIN; PLASMA URIC-ACID;
   IO-AND-NS; BIPOLAR-DISORDER; DOUBLE-BLIND; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE
AB This review examines the shared immune-inflammatory, oxidative and nitrosative stress (IO & NS) and metabolic pathways underpinning metabolic syndrome (MetS), bipolar disorder (BD) and major depressive disorder (MDD). Shared pathways in both MetS and mood disorders are low grade inflammation, including increased levels of pro-inflammatory cytokines and acute phase proteins, increased lipid peroxidation with formation of malondialdehyde and oxidized low density lipoprotein cholesterol (LDL-c), hypernitrosylation, lowered levels of antioxidants, most importantly zinc and paraoxonase (PON1), increased bacterial translocation (leaky gut), increased atherogenic index of plasma and Castelli risk indices; and reduced levels of high-density lipoprotein (HDL-c) cholesterol. Insulin resistance is probably not a major factor associated with mood disorders. Given the high levels of IO & NS and metabolic dysregulation in BD and MDD and the high comorbidity with the atherogenic components of the MetS, mood disorders should be viewed as systemic neuro-IO & NS-metabolic disorders. The IO & NS-metabolic biomarkers may have prognostic value and may contribute to the development of novel treatments targeting neuro-immune, neuro-oxidative and neuro-nitrosative pathways.
C1 [Piccoli de Melo, Luiz Gustavo; Vargas Nunes, Sandra Odebrecht; Vargas, Heber Odebrecht] Londrina State Univ UEL, Dept Clin Med, Hlth Sci Ctr, Londrina, Parana, Brazil.
   [Piccoli de Melo, Luiz Gustavo; Vargas Nunes, Sandra Odebrecht; Vargas, Heber Odebrecht] Univ Estadual Londrina, Univ Hosp, Ctr Approach & Treatment Smokers, Univ Campus, Londrina, Parana, Brazil.
   [Piccoli de Melo, Luiz Gustavo; Vargas Nunes, Sandra Odebrecht; Vargas, Heber Odebrecht; Barbosa, Decio Sabbattini; Maes, Michael] Univ Estadual Londrina, Hlth Sci Ctr, Hlth Sci Grad Program, Londrina, Parana, Brazil.
   [Anderson, George] CRC Scotland & London, London, England.
   [Barbosa, Decio Sabbattini] Univ Estadual Londrina, Dept Clin & Toxicol Anal, Londrina, Parana, Brazil.
   [Galecki, Piotr] Univ Lodz, Dept Adult Psychiat, Lodz, Poland.
   [Carvalho, Andre F.] Univ Fed Ceara, Dept Clin Med, Fac Med, Fortaleza, Ceara, Brazil.
   [Carvalho, Andre F.] Univ Fed Ceara, Translat Psychiat Res Grp, Fac Med, Fortaleza, Ceara, Brazil.
   [Maes, Michael] Chulalongkorn Univ, Dept Psychiat, Bangkok, Thailand.
   [Maes, Michael] Paisij Hilendarski Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria.
   [Maes, Michael] Revitalis, Waalre, Netherlands.
   [Maes, Michael] Deakin Univ, Impact Strateg Res Ctr, Geelong, Vic, Australia.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   University of Lodz; Universidade Federal do Ceara; Universidade Federal
   do Ceara; Chulalongkorn University; Plovdiv University; Deakin
   University
RP Maes, M (corresponding author), Chulalongkorn Univ, Dept Psychiat, Fac Med, Bangkok, Thailand.
EM dr.michaelmaes@hotmail.com
RI Maes, Michael/B-8546-2011; Carvalho, Andre/AEZ-4001-2022; de Melo, Luiz
   Gustavo Piccoli/C-2271-2018; Barbosa, Décio/AAE-6351-2019; Nunes,
   Sandra/B-4035-2019; Gałecki, Piotr/S-9594-2016; Anderson,
   George/AEO-3626-2022
OI Galecki, Piotr/0000-0003-2447-5636; Anderson,
   George/0000-0001-7243-0817; Maes, Michael/0000-0002-2012-871X; Melo,
   Luiz Gustavo Piccoli de/0000-0002-1078-8044; Odebrecht Vargas Nunes,
   Sandra/0000-0003-4851-6121
FU CNPq [470344/2013-0, 465928/2014-5]; CNPq (level II; Brazil)
FX The authors would like to acknowledge gratefully the Health Sciences
   Postgraduate Program at the State University of Londrina, Brazil. This
   work was supported by CNPq (grants numbers: 470344/2013-0 and
   465928/2014-5). AFC is supported by a research fellowship from CNPq
   (level II; Brazil).
CR Aboul-Fotouh S, 2013, PHARMACOL BIOCHEM BE, V104, P105, DOI 10.1016/j.pbb.2012.12.027
   Akhondzadeh S, 2006, BIPOLAR DISORD, V8, P485, DOI 10.1111/j.1399-5618.2006.00363.x
   Albert U, 2015, J AFFECT DISORDERS, V173, P170, DOI 10.1016/j.jad.2014.11.005
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Aldini G, 2007, MED RES REV, V27, P817, DOI 10.1002/med.20073
   Anderson G, 2016, CURR PHARM DESIGN, V22, P987, DOI 10.2174/1381612822666151214105314
   Anderson G, 2015, ADV INTEGR MED, V2, P31, DOI 10.1016/j.aimed.2014.12.007
   Anderson G, 2014, CURR PHARM DESIGN, V20, P3812, DOI 10.2174/13816128113196660738
   Anderson G, 2013, PHARMACOL REP, V65, P1647, DOI 10.1016/S1734-1140(13)71526-3
   Andreazza AC, 2008, J AFFECT DISORDERS, V111, P135, DOI 10.1016/j.jad.2008.04.013
   Andreazza AC, 2009, J PSYCHIATR NEUROSCI, V34
   Andreazza AC, 2007, J PSYCHIATR RES, V41, P523, DOI 10.1016/j.jpsychires.2006.07.013
   [Anonymous], CURR PHARM IN PRESS
   [Anonymous], METAB CLIN EXP
   [Anonymous], EFFECTS CIGARETTE SM
   [Anonymous], EFFECTS COQ10 SUPPLE
   [Anonymous], NEUROSCI
   [Anonymous], J AM COLL NUTR
   [Anonymous], ZINC PROTECTS APOPTO
   [Anonymous], METABOLIC SYNDROME O
   [Anonymous], CURR DIABET REP
   [Anonymous], INFLAMMATION IMPAIRE
   [Anonymous], ROLE TOLL RECEPTOR T
   [Anonymous], SYSTEMATIC REV ZINC
   [Anonymous], NEUROIMMUNE PATHOPHY
   [Anonymous], BIPOLAR DISORDER ROL
   [Anonymous], OXID MED CELL LONGEV
   [Anonymous], PSYCHOGERIATRICS
   [Anonymous], ASS OXIDATIVE STRESS
   [Anonymous], J DIABET METAB DISOR
   [Anonymous], ADENOSINE DEAMINASE
   Arenillas JF, 2007, STROKE, V38, P2196, DOI 10.1161/STROKEAHA.106.480004
   Aydemir Ö, 2014, REV BRAS PSIQUIATR, V36, P293, DOI 10.1590/1516-4446-2013-1299
   Baez-Duarte BG, 2016, METAB SYNDR RELAT D, V14, P154, DOI 10.1089/met.2015.0088
   Bagot RC, 2014, DIALOGUES CLIN NEURO, V16, P281
   Baldwin W, 2011, DIABETES, V60, P1258, DOI 10.2337/db10-0916
   Baliarsingh S, 2013, ARCH PHYSIOL BIOCHEM, V119, P27, DOI 10.3109/13813455.2012.732580
   Baptista T, 2004, METAB SYNDR RELAT D, V2, P290, DOI 10.1089/met.2004.2.290
   Baptista T, 2015, REV BRAS PSIQUIATR, V37, P106, DOI [S1516-44462015005041425, 10.1590/1516-4446-2014-1425]
   Barandas R, 2015, CURR PSYCHIAT REP, V17, DOI 10.1007/s11920-015-0637-2
   BECKING GC, 1967, CAN J BIOCHEM CELL B, V45, P1667, DOI 10.1139/o67-197
   Benton Tami, 2007, Ann Clin Psychiatry, V19, P289, DOI 10.1080/10401230701653542
   Berk M, 2011, NEUROSCI BIOBEHAV R, V35, P804, DOI 10.1016/j.neubiorev.2010.10.001
   Berk M, 2008, TRENDS PHARMACOL SCI, V29, P346, DOI 10.1016/j.tips.2008.05.001
   Berk M, 2013, TRENDS PHARMACOL SCI, V34, P167, DOI 10.1016/j.tips.2013.01.001
   Bond DJ, 2016, PSYCHONEUROENDOCRINO, V65, P76, DOI 10.1016/j.psyneuen.2015.12.012
   Bonnefont-Rousselot D, 2016, NUTRIENTS, V8, DOI 10.3390/nu8050250
   Bonomini F, 2015, AGING DIS, V6, P109, DOI 10.14336/AD.2014.0305
   Bortolasci CC, 2015, J AFFECT DISORDERS, V179, P148, DOI 10.1016/j.jad.2015.03.041
   Bortolasci CC, 2014, REDOX REP, V19, P232, DOI 10.1179/1351000214Y.0000000093
   Bortolato B, 2016, CURR MOL MED, V16, P119, DOI 10.2174/1566524016666160126144027
   Bortolato B, 2016, BMC MED, V14, DOI 10.1186/s12916-016-0560-3
   Bortolato B, 2015, CURR NEUROPHARMACOL, V13, P558, DOI 10.2174/1570159X13666150630171433
   Bot M, 2015, BIOL PSYCHIAT, V77, DOI 10.1016/j.biopsych.2015.10.023
   Boutagy NE, 2016, BIOCHIMIE, V124, P11, DOI 10.1016/j.biochi.2015.06.020
   Bragg Dee Ann Stults, 2015, FP Essent, V435, P17
   Cai ZJ, 1999, WHO TECH REP SER, V887, P1
   Caimi G, 2012, DIABETES METAB SYND, V6, P132, DOI 10.1016/j.dsx.2012.09.012
   Callaghan RC, 2014, J PSYCHIATR RES, V48, P102, DOI 10.1016/j.jpsychires.2013.09.014
   Capuron L, 2008, BIOL PSYCHIAT, V64, P896, DOI 10.1016/j.biopsych.2008.05.019
   Ceron JJ, 2014, BMC VET RES, V10, DOI 10.1186/1746-6148-10-74
   Chaddha A, 2015, CIRCULATION, V132, pE350, DOI 10.1161/CIRCULATIONAHA.114.015176
   Charalambous BM, 2007, SHOCK, V28, P15, DOI 10.1097/shk.0b013e318033ebc5
   Chaudhari K, 2010, INDIAN J CLIN BIOCHE, V25, P77, DOI 10.1007/s12291-010-0016-z
   Chen CC, 2008, METABOLISM, V57, P544, DOI 10.1016/j.metabol.2007.11.018
   Choi HK, 2007, AM J MED, V120, P442, DOI 10.1016/j.amjmed.2006.06.040
   Chu NF, 2000, EUR J EPIDEMIOL, V16, P13, DOI 10.1023/A:1007654507054
   Creta E, 2015, PHARMACOGENET GENOM, V25, P354, DOI 10.1097/FPC.0000000000000144
   Depner CM, 2014, CURR DIABETES REP, V14, DOI 10.1007/s11892-014-0507-z
   Di Minno MND, 2015, EXPERT OPIN DRUG SAF, V14, P1905, DOI 10.1517/14740338.2015.1111870
   Dik MG, 2007, DIABETES CARE, V30, P2655, DOI 10.2337/dc06-1190
   Dipnall JF, 2015, J AFFECT DISORDERS, V174, P215, DOI 10.1016/j.jad.2014.11.030
   Dixon JB, 2008, OBESITY, V16, P2010, DOI 10.1038/oby.2008.271
   Fabbrini E, 2014, DIABETES, V63, P976, DOI 10.2337/db13-1396
   FACCHINI F, 1991, JAMA-J AM MED ASSOC, V266, P3008, DOI 10.1001/jama.266.21.3008
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   Fearon IM, 2009, J MOL CELL CARDIOL, V47, P372, DOI 10.1016/j.yjmcc.2009.05.013
   Feng ZH, 2006, MUTAT RES-FUND MOL M, V601, P125, DOI 10.1016/j.mrfmmm.2006.06.003
   Fernandes BS, 2016, J CLIN PSYCHIAT, V77, pE457, DOI 10.4088/JCP.15r09984
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Galecki P, 2012, J AFFECT DISORDERS, V138, P360, DOI 10.1016/j.jad.2012.01.016
   Galecki P, 2009, PHARMACOL REP, V61, P436
   Gao C, 2015, AM J PHYSIOL-HEART C, V308, pH1583, DOI 10.1152/ajpheart.00346.2014
   Gao JH, 2013, NEUROL RES, V35, P844, DOI 10.1179/1743132813Y.0000000223
   Gao LG, 2012, ATHEROSCLEROSIS, V221, P311, DOI 10.1016/j.atherosclerosis.2011.10.027
   Gárate I, 2013, BIOL PSYCHIAT, V73, P32, DOI 10.1016/j.biopsych.2012.07.005
   Ghasemi A, 2013, ARCH IRAN MED, V16, P521, DOI 013169/AIM.008
   Ghayour-Mobarhan M, 2008, CLIN LAB, V54, P321
   Ghosh S, 2015, FOOD CHEM TOXICOL, V83, P111, DOI 10.1016/j.fct.2015.05.022
   Gibson KR, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-43
   Givertz MM, 2015, CIRCULATION, V131, P1763, DOI 10.1161/CIRCULATIONAHA.114.014536
   Goldsmith D. R., 2016, MOL PSYCHIAT
   Goldstein BI, 2009, J CLIN PSYCHIAT, V70, P1078, DOI 10.4088/JCP.08r04505
   Goldstein BI., 2015, Major Depressive Disorder and Bipolar Disorder Predispose Youth to Accelerated Atherosclerosis and Early Cardiovascular Disease: A Scientific Statement From the American Heart Association
   GONEN B, 1987, ATHEROSCLEROSIS, V65, P265, DOI 10.1016/0021-9150(87)90042-6
   Goszcz Katarzyna, 2015, Front Cardiovasc Med, V2, P29, DOI 10.3389/fcvm.2015.00029
   Gougol A, 2015, J PSYCHOPHARMACOL, V29, P575, DOI 10.1177/0269881115578160
   Gounopoulos P, 2007, Minerva Cardioangiol, V55, P821
   Grande I, 2012, PHYSIOL BEHAV, V106, P46, DOI 10.1016/j.physbeh.2011.10.029
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Guarner V, 2015, INTERD T GERONT GERI, V40, P99, DOI 10.1159/000364934
   Hämäläinen P, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-116
   Han SC, 2015, MEDIAT INFLAMM, V2015, DOI 10.1155/2015/720457
   Hayes JD, 1995, CRIT REV BIOCHEM MOL, V30, P445, DOI 10.3109/10409239509083491
   He BM, 2013, J CELL BIOCHEM, V114, P2431, DOI 10.1002/jcb.24581
   He Z, 2015, BRIT J NUTR, V113, P1355, DOI 10.1017/S000711451500077X
   Heffner JL, 2011, BIPOLAR DISORD, V13, P439, DOI 10.1111/j.1399-5618.2011.00943.x
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Hosseinzadeh-Attar MJ, 2016, J ENDOCRINOL INVEST, V39, P917, DOI 10.1007/s40618-016-0457-1
   HUANG HC, 1992, EUR J PHARMACOL, V221, P381
   Hulthe J, 2004, CLIN CHIM ACTA, V348, P1, DOI 10.1016/j.cccn.2004.05.021
   Itariu BK, 2014, GERONTOLOGY, V60, P189, DOI 10.1159/000356747
   Jacka FN, 2011, J SCI MED SPORT, V14, P222, DOI 10.1016/j.jsams.2010.10.458
   Jacka FN, 2012, J AFFECT DISORDERS, V141, P79, DOI 10.1016/j.jad.2012.02.018
   Jahangard L, 2014, EUR NEUROPSYCHOPHARM, V24, P1210, DOI 10.1016/j.euroneuro.2014.05.013
   Jamshidi L., 2014, Zahedan Journal of Research in Medical Sciences, V16, P55
   Jankovic A., 2016, BR J PHARM
   Jenner A, 2007, FREE RADICAL BIO MED, V42, P559, DOI 10.1016/j.freeradbiomed.2006.11.024
   Jéquier E, 2002, ANN NY ACAD SCI, V967, P379, DOI 10.1111/j.1749-6632.2002.tb04293.x
   Jiang MD, 2014, J AFFECT DISORDERS, V166, P22, DOI 10.1016/j.jad.2014.04.027
   Johnson RJ, 2013, DIABETES, V62, P3307, DOI 10.2337/db12-1814
   Jurenka JS, 2009, ALTERN MED REV, V14, P141
   Kakoti Bibhuti Bhusan, 2015, Front Cardiovasc Med, V2, P38, DOI 10.3389/fcvm.2015.00038
   Kametsu Yutaka, 2005, Tokai J Exp Clin Med, V30, P171
   Kan C, 2013, DIABETES CARE, V36, P480, DOI 10.2337/dc12-1442
   Karve AV, 2013, INDIAN J PHARMACOL, V45, P244, DOI 10.4103/0253-7613.111922
   Keane KN, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/181643
   Kemp DE, 2010, BIPOLAR DISORD, V12, P404, DOI 10.1111/j.1399-5618.2010.00823.x
   Khanzode SD, 2003, REDOX REP, V8, P365, DOI 10.1179/135100003225003393
   Khosravi-Boroujeni H, 2015, BMC PUBLIC HEALTH, V15, DOI 10.1186/s12889-015-2623-3
   Kikuchi K, 2012, INT J MOL SCI, V13, P7739, DOI 10.3390/ijms13067739
   Kim JI, 2015, MOL CELL BIOL, V35, P1686, DOI 10.1128/MCB.01321-14
   Kim YK, 2006, PROG NEURO-PSYCHOPH, V30, P1091, DOI 10.1016/j.pnpbp.2006.04.008
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Köhler O, 2016, AM J PSYCHIAT, V173, P807, DOI 10.1176/appi.ajp.2016.15040463
   Konrad D, 2014, PHYSIOLOGY, V29, P304, DOI 10.1152/physiol.00014.2014
   Kraakman MJ, 2015, CELL METAB, V21, P403, DOI 10.1016/j.cmet.2015.02.006
   Kulkarni SK, 2009, THESCIENTIFICWORLDJO, V9, P1233, DOI 10.1100/tsw.2009.137
   Kuno A, 2015, ANN NY ACAD SCI, V1348, P46, DOI 10.1111/nyas.12812
   Kupfer DJ, 2005, JAMA-J AM MED ASSOC, V293, P2528, DOI 10.1001/jama.293.20.2528
   Laakso M, 2014, NAT REV ENDOCRINOL, V10, P293, DOI 10.1038/nrendo.2014.29
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lanaspa MA, 2012, J BIOL CHEM, V287, P40732, DOI 10.1074/jbc.M112.399899
   Lasser K, 2000, JAMA-J AM MED ASSOC, V284, P2606, DOI 10.1001/jama.284.20.2606
   Leboyer M, 2012, J AFFECT DISORDERS, V141, P1, DOI 10.1016/j.jad.2011.12.049
   Lee KU, 2001, DIABETES RES CLIN PR, V54, pS29, DOI 10.1016/S0168-8227(01)00332-1
   Lee SR, 2015, KOREAN J PHYSIOL PHA, V19, P389, DOI 10.4196/kjpp.2015.19.5.389
   Lemche E, 2016, FRONT NEUROSCI-SWITZ, V10, DOI 10.3389/fnins.2016.00142
   Leo R, 2006, NEUROSCI LETT, V407, P211, DOI 10.1016/j.neulet.2006.08.043
   Leonard B, 2012, NEUROSCI BIOBEHAV R, V36, P764, DOI 10.1016/j.neubiorev.2011.12.005
   Lett HS, 2004, PSYCHOSOM MED, V66, P305, DOI 10.1097/01.psy.0000126207.43307.c0
   Liao TV, 2013, CURR TOP MED CHEM, V13, P2283, DOI 10.2174/15680266113136660160
   Libert S, 2011, CELL, V147, P1459, DOI 10.1016/j.cell.2011.10.054
   Lin PY, 2007, J CLIN PSYCHIAT, V68, P1056, DOI 10.4088/JCP.v68n0712
   Linsel-Nitschke P, 2005, NAT REV DRUG DISCOV, V4, P193, DOI 10.1038/nrd1658
   Lippi Giuseppe, 2010, Clin Cardiol, V33, pE76, DOI 10.1002/clc.20511
   Litvinova L, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00020
   Liu CS, 2014, CNS NEUROL DISORD-DR, V13, P1693
   Liu CS, 2013, ADV THER, V30, P987, DOI 10.1007/s12325-013-0067-7
   Liu S, 2016, BEHAV BRAIN RES, V302, P191, DOI 10.1016/j.bbr.2016.01.037
   Lomb DJ, 2010, BBA-PROTEINS PROTEOM, V1804, P1652, DOI 10.1016/j.bbapap.2009.11.021
   Lucas K, 2015, CNS NEUROL DISORD-DR, V14, P838, DOI 10.2174/1871527314666150317224645
   Lucas K, 2013, MOL NEUROBIOL, V48, P190, DOI 10.1007/s12035-013-8425-7
   Mabuchi H, 2007, ATHEROSCLEROSIS, V195, pE182, DOI 10.1016/j.atherosclerosis.2007.06.010
   Machado-Vieira R, 2008, J CLIN PSYCHIAT, V69, P1237, DOI 10.4088/JCP.v69n0806
   MAES M, 1995, PSYCHONEUROENDOCRINO, V20, P111, DOI 10.1016/0306-4530(94)00066-J
   Maes M, 2013, ACTA PSYCHIAT SCAND, V127, P344, DOI 10.1111/j.1600-0447.2012.01908.x
   Maes M, 1999, PSYCHOPHARMACOLOGY, V143, P401, DOI 10.1007/s002130050965
   Maes M, 1999, PSYCHONEUROENDOCRINO, V24, P371, DOI 10.1016/S0306-4530(98)00087-0
   Maes M, 1997, HORM RES, V48, P184, DOI 10.1159/000185511
   MAES M, 1994, AM J PSYCHIAT, V151, P112
   Maes M, 1998, ACTA PSYCHIAT SCAND, V98, P328, DOI 10.1111/j.1600-0447.1998.tb10092.x
   MAES M, 1991, J AFFECT DISORDERS, V23, P25, DOI 10.1016/0165-0327(91)90032-N
   Maes M, 1999, NEUROPSYCHOPHARMACOL, V20, P188, DOI 10.1016/S0893-133X(98)00058-X
   Maes M, 1999, BIOL PSYCHIAT, V45, P833, DOI 10.1016/S0006-3223(98)00131-0
   Maes M, 1997, ACTA PSYCHIAT SCAND, V95, P212, DOI 10.1111/j.1600-0447.1997.tb09622.x
   Maes MB, 2007, CLIN CHIM ACTA, V380, P31, DOI 10.1016/j.cca.2007.01.024
   Maes M, 2008, NEUROENDOCRINOL LETT, V29, P287
   Maes M, 2013, J AFFECT DISORDERS, V149, P23, DOI 10.1016/j.jad.2012.06.039
   Maes M, 2012, EXPERT OPIN THER TAR, V16, P1097, DOI 10.1517/14728222.2012.718331
   Maes M, 2011, NEUROENDOCRINOL LETT, V32, P133
   Maes M, 2011, PROG NEURO-PSYCHOPH, V35, P769, DOI 10.1016/j.pnpbp.2010.06.008
   Maes M, 2011, NEUROENDOCRINOL LETT, V32, P7
   Maes M, 2011, PROG NEURO-PSYCHOPH, V35, P659, DOI 10.1016/j.pnpbp.2011.02.019
   Maes M, 2010, J AFFECT DISORDERS, V125, P287, DOI 10.1016/j.jad.2009.12.014
   Maes M, 2009, CURR OPIN PSYCHIATR, V22, P75, DOI 10.1097/YCO.0b013e32831a4728
   Mallick S, 2014, J BIOL CHEM, V289, P35409, DOI 10.1074/jbc.M114.597575
   Mandal K, 2005, HANDB EXP PHARM, V170, P723
   Mansego ML, 2011, J HYPERTENS, V29, P492, DOI 10.1097/HJH.0b013e328341f1b2
   Mansur RB, 2015, NEUROSCI BIOBEHAV R, V52, P89, DOI 10.1016/j.neubiorev.2014.12.017
   Marchetti G, 1999, Cardiologia, V44, P633
   Martin-Subero M, 2016, CNS SPECTRUMS, V21, P184, DOI 10.1017/S1092852915000449
   Martina V, 2008, DIABETES CARE, V31, P940, DOI 10.2337/dc07-2251
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McEachin RC, 2010, BMC MED GENET, V11, DOI 10.1186/1471-2350-11-14
   McElroy SL, 2014, J CLIN PSYCHIAT, V75, P46, DOI [10.4088/JCP.13010tx4c, 10.4088/JCP.13r08634]
   McIntyre RS, 2012, ANN CLIN PSYCHIATRY, V24, P69
   McIntyre RS, 2010, CNS DRUGS, V24, P741, DOI 10.2165/11533280-000000000-00000
   Meng XZ, 2008, AM J PHYSIOL-CELL PH, V294, pC29, DOI 10.1152/ajpcell.00137.2007
   Menon Anil S, 2015, Indian J Endocrinol Metab, V19, P546, DOI 10.4103/2230-8210.163105
   Michel TM, 2007, PSYCHIAT RES, V151, P145, DOI 10.1016/j.psychres.2006.04.013
   Millán J, 2009, VASC HEALTH RISK MAN, V5, P757
   Miller AH, 2009, BIOL PSYCHIAT, V65, P732, DOI 10.1016/j.biopsych.2008.11.029
   Miyake T, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0107882
   Mokdad AH, 2003, JAMA-J AM MED ASSOC, V289, P76, DOI 10.1001/jama.289.1.76
   Molina-Hernández M, 2008, PROG NEURO-PSYCHOPH, V32, P1660, DOI 10.1016/j.pnpbp.2008.06.010
   Moreno-Indias I, 2016, TRANSL RES, V172, P6, DOI 10.1016/j.trsl.2016.01.002
   Morris G, 2015, BMC MED, V13, DOI 10.1186/s12916-015-0310-y
   Morris G, 2013, MOL NEUROBIOL, V48, P883, DOI 10.1007/s12035-013-8477-8
   Morris KC, 2011, J CEREBR BLOOD F MET, V31, P1003, DOI 10.1038/jcbfm.2010.229
   Mortuza R, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054514
   Motawi TK., 2016, MOL NEUROBIOL
   Moylan S, 2013, MOL PSYCHIATR, V18, P595, DOI 10.1038/mp.2012.33
   Moylan S, 2014, NEUROSCI BIOBEHAV R, V45, P46, DOI 10.1016/j.neubiorev.2014.05.007
   Muraca M, 2015, DISCOV MED, V19, P343
   MURPHY JM, 1987, ARCH GEN PSYCHIAT, V44, P473
   Murri MB, 2016, PSYCHONEUROENDOCRINO, V63, P327, DOI 10.1016/j.psyneuen.2015.10.014
   Myint AM, 2007, J AFFECT DISORDERS, V98, P143, DOI 10.1016/j.jad.2006.07.013
   Nasr Gamela, 2010, J Cardiovasc Dis Res, V1, P191, DOI 10.4103/0975-3583.74262
   Naumova AV, 2006, AM J PHYSIOL-HEART C, V290, pH837, DOI 10.1152/ajpheart.00831.2005
   Nicolaides NC, 2014, ANN NY ACAD SCI, V1318, P71, DOI 10.1111/nyas.12464
   Nowak G, 2005, PHARMACOL REP, V57, P713
   Ogino K, 2010, CIRC-HEART FAIL, V3, P73, DOI 10.1161/CIRCHEARTFAILURE.109.868604
   Onat A, 2006, AM J HYPERTENS, V19, P1055, DOI 10.1016/j.amjhyper.2006.02.014
   Onyedum Cajetan C, 2014, Indian J Endocrinol Metab, V18, P631, DOI 10.4103/2230-8210.139217
   Orozco-Solis R, 2014, NEUROSCIENCE, V264, P76, DOI 10.1016/j.neuroscience.2014.01.043
   Otto MCD, 2012, J NUTR, V142, P526, DOI 10.3945/jn.111.149781
   Özgür BG, 2015, PHARMACOL BIOCHEM BE, V138, P91, DOI 10.1016/j.pbb.2015.09.016
   Feoli AMP, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/587083
   Parikh NI, 2015, ATHEROSCLEROSIS, V239, P50, DOI 10.1016/j.atherosclerosis.2014.12.005
   Pasco JA, 2008, J AFFECT DISORDERS, V107, P221, DOI 10.1016/j.jad.2007.07.024
   Pavlov VA, 2012, NAT REV ENDOCRINOL, V8, P743, DOI 10.1038/nrendo.2012.189
   Pei HF, 2015, FREE RADICAL BIO MED, V82, P114, DOI 10.1016/j.freeradbiomed.2015.02.002
   de Castro MRP, 2015, J AFFECT DISORDERS, V172, P347, DOI 10.1016/j.jad.2014.10.023
   Raftery G, 2012, ARTHRITIS RES THER, V14, DOI 10.1186/ar4108
   Raj P, 2015, ANN NY ACAD SCI, V1348, P55, DOI 10.1111/nyas.12828
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   Redlich C, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/s12888-014-0348-y
   Robillard R, 2013, CURR PSYCHIAT REP, V15, DOI 10.1007/s11920-013-0402-3
   Ryo M, 2004, CIRC J, V68, P975, DOI 10.1253/circj.68.975
   Salagre E, 2016, J AFFECT DISORDERS, V200, P235, DOI 10.1016/j.jad.2016.04.047
   Sandek A, 2008, CURR OPIN CLIN NUTR, V11, P632, DOI 10.1097/MCO.0b013e32830a4c6e
   Sankhla M, 2012, CLIN LAB, V58, P385
   Sautin YY, 2008, NUCLEOS NUCLEOT NUCL, V27, P608, DOI 10.1080/15257770802138558
   Sentí M, 2003, J CLIN ENDOCR METAB, V88, P5422, DOI 10.1210/jc.2003-030648
   Shen HY, 2008, J AM COLL NUTR, V27, P577, DOI 10.1080/07315724.2008.10719741
   Shi JP, 2016, SCI REP-UK, V6, DOI 10.1038/srep24649
   Siervo M, 2014, J ALZHEIMERS DIS, V41, P151, DOI 10.3233/JAD-132279
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Solomon CG, 1997, AM J CLIN NUTR, V66, P1044, DOI 10.1093/ajcn/66.4.1044S
   Song C, 2011, PROG NEURO-PSYCHOPH, V35, P760, DOI 10.1016/j.pnpbp.2010.06.020
   Song J, 2016, FRONT CELL NEUROSCI, V10, DOI 10.3389/fncel.2016.00086
   SRIVASTAVA R, 1985, THROMB RES, V40, P413, DOI 10.1016/0049-3848(85)90276-2
   Steinerová A, 2001, PHYSIOL RES, V50, P131, DOI 10.33549/physiolres.930043
   Stetler C, 2011, PSYCHOSOM MED, V73, P114, DOI 10.1097/PSY.0b013e31820ad12b
   Stull LB, 2004, CIRC RES, V95, P1005, DOI 10.1161/01.RES.0000148635.73331.c5
   Szewczyk B, 2011, PROG NEURO-PSYCHOPH, V35, P693, DOI 10.1016/j.pnpbp.2010.02.010
   Takata K, 2014, CIRC J, V78, P2955, DOI 10.1253/circj.CJ-14-0638
   Talarowska M, 2016, PSYCHIAT CLIN NEUROS, V70, P100, DOI 10.1111/pcn.12370
   Talarowska M, 2012, NEUROSCI LETT, V510, P127, DOI 10.1016/j.neulet.2012.01.018
   Thomas C, 2008, PEDIATRICS, V121, pE1240, DOI 10.1542/peds.2007-2403
   Toalson Patrick, 2004, Prim Care Companion J Clin Psychiatry, V6, P152
   Treviño S, 2015, SYNAPSE, V69, P421, DOI 10.1002/syn.21832
   Treweeke AT, 2012, DIABETOLOGIA, V55, P2920, DOI 10.1007/s00125-012-2685-z
   Tu KY, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000002411
   Tucsek Z, 2014, J GERONTOL A-BIOL, V69, P1212, DOI 10.1093/gerona/glt177
   Tuttolomondo A, 2014, DRUG DES DEV THER, V8, P2221, DOI 10.2147/DDDT.S67655
   Vaarala O, 2000, LUPUS, V9, P202, DOI 10.1191/096120300678828280
   Valkanova V, 2013, J AFFECT DISORDERS, V150, P736, DOI 10.1016/j.jad.2013.06.004
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vancampfort D, 2013, AM J PSYCHIAT, V170, P265, DOI 10.1176/appi.ajp.2012.12050620
   Vargas HO, 2014, LIFE SCI, V102, P65, DOI 10.1016/j.lfs.2014.02.033
   Vargas HO, 2013, J AFFECT DISORDERS, V150, P923, DOI 10.1016/j.jad.2013.05.016
   Vargas HO, 2013, NEUROSCI LETT, V544, P136, DOI 10.1016/j.neulet.2013.03.059
   Nunes SOV, 2015, J AFFECT DISORDERS, V172, P55, DOI 10.1016/j.jad.2014.09.038
   Nunes SOV, 2013, ADDICT DISORD TREAT, V12, P158, DOI 10.1097/ADT.0b013e31827a63ff
   Nunes SOV, 2013, NEUROSCI BIOBEHAV R, V37, P1336, DOI 10.1016/j.neubiorev.2013.04.014
   Venkatesan N, 1998, BRIT J PHARMACOL, V124, P425, DOI 10.1038/sj.bjp.0701877
   Venturini D, 2012, OBESITY, V20, P2361, DOI 10.1038/oby.2012.130
   Viscogliosi G, 2016, AM J GERIAT PSYCHIAT, V24, P359, DOI 10.1016/j.jagp.2015.09.001
   Viscogliosi G, 2013, INT J GERIATR PSYCH, V28, P242, DOI 10.1002/gps.3817
   Vlaicu SI, 2016, IMMUNOL RES, V64, P653, DOI 10.1007/s12026-015-8783-5
   Vogelzangs N, 2011, J CLIN PSYCHIAT, V72, P598, DOI 10.4088/JCP.10m06559
   Volt H, 2016, J PINEAL RES, V60, P193, DOI 10.1111/jpi.12303
   Walker ER, 2015, JAMA PSYCHIAT, V72, P334, DOI 10.1001/jamapsychiatry.2014.2502
   Wan XY, 2016, J HEPATOL, V64, P925, DOI 10.1016/j.jhep.2015.11.022
   Wang QY, 2015, J HUAZHONG U SCI-MED, V35, P225, DOI 10.1007/s11596-015-1415-4
   Weiser M, 2014, BIPOLAR DISORD, V16, P441, DOI 10.1111/bdi.12202
   Wen SL, 2012, CLIN BIOCHEM, V45, P49, DOI 10.1016/j.clinbiochem.2011.10.010
   WHO, 2003, WHO TECH REP SER, V916, P1
   Williams LJ, 2009, J AFFECT DISORDERS, V118, P173, DOI 10.1016/j.jad.2009.02.001
   Wium-Andersen MK, 2016, BRIT J PSYCHIAT, V208, P138, DOI 10.1192/bjp.bp.114.150870
   Wongcharoen W, 2009, INT J CARDIOL, V133, P145, DOI 10.1016/j.ijcard.2009.01.073
   Wysokinski A, 2015, DIABETES METAB SYND, V9, P168, DOI 10.1016/j.dsx.2015.04.004
   Yang YK, 2015, CLIN CHIM ACTA, V450, P83, DOI 10.1016/j.cca.2015.08.002
   Yates KF, 2012, ARTERIOSCL THROM VAS, V32, P2060, DOI 10.1161/ATVBAHA.112.252759
   Ye JM, 2013, NEUROSCI LETT, V553, P72, DOI 10.1016/j.neulet.2013.08.020
   Zang Qun, 2007, Surg Infect (Larchmt), V8, P41, DOI 10.1089/sur.2006.033
   Zhang C, 2016, BRIT J PSYCHIAT, V208, P446, DOI 10.1192/bjp.bp.115.163790
NR 301
TC 131
Z9 134
U1 1
U2 42
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD AUG 1
PY 2017
VL 78
BP 34
EP 50
DI 10.1016/j.pnpbp.2017.04.027
PG 17
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA EY9HG
UT WOS:000404309100005
PM 28438472
DA 2025-06-11
ER

PT J
AU Hsu, YT
   Liao, CC
   Chang, SN
   Yang, YW
   Tsai, CH
   Chen, TL
   Sung, FC
AF Hsu, Yi-Ting
   Liao, Chien-Chang
   Chang, Shih-Ni
   Yang, Yu-Wan
   Tsai, Chon-Haw
   Chen, Ta-Liang
   Sung, Fung-Chang
TI Increased Risk of Depression in Patients with Parkinson Disease: A
   Nationwide Cohort Study
SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Article
DE Cohort study; depression; Parkinson disease
ID NEUROPSYCHIATRIC SYMPTOMS; METABOLIC SYNDROME; HEALTH; PREVALENCE;
   INEQUALITIES; HYPOTHESIS; DOPAMINE; REGISTER; DEMENTIA; DISORDER
AB Objective: The association between Parkinson disease (PD) and depression remains unclear, particularly in the Asian population. The purpose of this study is to investigate the risk of depression in patients with PD using population-based data. Methods: Based on the National Health Insurance Research Database of Taiwan, we identified 1,698 patients with PD aged 40 years or older diagnosed in 2000-2003. With frequency matching procedure, we randomly selected 6,792 subjects without PD stratified by sex and age. Both cohorts were followed until the end of 2008 or diagnosis of depression. Risk of depression associated with PD was estimated in the multivariate Cox hazards regressions. Diabetes, hypertension, and hyperlipidemia were more prevalent at baseline in patients with PD. Results: Compared with the cohort without PD, the hazard ratio (HR) for depression in PD patients was 4.06 (95% CI: 3.15-5.23), which increased to 4.26 (95% CI: 3.29-5.51) after adjustment for age, sex, urbanization, income, and coexisting medical conditions. In the sex stratification, the HR of depression for men with PD was 4.42 (95% CI: 2.93-6.67) compared with men without PD. The HR for the association between PD and depression in women was 4.22 (95% CI: 3.02-5.88). Conclusion: This study suggests that patients with PD are at an elevated risk of depression, particularly for men. Integrated care for early identification and treatment of depression are crucial for patients with PD.
C1 [Hsu, Yi-Ting; Yang, Yu-Wan; Tsai, Chon-Haw] China Med Univ Hosp, Neurosci Lab, Dept Neurol, Taichung, Taiwan.
   [Liao, Chien-Chang; Chang, Shih-Ni; Sung, Fung-Chang] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan.
   [Hsu, Yi-Ting; Yang, Yu-Wan; Tsai, Chon-Haw] China Med Univ, Sch Med, Taichung 404, Taiwan.
   [Liao, Chien-Chang] China Med Univ, Sch Chinese Med, Taichung 404, Taiwan.
   [Sung, Fung-Chang] China Med Univ, Dept Publ Hlth, Taichung 404, Taiwan.
   [Liao, Chien-Chang; Chen, Ta-Liang] Taipei Med Univ Hosp, Dept Anesthesiol, Taipei, Taiwan.
   [Liao, Chien-Chang; Chen, Ta-Liang] Taipei Med Univ, Sch Med, Taipei, Taiwan.
C3 China Medical University Taiwan; China Medical University Hospital -
   Taiwan; China Medical University Taiwan; China Medical University
   Hospital - Taiwan; China Medical University Taiwan; China Medical
   University Taiwan; China Medical University Taiwan; Taipei Medical
   University Hospital; Taipei Medical University; Taipei Medical
   University
RP Sung, FC (corresponding author), China Med Univ, Coll Publ Hlth, 91 Hsueh Shih Rd, Taichung 404, Taiwan.
EM fcsung@mail.cmu.edu.tw
RI Chang, Chun-Hung/AAT-1641-2021
OI Hsu, Yi-ting/0000-0002-8552-131X
FU Executive Yuan National Science Council [NSC 99-2314-B-039-016-MY2];
   China Medical University Hospital [DMR-99-176]; Taiwan Ministry of
   Health and Welfare Clinical Trial and Research Center of Excellence
   [MOHW103-TDU-Be212-113002]
FX The study was supported by grants from the Executive Yuan National
   Science Council (NSC 99-2314-B-039-016-MY2), China Medical University
   Hospital (DMR-99-176), and the Taiwan Ministry of Health and Welfare
   Clinical Trial and Research Center of Excellence
   (MOHW103-TDU-Be212-113002). Supporters had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   article.
CR Aarsland D, 2009, J NEUROL NEUROSUR PS, V80, P928, DOI 10.1136/jnnp.2008.166959
   Aarsland D, 2012, NAT REV NEUROL, V8, P35, DOI 10.1038/nrneurol.2011.189
   Barone P, 2009, MOVEMENT DISORD, V24, P1641, DOI 10.1002/mds.22643
   Becker C, 2011, EUR J NEUROL, V18, P448, DOI 10.1111/j.1468-1331.2010.03176.x
   Boorsma M, 2012, AM J GERIAT PSYCHIAT, V20, P932, DOI 10.1097/JGP.0b013e31825d08ac
   Cheng CL, 2011, PHARMACOEPIDEM DR S, V20, P236, DOI 10.1002/pds.2087
   Cheng TM, 2003, HEALTH AFFAIR, V22, P61, DOI 10.1377/hlthaff.22.3.61
   CUMMINGS JL, 1992, AM J PSYCHIAT, V149, P443
   FEIN O, 1995, J GEN INTERN MED, V10, P577, DOI 10.1007/BF02640369
   FIBIGER HC, 1984, CAN J NEUROL SCI, V11, P105, DOI 10.1017/S0317167100046230
   Findley L, 2003, MOVEMENT DISORD, V18, P1139, DOI 10.1002/mds.10507
   Frisina PG, 2009, PARKINSONISM RELAT D, V15, P144, DOI 10.1016/j.parkreldis.2008.04.038
   Hu G, 2008, NEUROLOGY, V70, P1972, DOI 10.1212/01.wnl.0000312511.62699.a8
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178, DOI 10.4088/JCP.v69n0202
   Kulisevsky J, 2008, MOVEMENT DISORD, V23, P1889, DOI 10.1002/mds.22246
   Leentjens AFG, 2003, MOVEMENT DISORD, V18, P414, DOI 10.1002/mds.10387
   Liao CC, 2013, ANN SURG, V257, P433, DOI 10.1097/SLA.0b013e31827b9b25
   Liao CC, 2012, J NEUROL NEUROSUR PS, V83, P1186, DOI 10.1136/jnnp-2012-302337
   Mackenbach JP, 2008, NEW ENGL J MED, V358, P2468, DOI 10.1056/NEJMsa0707519
   MARDER K, 1995, ARCH NEUROL-CHICAGO, V52, P695, DOI 10.1001/archneur.1995.00540310069018
   MAYEUX R, 1990, ADV NEUROL, V53, P163
   McDonald WA, 2003, BIOL PSYCHIAT, V54, P363, DOI 10.1016/S0006-3223(03)00530-4
   Nilsson FM, 2001, ACTA PSYCHIAT SCAND, V104, P380, DOI 10.1034/j.1600-0447.2001.00372.x
   Reijnders JSAM, 2008, MOVEMENT DISORD, V23, P183, DOI 10.1002/mds.21803
   Remy P, 2005, BRAIN, V128, P1314, DOI 10.1093/brain/awh445
   Richard Irene H, 2004, Cogn Behav Neurol, V17, P201
   Rod NH, 2013, EUR J NEUROL, V20, P663, DOI 10.1111/ene.12019
   Schrag A, 2001, PSYCHOL MED, V31, P65, DOI 10.1017/S0033291799003141
   Schuurman AG, 2002, NEUROLOGY, V58, P1501, DOI 10.1212/WNL.58.10.1501
   Simon KC, 2007, NEUROLOGY, V69, P1688, DOI 10.1212/01.wnl.0000271883.45010.8a
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Tandberg E, 1996, ARCH NEUROL-CHICAGO, V53, P175, DOI 10.1001/archneur.1996.00550020087019
   Willis GL, 2008, REV NEUROSCIENCE, V19, P245
NR 33
TC 32
Z9 35
U1 0
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1064-7481
EI 1545-7214
J9 AM J GERIAT PSYCHIAT
JI Am. J. Geriatr. Psychiatr.
PD SEP
PY 2015
VL 23
IS 9
BP 934
EP 940
DI 10.1016/j.jagp.2014.10.011
PG 7
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA CO8LI
UT WOS:000359420300007
PM 25529799
DA 2025-06-11
ER

PT J
AU Hirano, M
   Imagawa, A
   Totani, K
AF Hirano, Makoto
   Imagawa, Ayami
   Totani, Kiichiro
TI Stratified analysis of lectin-like chaperones in the folding disease
   related metabolic syndrome rat model
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Endoplasmic reticulum; Chaperone; Diabetes mellitus; Obesity; Protein
   interaction; Aggregation
ID ENDOPLASMIC-RETICULUM; QUALITY-CONTROL; DEGRADATION; OBESITY; ERP57
AB The metabolic syndrome including obesity and diabetes mellitus is known to be a major health problem worldwide. A recent study reported that obesity causes endoplasmic reticulum (ER) stress and subsequently leads to insulin resistance and type 2 diabetes. However, little is known about the alterations in the components of the calnexin/calreticulin (CNX/CRT) cycle, which promote glycoprotein folding in obese and diabetic conditions. To understand the operating status of the lectin-like chaperones related to the CNX/CRT cycle in the metabolic syndrome, we analyzed the chaperones for the activity, protein expression, and mRNA expression levels using Zucker fatty (ZF) and Zucker diabetic fatty (ZDF) rat models for obesity and diabetes, respectively. We demonstrated that misfolded proteins were gradually increased with progression of the syndrome, obesity to diabetes. The individual chaperone activities of CNX and CRT were both decreased in the ZF rat ER and, in contrast, were increased in the ZDF rat ER. The protein quantities and mRNA expressions of CNX and CRT were decreased in the ZF rats, but increased in the ZDF rats compared with those of the healthy model. Therefore, these results indicate that obesity down-regulates CNX and CRT expressions and their activities and diabetes up-regulates the expressions and activities of CNX and CRT. Our findings clearly suggest that metabolic syndrome affects the lectin-like chaperones in the CNX/CRT cycle at both the activity and expression levels. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Hirano, Makoto; Imagawa, Ayami; Totani, Kiichiro] Seikei Univ, Dept Mat & Life Sci, 3-3-1 Kichijoji Kita, Musashino, Tokyo 1808633, Japan.
C3 Seikei University
RP Totani, K (corresponding author), Seikei Univ, Dept Mat & Life Sci, 3-3-1 Kichijoji Kita, Musashino, Tokyo 1808633, Japan.
EM ktotani@st.seikei.ac.jp
RI Hirano, Makoto/G-8857-2016
OI Hirano, Makoto/0000-0001-5806-8639
FU Japan Society for the Promotion of Science (JSPS) [JP23681049,
   JP25560420, JP16H06290]; Grants-in-Aid for Scientific Research
   [16H06290] Funding Source: KAKEN
FX This work was financially supported by a Grant-in-Aid for Young
   Scientists (A) (No. JP23681049), a Grant-in-Aid for Challenging
   Exploratory Research (No. JP25560420), and a Grant-in-Aid for Specially
   Promoted Research (No. JP16H06290) from the Japan Society for the
   Promotion of Science (JSPS) to K.T.
CR Benyair R, 2011, INT REV CEL MOL BIO, V292, P197, DOI 10.1016/B978-0-12-386033-0.00005-0
   Francis E., 2002, CURR PROTOC CELL BIO, V15, P1
   Frickel EM, 2002, P NATL ACAD SCI USA, V99, P1954, DOI 10.1073/pnas.042699099
   Hebert DN, 2007, PHYSIOL REV, V87, P1377, DOI 10.1152/physrev.00050.2006
   Hebert DN, 1996, EMBO J, V15, P2961, DOI 10.1002/j.1460-2075.1996.tb00659.x
   Vera RH, 2012, ARTERIOSCL THROM VAS, V32, P2141, DOI 10.1161/ATVBAHA.112.255281
   Hirano M, 2015, BIOCHEM BIOPH RES CO, V456, P333, DOI 10.1016/j.bbrc.2014.11.081
   Lopes PA, 2011, PROSTAG LEUKOTR ESS, V85, P89, DOI 10.1016/j.plefa.2011.04.026
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Paracchini V, 2005, AM J EPIDEMIOL, V162, P101, DOI 10.1093/aje/kwi174
   Parodi AJ, 2000, BIOCHEM J, V348, P1, DOI 10.1042/0264-6021:3480001
   Peterson R.G., 1990, ILAR NEWS, V32, P16, DOI DOI 10.1093/ILAR.32.3.16
   Rutkevich LA, 2011, CURR OPIN CELL BIOL, V23, P157, DOI 10.1016/j.ceb.2010.10.011
   Silvennoinen L, 2004, J BIOL CHEM, V279, P13607, DOI 10.1074/jbc.M313054200
   Vora JP, 1996, J AM SOC NEPHROL, V7, P113
   ZUCKER LM, 1960, GENETICS, V45, P467
   ZUCKER LM, 1961, J HERED, V52, P275, DOI 10.1093/oxfordjournals.jhered.a107093
NR 17
TC 5
Z9 6
U1 0
U2 7
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD SEP 9
PY 2016
VL 478
IS 1
BP 247
EP 253
DI 10.1016/j.bbrc.2016.07.060
PG 7
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA DT2TF
UT WOS:000381332800038
PM 27425249
DA 2025-06-11
ER

PT J
AU Galeno, DML
   Carvalho, RP
   Boleti, APD
   Lima, AS
   de Almeida, PDO
   Pacheco, CC
   de Souza, TP
   Lima, ES
AF Lopes Galeno, Denise Morais
   Carvalho, Rosany Piccolotto
   de Araujo Boleti, Ana Paula
   Lima, Arleilson Sousa
   Oliveira de Almeida, Patricia Danielle
   Pacheco, Carolina Carvalho
   de Souza, Tatiane Pereira
   Lima, Emerson Silva
TI Extract from Eugenia punicifolia is an Antioxidant and Inhibits
   Enzymes Related to Metabolic Syndrome
SO APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
LA English
DT Article
DE Eugenia punicifolia; Antioxidant; Digestive enzymes; Metabolic syndrome;
   In vitro assay
ID ALPHA-GLUCOSIDASE; IN-VITRO; OXIDATIVE STRESS; L.
AB The present study aimed to investigate in vitro biological activities of extract of Eugenia punicifolia leaves (EEP), emphasizing the inhibitory activity of enzymes related to metabolic syndrome and its antioxidant effects. The antioxidant activity was analyzed by free radicals scavengers in vitro assays: DPPH center dot, ABTS(center dot+), O-2 (center dot-), and NO center dot and a cell-based assay. EEP were tested in inhibitory colorimetric assays using alpha-amylase, alpha-glucosidase, xanthine oxidase, and pancreatic lipase enzymes. The EEP exhibited activity in ABTS(center dot+), DPPH center dot, and O-2 (center dot-) scavenger (IC50 = 10.5 A +/- 1.2, 28.84 A +/- 0.54, and 38.12 A +/- 2.6 mu g/mL), respectively. EEP did not show cytotoxic effects, and it showed antioxidant activity in cells in a concentration-dependent manner. EEP exhibited inhibition of alpha-amylase, alpha-glucosidase, and xanthine oxidase activities in vitro assays (IC50 = 122.8 A +/- 6.3; 2.9 A +/- 0.1; 23.5 A +/- 2.6), respectively; however, EEP did not inhibit the lipase activity. The findings supported that extract of E. punicifolia leaves is a natural antioxidant and inhibitor of enzymes, such as alpha-amylase, alpha-glucosidase, and xanthine oxidase, which can result in a reduction in the carbohydrate absorption rate and decrease of risks factors of cardiovascular disease, thereby providing a novel dietary opportunity for the prevention of metabolic syndrome.
C1 [de Araujo Boleti, Ana Paula; Lima, Arleilson Sousa; Oliveira de Almeida, Patricia Danielle; Pacheco, Carolina Carvalho; de Souza, Tatiane Pereira; Lima, Emerson Silva] Univ Fed Amazonas, Fac Ciencias Farmaceut, BR-69010300 Manaus, Amazonas, Brazil.
   [Lopes Galeno, Denise Morais; Carvalho, Rosany Piccolotto] Univ Fed Amazonas, Dept Ciencias Fisiol, Inst Ciencias Biol, Lab Fisiol, BR-69010300 Manaus, Amazonas, Brazil.
C3 Universidade Federal de Amazonas; Universidade Federal de Amazonas
RP Lima, ES (corresponding author), Univ Fed Amazonas, Fac Ciencias Farmaceut, Rua Alexandre Amorim 330, BR-69010300 Manaus, Amazonas, Brazil.
EM morais_denise@hotmail.com; eslima@ufam.edu.br
RI Almeida, Patricia/MBV-8173-2025; de Souza, Tatiane/AAL-8078-2021; Silva
   Lima, Emerson/L-4553-2016; Araujo Boleti, Ana Paula/F-3433-2019
OI Silva Lima, Emerson/0000-0002-9367-2812; Araujo Boleti, Ana
   Paula/0000-0003-0253-8907; Galeno, Denise/0000-0001-8265-8698; Oliveira
   de Almeida, Patricia Danielle/0000-0002-2620-8251
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq);
   Fundacao de Amparo a Pesquisa do Estado do Amazonas (FAPEAM);
   DCR/CNPq/FAPEAM
FX The authors are grateful to Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq) and Fundacao de Amparo a Pesquisa do
   Estado do Amazonas (FAPEAM) for the financial support of this research.
   ESL is member of the INCT of Processes Redox in Biomedicina-Redoxoma
   (MCT/CNPq). APAB received a grant from DCR/CNPq/FAPEAM. Thanks to Celio
   Maia Chaves from EMBRAPA for the Eugenia punicifolia plant material
   donation and to Jim Hesson of AcademicEnglishSolutions.com for
   proofreading the English.
CR Adyanthaya I, 2010, J FOOD BIOCHEM, V34, P31, DOI 10.1111/j.1745-4514.2009.00257.x
   Ahmed F, 2009, J YOUNG PHARM, V1, P317, DOI 10.4103/0975-1483.59320
   Andrade-Cetto A, 2008, J ETHNOPHARMACOL, V116, P27, DOI 10.1016/j.jep.2007.10.031
   [Anonymous], 2000, US PHARM
   Apel K, 2004, ANNU REV PLANT BIOL, V55, P373, DOI 10.1146/annurev.arplant.55.031903.141701
   Bondet V, 1997, FOOD SCI TECHNOL-LEB, V30, P609
   Brunetti IL, 2006, PHARM BIOL, V44, P35, DOI 10.1080/13880200500530575
   Cai YZ, 2004, LIFE SCI, V74, P2157, DOI 10.1016/j.lfs.2003.09.047
   Espín JC, 2007, PHYTOCHEMISTRY, V68, P2986, DOI 10.1016/j.phytochem.2007.09.014
   Cefalu WT, 2008, AM J CLIN NUTR, V87, p481S, DOI 10.1093/ajcn/87.2.481S
   Consolini AE, 2002, J ETHNOPHARMACOL, V81, P57, DOI 10.1016/S0378-8741(02)00039-9
   Ervin R Bethene, 2009, Natl Health Stat Report, P1
   Floegel A, 2011, J FOOD COMPOS ANAL, V24, P1043, DOI 10.1016/j.jfca.2011.01.008
   Formica JV, 1995, FOOD CHEM TOXICOL, V33, P1061, DOI 10.1016/0278-6915(95)00077-1
   Govindarajan R, 2003, BIOL PHARM BULL, V26, P1424, DOI 10.1248/bpb.26.1424
   Halliwell B, 1997, NUTR REV, V55, pS44, DOI 10.1111/j.1753-4887.1997.tb06100.x
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Hartke K., 1987, DTSCH ARZNEIBUCH 9 K
   Heber D, 2007, J AGR FOOD CHEM, V55, P10050, DOI 10.1021/jf071689v
   Holvoet P, 2008, Verh K Acad Geneeskd Belg, V70, P193
   Hung HC, 2004, JNCI-J NATL CANCER I, V96, P1577, DOI 10.1093/jnci/djh296
   Ilhami G., 2010, FOOD CHEM TOXICOL, V48, P2227
   Kim SH, 2011, INT J MOL SCI, V12, P3757, DOI 10.3390/ijms12063757
   Lin CC, 2000, AM J CHINESE MED, V28, P87, DOI 10.1142/S0192415X00000118
   Mahmoudi M, 2009, AFR J BIOTECHNOL, V8, P7170
   Nakayama GR, 1997, J IMMUNOL METHODS, V204, P205, DOI 10.1016/S0022-1759(97)00043-4
   Öztürk M, 2007, FOOD CHEM, V103, P623, DOI 10.1016/j.foodchem.2006.09.005
   Re R, 1999, FREE RADICAL BIO MED, V26, P1231, DOI 10.1016/S0891-5849(98)00315-3
   RiceEvans CA, 1996, BIOCHEM SOC T, V24, P790, DOI 10.1042/bst0240790
   Shim YJ, 2003, J ETHNOPHARMACOL, V85, P283, DOI 10.1016/S0378-8741(02)00370-7
   Slanc P, 2009, PHYTOTHER RES, V23, P874, DOI 10.1002/ptr.2718
   Subramanian R, 2008, ACTA BIOCHIM POL, V55, P391, DOI 10.18388/abp.2008_3087
   van de Laar FA, 2005, DIABETES CARE, V28, P154, DOI 10.2337/diacare.28.1.154
   Voigt R., 2005, PHARM TECHNOLOGIE
   Wolfe KL, 2007, J AGR FOOD CHEM, V55, P8896, DOI 10.1021/jf0715166
   Zajácz A, 2007, CARBOHYD RES, V342, P717, DOI 10.1016/j.carres.2006.12.016
NR 36
TC 27
Z9 28
U1 0
U2 21
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0273-2289
EI 1559-0291
J9 APPL BIOCHEM BIOTECH
JI Appl. Biochem. Biotechnol.
PD JAN
PY 2014
VL 172
IS 1
BP 311
EP 324
DI 10.1007/s12010-013-0520-8
PG 14
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA AA3PQ
UT WOS:000331005200027
PM 24078187
DA 2025-06-11
ER

PT J
AU El-Fawal, R
   El Fayoumi, HM
   Mahmoud, MF
AF El-Fawal, Rania
   El Fayoumi, Hassan M.
   Mahmoud, Mona F.
TI Effects of diosmin and crocin on metabolic syndrome-associated
   cardio-vascular complications in rats
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Diosmin; Crocin; Metabolic syndrome; Vascular reactivity; Inflammation;
   ECG
ID GLYCATION END-PRODUCTS; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   ENDOTHELIAL DYSFUNCTION; ALLEVIATES HYPERTENSION; DOWN-REGULATION;
   SATIVUS L.; MODEL; INHIBITION; ANTIOXIDANT
AB This study aims to scrutinize the potential protective effect of diosmin and crocin against cardio-vascular complications attributed to metabolic syndrome (MS). For 16 weeks, the rats were given 10% fructose in water and 3% salt in diet to induce MS over a 16-week period. At week 7 and for 10 weeks, diosmin (50 mg/kg, PO) or crocin (50 mg/kg, PO) was administered daily. Non-invasive blood pressure (BP) was recorded in conscious animals. Thoracic aorta (macro vessels) and kidney (micro vessels) concentration-response curves for phenylephrine (PE) and acetylcholine (ACh) were analyzed. Electrocardiogram (ECG) parameters were recorded. Blood glucose level, serum insulin level, troponin T, advanced glycation end products (AGEs), malondialdehyde (MDA), and tumor necrosis factor-alpha (TNF-alpha) were measured. In addition, histological examination of aorta and heart tissues was performed. Diosmin and crocin alleviated cardio-vascular complications associated with MS. This is manifested in improvement of systolic and diastolic BP and ECG parameters. They ameliorated MS-induced exaggerated contractility to PE and improved the impaired dilatation to Ach in macro and micro vasculature. Diosmin and crocin reduced the elevated serum levels of insulin, AGEs, TNF-alpha, and MDA and reversed MS-induced structural changes of aorta and cardiac tissues. Diosmin and crocin offset the cardiac changes and vascular impairment associated with MS via attenuation of oxidative stress and suppression of inflammation.
C1 [El-Fawal, Rania; El Fayoumi, Hassan M.; Mahmoud, Mona F.] Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig 44519, Egypt.
   [El Fayoumi, Hassan M.] Sinai Univ Qantara, Fac Pharm, El Arish El Masaid, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Egyptian Knowledge
   Bank (EKB); Sinai University
RP Mahmoud, MF (corresponding author), Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig 44519, Egypt.
EM Mona_pharmacology@yahoo.com
RI Mahmoud, Mona/Q-8851-2019
OI Mahmoud, Mona/0000-0002-5312-2066
CR Ahmed S, 2016, INFLAMMATION, V39, P1783, DOI 10.1007/s10753-016-0413-4
   Akhondzadeh Shahin, 2004, BMC Complement Altern Med, V4, P12, DOI 10.1186/1472-6882-4-12
   Bacharova L, 2012, J ELECTROCARDIOL, V45, P244, DOI 10.1016/j.jelectrocard.2012.02.004
   Batchvarov I, 2010, J BIOMED CLIN RES, P3
   Baynes J.W., 1996, Current Opinion in Endocrinology, Diabetes and Obesity, V3, P277, DOI [https://doi.org/10.1097/00060793-199608000-00001, DOI 10.1097/00060793-199608000-00001]
   Benavente-García O, 2008, J AGR FOOD CHEM, V56, P6185, DOI 10.1021/jf8006568
   Cao W, 2017, LIFE SCI, V181, P9, DOI 10.1016/j.lfs.2017.05.021
   Chang-Liao WL, 2012, J ETHNOPHARMACOL, V141, P668, DOI 10.1016/j.jep.2011.08.001
   Chen Jun, 2007, Drug Discov Today Ther Strateg, V4, P93, DOI 10.1016/j.ddstr.2007.10.006
   Chrysant SG, 2015, CURR OPIN CARDIOL, V30, P383, DOI 10.1097/HCO.0000000000000189
   Dehghan F, 2016, SCI REP-UK, V6, DOI 10.1038/srep25139
   Del Rio D, 2005, NUTR METAB CARDIOVAS, V15, P316, DOI 10.1016/j.numecd.2005.05.003
   DI MASCIO P, 1991, AM J CLIN NUTR, V53, pS194, DOI 10.1093/ajcn/53.1.194S
   Ebrahimi F, 2019, AVICENNA J PHYTOMED
   El-Bassossy HM, 2015, TRANSL RES, V165, P621, DOI 10.1016/j.trsl.2014.11.008
   El-Bassossy HM, 2012, VASC PHARMACOL, V57, P194, DOI 10.1016/j.vph.2012.01.001
   El-Bassossy HM, 2011, FOOD CHEM TOXICOL, V49, P3007, DOI 10.1016/j.fct.2011.07.060
   El-Fawal R, 2018, BIOMED PHARMACOTHER, V102, P930, DOI 10.1016/j.biopha.2018.03.162
   Elosta A, 2012, CURR DIABETES REV, V8, P92, DOI 10.2174/157339912799424528
   Elsherbiny NM, 2016, CHEM-BIOL INTERACT, V247, P39, DOI 10.1016/j.cbi.2016.01.014
   Feidantsis K, 2016, CLIN NUTR ESPEN, V13
   Fukuzawa M, 1999, DIABETES RES CLIN PR, V43, P147, DOI 10.1016/S0168-8227(99)00005-4
   Goh SY, 2008, J CLIN ENDOCR METAB, V93, P1143, DOI 10.1210/jc.2007-1817
   Hassan NA, 2018, PHYTOMEDICINE, V43, P92, DOI 10.1016/j.phymed.2018.03.044
   Hassan NA, 2014, CHEM-BIOL INTERACT, V213, P28, DOI 10.1016/j.cbi.2014.01.019
   Heitzer T, 2001, CIRCULATION, V104, P2673, DOI 10.1161/hc4601.099485
   Heyun Wang, 2011, Frontiers of Chemical Science and Engineering, V5, P392, DOI 10.1007/s11705-011-1202-0
   Hotamisligil GS, 1996, SCIENCE, V271, P665, DOI 10.1126/science.271.5249.665
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jay D, 2006, FREE RADICAL BIO MED, V40, P183, DOI 10.1016/j.freeradbiomed.2005.06.018
   Kamata Katsuo, 2006, Journal of Smooth Muscle Research, V42, P159, DOI 10.1540/jsmr.42.159
   Kubota K, 1996, EUR J CLIN PHARMACOL, V49, P431, DOI 10.1007/s002280050046
   Li S., 2019, J. Food Bioact, V5, P43, DOI [DOI 10.31665/JFB.2019.5177, 10.31665/JFB.2019.5177]
   Liu N, 2005, APPL RADIAT ISOTOPES, V63, P151, DOI 10.1016/j.apradiso.2004.12.011
   Mancini A, 2014, J VASC RES, V51, P393, DOI 10.1159/000368930
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mendizábal Y, 2013, INT J HYPERTENS, V2013, DOI 10.1155/2013/230868
   Messerli Franz H, 2002, Curr Cardiol Rep, V4, P479, DOI 10.1007/s11886-002-0110-9
   Moreno V, 2010, J CARD FAIL, V16, P950, DOI 10.1016/j.cardfail.2010.07.245
   MORI T, 1995, BRIT J PHARMACOL, V116, P1668, DOI 10.1111/j.1476-5381.1995.tb16389.x
   Münzel T, 2010, EUR HEART J, V31, P2741, DOI 10.1093/eurheartj/ehq396
   Munir KM, 2013, AM J PHYSIOL-ENDOC M, V305, pE679, DOI 10.1152/ajpendo.00377.2013
   Nikbakht-Jam I, 2016, EUR J INTEGR MED, V8, P307, DOI 10.1016/j.eujim.2015.12.008
   Omland T, 2009, NEW ENGL J MED, V361, P2538, DOI 10.1056/NEJMoa0805299
   Oyenihi AB, 2014, INTECHOPEN
   Palatini P, 2004, CLIN EXP HYPERTENS, V26, P637, DOI 10.1081/CEH-200031959
   PAYKEL ES, 1982, J CLIN PSYCHOPHARM, V2, P14, DOI 10.1097/00004714-198202000-00004
   Pérez-Torres I, 2010, METABOLISM, V59, P414, DOI 10.1016/j.metabol.2009.08.014
   Potenza MA, 2005, AM J PHYSIOL-HEART C, V289, pH813, DOI 10.1152/ajpheart.00092.2005
   Queenthy SS, 2013, EUR J PHARMACOL, V718, P213, DOI 10.1016/j.ejphar.2013.08.031
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Sachdeva J, 2012, EXP TOXICOL PATHOL, V64, P557, DOI 10.1016/j.etp.2010.11.013
   Sampathkumar R, 2005, METABOLISM, V54, P1002, DOI 10.1016/j.metabol.2005.02.017
   Senthamizhselvan O, 2014, EUR J PHARMACOL, V736, P131, DOI 10.1016/j.ejphar.2014.04.026
   Sepahi S, 2018, AM J OPHTHALMOL, V190, P89, DOI 10.1016/j.ajo.2018.03.007
   Shabani S, 2018, BIOMED PHARMACOTHER, V108, P1376, DOI 10.1016/j.biopha.2018.09.127
   Shahmansouri N, 2014, J AFFECT DISORDERS, V155, P216, DOI 10.1016/j.jad.2013.11.003
   Shalkami AS, 2018, HUM EXP TOXICOL, V37, P78, DOI 10.1177/0960327117694075
   Sheng L, 2006, EUR J PHARMACOL, V543, P116, DOI 10.1016/j.ejphar.2006.05.038
   Shirali S, 2013, PHYTOTHER RES, V27, P1042, DOI 10.1002/ptr.4836
   Silambarasan T, 2012, EUR J PHARMACOL, V679, P81, DOI 10.1016/j.ejphar.2011.12.040
   Tack CJJ, 1996, DIABETES, V45, P15, DOI 10.2337/diabetes.45.1.15
   Yamagishi S, 2012, BBA-GEN SUBJECTS, V1820, P663, DOI 10.1016/j.bbagen.2011.03.014
   Zakaria EM, 2016, EUR J PHARMACOL, V791, P444, DOI 10.1016/j.ejphar.2016.09.008
NR 65
TC 10
Z9 11
U1 0
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD DEC
PY 2019
VL 392
IS 12
BP 1523
EP 1536
DI 10.1007/s00210-019-01700-8
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA JL8UB
UT WOS:000495801700005
PM 31352499
DA 2025-06-11
ER

PT J
AU Fraga, MC
   de Moura, EG
   Lima, ND
   Lisboa, PC
   de Oliveira, E
   Silva, JO
   Claudio-Neto, S
   Filgueiras, CC
   Abreu-Villaça, Y
   Manhaes, AC
AF Fraga, Mabel Carneiro
   de Moura, Egberto Gaspar
   Lima, Natalia da Silva
   Lisboa, Patricia C.
   de Oliveira, Elaine
   Silva, Juliana Oliveira
   Claudio-Neto, Sylvio
   Filgueiras, Claudio C.
   Abreu-Villaca, Yael
   Manhaes, Alex C.
TI Anxiety-like, novelty-seeking and memory/learning behavioral traits in
   male Wistar rats submitted to early weaning
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Early weaning; Anxiety; Novelty-seeking; Memory; Learning; Motor
   activity
ID ELEVATED PLUS-MAZE; MATERNAL PROLACTIN INHIBITION; LACTATION PROGRAMS;
   BODY-WEIGHT; CORTICOSTERONE RESPONSES; DEVELOPMENTAL PLASTICITY;
   NICOTINE CONSUMPTION; METABOLIC SYNDROME; LEPTIN RESISTANCE;
   SOCIAL-ISOLATION
AB The most frequently used animal models of early weaning (EW) in rodents, maternal deprivation and pharmacological inhibition of lactation, present confounding factors, such as high stress or drug side effects, that can mask or interact with the effects of milk deprivation per se. Given these limitations, the development of new models of EW may provide useful information regarding the impact of a shortened period of breastfeeding on the endocrine and nervous systems, both during development and at adulthood. Using a model of EW in which lactating Wistar rat dams are wrapped with a bandage to block access to milk during the last three days of lactation, we have recently shown that the adult offspring presented higher body mass, hyperphagia, hyperleptinemia, leptin as well as insulin resistance, and higher adrenal catecholamine content at adulthood. Here, we used this EW model, which involves no pharmacological treatment or maternal separation, to analyze anxiety-like, novelty-seeking and memory/learning behavioral traits in the adult male offspring. To that end, animals were tested in the elevated plus maze, in the hole board arena and in the radial arm water maze. Except for an increased number of rearing events (a measure of vertical activity), no other behavioral differences were observed between EW and control animals. The contrasting behavioral results between the three EW models may be associated with differences in HPA axis function in the offspring at weaning, since it has been observed that bandaging does not affect corticosteronemia while maternal separation and pharmacological EW increase it. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Fraga, Mabel Carneiro; Silva, Juliana Oliveira; Claudio-Neto, Sylvio; Filgueiras, Claudio C.; Abreu-Villaca, Yael; Manhaes, Alex C.] Univ Estado Rio de Janeiro, Inst Biol Roberto Alcantara Gomes, Dept Ciencias Fisiol, Ctr Biomed,Lab Neurofisiol, BR-20550170 Rio De Janeiro, RJ, Brazil.
   [Fraga, Mabel Carneiro; de Moura, Egberto Gaspar; Lima, Natalia da Silva; Lisboa, Patricia C.; de Oliveira, Elaine] Univ Estado Rio de Janeiro, Inst Biol Roberto Alcantara Gomes, Dept Ciencias Fisiol, Ctr Biomed,Lab Fisiol Endocrina, BR-20550170 Rio De Janeiro, RJ, Brazil.
C3 Universidade do Estado do Rio de Janeiro; Universidade do Estado do Rio
   de Janeiro
RP Manhaes, AC (corresponding author), Univ Estado Rio de Janeiro, Inst Biol Roberto Alcantara Gomes, Dept Ciencias Fisiol, Ctr Biomed,Lab Neurofisiol, Av Prof Manuel de Abreu 444,5 Andar, BR-20550170 Rio De Janeiro, RJ, Brazil.
EM amanhaes@uerj.br
RI Filgueiras, Claudio/MBG-9894-2025; Manhães, Alex/F-5499-2011;
   Abreu-Villaca, Yael/D-5997-2015; Neto, Sylvio/AAD-7517-2021; LIMA,
   NATALIA/K-5674-2015; Lisboa, Patricia/H-8336-2015; Moura,
   Egberto/H-1270-2012
OI Claudio Neto, Sylvio/0000-0002-2155-5983; Lisboa,
   Patricia/0000-0002-2477-4364; Abreu-Villaca, Yael/0000-0002-9801-6179;
   Manhaes, Alex C./0000-0003-4629-8343; Filgueiras,
   Claudio/0000-0003-4522-4799; Moura, Egberto/0000-0002-1159-7549
FU Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de
   Janeiro (FAPERJ); Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq); Sub-reitoria de Pos-graduacao e Pesquisa da
   Universidade do Estado do Rio de Janeiro (SR2-UERJ); Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
FX This work was supported by grants from: Fundacao Carlos Chagas Filho de
   Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ), Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) and
   Sub-reitoria de Pos-graduacao e Pesquisa da Universidade do Estado do
   Rio de Janeiro (SR2-UERJ). Authors ACM, CCF, EGM, PCB and YAV received
   fellowships from CNPq. Author MCF received a fellowship from FAPERJ.
   Authors NSL, JOS and SCN received scholarships from CNPq. Author SCN
   received a scholarship from Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior (CAPES).
CR Abreu-Villaça Y, 2006, BEHAV BRAIN RES, V167, P175, DOI 10.1016/j.bbr.2005.09.003
   [Anonymous], BREASTF VIT EM RESP
   Aoki MD, 2003, TISSUE CELL, V35, P143, DOI 10.1016/S0040-8166(03)00013-2
   Barker DJP, 2003, EUR J EPIDEMIOL, V18, P733, DOI 10.1023/A:1025388901248
   Bayne K, 1996, AM PHYS SOC PHYSL, V39, P208
   Bhatnagar S, 2005, HORM BEHAV, V47, P430, DOI 10.1016/j.yhbeh.2004.11.019
   Bonomo IT, 2008, J ENDOCRINOL, V198, P331, DOI 10.1677/JOE-07-0505
   Bonomo IT, 2007, J ENDOCRINOL, V192, P339, DOI 10.1677/joe.1.06952
   Bonomo IT, 2005, HORM METAB RES, V37, P220, DOI 10.1055/s-2005-861381
   Born R, 1977, Rev Med Suisse Romande, V97, P349
   BRUNELLI SA, 1989, DEV PSYCHOBIOL, V22, P295, DOI 10.1002/dev.420220308
   Byrnes EM, 2002, PHARMACOL BIOCHEM BE, V73, P869, DOI 10.1016/S0091-3057(02)00941-3
   Carola V, 2002, BEHAV BRAIN RES, V134, P49, DOI 10.1016/S0166-4328(01)00452-1
   Charney D.S., 1999, Neurobiology of mental illness, P494
   Chaves Roberto G., 2004, J. Pediatr. (Rio J.), V80, ps189, DOI 10.1590/S0021-75572004000700011
   COLE JC, 1994, PSYCHOPHARMACOLOGY, V114, P288, DOI 10.1007/BF02244851
   Dalla C, 2011, CURR TOP BEHAV NEURO, V8, P97, DOI 10.1007/7854_2010_94
   Darnaudéry M, 2008, BRAIN RES REV, V57, P571, DOI 10.1016/j.brainresrev.2007.11.004
   de Moura EG, 2008, NEUROIMMUNOMODULAT, V15, P176, DOI 10.1159/000153422
   de Moura EG, 2005, BIOSCIENCE REP, V25, P251, DOI 10.1007/s10540-005-2888-3
   de Moura EG, 2007, J NUTR BIOCHEM, V18, P134, DOI 10.1016/j.jnutbio.2006.04.002
   de Moura EG, 2009, J PHYSIOL-LONDON, V587, P4919, DOI 10.1113/jphysiol.2009.176289
   Dobryakova YV, 2006, B EXP BIOL MED+, V142, P161, DOI 10.1007/s10517-006-0316-8
   Eklund MB, 2006, BEHAV BRAIN RES, V172, P278, DOI 10.1016/j.bbr.2006.05.015
   Ellenbroek BA, 2005, STRESS, V8, P247, DOI 10.1080/10253890500404634
   Feldman R, 1998, CLIN PERINATOL, V25, P613, DOI 10.1016/S0095-5108(18)30101-5
   Figueiredo MS, 2012, NUTRITION, V28, P307, DOI 10.1016/j.nut.2011.07.002
   Fraga MC, 2011, PHARMACOL BIOCHEM BE, V100, P165, DOI 10.1016/j.pbb.2011.07.007
   Fraga-Marques MC, 2010, BEHAV BRAIN RES, V206, P147, DOI 10.1016/j.bbr.2009.08.029
   Fraga-Marques MC, 2009, HORM BEHAV, V55, P272, DOI 10.1016/j.yhbeh.2008.11.010
   Galtry J, 1997, Health Care Women Int, V18, P467
   Gluckman PD, 2007, J INTERN MED, V261, P461, DOI 10.1111/j.1365-2796.2007.01802.x
   Harder T, 2005, AM J EPIDEMIOL, V162, P397, DOI 10.1093/aje/kwi222
   Hohenshell LM, 2000, J ANIM SCI, V78, P38
   Ito A, 2006, BEHAV BRAIN RES, V171, P87, DOI 10.1016/j.bbr.2006.03.023
   JARRARD LE, 1993, BEHAV NEURAL BIOL, V60, P9, DOI 10.1016/0163-1047(93)90664-4
   Jeltsch H, 2004, PSYCHOPHARMACOLOGY, V175, P37, DOI 10.1007/s00213-004-1783-0
   Johnson NJT, 1996, PSYCHOPHARMACOLOGY, V124, P355, DOI 10.1007/BF02247441
   Kalinichev M, 2002, PHARMACOL BIOCHEM BE, V73, P131, DOI 10.1016/S0091-3057(02)00781-5
   Kanari K, 2005, BEHAV BRAIN RES, V156, P45, DOI 10.1016/j.bbr.2004.05.008
   Kikusui T, 2005, BEHAV BRAIN RES, V162, P200, DOI 10.1016/j.bbr.2005.03.013
   Kikusui T, 2006, BEHAV BRAIN RES, V175, P96, DOI 10.1016/j.bbr.2006.08.007
   Koike H, 2009, BEHAV BRAIN RES, V202, P114, DOI 10.1016/j.bbr.2009.03.028
   KOLLER WC, 1992, NEUROLOGY, V42, P33
   KOLLER WC, 1992, NEUROLOGY, V42, P57
   Kramer MS, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003517.pub2
   Larsen CM, 2012, BRAIN BEHAV IMMUN, V26, P201, DOI 10.1016/j.bbi.2011.07.233
   Léonhardt M, 2007, HORM BEHAV, V51, P77, DOI 10.1016/j.yhbeh.2006.08.008
   Levay EA, 2008, BEHAV BRAIN RES, V191, P164, DOI 10.1016/j.bbr.2008.03.021
   Lima NS, 2013, HORM METAB RES, V45, P22, DOI 10.1055/s-0032-1323703
   Lima ND, 2011, BRIT J NUTR, V105, P1405, DOI 10.1017/S0007114510005064
   Liu D, 2000, NAT NEUROSCI, V3, P799, DOI 10.1038/77702
   Liu D, 1997, SCIENCE, V277, P1659, DOI 10.1126/science.277.5332.1659
   Lomanowska AM, 2010, PHARMACOL BIOCHEM BE, V95, P100, DOI 10.1016/j.pbb.2009.12.013
   Manhaes AC, 2008, BEHAV BRAIN RES, V193, P216, DOI 10.1016/j.bbr.2008.05.018
   Mann P E, 2001, Prog Brain Res, V133, P251
   McCormick CM, 1998, INT J DEV NEUROSCI, V16, P175, DOI 10.1016/S0736-5748(98)00026-4
   McIntosh J, 1999, DEV BRAIN RES, V113, P97, DOI 10.1016/S0165-3806(99)00005-X
   McMurray RW, 2001, LUPUS, V10, P742, DOI 10.1191/096120301717164985
   MYERS MM, 1975, NEUROENDOCRINOLOGY, V19, P54, DOI 10.1159/000122425
   Oliveira LD, 2011, BEHAV PROCESS, V86, P75, DOI 10.1016/j.beproc.2010.09.005
   Ono M, 2008, NEUROSCIENCE, V156, P1103, DOI 10.1016/j.neuroscience.2008.07.078
   Passos MCF, 2000, NUTR RES, V20, P1603, DOI 10.1016/S0271-5317(00)00246-3
   Patel MS, 2011, ANN NUTR METAB, V58, P18, DOI 10.1159/000328040
   Patterson John P., 2005, Journal of Pharmacological and Toxicological Methods, V52, P159, DOI 10.1016/j.vascn.2005.05.003
   Pereira RO, 2006, REGUL PEPTIDES, V136, P117, DOI 10.1016/j.regpep.2006.05.002
   Pereira-da-Silva MS, 2009, BEHAV BRAIN RES, V205, P286, DOI 10.1016/j.bbr.2009.05.031
   Pilhatsch M, 2010, BEHAV BRAIN RES, V214, P187, DOI 10.1016/j.bbr.2010.05.016
   Poletto R, 2006, BRAIN RES, V1067, P36, DOI 10.1016/j.brainres.2005.10.001
   Rodgers RJ, 1997, BRAZ J MED BIOL RES, V30, P289, DOI 10.1590/S0100-879X1997000300002
   Rots NY, 1996, J NEUROENDOCRINOL, V8, P501, DOI 10.1046/j.1365-2826.1996.04843.x
   RUTTER M, 1991, J CHILD PSYCHOL PSYC, V32, P885, DOI 10.1111/j.1469-7610.1991.tb01916.x
   SHAH GV, 1988, ENDOCRINOLOGY, V122, P1883, DOI 10.1210/endo-122-5-1883
   Shepard JD, 2000, BRAIN RES, V861, P288, DOI 10.1016/S0006-8993(00)02019-9
   Shimozuru M, 2007, DEV PSYCHOBIOL, V49, P343, DOI 10.1002/dev.20202
   Simpson J, 2012, BEHAV BRAIN RES, V229, P289, DOI 10.1016/j.bbr.2011.12.036
   Stiller AL, 2011, PSYCHONEUROENDOCRINO, V36, P1383, DOI 10.1016/j.psyneuen.2011.03.012
   STRUPP BJ, 1995, J NUTR, V125, pS2221, DOI 10.1093/jn/125.suppl_8.2221S
   Suchecki D, 1997, AM J PHYSIOL-REG I, V273, pR1332, DOI 10.1152/ajpregu.1997.273.4.R1332
   Terranova ML, 2001, PHYSIOL BEHAV, V73, P393, DOI 10.1016/S0031-9384(01)00447-4
   Traissard N, 2007, NEUROPSYCHOPHARMACOL, V32, P851, DOI 10.1038/sj.npp.1301116
   VALZELLI L, 1973, PSYCHOPHARMACOLOGIA, V31, P305, DOI 10.1007/BF00421275
   Venero C, 2005, GENE DEV, V19, P2152, DOI 10.1101/gad.346105
   Vicente LL, 2004, NUTRITION, V20, P924, DOI 10.1016/j.nut.2004.06.014
   Viveros M P, 2009, Psychoneuroendocrinology, V34 Suppl 1, pS217, DOI 10.1016/j.psyneuen.2009.05.015
   Viveros MP, 2010, HORM BEHAV, V58, P808, DOI 10.1016/j.yhbeh.2010.08.003
   WAINWRIGHT P, 1989, DEV PSYCHOBIOL, V22, P183, DOI 10.1002/dev.420220208
   WELTI H, 1979, EUR J OBSTET GYN R B, V9, P35, DOI 10.1016/0028-2243(79)90043-1
   Workel JO, 2001, J NEUROENDOCRINOL, V13, P569, DOI 10.1046/j.1365-2826.2001.00668.x
   ZIMMERBERG B, 1992, PSYCHOPHARMACOLOGY, V106, P474, DOI 10.1007/BF02244817
NR 90
TC 16
Z9 18
U1 0
U2 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD JAN 30
PY 2014
VL 124
BP 100
EP 106
DI 10.1016/j.physbeh.2013.11.001
PG 7
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA AB0LA
UT WOS:000331482200014
PM 24246723
OA hybrid
DA 2025-06-11
ER

PT J
AU Murat, M
   Kutlu, Y
AF Murat, Merve
   Kutlu, Yasemin
TI Turkish Adaptation of the Health Improvement Profile for the Evaluation
   of Physical Well-Being of Individuals With Severe Mental Illness
SO FLORENCE NIGHTINGALE JOURNAL OF NURSING
LA English
DT Article
DE health promotion; physical examination; psychiatric nursing; severe
   mental disorders
ID MAJOR DEPRESSIVE DISORDER; BIPOLAR DISORDER; METABOLIC SYNDROME;
   SCHIZOPHRENIA; PEOPLE; ASSOCIATION; PREVALENCE; MORTALITY; BEHAVIOR;
   DIETARY
AB AIM: This study aimed to adopt the use of the Health Improvement Profile in the Turkish context and to report the findings obtained during its pilot implementation. METHODS: This descriptive cross-sectional study consisted of 280 individuals, and data were collected using the Patient and Disease Characteristics Form and the Health Improvement Profile between May and December 2019 & imath;n community mental health centers. The total content validity index of the Health Improvement Profile (Female-Male) was 0.97. RESULTS: Among the participants, 57.1% had a physical health problem, 58.1% had a diagnosis of a physical condition, and 41.9% had physical symptoms only. Intergroup comparisons showed that individuals diagnosed with schizophrenia and other psychotic disorders slept for less than 3 hours, individuals diagnosed with bipolar disorder consumed more alcohol, and individuals diagnosed with major depressive disorders slept for more than 8 hours, smoked more, consumed more caffeine, and practiced safe sex less consistently than individuals diagnosed with other psychiatric disorders (p < .05). CONCLUSION: The Health Improvement Profile is an assessment tool that psychiatric mental health nurses can use to evaluate the physical health of individuals diagnosed with serious mental illness. The use of Health Improvement Profile in routine practice may allow determining the redflagged parameters and provide an opportunity improving these parameters with evidence-based interventions.
C1 [Murat, Merve] Istanbul Univ Cerrahpasa, Inst Grad Studies, Istanbul, Turkiye.
   [Kutlu, Yasemin] Istanbul Univ Cerrahpasa, Florence Nightingale Fac Nursing, Dept Mental Hlth & Psychiat Nursing, Istanbul, Turkiye.
C3 Istanbul University - Cerrahpasa; Istanbul University - Cerrahpasa
RP Murat, M (corresponding author), Istanbul Univ Cerrahpasa, Inst Grad Studies, Istanbul, Turkiye.
EM murat.merve@yahoo.com
RI Kutlu, Yasemin/Q-6107-2017; MURAT MEHMED ALİ, MERVE/Q-8703-2018
FX Funding: The authors declared that this study has received no financial
   support.
CR Aci O., 2018, Ruh sagligi ve psikiyatri hemsireliginde fiziksel saglik, V1, P1
   Andrade C, 2019, J CLIN PSYCHIAT, V80, DOI 10.4088/JCP.19f12820
   Gonzalez-Torres MA, 2010, J SEX MED, V7, P3045, DOI 10.1111/j.1743-6109.2010.01795.x
   Ashour AA, 2019, ANN SAUDI MED, V39, P178, DOI 10.5144/0256-4947.2019.178
   Bly MJ, 2014, BIPOLAR DISORD, V16, P277, DOI 10.1111/bdi.12160
   Bollen K. A., 1989, STRUCTURAL EQUATIONS, DOI DOI 10.1002/9781118619179
   Bos D, 2022, J PSYCHIATR MENT HLT, V29, P86, DOI 10.1111/jpm.12748
   Bressington D, 2018, INT J MENT HEALTH NU, V27, P841, DOI 10.1111/inm.12373
   Bressington D, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/1471-244X-14-57
   Brown T, 2020, J PSYCHIATR MENT HLT, V27, P628, DOI 10.1111/jpm.12616
   Carpenter S, 2018, COMMUN METHODS MEAS, V12, P25, DOI 10.1080/19312458.2017.1396583
   Carson NJ, 2016, TRANSCULT PSYCHIATRY, V53, P595, DOI 10.1177/1363461516660901
   Challa F, 2021, BMC PSYCHIATRY, V21, DOI 10.1186/s12888-021-03631-2
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   Cuschieri S, 2019, SAUDI J ANAESTH, V13, P31, DOI 10.4103/sja.SJA_543_18
   Dadiomov D., 2020, Absolute addiction psychiatry review
   Davis A.J., 1992, APPL NURS RES, V5, P104, DOI [DOI 10.1016/S0897-1897(05)80008-4, 10.1016/s0897-1897(05)80008-4, 10.1016/s0897-1897]
   De Hert M, 2011, EUR PSYCHIAT, V26, P34, DOI 10.1016/j.eurpsy.2010.03.003
   Demir S., 2016, Medical Journal of Mustafa Kemal University, V7, P1
   Depp CA, 2014, BIPOLAR DISORD, V16, P422, DOI 10.1111/bdi.12200
   Dipasquale S, 2013, J PSYCHIATR RES, V47, P197, DOI 10.1016/j.jpsychires.2012.10.005
   Erie JC, 2014, AM J OPHTHALMOL, V158, P192, DOI 10.1016/j.ajo.2014.03.006
   Evans T.S., 2016, DISPARITIES SERIOUS
   Fentie D, 2023, BMC CARDIOVASC DISOR, V23, DOI 10.1186/s12872-023-03327-3
   Fuchs FD, 2020, HYPERTENSION, V75, P285, DOI 10.1161/HYPERTENSIONAHA.119.14240
   Gal G, 2017, CAN J PSYCHIAT, V62, P259, DOI 10.1177/0706743716666997
   General Directorate of Public Health, 2019, National cancer screening standards
   Gordon PC, 2013, NEUROPSYCH DIS TREAT, V9, P133, DOI 10.2147/NDT.S37019
   Gray R, 2009, INT J MENT HEALTH NU, V18, P299, DOI 10.1111/j.1447-0349.2009.00640.x
   Grover S, 2012, PSYCHIAT RES, V200, P1035, DOI 10.1016/j.psychres.2012.03.043
   Gurpegui M, 2012, PROG NEURO-PSYCHOPH, V37, P169, DOI 10.1016/j.pnpbp.2012.01.014
   Hosseini N, 2019, ALCOHOL ALCOHOLISM, V54, P408, DOI 10.1093/alcalc/agz036
   Hussain T, 2017, J CLIN DIAGN RES, V11, pVC05, DOI 10.7860/JCDR/2017/25801.10011
   Ji JG, 2013, SCHIZOPHRENIA BULL, V39, P527, DOI 10.1093/schbul/sbs065
   John AP, 2009, MED J AUSTRALIA, V190, P176, DOI 10.5694/j.1326-5377.2009.tb02342.x
   Kisa C, 2008, NEW S J, V46, P66
   Küçük L, 2018, ARCH PSYCHIAT NURS, V32, P194, DOI 10.1016/j.apnu.2017.10.015
   Lawrence D, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f2539
   Pengpid S, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16071251
   Pettersson D, 2020, EPIDEMIOL PSYCH SCI, V29, DOI 10.1017/S204579602000044X
   Pettipher A., 2015, BMJ Quality Improvement Reports, V4
   Radwan Ahmed, 2022, Nutrition and psychiatric disorders, P201, DOI 10.1007/978-981-19-5021-6_10
   de Barros FCR, 2014, CAD SAUDE PUBLICA, V30, P1195, DOI 10.1590/0102-311X00027113
   Shiers D. E., 2014, 2014 update Positive cardiometabolic Health Resource: An intervention framework for patients with psychosis and schizophrenia
   Shuel F, 2010, INT J NURS STUD, V47, P136, DOI 10.1016/j.ijnurstu.2009.06.003
   Sogi Girish M, 2020, Dent Res J (Isfahan), V17, P360
   Sugawara N, 2010, SCHIZOPHR RES, V123, P244, DOI 10.1016/j.schres.2010.08.030
   Thongsai S, 2016, J PSYCHIATR MENT HLT, V23, P255, DOI 10.1111/jpm.12300
   Vancampfort D, 2017, WORLD PSYCHIATRY, V16, P308, DOI 10.1002/wps.20458
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vos T, 2020, LANCET, V396, P1562
   Werkkala C, 2020, BMC PSYCHIATRY, V20, DOI 10.1186/s12888-020-02511-5
   White J, 2009, J PSYCHIATR MENT HLT, V16, P493, DOI 10.1111/j.1365-2850.2009.01375.x
   Wootten JC, 2022, CANCER EPIDEMIOL, V80, DOI 10.1016/j.canep.2022.102233
   Yalçin SU, 2019, ISSUES MENT HEALTH N, V40, P908, DOI 10.1080/01612840.2019.1619201
NR 55
TC 0
Z9 0
U1 0
U2 0
PU AVES
PI SISLI
PA BUYUKDERE CAD 105-9, MECIDIYEKOY, SISLI, ISTANBUL 34394, Turkiye
SN 2687-6442
J9 FLOR NIGHT J NURS
JI Florence Nightingale J. Nurs.
PD JUN
PY 2024
VL 32
IS 2
BP 168
EP 183
DI 10.5152/FNJN.2024.23085
PG 16
WC Nursing
WE Emerging Sources Citation Index (ESCI)
SC Nursing
GA XE7S2
UT WOS:001260078800008
PM 39552166
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bressington, D
   Badnapurkar, A
   Inoue, S
   Ma, HY
   Chien, WT
   Nelson, D
   Gray, R
AF Bressington, Daniel
   Badnapurkar, Ashish
   Inoue, Sachiko
   Ma, Hin Yeung
   Chien, Wai Tong
   Nelson, Deborah
   Gray, Richard
TI Physical Health Care for People with Severe Mental Illness: the
   Attitudes, Practices, and Training Needs of Nurses in Three Asian
   Countries
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE nurse attitudes; physical health care; severe mental illness; nurse
   education
ID METABOLIC SYNDROME; NURSING-STUDENTS; DISORDERS; SCHIZOPHRENIA;
   MORTALITY; KNOWLEDGE; RISK; PERCEPTIONS; DISPARITIES; QUALITY
AB People with severe mental illness (SMI) have considerable unmet physical health needs and an increased risk of early mortality. This cross-sectional survey utilized the Physical Health Attitude Scale (PHASe) to examine the attitudes, practices, and training needs of nurses towards physical health care of people with SMI in three Asian countries (Hong Kong, Japan, Qatar). Cross-country differences were explored and linear regression was used to investigate if nurses' attitudes and confidence were associated with their level of involvement in physical health care. A total of 481 questionnaires were returned. Hong Kong nurses were less involved in physical health care than those from Japan and Qatar. Nurses' attitudes and confidence were significant predictors of their participation in managing physical health. Compared with western countries, more nurses in this study felt that mental illness was a barrier to improving physical health. Three-quarters reported that they needed additional training in promoting cardiometabolic health. The perceived need for additional training in physical health care was held by Mental Health Nurses (MHN) irrespective of their type of nursing registration and nationality. Nurse educators and service providers should reconsider the physical health care training requirements of nurses working in mental health settings in order to improve the physical health of people with SMI.
C1 [Bressington, Daniel; Ma, Hin Yeung; Chien, Wai Tong] Hong Kong Polytech Univ, Sch Nursing, Kowloon, Hong Kong, Peoples R China.
   [Badnapurkar, Ashish] Hamad Med Corp, Hlth Serv & Populat Res Ctr, POB 3050, Doha, Qatar.
   [Inoue, Sachiko] Okayama Prefectural Univ, Dept Nursing, 111 Kuboki, Okayama 7191197, Japan.
   [Nelson, Deborah] Hamad Med Corp, Mental Hlth Serv, POB 3050, Doha, Qatar.
   [Gray, Richard] La Trobe Univ, Dept Nursing & Midwifery, Melbourne, Vic 3086, Australia.
C3 Hong Kong Polytechnic University; Hamad Medical Corporation; Okayama
   Prefectural University; Hamad Medical Corporation; La Trobe University
RP Bressington, D (corresponding author), Hong Kong Polytech Univ, Sch Nursing, Kowloon, Hong Kong, Peoples R China.
EM dan.bressington@polyu.edu.hk; ABadanapurkar@hamad.qa;
   sinoue@fhw.oka-pu.ac.jp; hin-yeung.ma@connect.polyu.hk;
   wai.tong.chien@polyu.edu.hk; DNelson@hamad.qa; r.gray@latrobe.edu.au
RI Chien, Wai Tong/M-6106-2019; Badanapurkar, Ashishkumar/AAW-7043-2020;
   Gray, Richard/C-9945-2017; Bressington, Daniel/G-2789-2017; Chien, Wai
   Tong/F-9604-2014
OI Badanapurkar, Ashishkumar/0000-0002-4668-2532; Gray,
   Richard/0000-0001-9694-4206; Inoue, Sachiko/0000-0003-1840-5631;
   Bressington, Daniel/0000-0003-0951-2208; Chien, Wai
   Tong/0000-0001-5321-5791
CR Aggarwal A, 2013, AM J PREV MED, V44, P392, DOI 10.1016/j.amepre.2012.12.006
   Berger J, 2015, J NURS ADMIN, V45, P600, DOI 10.1097/NNA.0000000000000272
   Bolton PS, 2016, J PSYCHOSOC NURS MEN, V54, P44, DOI 10.3928/02793695-20161026-01
   Bradshaw T, 2012, INT J MENT HEALTH NU, V21, P266, DOI 10.1111/j.1447-0349.2012.00818.x
   Bressington D, 2016, BMC PSYCHIATRY, V16, DOI 10.1186/s12888-016-1121-1
   Brown S, 2010, BRIT J PSYCHIAT, V196, P116, DOI 10.1192/bjp.bp.109.067512
   Chesney E, 2014, WORLD PSYCHIATRY, V13, P153, DOI 10.1002/wps.20128
   Colton Craig W, 2006, Prev Chronic Dis, V3, pA42
   Davidson S, 2001, AUST NZ J PSYCHIAT, V35, P196, DOI 10.1046/j.1440-1614.2001.00877.x
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   Gray R, 2017, INT J MENT HEALTH NU, V26, P32, DOI 10.1111/inm.12296
   Gray R, 2009, INT J MENT HEALTH NU, V18, P299, DOI 10.1111/j.1447-0349.2009.00640.x
   GREEN SB, 1991, MULTIVAR BEHAV RES, V26, P499, DOI 10.1207/s15327906mbr2603_7
   Haddad M, 2016, INT J MENT HEALTH NU, V25, P554, DOI 10.1111/inm.12246
   Happell B, 2013, NURS EDUC TODAY, V33, P396, DOI 10.1016/j.nedt.2013.01.015
   Happell Brenda, 2012, Issues Ment Health Nurs, V33, P752, DOI 10.3109/01612840.2012.708099
   Howard L, 2011, J PSYCHIATR MENT HLT, V18, P105, DOI 10.1111/j.1365-2850.2010.01642.x
   Hyland B, 2003, AUST NZ J PSYCHIAT, V37, P710, DOI 10.1111/j.1440-1614.2003.01264.x
   Jones S, 2008, ACTA PSYCHIAT SCAND, V118, P169, DOI 10.1111/j.1600-0447.2008.01211.x
   Kawashima A, 2004, NURS EDUC TODAY, V24, P286, DOI 10.1016/j.nedt.2004.02.001
   Knight M, 2017, ARCH PSYCHIAT NURS, V31, P447, DOI 10.1016/j.apnu.2017.07.001
   Mitchell AJ, 2015, ACTA PSYCHIAT SCAND, V132, P83, DOI 10.1111/acps.12466
   Mitchell AJ, 2010, J PSYCHOPHARMACOL, V24, P69, DOI 10.1177/1359786810382056
   Mitchell AJ, 2009, BRIT J PSYCHIAT, V194, P491, DOI 10.1192/bjp.bp.107.045732
   Morita Tatsuya, 2006, Am J Hosp Palliat Care, V23, P385, DOI 10.1177/1049909106292168
   Osborn DPJ, 2007, SOC PSYCH PSYCH EPID, V42, P787, DOI 10.1007/s00127-007-0247-3
   Pang SMC, 2003, NURS ETHICS, V10, P295, DOI 10.1191/0969733003ne607oa
   Ramjan LM, 2017, NURS EDUC TODAY, V53, P7, DOI 10.1016/j.nedt.2017.03.005
   Robson D, 2013, INT J MENT HEALTH NU, V22, P409, DOI 10.1111/j.1447-0349.2012.00883.x
   Robson D, 2012, INT J NURS STUD, V49, P72, DOI 10.1016/j.ijnurstu.2011.07.011
   Shefer G, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0111682
   Turale Sue, 2008, Nurse Educ Pract, V8, P1
   van Boekel LC, 2013, DRUG ALCOHOL DEPEN, V131, P23, DOI 10.1016/j.drugalcdep.2013.02.018
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   von Elm E, 2007, PLOS MED, V4, P1623, DOI [10.1371/journal.pmed.0040296, 10.1371/journal.pmed.0040297, 10.1016/S0140-6736(07)61602-X]
   Walker ER, 2015, JAMA PSYCHIAT, V72, P334, DOI 10.1001/jamapsychiatry.2014.2502
   Yokoyama M, 2016, J CLIN NURS, V25, P2478, DOI 10.1111/jocn.13270
NR 37
TC 35
Z9 38
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD FEB
PY 2018
VL 15
IS 2
AR 343
DI 10.3390/ijerph15020343
PG 14
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA FY3LM
UT WOS:000426721400168
PM 29462859
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Coole, JB
   Burr, SS
   Kay, AM
   Singh, JA
   Kondakala, S
   Yang, EJ
   Kaplan, BLF
   Howell, GE
   Stewart, JA
AF Coole, Jackson B.
   Burr, Stephanie S.
   Kay, Amber M.
   Singh, Jaime A.
   Kondakala, Sandeep
   Yang, Eun-Ju
   Kaplan, Barbara L. F.
   Howell, George E., III
   Stewart, James A., Jr.
TI Persistent organic pollutants (POPs) increase rage signaling to promote
   downstream cardiovascular remodeling
SO ENVIRONMENTAL TOXICOLOGY
LA English
DT Article
DE AGE-RAGE signaling; heart; oxidative stress; persistent organic
   pollutants; type 2 diabetes mellitus
ID GLYCATION END-PRODUCTS; MANGANESE SUPEROXIDE-DISMUTASE; METABOLIC
   SYNDROME; RECEPTOR; EXPOSURE; COLLAGEN; ACCUMULATION; EXPRESSION;
   LEPTIN; CELLS
AB Exposure to environmental contaminants and consumption of a high, saturated fatty diet has been demonstrated to promote precursors for metabolic syndrome (hyperglycemia, hyperinsulinemia, and hypertriglyceridemia). The purpose of this study was to determine if exposure to the most prevalent environmental persistent organic pollutants (POPs) would act as causative agents to promote metabolic syndrome independent of dietary intake. We hypothesized that POPs will activate the advanced glycated end-product (AGE)-and receptor for AGE (RAGE) signaling cascade to promote downstream signaling modulators of cardiovascular remodeling and oxidative stress in the heart. At 5-weeks of age nondiabetic (WT) and diabetic (ob/ob) mice were exposed POPs mixtures by oral gavage twice a week for 6-weeks. At the end of 6-weeks, animals were sacrificed and the hearts were taken for biochemical analysis. Increased activation of the AGE-RAGE signaling cascade via POPs exposure resulted in elevated levels of fibroblast differentiation (alpha-smooth muscle actin) and RAGE expression indicated maladaptive cardiac remodeling. Conversely, the observed decreased superoxide dismutase-1 and -2 (SOD-1 and SOD-2) expression may exacerbate the adverse changes occurring as a result of POPs treatment to reduce innate cardioprotective mechanisms. In comparison, ventricular collagen levels were decreased in mice exposed to POPs. In conclusion, exposure to organic environmental pollutants may intensify oxidative and inflammatory stressors to overwhelm protective mechanisms allowing for adverse cardiac remodeling.
C1 [Coole, Jackson B.] Mississippi State Univ, Coll Arts & Sci, Dept Biol Sci, Starkville, MS USA.
   [Burr, Stephanie S.; Kay, Amber M.; Stewart, James A., Jr.] Univ Mississippi, Sch Pharm, Dept Biomol Sci, Oxford, MS USA.
   [Singh, Jaime A.] Virginia Commonwealth Univ Hlth Syst, Richmond, VA USA.
   [Kondakala, Sandeep; Yang, Eun-Ju; Kaplan, Barbara L. F.; Howell, George E., III] Mississippi State Univ, Dept Basic Sci, Coll Vet Med, Starkville, MS USA.
C3 Mississippi State University; University of Mississippi; Virginia
   Commonwealth University; Mississippi State University
RP Stewart, JA (corresponding author), Univ Mississippi, Sch Pharm, Dept Biomol Sci, University, MS 38677 USA.
EM jastewa7@olemiss.edu
RI Kondakala, Sandeep/HGU-4505-2022
OI Kondakala, Sandeep/0000-0003-3958-7104; Coole,
   Jackson/0000-0002-8821-4139; Kaplan, Barbara/0000-0002-1992-4145
FU Mississippi State University Department of Biological Sciences;
   Mississippi State University Shackoul's Honors College; Office of
   Research and Graduate Studies at the Mississippi State University
   College of Veterinary Medicine; University of Mississippi School of
   Pharmacy; Department of BioMolecular Sciences
FX Mississippi State University Department of Biological Sciences;
   Mississippi State University Shackoul's Honors College; Office of
   Research and Graduate Studies at the Mississippi State University
   College of Veterinary Medicine; University of Mississippi School of
   Pharmacy; Department of BioMolecular Sciences
CR Badenhorst D, 2003, CARDIOVASC RES, V57, P632, DOI 10.1016/S0008-6363(02)00733-2
   Banerjee I, 2006, ANN NY ACAD SCI, V1080, P76, DOI 10.1196/annals.1380.007
   Banerjee I, 2007, AM J PHYSIOL-HEART C, V293, pH1883, DOI 10.1152/ajpheart.00514.2007
   Bartels ED, 2010, ENDOCRINOLOGY, V151, P5218, DOI 10.1210/en.2010-0355
   Bigot N, 2012, J INVEST DERMATOL, V132, P2360, DOI 10.1038/jid.2012.164
   Cassese A, 2008, J BIOL CHEM, V283, P36088, DOI 10.1074/jbc.M801698200
   Chen JF, 2016, AM J TRANSL RES, V8, P2169
   Ferri N, 2003, J BIOL CHEM, V278, P19757, DOI 10.1074/jbc.M212714200
   Giacco F, 2010, CIRC RES, V107, P1058, DOI 10.1161/CIRCRESAHA.110.223545
   Hamada Y, 1996, BIOCHEM BIOPH RES CO, V228, P539, DOI 10.1006/bbrc.1996.1695
   Han D, 2013, GENES CELLS, V18, P302, DOI 10.1111/gtc.12036
   Howell GE, 2014, TOXICOLOGY, V320, P6, DOI 10.1016/j.tox.2014.02.004
   Hozhabri NST, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0113334
   Hutchinson KR, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0072080
   Ibrahim MM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025170
   Iversen MB, 2016, FREE RADICAL BIO MED, V97, P478, DOI 10.1016/j.freeradbiomed.2016.07.004
   Jones KC, 1999, ENVIRON POLLUT, V100, P209, DOI 10.1016/S0269-7491(99)00098-6
   Kliment CR, 2009, THESIS
   Lee DH, 2008, DIABETOLOGIA, V51, P402, DOI 10.1007/s00125-007-0896-5
   Lee DH, 2007, DIABETOLOGIA, V50, P1841, DOI 10.1007/s00125-007-0755-4
   Lind YS, 2013, ENVIRON RES, V123, P39, DOI 10.1016/j.envres.2013.02.007
   Lind YS, 2013, J HYPERTENS, V31, P1547, DOI 10.1097/HJH.0b013e32836221b3
   Ma YN, 2015, ENVIRON INT, V84, P7, DOI 10.1016/j.envint.2015.07.006
   Mapanga RF, 2016, AM J PHYSIOL-HEART C, V310, pH153, DOI 10.1152/ajpheart.00206.2015
   Marikovsky M, 2003, J IMMUNOL, V170, P2993, DOI 10.4049/jimmunol.170.6.2993
   Mulligan C, 2017, ENVIRON TOXICOL, V32, P1399, DOI 10.1002/tox.22334
   Mustieles V, 2017, ENVIRON INT, V104, P48, DOI 10.1016/j.envint.2017.04.002
   Nowotny K, 2015, BIOMOLECULES, V5, P194, DOI 10.3390/biom5010194
   Pestana D., 2016, OPEN BIOTECHNOLOGY J, V10, P108, DOI [10.2174/1874070701610010108, DOI 10.2174/1874070701610010108]
   Piras S, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/9348651
   Rai V, 2012, J BIOL CHEM, V287, P5133, DOI 10.1074/jbc.M111.277731
   Ramasamy R, 2005, GLYCOBIOLOGY, V15, p16R, DOI 10.1093/glycob/cwi053
   Ramasamy R, 2011, ANN NY ACAD SCI, V1243, P88, DOI 10.1111/j.1749-6632.2011.06320.x
   Ranganathan AC, 2001, J BIOL CHEM, V276, P14264, DOI 10.1074/jbc.M100199200
   Rantakokko P, 2015, ENVIRON HEALTH-GLOB, V14, DOI 10.1186/s12940-015-0066-z
   Reddy GK, 1996, CLIN BIOCHEM, V29, P225, DOI 10.1016/0009-9120(96)00003-6
   Ritter L., 1995, A Review of Selected Persistent Organic Pollutants, P1
   Rosenbaum PF, 2017, ENVIRON INT, V108, P11, DOI 10.1016/j.envint.2017.07.017
   Ruzzin J, 2010, ENVIRON HEALTH PERSP, V118, P465, DOI 10.1289/ehp.0901321
   Sahai A, 2004, AM J PHYSIOL-GASTR L, V287, pG1035, DOI 10.1152/ajpgi.00199.2004
   Saxena NK, 2002, HEPATOLOGY, V35, P762, DOI 10.1053/jhep.2002.32029
   Singh VP, 2014, KOREAN J PHYSIOL PHA, V18, P1, DOI 10.4196/kjpp.2014.18.1.1
   STEGEMAN.H, 1967, CLIN CHIM ACTA, V18, P267, DOI 10.1016/0009-8981(67)90167-2
   Stewart JA, 2003, J MOL CELL CARDIOL, V35, P311, DOI 10.1016/S0022-2828(03)00013-0
   Tan ALY, 2010, AM J PHYSIOL-RENAL, V298, pF763, DOI 10.1152/ajprenal.00591.2009
   US Department of Health and Human Services Centers for Disease Control and Prevention, 2017, 4 NAT REP HUM EXP EN
   Wu M, 1996, EMBO J, V15, P4682, DOI 10.1002/j.1460-2075.1996.tb00845.x
   YAN SD, 1994, J BIOL CHEM, V269, P9889
   Zhang HJ, 2002, J BIOL CHEM, V277, P20919, DOI 10.1074/jbc.M109801200
NR 49
TC 7
Z9 7
U1 2
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-4081
EI 1522-7278
J9 ENVIRON TOXICOL
JI Environ. Toxicol.
PD OCT
PY 2019
VL 34
IS 10
BP 1149
EP 1159
DI 10.1002/tox.22817
EA JUL 2019
PG 11
WC Environmental Sciences; Toxicology; Water Resources
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology; Water Resources
GA JU6XI
UT WOS:000476063100001
PM 31313498
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Hu, RA
   Geng, YL
   Huang, YJ
   Liu, Z
   Li, F
   Dong, HX
   Ma, WW
   Song, KK
   Zhang, MM
   Zhang, Z
   Song, YF
AF Hu, Runan
   Geng, Yuli
   Huang, Yanjing
   Liu, Zhuo
   Li, Fan
   Dong, Haoxu
   Ma, Wenwen
   Song, Kunkun
   Zhang, Mingmin
   Zhang, Zhuo
   Song, Yufan
TI New insights into the interaction between polycystic ovary syndrome and
   psychiatric disorders: A narrative review
SO INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
LA English
DT Review
DE gut dysbiosis; hormonal disturbances; insulin resistance; interaction;
   obesity; polycystic ovary syndrome; psychiatric disorders
ID QUALITY-OF-LIFE; POPULATION-BASED COHORT; INSULIN-RESISTANCE;
   MENTAL-HEALTH; BIPOLAR DISORDER; CONTROLLED-TRIAL; INCREASED RISK;
   DEPRESSIVE-DISORDERS; PSYCHOLOGICAL BURDEN; METABOLIC SYNDROME
AB Polycystic ovary syndrome (PCOS) is a prevalent endocrine disease characterized by hyperandrogenism, ovulatory dysfunction, and ovarian polycystic changes, which combines with reproductive problems, metabolic disorders, and psychological disorders to exhibit a far-reaching impact on the physical and mental health of women. We reviewed previous research and discovered that psychiatric disorders are more common in PCOS patients and their children, potentially exacerbating the condition and creating a vicious loop. To understand the reasons, relevant articles were collected following the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines from PubMed, Web of Science, and Cochrane Library, through December 2022. Evidence suggested that PCOS-related clinical manifestations, hyperandrogenism, insulin resistance, obesity, gut dysbiosis, and other variables may increase the risk of psychiatric disorders in patients. In turn, psychiatric disorders may aggravate the pathologic process of PCOS and increase the difficulty of the treatment. We systematically reported the mechanisms underlying the psychiatric disorders-PCOS interactions, intending to provide potential ways to break the vicious cycle and lay the groundwork for future research. However, research on PCOS and psychiatric disorders were still in initial stages, which limited the scope of this review. More studies are needed to further verify our findings.
C1 [Hu, Runan; Geng, Yuli; Huang, Yanjing; Liu, Zhuo; Li, Fan; Song, Yufan] Huazhong Univ Sci & Technol, Tongji Hosp, Inst Integrated Tradit Chinese & Western Med, Tongji Med Coll, Wuhan, Peoples R China.
   [Dong, Haoxu; Ma, Wenwen; Song, Kunkun; Zhang, Mingmin; Song, Yufan] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Integrated Tradit Chinese & Western Med, Wuhan, Peoples R China.
   [Zhang, Zhuo] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Neurosurg, Wuhan, Peoples R China.
   [Song, Yufan] Huazhong Univ Sci & Technol, Tongji Hosp, Inst Integrated Tradit Chinese & Western Med, Tongji Med Coll, 13 Jiefang Ave, Wuhan 430030, Peoples R China.
   [Zhang, Zhuo] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Neurosurg, Wuhan 430030, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology;
   Huazhong University of Science & Technology; Huazhong University of
   Science & Technology
RP Song, YF (corresponding author), Huazhong Univ Sci & Technol, Tongji Hosp, Inst Integrated Tradit Chinese & Western Med, Tongji Med Coll, 13 Jiefang Ave, Wuhan 430030, Peoples R China.; Zhang, Z (corresponding author), Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Neurosurg, Wuhan 430030, Peoples R China.
EM zhzmclaren@gmail.com; songyufan23@163.com
RI Zhang, Mingmin/HTS-1310-2023
CR Açmaz G, 2013, SCI WORLD J, DOI 10.1155/2013/851815
   Agarwal SM, 2020, NEUROPHARMACOLOGY, V168, DOI 10.1016/j.neuropharm.2019.05.032
   Ahmadi M, 2020, AFR HEALTH SCI, V20, P1241, DOI 10.4314/ahs.v20i3.28
   Ahmed EI, 2008, NAT NEUROSCI, V11, P995, DOI 10.1038/nn.2178
   Alur-Gupta S, 2019, FERTIL STERIL, V112, P930, DOI 10.1016/j.fertnstert.2019.06.018
   Amorim D, 2018, COMPLEMENT THER CLIN, V31, P31, DOI 10.1016/j.ctcp.2018.01.008
   Annagür BB, 2013, J PSYCHOSOM RES, V74, P244, DOI 10.1016/j.jpsychores.2013.01.002
   Arnold SE, 2018, NAT REV NEUROL, V14, P168, DOI 10.1038/nrneurol.2017.185
   Asdaq SMB, 2020, J AFFECT DISORDERS, V274, P205, DOI 10.1016/j.jad.2020.05.086
   Asik M, 2015, J AFFECT DISORDERS, V185, P214, DOI 10.1016/j.jad.2015.06.043
   Auyeung B, 2010, MOL AUTISM, V1, DOI 10.1186/2040-2392-1-11
   Bahadori F, 2022, BMC WOMENS HEALTH, V22, DOI 10.1186/s12905-022-01983-9
   Banting LK, 2014, BMC WOMENS HEALTH, V14, DOI 10.1186/1472-6874-14-51
   Barnard L, 2007, HUM REPROD, V22, P2279, DOI 10.1093/humrep/dem108
   Baron-Cohen S, 2005, SCIENCE, V310, P819, DOI 10.1126/science.1115455
   Barry JA, 2011, HUM REPROD, V26, P2442, DOI 10.1093/humrep/der197
   Barry JA, 2011, J PSYCHOSOM OBST GYN, V32, P104, DOI 10.3109/0167482X.2011.568129
   Basirat Z, 2020, ARCH GYNECOL OBSTET, V301, P619, DOI 10.1007/s00404-019-05391-7
   Bazarganipour F, 2014, J SEX MED, V11, P1023, DOI 10.1111/jsm.12405
   Beccuti G, 2011, CURR OPIN CLIN NUTR, V14, P402, DOI 10.1097/MCO.0b013e3283479109
   Benrick A, 2017, P NATL ACAD SCI USA, V114, pE7187, DOI 10.1073/pnas.1708854114
   Benson S, 2009, HUM REPROD, V24, P1446, DOI 10.1093/humrep/dep031
   Berni TR, 2018, J CLIN ENDOCR METAB, V103, P2116, DOI 10.1210/jc.2017-02667
   Bhattacharya SM, 2010, FERTIL STERIL, V94, P357, DOI 10.1016/j.fertnstert.2009.09.025
   Blázquez E, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00161
   Bolognini D, 2016, MOL PHARMACOL, V89, P388, DOI 10.1124/mol.115.102301
   Bortolasci CC, 2015, J AFFECT DISORDERS, V179, P148, DOI 10.1016/j.jad.2015.03.041
   Braniste V, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3009759
   Brietzke E, 2018, NEUROSCI BIOBEHAV R, V94, P11, DOI 10.1016/j.neubiorev.2018.07.020
   Brutocao C, 2018, ENDOCRINE, V62, P318, DOI 10.1007/s12020-018-1692-3
   Calkin C, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.636174
   Cao J, 2021, ANESTH ANALG, V132, pE6, DOI 10.1213/ANE.0000000000003989
   Carta F, 2019, SCIENCE, V363, P248, DOI 10.1126/science.aav0581
   Carter CS, 2020, PHARMACOL REV, V72, P829, DOI 10.1124/pr.120.019398
   Cesta CE, 2020, PSYCHOL MED, V50, P616, DOI 10.1017/S0033291719000424
   Cesta CE, 2017, PSYCHONEUROENDOCRINO, V85, P63, DOI 10.1016/j.psyneuen.2017.08.007
   Cesta CE, 2016, PSYCHONEUROENDOCRINO, V73, P196, DOI 10.1016/j.psyneuen.2016.08.005
   Chabrolle C, 2007, REPRODUCTION, V133, P719, DOI 10.1530/REP-06-0244
   Chahwan B, 2019, J AFFECT DISORDERS, V253, P317, DOI 10.1016/j.jad.2019.04.097
   Che X, 2021, ANN NUTR METAB, V77, P313, DOI 10.1159/000519302
   Chen S, 2013, PSYCHIAT RES, V210, P825, DOI 10.1016/j.psychres.2013.08.056
   Chen XX, 2020, HUM REPROD, V35, P2336, DOI 10.1093/humrep/deaa192
   Cheng LX, 2016, ENDOCRINOLOGY, V157, P4875, DOI 10.1210/en.2015-2080
   Cherskov A, 2018, TRANSL PSYCHIAT, V8, DOI 10.1038/s41398-018-0186-7
   Chu C, 2019, NATURE, V574, P543, DOI 10.1038/s41586-019-1644-y
   Chudzik A, 2021, BIOMOLECULES, V11, DOI 10.3390/biom11071000
   Cincione RI, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph182312490
   Cipkala-Gaffin J, 2012, J WOMENS HEALTH, V21, P179, DOI 10.1089/jwh.2010.2541
   Clayton WJ, 2005, BRIT J DERMATOL, V152, P986, DOI 10.1111/j.1365-2133.2005.06426.x
   Clemente JC, 2018, BMJ-BRIT MED J, V360, DOI 10.1136/bmj.j5145
   Coban O G., 2019, J Pediatr Adolesc Gynecol, V32, P600
   Colle R, 2017, NEUROPSYCH DIS TREAT, V13, P9, DOI 10.2147/NDT.S121149
   Cooney LG, 2019, FERTIL STERIL, V111, P54, DOI 10.1016/j.fertnstert.2018.10.034
   Cooney LG, 2017, CURR PSYCHIAT REP, V19, DOI 10.1007/s11920-017-0834-2
   Cooney LG, 2017, HUM REPROD, V32, P1075, DOI 10.1093/humrep/dex044
   Cuperfain AB, 2020, NEUROSCI BIOBEHAV R, V111, P125, DOI 10.1016/j.neubiorev.2020.01.022
   Dai WY, 2022, PROG NEURO-PSYCHOPH, V115, DOI 10.1016/j.pnpbp.2021.110498
   Dalgaard CM, 2021, ACTA OBSTET GYN SCAN, V100, P2053, DOI 10.1111/aogs.14259
   Dapprich AL, 2021, PSYCHONEUROENDOCRINO, V128, DOI 10.1016/j.psyneuen.2021.105207
   Davari-Tanha Fatemeh, 2014, Acta Med Iran, V52, P46
   De Luca V, 2007, EUR PSYCHIAT, V22, P282, DOI 10.1016/j.eurpsy.2006.12.001
   Deeks AA, 2011, HUM REPROD, V26, P1399, DOI 10.1093/humrep/der071
   Deeks AA, 2010, FERTIL STERIL, V93, P2421, DOI 10.1016/j.fertnstert.2009.09.018
   Dinel AL, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024325
   Dokras A, 2018, FERTIL STERIL, V109, P888, DOI 10.1016/j.fertnstert.2018.01.038
   Dokras A, 2012, FERTIL STERIL, V97, P225, DOI 10.1016/j.fertnstert.2011.10.022
   Dominianni C, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0124599
   Dong HX, 2021, CHIN J INTEGR MED, V27, P737, DOI 10.1007/s11655-021-3482-z
   Dooley N, 2022, PSYCHONEUROENDOCRINO, V136, DOI 10.1016/j.psyneuen.2021.105623
   Drosdzol A, 2010, J PSYCHOSOM OBST GYN, V31, P168, DOI 10.3109/0167482X.2010.501398
   Dubey P, 2021, TRANSL PSYCHIAT, V11, DOI 10.1038/s41398-021-01699-8
   Dubey P, 2021, EUR J OBSTET GYN R B, V260, P189, DOI 10.1016/j.ejogrb.2021.03.033
   El Ansari W, 2014, CENT EUR J PUBL HEAL, V22, P90, DOI 10.21101/cejph.a3941
   Elsenbruch S, 2003, J CLIN ENDOCR METAB, V88, P5801, DOI 10.1210/jc.2003-030562
   Erny D, 2015, NAT NEUROSCI, V18, P965, DOI 10.1038/nn.4030
   Fan XD, 2006, SCHIZOPHR RES, V86, P30, DOI 10.1016/j.schres.2006.04.010
   Fauser BCJM, 2004, HUM REPROD, V19, P41, DOI 10.1093/humrep/deh098
   Firestein MR, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.1000732
   Fujita T, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-03542-x
   Gaspar JM, 2016, ACS CHEM NEUROSCI, V7, P131, DOI 10.1021/acschemneuro.5b00240
   Giampaolino P, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22042048
   Gökcen BB, 2020, GYNECOL ENDOCRINOL, V36, P764, DOI 10.1080/09513590.2020.1744554
   Greenwood EA, 2020, FERTIL STERIL, V113, P1039, DOI 10.1016/j.fertnstert.2020.01.016
   Greenwood EA, 2019, J CLIN ENDOCR METAB, V104, P2809, DOI 10.1210/jc.2019-00234
   Greenwood EA, 2019, FERTIL STERIL, V111, P147, DOI 10.1016/j.fertnstert.2018.10.004
   Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
   Han QX, 2021, MICROBIOME, V9, DOI 10.1186/s40168-021-01046-5
   Harnod T, 2020, J AFFECT DISORDERS, V273, P532, DOI 10.1016/j.jad.2020.04.032
   Harnod T, 2019, HUM REPROD, V34, P1830, DOI 10.1093/humrep/dez081
   Haroon E, 2009, PSYCHIAT RES-NEUROIM, V171, P10, DOI 10.1016/j.pscychresns.2008.03.006
   Harrison NA, 2021, PSYCHOPHYSIOLOGY, V58, DOI 10.1111/psyp.13694
   Hasan M, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0270102
   Hergüner S, 2015, INT J PSYCHIAT MED, V50, P317, DOI 10.1177/0091217415610311
   Hermans EJ, 2008, BIOL PSYCHIAT, V63, P263, DOI 10.1016/j.biopsych.2007.05.013
   Heshmati J, 2019, PROBIOTICS ANTIMICRO, V11, P1236, DOI 10.1007/s12602-018-9493-9
   Hollander E, 2003, NEUROPSYCHOPHARMACOL, V28, P193, DOI 10.1038/sj.npp.1300021
   Hollinrake E, 2007, FERTIL STERIL, V87, P1369, DOI 10.1016/j.fertnstert.2006.11.039
   Hu SH, 2019, ADV SCI, V6, DOI 10.1002/advs.201900752
   Huang YC, 2018, NEUROPSYCH DIS TREAT, V14, P3329, DOI 10.2147/NDT.S188340
   Hung JH, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0097041
   Insenser M, 2018, J CLIN ENDOCR METAB, V103, P2552, DOI 10.1210/jc.2017-02799
   Jahromi BN, 2018, TAIWAN J OBSTET GYNE, V57, P555, DOI 10.1016/j.tjog.2018.06.015
   Jedel E, 2010, HUM REPROD, V25, P450, DOI 10.1093/humrep/dep384
   Jiang LJ, 2022, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.789395
   Joëls M, 2009, NAT REV NEUROSCI, V10, P459, DOI 10.1038/nrn2632
   Jones GL, 2008, HUM REPROD UPDATE, V14, P15
   Kaldewaij R, 2017, CURR TOP BEHAV NEURO, V30, P275, DOI 10.1007/7854_2016_446
   Kandola A, 2019, NEUROSCI BIOBEHAV R, V107, P525, DOI 10.1016/j.neubiorev.2019.09.040
   Karjula S, 2022, ARCH WOMEN MENT HLTH, V25, P301, DOI 10.1007/s00737-021-01195-4
   Kashani L, 2013, PSYCHONEUROENDOCRINO, V38, P767, DOI 10.1016/j.psyneuen.2012.08.010
   Kayama H, 2020, ANNU REV IMMUNOL, V38, P23, DOI 10.1146/annurev-immunol-070119-115104
   Kerchner A, 2009, FERTIL STERIL, V91, P207, DOI 10.1016/j.fertnstert.2007.11.022
   Khan A, 2022, CURR PHARM BIOTECHNO, V23, P1041, DOI 10.2174/1389201022666210122125131
   Kim E, 2022, IMMUNITY, V55, P145, DOI 10.1016/j.immuni.2021.11.005
   Klipstein KG, 2006, J AFFECT DISORDERS, V91, P205, DOI 10.1016/j.jad.2006.01.011
   Kocak DY, 2022, PERSPECT PSYCHIATR C, V58, P2837, DOI 10.1111/ppc.13131
   Kogure GS, 2019, J AFFECT DISORDERS, V253, P385, DOI 10.1016/j.jad.2019.05.006
   Köhler O, 2016, CURR NEUROPHARMACOL, V14, P732, DOI 10.2174/1570159X14666151208113700
   Komarowska H, 2013, NEUROENDOCRINOL LETT, V34, P669
   Kosidou K, 2016, MOL PSYCHIATR, V21, P1441, DOI 10.1038/mp.2015.183
   Kosidou K, 2017, BIOL PSYCHIAT, V82, P651, DOI 10.1016/j.biopsych.2016.09.022
   Lee IO, 2021, J OBSTET GYNAECOL, V41, P1157, DOI 10.1080/01443615.2020.1849071
   Lee I, 2017, FERTIL STERIL, V107, P796, DOI 10.1016/j.fertnstert.2016.12.014
   Lenroot RK, 2006, NEUROSCI BIOBEHAV R, V30, P718, DOI 10.1016/j.neubiorev.2006.06.001
   Li MX, 2020, COMPLEMENT THER MED, V50, DOI 10.1016/j.ctim.2019.102202
   Light RS, 2021, WOMEN HEALTH ISS, V31, P177, DOI 10.1016/j.whi.2020.11.003
   Lim CED, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007689.pub4
   Liu R, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00324
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Silva NDLE, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00057
   Macut D, 2017, DIABETES RES CLIN PR, V130, P163, DOI 10.1016/j.diabres.2017.06.011
   Månsson M, 2008, PSYCHONEUROENDOCRINO, V33, P1132, DOI 10.1016/j.psyneuen.2008.06.003
   Manu P, 2015, ACTA PSYCHIAT SCAND, V132, P97, DOI 10.1111/acps.12445
   Margolis KG, 2021, GASTROENTEROLOGY, V160, P1486, DOI 10.1053/j.gastro.2020.10.066
   Martins LB, 2017, VITAM HORM, V104, P459, DOI 10.1016/bs.vh.2016.10.003
   Martins LB, 2019, NUTRITION, V66, P16, DOI 10.1016/j.nut.2019.03.017
   Miller AH, 2013, DEPRESS ANXIETY, V30, P297, DOI 10.1002/da.22084
   Misiak B, 2019, PSYCHONEUROENDOCRINO, V104, P74, DOI 10.1016/j.psyneuen.2019.02.019
   Mo L, 2019, CLIN ENDOCRINOL, V90, P570, DOI 10.1111/cen.13922
   Moran LJ, 2015, HUM REPROD, V30, P466, DOI 10.1093/humrep/deu318
   Moran LJ, 2012, HUM REPROD, V27, P2082, DOI 10.1093/humrep/des114
   Morelli NR, 2021, J AFFECT DISORDERS, V294, P410, DOI 10.1016/j.jad.2021.07.057
   Moy GA, 2013, PHYSIOL BEHAV, V109, P69, DOI 10.1016/j.physbeh.2012.11.008
   Neuhaus ZF, 2020, ARCH GYNECOL OBSTET, V301, P143, DOI 10.1007/s00404-020-05432-6
   Nguyen TTL, 2018, NEUROSCI BIOBEHAV R, V92, P7, DOI 10.1016/j.neubiorev.2018.05.014
   O'Mahony SM, 2015, BEHAV BRAIN RES, V277, P32, DOI 10.1016/j.bbr.2014.07.027
   Okanovic Milana, 2016, Med Pregl, V69, P121
   Page MJ, 2021, BMJ-BRIT MED J, V372, DOI [10.1136/bmj.n71, 10.1136/bmj.n160]
   Paoli A, 2020, J TRANSL MED, V18, DOI 10.1186/s12967-020-02277-0
   Pasch L, 2016, JAMA DERMATOL, V152, P783, DOI 10.1001/jamadermatol.2016.0358
   Pastore LM, 2011, J PSYCHOSOM RES, V71, P270, DOI 10.1016/j.jpsychores.2011.02.005
   Pereira ACP, 2011, AM J MED GENET B, V156B, P177, DOI 10.1002/ajmg.b.31153
   PHOENIX CH, 1959, ENDOCRINOLOGY, V65, P369, DOI 10.1210/endo-65-3-369
   Platzer M, 2019, WORLD J BIOL PSYCHIA, V20, P813, DOI 10.1080/15622975.2018.1500033
   Qaseem A, 2016, ANN INTERN MED, V164, P350, DOI 10.7326/M15-2570
   Qi XY, 2019, NAT MED, V25, P1225, DOI 10.1038/s41591-019-0509-0
   Radke S, 2015, SCI ADV, V1, DOI 10.1126/sciadv.1400074
   Rajska A, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21144853
   Rassi A, 2010, COMPR PSYCHIAT, V51, P599, DOI 10.1016/j.comppsych.2010.02.009
   Reagan LP, 2008, EUR J PHARMACOL, V585, P64, DOI 10.1016/j.ejphar.2008.02.050
   Ridaura V, 2015, CELL, V161, P193, DOI 10.1016/j.cell.2015.03.033
   Robinson SL, 2020, FERTIL STERIL, V113, P435, DOI 10.1016/j.fertnstert.2019.09.034
   Rodriguez-Paris D, 2019, PSYCHIATR POL, V53, P955, DOI 10.12740/PP/OnlineFirst/93105
   Rowland T, 2018, BRIT J PSYCHIAT, V213, P514, DOI 10.1192/bjp.2018.144
   Rudzki L, 2019, PSYCHONEUROENDOCRINO, V100, P213, DOI 10.1016/j.psyneuen.2018.10.010
   Sandrini L, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19082281
   Schulz KM, 2006, HORM BEHAV, V50, P477, DOI 10.1016/j.yhbeh.2006.06.006
   Sen ZD, 2021, BRAIN BEHAV IMMUN, V93, P335, DOI 10.1016/j.bbi.2020.12.020
   Shamasbi SG, 2020, EUR J NUTR, V59, P433, DOI 10.1007/s00394-019-02033-1
   Shi XB, 2011, ARCH GYNECOL OBSTET, V284, P773, DOI 10.1007/s00404-011-1947-1
   Singh MK, 2019, HORM BEHAV, V108, P73, DOI 10.1016/j.yhbeh.2018.03.009
   Steegers-Theunissen RPM, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21218211
   Stefanaki C, 2015, STRESS, V18, P57, DOI 10.3109/10253890.2014.974030
   Stouffer MA, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms9543
   Strandwitz P, 2018, BRAIN RES, V1693, P128, DOI 10.1016/j.brainres.2018.03.015
   Sukhapure M, 2022, ARCH WOMEN MENT HLTH, V25, P87, DOI 10.1007/s00737-021-01158-9
   Sulaiman MAH, 2017, INT J WOMENS HEALTH, V9, P897, DOI 10.2147/IJWH.S145383
   Tan J, 2017, CHINESE MED J-PEKING, V130, P262, DOI 10.4103/0366-6999.198916
   Tan S, 2008, HUM REPROD, V23, P2064, DOI 10.1093/humrep/den227
   Tang R, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00298
   Tay CT, 2019, FERTIL STERIL, V112, P353, DOI 10.1016/j.fertnstert.2019.03.027
   Teede HJ, 2018, HUM REPROD, V33, P1602, DOI 10.1093/humrep/dey256
   Teede HJ, 2018, FERTIL STERIL, V110, P364, DOI 10.1016/j.fertnstert.2018.05.004
   Teede HJ, 2011, MED J AUSTRALIA, V195, pS69, DOI 10.5694/mja11.10915
   Terburg D, 2012, PSYCHOL SCI, V23, P459, DOI 10.1177/0956797611433336
   Terburg D, 2009, INT J LAW PSYCHIAT, V32, P216, DOI 10.1016/j.ijlp.2009.04.008
   Thannickal A, 2020, CLIN ENDOCRINOL, V92, P338, DOI 10.1111/cen.14153
   Tian PJ, 2020, NEUROBIOL STRESS, V12, DOI 10.1016/j.ynstr.2020.100216
   Ventura T, 2014, NUTRITION, V30, P252, DOI 10.1016/j.nut.2013.06.010
   Volman I, 2016, ENEURO, V3, DOI 10.1523/ENEURO.0107-15.2016
   Volman I, 2011, CURR BIOL, V21, P1766, DOI 10.1016/j.cub.2011.08.050
   Vuong E, 2020, J AFFECT DISORDERS, V260, P372, DOI 10.1016/j.jad.2019.09.050
   Wallace CJK, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.618279
   Walters KA, 2018, TRENDS ENDOCRIN MET, V29, P842, DOI 10.1016/j.tem.2018.08.005
   Watson K, 2018, NEUROPHARMACOLOGY, V136, P327, DOI 10.1016/j.neuropharm.2017.11.038
   Weiner CL, 2004, PSYCHOSOM MED, V66, P356, DOI 10.1097/01.psy.0000127871.46309.fe
   Wild RA, 2010, J CLIN ENDOCR METAB, V95, P2038, DOI 10.1210/jc.2009-2724
   Wilmes L, 2021, NEUROGASTROENT MOTIL, V33, DOI 10.1111/nmo.14095
   Woodward A, 2020, ADV EXP MED BIOL, V1228, P123, DOI 10.1007/978-981-15-1792-1_8
   Yang G, 2021, METABOLISM, V117, DOI 10.1016/j.metabol.2021.154712
   Yang Y, 2021, J AFFECT DISORDERS, V282, P51, DOI 10.1016/j.jad.2020.12.084
   Yin X, 2017, SLEEP MED, V37, P193, DOI 10.1016/j.sleep.2017.02.012
   Zhang MM, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.933110
   Zhang YL, 2021, PHARMACOL RES, V164, DOI 10.1016/j.phrs.2020.105376
   Zheng RQ, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/5555028
NR 205
TC 5
Z9 6
U1 1
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0020-7292
EI 1879-3479
J9 INT J GYNECOL OBSTET
JI Int. J. Gynecol. Obstet.
PD FEB
PY 2024
VL 164
IS 2
BP 387
EP 420
DI 10.1002/ijgo.14988
EA JUL 2023
PG 34
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA FA4T0
UT WOS:001026578500001
PM 37458179
OA Bronze
DA 2025-06-11
ER

PT J
AU Kondo, T
   Miyakawa, N
   Kitano, S
   Watanabe, T
   Goto, R
   Suico, MA
   Sato, M
   Takaki, Y
   Sakaguchi, M
   Igata, M
   Kawashima, J
   Motoshima, H
   Matsumura, T
   Kai, H
   Araki, E
AF Kondo, Tatsuya
   Miyakawa, Nobukazu
   Kitano, Sayaka
   Watanabe, Takuro
   Goto, Rieko
   Suico, Mary Ann
   Sato, Miki
   Takaki, Yuki
   Sakaguchi, Masaji
   Igata, Motoyuki
   Kawashima, Junji
   Motoshima, Hiroyuki
   Matsumura, Takeshi
   Kai, Hirofumi
   Araki, Eiichi
TI Activation of heat shock response improves biomarkers of NAFLD in
   patients with metabolic diseases
SO ENDOCRINE CONNECTIONS
LA English
DT Article
DE heat shock response (HSR); type 2 diabetes (T2DM); nonalcoholic fatty
   liver disease (NAFLD); endoplasmic reticulum (ER) stress
ID FATTY LIVER-DISEASE; ENDOPLASMIC-RETICULUM STRESS; MILD
   ELECTRICAL-STIMULATION; VISCERAL ADIPOSITY; HEPATIC STEATOSIS;
   INSULIN-RESISTANCE; INDEX; HSP72; EXPRESSION; PROTECTS
AB Nonalcoholic fatty liver disease (NAFLD) is often accompanied by metabolic disorders such as metabolic syndrome and type 2 diabetes (T2DM). Heat shock response (HSR) is one of the most important homeostatic abilities but is deteriorated by chronic metabolic insults. Heat shock (HS) with an appropriate mild electrical stimulation (MES) activates HSR and improves metabolic abnormalities including insulin resistance, hyperglycemia and inflammation in metabolic disorders. To analyze the effects of HS + MES treatment on NAFLD biomarkers, three cohorts including healthy men (two times/week, n = 10), patients with metabolic syndrome (four times/week, n = 40), and patients with T2DM (n = 100; four times/week (n = 40) and two, four, seven times/week (n = 20 each)) treated with HS + MES were retrospectively analyzed. The healthy subjects showed no significant alterations in NAFLD biomarkers after the treatment. In patients with metabolic syndrome, many of the NAFLD steatosis markers, including fatty liver index, NAFLD-liver fat score, liver/spleen ratio and hepatic steatosis index and NAFLD fibrosis marker, aspartate aminotransferase/ alanine aminotransferase (AST/ALT) ratio, were improved upon the treatment. In patients with T2DM, all investigated NAFLD steatosis markers were improved and NAFLD fibrosis markers such as the AST/ALT ratio, fibrosis-4 index and NAFLD-fibrosis score were improved upon the treatment. Thus, HS + MES, a physical intervention, may become a novel treatment strategy for NAFLD as well as metabolic disorders.
C1 [Kondo, Tatsuya; Kitano, Sayaka; Igata, Motoyuki] Kumamoto Univ Hosp, Dept Diabet Metab & Endocrinol, Chuo Ward, Kumamoto, Japan.
   [Miyakawa, Nobukazu; Watanabe, Takuro; Goto, Rieko; Sato, Miki; Takaki, Yuki; Sakaguchi, Masaji; Kawashima, Junji; Motoshima, Hiroyuki; Matsumura, Takeshi; Araki, Eiichi] Kumamoto Univ, Fac Life Sci, Dept Metab Med, Chuo Ward, Kumamoto, Japan.
   [Suico, Mary Ann; Kai, Hirofumi] Kumamoto Univ, Fac Life Sci, Dept Mol Med, Chuo Ward, Kumamoto, Japan.
C3 Kumamoto University; Kumamoto University; Kumamoto University
RP Kondo, T (corresponding author), Kumamoto Univ Hosp, Dept Diabet Metab & Endocrinol, Chuo Ward, Kumamoto, Japan.
EM t-kondo@gpo.kumamoto-u.ac.jp
RI Matsumura, Takeshi/B-3734-2011
OI Goto, Rieko/0000-0001-5370-4421
FU Japanese Government (MEdical Device InCubation (MEDIC) platform from the
   Ministry of Economy, Trade and Industry Japan) [24-065]; Grants-in-Aid
   for Scientific Research [21K08533, 20K07086] Funding Source: KAKEN
FX This study was supported by the Japanese Government (MEdical Device
   InCubation (MEDIC) platform from the Ministry of Economy, Trade and
   Industry Japan; Grant No. 24-065). The sponsor of this study had no role
   in the study design, data collection, data analysis, data
   interpretation, or writing of the report.
CR Adachi H, 2010, AM J PHYSIOL-ENDOC M, V299, pE764, DOI 10.1152/ajpendo.00075.2010
   Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
   Angulo P, 2007, HEPATOLOGY, V45, P846, DOI 10.1002/hep.21496
   Anstee QM, 2019, NAT REV GASTRO HEPAT, V16, P411, DOI 10.1038/s41575-019-0145-7
   Archer AE, 2018, AM J PHYSIOL-REG I, V315, pR696, DOI 10.1152/ajpregu.00073.2018
   Bedi O, 2019, J CLIN EXP HEPATOL, V9, P607, DOI 10.1016/j.jceh.2018.10.004
   Bedogni G, 2006, BMC GASTROENTEROL, V6, DOI 10.1186/1471-230X-6-33
   Borroni G, 2006, ALIMENT PHARM THER, V24, P797, DOI 10.1111/j.1365-2036.2006.03034.x
   Botros Mona, 2013, Clin Biochem Rev, V34, P117
   Chan JYH, 2004, CIRCULATION, V110, P3560, DOI 10.1161/01.CIR.0000143082.63063.33
   Chen HW, 2005, SHOCK, V24, P232, DOI 10.1097/01.shk.0000174020.87439.f2
   Chung J, 2008, P NATL ACAD SCI USA, V105, P1739, DOI 10.1073/pnas.0705799105
   DERITIS F, 1957, CLIN CHIM ACTA, V2, P70, DOI 10.1016/0009-8981(57)90027-X
   Di Naso F, 2015, OBESITY, V23, P120, DOI 10.1002/oby.20919
   Fedchuk L, 2014, ALIMENT PHARM THER, V40, P1209, DOI 10.1111/apt.12963
   Gonçalves NB, 2018, CLINICS, V73, DOI 10.6061/clinics/2018/e150
   Guerrero-Romero F, 2010, J CLIN ENDOCR METAB, V95, P3347, DOI 10.1210/jc.2010-0288
   Gupta S, 2010, PLOS BIOL, V8, DOI 10.1371/journal.pbio.1000410
   Haneda M, 2018, J DIABETES INVEST, V9, P657, DOI 10.1111/jdi.12810
   Hotamisligil GS, 2005, DIABETES, V54, pS73, DOI 10.2337/diabetes.54.suppl_2.S73
   Kadowaki S, 2019, J ENDOCR SOC, V3, P1409, DOI 10.1210/js.2019-00052
   Kitano S, 2019, AM J PHYSIOL-ENDOC M, V316, pE305, DOI 10.1152/ajpendo.00215.2018
   Kondo T, 2016, SCI REP-UK, V6, DOI 10.1038/srep35690
   Kondo T, 2014, EBIOMEDICINE, V1, P80, DOI 10.1016/j.ebiom.2014.11.001
   Kondo T, 2010, OBES RES CLIN PRACT, V4, pE101, DOI 10.1016/j.orcp.2009.09.007
   Kotronen A, 2009, GASTROENTEROLOGY, V137, P865, DOI 10.1053/j.gastro.2009.06.005
   Kurucz I, 2002, DIABETES, V51, P1102, DOI 10.2337/diabetes.51.4.1102
   Lee JH, 2010, DIGEST LIVER DIS, V42, P503, DOI 10.1016/j.dld.2009.08.002
   Martins Ian James, 2018, Diseases, V6, DOI 10.3390/diseases6020039
   Matsuzawa Y, 2005, J ATHEROSCLER THROMB, V12, P301, DOI 10.5551/jat.12.301
   Morino S, 2008, J PHARMACOL SCI, V108, P222, DOI 10.1254/jphs.08180SC
   Morino S, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0004068
   Ohki T, 2009, GUT, V58, P839, DOI 10.1136/gut.2008.164053
   Parker BL, 2019, NATURE, V567, P187, DOI 10.1038/s41586-019-0984-y
   Petta S, 2010, HEPATOLOGY, V52, P1543, DOI 10.1002/hep.23859
   Putics A, 2008, ANTIOXID REDOX SIGN, V10, P65, DOI 10.1089/ars.2007.1866
   Röhrl C, 2014, J LIPID RES, V55, P94, DOI 10.1194/jlr.M043299
   Sharma AK, 2011, BRIT J NUTR, V106, P1713, DOI 10.1017/S000711451100225X
   Sterling RK, 2006, HEPATOLOGY, V43, P1317, DOI 10.1002/hep.21178
   Sumida Y, 2012, BMC GASTROENTEROL, V12, DOI 10.1186/1471-230X-12-2
   Tiss A, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-106
   Wong VWS, 2018, NAT REV GASTRO HEPAT, V15, P461, DOI 10.1038/s41575-018-0014-9
   Yamagami K, 1998, J SURG RES, V79, P47, DOI 10.1006/jsre.1998.5403
   Yoneda M, 2007, ALCOHOL CLIN EXP RES, V31, p15S, DOI 10.1111/j.1530-0277.2006.00281.x
   Zeng XY, 2015, BRIT J PHARMACOL, V172, P4303, DOI 10.1111/bph.13209
   Zhang JP, 2001, ACTA PHARMACOL SIN, V22, P183
   Zhou HP, 2014, FRONT GENET, V5, DOI 10.3389/fgene.2014.00112
NR 47
TC 4
Z9 4
U1 0
U2 0
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
EI 2049-3614
J9 ENDOCR CONNECT
JI Endocr. Connect.
PD MAY
PY 2021
VL 10
IS 5
BP 521
EP 533
DI 10.1530/EC-21-0084
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA SR5VW
UT WOS:000661111700008
PM 33883285
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Davis, CR
   Usher, N
   Dearing, E
   Barkai, AR
   Crowell-Doom, C
   Neupert, SD
   Mantzoros, CS
   Crowell, JA
AF Davis, Cynthia R.
   Usher, Nicole
   Dearing, Eric
   Barkai, Ayelet R.
   Crowell-Doom, Cynthia
   Neupert, Shevaun D.
   Mantzoros, Christos S.
   Crowell, Judith A.
TI Attachment and the Metabolic Syndrome in Midlife: The Role of
   Interview-Based Discourse Patterns
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE adult attachment; metabolic syndrome; adverse childhood experiences
ID ADVERSE CHILDHOOD EXPERIENCES; WORKING MODELS; SOCIAL RELATIONSHIPS;
   MEDICAL-TREATMENT; HEALTH BEHAVIOR; CHRONIC DISEASE; CENTRAL OBESITY;
   FOLLOW-UP; SELF-CARE; DEPRESSION
AB Objective Adult attachment discourse patterns and current family relationship quality were examined as correlates of health behaviors and number of metabolic syndrome (MetS) criteria met, and as mediators of the link between childhood adversity and these health outcomes.
   Methods A sample of 215 white/European American and black/African American adults aged 35 to 55 years were examined using a cross-sectional study design. Discourse was assessed with the Adult Attachment Interview, using coherence (a marker of attachment security), unresolved trauma/loss (a marker of disorganized cognitions related to trauma or loss), and idealization (minimizing stressful experiences and their impact) scores. Relationship quality, adverse childhood experiences, and current depressive symptoms were assessed, as were health behaviors of diet, exercise, and smoking. MetS includes obesity, elevated blood pressure, elevated fasting glucose, high triglycerides, and low high-density lipoprotein cholesterol.
   Results Using path analysis and including childhood adversity severity and depressive symptoms in the model, both Adult Attachment Interview coherence and unresolved trauma/loss were directly linked to the number of MetS criteria (r = 0.186 and r = 0.170, respectively). Idealization was indirectly linked to MetS through poor diet (r = 0.183). The final model explained 21% of the variance in scores for the number of MetS criteria met.
   Conclusions Insecure adult attachment is associated with increased risk of MetS.
C1 [Davis, Cynthia R.; Usher, Nicole; Crowell-Doom, Cynthia; Crowell, Judith A.] Judge Baker Childrens Ctr, Boston, MA USA.
   [Dearing, Eric] Boston Coll, Boston, MA USA.
   [Barkai, Ayelet R.] Cambridge Hlth Alliance, Dept Psychiat, Cambridge, MA USA.
   [Neupert, Shevaun D.] N Carolina State Univ, Dept Psychol, Raleigh, NC 27695 USA.
   [Mantzoros, Christos S.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Endocrinol, Boston, MA 02215 USA.
   [Mantzoros, Christos S.] Harvard Univ, Sch Med, Endocrinol Sect, Boston VA Healthcare Syst, Boston, MA USA.
   [Crowell, Judith A.] SUNY Stony Brook, Sch Med, Dept Psychiat, Stony Brook, NY 11794 USA.
C3 Harvard University; Harvard University Medical Affiliates; Judge Baker's
   Children's Center; Boston College; Harvard University; Harvard
   University Medical Affiliates; Cambridge Health Alliance; North Carolina
   State University; Harvard University; Harvard University Medical
   Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical
   School; Harvard University; Harvard Medical School; Harvard University
   Medical Affiliates; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Boston Healthcare System; State University of
   New York (SUNY) System; Stony Brook University
RP Crowell, JA (corresponding author), SUNY Stony Brook, Div Child & Adolescent Psychiat, Putnam Hall South Campus, Stony Brook, NY 11794 USA.
EM judith.crowell@stonybrookmedicine.edu
RI Mantzoros, Christos/Y-2902-2019
OI Neupert, Shevaun/0000-0001-5994-3060
FU National Institute of Aging [R01 AG 032030]; National Institute of
   Diabetes and Digestive and Kidney Diseases [81913]; Harvard Clinical and
   Translational Science Center from National Center for Research Resources
   [UL1 RR025758]
FX This research was supported by the National Institute of Aging (Grant
   No. R01 AG 032030, to J.A. Crowell), National Institute of Diabetes and
   Digestive and Kidney Diseases (Grant No. 81913, to C. S. Mantzoros), and
   Harvard Clinical and Translational Science Center (Grant No. UL1
   RR025758, to C. S. Mantzoros) from the National Center for Research
   Resources. The authors have no conflicts of interest to disclose.
CR Ackard DM, 2006, AM J PREV MED, V30, P59, DOI 10.1016/j.amepre.2005.09.013
   Ainsworth BE, 2011, MED SCI SPORT EXER, V43, P1575, DOI 10.1249/MSS.0b013e31821ece12
   Ainsworth M., 1978, Patterns of attachment: A psychological study of the strange situation
   Ainsworth M, 1991, ATTACHMENT LIFE CYCL, P33
   AINSWORTH MDS, 1985, B NEW YORK ACAD MED, V61, P792
   Anda RF, 1999, JAMA-J AM MED ASSOC, V282, P1652, DOI 10.1001/jama.282.17.1652
   Beck A, 1996, MANUAL BECK DEPRESSI, V82
   Bentley T, 2009, OBESITY, V17, P1900, DOI 10.1038/oby.2009.160
   BLOCK G, 1986, AM J EPIDEMIOL, V124, P453, DOI 10.1093/oxfordjournals.aje.a114416
   Bosch OG, 2012, WORLD J BIOL PSYCHIA, V13, P556, DOI 10.3109/15622975.2012.665477
   BOWLBY J, 1958, INT J PSYCHOANAL, V39, P350
   Bowlby J., 1969, ATTACHMENT LOSS 3, V1
   Bremner J Douglas, 2005, J Trauma Dissociation, V6, P51, DOI 10.1300/J229v06n02_06
   BRETHERTON I, 1985, MONOGR SOC RES CHILD, V50, P3, DOI 10.2307/3333824
   Bretherton I., 2008, Handbook of attachment: Theory, research, and clinical applications, P102
   Brown GW, 2007, J AFFECT DISORDERS, V103, P217, DOI 10.1016/j.jad.2007.06.003
   BROWNE MW, 1989, MULTIVAR BEHAV RES, V24, P445, DOI 10.1207/s15327906mbr2404_4
   Bulloch AG, 2009, DEPRESS ANXIETY, V26, P1172, DOI 10.1002/da.20618
   Caplan RA, 2014, INFLAMM BOWEL DIS, V20, P909, DOI 10.1097/MIB.0000000000000015
   Cassidy J, 2013, DEV PSYCHOPATHOL, V25, P1415, DOI 10.1017/S0954579413000692
   CDC, 2012, ADV CHILDH EXP STUD
   Census U, 2012, US CENS BUR STAT COU
   Ciechanowski P, 2004, PSYCHOSOM MED, V66, P720, DOI 10.1097/01.psy.0000138125.59122.23
   Ciechanowski P, 2003, PAIN, V104, P627, DOI 10.1016/S0304-3959(03)00120-9
   Coan JamesA., 2008, Handbook of Attachment: Theory, Research, and Clinical Applications, P241, DOI [10.1080/02643944.2018.1429117, DOI 10.1080/02643944.2018.1429117]
   Creasey G, 2002, J COUNS PSYCHOL, V49, P365, DOI 10.1037//0022-0167.49.3.365
   Crowell J, 2008, CLIN APPL ADULT ATTA, P223
   Crowell JA, 2002, DEV PSYCHOL, V38, P679, DOI 10.1037//0012-1649.38.5.679
   D'Argenio A, 2009, PHYSIOL BEHAV, V98, P543, DOI 10.1016/j.physbeh.2009.08.010
   Danese A, 2012, PHYSIOL BEHAV, V106, P29, DOI 10.1016/j.physbeh.2011.08.019
   Davis CR, 2014, METABOLISM, V63, P199, DOI 10.1016/j.metabol.2013.08.013
   DiMatteo MR, 2000, ARCH INTERN MED, V160, P2101, DOI 10.1001/archinte.160.14.2101
   DiMatteo MR, 2004, HEALTH PSYCHOL, V23, P207, DOI 10.1037/0278-6133.23.2.207
   DOZIER M, 1992, CHILD DEV, V63, P1473, DOI 10.1111/j.1467-8624.1992.tb01708.x
   Dykas MJ, 2006, ATTACH HUM DEV, V8, P221, DOI 10.1080/14616730600856099
   Eaker ED, 2007, PSYCHOSOM MED, V69, P509, DOI 10.1097/PSY.0b013e3180f62357
   FEENEY JA, 1994, HEALTH PSYCHOL, V13, P334, DOI 10.1037/0278-6133.13.4.334
   First M.B., 2016, Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version
   Fisher L, 2014, DIABETIC MED, V31, P764, DOI 10.1111/dme.12428
   Freed PJ, 2009, BIOL PSYCHIAT, V66, P33, DOI 10.1016/j.biopsych.2009.01.019
   Fricchione G., 2011, COMPASSION HEALING M
   Gable SL, 2013, EMOT REV, V5, P269, DOI 10.1177/1754073913477513
   Glanz Karen., 2008, Health Behavior and Health Education: Theory, Research and Practice, P211
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Hammen C, 2009, DEPRESS ANXIETY, V26, P718, DOI 10.1002/da.20571
   Harris PA, 2009, J BIOMED INFORM, V42, P377, DOI 10.1016/j.jbi.2008.08.010
   Hauser S.T., 1991, Adolescents and their families : paths of ego development
   HAUSER ST, 1984, CHILD DEV, V55, P195, DOI 10.2307/1129845
   Heene E, 2007, FAM PROCESS, V46, P499, DOI 10.1111/j.1545-5300.2007.00228.x
   Hesse E, 2009, HDB ATTACHMENT THEOR, P552
   Hostinar CE, 2014, PSYCHOL BULL, V140, P256, DOI 10.1037/a0032671
   HOUSE JS, 1988, SCIENCE, V241, P540, DOI 10.1037/0003-066X.59.8.676
   Jaremka LM, 2013, PSYCHOL SCI, V24, P272, DOI 10.1177/0956797612452571
   Joung KE, 2014, J CLIN ENDOCR METAB, V99, pE1055, DOI 10.1210/jc.2013-3669
   Kaufman J, 2004, P NATL ACAD SCI USA, V101, P17316, DOI 10.1073/pnas.0404376101
   Kenny D., 2012, MEASURING MODEL FIT
   KESSLER RC, 1993, PSYCHOL MED, V23, P679, DOI 10.1017/S0033291700025460
   Kidd T, 2005, BRIT J HEALTH PSYCH, V10, P531, DOI 10.1111/j.2044-8287.2005.tb00485.x
   Kiecolt-Glaser JK, 2001, PSYCHOL BULL, V127, P472, DOI 10.1037//0033-2909.127.4.472
   Krinsley KE, 1996, MEASUREMENT STRESS T
   Landers MS, 2012, DEV NEUROSCI-BASEL, V34, P101, DOI 10.1159/000336732
   Lin EHB, 2004, DIABETES CARE, V27, P2154, DOI 10.2337/diacare.27.9.2154
   MacCallum RC, 1996, PSYCHOL METHODS, V1, P130, DOI 10.1037/1082-989X.1.2.130
   Madigan S, 2007, J CHILD PSYCHOL PSYC, V48, P1042, DOI 10.1111/j.1469-7610.2007.01805.x
   Magai C, 2008, HDB ATTACHMENT THEOR
   Main M, 1985, MONOGRAPHS SOC RES C, V50, P66
   Marvin Robert, 2002, Attach Hum Dev, V4, P107, DOI 10.1080/14616730252982491
   Maunder RG, 2001, PSYCHOSOM MED, V63, P556, DOI 10.1097/00006842-200107000-00006
   Maunder RG, 2009, GEN HOSP PSYCHIAT, V31, P123, DOI 10.1016/j.genhosppsych.2008.10.007
   McCullough ML, 2006, PUBLIC HEALTH NUTR, V9, P152, DOI 10.1079/PHN2005938
   McCullough ML, 2002, AM J CLIN NUTR, V76, P1261, DOI 10.1093/ajcn/76.6.1261
   McEwen BS, 2013, METABOLISM, V62, pS20, DOI 10.1016/j.metabol.2012.08.020
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   McWilliams LA, 2010, HEALTH PSYCHOL, V29, P446, DOI 10.1037/a0020061
   Meyer D, 2011, FAM J, V19, P274, DOI 10.1177/1066480711406678
   Midei AJ, 2013, HEALTH PSYCHOL, V32, P121, DOI 10.1037/a0027891
   Miller GE, 2011, PSYCHOL BULL, V137, P959, DOI 10.1037/a0024768
   Najib A, 2004, AM J PSYCHIAT, V161, P2245, DOI 10.1176/appi.ajp.161.12.2245
   Owens G, 1995, MONOGR SOC RES CHILD, V60, P216, DOI 10.2307/1166180
   PAFFENBARGER RS, 1993, MED SCI SPORT EXER, V25, P60, DOI 10.1249/00005768-199301000-00010
   Pechtel P, 2011, PSYCHOPHARMACOLOGY, V214, P55, DOI 10.1007/s00213-010-2009-2
   Pervanidou P, 2012, METABOLISM, V61, P611, DOI 10.1016/j.metabol.2011.10.005
   Pouwer F, 2010, DISCOV MED, V9, P112
   Puig J, 2013, HEALTH PSYCHOL, V32, P409, DOI 10.1037/a0028889
   Raby KL, 2013, J CHILD PSYCHOL PSYC, V54, P1223, DOI 10.1111/jcpp.12093
   Repetti RL, 2002, PSYCHOL BULL, V128, P330, DOI 10.1037/0033-2909.128.2.330
   REY JM, 1988, AM J PSYCHIAT, V145, P286
   Scott KM, 2012, BRIT J PSYCHIAT, V200, P469, DOI 10.1192/bjp.bp.111.103267
   Simpson JA, 2002, PERS SOC PSYCHOL B, V28, P598, DOI 10.1177/0146167202288004
   Simpson K., 2011, Validity and reliability of the Paffenbarger Physical Activity Questionnaire among healthy adults
   Spencer SJ, 2011, STRESS, V14, P233, DOI 10.3109/10253890.2010.534831
   Srikanthan P, 2009, ANN EPIDEMIOL, V19, P724, DOI 10.1016/j.annepidem.2009.05.003
   SROUFE LA, 1977, MERRILL PALMER QUART, V23, P3
   Stovall-McClough KC, 2006, J CONSULT CLIN PSYCH, V74, P219, DOI 10.1037/0022-006X.74.2.219
   Sullivan RM, 2012, HASTINGS LAW J, V63, P1553
   Suvak MK, 2011, J TRAUMA STRESS, V24, P3, DOI 10.1002/jts.20618
   Thomas C, 2008, PEDIATRICS, V121, pE1240, DOI 10.1542/peds.2007-2403
   Treboux D, 2004, DEV PSYCHOL, V40, P295, DOI 10.1037/0012-1649.40.2.295
   Umberson D, 2010, ANNU REV SOCIOL, V36, P139, DOI 10.1146/annurev-soc-070308-120011
   US Department of Health and Human Services, 2012, PREV TOB US YOUTH YO
   Volkow ND, 2011, TRENDS COGN SCI, V15, P37, DOI 10.1016/j.tics.2010.11.001
   Vythilingam M, 2002, AM J PSYCHIAT, V159, P2072, DOI 10.1176/appi.ajp.159.12.2072
   Waters E, 2000, CHILD DEV, V71, P684, DOI 10.1111/1467-8624.00176
   Waters E, 1991, MINNESOTA S CHILD PS, V23
   Waters HS, 2006, ATTACH HUM DEV, V8, P185, DOI 10.1080/14616730600856016
   Waters TEA, 2013, ATTACH HUM DEV, V15, P316, DOI 10.1080/14616734.2013.782657
   Weiss R.S., 1982, PLACE ATTACHMENT HUM
   Weissman M.M., 1974, DEPRESSED WOMAN STUD
   WEISSMAN MM, 1976, AM J PSYCHIAT, V133, P757
   Welborn TA, 2007, EUR J CLIN NUTR, V61, P1373, DOI 10.1038/sj.ejcn.1602656
   Whisman MA, 2008, RISK FACTORS IN DEPRESSION, P363
   Wiersma JE, 2009, J CLIN PSYCHIAT, V70, P983, DOI 10.4088/JCP.08m04521
NR 112
TC 18
Z9 21
U1 0
U2 25
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD OCT
PY 2014
VL 76
IS 8
BP 611
EP 621
DI 10.1097/PSY.0000000000000107
PG 11
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA AR9HK
UT WOS:000343883900005
PM 25264975
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Mykolayivna, NI
   Adebusoye, FT
   Awuah, WA
   Anatoliivna, SA
   Volodymyrivna, BT
   Fedorivna, HS
   Abdul-Rahman, T
AF Mykolayivna, Nikitina I.
   Adebusoye, Favor T.
   Awuah, Wireko A.
   Anatoliivna, Sinkina A.
   Volodymyrivna, Babar T.
   Fedorivna, Herasymenko S.
   Abdul-Rahman, Toufik
TI Stress-induced menstrual disorders in adolescents during the Ukrainian
   war: cross-sectional study
SO ANNALS OF MEDICINE AND SURGERY
LA English
DT Article
DE menstrual disorder; psychoemotional disorder; reproductive function;
   stress; war
ID METABOLIC SYNDROME; HEALTH
AB Objective:The objective was to investigate the peculiarities of menstrual cycle changes in teenagers exposed to a devastating war for an extended period. Methods:A cross-sectional study of 120 Ukrainian girls aged 9-18 asked to complete a survey about their menstrual cycle status 3-6 months after the war began. Other examination methods used included anthropometry, laboratory, and instrumental studies. Results:The frequency of menstrual cycle disorders in the study group was 65.8% (n=79). The following menstrual cycle disorders were most frequently reported; dysmenorrhea 45.6% (n=36), excessive menstruation during puberty 27.8% (n=22), and secondary amenorrhea 26.6% (n=21). The 52.5% (n=63) of those examined had pathological menarche. The 81.7% (n=63) of respondents reported a change in eating habits in the previous few months. The 61.9% (n=39) of these children had dyshormonal disorders or met the criteria for metabolic syndrome. Conclusion:Adolescent females under stress warrant a quick assessment of their psychoemotional and metabolic conditions. The protection from future menstruation and reproductive illnesses depends on this tactic. By diagnosing these conditions promptly and well-managed, adolescent females may maintain good physical and emotional health.
C1 [Mykolayivna, Nikitina I.; Adebusoye, Favor T.; Awuah, Wireko A.; Anatoliivna, Sinkina A.; Volodymyrivna, Babar T.; Fedorivna, Herasymenko S.; Abdul-Rahman, Toufik] Sumy State Univ, Sumy, Ukraine.
   [Adebusoye, Favor T.] Sumy State Univ, Fac Med, Sanatorna St 31, UA-40000 Sumy, Sumy Oblast, Ukraine.
C3 Ministry of Education & Science of Ukraine; Sumy State University;
   Ministry of Education & Science of Ukraine; Sumy State University
RP Adebusoye, FT (corresponding author), Sumy State Univ, Fac Med, Sanatorna St 31, UA-40000 Sumy, Sumy Oblast, Ukraine.
EM i.nikitina@med.sumdu.edu.ua; Favouradebusoye@gmail.com;
   andyvans36@yahoo.com; best.ane4ka.best@gmail.com;
   t.babar@med.sumdu.edu.ua; s.herasymenko@med.sumdu.edu.ua;
   Drakelin24@gmail.com
RI WIREKO, ANDREW AWUAH/ABD-3005-2021
OI ADEBUSOYE, FAVOUR TOPE/0000-0001-5362-3920
CR Abu Alwafa R, 2021, BMC WOMENS HEALTH, V21, DOI 10.1186/s12905-021-01374-6
   Acheampong K, 2019, OBSTET GYNECOL INT, V2019, DOI 10.1155/2019/5834159
   AlHadi AN, 2022, INT J EAT DISORDER, V55, P1541, DOI 10.1002/eat.23790
   [Anonymous], 2022, Ukraine: civilian casualty update 24 October 2022. News
   Aoun A, 2013, GEN HOSP PSYCHIAT, V35, P393, DOI 10.1016/j.genhosppsych.2013.02.007
   Awuah WA, 2022, POSTGRAD MED J, V98, P408, DOI 10.1136/postgradmedj-2022-141801
   Bendavid E, 2021, LANCET, V397, P522, DOI 10.1016/S0140-6736(21)00131-8
   Boerma T, 2019, BMJ GLOB HEALTH, V4, DOI 10.1136/bmjgh-2018-001300
   Desroches S, 2007, APPL PHYSIOL NUTR ME, V32, P23, DOI 10.1139/h06-095
   Fiala C, 2017, EUR J CONTRACEP REPR, V22, P268, DOI 10.1080/13625187.2017.1334258
   Fourman LT, 2015, J CLIN ENDOCR METAB, V100, P812, DOI 10.1210/jc.2014-3344
   Hannoun AB, 2007, OBSTET GYNECOL, V109, P929, DOI 10.1097/01.AOG.0000257170.83920.de
   Holmes ME, 2016, J PHYS ACT HEALTH, V13, P1088, DOI 10.1123/jpah.2016-0041
   Janczura M, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0133750
   Maggioni A, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19127005
   Malitha JM, 2020, J PHYSIOL ANTHROPOL, V39, DOI 10.1186/s40101-020-00218-w
   Mathew G, 2021, INT J SURG, V96, DOI 10.1016/j.ijsu.2021.106165
   Operational Data Portal, UKR REF SIT
   Ritchie SA, 2007, NUTR METAB CARDIOVAS, V17, P319, DOI 10.1016/j.numecd.2006.07.005
   [Торшин Иван Юрьевич Torshin Ivan Yu.], 2019, [Акушерство и гинекология, Akusherstvo i ginekologiya], P156, DOI 10.18565/aig.2019.5.156-168
   unric.org, UN WAR UKRAINE KEY I
   Wiksten-Almströmer M, 2007, ACTA OBSTET GYN SCAN, V86, P65, DOI 10.1080/00016340601034970
   Zimmet P, 2007, LANCET, V369, P2059, DOI 10.1016/S0140-6736(07)60958-1
NR 23
TC 2
Z9 2
U1 2
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2049-0801
J9 ANN MED SURG
JI Ann. Med. Surg.
PD JUL
PY 2023
VL 85
IS 7
BP 3428
EP 3433
DI 10.1097/MS9.0000000000000974
PG 6
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA L7KO7
UT WOS:001025013800028
PM 37427173
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Poojari, PG
   Khan, S
   Shenoy, S
   Shetty, S
   Bose, S
   Pai, KSV
   Acharya, LD
   Thunga, G
AF Poojari, Pooja Gopal
   Khan, Sohil
   Shenoy, Sonia
   Shetty, Sahana
   Bose, Swarnali
   Pai, Keshava
   Acharya, Leelavathi D.
   Thunga, Girish
TI A narrative review of metabolic monitoring of adult prescribed
   second-generation antipsychotics for severe mental illness
SO CLINICAL EPIDEMIOLOGY AND GLOBAL HEALTH
LA English
DT Review
DE Early interventions; Metabolic syndrome; Cardiovascular disease; Mental
   health; Second generation antipsychotics
ID PHYSICAL HEALTH; INTERVENTION; MANAGEMENT; IMPACT; TRIAL; CARE
AB Introduction: Patients with severe mental illness (SMI) have poor physical wellbeing, leading essentially shorter lives, compared with the general population. Routine metabolic monitoring is proposed as a strategy for recognizing risk factors for metabolic variations in this population. This narrative review aimed to identify interventions at enhancing uptake of metabolic monitoring parameters in adult prescribed second generation antipsychotics (SGAs) for patients with SMI.Method: A literature search was performed through SCOPUS, PubMed, and CINAHL databases using a combination of keywords. We included primary studies published in the English language until December 2021 that provided evidence on interventions to increase the rate of SGAs related metabolic monitoring in patients with SMI. Results: A total of 21 studies were identified among which in 13 studies frequency of metabolic monitoring ranged between 40% and 80% after implementation of various strategies. These include multi-layer intervention model such as: (A) Reminders (e.g., paper-based prompts, invitation letter); (B) Electronic system of documentation (computer-based intervention, electronic medical records); (C) Healthcare practitioner specific role (Nurse-led intervention, pharmacist-led intervention, barrier focused strategies) and (D) Physical-mental health awareness (Education, quality improvement programme).Conclusion: This review provides evidence that studies involving the reminders such as paper based prompts and education to the patients as well as healthcare professionals could help in enhancing the rate of metabolic monitoring in patients prescribed SGAs.
C1 [Poojari, Pooja Gopal; Khan, Sohil; Acharya, Leelavathi D.; Thunga, Girish] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Dept Pharm Practice, Manipal 576104, Karnataka, India.
   [Khan, Sohil] Griffith Univ, Menzies Hlth Inst, Sch Pharm & Med Sci, Gold Coast, Australia.
   [Shenoy, Sonia] Manipal Acad Higher Educ, Kasturba Med Coll, Dept Psychiat, Manipal 576104, Karnataka, India.
   [Shetty, Sahana] Manipal Acad Higher Educ, Kasturba Med Coll, Dept Endocrinol, Manipal 576104, Karnataka, India.
   [Bose, Swarnali] Cent Inst Psychiat, Dept Clin Psychol, Ranchi 834006, Jharkhand, India.
   [Pai, Keshava] Kasturba Med Coll & Hosp, Dept Psychiat, Mangalore 575002, Karnataka, India.
C3 Manipal Academy of Higher Education (MAHE); Menzies Health Institute
   Queensland; Griffith University; Griffith University - Gold Coast
   Campus; Manipal Academy of Higher Education (MAHE); Kasturba Medical
   College, Manipal; Manipal Academy of Higher Education (MAHE); Kasturba
   Medical College, Manipal; Central Institute of Psychiatry; Manipal
   Academy of Higher Education (MAHE); Kasturba Medical College, Mangalore
RP Thunga, G (corresponding author), Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Dept Pharm Practice, Manipal 576104, Karnataka, India.
EM pooja.poojari@learner.manipal.edu; s.khan@griffith.edu.au;
   sonia.shenoy@manipal.edu; sahana.shetty@manipal.edu;
   swarnali.bose@rediffmail.com; pai.keshava@manipal.edu;
   leela.da@manipal.edu
RI Shenoy, Sonia/AAU-6047-2020; Shetty, Sahana/AAA-6271-2022; Pai,
   Keshava/LTE-0063-2024
OI Shetty, Sahana/0000-0003-0851-0411
CR [Anonymous], 2004, J CLIN PSYCHIAT, V65, P267
   Barnes TRE, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2015-007633
   Bomboy KT, 2021, J AM PSYCHIAT NURSES, V27, P162, DOI 10.1177/1078390320906196
   Cohen S, 2020, J CLIN PHARM THER, V45, P1398, DOI 10.1111/jcpt.13236
   Dayabandara M, 2017, NEUROPSYCH DIS TREAT, V13, DOI 10.2147/NDT.S113099
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P138
   DelMonte MT, 2012, J CLIN PHARM THER, V37, P668, DOI 10.1111/j.1365-2710.2012.01369.x
   Druss BG, 2010, AM J PSYCHIAT, V167, P151, DOI 10.1176/appi.ajp.2009.09050691
   Ferrara M, 2015, J PSYCHOPATHOL, V21, P269
   Gonzalez C, 2010, PSYCHIATR BULL, V34, P91, DOI 10.1192/pb.bp.108.021212
   Hardy Sheila, 2012, Prim Health Care Res Dev, V13, P347, DOI 10.1017/S1463423612000023
   Hor ESL, 2016, AUSTRALAS PSYCHIATRY, V24, P67, DOI 10.1177/1039856215604484
   Kioko E, 2016, ARCH PSYCHIAT NURS, V30, P671, DOI 10.1016/j.apnu.2016.03.004
   Kreyenbuhl J, 2017, COMMUNITY MENT HLT J, V53, P163, DOI 10.1007/s10597-016-0007-5
   Maki M, 2013, PERSPECT PSYCHIATR C, V49, P179, DOI 10.1111/j.1744-6163.2012.00348.x
   Michael S, 2020, BMJ OPEN QUAL, V9, DOI 10.1136/bmjoq-2019-000748
   Osborn DPJ, 2010, BMC HEALTH SERV RES, V10, DOI 10.1186/1472-6963-10-61
   Papanastasiou E, 2012, THER ADV ENDOCRINOL, V3, P141, DOI 10.1177/2042018812458697
   Pena Anita, 2018, Ment Health Clin, V8, P49, DOI 10.9740/mhc.2018.03.049
   Porter C, 2021, INT J MENT HEALTH NU, V30, P1417, DOI 10.1111/inm.12899
   Rosenbaum S, 2014, INT J MENT HEALTH NU, V23, P252, DOI 10.1111/inm.12057
   Thompson A, 2011, AUST NZ J PSYCHIAT, V45, P740, DOI 10.3109/00048674.2011.595370
   Tosh G, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008298.pub3
   Vasudev K, 2012, INT J HEALTH CARE Q, V25, P363, DOI 10.1108/09526861211221527
   Vasudev Kamini, 2010, Ment Health Fam Med, V7, P115
   Viglione L, 2021, AUSTRALAS PSYCHIATRY, V29, P289, DOI 10.1177/1039856220936147
   White J, 2011, TRIALS, V12, DOI 10.1186/1745-6215-12-167
   Wiechers IR, 2012, ACAD PSYCHIATR, V36, P118, DOI 10.1176/appi.ap.10090138
   Wilson E, 2014, AUSTRALAS PSYCHIATRY, V22, P248, DOI 10.1177/1039856214529000
   Yeomans D, 2014, PSYCHIATR BULL, V38, P280, DOI 10.1192/pb.bp.113.045955
NR 30
TC 5
Z9 6
U1 0
U2 1
PU ELSEVIER - DIVISION REED ELSEVIER INDIA PVT LTD
PI NEW DELHI
PA 17-A/1 MAIN RING ROAD, LAJPAT NAGAR IV, NEW DELHI, 110024, INDIA
SN 2452-0918
EI 2213-3984
J9 CLIN EPIDEMIOL GLOB
JI Clin. Epidemiol. Glob. Health
PD MAY-JUN
PY 2022
VL 15
AR 101035
DI 10.1016/j.cegh.2022.101035
EA MAR 2022
PG 8
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA 0Z7YD
UT WOS:000791288200024
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Dominiczak, MH
AF Dominiczak, MH
TI Obesity, glucose intolerance and diabetes and their links to
   cardiovascular disease. Implications for laboratory medicine
SO CLINICAL CHEMISTRY AND LABORATORY MEDICINE
LA English
DT Review
DE type 2 diabetes mellitus; obesity; cardiovascular disease; metabolic
   syndrome
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; FACTOR-KAPPA-B;
   INSULIN-RESISTANCE; RISK-FACTORS; OXIDATIVE STRESS; ENDOTHELIAL
   DYSFUNCTION; TRANSCRIPTION FACTOR; SIGNALING PATHWAYS; METABOLIC
   SYNDROME
AB This article provides an overview of the role of metabolite toxicity, lowgrade inflammation and disturbed cellular signaling in obesity, glucose intolerance and diabetes. It also highlights links between this continuum of deteriorating glucose tolerance and atherosclerosis.
   Obesity, diabetes mellitus, and cardiovascular disease are all related to diet and to the level of physical activity. They have reached epidemic proportions worldwide. Glucose intolerance and diabetes increase the risk of atherosclerotic events. Moreover, obesity, and glucose intolerance or diabetes, are components of the metabolic syndrome, which also imparts an increased cardiovascular risk. There is increasing recognition that common mechanisms contribute to diabetes and cardiovascular disease. Following increased calorie intake and/or decreased physical activity, fuel metabolism generates excess of toxic metabolites, particularly glucose and fatty acids. Homeostasis is affected by the endocrine output from the adipose tissue. Reactive oxygen species are generated, creating oxidative stress, which exerts major effects on signaling pathways, further affecting cellular metabolism and triggering lowgrade inflammatory reaction.
   This perspective on the diabetic syndrome has been reflected in the approach to its treatment, which integrates maintenance of glycemic control with primary and secondary cardiovascular prevention. Laboratory medicine should support diabetes care with an integrated package of tests which, in addition to glycemic control, enable assessment and monitoring of the risk of microvascular complications as well as cardiovascular disease.
C1 Gartnavel Royal Hosp, Dept Biochem, Glasgow G12 0YN, Lanark, Scotland.
   N Glasgow Univ Hosp NHS Trust, Med Humanities Unit, Glasgow, Lanark, Scotland.
C3 Gartnavel Royal Hospital; University of Glasgow
RP Gartnavel Royal Hosp, Dept Biochem, 1053 Great Western Rd, Glasgow G12 0YN, Lanark, Scotland.
EM m.h.dominiczak@clinmed.gla.ac.uk
CR Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   *AM DIAB ASS, 2003, DIABETES CARE, V26, pS80, DOI DOI 10.2337/DIACARE.26.2007.S80
   [Anonymous], 1993, N Engl J Med
   [Anonymous], DIABETES CARE
   [Anonymous], HDB LIPOPROTEIN TEST
   [Anonymous], 2001, JAMA, V285, P2486, DOI DOI 10.1001/JAMA.285.19.2486
   [Anonymous], 1998, BMJ, V317, P703, DOI DOI 10.1136/BMJ.317.7160.703
   Astrup A, 2000, Obes Rev, V1, P57, DOI 10.1046/j.1467-789x.2000.00013.x
   AUSTIN MA, 1990, CIRCULATION, V82, P495, DOI 10.1161/01.CIR.82.2.495
   Barnes PJ, 1997, NEW ENGL J MED, V336, P1066, DOI 10.1056/NEJM199704103361506
   Battisti WP, 2003, CLIN CHEM LAB MED, V41, P1174, DOI 10.1515/CCLM.2003.181
   Baynes JW, 1999, DIABETES, V48, P1, DOI 10.2337/diabetes.48.1.1
   BAYNES JW, 1991, DIABETES, V40, P405, DOI 10.2337/diabetes.40.4.405
   Bell GI, 2001, NATURE, V414, P788, DOI 10.1038/414788a
   Bierhaus A, 2001, DIABETES, V50, P2792, DOI 10.2337/diabetes.50.12.2792
   BODEN G, 1995, DIABETES, V44, P1239, DOI 10.2337/diabetes.44.10.1239
   BROWNLEE M, 1995, ANNU REV MED, V46, P223, DOI 10.1146/annurev.med.46.1.223
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Bucciarelli LG, 2002, CIRCULATION, V106, P2827, DOI 10.1161/01.CIR.0000039325.03698.36
   Campbell I., 2003, HEART, V89, P22
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   Cline GW, 1999, NEW ENGL J MED, V341, P240, DOI 10.1056/NEJM199907223410404
   Cohn JS, 1999, ARTERIOSCL THROM VAS, V19, P2474, DOI 10.1161/01.ATV.19.10.2474
   Diamond J, 2003, NATURE, V423, P599, DOI 10.1038/423599a
   Dominiczak MH, 2003, CURR OPIN LIPIDOL, V14, P329, DOI 10.1097/00041433-200306000-00013
   Dominiczak MH, 2001, CLIN CHEM LAB MED, V39, P907, DOI 10.1515/CCLM.2001.147
   Dominiczak MH, 2002, CURR OPIN LIPIDOL, V13, P343, DOI 10.1097/00041433-200206000-00016
   DOMINICZAK MH, 1999, MED BIOCH, P243
   DOMINICZAK MH, 1997, GLYCATION HYPOTHESIS, P1
   Du X, 2002, DIABETES, V51, pA175
   Engel S, 2003, NEW ENGL J MED, V348, P2294
   Evans JL, 2003, DIABETES, V52, P1, DOI 10.2337/diabetes.52.1.1
   Evans JMM, 2002, BRIT MED J, V324, P939, DOI 10.1136/bmj.324.7343.939
   *EXP COMM DIAGN CL, 2003, DIABETES CARE, V26, pS4
   FERRANNINI E, 1990, J CARDIOVASC PHARM, V15, pS18, DOI 10.1097/00005344-199000005-00004
   Festa A, 2002, DIABETES, V51, P1131, DOI 10.2337/diabetes.51.4.1131
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Ford ES, 1999, DIABETES CARE, V22, P1971, DOI 10.2337/diacare.22.12.1971
   Freeman DJ, 2002, DIABETES, V51, P1596, DOI 10.2337/diabetes.51.5.1596
   Gaede P, 2003, NEW ENGL J MED, V348, P383, DOI 10.1056/NEJMoa021778
   GARG A, 1988, METABOLISM, V37, P982, DOI 10.1016/0026-0495(88)90157-6
   Garg SK, 1999, DIABETES CARE, V22, P1708, DOI 10.2337/diacare.22.10.1708
   Gerich JE, 2003, MAYO CLIN PROC, V78, P447, DOI 10.4065/78.4.447
   GERSONY RD, 2000, HDB LIPOPROTEIN TEST, P31
   Ghilardi N, 1996, P NATL ACAD SCI USA, V93, P6231, DOI 10.1073/pnas.93.13.6231
   Gloyn AL, 2001, BEST PRACT RES CL EN, V15, P293, DOI 10.1053/beem.2001.0147
   Haffner SM, 1998, NEW ENGL J MED, V339, P229, DOI 10.1056/NEJM199807233390404
   Hanson RL, 2002, DIABETES, V51, P3120, DOI 10.2337/diabetes.51.10.3120
   Hardie LJ, 1996, HORM METAB RES, V28, P685, DOI 10.1055/s-2007-979878
   Harjai KJ, 1999, ANN INTERN MED, V131, P376, DOI 10.7326/0003-4819-131-5-199909070-00009
   Hermann C, 2000, ARTERIOSCL THROM VAS, V20, P402, DOI 10.1161/01.ATV.20.2.402
   Hofmann MA, 1998, DIABETES CARE, V21, P841, DOI 10.2337/diacare.21.5.841
   Horikawa Y, 2000, NAT GENET, V26, P163, DOI 10.1038/79876
   Hotamisligil GS, 1996, SCIENCE, V271, P665, DOI 10.1126/science.271.5249.665
   HUBERT HB, 1983, CIRCULATION, V67, P968, DOI 10.1161/01.CIR.67.5.968
   John WG, 2003, CLIN CHEM LAB MED, V41, P1199, DOI 10.1515/CCLM.2003.184
   Jorgensen LGM, 2003, CLIN CHEM LAB MED, V41, P1246, DOI 10.1515/CCLM.2003.191
   Kahn BB, 2000, J CLIN INVEST, V106, P473, DOI 10.1172/JCI10842
   Kern PA, 2000, DIABETES, V49, pA24
   Kernohan AFB, 2003, CLIN CHEM LAB MED, V41, P1239, DOI 10.1515/CCLM.2003.190
   King H, 1998, DIABETES CARE, V21, P1414, DOI 10.2337/diacare.21.9.1414
   Knowler William C, 2002, N Engl J Med, V346, P393, DOI 10.1056/NEJMoa012512
   Kobberling J., 1982, GENETICS DIABETES ME, P201
   Korshunov SS, 1997, FEBS LETT, V416, P15, DOI 10.1016/S0014-5793(97)01159-9
   LAAKSO M, 1989, ARTERIOSCLEROSIS, V9, P665, DOI 10.1161/01.ATV.9.5.665
   Leary ET, 1998, CLIN CHEM, V44, P2490
   Liebl A, 2002, DIABETES-METAB RES, V18, pS36, DOI 10.1002/dmrr.286
   Lindsay RS, 2002, LANCET, V360, P57, DOI 10.1016/S0140-6736(02)09335-2
   Little RR, 2003, CLIN CHEM LAB MED, V41, P1191, DOI 10.1515/CCLM.2003.183
   Liuzzo G, 2001, Rays, V26, P221
   Manley S, 2003, CLIN CHEM LAB MED, V41, P1182, DOI 10.1515/CCLM.2003.182
   Mann JI, 2002, LANCET, V360, P783, DOI 10.1016/S0140-6736(02)09901-4
   Marcucci M, 1998, DIABETES, V47, pA284
   Mastrototaro J, 1999, J PEDIATR ENDOCR MET, V12, P751
   McGarry JD, 2002, DIABETES, V51, P7, DOI 10.2337/diabetes.51.1.7
   Meigs JB, 2000, JAMA-J AM MED ASSOC, V283, P221, DOI 10.1001/jama.283.2.221
   Meigs JB, 2003, BRIT MED J, V327, P61, DOI 10.1136/bmj.327.7406.61
   Miyata T, 2003, CLIN CHEM LAB MED, V41, P1150, DOI 10.1515/CCLM.2003.178
   MODAN M, 1985, J CLIN INVEST, V75, P809, DOI 10.1172/JCI111776
   Mooradian AD, 2003, ARCH INTERN MED, V163, P33, DOI 10.1001/archinte.163.1.33
   Mora S, 2002, DIABETES-METAB RES, V18, P345, DOI 10.1002/dmrr.321
   Must A, 1999, JAMA-J AM MED ASSOC, V282, P1523, DOI 10.1001/jama.282.16.1523
   NAKAMURA Y, 1993, AM J PATHOL, V143, P1649
   NEIL A, 1993, DIABETES CARE, V16, P996, DOI 10.2337/diacare.16.7.996
   Nishikawa T, 2000, NATURE, V404, P787, DOI 10.1038/35008121
   PALMER RMJ, 1987, NATURE, V327, P524, DOI 10.1038/327524a0
   Pan DA, 1997, DIABETES, V46, P983, DOI 10.2337/diabetes.46.6.983
   Parving HH, 1998, DIABETOLOGIA, V41, P745, DOI 10.1007/s001250050983
   Pearson TA, 2003, CIRCULATION, V107, P499, DOI 10.1161/01.CIR.0000052939.59093.45
   Piconi L, 2003, CLIN CHEM LAB MED, V41, P1144, DOI 10.1515/CCLM.2003.177
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Price CP, 2003, CLIN CHEM LAB MED, V41, P1213, DOI 10.1515/CCLM.2003.185
   Pyorala K, 1997, DIABETES CARE, V20, P614, DOI 10.2337/diacare.20.4.614
   RAPP JH, 1994, ARTERIOSCLER THROMB, V14, P1767, DOI 10.1161/01.ATV.14.11.1767
   Ridker PM, 1999, ANN INTERN MED, V130, P933, DOI 10.7326/0003-4819-130-11-199906010-00018
   Ridker PM, 1998, CIRCULATION, V98, P731, DOI 10.1161/01.CIR.98.8.731
   Ridker PM, 2000, NEW ENGL J MED, V342, P836, DOI 10.1056/NEJM200003233421202
   ROITT I, 1998, IMMUNOLOGY, P1
   ROSS R, 1993, NATURE, V362, P801, DOI 10.1038/362801a0
   Sacks DB, 2002, CLIN CHEM, V48, P436, DOI 10.2337/dc11-9998
   Sacks DB, 2002, DIABETES CARE, V25, P750, DOI 10.2337/diacare.25.4.750
   SALADIN R, 1995, NATURE, V377, P527, DOI 10.1038/377527a0
   Saltiel AR, 2001, NATURE, V414, P799, DOI 10.1038/414799a
   Savage PJ, 1996, ANN INTERN MED, V124, P123, DOI 10.7326/0003-4819-124-1_Part_2-199601011-00008
   Schiekofer S, 2003, DIABETES, V52, P621, DOI 10.2337/diabetes.52.3.621
   SCHMIDT AM, 1995, J CLIN INVEST, V96, P1395, DOI 10.1172/JCI118175
   Schmidt AM, 2001, J CLIN INVEST, V108, P949, DOI 10.1172/JCI14002
   SCHMIDT AM, 1992, J BIOL CHEM, V267, P14987
   Schmidt MI, 2003, CLIN CHEM LAB MED, V41, P1120, DOI 10.1515/CCLM.2003.174
   Schmidt MI, 1999, LANCET, V353, P1649, DOI 10.1016/S0140-6736(99)01046-6
   Semenkovich CF, 1997, DIABETES, V46, P327, DOI 10.2337/diabetes.46.3.327
   Stec JJ, 2000, CIRCULATION, V102, P1634, DOI 10.1161/01.CIR.102.14.1634
   Stehouwer CDA, 2001, CLIN CHEM LAB MED, V39, P705, DOI 10.1515/CCLM.2001.116
   Steinberger J, 2003, CIRCULATION, V107, P1448, DOI 10.1161/01.CIR.0000060923.07573.F2
   STERN MP, 1995, DIABETES, V44, P369, DOI 10.2337/diabetes.44.4.369
   Stratton IM, 2000, BMJ-BRIT MED J, V321, P405, DOI 10.1136/bmj.321.7258.405
   Straub SG, 2002, DIABETES-METAB RES, V18, P451, DOI 10.1002/dmrr.329
   Tschritter O, 2003, DIABETES, V52, P239, DOI 10.2337/diabetes.52.2.239
   Tuomilehto J, 2001, NEW ENGL J MED, V344, P1343, DOI 10.1056/NEJM200105033441801
   Turner RC, 1998, LANCET, V352, P837, DOI 10.1016/s0140-6736(98)07019-6
   UNGER RH, 1995, DIABETES, V44, P863, DOI 10.2337/diabetes.44.8.863
   Unger RH, 2002, ANNU REV MED, V53, P319, DOI 10.1146/annurev.med.53.082901.104057
   VLASSARA H, 1995, MOL MED, V1, P447, DOI 10.1007/BF03401582
   VLASSARA H, 1988, SCIENCE, V240, P1546, DOI 10.1126/science.3259727
   Vlassara H, 2002, P NATL ACAD SCI USA, V99, P15596, DOI 10.1073/pnas.242407999
   Vollenweider P, 2003, CLIN CHEM LAB MED, V41, P1107, DOI 10.1515/CCLM.2003.173
   Whicher J, 1999, CLIN CHEM LAB MED, V37, P495, DOI 10.1515/CCLM.1999.080
   WOLFF SP, 1987, BIOCHEM J, V245, P243, DOI 10.1042/bj2450243
   YARNELL JWG, 1991, CIRCULATION, V83, P836, DOI 10.1161/01.CIR.83.3.836
   Yeromenko Y, 2001, NUTR METAB CARDIOVAS, V11, P108
   Yudkin JS, 1999, ARTERIOSCL THROM VAS, V19, P972, DOI 10.1161/01.ATV.19.4.972
   Zhang HH, 2000, MOL CELL ENDOCRINOL, V159, P79, DOI 10.1016/S0303-7207(99)00194-X
   Zimmet P, 2001, NATURE, V414, P782, DOI 10.1038/414782a
NR 133
TC 31
Z9 38
U1 0
U2 6
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1434-6621
EI 1437-4331
J9 CLIN CHEM LAB MED
JI Clin. Chem. Lab. Med.
PY 2003
VL 41
IS 9
BP 1266
EP 1278
DI 10.1515/CCLM.2003.194
PG 13
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 722TD
UT WOS:000185392000024
PM 14598880
DA 2025-06-11
ER

PT J
AU Barton, BB
   Segger, F
   Fischer, K
   Obermeier, M
   Musil, R
AF Barton, Barbara B.
   Segger, Felix
   Fischer, Kai
   Obermeier, Michael
   Musil, Richard
TI Update on weight-gain caused by antipsychotics: a systematic review and
   meta-analysis
SO EXPERT OPINION ON DRUG SAFETY
LA English
DT Review
DE Aripiprazole; asenapine; brexpiprazole; cariprazine; lurasidone; number
   needed to harm; olanzapine; quetiapine extended release; risperidone;
   transdiagnostically
ID PLACEBO-CONTROLLED TRIAL; EXTENDED-RELEASE QUETIAPINE; BIPOLAR I
   DEPRESSION; DOUBLE-BLIND; ACUTE EXACERBATION; 2ND-GENERATION
   ANTIPSYCHOTICS; ATYPICAL ANTIPSYCHOTICS; ASIAN PATIENTS; RISK-FACTORS;
   ACUTE MANIA
AB Introduction: Antipsychotic-induced weight-gain (AIWG) is a very important, yet often neglected side-effect in the treatment with first and second generation antipsychotics. AIWG can increase the risk of developing metabolic syndrome, diabetes and cardiovascular disease. Meta-analyzes mostly concentrate on AIWG in schizophrenic and bipolar patients, even though antipsychotics are prescribed off-label across many other diagnostic groups (e.g. anxiety disorders, depression, autistic disorder). Areas covered: Pub Med and Web of Science were systematically searched for RCTs reporting on AIWG with a sample size of >= 100 published between 2014 and 2019. All diagnoses and ages were included. Expert opinion: Inclusion criteria were fulfilled by 27 RCTs. All antipsychotics led to significantly more weight-gain (p < .001) and most antipsychotics led to a significantly higher risk for a clinically relevant weight-gain of >= 7% compared to placebo (RR = 2.04). The results support previous findings that weight-gain occurs quickly. To efficaciously and efficiently tackle the problem of AIWG in clinical practice and trials, people at high risk need to be identified by predictive tools enabling the clinician to offer tailored adjunctive therapies (medication and/or lifestyle interventions). Most importantly, weight and metabolic monitoring ought to be consequently implemented in clinical routine in the treatment of any patient with any diagnosis when antipsychotics are prescribed.
C1 [Barton, Barbara B.; Segger, Felix; Fischer, Kai; Musil, Richard] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Nussbaumstr 7, D-80336 Munich, Germany.
   [Obermeier, Michael] Gesell Therapieforsch MbH, GKM, Munich, Germany.
C3 University of Munich
RP Barton, BB (corresponding author), Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Nussbaumstr 7, D-80336 Munich, Germany.
EM barbara.barton@med.uni-muenchen.de
RI Musil, Richard/AAF-4331-2020
CR Allison DB, 2009, PSYCHIAT RES, V170, P172, DOI 10.1016/j.psychres.2008.10.007
   Allison DB, 1999, AM J PSYCHIAT, V156, P1686
   Almandil NB, 2013, PEDIATR DRUGS, V15, P139, DOI 10.1007/s40272-013-0016-6
   Bak M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094112
   Berling I, 2016, BRIT J CLIN PHARMACO, V82, P249, DOI 10.1111/bcp.12927
   Black DW, 2014, AM J PSYCHIAT, V171, P1174, DOI 10.1176/appi.ajp.2014.13101348
   Bobo WV, 2013, JAMA PSYCHIAT, V70, P1067, DOI 10.1001/jamapsychiatry.2013.2053
   Bruins J, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0112276
   Bushe CJ, 2013, J PSYCHOPHARMACOL, V27, P358, DOI 10.1177/0269881112473789
   Calabrese JR, 2015, J CLIN PSYCHIAT, V76, P284, DOI 10.4088/JCP.14m09081
   Carliner H, 2014, COMPR PSYCHIAT, V55, P233, DOI 10.1016/j.comppsych.2013.09.009
   Carr Chelsea N, 2016, Ment Health Clin, V6, P308, DOI 10.9740/mhc.2016.11.308
   Cerovecki A, 2013, CNS DRUGS, V27, P545, DOI 10.1007/s40263-013-0079-5
   Corponi F, 2019, EUR NEUROPSYCHOPHARM, V29, P971, DOI 10.1016/j.euroneuro.2019.06.008
   Correll CU, 2015, AM J PSYCHIAT, V172, P870, DOI 10.1176/appi.ajp.2015.14101275
   Correll CU, 2015, WORLD PSYCHIATRY, V14, P56, DOI 10.1002/wps.20187
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   DelBello MP, 2017, J AM ACAD CHILD PSY, V56, P1015, DOI 10.1016/j.jaac.2017.10.006
   DERSIMONIAN R, 1986, CONTROL CLIN TRIALS, V7, P177, DOI 10.1016/0197-2456(86)90046-2
   *DGPPN E.V, 2019, LANGF
   Driessen J, 2016, PSYCHIAT SERV, V67, P898, DOI 10.1176/appi.ps.201500316
   Duncan D, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2015-010861
   Durgam S, 2016, AM J PSYCHIAT, V173, P271, DOI 10.1176/appi.ajp.2015.15020164
   Durgam S, 2015, J CLIN PSYCHIAT, V76, pE1574, DOI 10.4088/JCP.15m09997
   Durgam S, 2015, BIPOLAR DISORD, V17, P63, DOI 10.1111/bdi.12238
   Durgam S, 2014, SCHIZOPHR RES, V152, P450, DOI 10.1016/j.schres.2013.11.041
   Earley W, 2019, AM J PSYCHIAT, V176, P439, DOI 10.1176/appi.ajp.2018.18070824
   Findling RL, 2014, J CHILD ADOL PSYCHOP, V24, P325, DOI 10.1089/cap.2013.0105
   Gao KM, 2016, J CLIN PSYCHOPHARM, V36, P637, DOI 10.1097/JCP.0000000000000596
   Gebhardt S, 2009, J PSYCHIATR RES, V43, P620, DOI 10.1016/j.jpsychires.2008.11.001
   Gentile S, 2009, OBES REV, V10, P527, DOI 10.1111/j.1467-789X.2009.00589.x
   Goldman R, 2017, J CHILD ADOL PSYCHOP, V27, P516, DOI 10.1089/cap.2016.0189
   Higgins JP., 2003, BMJ, V327, P557, DOI [10.1136/bmj.327.7414.557, DOI 10.1136/BMJ.327.7414.557]
   Higuchi T, 2019, ASIA-PAC PSYCHIAT, V11, DOI 10.1111/appy.12354
   Huhn M, 2019, LANCET, V394, P939, DOI [10.1016/S0140-6736(19)31135-3, 10.1176/appi.focus.18306]
   Ishigooka J, 2018, PSYCHIAT CLIN NEUROS, V72, P692, DOI 10.1111/pcn.12682
   Kanba S, 2014, WORLD J BIOL PSYCHIA, V15, P113, DOI 10.3109/15622975.2012.669047
   Kane JM, 2015, SCHIZOPHR RES, V164, P127, DOI 10.1016/j.schres.2015.01.038
   Kane JM, 2014, J CLIN PSYCHIAT, V75, P1254, DOI 10.4088/JCP.14m09168
   Kinoshita T, 2016, PSYCHOPHARMACOLOGY, V233, P2663, DOI 10.1007/s00213-016-4295-9
   LAWRENCE D, 2013, BMJ BRIT MED J, V346
   Lee E, 2004, J CLIN PSYCHIAT, V65, P864
   Leucht S, 2013, LANCET, V382, P951, DOI 10.1016/S0140-6736(13)60733-3
   Li HF, 2016, PSYCHOPHARMACOLOGY, V233, P1289, DOI 10.1007/s00213-016-4215-z
   Loebel A, 2016, J CLIN PSYCHIAT, V77, P1672, DOI 10.4088/JCP.16m10698
   Loebel A, 2016, J AUTISM DEV DISORD, V46, P1153, DOI 10.1007/s10803-015-2628-x
   Loebel A, 2014, AM J PSYCHIAT, V171, P160, DOI 10.1176/appi.ajp.2013.13070984
   Loebel AD, 2014, CNS SPECTRUMS, V19, P197, DOI 10.1017/S1092852913000904
   Mahendran R, 2010, ANN ACAD MED SINGAP, V39, P118
   Maher AR, 2011, JAMA-J AM MED ASSOC, V306, P1359, DOI 10.1001/jama.2011.1360
   Matei VP, 2016, ACTA ENDOCRINOL-BUCH, V12, P177, DOI 10.4183/aeb.2016.177
   McIntyre A, 2014, ARTHRITIS RHEUMATOL, V66, P451, DOI 10.1002/art.38228
   Meltzer HY, 2015, J CLIN PSYCHIAT, V76, P1085, DOI 10.4088/JCP.14m09741
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Moteshafi H, 2012, DRUG SAFETY, V35, P819, DOI 10.2165/11631510-000000000-00000
   Murasaki M, 2018, PSYCHOPHARMACOLOGY, V235, P3079, DOI 10.1007/s00213-018-5013-6
   Musil R, 2015, EXPERT OPIN DRUG SAF, V14, P73, DOI 10.1517/14740338.2015.974549
   Pandit R, 2019, ACTA PSYCHIAT SCAND, V140, P283, DOI 10.1111/acps.13074
   Parsons B, 2009, SCHIZOPHR RES, V110, P103, DOI 10.1016/j.schres.2008.09.025
   Potkin SG, 2017, SCHIZOPHR RES, V190, P115, DOI 10.1016/j.schres.2017.03.003
   *R FDN STAT COMP, 2019, R VERS 3 6 1 R LANG
   Sachs GS, 2015, J AFFECT DISORDERS, V174, P296, DOI 10.1016/j.jad.2014.11.018
   Sallee F, 2017, J CHILD ADOL PSYCHOP, V27, P771, DOI 10.1089/cap.2016.0026
   Shen JHQ, 2014, J PSYCHIATR RES, V53, P14, DOI 10.1016/j.jpsychires.2014.02.012
   Simon V, 2009, J CLIN PSYCHIAT, V70, P1041, DOI 10.4088/JCP.08r04392
   Slagter SN, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0140599
   Spertus J, 2018, NPJ SCHIZOPHR, V4, DOI 10.1038/s41537-018-0053-9
   Suppes T, 2016, AM J PSYCHIAT, V173, P400, DOI 10.1176/appi.ajp.2015.15060770
   Szegedi A, 2018, AM J PSYCHIAT, V175, P71, DOI 10.1176/appi.ajp.2017.16040419
   Tandon R, 2016, J PSYCHOPHARMACOL, V30, P69, DOI 10.1177/0269881115620460
   Tarricone I, 2010, PSYCHOL MED, V40, P187, DOI 10.1017/S0033291709990407
   Tek C, 2016, EARLY INTERV PSYCHIA, V10, P193, DOI 10.1111/eip.12251
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vandenberghe F, 2018, J CHILD ADOL PSYCHOP, V28, P258, DOI 10.1089/cap.2017.0038
   Vandenberghe F, 2015, J CLIN PSYCHIAT, V76, pE1417, DOI 10.4088/JCP.14m09358
   Wandell P, 2014, J PSYCHOSOM RES, V77, P169, DOI 10.1016/j.jpsychores.2014.06.012
   Wang G, 2016, NEUROPSYCH DIS TREAT, V12, P2077, DOI 10.2147/NDT.S98927
   Wang G, 2014, NEUROPSYCH DIS TREAT, V10, P201, DOI 10.2147/NDT.S50248
   Zhang JP, 2016, SCHIZOPHRENIA BULL, V42, P1418, DOI 10.1093/schbul/sbw058
   Zhou XY, 2015, INT J NEUROPSYCHOPH, V18, DOI 10.1093/ijnp/pyv060
NR 80
TC 148
Z9 154
U1 0
U2 39
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1474-0338
EI 1744-764X
J9 EXPERT OPIN DRUG SAF
JI Expert Opin. Drug Saf.
PD MAR 3
PY 2020
VL 19
IS 3
BP 295
EP 314
DI 10.1080/14740338.2020.1713091
EA MAR 2020
PG 20
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy
GA MB1QS
UT WOS:000519515000001
PM 31952459
DA 2025-06-11
ER

PT J
AU Zhou, Q
   Zhou, LJ
   Chen, X
   Chen, QY
   Hao, L
AF Zhou, Qing
   Zhou, Lijun
   Chen, Xi
   Chen, Qiuyan
   Hao, Lu
TI Composite dietary antioxidant index is associated with reduced
   prevalence of metabolic syndrome but not mortality in metabolic
   syndrome: Results from NHANES 2001-2018
SO PREVENTIVE MEDICINE REPORTS
LA English
DT Article
DE Metabolic syndrome; NHANES; Diet; Antioxidants; Mortality
ID MODERATE ALCOHOL-CONSUMPTION; OXIDATIVE STRESS; RISK
AB The relationship between the composite dietary antioxidant index (CDAI), a comprehensive measure of individual dietary antioxidants, and the prevalence and mortality of metabolic syndrome (MetS) remains unknown. We aimed to explore these relationships in the National Health and Nutrition Examination Survey (NHANES). We explored these relationships using two independent cohorts. First, we addressed CDAI and the prevalence of MetS in the general population; second, we explored the association between CDAI and mortality in patients with MetS by following NHANES 2001-2018 participants through December 31, 2019. In addition, restricted cubic spline (RCS), stratified analysis, and sensitivity analysis were used for further interpretation. We included 24,514 participants aged 20-85 years, in which the prevalence of MetS was 27.61 %. CDAI was negatively and doseresponsively associated with the prevalence of MetS, however it was not associated with mortality in patients with MetS. In addition, CDAI was associated with a reduced prevalence of certain components of MetS, including dyslipidemia and central obesity. RCS showed a linear correlation between CDAI and MetS and the above components. Stratified analyses indicated that alcohol consumption was a significant influence of CDAI-MetS and that socioeconomic status and lifestyle specificity existed. Sensitivity analysis confirmed the stability of the results. CDAI was protective against the development of MetS in the general population, but not against mortality in patients with MetS. Clinicians need to develop individualized prevention strategies to reduce the development of MetS by modifying CDAI.
C1 [Zhou, Qing; Chen, Xi] Peoples Hosp Baoan Shenzhen, Cent Lab, Shenzhen, Peoples R China.
   [Zhou, Lijun] Peoples Hosp Baoan Shenzhen, Dept Urol, Shenzhen, Peoples R China.
   [Chen, Qiuyan; Hao, Lu] Shenzhen Baoan Shiyan Peoples Hosp, Sci & Educ Dept, Shenzhen, Peoples R China.
RP Hao, L (corresponding author), Shenzhen Baoan Shiyan Peoples Hosp, Sci & Educ Dept, Shenzhen, Peoples R China.
EM haolu8686@sina.com
CR Al-Khatib Y, 2022, CUREUS J MED SCIENCE, V14, DOI 10.7759/cureus.22153
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Bacchetti T, 2019, NUTRITION, V61, P164, DOI 10.1016/j.nut.2018.10.034
   Bahadoran Z, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-70
   Behrendt I, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9121287
   Bovolini A, 2021, INT J SPORTS MED, V42, P199, DOI 10.1055/a-1263-0898
   Cardoso BR, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.696024
   Chen XJ, 2023, DIABETOL METAB SYNDR, V15, DOI 10.1186/s13098-023-01150-6
   De Sousa SMC, 2016, BEST PRACT RES CL OB, V37, P140, DOI 10.1016/j.bpobgyn.2016.01.006
   Deng XY, 2023, FRONT PUBLIC HEALTH, V10, DOI 10.3389/fpubh.2022.1047605
   Dietrich P, 2014, BEST PRACT RES CL GA, V28, P637, DOI 10.1016/j.bpg.2014.07.008
   Ding J, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.825913
   Francisqueti FV, 2017, REV ASSOC MED BRAS, V63, P85
   Gigleux I, 2006, J NUTR, V136, P3027, DOI 10.1093/jn/136.12.3027
   Hartman TJ, 2005, EUR J CLIN NUTR, V59, P161, DOI 10.1038/sj.ejcn.1602051
   Hicks CW, 2021, ANN INTERN MED, V174, P167, DOI 10.7326/M20-1340
   Johnson Clifford L, 2013, Vital Health Stat 2, P1
   Kane AE, 2017, GEROSCIENCE, V39, P221, DOI 10.1007/s11357-017-9967-9
   Kim SA, 2019, NUTR J, V18, DOI 10.1186/s12937-019-0459-x
   Klarich DS, 2017, ALCOHOL, V61, P25, DOI 10.1016/j.alcohol.2017.02.179
   Liang XP, 2023, POSTGRAD MED J, V99, P985, DOI 10.1093/postmj/qgad008
   Liu XH, 2022, BIOL TRACE ELEM RES, V200, P3041, DOI 10.1007/s12011-021-02912-x
   Lopez-Legarrea P, 2013, NUTR METAB, V10, DOI 10.1186/1743-7075-10-22
   Luu HN, 2015, ANTIOXID REDOX SIGN, V22, P951, DOI 10.1089/ars.2014.6212
   Magherman L, 2023, ALIMENT PHARM THER, V57, P820, DOI 10.1111/apt.17388
   Mancini A, 2015, CLIN NUTR ESPEN, V10, pE52, DOI 10.1016/j.clnesp.2014.11.002
   Masenga SK, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24097898
   Monteiro R, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/289645
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Otto MCD, 2012, J NUTR, V142, P526, DOI 10.3945/jn.111.149781
   Puchau B, 2010, NUTRITION, V26, P534, DOI 10.1016/j.nut.2009.06.017
   Ranasinghe P, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4041-1
   Retondario A, 2019, CLIN NUTR, V38, P603, DOI 10.1016/j.clnu.2018.02.021
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Wang WJ, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.849727
   Wang Y, 2018, NUTRIENTS, V10, DOI 10.3390/nu10050572
   Wei J, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0130876
   Wright ME, 2004, AM J EPIDEMIOL, V160, P68, DOI 10.1093/aje/kwh173
   Wu DZ, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1147869
   Wu MY, 2023, CLIN EXP HYPERTENS, V45, DOI 10.1080/10641963.2023.2233712
   Yu YC, 2022, INT J CANCER, V150, P1599, DOI 10.1002/ijc.33925
   Zhang X, 2017, TRANSL RES, V183, P14, DOI 10.1016/j.trsl.2016.12.004
NR 43
TC 9
Z9 9
U1 4
U2 21
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2211-3355
J9 PREV MED REP
JI Prev. Med. Rep.
PD MAY
PY 2024
VL 41
AR 102704
DI 10.1016/j.pmedr.2024.102704
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA QL2L8
UT WOS:001220963000001
PM 38576515
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Merabet, N
   Fang, YH
   Nicol, L
   Monteil, C
   Rémy-Jouet, I
   Henry, JP
   Wecker, D
   Le Bouter-Banon, S
   Roussel, J
   Richard, V
   Thuillez, C
   Mulder, P
AF Merabet, Nassiba
   Fang, Yuehua
   Nicol, Lionel
   Monteil, Christelle
   Remy-Jouet, Isabelle
   Henry, Jean-Paul
   Wecker, Didier
   Le Bouter-Banon, Sabrina
   Roussel, Jerome
   Richard, Vincent
   Thuillez, Christian
   Mulder, Paul
TI Selective Heart Rate Reduction Improves Metabolic Syndrome-related Left
   Ventricular Diastolic Dysfunction
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
LA English
DT Article
DE diastolic function; metabolic syndrome; heart rate reduction
ID CORONARY-ARTERY-DISEASE; FAILING DIABETIC HEART; OXIDATIVE STRESS;
   ENDOTHELIAL DYSFUNCTION; NITRIC-OXIDE; CONTRACTILE DYSFUNCTION;
   BRADYCARDIAC AGENT; BLOOD-FLOW; IVABRADINE; FAILURE
AB Background: Enhanced heart rate observed in metabolic syndrome ( MS) contributes to the deterioration of left ventricular ( LV) function via impaired LV filling and relaxation, increased myocardial O-2 consumption, and reduced coronary perfusion. However, whether heart rate reduction (HRR) opposes LV dysfunction observed in MS is unknown. Methods: We assessed in Zucker fa/fa rats, a rat model of MS, the cardiovascular effects of HRR induced by the If current inhibitor S38844 ( 3 mg center dot kg21 center dot d(-1)). Results: Delayed short-term ( 4 days) and long-term ( 90 days) HRR induced by S38844 reduced LV end-diastolic pressure and LV enddiastolic pressure-volume relation, increased myocardial tissue perfusion, decreased myocardial oxidized glutathione levels, and preserved cardiac output, without modifying LV end-systolic pressure and LV end-systolic pressure-volume relation, although only long-term S38844 opposed LV collagen accumulation. Long-term S38844 improved flow-induced endothelium-dependent dilatation of mesenteric arteries, while metabolic parameters, such as plasma glucose levels, and Hb1c, were never modified. Conclusions: In rats with MS, HRR induced by the If inhibitor S38844 improved LV diastolic function and endothelium- dependent vascular dilatation, independent from modifications in metabolic status. Moreover, this improvement in cardiac function involves not only immediate effects such as improved myocardial perfusion and reduced oxidative stress but also long- term effects such as modifications in the myocardial structure.
C1 [Merabet, Nassiba; Fang, Yuehua; Nicol, Lionel; Monteil, Christelle; Remy-Jouet, Isabelle; Henry, Jean-Paul; Richard, Vincent; Thuillez, Christian; Mulder, Paul] INSERM, U1096, Rouen, France.
   [Merabet, Nassiba; Fang, Yuehua; Nicol, Lionel; Remy-Jouet, Isabelle; Henry, Jean-Paul; Richard, Vincent; Thuillez, Christian; Mulder, Paul] Inst Res & Innovat Biomed, Rouen, France.
   [Merabet, Nassiba; Fang, Yuehua; Nicol, Lionel; Monteil, Christelle; Remy-Jouet, Isabelle; Henry, Jean-Paul; Richard, Vincent; Thuillez, Christian; Mulder, Paul] Univ Rouen, UFR Med & Pharm, Rouen, France.
   [Nicol, Lionel; Thuillez, Christian; Mulder, Paul] Univ Rouen, Plateau Imagerie CardioThorac, Rouen, France.
   [Monteil, Christelle] Equipe Acceuil 4651, Aliment Bioproc Toxicol Environm, Rouen, France.
   [Wecker, Didier] Bruker Biospin MRI GMBH, Ettlingen, Germany.
   [Le Bouter-Banon, Sabrina; Roussel, Jerome] Servier, Suresnes, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Rouen Normandie; Universite de Rouen Normandie; Universite
   de Rouen Normandie; Bruker Corporation; Bruker BioSpin GmbH
RP Mulder, P (corresponding author), UFR Med & Pharm, INSERM U1096, 22 Blvd Gambetta, F-76183 Rouen, France.
EM paul.mulder@univ-rouen.fr
RI Monteil, Christelle/ABF-3312-2022; Richard, Vincent/B-1059-2014
OI Mulder, Paul/0000-0002-5936-5704; Richard, Vincent/0000-0003-0590-0158;
   Monteil, Christelle/0000-0002-4981-0800
FU SERVIER; FEDER
FX Supported by a research grant of SERVIER and FEDER. Moreover, assistance
   of Elodie Gomez and Ji Gao and Julie Favre was gratefully acknowledged.
CR Aebi H, 1984, Methods Enzymol, V105, P121
   Banquet S, 2011, CIRCULATION, V124, P1059, DOI 10.1161/CIRCULATIONAHA.110.010264
   BOUDOULAS H, 1979, J CARDIOVASC PHARM, V1, P503, DOI 10.1097/00005344-197909000-00003
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Canet E, 2011, ANN NY ACAD SCI, V1222, P90, DOI 10.1111/j.1749-6632.2011.05960.x
   Chess DJ, 2007, AM J PHYSIOL-HEART C, V293, pH1853, DOI 10.1152/ajpheart.00544.2007
   Couvreur N, 2010, EUR HEART J, V31, P1529, DOI 10.1093/eurheartj/ehp554
   Crapo J D, 1978, Methods Enzymol, V53, P382
   Custodis F, 2008, CIRCULATION, V117, P2377, DOI 10.1161/CIRCULATIONAHA.107.746537
   Drouin A, 2008, BRIT J PHARMACOL, V154, P749, DOI 10.1038/bjp.2008.116
   El-Kholy W, 2007, MOL ENDOCRINOL, V21, P753, DOI 10.1210/me.2006-0258
   El-Omar MM, 2003, EUR J HEART FAIL, V5, P229, DOI 10.1016/S1388-9842(03)00010-2
   Fang YH, 2012, J CARDIOVASC PHARM, V59, P260, DOI 10.1097/FJC.0b013e31823e5e01
   Fang YH, 2011, J MOL CELL CARDIOL, V51, P168, DOI 10.1016/j.yjmcc.2011.05.012
   Ford ES, 2004, ATHEROSCLEROSIS, V173, P309, DOI 10.1016/j.atherosclerosis.2003.12.022
   Fox K, 2008, LANCET, V372, P807, DOI 10.1016/S0140-6736(08)61170-8
   Fraccarollo D, 2008, CIRCULATION, V118, P818, DOI 10.1161/CIRCULATIONAHA.107.717702
   GILLEBERT TC, 1992, AM J PHYSIOL, V263, pH857, DOI 10.1152/ajpheart.1992.263.3.H857
   Grassi G, 2007, HYPERTENSION, V49, P535, DOI 10.1161/01.HYP.0000255983.32896.b9
   GUTH B D, 1987, European Heart Journal, V8, P61
   GUTH BD, 1987, CIRCULATION, V75, P661, DOI 10.1161/01.CIR.75.3.661
   GUTH BD, 1990, BASIC RES CARDIOL, V85, P157
   Heusch G, 2008, BRIT J PHARMACOL, V153, P1589, DOI 10.1038/sj.bjp.0707673
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jain M, 2003, CIRC RES, V93, pE9, DOI 10.1161/01.RES.0000083489.83704.76
   Kapadia S R, 1999, Cardiol Rev, V7, P196, DOI 10.1097/00045415-199907000-00011
   Kim CH, 2002, CIRC RES, V90, pE25, DOI 10.1161/hh0202.104923
   Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213
   Kober F, 2005, MAGNET RESON MED, V53, P601, DOI 10.1002/mrm.20373
   Krüger C, 2000, CARDIOVASC RES, V45, P900, DOI 10.1016/S0008-6363(99)00405-8
   Kuster GM, 2010, FREE RADICAL BIO MED, V48, P1182, DOI 10.1016/j.freeradbiomed.2010.01.038
   LITWIN SE, 1994, CIRCULATION, V89, P345, DOI 10.1161/01.CIR.89.1.345
   Lopaschuk GD, 2007, CIRC RES, V101, P335, DOI 10.1161/CIRCRESAHA.107.150417
   Luyt CE, 2000, MOL MED, V6, P947, DOI 10.1007/BF03401829
   Maczewski M, 2008, CARDIOVASC RES, V79, P42, DOI 10.1093/cvr/cvn057
   Matter CM, 1999, CIRCULATION, V99, P2396, DOI 10.1161/01.CIR.99.18.2396
   Mellin V, 2005, EUR HEART J, V26, P1544, DOI 10.1093/eurheartj/ehi305
   Moritz F, 2004, FUND CLIN PHARMACOL, V18, P431, DOI 10.1111/j.1472-8206.2004.00255.x
   Mulder P, 2004, CIRCULATION, V109, P1674, DOI 10.1161/01.CIR.0000118464.48959.1C
   Mulder P, 1997, CIRCULATION, V96, P1976, DOI 10.1161/01.CIR.96.6.1976
   Mulder P, 2008, EUR HEART J, V29, P2171, DOI 10.1093/eurheartj/ehn277
   Pathak A, 2010, THERAPIE, V65, P483, DOI 10.2515/therapie/2010062
   Reil JC, 2013, EUR HEART J, V34, P2839, DOI 10.1093/eurheartj/ehs218
   Rösen P, 2006, HORM METAB RES, V38, P575, DOI 10.1055/s-2006-950397
   SAHN DJ, 1978, CIRCULATION, V58, P1072, DOI 10.1161/01.CIR.58.6.1072
   Serpillon S, 2009, AM J PHYSIOL-HEART C, V297, pH153, DOI 10.1152/ajpheart.01142.2008
   Silberman GA, 2010, CIRCULATION, V121, P519, DOI 10.1161/CIRCULATIONAHA.109.883777
   Siwik DA, 2001, AM J PHYSIOL-CELL PH, V280, pC53, DOI 10.1152/ajpcell.2001.280.1.C53
   Sola S, 2005, CIRCULATION, V111, P343, DOI 10.1161/01.CIR.0000153272.48711.B9
   Swedberg K, 2010, LANCET, V376, P875, DOI 10.1016/S0140-6736(10)61198-1
   Toblli JE, 2011, KIDNEY BLOOD PRESS R, V34, P20, DOI 10.1159/000320380
   Toblli JE, 2010, J HYPERTENS, V28, P1007, DOI 10.1097/HJH.0b013e328337598c
   Tsujino Takeshi, 2006, Am J Cardiovasc Drugs, V6, P219, DOI 10.2165/00129784-200606040-00002
   Ulu N, 2009, J CARDIOVASC PHARM, V53, P9, DOI 10.1097/FJC.0b013e318193dfce
   van Heerebeek L, 2008, CIRCULATION, V117, P43, DOI 10.1161/CIRCULATIONAHA.107.728550
   van Heerebeek L, 2009, CURR DIABETES REP, V9, P79, DOI 10.1007/s11892-009-0014-9
   Vercauteren M, 2006, CIRCULATION, V114, P2498, DOI 10.1161/CIRCULATIONAHA.106.630129
   Waller C, 2001, INT J CARDIAC IMAG, V17, P123, DOI 10.1023/A:1010603217785
   Zhao WY, 2008, MOL CELL BIOCHEM, V317, P43, DOI 10.1007/s11010-008-9803-8
   Zheng W, 2001, AM J PHYSIOL-HEART C, V280, pH909, DOI 10.1152/ajpheart.2001.280.2.H909
   Zhou XL, 2010, HYPERTENSION, V55, P880, DOI 10.1161/HYPERTENSIONAHA.109.145136
NR 61
TC 10
Z9 10
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0160-2446
EI 1533-4023
J9 J CARDIOVASC PHARM
JI J. Cardiovasc. Pharmacol.
PD OCT
PY 2015
VL 66
IS 4
BP 399
EP 408
DI 10.1097/FJC.0000000000000294
PG 10
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA CT5JL
UT WOS:000362845100011
PM 26222991
DA 2025-06-11
ER

PT J
AU El Hafidi, M
   Pérez, I
   Baños, G
AF El Hafidi, M
   Pérez, I
   Baños, G
TI Is glycine effective against elevated blood pressure?
SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
LA English
DT Article
DE glycine; hypertension; metabolic syndrome; oxidative stress
ID LOW-PROTEIN-DIET; NITRIC-OXIDE; IN-VIVO; METABOLIC RESPONSE;
   ENDOTHELIAL-CELLS; LIVER-INJURY; AMINO-ACIDS; HYPERTENSION; RAT;
   GLUTATHIONE
AB Purpose of review
   Glycine, a non-essential amino acid, has been found to protect against oxidative stress in several pathological situations, and it is required for the biosynthesis of structural proteins such as elastin. As hypertension is a disease in which free radicals and large vessel elasticity are involved, this article will examine the possible mechanisms by which glycine may protect against high blood pressure.
   Recent findings
   The addition of glycine to the diet reduces high blood pressure in a rat model of the metabolic syndrome. Also, glycine supplemented to the low protein diet of rat dams during pregnancy has a beneficial effect on blood pressure in their offspring. The mechanism by which glycine decreases high blood pressure can be attributed to its participation in the reduction of the generation of free radicals, increasing the availability of nitric oxide. In addition, as glycine is required for a number of critical metabolic pathways, such as the synthesis of the structural proteins collagen and elastin, the perturbation of these leads to impaired elastin formation in the aorta. This involves changes in the aorta's elastic properties, which would contribute to the development of hypertension.
   Summary
   The use of glycine to lower high blood pressure could have a significant clinical impact in patients with the metabolic syndrome and with limited resources, On the other hand, more studies are needed to explore the beneficial effect of glycine in other models of hypertension and to investigate possible side-effects of treatment with glycine.
C1 Inst Nacl Cardiol Ignacio Chavez, Dept Biochem, Mexico City 14080, DF, Mexico.
   Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Mexico City 14080, DF, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico
RP Inst Nacl Cardiol Ignacio Chavez, Dept Biochem, Juan Badiano 1, Mexico City 14080, DF, Mexico.
EM elhafidi@mail.ssa.gov.mx
RI El-Hafidi, Mohammed/AAN-4083-2021
CR André M, 2003, FEBS LETT, V546, P223, DOI 10.1016/S0014-5793(03)00576-3
   [Anonymous], TX MED
   ARNELLE DR, 1995, ARCH BIOCHEM BIOPHYS, V318, P279, DOI 10.1006/abbi.1995.1231
   BANOS G, 1995, TOXICOL LETT, V76, P1, DOI 10.1016/0378-4274(94)03180-0
   BERRY CL, 1978, BRIT HEART J, V40, P709
   Brawley L, 2004, J PHYSIOL-LONDON, V554, P497, DOI 10.1113/jphysiol.2003.052068
   COCHRANE WA, 1956, J CLIN INVEST, V35, P411, DOI 10.1172/JCI103292
   Cupid BC, 2004, CHEM RES TOXICOL, V17, P294, DOI 10.1021/tx0340706
   DAVDA RK, 1995, HYPERTENSION, V26, P764, DOI 10.1161/01.HYP.26.5.764
   DICKSON RC, 1992, GASTROENTEROLOGY, V102, P2098, DOI 10.1016/0016-5085(92)90338-Y
   El Hafidi M, 2004, AM J PHYSIOL-REG I, V287, pR1387, DOI 10.1152/ajpregu.00159.2004
   ElHafidi M, 1997, HYPERTENSION, V30, P624, DOI 10.1161/01.HYP.30.3.624
   Fang YZ, 2002, NUTRITION, V18, P872, DOI 10.1016/S0899-9007(02)00916-4
   Gannon MC, 2002, AM J CLIN NUTR, V76, P1302, DOI 10.1093/ajcn/76.6.1302
   Goldman R, 1997, ADV EXP MED BIOL, V400, P25
   GREENWALD SE, 2001, PEDIATR RES, V50, pA44
   GREKIN RJ, 1995, HYPERTENSION, V26, P193, DOI 10.1161/01.HYP.26.1.193
   GRIMBLE RF, 1992, J NUTR, V122, P2066, DOI 10.1093/jn/122.11.2066
   Jackson AA, 2002, CLIN SCI, V103, P633, DOI 10.1042/cs1030633
   Langley-Evans SC, 1999, LIFE SCI, V64, P965, DOI 10.1016/S0024-3205(99)00022-3
   Lees C, 1996, OBSTET GYNECOL, V88, P14, DOI 10.1016/0029-7844(96)00070-1
   Lei XG, 2002, METHOD ENZYMOL, V347, P213
   Lian C., 1915, Bull Acad Natl Med, V74, P525, DOI [DOI 10.53738/REVMED.2006.2.78.2041, 10.53738/REVMED.2006.2.78.2041]
   Mabrouk GM, 1998, BIOCHEM J, V330, P759
   Martyn CN, 1997, LANCET, V350, P953, DOI 10.1016/S0140-6736(96)10508-0
   Mauriz JL, 2001, FREE RADICAL BIO MED, V31, P1236, DOI 10.1016/S0891-5849(01)00716-X
   MING Y, 1998, J PHARMACOL EXP THER, V286, P1014
   Persaud C, 1996, J NUTR, V126, P2823
   Rose ML, 1999, CARCINOGENESIS, V20, P793, DOI 10.1093/carcin/20.5.793
   ROSSE RB, 1989, CLIN NEUROPHARMACOL, V12, P416, DOI 10.1097/00002826-198910000-00006
   Ruiz-Meana M, 2004, J PHYSIOL-LONDON, V558, P873, DOI 10.1113/jphysiol.2004.068320
   Sandoval GC, 1999, P W PHARMACOL SOC, V42, P31
   Schenck E. G., 1932, Archiv fur experimentelle Pathologie und Pharmakologie, V167, P201
   Senthilkumar R, 2003, POL J PHARMACOL, V55, P603
   TALMAN WT, 1989, BRAIN RES, V477, P7, DOI 10.1016/0006-8993(89)91388-7
   Touyz RM, 2004, HISTOCHEM CELL BIOL, V122, P339, DOI 10.1007/s00418-004-0696-7
   Wassertheil-Smoller S, 2000, ARCH INTERN MED, V160, P494, DOI 10.1001/archinte.160.4.494
   Weinberg JM, 1997, KIDNEY INT, V52, P140, DOI 10.1038/ki.1997.313
   WEINBERG JM, 1995, AM J PHYSIOL-RENAL, V268, pF110, DOI 10.1152/ajprenal.1995.268.1.F110
   WEINBERG JM, 1992, AM J PATHOL, V140, P457
   Wheeler M, 2000, FASEB J, V14, P476, DOI 10.1096/fasebj.14.3.476
   Wu GY, 2004, J NUTR, V134, P489, DOI 10.1093/jn/134.10.2783S
   Yamashina S, 2001, NUTR CANCER, V40, P197, DOI 10.1207/S15327914NC402_17
   Yin M, 2002, AM J PHYSIOL-RENAL, V282, pF417, DOI 10.1152/ajprenal.00011.2001
   ZHANG Y, 2002, HEPATOLOGY, V32, P542
   Zhong Z, 1999, MOL PHARMACOL, V56, P455, DOI 10.1124/mol.56.3.455
   Zhong Z, 2003, CURR OPIN CLIN NUTR, V6, P229, DOI 10.1097/00075197-200303000-00013
NR 47
TC 55
Z9 62
U1 1
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1363-1950
EI 1473-6519
J9 CURR OPIN CLIN NUTR
JI Curr. Opin. Clin. Nutr. Metab. Care
PD JAN
PY 2006
VL 9
IS 1
BP 26
EP 31
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 015KT
UT WOS:000235551000007
PM 16444815
DA 2025-06-11
ER

PT J
AU Diaz, A
   Muñoz-Arenas, G
   Venegas, B
   Vazquez-Roque, R
   Flores, G
   Guevara, J
   Gonzalez-Vergara, E
   Treviño, S
AF Diaz, Alfonso
   Munoz-Arenas, Guadalupe
   Venegas, Berenice
   Vazquez-Roque, Ruben
   Flores, Gonzalo
   Guevara, Jorge
   Gonzalez-Vergara, Enrique
   Trevino, Samuel
TI Metforminium Decavanadate (MetfDeca) Treatment Ameliorates Hippocampal
   Neurodegeneration and Recognition Memory in a Metabolic Syndrome Model
SO NEUROCHEMICAL RESEARCH
LA English
DT Article
DE Vanadium; Spines dendritic; Golgi-Cox; Interleukins; Reactive oxygen
   species; Inflammation
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; BISPEROXOVANDIUM
   PYRIDIN-2-SQUARAMIDE; ALZHEIMERS-DISEASE; VANADIUM COMPOUNDS;
   DIABETES-MELLITUS; TEMPORAL CORTEX; BRAIN; INFLAMMATION; MECHANISMS
AB The consumption of foods rich in carbohydrates, saturated fat, and sodium, accompanied by a sedentary routine, are factors that contribute to the progress of metabolic syndrome (MS). In this way, they cause the accumulation of body fat, hypertension, dyslipidemia, and hyperglycemia. Additionally, MS has been shown to cause oxidative stress, inflammation, and death of neurons in the hippocampus. Consequently, spatial and recognition memory is affected. It has recently been proposed that metformin decavanadate (MetfDeca) exerts insulin mimetic effects that enhance metabolism in MS animals; however, what effects it can cause on the hippocampal neurons of rats with MS are unknown. The objective of the work was to evaluate the effect of MetfDeca on hippocampal neurodegeneration and recognition memory in rats with MS. Administration of MetfDeca for 60 days in MS rats improved object recognition memory (NORt). In addition, MetfDeca reduced markers of oxidative stress and hippocampal neuroinflammation. Accompanied by an increase in the density and length of the dendritic spines of the hippocampus of rats with MS. We conclude that MetfDeca represents an important therapeutic agent to treat MS and induce neuronal and cognitive restoration mechanisms.
C1 [Diaz, Alfonso; Munoz-Arenas, Guadalupe; Trevino, Samuel] Benemerita Autonomous Univ Puebla, Fac Chem Sci, Puebla, Pue, Mexico.
   [Venegas, Berenice] Benemerita Autonomous Univ Puebla, Fac Biol Sci, Puebla, Pue, Mexico.
   [Vazquez-Roque, Ruben; Flores, Gonzalo] Benemerita Autonomous Univ Puebla, Inst Physiol, Lab Neuropsychiat, Puebla, Pue, Mexico.
   [Guevara, Jorge] Univ Nacl Autonoma Mexico, Fac Med, Dept Biochem, Mexico City, DF, Mexico.
   [Gonzalez-Vergara, Enrique] Benemerita Autonomous Univ Puebla, ICUAP, Chem Ctr, Puebla, Pue, Mexico.
C3 Benemerita Universidad Autonoma de Puebla; Benemerita Universidad
   Autonoma de Puebla; Benemerita Universidad Autonoma de Puebla;
   Universidad Nacional Autonoma de Mexico; Benemerita Universidad Autonoma
   de Puebla
RP Treviño, S (corresponding author), Benemerita Autonomous Univ Puebla, Fac Chem Sci, Puebla, Pue, Mexico.
EM samuel_trevino@hotmail.com
RI Vergara, Enrique/M-7641-2017; Vazquez Roque, Ruben/L-5757-2013; Flores,
   Gonzalo/B-1807-2014; Venegas, Berenice/AAG-4048-2021
OI Vazquez Roque, Ruben/0000-0002-2712-5714; VENEGAS MENESES,
   BERENICE/0000-0001-9009-655X; Flores, Gonzalo/0000-0002-4100-2104; Diaz,
   Alfonso/0000-0003-4092-6636
FU VIEPBUAP Grant [DIFA-NAT19-G, TEMS-NAT19-I]; PAPIIT-UNAM [IN214117]
FX Funding for this study was provided by grants from VIEPBUAP Grant (No.
   DIFA-NAT19-G) to DA and ST, (No. TEMS-NAT19-I) to TS and PAPIIT-UNAM
   (IN214117) to JG. None of the funding institutions had any further role
   in the study design, the collection of data, analyses, and
   interpretation of data, writing of the report or in the decision to
   submit the paper for publication and interpretation of data, writing of
   the report or the decision to submit the paper for publication.
CR Ahmadi-Eslamloo H, 2017, IRAN J MED SCI, V42, P544
   Antunes M, 2012, COGN PROCESS, V13, P93, DOI 10.1007/s10339-011-0430-z
   Assuncao N, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194990
   AURELIANO M, 1994, BIOCHEM BIOPH RES CO, V201, P155, DOI 10.1006/bbrc.1994.1682
   Balin BJ, 2014, CURR ALLERGY ASTHM R, V14, DOI 10.1007/s11882-013-0417-1
   Biessels GJ, 2018, BMC NEUROL, V18, DOI [10.1186/S12883-018-1014-7, 10.1186/s12883-018-1014-7]
   Biessels GJ, 2014, LANCET DIABETES ENDO, V2, P246, DOI 10.1016/S2213-8587(13)70088-3
   Cam MC, 2000, CAN J PHYSIOL PHARM, V78, P829, DOI 10.1139/cjpp-78-10-829
   Campbell Jared M, 2017, JBI Database System Rev Implement Rep, V15, P2055, DOI 10.11124/JBISRIR-2017-003380
   Chatterjee S, 2016, DIABETES CARE, V39, P300, DOI 10.2337/dc15-1588
   Cigliano L, 2018, MOL NEUROBIOL, V55, P2869, DOI 10.1007/s12035-017-0518-2
   Coudray C, 2016, BRIT J NUTR, V115, P1155, DOI 10.1017/S0007114515005528
   Diaz A, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8050113
   Diaz A, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/1358057
   Diaz A, 2012, J ALZHEIMERS DIS, V30, P505, DOI 10.3233/JAD-2012-111979
   Dolan DG, 2005, REGUL TOXICOL PHARM, V43, P1, DOI 10.1016/j.yrtph.2005.06.010
   Domingo JL, 2016, FOOD CHEM TOXICOL, V95, P137, DOI 10.1016/j.fct.2016.07.005
   Dong YQ, 2019, SCI CHINA LIFE SCI, V62, P126, DOI 10.1007/s11427-018-9350-1
   Dong YB, 2019, ENVIRON SCI POLLUT R, V26, P33004, DOI 10.1007/s11356-019-06381-7
   Arroyo-García LE, 2018, MOL NEUROBIOL, V55, P8625, DOI 10.1007/s12035-018-0991-2
   Flores G, 2005, NEUROSCIENCE, V133, P463, DOI 10.1016/j.neuroscience.2005.02.021
   Gallardo-Vera F, 2016, J IMMUNOTOXICOL, V13, P27, DOI 10.3109/1547691X.2014.996681
   García-García L, 2018, NEUROCHEM INT, V113, P92, DOI 10.1016/j.neuint.2017.11.018
   Gibon J, 2017, NEUROSCIENTIST, V23, P587, DOI 10.1177/1073858417697037
   Grillo CA, 2019, EXP NEUROL, V318, P71, DOI 10.1016/j.expneurol.2019.04.012
   Grillo CA, 2015, DIABETES, V64, P3927, DOI 10.2337/db15-0596
   Halpern A, 2010, DIABETOL METAB SYNDR, V2, DOI 10.1186/1758-5996-2-55
   Hamed SA, 2017, EXPERT REV CLIN PHAR, V10, P409, DOI 10.1080/17512433.2017.1293521
   He ZJ, 2020, FRONT MOL NEUROSCI, V13, DOI 10.3389/fnmol.2020.00021
   Heneka MT, 2017, BRAIN PATHOL, V27, P220, DOI 10.1111/bpa.12483
   Huang ML, 2014, BIOL TRACE ELEM RES, V157, P242, DOI 10.1007/s12011-013-9882-6
   Hurrle S, 2017, BIOMED J, V40, P257, DOI 10.1016/j.bj.2017.06.007
   Islam MK, 2007, BBA-GEN SUBJECTS, V1770, P1212, DOI 10.1016/j.bbagen.2007.05.003
   Kempuraj D., 2016, J NEUROL NEUROSURG S, V1
   KIESOW LA, 1972, CLIN CHIM ACTA, V41, P123, DOI 10.1016/0009-8981(72)90503-7
   Korbecki Jan, 2016, Postepy Biochem, V62, P60
   Leech T, 2019, PHARMACOL RES, V146, DOI 10.1016/j.phrs.2019.104261
   Li WJ, 2019, AGING DIS, V10, P949, DOI 10.14336/AD.2019.0120
   Liao XY, 2019, DRUG DES DEV THER, V13, P1957, DOI 10.2147/DDDT.S204956
   Moran C, 2019, CURR NEUROL NEUROSCI, V19, DOI 10.1007/s11910-019-0973-4
   Mucke L, 2009, NATURE, V461, P895, DOI 10.1038/461895a
   Munoz-Arenas G, 2020, SYNAPSE, V74, DOI 10.1002/syn.22153
   Pedditizi E, 2016, AGE AGEING, V45, P14, DOI 10.1093/ageing/afv151
   Petersen MC, 2018, PHYSIOL REV, V98, P2133, DOI 10.1152/physrev.00063.2017
   Pugazhenthi S, 2017, PROG MOL BIOL TRANSL, V146, P243, DOI 10.1016/bs.pmbts.2016.12.016
   Raffaitin C, 2009, DIABETES CARE, V32, P169, DOI 10.2337/dc08-0272
   Rehder D, 2016, FUTURE MED CHEM, V8, P325, DOI 10.4155/fmc.15.187
   Rice RA, 2017, GLIA, V65, P931, DOI 10.1002/glia.23135
   Roberts CK, 2013, COMPR PHYSIOL, V3, P1, DOI 10.1002/cphy.c110062
   Robins SJ, 2011, ARTERIOSCL THROM VAS, V31, P1208, DOI 10.1161/ATVBAHA.110.219055
   Rojas-Gutierrez E, 2017, SYNAPSE, V71, DOI 10.1002/syn.21990
   Rotermund C, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00400
   Rumora AE, 2018, FASEB J, V32, P195, DOI 10.1096/fj.201700206R
   Rumora L, 2001, NEUROCHEM INT, V39, P25, DOI 10.1016/S0197-0186(01)00004-3
   SHI XL, 1993, ARCH BIOCHEM BIOPHYS, V307, P336, DOI 10.1006/abbi.1993.1597
   Silva-Gómez AB, 2003, BRAIN RES, V983, P128, DOI 10.1016/S0006-8993(03)03042-7
   Spinelli M, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-02221-9
   Stapor Natalia, 2015, Pediatr Endocrinol Diabetes Metab, V20, P107, DOI 10.18544/PEDM-20.03.0010
   Stow JL, 2013, CYTOKINE GROWTH F R, V24, P227, DOI 10.1016/j.cytogfr.2013.04.001
   Sung KC, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-016-0368-7
   Thompson KH, 1999, BIOFACTORS, V10, P43, DOI 10.1002/biof.5520100105
   Toledo JB, 2017, ALZHEIMERS DEMENT, V13, P965, DOI 10.1016/j.jalz.2017.01.020
   Tomassoni D, 2013, NEUROSCI LETT, V543, P136, DOI 10.1016/j.neulet.2013.03.025
   Treviño S, 2020, J INORG BIOCHEM, V208, DOI 10.1016/j.jinorgbio.2020.111094
   Treviño S, 2019, BIOL TRACE ELEM RES, V188, P68, DOI 10.1007/s12011-018-1540-6
   Treviño S, 2018, BIOINORG CHEM APPL, V2018, DOI 10.1155/2018/2151079
   Treviño S, 2017, J CHEM NEUROANAT, V82, P65, DOI 10.1016/j.jchemneu.2017.02.007
   Treviño S, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/6058705
   Treviño S, 2015, SYNAPSE, V69, P421, DOI 10.1002/syn.21832
   Tripathi D, 2018, BIOL TRACE ELEM RES, V186, P52, DOI 10.1007/s12011-018-1289-y
   Tsave O, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/4013639
   Wahl D, 2018, CELL REP, V25, P2234, DOI 10.1016/j.celrep.2018.10.070
   Wang HH, 2020, PEDIATR GASTROENTERO, V23, P189
   Wang N, 2015, J INORG BIOCHEM, V152, P104, DOI 10.1016/j.jinorgbio.2015.07.012
   Williamson R, 2012, BIOCHEM PHARMACOL, V84, P737, DOI 10.1016/j.bcp.2012.05.007
   Yaffe K, 2007, CURR ALZHEIMER RES, V4, P123, DOI 10.2174/156720507780362191
   Yang Xiao-Gai, 2013, Prog Mol Subcell Biol, V54, P1, DOI 10.1007/978-3-642-41004-8_1
   Zelikoff JT, 2018, TOXICOL SCI, V162, P276, DOI 10.1093/toxsci/kfx257
   Zhang ZF, 2017, BRIT J PHARMACOL, V174, P641, DOI 10.1111/bph.13727
   Zhao FL, 2019, NEUROSCIENCE, V411, P237, DOI 10.1016/j.neuroscience.2019.05.033
   Ziablitsev S V, 2016, Fiziol Zh, V62, P18
NR 81
TC 12
Z9 12
U1 0
U2 9
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-3190
EI 1573-6903
J9 NEUROCHEM RES
JI Neurochem. Res.
PD MAY
PY 2021
VL 46
IS 5
BP 1151
EP 1165
DI 10.1007/s11064-021-03250-z
EA FEB 2021
PG 15
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA RO2IP
UT WOS:000616443800001
PM 33559829
DA 2025-06-11
ER

PT J
AU Lin, HY
   Lu, JH
   Lin, RJ
   Chueh, KS
   Juan, TJ
   Mao, JW
   Lee, YC
   Chuang, SM
   Shen, MC
   Sun, TW
   Juan, YS
AF Lin, Hung-Yu
   Lu, Jian-He
   Lin, Rong-Jyh
   Chueh, Kuang-Shun
   Juan, Tai-Jui
   Mao, Jing-Wen
   Lee, Yi-Chen
   Chuang, Shu-Mien
   Shen, Mei-Chen
   Sun, Ting-Wei
   Juan, Yung-Shun
TI Effects of Nitric Oxide on Bladder Detrusor Overactivity through the
   NRF2 and HIF-1α Pathways: A Rat Model Induced by Metabolic Syndrome and
   Ovarian Hormone Deficiency
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE nitric oxide; metabolic syndrome; ovarian hormone deficiency; overactive
   bladder; high-fat high-sugar diet
ID URINARY-TRACT SYMPTOMS; GREEN TEA CATECHINS; C-REACTIVE PROTEIN;
   L-ARGININE; OXIDATIVE STRESS; ISCHEMIA-REPERFUSION; SYNTHASE INHIBITION;
   INSULIN-RESISTANCE; L-NAME; RECEPTOR
AB Metabolic syndrome (MetS) includes cardiovascular risk factors like obesity, dyslipidemia, hypertension, and glucose intolerance, which increase the risk of overactive bladder (OAB), characterized by urgency, frequency, urge incontinence, and nocturia. Both MetS and ovarian hormone deficiency (OHD) are linked to bladder overactivity. Nitric oxide (NO) is known to reduce inflammation and promote healing but its effect on bladder overactivity in MetS and OHD is unclear. This study aimed to investigate NO's impact on detrusor muscle hyperactivity in rats with MetS and OHD. Female Sprague-Dawley rats were divided into seven groups based on diet and treatments involving L-arginine (NO precursor) and L-NAME (NOS inhibitor). After 12 months on a high-fat, high-sugar diet with or without OVX, a cystometrogram and tracing analysis of voiding behavior were used to identify the symptoms of detrusor hyperactivity. The MetS with or without OHD group had a worse bladder contractile response while L-arginine ameliorated bladder contractile function. In summary, MetS with or without OHD decreased NO production, reduced angiogenesis, and enhanced oxidative stress to cause bladder overactivity, mediated through the NF-kB signaling pathway, whereas L-arginine ameliorated the symptoms of detrusor overactivity and lessened oxidative damage via the NRF2/HIF-1 alpha signaling pathway in MetS with or without OHD-induced OAB.
C1 [Lin, Hung-Yu] I Shou Univ, Sch Med, Kaohsiung 84001, Taiwan.
   [Lin, Hung-Yu] I Shou Univ, E Da Canc Hosp, Dept Surg, Div Urol, Kaohsiung 840301, Taiwan.
   [Lin, Hung-Yu] I Shou Univ, E Da Hosp, Dept Obstet & Gynecol, Kaohsiung 82445, Taiwan.
   [Lu, Jian-He] Natl Pingtung Univ Sci & Technol, Gen Res Serv Ctr, Pingtung Cty 912301, Taiwan.
   [Lin, Rong-Jyh] Kaohsiung Med Univ, Coll Med, Sch Med, Dept Parasitol, Kaohsiung 807378, Taiwan.
   [Chueh, Kuang-Shun; Juan, Yung-Shun] Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung 807378, Taiwan.
   [Chueh, Kuang-Shun] Kaohsiung Municipal Tatung Hosp, Dept Urol, Kaohsiung 80661, Taiwan.
   [Chueh, Kuang-Shun; Mao, Jing-Wen; Chuang, Shu-Mien; Shen, Mei-Chen; Sun, Ting-Wei; Juan, Yung-Shun] Kaohsiung Med Univ Hosp, Dept Urol, Kaohsiung 80756, Taiwan.
   [Juan, Tai-Jui] Kaohsiung Armed Forces Gen Hosp, Kaohsiung 802301, Taiwan.
   [Juan, Tai-Jui] Kaohsiung Vet Gen Hosp, Dept Surg, Div Neurosurg, Kaohsiung 813414, Taiwan.
   [Lee, Yi-Chen] Kaohsiung Med Univ, Coll Med, Sch Med, Dept Anat, Kaohsiung 807378, Taiwan.
   [Chuang, Shu-Mien; Shen, Mei-Chen; Sun, Ting-Wei; Juan, Yung-Shun] Kaohsiung Med Univ, Coll Med, Dept Urol, Kaohsiung 807378, Taiwan.
C3 I Shou University; E-Da Hospital; I Shou University; I Shou University;
   E-Da Hospital; National Pingtung University Science & Technology;
   Kaohsiung Medical University; Kaohsiung Medical University; Kaohsiung
   Medical University; Kaohsiung Municipal Ta-Tung Hospital; Kaohsiung
   Medical University; Kaohsiung Medical University Hospital; Kaohsiung
   Veterans General Hospital; Kaohsiung Medical University; Kaohsiung
   Medical University
RP Juan, YS (corresponding author), Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung 807378, Taiwan.; Juan, YS (corresponding author), Kaohsiung Med Univ Hosp, Dept Urol, Kaohsiung 80756, Taiwan.; Juan, YS (corresponding author), Kaohsiung Med Univ, Coll Med, Dept Urol, Kaohsiung 807378, Taiwan.
EM ed100464@edah.org.tw; toddherpuma@mail.npust.edu.tw; rjlin@kmu.edu.tw;
   spacejason69@yahoo.com.tw; erryjuan@gmail.com; blast2337@gmail.com;
   yichen83@kmu.edu.tw; u9181002@gmail.com; bear5824@gmail.com;
   ting.wei0220@gmail.com; 840066@kmu.edu.tw
RI Lin, Rong-Jyh/D-5036-2009; 闕, 光瞬/KQU-3018-2024
FU Ministry of Science and Technology; NSTC [113-2221-E-020-007, MOST
   111-2221-E-020-004]; Department of Medical Research, Kaohsiung Medical
   University Hospital [KMUH-110-0M55, KMUH-111-1R53, KMUH-112-2R58,
   KMTTH-110-030, KMTTH-111-R010];  [NSTC112-2314-B-037-118]; 
   [MOST111-2314-B-037-066];  [MOST111-2314-B-037-072]
FX This research is supported by the grants from the Ministry of Science
   and Technology NSTC112-2314-B-037-118 (Yung-Shun Juan),
   MOST111-2314-B-037-066 (Yung-Shun Juan), MOST111-2314-B-037-072
   (Kuang-Shun Chueh), NSTC 113-2221-E-020-007 (Jian-He Lu), MOST
   111-2221-E-020-004 (Jian-He Lu), and in part by the Department of
   Medical Research, Kaohsiung Medical University Hospital (KMUH-110-0M55;
   KMUH-111-1R53; KMUH-112-2R58 (Yung-Shun Juan) and KMTTH-110-030;
   KMTTH-111-R010 (Kuang-Shun Chueh)).
CR Aikawa K, 2005, UROL INT, V75, P133, DOI 10.1159/000087167
   Aikawa K, 2003, J UROLOGY, V170, P634, DOI 10.1097/01.ju.0000068723.05004.ca
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Alexandre EC, 2016, EUR J PHARMACOL, V788, P29, DOI 10.1016/j.ejphar.2016.06.017
   Apostolidis A, 2005, UROLOGY, V65, P400, DOI 10.1016/j.urology.2004.10.007
   Azadzoi KM, 2011, J UROLOGY, V186, P2115, DOI 10.1016/j.juro.2011.06.047
   Azadzoi KM, 2003, J UROLOGY, V169, P1885, DOI 10.1097/01.ju.0000048668.97821.f4
   Barnard RJ, 1998, J APPL PHYSIOL, V84, P1311, DOI 10.1152/jappl.1998.84.4.1311
   Bennett HL, 2003, AUTON NEUROSCI-BASIC, V105, P90, DOI 10.1016/S1566-0702(03)00044-4
   Birder LA, 2007, NAT CLIN PRACT UROL, V4, P46, DOI 10.1038/ncpuro0672
   Brand JS, 2011, INT J EPIDEMIOL, V40, P189, DOI 10.1093/ije/dyq158
   BRINDLEY DN, 1995, INT J OBESITY, V19, pS69
   BURNETT AL, 1995, UROLOGY, V45, P1071, DOI 10.1016/S0090-4295(99)80136-8
   Cannon TW, 2001, LIFE SCI, V69, P1193
   Cardozo L, 2004, ACTA OBSTET GYN SCAN, V83, P892, DOI 10.1111/j.0001-6349.2004.00581.x
   Chambers JC, 2001, CIRCULATION, V104, P145, DOI 10.1161/01.CIR.104.2.145
   Chang JW, 2024, UROL SCI, V35, P19, DOI 10.1097/us9.0000000000000014
   Cheng CL, 2014, AM J PHYSIOL-RENAL, V306, pF181, DOI 10.1152/ajprenal.00298.2013
   Chung SD, 2013, EUR J NUTR, V52, P347, DOI 10.1007/s00394-012-0342-4
   Conners W, 2006, AM J PHYSIOL-RENAL, V290, pF357, DOI 10.1152/ajprenal.00261.2005
   Eshtiaghi R, 2010, MATURITAS, V65, P262, DOI 10.1016/j.maturitas.2009.11.004
   Esposito K, 2003, JAMA-J AM MED ASSOC, V289, P1799, DOI 10.1001/jama.289.14.1799
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   Förstermann U, 2012, EUR HEART J, V33, P829, DOI 10.1093/eurheartj/ehr304
   FORSTERMANN U, 1994, HYPERTENSION, V23, P1121, DOI 10.1161/01.HYP.23.6.1121
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   He Q, 2016, PROSTATE CANCER P D, V19, P7, DOI 10.1038/pcan.2015.43
   Heinonen I, 2017, EUR J APPL PHYSIOL, V117, P1175, DOI 10.1007/s00421-017-3604-2
   Ho MH, 2004, CURR OPIN OBSTET GYN, V16, P423, DOI 10.1097/00001703-200410000-00012
   Imamov O, 2007, P NATL ACAD SCI USA, V104, P9806, DOI 10.1073/pnas.0703410104
   Iwata Atsushi, 2006, J Cardiol, V47, P1
   Juan YS, 2012, BJU INT, V110, pE236, DOI 10.1111/j.1464-410X.2012.11258.x
   Juan YS, 2012, MENOPAUSE, V19, P346, DOI 10.1097/gme.0b013e31822d652d
   Kone BC, 2003, AM J PHYSIOL-RENAL, V285, pF178, DOI 10.1152/ajprenal.00048.2003
   LaMonte MJ, 2002, CIRCULATION, V106, P403, DOI 10.1161/01.CIR.0000025425.20606.69
   Lee WC, 2011, J UROLOGY, V186, P318, DOI 10.1016/j.juro.2011.03.037
   Lee YL, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-23800-w
   Leiria LO, 2014, J UROLOGY, V191, P539, DOI 10.1016/j.juro.2013.09.020
   Li Q, 2016, J CLIN NEUROSCI, V34, P264, DOI 10.1016/j.jocn.2016.09.028
   Liang W, 2002, LIFE SCI, V71, P351, DOI 10.1016/S0024-3205(02)01645-4
   Lin WY, 2007, AM J PHYSIOL-REG I, V293, pR2390, DOI 10.1152/ajpregu.00508.2007
   Losordo DW, 2001, ARTERIOSCL THROM VAS, V21, P6, DOI 10.1161/01.ATV.21.1.6
   Miller A, 2008, CURR OPIN GASTROEN, V24, P204, DOI 10.1097/MOG.0b013e3282f3f4c4
   Misitzis Angelica, 2019, Int J Womens Dermatol, V5, P205, DOI 10.1016/j.ijwd.2019.06.030
   Mondal S, 2024, UROL SCI, V35, P90, DOI 10.1097/us9.0000000000000013
   Monti LD, 2008, EUR J CLIN INVEST, V38, P849, DOI 10.1111/j.1365-2362.2008.02027.x
   Morrissey JJ, 1996, J AM SOC NEPHROL, V7, P2202
   Munoz A, 2011, NEUROCHEM INT, V58, P295, DOI 10.1016/j.neuint.2010.12.002
   Naderali EK, 2004, ATHEROSCLEROSIS, V172, P63, DOI 10.1016/j.atherosclerosis.2003.09.021
   Nakanishi Katsuhiko, 1992, American Journal of Physiology, V263, pH1650
   Nawrocki AR, 2004, CURR OPIN PHARMACOL, V4, P281, DOI 10.1016/j.coph.2004.03.003
   Nomiya M, 2015, INT J UROL, V22, P40, DOI 10.1111/iju.12652
   Nonami Y, 1997, SURG TODAY, V27, P583, DOI 10.1007/BF02388212
   Papka RE, 2003, INT REV CYTOL, V231, P91, DOI 10.1016/S0074-7696(03)31003-4
   Peyronnet B, 2019, EUR UROL, V75, P988, DOI 10.1016/j.eururo.2019.02.038
   Roberts CK, 2000, HYPERTENSION, V36, P423, DOI 10.1161/01.HYP.36.3.423
   Robinson D, 2003, UROLOGY, V62, P45, DOI 10.1016/S0090-4295(03)00676-9
   Rohrmann S, 2005, INT J OBESITY, V29, P310, DOI 10.1038/sj.ijo.0802881
   Saito M, 1999, J UROLOGY, V162, P1490, DOI 10.1016/S0022-5347(05)68346-2
   Saito M, 2002, NEUROUROL URODYNAM, V21, P566, DOI 10.1002/nau.10012
   Saito M, 1998, LIFE SCI, V62, pPL149, DOI 10.1016/S0024-3205(98)00026-5
   Saitongdee P, 1999, ENDOTHELIUM-J ENDOTH, V6, P197, DOI 10.3109/10623329909053410
   Stefanska A, 2015, ADV CLIN CHEM, V72, P1, DOI 10.1016/bs.acc.2015.07.001
   Stenberg A, 1995, MATURITAS, V22, pS17, DOI 10.1016/0378-5122(95)00958-2
   Stokes KY, 2009, AM J PHYSIOL-HEART C, V296, pH1281, DOI 10.1152/ajpheart.01291.2008
   Sun Y, 2004, J UROLOGY, V171, P448, DOI 10.1097/01.ju.0000099660.46774.3c
   Tengan CH, 2012, INT J MOL SCI, V13, P17160, DOI 10.3390/ijms131217160
   Tong YC, 2007, J UROLOGY, V178, P1537, DOI 10.1016/j.juro.2007.05.114
   Torréns JI, 2009, MENOPAUSE, V16, P257, DOI 10.1097/gme.0b013e318185e249
   Tsai TN, 2014, ACTA CARDIOL SIN, V30, P215
   Varejckova M, 2017, LIFE SCI, V175, P52, DOI 10.1016/j.lfs.2017.03.014
   Vincent Michelle A, 2003, Curr Diab Rep, V3, P279, DOI 10.1007/s11892-003-0018-9
   Wang QD, 1997, J CARDIOVASC PHARM, V29, P291, DOI 10.1097/00005344-199702000-00020
   Wein AJ, 2002, UROLOGY, V60, P7, DOI 10.1016/S0090-4295(02)01784-3
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Whitbeck C, 2007, UROL INT, V78, P30, DOI 10.1159/000096931
   Wu MT, 2012, J CLIN LAB ANAL, V26, P82, DOI 10.1002/jcla.21487
   Wu YH, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22116014
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Xu SH, 2008, ENDOCRINOLOGY, V149, P5540, DOI 10.1210/en.2008-0278
   Yokoyama T, 2004, J UROLOGY, V172, P596, DOI 10.1097/01.ju.0000132769.71014.b5
   Yoshimura N, 2008, N-S ARCH PHARMACOL, V377, P437, DOI 10.1007/s00210-007-0209-z
   Yu HJ, 2006, UROL INT, V77, P327, DOI 10.1159/000096337
NR 84
TC 2
Z9 2
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2024
VL 25
IS 20
AR 11103
DI 10.3390/ijms252011103
PG 33
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA K1C6F
UT WOS:001341335300001
PM 39456884
OA gold
DA 2025-06-11
ER

PT J
AU Demirtas, CY
   Bircan, FS
   Pasaoglu, OT
   Turkozkan, N
AF Demirtas, Yilmaz C.
   Bircan, F. S.
   Pasaoglu, O. T.
   Turkozkan, N.
TI The effects of resveratrol on hepatic oxidative stress in metabolic
   syndrome model induced by high fructose diet
SO BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
LA English
DT Article
DE resveratrol; metabolic syndrome; fructose; oxidative stress; liver
ID CARDIOVASCULAR-DISEASES; POTENTIAL ROLE; POLYPHENOLS; LIVER; EXPRESSION;
   OXIDANT; OBESITY; KIDNEY; RATS
AB BACKGROUND: The purpose of this study was to evaluate probable protective effects of resveratrol treatment on hepatic oxidative events in a rat model of metabolic syndrome (MetS).
   METHODS: Thirty-two male adult rats were randomly divided into 4 groups: control, fructose, resveratrol, and fructose plus resveratrol. To induce MetS, fructose solution (20 % in drinking water) was used. Resveratrol (10 mg/kg/day) was given by oral gavage. All treatments were given for 8 weeks. Serum lipid profile, glucose and insulin levels, liver total oxidant status (TOS) levels and paraoxonase (PON), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) activities were analyzed.
   RESULTS: Fructose-fed rats displayed statistically significant increases in TOS levels, and decreases in PON activity compared to the control group. Resveratrol treatment moderately prevented the decrease in liver PON activity caused by fructose. On the other hand, resveratrol, alone or in combination with fructose, did not change the TOS levels when compared to the fructose group. The SOD and CAT activities in all groups did not change.
   CONCLUSION: In this experimental design, high-fructose consumption led to elevated TOS levels and low PON activities. The resveratrol therapy shown beneficial effects on PON activity. However, it was found to behave like a prooxidant when administered together with fructose and alone in some parameters. Our results can inspire the development of new clinical therapy in patients with MetS (Tab. 2, Ref. 34).
C1 [Demirtas, Yilmaz C.; Bircan, F. S.; Pasaoglu, O. T.; Turkozkan, N.] Gazi Univ, Dept Biochem, Fac Med, Ankara, Turkey.
   [Bircan, F. S.] Gazi Univ, Dept Biol, Fac Sci, TR-06500 Ankara, Turkey.
   [Pasaoglu, O. T.] Gazi Univ, Fac Hlth Sci, Ankara, Turkey.
C3 Gazi University; Gazi University; Gazi University
RP Bircan, FS (corresponding author), Gazi Univ, Dept Biol, Fac Sci, TR-06500 Ankara, Turkey.
EM fsbircan@yahoo.com
RI Yılmaz, Canan/AAT-7788-2020; Pasaoglu, Ozge/AAZ-5223-2020
OI Bircan, Filiz Sezen/0000-0002-1007-2484; YILMAZ,
   CANAN/0000-0002-6799-6522
FU Gazi University, Department of Scientific Research Projects Unit
   [01/2010-17]
FX This study was supported by Gazi University, Department of Scientific
   Research Projects Unit (Project Number: 01/2010-17).
CR Ackerman Z, 2010, BASIC CLIN PHARMACOL, V107, P663, DOI 10.1111/j.1742-7843.2010.00553.x
   Aebi H, 1974, METHODS ENZYM ANAL, V2nd, P673, DOI [10.1016/B978-0-12-091302-2.50032-3, DOI 10.1016/B978-0-12-091302-2.50032-3]
   Ahn J, 2008, J HEPATOL, V49, P1019, DOI 10.1016/j.jhep.2008.08.012
   Bagul PK, 2012, PHARMACOL RES, V66, P260, DOI 10.1016/j.phrs.2012.05.003
   Borriello A, 2010, NUTR METAB CARDIOVAS, V20, P618, DOI 10.1016/j.numecd.2010.07.004
   Brown L, 2009, ALCOHOL CLIN EXP RES, V33, P1513, DOI 10.1111/j.1530-0277.2009.00989.x
   Cai YJ, 2003, BBA-MOL BASIS DIS, V1637, P31, DOI 10.1016/S0925-4439(02)00174-6
   Chen CK, 1996, GEN PHARMACOL-VASC S, V27, P363
   Costa LG, 2011, BIOCHEM PHARMACOL, V81, P337, DOI 10.1016/j.bcp.2010.11.008
   de Moura RF, 2009, BRIT J NUTR, V101, P1178, DOI 10.1017/S0007114508066774
   Donnelly LE, 2001, AM J PHYSIOL, V287, pL774
   Elnakish MT, 2013, J PATHOL, V231, P290, DOI 10.1002/path.4255
   Erel O, 2005, CLIN BIOCHEM, V38, P1103, DOI 10.1016/j.clinbiochem.2005.08.008
   Fujimoto A, 2009, BASIC CLIN PHARMACOL, V104, P455, DOI 10.1111/j.1742-7843.2009.00386.x
   Fülöp P, 2016, CHEM-BIOL INTERACT, V259, P388, DOI 10.1016/j.cbi.2016.04.003
   Gregório BM, 2016, CURR PHARM DESIGN, V22, P859, DOI 10.2174/1381612822666151209152352
   Hasan MM, 2017, MOLECULES, V22, DOI 10.3390/molecules22020294
   Hassan-Khabbar S, 2008, LIVER TRANSPLANT, V14, P451, DOI 10.1002/lt.21405
   Hopps E, 2010, NUTR METAB CARDIOVAS, V20, P72, DOI 10.1016/j.numecd.2009.06.002
   Ilhan N, 2014, TURK J BIOCHEM, V39, P449, DOI 10.5505/tjb.2014.58569
   Johnson RJ, 2007, AM J CLIN NUTR, V86, P899
   Khitan Z, 2013, J NUTR METAB, V2013, DOI 10.1155/2013/682673
   Kulka M, 2016, POL J VET SCI, V19, P225, DOI 10.1515/pjvs-2016-0028
   Maithili Karpaga Selvi Nachimuthu, 2015, Sci Pharm, V83, P159, DOI 10.3797/scipharm.1408-16
   Miatello R, 2005, AM J HYPERTENS, V18, P864, DOI 10.1016/j.amjhyper.2004.12.012
   Pandey KB, 2011, ARAB J CHEM, V4, P293, DOI 10.1016/j.arabjc.2010.06.049
   Schmatz R, 2012, BIOCHIMIE, V94, P374, DOI 10.1016/j.biochi.2011.08.005
   Soleas GJ, 1997, CLIN BIOCHEM, V30, P91, DOI 10.1016/S0009-9120(96)00155-5
   Sripradha Ramalingam, 2016, Journal of Basic and Clinical Physiology and Pharmacology, V27, P349, DOI 10.1515/jbcpp-2014-0132
   SUN Y, 1988, CLIN CHEM, V34, P497
   Szkudelski T, 2015, BBA-MOL BASIS DIS, V1852, P1145, DOI 10.1016/j.bbadis.2014.10.013
   Takahashi S, 2009, BIOL PHARM BULL, V32, P1840, DOI 10.1248/bpb.32.1840
   Zhang DM, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040335
   Zhu W, 2014, NUTR METAB, V11, DOI 10.1186/1743-7075-11-35
NR 34
TC 20
Z9 22
U1 1
U2 8
PU AEPRESS SRO
PI BRATISLAVA
PA BAJZOVA 7, BRATISLAVA, 821 08, SLOVAKIA
SN 0006-9248
EI 1336-0345
J9 BRATISL MED J
JI Bratisl. Med. J.
PY 2018
VL 119
IS 1
BP 36
EP 40
DI 10.4149/BLL_2018_008
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FW3BZ
UT WOS:000425181900008
PM 29405729
OA gold
DA 2025-06-11
ER

PT J
AU Nagase, M
   Yoshida, S
   Shibata, S
   Nagase, T
   Gotoda, T
   Ando, K
   Fujita, T
AF Nagase, Miki
   Yoshida, Shigetaka
   Shibata, Shigeru
   Nagase, Takashi
   Gotoda, Takanari
   Ando, Katsuyuki
   Fujita, Toshiro
TI Enhanced aldosterone signaling in the early nephropathy of rats with
   metabolic syndrome: Possible contribution of fat-derived factors
SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
LA English
DT Article
ID CHRONIC KIDNEY-DISEASE; PREVENTS DIABETIC-NEPHROPATHY; HYPERTENSIVE
   KOLETSKY RAT; MINERALOCORTICOID RECEPTOR; GLOMERULAR HYPERFILTRATION;
   PODOCYTE INJURY; PROTEIN-KINASE; BLOOD-PRESSURE; RENAL INJURY; MODEL
AB Metabolic syndrome is an important risk factor for proteinuria and chronic kidney disease independent of diabetes and hypertension; however, the underlying mechanisms have not been elucidated. Aldosterone is implicated in target organ injury of obesity-related disorders. This study investigated the role of aldosterone in the early nephropathy of 17-wk-old SHR/NDmcr-cp, a rat model of metabolic syndrome. Proteinuria was prominent in SHR/NDmcr-cp compared with nonobese SHR, which was accompanied by podocyte injury as evidenced by foot process effacement, induction of desmin and attenuation of nephrin. Serum aldosterone level, renal and glomerular expressions of aldosterone effector kinase Sgk1, and oxidative stress markers all were elevated in SHR/NDmcr-cp. Mineralocorticoid receptors were expressed in glomerular podocytes. Eplerenone, a selective aldosterone blocker, effectively improved podocyte damage, proteinuria, Sgk1, and oxidant stress. An antioxidant tempol also alleviated podocyte impairment and proteinuria, along with inhibition of Sgk1. As for the mechanisms of aldosterone excess, visceral adipocytes that were isolated from SHR/NDmcr-cp secreted substances that stimulate aldosterone production in adrenocortical cells. The aldosterone-releasing activity of adipocytes was not inhibited by candesartan. Adipocytes from nonobese SHR did not show such activity. In conclusion, SHR/NDmcr-cp exhibit enhanced aldosterone signaling, podocyte injury, and proteinuria, which are ameliorated by eplerenone or tempol. The data also suggest that adipocyte-derived factors other than angiotensin II might contribute to the aldosterone excess of this model.
C1 Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Bunkyo Ku, Tokyo 1138655, Japan.
   Univ Tokyo, Grad Sch Med, Dept Clin & Mol Epidemiol, 22 Century Med & Res Ctr, Tokyo 1138655, Japan.
   Murayama Med Ctr, Natl Hosp Org, Clin Res Ctr, Tokyo, Japan.
C3 University of Tokyo; University of Tokyo
RP Nagase, M (corresponding author), Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM mnagase-tky@umin.ac.jp
OI Fujita, Toshiro/0000-0001-9141-7060; Shibata,
   Shigeru/0000-0002-6868-0626
CR Aldigier JC, 2005, J AM SOC NEPHROL, V16, P3306, DOI 10.1681/asn.2004090804
   Bhargava A, 2001, ENDOCRINOLOGY, V142, P1587, DOI 10.1210/en.142.4.1587
   Bochud M, 2006, HYPERTENSION, V48, P239, DOI 10.1161/01.HYP.0000231338.41548.fc
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   de Paula RB, 2004, HYPERTENSION, V43, P41, DOI 10.1161/01.HYP.0000105624.68174.00
   EGAN BM, 1994, AM J HYPERTENS, V7, P886, DOI 10.1093/ajh/7.10.886
   Ehrhart-Bornstein M, 2003, P NATL ACAD SCI USA, V100, P14211, DOI 10.1073/pnas.2336140100
   Engeli S, 2005, HYPERTENSION, V45, P356, DOI 10.1161/01.HYP.0000154361.47683.d3
   Ernsberger P, 1999, ANN NY ACAD SCI, V892, P272, DOI 10.1111/j.1749-6632.1999.tb07801.x
   Farjah M, 2003, HYPERTENSION, V41, P874, DOI 10.1161/01.HYP.0000063885.48344.EA
   Fujisawa G, 2004, KIDNEY INT, V66, P1493, DOI 10.1111/j.1523-1755.2004.00913.x
   Fuller PJ, 2005, HYPERTENSION, V46, P1227, DOI 10.1161/01.HYP.0000193502.77417.17
   Go AS, 2004, NEW ENGL J MED, V351, P1296, DOI 10.1056/NEJMoa041031
   Gomez-Sanchez CE, 2006, ENDOCRINOLOGY, V147, P1343, DOI 10.1210/en.2005-0860
   Goodfriend TL, 2004, HYPERTENSION, V43, P358, DOI 10.1161/01.HYP.0000113294.06704.64
   Greene EL, 1996, J CLIN INVEST, V98, P1063, DOI 10.1172/JCI118867
   Gross ML, 2004, LAB INVEST, V84, P452, DOI 10.1038/labinvest.3700052
   Han SY, 2006, J AM SOC NEPHROL, V17, P1362, DOI 10.1681/ASN.2005111196
   Hostetter TH, 2003, J AM SOC NEPHROL, V14, P2395, DOI 10.1097/01.ASN.0000086472.65806.73
   Hou JH, 2002, J AM SOC NEPHROL, V13, P1190, DOI 10.1097/01.ASN.0000013702.73570.3B
   Ito T, 2000, NEUROSCI RES, V37, P173, DOI 10.1016/S0168-0102(00)00112-7
   Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2548, DOI 10.1210/jc.2004-0395
   KRETZLER M, 1994, VIRCHOWS ARCH, V425, P181
   Kumar JM, 1999, J AM SOC NEPHROL, V10, P2488
   Kurella M, 2005, J AM SOC NEPHROL, V16, P2134, DOI 10.1681/ASN.2005010106
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lang F, 2000, P NATL ACAD SCI USA, V97, P8157, DOI 10.1073/pnas.97.14.8157
   Leong MLL, 2003, J BIOL CHEM, V278, P5871, DOI 10.1074/jbc.M211649200
   Nagase M, 2006, HYPERTENSION, V47, P1084, DOI 10.1161/01.HYP.0000222003.28517.99
   Nagase T, 2005, J CRANIOFAC SURG, V16, P80, DOI 10.1097/00001665-200501000-00016
   Nangaku M, 2005, NEPHROL DIAL TRANSPL, V20, P2661, DOI 10.1093/ndt/gfi096
   Nishiyama A, 2005, HYPERTENSION, V45, P710, DOI 10.1161/01.HYP.0000154681.38944.9a
   Nishiyama A, 2004, HYPERTENSION, V43, P841, DOI 10.1161/01.HYP.0000118519.66430.22
   Pagtalunan ME, 1997, J CLIN INVEST, V99, P342, DOI 10.1172/JCI119163
   Pavenstädt H, 2003, PHYSIOL REV, V83, P253, DOI 10.1152/physrev.00020.2002
   Quinkler M, 2005, CIRCULATION, V112, P1435, DOI 10.1161/CIRCULATIONAHA.105.539122
   Rajagopalan S, 2002, CIRCULATION, V105, P2212, DOI 10.1161/01.CIR.0000015854.60710.10
   Remuzzi G, 1998, NEW ENGL J MED, V339, P1448, DOI 10.1056/NEJM199811123392007
   Ribstein J, 2005, J AM SOC NEPHROL, V16, P1320, DOI 10.1681/ASN.2004100878
   Rossi GP, 2006, HYPERTENSION, V48, P232, DOI 10.1161/01.HYP.0000230444.01215.6a
   Sato A, 2003, HYPERTENSION, V41, P64, DOI 10.1161/01.HYP.0000044937.95080.E9
   Shibata S, 2006, J AM SOC NEPHROL, V17, P754, DOI 10.1681/ASN.2005050571
   Takaya K, 1996, NAT GENET, V14, P130, DOI 10.1038/ng1096-130
   TUCK ML, 1981, NEW ENGL J MED, V304, P930, DOI 10.1056/NEJM198104163041602
   Vallon V, 2005, AM J PHYSIOL-REG I, V289, pR395, DOI 10.1152/ajpregu.00731.2004
   Vallon V, 2005, CURR OPIN NEPHROL HY, V14, P59, DOI 10.1097/00041552-200501000-00010
   Ward MR, 2001, CIRCULATION, V104, P467, DOI 10.1161/hc3001.091458
   Zhang RB, 2005, AM J MED SCI, V330, P319, DOI 10.1097/00000441-200512000-00010
NR 48
TC 218
Z9 226
U1 0
U2 9
PU AMERICAN SOCIETY NEPHROLOGY
PI WASHINGTON
PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA
SN 1046-6673
J9 J AM SOC NEPHROL
JI J. Am. Soc. Nephrol.
PD DEC
PY 2006
VL 17
IS 12
BP 3438
EP 3446
DI 10.1681/ASN.2006080944
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 111WD
UT WOS:000242485400021
PM 17082236
OA Bronze
DA 2025-06-11
ER

PT J
AU Carrer, M
   Liu, N
   Grueter, CE
   Williams, AH
   Frisard, MI
   Hulver, MW
   Bassel-Duby, R
   Olson, EN
AF Carrer, Michele
   Liu, Ning
   Grueter, Chad E.
   Williams, Andrew H.
   Frisard, Madlyn I.
   Hulver, Matthew W.
   Bassel-Duby, Rhonda
   Olson, Eric N.
TI Control of mitochondrial metabolism and systemic energy homeostasis by
   microRNAs 378 and 378<SUP>☆</SUP>
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE fatty acid oxidation; adipocytes; mitochondrial CO2 production
ID FATTY-ACID-METABOLISM; INSULIN-RESISTANCE; SKELETAL-MUSCLE;
   TRANSCRIPTIONAL REGULATION; OXIDATIVE STRESS; GENE-EXPRESSION;
   DYSFUNCTION; OBESITY; GAMMA; DISEASE
AB Obesity and metabolic syndrome are associated with mitochondrial dysfunction and deranged regulation of metabolic genes. Peroxisome proliferator-activated receptor gamma coactivator 1 beta (PGC-1 beta) is a transcriptional coactivator that regulates metabolism and mitochondrial biogenesis through stimulation of nuclear hormone receptors and other transcription factors. We report that the PGC-1 beta gene encodes two microRNAs (miRNAs), miR-378 and miR-378(star), which counterbalance the metabolic actions of PGC-1 beta. Mice genetically lacking miR-378 and miR-378(star) are resistant to high-fat diet-induced obesity and exhibit enhanced mitochondrial fatty acid metabolism and elevated oxidative capacity of insulin-target tissues. Among the many targets of these miRNAs, carnitine O-acetyltransferase, a mitochondrial enzyme involved in fatty acid metabolism, and MED13, a component of the Mediator complex that controls nuclear hormone receptor activity, are repressed by miR-378 and miR-378(star), respectively, and are elevated in the livers of miR-378/378(star) KO mice. Consistent with these targets as contributors to the metabolic actions of miR-378 and miR-378(star), previous studies have implicated carnitine O-acetyltransferase and MED13 in metabolic syndrome and obesity. Our findings identify miR-378 and miR-378(star) as integral components of a regulatory circuit that functions under conditions of metabolic stress to control systemic energy homeostasis and the overall oxidative capacity of insulin target tissues. Thus, these miRNAs provide potential targets for pharmacologic intervention in obesity and metabolic syndrome.
C1 [Carrer, Michele; Liu, Ning; Grueter, Chad E.; Williams, Andrew H.; Bassel-Duby, Rhonda; Olson, Eric N.] Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA.
   [Frisard, Madlyn I.; Hulver, Matthew W.] Virginia Tech Univ, Dept Human Nutr Foods & Exercise, Blacksburg, VA 24061 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center Dallas; Virginia Polytechnic Institute & State University
RP Olson, EN (corresponding author), Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA.
EM Eric.Olson@utsouthwestern.edu
RI Bassel-Duby, Rhonda/HJP-5742-2023; Olson, Eric/B-4391-2013
OI Carrer, Michele/0000-0002-6464-9584; Bassel-Duby,
   Rhonda/0000-0001-7568-410X; Olson, Eric N./0000-0003-1151-8262; Grueter,
   Chad/0000-0001-8950-742X
FU American Heart Association; National Institutes of Health; Robert A.
   Welch Foundation [I-0025]; Jon Holden DeHaan Foundation; Donald W.
   Reynolds Center for Clinical Cardiovascular Research; Fondation Leducq
   TransAtlantic Network of Excellence in Cardiovascular Research Program;
   Cancer Prevention and Research Institute of Texas
FX We thank Steven Kliewer, Michael Haberland, Douglas Millay, Craig
   Malloy, Viviana Moresi, and James A. Richardson for insightful
   discussions; Ryan McMillan, Cheryl Nolen and John McAnally for technical
   support; and Jose Cabrera for graphics. M.C. was supported by a
   Predoctoral Fellowship from the American Heart Association. Work in the
   laboratory of Eric Olson was supported by grants from the National
   Institutes of Health, Robert A. Welch Foundation (Grant I-0025),
   American Heart Association, Jon Holden DeHaan Foundation, Donald W.
   Reynolds Center for Clinical Cardiovascular Research, Fondation Leducq
   TransAtlantic Network of Excellence in Cardiovascular Research Program,
   and Cancer Prevention and Research Institute of Texas.
CR Anderson EJ, 2009, J CLIN INVEST, V119, P573, DOI 10.1172/JCI37048
   Bartel DP, 2004, CELL, V116, P281, DOI 10.1016/S0092-8674(04)00045-5
   Bonnard C, 2008, J CLIN INVEST, V118, P789, DOI 10.1172/JCI32601
   Cordente AG, 2004, J BIOL CHEM, V279, P33899, DOI 10.1074/jbc.M402685200
   Dang CV, 2012, GENE DEV, V26, P877, DOI 10.1101/gad.189365.112
   Dill H, 2012, GENE DEV, V26, P25, DOI 10.1101/gad.177774.111
   Djuranovic S, 2011, SCIENCE, V331, P550, DOI 10.1126/science.1191138
   Eichner LJ, 2010, CELL METAB, V12, P352, DOI 10.1016/j.cmet.2010.09.002
   Esterbauer H, 1999, GENOMICS, V62, P98, DOI 10.1006/geno.1999.5977
   Filipowicz W, 2008, NAT REV GENET, V9, P102, DOI 10.1038/nrg2290
   Finck BN, 2006, J CLIN INVEST, V116, P615, DOI 10.1172/JCI27794
   Frezza C, 2007, NAT PROTOC, V2, P287, DOI 10.1038/nprot.2006.478
   Frisard MI, 2010, AM J PHYSIOL-ENDOC M, V298, pE988, DOI 10.1152/ajpendo.00307.2009
   Frost RJA, 2011, P NATL ACAD SCI USA, V108, P21075, DOI 10.1073/pnas.1118922109
   Gagan J, 2011, J BIOL CHEM, V286, P19431, DOI 10.1074/jbc.M111.219006
   Ge K, 2002, NATURE, V417, P563, DOI 10.1038/417563a
   Gerin I, 2010, AM J PHYSIOL-ENDOC M, V299, pE198, DOI 10.1152/ajpendo.00179.2010
   Gianotti TF, 2008, OBESITY, V16, P1591, DOI 10.1038/oby.2008.253
   Grueter CE, 2012, CELL, V149, P671, DOI 10.1016/j.cell.2012.03.029
   Haberland M, 2010, J BIOL CHEM, V285, P14663, DOI 10.1074/jbc.M109.081679
   Handschin C, 2006, ENDOCR REV, V27, P728, DOI 10.1210/er.2006-0037
   Hulver MW, 2005, CELL METAB, V2, P251, DOI 10.1016/j.cmet.2005.09.002
   Ito M, 2001, TRENDS ENDOCRIN MET, V12, P127, DOI 10.1016/S1043-2760(00)00355-6
   John E, 2012, NUCLEIC ACIDS RES, V40, P4446, DOI 10.1093/nar/gks025
   Knezevic I, 2012, J BIOL CHEM, V287, P12913, DOI 10.1074/jbc.M111.331751
   Koves TR, 2005, J BIOL CHEM, V280, P33588, DOI 10.1074/jbc.M507621200
   Kusunoki J, 2006, ENDOCRINE, V29, P91, DOI 10.1385/ENDO:29:1:91
   Lelliott CJ, 2006, PLOS BIOL, V4, P2042, DOI 10.1371/journal.pbio.0040369
   Leung AKL, 2010, MOL CELL, V40, P205, DOI 10.1016/j.molcel.2010.09.027
   Li J, 2010, CELL METAB, V12, P154, DOI 10.1016/j.cmet.2010.07.003
   Lopaschuk GD, 2010, PHYSIOL REV, V90, P207, DOI 10.1152/physrev.00015.2009
   Maassen JA, 2007, DIABETOLOGIA, V50, P2036, DOI 10.1007/s00125-007-0776-z
   Malik S, 2004, MOL CELL BIOL, V24, P8244, DOI 10.1128/MCB.24.18.8244-8254.2004
   Malik S, 2010, NAT REV GENET, V11, P761, DOI 10.1038/nrg2901
   Mendell JT, 2012, CELL, V148, P1172, DOI 10.1016/j.cell.2012.02.005
   Näär AM, 2011, CELL METAB, V14, P149, DOI 10.1016/j.cmet.2011.07.005
   Najafi-Shoushtari SH, 2010, SCIENCE, V328, P1566, DOI 10.1126/science.1189123
   Noland RC, 2009, J BIOL CHEM, V284, P22840, DOI 10.1074/jbc.M109.032888
   O'Donnell JM, 2002, BIOPHYS J, V82, P11, DOI 10.1016/S0006-3495(02)75369-1
   Pospisilik JA, 2010, CELL, V140, P148, DOI 10.1016/j.cell.2009.12.027
   Rottiers V, 2012, NAT REV MOL CELL BIO, V13, P239, DOI 10.1038/nrm3313
   Small EM, 2011, NATURE, V469, P336, DOI 10.1038/nature09783
   Sonoda J, 2007, P NATL ACAD SCI USA, V104, P5223, DOI 10.1073/pnas.0611623104
   Trajkovski M, 2011, NATURE, V474, P649, DOI 10.1038/nature10112
   van Rooij E, 2008, P NATL ACAD SCI USA, V105, P13027, DOI 10.1073/pnas.0805038105
   van Rooij E, 2009, DEV CELL, V17, P662, DOI 10.1016/j.devcel.2009.10.013
   Vergnes L, 2011, J BIOL CHEM, V286, P380, DOI 10.1074/jbc.M110.184754
   Vianna CR, 2006, CELL METAB, V4, P453, DOI 10.1016/j.cmet.2006.11.003
   Wang QB, 2002, J BIOL CHEM, V277, P42852, DOI 10.1074/jbc.M206061200
   Wang SS, 2008, DEV CELL, V15, P261, DOI 10.1016/j.devcel.2008.07.002
   Zhu H, 2011, CELL, V147, P81, DOI 10.1016/j.cell.2011.08.033
NR 51
TC 246
Z9 273
U1 1
U2 37
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD SEP 18
PY 2012
VL 109
IS 38
BP 15330
EP 15335
DI 10.1073/pnas.1207605109
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 012BS
UT WOS:000309211000056
PM 22949648
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Atteia, HH
   Ahmed, SF
   Askar, ME
   Sakr, AT
AF Atteia, Hebatallah Husseini
   Ahmed, Salwa Fares
   Askar, Mervat El-Sayed
   Sakr, Amr Tawfik
TI Utilizing a Combination of Supplements Comprising Boric Acid, Magnesium,
   Vitamin D3, and Extra Virgin Olive Oil to Improve Metabolism in
   Menopausal Ovariectomized Rats
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article; Early Access
DE Dyslipidemia; Inflammation; Insulin signaling; Menopause; Metabolic
   syndrome
ID TUMOR-NECROSIS-FACTOR; C-REACTIVE PROTEIN; BORON-CONTAINING COMPOUNDS;
   SERUM-LIPID PROFILES; DOUBLE-BLIND; BLOOD-PRESSURE; NORMAL-WEIGHT;
   RISK-FACTORS; POSTMENOPAUSAL WOMEN; DIETARY MAGNESIUM
AB Metabolic syndrome during menopause can lead to diabetes, cardiovascular problems, and increased mortality rates. Hormone replacement therapy is recommended to manage climacteric complications, but it has serious adverse effects. This study, therefore, investigated the potential of supplementing some minerals, vitamins, and natural products like boric acid, magnesium, vitamin D3, and extra virgin olive oil on metabolic status of menopausal ovariectomized rats. Fourty-two female adult rats were randomly assigned to seven groups: a) Sham Control, b) Ovariectomized Control, c) Ovariectomized + Boric acid, d) Ovariectomized + Magnesium, e) Ovariectomized + Vitamin D3, f) Ovariectomized + Extra virgin olive oil, and g) Ovariectomized + Combined treatment groups. Serum inflammatory and oxidative stress markers, serum lipogram pattern, hepatic triglycerides, body weight, fasting blood glucose, serum insulin, leptin, and adiponectin, as well as hepatic insulin signaling cascade, IRS1/pAKT/GLUT4 were measured in each group to assess metabolic function. Results revealed a significant improvement in inflammation, oxidative stress, and metabolic parameters by individual and concomitant treating ovariectomized rats with boric acid, magnesium, vitamin D3, and extra virgin olive oil. Interestingly, the concurrent use of these supplements displayed a better impact than individual use, suggesting their valuable therapeutic potential for managing metabolic syndrome in menopausal women. However, the necessity of all four supplements for optimal therapeutic effects remains unsubstantiated.
C1 [Atteia, Hebatallah Husseini] Univ Tabuk, Fac Pharm, Dept Pharmaceut Chem, Tabuk, Saudi Arabia.
   [Ahmed, Salwa Fares] Univ Tabuk, Fac Med, Dept Anat, Tabuk, Saudi Arabia.
   [Askar, Mervat El-Sayed] Zagazig Univ, Fac Pharm, Dept Biochem, Zagazig 44519, Egypt.
   [Sakr, Amr Tawfik] Univ Sadat City USC, Fac Pharm, Dept Biochem, Menoufia, Egypt.
C3 University of Tabuk; University of Tabuk; Egyptian Knowledge Bank (EKB);
   Zagazig University; Egyptian Knowledge Bank (EKB); University of Sadat
   City
RP Atteia, HH (corresponding author), Univ Tabuk, Fac Pharm, Dept Pharmaceut Chem, Tabuk, Saudi Arabia.
EM hatteia@ut.edu.sa
RI Ahmed, Salwa/LCE-4091-2024; Atteia, Hebatallah/AFS-3313-2022
FU the Deanship of Scientific Research at the University of Tabuk in Saudi
   Arabia [0027-1444-S]; Deanship of Research and Graduate Studies at
   University of Tabuk
FX The authors extend their appreciation to the Deanship of Research and
   Graduate Studies at University of Tabuk for funding this work through
   Research no. 0027-1444-S.
CR Acaroz U, 2018, FOOD CHEM TOXICOL, V118, P745, DOI 10.1016/j.fct.2018.06.029
   Agarwal K, 2020, J OBSTET GYN INDIA, V70, P184, DOI 10.1007/s13224-020-01314-8
   Al Alawi AM, 2018, INT J ENDOCRINOL, V2018, DOI 10.1155/2018/9041694
   Alharazy S, 2021, BMC ENDOCR DISORD, V21, DOI 10.1186/s12902-021-00825-3
   Armstrong TA, 2003, J ANIM SCI, V81, P2552
   Ashraf H., 2021, Egypt J Nutr, V36, P37, DOI [10.21608/enj.2021.177744, DOI 10.21608/ENJ.2021.177744]
   Atabek ME, 2006, PEDIATR INT, V48, P393, DOI 10.1111/j.1442-200X.2006.02227.x
   Aysan E, 2011, INT J MED SCI, V8, P653, DOI 10.7150/ijms.8.653
   Babaei Parvin, 2017, J Menopausal Med, V23, P182, DOI 10.6118/jmm.2017.23.3.182
   Babaei P, 2017, DIABETOL METAB SYNDR, V9, DOI 10.1186/s13098-017-0288-z
   Babaei P, 2015, PHYSIOL PHARMACOL, V19, P200
   Babaei Parvin, 2015, J Exerc Nutrition Biochem, V19, P173, DOI 10.5717/jenb.2015.15070703
   Babaei Parvin, 2010, Menopause Int, V16, P100, DOI 10.1258/mi.2010.010028
   Bah S, 2018, E MEDITERR HEALTH J, V24, P401, DOI 10.26719/2018.24.4.401
   Bain LKM, 2015, INT J CARDIOL, V196, P108, DOI 10.1016/j.ijcard.2015.05.166
   Bakken NA, 2003, J NUTR, V133, P3577, DOI 10.1093/jn/133.11.3577
   Balliett M, 2013, J CHIROPR MED, V12, P3, DOI 10.1016/j.jcm.2012.11.003
   Barbagallo M, 2009, MAGNESIUM RES, V22, P235, DOI 10.1684/mrh.2009.0187
   Bartha T, 2005, DOMEST ANIM ENDOCRIN, V29, P193, DOI 10.1016/j.domaniend.2005.03.010
   Bayat Zeinab, 2023, J Menopausal Med, V29, P29, DOI 10.6118/jmm.22037
   BERSOHN I, 1957, LANCET, V1, P1020
   Bhasker TV, 2016, J TRACE ELEM MED BIO, V36, P73, DOI 10.1016/j.jtemb.2016.04.007
   Bo S, 2008, CURR OPIN LIPIDOL, V19, P50, DOI 10.1097/MOL.0b013e3282f33ccc
   Bourgonje AR, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21010314
   Brodowski J, 2000, Przegl Lek, V57, P714
   Çakir S, 2024, BIOL TRACE ELEM RES, V202, P1001, DOI 10.1007/s12011-023-03910-x
   Cakir S, 2018, BIOL TRACE ELEM RES, V184, P165, DOI 10.1007/s12011-017-1182-0
   Capatina Cristina, 2014, Maedica (Bucur), V9, P316
   Carr MC, 2003, J CLIN ENDOCR METAB, V88, P2404, DOI 10.1210/jc.2003-030242
   Cassidy A, 2009, J NUTR, V139, P353, DOI 10.3945/jn.108.098681
   Cat AND, 2013, ANTIOXID REDOX SIGN, V19, P1110, DOI 10.1089/ars.2012.4641
   Cheung AT, 2000, DIABETES, V49, P810, DOI 10.2337/diabetes.49.5.810
   Choi MiKyeong Choi MiKyeong, 2005, Korean Journal of Nutrition, V38, P698
   Cioffi M, 2002, MATURITAS, V41, P187, DOI 10.1016/S0378-5122(01)00286-9
   Considine RV, 1996, NEW ENGL J MED, V334, P292, DOI 10.1056/NEJM199602013340503
   Cordeiro MM, 2021, LIFE SCI, V278, DOI 10.1016/j.lfs.2021.119550
   Córdova-Chávez RI, 2022, BIOL TRACE ELEM RES, DOI 10.1007/s12011-022-03346-9
   Crandall CJ, 2023, JAMA-J AM MED ASSOC, V329, P405, DOI 10.1001/jama.2022.24140
   Cullinen Kathleen, 2006, Med Health R I, V89, P113
   da Silva AR, 2013, MATURITAS, V76, P64, DOI 10.1016/j.maturitas.2013.05.015
   Melo SRD, 2022, BIOMETALS, V35, P689, DOI 10.1007/s10534-022-00393-6
   Dogan A, 2017, METABOLISM, V69, P130, DOI 10.1016/j.metabol.2017.01.021
   Donoiu I, 2018, J TRACE ELEM MED BIO, V50, P47, DOI 10.1016/j.jtemb.2018.06.003
   dos Santos LR, 2021, BIOL TRACE ELEM RES, V199, P4020, DOI 10.1007/s12011-020-02528-7
   Doshi Sejal B, 2013, J Midlife Health, V4, P140, DOI 10.4103/0976-7800.118990
   Durakoglugil M, 2005, J NEUROCHEM, V95, P396, DOI 10.1111/j.1471-4159.2005.03375.x
   Elseweidy MM, 2017, BIOMED PHARMACOTHER, V85, P155, DOI 10.1016/j.biopha.2016.11.116
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   Anderson-Vasquez HE, 2015, NUTR HOSP, V31, P2561, DOI 10.3305/nh.2015.31.6.8732
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Farrin N, 2022, J TRACE ELEM MED BIO, V72, DOI 10.1016/j.jtemb.2022.126969
   Filip R, 2015, J NUTR HEALTH AGING, V19, P77, DOI 10.1007/s12603-014-0480-x
   Fiorentini D, 2021, NUTRIENTS, V13, DOI 10.3390/nu13041136
   Fox EM, 2013, BREAST CANCER RES, V15, DOI 10.1186/bcr3449
   Gaman MA, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051411
   Giacometti J, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21238981
   Gloy Viktoria, 2011, Biol Sex Differ, V2, P6, DOI 10.1186/2042-6410-2-6
   González-Hedström D, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-87628-7
   GRUNFELD C, 1990, ENDOCRINOLOGY, V127, P46, DOI 10.1210/endo-127-1-46
   Guerrero-Romero F, 2015, DIABETES METAB, V41, P202, DOI 10.1016/j.diabet.2015.03.010
   Guerrero-Romero F, 2019, EUR J CLIN INVEST, V49, DOI 10.1111/eci.13093
   Guerrero-Romero F, 2016, EUR J INTERN MED, V34, P29, DOI 10.1016/j.ejim.2016.06.015
   Guerrero-Romero F, 2013, EUR J INTERN MED, V24, P639, DOI 10.1016/j.ejim.2013.02.014
   Gündüz E, 2023, INT J MORPHOL, V41, P368
   Han MY, 2024, HYPERTENS RES, V47, P331, DOI 10.1038/s41440-023-01439-z
   Hosgörler F, 2020, BIOL TRACE ELEM RES, V196, P545, DOI 10.1007/s12011-019-01944-8
   Hunt Curtiss D., 1991, Magnesium and Trace Elements, V10, P387
   Ince S, 2010, J TRACE ELEM MED BIO, V24, P161, DOI 10.1016/j.jtemb.2010.01.003
   Itoh K, 1997, BRIT J NUTR, V78, P737, DOI 10.1079/BJN19970191
   Jeong HG, 2022, METABOLITES, V12, DOI 10.3390/metabo12100954
   Jimenez-Lopez C, 2020, FOODS, V9, DOI 10.3390/foods9081014
   Jiménez-Sánchez A, 2022, NUTRIENTS, V14, DOI 10.3390/nu14071440
   Jin HF, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111760
   Kaisar HH, 2020, EGYPT LIVER J, V10, DOI 10.1186/s43066-020-00049-5
   Kamath S, 2016, RES J PHARM BIOL CHE, V7, P791
   Kamran M, 2019, BIOL TRACE ELEM RES, V190, P396, DOI 10.1007/s12011-018-1555-z
   Karatekeli S, 2023, J TRACE ELEM MED BIO, V77, DOI 10.1016/j.jtemb.2023.127127
   Khalfa A, 2017, INT J GYNECOL OBSTET, V138, P201, DOI 10.1002/ijgo.12206
   Khaliq H, 2018, BIOL TRACE ELEM RES, V186, P31, DOI 10.1007/s12011-018-1284-3
   Kim DS, 2014, NUTR METAB, V11, DOI 10.1186/1743-7075-11-44
   Ko SH, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010202
   Kouhestani Somayeh, 2018, J Menopausal Med, V24, P169, DOI 10.6118/jmm.2018.24.3.169
   Kristiansen OP, 2005, DIABETES, V54, pS114, DOI 10.2337/diabetes.54.suppl_2.S114
   Kucukkurt I, 2023, J BIOCHEM MOL TOXIC, V37, DOI 10.1002/jbt.23257
   Kucukkurt I, 2015, TOXICOL IND HEALTH, V31, P255, DOI 10.1177/0748233712469648
   Kumar R, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.12178
   Kuru R, 2019, J TRACE ELEM MED BIO, V54, P191, DOI 10.1016/j.jtemb.2019.04.021
   Lee TW, 2015, NUTR RES, V35, P269, DOI 10.1016/j.nutres.2015.02.005
   Li YC, 2002, J CLIN INVEST, V110, P229, DOI [10.1172/JCI200215219, 10.1172/JCI0215219]
   Liu AP, 2020, J TRACE ELEM MED BIO, V59, DOI 10.1016/j.jtemb.2020.126470
   López-Cabrera Y, 2018, J TRACE ELEM MED BIO, V50, P424, DOI 10.1016/j.jtemb.2018.08.009
   López-González B, 2014, NUTR HOSP, V29, P658, DOI [10.3305/nh.2014.29.3.7198, 10.3305/NH.2014.29.3.7198]
   Lwow F, 2020, EXP GERONTOL, V141, DOI 10.1016/j.exger.2020.111107
   Maksimenko Alexander V, 2012, Heart Int, V7, pe3, DOI 10.4081/hi.2012.e3
   Malutan AM, 2014, MENOPAUSE REV, V13, P162, DOI 10.5114/pm.2014.43818
   Manna P, 2017, ARCH BIOCHEM BIOPHYS, V615, P22, DOI 10.1016/j.abb.2017.01.002
   Martins D, 2007, ARCH INTERN MED, V167, P1159, DOI 10.1001/archinte.167.11.1159
   Mehndiratta N, 2020, J MID-LIFE HEALTH, V11, P17, DOI 10.4103/jmh.JMH_57_19
   Min W, 2018, EXP GERONTOL, V113, P106, DOI 10.1016/j.exger.2018.09.027
   Naghii MR, 2011, J TRACE ELEM MED BIO, V25, P54, DOI 10.1016/j.jtemb.2010.10.001
   Nielsen FH, 2011, J EVID-BASED INTEGR, V16, P169, DOI 10.1177/2156587211407638
   Nielsen FH, 2010, NUTR REV, V68, P333, DOI 10.1111/j.1753-4887.2010.00293.x
   Orlova S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12072062
   Ozorowski M, 2022, NUTR METAB, V19, DOI 10.1186/s12986-022-00666-4
   Pacini Stefania, 2008, Italian Journal of Anatomy and Embryology, V113, P55
   Parvizi MR, 2014, J DIABETES METAB DIS, V13, DOI 10.1186/s40200-014-0084-3
   Paz-Filho Gilberto, 2012, Indian J Endocrinol Metab, V16, pS549, DOI 10.4103/2230-8210.105571
   Pérez-López FR, 2020, THER ADV ENDOCRINOL, V11, DOI 10.1177/2042018820931291
   Pestel J, 2023, BIOCHIMIE, V212, P48, DOI 10.1016/j.biochi.2023.04.008
   PETERSEN B, 1976, ACTA MED SCAND, V200, P59
   Pham PCT, 2007, CLIN J AM SOC NEPHRO, V2, P366, DOI 10.2215/CJN.02960906
   Piuri G, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020320
   Porri D, 2021, NFS J, V23, P30, DOI 10.1016/j.nfs.2021.03.003
   Qi L, 2005, DIABETES CARE, V28, P1022, DOI 10.2337/diacare.28.5.1022
   Raman V, 2023, CUREUS J MED SCIENCE, V15, DOI 10.7759/cureus.39069
   Rammos G, 2008, INT UROL NEPHROL, V40, P419, DOI 10.1007/s11255-007-9244-4
   Reddy AM, 2022, EXCLI J, V21, P967, DOI 10.17179/excli2022-4935
   Rezazadeh H, 2021, EUR J PHARMACOL, V909, DOI 10.1016/j.ejphar.2021.174418
   Ródenas S, 2005, J AM COLL NUTR, V24, P361, DOI 10.1080/07315724.2005.10719486
   Rodríguez-Moran M, 2014, ARCH MED RES, V45, P388, DOI 10.1016/j.arcmed.2014.05.003
   Rogoveanu OC, 2015, BIOL TRACE ELEM RES, V163, P124, DOI 10.1007/s12011-014-0155-9
   Rosanoff A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010195
   Ruel G, 2014, CLIN NUTR, V33, P513, DOI 10.1016/j.clnu.2013.07.009
   Saleh NK, 2010, EXP GERONTOL, V45, P964, DOI 10.1016/j.exger.2010.08.015
   Salehidoost R, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-20277-6
   Sánchez-Rodríguez MA, 2012, MENOPAUSE, V19, P361, DOI 10.1097/gme.0b013e318229977d
   Saral S, 2021, EUR CYTOKINE NETW, V32, P31, DOI 10.1684/ecn.2021.0467
   Schmitt EB, 2018, MATURITAS, V107, P97, DOI 10.1016/j.maturitas.2017.10.011
   Schwingshackl L, 2015, NUTRIENTS, V7, P7651, DOI 10.3390/nu7095356
   Morais JBS, 2017, BIOL TRACE ELEM RES, V176, P20, DOI 10.1007/s12011-016-0793-1
   Simental-Mendía LE, 2014, ARCH MED RES, V45, P325, DOI 10.1016/j.arcmed.2014.04.006
   de Oliveira ARS, 2017, REV ASSOC MED BRAS, V63, P156, DOI 10.1590/1806-9282.63.02.156
   Sohrabipour S, 2018, FUND CLIN PHARMACOL, V32, P603, DOI 10.1111/fcp.12387
   Solaimani H, 2014, CAN J PHYSIOL PHARM, V92, P438, DOI 10.1139/cjpp-2013-0403
   Solati Mehrdad, 2019, Med J Islam Repub Iran, V33, P2, DOI 10.34171/mjiri.33.2
   Son HJ, 2020, KOREAN J INTERN MED, V35, P310, DOI 10.3904/kjim.2018.098
   Song YQ, 2007, AM J CLIN NUTR, V85, P1068, DOI 10.1093/ajcn/85.4.1068
   Sundari LPR, 2020, CURR RES NUTR FOOD S, V8, P541, DOI 10.12944/CRNFSJ.8.2.20
   Tacer KF, 2007, PHYSIOL GENOMICS, V31, P216, DOI 10.1152/physiolgenomics.00264.2006
   Taleb-Belkadi O, 2016, GYNECOL ENDOCRINOL, V32, P982, DOI 10.1080/09513590.2016.1214257
   Tawfik SH, 2015, BIOCHEM RES INT, V2015, DOI 10.1155/2015/567945
   Tekeli H, 2021, CELL MOL BIOL, V67, P313, DOI 10.14715/cmb/2021.67.4.35
   Touliat MV, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-29540-w
   Turan E., 2018, Arch Clin Exp Med, V3, P71, DOI [10.25000/acem.419847, DOI 10.25000/ACEM.419847]
   Uluisik I, 2018, J TRACE ELEM MED BIO, V45, P156, DOI 10.1016/j.jtemb.2017.10.008
   Vazquez A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081728
   Wang F, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0104450
   Wei CC, 2017, J NUTR, V147, P1070, DOI 10.3945/jn.116.245852
   Witayavanitkul N, 2020, BMC COMPLEMENT MED, V20, DOI 10.1186/s12906-020-02962-z
   Yavuzer H, 2018, HASEKI TIP BUL, V56, P213, DOI 10.4274/haseki.3831
   Yin K, 2014, J INFLAMM RES, V7, P69, DOI 10.2147/JIR.S63898
   Yoon L, 2015, J MED FOOD, V18, P738, DOI 10.1089/jmf.2014.3287
   Zheltova AA, 2016, BIOMEDICINE-TAIWAN, V6, P8, DOI 10.7603/s40681-016-0020-6
   Zheng XH, 2016, EXP THER MED, V11, P1881, DOI 10.3892/etm.2016.3138
NR 154
TC 0
Z9 0
U1 6
U2 6
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD 2024 DEC 28
PY 2024
DI 10.1007/s12011-024-04476-y
EA DEC 2024
PG 16
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA Q5N0B
UT WOS:001385131500001
PM 39731655
DA 2025-06-11
ER

PT J
AU Aursulesei, V
   Bulughiana, S
   Stoica, BA
   Anisie, E
AF Aursulesei, Viviana
   Bulughiana, Siminela
   Stoica, Bogdan Alexandru
   Anisie, Ecaterina
TI Circulating Chemerin, Oxidative Stress, Inflammation and Insulin
   Resistance in Morbid Obesity
SO REVISTA DE CHIMIE
LA English
DT Article
DE chemerin; oxidative stress; inflammation; insulin resistance
ID ADIPOSE-TISSUE; METABOLIC SYNDROME; FATTY LIVER; WEIGHT-LOSS;
   ADIPOKINES; ASSOCIATION; MARKERS; PLASMA; ROLES
AB Chemerin is a relatively novel adipokine with controversial pathophysiological role in obesity. Our study aimed to investigate the relationship of serum chemerin level with inflammation, oxidative stress and insulin resistance in morbidly obese subjects. Circulating chemerin was an independent predictor of TNF-Q level, superoxide dismutase activity and lipid peroxidation, but no relation with insulin resistance could be sustained. Taken together chemerin could be a marker of dysfunctional adipose tissue, but its serum level does not reflect properly the metabolic phenotype in morbid obesity.
C1 [Aursulesei, Viviana] Grigore T Popa Univ Med & Pharm, Fac Med, Med Dept 1, 16 Univ Str, Iasi 700115, Romania.
   [Aursulesei, Viviana; Bulughiana, Siminela] Sf Spiridon Emergency Dist Clin Hosp, Dept Cardiol, 1 Independenei Sq, Iasi 700111, Romania.
   [Stoica, Bogdan Alexandru] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Biochem, 16 Univ Str, Iasi 700115, Romania.
   [Anisie, Ecaterina] Sf Spiridon Emergency Dist Clin Hosp, Immunol & Genet Lab, 1 Independenei Sq, Iasi 700111, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy
RP Aursulesei, V (corresponding author), Grigore T Popa Univ Med & Pharm, Fac Med, Med Dept 1, 16 Univ Str, Iasi 700115, Romania.; Aursulesei, V (corresponding author), Sf Spiridon Emergency Dist Clin Hosp, Dept Cardiol, 1 Independenei Sq, Iasi 700111, Romania.
EM aursuleseiv@yahoo.com
RI Stoica, Bogdan/C-6418-2012; ONOFREI AURSULESEI, VIVIANA/AGY-3366-2022
OI ONOFREI AURSULESEI, VIVIANA/0000-0002-2762-0918
FU Grigore T. Popa University of Medicine and Pharmacy [31583]
FX This research was financed by the Grigore T. Popa University of Medicine
   and Pharmacy by contract no. 31583/23.12.2015.
CR Alfadda AA, 2012, MOL CELLS, V33, P591, DOI 10.1007/s10059-012-0012-7
   Ali TM., 2013, Beni-Suef Univ J Basic Appl Sci, V2, P86, DOI [10.1016/j.bjbas.2013.02.001, DOI 10.1016/J.BJBAS.2013.02.001]
   Bozaoglu K, 2007, ENDOCRINOLOGY, V148, P4687, DOI 10.1210/en.2007-0175
   Bozaoglu K, 2009, J CLIN ENDOCR METAB, V94, P3085, DOI 10.1210/jc.2008-1833
   Bryan S, 2013, CAN J PHYSIOL PHARM, V91, P22, DOI 10.1139/cjpp-2012-0295
   Catoi Adriana Florinela, 2014, Clujul Med, V87, P19, DOI 10.15386/cjm.2014.8872.871.afc1
   Chakaroun R, 2012, METABOLISM, V61, P706, DOI 10.1016/j.metabol.2011.10.008
   Chu SH, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034710
   CORONA-MERAZ F.I., INVERSE RELATIONSHIP
   Fatima SS, 2014, PEPTIDES, V62, P15, DOI 10.1016/j.peptides.2014.09.019
   Ferland DJ, 2015, PHARMACOL RES, V99, P351, DOI 10.1016/j.phrs.2015.07.018
   FRIEDEWALD WT, 1972, CLIN CHEM, V18
   Fülöp P, 2014, J CELL MOL MED, V18, P1313, DOI 10.1111/jcmm.12282
   Jialal I, 2013, J CLIN ENDOCR METAB, V98, pE514, DOI 10.1210/jc.2012-3673
   Jung UJ, 2014, INT J MOL SCI, V15, P6184, DOI 10.3390/ijms15046184
   Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2548, DOI 10.1210/jc.2004-0395
   Kim SH, 2014, CLIN ENDOCRINOL, V80, P825, DOI 10.1111/cen.12249
   Lehrke M, 2009, EUR J ENDOCRINOL, V161, P339, DOI 10.1530/EJE-09-0380
   Li YJ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0090340
   Mattern A, 2014, IUBMB LIFE, V66, P19, DOI 10.1002/iub.1242
   Mattu HS, 2013, J ENDOCRINOL, V216, pT17, DOI 10.1530/JOE-12-0232
   Mittal PC, 2009, CLIN BIOCHEM, V42, P1007, DOI 10.1016/j.clinbiochem.2009.03.019
   Olivares-Corichi IM, 2011, HORM METAB RES, V43, P748, DOI 10.1055/s-0031-1286305
   Parlee SD, 2010, ENDOCRINOLOGY, V151, P2590, DOI 10.1210/en.2009-0794
   Piya MK, 2013, J ENDOCRINOL, V216, pT1, DOI 10.1530/JOE-12-0498
   Ress C, 2010, EUR J CLIN INVEST, V40, P277, DOI 10.1111/j.1365-2362.2010.02255.x
   Sell H, 2010, J CLIN ENDOCR METAB, V95, P2892, DOI 10.1210/jc.2009-2374
   Sledzinski T, 2013, J ENDOCRINOL INVEST, V36, P428, DOI 10.3275/8770
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Tinahones FJ, 2009, OBESITY, V17, P240, DOI 10.1038/oby.2008.536
   Virdis A, 2015, EUR HEART J, V36, P784, DOI 10.1093/eurheartj/ehu072
   Viroonudomphol Duangkamol, 2000, Southeast Asian Journal of Tropical Medicine and Public Health, V31, P325
   Weigert J, 2010, CLIN ENDOCRINOL, V72, P342, DOI 10.1111/j.1365-2265.2009.03664.x
   Yamawaki H, 2012, BIOCHEM BIOPH RES CO, V423, P152, DOI 10.1016/j.bbrc.2012.05.103
   Yu S, 2012, CHINESE MED J-PEKING, V125, P3440, DOI 10.3760/cma.j.issn.0366-6999.2012.19.015
NR 35
TC 8
Z9 8
U1 0
U2 5
PU REVISTA CHIMIE SRL
PI BUCURESTI
PA CALES PLEVNEI NR 139A, SECTOR 6, BUCURESTI, ROMANIA
SN 0034-7752
J9 REV CHIM-BUCHAREST
JI Rev. Chim.
PD MAY
PY 2017
VL 68
IS 5
BP 1014
EP 1018
PG 5
WC Chemistry, Multidisciplinary; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering
GA FB0DY
UT WOS:000405816300026
DA 2025-06-11
ER

PT J
AU Chade, AR
   Lerman, A
   Lerman, LO
AF Chade, AR
   Lerman, A
   Lerman, LO
TI Kidney in early atherosclerosis
SO HYPERTENSION
LA English
DT Review
DE kidney; atherosclerosis; oxidative stress; fibrosis
ID LOW-DENSITY-LIPOPROTEIN; CARDIOVASCULAR-DISEASE RISK; GLYCATION
   END-PRODUCTS; CHRONIC-RENAL-FAILURE; 3RD NATIONAL-HEALTH; C-REACTIVE
   PROTEIN; OXIDATIVE STRESS; METABOLIC SYNDROME; INCREASED PREVALENCE;
   MECHANICAL STRETCH
AB Atherosclerosis represents one of the major causes of premature death in the United States today, and it is frequently associated with, exacerbates, and is aggravated by chronic kidney disease (CKD). Atherosclerosis integrates the response to a number of insults, and consequently, the accelerated atherosclerosis found in CKD patients is associated with activation of a variety of humoral and tissue mechanisms. Hypertension, diabetes, dyslipidemia, obesity, metabolic syndrome, and additional nontraditional risk factors can damage the kidney directly and by promoting intrarenal atherogenesis, even in the absence of obstructive lesions in the renal artery. Evidence indicates that increased oxidative stress and inflammation may mediate a large part of the effects of risk factors on the kidney. In turn, progressive deterioration of renal function in CKD may lead to dyslipidemia or accumulation of uremic toxins, which can induce production of free radicals and activate proinflammatory and fibrogenic factors, leading to vascular endothelial cell dysfunction and injury, and favoring development of atherosclerosis. Therefore, the kidney can be a villain or a victim during atherogenesis. The purpose of this review is to provide new insights into the mechanisms by which atherogenic factors may instigate early renal injury.
C1 Mayo Clin, Coll Med, Div Nephrol & Hypertens, Dept Internal Med, Rochester, MN 55905 USA.
   Mayo Clin, Div Cardiovasc Dis, Rochester, MN USA.
C3 Mayo Clinic; Mayo Clinic
RP Mayo Clin, Coll Med, Div Nephrol & Hypertens, Dept Internal Med, Rochester, MN 55905 USA.
EM Lerman.Lilach@Mayo.Edu
RI Lerman, Lilach/M-4962-2017
FU NHLBI NIH HHS [HL-77131, K24-HL69840, HL-63282] Funding Source: Medline
CR Abrass CK, 2004, AM J NEPHROL, V24, P46, DOI 10.1159/000075925
   Amann K, 2003, CLIN NEPHROL, V60, pS13
   Amann K, 2002, KIDNEY INT, V62, P877, DOI 10.1046/j.1523-1755.2002.00518.x
   [Anonymous], 2003, USRDS 2003 ANN DAT R
   Ares Mikko P S, 2002, BMC Immunol, V3, P13, DOI 10.1186/1471-2172-3-13
   Arici M, 2001, KIDNEY INT, V59, P407, DOI 10.1046/j.1523-1755.2001.059002407.x
   Baggio B, 2001, J NEPHROL, V14, P286
   Bax L, 2003, EUR J CLIN INVEST, V33, P34, DOI 10.1046/j.1365-2362.2003.01091.x
   Becker BN, 1998, EXP NEPHROL, V6, P57
   Bentley MD, 2002, KIDNEY INT, V61, P1056, DOI 10.1046/j.1523-1755.2002.00211.x
   Brenner B., 1976, The Kidney, V2
   Brown WW, 2003, AM J KIDNEY DIS, V42, P22, DOI 10.1016/S0272-6386(03)00405-0
   Buckalew VM, 1996, AM J KIDNEY DIS, V28, P811, DOI 10.1016/S0272-6386(96)90380-7
   Chade AR, 2003, HYPERTENSION, V42, P605, DOI 10.1161/01.HYP.0000089880.32275.7C
   Chade AR, 2005, J AM SOC NEPHROL, V16, P1005, DOI 10.1681/ASN.2004080674
   Chade AR, 2004, J AM SOC NEPHROL, V15, P1816, DOI 10.1097/01.ASN.0000130428.85603.6B
   Chade AR, 2004, AM J PHYSIOL-RENAL, V286, pF1079, DOI 10.1152/ajprenal.00385.2003
   Chade AR, 2004, J AM SOC NEPHROL, V15, P958, DOI 10.1097/01.ASN.0000117774.83396.E9
   Chade AR, 2003, KIDNEY INT, V64, P962, DOI 10.1046/j.1523-1755.2003.00170.x
   Chade AR, 2003, ARTERIOSCL THROM VAS, V23, P1295, DOI 10.1161/01.ATV.0000077477.40824.52
   Chade AR, 2003, AM J HYPERTENS, V16, P111, DOI 10.1016/S08957061(02)03202-8
   Chade AR, 2002, CIRCULATION, V106, P1165, DOI 10.1161/01.CIR.0000027105.02327.48
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Chrysohoou C, 2004, AM J HYPERTENS, V17, P568, DOI 10.1016/j.amjhyper.2004.03.675
   Collins AJ, 2003, KIDNEY INT, V64, pS24, DOI 10.1046/j.1523-1755.64.s87.5.x
   Coresh J, 2004, CURR OPIN NEPHROL HY, V13, P73, DOI 10.1097/00041552-200401000-00011
   Coresh J, 2001, ARCH INTERN MED, V161, P1207, DOI 10.1001/archinte.161.9.1207
   Costa LA, 2004, DIABETIC MED, V21, P252, DOI 10.1111/j.1464-5491.2004.01124.x
   Crook ED, 2003, AM J MED SCI, V325, P340, DOI 10.1097/00000441-200306000-00005
   de Jong PE, 2002, INT J OBESITY, V26, pS21, DOI 10.1038/sj.ijo.0802213
   Deppisch RM, 2001, KIDNEY INT, V59, pS271, DOI 10.1046/j.1523-1755.2001.59780271.x
   Dominguez JH, 2000, KIDNEY INT, V57, P92, DOI 10.1046/j.1523-1755.2000.00814.x
   Eckel RH, 2002, CIRCULATION, V105, P2923, DOI 10.1161/01.CIR.0000017823.53114.4C
   Eddy AA, 1996, KIDNEY INT, V50, P1139, DOI 10.1038/ki.1996.421
   Eddy AA, 2002, AM J PHYSIOL-RENAL, V283, pF209, DOI 10.1152/ajprenal.00032.2002
   Eknoyan G, 2002, AM J KIDNEY DIS, V39, pS14, DOI 10.1053/ajkd.2002.30939
   El-Atat FA, 2004, J AM SOC NEPHROL, V15, P2816, DOI 10.1097/01.ASN.0000133698.80390.37
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Fox CS, 2004, JAMA-J AM MED ASSOC, V291, P844, DOI 10.1001/jama.291.7.844
   Grote K, 2003, CIRC RES, V92, pE80, DOI 10.1161/01.RES.0000077044.60138.7C
   GUIJARRO C, 1995, AM J KIDNEY DIS, V26, P152, DOI 10.1016/0272-6386(95)90169-8
   Hall JE, 2003, CURR OPIN NEPHROL HY, V12, P195, DOI 10.1097/00041552-200303000-00011
   Hall JE, 1999, ANN NY ACAD SCI, V892, P91, DOI 10.1111/j.1749-6632.1999.tb07788.x
   Handelman GJ, 2001, KIDNEY INT, V59, P1960, DOI 10.1046/j.1523-1755.2001.0590051960.x
   Hansen KJ, 2002, J VASC SURG, V36, P443, DOI 10.1067/mva.2002.127351
   Hedley AA, 2004, JAMA-J AM MED ASSOC, V291, P2847, DOI 10.1001/jama.291.23.2847
   Henegar JR, 2001, J AM SOC NEPHROL, V12, P1211, DOI 10.1681/ASN.V1261211
   Himmelfarb J, 2002, KIDNEY INT, V62, P1524, DOI 10.1046/j.1523-1755.2002.00600.x
   Hörkkö S, 2000, FREE RADICAL BIO MED, V28, P1771, DOI 10.1016/S0891-5849(00)00333-6
   Hou FF, 2004, J AM SOC NEPHROL, V15, P1889, DOI 10.1097/01.asn.0000131526.99506.f7
   Hunsicker LG, 2004, J AM SOC NEPHROL, V15, P1363, DOI 10.1097/01.ASN.0000126069.68755.99
   Ishimura E, 2001, AM J KIDNEY DIS, V38, pS186, DOI 10.1053/ajkd.2001.27440
   Joki N, 2000, HYPERTENS RES, V23, P91, DOI 10.1291/hypres.23.91
   Kamanna VS, 1999, KIDNEY INT, V55, P2192, DOI 10.1046/j.1523-1755.1999.00470.x
   Kamanna VS, 1998, HISTOL HISTOPATHOL, V13, P169, DOI 10.14670/HH-13.169
   Kamanna VS, 1997, CURR OPIN NEPHROL HY, V6, P205, DOI 10.1097/00041552-199705000-00001
   Kaysen GA, 2004, J AM SOC NEPHROL, V15, P538, DOI 10.1097/01.ASN.0000111744.00916.E6
   KEANE WF, 1988, AM J NEPHROL, V8, P261, DOI 10.1159/000167599
   KEANE WF, 1988, AM J CLIN NUTR, V47, P157, DOI 10.1093/ajcn/47.1.157
   Khan MA, 2000, ADV RENAL REPLACE TH, V7, P32, DOI 10.1016/S1073-4449(00)70004-5
   Khot UN, 2003, JAMA-J AM MED ASSOC, V290, P898, DOI 10.1001/jama.290.7.898
   Knott HM, 2003, EUR J BIOCHEM, V270, P3572, DOI 10.1046/j.1432-1033.2003.03742.x
   Kumar V., 2003, Robbins Basic Pathology
   Lea JP, 2002, J NATL MED ASSOC, V94, p7S
   Lee SH, 2003, KIDNEY INT, V64, P1012, DOI 10.1046/j.1523-1755.2003.00158.x
   Lerman LO, 1996, KIDNEY INT, V49, P846, DOI 10.1038/ki.1996.117
   Lim PS, 2002, BLOOD PURIFICAT, V20, P537, DOI 10.1159/000066962
   Lombardo A, 2004, CIRCULATION, V109, P3158, DOI 10.1161/01.CIR.0000130786.28008.56
   Ludewig B, 2002, TRENDS CARDIOVAS MED, V12, P154, DOI 10.1016/S1050-1738(01)00166-9
   LYONS TJ, 1993, AM J CARDIOL, V71, pB26, DOI 10.1016/0002-9149(93)90142-Y
   Magil AB, 1999, MODERN PATHOL, V12, P33
   MANTTARI M, 1995, HYPERTENSION, V26, P670, DOI 10.1161/01.HYP.26.4.670
   Massy ZA, 1999, NEPHROL DIAL TRANSPL, V14, P2392, DOI 10.1093/ndt/14.10.2392
   Mathur S, 2002, CURR OPIN NEPHROL HY, V11, P141, DOI 10.1097/00041552-200203000-00003
   McGill HC, 1998, ARTERIOSCL THROM VAS, V18, P1108, DOI 10.1161/01.ATV.18.7.1108
   Meyrier A, 1998, KIDNEY INT, V54, P2, DOI 10.1046/j.1523-1755.1998.00968.x
   Minami M, 2000, BIOCHEM BIOPH RES CO, V272, P357, DOI 10.1006/bbrc.2000.2778
   Motojima M, 2003, KIDNEY INT, V63, P1671, DOI 10.1046/j.1523-1755.2003.00906.x
   Muntner P, 2000, KIDNEY INT, V58, P293, DOI 10.1046/j.1523-1755.2000.00165.x
   Naito T, 2001, J Atheroscler Thromb, V8, P55
   O'Hare AM, 2004, CIRCULATION, V109, P320, DOI 10.1161/01.CIR.0000114519.75433.DD
   Oberg BP, 2004, KIDNEY INT, V65, P1009, DOI 10.1111/j.1523-1755.2004.00465.x
   Obrador GT, 2002, SEMIN NEPHROL, V22, P441, DOI 10.1053/snep.2002.2002.35962
   Rajagopalan S, 1996, J CLIN INVEST, V97, P1916, DOI 10.1172/JCI118623
   Roh DD, 1998, AM J NEPHROL, V18, P344, DOI 10.1159/000013363
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Sakata N, 1999, ATHEROSCLEROSIS, V142, P67, DOI 10.1016/S0021-9150(98)00192-0
   Saran R, 2003, NEPHROL DIAL TRANSPL, V18, P2415, DOI 10.1093/ndt/gfg406
   Schelling JR, 2004, J AM SOC NEPHROL, V15, P2773, DOI 10.1097/01.ASN.0000141964.68839.BB
   SEIFERT PS, 1989, LAB INVEST, V60, P747
   SEIFERT PS, 1989, ARTERIOSCLEROSIS, V9, P802, DOI 10.1161/01.ATV.9.6.802
   Shlipak MG, 2002, KIDNEY INT, V62, P997, DOI 10.1046/j.1523-1755.2002.00522.x
   Shurrab AE, 2003, NEPHRON CLIN PRACT, V93, pC51, DOI 10.1159/000068521
   Stengel B, 2003, EPIDEMIOLOGY, V14, P479, DOI 10.1097/01.EDE.0000071413.55296.c4
   Stenvinkel P, 2003, J RENAL NUTR, V13, P144, DOI 10.1053/jren.2003.50018
   STOUT RW, 1993, BIOMED PHARMACOTHER, V47, P1, DOI 10.1016/0753-3322(93)90029-K
   Suresh M, 2000, NEPHROL DIAL TRANSPL, V15, P631, DOI 10.1093/ndt/15.5.631
   TANAKA M, 1993, EXP ANIM TOKYO, V42, P203, DOI 10.1538/expanim1978.42.2_203
   Textor SC, 2004, J AM SOC NEPHROL, V15, P1974, DOI 10.1097/01.ASN.0000133699.97353.24
   TOLINS JP, 1992, KIDNEY INT, V41, P1254, DOI 10.1038/ki.1992.187
   Trivedi HS, 2002, AM J KIDNEY DIS, V39, P721, DOI 10.1053/ajkd.2002.31990
   Uzu T, 2002, HYPERTENS RES, V25, P537
   Varadhachary AS, 2001, CELL IMMUNOL, V213, P45, DOI 10.1006/cimm.2001.1855
   Wilcox CS, 2002, CURR HYPERTENS REP, V4, P160, DOI 10.1007/s11906-002-0041-2
   Wilson SH, 2003, NEPHROL DIAL TRANSPL, V18, P703, DOI 10.1093/ndt/gfg143
   Wisse BE, 2004, J AM SOC NEPHROL, V15, P2792, DOI 10.1097/01.ASN.0000141966.69934.21
   Yeun JY, 2000, CURR OPIN NEPHROL HY, V9, P621, DOI 10.1097/00041552-200011000-00006
   Zhou MS, 2004, HYPERTENSION, V44, P186, DOI 10.1161/01.HYP.0000136395.06810.cf
   Zhou WD, 2001, KIDNEY INT, V59, P1227, DOI 10.1046/j.1523-1755.2001.0590041227.x
   Zoccali C, 2003, KIDNEY INT, V63, pS105, DOI 10.1046/j.1523-1755.63.s85.25.x
NR 110
TC 139
Z9 152
U1 1
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD JUN
PY 2005
VL 45
IS 6
BP 1042
EP 1049
DI 10.1161/01.HYP.0000167121.14254.a0
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 930DS
UT WOS:000229396600003
PM 15897370
DA 2025-06-11
ER

PT J
AU Lee, HS
   Park, T
AF Lee, Ho-Sun
   Park, Taesung
TI Pathway-Driven Approaches of Interaction between Oxidative Balance and
   Genetic Polymorphism on Metabolic Syndrome
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID GENOME-WIDE ASSOCIATION; C-REACTIVE PROTEIN; ENVIRONMENT INTERACTIONS;
   CARDIOVASCULAR-DISEASE; COLORECTAL ADENOMA; STRESS; INFLAMMATION;
   CANCER; SCORE; RISK
AB Despite evidences of association between basic redox biology and metabolic syndrome (MetS), few studies have evaluated indices that account for multiple oxidative effectors for MetS. Oxidative balance score (OBS) has indicated the role of oxidative stress in chronic disease pathophysiology. In this study, we evaluated OBS as an oxidative balance indicator for estimating risk of MetS with 6414 study participants. OBS is a multiple exogenous factor score for development of disease; therefore, we investigated interplay between oxidative balance and genetic variation for development of MetS focusing on biological pathways by using gene-setenrichment analysis. As a result, participants in the highest quartile of OBS were less likely to be at risk for MetS than those in the lowest quartile. In addition, persons in the highest quartile of OBS had the lowest level of inflammatory markers including Creactive protein andWBC. With GWAS-based pathway analysis, we found that VEGF signaling pathway, glutathione metabolism, and Rac-1 pathway were significantly enriched biological pathways involved with OBS on MetS. These findings suggested that mechanism of angiogenesis, oxidative stress, and inflammation can be involved in interaction between OBS and genetic variation on risk of MetS.
C1 [Park, Taesung] Seoul Natl Univ, Interdisciplinary Program Bioinformat, Seoul 152742, South Korea.
   Seoul Natl Univ, Dept Stat, Seoul 152742, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU)
RP Park, T (corresponding author), Seoul Natl Univ, Interdisciplinary Program Bioinformat, Seoul 152742, South Korea.
EM tspark@stats.snu.ac.kr
RI Lee, Ho-Sun/AAD-6112-2019
OI Park, Taesung/0000-0002-8294-590X; Lee, Ho-Sun/0000-0003-2864-015X
FU Bio-Synergy Research Project of the Ministry of Science, ICT and Future
   Planning through the National Research Foundation [2013M3A9C4078158];
   National Research Foundation of Korea [22A20151713442] Funding Source:
   Korea Institute of Science & Technology Information (KISTI), National
   Science & Technology Information Service (NTIS)
FX This work was supported by the Bio-Synergy Research Project of the
   Ministry of Science, ICT and Future Planning through the National
   Research Foundation (2013M3A9C4078158).
CR Ahn Y, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-61
   Amer Diabet Assoc, 2016, DIABETES CARE, V39, pS13, DOI 10.2337/dc16-S005
   Andreassi MG, 2009, MUTAT RES-FUND MOL M, V667, P35, DOI 10.1016/j.mrfmmm.2008.10.018
   Annor FB, 2015, J AM SOC HYPERTENS, V9, P592, DOI 10.1016/j.jash.2015.05.014
   Armutcu F, 2008, CLIN CHEM LAB MED, V46, P785, DOI 10.1515/CCLM.2008.166
   Bae JC, 2015, J DIABETES, V7, P791, DOI 10.1111/1753-0407.12248
   Cho NH, 2015, DIABETES CARE, V38, P1333, DOI 10.2337/dc14-1931
   Cho YS, 2009, NAT GENET, V41, P527, DOI 10.1038/ng.357
   Cowey S, 2006, AM J PATHOL, V169, P1505, DOI 10.2353/ajpath.2006.051090
   Dash C, 2015, AM J EPIDEMIOL, V181, P584, DOI 10.1093/aje/kwu318
   Elnakish MT, 2013, J PATHOL, V231, P290, DOI 10.1002/path.4255
   Esposito K, 2012, DIABETES CARE, V35, P2402, DOI 10.2337/dc12-0336
   Fall T, 2014, MOL CELL ENDOCRINOL, V382, P740, DOI 10.1016/j.mce.2012.08.018
   Fernández-Garcia JC, 2013, CURR VASC PHARMACOL, V11, P906, DOI 10.2174/15701611113116660175
   Fusco D, 2007, CLIN INTERV AGING, V2, P377
   Gao MJ, 2015, REDOX BIOL, V6, P206, DOI 10.1016/j.redox.2015.06.013
   Hunter DJ, 2005, NAT REV GENET, V6, P287, DOI 10.1038/nrg1578
   Hwaiz R, 2013, J SURG RES, V183, P798, DOI 10.1016/j.jss.2013.02.045
   Ilori TO, 2015, AM J NEPHROL, V42, P320, DOI 10.1159/000441623
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kim YW, 2014, BLOOD, V123, P625, DOI 10.1182/blood-2013-09-512749
   Kong SY, 2015, ANN EPIDEMIOL, V25, P256, DOI 10.1016/j.annepidem.2015.01.004
   Kong SYJ, 2014, CANCER EPIDEM BIOMAR, V23, P545, DOI 10.1158/1055-9965.EPI-13-0619
   Kotani K, 2012, INT J PREVENTIVE MED, V3, P428
   Kowluru RA, 2015, BBA-MOL BASIS DIS, V1852, P2474, DOI 10.1016/j.bbadis.2015.08.001
   Labadie J, 2013, ANN EPIDEMIOL, V23, P223, DOI 10.1016/j.annepidem.2012.12.001
   Lakkur S, 2015, ATHEROSCLEROSIS, V243, P38, DOI 10.1016/j.atherosclerosis.2015.08.032
   Lakkur S, 2014, ANN EPIDEMIOL, V24, P475, DOI 10.1016/j.annepidem.2014.02.015
   Le Marchand L, 2008, CANCER EPIDEM BIOMAR, V17, P263, DOI 10.1158/1055-9965.EPI-07-0402
   Lee CD, 2001, AM J EPIDEMIOL, V154, P758, DOI 10.1093/aje/154.8.758
   Li WD, 2015, SCI REP-UK, V5, DOI 10.1038/srep13422
   Yubero-Serrano EM, 2013, EXP MOL MED, V45, DOI 10.1038/emm.2013.53
   Mittal M, 2014, ANTIOXID REDOX SIGN, V20, P1126, DOI 10.1089/ars.2012.5149
   Pearson TA, 2003, CIRCULATION, V107, P499, DOI 10.1161/01.CIR.0000052939.59093.45
   Pei C, 2015, EUR J INTERN MED, V26, P324, DOI 10.1016/j.ejim.2015.04.009
   Poljsak B, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/956792
   Reuter S, 2010, FREE RADICAL BIO MED, V49, P1603, DOI 10.1016/j.freeradbiomed.2010.09.006
   Satoh M, 2006, P NATL ACAD SCI USA, V103, P7432, DOI 10.1073/pnas.0510444103
   Singh SK, 2008, ANN MED, V40, P110, DOI 10.1080/07853890701749225
   Slattery ML, 2014, INT J CANCER, V134, P629, DOI 10.1002/ijc.28377
   Slattery ML, 2012, MUTAT RES-FUND MOL M, V734, P30, DOI 10.1016/j.mrfmmm.2012.04.002
   Smith ADAC, 2013, BRIT J NUTR, V109, P1881, DOI 10.1017/S0007114512003868
   Stephens JW, 2008, ATHEROSCLEROSIS, V200, P229, DOI 10.1016/j.atherosclerosis.2008.04.003
   Thomas DC, 2005, CANCER EPIDEM BIOMAR, V14, P557, DOI 10.1158/1055-9965.EPI-14-3-EDB
   Thomas D, 2010, ANNU REV PUBL HEALTH, V31, P21, DOI 10.1146/annurev.publhealth.012809.103619
   Tiwari Brahm Kumar, 2013, J Biomark, V2013, P378790, DOI 10.1155/2013/378790
   Torkamani A, 2008, GENOMICS, V92, P265, DOI 10.1016/j.ygeno.2008.07.011
   Wang K, 2007, AM J HUM GENET, V81, P1278, DOI 10.1086/522374
   Wang K, 2010, NAT REV GENET, V11, P843, DOI 10.1038/nrg2884
   Wu GY, 2004, J NUTR, V134, P489, DOI 10.1093/jn/134.10.2783S
   Zhang KL, 2015, PROTEIN CELL, V6, P221, DOI 10.1007/s13238-014-0114-4
NR 51
TC 31
Z9 35
U1 0
U2 4
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2017
VL 2017
AR 6873197
DI 10.1155/2017/6873197
PG 9
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA EK7RF
UT WOS:000394122200001
PM 28191276
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Lasker, S
   Rahman, MM
   Parvez, F
   Zamila, M
   Miah, P
   Nahar, K
   Kabir, F
   Sharmin, SB
   Subhan, N
   Ahsan, GU
   Alam, MA
AF Lasker, Shoumen
   Rahman, Md Mizanur
   Parvez, Faisal
   Zamila, Mushfera
   Miah, Pintu
   Nahar, Kamrun
   Kabir, Fariha
   Sharmin, Surovi Binte
   Subhan, Nusrat
   Ahsan, Gias U.
   Alam, Md Ashraful
TI High-fat diet-induced metabolic syndrome and oxidative stress in obese
   rats are ameliorated by yogurt supplementation
SO SCIENTIFIC REPORTS
LA English
DT Article
ID LACTIC-ACID BACTERIA; LACTOBACILLUS-ACIDOPHILUS; INSULIN-RESISTANCE; GUT
   MICROBIOTA; LIVER; CHOLESTEROL; PROBIOTICS; PRODUCTS; CONSUMPTION;
   CHILDREN
AB The main objective of this experiment was to determine the effects of yogurt supplementation on fat deposition, oxidative stress, inflammation and fibrosis in the liver of rats with high-fat (HF) diet-induced obesity. Male Wistar rats were used in this study and were separated into the following four different groups: the control, control + yogurt, high fat and high fat + yogurt groups. The high fat groups received a HF diet for eight weeks. A 5% yogurt (w/w) supplement was also provided to rats fed the HF diet. Yogurt supplementation prevented glucose intolerance and normalized liver-specific enzyme activities in the HF diet-fed rats. Yogurt supplementation also significantly reduced the levels of oxidative stress markers in the plasma and liver of HF diet-fed rats. Moreover, inflammatory cell infiltration, collagen deposition and fibrosis in the liver of HF diet-fed rats were also prevented by yogurt supplementation. Furthermore, yogurt supplementation normalized the intestinal lining and brush border in HF diet-fed rats. This study suggests that yogurt supplementation potentially represents an alternative therapy for the prevention of metabolic syndrome in HF diet-fed rats.
C1 [Lasker, Shoumen; Rahman, Md Mizanur; Parvez, Faisal; Zamila, Mushfera; Miah, Pintu; Nahar, Kamrun; Kabir, Fariha; Sharmin, Surovi Binte; Subhan, Nusrat; Alam, Md Ashraful] North South Univ, Dept Pharmaceut Sci, Dhaka 1219, Bangladesh.
   [Ahsan, Gias U.] North South Univ, Dept Publ Hlth, Sch Hlth & Life Sci, Dhaka 1219, Bangladesh.
C3 North South University (NSU); North South University (NSU)
RP Alam, MA (corresponding author), North South Univ, Dept Pharmaceut Sci, Dhaka 1219, Bangladesh.; Ahsan, GU (corresponding author), North South Univ, Dept Publ Hlth, Sch Hlth & Life Sci, Dhaka 1219, Bangladesh.
EM gias.ahsan@northsouth.edu; sonaliagun@yahoo.com
RI Nahar, Dr.Kamrun/JFS-9212-2023; Mohona, Surovi/AAG-4129-2020; Ahsan,
   Gias/AAN-8794-2020; Alam, Ashraful/G-1964-2014; Rahman, Md
   Mizanur/AAC-7666-2019
OI Miah, Pintu/0000-0002-8535-7214; Rahman, Md Mizanur/0000-0002-7178-7977;
   Mohona, Surovi Binte Sharmin/0000-0002-0360-9714; Alam, Md
   Ashraful/0000-0001-7596-5868; Kabir, Fariha/0000-0001-6412-5257; Zamila,
   Mushfera/0000-0002-2904-9436
CR Abu-Elsaad NM, 2015, J MED FOOD, V18, P950, DOI 10.1089/jmf.2014.0104
   Adolfsson O, 2004, AM J CLIN NUTR, V80, P245, DOI 10.1093/ajcn/80.2.245
   Afifi NA, 2017, CAN J PHYSIOL PHARM, V95, P427, DOI 10.1139/cjpp-2016-0269
   Akiyama T, 1996, DIABETES RES CLIN PR, V31, P27, DOI 10.1016/0168-8227(96)01205-3
   Al-muzafar HM, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-016-1540-z
   Amar J, 2011, EMBO MOL MED, V3, P559, DOI 10.1002/emmm.201100159
   Anderson JW, 1999, J AM COLL NUTR, V18, P43, DOI 10.1080/07315724.1999.10718826
   Bakhshimoghaddam F, 2018, J NUTR, V148, P1276, DOI 10.1093/jn/nxy088
   Begley M, 2006, APPL ENVIRON MICROB, V72, P1729, DOI 10.1128/AEM.72.3.1729-1738.2006
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Chen XL, 2013, ANIMAL, V7, P287, DOI 10.1017/S1751731112001528
   Esposito E, 2009, J NUTR, V139, P905, DOI 10.3945/jn.108.101808
   Gao DW, 2011, J MED PLANTS RES, V5, P1439
   Grundy Scott M, 2006, Clin Cornerstone, V8 Suppl 1, pS21, DOI 10.1016/S1098-3597(06)80005-0
   Haga Y, 2015, WORLD J GASTROENTERO, V21, P12989, DOI 10.3748/wjg.v21.i46.12989
   Hill JO, 2012, CIRCULATION, V126, P126, DOI 10.1161/CIRCULATIONAHA.111.087213
   Hod K., 2018, J NEUROGASTROENTEROL, V30
   Hruby A, 2015, PHARMACOECONOMICS, V33, P673, DOI 10.1007/s40273-014-0243-x
   Hu LH, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0170238
   Hummel S, 2012, APPL ENVIRON MICROB, V78, P1140, DOI 10.1128/AEM.06983-11
   JOLLOW DJ, 1974, PHARMACOLOGY, V11, P151, DOI 10.1159/000136485
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Khan RA, 2012, BMC COMPLEM ALTERN M, V12, DOI 10.1186/1472-6882-12-181
   Kim SJ, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030293
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Kumar M, 2012, EXP DIABETES RES, DOI 10.1155/2012/902917
   Lee BJ, 2011, J NEUROGASTROENTEROL, V17, P252, DOI 10.5056/jnm.2011.17.3.252
   Lee JH, 2009, NUTR RES PRACT, V3, P114, DOI 10.4162/nrp.2009.3.2.114
   Loguercio C, 2002, AM J GASTROENTEROL, V97, P2144
   Lye HS, 2010, J DAIRY SCI, V93, P1383, DOI 10.3168/jds.2009-2574
   Mach T, 2006, J PHYSIOL PHARMACOL, V57, P23
   Marette A, 2014, AM J CLIN NUTR, V99, p1243S, DOI 10.3945/ajcn.113.073379
   Mi YJ, 2015, AM J PREV MED, V49, P661, DOI 10.1016/j.amepre.2015.05.005
   MISRA HP, 1972, J BIOL CHEM, V247, P3170
   Mohammadi AA, 2015, INT J PREVENTIVE MED, V6, DOI 10.4103/2008-7802.164146
   Nabavi S, 2014, J DAIRY SCI, V97, P7386, DOI 10.3168/jds.2014-8500
   Naito E, 2011, J APPL MICROBIOL, V110, P650, DOI 10.1111/j.1365-2672.2010.04922.x
   NIEHAUS WG, 1968, EUR J BIOCHEM, V6, P126, DOI 10.1111/j.1432-1033.1968.tb00428.x
   Ogawa Y., 2015, Innovative Medicine: Basic Research and Development, P149
   Öner-Iyidogan Y, 2013, J PHYSIOL BIOCHEM, V69, P677, DOI 10.1007/s13105-013-0244-9
   Ooi LG, 2010, INT J MOL SCI, V11, P2499, DOI 10.3390/ijms11062499
   Petrie JR, 2018, CAN J CARDIOL, V34, P575, DOI 10.1016/j.cjca.2017.12.005
   Pradere JP, 2013, HEPATOLOGY, V58, P1461, DOI 10.1002/hep.26429
   Qin N, 2014, NATURE, V513, P59, DOI 10.1038/nature13568
   Ragab SMM, 2015, LIPIDS HEALTH DIS, V14, DOI 10.1186/s12944-015-0087-1
   Rahman MM, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0539-x
   S Lavekar Anurag, 2017, Euroasian J Hepatogastroenterol, V7, P130, DOI 10.5005/jp-journals-10018-1233
   Schnabl B, 2014, GASTROENTEROLOGY, V146, P1513, DOI 10.1053/j.gastro.2014.01.020
   Spence LA, 2011, CURR NUTR FOOD SCI, V7, P40, DOI 10.2174/157340111794941111
   Timmers S, 2011, NUTR DIABETES, V1, DOI 10.1038/nutd.2011.7
   Tiwari Brahm Kumar, 2014, ISRN Pharmacol, V2014, P608590, DOI 10.1155/2014/608590
   TRACEY WR, 1995, J PHARMACOL EXP THER, V272, P1011
   Ulla A, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1799-8
   Uskova M. A., 2009, Voprosy Pitaniya, V78, P18
   WitkoSarsat V, 1996, KIDNEY INT, V49, P1304, DOI 10.1038/ki.1996.186
   Xiao JZ, 2003, J DAIRY SCI, V86, P2452, DOI 10.3168/jds.S0022-0302(03)73839-9
   Yadav H, 2008, J DAIRY RES, V75, P189, DOI 10.1017/S0022029908003129
   Yeon SJ, 2015, KOREAN J FOOD SCI AN, V35, P479, DOI 10.5851/kosfa.2015.35.4.479
   Yu Linda Chia-Hui, 2012, World J Gastrointest Pathophysiol, V3, P27, DOI 10.4291/wjgp.v3.i1.27
NR 59
TC 162
Z9 171
U1 3
U2 42
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 27
PY 2019
VL 9
AR 20026
DI 10.1038/s41598-019-56538-0
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA KF5XV
UT WOS:000509315700029
PM 31882854
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kayikcioglu, M
   Payzin, S
   Yavuzgil, O
   Kultursay, H
   Can, LH
   Soydan, I
AF Kayikcioglu, M
   Payzin, S
   Yavuzgil, O
   Kultursay, H
   Can, LH
   Soydan, I
TI Benefits of statin treatment in cardiac syndrome-X
SO EUROPEAN HEART JOURNAL
LA English
DT Article; Proceedings Paper
CT 24th Congress of the European-Society-of-Cardiology
CY AUG 31-SEP 04, 2002
CL BERLIN, GERMANY
SP European Soc Cardiol
DE endothelium; inflammation; cardiac syndrome-X; exercise; pravastatin
ID NORMAL CORONARY ARTERIOGRAMS; NITRIC-OXIDE SYNTHASE; ANGINA-PECTORIS;
   ENDOTHELIAL DYSFUNCTION; 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE;
   PRAVASTATIN SODIUM; BLOOD RHEOLOGY; CHEST PAIN; CHOLESTEROL;
   VASODILATION
AB Aims The pathophysiological mechanism in cardiac syndrome-X (anginal chest pain, positive exercise test, and angiographically normal coronary arteries) has been suggested as an impairment in normal endothelial function of the coronary microvasculature, resulting in inadequate flow reserve. The aim of this study was to determine whether statins with proven beneficial effects on endothelium, have any effect on endothelial functions and exercise induced ischaemia in cardiac syndrome-X.
   Methods and results Study population consisted of prospectively enrolled 40 patients with cardiac syndrome-X. Patients with left ventricular hypertrophy, hypertension, diabetes mellitus, and LDL levels greater than or equal to160 mg/dl were excluded. Half of the patients received pravastatin (40 mg/day) for 3 months irrespective of their lipid values, according to a single-blind, randomized, placebo-controlled design. Endothelial functions were assessed with high-resolution vascular ultrasound, which measured the brachial artery flow mediated dilatation (FMD). Lipid measurements, symptom limited exercise tests and vascular ultrasound images were obtained before and at the end of 3 months. After the treatment, FMD improved significantly in pravastatin group. Exercise duration, and time to 1 mm-ST depression were significantly prolonged after statin therapy. Ischaemic symptoms and ECG findings during exercise test disappeared completely in 5 (26%) patients in the statin group. However, there were no significant changes in FMD and exercise parameters in placebo group.
   Conclusions Statin therapy resulted in beneficial effects on both exercise induced ischaemia and FMD in cardiac syndrome-X. The mechanism of this beneficial effect is probably the result of improvement in endothelial functions. (C) 2003 The European Society of Cardiology. Published by Elsevier Ltd. All rights reserved.
C1 Ege Univ, Sch Med, Dept Cardiol, Izmir, Turkey.
C3 Ege University
RP Kayikcioglu, M (corresponding author), Ege Univ, Sch Med, Dept Cardiol, Izmir, Turkey.
RI KAYIKCIOGLU, Meral/AAH-6687-2020
CR Atienza F, 1999, CLIN CARDIOL, V22, P283, DOI 10.1002/clc.4960220406
   Campeau L, 2002, CAN J CARDIOL, V18, P371
   CELERMAJER DS, 1992, LANCET, V340, P1111, DOI 10.1016/0140-6736(92)93147-F
   Chauhan A, 1997, EUR HEART J, V18, P60
   Corretti MC, 2002, J AM COLL CARDIOL, V39, P257, DOI 10.1016/S0735-1097(01)01746-6
   Dobrucki L W, 2001, Med Sci Monit, V7, P622
   EGASHIRA K, 1994, CIRCULATION, V89, P2519, DOI 10.1161/01.CIR.89.6.2519
   Egashira K, 1996, CIRCULATION, V94, P130, DOI 10.1161/01.CIR.94.2.130
   Egashira K, 2000, HYPERTENS RES, V23, P353, DOI 10.1291/hypres.23.353
   Fabian Emilia, 2002, Orv Hetil, V143, P2067
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Hernández-Perera O, 1998, J CLIN INVEST, V101, P2711, DOI 10.1172/JCI1500
   Kaesemeyer WH, 1999, J AM COLL CARDIOL, V33, P234, DOI 10.1016/S0735-1097(98)00514-2
   KEMP HG, 1991, J AM COLL CARDIOL, V17, P507, DOI 10.1016/S0735-1097(10)80123-8
   Kolasinska-Kloch W, 2002, SCAND J CLIN LAB INV, V62, P7, DOI 10.1080/003655102753517145
   Lanza GA, 1999, AM J CARDIOL, V84, P1187, DOI 10.1016/S0002-9149(99)00532-9
   Lekakis JP, 1998, J AM COLL CARDIOL, V31, P541, DOI 10.1016/S0735-1097(97)00542-1
   Lowe G, 2000, THROMB HAEMOSTASIS, V84, P553, DOI 10.1055/s-0037-1614066
   MASERI A, 1991, J AM COLL CARDIOL, V17, P499, DOI 10.1016/S0735-1097(10)80122-6
   Meeder JG, 1995, EUR HEART J, V16, P1571, DOI 10.1093/oxfordjournals.eurheartj.a060780
   MUNZEL T, 1995, J CLIN INVEST, V95, P187, DOI 10.1172/JCI117637
   Qian JY, 2000, AM HEART J, V140, P502, DOI 10.1067/mhj.2000.109221
   Rasmussen LM, 2001, BIOCHEM J, V360, P363, DOI 10.1042/0264-6021:3600363
   Rosenson R S, 1999, Curr Cardiol Rep, V1, P225, DOI 10.1007/s11886-999-0027-7
   Tousoulis D, 2001, CLIN CARDIOL, V24, P301, DOI 10.1002/clc.4960240409
   Tsuda Y, 1996, ATHEROSCLEROSIS, V122, P225, DOI 10.1016/0021-9150(95)05757-9
   Turczynski B, 1999, Pol Arch Med Wewn, V102, P979
   Wassmann S, 2003, ENDOTHELIUM-J ENDOTH, V10, P23, DOI 10.1080/10623320303357
NR 28
TC 133
Z9 144
U1 0
U2 12
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0195-668X
J9 EUR HEART J
JI Eur. Heart J.
PD NOV
PY 2003
VL 24
IS 22
BP 1999
EP 2005
DI 10.1016/S0195-668X(03)00478-0
PG 7
WC Cardiac & Cardiovascular Systems
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 745RN
UT WOS:000186702000004
PM 14613735
OA Bronze
DA 2025-06-11
ER

PT J
AU Saatcioglu, O
   Kalkan, M
   Fistikci, N
   Erek, S
   Kilic, KC
AF Saatcioglu, Omer
   Kalkan, Murat
   Fistikci, Nurhan
   Erek, Sakire
   Kilic, Kasim Candas
TI Relationship Between Metabolic Syndrome and Clinical Features, and Its
   Personal-Social Performance in Patients with Schizophrenia
SO PSYCHIATRIC QUARTERLY
LA English
DT Article
DE Schizophrenia; Metabolic syndrome; Antipsychotics; Functionality
ID QUALITY-OF-LIFE; ATYPICAL ANTIPSYCHOTICS; GLUCOSE-METABOLISM;
   DIABETES-MELLITUS; HIGH PREVALENCE; WEIGHT-GAIN; SCALE; RISK;
   DETERMINANTS; RELIABILITY
AB The aim of this study was to evaluate the metabolic syndrome (MS) criteria and also to investigate the effects of MS on medical treatment, clinical course and personal and social performance in patients with schizophrenia. One hundred-sixteen patients with schizophrenia were included in the study. Measurements of MS were calculated in all patients. Brief Psychiatric Rating Scale, Scale for the Assessment of Positive Symptoms, Scale for the Assessment of Negative Symptoms, Calgary Depression Scale for Schizophrenia, Personal and Social Performance Scale (PSP) were applied. The frequency of MS according to IDF criteria was 42.2 % among the patients. There was no significant difference between patients with and without MS in terms of age. The ratios of MS were 62.5 % for the group taking typical and atypical antipsychotics together and 35.7 % for the group taking two or more atypical antipsychotics together. The duration of disorder in patients with MS was higher than those without MS. Furthermore there was no significant difference between the schizophrenic patients with and without MS, in terms of PSP scores. Our findings showed that the duration of illness, high scores of BMI, use of clozapine or concurrent use of typical and atypical antipsychotics, depressive and negative symptoms of schizophrenia were significant risk factors for the development of MS.
C1 [Kalkan, Murat; Fistikci, Nurhan; Erek, Sakire] Bakirkoy Prof Dr Mazhar Osman Ruh Sagligi & Sinir, Bakirkoy Res & Training Hosp Psychiat Neurol & Ne, TR-34147 Istanbul, Turkey.
   [Kilic, Kasim Candas] Ankara Numune Training & Res Hosp, Psychiat Clin, TR-06100 Ankara, Turkey.
   [Saatcioglu, Omer] Isik Univ, Dept Psychol, TR-34398 Istanbul, Turkey.
C3 Istanbul Bakirkoy Mental Health & Neurology Training & Research
   Hospital; Ankara Numune Training & Research Hospital; Isik University
RP Fistikci, N (corresponding author), Bakirkoy Prof Dr Mazhar Osman Ruh Sagligi & Sinir, Bakirkoy Res & Training Hosp Psychiat Neurol & Ne, TR-34147 Istanbul, Turkey.
EM osaatcioglu@yahoo.com; kaiserkalkan@yahoo.com; nurhanfistikci@gmail.com;
   ereks@yahoo.com; corneum7@yahoo.com
RI Saatcioglu, Omer/ABF-8318-2020
OI Saatcioglu, Omer/0000-0002-5825-9029
CR ADDINGTON D, 1992, SCHIZOPHR RES, V6, P201, DOI 10.1016/0920-9964(92)90003-N
   Allison DB, 2001, J CLIN PSYCHIAT, V62, P22
   Altindag A, 2008, TURKIYEDE PSIKIYATRI, V10, P1
   Amer Diabet Assoc, 2004, DIABETES CARE, V27, P596, DOI 10.2337/diacare.27.2.596
   [Anonymous], 2006, IDF CONS WORLDW DEF
   [Anonymous], 2004, J CLIN PSYCHIAT, DOI DOI 10.4088/PCC.v06n0205
   [Anonymous], 2000, Noro Psikiyatr Arsivi
   Basu A, 2006, SCHIZOPHR RES, V86, P99, DOI 10.1016/j.schres.2006.04.014
   Bechdolf A, 2003, EUR ARCH PSY CLIN N, V253, P228, DOI 10.1007/s00406-003-0436-3
   Bermudes RA, 2006, PSYCHOSOMATICS, V47, P491, DOI 10.1176/appi.psy.47.6.491
   BIRCHWOOD M, 1990, BRIT J PSYCHIAT, V157, P853, DOI 10.1192/bjp.157.6.853
   Bodén R, 2009, SCHIZOPHR RES, V107, P232, DOI 10.1016/j.schres.2008.10.004
   Browne S, 2000, BRIT J PSYCHIAT, V176, P173, DOI 10.1192/bjp.176.2.173
   By Mayo Clinic Staff, 2004, MAYO FDN MED ED RES, V37, P454
   Carpiniello B, 1997, ACTA PSYCHIAT SCAND, V96, P235, DOI 10.1111/j.1600-0447.1997.tb10157.x
   Cerit C, 2008, TURK PSIKIYATR DERG, V19, P124
   Cohn T, 2004, CAN J PSYCHIAT, V49, P753, DOI 10.1177/070674370404901106
   Danaci AE, 2003, KLIN PSIKOFARMAKOL B, V13, P94
   De Hert M, 2006, INT CLIN PSYCHOPHARM, V21, pS11, DOI 10.1097/01.yic.0000201496.23259.85
   De Hert M, 2009, WORLD PSYCHIATRY, V8, P15
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Eren I, 2007, DUSUNEN ADAM, V20, P68
   Erkoc S., 1991, DUSUNEN ADAM, V4, P20
   Erkoc S., 1991, DUSUNEN ADAM, V4, P16
   Evrim U, 2007, KLIN PSIKOFARMAKOL B, V17, P207
   Ford ES, 2008, ANN EPIDEMIOL, V18, P165, DOI 10.1016/j.annepidem.2007.10.009
   Franz M, 1997, BRIT J PSYCHIAT, V170, P422, DOI 10.1192/bjp.170.5.422
   Haddad PM, 2007, CNS DRUGS, V21, P911, DOI 10.2165/00023210-200721110-00004
   Hägg S, 2006, INT CLIN PSYCHOPHARM, V21, P93
   Hagg S, 1998, J CLIN PSYCHIAT, V59, P294, DOI 10.4088/JCP.v59n0604
   Hanssens L, 2007, SCHIZOPHRENIA BULL, V33, P560
   Haupt DW, 2006, EUR NEUROPSYCHOPHARM, V16, pS149, DOI 10.1016/j.euroneuro.2006.06.003
   Heiskanen T, 2003, J CLIN PSYCHIAT, V64, P575, DOI 10.4088/JCP.v64n0513
   Henderson DC, 2000, AM J PSYCHIAT, V157, P975, DOI 10.1176/appi.ajp.157.6.975
   Huppert JD, 2001, SCHIZOPHR RES, V51, P171, DOI 10.1016/S0920-9964(99)00151-6
   Jacob Rajesh, 2008, Indian J Med Sci, V62, P23
   Jin Hua, 2002, Ann Clin Psychiatry, V14, P59, DOI 10.3109/10401230209147399
   Kaya MC, 2009, NOROPSIKIYATRI ARS, V46, P13
   Kilavuzu Metabolik Sendrom, 2009, METABOLIK SENDROM KI, P8
   Kolotkin RL, 2006, QUAL LIFE RES, V15, P587, DOI 10.1007/s11136-005-4627-4
   Kugo A, 2006, PSYCHIAT RES, V144, P49, DOI 10.1016/j.psychres.2005.06.012
   Lieberman JA, 2005, NEW ENGL J MED, V353, P1209, DOI 10.1056/NEJMoa051688
   McEvoy JP, 2005, SCHIZOPHR RES, V80, P19, DOI 10.1016/j.schres.2005.07.014
   Meyer JM, 2005, SCHIZOPHR RES, V80, P9, DOI 10.1016/j.schres.2005.07.015
   Morosini PL, 2000, ACTA PSYCHIAT SCAND, V101, P323, DOI 10.1111/j.1600-0447.2000.tb10933.x
   Newcomer JW, 2005, CNS DRUGS, V19, P1
   Nurkalem Z, 2007, TURK KARDIYOL DERN A, V35, P231
   OVERALL JE, 1962, PSYCHOL REP, V10, P799
   Öyekçin DG, 2009, ANADOLU PSIKIYATR DE, V10, P26
   PRUDO R, 1987, BRIT J PSYCHIAT, V150, P345, DOI 10.1192/bjp.150.3.345
   Ritsner M, 2000, J CLIN PSYCHIAT, V61, P880, DOI 10.4088/JCP.v61n1113
   Schatzberg AF, 2004, TREATMENT SCHIZOPHRE, P897
   Scheen AJ, 2007, DIABETES METAB, V33, P169, DOI 10.1016/j.diabet.2007.01.003
   Stroup TS, 2006, AM J PSYCHIAT, V163, P611, DOI 10.1176/appi.ajp.163.4.611
   SULLIVAN G, 1992, HOSP COMMUNITY PSYCH, V43, P794
   Thakore JH, 2005, BRIT J PSYCHIAT, V186, P455, DOI 10.1192/bjp.186.6.455
   Toalson P, 2004, PRIMARY CARE COMPANI, V60, P152
   Tsai AG, 2008, OBESITY, V16, P59, DOI 10.1038/oby.2007.8
   Van Gaal LF, 2006, EUR NEUROPSYCHOPHARM, V16, pS142, DOI 10.1016/j.euroneuro.2006.06.005
   Van Winkel R, 2008, J CLIN PSYCHIAT, V69, P472, DOI 10.4088/JCP.v69n0320
   Vural M., 2007, THESIS HAYDARPASLA N
   Wirshing DA, 2002, J CLIN PSYCHIAT, V63, P856, DOI 10.4088/JCP.v63n1002
NR 62
TC 7
Z9 7
U1 0
U2 22
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0033-2720
EI 1573-6709
J9 PSYCHIAT QUART
JI Psychiatr. Q.
PD JUN
PY 2016
VL 87
IS 2
BP 265
EP 280
DI 10.1007/s11126-015-9384-0
PG 16
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA DK1QL
UT WOS:000374688400006
PM 26174109
DA 2025-06-11
ER

PT J
AU Liu, L
   Huang, X
   Gao, JL
   Guo, YS
   Di, YQ
   Sun, SS
   Deng, XL
   Cao, J
AF Liu, Lu
   Huang, Xin
   Gao, Jinliao
   Guo, Yusong
   Di, Yanqi
   Sun, Shasha
   Deng, Xinli
   Cao, Jian
TI Improved endogenous epoxyeicosatrienoic acid production mends heart
   function via increased PGC 1α-mitochondrial functions in metabolic
   syndrome
SO JOURNAL OF PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Epoxyeicoastrienoic acids; PGC-1 alpha; Heme oxygenase-1; Mitochondrial
   function; Metabolic syndrome
ID SPONTANEOUSLY HYPERTENSIVE-RATS; SOLUBLE EPOXIDE HYDROLASE; HEME
   OXYGENASE-1; CARDIAC DYSFUNCTION; BLOOD-PRESSURE; UP-REGULATION;
   ADIPONECTIN; ADIPOCYTES; MODEL; HO-1
AB Metabolic syndrome (MS) is a combination of symptoms characterized by central obesity, hypertension, hyperglycemia, and hyperlipidemia, which together increase the risk of heart disease, stroke and diabetes. In our study, we hypothesized that an EET-agonist (AUDA) would increase expression of PGC 1 alpha and improve mitochondrial and endothelial functions, resulting in improved heart function in a rat model of MS. To investigate this, rats were randomly divided into four groups: 1) Control; 2) MS thorn ABCT; 3) MS thorn AUDA; and 4) MS thorn AUDA thorn SnMP. MS rats were fed a high-fructose diet for 16 weeks and developed elevated inflammatory mediators, oxidative stress, and significant decreases in fractional shortening and hemodynamic parameters, indicating cardiac dysfunction. Histology revealed myocardial fibrosis and myocyte hypertrophy. AUDA improves mitochondrial function proven by increase in mt copy number and ATP production and significantly increased expression of PGC-1 alpha and HO-1 in the rats and normalization of inflammatory cytokines, oxidative stress, and improves in cardiac function and myocardial fibrosis. These benefits were reversed by SnMP. Furthermore, AUDA increases eNOS but decreases iNOS expression which improved endothelial function. We therefore demonstrate that endogenous EET upregulation plays a novel role in protecting the heart from MS by regulating mitochondrial and endothelial function. (c) 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.
C1 [Liu, Lu; Huang, Xin; Gao, Jinliao; Guo, Yusong; Di, Yanqi; Sun, Shasha; Cao, Jian] Chinese Peoples Liberat Army Gen Hosp, Nanlou Div, Dept Geriatr Cardiol, Natl Clin Res Ctr Geriatr Dis, Beijing 100853, Peoples R China.
   [Deng, Xinli] Chinese Peoples Liberat Army Gen Hosp, Nanlou Lab, Med Dept, Beijing 100853, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Chinese People's
   Liberation Army General Hospital
RP Cao, J (corresponding author), Chinese Peoples Liberat Army Gen Hosp, Nanlou Div, Dept Geriatr Cardiol, Natl Clin Res Ctr Geriatr Dis, Beijing 100853, Peoples R China.; Deng, XL (corresponding author), Chinese Peoples Liberat Army Gen Hosp, Nanlou Lab, Med Dept, Beijing 100853, Peoples R China.
EM bjdxl@163.com; calvin301@163.com
OI Cao, Jian/0000-0001-6728-4587
FU National Natural Science Foundation of China [81270154]; Military Health
   Care Project Foundation [16BJZ15]
FX This work was supported by the National Natural Science Foundation of
   China (81270154) and Military Health Care Project Foundation (16BJZ15).
CR Abraham NG, 2016, TRENDS PHARMACOL SCI, V37, P17, DOI 10.1016/j.tips.2015.09.003
   Arany Z, 2005, CELL METAB, V1, P259, DOI 10.1016/j.cmet.2005.03.002
   Cao J, 2012, INT J HYPERTENS, V2012, DOI 10.1155/2012/628147
   Cao J, 2015, PROSTAG OTH LIPID M, V116, P76, DOI 10.1016/j.prostaglandins.2015.01.002
   Cao J, 2012, HYPERTENSION, V60, P467, DOI 10.1161/HYPERTENSIONAHA.112.193805
   Cao J, 2008, INT J MOL SCI, V9, P2388, DOI 10.3390/ijms9122388
   Cao J, 2009, INT J BIOCHEM CELL B, V41, P1025, DOI 10.1016/j.biocel.2008.10.025
   Chang W, 2017, J PHARMACOL SCI, V135, P156, DOI 10.1016/j.jphs.2017.11.009
   Chen TM, 2013, INT J MOL SCI, V14, P2684, DOI 10.3390/ijms14022684
   Dorn GW, 2015, CIRC RES, V116, P167, DOI 10.1161/CIRCRESAHA.116.303554
   Goldstein BJ, 2004, J CLIN ENDOCR METAB, V89, P2563, DOI 10.1210/jc.2004-0518
   Grundy SM, 2004, J CLIN ENDOCR METAB, V89, P2595, DOI 10.1210/jc.2004-0372
   He JL, 2016, J DIABETES, V8, P305, DOI 10.1111/1753-0407.12358
   Horinouchi T, 2013, J PHARMACOL SCI, V123, P85, DOI 10.1254/jphs.13R02CR
   Hull TD, 2016, JCI INSIGHT, V1, DOI 10.1172/jci.insight.85817
   Ilkun O, 2013, CURR PHARM DESIGN, V19, P4806, DOI 10.2174/1381612811319270003
   Jamieson KL, 2017, PHARMACOL THERAPEUT, V179, P47, DOI 10.1016/j.pharmthera.2017.05.005
   Lamounier-Zepter V, 2015, INT J OBESITY, V39, P755, DOI 10.1038/ijo.2014.193
   Lu JL, 2016, LANCET DIABETES ENDO, V4, P470, DOI 10.1016/S2213-8587(16)30007-9
   Masuda Y, 2016, J PHARMACOL SCI, V132, P271, DOI 10.1016/j.jphs.2016.11.001
   Moulana M, 2014, PHYSIOL REP, V2, DOI 10.14814/phy2.12022
   Murphy E, 2016, CIRC RES, V118, P1960, DOI 10.1161/RES.0000000000000104
   Otterbein LE, 2016, CIRC RES, V118, P1940, DOI 10.1161/CIRCRESAHA.116.306588
   Sacerdoti D, 2016, PROSTAG OTH LIPID M, V125, P65, DOI 10.1016/j.prostaglandins.2016.06.002
   Sanders WG, 2012, AM J PHYSIOL-CELL PH, V303, pC278, DOI 10.1152/ajpcell.00386.2011
   Santilli F, 2017, CURR MED CHEM, V24, P2602, DOI 10.2174/0929867324666170710121145
   Shinoda Y, 2016, J PHARMACOL SCI, V131, P172, DOI 10.1016/j.jphs.2016.05.012
   Song MS, 2017, CELL METAB, V26, P872, DOI 10.1016/j.cmet.2017.09.023
   Tappy L, 2010, PHYSIOL REV, V90, P23, DOI 10.1152/physrev.00019.2009
   Yanagihara H, 2016, J PHARMACOL SCI, V131, P190, DOI 10.1016/j.jphs.2016.06.003
   Zhao YZ, 2015, J PHARMACOL SCI, V129, P83, DOI 10.1016/j.jphs.2015.09.002
NR 31
TC 13
Z9 16
U1 0
U2 3
PU JAPANESE PHARMACOLOGICAL SOC
PI KYOTO
PA EDITORIAL OFF, KANTOHYA BLDG GOKOMACHI-EBISUGAWA NAKAGYO-KU, KYOTO, 604,
   JAPAN
SN 1347-8613
EI 1347-8648
J9 J PHARMACOL SCI
JI J. Pharmacol. Sci.
PD OCT
PY 2018
VL 138
IS 2
BP 138
EP 145
DI 10.1016/j.jphs.2018.09.010
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HA7GM
UT WOS:000450449300007
PM 30342783
OA gold
DA 2025-06-11
ER

PT J
AU Walburg, FS
   van Meijel, B
   Hoekstra, T
   Kol, J
   Pape, LM
   de Joode, JW
   van Tulder, M
   Adriaanse, M
AF Walburg, Florine Sanna
   van Meijel, Berno
   Hoekstra, Trynke
   Kol, Jelle
   Pape, Laura Michelle
   de Joode, Johanna Willemina
   van Tulder, Maurits
   Adriaanse, Marcel
TI Effectiveness of a Lifestyle Intervention for People With a Severe
   Mental Illness in Dutch Outpatient Mental Health Care A Randomized
   Clinical Trial
SO JAMA PSYCHIATRY
LA English
DT Article
ID WEIGHT-LOSS; SCHIZOPHRENIA; RISK; DISORDERS; DIET
AB IMPORTANCE People with a severe mental illness (SMI) have a life expectancy reduced by 10 to 20 years compared with the general population, primarily attributable to cardiometabolic disorders. Lifestyle interventions for people with SMI can improve health and reduce cardiometabolic risk.
   OBJECTIVE To evaluate the effectiveness of a group-based lifestyle intervention among people with SMI in outpatient treatment settings compared with treatment as usual (TAU).
   DESIGN, SETTING, AND PARTICIPANTS The Severe Mental Illness Lifestyle Evaluation (SMILE) study is a pragmatic cluster randomized clinical trial performed in 8 mental health care centers with 21 flexible assertive community treatment teams in the Netherlands. Inclusion criteria were SMI, age of 18 years or older, and body mass index (calculated as weight in kilograms divided by height in meters squared) of 27 or greater. Data were collected from January 2018 to February 2020, and data were analyzed from September 2020 to February 2023.
   INTERVENTIONS Weekly 2-hour group sessions for 6 months followed by monthly 2-hour group sessions for another 6 months, delivered by trained mental health care workers. The intervention targeted overall lifestyle changes, emphasizing establishing a healthy diet and promoting physical activity. TAU (control) did not include structured interventions or advice on lifestyle.
   MAIN OUTCOMES AND MEASURES Crude and adjusted linear mixed models and multivariable logistic regression analyses were performed. The main outcome was body weight change. Secondary outcomes included changes in body mass index, blood pressure, lipid profiles, fasting glucose level, quality of life, self-management ability, and lifestyle behaviors (physical activity and health, mental health, nutrition, and sleep).
   RESULTS The study population included 11 lifestyle intervention teams (126 participants) and 10 TAU teams (98 participants). Of 224 included patients, 137 (61.2%) were female, and the mean (SD) age was 47.6 (11.1) years. From baseline to 12 months, participants in the lifestyle intervention group lost 3.3 kg (95% CI, -6.2 to -0.4) more than those in the control group. In the lifestyle intervention group, people with high attendance rates lost more weight than participants with medium and low rates (mean [SD] weight loss: high, -4.9 [8.1] kg; medium, -0.2 [7.8] kg; low, 0.8 [8.3] kg). Only small or no changes were found for secondary outcomes.
   CONCLUSIONS AND RELEVANCE In this trial, the lifestyle intervention significantly reduced weight from baseline to 12 months in overweight and obese adults with SMI. Tailoring lifestyle interventions and increasing attendance rates might be beneficial for people with SMI.
C1 [Walburg, Florine Sanna; Hoekstra, Trynke; Kol, Jelle; Pape, Laura Michelle; de Joode, Johanna Willemina; Adriaanse, Marcel] Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Dept Hlth Sci, Amsterdam, Netherlands.
   [van Meijel, Berno] Inholland Univ Appl Sci, Dept Hlth Sports & Welfare, Mental Hlth Nursing Res Grp, Amsterdam, Netherlands.
   [van Meijel, Berno] Amsterdam UMC VUmc, Dept Psychiat, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands.
   [van Meijel, Berno] Parnassia Acad, Parnassia Psychiat Inst, The Hague, Netherlands.
   [van Tulder, Maurits] Vrije Univ Amsterdam, Fac Behav & Movement Sci, Dept Clin Neuro & Dev Psychol, Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; Parnassia
   Psychiatric Institute; Vrije Universiteit Amsterdam
RP Walburg, FS (corresponding author), Vrije Univ Amsterdam, Dept Hlth Sci, Amsterdam Publ Hlth Res Inst, De Boelelaan 1105, NL-1081 HV Amsterdam, Netherlands.
EM florine.walburg@vu.nl
RI Hoekstra, Trynke/AAG-5901-2020; van Tulder, Maurits/AAB-9785-2022;
   Adriaanse, Marieke/AFQ-8371-2022
OI Walburg, F.S./0000-0002-4079-1500; van Tulder,
   Maurits/0000-0002-7589-8471; Adriaanse, Marcel/0000-0002-5085-6662;
   Hoekstra, Trynke/0000-0002-0535-0056
FU Netherlands Organization for Health Research and Development (ZonMW)
   [80-84300-98-72012]
FX This study was funded by grant 80-84300-98-72012 from the Netherlands
   Organization for Health Research and Development (ZonMW).
CR Andreassen OA, 2013, AM J HUM GENET, V92, P197, DOI 10.1016/j.ajhg.2013.01.001
   Appel LJ, 2003, JAMA-J AM MED ASSOC, V289, P2083, DOI 10.1001/jama.289.16.2083
   Bradshaw T, 2014, HEALTHCARE, V2, P166, DOI 10.3390/healthcare2020166
   Burke B., 2002, Motivational interviewing: Preparing people for change, V2nd, P217
   Correll CU, 2015, WORLD PSYCHIATRY, V14, P119, DOI 10.1002/wps.20204
   de Boer MR, 2015, INT J BEHAV NUTR PHY, V12, DOI 10.1186/s12966-015-0162-z
   de Mooij LD, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00855
   Engbers LH, 2005, AM J PREV MED, V29, P61, DOI 10.1016/j.amepre.2005.03.001
   Fernández-Abascal B, 2021, NEUROSCI BIOBEHAV R, V125, P535, DOI 10.1016/j.neubiorev.2021.01.005
   Firth J, 2019, LANCET PSYCHIAT, V6, P675, DOI 10.1016/S2215-0366(19)30132-4
   Green CA, 2015, AM J PSYCHIAT, V172, P71, DOI 10.1176/appi.ajp.2014.14020173
   Hjorthoj C, 2017, LANCET PSYCHIAT, V4, P295, DOI 10.1016/S2215-0366(17)30078-0
   John A, 2018, SCHIZOPHR RES, V199, P154, DOI 10.1016/j.schres.2018.04.009
   Kamphuis CBM, 2018, INT J EQUITY HEALTH, V17, DOI 10.1186/s12939-018-0884-z
   Laursen TM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0067133
   Laursen TM, 2011, J PSYCHIATR RES, V45, P29, DOI 10.1016/j.jpsychires.2010.04.027
   Liu YF, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0203127
   Looijmans A, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/s12888-014-0293-9
   Mackenbach JP, 2016, BMJ-BRIT MED J, V353, DOI 10.1136/bmj.i1732
   Marmot M, 2012, LANCET, V380, P1011, DOI 10.1016/S0140-6736(12)61228-8
   McCreadie RG, 2003, BRIT J PSYCHIAT, V183, P534, DOI 10.1192/bjp.183.6.534
   McGaghie WC., 1974, SELF DIRECTED BEHAV
   Naslund JA, 2017, GEN HOSP PSYCHIAT, V47, P83, DOI 10.1016/j.genhosppsych.2017.04.003
   Nielsen RE, 2021, NAT REV CARDIOL, V18, P136, DOI 10.1038/s41569-020-00463-7
   Nugter MA, 2016, COMMUNITY MENT HLT J, V52, P898, DOI 10.1007/s10597-015-9831-2
   Pape LM, 2022, BMC PSYCHIATRY, V22, DOI 10.1186/s12888-022-03854-x
   Prochaska JO, 1997, AM J HEALTH PROMOT, V12, P38, DOI 10.4278/0890-1171-12.1.38
   Rademakers J, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-577
   Ringen PA, 2018, NORD J PSYCHIAT, V72, P296, DOI 10.1080/08039488.2018.1449012
   Rollnick S., 1999, Health Behavior Change: A Guide for Practitioners
   Rollnick S., 1995, BEHAV COGN PSYCHOTH, V23, P325, DOI [DOI 10.1017/S135246580001643X, 10.1017/S135246580001643X]
   Speyer H, 2019, PSYCHOTHER PSYCHOSOM, V88, P350, DOI 10.1159/000502293
   Swinburn B, 1999, PREV MED, V29, P563, DOI 10.1006/pmed.1999.0585
   Twisk J, 2018, CONT CLIN TRIAL COMM, V10, P80, DOI 10.1016/j.conctc.2018.03.008
   Twisk JWR, 2013, APPLIED LONGITUDINAL DATA ANALYSIS FOR EPIDEMIOLOGY: A PRACTICAL GUIDE, 2ND EDITION, P1
   Walburg F, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0271990
   Walburg FS, 2022, BMC HEALTH SERV RES, V22, DOI 10.1186/s12913-021-07391-3
   Walburg FS, 2019, BMC PSYCHIATRY, V19, DOI 10.1186/s12888-019-2132-5
   Walker ER, 2015, JAMA PSYCHIAT, V72, P334, DOI 10.1001/jamapsychiatry.2014.2502
   Ware JE, 1996, MED CARE, V34, P220, DOI 10.1097/00005650-199603000-00003
   Yarborough BJHYM., 2013, FACILITATOR GUIDE ST
   Yarborough BJH, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-238
NR 42
TC 11
Z9 11
U1 0
U2 7
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-622X
EI 2168-6238
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD SEP
PY 2023
VL 80
IS 9
BP 886
EP 894
DI 10.1001/jamapsychiatry.2023.1566
EA JUN 2023
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA W8MO9
UT WOS:001020073300003
PM 37342055
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Bogale, SK
   Sarma, H
   Gray, D
   Kelly, M
AF Bogale, Sitotaw Kerie
   Sarma, Haribondhu
   Gray, Darren
   Kelly, Matthew
TI The effectiveness, feasibility, and acceptability of an education
   intervention promoting healthy lifestyle to reduce risk factors for
   metabolic syndrome, among office workers in Ethiopia: A protocol for a
   randomized control trial study
SO PLOS ONE
LA English
DT Article
ID PREVALENCE
AB Background Nowadays, metabolic syndrome has become a major health threat, and affects over one billion people globally. It also plays a great role in the growth of diseases like type 2 diabetes, coronary diseases, stroke, and other chronicity. It increases the risk of cardiovascular disorder and stroke by three to ten times and diabetic mellitus by ten times. The prevalence of metabolic syndrome is increasing globally as a result of epidemiological shift. Low and middle-income countries are facing an increasing burden of metabolic syndrome. There is a need for concerted efforts to modify behavioral risk factors that significantly contribute to the prevalence of the syndrome. This can be done by developing and implementing appropriate interventions that can bring behavior change after testing for effectiveness, feasibility, and acceptability. Thus, this study aims to develop and test the effectiveness, feasibility and acceptability of an education intervention promoting healthy lifestyle to reduce risk factors for metabolic syndrome, among office workers in Ethiopia.Methods and analysis This randomized controlled trial will be implemented with 226 bank employees (age >= 18 years) with metabolic syndrome from government and private banks in Bahir Dar City, Ethiopia. Participants will be randomized to intervention (education) and control (general health advice) groups. The intervention group will be given one-on -one base education about healthy diets, physical exercise, stress management, avoidance of harmful alcohol consumption and smoking cessation by experts on health promotion. Text messages will be sent every two weeks and reading materials will also be provided. Additionally, a review meeting will be held at the 3rd and 6th month of the intervention. The primary outcomes of interest will be change in metabolic parameters (obesity levels, blood pressure, fasting blood glucose, total cholesterol, high density lipoprotein, low density lipoprotein, and triglycerides). Secondary outcomes will be knowledge, attitudes and practice of the participants towards lifestyle and cardiovascular risk factors, feasibility, acceptability, implementation fidelity, and cost-effectiveness of the intervention. Data will be collected at three time points: at baseline, at the 6th month of the intervention and at the end of the intervention (9 months). Generalized linear mixed models will be utilized to compare the desired outcome between the trial arms, after accounting for baseline variations. Cost-benefit analysis and a qualitative process evaluation of the intervention will also be conducted.Discussion This randomized control trial study will provide information on the effectiveness, feasibility, and acceptability of an education intervention promoting healthy lifestyle to reduce risk factors for metabolic syndrome, among office workers in Ethiopia, where the burden of metabolic syndrome is high among office workers.Clinical trial registration This trial has been prospectively registered at the Australian New Zealand Clinical Trials Registry: ACTRN12623000409673p.
C1 [Bogale, Sitotaw Kerie; Sarma, Haribondhu; Gray, Darren; Kelly, Matthew] Australian Natl Univ, Natl Ctr Epidemiol & Populat Hlth, Canberra, ACT, Australia.
   [Bogale, Sitotaw Kerie] Bahir Dar Univ, Coll Med & Hlth Sci, Bahir Dar, Ethiopia.
   [Gray, Darren] QIMR Berghofer Med Res Inst, Populat Hlth Program, Brisbane, Australia.
C3 Australian National University; Bahir Dar University; QIMR Berghofer
   Medical Research Institute
RP Bogale, SK (corresponding author), Australian Natl Univ, Natl Ctr Epidemiol & Populat Hlth, Canberra, ACT, Australia.; Bogale, SK (corresponding author), Bahir Dar Univ, Coll Med & Hlth Sci, Bahir Dar, Ethiopia.
EM Sitotaw.Bogale@anu.edu.au
RI Sarma, Haribondhu/AAG-4817-2020; Kelly, Matthew/ABC-1069-2020
OI Sarma, Haribondhu/0000-0003-1553-8498; Kelly,
   Matthew/0000-0001-7963-2139
FX We express our gratitude to every research participant who will be
   working with us on this project. We also want to express our gratitude
   to the bank managers for granting us permission to collect data in their
   respective bank branches.
CR Abdi J, 2015, J RES HEALTH SCI, V15, P256
   Adogu P., 2015, Am J Med Med Sci, V5, P150, DOI [10.5923/j.ajmms.20150504.02, DOI 10.5923/J.AJMMS.20150504.02]
   Alemayehu AM, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0251777
   Amarasekara P, 2016, ASIA-PAC J PUBLIC HE, V28, p32S, DOI 10.1177/1010539515612123
   Ambachew S, 2020, J OBES, V2020, DOI 10.1155/2020/2701309
   Carroll C, 2007, IMPLEMENT SCI, V2, DOI 10.1186/1748-5908-2-40
   Cleghorn CL, 2016, PUBLIC HEALTH NUTR, V19, P2915, DOI 10.1017/S1368980016001099
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Crotteau M.A., 2020, Pilot Project: Developing a Standardized Evidence-Based Education Process for Nurses to Enhance New Medication Eduction of Hospitalized Patients with Heart Failure
   Damschroder LJ, 2009, IMPLEMENT SCI, V4, DOI 10.1186/1748-5908-4-50
   Dejenie M, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0252298
   Detection N.C.E.P.E.P.o., 2002, The Program
   Fort MP, 2015, BMC HEALTH SERV RES, V15, DOI 10.1186/s12913-015-1248-7
   Gebremariam LW, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-27519-6
   Jamal SN, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0160343
   Juma K., 2019, Public Health in Developing Countries-Challenges and Opportunities, P31, DOI 10.5772/intechopen.89507
   Kassahun CW, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0170040
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Kerie S, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0210969
   Marangos PJ., 2010, Handbook of disease burdens and quality of life measures, P1135
   Misra A, 2008, J CLIN ENDOCR METAB, V93, pS9, DOI 10.1210/jc.2008-1595
   Mohan V., 2006, DIABETES VOICE, V51
   Motuma A, 2020, DIABET METAB SYND OB, V13, P4941, DOI 10.2147/DMSO.S283270
   Negesa LB, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0234198
   Nestel P, 2007, ASIA PAC J CLIN NUTR, V16, P362
   Nuriddin T., A Selected Focus on Sub-Saharan Africa
   Okafor Christian I, 2012, Indian J Endocrinol Metab, V16, P56, DOI 10.4103/2230-8210.91191
   Padam S., 2012, J Clin Prev Cardiol, V1, P88
   Palmer S., 1997, Handbook of counselling
   Proctor E, 2011, ADM POLICY MENT HLTH, V38, P65, DOI 10.1007/s10488-010-0319-7
   Pyykkönen AJ, 2010, DIABETES CARE, V33, P378, DOI 10.2337/dc09-1027
   Ramic Enisa, 2016, Mater Sociomed, V28, P71, DOI 10.5455/msm.2016.28.71-73
   Saffari M, 2013, IRAN J PUBLIC HEALTH, V42, P172
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Samerchua W., Knowledge, Attitude, and Practice Toward Metabolic Syndrome Prevention Among Buddhist Monks in Nan Province
   Scholze J, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-529
   Shitu K, 2021, INT J HYPERTENS, V2021, DOI 10.1155/2021/6616473
   Sinaga M., 2020, Effect of Behaviour Change Communication on Metabolic Syndrome and Its Markers among Ethiopian Adults: Randomized Controlled Trial
   Tran A, 2011, INT J HYPERTENS, V2011, DOI 10.4061/2011/193719
   Verma A, 2019, J FAM MED PRIM CARE, V8, P178, DOI 10.4103/jfmpc.jfmpc_257_18
   Weiner BJ, 2017, IMPLEMENT SCI, V12, DOI 10.1186/s13012-017-0635-3
   Kassahun CW, 2020, INT J HYPERTENS, V2020, DOI 10.1155/2020/5649165
NR 42
TC 0
Z9 0
U1 1
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 30
PY 2024
VL 19
IS 8
AR e0307659
DI 10.1371/journal.pone.0307659
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA E6O1P
UT WOS:001304170300003
PM 39213318
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU de Kock, A
   Malan, L
   Potgieter, JC
   Steenekamp, W
   van der Merwe, MT
AF de Kock, A.
   Malan, L.
   Potgieter, J. C.
   Steenekamp, W.
   van der Merwe, M. T.
TI Metabolic Syndrome Indicators and Target Organ Damage in Urban Active
   Coping African and Caucasian Men: The SABPA Study
SO EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
LA English
DT Article
DE coping; endothelial dysfunction; ethnicity; metabolic syndrome
ID STRATEGY INDICATOR; BLOOD-GLUCOSE; DISEASE; RISK; URBANIZATION;
   HYPERTENSION; MORTALITY; THUSA
AB Psychosocial stress relating to an urban environment or acculturation increases the prevalence of metabolic syndrome (MetS). The objectives of this study were firstly to indicate and compare differences regarding appraisal of stress or active coping responses in urban African (n=88) and Caucasian (n=101) male teachers of South Africa, in accord with the prevalence of MetS indicators. And secondly to investigate the extent to which utilisation of active coping responses, together with MetS indicators, predict target organ damage, in these men. The Coping Strategy Indicator determined high and low active coping responses in male teachers from the Sympathetic Activity and Ambulatory Blood Pressure in Africans (SABPA) study. SABPA inclusion and exclusion criteria were used. Additionally, diabetic medication users (n=8), and participants with renal impairment (n=2) or HIV positive (n=13), were excluded. MetS indicators included glucose, triglyceride, high-density lipoprotein cholesterol, blood pressure, and waist circumference, independent of confounders (age, physical activity, gamma glutamyl transferase). Microalbuminuria and carotid intima-media thickness indicated target organ damage. More MetS indicators exceeded the IDF cut-off points in high active coping African men (14.71%) than in their Caucasian counterparts (3.33%), as determined from X-2 analyses. Furthermore, stepwise regressions indicated that more MetS indicators predicted endothelial dysfunction, especially in the high active coping African men. High active coping African men showed more manifestation of MetS, compared to their Caucasian counterparts, and revealed progress towards endothelial dysfunction.
C1 [Potgieter, J. C.] Univ Pretoria, North West Univ, Sch Psychosocial Behav Sci, ZA-0002 Pretoria, South Africa.
   [van der Merwe, M. T.] Univ Pretoria, Bariatr Ctr Excellence, ZA-0002 Pretoria, South Africa.
   [de Kock, A.; Malan, L.] Univ Pretoria, Sch Physiol Nutr & Consumer Sci, Hypertens Africa Res Team HART, ZA-0002 Pretoria, South Africa.
C3 North West University - South Africa; University of Pretoria; University
   of Pretoria; University of Pretoria
RP Malan, L (corresponding author), North West Univ, Private Bag X6001, ZA-2520 Potchefstroom, South Africa.
EM 10060871@nwu.ac.za
RI Malan, Leone/Q-8187-2019; Malan, Leone/D-7203-2014
OI Malan, Leone/0000-0003-3187-2410
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   AMIRKHAN JH, 1990, J PERS SOC PSYCHOL, V59, P1066, DOI 10.1037/0022-3514.59.5.1066
   AMIRKHAN JH, 1994, J PERS ASSESS, V62, P242, DOI 10.1207/s15327752jpa6202_6
   [Anonymous], 2007, VASC HLTH RISK MANAG, V3, P783
   [Anonymous], 2008, ETH PRINC MED RES IN
   Budoff MJ, 2006, ATHEROSCLEROSIS, V187, P343, DOI 10.1016/j.atherosclerosis.2005.09.013
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Danaei G, 2006, LANCET, V368, P1651, DOI 10.1016/S0140-6736(06)69700-6
   Desmond DM, 2006, PERS INDIV DIFFER, V40, P249, DOI 10.1016/j.paid.2005.04.015
   Dressler WW, 1996, SEMIN NEPHROL, V16, P71
   Gaillard T, 2010, CURR CARDIOVASC RISK, V4, P186, DOI 10.1007/s12170-010-0092-x
   KOHARA K, 1995, HYPERTENSION, V26, P808, DOI 10.1161/01.HYP.26.5.808
   Malan L, 2006, INT J PSYCHOPHYSIOL, V61, P158, DOI 10.1016/j.ijpsycho.2005.07.015
   Malan L, 2008, BIOL PSYCHOL, V79, P323, DOI 10.1016/j.biopsycho.2008.07.007
   Meijer R, 2010, CEREBROVASC DIS, V30, P448, DOI 10.1159/000319572
   Norman R, 2007, SAMJ S AFR MED J, V97, P708
   Ntyintyane L, 2009, METAB SYNDR RELAT D, V7, P243, DOI 10.1089/met.2008.0080
   Okpechi Ikechi G, 2007, Diab Vasc Dis Res, V4, P365, DOI 10.3132/dvdr.2007.066
   Oosthuizen W, 2002, SAMJ S AFR MED J, V92, P723
   Port SC, 2005, AM HEART J, V150, P209, DOI 10.1016/j.ahj.2004.09.031
   Ross E, 2004, PSYCHOSOCIAL APPROAC, P18
   Seedat YK, 2009, CARDIOVASC J AFR, V20, P39
   Stapelberg R, 1999, THESIS POTCHEFSTROOM
   Statsoft Inc, 2011, 2011 STATISTICA WIND
   Suzuki S, 2003, INT J PSYCHOPHYSIOL, V47, P117, DOI 10.1016/S0167-8760(02)00120-4
   Watson Karol E, 2004, Rev Cardiovasc Med, V5 Suppl 3, pS14
   World Health Organization, 2003, GLOB PHYS ACT QUEST
NR 27
TC 4
Z9 4
U1 0
U2 5
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0947-7349
J9 EXP CLIN ENDOCR DIAB
JI Exp. Clin. Endocrinol. Diabet.
PD MAY
PY 2012
VL 120
IS 5
BP 282
EP 287
DI 10.1055/s-0031-1295472
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA 966UF
UT WOS:000305862200008
PM 22231925
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Ando, H
   Takamura, T
   Matsuzawa-Nagata, N
   Shima, KR
   Nakamura, S
   Kumazaki, M
   Kurita, S
   Misu, H
   Togawa, N
   Fukushima, T
   Fujimura, A
   Kaneko, S
AF Ando, Hitoshi
   Takamura, Toshinari
   Matsuzawa-Nagata, Naoto
   Shima, Kosuke R.
   Nakamura, Seiji
   Kumazaki, Masafumi
   Kurita, Seiichiro
   Misu, Hirofumi
   Togawa, Naoyuki
   Fukushima, Tatsunobu
   Fujimura, Akio
   Kaneko, Shuichi
TI The hepatic circadian clock is preserved in a lipid-induced mouse model
   of non-alcoholic steatohepatitis
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Atherogenic diet; Circadian rhythm; Clock gene; Non-alcoholic
   steatohepatitis; Oxidative stress
ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; NECROSIS-FACTOR-ALPHA; HEPATOCYTE
   CELL-LINE; FATTY LIVER-DISEASE; DIETARY RAT MODEL; GENE-EXPRESSION;
   OXIDATIVE STRESS; RECEPTOR EXPRESSION; PERIPHERAL-TISSUES; METABOLIC
   SYNDROME
AB Recent studies have correlated metabolic diseases, such as metabolic syndrome and non-alcoholic fatty liver disease, with the circadian clock. However, whether such metabolic changes per se affect the circadian clock remains controversial. To address this, we investigated the daily mRNA expression profiles of clock genes in the liver of a dietary mouse model of non-alcoholic steatohepatitis (NASH) using a custom-made, high-precision DNA chip. C57BL/6J mice fed an atherogenic diet for 5 weeks developed hypercholesterolemia, oxidative stress, and NASH. DNA chip analyses revealed that the atherogenic diet had a great influence on the mRNA expression of a wide range of genes linked to mitochondrial energy production, redox regulation, and carbohydrate and lipid metabolism. However, the rhythmic mRNA expression of the clock genes in the liver remained intact. Most of the circadianly expressed genes also showed 24-h rhythmicity. These findings Suggest that the biological clock is protected against such a metabolic derangement as NASH. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Ando, Hitoshi; Takamura, Toshinari; Matsuzawa-Nagata, Naoto; Shima, Kosuke R.; Nakamura, Seiji; Kumazaki, Masafumi; Kurita, Seiichiro; Misu, Hirofumi; Kaneko, Shuichi] Kanazawa Univ, Grad Sch Med Sci, Dept Dis Control & Homeostasis, Kanazawa, Ishikawa 9208641, Japan.
   [Fujimura, Akio] Jichi Med Univ, Sch Med, Dept Pharmacol, Div Clin Pharmacol, Shimotsuke, Tochigi 3290498, Japan.
   [Togawa, Naoyuki; Fukushima, Tatsunobu] Mitsubishi Rayon Co Ltd, Yokohama Res Labs, Kanagawa 2300053, Japan.
C3 Kanazawa University; Jichi Medical University; Mitsubishi International
   Corporation (MIC); Mitsubishi Chemical Holdings Corporation; Mitsubishi
   Rayon Co., Ltd.
RP Takamura, T (corresponding author), Kanazawa Univ, Grad Sch Med Sci, Dept Dis Control & Homeostasis, 13-1 Takara Machi, Kanazawa, Ishikawa 9208641, Japan.
EM ttakamura@m-kanazawa.jp
RI ANDO, Hitoshi/O-8199-2016; Nagata, Naoto/D-9261-2012
OI Nagata, Naoto/0000-0002-2389-2334; Togawa, Naoyuki/0000-0002-4650-4736
FU Ministry of Education, Culture, Sports, Science and Technology, Japan
FX This work was supported by in part of a Grant-in-Aid for Scientific
   Research from the Ministry of Education, Culture, Sports, Science and
   Technology, Japan.
CR Ando H, 2005, ENDOCRINOLOGY, V146, P5631, DOI 10.1210/en.2005-0771
   Ando H, 2009, DIABETOLOGIA, V52, P329, DOI 10.1007/s00125-008-1194-6
   ANDO H, CLIN EXP HY IN PRESS
   Ando H, 2006, BIOCHEM BIOPH RES CO, V346, P1297, DOI 10.1016/j.bbrc.2006.06.044
   Busino L, 2007, SCIENCE, V316, P900, DOI 10.1126/science.1141194
   Farrell GC, 2006, HEPATOLOGY, V43, pS99, DOI 10.1002/hep.20973
   Fu LN, 2002, CELL, V111, P41, DOI 10.1016/S0092-8674(02)00961-3
   Gatfield D, 2007, SCIENCE, V316, P1135, DOI 10.1126/science.1144165
   Hardeland R, 2003, CHRONOBIOL INT, V20, P921, DOI 10.1081/CBI-120025245
   Hirota T, 2002, J BIOL CHEM, V277, P44244, DOI 10.1074/jbc.M206233200
   Kohsaka A, 2007, CELL METAB, V6, P414, DOI 10.1016/j.cmet.2007.09.006
   Kudo T, 2004, DIABETOLOGIA, V47, P1425, DOI 10.1007/s00125-004-1461-0
   Kurita S, 2008, EUR J PHARMACOL, V588, P316, DOI 10.1016/j.ejphar.2008.04.028
   Langmesser S, 2006, CHRONOBIOL INT, V23, P151, DOI 10.1080/07420520500464437
   Lowrey PL, 2004, ANNU REV GENOM HUM G, V5, P407, DOI 10.1146/annurev.genom.5.061903.175925
   Matsuzawa N, 2007, HEPATOLOGY, V46, P1392, DOI 10.1002/hep.21874
   Matsuzawa-Nagata N, 2008, METABOLISM, V57, P1071, DOI 10.1016/j.metabol.2008.03.010
   Misu H, 2007, DIABETOLOGIA, V50, P268, DOI 10.1007/s00125-006-0489-8
   Obrietan K, 1998, NAT NEUROSCI, V1, P693, DOI 10.1038/3695
   Oishi K, 2004, BIOCHEM BIOPH RES CO, V317, P330, DOI 10.1016/j.bbrc.2004.03.055
   Reppert SM, 2002, NATURE, V418, P935, DOI 10.1038/nature00965
   Rutter J, 2001, SCIENCE, V293, P510, DOI 10.1126/science.1060698
   Scott EM, 2008, INT J OBESITY, V32, P658, DOI 10.1038/sj.ijo.0803778
   Shimizu A, 2007, METABOLISM, V56, P1478, DOI 10.1016/j.metabol.2007.06.013
   Sookoian S, 2007, WORLD J GASTROENTERO, V13, P4242, DOI 10.3748/wjg.v13.i31.4242
   Takamura T, 2004, DIABETOLOGIA, V47, P638, DOI 10.1007/s00125-004-1366-y
   TAKAMURA T, OBESITY IN PRESS
   Takamura T, 2008, CURR PHARM BIOTECHNO, V9, P392, DOI 10.2174/138920108785915184
   Takeshita Y, 2006, METABOLISM, V55, P1464, DOI 10.1016/j.metabol.2006.06.016
   Takeshita Y, 2008, EUR J PHARMACOL, V579, P426, DOI 10.1016/j.ejphar.2007.11.016
   Turek FW, 2005, SCIENCE, V308, P1043, DOI 10.1126/science.1108750
   Uno M, 2008, HEPATOLOGY, V48, P109, DOI 10.1002/hep.22338
   Woon PY, 2007, P NATL ACAD SCI USA, V104, P14412, DOI 10.1073/pnas.0703247104
   Yanagihara H, 2006, CHRONOBIOL INT, V23, P905, DOI 10.1080/07420520600827103
   Yang XY, 2006, CELL, V126, P801, DOI 10.1016/j.cell.2006.06.050
   Yoo SH, 2004, P NATL ACAD SCI USA, V101, P5339, DOI 10.1073/pnas.0308709101
NR 36
TC 24
Z9 26
U1 1
U2 8
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD MAR 13
PY 2009
VL 380
IS 3
BP 684
EP 688
DI 10.1016/j.bbrc.2009.01.150
PG 5
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 419LZ
UT WOS:000264222400046
PM 19285022
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Garcia-Serrano, AM
   Mohr, AA
   Philippe, J
   Skoug, C
   Spégel, P
   Duarte, JMN
AF Garcia-Serrano, Alba M.
   Mohr, Adelaide A.
   Philippe, Juliette
   Skoug, Cecilia
   Spegel, Peter
   Duarte, Joao M. N.
TI Cognitive Impairment and Metabolite Profile Alterations in the
   Hippocampus and Cortex of Male and Female Mice Exposed to a Fat and
   Sugar-Rich Diet are Normalized by Diet Reversal
SO AGING AND DISEASE
LA English
DT Article
DE brain metabolism; memory; anxiety; obesity; diabetes; sucrose; high-fat
ID IN-VIVO; NEUROCHEMICAL MODIFICATIONS; N-ACETYLASPARTATE; BRAIN; OBESITY;
   NEUROGENESIS; INFLAMMATION; RATS; CNS
AB Diabetes impacts on brain metabolism, structure, and function. Alterations in brain metabolism have been observed in obesity and diabetes models induced by exposure to diets rich in saturated fat and/or sugar and have been linked to memory impairment. However, it remains to be determined whether brain dysfunction induced by obesogenic diets results from permanent brain alterations. We tested the hypothesis that an obesogenic diet (high-fat and high-sucrose diet; HFHSD) causes reversible changes in hippocampus and cortex metabolism and alterations in behavior. Mice were exposed to HFHSD for 24 weeks or for 16 weeks followed by 8 weeks of diet normalization. Development of the metabolic syndrome, changes in behavior, and brain metabolite profiles by magnetic resonance spectroscopy (MRS) were assessed longitudinally. Control mice were fed an ingredient-matched low-fat and low-sugar diet. Mice fed the HFHSD developed obesity, glucose intolerance and insulin resistance, with a more severe phenotype in male than female mice. Relative to controls, both male and female HFHSD-fed mice showed increased anxiety-like behavior, impaired memory in object recognition tasks, but preserved working spatial memory as evaluated by spontaneous alternation in a Y-maze. Alterations in the metabolite profiles were observed both in the hippocampus and cortex but were more distinct in the hippocampus. HFHSD-induced metabolic changes included altered levels of lactate, glutamate, GABA, glutathione, taurine, N-acetylaspartate, total creatine and total choline. Notably, HFHSD-induced metabolic syndrome, anxiety, memory impairment, and brain metabolic alterations recovered upon diet normalization for 8 weeks. In conclusion, cortical and hippocampal derangements induced by long-term HFHSD consumption are reversible rather than being the result of permanent tissue damage.
C1 [Garcia-Serrano, Alba M.; Philippe, Juliette; Skoug, Cecilia; Duarte, Joao M. N.] Lund Univ, Fac Med, Dept Expt Med Sci, Lund, Sweden.
   [Garcia-Serrano, Alba M.; Philippe, Juliette; Skoug, Cecilia; Duarte, Joao M. N.] Lund Univ, Wallenberg Ctr Mol Med, Lund, Sweden.
   [Mohr, Adelaide A.] Ecole Polytech Fed Lausanne EPFL, Inst Phys, Sch Basic Sci, Lausanne, Switzerland.
   [Spegel, Peter] Lund Univ, Ctr Anal & Synth, Dept Chem, Lund, Sweden.
C3 Lund University; Lund University; Swiss Federal Institutes of Technology
   Domain; Ecole Polytechnique Federale de Lausanne; Lund University
RP Duarte, JMN (corresponding author), Lund Univ, Fac Med, Dept Expt Med Sci, Lund, Sweden.
EM joao.duarte@med.lu.se
RI Spégel, Peter/G-9947-2018; Garcia-Serrano, Alba/U-5101-2019; Skoug,
   Cecilia/KCY-7907-2024; Duarte, Joao/H-4887-2012
OI Skoug, Cecilia/0000-0002-4999-1939; Duarte, Joao/0000-0001-5984-1574;
   Mohr, Adelaide/0000-0002-1085-7636
FU Swedish Research Council [2019-01130]; Crafoord Foundation;
   Diabetesfonden [Dia2019-440]; Direktor Albert Pahlssons stiftelse;
   Demensfonden; Royal Physiographic Society of Lund; Stiftelsen Lars
   Hiertas Minne; Swedish foundation for International Cooperation in
   Research and Higher Education [BR2019-8508]; Young IBRO Regions
   Connecting Award; Knut and Alice Wallenberg foundation; Medical Faculty
   at Lund University; Region Skane; Lund University Diabetes Centre -
   Swedish Research Council (Strategic Research Area EXODIAB) [2009-1039];
   Swedish Foundation for Strategic Research [IRC15-0067]; Swedish Research
   Council [2019-01130] Funding Source: Swedish Research Council
FX This work was funded by the Swedish Research Council (2019-01130) ,
   Crafoord Foundation, Diabetesfonden (Dia2019-440) , Direktor Albert
   Pahlssons stiftelse, Demensfonden, Royal Physiographic Society of Lund,
   Stiftelsen Lars Hiertas Minne, Swedish foundation for International
   Cooperation in Research and Higher Education (BR2019-8508) , and Young
   IBRO Regions Connecting Award. The Knut and Alice Wallenberg foundation,
   the Medical Faculty at Lund University and Region Skane are acknowledged
   for generous financial support to JMND. The authors acknowledge support
   from Lund University Diabetes Centre, which is funded by the Swedish
   Research Council (Strategic Research Area EXODIAB, grant 2009-1039) and
   Swedish Foundation for Strategic Research (grant IRC15-0067) .
CR Albrecht J, 2005, NEUROCHEM RES, V30, P1615, DOI 10.1007/s11064-005-8986-6
   Alzoubi KH, 2018, BEHAV BRAIN RES, V336, P93, DOI 10.1016/j.bbr.2017.08.047
   Askari M, 2020, INT J OBESITY, V44, P2080, DOI 10.1038/s41366-020-00650-z
   Baslow MH, 2003, NEUROCHEM RES, V28, P941, DOI 10.1023/A:1023250721185
   Boitard C, 2016, FRONT BEHAV NEUROSCI, V10, DOI 10.3389/fnbeh.2016.00225
   Bracke A, 2019, J EXP NEUROSCI, V13, DOI 10.1177/1179069519883580
   Carraro RS, 2018, MOL CELL ENDOCRINOL, V460, P238, DOI 10.1016/j.mce.2017.07.029
   Corcoba A, 2016, INT J NEUROPSYCHOPH, V19, DOI 10.1093/ijnp/pyv110
   Cudalbu C, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0069782
   de Bem AF, 2021, FRONT NEUROSCI-SWITZ, V14, DOI 10.3389/fnins.2020.604150
   De Paula GC, 2021, NUTR NEUROSCI, V24, P978, DOI 10.1080/1028415X.2019.1704472
   Dong YF, 2021, NAT NEUROSCI, V24, P489, DOI 10.1038/s41593-021-00801-z
   Duarte AI, 2018, NEUROPHARMACOLOGY, V136, P223, DOI 10.1016/j.neuropharm.2018.01.044
   Duarte JMN, 2012, HSOA J DIABETES META, V3
   Duarte JMN, 2019, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.01015
   Duarte JMN, 2014, NEUROBIOL AGING, V35, P1660, DOI 10.1016/j.neurobiolaging.2014.01.135
   Duarte JMN, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0021899
   Duarte JMN, 2012, NEUROIMAGE, V61, P342, DOI 10.1016/j.neuroimage.2011.12.038
   Duarte Joao M N, 2009, Front Neuroenergetics, V1, P6, DOI 10.3389/neuro.14.006.2009
   Duarte JMN, 2009, J NEUROCHEM, V111, P368, DOI 10.1111/j.1471-4159.2009.06349.x
   Fernández-Arjona MD, 2017, FRONT CELL NEUROSCI, V11, DOI 10.3389/fncel.2017.00235
   Frisardi V, 2010, AGEING RES REV, V9, P399, DOI 10.1016/j.arr.2010.04.007
   Gapp K, 2017, J CEREBR BLOOD F MET, V37, P2423, DOI 10.1177/0271678X16667525
   Garcia-Serrano AM, 2020, FRONT NEUROSCI-SWITZ, V14, DOI 10.3389/fnins.2020.00229
   Girault FM, 2019, NEUROTOX RES, V36, P268, DOI 10.1007/s12640-017-9821-y
   Hansen SH, 2010, J BIOMED SCI, V17, DOI 10.1186/1423-0127-17-S1-S23
   Huber G, 2021, J CEREBR BLOOD F MET, V41, P2356, DOI 10.1177/0271678X211003497
   Jujic A, 2021, HYPERTENSION, V78, P195, DOI 10.1161/HYPERTENSIONAHA.120.17379
   Kirmani BF, 2002, MOL BRAIN RES, V107, P176, DOI 10.1016/S0169-328X(02)00490-4
   Lang BT, 2009, BRAIN RES, V1258, P25, DOI 10.1016/j.brainres.2008.12.026
   Li LL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0066069
   Lindqvist A, 2006, EUR J NEUROL, V13, P1385, DOI 10.1111/j.1468-1331.2006.01500.x
   Liu ZG, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-05217-z
   Lizarbe B, 2019, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00985
   Lizarbe B, 2019, INT J OBESITY, V43, P1295, DOI 10.1038/s41366-018-0224-9
   McLean FH, 2019, NUTR METAB, V16, DOI 10.1186/s12986-019-0387-y
   Mohr AA, 2021, J CEREBR BLOOD F MET, V41, P1734, DOI 10.1177/0271678X20942397
   Popa-Wagner A, 2020, NEURAL REGEN RES, V15, P394, DOI 10.4103/1673-5374.266045
   Prut L, 2003, EUR J PHARMACOL, V463, P3, DOI 10.1016/S0014-2999(03)01272-X
   Ribeiro M, 2018, J MAGN RESON IMAGING, V48, P757, DOI 10.1002/jmri.25942
   Robison LS, 2020, ENEURO, V7, DOI 10.1523/ENEURO.0391-19.2019
   Sickmann HM, 2010, J CEREBR BLOOD F MET, V30, P1527, DOI 10.1038/jcbfm.2010.61
   Snyder JS, 2020, BEHAV BRAIN RES, V382, DOI 10.1016/j.bbr.2020.112470
   Soares AF, 2018, MAGN RESON MATER PHY, V31, P341, DOI 10.1007/s10334-017-0654-8
   Spauwen PJJ, 2013, DIABETES CARE, V36, P1554, DOI 10.2337/dc12-0746
   Thaler JP, 2012, J CLIN INVEST, V122, P153, DOI 10.1172/JCI59660
   Vagena E, 2019, TRANSL PSYCHIAT, V9, DOI 10.1038/s41398-019-0470-1
   Valdearcos M, 2017, CELL METAB, V26, P185, DOI 10.1016/j.cmet.2017.05.015
   van der Graaf M, 2004, NMR BIOMED, V17, P405, DOI 10.1002/nbm.896
   Volinsky R, 2013, FEBS J, V280, P2806, DOI 10.1111/febs.12247
   Wang WT, 2012, J NEUROCHEM, V121, P407, DOI 10.1111/j.1471-4159.2012.07698.x
   Yoon H, 2016, BBA-MOL BASIS DIS, V1862, P545, DOI 10.1016/j.bbadis.2016.01.019
   Zhao X, 2018, BIOSCIENCE REP, V38, DOI 10.1042/BSR20180660
NR 53
TC 37
Z9 38
U1 3
U2 39
PU INT SOC AGING & DISEASE
PI FORT WORTH
PA EDITORIAL OFF, 3400 CAMP BOWIE BLVD, FORT WORTH, TX 76106 USA
SN 2152-5250
J9 AGING DIS
JI Aging Dis.
PD FEB
PY 2022
VL 13
IS 1
BP 267
EP 283
DI 10.14336/AD.2021.0720
PG 17
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA ZZ4DK
UT WOS:000773221500017
PM 35111373
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Beckie, TM
AF Beckie, Theresa M.
TI A Systematic Review of Allostatic Load, Health, and Health Disparities
SO BIOLOGICAL RESEARCH FOR NURSING
LA English
DT Review
DE allostasis; health; allostatic load
ID CUMULATIVE BIOLOGICAL RISK; CHRONIC-FATIGUE-SYNDROME; SELF-RATED HEALTH;
   SOCIOECONOMIC-STATUS; PHYSIOLOGICAL DYSREGULATION; METABOLIC SYNDROME;
   CHRONIC STRESS; SOCIAL RELATIONSHIPS; NATIONAL SAMPLE; HEART-DISEASE
AB The theoretical constructs of allostasis and allostatic load (AL) have contributed to our understanding of how constantly changing social and environmental factors impact physiological functioning and shape health and aging disparities, particularly along socioeconomic, gendered, racial, and ethnic lines. AL represents the cumulative dysregulation of biological systems with prolonged or poorly regulated allostatic responses. Nearly two decades of empirical research has focused on operationalizing the AL construct for examining the antecedents and health outcomes accompanying multisystem biological dysregulation. The purpose of this systematic review is to examine the empirical literature that quantifies the AL construct; the review also evaluates the social, environmental, and genetic antecedents of AL as well as its predictive utility for a variety of health outcomes. A total of 58 articles published between 1997 and 2012 were retrieved, analyzed, and synthesized. The results revealed considerable heterogeneity in the operationalization of AL and the measurement of AL biomarkers, making interpretations and comparisons across studies challenging. There is, however, empirical substantiation for the relationships between AL and socioeconomic status, social relationships, workplace, lifestyle, race/ethnicity, gender, stress exposure, and genetic factors. The literature also demonstrated associations between AL and physical and mental health and all-cause mortality. Targeting the antecedents of AL during key developmental periods is essential for improving public health. Priorities for future research include conducting prospective longitudinal studies, examining a broad range of antecedent allostatic challenges, and collecting reliable measures of multisystem dysregulation explicitly designed to assess AL, at multiple time points, in population-representative samples.
C1 Univ S Florida, Coll Nursing, Tampa, FL 33612 USA.
C3 State University System of Florida; University of South Florida
RP Beckie, TM (corresponding author), Univ S Florida, Coll Nursing, 12901 Bruce B Downs Blvd,MDC22, Tampa, FL 33612 USA.
EM tbeckie@health.usf.edu
RI Beckie, Theresa/R-4212-2019
CR [Anonymous], 2012, Healthy People 2020
   Baez-Camargo C., 2011, Accountability for better healthcare provision: A framework and guidelines to define understand and assess accountability in health systems, DOI DOI 10.17226/13145
   Beckstead JW, 2011, MED DECIS MAKING, V31, P79, DOI 10.1177/0272989X10373401
   Bellingrath S, 2009, STRESS, V12, P37, DOI 10.1080/10253890802042041
   Bird CE, 2010, J EPIDEMIOL COMMUN H, V64, P860, DOI 10.1136/jech.2008.084814
   Borrell LN, 2010, PUBLIC HEALTH REP, V125, P810, DOI 10.1177/003335491012500608
   Carlson ED, 2005, RES NURS HEALTH, V28, P306, DOI 10.1002/nur.20084
   Carlsson AC, 2011, DIABETES METAB, V37, P446, DOI 10.1016/j.diabet.2011.03.005
   Chyu L, 2011, J WOMENS HEALTH, V20, P575, DOI 10.1089/jwh.2010.2170
   Clark Michael S, 2007, Psychol Health Med, V12, P18, DOI 10.1080/13548500500429338
   Cohen S, 2007, JAMA-J AM MED ASSOC, V298, P1685, DOI 10.1001/jama.298.14.1685
   Crews DE, 2007, AM J PHYS ANTHROPOL, V133, P1028, DOI 10.1002/ajpa.20612
   Crimmins EM, 2007, AM J PUBLIC HEALTH, V97, P1305, DOI 10.2105/AJPH.2006.091892
   Crimmins EM, 2009, J GERONTOL A-BIOL, V64, P286, DOI 10.1093/gerona/gln010
   Crimmins EM, 2003, EXP GERONTOL, V38, P731, DOI 10.1016/S0531-5565(03)00099-8
   Danese A, 2012, PHYSIOL BEHAV, V106, P29, DOI 10.1016/j.physbeh.2011.08.019
   de Castro AB, 2010, AAOHN J, V58, P185, DOI 10.3928/08910162-20100428-01
   Dowd JB, 2006, J EPIDEMIOL COMMUN H, V60, P633, DOI 10.1136/jech.2005.040816
   Dowd JB, 2009, INT J EPIDEMIOL, V38, P1297, DOI 10.1093/ije/dyp277
   Gallo LC, 2011, ANN BEHAV MED, V41, P21, DOI 10.1007/s12160-010-9233-1
   Ganzel BL, 2010, PSYCHOL REV, V117, P134, DOI 10.1037/a0017773
   Geronimus AT, 2006, AM J PUBLIC HEALTH, V96, P826, DOI 10.2105/AJPH.2004.060749
   Glei DA, 2007, PSYCHOSOM MED, V69, P769, DOI 10.1097/PSY.0b013e318157cba6
   Glover DA, 2006, ANN NY ACAD SCI, V1071, P442, DOI 10.1196/annals.1364.039
   Goertzel BN, 2006, PHARMACOGENOMICS, V7, P485, DOI 10.2217/14622416.7.3.485
   Goldman N, 2006, J GERONTOL A-BIOL, V61, P1070, DOI 10.1093/gerona/61.10.1070
   Goldman N, 2006, EXP GERONTOL, V41, P862, DOI 10.1016/j.exger.2006.06.050
   Groer M., 2010, The psychoneuroimmunology of chronic disease: Exploring the links between inflammation, stress, and illness, P183
   Gruenewald TL, 2006, P NATL ACAD SCI USA, V103, P14158, DOI 10.1073/pnas.0606215103
   Gruenewald TL, 2009, J AM GERIATR SOC, V57, P1525, DOI 10.1111/j.1532-5415.2009.02389.x
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Gustafsson PE, 2012, ANN BEHAV MED, V43, P117, DOI 10.1007/s12160-011-9309-6
   Gustafsson PE, 2011, J EPIDEMIOL COMMUN H, V65, P986, DOI 10.1136/jech.2010.108332
   Hampson SE, 2009, J HEALTH PSYCHOL, V14, P232, DOI 10.1177/1359105308100207
   Hasson D, 2009, J HEALTH PSYCHOL, V14, P568, DOI 10.1177/1359105309103576
   Hawkley LC, 2011, PSYCHOPHYSIOLOGY, V48, P1134, DOI 10.1111/j.1469-8986.2011.01185.x
   Hu PF, 2007, J BIOSOC SCI, V39, P545, DOI 10.1017/S0021932006001556
   Juster R.P., 2011, PHYSIOL BEHAV, V104, P360
   Juster RP, 2011, DEV PSYCHOPATHOL, V23, P725, DOI 10.1017/S0954579411000289
   Juster RP, 2011, PSYCHONEUROENDOCRINO, V36, P797, DOI 10.1016/j.psyneuen.2010.11.001
   Juster RP, 2010, NEUROSCI BIOBEHAV R, V35, P2, DOI 10.1016/j.neubiorev.2009.10.002
   Kaestner R, 2009, SOC SCI QUART, V90, P1089, DOI 10.1111/j.1540-6237.2009.00648.x
   Karatsoreos IN, 2011, TRENDS COGN SCI, V15, P576, DOI 10.1016/j.tics.2011.10.005
   Karlamangla AS, 2002, J CLIN EPIDEMIOL, V55, P696, DOI 10.1016/S0895-4356(02)00399-2
   Kubzansky LD, 1999, ANN BEHAV MED, V21, P330, DOI 10.1007/BF02895966
   Langelaan S, 2007, INT J BEHAV MED, V14, P213, DOI 10.1007/BF03002995
   Li W, 2007, STRESS HEALTH, V23, P257, DOI 10.1002/smi.1145
   Mair CA, 2011, HEALTH PLACE, V17, P978, DOI 10.1016/j.healthplace.2011.03.009
   Maloney EM, 2009, PSYCHOSOM MED, V71, P549, DOI 10.1097/PSY.0b013e3181a4fea8
   Maloney EM, 2006, PHARMACOGENOMICS, V7, P467, DOI 10.2217/14622416.7.3.467
   Mattei J., 2011, NUTR METAB CARDIOVAS, V21, P862
   Mattei J, 2010, SOC SCI MED, V70, P1988, DOI 10.1016/j.socscimed.2010.02.024
   Matthews KA, 2010, ANN NY ACAD SCI, V1186, P146, DOI 10.1111/j.1749-6632.2009.05332.x
   McEwen Bruce S, 2006, Dialogues Clin Neurosci, V8, P367
   McEwen BS, 2006, METABOLISM, V55, pS20, DOI 10.1016/j.metabol.2006.07.008
   McEwen BS, 2011, AM J PUBLIC HEALTH, V101, pS131, DOI 10.2105/AJPH.2011.300270
   McEwen BS, 2012, NEUROPHARMACOLOGY, V62, P3, DOI 10.1016/j.neuropharm.2011.07.014
   McEwen BS, 2011, ANNU REV MED, V62, P431, DOI 10.1146/annurev-med-052209-100430
   McEwen BS, 2010, ANN NY ACAD SCI, V1186, P190, DOI 10.1111/j.1749-6632.2009.05331.x
   McEwen BS, 2010, HORM BEHAV, V57, P105, DOI 10.1016/j.yhbeh.2009.09.011
   McEwen BS, 1999, ANN NY ACAD SCI, V896, P30, DOI 10.1111/j.1749-6632.1999.tb08103.x
   McEwen BS, 2004, ANN NY ACAD SCI, V1032, P1, DOI 10.1196/annals.1314.001
   McEwen BS, 2003, HORM BEHAV, V43, P2, DOI 10.1016/S0018-506X(02)00024-7
   McEwen BS, 1998, ANN NY ACAD SCI, V840, P33, DOI 10.1111/j.1749-6632.1998.tb09546.x
   McEwen BS, 2003, METABOLISM, V52, P10, DOI 10.1053/S0026-0495(03)00295-6
   MCEWEN BS, 1993, ARCH INTERN MED, V153, P2093, DOI 10.1001/archinte.153.18.2093
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   Merkin SS, 2009, ANN EPIDEMIOL, V19, P194, DOI 10.1016/j.annepidem.2008.12.006
   Nelson KM, 2007, ETHNIC DIS, V17, P669
   Peek MK, 2010, AM J PUBLIC HEALTH, V100, P940, DOI 10.2105/AJPH.2007.129312
   Rigney T, 2010, NURS RES, V59, P322, DOI 10.1097/NNR.0b013e3181ec156b
   Roepke SK, 2011, J HEALTH PSYCHOL, V16, P58, DOI 10.1177/1359105310369188
   Roger VL, 2012, CIRCULATION, V125, pE2, DOI [10.1161/CIR.0b013e31823ac046, 10.1161/CIR.0b013e3182456d46]
   Satcher D, 2010, PUBLIC HEALTH REP, V125, P6, DOI 10.1177/00333549101250S402
   Schnorpfeil P, 2003, SOC SCI MED, V57, P647, DOI 10.1016/S0277-9536(02)00407-0
   Seeman T, 2004, SOC SCI MED, V59, P2245, DOI 10.1016/j.socscimed.2004.03.027
   Seeman TE, 1997, ARCH INTERN MED, V157, P2259
   Seeman TE, 2004, SOC SCI MED, V58, P1985, DOI 10.1016/S0277-9536(03)00402-7
   Seeman TE, 2002, PSYCHOSOM MED, V64, P395, DOI 10.1097/00006842-200205000-00004
   Seeman TE, 2001, P NATL ACAD SCI USA, V98, P4770, DOI 10.1073/pnas.081072698
   Seeman T, 2008, SOC SCI MED, V66, P72, DOI 10.1016/j.socscimed.2007.08.027
   Seeman T, 2010, AM J HUM BIOL, V22, P463, DOI 10.1002/ajhb.21018
   Seeman T, 2010, ANN NY ACAD SCI, V1186, P223, DOI 10.1111/j.1749-6632.2009.05341.x
   Seplaki CL, 2006, DEMOGRAPHY, V43, P165, DOI 10.1353/dem.2006.0009
   Seplaki CL, 2005, EXP GERONTOL, V40, P438, DOI 10.1016/j.exger.2005.03.002
   Seplaki CL, 2004, J GERONTOL A-BIOL, V59, P201
   Singer B, 1999, ANN NY ACAD SCI, V896, P96, DOI 10.1111/j.1749-6632.1999.tb08108.x
   Smith AK, 2009, PSYCHONEUROENDOCRINO, V34, P597, DOI 10.1016/j.psyneuen.2008.10.022
   Sterling P., 1988, Handbook of life stress, cognition, and health, P629
   Sun J, 2007, WORK STRESS, V21, P333, DOI 10.1080/02678370701742748
   Szanton SL, 2009, BIOL RES NURS, V10, P248, DOI 10.1177/1099800408323452
   Szanton SL, 2005, BIOL RES NURS, V7, P7, DOI 10.1177/1099800405278216
   Taylor SE, 2000, PSYCHOL REV, V107, P411, DOI 10.1037/0033-295X.107.3.411
   Taylor SE, 2011, SOC COGN AFFECT NEUR, V6, P244, DOI 10.1093/scan/nsq037
   von Thiele U, 2006, J PSYCHOSOM RES, V61, P237, DOI 10.1016/j.jpsychores.2006.01.015
   Weinstein M, 2003, J BIOSOC SCI, V35, P433, DOI 10.1017/S0021932003004334
   Wilson PWF, 1998, CIRCULATION, V97, P1837, DOI 10.1161/01.CIR.97.18.1837
   Yang Y, 2011, J GERONTOL A-BIOL, V66, P493, DOI 10.1093/gerona/glr003
NR 98
TC 376
Z9 461
U1 3
U2 127
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1099-8004
EI 1552-4175
J9 BIOL RES NURS
JI Biol. Res. Nurs.
PD OCT
PY 2012
VL 14
IS 4
SI SI
BP 311
EP 346
DI 10.1177/1099800412455688
PG 36
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 010XD
UT WOS:000309126900002
PM 23007870
DA 2025-06-11
ER

PT J
AU Kim, GM
   Woo, JM
   Jung, SY
   Shin, S
   Song, HJ
   Park, J
   Ahn, J
AF Kim, Gyung-Mee
   Woo, Jong-Min
   Jung, Sun-Young
   Shin, Sangjin
   Song, Hyun Jin
   Park, Jooyeon
   Ahn, Jeonghoon
TI Positive association between serious psychiatric outcomes and
   complications of diabetes mellitus in patients with depressive disorders
SO INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE
LA English
DT Article
DE Depression; diabetes; comorbidity; serious outcomes
ID COMORBID DEPRESSION; RISK-FACTORS; METABOLIC SYNDROME; GLYCEMIC CONTROL;
   TYPE-2; HEALTH; ADULTS; OLDER; INDIVIDUALS; PREVALENCE
AB Objectives Depression and diabetes are closely biologically and behaviorally intertwined. We examined the impact of comorbid diabetes mellitus on the incidence of serious psychiatric outcomes among patients with depression.
   Methods We used claims data from the Korean Health Insurance Review & Assessment Service database of patients who were diagnosed with depression within one year of an index prescription for antidepressants between January 2007 and June 2008. We investigated the association between the comorbidity of diabetes mellitus and serious psychiatric outcomes of depression, such as psychiatric hospitalization, psychiatric emergency room visits, and suicide attempts.
   Results Among 200,936 patients with depression, 74,160 (36.9%) had diabetes mellitus, including 57,418 (28.6%) with complications. The incidence of serious psychiatric outcomes was 3.3% in patients with depression without diabetes and 6.7% in patients with depression and diabetes mellitus. Patients with depression and diabetes mellitus complications showed higher rates of serious outcomes than that did those without diabetes mellitus complications (odds ratio, 1.19; 95% confidence interval, 1.11-1.13). Similarly, depressed patients with micro and macrovascular diabetic complications were more likely to experience serious outcomes than those without diabetes mellitus complications (odds ratio, 2.2; 95% confidence interval, 2.07-2.34).
   Conclusions Our results showed that comorbid diabetes mellitus can increase the risk of serious outcomes of depression, such as suicide and hospitalization, and thus may alter the antidepressants prescription patterns and healthcare service use among patients with depressive disorders.
C1 [Kim, Gyung-Mee; Woo, Jong-Min; Jung, Sun-Young; Shin, Sangjin; Song, Hyun Jin; Park, Jooyeon; Ahn, Jeonghoon] Natl Evidence Based Healthcare Collaborating Agcy, Seoul, South Korea.
   [Kim, Gyung-Mee] Inje Univ, Sch Med, Haeundae Paik Hosp, Dept Psychiat, Busan, South Korea.
   [Woo, Jong-Min] Inje Univ, Seoul Paik Hosp, Dept Psychiat, Sch Med, Seoul 100032, South Korea.
   [Woo, Jong-Min] Inje Univ, Stress Res Inst, Seoul 100032, South Korea.
   [Jung, Sun-Young] Korea Inst Drug Safety & Risk Management KIDS, Seoul, South Korea.
   [Song, Hyun Jin] Sungkyunkwan Univ, Sch Pharm, Suwon, South Korea.
C3 National Evidence-based Healthcare Collaborating Agency (NECA); Inje
   University; Inje University; Inje University; Sungkyunkwan University
   (SKKU)
RP Woo, JM (corresponding author), Inje Univ, Seoul Paik Hosp, Dept Psychiat, 9 Mareunnae Ro, Seoul 100032, South Korea.
EM jongmin.woo@gmail.com
RI Woo, Jong/D-2353-2014; Ahn, Jeonghoon/CAA-1956-2022
OI Woo, Jongmin/0000-0003-1314-126X; Ahn, Jeonghoon/0000-0002-0177-0192
FU National Evidence-based Healthcare Collaborating Agency in Korea
   [NA09-008, NA10-003]
FX This study was fully funded by the National Evidence-based Healthcare
   Collaborating Agency in Korea (NA09-008, NA10-003). This study was not
   funded by any pharmaceutical company.
CR Almeida OP, 2008, ARCH GEN PSYCHIAT, V65, P1286, DOI 10.1001/archpsyc.65.11.1286
   Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   Baldwin RC, 2010, INT PSYCHOGERIATR, V22, P1216, DOI 10.1017/S1041610210000864
   Black SA, 2003, DIABETES CARE, V26, P2822, DOI 10.2337/diacare.26.10.2822
   Blay SL, 2011, J AFFECT DISORDERS, V134, P77, DOI 10.1016/j.jad.2011.05.012
   Ciechanowski PS, 2000, ARCH INTERN MED, V160, P3278, DOI 10.1001/archinte.160.21.3278
   Ciechanowski PS, 2003, GEN HOSP PSYCHIAT, V25, P246, DOI 10.1016/S0163-8343(03)00055-0
   d'Audiffret AC, 2010, J APPL PHYSIOL, V108, P1041, DOI 10.1152/japplphysiol.01440.2009
   de Groot M, 2001, PSYCHOSOM MED, V63, P619, DOI 10.1097/00006842-200107000-00015
   Deckers K, 2015, INT J GERIATR PSYCH, V30, P234, DOI 10.1002/gps.4245
   Due-Christensen M, 2012, DIABETIC MED, V29, P251, DOI 10.1111/j.1464-5491.2011.03521.x
   Eaton WW, 1996, DIABETES CARE, V19, P1097, DOI 10.2337/diacare.19.10.1097
   Egede LE, 2002, DIABETES CARE, V25, P464, DOI 10.2337/diacare.25.3.464
   Engum A, 2007, J PSYCHOSOM RES, V62, P31, DOI 10.1016/j.jpsychores.2006.07.009
   Gendelman N, 2009, DIABETES CARE, V32, P575, DOI 10.2337/dc08-1835
   Hänninen JA, 1999, DIABETES CARE, V22, P997, DOI 10.2337/diacare.22.6.997
   Hawton K, 2005, J CLIN PSYCHIAT, V66, P693, DOI 10.4088/JCP.v66n0604
   HERBERT TB, 1993, PSYCHOL BULL, V113, P472, DOI 10.1037/0033-2909.113.3.472
   Kalsekar ID, 2006, ANN PHARMACOTHER, V40, P605, DOI 10.1345/aph.1G606
   Katon W, 2004, DIABETES CARE, V27, P914, DOI 10.2337/diacare.27.4.914
   Katon WJ, 2004, J GEN INTERN MED, V19, P1192, DOI 10.1111/j.1525-1497.2004.30405.x
   Knol MJ, 2006, DIABETOLOGIA, V49, P837, DOI 10.1007/s00125-006-0159-x
   Ludman EJ, 2004, GEN HOSP PSYCHIAT, V26, P430, DOI 10.1016/j.genhosppsych.2004.08.010
   Lustman PJ, 2007, DIABETES CARE, V30, P459, DOI 10.2337/dc06-1769
   Lustman PJ, 1997, PSYCHOSOM MED, V59, P241, DOI 10.1097/00006842-199705000-00007
   Moulton CD, 2015, BRAIN IMAGING BEHAV, V9, P651, DOI 10.1007/s11682-014-9348-2
   Musselman DL, 2003, BIOL PSYCHIAT, V54, P317, DOI 10.1016/S0006-3223(03)00569-9
   O'Brien SM, 2007, J PSYCHIAT RES, V41, P326, DOI 10.1016/j.jpsychires.2006.05.013
   O'Brien SM, 2006, BRIT J PSYCHIAT, V188, P449, DOI 10.1192/bjp.bp.105.011015
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pan A, 2011, ARCH GEN PSYCHIAT, V68, P42, DOI 10.1001/archgenpsychiatry.2010.176
   Penninx BWJH, 2003, BIOL PSYCHIAT, V54, P566, DOI 10.1016/S0006-3223(02)01811-5
   Piette JD, 2004, AM J MANAG CARE, V10, P152
   Poncelet AN, 2003, GERIATRICS-US, V58, P16
   Pouwer F, 2010, DIABETIC MED, V27, P217, DOI 10.1111/j.1464-5491.2009.02903.x
   Roy T, 2012, J AFFECT DISORDERS, V142, pS8, DOI 10.1016/S0165-0327(12)70004-6
   Sacco WP, 2005, HEALTH PSYCHOL, V24, P630, DOI 10.1037/0278-6133.24.6.630
   Sharif Farkhondeh, 2014, Iran J Nurs Midwifery Res, V19, P529
   Sindrup SH, 2000, NEUROLOGY, V55, P915, DOI 10.1212/WNL.55.7.915
   Surwit RS, 2005, DIABETES RES CLIN PR, V69, P78, DOI 10.1016/j.diabres.2004.11.002
   Talbot F, 2000, DIABETES CARE, V23, P1556, DOI 10.2337/diacare.23.10.1556
   Thomas AJ, 2005, AM J PSYCHIAT, V162, P175, DOI 10.1176/appi.ajp.162.1.175
   van Dooren FEP, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057058
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vickers KS, 2006, AM J HEALTH BEHAV, V30, P353, DOI 10.5993/AJHB.30.4.2
   Welch GN, 1998, NEW ENGL J MED, V338, P1042, DOI 10.1056/NEJM199804093381507
   Williams MM, 2007, DIABETES CARE, V30, P801, DOI 10.2337/dc06-1825
   Zhang P, 2012, DIABETES CARE, V35, P2250, DOI 10.2337/dc11-2478
NR 48
TC 10
Z9 13
U1 0
U2 12
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0091-2174
EI 1541-3527
J9 INT J PSYCHIAT MED
JI Int. J. Psychiatr. Med.
PD AUG
PY 2015
VL 50
IS 2
BP 131
EP 146
DI 10.1177/0091217415605024
PG 16
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CU1VE
UT WOS:000363309000001
PM 26353830
DA 2025-06-11
ER

PT J
AU Vijayan, VK
AF Vijayan, Vannan Kandi
TI Morbidities associated with obstructive sleep apnea
SO EXPERT REVIEW OF RESPIRATORY MEDICINE
LA English
DT Review
DE cardiac arrhythmias; continuous positive airway pressure; endothelial
   dysfunction; hypertension; intermittent hypoxia; metabolic syndrome;
   obstructive sleep apnea; oxidative stress
ID POSITIVE AIRWAY PRESSURE; C-REACTIVE PROTEIN; SYMPATHETIC-NERVE
   ACTIVITY; IMPROVES ENDOTHELIAL FUNCTION; OXIDATIVE STRESS;
   PULMONARY-HYPERTENSION; LIPID-PEROXIDATION; BLOOD-PRESSURE;
   HEART-FAILURE; CARDIOVASCULAR-DISEASE
AB Obstructive sleep apnea (OSA)-induced biological changes include intermittent hypoxia, intermittent hypercapnia, intrathoracic pressure changes, sympathetic activation and sleep fragmentation. OSA can cause metabolic dysregulation, endothelial dysfunction, systemic inflammation, oxidative stress and hypercoagulation, and neurohumoral changes. There is evidence suggesting that OSA is independently associated with metabolic syndrome. OSA has been shown to increase the risk for systemic hypertension, pulmonary vascular disease, ischemic heart disease, cerebral vascular disease, congestive heart failure and arrhythmias. Although there are evidences accumulating that there may be a causal relationship between OSA and cardiovascular disorders, there is a need for more data from randomized controlled intervention trials to confirm this relationship. Many risk factors of OSA (age, male gender and obesity) are also known risk factors for cardiovascular disease. Severe OSA-hypopnea significantly increases the risk of fatal and nonfatal cardiovascular events in both men and women, and continuous positive airway pressure treatment reduces this risk in both. Neurocognitive consequences of OSA include daytime sleepiness, loss of alertness, memory deficit, reduced vigilance, impaired executive function, increased risk for automobile and occupational accidents, and decreased quality of life.
C1 [Vijayan, Vannan Kandi] Bhopal Mem Hosp & Res Ctr, Indian Council Med Res, Bhopal 462036, India.
   [Vijayan, Vannan Kandi] Univ Delhi, Vallabhbhai Patel Chest Inst, Delhi 110007, India.
C3 Indian Council of Medical Research (ICMR); ICMR - Bhopal Memorial
   Hospital & Research Center (BMHRC); University of Delhi
RP Vijayan, VK (corresponding author), Bhopal Mem Hosp & Res Ctr, Indian Council Med Res, Bhopal 462036, India.
EM vijayanvk@hotmail.com
CR Aloia MS, 2004, J INT NEUROPSYCH SOC, V10, P772, DOI 10.1017/S1355617704105134
   Andreou G, 2007, ARCH CLIN NEUROPSYCH, V22, P225, DOI 10.1016/j.acn.2006.12.008
   Martínez-García MA, 2009, AM J RESP CRIT CARE, V180, P36, DOI 10.1164/rccm.200808-1341OC
   [Anonymous], 2011, Adv Cardiol, V46, P139, DOI 10.1159/000325108
   Arias MA, 2006, EUR HEART J, V27, P1106, DOI 10.1093/eurheartj/ehi807
   Arzt M, 2005, AM J RESP CRIT CARE, V172, P1447, DOI 10.1164/rccm.200505-702OC
   Arzt M, 2012, EUR RESPIR J, V40, P919, DOI 10.1183/09031936.00176711
   Atkeson A, 2008, VASC HEALTH RISK MAN, V4, P1327, DOI 10.2147/VHRM.S4078
   Barceló A, 2006, EUR RESPIR J, V27, P756, DOI 10.1183/09031936.06.00067605
   Barceló A, 2000, EUR RESPIR J, V16, P644, DOI 10.1034/j.1399-3003.2000.16d13.x
   Beebe DW, 2003, SLEEP, V26, P298, DOI 10.1093/sleep/26.3.298
   Bradley TD, 2001, CHEST, V119, P1827, DOI 10.1378/chest.119.6.1827
   Bravata DM, 2011, SLEEP, V34, P1271, DOI 10.5665/SLEEP.1254
   Budweiser S, 2009, J SEX MED, V6, P3147, DOI 10.1111/j.1743-6109.2009.01372.x
   Campos-Rodriguez F, 2012, ANN INTERN MED, V156, P115, DOI 10.7326/0003-4819-156-2-201201170-00006
   Canessa N, 2011, AM J RESP CRIT CARE, V183, P1419, DOI 10.1164/rccm.201005-0693OC
   Cano-Pumarega I, 2011, AM J RESP CRIT CARE, V184, P1299, DOI 10.1164/rccm.201101-0130OC
   Caples SM, 2005, ANN INTERN MED, V142, P187, DOI 10.7326/0003-4819-142-3-200502010-00010
   CARLSON JT, 1993, CHEST, V103, P1763, DOI 10.1378/chest.103.6.1763
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   Christou K, 2003, SLEEP MED, V4, P225, DOI 10.1016/S1389-9457(02)00253-8
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Coughlin SR, 2004, EUR HEART J, V25, P735, DOI 10.1016/j.ehj.2004.02.021
   Décary A, 2000, SLEEP, V23, P369
   DEEGAN PC, 1995, EUR RESPIR J, V8, P1161, DOI 10.1183/09031936.95.08071161
   Dimsdale JE, 2000, HYPERTENSION, V35, P144, DOI 10.1161/01.HYP.35.1.144
   Dyugovskaya L, 2003, AM J RESP CRIT CARE, V168, P242, DOI 10.1164/rccm.200210-1226OC
   Dyugovskaya L, 2002, AM J RESP CRIT CARE, V165, P934, DOI 10.1164/ajrccm.165.7.2104126
   EISENBERG E, 1990, NEW ENGL J MED, V322, P932
   El Solh AA, 2006, EUR RESPIR J, V27, P997, DOI 10.1183/09031936.06.00101005
   Felver-Gant JC, 2007, J CLIN SLEEP MED, V3, P589
   Ferini-Strambi L, 2003, BRAIN RES BULL, V61, P87, DOI 10.1016/S0361-9230(03)00068-6
   Flaherty Kevin R, 2011, Proc Am Thorac Soc, V8, P398, DOI 10.1513/pats.201108-044TT
   FLETCHER EC, 1987, SLEEP, V10, P35, DOI 10.1093/sleep/10.1.35
   Gami AS, 2007, J AM COLL CARDIOL, V49, P565, DOI 10.1016/j.jacc.2006.08.060
   Gami AS, 2005, NEW ENGL J MED, V352, P1206, DOI 10.1056/NEJMoa041832
   Golbin Jason M, 2008, Proc Am Thorac Soc, V5, P200, DOI 10.1513/pats.200708-143MG
   Gonçalves MA, 2005, SLEEP MED, V6, P333, DOI 10.1016/j.sleep.2005.03.001
   Gottlieb DJ, 2010, CIRCULATION, V122, P352, DOI 10.1161/CIRCULATIONAHA.109.901801
   Gozal D, 2008, AM J RESP CRIT CARE, V177, P369, DOI 10.1164/rccm.200608-1190PP
   Grebe M, 2006, AM J RESP CRIT CARE, V173, P897, DOI 10.1164/rccm.200508-1223OC
   Grimm W, 2000, AM J CARDIOL, V86, P688, DOI 10.1016/S0002-9149(00)01055-9
   GUILLEMINAULT C, 1983, AM J CARDIOL, V52, P490, DOI 10.1016/0002-9149(83)90013-9
   Gurubhagavatula I, 2010, INDIAN J MED RES, V131, P188
   Haentjens P, 2007, ARCH INTERN MED, V167, P757, DOI 10.1001/archinte.167.8.757
   Htoo AK, 2006, SLEEP BREATH, V10, P43, DOI 10.1007/s11325-005-0046-6
   Hu FB, 2000, J AM COLL CARDIOL, V35, P308, DOI 10.1016/S0735-1097(99)00540-9
   Hui DS, 2004, CHEST, V125, P1768, DOI 10.1378/chest.125.5.1768
   Iber C., 2007, AASM MANUAL SCORING, V1
   Ip MSM, 2000, AM J RESP CRIT CARE, V162, P2166, DOI 10.1164/ajrccm.162.6.2002126
   Sánchez AI, 2009, SLEEP MED REV, V13, P223, DOI 10.1016/j.smrv.2008.07.002
   Kaneko Y, 2003, NEW ENGL J MED, V348, P1233, DOI 10.1056/NEJMoa022479
   Kenchaiah S, 2002, NEW ENGL J MED, V347, P305, DOI 10.1056/NEJMoa020245
   Kheirandish-Gozal L, 2006, J CLIN SLEEP MED, V2, P301
   Kohler M, 2009, THORAX, V64, P67, DOI 10.1136/thx.2008.097931
   Kuniyoshi FHS, 2010, INDIAN J MED RES, V131, P196
   Lam JCM, 2007, CURR OPIN PULM MED, V13, P484, DOI 10.1097/MCP.0b013e3282efae9c
   Lam JCM, 2012, RESPIROLOGY, V17, P223, DOI 10.1111/j.1440-1843.2011.02081.x
   Lau EYY, 2010, J INT NEUROPSYCH SOC, V16, P1077, DOI 10.1017/S1355617710000901
   Lavie L, 2005, ATHEROSCLEROSIS, V183, P183, DOI 10.1016/j.atherosclerosis.2005.06.024
   Lavie L, 2004, SLEEP, V27, P123
   Lavie P, 2000, BRIT MED J, V320, P479, DOI 10.1136/bmj.320.7233.479
   LEUENBERGER U, 1995, J APPL PHYSIOL, V79, P581, DOI 10.1152/jappl.1995.79.2.581
   Lim W, 2007, J CLIN SLEEP MED, V3, P380
   Lui MMS, 2009, CHEST, V135, P950, DOI 10.1378/chest.08-1798
   Mansfield DR, 2004, AM J RESP CRIT CARE, V169, P361, DOI 10.1164/rccm.200306-752OC
   Marcus CL, 2012, AM J RESP CRIT CARE, V185, P998, DOI 10.1164/rccm.201112-2167OC
   Marin JM, 2005, LANCET, V365, P1046, DOI 10.1016/S0140-6736(05)71141-7
   Martínez-García MA, 2012, EUR RESPIR J, V39, P906, DOI 10.1183/09031936.00011311
   Mason RH, 2011, AM J RESP CRIT CARE, V183, P668, DOI 10.1164/rccm.201001-0051OC
   MCCORD JM, 1985, NEW ENGL J MED, V312, P159
   Mehra R, 2006, AM J RESP CRIT CARE, V173, P910, DOI 10.1164/rccm.200509-1442OC
   Minnerup J, 2012, STROKE, V43, P1137, DOI 10.1161/STROKEAHA.111.637611
   Narkiewicz K, 1998, CIRCULATION, V98, P1071, DOI 10.1161/01.CIR.98.11.1071
   Narkiewicz K, 2003, ACTA PHYSIOL SCAND, V177, P385, DOI 10.1046/j.1365-201X.2003.01091.x
   Netzer N, 1998, STROKE, V29, P87, DOI 10.1161/01.STR.29.1.87
   Nieto FJ, 2000, JAMA-J AM MED ASSOC, V283, P1829, DOI 10.1001/jama.283.14.1829
   O'Connor GT, 2009, AM J RESP CRIT CARE, V179, P1159, DOI 10.1164/rccm.200712-1809OC
   Öztürk L, 2003, CLIN CHIM ACTA, V332, P83, DOI 10.1016/S0009-8981(03)00126-8
   Peppard PE, 2000, NEW ENGL J MED, V342, P1378, DOI 10.1056/NEJM200005113421901
   Pepperell JCT, 2002, LANCET, V359, P204, DOI 10.1016/S0140-6736(02)07445-7
   Phillips BG, 1999, J HYPERTENS, V17, P61, DOI 10.1097/00004872-199917010-00010
   Phillips BG, 2000, AM J PHYSIOL-HEART C, V279, pH234, DOI 10.1152/ajpheart.2000.279.1.H234
   Pialoux V, 2009, AM J RESP CRIT CARE, V180, P1002, DOI 10.1164/rccm.200905-0671OC
   Prabhakar NR, 2002, AM J RESP CRIT CARE, V165, P859, DOI 10.1164/ajrccm.165.7.2202030c
   Presberg KW, 2003, CURR OPIN PULM MED, V9, P131, DOI 10.1097/00063198-200303000-00007
   Punjabi Naresh M, 2008, Proc Am Thorac Soc, V5, P136, DOI 10.1513/pats.200709-155MG
   Punjabi NM, 2007, SLEEP, V30, P29, DOI 10.1093/sleep/30.1.29
   Redline S, 2010, AM J RESP CRIT CARE, V182, P269, DOI 10.1164/rccm.200911-1746OC
   Sadasivam K, 2011, Indian J Chest Dis Allied Sci, V53, P153
   SAJKOV D, 1994, AM J RESP CRIT CARE, V149, P416, DOI 10.1164/ajrccm.149.2.8306039
   Saunamäki T, 2009, CLIN EEG NEUROSCI, V40, P162, DOI 10.1177/155005940904000308
   Schulz R, 2000, THORAX, V55, P1046, DOI 10.1136/thorax.55.12.1046
   Shamsuzzaman ASM, 2002, CIRCULATION, V105, P2462, DOI 10.1161/01.CIR.0000018948.95175.03
   Sharma SK, 2011, NEW ENGL J MED, V365, P2277, DOI 10.1056/NEJMoa1103944
   Simonneau G, 2004, J AM COLL CARDIOL, V43, p5S, DOI 10.1016/j.jacc.2004.02.037
   Sin DD, 1999, AM J RESP CRIT CARE, V160, P1101, DOI 10.1164/ajrccm.160.4.9903020
   Singh T D, 2009, Indian J Chest Dis Allied Sci, V51, P217
   Smith LA, 2007, EUR HEART J, V28, P1221, DOI 10.1093/eurheartj/ehm131
   SOMERS VK, 1993, J AUTONOM NERV SYST, V44, P253, DOI 10.1016/0165-1838(93)90038-V
   Suzuki YJ, 2006, FREE RADICAL BIO MED, V40, P1683, DOI 10.1016/j.freeradbiomed.2006.01.008
   Svatikova A, 2005, EUR HEART J, V26, P2435, DOI 10.1093/eurheartj/ehi440
   Tan KCB, 2006, SLEEP, V29, P329, DOI 10.1093/sleep/29.3.329
   Tan KCB, 2006, ATHEROSCLEROSIS, V184, P377, DOI 10.1016/j.atherosclerosis.2005.04.024
   Tasali Esra, 2008, Proc Am Thorac Soc, V5, P207, DOI 10.1513/pats.200708-139MG
   Tauman R, 2004, PEDIATRICS, V113, pE564, DOI 10.1542/peds.113.6.e564
   Thomas B., 2012, Am J Respir Crit Care Med, V18, P1271
   Varol E, 2011, PLATELETS, V22, P552, DOI 10.3109/09537104.2011.578182
   von Känel R, 2003, CHEST, V124, P1956, DOI 10.1378/chest.124.5.1956
   Waravdekar NV, 1996, AM J RESP CRIT CARE, V153, P1333, DOI 10.1164/ajrccm.153.4.8616563
   Wolf J, 2007, NUTR METAB CARDIOVAS, V17, P233, DOI 10.1016/j.numecd.2006.12.005
   Yaggi HK, 2005, NEW ENGL J MED, V353, P2034, DOI 10.1056/NEJMoa043104
   Yamauchi M, 2005, CHEST, V127, P1674, DOI 10.1378/chest.127.5.1674
   Young T, 2002, AM J RESP CRIT CARE, V165, P1217, DOI 10.1164/rccm.2109080
NR 114
TC 72
Z9 83
U1 0
U2 16
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1747-6348
EI 1747-6356
J9 EXPERT REV RESP MED
JI Expert Rev. Respir. Med.
PD OCT
PY 2012
VL 6
IS 5
BP 557
EP 566
DI 10.1586/ERS.12.44
PG 10
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA V32NR
UT WOS:000208958400017
PM 23134249
DA 2025-06-11
ER

PT J
AU Sheikh, MY
   Choi, J
   Qadri, I
   Friedman, JE
   Sanyal, AJ
AF Sheikh, Muhammad Y.
   Choi, Jinah
   Qadri, Ishtiaq
   Friedman, Jacob E.
   Sanyal, Arun J.
TI Hepatitis C virus infection: Molecular pathways to metabolic syndrome
SO HEPATOLOGY
LA English
DT Review
ID ENDOPLASMIC-RETICULUM-STRESS; NECROSIS-FACTOR-ALPHA; MITOCHONDRIAL
   PERMEABILITY TRANSITION; ACTIVATED RECEPTOR-ALPHA; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; STELLATE CELLS; LIPOPROTEIN-LIPASE; GENE-EXPRESSION;
   NADPH OXIDASE
AB Chronic infection with hepatitis C virus (HCV) can induce insulin resistance (IR) in a genotype-dependent fashion, thus contributing to steatosis, progression of fibrosis and resistance to interferon therapy. The molecular mechanisms in genotype 1 patients that lead to metabolic syndrome are still ambiguous. Based on our current understanding, HCV proteins associate with mitochondria and endoplasmic reticulum and promote oxidative stress. The latter mediates signals involving the p38 mitogen-activated protein kinase and activates nuclear factor kappa B. This transcription factor plays a key role in the expression of cytokines, tumor necrosis factor alpha (TNF-alpha), interleukin 6, interleukin 8, tumor growth factor beta, and Fas ligand. TNF-alpha inhibits the function of insulin receptor substrates and decreases the expression of the glucose transporter and lipoprotein lipase in peripheral tissues, which is responsible for the promotion of insulin resistance. Furthermore, reduced adiponectin levels, loss of adiponectin receptors, and decreased anti-inflammatory peroxisome proliferator-activated receptor alpha in the liver of HCV patients may contribute to reduced fatty acid oxidation, inflammation, and eventually lipotoxicity. This chain of events may be initiated by HCV-associated IR and provides a direction for future research in the areas of therapeutic intervention.
C1 [Sheikh, Muhammad Y.] Univ Calif San Francisco, Community Reg Med Ctr, Div Gastroenterol & Hepatol, Fresno Educ Program, Fresno, CA 93721 USA.
   [Choi, Jinah] Univ Calif Merced, Sch Nat Sci, Merced, CA USA.
   [Qadri, Ishtiaq] Natl Ctr Virol & Immunol, Rawalpindi, Pakistan.
   [Qadri, Ishtiaq] Natl Univ Sci & Technol, Rawalpindi, Pakistan.
   [Friedman, Jacob E.] Univ Colorado, Hlth Sci Ctr, Dept Pediat Biochem & Mol Genet, Denver, CO USA.
   [Sanyal, Arun J.] Virginia Commonwealth Univ Hlth Syst, Div Gastroenterol, Richmond, VA USA.
C3 University of California System; University of California San Francisco;
   University of California San Francisco at Fresno; University of
   California System; University of California Merced; National University
   of Sciences & Technology - Pakistan; University of Colorado System;
   University of Colorado Denver; University of Colorado Anschutz Medical
   Campus; Virginia Commonwealth University
RP Sheikh, MY (corresponding author), Univ Calif San Francisco, Community Reg Med Ctr, Div Gastroenterol & Hepatol, Fresno Educ Program, 2823 Fresno St,1st Floor, Fresno, CA 93721 USA.
EM msheikh@fresno.ucsf.edu
RI Qadri, Ishtiaq/I-6889-2013
OI Qadri, Ishtiaq/0000-0003-4334-0585
CR Adachi T, 2005, HEPATOLOGY, V41, P1272, DOI 10.1002/hep.20719
   ALLISON MED, 1994, J HEPATOL, V21, P1135, DOI 10.1016/S0168-8278(05)80631-2
   BASSOLS A, 1988, J BIOL CHEM, V263, P3039
   Bataller R, 2003, J CLIN INVEST, V112, P1383, DOI 10.1172/JCI200318212
   Bièche I, 2005, VIROLOGY, V332, P130, DOI 10.1016/j.virol.2004.11.009
   Bureau C, 2001, J BIOL CHEM, V276, P23077, DOI 10.1074/jbc.M100698200
   Cammà C, 2006, HEPATOLOGY, V43, P64, DOI 10.1002/hep.20983
   Choi J, 2006, AM J PHYSIOL-GASTR L, V290, pG847, DOI 10.1152/ajpgi.00522.2005
   Damcott CM, 2005, DIABETES, V54, P2245, DOI 10.2337/diabetes.54.7.2245
   DeMaria N, 1996, FREE RADICAL BIO MED, V21, P291, DOI 10.1016/0891-5849(96)00044-5
   Dharancy S, 2005, GASTROENTEROLOGY, V128, P334, DOI 10.1053/j.gastro.2004.11.016
   Durante-Mangoni E, 2006, ALIMENT PHARM THERAP, V24, P1349, DOI 10.1111/j.1365-2036.2006.03114.x
   Duvet S, 1998, J BIOL CHEM, V273, P32088, DOI 10.1074/jbc.273.48.32088
   Fartoux L, 2005, GUT, V54, P1003, DOI 10.1136/gut.2004.050302
   Finucane DM, 1999, J BIOL CHEM, V274, P2225, DOI 10.1074/jbc.274.4.2225
   Gong GZ, 2001, P NATL ACAD SCI USA, V98, P9599, DOI 10.1073/pnas.171311298
   GREENBERG AS, 1992, CANCER RES, V52, P4113
   Guerre-Millo M, 2000, J BIOL CHEM, V275, P16638, DOI 10.1074/jbc.275.22.16638
   Haluzík M, 2004, PHYSIOL RES, V53, P123, DOI 10.33549/physiolres.930479
   Hassan M, 2007, CELL SIGNAL, V19, P301, DOI 10.1016/j.cellsig.2006.07.002
   Hotamisligil GS, 1999, J INTERN MED, V245, P621, DOI 10.1046/j.1365-2796.1999.00490.x
   Hourigan LF, 1999, HEPATOLOGY, V29, P1215, DOI 10.1002/hep.510290401
   Hui JM, 2002, J GASTROEN HEPATOL, V17, P873, DOI 10.1046/j.1440-1746.2002.02813.x
   Im SS, 2007, IUBMB LIFE, V59, P134, DOI 10.1080/15216540701313788
   Inoue M, 2005, METABOLISM, V54, P281, DOI 10.1016/j.metabol.2004.09.006
   Korenaga M, 2005, J BIOL CHEM, V280, P37481, DOI 10.1074/jbc.M506412200
   Kota RS, 2005, J BIOL CHEM, V280, P31076, DOI 10.1074/jbc.M412189200
   Lau JYN, 1998, SEMIN LIVER DIS, V18, P169, DOI 10.1055/s-2007-1007152
   LIM HL, 1995, J VIRAL HEPATITIS, V2, P211, DOI 10.1111/j.1365-2893.1995.tb00031.x
   Liu CH, 2003, J BIOL CHEM, V278, P11721, DOI 10.1074/jbc.M207728200
   Machida K, 2006, J VIROL, V80, P7199, DOI 10.1128/JVI.00321-06
   Malaguarnera M, 1997, J GASTROENTEROL, V32, P211, DOI 10.1007/BF02936370
   Matsubara M, 2002, EUR J ENDOCRINOL, V147, P173, DOI 10.1530/eje.0.1470173
   Matsuzaki K, 2007, HEPATOLOGY, V46, P48, DOI 10.1002/hep.21672
   Nakatani Y, 2005, J BIOL CHEM, V280, P847, DOI 10.1074/jbc.M411860200
   Neuman MG, 2007, TRANSL RES, V149, P126, DOI 10.1016/j.trsl.2006.11.002
   Ng TWK, 2005, DIABETES, V54, P795, DOI 10.2337/diabetes.54.3.795
   Ohmura E, 2007, HORM METAB RES, V39, P212, DOI 10.1055/s-2007-970421
   Okuda M, 2002, GASTROENTEROLOGY, V122, P366, DOI 10.1053/gast.2002.30983
   Paik YH, 2003, HEPATOLOGY, V37, P1043, DOI 10.1053/jhep.2003.50182
   Panarotto D, 2002, EUR J CLIN INVEST, V32, P84, DOI 10.1046/j.1365-2362.2002.00945.x
   Pekow JR, 2007, CANCER-AM CANCER SOC, V109, P2490, DOI 10.1002/cncr.22701
   Puri Puneet, 2006, Clin Liver Dis, V10, P793, DOI 10.1016/j.cld.2006.08.002
   Qadri I, 2004, BIOCHEM J, V378, P919, DOI 10.1042/BJ20031587
   Reyes GR, 2002, J BIOMED SCI, V9, P187, DOI 10.1007/BF02256065
   Riordan SM, 2006, INFLAMM RES, V55, P279, DOI 10.1007/s00011-006-0082-0
   Romero-Gómez M, 2005, GASTROENTEROLOGY, V128, P636, DOI 10.1053/j.gastro.2004.12.049
   Steppan CM, 2001, NATURE, V409, P307, DOI 10.1038/35053000
   Suzuki T, 2007, J GASTROENTEROL, V42, P411, DOI 10.1007/s00535-007-2030-3
   Tardif KD, 2002, J VIROL, V76, P7453, DOI 10.1128/JVI.76.15.7453-7459.2002
   Thorén F, 2004, J LEUKOCYTE BIOL, V76, P1180, DOI 10.1189/jlb.0704387
   Yagmur E, 2006, AM J GASTROENTEROL, V101, P1244, DOI 10.1111/j.1572-0241.2006.00543.x
   Zhang D, 2007, CELL DEATH DIFFER, V14, P703, DOI 10.1038/sj.cdd.4402072
NR 53
TC 200
Z9 211
U1 0
U2 14
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0270-9139
J9 HEPATOLOGY
JI Hepatology
PD JUN
PY 2008
VL 47
IS 6
BP 2127
EP 2133
DI 10.1002/hep.22269
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 308LL
UT WOS:000256391500037
PM 18446789
OA Bronze
DA 2025-06-11
ER

PT J
AU Galinier, A
   Carriere, A
   Fernandez, Y
   Caspar-Bauguil, S
   Periquet, B
   Periquet, A
   Penicaud, L
   Casteilla, L
AF Galinier, Anne
   Carriere, Audrey
   Fernandez, Yvette
   Caspar-Bauguil, Sylvie
   Periquet, Brigitte
   Periquet, Alain
   Penicaud, Luc
   Casteilla, Louis
TI Site specific changes of redox metabolism in adipose tissue of obese
   Zucker rats
SO FEBS LETTERS
LA English
DT Article
DE site specificity; adipose tissue; obesity; redox state; glutathione;
   coenzyme Q
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; INSULIN-RESISTANCE;
   HYDROGEN-PEROXIDE; COENZYME-Q; PLASMA; BLOOD; INFLAMMATION; ADIPOCYTES;
   EXPRESSION; STATE
AB Adipose tissues are differently involved in lipid metabolism and obesity according to their type and location. Increasing reports stress on the impact of redox metabolism on obesity and metabolic syndrome. The aim of this work is to investigate the site-specific redox metabolism in three different adipose tissues and its changes occurring in obesity. We analysed enzymatic and non-enzymatic parameters, and focused on the reduced/oxidized glutathione and coenzyme Q couples. In lean compared with obese non-diabetic Zucker rats, interscapular brown fat seems well protected against oxidative stress and epididymal adipose tissue shows a more reduced glutathione redox state, associated with a higher susceptibility to lipophilic oxidative stress than inguinal adipose tissue. Epididymal adipose tissue redox metabolism significantly differs from inguinal one by its limited redox metabolism adaptation. Our results demonstrate site-specific managements of reactive oxygen species metabolism in obese Zucker rats. These results are not consistent with the classic deciphering of inflammatory situation and produce a new conception of the redox parameters implication in the development of the metabolic syndrome. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
C1 CHU Rangueil, Biochim Lab, F-31059 Toulouse 09, France.
   CHU Rangueil, CNRS, IFR 31, UMR 5018,UPS, F-31059 Toulouse 9, France.
C3 CHU de Toulouse; Universite de Toulouse; Universite Toulouse III - Paul
   Sabatier; Universite de Toulouse; Universite Toulouse III - Paul
   Sabatier; CHU de Toulouse; Centre National de la Recherche Scientifique
   (CNRS)
RP Galinier, A (corresponding author), CHU Rangueil, Biochim Lab, 1 Ave Poulhes, F-31059 Toulouse 09, France.
EM galinier.a@chu-toulouse.fr
OI Casteilla, Louis/0000-0001-9647-3248; Galinier,
   Anne/0000-0003-2454-5681; Caspar-Bauguil, Sylvie/0000-0003-2682-0704;
   Carriere, Audrey/0000-0002-4277-7905
CR Ascaso Juan F, 2003, Eur J Intern Med, V14, P101, DOI 10.1016/S0953-6205(03)00022-0
   Atzmon G, 2002, HORM METAB RES, V34, P622, DOI 10.1055/s-2002-38250
   Bjorntorp P, 1996, INT J OBESITY, V20, P291
   Carrière A, 2004, J BIOL CHEM, V279, P40462, DOI 10.1074/jbc.M407258200
   Carrière A, 2003, FEBS LETT, V550, P163, DOI 10.1016/S0014-5793(03)00862-7
   Clairbone A, 1985, HDB METHODS OXYGEN R
   Dandona P, 2004, TRENDS IMMUNOL, V25, P4, DOI 10.1016/j.it.2003.10.013
   DEGIROLAMO M, 1998, AM J PHYSIOL, V274, pR1460
   Echtay KS, 2000, NATURE, V408, P609, DOI 10.1038/35046114
   Faure P, 2004, EUR J CLIN INVEST, V34, P475, DOI 10.1111/j.1365-2362.2004.01362.x
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Galinier A, 2006, J BIOL CHEM, V281, P12682, DOI 10.1074/jbc.M506949200
   Galinier A, 2004, FEBS LETT, V578, P53, DOI 10.1016/j.febslet.2004.10.067
   Giusti V, 2004, J CLIN ENDOCR METAB, V89, P1379, DOI 10.1210/jc.2003-031507
   GUNZLER WA, 1974, Z KLIN CHEM KLIN BIO, V12, P444
   HARVEY PRC, 1989, CLIN CHIM ACTA, V180, P203, DOI 10.1016/0009-8981(89)90001-6
   HASSAN HM, 1979, ARCH BIOCHEM BIOPHYS, V196, P385, DOI 10.1016/0003-9861(79)90289-3
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   MARKLUND S, 1974, EUR J BIOCHEM, V47, P469
   McClung JP, 2004, P NATL ACAD SCI USA, V101, P8852, DOI 10.1073/pnas.0308096101
   Melnyk S, 1999, J NUTR BIOCHEM, V10, P490, DOI 10.1016/S0955-2863(99)00033-9
   NegreSalvayre A, 1997, FASEB J, V11, P809, DOI 10.1096/fasebj.11.10.9271366
   Park J, 2005, MOL CELL BIOL, V25, P5146, DOI 10.1128/MCB.25.12.5146-5157.2005
   Prunet-Marcassus B, 1999, FEBS LETT, V464, P184, DOI 10.1016/S0014-5793(99)01710-X
   Rajala MW, 2003, ENDOCRINOLOGY, V144, P3765, DOI 10.1210/en.2003-0580
   Reitman A, 2002, ISRAEL MED ASSOC J, V4, P590
   Schafer FQ, 2001, FREE RADICAL BIO MED, V30, P1191, DOI 10.1016/S0891-5849(01)00480-4
   SPEEK AJ, 1984, J CHROMATOGR, V305, P53, DOI 10.1016/S0378-4347(00)83313-7
   Touyz RM, 2004, HISTOCHEM CELL BIOL, V122, P339, DOI 10.1007/s00418-004-0696-7
   Turrens JF, 2003, J PHYSIOL-LONDON, V552, P335, DOI 10.1113/jphysiol.2003.049478
   Wajchenberg BL, 2000, ENDOCR REV, V21, P697, DOI 10.1210/er.21.6.697
   Wang MY, 2005, P NATL ACAD SCI USA, V102, P18011, DOI 10.1073/pnas.0509001102
   YAGI K, 1984, METHOD ENZYMOL, V105, P328
   Yang SQ, 2000, ARCH BIOCHEM BIOPHYS, V378, P259, DOI 10.1006/abbi.2000.1829
NR 35
TC 31
Z9 34
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-5793
EI 1873-3468
J9 FEBS LETT
JI FEBS Lett.
PD NOV 27
PY 2006
VL 580
IS 27
BP 6391
EP 6398
DI 10.1016/j.febslet.2006.10.052
PG 8
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 114KS
UT WOS:000242665700016
PM 17098232
OA Bronze
DA 2025-06-11
ER

PT J
AU Park, S
   Choi, NK
AF Park, Sangshin
   Choi, Nam-Kyong
TI Breastfeeding reduces risk of depression later in life in the
   postmenopausal period: A Korean population-based study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Breastfeeding; Lactation; Depression; The Patient Health Questionnaire 9
ID POSTPARTUM DEPRESSION; METABOLIC SYNDROME; VALIDITY
AB Objective: The relationship between breastfeeding and maternal depression in later life has not yet been investigated. We examined whether the number of breastfed infants or the period of breastfeeding influenced maternal depression in postmenopausal women.
   Methods: We analyzed 1,372 parous postmenopausal women aged >= 50 years who had participated in the Korea National Health and Nutrition Examination Survey 2014. Depression was diagnosed using the Patient Health Questionnaire 9, with scores of 10 or higher indicating depression. Logistic regression analyses were performed to examine the relationships between breastfeeding and postmenopausal depression.
   Results: Women with a moderate (2-3) or high (4-12) number of breastfed infants had 65% [odds ratio (OR) = 0.35, 95% confidence interval (CI) = 0.19-0.65] and 77% (OR = 0.23, 95% CI = 0.10-0.55) decreased risks of depression, respectively, compared to those with low numbers of infants (0-1). Women who breastfed their infants for long periods (47-432 months) had 67% (OR = 0.33, 95% CI = 0.16-0.68) decreased risk of depression, compared to those who breastfed for short periods (0-23 months). The risk of depression decreased by 29% (OR = 0.71, 95% CI = 0.58-0.87) for each additional infant breastfed and by 9% (OR = 0.91, 95% CI = 0.82- < 1.00) for each additional year of breastfeeding. The population-attributable fraction of depression associated with < 2 infants breastfed was 17.3% (95% CI = 14.2-20.3%), while the fraction associated with a period of breastfeeding < 24 months was not significant.
   Conclusions: Women with more breastfed infants or longer period of breastfeeding are at decreased risk of depression in the postmenopausal period.
C1 [Park, Sangshin] Brown Univ, Rhode Isl Hosp, Ctr Int Hlth Res, Warren Alpert Med Sch, Providence, RI 02903 USA.
   [Park, Sangshin] Brown Univ, Dept Pediat, Warren Alpert Med Sch, Providence, RI 02912 USA.
   [Park, Sangshin] Univ Seoul, Grad Sch Urban Publ Hlth, Seoul, South Korea.
   [Choi, Nam-Kyong] Ewha Womans Univ, Dept Hlth Convergence, 52 Ewhayeodae Gil, Seoul 03760, South Korea.
C3 Lifespan Health Rhode Island; Rhode Island Hospital; Brown University;
   Brown University; University of Seoul; Ewha Womans University
RP Choi, NK (corresponding author), Ewha Womans Univ, Dept Hlth Convergence, 52 Ewhayeodae Gil, Seoul 03760, South Korea.
EM nchoi@ewha.ac.kr
RI Park, Sangshin/K-6889-2014
OI Park, Sangshin/0000-0003-2407-0962
CR [Anonymous], 2009, INF YOUNG CHILD FEED
   [Anonymous], 2004, PROTECTION PROMOTION
   Borra C, 2015, MATERN CHILD HLTH J, V19, P897, DOI 10.1007/s10995-014-1591-z
   Britton JR, 2006, PEDIATRICS, V118, pE1436, DOI 10.1542/peds.2005-2916
   Butte NF, 2005, PUBLIC HEALTH NUTR, V8, P1010, DOI 10.1079/PHN2005793
   CDC, 2018, US CTR DIS CONTR NAT
   Dias CC, 2015, J AFFECT DISORDERS, V171, P142, DOI 10.1016/j.jad.2014.09.022
   Domes G, 2016, BMC PSYCHIATRY, V16, DOI 10.1186/s12888-016-0794-9
   Eidelman AI, 2012, PEDIATRICS, V129, pE827, DOI 10.1542/peds.2011-3552
   Fergusson DM, 1999, PAEDIATR PERINAT EP, V13, P144
   Fox M, 2013, J ALZHEIMERS DIS, V37, P809, DOI 10.3233/JAD-130152
   Hamdan A, 2012, INT J PSYCHIAT MED, V43, P243, DOI 10.2190/PM.43.3.d
   Han CS, 2008, COMPR PSYCHIAT, V49, P218, DOI 10.1016/j.comppsych.2007.08.006
   Handlin L, 2009, BREASTFEED MED, V4, P207, DOI 10.1089/bfm.2009.0001
   Heeringa SG, 2015, ANN EPIDEMIOL, V25, P174, DOI 10.1016/j.annepidem.2014.11.007
   Heinrichs M, 2001, J CLIN ENDOCR METAB, V86, P4798, DOI 10.1210/jc.86.10.4798
   Kendall-Tackett K, 2007, INT BREASTFEED J, V2, DOI 10.1186/1746-4358-2-6
   Kim S, 2016, NEW DIR CHILD ADOLES, V153, P59, DOI 10.1002/cad.20170
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Li RW, 2005, NUTR REV, V63, P103, DOI 10.1111/j.1753-4887.2005.tb00128.x
   Moura D, 2016, ARCH WOMEN MENT HLTH, V19, P561, DOI 10.1007/s00737-016-0643-3
   Oh SW, 2004, OBES RES, V12, P2031, DOI 10.1038/oby.2004.254
   Organization W.H., 2017, Depression and other common mental disorders: Global health estimates
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Park S, 2018, AM J HYPERTENS, V31, P615, DOI 10.1093/ajh/hpx219
   Schwarz EB, 2009, OBSTET GYNECOL, V113, P974, DOI 10.1097/01.AOG.0000346884.67796.ca
   Schwarze CE, 2015, J PERS DISORD, V29, P610, DOI 10.1521/pedi_2014_28_160
   Stuebe AM, 2015, SEMIN PERINATOL, V39, P290, DOI 10.1053/j.semperi.2015.05.008
   Victora CG, 2016, LANCET, V387, P475, DOI 10.1016/S0140-6736(15)01024-7
   Wang TG, 2016, AM J EPIDEMIOL, V184, P295, DOI 10.1093/aje/kwv326
   Yen JY, 2009, PSYCHIAT CLIN NEUROS, V63, P678, DOI 10.1111/j.1440-1819.2009.02001.x
   Yusuff ASM, 2016, J HUM LACT, V32, P277, DOI 10.1177/0890334415620788
   Zhang Hai, 2013, PLoS One, V8, pe61477, DOI 10.1371/journal.pone.0061477
   Zheng YJ, 2017, SCI REP-UK, V7, DOI 10.1038/srep46453
NR 34
TC 4
Z9 4
U1 0
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD APR 1
PY 2019
VL 248
BP 13
EP 17
DI 10.1016/j.jad.2018.12.081
PG 5
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA HL4MQ
UT WOS:000458696300002
PM 30708102
DA 2025-06-11
ER

PT J
AU Lee, YL
   Lin, KL
   Wu, BN
   Chuang, SM
   Wu, WJ
   Lee, YC
   Ho, WT
   Juan, YS
AF Lee, Yi-Lun
   Lin, Kun-Ling
   Wu, Bin-Nan
   Chuang, Shu-Mien
   Wu, Wen-Jeng
   Lee, Yung-Chin
   Ho, Wan-Ting
   Juan, Yung-Shun
TI Epigallocatechin-3-gallate alleviates bladder overactivity in a rat
   model with metabolic syndrome and ovarian hormone deficiency through
   mitochondria apoptosis pathways
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; GREEN TEA CATECHINS; OXIDATIVE STRESS;
   CELL-DEATH; MENOPAUSE; NEUROPROTECTION; HYPERGLYCEMIA; POLYPHENOLS;
   MODULATION; ACTIVATION
AB Metabolic syndrome (MetS) and ovarian hormone deficiency could affect bladder storage dysfunction. Epigallocatechin-3-gallate (EGCG), a polyphenolic compound in green tea, has been shown to protect against ovarian hormone deficiency induced overactive bladder (OAB). The present study investigated oxidative stress induced by MetS and bilateral ovariectomy (OVX), and elucidated the mechanism underlying the protective effect of EGCG (10 umol/kg/day) on bladder overactivity. Rats were fed with high fat high sugar (HFHS) diet to induce MetS and received ovariectomy surgery to deprive ovarian hormone. By dieting with HFHS for 6 months, rats developed MetS and OAB. MetS + OVX deteriorated bladder storage dysfunction more profound than MetS alone. MetS and MetS + OVX rats showed over-expression of inflammatory and fibrosis markers (1.7 similar to 3.8-fold of control). EGCG pretreatment alleviated storage dysfunction, and protected the bladders from MetS and OVX - induced interstitial fibrosis changes. Moreover, OVX exacerbated MetS related bladder apoptosis (2.3 similar to 4.5-fold of control; 1.8 similar to 2.6-fold of Mets group), enhances oxidative stress markers (3.6 similar to 4.3-fold of control; 1.8 similar to 2.2-fold of Mets group) and mitochondrial enzyme complexes subunits (1.8 similar to 3.7-fold of control; 1.5 similar to 3.4-fold of Mets group). EGCG pretreatment alleviated bladder apoptosis, attenuated oxidative stress, and reduced the mitochondrial and endoplasmic reticulum apoptotic signals. In conclusions, HFHS feeding and ovarian hormone deficiency enhances the generation of oxidative stress mediated through mitochondrial pathway. EGCG reduced the generation of oxidative stress and lessened bladder overactivity.
C1 [Lee, Yi-Lun; Wu, Bin-Nan; Wu, Wen-Jeng; Juan, Yung-Shun] Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan.
   [Lee, Yi-Lun] Minist Hlth & Welf, Sinying Hosp, Dept Urol, Tainan, Taiwan.
   [Lin, Kun-Ling] Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung, Taiwan.
   [Lin, Kun-Ling] Kaohsiung Med Univ Hosp, Dept Obstet & Gynecol, Kaohsiung, Taiwan.
   [Wu, Bin-Nan] Kaohsiung Med Univ, Coll Med, Dept Pharmacol, Kaohsiung, Taiwan.
   [Chuang, Shu-Mien] Kaohsiung Med Univ, Dept Med Res, Canc Ctr, Translat Res Ctr, Kaohsiung, Taiwan.
   [Wu, Wen-Jeng; Lee, Yung-Chin; Ho, Wan-Ting; Juan, Yung-Shun] Kaohsiung Med Univ, Coll Med, Dept Urol, Kaohsiung, Taiwan.
   [Wu, Wen-Jeng; Lee, Yung-Chin; Ho, Wan-Ting; Juan, Yung-Shun] Kaohsiung Med Univ Hosp, Dept Urol, Kaohsiung, Taiwan.
   [Wu, Wen-Jeng; Juan, Yung-Shun] Kaohsiung Municipal Tatung Hosp, Dept Urol, Kaohsiung, Taiwan.
   [Lee, Yung-Chin] Kaohsiung Municipal Hsiaokang Hosp, Dept Urol, Kaohsiung, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University; Kaohsiung
   Medical University; Kaohsiung Medical University Hospital; Kaohsiung
   Medical University; Kaohsiung Medical University; Kaohsiung Medical
   University; Kaohsiung Medical University; Kaohsiung Medical University
   Hospital; Kaohsiung Medical University; Kaohsiung Municipal Ta-Tung
   Hospital; Kaohsiung Medical University; Kaohsiung Municipal Siao-Gang
   Hospital
RP Juan, YS (corresponding author), Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan.; Juan, YS (corresponding author), Kaohsiung Med Univ, Coll Med, Dept Urol, Kaohsiung, Taiwan.; Juan, YS (corresponding author), Kaohsiung Med Univ Hosp, Dept Urol, Kaohsiung, Taiwan.; Juan, YS (corresponding author), Kaohsiung Municipal Tatung Hosp, Dept Urol, Kaohsiung, Taiwan.
EM juanuro@gmail.com
RI Lee, Yung-Chin/A-2027-2010; Wu, Wen-Jeng/C-7267-2009; Wu,
   Bin-Nan/ITV-0893-2023
OI wu, wen jeng/0000-0002-9691-7416
FU Ministry of Science and Technology [NSC-105-2314-B-037-043-MY3];
   Department of Medical Research, Kaohsiung Medical University Hospital
   grant [KMUH-104-4R45, KMUH-105-5R44, KMUH -106-6R60]; Kaohsiung
   Kaohsiung Municipal Hsiao-Kang Hospital grant [Kmhk-103-021,
   Kmhk-104-021]; Ministry of Health and Welfare [MOHW103-TD-B-111-05]
FX We are grateful to Professor Chang-Hwei Chen of the University at
   Albany, State University of New York for his valuable comments on this
   manuscript. Grant numbers and sources of support: This research is
   supported by the grant from the Ministry of Science and Technology
   (NSC-105-2314-B-037-043-MY3), in part by the Department of Medical
   Research, Kaohsiung Medical University Hospital grant (KMUH-104-4R45,
   KMUH-105-5R44, KMUH -106-6R60) in part by Kaohsiung Kaohsiung Municipal
   Hsiao-Kang Hospital grant (Kmhk-103-021, Kmhk-104-021) and Ministry of
   Health and Welfare (MOHW103-TD-B-111-05).
CR Baell J, 2014, NATURE, V513, P481, DOI 10.1038/513481a
   Boudina S, 2007, DIABETES, V56, P2457, DOI 10.2337/db07-0481
   Brownlee M, 2005, DIABETES, V54, P1615, DOI 10.2337/diabetes.54.6.1615
   Cannon TW, 2001, LIFE SCI, V69, P1193
   Cheng CL, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000004107
   Chuang SM, 2013, MENOPAUSE, V20, P209, DOI 10.1097/gme.0b013e3182635bae
   Chung SD, 2013, EUR J NUTR, V52, P347, DOI 10.1007/s00394-012-0342-4
   Coyle CH, 2008, LIFE SCI, V83, P12, DOI 10.1016/j.lfs.2008.04.010
   Dey A, 2010, LIFE SCI, V87, P197, DOI 10.1016/j.lfs.2010.06.007
   Elezaby A, 2015, J MOL CELL CARDIOL, V79, P275, DOI 10.1016/j.yjmcc.2014.12.001
   Eshtiaghi R, 2010, MATURITAS, V65, P262, DOI 10.1016/j.maturitas.2009.11.004
   Gaspard U, 2009, MATURITAS, V62, P362, DOI 10.1016/j.maturitas.2008.11.026
   Gorbachinsky Ilya, 2010, Rev Urol, V12, pe157
   Green DR, 2004, SCIENCE, V305, P626, DOI 10.1126/science.1099320
   Hitomi J, 2004, J CELL BIOL, V165, P347, DOI 10.1083/jcb.200310015
   Iwata Atsushi, 2006, J Cardiol, V47, P1
   Juan YS, 2012, BJU INT, V110, pE236, DOI 10.1111/j.1464-410X.2012.11258.x
   Juan YS, 2012, MENOPAUSE, V19, P346, DOI 10.1097/gme.0b013e31822d652d
   Kim R, 2006, APOPTOSIS, V11, P5, DOI 10.1007/s10495-005-3088-0
   Levites Y, 2002, BIOCHEM PHARMACOL, V63, P21, DOI 10.1016/S0006-2952(01)00813-9
   Levites Y, 2001, J NEUROCHEM, V78, P1073, DOI 10.1046/j.1471-4159.2001.00490.x
   Liu GG, 2008, BIOCHEM BIOPH RES CO, V370, P651, DOI 10.1016/j.bbrc.2008.04.031
   Liu H, 2005, J AM SOC NEPHROL, V16, P1985, DOI 10.1681/ASN.2004090768
   Liu KM, 2015, AM J PHYSIOL-RENAL, V309, pF318, DOI 10.1152/ajprenal.00607.2014
   Mandel SA, 2005, NEUROSIGNALS, V14, P46, DOI 10.1159/000085385
   Manohar M, 2013, J NUTR BIOCHEM, V24, P940, DOI 10.1016/j.jnutbio.2012.06.013
   Michel MC, 2015, N-S ARCH PHARMACOL, V388, P687, DOI 10.1007/s00210-015-1137-y
   Michel MC, 2015, ANNU REV PHARMACOL, V55, P269, DOI 10.1146/annurev-pharmtox-010814-124536
   Miller A, 2008, CURR OPIN GASTROEN, V24, P204, DOI 10.1097/MOG.0b013e3282f3f4c4
   Nomiya M, 2012, NEUROUROL URODYNAM, V31, P185, DOI 10.1002/nau.21191
   Ohse T, 2006, KIDNEY INT, V70, P1447, DOI 10.1038/sj.ki.5001704
   Oyadomari S, 2004, CELL DEATH DIFFER, V11, P381, DOI 10.1038/sj.cdd.4401373
   Pan MH, 2000, BIOCHEM PHARMACOL, V59, P357, DOI 10.1016/S0006-2952(99)00335-4
   Peinado JR, 2014, PROTEOMICS, V14, P452, DOI 10.1002/pmic.201300376
   Qanungo S, 2005, CARCINOGENESIS, V26, P958, DOI 10.1093/carcin/bgi040
   Robinson D, 2003, UROLOGY, V62, P45, DOI 10.1016/S0090-4295(03)00676-9
   Rolo AP, 2006, TOXICOL APPL PHARM, V212, P167, DOI 10.1016/j.taap.2006.01.003
   Sazuka M, 1998, BIOSCI BIOTECH BIOCH, V62, P1031, DOI 10.1271/bbb.62.1031
   Sverdlov AL, 2015, J MOL CELL CARDIOL, V78, P165, DOI 10.1016/j.yjmcc.2014.07.018
   Thurmond P, 2016, AM J PHYSIOL-RENAL, V310, pF738, DOI 10.1152/ajprenal.00333.2015
   Uzun H, 2012, INT NEUROUROL J, V16, P181, DOI 10.5213/inj.2012.16.4.181
   Uzun H, 2012, UROLOGY, V79, P72, DOI 10.1016/j.urology.2011.08.050
   Wallace DC, 2005, ANNU REV GENET, V39, P359, DOI 10.1146/annurev.genet.39.110304.095751
   Weinreb O, 2003, FASEB J, V17, P935, DOI 10.1096/fj.02-0712fje
   Yu HJ, 2006, UROL INT, V77, P327, DOI 10.1159/000096337
   Yu TZ, 2008, CARDIOVASC RES, V79, P341, DOI 10.1093/cvr/cvn104
NR 46
TC 19
Z9 19
U1 0
U2 6
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 29
PY 2018
VL 8
AR 5358
DI 10.1038/s41598-018-23800-w
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GA8VI
UT WOS:000428618900001
PM 29599473
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yan, YX
   Xiao, HB
   Wang, SS
   Zhao, J
   He, Y
   Wang, W
   Dong, J
AF Yan, Yu-Xiang
   Xiao, Huan-Bo
   Wang, Si-Si
   Zhao, Jing
   He, Yan
   Wang, Wei
   Dong, Jing
TI Investigation of the Relationship Between Chronic Stress and Insulin
   Resistance in a Chinese Population
SO JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE stress; insulin resistance; cortisol; HOMA-IR
ID SUBOPTIMAL HEALTH-STATUS; METABOLIC SYNDROME; GLUCOSE; DISEASE; RISK;
   ASSOCIATION; MECHANISMS; MEDIATORS; CORTISOL; WORK
AB Background: Chronic stress may facilitate the development of metabolic diseases. Insulin resistance is present long before the clinical manifestations of individual metabolic abnormalities. To explore whether chronic stress is an independent risk factor of insulin resistance, we investigated the relationship between the stress system, selected parameters of energy homeostasis, and insulin resistance in a Chinese population.
   Methods: We recruited 766 workers employed at four companies in Beijing. The degree of insulin resistance was determined using the homeostasis model assessment of insulin resistance (HOMA-IR). The highest quartile of HOMA-IR among all study subjects was further defined as insulin resistance in our study. The short standard version of the Copenhagen Psychosocial Questionnaire (COPSOQ) was used to assess job-related psychosocial stress. Pearson's correlation coefficients were calculated between cortisol level and HOMA-IR and components of metabolic syndrome, with stratification by gender. The relationship between cortisol and HOMA-IR independent of obesity was analyzed using a linear mixed model with company as a cluster unit.
   Results: The values of the two scales of COPSOQ, including "demands at work" and "insecurity at work", were significantly associated with insulin resistance and cortisol concentration (P < 0.05). Cortisol was significantly positively correlated with glucose, HOMA-IR, and waist circumference in males and females (P < 0.05). After adjusting for potential confounders, cortisol was an independent positive predictor for HOMA-IR (P < 0.05).
   Conclusions: These findings showed that chronic stress was associated with insulin resistance and may contribute to the development of insulin resistance.
C1 [Yan, Yu-Xiang; Wang, Si-Si; He, Yan; Wang, Wei] Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing, Peoples R China.
   [Yan, Yu-Xiang; He, Yan; Wang, Wei] Municipal Key Lab Clin Epidemiol, Beijing, Peoples R China.
   [Xiao, Huan-Bo] Capital Med Univ, Yanjing Med Coll, Dept Prevent Med, Beijing, Peoples R China.
   [Zhao, Jing; Dong, Jing] Capital Med Univ, Xuanwu Hosp, Hlth Med Examinat Ctr, 45 Changchun St, Beijing 100053, Peoples R China.
   [Wang, Wei] Edith Cowan Univ, Sch Med Sci, Perth, WA, Australia.
C3 Capital Medical University; Capital Medical University; Capital Medical
   University; Edith Cowan University
RP Dong, J (corresponding author), Capital Med Univ, Xuanwu Hosp, Hlth Med Examinat Ctr, 45 Changchun St, Beijing 100053, Peoples R China.
EM dongjingepi@163.com
RI Wang, Anxin/AAD-4073-2021; Dong, Jing/KDM-6171-2024
FU National Natural Science Foundation [81573214]; Scientific Research
   Common Program of Beijing Municipal Commission of Education
   [KM201510025006]; Importation and Development of High-Caliber Talents
   Project of Beijing Municipal Institutions [CITTCD201304181]; National
   Science and Technology Support Program [2012BAI37B03]
FX This study was supported by the National Natural Science Foundation
   (81573214), the Scientific Research Common Program of Beijing Municipal
   Commission of Education (KM201510025006), the Importation and
   Development of High-Caliber Talents Project of Beijing Municipal
   Institutions (CIT&TCD201304181), and the National Science and Technology
   Support Program (2012BAI37B03).
CR Barthel A, 2003, MED KLIN, V98, P283, DOI 10.1007/s00063-003-1258-9
   Binnert C, 2004, DIABETES METAB, V30, P321, DOI 10.1016/S1262-3636(07)70123-4
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   Burén J, 2005, DIABETES-METAB RES, V21, P487, DOI 10.1002/dmrr.567
   CARO JF, 1991, J CLIN ENDOCR METAB, V73, P691, DOI 10.1210/jcem-73-4-691
   Eller NH, 2006, BIOL PSYCHOL, V73, P280, DOI 10.1016/j.biopsycho.2006.05.003
   Kristensen TS, 2005, SCAND J WORK ENV HEA, V31, P438, DOI 10.5271/sjweh.948
   Li L, 2012, PUBLIC HEALTH, V126, P210, DOI 10.1016/j.puhe.2011.11.012
   Lundgren M, 2004, J CLIN ENDOCR METAB, V89, P2989, DOI 10.1210/jc.2003-031157
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McEwen BS, 2008, EUR J PHARMACOL, V583, P174, DOI 10.1016/j.ejphar.2007.11.071
   Monzillo LU, 2003, NUTR REV, V61, P397, DOI 10.1301/nr.2003.dec.397-412
   Nicod N, 2003, OBES RES, V11, P625, DOI 10.1038/oby.2003.90
   Novelli M, 2008, DIABETES-METAB RES, V24, P155, DOI 10.1002/dmrr.785
   Shang Li Shang Li, 2008, Journal of Environmental & Occupational Medicine, V25, P572
   Sjöstrand M, 2009, MOL CELL ENDOCRINOL, V297, P104, DOI 10.1016/j.mce.2008.05.010
   Tamashiro KL, 2011, STRESS, V14, P468, DOI 10.3109/10253890.2011.606341
   Ware WR, 2008, MED HYPOTHESES, V71, P45, DOI 10.1016/j.mehy.2008.02.008
   Yan YX, 2012, J URBAN HEALTH, V89, P329, DOI 10.1007/s11524-011-9636-8
   Yan YX, 2015, STRESS, V18, P29, DOI 10.3109/10253890.2014.999233
   Yan YX, 2014, ENDOCRINE, V47, P740, DOI 10.1007/s12020-014-0324-9
NR 21
TC 42
Z9 48
U1 0
U2 8
PU JAPAN EPIDEMIOLOGICAL ASSOC
PI TOKYO
PA C/O UNIBO PRESS, HONGO MT BLDG 4F, 7-2-2 HONGO, BUNKYO-KU, TOKYO,
   113-0033, JAPAN
SN 0917-5040
EI 1349-9092
J9 J EPIDEMIOL
JI J. Epidemiol.
PD JUL
PY 2016
VL 26
IS 7
BP 355
EP 360
DI 10.2188/jea.JE20150183
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA DR2PC
UT WOS:000379745400004
PM 26830350
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Copeland, WE
   Wolke, D
   Lereya, ST
   Shanahan, L
   Worthman, C
   Costello, EJ
AF Copeland, William E.
   Wolke, Dieter
   Lereya, Suzet Tanya
   Shanahan, Lilly
   Worthman, Carol
   Costello, E. Jane
TI Childhood bullying involvement predicts low-grade systemic inflammation
   into adulthood
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE stress; social functioning; longitudinal; risk factor; epidemiology
ID C-REACTIVE PROTEIN; PHYSIOLOGICAL STRESS-RESPONSE;
   CORONARY-HEART-DISEASE; SOCIOECONOMIC-STATUS; CARDIOVASCULAR-DISEASE;
   PSYCHIATRIC-DISORDERS; PEER VICTIMIZATION; METABOLIC SYNDROME;
   RISK-FACTORS; BLOOD SPOTS
AB Bullying is a common childhood experience that involves repeated mistreatment to improve or maintain one's status. Victims display long-term social, psychological, and health consequences, whereas bullies display minimal ill effects. The aim of this study is to test how this adverse social experience is biologically embedded to affect short- r long-term levels of C-reactive protein (CRP), a marker of low-grade systemic inflammation. The prospective population-based Great Smoky Mountains Study (n = 1,420), with up to nine waves of data per subject, was used, covering childhood/adolescence (ages 9-16) and young adulthood (ages 19 and 21). Structured interviews were used to assess bullying involvement and relevant covariates at all childhood/adolescent observations. Blood spots were collected at each observation and assayed for CRP levels. During childhood and adolescence, the number of waves at which the child was bullied predicted increasing levels of CRP. Although CRP levels rose for all participants from childhood into adulthood, being bullied predicted greater increases in CRP levels, whereas bullying others predicted lower increases in CRP compared with those uninvolved in bullying. This pattern was robust, controlling for body mass index, substance use, physical and mental health status, and exposures to other childhood psychosocial adversities. A child's role in bullying may serve as either a risk or a protective factor for adult low-grade inflammation, independent of other factors. Inflammation is a physiological response that mediates the effects of both social adversity and dominance on decreases in health.
C1 [Copeland, William E.; Costello, E. Jane] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27713 USA.
   [Wolke, Dieter; Lereya, Suzet Tanya] Univ Warwick, Dept Psychol, Coventry CV4 7AL, W Midlands, England.
   [Wolke, Dieter; Lereya, Suzet Tanya] Univ Warwick, Div Mental Hlth & Wellbeing, Coventry CV4 7AL, W Midlands, England.
   [Shanahan, Lilly] Univ N Carolina, Dept Psychol, Chapel Hill, NC 27599 USA.
   [Worthman, Carol] Emory Univ, Dept Anthropol, Atlanta, GA 30322 USA.
C3 Duke University; University of Warwick; University of Warwick;
   University of North Carolina; University of North Carolina Chapel Hill;
   Emory University
RP Copeland, WE (corresponding author), Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27713 USA.
EM william.copeland@duke.edu
RI Shanahan, Lilly/HNJ-6173-2023; Wolke, Dieter/C-5372-2008; Copeland,
   William E/N-5413-2014
OI Worthman, Carol M/0000-0002-5397-2298; Wolke,
   Dieter/0000-0003-0304-268X; Lereya, Suzet Tanya/0000-0001-9100-459X;
   Copeland, William E/0000-0002-1348-7781; Shanahan,
   Lilly/0000-0002-4534-6924
FU National Institute of Mental Health [MH63970, MH63671, MH48085,
   MH080230]; National Institute on Drug Abuse [DA/MH11301, DA023026];
   National Alliance for Research on Schizophrenia and Depression; William
   T. Grant Foundation; Economic and Social Research Council in the United
   Kingdom [ES/K003593/1]; ESRC [ES/K003593/1] Funding Source: UKRI
FX This work was supported by the National Institute of Mental Health
   (MH63970, MH63671, MH48085, and MH080230), the National Institute on
   Drug Abuse (DA/MH11301 and DA023026), the National Alliance for Research
   on Schizophrenia and Depression (Early Career Award to W. E. C.), the
   William T. Grant Foundation, and the Economic and Social Research
   Council in the United Kingdom (ES/K003593/1).
CR ACHENBACH TM, 1987, PSYCHOL BULL, V101, P213, DOI 10.1037/0033-2909.101.2.213
   Alley DE, 2006, BRAIN BEHAV IMMUN, V20, P498, DOI 10.1016/j.bbi.2005.10.003
   Angold A, 2000, J AM ACAD CHILD PSY, V39, P39, DOI 10.1097/00004583-200001000-00015
   Ascher BH, 1996, J EMOT BEHAV DISORD, V4, P12, DOI 10.1177/106342669600400102
   Copeland W, 2011, J AM ACAD CHILD PSY, V50, P252, DOI 10.1016/j.jaac.2010.12.014
   Copeland WE, 2013, JAMA PSYCHIAT, V70, P419, DOI 10.1001/jamapsychiatry.2013.504
   Costello EJ, 1996, ARCH GEN PSYCHIAT, V53, P1129
   Costello EJ, 2003, ARCH GEN PSYCHIAT, V60, P837, DOI 10.1001/archpsyc.60.8.837
   Dai J, 2008, CIRCULATION, V117, P169, DOI 10.1161/CIRCULATIONAHA.107.710699
   Danese A, 2011, MOL PSYCHIATR, V16, P244, DOI 10.1038/mp.2010.5
   Danese A, 2008, ARCH GEN PSYCHIAT, V65, P409, DOI 10.1001/archpsyc.65.4.409
   Danese A, 2007, P NATL ACAD SCI USA, V104, P1319, DOI 10.1073/pnas.0610362104
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   Elovainio M, 2006, PSYCHOL MED, V36, P797, DOI 10.1017/S0033291706007574
   Finkelhor D, 2007, DEV PSYCHOPATHOL, V19, P149, DOI 10.1017/S0954579407070083
   Forero R, 1999, BRIT MED J, V319, P344, DOI 10.1136/bmj.319.7206.344
   Gimeno D, 2009, PSYCHOL MED, V39, P413, DOI 10.1017/S0033291708003723
   Gini G, 2009, PEDIATRICS, V123, P1059, DOI 10.1542/peds.2008-1215
   Hamilton LD, 2008, PHYSIOL BEHAV, V95, P617, DOI 10.1016/j.physbeh.2008.09.001
   Hansen ÅM, 2006, J PSYCHOSOM RES, V60, P63, DOI 10.1016/j.jpsychores.2005.06.078
   Jansen DEMC, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-440
   Jousilahti P, 2003, J EPIDEMIOL COMMUN H, V57, P730, DOI 10.1136/jech.57.9.730
   Juvonen J, 2003, PEDIATRICS, V112, P1231, DOI 10.1542/peds.112.6.1231
   Kaptoge S, 2010, LANCET, V375, P132, DOI 10.1016/S0140-6736(09)61717-7
   Knack JM, 2011, BRAIN COGNITION, V77, P183, DOI 10.1016/j.bandc.2011.06.011
   Koster A, 2006, J GERONTOL A-BIOL, V61, P284, DOI 10.1093/gerona/61.3.284
   Kumpulainen K, 1998, CHILD ABUSE NEGLECT, V22, P705, DOI 10.1016/S0145-2134(98)00049-0
   Loucks EB, 2006, AM J EPIDEMIOL, V163, P622, DOI 10.1093/aje/kwj076
   McDade TW, 2006, PSYCHOSOM MED, V68, P376, DOI 10.1097/01.psy.0000221371.43607.64
   McDade TW, 2000, PSYCHOSOM MED, V62, P560, DOI 10.1097/00006842-200007000-00015
   McDade TW, 2005, AM J PHYS ANTHROPOL, V128, P906, DOI 10.1002/ajpa.20222
   McDade TW, 2004, CLIN CHEM, V50, P652, DOI 10.1373/clinchem.2003.029488
   Mei JV, 2001, J NUTR, V131, p1631S, DOI 10.1093/jn/131.5.1631S
   Moyna NM, 1999, INT J SPORTS MED, V20, P136, DOI 10.1055/s-2007-971107
   O'Connor MF, 2009, BRAIN BEHAV IMMUN, V23, P887, DOI 10.1016/j.bbi.2009.04.005
   Ouellet-Morin I, 2013, PSYCHOL MED, V43, P1813, DOI 10.1017/S0033291712002784
   Ouellet-Morin I, 2011, BIOL PSYCHIAT, V70, P1016, DOI 10.1016/j.biopsych.2011.06.017
   Ouellet-Morin I, 2011, J AM ACAD CHILD PSY, V50, P574, DOI 10.1016/j.jaac.2011.02.015
   Pearson TA, 2003, CIRCULATION, V107, P499, DOI 10.1161/01.CIR.0000052939.59093.45
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Radford L, 2013, CHILD ABUSE NEGLECT, V37, P801, DOI 10.1016/j.chiabu.2013.02.004
   Raison CL, 2006, TRENDS IMMUNOL, V27, P24, DOI 10.1016/j.it.2005.11.006
   Reijntjes A, 2013, J ABNORM CHILD PSYCH, V41, P1217, DOI 10.1007/s10802-013-9759-3
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   Ronning JA, 2009, SOC PSYCH PSYCH EPID, V44, P15, DOI 10.1007/s00127-008-0395-0
   Rudolph KD, 2010, J ABNORM CHILD PSYCH, V38, P843, DOI 10.1007/s10802-010-9412-3
   Sapolsky RM, 2005, SCIENCE, V308, P648, DOI 10.1126/science.1106477
   Schreier A, 2009, ARCH GEN PSYCHIAT, V66, P527, DOI 10.1001/archgenpsychiatry.2009.23
   Shah T, 2009, INT J EPIDEMIOL, V38, P217, DOI 10.1093/ije/dyn217
   Shanahan L, 2013, PSYCHONEUROENDOCRINO, V38, P2209, DOI 10.1016/j.psyneuen.2013.04.010
   Sourander A, 2005, J AM ACAD CHILD PSY, V44, P756, DOI 10.1097/01.chi.0000164878.79986.2f
   Steptoe A, 2007, BRAIN BEHAV IMMUN, V21, P901, DOI 10.1016/j.bbi.2007.03.011
   Stewart JC, 2009, BRAIN BEHAV IMMUN, V23, P936, DOI 10.1016/j.bbi.2009.04.011
   Tamakoshi K, 2003, INT J OBESITY, V27, P443, DOI 10.1038/sj.ijo.0802260
   Williams SR, 2009, J GERONTOL B-PSYCHOL, V64, pI131, DOI 10.1093/geronb/gbn022
   Winsper C, 2012, J AM ACAD CHILD PSY, V51, P271, DOI 10.1016/j.jaac.2012.01.001
   Wolke D, 2001, ARCH DIS CHILD, V85, P197, DOI 10.1136/adc.85.3.197
   Wolke D, 2013, PSYCHOL SCI, V24, P1958, DOI 10.1177/0956797613481608
   Woodward M, 2003, BRIT J HAEMATOL, V122, P135, DOI 10.1046/j.1365-2141.2003.04387.x
   Worthman CM, 1997, AM J PHYS ANTHROPOL, V104, P1
NR 60
TC 199
Z9 224
U1 1
U2 81
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAY 27
PY 2014
VL 111
IS 21
BP 7570
EP 7575
DI 10.1073/pnas.1323641111
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA AH8TO
UT WOS:000336411300028
PM 24821813
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Tepebasi, MY
   Savran, M
   Cosan, S
   Tastan, SA
   Aydin, B
AF Tepebasi, Muhammet Yusuf
   Savran, Mehtap
   Cosan, Samet
   Tastan, Serife Agirca
   Aydin, Buenyamin
TI The protective role of selenium against high-fructose corn syrup-induced
   kidney damage: a histopathological and molecular analysis
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Apoptosis; Endoplasmic reticulum stress; High-fructose diet; Kidney;
   Rats; Selenium
ID ENDOPLASMIC-RETICULUM STRESS; INDUCED OXIDATIVE STRESS; INJURY;
   MECHANISMS; APOPTOSIS; EXTRACT; DISEASE
AB With the growth of the food industry, fructose, the intake of which increases with food, causes obesity and metabolic syndrome. Kidney damage may develop from metabolic syndrome. Selenium (Se) participates in the structure of antioxidant enzymes and has a medicinal effect. In this work, the protective impact of Se on kidney damage produced by high-fructose corn syrup (HFCS) via endoplasmic reticulum (ER) stress was examined. The study comprised four groups, each consisting of ten experimental animals: control, HFCS (20%-HFCS), HFCS (20%-HFCS), + Se (0.3 mg/kg/day/po), and Se (0.3 mg/kg/day/po) alone. The duration of the experiment was 6 weeks. Kidney tissues were stained with hematoxylin and eosin for histological examination. Immunohistochemical analysis was conducted to assess TNF-alpha and caspase-3 levels. The spectrophotometric evaluation was performed to measure TOS (total oxidant status), TAS (total antioxidant status), and OSI (oxidative stress index) levels. The PERK, ATF4, CHOP, BCL-2, and caspase-9 gene expression levels were assessed by the RT-qPCR method. After Se treatment, histopathological abnormalities and TNF-alpha and caspase-3 levels in the HFCS+Se group decreased (p < 0.001). While TOS and OSI levels increased dramatically in the HFCS group, TAS values decreased significantly but improved after Se application (p < 0.001). The expression levels of the genes PERK, ATF4, CHOP, and caspase-9 were significantly lower in the HFCS group when compared to the HFCS+Se group (p < 0.05). Our findings suggest that Se may protect against ER stress, oxidative stress, apoptosis, and kidney damage caused by high-dose fructose consumption.
C1 [Tepebasi, Muhammet Yusuf] Univ Suleyman Demirel, Dept Med Genet, TR-32300 Isparta, Turkiye.
   [Savran, Mehtap; Cosan, Samet] Suleyman Demirel Univ, Dept Med Pharmacol, Isparta, Turkiye.
   [Tastan, Serife Agirca] Univ Mehmet Akif Ersoy, Dept Patol, Burdur, Turkiye.
   [Aydin, Buenyamin] Kutahya Hlth Sci Univ, Dept Internal Med, Kutahya, Turkiye.
C3 Suleyman Demirel University; Suleyman Demirel University; Mehmet Akif
   Ersoy University; Kutahya Health Sciences University
RP Tepebasi, MY (corresponding author), Univ Suleyman Demirel, Dept Med Genet, TR-32300 Isparta, Turkiye.
EM muhammettepebasi@sdu.edu.tr
RI Tepebasi, Muhammet Yusuf/IZE-6149-2023
OI Tepebasi, Muhammet Yusuf/0000-0002-1087-4874
FU Sleyman Demirel niversitesi
FX No Statement Available
CR Abd Al Haleem EN, 2019, CHEM-BIOL INTERACT, V302, P108, DOI 10.1016/j.cbi.2019.01.022
   ABDEL-KAWI S.H., 2016, Beni-Suef University Journal of Basic and Applied Sciences, V5, P52, DOI DOI 10.1016/j.bjbas.2015.12.002
   Ahangarpour A, 2012, IRAN J MED SCI, V37, P181
   Al-Brakati A, 2021, INT J NANOMED, V16, P4335, DOI 10.2147/IJN.S306186
   Altindag O, 2008, RHEUMATOL INT, V28, P317, DOI 10.1007/s00296-007-0452-0
   Aoyama M, 2012, BIOCHEM BIOPH RES CO, V419, P244, DOI 10.1016/j.bbrc.2012.02.001
   Bratoeva KZ, 2017, J MIND MED SCI, V4, P163, DOI 10.22543/7674.42.P163171
   Cave M, 2007, J NUTR BIOCHEM, V18, P184, DOI 10.1016/j.jnutbio.2006.12.006
   Ekici Ö, 2022, J FOOD BIOCHEM, V46, DOI 10.1111/jfbc.13732
   Erel O, 2005, CLIN BIOCHEM, V38, P1103, DOI 10.1016/j.clinbiochem.2005.08.008
   Herst PM, 2017, FRONT ENDOCRINOL, V8, DOI 10.3389/fendo.2017.00296
   Huang H, 2019, THERIOGENOLOGY, V131, P146, DOI 10.1016/j.theriogenology.2019.03.015
   Ilhan I, 2024, BIOL TRACE ELEM RES, V202, P5166, DOI 10.1007/s12011-024-04081-z
   Ilhan I, 2023, MOL BIOL REP, V50, P1627, DOI 10.1007/s11033-022-08192-5
   Inagi R, 2014, NAT REV NEPHROL, V10, P369, DOI 10.1038/nrneph.2014.67
   Jin JK, 2017, CIRC RES, V120, P862, DOI 10.1161/CIRCRESAHA.116.310266
   Kizhner T, 2002, METABOLISM, V51, P1538, DOI 10.1053/meta.2002.36306
   Korkmaz A., 2008, Turk SIlahli KuvvetlerI,  Koruyucu HekImlIk BultenI, V7, P343
   Kurella M, 2005, J AM SOC NEPHROL, V16, P2134, DOI 10.1681/ASN.2005010106
   Lai HH, 2021, BIOL TRACE ELEM RES, V199, P185, DOI 10.1007/s12011-020-02112-z
   Lenaz G, 2001, IUBMB LIFE, V52, P159, DOI 10.1080/15216540152845957
   Letavayová L, 2008, MUTAT RES-FUND MOL M, V638, P1, DOI 10.1016/j.mrfmmm.2007.08.009
   Liu LL, 2015, BIOL TRACE ELEM RES, V167, P308, DOI 10.1007/s12011-015-0314-7
   Liu L, 2015, MOL MED REP, V12, P7933, DOI 10.3892/mmr.2015.4426
   Liu YM, 2021, BIOL TRACE ELEM RES, V199, P1833, DOI 10.1007/s12011-020-02279-5
   Reyes-Fermín LM, 2020, FOOD CHEM TOXICOL, V138, DOI 10.1016/j.fct.2020.111229
   Orek Y.S, 2020, Van Medical Journal, V27, P371, DOI [10.5505/vtd.2020.19981, DOI 10.5505/VTD.2020.19981]
   Oudot C, 2013, KIDNEY INT, V83, P674, DOI 10.1038/ki.2012.478
   Punitha ISR, 2005, EVID-BASED COMPL ALT, V2, P375, DOI 10.1093/ecam/neh099
   Reddy SS, 2009, FOOD CHEM TOXICOL, V47, P2224, DOI 10.1016/j.fct.2009.06.008
   Savran M, 2019, HUM EXP TOXICOL, V38, P1212, DOI 10.1177/0960327119860188
   Seylam A., 2021, ADNAN MENDERES UNIVE, V5, P422, DOI [10.46237/amusbfd.723499, DOI 10.46237/AMUSBFD.723499]
   Small DM, 2012, NEPHROLOGY, V17, P311, DOI 10.1111/j.1440-1797.2012.01572.x
   Smeraglio AC, 2013, NUTR RES, V33, P435, DOI 10.1016/j.nutres.2013.03.007
   Suganya N, 2014, CELL PROLIFERAT, V47, P231, DOI 10.1111/cpr.12102
   Topsakal S, 2019, BIOTECH HISTOCHEM, V94, P271, DOI 10.1080/10520295.2018.1552019
   Unsal V, 2021, NUTR FOOD SCI, V51, P345, DOI 10.1108/NFS-05-2020-0162
   Wan N, 2018, BIOL TRACE ELEM RES, V184, P463, DOI 10.1007/s12011-017-1193-x
   Wang MG, 2019, BBA-MOL CELL RES, V1866, P713, DOI 10.1016/j.bbamcr.2018.12.002
   Yao LL, 2015, BIOMETALS, V28, P255, DOI 10.1007/s10534-014-9819-3
   Yesilot Sukriye, 2022, Veterinary Journal of Mehmet Akif Ersoy University, V7, P26, DOI 10.24880/maeuvfd.981913
   Zhang Y, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/6059058
NR 42
TC 1
Z9 1
U1 7
U2 10
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD OCT
PY 2024
VL 397
IS 10
BP 7829
EP 7837
DI 10.1007/s00210-024-03149-w
EA MAY 2024
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA I2O0O
UT WOS:001220849400001
PM 38734838
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Wojciak, PA
   Pawluszewicz, P
   Diemieszczyk, I
   Komorowska-Wojtunik, E
   Czerniawski, M
   Kretowski, A
   Blachnio-Zabielska, A
   Dadan, J
   Ladny, J
   Hady, HR
AF Wojciak, Pawel A.
   Pawluszewicz, Patrycja
   Diemieszczyk, Inna
   Komorowska-Wojtunik, Ewa
   Czerniawski, Mikolaj
   Kretowski, Adam
   Blachnio-Zabielska, Agnieszka
   Dadan, Jacek
   Ladny, Jerzy
   Hady, Hady Razak
TI Laparoscopic sleeve gastrectomy: a study of efficiency in treatment of
   metabolic syndrome components, comorbidities and influence on certain
   biochemical markers
SO VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES
LA English
DT Article
DE metabolic syndrome; obesity; morbid obesity; bariatric surgery;
   laparoscopic sleeve gastrectomy
ID Y GASTRIC BYPASS; BARIATRIC SURGERY; OBESE-PATIENTS; LIPID PROFILE;
   SINGLE-CENTER; MORTALITY; IMPACT; EPIDEMIOLOGY; PARAMETERS; OUTCOMES
AB Introduction: The worldwide outbreak of morbid obesity forced contemporary medicine to adopt a multidisciplinary approach, which led to the description of metabolic syndrome (MS): a disease with self-aggravating components and one of the most important causes of morbidity and mortality. The need for therapeutic methods provoked development of metabolic surgery, which nowadays give possibilities for safe and effective treatment of all MS aspects simultaneously and improves many obesity-related comorbidities.
   Aim: To assess the laparoscopic sleeve gastrectomy (LSG) procedure's efficiency in resolving MS components, treating comorbidities and to analyze the influence on certain biochemical markers in 1-year follow-up.
   Material and methods: The retrospective cohort study of 211 patients after an LSG operation relied on statistical analysis of clinical data collected prospectively in follow-up visits. All applicable guidelines and bioethical recommendations were respected in this study.
   Results: Assessment of bariatric efficiency proved the LSG operation to be effective in inducing significant weight loss and treating obesity. Analysis on the influence on MS components, such as non-insulin dependent diabetes (NIDDM), arterial hypertension (AH) and dyslipidemia, showed substantial improvement in all observed cases of these diseases. In the present study, follow-up also proved a partial remission inducing effect of this bariatric operation in many comorbidities, especially in chronic obstructive pulmonary disease, obstructive sleep apnea, peptic ulcer disease and depression. A desirable reduction in creatinine, C-reactive protein, uric acid, alanine aminotransferase, asparagine aminotransferase, g-glutamyltransferase serum levels has also been observed during the follow-up.
   Conclusions: The LSG is an effective method of treatment in all areas of metabolic syndrome, provides a significant positive clinical outcome in obesity-related comorbidities and induces desirable changes in inflammatory, kidney and liver related biomarkers.
C1 [Wojciak, Pawel A.; Pawluszewicz, Patrycja; Diemieszczyk, Inna; Czerniawski, Mikolaj; Dadan, Jacek; Ladny, Jerzy; Hady, Hady Razak] Univ Clin Hosp Bialystok, Dept Gen & Endocrine Surg 1, 22-10 Bialostoczek St, PL-15869 Bialystok, Poland.
   [Komorowska-Wojtunik, Ewa] Minist Interior Hosp Bialystok, Intens Care Unit, Bialystok, Poland.
   [Kretowski, Adam] Univ Clin Hosp Bialystok, Dept Endocrinol Diabetol & Internal Dis, Bialystok, Poland.
   [Blachnio-Zabielska, Agnieszka] Med Univ Bialystok, Dept Hyg Epidemiol & Metab Disorders, Bialystok, Poland.
C3 Medical University of Bialystok
RP Wojciak, PA (corresponding author), Univ Clin Hosp Bialystok, Dept Gen & Endocrine Surg 1, 22-10 Bialostoczek St, PL-15869 Bialystok, Poland.
EM maphius@o2.pl
RI Blachnio-Zabielsk, Agnieszka/A-4879-2018; Ladny, Jerzy/S-4769-2018;
   Hady, Hady/T-7613-2018; Diemieszczyk, Inna/X-6657-2018; Kretowski,
   Adam/U-6299-2018
OI Kretowski, Adam/0000-0002-4522-4978; Dadan, Jacek/0000-0002-0691-9785
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Aminian A, 2016, ANN SURG, V264, P674, DOI 10.1097/SLA.0000000000001857
   Batterham RL, 2016, DIABETES CARE, V39, P893, DOI 10.2337/dc16-0145
   Boniecka I, 2017, VIDEOSURGERY MINIINV, V12, P60, DOI 10.5114/wiitm.2016.65078
   Buchwald H, 2004, JAMA-J AM MED ASSOC, V292, P1724, DOI 10.1001/jama.292.14.1724
   Budzynski A., 2016, Med. Prakt.Chir, V6, P13
   Buzga M, 2013, VIDEOSURGERY MINIINV, V8, P22, DOI 10.5114/wiitm.2011.31631
   Chang AR, 2017, KIDNEY INT REP, V2, P261, DOI 10.1016/j.ekir.2017.01.010
   Clinical Issues Committee of American Society for Metabolic and Bariatric Surgery, 2007, Surg Obes Relat Dis, V3, P573
   Cordero P, 2017, J ROY COLL PHYS EDIN, V47, P364, DOI 10.4997/JRCPE.2017.414
   Dardzinska JA, 2018, VIDEOSURGERY MINIINV, V13, P366, DOI 10.5114/wiitm.2018.75868
   El Chaar M, 2015, OBES SURG, V25, P254, DOI 10.1007/s11695-014-1388-6
   Frask A, 2017, VIDEOSURGERY MINIINV, V12, P160, DOI 10.5114/wiitm.2017.67678
   Garg H, 2017, WORLD J GASTRO ENDOS, V9, P162, DOI 10.4253/wjge.v9.i4.162
   Golomb I, 2015, JAMA SURG, V150, P1051, DOI 10.1001/jamasurg.2015.2202
   Hady HR, 2012, ADV MED SCI-POLAND, V57, P58, DOI 10.2478/v10039-012-0008-8
   Hady RH, 2010, ADV CLIN EXP MED, V19, P369
   Hafida S, 2016, CURR OPIN ENDOCRINOL, V23, P373, DOI 10.1097/MED.0000000000000277
   Heffron SP, 2016, AM J MED, V129, P952, DOI 10.1016/j.amjmed.2016.02.004
   Hoyuela C, 2017, WORLD J GASTRO SURG, V9, P109, DOI 10.4240/wjgs.v9.i4.109
   Hruby A, 2015, PHARMACOECONOMICS, V33, P673, DOI 10.1007/s40273-014-0243-x
   Hu G, 2004, ARCH INTERN MED, V164, P1066, DOI 10.1001/archinte.164.10.1066
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jastrzebska-Mierzynska M, 2015, VIDEOSURGERY MINIINV, V10, P115, DOI 10.5114/wiitm.2014.47764
   Kostecka M, 2017, VIDEOSURGERY MINIINV, V12, P207, DOI 10.5114/wiitm.2017.70193
   Kowalewski PK, 2018, OBES SURG, V28, P130, DOI 10.1007/s11695-017-2795-2
   Kral JG, 2007, NAT CLIN PRACT ENDOC, V3, P574, DOI 10.1038/ncpendmet0563
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Linton E.F., 2019, Endotext
   Major P, 2018, ACTA CHIR BELG, V118, P307, DOI 10.1080/00015458.2018.1433797
   Major P, 2018, INT J SURG, V56, P210, DOI 10.1016/j.ijsu.2018.06.022
   Major P, 2018, OBES SURG, V28, P1031, DOI 10.1007/s11695-017-2964-3
   Major Piotr, 2017, Pol Przegl Chir, V89, P1, DOI 10.5604/01.3001.0009.6003
   Mathieu P, 2006, VASC HEALTH RISK MAN, V2, P285, DOI 10.2147/vhrm.2006.2.3.285
   Meldrum DR, 2017, FERTIL STERIL, V107, DOI 10.1016/j.fertnstert.2017.02.104
   Milone M, 2015, INT J SURG, V14, P28, DOI 10.1016/j.ijsu.2014.12.025
   Morshed G, 2015, VIDEOSURGERY MINIINV, V10, P521, DOI 10.5114/wiitm.2015.56480
   Motheral B, 2003, VALUE HEALTH, V6, P90, DOI 10.1046/j.1524-4733.2003.00242.x
   Noria SF, 2013, CAN J SURG, V56, P47, DOI 10.1503/cjs.036111
   Schiavon CA, 2018, CIRCULATION, V137, P1132, DOI 10.1161/CIRCULATIONAHA.117.032130
   Shi XZ, 2010, OBES SURG, V20, P1171, DOI 10.1007/s11695-010-0145-8
   Stefura T, 2019, VIDEOSURGERY MINIINV, V14, P526, DOI 10.5114/wiitm.2019.81370
   Thang S, 2016, JRSM CARDIOVASC DIS, V5
   Toh B, 2018, DIABETES OBES METAB, V20, P1762, DOI 10.1111/dom.13263
   Vidal J, 2008, OBES SURG, V18, P1077, DOI 10.1007/s11695-008-9547-2
   von Elm E, 2014, INT J SURG, V12, P1495, DOI 10.1016/j.ijsu.2014.07.013
   World Health Organization, 2018, FACT SHEETS TOP 10 C
   Wroblewski E, 2016, CYTOKINE, V77, P56, DOI 10.1016/j.cyto.2015.10.013
   Zalewska A, 2013, ADV CLIN EXP MED, V22, P659
   Zhang N, 2013, SURG ENDOSC, V27, P1273, DOI 10.1007/s00464-012-2595-7
NR 50
TC 18
Z9 19
U1 0
U2 4
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1895-4588
EI 2299-0054
J9 VIDEOSURGERY MINIINV
JI Videosurgery Miniinvasive Tec.
PY 2020
VL 15
IS 1
BP 136
EP 147
DI 10.5114/wiitm.2019.84718
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KI1RL
UT WOS:000511125300019
PM 32117497
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Frisard, M
   Ravussin, E
AF Frisard, M
   Ravussin, E
TI Energy metabolism and oxidative stress - Impact on the metabolic
   syndrome and the aging process
SO ENDOCRINE
LA English
DT Article
DE oxidative stress; aging; obesity; type 2 diabetes; energy expenditure
ID RESPIRATORY-CHAIN FUNCTION; HUMAN SKELETAL-MUSCLE; CALORIC RESTRICTION;
   MITOCHONDRIAL-DNA; HYDROGEN-PEROXIDE; DIETARY RESTRICTION;
   LIPID-PEROXIDATION; PROTEIN OXIDATION; RISK FACTOR; COMPLEX-I
AB Aging can be defined as a progressive decline in the ability of the organism to resist stress, damage, and disease. Although there are currently over 300 theories to explain the aging phenomenon, it is still not well understood why organisms age and why the aging process can vary so much in speed and quality from individual to individual. The oxidative stress hypothesis is one of the prevailing theories of aging. This theory states that free radicals produced during cellular respiration damage lipids, proteins, and DNA thereby accelerating the aging process and increasing disease risk. Under normal conditions, the electron transport chain is the primary producer of the superoxide anion, which is precursor to other highly reactive species such as hydrogen peroxide and the hydroxyl radical. Oxidative stress accumulates when prooxidants overwhelm the antioxidant defense mechanisms. This is dependent on a number of factors including free radical production, susceptibility of tissue to stress, and strength of the defense and repair system. Oxidative stress has been implicated in a number of chronic disease states usually grouped under the umbrella of the metabolic syndrome and is thought to contribute to the aging process. It has been hypothesized that the production of free radicals is dependent on resting metabolic rate and this may have an impact on the aging process. However, other factors, such as mitochondrial function, may be important in the production of free radicals and the subsequent effect on aging and disease states.
C1 Louisiana State Univ, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center
RP Louisiana State Univ, Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM ravusse@pbrc.edu
RI Ravussin, Eric/N-1985-2017
OI Ravussin, Eric/0000-0003-2129-547X
CR AMES BN, 1993, P NATL ACAD SCI USA, V90, P7915, DOI 10.1073/pnas.90.17.7915
   ARAUJO FB, 1995, ATHEROSCLEROSIS, V117, P61, DOI 10.1016/0021-9150(94)05558-Z
   Arnaiz SL, 1995, BBA-MOL BASIS DIS, V1272, P175
   Austad SN, 1998, AGING-CLIN EXP RES, V10, P146
   BANDY B, 1990, FREE RADICAL BIO MED, V8, P523, DOI 10.1016/0891-5849(90)90152-9
   Barja G, 2004, TRENDS NEUROSCI, V27, P595, DOI 10.1016/j.tins.2004.07.005
   Batandier C, 2002, J CELL MOL MED, V6, P175, DOI 10.1111/j.1582-4934.2002.tb00185.x
   Beckman KB, 1998, PHYSIOL REV, V78, P547, DOI 10.1152/physrev.1998.78.2.547
   Beckman KB, 1998, ANN NY ACAD SCI, V854, P118, DOI 10.1111/j.1749-6632.1998.tb09897.x
   BIELSKI BHJ, 1983, J BIOL CHEM, V258, P4759
   Block G, 2002, AM J EPIDEMIOL, V156, P274, DOI 10.1093/aje/kwf029
   BOVERIS A, 1972, BIOCHEM J, V128, P617, DOI 10.1042/bj1280617
   CADENAS E, 1977, ARCH BIOCHEM BIOPHYS, V180, P248, DOI 10.1016/0003-9861(77)90035-2
   Carrozzo R, 2001, NEUROLOGY, V56, P687, DOI 10.1212/WNL.56.5.687
   Ceriello A, 2000, DIABETES, V49, P2170, DOI 10.2337/diabetes.49.12.2170
   CHANCE B, 1979, PHYSIOL REV, V59, P527, DOI 10.1152/physrev.1979.59.3.527
   Conley KE, 2000, J PHYSIOL-LONDON, V526, P203, DOI 10.1111/j.1469-7793.2000.t01-1-00203.x
   COOPER JM, 1992, J NEUROL SCI, V113, P91, DOI 10.1016/0022-510X(92)90270-U
   CUTLER RG, 1985, P NATL ACAD SCI USA, V82, P4798, DOI 10.1073/pnas.82.14.4798
   Desai VG, 1996, ARCH BIOCHEM BIOPHYS, V333, P145, DOI 10.1006/abbi.1996.0375
   Devaraj S, 2005, J CLIN ENDOCR METAB, V90, P4549, DOI 10.1210/jc.2005-0069
   Drew B, 2003, AM J PHYSIOL-REG I, V284, pR474, DOI 10.1152/ajpregu.00455.2002
   Finch CE., 1990, Longevity, Senescence, and the Genome
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   GARDNER HW, 1989, FREE RADICAL BIO MED, V7, P65, DOI 10.1016/0891-5849(89)90102-0
   Gredilla R, 2001, FASEB J, V15, P1589, DOI 10.1096/fj.00-0764fje
   Halliwell B, 1996, ANNU REV NUTR, V16, P33, DOI 10.1146/annurev.nu.16.070196.000341
   Halliwell B, 1998, OXYGEN RADICALS AND THE DISEASE PROCESS, P1
   Hamilton ML, 2001, NUCLEIC ACIDS RES, V29, P2117, DOI 10.1093/nar/29.10.2117
   Hamilton ML, 2001, P NATL ACAD SCI USA, V98, P10469, DOI 10.1073/pnas.171202698
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   HARMAN D, 1956, J GERONTOL, V11, P298, DOI 10.1093/geronj/11.3.298
   Herrero A, 1997, J BIOENERG BIOMEMBR, V29, P241, DOI 10.1023/A:1022458010266
   Heymsfield SB, 2002, AM J PHYSIOL-ENDOC M, V282, pE132, DOI 10.1152/ajpendo.2002.282.1.E132
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   KELLEY DE, 1994, J CLIN INVEST, V94, P2349, DOI 10.1172/JCI117600
   Kelley DE, 2002, DIABETES, V51, P2944, DOI 10.2337/diabetes.51.10.2944
   KU HH, 1993, FREE RADICAL BIO MED, V15, P621, DOI 10.1016/0891-5849(93)90165-Q
   Lee HC, 2005, INT J BIOCHEM CELL B, V37, P822, DOI 10.1016/j.biocel.2004.09.010
   Levine JA, 1999, SCIENCE, V283, P212, DOI 10.1126/science.283.5399.212
   MECOCCI P, 1994, ANN NEUROL, V36, P747, DOI 10.1002/ana.410360510
   Michikawa Y, 1999, SCIENCE, V286, P774, DOI 10.1126/science.286.5440.774
   Milton NGN, 2004, DRUG AGING, V21, P81, DOI 10.2165/00002512-200421020-00002
   Nishioka N, 2004, AM J GERIAT PSYCHIAT, V12, P167, DOI 10.1176/appi.ajgp.12.2.167
   ORR WC, 1994, SCIENCE, V263, P1128, DOI 10.1126/science.8108730
   Pearl R., 1928, RATE LIVING
   Petersen KF, 2003, SCIENCE, V300, P1140, DOI 10.1126/science.1082889
   Prentice AM, 1996, EUR J CLIN NUTR, V50, P93
   Promislow DEL, 2002, AGING CELL, V1, P66, DOI 10.1046/j.1474-9728.2002.00009.x
   RAMOS CL, 1992, J BIOL CHEM, V267, P8307
   Ravissun E., 1993, OBESITY THEORY THERA, P97
   Ravussin E, 1999, INT J OBESITY, V23, P37, DOI 10.1038/sj.ijo.0800793
   RAVUSSIN E, 1986, J CLIN INVEST, V78, P1568, DOI 10.1172/JCI112749
   RAVUSSIN E, 1988, NEW ENGL J MED, V318, P467, DOI 10.1056/NEJM198802253180802
   RAVUSSIN E, 1993, OBESITY THEORY THERA
   Redón J, 2003, HYPERTENSION, V41, P1096, DOI 10.1161/01.HYP.0000068370.21009.38
   Reilly MP, 1998, CIRCULATION, V98, P2822, DOI 10.1161/01.CIR.98.25.2822
   Roberts LJ, 2001, BIOCHEM BIOPH RES CO, V287, P254, DOI 10.1006/bbrc.2001.5583
   Russell AP, 2003, FEBS LETT, V551, P104, DOI 10.1016/S0014-5793(03)00875-5
   SACHER GA, 1979, FED PROC, V38, P184
   Schrauwen P, 2004, DIABETES, V53, P1412, DOI 10.2337/diabetes.53.6.1412
   Schulz JB, 2000, EUR J BIOCHEM, V267, P4904, DOI 10.1046/j.1432-1327.2000.01595.x
   Sigurdardottir V, 2002, J INTERN MED, V252, P440, DOI 10.1046/j.1365-2796.2002.01054.x
   Sohal RS, 1996, SCIENCE, V273, P59, DOI 10.1126/science.273.5271.59
   SOHAL RS, 1994, MECH AGEING DEV, V76, P215, DOI 10.1016/0047-6374(94)91595-4
   Sohal RS., 1985, Basic Life Sci, V35, P75, DOI DOI 10.1007/978-1-4899-2218-2_4
   Speakman JR, 2004, AGING CELL, V3, P87, DOI 10.1111/j.1474-9728.2004.00097.x
   St-Pierre J, 2002, J BIOL CHEM, V277, P44784, DOI 10.1074/jbc.M207217200
   Stadtman ER, 2006, FREE RADICAL RES, V40, P1250, DOI 10.1080/10715760600918142
   Stojiljkovic MP, 2002, J HYPERTENS, V20, P1215, DOI 10.1097/00004872-200206000-00036
   STROBEL HW, 1971, J BIOL CHEM, V246, P7826
   TATARANNI PA, 1995, INT J OBESITY, V19, pS102
   TROUNCE I, 1989, LANCET, V1, P637, DOI 10.1016/S0140-6736(89)92143-0
   TURRENS JF, 1980, BIOCHEM J, V191, P421, DOI 10.1042/bj1910421
   Urakawa H, 2003, J CLIN ENDOCR METAB, V88, P4673, DOI 10.1210/jc.2003-030202
   Vassalle C, 2004, J INTERN MED, V256, P308, DOI 10.1111/j.1365-2796.2004.01373.x
   WAGNER BA, 1994, BIOCHEMISTRY-US, V33, P4449, DOI 10.1021/bi00181a003
   WALLACE DC, 1992, SCIENCE, V256, P628, DOI 10.1126/science.1533953
   Yan LJ, 1997, P NATL ACAD SCI USA, V94, P11168, DOI 10.1073/pnas.94.21.11168
   Yan LJ, 1998, P NATL ACAD SCI USA, V95, P12896, DOI 10.1073/pnas.95.22.12896
   YOUNGMAN LD, 1992, P NATL ACAD SCI USA, V89, P9112, DOI 10.1073/pnas.89.19.9112
   Zainal TA, 2000, FASEB J, V14, P1825, DOI 10.1096/fj.99-0881com
NR 82
TC 142
Z9 168
U1 3
U2 17
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD FEB
PY 2006
VL 29
IS 1
BP 27
EP 32
DI 10.1385/ENDO:29:1:27
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 032JZ
UT WOS:000236772000005
PM 16622290
DA 2025-06-11
ER

PT J
AU Mansuroglu, S
   Kutlu, FY
AF Mansuroglu, Sercan
   Kutlu, F. Yasemin
TI The Transtheoretical Model based psychoeducation's effect on healthy
   lifestyle behaviours in schizophrenia: A randomized controlled trial
SO ARCHIVES OF PSYCHIATRIC NURSING
LA English
DT Article
DE Schizophrenia; Transtheoretical Model; Healthy lifestyle; Behavioural
   change; Mental health; Psychiatric nurse
ID QUALITY-OF-LIFE; SEVERE MENTAL-ILLNESS; PHYSICAL HEALTH; METABOLIC
   SYNDROME; BIPOLAR DISORDER; RISK-FACTORS; IMPROVEMENT PROFILE;
   CARDIOVASCULAR RISK; SMOKING-CESSATION; EXERCISE BEHAVIOR
AB Objective: The study was conducted with the pretest-posttest randomized controlled trial design to detect the psychoeducation's effect, based on the Transtheoretical Model, on the healthy lifestyle behaviours of individuals with schizophrenia.Methods: The data were collected from 82 participants, as 41 intervention and 41 control. The data were collected via personal information form, behavioural change stage diagnosis form and healthy lifestyle scale II. 6-week psychoeducation, consisting of 6 modules, based on the Transtheoretical Model, was applied to the interven-tion group. No interventions were applied to the control group. Pretests and posttests were applied to both groups.Results: When the healthy lifestyle scale II of intervention and control groups and final test results arranged according to ANCOVA analysis are compared, average final test results were meaningfully positive for the intervention group with taking control of the pretest and other covariants. When the pretest-posttest results in terms of behavioural change of the intervention group are evaluated; a meaningful difference among nutrition, physical exercises, spiritual self-improvement and stress management, which all are the stages of behavioural change, was detected.Conclusion: It was determined that psychoeducation on a healthy lifestyle, based on the Transtheoretical Model in an individual with schizophrenia affected physical exercises, spiritual self-improvement and interpersonal re-lationships sub-dimension in medium level, and had a drastic influence on health responsibility, nutrition, stress management sub-dimensions and all healthy lifestyle behaviours. Progress in behavioural change stages was detected.Clinical trials ID: NCT05259748.
C1 [Mansuroglu, Sercan] Istanbul Univ Cerrahpasa, Inst Grad Studies, Dept Mental Hlth & Psychiat Nursing, Istanbul, Turkey.
   [Kutlu, F. Yasemin] Istanbul Univ Cerrahpasa, Florence Nightingale Fac Nursing, Dept Mental Hlth & Psychiat Nursing, Istanbul, Turkey.
C3 Istanbul University - Cerrahpasa; Istanbul University - Cerrahpasa
RP Mansuroglu, S (corresponding author), Istanbul Univ Cerrahpasa, Inst Grad Studies, Dept Mental Hlth & Psychiat Nursing, Istanbul, Turkey.
EM sercanmansuroglu@gmail.com; kutluy@iuc.edu.tr
RI Mansuroğlu, Sercan/AGD-4682-2022; Kutlu, Fatma Yasemin/Q-6107-2017
OI Kutlu, Fatma Yasemin/0000-0003-0596-4258; Mansuroglu,
   Sercan/0000-0001-7562-0843
CR Acil AA, 2008, J PSYCHIATR MENT HLT, V15, P808, DOI 10.1111/j.1365-2850.2008.01317.x
   Silva BAE, 2015, REV BRAS PSIQUIATR, V37, P271, DOI 10.1590/1516-4446-2014-1595
   [Anonymous], 2016, PSIKIYATRIDE GUNCEL
   [Anonymous], 2016, Equally Well Consensus Statement: Improving the physical health and wellbeing of people living with mental illness in Australia
   Aveyard P, 2006, BRIT J HEALTH PSYCH, V11, P263, DOI 10.1348/135910705X52534
   Aveyard P, 2009, SOC SCI MED, V68, P397, DOI 10.1016/j.socscimed.2008.10.036
   Ay S., 2008, GAIT POSTURE, V28, pS118, DOI [10.1016/S0966-6362(08)70182-6, DOI 10.1016/S0966-6362(08)70182-6]
   Bahar Z., 2008, Cumhuriyet Universitesi Hemsirelik Yuksekokulu Dergisi, V12, P1, DOI DOI 10.15869/ITOBIAD.57244
   Baller JB, 2015, BMC PSYCHIATRY, V15, DOI 10.1186/s12888-015-0416-y
   Baysal Y. H., 2013, THESIS ERZURUM
   Bonfioli E, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-78
   Burghardt KJ, 2013, MOL DIAGN THER, V17, P21, DOI 10.1007/s40291-013-0017-8
   Buyukozturk S., 2011, Sosyal bilimler icin veri analizi el kitabi
   Cavusoglu F., 2018, THESIS IZMIR
   Ince SC, 2021, PERSPECT PSYCHIATR C, V57, P1751, DOI 10.1111/ppc.12745
   Chen SM, 2012, INT J NURS STUD, V49, P637, DOI 10.1016/j.ijnurstu.2011.11.011
   Choong E, 2012, J PSYCHIATR RES, V46, P540, DOI 10.1016/j.jpsychires.2012.01.014
   CIhangIroglu Z., 2011, Firat Tip Dergisi, V16, P78
   COHEN J, 1992, PSYCHOL BULL, V112, P155, DOI 10.1037/0033-2909.112.1.155
   Collins E, 2012, J PSYCHIATR MENT HLT, V19, P638, DOI 10.1111/j.1365-2850.2011.01831.x
   Correll CU, 2015, WORLD PSYCHIATRY, V14, P56, DOI 10.1002/wps.20187
   Costa R, 2018, PSYCHIAT RES, V267, P382, DOI 10.1016/j.psychres.2018.06.022
   Crump C, 2013, AM J PSYCHIAT, V170, P324, DOI 10.1176/appi.ajp.2012.12050599
   Daumit GL, 2013, NEW ENGL J MED, V368, P1594, DOI 10.1056/NEJMoa1214530
   Davis R, 2015, HEALTH PSYCHOL REV, V9, P323, DOI 10.1080/17437199.2014.941722
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P138
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   Dipasquale S, 2013, J PSYCHIATR RES, V47, P197, DOI 10.1016/j.jpsychires.2012.10.005
   Dodd KJ, 2011, DISABIL REHABIL, V33, P1222, DOI 10.3109/09638288.2010.526162
   Döngel BD, 2018, CUKUROVA MED J, V43, P892, DOI 10.17826/cumj.396313
   Erginer DK, 2018, PERSPECT PSYCHIATR C, V54, P371, DOI 10.1111/ppc.12261
   Erkal Aksoy Y., 2021, Genel Tp Dergisi, V31, P330, DOI [10.54005/geneltip.1036367, DOI 10.54005/GENELTIP.1036367]
   Erol S., 2007, ANADOLU HEMSIRELIK S, V10, P86
   Firth J, 2019, LANCET PSYCHIAT, V6, P675, DOI 10.1016/S2215-0366(19)30132-4
   Fusar-Poli P, 2009, PERSPECT PSYCHIATR C, V45, P87, DOI 10.1111/j.1744-6163.2009.00202.x
   Gandhi S, 2019, ASIAN J PSYCHIATR, V45, P95, DOI 10.1016/j.ajp.2019.09.008
   Göhner W, 2015, PATIENT EDUC COUNS, V98, P1385, DOI 10.1016/j.pec.2015.06.006
   Gomes E, 2014, MENT HEALTH PHYS ACT, V7, P155, DOI 10.1016/j.mhpa.2014.07.002
   Gong J, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0139442
   Gothefors D, 2010, NORD J PSYCHIAT, V64, P294, DOI 10.3109/08039488.2010.500397
   Guilbert JJ, 2006, EDUC HEALTH, V19, P385, DOI 10.1080/13576280600937911
   Gumus Ersoy M., 2019, THESIS MARMARA U TIP
   Gungormus Z., 2012, U J HLTH SCI, V1, P165
   Hardy S, 2010, INT J MENT HEALTH NU, V19, P350, DOI 10.1111/j.1447-0349.2010.00686.x
   Hashemzadeh M, 2019, IRAN J NURS MIDWIFE, V24, P83, DOI 10.4103/ijnmr.IJNMR_94_17
   Holt RIG, 2019, BRIT J PSYCHIAT, V214, P63, DOI 10.1192/bjp.2018.167
   Ipekçioglu D, 2019, MED J BAKIRKOY, V15, P103, DOI 10.4274/BTDMJB.galenos.2019.20190214042203
   Jakobsen AS, 2018, SCHIZOPHR RES, V199, P109, DOI 10.1016/j.schres.2018.03.016
   Kim Y, 2006, INT J BEHAV MED, V13, P295, DOI 10.1207/s15327558ijbm1304_4
   Kol E., 2015, SGD SOSYAL GUVENLIK, V5, P135
   lhan I., 2010, MALTEPE U HEMSIRELIK, V3, P35
   Li XY, 2020, BMC PUBLIC HEALTH, V20, DOI 10.1186/s12889-020-08568-x
   Loh Siew Yim, 2015, Glob J Health Sci, V8, P238, DOI 10.5539/gjhs.v8n1p238
   Lundström S, 2017, ISSUES MENT HEALTH N, V38, P717, DOI 10.1080/01612840.2017.1330909
   Malchow B, 2013, EUR ARCH PSY CLIN N, V263, P451, DOI 10.1007/s00406-013-0423-2
   Malhotra N, 2016, INDIAN J MED RES, V143, P434, DOI 10.4103/0971-5916.184284
   Masa-Font R, 2015, EUR PSYCHIAT, V30, P1028, DOI 10.1016/j.eurpsy.2015.09.006
   McKenna H.P., 2008, VITAL NOTES NURSES N
   Meepring S, 2018, INT J MENT HEALTH NU, V27, P126, DOI 10.1111/inm.12301
   Mohebbi B, 2021, J EDUC HEALTH PROMOT, V10, DOI 10.4103/jehp.jehp_1434_20
   Murphy JA, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00091
   Nigg CR, 2001, ANN BEHAV MED, V23, P11, DOI 10.1207/S15324796ABM2301_3
   Nordentoft M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055176
   Oflaz F., 2016, TOPLUM RUH SAGLIGI H, V6th
   Ohlsen R I, 2005, J Psychiatr Ment Health Nurs, V12, P614
   Ozer S., 2018, THESIS
   Ozyazicioglu N., 2011, ULUSLARARASI INSAN B, V2, P278
   Pallant J., 2017, SPSS KULLANMA K LAVU, V2
   Pan YJ, 2020, EPIDEMIOL PSYCH SCI, V29, DOI 10.1017/S2045796020000694
   Patel V, 2016, SCHIZOPHRENIA BULL, V42, P885, DOI 10.1093/schbul/sbv107
   Petzold MB, 2019, EUR ARCH PSY CLIN N, V269, P529, DOI 10.1007/s00406-018-0941-z
   Prapavessis H., 2004, Journal of Adolescent Health, V35, p346., DOI DOI 10.1016/J.JADOHEALTH.2003.11.096
   PROCHASKA JO, 1994, HEALTH EDUC QUART, V21, P471, DOI 10.1177/109019819402100410
   Prochaska JO, 1997, AM J HEALTH PROMOT, V12, P38, DOI 10.4278/0890-1171-12.1.38
   PROCHASKA JO, 1982, PSYCHOTHER-THEOR RES, V19, P276, DOI 10.1037/h0088437
   Rahimdel T, 2019, HEALTH EDUC RES, V34, P268, DOI 10.1093/her/cyz007
   Ratliff' JC, 2012, COMPR PSYCHIAT, V53, P1028, DOI 10.1016/j.comppsych.2012.02.003
   Sahin T, 2018, THESIS ANKARA
   Saxena S, 2017, WORLD PSYCHIATRY, V16, P1, DOI 10.1002/wps.20403
   Sharifirad GR, 2012, J RES MED SCI, V17, P1128
   Sharma M., 2015, WebmedCentral Behaviour, V6, pWMC004982, DOI DOI 10.1186/S12889-018-5388-7
   Shinitzky HE, 2001, PUBLIC HEALTH NURS, V18, P178, DOI 10.1046/j.1525-1446.2001.00178.x
   Simonelli-Muñoz AJ, 2012, INT J MENT HEALTH NU, V21, P220, DOI 10.1111/j.1447-0349.2012.00821.x
   Songur C, 2019, Balkan Sosyal Bilimler Dergisi, V8, P43
   Spencer L, 2006, HEALTH PROMOT PRACT, V7, P428, DOI 10.1177/1524839905278900
   Strassnig M, 2017, EARLY INTERV PSYCHIA, V11, P229, DOI 10.1111/eip.12225
   Stubbs B, 2015, ACTA PSYCHIAT SCAND, V132, P144, DOI 10.1111/acps.12439
   Stubbs B, 2016, INT J MENT HEALTH NU, V25, P484, DOI 10.1111/inm.12256
   Tanyeri B., 2019, THESIS ELAZIG
   Tosun S. A., 2015, THESIS KAYSERT
   Uur M., 2008, DAVRAN FIZYOLOJISI S, P51
   Van Citters AD, 2010, COMMUNITY MENT HLT J, V46, P540, DOI 10.1007/s10597-009-9272-x
   van Nes M, 2010, J AM ACAD NURSE PRAC, V22, P654, DOI 10.1111/j.1745-7599.2010.00561.x
   Vancampfort D, 2017, WORLD PSYCHIATRY, V16, P308, DOI 10.1002/wps.20458
   Vancampfort D, 2016, DISABIL REHABIL, V38, P2047, DOI [10.3109/09638288.2015.1114037, 10.1080/09638288.2016.1260645]
   Walker ER, 2015, JAMA PSYCHIAT, V72, P334, DOI 10.1001/jamapsychiatry.2014.2502
   Walker S.N., 1995, Health Promotion Model - Instruments to Measure Health Promoting Lifestyle : Health-Promoting Lifestyle Profile [HPLP II] (Adult Version)
   WALKER SN, 1987, NURS RES, V36, P76
   World Health Organization, 2019, PREM DEATH PEOPL SEV
   World Health Organization [WHO], 2018, Schizophrenia
   World Health Statistics, 2019, MON HLTH SDGS SUST D
   Yalçinkaya-Alkar Ö, 2007, ADDICT BEHAV, V32, P836, DOI 10.1016/j.addbeh.2006.06.023
   Yalcinoz Baysal H., 2013, THESIS ERZURUM
   Yasar H, 2021, TURK PSIKIYATR DERG, V32, P151, DOI 10.5080/u25752
   yekin D. G., 2009, ANADOLU PSIKIYATR DE, V10, P26
   Zhang JP, 2016, SCHIZOPHRENIA BULL, V42, P1418, DOI 10.1093/schbul/sbw058
NR 106
TC 5
Z9 5
U1 3
U2 37
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0883-9417
EI 1532-8228
J9 ARCH PSYCHIAT NURS
JI Arch. Psychiatr. Nurs.
PD DEC
PY 2022
VL 41
BP 51
EP 61
DI 10.1016/j.apnu.2022.07.018
EA JUL 2022
PG 11
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 3P0ZT
UT WOS:000837269700007
PM 36428075
DA 2025-06-11
ER

PT J
AU Mitchell, JC
   Paulson, J
   Cannarozzi, M
   Neer, SM
   Cassisi, JE
AF Mitchell, Jonathan C.
   Paulson, Joyce
   Cannarozzi, Maria
   Neer, Sandra M.
   Cassisi, Jeffrey E.
TI Maladaptive Cardiac Autonomic Control during a Stress Reactivity
   Assessment Among Primary Care Patients with Metabolic Syndrome
SO APPLIED PSYCHOPHYSIOLOGY AND BIOFEEDBACK
LA English
DT Article
DE Sympathovagal activity; Cardiac autonomic balance; Cardiac autonomic
   regulation; Impedance cardiography
ID IMPEDANCE CARDIOGRAPHY; SEX-DIFFERENCES; RESPONSES; DISEASE; SPACE
AB Metabolic syndrome (MetS) comprises a constellation of metabolic abnormalities that substantially increase risk for chronic illnesses. Autonomic dysregulation is closely linked to MetS, and while pathophysiological models often address chronic stress exposure, none have examined how such physiological contributions operate situationally, in a clinical setting. We used ambulatory impedance cardiography to examine indicators of cardiac autonomic control (CAC) in a sample of 50 adult primary care patients with and without MetS. Indices of independent sympathetic and parasympathetic cardiovascular control in primary care outpatients were measured during a brief stress reactivity assessment. We compared interdependent CAC features, including cardiac autonomic balance (i.e., sympathovagal reciprocity) and cardiac autonomic regulation (i.e., sympathovagal coactivation) and found significant differences among MetS participants as compared to healthy controls. In particular, cardiac autonomic regulation scores were higher among MetS patients when discussing medication concerns, and cardiac autonomic balance scores were lower among MetS patients when discussing daily stressors. These results suggest that patients meeting criteria for MetS demonstrate momentary variations in CAC depending on personally relevant health topics. The potential for future research is discussed with a focus on prospective data collection to enhance diagnostic procedures and treatment monitoring.
C1 [Mitchell, Jonathan C.; Neer, Sandra M.; Cassisi, Jeffrey E.] Univ Cent Florida, Dept Psychol, Coll Sci, 4111 Pictor Lane, Orlando, FL 32816 USA.
   [Paulson, Joyce; Cannarozzi, Maria] Univ Cent Florida, Coll Med, UCF Hlth, Orlando, FL 32816 USA.
C3 State University System of Florida; University of Central Florida; State
   University System of Florida; University of Central Florida
RP Mitchell, JC (corresponding author), Univ Cent Florida, Dept Psychol, Coll Sci, 4111 Pictor Lane, Orlando, FL 32816 USA.
EM Jonathan.Mitchell@ucf.edu
RI Mitchell, Jonathan/JJC-1266-2023; Cassisi, Jeffrey/S-2974-2018
OI Cassisi, Jeffrey/0000-0003-2288-5690
CR Berntson GG, 2008, PSYCHOPHYSIOLOGY, V45, P643, DOI 10.1111/j.1469-8986.2008.00652.x
   Berntson GG, 2007, HANDBOOK OF PSYCHOPHYSIOLOGY, 3RD EDITION, P182, DOI 10.1017/CBO9780511546396.008
   BERNTSON GG, 1993, PSYCHOL BULL, V114, P296, DOI 10.1037/0033-2909.114.2.296
   BERNTSON GG, 1994, PSYCHOPHYSIOLOGY, V31, P44, DOI 10.1111/j.1469-8986.1994.tb01024.x
   Blascovich J, 1996, ADV EXP SOC PSYCHOL, V28, P1, DOI 10.1016/S0065-2601(08)60235-X
   Blascovich J., 2008, HDB MOTIVATION SCI, P481
   Canale MP, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/865965
   Carthy ER, 2015, CLIN PHYSIOL FUNCT I, V35, P150, DOI 10.1111/cpf.12143
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Flaa A, 2008, METABOLISM, V57, P1422, DOI 10.1016/j.metabol.2008.05.012
   Grundy SM, 2006, CURR OPIN CARDIOL, V21, P1, DOI 10.1097/01.hco.0000200416.65370.a0
   Guerra S, 2011, AM J PHYSIOL-HEART C, V301, pH592, DOI 10.1152/ajpheart.01195.2010
   Guseman EH, 2016, J PEDIATR ENDOCR MET, V29, P63, DOI 10.1515/jpem-2015-0185
   Hjemdahl P, 2002, CIRCULATION, V106, P2634, DOI 10.1161/01.CIR.0000041502.43564.79
   Janczura M, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0133750
   KIRSCHBAUM C, 1993, NEUROPSYCHOBIOLOGY, V28, P76, DOI 10.1159/000119004
   Krzesinski P, 2013, MED SCI MONITOR, V19, DOI 10.12659/MSM.883870
   Lambert GW, 2010, PHARMACOL THERAPEUT, V126, P159, DOI 10.1016/j.pharmthera.2010.02.002
   Lee Yong-Ho, 2005, Curr Diab Rep, V5, P70
   Licht CMM, 2013, J CLIN ENDOCR METAB, V98, P2484, DOI 10.1210/jc.2012-3104
   Licht CMM, 2010, J CLIN ENDOCR METAB, V95, P2458, DOI 10.1210/jc.2009-2801
   Lozano DL, 2007, PSYCHOPHYSIOLOGY, V44, P113, DOI 10.1111/j.1469-8986.2006.00468.x
   Malliani Alberto, 2005, Eur J Intern Med, V16, P12, DOI 10.1016/j.ejim.2004.06.016
   Manganelli F, 2002, AM J CARDIOL, V89, P1405, DOI 10.1016/S0002-9149(02)02354-8
   Marcus Y, 2016, J CLIN HYPERTENS, V18, P19, DOI 10.1111/jch.12685
   Masuo K, 1997, AM J HYPERTENS, V10, P77, DOI 10.1016/S0895-7061(96)00303-2
   McGrady Angele, 2010, Cleve Clin J Med, V77 Suppl 3, pS68, DOI 10.3949/ccjm.77.s3.12
   Miller JG, 2015, DEV PSYCHOL, V51, P36, DOI 10.1037/a0038236
   Ordaz S, 2012, PSYCHONEUROENDOCRINO, V37, P1135, DOI 10.1016/j.psyneuen.2012.01.002
   Quintana DS, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00048
   SHERWOOD A, 1993, CARDIOVASCULAR REACTIVITY TO PSYCHOLOGICAL STRESS & DISEASE, P157, DOI 10.1037/10125-007
   SHERWOOD A, 1990, PSYCHOPHYSIOLOGY, V27, P1, DOI 10.1111/j.1469-8986.1990.tb02171.x
   SLOAN RP, 1995, PSYCHOPHYSIOLOGY, V32, P452, DOI 10.1111/j.1469-8986.1995.tb02096.x
   STONEY CM, 1987, PSYCHOPHYSIOLOGY, V24, P127, DOI 10.1111/j.1469-8986.1987.tb00264.x
   Tabachnick BG., 2013, USINGMULTIVARIATE ST
   Wahba IM, 2007, CLIN J AM SOC NEPHRO, V2, P550, DOI 10.2215/CJN.04071206
   Wakkee M, 2007, ATHEROSCLEROSIS, V190, P1, DOI 10.1016/j.atherosclerosis.2006.07.011
NR 37
TC 3
Z9 4
U1 0
U2 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1090-0586
EI 1573-3270
J9 APPL PSYCHOPHYS BIOF
JI Appl. Psychophysiol. Biofeedback
PD JUN
PY 2017
VL 42
IS 2
BP 97
EP 105
DI 10.1007/s10484-017-9355-3
PG 9
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA EW7RR
UT WOS:000402713000003
PM 28251420
DA 2025-06-11
ER

PT J
AU Azizi, M
   Yazdani, F
   Nikbakht, R
   Shahhosseini, Z
AF Azizi, Marzieh
   Yazdani, Fereshteh
   Nikbakht, Roya
   Shahhosseini, Zohreh
TI The Biopsychosocial Outcomes of Childlessness or Having One Child on
   Couple's Health: A Systematic Review
SO JOURNAL OF PEDIATRICS REVIEW
LA English
DT Review
DE Single child; Childlessness; Health outcome; Panel study
ID LIFE; PARENTHOOD; MEN; INFERTILITY; MORTALITY; QUALITY; SUPPORT
AB Background: The increase in childlessness or having one child is one of the significant changes in the demographic structure, especially in developed countries. Literature review shows that having no child or only one child affects the individual's health from various perspectives. Objectives: This study aimed to investigate the biopsychosocial outcomes of childlessness or having one child on couples' health. Methods: In this systematic review, the research question was about the biopsychosocial outcomes of childlessness or having a single child on couples' health. A systematic literature search was done in PubMed, Scopus, Web of Science, ScienceDirect, and the Iranian database, including SID. We employed the following keywords: "Single child," "childlessness," "health outcome," and "panel study." The quality assessment of the included studies was carried out using the Newcastle-Ottawa scale (NOS) for cohort studies. Results: Nine studies were included in this study. The results were analyzed based on the biopsychosocial perspective. From a biological perspective, women with no child or one child and those who had cesarean section showed poorer physical health scores than women with two children and vaginal delivery. Also, other studies showed the impact of childlessness on the higher probability of cardiovascular disease and mortality, metabolic syndrome, and diabetes in men. From a psychological perspective, the studies included in this field had controversial results. Most of the included studies showed that childless women or women with one child had lower scores in mental health compared to women with two children. In addition, women with a cesarean section also had poorer mental health compared to those with vaginal delivery. Also, childlessness in old adults can cause psychological effects such as less life satisfaction, feelings of more anxiety, and loneliness. From a social perspective, one study showed that childless men are different from fathers with children in terms of participation in society, income level, and life satisfaction. Conclusions: The results of this study indicate that childless couples may have various health problems in biological, psychological, and social aspects, which, in general, negatively affect their quality of life. The results of this study can be a good resource for policymakers and health specialists to design and implement cost-effective interventions to improve fertility indicators among the Iranian population.
C1 [Azizi, Marzieh; Shahhosseini, Zohreh] Mazandaran Univ Med Sci, Fac Nursing & Midwifery, Sexual & Reprod Hlth Res Ctr, Dept Midwifery, Sari, Iran.
   [Yazdani, Fereshteh] Mazandaran Univ Med Sci, Hlth Sci Res Ctr, Sari, Iran.
   [Nikbakht, Roya] Mazandaran Univ Med Sci, Fac Hlth, Dept Biostat & Epidemiol, Sari, Iran.
C3 Mazandaran University of Medical Sciences; Mazandaran University of
   Medical Sciences; Mazandaran University of Medical Sciences
RP Shahhosseini, Z (corresponding author), Mazandaran Univ Med Sci, Fac Nursing & Midwifery, Sexual & Reprod Hlth Res Ctr, Dept Midwifery, Sari, Iran.
EM zshahhosseini@yahoo.com
RI Shahhosseini, Zohreh/F-3445-2017
FU Mazandaran University of Medical Sciences, Sari, Iran
FX This study was financially supported by Mazandaran University of Medical
   Sciences, Sari, Iran.
CR Agerbo E, 2013, J EPIDEMIOL COMMUN H, V67, P374, DOI 10.1136/jech-2012-201387
   Bagi M, 2023, J Popul Assoc Iran, V18, P97, DOI 10.22034/jpai.2023.2004173.1292
   Beaujouan E, 2015, Vienna Institute of Demography Working Papers
   Behmanesh F, 2019, Iran J Epidemiol, V15, P279
   Bener A, 2009, INT UROL NEPHROL, V41, P777, DOI 10.1007/s11255-009-9565-6
   Bhaskar S, 2017, Recent Adv Psychol, V4, P42
   Bolton D, 2019, BIOPSYCHOSOCIAL MODEL OF HEALTH AND DISEASE: NEW PHILOSOPHICAL AND SCIENTIFC DEVELOPMENTS, P109, DOI 10.1007/978-3-030-11899-0_4
   Budig MJ, 2012, SOC POLIT, V19, P163, DOI 10.1093/sp/jxs006
   Bungum AB, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2017-020293
   Bures RM, 2009, J FAM ISSUES, V30, P670, DOI 10.1177/0192513X08331114
   Card AJ, 2023, HEALTH SYST, V12, P387, DOI 10.1080/20476965.2022.2029584
   Chen PC, 2022, WORLD J MENS HEALTH, V40, P490, DOI 10.5534/wjmh.210098
   Chou KL, 2004, INT J GERIATR PSYCH, V19, P449, DOI 10.1002/gps.1111
   Davis DL, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0273366
   Dykstra PA, 2006, RES AGING, V28, P749, DOI 10.1177/0164027506291745
   Einiö E, 2016, POP STUD-J DEMOG, V70, P217, DOI 10.1080/00324728.2016.1195506
   Elenkov A, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0237422
   Farland LV, 2023, J AM HEART ASSOC, V12, DOI 10.1161/JAHA.122.027755
   Fekri kia R, 2013, Soc Res, V28, P169
   Feng ZX, 2018, AGE AGEING, V47, P275, DOI 10.1093/ageing/afx137
   Foroutan Y, 2021, J Popul Assoc Iran, V16, P177, DOI [10.22034/jpai.2022.535805.1192, DOI 10.22034/JPAI.2022.535805.1192]
   Glazer CH, 2017, SEMIN REPROD MED, V35, P282, DOI 10.1055/s-0037-1603568
   Graham M, 2015, WOMEN HEALTH ISS, V25, P176, DOI 10.1016/j.whi.2014.12.002
   Grundy E, 2010, SOC SCI MED, V70, P1847, DOI 10.1016/j.socscimed.2010.02.004
   Hansen T, 2009, SOC INDIC RES, V94, P343, DOI 10.1007/s11205-008-9426-1
   Heravi M, 2020, Q J Islam Stud Soc Inj., V2, P163
   Huijts T, 2013, EUR SOCIOL REV, V29, P32, DOI 10.1093/esr/jcr037
   Jun-qing F, 2020, P 2020 4 INT SEM ED, DOI [10.2991/assehr.k.200826.253, DOI 10.2991/ASSEHR.K.200826.253]
   Kasturi SS, 2008, J ANDROL, V29, P251, DOI 10.2164/jandrol.107.003731
   Keizer R, 2010, EUR SOCIOL REV, V26, P1, DOI 10.1093/esr/jcn080
   Klaus D, 2016, ADV LIFE COURSE RES, V29, P95, DOI 10.1016/j.alcr.2015.12.004
   Knoester C, 2006, J FAM ISSUES, V27, P1532, DOI 10.1177/0192513X06290802
   Luchini C, 2017, WORLD J META-ANAL, V5, P80, DOI 10.13105/wjma.v5.i4.80
   Margulis AV, 2014, CLIN EPIDEMIOL, V6, P359, DOI 10.2147/CLEP.S66677
   Maximova K, 2009, SOC SCI MED, V68, P850, DOI 10.1016/j.socscimed.2008.11.012
   Miettinen A., 2010, Finnish Yearbook of Population Research, V45, P5, DOI DOI 10.23979/FYPR.45051
   Miettinen A., 2015, Increasing childlessness in Europe: Time trends and country differences
   Mohaddesi H, 2022, J Obstet Gynecol Cancer Res, V7, P341, DOI [10.30699/jogcr.7.4.341, DOI 10.30699/JOGCR.7.4.341]
   Nasrabad HBR, 2013, 27 INT POP C IUSSP 2
   Okpan SO, 2021, Niger J Soc Probl Soc Policy Rev, V1
   Page Matthew J, 2021, BMJ, V372, pn71, DOI [10.1016/j.ijsu.2021.105906, 10.1136/bmj.n71]
   Patel DN, 2023, A road without a map: An interpretative phenomenological analysis of intentional childlessness in Indian American women
   Quashie NT, 2021, J GERONTOL B-PSYCHOL, V76, P348, DOI 10.1093/geronb/gbz153
   Rowland DT, 2007, J FAM ISSUES, V28, P1311, DOI 10.1177/0192513X07303823
   Rybinska A, 2019, SOC FORCES, V97, P1571, DOI 10.1093/sf/soy098
   Salonia A, 2009, EUR UROL, V56, P1025, DOI 10.1016/j.eururo.2009.03.001
   Sappleton N, 2018, Emerald studies in reproduction, culture and society, DOI [10.1108/9781787543614, DOI 10.1108/9781787543614]
   Tocchioni V, 2018, DEMOGR RES, V38, P451, DOI 10.4054/DemRes.2018.38.19
   Ventimiglia E, 2015, FERTIL STERIL, V104, P48, DOI 10.1016/j.fertnstert.2015.04.020
   Vikström J, 2011, BMC GERIATR, V11, DOI 10.1186/1471-2318-11-78
   Wenger GC, 2007, J FAM ISSUES, V28, P1419, DOI 10.1177/0192513X07303895
   Yahyanejad A, 2022, J NURS MIDWIFERY SCI, V9, P73, DOI 10.4103/JNMS.JNMS_81_20
   Zhang WG, 2007, J CROSS-CULT GERONTO, V22, P185, DOI 10.1007/s10823-007-9037-3
   Zhang ZM, 2001, J GERONTOL B-PSYCHOL, V56, pS311, DOI 10.1093/geronb/56.5.S311
NR 54
TC 0
Z9 0
U1 0
U2 0
PU MAZANDARAN UNIV MED SCI
PI SARI
PA BOU ALI SINA HOSP, PASDARAN BLVD, SARI, 48158-38477, IRAN
SN 2322-4398
EI 2322-4401
J9 J PEDIAT REV
JI J. Pediat. Rev.
PD JAN
PY 2025
VL 13
IS 1
BP 17
EP 28
DI 10.32598/jpr.13.1.902.3
PG 12
WC Pediatrics
WE Emerging Sources Citation Index (ESCI)
SC Pediatrics
GA 2UX8Q
UT WOS:001491912600003
OA gold
DA 2025-06-11
ER

PT J
AU Laaboub, N
   Dubath, C
   Ranjbar, S
   Sibailly, G
   Grosu, C
   Piras, M
   Délessert, D
   Richard-Lepouriel, H
   Ansermot, N
   Crettol, S
   Vandenberghe, F
   Grandjean, C
   Delacrétaz, A
   Gamma, F
   Plessen, KJ
   von Gunten, A
   Conus, P
   Eap, CB
AF Laaboub, Nermine
   Dubath, Celine
   Ranjbar, Setareh
   Sibailly, Guibet
   Grosu, Claire
   Piras, Marianna
   Delessert, Didier
   Richard-Lepouriel, Helene
   Ansermot, Nicolas
   Crettol, Severine
   Vandenberghe, Frederik
   Grandjean, Carole
   Delacretaz, Aurelie
   Gamma, Franziska
   Plessen, Kerstin Jessica
   von Gunten, Armin
   Conus, Philippe
   Eap, Chin B.
TI Insomnia disorders are associated with increased cardiometabolic
   disturbances and death risks from cardiovascular diseases in psychiatric
   patients treated with weight-gain-inducing psychotropic drugs: results
   from a Swiss cohort
SO BMC PSYCHIATRY
LA English
DT Article
DE Psychiatry; Insomnia disorders; Metabolic syndrome; Metabolic worsening;
   Cardiovascular diseases
ID SHORT-SLEEP DURATION; METABOLIC SYNDROME; EPIDEMIOLOGIC EVIDENCE;
   DAYTIME SLEEPINESS; HYPERTENSION; POPULATION; PREVALENCE; DEPRESSION;
   MORTALITY; CYTOKINES
AB Study objectives Insomnia disorders as well as cardiometabolic disorders are highly prevalent in the psychiatric population compared to the general population. We aimed to investigate their association and evolution over time in a Swiss psychiatric cohort. Methods Data for 2861 patients (8954 observations) were obtained from two prospective cohorts (PsyMetab and PsyClin) with metabolic parameters monitored routinely during psychotropic treatment. Insomnia disorders were based on the presence of ICD-10 "F51.0" diagnosis (non-organic insomnia), the prescription of sedatives before bedtime or the discharge letter. Metabolic syndrome was defined using the International Diabetes Federation definition, while the 10-year risk of cardiovascular event or death was assessed using the Framingham Risk Score and the Systematic Coronary Risk Estimation, respectively. Results Insomnia disorders were observed in 30% of the cohort, who were older, predominantly female, used more psychotropic drugs carrying risk of high weight gain (olanzapine, clozapine, valproate) and were more prone to suffer from schizoaffective or bipolar disorders. Multivariate analyses showed that patients with high body mass index (OR = 2.02, 95%CI [1.51-2.72] for each ten-kg/m(2) increase), central obesity (OR = 2.20, [1.63-2.96]), hypertension (OR = 1.86, [1.23-2.81]), hyperglycemia (OR = 3.70, [2.16-6.33]), high density lipoprotein hypocholesterolemia in women (OR = 1.51, [1.17-1.95]), metabolic syndrome (OR = 1.84, [1.16-2.92]) and higher 10-year risk of death from cardiovascular diseases (OR = 1.34, [1.17-1.53]) were more likely to have insomnia disorders. Time and insomnia disorders were associated with a deterioration of cardiometabolic parameters. Conclusions Insomnia disorders are significantly associated with metabolic worsening and risk of death from cardiovascular diseases in psychiatric patients.
C1 [Laaboub, Nermine; Dubath, Celine; Sibailly, Guibet; Grosu, Claire; Piras, Marianna; Ansermot, Nicolas; Crettol, Severine; Vandenberghe, Frederik; Grandjean, Carole; Delacretaz, Aurelie; Eap, Chin B.] Univ Lausanne, Lausanne Univ Hosp, Dept Psychiat, Unit Pharmacogenet & Clin Psychopharmacol, 1008 Prilly, Lausanne, Switzerland.
   [Ranjbar, Setareh] Univ Lausanne, Univ Lausanne Hosp, Dept Psychiat, Ctr Psychiat Epidemiol & Psychopathol, Lausanne, Switzerland.
   [Delessert, Didier] Univ Lausanne, Univ Lausanne Hosp, Dept Psychiat, Prison Med & Psychiat Serv, Lausanne, Switzerland.
   [Richard-Lepouriel, Helene] Univ Hosp Geneva, Dept Psychiat, Unit Mood Disorders, Geneva, Switzerland.
   [Delacretaz, Aurelie] Les Toises Psychiat & Psychotherapy Ctr, Lausanne, Switzerland.
   [Plessen, Kerstin Jessica] Univ Lausanne, Univ Lausanne Hosp, Dept Psychiat, Serv Child & Adolescent Psychiat, Lausanne, Switzerland.
   [von Gunten, Armin] Univ Lausanne, Univ Lausanne Hosp, Dept Psychiat, Serv Old Age Psychiat, Lausanne, Switzerland.
   [Conus, Philippe] Univ Lausanne, Univ Lausanne Hosp, Dept Psychiat, Serv Gen Psychiat, Lausanne, Switzerland.
   [Eap, Chin B.] Univ Lausanne, Univ Lausanne Hosp, Dept Psychiat, Serv Gen Psychiat, Lausanne, Switzerland.
   [Eap, Chin B.] Univ Lausanne, Ctr Res & Innovat Clin Pharmaceut Sci, Lausanne, Switzerland.
   Univ Lausanne, Univ Geneva, Inst Pharmaceut Sci Western Switzerland, Lausanne, Switzerland.
C3 University of Lausanne; University of Lausanne; Centre Hospitalier
   Universitaire Vaudois (CHUV); University of Lausanne; Centre Hospitalier
   Universitaire Vaudois (CHUV); University of Geneva; University of
   Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); University of
   Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); University of
   Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); University of
   Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); University of
   Lausanne; University of Lausanne; University of Geneva
RP Eap, CB (corresponding author), Univ Lausanne, Lausanne Univ Hosp, Dept Psychiat, Unit Pharmacogenet & Clin Psychopharmacol, 1008 Prilly, Lausanne, Switzerland.
EM chin.eap@chuv.ch44
RI Frederik, Vandenberghe/IQW-5168-2023; Richard-Lepouriel,
   Hélène/HLX-8031-2023; Ranjbar, Setareh/KRP-6906-2024
OI LAABOUB, Nermine/0000-0001-8029-2418; Grandjean,
   Carole/0009-0002-0460-9182; Richard-Lepouriel,
   Helene/0000-0002-0778-3728; Vandenberghe, Frederik/0000-0002-8964-2047;
   Ranjbar, Setareh/0000-0002-0238-2976
FU Swiss National Research Foundation [320030-120686, 324730-144064,
   320030-173211, 320030-200602]; Swiss National Science Foundation (SNF)
   [320030_173211, 320030_200602] Funding Source: Swiss National Science
   Foundation (SNF)
FX This work has been funded in part by the Swiss National Research
   Foundation (CE and PC: 320030-120686, 324730-144064, and 320030-173211;
   CBE, PC and KJP: 320030-200602). The funding sources had no role in the
   writing of the manuscript or in the decision to submit it for
   publication.
CR Adamantidis A, 2008, TRENDS ENDOCRIN MET, V19, P362, DOI 10.1016/j.tem.2008.08.007
   Akbaraly TN, 2015, AM J GERIAT PSYCHIAT, V23, P818, DOI 10.1016/j.jagp.2014.10.001
   Åkerstedt T, 2017, EUR J EPIDEMIOL, V32, P881, DOI 10.1007/s10654-017-0297-0
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Anderson TJ, 2016, CAN J CARDIOL, V32, P1263, DOI 10.1016/j.cjca.2016.07.510
   Bacon SL, 2014, INT J HYPERTENS, V2014, DOI 10.1155/2014/953094
   Balhara Yatan Pal Singh, 2011, Indian J Endocrinol Metab, V15, P274, DOI 10.4103/2230-8210.85579
   Barbagallo M, 1997, DIABETES METAB, V23, P281
   Chemerinski E, 2002, COMPR PSYCHIAT, V43, P393, DOI 10.1053/comp.2002.34627
   Conroy RM, 2003, EUR HEART J, V24, P987, DOI 10.1016/S0195-668X(03)00114-3
   Contrada R., 2010, The handbook of stress science: Biology, psychology, and health
   Costemale-Lacoste JF, 2020, J AFFECT DISORDERS, V264, P513, DOI 10.1016/j.jad.2019.11.084
   Costemale-Lacoste JF, 2017, J AFFECT DISORDERS, V217, P159, DOI 10.1016/j.jad.2017.04.011
   De Hert M, 2018, DIALOGUES CLIN NEURO, V20, P31, DOI 10.31887/DCNS.2018.20.1/mdehert
   Di Dalmazi G, 2015, J CLIN ENDOCR METAB, V100, P3529, DOI 10.1210/JC.2015-1992
   Dubath C, 2020, J CLIN PSYCHIAT, V81, DOI 10.4088/JCP.19m12796
   Gallicchio L, 2009, J SLEEP RES, V18, P148, DOI 10.1111/j.1365-2869.2008.00732.x
   Gamaldo CE, 2012, NEUROL CLIN, V30, P1313, DOI 10.1016/j.ncl.2012.08.007
   Gami AS, 2003, ENDOCRIN METAB CLIN, V32, P869, DOI 10.1016/S0889-8529(03)00069-0
   Gangwisch JE, 2009, OBES REV, V10, P37, DOI 10.1111/j.1467-789X.2009.00663.x
   Grandner MA, 2012, J SLEEP RES, V21, P427, DOI 10.1111/j.1365-2869.2011.00990.x
   Gross G, 2020, CHRONOBIOL INT, V37, P712, DOI 10.1080/07420528.2020.1725542
   Haba-Rubio J, 2015, SLEEP, V38, P391, DOI 10.5665/sleep.4496
   Huhn M, 2019, LANCET, V394, P939, DOI [10.1016/S0140-6736(19)31135-3, 10.1176/appi.focus.18306]
   Jayatilleke N, 2017, EUR PSYCHIAT, V43, P109, DOI 10.1016/j.eurpsy.2017.02.487
   Kaneita Y, 2008, SLEEP, V31, P645, DOI 10.1093/sleep/31.5.645
   Khandelwal Deepak, 2017, Indian J Endocrinol Metab, V21, P758, DOI 10.4103/ijem.IJEM_156_17
   Kiwan N, 2019, NEUROPSYCH DIS TREAT, V15, P2035, DOI 10.2147/NDT.S207987
   Krishnan V, 2006, CURR OPIN PULM MED, V12, P383, DOI 10.1097/01.mcp.0000245705.69440.6a
   Laaboub N, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.756403
   Ma T, 2021, J FORENSIC PSYCHI PS, V32, P281, DOI 10.1080/14789949.2020.1859588
   Mahmood A, 2022, SLEEP, V45, DOI 10.1093/sleep/zsac019
   Malan-Müller S, 2016, SCHIZOPHR RES, V170, P1, DOI 10.1016/j.schres.2015.11.011
   Marieb E.N., 2010, HUMAN ANATOMY PHYSL, V8th, DOI [10. 1007/BF00845519, DOI 10.1007/BF00845519]
   Marques-Vidal P, 2008, EUR J CARDIOV PREV R, V15, P402, DOI 10.1097/HJR.0b013e3282fb040f
   Marques-Vidal P, 2009, INT J CARDIOL, V133, P346, DOI 10.1016/j.ijcard.2008.01.004
   MELLINGER GD, 1985, ARCH GEN PSYCHIAT, V42, P225, DOI 10.1001/archpsyc.1985.01790260019002
   Monahan K, 2011, CURR OPIN CARDIOL, V26, P541, DOI 10.1097/HCO.0b013e32834b806a
   Muscogiuri G, 2019, CRIT REV FOOD SCI, V59, P2158, DOI 10.1080/10408398.2018.1506979
   Ohayon MM, 2011, EPIDEMIOLOGICAL OVER, P1
   Park SC, 2013, PSYCHIAT INVEST, V10, P373, DOI 10.4306/pi.2013.10.4.373
   Penninx BWJH, 2017, NEUROSCI BIOBEHAV R, V74, P277, DOI 10.1016/j.neubiorev.2016.07.003
   Rajan TM, 2017, J POSTGRAD MED, V63, P182, DOI 10.4103/jpgm.JPGM_712_16
   Resta O, 2003, J INTERN MED, V253, P536, DOI 10.1046/j.1365-2796.2003.01133.x
   Santos RVT, 2007, SLEEP MED REV, V11, P231, DOI 10.1016/j.smrv.2007.03.003
   Sateia MJ, 2014, CHEST, V146, P1387, DOI 10.1378/chest.14-0970
   Shan ZL, 2015, DIABETES CARE, V38, P529, DOI 10.2337/dc14-2073
   Sjöström N, 2007, SLEEP, V30, P91
   Smiley A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112582
   Sofi F, 2014, EUR J PREV CARDIOL, V21, P57, DOI 10.1177/2047487312460020
   Spiegel K, 2005, J APPL PHYSIOL, V99, P2008, DOI 10.1152/japplphysiol.00660.2005
   Sunderajan P, 2010, CNS SPECTRUMS, V15, P394, DOI 10.1017/S1092852900029266
   Taheri S, 2004, PLOS MED, V1, P210, DOI 10.1371/journal.pmed.0010062
   Thornicroft G, 2011, BRIT J PSYCHIAT, V199, P441, DOI 10.1192/bjp.bp.111.092718
   Vgontzas AN, 2001, J CLIN ENDOCR METAB, V86, P3787, DOI 10.1210/jc.86.8.3787
   Vgontzas AN, 1997, J CLIN ENDOCR METAB, V82, P1313, DOI 10.1210/jc.82.5.1313
   Visseren FLJ, 2021, EUR HEART J, V42, P3227, DOI 10.1093/eurheartj/ehab484
   Wang QJ, 2012, HYPERTENS RES, V35, P1012, DOI 10.1038/hr.2012.91
   Xi B, 2014, SLEEP MED REV, V18, P293, DOI 10.1016/j.smrv.2013.06.001
   Xiao Qian, 2016, BMC Obes, V3, P48
   Yuan S, 2021, EUR J EPIDEMIOL, V36, P393, DOI 10.1007/s10654-021-00737-5
   Zhang WJ, 2021, SLEEP MED, V83, P168, DOI 10.1016/j.sleep.2021.03.030
NR 62
TC 14
Z9 16
U1 1
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD MAY 17
PY 2022
VL 22
IS 1
AR 342
DI 10.1186/s12888-022-03983-3
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 1I0ZD
UT WOS:000796965400001
PM 35581641
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Solomon, A
   Christian, BF
   Norton, GR
   Woodiwiss, AJ
   Dessein, PH
AF Solomon, Ahmed
   Christian, Berenice F.
   Norton, Gavin R.
   Woodiwiss, Angela J.
   Dessein, Patrick H.
TI Risk Factor Profiles for Atherosclerotic Cardiovascular Disease in Black
   and Other Africans with Established Rheumatoid Arthritis
SO JOURNAL OF RHEUMATOLOGY
LA English
DT Article
DE ATHEROSCLEROTIC CARDIOVASCULAR DISEASE RISK; ETHNIC ORIGIN;
   EPIDEMIOLOGICAL TRANSITION; RHEUMATOID ARTHRITIS
ID CORONARY-HEART-DISEASE; MYOCARDIAL-INFARCTION; SUBCLINICAL
   ATHEROSCLEROSIS; METABOLIC SYNDROME; HEALTH-INSURANCE; PULSE PRESSURE;
   BLOOD-PRESSURE; VASCULAR RISK; MORTALITY; IMPACT
AB Objective. Black Africans reportedly experience a distinctly low risk for atherosclerotic cardiovascular disease (CVD). We investigated whether this protection was present among Africans with established rheumatoid arthritis (RA).
   Methods. We determined disparities in CVD risk factor profiles (major conventional: hypertension, dyslipidemia, smoking, and diabetes; other conventional: underweight, obesity, metabolic syndrome, chronic kidney disease, alcohol consumption, tension, depression, and body height; nonconventional: rheumatoid factor status and markers of inflammation) and arterial stiffness (brachial pulse pressure) between 291 black and 335 other (229 white, 64 Asian, and 42 mixed ancestry) consecutive Africans with RA in multivariable regression models.
   Results. After adjusting for demographic characteristics and healthcare sector attendance, black Africans had more prevalent hypertension (OR 1.76, p = 0.01) and diabetes (OR 1.90, p = 0.07), smoked less frequently (OR 0.12, p < 0.0001), and had concurrent lower total and high-density lipoprotein cholesterol concentrations that resulted in unaltered atherogenic indices (p = 0.2) than the other participants in the study. These findings translated into global scores for major conventional risk factor-mediated future CVD event rates that were not reduced in black patients. Proportions of individual metabolic syndrome components differed between black and other patients but their total numbers of metabolic risk factors (p = 0.4) and metabolic syndrome frequencies (OR 1.44, p = 0.1) were similar. Black ethnicity did not independently associate with rheumatoid factor status, markers of inflammation, and brachial pulse pressures.
   Conclusion. The overall conventional and nonconventional atherosclerotic CVD risk burdens and arterial stiffness were not reduced in black patients with RA. CVD risk should be assessed and managed independent of ethnic origin and epidemiological transition stage in RA. (First Release March 15 2010; J Rheumatol 2010;37:953-60; doi:10.3899/jrheum.091032)
C1 [Solomon, Ahmed; Christian, Berenice F.; Dessein, Patrick H.] Univ Witwatersrand, Dept Rheumatol, ZA-2050 Johannesburg, South Africa.
C3 University of Witwatersrand
RP Dessein, PH (corresponding author), POB 1012, ZA-2109 Johannesburg, South Africa.
EM Dessein@telkomsa.net
RI Dessein, Patrick/AAL-2986-2020
OI Norton, Gavin/0000-0001-6416-6104; , Angela/0000-0003-2555-4125
FU Medical Research Council
FX Supported in part by a Medical Research Council grant.
CR ARNETT FC, 1988, ARTHRITIS RHEUM-US, V31, P315, DOI 10.1002/art.1780310302
   Chung CP, 2008, ATHEROSCLEROSIS, V196, P756, DOI 10.1016/j.atherosclerosis.2007.01.004
   Clark LT, 2005, MED CLIN N AM, V89, P977, DOI 10.1016/j.mcna.2005.05.001
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Conroy RM, 2003, EUR HEART J, V24, P987, DOI 10.1016/S0195-668X(03)00114-3
   Coovadia H, 2009, LANCET, V374, P817, DOI 10.1016/S0140-6736(09)60951-X
   del Rincón I, 2005, ARTHRITIS RHEUM-US, V52, P3413, DOI 10.1002/art.21397
   Dessein PH, 2007, J RHEUMATOL, V34, P943
   Dessein PH, 2006, J RHEUMATOL, V33, P2425
   Dessein PH, 2006, ARTHRITIS RHEUM-US, V54, P2765, DOI 10.1002/art.22053
   Dessein PH, 2005, J RHEUMATOL, V32, P435
   Dessein PH, 2009, J RHEUMATOL, V36, P1357, DOI 10.3899/jrheum.090288
   Dessein PH, 2005, ARTHRITIS RES THER, V7, pR634, DOI 10.1186/ar1717
   FANG J, 1995, J HYPERTENS, V13, P413
   Fang J, 2000, BLOOD PRESSURE, V9, P260, DOI 10.1080/080370500448641
   Ferris WF, 2005, HORM METAB RES, V37, P695, DOI 10.1055/s-2005-870580
   Gazes PC, 2008, AM J CARDIOL, V102, P1514, DOI 10.1016/j.amjcard.2008.07.042
   Gonzalez A, 2008, ANN RHEUM DIS, V67, P64, DOI 10.1136/ard.2006.059980
   Gonzalez-Gay MA, 2005, SEMIN ARTHRITIS RHEU, V35, P8, DOI 10.1016/j.semarthrit.2005.03.004
   Grundy SM, 2005, CIRCULATION, V112, pE285, DOI 10.1161/CIRCULATIONAHA.105.169405
   Iren UT, 2005, J RHEUMATOL, V32, P602
   Kirigia JM, 2005, BMC HEALTH SERV RES, V5, DOI 10.1186/1472-6963-5-17
   Kremers HM, 2004, ARTHRITIS RHEUM-US, V50, P3450, DOI 10.1002/art.20612
   Levey AS, 1999, ANN INTERN MED, V130, P461, DOI 10.7326/0003-4819-130-6-199903160-00002
   Lewington S, 2007, LANCET, V370, P1829, DOI 10.1016/S0140-6736(07)61778-4
   Marmot MG, 1997, LANCET, V350, P235, DOI 10.1016/S0140-6736(97)04244-X
   Mayosi BM, 2009, LANCET, V374, P934, DOI 10.1016/S0140-6736(09)61087-4
   MEENAN RF, 1982, ARTHRITIS RHEUM-US, V25, P1048, DOI 10.1002/art.1780250903
   Oosthuizen W, 2002, SAMJ S AFR MED J, V92, P723
   Opie LH, 2005, CIRCULATION, V112, P3562, DOI 10.1161/CIRCULATIONAHA.105.539569
   PENISTON RL, 1989, J NATL MED ASSOC, V81, P591
   Radovits BJ, 2009, ANN RHEUM DIS, V68, P1271, DOI 10.1136/ard.2008.089862
   Sattar N, 2003, CIRCULATION, V108, P2957, DOI 10.1161/01.CIR.0000099844.31524.05
   Scherrer JF, 2009, GEN HOSP PSYCHIAT, V31, P353, DOI 10.1016/j.genhosppsych.2009.04.001
   Shisana O, 2006, SAMJ S AFR MED J, V96, P814
   Sliwa K, 2008, LANCET, V371, P915, DOI 10.1016/S0140-6736(08)60417-1
   Sobngwi E, 2001, DIABETES METAB, V27, P628
   Solomon A, 2005, SEMIN ARTHRITIS RHEU, V35, P122, DOI 10.1016/j.semarthrit.2005.05.005
   Solomon DH, 2003, CIRCULATION, V107, P1303, DOI 10.1161/01.CIR.0000054612.26458.B2
   SOLOMON L, 1975, ANN RHEUM DIS, V34, P128, DOI 10.1136/ard.34.2.128
   Stamatelopoulos KS, 2009, ARTERIOSCL THROM VAS, V29, P1702, DOI 10.1161/ATVBAHA.109.190108
   Stavropoulos-Kalinoglou A, 2007, ANN RHEUM DIS, V66, P1316, DOI 10.1136/ard.2006.060319
   Steyn K, 2005, CIRCULATION, V112, P3554, DOI 10.1161/CIRCULATIONAHA.105.563452
   Sumner AE, 2008, ATHEROSCLEROSIS, V196, P696, DOI 10.1016/j.atherosclerosis.2006.12.018
   Thorogood M, 2007, BMC PUBLIC HEALTH, V7, DOI 10.1186/1471-2458-7-326
   van Halm VP, 2009, ANN RHEUM DIS, V68, P1395, DOI 10.1136/ard.2008.094151
   Vorster HH, 2002, PUBLIC HEALTH NUTR, V5, P239, DOI 10.1079/PHN2001299
   Wolfe F, 2003, J RHEUMATOL, V30, P36
   YANCY CW, 2007, MEDGENMED, V9, P189
   Yusuf S, 2001, CIRCULATION, V104, P2746, DOI 10.1161/hc4601.099487
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
NR 51
TC 18
Z9 18
U1 0
U2 4
PU J RHEUMATOL PUBL CO
PI TORONTO
PA 365 BLOOR ST E, STE 901, TORONTO, ONTARIO M4W 3L4, CANADA
SN 0315-162X
EI 1499-2752
J9 J RHEUMATOL
JI J. Rheumatol.
PD MAY
PY 2010
VL 37
IS 5
BP 953
EP 960
DI 10.3899/jrheum.091032
PG 8
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 596PH
UT WOS:000277696700014
PM 20231201
OA Bronze
DA 2025-06-11
ER

PT J
AU Chen, H
   Hemmingsson, T
   Janszky, I
   Rostila, M
   Forsell, Y
   Meng, LH
   Liang, YJ
   László, KD
AF Chen, Hua
   Hemmingsson, Tomas
   Janszky, Imre
   Rostila, Mikael
   Forsell, Yvonne
   Meng, Linghui
   Liang, Yajun
   Laszlo, Krisztina D.
TI Death of a parent during childhood and blood pressure in youth: a
   population-based cohort study of Swedish men
SO BMJ OPEN
LA English
DT Article
DE hypertension; epidemiology; mental health
ID CORONARY-HEART-DISEASE; LATE ADOLESCENCE; METABOLIC SYNDROME;
   RISK-FACTORS; MIDDLE-AGE; HEALTH; STRESS; HYPERTENSION; EXPERIENCES;
   ADULTHOOD
AB ObjectiveCompelling evidence suggests that childhood adversities are associated with an increased risk of hypertension in middle age and old age. The link between childhood adversities and blood pressure in youth is less clear. In this cohort study, we examined the association between death of a parent during childhood and blood pressure in early adulthood in men.SettingSweden.ParticipantsWe studied 48 624 men born in 1949-1951 who participated in the compulsory military conscription in 1969/1970 in Sweden. Information on death of a parent during childhood was obtained from population-based registers. Information on covariates was obtained from the questionnaire and the clinical examination completed at conscription and from population-based registers.Outcome measuresBlood pressure was measured at conscription according to standard procedures.ResultsThe multivariable least square means of systolic and diastolic blood pressure did not differ between bereaved (128.25 (127.04-129.46) and 73.86 (72.89-74.84) mm Hg) and non-bereaved study participants (128.02 (126.86-129.18) and 73.99 (73.06-74.93) mm Hg). Results were similar when considering the cause of the parent's death, the gender of the deceased parent or the child's age at loss. Loss of a parent in childhood tended to be associated with an increased hypertension risk (OR and 95% CI: 1.10 (1 to 1.20)); the association was present only in case of natural deaths.ConclusionWe found no strong support for the hypothesis that stress following the loss of a parent during childhood is associated with blood pressure or hypertension in youth in men.
C1 [Chen, Hua; Janszky, Imre; Forsell, Yvonne; Meng, Linghui; Liang, Yajun; Laszlo, Krisztina D.] Karolinska Inst, Dept Global Publ Hlth, Stockholm, Sweden.
   [Hemmingsson, Tomas; Rostila, Mikael] Stockholm Univ, Dept Publ Hlth Sci, Stockholm, Sweden.
   [Hemmingsson, Tomas] Karolinska Inst, Inst Environm Med, Stockholm, Sweden.
   [Janszky, Imre] Norwegian Univ Sci & Technol, Fac Med, Dept Publ Hlth & Gen Practice, Trondheim, Norway.
   [Rostila, Mikael] Stockholm Univ, Ctr Hlth Equ Studies, Stockholm, Sweden.
   [Rostila, Mikael] Karolinska Inst, Stockholm, Sweden.
   [Forsell, Yvonne] Stockholm Cty Council, Ctr Epidemiol & Community Med, Stockholm, Sweden.
   [Meng, Linghui] Capital Inst Pediat, Stat Off, Beijing, Peoples R China.
C3 Karolinska Institutet; Stockholm University; Karolinska Institutet;
   Norwegian University of Science & Technology (NTNU); Stockholm
   University; Karolinska Institutet; Region Stockholm; Capital Institute
   of Pediatrics (CIP)
RP Chen, H (corresponding author), Karolinska Inst, Dept Global Publ Hlth, Stockholm, Sweden.
EM hua.chen@ki.se
RI Forsell, Yvonne/ABB-8879-2020
FU Swedish Council for Working Life and Social Research [2015-00837];
   Karolinska Institutet's Research Foundation [2018-01924]; China
   Scholarship Council [201700260296]; Forte [2015-00837] Funding Source:
   Forte
FX The study was supported by the Swedish Council for Working Life and
   Social Research (grant number: 2015-00837), by Karolinska Institutet's
   Research Foundation (grant number: 2018-01924) and by the China
   Scholarship Council (grant number: 201700260296).
CR Alciati A, 2013, STRESS HEALTH, V29, P5, DOI 10.1002/smi.1435
   Anderson EL, 2017, INT J EQUITY HEALTH, V16, DOI 10.1186/s12939-017-0656-1
   [Anonymous], LIFE COURSE APPROACH
   Berg L, 2016, J CHILD PSYCHOL PSYC, V57, P1092, DOI 10.1111/jcpp.12560
   Berg L, 2014, PEDIATRICS, V133, P682, DOI 10.1542/peds.2013-2771
   Breslau N, 2004, J URBAN HEALTH, V81, P530, DOI 10.1093/jurban/jth138
   Britton KA, 2009, EUR J HEART FAIL, V11, P1129, DOI 10.1093/eurjhf/hfp141
   Brunner E, 2002, STRESS AND THE HEART: PSYCHOSOCIAL PATHWAYS TO CORONARY HEART DISEASE, P181
   Buckley T, 2011, HEART LUNG CIRC, V20, P91, DOI 10.1016/j.hlc.2010.10.073
   Chen H, 2020, PSYCHOSOM MED, V82, P810, DOI 10.1097/PSY.0000000000000861
   Chen RQ, 2018, CLIN EPIDEMIOL, V10, P593, DOI 10.2147/CLEP.S152210
   Chen XL, 2008, CIRCULATION, V117, P3171, DOI 10.1161/CIRCULATIONAHA.107.730366
   Di Pilla M, 2016, MATURITAS, V93, P58, DOI 10.1016/j.maturitas.2016.06.003
   Dietz LJ, 2018, J PSYCHOSOM RES, V113, P58, DOI 10.1016/j.jpsychores.2018.07.016
   Doom JR, 2017, SOC SCI MED, V188, P166, DOI 10.1016/j.socscimed.2017.06.044
   Dowdney L, 2000, J CHILD PSYCHOL PSYC, V41, P819, DOI 10.1111/1469-7610.00670
   Falkner B, 2013, J PEDIATR-US, V162, P94, DOI 10.1016/j.jpeds.2012.06.009
   Falkstedt D, 2007, INT J OBESITY, V31, P777, DOI 10.1038/sj.ijo.0803480
   Falkstedt D, 2008, J HYPERTENS, V26, P1313, DOI 10.1097/HJH.0b013e3282ffb17e
   Falkstedt D, 2011, EUR J PUBLIC HEALTH, V21, P713, DOI 10.1093/eurpub/ckq158
   Felitti Vincent J, 2002, Perm J, V6, P44
   Flint AC, 2019, NEW ENGL J MED, V381, P243, DOI 10.1056/NEJMoa1803180
   Flynn JT, 2017, PEDIATRICS, V140, DOI [10.1542/peds.2017-3035, 10.1542/peds.2017-1904]
   Franklin BA, 2018, J CARDIOPULM REHABIL, V38, P353, DOI 10.1097/HCR.0000000000000376
   Fuchs A, 2016, PSYCHOPATHOLOGY, V49, P211, DOI 10.1159/000445439
   Geulayov G, 2012, PSYCHOL MED, V42, P1567, DOI 10.1017/S0033291711002753
   Gooding HC, 2016, J PEDIATR PSYCHOL, V41, P5, DOI 10.1093/jpepsy/jsv040
   Hamdan S, 2013, J CLIN PSYCHIAT, V74, P828, DOI 10.4088/JCP.13m08391
   Hamdan S, 2012, ARCH PEDIAT ADOL MED, V166, P216, DOI 10.1001/archpediatrics.2011.682
   Hjern A., 2017, CHILDREN NEXT KIN SW
   Hughes K, 2017, LANCET PUBLIC HEALTH, V2, pE356, DOI 10.1016/S2468-2667(17)30118-4
   Islam MS, 2017, ADV EXP MED BIOL, V956, P1, DOI 10.1007/5584_2017_30
   Kawabe H, 2019, HYPERTENS RES, V42, P935, DOI 10.1038/s41440-019-0229-3
   Kirwin KM, 2005, J CHILD ADOL PS NURS, V18, P62, DOI 10.1111/j.1744-6171.2005.00002.x
   Kit BK, 2015, JAMA PEDIATR, V169, P272, DOI 10.1001/jamapediatrics.2014.3216
   Koehn AJ, 2018, ATTACH HUM DEV, V20, P378, DOI 10.1080/14616734.2017.1408131
   Larsson D, 2002, SCAND J PUBLIC HEALT, V30, P259, DOI 10.1080/14034940210133997
   Li J, 2014, PLOS MED, V11, DOI 10.1371/journal.pmed.1001679
   Lim SS, 2012, LANCET, V380, P2224, DOI 10.1016/S0140-6736(12)61766-8
   Lindgren M, 2018, INT J CARDIOL, V259, P109, DOI 10.1016/j.ijcard.2018.01.110
   Liu MY, 2017, NEUROL RES, V39, P573, DOI 10.1080/01616412.2017.1317904
   Luecken LJ, 2012, INT J PSYCHOPHYSIOL, V84, P172, DOI 10.1016/j.ijpsycho.2012.02.003
   Luecken LJ, 2009, DEV PSYCHOL, V45, P296, DOI 10.1037/a0013888
   Luecken LJ, 1998, PSYCHOSOM MED, V60, P765, DOI 10.1097/00006842-199811000-00021
   Merai R, 2016, MMWR-MORBID MORTAL W, V65, P1261, DOI 10.15585/mmwr.mm6545a3
   Muntner P, 2019, HYPERTENSION, V73, pE35, DOI 10.1161/HYP.0000000000000087
   Noubiap JJ, 2017, LANCET PUBLIC HEALTH, V2, pE375, DOI 10.1016/S2468-2667(17)30123-8
   Obi IE, 2019, BRIT J PHARMACOL, V176, P1932, DOI 10.1111/bph.14576
   Oliveira AJ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0095201
   Pabayo R, 2014, J URBAN HEALTH, V91, P335, DOI 10.1007/s11524-013-9828-5
   Parrish C, 2013, PREV CHRONIC DIS, V10, DOI 10.5888/pcd10.130193
   Rostila M, 2017, AM J EPIDEMIOL, V185, P1247, DOI 10.1093/aje/kww126
   Rostila M, 2015, SOC SCI MED, V131, P190, DOI 10.1016/j.socscimed.2015.03.012
   Rovio SP, 2017, J AM COLL CARDIOL, V69, P2279, DOI 10.1016/j.jacc.2017.02.060
   Schooling CM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019675
   Sherr L, 2014, CHILD WELFARE, V93, P149
   Smith KR, 2014, SOC SCI MED, V119, P180, DOI 10.1016/j.socscimed.2013.11.054
   Springer KW, 2007, CHILD ABUSE NEGLECT, V31, P517, DOI 10.1016/j.chiabu.2007.01.003
   Stein DJ, 2010, ANN CLIN PSYCHIATRY, V22, P19
   Stroebe M, 2007, LANCET, V370, P1960, DOI 10.1016/S0140-6736(07)61816-9
   Su SY, 2015, CIRCULATION, V131, P1674, DOI 10.1161/CIRCULATIONAHA.114.013104
   Su SY, 2014, HYPERTENSION, V64, P201, DOI 10.1161/HYPERTENSIONAHA.113.02755
   Suglia SF, 2018, CIRCULATION, V137, pE15, DOI 10.1161/CIR.0000000000000536
   Sun SS, 2007, PEDIATRICS, V119, P237, DOI 10.1542/peds.2006-2543
   Sundin PO, 2014, AM J KIDNEY DIS, V64, P723, DOI 10.1053/j.ajkd.2014.06.019
   Sundström J, 2011, BMJ-BRIT MED J, V342, DOI 10.1136/bmj.d643
   Whelton PK, 2018, HYPERTENSION, V71, pE13, DOI [10.1161/HYP.0000000000000066, 10.1161/HYP.0000000000000065]
NR 67
TC 2
Z9 2
U1 1
U2 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD APR
PY 2021
VL 11
IS 4
AR e043657
DI 10.1136/bmjopen-2020-043657
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 3R2LR
UT WOS:000838750600001
PM 33903141
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Happell, B
   Platania-Phung, C
   Scott, D
AF Happell, B.
   Platania-Phung, C.
   Scott, D.
TI A systematic review of nurse physical healthcare for consumers utilizing
   mental health services
SO JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING
LA English
DT Article
DE nursing; physical healthcare; planning; serious mental illness;
   systematic review
ID LIFE-STYLE INTERVENTION; WELL-BEING PROGRAM; RANDOMIZED-TRIAL; METABOLIC
   SYNDROME; WEIGHT MANAGEMENT; BIPOLAR DISORDER; OBESE-PATIENTS;
   OLDER-PEOPLE; RISK-FACTORS; ILLNESS
AB The poor physical health of people with serious mental illness presents a long-term public health issue that mental healthcare services, and their most representative group (nurses), can help address. For purposes of long-term planning in increasing the role of nurses in physical healthcare within mental healthcare services a systematic review was conducted of services and programmes where nurses conduct physical healthcare (such as physical health checks and health education). The most common types of physical healthcare represented in the literature were health education, screening, lifestyle programme delivery and co-ordination of care. Although evaluation of the programmes reviewed were all at a preliminary stage, they consistently demonstrated health benefits for consumers.
   AbstractPeople with serious mental illness have higher rates of physical illness and are more likely to experience premature death than the general population. Nurse-led strategies to improve physical healthcare in mental healthcare services could potentially reduce these inequalities. However the extent of nurse involvement in physical healthcare (such as physical risk screening, health education and care co-ordination) in mental health settings is not known. A systematic review was conducted on nurse-led physical healthcare reported for consumers with serious mental illness (SMI) in mental health services, and their benefits. Electronic literature bases (CINAHL, Proquest, PsychINFO and Web of Science) were systematically searched, in conjunction with a manual search of literature reviews on physical healthcare in mental health services. Articles were included if they: (a) were published in the last 10 years; (b) were English language; (c) involved physical healthcare of adult consumers receiving mental healthcare services; and (d) reported nurse involvement in physical healthcare. Forty articles were included in the review. The distribution of types of care were: health education (47%), screening and/or monitoring (33.3%), care co-ordination and management (33.3%), lifestyle programme delivery (30.5%), follow-up actions to screening results (25%) and registers and data administration (5.5%). Overall, the evaluation of nurse-based physical healthcare is in early stages. Thus far, they appear to have positive implications for consumers with SMI.
C1 [Happell, B.; Platania-Phung, C.; Scott, D.] Cent Queensland Univ, Inst Hlth & Social Sci Res, Ctr Mental Hlth Nursing Innovat, Rockhampton, Qld 4702, Australia.
   [Happell, B.] Cent Queensland Univ, Sch Nursing & Midwifery, Rockhampton, Qld 4702, Australia.
C3 Central Queensland University; Central Queensland University
RP Happell, B (corresponding author), Cent Queensland Univ, Rockhampton, Qld 4702, Australia.
EM b.happell@cqu.edu.au
RI Scott, David/AAE-5031-2021; Happell, Brenda/HSI-0570-2023
OI Happell, Brenda/0000-0002-7293-6583; Scott, David/0000-0001-5226-1972
FU Central Queensland University
FX The authors acknowledge the financial support for this work provided by
   Central Queensland University.
CR [Anonymous], INTRO MENTAL HLTH NU
   [Anonymous], 2003, BRIT J THERAPY REHAB, DOI DOI 10.12968/BJTR.2003.10.5.13544
   [Anonymous], 2006, PREVENTING CHRONIC D
   Barrowclough C, 2010, BMJ-BRIT MED J, V341, DOI 10.1136/bmj.c6325
   Bartels SJ, 2004, J AM GERIATR SOC, V52, pS249, DOI 10.1111/j.1532-5415.2004.52601.x
   Bartels SJ, 2004, COMMUNITY MENT HLT J, V40, P75, DOI 10.1023/B:COMH.0000015219.29172.64
   Bauer MS, 2006, PSYCHIAT SERV, V57, P927, DOI 10.1176/appi.ps.57.7.927
   Blank MB, 2011, PSYCHIAT SERV, V62, P1318, DOI 10.1176/ps.62.11.pss6211_1318
   Blythe J, 2012, INT J MENT HEALTH NU, V21, P193, DOI 10.1111/j.1447-0349.2011.00792.x
   Bonsaksen T, 2011, INT J THER REHABIL, V18, P91, DOI 10.12968/ijtr.2011.18.2.91
   Bradley AC, 2007, AUST NZ J PSYCHIAT, V41, P501, DOI 10.1080/00048670701332300
   Bradshaw T, 2012, INT J MENT HEALTH NU, V21, P266, DOI 10.1111/j.1447-0349.2012.00818.x
   Brown C, 2011, PSYCHIAT SERV, V62, P800, DOI 10.1176/ps.62.7.pss6207_0800
   Brunero S, 2009, INT J MENT HEALTH NU, V18, P144, DOI 10.1111/j.1447-0349.2009.00595.x
   Bushe CJ, 2008, BMC PSYCHIATRY, V8, DOI 10.1186/1471-244X-8-76
   Chadwick A, 2012, INT J MENT HEALTH NU, V21, P211, DOI 10.1111/j.1447-0349.2011.00807.x
   Chafetz L, 2004, NURS OUTLOOK, V52, P209, DOI 10.1016/S0029-6554(04)00066-1
   Chafetz L, 2008, J NERV MENT DIS, V196, P475, DOI 10.1097/NMD.0b013e31817738de
   De Hert M, 2010, EUR PSYCHIAT, V25, pS22, DOI 10.1016/S0924-9338(10)71702-8
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P138
   De Hert M, 2009, WORLD PSYCHIATRY, V8, P15
   Drew L, 2007, AUSTRALAS PSYCHIATRY, V15, P320, DOI 10.1080/10398560701320105
   Druss BG, 2010, AM J PSYCHIAT, V167, P151, DOI 10.1176/appi.ajp.2009.09050691
   Edward KL, 2010, ARCH PSYCHIAT NURS, V24, P46, DOI 10.1016/j.apnu.2009.04.009
   Faulkner G, 2002, J Psychiatr Ment Health Nurs, V9, P659, DOI 10.1046/j.1365-2850.2002.00520.x
   Feeley TH, 2004, PSYCHIATR REHABIL J, V27, P275, DOI 10.2975/27.2004.275.278
   Forsberg KA, 2008, NORD J PSYCHIAT, V62, P486, DOI 10.1080/08039480801985179
   Gartshore A, 2009, J PSYCHIATR MENT HLT, V16, P578, DOI 10.1111/j.1365-2850.2009.01408.x
   Gray R, 2012, INT J MENT HEALTH NU, V21, P191, DOI 10.1111/j.1447-0349.2012.00832.x
   Griffiths M, 2010, ARCH PSYCHIAT NURS, V24, P239, DOI 10.1016/j.apnu.2009.07.003
   Happell B, 2011, J PSYCHIATR MENT HLT, V18, P706, DOI 10.1111/j.1365-2850.2010.01666.x
   Happell B, 2012, INT J MENT HEALTH NU, V21, P236, DOI 10.1111/j.1447-0349.2012.00816.x
   Happell B, 2012, INT J MENT HEALTH NU, V21, P202, DOI 10.1111/j.1447-0349.2011.00799.x
   Hardy S, 2011, J PSYCHIATR MENT HLT, V18, P721, DOI 10.1111/j.1365-2850.2011.01722.x
   Haupt DW, 2006, EUR NEUROPSYCHOPHARM, V16, pS149, DOI 10.1016/j.euroneuro.2006.06.003
   Hogan Beverly K, 2007, Issues Ment Health Nurs, V28, P927, DOI 10.1080/01612840701493345
   Howard L, 2011, J PSYCHIATR MENT HLT, V18, P105, DOI 10.1111/j.1365-2850.2010.01642.x
   Iglesias-García C, 2010, J PSYCHIATR MENT HLT, V17, P849, DOI 10.1111/j.1365-2850.2010.01590.x
   Jordan S, 2002, J ADV NURS, V37, P155, DOI 10.1046/j.1365-2648.2002.02064.x
   Kilbourne AM, 2008, PSYCHIAT SERV, V59, P760, DOI 10.1176/appi.ps.59.7.760
   Lakeman R, 2012, INT J MENT HEALTH NU, V21, P394, DOI 10.1111/j.1447-0349.2012.00851.x
   Lambert TJR, 2009, MED J AUSTRALIA, V190, pS39
   Lawrence D, 2010, J PSYCHOPHARMACOL, V24, P61, DOI 10.1177/1359786810382058
   Lee SJ, 2008, J CLIN PSYCHIAT, V69, P555, DOI 10.4088/JCP.v69n0406
   Lewis M, 2010, J PSYCHIATR MENT HLT, V17, P651, DOI 10.1111/j.1365-2850.2010.01589.x
   Lindenmayer JP, 2009, J CLIN PSYCHIAT, V70, P1385, DOI 10.4088/JCP.08m04740yel
   Littrell KH, 2003, J NURS SCHOLARSHIP, V35, P237, DOI 10.1111/j.1547-5069.2003.00237.x
   McCandless F, 2003, J ADV NURS, V44, P42, DOI 10.1046/j.1365-2648.2003.02766.x
   McDevitt J, 2005, NURS CLIN N AM, V40, P779, DOI 10.1016/j.cnur.2005.08.004
   McKeown M., 2006, PRACT NURSE, V32, P15
   Mueser KT, 2010, J CONSULT CLIN PSYCH, V78, P561, DOI 10.1037/a0019629
   Muir-Cochrane E, 2006, J PSYCHIATR MENT HLT, V13, P447, DOI 10.1111/j.1365-2850.2006.01002.x
   Nash M., 2005, Mental Health Practice, V9, P20, DOI DOI 10.7748/MHP2005.12.9.4.20.C1896
   Nash M, 2011, J NURS MANAGE, V19, P360, DOI 10.1111/j.1365-2834.2011.01244.x
   O'Brien A, 2012, INT J MENT HEALTH NU, V21, P396, DOI 10.1111/j.1447-0349.2012.00854.x
   Ohlsen R, 2004, ACTA PSYCHIAT SCAND, V109, P156, DOI 10.1046/j.1600-0447.2003.00279.x
   Ohlsen R I, 2005, J Psychiatr Ment Health Nurs, V12, P614
   Osborn DPJ, 2010, BMC HEALTH SERV RES, V10, DOI 10.1186/1472-6963-10-61
   Park T, 2011, INT J MENT HEALTH NU, V20, P428, DOI 10.1111/j.1447-0349.2011.00747.x
   Porsdal V, 2010, BMC PSYCHIATRY, V10, DOI 10.1186/1471-244X-10-42
   Poulin MJ, 2007, AUST NZ J PSYCHIAT, V41, P980, DOI 10.1080/00048670701689428
   Pratt SI, 2008, AM J PSYCHIATR REHAB, V11, P41, DOI 10.1080/15487760701853193
   Prebble Kate, 2011, J Am Psychiatr Nurses Assoc, V17, P127, DOI 10.1177/1078390311399094
   Robson D, 2007, INT J NURS STUD, V44, P457, DOI 10.1016/j.ijnurstu.2006.07.013
   Shuel F, 2010, INT J NURS STUD, V47, P136, DOI 10.1016/j.ijnurstu.2009.06.003
   Smith S, 2007, INT J CLIN PRACT, V61, P1971, DOI 10.1111/j.1742-1241.2007.01605.x
   Smith S, 2007, EUR PSYCHIAT, V22, P413, DOI 10.1016/j.eurpsy.2007.07.002
   Wheeler AJ, 2010, COMMUNITY MENT HLT J, V46, P531, DOI 10.1007/s10597-009-9237-0
   Worley N K, 1990, Arch Psychiatr Nurs, V4, P108, DOI 10.1016/0883-9417(90)90017-F
NR 69
TC 22
Z9 24
U1 0
U2 31
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1351-0126
EI 1365-2850
J9 J PSYCHIATR MENT HLT
JI J. Psychiatr. Ment. Health Nurs.
PD FEB
PY 2014
VL 21
IS 1
BP 11
EP 22
DI 10.1111/jpm.12041
PG 12
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 278NA
UT WOS:000328895800002
PM 23419025
DA 2025-06-11
ER

PT J
AU Talari, HR
   Najafi, V
   Raygan, F
   Mirhosseini, N
   Ostadmohammadi, V
   Amirani, E
   Taghizadeh, M
   Hajijafari, M
   Shafabakhash, R
   Asemi, Z
AF Talari, Hamid Reza
   Najafi, Vahid
   Raygan, Fariba
   Mirhosseini, Naghmeh
   Ostadmohammadi, Vahidreza
   Amirani, Elaheh
   Taghizadeh, Mohsen
   Hajijafari, Mohammad
   Shafabakhash, Rana
   Asemi, Zatollah
TI Long-term vitamin D and high-dose n-3 fatty acids'
   supplementation improve markers of cardiometabolic risk in type 2
   diabetic patients with CHD (Publication with Expression of Concern. See
   vol. 127, pg. 158, 2022)
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article; Publication with Expression of Concern
DE Vitamin D supplementation; n-3 Fatty acids; Cardiometabolic risk; Type 2
   diabetes mellitus; Coronary heart disease
ID INTIMA-MEDIA THICKNESS; CORONARY-HEART-DISEASE; FLAXSEED OIL;
   DOUBLE-BLIND; TRANSCRIPTIONAL ACTIVATION; ENDOTHELIAL DYSFUNCTION;
   OXIDATIVE STRESS; ATHEROSCLEROSIS; INFLAMMATION; GLUCOSE
AB This study was performed to evaluate the effects of vitamin D and n-3 fatty acids' co-supplementation on markers of cardiometabolic risk in diabetic patients with CHD. This randomised, double-blinded, placebo-controlled trial was conducted among sixty-one vitamin D-deficient diabetic patients with CHD. At baseline, the range of serum 25-hydroxyvitamin D levels in study participants was 6 center dot 3-19 center dot 9 ng/ml. Subjects were randomly assigned into two groups either taking 50 000 IU vitamin D supplements every 2 weeks plus 2x 1000 mg/d n-3 fatty acids from flaxseed oil (n 30) or placebo (n 31) for 6 months. Vitamin D and n-3 fatty acids' co-supplementation significantly reduced mean (P = 0 center dot 01) and maximum levels of left carotid intima-media thickness (CIMT) (P = 0 center dot 004), and mean (P = 0 center dot 02) and maximum levels of right CIMT (P = 0 center dot 003) compared with the placebo. In addition, co-supplementation led to a significant reduction in fasting plasma glucose (beta -0 center dot 40 mmol/l; 95 % CI -0 center dot 77, -0 center dot 03; P = 0 center dot 03), insulin (beta -1 center dot 66 mu IU/ml; 95 % CI -2 center dot 43, -0 center dot 89; P < 0 center dot 001), insulin resistance (beta -0 center dot 49; 95 % CI -0 center dot 72, -0 center dot 25; P < 0 center dot 001) and LDL-cholesterol (beta -0 center dot 21 mmol/l; 95 % CI -0 center dot 41, -0 center dot 01; P = 0 center dot 04), and a significant increase in insulin sensitivity (beta +0 center dot 008; 95 % CI 0 center dot 004, 0 center dot 01; P = 0 center dot 001) and HDL-cholesterol (beta +0 center dot 09 mmol/l; 95 % CI 0 center dot 01, 0 center dot 17; P = 0 center dot 02) compared with the placebo. Additionally, high-sensitivity C-reactive protein (beta -1 center dot 56 mg/l; 95 % CI -2 center dot 65, -0 center dot 48; P = 0 center dot 005) was reduced in the supplemented group compared with the placebo group. Overall, vitamin D and n-3 fatty acids' co-supplementation had beneficial effects on markers of cardiometabolic risk.
C1 [Talari, Hamid Reza; Najafi, Vahid] Kashan Univ Med Sci, Dept Radiol, Kashan, Iran.
   [Raygan, Fariba] Kashan Univ Med Sci, Dept Cardiol, Sch Med, Kashan, Iran.
   [Mirhosseini, Naghmeh] Univ Saskatchewan, Sch Publ Hlth, Saskatoon, SK, Canada.
   [Ostadmohammadi, Vahidreza; Amirani, Elaheh; Taghizadeh, Mohsen; Shafabakhash, Rana; Asemi, Zatollah] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
   [Hajijafari, Mohammad] Kashan Univ Med Sci, Trauma Res Ctr, Kashan, Iran.
C3 University of Saskatchewan
RP Asemi, Z (corresponding author), Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
EM asemi_r@yahoo.com
RI asemi, zatollah/J-2677-2018; Hajijafari, Mohammad/H-4119-2017;
   Mirhosseini, Naghmeh/AAC-7730-2019; Raygan, Fariba/W-3349-2017;
   Taghizadeh, Mohsen/D-7784-2017; Ostadmohammadi, Vahidreza/A-6248-2018
OI Raygan, Fariba/0000-0003-3789-5584; Ostadmohammadi,
   Vahidreza/0000-0002-4633-5397
FU KAUMS, Iran
FX The present study was funded by a grant from the Vice-Chancellor for
   Research, KAUMS, Iran.
CR Abdali D, 2015, MED PRIN PRACT, V24, P201, DOI 10.1159/000375305
   Ainsworth BE, 2000, MED SCI SPORT EXER, V32, pS498, DOI 10.1097/00005768-200009001-00009
   Ajuwon KM, 2005, J NUTR, V135, P1841, DOI 10.1093/jn/135.8.1841
   Akash MSH, 2013, J CELL BIOCHEM, V114, P525, DOI 10.1002/jcb.24402
   Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
   An WS, 2012, NUTR RES, V32, P495, DOI 10.1016/j.nutres.2012.06.005
   Asemi Z, 2016, BRIT J NUTR, V116, P286, DOI 10.1017/S0007114516001847
   Babajafari S, 2018, BURNS, V44, P140, DOI 10.1016/j.burns.2017.05.014
   Baidal DA, 2016, EUR REV MED PHARMACO, V20, P3313
   Beckman JA, 2002, JAMA-J AM MED ASSOC, V287, P2570, DOI 10.1001/jama.287.19.2570
   Bots ML, 2016, CHINESE MED J-PEKING, V129, P215, DOI 10.4103/0366-6999.173500
   Chen HJ, 2003, J MOL CELL CARDIOL, V35, P769, DOI 10.1016/S0022-2828(03)00120-2
   CUNNANE SC, 1995, AM J CLIN NUTR, V61, P62, DOI 10.1093/ajcn/61.1.62
   CUNNANE SC, 1993, BRIT J NUTR, V69, P443, DOI 10.1079/BJN19930046
   de Boer IH, 2009, J AM SOC NEPHROL, V20, P1805, DOI 10.1681/ASN.2008111157
   de Oliveira PA, 2017, OBES SURG, V27, P2663, DOI 10.1007/s11695-017-2704-8
   Devarshi PP, 2013, GENES NUTR, V8, P329, DOI 10.1007/s12263-012-0326-2
   Dupasquier CMC, 2007, AM J PHYSIOL-HEART C, V293, pH2394, DOI 10.1152/ajpheart.01104.2006
   Einarson TR, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0728-6
   FRASER JD, 1990, CALCIFIED TISSUE INT, V46, P270, DOI 10.1007/BF02555007
   Gärtner V, 2008, CLIN NEPHROL, V70, P1
   Huang ZG, 2012, MOL CELL BIOCHEM, V363, P11, DOI 10.1007/s11010-011-1153-2
   Ingelsson E, 2007, JAMA-J AM MED ASSOC, V298, P776, DOI 10.1001/jama.298.7.776
   Jafari T, 2016, CLIN NUTR, V35, P1259, DOI 10.1016/j.clnu.2016.03.001
   Jangale Nivedita M, 2013, Food Chem, V141, P187, DOI 10.1016/j.foodchem.2013.03.001
   Jiang WL, 2016, CLIN CARDIOL, V39, P56, DOI 10.1002/clc.22473
   Kaplan M, 2008, J CARDIOVASC PHARM, V52, P324, DOI 10.1097/FJC.0b013e3181879d98
   Karakas Y, 2017, HEMODIAL INT, V21, P97, DOI 10.1111/hdi.12439
   Katakami N, 2014, J DIABETES INVEST, V5, P3, DOI 10.1111/jdi.12106
   Khandouzi N, 2019, EUR J CLIN NUTR, V73, P258, DOI 10.1038/s41430-018-0268-x
   Khosravi ZS, 2018, INT J PREVENTIVE MED, V9, DOI 10.4103/ijpvm.IJPVM_329_15
   Li XY, 2018, NUTRIENTS, V10, DOI 10.3390/nu10030375
   Liu XF, 2013, LIPIDS HEALTH DIS, V12, DOI 10.1186/1476-511X-12-109
   Luepker RV, 2003, CIRCULATION, V108, P2543, DOI 10.1161/01.CIR.0000100560.46946.EA
   Maestro B, 2002, CELL BIOCHEM FUNCT, V20, P227, DOI 10.1002/cbf.951
   Maestro B, 2000, ENDOCR J, V47, P383, DOI 10.1507/endocrj.47.383
   Mirfatahi M, 2016, INT UROL NEPHROL, V48, P1335, DOI 10.1007/s11255-016-1300-5
   Mousa A, 2018, NUTR REV, V76, P380, DOI 10.1093/nutrit/nux077
   Pisprasert V, 2013, DIABETES CARE, V36, P845, DOI 10.2337/dc12-0840
   Prasad K, 2008, ATHEROSCLEROSIS, V197, P34, DOI 10.1016/j.atherosclerosis.2007.07.043
   Prasad K, 2016, CURR PHARM DESIGN, V22, P214, DOI 10.2174/1381612822666151112151130
   RAPER NR, 1992, J AM COLL NUTR, V11, P304
   Remels AHV, 2009, AM J PHYSIOL-ENDOC M, V297, pE174, DOI 10.1152/ajpendo.90632.2008
   Ren GY, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030136
   Salekzamani S, 2017, ENDOCRINE, V57, P51, DOI 10.1007/s12020-017-1317-2
   Soleimani Z, 2017, J DIABETES COMPLICAT, V31, P1394, DOI 10.1016/j.jdiacomp.2017.06.010
   Soltanian N, 2018, NUTR METAB, V15, DOI 10.1186/s12986-018-0273-z
   Tatsch E, 2011, CLIN BIOCHEM, V44, P348, DOI 10.1016/j.clinbiochem.2010.12.011
   Trayhurn P, 2004, BRIT J NUTR, V92, P347, DOI 10.1079/BJN20041213
   Vargas ML, 2011, METABOLISM, V60, P1711, DOI 10.1016/j.metabol.2011.04.007
   Wang H, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-42
   Wang YR, 2017, J DIABETES RES, V2017, DOI 10.1155/2017/3510275
   Wöbke TK, 2014, FRONT PHYSIOL, V5, DOI 10.3389/fphys.2014.00244
   Yahagi K, 2017, ARTERIOSCL THROM VAS, V37, P191, DOI 10.1161/ATVBAHA.116.306256
   Zhang XG, 2014, EUR REV MED PHARMACO, V18, P3593
   Zhang Y, 2018, BJOG, V125, P784, DOI 10.1111/1471-0528.15060
   Zhao GX, 2007, AM J CLIN NUTR, V85, P385, DOI 10.1093/ajcn/85.2.385
   Zhao GX, 2005, BIOCHEM BIOPH RES CO, V336, P909, DOI 10.1016/j.bbrc.2005.08.204
   Zheng JS, 2016, MOL NUTR FOOD RES, V60, P2176, DOI 10.1002/mnfr.201600230
NR 59
TC 20
Z9 20
U1 1
U2 9
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD AUG 28
PY 2019
VL 122
IS 4
BP 423
EP 430
AR PII S0007114519001132
DI 10.1017/S0007114519001132
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA IW9PS
UT WOS:000485326300006
PM 31309919
OA Bronze
DA 2025-06-11
ER

PT J
AU Simao, ANC
   Lehmann, MF
   Alfieri, DF
   Meloni, MZ
   Flauzino, T
   Scavuzzi, BM
   de Oliveira, SR
   Lozovoy, MAB
   Dichi, I
   Reiche, EMV
AF Colado Simao, Andrea Name
   Lehmann, Marcio Francisco
   Alfieri, Daniela Frizon
   Meloni, Milena Zardetto
   Flauzino, Tamires
   Scavuzzi, Bruna Miglioranza
   de Oliveira, Sayonara Rangel
   Batisti Lozovoy, Marcell Alysson
   Dichi, Isaias
   Vissoci Reiche, Edna Maria
TI Metabolic syndrome increases oxidative stress but does not influence
   disability and short-time outcome in acute ischemic stroke patients
SO METABOLIC BRAIN DISEASE
LA English
DT Article
DE Stroke; Oxidative stress; Metabolic syndrome; Disability; Modified
   Rankin scale
ID ANTIOXIDANT CAPACITY; DENSITY-LIPOPROTEIN; INSULIN-RESISTANCE;
   URIC-ACID; RISK; HEART; ALBUMIN; MARKERS; BLOOD; INFLAMMATION
AB Oxidative stress has been implicated in the pathophysiology of cardiovascular disease and MetS and it may be one of molecular mechanisms involved in stroke. The aims of the present study were to verify differences in oxidative stress markers in acute ischemic stroke patients with and without MetS and to verify whether MetS influences disability and short time outcome of the patients. 148 patients with acute ischemic stroke were divided in two groups: with MetS (n = 92) and without MetS (n = 56). The modified Rankin Scale (mRS) was used for measuring the functional disability after 3-month follow-up. The study assessed the metabolic profile and oxidative stress markers. Stroke patients with MetS had higher levels of lipid hydroperoxides (p < 0.0001) and advanced oxidation protein products (AOPP, p = 0.0302) than those without MetS. Hydroperoxides were directly and independently associated with MetS (OR: 1.000, 95 % IC = 1.000-1.000, p = 0.005). Linear regression demonstrated that AOPP levels (R-2 = 0.281, p < 0.0001) and oxidative stress index (OSI, R-2 = 0.223, p < 0.0001) were directly associated with triglycerides levels and hydroperoxides levels was also directly associated with glucose levels (R-2 = 0.080, p = 0.013. The mRS and short-come outcome did not differ after 3 months in both groups. In conclusion, an increase in oxidative stress markers was shown in acute ischemic stroke patients with MetS and this elevation seems to be involved mainly with changes in lipid profile, but the presence of MetS did not influence short-time disability and survival of the acute ischemic stroke patients.
C1 [Colado Simao, Andrea Name; Alfieri, Daniela Frizon; Meloni, Milena Zardetto; Flauzino, Tamires; Scavuzzi, Bruna Miglioranza; Batisti Lozovoy, Marcell Alysson; Vissoci Reiche, Edna Maria] Univ Estadual Londrina, Dept Clin Pathol Clin Anal & Toxicol, BR-86038440 Londrina, Parana, Brazil.
   [Lehmann, Marcio Francisco] Univ Londrina, Dept Neurol Surg, Londrina, Parana, Brazil.
   [de Oliveira, Sayonara Rangel] Univ North Parana UNOPAR, Dept Clin Anal, Londrina, Parana, Brazil.
   [Dichi, Isaias] Univ Londrina, Dept Internal Med, Londrina, Parana, Brazil.
C3 Universidade Estadual de Londrina; University Norte Parana
RP Simao, ANC (corresponding author), Univ Estadual Londrina, Dept Clin Pathol Clin Anal & Toxicol, Robert Koch Ave 60, BR-86038440 Londrina, Parana, Brazil.
EM deianame@yahoo.com.br
RI Reiche, EDNa/AAD-4186-2020; Scavuzzi, Bruna/AAK-7916-2020; Alfieri,
   Daniela/LSI-6403-2024; Simão, Andrea/AAM-4892-2021; Lozovoy,
   Marcell/AAM-4897-2021; Reiche, Edna Maria Vissoci/C-4102-2013
OI Alfieri, Daniela/0000-0002-0217-9329; Miglioranza Scavuzzi,
   Bruna/0000-0001-9609-001X; Reiche, Edna Maria
   Vissoci/0000-0001-6507-2839
CR ADAMS HP, 1993, STROKE, V24, P35, DOI 10.1161/01.STR.24.1.35
   Alexandrova ML, 2005, FREE RADICAL BIO MED, V39, P297, DOI 10.1016/j.freeradbiomed.2005.04.017
   Babu MS, 2013, NUTRITION, V29, P872, DOI 10.1016/j.nut.2012.12.015
   Banks JL, 2007, STROKE, V38, P1091, DOI 10.1161/01.STR.0000258355.23810.c6
   Berg E. van den, 2007, Neurology, V69, P979, DOI 10.1212/01.wnl.0000271381.30143.75
   BONITA R, 1988, STROKE, V19, P1497, DOI 10.1161/01.STR.19.12.1497
   Çakatay U, 2005, DIABETES METAB, V31, P551, DOI 10.1016/S1262-3636(07)70230-6
   Casado MF, 2007, FOOD CHEM TOXICOL, V45, P945, DOI 10.1016/j.fct.2006.12.001
   Chakraborty B, 2013, J STROKE CEREBROVASC, V22, pE159, DOI 10.1016/j.jstrokecerebrovasdis.2012.10.013
   Chang CY, 1988, FREE RADICAL RES, V28, P15
   Cherubini A, 2005, FREE RADICAL BIO MED, V39, P841, DOI 10.1016/j.freeradbiomed.2005.06.025
   Chiquete E, 2013, CEREBROVASC DIS, V35, P168, DOI 10.1159/000346603
   Simao ANC, 2008, NUTRITION, V24, P675, DOI 10.1016/j.nut.2008.03.021
   Dichi I, 2012, EXPERT OPIN THER TAR, V16, P147, DOI 10.1517/14728222.2012.648924
   Domínguez C, 2010, STROKE, V41, P653, DOI 10.1161/STROKEAHA.109.571935
   El Kossi MMH, 2000, STROKE, V31, P1889, DOI 10.1161/01.STR.31.8.1889
   FLECHA BG, 1991, FREE RADICAL BIO MED, V10, P93
   Fujita K, 2006, CIRC J, V70, P1437, DOI 10.1253/circj.70.1437
   Gariballa SE, 2002, QJM-INT J MED, V95, P685, DOI 10.1093/qjmed/95.10.685
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Haffner SM, 1997, DIABETES CARE, V20, P1087, DOI 10.2337/diacare.20.7.1087
   Hanchaiphiboolkul S, 2013, J STROKE CEREBROVASC, V22, pE264, DOI 10.1016/j.jstrokecerebrovasdis.2012.05.013
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Kalmijn S, 2000, ARTERIOSCL THROM VAS, V20, P2255, DOI 10.1161/01.ATV.20.10.2255
   Katsuki A, 2004, DIABETES CARE, V27, P631, DOI 10.2337/diacare.27.2.631
   Kondo T, 2009, J ATHEROSCLER THROMB, V16, P532, DOI 10.5551/jat.1255
   Lee KU, 2001, DIABETES RES CLIN PR, V54, pS29, DOI 10.1016/S0168-8227(01)00332-1
   Manzanero S, 2013, NEUROCHEM INT, V62, P712, DOI 10.1016/j.neuint.2012.11.009
   Miller M, 2011, CIRCULATION, V123, P2292, DOI 10.1161/CIR.0b013e3182160726
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Navab M, 2000, J LIPID RES, V41, P1495
   Oh MS, 2011, BMC NEUROL, V11, DOI 10.1186/1471-2377-11-138
   Osborn MF, 2014, J STROKE CEREBROVASC, V23, P1477, DOI 10.1016/j.jstrokecerebrovasdis.2013.12.017
   Parreira JD, 2015, METAB BRAIN DIS, V30, P159, DOI 10.1007/s11011-014-9584-6
   Pinheiro CHJ, 2014, ROLE OXIDATIVE STRES, P137
   Quinn TJ, 2009, STROKE, V40, P762, DOI 10.1161/STROKEAHA.108.522516
   Repetto M, 1996, CLIN CHIM ACTA, V255, P107, DOI 10.1016/0009-8981(96)06394-2
   REZNICK AZ, 1994, METHOD ENZYMOL, V233, P357
   Sebeková K, 2006, MOL NUTR FOOD RES, V50, P858, DOI 10.1002/mnfr.200500170
   Simao ANC, 2014, OXIDATIVE STRESS CHR, P246
   Tuttolomondo A, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-28
   Uchino K, 2001, STROKE, V32, P909, DOI 10.1161/01.STR.32.4.909
   Urakawa H, 2003, J CLIN ENDOCR METAB, V88, P4673, DOI 10.1210/jc.2003-030202
   Uyttenboogaart M, 2005, STROKE, V36, P1984, DOI 10.1161/01.STR.0000177872.87960.61
   Weaver CS, 2004, STROKE, V35, P1216, DOI 10.1161/01.STR.0000125010.70652.93
   Witko-Sarsat V, 1998, J IMMUNOL, V161, P2524
   Woodruff TM, 2011, MOL NEURODEGENER, V6, DOI 10.1186/1750-1326-6-11
   Yaffe K, 2004, JAMA-J AM MED ASSOC, V292, P2237, DOI 10.1001/jama.292.18.2237
   Zurawska-Plaksej E, 2014, J ENDOCRINOL INVEST, V37, P819, DOI 10.1007/s40618-014-0111-8
NR 49
TC 14
Z9 14
U1 0
U2 4
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0885-7490
EI 1573-7365
J9 METAB BRAIN DIS
JI Metab. Brain Dis.
PD DEC
PY 2015
VL 30
IS 6
BP 1409
EP 1416
DI 10.1007/s11011-015-9720-y
PG 8
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA CW6DB
UT WOS:000365086600011
PM 26342606
DA 2025-06-11
ER

PT J
AU Koch, DA
   Scott, AJ
AF Koch, D. A.
   Scott, A. J.
TI Weight gain and lipid-glucose profiles among patients taking
   antipsychotic medications: comparisons for prescriptions administered
   using algorithms versus usual care
SO JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING
LA English
DT Article
DE algorithm; antipsychotic; criteria; evidence-based practice; metabolic;
   prescribing
AB The purpose of this study was to determine if treatment strategy had a significant effect on the occurrence of physiological changes consistent with metabolic syndrome and/or type 2 diabetes in patients using atypical antipsychotic medications. The four variables assessed were: weight gain, fasting blood sugar, triglycerides and cholesterol. The two strategies compared were (1) evidence-based practice, derived from the Texas Medication Algorithm Project, and (2) practitioner preference. A retrospective chart review was performed on patients diagnosed with a chronic psychiatric disorder being treated with atypical antipsychotics. The dates of the reviewed records were from 1 January 2008 to 31 December 2008. The sample of patients totaled 113. Statistical analysis included logistic regression for each of the four variables assessed. The use of evidence-based practice guidelines was found to have strong positive effects on two of the four variables assessed. Further studies need to be conducted to include medications being taken to lower lipids and blood sugar. Overall, the use of evidence-based practice guidelines has a positive effect on weight, triglycerides and cholesterol. It is important that patients be closely monitored and changes made in a timely manner to minimize adverse effects of atypical antipsychotics.
C1 [Koch, D. A.] Univ Arkansas Ft Smith, Ft Smith, AR 72913 USA.
   [Scott, A. J.] Univ Arkansas, Fayetteville, AR 72701 USA.
C3 University of Arkansas System; University of Arkansas Fort Smith;
   University of Arkansas System; University of Arkansas Fayetteville
RP Koch, DA (corresponding author), Univ Arkansas Ft Smith, 5210 Grand Ft Smith Ave, Ft Smith, AR 72913 USA.
EM arlouko@cox.net
CR Baker R.A., 2009, ATYPICAL ANTIPSYCHOT
   Busko M., 2007, MONITORING METABOLIC
   Gibson A.P., 2008, CURRENT PSYCHIAT, V7, P40
   Jennex A., 2008, MONITORING MANAGEMEN
   KASHNER TM, 1999, J MENT HEALTH POLICY, V2, P111
   Lieberman Joseph A 3rd, 2004, Prim Care Companion J Clin Psychiatry, V6, P8
   National Association of State Mental Health Program Directors, 1997, ALG MED TREATM PEOPL
   PERITOGIANNIS V, 2006, ANN GEN PSYCHIAT S1, V5, pS269, DOI DOI 10.1186/1744-859X-5-S1-S269
   Sneed KB, 2003, J AM BOARD FAM PRACT, V16, P251, DOI 10.3122/jabfm.16.3.251
   The Commonwealth Fund, 2006, TEX MED ALG PROJ
   Trivedi MH, 2004, ARCH GEN PSYCHIAT, V61, P669, DOI 10.1001/archpsyc.61.7.669
   Tschoner A, 2007, INT J CLIN PRACT, V61, P1356, DOI 10.1111/j.1742-1241.2007.01416.x
NR 12
TC 4
Z9 7
U1 0
U2 4
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1351-0126
J9 J PSYCHIATR MENT HLT
JI J. Psychiatr. Ment. Health Nurs.
PD JUN
PY 2012
VL 19
IS 5
BP 389
EP 394
DI 10.1111/j.1365-2850.2011.01781.x
PG 6
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 934KC
UT WOS:000303442000003
PM 22070226
DA 2025-06-11
ER

PT J
AU Hulsmans, M
   Holvoet, P
AF Hulsmans, Maarten
   Holvoet, Paul
TI The vicious circle between oxidative stress and inflammation in
   atherosclerosis
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Review
DE atherosclerosis; metabolic syndrome; diabetes; inflammation; oxidative
   stress; adipose tissue; vascular tissue; oxidized LDL
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; ADIPOSE-TISSUE
   INFLAMMATION; SMOOTH-MUSCLE-CELLS; C-REACTIVE PROTEIN; METABOLIC
   SYNDROME; OXIDIZED LDL; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   PHOSPHOLIPASE A(2)
AB Introduction
   Overview of molecular mechanisms explaining the association of inflammation and oxidative stress in the vessel wall
   Regulatory mechanisms of interactions between oxidative stress and inflammation
   Overview of molecular mechanisms explaining the association of inflammation and oxidative stress in adipose tissues
   Conclusions
   The initial event in atherogenesis is the increased transcytosis of low density lipoprotein, and its subsequent deposition, retention and modification in the subendothelium. It is followed by the infiltration of activated inflammatory cells from the coronary circulation into the arterial wall. There they secrete reactive oxygen species (ROS) and produce oxidized lipoproteins capable of inducing endothelial cell apoptosis, and thereby plaque erosion. Activated T lymphocytes, macrophages and mast cells, accumulate in the eroded plaque where they secrete a variety of proteases capable of inducing degradation of extracellular proteins, thereby rendering the plaques more prone to rupture. This review summarizes the recent advancements in the understanding of the roles of ROS and oxidized lipoproteins in the activation of inflammatory cells and inducing signalling pathways related to cell death and apoptosis. In addition, it presents evidence that this vicious circle between oxidative stress and inflammation does not only occur in the diseased arterial wall, but also in adipose tissues. There, oxidative stress and inflammation impair adipocyte maturation resulting in defective insulin action and adipocytokine signalling. The latter is associated with increased infiltration of inflammatory cells, loss of anti-oxidant protection and cell death in the arterial wall.
C1 [Hulsmans, Maarten; Holvoet, Paul] Katholieke Univ Leuven, Dept Cardiovasc Dis, Atherosclerosis & Metab Unit, B-3000 Louvain, Belgium.
C3 KU Leuven
RP Holvoet, P (corresponding author), Katholieke Univ Leuven, Dept Cardiovasc Dis, Atherosclerosis & Metab Unit, Herestr 49,O&N1,PB 705, B-3000 Louvain, Belgium.
EM paul.holvoet@med.kuleuven.be
RI HOLVOET, PAUL/T-8434-2017; Hulsmans, Maarten/AAI-9547-2020
OI Holvoet, Paul/0000-0001-9201-0772; Hulsmans, Maarten/0000-0003-1009-658X
FU Interuniversitaire Attractiepolen Programma of the Belgian Federal
   Government [P06/30]; Bijzonder Onderzoeksfonds of the Katholieke
   Universiteit Leuven [OT/06/56]; Fonds voor Wetenschappelijk
   Onderzoek-Vlaanderen (Vascular Biology Network)
FX Funding was provided by the Interuniversitaire Attractiepolen Programma
   of the Belgian Federal Government (P06/30), the Bijzonder
   Onderzoeksfonds of the Katholieke Universiteit Leuven (OT/06/56) and by
   the Fonds voor Wetenschappelijk Onderzoek-Vlaanderen (Vascular Biology
   Network).
CR Arkan MC, 2005, NAT MED, V11, P191, DOI 10.1038/nm1185
   Augé N, 2004, CIRCULATION, V110, P571, DOI 10.1161/01.CIR.0000136995.83451.1D
   Bastard JP, 2006, EUR CYTOKINE NETW, V17, P4
   Bouhlel MA, 2007, CELL METAB, V6, P137, DOI 10.1016/j.cmet.2007.06.010
   Boyanovsky B, 2009, ARTERIOSCL THROM VAS, V29, P532, DOI 10.1161/ATVBAHA.108.183038
   Cho CH, 2007, CIRC RES, V100, pE47, DOI 10.1161/01.RES.0000259564.92792.93
   Cinti S, 2005, J LIPID RES, V46, P2347, DOI 10.1194/jlr.M500294-JLR200
   Cipolletta C, 2005, DIABETES, V54, P2779, DOI 10.2337/diabetes.54.9.2779
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Conen D, 2009, CIRCULATION, V120, P1041, DOI 10.1161/CIRCULATIONAHA.109.863092
   De Keyzer D, 2009, ARTERIOSCL THROM VAS, V29, P2041, DOI 10.1161/ATVBAHA.109.196592
   de Luca C, 2008, FEBS LETT, V582, P97, DOI 10.1016/j.febslet.2007.11.057
   Desjardins F, 2008, EUR HEART J, V29, P128, DOI 10.1093/eurheartj/ehm540
   Duncan BB, 2003, DIABETES, V52, P1799, DOI 10.2337/diabetes.52.7.1799
   Feuerer M, 2009, NAT MED, V15, P930, DOI 10.1038/nm.2002
   Fonseca V, 2004, ENDOCR REV, V25, P153, DOI 10.1210/er.2002-0034
   Ford ES, 2004, ATHEROSCLEROSIS, V173, P309, DOI 10.1016/j.atherosclerosis.2003.12.022
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Girman CJ, 2004, AM J CARDIOL, V93, P136, DOI 10.1016/j.amjcard.2003.09.028
   Goodpaster BH, 2005, ARCH INTERN MED, V165, P777, DOI 10.1001/archinte.165.7.777
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Hakala JK, 2001, ARTERIOSCL THROM VAS, V21, P1053, DOI 10.1161/01.ATV.21.6.1053
   Heilbronn LK, 2008, CURR PHARM DESIGN, V14, P1225, DOI 10.2174/138161208784246153
   Holvoet P, 2004, DIABETES, V53, P1068, DOI 10.2337/diabetes.53.4.1068
   Holvoet P, 1998, ARTERIOSCL THROM VAS, V18, P415, DOI 10.1161/01.ATV.18.3.415
   Holvoet P, 2008, JAMA-J AM MED ASSOC, V299, P2287, DOI 10.1001/jama.299.19.2287
   Holvoet P, 2006, ARTERIOSCL THROM VAS, V26, P1558, DOI 10.1161/01.ATV.0000226553.01555.02
   Hunt KJ, 2004, CIRCULATION, V110, P1251, DOI 10.1161/01.CIR.0000140762.04598.F9
   Isomaa B, 2001, DIABETOLOGIA, V44, P1148, DOI 10.1007/s001250100615
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   Karabina SA, 2006, FASEB J, V20, P2547, DOI 10.1096/fj.06-6018fje
   Kintscher U, 2008, ARTERIOSCL THROM VAS, V28, P1304, DOI 10.1161/ATVBAHA.108.165100
   Kolmakova A, 2004, ARTERIOSCL THROM VAS, V24, P264, DOI 10.1161/01.ATV.0000112036.72200.ac
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lempiäinen P, 1999, CIRCULATION, V100, P123, DOI 10.1161/01.CIR.100.2.123
   Liu J, 2009, CIRC RES, V105, P295, DOI 10.1161/CIRCRESAHA.109.194613
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Masella R, 2006, FEBS LETT, V580, P2421, DOI 10.1016/j.febslet.2006.03.068
   McLaughlin T, 2001, METABOLISM, V50, P795, DOI 10.1053/meta.2001.24210
   Merkel M, 2002, J BIOL CHEM, V277, P7405, DOI 10.1074/jbc.M107914200
   MERRILL AH, 1990, BIOCHIM BIOPHYS ACTA, V1044, P1, DOI 10.1016/0005-2760(90)90211-F
   Mertens A, 2003, CIRCULATION, V107, P1640, DOI 10.1161/01.CIR.0000056523.08033.9F
   Mertens A, 2001, FASEB J, V15, P2073, DOI 10.1096/fj.01-0273rev
   Moura R, 2008, CIRC RES, V103, P1181, DOI 10.1161/CIRCRESAHA.108.185645
   Mukhopadhyay S, 2009, ADV EXP MED BIOL, V653, P1, DOI 10.1109/TENCON.2009.5396176
   Nishimura S, 2007, DIABETES, V56, P1517, DOI 10.2337/db06-1749
   Nishimura S, 2009, NAT MED, V15, P914, DOI 10.1038/nm.1964
   Onat A, 2002, ATHEROSCLEROSIS, V165, P285, DOI 10.1016/S0021-9150(02)00236-8
   Ouedraogo R, 2006, DIABETES, V55, P1840, DOI 10.2337/db05-1174
   Park K, 2009, DIABETES CARE, V32, P1302, DOI 10.2337/dc09-0259
   Pasarica M, 2009, DIABETES, V58, P718, DOI 10.2337/db08-1098
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Pruzanski W, 2005, BBA-MOL CELL BIOL L, V1736, P38, DOI 10.1016/j.bbalip.2005.07.005
   Reilly MP, 2005, CIRCULATION, V111, P932, DOI 10.1161/01.CIR.0000155620.10387.43
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   Ronald JA, 2009, CIRCULATION, V120, P592, DOI 10.1161/CIRCULATIONAHA.108.813998
   Sakamoto Y, 2005, ATHEROSCLEROSIS, V183, P85, DOI 10.1016/j.atherosclerosis.2005.02.032
   Sato H, 2008, J BIOL CHEM, V283, P33483, DOI 10.1074/jbc.M804628200
   Schwab JM, 2007, NATURE, V447, P869, DOI 10.1038/nature05877
   Segers D, 2007, CIRCULATION, V115, P609, DOI 10.1161/CIRCULATIONAHA.106.636415
   Simionescu M, 2007, ARTERIOSCL THROM VAS, V27, P266, DOI 10.1161/01.ATV.0000253884.13901.e4
   Son BK, 2008, ENDOCRINOLOGY, V149, P1646, DOI 10.1210/en.2007-1021
   Spite M, 2009, BRIT J PHARMACOL, V158, P1062, DOI 10.1111/j.1476-5381.2009.00234.x
   Stengel D, 1998, ARTERIOSCL THROM VAS, V18, P1172, DOI 10.1161/01.ATV.18.7.1172
   Stern MP, 2005, ATHEROSCLEROSIS SUPP, V6, P3, DOI 10.1016/j.atherosclerosissup.2005.02.002
   Subbanagounder G, 2000, ARTERIOSCL THROM VAS, V20, P2248, DOI 10.1161/01.ATV.20.10.2248
   Subbanagounder G, 2002, J BIOL CHEM, V277, P7271, DOI 10.1074/jbc.M107602200
   Uysal KT, 1997, NATURE, V389, P610, DOI 10.1038/39335
   Verreth W, 2007, BRIT J PHARMACOL, V151, P347, DOI 10.1038/sj.bjp.0707231
   Verreth W, 2004, CIRCULATION, V110, P3259, DOI 10.1161/01.CIR.0000147614.85888.7A
   Vickers KC, 2009, J LIPID RES, V50, P1735, DOI 10.1194/jlr.M800342-JLR200
   Virella G, 2008, ATHEROSCLEROSIS, V200, P239, DOI 10.1016/j.atherosclerosis.2008.03.025
   Walczak R, 2004, J BIOL CHEM, V279, P9905, DOI 10.1074/jbc.M310587200
   Weisberg SP, 2006, J CLIN INVEST, V116, P115, DOI 10.1172/JCI24335
   Wigren M, 2009, CIRC RES, V104, pE62, DOI 10.1161/CIRCRESAHA.109.196667
NR 75
TC 213
Z9 239
U1 0
U2 29
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1582-1838
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD JAN-FEB
PY 2010
VL 14
IS 1-2
BP 70
EP 78
DI 10.1111/j.1582-4934.2009.00978.x
PG 9
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA 569YV
UT WOS:000275639700006
PM 19968738
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU de la Torre-luque, A
   Pemau, A
   Galvez-Merlin, A
   Garcia-Ramos, A
AF de la Torre-luque, Alejandro
   Pemau, Andres
   Galvez-Merlin, Alejandra
   Garcia-Ramos, Adriana
TI Immunometabolic alterations in older adults with heightened depressive
   symptom trajectories: a network approach
SO AGING & MENTAL HEALTH
LA English
DT Article
DE Depression; late life; inflammation; metabolic markers; loneliness;
   network analysis
ID LATE-LIFE DEPRESSION; ASSOCIATION; DISEASE; CONNECTIVITY; HYPERTENSION;
   METAANALYSIS; LONELINESS; MORTALITY; AGE
AB Objective: To analyse the patterns of relationships between depressive symptoms and immunometabolic markers across longitudinal depression status in older people. Methods: A sample of 3349 older adults (55.21% women; initial age: m = 58.44, sd = 5.21) from the English Longitudinal Study of Ageing was used. Participants were classified according to their longitudinal depression status: minimal depressive symptoms (n = 2736), depressive episode onset (n = 481), or chronic depression (n = 132). Network analysis was used to study the relationships between depression symptoms (CES-D 8 items), inflammatory (white blood cell, C-reactive protein, fibrinogen) and metabolic biomarkers (metabolic syndrome markers). Results: Network structure remained invariant across groups. The minimal symptom group had higher overall strength than both clinical groups (p < .01). Moreover, significant relationships between symptoms and markers were observed across group-specific networks. C-reactive protein and effort symptom were positively connected in the minimal symptom group but not in the other groups. Loneliness and diastolic blood pressure were positively associated only in the chronic depression group. Finally, metabolic markers were identified as central nodes in the clinical status networks. Conclusion: The network analysis constitutes a useful approach to disentangle pathophysiological relationships that may maintain mental disorders in old age.
C1 [de la Torre-luque, Alejandro; Garcia-Ramos, Adriana] Univ Complutense Madrid, Dept Legal Med Psychiat & Pathol, Madrid, Spain.
   [de la Torre-luque, Alejandro] Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain.
   [Pemau, Andres; Galvez-Merlin, Alejandra] Univ Complutense Madrid, Fac Psychol, Madrid, Spain.
C3 Complutense University of Madrid; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERSAM; Complutense University of Madrid
RP Pemau, A (corresponding author), Univ Complutense Madrid, Fac Psychol, Madrid, Spain.
EM apemau@ucm.es
RI de la Torre-Luque, Alejandro/AAJ-3508-2020; Pemau, Andrés/AHB-4203-2022;
   Pemau, Andres/HNJ-3824-2023
OI Garcia-Ramos, Adriana/0000-0002-3246-9917; Pemau,
   Andres/0000-0002-5835-507X
FU U.S. National Institute of Aging; National Centre for Social Research;
   University College London (UCL); Instituto de Salud Carlos III-FIS
   [PI20/00229]; European Regional Development Fund (ERDF) "A Way to Build
   Europe"
FX The ELSA study is supported by the U.S. National Institute of Aging, the
   National Centre for Social Research, the University College London (UCL)
   and the Institute for Fiscal Studies. The authors gratefully acknowledge
   the UK Data Service and UCL who provided data for this paper. This study
   was supported by the Instituto de Salud Carlos III-FIS research grant
   PI20/00229, co-funded by the European Regional Development Fund (ERDF)
   "A Way to Build Europe".
CR Airaksinen J, 2020, J AFFECT DISORDERS, V266, P230, DOI 10.1016/j.jad.2020.01.170
   Almeida OP, 2007, AM J GERIAT PSYCHIAT, V15, P506, DOI 10.1097/01.JGP.0000246869.49892.77
   Banks J., 2014, ELSA WAVE 6 DYNAMICS
   Berlim MT, 2021, PSYCHOL MED, V51, P2399, DOI 10.1017/S0033291720001002
   Blanken TF, 2019, PSYCHOTHER PSYCHOSOM, V88, P52, DOI 10.1159/000495045
   Bornas X., 2017, NEUROPSYCHIATRY-LOND, V7, P466, DOI DOI 10.4172/NEUROPSYCHIATRY.1000238
   Borsboom D, 2013, ANNU REV CLIN PSYCHO, V9, P91, DOI 10.1146/annurev-clinpsy-050212-185608
   Bos FM, 2018, SOC PSYCH PSYCH EPID, V53, P617, DOI 10.1007/s00127-018-1506-1
   Cacioppo JT, 2015, ANNU REV PSYCHOL, V66, P733, DOI 10.1146/annurev-psych-010814-015240
   Chojnacki C, 2020, NUTRIENTS, V12, DOI 10.3390/nu12103183
   Costemale-Lacoste JF, 2020, J AFFECT DISORDERS, V264, P513, DOI 10.1016/j.jad.2019.11.084
   Cukic M, 2020, INT J METH PSYCH RES, V29, DOI 10.1002/mpr.1816
   Das J, 2018, NEUROSCI BIOBEHAV R, V90, P104, DOI 10.1016/j.neubiorev.2018.04.005
   de la Torre-Luque A, 2019, ACTA PSYCHIAT SCAND, V140, P541, DOI 10.1111/acps.13107
   de la Torre-Luque A, 2019, PSYCHONEUROENDOCRINO, V110, DOI 10.1016/j.psyneuen.2019.104443
   De Vos AC, 2018, PHYSIOL BEHAV, V194, P474, DOI 10.1016/j.physbeh.2018.06.038
   Epskamp S, 2018, PSYCHOL METHODS, V23, P617, DOI 10.1037/met0000167
   Epskamp S, 2018, BEHAV RES METHODS, V50, P195, DOI 10.3758/s13428-017-0862-1
   Forouzanfar MH, 2017, JAMA-J AM MED ASSOC, V317, P165, DOI 10.1001/jama.2016.19043
   Fried EI, 2020, PSYCHOL MED, V50, P2682, DOI 10.1017/S0033291719002770
   Gallo JJ, 2016, J GEN INTERN MED, V31, P380, DOI 10.1007/s11606-015-3524-y
   Groen RN, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-54801-y
   Hakulinen C, 2020, SOC PSYCH PSYCH EPID, V55, P1273, DOI 10.1007/s00127-020-01843-7
   Han W., 2017, MULTIPLE IMPUTATION, P894
   Hawkley LC, 2003, BRAIN BEHAV IMMUN, V17, pS98
   Hawkley Louise C, 2010, Ann Behav Med, V40, P218, DOI 10.1007/s12160-010-9210-8
   Jokela M, 2016, JAMA PSYCHIAT, V73, P87, DOI 10.1001/jamapsychiatry.2015.1977
   JORM AF, 1994, PSYCHOL MED, V24, P145, DOI 10.1017/S003329170002691X
   Karim J, 2015, CURR PSYCHOL, V34, P681, DOI 10.1007/s12144-014-9281-y
   Kim JM, 2018, PSYCHONEUROENDOCRINO, V90, P85, DOI 10.1016/j.psyneuen.2018.02.006
   Lamers F, 2020, BRAIN BEHAV IMMUN, V88, P174, DOI 10.1016/j.bbi.2020.04.002
   Laursen TM, 2016, J AFFECT DISORDERS, V193, P203, DOI 10.1016/j.jad.2015.12.067
   Lim GY, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-21243-x
   Liu QQ, 2020, J PSYCHIATR RES, V126, P134, DOI 10.1016/j.jpsychires.2019.08.002
   Martínez-Cengotitabengoa M, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17122022
   Mattson MP, 2004, AGEING RES REV, V3, P445, DOI 10.1016/j.arr.2004.08.001
   McElroy E, 2019, ECLINICALMEDICINE, V8, P29, DOI 10.1016/j.eclinm.2019.02.009
   McNally RJ, 2016, BEHAV RES THER, V86, P95, DOI 10.1016/j.brat.2016.06.006
   Milaneschi Y, 2020, BIOL PSYCHIAT, V88, P369, DOI 10.1016/j.biopsych.2020.01.014
   Momtaz YA, 2012, J AGING HEALTH, V24, P696, DOI 10.1177/0898264311431305
   Moriarity DP, 2021, BRAIN BEHAV IMMUN, V93, P35, DOI 10.1016/j.bbi.2020.12.005
   Moulton CD, 2015, LANCET DIABETES ENDO, V3, P461, DOI 10.1016/S2213-8587(15)00134-5
   Osimo EF, 2020, BRAIN BEHAV IMMUN, V87, P901, DOI 10.1016/j.bbi.2020.02.010
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Penninx BWJH, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-129
   R Core Team, 2017, R: A Language and Environment for Statistical Computing
   Ram N, 2009, INT J BEHAV DEV, V33, P565, DOI 10.1177/0165025409343765
   Repousi N, 2018, J AFFECT DISORDERS, V237, P56, DOI 10.1016/j.jad.2018.04.102
   Santoro A, 2021, AGEING RES REV, V71, DOI 10.1016/j.arr.2021.101422
   Segeda V, 2017, J PSYCHIATR RES, V91, P164, DOI 10.1016/j.jpsychires.2017.04.011
   Shiovitz-Ezra S, 2019, AGING MENT HEALTH, V23, P1358, DOI 10.1080/13607863.2018.1488942
   Smith KJ, 2018, EXP GERONTOL, V102, P109, DOI 10.1016/j.exger.2017.12.005
   Steptoe A, 2013, INT J EPIDEMIOL, V42, P1640, DOI 10.1093/ije/dys168
   Sterne Jonathan A C, 2009, BMJ, V338, pb2393, DOI 10.1136/bmj.b2393
   van Borkulo C, 2015, JAMA PSYCHIAT, V72, P1219, DOI 10.1001/jamapsychiatry.2015.2079
   van Eeden WA, 2020, TRANSL PSYCHIAT, V10, DOI 10.1038/s41398-020-00920-4
   Vogelzangs N, 2014, BRAIN BEHAV IMMUN, V41, P109, DOI 10.1016/j.bbi.2014.05.004
   Williams DR, 2019, MULTIVAR BEHAV RES, V54, P719, DOI 10.1080/00273171.2019.1575716
   Xu HB, 2012, INT J NEUROPSYCHOPH, V15, P1413, DOI 10.1017/S1461145712000302
   Yang CH, 2019, J AFFECT DISORDERS, V257, P640, DOI 10.1016/j.jad.2019.07.045
   Ylli A, 2016, PSYCHIAT RES, V241, P236, DOI 10.1016/j.psychres.2016.04.096
NR 61
TC 0
Z9 0
U1 4
U2 20
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1360-7863
EI 1364-6915
J9 AGING MENT HEALTH
JI Aging Ment. Health
PD NOV 2
PY 2023
VL 27
IS 11
BP 2229
EP 2237
DI 10.1080/13607863.2023.2227114
EA JUN 2023
PG 9
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA FP1V1
UT WOS:001022982300001
PM 37401624
DA 2025-06-11
ER

PT J
AU Dixon, JB
   Schachter, LM
   O'Brien, PE
AF Dixon, JB
   Schachter, LM
   O'Brien, PE
TI Polysomnography before and after weight loss in obese patients with
   severe sleep apnea
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
DE sleep; weight loss; gastric; banding; comorbidity; metabolic syndrome;
   quality of life
ID QUALITY-OF-LIFE; GASTRIC BYPASS; HEALTH; SURGERY
AB OBJECTIVE: While obstructive sleep apnea (OSA) is strongly related to obesity, few studies have examined polysomnographic (PSG) changes with major weight loss. We examined the effect of weight loss following laparoscopic adjustable gastric banding (LAGB) on the PSG changes in patients with severe OSA. In addition, we studied daytime sleepiness, the metabolic syndrome and quality of life (QOL).
   METHODS: A prospective study was conducted of 25 severely obese patients (17 men, eight women) with paired diagnostic PSG, biochemical and questionnaire studies, the first prior to LAGB and the second at least 1y later. Subjects with a baseline apnea-hypopnea index (AHI) > 25/h were included.
   RESULTS: Subject baseline age was 44.7 y, weight 154 kg and body mass index 52.7 kg/m(2). The second PSG study was conducted 17.7 +/- 10 (range 12-42) months after surgery and mean percentage of excess loss and weight loss were 50.1 +/- 15% (range 24-80%) and 44.9 +/- 22 kg ( range 18-103 kg), respectively. There was a significant fall in AHI from 61.6 +/- 34 to 13.4 +/- 13, improved sleep architecture with increased REM and stage III and IV sleep, daytime sleepiness, as measured by Epworth Sleepiness Scale, of 13 +/- 7.0 to 3.8 +/- 3.0, and fewer patients requiring nasal continuous positive airways pressure (CPAP). There were also major improvements in the metabolic syndrome, QOL, body image and fewer symptoms of depression (P < 0.05 for all).
   CONCLUSION: Weight loss provides major improvement or resolution of OSA and CPAP requirements. It also reduces daytime sleepiness, and improves the metabolic syndrome and QOL. LAGB placement should be considered a broadly effective therapy for sleep apnea in the severely obese patient.
C1 Monash Univ, Alfred Hosp, Ctr Obes Res & Educ, Melbourne, Vic 3004, Australia.
C3 Florey Institute of Neuroscience & Mental Health; Howard Florey
   Institute Affiliates; Monash University
RP Monash Univ, Alfred Hosp, Ctr Obes Res & Educ, Melbourne, Vic 3004, Australia.
EM john.dixon@med.monash.edu.au
RI Dixon, John/A-5318-2011
OI Dixon, John/0000-0001-6399-7010
CR Barnes M, 2004, AM J RESP CRIT CARE, V170, P656, DOI 10.1164/rccm.200311-1571OC
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   Benson K, 2000, NEW ENGL J MED, V342, P1878, DOI 10.1056/NEJM200006223422506
   BRIDGMAN SA, 2000, COCHRANE DB SYST REV, DOI DOI 10.1002/14651858.CD001004
   CASH T, 1994, MULTIDIMENTIONAL BOD
   Chapman AE, 2004, SURGERY, V135, P326, DOI 10.1016/S0039-6060(03)00392-1
   CHARUZI I, 1992, AM J CLIN NUTR, V55, P594, DOI 10.1093/ajcn/55.2.594s
   Colman PG, 1999, MED J AUSTRALIA, V170, P375, DOI 10.5694/j.1326-5377.1999.tb139171.x
   Concato J, 2000, NEW ENGL J MED, V342, P1887, DOI 10.1056/NEJM200006223422507
   Dixon AFR, 2005, J CLIN ENDOCR METAB, V90, P813, DOI 10.1210/jc.2004-1546
   Dixon JB, 2001, ARCH INTERN MED, V161, P102, DOI 10.1001/archinte.161.1.102
   Dixon JB, 2001, OBES RES, V9, P713, DOI 10.1038/oby.2001.96
   Dixon JB, 2003, CHEST, V123, P1134, DOI 10.1378/chest.123.4.1134
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   GRUNSTEIN RR, 1995, INT J OBESITY, V19, P410
   Guardiano SA, 2003, CHEST, V124, P1615, DOI 10.1378/chest.124.4.1615
   JOHNS MW, 1992, SLEEP, V15, P376, DOI 10.1093/sleep/15.4.376
   JOHNS MW, 1991, SLEEP, V14, P540, DOI 10.1093/sleep/14.6.540
   Kansanen M, 1998, CLIN PHYSIOL, V18, P377, DOI 10.1046/j.1365-2281.1998.00114.x
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   Kyzer S, 1998, WORLD J SURG, V22, P998, DOI 10.1007/s002689900506
   Lean MEJ, 1998, LANCET, V351, P853, DOI 10.1016/S0140-6736(97)10004-6
   Mehta A, 2001, AM J RESP CRIT CARE, V163, P1457, DOI 10.1164/ajrccm.163.6.2004213
   *MLF, 1983, HEIGHT WEIGHT TABL M
   Moyer CA, 2001, SLEEP MED, V2, P477, DOI 10.1016/S1389-9457(01)00072-7
   O'Brien PE, 2002, OBES SURG, V12, P652, DOI 10.1381/096089202321019639
   PASQUALI R, 1990, INT J OBESITY, V14, P207
   Rasheid S, 2003, OBES SURG, V13, P58, DOI 10.1381/096089203321136593
   Rechtschaffen A., 1968, MANUAL STANDARDIZED
   Scheuller M, 2001, OTOLARYNG HEAD NECK, V125, P299, DOI 10.1067/mhn.2001.119139
   *SDTF, 1992, SLEEP, V15, P173
   Serafini FM, 2001, OBES SURG, V11, P28, DOI 10.1381/096089201321454079
   *SPSS I, 1999, SPSS WIND 10 0 5
   SUGERMAN HJ, 1992, AM J CLIN NUTR, V55, P597, DOI 10.1093/ajcn/55.2.597s
   Vgontzas AN, 1998, ARCH INTERN MED, V158, P1333, DOI 10.1001/archinte.158.12.1333
   Vgontzas AN, 2003, J INTERN MED, V254, P32, DOI 10.1046/j.1365-2796.2003.01177.x
   Ware J.E., 1994, SF36 physical and mental health summary scales - A user's manual
   WARE JE, 1997, SF36 HLTH SURVEY MAN
   WHO Consultation on Obesity, 2000, Obesity: preventing and managing the global epidemic. Report of a who consultation, V894
   YOUNG T, 1993, NEW ENGL J MED, V328, P1230, DOI 10.1056/NEJM199304293281704
   Zimmet P, 2000, J INTERN MED, V247, P301, DOI 10.1046/j.1365-2796.2000.00625.x
   Zozula R, 2001, Curr Opin Pulm Med, V7, P391, DOI 10.1097/00063198-200111000-00005
NR 42
TC 113
Z9 124
U1 0
U2 5
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD SEP
PY 2005
VL 29
IS 9
BP 1048
EP 1054
DI 10.1038/sj.ijo.0802960
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 954CC
UT WOS:000231130700004
PM 15852048
DA 2025-06-11
ER

PT J
AU Dabek, J
   Kulach, A
   Wilczok, T
   Mazurek, U
   Jakubowski, D
   Gasior, Z
AF Dabek, Jozefa
   Kulach, Andrzej
   Wilczok, Tadeusz
   Mazurek, Urszula
   Jakubowski, Daniel
   Gasior, Zbigniew
TI Transcriptional activity of genes encoding interferon γ (IFNγ) and its
   receptor assessed in peripheral blood mononuclear cells in patients with
   cardiac syndrome X
SO INFLAMMATION
LA English
DT Article
DE interferon gamma; interferon receptor; cardiac syndrome X; gene
   expression
ID LEFT-VENTRICULAR FUNCTION; CORONARY-ARTERY-DISEASE; DYSFUNCTION;
   ACTIVATION; PROGNOSIS; APOPTOSIS
AB Background. Cardiac syndrome X is typically characterized by effort induced anginal pain with ST segment depression suggestive of myocardial ischemia and normal coronary arteries at angiography. The possible mechanism that may participate in the pathology of CSX is a microvascular dysfunction related to inflammatory process affecting endothelium. Interferon gamma (IFN-gamma) is an important cytokine in inflammatory reaction. It acts through its specific receptor composed of 2 subunitsIFN-gamma R1 (ligand binding) and R2 (signal transduction). The expression and proportion of these subunits influences IFN-gamma activity. The aim of the study was to assess the gene expression of IFN-gamma and its receptors in peripheral blood mononuclear cells (PBMC) from patients with syndrome X.
   Methods. The study was carried out in 36 patients aged 44-77 (average 57 years old) with cardiac syndrome X and 23 sex- and age-matched healthy subjects (control group). To evaluate gene expression of IFN gamma and its receptor total mRNA was extracted from peripheral blood mononuclear cells (PBMC) and the number of mRNA copies were assessed by quantitive reverse transcriptase polymerase chain reaction (QRT- PCR).
   Results. We have not observed statistically significant differences in INF gamma gene expression between studied group and control. Genes encoding IFN gamma receptor subunits showed higher expression in PBMCs from patients with cardiac syndrome X vs control subjects (IFN gamma R1, 97,244 +/- 26,956 c/mu g vs 12,120 +/- 2,940 c/mu g, p < 0.005, respectively and IFN gamma R2, 129,153 +/- 36,883 c/mu g vs 16,445 +/- 2,923 c/mu g, p < 0.005, respectively).
   Conclusion. Variation in transcriptional activity of genes encoding INF-gamma receptor subunits may affect function of microvasculature and thereby participate in the pathology of cardiac syndrome X.
C1 L Warynski Silesian Med Acad, Dept Cardiol, PL-40635 Katowice, Poland.
   L Warynski Silesian Med Acad, Dept Mol Genet & Med Genet, Sosnowiec, Poland.
C3 Medical University of Silesia; Medical University of Silesia
RP Kulach, A (corresponding author), L Warynski Silesian Med Acad, Dept Cardiol, Ziolowa 47, PL-40635 Katowice, Poland.
EM akulach@mp.pl
RI Kulach, Andrzej/ABF-3313-2020
OI Kulach, Andrzej/0000-0002-3140-1806
CR Allione A, 1999, J IMMUNOL, V163, P4182
   Deb DK, 2003, J IMMUNOL, V171, P267, DOI 10.4049/jimmunol.171.1.267
   Fernandes JL, 2004, CYTOKINE, V26, P131, DOI 10.1016/j.cyto.2004.01.007
   Hartrick CT, 2002, NEUROSCI LETT, V323, P75, DOI 10.1016/S0304-3940(02)00112-X
   Haus Olga, 2000, Archivum Immunologiae et Therapiae Experimentalis, V48, P95
   Inagaki Y, 2002, LIFE SCI, V71, P2499, DOI 10.1016/S0024-3205(02)02042-8
   Johnson BD, 2004, CIRCULATION, V109, P2993, DOI 10.1161/01.CIR.0000130642.79868.B2
   KASKI JC, 1995, J AM COLL CARDIOL, V25, P807, DOI 10.1016/0735-1097(94)00507-M
   KEMP HG, 1973, AM J CARDIOL, V32, P375, DOI 10.1016/S0002-9149(73)80150-X
   Koh KP, 2004, J CLIN INVEST, V114, P846, DOI 10.1172/JCI200421767
   KOLODZIEJ K, 2001, FORUM KARDIOL, V4, P1425
   Leu HB, 2006, FREE RADICAL BIO MED, V40, P983, DOI 10.1016/j.freeradbiomed.2005.10.047
   Lin CP, 2003, INT J CARDIOL, V89, P53, DOI 10.1016/S0167-5273(02)00428-X
   Panting JR, 2002, NEW ENGL J MED, V346, P1948, DOI 10.1056/NEJMoa012369
   Pestka S, 1997, SEMIN ONCOL, V24
   Reiss AB, 2004, MED SCI MONITOR, V10, pBR420
   Robertson B, 1997, NEUROREPORT, V8, P1311, DOI 10.1097/00001756-199703240-00050
   ROGACKA D, 2003, FOLIA CARDIOL, V10, P553
   TYMINSKASEDEK K, 2002, TERAPIA, V9, P41
   Vázquez-Rey E, 2003, REV ESP CARDIOL, V56, P181, DOI 10.1157/13043225
   Zhang P, 2004, CHINESE MED J-PEKING, V117, P79
NR 21
TC 10
Z9 13
U1 0
U2 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0360-3997
J9 INFLAMMATION
JI Inflammation
PD AUG
PY 2007
VL 30
IS 3-4
BP 125
EP 129
DI 10.1007/s10753-007-9028-0
PG 5
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA 181HM
UT WOS:000247427800006
PM 17546485
DA 2025-06-11
ER

PT J
AU Hong, KH
   Lee, Y
AF Hong, Ki-Hong
   Lee, Young
TI Negative Correlation Between Vitamin A and Positive Correlation Between
   Vitamin E and Inflammation Among Healthy Adults in Korea: Based on the
   Korea National Health and Nutrition Examination Survey (KNHANES)
   2016-2018 7th Edition
SO JOURNAL OF INFLAMMATION RESEARCH
LA English
DT Article
DE metabolic syndrome; retinol; alpha-tocopherol; smoking; drinking
ID GENDER-RELATED DIFFERENCES; SERUM ALPHA-TOCOPHEROL; GAMMA-TOCOPHEROL;
   RETINOIC ACID; ALCOHOL-CONSUMPTION; OXIDATIVE STRESS; AIR-POLLUTION;
   PROTEIN; OBESITY; SUPPLEMENTATION
AB Purpose: Vitamins exert its effect through different isoforms. The isoform conversion phases involved are affected outside factors. Here, we investigated the correlation between serum retinol, alpha-tocopherol, and serum inflammatory markers using stratified data acquired from 2016 to 2018 Korea National Health and Nutrition Examination Survey (KNHANES).
   Materials and Methods: This study was based on data acquired from the 7th edition (2016-2018) of the Korea National Health and Nutrition Examination Survey, consisting of survey data on smoking and alcohol drinking, serum retinol level, serum alpha-tocopherol level, high-sensitivity C-reactive protein (hs-CRP), and baseline characteristics.
   Results: There was a negative correlation between serum retinol and hs-CRP in alcohol drinking men. There was a negative correlation between serum retinol and hs-CRP in the alcohol-nonsmoking female group. There was a positive correlation between alpha-tocopherol and hs-CRP in the nonsmoking and alcohol-drinking group. There was a positive correlation between alpha-tocopherol and hs-CRP in the nonsmoking and alcohol-drinking female group. There was positive correlation between vitamin A and E and metabolic syndrome. The lowest vitamin A level was observed in subjects with all five metabolic syndrome criteria matched.
   Conclusion: There was a negative correlation between serum retinol and hs-CRP and positive correlation between alpha-tocopherol and hs-CRP. Absorption and secretion of serum retinol are affected by inflammation status through retinol-binding protein. Alcohol acts as a competitive inhibitor of vitamin A oxidation through alcohol dehydrogenase and ALDH activity. Smoking causes inflammation and induces reactive oxygen species scavenging system and increases cytochrome p450 levels. These factors may have contributed to the observed findings. Metabolic syndrome subjects increased as the levels of vitamin A and vitamin E increased. Since obesity is inversely related to ALDH activity, we postulate that patients with metabolic syndrome may also have low ALDH activity, especially in the Asian population. Future studies are warranted to study the efficacy of ALDH or ALDH inducers in patients with vitamin A deficiency or metabolic syndrome.
C1 [Hong, Ki-Hong] Seoul Vet Hosp, Nursing Hosp, Dept Family Med, 53,Jinhwangdo Ro 61 Gil, Seoul 05368, South Korea.
   [Lee, Young] Vet Hlth Serv Med Ctr, Vet Med Res Inst, Seoul 05368, South Korea.
C3 Seoul Veterans Hospital; Veterans Health Service Medical Center
RP Hong, KH (corresponding author), Seoul Vet Hosp, Nursing Hosp, Dept Family Med, 53,Jinhwangdo Ro 61 Gil, Seoul 05368, South Korea.
EM hkhtech@naver.com
RI Hong, Kihong/AAN-6883-2021
OI Hong, Kihong/0000-0001-6054-1456
CR Abdulla KA, 2018, J NUTR, V148, P1453, DOI 10.1093/jn/nxy132
   Chrostek L, 2003, J CLIN LAB ANAL, V17, P93, DOI 10.1002/jcla.10076
   Clugston RD, 2015, FASEB J, V29, P3654, DOI 10.1096/fj.14-266296
   Clugston RD, 2013, BBA-MOL CELL BIOL L, V1831, P1276, DOI 10.1016/j.bbalip.2013.04.006
   Cooney RV, 2008, NUTR CANCER, V60, P21, DOI 10.1080/01635580802404162
   COONEY RV, 1993, P NATL ACAD SCI USA, V90, P1771, DOI 10.1073/pnas.90.5.1771
   Devaraj S, 2008, FREE RADICAL BIO MED, V44, P1203, DOI 10.1016/j.freeradbiomed.2007.12.018
   Erkelens MN, 2017, TRENDS IMMUNOL, V38, P168, DOI 10.1016/j.it.2016.12.006
   GasconVila P, 1997, EUR J CLIN NUTR, V51, P723, DOI 10.1038/sj.ejcn.1600472
   Gieng SH, 2005, J LIPID RES, V46, P641, DOI 10.1194/jlr.M400415-JLR200
   Gieng SH, 2007, J LIPID RES, V48, P904, DOI 10.1194/jlr.M600528-JLR200
   Godala Malgorzata, 2014, Pol Merkur Lekarski, V36, P320
   Greer Ristan M, 2004, J Cyst Fibros, V3, P143, DOI 10.1016/j.jcf.2004.04.003
   Gudas LJ, 2011, J CELL PHYSIOL, V226, P322, DOI 10.1002/jcp.22417
   Hartman TJ, 2005, EUR J CLIN NUTR, V59, P161, DOI 10.1038/sj.ejcn.1602051
   Hess DA, 2020, CELL REP MED, V1, DOI 10.1016/j.xcrm.2020.100018
   Hosomi A, 1997, FEBS LETT, V409, P105, DOI 10.1016/S0014-5793(97)00499-7
   Huang ZY, 2018, J CLIN MED, V7, DOI 10.3390/jcm7090258
   HUNT TK, 1986, J AM ACAD DERMATOL, V15, P817, DOI 10.1016/S0190-9622(86)70238-7
   Jiang Q, 2003, FASEB J, V17, P816, DOI 10.1096/fj.02-0877com
   Jiang Q, 2000, P NATL ACAD SCI USA, V97, P11494, DOI 10.1073/pnas.200357097
   Lanki T, 2015, ENVIRON HEALTH PERSP, V123, P785, DOI 10.1289/ehp.1408224
   Liu C, 2003, J NUTR, V133, P173, DOI 10.1093/jn/133.1.173
   Mitra AK, 1998, LANCET, V351, P1033, DOI 10.1016/S0140-6736(05)79000-0
   Nandini Yadav Nandini Yadav, 2016, Journal of Chemical and Pharmaceutical Research, V8, P595
   Newaz MA, 2003, J PHYSIOL PHARMACOL, V54, P319
   Ou-Yang DS, 2000, BRIT J CLIN PHARMACO, V49, P145, DOI 10.1046/j.1365-2125.2000.00128.x
   Reiter E, 2007, MOL ASPECTS MED, V28, P668, DOI 10.1016/j.mam.2007.01.003
   Rizvi Saliha, 2014, Sultan Qaboos Univ Med J, V14, pe157
   Rojas AI, 1999, DERMATOL SURG, V25, P601, DOI 10.1046/j.1524-4725.1999.99074.x
   Rückerl R, 2007, ENVIRON HEALTH PERSP, V115, P1072, DOI 10.1289/ehp.10021
   SARKER SA, 1986, ARCH DIS CHILD, V61, P739, DOI 10.1136/adc.61.8.739
   Seitz HK, 2000, GUT, V47, P748, DOI 10.1136/gut.47.6.748
   Singh U, 2004, ANN NY ACAD SCI, V1031, P195, DOI 10.1196/annals.1331.019
   Soprano DR, 2007, VITAM HORM, V75, P69, DOI 10.1016/S0083-6729(06)75003-8
   STEPHENSEN CB, 1994, AM J CLIN NUTR, V60, P388, DOI 10.1093/ajcn/60.3.388
   Stephensen CB, 2001, ANNU REV NUTR, V21, P167, DOI 10.1146/annurev.nutr.21.1.167
   Tabesh M, 2017, J RES MED SCI, V22, DOI 10.4103/1735-1995.200270
   Talwar D, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011312
   Wei XP, 2016, ASIA PAC J CLIN NUTR, V25, P563, DOI 10.6133/apjcn.092015.03
   White E, 2001, ANN EPIDEMIOL, V11, P136, DOI 10.1016/S1047-2797(00)00189-7
   World Med Assoc, 2013, JAMA-J AM MED ASSOC, V310, P2191, DOI 10.1001/jama.2013.281053
   Zaiden N, 2010, J ATHEROSCLER THROMB, V17, P1019, DOI 10.5551/jat.4911
   Zhao L, 2015, INT J OBESITY, V39, P438, DOI 10.1038/ijo.2014.124
   Zou Y, 2014, INT J ENV RES PUB HE, V11, P1647, DOI 10.3390/ijerph110201647
NR 45
TC 6
Z9 7
U1 1
U2 3
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-7031
J9 J INFLAMM RES
JI J. Inflamm. Res.
PY 2020
VL 13
BP 799
EP 811
DI 10.2147/JIR.S265856
PG 13
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA OO8UY
UT WOS:000587650900001
PM 33154657
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lahouel, A
AF Lahouel, Asma
TI High sugar consumption for seven days in adult mice increased blood
   glucose variability, induced an anxiolytic effect and triggered
   oxidative stress in cerebral cortex
SO METABOLIC BRAIN DISEASE
LA English
DT Article
DE Brain; Glucose variability; Sucrose; Oxidative stress; Anxiolytic
   behavior
ID SPRAGUE-DAWLEY RATS; SHORT-TERM; ALZHEIMERS-DISEASE; METABOLIC SYNDROME;
   CAFETERIA DIET; ANXIETY; BRAIN; HIPPOCAMPUS; BEHAVIORS; FRUCTOSE
AB Brain function is highly altered by glucose toxicity related to diabetes. High consumption of sugar in normal conditions is suspected to affect as well brain integrity. The present study investigates the possible effects of short-term exposure to high sugar diet on brain redox homeostasis in healthy mice. Male adult healthy mice were divided into two groups: control (CG) and sugar-exposed group (SG), that was exposed continually to 10% of glucose in drinking water for 7 days and 20% sucrose pellets food. Behavior, blood glucose variability and cerebral cortex oxidative stress biomarkers were measured at the end of exposure. Animals exposed to the high sugar diet expressed a significant increase in blood glucose levels and high glucose variability compared to control. These animals expressed as well anxiolytic behavior as revealed by the plus maze test. Exposure to the sugar diet altered redox homeostasis in the brain cortex as revealed by an increase in lipid peroxidation and the activity of antioxidant enzymes superoxide dismutase (SOD) and glutathione-s-transferase (GST). On the other hand, catalase (CAT) activity was decreased, and reduced glutathione (GSH) level was not altered compared to control. Further studies are required to understand the mechanisms trigging oxidative stress (OS) in the brain in response to short term exposure to high sugar diet and glucose fluctuations.
C1 [Lahouel, Asma] Univ Jijel, Fac Exact Sci & Comp Sci, Lab Pharmacol & Phytochemistry, Jijel 18000, Algeria.
   [Lahouel, Asma] Univ Jijel, Fac Nat & Life Sci, Dept Mol & Cellular Biol, Jijel 18000, Algeria.
C3 Universite de Jijel; Universite de Jijel
RP Lahouel, A (corresponding author), Univ Jijel, Fac Exact Sci & Comp Sci, Lab Pharmacol & Phytochemistry, Jijel 18000, Algeria.; Lahouel, A (corresponding author), Univ Jijel, Fac Nat & Life Sci, Dept Mol & Cellular Biol, Jijel 18000, Algeria.
EM Asma.lahouel@univ-jijel.dz
FU Algerian Directorate-General for Scientific Research and Technological
   Development (DGRSDT)
FX The author acknowledges the Algerian Directorate-General for Scientific
   Research and Technological Development (DGRSDT) for providing support
   during the preparation of this work.
CR AEBI H, 1984, METHOD ENZYMOL, V105, P121
   Beauchamp C., 1971, ANAL BIOCHEM, V44, P276, DOI DOI 10.1016/0003-2697(71)90370-8
   Beilharz JE, 2016, BEHAV BRAIN RES, V306, P1, DOI 10.1016/j.bbr.2016.03.018
   Beilharz JE, 2014, BRAIN BEHAV IMMUN, V37, P134, DOI 10.1016/j.bbi.2013.11.016
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Camacho-Castillo L, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-98983-w
   Casetta I, 2005, CURR PHARM DESIGN, V11, P2033, DOI 10.2174/1381612054065729
   Cigliano L, 2018, MOL NEUROBIOL, V55, P2869, DOI 10.1007/s12035-017-0518-2
   de la Monte SM, 2006, J ALZHEIMERS DIS, V9, P167
   ELLMAN GL, 1959, ARCH BIOCHEM BIOPHYS, V82, P70, DOI 10.1016/0003-9861(59)90090-6
   Freeman CR, 2018, FRONT BIOSCI-LANDMRK, V23, P2255, DOI 10.2741/4704
   Gancheva S, 2017, INT J EXP PATHOL, V98, P296, DOI 10.1111/iep.12254
   Geijselaers SLC, 2015, LANCET DIABETES ENDO, V3, P75, DOI 10.1016/S2213-8587(14)70148-2
   HABIG WH, 1974, J BIOL CHEM, V249, P7130
   Hansen MK, 1998, AM J PHYSIOL-REG I, V274, pR1734, DOI 10.1152/ajpregu.1998.274.6.R1734
   Hsieh CF, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-37215-0
   Jorgensen BP, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0103398
   Larqué C, 2011, IUBMB LIFE, V63, P831, DOI 10.1002/iub.544
   Leffa DD, 2015, METAB BRAIN DIS, V30, P1073, DOI 10.1007/s11011-015-9682-0
   Li XH, 2015, CLIN INTERV AGING, V10, P549, DOI 10.2147/CIA.S74042
   LISTER RG, 1987, PSYCHOPHARMACOLOGY, V92, P180
   Liu LJ, 2022, NUTR NEUROSCI, V25, P2302, DOI 10.1080/1028415X.2021.1959099
   Lopes A, 2014, MOL NEUROBIOL, V50, P1124, DOI 10.1007/s12035-014-8676-y
   Martinez M, 2021, BMJ OPEN DIAB RES CA, V9, DOI 10.1136/bmjdrc-2020-002032
   Mathis A, 2018, NAT NEUROSCI, V21, P1281, DOI 10.1038/s41593-018-0209-y
   Mergenthaler P, 2013, TRENDS NEUROSCI, V36, P587, DOI 10.1016/j.tins.2013.07.001
   Miao HY, 2021, JPAD-J PREV ALZHEIM, V8, P188, DOI 10.14283/jpad.2020.62
   Murphy M, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/701967
   Nunomura A, 2001, J NEUROPATH EXP NEUR, V60, P759, DOI 10.1093/jnen/60.8.759
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   Ohland CL, 2016, NUTR NEUROSCI, V19, P337, DOI 10.1179/1476830515Y.0000000034
   Parfitt GM, 2017, NEUROPSYCHOPHARMACOL, V42, P1715, DOI 10.1038/npp.2017.56
   Patki G, 2013, BRAIN RES, V1539, P73, DOI 10.1016/j.brainres.2013.09.033
   Pranprawit A, 2013, J SCI FOOD AGR, V93, P3191, DOI 10.1002/jsfa.6240
   Prasad A, 1996, PHYSIOL BEHAV, V60, P1039, DOI 10.1016/0031-9384(96)00135-7
   Quincozes-Santos A, 2017, BBA-MOL BASIS DIS, V1863, P1, DOI 10.1016/j.bbadis.2016.09.013
   Ramanathan M., 1999, Indian Journal of Experimental Biology, V37, P182
   Rao CH, 2022, INT J OPHTHALMOL-CHI, V15, P1908, DOI 10.18240/ijo.2022.12.03
   Rebolledo-Solleiro D, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0176554
   Salim S, 2017, J PHARMACOL EXP THER, V360, P201, DOI 10.1124/jpet.116.237503
   Souza CG, 2007, LIFE SCI, V81, P198, DOI 10.1016/j.lfs.2007.05.001
   Sun B, 2021, CARDIOVASC DIABETOL, V20, DOI 10.1186/s12933-020-01200-7
   Tomlinson DR, 2008, NAT REV NEUROSCI, V9, P36, DOI 10.1038/nrn2294
   Treviño S, 2015, SYNAPSE, V69, P421, DOI 10.1002/syn.21832
   Velasco M, 2012, ISLETS, V4, P302, DOI 10.4161/isl.21374
   Vincent AM, 2005, FASEB J, V19, P638, DOI 10.1096/fj.04-2513fje
   Warneke W, 2014, PHARMACOL BIOCHEM BE, V116, P45, DOI 10.1016/j.pbb.2013.11.016
   Watt C, 2020, NUTRIENTS, V12, DOI 10.3390/nu12123906
   Xu F, 2015, HUM BRAIN MAPP, V36, P707, DOI 10.1002/hbm.22658
   Yang JP, 2019, BIOCHEM BIOPH RES CO, V510, P35, DOI 10.1016/j.bbrc.2018.12.179
   Yin JB, 2022, NEUROSCI LETT, V788, DOI 10.1016/j.neulet.2022.136851
NR 51
TC 1
Z9 1
U1 0
U2 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0885-7490
EI 1573-7365
J9 METAB BRAIN DIS
JI Metab. Brain Dis.
PD JUN
PY 2024
VL 39
IS 5
BP 731
EP 739
DI 10.1007/s11011-024-01352-5
EA MAY 2024
PG 9
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA YP3S6
UT WOS:001216055500001
PM 38720093
DA 2025-06-11
ER

PT J
AU Schwarz, R
   Decker, L
   Seeberg, I
   Miskowiak, KW
   Kessing, LV
   Vinberg, M
AF Schwarz, Rasmus
   Decker, Lone
   Seeberg, Ida
   Miskowiak, Kamilla Woznica
   Kessing, Lars Vedel
   Vinberg, Maj
TI Affective disorders: eliminate WArning signs and REstore functioning -
   AWARE - a randomised controlled multimodule intervention study,
   presentation of design and intervention
SO BMJ OPEN
LA English
DT Article
DE Depression & mood disorders; Adult psychiatry; MENTAL HEALTH
ID MAJOR DEPRESSIVE DISORDER; QUALITY-OF-LIFE; BIPOLAR DISORDER;
   RATING-SCALE; INTERNATIONAL CLASSIFICATION; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; PROCESS SKILLS; CORE SETS; VALIDATION
AB Introduction Affective disorders are associated with impaired overall functioning and quality of life (QoL). Despite different medical and psychological treatment options, the prognosis remains largely unchanged. Consequently, the field needs new intervention strategies especially targeting patient groups with impaired functioning. This study aims to improve functioning and QoL in patients with affective disorders using a comprehensive 360 degrees intervention.
   Methods and analysis Affective disorders: eliminate WArning signs And REstore (AWARE) functioning is a randomised, controlled, parallel-group design study. Participants will be 120 outpatients, men or women, aged 18-65 years, with a diagnosis of bipolar disorder or major depressive disorder. Inclusion requires an objectively rated impaired functioning defined as a score >= 11 according to the Functioning Assessment Short Test. Participants will be randomised to 6-month AWARE intervention or treatment as usual (TAU). The AWARE intervention is a 360 degrees multimodal intervention based on the International Classification of Functioning Brief Core Set for bipolar and unipolar disorder targeting functioning. The primary outcome is improvement of observation-based activities of daily living (ADL) ability using Assessment of Motor and Process Skills. Secondary outcomes are changes from baseline to endpoint in functioning, QoL, stress, cognition and physical health. Our hypothesis is that the AWARE treatment in comparison with TAU will improve observed ability to perform ADL, patients self-perceived level of functioning and QoL.
   Status: currently recruiting patients.
   Ethics and dissemination Ethical approval has been obtained from The Regional Ethics Committee in the Capital Region of Denmark. All patients will be provided oral and written information about the trial before informed consent is obtained. The study results will be disseminated by peer-review publications. If the present AWARE intervention shows beneficial effects, the goal is to use it as a template for future interventions addressing disability in patients with affective disorders as well as for patients within other diagnostic categories.
C1 [Schwarz, Rasmus] North Zealand Psychiat Ctr, Res Unit, Hillerod, Denmark.
   [Schwarz, Rasmus; Kessing, Lars Vedel; Vinberg, Maj] Univ Copenhagen, Dept Clin Med, Fac Hlth & Med Sci, Copenhagen, Denmark.
   [Decker, Lone] Metropolitan Univ Coll, Dept Physiotherapy & Occupat Therapy, Copenhagen, Denmark.
   [Seeberg, Ida] North Zealand Psychiat Ctr, Dept Dialect Behav Therapy, Hillerod, Denmark.
   [Miskowiak, Kamilla Woznica] Copenhagen Univ Hosp, Neurocognit & Emot Affect Disorder NEAD Grp, Copenhagen Affect Disorder Res Ctr CADIC, Psychiat Ctr Copenhagen, Copenhagen, Denmark.
   [Miskowiak, Kamilla Woznica] Univ Copenhagen, Dept Psychol, Copenhagen, Denmark.
   [Kessing, Lars Vedel] Copenhagen Univ Hosp, Copenhagen Affect Disorder Res Ctr CADIC, Psychiat Ctr Copenhagen, Copenhagen, Denmark.
C3 University of Copenhagen; University of Copenhagen; Copenhagen
   University Hospital; University of Copenhagen; University of Copenhagen;
   Copenhagen University Hospital
RP Schwarz, R (corresponding author), North Zealand Psychiat Ctr, Res Unit, Hillerod, Denmark.; Schwarz, R (corresponding author), Univ Copenhagen, Dept Clin Med, Fac Hlth & Med Sci, Copenhagen, Denmark.
EM rasmus.einar.vagn.schwarz@regionh.dk
RI Kessing, Lars/JNS-2493-2023; Vinberg/ABC-7493-2021
OI Schwarz, Rasmus/0000-0002-8808-1866; Miskowiak,
   Kamilla/0000-0003-2572-1384; Kessing, Lars/0000-0001-9377-9436
FU Capital Region of Denmark [F-61181-03-16]; Occupational Therapists'
   Research Foundation; A.P. Moller Foundation for the Advancement of
   Medical Science; TRYG Foundation; Mental Health Services
FX The study is funded via the Mental Health Services, Capital Region of
   Denmark (grant number F-61181-03-16), the Occupational Therapists'
   Research Foundation (grant number N/A), the A.P. Moller Foundation for
   the Advancement of Medical Science (grant number N/A) and the TRYG
   Foundation (grant number N/A). The initiative for the study was taken by
   doctors and researchers at the Psychiatric Center Copenhagen and at the
   Copenhagen University College who are not affiliated with the donors.
CR Altman EG, 1997, BIOL PSYCHIAT, V42, P948, DOI 10.1016/S0006-3223(96)00548-3
   [Anonymous], 1992, Trail making test: manual for administration and scoring
   [Anonymous], 2002, The world health report 2002: reducing risks to health, promoting healthy life (World health reports)
   [Anonymous], 1999, COPING INVENTORY STR
   Avila CC, 2010, BIPOLAR DISORD, V12, P473, DOI 10.1111/j.1399-5618.2010.00833.x
   Ayuso-Mateos JL, 2013, DISABIL REHABIL, V35, P2138, DOI 10.3109/09638288.2013.771708
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   Bernstein DP, 2003, CHILD ABUSE NEGLECT, V27, P169, DOI 10.1016/S0145-2134(02)00541-0
   Bo QJ, 2019, NEUROPSYCH DIS TREAT, V15, P1649, DOI 10.2147/NDT.S201567
   Bonnín CM, 2018, J AFFECT DISORDERS, V240, P57, DOI 10.1016/j.jad.2018.07.045
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1016/0165-1781(89)90047-4
   Cappuccio FP, 2010, SLEEP, V33, P585, DOI 10.1093/sleep/33.5.585
   Cieza A, 2004, J REHABIL MED, V36, P128, DOI 10.1080/16501960410016055
   Cloutier M, 2018, J AFFECT DISORDERS, V226, P45, DOI 10.1016/j.jad.2017.09.011
   Coello K, 2019, AUST NZ J PSYCHIAT, V53, P651, DOI 10.1177/0004867418815987
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   CRAWFORD JR, 1987, BRIT J CLIN PSYCHOL, V26, P313, DOI 10.1111/j.2044-8260.1987.tb01366.x
   Crowe M, 2010, INT J NURS STUD, V47, P896, DOI 10.1016/j.ijnurstu.2010.02.012
   Dahl TH, 2002, J REHABIL MED, V34, P201, DOI 10.1080/165019702760279170
   Decker L. T. C., 2017, EDORIUM J DISABILITY, V3, P69
   Ekholm O, 2009, SCAND J PUBLIC HEALT, V37, P758, DOI 10.1177/1403494809341095
   Eysenck H. J., 1975, Manual of the Eysenck Personality Questionnaire (Junior and Adult)
   Ferrari AJ, 2016, BIPOLAR DISORD, V18, P440, DOI 10.1111/bdi.12423
   Fisher A.G., 2012, Assessment of Motor and Process SKills: Development, standardization, and administration manual, V1
   Gitlin MJ, 2017, J AFFECT DISORDERS, V209, P147, DOI 10.1016/j.jad.2016.11.021
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Hansen HV, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0032950
   Harper A, 1998, PSYCHOL MED, V28, P551, DOI 10.1017/S0033291798006667
   Harris PA, 2009, J BIOMED INFORM, V42, P377, DOI 10.1016/j.jbi.2008.08.010
   Henry BL, 2013, PSYCHIAT RES, V210, P850, DOI 10.1016/j.psychres.2013.04.006
   Hoffmann TC, 2014, BMJ-BRIT MED J, V348, DOI [10.1136/bmj.g1687, 10.1055/s-0041-111066]
   Jensen JH, 2015, J AFFECT DISORDERS, V187, P10, DOI 10.1016/j.jad.2015.07.039
   Jonas BS, 2010, DISABIL HEALTH J, V3, P171, DOI 10.1016/j.dhjo.2009.11.001
   KENDLER KS, 1995, AM J PSYCHIAT, V152, P833
   Kessing LV, 2021, J AFFECT DISORDERS, V282, P18, DOI 10.1016/j.jad.2020.12.072
   Kessing LV, 2013, BRIT J PSYCHIAT, V202, P212, DOI 10.1192/bjp.bp.112.113548
   Kessing LV, 2006, SOC PSYCH PSYCH EPID, V41, P148, DOI 10.1007/s00127-005-0012-4
   Kessing LV, 2004, BRIT J PSYCHIAT, V185, P372, DOI 10.1192/bjp.185.5.372
   Levy Boaz, 2012, Depress Res Treat, V2012, P949248, DOI 10.1155/2012/949248
   LINGJAERDE O, 1987, ACTA PSYCHIAT SCAND, V76, P7
   Matthiessen J, 2008, EUR J EPIDEMIOL, V23, P311, DOI 10.1007/s10654-008-9228-4
   Mausbach BT, 2010, BIPOLAR DISORD, V12, P45, DOI 10.1111/j.1399-5618.2009.00787.x
   McIntyre RS, 2013, ADV THER, V30, P577, DOI 10.1007/s12325-013-0040-5
   McNulty MC, 2001, AM J OCCUP THER, V55, P649, DOI 10.5014/ajot.55.6.649
   Moran P, 2003, BRIT J PSYCHIAT, V183, P228, DOI 10.1192/bjp.183.3.228
   Nielsen KT, 2015, SCAND J OCCUP THER, V22, P13, DOI 10.3109/11038128.2014.961547
   Nordentoft M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055176
   Norman SB, 2006, DEPRESS ANXIETY, V23, P245, DOI 10.1002/da.20182
   Oakley F, 2002, ACTA PSYCHIAT SCAND, V105, P231, DOI 10.1034/j.1600-0447.2002.1sc021.x
   Ott CV, 2021, BIPOLAR DISORD, V23, P487, DOI 10.1111/bdi.13021
   PAN AW, 1994, AM J OCCUP THER, V48, P775, DOI 10.5014/ajot.48.9.775
   Purdon S.E., 2005, The screen for cognitive impairment in psychiatry (scip): Instructions and three alternate forms
   Rosa Adriane R, 2007, Clin Pract Epidemiol Ment Health, V3, P5, DOI 10.1186/1745-0179-3-5
   Rosa AR, 2013, J AFFECT DISORDERS, V150, P29, DOI 10.1016/j.jad.2013.02.022
   Sanchez-Moreno J, 2009, PSYCHOTHER PSYCHOSOM, V78, P285, DOI 10.1159/000228249
   Sanchez-Moreno J, 2010, DISABIL REHABIL, V32, pS94, DOI 10.3109/09638288.2010.520810
   Sheehan DV, 1998, J CLIN PSYCHIAT, V59, P22, DOI 10.4088/JCP.09m05305whi
   Slyepchenko A, 2019, AUST NZ J PSYCHIAT, V53, P683, DOI 10.1177/0004867419829228
   Torrent C, 2013, AM J PSYCHIAT, V170, P852, DOI 10.1176/appi.ajp.2012.12070971
   Träger C, 2017, PSYCHIAT RES, V249, P268, DOI 10.1016/j.psychres.2016.12.058
   Vancampfort D, 2019, J AFFECT DISORDERS, V251, P149, DOI 10.1016/j.jad.2019.03.076
   Vancampfort D, 2016, J AFFECT DISORDERS, V201, P145, DOI 10.1016/j.jad.2016.05.020
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vancampfort D, 2013, AM J PSYCHIAT, V170, P265, DOI 10.1176/appi.ajp.2012.12050620
   Varghese S, 2022, ACTA PSYCHIAT SCAND, V145, P156, DOI 10.1111/acps.13385
   Wahrens E E., 2010, Measuring Quality of Occupational Performance Based on Self-report and Observation: Development and Validation of Instruments to Evaluate ADL Task Performance
   Wittchen HU, 2011, EUR NEUROPSYCHOPHARM, V21, P655, DOI 10.1016/j.euroneuro.2011.07.018
   World Health O., 2005, INT CLASSIFICATION D
   Yin JW, 2017, J AM HEART ASSOC, V6, DOI [10.1161/JAHA.117.005947, 10.1161/jaha.117.005947]
   YOUNG RC, 1978, BRIT J PSYCHIAT, V133, P429, DOI 10.1192/bjp.133.5.429
NR 70
TC 3
Z9 3
U1 0
U2 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD MAY
PY 2022
VL 12
IS 5
AR e058839
DI 10.1136/bmjopen-2021-058839
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 1S6VA
UT WOS:000804185600002
PM 35618335
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Xu, QY
   Anderson, D
   Lurie-Beck, J
AF Xu, Qunyan
   Anderson, Debra
   Lurie-Beck, Janine
TI The relationship between abdominal obesity and depression in the general
   population: A systematic review and meta-analysis
SO OBESITY RESEARCH & CLINICAL PRACTICE
LA English
DT Review
DE Abdominal obesity; Depression; Cross-sectional studies; Meta-analysis
ID BODY-MASS INDEX; METABOLIC SYNDROME; WAIST CIRCUMFERENCE; CARDIOVASCULAR
   RISK; YOUNG-ADULTS; HIP RATIO; SYMPTOMS; ASSOCIATION; DISEASE; HEALTH
AB Obesity has been widely regarded as a public health concern because of its adverse impact on individuals' health. Systematic reviews have been published in examining the effect of obesity on depression, but with major emphasis on general obesity as measured by the body mass index. Despite a stronger effect of abdominal obesity on individuals' physical health outcomes, to our best knowledge, no systematic review was undertaken with regard to the relationship between abdominal obesity and depression. This paper reports the results of a systematic review and meta-analysis of cross-sectional studies examining the relationship between abdominal obesity and depression in a general population. Multiple electronic databases were searched until the end of September 2009. 15 articles were systematically reviewed and meta-analyzed. The analysis showed that the odds ratio of having depression for individuals with abdominal obesity was 1.38 (95% CI, 1.22-1.57) as compared to those who are not obese. Furthermore, it was found that this relationship did not vary with potential confounders including gender, age, measurement of depression and abdominal obesity, and study quality. (C) 2011 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
C1 [Xu, Qunyan; Anderson, Debra] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld 4001, Australia.
   [Lurie-Beck, Janine] Queensland Univ Technol, Sch Psychol & Counseling, Fac Hlth, Brisbane, Qld 4001, Australia.
C3 Queensland University of Technology (QUT); Queensland University of
   Technology (QUT)
RP Xu, QY (corresponding author), N Block,QUT Kelvin Grove Campus,Victoria Pk Rd, Kelvin Grove, Qld 4059, Australia.
EM qunyan.xu@student.qut.edu.au
RI Anderson, Debra/I-9637-2012; Xu, Qunyan/F-4193-2013
OI Xu, Qunyan/0000-0002-2486-9814; Anderson, Debra/0000-0001-8996-9624
CR Ahlberg AC, 2002, PSYCHIAT RES, V112, P101, DOI 10.1016/S0165-1781(02)00192-0
   Akbaraly TN, 2009, DIABETES CARE, V32, P499, DOI 10.2337/dc08-1358
   Ali S, 2006, DIABETIC MED, V23, P1165, DOI 10.1111/j.1464-5491.2006.01943.x
   [Anonymous], 2001, Practical meta-analysis effect size calculator
   Atlantis E, 2008, INT J OBESITY, V32, P881, DOI 10.1038/ijo.2008.54
   Azadbakht L, 2008, PUBLIC HEALTH NUTR, V11, P528, DOI 10.1017/S1368980007000882
   BERLIN JA, 1995, AM J EPIDEMIOL, V142, P383, DOI 10.1093/oxfordjournals.aje.a117645
   Beydoun MA, 2009, AM J CLIN NUTR, V90, P1084, DOI 10.3945/ajcn.2009.27782
   Blaine B, 2008, J HEALTH PSYCHOL, V13, P1190, DOI 10.1177/1359105308095977
   Bornstein SR, 2006, MOL PSYCHIATR, V11, P892, DOI 10.1038/sj.mp.4001873
   Capuron L, 2009, J AFFECT DISORDERS, V119, P181, DOI 10.1016/j.jad.2009.02.017
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   de Wit L, 2010, PSYCHIAT RES, V178, P230, DOI 10.1016/j.psychres.2009.04.015
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   Egger M, 1997, BMJ-BRIT MED J, V315, P629, DOI 10.1136/bmj.315.7109.629
   Eskandari F, 2005, METABOLISM, V54, P918, DOI 10.1016/j.metabol.2005.02.006
   Fairfield KM, 2002, OBSTET GYNECOL, V100, P288, DOI 10.1016/S0029-7844(02)02053-7
   Gariepy G, 2010, INT J OBESITY, V34, P407, DOI 10.1038/ijo.2009.252
   Gil Katarzyna, 2006, Kardiol Pol, V64, P464
   Gillespie CF, 2005, PSYCHOSOM MED, V67, pS26, DOI 10.1097/01.psy.0000163456.22154.d2
   Goldbacher EM, 2007, ANN BEHAV MED, V34, P240, DOI 10.1007/BF02874549
   Hach I, 2006, J AFFECT DISORDERS, V92, P305, DOI 10.1016/j.jad.2006.01.023
   Haukkala A, 2000, INT J EAT DISORDER, V27, P106, DOI 10.1002/(SICI)1098-108X(200001)27:1<106::AID-EAT13>3.0.CO;2-5
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Herva A, 2006, INT J OBESITY, V30, P520, DOI 10.1038/sj.ijo.0803174
   Hess Z, 2004, Cas Lek Cesk, V143, P840
   Higgins J, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.ED000049
   Hildrum B, 2009, ACTA PSYCHIAT SCAND, V120, P14, DOI 10.1111/j.1600-0447.2008.01315.x
   Ho RCM, 2008, INT J GERIATR PSYCH, V23, P401, DOI 10.1002/gps.1893
   Jacka FN, 2007, PSYCHOSOMATICS, V48, P54, DOI 10.1176/appi.psy.48.1.54
   Janssen I, 2004, AM J CLIN NUTR, V79, P379
   Janssen I, 2002, AM J CLIN NUTR, V75, P683, DOI 10.1093/ajcn/75.4.683
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178, DOI 10.4088/JCP.v69n0202
   Laudisio A, 2009, J GERIATR PSYCH NEUR, V22, P215, DOI 10.1177/0891988709335793
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Ma J, 2010, OBESITY, V18, P347, DOI 10.1038/oby.2009.213
   Mast BT, 2008, BIOL PSYCHIAT, V64, P320, DOI 10.1016/j.biopsych.2008.01.025
   McIntyre RS, 2009, CURR DIABETES REP, V9, P51, DOI 10.1007/s11892-009-0010-0
   Mhurchu CN, 2006, ASIA PAC J CLIN NUTR, V15, P287
   Miettola J, 2008, SCAND J PRIM HEALTH, V26, P203, DOI 10.1080/02813430802117624
   Miller AH, 1999, ADV EXP MED BIOL, V461, P107
   Muhtz C, 2009, PSYCHONEUROENDOCRINO, V34, P1004, DOI 10.1016/j.psyneuen.2009.01.016
   Onat A, 2005, METABOLISM, V54, P800, DOI 10.1016/j.metabol.2005.01.025
   Pace TWW, 2009, ANN NY ACAD SCI, V1179, P86, DOI 10.1111/j.1749-6632.2009.04984.x
   Penninx BWJH, 2001, ARCH GEN PSYCHIAT, V58, P221, DOI 10.1001/archpsyc.58.3.221
   Puhl RM, 2010, AM J PUBLIC HEALTH, V100, P1019, DOI 10.2105/AJPH.2009.159491
   Pulkki-Råback L, 2009, HEALTH PSYCHOL, V28, P108, DOI 10.1037/a0012646
   Räikkönen K, 1999, INT J OBESITY, V23, P775, DOI 10.1038/sj.ijo.0800917
   RAIKKONEN K, 1994, J BEHAV MED, V17, P605, DOI 10.1007/BF01857600
   Rice M, 2008, 61 ANN SCI M RES AG
   Rivenes AC, 2009, J PSYCHOSOM RES, V66, P269, DOI 10.1016/j.jpsychores.2008.07.012
   ROSENTHAL R, 1979, PSYCHOL BULL, V86, P638, DOI 10.1037/0033-2909.86.3.638
   Shoelson SE, 2007, GASTROENTEROLOGY, V132, P2169, DOI 10.1053/j.gastro.2007.03.059
   Stroup DF, 2000, JAMA-J AM MED ASSOC, V283, P2008, DOI 10.1001/jama.283.15.2008
   Takeuchi T, 2009, DIABETES METAB, V35, P32, DOI 10.1016/j.diabet.2008.06.006
   Toker S, 2008, DEPRESS ANXIETY, V25, P661, DOI 10.1002/da.20379
   Turley M, 2006, AUST NZ J PUBL HEAL, V30, P231, DOI 10.1111/j.1467-842X.2006.tb00863.x
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
   Viinamäki H, 2009, ACTA PSYCHIAT SCAND, V120, P23, DOI 10.1111/j.1600-0447.2008.01333.x
   Vogelzangs N, 2007, J GERONTOL A-BIOL, V62, P563, DOI 10.1093/gerona/62.5.563
   Vogelzangs N, 2007, PSYCHONEUROENDOCRINO, V32, P151, DOI 10.1016/j.psyneuen.2006.11.009
   Vogelzangs N, 2009, AM J GERIAT PSYCHIAT, V17, P716, DOI 10.1097/JGP.0b013e3181aad5d7
   Wells GA., 2014, The Newcastle -Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta -analyses, DOI DOI 10.1007/S10654-010-9491-Z
   Williams LJ, 2009, J AFFECT DISORDERS, V118, P173, DOI 10.1016/j.jad.2009.02.001
   WING RR, 1991, ARTERIOSCLER THROMB, V11, P1250, DOI 10.1161/01.ATV.11.5.1250
   Zhu SK, 2005, AM J CLIN NUTR, V81, P409
NR 67
TC 89
Z9 95
U1 2
U2 32
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-403X
EI 1878-0318
J9 OBES RES CLIN PRACT
JI Obes. Res. Clin. Pract.
PD OCT-DEC
PY 2011
VL 5
IS 4
BP E267
EP E278
DI 10.1016/j.orcp.2011.04.007
PG 12
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 981GX
UT WOS:000306956100001
PM 24331129
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Vancampfort, D
   Stubbs, B
   Richards, J
   Ward, PB
   Firth, J
   Schuch, FB
   Rosenbaum, S
AF Vancampfort, Davy
   Stubbs, Brendon
   Richards, Justin
   Ward, Philip B.
   Firth, Joseph
   Schuch, Felipe B.
   Rosenbaum, Simon
TI Physical fitness in people with posttraumatic stress disorder: a
   systematic review
SO DISABILITY AND REHABILITATION
LA English
DT Review
DE Stress; trauma; PTSD; physical activity; exercise; physical fitness
ID METABOLIC SYNDROME; MENTAL-DISORDERS; CHRONIC PAIN; MORTALITY; EXERCISE;
   RISK; PTSD; ANTIPSYCHOTICS; COMORBIDITY; PERFORMANCE
AB Purpose: People with posttraumatic stress disorder (PTSD) have an increased risk of cardiovascular diseases (CVD). Physical fitness is a key modifiable risk factor for CVD and associated mortality. We reviewed the evidence-base regarding physical fitness in people with PTSD.
   Methods: Two independent reviewers searched PubMed, CINAHL, PsycARTICLES, PEDro, and SPORTDiscus from inception until May 2016 using the key words "fitness" OR "exercise" AND "posttraumatic stress disorder" OR "PTSD".
   Results: In total, 5 studies involving 192 (44 female) individuals with PTSD met the inclusion criteria. Lower baseline physical fitness are associated with greater reductions in avoidance and hyperarousal symptoms, as well as with total, physical, and social symptoms of anxiety sensitivity. Rigorous data comparing physical fitness with age-and gender matched general population controls are currently lacking.
   Conclusions: The research field regarding physical fitness in people with PTSD is still in its infancy. Given the established relationships between physical fitness, morbidity and mortality in the general population and the current gaps in the PTSD literature, targets for future research include exploring: (a) whether people with PTSD are at risk of low physical fitness and therefore in need of intensified assessment, treatment and follow-up, (b) the relationships among physical fitness, overall health status, chronic disease risk reduction, disability, and mortality in individuals PTSD, (c) psychometric properties of submaximal physical fitness tests in PTSD, (d) physical fitness changes following physical activity in PTSD, and (e) optimal methods of integrating physical activity programs within current treatment models for PTSD.
C1 [Vancampfort, Davy] Univ Leuven, KU Leuven, Dept Rehabil Sci, Leuven, Belgium.
   [Vancampfort, Davy] Katholieke Univ Leuven, Campus Kortenberg, Kortenberg, Belgium.
   [Vancampfort, Davy] UPC KU Leuven, Univ Leuven, Leuven, Belgium.
   [Stubbs, Brendon] South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, Denmark Hill, London, England.
   [Stubbs, Brendon] Kings Coll London, Inst Psychiat, Hlth Serv, De Crespigny Pk, London, England.
   [Stubbs, Brendon] Kings Coll London, Inst Psychiat, Populat Res Dept, De Crespigny Pk, London, England.
   [Richards, Justin] Univ Sydney, Charles Perkins Ctr, Sch Publ Hlth, Sydney, NSW, Australia.
   [Ward, Philip B.] UNSW Australia, Sch Psychiat, Sydney, NSW, Australia.
   [Ward, Philip B.] Ingham Inst Appl Med Res, Schizophrenia Res Unit, Liverpool, NSW, Australia.
   [Firth, Joseph] Univ Manchester, Inst Brain Behav & Mental Hlth, Manchester, Lancs, England.
   [Schuch, Felipe B.] Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil.
   [Schuch, Felipe B.] Univ Fed Rio Grande do Sul, Programa Pos Grad Ciencias Med Psiquiatria, Porto Alegre, RS, Brazil.
   [Rosenbaum, Simon] UNSW Australia, Sch Med Sci, Dept Exercise Physiol, Sydney, NSW, Australia.
C3 KU Leuven; KU Leuven; KU Leuven; University of London; King's College
   London; University of London; King's College London; University of
   Sydney; University of New South Wales Sydney; Ingham Institute for
   Applied Medical Research; University of Manchester; Hospital de Clinicas
   de Porto Alegre; Universidade Federal do Rio Grande do Sul; University
   of New South Wales Sydney
RP Vancampfort, D (corresponding author), UPC KU Leuven, Campus Kortenberg, B-3070 Kortenberg, Belgium.
EM davy.vancampfort@kuleuven.be
RI Schuch, Felipe/AAF-5028-2019; Firth, Joseph/JOZ-1679-2023; Rosenbaum,
   Simon/Y-3241-2019; Stubbs, Brendon/X-1904-2018; Vancampfort,
   Davy/AAD-1987-2019; Schuch, Felipe/L-4620-2016; Stubbs,
   Brendon/C-5696-2015; Ward, Philip/JCE-6293-2023
OI Schuch, Felipe/0000-0002-5190-4515; Stubbs, Brendon/0000-0001-7387-3791;
   Richards, Justin/0000-0003-4584-8614; Ward, Philip/0000-0002-5779-7722;
   Rosenbaum, Simon/0000-0002-8984-4941
FU Research Foundation Flanders (FWO-Vlaanderen); Society for Mental Health
   Research (SMHR); Applied Health Research and Care South London theme
FX This research received no specific grant from any funding agency in the
   public, commercial, or not-for-profit sectors. Davy Vancampfort has got
   support from the Research Foundation Flanders (FWO-Vlaanderen). Simon
   Rosenbaum is funded by a Society for Mental Health Research (SMHR) Early
   Career Fellowship. Brendon Stubbs was supported by the Collaboration for
   Leadership in Applied Health Research and Care South London theme. No
   sources of funding were used to assist in the preparation of this
   article.
CR Afari N, 2014, PSYCHOSOM MED, V76, P2, DOI 10.1097/PSY.0000000000000010
   Ahmadi N, 2011, AM J CARDIOL, V108, P29, DOI 10.1016/j.amjcard.2011.02.340
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   [Anonymous], 2013, DIAGNOSTIC STAT MANU, VFifth, P1000
   [Anonymous], 2009, ACSMS GUIDELINES EXE
   Bauer MS, 2014, PHARMACOEPIDEM DR S, V23, P77, DOI 10.1002/pds.3507
   Blanco C, 2013, DRUG ALCOHOL DEPEN, V132, P630, DOI 10.1016/j.drugalcdep.2013.04.016
   Boscarino JA, 2006, ANN EPIDEMIOL, V16, P248, DOI 10.1016/j.annepidem.2005.03.009
   Bouchard C, 2015, MAYO CLIN PROC, V90, P1533, DOI 10.1016/j.mayocp.2015.08.005
   Brennstuhl MJ, 2015, PERSPECT PSYCHIATR C, V51, P295, DOI 10.1111/ppc.12093
   Carmassi C, 2015, PSYCHIAT RES, V225, P64, DOI 10.1016/j.psychres.2014.10.008
   Correll CU, 2015, WORLD PSYCHIATRY, V14, P119, DOI 10.1002/wps.20204
   Crapo RO, 2002, AM J RESP CRIT CARE, V166, P111, DOI 10.1164/rccm.166/1/111
   Dedert EA, 2010, ANN BEHAV MED, V39, P61, DOI 10.1007/s12160-010-9165-9
   Eraly SA, 2014, JAMA PSYCHIAT, V71, P423, DOI 10.1001/jamapsychiatry.2013.4374
   Fetzner MG, 2015, COGN BEHAV THERAPY, V44, P301, DOI 10.1080/16506073.2014.916745
   Fu SS, 2007, NICOTINE TOB RES, V9, P1071, DOI 10.1080/14622200701488418
   GURALNIK JM, 1994, J GERONTOL, V49, pM85, DOI 10.1093/geronj/49.2.M85
   Hall KS, 2014, J REHABIL RES DEV, V51, P285, DOI 10.1682/JRRD.2013.04.0091
   Hallgren M, 2016, FRONT PSYCHIATRY, V7, DOI 10.3389/fpsyt.2016.00036
   Kodama S, 2009, JAMA-J AM MED ASSOC, V301, P2024, DOI 10.1001/jama.2009.681
   LeBouthillier DM, 2016, MENT HEALTH PHYS ACT, V10, P33, DOI 10.1016/j.mhpa.2015.11.001
   Lederman O, 2016, AUSTRALAS PSYCHIATRY, V24, P347, DOI 10.1177/1039856216632400
   Nevell L, 2014, PSYCHONEUROENDOCRINO, V43, P62, DOI 10.1016/j.psyneuen.2014.01.013
   PATE RR, 1988, QUEST, V40, P174, DOI 10.1080/00336297.1988.10483898
   Rosenbaum S, 2015, ACTA PSYCHIAT SCAND, V131, P350, DOI 10.1111/acps.12371
   Rosenbaum S, 2015, PSYCHIAT RES, V230, P130, DOI 10.1016/j.psychres.2015.10.017
   Rosenbaum S, 2015, METABOLISM, V64, P926, DOI [10.1016/j.metabol.2015.04.009, 10.1016/j.metabol.2015.01.016]
   Rosenbaum S, 2011, BMC PSYCHIATRY, V11, DOI 10.1186/1471-244X-11-115
   Scioli-Salter E, 2016, J REHABIL RES DEV, V53, P95, DOI 10.1682/JRRD.2014.10.0267
   Skinner J., 1994, PHYS ACTIVITY FITNES
   Stubbs B, 2014, BRIT J PSYCHIAT, V204, P164, DOI 10.1192/bjp.204.2.164
   Vancampfort D, 2016, J PHYS ACT HEALTH, V13, P910, DOI 10.1123/jpah.2015-0436
   Vancampfort D, 2016, PSYCHOSOM MED, V78, P465, DOI 10.1097/PSY.0000000000000297
   Vancampfort D, 2012, DISABIL REHABIL, V34, P1, DOI 10.3109/09638288.2011.587090
   Wolf EJ, 2016, PSYCHOL MED, V46, P2215, DOI 10.1017/S0033291716000817
   Xue Y, 2012, AM J CARDIOL, V109, P1215, DOI 10.1016/j.amjcard.2011.11.063
   Young Men's Christian Association, 1989, YS WAY PHYS FITN
   Zen AL, 2012, HEALTH PSYCHOL, V31, P194, DOI 10.1037/a0025989
NR 39
TC 26
Z9 28
U1 1
U2 21
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-8288
EI 1464-5165
J9 DISABIL REHABIL
JI Disabil. Rehabil.
PY 2017
VL 39
IS 24
BP 2461
EP 2467
DI 10.1080/09638288.2016.1226412
PG 7
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Rehabilitation
GA FG7CG
UT WOS:000410565300001
PM 27628485
DA 2025-06-11
ER

PT J
AU Fabianová, K
   Babel'ová, J
   Fabian, D
   Popovicová, A
   Martoncíková, M
   Racek, A
   Raceková, E
AF Fabianova, Kamila
   Babel'ova, Janka
   Fabian, Dusan
   Popovicova, Alexandra
   Martoncikova, Marcela
   Racek, Adam
   Racekova, Eniko
TI Maternal High-Energy Diet during Pregnancy and Lactation Impairs
   Neurogenesis and Alters the Behavior of Adult Offspring in a
   Phenotype-Dependent Manner
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE maternal nutrition; obesity; subventricular zone; rostral migratory
   stream; neurogenesis; high-energy diet; cell proliferation; cell
   degeneration; nitric oxide
ID HIGH-FAT DIET; SUBVENTRICULAR ZONE NEUROGENESIS; ROSTRAL MIGRATORY
   STREAM; HIPPOCAMPAL NEUROGENESIS; INDUCED OBESITY; NITRIC-OXIDE;
   CELL-PROLIFERATION; METABOLIC SYNDROME; COGNITIVE IMPAIRMENT;
   INSULIN-RESISTANCE
AB Obesity is one of the biggest and most costly health challenges the modern world encounters. Substantial evidence suggests that the risk of metabolic syndrome or obesity formation may be affected at a very early stage of development, in particular through fetal and/or neonatal overfeeding. Outcomes from epidemiological studies indicate that maternal nutrition during pregnancy and lactation has a profound impact on adult neurogenesis in the offspring. In the present study, an intergenerational dietary model employing overfeeding of experimental mice during prenatal and early postnatal development was applied to acquire mice with various body conditions. We investigated the impact of the maternal high-energy diet during pregnancy and lactation on adult neurogenesis in the olfactory neurogenic region involving the subventricular zone (SVZ) and the rostral migratory stream (RMS) and some behavioral tasks including memory, anxiety and nociception. Our findings show that a maternal high-energy diet administered during pregnancy and lactation modifies proliferation and differentiation, and induced degeneration of cells in the SVZ/RMS of offspring, but only in mice where extreme phenotype, such as significant overweight/adiposity or obesity is manifested. Thereafter, a maternal high-energy diet enhances anxiety-related behavior in offspring regardless of its body condition and impairs learning and memory in offspring with an extreme phenotype.
C1 [Fabianova, Kamila; Popovicova, Alexandra; Martoncikova, Marcela; Racek, Adam; Racekova, Eniko] Slovak Acad Sci, Biomed Res Ctr, Inst Neurobiol, Soltesovej 4, Kosice 04001, Slovakia.
   [Babel'ova, Janka; Fabian, Dusan] Slovak Acad Sci, Ctr Biosci, Inst Anim Physiol, Soltesovej 4-6, Kosice 04001, Slovakia.
C3 Slovak Academy of Sciences; Institute of Neurobiology, SAS; Slovak
   Academy of Sciences; Institute of Animal Physiology, SAS; Centre of
   Biosciences, SAS
RP Fabianová, K (corresponding author), Slovak Acad Sci, Biomed Res Ctr, Inst Neurobiol, Soltesovej 4, Kosice 04001, Slovakia.
EM fabianova@saske.sk; kubandova@saske.sk; fabian@saske.sk;
   popovicova@saske.sk; martoncikova@saske.sk; racek@saske.sk;
   racekova@saske.sk
RI Babeľová, Janka/GZL-1878-2022; Fabian, Dusan/M-3770-2017; Martoncikova,
   Marcela/F-3622-2018; Fabianova, Kamila/AAR-3211-2021; Racekova,
   Eniko/AGO-9200-2022
OI Babelova, Janka/0000-0002-9606-9795; Fabian, Dusan/0000-0003-3216-2058;
   Martoncikova, Marcela/0000-0001-5418-1693; Fabianova,
   Kamila/0000-0003-2965-4625; Racekova, Eniko/0000-0002-3650-2251
FU European Regional Development Fund [ITMS: 313011V344, ITMS: 313011V455];
    [APVV-19-0279]
FX This research was funded by APVV-19-0279. This publication was created
   thanks to support under the Operational Programme Integrated
   Infrastructure for the projects: Long-term strategic research of
   prevention, intervention and mechanisms of obesity and its
   comorbidities, ITMS: 313011V344 and Open scientific community for modern
   interdisciplinary research in medicine, ITMS: 313011V455, co-financed by
   the European Regional Development Fund.
CR Ahirwar R, 2019, DIABETES METAB SYND, V13, P318, DOI 10.1016/j.dsx.2018.08.032
   Albanese Emiliano, 2017, Alzheimers Dement (Amst), V8, P165, DOI 10.1016/j.dadm.2017.05.007
   Almeida-Suhett CP, 2017, PHYSIOL BEHAV, V169, P130, DOI 10.1016/j.physbeh.2016.11.016
   Alvarez-Buylla A, 2002, BRAIN RES BULL, V57, P751, DOI 10.1016/S0361-9230(01)00770-5
   Apple DM, 2019, AGING-US, V11, P115, DOI 10.18632/aging.101731
   Bedi KS, 2003, NUTR NEUROSCI, V6, P141, DOI 10.1080/1028415031000098549
   Bertrand PC, 2006, J NUTR, V136, P1570, DOI 10.1093/jn/136.6.1570
   Bilbo SD, 2010, FASEB J, V24, P2104, DOI 10.1096/fj.09-144014
   Biyong EF, 2021, INT J OBESITY, V45, P588, DOI 10.1038/s41366-020-00723-z
   Blaschke AJ, 1996, DEVELOPMENT, V122, P1165
   Boitard C, 2014, BRAIN BEHAV IMMUN, V40, P9, DOI 10.1016/j.bbi.2014.03.005
   Boitard C, 2012, HIPPOCAMPUS, V22, P2095, DOI 10.1002/hipo.22032
   Boney CM, 2005, PEDIATRICS, V115, pE290, DOI 10.1542/peds.2004-1808
   Nakandakari SCBR, 2019, BRAIN BEHAV IMMUN, V79, P284, DOI 10.1016/j.bbi.2019.02.016
   Bruce-Keller AJ, 2009, BBA-MOL BASIS DIS, V1792, P395, DOI 10.1016/j.bbadis.2008.10.004
   Butler MJ, 2021, BRAIN BEHAV IMMUN-HL, V16, DOI 10.1016/j.bbih.2021.100298
   Cadena-Burbano EV, 2019, NUTR NEUROSCI, V22, P98, DOI 10.1080/1028415X.2017.1354958
   Carnell S, 2012, INT REV PSYCHIATR, V24, P189, DOI 10.3109/09540261.2012.676988
   Carreira BP, 2014, FRONT CELL NEUROSCI, V8, DOI 10.3389/fncel.2014.00343
   Chang GQ, 2008, J NEUROSCI, V28, P12107, DOI 10.1523/JNEUROSCI.2642-08.2008
   Cheke LG, 2017, NEUROPSYCHOLOGIA, V96, P137, DOI 10.1016/j.neuropsychologia.2017.01.013
   Chen HL, 2004, AM J EPIDEMIOL, V159, P547, DOI 10.1093/aje/kwh059
   Cheung PC, 2016, CHILD OBES, V12, P1, DOI 10.1089/chi.2015.0055
   Chin SH, 2020, INT J OBESITY, V44, P969, DOI 10.1038/s41366-019-0505-y
   Christie BR, 2006, HIPPOCAMPUS, V16, P199, DOI 10.1002/hipo.20151
   Cordner ZA, 2015, PHYSIOL BEHAV, V152, P363, DOI 10.1016/j.physbeh.2015.06.008
   Cutler RR, 2020, CURR OPIN PHARMACOL, V50, P1, DOI 10.1016/j.coph.2019.10.005
   Danat IM, 2019, J ALZHEIMERS DIS, V70, pS87, DOI 10.3233/JAD-180763
   Daoust J, 2021, NEUROSCI BIOBEHAV R, V129, P133, DOI 10.1016/j.neubiorev.2021.07.020
   DelPrado M, 1997, J NUTR, V127, P458, DOI 10.1093/jn/127.3.458
   Desai M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113326
   Doetsch F, 1996, P NATL ACAD SCI USA, V93, P14895, DOI 10.1073/pnas.93.25.14895
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Edlow AG, 2017, PRENATAL DIAG, V37, P95, DOI 10.1002/pd.4932
   Fabianová K, 2014, BEHAV BRAIN RES, V265, P38, DOI 10.1016/j.bbr.2014.01.023
   Fabricius K, 2008, BRAIN STRUCT FUNCT, V212, P403, DOI 10.1007/s00429-007-0169-6
   Férézou-Viala J, 2007, AM J PHYSIOL-REG I, V293, pR1056, DOI 10.1152/ajpregu.00117.2007
   Ferreira A, 2018, NEUROBIOL LEARN MEM, V155, P197, DOI 10.1016/j.nlm.2018.07.014
   Fischer Andrew H, 2008, CSH Protoc, V2008, DOI 10.1101/pdb.prot4986
   Fruh SM, 2017, J AM ASSOC NURSE PRA, V29, pS3, DOI 10.1002/2327-6924.12510
   Galvao RP, 2008, J NEUROSCI, V28, P13368, DOI 10.1523/JNEUROSCI.2918-08.2008
   Gould TD, 2009, NEUROMETHODS, V42, P1, DOI 10.1007/978-1-60761-303-9_1
   Hersey M, 2021, BRAIN BEHAV IMMUN, V96, P63, DOI 10.1016/j.bbi.2021.05.010
   Hill JO, 1998, SCIENCE, V280, P1371, DOI 10.1126/science.280.5368.1371
   Huot RL, 2002, BRAIN RES, V950, P52, DOI 10.1016/S0006-8993(02)02985-2
   Huynh MJ, 2020, UROL ONCOL-SEMIN ORI, V38, DOI 10.1016/j.urolonc.2020.05.014
   Hwang IK, 2008, BRAIN RES, V1241, P1, DOI 10.1016/j.brainres.2008.08.024
   Hwang LL, 2010, OBESITY, V18, P463, DOI 10.1038/oby.2009.273
   Jacques A, 2019, NEUROSCI BIOBEHAV R, V103, P178, DOI 10.1016/j.neubiorev.2019.05.021
   Janssen F, 2020, OBESITY FACTS, V13, P514, DOI 10.1159/000511023
   Johnson SA, 2017, J DEV ORIG HLTH DIS, V8, P75, DOI 10.1017/S2040174416000490
   Jones HN, 2009, FASEB J, V23, P271, DOI 10.1096/fj.08-116889
   Kanoski SE, 2011, PHYSIOL BEHAV, V103, P59, DOI 10.1016/j.physbeh.2010.12.003
   Kempermann G, 2000, NOVART FDN SYMP, V231, P220, DOI 10.1002/0470870834.ch14
   Kesby JP, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0140034
   Kim DG, 2016, J NEUROINFLAMM, V13, DOI 10.1186/s12974-015-0467-5
   Kim S, 2018, NEUROPHARMACOLOGY, V130, P10, DOI 10.1016/j.neuropharm.2017.11.041
   Kirschenbaum B, 1999, J NEUROSCI, V19, P2171
   Kivipelto M, 2005, ARCH NEUROL-CHICAGO, V62, P1556, DOI 10.1001/archneur.62.10.1556
   Klein C, 2019, NEUROSCIENCE, V400, P146, DOI 10.1016/j.neuroscience.2018.12.037
   Klein C, 2016, NEUROBIOL LEARN MEM, V131, P26, DOI 10.1016/j.nlm.2016.03.002
   Knight EM, 2014, NEUROBIOL AGING, V35, P1821, DOI 10.1016/j.neurobiolaging.2014.02.010
   Kokoeva MV, 2007, J COMP NEUROL, V505, P209, DOI 10.1002/cne.21492
   Kopelman PG, 2000, NATURE, V404, P635, DOI 10.1038/35007508
   Kothari V, 2017, BBA-MOL BASIS DIS, V1863, P499, DOI 10.1016/j.bbadis.2016.10.006
   Kubandová J, 2014, PHYSIOL RES, V63, P103, DOI 10.33549/physiolres.932547
   Lagisz M, 2015, INT J OBESITY, V39, P1669, DOI 10.1038/ijo.2015.160
   Larsen CM, 2010, ENDOCRINOLOGY, V151, P3805, DOI 10.1210/en.2009-1385
   Lee S, 2018, EXP NEUROBIOL, V27, P277, DOI 10.5607/en.2018.27.4.277
   Lee THY, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22010201
   Leigh SJ, 2020, TRANSL PSYCHIAT, V10, DOI 10.1038/s41398-020-0734-9
   Lemamsha H, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/8531360
   Leone L, 2014, MOL NEUROBIOL, V49, P1472, DOI 10.1007/s12035-014-8650-8
   Lépinay AL, 2015, PSYCHONEUROENDOCRINO, V53, P82, DOI 10.1016/j.psyneuen.2014.12.008
   Leventopoulos M, 2007, BRAIN RES, V1142, P119, DOI 10.1016/j.brainres.2007.01.039
   Levin BE, 1998, AM J PHYSIOL-REG I, V274, pR412, DOI 10.1152/ajpregu.1998.274.2.R412
   Li E, 2014, EXP NEUROL, V252, P75, DOI 10.1016/j.expneurol.2013.11.021
   Lievajová K, 2011, EUR J HISTOCHEM, V55, P182, DOI 10.4081/ejh.2011.e33
   Lin C, 2021, ENDOCRINOLOGY, V162, DOI 10.1210/endocr/bqaa214
   López-Taboada I, 2020, FRONT PSYCHOL, V11, DOI 10.3389/fpsyg.2020.564413
   Loredo-Pérez AA, 2016, OBESITY, V24, P1106, DOI 10.1002/oby.21485
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Malik VS, 2013, AM J CLIN NUTR, V98, P1084, DOI 10.3945/ajcn.113.058362
   Markowitz S, 2008, CLIN PSYCHOL-SCI PR, V15, P1, DOI 10.1111/j.1468-2850.2008.00106.x
   Matarredona ER, 2004, BRAIN RES, V995, P274, DOI 10.1016/j.brainres.2003.10.010
   Matta J, 2018, PRESSE MED, V47, P434, DOI 10.1016/j.lpm.2018.03.023
   McMillen IC, 2005, PHYSIOL REV, V85, P571, DOI 10.1152/physrev.00053.2003
   McNay DEG, 2012, J CLIN INVEST, V122, P142, DOI 10.1172/JCI43134
   Melchior M, 2022, EUR J NEUROSCI, V55, P2216, DOI 10.1111/ejn.15153
   Mendes-da-Silva C, 2014, ARQ NEURO-PSIQUIAT, V72, P136
   Mercer JG, 2008, EUR J PHARMACOL, V585, P31, DOI 10.1016/j.ejphar.2007.11.077
   Miller AA, 2014, BRAIN BEHAV IMMUN, V42, P10, DOI 10.1016/j.bbi.2014.04.001
   Miola A, 2022, J AFFECT DISORDERS, V297, P169, DOI 10.1016/j.jad.2021.10.032
   Mobley AS, 2013, NEUROBIOL AGING, V34, P1873, DOI 10.1016/j.neurobiolaging.2013.01.015
   Mogil JS, 1999, PAIN, V80, P67, DOI 10.1016/S0304-3959(98)00197-3
   Moraes JC, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005045
   Moreno-López B, 2004, J NEUROSCI, V24, P85, DOI 10.1523/JNEUROSCI.1574-03.2004
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   NICHOLAS KR, 1991, COMP BIOCHEM PHYS A, V98, P535, DOI 10.1016/0300-9629(91)90443-G
   Niculescu MD, 2009, INT J DEV NEUROSCI, V27, P627, DOI 10.1016/j.ijdevneu.2009.08.005
   Noble EE, 2019, NUTR NEUROSCI, V22, P273, DOI 10.1080/1028415X.2017.1378851
   Ogrodnik M, 2019, CELL METAB, V29, P1061, DOI [10.1016/j.cmet.2018.12.008, 10.1016/j.cmet.2019.01.013]
   Park HR, 2010, NEUROSCI LETT, V482, P235, DOI 10.1016/j.neulet.2010.07.046
   Peleg-Raibstein D, 2012, BEHAV BRAIN RES, V233, P398, DOI 10.1016/j.bbr.2012.05.027
   Pencea V, 2001, EXP NEUROL, V172, P1, DOI 10.1006/exnr.2001.7768
   Peretto P, 1999, BRAIN RES BULL, V49, P221, DOI 10.1016/S0361-9230(99)00037-4
   Pérez-García G, 2016, SCI REP-UK, V6, DOI 10.1038/srep21275
   Plagemann A, 2006, HORM RES, V65, P83, DOI 10.1159/000091511
   Poulose SM, 2017, ADV NUTR, V8, P804, DOI 10.3945/an.117.016261
   Qi YH, 2015, NUTR HOSP, V31, P185, DOI 10.3305/nh.2015.31.1.7967
   Raceková E, 2009, CELL MOL NEUROBIOL, V29, P811, DOI 10.1007/s10571-009-9362-x
   Rains JL, 2011, FREE RADICAL BIO MED, V50, P567, DOI 10.1016/j.freeradbiomed.2010.12.006
   Rivera P, 2011, EUR J NEUROSCI, V33, P1577, DOI 10.1111/j.1460-9568.2011.07650.x
   Robison LS, 2020, ENEURO, V7, DOI 10.1523/ENEURO.0391-19.2019
   Rodriguez JS, 2012, INT J DEV NEUROSCI, V30, P75, DOI 10.1016/j.ijdevneu.2011.12.012
   Rojczyk-Golebiewska E, 2014, CELL MOL NEUROBIOL, V34, P631, DOI 10.1007/s10571-014-0058-5
   Romero-Grimaldi C, 2006, EUR J NEUROSCI, V24, P2461, DOI 10.1111/j.1460-9568.2006.05127.x
   Salberg Sabrina, 2021, Cereb Cortex Commun, V2, ptgab014, DOI 10.1093/texcom/tgab014
   Samant NP, 2021, METAB BRAIN DIS, V36, P1565, DOI 10.1007/s11011-021-00756-x
   Sasaki A, 2014, NEUROSCIENCE, V272, P92, DOI 10.1016/j.neuroscience.2014.04.012
   Sasaki A, 2013, NEUROSCIENCE, V240, P1, DOI 10.1016/j.neuroscience.2013.02.044
   Sharma S, 2013, INT J OBESITY, V37, P382, DOI 10.1038/ijo.2012.48
   Sharma S, 2021, PHYSIOL BEHAV, V240, DOI 10.1016/j.physbeh.2021.113528
   Sullivan Elinor L, 2012, Int J Obes Suppl, V2, pS7
   Szele FG, 1996, J COMP NEUROL, V368, P439, DOI 10.1002/(SICI)1096-9861(19960506)368:3<439::AID-CNE9>3.0.CO;2-6
   Tashani OA, 2017, EUR J PAIN, V21, P1186, DOI 10.1002/ejp.1019
   Thaler JP, 2012, J CLIN INVEST, V122, P153, DOI 10.1172/JCI59660
   Thompson Debra L, 2007, AAOHN J, V55, P265
   Torensma B, 2017, SURG OBES RELAT DIS, V13, P788, DOI 10.1016/j.soard.2017.01.015
   Torensma B, 2016, OBES SURG, V26, P631, DOI 10.1007/s11695-015-2008-9
   Torroglosa A, 2007, STEM CELLS, V25, P88, DOI 10.1634/stemcells.2006-0131
   Tozuka Y, 2010, NEUROCHEM INT, V57, P235, DOI 10.1016/j.neuint.2010.05.015
   Tozuka Y, 2009, FASEB J, V23, P1920, DOI 10.1096/fj.08-124784
   Tramullas M, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0155367
   Tremmel M, 2017, INT J ENV RES PUB HE, V14, DOI 10.3390/ijerph14040435
   Trottier G, 1998, ENDOCRINOLOGY, V139, P3704, DOI 10.1210/en.139.9.3704
   Ungvari Z, 2008, CIRC RES, V102, P519, DOI 10.1161/CIRCRESAHA.107.168369
   Val-Laillet D, 2020, NEUROSCI LETT, V739, DOI 10.1016/j.neulet.2020.135395
   Val-Laillet D, 2017, FASEB J, V31, P2037, DOI 10.1096/fj.201601015R
   Vickers MH, 2000, AM J PHYSIOL-ENDOC M, V279, pE83
   Weinstein DE, 1996, BRAIN RES, V743, P11, DOI 10.1016/S0006-8993(96)00979-1
   Weiss R, 2004, NEW ENGL J MED, V350, P2362, DOI 10.1056/NEJMoa031049
   Whitaker RC, 2004, PEDIATRICS, V114, pE29, DOI 10.1542/peds.114.1.e29
   Wojtowicz JM, 2006, HIPPOCAMPUS, V16, P261, DOI 10.1002/hipo.20158
   Xavier S, 2021, BRAIN BEHAV IMMUN, V98, P185, DOI 10.1016/j.bbi.2021.08.223
   Yang TY, 2020, NUTRIENTS, V12, DOI 10.3390/nu12092721
   Yeh SHH, 2020, NEUROBIOL AGING, V90, P60, DOI 10.1016/j.neurobiolaging.2019.11.018
   Yeomans MR, 2017, P NUTR SOC, V76, P455, DOI 10.1017/S0029665117000805
   Zhang Y, 2013, NEUROSCIENCE, V244, P31, DOI 10.1016/j.neuroscience.2013.03.061
   Zuloaga KL, 2016, J CEREBR BLOOD F MET, V36, P1257, DOI 10.1177/0271678X15616400
NR 150
TC 4
Z9 4
U1 2
U2 13
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAY
PY 2022
VL 23
IS 10
AR 5564
DI 10.3390/ijms23105564
PG 25
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 1Q1OO
UT WOS:000802466200001
PM 35628378
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Naqvi, HA
   Wang, D
   Glozier, N
   Grunstein, RR
AF Naqvi, Haider A.
   Wang, David
   Glozier, Nicholas
   Grunstein, Ronald R.
TI Sleep-Disordered Breathing and Psychiatric Disorders
SO CURRENT PSYCHIATRY REPORTS
LA English
DT Article
DE Sleep apnoea; Depression; Schizophrenia; Bipolar disorder; Substance
   abuse; CPAP
ID POSITIVE AIRWAY PRESSURE; QUALITY-OF-LIFE; DAYTIME SLEEPINESS;
   DEPRESSIVE SYMPTOMS; BIPOLAR DISORDER; ORAL APPLIANCE; METABOLIC
   SYNDROME; MAJOR DEPRESSION; APNEA-HYPOPNEA; CPAP TREATMENT
AB Sleep-disordered breathing, the commonest form of which is obstructive sleep apnoea (OSA) is increasingly recognised as a treatable cause of morbidity. It shares many risk factors with psychiatric disorders including behaviours such as smoking and physical comorbidity. Many symptoms of the two overlap, leaving OSA often undetected and undertreated. In the few studies that assess the two, OSA is commonly comorbid with depression (17-45 %) and schizophrenia (up to 55 %) and possibly bipolar. There is some limited evidence that treating OSA can ameliorate psychiatric symptoms. Some psychotropics, such as narcotics, cause sleep-disordered breathing (SDB), whilst weight-inducing neuroleptics may exacerbate it. An extreme form of SDB, sudden infant death syndrome (SIDS), is a risk in mothers with substance abuse. Being aware of these common comorbidities may help improve psychiatric patient's treatment and quality of life.
C1 [Naqvi, Haider A.; Wang, David; Grunstein, Ronald R.] Woolcock Inst Med Res, Sleep & Circadian Grp, Sydney, NSW 2037, Australia.
   [Wang, David; Grunstein, Ronald R.] Royal Prince Alfred Hosp, Dept Resp & Sleep Med, Camperdown, NSW 2050, Australia.
   [Wang, David; Glozier, Nicholas; Grunstein, Ronald R.] Univ Sydney, Ctr Integrated Res & Understanding Sleep CIRUS, Sydney, NSW 2006, Australia.
   [Glozier, Nicholas] Univ Sydney, Discipline Psychiat, Brain & Mind Res Inst, Sydney, NSW 2006, Australia.
C3 University of Sydney; Woolcock Institute of Medical Research; NSW
   Health; Royal Prince Alfred Hospital; University of Sydney; University
   of Sydney; University of Sydney
RP Naqvi, HA (corresponding author), Woolcock Inst Med Res, Sleep & Circadian Grp, 431 Glebe Point Rd Glebe, Sydney, NSW 2037, Australia.
EM haider.naqvi93@yahoo.com
RI Glozier, Nick/A-7440-2011
OI Glozier, Nick/0000-0002-0476-9146; Grunstein,
   Ronald/0000-0001-6682-5812; Wang, David/0000-0002-3975-6214
FU NHMRC (Centre of Research Excellence-Neurosleep)
FX Nicholas Glozier has received a grant from the NHMRC (Centre of Research
   Excellence-Neurosleep).
CR Aggarwal R, 2013, BIPOLAR DISORD, V15, P803, DOI 10.1111/bdi.12112
   Akashiba T, 2002, CHEST, V122, P861, DOI 10.1378/chest.122.3.861
   Al Lawati NM, 2009, PROG CARDIOVASC DIS, V51, P285, DOI 10.1016/j.pcad.2008.08.001
   Alam A, 2012, GEN HOSP PSYCHIAT, V34, P660, DOI 10.1016/j.genhosppsych.2012.06.015
   Ancoli-Israel S, 1999, BIOL PSYCHIAT, V45, P1426, DOI 10.1016/S0006-3223(98)00166-8
   Andrade L, 2003, INT J METH PSYCH RES, V12, P3, DOI 10.1002/mpr.138
   Annamalai A, 2015, PSYCHOSOMATICS, V56, P59, DOI 10.1016/j.psym.2014.02.009
   [Anonymous], 2005, INT CLASSIFICATION S, V2nd
   Bardwell Wayne A, 2007, Behav Sleep Med, V5, P21, DOI 10.1207/s15402010bsm0501_2
   Barnes M, 2004, AM J RESP CRIT CARE, V170, P656, DOI 10.1164/rccm.200311-1571OC
   Bell RC, 2009, PSYCHIAT SERV, V60, P1686, DOI 10.1176/ps.2009.60.12.1686
   BENSON KL, 1994, AMER P PR R, V13, P677
   Bergé D, 2008, PSYCHOSOMATICS, V49, P447, DOI 10.1176/appi.psy.49.5.447
   Bixler EO, 2005, J CLIN ENDOCR METAB, V90, P4510, DOI 10.1210/jc.2005-0035
   Bottlender R, 1999, EUR PSYCHIAT, V14, P352, DOI 10.1016/S0924-9338(99)00155-8
   Boufidis S, 2003, INT J PSYCHIAT MED, V33, P305, DOI 10.2190/GGN0-Y09A-QV4X-DBA0
   Bradley TD, 2009, LANCET, V373, P82, DOI 10.1016/S0140-6736(08)61622-0
   Caplehorn JRM, 1999, MED J AUSTRALIA, V170, P104, DOI 10.5694/j.1326-5377.1999.tb127675.x
   Chang CK, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019590
   Chen YH, 2013, J CLIN SLEEP MED, V9, P417, DOI 10.5664/jcsm.2652
   Chouinard S, 2004, SCHIZOPHRENIA BULL, V30, P957, DOI 10.1093/oxfordjournals.schbul.a007145
   Deldin PJ, 2006, SLEEP MED, V7, P131, DOI 10.1016/j.sleep.2005.06.005
   Douglas N, 2013, INTERN MED J, V43, P630, DOI 10.1111/imj.12108
   DRUMMER OH, 1992, AM J FOREN MED PATH, V13, P346, DOI 10.1097/00000433-199212000-00017
   Engleman HM, 2004, THORAX, V59, P618, DOI 10.1136/thx.2003.015867
   Enright PL, 1996, SLEEP, V19, P531, DOI 10.1093/sleep/19.7.531
   Evans DL, 2005, BIOL PSYCHIAT, V58, P175, DOI 10.1016/j.biopsych.2005.05.001
   Feldman JL, 2006, NAT REV NEUROSCI, V7, P232, DOI 10.1038/nrn1871
   Ferrarelli F, 2007, AM J PSYCHIAT, V164, P483, DOI 10.1176/appi.ajp.164.3.483
   Ferrarelli F, 2010, AM J PSYCHIAT, V167, P1339, DOI 10.1176/appi.ajp.2010.09121731
   Freudenmann RW, 2008, PHARMACOPSYCHIATRY, V41, P119, DOI 10.1055/s-2008-1058111
   Gagnadoux F, 2014, CHEST
   Giles TL, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001106.pub2
   Habukawa M, 2010, SLEEP MED, V11, P552, DOI 10.1016/j.sleep.2010.02.007
   Haensel A, 2007, SLEEP BREATH, V11, P239, DOI 10.1007/s11325-007-0115-0
   Haque MF, 2008, J SLEEP RES, V17, P150
   Harris M, 2009, SLEEP MED REV, V13, P437, DOI 10.1016/j.smrv.2009.04.001
   Harvey AG, 2008, AM J PSYCHIAT, V165, P820, DOI 10.1176/appi.ajp.2008.08010098
   Hennessy RJ, 2010, SCHIZOPHR RES, V122, P63, DOI 10.1016/j.schres.2010.05.001
   Hoyt BD, 2005, PRIMARY CARE, V32, P535, DOI 10.1016/j.pop.2005.02.013
   Irwin MR, 2007, BRAIN BEHAV IMMUN, V21, P374, DOI 10.1016/j.bbi.2007.01.010
   Jordan AS, 2014, LANCET, V383, P736, DOI 10.1016/S0140-6736(13)60734-5
   KALES A, 1985, J CHRON DIS, V38, P427, DOI 10.1016/0021-9681(85)90138-9
   Kalucy MJ, 2013, SLEEP MED REV, V17, P357, DOI 10.1016/j.smrv.2012.10.003
   Karanti A, 2007, PSYCHOPHARMACOL BULL, V40, P113
   Katon W, 2007, GEN HOSP PSYCHIAT, V29, P147, DOI 10.1016/j.genhosppsych.2006.11.005
   Katon WJ, 2003, BIOL PSYCHIAT, V54, P216, DOI 10.1016/S0006-3223(03)00273-7
   Kelly T, 2013, J AFFECT DISORDERS, V151, P54, DOI 10.1016/j.jad.2013.05.047
   Kjelsberg FN, 2005, SLEEP MED, V6, P341, DOI 10.1016/j.sleep.2005.02.004
   Lalley PM, 2009, AM J PHYSIOL-REG I, V296, pR1829, DOI 10.1152/ajpregu.00057.2009
   Lambert TJ, 2010, ADV BIOL PSYCH-KARG, V26, P87
   Lambert TJR, 2009, MED J AUSTRALIA, V190, pS39
   Laursen TM, 2014, ANNU REV CLIN PSYCHO, V10, P425, DOI 10.1146/annurev-clinpsy-032813-153657
   Law M, 2014, J CLIN SLEEP MED
   Lee IS, 2012, SLEEP MED, V13, P161, DOI 10.1016/j.sleep.2011.09.005
   LEE S, 1989, AUST NZ J PSYCHIAT, V23, P571, DOI 10.3109/00048678909062627
   Li CT, 2014, SLEEP, V37, P803, DOI 10.5665/sleep.3594
   Lindberg E, 2001, AM J RESP CRIT CARE, V164, P2031, DOI 10.1164/ajrccm.164.11.2102028
   Manoach DS, 2010, J PSYCHIATR RES, V44, P112, DOI 10.1016/j.jpsychires.2009.06.011
   Marin JM, 2005, LANCET, V365, P1046, DOI 10.1016/S0140-6736(05)71141-7
   Marshall NS, 2008, SLEEP, V31, P1079
   Marshall NS, 2005, THORAX, V60, P427, DOI 10.1136/thx.2004.032078
   MARTIN PR, 1981, CAN MED ASSOC J, V124, P978
   McCall WV, 2006, J CLIN SLEEP MED, V2, P424
   McCann UD, 2009, NEUROLOGY, V73, P2011, DOI 10.1212/WNL.0b013e3181c51a62
   Merikangas KR, 2011, ARCH GEN PSYCHIAT, V68, P241, DOI 10.1001/archgenpsychiatry.2011.12
   Meyer JM, 2009, ACTA PSYCHIAT SCAND, V119, P4, DOI 10.1111/j.1600-0447.2008.01317.x
   Naismith SL, 2005, J CLIN SLEEP MED, V1, P374
   Ohayon MM, 2003, J CLIN PSYCHIAT, V64, P1195, DOI 10.4088/JCP.v64n1009
   Parks J., 2006, Morbidity and mortality in people with serious mental illness
   Peppard PE, 2006, ARCH INTERN MED, V166, P1709, DOI 10.1001/archinte.166.16.1709
   Phillips CL, 2013, AM J RESP CRIT CARE, V187, P879, DOI 10.1164/rccm.201212-2223OC
   Povitz M, 2014, EFFECT TREATME UNPUB
   REYNOLDS CF, 1984, J CLIN PSYCHIAT, V45, P287
   Rishi MA, 2010, CLIN NEUROPHARMACOL, V33, P109, DOI 10.1097/WNF.0b013e3181db8040
   Roshanaei-Moghaddam B, 2009, PSYCHIAT SERV, V60, P147, DOI 10.1176/appi.ps.60.2.147
   Sassani A, 2004, SLEEP, V27, P453, DOI 10.1093/sleep/27.3.453
   Sforza E, 2002, SLEEP MED, V3, P139, DOI 10.1016/S1389-9457(01)00128-9
   Sharafkhaneh A, 2005, SLEEP, V28, P1405, DOI 10.1093/sleep/28.11.1405
   Shepertycky MR, 2005, SLEEP, V28, P309
   Takahashi K, 1998, PSYCHIAT CLIN NEUROS, V52, P229, DOI 10.1111/j.1440-1819.1998.tb01046.x
   Teichtahl H, 2005, CHEST, V128, P1339, DOI 10.1378/chest.128.3.1339
   Trakada G, 2008, PSYCHOPHARMACOL BULL, V41, P89
   van Winkel R, 2008, BIPOLAR DISORD, V10, P342, DOI 10.1111/j.1399-5618.2007.00520.x
   Vgontzas AN, 2000, J CLIN ENDOCR METAB, V85, P1151, DOI 10.1210/jc.85.3.1151
   Walker JM, 2007, J CLIN SLEEP MED, V3, P455
   Wang D, 2005, CHEST, V128, P1348, DOI 10.1378/chest.128.3.1348
   Wang D, 2007, SLEEP MED REV, V11, P35, DOI 10.1016/j.smrv.2006.03.006
   Wang D, 2014, SLEEP BREATH, V18, P229, DOI 10.1007/s11325-013-0901-9
   WARD SLD, 1986, AM J DIS CHILD, V140, P1015, DOI 10.1001/archpedi.1986.02140240061028
   WARD SLD, 1990, J PEDIATR-US, V117, P876
   Waters F, 2013, SCHIZOPHR RES, V143, P393, DOI 10.1016/j.schres.2012.11.034
   Wheaton AG, 2012, SLEEP, V35, P461, DOI 10.5665/sleep.1724
   Winkelman JW, 2001, J CLIN PSYCHIAT, V62, P8, DOI 10.4088/JCP.v62n0103
   Wirshing DA, 2002, J CLIN PSYCHIAT, V63, P369, DOI 10.4088/JCP.v63n0415f
   Wulff K, 2012, BRIT J PSYCHIAT, V200, P308, DOI 10.1192/bjp.bp.111.096321
   YOUNG T, 1993, NEW ENGL J MED, V328, P1230, DOI 10.1056/NEJM199304293281704
NR 97
TC 22
Z9 26
U1 1
U2 35
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1523-3812
EI 1535-1645
J9 CURR PSYCHIAT REP
JI Curr. Psychiatry Rep.
PD DEC
PY 2014
VL 16
IS 12
AR 519
DI 10.1007/s11920-014-0519-z
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AR9KX
UT WOS:000343893600006
PM 25308389
DA 2025-06-11
ER

PT J
AU Hsu, NW
   Chou, KC
   Wang, YTT
   Hung, CL
   Kuo, CF
   Tsai, SY
AF Hsu, Nai-Wei
   Chou, Kai-Chen
   Wang, Yu-Ting Tina
   Hung, Chung-Lieh
   Kuo, Chien-Feng
   Tsai, Shin-Yi
TI Building a model for predicting metabolic syndrome using artificial
   intelligence based on an investigation of whole-genome sequencing
SO JOURNAL OF TRANSLATIONAL MEDICINE
LA English
DT Article
DE Circadian rhythm; Metabolic syndrome; Whole-genome sequencing; Deep
   learning
ID CIRCADIAN-RHYTHMS; OXIDATIVE STRESS; POPULATION; GENES; SLEEP; RISK;
   RORA
AB Background The circadian system is responsible for regulating various physiological activities and behaviors and has been gaining recognition. The circadian rhythm is adjusted in a 24-h cycle and has transcriptional-translational feedback loops. When the circadian rhythm is interrupted, affecting the expression of circadian genes, the phenotypes of diseases could amplify. For example, the importance of maintaining the internal temporal homeostasis conferred by the circadian system is revealed as mutations in genes coding for core components of the clock result in diseases. This study will investigate the association between circadian genes and metabolic syndromes in a Taiwanese population. Methods We performed analysis using whole-genome sequencing, read vcf files and set target circadian genes to determine if there were variants on target genes. In this study, we have investigated genetic contribution of circadian-related diseases using population-based next generation whole genome sequencing. We also used significant SNPs to create a metabolic syndrome prediction model. Logistic regression, random forest, adaboost, and neural network were used to predict metabolic syndrome. In addition, we used random forest model variables importance matrix to select 40 more significant SNPs, which were subsequently incorporated to create new prediction models and to compare with previous models. The data was then utilized for training set and testing set using five-fold cross validation. Each model was evaluated with the following criteria: area under the receiver operating characteristics curve (AUC), precision, F1 score, and average precision (the area under the precision recall curve). Results After searching significant variants, we used Chi-Square tests to find some variants. We found 186 significant SNPs, and four predicting models which used 186 SNPs (logistic regression, random forest, adaboost and neural network), AUC were 0.68, 0.8, 0.82, 0.81 respectively. The F1 scores were 0.412, 0.078, 0.295, 0.552, respectively. The other three models which used the 40 SNPs (logistic regression, adaboost and neural network), AUC were 0.82, 0.81, 0.81 respectively. The F1 scores were 0.584, 0.395, 0.574, respectively. Conclusions Circadian gene defect may also contribute to metabolic syndrome. Our study found several related genes and building a simple model to predict metabolic syndrome.
C1 [Hsu, Nai-Wei; Hung, Chung-Lieh; Kuo, Chien-Feng; Tsai, Shin-Yi] Mackay Med Coll, Dept Med, New Taipei, Taiwan.
   [Chou, Kai-Chen; Wang, Yu-Ting Tina; Tsai, Shin-Yi] MacKay Mem Hosp, Dept Lab Med, Taipei, Taiwan.
   [Kuo, Chien-Feng] MacKay Jr Coll Med Nursing & Management, Dept Nursing, New Taipei, Taiwan.
   [Kuo, Chien-Feng] Mackay Mem Hosp, Dept Internal Med, Div Infect Dis, Taipei, Taiwan.
   [Tsai, Shin-Yi] Johns Hopkins Univ, Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, Baltimore, MD 21205 USA.
   [Hung, Chung-Lieh; Tsai, Shin-Yi] Mackay Med Coll, Inst Biomed Sci, New Taipei, Taiwan.
   [Tsai, Shin-Yi] Mackay Med Coll, Inst Long Term Care, New Taipei, Taiwan.
C3 Mackay Medical College; Mackay Memorial Hospital; Mackay Junior College
   of Medicine, Nursing & Management; Mackay Memorial Hospital; Johns
   Hopkins University; Johns Hopkins Bloomberg School of Public Health;
   Mackay Medical College; Mackay Medical College
RP Tsai, SY (corresponding author), Mackay Med Coll, Dept Med, New Taipei, Taiwan.; Tsai, SY (corresponding author), MacKay Mem Hosp, Dept Lab Med, Taipei, Taiwan.; Tsai, SY (corresponding author), Johns Hopkins Univ, Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, Baltimore, MD 21205 USA.; Tsai, SY (corresponding author), Mackay Med Coll, Inst Biomed Sci, New Taipei, Taiwan.; Tsai, SY (corresponding author), Mackay Med Coll, Inst Long Term Care, New Taipei, Taiwan.
EM stsai22@jhu.edu
RI huang, wenyu/HTQ-5747-2023; Tsai, Shin-Yi/AAQ-7649-2020
OI Tsai, Shin-Yi/0000-0001-7978-778X
FU Department of Medical Research at Mackay Memorial Hospital, Taiwan
   [MMH-106-81, MMH-107-71, MMH107-102, MMH-107-135, MMH-109-79,
   MMH-109-103]; Mackay Medical College [1082A03]; Department of Medical
   Research at Mackay Memorial Hospital
FX This study was supported by the Department of Medical Research at Mackay
   Memorial Hospital, Taiwan, Grant Numbers MMH-106-81, MMH-107-71,
   MMH107-102, MMH-107-135, MMH-109-79, MMH-109-103, and Mackay Medical
   College, Grant Number 1082A03. The APC was funded by the Department of
   Medical Research at Mackay Memorial Hospital and both of the co-first
   and the corresponding author: Dr. Chien-Feng Kuo and Dr. Shin-Yi Tsai.
CR Ahmadian E, 2016, EXPERT REV GASTROENT, V10, P1279, DOI 10.1080/17474124.2016.1207523
   Akcoltekin A, 2017, EURASIAN J EDUC RES, P19, DOI [10.1007/978-3-319-48382-5_2, 10.14689/ejer.2017.68.2]
   Beltrán-Sánchez H, 2013, J AM COLL CARDIOL, V62, P697, DOI 10.1016/j.jacc.2013.05.064
   Billon C, 2017, FRONT ENDOCRINOL, V8, DOI 10.3389/fendo.2017.00141
   Burns Trudy L, 2009, J Pediatr, V155, DOI 10.1016/j.jpeds.2009.04.044
   Chaix A, 2019, CELL METAB, V29, P303, DOI 10.1016/j.cmet.2018.08.004
   Chalfant JM, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-66834-9
   Chen CH, 2016, HUM MOL GENET, V25, P5321, DOI 10.1093/hmg/ddw346
   Chen ZL, 2021, J PSYCHIATR RES, V132, P123, DOI 10.1016/j.jpsychires.2020.09.037
   Cherukalady R, 2017, BIOL RHYTHM RES, V48, P583, DOI 10.1080/09291016.2017.1287820
   Choe Eun Kyung, 2018, Genomics & Informatics, V16, pe31
   Cox KH, 2019, J MOL ENDOCRINOL, V63, pR93, DOI 10.1530/JME-19-0153
   Cugini P, 2004, Clin Ter, V155, P287
   Cui P, 2018, BBA-MOL BASIS DIS, V1864, P2274, DOI 10.1016/j.bbadis.2017.12.004
   Eftekhari A, 2016, TOXICOL MECH METHOD, V26, P520, DOI 10.1080/15376516.2016.1204641
   Gaudillo J, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0225574
   Geoffroy PA, 2016, GENES BRAIN BEHAV, V15, P660, DOI 10.1111/gbb.12306
   Guan DY, 2021, J CLIN INVEST, V131, DOI 10.1172/JCI148278
   Guo Z, 2019, MOL MED REP, V19, P4271, DOI 10.3892/mmr.2019.10067
   Gurung R, 2017, GENETICS, V205, P725, DOI 10.1534/genetics.116.192864
   Hou SJ, 2020, SLEEP MED, V73, P70, DOI 10.1016/j.sleep.2020.04.008
   Hyun MH, 2020, CARDIOVASC THER, V2020, DOI 10.1155/2020/4354759
   Jagannath A, 2017, HUM MOL GENET, V26, pR128, DOI 10.1093/hmg/ddx240
   Kohashi K, 2017, CANCER SCI, V108, P547, DOI 10.1111/cas.13173
   Lazado CC, 2014, MAR GENOM, V18, P21, DOI 10.1016/j.margen.2014.04.011
   Li H, 2008, GENOME RES, V18, P1851, DOI 10.1101/gr.078212.108
   Lin E, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0173861
   Liu ZH, 2005, MOL CANCER RES, V3, P21
   Maiese K, 2021, BIOMOLECULES, V11, DOI 10.3390/biom11071002
   Malfatti Edoardo, 2015, J Neuromuscul Dis, V2, P219
   Malik VS, 2010, DIABETES CARE, V33, P2477, DOI 10.2337/dc10-1079
   Izquierdo-Palomares JM, 2016, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009462.pub2
   Meydan C, 2018, FRONT MOL NEUROSCI, V11, DOI 10.3389/fnmol.2018.00189
   Narain A, 2017, INT J CLIN PRACT, V71, DOI 10.1111/ijcp.12927
   Pavlova Milena, 2017, Continuum (Minneap Minn), V23, P1051, DOI 10.1212/CON.0000000000000499
   PITTENDRIGH CS, 1976, J COMP PHYSIOL, V106, P291, DOI 10.1007/BF01417859
   Powell WT, 2013, HUM MOL GENET, V22, P4318, DOI 10.1093/hmg/ddt281
   Ranasinghe P, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4041-1
   Rao SK, 2010, J BIOL CHEM, V285, P32512, DOI 10.1074/jbc.M110.150490
   Salamon M, 2003, J MOL BIOL, V326, P137, DOI 10.1016/S0022-2836(02)01335-9
   Samson SL, 2014, ENDOCRIN METAB CLIN, V43, P1, DOI 10.1016/j.ecl.2013.09.009
   Schilperoort M, 2020, J PINEAL RES, V68, DOI 10.1111/jpi.12614
   Schober A, 2021, CIRCULATION, V144, P1059, DOI 10.1161/CIRCULATIONAHA.120.051614
   Solovyeva I A, 2016, Genetika, V52, P393
   Sui J, 2016, INT J ONCOL, V49, P2023, DOI 10.3892/ijo.2016.3716
   Sun K, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047791
   Tanner RM, 2012, CURR HYPERTENS REP, V14, P152, DOI 10.1007/s11906-012-0254-y
   Tsai SY, 2019, J TRANSL MED, V17, DOI 10.1186/s12967-019-1797-3
   Tsuchiya Y, 2020, INT J UROL, V27, P518, DOI 10.1111/iju.14231
   Wang H, 2020, J CELL MOL MED, V24, P1399, DOI 10.1111/jcmm.14818
   Wilking M, 2013, ANTIOXID REDOX SIGN, V19, P192, DOI 10.1089/ars.2012.4889
   Yang TY, 2022, J TRANSL MED, V20, DOI 10.1186/s12967-022-03301-1
   Zhai JM, 2018, ONCOL LETT, V15, P5819, DOI 10.3892/ol.2018.8060
   Zhang XQ, 2008, INT J MOL MED, V22, P149, DOI 10.3892/ijmm_00000002
NR 54
TC 12
Z9 12
U1 0
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1479-5876
J9 J TRANSL MED
JI J. Transl. Med.
PD APR 28
PY 2022
VL 20
IS 1
AR 190
DI 10.1186/s12967-022-03379-7
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 0V8LR
UT WOS:000788592100003
PM 35484552
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Geurts, L
   Everard, A
   le Ruyet, P
   Delzenne, NM
   Cani, PD
AF Geurts, Lucie
   Everard, Amandine
   le Ruyet, Pascale
   Delzenne, Nathalie M.
   Cani, Patrice D.
TI Ripened Dairy Products Differentially Affect Hepatic Lipid Content and
   Adipose Tissue Oxidative Stress Markers in Obese and Type 2 Diabetic
   Mice
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE glucose tolerance; hepatic steatosis; type 2 diabetes; cheese; oxidative
   stress
ID HIGH-FAT DIET; INSULIN-RESISTANCE SYNDROME; GUT MICROBIOTA; SOYBEAN
   LECITHIN; INFLAMMATION; CONSUMPTION; STEATOSIS; HYPERGLYCEMIA;
   PATHOGENESIS; METABOLISM
AB Growing evidence suggests that the consumption of dairy products may contribute to a reduced incidence of cardiovascular risk factors, such as obesity, dyslipidemia, and type 2 diabetes. The fatty acid composition in milk fat, the duration of ripening, and the complexity of the food matrices are important factors that may interfere with the physiological impact. In this study, we treated genetic obese and type 2 diabetic mice (db/db) for 4 weeks with different dairy (cheese-based) products, differing by the duration of ripening (0, 15, or 35 days). We found that 35 days ripened product significantly improved glucose tolerance, an effect associated with a decreased adipose tissue lipid peroxide markers (TBARS and NAPDH-oxidase mRNA expression), without affecting body weight, food intake, and fat mass. Both fermented matrices significantly decreased the hepatic lipid content, without modifying plasma triglycerides or plasma total cholesterol. These data suggest that dairy products issued from longer ripening positively impact glucose tolerance, hepatic steatosis, and adipose tissue oxidative stress. Further investigations are warranted to decipher the interactions between milk products fermentation, lipids, and host metabolism.
C1 [Geurts, Lucie; Everard, Amandine; Delzenne, Nathalie M.; Cani, Patrice D.] Catholic Univ Louvain, Louvain Drug Res Inst, Metab & Nutr Res Grp, B-1200 Brussels, Belgium.
   [le Ruyet, Pascale] Lactalis, RetD Lactalis, Laval, France.
C3 Universite Catholique Louvain
RP Cani, PD (corresponding author), Catholic Univ Louvain, Louvain Drug Res Inst, Metab & Nutr Res Grp, Av E Mounier 73,Box B1-73-11, B-1200 Brussels, Belgium.
EM patrice.cani@uclouvain.be
RI Delzenne, Nathalie/AAC-4628-2019; Cani, Patrice D./M-8055-2016
OI Cani, Patrice D./0000-0003-2040-2448; Delzenne,
   Nathalie/0000-0003-2115-6082; Everard, Amandine/0000-0001-8925-8144
FU FSR; FRSM; Lactalis
FX N.M.D. and P.D.C. are recipients of FSR and FRSM grants (Fonds speciaux
   de recherches, UCL, Belgium; Fonds de la recherche scientifique
   medicale, Belgium).The authors declare the following competing financial
   interest(s): This study was supported in part by Lactalis.
CR Acheson KJ, 2011, AM J CLIN NUTR, V93, P525, DOI 10.3945/ajcn.110.005850
   Bäckhed F, 2010, BBA-MOL CELL BIOL L, V1801, P240, DOI 10.1016/j.bbalip.2009.09.009
   Bertoni G, 2001, P NUTR SOC, V60, P231, DOI 10.1079/PNS200080
   Brun P, 2007, AM J PHYSIOL-GASTR L, V292, pG518, DOI 10.1152/ajpgi.00024.2006
   Callon C, 2005, J DAIRY SCI, V88, P3840, DOI 10.3168/jds.S0022-0302(05)73069-1
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Choi HK, 2005, ARCH INTERN MED, V165, P997, DOI 10.1001/archinte.165.9.997
   Dandona P, 2004, TRENDS IMMUNOL, V25, P4, DOI 10.1016/j.it.2003.10.013
   Dewulf EM, 2011, J NUTR BIOCHEM, V22, P712, DOI 10.1016/j.jnutbio.2010.05.009
   Duparc T, 2011, ANTIOXID REDOX SIGN, V14, P415, DOI 10.1089/ars.2010.3330
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   Frid AH, 2005, AM J CLIN NUTR, V82, P69, DOI 10.1093/ajcn/82.1.69
   Fumeron F, 2011, DIABETES CARE, V34, P813, DOI 10.2337/dc10-1772
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gentile CL, 2008, J NUTR BIOCHEM, V19, P567, DOI 10.1016/j.jnutbio.2007.10.001
   Geurts L, 2011, FRONT MICROBIOL, V2, DOI 10.3389/fmicb.2011.00149
   Guessous I, 2011, KIDNEY BLOOD PRESS R, V34, P404, DOI 10.1159/000328332
   LeBlanc MJ, 2003, J NUTR BIOCHEM, V14, P40, DOI 10.1016/S0955-2863(02)00253-X
   Levy JR, 2002, AM J PHYSIOL-ENDOC M, V282, pE626, DOI 10.1152/ajpendo.00346.2001
   Neyrinck AM, 2012, J NUTR BIOCHEM, V23, P51, DOI 10.1016/j.jnutbio.2010.10.008
   Neyrinck AM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020944
   Nilsson M, 2004, AM J CLIN NUTR, V80, P1246, DOI 10.1093/ajcn/80.5.1246
   Pachikian B. D., 2008, BMC Physiology, V8, P21, DOI 10.1186/1472-6793-8-21
   Pereira MA, 2002, JAMA-J AM MED ASSOC, V287, P2081, DOI 10.1001/jama.287.16.2081
   Petersen KF, 2005, DIABETES, V54, P603, DOI 10.2337/diabetes.54.3.603
   Polichetti E, 1996, BRIT J NUTR, V75, P471, DOI 10.1079/BJN19960148
   Rebolledo OR, 2008, HORM METAB RES, V40, P794, DOI 10.1055/s-2008-1081502
   Roden M, 2006, NAT CLIN PRACT ENDOC, V2, P335, DOI 10.1038/ncpendmet0190
   Samuel VT, 2010, LANCET, V375, P2267, DOI 10.1016/S0140-6736(10)60408-4
   Sohet FM, 2009, BIOCHEM PHARMACOL, V78, P1391, DOI 10.1016/j.bcp.2009.07.008
   Sohet FM, 2009, BRIT J NUTR, V102, P462, DOI 10.1017/S0007114508191243
   Stefan N, 2011, DIABETOLOGIA, V54, P7, DOI 10.1007/s00125-010-1938-y
   Wat E, 2009, ATHEROSCLEROSIS, V205, P144, DOI 10.1016/j.atherosclerosis.2008.12.004
   Yecies JL, 2011, CELL METAB, V14, P21, DOI 10.1016/j.cmet.2011.06.002
NR 36
TC 24
Z9 26
U1 0
U2 16
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD FEB 29
PY 2012
VL 60
IS 8
BP 2063
EP 2068
DI 10.1021/jf204916x
PG 6
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA 899ZI
UT WOS:000300854900022
PM 22300436
DA 2025-06-11
ER

PT J
AU Sha, H
   Zeng, HR
   Zhao, J
   Jin, HY
AF Sha, Han
   Zeng, Huirong
   Zhao, Jie
   Jin, Haiying
TI Mangiferin ameliorates gestational diabetes mellitus-induced placental
   oxidative stress, inflammation and endoplasmic reticulum stress and
   improves fetal outcomes in mice
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Mangiferin; Gestational diabetes mellitus; Oxidative stress;
   Inflammation; Endoplasmic reticulum stress
ID BETA-CELL FUNCTION; INSULIN-RESISTANCE; METABOLIC SYNDROME; MODEL;
   PREGNANCY; GLUCOSE
AB Gestational diabetes mellitus (GDM) is a temporary form of diabetes during pregnancy, which causes maternal diabetic symptoms and abnormal fetal development, and influence the health of maternal-child in clinical practice. Mangiferin is a bioactive ingredient with anti-inflammation, anti-oxidation and anti-endoplasmic reticulum stress activities. In current study, the effects of mangiferin on GDM were evaluated. We reported that mangiferin greatly improved altered glucose and lipid profile, insulin tolerance, and reproductive outcomes of the GDM mice. Mangiferin ameliorated placental oxidative stress, inflammation and ER stress in GDM mice. Therefore, we demonstrated that mangiferin displayed protective effects on gestational diabetes mellitus symptoms by suppressing placental oxidative stress, inflammation and endoplasmic reticulum stress in GDM mice.
C1 [Sha, Han; Zeng, Huirong; Zhao, Jie; Jin, Haiying] Heze Municipal Hosp, Dept Obstet & Gynecol, 2888 Caozhou Rd, Heze 274000, Shandong, Peoples R China.
RP Jin, HY (corresponding author), Heze Municipal Hosp, Dept Obstet & Gynecol, 2888 Caozhou Rd, Heze 274000, Shandong, Peoples R China.
EM jinhaiying2020@163.com
CR Ables GP, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051357
   Brustman LE, 2016, J MATERN-FETAL NEO M, V29, P1025, DOI 10.3109/14767058.2015.1034101
   Burton Jeffrey H, 2015, J Diabetes Sci Technol, V9, P808, DOI 10.1177/1932296815577425
   Das J, 2012, TOXICOL APPL PHARM, V260, P35, DOI 10.1016/j.taap.2012.01.015
   Dou W, 2014, INT IMMUNOPHARMACOL, V23, P170, DOI 10.1016/j.intimp.2014.08.025
   ERIKSSON UJ, 1991, DIABETOLOGIA, V34, P325, DOI 10.1007/BF00405004
   Feig DS, 2011, DIABETES CARE, V34, P2329, DOI 10.2337/dc11-1153
   Fraulob JC, 2010, J CLIN BIOCHEM NUTR, V46, P212, DOI 10.3164/jcbn.09-83
   Gardosi J, 2009, AM J OBSTET GYNECOL, V201, DOI 10.1016/j.ajog.2009.04.035
   Gold-Smith F, 2016, NUTRIENTS, V8, DOI 10.3390/nu8070396
   Gong X, 2013, J NUTR BIOCHEM, V24, P1173, DOI 10.1016/j.jnutbio.2012.09.003
   Greenberg AS, 2002, EUR J CLIN INVEST, V32, P24, DOI 10.1046/j.1365-2362.32.s3.4.x
   KAUFMANN RC, 1981, AM J OBSTET GYNECOL, V141, P479, DOI 10.1016/S0002-9378(15)33263-4
   Kleiblova P, 2010, MOL CELL ENDOCRINOL, V314, P150, DOI 10.1016/j.mce.2009.08.002
   Klein K, 2008, PRENATAL DIAG, V28, P845, DOI 10.1002/pd.2064
   Langer O, 2013, OBSTET GYNECOL, V121, P177, DOI [http://10.1097/AOG.0b013e31827711e5, 10.1097/AOG.0b013e31827711e5]
   Lappas M, 2011, ANTIOXID REDOX SIGN, V15, P3061, DOI 10.1089/ars.2010.3765
   Lee AS, 2005, METHODS, V35, P373, DOI 10.1016/j.ymeth.2004.10.010
   Márquez L, 2012, EUR J NUTR, V51, P729, DOI 10.1007/s00394-011-0252-x
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McKeown NM, 2004, DIABETES CARE, V27, P538, DOI 10.2337/diacare.27.2.538
   Nansseu JRN, 2016, SYST REV-LONDON, V5, DOI 10.1186/s13643-016-0369-3
   Reece EA, 2009, LANCET, V373, P1789, DOI 10.1016/S0140-6736(09)60515-8
   Roca-Rodriguez M. M., 2014, J ENDOCRINOL
   Ryckman KK, 2015, BJOG-INT J OBSTET GY, V122, P643, DOI 10.1111/1471-0528.13261
   Sellamuthu Periyar Selvam, 2013, ISRN Pharmacol, V2013, P750109, DOI 10.1155/2013/750109
   Singh B, 2010, WORLD J DIABETES, V1, P36, DOI 10.4239/wjd.v1.i2.36
   Sudharshana Murthy K A, 2018, Indian J Endocrinol Metab, V22, P79, DOI 10.4103/ijem.IJEM_232_16
   Xu XS, 2018, EUR J NUTR, V57, P1563, DOI 10.1007/s00394-017-1441-z
   Yung HW, 2016, DIABETOLOGIA, V59, P2240, DOI 10.1007/s00125-016-4040-2
   ZHENG MS, 1990, CHINESE MED J-PEKING, V103, P160
   Zou CL, 2018, J PHARMACOL SCI, V138, P161, DOI 10.1016/j.jphs.2018.09.008
NR 32
TC 34
Z9 38
U1 1
U2 48
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD SEP 15
PY 2019
VL 859
AR 172522
DI 10.1016/j.ejphar.2019.172522
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IM2JT
UT WOS:000477819500015
PM 31276667
DA 2025-06-11
ER

PT J
AU Nunes, SOV
   de Melo, LGP
   de Castro, MRP
   Barbosa, DS
   Vargas, HO
   Berk, M
   Maes, M
AF Vargas Nunes, Sandra Odebrecht
   Piccoli de Melo, Luiz Gustavo
   Pizzo de Castro, Marcia Regina
   Barbosa, Decio Sabbatini
   Vargas, Heber Odebrecht
   Berk, Michael
   Maes, Michael
TI Atherogenic index of plasma and atherogenic coefficient are increased in
   major depression and bipolar disorder, especially when comorbid with
   tobacco use disorder
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Cardiovascular disease; Tobacco use disorder; Metabolic
   syndrome; Castelli risk index
ID CORONARY-HEART-DISEASE; DENSITY-LIPOPROTEIN CHOLESTEROL;
   CARDIOVASCULAR-DISEASE; INFLAMMATORY MARKERS; SMOKING-CESSATION;
   OXIDATIVE STRESS; HEALTH BEHAVIORS; RISK; SEX; OUTPATIENTS
AB Background: There is a robust comorbidify between mood cl sorclers and cardiovascular disorder (CVD). The atherogenic index of plasma (ALP) and the atherogenic coefficient (AC) are important atherogenic indexes. The aims of this study were to delineate whether AIP and AC are increased in mood disorders especially when comorbid with tobacco use disorder (TUD).
   Methods: In this case control study we included 134 patients with mood disorders, bipolar disorder and unipolar depression (cases), and 197 individuals without mood disorder (controls) divided into those with and without TUD (defined as never smokers), Total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDLc) and low density lipoprotein cholesterol (LDLc) were measured. RIP and AC were computed as log (TG/HDLc) and non-HDLc/HDLc, respectively.
   Results: The AIP and AC indexes were significantly increased in patients with mood disorders versus conirols, both in depression and bipolar disorder. PaLienis with mood disorder wiLhoui TUD and paLienis with TUD without mood disorder showed higher ALP and AC values than never smokers while those with comorbid mood disorders and TUD showed significanily higher ALP and AC levels Lhan all other individuals. A large parL of the variance in Lhe AlC (26.4%) and AC (204%) was explained by mood disorders, TUD, male gender and body mass index.
   Conclusions: The findings suggest that lipid abnormalifics leading Lo an increased aiherogenic poLenLial are involved in the pathophysiology of mood disorders (depression and bipolar disorder) and especially comorbid mood disorder and TUD. The comorbidity between mood disorders and CVD may be partly explained increased through AIP and AC indexes, impacting increments in atherogenic potential. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Vargas Nunes, Sandra Odebrecht; Vargas, Heber Odebrecht] Univ Estadual Londrina, Univ Hosp, Hlth Sci Ctr, Dept Clin Med,Psychiat Unit, Londrina, Brazil.
   [Vargas Nunes, Sandra Odebrecht; Piccoli de Melo, Luiz Gustavo; Pizzo de Castro, Marcia Regina; Vargas, Heber Odebrecht] Univ Estadual Londrina, Univ Hosp, Ctr Approach & Treatment Smokers, Londrina, Brazil.
   [Barbosa, Decio Sabbatini] Univ Estadual Londrina, Dept Clin Anal & Toxicol, Londrina, Parana, Brazil.
   [Berk, Michael; Maes, Michael] Deakin Univ, Impact Strateg Res Ctr, Geelong, Vic 3217, Australia.
   [Berk, Michael] Florey Inst Neurosci & Mental Hlth, Orygen Youth Hlth Res Ctr, Parkville, Vic 3052, Australia.
   [Berk, Michael] Florey Inst Neurosci & Mental Hlth, Ctr Youth Mental Hlth, Parkville, Vic 3052, Australia.
   [Berk, Michael] Univ Melbourne, Dept Psychiat, Parkville, Vic 3052, Australia.
   [Vargas Nunes, Sandra Odebrecht; Piccoli de Melo, Luiz Gustavo; Pizzo de Castro, Marcia Regina; Barbosa, Decio Sabbatini; Vargas, Heber Odebrecht; Maes, Michael] Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok 10330, Thailand.
   [Maes, Michael] Univ Estadual Londrina, Hlth Sci Ctr, Hlth Sci Grad Program, Londrina, Brazil.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   Universidade Estadual de Londrina; Deakin University; Florey Institute
   of Neuroscience & Mental Health; Orygen, The National Centre of
   Excellence in Youth Mental Health; Florey Institute of Neuroscience &
   Mental Health; Orygen, The National Centre of Excellence in Youth Mental
   Health; University of Melbourne; Chulalongkorn University; Universidade
   Estadual de Londrina
RP Maes, M (corresponding author), Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok 10330, Thailand.
EM dr.michaelmaes@hotmail.com
RI Berk, Michael/AGH-9427-2022; de Melo, Luiz Gustavo Piccoli/C-2271-2018;
   Nunes, Sandra/B-4035-2019; Maes, Michael/B-8546-2011; Barbosa,
   Décio/AAE-6351-2019; Berk, Michael/M-7891-2013
OI Melo, Luiz Gustavo Piccoli de/0000-0002-1078-8044; Berk,
   Michael/0000-0002-5554-6946; Odebrecht Vargas Nunes,
   Sandra/0000-0003-4851-6121
FU Health Sciences Postgraduate Program [40002012046P0]; Ministry for
   Sciences and Technology of Brazil (CNPq) [404377/2013-3]; Brazilian
   Federal Agency for Support and Evaluation of Graduate Education (CAPES);
   NHMRC [1059660]; CNPq (Consent Nacional de Desenvolvimento Cientifico e
   Technologia)
FX This study is supported by the Health Sciences Postgraduate Program
   (Grant no 40002012046P0) at the State University of Londrina, Brazil;
   the Ministry for Sciences and Technology of Brazil (CNPq (Grant no
   404377/2013-3)), the Brazilian Federal Agency for Support and Evaluation
   of Graduate Education (CAPES).MB is supported by a NHMRC Senior
   Principal Research Fellowship 1059660.MM is supported by a CNPq (Consent
   Nacional de Desenvolvimento Cientifico e Technologia) PVE fellowship and
   the Health Sciences Graduate Program fellowship, Londrina State
   University (UEL).
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   American Psychiatric Association, 2000, spectrum disorders using the current DSM-IV-TR diagnostic, V4th, DOI 10.1176/dsm10.1176/appi.books.9780890420249.dsm-iv-tr
   Arumalla VK, 2011, J CLIN DIAGN RES, V5, P1352
   Batic-Mujanovic Olivera, 2006, Med Arh, V60, P90
   Berk M, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-74
   Bhagavath P., 2012, INT J A J I MED SCI, V1, P93
   Bhardwaj S., 2013, Int J Pharm Biol Sci, V3, P359
   Bortolasci CC, 2014, J AFFECT DISORDERS, V159, P23, DOI 10.1016/j.jad.2014.02.018
   Brehm A, 2004, CLIN CHEM, V50, P2316, DOI 10.1373/clinchem.2004.037556
   Campbell SC, 2008, ATHEROSCLEROSIS, V201, P225, DOI 10.1016/j.atherosclerosis.2008.04.046
   Carney RM, 2005, ARCH INTERN MED, V165, P1486, DOI 10.1001/archinte.165.13.1486
   Davis CE, 1996, AM J EPIDEMIOL, V143, P1100
   Del-Ben Cristina Marta, 2001, Revista Brasileira de Psiquiatria, V23, P156, DOI 10.1590/S1516-44462001000300008
   DiMatteo MR, 2000, ARCH INTERN MED, V160, P2101, DOI 10.1001/archinte.160.14.2101
   Dobiasova M, 2000, Vnitr Lek, V46, P152
   Dobiásová M, 2001, CLIN BIOCHEM, V34, P583, DOI 10.1016/S0009-9120(01)00263-6
   Duivis HE, 2011, AM J PSYCHIAT, V168, P913, DOI 10.1176/appi.ajp.2011.10081163
   Forey BA, 2013, BIOMARK RES, V1, DOI 10.1186/2050-7771-1-26
   Frasure-Smith N, 2004, BIOL PSYCHIAT, V55, P891, DOI 10.1016/j.biopsych.2004.01.021
   Fruchart J. C., 2004, CIRCULATION S1, V15109, pS15
   Gehi A, 2005, ARCH INTERN MED, V165, P2508, DOI 10.1001/archinte.165.21.2508
   Halaris A, 2013, CURR PSYCHIAT REP, V15, DOI 10.1007/s11920-013-0400-5
   Henrique I. F. S., 2004, J BRAZ MED ASS, V50, P1
   Jacka FN, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/1471-244X-14-132
   Kendler KS, 2009, ARCH GEN PSYCHIAT, V66, P857, DOI 10.1001/archgenpsychiatry.2009.94
   Lippi G, 2009, SEMIN THROMB HEMOST, V35, P325, DOI 10.1055/s-0029-1222611
   Lopez AD, 2006, LANCET, V367, P1747, DOI 10.1016/S0140-6736(06)68770-9
   Maarcher Ann, 2011, Morbidity and Mortality Weekly Report, V60, P1513
   Maes M, 2011, PROG NEURO-PSYCHOPH, V35, P769, DOI 10.1016/j.pnpbp.2010.06.008
   Millán J, 2009, VASC HEALTH RISK MAN, V5, P757
   Moreno R.A., 1998, Revista de Psiquiatria Clinica, V25, P262
   Musselman DL, 1998, ARCH GEN PSYCHIAT, V55, P580, DOI 10.1001/archpsyc.55.7.580
   O'Neil A, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-154
   Otte C, 2004, BIOL PSYCHIAT, V56, P241, DOI 10.1016/j.biopsych.2004.06.003
   Schins A, 2004, LIFE SCI, V76, P637, DOI 10.1016/j.lfs.2004.04.060
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Stafford L, 2011, J CLIN PSYCHIAT, V72, P1229, DOI 10.4088/JCP.09m05825blu
   Sun K, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047791
   THELLE DS, 1982, J EPIDEMIOL COMMUN H, V36, P243, DOI 10.1136/jech.36.4.243
   Vargas HO, 2014, LIFE SCI, V102, P65, DOI 10.1016/j.lfs.2014.02.033
   Vargas HO, 2013, NEUROSCI LETT, V544, P136, DOI 10.1016/j.neulet.2013.03.059
   Nunes SOV, 2013, ADDICT DISORD TREAT, V12, P158, DOI 10.1097/ADT.0b013e31827a63ff
   Nunes SOV, 2014, PSYCHIAT GENET, V24, P87, DOI 10.1097/YPG.0000000000000023
   Nunes SOV, 2013, NEUROSCI BIOBEHAV R, V37, P1336, DOI 10.1016/j.neubiorev.2013.04.014
   Nunes SOV, 2012, NICOTINE TOB RES, V14, P540, DOI 10.1093/ntr/ntr247
   Venkatesan A, 2006, Indian J Physiol Pharmacol, V50, P273
   Wang YM, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-187
   Weissglas-Volkov D, 2010, J LIPID RES, V51, P2032, DOI 10.1194/jlr.R004739
   Whooley MA, 2008, JAMA-J AM MED ASSOC, V300, P2379, DOI 10.1001/jama.2008.711
   Whooley MA, 2006, JAMA-J AM MED ASSOC, V295, P2874, DOI 10.1001/jama.295.24.2874
   Ziegelstein RC, 2000, ARCH INTERN MED, V160, P1818, DOI 10.1001/archinte.160.12.1818
NR 51
TC 72
Z9 74
U1 1
U2 15
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD FEB 1
PY 2015
VL 172
BP 55
EP 62
DI 10.1016/j.jad.2014.09.038
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA AX0LD
UT WOS:000346643000009
PM 25451396
DA 2025-06-11
ER

PT J
AU Smith, SR
   Bai, FL
   Charbonneau, C
   Janderová, L
   Argyropoulos, G
AF Smith, SR
   Bai, FL
   Charbonneau, C
   Janderová, L
   Argyropoulos, G
TI A promoter genotype and oxidative stress potentially link resistin to
   human insulin resistance
SO DIABETES
LA English
DT Article
ID ADIPOSE-TISSUE; ADIPOCYTE DIFFERENTIATION; 3T3-L1 ADIPOCYTES;
   GLUCOSE-TRANSPORT; OBESITY; EXPRESSION; GENE; FAT; ASSOCIATION;
   CAUCASIANS
AB Insulin resistance is a component of type 2 diabetes and often precedes pancreatic beta-cell failure. Contributing factors include obesity and a central pattern of fat accumulation with a strong genetic component. The adipocyte secreted hormone resistin has been proposed as a link between the adipocyte and insulin resistance by inhibition of insulin-stimulated glucose uptake and/or blocking adipocyte differentiation. Here we report that the G/G genotype of a single nucleotide polymorphism (SNP) in the promoter of the human resistin gene, -180C>G, had significantly increased basal promoter activity in adipocytes. These data were recapitulated in vivo, where G/G homozygotes had significantly higher resistin mRNA levels in human abdominal subcutaneous fat. A significant interaction was also found between the -180C>G SNP, a marker of oxidative stress (NAD[P]H quinone oxidoreductase mRNA) and homeostasis model assessment of insulin resistance. In addition, resistin mRNA was positively and independently correlated with insulin resistance and hepatic fat as measured by liver X-ray attenuation. These data implicate resistin in the pathophysiology of the human insulin resistance syndrome, an effect mediated by the -180C>G promoter SNP and potentially cellular oxidative stress.
C1 Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center
RP Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM smithsr@pbrc.edu; argyrog@pbre.edu
RI ; Rossmeislova, Lenka/D-1931-2013
OI Smith, Steven/0000-0002-5098-8147; Rossmeislova,
   Lenka/0000-0002-7611-7585
CR AMMENDOLA R, 1994, EUR J BIOCHEM, V225, P483, DOI 10.1111/j.1432-1033.1994.t01-1-00483.x
   Danforth E, 2000, NAT GENET, V26, P13, DOI 10.1038/79111
   Du XL, 2000, P NATL ACAD SCI USA, V97, P12222, DOI 10.1073/pnas.97.22.12222
   Engert JC, 2002, DIABETES, V51, P1629, DOI 10.2337/diabetes.51.5.1629
   Evans J L, 2000, Diabetes Technol Ther, V2, P401, DOI 10.1089/15209150050194279
   Evans JL, 2003, DIABETES, V52, P1, DOI 10.2337/diabetes.52.1.1
   Gaikwad A, 2001, J BIOL CHEM, V276, P22559, DOI 10.1074/jbc.M101053200
   Ghosh S, 2003, GENE, V305, P27, DOI 10.1016/S0378-1119(02)01213-1
   Hartman HB, 2002, J BIOL CHEM, V277, P19754, DOI 10.1074/jbc.M201451200
   Holcomb IN, 2000, EMBO J, V19, P4046, DOI 10.1093/emboj/19.15.4046
   Jaiswal AK, 2000, FREE RADICAL BIO MED, V29, P254, DOI 10.1016/S0891-5849(00)00306-3
   Jonke J, 2002, OBES RES, V10, P1
   Kern PA, 2002, TOXICOLOGY, V171, P117, DOI 10.1016/S0300-483X(01)00564-9
   Kim KM, 2001, J BIOL CHEM, V276, P37409, DOI 10.1074/jbc.M106728200
   Le Lay S, 2001, BIOCHEM BIOPH RES CO, V289, P564, DOI 10.1006/bbrc.2001.6015
   Ma XW, 2002, J CLIN ENDOCR METAB, V87, P4407, DOI 10.1210/jc.2002-020109
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mayfield DK, 2001, BIOCHEM BIOPH RES CO, V287, P568, DOI 10.1006/bbrc.2001.5600
   McTernan CL, 2002, LANCET, V359, P46, DOI 10.1016/S0140-6736(02)07281-1
   Morin N, 2001, J PHARMACOL EXP THER, V297, P563
   Nagaev I, 2001, BIOCHEM BIOPH RES CO, V285, P561, DOI 10.1006/bbrc.2001.5173
   Osawa H, 2002, DIABETES, V51, P863, DOI 10.2337/diabetes.51.3.863
   Pizzuti A, 2002, J CLIN ENDOCR METAB, V87, P4403, DOI 10.1210/jc.2002-020096
   Raha S, 2002, FREE RADICAL BIO MED, V32, P421, DOI 10.1016/S0891-5849(01)00816-4
   Rajala MW, 2002, MOL ENDOCRINOL, V16, P1920, DOI 10.1210/me.2002-0048
   Rudich A, 1997, AM J PHYSIOL-ENDOC M, V272, pE935, DOI 10.1152/ajpendo.1997.272.5.E935
   Rudich A, 1999, DIABETOLOGIA, V42, P949, DOI 10.1007/s001250051253
   Ryysy L, 2000, DIABETES, V49, P749, DOI 10.2337/diabetes.49.5.749
   Savage DB, 2001, DIABETES, V50, P2199, DOI 10.2337/diabetes.50.10.2199
   SCHUG J, CBILTR19971001V00 U
   Sentinelli F, 2002, DIABETES, V51, P860, DOI 10.2337/diabetes.51.3.860
   Smith SR, 2001, METABOLISM, V50, P425, DOI 10.1053/meta.2001.21693
   Smith Steven R, 2002, Curr Diab Rep, V2, P223, DOI 10.1007/s11892-002-0087-1
   Steppan CM, 2002, TRENDS ENDOCRIN MET, V13, P18, DOI 10.1016/S1043-2760(01)00522-7
   Steppan CM, 2001, NATURE, V409, P307, DOI 10.1038/35053000
   Talalay P, 1995, TOXICOL LETT, V82-3, P173, DOI 10.1016/0378-4274(95)03553-2
   Tirosh A, 2001, BIOCHEM J, V355, P757, DOI 10.1042/bj3550757
   Unger RH, 2000, INT J OBESITY, V24, pS28, DOI 10.1038/sj.ijo.0801498
   Wang H, 2002, J CLIN ENDOCR METAB, V87, P2520, DOI 10.1210/jc.87.6.2520
   Way JM, 2001, J BIOL CHEM, V276, P25651, DOI 10.1074/jbc.C100189200
   WEINTRAUB H, 1990, P NATL ACAD SCI USA, V87, P5623, DOI 10.1073/pnas.87.15.5623
NR 41
TC 148
Z9 160
U1 0
U2 7
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD JUL
PY 2003
VL 52
IS 7
BP 1611
EP 1618
DI 10.2337/diabetes.52.7.1611
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 695PF
UT WOS:000183838900004
PM 12829623
OA hybrid
DA 2025-06-11
ER

PT J
AU Parente, DJ
   Garriga, C
   Baskin, B
   Douglas, G
   Cho, MT
   Araujo, GC
   Shinawi, M
AF Parente, Daniel J.
   Garriga, Caryn
   Baskin, Berivan
   Douglas, Ganka
   Cho, Megan T.
   Araujo, Gabriel C.
   Shinawi, Marwan
TI Neuroligin 2 Nonsense Variant Associated with Anxiety, Autism,
   Intellectual Disability, Hyperphagia, and Obesity
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
DE NLGN2; anxiety; autism; obesity; synaptic function
ID GENE-EXPRESSION; MICE LACKING; SYNAPSE; SCHIZOPHRENIA; MUTATIONS;
   SYSTEMS
AB Neuroligins are post-synaptic, cellular adhesion molecules implicated in synaptic formation and function. NLGN2 is strongly linked to inhibitory, GABAergic signaling and is crucial for maintaining the excitation-inhibition balance in the brain. Disruption of the excitation-inhibition balance is associated with neuropsychiatric disease. In animal models, altered NLGN2 expression causes anxiety, developmental delay, motor discoordination, social impairment, aggression, and sensory processing defects. In humans, mutations in NLGN3 and NLGN4 are linked to autism and schizophrenia; NLGN2 missense variants are implicated in schizophrenia. Copy number variants encompassing NLGN2 on 17p13.1 are associated with autism, intellectual disability, metabolic syndrome, diabetes, and dysmorphic features, but an isolated NLGN2 nonsense variant has not yet been described in humans. Here, we describe a 15-year-old male with severe anxiety, obsessive-compulsive behaviors, developmental delay, autism, obesity, macrocephaly, and some dysmorphic features. Exome sequencing identified a heterozygous, de novo, c.441C>A p.(Tyr147Ter) variant in NLGN2 that is predicted to cause loss of normal protein function. This is the first report of an NLGN2 nonsense variant in humans, adding to the accumulating evidence that links synaptic proteins with a spectrum of neurodevelopmental phenotypes. (C) 2016 Wiley Periodicals, Inc.
C1 [Parente, Daniel J.] Univ Kansas, Med Ctr, Dept Family Med, Kansas City, KS 66103 USA.
   [Garriga, Caryn] St Louis Childrens Hosp, St Louis, MO 63178 USA.
   [Baskin, Berivan; Douglas, Ganka; Cho, Megan T.] GeneDx, Gaithersburg, MD USA.
   [Araujo, Gabriel C.] St Louis Childrens Hosp, Dept Psychol, St Louis, MO 63178 USA.
   [Shinawi, Marwan] Washington Univ, Sch Med, Dept Pediat, Div Genet & Genom Med, One Childrens Pl,Northwest Tower,9132, St Louis, MO 63110 USA.
C3 University of Kansas; University of Kansas Medical Center; Washington
   University (WUSTL); St. Louis Children's Hospital; Washington University
   (WUSTL); St. Louis Children's Hospital; Washington University (WUSTL)
RP Shinawi, M (corresponding author), Washington Univ, Sch Med, Dept Pediat, Div Genet & Genom Med, One Childrens Pl,Northwest Tower,9132, St Louis, MO 63110 USA.
EM shinawi_m@kids.wustl.edu
RI Parente, Daniel/AAM-3887-2021
OI shinawi, Marwan/0000-0003-1329-4100
CR Babaev O, 2016, NEUROPHARMACOLOGY, V100, P56, DOI 10.1016/j.neuropharm.2015.06.016
   Bang ML, 2013, NEUROCHEM RES, V38, P1174, DOI 10.1007/s11064-013-1029-9
   Blundell J, 2009, GENES BRAIN BEHAV, V8, P114, DOI 10.1111/j.1601-183X.2008.00455.x
   Deciphering Developmental Disorders Study, 2015, Nature, DOI [10.1038/nature14135, DOI 10.1038/NATURE14135]
   Hines RM, 2008, J NEUROSCI, V28, P6055, DOI 10.1523/JNEUROSCI.0032-08.2008
   Jamain S, 2003, NAT GENET, V34, P27, DOI 10.1038/ng1136
   Kang HS, 2004, REPROD FERT DEVELOP, V16, P763, DOI 10.1071/RD04040
   Kohl C, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0056871
   Lai JK, 2016, J COMP NEUROL, V524, P807, DOI 10.1002/cne.23868
   Liang J, 2015, MOL PSYCHIATR, V20, P850, DOI 10.1038/mp.2015.31
   Lionel AC, 2013, HUM MOL GENET, V22, P2055, DOI 10.1093/hmg/ddt056
   Miller JN, 2014, MUTAT RES-REV MUTAT, V762, P52, DOI 10.1016/j.mrrev.2014.05.001
   Pettem KL, 2013, J CELL BIOL, V200, P321, DOI 10.1083/jcb.201206028
   Rubenstein JLR, 2003, GENES BRAIN BEHAV, V2, P255, DOI 10.1034/j.1601-183X.2003.00037.x
   Sato I, 2005, J NEUROSCI, V25, P8657, DOI 10.1523/JNEUROSCI.2739-05.2005
   Suckow AT, 2012, J BIOL CHEM, V287, P19816, DOI 10.1074/jbc.M111.280537
   Sun CC, 2011, HUM MOL GENET, V20, P3042, DOI 10.1093/hmg/ddr208
   Tennessen JA, 2012, SCIENCE, V337, P64, DOI 10.1126/science.1219240
   van der Kooij MA, 2014, NEUROPSYCHOPHARMACOL, V39, P1148, DOI 10.1038/npp.2013.315
   Vong L, 2011, NEURON, V71, P142, DOI 10.1016/j.neuron.2011.05.028
   Wöhr M, 2013, BEHAV BRAIN RES, V251, P50, DOI 10.1016/j.bbr.2012.07.024
NR 21
TC 66
Z9 76
U1 1
U2 9
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4825
EI 1552-4833
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD JAN
PY 2017
VL 173
IS 1
BP 213
EP 216
DI 10.1002/ajmg.a.37977
PG 4
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Genetics & Heredity
GA EJ3TM
UT WOS:000393134900031
PM 27865048
DA 2025-06-11
ER

PT J
AU Park, HE
   Song, HY
   Han, K
   Cho, KH
   Kim, YH
AF Park, Hyo-Eun
   Song, Hye Young
   Han, Kyungdo
   Cho, Kyung-Hwan
   Kim, Yang-Hyun
TI Number of remaining teeth and health-related quality of life: the Korean
   National Health and Nutrition Examination Survey 2010-2012
SO HEALTH AND QUALITY OF LIFE OUTCOMES
LA English
DT Article
DE Remaining teeth; Quality of life; EQ-5D; Korean National Health and
   nutrition examination survey
ID ORAL-HEALTH; GENERAL HEALTH; COMPLETE DENTURES; IMPACT; MULTIATTRIBUTE;
   ASSOCIATION; MODEL; AGE
AB Objectives/aimsWith the Euro-Qol-5 dimension (EQ-5D) system, we investigated the relationship between the number of remaining teeth and QoL using data from the Korean National Health and Nutrition Examination Survey (KNHANES), 2010-2012. A total of 17,417 participants, more than 19years old, were finally included in this study (men=7394 and women=10,023). Through this study, we have discovered that the remaining teeth affect overall health and that the fewer number of them may indicate a lower quality of life, as well.The quality of life according to the number of remaining teeth was assessed among Koreans using the Euro-Qol-5 dimension (EQ-5D) system.MethodThe Euro-Qol-5 dimension (EQ-5D) system was used to measure the health-related QoL. Its five dimensions included mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. The respondents were asked to choose one of the followings: G 1, no problems; G 2, some problems; and G 3, problematic, to best describe their health status for the five dimensions. Then, we assigned low QoL to G2+G3 and high QoL to G1.We used age, gender, economic income, educational level, residence, and marital status for the demographic variables and, drinking, smoking, exercise, BMI, and metabolic syndrome for health behaviors. Multiple logistic regression analysis was performed to examine the odds ratios (ORs) and confidence intervals (CIs) for the high QoL (G1) on the five categories of EQ-5D according to the number of remaining teeth. On the basis of the 0-15 remaining teeth group, we drew a comparison of the QoL between the 16-20 and 21-28 remaining teeth groups.ResultsSubjects with 21-28 remaining teeth had higher QoL scores and had higher ORs of high QoL, especially for mobility (OR=1.256, 95% CI=1.056-1.495), self-care (OR=1.441, 95% CI=1.096-1.894), and usual activities (OR=1.241, 95% CI=1.022-1.508, respectively), than those with 0-15 remaining teeth after adjusting for age, sex, body mass index, smoking, drinking, exercise, income, education, and metabolic syndrome.ORs from the high QoL had the tendency to increase as the number of remaining teeth increased (all p for trend <0.05). However, there was no relationship between the number of remaining teeth and QoL in the pain/discomfort and anxiety/depression dimensions.ConclusionThe number of remaining teeth was associated with QoL, and subjects who had more teeth obtained higher QoL scores. The subjects in the high QoL group were especially associated with the components of EQ-5D such as mobility, self-care, and daily living.
C1 [Park, Hyo-Eun] Korea Univ, Coll Nursing, Grad Sch Nursing, Seoul, South Korea.
   [Park, Hyo-Eun] Suwon Womens Univ, Dept Nursing, 72 Onjeong Ro, Suwon, Gyeonggi, South Korea.
   [Song, Hye Young] Ewha Womans Univ Korea, Grad Sch Nursing, Seoul, South Korea.
   [Han, Kyungdo] Catholic Univ, Coll Med, Dept Med Stat, Seoul, South Korea.
   [Cho, Kyung-Hwan; Kim, Yang-Hyun] Korea Univ, Anam Hosp, Coll Med, Dept Family Med, 73 Inchon Ro, Seoul 02841, South Korea.
C3 Korea University; Ewha Womans University; Catholic University of Korea;
   Korea University; Korea University Medicine (KU Medicine)
RP Kim, YH (corresponding author), Korea Univ, Anam Hosp, Coll Med, Dept Family Med, 73 Inchon Ro, Seoul 02841, South Korea.
EM lisa0713@swc.ac.kr; mrchir@naver.com
RI Han, Kyungdo/JKH-7628-2023; Kim, Jinkwon/AAR-6729-2021
OI Kim, Yang-Hyun/0000-0003-3548-8758
CR Accessed 25Apr2017, 2002, BASELINE STUDY DENTU
   Agarwal DP, 2002, ALCOHOL ALCOHOLISM, V37, P409, DOI 10.1093/alcalc/37.5.409
   Akifusa S, 2005, Gerodontology, V22, P91, DOI 10.1111/j.1741-2358.2005.00059.x
   Gil-Montoya JA, 2015, CLIN INTERV AGING, V10, DOI 10.2147/CIA.S54630
   Back JU, 2012, KPHR, V38, P81
   Brazier J, 2002, J HEALTH ECON, V21, P271, DOI 10.1016/S0167-6296(01)00130-8
   Brennan DS, 2012, J NUTR HEALTH AGING, V16, P437, DOI 10.1007/s12603-012-0006-3
   Brennan DS, 2015, COMMUNITY DENT ORAL, V43, P282, DOI 10.1111/cdoe.12152
   Brennan DS, 2011, EUR J ORAL SCI, V119, P469, DOI 10.1111/j.1600-0722.2011.00873.x
   Buhlin K, 2002, J CLIN PERIODONTOL, V29, P254, DOI 10.1034/j.1600-051x.2002.290312.x
   Burström K, 2001, QUAL LIFE RES, V10, P621, DOI 10.1023/A:1013171831202
   Cassolato Sandra F, 2003, Gerodontology, V20, P64, DOI 10.1111/j.1741-2358.2003.00064.x
   Catovic A, 2003, J DENT, V31, P3, DOI 10.1016/S0300-5712(02)00129-X
   Centers for Disease Control & Prevention Disease Prevention Center Chronic Disease Control Researcher Seoul National University School of Dentistry Preventive and Public Health Dentistry, ASS PER SYST DIS
   Chen YF, 2012, J DENT SCI, V7, P289, DOI 10.1016/j.jds.2012.06.004
   Chun YH, 2013, LIPIDS HEALTH DIS, V12, DOI 10.1186/1476-511X-12-84
   Cushing A M, 1986, Community Dent Health, V3, P3
   Feeny D, 2002, MED CARE, V40, P113, DOI 10.1097/00005650-200202000-00006
   Fontanive V, 2013, COMMUNITY DENT ORAL, V41, P154, DOI 10.1111/j.1600-0528.2012.00742.x
   Glasgow RE, 1997, DIABETES CARE, V20, P562, DOI 10.2337/diacare.20.4.562
   Han Mi Ah, 2008, J Prev Med Public Health, V41, P173
   Heydecke G, 2004, COMMUNITY DENT ORAL, V32, P297, DOI 10.1111/j.1600-0528.2004.00169.x
   Heydecke G, 2003, COMMUNITY DENT ORAL, V31, P161, DOI 10.1034/j.1600-0528.2003.00029.x
   Hoi LV, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-549
   Hugo FN, 2009, COMMUNITY DENT ORAL, V37, P231, DOI 10.1111/j.1600-0528.2009.00459.x
   Ikebe K, 2007, ORAL SURG ORAL MED O, V103, P216, DOI 10.1016/j.tripleo.2005.12.001
   Kandelman D, 2008, SPEC CARE DENT, V28, P224, DOI 10.1111/j.1754-4505.2008.00045.x
   KAPLAN RM, 1988, HEALTH SERV RES, V23, P203
   Kim SW, 2016, INT J CHRONIC OBSTR, V11, P13, DOI 10.2147/COPD.S94419
   Kim SH, 2016, QUAL LIFE RES, V25, P1845, DOI 10.1007/s11136-015-1205-2
   KNAPP A, 1989, DENT CLIN N AM, V33, P109
   Korea National Institute of Special Education, 2009, DICT SPEC ED
   KUYKEN W, 1995, SOC SCI MED, V41, P1403, DOI 10.1016/0277-9536(95)00112-k
   Kwon KM, 2017, HEALTH QUAL LIFE OUT, V15, DOI 10.1186/s12955-017-0816-4
   Laguna L, 2015, PHYSIOL BEHAV, V147, P274, DOI 10.1016/j.physbeh.2015.04.052
   Lang HC, 2010, SUPPORT CARE CANCER, V18, P1279, DOI 10.1007/s00520-009-0745-9
   Lawrence HP, 2008, COMMUNITY DENT ORAL, V36, P305, DOI 10.1111/j.1600-0528.2007.00395.x
   Lee Hyun-Ok, 2008, [Journal of Dental Hygiene Science, 치위생과학회지], V8, P57
   Locker D, 1994, Gerodontology, V11, P108, DOI 10.1111/j.1741-2358.1994.tb00116.x
   Loesche W J, 1994, Compendium, V15, P978
   Makhija SK, 2011, J AM GERIATR SOC, V59, P512, DOI 10.1111/j.1532-5415.2010.03306.x
   Masood M, 2017, J DENT, V56, P78, DOI 10.1016/j.jdent.2016.11.002
   Miura H, 2010, ARCH GERONTOL GERIAT, V51, pE62, DOI 10.1016/j.archger.2009.12.003
   Naito M, 2010, ARCH GERONTOL GERIAT, V50, P65, DOI 10.1016/j.archger.2009.01.013
   Oh JY, 2007, KOREAN J FAM MED, V28, P532
   김설희, 2004, [Journal of Korean Academy of Oral Health, 대한구강보건학회지], V28, P559
   Rubin RR, 1999, DIABETES-METAB RES, V15, P205, DOI 10.1002/(SICI)1520-7560(199905/06)15:3<205::AID-DMRR29>3.0.CO;2-O
   이영훈, 2009, [KOREAN JOURNAL OF HEALTH EDUCATION AND PROMOTION, 보건교육건강증진학회지], V26, P1
   Sandberg GE, 2001, ACTA ODONTOL SCAND, V59, P28, DOI 10.1080/000163501300035742
   Somsak K, 2016, GERODONTOLOGY, V33, P52, DOI 10.1111/ger.12112
   Sonoyama W, 2002, CLIN ORAL IMPLAN RES, V13, P359, DOI 10.1034/j.1600-0501.2002.130403.x
   Spilker B, 1996, QUALITY LIFE PHARMAC, V25, P31
   Steele JG, 2004, COMMUNITY DENT ORAL, V32, P107, DOI 10.1111/j.0301-5661.2004.00131.x
   Torrance GW, 1996, MED CARE, V34, P702, DOI 10.1097/00005650-199607000-00004
   Wallander JL, 1998, J CHILD PSYCHOL PSYC, V39, P29, DOI 10.1017/S0021963097001741
   WILLIAMS A, 1990, HEALTH POLICY, V16, P199
   WILSON IB, 1995, JAMA-J AM MED ASSOC, V273, P59, DOI 10.1001/jama.273.1.59
   한정희, 2012, [The Journal of Fundamentals of Nursing, 기본간호학회지], V19, P179
   Zygmuntowicz M, 2012, POL ARCH MED WEWN, V122, P333, DOI 10.20452/pamw.1345
NR 59
TC 28
Z9 29
U1 2
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1477-7525
J9 HEALTH QUAL LIFE OUT
JI Health Qual. Life Outcomes
PD JAN 9
PY 2019
VL 17
AR 5
DI 10.1186/s12955-019-1078-0
PG 10
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA HH0EW
UT WOS:000455387400001
PM 30626402
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Giltay, EJ
   Tishova, YA
   Mskhalaya, GJ
   Gooren, LJG
   Saad, F
   Kalinchenko, SY
AF Giltay, Erik J.
   Tishova, Yuliya A.
   Mskhalaya, George J.
   Gooren, Louis J. G.
   Saad, Farid
   Kalinchenko, Svetlana Y.
TI Effects of Testosterone Supplementation on Depressive Symptoms and
   Sexual Dysfunction in Hypogonadal Men with the Metabolic Syndrome
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE Randomized Trial; Testosterone Administration; Metabolic Syndrome;
   Depression; Placebo-controlled; Sexual Dysfunction
ID QUALITY-OF-LIFE; LATE-ONSET HYPOGONADISM; OLDER MEN; DOUBLE-BLIND;
   REPLACEMENT THERAPY; TRANSDERMAL DIHYDROTESTOSTERONE; BIOAVAILABLE
   TESTOSTERONE; ERECTILE DYSFUNCTION; INTERNATIONAL INDEX; ANDROGEN
   DEFICIENCY
AB Introduction.
   Low testosterone levels in men are associated with the metabolic syndrome (MetS) as well as with depressive symptoms, low vitality, and sexual dysfunction.
   Aim.
   To assess the effects of testosterone administration on these subjective symptoms, which have not extensively been studied in hypogonadal men with the MetS.
   Main Outcome Measures.
   The Beck Depression Inventory (BDI-IA), Aging Males' Symptoms (AMS) scale, and International Index of Erectile Function 5-item (IIEF-5) scale at baseline, 18 and 30 weeks were analysed using multilevel analysis.
   Methods.
   In a randomized, placebo-controlled, double-blind, phase III trial (ClinicalTrials.gov identifier: NCT00696748), 184 men suffering from both the MetS and hypogonadism were included. They were treated for 30 weeks with either parenteral testosterone undecanoate (TU; 1,000 mg IM TU, at baseline, and after 6 and 18 weeks; Nebido (R)) or placebo injections, 105 (92.9%) men receiving TU and 65 (91.5%) receiving placebo completed the 30-week trial.
   Results.
   The 184 men were aged mean 52.1 years old (standard deviation [SD] 9.6; range 35-69), with a mean body mass index of 35.5 kg/m2 (SD 6.7; range 25.1-54.8), and a mean total testosterone level of 8.0 nmol/L (SD 4.0). There were significant improvements in BDI-IA (mean difference vs. placebo after 30 weeks: -2.5 points; 95% confidence interval [CI]: -0.9; -4.1; P = 0.003), AMS (-7.4 points; 95% CI: -4.3; -10.5; P < 0.001), and IIEF-5 (+3.1 points; 95% CI: +1.8; +4.4; P < 0.001). The effects on the BDI-IA, AMS, and IIEF-5 were strongest in men with baseline total testosterone levels < 7.7 mmol/L (i.e., median value).
   Conclusions.
   TU administration may improve depressive symptoms, aging male symptoms and sexual dysfunction in hypogonadal men with the MetS. The beneficial effects of testosterone were most evident in men with the lowest baseline total testosterone levels. Giltay EJ, Tishova YA, Mskhalaya GJ, Gooren LJG, Saad F, and Kalinchenko SY. Effects of testosterone supplementation on depressive symptoms and sexual dysfunction in hypogonadal men with the metabolic syndrome. J Sex Med 2010;7:2572-2582.
C1 [Giltay, Erik J.] Leiden Univ, Med Ctr, Dept Psychiat, NL-2300 RC Leiden, Netherlands.
   [Tishova, Yuliya A.; Mskhalaya, George J.; Kalinchenko, Svetlana Y.] Peoples Friendship Univ Russia, Chair Endocrinol, Fac Med Staff Refresher Training, Moscow, Russia.
   [Gooren, Louis J. G.] Vrije Univ Amsterdam, Med Ctr, Dept Endocrinol, Amsterdam, Netherlands.
   [Saad, Farid] Bayer Schering Pharma, Sci Affairs Mens Healthcare, Berlin, Germany.
   [Saad, Farid] Gulf Med Univ, Sch Med, Ajman, U Arab Emirates.
C3 Leiden University - Excl LUMC; Leiden University; Leiden University
   Medical Center (LUMC); Peoples Friendship University of Russia; Vrije
   Universiteit Amsterdam; Bayer AG; Bayer Healthcare Pharmaceuticals
RP Giltay, EJ (corresponding author), Leiden Univ, Med Ctr, Dept Psychiat, POB 9600, NL-2300 RC Leiden, Netherlands.
EM giltay@dds.nl
RI Saad, Farid/AAW-2694-2020; Giltay, Erik/AAL-9948-2021
OI Giltay, Erik J./0000-0001-8874-2292
CR Akbaraly TN, 2009, DIABETES CARE, V32, P499, DOI 10.2337/dc08-1358
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Almeida OP, 2004, PSYCHONEUROENDOCRINO, V29, P1071, DOI 10.1016/j.psyneuen.2003.11.002
   Almeida OP, 2008, ARCH GEN PSYCHIAT, V65, P283, DOI 10.1001/archgenpsychiatry.2007.33
   Amiaz R, 2008, CURR OPIN ENDOCRINOL, V15, P278, DOI 10.1097/MED.0b013e3282fc27eb
   Barrett-Connor E, 1999, J CLIN ENDOCR METAB, V84, P573, DOI 10.1210/jc.84.2.573
   Beck AT, 1996, J PERS ASSESS, V67, P588, DOI 10.1207/s15327752jpa6703_13
   BECK AT, 1988, CLIN PSYCHOL REV, V8, P77, DOI 10.1016/0272-7358(88)90050-5
   Bhasin S, 2006, J CLIN ENDOCR METAB, V91, P1995, DOI 10.1210/jc.2005-2847
   Boloña ER, 2007, MAYO CLIN PROC, V82, P20, DOI 10.4065/82.1.20
   Boyanov M A, 2003, Aging Male, V6, P1
   Calof OM, 2005, J GERONTOL A-BIOL, V60, P1451, DOI 10.1093/gerona/60.11.1451
   Chiang HS, 2007, INT J IMPOT RES, V19, P411, DOI 10.1038/sj.ijir.3901562
   Corona G, 2008, J SEX MED, V5, P2454, DOI 10.1111/j.1743-6109.2008.00856.x
   Daig Isolde, 2003, Health Qual Life Outcomes, V1, P77, DOI 10.1186/1477-7525-1-77
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   Emmelot-Vonk MH, 2008, JAMA-J AM MED ASSOC, V299, P39, DOI 10.1001/jama.2007.51
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Haren MT, 2005, MATURITAS, V50, P124, DOI 10.1016/j.maturitas.2004.05.002
   Heinemann Lothar A J, 2003, Health Qual Life Outcomes, V1, P15, DOI 10.1186/1477-7525-1-15
   Hintikka J, 2009, J SEX MED, V6, P2049, DOI 10.1111/j.1743-6109.2009.01299.x
   Hossain P, 2007, NEW ENGL J MED, V356, P213, DOI 10.1056/NEJMp068177
   Isidori AM, 2005, CLIN ENDOCRINOL, V63, P381, DOI 10.1111/j.1365-2265.2005.02350.x
   Kalyani Rita R, 2007, Curr Opin Endocrinol Diabetes Obes, V14, P226, DOI 10.1097/MED.0b013e32814db856
   Kapoor D, 2006, EUR J ENDOCRINOL, V154, P899, DOI 10.1530/eje.1.02166
   Kaufman JM, 2005, ENDOCR REV, V26, P833, DOI 10.1210/er.2004-0013
   Kenny AM, 2004, J GERONTOL A-BIOL, V59, P75
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178, DOI 10.4088/JCP.v69n0202
   Kunelius P, 2002, J CLIN ENDOCR METAB, V87, P1467, DOI 10.1210/jc.87.4.1467
   Legros JJ, 2009, EUR J ENDOCRINOL, V160, P821, DOI 10.1530/EJE-08-0634
   Liu PY, 2003, J CLIN ENDOCR METAB, V88, P3605, DOI 10.1210/jc.2003-030236
   Ly LP, 2001, J CLIN ENDOCR METAB, V86, P4078, DOI 10.1210/jc.86.9.4078
   McCaffery JM, 2003, PSYCHOSOM MED, V65, P490, DOI 10.1097/01.PSY.0000041545.52924.82
   McIntyre RS, 2006, PSYCHONEUROENDOCRINO, V31, P1029, DOI 10.1016/j.psyneuen.2006.06.005
   Merza Z, 2006, INT J ANDROL, V29, P381, DOI 10.1111/j.1365-2605.2005.00612.x
   Moore C, 2004, EUR UROL, V46, P80, DOI 10.1016/j.eururo.2004.01.009
   Morley JE, 2000, METABOLISM, V49, P1239, DOI 10.1053/meta.2000.8625
   Perry PJ, 2002, J CLIN PSYCHIAT, V63, P1096, DOI 10.4088/JCP.v63n1202
   Pope HG, 2003, AM J PSYCHIAT, V160, P105, DOI 10.1176/appi.ajp.160.1.105
   Reddy P, 2000, J CLIN PHARM THER, V25, P421, DOI 10.1046/j.1365-2710.2000.00309.x
   Rhoden EL, 2004, NEW ENGL J MED, V350, P482, DOI 10.1056/NEJMra022251
   Rizvi SJ, 2010, J SEX MED, V7, P816, DOI 10.1111/j.1743-6109.2009.01504.x
   Roberts RE, 2003, INT J OBESITY, V27, P514, DOI 10.1038/sj.ijo.0802204
   Rosen RC, 1997, UROLOGY, V49, P822, DOI 10.1016/S0090-4295(97)00238-0
   Rosen RC, 1999, INT J IMPOT RES, V11, P319, DOI 10.1038/sj.ijir.3900472
   Schubert M, 2004, J CLIN ENDOCR METAB, V89, P5429, DOI 10.1210/jc.2004-0897
   Seidman SN, 2006, J SEX MARITAL THER, V32, P267, DOI 10.1080/00926230600575355
   Seidman SN, 2005, J CLIN PSYCHOPHARM, V25, P584, DOI 10.1097/01.jcp.0000185424.23515.e5
   Seidman SN, 2003, J CLIN PSYCHIAT, V64, P31
   Seidman SN, 2001, J CLIN PSYCHIAT, V62, P406, DOI 10.4088/JCP.v62n0602
   Shahinian VB, 2006, ARCH INTERN MED, V166, P465
   Shores MM, 2005, J CLIN PSYCHIAT, V66, P7, DOI 10.4088/JCP.v66n0102
   Shores MM, 2009, J CLIN PSYCHIAT, V70, P1009, DOI 10.4088/JCP.08m04478
   Sih R, 1997, J CLIN ENDOCR METAB, V82, P1661, DOI 10.1210/jc.82.6.1661
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Steidle C, 2003, J CLIN ENDOCR METAB, V88, P2673, DOI 10.1210/jc.2002-021058
   Vermeulen A, 1999, J CLIN ENDOCR METAB, V84, P3666, DOI 10.1210/jc.84.10.3666
   Wang C, 2009, AGING MALE, V12, P5, DOI 10.1080/13685530802389628
   Zarrour FA, 2009, J PSYCHIATR PRACT, V15, P289, DOI 10.1097/01.pra.0000358315.88931.fc
   Zitzmann M, 2007, J CLIN ENDOCR METAB, V92, P3844, DOI 10.1210/jc.2007-0620
   Zitzmann M, 2006, J CLIN ENDOCR METAB, V91, P4335, DOI 10.1210/jc.2006-0401
NR 61
TC 99
Z9 106
U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD JUL
PY 2010
VL 7
IS 7
BP 2572
EP 2582
DI 10.1111/j.1743-6109.2010.01859.x
PG 11
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Urology & Nephrology
GA 621XP
UT WOS:000279620100028
PM 20524974
DA 2025-06-11
ER

PT J
AU Morvaridzadeh, M
   Cohen, AA
   Heshmati, J
   Alami, M
   Berrougui, H
   Zoubdane, N
   Pizarro, AB
   Khalil, A
AF Morvaridzadeh, Mojgan
   Cohen, Alan A.
   Heshmati, Javad
   Alami, Mehdi
   Berrougui, Hicham
   Zoubdane, Nada
   Pizarro, Ana Beatriz
   Khalil, Abdelouahed
TI Effect of Extra Virgin Olive Oil on Anthropometric Indices, Inflammatory
   and Cardiometabolic Markers: a Systematic Review and Meta-Analysis of
   Randomized Clinical Trials
SO JOURNAL OF NUTRITION
LA English
DT Article
DE extra virgin olive oil; cardiometabolic biomarkers; glycemic control;
   lipid profile; inflammation
ID CARDIOVASCULAR RISK-FACTORS; CHRONIC KIDNEY-DISEASE; LIPID PROFILE;
   CORN-OIL; SECONDARY PREVENTION; MEDITERRANEAN DIET; OXIDATIVE STRESS;
   BLOOD-PRESSURE; PALM OIL; CHOLESTEROL
AB Background: A large body of literature associated extra virgin olive oil (EVOO) consumption with low risk of cardiovascular disease and mortality. However, findings from clinical trials related to EVOO consumption on blood pressure, lipid profile, and anthropometric and inflammation parameters are not univocal. Objectives: The aim of this systematic review and meta -analysis was to evaluate the effect of EVOO consumption on cardiometabolic risk factors and inflammatory mediators. Methods: We searched PubMed/MEDLINE, Scopus, and Cochrane up through 31 March, 2023, without any particular language limitations, in order to identify randomized controlled trials (RCTs) that examined the effects of EVOO consumption on cardiometabolic risk factors, inflammatory mediators, and anthropometric indices. Outcomes were summarized as standardized mean difference (SMD) with 95% confidence intervals (CIs) estimated from Hedge's g and random -effects modeling. Heterogeneity was assessed by Cochran Q -statistic and quantified (I2). Results: Thirty-three trials involving 2020 participants were included. EVOO consumption was associated with a significant decrease in insulin (n = 10; SMD: -0.28; 95% CI: -0.51, -0.05; I2 = 48.57%) and homeostasis model assessment of insulin resistance levels (HOMA-IR) (n = 9; SMD: -0.19; 95% CI: -0.35, -0.03; I2 = 00.00%). This meta -analysis indicated no significant effect of consuming EVOO on fasting blood glucose, triglycerides, total cholesterol, low density lipoproteins, very low density lipoproteins, high density lipoproteins, Apolipoprotein (Apo) A -I and B, lipoprotein a, blood pressure, body mass index, waist circumference, waist to hip ratio, C -reactive protein, interleukin-6, interleukin-10, and tumor necrosis factor alpha levels (P > 0.05). Conclusions: The present evidence supports a beneficial effect of EVOO consumption on serum insulin levels and HOMA-IR. However, larger well -designed RCTs are still required to evaluate the effect of EVOO on cardiometabolic risk biomarkers. This study was registered in PROSPERO as CRD42023409125.
C1 [Morvaridzadeh, Mojgan; Heshmati, Javad; Alami, Mehdi; Berrougui, Hicham; Zoubdane, Nada; Khalil, Abdelouahed] Univ Sherbrooke, Fac Med & Hlth Sci, Dept Med, Geriatr Unit, Sherbrooke, PQ, Canada.
   [Cohen, Alan A.] Columbia Univ, Butler Columbia Aging Ctr, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, New York, NY USA.
   [Alami, Mehdi; Berrougui, Hicham] Univ Sultan Moulay Slimane, Polydisciplinary Fac, Dept Biol, Beni Mellal, Morocco.
   [Pizarro, Ana Beatriz] Fdn Valle Lili, Clin Res Ctr, Cali, Colombia.
C3 University of Sherbrooke; Columbia University; Sultan Moulay Slimane
   University of Beni Mellal; Fundacion Valle del Lili
RP Khalil, A (corresponding author), Univ Sherbrooke, Fac Med & Hlth Sci, Dept Med, Geriatr Unit, Sherbrooke, PQ, Canada.
EM abdelouahed.khalil@usherbrooke.ca
RI Morvaridzadeh, Mojgan/GLU-6418-2022; heshmati, javad/H-6812-2019;
   Pizarro, Ana/AAC-8021-2022
OI Pizarro, Ana Beatriz/0000-0003-4089-454X
FU Canadian Institutes of Health Research [PJT-162366]
FX This research was funded by the Canadian Institutes of Health Research,
   grant numbers (PJT-162366) .
CR Aguilera CM, 2004, CLIN NUTR, V23, P673, DOI 10.1016/j.clnu.2003.11.005
   Andrade C, 2020, J CLIN PSYCHIAT, V81, DOI 10.4088/JCP.20f13681
   Appel LJ, 2005, JAMA-J AM MED ASSOC, V294, P2455, DOI 10.1001/jama.294.19.2455
   Atefi M, 2018, J DIABETES METAB DIS, V17, P85, DOI 10.1007/s40200-018-0343-9
   Atefi M, 2018, PROG NUTR, V20, P102, DOI 10.23751/pn.v20i1-S.5854
   Bahrololumi S.S., 2014, J. Endocrinol. Metab., V15, P527
   Bennett JM, 2018, FRONT MED-LAUSANNE, V5, DOI 10.3389/fmed.2018.00316
   Berrougui H, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/208062
   Bozzetto L, 2016, DIABETES CARE, V39, P518, DOI 10.2337/dc15-2189
   Burke LM, 2021, J PHYSIOL-LONDON, V599, P771, DOI 10.1113/JP280221
   Campos VP, 2020, J HUM NUTR DIET, V33, P439, DOI 10.1111/jhn.12727
   Cândido FG, 2018, EUR J NUTR, V57, P2445, DOI 10.1007/s00394-017-1517-9
   Chen BK, 2011, GLOBALIZATION HEALTH, V7, DOI 10.1186/1744-8603-7-45
   Cheng C, 2019, INT J FOOD SCI NUTR, V70, P355, DOI 10.1080/09637486.2018.1504009
   Cohen J., 1988, STAT POWER ANAL BEHA, DOI [10.4324/9780203771587, DOI 10.4324/9780203771587]
   Delgado-Lista J, 2022, LANCET, V399, P1876, DOI 10.1016/S0140-6736(22)00122-2
   Deng PH, 2023, INT J EQUITY HEALTH, V22, DOI 10.1186/s12939-023-01988-2
   Ding MZ, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-03959-5
   Donat-Vargas C, 2022, CLIN NUTR, V41, P122, DOI 10.1016/j.clnu.2021.11.002
   dos Santos JL, 2022, EUR J CLIN NUTR, V76, P827, DOI 10.1038/s41430-021-01045-7
   Estruch R, 2018, NEW ENGL J MED, V378, DOI [10.1056/NEJMoa1800389, 10.1056/NEJMoa1200303, 10.1056/nejmoa1800389]
   Foshati S, 2021, INT J CLIN PRACT, V75, DOI 10.1111/ijcp.14254
   Fritzen AM, 2020, NAT REV ENDOCRINOL, V16, P683, DOI 10.1038/s41574-020-0405-1
   Gaforio JJ, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092039
   George ES, 2019, CRIT REV FOOD SCI, V59, P2772, DOI 10.1080/10408398.2018.1470491
   Gesteiro E, 2018, NUTR HOSP, V35, P1229, DOI 10.20960/nh.1970
   Gharby Said, 2022, ScientificWorldJournal, V2022, P6627013, DOI 10.1155/2022/6627013
   Ghobadi S, 2019, CRIT REV FOOD SCI, V59, P2110, DOI 10.1080/10408398.2018.1438349
   Gimeno E, 2007, BRIT J NUTR, V98, P1243, DOI 10.1017/S0007114507778698
   Granholm A, 2019, BRIT J ANAESTH, V123, P554, DOI 10.1016/j.bja.2019.08.015
   Hohmann CD, 2015, PHYTOMEDICINE, V22, P631, DOI 10.1016/j.phymed.2015.03.019
   Hsieh MJ, 2022, MOLECULES, V27, DOI 10.3390/molecules27103235
   Isaakidis A, 2023, NUTRIENTS, V15, DOI 10.3390/nu15163625
   Ul Islam S, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10050784
   Jimenez-Lopez C, 2020, FOODS, V9, DOI 10.3390/foods9081014
   Kabiri A, 2017, INT J FOOD SCI NUTR, V68, P560, DOI 10.1080/09637486.2016.1261808
   Khalafallah A, 2010, MEDITERR J HEMATOL I, V2, DOI [10.4084/MJHID.2010.005, 10.1136/bmj.l4898]
   Khaw KT, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2017-020167
   Laffond A, 2023, NUTRIENTS, V15, DOI 10.3390/nu15153356
   LICHTENSTEIN AH, 1993, ARTERIOSCLER THROMB, V13, P1533, DOI 10.1161/01.ATV.13.10.1533
   Loganathan R, 2022, NUTR RES, V105, P113, DOI 10.1016/j.nutres.2022.06.011
   Longhi R, 2021, NUTRIENTS, V13, DOI 10.3390/nu13114139
   Lucci P, 2020, FOODS, V9, DOI 10.3390/foods9030292
   Lukic M, 2021, HORTICULTURAE, V7, DOI 10.3390/horticulturae7110493
   Maki KC, 2017, EUR J CLIN NUTR, V71, P33, DOI 10.1038/ejcn.2016.169
   Maki KC, 2015, J CLIN LIPIDOL, V9, P49, DOI 10.1016/j.jacl.2014.10.006
   Martínez-González MA, 2022, CLIN NUTR, V41, P2659, DOI 10.1016/j.clnu.2022.10.001
   Massaro M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061548
   Mehmood A, 2020, FOOD SCI NUTR, V8, P4639, DOI 10.1002/fsn3.1668
   Moher D, 2009, J CLIN EPIDEMIOL, V62, P1006, DOI 10.1016/j.jclinepi.2009.06.005
   Mousavi S, 2021, FOODS, V10, DOI 10.3390/foods10081945
   NG TKW, 1992, J AM COLL NUTR, V11, P383
   Oliveras-López MJ, 2013, ARCH GERONTOL GERIAT, V57, P234, DOI 10.1016/j.archger.2013.04.002
   Pastor R, 2021, FREE RADICAL BIO MED, V172, P372, DOI 10.1016/j.freeradbiomed.2021.06.017
   Pérez Bañasco V, 2007, NEFROLOGIA, V27, P472
   Prater MC, 2022, J NUTR, V152, P2060, DOI 10.1093/jn/nxac099
   Rozati M, 2015, NUTR METAB, V12, DOI 10.1186/s12986-015-0022-5
   Rudrapal M, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.806470
   Rus A, 2020, NUTRIENTS, V12, DOI 10.3390/nu12040918
   Schwingshackl L, 2017, NUTR DIABETES, V7, DOI 10.1038/nutd.2017.12
   Schwingshackl L, 2015, NUTRIENTS, V7, P7651, DOI 10.3390/nu7095356
   Scoditti E, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0128218
   Shidfar F, 2018, CAN J GASTROENTEROL, V2018, DOI 10.1155/2018/1053710
   Silva S, 2015, AM J CLIN NUTR, V101, P44, DOI 10.3945/ajcn.114.094219
   SIRTORI CR, 1992, AM J CLIN NUTR, V56, P113, DOI 10.1093/ajcn/56.1.113
   Sterne JAC, 2001, J CLIN EPIDEMIOL, V54, P1046, DOI 10.1016/S0895-4356(01)00377-8
   Stonehouse W, 2020, EUR J CLIN NUTR, V74, P268, DOI 10.1038/s41430-019-0452-7
   Sun GJ, 2018, ASIA PAC J CLIN NUTR, V27, P572, DOI 10.6133/apjcn.032017.12
   Sun Y, 2015, J NUTR, V145, P1549, DOI 10.3945/jn.115.210575
   Tuccinardi D, 2022, DIABETES-METAB RES, V38, DOI 10.1002/dmrr.3492
   Venturini D, 2015, NUTRITION, V31, P834, DOI 10.1016/j.nut.2014.12.016
   Visioli F, 2018, NUTR METAB CARDIOVAS, V28, P649, DOI 10.1016/j.numecd.2018.04.004
   Visioli F, 2005, EUR J NUTR, V44, P121, DOI 10.1007/s00394-004-0504-0
   Visioli F, 2020, BRIT J PHARMACOL, V177, P1316, DOI 10.1111/bph.14782
   Weschenfelder C, 2022, BRIT J NUTR, V127, P862, DOI 10.1017/S0007114521001513
   Wijayanthie N., 2019, Int. J. Appl. Pharm, V11, P56, DOI [10.22159/ijap.2019.v11s6.33540, DOI 10.22159/IJAP.2019.V11S6.33540]
   Wu MY, 2022, FOOD FUNCT, V13, P4375, DOI [10.1039/d1fo03759e, 10.1039/D1FO03759E]
   Zamora-Zamora F, 2018, GRASAS ACEITES, V69, DOI 10.3989/gya.0105181
   Zhang JL, 2023, NUTR METAB CARDIOVAS, V33, P2344, DOI 10.1016/j.numecd.2023.07.039
NR 79
TC 14
Z9 15
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD JAN
PY 2024
VL 154
IS 1
BP 95
EP 120
DI 10.1016/j.tjnut.2023.10.028
EA JAN 2024
PG 26
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ID3G9
UT WOS:001164343100001
PM 37977313
OA Bronze
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Hoemann, K
   Khan, Z
   Kamona, N
   Dy, J
   Barrett, LF
   Quigley, KS
AF Hoemann, Katie
   Khan, Zulqarnain
   Kamona, Nada
   Dy, Jennifer
   Barrett, Lisa Feldman
   Quigley, Karen S.
TI Investigating the relationship between emotional granularity and
   cardiorespiratory physiological activity in daily life
SO PSYCHOPHYSIOLOGY
LA English
DT Article
DE ambulatory assessment; ECG; emotion differentiation; experience
   sampling; heart rate variability; respiratory sinus arrhythmia
ID HEART-RATE-VARIABILITY; RESPIRATORY SINUS ARRHYTHMIA; AUTONOMIC
   NERVOUS-SYSTEM; GROWTH MIXTURE-MODELS; BORDERLINE PERSONALITY; METABOLIC
   SYNDROME; ANXIETY DISORDER; INTEGRATED MODEL; CARDIAC CONTROL; NEGATIVE
   AFFECT
AB Emotional granularity describes the ability to create emotional experiences that are precise and context-specific. Despite growing evidence of a link between emotional granularity and mental health, the physiological correlates of granularity have been under-investigated. This study explored the relationship between granularity and cardiorespiratory physiological activity in everyday life, with particular reference to the role of respiratory sinus arrhythmia (RSA), an estimate of vagal influence on the heart often associated with positive mental and physical health outcomes. Participants completed a physiologically triggered experience-sampling protocol including ambulatory recording of electrocardiogram, impedance cardiogram, movement, and posture. At each prompt, participants generated emotion labels to describe their current experience. In an end-of-day survey, participants elaborated on each prompt by rating the intensity of their experience on a standard set of emotion adjectives. Consistent with our hypotheses, individuals with higher granularity exhibited a larger number of distinct patterns of physiological activity during seated rest, and more situationally precise patterns of activity during emotional events: granularity was positively correlated with the number of clusters of cardiorespiratory physiological activity discovered in seated rest data, as well as with the performance of classifiers trained on event-related changes in physiological activity. Granularity was also positively associated with RSA during seated rest periods, although this relationship did not reach significance in this sample. These findings are consistent with constructionist accounts of emotion that propose concepts as a key mechanism underlying individual differences in emotional experience, physiological regulation, and physical health.
C1 [Hoemann, Katie] Katholieke Univ Leuven, Dept Psychol, Leuven, Belgium.
   [Khan, Zulqarnain; Dy, Jennifer] Northeastern Univ, Dept Elect & Comp Engn, Boston, MA 02115 USA.
   [Kamona, Nada; Barrett, Lisa Feldman; Quigley, Karen S.] Northeastern Univ, Dept Psychol, Boston, MA 02115 USA.
   [Barrett, Lisa Feldman] Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02115 USA.
   [Barrett, Lisa Feldman] Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA.
   [Quigley, Karen S.] Edith Nourse Rogers Mem Vet Hosp, Ctr Healthcare Org & Implementat Res, Bedford, MA USA.
C3 KU Leuven; Northeastern University; Northeastern University; Harvard
   University; Harvard Medical School; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Harvard University; Harvard
   University Medical Affiliates; Massachusetts General Hospital
RP Hoemann, K (corresponding author), Katholieke Univ Leuven, Dept Psychol, Leuven, Belgium.
EM khoemann@gmail.com
RI Barrett, Lisa/ABC-8157-2020; Hoemann, Katie/J-6320-2019; Quigley,
   Karen/B-9003-2013
OI Quigley, Karen/0000-0001-8844-990X; Kamona, Nada/0000-0002-4382-876X;
   Barrett, Lisa/0000-0003-4478-2051
FU National Heart, Lung, and Blood Institute [1F31HL140943-01]; P.E.O.
   International Scholar Award; U.S. Army Research Institute for the
   Behavioral and Social Sciences [W911NF-16-1-0191]
FX This work was performed at Northeastern University in partial
   fulfillment of a Doctor of Philosophy Degree in Psychology awarded to
   Katie Hoemann. K.H. was supported by the National Heart, Lung, and Blood
   Institute (grant number 1F31HL140943-01) and a P.E.O. International
   Scholar Award. This work was further supported by the U.S. Army Research
   Institute for the Behavioral and Social Sciences (grant number
   W911NF-16-1-0191 to K.S.Q. and Dr. Jolie Wormwood, Co-PIs). The views,
   opinions, and/or findings contained in this paper are those of the
   authors and shall not be construed as an official Department of the Army
   position, policy, or decision, unless so designated by other documents.
CR Acharya UR, 2006, MED BIOL ENG COMPUT, V44, P1031, DOI 10.1007/s11517-006-0119-0
   AKSELROD S, 1985, AM J PHYSIOL, V249, pH867, DOI 10.1152/ajpheart.1985.249.4.H867
   Altman N, 2016, NAT METHODS, V13, P281, DOI 10.1038/nmeth.3812
   Anand D, 2017, DRUG ALCOHOL DEPEN, V180, P439, DOI 10.1016/j.drugalcdep.2017.09.007
   Appelhans BM, 2006, REV GEN PSYCHOL, V10, P229, DOI 10.1037/1089-2680.10.3.229
   Aune D, 2017, NUTR METAB CARDIOVAS, V27, P504, DOI 10.1016/j.numecd.2017.04.004
   Balzarotti S, 2017, BIOL PSYCHOL, V130, P54, DOI 10.1016/j.biopsycho.2017.10.008
   Barrett L.F., 2014, Handbook of emotion regulation, P447
   Barrett L.F., 2015, PSYCHOL CONSTRUCTION
   Barrett LF, 2004, J PERS SOC PSYCHOL, V87, P684, DOI 10.1037/0022-3514.87.5.684
   Barrett LF, 2001, COGNITION EMOTION, V15, P713, DOI 10.1080/02699930143000239
   Barrett LF, 2006, PERSPECT PSYCHOL SCI, V1, P28, DOI 10.1111/j.1745-6916.2006.00003.x
   Barrett LF, 2017, SOC COGN AFFECT NEUR, V12, P1, DOI [10.1093/scan/nsw154, 10.1093/scan/nsx060]
   Barrett LF, 2015, NAT REV NEUROSCI, V16, P419, DOI 10.1038/nrn3950
   Barrett LF, 2013, EMOT REV, V5, P379, DOI 10.1177/1754073913489753
   Barrett LF, 2012, EMOTION, V12, P413, DOI 10.1037/a0027555
   Barrett Lisa Feldman., 2017, How emotions are made: The secret life of the brain
   Bauer DJ, 2007, MULTIVAR BEHAV RES, V42, P757, DOI 10.1080/00273170701710338
   Bauer DJ, 2003, PSYCHOL METHODS, V8, P338, DOI 10.1037/1082-989X.8.3.338
   Beauchaine T, 2001, DEV PSYCHOPATHOL, V13, P183, DOI 10.1017/S0954579401002012
   Beauchaine TP, 2015, CURR OPIN PSYCHOL, V3, P43, DOI 10.1016/j.copsyc.2015.01.017
   Beresnevaite M, 2000, PSYCHOTHER PSYCHOSOM, V69, P117, DOI 10.1159/000012378
   Berntson GG, 2004, PSYCHOPHYSIOLOGY, V41, P333, DOI 10.1111/j.1469-8986.2004.00156.x
   BERNTSON GG, 1990, PSYCHOPHYSIOLOGY, V27, P586, DOI 10.1111/j.1469-8986.1990.tb01982.x
   BERNTSON GG, 1993, PSYCHOPHYSIOLOGY, V30, P183, DOI 10.1111/j.1469-8986.1993.tb01731.x
   BERNTSON GG, 1994, PSYCHOPHYSIOLOGY, V31, P572, DOI 10.1111/j.1469-8986.1994.tb02350.x
   BISHOP C. M., 2006, PATTERN RECOGN
   Blascovich J., 2001, Feeling and Thinking: The Role of Affect in Social Cognition, Studies in Emotion and Social Interaction, P59
   Blei DM, 2006, BAYESIAN ANAL, V1, P121, DOI 10.1214/06-BA104
   Bleil ME, 2008, PSYCHOSOM MED, V70, P328, DOI 10.1097/PSY.0b013e31816baefa
   Bleyer AJ, 2011, RESUSCITATION, V82, P1387, DOI 10.1016/j.resuscitation.2011.06.033
   Böhm M, 2015, AM J MED, V128, P219, DOI 10.1016/j.amjmed.2014.09.016
   Buccelletti F, 2009, EUR REV MED PHARMACO, V13, P299
   CACIOPPO JT, 1994, PSYCHOPHYSIOLOGY, V31, P586, DOI 10.1111/j.1469-8986.1994.tb02351.x
   Cameron CD, 2013, J EXP SOC PSYCHOL, V49, P719, DOI 10.1016/j.jesp.2013.02.014
   Camm AJ, 1996, CIRCULATION, V93, P1043
   Carnevali L, 2018, INT J PSYCHOPHYSIOL, V131, P131, DOI 10.1016/j.ijpsycho.2017.11.002
   Carney RM, 2005, PSYCHOSOM MED, V67, pS29, DOI 10.1097/01.psy.0000162254.61556.d5
   Carreiras C., 2015, BioSPPy: Biosignal Processing in Python Network
   Chalmers JA, 2014, FRONT PSYCHIATRY, V5, DOI 10.3389/fpsyt.2014.00080
   Chanes L, 2016, TRENDS COGN SCI, V20, P96, DOI 10.1016/j.tics.2015.11.005
   Cohen H, 2000, PSYCHIAT RES, V96, P1, DOI 10.1016/S0165-1781(00)00195-5
   COOK RD, 1977, TECHNOMETRICS, V19, P15, DOI 10.2307/1268249
   Dalgleish T, 2007, J EXP PSYCHOL GEN, V136, P23, DOI 10.1037/0096-3445.136.1.23
   Dasch KB, 2010, J BEHAV MED, V33, P441, DOI 10.1007/s10865-010-9274-8
   de Geus EJC, 2019, PSYCHOPHYSIOLOGY, V56, DOI 10.1111/psyp.13287
   DEGEUS EJC, 1995, BIOL PSYCHOL, V41, P205, DOI 10.1016/0301-0511(95)05137-6
   Demiralp E, 2012, PSYCHOL SCI, V23, P1410, DOI 10.1177/0956797612444903
   Dixon-Gordon KL, 2014, J PSYCHOPATHOL BEHAV, V36, P616, DOI 10.1007/s10862-014-9423-4
   Edwards ER, 2017, DEVIANT BEHAV, V38, P1160, DOI 10.1080/01639625.2016.1241066
   Erbas Y, 2018, J PERS SOC PSYCHOL, V115, P179, DOI 10.1037/pspa0000126
   Erbas Y, 2014, COGNITION EMOTION, V28, P1196, DOI 10.1080/02699931.2013.875890
   Erbas Y, 2013, RES AUTISM SPECT DIS, V7, P1221, DOI 10.1016/j.rasd.2013.07.007
   Ernst JM, 1999, PSYCHOPHYSIOLOGY, V36, P333, DOI 10.1017/S0048577299981003
   Faul F, 2009, BEHAV RES METHODS, V41, P1149, DOI 10.3758/BRM.41.4.1149
   Forouzanfar M, 2018, PSYCHOPHYSIOLOGY, V55, DOI 10.1111/psyp.13072
   Fox K, 2007, J AM COLL CARDIOL, V50, P823, DOI 10.1016/j.jacc.2007.04.079
   Garfinkel SN, 2015, BIOL PSYCHOL, V104, P65, DOI 10.1016/j.biopsycho.2014.11.004
   Geisler FCM, 2010, PERS INDIV DIFFER, V49, P723, DOI 10.1016/j.paid.2010.06.015
   Gianaros PJ, 2018, AM PSYCHOL, V73, P1031, DOI 10.1037/amp0000232
   Grippo AJ, 2002, NEUROSCI BIOBEHAV R, V26, P941, DOI 10.1016/S0149-7634(03)00003-4
   GROSSMAN P, 1991, PSYCHOPHYSIOLOGY, V28, P201, DOI 10.1111/j.1469-8986.1991.tb00412.x
   Hamilton JL, 2017, CLIN PSYCHOL SCI, V5, P911, DOI 10.1177/2167702617720211
   Hamilton P, 2002, COMPUT CARDIOL, V29, P101, DOI 10.1109/CIC.2002.1166717
   Harrison NA, 2009, BIOL PSYCHIAT, V66, P415, DOI 10.1016/j.biopsych.2009.03.007
   Harrison NA, 2009, BIOL PSYCHIAT, V66, P407, DOI 10.1016/j.biopsych.2009.03.015
   Herbert BM, 2011, J PERS, V79, P1149, DOI 10.1111/j.1467-6494.2011.00717.x
   Hill LK, 2015, PSYCHOSOM MED, V77, P16, DOI 10.1097/PSY.0000000000000133
   Hoemann K, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-69180-y
   Hoemann K, 2017, CURR OPIN BEHAV SCI, V15, P51, DOI 10.1016/j.cobeha.2017.05.013
   Hohwy J., 2013, PREDICTIVE MIND
   Kahneman D, 2004, SCIENCE, V306, P1776, DOI 10.1126/science.1103572
   Kalokerinos EK, 2019, PSYCHOL SCI, V30, P863, DOI 10.1177/0956797619838763
   Kapczinski F, 2008, NEUROSCI BIOBEHAV R, V32, P675, DOI 10.1016/j.neubiorev.2007.10.005
   Kashdan TB, 2015, CURR DIR PSYCHOL SCI, V24, P10, DOI 10.1177/0963721414550708
   Kashdan TB, 2014, EMOTION, V14, P629, DOI 10.1037/a0035796
   Kashdan TB, 2010, PSYCHOL SCI, V21, P1341, DOI 10.1177/0956797610379863
   Kemp AH, 2013, INT J PSYCHOPHYSIOL, V89, P288, DOI 10.1016/j.ijpsycho.2013.06.018
   Kemp AH, 2010, BIOL PSYCHIAT, V67, P1067, DOI [10.1016/j.biopsych.2009.12.012, 10.1016/j.biopsych.2009.11.019]
   Kimhy D, 2014, J PSYCHIATR RES, V53, P141, DOI 10.1016/j.jpsychires.2014.01.020
   Kinnunen ML, 2005, J PSYCHOSOM RES, V58, P513, DOI 10.1016/j.jpsychores.2005.02.004
   Kleckner IR, 2017, NAT HUM BEHAV, V1, DOI 10.1038/s41562-017-0069
   Koenig J, 2016, CLIN PSYCHOL REV, V46, P136, DOI 10.1016/j.cpr.2016.04.013
   Kogan A, 2014, J PERS SOC PSYCHOL, V107, P1051, DOI 10.1037/a0037509
   Kogan A, 2013, EMOTION, V13, P599, DOI 10.1037/a0032725
   Koval P, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0081536
   Krantz DS, 2002, ANNU REV PSYCHOL, V53, P341, DOI 10.1146/annurev.psych.53.100901.135208
   Lane R.D., 2005, J NEURO PSYCHOANALYS, V7, P5, DOI [10.1080/15294145.2005.10773468, DOI 10.1080/15294145.2005.10773468]
   LANE RD, 1987, AM J PSYCHIAT, V144, P133
   Lane RD, 1997, BIOL PSYCHIAT, V42, P834, DOI 10.1016/S0006-3223(97)00050-4
   Lane RD, 2009, NEUROIMAGE, V44, P213, DOI 10.1016/j.neuroimage.2008.07.056
   Lecours S, 2009, EUR REV APPL PSYCHOL, V59, P187, DOI 10.1016/j.erap.2009.03.001
   Lee JY, 2017, FRONT HUM NEUROSCI, V11, P1, DOI 10.3389/fnhum.2017.00133
   Lindquist KA, 2012, BEHAV BRAIN SCI, V35, P121, DOI 10.1017/S0140525X11000446
   LLABRE MM, 1991, PSYCHOPHYSIOLOGY, V28, P701, DOI 10.1111/j.1469-8986.1991.tb01017.x
   Meganck R, 2009, PERS INDIV DIFFER, V47, P990, DOI 10.1016/j.paid.2009.08.005
   Mulcahy JS, 2019, NEUROIMAGE, V202, DOI 10.1016/j.neuroimage.2019.116072
   Myrtek Michael., 1985, Clinical and methodological issues in cardiovascular psychophysiology, P93
   Nabian M, 2018, IEEE J TRANSL ENG HE, V6, DOI 10.1109/JTEHM.2018.2878000
   NEMIAH JC, 1970, PSYCHOTHER PSYCHOSOM, V18, P154, DOI 10.1159/000286074
   Palatini P, 2007, DRUGS, V67, P3, DOI 10.2165/00003495-200767002-00002
   POMERANZ B, 1985, AM J PHYSIOL, V248, pH151, DOI 10.1152/ajpheart.1985.248.1.H151
   Pond RS, 2012, EMOTION, V12, P326, DOI 10.1037/a0025762
   QU MH, 1986, IEEE T BIO-MED ENG, V33, P1029, DOI 10.1109/TBME.1986.325869
   Quigley KS, 2014, BIOL PSYCHOL, V98, P82, DOI 10.1016/j.biopsycho.2013.12.013
   Raichle ME, 2015, PHILOS T R SOC B, V370, P82, DOI 10.1098/rstb.2014.0172
   Roedema TM, 1999, PSYCHOPHYSIOLOGY, V36, P379, DOI 10.1017/S0048577299980290
   Rozanski A, 2014, J AM COLL CARDIOL, V64, P100, DOI 10.1016/j.jacc.2014.03.047
   SCHANDRY R, 1981, PSYCHOPHYSIOLOGY, V18, P483, DOI 10.1111/j.1469-8986.1981.tb02486.x
   Schneider S, 2020, J MED INTERNET RES, V22, DOI 10.2196/19201
   Seah THS, 2020, BEHAV THER, V51, P135, DOI 10.1016/j.beth.2019.05.011
   Seery MD, 2011, NEUROSCI BIOBEHAV R, V35, P1603, DOI 10.1016/j.neubiorev.2011.03.003
   Selby EA, 2014, CLIN PSYCHOL SCI, V2, P514, DOI 10.1177/2167702613512794
   Sheps DS, 2001, J CLIN PSYCHIAT, V62, P12
   SHROUT PE, 1979, PSYCHOL BULL, V86, P420, DOI 10.1037/0033-2909.86.2.420
   Sloan RP, 2017, HEALTH PSYCHOL, V36, P73, DOI 10.1037/hea0000397
   Smidt KE, 2015, CURR OPIN PSYCHOL, V3, P48, DOI 10.1016/j.copsyc.2015.02.007
   Starr LR, 2017, CLIN PSYCHOL SCI, V5, P613, DOI 10.1177/2167702617694657
   Stein PK, 2007, DIABETIC MED, V24, P855, DOI 10.1111/j.1464-5491.2007.02163.x
   Stein PK, 2005, J CARDIOVASC ELECTR, V16, P13, DOI 10.1046/j.1540-8167.2005.04358.x
   Stein PK, 2000, J PSYCHOSOM RES, V48, P493, DOI 10.1016/S0022-3999(99)00085-9
   Sterling P, 2012, PHYSIOL BEHAV, V106, P5, DOI 10.1016/j.physbeh.2011.06.004
   Stone AA, 2006, EMOTION, V6, P139, DOI 10.1037/1528-3542.6.1.139
   Suvak MK, 2011, J ABNORM PSYCHOL, V120, P414, DOI 10.1037/a0021808
   Thayer JF, 1996, BIOL PSYCHIAT, V39, P255, DOI 10.1016/0006-3223(95)00136-0
   Thayer JF, 2000, J AFFECT DISORDERS, V61, P201, DOI 10.1016/S0165-0327(00)00338-4
   Thayer JF, 2012, NEUROSCI BIOBEHAV R, V36, P747, DOI 10.1016/j.neubiorev.2011.11.009
   Thayer JF, 2010, INT J CARDIOL, V141, P122, DOI 10.1016/j.ijcard.2009.09.543
   Thayer JF, 2009, NEUROSCI BIOBEHAV R, V33, P81, DOI 10.1016/j.neubiorev.2008.08.004
   Togo F, 2009, IND HEALTH, V47, P589, DOI 10.2486/indhealth.47.589
   TOMAKA J, 1993, J PERS SOC PSYCHOL, V65, P248, DOI 10.1037/0022-3514.65.2.248
   Tomko RL, 2015, J ABNORM PSYCHOL, V124, P740, DOI 10.1037/abn0000064
   Trull TJ, 2015, EMOT REV, V7, P355, DOI 10.1177/1754073915590617
   Tugade Michele M, 2004, J Pers, V72, P1161
   Van der Gucht K, 2019, EMOTION, V19, P123, DOI 10.1037/emo0000406
   van Roon AM, 2016, HYPERTENSION, V68, pE63, DOI 10.1161/HYPERTENSIONAHA.116.08053
   Villareal Rollo P, 2002, Curr Atheroscler Rep, V4, P120, DOI 10.1007/s11883-002-0035-1
   Wang YL, 2020, PSYCHOPHYSIOLOGY, V57, DOI 10.1111/psyp.13690
   Warriner AB, 2013, BEHAV RES METHODS, V45, P1191, DOI 10.3758/s13428-012-0314-x
   WHITEHEAD WE, 1977, BIOFEEDBACK SELF-REG, V2, P371, DOI 10.1007/BF00998623
   Widdershoven RLA, 2019, J AFFECT DISORDERS, V244, P71, DOI 10.1016/j.jad.2018.10.092
   Wilhelm FH, 2010, BIOL PSYCHOL, V84, P552, DOI 10.1016/j.biopsycho.2010.01.017
   Willroth EC, 2020, J PERS, V88, P174, DOI 10.1111/jopy.12475
   Wilson-Mendenhall CD, 2015, SOC COGN AFFECT NEUR, V10, P62, DOI 10.1093/scan/nsu037
   Wilson-Mendenhall CD, 2011, NEUROPSYCHOLOGIA, V49, P1105, DOI 10.1016/j.neuropsychologia.2010.12.032
   Wormwood JB, 2019, PSYCHOPHYSIOLOGY, V56, DOI 10.1111/psyp.13454
   Yancura LA, 2006, J GERONTOL B-PSYCHOL, V61, pP295, DOI 10.1093/geronb/61.5.P295
NR 147
TC 19
Z9 24
U1 6
U2 39
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0048-5772
EI 1469-8986
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD JUN
PY 2021
VL 58
IS 6
AR e13818
DI 10.1111/psyp.13818
EA MAR 2021
PG 18
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
   Psychology, Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Neurosciences & Neurology; Physiology
GA SK5UD
UT WOS:000632679100001
PM 33768687
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Dabek, J
   Wilczok, T
   Gasior, Z
   Kucia-Kuzma, S
   Twardowski, R
   Kulach, A
AF Dabek, Jozefa
   Wilczok, Tadeusz
   Gasior, Zbigniew
   Kucia-Kuzma, Sylwia
   Twardowski, Romuald
   Kulach, Andrzej
TI Gene expression of kinin receptors B1 and B2 in PBMC from patients with
   cardiac syndrome X
SO SCANDINAVIAN CARDIOVASCULAR JOURNAL
LA English
DT Article
DE cardiac syndrome X; kinin receptors; gene expression; mononuclear cells
ID LEFT-VENTRICULAR FUNCTION; CORONARY-ARTERY; B-1 RECEPTORS; BRADYKININ;
   DISEASE; INFLAMMATION; PROGNOSIS; COMPLEX; SYSTEM; CELLS
AB Introduction. Cardiac syndrome X (CSX) is defined by typical chest pain, ST segment depression on ECG and normal coronary angiography. Pathology of CSX may involve microvascular dysfunction related to inflammation and abnormal pain sensitivity. Kinins are labile peptides participating in vasodilation, inflammation and pain. Their effects are mediated by two receptors: B1 and B2. The aim of the study was to assess gene expression of kinin receptors in peripheral blood mononuclear cells (PBMC) from patients with CSX. Methods. The study was carried out in 34 patients with cardiac syndrome X, 13 with unstable angina and ten healthy subjects. Total mRNA was extracted from PBMC and the number of mRNA copies was assessed by quantitive reverse transcriptase polymerase chain reaction. Results and Conclusion. The study showed 7-fold higher transcriptional activity of B1R in CSX vs. control and 3.5 higher vs. UA. B2R expression was 2.5-fold higher in CSX group vs. control and UA, while in the letter two groups it was similar. Such disturbance in kinin signaling may participate in local vasoconstriction and may reflect disturbances in kinin signaling leading to nociceptive disturbances in these patients.
C1 L Warynski Silesian Med Acad, Dept Cardiol, PL-40635 Katowice, Poland.
   L Warynski Silesian Med Acad, Dept Mol Biol & Med Genet, Sosnowiec, Poland.
C3 Medical University of Silesia; Medical University of Silesia
RP Kulach, A (corresponding author), L Warynski Silesian Med Acad, Dept Cardiol, Ziolowa 47, PL-40635 Katowice, Poland.
EM akulach@mp.pl
RI Kulach, Andrzej/ABF-3313-2020
OI Gasior, Zbigniew/0000-0003-3616-8932; Dabek, Jozefa/0000-0002-8257-6614;
   Kulach, Andrzej/0000-0002-3140-1806
CR Calixto JB, 2004, BRIT J PHARMACOL, V143, P803, DOI 10.1038/sj.bjp.0706012
   Chen ZL, 2006, FASEB J, V20, P2261, DOI 10.1096/fj.06-6113com
   Coelho MM, 1997, BRIT J PHARMACOL, V121, P296, DOI 10.1038/sj.bjp.0701110
   Couture R, 2001, EUR J PHARMACOL, V429, P161, DOI 10.1016/S0014-2999(01)01318-8
   DRUMMOND GR, 1995, BRIT J PHARMACOL, V116, P2473, DOI 10.1111/j.1476-5381.1995.tb15098.x
   Johnson BD, 2004, CIRCULATION, V109, P2993, DOI 10.1161/01.CIR.0000130642.79868.B2
   KASKI JC, 1995, J AM COLL CARDIOL, V25, P807, DOI 10.1016/0735-1097(94)00507-M
   KEMP HG, 1973, AM J CARDIOL, V32, P375, DOI 10.1016/S0002-9149(73)80150-X
   KOLODZIEJ K, 2001, FORUM KARDIOL, V4, P1425
   Lanza GA, 2002, HEART, V88, P328, DOI 10.1136/heart.88.4.328
   Leu HB, 2006, FREE RADICAL BIO MED, V40, P983, DOI 10.1016/j.freeradbiomed.2005.10.047
   Lin CP, 2003, INT J CARDIOL, V89, P53, DOI 10.1016/S0167-5273(02)00428-X
   MARCEAU F, 1995, IMMUNOPHARMACOLOGY, V30, P1, DOI 10.1016/0162-3109(95)00011-H
   McLean PG, 2000, CARDIOVASC RES, V48, P194, DOI 10.1016/S0008-6363(00)00184-X
   Moreau ME, 2005, J PHARMACOL SCI, V99, P6, DOI 10.1254/jphs.SRJ05001X
   PAEGELOW I, 1995, EUR J PHARMACOL, V279, P211, DOI 10.1016/0014-2999(95)00154-D
   Panting JR, 2002, NEW ENGL J MED, V346, P1948, DOI 10.1056/NEJMoa012369
   Raidoo DM, 1997, IMMUNOPHARMACOLOGY, V36, P153, DOI 10.1016/S0162-3109(97)00015-5
   Rajasekariah P, 1997, BIOCHEM MOL BIOL INT, V43, P279
   ROGACKA D, 2003, FOLIA CARDIOL, V10, P553
   Rosen SD, 2002, HEART, V87, P513, DOI 10.1136/heart.87.6.513
   TYMINSKASEDEK K, 2002, TERAPIA, V9
   Vázquez-Rey E, 2003, REV ESP CARDIOL, V56, P181, DOI 10.1157/13043225
   Yang XP, 2001, CIRC RES, V88, P1072, DOI 10.1161/hh1001.090759
NR 24
TC 7
Z9 7
U1 0
U2 0
PU TAYLOR & FRANCIS AS
PI OSLO
PA PO BOX 12 POSTHUSET, NO-0051 OSLO, NORWAY
SN 1401-7431
J9 SCAND CARDIOVASC J
JI Scand. Cardiovasc. J.
PY 2007
VL 41
IS 6
BP 391
EP 396
DI 10.1080/14017430701499379
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 234EJ
UT WOS:000251143200007
PM 17852785
DA 2025-06-11
ER

PT J
AU Derry, HM
   Fagundes, CP
   Andridge, R
   Glaser, R
   Malarkey, WB
   Kiecolt-Glaser, JK
AF Derry, Heather M.
   Fagundes, Christopher P.
   Andridge, Rebecca
   Glaser, Ronald
   Malarkey, William B.
   Kiecolt-Glaser, Janice K.
TI Lower subjective social status exaggerates interleukin-6 responses to a
   laboratory stressor
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Subjective social status; Inflammation; Interleukin-6 (IL-6); Laboratory
   stressor
ID INDUCED INFLAMMATORY RESPONSES; LPS-INDUCED CYTOKINE;
   SOCIOECONOMIC-STATUS; CARDIOVASCULAR REACTIVITY; DEPRESSIVE SYMPTOMS;
   CORTISOL RESPONSES; INSULIN-RESISTANCE; METABOLIC SYNDROME; INDUCED
   INCREASES; MAJOR DEPRESSION
AB Growing evidence suggests that lower subjective social status (SSS), which reflects where a person positions himself on a social ladder in relation to others, is independently related to poor health. People who rate themselves lower in status also experience more frequent stressors and report higher stress than those who rate themselves higher in status, and chronic stress can enhance an individual's response to subsequent stressors. To address whether SSS predicted stress-induced interleukin-6 (IL-6) changes, we assessed 138 healthy adults at rest and following the Trier Social Stress Test (TSST). Participants completed the TSST at two study visits, separated by 4 months. People who placed themselves lower on the social ladder had larger IL-6 responses from baseline to 45 min post-stressor (p = 0.01) and from baseline to 2 h post-stressor (p = 0.03) than those who placed themselves higher on the social ladder. Based on a ratio of subjective threat and coping ratings of the stress task, participants who viewed themselves as lower in status also tended to rate the speech task as more threatening and less manageable than those who viewed themselves as higher in status (p = 0.05). These data suggest that people with tower perceived status experience greater physiological and psychological burden from brief stressors compared to those with higher perceived status. Accordingly, responses to stressors may be a possible mechanistic link among SSS, stress, and health. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Derry, Heather M.; Glaser, Ronald; Malarkey, William B.; Kiecolt-Glaser, Janice K.] Ohio State Univ, Coll Med, Inst Behav Med Res, Columbus, OH 43210 USA.
   [Derry, Heather M.; Kiecolt-Glaser, Janice K.] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA.
   [Fagundes, Christopher P.] Univ Texas MD Anderson Canc Ctr, Dept Hlth Dispar Res, Houston, TX 77030 USA.
   [Andridge, Rebecca] Ohio State Univ, Coll Publ Hlth, Div Biostat, Columbus, OH 43210 USA.
   [Glaser, Ronald; Malarkey, William B.] Ohio State Univ, Coll Med, Dept Internal Med, Columbus, OH 43210 USA.
   [Glaser, Ronald] Ohio State Univ, Coll Med, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA.
   [Glaser, Ronald; Malarkey, William B.; Kiecolt-Glaser, Janice K.] Ohio State Univ, Coll Med, Ctr Comprehens Canc, Columbus, OH 43210 USA.
   [Kiecolt-Glaser, Janice K.] Ohio State Univ, Coll Med, Dept Psychiat, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University; University of Texas System; UTMD Anderson
   Cancer Center; University System of Ohio; Ohio State University;
   University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University; James Cancer Hospital & Solove Research
   Institute; University System of Ohio; Ohio State University; University
   System of Ohio; Ohio State University
RP Derry, HM (corresponding author), Ohio State Univ, Coll Med, Inst Behav Med Res, 460 Med Ctr Dr, Columbus, OH 43210 USA.
EM Heather.Derry@osumc.edu
RI ; Andridge, Rebecca/C-8457-2012
OI Derry-Vick, Heather/0000-0003-0753-0859; Andridge,
   Rebecca/0000-0001-9991-9647
FU NIH [AG029562, AG038621, UL1TR000090, CA16058]; S. Robert Davis
   endowment; Kathryn a Gilbert Mitchell endowment; American Cancer Society
   [PF-11-007-01-CPPB]
FX Work on this project was supported in part by NIH Grants AG029562,
   AG038621, UL1TR000090, CA16058, the S. Robert Davis endowment, the
   Kathryn a Gilbert Mitchell endowment, and American Cancer Society
   Postdoctoral Fellowship Grant PF-11-007-01-CPPB. OmegaBrite (Waltham,
   MA) supplied the omega-3 supplement and placebo without charge and
   without restrictions. OmegaBrite did not influence the design, funding,
   implementation, interpretation, or publication of the data.
CR Adler N, 2008, SOC SCI MED, V66, P1034, DOI 10.1016/j.socscimed.2007.11.031
   Adler NE, 2000, HEALTH PSYCHOL, V19, P586, DOI 10.1037/0278-6133.19.6.586
   ADLER NE, 1994, AM PSYCHOL, V49, P15, DOI 10.1037/0003-066X.49.1.15
   [Anonymous], 1998, Manual for the Childhood Trauma Questionnaire
   Barnes PJ, 1998, CLIN SCI, V94, P557, DOI 10.1042/cs0940557
   Basco MR, 1997, MEASURING PATIENT CH, P207, DOI DOI 10.1037/10232-007
   Black PH, 2003, BRAIN BEHAV IMMUN, V17, P350, DOI 10.1016/S0889-1591(03)00048-5
   Brydon L, 2005, J HYPERTENS, V23, P1001, DOI 10.1097/01.hjh.0000166841.57474.d0
   Brydon L, 2004, BRAIN BEHAV IMMUN, V18, P281, DOI 10.1016/j.bbi.2003.09.011
   Cesari M, 2012, J GERONTOL A-BIOL, V67, P671, DOI 10.1093/gerona/glr246
   Chapman BP, 2009, BRAIN BEHAV IMMUN, V23, P636, DOI 10.1016/j.bbi.2008.12.009
   Cohen S, 2008, HEALTH PSYCHOL, V27, P268, DOI 10.1037/0278-6133.27.2.268
   Coussens LM, 2002, NATURE, V420, P860, DOI 10.1038/nature01322
   Demakakos P, 2008, SOC SCI MED, V67, P330, DOI 10.1016/j.socscimed.2008.03.038
   Dickerson SS, 2004, PSYCHOL BULL, V130, P355, DOI 10.1037/0033-2909.130.3.355
   Ershler WB, 2000, ANNU REV MED, V51, P245, DOI 10.1146/annurev.med.51.1.245
   Fagundes CP, 2013, BRAIN BEHAV IMMUN, V31, P172, DOI 10.1016/j.bbi.2012.05.006
   Fagundes CP, 2013, BRAIN BEHAV IMMUN, V27, P8, DOI 10.1016/j.bbi.2012.06.014
   Festinger L, 1954, HUM RELAT, V7, P117, DOI 10.1177/001872675400700202
   Friedman EM, 2010, PSYCHOSOM MED, V72, P290, DOI 10.1097/PSY.0b013e3181cfe4c2
   Glaser R, 2003, ARCH GEN PSYCHIAT, V60, P1009, DOI 10.1001/archpsyc.60.10.1009
   Gruenewald TL, 2006, BRAIN BEHAV IMMUN, V20, P410, DOI 10.1016/j.bbi.2005.11.005
   Gump BB, 1999, HEALTH PSYCHOL, V18, P140, DOI 10.1037/0278-6133.18.2.140
   Heffner KL, 2002, INT J PSYCHOPHYSIOL, V44, P165, DOI 10.1016/S0167-8760(01)00200-8
   Hu PF, 2005, J AM GERIATR SOC, V53, P483, DOI 10.1111/j.1532-5415.2005.53169.x
   Johnson JD, 2003, AM J PHYSIOL-REG I, V284, pR422, DOI 10.1152/ajpregu.00230.2002
   Johnson JD, 2002, BRAIN BEHAV IMMUN, V16, P461, DOI 10.1006/brbi.2001.0638
   Kenward MG, 1997, BIOMETRICS, V53, P983, DOI 10.2307/2533558
   Kiecolt-Glaser JK, 2012, BRAIN BEHAV IMMUN, V26, P988, DOI 10.1016/j.bbi.2012.05.011
   Kiecolt-Glaser JK, 2009, PSYCHONEUROENDOCRINO, V34, P670, DOI 10.1016/j.psyneuen.2008.11.010
   Kiecolt-Glaser JK, 2005, ARCH GEN PSYCHIAT, V62, P1377, DOI 10.1001/archpsyc.62.12.1377
   Kiecolt-Glaser JK, 2003, P NATL ACAD SCI USA, V100, P9090, DOI 10.1073/pnas.1531903100
   KIRSCHBAUM C, 1993, NEUROPSYCHOBIOLOGY, V28, P76, DOI 10.1159/000119004
   Krabbe KS, 2004, EXP GERONTOL, V39, P687, DOI 10.1016/j.exger.2004.01.009
   Lazarus R. S., 1984, Stress, appraisal, and coping, DOI [10.1007/978-3-030-39903-0_215, DOI 10.1007/978-1-4419-1005-9_215]
   Lemeshow AR, 2008, ARCH PEDIAT ADOL MED, V162, P23, DOI 10.1001/archpediatrics.2007.11
   Libby P, 2007, NUTR REV, V65, pS140, DOI 10.1301/nr.2007.dec.S140-S146
   Loucks EB, 2006, AM J EPIDEMIOL, V163, P622, DOI 10.1093/aje/kwj076
   Maes M, 2001, J AFFECT DISORDERS, V63, P85, DOI 10.1016/S0165-0327(00)00156-7
   Maggio M, 2006, J GERONTOL A-BIOL, V61, P575, DOI 10.1093/gerona/61.6.575
   Manuck SB, 2010, PSYCHOSOM MED, V72, P35, DOI 10.1097/PSY.0b013e3181c484dc
   Marshall GD, 1998, BRAIN BEHAV IMMUN, V12, P297, DOI 10.1006/brbi.1998.0537
   McEwen BS, 1998, ANN NY ACAD SCI, V840, P33, DOI 10.1111/j.1749-6632.1998.tb09546.x
   Nobles J, 2013, SOC SCI MED, V82, P58, DOI 10.1016/j.socscimed.2013.01.021
   Operario D, 2004, PSYCHOL HEALTH, V19, P237, DOI 10.1080/08870440310001638098
   Ostrove JM, 2000, HEALTH PSYCHOL, V19, P613, DOI 10.1037/0278-6133.19.6.613
   Pace TWW, 2006, AM J PSYCHIAT, V163, P1630, DOI 10.1176/appi.ajp.163.9.1630
   Pedersen BK, 2008, PHYSIOL REV, V88, P1379, DOI 10.1152/physrev.90100.2007
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Reitzel LR, 2007, AM J PUBLIC HEALTH, V97, P1476, DOI 10.2105/AJPH.2006.101295
   Reuben DB, 2002, J AM GERIATR SOC, V50, P638, DOI 10.1046/j.1532-5415.2002.50157.x
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Singh-Manoux A, 2005, PSYCHOSOM MED, V67, P855, DOI 10.1097/01.psy.0000188434.52941.a0
   Singh-Manoux A, 2003, SOC SCI MED, V56, P1321, DOI 10.1016/S0277-9536(02)00131-4
   Steptoe A, 2003, PSYCHOSOM MED, V65, P137, DOI 10.1097/01.PSY.0000039755.23250.A7
   Steptoe A, 2002, BRAIN BEHAV IMMUN, V16, P774, DOI 10.1016/S0889-1591(02)00030-2
   Steptoe A, 2007, BRAIN BEHAV IMMUN, V21, P901, DOI 10.1016/j.bbi.2007.03.011
   Stowe RP, 2010, J GERONTOL A-BIOL, V65, P429, DOI 10.1093/gerona/glp198
   Suls J, 2002, CURR DIR PSYCHOL SCI, V11, P159, DOI 10.1111/1467-8721.00191
   Taylor SE, 1999, ANN NY ACAD SCI, V896, P210, DOI 10.1111/j.1749-6632.1999.tb08117.x
   TOMAKA J, 1993, J PERS SOC PSYCHOL, V65, P248, DOI 10.1037/0022-3514.65.2.248
   Walker EA, 1999, ARCH GEN PSYCHIAT, V56, P609, DOI 10.1001/archpsyc.56.7.609
   WINKLEBY MA, 1992, AM J PUBLIC HEALTH, V82, P816, DOI 10.2105/AJPH.82.6.816
NR 63
TC 75
Z9 83
U1 0
U2 28
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD NOV
PY 2013
VL 38
IS 11
BP 2676
EP 2685
DI 10.1016/j.psyneuen.2013.06.026
PG 10
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 268MT
UT WOS:000328175700028
PM 23849596
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hough, CM
   Bersani, FS
   Mellon, SH
   Morford, AE
   Lindqvist, D
   Reus, VI
   Epel, ES
   Wolkowitz, OM
AF Hough, Christina M.
   Bersani, F. Saverio
   Mellon, Synthia H.
   Morford, Alexandra E.
   Lindqvist, Daniel
   Reus, Victor I.
   Epel, Elissa S.
   Wolkowitz, Owen M.
TI Pre-treatment allostatic load and metabolic dysregulation predict SSRI
   response in major depressive disorder: a preliminary report
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Allostatic load; antidepressant response; major depressive disorder;
   metabolic dysregulation; metabolic syndrome; treatment prediction;
   treatment response
ID LATE-LIFE DEPRESSION; DEHYDROEPIANDROSTERONE DHEA; HIPPOCAMPAL
   NEUROGENESIS; TREATMENT OUTCOMES; CHRONIC STRESS; ASSOCIATION;
   REMISSION; OBESITY; METAANALYSIS; CHOLESTEROL
AB Background Major depressive disorder (MDD) is associated with increased allostatic load (AL; a measure of physiological costs of repeated/chronic stress-responding) and metabolic dysregulation (MetD; a measure of metabolic health and precursor to many medical illnesses). Though AL and MetD are associated with poor somatic health outcomes, little is known regarding their relationship with antidepressant-treatment outcomes. Methods We determined pre-treatment AL and MetD in 67 healthy controls and 34 unmedicated, medically healthy MDD subjects. Following this, MDD subjects completed 8-weeks of open-label selective serotonin reuptake inhibitor (SSRI) antidepressant treatment and were categorized as 'Responders' (> 50% improvement in depression severity ratings) or 'Non-responders' (<50% improvement). Logistic and linear regressions were performed to determine if pre-treatment AL or MetD scores predicted SSRI-response. Secondary analyses examined cross-sectional differences between MDD and control groups. Results Pre-treatment AL and MetD scores significantly predicted continuous antidepressant response (i.e. absolute decreases in depression severity ratings) (p = 0.012 and 0.014, respectively), as well as post-treatment status as a Responder or Non-responder (p = 0.022 and 0.040, respectively), such that higher pre-treatment AL and MetD were associated with poorer SSRI-treatment outcomes. Pre-treatment AL and MetD of Responders were similar to Controls, while those of Non-responders were significantly higher than both Responders (p = 0.025 and 0.033, respectively) and Controls (p = 0.039 and 0.001, respectively). Conclusions These preliminary findings suggest that indices of metabolic and hypothalamic-pituitary-adrenal-axis dysregulation are associated with poorer SSRI-treatment response. To our knowledge, this is the first study to demonstrate that these markers of medical disease risk also predict poorer antidepressant outcomes.
C1 [Hough, Christina M.; Bersani, F. Saverio; Morford, Alexandra E.; Lindqvist, Daniel; Reus, Victor I.; Epel, Elissa S.; Wolkowitz, Owen M.] Univ Calif San Francisco, Sch Med, Dept Psychiat, UCSF Weill Inst Neurosci, San Francisco, CA 94143 USA.
   [Hough, Christina M.] Univ Calif Los Angeles, Dept Psychol, 405 Hilgard Ave, Los Angeles, CA 90024 USA.
   [Bersani, F. Saverio] Sapienza Univ Rome, Dept Human Neurosci, Rome, Italy.
   [Mellon, Synthia H.] Univ Calif San Francisco, Sch Med, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA USA.
   [Morford, Alexandra E.] Northwestern Univ, Feinberg Sch Med, Dept Psychiat & Behav Sci, Chicago, IL 60611 USA.
   [Lindqvist, Daniel] Lund Univ, Dept Clin Sci, Sect Psychiat, Lund, Sweden.
C3 University of California System; University of California San Francisco;
   University of California System; University of California Los Angeles;
   Sapienza University Rome; University of California System; University of
   California San Francisco; Northwestern University; Feinberg School of
   Medicine; Lund University
RP Hough, CM (corresponding author), Univ Calif San Francisco, Sch Med, Dept Psychiat, UCSF Weill Inst Neurosci, San Francisco, CA 94143 USA.; Hough, CM (corresponding author), Univ Calif Los Angeles, Dept Psychol, 405 Hilgard Ave, Los Angeles, CA 90024 USA.
EM cmhough@ucla.edu
RI Bersani, F./H-7234-2019; Epel, Elissa/ABI-6703-2022; Wolkowitz,
   Owen/J-6649-2013; reus, victor/I-7923-2015
OI Bersani, Francesco Saverio/0000-0002-7555-8020
FU National Institute of Mental Health (NIMH) [R01-MH083784]; O'Shaughnessy
   Foundation; UCSF Research Evaluation and Allocation Committee (REAC);
   National Institutes of Health/National Center for Research Resources
   (NIH/NCRR); NIH National Center for Advancing Translational Sciences
   (UCSF-CTSI Grant) [UL1 RR024131]; UCLA Graduate Division; National
   Science Foundation Graduate Research Fellowship Program (NSF)
   [DGE-1650604]; Swedish Research Council [2015-00387]; Marie Sklodowska
   Curie Actions [INCA 600398]; Swedish Society of Medicine; Sjobring
   Foundation; OM Persson Foundation; province of Scania (Sweden); UCSF
   Academic Senate; Soderstrom-Konigska Foundation
FX The authors gratefully acknowledge the assistance of Kevin Delucchi,
   PhD, Phuong Hoang, and Alanie Lazaro of UCSF, the Mendoza Lab of UC
   Davis, and the UCSF CTSI Clinical Research Center staff. This study was
   funded by the National Institute of Mental Health (NIMH) (Grant
   R01-MH083784), O'Shaughnessy Foundation, Tinberg family, UCSF Academic
   Senate, and UCSF Research Evaluation and Allocation Committee (REAC),
   and supported by National Institutes of Health/National Center for
   Research Resources (NIH/NCRR) and NIH National Center for Advancing
   Translational Sciences (UCSF-CTSI Grant UL1 RR024131). C.M.H. is
   supported by funding provided by UCLA Graduate Division and the National
   Science Foundation Graduate Research Fellowship Program (NSF Grant
   DGE-1650604). D.L. is supported by the Swedish Research Council
   (registration number 2015-00387), Marie Sklodowska Curie Actions, Cofund
   (Project INCA 600398), Swedish Society of Medicine, Soderstrom-Konigska
   Foundation, Sjobring Foundation, OM Persson Foundation and the province
   of Scania (Sweden) state grants (ALF). No granting or funding agency had
   a role in the study design and conduct; data collection, management,
   analysis and interpretation; or manuscript preparation, review, or
   approval. All authors had full access to all of the data in the study
   and take responsibility for the integrity of the data and the accuracy
   of the data analysis. The contents of this publication are solely the
   responsibility of the authors and do not necessarily represent the
   official views of the NIH.
CR Belleau EL, 2019, BIOL PSYCHIAT, V85, P443, DOI 10.1016/j.biopsych.2018.09.031
   Biessels GJ, 2015, NAT REV NEUROSCI, V16, P660, DOI 10.1038/nrn4019
   Bloch M, 1999, BIOL PSYCHIAT, V45, P1533, DOI 10.1016/S0006-3223(99)00066-9
   Bose M, 2009, CURR OPIN ENDOCRINOL, V16, P340, DOI 10.1097/MED.0b013e32832fa137
   Colle R, 2017, NEUROPSYCH DIS TREAT, V13, P9, DOI 10.2147/NDT.S121149
   Dranovsky A, 2006, BIOL PSYCHIAT, V59, P1136, DOI 10.1016/j.biopsych.2006.03.082
   First MB., 1997, Structured Clinical Interview for DSM-IV Axis I Disorders-Clinican Version (SCID-CV)
   Fischer S, 2017, NEUROSCI BIOBEHAV R, V83, P200, DOI 10.1016/j.neubiorev.2017.10.012
   Fitzsimons CP, 2009, MINI-REV MED CHEM, V9, P249, DOI 10.2174/138955709787316001
   Furtado M, 2015, PSYCHIAT RES, V229, P27, DOI 10.1016/j.psychres.2015.06.009
   Green E., 2017, Pers Med Psychiatry, V1-2, P65
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Hough CM, 2017, PSYCHONEUROENDOCRINO, V77, P122, DOI 10.1016/j.psyneuen.2016.11.035
   Jha MK, 2018, J AFFECT DISORDERS, V234, P34, DOI 10.1016/j.jad.2018.02.089
   Lecrubier Y, 2002, ACTA PSYCHIAT SCAND, V106, P7, DOI 10.1034/j.1600-0447.106.s415.2.x
   Liu CS, 2014, CNS NEUROL DISORD-DR, V13, P1693
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Makki Kassem, 2013, ISRN Inflamm, V2013, P139239, DOI 10.1155/2013/139239
   Maninger N, 2009, FRONT NEUROENDOCRIN, V30, P65, DOI 10.1016/j.yfrne.2008.11.002
   Marijnissen RM, 2017, PSYCHOL MED, V47, P1041, DOI 10.1017/S0033291716003196
   McEwen BS, 2003, BIOL PSYCHIAT, V54, P200, DOI 10.1016/S0006-3223(03)00177-X
   McEwen BS, 2001, ANN NY ACAD SCI, V933, P265, DOI 10.1111/j.1749-6632.2001.tb05830.x
   McEwen BS, 2000, BRAIN RES, V886, P172, DOI 10.1016/S0006-8993(00)02950-4
   McGregor G, 2015, MOL ENDOCRINOL, V29, P3, DOI 10.1210/me.2014-1328
   McMahon FJ, 2014, DIALOGUES CLIN NEURO, V16, P455
   Mojtabai R, 2017, DEPRESS ANXIETY, V34, P1123, DOI 10.1002/da.22677
   Mulvahill JS, 2017, J AM GERIATR SOC, V65, P2651, DOI 10.1111/jgs.15129
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Papakostas GI, 2003, NEUROPSYCHOBIOLOGY, V47, P146, DOI 10.1159/000070584
   Peixoto C, 2014, CURR DRUG TARGETS, V15, P901
   Preskorn S., 2009, OUTPATIENT MANAGEMEN, V3rd
   Rabkin JG, 2006, AM J PSYCHIAT, V163, P59, DOI 10.1176/appi.ajp.163.1.59
   Raison CL, 2006, TRENDS IMMUNOL, V27, P24, DOI 10.1016/j.it.2005.11.006
   Rush AJ, 2006, NEUROPSYCHOPHARMACOL, V31, P1841, DOI 10.1038/sj.npp.1301131
   Schmidt HD, 2007, BEHAV PHARMACOL, V18, P391, DOI 10.1097/FBP.0b013e3282ee2aa8
   Schmidt PJ, 2005, ARCH GEN PSYCHIAT, V62, P154, DOI 10.1001/archpsyc.62.2.154
   Seeman TE, 2001, P NATL ACAD SCI USA, V98, P4770, DOI 10.1073/pnas.081072698
   Sheline YI, 2019, BIOL PSYCHIAT, V85, P436, DOI 10.1016/j.biopsych.2019.01.011
   Soczynska JK, 2011, NEUROMOL MED, V13, P93, DOI 10.1007/s12017-010-8140-8
   Sonawalla SB, 2002, PSYCHOSOMATICS, V43, P310, DOI 10.1176/appi.psy.43.4.310
   Trivedi MH, 2006, AM J PSYCHIAT, V163, P28, DOI 10.1176/appi.ajp.163.1.28
   Van Doorn C, 2017, PHYSIOL BEHAV, V176, P207, DOI 10.1016/j.physbeh.2017.03.002
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Virtanen M, 2017, J CLIN PSYCHIAT, V78, pE1, DOI 10.4088/JCP.15m10399
   Vogelzangs N, 2014, NEUROPSYCHOPHARMACOL, V39, P1624, DOI 10.1038/npp.2014.9
   Vogelzangs N, 2011, J CLIN PSYCHIAT, V72, P598, DOI 10.4088/JCP.10m06559
   Walker ER, 2015, JAMA PSYCHIAT, V72, P334, DOI 10.1001/jamapsychiatry.2014.2502
   Wolkowitz OM, 1999, AM J PSYCHIAT, V156, P646
   Wolkowitz OM, 1997, BIOL PSYCHIAT, V41, P311, DOI 10.1016/S0006-3223(96)00043-1
   Wolkowitz Owen M, 2011, Dialogues Clin Neurosci, V13, P25
   Woo YS, 2016, J AFFECT DISORDERS, V203, P190, DOI 10.1016/j.jad.2016.06.018
NR 53
TC 14
Z9 15
U1 1
U2 11
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD SEP
PY 2021
VL 51
IS 12
BP 2117
EP 2125
AR PII S0033291720000896
DI 10.1017/S0033291720000896
PG 9
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA UL8PL
UT WOS:000692906900018
PM 32438932
DA 2025-06-11
ER

PT J
AU Poursafa, P
   Mansourian, M
   Motlagh, ME
   Ardalan, G
   Kelishadi, R
AF Poursafa, Parinaz
   Mansourian, Marjan
   Motlagh, Mohammad-Esmaeil
   Ardalan, Gelayol
   Kelishadi, Roya
TI Is air quality index associated with cardiometabolic risk factors in
   adolescents? The CASPIAN-III Study
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE Air pollutants; Cardiovascular risk factors; Adolescents; Prevention;
   Public health
ID CARDIOVASCULAR-DISEASE RISK; POLLUTION EXPOSURE; PARTICULATE MATTER;
   ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   MIDDLE-EAST; CHILDREN; INFLAMMATION; TEMPERATURE
AB Objective: This study aims to evaluate the association of air quality index (AQI) with cardiometabolic risk factors in a nationally representative sample of healthy adolescents.
   Methods: This nationwide survey was conducted among a stratified multi-stage probability sample of students, aged 10-18 years, from 27 provinces of Iran. Those students with history of any acute or chronic diseases, any medication use, as well as active or passive smoking were not included to the current study. Dietary and physical activity habits were documented by valid questionnaires. Physical examination and blood sampling were conducted under standard protocols. AQI data were obtained from air pollution monitoring sites from the entire country by considering air pollutants concentration, which includes all provincial counties containing different clusters.
   Results: The study participants consisted of 1413 students (48.8% boys) with a mean (SD) age of 14.81 +/- 2.48 years. The mean AQI level was 285.37 +/- 30.11 at national levels. After adjustment for confounding factors including age, sex, and anthropometric measures, as well as for dietary and physical activity habits, multiple linear regressions based on correlation of coefficients of the AI:T with cardiometabolic risk factors showed significant positive correlations of AQJ with systolic blood pressure, fasting blood glucose, total cholesterol, LDL-cholesterol, and triglycerides, as well as significant negative correlations with HDL-cholesterol. After adjustment for abovementioned confounding factors, binary logistic regressions analyses showed that AQI increased the risk of abnormal levels of some risk factors as elevated levels of systolic blood pressure, total cholesterol, and triglycerides.
   Conclusion: The associations of low air quality with some cardiometabolic factors in the current survey, although not strong, might be considered as an evidence of the adverse cardiometabolic consequences of exposure to air pollutants in the pediatric age group, and predisposing them to earlier development of noncommunicable diseases. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Poursafa, Parinaz] Isfahan Univ Med Sci, Environm Res Ctr, Dept Environm Engn, Esfahan, Iran.
   [Mansourian, Marjan] Isfahan Univ Med Sci, Fac Publ Hlth, Dept Biostat & Epidemiol, Esfahan, Iran.
   [Mansourian, Marjan; Ardalan, Gelayol; Kelishadi, Roya] Isfahan Univ Med Sci, Child Growth & Dev Res Ctr, Dept Pediat, Esfahan, Iran.
   [Motlagh, Mohammad-Esmaeil] Ahvaz jundishapur Univ Med Sci, Dept Pediat, Ahvaz, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Ahvaz Jundishapur
   University of Medical Sciences (AJUMS)
RP Kelishadi, R (corresponding author), Isfahan Univ Med Sci, Child Growth & Dev Res Ctr, Dept Pediat, Esfahan, Iran.
EM kelishadi@med.mui.ac.ir
RI Mansourian, Marjan/AAX-1011-2020; motlagh, Mohammad/AAC-2653-2019;
   Poursafa, Parinaz/U-2924-2017; Kelishadi, Roya/E-6154-2012
OI Mansourian, Marjan/0000-0002-7217-0282; motlagh, mohammad
   esmaiel/0000-0002-2971-8660; Poursafa, Parinaz/0000-0002-8067-4122;
   Kelishadi, Roya/0000-0001-7455-1495
CR Balagopal P, 2011, CIRCULATION, V123, P2749, DOI 10.1161/CIR.0b013e31821c7c64
   Brook Robert D., 2007, Reviews on Environmental Health, V22, P115
   Brook RD, 2008, J OCCUP ENVIRON MED, V50, P32, DOI 10.1097/JOM.0b013e31815dba70
   Brook RD, 2010, CURR ATHEROSCLER REP, V12, P291, DOI 10.1007/s11883-010-0122-7
   Calderón-Garcidueñas L, 2008, INHAL TOXICOL, V20, P499, DOI [10.1080/08958370701864797, 10.1080/08958370701864797 ]
   de Groot P, 2012, RADIOL CLIN N AM, V50, P863, DOI 10.1016/j.rcl.2012.06.006
   de Onis Mercedes, 2007, Bull World Health Organ, V85, P660, DOI 10.2471/BLT.07.043497
   Delavari A, 2009, DIABETES CARE, V32, P1092, DOI 10.2337/dc08-1800
   Di Cesare M, 2013, LANCET, V381, P585, DOI 10.1016/S0140-6736(12)61851-0
   Halonen JI, 2011, OCCUP ENVIRON MED, V68, P296, DOI 10.1136/oem.2010.056507
   Halonen JI, 2011, ENVIRON RES, V111, P281, DOI 10.1016/j.envres.2010.12.001
   Hashemi M, 2012, J RES MED SCI, V17, P317
   Hoek G, 2013, ENVIRON HEALTH-GLOB, V12, DOI 10.1186/1476-069X-12-43
   Hoffmann B, 2012, ENVIRON HEALTH PERSP, V120, P241, DOI 10.1289/ehp.1103647
   Iannuzzi A, 2010, CARDIOL YOUNG, V20, P186, DOI 10.1017/S1047951109992010
   Kelishadi R, 2008, J AM DIET ASSOC, V108, P82, DOI 10.1016/j.jada.2007.10.013
   Kelishadi R, 2007, B WORLD HEALTH ORGAN, V85, P19, DOI 10.2471/BLT.06.030783
   Kelishadi R, 2007, INT J CARDIOL, V117, P340, DOI 10.1016/j.ijcard.2006.06.012
   Kelishadi R, 2014, PAEDIATR INT CHILD H, V34, P165, DOI 10.1179/2046905513Y.0000000104
   Kelishadi R, 2013, ANN NUTR METAB, V62, P257, DOI 10.1159/000346489
   Kelishadi R, 2012, INT J PREVENTIVE MED, V3, P394
   Kelishadi R, 2011, J RES MED SCI, V16, P1234
   Kelishadi R, 2009, ATHEROSCLEROSIS, V203, P311, DOI 10.1016/j.atherosclerosis.2008.06.022
   Kent AL, 2012, J PAEDIATR CHILD H, V48, P730, DOI 10.1111/j.1440-1754.2012.02541.x
   Mendez R, 2013, AM J TRANSL RES, V5, P224
   Natl High Blood Pressure Educ Prog, 2004, PEDIATRICS, V114, P555
   O'Neill MS, 2011, ENVIRON HEALTH PERSP, V119, P844, DOI 10.1289/ehp.0901524
   Parnia S, 2014, RESP RES, V15, DOI 10.1186/1465-9921-15-22
   Pearson JF, 2010, DIABETES CARE, V33, P2196, DOI 10.2337/dc10-0698
   Poursafa Parinaz, 2011, Iran J Nurs Midwifery Res, V16, P257
   Rajagopalan S, 2012, DIABETES, V61, P3037, DOI 10.2337/db12-0190
   Román O, 2009, REV MED CHILE, V137, P1217, DOI [10.4067/S0034-98872009000900013, /S0034-98872009000900013]
   Sughis M, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-378
   Sun C, 2013, PEDIATR RES, V73, P523, DOI 10.1038/pr.2013.6
   Sun QH, 2005, JAMA-J AM MED ASSOC, V294, P3003, DOI 10.1001/jama.294.23.3003
   Sun ZC, 2013, SCI TOTAL ENVIRON, V448, P72, DOI 10.1016/j.scitotenv.2012.10.087
   Walker B, 2008, J NATL MED ASSOC, V100, P98, DOI 10.1016/S0027-9684(15)31182-2
   Xu XH, 2011, TOXICOL SCI, V124, P88, DOI 10.1093/toxsci/kfr211
   Xu ZB, 2011, PART FIBRE TOXICOL, V8, DOI 10.1186/1743-8977-8-20
   Yin F, 2013, ARTERIOSCL THROM VAS, V33, P1153, DOI 10.1161/ATVBAHA.112.300552
NR 40
TC 61
Z9 69
U1 1
U2 23
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
EI 1096-0953
J9 ENVIRON RES
JI Environ. Res.
PD OCT
PY 2014
VL 134
SI SI
BP 105
EP 109
DI 10.1016/j.envres.2014.07.010
PG 5
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA AX3CB
UT WOS:000346817100015
PM 25127520
DA 2025-06-11
ER

PT J
AU Wright, S
   Strunk, A
   Garg, A
AF Wright, Shari
   Strunk, Andrew
   Garg, Amit
TI New-onset depression among children, adolescents, and adults with
   hidradenitis suppurativa
SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
LA English
DT Article
DE comorbidity; depression; Explorys; hidradenitis suppurativa; incidence;
   mood disorder; new-onset
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; MAJOR DEPRESSION; PREVALENCE;
   DISEASE; ASSOCIATION; INSTRUMENTS; BURDEN
AB Background: Information on the risk of depression among children, adolescents, and adults with hidradenitis suppurativa (HS) is limited.
   Objective: To compare the risk of new-onset depression in patients with HS with that of control individuals.
   Methods: Retrospective cohort analysis of 49,280 adult and 3042 pediatric patients with HS and matched control individuals identified by using electronic health record data. The primary outcome was incident depression.
   Results: The crude incidence rate was 4.8 per 100 person-years in adult patients with HS compared to 3.0 per 100 person-years in control individuals. Among pediatric patients, the crude incidence rate was 4.2 per 100 person-years in patients with HS compared with 2.3 per 100 person-years in control individuals. In adjusted analysis, adults and pediatric patients with HS had a 10% (hazard ratio, 1.10; 95% confidence interval, 1.07-1.13; P<.001) and 26% (hazard ratio, 1.26; 95% confidence interval, 1.10-1.44; P<.001), respectively, increased risk of developing depression compared to control individuals. Among patients with HS, factors associated with depression included female sex, white race, smoking, and body mass index/obesity in adults and pediatric patients and substance abuse in adults only.
   Limitations: Patients not seeking care in health systems within the database were not captured.
   Conclusion: Children, adolescents, and adults with HS are at an increased risk for developing depression, independent of other common risk factors for depression.
C1 [Wright, Shari; Strunk, Andrew; Garg, Amit] Donald & Barbara Zucker Sch Med Hofstra Northwell, Dept Dermatol, New Hyde Pk, NY 11042 USA.
C3 Northwell Health
RP Garg, A (corresponding author), Donald & Barbara Zucker Sch Med Hofstra Northwell, 1991 Marcus Ave,Suite 300, New Hyde Pk, NY 11042 USA.
EM amgarg@northwell.edu
RI Garg, Amit/JEO-9043-2023
OI Garg, Amit/0000-0003-0886-6856
FU AbbVie
FX Supported in part by an education grant from AbbVie. AbbVie had no role
   in the design and conduct of the study; collection, management,
   analysis, and interpretation of the data; preparation, review, or
   approval of the manuscript; and decision to submit the manuscript for
   publication.
CR [Anonymous], 2016, LIB YOUR HEALTHC DAT
   Brody Debra J, 2018, NCHS Data Brief, P1
   Canoui-Poitrine F, 2009, J AM ACAD DERMATOL, V61, P51, DOI 10.1016/j.jaad.2009.02.013
   Ellervik C, 2014, NORD J PSYCHIAT, V68, P507, DOI 10.3109/08039488.2013.877074
   Farzanfar D, 2018, SKIN PHARMACOL PHYS, V31, P246, DOI 10.1159/000490002
   Fiest KM, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/s12888-014-0289-5
   Garg A, 2020, J AM ACAD DERMATOL, V82, P366, DOI 10.1016/j.jaad.2019.06.1301
   Garg A, 2018, J AM ACAD DERMATOL, V79, P495, DOI 10.1016/j.jaad.2018.02.053
   Garg A, 2016, JAMA DERMATOL, V152, P553, DOI 10.1001/jamadermatol.2015.4593
   Gold DA, 2014, J AM ACAD DERMATOL, V70, P699, DOI 10.1016/j.jaad.2013.11.014
   Gooderham M, 2015, J AM ACAD DERMATOL, V73, pS19, DOI 10.1016/j.jaad.2015.07.054
   Hoffman LK, 2017, SEMIN CUTAN MED SURG, V36, P86, DOI 10.12788/j.sder.2017.024
   Huilaja L, 2018, J INVEST DERMATOL, V138, P46, DOI 10.1016/j.jid.2017.06.020
   Ingram JR, 2018, BRIT J DERMATOL, V178, P917, DOI 10.1111/bjd.16101
   Jiménez-Gallo D, 2017, MEDIAT INFLAMM, V2017, DOI 10.1155/2017/2450401
   Kirby JS, 2017, JAMA DERMATOL, V153, P1263, DOI 10.1001/jamadermatol.2017.3596
   Mac Mahon J, 2020, PATIENT-RELAT OUTCOM, V11, P21, DOI 10.2147/PROM.S174299
   Matusiak L, 2017, J AM ACAD DERMATOL, V76, P670, DOI 10.1016/j.jaad.2016.10.042
   Matusiak L, 2009, ACTA DERM-VENEREOL, V89, P601, DOI 10.2340/00015555-0749
   McDonald CJ, 2003, CLIN CHEM, V49, P624, DOI 10.1373/49.4.624
   Miller IM, 2014, JAMA DERMATOL, V150, P1273, DOI 10.1001/jamadermatol.2014.1165
   Mitchell AJ, 2007, BRIT J GEN PRACT, V57, P144
   Nelson SJ, 2011, J AM MED INFORM ASSN, V18, P441, DOI 10.1136/amiajnl-2011-000116
   Olsen LR, 2004, ACTA PSYCHIAT SCAND, V109, P96, DOI 10.1046/j.0001-690X.2003.00231.x
   Onderdijk AJ, 2013, J EUR ACAD DERMATOL, V27, P473, DOI 10.1111/j.1468-3083.2012.04468.x
   Reddy S, 2019, JAMA DERMATOL, V155, P1284, DOI 10.1001/jamadermatol.2019.2610
   Revuz JE, 2008, J AM ACAD DERMATOL, V59, P596, DOI 10.1016/j.jaad.2008.06.020
   Richardson LP, 2010, PEDIATRICS, V125, pE1097, DOI 10.1542/peds.2009-2712
   Riis PT, 2019, BRIT J DERMATOL, V180, P774, DOI 10.1111/bjd.16998
   Sartorius K, 2009, BRIT J DERMATOL, V161, P831, DOI 10.1111/j.1365-2133.2009.09198.x
   Schrader AMR, 2014, J AM ACAD DERMATOL, V71, P460, DOI 10.1016/j.jaad.2014.04.001
   Shalom G, 2015, BRIT J DERMATOL, V173, P464, DOI 10.1111/bjd.13777
   Shavit E, 2015, J EUR ACAD DERMATOL, V29, P371, DOI 10.1111/jdv.12567
   Shlyankevich J, 2014, J AM ACAD DERMATOL, V71, P1144, DOI 10.1016/j.jaad.2014.09.012
   Strunk A, 2017, DERMATOLOGY, V233, P53, DOI 10.1159/000468148
   Thorlacius L, 2018, J INVEST DERMATOL, V138, P52, DOI 10.1016/j.jid.2017.09.008
   Tiri H, 2018, J AM ACAD DERMATOL, V79, P514, DOI 10.1016/j.jaad.2018.02.067
   Vazquez BG, 2013, J INVEST DERMATOL, V133, P97, DOI 10.1038/jid.2012.255
   Whooley MA, 1997, J GEN INTERN MED, V12, P439, DOI 10.1046/j.1525-1497.1997.00076.x
   Xu HX, 2017, POSTEP DERM ALERGOL, V34, P82, DOI 10.5114/ada.2017.65626
NR 40
TC 28
Z9 28
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0190-9622
EI 1097-6787
J9 J AM ACAD DERMATOL
JI J. Am. Acad. Dermatol.
PD NOV
PY 2020
VL 83
IS 5
BP 1360
EP 1366
DI 10.1016/j.jaad.2020.05.090
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA OH3XJ
UT WOS:000582505200043
PM 32446831
DA 2025-06-11
ER

PT J
AU Ferreira, YAM
   Kravchychyn, ACP
   Vicente, SDF
   Campos, RMD
   Tock, L
   Oyama, LM
   Boldarine, VT
   Masquio, DCL
   Thivel, D
   Shivappa, N
   Hébert, JR
   Dâmaso, AR
AF Martins Ferreira, Yasmin Alaby
   Pelissari Kravchychyn, Ana Claudia
   Ferreira Vicente, Sofia de Castro
   da Silveira Campos, Raquel Munhoz
   Tock, Lian
   Oyama, Lila Missae
   Boldarine, Valter Tadeu
   Landi Masquio, Deborah Cristina
   Thivel, David
   Shivappa, Nitin
   Hebert, James R.
   Damaso, Ana R.
TI An Interdisciplinary Weight Loss Program Improves Body Composition and
   Metabolic Profile in Adolescents With Obesity: Associations With the
   Dietary Inflammatory Index
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE inflammatory diet; cardiometabolic risk; interdisciplinary therapy;
   obesity; inflammation
ID LIFE-STYLE INTERVENTION; INSULIN-RESISTANCE; CARDIOMETABOLIC RISK; WAIST
   CIRCUMFERENCE; CARDIOVASCULAR RISK; NECK CIRCUMFERENCE; ADIPONECTIN;
   EXERCISE; LEPTIN; PATTERN
AB Background and Aims: The prevalence of overweight and obesity consitutes a global epidemic and it is growing around the world. Food and nutrition are essential requirements for promoting health and protecting against non-communicable chronic diseases, such as obesity and cardiovascular disease. Specific dietary components may modulate inflammation and oxidative stress in obese individuals. The Dietary Inflammatory Index (DII (R)) was developed to characterize the anti- and pro-inflammatory effects of individuals' diet. Few studies have investigated the role of diet-associated inflammation in adolescents with obesity. The present study aims to investigate the effects of an interdisciplinary weight loss therapy on DII scores and cardiometabolic risk in obese adolescents and possibles correlations.
   Methods: A total of 45 volunteers (14-19 years old) were recruited and enrolled for long-term interdisciplinary therapy including clinical, nutritional, psychological counseling, and exercise training. Adolescents had access to videos about health education weekly. Body composition and inflammatory and serum profiles were evaluated at baseline and after intervention. The food intake was obtained by 24-h food recall. Data was used to calculate energy-adjusted DII (E-DII) scores. Negative scores indicate an anti-inflammatory diet and positive scores indicates a pro-inflammatory diet. The sample was divided according to whether individuals increased or decreased E-DII scores after therapy.
   Results: After therapy the body mass index (BMI), body weight, body fat, abdominal, waist, neck, and hip circumferences decreased significantly. The mean of high-density lipoprotein cholesterol (HDL-c) increased after the therapy. There was found an improvement of inflammatory and cardiometabolic parameters. In exploratory analyses, this occurred mainly when the EDII improved.
   Conclusion: Long-term interdisciplinary therapy combined with a health education website improved inflammatory serum markers in obese adolescents. Reduction in DII scores was associated with reduction of cardiometabolic parameters, suggesting that an anti-inflammatory diet may be an effective strategy to prevent and treat obesity and related comorbidities.
C1 [Martins Ferreira, Yasmin Alaby; Pelissari Kravchychyn, Ana Claudia; Ferreira Vicente, Sofia de Castro; Oyama, Lila Missae; Damaso, Ana R.] Univ Fed Sao Paulo, Escoia Paulista Med, Post Grad Program Nutr, Sao Paulo, Brazil.
   [da Silveira Campos, Raquel Munhoz] Univ Fed Sao Carlos UFSCar, Therapeut Resources Lab, Dept Physiotherapy, Sao Carlos, SP, Brazil.
   [Tock, Lian] Univ Fed Sao Paulo, Post Grad Program Nutr, Sao Paulo, Brazil.
   [Oyama, Lila Missae; Boldarine, Valter Tadeu] Univ Fed Sao Paulo, Dept Physiol, Escola Paulista Med, Sao Paulo, Brazil.
   [Landi Masquio, Deborah Cristina] Ctr Univ Sao Camilo, Sao Paulo, Brazil.
   [Thivel, David] Clermont Auvergne Univ, EA 3533, Lab Metab Adaptat Exercise Physiol & Pathol Condi, Clermont Ferrand, France.
   [Thivel, David] CRNH Auvergne, Clermont Ferrand, France.
   [Shivappa, Nitin; Hebert, James R.] Univ South Carolina, Canc Prevent & Control Program, Columbia, SC 29208 USA.
   [Shivappa, Nitin; Hebert, James R.] Univ South Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA.
   [Shivappa, Nitin; Hebert, James R.] Connecting Hlth Innovat LLC CHI, Columbia, SC USA.
   [da Silveira Campos, Raquel Munhoz] Univ Fed Sao Paulo UNIFESP, Post Grad Program Interdisciplinary Hlth Sci, Santos, Brazil.
   [da Silveira Campos, Raquel Munhoz] Univ Fed Sao Paulo UNIFESP, Dept Biosci, Santos, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Sao
   Carlos; Universidade Federal de Sao Paulo (UNIFESP); Universidade
   Federal de Sao Paulo (UNIFESP); Centro Universitario Sao Camilo;
   Universite Clermont Auvergne (UCA); University of South Carolina System;
   University of South Carolina Columbia; University of South Carolina
   System; University of South Carolina Columbia; Connecting Health
   Innovations LLC; Universidade Federal de Sao Paulo (UNIFESP);
   Universidade Federal de Sao Paulo (UNIFESP)
RP Ferreira, YAM; Oyama, LM (corresponding author), Univ Fed Sao Paulo, Escoia Paulista Med, Post Grad Program Nutr, Sao Paulo, Brazil.; Oyama, LM (corresponding author), Univ Fed Sao Paulo, Dept Physiol, Escola Paulista Med, Sao Paulo, Brazil.
EM yasminalaby@hotmali.com; lmoyama@gmail.com
RI Shivappa, Nitin/X-2215-2018; Hebert, James/IUO-5628-2023; Oyama,
   Lila/B-7609-2012; Kravchychyn, Ana/B-2114-2018; Ferreira,
   Yasmin/ABC-4898-2020; Masquio, Deborah/GLQ-5953-2022; Dâmaso,
   Ana/AAT-6058-2021; Boldarine, Valter/AAC-9086-2020; Campos,
   Raquel/D-1994-2013
OI Campos, Raquel/0000-0001-6132-4349; Pelissari Kravchychyn, Ana
   Claudia/0000-0002-2919-2806
FU Foundation of Sao Paulo Research-FAPESP [2017/07372-1, 2015/143099];
   National Council for Scientific and Technological Development-CNPq
   [300654/2013-8, 409943/2016-9, 301322/2017-1]; Coordination of Higher
   Education Personnel Training-CAPES
FX This work was supported by: Foundation of Sao Paulo Research-FAPESP
   [2017/07372-1; 2015/143099], National Council for Scientific and
   Technological Development-CNPq [300654/2013-8 and 409943/2016-9;
   301322/2017-1], and Coordination of Higher Education Personnel
   Training-CAPES.
CR Ackel-D'Elia C, 2014, INT J SPORTS MED, V35, P164, DOI 10.1055/s-0033-1345128
   Almeida SS, 2017, J RENIN-ANGIO-ALDO S, V18, DOI 10.1177/1470320317703451
   Andrade PA, 2019, OBES SURG, V29, P457, DOI 10.1007/s11695-018-3530-3
   [Anonymous], 2015, DIABETES CARE, V38, pS67, DOI 10.2337/dc15-S013
   [Anonymous], 2000, A Report of the Subcommittee on Interpretation and Uses of Dietary Reference Intakes and the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes
   [Anonymous], 2000, WHO TECHN REP SER
   [Anonymous], 2009, Global health risks: mortality and burden of disease attributable to selected major risks
   Auerbach P, 2013, AM J PHYSIOL-REG I, V305, pR490, DOI 10.1152/ajpregu.00575.2012
   Bakker GCM, 2010, AM J CLIN NUTR, V91, P1044, DOI 10.3945/ajcn.2009.28822
   Blüher S, 2014, OBESITY, V22, P1701, DOI 10.1002/oby.20739
   Calder PC, 2011, BRIT J NUTR, V106, pS1, DOI 10.1017/S0007114511005460
   Carvalho CA, 2019, NUTRITION, V58, P187, DOI 10.1016/j.nut.2018.07.014
   Casas R., 2016, Immunome Res, V12, P1, DOI [DOI 10.4172/1745-7580.10000122, 10.4172/1745-7580.10000122]
   Chassaing B, 2017, CURR OPIN GASTROEN, V33, P417, DOI 10.1097/MOG.0000000000000401
   da Silva PL, 2012, RESP CARE, V57, P572, DOI 10.4187/respcare.01307
   Damaso AR, 2015, SABER EMAGRECER
   de Carvalho-Ferreira JP, 2015, PEPTIDES, V65, P20, DOI 10.1016/j.peptides.2014.11.010
   Silva DFD, 2016, CIENC SAUDE COLETIVA, V21, P1181, DOI 10.1590/1413-81232015214.08742015
   de Onis M, 2007, B WORLD HEALTH ORGAN, V85, P660, DOI 10.2471/BLT.07.043497
   Erro R, 2018, J NEUROL, V265, P12, DOI 10.1007/s00415-017-8639-0
   Frühbeck G, 2018, ADIPOCYTE, V7, P57, DOI 10.1080/21623945.2017.1402151
   Gajewska Joanna, 2011, Med Wieku Rozwoj, V15, P298
   Geraldo JM, 2008, ARQ BRAS ENDOCRINOL, V52, P951, DOI 10.1590/S0004-27302008000600006
   Harris HR, 2017, CANCER RES, V77, P1179, DOI 10.1158/0008-5472.CAN-16-2273
   Hebebrand J, 2017, OBESITY FACTS, V10, P284, DOI 10.1159/000479208
   Huang FY, 2014, ENDOCR J, V61, P921, DOI 10.1507/endocrj.EJ14-0157
   Instituto Brasileiro de Geografia e Estatistica, 2010, PESQ ORC FAM 2008 20
   Julian V, 2016, OBESITY FACTS, V9, P321, DOI 10.1159/000447456
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   Kurtoglu S, 2012, EUR J CLIN INVEST, V42, P623, DOI 10.1111/j.1365-2362.2011.02627.x
   Masquio DCL, 2015, NUTR HOSP, V31, P1540, DOI 10.3305/nh.2015.31.4.8442
   Lopera CA, 2016, PHYSIOL BEHAV, V165, P365, DOI 10.1016/j.physbeh.2016.08.019
   Lubkowska A, 2015, INT J ENV RES PUB HE, V12, P11528, DOI 10.3390/ijerph120911528
   Maffetone PB, 2017, FRONT PUBLIC HEALTH, V4, DOI 10.3389/fpubh.2016.00279
   Mahalle N, 2014, J DIABETES COMPLICAT, V28, P536, DOI 10.1016/j.jdiacomp.2012.09.008
   Mahbuba S, 2018, DIABETES METAB SYND, V12, P369, DOI 10.1016/j.dsx.2017.12.026
   Mameli C, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0181095
   Mansour Manal, 2016, Open Access Maced J Med Sci, V4, P118, DOI 10.3889/oamjms.2016.037
   Masquio DCL, 2015, BRIT J NUTR, V113, P1920, DOI 10.1017/S0007114515001129
   Masquio DCL, 2013, CLIN ENDOCRINOL, V79, P55, DOI 10.1111/j.1365-2265.2012.04504.x
   Matsudo S., 2012, Rev Bras Ativ Fis Saude Internet, V6, P5, DOI DOI 10.12820/RBAFS.V.6N2P5-18
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mazidi M, 2017, EUR J CLIN NUTR, V71, P1273, DOI 10.1038/ejcn.2017.133
   Mehra K, 2017, MED CLIN N AM, V101, P1151, DOI 10.1016/j.mcna.2017.06.004
   Mraz M, 2014, J ENDOCRINOL, V222, pR113, DOI 10.1530/JOE-14-0283
   Niclis C, 2018, NUTR CANCER, V70, P61, DOI 10.1080/01635581.2018.1397710
   Oh SW, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0188770
   Ouchi N, 2007, CLIN CHIM ACTA, V380, P24, DOI 10.1016/j.cca.2007.01.026
   Ozawa M, 2017, CLIN NUTR, V36, P506, DOI 10.1016/j.clnu.2016.01.013
   Patnaik L, 2017, INDIAN PEDIATR, V54, P377, DOI 10.1007/s13312-017-1110-6
   Pi-Sunyer X, 2009, POSTGRAD MED, V121, P21, DOI 10.3810/pgm.2009.11.2074
   Pinto AM, 2008, OBESITY, V16, P2456, DOI 10.1038/oby.2008.364
   Polyzos SA, 2016, DIABETOLOGIA, V59, P30, DOI 10.1007/s00125-015-3769-3
   Rajagopalan Archana, 2017, J Nat Sci Biol Med, V8, P144, DOI 10.4103/jnsbm.JNSBM_29_17
   Rajjo T, 2017, J CLIN ENDOCR METAB, V102, P763, DOI 10.1210/jc.2016-2574
   Reilly SM, 2017, NAT REV ENDOCRINOL, V13, P633, DOI 10.1038/nrendo.2017.90
   Rocha NP, 2017, J PEDIAT-BRAZIL, V93, P214, DOI 10.1016/j.jped.2017.01.002
   Sanches PD, 2012, ARQ BRAS CARDIOL, V99, P892
   Schwartz MW, 2017, ENDOCR REV, V38, P267, DOI 10.1210/er.2017-00111
   Schwimmer JB, 2003, J PEDIATR-US, V143, P500, DOI 10.1067/S0022-3476(03)00325-1
   Selthofer-Relatic K, 2018, DIABETES VASC DIS RE, V15, P260, DOI 10.1177/1479164117752491
   Sen S, 2018, PEDIATR OBES, V13, P292, DOI 10.1111/ijpo.12221
   Shivappa N, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00400
   Shivappa N, 2017, BRIT J NUTR, V117, P1323, DOI 10.1017/S0007114517001131
   Shivappa N, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600707
   Shivappa N, 2017, ARCH IRAN MED, V20, P108, DOI 0172002/AIM.0010
   Shivappa N, 2016, BRIT J NUTR, V116, P1077, DOI 10.1017/S0007114516002853
   Shivappa N, 2014, PUBLIC HEALTH NUTR, V17, P1689, DOI 10.1017/S1368980013002115
   TANNER JM, 1976, ARCH DIS CHILD, V51, P170, DOI 10.1136/adc.51.3.170
   Vázquez-Salas RA, 2016, BRIT J NUTR, V116, P1945, DOI 10.1017/S0007114516003986
   Vega GL, 2013, J OBES, V2013, DOI 10.1155/2013/409679
   Welty FK, 2013, CURR CARDIOL REP, V15, DOI 10.1007/s11886-013-0400-4
   Xavier HT, 2013, ARQ BRAS CARDIOL, V101, P1, DOI 10.5935/abc.2013S010
NR 74
TC 22
Z9 23
U1 2
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JUN 3
PY 2019
VL 6
AR 77
DI 10.3389/fnut.2019.00077
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA IC1YT
UT WOS:000470756700001
PM 31214594
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ong, P
   Athanasiadis, A
   Mahrholdt, H
   Borgulya, G
   Sechtem, U
   Kaski, JC
AF Ong, Peter
   Athanasiadis, Anastasios
   Mahrholdt, Heiko
   Borgulya, Gabor
   Sechtem, Udo
   Kaski, Juan Carlos
TI Increased coronary vasoconstrictor response to acetylcholine in women
   with chest pain and normal coronary arteriograms (cardiac syndrome X)
SO CLINICAL RESEARCH IN CARDIOLOGY
LA English
DT Article
DE Cardiac syndrome X; Microvascular angina; Vasoconstriction;
   Acetylcholine
ID ENDOTHELIAL FUNCTION; ANGINA-PECTORIS; ARTERY-DISEASE;
   MYOCARDIAL-ISCHEMIA; SEGMENT DEPRESSION; EXERCISE; SPASM;
   PATHOPHYSIOLOGY; INHIBITION; HEART
AB Cardiac syndrome X (CSX) is characterized by exercise-induced angina, positive exercise stress-test responses and angiographically normal coronary arteries. The condition characteristically affects more women than men and is often associated with coronary microvascular dysfunction, i.e., abnormal vasodilatory responses. Recent clinical observations suggest that increased coronary vasoconstriction may have a pathogenic role in CSX. We therefore sought to assess the prevalence of increased epicardial and microvascular coronary vasoconstriction in women with CSX.
   Among 1,120 consecutive women with angina undergoing diagnostic coronary angiography 39 fulfilled criteria for CSX (mean age 63 +/- A 9 years) and were included in the study (27 also complained about rest angina). Five women without angina (mean age 64 +/- A 24 years) and normal coronary arteriograms served as controls. Patients and controls underwent intracoronary acetylcholine testing with a standardized protocol. Severe (a parts per thousand yen75 % diameter reduction) epicardial constriction developed in 12 CSX patients (31 %) with reproduction of their angina in 10. All 12 patients showed diffuse epicardial constriction affecting mainly the distal coronary segments. Twenty-two CSX patients (56 %) experienced their usual angina without epicardial constriction of which 21 had ischemic ECG shifts. The remaining five CSX patients (13 %) had no angina or constriction in response to acetylcholine. None of the control patients had angina or constriction during ACH testing.
   Increased epicardial as well as microvascular coronary constriction in response to acetylcholine are frequent findings in women with CSX. The results indicate that inappropriate coronary constriction is likely to contribute to the anginal symptoms of these patients. The ACH-test may be useful in the clinical setting to unmask this vasomotor disorder.
C1 [Ong, Peter; Athanasiadis, Anastasios; Mahrholdt, Heiko; Sechtem, Udo] Robert Bosch Krankenhaus, Dept Cardiol, D-70376 Stuttgart, Germany.
   [Borgulya, Gabor] St Georges Univ London, Clin Trials Unit, London, England.
   [Kaski, Juan Carlos] St Georges Univ London, Cardiovasc Sci Res Ctr, London, England.
C3 Bosch; Robert Bosch Krankenhaus; City St Georges, University of London;
   St Georges University London; City St Georges, University of London; St
   Georges University London
RP Ong, P (corresponding author), Robert Bosch Krankenhaus, Dept Cardiol, Auerbachstr 110, D-70376 Stuttgart, Germany.
EM Peter.Ong@rbk.de
RI Kaski, Juan Carlos/LKM-8031-2024; Sechtem, Udo/ADK-6380-2022
OI Borgulya, Gabor/0000-0001-6396-6126
CR AIZAWA T, 1989, AM J CARDIOL, V63, pJ75, DOI 10.1016/0002-9149(89)90210-5
   Austen W G, 1975, Circulation, V51, P5
   BODEN WE, 1981, AM J CARDIOL, V48, P193, DOI 10.1016/0002-9149(81)90591-9
   Bugiardini R, 2004, CIRCULATION, V109, P2518, DOI 10.1161/01.CIR.0000128208.22378.E3
   CANNON RO, 1988, AM J CARDIOL, V61, P1338, DOI 10.1016/0002-9149(88)91180-0
   Coma-Canella I, 2006, INT J CARDIOL, V107, P200, DOI 10.1016/j.ijcard.2005.03.008
   Crea F, 2004, HEART, V90, P457, DOI 10.1136/hrt.2003.020594
   EGASHIRA K, 1995, HYPERTENSION, V25, P201, DOI 10.1161/01.HYP.25.2.201
   ELTAMIMI H, 1994, CIRCULATION, V89, P45, DOI 10.1161/01.CIR.89.1.45
   Gross L, 1934, AM J PATHOL, V10, P7
   Halcox JPJ, 2002, J AM COLL CARDIOL, V40, P1232, DOI 10.1016/S0735-1097(02)02139-3
   Infusino Fabio, 2009, Clin Cardiol, V32, pE40, DOI 10.1002/clc.20502
   Kaski JC, 2004, CIRCULATION, V109, P568, DOI 10.1161/01.CIR.0000116601.58103.62
   KASKI JC, 1995, J AM COLL CARDIOL, V25, P807, DOI 10.1016/0735-1097(94)00507-M
   Kaski JC, 2002, CARDIOVASC RES, V53, P620, DOI 10.1016/S0008-6363(01)00460-6
   Lanza GA, 2007, HEART, V93, P159, DOI 10.1136/hrt.2005.067330
   Lanza GA, 1997, AM J CARDIOL, V79, P1
   LEVENE DL, 1976, JAMA-J AM MED ASSOC, V236, P1018, DOI 10.1001/jama.236.9.1018
   Lüscher TF, 2009, EUR HEART J, V30, P1590, DOI 10.1093/eurheartj/ehp151
   Mehta PK, 2011, JACC-CARDIOVASC IMAG, V4, P514, DOI 10.1016/j.jcmg.2011.03.007
   Mohri M, 1998, LANCET, V351, P1165, DOI 10.1016/S0140-6736(97)07329-7
   NIELSEN H, 1987, AM HEART J, V114, P192, DOI 10.1016/0002-8703(87)90334-6
   Ong P, 2008, J AM COLL CARDIOL, V52, P523, DOI 10.1016/j.jacc.2008.04.050
   Patel MR, 2010, NEW ENGL J MED, V362, P886, DOI 10.1056/NEJMoa0907272
   Pauly DF, 2011, AM HEART J, V162, P678, DOI 10.1016/j.ahj.2011.07.011
   Pizzi C, 2004, CIRCULATION, V109, P53, DOI 10.1161/01.CIR.0000100722.34034.E4
   Reriani M, 2010, CIRCULATION, V122, P958, DOI 10.1161/CIRCULATIONAHA.110.967406
   SACKNOFF DM, 1993, AM HEART J, V125, P242, DOI 10.1016/0002-8703(93)90084-M
   SPECCHIA G, 1979, CIRCULATION, V59, P948, DOI 10.1161/01.CIR.59.5.948
   Sueda S, 1998, J Cardiol, V32, P155
   Sun HT, 2002, J AM COLL CARDIOL, V39, P847, DOI 10.1016/S0735-1097(02)01690-X
   Thorin E, 2001, J CARDIOVASC PHARM, V38, P90, DOI 10.1097/00005344-200107000-00010
   TODA N, 1983, AM J PHYSIOL, V245, pH937, DOI 10.1152/ajpheart.1983.245.6.H937
   Vaccarino V, 2011, CARDIOVASC RES, V90, P9, DOI 10.1093/cvr/cvq394
   Vermeltfoort IAC, 2010, CLIN RES CARDIOL, V99, P475, DOI 10.1007/s00392-010-0159-1
   WATERS DD, 1983, CIRCULATION, V67, P310, DOI 10.1161/01.CIR.67.2.310
   Yasue H, 2008, J AM COLL CARDIOL, V51, P1742, DOI 10.1016/j.jacc.2007.12.049
   Yilmaz A, 2010, CIRCULATION, V122, pE570, DOI 10.1161/CIRCULATIONAHA.110.984823
NR 38
TC 38
Z9 38
U1 0
U2 5
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1861-0684
EI 1861-0692
J9 CLIN RES CARDIOL
JI Clin. Res. Cardiol.
PD AUG
PY 2012
VL 101
IS 8
BP 673
EP 681
DI 10.1007/s00392-012-0442-4
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 975CQ
UT WOS:000306484800010
PM 22407462
DA 2025-06-11
ER

PT J
AU Gunderson, EP
   Quesenberry, CP
   Ning, X
   Jacobs, DR
   Gross, M
   Goff, DC
   Pletcher, MJ
   Lewis, CE
AF Gunderson, Erica P.
   Quesenberry, Charles P., Jr.
   Ning, Xian
   Jacobs, David R., Jr.
   Gross, Myron
   Goff, David C.
   Pletcher, Mark J.
   Lewis, Cora E.
TI Lactation Duration and Midlife Atherosclerosis
SO OBSTETRICS AND GYNECOLOGY
LA English
DT Article
ID ARTERY RISK DEVELOPMENT; BLOOD-PRESSURE; HYPERTENSIVE DISORDERS;
   YOUNG-ADULTS; FOLLOW-UP; PREGNANCY; WOMEN; PREDICTION; MOTHERS; STRESS
AB OBJECTIVE: To evaluate lactation duration in relation to subsequent atherosclerosis in women during midlife.
   METHODS: The Coronary Artery Risk Development in Young Adults study is a multicenter prospective cohort that enrolled 2,787 women in 1985-1986 (ages 18-30 years, 52% black, 48% white), of whom 2,014 (72%) attended the 20-year follow-up examination in 2005-2006. We selected 846 women (46% black) without heart disease or diabetes at baseline who delivered one or more times after the baseline evaluation, had cardiometabolic risk factors measured at baseline, and had maximum common carotid intima-media thickness (mm) measured at the 20-year follow-up examination in 2005-2006. Lactation duration was summed across all postbaseline births for each woman and (n, women) categorized as: 0 to less than 1 month (n=262), 1 to less than 6 months (n=210), 6 to less than 10 months (n=169), and 10 months or greater (n=205). Multiple linear regression models estimated mean common carotid intima-media thickness (95% confidence interval) and mean differences among lactation duration groups compared with the 0 to less than 1-month group adjusted for prepregnancy obesity, cardiometabolic status, parity, and other risk factors.
   RESULTS: Lactation duration had a graded inverse association with common carotid intima-media thickness; mean differences between 10 months or greater compared with 0 to less than 1 month ranged from -0.062 mm for unadjusted models (P trend <.001) to -0.029 mm for models fully adjusted for prepregnancy body mass index (BMI) and cardiometabolic risk factors, parity, smoking, and sociodemographics (P trend=.010). Stepwise addition of potential mediators (BMI, systolic blood pressure at the 20-year follow-up examination) modestly attenuated the lactation and common carotid intima-media thickness association to -0.027 and -0.023 mm (P trend=.019 and .054).
   CONCLUSION: Shorter lactation duration is associated with subclinical atherosclerosis independent of prepregnancy cardiometabolic risk factors and traditional risk factors. The magnitude of differences in carotid artery intima-media thickness may represent greater vascular aging. Lactation may have long-term benefits that lower cardiovascular disease risk in women.
C1 Kaiser Permanente No Calif, Div Res, Oakland, CA 94612 USA.
   Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
   Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.
   Univ Colorado Denver, Colorado Sch Publ Hlth, Aurora, CO USA.
   Univ Alabama Birmingham, Div Prevent Med, Birmingham, AL USA.
C3 Kaiser Permanente; University of California System; University of
   California San Francisco; University of Minnesota System; University of
   Minnesota Twin Cities; Colorado School of Public Health; University of
   Colorado System; University of Colorado Anschutz Medical Campus;
   Children's Hospital Colorado; University of Alabama System; University
   of Alabama Birmingham
RP Gunderson, EP (corresponding author), Kaiser Permanente No Calif, Div Res, Cardiovasc & Metab Condit Sect, 2000 Broadway, Oakland, CA 94612 USA.
EM Erica.Gunderson@kp.org
RI Jacobs, David/G-5405-2011
OI Jacobs, David/0000-0002-7232-0543
FU National Heart, Lung and Blood Institute (NHLBI) [AG0005]; University of
   Alabama at Birmingham [HHSN268201300025C, HHSN268201300026C];
   Northwestern University [HHSN268201300027C]; University of Minnesota
   [HHSN268201300028C]; Kaiser Foundation Research Institute
   [HHSN268201300029C]; Johns Hopkins University School of Medicine
   [HHSN268200900041C]; Intramural Research Program of the National
   Institute on Aging (NIA); NIA; National Institute of Diabetes, Digestive
   and Kidney Diseases [K01 DK059944, R01 DK090047]
FX The Coronary Artery Risk Development in Young Adults (CARDIA) study is
   conducted and supported by the National Heart, Lung and Blood Institute
   (NHLBI) in collaboration with the University of Alabama at Birmingham
   (HHSN268201300025C and HHSN268201300026C), Northwestern University
   (HHSN268201300027C), University of Minnesota (HHSN268201300028C), Kaiser
   Foundation Research Institute (HHSN268201300029C), and Johns Hopkins
   University School of Medicine (HHSN268200900041C). CARDIA is also
   partially supported by the Intramural Research Program of the National
   Institute on Aging (NIA) and an intraagency agreement between NIA and
   NHLBI (AG0005). The analyses were supported by grants from K01 DK059944
   (Gunderson, Principal Investigator [PI]) and R01 DK090047 (Gunderson,
   PI) from the National Institute of Diabetes, Digestive and Kidney
   Diseases. This manuscript was reviewed by CARDIA for scientific content.
CR Anderssen N, 1996, AM J EPIDEMIOL, V143, P351, DOI 10.1093/oxfordjournals.aje.a008749
   [Anonymous], BREASTF US CHILDR BO
   Bartick MC, 2013, OBSTET GYNECOL, V122, P111, DOI 10.1097/AOG.0b013e318297a047
   Callaway LK, 2013, J HUM HYPERTENS, V27, P309, DOI 10.1038/jhh.2012.45
   Cutter G R, 1991, Control Clin Trials, V12, p1S, DOI 10.1016/0197-2456(91)90002-4
   Ebina S, 2012, INT J WOMENS HEALTH, V4, P333, DOI 10.2147/IJWH.S33379
   Go AS, 2014, CIRCULATION, V129, pE28, DOI 10.1161/01.cir.0000441139.02102.80
   Groenewegen KA, 2016, EUR J PREV CARDIOL, V23, P264, DOI 10.1177/2047487314566999
   Gunderson EP, 2007, DIABETES, V56, P2990, DOI 10.2337/db07-1024
   Gunderson EP, 2007, OBSTET GYNECOL, V109, P729, DOI 10.1097/01.AOG.0000252831.06695.03
   Gunderson EP, 2010, DIABETES, V59, P495, DOI 10.2337/db09-1197
   Hanley AJG, 2004, DIABETES, V53, P1773, DOI 10.2337/diabetes.53.7.1773
   Hanley AJG, 2003, DIABETES, V52, P463, DOI 10.2337/diabetes.52.2.463
   Heinrichs M, 2002, STRESS, V5, P195, DOI 10.1080/1025389021000010530
   Johnsen SH, 2007, STROKE, V38, P2873, DOI 10.1161/STROKEAHA.107.487264
   Lewis CE, 1996, AM J EPIDEMIOL, V144, P247, DOI 10.1093/oxfordjournals.aje.a008919
   Light KC, 2000, HEALTH PSYCHOL, V19, P560, DOI 10.1037/0278-6133.19.6.560
   Lupton SJ, 2013, AM J OBSTET GYNECOL, V208, DOI 10.1016/j.ajog.2013.02.014
   Matias SL, 2014, AM J CLIN NUTR, V99, P115, DOI 10.3945/ajcn.113.073049
   McClure CK, 2012, AM J OBSTET GYNECOL, V207, DOI 10.1016/j.ajog.2012.04.030
   Mezzacappa ES, 2001, PSYCHOPHYSIOLOGY, V38, P988, DOI 10.1111/1469-8986.3860988
   Natland ST, 2012, INT BREASTFEED J, V7, DOI 10.1186/1746-4358-7-8
   Oken E, 2013, AM J CLIN NUTR, V98, P1048, DOI 10.3945/ajcn.113.065300
   Polak JF, 2010, STROKE, V41, P9, DOI 10.1161/STROKEAHA.109.566596
   Schwarz EB, 2010, OBSTET GYNECOL, V115, P41, DOI 10.1097/AOG.0b013e3181c5512a
   Schwarz EB, 2009, OBSTET GYNECOL, V113, P974, DOI 10.1097/01.AOG.0000346884.67796.ca
   Stuart JJ, 2013, J WOMENS HEALTH, V22, P37, DOI 10.1089/jwh.2012.3740
   Stuebe AM, 2011, AM J EPIDEMIOL, V174, P1147, DOI 10.1093/aje/kwr227
   Stuebe AM, 2009, AM J OBSTET GYNECOL, V200, DOI 10.1016/j.ajog.2008.10.001
   Stuebe AM, 2005, JAMA-J AM MED ASSOC, V294, P2601, DOI 10.1001/jama.294.20.2601
   Tigas S, 2002, J CLIN ENDOCR METAB, V87, P302, DOI 10.1210/jc.87.1.302
   Tu MT, 2006, J NEUROENDOCRINOL, V18, P494, DOI 10.1111/j.1365-2826.2006.01441.x
NR 32
TC 48
Z9 53
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0029-7844
J9 OBSTET GYNECOL
JI Obstet. Gynecol.
PD AUG
PY 2015
VL 126
IS 2
BP 381
EP 390
DI 10.1097/AOG.0000000000000919
PG 10
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA CN2WY
UT WOS:000358284500008
PM 26241429
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Rohner, M
   Heiz, R
   Feldhaus, S
   Bornstein, SR
AF Rohner, Markus
   Heiz, Robert
   Feldhaus, Simon
   Bornstein, Stefan R.
TI Hepatic-Metabolite-Based Intermittent Fasting Enables a Sustained
   Reduction in Insulin Resistance in Type 2 Diabetes and Metabolic
   Syndrome
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE insulin resistance; diabetes remission; non-alcoholic fatty liver;
   weight loss resistance; epigenetics
ID HDL-CHOLESTEROL; ASSOCIATION; MELLITUS; PROFILE; TRIGLYCERIDES;
   PREVALENCE; GLUCOSE; HEALTH; ADULTS; RISK
AB Insulin resistance is the hallmark of Type 2 Diabetes and is still an unmet medical need. Insulin resistance lies at the crossroads of non-alcoholic fatty liver disease, obesity, weight loss and exercise resistance, heart disease, stroke, depression, and brain health. Insulin resistance is purely nutrition related, with a typical molecular disease food intake pattern. The insulin resistant state is accessible by TyG as the appropriate surrogate marker, which is found to lead the personalized molecular hepatic nutrition system for highly efficient insulin resistance remission. Treating insulin resistance with a molecular nutrition-centered approach shifts the treatment paradigm of Type 2 Diabetes from management to cure. This allows remission within five months, with a high efficiency rate of 85%. With molecular intermittent fasting a very efficient treatment for prediabetes and metabolic syndrome is possible, improving the non-alcoholic fatty liver disease (NAFL) state and enabling the body to lose weight in a sustainable manner.
C1 [Rohner, Markus] EGB EpiGeneticBalance AG, Rheinfelden, Switzerland.
   [Heiz, Robert] Zentrum Komplementarmed AG, Uster, Switzerland.
   [Feldhaus, Simon] Paramed AG, Haldenstr 1, Baar, Switzerland.
   [Bornstein, Stefan R.] Tech Univ Dresden, Dept Med, Fetscherstr 74, D-01307 Dresden, Germany.
C3 Technische Universitat Dresden
RP Bornstein, SR (corresponding author), Tech Univ Dresden, Dept Med, Fetscherstr 74, D-01307 Dresden, Germany.; Bornstein, SR (corresponding author), Tech Univ Dresden, Dev & Int Affairs, Fetscherstr 74, D-01307 Dresden, Germany.
EM stefan.bornstein@uniklinikum-dresden.de
CR Achilike I, 2015, INT J OBESITY, V39, P228, DOI 10.1038/ijo.2014.113
   Ades PA, 2015, J CARDIOPULM REHABIL, V35, P193, DOI 10.1097/HCR.0000000000000106
   Araújo J, 2019, METAB SYNDR RELAT D, V17, P46, DOI 10.1089/met.2018.0105
   Arpón A, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00496
   Arpón A, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-38980-2
   Azemati B, 2017, CURR DEV NUTR, V1, DOI 10.3945/cdn.116.000299
   Bacha F, 2021, JCI INSIGHT, V6, DOI 10.1172/jci.insight.146000
   Bagnati M, 2016, CELL DEATH DIS, V7, DOI 10.1038/cddis.2016.203
   Banks WA, 2018, INT J OBESITY, V42, P391, DOI 10.1038/ijo.2017.231
   Baskota A, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0132335
   Bedogni G, 2006, BMC GASTROENTEROL, V6, DOI 10.1186/1471-230X-6-33
   Breen C, 2014, NUTR DIABETES, V4, DOI 10.1038/nutd.2014.2
   Castro-Barquero S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030689
   Chávez-Reyes J, 2021, FRONT PUBLIC HEALTH, V9, DOI 10.3389/fpubh.2021.559595
   Chen SO, 2013, PROG THEOR EXP PHYS, V2013, DOI 10.1093/ptep/ptt032
   Çin NNA, 2020, J PEDIATR ENDOCR MET, V33, P777, DOI 10.1515/jpem-2019-0310
   Corona G, 2021, REV ENDOCR METAB DIS, V22, P275, DOI 10.1007/s11154-021-09630-8
   De Rosa V, 2015, SEMIN IMMUNOL, V27, P300, DOI 10.1016/j.smim.2015.10.001
   Dong YT, 2019, EUR J CLIN NUTR, V73, P1172, DOI 10.1038/s41430-018-0372-y
   Eckel N, 2018, LANCET DIABETES ENDO, V6, P714, DOI 10.1016/S2213-8587(18)30137-2
   Farell A., 2019, AASLD
   Ferrannini E., 2009, CANAD J DIABETES, V33, P208
   Ford AH, 2015, AM J GERIAT PSYCHIAT, V23, P872, DOI 10.1016/j.jagp.2014.10.010
   Fryk E, 2021, EBIOMEDICINE, V65, DOI 10.1016/j.ebiom.2021.103264
   Gao X, 2017, NUTRITION, V33, P28, DOI 10.1016/j.nut.2016.08.005
   Gardner JP, 2005, CIRCULATION, V111, P2171, DOI 10.1161/01.CIR.0000163550.70487.0B
   Geraets AFJ, 2020, DIABETOLOGIA, V63, P2315, DOI 10.1007/s00125-020-05247-9
   Grubelnik V, 2020, LIFE-BASEL, V10, DOI 10.3390/life10120348
   Hall E, 2014, BMC MED, V12, DOI 10.1186/1741-7015-12-103
   Halldin AK, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2019-036709
   Hannon BA, 2019, CURR DEV NUTR, V3, DOI 10.1093/cdn/nzy094
   Hydes TJ, 2020, CLIN MOL HEPATOL, V26, P383, DOI 10.3350/cmh.2020.0067
   Imamura F, 2020, PLOS MED, V17, DOI 10.1371/journal.pmed.1003102
   Irvin MR, 2014, CIRCULATION, V130, P565, DOI 10.1161/CIRCULATIONAHA.114.009158
   Jakubowicz D, 2019, DIABETES CARE, V42, P2171, DOI 10.2337/dc19-1142
   Jensen AV, 2017, CLIN INFECT DIS, V65, P2091, DOI 10.1093/cid/cix703
   Jimenez-Rivera C, 2017, BMC PEDIATR, V17, DOI 10.1186/s12887-017-0867-z
   Joo HJ, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17093322
   Kaiser A, 2012, DIABETIC MED, V29, P190, DOI 10.1111/j.1464-5491.2011.03422.x
   Kelly J, 2020, AM J LIFESTYLE MED, V14, P406, DOI 10.1177/1559827620930962
   Kerr D., 2000, J DIABETES NURSING, V4, P108
   Khan RS, 2019, HEPATOLOGY, V70, P711, DOI 10.1002/hep.30429
   Kitae A, 2019, CAN J GASTROENTEROL, V2019, DOI 10.1155/2019/5121574
   Kolb H, 2020, BMC MED, V18, DOI 10.1186/s12916-020-01688-6
   Kron V, 2021, MEDICINA-LITHUANIA, V57, DOI 10.3390/medicina57030249
   Lai CQ, 2020, AM J CLIN NUTR, V112, P1200, DOI 10.1093/ajcn/nqaa233
   Lee JW, 2021, J AFFECT DISORDERS, V278, P259, DOI 10.1016/j.jad.2020.09.073
   Lee J, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-82053-2
   Lee Y, 2020, J AM HEART ASSOC, V9, DOI 10.1161/JAHA.119.014119
   Li XL, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-01403-7
   Lim EL, 2011, DIABETOLOGIA, V54, P2506, DOI 10.1007/s00125-011-2204-7
   Lim TK, 2020, DIABETES RES CLIN PR, V163, DOI 10.1016/j.diabres.2020.108150
   Luukkonen PK, 2018, DIABETES CARE, V41, P1732, DOI 10.2337/dc18-0071
   Lyu K, 2020, CELL METAB, V32, P654, DOI 10.1016/j.cmet.2020.08.001
   Ma ML, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-01303-w
   Madsen KS., 2019, COCHRANE DB SYST REV, P1
   Mamtani M, 2016, CLIN EPIGENETICS, V8, DOI 10.1186/s13148-016-0173-x
   Maples JM, 2015, AM J PHYSIOL-ENDOC M, V309, pE345, DOI 10.1152/ajpendo.00505.2014
   Masson W, 2016, ENDOCRINOL NUTR, V63, P327, DOI 10.1016/j.endonu.2016.04.004
   McGovern AP, 2021, DIABETOLOGIA, V64, P1184, DOI 10.1007/s00125-021-05404-8
   McKay J, 2020, BMC NUTR, V6, DOI 10.1186/s40795-020-00336-9
   Mongraw-Chaffin M, 2018, J AM COLL CARDIOL, V71, P1857, DOI 10.1016/j.jacc.2018.02.055
   Nägga K, 2018, NEUROLOGY, V90, pE73, DOI 10.1212/WNL.0000000000004749
   Nannini DR, 2019, CLIN EPIGENETICS, V11, DOI 10.1186/s13148-019-0767-1
   Owei I, 2017, BMJ OPEN DIAB RES CA, V5, DOI 10.1136/bmjdrc-2017-000415
   Pietiläinen KH, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000218
   Pugnaloni S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041112
   Rasmussen BB, 2002, J CLIN INVEST, V110, P1687, DOI 10.1172/JCI200215715
   Ren HH, 2020, CARDIOVASC DIABETOL, V19, DOI 10.1186/s12933-020-01035-2
   Rohner M., European Patent, Patent No. [EP1962826B1, 1962826]
   Rohner M., European Patent, Patent No. [EP3166639B1, 3166639]
   Rojas-Humpire R., 2021, J NUTR METAB, V6633700, P1
   Rundek T, 2010, ARCH NEUROL-CHICAGO, V67, P1195, DOI 10.1001/archneurol.2010.235
   Shimoda M., 2017, J DIABETES RES, V5856475, P1
   Si YQ, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000025025
   Simental-Mendia Luis E., 2008, Metabolic Syndrome and Related Disorders, V6, P299, DOI 10.1089/met.2008.0034
   Sung H, 2019, LANCET PUBLIC HEALTH, V4, pE137, DOI 10.1016/S2468-2667(18)30267-6
   Telles Shirley, 2018, BMC Res Notes, V11, P383, DOI 10.1186/s13104-018-3485-4
   Tiedemann LJ, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms16052
   Toth PP, 2019, MAYO CLIN PROC, V94, P1670, DOI 10.1016/j.mayocp.2019.03.028
   Vistisen D, 2014, PLOS MED, V11, DOI 10.1371/journal.pmed.1001602
   Wadolowska L, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071563
   Willi SM, 2004, DIABETES CARE, V27, P348, DOI 10.2337/diacare.27.2.348
   Wu SH, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/4094876
   Xin YQ, 2020, DIABETOLOGIA, V63, P2112, DOI 10.1007/s00125-020-05224-2
   Ye XF, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0851-z
   Zafar H, 2021, GUT MICROBES, V13, DOI 10.1080/19490976.2020.1848158
NR 87
TC 6
Z9 6
U1 0
U2 24
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD AUG
PY 2021
VL 53
IS 08
BP 529
EP 540
DI 10.1055/a-1510-8896
EA JUN 2021
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA TZ2ZL
UT WOS:000668312800001
PM 34192792
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Auryan, S
   Itamar, R
AF Auryan, Szalat
   Itamar, Raz
TI Gender-specific care of diabetes mellitus: particular considerations in
   the management of diabetic women
SO DIABETES OBESITY & METABOLISM
LA English
DT Review
DE cardiovascular risk factors; contraception; depression; diabetes
   mellitus; endothelial dysfunction; gestational diabetes mellitus;
   hormone replacement therapy; inflammation; macrovascular complications;
   metabolic syndrome; microvascular complications; osteoporosis;
   polycystic ovary syndrome; sex hormones; sex hormone receptors
ID CORONARY-HEART-DISEASE; POLYCYSTIC-OVARY-SYNDROME; POSTMENOPAUSAL
   HORMONE-THERAPY; IMPAIRED FASTING GLUCOSE; BONE-MINERAL DENSITY;
   ESTROGEN PLUS PROGESTIN; ENDOGENOUS SEX-HORMONES; C-REACTIVE PROTEIN;
   METABOLIC SYNDROME; RISK-FACTORS
AB In the past 30 years, the all-cause mortality and cardiovascular mortality rates for women with diabetes mellitus (DM), in contrast to men, have not declined. Furthermore, the difference between all-cause mortality rates in women with DM and those without DM has more than doubled. This urgently needs addressing. This review will analyse published medical literature relating to the specific management of DM in women and try to identify areas where gender affects care. We have identified specific gender differences in the pathophysiology of glucose homeostasis disorder, diabetes-related complications and any female gender-specific features of women with diabetes, such as contraception and the menopause. These gender-specific features of DM may offer a route to improved care for women and new therapeutic possibilities.
C1 [Auryan, Szalat] Hadassah Hebrew Univ Hosp, Dept Endocrinol & Metab, IL-91120 Jerusalem, Israel.
   [Itamar, Raz] Hadassah Hebrew Univ Hosp, Diabet Unit, IL-91120 Jerusalem, Israel.
C3 Hebrew University of Jerusalem; Hadassah University Medical Center;
   Hadassah University Hospital; Hebrew University of Jerusalem; Hadassah
   University Medical Center; Hadassah University Hospital
RP Auryan, S (corresponding author), Hadassah Hebrew Univ Hosp, Dept Endocrinol & Metab, IL-91120 Jerusalem, Israel.
EM auryans@hadassah.org.il
RI szalat, auryan/JNR-7010-2023
CR Abbott JD, 2007, AM J CARDIOL, V99, P626, DOI 10.1016/j.amjcard.2006.09.109
   Ahmed LA, 2006, OSTEOPOROSIS INT, V17, P495, DOI 10.1007/s00198-005-0013-x
   Ahmed ML, 1998, DIABETES CARE, V21, P831, DOI 10.2337/diacare.21.5.831
   Ahmed ML, 2001, J CLIN ENDOCR METAB, V86, P1188, DOI 10.1210/jc.86.3.1188
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Alexander CM, 2003, DIABETES, V52, P1210, DOI 10.2337/diabetes.52.5.1210
   American Diabetes Association, 2003, Diabetes Care, V26 Suppl 1, pS103
   Anderson GL, 2004, JAMA-J AM MED ASSOC, V291, P1701, DOI 10.1001/jama.291.14.1701
   Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   [Anonymous], COCHRANE DATABASE SY
   Arboix A, 2006, EUR NEUROL, V56, P6, DOI 10.1159/000094249
   ARSLANIAN SA, 1991, J CLIN ENDOCR METAB, V72, P920, DOI 10.1210/jcem-72-4-920
   Azziz R, 2006, J CLIN ENDOCR METAB, V91, P4237, DOI 10.1210/jc.2006-0178
   Balk EM, 2003, ANN INTERN MED, V139, P670, DOI 10.7326/0003-4819-139-8-200310210-00011
   Balkau B, 2002, DIABETES METAB, V28, P364
   Barrett-Connor E, 2004, ARCH INTERN MED, V164, P934, DOI 10.1001/archinte.164.9.934
   BARRETTCONNOR E, 1992, JAMA-J AM MED ASSOC, V268, P3333
   Barros RPA, 2006, TRENDS MOL MED, V12, P425, DOI 10.1016/j.molmed.2006.07.004
   Berger JS, 2006, JAMA-J AM MED ASSOC, V295, P306, DOI 10.1001/jama.295.3.306
   Bhasin S, 2007, LANCET, V369, P597, DOI 10.1016/S0140-6736(07)60280-3
   Bonds DE, 2006, J CLIN ENDOCR METAB, V91, P3404, DOI 10.1210/jc.2006-0614
   Booya F, 2005, BMC NEUROL, V5, DOI 10.1186/1471-2377-5-24
   Bryden KS, 1999, DIABETES CARE, V22, P1956, DOI 10.2337/diacare.22.12.1956
   Carnevale V, 2004, DIABETES-METAB RES, V20, P196, DOI 10.1002/dmrr.449
   Case AM, 1998, ARCH INTERN MED, V158, P1405, DOI 10.1001/archinte.158.13.1405
   Cavalot F, 2006, J CLIN ENDOCR METAB, V91, P813, DOI 10.1210/jc.2005-1005
   Champney KP, 2007, AM HEART J, V153, P970, DOI 10.1016/j.ahj.2007.03.036
   Chandra NC, 1998, ARCH INTERN MED, V158, P981, DOI 10.1001/archinte.158.9.981
   Chen HF, 2006, DIABETES CARE, V29, P2409, DOI 10.2337/dc06-1343
   Chmait Ramen, 2004, J Perinatol, V24, P617, DOI 10.1038/sj.jp.7211147
   Codner E, 2004, PEDIATR DIABETES, V5, P182, DOI 10.1111/j.1399-543X.2004.00059.x
   Codner E, 2007, J CLIN ENDOCR METAB, V92, P1209, DOI 10.1210/jc.2006-2641
   Collins R, 2003, LANCET, V361, P2005
   Cowie CC, 2006, DIABETES CARE, V29, P1263, DOI 10.2337/dc06-0062
   Dale KM, 2007, CURR MED RES OPIN, V23, P565, DOI 10.1185/030079906X167516
   Daneman D., 2002, Diabetes Spectrum, V15, P83, DOI 10.2337/diaspect.15.2.83
   Deedwania P, 2006, LANCET, V368, P919, DOI 10.1016/S0140-6736(06)69292-1
   Després JP, 2006, ANN MED, V38, P52, DOI 10.1080/07853890500383895
   Ding EL, 2006, JAMA-J AM MED ASSOC, V295, P1288, DOI 10.1001/jama.295.11.1288
   Dokras A, 2005, OBSTET GYNECOL, V106, P131, DOI 10.1097/01.AOG.0000167408.30893.6b
   Dorman JS, 2001, DIABETES, V50, P1857, DOI 10.2337/diabetes.50.8.1857
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Enzlin P, 2003, DIABETES CARE, V26, P409, DOI 10.2337/diacare.26.2.409
   Enzlin P, 2002, DIABETES CARE, V25, P672, DOI 10.2337/diacare.25.4.672
   Erol B, 2002, J SEX MARITAL THER, V28, P55, DOI 10.1080/00926230252851195
   *FDA, 2007, PIOGL ASS INCR INC F
   FDA, 2007, ROS RISK FRACT TYP 2
   Feig DS, 2002, LANCET, V359, P1690, DOI 10.1016/S0140-6736(02)08599-9
   Ferrara A, 2003, CIRCULATION, V107, P43, DOI 10.1161/01.CIR.0000042701.17528.95
   Ferreira I, 2007, J HYPERTENS, V25, P1009, DOI 10.1097/HJH.0b013e3280a94e76
   Fineberg SE, 2000, DRUG AGING, V17, P453, DOI 10.2165/00002512-200017060-00003
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   Forsbach-Sánchez G, 2005, ARCH MED RES, V36, P291, DOI 10.1016/j.arcmed.2005.03.001
   Forsén L, 1999, DIABETOLOGIA, V42, P920, DOI 10.1007/s001250051248
   Freire MBS, 1998, HYPERTENSION, V31, P896, DOI 10.1161/01.HYP.31.4.896
   Fuller JH, 2001, DIABETOLOGIA, V44, pS54, DOI 10.1007/PL00002940
   Gavin JR, 1997, DIABETES CARE, V20, P1183
   Genuth S, 2003, DIABETES CARE, V26, P3160
   *GLAXOSMITHKLEIN, 2007, CLIN TRIAL OBS INC I
   Glueck CJ, 2004, HUM REPROD, V19, P510, DOI 10.1093/humrep/deh109
   Gregg EW, 2007, ANN INTERN MED, V147, P149, DOI 10.7326/0003-4819-147-3-200708070-00167
   Grey M, 2002, J PSYCHOSOM RES, V53, P907, DOI 10.1016/S0022-3999(02)00312-4
   Grigoryan OR, 2006, GYNECOL ENDOCRINOL, V22, P198, DOI 10.1080/09513590600624317
   Gum PA, 2001, AM J CARDIOL, V88, P230, DOI 10.1016/S0002-9149(01)01631-9
   Hadjidakis DJ, 2006, J DIABETES COMPLICAT, V20, P302, DOI 10.1016/j.jdiacomp.2005.07.006
   Hanefeld M, 2003, DIABETES CARE, V26, P868, DOI 10.2337/diacare.26.3.868
   Hanson RL, 2002, DIABETES, V51, P3120, DOI 10.2337/diabetes.51.10.3120
   Harpaz D, 1998, AM J MED, V105, P494, DOI 10.1016/S0002-9343(98)00328-3
   Heap J, 2004, J PEDIATR-US, V144, P56, DOI 10.1016/j.jpeds.2003.10.066
   Hennekens CH, 2004, DIABETES CARE, V27, P2752, DOI 10.2337/diacare.27.11.2752
   Hjelm K, 2002, J ADV NURS, V40, P673, DOI 10.1046/j.1365-2648.2002.02427.x
   Hollander MH, 2007, OBSTET GYNECOL SURV, V62, P125, DOI 10.1097/01.ogx.0000253303.92229.59
   Howard BV, 2004, CIRCULATION, V110, P201, DOI 10.1161/01.CIR.0000134955.93951.D5
   Hu FB, 2001, ARCH INTERN MED, V161, P1717, DOI 10.1001/archinte.161.14.1717
   Hughes RCE, 2006, DIABETIC MED, V23, P318, DOI 10.1111/j.1464-5491.2006.01750.x
   Huxley R, 2006, BMJ-BRIT MED J, V332, P73, DOI 10.1136/bmj.38678.389583.7C
   *INT DIAB FED, 2003, DIAB ATL 2003 EX SUM
   Jacobs AK, 2002, J AM COLL CARDIOL, V39, P1608, DOI 10.1016/S0735-1097(02)01835-1
   Janghorbani M, 2006, DIABETES CARE, V29, P1573, DOI 10.2337/dc06-0440
   Jones MEE, 2001, J STEROID BIOCHEM, V79, P3, DOI 10.1016/S0960-0760(01)00136-4
   Jovanovic L, 2006, ENDOCRIN METAB CLIN, V35, P79, DOI 10.1016/j.ecl.2005.09.008
   Joyner J, 2002, HORM METAB RES, V34, P223, DOI 10.1055/s-2002-32144
   Juutilainen A, 2004, DIABETES CARE, V27, P2898, DOI 10.2337/diacare.27.12.2898
   Juutilainen A, 2007, DIABETES CARE, V30, P292, DOI 10.2337/dc06-1747
   Kanaya AM, 2003, ANN INTERN MED, V138, P1, DOI 10.7326/0003-4819-138-1-200301070-00005
   Kanaya AM, 2002, ARCH INTERN MED, V162, P1737, DOI 10.1001/archinte.162.15.1737
   Kastrati A, 2007, NEW ENGL J MED, V356, P1030, DOI 10.1056/NEJMoa067484
   Kawamoto R, 2007, J ATHEROSCLER THROMB, V14, P36, DOI 10.5551/jat.14.36
   Khoo Cheen Leen, 2005, J Br Menopause Soc, V11, P6
   Kim C, 2007, DIABETES CARE, V30, P1102, DOI 10.2337/dc06-2237
   Kip KE, 2004, CIRCULATION, V109, P706, DOI 10.1161/01.CIR.0000115514.44135.A8
   Kitzmiller JL, 1999, DIABETES CARE, V22, P874, DOI 10.2337/diacare.22.5.874
   Kjos SL, 1998, JAMA-J AM MED ASSOC, V280, P533, DOI 10.1001/jama.280.6.533
   Knopp Robert H, 2005, Curr Atheroscler Rep, V7, P472, DOI 10.1007/s11883-005-0065-6
   Korytkowski MT, 2005, METABOLISM, V54, P1626, DOI 10.1016/j.metabol.2005.06.011
   Kothari V, 2002, STROKE, V33, P1776, DOI 10.1161/01.STR.0000020091.07144.C7
   Kremer CI, 2004, AM J OBSTET GYNECOL, V190, P1438, DOI 10.1016/j.ajog.2004.02.032
   Kuch B, 2007, DIABETES CARE, V30, P946, DOI 10.2337/dc06-2123
   Kyvik KO, 2004, DIABETOLOGIA, V47, P377, DOI 10.1007/s00125-004-1331-9
   Langer O, 2006, ENDOCRIN METAB CLIN, V35, P53, DOI 10.1016/j.ecl.2005.09.007
   Langer O, 2005, AM J OBSTET GYNECOL, V192, P134, DOI 10.1016/j.ajog.2004.07.011
   Langer O, 2000, NEW ENGL J MED, V343, P1134, DOI 10.1056/NEJM200010193431601
   Langer O, 2007, OBSTET GYN CLIN N AM, V34, P255, DOI 10.1016/j.ogc.2007.03.004
   Le May C, 2006, P NATL ACAD SCI USA, V103, P9232, DOI 10.1073/pnas.0602956103
   Legato Marianne J, 2006, Gend Med, V3, P131, DOI 10.1016/S1550-8579(06)80202-0
   Léger J, 2006, J CLIN ENDOCR METAB, V91, P3947, DOI 10.1210/jc.2006-0711
   Leguizamón G, 2007, OBSTET GYN CLIN N AM, V34, P225, DOI 10.1016/j.ogc.2007.04.002
   Lin M, 2007, NEUROEPIDEMIOLOGY, V28, P46, DOI 10.1159/000097856
   Lloyd CE, 1996, ARTERIOSCL THROM VAS, V16, P720, DOI 10.1161/01.ATV.16.6.720
   Lorenzo C, 2003, DIABETES CARE, V26, P3153, DOI 10.2337/diacare.26.11.3153
   Loukovaara S, 2003, DIABETES CARE, V26, P1193, DOI 10.2337/diacare.26.4.1193
   Mansfield MW, 1996, ARTERIOSCL THROM VAS, V16, P160, DOI 10.1161/01.ATV.16.1.160
   Marra G, 2002, DIABETES CARE, V25, P370, DOI 10.2337/diacare.25.2.370
   Marroquin OC, 2004, CIRCULATION, V109, P714, DOI 10.1161/01.CIR.0000115517.26897.A7
   Mayes J S, 2004, Obes Rev, V5, P197, DOI 10.1111/j.1467-789X.2004.00152.x
   Meigs JB, 2002, DIABETES CARE, V25, P1845, DOI 10.2337/diacare.25.10.1845
   Meisinger C, 2002, ARCH INTERN MED, V162, P82, DOI 10.1001/archinte.162.1.82
   Merz C.N., 2006, J Am Coll Cardiol, V47, p21S
   Merz CNB, 2006, FERTIL STERIL, V85, P1425, DOI 10.1016/j.fertnstert.2005.01.009
   Mora S, 2006, JAMA-J AM MED ASSOC, V295, P1412, DOI 10.1001/jama.295.12.1412
   Mulnier HE, 2006, DIABETOLOGIA, V49, P2859, DOI 10.1007/s00125-006-0493-z
   Natarajan S, 2005, ARCH INTERN MED, V165, P430, DOI 10.1001/archinte.165.4.430
   Nathan DM, 2001, DIABETES CARE, V24, P1711
   Newton KM, 2003, DIABETES CARE, V26, P2810, DOI 10.2337/diacare.26.10.2810
   Nicodemus KK, 2001, DIABETES CARE, V24, P1192, DOI 10.2337/diacare.24.7.1192
   Oh JY, 2002, DIABETES CARE, V25, P55, DOI 10.2337/diacare.25.1.55
   Otsuki M, 2007, MENOPAUSE, V14, P404, DOI 10.1097/01.gme.0000247014.56254.12
   Ovalle F, 2002, FERTIL STERIL, V77, P1095, DOI 10.1016/S0015-0282(02)03111-4
   Pedersen SB, 2004, J CLIN ENDOCR METAB, V89, P1869, DOI 10.1210/jc.2003-031327
   Pettersson-Fernholm K, 2006, KIDNEY INT, V69, P1880, DOI 10.1038/sj.ki.5000348
   Pomerleau J, 1999, DIABETES CARE, V22, P430, DOI 10.2337/diacare.22.3.430
   Pouwer F, 2001, DIABETIC MED, V18, P595, DOI 10.1046/j.1464-5491.2001.00499.x
   Prasad K, 2006, CARDIOVASC DRUG REV, V24, P33, DOI 10.1111/j.1527-3466.2006.00033.x
   Rana JS, 2007, DIABETES CARE, V30, P53, DOI 10.2337/dc06-1456
   Rathmann W, 2003, DIABETOLOGIA, V46, P182, DOI 10.1007/s00125-002-1025-0
   Ray JG, 2001, QJM-INT J MED, V94, P435, DOI 10.1093/qjmed/94.8.435
   Regitz-Zagrosek V, 2006, CLIN RES CARDIOL, V95, P136, DOI 10.1007/s00392-006-0351-5
   Ridker PM, 2005, NEW ENGL J MED, V352, P1293, DOI 10.1056/NEJMoa050613
   Ritchie SA, 2007, NUTR METAB CARDIOVAS, V17, P319, DOI 10.1016/j.numecd.2006.07.005
   Rosenfeld AG, 2006, AM J CRIT CARE, V15, P556, DOI 10.4037/ajcc2006.15.6.556
   Rossouw JE, 2006, ANN NY ACAD SCI, V1089, P444, DOI 10.1196/annals.1386.046
   Rossouw JE, 2002, JAMA-J AM MED ASSOC, V288, P321, DOI 10.1001/jama.288.3.321
   Roy MS, 2004, ARCH OPHTHALMOL-CHIC, V122, P546, DOI 10.1001/archopht.122.4.546
   Rutter MK, 2004, CIRCULATION, V110, P380, DOI 10.1161/01.CIR.0000136581.59584.0E
   Rydall AC, 1997, NEW ENGL J MED, V336, P1849, DOI 10.1056/NEJM199706263362601
   Salpeter SR, 2006, DIABETES OBES METAB, V8, P538, DOI 10.1111/j.1463-1326.2005.00545.x
   Schultz CJ, 1999, DIABETES CARE, V22, P495, DOI 10.2337/diacare.22.3.495
   Schwartz AV, 2006, J CLIN ENDOCR METAB, V91, P3349, DOI 10.1210/jc.2005-2226
   Schwartz AV, 2005, J BONE MINER RES, V20, P596, DOI 10.1359/JBMR.041219
   Schwartz AV, 2001, J CLIN ENDOCR METAB, V86, P32, DOI 10.1210/jc.86.1.32
   Seliger SL, 2001, CURR OPIN NEPHROL HY, V10, P219, DOI 10.1097/00041552-200103000-00010
   Shawe Jill, 2003, Treat Endocrinol, V2, P321, DOI 10.2165/00024677-200302050-00004
   Sheetz MJ, 2002, JAMA-J AM MED ASSOC, V288, P2579, DOI 10.1001/jama.288.20.2579
   Shu W, 2007, POSTGRAD MED J, V83, P240, DOI 10.1136/pgmj.2006.053140
   Singh C, 2007, OBSTET GYN CLIN N AM, V34, P275, DOI 10.1016/j.ogc.2007.03.003
   Statement P., 2007, Diabetes Care, V30, DOI [DOI 10.2337/DC07-S004, 10.2337/dc07-S004]
   Steinberg HO, 2000, CIRCULATION, V101, P2040, DOI 10.1161/01.CIR.101.17.2040
   Stellato RK, 2000, DIABETES CARE, V23, P490, DOI 10.2337/diacare.23.4.490
   Strotmeyer ES, 2005, ARCH INTERN MED, V165, P1612, DOI 10.1001/archinte.165.14.1612
   Strotmeyer ES, 2004, J BONE MINER RES, V19, P1084, DOI 10.1359/JBMR.040311
   Strotmeyer ES, 2003, DIABETES CARE, V26, P1016, DOI 10.2337/diacare.26.4.1016
   Sundquist K, 2006, DIABETIC MED, V23, P1261, DOI 10.1111/j.1464-5491.2006.01959.x
   *TAK, 2007, OBS INC INC FRACT FE
   Takahashi K, 2007, INTERNAL MED, V46, P643, DOI 10.2169/internalmedicine.46.6094
   Tamer A, 2006, MED PRIN PRACT, V15, P190, DOI 10.1159/000092180
   Tavani A, 2002, J CLIN EPIDEMIOL, V55, P1082, DOI 10.1016/S0895-4356(02)00486-9
   Thorand B, 2007, DIABETES CARE, V30, P854, DOI 10.2337/dc06-1693
   Tuomilehto J, 2003, DIABETES CARE, V26, P61
   Tuominen JT, 1999, DIABETES CARE, V22, P1196, DOI 10.2337/diacare.22.7.1196
   Valerio G, 2002, HORM RES, V58, P266, DOI 10.1159/000066441
   Walsh JME, 2004, JAMA-J AM MED ASSOC, V291, P2243, DOI 10.1001/jama.291.18.2243
   Wang JJ, 2006, HEART, V92, P1583, DOI 10.1136/hrt.2006.090522
   Wexler DJ, 2005, DIABETES CARE, V28, P514, DOI 10.2337/diacare.28.3.514
   Whitsel EA, 2000, DIABETES CARE, V23, P241, DOI 10.2337/diacare.23.2.241
   Wong TY, 2002, JAMA-J AM MED ASSOC, V287, P1153, DOI 10.1001/jama.287.9.1153
   Xiang AH, 2006, DIABETES CARE, V29, P613, DOI 10.2337/diacare.29.03.06.dc05-1940
   Zendehdel K, 2003, JNCI-J NATL CANCER I, V95, P1797, DOI 10.1093/jnci/djg105
   Zhao W, 2006, PUBLIC HEALTH, V120, P696, DOI 10.1016/j.puhe.2006.04.012
NR 178
TC 58
Z9 67
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD DEC
PY 2008
VL 10
IS 12
BP 1135
EP 1156
DI 10.1111/j.1463-1326.2008.00896.x
PG 22
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 367BU
UT WOS:000260528300001
PM 18494812
DA 2025-06-11
ER

PT J
AU Gill, J
   Luckenbaugh, D
   Charney, D
   Vythilingam, M
AF Gill, Jessica
   Luckenbaugh, David
   Charney, Dennis
   Vythilingam, Meena
TI Sustained Elevation of Serum Interleukin-6 and Relative Insensitivity to
   Hydrocortisone Differentiates Posttraumatic Stress Disorder with and
   Without Depression
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Depression; glucocorticoid sensitivity; hydrocortisone; PTSD; serial
   sampling; serum IL-6
ID ENHANCED CORTISOL SUPPRESSION; CORONARY-ARTERY-DISEASE; PEPTIDASE-IV
   ACTIVITY; MAJOR DEPRESSION; DEXAMETHASONE-SUPPRESSION; ACTH RESPONSE;
   PSYCHOMETRIC PROPERTIES; MYOCARDIAL-INFARCTION; CYTOKINE PRODUCTION;
   METABOLIC SYNDROME
AB Background: Elevated levels of proinflammatory cytokines, especially interleukin-6 (IL-6), can mediate the greater risk for cardiovascular disease in individuals with posttraumatic stress disorder (PTSD), particularly in those with comorbid major depressive disorder (MDD). However, IL-6 levels are not consistently elevated in either PTSD or MDD. Although PTSD is associated with supersensitivity to glucocorticoids; prior studies have not evaluated the effect of comorbid MDD.
   Methods: Serum IL-6 levels were measured hourly between 7: 00 PM and 7: 00 AM in individuals with PTSD with comorbid MDD (PTSD + MDD) (n = 9) and compared with those with PTSD without MDD (PTSD - MDD) (n = 9) and nontraumatized healthy control subjects (n = 14). Group differences in serum IL-6, plasma adrenocorticotropic hormone (ACTH), and plasma cortisol response to 30 mg of intravenous hydrocortisone were evaluated using linear mixed models.
   Results: Only subjects with PTSD + MDD exhibited higher, overnight serum IL-6 levels compared with individuals with PTSD - MDD (p < .01) and healthy control subjects (p < .001). Peak overnight IL-6 levels positively correlated with severity of PTSD (r = .56, p < .01) and depressive symptoms (r = .54, p < .01). Hydrocortisone administration significantly reduced IL-6 levels in both PTSD groups; however, IL-6 levels in PTSD + MDD were higher than both PTSD - MDD (p < .05) and healthy control subjects (p < .01). Following hydrocortisone administration, there was a greater reduction in levels of ACTH in PTSD - MDD compared with control subjects (p < .01).
   Conclusions: Sustained elevations of overnight IL-6 levels and relatively decreased sensitivity to hydrocortisone distinguish PTSD + MDD from PTSD - MDD. Novel strategies that decrease IL-6 levels offer a new direction in the prevention and treatment of PTSD and associated comorbid medical illnesses.
C1 [Vythilingam, Meena] Off Assistant Secretary Def Hlth Affairs, Psychol Hlth Strateg Operat, Force Hlth Protect & Readiness, Falls Church, VA 22041 USA.
   [Gill, Jessica] NIMH, NINR, Bethesda, MD 20892 USA.
   [Luckenbaugh, David; Vythilingam, Meena] NIMH, Mood & Anxiety Disorders Program, Bethesda, MD 20892 USA.
   [Charney, Dennis] Mt Sinai Sch Med, New York, NY USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Nursing Research (NINR); NIH National Institute of Mental Health (NIMH);
   National Institutes of Health (NIH) - USA; NIH National Institute of
   Mental Health (NIMH); Icahn School of Medicine at Mount Sinai
RP Vythilingam, M (corresponding author), Off Assistant Secretary Def Hlth Affairs, Psychol Hlth Strateg Operat, Force Hlth Protect & Readiness, Skyline 4,Suite 800A,5113 Leesburg Pike, Falls Church, VA 22041 USA.
EM meena.vythilingam@ha.osd.mil
RI Gill, Gill/Q-2020-2017
FU National Institute of Mental Health Intramural Research Program
FX The research reported in this manuscript was undertaken at the National
   Institutes of Health and funded by the National Institute of Mental
   Health Intramural Research Program.
CR Aerni A, 2004, AM J PSYCHIAT, V161, P1488, DOI 10.1176/appi.ajp.161.8.1488
   Alesci S, 2005, J CLIN ENDOCR METAB, V90, P2522, DOI 10.1210/jc.2004-1667
   Andersen K, 2008, HORM METAB RES, V40, P635, DOI 10.1055/s-0028-1083810
   Angst MS, 2008, PAIN, V139, P15, DOI 10.1016/j.pain.2008.02.028
   Anisman H, 2009, J PSYCHIATR NEUROSCI, V34, P4
   [Anonymous], 1998, STRUCTURED CLIN INTE
   Baker DG, 2001, NEUROIMMUNOMODULAT, V9, P209, DOI 10.1159/000049028
   Beratis S, 2005, J PSYCHOSOM RES, V58, P15, DOI 10.1016/j.jpsychores.2004.03.010
   Bob P, 2010, J AFFECT DISORDERS, V120, P231, DOI 10.1016/j.jad.2009.03.017
   Boscarino JA, 2008, PSYCHOSOM MED, V70, P668, DOI 10.1097/PSY.0b013e31817bccaf
   Boscarino JA, 2006, COMPR PSYCHIAT, V47, P503, DOI 10.1016/j.comppsych.2006.02.006
   Capuron L, 2004, BRAIN BEHAV IMMUN, V18, P205, DOI 10.1016/j.bbi.2003.11.004
   Clum GA, 2000, J NERV MENT DIS, V188, P671, DOI 10.1097/00005053-200010000-00005
   Cole MA, 2000, PSYCHONEUROENDOCRINO, V25, P151, DOI 10.1016/S0306-4530(99)00045-1
   de Kloet CS, 2007, PSYCHONEUROENDOCRINO, V32, P215, DOI 10.1016/j.psyneuen.2006.12.009
   de Kloet C, 2008, PSYCHONEUROENDOCRINO, V33, P313, DOI 10.1016/j.psyneuen.2007.11.016
   Dominguez-Rodriguez A, 2004, CYTOKINE, V26, P89, DOI 10.1016/j.cyto.2004.01.003
   Elliott William J., 2001, American Journal of Hypertension, V14, p291S, DOI 10.1016/S0895-7061(01)02174-4
   Fries E, 2005, PSYCHONEUROENDOCRINO, V30, P1010, DOI 10.1016/j.psyneuen.2005.04.006
   Gill J, 2008, J TRAUMA STRESS, V21, P530, DOI 10.1002/jts.20372
   Goenjian AK, 1996, AM J PSYCHIAT, V153, P929
   Gokce N, 2002, CIRCULATION, V105, P1567, DOI 10.1161/01.CIR.0000012543.55874.47
   Golier JA, 2006, PSYCHONEUROENDOCRINO, V31, P1181, DOI 10.1016/j.psyneuen.2006.08.005
   Gray MJ, 2004, ASSESSMENT, V11, P330, DOI 10.1177/1073191104269954
   Griffin MG, 2005, AM J PSYCHIAT, V162, P1192, DOI 10.1176/appi.ajp.162.6.1192
   Harden LM, 2006, PHYSIOL BEHAV, V89, P146, DOI 10.1016/j.physbeh.2006.05.016
   Heppner PS, 2009, BMC MED, V7, DOI 10.1186/1741-7015-7-1
   Jacobs M, 2009, EUR J CLIN INVEST, V39, P437, DOI 10.1111/j.1365-2362.2009.02129.x
   Jakovljevic M, 2008, PSYCHIAT DANUB, V20, P406
   Janeway AC TP., 2005, Immunobiology: The immune system in health and disase
   Kanter ED, 2001, BIOL PSYCHIAT, V50, P238, DOI 10.1016/S0006-3223(01)01158-1
   Kibler JL, 2009, J TRAUMA DISSOCIATIO, V10, P135, DOI 10.1080/15299730802624577
   Kimerling Rachel, 2004, J Am Med Womens Assoc (1972), V59, P43
   Kop WJ, 2008, AM J CARDIOL, V101, P767, DOI 10.1016/j.amjcard.2007.11.006
   Kunz-Ebrecht SR, 2003, BRAIN BEHAV IMMUN, V17, P373, DOI 10.1016/S0889-1591(03)00029-1
   LICHTENBERGER E, 2003, ASSESSING ADOLESCENT
   Lindley SE, 2004, BIOL PSYCHIAT, V55, P940, DOI 10.1016/j.biopsych.2003.12.021
   Lipschitz DS, 2003, J AM ACAD CHILD PSY, V42, P1310, DOI 10.1097/01.chi.0000084832.67701.0d
   Maes M, 2001, MOL PSYCHIATR, V6, P475, DOI 10.1038/sj.mp.4000872
   Maes M, 2001, NEUROPSYCHOPHARMACOL, V24, P130, DOI 10.1016/S0893-133X(00)00168-8
   Maes M, 1999, BIOL PSYCHIAT, V45, P833, DOI 10.1016/S0006-3223(98)00131-0
   Marciniak MD, 2005, DEPRESS ANXIETY, V21, P178, DOI 10.1002/da.20074
   Miller RJ, 2001, CYTOKINE, V13, P253, DOI 10.1006/cyto.2000.0825
   Müller N, 2006, MOL PSYCHIATR, V11, P680, DOI 10.1038/sj.mp.4001805
   Oquendo MA, 2003, NEUROPSYCHOPHARMACOL, V28, P591, DOI 10.1038/sj.npp.1300050
   Otte C, 2005, NEUROPSYCHOPHARMACOL, V30, P1173, DOI 10.1038/sj.npp.1300676
   Pace TWW, 2009, PSYCHONEUROENDOCRINO, V34, P87, DOI 10.1016/j.psyneuen.2008.08.011
   Papanicolaou DA, 1998, ANN INTERN MED, V128, P127, DOI 10.7326/0003-4819-128-2-199801150-00009
   Pervanidou P, 2007, PSYCHONEUROENDOCRINO, V32, P991, DOI 10.1016/j.psyneuen.2007.07.001
   Pietrzak RH, 2010, HUM PSYCHOPHARM CLIN, V25, P335, DOI 10.1002/hup.1121
   Raison CL, 2003, AM J PSYCHIAT, V160, P1554, DOI 10.1176/appi.ajp.160.9.1554
   Rauch SAM, 2006, AM J GERIAT PSYCHIAT, V14, P316, DOI 10.1097/01.JGP.0000199382.96115.86
   Rohleder N, 2004, BIOL PSYCHIAT, V55, P745, DOI 10.1016/j.biopsych.2003.11.018
   Rush AJ, 1996, PSYCHOL MED, V26, P477, DOI 10.1017/S0033291700035558
   Sakic B, 2001, BRAIN BEHAV IMMUN, V15, P25, DOI 10.1006/brbi.1999.0576
   Sakic B, 1997, BRAIN RES BULL, V44, P155, DOI 10.1016/S0361-9230(97)00107-X
   Schelling G, 2006, ANN NY ACAD SCI, V1071, P46, DOI 10.1196/annals.1364.005
   Song YQ, 2008, PSYCHONEUROENDOCRINO, V33, P1155, DOI 10.1016/j.psyneuen.2008.05.005
   Ströhle A, 2008, J PSYCHIATR RES, V42, P1185, DOI 10.1016/j.jpsychires.2008.01.015
   Tanielian T., 2008, INVISIBLE WOUNDS MEN
   Tyring S, 2006, LANCET, V367, P29, DOI 10.1016/S0140-6736(05)67763-X
   Uddin M, 2010, P NATL ACAD SCI USA, V107, P9470, DOI 10.1073/pnas.0910794107
   Vgontzas AN, 2005, NEUROIMMUNOMODULAT, V12, P131, DOI 10.1159/000084844
   Vollmer-Conna U, 2004, PSYCHOL MED, V34, P1289, DOI 10.1017/S0033291704001953
   von Känel R, 2007, J PSYCHIATR RES, V41, P744, DOI 10.1016/j.jpsychires.2006.06.009
   von Känel R, 2010, NEUROIMMUNOMODULAT, V17, P39, DOI 10.1159/000243084
   Vythilingam M, 2002, AM J PSYCHIAT, V159, P2072, DOI 10.1176/appi.ajp.159.12.2072
   Vythilingam M, 2010, PSYCHONEUROENDOCRINO, V35, P442, DOI 10.1016/j.psyneuen.2009.08.006
   Wang HH, 2010, J PSYCHIATR RES, V44, P385, DOI 10.1016/j.jpsychires.2009.10.001
   Weis F, 2006, J THORAC CARDIOV SUR, V131, P277, DOI 10.1016/j.jtcvs.2005.07.063
   Wichers MC, 2007, J PSYCHOSOM RES, V62, P207, DOI 10.1016/j.jpsychores.2006.09.007
   WILLICH SN, 1992, AM J CARDIOL, V70, P65, DOI 10.1016/0002-9149(92)91391-G
   Woo P, 2005, ARTHRITIS RES THER, V7, pR1281, DOI 10.1186/ar1826
   Yehuda R, 2006, PSYCHONEUROENDOCRINO, V31, P447, DOI 10.1016/j.psyneuen.2005.10.007
   Yehuda R, 2004, AM J PSYCHIAT, V161, P1397, DOI 10.1176/appi.ajp.161.8.1397
   YEHUDA R, 1995, ARCH GEN PSYCHIAT, V52, P583
   ZALCMAN S, 1994, BRAIN RES, V643, P40, DOI 10.1016/0006-8993(94)90006-X
NR 77
TC 69
Z9 74
U1 0
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD DEC 1
PY 2010
VL 68
IS 11
BP 999
EP 1006
DI 10.1016/j.biopsych.2010.07.033
PG 8
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 688FG
UT WOS:000284834600007
PM 20951370
DA 2025-06-11
ER

PT J
AU Antunes, LD
   da Jornada, MN
   Ramalho, L
   Hidalgo, MPL
AF Antunes, Luciana da Conceicao
   da Jornada, Manoela Neves
   Ramalho, Leticia
   Loayza Hidalgo, Maria Paz
TI Correlation of shift work and waist circumference, body mass index,
   chronotype and depressive symptoms
SO ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA
LA English
DT Article
DE Shift work; sleep-wake cycle; waist circumference; depressive symptoms;
   chronotype
ID METABOLIC SYNDROME; SLEEP; GLUCOSE; LEPTIN; MOOD; RISK
AB Objective: Correlate shift work with body mass index (BMI), waist circumference, chronotype and depressive symptoms. Subjects and methods:This study comprising 14 shift workers and 13 day workers. Subjects were workers from the health area aged 25 to 60 years. Minor psychiatric disorders were accessed by Self Report Questionnaire (SRQ-20) and depressive symptoms by Beck Depression Inventory (BDI). Chronotype was accessed using Morningness-Eveningness Questionnaire (MEQ). Anthropometric measures were taken. Results: Shift workers presented higher BMI (P = 0.03) and waist circumference (P = 0.004) than day workers. Years on shift work were significantly correlated to waist circumference (r = 0.43; P = 0.03) and age (r = 0.47; P = 0.02). Shift work was not correlated with depressive symptoms and chronotype. Conclusion: These results may suggest a role played by shift work on the development and/or the early clinic manifestations of metabolic disturbances, becoming a risk factor to metabolic syndrome. Arq Bras Endocrinol Metab. 2010;54(7):652-6
C1 [Antunes, Luciana da Conceicao] Univ Fed Rio Grande do Sul, Fac Med, Sch Med, Postgraduat Program Med Sci, BR-90035003 Porto Alegre, RS, Brazil.
   [Loayza Hidalgo, Maria Paz] Univ Fed Rio Grande do Sul, Clin Hosp Porto Alegre HCPA, Human Chronobiol Program, Psychiat & Legal Med Dept,Med Sch, BR-90035003 Porto Alegre, RS, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Universidade Federal do Rio
   Grande do Sul
RP Antunes, LD (corresponding author), Univ Fed Rio Grande do Sul, Fac Med, Sch Med, Postgraduat Program Med Sci, Rua Ramiro Barcelos 2400,2 Andar, BR-90035003 Porto Alegre, RS, Brazil.
EM lc-antunes@hotmail.com
RI Antunes, Luciana/GQZ-3088-2022; C. Antunes, Luciana/F-1732-2015
OI C. Antunes, Luciana/0000-0002-0106-0721; Hidalgo, Maria
   Paz/0000-0002-7886-770X
FU Fundo de Incentivo a Pesquisa e Eventos (FIPE) at Hospital de Clinicas
   de Porto Alegre, Brazil
FX This work was supported by Fundo de Incentivo a Pesquisa e Eventos
   (FIPE) at Hospital de Clinicas de Porto Alegre, Brazil.
CR [Anonymous], JAMA
   Beersma DGM, 2007, PHYSIOL BEHAV, V90, P190, DOI 10.1016/j.physbeh.2006.09.010
   Biggi N, 2008, CHRONOBIOL INT, V25, P443, DOI 10.1080/07420520802114193
   Conway PM, 2008, APPL ERGON, V39, P630, DOI 10.1016/j.apergo.2008.01.007
   Copertaro A, 2008, MED LAV, V99, P444
   Di Lorenzo L, 2003, INT J OBESITY, V27, P1353, DOI 10.1038/sj.ijo.0802419
   Esquirol Y, 2009, CHRONOBIOL INT, V26, P544, DOI 10.1080/07420520902821176
   Garaulet M, 2009, CURR OPIN LIPIDOL, V20, P127, DOI 10.1097/MOL.0b013e3283292399
   Gorenstein C, 1999, J CLIN PSYCHOL, V55, P553, DOI 10.1002/(SICI)1097-4679(199905)55:5<553::AID-JCLP3>3.0.CO;2-D
   Hidalgo MP, 2009, PSYCHIAT CLIN NEUROS, V63, P283, DOI 10.1111/j.1440-1819.2009.01965.x
   Holmbäck U, 2003, EUR J NUTR, V42, P75, DOI 10.1007/s00394-003-0386-6
   Inyushkin AN, 2009, J NEUROENDOCRINOL, V21, P705, DOI 10.1111/j.1365-2826.2009.01889.x
   Lamont Elaine Waddington, 2007, Dialogues Clin Neurosci, V9, P333
   Lin YC, 2009, CHRONOBIOL INT, V26, P740, DOI 10.1080/07420520902929029
   Morgan L, 2003, CHRONOBIOL INT, V20, P795, DOI 10.1081/CBI-120024218
   Morikawa Y, 2005, SCAND J WORK ENV HEA, V31, P179, DOI 10.5271/sjweh.867
   Morikawa Y, 2008, J OCCUP HEALTH, V50, P270, DOI 10.1539/joh.L7116
   Morikawa Y, 2007, SCAND J WORK ENV HEA, V33, P45, DOI 10.5271/sjweh.1063
   Motivala SJ, 2009, PSYCHONEUROENDOCRINO, V34, P540, DOI 10.1016/j.psyneuen.2008.10.016
   Ptitsyn AA, 2007, BMC BIOINFORMATICS, V8, DOI 10.1186/1471-2105-8-395
   Roenneberg T, 2003, CURR BIOL, V13, pR198, DOI 10.1016/S0960-9822(03)00124-6
   ROMON M, 1993, AM J CLIN NUTR, V57, P476, DOI 10.1093/ajcn/57.4.476
   Scheer FAJL, 2009, P NATL ACAD SCI USA, V106, P4453, DOI 10.1073/pnas.0808180106
   Shea SA, 2005, J CLIN ENDOCR METAB, V90, P2537, DOI 10.1210/jc.2004-2232
   Sookoian S, 2007, J INTERN MED, V261, P285, DOI 10.1111/j.1365-2796.2007.01766.x
   Sookoian S, 2009, ATHEROSCLEROSIS, V207, P346, DOI 10.1016/j.atherosclerosis.2009.06.008
   Tanofsky-Kraff M, 2004, OBES RES, V12, P1361, DOI 10.1038/oby.2004.171
   Wolk R, 2007, EXP PHYSIOL, V92, P67, DOI 10.1113/expphysiol.2006.033787
   Woo JM, 2008, INT J DISABIL HUM DE, V7, P185
   Yamada Y, 2001, SCAND J WORK ENV HEA, V27, P318, DOI 10.5271/sjweh.620
   Yang ST, 2009, ENDOCRINOLOGY, V150, P2153, DOI 10.1210/en.2008-0705
NR 31
TC 33
Z9 36
U1 0
U2 9
PU SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA
PI RIO DE JANEIRO, RJ
PA RUA HUMAITA, 85 CJ 501, RIO DE JANEIRO, RJ, 22261-000, BRAZIL
SN 0004-2730
J9 ARQ BRAS ENDOCRINOL
JI Arq. Bras. Endocrinol. Metabol.
PD OCT
PY 2010
VL 54
IS 7
BP 652
EP 656
DI 10.1590/S0004-27302010000700010
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 677YL
UT WOS:000284032800010
PM 21085771
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ono, R
   Yamazaki, S
   Takegami, M
   Otani, K
   Sekiguchi, M
   Onishi, Y
   Hayashino, Y
   Kikuchi, S
   Konno, S
   Fukuhara, S
AF Ono, Rei
   Yamazaki, Shin
   Takegami, Misa
   Otani, Koji
   Sekiguchi, Miho
   Onishi, Yoshihiro
   Hayashino, Yasuaki
   Kikuchi, Shin-ichi
   Konno, Shin-ichi
   Fukuhara, Shunichi
TI Gender Difference in Association Between Low Back Pain and Metabolic
   Syndrome Locomotive Syndrome and Health Outcome in Aizu Cohort
   Study (LOHAS)
SO SPINE
LA English
DT Article
DE low back pain; metabolic syndrome; community-based subject; prevalence
ID GENERAL JAPANESE POPULATION; 3RD NATIONAL-HEALTH;
   CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY; BLOOD-PRESSURE; NECK PAIN;
   PREVALENCE; LIFE; MENOPAUSE; MORTALITY
AB Study Design. Cross-sectional survey.
   Objective. To investigate the relationship between low back pain (LBP) and metabolic syndrome (Mets) in community-based Japanese subjects.
   Summary of Background Data. Relatively few reports have demonstrated a relationship between general pain and Mets, and none have addressed the relationship between LBP and Mets.
   Methods. This study enrolled 2650 people from among residents aged 40 to 74 years in Tadami and Minamiaizu, Fukushima, Japan, who participated in health checkups conducted in 2008. LBP was defined as lower back pain continuing for more than 24 hours and severe enough to merit treatment, or it was based on clinical prediction rules from the clinical diagnosis support tool to identify patients with lumbar spinal stenosis. Mets was defined according to the Japanese criteria recommended by the Japanese Society of Internal Medicine. Prevalence of Mets was recorded for subjects with and without LBP. The relationship between LBP and Mets was investigated, using a generalized linear model. With LBP as the main explanatory variable and Mets as the outcome variable, risk ratios of Mets were calculated for men and women.
   Results. In this study, we analyzed a total of 1395 subjects. In men, the prevalence of Mets was 21.2% in those without LBP and 24.7% in those with LBP. In women, the prevalence of Mets was 12.4% in those without LBP and 23.7% in those with LBP. After adjusting for factors such as age, body mass index, occupational status, SF-36 mental health, and physical activity level, no relationship was noted between LBP and Mets in men. However, in women, the risk ratio for Mets in subjects with LBP compared with those without LBP was 1.5 (95% confidence interval, 1.0-2.1).
   Conclusion. We observed a tendency toward higher prevalence of Mets among those with LBP than among those without it in women, but not in men.
C1 [Ono, Rei] Kobe Univ, Grad Sch Hlth Sci, Dept Community Hlth Sci, Suma Ku, Kobe, Hyogo 6540142, Japan.
   [Ono, Rei; Yamazaki, Shin; Takegami, Misa; Hayashino, Yasuaki; Fukuhara, Shunichi] Kyoto Univ, Grad Sch Med & Publ Hlth, Dept Epidemiol & Hlth Care Res, Kyoto, Japan.
   [Yamazaki, Shin; Onishi, Yoshihiro; Fukuhara, Shunichi] Inst Hlth Outcomes & Proc Evaluat Res, Kyoto, Japan.
   [Otani, Koji; Sekiguchi, Miho; Kikuchi, Shin-ichi; Konno, Shin-ichi] Fukushima Med Univ, Sch Med, Dept Orthoped Surg, Fukushima, Japan.
   [Takegami, Misa] Natl Cerebral & Cardiovasc Ctr, Dept Prevalence Med & Epidemiol Informat, Osaka, Japan.
C3 Kobe University; Kyoto University; Fukushima Medical University;
   National Cerebral & Cardiovascular Center - Japan
RP Ono, R (corresponding author), Kobe Univ, Grad Sch Hlth Sci, Dept Community Hlth Sci, Suma Ku, 7-10-2 Tomogaoka, Kobe, Hyogo 6540142, Japan.
EM ono@phoenix.kobe-u.ac.jp
RI Hayashino, Yasuaki/AAA-8637-2022; Yamazaki, Shin-ichi/H-8089-2018;
   Otani, Koji/ABF-8564-2020
OI ONO, Rei/0000-0002-0176-2870; Otani, Koji/0000-0001-8409-9623;
   Hayashino, Yasuaki/0000-0002-2932-8478
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Amigoni S, 2000, MATURITAS, V34, P25, DOI 10.1016/S0378-5122(99)00089-4
   [Anonymous], 2002, Journal of Health and Welfare Statistics
   [Anonymous], GUID DAT PROC AN INT
   Arai H, 2006, J ATHEROSCLER THROMB, V13, P202, DOI 10.5551/jat.13.202
   Bjorck-van Dijken C, 2008, J REHABIL MED, V40, P864, DOI 10.2340/16501977-0273
   East C, 2010, METAB SYNDR RELAT D, V8, P451, DOI 10.1089/met.2010.0017
   Fanuele JC, 2000, SPINE, V25, P1509, DOI 10.1097/00007632-200006150-00009
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Gu DF, 2005, LANCET, V365, P1398, DOI 10.1016/S0140-6736(05)66375-1
   HELIOVAARA M, 1989, ANN MED, V21, P327, DOI 10.3109/07853898909149216
   Hildrum B, 2007, BMC PUBLIC HEALTH, V7, DOI 10.1186/1471-2458-7-220
   Izumi Y, 2007, AM J HYPERTENS, V20, P1045, DOI 10.1016/j.amjhyper.2007.04.019
   Japanese Ministry of Health Labour and Welfare Health Service Bureau General Affairs Division, SUMM NAT HLTH NUTR S
   Japanese Ministry of Health Labour and Welfare Minister's Secretariat Statistics and Information Dept, 2007, SUMM COMPR SURV LIV
   Konno S, 2007, BMC MUSCULOSKEL DIS, V8, DOI 10.1186/1471-2474-8-102
   Laaksonen DE, 2002, DIABETES CARE, V25, P1612, DOI 10.2337/diacare.25.9.1612
   Leboeuf-Yde C, 1999, SPINE, V24, P1463, DOI 10.1097/00007632-199907150-00012
   Loevinger BL, 2007, METABOLISM, V56, P87, DOI 10.1016/j.metabol.2006.09.001
   Lorenzo C, 2003, DIABETES CARE, V26, P3153, DOI 10.2337/diacare.26.11.3153
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Manabe T, 2003, EUR SPINE J, V12, P596, DOI 10.1007/s00586-003-0585-0
   Mäntyselkä P, 2010, BMC MUSCULOSKEL DIS, V11, DOI 10.1186/1471-2474-11-171
   Matsuzawa Y., 2005, NIPPON NAIKA GAKKAI, V94, P794
   Nakamura K, 2009, J ORTHOP SCI, V14, P1, DOI 10.1007/s00776-008-1302-y
   Ninomiya T, 2007, STROKE, V38, P2063, DOI 10.1161/STROKEAHA.106.479642
   Oksuz E, 2006, SPINE, V31, pE968, DOI 10.1097/01.brs.0000247787.25382.3c
   PAPAGEORGIOU AC, 1995, SPINE, V20, P1889, DOI 10.1097/00007632-199509000-00009
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Pincus Tamar, 2002, Spine (Phila Pa 1976), V27, pE109, DOI 10.1097/00007632-200203010-00017
   Shiri R, 2010, AM J EPIDEMIOL, V171, P135, DOI 10.1093/aje/kwp356
   Strine TW, 2007, ARTHRIT RHEUM-ARTHR, V57, P656, DOI 10.1002/art.22684
   Syed F, 2005, BIOCHEM BIOPH RES CO, V328, P688, DOI 10.1016/j.bbrc.2004.11.097
   Webb R, 2003, SPINE, V28, P1195, DOI 10.1097/00007632-200306010-00021
   Yamazaki Shin, 2005, Health Qual Life Outcomes, V3, P48
   Zhu K, 2007, SPINE, V32, P2012, DOI 10.1097/BRS.0b013e318133fb82
NR 37
TC 22
Z9 23
U1 1
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0362-2436
EI 1528-1159
J9 SPINE
JI SPINE
PD JUN 1
PY 2012
VL 37
IS 13
BP 1130
EP 1137
DI 10.1097/BRS.0b013e31824231b8
PG 8
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Orthopedics
GA 952CF
UT WOS:000304766600014
PM 22146290
DA 2025-06-11
ER

PT J
AU Vlachakis, C
   Dragoumani, K
   Raftopoulou, S
   Mantaiou, M
   Papageorgiou, L
   Tsaniras, SC
   Megalooikonomou, V
   Vlachakis, D
AF Vlachakis, Chrisanthy
   Dragoumani, Konstantina
   Raftopoulou, Sofia
   Mantaiou, Meropi
   Papageorgiou, Louis
   Tsaniras, Spyridon Champeris
   Megalooikonomou, Vasileios
   Vlachakis, Dimitrios
TI Human Emotions on the Onset of Cardiovascular and Small Vessel Related
   Diseases
SO IN VIVO
LA English
DT Article
DE Emotional intelligence; emotions; coronary heart disease; diabetes
   melitus; obesity
ID CORONARY-HEART-DISEASE; QUALITY-OF-LIFE; TYPE-2 DIABETIC-PATIENTS; EDID
   RESEARCH CONSORTIUM; POOR GLYCEMIC CONTROL; RISK-FACTORS; DEPRESSIVE
   SYMPTOMS; METABOLIC SYNDROME; POSITIVE EMOTIONS; SOCIOECONOMIC-STATUS
AB Background/Aim: The aim of the present study was to examine the relation between understanding of emotions and cardiovascular related diseases, namely coronary heart disease, diabetes mellitus and obesity. The uniqueness of this study lies in the fact that it examined the relationship between the cardiovascular related diseases named above and the understanding of emotions in the context of Emotional Intelligence (EI). Patients and Methods: The study was conducted in 300 participants during a 3 year period. All participants completed a self-report questionnaire, assessing various aspects of EI, such as self-emotion appraisal, other emotion appraisal, emotion regulation and use of emotions. As hypothesized, coronary heart disease is a prognostic factor of regulation of emotions. Results: The present study is an attempt to examine the relation between emotional understanding and cardiovascular related diseases, namely coronary heart disease, diabetes mellitus and obesity. Establishing which diseases are independent risk factors for the understanding of emotions, could have a significant impact on emotional health, through the treatment of these cardiovascular related diseases. Emotions were studied within the theoretical context of Emotional Intelligence (EI), which affects people's physical and mental health. Conclusion: The results of this study emphasize on the relationship of cardiovascular related diseases and psychological characteristics, such as anxiety and anger, being aspects of EI. Additionally, this work fills a gap in the relevant Greek literature, as a first attempt to examine the correlation of EI with cardiovascular related diseases.
C1 [Vlachakis, Chrisanthy; Dragoumani, Konstantina; Raftopoulou, Sofia; Papageorgiou, Louis; Vlachakis, Dimitrios] Agr Univ Athens, Sch Food Biotechnol & Dev, Dept Biotechnol, Lab Genet, Athens, Greece.
   [Raftopoulou, Sofia; Mantaiou, Meropi] Sotiria Chest Dis Hosp, Athens, Greece.
   [Raftopoulou, Sofia; Vlachakis, Dimitrios] Acad Athens, Biomed Res Fdn, Ctr Clin Expt Surg & Translat Res, Div Endocrinol & Metab, Athens, Greece.
   [Papageorgiou, Louis] Natl & Kapodistrian Univ Athens, Dept Informat & Telecommun, Univ Campus, Athens, Greece.
   [Tsaniras, Spyridon Champeris] Univ Patras, Med Sch, Dept Physiol, Patras, Greece.
   [Megalooikonomou, Vasileios; Vlachakis, Dimitrios] Univ Patras, Sch Engn, Comp Engn & Informat Dept, Patras, Greece.
C3 Agricultural University of Athens; Academy of Athens; National &
   Kapodistrian University of Athens; University of Patras; University of
   Patras
RP Vlachakis, D (corresponding author), Agr Univ Athens, Sch Food Biotechnol & Dev, Dept Biotechnol, Lab Genet, Athens, Greece.
EM dimvl@aua.gr
RI DRAGOUMANI, KONSTANTINA/GWU-6137-2022; Vlachakis, Dimitrios/O-4323-2018;
   Champeris Tsaniras, Spyridon/F-1187-2014
OI Vlachakis, Dimitrios/0000-0003-1823-6102; Papageorgiou,
   Louis/0000-0001-9577-9923; Champeris Tsaniras,
   Spyridon/0000-0002-4960-9314; Dragoumani,
   Konstantina/0009-0001-8388-6964
FU FrailSafe Project [H2020-PHC-21-2015-690140]; European Commission under
   the Horizon 2020 research and innovation programme
FX The research reported in the present paper was partially supported by
   the FrailSafe Project (H2020-PHC-21-2015-690140) "Sensing and predictive
   treatment of frailty and associated co-morbidities using advanced
   personalized models and advanced interventions", co-funded by the
   European Commission under the Horizon 2020 research and innovation
   programme.
CR ABRAHAM SF, 1982, PSYCHOL MED, V12, P625, DOI 10.1017/S0033291700055732
   Adili F, 2006, ANN NY ACAD SCI, V1084, P329, DOI 10.1196/annals.1372.016
   [Anonymous], BARON EMOTIONAL QUOT
   [Anonymous], J MOL BIOCH
   [Anonymous], J MOL BIOCH
   [Anonymous], J AM GERIATR SOC
   [Anonymous], BASIC CLIN NEUROCARD
   [Anonymous], LUNG BLOOD DIS
   Aslan S., 2008, World Applied Sciences Journal, V4, P430
   Aspinwall LG, 1997, PSYCHOL BULL, V121, P417, DOI 10.1037//0033-2909.121.3.417
   Austin EJ, 2005, PERS INDIV DIFFER, V38, P547, DOI 10.1016/j.paid.2004.05.009
   Barak Y, 2017, CANCER GENOM PROTEOM, V14, P403, DOI 10.21873/cgp.20050
   Baron-Cohen S, 1998, NATURE, V392, P459, DOI 10.1038/33076
   Barrington DS, 2010, OBESITY, V18, P422, DOI 10.1038/oby.2009.212
   Beverly EA, 2011, DIABETES CARE, V34, P1086, DOI 10.2337/dc10-2298
   Beydoun MA, 2009, AM J CLIN NUTR, V90, P1084, DOI 10.3945/ajcn.2009.27782
   Boulanger L, 2009, BMC HEALTH SERV RES, V9, DOI 10.1186/1472-6963-9-111
   Boutoille D, 2008, FOOT ANKLE INT, V29, P1074, DOI 10.3113/FAI.2008.1074
   Boyatzis R.E., 1995, INNOVATION PROFESSIO
   Bruno A, 2014, IN VIVO, V28, P973
   Bulló M, 2011, PREV MED, V53, P155, DOI 10.1016/j.ypmed.2011.06.008
   CARABELLESE C, 1993, J AM GERIATR SOC, V41, P401, DOI 10.1111/j.1532-5415.1993.tb06948.x
   Carney RM, 2005, PSYCHOSOM MED, V67, pS29, DOI 10.1097/01.psy.0000162254.61556.d5
   Cartwright M, 2003, HEALTH PSYCHOL, V22, P362, DOI 10.1037/0278-6133.22.4.362
   Caspi A, 2005, ANNU REV PSYCHOL, V56, P453, DOI 10.1146/annurev.psych.55.090902.141913
   Cha W, 2014, ANTICANCER RES, V34, P1731
   Chazova TE, 2007, KARDIOLOGIYA, V47, P10
   Chida Y, 2009, J AM COLL CARDIOL, V53, P936, DOI 10.1016/j.jacc.2008.11.044
   CHRISTENSEN L, 1993, INT J EAT DISORDER, V14, P171, DOI 10.1002/1098-108X(199309)14:2<171::AID-EAT2260140207>3.0.CO;2-U
   Ciarrochi J, 2001, PERS INDIV DIFFER, V31, P1105, DOI 10.1016/S0191-8869(00)00207-5
   Cohen S, 2003, PSYCHOSOM MED, V65, P652, DOI 10.1097/01.PSY.0000077508.57784.DA
   Craig AD, 2005, TRENDS COGN SCI, V9, P566, DOI 10.1016/j.tics.2005.10.005
   Currie J, 2009, J ECON LIT, V47, P87, DOI 10.1257/jel.47.1.87
   Daniels GE, 1939, PSYCHOSOM MED, V1, P527, DOI 10.1097/00006842-193910000-00006
   Daniels GE, 1944, PSYCHIATR, V7, P121, DOI 10.1080/00332747.1944.11022494
   Davidson KW, 2010, EUR HEART J, V31, P1065, DOI 10.1093/eurheartj/ehp603
   de Groot M, 2001, PSYCHOSOM MED, V63, P619, DOI 10.1097/00006842-200107000-00015
   De Vogli R, 2007, ARCH INTERN MED, V167, P1951, DOI 10.1001/archinte.167.18.1951
   Denollet J, 1998, CIRCULATION, V97, P167, DOI 10.1161/01.CIR.97.2.167
   Diniz A, 2016, OPHTHALMOLOGY, V123, P754, DOI 10.1016/j.ophtha.2015.12.014
   Eaker ED, 2004, AM J EPIDEMIOL, V159, P950, DOI 10.1093/aje/kwh127
   Egede LE, 2005, CURR DIABETES REV, V1, P235, DOI 10.2174/157339905774574356
   ENGEL GL, 1971, ANN INTERN MED, V74, P771, DOI 10.7326/0003-4819-74-5-771
   Everson SA, 1997, BRIT MED J, V314, P553, DOI 10.1136/bmj.314.7080.553
   EYSENCK HJ, 1988, BRIT J MED PSYCHOL, V61, P57, DOI 10.1111/j.2044-8341.1988.tb02765.x
   Finucane MM, 2011, LANCET, V377, P557, DOI 10.1016/S0140-6736(10)62037-5
   Fredrickson BL, 1998, COGNITION EMOTION, V12, P191
   Fredrickson BL, 2001, AM PSYCHOL, V56, P218, DOI 10.1037/0003-066X.56.3.218
   Fredrickson BL, 2000, MOTIV EMOTION, V24, P237, DOI 10.1023/A:1010796329158
   Goldston K, 2008, CLIN PSYCHOL REV, V28, P288, DOI 10.1016/j.cpr.2007.05.005
   Goleman D., 2020, Emotional intelligence: Why it can matter more than IQ
   Gonzalez JS, 2008, DIABETIC MED, V25, P1102, DOI 10.1111/j.1464-5491.2008.02535.x
   Gonzalez JS, 2007, DIABETES CARE, V30, P2222, DOI 10.2337/dc07-0158
   Gordon-Larsen P, 2004, AM J CLIN NUTR, V80, P569
   Gouni-Berthold I, 2009, CURR VASC PHARMACOL, V7, P414, DOI 10.3390/nu5083005
   Haines H, 2001, HEART, V85, P385, DOI 10.1136/heart.85.4.385
   Hayman KJ, 2007, OPTOMETRY VISION SCI, V84, P1024, DOI 10.1097/OPX.0b013e318157a6b1
   Hermanns N, 2005, DIABETIC MED, V22, P293, DOI 10.1111/j.1464-5491.2005.01414.x
   Isen A.M., 1999, HDB COGNITION EMOTIO, P521, DOI DOI 10.1002/0470013494.CH25
   Kafetsios K, 2008, PERS INDIV DIFFER, V44, P712, DOI 10.1016/j.paid.2007.10.004
   KAPLAN HI, 1957, J NERV MENT DIS, V125, P181, DOI 10.1097/00005053-195704000-00004
   Katon WJ, 2004, ARCH GEN PSYCHIAT, V61, P1042, DOI 10.1001/archpsyc.61.10.1042
   Kemp AH, 2010, BIOL PSYCHIAT, V67, P1067, DOI [10.1016/j.biopsych.2009.12.012, 10.1016/j.biopsych.2009.11.019]
   Kenardy J, 1996, AUST NZ J PSYCHIAT, V30, P839, DOI 10.3109/00048679609065053
   KNOX SS, 1993, J PSYCHOSOM RES, V37, P709, DOI 10.1016/0022-3999(93)90099-2
   Koelsch S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031441
   KOENIGSBERG HW, 1993, AM J PSYCHIAT, V150, P1114
   Kokoszka A, 2009, EUR PSYCHIAT, V24, P425, DOI 10.1016/j.eurpsy.2009.04.002
   KRANTZ DS, 1984, PSYCHOL BULL, V96, P435, DOI 10.1037/0033-2909.96.3.435
   Kravvariti E., 2010, Global Journal of Health Science, V2, P127, DOI [10.5539/gjhs.v2n1p127, DOI 10.5539/GJHS.V2N1P127]
   Kuper H, 2003, J EPIDEMIOL COMMUN H, V57, P147, DOI 10.1136/jech.57.2.147
   Kuper H, 2002, OCCUP ENVIRON MED, V59, P777, DOI 10.1136/oem.59.11.777
   Kyrozis A, 2009, J PSYCHIATR RES, V43, P763, DOI 10.1016/j.jpsychires.2008.09.003
   Laeng B, 2012, PERSPECT PSYCHOL SCI, V7, P18, DOI 10.1177/1745691611427305
   Lawder R, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-330
   LEIKER M, 1988, BEHAV MED, V14, P129, DOI 10.1080/08964289.1988.9935136
   LITTMAN AB, 1993, PSYCHOTHER PSYCHOSOM, V60, P148, DOI 10.1159/000288689
   Lustman PJ, 2000, DIABETES CARE, V23, P934, DOI 10.2337/diacare.23.7.934
   Macht M, 2000, APPETITE, V35, P65, DOI 10.1006/appe.2000.0325
   Macht Michael, 2005, Eat Behav, V6, P109, DOI 10.1016/j.eatbeh.2004.09.001
   Marcellini F, 2009, ARCH GERONTOL GERIAT, V49, P195, DOI 10.1016/j.archger.2009.09.029
   Martyn-Nemeth P, 2009, RES NURS HEALTH, V32, P96, DOI 10.1002/nur.20304
   Matthews G., 2000, The Handbook of Emotional Intelligence
   Mavroveli S, 2011, BRIT J EDUC PSYCHOL, V81, P112, DOI 10.1348/2044-8279.002009
   McElroy SL, 2004, J CLIN PSYCHIAT, V65, P634
   McEwen BS, 2010, ANN NY ACAD SCI, V1186, P190, DOI 10.1111/j.1749-6632.2009.05331.x
   Meyer C, 1998, W S CLIN NEUROBIOL, V4, P271
   Miller AH, 1998, PSYCHIAT CLIN N AM, V21, P443, DOI 10.1016/S0193-953X(05)70015-0
   Miller TQ, 1996, PSYCHOL BULL, V119, P322, DOI 10.1037/0033-2909.119.2.322
   Moon A, 2009, COGNITION EMOTION, V23, P417, DOI 10.1080/02699930801961798
   Moreira RO, 2009, ARQ BRAS ENDOCRINOL, V53, P1103, DOI 10.1590/S0004-27302009000900007
   Musselman DL, 1998, ARCH GEN PSYCHIAT, V55, P580, DOI 10.1001/archpsyc.55.7.580
   Niaura R, 2002, HEALTH PSYCHOL, V21, P588, DOI 10.1037//0278-6133.21.6.588
   O'Brien RM, 2007, QUAL QUANT, V41, P673, DOI 10.1007/s11135-006-9018-6
   O'Donnel CJ, 2008, REV ESP CARDIOL, V61, P299, DOI 10.1016/S1885-5857(08)60118-8
   Ollonen P, 2005, ANTICANCER RES, V25, P531
   Orth-Gomér K, 2000, JAMA-J AM MED ASSOC, V284, P3008, DOI 10.1001/jama.284.23.3008
   Ozer DJ, 2006, ANNU REV PSYCHOL, V57, P401, DOI 10.1146/annurev.psych.57.102904.190127
   Ozier AD, 2008, J AM DIET ASSOC, V108, P49, DOI 10.1016/j.jada.2007.10.011
   Panagiotakos DB, 2002, PREV MED, V35, P548, DOI 10.1006/pmed.2002.1108
   Peyrot M, 1997, DIABETES CARE, V20, P585, DOI 10.2337/diacare.20.4.585
   Pibernik-Okanovic M, 2005, DIABETIC MED, V22, P942, DOI 10.1111/j.1464-5491.2005.01528.x
   Ranabir Salam, 2011, Indian J Endocrinol Metab, V15 Suppl 3, pS188, DOI [10.4103/2230-8210.77573, 10.4103/2230-8210.84862]
   Reichenberg A, 2001, ARCH GEN PSYCHIAT, V58, P445, DOI 10.1001/archpsyc.58.5.445
   Rice MC, 2010, AGING MENT HEALTH, V14, P405, DOI 10.1080/13607860903586185
   Rose M, 2002, DIABETES CARE, V25, P35, DOI 10.2337/diacare.25.1.35
   Rozanski A, 1999, CIRCULATION, V99, P2192, DOI 10.1161/01.CIR.99.16.2192
   Rugulies R, 2002, AM J PREV MED, V23, P51, DOI 10.1016/S0749-3797(02)00439-7
   Russek LG, 1997, J BEHAV MED, V20, P1, DOI 10.1023/A:1025525428213
   Saaddine JB, 2006, ANN INTERN MED, V144, P465, DOI 10.7326/0003-4819-144-7-200604040-00005
   Scanlon PJ, 1999, CIRCULATION, V99, P2345, DOI 10.1161/01.CIR.99.17.2345
   SCHERWITZ LW, 1992, AM J EPIDEMIOL, V136, P136, DOI 10.1093/oxfordjournals.aje.a116480
   Schram MT, 2009, CURR DIABETES REV, V5, P112, DOI 10.2174/157339909788166828
   Siegling AB, 2015, J PSYCHOEDUC ASSESS, V33, P57, DOI 10.1177/0734282914550385
   Steptoe A, 2000, ANN MED, V32, P371, DOI 10.3109/07853890008995940
   Stewart-Knox BJ, 2005, P NUTR SOC, V64, P363, DOI 10.1079/PNS2005444
   STONE AA, 1987, J PERS SOC PSYCHOL, V52, P988, DOI 10.1037/0022-3514.52.5.988
   Thomas J, 2003, DIABETES CARE, V26, P2311, DOI 10.2337/diacare.26.8.2311
   TIBBLIN G, 1990, Scandinavian Journal of Primary Health Care, V8, P9, DOI 10.3109/02813439008994923
   Tindle HA, 2009, CIRCULATION, V120, P656, DOI 10.1161/CIRCULATIONAHA.108.827642
   Toker S, 2008, DEPRESS ANXIETY, V25, P661, DOI 10.1002/da.20379
   Tunstall-Pedoe H, 2001, BMJ-BRIT MED J, V323, P695, DOI 10.1136/bmj.323.7314.695a
   Urry HL, 2004, PSYCHOL SCI, V15, P367, DOI 10.1111/j.0956-7976.2004.00686.x
   Van der Kooy K, 2007, INT J GERIATR PSYCH, V22, P613, DOI 10.1002/gps.1723
   van der Ven NCW, 2005, PATIENT EDUC COUNS, V56, P313, DOI 10.1016/j.pec.2004.03.005
   Végh D, 2017, ANTICANCER RES, V37, P1853, DOI 10.21873/anticanres.11521
   Wallis DJ, 2004, APPETITE, V43, P39, DOI 10.1016/j.appet.2004.02.001
   Weber-Hamann B, 2002, PSYCHOSOM MED, V64, P274, DOI 10.1097/00006842-200203000-00010
   Winkley K, 2006, BMJ-BRIT MED J, V333, P65, DOI 10.1136/bmj.38874.652569.55
   Winkley K, 2009, J AM PODIAT MED ASSN, V99, P406, DOI 10.7547/0990406
   YANNUZZI LA, 1987, RETINA-J RET VIT DIS, V7, P111, DOI 10.1097/00006982-198700720-00009
   Yanovski S Z, 1993, Obes Res, V1, P306
   Yau YHC, 2013, MINERVA ENDOCRINOL, V38, P255
   Zaninotto P, 2010, OBESITY, V18, P1981, DOI 10.1038/oby.2009.497
NR 134
TC 9
Z9 13
U1 0
U2 12
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22,
   ATHENS 19014, GREECE
SN 0258-851X
EI 1791-7549
J9 IN VIVO
JI In Vivo
PD JUL-AUG
PY 2018
VL 32
IS 4
BP 859
EP 870
DI 10.21873/invivo.11320
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA GK5RJ
UT WOS:000436233800023
PM 29936471
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Santoro, N
   Torrens, J
   Crawford, S
   Allsworth, JE
   Finkelstein, JS
   Gold, EB
   Korenman, S
   Lasley, WL
   Luborsky, JL
   McConnell, D
   Sowers, MF
   Weiss, G
AF Santoro, N
   Torrens, J
   Crawford, S
   Allsworth, JE
   Finkelstein, JS
   Gold, EB
   Korenman, S
   Lasley, WL
   Luborsky, JL
   McConnell, D
   Sowers, MF
   Weiss, G
TI Correlates of circulating androgens in mid-life women: The study of
   women's health across the nation
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID DEHYDROEPIANDROSTERONE-SULFATE; PERIMENOPAUSAL WOMEN;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; BODY-COMPOSITION; SEXUAL
   FUNCTION; SURVEY SF-36; TESTOSTERONE; MENOPAUSE; HORMONES
AB Context: Androgens influence sexual differentiation and behavior, body composition, and physical functioning in men, but their role in women is less well understood. Because circulating androgens decline with age, the use of androgen supplementation for women to improve health and well-being has been increasing.
   Objective: The aim of this study was to assess the association between androgens and a variety of end points thought to be affected by androgens.
   Design: In a community-based baseline cohort of women aged 42-52 yr from the Study of Women's Health Across the Nation, we measured circulating testosterone (T), dehydroepiandrosterone sulfate, and SHBG, and calculated a free androgen index (FAI) in 2961 women.
   Main Outcome Measures: Correlations of androgen measures with each other and with body mass index, waist circumference, and waist-hip ratio were computed, and odds ratios (OR) were estimated for the categorical outcomes of functional limitations, functional status, self-reported health, scores indicative of depressed mood, quality of life, sexual desire and arousal, and the presence of the metabolic syndrome.
   Results: Androgens, and particularly SHBG, were associated most strongly with body mass index, waist circumference, and waist-hip ratio. SHBG was associated prominently inversely with the metabolic syndrome (OR = 0.32; 95% confidence interval = 0.26-0.39), which was present in 17% of women at baseline. Dehydroepiandrosterone sulfate was associated modestly with functional status and self-reported health. T was associated minimally with increased sexual desire (OR = 1.09; 95% confidence interval = 1.00-1.18). The association of FAI with self-reported health and depressive symptomatology based on the Center for Epidemiologic Studies Depression Scale score was explained more by T than by SHBG, whereas the association of FAI with sexual arousal and metabolic syndrome was due more to SHBG than to T.
   Conclusions: Circulating SHBG and androgens are most strongly associated with physical characteristics and the metabolic syndrome in women in this community-based cohort. Androgens are related weakly to physical functioning and other symptoms to which they commonly are attributed, such as sexual desire, sexual arousal, and well-being.
C1 Albert Einstein Coll Med, Dept Obstet Gynecol & Womens Hlth, Div Reprod Endocrinol, Bronx, NY 10461 USA.
   Massachusetts Gen Hosp, Boston, MA 02114 USA.
   Rush Univ, Rush Presbyterian St Lukes Med Ctr, Chicago, IL 60612 USA.
   Univ Calif Davis, Davis, CA 95616 USA.
   Univ Calif Los Angeles, Los Angeles, CA 90095 USA.
   Univ Med & Dent New Jersey, New Jersey Med Sch, Newark, NJ 07103 USA.
   Univ Michigan, Ann Arbor, MI 48104 USA.
   New England Res Inst, Watertown, MA 02472 USA.
C3 Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva
   University; Harvard University; Harvard University Medical Affiliates;
   Massachusetts General Hospital; Rush University; University of
   California System; University of California Davis; University of
   California System; University of California Los Angeles; Rutgers
   University System; Rutgers University New Brunswick; Rutgers University
   Biomedical & Health Sciences; University of Michigan System; University
   of Michigan; HealthCore, Inc
RP Albert Einstein Coll Med, Dept Obstet Gynecol & Womens Hlth, Div Reprod Endocrinol, 1300 Morris Pk Ave,Mazer 316, Bronx, NY 10461 USA.
EM glicktoro@aol.com
RI Finkelstein, Joel/M-6463-2019; Allsworth, Jenifer/J-2475-2019
OI Allsworth, Jenifer/0000-0001-6559-8638
CR Abma J C, 1997, Vital Health Stat 23, P1
   ANDREWS SF, 1976, SOCIAL INDICATORS WE
   Arlt W, 1999, NEW ENGL J MED, V341, P1013, DOI 10.1056/NEJM199909303411401
   Avis N E, 1995, J Am Med Womens Assoc (1972), V50, P45
   Balkau B, 2002, DIABETES METAB, V28, P364
   Barnhart KT, 1999, J CLIN ENDOCR METAB, V84, P3896, DOI 10.1210/jc.84.11.3896
   Bender R, 1998, J CLIN EPIDEMIOL, V51, P809, DOI 10.1016/S0895-4356(98)00066-3
   Bhasin S, 2001, AM J PHYSIOL-ENDOC M, V281, pE1172, DOI 10.1152/ajpendo.2001.281.6.E1172
   BRAMBILLA DJ, 1994, AM J EPIDEMIOL, V140, P1091, DOI 10.1093/oxfordjournals.aje.a117209
   BRAZIER JE, 1992, BMJ-BRIT MED J, V305, P160, DOI 10.1136/bmj.305.6846.160
   Burger HG, 2000, J CLIN ENDOCR METAB, V85, P2832, DOI 10.1210/jc.85.8.2832
   Carr MC, 2003, J CLIN ENDOCR METAB, V88, P2404, DOI 10.1210/jc.2003-030242
   Cawood EHH, 1996, PSYCHOL MED, V26, P925, DOI 10.1017/S0033291700035261
   *CDCP, 1994, DHHS PUB
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   COGHLIN J, 1989, AM J EPIDEMIOL, V130, P696, DOI 10.1093/oxfordjournals.aje.a115391
   COMSTOCK GW, 1976, PSYCHOL MED, V6, P551, DOI 10.1017/S0033291700018171
   Dennerstein L, 2002, FERTIL STERIL, V77, pS42
   Dobs AS, 2002, J CLIN ENDOCR METAB, V87, P1509, DOI 10.1210/jc.87.4.1509
   Dudley E C, 1998, Climacteric, V1, P18, DOI 10.3109/13697139809080677
   FERRIS BG, 1978, AM REV RESPIR DIS, V118, P1
   Flegal KM, 1998, INT J OBESITY, V22, P39, DOI 10.1038/sj.ijo.0800541
   Floter A, 1997, MENOPAUSE, V4, P95
   Goldstat R, 2003, MENOPAUSE, V10, P390, DOI 10.1097/01.GME.0000060256.03945.20
   Gruenewald DA, 2003, J AM GERIATR SOC, V51, P101, DOI 10.1034/j.1601-5215.2002.51018.x
   Guthrie JR, 2004, MENOPAUSE, V11, P315, DOI 10.1097/01.GME.0000094208.15096.62
   Guthrie JR, 2003, FERTIL STERIL, V79, P1335, DOI 10.1016/S0015-0282(03)00361-3
   Hosmer D, 1989, Applied Logistic Regression
   Labrie F, 1997, J CLIN ENDOCR METAB, V82, P2396, DOI 10.1210/jc.82.8.2396
   Labrie F, 1998, STEROIDS, V63, P322, DOI 10.1016/S0039-128X(98)00007-5
   LAUMANN EO, 1994, FAM PLANN PERSPECT, V26, P34, DOI 10.2307/2136095
   Lobo RA, 2003, FERTIL STERIL, V79, P1341, DOI 10.1016/S0015-0282(03)00358-3
   MARIN G, 1987, HISPANIC J BEHAV SCI, V9, P183, DOI 10.1177/07399863870092005
   MCCOY N, 1985, ARCH SEX BEHAV, V14, P385, DOI 10.1007/BF01542000
   MCHORNEY CA, 1993, MED CARE, V31, P247, DOI 10.1097/00005650-199303000-00006
   MCHORNEY CA, 1994, MED CARE, V32, P40, DOI 10.1097/00005650-199401000-00004
   McKinlay SM, 1996, MATURITAS, V23, P137, DOI 10.1016/0378-5122(95)00985-X
   Mogul Harriette R, 2002, Heart Dis, V4, P78
   Morales AJ, 1998, CLIN ENDOCRINOL, V49, P421, DOI 10.1046/j.1365-2265.1998.00507.x
   Mushayandebvu T, 1996, FERTIL STERIL, V65, P721, DOI 10.1016/S0015-0282(16)58203-X
   Nakhla AM, 1999, STEROIDS, V64, P213, DOI 10.1016/S0039-128X(98)00084-1
   ORENTREICH N, 1984, J CLIN ENDOCR METAB, V59, P551, DOI 10.1210/jcem-59-3-551
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Randolph JF, 2003, J CLIN ENDOCR METAB, V88, P1516, DOI 10.1210/jc.2002-020777
   ROBERTS RE, 1983, AM J PSYCHIAT, V140, P41
   Rosner W, 1998, STEROIDS, V63, P278, DOI 10.1016/S0039-128X(98)00017-8
   Shifren JL, 2000, NEW ENGL J MED, V343, P682, DOI 10.1056/NEJM200009073431002
   Soules Michael R., 2001, Fertility and Sterility, V76, P874, DOI 10.1016/S0015-0282(01)02909-0
   Sowers M, 2003, J CLIN ENDOCR METAB, V88, P4904, DOI 10.1210/jc.2003-030350
   Sowers M.F., 2000, Menopause: biology and pathobiology, P175, DOI DOI 10.1016/B978-012453790-3/50012-3
   Thomas JL, 2001, INT J PSYCHIAT MED, V31, P25, DOI 10.2190/FUFR-PK9F-6U10-JXRK
   Valanis BG, 2000, ARCH FAM MED, V9, P843, DOI 10.1001/archfami.9.9.843
   Vasan RS, 2001, NEW ENGL J MED, V345, P1291, DOI 10.1056/NEJMoa003417
   WARE JE, 1995, MED CARE, V33, pAS264, DOI 10.1097/00005650-199501001-00005
   WARE JE, 1992, MED CARE, V30, P473, DOI 10.1097/00005650-199206000-00002
NR 55
TC 185
Z9 197
U1 0
U2 9
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD AUG
PY 2005
VL 90
IS 8
BP 4836
EP 4845
DI 10.1210/jc.2004-2063
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA 953HZ
UT WOS:000231068500061
PM 15840738
OA Bronze
DA 2025-06-11
ER

PT J
AU Marquine, MJ
   Gallo, LC
   Tarraf, W
   Wu, BS
   Moore, AA
   Vásquez, PM
   Talavera, G
   Allison, M
   Muñoz, E
   Isasi, CR
   Perreira, KM
   Bigornia, SJ
   Daviglus, M
   Estrella, ML
   Zeng, DL
   González, HM
AF Marquine, Maria J.
   Gallo, Linda C.
   Tarraf, Wassim
   Wu, Benson
   Moore, Alison A.
   Vasquez, Priscilla M.
   Talavera, Gregory
   Allison, Matthew
   Munoz, Elizabeth
   Isasi, Carmen R.
   Perreira, Krista M.
   Bigornia, Sherman J.
   Daviglus, Martha
   Estrella, Mayra L.
   Zeng, Donglin
   Gonzalez, Hector M.
TI The Association of Stress, Metabolic Syndrome, and Systemic Inflammation
   With Neurocognitive Function in the Hispanic Community Health
   Study/Study of Latinos and Its Sociocultural Ancillary Study
SO JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL
   SCIENCES
LA English
DT Article
DE Cardiovascular disease; Cognition; Minority and diverse populations
ID CARDIOVASCULAR-DISEASE; COGNITIVE FUNCTION; TRAUMATIC STRESS;
   RISK-FACTOR; PREVALENCE; DESIGN; ADULTS
AB Objectives Identifying sociocultural correlates of neurocognitive dysfunction among Hispanics/Latinos, and their underlying biological pathways, is crucial for understanding disparities in Alzheimer's disease and related dementias. We examined cross-sectional associations between stress and neurocognition, and the role that metabolic syndrome (MetS) and systemic inflammation might play in these associations. Method Participants included 3,045 adults aged 45-75 (56% female, education 0-20+ years, 86% Spanish-speaking, 23% U.S.-born), enrolled in the Hispanic Community Health Study/Study of Latinos and its Sociocultural Ancillary Study. Global neurocognition was the primary outcome and operationalized as the average of the z scores of measures of learning and memory, word fluency, and processing speed. Stress measures included self-report assessments of stress appraisal (perceived and acculturative stress) and exposure to chronic and traumatic stressors. MetS was defined via established criteria including waist circumference, high blood pressure, elevated triglycerides, fasting plasma glucose, and high levels of high-density lipoprotein cholesterol. Systemic inflammation was represented by high-sensitivity C-reactive protein (hs-CRP). Results Separate survey multivariable linear regression models adjusting for covariates showed that higher perceived (b = -0.004, SE = 0.002, p < .05) and acculturative stress (b = -0.004, SE = 0.001, p < .0001) were significantly associated with worse global neurocognition, while lifetime exposure to traumatic stressors was associated with better global neurocognition (b = 0.034, SE = 0.009, p < .001). Neither MetS nor hs-CRP were notable pathways in the association between stress and neurocognition; rather, they were both independently associated with worse neurocognition in models including stress measures (ps < .05). Discussion These cross-sectional analyses suggest that stress appraisal, MetS, and systemic inflammation may be targets to reduce neurocognitive dysfunction among Hispanics/Latinos.
C1 [Marquine, Maria J.; Moore, Alison A.] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA.
   [Marquine, Maria J.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
   [Gallo, Linda C.; Talavera, Gregory] San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA.
   [Tarraf, Wassim] Wayne State Univ, Inst Gerontol, Dept Healthcare Sci, Detroit, MI 48202 USA.
   [Wu, Benson; Gonzalez, Hector M.] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA.
   [Vasquez, Priscilla M.] Charles R Drew Univ Med & Sci, Dept Urban Publ Hlth, 1621 E 120th St, Los Angeles, CA 90059 USA.
   [Allison, Matthew] Univ Calif San Diego, Dept Family Med, La Jolla, CA 92093 USA.
   [Munoz, Elizabeth] Univ Texas Austin, Dept Human Dev & Family Sci, Austin, TX 78712 USA.
   [Isasi, Carmen R.] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA.
   [Perreira, Krista M.] Univ N Carolina, Dept Social Med, Chapel Hill, NC 27515 USA.
   [Bigornia, Sherman J.] Univ New Hampshire, Dept Agr Nutr & Food Syst, Durham, NH 03824 USA.
   [Daviglus, Martha; Estrella, Mayra L.] Univ Illinois, Inst Minor Hlth Res, Chicago, IL USA.
   [Zeng, Donglin] Univ N Carolina, Dept Biostat, Chapel Hill, NC 27515 USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   California State University System; San Diego State University; Wayne
   State University; University of California System; University of
   California San Diego; Charles R. Drew University of Medicine & Science;
   University of California System; University of California San Diego;
   University of Texas System; University of Texas Austin; Montefiore
   Medical Center; Albert Einstein College of Medicine; Yeshiva University;
   University of North Carolina; University of North Carolina Chapel Hill;
   University System Of New Hampshire; University of New Hampshire;
   University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of North Carolina;
   University of North Carolina Chapel Hill
RP Marquine, MJ (corresponding author), Univ Calif San Diego, Dept Med, Div Geriatr Gerontol & Palliat Care, 9500 Gilman Dr 0665, La Jolla, CA 92093 USA.
EM mmarquine@health.ucsd.edu
RI Gonzalez, Hector/AAV-7576-2021; Xu, Tianchen/AAR-4013-2021; Munoz,
   Elizabeth/F-4247-2018
OI Perreira, Krista/0000-0003-2906-0261; Munoz,
   Elizabeth/0000-0003-2152-5917; Marquine, Maria/0000-0003-2249-6628
FU National Heart, Lung, and Blood Institute
   [HHSN268201300001I/N01-HC-65233, HHSN26820 1300004I/N01-HC-65234,
   HHSN268201300002I/N01-HC-65235, HHSN268201300003I/N01-HC-65236,
   HHSN268201300005I/N01-HC-65237]; National Institute on Minority Health
   and Health Disparities; National Institute on Deafness and Other
   Communication Disorders; National Institute of Dental and Craniofacial
   Research; National Institute of Diabetes and Digestive and Kidney
   Diseases; National Institute of Neurological Disorders and Stroke;
   National Institutes of Health (NIH) Office of Dietary Supplements; NIH
   [R01AG048642, RF1AG054548, P30AG059299, DK111022-8786, P30AG062429]; 
   [RC2HL101649]; Eunice Kennedy Shriver National Institute of Child Health
   and Human Development [P2CHD050924] Funding Source: NIH RePORTER
FX The Hispanic Community Health Study/Study of Latinos is a collaborative
   study supported by contracts from the National Heart, Lung, and Blood
   Institute to the University of North Carolina
   (HHSN268201300001I/N01-HC-65233), University of Miami (HHSN26820
   1300004I/N01-HC-65234), Albert Einstein College of Medicine
   (HHSN268201300002I/N01-HC-65235), University of Illinois at Chicago
   (HHSN268201300003I/N01-HC-65236 Northwestern University), and San Diego
   State University (HHSN268201300005I/N01-HC-65237). The following
   institutes/centers/offices have contributed to the HCHS/SOL through a
   transfer of funds to the National Heart, Lung, and Blood Institute:
   National Institute on Minority Health and Health Disparities, National
   Institute on Deafness and Other Communication Disorders, National
   Institute of Dental and Craniofacial Research, National Institute of
   Diabetes and Digestive and Kidney Diseases, National Institute of
   Neurological Disorders and Stroke, and National Institutes of Health
   (NIH) Office of Dietary Supplements. The HCHS/SOL Socio-Cultural
   Ancillary Study was supported by grant number RC2HL101649. This work was
   also supported by the following NIH grants: R01AG048642, RF1AG054548,
   P30AG059299, DK111022-8786, and P30AG062429.
CR ANDRESEN EM, 1994, AM J PREV MED, V10, P77, DOI 10.1016/S0749-3797(18)30622-6
   Benton A., 1989, Multilingual aphasia examination, V2nd Edn
   Bisht K, 2018, NEUROBIOL STRESS, V9, P9, DOI 10.1016/j.ynstr.2018.05.003
   Bromberger JT, 1996, PSYCHOL AGING, V11, P207, DOI 10.1037/0882-7974.11.2.207
   CERVANTES RC, 1990, HISPANIC J BEHAV SCI, V12, P76, DOI 10.1177/07399863900121004
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Dimsdale JE, 2008, J AM COLL CARDIOL, V51, P1237, DOI 10.1016/j.jacc.2007.12.024
   Edward USC., 2016, LATINOS ALZHEIMERS D
   Estrella ML, 2021, J ALZHEIMERS DIS, V79, P433, DOI 10.3233/JAD-200612
   Farrer LA, 1997, JAMA-J AM MED ASSOC, V278, P1349, DOI 10.1001/jama.278.16.1349
   Gallo LC, 2014, PSYCHOSOM MED, V76, P468, DOI 10.1097/PSY.0000000000000069
   Gallo LC, 2014, ETHNIC DIS, V24, P77
   González HM, 2018, DIABETES CARE, V41, P1501, DOI 10.2337/dc17-1896
   González HM, 2015, ARCH CLIN NEUROPSYCH, V30, P68, DOI 10.1093/arclin/acu066
   González HM, 2002, CLIN NEUROPSYCHOL, V16, P439, DOI 10.1076/clin.16.4.439.13908
   Gurland BJ, 1999, INT J GERIATR PSYCH, V14, P481, DOI 10.1002/(SICI)1099-1166(199906)14:6<481::AID-GPS959>3.3.CO;2-X
   Hänsel A, 2010, NEUROSCI BIOBEHAV R, V35, P115, DOI 10.1016/j.neubiorev.2009.12.012
   Hayes A. F., 2017, INTRO MEDIATION MODE
   Heiss G, 2014, DIABETES CARE, V37, P2391, DOI 10.2337/dc13-2505
   Heppner FL, 2015, NAT REV NEUROSCI, V16, P358, DOI 10.1038/nrn3880
   International Diabetes Federation, 2006, IDF CONS WORLDW DEF
   Isasi CR, 2015, ANN EPIDEMIOL, V25, P84, DOI 10.1016/j.annepidem.2014.11.002
   Juster RP, 2010, NEUROSCI BIOBEHAV R, V35, P2, DOI 10.1016/j.neubiorev.2009.10.002
   Justice NJ, 2018, NEUROBIOL STRESS, V8, P127, DOI 10.1016/j.ynstr.2018.04.002
   Lamar M, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0215378
   Linley PA, 2004, J TRAUMA STRESS, V17, P11, DOI 10.1023/B:JOTS.0000014671.27856.7e
   Lucey BP, 2020, NEUROBIOL DIS, V144, DOI 10.1016/j.nbd.2020.105031
   Lupien SJ, 2009, NAT REV NEUROSCI, V10, P434, DOI 10.1038/nrn2639
   Machado A, 2014, REV NEUROSCIENCE, V25, P785, DOI 10.1515/revneuro-2014-0035
   McCurley JL, 2015, PSYCHOPHYSIOLOGY, V52, P1071, DOI 10.1111/psyp.12430
   Monroe SM, 2008, ANNU REV CLIN PSYCHO, V4, P33, DOI 10.1146/annurev.clinpsy.4.022007.141207
   Muñoz E, 2021, J GERONTOL B-PSYCHOL, V76, pE122, DOI 10.1093/geronb/gbz144
   Muthen B. O., 1998, MPLUS USERS GUIDE
   Muthen B.O., 2017, Regression and Mediation Analysis Using Mplus
   Nguyen HT, 2012, AM J IND MED, V55, P707, DOI 10.1002/ajim.22035
   NORRIS FH, 1990, J APPL SOC PSYCHOL, V20, P1704, DOI 10.1111/j.1559-1816.1990.tb01505.x
   Pearson TA, 2003, CIRCULATION, V107, P499, DOI 10.1161/01.CIR.0000052939.59093.45
   Shivpuri S, 2012, J BEHAV MED, V35, P74, DOI 10.1007/s10865-011-9345-5
   Siervo M, 2014, J ALZHEIMERS DIS, V41, P151, DOI 10.3233/JAD-132279
   Somerfield MR, 2000, AM PSYCHOL, V55, P620, DOI 10.1037//0003-066X.55.6.620
   Sorlie PD, 2010, ANN EPIDEMIOL, V20, P629, DOI 10.1016/j.annepidem.2010.03.015
   Spielberger C. D., 1983, Manual for the State-Trait-Anxiety Inventory: STAI (form Y)
   Steptoe A, 2013, ANNU REV PUBL HEALTH, V34, P337, DOI 10.1146/annurev-publhealth-031912-114452
   Tang MX, 2001, NEUROLOGY, V56, P49, DOI 10.1212/WNL.56.1.49
   Tarraf W, 2020, J ALZHEIMERS DIS, V73, P103, DOI 10.3233/JAD-190830
   Vitaliano PP, 2005, PSYCHOL AGING, V20, P402, DOI 10.1037/0882-7974.20.3.402
   Wechsler D., 1981, Manual for the Wechsler Adult Intelligence Scale-Revised
   Yaffe K, 2007, J AM GERIATR SOC, V55, P758, DOI 10.1111/j.1532-5415.2007.01139.x
   Zahodne LB, 2019, BRAIN BEHAV IMMUN, V75, P149, DOI 10.1016/j.bbi.2018.10.002
   Zahodne LB, 2019, J GERONTOL B-PSYCHOL, V74, P409, DOI 10.1093/geronb/gbx113
NR 50
TC 7
Z9 7
U1 1
U2 12
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5014
EI 1758-5368
J9 J GERONTOL B-PSYCHOL
JI J. Gerontol. Ser. B-Psychol. Sci. Soc. Sci.
PD MAY 5
PY 2022
VL 77
IS 5
BP 860
EP 871
DI 10.1093/geronb/gbab150
EA OCT 2021
PG 12
WC Geriatrics & Gerontology; Gerontology; Psychology; Psychology,
   Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychology
GA 1A1EJ
UT WOS:000756473300001
PM 34378777
OA Green Published
DA 2025-06-11
ER

PT J
AU Lee, DE
   Clark, AK
   Shi, VY
AF Lee, Dylan E.
   Clark, Ashley K.
   Shi, Vivian Y.
TI Hidradenitis Suppurativa: Disease Burden and Etiology in Skin of Color
SO DERMATOLOGY
LA English
DT Review
DE Hidradenitis suppurativa; Disease burden; Skin of color
ID METABOLIC SYNDROME; UNITED-STATES; SOCIOECONOMIC-STATUS;
   AFRICAN-AMERICANS; RANDOMIZED-TRIAL; CHINESE FAMILY; ACNE INVERSA;
   DOUBLE-BLIND; ADALIMUMAB; HEALTH
AB Hidradenitis suppurativa (HS) is a chronic, debilitating skin disease. Although most studies on HS are conducted in largely Caucasian populations, evidence demonstrates a higher prevalence in patients with skin of color, including African and Hispanic populations. These racial subgroups are likely at risk for greater disease burden due to a higher prevalence of components of the metabolic syndrome, comorbid depression, and low socioeconomic status; however, there is a paucity of research in these populations. Additionally, studies examining the genetic and anatomical basis for HS, as well as the response to HS therapies, are lacking for patients with skin of color. Complicating this issue is the limited access to effective medical care, including dermatologists, for African and Hispanic populations as well as other minority groups. In this review, we identify gaps in the knowledge base, highlight the association between HS and patients with skin of color, and provide direction for much needed research into this condition. (C) 2018 S. Karger AG, Basel
C1 [Lee, Dylan E.] Creighton Univ, Sch Med, Omaha, NE USA.
   [Clark, Ashley K.] Univ Calif Davis, Sch Med, Sacramento, CA 95817 USA.
   [Shi, Vivian Y.] Univ Arizona, Dept Med, Div Dermatol, 1515 N Campbell Ave,POB 245024,Bldg 222,Levy Bldg, Tucson, AZ 85724 USA.
C3 Creighton University; University of California System; University of
   California Davis; University of Arizona
RP Shi, VY (corresponding author), Univ Arizona, Dept Med, Div Dermatol, 1515 N Campbell Ave,POB 245024,Bldg 222,Levy Bldg, Tucson, AZ 85724 USA.
EM vshi@email.arizona.edu
OI Shi, Vivian/0000-0002-7510-9428
CR Alikhan A, 2009, J AM ACAD DERMATOL, V60, P539, DOI 10.1016/j.jaad.2008.11.911
   [Anonymous], 2015, DAN MED J
   Arenbergerova M, 2010, INT J DERMATOL, V49, P1445, DOI 10.1111/j.1365-4632.2010.04638.x
   Blok JL, 2016, BRIT J DERMATOL, V174, P839, DOI 10.1111/bjd.14338
   Cesko E, 2009, EUR J DERMATOL, V19, P490, DOI 10.1684/ejd.2009.0710
   Chen S, 2015, JAMA DERMATOL, V151, P668, DOI 10.1001/jamadermatol.2014.5306
   Cosmatos I, 2013, J AM ACAD DERMATOL, V68, P412, DOI 10.1016/j.jaad.2012.07.027
   Crowley JJ, 2014, BRIT J DERMATOL, V171, P1561, DOI 10.1111/bjd.13122
   Davis SA, 2015, SKIN APPENDAGE DISOR, V1, P65, DOI 10.1159/000431037
   Davis SA, 2012, J DRUGS DERMATOL, V11, P466
   Deckers IE, 2016, J AM ACAD DERMATOL, V75, P755, DOI 10.1016/j.jaad.2016.04.067
   Dunlop DD, 2003, AM J PUBLIC HEALTH, V93, P1945, DOI 10.2105/AJPH.93.11.1945
   Egeberg A, 2016, JAMA DERMATOL, V152, P429, DOI 10.1001/jamadermatol.2015.6264
   Garg A, 2017, J AM ACAD DERMATOL, V77, P118, DOI 10.1016/j.jaad.2017.02.005
   Grant A, 2010, J AM ACAD DERMATOL, V62, P205, DOI 10.1016/j.jaad.2009.06.050
   Homma H, 1926, B JOHNS HOPKINS HOSP, V38, P365
   Ingram JR, 2016, DERMATOL CLIN, V34, P23, DOI 10.1016/j.det.2015.07.002
   Jiao T, 2013, BRIT J DERMATOL, V168, P1141, DOI 10.1111/bjd.12135
   Kamal N, 2016, CLIN GASTROENTEROL H, V14, P71, DOI 10.1016/j.cgh.2015.04.180
   Kim GE, 2014, BRIT J DERMATOL, V171, P338, DOI 10.1111/bjd.13041
   Kim WB, 2016, J CUTAN MED SURG, V20, P52, DOI 10.1177/1203475415602840
   Kimball AB, 2016, NEW ENGL J MED, V375, P422, DOI 10.1056/NEJMoa1504370
   Kimball AB, 2012, ANN INTERN MED, V157, P846, DOI 10.7326/0003-4819-157-12-201212180-00004
   Kohorst JJ, 2015, J AM ACAD DERMATOL, V73, pS27, DOI 10.1016/j.jaad.2015.07.055
   McMillan K, 2014, AM J EPIDEMIOL, V179, P1477, DOI 10.1093/aje/kwu078
   Miller I, 2011, BRIT J DERMATOL, V165, P391, DOI 10.1111/j.1365-2133.2011.10339.x
   Miller IM, 2016, J EUR ACAD DERMATOL, V30, P980, DOI 10.1111/jdv.13522
   Miller IM, 2014, JAMA DERMATOL, V150, P1273, DOI 10.1001/jamadermatol.2014.1165
   Miller LM, 2016, DERMATOL CLIN, V34, P7, DOI 10.1016/j.det.2015.08.002
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   Pan L., 2009, Morbidity and Mortality Weekly Report, V58, P740
   Pelekanou A, 2010, EXP DERMATOL, V19, P538, DOI 10.1111/j.1600-0625.2009.00967.x
   Reeder VJ, 2014, J INVEST DERMATOL, V134, P2842, DOI 10.1038/jid.2014.220
   Santos AC, 2008, BMC PUBLIC HEALTH, V8, DOI 10.1186/1471-2458-8-62
   Shalom G, 2015, BRIT J DERMATOL, V173, P464, DOI 10.1111/bjd.13777
   Shelley, 1960, HUMAN APOCRINE SWEAT, P22
   Taylor SC, 2002, J AM ACAD DERMATOL, V47, P770, DOI 10.1067/mjd.2002.124691
   Thomas C, 2016, AM SURGEON, V82, P362
   Tzanetakou V, 2016, JAMA DERMATOL, V152, P52, DOI 10.1001/jamadermatol.2015.3903
   Vazquez BG, 2013, J INVEST DERMATOL, V133, P97, DOI 10.1038/jid.2012.255
   Vlassova N, 2015, ACTA DERM-VENEREOL, V95, P990, DOI 10.2340/00015555-2176
   Vossen ARJV, 2017, J DERMATOL, V44, P154, DOI 10.1111/1346-8138.13572
   Williams DR, 2007, ARCH GEN PSYCHIAT, V64, P305, DOI 10.1001/archpsyc.64.3.305
   Williams DR, 2016, HEALTH PSYCHOL, V35, P407, DOI 10.1037/hea0000242
   Xu H, 2016, BRIT J DERMATOL, V174, P927, DOI 10.1111/bjd.14268
   Yamamoto N, 2003, CURR BIOL, V13, P333, DOI 10.1016/S0960-9822(03)00081-2
   Yang JQ, 2015, CLIN EXP DERMATOL, V40, P916, DOI 10.1111/ced.12724
NR 47
TC 51
Z9 51
U1 0
U2 3
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1018-8665
EI 1421-9832
J9 DERMATOLOGY
JI Dermatology
PY 2017
VL 233
IS 6
BP 456
EP 461
DI 10.1159/000486741
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology
GA GD4XE
UT WOS:000430505800007
PM 29495009
OA Bronze
DA 2025-06-11
ER

PT J
AU Modi, K
   Singh, I
   Kumar, Y
AF Modi, Krishna
   Singh, Ishbir
   Kumar, Yogesh
TI A Comprehensive Analysis of Artificial Intelligence Techniques for the
   Prediction and Prognosis of Lifestyle Diseases
SO ARCHIVES OF COMPUTATIONAL METHODS IN ENGINEERING
LA English
DT Review
ID METABOLIC SYNDROME; MACHINE; ASTHMA
AB Artificial intelligence is the fastest growing data-driven technology and is currently used in all major fields and reduces the work of humans. Artificial intelligence can analyse extensive data from Electronic Health Records, clinical trials, patient's medical history, X-rays, CT scans and contribute to the healthcare field by explicitly detecting and predicting lifestyle diseases such as Alzheimer, Arthritis, Asthma, Atherosclerosis, COPD, Depression, Obesity, Osteoporosis, Metabolic Syndrome and PCOS. Lifestyle diseases are diseases related to the daily habits or routines of individuals such as smoking, excessive consumption of alcohol, physical inactivity, overeating etc. Common techniques used by AI to diagnose these diseases are Decision Tree, Random Forest, ANN, SVM, Regression, Naive Bayes and deep learning models such as Convolutional Neural Network, Recurrent Neural Network, and Natural Language Processing. A common framework is presented in this paper to carry forward the research to add significant value. This paper presents an extensive overview of the diseases, their symptoms and associated illnesses, risk factors, datasets suitable for developing predictive models, challenges encountered by researchers, and significant contributions made in this area.
C1 [Modi, Krishna] Indus Univ, Indus Inst Technol & Engn, Dept CSE, Ahmadabad 382115, India.
   [Singh, Ishbir] Indus Univ, Indus Inst Technol & Engn, Dept ME, Ahmadabad 382115, India.
   [Kumar, Yogesh] Pandit Deendayal Energy Univ, Sch Technol, Dept CSE, Gandhinagar, Gujarat, India.
C3 Pandit Deendayal Energy University
RP Kumar, Y (corresponding author), Pandit Deendayal Energy Univ, Sch Technol, Dept CSE, Gandhinagar, Gujarat, India.
EM krishnamodi1994@gmail.com; ishbir@rediffmail.com;
   yogesh.arora10744@gmail.com
RI Modi, Krishna/LKK-6786-2024; kumar, yogesh/AAD-8469-2021
OI Modi, Krishna/0000-0001-9840-5919; kumar, yogesh/0000-0002-2879-0441
CR Al Govindasamy Kuhaneswaran, 2021, 2021 5th International Conference on Intelligent Computing and Control Systems (ICICCS), P960, DOI 10.1109/ICICCS51141.2021.9432203
   Alizadeh Behrouz, 2015, Acta Inform Med, V23, P220, DOI 10.5455/aim.2015.23.220-223
   Alroobaea R, 2021, 2021, PREPRINT (Version 1) available at Research Square, DOI [10.21203/RS.3.RS-624520/V1, DOI 10.21203/RS.3.RS-624520/V1]
   Amaral JLM, 2020, MED BIOL ENG COMPUT, V58, P2455, DOI 10.1007/s11517-020-02240-7
   Amaral JLM, 2017, COMPUT METH PROG BIO, V144, P113, DOI 10.1016/j.cmpb.2017.03.023
   Ambale-Venkatesh B, 2017, CIRC RES, V121, P1092, DOI 10.1161/CIRCRESAHA.117.311312
   Anam M, 2021, CMC-COMPUT MATER CON, V67, P89, DOI 10.32604/cmc.2021.013159
   Fernandez-Granero MA, 2015, LECT NOTES COMPUT SC, V9107, P305, DOI 10.1007/978-3-319-18914-7_32
   [Anonymous], 2018, Int J Pure Appl Math
   Ashraf A, 2020, PROCEEDING OF 2020 6TH INTERNATIONAL CONFERENCE ON WIRELESS AND TELEMATICS (ICWT), DOI 10.1109/icwt50448.2020.9243625
   Bharati S., 2020, IEEE REGION 10 SYMP, P1486, DOI [DOI 10.1109/tensymp50017.2020.9230932, 10.1109/TENSYMP50017.2020.9230932]
   Bhardwaj P, 2022, ARCH COMPUT METHOD E, V29, P4379, DOI 10.1007/s11831-022-09737-4
   Bose S, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0247784
   Brisson NM, 2021, ARTHRITIS RHEUMATOL, V73, P1638, DOI 10.1002/art.41735
   Cacheda F, 2019, J MED INTERNET RES, V21, DOI 10.2196/12554
   Candemir S, 2020, COMPUT MED IMAG GRAP, V83, DOI 10.1016/j.compmedimag.2020.101721
   Castellazzi G, 2020, FRONT NEUROINFORM, V14, DOI 10.3389/fninf.2020.00025
   Chaplot N, 2023, ARCH COMPUT METHOD E, V30, P3301, DOI 10.1007/s11831-023-09904-1
   Chatterjee A, 2020, SENSORS-BASEL, V20, DOI 10.3390/s20092734
   Chatzimichail E, 2013, COMPUT MATH METHOD M, V2013, DOI 10.1155/2013/240182
   Choe Eun Kyung, 2018, Genomics & Informatics, V16, pe31
   Cilluffo G, 2022, PEDIAT ALLERG IMM-UK, V33, P34, DOI 10.1111/pai.13624
   Devikanniga D, 2020, INT J INTELL NETW, V1, P43, DOI DOI 10.1016/J.IJIN.2020.05.004
   ERSEVER Y., 500 PERSON GENDER HE
   Feng YH, 2021, INT J MED SCI, V18, P2871, DOI 10.7150/ijms.58191
   Ferdowsy F, 2021, Curr Res Behav Sci, V2, DOI DOI 10.1016/J.CRBEHA.2021.100053
   GBD 2016 Disease and Injury Incidence and Prevalence Collaborators, 2017, Lancet, V390, P1211, DOI 10.1016/S0140-6736(17)32154-2
   Guan YF, 2019, ARTHRITIS RHEUMATOL, V71, P1987, DOI 10.1002/art.41056
   Gupta Mehak, 2022, ACM Trans Comput Healthc, V3, DOI 10.1145/3506719
   Hammond R, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0215571
   Harvey JL, 2019, 2019 IEEE SYMPOSIUM SERIES ON COMPUTATIONAL INTELLIGENCE (IEEE SSCI 2019), P596, DOI 10.1109/SSCI44817.2019.9002692
   Health Institute of Health Research and Development of the Indonesian Ministry of, LAYAN PERM DAT RIS
   Hosseini-Esfahani F, 2021, JMIR PUBLIC HLTH SUR, V7, DOI 10.2196/27304
   Hussain A, 2021, DIAGNOSTICS, V11, DOI 10.3390/diagnostics11050829
   Hussain A, 2021, INT CONF ADV COMMUN, P368, DOI 10.23919/ICACT51234.2021.9370958
   Iliou T, 2014, INT J ARTIF INTELL T, V23, DOI 10.1142/S0218213014500146
   Islam MR, 2018, HEALTH INF SCI SYST, V6, DOI 10.1007/s13755-018-0046-0
   Jindal K., 2018, Recent Findings in Intelligent Computing Techniques: Proceedings of the 5th ICACNI 2017
   Jo T, 2019, FRONT AGING NEUROSCI, V11, DOI 10.3389/fnagi.2019.00220
   Kakudi HA., 2020, MEDRXIV, DOI [10.1101/2020.06.01.20119339, DOI 10.1101/2020.06.01.20119339]
   Kalweit M, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0252289
   Kanna GP, 2023, ARCH COMPUT METHOD E, V30, P3113, DOI 10.1007/s11831-023-09896-y
   Kaur H, 2018, BMC PULM MED, V18, DOI 10.1186/s12890-018-0593-9
   Kaur K, 2023, ARCH COMPUT METHOD E, V30, P3031, DOI 10.1007/s11831-023-09892-2
   Kaur S, 2023, ARCH COMPUT METHOD E, V30, P1863, DOI 10.1007/s11831-022-09853-1
   Kim J, 2022, BMC PUBLIC HEALTH, V22, DOI [10.1186/s12889-022-13131-x, 10.1186/s12906-022-03694-y, 10.1186/s12905-022-01918-4]
   Kim SungKean., 2013, Osteoporosis risk prediction using machine learning and conventional methods
   Kodipalli A, 2021, FRONT PUBLIC HEALTH, V9, DOI 10.3389/fpubh.2021.789569
   Koul A, 2023, ARCH COMPUT METHOD E, V30, P831, DOI 10.1007/s11831-022-09818-4
   Kumar A, 2023, ARCH COMPUT METHOD E, V30, P3867, DOI 10.1007/s11831-023-09936-7
   Kumar Y, 2023, ARCH COMPUT METHOD E, V30, P521, DOI 10.1007/s11831-022-09807-7
   Kumar Y, 2022, J AMB INTEL HUM COMP, DOI 10.1007/s12652-021-03612-z
   Kumar Y, 2022, ARCH COMPUT METHOD E, V29, P2043, DOI 10.1007/s11831-021-09648-w
   Lim HK, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0247330
   Menchón-Lara RM, 2016, APPL SOFT COMPUT, V49, P616, DOI 10.1016/j.asoc.2016.08.055
   More S., 2019, INT J RECENT TECHNOL, DOI [10.35940/ijrte.b1455.0982s1119, DOI 10.35940/IJRTE.B1455.0982S1119]
   Morit K, 2017, INT CONF MACH LEARN, P357
   Munger E, 2021, APL BIOENG, V5, DOI 10.1063/5.0028986
   Orange DE, 2018, ARTHRITIS RHEUMATOL, V70, P690, DOI 10.1002/art.40428
   Parameswari C, 2021, J AMB INTEL HUM COMP, V12, P6701, DOI 10.1007/s12652-020-02294-3
   Park JH, 2020, NPJ DIGIT MED, V3, DOI 10.1038/s41746-020-0256-0
   Park JE, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/8315047
   Priya A, 2020, PROCEDIA COMPUT SCI, V167, P1258, DOI 10.1016/j.procs.2020.03.442
   Rashid J, 2022, FRONT PUBLIC HEALTH, V10, DOI 10.3389/fpubh.2022.860396
   Sarker IH., 2021, SN COMPUT SCI, V2, P160, DOI [DOI 10.1007/S4297902100592X, 10.1007/S42979-021-00592-X/FIGURES/11, DOI 10.1007/S42979-021-00592-X, 10.1007/s42979-021-00592-x]
   Singh B, 2020, LECT NOTES COMPUT SC, V12140, P523, DOI 10.1007/978-3-030-50423-6_39
   Sisodia PS, 2023, ARCH COMPUT METHOD E, V30, P2409, DOI 10.1007/s11831-022-09870-0
   Smets J, 2021, J BONE MINER RES, V36, P833, DOI 10.1002/jbmr.4292
   Srivastava A, 2021, PEERJ COMPUT SCI, DOI 10.7717/peerj-cs.369
   Sudha K, 2020, DEPRESSION DETECTION
   Sumathi M., 2021, IOP Conference Series: Materials Science and Engineering, V1070, DOI 10.1088/1757-899X/1070/1/012062
   Sun G, 2022, 2022 7 INT C SIGN IM, DOI [10.1109/icsip55141.2022.9886372, DOI 10.1109/ICSIP55141.2022.9886372]
   Tahasamadsoltaniheris M., 2013, INT RES J APPL BASIC, V5, P140
   Terrada O., 2020, 1 INT C INN RES APPL, P1, DOI [10.1109/CommNet49926.2020.9199620, DOI 10.1109/IRASET48871.2020.9092082]
   Thakre V, 2020, BIOSCI BIOTECH RES C, V13, P240, DOI 10.21786/bbrc/13.14/56
   Thamrin SA, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.669155
   The Multi Ethnic Study of Atherosclerosis (MESA), US
   Tian JQ, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-020-80312-2
   Tomita K, 2019, ALLERGOL INT, V68, P456, DOI 10.1016/j.alit.2019.04.010
   Uddin MZ, 2022, NEURAL COMPUT APPL, V34, P721, DOI 10.1007/s00521-021-06426-4
   Wi CI, 2017, AM J RESP CRIT CARE, V196, P430, DOI 10.1164/rccm.201610-2006OC
   Xie NN, 2020, BIOMED RES INT, V2020, DOI 10.1155/2020/2613091
   Yamamoto N, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10111534
   Yang HZ, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-06235-2
   Zhang H, 2021, RISK MANAG HEALTHC P, V14, P4361, DOI 10.2147/RMHP.S328180
NR 85
TC 12
Z9 12
U1 4
U2 27
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1134-3060
EI 1886-1784
J9 ARCH COMPUT METHOD E
JI Arch. Comput. Method Eng.
PD NOV
PY 2023
VL 30
IS 8
BP 4733
EP 4756
DI 10.1007/s11831-023-09957-2
EA JUN 2023
PG 24
WC Computer Science, Interdisciplinary Applications; Engineering,
   Multidisciplinary; Mathematics, Interdisciplinary Applications
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Computer Science; Engineering; Mathematics
GA U7EJ1
UT WOS:001016161300001
DA 2025-06-11
ER

PT J
AU Maksimovic, M
   Vlajinac, H
   Radak, D
   Marinkovic, J
   Jorga, J
AF Maksimovic, Milos
   Vlajinac, Hristina
   Radak, Djordje
   Marinkovic, Jelena
   Jorga, Jagoda
TI Relationship Between High-Sensitivity C-Reactive Protein and Risk
   Factors in Patients With Peripheral Arterial Disease-A Cross-Sectional
   Study
SO ANGIOLOGY
LA English
DT Article
DE high-sensitivity C-reactive protein; peripheral arterial disease; risk
   factors
ID CARDIOVASCULAR-DISEASE; URIC-ACID; METABOLIC SYNDROME;
   MYOCARDIAL-INFARCTION; INFLAMMATORY MARKERS; INSULIN-RESISTANCE;
   VASCULAR-DISEASE; ATHEROSCLEROSIS; WOMEN; ASSOCIATION
AB We investigated whether patients with peripheral arterial disease (PAD) with various serum levels of high-sensitivity C-reactive protein (hsCRP) differ in the frequency of atherosclerotic risk factors. Among 388 patients, hsCRP levels were (1) low, <1 mg/L, in 41 (10.6%) participants; (2) medium, from 1 to 3 mg/L, in 152 (39.2%) participants, and (3) high, >3 mg/L, in 195 (50.2%) individuals. According to multivariate logistic regression analysis, in comparison with patients with hsCRP level <= 3.0 mg/L, those with higher hsCRP levels had more frequently a severe form of PAD(gangrene, P ranged from. 045 to <.001; ankle-brachial index <=.40, P = .059) and had more frequently some of atherosclerotic risk factors (metabolic syndrome, P = .007; hypertension, P = .013; abdominal obesity, P = .007; high levels of uric acid, P = .022; high level of fibrinogen, P <.001; and depression, P = .015).
C1 [Maksimovic, Milos; Jorga, Jagoda] Univ Belgrade, Inst Hyg & Med Ecol, Fac Med, Belgrade 11001, Serbia.
   [Vlajinac, Hristina] Univ Belgrade, Inst Epidemiol, Fac Med, Belgrade 11001, Serbia.
   [Radak, Djordje] Univ Belgrade, Dept Vasc Surg, Fac Med, Dedinje Cardiovasc Inst, Belgrade 11001, Serbia.
   [Marinkovic, Jelena] Univ Belgrade, Inst Med Stat & Informat, Fac Med, Belgrade 11001, Serbia.
C3 University of Belgrade; University of Belgrade; University of Belgrade;
   University of Belgrade
RP Maksimovic, M (corresponding author), Univ Belgrade, Inst Hyg & Med Ecol, Fac Med, Belgrade 11001, Serbia.
EM milos.maksimovic@mfub.bg.ac.rs
RI Maksimović, Miloš/ABF-7728-2021; jorga, jagoda/I-1383-2012
OI Vlajinac, Hristina/0000-0002-8239-2989; Maksimovic,
   Milos/0000-0002-6346-3171
FU Ministry of Education and Science Serbia [III41002]
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: supported by
   Ministry of Education and Science Serbia, through contract no. III41002
   (2011-2014).
CR Abdellaoui A, 2007, EUR J VASC ENDOVASC, V34, P18, DOI 10.1016/j.ejvs.2006.10.040
   [Anonymous], 1998, OB PREV MAN GLOB EP
   Aronow WS, 2004, J GERONTOL A-BIOL, V59, P172
   Athyros VG, 2007, NEPHROL DIAL TRANSPL, V22, P118, DOI 10.1093/ndt/gfl538
   BAECKE JAH, 1982, AM J CLIN NUTR, V36, P936
   BALLOU SP, 1992, ADV INTERNAL MED, V37, P313
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   BECK AT, 1988, CLIN PSYCHOL REV, V8, P77, DOI 10.1016/0272-7358(88)90050-5
   Beckman JA, 2005, AM J CARDIOL, V96, P1374, DOI 10.1016/j.amjcard.2005.07.041
   Cao JJ, 2003, CIRCULATION, V108, P166, DOI 10.1161/01.CIR.0000079160.07364.6A
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   Criqui MH., 1985, Circulation, V71, P510515
   Daskalopoulou SS, 2008, CIRC J, V72, P441, DOI 10.1253/circj.72.441
   Doweik L, 2003, EUR J VASC ENDOVASC, V26, P381, DOI 10.1016/S1078-5884(03)00340-X
   DURNIN JVGA, 1974, BRIT J NUTR, V32, P77, DOI 10.1079/BJN19740060
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Gagliardi ACM, 2009, ATHEROSCLEROSIS, V202, P11, DOI 10.1016/j.atherosclerosis.2008.05.022
   Greenland P, 2000, Circulation, V101, pE16
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Hankey GJ, 2006, JAMA-J AM MED ASSOC, V295, P547, DOI 10.1001/jama.295.5.547
   Hozawa A, 2004, HYPERTENS RES, V27, P955, DOI 10.1291/hypres.27.955
   Johnson BD, 2004, CIRCULATION, V109, P726, DOI 10.1161/01.CIR.0000115516.54550.B1
   Kanellis J, 2005, SEMIN NEPHROL, V25, P39, DOI 10.1016/j.semnephrol.2004.09.007
   Koenig W, 2003, THROMB HAEMOSTASIS, V89, P601
   Lemieux I, 2001, ARTERIOSCL THROM VAS, V21, P961, DOI 10.1161/01.ATV.21.6.961
   Lin S.D., 2006, J. Chin. Med. Assoc., V69, P512, DOI [10.1016/S1726-4901(09)70320-X, DOI 10.1016/S1726-4901(09)70320-X, 10.1016/s1726-4901(09)70320-x]
   Liu ZM, 2011, MATURITAS, V70, P176, DOI 10.1016/j.maturitas.2011.07.007
   Marso SP, 2006, J AM COLL CARDIOL, V47, P921, DOI 10.1016/j.jacc.2005.09.065
   McDermott MM, 2005, AM HEART J, V150, P276, DOI 10.1016/j.ahj.2004.09.032
   McDermott MM, 2004, J AM GERIATR SOC, V52, P1888, DOI 10.1111/j.1532-5415.2004.52514.x
   McDermott MM, 2003, AM J CARDIOL, V92, P194, DOI 10.1016/S0002-9149(03)00537-X
   Mertens I, 2002, Obes Rev, V3, P85, DOI 10.1046/j.1467-789X.2002.00056.x
   Meru AV, 2006, ATHEROSCLEROSIS, V187, P221, DOI 10.1016/j.atherosclerosis.2005.11.027
   Nakou ES, 2008, CURR VASC PHARMACOL, V6, P258, DOI 10.2174/157016108785909733
   Owens CD, 2007, J VASC SURG, V45, P2, DOI 10.1016/j.jvs.2006.08.048
   Paraskevas KI, 2009, ANGIOLOGY, V60, P8, DOI 10.1177/0003319708330707
   Pearson TA, 2003, CIRCULATION, V107, P499, DOI 10.1161/01.CIR.0000052939.59093.45
   Pitsavos C, 2007, ANGIOLOGY, V58, P225, DOI 10.1177/0003319707300014
   Ridker PM, 1998, CIRCULATION, V97, P425
   Ridker PM, 2000, CIRCULATION, V101, P1767, DOI 10.1161/01.CIR.101.15.1767
   Ridker PM, 1997, NEW ENGL J MED, V336, P973, DOI 10.1056/NEJM199704033361401
   Ridker PM, 2002, NEW ENGL J MED, V347, P1557, DOI 10.1056/NEJMoa021993
   Ridker PM, 2001, JAMA-J AM MED ASSOC, V285, P2481, DOI 10.1001/jama.285.19.2481
   Ridker PM, 2000, NEW ENGL J MED, V342, P836, DOI 10.1056/NEJM200003233421202
   Rossi E, 2002, CIRCULATION, V105, P800, DOI 10.1161/hc0702.104126
   Santos AC, 2005, INT J OBESITY, V29, P1452, DOI 10.1038/sj.ijo.0803035
   Schillinger M, 2004, EUR HEART J, V25, P742, DOI 10.1016/j.ehj.2004.02.012
   Shankar A, 2007, AM HEART J, V154, P495, DOI 10.1016/j.ahj.2007.04.060
   Silvestro A, 2003, VASC MED, V8, P225, DOI 10.1191/1358863x03vm503oa
   Tennent GA, 2005, P NATL ACAD SCI USA, V102, P8309
   TILLETT WILLIAM S., 1930, JOUR EXP MED, V52, P561, DOI 10.1084/jem.52.4.561
   Tzoulaki I, 2005, CIRCULATION, V112, P976, DOI 10.1161/CIRCULATIONAHA.104.513085
   Vainas T, 2005, J VASC SURG, V42, P243, DOI 10.1016/j.jvs.2005.03.060
   Vainas T, 2003, CIRCULATION, V107, P1103, DOI 10.1161/01.CIR.0000059938.95404.92
   Vu JD, 2005, AM J CARDIOL, V96, P655, DOI 10.1016/j.amjcard.2005.04.038
   Wattanakit K, 2005, ATHEROSCLEROSIS, V180, P389, DOI 10.1016/j.atherosclerosis.2004.11.024
NR 56
TC 8
Z9 9
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD APR
PY 2013
VL 64
IS 3
BP 230
EP 236
DI 10.1177/0003319712440303
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 118EQ
UT WOS:000317006400011
PM 22499952
DA 2025-06-11
ER

PT J
AU Mast, BT
   Miles, T
   Penninx, BW
   Yaffe, K
   Rosano, C
   Satterfield, S
   Ayonayon, HN
   Harris, T
   Simonsick, EM
AF Mast, Benjamin T.
   Miles, Toni
   Penninx, Brenda W.
   Yaffe, Kristine
   Rosano, Caterina
   Satterfield, Suzanne
   Ayonayon, Hilsa N.
   Harris, Tamara
   Simonsick, Eleanor M.
TI Vascular disease and future risk of depressive symptomatology in older
   adults: Findings from the Health, Aging, and Body Composition study
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE cerebrovascular disease; geriatric depression; vascular depression
ID LATE-LIFE DEPRESSION; WHITE-MATTER HYPERINTENSITIES; SCALE CES-D;
   CEREBROVASCULAR-DISEASE; CRITERION VALIDITY; MAJOR DEPRESSION; SYMPTOMS;
   ATHEROSCLEROSIS; DYSFUNCTION; MORTALITY
AB Background: The vascular depression hypothesis suggests that age-related vascular diseases and risk factors contribute to late-life depression. Although neuroimaging studies provide evidence for an association between depression and severity of vascular lesions in the brain, studies of depression and indicators of vascular risk have been less consistent.
   Methods: We examined 1796 elders ages 70-79 from the Health, Aging and Body Composition study without depression at baseline and examined the association between prevalent vascular disease and related conditions at baseline and 2-year incidence of elevated depressive symptoms, defined as a score > 8 on the 10-item Center for Epidemiologic Studies Depression (CES-D) scale.
   Results: After adjustment for demographic data and physical and cognitive functioning, several vascular conditions remained associated with increased risk of depressive symptomatology including metabolic syndrome and its components (low high-density lipoprotein cholesterol and high fasting glucose), coronary heart disease, a positive Rose questionnaire for angina, and high hemoglobin a1c. Cumulative vascular risk based upon a composite of 10 vascular diseases and risk factors was independently associated with incident elevated depression at 2-year follow-up after controlling for demographic data, physical and cognitive functioning, and selected comorbid medical conditions.
   Conclusions: These results provide support for the vascular depression hypothesis in demonstrating an association between vascular conditions and risk factors and subsequent risk of depressive symptomatology. Older adults with vascular conditions and risk factors require close monitoring of depressive symptoms.
C1 [Mast, Benjamin T.; Miles, Toni] Univ Louisville, Louisville, KY 40292 USA.
   [Penninx, Brenda W.] VU Univ Med, Amsterdam, Netherlands.
   [Yaffe, Kristine; Ayonayon, Hilsa N.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Rosano, Caterina] Univ Pittsburgh, Pittsburgh, PA 15260 USA.
   [Satterfield, Suzanne] Univ Tennessee, Memphis, TN USA.
   [Harris, Tamara] NIA, Lab Epidemol Demog & Biometry, Bethesda, MD 20892 USA.
   [Simonsick, Eleanor M.] NIA, Clin Res Branch, Baltimore, MD 21224 USA.
   [Simonsick, Eleanor M.] Johns Hopkins Sch Med, Baltimore, MD USA.
C3 University of Louisville; Vrije Universiteit Amsterdam; VU UNIVERSITY
   MEDICAL CENTER; University of California System; University of
   California San Francisco; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh; University of Tennessee
   System; University of Tennessee Health Science Center; National
   Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA);
   National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); Johns Hopkins University; Johns Hopkins Medicine
RP Mast, BT (corresponding author), Univ Louisville, 317 Life Sci Bldg, Louisville, KY 40292 USA.
EM b.mast@louisville.edu
RI Yaffe, Kristine/LLL-8209-2024; Penninx, Brenda/S-7627-2017; Simonsick,
   Eleanor/W-6864-2019; Miles, Toni/ACM-0703-2022
OI Miles, Toni/0000-0003-0823-2319; Rosano, Caterina/0000-0002-0909-1506;
   Rosano, Caterina/0000-0002-4271-6010
FU NHLBI NIH HHS [R01-HL972972] Funding Source: Medline; NIA NIH HHS
   [N01-AG-6-2103, N01-AG-6-2106, N01-AG-6-2101] Funding Source: Medline;
   Intramural NIH HHS Funding Source: Medline
CR Alexopoulos GS, 1997, ARCH GEN PSYCHIAT, V54, P915
   Alexopoulos GS, 2003, J AM GERIATR SOC, V51, P1178, DOI 10.1046/j.1532-5415.2003.51373.x
   Alexopoulos GS, 2002, AM J GERIAT PSYCHIAT, V10, P687, DOI 10.1176/appi.ajgp.10.6.687
   ANDRESEN EM, 1994, AM J PREV MED, V10, P77, DOI 10.1016/S0749-3797(18)30622-6
   [Anonymous], 2005, DIABETES CARE, V28, pS4
   Baldwin RC, 2005, INT J GERIATR PSYCH, V20, P1, DOI 10.1002/gps.1255
   Baldwin RC, 2002, BRIT J PSYCHIAT, V180, P157, DOI 10.1192/bjp.180.2.157
   Beekman ATF, 1997, PSYCHOL MED, V27, P231, DOI 10.1017/S0033291796003510
   Blazer DG, 2003, J GERONTOL A-BIOL, V58, P249
   Campbell JJ, 2001, J NEUROPSYCH CLIN N, V13, P261, DOI 10.1176/appi.neuropsych.13.2.261
   CHARLSON ME, 1987, J CHRON DIS, V40, P373, DOI 10.1016/0021-9681(87)90171-8
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   DEYO RA, 1992, J CLIN EPIDEMIOL, V45, P613, DOI 10.1016/0895-4356(92)90133-8
   FOLSTEIN MF, 1975, J PSYCHIAT RES, V12, P189, DOI 10.1016/0022-3956(75)90026-6
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Greenwald BS, 1998, STROKE, V29, P613, DOI 10.1161/01.STR.29.3.613
   Hickie I, 2003, AUST NZ J PSYCHIAT, V37, P62, DOI 10.1046/j.1440-1614.2003.01105.x
   Holley C, 2006, AM J GERIAT PSYCHIAT, V14, P84, DOI 10.1097/01.JGP.0000192504.48810.cb
   Irwin M, 1999, ARCH INTERN MED, V159, P1701, DOI 10.1001/archinte.159.15.1701
   Jones DJ, 2003, ARCH GEN PSYCHIAT, V60, P153, DOI 10.1001/archpsyc.60.2.153
   Jorm AF, 2001, AUST NZ J PSYCHIAT, V35, P776, DOI 10.1046/j.1440-1614.2001.00967.x
   Jorm AF, 2000, GERONTOLOGY, V46, P219, DOI 10.1159/000022163
   Kalaria RN, 2003, INT PSYCHOGERIATR, V15, P47, DOI 10.1017/S1041610203008950
   Kales HC, 2005, AM J GERIAT PSYCHIAT, V13, P88, DOI 10.1176/appi.ajgp.13.2.88
   Katz IR, 2004, AM J GERIAT PSYCHIAT, V12, P1
   Knol MJ, 2006, DIABETOLOGIA, V49, P837, DOI 10.1007/s00125-006-0159-x
   Krishnan KRR, 1997, AM J PSYCHIAT, V154, P497
   Lewinsohn PM, 1997, PSYCHOL AGING, V12, P277, DOI 10.1037/0882-7974.12.2.277
   Lyness JM, 1999, AM J GERIAT PSYCHIAT, V7, P252, DOI 10.1097/00019442-199908000-00010
   Lyness JM, 2000, AM J PSYCHIAT, V157, P1499, DOI 10.1176/appi.ajp.157.9.1499
   Lyness JM, 2006, ANN INTERN MED, V144, P496, DOI 10.7326/0003-4819-144-7-200604040-00008
   Lyness JM, 1998, AM J GERIAT PSYCHIAT, V6, P5
   Mast BT, 2005, AGING MENT HEALTH, V9, P146, DOI 10.1080/13607860412331336832
   Mast BT, 2004, AM J GERIAT PSYCHIAT, V12, P84, DOI 10.1176/appi.ajgp.12.1.84
   Mast BT, 2004, AM J GERIAT PSYCHIAT, V12, P93, DOI 10.1176/appi.ajgp.12.1.93
   Moore CA, 1996, REHABIL PSYCHOL, V41, P115
   Nebes RD, 2001, AM J PSYCHIAT, V158, P878, DOI 10.1176/appi.ajp.158.987.878
   Newman AB, 1999, ARTERIOSCL THROM VAS, V19, P538, DOI 10.1161/01.ATV.19.3.538
   O'Brien JT, 2003, LANCET NEUROL, V2, P89, DOI 10.1016/S1474-4422(03)00305-3
   O'Brien JT, 2003, INT J GERIATR PSYCH, V18, P656, DOI 10.1002/gps.848
   OBrien J, 1996, BRIT J PSYCHIAT, V168, P477, DOI 10.1192/bjp.168.4.477
   Penninx BWJH, 2001, ARCH GEN PSYCHIAT, V58, P221, DOI 10.1001/archpsyc.58.3.221
   Penninx BWJH, 2003, BIOL PSYCHIAT, V54, P566, DOI 10.1016/S0006-3223(02)01811-5
   Pugh KG, 2002, NEUROBIOL AGING, V23, P421, DOI 10.1016/S0197-4580(01)00319-0
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Regan C, 2006, NEUROLOGY, V67, P1357, DOI 10.1212/01.wnl.0000240129.46080.53
   Rohlfing CL, 2002, DIABETES CARE, V25, P275, DOI 10.2337/diacare.25.2.275
   ROSE G, 1977, BRIT J PREV SOC MED, V31, P42
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Sanders MLS, 2006, AM J GERIAT PSYCHIAT, V14, P145, DOI 10.1097/01.JGP.0000192482.27931.1e
   Simonsick EM, 2001, J GERONTOL A-BIOL, V56, pM644, DOI 10.1093/gerona/56.10.M644
   Steffens DC, 2006, ARCH GEN PSYCHIAT, V63, P130, DOI 10.1001/archpsyc.63.2.130
   Steffens DC, 1999, STROKE, V30, P2159, DOI 10.1161/01.STR.30.10.2159
   Steffens DC, 2002, STROKE, V33, P1636, DOI 10.1161/01.STR.0000018405.59799.D5
   Thomas AJ, 2000, AM J PSYCHIAT, V157, P1682, DOI 10.1176/appi.ajp.157.10.1682
   Thomas AJ, 2005, AM J PSYCHIAT, V162, P175, DOI 10.1176/appi.ajp.162.1.175
   Thomas AJ, 2002, ARCH GEN PSYCHIAT, V59, P785, DOI 10.1001/archpsyc.59.9.785
   Thomas AJ, 2001, J NEUROL NEUROSUR PS, V70, P83, DOI 10.1136/jnnp.70.1.83
   Tiemeier H, 2004, ARCH GEN PSYCHIAT, V61, P369, DOI 10.1001/archpsyc.61.4.369
   Yochim BP, 2006, PSYCHOL AGING, V21, P186, DOI 10.1037/0882-7974.21.1.186
   1998, OBES RES S, V6
NR 61
TC 56
Z9 69
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD AUG 15
PY 2008
VL 64
IS 4
BP 320
EP 326
DI 10.1016/j.biopsych.2008.01.025
PG 7
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 336IJ
UT WOS:000258357200009
PM 18367153
DA 2025-06-11
ER

PT J
AU Paparella, R
   Panvino, F
   Tarani, F
   D'Agostino, B
   Leonardi, L
   Ferraguti, G
   Venditti, S
   Colloridi, F
   Pucarelli, I
   Tarani, L
   Fiore, M
AF Paparella, Roberto
   Panvino, Fabiola
   Tarani, Francesca
   D'Agostino, Benedetto
   Leonardi, Lucia
   Ferraguti, Giampiero
   Venditti, Sabrina
   Colloridi, Fiorenza
   Pucarelli, Ida
   Tarani, Luigi
   Fiore, Marco
TI An Overview of Oxidative Stress in Sex Chromosome Aneuploidies in
   Pediatric Populations
SO ANTIOXIDANTS
LA English
DT Review
DE sex chromosome aneuploidies; antioxidants; oxidative stress; pediatrics;
   Klinefelter syndrome; Turner syndrome
ID TURNER SYNDROME; MELATONIN SECRETION; METABOLIC SYNDROME; LINKED
   INHIBITOR; BODY-COMPOSITION; POTENTIAL ROLE; ANTIOXIDANT; INFLAMMATION;
   MECHANISMS; DISEASE
AB Background: Oxidative stress, defined as an imbalance between reactive oxygen species and antioxidant defenses, plays a pivotal role in the pathogenesis of sex chromosome aneuploidies (SCAs), such as Turner syndrome (TS) and Klinefelter syndrome (KS). Pediatric patients with SCAs are particularly susceptible due to hormonal deficiencies, metabolic disturbances, and systemic complications. Methods: A comprehensive literature search was conducted in November 2024 using PubMed, Scopus, and Web of Science. Keywords included "antioxidants", "oxidative stress", "pediatrics", "Turner syndrome", "Klinefelter syndrome", and "sex chromosome aneuploidies". English-language articles were included without publication year restrictions. Relevant data on oxidative stress mechanisms and antioxidant interventions were systematically extracted. Results: The relationship between oxidative stress and SCAs can be described as bidirectional, where oxidative stress both contributes to and is exacerbated by aneuploidies. TS is marked by estrogen deficiency, cardiovascular anomalies, and metabolic dysfunction, all linked to heightened oxidative stress. KS is associated with hypogonadism, metabolic syndrome, and neurocognitive challenges, further exacerbated by oxidative damage. The aneuploid condition predisposes to increased oxidative stress in other SCAs, including 47,XXX and 47,XYY, as well as in high-grade aneuploidies. Emerging evidence highlights the therapeutic potential of antioxidants, including vitamin C, vitamin E, glutathione precursors, polyphenols, and melatonin. These interventions, when combined with hormonal therapies such as estrogen replacement in TS or testosterone replacement in KS, demonstrate synergistic effects in restoring redox balance and mitigating systemic complications. Conclusions: Oxidative stress significantly impacts the progression of SCAs in pediatric populations, amplifying risks across metabolic, cardiovascular, and neurocognitive domains. Early, tailored antioxidant strategies, integrated with syndrome-specific hormonal therapies, could reduce long-term complications and improve patient outcomes. Future research should focus on standardizing protocols to optimize these interventions for pediatric patients with SCAs.
C1 [Paparella, Roberto; Tarani, Francesca; D'Agostino, Benedetto; Leonardi, Lucia; Colloridi, Fiorenza; Pucarelli, Ida; Tarani, Luigi] Sapienza Univ Rome, Dept Maternal Infantile & Urol Sci, I-00185 Rome, Italy.
   [Panvino, Fabiola] Sapienza Univ Rome, Dept Human Neurosci, Sect Child & Adolescent Neuropsychiat, I-00185 Rome, Italy.
   [Ferraguti, Giampiero] Sapienza Univ Rome, Dept Expt Med, I-00185 Rome, Italy.
   [Venditti, Sabrina] Sapienza Univ Rome, Dept Biol & Biotechnol Charles Darwin, I-00185 Rome, Italy.
   [Fiore, Marco] Sapienza Univ Rome, Inst Biochem & Cell Biol IBBC CNR, Dept Sensory Organs, I-00185 Rome, Italy.
C3 Sapienza University Rome; Sapienza University Rome; Sapienza University
   Rome; Sapienza University Rome; Sapienza University Rome; Consiglio
   Nazionale delle Ricerche (CNR); Istituto di Biochimica e Biologia
   Cellulare (IBBC-CNR)
RP Tarani, L (corresponding author), Sapienza Univ Rome, Dept Maternal Infantile & Urol Sci, I-00185 Rome, Italy.; Fiore, M (corresponding author), Sapienza Univ Rome, Inst Biochem & Cell Biol IBBC CNR, Dept Sensory Organs, I-00185 Rome, Italy.
EM roberto.paparella@uniroma1.it; fabiola.panvino@uniroma1.it;
   francesca.tarani@uniroma1.it; benedetto.dagostino@uniroma1.it;
   lucia.leonardi@uniroma1.it; giampiero.ferraguti@uniroma1.it;
   sabrina.venditti@uniroma1.it; fiorenza.colloridi@uniroma1.it;
   ida.pucarelli@uniroma1.it; luigi.tarani@uniroma1.it; marco.fiore@cnr.it
RI Tarani, Francesca/IQU-9693-2023; Fiore, Marco/AAA-1706-2021; Paparella,
   Roberto/IUN-0187-2023
CR Aguirre R, 2008, PHARMACOL THERAPEUT, V119, P96, DOI 10.1016/j.pharmthera.2008.05.002
   Aitken RJ, 2001, REPRODUCTION, V122, P497, DOI 10.1530/rep.0.1220497
   Aitken RJ, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.581838
   Aksglaede L, 2008, ARCH DIS CHILD, V93, P30, DOI 10.1136/adc.2007.120675
   Andrés CMC, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24031841
   Andriani GA, 2017, MECH AGEING DEV, V161, P19, DOI 10.1016/j.mad.2016.03.007
   [Anonymous], 2000, Dietary reference intakes: Applications in dietary assessment
   Arancibia-Riveros C, 2024, CLIN NUTR, V43, P1865, DOI 10.1016/j.clnu.2024.06.023
   ATTANASIO A, 1984, PEDIATR RES, V18, P1227, DOI 10.1203/00006450-198411000-00157
   Attri P, 2015, SCI REP-UK, V5, DOI 10.1038/srep09332
   Banan A, 2000, J PHARMACOL EXP THER, V294, P997
   Baraibar MA, 2012, PROG MOL BIOL TRANSL, V109, P249, DOI 10.1016/B978-0-12-397863-9.00007-9
   Berglund A, 2020, GENET MED, V22, P1542, DOI 10.1038/s41436-020-0837-y
   Berglund A, 2019, ORPHANET J RARE DIS, V14, DOI 10.1186/s13023-018-0976-2
   Biradar VS, 2021, IN VITRO CELL DEV-AN, V57, P661, DOI 10.1007/s11626-021-00604-3
   Bonomi M, 2017, J ENDOCRINOL INVEST, V40, P123, DOI 10.1007/s40618-016-0541-6
   Borrás C, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/8101615
   Borrás C, 2006, FASEB J, V20, P2136, DOI 10.1096/fj.05-5522fje
   Caglayan S, 2001, J CLIN ENDOCR METAB, V86, P738, DOI 10.1210/jc.86.2.738
   Calcaterra V, 2014, METAB SYNDR RELAT D, V12, P159, DOI 10.1089/met.2013.0075
   Carito V, 2017, NUTRITION, V33, P65, DOI 10.1016/j.nut.2016.08.014
   Carlomagno F, 2023, J CLIN ENDOCR METAB, V108, pE1329, DOI 10.1210/clinem/dgad281
   Carr AC, 2017, NUTRIENTS, V9, DOI 10.3390/nu9111211
   Chaudhary P, 2023, FRONT CHEM, V11, DOI 10.3389/fchem.2023.1158198
   Chen G, 2023, J CELL SCI, V136, DOI 10.1242/jcs.260688
   Chen JQ, 2004, ANN NY ACAD SCI, V1028, P258, DOI 10.1196/annals.1322.030
   Chen YC, 2012, J FORMOS MED ASSOC, V111, P57, DOI 10.1016/j.jfma.2011.11.024
   Chitimus DM, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10091211
   Cimmino TP, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24032086
   Clémençon B, 2013, MOL ASPECTS MED, V34, P485, DOI 10.1016/j.mam.2012.05.006
   Couto N, 2016, FREE RADICAL BIO MED, V95, P27, DOI 10.1016/j.freeradbiomed.2016.02.028
   Cruz-Topete D, 2020, REDOX BIOL, V31, DOI 10.1016/j.redox.2020.101490
   Demirci-Çekiç S, 2022, J PHARMACEUT BIOMED, V209, DOI 10.1016/j.jpba.2021.114477
   Di Mascio P, 2019, CHEM REV, V119, P2043, DOI 10.1021/acs.chemrev.8b00554
   Dimauro I, 2016, FREE RADICAL BIO MED, V98, P46, DOI 10.1016/j.freeradbiomed.2016.03.028
   Dulac Y, 2008, ARCH CARDIOVASC DIS, V101, P485, DOI 10.1016/j.acvd.2008.05.007
   Edmondson DE, 2018, SUBCELL BIOCHEM, V87, P117, DOI 10.1007/978-981-10-7757-9_5
   Soto ME, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/760694
   Elliot SJ, 2022, MOL THER, V30, P947, DOI 10.1016/j.ymthe.2021.06.020
   Enns GM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100001
   Eskenazi B, 2005, HUM REPROD, V20, P1006, DOI 10.1093/humrep/deh725
   Felty Q, 2005, BIOCHEMISTRY-US, V44, P6900, DOI 10.1021/bi047629p
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Ferraguti G, 2023, NEUROSCI BIOBEHAV R, V145, DOI 10.1016/j.neubiorev.2022.105015
   Ferrer-Sueta G, 2018, CHEM REV, V118, P462, DOI 10.1021/acs.chemrev.7b00568
   Fiedor J, 2014, NUTRIENTS, V6, P466, DOI 10.3390/nu6020466
   Fiore M, 2022, CAN J PHYSIOL PHARM, V100, P151, DOI 10.1139/cjpp-2021-0457
   Fiore M, 2020, J FUNCT FOODS, V71, DOI 10.1016/j.jff.2020.104012
   Fleming AM, 2022, INT J RADIAT BIOL, V98, P452, DOI 10.1080/09553002.2021.2003464
   Forman HJ, 2010, BIOCHEMISTRY-US, V49, P835, DOI 10.1021/bi9020378
   Galbusera C, 2006, BIOCHEM PHARMACOL, V71, P1747, DOI 10.1016/j.bcp.2006.02.008
   Gantenbein KV, 2021, NUTRIENTS, V13, DOI 10.3390/nu13061951
   Garofoli F, 2024, J PINEAL RES, V76, DOI 10.1111/jpi.12932
   Gaschler MM, 2017, BIOCHEM BIOPH RES CO, V482, P419, DOI 10.1016/j.bbrc.2016.10.086
   Ghosh D, 2009, MOL NUTR FOOD RES, V53, P322, DOI 10.1002/mnfr.200800182
   Gravholt CH, 2019, NAT REV ENDOCRINOL, V15, P601, DOI 10.1038/s41574-019-0224-4
   Gravholt CH, 2018, ENDOCR REV, V39, P389, DOI 10.1210/er.2017-00212
   Gravholt CH, 2017, EUR J ENDOCRINOL, V177, pG1, DOI 10.1530/EJE-17-0430
   Gravholt CH, 2011, ACTA PAEDIATR, V100, P871, DOI 10.1111/j.1651-2227.2011.02233.x
   Grinberg L, 2005, FREE RADICAL BIO MED, V38, P136, DOI 10.1016/j.freeradbiomed.2004.09.025
   Hannah-Shmouni F., 2017, Can. J. Diabetes, V41, pS30, DOI [10.1016/j.jcjd.2017.08.090, DOI 10.1016/J.JCJD.2017.08.090]
   Hassold TJ, 2021, PRENATAL DIAG, V41, P584, DOI 10.1002/pd.5910
   Haymana C, 2018, ENDOCR METAB IMMUNE, V18, P401, DOI 10.2174/1871530318666180220114322
   He ZF, 2023, ENVIRON POLLUT, V338, DOI 10.1016/j.envpol.2023.122563
   Petek TH, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11050894
   Hrycay E.G., 2015, Adv. Pharmacol, V74, P35, DOI DOI 10.1016/BS.APHA.2015.03.003
   Huang Y, 2019, FREE RADICAL BIO MED, V137, P181, DOI 10.1016/j.freeradbiomed.2019.04.037
   Ildarabadi A, 2024, REV NEUROSCIENCE, V35, P473, DOI 10.1515/revneuro-2023-0128
   Ingold I, 2018, CELL, V172, P409, DOI 10.1016/j.cell.2017.11.048
   Izigov N, 2011, FREE RADICAL BIO MED, V50, P1131, DOI 10.1016/j.freeradbiomed.2011.01.028
   Jevalikar GS, 2015, J PEDIATR ENDOCR MET, V28, P1203, DOI 10.1515/jpem-2014-0208
   Jiang Q, 2014, FREE RADICAL BIO MED, V72, P76, DOI 10.1016/j.freeradbiomed.2014.03.035
   Juan CA, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22094642
   Karbasi S, 2023, NUTR J, V22, DOI 10.1186/s12937-023-00841-0
   Kasai S, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10020320
   Kaulmann A, 2014, NUTR RES, V34, P907, DOI 10.1016/j.nutres.2014.07.010
   Kehrer JP, 2000, TOXICOLOGY, V149, P43, DOI 10.1016/S0300-483X(00)00231-6
   Kozel BA, 2014, HYPERTENSION, V63, P74, DOI 10.1161/HYPERTENSIONAHA.113.02087
   Kozel BA, 2011, J BIOL CHEM, V286, P44926, DOI 10.1074/jbc.M111.274779
   Krinsky Norman I., 2005, Molecular Aspects of Medicine, V26, P459
   Kumar M, 2012, INDIAN J MED RES, V135, P92
   Landrum JT, 2001, ARCH BIOCHEM BIOPHYS, V385, P28, DOI 10.1006/abbi.2000.2171
   Lanfranco F, 2004, LANCET, V364, P273, DOI 10.1016/S0140-6736(04)16678-6
   Lau Francis C, 2007, Subcell Biochem, V42, P299
   Lavoie JC, 2018, ANTIOXIDANTS-BASEL, V7, DOI 10.3390/antiox7040049
   Lee SKM, 2023, SLEEP MED REV, V70, DOI 10.1016/j.smrv.2023.101808
   Leisegang K, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10111834
   Leser M, 2019, PROTEIN PEPTIDE LETT, V26, P61, DOI 10.2174/0929866526666181212164812
   Li P, 2018, ENDOCR CONNECT, V7, P573, DOI 10.1530/EC-18-0115
   Liu S, 2023, P NATL ACAD SCI USA, V120, DOI 10.1073/pnas.2218478120
   LORDASANCHEZ I, 1992, HUM HERED, V42, P193, DOI 10.1159/000154066
   Lott IT, 2005, NEUROBIOL AGING, V26, P383, DOI 10.1016/j.neurobiolaging.2004.08.005
   Luboshitzky R, 1996, CLIN ENDOCRINOL, V45, P749, DOI 10.1046/j.1365-2265.1996.8710881.x
   MACDONALD M, 1994, HUM MOL GENET, V3, P1365, DOI 10.1093/hmg/3.8.1365
   Mameli C, 2022, NUTRIENTS, V14, DOI 10.3390/nu14102107
   Mancini A, 2008, J ANDROL, V29, P622, DOI 10.2164/jandrol.107.004838
   Mavinkurve M, 2015, BBA CLIN, V3, P304, DOI 10.1016/j.bbacli.2015.04.005
   Miao L, 2009, FREE RADICAL BIO MED, V47, P344, DOI 10.1016/j.freeradbiomed.2009.05.018
   Micangeli G, 2023, CHILDREN-BASEL, V10, DOI 10.3390/children10101672
   Micangeli G, 2023, ITAL J PEDIATR, V49, DOI 10.1186/s13052-023-01466-z
   Micangeli G, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11101983
   Mohamad NV, 2020, ENDOCR METAB IMMUNE, V20, P1478, DOI 10.2174/1871530320666200604160614
   Muranov KO, 2024, BIOCHEMISTRY-MOSCOW+, V89, pS112, DOI 10.1134/S0006297924140074
   Murphy MP, 2009, BIOCHEM J, V417, P1, DOI 10.1042/BJ20081386
   Nagaoka SI, 2012, NAT REV GENET, V13, P493, DOI 10.1038/nrg3245
   Nassau DE, 2020, FERTIL STERIL, V113, P489, DOI 10.1016/j.fertnstert.2020.01.003
   Oroian BA, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/5599265
   Otter M, 2010, EUR J HUM GENET, V18, P265, DOI 10.1038/ejhg.2009.109
   Padayatty SJ, 2003, J AM COLL NUTR, V22, P18, DOI 10.1080/07315724.2003.10719272
   Pagano G, 2012, ADV EXP MED BIOL, V724, P291, DOI 10.1007/978-1-4614-0653-2_22
   Palmieri F, 2013, MOL ASPECTS MED, V34, P465, DOI 10.1016/j.mam.2012.05.005
   Panvino F, 2024, CHILDREN-BASEL, V11, DOI 10.3390/children11050509
   Paparella R, 2025, PHARMACEUTICS, V17, DOI 10.3390/pharmaceutics17010118
   Paparella R, 2025, EUR J PEDIATR, V184, DOI 10.1007/s00431-024-05944-2
   Paparella R, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25042214
   Petrella C, 2021, CURR MED CHEM, V28, P7595, DOI 10.2174/0929867328666210504113445
   Pober Barbara R, 2010, N Engl J Med, V362, P239, DOI 10.1056/NEJMra0903074
   Poljsak B, 2011, OXID MED CELL LONGEV, V2011, DOI 10.1155/2011/194586
   Pomatto LCD, 2017, CURR BIOL, V27, P1, DOI 10.1016/j.cub.2016.10.044
   Pozza C, 2023, J CLIN ENDOCR METAB, V108, P2486, DOI 10.1210/clinem/dgad205
   Profeta G, 2022, Clin Ter, V173, P475, DOI 10.7417/CT.2022.2466
   RAPPOLD GA, 1993, HUM GENET, V92, P315, DOI 10.1007/BF01247327
   Ricciardi G, 2022, CHILDREN-BASEL, V9, DOI 10.3390/children9111719
   RILEY PA, 1994, INT J RADIAT BIOL, V65, P27, DOI 10.1080/09553009414550041
   Roh M, 2012, J CELL PHYSIOL, V227, P801, DOI 10.1002/jcp.22793
   Ross JL, 2017, J PEDIATR-US, V185, P193, DOI 10.1016/j.jpeds.2017.02.036
   Rouen A, 2023, TRANSL ANDROL UROL, V12, P1204, DOI 10.21037/tau-22-587
   SCHOBER E, 1989, CLIN ENDOCRINOL, V31, P475, DOI 10.1111/j.1365-2265.1989.tb01271.x
   Shkurat M.A., 2023, Ecol. Genet, V21, P261, DOI [10.17816/ecogen562714, DOI 10.17816/ECOGEN562714]
   Sies H, 2020, NAT REV MOL CELL BIO, V21, P363, DOI 10.1038/s41580-020-0230-3
   Sies H, 2017, REDOX BIOL, V11, P613, DOI 10.1016/j.redox.2016.12.035
   Skuse David, 2018, Handb Clin Neurol, V147, P355, DOI 10.1016/B978-0-444-63233-3.00024-5
   Song JP, 2020, CHINESE MED J-PEKING, V133, P1617, DOI 10.1097/CM9.0000000000000868
   Spaziani M, 2024, J CLIN ENDOCR METAB, V109, pe1564, DOI 10.1210/clinem/dgad730
   Spaziani M, 2020, AM J MED GENET C, V184, P334, DOI 10.1002/ajmg.c.31792
   Stadtman ER, 1998, DRUG METAB REV, V30, P225, DOI 10.3109/03602539808996310
   Stahl W, 2005, BBA-MOL BASIS DIS, V1740, P101, DOI 10.1016/j.bbadis.2004.12.006
   Stefania D, 2021, CRIT REV FOOD SCI, V61, P1804, DOI 10.1080/10408398.2020.1765736
   Steiner Margaret, 2022, Adv Pediatr, V69, P177, DOI 10.1016/j.yapd.2022.03.004
   Strain J J, 1992, EXS, V62, P419
   Sybert VP, 2004, NEW ENGL J MED, V351, P1227, DOI 10.1056/NEJMra030360
   Tam NNC, 2003, AM J PATHOL, V163, P2513, DOI 10.1016/S0002-9440(10)63606-1
   Tan DX, 2015, MOLECULES, V20, P18886, DOI 10.3390/molecules201018886
   Tarani L, 2023, ENDOCR METAB IMMUNE, V23, P105, DOI 10.2174/1871530322666220704101310
   Tartaglia N, 2011, ACTA PAEDIATR, V100, P851, DOI 10.1111/j.1651-2227.2011.02235.x
   Tartaglia NR, 2010, ORPHANET J RARE DIS, V5, DOI 10.1186/1750-1172-5-8
   Teleanu DM, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23115938
   Terracina S, 2024, ANTIOXIDANTS-BASEL, V13, DOI 10.3390/antiox13040410
   Tostes RC, 2016, AM J PHYSIOL-REG I, V310, pR1, DOI 10.1152/ajpregu.00392.2014
   Tremellen K, 2008, HUM REPROD UPDATE, V14, P243, DOI 10.1093/humupd/dmn004
   Tresserra-Rimbau A, 2020, NUTRIENTS, V12, DOI 10.3390/nu12092893
   Usui N, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24065487
   Vassalle C, 2017, JPAD-J PREV ALZHEIM, V4, P58, DOI 10.14283/jpad.2016.109
   Vázquez-González D, 2023, ADV EXP MED BIOL, V1411, P327, DOI 10.1007/978-981-19-7376-5_15
   Vilas-Boas EA, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10123328
   Visootsak J, 2006, ORPHANET J RARE DIS, V1, DOI 10.1186/1750-1172-1-42
   Voziyan P.A., 2014, J. Bioequivalence Bioavailab, V6, DOI [10.4172/jbb.10000e57, DOI 10.4172/JBB.10000E57]
   Wang CY, 2013, TISSUE CELL, V45, P47, DOI 10.1016/j.tice.2012.09.004
   White RE, 2010, STEROIDS, V75, P788, DOI 10.1016/j.steroids.2009.12.007
   Wickens AP, 2001, RESP PHYSIOL, V128, P379, DOI 10.1016/S0034-5687(01)00313-9
   Wilson MA, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000568
   Winterbourn CC, 2008, NAT CHEM BIOL, V4, P278, DOI 10.1038/nchembio.85
   Winterbourn CC, 2013, ANTIOXID REDOX SIGN, V18, P642, DOI 10.1089/ars.2012.4827
   Wisnuwardani RW, 2019, EUR J NUTR, V58, P2345, DOI 10.1007/s00394-018-1787-x
   Wu JB, 2009, FASEB J, V23, P4029, DOI 10.1096/fj.09-139097
   Yamamoto KS, 2024, HUM GENOME VAR, V11, DOI 10.1038/s41439-024-00289-6
   Zhu CL, 2007, EUR J NEUROSCI, V26, P3402, DOI 10.1111/j.1460-9568.2007.05948.x
   Zitzmann M, 2021, ANDROLOGY-US, V9, P145, DOI 10.1111/andr.12909
NR 168
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD APR 29
PY 2025
VL 14
IS 5
AR 531
DI 10.3390/antiox14050531
PG 25
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 3AP0Z
UT WOS:001495766500001
PM 40427413
DA 2025-06-11
ER

PT J
AU Veltman, EM
   Lamers, F
   Comijs, HC
   Stek, ML
   van der Mast, RC
   Rhebergen, D
AF Veltman, E. M.
   Lamers, F.
   Comijs, H. C.
   Stek, M. L.
   van der Mast, R. C.
   Rhebergen, D.
TI Inflammatory markers and cortisol parameters across depressive subtypes
   in an older cohort
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Review
DE Latent class analysis; Depression subtypes; Inflammation; Cortisol;
   Atypical depression; Melancholic depression
ID ADRENAL AXIS ACTIVITY; LATE-LIFE DEPRESSION; UNDER-THE-CURVE; METABOLIC
   SYNDROME; SALIVARY CORTISOL; MAJOR DEPRESSION; SYMPTOMS; ASSOCIATION;
   TIME
AB Background: There is growing evidence that inflammatory and cortisol dysregulation are underlying pathophysiological mechanisms in the aetiology of major depressive disorder, particularly in younger adults. However, findings of biological disturbances in late-life depression have been divergent, probably due to the even greater heterogeneity of depression in older adults with aging processes influencing biological factors. Using empirically derived subtypes may enable the identification of biological disturbances underlying depression in older adults.
   Methods: Data were used from the Netherlands Study of Depression in Older Persons (NESDO) of 359 persons aged 60 years or older, with a current diagnosis of major depressive disorder (MDD). Depressive subtypes (severe atypical, severe melancholic, and moderate severe subtype) that were previously identified through latent class analysis (LCA), were examined on differences in inflammatory markers including C-reactive protein (CRP), in-terleukin-6 (IL-6), and neutrophil gelatinase-associated lipocalin (NGAL), as well as cortisol parameters.
   Results: No differences in measures for inflammation and cortisol across subtypes were observed in uncorrected or for putative confounders corrected models.
   Limitations: Several subjects had missing cortisol and inflammatory data, decreasing the power. However, results did not change after imputation analysis.
   Discussion: In this cohort of depressed older adults, no differences in inflammation and cortisol measures between depression subtypes were observed. This is probably due to the many (patho) physiological processes that are involved in aging, thereby clouding the results.
C1 [Veltman, E. M.; van der Mast, R. C.] Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.
   [Lamers, F.; Comijs, H. C.; Stek, M. L.; Rhebergen, D.] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, GGZ InGeest, Amsterdam, Netherlands.
   [Lamers, F.; Comijs, H. C.; Stek, M. L.; Rhebergen, D.] Vrije Univ Amsterdam, Med Ctr, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands.
   [van der Mast, R. C.] Univ Antwerp, CAPRI, Dept Psychiat, Antwerp, Belgium.
C3 Leiden University; Leiden University Medical Center (LUMC); Leiden
   University - Excl LUMC; Vrije Universiteit Amsterdam; Vrije Universiteit
   Amsterdam; University of Antwerp
RP Veltman, EM (corresponding author), Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.
EM evelineveltman@gmail.com
RI Lamers, Femke/G-5161-2012
OI Lamers, Femke/0000-0003-4344-5766
FU European Union Seventh Framework Programme [PCIG12-GA-2012-334065];
   Fonds NutsOhra [0701-065]; Stichting totSteun VCVGZ; NARSAD The Brain
   and Behaviour Research Fund [41080]; VU University Medical Center;
   Leiden University Medical Center; University Medical Center Groningen;
   UMC St Radboud; GGZ inGeest; GG Net; GGZ Nijmegen; Parnassia
FX FL has received funding from the European Union Seventh Framework
   Programme (FP7/2007-2013) under grant agreement No.
   PCIG12-GA-2012-334065.The infrastructure for the NESDO study
   (http://nesdo.amstad.nl) is funded through the Fonds NutsOhra (project
   0701-065), Stichting totSteun VCVGZ, NARSAD The Brain and Behaviour
   Research Fund (grand ID 41080), and the participating universities and
   mental health care organizations (VU University Medical Center, Leiden
   University Medical Center, University Medical Center Groningen, UMC St
   Radboud, and GGZ inGeest, GG Net, GGZ Nijmegen and Parnassia).
CR Andrews G, 1998, SOC PSYCH PSYCH EPID, V33, P80, DOI 10.1007/s001270050026
   Balardin JB, 2011, J GERIATR PSYCH NEUR, V24, P19, DOI 10.1177/0891988710373599
   Berk M, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-74
   Bremmer MA, 2008, J AFFECT DISORDERS, V106, P249, DOI 10.1016/j.jad.2007.07.002
   Bremmer MA, 2007, BIOL PSYCHIAT, V62, P479, DOI 10.1016/j.biopsych.2006.11.033
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Comijs Hannie C, 2011, BMC Res Notes, V4, P524, DOI 10.1186/1756-0500-4-524
   Djernes JK, 2006, ACTA PSYCHIAT SCAND, V113, P372, DOI 10.1111/j.1600-0447.2006.00770.x
   Duivis HE, 2011, AM J PSYCHIAT, V168, P913, DOI 10.1176/appi.ajp.2011.10081163
   Edwards S, 2001, PSYCHONEUROENDOCRINO, V26, P613, DOI 10.1016/S0306-4530(01)00015-4
   Fekedulegn DB, 2007, PSYCHOSOM MED, V69, P651, DOI 10.1097/PSY.0b013e31814c405c
   FOLSTEIN MF, 1975, J PSYCHIAT RES, V12, P189, DOI 10.1016/0022-3956(75)90026-6
   Gold PW, 2002, MOL PSYCHIATR, V7, P254, DOI 10.1038/sj.mp.4001032
   Hybels CF, 2012, INT J GERIATR PSYCH, V27, P601, DOI 10.1002/gps.2759
   Hybels CF, 2009, AM J GERIAT PSYCHIAT, V17, P387, DOI 10.1097/JGP.0b013e31819431ff
   Kahl KG, 2012, EUR ARCH PSY CLIN N, V262, P313, DOI 10.1007/s00406-011-0277-4
   Knorr U, 2010, PSYCHONEUROENDOCRINO, V35, P1275, DOI 10.1016/j.psyneuen.2010.04.001
   Kriegsman DMW, 1996, J CLIN EPIDEMIOL, V49, P1407, DOI 10.1016/S0895-4356(96)00274-0
   Kuo SY, 2011, PSYCHOL MED, V41, P1665, DOI 10.1017/S0033291710002473
   Lamers F, 2013, MOL PSYCHIATR, V18, P692, DOI 10.1038/mp.2012.144
   Lee CT, 2012, INT J GERIATR PSYCH, V27, P1061, DOI 10.1002/gps.2824
   Marijnissen RM, 2014, BRAIN BEHAV IMMUN, V37, P231, DOI 10.1016/j.bbi.2013.12.021
   Merkert S, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17071000
   Mezuk B, 2012, PSYCHOL MED, V42, P2037, DOI 10.1017/S003329171200027X
   Milaneschi Y, 2016, MOL PSYCHIATR, V21, P516, DOI 10.1038/mp.2015.86
   Miller AH, 2016, NAT REV IMMUNOL, V16, P22, DOI 10.1038/nri.2015.5
   Murri MB, 2014, PSYCHONEUROENDOCRINO, V41, P46, DOI 10.1016/j.psyneuen.2013.12.004
   Naude P. J., 2015, J PSYCHOSOM RES, V75, P444
   Nelson JC, 1997, AM J PSYCHIAT, V154, P1497, DOI 10.1176/ajp.154.11.1497
   Penninx BWJH, 2007, AM J GERIAT PSYCHIAT, V15, P522, DOI 10.1097/JGP.0b013e318033ed80
   Penninx BWJH, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-129
   Pruessner JC, 2003, PSYCHONEUROENDOCRINO, V28, P916, DOI 10.1016/S0306-4530(02)00108-7
   Rhebergen D, 2015, PSYCHONEUROENDOCRINO, V51, P341, DOI 10.1016/j.psyneuen.2014.10.005
   Rothermundt M, 2001, J AFFECT DISORDERS, V63, P93, DOI 10.1016/S0165-0327(00)00157-9
   Rush AJ, 1996, PSYCHOL MED, V26, P477, DOI 10.1017/S0033291700035558
   SAUNDERS JB, 1993, ADDICTION, V88, P791, DOI 10.1111/j.1360-0443.1993.tb02093.x
   Schmidt-Reinwald A, 1999, LIFE SCI, V64, P1653, DOI 10.1016/S0024-3205(99)00103-4
   Stetler C, 2011, PSYCHOSOM MED, V73, P114, DOI 10.1097/PSY.0b013e31820ad12b
   van den Biggelaar AHJ, 2007, EXP GERONTOL, V42, P693, DOI 10.1016/j.exger.2007.01.011
   Veltman EM, 2017, J AFFECT DISORDERS, V218, P123, DOI 10.1016/j.jad.2017.04.059
   Viinamäki H, 2009, ACTA PSYCHIAT SCAND, V120, P23, DOI 10.1111/j.1600-0447.2008.01333.x
   Vogelzangs N, 2014, BRAIN BEHAV IMMUN, V41, P109, DOI 10.1016/j.bbi.2014.05.004
   VONKORFF M, 1992, PAIN, V50, P133, DOI 10.1016/0304-3959(92)90154-4
   Vreeburg SA, 2009, PSYCHONEUROENDOCRINO, V34, P1109, DOI 10.1016/j.psyneuen.2009.04.024
   Vreeburg SA, 2009, ARCH GEN PSYCHIAT, V66, P617, DOI 10.1001/archgenpsychiatry.2009.50
   World Health Organization (WHO), 1998, COMP INT DIAGN INT C
   Zalli A, 2016, PSYCHOPHARMACOLOGY, V233, P1669, DOI 10.1007/s00213-015-3919-9
NR 47
TC 22
Z9 26
U1 0
U2 27
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JUL
PY 2018
VL 234
BP 54
EP 58
DI 10.1016/j.jad.2018.02.080
PG 5
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA GB8EK
UT WOS:000429308000009
PM 29522944
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Park, JE
   Lee, JE
AF Park, Jong Eun
   Lee, Jung Eun
TI Cardiovascular disease risk factors and depression in Korean women:
   Results from the fourth Korean National Health and Nutrition Examination
   Survey
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Depression; Body mass index; Hyperlipidemia; Cardiovascular disease
ID MAJOR DEPRESSION; GENDER-DIFFERENCES; METABOLIC SYNDROME; GLOBAL BURDEN;
   SMOKING; EPIDEMIOLOGY; METAANALYSIS; MORTALITY; OBESITY; EVENTS
AB Depression is the fourth leading factor of disease burden for the global female population, but while increasing evidence has supported a contributing role of depression in cardiovascular disease, little is known about this association within the female population of Korea. We examined the association in a study of 5658 Korean women who participated in the fourth Korean National Health and Nutrition Examination Survey. A logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). A total of 279 cases of depression were included. Cardiovascular disease risk factors were associated with higher odds of depression: ORs (95% CIs) were 3.99(2.25-7.05) for current smokers with <5 pack-years vs. never-smokers, 1.97 (1.18-3.30) for >= 28 vs. <20 kg/m(2) of body mass index, 1.42 (1.03-1.95) for 100-125 vs. <100 mg/dL of fasting serum glucose levels, and 2.10 (1.46-3.03) for a history of hyperlipidemia. Women with a history of two or three comorbid disorders (diabetes, hypertension, and cardiovascular disease) had a 1.63-fold higher OR for depression than women without any of these diseases. Korean women with depression had a greater prevalence of major risk factors for cardiovascular disease than women without depression. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
C1 [Park, Jong Eun; Lee, Jung Eun] Sookmyung Womens Univ, Dept Food & Nutr, Seoul 140742, South Korea.
C3 Sookmyung Women's University
RP Lee, JE (corresponding author), Sookmyung Womens Univ, Dept Food & Nutr, 52 Hyochangwon Gil, Seoul 140742, South Korea.
EM junglee@sm.ac.kr
RI Lee, Jung/AAC-5634-2020
OI Park, Jong Eun/0000-0002-4981-4238; Lee, Jung Eun/0000-0003-1141-878X
FU Sookmyung Women's University; Ministry of Education and Human Resources
   Development, Republic of Korea
FX This research was supported by the Sookmyung Women's University Research
   Grant (2010) and the Brain Korea 21 (BK 21) Project from the Ministry of
   Education and Human Resources Development, Republic of Korea.
CR Abe-Kim J, 2007, AM J PUBLIC HEALTH, V97, P91, DOI 10.2105/AJPH.2006.098541
   Ainsworth BE, 2000, MED SCI SPORT EXER, V32, pS498, DOI 10.1097/00005768-200009001-00009
   Breslau N, 1998, ARCH GEN PSYCHIAT, V55, P161, DOI 10.1001/archpsyc.55.2.161
   Carney RM, 2003, BIOL PSYCHIAT, V54, P241, DOI 10.1016/S0006-3223(03)00111-2
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   Davidson KW, 2006, PSYCHOSOM MED, V68, P645, DOI 10.1097/01.psy.0000233233.48738.22
   de Wit L, 2010, PSYCHIAT RES, V178, P230, DOI 10.1016/j.psychres.2009.04.015
   Frasure-Smith N, 2006, CAN J PSYCHIAT, V51, P730, DOI 10.1177/070674370605101202
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Jacka FN, 2007, PSYCHOSOMATICS, V48, P54, DOI 10.1176/appi.psy.48.1.54
   Je Cho， Maeng, 2009, [JOURNAL OF THE KOREAN NEUROPSYCHIATRIC ASSOCIATION, 신경정신의학], V48, P143
   Kim JM, 2006, BRIT J PSYCHIAT, V189, P26, DOI 10.1192/bjp.bp.105.015032
   Klungsoyr O, 2006, AM J EPIDEMIOL, V163, P421, DOI 10.1093/aje/kwj058
   Korea Centers for Disease Control and Prevention, 2008, MEN MEN AG HLTH IMP
   Korean Health Insurance Review and Assessment, 2010, PROP PAT REC MED CAR
   Kuehner C, 2003, ACTA PSYCHIAT SCAND, V108, P163, DOI 10.1034/j.1600-0447.2003.00204.x
   Lee C K, 1987, J Korean Med Sci, V2, P19
   Lett HS, 2004, PSYCHOSOM MED, V66, P305, DOI 10.1097/01.psy.0000126207.43307.c0
   Lopez AD, 1998, NAT MED, V4, P1241, DOI 10.1038/3218
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Musselman DL, 1998, ARCH GEN PSYCHIAT, V55, P580, DOI 10.1001/archpsyc.55.7.580
   Oh K, 2007, EPIDEMIOL HEALTH, V29, P139
   Pasco JA, 2008, BRIT J PSYCHIAT, V193, P322, DOI 10.1192/bjp.bp.107.046706
   Piccinelli M, 2000, BRIT J PSYCHIAT, V177, P486, DOI 10.1192/bjp.177.6.486
   조맹제, 2004, [JOURNAL OF THE KOREAN NEUROPSYCHIATRIC ASSOCIATION, 신경정신의학], V43, P470
   Scalco Andréia Zavaloni, 2005, Clinics, V60, P241, DOI 10.1590/S1807-59322005000300010
   Üstün TB, 2004, BRIT J PSYCHIAT, V184, P386, DOI 10.1192/bjp.184.5.386
   Van der Kooy K, 2007, INT J GERIATR PSYCH, V22, P613, DOI 10.1002/gps.1723
   van Melle JP, 2004, PSYCHOSOM MED, V66, P814, DOI 10.1097/01.psy.0000146294.82810.9c
   Wassertheil-Smoller S, 2004, ARCH INTERN MED, V164, P289, DOI 10.1001/archinte.164.3.289
   Weissman MM, 1996, JAMA-J AM MED ASSOC, V276, P293, DOI 10.1001/jama.276.4.293
   Whooley MA, 2008, JAMA-J AM MED ASSOC, V300, P2379, DOI 10.1001/jama.2008.711
   World Health Organization (WHO). Regional Office for the Western Pacific, 2000, AS PAC PERSP RED OBS
   Zweifel JE, 1997, PSYCHONEUROENDOCRINO, V22, P189, DOI 10.1016/S0306-4530(96)00034-0
NR 36
TC 14
Z9 14
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD DEC 30
PY 2011
VL 190
IS 2-3
BP 232
EP 239
DI 10.1016/j.psychres.2011.05.040
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 871FI
UT WOS:000298722900013
PM 21683455
DA 2025-06-11
ER

PT J
AU Li, SD
   Li, SL
   Duan, F
   Lu, BP
AF Li, Shudi
   Li, Suling
   Duan, Fei
   Lu, Baoping
TI Depression and NAFLD risk: A meta-analysis and Mendelian randomization
   study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; NAFLD; Meta-analysis; Mendelian randomization
ID FATTY LIVER-DISEASE; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   PHYSICAL-ACTIVITY; NATIONAL-HEALTH; ASSOCIATION; DISORDERS; ADULTS;
   LIFE; MORTALITY
AB Background: Both depression and nonalcoholic fatty liver disease (NAFLD) have a high global prevalence. Growing evidence suggests an association between depression and NAFLD, while the association remains unclear. Thus, in this study, we aimed to explore the effect of depression on the risk of developing NAFLD. Methods: The meta-analysis examined the association between depression and the risk of NAFLD by including observational studies. Relevant studies were searched in PubMed, Embase, the Cochrane Library, and Web of Science. Then a two-sample Mendelian randomization (MR) analysis was performed to explore causal association using genetic instruments identified from a genome-wide association study. Results: Six eligible studies were included in the meta-analysis, involving 289,22 depression cases among 167,554 participants. Meta-analysis showed a significant association between depression and a higher risk of developing NAFLD (OR = 1.14, 95 % CI: [1.05, 1.24], P = 0.002). However, we found no convincing evidence supporting a causal role of genetically predicted depression with NAFLD risk (OR = 0.861, 95 % CI: [0.598, 1.238], P = 0.420). Limitations: The insufficient number of included studies, the use of summary-level data, and restrictions on population sources are the major limiting factors. Conclusions: Meta-analysis and MR analysis demonstrated inconsistent results on the relationship between depression and a high risk of developing NAFLD. Specifically, meta-analysis confirmed that depression increases the risk of developing NAFLD, while MR analysis did not support a causal association between genetically determined depression and the risk of NAFLD.
C1 [Li, Shudi] Henan Univ Chinese Med, Clin Med Coll 2, Zhengzhou 450000, Peoples R China.
   [Li, Suling; Duan, Fei] Henan Univ TCM, Affiliated Hosp 1, Zhengzhou 450000, Peoples R China.
   [Lu, Baoping] Henan Univ Chinese Med, Zhengzhou 450046, Peoples R China.
   [Lu, Baoping] 156 Jinshui East Rd, Zhengzhou 450046, Henan, Peoples R China.
C3 Henan University of Traditional Chinese Medicine; Henan University of
   Traditional Chinese Medicine; Henan University of Traditional Chinese
   Medicine
RP Lu, BP (corresponding author), 156 Jinshui East Rd, Zhengzhou 450046, Henan, Peoples R China.
EM lbp1921@sohu.com
RI Duan, Fei/A-3830-2011
FU National famous traditional Chinese medicine Maudxi inherit-ance studio
   construction project [[2018] 119]; Henan Province Chinese medicine
   scientific research special topic [2022ZY1167]; National Clinical
   Research Base of Traditional Chinese Medicine, Henan Provincial Health
   Commission [2021 JDZX2014]
FX This study was supported by National famous traditional Chinese medicine
   Maudxi inherit-ance studio construction project (China Medical Office
   teaching Letter [2018] 119) , Henan Province Chinese medicine scientific
   research special topic (2022ZY1167) , National Clinical Research Base of
   Traditional Chinese Medicine, Henan Provincial Health Commission (2021
   JDZX2014) .
CR Abbafati C, 2020, LANCET, V396, P1204
   Anstee QM, 2020, J HEPATOL, V73, P505, DOI 10.1016/j.jhep.2020.04.003
   Battle Dolores Elaine, 2013, CoDAS, V25, P190
   Bica T, 2017, J NURS SCHOLARSHIP, V49, P389, DOI 10.1111/jnu.12303
   Bremmer MA, 2008, J AFFECT DISORDERS, V106, P249, DOI 10.1016/j.jad.2007.07.002
   Cai HW, 2023, J AFFECT DISORDERS, V334, P332, DOI 10.1016/j.jad.2023.04.093
   Carrier P, 2016, HEPAT MON, V16, DOI 10.5812/hepatmon.41564
   Chesney E, 2014, WORLD PSYCHIATRY, V13, P153, DOI 10.1002/wps.20128
   Cho IY, 2021, EPIDEMIOL PSYCH SCI, V30, DOI 10.1017/S204579602000116X
   Cotter TG, 2020, GASTROENTEROLOGY, V158, P1851, DOI 10.1053/j.gastro.2020.01.052
   Dattilo V, 2020, FRONT GENET, V11, DOI 10.3389/fgene.2020.00826
   Dayabandara M, 2017, NEUROPSYCH DIS TREAT, V13, DOI 10.2147/NDT.S113099
   Eslam M, 2020, HEPATOL INT, V14, P889, DOI 10.1007/s12072-020-10094-2
   Garvey WT, 2016, ENDOCR PRACT, V22, P1, DOI 10.4158/EP161365.GL
   Gheshlagh RG, 2016, IRAN RED CRESCENT ME, V18, DOI 10.5812/ircmj.26523
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Gracious BL, 2015, J CHILD ADOL PSYCHOP, V25, P602, DOI 10.1089/cap.2015.0007
   Kacavenda-Babovic D, 2021, ACTA CLIN CROAT, V60, P579, DOI 10.20471/acc.2021.60.04.03
   Kamari N, 2023, BMC GASTROENTEROL, V23, DOI 10.1186/s12876-023-02785-5
   Katsarou A, 2020, WORLD J GASTROENTERO, V26, P1993, DOI 10.3748/wjg.v26.i17.1993
   Keller J, 2017, MOL PSYCHIATR, V22, P527, DOI 10.1038/mp.2016.120
   Kim D, 2019, ALIMENT PHARM THER, V50, P590, DOI 10.1111/apt.15395
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Konttinen H, 2010, AM J CLIN NUTR, V92, P1031, DOI 10.3945/ajcn.2010.29732
   Kucerova J, 2015, BIOMED PAP, V159, P208, DOI 10.5507/bp.2014.060
   Laursen TM, 2016, J AFFECT DISORDERS, V193, P203, DOI 10.1016/j.jad.2015.12.067
   Lee JW, 2021, J AFFECT DISORDERS, V278, P259, DOI 10.1016/j.jad.2020.09.073
   Liang YJ, 2021, BRIT J NUTR, V126, P1771, DOI 10.1017/S0007114521000659
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Silva NDLE, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00057
   Marrie RA, 2021, WORLD PSYCHIATRY, V20, P298, DOI 10.1002/wps.20873
   Maurice J, 2018, CLIN MED, V18, P245, DOI 10.7861/clinmedicine.18-3-245
   Miller AH, 2016, NAT REV IMMUNOL, V16, P22, DOI 10.1038/nri.2015.5
   Moussavi S, 2007, LANCET, V370, P851, DOI 10.1016/S0140-6736(07)61415-9
   Mouzaki M, 2019, J PEDIATR GASTR NUTR, V69, P339, DOI 10.1097/MPG.0000000000002401
   Page MJ, 2021, BMJ-BRIT MED J, V372, DOI [10.1136/bmj.n71, 10.1136/bmj.n160]
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Park SJ, 2016, J AFFECT DISORDERS, V205, P393, DOI 10.1016/j.jad.2016.08.022
   Powell EE, 2021, LANCET, V397, P2212, DOI 10.1016/S0140-6736(20)32511-3
   Prince SA, 2008, INT J BEHAV NUTR PHY, V5, DOI 10.1186/1479-5868-5-56
   Roriz-Cruz M, 2007, J AM GERIATR SOC, V55, P374, DOI 10.1111/j.1532-5415.2007.01068.x
   Shao Q, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.711835
   Singh MK, 2019, HORM BEHAV, V108, P73, DOI 10.1016/j.yhbeh.2018.03.009
   Smith GI, 2020, J CLIN INVEST, V130, P1453, DOI 10.1172/JCI134165
   Soto-Angona O, 2020, BMC MED, V18, DOI 10.1186/s12916-020-01713-8
   Stang A, 2010, EUR J EPIDEMIOL, V25, P603, DOI 10.1007/s10654-010-9491-z
   Tarantino G, 2013, WORLD J GASTROENTERO, V19, P3375, DOI 10.3748/wjg.v19.i22.3375
   van der Feltz-Cornelis CM, 2014, NEUROPSYCH DIS TREAT, V10, P1057, DOI 10.2147/NDT.S59958
   Vanni E, 2010, DIGEST LIVER DIS, V42, P320, DOI 10.1016/j.dld.2010.01.016
   Wang L, 2016, ONCOTARGET, V7, P35632, DOI 10.18632/oncotarget.9691
   Watson K, 2018, NEUROPHARMACOLOGY, V136, P327, DOI 10.1016/j.neuropharm.2017.11.038
NR 51
TC 4
Z9 4
U1 3
U2 23
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD MAY 1
PY 2024
VL 352
BP 379
EP 385
DI 10.1016/j.jad.2024.02.074
EA FEB 2024
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA NT3O5
UT WOS:001202668300001
PM 38387674
OA hybrid
DA 2025-06-11
ER

PT J
AU Chang, NT
   Su, TC
AF Chang, Nien-Tzu
   Su, Ta-Chen
TI Investigating the association between familial hypercholesterolemia and
   perceived depression
SO ATHEROSCLEROSIS SUPPLEMENTS
LA English
DT Article
DE Familial hypercholesterolemia; Depression; Coronary heart disease
ID CORONARY-HEART-DISEASE; QUALITY-OF-LIFE; RISK-FACTOR;
   CARDIOVASCULAR-DISEASE; GENDER-DIFFERENCES; METABOLIC SYNDROME;
   YOUNG-ADULTS; HEALTH; EXPERIENCES; PREVALENCE
AB Background and aims: Inherited familial hypercholesterolemia (FH) increases cardiovascular risks, but perceived depression in FH is unknown. This study aims to explore the association between the FH and perceived depression.
   Methods: This study was a hospital-based design, we started to recruit clinical diagnosis of phenotypic FH since 2014 for the Ten Countries Study in the Asia-Pacific region. We consecutively recruited 302 FH patients and other 414 comparison subjects (214 subjects with hypertriglyceridemia and 200 subjects with normal lipid controls) from the special lipid clinic of National Taiwan University Hospital, Taipei. All participants received cardiovascular health examinations and completed a self-reported questionnaire, including the Center for Epidemiologic Studies Depression Scale (CES-D) for assessment of the psychosocial depression.
   Results: Clinical FH patients had a higher risk of perceived depression, with an odds ratio (95% confidence intervals) of possible depression by 1.50 (1.07-2.11) and probable depression by 1.73 (1.10-2.75) than those of the non-FH groups after adjusted relevant cardiovascular risk factors. FH patients with a family history of coronary heart disease (CHD) had higher domain-specific depression scores than those of controls. In addition, this study found that FH patients with lower educational levels also had a higher risk of depression compared with those in control groups.
   Conclusions: Patients with clinical phenotype of FH are associated with subjectively perceived depression, particularly among FH patients with a family history of CHD. (c) 2019 Elsevier B.V. All rights reserved.
C1 [Chang, Nien-Tzu] Natl Taiwan Univ, Sch Nursing, Coll Med, Taipei 10002, Taiwan.
   [Su, Ta-Chen] Natl Taiwan Univ Hosp, Dept Internal Med, 7 Chung Shan South Rd, Taipei 10002, Taiwan.
   [Su, Ta-Chen] Natl Taiwan Univ Hosp, Cardiovasc Ctr, 7 Chung Shan South Rd, Taipei 10002, Taiwan.
   [Su, Ta-Chen] Natl Taiwan Univ, Coll Publ Hlth, Inst Occupat Med & Ind Hyg, Taipei 10020, Taiwan.
   [Su, Ta-Chen] Natl Taiwan Univ Hosp, Dept Environm & Occupat Med, Taipei, Taiwan.
   [Su, Ta-Chen] Natl Taiwan Univ, Coll Med, Taipei, Taiwan.
C3 National Taiwan University; National Taiwan University; National Taiwan
   University Hospital; National Taiwan University; National Taiwan
   University Hospital; National Taiwan University; National Taiwan
   University; National Taiwan University Hospital; National Taiwan
   University
RP Su, TC (corresponding author), Natl Taiwan Univ Hosp, Dept Internal Med, 7 Chung Shan South Rd, Taipei 10002, Taiwan.; Su, TC (corresponding author), Natl Taiwan Univ Hosp, Cardiovasc Ctr, 7 Chung Shan South Rd, Taipei 10002, Taiwan.
EM tachensu@gmail.com
RI , shen/GXH-0183-2022
OI SU, TA-CHEN/0000-0001-7523-7166; Chang, Nien-Tzu/0000-0001-7611-3843
FU National Science Council of Taiwan [NSC102-2314-B-002-004]; National
   Taiwan University [NTU-CDP-104R7811]; National Taiwan University
   Hospital [NTUH 106-S3521]
FX This study was supported by research grants from the National Science
   Council of Taiwan (NSC102-2314-B-002-004) and National Taiwan University
   (NTU-CDP-104R7811). This study was also supported by the National Taiwan
   University Hospital (NTUH 106-S3521).
CR Austin MA, 2004, AM J EPIDEMIOL, V160, P407, DOI 10.1093/aje/kwh236
   Azzopardi S, 2009, J CARDIOVASC NURS, V24, P232, DOI 10.1097/JCN.0b013e31819b2125
   Barth J, 2004, PSYCHOSOM MED, V66, P802, DOI 10.1097/01.psy.0000146332.53619.b2
   BOND AJ, 1993, BRIT J PSYCHIAT, V163, P666, DOI 10.1192/bjp.163.5.666
   Bouhairie VE, 2015, CARDIOL CLIN, V33, P169, DOI 10.1016/j.ccl.2015.01.001
   Carney RM, 2002, J PSYCHOSOM RES, V53, P897, DOI 10.1016/S0022-3999(02)00311-2
   Chien C P, 1985, Seishin Shinkeigaku Zasshi, V87, P335
   Civeira F, 2004, ATHEROSCLEROSIS, V173, P55, DOI 10.1016/j.atherosclerosis.2003.11.010
   Erbel R, 2012, EUR HEART J, V33, P1201, DOI 10.1093/eurheartj/ehs076
   Federico A., 1993, GeneReviews((R))
   FUJIYAMA J, 1991, CLIN CHIM ACTA, V200, P1, DOI 10.1016/0009-8981(91)90328-A
   Gallagher R, 2009, J ADV NURS, V65, P2386, DOI 10.1111/j.1365-2648.2009.05101.x
   Goldberg AC, 2016, CIRCULATION, V133, P1054, DOI 10.1161/CIRCULATIONAHA.116.021673
   Harrington C, 2011, OMEGA-J DEATH DYING, V64, P65, DOI 10.2190/OM.64.1.e
   Harris George D, 2004, Mo Med, V101, P222
   Hoeman S.P., 2008, Rehabilitation nursing: Prevention, intervention, and outcomes
   Hsu SHJ, 2016, J OCCUP ENVIRON MED, V58, P728, DOI 10.1097/JOM.0000000000000760
   Huang CJ, 2013, INT J CARDIOL, V168, P4711, DOI 10.1016/j.ijcard.2013.07.173
   Julian LJ, 2011, ARTHRIT CARE RES, V63, P884, DOI 10.1002/acr.20447
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Larsen MK, 2012, J FORENSIC SCI, V57, P658, DOI 10.1111/j.1556-4029.2011.02028.x
   Lichtman JH, 2014, CIRCULATION, V129, P1350, DOI 10.1161/CIR.0000000000000019
   Lippi G, 2009, SEMIN THROMB HEMOST, V35, P325, DOI 10.1055/s-0029-1222611
   Lovlien M, 2008, J ADV NURS, V63, P148, DOI 10.1111/j.1365-2648.2008.04654.x
   Mayer DM, 2013, APPL NURS RES, V26, P168, DOI 10.1016/j.apnr.2013.06.007
   McKee G, 2013, J CLIN NURS, V22, P2758, DOI 10.1111/jocn.12233
   Nordestgaard BG, 2013, EUR HEART J, V34, P3478, DOI 10.1093/eurheartj/eht273
   Piccinelli M, 2000, BRIT J PSYCHIAT, V177, P486, DOI 10.1192/bjp.177.6.486
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Saleptsis VG, 2011, INT ANGIOL, V30, P97
   Singh P, 2015, MED HYPOTHESES, V84, P370, DOI 10.1016/j.mehy.2015.01.033
   Sofou K, 2013, J CHILD NEUROL, V28, P663, DOI 10.1177/0883073813481622
   Tziallas D, 2012, EUR J CARDIOVASC NUR, V11, P297, DOI 10.1016/j.ejcnurse.2011.02.004
   Uren A, 2015, J ADV NURS, V71, P349, DOI 10.1111/jan.12499
   Wang WR, 2014, J ADV NURS, V70, P2932, DOI 10.1111/jan.12397
   Watts GF, 2016, J ATHEROSCLER THROMB, V23, P891, DOI 10.5551/jat.35949
   WHO, 2001, MENT HLTH REP WHO
NR 37
TC 7
Z9 7
U1 0
U2 2
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1567-5688
EI 1878-5050
J9 ATHEROSCLEROSIS SUPP
JI Atheroscler. Suppl.
PD MAR
PY 2019
VL 36
BP 31
EP 36
DI 10.1016/j.atherosclerosissup.2019.01.007
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA HO4NV
UT WOS:000460900500007
PM 30876531
DA 2025-06-11
ER

PT J
AU Boylan, JM
   Ryff, CD
AF Boylan, Jennifer Morozink
   Ryff, Carol D.
TI Psychological Well-Being and Metabolic Syndrome: Findings From the
   Midlife in the United States National Sample
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
ID MENTAL-HEALTH; OLDER-ADULTS; LIFE; THERAPY; INTERLEUKIN-6;
   PSYCHOTHERAPY; ASSOCIATION; PROTOCOL; RISK
AB Objectives
   Psychological well-being predicts favorable cardiovascular outcomes, but less evidence addresses biological mediators underlying these effects. Therefore, associations among well-being and metabolic syndrome (MetSyn) were examined in a national sample.
   Methods
   Survey of Midlife in the US participants (MIDUS; n = 1205) provided survey assessments of hedonic (positive affect, life satisfaction) and eudaimonic well-being (e.g., personal growth and purpose in life) at two waves 9 to 10 years apart. MetSyn components were measured during an overnight clinic visit at Time 2 only. Outcomes included the number of MetSyn risk factors and a binary outcome reflective of MetSyn status.
   Results
   The unadjusted prevalence of MetSyn was 36.6%. Life satisfaction (B [standard error {SE}] = -0.12 [0.04], p = .005), positive affect (B [SE] = -0.10 [0.04], p = .009), and personal growth (B [SE] = -0.10 [0.04], p = .012) predicted fewer MetSyn components and lower risk of meeting diagnostic criteria in fully adjusted models.
   Results were unchanged by adjustments for depressive symptoms, and were not moderated by age, sex, race, or socioeconomic status. Life satisfaction (B [SE] = -0.11 [0.05], p = .023) and a eudaimonic well-being composite (B [SE] = -0.11 [0.05], p = .045) also predicted fewer components and lower risk of meeting diagnostic criteria in longitudinal models.
   Conclusions
   Psychosocial resources, including positive affect, life satisfaction, and personal growth, predicted reduced risk for MetSyn both cross sectionally and longitudinally. Further work should examine consequences of these linkages for cardiovascular outcomes in intervention contexts.
C1 [Boylan, Jennifer Morozink] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15213 USA.
   [Ryff, Carol D.] Univ Wisconsin, Dept Psychol, Madison, WI 53706 USA.
   [Ryff, Carol D.] Univ Wisconsin, Inst Aging, Madison, WI USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; University of Wisconsin System; University of Wisconsin
   Madison; University of Wisconsin System; University of Wisconsin Madison
RP Boylan, JM (corresponding author), Univ Pittsburgh, Dept Psychiat, 3811 OHara St, Pittsburgh, PA 15213 USA.
EM boylanja@upmc.edu
RI Boylan, Jennifer/B-9288-2016
OI Boylan, Jennifer/0000-0003-2597-1367
FU National Institute on Aging at the National Institutes of Health
   [P01-AG020166]; John D. and Catherine T. MacArthur Foundation Research
   Network on Successful Midlife Development; (Georgetown) from the General
   Clinical Research Centers Program [M01-RR023942]; (University of
   California, Los Angeles) from the General Clinical Research Centers
   Program [M01-RR00865]; (University of Wisconsin) from the Clinical and
   Translational Science Award program of the National Center for Research
   Resources, National Institutes of Health [1UL1RR025011]; National Heart,
   Lung, and Blood Institute [5T32HL007560-32]
FX Source of Funding and Conflicts of Interest: This work was supported by
   the National Institute on Aging at the National Institutes of Health
   (P01-AG020166) to conduct a longitudinal follow-up of the MIDUS
   investigation (Dr. Ryff). The original study was supported by the John
   D. and Catherine T. MacArthur Foundation Research Network on Successful
   Midlife Development. Support also came from the following grants:
   M01-RR023942 (Georgetown), M01-RR00865 (University of California, Los
   Angeles) from the General Clinical Research Centers Program, and
   1UL1RR025011 (University of Wisconsin) from the Clinical and
   Translational Science Award program of the National Center for Research
   Resources, National Institutes of Health. J.M.B. is supported by a
   training grant from the National Heart, Lung, and Blood Institute
   (5T32HL007560-32). The content is solely the responsibility of the
   authors and does not necessarily represent the official views of the
   National Heart, Lung, and Blood Institute or the National Institutes of
   Health. Both authors declare no conflicts of interest.
CR Boehm JK, 2013, AM J CARDIOL, V111, P1425, DOI 10.1016/j.amjcard.2013.01.292
   Boehm JK, 2012, PSYCHOL BULL, V138, P655, DOI 10.1037/a0027448
   Breitbart W, 2012, J CLIN ONCOL, V30, P1304, DOI 10.1200/JCO.2011.36.2517
   Brim OG, 2004, MAC FDN MEN, P1
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Fava GA, 2005, PSYCHOTHER PSYCHOSOM, V74, P26, DOI 10.1159/000082023
   Fava GA, 2004, AM J PSYCHIAT, V161, P1872, DOI 10.1176/appi.ajp.161.10.1872
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   Friedman EM, 2007, HEALTH PSYCHOL, V26, P305, DOI 10.1037/0278-6133.26.3.305
   Goldbacher EM, 2007, ANN BEHAV MED, V34, P240, DOI 10.1007/BF02874549
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Heller AS, 2013, PSYCHOL SCI, V24, P2191, DOI 10.1177/0956797613490744
   Human LJ, 2013, J PERS, V81, P249, DOI 10.1111/jopy.12002
   Infurna FJ, 2014, HEALTH PSYCHOL, V33, P85, DOI 10.1037/a0030208
   Keyes CLM, 2002, J PERS SOC PSYCHOL, V82, P1007, DOI 10.1037//0022-3514.82.6.1007
   Keyes CLM, 2005, J CONSULT CLIN PSYCH, V73, P539, DOI 10.1037/0022-006X.73.3.539
   Keyes CLM, 2002, J HEALTH SOC BEHAV, V43, P207, DOI 10.2307/3090197
   Kim ES, 2013, J PSYCHOSOM RES, V74, P427, DOI 10.1016/j.jpsychores.2013.01.013
   Kim ES, 2013, J BEHAV MED, V36, P124, DOI 10.1007/s10865-012-9406-4
   King LA, 2001, PERS SOC PSYCHOL B, V27, P798, DOI 10.1177/0146167201277003
   Love GD, 2010, J AGING HEALTH, V22, P1059, DOI 10.1177/0898264310374355
   Miller GE, 2011, PSYCHOL SCI, V22, P1591, DOI 10.1177/0956797611419170
   Morozink JA, 2010, HEALTH PSYCHOL, V29, P626, DOI 10.1037/a0021360
   Ostir GV, 2006, PSYCHOSOM MED, V68, P727, DOI 10.1097/01.psy.0000234028.93346.38
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Prenda KM, 2001, PSYCHOL AGING, V16, P206, DOI 10.1037//0882-7974.16.2.206
   Pressman SD, 2005, PSYCHOL BULL, V131, P925, DOI 10.1037/0033-2909.131.6.925
   Radler BT, 2010, J AGING HEALTH, V22, P307, DOI 10.1177/0898264309358617
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Ruini C, 2009, J CLIN PSYCHOL, V65, P510, DOI 10.1002/jclp.20592
   Ryan RM, 2001, ANNU REV PSYCHOL, V52, P141, DOI 10.1146/annurev.psych.52.1.141
   Ryff CD, 2008, J HAPPINESS STUD, V9, P13, DOI 10.1007/s10902-006-9019-0
   RYFF CD, 1995, J PERS SOC PSYCHOL, V69, P719
   Ryff CD, 2006, PSYCHOTHER PSYCHOSOM, V75, P85, DOI 10.1159/000090892
   RYFF CD, 1994, PSYCHOL AGING, V9, P195, DOI 10.1037/0882-7974.9.2.195
   RYFF CD, 1989, J PERS SOC PSYCHOL, V57, P1069, DOI 10.1037/0022-3514.57.6.1069
   Ryff CD, 2004, PHILOS T R SOC B, V359, P1383, DOI 10.1098/rstb.2004.1521
   Saloumi C, 2010, PSYCHOL HEALTH MED, V15, P314, DOI 10.1080/13548501003668711
   Schaefer SM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0080329
   Schmutte PS, 1997, J PERS SOC PSYCHOL, V73, P549, DOI 10.1037/0022-3514.73.3.549
   Steptoe A, 2005, NEUROBIOL AGING, V26, pS108, DOI 10.1016/j.neurobiolaging.2005.08.016
   Tsenkova VK, 2008, HEALTH PSYCHOL, V27, pS163, DOI 10.1037/0278-6133.27.2(Suppl.).S163
   Urry HL, 2004, PSYCHOL SCI, V15, P367, DOI 10.1111/j.0956-7976.2004.00686.x
   van der Spek N, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/1471-244X-14-22
   WATSON D, 1988, J PERS SOC PSYCHOL, V54, P1063, DOI 10.1037/0022-3514.54.6.1063
   World Health Organization, 1946, PREAMBL CONST WHO AD
NR 46
TC 57
Z9 71
U1 0
U2 41
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JUN
PY 2015
VL 77
IS 5
BP 548
EP 558
DI 10.1097/PSY.0000000000000192
PG 11
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA CK5FE
UT WOS:000356247100007
PM 25984827
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kosyreva, AM
   Sentyabreva, AV
   Tsvetkov, IS
   Makarova, OV
AF Kosyreva, Anna Mikhailovna
   Sentyabreva, Alexandra Vladislavovna
   Tsvetkov, Ivan Sergeevich
   Makarova, Olga Vasilievna
TI Alzheimer's Disease and Inflammaging
SO BRAIN SCIENCES
LA English
DT Review
DE inflammation; neurodegeneration; aging; atherosclerosis; metabolic
   syndrome; depression; Alzheimer's disease
ID INSULIN-DEGRADING ENZYME; NEURAL STEM-CELLS; AMYLOID-BETA; SYSTEMIC
   INFLAMMATION; COGNITIVE IMPAIRMENT; SELECTIVE AUTOPHAGY;
   DIABETES-MELLITUS; NUCLEUS BASALIS; MOUSE MODEL; IKK-BETA
AB Alzheimer's disease is one of the most common age-related neurodegenerative disorders. The main theory of Alzheimer's disease progress is the amyloid-beta cascade hypothesis. However, the initial mechanisms of insoluble forms of amyloid-beta formation and hyperphosphorylated tau protein in neurons remain unclear. One of the factors, which might play a key role in senile plaques and tau fibrils generation due to Alzheimer's disease, is inflammaging, i.e., systemic chronic low-grade age-related inflammation. The activation of the proinflammatory cell phenotype is observed during aging, which might be one of the pivotal mechanisms for the development of chronic inflammatory diseases, e.g., atherosclerosis, metabolic syndrome, type 2 diabetes mellitus, and Alzheimer's disease. This review discusses the role of the inflammatory processes in developing neurodegeneration, activated during physiological aging and due to various diseases such as atherosclerosis, obesity, type 2 diabetes mellitus, and depressive disorders.
C1 [Kosyreva, Anna Mikhailovna; Sentyabreva, Alexandra Vladislavovna; Tsvetkov, Ivan Sergeevich; Makarova, Olga Vasilievna] FSBI Petrovsky Natl Res Ctr Surg, Avtsyn Sci Res Inst Human Morphol, Moscow 117418, Russia.
RP Sentyabreva, AV (corresponding author), FSBI Petrovsky Natl Res Ctr Surg, Avtsyn Sci Res Inst Human Morphol, Moscow 117418, Russia.
EM alexandraasentyabreva@gmail.com
RI Tsv, Ivan/AAC-3517-2019; Kosyreva, Anna/U-3557-2019
OI Sentyabreva, Alexandra/0000-0001-5064-219X; Tsvetkov,
   Ivan/0000-0003-0946-1105; Kosyreva, Anna/0000-0002-6182-1799
FU  [122030200530-6]
FX Number of state registration of research, development, and technological
   work for civil purposes-122030200530-6.
CR Agostinho P, 2010, CURR PHARM DESIGN, V16, P2766, DOI 10.2174/138161210793176572
   Aisen PS, 2000, NEUROLOGY, V54, P588, DOI 10.1212/WNL.54.3.588
   Andrews SJ, 2021, ANN NEUROL, V89, P54, DOI 10.1002/ana.25918
   [Anonymous], 2018, DIABETES CARE, V41, pS1, DOI [10.2337/dc18-Sint01, 10.2337/dc18-SINT01]
   [Anonymous], 2016, Dementia
   Anstey KJ, 2020, J ALZHEIMERS DIS, V78, P3, DOI 10.3233/JAD-200674
   Arancio O, 2004, EMBO J, V23, P4096, DOI 10.1038/sj.emboj.7600415
   Arkan MC, 2005, NAT MED, V11, P191, DOI 10.1038/nm1185
   Arvanitakis Z, 2004, ARCH NEUROL-CHICAGO, V61, P661, DOI 10.1001/archneur.61.5.661
   Askarova S, 2020, FRONT CELL INFECT MI, V10, DOI 10.3389/fcimb.2020.00104
   Aslam F, 2018, ANN RHEUM DIS, V77, DOI 10.1136/annrheumdis-2017-212425
   Bahniwal M, 2017, CURR ALZHEIMER RES, V14, P731, DOI 10.2174/1567205014666170117104053
   Baruch K, 2014, SCIENCE, V346, P89, DOI 10.1126/science.1252945
   Bauernfeind FG, 2009, J IMMUNOL, V183, P787, DOI 10.4049/jimmunol.0901363
   Bhatia Vandana, 2021, J Neurol Sci, V421, P117253, DOI 10.1016/j.jns.2020.117253
   Biber K, 2007, TRENDS NEUROSCI, V30, P596, DOI 10.1016/j.tins.2007.08.007
   Brunnström HR, 2009, EUR J NEUROL, V16, P488, DOI 10.1111/j.1468-1331.2008.02503.x
   Byers AL, 2011, NAT REV NEUROL, V7, P323, DOI 10.1038/nrneurol.2011.60
   Caccamo A, 2017, NAT NEUROSCI, V20, P1236, DOI 10.1038/nn.4608
   Cai DS, 2005, NAT MED, V11, P183, DOI 10.1038/nm1166
   Campanella C, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19092603
   Canu E, 2012, NEUROBIOL AGING, V33, P1023, DOI 10.1016/j.neurobiolaging.2010.09.021
   Carreno G, 2021, NEUROPATH APPL NEURO, V47, P359, DOI 10.1111/nan.12689
   Carter CJ, 2017, FRONT AGING NEUROSCI, V9, DOI 10.3389/fnagi.2017.00408
   Castellani RJ, 2019, LAB INVEST, V99, P958, DOI 10.1038/s41374-019-0231-z
   Chai AMB, 2020, FEBS J, V287, P612, DOI 10.1111/febs.15148
   Chait A, 2020, FRONT CARDIOVASC MED, V7, DOI 10.3389/fcvm.2020.00022
   Chen GF, 2017, ACTA PHARMACOL SIN, V38, P1205, DOI 10.1038/aps.2017.28
   Chen VCH, 2018, J CLIN PSYCHIAT, V79, DOI 10.4088/JCP.16m11312
   Cheng C, 2014, J GERONTOL A-BIOL, V69, P1299, DOI 10.1093/gerona/glu073
   Cheng HW, 2016, INT J NEUROSCI, V126, P299, DOI 10.3109/00207454.2015.1015722
   Cheng YY, 2016, BRAIN BEHAV IMMUN, V53, P207, DOI 10.1016/j.bbi.2015.12.012
   Chi S, 2015, CURR ALZHEIMER RES, V12, P189, DOI 10.2174/1567205012666150204124310
   Chiang MC, 2016, EXP CELL RES, V347, P322, DOI 10.1016/j.yexcr.2016.08.013
   Choi BR, 2014, EXP MOL MED, V46, DOI 10.1038/emm.2013.147
   Christiansen T, 2005, INT J OBESITY, V29, P146, DOI 10.1038/sj.ijo.0802839
   Chung MM, 2015, BBA-MOL BASIS DIS, V1852, P720, DOI 10.1016/j.bbadis.2015.01.006
   Cook DG, 2003, AM J PATHOL, V162, P313, DOI 10.1016/S0002-9440(10)63822-9
   Cosentino F, 2020, EUR HEART J, V41, P255, DOI 10.1093/eurheartj/ehz486
   Craft S, 2017, J ALZHEIMERS DIS, V57, P1325, DOI 10.3233/JAD-161256
   D'Andrea MR, 2003, BRAIN RES, V982, P19, DOI 10.1016/S0006-8993(03)02881-6
   Dafsari FS, 2020, TRANSL PSYCHIAT, V10, DOI 10.1038/s41398-020-0839-1
   De Strooper B, 2003, NEURON, V38, P9, DOI 10.1016/S0896-6273(03)00205-8
   den Hartigh LJ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0108564
   Didier ES, 2012, IMMUN AGEING, V9, DOI 10.1186/1742-4933-9-25
   Dioguardi M, 2020, J CLIN MED, V9, DOI 10.3390/jcm9020495
   Dodig S, 2019, BIOCHEM MEDICA, V29, DOI 10.11613/BM.2019.030501
   Downs KP, 2020, MOL ASPECTS MED, V76, DOI 10.1016/j.mam.2020.100924
   Du XL, 2022, J ALZHEIMERS DIS, V87, P415, DOI 10.3233/JAD-215657
   Elahi FM, 2020, ALZHEIMERS DEMENT, V16, P681, DOI 10.1016/j.jalz.2019.09.004
   Fairley LH, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.624538
   Fakhoury M, 2018, CURR NEUROPHARMACOL, V16, P508, DOI 10.2174/1570159X15666170720095240
   Fan LW, 2017, NEURAL REGEN RES, V12, P366, DOI 10.4103/1673-5374.202926
   Fang CJ, 2016, PROTEIN CELL, V7, P11, DOI 10.1007/s13238-015-0222-9
   Farhad Shirin Zahra, 2014, Dent Res J (Isfahan), V11, P549
   Farrer LA, 1997, JAMA-J AM MED ASSOC, V278, P1349, DOI 10.1001/jama.278.16.1349
   Farris W, 2003, P NATL ACAD SCI USA, V100, P4162, DOI 10.1073/pnas.0230450100
   Feldman N, 2015, AGEING RES REV, V24, P29, DOI 10.1016/j.arr.2015.01.003
   Femminella GD, 2017, J DIABETES RES, V2017, DOI 10.1155/2017/7420796
   Fernandez-Vizarra P, 2012, BRAIN, V135, P2826, DOI 10.1093/brain/aws195
   Flores-Dorantes MT, 2020, FRONT NEUROSCI-SWITZ, V14, DOI 10.3389/fnins.2020.00863
   Franceschi C, 2000, ANN NY ACAD SCI, V908, P244
   Franceschi C, 2018, NAT REV ENDOCRINOL, V14, P576, DOI 10.1038/s41574-018-0059-4
   Franceschi C, 2017, TRENDS ENDOCRIN MET, V28, P199, DOI 10.1016/j.tem.2016.09.005
   Franceschi C, 2014, J GERONTOL A-BIOL, V69, pS4, DOI 10.1093/gerona/glu057
   Frost GR, 2019, FRONT AGING NEUROSCI, V11, DOI 10.3389/fnagi.2019.00337
   Gibbons GS, 2019, JAMA NEUROL, V76, P101, DOI 10.1001/jamaneurol.2018.2505
   Gombar S, 2012, BMC GENOMICS, V13, DOI 10.1186/1471-2164-13-353
   Gomez G, 2018, J ALZHEIMERS DIS, V65, P629, DOI 10.3233/JAD-180297
   Green DR, 2014, CELL, V157, P65, DOI 10.1016/j.cell.2014.02.049
   Green KN, 2006, J NEUROSCI, V26, P9047, DOI 10.1523/JNEUROSCI.2797-06.2006
   Green RC, 2009, JAMA-J AM MED ASSOC, V302, P2557, DOI 10.1001/jama.2009.1866
   Grimaldi LME, 2000, ANN NEUROL, V47, P361, DOI 10.1002/1531-8249(200003)47:3<361::AID-ANA12>3.0.CO;2-N
   Grimm MO, 2007, TRENDS MOL MED, V13, P337, DOI 10.1016/j.molmed.2007.06.004
   Gritsenko A, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.565924
   Grozeva D, 2019, CURR GENET MED REP, V7, P53, DOI 10.1007/s40142-019-0161-5
   Guarnieri G, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21176128
   Gudala K, 2013, J DIABETES INVEST, V4, P640, DOI 10.1111/jdi.12087
   Gui YX, 2020, BRAIN PATHOL, V30, P151, DOI 10.1111/bpa.12763
   Guo HT, 2015, NAT MED, V21, P677, DOI 10.1038/nm.3893
   Guo M, 2014, CLIN EXP PHARMACOL P, V41, P650, DOI 10.1111/1440-1681.12265
   Hampel H, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.00456
   Hansen DV, 2018, J CELL BIOL, V217, P459, DOI 10.1083/jcb.201709069
   Heneka MT, 2013, NATURE, V493, P674, DOI 10.1038/nature11729
   Hermida AP, 2012, EXPERT REV NEUROTHER, V12, P1339, DOI [10.1586/ern.12.127, 10.1586/ERN.12.127]
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Hölscher C, 2014, NEURAL REGEN RES, V9, P1870, DOI 10.4103/1673-5374.145342
   Hölscher C, 2010, VITAM HORM, V84, P331, DOI [10.1016/B978-0-12-381517-0.00013-8, 10.1016/S0083-6729(10)84005-1]
   Holmes C, 2013, NEUROPATH APPL NEURO, V39, P51, DOI 10.1111/j.1365-2990.2012.01307.x
   Holthoff VA, 2011, ALZHEIMERS RES THER, V3, DOI 10.1186/alzrt89
   Hsu CC, 2011, J ALZHEIMERS DIS, V24, P485, DOI 10.3233/JAD-2011-101524
   Hur JY, 2020, NATURE, V586, P735, DOI 10.1038/s41586-020-2681-2
   Ismail Z, 2017, JAMA PSYCHIAT, V74, P58, DOI 10.1001/jamapsychiatry.2016.3162
   Jack CR Jr, 2018, ALZHEIMERS DEMENT, V14, P535, DOI 10.1016/j.jalz.2018.02.018
   Jakubauskiene E, 2021, GENES-BASEL, V12, DOI 10.3390/genes12081272
   Jett S, 2022, FRONT AGING NEUROSCI, V14, DOI 10.3389/fnagi.2022.948219
   Jha NK, 2018, J ALZHEIMERS DIS, V62, P15, DOI 10.3233/JAD-170589
   Jura M, 2016, AGE, V38, DOI 10.1007/s11357-016-9884-3
   Kamboh MI, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.45
   Kamer AR, 2009, J NEUROIMMUNOL, V216, P92, DOI 10.1016/j.jneuroim.2009.08.013
   Kandimalla R, 2017, BBA-MOL BASIS DIS, V1863, P1078, DOI 10.1016/j.bbadis.2016.08.018
   Kehmeier MN, 2021, FRONT AGING-LAUSANNE, V2, DOI 10.3389/fragi.2021.791208
   Kellner A, 2009, ANN NEUROL, V65, P24, DOI 10.1002/ana.21475
   Kessing LV, 2004, J NEUROL NEUROSUR PS, V75, P1662, DOI 10.1136/jnnp.2003.031773
   Khan MI, 2018, SEMIN CANCER BIOL, V49, P75, DOI 10.1016/j.semcancer.2017.05.008
   Kim M, 2007, J BIOL CHEM, V282, P7825, DOI 10.1074/jbc.M609168200
   Köhler CA, 2017, ACTA PSYCHIAT SCAND, V135, P373, DOI 10.1111/acps.12698
   Kountouras J, 2006, NEUROLOGY, V66, P938, DOI 10.1212/01.wnl.0000203644.68059.5f
   Kriete Andres, 2008, Immun Ageing, V5, P5, DOI 10.1186/1742-4933-5-5
   Kuznik B. I, 2020, Uspekhi Fiziologicheskikh Nauk, V51, P51, DOI 10.31857/S030117982002006X
   Labzin LI, 2018, ANNU REV MED, V69, P437, DOI 10.1146/annurev-med-050715-104343
   Lall R, 2019, NEUROPSYCH DIS TREAT, V15, P1343, DOI 10.2147/NDT.S203103
   Landreth G, 2007, CURR ALZHEIMER RES, V4, P159, DOI 10.2174/156720507780362092
   LAWSON LJ, 1990, NEUROSCIENCE, V39, P151, DOI 10.1016/0306-4522(90)90229-W
   Li JX, 2012, NAT CELL BIOL, V14, P999, DOI 10.1038/ncb2562
   Li L, 2009, NEUROBIOL AGING, V30, P1091, DOI 10.1016/j.neurobiolaging.2007.10.011
   Li W, 2021, THERANOSTICS, V11, P222, DOI 10.7150/thno.49860
   Liang ZH, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000026967
   Libertini G., 2021, EVOLUTIONARY GERONTO, P1
   Lim Bryant, 2021, J Appl Lab Med, V6, P756, DOI 10.1093/jalm/jfaa171
   Loeffler DA, 2008, J NEUROINFLAMM, V5, DOI 10.1186/1742-2094-5-9
   López-Olóriz J, 2013, ATHEROSCLEROSIS, V230, P330, DOI 10.1016/j.atherosclerosis.2013.08.011
   Low KJY, 2022, J ADV RES, V36, P113, DOI 10.1016/j.jare.2021.05.007
   Leite DM, 2022, BRAIN COMMUN, V4, DOI 10.1093/braincomms/fcac039
   Ma C, 2022, MOLECULES, V27, DOI 10.3390/molecules27041210
   Madruga E, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22020740
   Marques-Vidal P, 2012, OBESITY FACTS, V5, P734, DOI 10.1159/000345045
   Marschallinger J, 2020, NAT NEUROSCI, V23, P194, DOI 10.1038/s41593-019-0566-1
   Mavri A, 2001, DIABETOLOGIA, V44, P2025, DOI 10.1007/s001250100007
   McGeer PL, 2001, ARCH NEUROL-CHICAGO, V58, P1790, DOI 10.1001/archneur.58.11.1790
   Mengel D, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2012.151
   Merelli A, 2018, CURR NEUROPHARMACOL, V16, P1484, DOI 10.2174/1570159X16666180110130253
   Meriin AB, 2005, INT J HYPERTHER, V21, P403, DOI 10.1080/02656730500041871
   Mesulam MM, 2013, J COMP NEUROL, V521, P4124, DOI 10.1002/cne.23415
   MESULAM MM, 1983, J COMP NEUROL, V214, P170, DOI 10.1002/cne.902140206
   Mijit M, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10030420
   Moller HJ, 1998, EUR ARCH PSY CLIN N, V248, P111, DOI 10.1007/s004060050027
   Montagne A, 2020, STROKE, V51, P699, DOI 10.1161/STROKEAHA.119.028814
   Morgan BP, 2018, SEMIN IMMUNOPATHOL, V40, P113, DOI 10.1007/s00281-017-0662-9
   Nagele RG, 2011, J ALZHEIMERS DIS, V25, P605, DOI 10.3233/JAD-2011-110098
   Naseri NN, 2019, NEUROSCI LETT, V705, P183, DOI 10.1016/j.neulet.2019.04.022
   Nath A, 2003, NEUROMOL MED, V3, P29, DOI 10.1385/NMM:3:1:29
   Newcombe EA, 2018, J NEUROINFLAMM, V15, DOI 10.1186/s12974-018-1313-3
   Ng TP, 2014, J ALZHEIMERS DIS, V41, P61, DOI 10.3233/JAD-131901
   Nicoll JAR, 2000, ANN NEUROL, V47, P365, DOI 10.1002/1531-8249(200003)47:3<365::AID-ANA13>3.0.CO;2-G
   Nuzzo D, 2019, NEUROBIOL DIS, V121, P296, DOI 10.1016/j.nbd.2018.10.012
   O'Bryant SE, 2018, J ALZHEIMERS DIS, V66, P97, DOI 10.3233/JAD-180619
   O'Bryant SE, 2010, J GERIATR PSYCH NEUR, V23, P49, DOI 10.1177/0891988709351832
   Ofengeim D, 2017, P NATL ACAD SCI USA, V114, pE8788, DOI 10.1073/pnas.1714175114
   Onyango IG, 2021, CURR ALZHEIMER RES, V18, P753, DOI 10.2174/1567205018666211208125855
   Paffen E, 2006, CARDIOVASC RES, V71, P30, DOI 10.1016/j.cardiores.2006.03.004
   Palta P, 2021, NEUROBIOL AGING, V97, P89, DOI 10.1016/j.neurobiolaging.2020.09.023
   Perkovic MN, 2019, ADV EXP MED BIOL, V1192, P27, DOI 10.1007/978-981-32-9721-0_3
   Piché ME, 2020, CIRC RES, V126, P1477, DOI 10.1161/CIRCRESAHA.120.316101
   Prusiner SB, 2012, SCIENCE, V336, P1511, DOI 10.1126/science.1222951
   Pugazhenthi S, 2017, BBA-MOL BASIS DIS, V1863, P1037, DOI 10.1016/j.bbadis.2016.04.017
   Rao RV, 2012, ALZHEIMERS RES THER, V4, DOI 10.1186/alzrt125
   Ratushnyy AY, 2020, BIOCHEMISTRY-MOSCOW+, V85, P1169, DOI 10.1134/S0006297920100053
   Rea IM, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.00586
   Roher AE, 2011, ALZHEIMERS DEMENT, V7, P436, DOI 10.1016/j.jalz.2010.08.228
   Royce GH, 2019, GEROSCIENCE, V41, P795, DOI 10.1007/s11357-019-00131-w
   Ruas JL, 2005, SEMIN CELL DEV BIOL, V16, P514, DOI 10.1016/j.semcdb.2005.04.001
   Schenk S, 2008, J CLIN INVEST, V118, P2992, DOI 10.1172/JCI34260
   Schumacher J, 2022, BRAIN, V145, P1773, DOI 10.1093/brain/awab372
   Senatus LM, 2017, FRONT GENET, V8, DOI 10.3389/fgene.2017.00187
   Shao YP, 1997, J NEUROPATH EXP NEUR, V56, P376, DOI 10.1097/00005072-199704000-00006
   Sheedy FJ, 2013, NAT IMMUNOL, V14, P812, DOI 10.1038/ni.2639
   Shen YY, 2020, THERANOSTICS, V10, P11794, DOI 10.7150/thno.44152
   Shorter J, 2008, NEUROSIGNALS, V16, P63, DOI 10.1159/000109760
   Sierksma A, 2020, EMBO MOL MED, V12, DOI 10.15252/emmm.201910606
   Simon MS, 2021, PROG NEURO-PSYCHOPH, V111, DOI 10.1016/j.pnpbp.2021.110391
   Sivandzade F, 2019, REDOX BIOL, V21, DOI 10.1016/j.redox.2018.11.017
   Skulachev VP, 2009, BIOCHEMISTRY-MOSCOW+, V74, P1400, DOI 10.1134/S0006297909120165
   Slevin M, 2015, SCI REP-UK, V5, DOI 10.1038/srep13281
   Snowden MB, 2015, AM J GERIAT PSYCHIAT, V23, P897, DOI 10.1016/j.jagp.2014.09.002
   Soininen H, 2007, DEMENT GERIATR COGN, V23, P8, DOI 10.1159/000096588
   Sudheimer KD, 2014, FRONT AGING NEUROSCI, V6, DOI 10.3389/fnagi.2014.00153
   Taipa R, 2018, NEUROPATH APPL NEURO, V44, P298, DOI 10.1111/nan.12445
   Tan HW, 2010, ATHEROSCLEROSIS, V208, P350, DOI 10.1016/j.atherosclerosis.2009.07.053
   Thevaranjan N, 2017, CELL HOST MICROBE, V21, P455, DOI 10.1016/j.chom.2017.03.002
   Nguyen TT, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21093165
   Tilstra JS, 2012, J CLIN INVEST, V122, P2601, DOI 10.1172/JCI45785
   Trovato A, 2016, IMMUN AGEING, V13, DOI 10.1186/s12979-016-0078-8
   Tsai MC, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0188490
   Tumani H, 2018, HAND CLINIC, V146, P21, DOI 10.1016/B978-0-12-804279-3.00002-2
   Tumminia A, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19113306
   Tzeng NS, 2018, NEUROTHERAPEUTICS, V15, P417, DOI 10.1007/s13311-018-0611-x
   Urbanova B, 2014, FRONT BEHAV NEUROSCI, V8, DOI 10.3389/fnbeh.2014.00004
   Ushakova VM, 2019, ZH VYSSH NERV DEYAT+, V69, P230, DOI 10.1134/S0044467719020114
   Vadukul DM, 2020, FEBS LETT, V594, P3490, DOI 10.1002/1873-3468.13919
   Valerio A, 2006, EUR J NEUROSCI, V23, P1711, DOI 10.1111/j.1460-9568.2006.04722.x
   Vendredy L, 2020, CELL STRESS CHAPERON, V25, P679, DOI 10.1007/s12192-020-01101-4
   Voskobiynyk Y, 2020, ELIFE, V9, DOI 10.7554/eLife.57354
   Walker FR, 2013, NEUROPHARMACOLOGY, V67, P304, DOI 10.1016/j.neuropharm.2012.10.002
   Wang Yiwei, 2020, F1000Res, V9, DOI 10.12688/f1000research.21599.1
   Wegmann S, 2021, CURR OPIN NEUROBIOL, V69, P131, DOI 10.1016/j.conb.2021.03.003
   Westerterp M, 2018, CIRCULATION, V138, P898, DOI 10.1161/CIRCULATIONAHA.117.032636
   Willette AA, 2015, JAMA NEUROL, V72, P1013, DOI 10.1001/jamaneurol.2015.0613
   World Health Organization WHO, 2021, AG HLTH
   Wozniak MA, 2009, J PATHOL, V217, P131, DOI 10.1002/path.2449
   Xie JH, 2022, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.796867
   Xie JH, 2021, ACTA NEUROPATHOL COM, V9, DOI 10.1186/s40478-021-01253-z
   Yang C, 2014, BRAZ J MED BIOL RES, V47, P237, DOI 10.1590/1414-431X20133275
   Zhang CX, 2018, FRONT AGING NEUROSCI, V10, DOI 10.3389/fnagi.2018.00083
   Zhang F, 2019, ACS CHEM NEUROSCI, V10, P902, DOI 10.1021/acschemneuro.8b00442
   Zhang JY, 2017, DIABETES RES CLIN PR, V124, P41, DOI 10.1016/j.diabres.2016.10.024
   Zotova E, 2011, NEUROPATH APPL NEURO, V37, P513, DOI 10.1111/j.1365-2990.2010.01156.x
NR 207
TC 49
Z9 54
U1 3
U2 65
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3425
J9 BRAIN SCI
JI Brain Sci.
PD SEP
PY 2022
VL 12
IS 9
AR 1237
DI 10.3390/brainsci12091237
PG 24
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 4T5AU
UT WOS:000858130700001
PM 36138973
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Baye, E
   Naderpoor, N
   Misso, M
   Teede, H
   Moran, LJ
   de Courten, B
AF Baye, Estifanos
   Naderpoor, Negar
   Misso, Marie
   Teede, Helena
   Moran, Lisa J.
   de Courten, Barbora
TI Treatment with high dose salicylates improves cardiometabolic
   parameters: Meta-analysis of randomized controlled trials
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Salicylates; Type 2 diabetes; Cardiovascular disease; Chronic
   inflammation; Meta-analysis
ID TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE; ENDOTHELIAL DYSFUNCTION;
   SALSALATE TREATMENT; KAPPA-B; TARGETING INFLAMMATION; GLUCOSE-TOLERANCE;
   OXIDATIVE STRESS; ADIPOSE-TISSUE; ASPIRIN
AB Introduction. There is conflicting evidence regarding the efficacy of high dose salicylates in improving cardiometabolic risk in healthy and type 2 diabetes patients. We aimed to determine whether treatment with salicylates at an anti-inflammatory dose (>= 1 g daily) would improve cardiometabolic risk in healthy individuals and type 2 diabetes patients, compared to placebo.
   Methods. Medline, Medline-in-process, Embase, and all EBM databases were searched for studies published up to December 2016. Twenty-eight articles from 24 studies comprising 1591 participants were included. Two reviewers independently assessed the risk of bias and extracted data from included studies. Meta-analyses using random-effects model were used to analyze the data.
   Results. High dose salicylates (>= 3 g/d) decreased fasting glucose (MD -0.4 mmol/l, 95% CI -0.54, -0.27) and glucose area under the curve (MD -0.41 mmol/l, 95% CI -0.81, -0.01). Salicylates (>= 3 g/d) also increased fasting insulin (MD 2.4 mu U/ml, 95% CI 0.3, 4.4), 2-h insulin (MD 25.4 mu U/ml, 95% CI 8.2, 42.6), insulin secretion (MD 79.2, 95% CI 35, 173) but decreased fasting C-peptide (MD -0.11 nmol/l, 95% CI -0.2, -0.04), insulin clearance (MD -0.26 l/min, 95% CI -0.36, -0.16) and triglycerides (MD -0.36 mmol/l, 95% CI -0.51, -0.21) and increased total adiponectin (MD 1.97 mu g/ml, 95% CI 0.99, 2.95). A lower salicylate dose (1-2.9 g) did not change any cardiometabolic parameters (p > 0.1). No significant difference was observed between those receiving salicylates and placebo following withdrawal due to adverse events.
   Conclusions. High dose salicylates appear to improve cardiometabolic risk factors in healthy individuals and type 2 diabetes patients. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Baye, Estifanos; Naderpoor, Negar; Misso, Marie; Teede, Helena; Moran, Lisa J.; de Courten, Barbora] Monash Univ, Sch Publ Hlth & Prevent Med, Monash Ctr Hlth Res & Implementat, 43-51 Kanooka Grove, Clayton, Vic 3168, Australia.
   [Naderpoor, Negar; Teede, Helena; de Courten, Barbora] Monash Hlth, Diabet & Vasc Med Unit, Locked Bag 29, Clayton, Vic 3168, Australia.
C3 Monash University; Monash Health
RP de Courten, B (corresponding author), Monash Univ, Sch Publ Hlth & Prevent Med, Monash Ctr Hlth Res & Implementat, 43-51 Kanooka Grove, Clayton, Vic 3168, Australia.
EM barbora.decourten@monash.edu
RI Naderpoor, Negar/IUM-7706-2023; Moran, Lisa/E-9850-2015; de Courten,
   Barbora/B-3308-2012
OI Baye, Estifanos/0000-0002-2937-356X; de Courten,
   Barbora/0000-0001-8760-2511; Moran, Lisa/0000-0001-5772-6484; Naderpoor,
   Negar/0000-0002-1738-3189; Teede, Helena/0000-0001-7609-577X
FU Monash Graduate Scholarship; Monash International Postgraduate
   Scholarship; Australian Postgraduate Award by Monash University;
   National Heart Foundation Fellowship [100864]; South Australian
   Cardiovascular Research Development Program Fellowship [ID AC115374];
   National Heart Foundation; South Australian Department of Health; South
   Australian Health and Medical Research Institute
FX EB is a recipient of Monash Graduate Scholarship and Monash
   International Postgraduate Scholarship. NN is a recipient Australian
   Postgraduate Award provided by Monash University. HT is a National
   Health and Medical Research Council Fellow. BdC is supported by a
   National Heart Foundation Fellowship (100864). L.J.M. is supported by a
   South Australian Cardiovascular Research Development Program Fellowship
   (ID AC115374); a program collaboratively funded by the National Heart
   Foundation, the South Australian Department of Health and the South
   Australian Health and Medical Research Institute. We would like to thank
   Dr. Juraj Koska for his valuable feedback on the manuscript.
CR Alderete TL, 2015, OBESITY, V23, P543, DOI 10.1002/oby.20991
   [Anonymous], EV SYNTH POGR TEMPL
   [Anonymous], US PREVENTIVE SERVIC
   Ariel D, 2015, J CLIN LIPIDOL, V9, P658, DOI 10.1016/j.jacl.2015.06.009
   Barzilay JI, 2014, DIABETES CARE, V37, P1083, DOI 10.2337/dc13-1527
   Campbell RK, 2009, J AM PHARM ASSOC, V49, pS3, DOI 10.1331/JAPhA.2009.09077
   CAVIEZEL F, 1981, ACTA DIABETOL LAT, V18, P225, DOI 10.1007/BF02047894
   CHALMERS JP, 1984, CLIN EXP HYPERTENS A, V6, P1077, DOI 10.3109/10641968409039582
   Chiasson JL, 2002, LANCET, V359, P2072, DOI 10.1016/S0140-6736(02)08905-5
   DeFronzo RA, 2011, NEW ENGL J MED, V364, P1104, DOI 10.1056/NEJMoa1010949
   Din FVN, 2012, GASTROENTEROLOGY, V142, P1504, DOI 10.1053/j.gastro.2012.02.050
   Ewart MA, 2011, PHARMACOL THERAPEUT, V131, P242, DOI 10.1016/j.pharmthera.2010.11.002
   Faghihimani E, 2012, ENDOCR PRACT, V18, P826, DOI 10.4158/EP12064.OR
   Faghihimani E, 2013, ACTA DIABETOL, V50, P537, DOI 10.1007/s00592-011-0329-2
   Fakhri M, 2014, J RES MED SCI, V19, P287
   Fang F, 2013, J HUAZHONG U SCI-MED, V33, P1, DOI 10.1007/s11596-013-1063-5
   Fleischman A, 2008, DIABETES CARE, V31, P289, DOI 10.2337/dc07-1338
   Goldfine AB, 2013, DIABETOLOGIA, V56, P714, DOI 10.1007/s00125-012-2819-3
   Goldfine AB, 2013, DIABETES CARE, V36, P4132, DOI 10.2337/dc13-0859
   Goldfine AB, 2013, ANN INTERN MED, V159, P1, DOI 10.7326/0003-4819-159-1-201307020-00003
   Goldfine AB, 2010, ANN INTERN MED, V152, P346, DOI 10.7326/0003-4819-152-6-201003160-00004
   Goldfine AB, 2008, CTS-CLIN TRANSL SCI, V1, P36, DOI 10.1111/j.1752-8062.2008.00026.x
   Guirguis-Blake JM, 2016, ANN INTERN MED, V164, P804, DOI 10.7326/M15-2113
   Hauser TH, 2016, JAMA CARDIOL, V1, P413, DOI 10.1001/jamacardio.2016.0605
   Hawley SA, 2012, SCIENCE, V336, P918, DOI 10.1126/science.1215327
   Hennekens CH, 2013, AM J MED, V126, P373, DOI 10.1016/j.amjmed.2012.12.013
   Khajehdehi P, 2002, SCAND J UROL NEPHROL, V36, P145, DOI 10.1080/003655902753679454
   Khamzina L, 2005, ENDOCRINOLOGY, V146, P1473, DOI 10.1210/en.2004-0921
   Kharbanda RK, 2002, CIRCULATION, V105, P2600, DOI 10.1161/01.CIR.0000017863.52347.6C
   Kim SH, 2014, DIABETES CARE, V37, P1944, DOI 10.2337/dc13-2977
   Knowler William C, 2002, N Engl J Med, V346, P393, DOI 10.1056/NEJMoa012512
   KOPP E, 1994, SCIENCE, V265, P956, DOI 10.1126/science.8052854
   Koska J, 2009, DIABETOLOGIA, V52, P385, DOI 10.1007/s00125-008-1239-x
   Le Bacquer O, 2013, J ENDOCRINOL, V216, P21, DOI 10.1530/JOE-12-0351
   Lexis CPH, 2015, BMJ OPEN DIAB RES CA, V3, DOI [10.1136/bmjdrc-2015-000090, 10.1136/bmjdrc-2015000090]
   Liu X, 2014, PHARMACOEPIDEM DR S, V23, P687, DOI 10.1002/pds.3586
   Maruthur NM, 2013, J GEN INTERN MED, V28, P1629, DOI 10.1007/s11606-013-2548-4
   MIELANTS H, 1981, SCAND J RHEUMATOL, V10, P169, DOI 10.3109/03009748109095292
   MILLS EH, 1982, AUST NZ J MED, V12, P478, DOI 10.1111/j.1445-5994.1982.tb03826.x
   Mora MEV, 2003, J AM COLL NUTR, V22, P487, DOI 10.1080/07315724.2003.10719326
   Nixon M, 2012, DIABETES, V61, P790, DOI 10.2337/db11-0931
   Nohria A, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.113.000609
   Nyenwe EA, 2011, METABOLISM, V60, P1, DOI 10.1016/j.metabol.2010.09.010
   Penesova A, 2015, DIABETES OBES METAB, V17, P608, DOI 10.1111/dom.12450
   Pierce GL, 2009, CIRCULATION, V119, P1284, DOI 10.1161/CIRCULATIONAHA.108.804294
   Preiss D, 2014, LANCET DIABETES ENDO, V2, P116, DOI 10.1016/S2213-8587(13)70152-9
   Rachmani R, 2004, DIABETES OBES METAB, V6, P63, DOI 10.1111/j.1463-1326.2004.00317.x
   Raghavan RP, 2014, INT J CLIN PRACT, V68, P271, DOI 10.1111/ijcp.12310
   Rumore MM, 2010, ANN PHARMACOTHER, V44, P1207, DOI 10.1345/aph.1M483
   Salpeter SR, 2008, AM J MED, V121, P149, DOI 10.1016/j.amjmed.2007.09.016
   Shehzad A, 2012, HORM-INT J ENDOCRINO, V11, P8, DOI 10.1007/BF03401534
   Sherifali D, 2010, DIABETES CARE, V33, P1859, DOI 10.2337/dc09-1727
   Tarantino G, 2013, ANN MED, V45, P348, DOI 10.3109/07853890.2013.770333
   Vlachopoulos C, 2015, INT J CARDIOL, V189, P293, DOI 10.1016/j.ijcard.2015.04.029
   Wagner JA, 2009, CLIN PHARMACOL THER, V86, P619, DOI 10.1038/clpt.2009.88
   Walker AE, 2014, CLIN SCI, V127, P645, DOI 10.1042/CS20140030
   WALTER E, 1981, KLIN WOCHENSCHR, V59, P297, DOI 10.1007/BF01478209
   Yin MJ, 1998, NATURE, V396, P77, DOI 10.1038/23948
   Zu LX, 2008, MOL PHARMACOL, V73, P215, DOI 10.1124/mol.107.039479
NR 59
TC 4
Z9 5
U1 0
U2 4
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUN
PY 2017
VL 71
BP 94
EP 106
DI 10.1016/j.metabol.2017.03.006
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EW5YW
UT WOS:000402583400010
PM 28521883
DA 2025-06-11
ER

PT J
AU Pelletier, JR
   Nguyen, M
   Bradley, K
   Johnsen, M
   McKay, C
AF Pelletier, JR
   Nguyen, M
   Bradley, K
   Johnsen, M
   McKay, C
TI A study of a structured exercise program with members of an ICCD
   certified clubhouse: Program design, benefits, and implications for
   feasibility
SO PSYCHIATRIC REHABILITATION JOURNAL
LA English
DT Article
ID PSYCHIATRIC-DISORDERS; METABOLIC SYNDROME; MORTALITY; HEALTH;
   PREVALENCE; OBESITY; ADULTS; RISK
AB Individuals with serious mental illness (SMI) have significantly greater risk of co-morbid health problems and premature death, and there is need for interventions that can improve physical fitness and overall health. Accordingly, a study was conducted which evaluated the effectiveness of a structured physical exercise program that was developed as part of a wellness project in an ICCD Certified Clubhouse. Seventeen clubhouse members completed a 16-week program with evidence of significant improvement in aerobic capacity and perceived mental health as well as positive trends in perceived improvements in physical and social functioning. Qualitative data indicated satisfaction with the program by all participants, especially the value of group support, while also highlighting the need for greater attention to nutrition as part of a future program. Moreover, the study found that a structured exercise program can be successfully provided to members of an ICCD Certified Clubhouse.
C1 Assumption Coll, Inst Social & Rehab Serv, Worcester, MA 01609 USA.
   Univ Massachusetts, Sch Med, Ctr Mental Htlh Serv Res, Program Clubhouse Res, Amherst, MA 01003 USA.
C3 Assumption College; University of Massachusetts System; University of
   Massachusetts Amherst
RP Assumption Coll, Inst Social & Rehab Serv, 500 Salibury St, Worcester, MA 01609 USA.
EM jpelleti@assumption.edu
RI McKay, Colleen/LMN-3770-2024
OI McKay, Colleen/0000-0001-8578-6222
CR Bassett SS, 1998, PSYCHOL MED, V28, P509, DOI 10.1017/S0033291798006606
   Beard J.H., 1982, PSYCHOSOC REHABIL J, V5, P47
   BERREN MR, 1994, HOSP COMMUNITY PSYCH, V45, P604
   Brosse AL, 2002, SPORTS MED, V32, P741, DOI 10.2165/00007256-200232120-00001
   *COMM MASS EX OFF, 2001, MORT REP 1998 1999
   *DEP MENT HLTH CEN, 2001, MORB STUD MED ILLN C
   Dixon L, 2001, J NERV MENT DIS, V189, P17, DOI 10.1097/00005053-200101000-00004
   Fontaine KR, 2003, JAMA-J AM MED ASSOC, V289, P187, DOI 10.1001/jama.289.2.187
   Fox KR, 1999, PUBLIC HEALTH NUTR, V2, P411, DOI 10.1017/S1368980099000567
   Hutchinson DS, 1999, PSYCHIATR REHABIL J, V22, P355, DOI 10.1037/h0095215
   Kornegay CJ, 2002, J CLIN PSYCHIAT, V63, P758, DOI 10.4088/JCP.v63n0902
   Kriska A M, 1994, Exerc Sport Sci Rev, V22, P121
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lindenmayer JP, 2001, J CLIN PSYCHIAT, V62, P30
   Meyer T, 2000, SPORTS MED, V30, P269, DOI 10.2165/00007256-200030040-00003
   Mittal VA, 2011, PSYCHIAT RES, V189, P158, DOI 10.1016/j.psychres.2011.06.006
   Mokdad AH, 2003, JAMA-J AM MED ASSOC, V289, P76, DOI 10.1001/jama.289.1.76
   MURPHY JM, 1989, SOC PSYCH PSYCH EPID, V24, P134, DOI 10.1007/BF01788022
   Plante T G, 1996, J Psychosoc Nurs Ment Health Serv, V34, P38
   Prior P, 1996, J PUBLIC HEALTH MED, V18, P381, DOI 10.1093/oxfordjournals.pubmed.a024534
   Propst R N, 1997, New Dir Ment Health Serv, P53
   Putnam M, 2003, J REHABIL, V69, P37
   Ryan MCM, 2002, LIFE SCI, V71, P239, DOI 10.1016/S0024-3205(02)01646-6
   SIEGEL W C, 1991, Annals of Behavioral Medicine, V13, P23
   Spring B, 2003, AM J PSYCHIAT, V160, P316, DOI 10.1176/appi.ajp.160.2.316
   Stahl SM, 2002, J CLIN PSYCHIAT, V63, P1094, DOI 10.4088/JCP.v63n1201
   Weil E, 2002, JAMA-J AM MED ASSOC, V288, P1265, DOI 10.1001/jama.288.10.1265
   WOOD PD, 1988, NEW ENGL J MED, V319, P1173, DOI 10.1056/NEJM198811033191801
NR 28
TC 23
Z9 33
U1 0
U2 5
PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA
SN 1095-158X
EI 1559-3126
J9 PSYCHIATR REHABIL J
JI Psychiatr. Rehabil. J.
PD FAL
PY 2005
VL 29
IS 2
BP 89
EP 96
DI 10.2975/29.2005.89.96
PG 8
WC Psychiatry; Rehabilitation
WE Social Science Citation Index (SSCI)
SC Psychiatry; Rehabilitation
GA 974JT
UT WOS:000232588400002
PM 16268003
DA 2025-06-11
ER

PT J
AU Alves, FCR
   Moreira, A
   Moutinho, O
AF Alves, Fernanda Cristina Ribeiro
   Moreira, Ana
   Moutinho, Osvaldo
TI Maternal and long-term offspring outcomes of obesity during pregnancy
SO ARCHIVES OF GYNECOLOGY AND OBSTETRICS
LA English
DT Review
DE Pregnancy; Maternal obesity; Risk management; Offspring
ID BODY-MASS INDEX; GESTATIONAL WEIGHT-GAIN; BARIATRIC SURGERY;
   PHYSICAL-ACTIVITY; INTERNATIONAL FEDERATION; NONCOMMUNICABLE DISEASES;
   CESAREAN DELIVERY; PREPREGNANCY BMI; FIGO PREGNANCY; POSITION PAPER
AB PurposeObesity`s prevalence is rising in women of reproductive age worldwide and has become the most common medical condition at this age group. Besides, its occurrence is also rising during pregnancy. This condition not only increases the risk of noncommunicable diseases on the mother, such as cardiovascular disease and diabetes, but also transfers this risk to the offspring.MethodsThis is a narrative review based on scientific and review articles on the matter.ResultsObesity is associated with an increased risk of gestational diabetes mellitus, gestational hypertension and preeclampsia, venous thromboembolism, infection, and mental health problems. Furthermore, it has an impact on the progress of labor and induction matters. Regarding offspring outcomes, it is related to higher incidence of congenital anomalies, perinatal mortality, and the occurrence of large for gestational age newborns. Still, it has implications on cardiometabolic risk and neurodevelopment in offspring.ConclusionIt is, therefore, imperative to encourage the adoption of healthy lifestyles, especially in the peri-conception and interpregnancy periods. Likewise, there must be support in the multidisciplinary monitoring of these pregnant women to minimize associated complication rates.
C1 [Alves, Fernanda Cristina Ribeiro; Moreira, Ana; Moutinho, Osvaldo] Ctr Hosp Tras Os Montes & Alto Douro, Obstet & Gynecol Dept, Ave Noruega, Vila Real, Portugal.
RP Alves, FCR (corresponding author), Ctr Hosp Tras Os Montes & Alto Douro, Obstet & Gynecol Dept, Ave Noruega, Vila Real, Portugal.
EM alves.fcr@sapo.pt
CR Akhter Z, 2019, PLOS MED, V16, DOI 10.1371/journal.pmed.1002866
   [Anonymous], 2020, Obstet Gynecol, V135, pe178, DOI 10.1097/AOG.0000000000003772
   [Anonymous], 2010, WEIGHT MANAGEMENT PR
   Association of Anaesthetists of Great Britain and Ireland and Obstetrics Anaesthetists Association, 2013, OAAAAGBI GUIDELINES
   Aune D, 2014, JAMA-J AM MED ASSOC, V311, P1536, DOI 10.1001/jama.2014.2269
   Barakat R, 2012, J MATERN-FETAL NEO M, V25, P2372, DOI 10.3109/14767058.2012.696165
   Bedell S, 2021, CURR VASC PHARMACOL, V19, P176, DOI 10.2174/1570161118666200616144512
   Blondon M, 2016, THROMB RES, V145, P151, DOI 10.1016/j.thromres.2016.06.026
   Bodnar LM, 2005, AM J EPIDEMIOL, V162, P1198, DOI 10.1093/aje/kwi334
   Boller MJ, 2023, OBSTET GYNECOL, V141, P583, DOI 10.1097/AOG.0000000000005088
   Buhimschi CS, 2004, OBSTET GYNECOL, V103, P225, DOI 10.1097/01.AOG.000102706.84063.C7
   Catalano PM, 2017, BMJ-BRIT MED J, V356, DOI 10.1136/bmj.j1
   Catalano PM, 2003, J NUTR, V133, p1674S, DOI 10.1093/jn/133.5.1674S
   Cnattingius S, 2013, JAMA-J AM MED ASSOC, V309, P2362, DOI 10.1001/jama.2013.6295
   D'Souza R, 2019, AM J OBST GYNEC MFM, V1, DOI 10.1016/j.ajogmf.2019.100041
   Delhaes F, 2018, PLACENTA, V69, P118, DOI 10.1016/j.placenta.2018.05.011
   Denison FC, 2019, BJOG-INT J OBSTET GY, V126, pE62, DOI 10.1111/1471-0528.15386
   Dye TD, 1997, AM J EPIDEMIOL, V146, P961, DOI 10.1093/oxfordjournals.aje.a009223
   Edlow AG, 2017, PRENATAL DIAG, V37, P95, DOI 10.1002/pd.4932
   Ehrenberg HM, 2002, AM J OBSTET GYNECOL, V187, P1189, DOI 10.1067/mob.2002.127125
   Fleming TP, 2018, LANCET, V391, P1842, DOI [10.1016/S0140-6736(18)30312-X, 10.1016/s0140-6736(18)30312-x]
   Forno E, 2014, PEDIATRICS, V134, pE535, DOI 10.1542/peds.2014-0439
   Getahun D, 2022, AM J OBSTET GYNECOL, V226, DOI 10.1016/j.ajog.2021.06.087
   Godfrey KM, 2017, LANCET DIABETES ENDO, V5, P53, DOI 10.1016/S2213-8587(16)30107-3
   GROSS T, 1980, OBSTET GYNECOL, V56, P446
   Guelinckx I, 2009, HUM REPROD UPDATE, V15, P189, DOI 10.1093/humupd/dmn057
   Guh Daphne P, 2009, BMC Public Health, V9, P88, DOI 10.1186/1471-2458-9-88
   Hanson M, 2019, INT J GYNECOL OBSTET, V147, P131, DOI 10.1002/ijgo.12950
   Hanson MA, 2015, INT J GYNECOL OBSTET, V131, pS213, DOI 10.1016/S0020-7292(15)30034-5
   Heslehurst N, 2008, OBES REV, V9, P635, DOI 10.1111/j.1467-789X.2008.00511.x
   Heslehurst N, 2007, BJOG-INT J OBSTET GY, V114, P334, DOI 10.1111/j.1471-0528.2006.01230.x
   Hibbard JU, 2006, OBSTET GYNECOL, V108, P125, DOI 10.1097/01.AOG.0000223871.69852.31
   Jacob CM, 2020, INT J GYNECOL OBSTET, V151, P6, DOI 10.1002/ijgo.13331
   Kanagalingam MG, 2005, BJOG-INT J OBSTET GY, V112, P1431, DOI 10.1111/j.1471-0528.2005.00685.x
   Karmon A, 2008, ARCH GYNECOL OBSTET, V277, P381, DOI 10.1007/s00404-008-0608-5
   Kevane B, 2014, J PERINAT MED, V42, P417, DOI 10.1515/jpm-2013-0207
   Kislal S, 2020, PRENATAL DIAG, V40, P1109, DOI 10.1002/pd.5784
   Kolomanska-Bogucka D, 2019, MEDICINA-LITHUANIA, V55, DOI 10.3390/medicina55090560
   Kominiarek MA, 2011, AM J OBSTET GYNECOL, V205, DOI 10.1016/j.ajog.2011.06.014
   Kwong W, 2018, AM J OBSTET GYNECOL, V218, P573, DOI 10.1016/j.ajog.2018.02.003
   LaCoursiere DY, 2005, AM J OBSTET GYNECOL, V192, P832, DOI 10.1016/j.ajog.2004.11.034
   Lisonkova S, 2017, JAMA-J AM MED ASSOC, V318, P1777, DOI 10.1001/jama.2017.16191
   Lockwood CJ, 2013, AM J PATHOL, V183, P841, DOI 10.1016/j.ajpath.2013.05.029
   Maggard MA, 2008, JAMA-J AM MED ASSOC, V300, P2286, DOI 10.1001/jama.2008.641
   Magro-Malosso ER, 2017, ACTA OBSTET GYN SCAN, V96, P921, DOI 10.1111/aogs.13151
   Maxwell C, 2019, J OBSTET GYNAECOL CA, V41, P1623, DOI 10.1016/j.jogc.2019.03.026
   McAuliffe FM, 2020, INT J GYNECOL OBSTET, V151, P16, DOI 10.1002/ijgo.13334
   McDonald Sarah D, 2010, BMJ, V341, pc3428, DOI 10.1136/bmj.c3428
   Metzger BE, 2010, BJOG-INT J OBSTET GY, V117, P575, DOI 10.1111/j.1471-0528.2009.02486.x
   Molyneaux E, 2014, OBSTET GYNECOL, V123, P857, DOI 10.1097/AOG.0000000000000170
   Moos MK, 2008, AM J OBSTET GYNECOL, V199, pS280, DOI 10.1016/j.ajog.2008.08.060
   Nakamura A, 2019, J AFFECT DISORDERS, V246, P29, DOI 10.1016/j.jad.2018.12.009
   Nuthalapaty FS, 2004, OBSTET GYNECOL, V103, P452
   O'Brien TE, 2003, EPIDEMIOLOGY, V14, P368, DOI 10.1097/00001648-200305000-00020
   Owens Lisa A, 2010, Diabetes Care, V33, P577, DOI 10.2337/dc09-0911
   Pfeifer S, 2015, FERTIL STERIL, V104, P1116, DOI 10.1016/j.fertnstert.2015.08.018
   Polnaszek BE, 2018, OBSTET GYNECOL, V132, P835, DOI 10.1097/AOG.0000000000002775
   Poston L, 2016, LANCET DIABETES ENDO, V4, P1025, DOI 10.1016/S2213-8587(16)30217-0
   Pritchard NL, 2023, AM J OBSTET GYNECOL, V229, p59e1, DOI 10.1016/j.ajog.2022.12.322
   Ramsay JE, 2002, J CLIN ENDOCR METAB, V87, P4231, DOI 10.1210/jc.2002-020311
   Reynolds RM, 2013, BMJ-BRIT MED J, V347, DOI 10.1136/bmj.f4539
   Rives-Lange C, 2023, JAMA SURG, V158, P36, DOI 10.1001/jamasurg.2022.5450
   Robinson HE, 2005, OBSTET GYNECOL, V106, P1357, DOI 10.1097/01.AOG.0000188387.88032.41
   Santos S, 2019, BJOG-INT J OBSTET GY, V126, P984, DOI 10.1111/1471-0528.15661
   Santry HP, 2005, JAMA-J AM MED ASSOC, V294, P1909, DOI 10.1001/jama.294.15.1909
   Scialli AR, 2006, BIRTH DEFECTS RES A, V76, P73, DOI 10.1002/bdra.20236
   Sebire NJ, 2001, INT J OBESITY, V25, P1175, DOI 10.1038/sj.ijo.0801670
   Stothard KJ, 2009, JAMA-J AM MED ASSOC, V301, P636, DOI 10.1001/jama.2009.113
   Teefey CP, 2020, OBSTET GYNECOL, V135, P542, DOI 10.1097/AOG.0000000000003703
   Torloni MR, 2009, OBES REV, V10, P194, DOI 10.1111/j.1467-789X.2008.00541.x
   Vahratian A, 2004, OBSTET GYNECOL, V104, P943, DOI 10.1097/01.AOG.0000142713.53197.91
   Ward ZJ, 2019, NEW ENGL J MED, V381, P2440, DOI 10.1056/NEJMsa1909301
   Weiss JL, 2004, AM J OBSTET GYNECOL, V190, P1091, DOI 10.1016/j.ajog.2003.09.058
   Wolf M, 2001, OBSTET GYNECOL, V98, P757, DOI 10.1016/S0029-7844(01)01551-4
   Wolfe KB, 2011, AM J OBSTET GYNECOL, V205, DOI 10.1016/j.ajog.2011.03.051
   World Health Organization, 2000, World Health Organ Tech Rep Ser, DOI DOI 10.1596/0-1952-1129-4
   Yang SY, 2021, EUR J OBSTET GYN R B, V264, P117, DOI 10.1016/j.ejogrb.2021.07.006
   Zhou B, 2016, LANCET, V387, P1513, DOI 10.1016/S0140-6736(16)00618-8
NR 78
TC 11
Z9 11
U1 1
U2 5
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0932-0067
EI 1432-0711
J9 ARCH GYNECOL OBSTET
JI Arch. Gynecol. Obstet.
PD JUN
PY 2024
VL 309
IS 6
BP 2315
EP 2321
DI 10.1007/s00404-023-07349-2
EA MAR 2024
PG 7
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA SZ4S9
UT WOS:001187476300006
PM 38502190
DA 2025-06-11
ER

PT J
AU Priftis, N
   Panagiotakos, D
AF Priftis, Nikos
   Panagiotakos, Demosthenes
TI Screen Time and Its Health Consequences in Children and Adolescents
SO CHILDREN-BASEL
LA English
DT Review
DE screen time; digital media; children; adolescents; review
ID SLEEP; DISORDER; EXPOSURE; OBESITY; HABITS
AB Nowadays, children and adolescents are exposed to digital media (DM) from an early age. Therefore, specific guidelines have been published by the World Health Organization, whose aim is to limit daily screen time (ST) viewing. However, during the COVID-19 pandemic, a rise in DM use, and consequently ST viewing, was observed. More and more aspects of modern life are thought to be affected by excessive ST viewing. Accordingly, the aim of this review is to document the health effects of excessive ST viewing on children and adolescents. A narrative review was performed in searchable databases. In total, 43 original articles were considered. Excessive ST viewing was correlated with increased risk for obesity and other cardiometabolic risk factors, mental health, unhealthy dietary habits and eating disorders, and problems in development and child-parent relationships. Sleep, physical activity, eyesight, headaches, and the musculoskeletal system were negatively affected as well. However, the effect of ST was weighted by the type of media used and the way types of media were used. Other confounding factors were reported. There is evidence to suggest a negative correlation between excessive ST and youth health exists. Nevertheless, more research is needed if this correlation is to be established.
C1 [Priftis, Nikos] Natl & Kapodistrian Univ Athens, Sch Med, Athens 11527, Greece.
   [Panagiotakos, Demosthenes] Harokopio Univ, Sch Hlth Sci & Educ, Athens 17671, Greece.
C3 Athens Medical School; National & Kapodistrian University of Athens;
   Harokopio University Athens
RP Panagiotakos, D (corresponding author), Harokopio Univ, Sch Hlth Sci & Educ, Athens 17671, Greece.
EM nk.priftis84@gmail.com; dbpanag@hua.gr
RI Panagiotakos, Demosthenes/K-8294-2019
OI Priftis, Nikos/0009-0003-7575-4974
CR [Anonymous], 1995, Bull World Health Organ, V73, P135
   Attygalle UR, 2020, BMC NEUROL, V20, DOI 10.1186/s12883-020-01855-5
   Azevedo N, 2023, EUR SPINE J, V32, P3280, DOI 10.1007/s00586-023-07751-z
   Bellissimo N, 2007, PEDIATR RES, V61, P745, DOI 10.1203/pdr.0b013e3180536591
   Bozzola E, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19169960
   Chang AM, 2015, P NATL ACAD SCI USA, V112, P1232, DOI 10.1073/pnas.1418490112
   Chong SC, 2023, PEDIATR RES, V94, P915, DOI 10.1038/s41390-023-02555-9
   Cureau FV, 2017, INT J OBESITY, V41, P551, DOI 10.1038/ijo.2016.210
   Dahlgren A, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0254255
   DIETZ WH, 1985, PEDIATRICS, V75, P807
   Dou QF, 2023, ENVIRON HEALTH PREV, V28, DOI 10.1265/ehpm.22-00243
   Dy ABC, 2023, BMC PUBLIC HEALTH, V23, DOI 10.1186/s12889-023-16188-4
   Edelson LR, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-2791-9
   Exelmans L, 2017, J SLEEP RES, V26, P364, DOI 10.1111/jsr.12510
   Fang KH, 2019, CHILD CARE HLTH DEV, V45, P744, DOI 10.1111/cch.12701
   Foreman J, 2021, LANCET DIGIT HEALTH, V3, pE806, DOI 10.1016/S2589-7500(21)00135-7
   Haghjoo P, 2022, BMC PRIM CARE, V23, DOI 10.1186/s12875-022-01761-4
   Hardy LL, 2018, J PHYS ACT HEALTH, V15, P933, DOI 10.1123/jpah.2017-0620
   Heffler KF, 2020, JAMA PEDIATR, V174, P690, DOI 10.1001/jamapediatrics.2020.0230
   Helgadottir B, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124467
   Higuchi S, 2005, J SLEEP RES, V14, P267, DOI 10.1111/j.1365-2869.2005.00463.x
   Hilty DM, 2023, BJPSYCH OPEN, V9, DOI 10.1192/bjo.2023.523
   Himebaugh NL, 2009, OPTOMETRY VISION SCI, V86, P106, DOI 10.1097/OPX.0b013e318194e962
   Hinten AE, 2023, CHILDREN-BASEL, V10, DOI 10.3390/children10010028
   Hokby Sebastian, 2023, Int J Environ Res Public Health, V20, DOI 10.3390/ijerph20043771
   Jago R, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2015-010355
   Jain Shilpa, 2023, Int J Environ Res Public Health, V20, DOI 10.3390/ijerph20043449
   John A, 2018, J MED INTERNET RES, V20, DOI 10.2196/jmir.9044
   Kahn M, 2021, EUR CHILD ADOLES PSY, V30, P1793, DOI 10.1007/s00787-020-01654-w
   Kaur K, 2022, OPHTHALMOL THER, V11, P1655, DOI 10.1007/s40123-022-00540-9
   Kerai S, 2022, BMC PUBLIC HEALTH, V22, DOI 10.1186/s12889-022-12701-3
   Khajeheian D, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15071343
   Kjellenberg K, 2021, CHILDREN-BASEL, V8, DOI 10.3390/children8110998
   Lin LY, 2015, INFANT BEHAV DEV, V38, P20, DOI 10.1016/j.infbeh.2014.12.005
   Lin WH, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0230242
   Lin YM, 2022, FRONT PEDIATR, V10, DOI 10.3389/fped.2022.987523
   Liu ML, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19095164
   Lonergan AR, 2020, INT J EAT DISORDER, V53, P485, DOI 10.1002/eat.23256
   Lund J, 2022, NEUROPEDIATRICS, V53, P221, DOI 10.1055/s-0041-1740550
   Madigan S, 2022, JAMA PEDIATR, V176, P1188, DOI 10.1001/jamapediatrics.2022.4116
   Madigan S, 2020, JAMA PEDIATR, V174, P665, DOI 10.1001/jamapediatrics.2020.0327
   Mahdavi SB, 2022, HEALTH PROMOT PERSPE, V12, P240, DOI 10.34172/hpp.2022.31
   Manwell LA, 2022, J INTEGR NEUROSCI, V21, DOI 10.31083/j.jin2101028
   Marin-Dragu S, 2023, PSYCHIAT RES, V326, DOI 10.1016/j.psychres.2023.115298
   Mineshita Y, 2021, BMC PUBLIC HEALTH, V21, DOI 10.1186/s12889-021-10484-7
   Mohamed MAS, 2022, CHILDREN-BASEL, V9, DOI 10.3390/children9121975
   Montagni I, 2016, CEPHALALGIA, V36, P1020, DOI 10.1177/0333102415620286
   Moon JH, 2019, ACTA PAEDIATR, V108, P903, DOI 10.1111/apa.14623
   Mougharbel F, 2020, CURR OBES REP, V9, P493, DOI 10.1007/s13679-020-00401-1
   Myers LJ, 2017, DEVELOPMENTAL SCI, V20, DOI 10.1111/desc.12430
   Nightingale CM, 2017, ARCH DIS CHILD, V102, P612, DOI 10.1136/archdischild-2016-312016
   Pagani LS, 2013, PEDIATR RES, V74, P350, DOI 10.1038/pr.2013.105
   Pedersen J, 2021, SCAND J PUBLIC HEALT, V49, P495, DOI 10.1177/1403494820914823
   Ponti M, 2023, PAED CHILD HEALT-CAN, V28, P184, DOI 10.1093/pch/pxac125
   Rocha LL, 2021, J ACAD NUTR DIET, V121, P1136, DOI 10.1016/j.jand.2020.12.010
   Rodrigo-Yanguas M, 2022, FRONT PSYCHIATRY, V13, DOI 10.3389/fpsyt.2022.798480
   Russell SJ, 2019, OBES REV, V20, P554, DOI 10.1111/obr.12812
   Sajeev MF, 2021, BRIT J ANAESTH, V127, P608, DOI 10.1016/j.bja.2021.06.039
   Schwarzfischer P, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0229708
   Sina E, 2021, INT J BEHAV NUTR PHY, V18, DOI 10.1186/s12966-021-01186-9
   Stiglic N, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-023191
   Sugiyama M, 2023, JAMA PEDIATR, V177, P303, DOI 10.1001/jamapediatrics.2022.5356
   Tamana SK, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0213995
   Tambalis KD, 2020, CENT EUR J PUBL HEAL, V28, P260, DOI 10.21101/cejph.a6097
   Tandon PS, 2021, JAMA NETW OPEN, V4, DOI 10.1001/jamanetworkopen.2021.27892
   Tremblay MS, 2011, INT J BEHAV NUTR PHY, V8, DOI 10.1186/1479-5868-8-98
   Vanderloo LM, 2020, PREV MED REP, V20, DOI 10.1016/j.pmedr.2020.101183
   Wilksch SM, 2020, INT J EAT DISORDER, V53, P96, DOI 10.1002/eat.23198
   Zhang G, 2016, EUR J PUBLIC HEALTH, V26, P13, DOI 10.1093/eurpub/ckv213
   Zhu R, 2020, PUBLIC HEALTH, V186, P204, DOI 10.1016/j.puhe.2020.07.028
   Zhu YL, 2022, FRONT PSYCHOL, V13, DOI 10.3389/fpsyg.2022.885819
   Zink J, 2019, PREV MED REP, V13, P281, DOI 10.1016/j.pmedr.2019.01.014
NR 72
TC 21
Z9 21
U1 15
U2 51
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9067
J9 CHILDREN-BASEL
JI Children-Basel
PD OCT
PY 2023
VL 10
IS 10
AR 1665
DI 10.3390/children10101665
PG 17
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA W8OD5
UT WOS:001094157500001
PM 37892328
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Leite, CE
   Mocelin, CA
   Petersen, GO
   Leal, MB
   Thiesen, FV
AF Leite, Carlos E.
   Mocelin, Clei A.
   Petersen, Guilherme O.
   Leal, Mirna B.
   Thiesen, Flavia V.
TI Rimonabant: an antagonist drug of the endocannabinoid system for the
   treatment of obesity
SO PHARMACOLOGICAL REPORTS
LA English
DT Review
DE endocannabinoids; obesity; rimonabant; psychiatric alterations
ID CARDIOMETABOLIC RISK-FACTORS; CANNABINOID-1 RECEPTOR BLOCKER; OVERWEIGHT
   PATIENTS; FOOD-INTAKE; WEIGHT; EFFICACY; SAFETY; MODULATION
AB Obesity, an ever-increasing problem in the industrialized world, has long been a target of research for a cure or, at least, control of its expansion. In the search for treatment, the recently discovered endocannabinoid system has emerged as a new target for controlling obesity and its associated conditions. The endocannabinoid system plays an important role in controlling weight and energy balance in humans. This system is activated to a greater extent in obese patients, and the specific blockage of its receptors is the aim of rimonabant, one of the most recent drugs created for the treatment of obesity. This drug acts as a blockade for endocannabinoid receptors found in the brain and peripheral organs that play an important role on carbohydrate and fat metabolism. Clinical studies have confirmed that, when used in combination with a low calorie diet, rimonabant promotes loss in body weight, loss in abdominal circumference, and improvements in dyslipidemia. Rimonabant is also being tested as a potential anti-smoking treatment since endocannabinoids are related to the pleasurable effect of nicotine. Thus, rimonabant constitutes a new therapeutic approach to obesity and cardiovascular risk factors. Studies show effectiveness in weight loss; however, side effects such as psychiatric alterations have been reported, including depression and anxiety. These side effects have led the FDA (Food and Drug Administration) to not approve this drug in the United States. For a more complete evaluation on the safety of this drug, additional studies are in progress.
C1 [Leite, Carlos E.; Petersen, Guilherme O.; Thiesen, Flavia V.] Pontificia Univ Catolica Rio Grande do Sul, Inst Toxicol, BR-90619900 Porto Alegre, RS, Brazil.
   [Mocelin, Clei A.; Petersen, Guilherme O.; Thiesen, Flavia V.] Pontificia Univ Catolica Rio Grande do Sul, Fac Pharm, BR-90619900 Porto Alegre, RS, Brazil.
   [Leal, Mirna B.] Pontificia Univ Catolica Rio Grande do Sul, Dept Pharmacol, BR-90619900 Porto Alegre, RS, Brazil.
C3 Pontificia Universidade Catolica Do Rio Grande Do Sul; Pontificia
   Universidade Catolica Do Rio Grande Do Sul; Pontificia Universidade
   Catolica Do Rio Grande Do Sul
RP Thiesen, FV (corresponding author), Pontificia Univ Catolica Rio Grande do Sul, Inst Toxicol, Av Ipiranga 6681,Predio 12,Bloco D,Sala 140, BR-90619900 Porto Alegre, RS, Brazil.
EM fvthiesen@pucrs.br
RI Leal, Mirna/A-9704-2017; Leite, Carlos Eduardo/U-4395-2017; Herrmann,
   Ana P/F-3694-2011; thiesen, flavia/A-3470-2017
OI Leite, Carlos Eduardo/0000-0002-6845-1612; Herrmann, Ana
   P/0000-0002-0330-0741; thiesen, flavia/0000-0003-4907-6789
CR [Anonymous], REV BRASILEIRA NUTR
   Aronne LJ, 2007, CLIN PHARMACOL THER, V81, P748, DOI 10.1038/sj.clpt.6100163
   Astrup A, 2008, LANCET, V371, P556, DOI 10.1016/S0140-6736(08)60263-9
   Christensen R, 2007, LANCET, V370, P1706, DOI 10.1016/S0140-6736(07)61721-8
   Cota D, 2003, J CLIN INVEST, V112, P423, DOI 10.1172/JCI17725
   Crespo I, 2008, NEUROPHARMACOLOGY, V54, P219, DOI 10.1016/j.neuropharm.2007.05.027
   Godoy-Matos Amélio F. de, 2006, Arq Bras Endocrinol Metab, V50, P390, DOI 10.1590/S0004-27302006000200025
   Després JP, 2008, LANCET, V371, P555, DOI 10.1016/S0140-6736(08)60261-5
   Despres JP, 2005, NEW ENGL J MED, V353, P2121, DOI 10.1056/NEJMoa044537
   Di Marzo V, 2001, NATURE, V410, P822, DOI 10.1038/35071088
   Di Marzo V, 1998, TRENDS NEUROSCI, V21, P521, DOI 10.1016/S0166-2236(98)01283-1
   Ducobu J, 2005, J Pharm Belg, V60, P84
   Ducobu J, 2005, Rev Med Brux, V26, P165
   *FDA, 2007, BREIF DOC
   Fride E, 2005, EXP BIOL MED, V230, P225
   Gary-Bobo M, 2007, HEPATOLOGY, V46, P122, DOI 10.1002/hep.21641
   Gelfand EV, 2006, J AM COLL CARDIOL, V47, P1919, DOI 10.1016/j.jacc.2005.12.067
   Gobbi G, 2005, P NATL ACAD SCI USA, V102, P18620, DOI 10.1073/pnas.0509591102
   GOLDSMITH SJ, 1992, INT J EAT DISORDER, V12, P63, DOI 10.1002/1098-108X(199207)12:1<63::AID-EAT2260120109>3.0.CO;2-5
   Gómez R, 2002, J NEUROSCI, V22, P9612
   Gosselin C, 2001, BMC Womens Health, V1, P2, DOI 10.1186/1472-6874-1-2
   Herling AW, 2008, ENDOCRINOLOGY, V149, P2557, DOI 10.1210/en.2007-1515
   Juan-Picó P, 2006, CELL CALCIUM, V39, P155, DOI 10.1016/j.ceca.2005.10.005
   Lean M, 2007, INT J CLIN PRACT, V61, P1555, DOI 10.1111/j.1742-1241.2007.01459.x
   LUTZ B, 2005, ENDOCANNABINOID SYST
   Mancini M C., 2002, Arq. Bras. Endocrinol. Metabol, V46, P497
   Mitchell PB, 2007, LANCET, V370, P1671, DOI 10.1016/S0140-6736(07)61705-X
   Pagotto U, 2006, INT J OBESITY, V30, pS39, DOI 10.1038/sj.ijo.0803277
   Pagotto U, 2006, ENDOCR REV, V27, P73, DOI 10.1210/er.2005-0009
   Pi-Sunyer F, 2006, JAMA-J AM MED ASSOC, V295, P761, DOI 10.1001/jama.295.7.761
   RINALDICARMONA M, 1994, FEBS LETT, V350, P240, DOI 10.1016/0014-5793(94)00773-X
   Scheen AJ, 2006, LANCET, V368, P1660, DOI 10.1016/S0140-6736(06)69571-8
   Steinberg BA, 2007, AM J CARDIOL, V100, p27P, DOI [10.1016/.j.amjcard.2007.10.011, 10.1016/j.amjcard.2007.10.011]
   TRILLOU CR, 2003, AM J PHYSIOL-REG I, V284, pR354
   Van Gaal LF, 2005, LANCET, V365, P1389, DOI 10.1016/S0140-6736(05)66374-X
   Van Gaal L, 2008, DIABETES CARE, V31, pS229, DOI 10.2337/dc08-s258
   Van Gaal LF, 2008, EUR HEART J, V29, P1761, DOI 10.1093/eurheartj/ehn076
   Vickers SP, 2005, CURR DRUG TARGETS, V6, P215, DOI 10.2174/1389450053174514
   WADDEN TA, 1993, ANN INTERN MED, V119, P688, DOI 10.7326/0003-4819-119-7_Part_2-199310011-00012
   Wadden TA, 2001, SURG CLIN N AM, V81, P1001, DOI 10.1016/S0039-6109(05)70181-X
   Wierzbicki AS, 2006, INT J CLIN PRACT, V60, P1697, DOI 10.1111/j.1742-1241.2006.01210.x
NR 41
TC 73
Z9 80
U1 0
U2 11
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1734-1140
EI 2299-5684
J9 PHARMACOL REP
JI Pharmacol. Rep.
PD MAR-APR
PY 2009
VL 61
IS 2
BP 217
EP 224
DI 10.1016/S1734-1140(09)70025-8
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 446PS
UT WOS:000266134200002
PM 19443932
DA 2025-06-11
ER

PT J
AU Walker, BR
   Soderberg, S
   Lindahl, B
   Olsson, T
AF Walker, BR
   Soderberg, S
   Lindahl, B
   Olsson, T
TI Independent effects of obesity and cortisol in predicting cardiovascular
   risk factors in men and women
SO JOURNAL OF INTERNAL MEDICINE
LA English
DT Article
DE blood pressure; glucocorticoids; insulin resistance; obesity
ID BODY-FAT DISTRIBUTION; INSULIN-RESISTANCE SYNDROME;
   POLYCYSTIC-OVARY-SYNDROME; PITUITARY-ADRENAL AXIS;
   11-BETA-HYDROXYSTEROID DEHYDROGENASE; ESSENTIAL-HYPERTENSION; ABDOMINAL
   OBESITY; SECRETION; STRESS
AB Objectives. Recent data suggest that higher plasma cortisol may be associated with hypertension and insulin resistance in otherwise healthy men, as it is in Cushing's syndrome. However, obesity in women is associated with lower plasma cortisol concentrations. This study sought to establish whether plasma cortisol is associated with cardiovascular risk factors in women as it is in men, and whether these relationships in either sex are confounded by obesity.
   Design. A population-based cross-sectional study.
   Setting. The MONICA study in northern Sweden.
   Subjects. From a target cohort of 2500, 1921 subjects took part and 226 were randomly selected because they attended between 07.00 and 09.00 h after an overnight fast. A 75 g oral glucose tolerance test was performed and blood sampled at baseline and 2 h after glucose.
   Results. Plasma cortisol was lower in relatively obese subjects: in men, this was observed only in the 2 h sample (r = -0.23, P = 0.02) and in women only in the fasting sample (r = -0.26, P < 0.01). Simple regression analysis did not identify relationships between plasma cortisol and blood pressure, serum lipids, fasting insulin or glucose tolerance. However, after adjusting for the effect of obesity by multiple regression, higher plasma cortisol was independently associated with higher diastolic blood pressure in men (r = 0.21, P = 0.04) but not in women, and higher fasting serum triglyceride levels in women (r = 0.28, P < 0.001) but not in men.
   Conclusions. Increasing obesity and plasma cortisol concentrations make independent and sex-specific contributions to variations in blood pressure and aspects of the insulin resistance syndrome. Adverse cardiovascular risk is greatest in those with the combination of obesity and failure to downregulate plasma cortisol levels.
C1 Univ Edinburgh, Western Gen Hosp, Dept Med, Edinburgh EH4 2XU, Midlothian, Scotland.
   Umea Univ, Dept Med, Univ Hosp, Umea, Sweden.
C3 University of Edinburgh; Umea University; Umea University Hospital
RP Walker, BR (corresponding author), Univ Edinburgh, Western Gen Hosp, Dept Med Sci, Edinburgh EH4 2XU, Midlothian, Scotland.
RI Söderberg, Stefan/AAG-3881-2019; Olsson, Tommy/KCZ-0891-2024
OI Soderberg, Stefan/0000-0001-9225-1306; Olsson, Tommy/0000-0001-7768-1076
CR Andrew R, 1998, J CLIN ENDOCR METAB, V83, P1806, DOI 10.1210/jc.83.5.1806
   Filipovsky J, 1996, J HYPERTENS, V14, P229, DOI 10.1097/00004872-199602000-00012
   HAUTANEN A, 1993, J INTERN MED, V234, P461, DOI 10.1111/j.1365-2796.1993.tb00779.x
   Korbonits M, 1996, CLIN ENDOCRINOL, V45, P699, DOI 10.1046/j.1365-2265.1996.8550865.x
   Ljung T, 1996, OBES RES, V4, P277, DOI 10.1002/j.1550-8528.1996.tb00546.x
   MARIN P, 1992, METABOLISM, V41, P882, DOI 10.1016/0026-0495(92)90171-6
   Pasquali R, 1996, METABOLISM, V45, P351, DOI 10.1016/S0026-0495(96)90290-5
   PASQUALI R, 1993, J CLIN ENDOCR METAB, V77, P341, DOI 10.1210/jc.77.2.341
   Phillips DIW, 1998, J CLIN ENDOCR METAB, V83, P757, DOI 10.1210/jc.83.3.757
   RODIN A, 1994, NEW ENGL J MED, V330, P460, DOI 10.1056/NEJM199402173300703
   Rosmond R, 1998, J CLIN ENDOCR METAB, V83, P1853, DOI 10.1210/jc.83.6.1853
   Söderberg S, 1999, J INTERN MED, V245, P533, DOI 10.1046/j.1365-2796.1999.00472.x
   SORO A, 1995, HYPERTENSION, V25, P67, DOI 10.1161/01.HYP.25.1.67
   STEWART PM, 1990, LANCET, V335, P431, DOI 10.1016/0140-6736(90)90664-Q
   Stolk RP, 1996, J ENDOCRINOL, V149, P313, DOI 10.1677/joe.0.1490313
   STRAIN GW, 1982, METABOLISM, V31, P209, DOI 10.1016/0026-0495(82)90054-3
   WALKER BR, 1993, CLIN ENDOCRINOL, V39, P221, DOI 10.1111/j.1365-2265.1993.tb01778.x
   Walker BR, 1996, HYPERTENSION, V27, P190, DOI 10.1161/01.HYP.27.2.190
   Walker BR, 1998, HYPERTENSION, V31, P891, DOI 10.1161/01.HYP.31.4.891
   WHITWORTH JA, 1989, CLIN ENDOCRINOL, V31, P355, DOI 10.1111/j.1365-2265.1989.tb01259.x
NR 20
TC 121
Z9 130
U1 0
U2 5
PU BLACKWELL SCIENCE LTD
PI OXFORD
PA P O BOX 88, OSNEY MEAD, OXFORD OX2 0NE, OXON, ENGLAND
SN 0954-6820
J9 J INTERN MED
JI J. Intern. Med.
PD FEB
PY 2000
VL 247
IS 2
BP 198
EP 204
DI 10.1046/j.1365-2796.2000.00609.x
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 289MQ
UT WOS:000085625900005
PM 10692082
DA 2025-06-11
ER

PT J
AU Lynch, EB
   Williams, J
   Avery, E
   Crane, MM
   Lange-Maia, B
   Tangney, C
   Jenkins, L
   Dugan, SA
   Emery-Tiburcio, EE
   Epting, SM
AF Lynch, Elizabeth B.
   Williams, Joselyn
   Avery, Elizabeth
   Crane, Melissa M.
   Lange-Maia, Brittney
   Tangney, Christy
   Jenkins, LaDawne
   Dugan, Sheila A.
   Emery-Tiburcio, Erin E.
   Epting, Steve M.
TI Partnering with Churches to Conduct a Wide-Scale Health Screening of an
   Urban, Segregated Community
SO JOURNAL OF COMMUNITY HEALTH
LA English
DT Article
DE African American; Health disparities; Surveillance; Segregation
ID BLOOD-PRESSURE-MEASUREMENT; RACIAL RESIDENTIAL SEGREGATION;
   UNITED-STATES; MEASUREMENT DEVICE; PHYSICAL-ACTIVITY; PRIMARY-CARE;
   DISPARITIES; CHICAGO; ASSOCIATION; MORTALITY
AB West Side Alive (WSA) is a partnership among pastors, church members and health researchers with the goal of improving health in the churches and surrounding community in the West Side of Chicago, a highly segregated African American area of Chicago with high rates of premature mortality and social disadvantage. To inform health intervention development, WSA conducted a series of health screenings that took place in seven partner churches. Key measures included social determinants of health and healthcare access, depression and PTSD screeners, and measurement of cardiometabolic risk factors, including blood pressure, weight, cholesterol and hemoglobin A1C (A1C). A total of 1106 adults were screened, consisting of WSA church members (n=687), members of the local community served by the church (n=339) and 80 individuals with unknown church status. Mean age was 52.8 years, 57% were female, and 67% reported at least one social risk factor (e.g. food insecurity). Almost all participants had at least one cardiovascular risk factor (92%), including 50% with obesity, 79% with elevated blood pressure and 65% with elevated A1C. A third of participants experienced >= 4 potentially traumatic events and 26% screened positive for depression and/or post-traumatic stress disorder. Participants were given personalized health reports and referred to services as needed. Information from the screenings will be used to inform the design of interventions targeting the West Side community and delivered in partnership with the churches. Sharing these results helped mobilize community members to improve their own health and the health of their community.
C1 [Lynch, Elizabeth B.] Rush Univ, Med Ctr, Dept Prevent Med, 1700 West Van Buren,Suite 470, Chicago, IL 60612 USA.
   [Williams, Joselyn; Avery, Elizabeth; Crane, Melissa M.; Lange-Maia, Brittney] Rush Univ, Med Ctr, Dept Prevent Med, Chicago, IL 60612 USA.
   [Tangney, Christy] Rush Univ, Med Ctr, Coll Hlth Sci, Dept Clin Nutr,Res, Chicago, IL 60612 USA.
   [Jenkins, LaDawne] Rush Univ, Med Ctr, Dept Community Engagement, Chicago, IL 60612 USA.
   [Dugan, Sheila A.] Rush Univ, Med Ctr, Dept Phys Med & Rehabil, Chicago, IL 60612 USA.
   [Emery-Tiburcio, Erin E.] Rush Univ, Med Ctr, Dept Psychiat & Behav Sci, Chicago, IL 60612 USA.
   [Epting, Steve M.] Hope Community Church, Chicago, IL 60651 USA.
C3 Rush University; Rush University; Rush University; Rush University; Rush
   University; Rush University
RP Lynch, EB (corresponding author), Rush Univ, Med Ctr, Dept Prevent Med, 1700 West Van Buren,Suite 470, Chicago, IL 60612 USA.
EM Elizabeth_lynch@rush.edu
OI Crane, Melissa/0000-0002-1458-2692; Emery-Tiburcio,
   Erin/0000-0002-6878-3369; Lynch, Elizabeth/0000-0003-0575-711X
FU National Heart, Lung and Blood Institute of the National Institutes of
   Health [R56HL135247]; Rush University Medical Center Department of
   Community Engagement; Foglia Family Foundation
FX We acknowledge the pastors, church coordinators and churches that
   participated in this study: Kandice Jones and Hope Community Church,
   Pastor Steve Spiller, Catherine Banks and Greater Galilee Missionary
   Baptist (MB) Church, Pastor Marshall Hatch, Rochelle Sykes, Gigi Fuller
   and New Mount Pilgrim MB Church, Pastor Cy Fields, Jessica Hudnall, and
   New Landmark MB Church, Pastor Ira Acree, Patty Ringo and Greater St.
   John Bible Church, Pastor Floyd James, Sr., Precious James and Greater
   Rock MB Church, and Pastor Michael Bryant, Tamara Gear and Kedvale New
   Mt. Zion MB Church. Numerous volunteers from each church also helped
   conduct the health screenings. In addition, numerous volunteers and
   staff from Rush University Medical Center helped with the screenings,
   including Wil Mims, Serena Sylvestri, and Shelby Gilyard. Research
   reported in this publication was supported by National Heart, Lung and
   Blood Institute of the National Institutes of Health under Award Number
   R56HL135247. The content is solely the responsibility of the authors and
   does not necessarily represent the official views of the National
   Institutes of Health. We would also like to thank Dr. David Ansell and
   Darlene Hightower and the Rush University Medical Center Department of
   Community Engagement for providing additional funding for this study.
   Funding was also provided by the Foglia Family Foundation.
CR Adler NE, 2000, HEALTH PSYCHOL, V19, P586, DOI 10.1037/0278-6133.19.6.586
   Al Kibria GM, 2019, PREV MED REP, V14, DOI 10.1016/j.pmedr.2019.100850
   Anderson E. E., 2011, CIRTIFICATION COMMUN
   [Anonymous], CHICAGO DEFENDER
   [Anonymous], PREV DIAGN DIAB
   [Anonymous], PROGR COMMUNITY HLTH
   Blackwell Debra L, 2014, Vital Health Stat 10, P1
   Blumberg SJ, 1999, AM J PUBLIC HEALTH, V89, P1231, DOI 10.2105/AJPH.89.8.1231
   Breslau J, 2018, HEALTH SERV RES, V53, P1286, DOI 10.1111/1475-6773.12728
   Centers for Disease Control and Prevention, AFR AM TOB US
   Chaves M, 2001, NONPROF VOLUNT SEC Q, V30, P660, DOI 10.1177/0899764001304003
   Cohen JB, 2017, J CLIN HYPERTENS, V19, P296, DOI 10.1111/jch.12961
   Cunningham SA, 2018, ANN EPIDEMIOL, V28, P20, DOI 10.1016/j.annepidem.2017.11.002
   Dircksen Jaime C., 2016, Healthy Chicago 2.0: Partnering to Improve Health Equity
   Geronimus AT, 2011, AM J PUBLIC HEALTH, V101, P720, DOI 10.2105/AJPH.2010.195537
   Geronimus AT, 2006, AM J PUBLIC HEALTH, V96, P826, DOI 10.2105/AJPH.2004.060749
   Gillum RF, 2006, ANN BEHAV MED, V31, P30, DOI 10.1207/s15324796abm3101_6
   Godbolt D, 2018, J RELIG HEALTH, V57, P2140, DOI 10.1007/s10943-017-0490-1
   Gray MJ, 2004, ASSESSMENT, V11, P330, DOI 10.1177/1073191104269954
   GURALNIK JM, 1994, J GERONTOL, V49, pM85, DOI 10.1093/geronj/49.2.M85
   Hunt B, 2015, J RACIAL ETHN HEALTH, V2, P93, DOI 10.1007/s40615-014-0052-0
   Hunt BR, 2015, J RACIAL ETHN HEALTH, V2, P425, DOI 10.1007/s40615-015-0089-8
   Kershaw KN, 2016, CURR DIABETES REP, V16, DOI 10.1007/s11892-016-0800-0
   Kroenke K, 2009, J AFFECT DISORDERS, V114, P163, DOI 10.1016/j.jad.2008.06.026
   Mechanic D, 2002, HEALTH AFFAIR, V21, P48, DOI 10.1377/hlthaff.21.2.48
   Mehra R, 2017, SOC SCI MED, V191, P237, DOI 10.1016/j.socscimed.2017.09.018
   Murray CJL, 2006, PLOS MED, V3, P1513, DOI 10.1371/journal.pmed.0030260
   Orsi JM, 2010, AM J PUBLIC HEALTH, V100, P349, DOI 10.2105/AJPH.2009.165407
   Ostchega Y., 2012, Blood Pressure Randomized Methodology Study Comparing Automatic Oscillometric and Mercury Sphygmomanometer Devices: National Health and Nutrition Examination Survey, 2009-2010
   Ostchega Y, 2016, BLOOD PRESS MONIT, V21, P345, DOI 10.1097/MBP.0000000000000208
   Ostchega Y, 2010, J CLIN HYPERTENS, V12, P22, DOI 10.1111/j.1751-7176.2009.00199.x
   Paknikar Sujaytha, 2016, J Diabetes Sci Technol, V10, P1308
   Pickering TG, 2005, CIRCULATION, V111, P697, DOI 10.1161/01.CIR.0000154900.76284.F6
   Pluddemann Annette, 2012, Br J Gen Pract, V62, pe224, DOI 10.3399/bjgp12X630241
   Prins A, 2016, J GEN INTERN MED, V31, P1206, DOI 10.1007/s11606-016-3703-5
   Saelens BE, 2003, AM J PUBLIC HEALTH, V93, P1552, DOI 10.2105/AJPH.93.9.1552
   Sampson R.J., 1995, Crime and inequality, P37, DOI 10.1515/9781503615557-004
   Shah SN, 2014, PREV CHRONIC DIS, V11, DOI 10.5888/pcd11.130440
   Siegel R, 2012, CA-CANCER J CLIN, V62, P10, DOI 10.3322/caac.20138
   Simons RL, 2018, DEV PSYCHOL, V54, P1993, DOI 10.1037/dev0000511
   Spottswood M, 2017, HARVARD REV PSYCHIAT, V25, P159, DOI 10.1097/HRP.0000000000000136
   Wallerstein NB, 2006, HEALTH PROMOT PRACT, V7, P312, DOI 10.1177/1524839906289376
   Williams DR, 2016, J HEALTH POLIT POLIC, V41, P627, DOI 10.1215/03616878-3620857
   Williams DR, 2016, HEALTH PSYCHOL, V35, P407, DOI 10.1037/hea0000242
   Williams DR, 2001, PUBLIC HEALTH REP, V116, P404, DOI 10.1016/S0033-3549(04)50068-7
NR 45
TC 13
Z9 19
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0094-5145
EI 1573-3610
J9 J COMMUN HEALTH
JI J. Community Health
PD FEB
PY 2020
VL 45
IS 1
BP 98
EP 110
DI 10.1007/s10900-019-00715-9
PG 13
WC Health Policy & Services; Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA KQ7PR
UT WOS:000517113200012
PM 31399892
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chen, LC
   Chen, JW
   Wu, MH
   Liu, JC
   Lan, GY
   Ding, PYA
   Chang, MS
AF Chen, LC
   Chen, JW
   Wu, MH
   Liu, JC
   Lan, GY
   Ding, PYA
   Chang, MS
TI Differential coronary calcification on electron-beam CT between syndrome
   X and coronary artery disease in patients with chronic stable angina
   pectoris
SO CHEST
LA English
DT Article
DE coronary artery disease; coronary calcification; electron-beam CT;
   syndrome X
ID ULTRAFAST COMPUTED-TOMOGRAPHY; AMERICAN-HEART-ASSOCIATION; TERM
   FOLLOW-UP; CHEST PAIN; CALCIUM; EXERCISE; ARTERIOGRAMS; STRESS;
   QUANTIFICATION; ANGIOGRAMS
AB Study objectives: The differential diagnosis of syndrome X and coronary artery disease (CAD) in patients with evidence of myocardial ischemia may be difficult. The possible difference in coronary calcium detected by electron-beam CT (EBCT) between syndrome X and CAD is rarely evaluated, especially in aged patients with chronic, stable angina.
   Design and settings: Prospective, controlled study at a tertiary referral medical center.
   Patients and measurements: Forty patients with syndrome X (85% male) and 53 patients with CAD (89% male) were enrolled. Ten control subjects (90% male) with negative exercise treadmill test results and normal coronary angiographic findings served as control subjects. EBCT determined the coronary calcium scores (CCSs), and standard cardiovascular risk factors of all study subjects were analyzed.
   Results: The 93 study patients had CCSs that ranged from 0 to 1,857. Coronary calcification was seen in 2 of the 10 control subjects (20%),21 of the 40 syndrome X patients (52.5%), and 51 of the 53 CAD patients (96.2%) [p<0.01.]. The CCS (median [range]) was significantly lower in syndrome X patients than in CAD patients: 1 (0 to 117) vs 202 (0 to 1,857) [p<0.001]. Receiver operating characteristic curve analyses also demonstrated that coronary calcification differentiated syndrome X from CAD (area under curve, 0.891; 95% confidence interval, 0.806 to 0.947). Of the CAD patients whose CCSs were <117 and overlapped with CCSs of syndrome X multivariate analyses determined CCS >5 (odds ratio, 13.1; 95% confidence interval, 2.86 to 59.7), hypertension (odds ratio, 6.4; 95% confidence interval, 1.5 to 27.4), and hypercholesterolemia (odds ratio, 6.7; 95% confidence interval, 1.5 to 30.5) to be independent discriminators to differentiate CAD from syndrome X. Patients with CAD had more frequent hypertension than patients with syndrome X.
   Conclusions: The coronary calcium detected noninvasively by EBCT was different, though with some overlapping, between patients Kith syndrome X and CAD. In addition to standard cardiovascular risk factors, CCS determined by EBCT (especially >117 or = 0) could differentiate between syndrome X and CAD in patients with chronic, stable angina with evidence of myocardial ischemia. Larger trials would be useful to validate CCS on EBCT as a predictor of clinical outcome in these patients.
C1 Vet Gen Hosp, Dept Med, Div Cardiol, Taipei 11217, Taiwan.
   Natl Yang Ming Univ, Sch Med, Cardiovasc Res Ctr, Taipei 112, Taiwan.
   Vet Gen Hosp, Dept Radiol, Taipei, Taiwan.
   Taipei Med Univ, Div Cardiovasc Med, Taipei, Taiwan.
   Taipei Wan Fang Hosp, Taipei, Taiwan.
   Cheng Hsin Gen Hosp, Dept Med Imaging, Taipei, Taiwan.
C3 National Yang Ming Chiao Tung University; Taipei Medical University;
   Taipei Municipal WanFang Hospital; Cheng Hsin General Hospital
RP Chen, JW (corresponding author), Vet Gen Hosp, Dept Med, Div Cardiol, 201 Shih Pai Rd,Sect 2, Taipei 11217, Taiwan.
CR AGATSTON AS, 1990, J AM COLL CARDIOL, V15, P827, DOI 10.1016/0735-1097(90)90282-T
   Arad Y, 1996, CIRCULATION, V93, P1951, DOI 10.1161/01.CIR.93.11.1951
   BLANKENHORN D, 1961, AM J MED SCI, V242, P1, DOI 10.1097/00000441-196107000-00001
   CAMICI PG, 1991, J AM COLL CARDIOL, V17, P1461, DOI 10.1016/0735-1097(91)90632-J
   CANNON RO, 1992, CIRCULATION, V85, P883, DOI 10.1161/01.CIR.85.3.883
   CANNON RO, 1988, AM J CARDIOL, V61, P1338, DOI 10.1016/0002-9149(88)91180-0
   Chen JW, 1996, JPN HEART J, V37, P865
   Detrano R, 1996, J AM COLL CARDIOL, V27, P285, DOI 10.1016/0735-1097(95)00460-2
   Detrano RC, 1999, CIRCULATION, V99, P2633, DOI 10.1161/01.CIR.99.20.2633
   DETRANO RC, 1994, J AM COLL CARDIOL, V24, P354, DOI 10.1016/0735-1097(94)90287-9
   DEVRIES S, 1995, AM J CARDIOL, V75, P973, DOI 10.1016/S0002-9149(99)80706-1
   Gibbons RJ, 1999, J AM COLL CARDIOL, V33, P2092, DOI 10.1016/S0735-1097(99)00150-3
   Guerci AD, 1998, J AM COLL CARDIOL, V32, P673, DOI 10.1016/S0735-1097(98)00299-X
   JANOWITZ WR, 1993, AM J CARDIOL, V72, P247, DOI 10.1016/0002-9149(93)90668-3
   JANOWITZ WR, 1991, AM J CARDIOL, V68, P1, DOI 10.1016/0002-9149(91)90700-U
   KAJINAMI K, 1995, J AM COLL CARDIOL, V26, P1209, DOI 10.1016/0735-1097(95)00314-2
   KASKI JC, 1995, J AM COLL CARDIOL, V25, P807, DOI 10.1016/0735-1097(94)00507-M
   KASKI JC, 1991, J AM COLL CARDIOL, V18, P50, DOI 10.1016/S0735-1097(10)80216-5
   KEMP HG, 1973, AM J MED, V54, P735, DOI 10.1016/0002-9343(73)90060-0
   MARTIN CM, 1972, CIRCULATION, V46, P956, DOI 10.1161/01.CIR.46.5.956
   McLaughlin VV, 1999, AM J CARDIOL, V84, P327, DOI 10.1016/S0002-9149(99)00286-6
   OPHERK D, 1989, CIRCULATION, V80, P1610, DOI 10.1161/01.CIR.80.6.1610
   PERIN E, 1991, CATHETER CARDIO DIAG, V22, P45, DOI 10.1002/ccd.1810220111
   PUPITA G, 1990, AM HEART J, V120, P848, DOI 10.1016/0002-8703(90)90200-H
   RADICE M, 1995, AM J CARDIOL, V75, P620, DOI 10.1016/S0002-9149(99)80630-4
   RADICE M, 1994, AM J CARDIOL, V73, P968, DOI 10.1016/0002-9149(94)90143-0
   RUMBERGER JA, 1995, CIRCULATION, V92, P2157, DOI 10.1161/01.CIR.92.8.2157
   RUMBERGER JA, 2000, ACC CURR REV, V9, P78
   Shemesh J, 1997, RADIOLOGY, V205, P697, DOI 10.1148/radiology.205.3.9393523
   Shemesh J, 1998, AM J CARDIOL, V81, P271, DOI 10.1016/S0002-9149(97)00899-0
   SIMONS DB, 1992, J AM COLL CARDIOL, V20, P1118, DOI 10.1016/0735-1097(92)90367-V
   STUART RJ, 1976, AM J CARDIOL, V37, P19, DOI 10.1016/0002-9149(76)90493-8
   WARBURTO.RK, 1968, RADIOLOGY, V91, P109
   Wexler L, 1996, CIRCULATION, V94, P1175, DOI 10.1161/01.CIR.94.5.1175
   WIEDERMANN JG, 1995, J AM COLL CARDIOL, V25, P1310, DOI 10.1016/0735-1097(94)00556-6
   Wu TC, 2000, AM J CARDIOL, V85, P1071, DOI 10.1016/S0002-9149(00)00698-6
NR 36
TC 8
Z9 8
U1 0
U2 1
PU AMER COLL CHEST PHYSICIANS
PI NORTHBROOK
PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA
SN 0012-3692
J9 CHEST
JI Chest
PD NOV
PY 2001
VL 120
IS 5
BP 1525
EP 1533
DI 10.1378/chest.120.5.1525
PG 9
WC Critical Care Medicine; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Respiratory System
GA 494GW
UT WOS:000172274300022
PM 11713130
DA 2025-06-11
ER

PT J
AU Garduño-Diaz, SD
   Khokhar, S
AF Garduno-Diaz, S. D.
   Khokhar, S.
TI South Asian dietary patterns and their association with risk factors for
   the metabolic syndrome
SO JOURNAL OF HUMAN NUTRITION AND DIETETICS
LA English
DT Article
DE dietary acculturation; ethnicity; noncommunicable diseases; obesity;
   transition diet
ID PRINCIPAL-COMPONENTS-ANALYSIS; CORONARY-HEART-DISEASE; NONCOMMUNICABLE
   DISEASES; NUTRITION TRANSITION; CARDIOVASCULAR RISK; PHYSICAL-ACTIVITY;
   MENTAL-HEALTH; WOMEN; POPULATION; PREVALENCE
AB Background Certain dietary patterns have been associated with higher risk of noncommunicable diseases, with South Asians identified as a high-risk group. The present study aimed to identify the association between dietary patterns and the metabolic syndrome (MS) in South Asians living in the UK. Methods Dietary patterns were derived by principal component analysis from 15 different food groups using an ethnic-specific food frequency questionnaire. MS risk factors, including obesity and hypertension, were measured, whereas existing conditions of dyslipidaemia and hyperglycaemia were self-reported. Participants (n=100) were divided into quartiles based on dietary factor scores and the link between dietary patterns and risk factors was investigated. Results Three different patterns were derived, which together explained 46% of the total diet variation; eastern pattern, mixed pattern and western pattern. An inverse correlation was found between the eastern pattern and education P=0.05). A direct correlation was found between the western pattern and physical activity (P=0.05) and the overall risk of MS (P=0.05). Body composition was altered as residence time in the UK increased, with a reduction in muscle mass (2926%) and an increase in body fat (3137%). Diagnosis criteria for MS were found in 20% of the participants. Conclusions Dietary acculturation, including a reduction in vegetarianism, an increased intake of caffeinated drinks and altered meal patterns, may be associated with the higher prevalence of MS in migrant South Asians in the UK.
C1 [Garduno-Diaz, S. D.; Khokhar, S.] Univ Leeds, Sch Food Sci & Nutr, Leeds LS2 9JT, W Yorkshire, England.
C3 University of Leeds
RP Garduño-Diaz, SD (corresponding author), Univ Leeds, Sch Food Sci & Nutr, Leeds LS2 9JT, W Yorkshire, England.
EM fssdgd@leeds.ac.uk
FU Mexican National Council of Science and Technology (CONACYT)
FX SDGD thanks the Mexican National Council of Science and Technology
   (CONACYT) for PhD sponsorship. The authors would also like to
   acknowledge the European Food Information Resource Network (EuroFIR) and
   the Food Standards Agency for food composition data.
CR Aarabi M, 2004, EUR J CARDIOV PREV R, V11, P389, DOI 10.1097/00149831-200410000-00005
   Ahmad F, 2004, WOMEN HEALTH, V40, P113, DOI 10.1300/J013v40n04_07
   Ajjan R, 2007, J THROMB HAEMOST, V5, P754, DOI 10.1111/j.1538-7836.2007.02434.x
   [Anonymous], 2000, ASIA PACIFIC PERSPEC
   Azizi F, 2009, TRIALS, V10, DOI 10.1186/1745-6215-10-5
   Balasubramanyam A, 2008, J IMMIGR MINOR HEALT, V10, P313, DOI 10.1007/s10903-007-9092-4
   Cho ER, 2011, PUBLIC HEALTH NUTR, V14, P356, DOI 10.1017/S1368980010002685
   Cunha DB, 2010, BRIT J NUTR, V104, P908, DOI 10.1017/S0007114510001479
   Dawson AJ, 2005, ETHNIC HEALTH, V10, P293, DOI 10.1080/13557850500159965
   De Irala-Estévez J, 2000, EUR J CLIN NUTR, V54, P706, DOI 10.1038/sj.ejcn.1601080
   Esmaillzadeh A, 2007, AM J CLIN NUTR, V85, P910, DOI 10.1093/ajcn/85.3.910
   Forouhi NG, 2006, DIABETOLOGIA, V49, P2580, DOI 10.1007/s00125-006-0393-2
   Gilbert PA, 2008, NUTR REV, V66, P203, DOI 10.1111/j.1753-4887.2008.00025.x
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Health and Social Care Information Centre, 2010, STAT OB PHYS ACT DIE
   Heidemann C, 2008, CIRCULATION, V118, P230, DOI 10.1161/CIRCULATIONAHA.108.771881
   Hjellset VT, 2011, J IMMIGR MINOR HEALT, V13, P732, DOI 10.1007/s10903-010-9409-6
   International Diabetes Federation, 2006, RAT NEW IDF WORLDW D
   Jacka FN, 2010, AM J PSYCHIAT, V167, P305, DOI 10.1176/appi.ajp.2009.09060881
   Keijzers GB, 2002, DIABETES CARE, V25, P364, DOI 10.2337/diacare.25.2.364
   Khokhar S, 2010, EUR J CLIN NUTR, V64, pS82, DOI 10.1038/ejcn.2010.216
   Koochek A, 2008, EUR J CLIN NUTR, V62, P1326, DOI 10.1038/sj.ejcn.1602851
   Lamberts SWJ, 1997, SCIENCE, V278, P419, DOI 10.1126/science.278.5337.419
   MCKEIGUE PM, 1991, LANCET, V337, P382, DOI 10.1016/0140-6736(91)91164-P
   Merchant AT, 2007, AM J CLIN NUTR, V85, P225
   Middelkoop BJC, 1999, INT J EPIDEMIOL, V28, P1119, DOI 10.1093/ije/28.6.1119
   Misra A, 2011, INT J OBESITY, V35, P167, DOI 10.1038/ijo.2010.135
   Misra A, 2009, BRIT J NUTR, V101, P465, DOI 10.1017/S0007114508073649
   National Institute of Health and Clinical Excellence, 2006, PHYS ACT GUID
   Nettleton JA, 2007, AM J CLIN NUTR, V85, P1615, DOI 10.1093/ajcn/85.6.1615
   Newcomer JW, 2007, AM J MANAG CARE, V13, pS170
   Noel SE, 2009, J NUTR, V139, P1360, DOI 10.3945/jn.109.105874
   Norton K., 2004, ANTHROPOMETRICA
   O'Brien E, 2003, J HYPERTENS, V21, P821, DOI 10.1097/00004872-200305000-00001
   Osborn DPJ, 2008, BMC PSYCHIATRY, V8, DOI 10.1186/1471-244X-8-84
   Pallant J., 2011, SURVIVAL MANUAL STEP
   Panagiotakos DB, 2007, J AM DIET ASSOC, V107, P979, DOI 10.1016/j.jada.2007.03.006
   Paradis AM, 2006, INT J BEHAV NUTR PHY, V3, DOI 10.1186/1479-5868-3-38
   Pernice R, 2009, INT J SOC PSYCHIATR, V55, P272, DOI 10.1177/0020764008093685
   Pollard TM, 2008, AM J HUM BIOL, V20, P545, DOI 10.1002/ajhb.20773
   Popkin BM, 2001, NUTR REV, V59, P379, DOI 10.1111/j.1753-4887.2001.tb06967.x
   Pryer JA, 2001, PUBLIC HEALTH NUTR, V4, P787, DOI 10.1079/PHN200098
   Rizzo NS, 2011, DIABETES CARE, V34, P1225, DOI 10.2337/dc10-1221
   Schulze MB, 2006, OBESITY, V14, P1444, DOI 10.1038/oby.2006.164
   Sevak L, 2004, EUR J NUTR, V43, P160, DOI 10.1007/s00394-004-0454-6
   Sharma S, 1999, PUBLIC HEALTH NUTR, V2, P469, DOI 10.1017/S1368980099000658
   Simmons D, 1997, BRIT J NUTR, V78, P5, DOI 10.1079/BJN19970114
   Sriskantharajah J, 2007, FAM PRACT, V24, P71, DOI 10.1093/fampra/cml066
   Statistics UK, 2008, 2001 CENS
   Tillin T, 2005, DIABETOLOGIA, V48, P649, DOI 10.1007/s00125-005-1689-3
   Wandel M, 2008, APPETITE, V50, P376, DOI 10.1016/j.appet.2007.09.003
   Williams R, 1997, PSYCHOL MED, V27, P1173, DOI 10.1017/S0033291797005473
   Zhang Y, 2011, NUTR METAB CARDIOVAS, V21, P418, DOI 10.1016/j.numecd.2009.10.020
NR 53
TC 45
Z9 52
U1 0
U2 43
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0952-3871
EI 1365-277X
J9 J HUM NUTR DIET
JI J. Hum. Nutr. Diet.
PD APR
PY 2013
VL 26
IS 2
BP 145
EP 155
DI 10.1111/j.1365-277X.2012.01284.x
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 107NN
UT WOS:000316224600004
PM 22943473
DA 2025-06-11
ER

PT J
AU Shah, D
   Singh, B
   Varnika, FNU
   Fredrick, FC
   Meda, AKR
   Aggarwal, K
   Jain, R
AF Shah, Darshini
   Singh, Bhupinder
   Varnika, F. N. U.
   Fredrick, Fremita Chelsea
   Meda, Anish Kumar Reddy
   Aggarwal, Kanishk
   Jain, Rohit
TI Linking hearts and minds: understanding the cardiovascular impact of
   bipolar disorder
SO FUTURE CARDIOLOGY
LA English
DT Review
DE bipolar disorder; cardiovascular disorder; heart brain axis; smoking;
   typical antipsychotics
ID MAJOR DEPRESSIVE DISORDER; SEVERE MENTAL-ILLNESS; METABOLIC SYNDROME;
   MYOCARDIAL-INFARCTION; RISK-FACTORS; DISEASE; PREVALENCE; MORTALITY;
   METAANALYSIS; ASSOCIATION
AB Bipolar disorder is a severe and recurring condition that has become a significant public health issue globally. Studies indicate a heightened risk and earlier onset of cardiovascular diseases among individuals with bipolar disorder, potentially increasing mortality rates. The chronic nature of bipolar disorder leads to disturbances across multiple systems, including autonomic dysfunction, over-activation of the hypothalamic-pituitary-adrenal axis and increased levels of peripheral inflammatory markers. These disruptions cause endothelial damage, the formation of plaques and blood clots, in addition to the medications used to treat bipolar disorder and genetic associations contributing to cardiovascular disease development. Understanding the complex interplay between bipolar disorder and cardiovascular events is essential for the prevention and effective management of cardiovascular conditions in individuals with bipolar disorder.
   PLAIN LANGUAGE SUMMARY
   Bipolar disorder is a mental health condition that affects mood and behavior, significantly impacting the lives of many people around the world. People with this disorder are also at a higher risk for heart diseases, including heart attacks and strokes. Certain lifestyle factors, common among people with bipolar disorder, such as smoking, poor diet and lack of exercise, can cause inflammation and stress, which damage blood vessels and increase the likelihood of heart conditions. The relationship between bipolar disorder and heart disease is complex. The condition affects how the body handles stress and can disrupt normal heart functions. For instance, stress from bipolar disorder can lead to high blood pressure and irregular heartbeats and certain medications taken by those with bipolar disorder can further damage the heart. To better manage these risks, it's important to understand the connection between bipolar disorder and heart disease. Future research should focus on creating guidelines for regular heart health check-ups for people with bipolar disorder and improving overall care to help prevent unfavorable outcomes.
C1 [Shah, Darshini] GCS Med Coll Hosp & Res Ctr, Dept Psychiat, Ahmadabad 380025, Gujarat, India.
   [Singh, Bhupinder] NYC Hlth Hosp Queens, Icahn Sch Med Mt Sinai, Dept Med, New York, NY 11432 USA.
   [Varnika, F. N. U.] Maharishi Markandeshwar Inst Med Sci & Res, Dept Med, Mullana 133207, India.
   [Fredrick, Fremita Chelsea; Meda, Anish Kumar Reddy] Avalon Univ, Dept Med, Sch Med, Willemstad, Curacao.
   [Aggarwal, Kanishk] Dayanand Med Coll & Hosp, Ludhiana 141001, India.
   [Jain, Rohit] Penn State Hlth Milton S Hershey Med Ctr, Hershey, PA 17033 USA.
C3 Icahn School of Medicine at Mount Sinai; Maharishi Markandeshwar
   University; Dayanand Medical College & Hospital; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Pennsylvania State
   University; Penn State Health
RP Varnika, FNU (corresponding author), Maharishi Markandeshwar Inst Med Sci & Res, Dept Med, Mullana 133207, India.
EM varnikafnu@gmail.com
RI Aggarwal, Kanishk/MBV-6086-2025; Shah, Darshini/KHZ-4975-2024; Singh,
   Bhupinder/JFS-4057-2023
OI Shah, Darshini/0009-0003-2175-2877; Singh,
   Bhupinder/0009-0004-9218-0885; Meda, Anish Kumar
   Reddy/0009-0008-2008-5992; Fredrick, Fremita/0009-0002-3341-7251;
   Aggarwal, Kanishk/0009-0005-7518-446X
CR Abosi O, 2018, HORM MOL BIOL CLIN I, V36, DOI 10.1515/hmbci-2017-0065
   Aggarwal K, 2025, CARDIOL REV, V33, P219, DOI 10.1097/CRD.0000000000000600
   Almulla AF, 2023, BRAIN BEHAV IMMUN, V113, P374, DOI 10.1016/j.bbi.2023.08.007
   Bauer IE, 2014, J PSYCHIATR RES, V56, P18, DOI 10.1016/j.jpsychires.2014.04.017
   Beltrán-Sánchez H, 2013, J AM COLL CARDIOL, V62, P697, DOI 10.1016/j.jacc.2013.05.064
   Bonifácio KL, 2021, J AFFECT DISORDERS, V278, P226, DOI 10.1016/j.jad.2020.09.040
   Castaldelli-Maia JM, 2022, INT REV PSYCHIATR, V34, P6, DOI 10.1080/09540261.2022.2040450
   Checa J, 2020, J INFLAMM RES, V13, P1057, DOI 10.2147/JIR.S275595
   Chen PH, 2020, J AFFECT DISORDERS, V274, P210, DOI 10.1016/j.jad.2020.05.094
   Chung FP, 2014, ACTA CARDIOL SIN, V30, P53
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   Crump C, 2013, JAMA PSYCHIAT, V70, P931, DOI 10.1001/jamapsychiatry.2013.1394
   Crusey A, 2020, J HEALTHC QUAL RES, V35, P167, DOI 10.1016/j.jhqr.2020.03.001
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P138
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   Fatkhullina AR, 2016, BIOCHEMISTRY-MOSCOW+, V81, P1358, DOI 10.1134/S0006297916110134
   Ferrari AJ, 2016, BIPOLAR DISORD, V18, P440, DOI 10.1111/bdi.12423
   Fiedorowicz JG, 2008, ANN CLIN PSYCHIATRY, V20, P131, DOI 10.1080/10401230802177722
   Foroughi M, 2022, PSYCHOSOM MED, V84, P97, DOI 10.1097/PSY.0000000000001017
   Francula-Zaninovic S, 2018, CURR CARDIOL REV, V14, P153, DOI 10.2174/1573403X14666180222102312
   Fries GR, 2019, PHARMACOL BIOCHEM BE, V177, P12, DOI 10.1016/j.pbb.2018.12.006
   Ganguly P, 2015, NUTR J, V14, DOI 10.1186/1475-2891-14-6
   Goh GH, 2019, BIOLOGY-BASEL, V8, DOI 10.3390/biology8010015
   Goldfarb M, 2022, J AM COLL CARDIOL, V80, P918, DOI 10.1016/j.jacc.2022.06.017
   Goldstein BI, 2017, CAN J CARDIOL, V33, P1565, DOI 10.1016/j.cjca.2017.10.006
   Goldstein BI, 2015, CIRCULATION, V132, P965, DOI 10.1161/CIR.0000000000000229
   Goldstein BI, 2015, J CLIN PSYCHIAT, V76, P163, DOI 10.4088/JCP.14m09300
   Goldstein BI, 2009, BIPOLAR DISORD, V11, P657, DOI 10.1111/j.1399-5618.2009.00735.x
   Grundtvig M, 2009, EUR J CARDIOV PREV R, V16, P174, DOI 10.1097/HJR.0b013e328325d7f0
   Hales CM, 2018, JAMA-J AM MED ASSOC, V319, P1723, DOI 10.1001/jama.2018.3060
   Hansen PS, 2019, BIPOLAR DISORD, V21, P270, DOI 10.1111/bdi.12684
   Heffner JL, 2011, BIPOLAR DISORD, V13, P439, DOI 10.1111/j.1399-5618.2011.00943.x
   Henein MY, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms232112906
   Henry BL, 2010, J PSYCHIATR RES, V44, P168, DOI 10.1016/j.jpsychires.2009.07.011
   Hsu JH, 2021, J AFFECT DISORDERS, V281, P721, DOI 10.1016/j.jad.2020.11.083
   Hu JR, 2023, CURR CARDIOL REP, V25, P1745, DOI 10.1007/s11886-023-01990-8
   Juan CA, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22094642
   Kato ET, 2023, EUR HEART J, V44, P293, DOI 10.1093/eurheartj/ehac577
   Kessler RC, 2006, AM J PSYCHIAT, V163, P1561, DOI 10.1176/appi.ajp.163.9.1561
   Kilbourne AM, 2007, J AFFECT DISORDERS, V102, P145, DOI 10.1016/j.jad.2007.01.006
   Knedeisen F, 2023, J AFFECT DISORDERS, V324, P410, DOI 10.1016/j.jad.2022.12.072
   La Rovere MT, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.00582
   Lambert AM, 2022, PLOS MED, V19, DOI 10.1371/journal.pmed.1003960
   Leboyer M, 2012, J AFFECT DISORDERS, V141, P1, DOI 10.1016/j.jad.2011.12.049
   Lee YB, 2024, SCI REP-UK, V14, DOI 10.1038/s41598-024-51757-6
   Levenberg K, 2023, MED HYPOTHESES, V170, DOI 10.1016/j.mehy.2022.110986
   Levenberg K, 2021, MED HYPOTHESES, V146, DOI 10.1016/j.mehy.2020.110433
   Li XH, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-07928-9
   Liu GD, 2022, BIPOLAR DISORD, V24, P48, DOI 10.1111/bdi.13082
   Manchia M, 2024, AM J PSYCHIAT, V181, P4, DOI 10.1176/appi.ajp.20230921
   McIntyre RS, 2010, J AFFECT DISORDERS, V126, P366, DOI 10.1016/j.jad.2010.04.012
   Mehta N, 2017, CLIN CARDIOL, V40, P1363, DOI 10.1002/clc.22822
   Meng L, 2012, J HYPERTENS, V30, P842, DOI 10.1097/HJH.0b013e32835080b7
   Merikangas KR, 2011, ARCH GEN PSYCHIAT, V68, P241, DOI 10.1001/archgenpsychiatry.2011.12
   Mitchell AJ, 2015, GEN HOSP PSYCHIAT, V37, P14, DOI 10.1016/j.genhosppsych.2014.11.006
   Munkholm K, 2012, BIPOLAR DISORD, V14, P684, DOI 10.1111/bdi.12005
   Mutz J, 2022, BMC MED, V20, DOI 10.1186/s12916-022-02474-2
   Namazi MR, 2011, J AM ACAD DERMATOL, V64, P1175, DOI 10.1016/j.jaad.2010.04.022
   nce B., 2020, TURK PSIKIYATR DERG, V31, P225
   Nielsen RE, 2021, NAT REV CARDIOL, V18, P136, DOI 10.1038/s41569-020-00463-7
   Nkondo-Ndaba MP, 2022, SAJP-S AFR J PSYCHI, V28, DOI 10.4102/sajpsychiatry.v28i0.1772
   North BJ, 2012, CIRC RES, V110, P1097, DOI 10.1161/CIRCRESAHA.111.246876
   Ortiz A, 2022, J AFFECT DISORDERS, V319, P663, DOI 10.1016/j.jad.2022.09.048
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Plans L, 2019, J AFFECT DISORDERS, V242, P111, DOI 10.1016/j.jad.2018.08.054
   Prieto ML, 2014, ACTA PSYCHIAT SCAND, V130, P342, DOI 10.1111/acps.12293
   Pyner S, 2014, EXP PHYSIOL, V99, P332, DOI 10.1113/expphysiol.2013.072678
   Rodevand L, 2021, TRANSL PSYCHIAT, V11, DOI 10.1038/s41398-021-01527-z
   Rosenblat JD, 2017, BRAIN SCI, V7, DOI 10.3390/brainsci7110144
   Roshanaei-Moghaddam B, 2009, PSYCHIAT SERV, V60, P147, DOI 10.1176/appi.ps.60.2.147
   Rossom RC, 2022, J AM HEART ASSOC, V11, DOI 10.1161/JAHA.121.021444
   Roy T, 2012, J AFFECT DISORDERS, V142, pS8, DOI 10.1016/S0165-0327(12)70004-6
   Russell G, 2019, NAT REV ENDOCRINOL, V15, P525, DOI 10.1038/s41574-019-0228-0
   Salagre E, 2017, EUR PSYCHIAT, V43, P81, DOI 10.1016/j.eurpsy.2017.02.482
   Sandercock GRH, 2005, INT J CARDIOL, V103, P238, DOI 10.1016/j.ijcard.2004.09.013
   Sengupta Gunja, 2022, Ind Psychiatry J, V31, P318, DOI 10.4103/ipj.ipj_24_21
   Silvani A, 2016, PHILOS T R SOC A, V374, DOI 10.1098/rsta.2015.0181
   Stubbs B, 2016, J AFFECT DISORDERS, V197, P259, DOI 10.1016/j.jad.2016.02.060
   Taggart P, 2013, NETH HEART J, V21, P78, DOI 10.1007/s12471-012-0365-8
   Thayer J. F., 2010, International Journal of Cardiology, V141, P122, DOI 10.1016/j.ijcard.2009.09.543
   van Weperen VYH, 2023, CLIN AUTON RES, V33, P491, DOI 10.1007/s10286-023-00948-8
   Vancampfort D, 2017, WORLD PSYCHIATRY, V16, P308, DOI 10.1002/wps.20458
   Vanhoutte PM, 2009, ACTA PHYSIOL, V196, P193, DOI 10.1111/j.1748-1716.2009.01964.x
   Vieta E, 2018, NAT REV DIS PRIMERS, V4, DOI 10.1038/nrdp.2018.8
   Vuksan-Cusa B, 2009, PSYCHIAT DANUB, V21, P382
   Weiner M, 2011, ANN CLIN PSYCHIATRY, V23, P40
   Yamaji M, 2009, CIRC-HEART FAIL, V2, P608, DOI 10.1161/CIRCHEARTFAILURE.109.868513
   Yang F, 2018, TRANSL NEUROSCI, V9, P17, DOI 10.1515/tnsci-2018-0004
   Yuan S, 2021, BMC MED, V19, DOI 10.1186/s12916-021-01977-8
NR 89
TC 2
Z9 2
U1 3
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1479-6678
EI 1744-8298
J9 FUTUR CARDIOL
JI Futur. Cardiol.
PD OCT 2
PY 2024
VL 20
IS 13
BP 709
EP 718
DI 10.1080/14796678.2024.2408944
EA OCT 2024
PG 10
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA L3Y8H
UT WOS:001329449500001
PM 39382013
DA 2025-06-11
ER

PT J
AU Zecchinati, F
   Barranco, MM
   Arana, MR
   Tocchetti, GN
   Domínguez, CJ
   Perdomo, VG
   Ruiz, ML
   Mottino, AD
   García, F
   Villanueva, SSM
AF Zecchinati, Felipe
   Manuela Barranco, Maria
   Rocio Arana, Maite
   Nicolas Tocchetti, Guillermo
   Juliana Dominguez, Camila
   Gabriela Perdomo, Virginia
   Laura Ruiz, Maria
   Domingo Mottino, Aldo
   Garcia, Fabiana
   Maris Villanueva, Silvina Stella
TI Reversion of down-regulation of intestinal multidrug
   resistance-associated protein 2 in fructose-fed rats by geraniol and
   vitamin C: Potential role of inflammatory response and oxidative stress
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Fructose-rich diet; Metabolic syndrome; Insulin resistance; Intestine;
   Mrp2; Oxidative stress; Inflammation
ID VIVO INSULIN-RESISTANCE; METABOLIC SYNDROME; SUPEROXIDE-DISMUTASE;
   ANTIOXIDANT STATUS; RICH DIET; EXPRESSION; LIVER; PREVENTS;
   FRUCTOKINASE; INVOLVEMENT
AB Intestinal multidrug resistance-associated protein 2 is an ABC transporter that limits the absorption of xenobiotics ingested orally, thus acting as essential component of the intestinal biochemical barrier. Metabolic Syndrome (MetS) is a pathological condition characterized by dyslipidemia, hyperinsulinemia, insulin resistance, chronic inflammation, and oxidative stress (OS). In a previous study we demonstrated that MetS-like conditions induced by fructose in drinking water (10% v/v, during 21 days), significantly reduced the expression and activity of intestinal Mrp2 in rats. We here evaluated the potential beneficial effect of geraniol or vitamin C supplementation, natural compounds with anti-inflammatory and anti-oxidant properties, in reverse fructose-induced Mrp2 alterations. After MetS-like conditions were induced (21 days), animals were cotreated with geraniol or vitamin C or vehicle for another 14 days. Decreased expression of Mrp2 protein and mRNA due to fructose administration was reversed by geraniol and by vitamin C, consistent with restoration of Mrp2 activity evaluated in everted intestinal sacs. Concomitantly, increased intestinal IL-1 beta and IL-6 levels induced by fructose were totally and partially counterbalanced, respectively, by geraniol administration. The intestinal redox unbalance generated by fructose was improved by geraniol and vitamin C, as evidenced by decreasing lipid peroxidation products and activity of Superoxide Dismutase and by normalizing glutathione reduced/oxidized glutathione ratio. The restoration effects exhibited by geraniol and vitamin C suggest that local inflammatory response and OS generated under MetS-like conditions represent important mediators of the intestinal Mrp2 down-regulation. Additionally, both agents could be considered of potential therapeutic value to preserve Mrp2 function under MetS conditions. (C) 2019 Published by Elsevier Inc.
C1 [Zecchinati, Felipe; Rocio Arana, Maite; Nicolas Tocchetti, Guillermo; Juliana Dominguez, Camila; Laura Ruiz, Maria; Domingo Mottino, Aldo; Maris Villanueva, Silvina Stella] Univ Nacl Rosario, Inst Fisiol Expt IFISE CONICET, Fac Ciencias Bioquim & Farmaceut, Rosario, Santa Fe, Argentina.
   [Manuela Barranco, Maria; Garcia, Fabiana] Univ Nacl Rosario, CONICET, Fac Ciencias Med, Lab Fisiol Metab, Rosario, Santa Fe, Argentina.
   [Gabriela Perdomo, Virginia] Univ Nacl Rosario, Inst Biol Mol & Celular Rosario IBR CONICET, Fac Ciencias Bioquim & Farmaceut, Rosario, Santa Fe, Argentina.
C3 National University of Rosario; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); National University of Rosario;
   National University of Rosario; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET)
RP Villanueva, SSM (corresponding author), UNR, CONICET, Inst Fisiol Expt, Fac Ciencias Bioquim & Farmaceut, Suipacha 570, RA-2000 Rosario, Santa Fe, Argentina.
EM villanueva@ifise-conicet.gov.ar
RI Perdomo, Virginia/JMP-4098-2023
OI Tocchetti, Guillermo Nicolas/0000-0003-3884-0980; Perdomo, Virginia
   Gabriela/0009-0006-3087-7630
FU Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
   [PIP 2015-0202]; Fondo para la Investigacion Cientifica y Tecnologica
   (FONCyT) [PICT 2014-1121, PICT 2014-0476]
FX This study was supported by grants from: Consejo Nacional de
   Investigaciones Cientificas y Tecnicas (CONICET) [PIP 2015-0202], Fondo
   para la Investigacion Cientifica y Tecnologica (FONCyT) [PICT 2014-1121
   (to S.S.M.V.) and PICT 2014-0476 (to A.D.M.)].
CR Abdali D, 2015, MED PRIN PRACT, V24, P201, DOI 10.1159/000375305
   Ando K, 2009, FREE RADICAL BIO MED, V47, P213, DOI 10.1016/j.freeradbiomed.2009.04.030
   Aydin S, 2014, NUTRITION, V30, P1, DOI 10.1016/j.nut.2013.05.013
   Babukumar S, 2017, PHARM BIOL, V55, P1442, DOI 10.1080/13880209.2017.1301494
   BEAUCHAM.C, 1971, ANAL BIOCHEM, V44, P276, DOI 10.1016/0003-2697(71)90370-8
   Beltrán-Sánchez H, 2013, J AM COLL CARDIOL, V62, P697, DOI 10.1016/j.jacc.2013.05.064
   Bray GA, 2004, AM J CLIN NUTR, V79, P537
   CARRILLO MC, 1994, LIFE SCI, V54, P975, DOI 10.1016/0024-3205(94)00499-4
   Castro MC, 2012, CLIN SCI, V123, P681, DOI 10.1042/CS20110665
   Chen J, 2016, J GASTROEN HEPATOL, V31, P1357, DOI 10.1111/jgh.13272
   Choi JS, 2004, J NUTR, V134, P1013, DOI 10.1093/jn/134.5.1013
   Cigliano L, 2018, MOL NEUROBIOL, V55, P2869, DOI 10.1007/s12035-017-0518-2
   DAVISON AJ, 1986, J BIOL CHEM, V261, P1193
   Delbosc S, 2005, ATHEROSCLEROSIS, V179, P43, DOI 10.1016/j.atherosclerosis.2004.10.018
   Dietrich CG, 2004, GASTROENTEROLOGY, V126, P1044, DOI 10.1053/j.gastro.2003.12.046
   Donahue JL, 1997, PLANT PHYSIOL, V113, P249, DOI 10.1104/pp.113.1.249
   Ellulu MS, 2017, INFLAMMOPHARMACOLOGY, V25, P313, DOI 10.1007/s10787-017-0314-7
   Faure P, 1997, J NUTR, V127, P103, DOI 10.1093/jn/127.1.103
   Faure P, 1999, DIABETES, V48, P353, DOI 10.2337/diabetes.48.2.353
   Frazier Thomas H, 2011, JPEN J Parenter Enteral Nutr, V35, p14S, DOI 10.1177/0148607111413772
   Garcia-Bailo B, 2011, BIOL-TARGETS THER, V5, P7, DOI 10.2147/BTT.S14417
   Geier A, 2003, BIOCHEM BIOPH RES CO, V309, P612, DOI 10.1016/j.bbrc.2003.08.041
   Godala MM, 2016, ADV CLIN EXP MED, V25, P689, DOI 10.17219/acem/41049
   GRIFFITH OW, 1980, ANAL BIOCHEM, V106, P207, DOI 10.1016/0003-2697(80)90139-6
   Ibrahim SM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0117516
   Incir S, 2016, LIFE SCI, V158, P57, DOI 10.1016/j.lfs.2016.06.014
   Ishimoto T, 2012, P NATL ACAD SCI USA, V109, P4320, DOI 10.1073/pnas.1119908109
   Iwata N, 2014, NUTRIENTS, V6, P1554, DOI 10.3390/nu6041554
   Jang IS, 2014, ASIAN AUSTRAL J ANIM, V27, P749, DOI 10.5713/ajas.2013.13852
   Ji B, 2004, FREE RADICAL BIO MED, V37, P1718, DOI 10.1016/j.freeradbiomed.2004.08.020
   Ji P, 2002, TRANSPLANT P, V34, P1418, DOI 10.1016/S0041-1345(02)02910-X
   Johnson RJ, 2013, J EQUINE VET SCI, V33, P120, DOI 10.1016/j.jevs.2012.05.004
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Li YR, 2013, ASIA PAC J CLIN NUTR, V22, P60, DOI 10.6133/apjcn.2013.22.1.06
   Lim JS, 2010, NAT REV GASTRO HEPAT, V7, P251, DOI 10.1038/nrgastro.2010.41
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   Maiztegui B, 2011, CLIN SCI, V120, P73, DOI 10.1042/CS20100372
   Marcuzzi A, 2011, IN VIVO, V25, P87
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Miller A, 2008, CURR OPIN GASTROEN, V24, P204, DOI 10.1097/MOG.0b013e3282f3f4c4
   Mottino AD, 2000, J PHARMACOL EXP THER, V293, P717
   Mottino AD, 2001, AM J PHYSIOL-GASTR L, V280, pG1261, DOI 10.1152/ajpgi.2001.280.6.G1261
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   Panchal SK, 2011, J BIOMED BIOTECHNOL, DOI 10.1155/2011/351982
   Park S, 2015, NUTRITION, V31, P111, DOI 10.1016/j.nut.2014.05.011
   Prince PD, 2016, FREE RADICAL BIO MED, V90, P35, DOI 10.1016/j.freeradbiomed.2015.11.009
   Rodrigues DF, 2014, J NUTR BIOCHEM, V25, P388, DOI 10.1016/j.jnutbio.2013.11.012
   Rosas-Villegas A, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040393
   Satoh H, 2004, J CLIN INVEST, V114, P224, DOI 10.1172/JCI200420785
   Sekine S, 2010, BIOCHEM BIOPH RES CO, V399, P279, DOI 10.1016/j.bbrc.2010.07.069
   Sellmann C, 2015, J NUTR BIOCHEM, V26, P1183, DOI 10.1016/j.jnutbio.2015.05.011
   Londero AS, 2017, J NUTR BIOCHEM, V40, P178, DOI 10.1016/j.jnutbio.2016.11.002
   Soubh AA, 2015, LIFE SCI, V136, P142, DOI 10.1016/j.lfs.2015.07.004
   Spruss A, 2012, LAB INVEST, V92, P1020, DOI 10.1038/labinvest.2012.75
   Suzuki H, 2000, EUR J PHARM SCI, V12, P3, DOI 10.1016/S0928-0987(00)00178-0
   Tappy L, 2010, PHYSIOL REV, V90, P23, DOI 10.1152/physrev.00019.2009
   THORBURN AW, 1989, AM J CLIN NUTR, V49, P1155, DOI 10.1093/ajcn/49.6.1155
   Tiwari M, 2009, TOXICOL IN VITRO, V23, P295, DOI 10.1016/j.tiv.2008.12.014
   Trauner M, 1997, GASTROENTEROLOGY, V113, P255, DOI 10.1016/S0016-5085(97)70103-3
   Villanueva SSM, 2010, J PHARMACOL EXP THER, V335, P332, DOI 10.1124/jpet.110.171041
   Vinothkumar V, 2012, MOL CELL BIOCHEM, V369, P17, DOI 10.1007/s11010-012-1364-1
   Wei YR, 2007, J NUTR BIOCHEM, V18, P1, DOI 10.1016/j.jnutbio.2006.03.013
   Zhang DM, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040335
   Zhou J, 2011, JPEN-PARENTER ENTER, V35, P158, DOI 10.1177/0148607110388943
NR 64
TC 13
Z9 15
U1 0
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD JUN
PY 2019
VL 68
BP 7
EP 15
DI 10.1016/j.jnutbio.2019.03.002
PG 9
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA ID5SR
UT WOS:000471736800002
PM 31005848
OA Green Published
DA 2025-06-11
ER

PT J
AU Alifu, J
   Xu, B
   Tuersun, G
   Liu, L
   Xiang, LQ
   Mohammed, AQ
   Zhang, W
   Yin, GQ
   Wang, CY
   Lv, X
   Shi, TT
   Wu, Q
   Abdu, FA
   Che, WL
AF Alifu, Jiasuer
   Xu, Bin
   Tuersun, Guliziba
   Liu, Lu
   Xiang, Lanqing
   Mohammed, Abdul-Quddus
   Zhang, Wen
   Yin, Guoqing
   Wang, Chunyue
   Lv, Xian
   Shi, Tingting
   Wu, Qian
   Abdu, Fuad A.
   Che, Wenliang
TI The prognostic significance of stress hyperglycemia ratio for all-cause
   and cardiovascular mortality in metabolic syndrome patients: prospective
   cohort study
SO ACTA DIABETOLOGICA
LA English
DT Article
DE Metabolic syndrome; Stress hyperglycemia ratio; Mortality; NHANES
ID MYOCARDIAL-INFARCTION; RISK; EVENTS
AB Objective The stress hyperglycemia ratio (SHR) is a new biomarker indicating acute hyperglycemia and predicting adverse outcomes in different conditions. Yet, its impact on metabolic syndrome (MetS) has not been studied. We explored the link between SHR and long-term all-cause and cardiovascular disease (CVD) mortality in MetS patients. Methods We conducted a large prospective cohort study involving 9438 participants diagnosed with MetS, drawn from the 1999-2018 NHANES. MetS diagnosis was based on NCEP-ATPIII criteria. Participants were categorized into three groups based on SHR tertiles: T1 (SHR <= 0.890), T2 (SHR 0.890-0.992), and T3 (SHR >= 0.992). Cox regression and Kaplan-Meier curve analyses assessed the correlation between SHR and mortalities. Non-linear correlations were explored using restricted cubic splines, and stratification analysis was performed. Results Out of 9438 MetS patients, 1929 deaths occurred during an average follow-up of 107 +/- 64 months, including 541 CVD deaths. All-cause and CVD mortality rates were significantly higher with elevated SHR values (T3) than lower tertiles (23.4% vs. 19.5% and 18.3%, P < 0.001; 6.8% vs. 5.3% and 5.1%, P = 0.007, respectively). A U-shaped relationship was observed between SHR and all-cause and CVD mortality (all P for non-linear < 0.001). Kaplan-Meier analysis indicated higher SHR values associated with increased risk of all-cause and CVD mortality (all log-rank P < 0.001). After adjusting for confounders, multivariate Cox regression showed SHR remained associated with a 1.256-fold and 1.023-fold risk of all-cause and CVD mortality. Conclusions SHR independently correlates with all-cause and CVD mortality in MetS patients, displaying a U-shaped relationship with clinical endpoints.
C1 [Alifu, Jiasuer; Xu, Bin; Liu, Lu; Xiang, Lanqing; Mohammed, Abdul-Quddus; Zhang, Wen; Yin, Guoqing; Wang, Chunyue; Lv, Xian; Shi, Tingting; Abdu, Fuad A.; Che, Wenliang] Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Cardiol, 301 Yanchang Rd, Shanghai 200072, Peoples R China.
   [Xu, Bin] Fudan Univ, Shanghai Xuhui Cent Hosp, Zhongshan Xuhui Hosp, Dept Cardiol, Shanghai, Peoples R China.
   [Tuersun, Guliziba] Peoples Hosp Xinjiang Uygur Autonomous Reg, Xinjiang Clin Res Ctr Dermatol & Venereol, Dept Dermatol & Venereol, Xinjiang Key Lab Dermatol Res, Urumqi, Xinjiang, Peoples R China.
   [Xiang, Lanqing] Nanjing Med Univ, Clin Med Coll, Shanghai Peoples Hosp 10, Dept Cardiol, Shanghai, Peoples R China.
   [Wu, Qian] Soochow Univ, Affiliated Hosp 1, Orthoped Inst, Dept Orthoped Surg, 188 Shizijie Rd, Suzhou 215006, Jiangsu, Peoples R China.
   [Wu, Qian] Jeonbuk Natl Univ, Med Sch, Res Inst Clin Med, Jeonju, South Korea.
   [Che, Wenliang] Shanghai Tenth Peoples Hosp, Chongming Branch, Dept Cardiol, Shanghai, Peoples R China.
C3 Tongji University; Fudan University; Nanjing Medical University; Soochow
   University - China; Jeonbuk National University
RP Abdu, FA; Che, WL (corresponding author), Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Cardiol, 301 Yanchang Rd, Shanghai 200072, Peoples R China.; Wu, Q (corresponding author), Soochow Univ, Affiliated Hosp 1, Orthoped Inst, Dept Orthoped Surg, 188 Shizijie Rd, Suzhou 215006, Jiangsu, Peoples R China.; Wu, Q (corresponding author), Jeonbuk Natl Univ, Med Sch, Res Inst Clin Med, Jeonju, South Korea.; Che, WL (corresponding author), Shanghai Tenth Peoples Hosp, Chongming Branch, Dept Cardiol, Shanghai, Peoples R China.
EM qianwujoint@163.com; 1691026@tongji.edu.cn; chewenliang@tongji.edu.cn
RI MOHAMMED, ABDUL QUDDUS/KBA-9659-2024; Wu, Qian/KVB-0410-2024
OI Wu, Qian/0000-0002-3986-6042
FU Chinese National Natural Science Foundation
FX The authors are indebted to all members who contributed to the NHANES
   study.
CR Abdu FA, 2023, CARDIOVASC DIABETOL, V22, DOI 10.1186/s12933-023-01742-6
   Capes SE, 2000, LANCET, V355, P773, DOI 10.1016/S0140-6736(99)08415-9
   Capes SE, 2001, STROKE, V32, P2426, DOI 10.1161/hs1001.096194
   Dungan KM, 2009, LANCET, V373, P1798, DOI 10.1016/S0140-6736(09)60553-5
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Guembe MJ, 2020, CARDIOVASC DIABETOL, V19, DOI 10.1186/s12933-020-01166-6
   Levantesi G, 2005, J AM COLL CARDIOL, V46, P277, DOI 10.1016/j.jacc.2005.03.062
   Lin ZH, 2023, CARDIOVASC DIABETOL, V22, DOI 10.1186/s12933-023-01799-3
   Liu QJ, 2024, CARDIOVASC DIABETOL, V23, DOI 10.1186/s12933-024-02152-y
   Liu QJ, 2022, AM J NEPHROL, V53, P614, DOI 10.1159/000525733
   Marenzi G, 2018, DIABETES CARE, V41, P847, DOI 10.2337/dc17-1732
   Marik PE, 2013, CRIT CARE, V17, DOI 10.1186/cc12514
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   Park S, 2021, J AM SOC NEPHROL, V32, P2595, DOI 10.1681/ASN.2020121694
   Plummer MP, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0165923
   Polovina M, 2018, EUR HEART J, V39, P4030, DOI 10.1093/eurheartj/ehy446
   Raimi TH, 2021, METAB SYNDR RELAT D, V19, P76, DOI 10.1089/met.2020.0092
   Roberts GW, 2015, J CLIN ENDOCR METAB, V100, P4490, DOI 10.1210/jc.2015-2660
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sia CH, 2021, CARDIOVASC DIABETOL, V20, DOI 10.1186/s12933-021-01395-3
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Song YJ, 2023, CARDIOVASC DIABETOL, V22, DOI 10.1186/s12933-023-01883-8
   Wang M, 2023, CARDIOVASC DIABETOL, V22, DOI 10.1186/s12933-023-01790-y
   Wang XS, 2022, DIABETES CARE, V45, P1438, DOI 10.2337/dc21-1682
   Wang YL, 2023, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.954916
   Wassink AMJ, 2008, EUR HEART J, V29, P213, DOI 10.1093/eurheartj/ehm582
   Xu W, 2022, CARDIOVASC DIABETOL, V21, DOI 10.1186/s12933-022-01479-8
   Yang HY, 2023, GYNECOL ENDOCRINOL, V39, DOI 10.1080/09513590.2023.2172154
   Yang J, 2022, DIABETES CARE, V45, P947, DOI 10.2337/dc21-1526
   Yun HR, 2018, AM J KIDNEY DIS, V72, P400, DOI 10.1053/j.ajkd.2018.02.362
   Zhang C, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1111026
   Zhang LJ, 2023, HORM-INT J ENDOCRINO, V22, P263, DOI 10.1007/s42000-023-00438-6
   Zhao Y, 2023, J TRANSL MED, V21, DOI 10.1186/s12967-023-04491-y
   Zhou Q, 2023, CARDIOVASC DIABETOL, V22, DOI 10.1186/s12933-023-01908-2
NR 34
TC 2
Z9 2
U1 4
U2 6
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD JUN
PY 2025
VL 62
IS 6
BP 903
EP 913
DI 10.1007/s00592-024-02407-w
EA NOV 2024
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 3LJ0U
UT WOS:001350904500003
PM 39508855
DA 2025-06-11
ER

PT J
AU Reijrink, M
   De Boer, SA
   Van Roon, AM
   Slart, RHJA
   Fernandez, BO
   Feelisch, M
   Heerspink, HJL
   Van Goor, H
   Hillebrands, JL
   Mulder, DJ
AF Reijrink, Melanie
   De Boer, Stefanie A.
   Van Roon, Anniek M.
   Slart, Riemer H. J. A.
   Fernandez, Bernadette O.
   Feelisch, Martin
   Heerspink, Hiddo J. L.
   Van Goor, Harry
   Hillebrands, Jan-Luuk
   Mulder, Douwe J.
TI Plasma Nitrate Levels Are Related to Metabolic Syndrome and Are Not
   Altered by Treatment with DPP-4 Inhibitor Linagliptin: A Randomised,
   Placebo-Controlled Trial in Patients with Early Type 2 Diabetes Mellitus
SO ANTIOXIDANTS
LA English
DT Article
DE diabetes; inflammation; linagliptin; metabolic syndrome; nitrate; nitric
   oxide; oxidative stress; vegetable intake
ID NITRIC-OXIDE; OXIDATIVE STRESS; INSULIN-RESISTANCE; ADIPOSE-TISSUE;
   ARTERIAL STIFFNESS; DIETARY NITRITE; INFLAMMATION; OBESITY;
   COMPLICATIONS; PATHOGENESIS
AB The depletion of nitrate and nitrite, stable nitric oxide (NO) end-products, promotes adipose tissue dysfunction and insulin resistance (IR). Dipeptidyl peptidase-4 (DPP-4) inhibitors have the potentially beneficial side effect of increasing NO availability. In this study, nitrate and nitrite levels and the effects of DPP-4 inhibitor linagliptin were investigated in relation to metabolic syndrome (MetS) markers. Treatment-naive patients with early type 2 diabetes mellitus (T2DM) (n = 40, median age 63 IQR (55-67) years, 63% male, mean HbA1c 45 +/- 4.4 mmol/mol) were randomized (1:1) to linagliptin (5 mg/day) or placebo. MetS-related markers (body mass index (BMI), triglycerides, HOMA-IR, gamma-glutamyltransferase (GGT), C-reactive protein (CRP), and adiponectin), plasma levels of nitrate, nitrite, total free thiols (TFT) and vegetable intake were estimated at baseline and after 4 and 26 weeks of treatment. Plasma nitrate, but not nitrite, correlated positively with vegetable intake (r = 0.38, p = 0.018) and was inversely associated with HOMA-IR (r = -0.44, p = 0.006), BMI (r = -0.35, p = 0.028), GGT (r = -0.37, p = 0.019) and CRP (r = -0.34, p = 0.034). The relationship between nitrate and HOMA-IR remained significant after adjusting for BMI, CRP, vegetable intake and GGT. With stable vegetable intake, nitrate and nitrite, TFT, adipokines and CRP did not change after 26 weeks of linagliptin treatment. While plasma nitrate is inversely associated with MetS, linagliptin treatment does not significantly influence nitrate and nitrite concentrations, oxidative stress, adipose tissue function and systemic inflammation.
C1 [Reijrink, Melanie; De Boer, Stefanie A.; Van Roon, Anniek M.; Mulder, Douwe J.] Univ Groningen, Div Vasc Med, Dept Internal Med, Med Ctr Groningen, NL-9713 Groningen, Netherlands.
   [Slart, Riemer H. J. A.] Univ Groningen, Dept Nucl Med & Mol Imaging, Med Ctr Groningen, NL-9713 Groningen, Netherlands.
   [Slart, Riemer H. J. A.] Univ Twente, Dept Biomed Photoacust Imaging BMPI, NL-7522 Enschede, Netherlands.
   [Fernandez, Bernadette O.; Feelisch, Martin] Univ Southampton, Fac Med Clin & Expt Sci, Southampton SO17 1BJ, Hants, England.
   [Heerspink, Hiddo J. L.] Univ Groningen, Dept Clin Pharm & Pharmacol, Med Ctr Groningen, NL-9713 Groningen, Netherlands.
   [Van Goor, Harry; Hillebrands, Jan-Luuk] Univ Groningen, Div Pathol, Dept Pathol & Med Biol, Med Ctr Groningen, NL-9713 Groningen, Netherlands.
C3 University of Groningen; University of Groningen; University of
   Southampton; University of Groningen; University of Groningen
RP Mulder, DJ (corresponding author), Univ Groningen, Div Vasc Med, Dept Internal Med, Med Ctr Groningen, NL-9713 Groningen, Netherlands.
EM r.h.j.a.slart@umcg.nl; h.j.lambers.heerspink@umcg.nl
RI van+Goor, Harry/AAS-7712-2020; Fernandez, Bernadette/AAG-7202-2020;
   Feelisch, Martin/C-3042-2008; Lambers Heerspink, Hiddo/K-3358-2014
OI van Goor, Harry/0000-0002-6670-1577; de Boer,
   Stefanie/0000-0002-7532-2536; Feelisch, Martin/0000-0003-2320-1158;
   Fernandez, Bernadette/0000-0001-6337-0381; Mulder,
   Douwe/0000-0003-3715-6474; Lambers Heerspink, Hiddo/0000-0002-3126-3730;
   Slart, Riemer/0000-0002-5565-1164; Reijrink, Melanie/0000-0001-9447-7333
FU Boehringer Ingelheim (Alkmaar, the Netherlands); MD/PhD program of the
   Graduate School of Medical Sciences (GSMS), University Medical Centre
   Groningen
FX This study was supported by Boehringer Ingelheim (Alkmaar, the
   Netherlands). Boehringer Ingelheim was not involved in the design and
   results of the study; collection, management, analysis and
   interpretation of data, writing of the report or the decision to submit
   the paper for publication. M.R. was supported by the MD/PhD program of
   the Graduate School of Medical Sciences (GSMS), University Medical
   Centre Groningen.
CR Abdulle AE, 2020, BMC MED, V18, DOI 10.1186/s12916-020-01587-w
   Alam MA, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/s13098-015-0095-3
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Albrecht EWJA, 2002, AM J TRANSPLANT, V2, P448, DOI 10.1034/j.1600-6143.2002.20509.x
   Assmann TS, 2016, NITRIC OXIDE-BIOL CH, V61, P1, DOI 10.1016/j.niox.2016.09.009
   Basu A, 2007, AM J PHYSIOL-ENDOC M, V293, pE1289, DOI 10.1152/ajpendo.00373.2007
   Belo VA, 2013, INT J OBESITY, V37, P740, DOI 10.1038/ijo.2012.104
   Bergmark BA, 2017, DIABETES OBES METAB, V19, P962, DOI 10.1111/dom.12905
   Bigagli E, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9030233
   de Boer SA, 2020, DIABETES OBES METAB, V22, P1220, DOI 10.1111/dom.14024
   Butler AR, 2008, CIRCULATION, V117, P2151, DOI 10.1161/CIRCULATIONAHA.107.753814
   de Boer SA, 2017, DIABETES OBES METAB, V19, P1147, DOI 10.1111/dom.12925
   de Boer SA, 2017, J AM COLL CARDIOL, V69, P1097, DOI 10.1016/j.jacc.2016.12.018
   de Boer SA, 2016, DIABETES CARE, V39, P1440, DOI 10.2337/dc16-0327
   Deb N., 2017, INT J RES MED SCI, V5, P231, DOI [10.18203/2320-6012.ijrms20164555, DOI 10.18203/2320-6012.IJRMS20164555]
   Fasshauer M, 2015, TRENDS PHARMACOL SCI, V36, P461, DOI 10.1016/j.tips.2015.04.014
   Förstermann U, 2017, CIRC RES, V120, P713, DOI 10.1161/CIRCRESAHA.116.309326
   Folli F, 2011, CURR DIABETES REV, V7, P313, DOI 10.2174/157339911797415585
   Friedman J, 2002, NATURE, V415, P268, DOI 10.1038/415268a
   Frühbeck G, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-06997-0
   Ghasemi A, 2017, NITRIC OXIDE-BIOL CH, V70, P9, DOI 10.1016/j.niox.2017.08.003
   Glorie L, 2016, BONE, V92, P37, DOI 10.1016/j.bone.2016.08.009
   Goossens GH, 2017, OBESITY FACTS, V10, P207, DOI 10.1159/000471488
   Herder C, 2007, J CLIN ENDOCR METAB, V92, P4569, DOI 10.1210/jc.2007-0955
   Ida S, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-016-0468-4
   Jackson JK, 2018, NUTRIENTS, V10, DOI 10.3390/nu10081005
   Karam BS, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-017-0604-9
   Kina-Tanada M, 2017, DIABETOLOGIA, V60, P1138, DOI 10.1007/s00125-017-4259-6
   Koning AM, 2016, PHARMACOL RES, V111, P452, DOI 10.1016/j.phrs.2016.06.027
   Koren S, 2012, DIABETES TECHNOL THE, V14, P561, DOI 10.1089/dia.2011.0296
   Lamers D, 2011, DIABETES, V60, P1917, DOI 10.2337/db10-1707
   Levey AS, 2009, ANN INTERN MED, V150, P604, DOI 10.7326/0003-4819-150-9-200905050-00006
   Li T, 2016, FOOD NUTR RES, V60, DOI 10.3402/fnr.v60.32010
   Luc K, 2019, J PHYSIOL PHARMACOL, V70, P809, DOI 10.26402/jpp.2019.6.01
   Lundberg JO, 2008, NAT REV DRUG DISCOV, V7, DOI [10.1038/nrd2466-c2, 10.1038/nrd2466]
   Lundberg JO, 2018, CELL METAB, V28, P9, DOI 10.1016/j.cmet.2018.06.007
   Makino H, 2019, DIABETOL INT, V10, P148, DOI 10.1007/s13340-018-0376-9
   Marchi-Alves LM, 2009, CARDIOL RES PRACT, V2009, DOI 10.4061/2009/376735
   Mason RP, 2011, J ATHEROSCLER THROMB, V18, P774, DOI 10.5551/jat.7666
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Nácul AP, 2007, EUR J OBSTET GYN R B, V133, P191, DOI 10.1016/j.ejogrb.2006.09.009
   Norouzirad R, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/5350267
   Ohtake K, 2015, NITRIC OXIDE-BIOL CH, V44, P31, DOI 10.1016/j.niox.2014.11.009
   Ozgen IT, 2012, J PEDIATR ENDOCR MET, V25, P261, DOI 10.1515/jpem-2011-0397
   Punthakee Z, 2018, CAN J DIABETES, V42, pS10, DOI 10.1016/j.jcjd.2017.10.003
   Rassaf T, 2002, FREE RADICAL BIO MED, V33, P1590, DOI 10.1016/S0891-5849(02)01183-8
   Rehman K, 2017, J CELL BIOCHEM, V118, P3577, DOI 10.1002/jcb.26097
   Rizzo M, 2009, EXPERT OPIN INV DRUG, V18, P1495, DOI 10.1517/14728220903241633
   Schrover IM, 2016, HORM METAB RES, V48, P213, DOI 10.1055/s-0042-103243
   Solini A, 2016, VASC PHARMACOL, V76, P62, DOI 10.1016/j.vph.2015.10.002
   Umbrello M, 2014, J PHYSIOL-LONDON, V592, P1061, DOI 10.1113/jphysiol.2013.255687
   van den Born JC, 2016, DIABETES, V65, P331, DOI 10.2337/db15-1003
   Varzandi T, 2018, LIFE SCI, V207, P219, DOI 10.1016/j.lfs.2018.06.012
   Vos T., 2017, LANCET, V390, P1211
NR 54
TC 2
Z9 2
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD OCT
PY 2021
VL 10
IS 10
AR 1548
DI 10.3390/antiox10101548
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA WO4GU
UT WOS:000712415300001
PM 34679685
OA Green Accepted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Puchau, B
   Zulet, MA
   de Echávarri, AG
   Hermsdorff, HHM
   Martínez, JA
AF Puchau, Blanca
   Angeles Zulet, M.
   Gonzalez de Echavarri, Amaia
   Miranda Hermsdorff, Helen Hermana
   Alfredo Martinez, J.
TI Dietary total antioxidant capacity is negatively associated with some
   metabolic syndrome features in healthy young adults
SO NUTRITION
LA English
DT Article
DE Oxidative stress; Antioxidant intake; Inflammation; Food-frequency
   questionnaire; Systolic blood pressure; Complement factor-3; Plasminogen
   activator inhibitor-1
ID FOOD-FREQUENCY QUESTIONNAIRE; SPECIES ROS GENERATION; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; WINE CONSUMPTION; SELENIUM INTAKE; BLOOD-PRESSURE;
   FOLLOW-UP; RED WINE; PLASMA
AB Objective: Oxidative stress has been related to the development of obesity and other features accompanying chronic diseases Furthermore, dietary antioxidant intake has been suggested to protect against oxidative damage and related clinical complications Therefore, the aim of this study was to assess the potential associations among dietary total antioxidant capacity (TAC) and several early metabolic syndrome manifestations in healthy young adults.
   Methods: Anthropometric variables and blood pressure from 153 healthy subjects (20 8 +/- 27 y old) were measured Dietary intake was assessed by a validated food-frequency questionnaire and a 3-d record, which were also used to calculate TAC and to adjust by daily energy intake. Fasting blood samples were collected for measuring biochemical markers.
   Results: Dietary TAC showed positive and significant associations with fiber, folic acid, vitamin A and C. magnesium, selenium, and zinc intakes, after adjusting by sex and daily energy intake Interestingly, systolic blood pressure, serum glucose. and free fatty acids were also found to be negatively associated with dietary TAC independently of sex and daily energy intake Also, a relevant relation was found between body mass index and TAC values. Interestingly, after adjusting by sex and daily enemy intake, complement factor-3 circulating levels appeared to be negatively and significantly associated with dietary TAC, whereas blood plasminogen activator inhibitor-1 and homocysteine concentrations showed an Inverse marginally statistical trend.
   Conclusions: These data suggest that dietary TAC may be also a potential early estimate of the risk to develop metabolic syndrome features and that dietary TAC could be a useful research tool in assessing antioxidant intake (C) 2010 Elsevier Inc. All rights reserved
C1 [Puchau, Blanca; Angeles Zulet, M.; Gonzalez de Echavarri, Amaia; Miranda Hermsdorff, Helen Hermana; Alfredo Martinez, J.] Univ Navarra, Dept Nutr Food Sci Physiol & Toxicol, E-31080 Pamplona, Spain.
C3 University of Navarra
RP Martínez, JA (corresponding author), Univ Navarra, Dept Nutr Food Sci Physiol & Toxicol, E-31080 Pamplona, Spain.
RI Martinez Hernandez, J Alfredo/K-8709-2014; Zulet, M.
   Angeles/H-1317-2017; Hermsdorff, Helen Hermana Miranda/H-4525-2015
OI Martinez Hernandez, J Alfredo/0000-0001-5218-6941; Zulet, M.
   Angeles/0000-0002-3926-0892; Hermsdorff, Helen Hermana
   Miranda/0000-0002-4441-6572
FU Health Department of the Government of Navarra [22/2007]; Linea Especial
   about Nutrition, Obesity and Health [LE/97]; University of Navarra;
   Capes Foundation of the Ministry of Education of Brazil [375605-0]
FX This work was supported by the Health Department of the Government of
   Navarra (22/2007), the Linea Especial about Nutrition, Obesity and
   Health (LE/97). Ibercaja, the ADA fellowships scheme of the University
   of Navarra and The Capes Foundation of the Ministry of Education of
   Brazil (375605-0)
CR Agudo A, 2007, AM J CLIN NUTR, V85, P1634, DOI 10.1093/ajcn/85.6.1634
   Ainsworth BE, 2000, MED SCI SPORT EXER, V32, pS498, DOI 10.1097/00005768-200009001-00009
   Delfino VDA, 2007, NUTRITION, V23, P242, DOI 10.1016/j.nut.2007.01.002
   Zulet MA, 2009, NUTR RES, V29, P41, DOI 10.1016/j.nutres.2008.11.003
   [Anonymous], 2005, Principles of nutritional assessment
   Appel LJ, 2006, HYPERTENSION, V47, P296, DOI 10.1161/01.HYP.0000202568.01167.B6
   Asehnoune K, 2004, J IMMUNOL, V172, P2522, DOI 10.4049/jimmunol.172.4.2522
   Hassimotto NMA, 2008, J AGR FOOD CHEM, V56, P11727, DOI 10.1021/jf8026149
   BENATAR SR, 2004, WORLD MED J, V50, P11
   Brighenti F, 2005, BRIT J NUTR, V93, P619, DOI 10.1079/BJN20051400
   Brown DM, 2004, AM J PHYSIOL-LUNG C, V286, pL344, DOI 10.1152/ajplung.00139.2003
   Carlsohn A, 2008, ANN NUTR METAB, V53, P96, DOI 10.1159/000165357
   Cianflone K, 2003, BBA-BIOMEMBRANES, V1609, P127, DOI 10.1016/S0005-2736(02)00686-7
   Crujeiras AB, 2007, FREE RADICAL RES, V41, P498, DOI 10.1080/10715760601131935
   Crujeiras AB, 2006, NUTRITION, V22, P593, DOI 10.1016/j.nut.2006.03.008
   Dandona P, 2004, TRENDS IMMUNOL, V25, P4, DOI 10.1016/j.it.2003.10.013
   Dandona P, 2001, J CLIN ENDOCR METAB, V86, P2899, DOI 10.1210/jc.86.6.2899
   Dauchet L, 2007, AM J CLIN NUTR, V85, P1650, DOI 10.1093/ajcn/85.6.1650
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Fulop T, 2006, PATHOL BIOL, V54, P375, DOI 10.1016/j.patbio.2006.07.002
   Galan P, 2005, EUR J CLIN NUTR, V59, P1181, DOI 10.1038/sj.ejcn.1602230
   Halvorsen BL, 2006, AM J CLIN NUTR, V84, P95, DOI 10.1093/ajcn/84.1.95
   Halvorsen BL, 2002, J NUTR, V132, P461, DOI 10.1093/jn/132.3.461
   KABASAKALIS A, 2008, J SCI MED SPORT
   Koh KK, 2009, CARDIOVASC RES, V81, P649, DOI 10.1093/cvr/cvn354
   Maehira F, 2003, CLIN CHIM ACTA, V334, P163, DOI 10.1016/S0009-8981(03)00223-7
   Martínez-González MA, 2005, PUBLIC HEALTH NUTR, V8, P920, DOI 10.1079/PHN2005745
   MARTINMORENO JM, 1993, INT J EPIDEMIOL, V22, P512, DOI 10.1093/ije/22.3.512
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   MAXWELL S, 1994, LANCET, V344, P193, DOI 10.1016/S0140-6736(94)92795-2
   Modun D, 2008, ATHEROSCLEROSIS, V197, P250, DOI 10.1016/j.atherosclerosis.2007.04.002
   Mohanty P, 2000, J CLIN ENDOCR METAB, V85, P2970, DOI 10.1210/jc.85.8.2970
   Mohanty P, 2002, AM J CLIN NUTR, V75, P767, DOI 10.1093/ajcn/75.4.767
   Moreno-Aliaga MJ., 2005, Adipocytes, V1, P1
   Paolisso G, 1998, J AM GERIATR SOC, V46, P833, DOI 10.1111/j.1532-5415.1998.tb02716.x
   Pasten C, 2007, THROMB RES, V121, P59, DOI 10.1016/j.thromres.2007.02.001
   Pellegrini N, 2003, J NUTR, V133, P2812, DOI 10.1093/jn/133.9.2812
   Pellegrini N, 2007, J NUTR, V137, P93, DOI 10.1093/jn/137.1.93
   Pellegrini N, 2006, MOL NUTR FOOD RES, V50, P1030, DOI 10.1002/mnfr.200600067
   Pitsavos C, 2005, AM J CLIN NUTR, V82, P694, DOI 10.1093/ajcn/82.3.694
   Puchau B, 2009, EUR J CLIN NUTR, V63, P858, DOI 10.1038/ejcn.2008.48
   Rajdl D, 2007, PHYSIOL RES, V56, P203, DOI 10.33549/physiolres.930936
   Rautiainen S, 2008, AM J CLIN NUTR, V87, P1247, DOI 10.1093/ajcn/87.5.1247
   Ritchie SA, 2004, CLIN SCI, V107, P519, DOI 10.1042/CS20040190
   Salvatore S, 2005, J AGR FOOD CHEM, V53, P9465, DOI 10.1021/jf051806r
   Serafini M, 2004, REDOX REP, V9, P145, DOI 10.1179/135100004225004814
   Svetkey LP, 1999, ARCH INTERN MED, V159, P285, DOI 10.1001/archinte.159.3.285
   Trayhurn P, 2004, BRIT J NUTR, V92, P347, DOI 10.1079/BJN20041213
   Van Gaal LF, 2006, NATURE, V444, P875, DOI 10.1038/nature05487
   Wärnberg J, 2006, AM J CLIN NUTR, V84, P505
   Whitworth JA, 2004, CLIN EXP HYPERTENS, V26, P747, DOI 10.1081/CEH-200032152
   Zoccali C, 2003, KIDNEY INT, V63, pS65, DOI 10.1046/j.1523-1755.63.s84.50.x
   Zulet MA, 2007, NUTR HOSP, V22, P511
NR 53
TC 137
Z9 149
U1 0
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD MAY
PY 2010
VL 26
IS 5
BP 534
EP 541
DI 10.1016/j.nut.2009.06.017
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 589HY
UT WOS:000277139000011
PM 19783122
DA 2025-06-11
ER

PT J
AU Kuoch, T
   Scully, M
   Tan, HK
   Rajan, TV
   Wagner, J
AF Kuoch, Theanvy
   Scully, Mary
   Tan, Heang Kim
   Rajan, Thiruchandurai V.
   Wagner, Julie
TI The National Cambodian American Town Hall Meeting: A Community Dialogue
   on "Eat, Walk, Sleep" for Health
SO PROGRESS IN COMMUNITY HEALTH PARTNERSHIPS-RESEARCH EDUCATION AND ACTION
LA English
DT Article
DE CBPR; metabolic syndrome; refugee; Cambodian
ID REFUGEES 2 DECADES; MENTAL-HEALTH; OUTCOMES; BELIEFS
AB Background: The 2009 National Cambodian American Town Hall Meeting was a public private partnership convened to address long-term health issues related the Cambodian holocaust. Goals for participants were to dispel myths about diabetes; goals for the partnership were to build research capacity and to strengthen relationships.
   Methods: Partners collaborated on all aspects of the meeting which was held in Khmer by bridged videoconferencing in 10 sites and webinar at 5 sites across the United States over a 3-hour period. EAT, WALK, SLEEP for Health (EWS), the National Cambodian American Diabetes Project program, provided the framework for the meeting.
   Results: Pre and post surveys were completed by 323 participants. Modest improvements were seen in participants' belief that they could improve their own and their community's health, although significant barriers remained. Participants and community partners evaluated the meeting positively.
   Conclusions: The meeting is a model for other populations, and results inform future work.
C1 [Kuoch, Theanvy; Scully, Mary] Khmer Hlth Advocates, Hartford, CT 06110 USA.
   [Rajan, Thiruchandurai V.; Wagner, Julie] Univ Connecticut, Ctr Hlth, Storrs, CT USA.
   [Tan, Heang Kim] Soc New Commun Res Inc, Hlth Justice CT, New York, NY USA.
C3 University of Connecticut
RP Kuoch, T (corresponding author), Khmer Hlth Advocates, Hartford, CT 06110 USA.
CR [Anonymous], DATA SET 2005 AMERIC
   [Anonymous], 2012, UNIVERSITY OF CONNEC, V1
   [Anonymous], 2007, HEALTH EMERGENCY IN
   Chen PG, 2010, AM J PREV MED, V39, P372, DOI 10.1016/j.amepre.2010.05.021
   Glasgow RE, 1997, DIABETES CARE, V20, P556, DOI 10.2337/diacare.20.4.556
   Haley H, 2011, COMMUNITY HEALTH RES
   Hampson SE, 2000, BRIT J HEALTH PSYCH, V5, P27, DOI 10.1348/135910700168748
   Harvey JN, 2009, DIABETIC MED, V26, P5, DOI 10.1111/j.1464-5491.2008.02628.x
   Marshall GN, 2005, JAMA-J AM MED ASSOC, V294, P571, DOI 10.1001/jama.294.5.571
   Mirza M, 2012, DISABIL REHABIL, V34, P542, DOI 10.3109/09638288.2011.611211
   Stacciarini JMR, 2011, COMMUNITY MENT HLT J, V47, P489, DOI 10.1007/s10597-010-9319-z
   Wagner J, 2013, J IMMIGR MINOR HEALT, V15, P1065, DOI 10.1007/s10903-012-9715-2
   Wong EC, 2011, J IMMIGR MINOR HEALT, V13, P876, DOI 10.1007/s10903-010-9392-y
NR 13
TC 9
Z9 9
U1 0
U2 7
PU JOHNS HOPKINS UNIV PRESS
PI BALTIMORE
PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD
   21218-4363 USA
SN 1557-0541
EI 1557-055X
J9 PROG COMM HLTH PARTN
JI Prog. Community Health Partnersh.
PD WIN
PY 2014
VL 8
IS 4
BP 541
EP 547
DI 10.1353/cpr.2014.0068
PG 7
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA CD5HF
UT WOS:000351117900014
PM 25727987
DA 2025-06-11
ER

PT J
AU Karaman, A
   Aydin, H
   Geçkinli, B
   Çetinkaya, A
   Karaman, S
AF Karaman, Ali
   Aydin, Hatip
   Geckinli, Bilge
   Cetinkaya, Arda
   Karaman, Selin
TI DNA damage is increased in lymphocytes of patients with metabolic
   syndrome
SO MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
LA English
DT Article
DE Metabolic syndrome; DNA damage; Comet assay; Micronucleus assay
ID POLYCYSTIC-OVARY-SYNDROME; TYPE-2 DIABETIC-PATIENTS; POOR GLYCEMIC
   CONTROL; OXIDATIVE STRESS; LIPID-PEROXIDATION; ANTIOXIDANT CAPACITY;
   INSULIN-RESISTANCE; PERIPHERAL-BLOOD; FREE-RADICALS; ASSAY
AB We assessed DNA damage in patients with metabolic syndrome (MetS) by performing comet and micronucleus (MN) assays on peripheral blood lymphocyte cultures from study participants. 52 MetS patients and 35 age-matched healthy controls were evaluated for abdominal obesity, body-mass index (BMI), blood pressure, serum triglycerides, HbA1c, HDL-C, and fasting blood glucose levels. In addition, malondialdehyde (MDA) levels and activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were determined. Serum levels of triglycerides, HbA1c, fasting blood glucose and waist circumference, systolic blood pressure, diastolic blood pressure, and BMI of the subjects in the MetS group were significantly higher than those of the control group (for each, p < 0.001). However, the mean level of HDL-C in the MetS group was lower than in the control group (p < 0.001). In the study, the length of comet tails was significantly higher in the MetS patients (10.23 +/- 1.98, range 5.72-15.08) than in the controls (3.12 +/- 1.73, range 0.6-7.1) (p < 0.001). MN frequency was also significantly increased in MetS patients (3.68 +/- 1.27 per 1000 cells) compared to that of the control group (1.81 +/- 0.84 per 1000 cells) (p < 0.001). Micronucleated cell frequency and comet-tail length in subjects showed positive correlations with waist circumference, BMI, and plasma triglyceride levels (p < 0.01) and negative correlations with HDL-C levels (p < 0.01). Among the oxidative stress factors, MDA levels were significantly higher in MetS patients than in the controls. However, SOD and GSH-Px enzyme activities were significantly lower in the MetS group than in the controls. These findings suggest that patients with MetS have increased DNA damage and oxidative stress. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Karaman, Ali; Aydin, Hatip; Geckinli, Bilge; Cetinkaya, Arda] Istanbul Zeynep Kamil Women & Children Training &, Dept Med Genet, Istanbul, Turkey.
   [Karaman, Selin] Istanbul Dr Lutfi Kirdar Kartal Training & Res Ho, Dept Family Med, Istanbul, Turkey.
C3 Istanbul Zeynep Kamil Maternity & Children's Diseases Training &
   Research Hospital; Istanbul Kartal Dr Lutfi Kirdar Training & Research
   Hospital
RP Karaman, A (corresponding author), Istanbul Zeynep Kamil Women & Children Training &, Dept Med Genet, Istanbul, Turkey.
EM alikaramandr@hotmail.com
RI Geckinli, Bilge/AGY-3825-2022; aydin, hatip/AAE-5540-2021; CETINKAYA,
   ARDA/I-9547-2013; Karaman, Ali/V-5164-2019
OI Karaman, Ali/0000-0003-3425-2727
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Amos A F, 1997, Diabet Med, V14 Suppl 5, pS1
   Anderson D, 1998, MUTAGENESIS, V13, P67, DOI 10.1093/mutage/13.1.67
   Andreassi MG, 2008, J MOL MED, V86, P1033, DOI 10.1007/s00109-008-0358-7
   Basu S, 1998, PROSTAG LEUKOTR ESS, V58, P347, DOI 10.1016/S0952-3278(98)90070-9
   Binici DN, 2013, GENET COUNSEL, V24, P149
   BONNESTAOUREL D, 1992, BIOCHEM PHARMACOL, V44, P985, DOI 10.1016/0006-2952(92)90132-3
   Bukhari SA, 2010, MOL BIOL REP, V37, P289, DOI 10.1007/s11033-009-9686-0
   CADENAS E, 1989, ANNU REV BIOCHEM, V58, P79, DOI 10.1146/annurev.bi.58.070189.000455
   Çakatay U, 2005, DIABETES METAB, V31, P551, DOI 10.1016/S1262-3636(07)70230-6
   Ceriello A, 1997, DIABETIC MED, V14, pS45, DOI 10.1002/(SICI)1096-9136(199708)14:3+<S45::AID-DIA444>3.3.CO;2-I
   Dandona P, 1996, LANCET, V347, P444, DOI 10.1016/S0140-6736(96)90013-6
   Davi G, 2005, ANTIOXID REDOX SIGN, V7, P256, DOI 10.1089/ars.2005.7.256
   Demirbag R, 2006, INT J CLIN PRACT, V60, P1187, DOI 10.1111/j.1742-1241.2006.01042.x
   Dreher D, 1996, EUR J CANCER, V32A, P30, DOI 10.1016/0959-8049(95)00531-5
   Fenech M, 2007, NAT PROTOC, V2, P1084, DOI 10.1038/nprot.2007.77
   Goodarz M.O., 2006, BEST PRACT RES CLIN, V20, P93
   Hamurcu Z, 2010, GYNECOL ENDOCRINOL, V26, P590, DOI 10.3109/09513591003632142
   Huang PX, 2009, PREV MED, V48, P383, DOI 10.1016/j.ypmed.2008.12.023
   Hwang ES, 2007, TOXICOLOGY, V229, P1, DOI 10.1016/j.tox.2006.10.013
   Iozzo P, 2009, DIABETES CARE, V32, pS168, DOI 10.2337/dc09-S304
   JENNINGS PE, 1992, METABOLISM, V41, P36, DOI 10.1016/0026-0495(92)90093-P
   Kirsch-Volders M, 2003, MUTAT RES-GEN TOX EN, V540, P153, DOI 10.1016/j.mrgentox.2003.07.005
   Konat GW, 2003, J BIOSCIENCES, V28, P57, DOI 10.1007/BF02970132
   Lawlor DA, 2006, BMJ-BRIT MED J, V333, P1060, DOI 10.1136/bmj.333.7577.1060
   Lesgards JF, 2002, ENVIRON HEALTH PERSP, V110, P479, DOI 10.1289/ehp.02110479
   Lodovici M, 2008, MUTAT RES-FUND MOL M, V638, P98, DOI 10.1016/j.mrfmmm.2007.09.002
   Moran LJ, 2008, MUTAT RES-FUND MOL M, V639, P55, DOI 10.1016/j.mrfmmm.2007.11.007
   Ode KL, 2009, REV ENDOCR METAB DIS, V10, P167, DOI 10.1007/s11154-009-9115-7
   Oktyabrsky ON, 2007, BIOCHEMISTRY-MOSCOW+, V72, P132, DOI 10.1134/S0006297907020022
   Oranje WA, 1999, DIABETES CARE, V22, P2083, DOI 10.2337/diacare.22.12.2083
   Packer L, 2001, NUTRITION, V17, P888, DOI 10.1016/S0899-9007(01)00658-X
   PAGLIA DE, 1967, J LAB CLIN MED, V70, P158
   POMPELLA A, 1987, LIPIDS, V22, P206, DOI 10.1007/BF02537304
   Rehman A, 1999, FEBS LETT, V448, P120, DOI 10.1016/S0014-5793(99)00339-7
   Robertson RP, 2004, J BIOL CHEM, V279, P42351, DOI 10.1074/jbc.R400019200
   Ruhe RC, 2001, J AM COLL NUTR, V20, p363S, DOI 10.1080/07315724.2001.10719169
   Sena LA, 2012, MOL CELL, V48, P158, DOI 10.1016/j.molcel.2012.09.025
   SINGH NP, 1988, EXP CELL RES, V175, P184, DOI 10.1016/0014-4827(88)90265-0
   SUN Y, 1988, CLIN CHEM, V34, P497
   Mitjavila MT, 2013, CLIN NUTR, V32, P172, DOI 10.1016/j.clnu.2012.08.002
   Toperoff G, 2012, HUM MOL GENET, V21, P371, DOI 10.1093/hmg/ddr472
   Vassalle C, 2008, CLIN BIOCHEM, V41, P1162, DOI 10.1016/j.clinbiochem.2008.07.005
   Vincent HK, 2007, DIABETES OBES METAB, V9, P813, DOI 10.1111/j.1463-1326.2007.00692.x
   Yesilada E, 2006, EUR J ENDOCRINOL, V154, P563, DOI 10.1530/eje.1.02117
NR 45
TC 40
Z9 45
U1 0
U2 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1383-5718
EI 1879-3592
J9 MUTAT RES-GEN TOX EN
JI Mutat. Res. Genet. Toxicol. Environ. Mutagen.
PD APR
PY 2015
VL 782
BP 30
EP 35
DI 10.1016/j.mrgentox.2015.03.009
PG 6
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
GA CH0XW
UT WOS:000353746700005
PM 25868129
DA 2025-06-11
ER

PT J
AU de Rezende, LFM
   Rey-López, JP
   Matsudo, VKR
   Luiz, OD
AF Machado de Rezende, Leandro Fornias
   Rey-Lopez, Juan Pablo
   Rodrigues Matsudo, Victor Keihan
   Luiz, Olinda do Carmo
TI Sedentary behavior and health outcomes among older adults: a systematic
   review
SO BMC PUBLIC HEALTH
LA English
DT Review
DE Sedentary lifestyle; Sitting time; Television; Risk factors; Aged;
   Health status; Mortality
ID ASSESSED PHYSICAL-ACTIVITY; TELEVISION VIEWING TIME; SITTING TIME;
   METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; RISK; ASSOCIATIONS;
   INDICATORS; MORTALITY; OBESITY
AB Background: In the last decade, sedentary behavior has emerged as a new risk factor for health. The elderly spend most of their awake time in sedentary activities. Despite this high exposure, the impact of this sedentary behavior on the health of this population has not yet been reviewed. We systematically reviewed evidence for associations between sedentary behavior and multiple health outcomes in adults over 60 years of age.
   Methods: We searched the Medline, Embase, Web of Science, SPORTDiscus, PsycINFO, CINAHL, LILLACS, and Sedentary Research Database for observational studies published up to May 2013. Additionally, we contacted members of the Sedentary Behaviour Research Network to identify articles that were potentially eligible. After inclusion, the methodological quality of the evidence was assessed in each study.
   Results: We included 24 eligible articles in our systematic review, of which only 2 (8%) provided high-quality evidence. Greater sedentary time was related to an increased risk of all-cause mortality in the older adults. Some studies with a moderate quality of evidence indicated a relationship between sedentary behavior and metabolic syndrome, waist circumference, and overweightness/obesity. The findings for other outcomes such as mental health, renal cancer cells, and falls remain insufficient to draw conclusions.
   Conclusion: This systematic review supports the relationship between sedentary behavior and mortality in older adults. Additional studies with high methodological quality are still needed to develop informed guidelines for addressing sedentary behavior in older adults.
C1 [Machado de Rezende, Leandro Fornias; Rey-Lopez, Juan Pablo; Luiz, Olinda do Carmo] Univ Sao Paulo, Sch Med, Dept Prevent Med, Sao Paulo, Brazil.
   [Machado de Rezende, Leandro Fornias; Rodrigues Matsudo, Victor Keihan] Ctr Studies & Phys Fitness Lab Sao Caetano do Sul, Sao Caetano do Sul, SP, Brazil.
C3 Universidade de Sao Paulo
RP de Rezende, LFM (corresponding author), Univ Sao Paulo, Sch Med, Dept Prevent Med, Av Dr Arnaldo 455, Sao Paulo, Brazil.
EM lerezende@usp.br
RI Luiz, Olinda/C-6075-2012; Rezende, Leandro/C-1724-2012
OI Rezende, Leandro/0000-0002-7469-1399; Rey Lopez, Juan
   Pablo/0000-0002-7201-2006
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, Sao Paulo
   Research Foundation) [2012/07314-8]
FX We would like to thank the Sedentary Behaviour Research Network members
   for sending us titles of studies that were potentially eligible for
   inclusion in our systematic review. This study received financial
   support from the Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
   (FAPESP, Sao Paulo Research Foundation; Grant no. 2012/07314-8).
CR Altman DG, 2006, BRIT MED J, V332, P1080, DOI 10.1136/bmj.332.7549.1080
   Andrade C, 2012, ARCH INTERN MED, V172, P1272, DOI 10.1001/archinternmed.2012.2539
   Anguera JA, 2013, NATURE, V501, P97, DOI 10.1038/nature12486
   [Anonymous], 2012, OLD AM 2012 KEY IND
   [Anonymous], 2012, Good Health Adds Life to Years
   [Anonymous], 2013, Physical Activity Epidemiology
   [Anonymous], 1998, National Nutrition Survey Users' Guide 1995
   Atkin AJ, 2012, INT J EPIDEMIOL, V41, P1460, DOI 10.1093/ije/dys118
   Balboa-Castillo T, 2011, HEALTH QUAL LIFE OUT, V9, DOI 10.1186/1477-7525-9-47
   Bankoski A, 2011, DIABETES CARE, V34, P497, DOI 10.2337/dc10-0987
   Buman MP, 2010, AM J EPIDEMIOL, V172, P1155, DOI 10.1093/aje/kwq249
   Campbell PT, 2013, J CLIN ONCOL, V31, P876, DOI 10.1200/JCO.2012.45.9735
   Davis MG, 2011, MED SCI SPORT EXER, V43, P647, DOI 10.1249/MSS.0b013e3181f36196
   Dinero T E, 1996, J Health Soc Policy, V8, P63, DOI 10.1300/J045v08n01_06
   Dogra S, 2012, AGING RES, V2012
   Frank L, 2010, J PHYS ACT HEALTH, V7, pS82, DOI 10.1123/jpah.7.s1.s82
   Gabriel KKP, 2012, J PHYS ACT HEALTH, V9, pS11, DOI 10.1123/jpah.9.s1.s11
   Gao X, 2007, DIABETES CARE, V30, P694, DOI 10.2337/dc06-1835
   Gardiner PA, 2011, J AM GERIATR SOC, V59, P788, DOI 10.1111/j.1532-5415.2011.03390.x
   Geda YE, 2012, MAYO CLIN PROC, V87, P437, DOI 10.1016/j.mayocp.2011.12.020
   Geda YE, 2011, J NEUROPSYCH CLIN N, V23, P149, DOI 10.1176/appi.neuropsych.23.2.149
   Gennuso KP, 2013, MED SCI SPORT EXER, V45, P1493, DOI 10.1249/MSS.0b013e318288a1e5
   George SM, 2011, ANN EPIDEMIOL, V21, P787, DOI 10.1016/j.annepidem.2011.04.012
   Gomez-Cabello A, 2012, NUTR HOSP, V27, P865, DOI 10.3305/nh.2012.27.3.5668
   Gómez-Cabello A, 2012, MATURITAS, V73, P337, DOI 10.1016/j.maturitas.2012.09.001
   Grontved A, 2011, JAMA-J AM MED ASSOC, V305, P2448, DOI 10.1001/jama.2011.812
   Guyatt GH, 2011, J CLIN EPIDEMIOL, V64, P380, DOI 10.1016/j.jclinepi.2010.09.011
   Hallal PC, 2012, LANCET, V380, P247, DOI 10.1016/S0140-6736(12)60646-1
   Hamer M, 2012, OBESITY, V20, P2113, DOI 10.1038/oby.2012.61
   Hamer M, 2012, ARTERIOSCL THROM VAS, V32, P500, DOI 10.1161/ATVBAHA.111.236877
   Hart TL, 2011, INT J BEHAV NUTR PHY, V8, DOI 10.1186/1479-5868-8-62
   Inoue S, 2012, J EPIDEMIOL, V22, P50, DOI 10.2188/jea.JE20110054
   Katzmarzyk PT, 2010, DIABETES, V59, P2717, DOI 10.2337/db10-0822
   Kozey-Keadle S, 2011, MED SCI SPORT EXER, V43, P1561, DOI 10.1249/MSS.0b013e31820ce174
   Kueider AM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0040588
   LeBlanc AG, 2012, APPL PHYSIOL NUTR ME, V37, P753, DOI [10.1139/H2012-063, 10.1139/h2012-063]
   León-Muñoz LM, 2013, MED SCI SPORT EXER, V45, P1501, DOI 10.1249/MSS.0b013e3182897e87
   Lynch BM, 2011, EUR J CANCER CARE, V20, P514, DOI 10.1111/j.1365-2354.2010.01205.x
   Lynch BM, 2010, CANCER EPIDEM BIOMAR, V19, P2691, DOI 10.1158/1055-9965.EPI-10-0815
   Marshall SJ, 2004, INT J OBESITY, V28, P1238, DOI 10.1038/sj.ijo.0802706
   Martínez-Gómez D, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-47
   Mâsse LC, 2005, MED SCI SPORT EXER, V37, pS544, DOI 10.1249/01.mss.0000185674.09066.8a
   Matthews CE, 2008, AM J EPIDEMIOL, V167, P875, DOI 10.1093/aje/kwm390
   Nybo H, 2003, J AM GERIATR SOC, V51, P1365, DOI 10.1046/j.1532-5415.2003.51453.x
   Owen N, 2012, PREV MED, V55, P535, DOI 10.1016/j.ypmed.2012.08.024
   Owen N, 2010, EXERC SPORT SCI REV, V38, P105, DOI 10.1097/JES.0b013e3181e373a2
   Pate RR, 2008, EXERC SPORT SCI REV, V36, P173, DOI 10.1097/JES.0b013e3181877d1a
   Pavey T. G., 2015, British Journal of Sports Medicine, V49, P95, DOI 10.1136/bjsports-2012-091676
   Primack BA, 2012, AM J PREV MED, V42, P630, DOI 10.1016/j.amepre.2012.02.023
   Proper KI, 2011, AM J PREV MED, V40, P174, DOI 10.1016/j.amepre.2010.10.015
   Rhodes RE, 2012, AM J PREV MED, V42, pE3, DOI 10.1016/j.amepre.2011.10.020
   Scully T, 2012, NATURE, V492, pS2, DOI 10.1038/492S2a
   Stamatakis E, 2012, PREV MED, V54, P82, DOI 10.1016/j.ypmed.2011.10.009
   Thorp AA, 2011, AM J PREV MED, V41, P207, DOI 10.1016/j.amepre.2011.05.004
   Tremblay MS, 2011, INT J BEHAV NUTR PHY, V8, DOI 10.1186/1479-5868-8-98
   Verghese J, 2003, NEW ENGL J MED, V348, P2508, DOI 10.1056/NEJMoa022252
   Wilmot EG, 2012, DIABETOLOGIA, V55, P2895, DOI 10.1007/s00125-012-2677-z
   Wong SL, 2011, J PHYS ACT HEALTH, V8, P587, DOI 10.1123/jpah.8.4.587
   World Health Organization (WHO), 2007, Global Age-friendly Cities: A Guide
   Yudkin JS, 2011, BMJ-BRIT MED J, V343, DOI 10.1136/bmj.d7995
   ,, 2010, Global recommendations on physical activity for health
NR 61
TC 430
Z9 497
U1 12
U2 123
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD APR 9
PY 2014
VL 14
AR 333
DI 10.1186/1471-2458-14-333
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA AG5PB
UT WOS:000335469800001
PM 24712381
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Attia, GM
   Alharbi, OA
   Aljohani, RM
AF Attia, Ghalia M.
   Alharbi, Ohood A.
   Aljohani, Reema M.
TI The Impact of Irregular Menstruation on Health: A Review of the
   Literature
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE psychological and mental health; infertility; osteoporosis; anemia;
   quality of life; rheumatoid arthritis; cardiovascular diseases; type 2
   diabetes mellitus; metabolism syndrome; irregular menstruation
ID POLYCYSTIC-OVARY-SYNDROME; METABOLIC SYNDROME; CYCLE IRREGULARITY;
   ADOLESCENTS; DISORDERS; WOMEN; ASSOCIATION; RISK; UNIVERSITY; STUDENTS
AB Women are considered to have an irregular menstrual cycle if their cycle length is less than 21 days or more than 35 days, accompanied by less or very severe blood flow. The prevalence of menstrual cycle irregularities varies across countries. Irregular periods can occur due to changes in the body's levels of estrogen and progesterone hormones, which disrupt the normal pattern of the period. Menstrual irregularity has been found to be associated with various diseases and medical conditions, such as metabolic syndrome, coronary heart disease, type 2 diabetes mellitus, and rheumatoid arthritis. Anemia, osteoporosis, psychological problems, impaired quality of life, and infertility have also been recorded. Moreover, a significant correlation between irregular periods and the risk of developing pregnancy-related hypertensive disorders, as well as an increased risk of adverse obstetric and neonatal outcomes, has been proven. Therefore, irregular menstruation is considered an important health indicator among women. Physical, mental, social, psychological, and reproductive problems are often associated with menstrual irregularities. Thus, evaluating the factors associated with irregular menstruation is necessary to determine appropriate preventive and treatment strategies and to decrease the associated health problems. The aim of this review was to define normal and irregular menstruation, their types, and prevalence, to recognize the risk factors and causes of irregular menstruation, and to understand their impact on women's health.
C1 [Attia, Ghalia M.] Mansoura Univ, Med Histol & Cell Biol, Mansoura, Egypt.
   [Alharbi, Ohood A.; Aljohani, Reema M.] Taibah Univ, Coll Med, Medina, Saudi Arabia.
C3 Egyptian Knowledge Bank (EKB); Mansoura University; Taibah University
RP Alharbi, OA (corresponding author), Taibah Univ, Coll Med, Medina, Saudi Arabia.
EM ohood.alharbi99@gmail.com
OI Alharbi, Ohood/0009-0009-1567-9734
CR Abdella N., 2016, IOSR J Nurs Health Sci., V5, P1959, DOI DOI 10.9790/1959-0504021321
   Akintayo RO, 2018, EUR J RHEUMATOL, V5, P179, DOI 10.5152/eurjrheum.2018.17180
   Al Mulla A, 2022, Open J Obstet Gynecol, V12, P686, DOI [10.4236/ojog.2022.128061, DOI 10.4236/OJOG.2022.128061]
   Al-Kindi Rahma, 2011, Sultan Qaboos Univ Med J, V11, P485
   Alhammadi MH, 2022, BMC WOMENS HEALTH, V22, DOI 10.1186/s12905-022-01952-2
   Aljaroudi RA, 2019, INDO AM J PHARM SCI, V6, P3713, DOI 10.5281/zenodo.2563112
   Alpízar-Rodríguez D, 2017, RHEUMATOLOGY, V56, P1254, DOI 10.1093/rheumatology/kew318
   [Anonymous], 2021, Anemia in women and children WHO Global Anemia estimates
   Bae J, 2018, BMC WOMENS HEALTH, V18, DOI 10.1186/s12905-018-0528-x
   Barrett ES, 2014, SEMIN REPROD MED, V32, P166, DOI 10.1055/s-0034-1371088
   Bennett CJ, 2022, BRIT J NUTR, V127, P1395, DOI 10.1017/S0007114521002361
   Bonnesen B, 2016, ACTA OBSTET GYN SCAN, V95, P88, DOI 10.1111/aogs.12792
   Brantelid IE, 2014, HEALTH CARE WOMEN IN, V35, P600, DOI 10.1080/07399332.2013.868465
   Coall DA, 2016, PHILOS T R SOC B, V371, DOI 10.1098/rstb.2015.0146
   Cohrs CM, 2020, CELL REP, V31, DOI 10.1016/j.celrep.2020.03.033
   Comm Adolescent Hlth Care, 2015, OBSTET GYNECOL, V126, pe143, DOI 10.1097/AOG.0000000000001215
   Cunningham MW, 2018, AM J PHYSIOL-REG I, V315, pR521, DOI 10.1152/ajpregu.00218.2017
   Bouzas ICD, 2014, J PEDIATR ADOL GYNEC, V27, P335, DOI 10.1016/j.jpag.2014.01.002
   Dhar S, 2022, REPROD SCI, V29, P480, DOI 10.1007/s43032-021-00752-7
   Dovom MR, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0168402
   Eleftheriadou M, 2012, J PEDIATR ADOL GYNEC, V25, P172, DOI 10.1016/j.jpag.2011.11.009
   Fruscalzo A, 2010, GYNECOL ENDOCRINOL, V26, P445, DOI 10.3109/09513591003632092
   Gast GCM, 2010, FERTIL STERIL, V94, P2379, DOI 10.1016/j.fertnstert.2010.03.044
   Guembe MJ, 2020, CARDIOVASC DIABETOL, V19, DOI 10.1186/s12933-020-01166-6
   Hajivandi L, 2020, BMC PEDIATR, V20, DOI 10.1186/s12887-020-02173-y
   Handy AB, 2022, HARVARD REV PSYCHIAT, V30, P100, DOI 10.1097/HRP.0000000000000329
   Harlow SD, 2004, BJOG-INT J OBSTET GY, V111, P6, DOI 10.1111/j.1471-0528.2004.00012.x
   Harris HR, 2017, INT J CANCER, V140, P285, DOI 10.1002/ijc.30441
   Hayden MR, 2023, MEDICINA-LITHUANIA, V59, DOI 10.3390/medicina59030561
   Huang CH, 2023, J AM HEART ASSOC, V12, DOI 10.1161/JAHA.122.029020
   Hussein K, 2023, SAUDI PHARM J, V31, P1104, DOI 10.1016/j.jsps.2023.03.021
   Itriyeva K, 2022, CURR PROB PEDIATR AD, V52, DOI 10.1016/j.cppeds.2022.101241
   Jahanfar Shayesteh, 2012, Indian J Hum Genet, V18, P187, DOI 10.4103/0971-6866.100759
   Jung EK, 2018, J PSYCHOSOM OBST GYN, V39, P196, DOI 10.1080/0167482X.2017.1321631
   Kabukçu C, 2021, TAIWAN J OBSTET GYNE, V60, P311, DOI 10.1016/j.tjog.2021.01.033
   Karlsson TS, 2014, ACTA OBSTET GYN SCAN, V93, P52, DOI 10.1111/aogs.12292
   Kitaura H, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21145169
   Kwak Y, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0214071
   Kwan BS, 2022, HEALTHCARE-BASEL, V10, DOI 10.3390/healthcare10040649
   Laurindo LF, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23116193
   Lee SS, 2016, KOREAN J FAM MED, V37, P31, DOI 10.4082/kjfm.2016.37.1.31
   Magdum M., 2022, J Biosci Med, V10, P158, DOI [10.4236/jbm.2022.104014, DOI 10.4236/JBM.2022.104014]
   Mahfouz MS, 2023, OPEN MED-WARSAW, V18, DOI 10.1515/med-2023-0804
   Mahmood M, 2013, Journal of Islamabad Medical and Dental College, V2, P9
   Marques P, 2022, REV PAUL PEDIATR, V40, DOI 10.1590/1984-0462/2022/40/2020494
   Mittiku YM, 2022, FRONT GLOB WOMEN HLT, V3, DOI 10.3389/fgwh.2022.917643
   Mousa M, 2021, FRONT REPROD HEALTH, V3, DOI 10.3389/frph.2021.661360
   Mykolayivna NI, 2023, ANN MED SURG, V85, P3428, DOI 10.1097/MS9.0000000000000974
   Naz MSG, 2022, INT J ENDOCRINOL MET, V20, DOI 10.5812/ijem.120438
   Nobles J, 2022, P NATL ACAD SCI USA, V119, DOI 10.1073/pnas.2113762118
   Odongo E, 2023, BMC WOMENS HEALTH, V23, DOI 10.1186/s12905-023-02290-7
   Peña AS, 2018, ARCH DIS CHILD, V103, P235, DOI 10.1136/archdischild-2017-312968
   Rababa'h AM, 2022, HELIYON, V8, DOI 10.1016/j.heliyon.2022.e11010
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Sangaraju SL, 2022, CUREUS J MED SCIENCE, V14, DOI 10.7759/cureus.25076
   Saso S, 2011, BMJ-BRIT MED J, V343, DOI 10.1136/bmj.d3954
   Sembulingam K, 2016, Essential of Medical Physiology, V7
   Sharma S, 2016, BMC WOMENS HEALTH, V16, DOI 10.1186/s12905-016-0354-y
   Shufelt CL, 2017, SEMIN REPROD MED, V35, P256, DOI 10.1055/s-0037-1603581
   Sinha S, 2022, LIFE-BASEL, V12, DOI 10.3390/life12040564
   Soliman P, 2013, Comprehensive Gynecology: Neoplastic Diseases of the Uterus
   Taheri R, 2020, J NUTR METAB, V2020, DOI 10.1155/2020/5980685
   Tang YH, 2020, BMC WOMENS HEALTH, V20, DOI 10.1186/s12905-020-01085-4
   Tayebi N, 2018, J NATL MED ASSOC, V110, P440, DOI 10.1016/j.jnma.2017.10.007
   Taylor S, 2015, POL ARCH MED WEWN, V125, P452, DOI 10.20452/pamw.2888
   Toffol E, 2014, ARCH WOMEN MENT HLTH, V17, P127, DOI 10.1007/s00737-013-0399-y
   Ueno A, 2022, J OBSTET GYNAECOL RE, V48, P2005, DOI 10.1111/jog.15287
   Vale B, 2014, EINSTEIN-SAO PAULO, V12, P175, DOI 10.1590/S1679-45082014AO2942
   Vigil P, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.951186
   Wang YX, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2022.38513
   Wang YX, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.27928
   Whitaker L, 2016, BEST PRACT RES CL OB, V34, P54, DOI 10.1016/j.bpobgyn.2015.11.012
   Williams CE, 2012, HORM RES PAEDIAT, V78, P135, DOI 10.1159/000342822
   Wouk N, 2019, AM FAM PHYSICIAN, V99, P435
   Yu M, 2017, J AFFECT DISORDERS, V210, P43, DOI 10.1016/j.jad.2016.11.036
   Zeru AB, 2021, REPROD HEALTH, V18, DOI 10.1186/s12978-021-01156-1
NR 76
TC 20
Z9 20
U1 5
U2 20
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD NOV 20
PY 2023
VL 15
IS 11
AR e49146
DI 10.7759/cureus.49146
PG 9
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA Z3AB5
UT WOS:001110823400040
PM 38130524
OA gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Hansel, B
   Bonnefont-Rousselot, D
   Orsoni, A
   Bittar, R
   Giral, P
   Roussel, R
   Marre, M
   Mohammedi, K
   Bruckert, E
   Chapman, MJ
   Kontush, A
AF Hansel, Boris
   Bonnefont-Rousselot, Dominique
   Orsoni, Alexina
   Bittar, Randa
   Giral, Philippe
   Roussel, Ronan
   Marre, Michel
   Mohammedi, Kamel
   Bruckert, Eric
   Chapman, Martin John
   Kontush, Anatol
TI Lifestyle intervention enhances high-density Lipoprotein function among
   patients with metabolic syndrome only at normal low-density lipoprotein
   cholesterol plasma levels
SO JOURNAL OF CLINICAL LIPIDOLOGY
LA English
DT Article
DE Metabolic syndrome; High-density lipoprotein; Antioxidative activity;
   Oxidative stress; Lifestyle intervention
ID ELEVATED OXIDATIVE STRESS; TYPE-2 DIABETES-MELLITUS;
   CORONARY-HEART-DISEASE; APOLIPOPROTEIN-A-I; ANTIOXIDATIVE ACTIVITY;
   PARTICLE-SIZE; CARDIOVASCULAR-DISEASE; MULTICENTER EVALUATION;
   PRIMARY-PREVENTION; OBESE-PATIENTS
AB BACKGROUND: Metabolic syndrome (MetS) is associated with altered lipoprotein metabolism and impairment in the functionality of small, dense high-density lipoprotein (HDL) particles secondary to compositional alterations.
   OBJECTIVE: The objective of this study was to investigate the capacity of a lifestyle program to improve the composition and antioxidative function (AOX) of small dense HDL3c in MetS.
   METHODS: Patients with MetS (n = 33) not taking lipid-lowering drugs were recruited to follow a 12-week educational program to reduce caloric intake and to increase physical activity. HDL subfractions were preparatively isolated by isopycnic density-gradient ultracentrifugation. AOX of HDL3c was assessed as its capacity to inhibit low-density lipoprotein oxidation induced by an azoinitiator.
   RESULTS: AOX of HDL3c was significantly improved (mean reduction in the propagation rate of low-density lipoprotein oxidation by HDL3c, 6.8%, P =.03) and systemic oxidative stress, assessed as plasma levels of 8-isoprostanes, tended to decrease in normocholesterolemic MetS patients (low density lipoprotein cholesterol [LDL-C] < 130 mg/dL) but not in patients with elevated LDL-C levels and in the whole study population. In both the whole study population and the normocholesterolemic subgroup, lifestyle intervention resulted in a significant degree of normalization of HDL3c composition, (enrichment in apolipoprotein A-I and cholesteryl esters, depletion in triglycerides), which was more pronounced at LDL-C < 130 mg/dL.
   CONCLUSION: In patients with MetS, a lifestyle program improves AOX of small, dense HDL in subjects with normal LDL-C levels. Correction of HDL composition, involving partial normalization of apoA-I content and core lipid composition, 2 central features of the lipid hydroperoxide-inactivating capacity of HDL, may account for this effect. (C) 2016 National Lipid Association. All rights reserved.
C1 [Hansel, Boris; Roussel, Ronan; Marre, Michel; Mohammedi, Kamel] Hop Bichat Claude Bernard, Assistance Publ Hop Paris, DHU FIRE, Dept Endocrinol Diabetol & Nutr, Paris, France.
   [Hansel, Boris; Roussel, Ronan; Marre, Michel; Mohammedi, Kamel] Ctr Rech Cordeliers, INSERM, U1138, Paris, France.
   [Hansel, Boris; Roussel, Ronan; Marre, Michel] Univ Paris 07, Paris, France.
   [Bonnefont-Rousselot, Dominique; Bittar, Randa] Grp Hosp Pitie Salpetriere Charles Foix, AP HP, Serv Biochim Metab, Paris, France.
   [Bonnefont-Rousselot, Dominique; Orsoni, Alexina; Bittar, Randa; Chapman, Martin John; Kontush, Anatol] Univ Paris 06, Hop Pitie, INSERM UMRS ICAN 1166, Paris, France.
   [Bonnefont-Rousselot, Dominique] Univ Paris 05, Fac Pharm, Paris, France.
   [Giral, Philippe; Bruckert, Eric] Hop Pitie, AP HP, Serv Endocrinol Metab, Paris, France.
C3 Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP);
   Hopital Universitaire Bichat-Claude Bernard - APHP; Hopital
   Universitaire Saint-Louis - APHP; Sorbonne Universite; Universite Paris
   Cite; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite Paris Cite; Assistance Publique Hopitaux Paris
   (APHP); Hopital Universitaire Charles-Foix - APHP; Sorbonne Universite;
   Hopital Universitaire Pitie-Salpetriere - APHP; Assistance Publique
   Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Sorbonne Universite; Universite Paris Cite; Sorbonne Universite;
   Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Pitie-Salpetriere - APHP
RP Hansel, B (corresponding author), Hop Bichat Claude Bernard, Serv Endocrinol Metab, 46 Rue Henri Huchard, F-75018 Paris, France.
EM boris.hansel@aphp.fr
RI Mohammedi, Kamel/AAG-3129-2019; Rousselot, Bonnefont/U-7434-2019;
   chapman, john/Y-2742-2019; Greiver, Michelle/N-8764-2015; Kontush,
   Anatol/J-2198-2016; ORSONI, Alexina/C-6740-2009
OI ORSONI, Alexina/0000-0003-4250-6280; Mohammedi,
   Kamel/0000-0001-6139-1197; Bonnefont-Rousselot,
   Dominique/0000-0003-4689-9202; Kontush, Anatol/0000-0002-9008-7335
FU National Institute of Health and Medical Research; University of Pierre
   and Mary Curie (UPMC); Fondation de France; Agence Nationale de la
   Recherche (ANR); Fondation pour la Recherche Medicale
FX This study was supported by the National Institute of Health and Medical
   Research, University of Pierre and Mary Curie (UPMC), the Fondation de
   France, the Agence Nationale de la Recherche (ANR), and the Fondation
   pour la Recherche Medicale. We are indebted to all subjects and nursing
   staff involved in the study.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   ALLAIN CC, 1974, CLIN CHEM, V20, P470
   Bayer P, 2005, ANN BIOL CLIN-PARIS, V63, P27
   Bays HE, 2013, J CLIN LIPIDOL, V7, P304, DOI 10.1016/j.jacl.2013.04.001
   BLANCHE PJ, 1981, BIOCHIM BIOPHYS ACTA, V665, P408, DOI 10.1016/0005-2760(81)90253-8
   Carmena R, 2004, CIRCULATION, V109, P2, DOI 10.1161/01.CIR.0000131511.50734.44
   Casella A, 2011, AM J CARDIOL, V107, P1168, DOI 10.1016/j.amjcard.2010.12.014
   Chapman MJ, 2011, EUR HEART J, V32, P1345, DOI 10.1093/eurheartj/ehr112
   Chapman MJ, 2010, EUR HEART J, V31, P149, DOI 10.1093/eurheartj/ehp399
   CHAPMAN MJ, 1981, J LIPID RES, V22, P339
   Curtiss LK, 2000, BIOCHEMISTRY-US, V39, P5712, DOI 10.1021/bi992902m
   Egloff M, 1999, ANN BIOL CLIN-PARIS, V57, P561
   Estruch R, 2013, NEW ENGL J MED, V368, P1279, DOI 10.1056/NEJMoa1200303
   FOSSATI P, 1982, CLIN CHEM, V28, P2077
   FRICK MH, 1987, NEW ENGL J MED, V317, P1237, DOI 10.1056/NEJM198711123172001
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Hansel Boris, 2006, Curr Atheroscler Rep, V8, P501, DOI 10.1007/s11883-006-0026-8
   Hourcade-Potelleret F, 2015, HEART, V101, P847, DOI 10.1136/heartjnl-2014-306691
   Hulthe J, 2000, ARTERIOSCL THROM VAS, V20, P2140, DOI 10.1161/01.ATV.20.9.2140
   Iborra RT, 2008, SCAND J MED SCI SPOR, V18, P742, DOI 10.1111/j.1600-0838.2007.00748.x
   Kontush A, 2005, ATHEROSCLEROSIS, V182, P277, DOI 10.1016/j.atherosclerosis.2005.03.001
   Kontush A, 2003, ARTERIOSCL THROM VAS, V23, P1881, DOI 10.1161/01.ATV.0000091338.93223.E8
   KONTUSH A, 1995, BBA-LIPID LIPID MET, V1258, P177, DOI 10.1016/0005-2760(95)00115-S
   Mendez JI, 2005, ARTERIOSCL THROM VAS, V25, P887, DOI 10.1161/01.ATV.0000164043.24549.50
   Nobécourt E, 2005, DIABETOLOGIA, V48, P529, DOI 10.1007/s00125-004-1655-5
   Pascot A, 2001, J LIPID RES, V42, P2007
   Rector RS, 2007, AM J PHYSIOL-ENDOC M, V293, pE500, DOI 10.1152/ajpendo.00116.2007
   Roberts CK, 2006, J APPL PHYSIOL, V101, P1727, DOI 10.1152/japplphysiol.00345.2006
   Rubins HB, 1999, NEW ENGL J MED, V341, P410, DOI 10.1056/NEJM199908053410604
   RUMSEY SC, 1994, J LIPID RES, V35, P1592
   Schwingshackl L, 2013, J ACAD NUTR DIET, V113, P1640, DOI 10.1016/j.jand.2013.07.010
   SPARKS DL, 1995, J BIOL CHEM, V270, P26910, DOI 10.1074/jbc.270.45.26910
   Vekic J, 2009, ATHEROSCLEROSIS, V207, P496, DOI 10.1016/j.atherosclerosis.2009.06.035
   Wang YA, 2011, DIABETES CARE, V34, P2576, DOI 10.2337/dc11-0685
   Wing R, 2013, NEW ENGL J MED, V369, P145, DOI 10.1056/NEJMoa1212914
NR 35
TC 10
Z9 14
U1 0
U2 16
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1933-2874
EI 1876-4789
J9 J CLIN LIPIDOL
JI J. Clin. Lipidol.
PD OCT
PY 2016
VL 10
IS 5
BP 1172
EP 1181
DI 10.1016/j.jacl.2016.05.008
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DZ5LN
UT WOS:000385903700015
PM 27678434
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Institoris, A
   Lenti, L
   Domoki, F
   Wappler, E
   Gáspár, T
   Katakam, PV
   Bari, F
   Busija, DW
AF Institoris, Adam
   Lenti, Laura
   Domoki, Ferenc
   Wappler, Edina
   Gaspar, Tamas
   Katakam, Prasad V.
   Bari, Ferenc
   Busija, David W.
TI Cerebral Microcirculatory Responses of Insulin-Resistant Rats are
   Preserved to Physiological and Pharmacological Stimuli
SO MICROCIRCULATION
LA English
DT Article
DE Zucker obese; cortical spreading depression; N-methyl-d-aspartate;
   bicuculline; hypercapnia
ID METHYL-D-ASPARTATE; CORTICAL SPREADING DEPRESSION; NITRIC-OXIDE
   SYNTHASE; ZUCKER OBESE RATS; PIAL ARTERIOLAR DILATION; METABOLIC
   SYNDROME; BLOOD-FLOW; K-ATP; INDUCED VASODILATION; EPILEPTIFORM EVENTS
AB Objective Previously, we have shown that IR impairs the vascular reactivity of the major cerebral arteries of ZO rats prior to the occurrence of Type-II diabetes mellitus. However, the functional state of the microcirculation in the cerebral cortex is still being explored.
   Methods We tested the local CoBF responses of 11-13-week-old ZO (n = 31) and control ZL (n = 32) rats to several stimuli measured by LDF using a closed cranial window setup.
   Results The topical application of 1-100 mu m bradykinin elicited the same degree of CoBF elevation in both ZL and ZO groups. There was no significant difference in the incidence, latency, and amplitude of the NMDA-induced CSD-related hyperemia between the ZO and ZL groups. Hypercapnic CoBF response to 5% carbon-dioxide ventilation did not significantly change in the ZO compared with the ZL. Topical bicuculline-induced cortical seizure was accompanied by the same increase of CoBF in both the ZO and ZL at all bicuculline doses.
   Conclusions CoBF responses of the microcirculation are preserved in the early period of the metabolic syndrome, which creates an opportunity for intervention to prevent and restore the function of the major cerebral vascular beds.
C1 [Institoris, Adam] Univ Szeged, Dept Physiol, Fac Med, Sch Med, H-6720 Szeged, Hungary.
   [Institoris, Adam; Lenti, Laura; Katakam, Prasad V.; Busija, David W.] Wake Forest Univ Hlth Sci, Dept Physiol & Pharmacol, Winston Salem, NC USA.
   [Wappler, Edina; Katakam, Prasad V.; Busija, David W.] Tulane Univ, Sch Med, Dept Pharmacol, New Orleans, LA 70112 USA.
   [Bari, Ferenc] Univ Szeged, Dept Med Informat & Med Phys, Sch Med, H-6720 Szeged, Hungary.
C3 Szeged University; Wake Forest University; Wake Forest University School
   of Medicine; Tulane University; Szeged University
RP Institoris, A (corresponding author), Univ Szeged, Dept Physiol, Fac Med, Sch Med, Dom Ter 10, H-6720 Szeged, Hungary.
EM instiadam@gmail.com
RI K, P/AAL-6310-2021; Domoki, Ferenc/K-5336-2012
OI Wappler-Guzzetta, Edina/0000-0002-2195-5960; Katakam,
   Prasad/0000-0002-4708-9140
FU National Heart, Lung, and Blood Institute [HL-030260, HL-065380,
   HL-077731, HL-093554]; Hungarian Scientific Research Fund [OTKA K81266,
   TAMOP-4.2.1./B-09/1/konv-2010-0005]; Janos Bolyai Research Scholarship
   of the Hungarian Academy of Sciences
FX We thank Nancy Busija for editing the manuscript. This work was
   supported by National Heart, Lung, and Blood Institute Grants HL-030260,
   HL-065380, HL-077731, and HL-093554, Hungarian Scientific Research Fund
   Grant OTKA K81266, and TAMOP-4.2.1./B-09/1/konv-2010-0005. Ferenc Domoki
   was supported by the Janos Bolyai Research Scholarship of the Hungarian
   Academy of Sciences.
CR Attwell D, 2010, NATURE, V468, P232, DOI 10.1038/nature09613
   Ayata C, 2006, AM J PHYSIOL-HEART C, V290, pH1837, DOI 10.1152/ajpheart.01102.2005
   Bari F, 1998, BRAIN RES, V780, P237, DOI 10.1016/S0006-8993(97)01196-7
   Bari F, 1996, STROKE, V27, P1634, DOI 10.1161/01.STR.27.9.1634
   Boison D, 2005, NEUROSCIENTIST, V11, P25, DOI 10.1177/1073858404269112
   Brian JE, 2001, AM J PHYSIOL-HEART C, V280, pH2023, DOI 10.1152/ajpheart.2001.280.5.H2023
   Busija DW, 2007, BRAIN RES REV, V56, P89, DOI 10.1016/j.brainresrev.2007.05.011
   Busija David W, 2004, Curr Opin Investig Drugs, V5, P929
   BUSIJA DW, 1981, AM J PHYSIOL, V241, pH228, DOI 10.1152/ajpheart.1981.241.2.H228
   Church T, 2011, PROG CARDIOVASC DIS, V53, P412, DOI 10.1016/j.pcad.2011.03.013
   Dirnagl U, 2010, J CEREBR BLOOD F MET, V30, P1, DOI [10.1038/jcbfm.2009.252, 10.1038/jcbfm.2010.191]
   Domoki F, 2002, AM J PHYSIOL-HEART C, V282, pH1404, DOI 10.1152/ajpheart.00523.2001
   Dreier JP, 2011, NAT MED, V17, P439, DOI 10.1038/nm.2333
   Erdös B, 2006, AM J PHYSIOL-HEART C, V290, pH1264, DOI 10.1152/ajpheart.00804.2005
   Erdös B, 2004, AM J PHYSIOL-REG I, V287, pR1456, DOI 10.1152/ajpregu.00279.2004
   Erdös B, 2004, DIABETES, V53, P1352, DOI 10.2337/diabetes.53.5.1352
   Erdös B, 2004, STROKE, V35, P964, DOI 10.1161/01.STR.0000119753.05670.F1
   Erdös B, 2002, AM J PHYSIOL-HEART C, V283, pH2472, DOI 10.1152/ajpheart.00516.2002
   Erdös B, 2002, AM J PHYSIOL-HEART C, V282, pH2060, DOI 10.1152/ajpheart.01124.2001
   Estevez AY, 1997, BRAIN RES, V758, P1, DOI 10.1016/S0006-8993(97)00154-6
   FABRICIUS M, 1995, AM J PHYSIOL-HEART C, V269, pH23, DOI 10.1152/ajpheart.1995.269.1.H23
   FARACI FM, 1995, AM J PHYSIOL-HEART C, V269, pH1522, DOI 10.1152/ajpheart.1995.269.5.H1522
   FARACI FM, 1993, CIRC RES, V72, P476, DOI 10.1161/01.RES.72.2.476
   Farkas E, 2008, J CEREBR BLOOD F MET, V28, P251, DOI 10.1038/sj.jcbfm.9600569
   Filosa JA, 2006, NAT NEUROSCI, V9, P1397, DOI 10.1038/nn1779
   Fulesdi Bela, 1998, Orvosi Hetilap, V139, P1789
   Haratz S, 2011, CURR OPIN NEUROL, V24, P81, DOI 10.1097/WCO.0b013e3283418fed
   Heinert G, 1999, ACTA PHYSIOL SCAND, V166, P183
   Hodnett BL, 2008, MICROCIRCULATION, V15, P485, DOI 10.1080/10739680801942240
   Horiuchi T, 2002, STROKE, V33, P844, DOI 10.1161/hs0302.104112
   IADECOLA C, 1994, AM J PHYSIOL, V267, pR228, DOI 10.1152/ajpregu.1994.267.1.R228
   Iadecola C, 1996, AM J PHYSIOL-REG I, V271, pR990, DOI 10.1152/ajpregu.1996.271.4.R990
   Institoris A, 2011, AM J PHYSIOL-HEART C, V300, pH2080, DOI 10.1152/ajpheart.01169.2010
   Katakam PVG, 2005, AM J PHYSIOL-HEART C, V288, pH854, DOI 10.1152/ajpheart.00715.2004
   Katakam PVG, 1998, AM J PHYSIOL-REG I, V275, pR788, DOI 10.1152/ajpregu.1998.275.3.R788
   Knot HJ, 1996, J PHYSIOL-LONDON, V492, P419, DOI 10.1113/jphysiol.1996.sp021318
   Lenti L, 2009, MICROCIRCULATION, V16, P629, DOI 10.1080/10739680903131510
   Lindauer U, 2003, J CEREBR BLOOD F MET, V23, P1227, DOI 10.1097/01.WCB.0000088764.02615.B7
   Liu HT, 2009, J PHYSIOL-LONDON, V587, P2197, DOI 10.1113/jphysiol.2008.165084
   Ma HT, 2009, J NEUROPHYSIOL, V101, P2550, DOI 10.1152/jn.90694.2008
   Ma HT, 2004, J NEUROPHYSIOL, V91, P934, DOI 10.1152/jn.00274.2003
   Magistretti PJ, 1999, NEWS PHYSIOL SCI, V14, P177, DOI 10.1152/physiologyonline.1999.14.5.177
   MOSKOWITZ MA, 1990, NEUROL CLIN, V8, P801, DOI 10.1016/S0733-8619(18)30318-9
   Najarian RM, 2006, ARCH INTERN MED, V166, P106, DOI 10.1001/archinte.166.1.106
   Niwa K, 2001, CIRC RES, V88, P600, DOI 10.1161/01.RES.88.6.600
   Osmond JM, 2009, HYPERTENSION, V53, P381, DOI 10.1161/HYPERTENSIONAHA.108.124149
   Philip S, 2004, BRAIN RES BULL, V63, P127, DOI 10.1016/j.brainresbull.2004.01.007
   Phillips SA, 2005, AM J PHYSIOL-REG I, V288, pR522, DOI 10.1152/ajpregu.00655.2004
   Phillis JW, 2004, NEUROSCI LETT, V365, P6, DOI 10.1016/j.neulet.2004.03.094
   Reuter U, 1998, AM J PHYSIOL-HEART C, V274, pH1979, DOI 10.1152/ajpheart.1998.274.6.H1979
   ROSENBLUM WI, 1987, CIRC RES, V61, P601, DOI 10.1161/01.RES.61.4.601
   Shimizu K, 2002, BRAIN RES, V928, P40, DOI 10.1016/S0006-8993(01)03352-2
   Sobey CG, 1997, STROKE, V28, P2290, DOI 10.1161/01.STR.28.11.2290
   Song DZ, 2008, EUR J PHARMACOL, V591, P177, DOI 10.1016/j.ejphar.2008.06.036
   Stepp DW, 2004, AM J PHYSIOL-HEART C, V286, pH964, DOI 10.1152/ajpheart.00836.2003
   Tanne D, 2004, STROKE, V35, P2351, DOI 10.1161/01.STR.0000140738.94047.55
   Vermeer SE, 2006, STROKE, V37, P1413, DOI 10.1161/01.STR.0000221766.73692.0b
   WEI EP, 1980, AM J PHYSIOL, V238, pH697, DOI 10.1152/ajpheart.1980.238.5.H697
   Xiang LS, 2008, AM J PHYSIOL-HEART C, V294, pH1658, DOI 10.1152/ajpheart.01206.2007
   YANG ST, 1991, STROKE, V22, P1177, DOI 10.1161/01.STR.22.9.1177
   Yang ST, 1998, NEUROREPORT, V9, P415, DOI 10.1097/00001756-199802160-00011
NR 61
TC 8
Z9 9
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1073-9688
EI 1549-8719
J9 MICROCIRCULATION
JI Microcirculation
PD NOV
PY 2012
VL 19
IS 8
BP 749
EP 756
DI 10.1111/j.1549-8719.2012.00213.x
PG 8
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 041CI
UT WOS:000311373400009
PM 22845548
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Lucini, D
   Zanuso, S
   Blair, S
   Pagani, M
AF Lucini, Daniela
   Zanuso, Silvano
   Blair, Steven
   Pagani, Massimo
TI A simple healthy lifestyle index as a proxy of wellness: a proof of
   concept
SO ACTA DIABETOLOGICA
LA English
DT Article
DE Clinical prevention; Cardiovascular health; Diet; Stress; Exercise
ID PHYSICAL-ACTIVITY; CARDIOVASCULAR-DISEASE; SCIENTIFIC STATEMENT;
   METABOLIC SYNDROME; RISK-FACTORS; PUBLIC-HEALTH; PRIMARY-CARE; STRESS;
   PREVENTION; IMPACT
AB The evidence supporting the importance of a healthy lifestyle (active life, healthy diet, not smoking, and low stress) as a part of programs for primary and secondary prevention of cardiometabolic diseases is strong, compelling, and continuously growing. In this study, we test whether a simple web-based healthy lifestyle index, using self-reports, is related to indices of cardiovascular health and metabolic syndrome and could be employed in large wellness programs intended to promote healthy lifestyle. We studied 411 workers in an Italian multinational factory who were enrolled in a voluntary program consisting of a health checkup and an online questionnaire on lifestyle. These domains were combined into a single simple index. Participants were subdivided into three healthy lifestyle index (HI) groups (red, yellow, and green) ranging from poor to good HI quality (HI from red to green: 41.8 +/- A 14.6; 75.7 +/- A 8.5; 93.8 +/- A 2.2; p < 0.05). The groups differed in indicators of cardiovascular and metabolic health (waist circumference females: 82.1 +/- A 9.56, 78.9 +/- A 9.3, 72.7 +/- A 6.6; males: 95.2 +/- A 11.7, 90.0 +/- A 9.5, 85.7 +/- A 6.1 cm; group difference p < 0.05). Moreover, they differed significantly in the likelihood of having more components of the metabolic syndrome and, conversely, fewer components of the ideal cardiovascular health profile (with red having the worst profile). The red group was also characterized by the highest absenteeism. We report for the first time that a web-based self-reported poor health behavior was significantly associated with clinical and laboratory (partial correlation between HI and high-density cholesterol 0.192; body mass index -0.288; systolic blood pressure -0.130; all p < 0.05) results indicating a negative cardiometabolic profile.
C1 [Lucini, Daniela; Pagani, Massimo] Univ Milan, Ctr Ric Terapia Neurovegetat & Med Esercizio, Milan, Italy.
   [Lucini, Daniela] Humanitas Clin & Res Ctr, UO Med Esercizio & Patol Funz, I-20089 Milan, Italy.
   [Zanuso, Silvano] Univ Greenwich, Chatham, Kent, England.
   [Zanuso, Silvano] Technogym Sci Dept, Cesena, Italy.
   [Blair, Steven] Univ S Carolina, Dept Exercise Sci & Epidemiol & Biostat, Columbia, SC 29208 USA.
C3 University of Milan; University of Greenwich; University of South
   Carolina System; University of South Carolina Columbia
RP Lucini, D (corresponding author), Humanitas Clin & Res Ctr, UO Med Esercizio & Patol Funz, Via Alessandro Manzoni 56, I-20089 Milan, Italy.
EM daniela.lucini@unimi.it
RI Blair, Steven/AFU-2008-2022; Lucini, Daniela/ABD-7517-2021
OI Lucini, Daniela/0000-0003-4845-8988
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   [Anonymous], 2008, Physical Activity Guidelines for Americans
   [Anonymous], EUR J PREV CARDIOL
   [Anonymous], J SPORTS MED PHYS FI
   [Anonymous], HEART
   Artinian NT, 2010, CIRCULATION, V122, P406, DOI 10.1161/CIR.0b013e3181e8edf1
   Babio N, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0058354
   Barlow SE, 2007, PEDIATRICS, V120, pS164, DOI 10.1542/peds.2007-2329C
   Carnethon M, 2009, CIRCULATION, V120, P1725, DOI 10.1161/CIRCULATIONAHA.109.192653
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   D'Agostino RB, 2008, CIRCULATION, V117, P743, DOI 10.1161/CIRCULATIONAHA.107.699579
   Ford ES, 2012, CIRCULATION, V125, P987, DOI 10.1161/CIRCULATIONAHA.111.049122
   Ford ES, 2005, OBES RES, V13, P608, DOI 10.1038/oby.2005.65
   Franks PW, 2010, NEW ENGL J MED, V362, P485, DOI 10.1056/NEJMoa0904130
   Go AS, 2014, CIRCULATION, V129, pE28, DOI 10.1161/01.cir.0000441139.02102.80
   Hancox RJ, 2004, LANCET, V364, P257, DOI 10.1016/S0140-6736(04)16675-0
   Haskell WL, 2007, MED SCI SPORT EXER, V39, P1423, DOI [10.1249/mss.0b013e3180616b27, 10.1161/CIRCULATIONAHA.107.185649]
   Hjemdahl P, 2002, CIRCULATION, V106, P2634, DOI 10.1161/01.CIR.0000041502.43564.79
   Jha P, 2013, NEW ENGL J MED, V368, P341, DOI 10.1056/NEJMsa1211128
   Jones DW, 2009, CIRCULATION, V119, P340, DOI 10.1161/CIRCULATIONAHA.108.191328
   Kaspin LC, 2013, POPUL HEALTH MANAG, V16, P14, DOI 10.1089/pop.2012.0006
   Liu K, 2012, CIRCULATION, V125, P996, DOI 10.1161/CIRCULATIONAHA.111.060681
   Lloyd-Jones DM, 2010, CIRCULATION, V121, P586, DOI 10.1161/CIRCULATIONAHA.109.192703
   Lopez-Carmona D, 2012, EUR J PREV CARDIOL, V19, P1074, DOI 10.1177/1741826711418166
   Lucini D, 2006, J HYPERTENS, V24, P361, DOI 10.1097/01.hjh.0000202817.02836.9c
   Lucini D, 2005, HYPERTENSION, V46, P1201, DOI 10.1161/01.HYP.0000185147.32385.4b
   Lucini D, 2002, HYPERTENSION, V39, P184, DOI 10.1161/hy0102.100784
   Lucini D, 2007, HYPERTENSION, V49, P291, DOI 10.1161/01.HYP.0000255034.42285.58
   Lucini D, 2011, J MED INTERNET RES, V13, DOI 10.2196/jmir.1798
   Lucini D, 2011, EUR J INTERN MED, V22, P363, DOI 10.1016/j.ejim.2011.02.022
   Lucini D, 2009, J HYPERTENS, V27, P2421, DOI 10.1097/HJH.0b013e3283312c24
   Marcus BH, 2009, BRIT J SPORT MED, V43, P102, DOI 10.1136/bjsm.2008.053744
   Mitchell JA, 2010, AM HEART J, V160, P102, DOI 10.1016/j.ahj.2010.05.001
   Niessen MAJ, 2012, J OCCUP ENVIRON MED, V54, P404, DOI 10.1097/JOM.0b013e31824d2e43
   Olshansky SJ, 2005, NEW ENGL J MED, V352, P1138, DOI 10.1056/NEJMsr043743
   ORNISH D, 1990, LANCET, V336, P129, DOI 10.1016/0140-6736(90)91656-U
   Pearson TA, 2013, CIRCULATION, V127, P1730, DOI 10.1161/CIR.0b013e31828f8a94
   Perk J, 2012, INT J BEHAV MED, V19, P403, DOI 10.1007/s12529-012-9242-5
   Rozanski A, 2005, J AM COLL CARDIOL, V45, P637, DOI 10.1016/j.jacc.2004.12.005
   Strath SJ, 2013, CIRCULATION, V128, P2259, DOI 10.1161/01.cir.0000435708.67487.da
   Weintraub WS, 2011, CIRCULATION, V124, P967, DOI 10.1161/CIR.0b013e3182285a81
   Yang QH, 2012, JAMA-J AM MED ASSOC, V307, P1273, DOI 10.1001/jama.2012.339
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
NR 43
TC 21
Z9 22
U1 0
U2 18
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD FEB
PY 2015
VL 52
IS 1
BP 81
EP 89
DI 10.1007/s00592-014-0605-z
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CA9EQ
UT WOS:000349224100010
PM 24915785
DA 2025-06-11
ER

PT J
AU Scheinberg, AR
   Martin, P
   Turkeltaub, JA
AF Scheinberg, Andrew R.
   Martin, Paul
   Turkeltaub, Joshua A.
TI Long-Term Care of the Liver Transplant Recipient
SO CLINICS IN LIVER DISEASE
LA English
DT Article
DE Liver transplant; Complications; Long-term care; Metabolic syndrome;
   Survivorship
ID RISK-FACTORS; HYPERTENSION; MANAGEMENT; OBESITY; CANCER; OUTCOMES;
   DISEASE
AB Decades of advances in surgical techniques and immunosuppression regimens afford the liver transplant recipient increased longevity. Many of the metabolic derangements managed in the liver transplant recipient will require pharmacologic intervention; however, the importance of minimizing immunosuppression, if feasible, combined with a healthy lifestyle cannot be over emphasized. One of the goals of liver transplantation in addition to prolonging survival is to improve the recipient's quality of life (QoL). Assessments of QoL, mood, and screening for mental health issues should be routinely performed. The concept of survivorship, initially adopted in the world of oncology, highlights a more holistic approach to the liver transplant recipient with an emphasis on psychological, social, and spiritual well-being along with the medical management.42 In addition to ongoing efforts to further improve graft survival and improve the longevity of liver transplant recipients, further research exploring transplant survivorship domains will also ensure improved outcomes and overall success.42
C1 [Scheinberg, Andrew R.; Turkeltaub, Joshua A.] Univ Miami, Miller Sch Med, Div Digest Hlth & Liver Dis, 1120 Northwest 14th St, Miami, FL 33136 USA.
   [Martin, Paul] Cedars Sinai Med Ctr, Comprehens Transplant Ctr, Karsh Div Gastroenterol & Hepatol, Clin Hepatol Educ & Res, Los Angeles, CA USA.
C3 University of Miami; Cedars Sinai Medical Center
RP Scheinberg, AR (corresponding author), Univ Miami, Miller Sch Med, Div Digest Hlth & Liver Dis, 1120 Northwest 14th St, Miami, FL 33136 USA.
EM ascheinberg@med.miami.edu
CR Acuna SA, 2017, AM J TRANSPLANT, V17, P103, DOI 10.1111/ajt.13978
   Agostini C, 2023, J CLIN MED, V12, DOI 10.3390/jcm12196173
   Azhie A, 2021, LIVER TRANSPLANT, V27, P1468, DOI 10.1002/lt.26219
   Becchetti C, 2020, WORLD J GASTROENTERO, V26, P2138, DOI 10.3748/wjg.v26.i18.2138
   Brandman D, 2021, CLIN LIVER DIS, V25, P1, DOI 10.1016/j.cld.2020.08.001
   Canzanello VJ, 1998, LIVER TRANSPLANT SUR, V4, P328, DOI 10.1002/lt.500040404
   Charlton M, 2017, TRANSPLANTATION, V101, P2873, DOI 10.1097/TP.0000000000001913
   Curry SJ, 2018, OBSTET GYNECOL SURV, V73, P689, DOI [10.1001/jama.2018.10897, 10.1097/01.ogx.0000549540.69362.81]
   Desai S, 2010, LIVER INT, V30, P948, DOI 10.1111/j.1478-3231.2010.02274.x
   Euvrard S, 2004, DERMATOL SURG, V30, P628, DOI 10.1111/j.1524-4725.2004.30148.x
   Fairfield C, 2018, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007606.pub4
   Rodríguez-Aguilar EF, 2021, TRANSPL P, V53, P2346, DOI 10.1016/j.transproceed.2021.07.049
   Fuochi E, 2023, WORLD J HEPATOL, V15, P321, DOI 10.4254/wjh.v15.i3.321
   Galioto A, 2005, TRANSPLANT P, V37, P1245, DOI 10.1016/j.transproceed.2005.01.066
   Heimbach JK, 2013, AM J TRANSPLANT, V13, P363, DOI 10.1111/j.1600-6143.2012.04318.x
   Izzy M, 2022, AM J TRANSPLANT, V22, P2740, DOI 10.1111/ajt.17049
   Kumar SE, 2023, J CLIN EXP HEPATOL, V13, P1130, DOI 10.1016/j.jceh.2023.05.003
   Lai JC, 2020, LIVER TRANSPLANT, V26, P1030, DOI 10.1002/lt.25792
   Lee Chang Hwa, 2007, Electrolyte Blood Press, V5, P126, DOI 10.5049/EBP.2007.5.2.126
   Lim WH, 2021, TRANSPL INT, V34, P1032, DOI 10.1111/tri.13863
   Lucey MR, 2013, LIVER TRANSPLANT, V19, P3, DOI 10.1002/lt.23566
   Mehta N, 2017, JAMA ONCOL, V3, P493, DOI 10.1001/jamaoncol.2016.5116
   Minjares RO, 2022, CLIN LIVER DIS, V26, P323, DOI 10.1016/j.cld.2022.01.006
   Mukthinuthalapati PK, 2016, WORLD J HEPATOL, V8, P533, DOI 10.4254/wjh.v8.i12.533
   Neuberger J, 2022, J CLIN EXP HEPATOL, V12, P1547, DOI 10.1016/j.jceh.2022.03.012
   Nishihori T, 2008, CLIN COLORECTAL CANC, V7, P260, DOI 10.3816/CCC.2008.n.033
   Odenwald MA, 2023, CLIN TRANSPLANT, V37, DOI 10.1111/ctr.15085
   Organ Procurement and Transplantation Network (OPTN) and Scientific Registry of Transplant Recipients (SRTR), 2023, OPTN/SRTR 2021 Annual Data Report
   Pais R, 2016, J HEPATOL, V65, P1245, DOI 10.1016/j.jhep.2016.07.033
   Pearlman M, 2017, OBSTET GYNECOL, V130, pE1, DOI 10.1097/AOG.0000000000002158
   Peláez-Jaramillo MJ, 2018, DIABETES THER, V9, P521, DOI 10.1007/s13300-018-0374-8
   Richardson B, 2022, HEPATOL COMMUN, V6, P1250, DOI 10.1002/hep4.1876
   Russo MW, 2024, LIVER TRANSPLANT, V30, P647, DOI 10.1097/LVT.0000000000000341
   Samson SL, 2023, ENDOCR PRACT, V29, P305, DOI 10.1016/j.eprac.2023.02.001
   Sarkar M, 2018, AM J TRANSPLANT, V18, P1068, DOI 10.1111/ajt.14697
   Schachter M, 2005, FUND CLIN PHARMACOL, V19, P117, DOI 10.1111/j.1472-8206.2004.00299.x
   Syed T, 2021, LIVER TRANSPLANT, V27, P1326, DOI 10.1002/lt.26069
   Textor SC, 2000, LIVER TRANSPLANT, V6, P521, DOI 10.1053/jlts.2000.9737
   Tsamalaidze L, 2018, OBES SURG, V28, P444, DOI 10.1007/s11695-017-2847-7
   Unger T, 2020, J HYPERTENS, V38, P982, DOI [10.1097/HJH.0000000000002453, 10.1161/HYPERTENSIONAHA.120.15026]
   Warden Bruce A, 2020, JACC Case Rep, V2, P396, DOI 10.1016/j.jaccas.2019.09.026
   Zamora-Valdes D, 2018, HEPATOLOGY, V68, P485, DOI 10.1002/hep.29848
NR 42
TC 0
Z9 0
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1089-3261
EI 1557-8224
J9 CLIN LIVER DIS
JI Clin. Liver Dis.
PD MAY
PY 2025
VL 29
IS 2
BP 303
EP 312
DI 10.1016/j.cld.2024.12.007
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 2ES2E
UT WOS:001480881300001
PM 40287273
DA 2025-06-11
ER

PT J
AU Moniruzzaman, M
   Reid, LA
   Jones, KK
   Zenk, SN
   Vega, GL
   Grundy, SM
   Sims, M
   Powell-Wiley, TM
   Tamura, K
AF Moniruzzaman, Mohammad
   Reid, Lauren A.
   Jones, Kelly K.
   Zenk, Shannon N.
   Vega, Gloria L.
   Grundy, Scott M.
   Sims, Mario
   Powell-Wiley, Tiffany M.
   Tamura, Kosuke
TI Multilevel Mediators on the Associations of Neighborhood Social
   Environmental Factors and Severity of Metabolic Syndrome: The Jackson
   Heart Study
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE C-reactive protein; mediation analysis; metabolic syndrome;
   neighborhood; physical activity
ID C-REACTIVE PROTEIN; AFRICAN-AMERICANS; PHYSICAL-ACTIVITY; PSYCHOSOCIAL
   STRESSORS; CARDIOVASCULAR HEALTH; RISK; DISPARITIES; COMMUNITIES;
   MANAGEMENT; SEX
AB Background Neighborhood characteristics serve as risk factors for metabolic syndrome (MetS). However, the intermediary factors linking this relationship remain understudied. Thus, we investigated the sex-specific mediating role of C-reactive protein, physical activity (PA), and perceived stress in the associations of perceived neighborhood social environment (PNSE) with MetS severity among Black adults.Methods and Results This cross-sectional study included 3185 adults (64% women) from exam 1 (2000-2004) of the Jackson Heart Study. MetS severity Z scores were calculated based on the Adult Treatment Panel III criteria formula. PNSE included neighborhood violence, problems, and social cohesion. Men and women were analyzed separately. A bootstrap resampling technique with 95% bias-corrected CI (95% BC CI) was used to evaluate whether C-reactive protein, PA, and perceived stress mediated the association between each PNSE and MetS severity, adjusting for covariates. All PNSE factors were directly related to MetS severity in women but not in men. In women, neighborhood problems were indirectly associated with MetS severity mediated through PA (beta=0.02 [95% BC CI, 0.00-0.05]). In men, neighborhood violence, problems, and social cohesion were indirectly associated with MetS severity mediated through PA (beta=0.05 [95% BC CI, 0.01-0.10]; beta=0.03 [95% BC CI, 0.00-0.06]; and beta=-0.04 [95% BC CI, -0.09 to -0.01], respectively). Neither C-reactive protein nor perceived stress mediated such associations in either women or men.Conclusions All PNSEs (violence, problems, and social cohesion) were directly related to MetS severity in women only. PA mediated the relationship between each PNSE and MetS in a sex-specific manner. Efforts focusing on local conditions are needed to better understand why such disparities exist for at-risk minoritized groups.
C1 [Moniruzzaman, Mohammad; Tamura, Kosuke] Natl Inst Minor Hlth & Hlth Dispar, Populat & Community Hlth Sci Branch, Div Intramural Res, Sociospatial Determinants Hlth SSDH Lab,NIH, Bldg 3,3 Ctr Dr, Bethesda, MD 20892 USA.
   [Reid, Lauren A.] South Coll, Sch Phys Assistant Studies, Atlanta, GA USA.
   [Reid, Lauren A.; Jones, Kelly K.; Zenk, Shannon N.] Natl Inst Minor Hlth & Hlth Dispar, Neighborhoods & Hlth Lab, Populat & Community Hlth Sci Branch, Div Intramural Res,NIH, Bethesda, MD USA.
   [Zenk, Shannon N.] Natl Inst Nursing Res, NIH, Bethesda, MD USA.
   [Vega, Gloria L.; Grundy, Scott M.] Univ Texas Southwestern Med Ctr Dallas, Ctr Human Nutr, Dallas, TX USA.
   [Sims, Mario] Univ Calif Riverside, Sch Med, Dept Social Med Populat & Publ Hlth, Riverside, CA USA.
   [Powell-Wiley, Tiffany M.] NHLBI, Social Determinants Obes & Cardiovasc Risk Lab, Cardiovasc Branch, Div Intramural Res, Bethesda, MD USA.
   [Powell-Wiley, Tiffany M.] Natl Inst Minor Hlth & Hlth Dispar, Div Intramural Res, NIH, Bethesda, MD USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Minority Health & Health Disparities (NIMHD); Division of Intramural
   Research (DIR); National Institutes of Health (NIH) - USA; NIH National
   Institute on Minority Health & Health Disparities (NIMHD); Division of
   Intramural Research (DIR); National Institutes of Health (NIH) - USA;
   NIH National Institute of Nursing Research (NINR); University of Texas
   System; University of Texas Southwestern Medical Center Dallas;
   University of California System; University of California Riverside;
   National Institutes of Health (NIH) - USA; NIH National Heart Lung &
   Blood Institute (NHLBI); National Institutes of Health (NIH) - USA;
   Division of Intramural Research (DIR); NIH National Institute on
   Minority Health & Health Disparities (NIMHD)
RP Tamura, K (corresponding author), Natl Inst Minor Hlth & Hlth Dispar, Populat & Community Hlth Sci Branch, Div Intramural Res, Sociospatial Determinants Hlth SSDH Lab,NIH, Bldg 3,3 Ctr Dr, Bethesda, MD 20892 USA.
EM kosuke.tamura@nih.gov
RI PowellWiley, Tiffany/MCY-2981-2025; Zennk, Shannon/D-4096-2018; Tamura,
   Kosuke/S-9498-2019; Mohammad, Moniruzzaman/H-8503-2019
OI Tamura, Kosuke/0000-0002-4920-2856; Jones, Kelly/0000-0002-1552-7847;
   Reid, Lauren/0000-0003-1021-8364; Mohammad,
   Moniruzzaman/0000-0003-2144-7111; Powell-Wiley, Tiffany
   M./0000-0001-9488-4131
FU Health Laboratory at the National Institute on Minority Health and
   Health Disparities (NIMHD); National Institutes of Health (NIH)
FX The authors thank the staff and participants of the JHS. Dr Reid had
   worked on this study while she was a postdoctoral fellow at the
   Neighborhoods and Health Laboratory at the National Institute on
   Minority Health and Health Disparities (NIMHD) and the National
   Institutes of Health (NIH).
CR Adamus-Leach HJ, 2012, ENVIRON HEALTH INSIG, V6, DOI 10.4137/EHI.S10655
   Baldock K, 2012, J ENVIRON PUBLIC HEA, V2012, DOI 10.1155/2012/589409
   Baldock KL, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0201336
   Barber S, 2016, J RACIAL ETHN HEALTH, V3, P444, DOI 10.1007/s40615-015-0157-0
   Barnett A, 2022, ENVIRON HEALTH-GLOB, V21, DOI 10.1186/s12940-022-00894-4
   Bell CN, 2018, ANN EPIDEMIOL, V28, P147, DOI 10.1016/j.annepidem.2017.12.007
   Brewer LC, 2018, J AM HEART ASSOC, V7, DOI 10.1161/JAHA.118.008855
   Browning CR, 2012, SOC SCI MED, V75, P1271, DOI 10.1016/j.socscimed.2012.03.027
   Cardel MI, 2021, ANN BEHAV MED, V55, P266, DOI 10.1093/abm/kaaa050
   Cardel MI, 2018, PSYCHONEUROENDOCRINO, V90, P141, DOI 10.1016/j.psyneuen.2018.02.014
   Carnethon MR, 2017, CIRCULATION, V136, pE393, DOI 10.1161/CIR.0000000000000534
   Carpenter MA, 2004, AM J MED SCI, V328, P131, DOI 10.1097/00000441-200409000-00001
   Chichlowska KL, 2008, PSYCHOSOM MED, V70, P986, DOI 10.1097/PSY.0b013e318183a491
   Clark CR, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0063254
   Clark LT, 2007, CLIN CARDIOL, V30, P161, DOI 10.1002/clc.20003
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Dallongeville J, 2005, DIABETES CARE, V28, P409, DOI 10.2337/diacare.28.2.409
   Dubbert PM, 2005, ETHNIC DIS, V15, pS56
   Egede JK, 2022, AM J HEALTH PROMOT, V36, P269, DOI 10.1177/08901171211050369
   Espinola-Klein C, 2011, FRONT BIOSCI-LANDMRK, V16, P1663, DOI 10.2741/3812
   Ford ES, 2008, DIABETES CARE, V31, P1898, DOI 10.2337/dc08-0423
   Gary-Webb TL, 2020, BMC PUBLIC HEALTH, V20, DOI 10.1186/s12889-019-8119-9
   Gebreab SY, 2017, HEALTH PLACE, V43, P128, DOI 10.1016/j.healthplace.2016.12.001
   Grundy SM, 2018, EUR J CLIN INVEST, V48, DOI 10.1111/eci.12941
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Gurka MJ, 2014, METABOLISM, V63, P218, DOI 10.1016/j.metabol.2013.10.006
   Hayes A. F., 2017, INTRO MEDIATION MODE
   Hayes AF, 2015, MULTIVAR BEHAV RES, V50, P1, DOI 10.1080/00273171.2014.962683
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Johnson DA, 2016, SLEEP, V39, P1411, DOI 10.5665/sleep.5974
   Kanchi R, 2018, J URBAN HEALTH, V95, P801, DOI 10.1007/s11524-018-0287-x
   Kepper MM, 2019, INT J BEHAV NUTR PHY, V16, DOI 10.1186/s12966-019-0873-7
   Loucks EB, 2007, ANN EPIDEMIOL, V17, P19, DOI 10.1016/j.annepidem.2006.07.002
   Messer LC, 2013, J URBAN HEALTH, V90, P857, DOI 10.1007/s11524-012-9743-1
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   Mosley-Johnson E, 2022, BMJ OPEN, V12, DOI 10.1136/bmjopen-2021-060263
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Mujahid MS, 2007, AM J EPIDEMIOL, V165, P858, DOI 10.1093/aje/kwm040
   Myers J, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071652
   Osei K, 2010, CURR DIABETES REP, V10, P199, DOI 10.1007/s11892-010-0116-4
   Payne TJ, 2005, ETHNIC DIS, V15, pS38
   Ramphal Lilly, 2014, Proc (Bayl Univ Med Cent), V27, P92
   Roberts LC, 2021, J URBAN HEALTH, V98, P130, DOI 10.1007/s11524-020-00499-7
   Robinette JW, 2018, SOC SCI MED, V198, P70, DOI 10.1016/j.socscimed.2017.12.025
   Saelens BE, 2003, AM J PUBLIC HEALTH, V93, P1552, DOI 10.2105/AJPH.93.9.1552
   Scott SB, 2018, SOC SCI MED, V200, P262, DOI 10.1016/j.socscimed.2017.11.010
   Shmool JLC, 2015, AM J COMMUN PSYCHOL, V56, P145, DOI 10.1007/s10464-015-9736-9
   Sims KD, 2020, AM J PREV MED, V58, P199, DOI 10.1016/j.amepre.2019.09.019
   Smitherman TA, 2009, J PHYS ACT HEALTH, V6, pS124, DOI 10.1123/jpah.6.s1.s124
   Stappers NEH, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15061062
   Strobl H, 2020, FRONT PUBLIC HEALTH, V8, DOI 10.3389/fpubh.2020.00004
   Tamura Kosuke, 2022, Sleep Adv, V3, pzpac032, DOI 10.1093/sleepadvances/zpac032
   Tamura K, 2020, INT J BEHAV NUTR PHY, V17, DOI 10.1186/s12966-020-00991-y
   Taylor HA, 2005, ETHNIC DIS, V15, pS1
   Timpson NJ, 2005, LANCET, V366, P1954, DOI 10.1016/S0140-6736(05)67786-0
   Yang CJ, 2022, BMC GERIATR, V22, DOI 10.1186/s12877-022-03672-6
NR 56
TC 1
Z9 1
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD JAN 7
PY 2025
VL 14
IS 1
AR e035216
DI 10.1161/JAHA.124.035216
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA R3P3W
UT WOS:001390605800001
PM 39704229
DA 2025-06-11
ER

PT J
AU Yubero-Serrano, EM
   Delgado-Lista, J
   Peña-Orihuela, P
   Perez-Martinez, P
   Fuentes, F
   Marin, C
   Tunez, I
   Tinahones, FJ
   Perez-Jimenez, F
   Roche, HM
   Lopez-Miranda, J
AF Maria Yubero-Serrano, Elena
   Delgado-Lista, Javier
   Pena-Orihuela, Patricia
   Perez-Martinez, Pablo
   Fuentes, Francisco
   Marin, Carmen
   Tunez, Isaac
   Jose Tinahones, Francisco
   Perez-Jimenez, Francisco
   Roche, Helen M.
   Lopez-Miranda, Jose
TI Oxidative stress is associated with the number of components of
   metabolic syndrome: LIPGENE study
SO EXPERIMENTAL AND MOLECULAR MEDICINE
LA English
DT Article
DE cardiovascular risk factors; endothelial dysfunction; LIPGENE study;
   metabolic syndrome; oxidative stress; redox state
ID INSULIN-RESISTANCE; RISK-FACTORS; CARDIOVASCULAR-DISEASE; ENDOTHELIAL
   FUNCTION; ANTIOXIDANT ENZYMES; INFLAMMATION; SENSITIVITY; OBESITY;
   IMPACT; CELLS
AB Previous evidence supports the important role that oxidative stress (OxS) plays in metabolic syndrome (MetS)-related manifestations. We determined the relationship between the number of MetS components and the degree of OxS in MetS patients. In this comparative cross-sectional study from the LIPGENE cohort, a total of 91 MetS patients (43 men and 48 women; aged between 45 and 68 years) were divided into four groups based on the number of MetS components: subjects with 2, 3, 4 and 5 MetS components (n = 20, 31, 28 and 12, respectively). We measured ischemic reactive hyperemia (IRH), plasma levels of soluble vascular cell adhesion molecule-1 (sVCAM-1), total nitrite, lipid peroxidation products (LPO), hydrogen peroxide (H2O2), superoxide dismutase ( SOD) and glutathione peroxidase (GPx) plasma activities. sVCAM-1, H2O2 and LPO levels were lower in subjects with 2 or 3 MetS components than subjects with 4 or 5 MetS components. IRH and total nitrite levels were higher in subjects with 2 or 3 MetS components than subjects with 4 or 5 MetS components. SOD and GPx activities were lower in subjects with 2 MetS components than subjects with 4 or 5 MetS components. Waist circumference, weight, age, homeostatic model assessment-beta, triglycerides (TGs), high-density lipoprotein and sVCAM-1 levels were significantly correlated with SOD activity. MetS subjects with more MetS components may have a higher OxS level. Furthermore, association between SOD activity and MetS components may indicate that this variable could be the most relevant OxS biomarker in patients suffering from MetS and could be used as a predictive tool to determine the degree of the underlying OxS in MetS.
C1 [Maria Yubero-Serrano, Elena; Delgado-Lista, Javier; Pena-Orihuela, Patricia; Perez-Martinez, Pablo; Fuentes, Francisco; Marin, Carmen; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Univ Cordoba, Reina Sofia Univ Hosp, IMIBIC, Lipids & Atherosclerosis Unit, E-14004 Cordoba, Spain.
   [Maria Yubero-Serrano, Elena; Delgado-Lista, Javier; Pena-Orihuela, Patricia; Perez-Martinez, Pablo; Fuentes, Francisco; Marin, Carmen; Jose Tinahones, Francisco; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
   [Tunez, Isaac] Univ Cordoba, Fac Med, Dept Biochem & Mol Biol IMIBIC, E-14004 Cordoba, Spain.
   [Jose Tinahones, Francisco] Hosp Virgen de la Victoria, Dept Endocrinol, Biomed Res Lab, Malaga, Spain.
   [Roche, Helen M.] Univ Coll Dublin, UCD Conway Inst, Sch Publ Hlth & Populat Sci, Nutrigen Res Grp, Dublin 2, Ireland.
C3 Universidad de Cordoba; Hospital Universitario Reina Sofia - Cordoba;
   CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Instituto de
   Salud Carlos III; Universidad de Cordoba; University College Dublin
RP Lopez-Miranda, J (corresponding author), Univ Cordoba, Reina Sofia Univ Hosp, IMIBIC, Lipids & Atherosclerosis Unit, Avda Menendez Pidal S-N, E-14004 Cordoba, Spain.
EM jlopezmir@uco.es
RI Roche, Helen/AAF-4164-2019; Fuentes-Jimenez, Francisco
   Jose/HTM-0138-2023; Yubero-Serrano, Elena/H-4832-2013; Marin Hinojosa,
   Carmen/AFO-1294-2022; Delgado-Lista, Javier/KAM-7412-2024; Jimenez,
   Francisco/AAJ-9559-2021; Lopez-Miranda, Jose/Y-8306-2019; Tinahones,
   Francisco/AAB-2882-2020; FUENTES JIMENEZ, FRANCISCO/G-4311-2016; Perez
   Martinez, Pablo/AEL-6176-2022
OI Pena Orihuela, Patricia J/0009-0009-9970-043X; Lopez-Miranda,
   Jose/0000-0002-8844-0718; Delgado Lista, Francisco
   Javier/0000-0002-2982-2716; FUENTES JIMENEZ,
   FRANCISCO/0000-0002-4584-7366; Yubero-Serrano, Elena
   M/0000-0002-2733-5359; Roche, Helen/0000-0002-0628-3318; Tinahones,
   Francisco J/0000-0001-6871-4403; Perez Martinez,
   Pablo/0000-0001-7716-8117; Perez Jimenez, Francisco/0000-0001-9808-1280;
   Perez-Jimenez, Francisco/0000-0001-7499-7681
FU Ministerio de Ciencia e Innovacion [AGL2006-01979, AGL2009-12270]; CIBER
   Fisiopatologia de la Obesidad y Nutrition [CB06/03/0047]; Consejeria de
   Innovacion, Ciencia y Empresa, Junta de Andalucia [P06-CTS-01425,
   CVI-7450]; Consejeria de Salud, Junta de Andalucia [06/128, 07/43,
   PI0193/2009, 06/129]
FX This research was supported partly by grants from the Ministerio de
   Ciencia e Innovacion (AGL2006-01979, AGL2009-12270 to JL-M),
   ('CB06/03/0047-CIBER Fisiopatologia de la Obesidad y Nutrition' is an
   ISCIII grant awarded to FP-J), Consejeria de Innovacion, Ciencia y
   Empresa, Junta de Andalucia (P06-CTS-01425 and CVI-7450 to JL-M);
   Consejeria de Salud, Junta de Andalucia (06/128, 07/43, PI0193/2009 to
   JL-M, 06/129 to FP-J).
CR Abdilla N, 2007, J HUM HYPERTENS, V21, P68, DOI 10.1038/sj.jhh.1002105
   Aizawa K, 2009, DIABETES VASC DIS RE, V6, P181, DOI 10.1177/1479164109336375
   Arsova-Sarafinovska Z, 2009, CLIN BIOCHEM, V42, P1228, DOI 10.1016/j.clinbiochem.2009.05.009
   BUCOLO G, 1973, CLIN CHEM, V19, P476
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Chaves FJ, 2007, AM J HYPERTENS, V20, P62, DOI 10.1016/j.amjhyper.2006.06.006
   Chen SS, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0050456, 10.1371/journal.pone.0049275, 10.1371/journal.pone.0045763, 10.1371/journal.pone.0036784]
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Conwell LS, 2004, DIABETES CARE, V27, P314, DOI 10.2337/diacare.27.2.314
   Dulak J, 1999, J PHYSIOL PHARMACOL, V50, P429
   Erdelmeier I, 1998, CHEM RES TOXICOL, V11, P1184, DOI 10.1021/tx970180z
   FLOHE L, 1984, METHOD ENZYMOL, V105, P114
   Fortuño A, 2006, DIABETES, V55, P209, DOI 10.2337/diabetes.55.1.209
   Fujita K, 2006, CIRC J, V70, P1437, DOI 10.1253/circj.70.1437
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Grattagliano I, 2008, J NUTR BIOCHEM, V19, P491, DOI 10.1016/j.jnutbio.2007.06.011
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   HIRAMATSU K, 1988, DIABETES, V37, P832, DOI 10.2337/diabetes.37.6.832
   Holmlund A, 2002, ATHEROSCLEROSIS, V165, P271, DOI 10.1016/S0021-9150(02)00234-4
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Kim M, 2012, METABOLISM CLIN EXPT
   Levey AS, 2009, ANN INTERN MED, V150, P604, DOI 10.7326/0003-4819-150-9-200905050-00006
   Mancia G, 2003, J HYPERTENS, V21, P1011, DOI 10.1097/01.hjh.0000059051.65882.32
   Matés JM, 1999, CLIN BIOCHEM, V32, P595, DOI 10.1016/S0009-9120(99)00075-2
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McNeill AM, 2005, DIABETES CARE, V28, P385, DOI 10.2337/diacare.28.2.385
   Mokdad AH, 2003, JAMA-J AM MED ASSOC, V289, P76, DOI 10.1001/jama.289.1.76
   NEBOT C, 1993, ANAL BIOCHEM, V214, P442, DOI 10.1006/abio.1993.1521
   Nicolson GL, 2007, J CELL BIOCHEM, V100, P1352, DOI 10.1002/jcb.21247
   Perez-Martinez P, 2010, ATHEROSCLEROSIS, V209, P533, DOI 10.1016/j.atherosclerosis.2009.09.023
   Reaven G, 2002, CIRCULATION, V106, P286, DOI 10.1161/01.CIR.0000019884.36724.D9
   Ricart-Jané D, 2002, NITRIC OXIDE-BIOL CH, V6, P178, DOI 10.1006/niox.2001.0392
   Rifai N, 1999, CLIN CHEM, V45, P2136
   Sánchez-Rodríguez MA, 2010, ANN NUTR METAB, V56, P302, DOI 10.1159/000309601
   Skalicky J, 2008, CLIN CHEM LAB MED, V46, P499, DOI 10.1515/CCLM.2008.096
   Tierney AC, 2011, INT J OBESITY, V35, P800, DOI 10.1038/ijo.2010.209
   van Etten RW, 2002, DIABETOLOGIA, V45, P1004, DOI 10.1007/s00125-002-0862-1
   Van Guilder GP, 2006, OBESITY, V14, P2127, DOI 10.1038/oby.2006.248
   WARNICK GR, 1982, CLIN CHEM, V28, P1379
   Zhu H, 2008, EXP BIOL MED, V233, P753, DOI 10.3181/0801-RM-5
NR 41
TC 78
Z9 86
U1 0
U2 12
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1226-3613
EI 2092-6413
J9 EXP MOL MED
JI Exp. Mol. Med.
PD JUN
PY 2013
VL 45
AR e28
DI 10.1038/emm.2013.53
PG 7
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine
GA 174VT
UT WOS:000321185500003
PM 23788131
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chaldakov, GN
   Tonchev, AB
   Aloe, L
AF Chaldakov, George N.
   Tonchev, Anton B.
   Aloe, Luigi
TI NGF and BDNF: from nerves to adipose tissue, from neurokines to
   metabokines
SO RIVISTA DI PSICHIATRIA
LA English
DT Review
DE adipokines; neurotrophins; synaptotrophic effects; metabotrophic
   effects; ampakines; deacetylase; calorie restriction
ID NEUROTROPHIC FACTOR BDNF; ADIPOKINE GENE-EXPRESSION; TYPE-2
   DIABETES-MELLITUS; GROWTH-FACTOR NGF; ALZHEIMERS-DISEASE; METABOLIC
   SYNDROME; PSYCHIATRIC-DISORDERS; NEURONAL PLASTICITY; TOPICAL
   APPLICATION; GLUCOSE-METABOLISM
AB Neurotrophins, particularly, NGF and BDNF are now well recognized to mediate a dizzying number of trophobiological effects, ranging from the Rita Levi-Montalcini's neurotrophic through immunotrophic to metabotrophic effects. These are implicated in the pathogenesis of various diseases including neuropsychiatric and cardiometabolic diseases, such as dementia, depression, type 2 diabetes and obesity that may express a common phenotype and coexistence. Recently, adipobiology (adiposcience) as become a focus of numerous studies showing that the adipose tissue is the body's largest endocrine organ producing multiple signaling proteins, including NGF and BDNF, all these dubbed adipokines. On the basis of our and other authors' evidence that low NGF and/or BDNF levels are found in cardiometabolic diseases (atherosclerosis, obesity, type 2 diabetes, metabolic syndrome), a hypothesis of a critical role of neuro-metabotrophic deficit in the pathogenesis of these diseases has been raised. Since NGF and BDNF also exerts various synaptotrophic effects involved in cognitive enhancement, this hypothesis might also be related to neuropsychiatric diseases such as dementia, depression, schizophrenia, autism, Rett syndrome, anorexia nervosa, and bulimia nervosa. Finally, NGF- and BDNF-based therapeutic approach, including ampakines, antidepressants, selective deacetylase inhibitors, statins, peroxisome proliferator-activated receptor gamma agonists, and "brain food" and calorie restriction, is outlined.
C1 [Chaldakov, George N.; Tonchev, Anton B.] Med Univ, Div Cell Biol, Varna, Bulgaria.
   [Aloe, Luigi] European Brain Res Inst, Natl Res Council, Inst Neurobiol & Mol Med, Rome, Italy.
C3 Medical University Varna
RP Chaldakov, GN (corresponding author), Med Univ, Div Cell Biol, Varna, Bulgaria.
EM chaldakov@yahoo.com
RI Tonchev, Anton/LKK-5568-2024
CR Abe T, 1997, CIRCULATION, V95, P213, DOI 10.1161/01.CIR.95.1.213
   Ahmed F, 2008, BRAIN RES, V1227, P1, DOI 10.1016/j.brainres.2008.05.086
   Allam AR, 2006, LIPIDS HEALTH DIS, V5, DOI 10.1186/1476-511X-5-28
   ALOE L, 1986, P NATL ACAD SCI USA, V83, P6184, DOI 10.1073/pnas.83.16.6184
   Aloe L, 2004, PROG BRAIN RES, V146, P515
   ALOE L, 1977, BRAIN RES, V133, P358, DOI 10.1016/0006-8993(77)90772-7
   Aloe L, 2001, CURR PHARM DESIGN, V7, P113, DOI 10.2174/1381612013398383
   ALOE L, 1999, BIOMEDICAL REV, V10
   Aloe L, 2008, PHARMACOL RES, V57, P253, DOI 10.1016/j.phrs.2008.01.010
   ANGELETTI PU, 1968, ADV ENZYMOL RAMB, V31, P51
   Angelucci F, 2004, PROG BRAIN RES, V146, P151, DOI 10.1016/S0079-6123(03)46011-1
   Anghileri E, 2008, STEM CELLS DEV, V17, P909, DOI 10.1089/scd.2007.0197
   [Anonymous], PROGR BRAIN RES
   Arvanitakis Z, 2008, NEUROLOGY, V70, P1795, DOI 10.1212/01.wnl.0000288181.00826.63
   Azoulay D, 2008, J NEUROIMMUNOL, V195, P186, DOI 10.1016/j.jneuroim.2008.01.010
   Bariohay B, 2005, ENDOCRINOLOGY, V146, P5612, DOI 10.1210/en.2005-0419
   Beydoun MA, 2008, OBES REV, V9, P204, DOI 10.1111/j.1467-789X.2008.00473.x
   Biessels GJ, 2006, LANCET NEUROL, V5, P64, DOI 10.1016/S1474-4422(05)70284-2
   Bifulco Maurizio, 2008, Expert Rev Neurother, V8, P827, DOI 10.1586/14737175.8.5.827
   Blandini F, 2006, CEPHALALGIA, V26, P136, DOI 10.1111/j.1468-2982.2005.01006.x
   Bono F, 1997, FEBS LETT, V416, P243, DOI 10.1016/S0014-5793(97)01215-5
   Botchkarev VA, 2004, PROG BRAIN RES, V146, P493
   Brown R, 2008, NEUROSCI LETT, V432, P73, DOI 10.1016/j.neulet.2007.12.008
   Bulló M, 2005, AM J PHYSIOL-ENDOC M, V289, pE62, DOI 10.1152/ajpendo.00008.2005
   Bulló M, 2007, EUR J ENDOCRINOL, V157, P303, DOI 10.1530/EJE-06-0716
   Calamandrei G, 2000, DEV MED CHILD NEUROL, V42, P746, DOI 10.1017/S0012162200001389
   Caporali A, 2008, CELL DEATH DIFFER, V15, P299, DOI 10.1038/sj.cdd.4402263
   Catalan V, 2006, BIOMED REV, V17, P43
   Chaldakov GN, 2007, CURR PHARM DESIGN, V13, P2176, DOI 10.2174/138161207781039616
   Chaldakov George N, 2003, Med Sci Monit, V9, pHY19
   Chaldakov GN, 2004, PROG BRAIN RES, V146, P279, DOI 10.1016/S0079-6123(03)46018-4
   Chaldakov GN, 2003, ARCH ITAL BIOL, V141, P89
   Chaldakov GN, 2003, CURR PHARM DESIGN, V9, P1023, DOI 10.2174/1381612033455152
   CHALDAKOV GN, J ENDOCARDI IN PRESS
   Chang QA, 2006, NEURON, V49, P341, DOI 10.1016/j.neuron.2005.12.027
   Chao MV, 2006, CLIN SCI, V110, P167, DOI 10.1042/CS20050163
   Chapleau CA, 2008, J NEUROSCI METH, V169, P182, DOI 10.1016/j.jneumeth.2007.12.006
   Chen Y, 2007, J ANDROL, V28, P306, DOI 10.2164/jandrol.106.000794
   Corsi MM, 2006, NEUROENDOCRINOL LETT, V27, P773
   Craft S, 2007, CURR ALZHEIMER RES, V4, P147, DOI 10.2174/156720507780362137
   Danysz Wojciech, 2002, Curr Opin Investig Drugs, V3, P1081
   Di Fausto V, 2007, EUR J NEUROSCI, V26, P2473, DOI 10.1111/j.1460-9568.2007.05883.x
   Dicou E, 2008, J NEUROIMMUNOL, V194, P143, DOI 10.1016/j.jneuroim.2007.11.002
   Dicou E, 2006, BIOCHEM BIOPH RES CO, V347, P833, DOI 10.1016/j.bbrc.2006.06.171
   Dompierre JP, 2007, J NEUROSCI, V27, P3571, DOI 10.1523/JNEUROSCI.0037-07.2007
   Fahnestock M, 2004, PROG BRAIN RES, V146, P101, DOI 10.1016/S0079-6123(03)46007-X
   Falcini F, 1996, J RHEUMATOL, V23, P1798
   Fiore M, 2008, ANN I SUPER SANITA, V44, P167
   Fujinami A, 2008, CLIN BIOCHEM, V41, P812, DOI 10.1016/j.clinbiochem.2008.03.003
   GEERTS H, 1998, DRUGS, V1, P694
   Generini S, 2004, EXP CLIN ENDOCR DIAB, V112, P542, DOI 10.1055/s-2004-821313
   Geroldi D, 2006, MED HYPOTHESES, V67, P195, DOI 10.1016/j.mehy.2006.02.001
   Gómez-Pinilla F, 2008, NAT REV NEUROSCI, V9, P568, DOI 10.1038/nrn2421
   Góra-Kupilas K, 2005, FOLIA NEUROPATHOL, V43, P31
   Groves JO, 2007, MOL PSYCHIATR, V12, P1079, DOI 10.1038/sj.mp.4002075
   Guzik TJ, 2007, J PHYSIOL PHARMACOL, V58, P591
   Hansen-Algenstaedt N, 2006, HISTOCHEM CELL BIOL, V125, P637, DOI 10.1007/s00418-005-0111-z
   Hasan W, 2006, BRAIN RES, V1124, P142, DOI 10.1016/j.brainres.2006.09.054
   Hashimoto K, 2005, PROG NEURO-PSYCHOPH, V29, P499, DOI 10.1016/j.pnpbp.2005.01.007
   Huang YF, 2002, J NEUROSCI, V22, P8422
   Iacobellis G, 2007, CURR PHARM DESIGN, V13, P2180
   Jeanneteau Freddy, 2006, Novartis Found Symp, V276, P181
   Jiang QG, 2008, CNS DRUGS, V22, P1, DOI 10.2165/00023210-200822010-00001
   Kangavari S, 2006, HEART RHYTHM, V3, P1150, DOI 10.1016/j.hrthm.2006.06.033
   Kanoski SE, 2007, BEHAV BRAIN RES, V182, P57, DOI 10.1016/j.bbr.2007.05.004
   Karamoysoyli E, 2008, DIABETES, V57, P181, DOI 10.2337/db07-0895
   Koizumi H, 2006, EUR J NEUROSCI, V24, P2335, DOI 10.1111/j.1460-9568.2006.05094.x
   Kolotkin RL, 2008, OBESITY, V16, P749, DOI 10.1038/oby.2007.133
   Kozisek ME, 2008, PHARMACOL THERAPEUT, V117, P30, DOI 10.1016/j.pharmthera.2007.07.001
   Krabbe KS, 2007, DIABETOLOGIA, V50, P431, DOI 10.1007/s00125-006-0537-4
   Landreth G, 2007, CURR ALZHEIMER RES, V4, P159, DOI 10.2174/156720507780362092
   Larrieta ME, 2006, EXP BIOL MED, V231, P396, DOI 10.1177/153537020623100405
   Lazarovici P, 2006, CURR PHARM DESIGN, V12, P2609, DOI 10.2174/138161206777698738
   Lebrun B, 2006, AUTON NEUROSCI-BASIC, V126, P30, DOI 10.1016/j.autneu.2006.02.027
   Lester-Coll N, 2006, J ALZHEIMERS DIS, V9, P13
   Levi-Montalcini R, 2000, SCIENCE, V287, P809, DOI 10.1126/science.287.5454.809
   Levi-Montalcini R, 1998, NEUROREPORT, V9, pR71
   LEVIMONTALCINI R, 1987, SCIENCE, V237, P1154, DOI 10.1126/science.3306916
   LeviMontalcini R, 1996, TRENDS NEUROSCI, V19, P514, DOI 10.1016/S0166-2236(96)10058-8
   Li Lin, 2007, Neurosci Bull, V23, P58, DOI 10.1007/s12264-007-0009-y
   Li L, 2007, BRAIN RES REV, V56, P384, DOI 10.1016/j.brainresrev.2007.09.001
   Li ZG, 2007, DIABETES, V56, P1817, DOI 10.2337/db07-0171
   Lu B, 2004, PROG BRAIN RES, V146, P137, DOI 10.1016/S0079-6123(03)46010-X
   Lu Bai, 2008, Novartis Found Symp, V289, P119
   Lu XY, 2007, CURR OPIN PHARMACOL, V7, P648, DOI 10.1016/j.coph.2007.10.010
   Luchsinger JA, 2007, CURR ALZHEIMER RES, V4, P127, DOI 10.2174/156720507780362100
   Lukashev D, 2004, J IMMUNOL, V173, P21, DOI 10.4049/jimmunol.173.1.21
   Lynch G, 2006, CURR OPIN PHARMACOL, V6, P82, DOI 10.1016/j.coph.2005.09.005
   Lynch G, 2008, EUR J PHARMACOL, V585, P2, DOI 10.1016/j.ejphar.2007.11.082
   Lynch G, 2006, TRENDS NEUROSCI, V29, P554, DOI 10.1016/j.tins.2006.07.007
   Makar TK, 2008, J NEUROL SCI, V270, P70, DOI 10.1016/j.jns.2008.02.011
   Manni L, 2005, INT J CARDIOL, V102, P169, DOI 10.1016/j.ijcard.2004.10.041
   Manni LG, 2007, NEUROSCI LETT, V426, P39, DOI 10.1016/j.neulet.2007.08.015
   MANNING S, 2007, BIOMEDICAL REV, V18, P59
   Martinowich K, 2008, NEUROPSYCHOPHARMACOL, V33, P73, DOI 10.1038/sj.npp.1301571
   Matsuda H, 1998, J EXP MED, V187, P297, DOI 10.1084/jem.187.3.297
   Mattson MP, 2003, J NEUROCHEM, V84, P417, DOI 10.1046/j.1471-4159.2003.01586.x
   Mercader JM, 2007, NEUROPSYCHOBIOLOGY, V56, P185, DOI 10.1159/000120623
   Micera A, 2001, P NATL ACAD SCI USA, V98, P6162, DOI 10.1073/pnas.101130898
   Mojsilovic-Petrovic J, 2005, NEURODEGENER DIS, V2, P160, DOI 10.1159/000089621
   Molteni R, 2002, NEUROSCIENCE, V112, P803, DOI 10.1016/S0306-4522(02)00123-9
   Monteleone P, 2005, PSYCHOL MED, V35, P897, DOI 10.1017/S0033291704003368
   Muangman P, 2004, WOUND REPAIR REGEN, V12, P44, DOI 10.1111/j.1067-1927.2004.012110.x-1
   MUKHERJEE SP, 1982, BIOCHEM PHARMACOL, V31, P3163, DOI 10.1016/0006-2952(82)90545-7
   Nelson TJ, 2005, BIOCHEM SOC T, V33, P1033, DOI 10.1042/BST0331033
   Nicholson JR, 2007, J NEUROENDOCRINOL, V19, P974, DOI 10.1111/j.1365-2826.2007.01610.x
   NIKOLOVA V, 2007, BIOMEDICAL REV, V18, P89
   O'Brian CA, 2006, OXIDAT STRESS DIS, V20, P133
   Ognibene E, 2008, PROG NEURO-PSYCHOPH, V32, P1269, DOI 10.1016/j.pnpbp.2008.03.023
   OTTEN U, 1995, INT J DEV NEUROSCI, V13, P147, DOI 10.1016/0736-5748(95)00016-A
   Park KS, 2008, AM J OPHTHALMOL, V145, P432, DOI 10.1016/j.ajo.2007.11.011
   Pasinetti Giulio Maria, 2007, V35, P159
   Perry TA, 2004, CURR DRUG TARGETS, V5, P565, DOI 10.2174/1389450043345245
   Petry NM, 2008, PSYCHOSOM MED, V70, P288, DOI 10.1097/PSY.0b013e3181651651
   Philis-Tsimikas A, 2007, DIABETOLOGIA, V50, pS404
   Plunet WT, 2008, EXP NEUROL, V213, P28, DOI 10.1016/j.expneurol.2008.04.011
   Post JI, 2008, AMYOTROPH LATERAL SC, V9, P149, DOI 10.1080/17482960801934015
   Raab S, 2007, ACTA NEUROPATHOL, V113, P607, DOI 10.1007/s00401-007-0228-3
   Rantamäki T, 2008, EXPERT OPIN THER TAR, V12, P705, DOI [10.1517/14728222.12.6.705 , 10.1517/14728220802121472]
   Rao AA, 2007, MED HYPOTHESES, V69, P1272, DOI 10.1016/j.mehy.2007.03.032
   Reid PC, 2007, J CELL MOL MED, V11, P383, DOI 10.1111/j.1582-4934.2007.00054.x
   Rex CS, 2007, J NEUROSCI, V27, P3017, DOI 10.1523/JNEUROSCI.4037-06.2007
   Sarchielli P, 2007, J PAIN, V8, P737, DOI 10.1016/j.jpain.2007.05.002
   SCARISBRICK IA, 1993, J NEUROSCI, V13, P875
   Schäaffler A, 2006, NAT CLIN PRACT ENDOC, V2, P374, DOI 10.1038/ncpendmet0197
   Schäffler A, 2005, NEUROPEPTIDES, V39, P363, DOI 10.1016/j.npep.2005.06.003
   Schjetnan AGP, 2007, REV NEUROLOGIA, V45, P409, DOI 10.33588/rn.4507.2006551
   Schroeder FA, 2007, BIOL PSYCHIAT, V62, P55, DOI 10.1016/j.biopsych.2006.06.036
   Schulte-Herbrüggen O, 2007, CURR MED CHEM, V14, P2318, DOI 10.2174/092986707781745578
   Shintani F, 1999, BIOMED REV, V10, P69
   Shobab LA, 2005, LANCET NEUROL, V4, P841, DOI 10.1016/S1474-4422(05)70248-9
   Sima Anders A F, 2006, Rev Diabet Stud, V3, P161, DOI 10.1900/RDS.2006.3.161
   Simon GE, 2006, ARCH GEN PSYCHIAT, V63, P824, DOI 10.1001/archpsyc.63.7.824
   Snider WD, 1996, MOL CELL NEUROSCI, V7, P433, DOI 10.1006/mcne.1996.0031
   Sornelli F., 2007, Biomed. Rev, V18, P85, DOI [10.14748/bmr.v18.72, DOI 10.14748/BMR.V18.72]
   Soule J, 2006, BIOCHEM SOC T, V34, P600, DOI 10.1042/BST0340600
   Sposato V, 2007, ARCH ITAL BIOL, V145, P87
   Sun MK, 2008, NEUROREPORT, V19, P355, DOI 10.1097/WNR.0b013e3282f519c7
   Tang BL, 2008, BIOCHEM BIOPH RES CO, V368, P181, DOI 10.1016/j.bbrc.2008.01.063
   Tang SW, 2008, NEUROSCI LETT, V431, P62, DOI 10.1016/j.neulet.2007.11.019
   Taniura H, 2006, HISTOL HISTOPATHOL, V21, P785, DOI 10.14670/HH-21.785
   TONCHEV AB, 2007, BIOMEDICAL REV, V18, P69
   Tongiorgi E, 2008, NEUROSCI RES, V61, P335, DOI 10.1016/j.neures.2008.04.013
   Tore F., 2007, Immunology Endocrine & Metabolic Agents in Medicinal Chemistry, V7, P149, DOI 10.2174/187152207780363712
   Trayhurn P, 2004, BRIT J NUTR, V92, P347, DOI 10.1079/BJN20041213
   Tsai SJ, 2007, MED HYPOTHESES, V68, P1296, DOI 10.1016/j.mehy.2006.09.043
   Tsankova NM, 2006, NAT NEUROSCI, V9, P519, DOI 10.1038/nn1659
   Tyler WJ, 2002, NEUROSCIENTIST, V8, P524, DOI 10.1177/1073858402238511
   Villoslada P, 2004, PROG BRAIN RES, V146, P403
   Wang BH, 2005, AM J PHYSIOL-ENDOC M, V288, pE731, DOI 10.1152/ajpendo.00475.2004
   Wang J, 2005, FASEB J, V19, P659, DOI 10.1096/fj.04-3182fje
   Watson GS, 2003, CNS DRUGS, V17, P27, DOI 10.2165/00023210-200317010-00003
   Whitfield JF, 2006, EXPERT OPIN INV DRUG, V15, P1479, DOI 10.1517/13543784.15.12.1479
   Whitmer RA, 2007, CURR ALZHEIMER RES, V4, P117, DOI 10.2174/156720507780362065
   Wilkinson M, 2007, NEUROENDOCRINOLOGY, V86, P191, DOI 10.1159/000108635
   WILLIAMS LR, 1991, EXP NEUROL, V113, P31, DOI 10.1016/0014-4886(91)90143-Z
   Wu HT, 2008, J NEUROTRAUM, V25, P130, DOI 10.1089/neu.2007.0369
   Xiong HQ, 2008, NEUROBIOL DIS, V29, P422, DOI 10.1016/j.nbd.2007.10.005
   Yamanaka M, 2007, DIABETES OBES METAB, V9, P879, DOI 10.1111/j.1463-1326.2006.00675.x
   Yamanaka M, 2008, J BIOSCI BIOENG, V105, P395, DOI 10.1263/jbb.105.395
   ZHANG YY, 1994, NATURE, V372, P425, DOI 10.1038/372425a0
NR 161
TC 81
Z9 91
U1 0
U2 14
PU PENSIERO SCIENTIFICO EDITOR
PI ROME
PA VIA BRADANO 3/C, 00199 ROME, ITALY
SN 0035-6484
EI 2038-2502
J9 RIV PSICHIATR
JI Riv. Psichiatr.
PD MAR-APR
PY 2009
VL 44
IS 2
BP 79
EP 87
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 439UT
UT WOS:000265653500002
PM 20066808
DA 2025-06-11
ER

PT J
AU Wärdig, RE
   Bachrach-Lindström, M
   Foldemo, A
   Lindström, T
   Hultsjö, S
AF Wardig, Rikard Erik
   Bachrach-Lindstrom, Margareta
   Foldemo, Anniqa
   Lindstrom, Torbjorn
   Hultsjo, Sally
TI Prerequisites for A Healthy Lifestyle-Experiences of Persons with
   Psychosis
SO ISSUES IN MENTAL HEALTH NURSING
LA English
DT Article
ID PHYSICAL HEALTH; MENTAL-ILLNESS; METABOLIC SYNDROME; SCHIZOPHRENIA;
   WEIGHT; CARE; SATISFACTION; OUTPATIENTS; EXERCISE; PEOPLE
AB The purpose of this study is to explore prerequisites for a healthy lifestyle as described by individuals diagnosed with psychosis. Forty participants who had performed a lifestyle intervention focusing on physical activities and lifestyle education were interviewed. Conventional content analysis was used. The results are described in two categories: (1) Individual Prerequisites and (2) Being a Part of Society. The individuals said that they got stuck in a state of planning without taking action. It was pointless to make a bigger effort because the psychotic disorder could, at any time, worsen the prerequisites. They also said that they wanted to live like everybody else and therefore tried to adopt a normal lifestyle. Future interventions or professional support by mental health nurses and other health care givers should target the transition from planning to action to achieve a healthy lifestyle, and should help the individual to taking part in society.
C1 [Wardig, Rikard Erik; Bachrach-Lindstrom, Margareta; Foldemo, Anniqa; Lindstrom, Torbjorn] Linkoping Univ, Linkoping, Sweden.
   [Hultsjo, Sally] Ryhov Cty Hosp, Psychiat Clin, Jonkoping, Sweden.
C3 Linkoping University
RP Wärdig, RE (corresponding author), Linkoping Univ, Dept Med & Hlth Sci, Linkoping, Sweden.
EM rikard.wardig@liu.se
OI Foldemo, Anniqa/0000-0003-4311-0739
CR Aki H, 2008, PSYCHIAT RES, V158, P19, DOI 10.1016/j.psychres.2006.05.017
   [Anonymous], 2004, CONTENT ANAL INTRO I
   [Anonymous], 2004, Nordic Nutrition Recommendations: Integrating nutrition and physical activity
   [Anonymous], 2002, Qualitative research & evaluation methods
   [Anonymous], PRIMARY HLTH CARE RE
   [Anonymous], 2006, PREVENTING CHRONIC D
   [Anonymous], 2010, International statistical classification of diseases and related health problems - 10th revision
   Blythe J, 2012, INT J MENT HEALTH NU, V21, P193, DOI 10.1111/j.1447-0349.2011.00792.x
   Brar JS, 2005, J CLIN PSYCHIAT, V66, P205, DOI 10.4088/JCP.v66n0208
   Brunero S, 2010, INT J NURS STUD, V47, P753, DOI 10.1016/j.ijnurstu.2009.11.004
   Buckley PF, 2008, J CLIN PSYCHIAT, V69, P4
   Buhagiar K, 2011, BMC PSYCHIATRY, V11, DOI 10.1186/1471-244X-11-104
   Choi KH, 2012, SCHIZOPHR RES, V139, P73, DOI 10.1016/j.schres.2012.05.001
   Navarro MD, 2013, CLIN ENDOCRINOL, V78, P681, DOI 10.1111/cen.12051
   Dodd KJ, 2011, DISABIL REHABIL, V33, P1222, DOI 10.3109/09638288.2010.526162
   Edmondson M, 2012, SCHIZOPHR RES, V139, P110, DOI 10.1016/j.schres.2012.04.014
   Edward KL, 2010, ARCH PSYCHIAT NURS, V24, P46, DOI 10.1016/j.apnu.2009.04.009
   Foldemo A, 2004, SOC PSYCH PSYCH EPID, V39, P381, DOI 10.1007/s00127-004-0750-8
   Foley DL, 2011, ARCH GEN PSYCHIAT, V68, P609, DOI 10.1001/archgenpsychiatry.2011.2
   Gibson M, 2011, INT J PSYCHIAT MED, V41, P127, DOI 10.2190/PM.41.2.c
   Gray R, 2012, INT J MENT HEALTH NU, V21, P191, DOI 10.1111/j.1447-0349.2012.00832.x
   Happell B, 2011, J PSYCHIATR MENT HLT, V18, P706, DOI 10.1111/j.1365-2850.2010.01666.x
   Hardy S, 2012, INT J MENT HEALTH NU, V21, P289, DOI 10.1111/j.1447-0349.2012.00823.x
   Hemingway H, 1997, AM J PUBLIC HEALTH, V87, P1484, DOI 10.2105/AJPH.87.9.1484
   Hsieh HF, 2005, QUAL HEALTH RES, V15, P1277, DOI 10.1177/1049732305276687
   Hultsjö S, 2012, INT J MENT HEALTH NU, V21, P480, DOI 10.1111/j.1447-0349.2012.00820.x
   International Diabetes Federation, 2011, UN FOR DIAB
   Joiner TE, 2005, ANNU REV PSYCHOL, V56, P287, DOI 10.1146/annurev.psych.56.091103.070320
   Kilbourne AM, 2006, INT J PSYCHIAT MED, V36, P383, DOI 10.2190/04XR-3107-4004-4670
   Knöchel C, 2012, PROG NEUROBIOL, V96, P46, DOI 10.1016/j.pneurobio.2011.11.007
   Kondracki NL, 2002, J NUTR EDUC BEHAV, V34, P224, DOI 10.1016/S1499-4046(06)60097-3
   Lysaker PH, 2004, SCHIZOPHR RES, V70, P277, DOI 10.1016/j.schres.2004.01.007
   McEvoy JP, 2005, SCHIZOPHR RES, V80, P19, DOI 10.1016/j.schres.2005.07.014
   McLellan E., 2003, Field Methods, V15, P63, DOI [10.1177/1525822X02239573, DOI 10.1177/1525822X02239573]
   Meyer JM, 2009, ACTA PSYCHIAT SCAND, V119, P4, DOI 10.1111/j.1600-0447.2008.01317.x
   Newcomer JW, 2006, J CLIN PSYCHIAT, V67, P25, DOI 10.4088/JCP.1106e16
   Orbell S, 1998, BRIT J SOC PSYCHOL, V37, P151, DOI 10.1111/j.2044-8309.1998.tb01162.x
   Palik E, 2005, DIABETES RES CLIN PR, V68, pS60, DOI 10.1016/j.diabres.2005.03.008
   Porsdal V, 2010, BMC PSYCHIATRY, V10, DOI 10.1186/1471-244X-10-42
   Riegel B, 2012, ADV NURS SCI, V35, P194, DOI 10.1097/ANS.0b013e318261b1ba
   Roberts SH, 2011, J ADV NURS, V67, P690, DOI 10.1111/j.1365-2648.2010.05546.x
   Schmutte T, 2009, PSYCHIAT QUART, V80, P1, DOI 10.1007/s11126-008-9088-9
   Schultz SH, 2007, AM FAM PHYSICIAN, V75, P1821
   Scott David, 2011, Issues Ment Health Nurs, V32, P589, DOI 10.3109/01612840.2011.569846
   Sheeran P., 2002, EUR REV SOC PSYCHOL, V12, P1, DOI [10.1080/14792772143000003, DOI 10.1080/14792772143000003]
   Sniehotta FF, 2005, EUR J SOC PSYCHOL, V35, P565, DOI 10.1002/ejsp.258
   Strassnig M, 2003, SCHIZOPHRENIA BULL, V29, P393, DOI 10.1093/oxfordjournals.schbul.a007013
   Vandyk AD, 2012, INT J MENT HEALTH NU, V21, P349, DOI 10.1111/j.1447-0349.2011.00790.x
   Viertiö S, 2012, EUR PSYCHIAT, V27, P409, DOI 10.1016/j.eurpsy.2010.12.005
   World Health Organization, 1998, HLTH PROM GLOSS
   Wright ER, 2000, J HEALTH SOC BEHAV, V41, P68, DOI 10.2307/2676361
NR 51
TC 17
Z9 18
U1 0
U2 4
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0161-2840
EI 1096-4673
J9 ISSUES MENT HEALTH N
JI Issues Ment. Health Nurs.
PD AUG
PY 2013
VL 34
IS 8
BP 602
EP 610
DI 10.3109/01612840.2013.790525
PG 9
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA V38TV
UT WOS:000209366600006
PM 23909672
DA 2025-06-11
ER

PT J
AU Prakash, P
   Khanna, V
   Singh, V
   Jyoti, A
   Jain, M
   Keshari, RS
   Barthwal, MK
   Dikshit, M
AF Prakash, Prem
   Khanna, Vivek
   Singh, Vishal
   Jyoti, Anupam
   Jain, Manish
   Keshari, Ravi Shankar
   Barthwal, Manoj Kumar
   Dikshit, Madhu
TI Atorvastatin Protects against Ischemia-Reperfusion Injury in
   Fructose-Induced Insulin Resistant Rats
SO CARDIOVASCULAR DRUGS AND THERAPY
LA English
DT Article
DE High fructose diet; Insulin Resistance Syndrome; Endothelial
   Dysfunction; Myocardial Ischemia-Reperfusion Injury; Atorvastatin;
   Akt/Nitric Oxide Synthase (NOS)
ID NITRIC-OXIDE SYNTHASE; PRIOR MYOCARDIAL-INFARCTION; AORTIC
   ENDOTHELIAL-CELLS; CORONARY-HEART-DISEASE; ISCHEMIA/REPERFUSION INJURY;
   CARDIOVASCULAR-DISEASES; REDUCTASE INHIBITORS; MEDIATED RELAXATION;
   ANOXIC TISSUES; EXPRESSION
AB High fructose (HFr) intake is known to cause insulin resistance syndrome (IRS), however its effect against acute coronary events remains elusive. The present study was undertaken to evaluate the effect of HFr (60%) diet on myocardial ischemia-reperfusion (MI-RP) injury and its modulation by atorvastatin treatment.
   Wistar rats kept on HFr/chow feeding for 10 weeks, received atorvastatin (30 mg/kg, per oral) or vehicle for two additional weeks followed by MI-RP injury.
   MI-RP injury was significantly augmented in HFr fed rats, as evident by the increase in infarct size (IS, 65 +/- 5% vs. 43 +/- 7%) and activities of cardiac injury biomarkers [serum lactate dehydrogenase (LDH, 698 +/- 57 vs. 444 +/- 26 U/L), creatinine kinase (CK-MB, 584 +/- 58 vs. 435 +/- 28 U/L) and tissue myeloperoxidase (MPO, 235 +/- 15 vs. 101 +/- 11 mu M/min/100 mg tissue)]. Insulin resistance (plasma glucose, 64 +/- 5 vs. 100 +/- 5 mg/dl; AUC (0-120 min), p < 0.05), MI-RP injury (IS 20 +/- 5%, LDH 292 +/- 28 U/L, CK-MB 257 +/- 13 U/L, MPO 95 +/- 5 mu M/min/100 mg tissue) and triglyceride (TG) level were significantly reduced, while myocardial Akt, p-Akt, eNOS, p-eNOS and iNOS protein expression were significantly enhanced following atorvastatin treatment in comparison to HFr fed rats. Oxidative stress marker, malondialdehyde and circulating levels of inflammatory cytokines (CRP, IL-6, IFN-gamma and TNF) were significantly reduced, while total nitrite content in the tissue and plasma was significantly augmented in atorvastatin treated rats. Atorvastatin also ameliorated endothelial dysfunction and significantly enhanced aortic Akt and eNOS protein expression.
   Atorvastatin conferred significant protection against MI-RP injury and alleviated HFr induced IRS possibly by increasing NOS expression through Akt dependent pathway.
C1 [Prakash, Prem; Khanna, Vivek; Singh, Vishal; Jyoti, Anupam; Jain, Manish; Keshari, Ravi Shankar; Barthwal, Manoj Kumar; Dikshit, Madhu] CSIR Cent Drug Res Inst, Div Pharmacol, Lucknow 226001, Uttar Pradesh, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Central Drug Research Institute (CDRI)
RP Dikshit, M (corresponding author), CSIR Cent Drug Res Inst, Div Pharmacol, 1 MG Marg, Lucknow 226001, Uttar Pradesh, India.
EM madhu_dikshit@cdri.res.in
RI Singh, Vishal/N-1838-2019; Prakash, Prem/AAI-1672-2020; Jain,
   Manish/ABE-7652-2021
OI Jyoti, Anupam/0000-0002-4135-7466; Jain, Manish/0000-0002-7263-9829;
   Khanna, Vivek/0000-0003-0541-5355; Prakash, Prem/0000-0001-9501-0065;
   Singh, Vishal/0000-0003-3577-1713
FU Central Drug Research Institute (CDRI); Council of Scientific and
   Industrial Research (CSIR), Government of India [NWP0034]; DBT-INDIGO
   project; Council of Scientific and Industrial Research (CSIR); Indian
   Council of Medical Research (ICMR), India
FX This work was supported by Central Drug Research Institute (CDRI),
   Council of Scientific and Industrial Research (CSIR), Government of
   India [NWP0034] and DBT-INDIGO project. We gratefully acknowledge the
   award of research fellowships by the Council of Scientific and
   Industrial Research (CSIR) and Indian Council of Medical Research
   (ICMR), India.
CR Atar S, 2006, AM J PHYSIOL-HEART C, V290, pH1960, DOI 10.1152/ajpheart.01137.2005
   Awasthi H, 2010, LIFE SCI, V86, P87, DOI 10.1016/j.lfs.2009.11.007
   Bell RM, 2003, J AM COLL CARDIOL, V41, P508, DOI 10.1016/S0735-1097(02)02816-4
   Bell RM, 2001, CARDIOVASC RES, V52, P274, DOI 10.1016/S0008-6363(01)00394-7
   Bolli R, 2001, J MOL CELL CARDIOL, V33, P1897, DOI 10.1006/jmcc.2001.1462
   BOUCHARDTHOMASS.AA, 2010, AM J PHYSL HEAR 1022
   Bressler P, 1996, DIABETOLOGIA, V39, P1345, DOI 10.1007/s001250050581
   Cai L, 2002, DIABETES, V51, P1938, DOI 10.2337/diabetes.51.6.1938
   Calvert JW, 2009, CARDIOVASC RES, V83, P195, DOI 10.1093/cvr/cvp079
   Ceriello A, 2002, DIABETES, V51, P1076, DOI 10.2337/diabetes.51.4.1076
   Cersosimo E, 2006, DIABETES-METAB RES, V22, P423, DOI 10.1002/dmrr.634
   Chess DJ, 2007, AM J PHYSIOL-HEART C, V293, pH1853, DOI 10.1152/ajpheart.00544.2007
   Cho E, 2002, J AM COLL CARDIOL, V40, P954, DOI 10.1016/S0735-1097(02)02044-2
   Cleland SJ, 2000, CLIN SCI, V98, P531, DOI 10.1042/CS20000013
   Colado MI, 1997, BRIT J PHARMACOL, V121, P827, DOI 10.1038/sj.bjp.0701201
   Das M, 2003, J PHYSIOL-LONDON, V547, P893, DOI 10.1113/jphysiol.2002.035006
   Di Napoli P, 2005, CARDIOVASC RES, V66, P462, DOI 10.1016/j.cardiores.2005.02.008
   Dimmeler S, 1999, NATURE, V399, P601, DOI 10.1038/21224
   Gao F, 2002, CIRCULATION, V105, P1497, DOI 10.1161/01.CIR.0000012529.00367.0F
   Giustarini D, 2008, METHOD ENZYMOL, V440, P361, DOI 10.1016/S0076-6879(07)00823-3
   Graff G, 1998, J PHARMACOL TOXICOL, V39, P169, DOI 10.1016/S1056-8719(98)00023-9
   Haffner SM, 1998, NEW ENGL J MED, V339, P229, DOI 10.1056/NEJM199807233390404
   Hanley PJ, 2003, J PHYSIOL-LONDON, V547, P387, DOI 10.1113/jphysiol.2002.037044
   Hausenloy DJ, 2004, CARDIOVASC RES, V61, P448, DOI 10.1016/j.cardiores.2003.09.024
   Higashi Y, 2009, CIRC J, V73, P411, DOI 10.1253/circj.CJ-08-1102
   HWANG IS, 1987, HYPERTENSION, V10, P512, DOI 10.1161/01.HYP.10.5.512
   Johnson RJ, 2009, ENDOCR REV, V30, P96, DOI 10.1210/er.2008-0033
   Jordan JE, 2003, J PHARMACOL EXP THER, V307, P1007, DOI 10.1124/jpet.103.055970
   Kim F, 2001, AM J PHYSIOL-CELL PH, V280, pC1057, DOI 10.1152/ajpcell.2001.280.5.C1057
   Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213
   Kolyada AY, 2001, HYPERTENSION, V38, P1024, DOI 10.1161/hy1101.093103
   Laufs U, 1998, CIRCULATION, V97, P1129, DOI 10.1161/01.CIR.97.12.1129
   Li HT, 2003, BIOCHEMISTRY-US, V42, P1150, DOI 10.1021/bi026385a
   Li HT, 2001, J BIOL CHEM, V276, P24482, DOI 10.1074/jbc.M011648200
   Marfella R, 2002, DIABETOLOGIA, V45, P1172, DOI 10.1007/s00125-002-0882-x
   McGillicuddy FC, 2009, J BIOL CHEM, V284, P31936, DOI 10.1074/jbc.M109.061655
   Miller A, 2008, CURR OPIN GASTROEN, V24, P204, DOI 10.1097/MOG.0b013e3282f3f4c4
   Miller AW, 1999, J VASC RES, V36, P385, DOI 10.1159/000025678
   Miller AW, 2004, AM J PHYSIOL-REG I, V287, pR157, DOI 10.1152/ajpregu.00647.2003
   Morel S, 2005, MOL CELL BIOCHEM, V272, P9, DOI 10.1007/s11010-005-4778-1
   Morel S, 2003, CLIN EXP PHARMACOL P, V30, P446, DOI 10.1046/j.1440-1681.2003.03858.x
   Nagai Y, 2009, CELL METAB, V9, P252, DOI 10.1016/j.cmet.2009.01.011
   Nakaya Y, 2000, AM J CLIN NUTR, V71, P54
   PANCHAL S, 2010, J CARDIOVASC PH 1014
   Penumathsa SV, 2007, J MOL CELL CARDIOL, V42, P508, DOI 10.1016/j.yjmcc.2006.10.018
   Prakash P, 2011, THROMB RES, V127, P111, DOI 10.1016/j.thromres.2010.11.007
   Raghavan SAV, 2001, EUR J PHARMACOL, V431, P61, DOI 10.1016/S0014-2999(01)01407-8
   Rajamani U, 2010, AM J PHYSIOL-CELL PH, V299, pC139, DOI 10.1152/ajpcell.00020.2010
   Reaven GM, 2003, J CLIN ENDOCR METAB, V88, P2399, DOI 10.1210/jc.2003-030087
   Roberts CK, 2003, J APPL PHYSIOL, V94, P941, DOI 10.1152/japplphysiol.00536.2002
   Roberts CK, 2002, ATHEROSCLEROSIS, V163, P321, DOI 10.1016/S0021-9150(02)00010-2
   Rodríguez-Calvo R, 2009, HEPATOLOGY, V49, P106, DOI 10.1002/hep.22570
   Rosanio S, 2006, CARDIOVASC DRUG THER, V20, P27, DOI 10.1007/s10557-005-5203-4
   Rotter V, 2003, J BIOL CHEM, V278, P45777, DOI 10.1074/jbc.M301977200
   Shiva S, 2007, J EXP MED, V204, P2089, DOI 10.1084/jem.20070198
   SINGH V, 2011, J PHYSL BIOCH   0201
   Stranahan AM, 2008, HIPPOCAMPUS, V18, P1085, DOI 10.1002/hipo.20470
   THORBURN AW, 1989, AM J CLIN NUTR, V49, P1155, DOI 10.1093/ajcn/49.6.1155
   Tran LT, 2009, MOL CELL BIOCHEM, V332, P145, DOI 10.1007/s11010-009-0184-4
   Venugopal SK, 2002, CIRCULATION, V106, P1439, DOI 10.1161/01.CIR.0000033116.22237.F9
   Ye YM, 2006, AM J PHYSIOL-HEART C, V291, pH1158, DOI 10.1152/ajpheart.00096.2006
   Yellon DM, 2007, NEW ENGL J MED, V357, P1121, DOI 10.1056/NEJMra071667
   ZAVARONI I, 1980, METABOLISM, V29, P970, DOI 10.1016/0026-0495(80)90041-4
   Zhao CX, 2009, J PHARMACOL EXP THER, V328, P610, DOI 10.1124/jpet.108.143396
NR 64
TC 23
Z9 27
U1 0
U2 4
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0920-3206
J9 CARDIOVASC DRUG THER
JI Cardiovasc. Drugs Ther.
PD AUG
PY 2011
VL 25
IS 4
BP 285
EP 297
DI 10.1007/s10557-011-6312-x
PG 13
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 804DN
UT WOS:000293634500003
PM 21671014
DA 2025-06-11
ER

PT J
AU Mastrocola, R
   Aragno, M
   Alloatti, G
   Collino, M
   Penna, C
   Pagliaro, P
AF Mastrocola, Raffaella
   Aragno, Manuela
   Alloatti, Giuseppe
   Collino, Massimo
   Penna, Claudia
   Pagliaro, Pasquale
TI Metaflammation: Tissue-Specific Alterations of the NLRP3 Inflammasome
   Platform in Metabolic Syndrome
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Metabolic syndrome; metaflammation; NLRP3 inflammasome; oxidative
   stress; aging; myocardial ischemia/reperfusion; steatohepatitis; chronic
   kidney disease
ID NONALCOHOLIC FATTY LIVER; GLYCATION END-PRODUCTS;
   MYOCARDIAL-ISCHEMIA-REPERFUSION; RECEPTOR PROTEIN-3 INFLAMMASOME;
   THIOREDOXIN-INTERACTING PROTEIN; CHRONIC KIDNEY-DISEASE; DIET-INDUCED
   OBESITY; NF-KAPPA-B; INSULIN-RESISTANCE; DIABETIC-NEPHROPATHY
AB In the last decades, the extension of life expectancy and the increased consumption of foods rich in saturated fats and added sugars have exposed the general population to emerging health problems.
   The prevalence of metabolic syndrome (MS), composed of a cluster of factors as obesity, dyslipidemia, hyperglycemia, and hypertension, is rapidly increasing in industrialized and developing countries leading to precocious onset of age-related diseases. Indeed, oxidative stress, accumulation of advanced glycation endproducts, and a chronic low-grade inflammation are common features of MS and physiological ageing. In particular, the entire set of MS factors contributes to the development of an inflammatory status named metaflammation, which has been associated with activation of early innate immune response through the as sembling of the multiprotein complex inflammasome. The most investigated family of inflammasome platforms is the NOD-like receptor pyridine containing (NLRP) 3, which is activated by several exogenous and endogenous stimuli, leading to the sequential cleavage of caspase-1 and IL-1 beta, followed by secretion of active IL-1 beta. We here collect the most recent findings on NLRP3 activation in MS providing evidence of its central role in disease progression and organ dysfunction in target tissues of metaflammation, in particular in cardiovascular, hepatic and renal complications, with a focus on oxidative stress and advanced glycation endproducts. A wide overview of the most promising strategies for the modulation of NLRP3 activation and related metabolic repercussions is also provided, since the finding of specific pharmacological tools is an urgent requirement to reduce the social and economic burden of MS- and elderly-associated diseases.
C1 [Mastrocola, Raffaella; Aragno, Manuela; Penna, Claudia; Pagliaro, Pasquale] Univ Turin, Dept Clin & Biol Sci, Turin, Italy.
   [Alloatti, Giuseppe] Univ Turin, Dept Life Sci & Syst Biol, Turin, Italy.
   [Collino, Massimo] Univ Turin, Dept Drug Sci & Technol, Via P Giuria 9, I-10125 Turin, Italy.
C3 University of Turin; University of Turin; University of Turin
RP Collino, M (corresponding author), Univ Turin, Dept Drug Sci & Technol, Via P Giuria 9, I-10125 Turin, Italy.
EM massimo.collino@unit.it
RI Penna, Claudia/J-5103-2018; Collino, Massimo/AAK-8532-2020; Pagliaro,
   Pasquale/E-5239-2010
OI ARAGNO, Manuela/0000-0002-0453-5235; Pagliaro,
   Pasquale/0000-0002-4386-1383
CR Abe J, 2013, CIRCULATION, V128, P579, DOI 10.1161/CIRCULATIONAHA.113.004390
   Ahima RS, 2009, NAT MED, V15, P996, DOI 10.1038/nm0909-996
   Bakala H, 2013, BBA-MOL BASIS DIS, V1832, P2057, DOI 10.1016/j.bbadis.2013.07.015
   Bakker PJ, 2014, KIDNEY INT, V85, P1112, DOI 10.1038/ki.2013.503
   Barja G, 2014, PROG MOL BIOL TRANSL, V127, P1, DOI 10.1016/B978-0-12-394625-6.00001-5
   Bauernfeind F, 2011, J IMMUNOL, V187, P613, DOI 10.4049/jimmunol.1100613
   Benetti E, 2016, J PHARMACOL EXP THER, V359, P45, DOI 10.1124/jpet.116.235069
   Birnbaum Y, 2016, BMJ OPEN DIAB RES CA, V4, DOI 10.1136/bmjdrc-2016-000227
   Boini KM, 2016, ONCOTARGET, V7, P19031, DOI 10.18632/oncotarget.8023
   Bonomini F, 2015, AGING DIS, V6, P109, DOI 10.14336/AD.2014.0305
   Cai WJ, 2014, P NATL ACAD SCI USA, V111, P4940, DOI 10.1073/pnas.1316013111
   Campbell M, 2013, J MOL MED, V91, P1059, DOI 10.1007/s00109-013-1050-0
   Charrière G, 2003, J BIOL CHEM, V278, P9850, DOI 10.1074/jbc.M210811200
   Chen GY, 2010, NAT REV IMMUNOL, V10, P826, DOI 10.1038/nri2873
   Chen Z, 2014, CURR OPIN LIPIDOL, V25, P339, DOI 10.1097/MOL.0000000000000107
   Chiazza F, 2015, MOL MED, V21, P1025, DOI 10.2119/molmed.2015.00104
   Collino M, 2013, BIOCHEM PHARMACOL, V85, P257, DOI 10.1016/j.bcp.2012.10.014
   Compan V, 2012, IMMUNITY, V37, P487, DOI 10.1016/j.immuni.2012.06.013
   Coughlan MT, 2009, J AM SOC NEPHROL, V20, P742, DOI 10.1681/ASN.2008050514
   Csak T, 2014, LIVER INT, V34, P1402, DOI 10.1111/liv.12537
   Csak T, 2011, HEPATOLOGY, V54, P133, DOI 10.1002/hep.24341
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Drouin-Ouellet J, 2012, TRENDS PHARMACOL SCI, V33, P542, DOI 10.1016/j.tips.2012.07.002
   DYER DG, 1993, J CLIN INVEST, V91, P2463, DOI 10.1172/JCI116481
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Fakhouri Tala H I, 2012, NCHS Data Brief, P1
   Feldman N, 2015, AGEING RES REV, V24, P29, DOI 10.1016/j.arr.2015.01.003
   Femminò S, 2015, VASC PHARMACOL, V75, P51, DOI 10.1016/j.vph.2015.11.030
   Fernández-Garcia JC, 2013, CURR VASC PHARMACOL, V11, P906, DOI 10.2174/15701611113116660175
   Gaens KHJ, 2014, ARTERIOSCL THROM VAS, V34, P1199, DOI 10.1161/ATVBAHA.113.302281
   Gao P, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/504761
   Geoffroy K, 2004, J BIOL CHEM, V279, P34343, DOI 10.1074/jbc.M403273200
   Ghosh AR, 2016, DIABETES, V65, P3440, DOI 10.2337/db16-0331
   Gong YN, 2010, CELL RES, V20, P1289, DOI 10.1038/cr.2010.135
   He Q, 2012, ASIAN PAC J CANCER P, V13, P1365, DOI 10.7314/APJCP.2012.13.4.1365
   Hermansson C, 2013, BIOCHEM BIOPH RES CO, V430, P425, DOI 10.1016/j.bbrc.2012.11.070
   Hornung V, 2008, NAT IMMUNOL, V9, P847, DOI 10.1038/ni.1631
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Hu SD, 2013, TOHOKU J EXP MED, V230, P25, DOI 10.1620/tjem.230.25
   Iacobini C, 2009, J PATHOL, V218, P360, DOI 10.1002/path.2536
   Jeftic I, 2015, MOL MED, V21, P453, DOI 10.2119/molmed.2014.00178
   Jiang T, 2005, J BIOL CHEM, V280, P32317, DOI 10.1074/jbc.M500801200
   Jong WMC, 2014, INT J CARDIOL, V177, P41, DOI 10.1016/j.ijcard.2014.09.148
   Jura M, 2016, AGE, V38, DOI 10.1007/s11357-016-9884-3
   Kang R, 2016, J IMMUNOL, V196, P4331, DOI 10.4049/jimmunol.1502340
   Kawaguchi M, 2011, CIRCULATION, V123, P594, DOI 10.1161/CIRCULATIONAHA.110.982777
   Kim SM, 2015, AM J PHYSIOL-RENAL, V308, pF993, DOI 10.1152/ajprenal.00637.2014
   Kurek K, 2014, LIVER INT, V34, P1074, DOI 10.1111/liv.12331
   Kurella M, 2005, J AM SOC NEPHROL, V16, P2134, DOI 10.1681/ASN.2005010106
   Lee BC, 2014, BBA-MOL BASIS DIS, V1842, P446, DOI 10.1016/j.bbadis.2013.05.017
   Lee HJ, 2015, WORLD J GASTROENTERO, V21, P12787, DOI 10.3748/wjg.v21.i45.12787
   Li Y, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057130
   Lipinski MJ, 2014, J CARDIOVASC PHARM, V63, P314, DOI 10.1097/FJC.0000000000000070
   Liu Y, 2014, BASIC RES CARDIOL, V109, DOI 10.1007/s00395-014-0415-z
   Ma CH, 2015, J ETHNOPHARMACOL, V172, P108, DOI 10.1016/j.jep.2015.06.015
   Maessen DE, 2016, DIABETES, V65, P956, DOI 10.2337/db15-1390
   Mahady SE, 2012, CLIN LIVER DIS, V16, P631, DOI 10.1016/j.cld.2012.05.003
   Marchesini G, 2003, HEPATOLOGY, V37, P917, DOI 10.1053/jhep.2003.50161
   Marchetti C, 2014, J CARDIOVASC PHARM, V63, P316, DOI 10.1097/FJC.0000000000000053
   Martín-Sánchez F, 2016, CELL DEATH DIFFER, V23, P1219, DOI 10.1038/cdd.2015.176
   Martinon F, 2002, MOL CELL, V10, P417, DOI 10.1016/S1097-2765(02)00599-3
   Mastrocola R, 2016, FREE RADICAL BIO MED, V91, P224, DOI 10.1016/j.freeradbiomed.2015.12.022
   Mastrocola R, 2016, Cell Longev, V2016, P1, DOI [DOI 10.1155/2016/3480637, 10.1155/2016/3480637]
   Mastrocola R., 2016, OXID MED CELL LONGEV, DOI DOI 10.1155/2016/5271251
   Mastrocola R, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0119587
   Mastrocola R, 2013, AM J PHYSIOL-GASTR L, V305, pG398, DOI 10.1152/ajpgi.00450.2012
   McRae S, 2016, J BIOL CHEM, V291, P3254, DOI 10.1074/jbc.M115.694059
   Mezzaroma E, 2011, P NATL ACAD SCI USA, V108, P19725, DOI 10.1073/pnas.1108586108
   Nakamura A, 2005, DIABETES CARE, V28, P2890, DOI 10.2337/diacare.28.12.2890
   Nigro D, 2017, J NUTR BIOCHEM, V42, P160, DOI 10.1016/j.jnutbio.2017.01.010
   Ozaki E, 2015, J INFLAMM RES, V8, P15, DOI 10.2147/JIR.S51250
   Patel MN, 2015, P NATL ACAD SCI USA, V112, P506, DOI 10.1073/pnas.1414536112
   Pejnovic NN, 2013, DIABETES, V62, P1932, DOI 10.2337/db12-0222
   Pelegrin P, 2006, EMBO J, V25, P5071, DOI 10.1038/sj.emboj.7601378
   Petrilli V, 2007, CELL DEATH DIFFER, V14, P1583, DOI 10.1038/sj.cdd.4402195
   Pomerantz BJ, 2001, P NATL ACAD SCI USA, V98, P2871, DOI 10.1073/pnas.041611398
   Portincasa P, 2005, CLIN BIOCHEM, V38, P203, DOI 10.1016/j.clinbiochem.2004.10.014
   Rabadi MM, 2012, AM J PHYSIOL-RENAL, V302, pF730, DOI 10.1152/ajprenal.00520.2011
   Redon J, 2015, CURR HYPERTENS REP, V17, DOI 10.1007/s11906-015-0555-z
   Reynaert N. L., 2016, INT J BIOCHEM CELL B, P51357
   Ribeiro Filho Fernando F., 2006, Arq Bras Endocrinol Metab, V50, P230, DOI 10.1590/S0004-27302006000200009
   Rydén L, 2014, DIABETES VASC DIS RE, V11, P133, DOI 10.1177/1479164114525548
   Salminen A, 2012, CELL MOL LIFE SCI, V69, P2999, DOI 10.1007/s00018-012-0962-0
   Samra YA, 2016, LIFE SCI, V157, P187, DOI 10.1016/j.lfs.2016.06.002
   Sandanger O, 2016, BIOCHEM BIOPH RES CO, V469, P1012, DOI 10.1016/j.bbrc.2015.12.051
   Sandanger O, 2013, CARDIOVASC RES, V99, P164, DOI 10.1093/cvr/cvt091
   Sanyal AJ, 2001, GASTROENTEROLOGY, V120, P1183, DOI 10.1053/gast.2001.23256
   Schroder K, 2010, SCIENCE, V327, P296, DOI 10.1126/science.1184003
   Shahzad K, 2015, KIDNEY INT, V87, P74, DOI 10.1038/ki.2014.271
   Shaw AC, 2013, NAT REV IMMUNOL, V13, P875, DOI 10.1038/nri3547
   Signorelli P, 2005, J NUTR BIOCHEM, V16, P449, DOI 10.1016/j.jnutbio.2005.01.017
   Solini A, 2013, J PATHOL, V231, P342, DOI 10.1002/path.4237
   Steinberg GR, 2014, IMMUNOL CELL BIOL, V92, P340, DOI 10.1038/icb.2014.11
   Sui YH, 2016, WORLD J GASTROENTERO, V22, P2533, DOI 10.3748/wjg.v22.i8.2533
   Summers SA, 2006, PROG LIPID RES, V45, P42, DOI 10.1016/j.plipres.2005.11.002
   Sutterwala FS, 2014, ANN NY ACAD SCI, V1319, P82, DOI 10.1111/nyas.12458
   Szkudelski T, 2011, ANN NY ACAD SCI, V1215, P34, DOI 10.1111/j.1749-6632.2010.05844.x
   Takahashi M, 2011, TRENDS CARDIOVAS MED, V21, P37, DOI 10.1016/j.tcm.2012.02.002
   Takeuchi O, 2010, CELL, V140, P805, DOI 10.1016/j.cell.2010.01.022
   Tan CYR, 2015, NEPHRON, V129, P109, DOI 10.1159/000368238
   Tang B, 2015, INT J CARDIOL, V180, P134, DOI 10.1016/j.ijcard.2014.11.161
   Thomsen M, 2014, JAMA INTERN MED, V174, P15, DOI 10.1001/jamainternmed.2013.10522
   Tian JJ, 2016, FASEB J, V30, P4202, DOI 10.1096/fj.201600392RR
   Tilg H, 2010, HEPATOLOGY, V52, P1836, DOI 10.1002/hep.24001
   Toldo S, 2016, INT J CARDIOL, V209, P215, DOI 10.1016/j.ijcard.2016.02.043
   Toldo S, 2016, BIOCHEM BIOPH RES CO, V470, P811, DOI 10.1016/j.bbrc.2016.01.088
   Toldo S, 2015, CARDIOVASC RES, V105, P203, DOI 10.1093/cvr/cvu259
   Turner CM, 2014, BMC NEPHROL, V15, DOI 10.1186/1471-2369-15-21
   Van Gaal LF, 2006, NATURE, V444, P875, DOI 10.1038/nature05487
   van Hout GPJ, 2017, EUR HEART J, V38, P828, DOI 10.1093/eurheartj/ehw247
   Vandanmagsar B, 2011, NAT MED, V17, P179, DOI 10.1038/nm.2279
   Wan XY, 2016, CAN J GASTROENTEROL, V2016, DOI 10.1155/2016/6489012
   Wang W, 2015, FREE RADICAL BIO MED, V83, P214, DOI 10.1016/j.freeradbiomed.2015.02.029
   Wang W, 2013, BRIT J PHARMACOL, V169, P1352, DOI 10.1111/bph.12226
   Wang Y, 2006, J LIPID RES, V47, P2028, DOI 10.1194/jlr.M600177-JLR200
   Ward JR, 2010, J BIOL CHEM, V285, P23145, DOI 10.1074/jbc.M109.072793
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Wree A, 2014, J MOL MED, V92, P1069, DOI 10.1007/s00109-014-1170-1
   Wu JM, 2011, AM J CARDIOVASC DIS, V1, P38
   Yang G, 2016, SCI REP-UK, V6, DOI 10.1038/srep24399
   Yang SJ, 2014, METABOLISM, V63, P693, DOI 10.1016/j.metabol.2014.02.003
   Zhou RB, 2011, NATURE, V469, P221, DOI 10.1038/nature09663
   Zoppini G, 2012, DIABETES CARE, V35, P99, DOI 10.2337/dc11-1346
   Zou X, 2014, ANTIOXID REDOX SIGN, V21, P1557, DOI 10.1089/ars.2013.5538
   Zuurbier CJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0040643
NR 125
TC 60
Z9 65
U1 0
U2 19
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2018
VL 25
IS 11
BP 1294
EP 1310
DI 10.2174/0929867324666170407123522
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA GD2OA
UT WOS:000430338500003
PM 28403789
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Kolinsky, NC
   Weare-Regales, N
   Lockey, RF
AF Kolinsky, Nicholas C.
   Weare-Regales, Natalia
   Lockey, Richard F.
TI A Practical Approach to Assist Asthmatics to Lose Weight
SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
LA English
DT Review
DE Asthma; Obesity; Weight loss; Diet; Exercise; Bariatric surgery; Weight
   gain; Weight loss medication
ID CLINICAL-PRACTICE GUIDELINES; BODY-MASS INDEX; BARIATRIC SURGERY;
   AMERICAN ASSOCIATION; LOSS MAINTENANCE; OBESITY; OVERWEIGHT;
   ENDOCRINOLOGISTS; INTERVENTION; EPIDEMIOLOGY
AB Treating patients with obesity, particularly asthmatics, is a complex challenge that requires a unique and individually tailored approach. Obesity, defined by the Centers for Disease Control and Prevention, is a body mass index of 30.0 kg/m(2) or greater. It affects approximately 43% of adults and 19% of youth in America. It is a multifactorial disease and should be managed with the same intensity as any other medical problem, for it represents a risk factor for the onset and severity of asthma. Furthermore, it is a comorbid condition that exacerbates rhinosinusitis, gastroesophageal reflux disease, obstructive sleep apnea, hypertension, anxiety, and depression. Being obese also increases morbidity for cardio/cerebrovascular diseases, metabolic syndrome, type 2 diabetes, breast and bladder cancer, and migraines. Osteoarthritis, in particular, of the knees and hips, is also associated with obesity, and that too will complicate asthma by hindering a subject's mobility and ability to exercise. This paper reviews the epidemiology and pathophysiology of obesity, its effect on asthma, and practical strategies to achieve weight loss. (C) 2021 American Academy of Allergy, Asthma & Immunology
C1 [Kolinsky, Nicholas C.; Lockey, Richard F.] Univ S Florida, Div Allergy & Immunol, Dept Internal Med, Morsani Coll Med, Tampa, FL 33620 USA.
   [Weare-Regales, Natalia] Univ S Florida, Div Endocrinol Diabet & Metab, Dept Internal Med, Morsani Coll Med, Tampa, FL 33620 USA.
C3 State University System of Florida; University of South Florida; State
   University System of Florida; University of South Florida
RP Kolinsky, NC (corresponding author), Univ S Florida, Morsani Coll Med, 13000 Bruce B Downs Blvd,Suite IIID, Tampa, FL 33612 USA.
EM nkolinsky@usf.edu
RI WeareRegales, Natalia/KWU-1222-2024
CR Akerman MJH, 2004, J ASTHMA, V41, P521, DOI 10.1081/JAS-120037651
   Amianto F, 2015, BMC PSYCHIATRY, V15, DOI 10.1186/s12888-015-0445-6
   [Anonymous], 2015, Obstet Gynecol, V126, pe112, DOI 10.1097/AOG.0000000000001211
   [Anonymous], 2020, Saxenda (liraglutide) injection, for subcutaneous use
   [Anonymous], 2020, CONTRAVE NALTREXONE
   [Anonymous], 2020, XENICAL ORLISTAT
   [Anonymous], 2020, AIDPEX P PHENTERMINE
   [Anonymous], 2020, QSYMIA PHENTERMINE T
   Anton SD, 2017, NUTRIENTS, V9, DOI 10.3390/nu9080822
   Asthma and Community Health Branch, 2019, TABL 3 1 CURR ASTHM TABL 3 1 CURR ASTHM
   Bent S, 2008, J GEN INTERN MED, V23, P854, DOI 10.1007/s11606-008-0632-y
   Berthon BS, 2015, CLIN EXP ALLERGY, V45, P908, DOI 10.1111/cea.12505
   Beuther DA, 2007, AM J RESP CRIT CARE, V175, P661, DOI 10.1164/rccm.200611-1717OC
   Biondi B, 2010, J CLIN ENDOCR METAB, V95, P3614, DOI 10.1210/jc.2010-1245
   Carnegie Christina, 2004, Rev Urol, V6 Suppl 6, pS3
   CCS Medical, 2012, DIAB NUTR PLAC FARM DIAB NUTR PLAC FARM
   Chaaban TA, 2019, EUR RESPIR REV, V28, DOI 10.1183/16000617.0003-2019
   Champagne CM, 2011, J AM DIET ASSOC, V111, P1826, DOI 10.1016/j.jada.2011.09.014
   Cheng J, 2016, ONCOTARGET, V7, P39216, DOI 10.18632/oncotarget.9581
   Cho YJ, 2016, PHYSIOLOGY, V31, P108, DOI 10.1152/physiol.00045.2015
   Cigna, 2020, PHARM BEN COV CRIT W PHARM BEN COV CRIT W
   Ciprandi G, 2011, INT J IMMUNOPATH PH, V24, P13, DOI 10.1177/03946320110240S403
   Clark JE, 2015, J DIABETES METAB DIS, V14, DOI 10.1186/s40200-015-0154-1
   da Luz FQ, 2018, NUTRIENTS, V10, DOI 10.3390/nu10070829
   Dare S, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0123579
   De Pergola G, 2013, J OBES, V2013, DOI 10.1155/2013/291546
   Dias SA, 2014, EUR RESPIR J, V43, P1368, DOI 10.1183/09031936.00053413
   Dixon AE, 2011, J ALLERGY CLIN IMMUN, V128, P508, DOI 10.1016/j.jaci.2011.06.009
   Drew BS, 2007, VASC HEALTH RISK MAN, V3, P817
   Dumesic DA, 2015, ENDOCR REV, V36, P487, DOI 10.1210/er.2015-1018
   Ferrara G, 2019, JMIR MHEALTH UHEALTH, V7, DOI 10.2196/mhealth.9232
   Ford ES, 2005, J ALLERGY CLIN IMMUN, V115, P897, DOI 10.1016/j.jaci.2004.11.050
   Foster-Schubert KE, 2012, OBESITY, V20, P1628, DOI 10.1038/oby.2011.76
   Frati F, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20010123
   Garvey WT, 2016, ENDOCR PRACT, V22, P1, DOI 10.4158/EP161365.GL
   Guilleminault L, 2017, NUTRIENTS, V9, DOI 10.3390/nu9111227
   Hall KD, 2018, MED CLIN N AM, V102, P183, DOI 10.1016/j.mcna.2017.08.012
   Han J, 2019, J ASTHMA, V56, P263, DOI 10.1080/02770903.2018.1455853
   Han YY, 2018, J ALLER CL IMM-PRACT, V6, P834, DOI 10.1016/j.jaip.2017.12.029
   Hasegawa K, 2015, J ALLERGY CLIN IMMUN, V136, P288, DOI 10.1016/j.jaci.2014.12.1931
   Institute of Medicine (US) Subcommittee on Military Weight Management, 2004, WEIGHT LOSS MAINT ST WEIGHT LOSS MAINT ST
   Ionut V, 2013, OBESITY, V21, P1093, DOI 10.1002/oby.20364
   Jaakkola JJK, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-48484-8
   Jackson Sylvia H, 2010, P T, V35, P498
   Johnson JB, 2007, FREE RADICAL BIO MED, V42, P665, DOI 10.1016/j.freeradbiomed.2006.12.005
   Kang JH, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000008632
   Kessler RC, 2013, BIOL PSYCHIAT, V73, P904, DOI 10.1016/j.biopsych.2012.11.020
   Kim KK, 2006, YONSEI MED J, V47, P614, DOI 10.3349/ymj.2006.47.5.614
   Knowler William C, 2002, N Engl J Med, V346, P393, DOI 10.1056/NEJMoa012512
   Kominiarek MA, 2017, AM J OBSTET GYNECOL, V217, P642, DOI 10.1016/j.ajog.2017.05.040
   Komiyama M, 2019, INTERNAL MED, V58, P317, DOI 10.2169/internalmedicine.1111-18
   Kozik AJ, 2019, ANN ALLERG ASTHMA IM, V122, P270, DOI 10.1016/j.anai.2018.12.005
   Lemstra M, 2016, PATIENT PREFER ADHER, V10, P1547, DOI 10.2147/PPA.S103649
   Lockey RF, 2014, ASTHMA COMORBIDITIES
   Mechanick JI, 2013, OBESITY, V21, pS1, DOI 10.1002/oby.20461
   Mehta A, 2017, OBES SCI PRACT, V3, P3, DOI 10.1002/osp4.84
   Melén E, 2010, J ALLERGY CLIN IMMUN, V126, P631, DOI 10.1016/j.jaci.2010.06.030
   Modave F, 2015, JMIR MHEALTH UHEALTH, V3, DOI 10.2196/mhealth.4669
   Montesi L, 2016, DIABET METAB SYND OB, V9, P37, DOI 10.2147/DMSO.S89836
   National Center for Biotechnology Information, 2020, PubChem Compound Summary for CID 86287518, Imidacloprid
   Nicklas JM, 2012, AM J PREV MED, V42, P481, DOI 10.1016/j.amepre.2012.01.005
   Nihalani N, 2011, J OBES, V2011, DOI 10.1155/2011/893629
   Nyenhuis SM, 2018, J ALLER CL IMM-PRACT, V6, P751, DOI 10.1016/j.jaip.2017.10.026
   Ostbye T, 2012, J WOMENS HEALTH, V21, P215, DOI 10.1089/jwh.2011.2947
   Domecq JP, 2015, J CLIN ENDOCR METAB, V100, P363, DOI 10.1210/jc.2014-3421
   Peacock K., 2020, MENOPAUSE STATPEARLS
   Peng YH, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000002911
   Persoskie A, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.170066
   Peters U, 2018, J ALLERGY CLIN IMMUN, V141, P1169, DOI 10.1016/j.jaci.2018.02.004
   Peters-Golden M, 2006, EUR RESPIR J, V27, P495, DOI 10.1183/09031936.06.00077205
   Pradeepan S, 2013, CURR ALLERGY ASTHM R, V13, P434, DOI 10.1007/s11882-013-0354-z
   Redman LM, 2011, ANTIOXID REDOX SIGN, V14, P275, DOI 10.1089/ars.2010.3253
   Rizk AK, 2012, ISRN PULMONOLOGY, V2012, P1
   Saltiel AR, 2017, J CLIN INVEST, V127, P1, DOI [10.1172/JCI92035, 10.1172/jci92035]
   Sandmeier R.H., 2000, Perm. J, V4, P26
   Serafino-Agrusa L, 2015, WORLD J CLIN CASES, V3, P285, DOI 10.12998/wjcc.v3.i3.285
   Sheehan MT, 2016, CLIN MED RES, V14, P83, DOI 10.3121/cmr.2016.1309
   Shin JH, 2013, DIABETES METAB SYNDR, V6, P131, DOI 10.2147/DMSO.S43403
   Shore SA, 2016, AM J RESP CELL MOL, V54, P609, DOI 10.1165/rcmb.2016-0052PS
   Stahl J.M., 2020, StatPearls
   Stanford FC, 2020, MENOPAUSE, V27, P1117, DOI 10.1097/GME.0000000000001589
   Steffen KJ, 2010, INT J EAT DISORDER, V43, P472, DOI 10.1002/eat.20829
   Stratakis CA, 2012, ENDOCRIN METAB CLIN, V41, P793, DOI 10.1016/j.ecl.2012.08.002
   Taylor B, 2008, THORAX, V63, P14, DOI 10.1136/thx.2007.082784
   Tchernof A, 2000, DIABETES METAB, V26, P12
   The Endocrine Society, 2019, SCI DAILY
   Türk Y, 2020, EUR RESPIR J, V56, DOI 10.1183/13993003.01820-2019
   U.S. Department of Health and Human Services and U.S. Department of Agriculture, 2015, APP 1 PHYS ACT GUID, V8th
   U.S. Department of Health and Human Services and U.S. Department of Agriculture, 2015, APP 2 EST CAL NEEDS APP 2 EST CAL NEEDS, V8th
   Van Gaal L, 2016, DIABETES CARE, V39, pS260, DOI 10.2337/dcS15-3016
   Vermeulen A, 1999, J CLIN ENDOCR METAB, V84, P3666, DOI 10.1210/jc.84.10.3666
   Wharton S, 2018, DIABET METAB SYND OB, V11, P427, DOI 10.2147/DMSO.S171365
   Wing RR, 2001, ANNU REV NUTR, V21, P323, DOI 10.1146/annurev.nutr.21.1.323
   Wolfe BM, 2016, CIRC RES, V118, P1844, DOI 10.1161/CIRCRESAHA.116.307591
   Wood LG, 2011, J ALLERGY CLIN IMMUN, V127, P1133, DOI 10.1016/j.jaci.2011.01.036
   World Health Organization,, Obesity and overweight 2020
   Yanovski SZ, 2015, JAMA-J AM MED ASSOC, V313, P1213, DOI 10.1001/jama.2015.1617
   Yanovski SZ, 2014, JAMA-J AM MED ASSOC, V311, P74, DOI 10.1001/jama.2013.281361
   Zhang A, 2015, J AM ACAD DERMATOL, V72, P606, DOI 10.1016/j.jaad.2014.12.013
NR 99
TC 7
Z9 7
U1 1
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2198
EI 2213-2201
J9 J ALLER CL IMM-PRACT
JI J. Allergy Clin. Immunol.-Pract.
PD JUN
PY 2021
VL 9
IS 6
BP 2245
EP 2254
DI 10.1016/j.jaip.2021.01.016
EA JUN 2021
PG 10
WC Allergy; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Allergy; Immunology
GA TM9DJ
UT WOS:000675846800014
PM 33516924
DA 2025-06-11
ER

PT J
AU Velehorschi, C
   Bleau, P
   Vermani, M
   Furtado, M
   Klassen, LJ
AF Velehorschi, Corina
   Bleau, Pierre
   Vermani, Monica
   Furtado, Melissa
   Klassen, Larry J.
TI Understanding the role of adjunctive nonpharmacological therapies in
   management of the multiple pathways to depression
SO PSYCHIATRY RESEARCH
LA English
DT Review
DE Metabolic syndrome; Adjunct therapy; Somatic therapies; Psychotherapy;
   Major depressive disorder
ID ST JOHNS WORT; SEROTONIN REUPTAKE INHIBITORS; NONSEASONAL MAJOR
   DEPRESSION; CANMAT CLINICAL GUIDELINES; METABOLIC SYNDROME; COGNITIVE
   THERAPY; BRIGHT LIGHT; DOUBLE-BLIND; SELF-HELP; INTERPERSONAL
   PSYCHOTHERAPY
AB Major depressive disorder (MDD) is a common disorder with a lifetime prevalence of 16.2% and the fourth highest cause of disability globally. It is hypothesized to be a syndromatic manifestation of multiple pathological processes leading to similar clinical manifestation. MDD is associated with at least three categories of peripheral hormone-type factors including neurotrophic factors, proinflammatory cytokines, and processes that impair regulation of the hypothalamic-pituitary-adrenocortical axis. Neuroimaging studies have identified functional abnormalities including subcortical systems associated with reward and emotion processing, medial prefrontal and anterior cingulate cortical regions and the lateral prefrontal cortical systems involved in cognitive control and voluntary emotion regulation. Studies investigating the effects of psychotherapy and pharmacotherapy on functional brain measures show normalization of brain function with return to euthymia. Nevertheless, approximately 50% of patients with MDD will not respond sufficiently and 60 to 70% will not achieve full remission with first-line pharmacotherapy, therefore clinicians strive to improve patient responses through the use of adjunct therapies. This review discusses recent research in the various biological processes associated with MDD as well as recent data in support of the use of adjunctive non-pharmacological therapies including psychotherapy, bibliotherapy, Internet therapy, "natural" or herbal approaches, exercise therapy, and somatic therapies. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Velehorschi, Corina] Windsor Reg Hosp, Toldo Neurobehav Inst, Windsor, ON, Canada.
   [Velehorschi, Corina] Western Univ, Schulich Sch Med, London, ON, Canada.
   [Bleau, Pierre] McGill Univ, Fac Med, Montreal, PQ, Canada.
   [Bleau, Pierre] McGill Univ, Ctr Hlth, Montreal, PQ, Canada.
   [Vermani, Monica; Furtado, Melissa] START Clin Mood & Anxiety Disorders, Toronto, ON, Canada.
   [Vermani, Monica] Lakehead Univ, Dept Psychol, Thunder Bay, ON P7B 5E1, Canada.
   [Klassen, Larry J.] Eden Mental Hlth Ctr, Winkler, MB, Canada.
C3 Western University (University of Western Ontario); McGill University;
   McGill University; Lakehead University
RP Velehorschi, C (corresponding author), Neurobehav Inst, 1453 Prince Rd, Windsor, ON N9C 3Z4, Canada.
EM corina_velehorschi@wrh.on.ca
FU Valeant Canada Ltd.
FX Publication costs associated with this supplement were paid to Elsevier
   by Valeant Canada Ltd.
CR Alpert JE, 2004, J CLIN PSYCHOPHARM, V24, P661, DOI 10.1097/01.jcp.0000145339.45794.cd
   Anderson L, 2005, BRIT J GEN PRACT, V55, P387
   Andersson Gerhard, 2009, Cognitive Behaviour Therapy, V38, P196, DOI 10.1080/16506070903318960
   [Anonymous], 2003, INV MENT HLTH, P1
   [Anonymous], J PARTICIPAT MED
   Bauer M, 2014, INT CLIN PSYCHOPHARM, V29, P16, DOI 10.1097/YIC.0000000000000011
   Bilich LL, 2008, CLIN PSYCHOL PSYCHOT, V15, P61, DOI 10.1002/cpp.562
   Blazer DG, 2003, J GERONTOL A-BIOL, V58, P249
   Brunoni AR, 2008, INT J NEUROPSYCHOPH, V11, P1169, DOI 10.1017/S1461145708009309
   Brustolim D, 2006, INT IMMUNOPHARMACOL, V6, P903, DOI 10.1016/j.intimp.2005.12.007
   Carek PJ, 2011, INT J PSYCHIAT MED, V41, P15, DOI 10.2190/PM.41.1.c
   Chiesa A, 2011, PSYCHIAT RES, V187, P441, DOI 10.1016/j.psychres.2010.08.011
   CLARKE DM, 1991, AUST NZ J PSYCHIAT, V25, P322, DOI 10.3109/00048679109062632
   Clarke Greg, 2009, Cognitive Behaviour Therapy, V38, P222, DOI 10.1080/16506070802675353
   Costello EJ, 2006, J CHILD PSYCHOL PSYC, V47, P1263, DOI 10.1111/j.1469-7610.2006.01682.x
   Craft S, 2004, LANCET NEUROL, V3, P169, DOI 10.1016/S1474-4422(04)00681-7
   Cuijpers P, 2009, J CLIN PSYCHIAT, V70, P1219, DOI 10.4088/JCP.09r05021
   Cuijpers P, 2008, J CLIN PSYCHIAT, V69, P1675, DOI 10.4088/JCP.v69n1102
   Daley A, 2008, J CLIN PSYCHOL MED S, V15, P140, DOI 10.1007/s10880-008-9105-z
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   Davidson Jonathan R T, 2010, J Clin Psychiatry, V71 Suppl E1, pe04, DOI 10.4088/JCP.9058se1c.04gry
   de Jonghe F, 2001, J AFFECT DISORDERS, V64, P217, DOI 10.1016/S0165-0327(00)00259-7
   DeRubeis RJ, 2005, ARCH GEN PSYCHIAT, V62, P409, DOI 10.1001/archpsyc.62.4.409
   Dimidjian S, 2006, J CONSULT CLIN PSYCH, V74, P658, DOI 10.1037/0022-006X.74.4.658
   Duman RS, 2004, BIOL PSYCHIAT, V56, P140, DOI 10.1016/j.biopsych.2004.02.033
   Fergusson DM, 2002, ARCH GEN PSYCHIAT, V59, P225, DOI 10.1001/archpsyc.59.3.225
   Fiske A, 2009, ANNU REV CLIN PSYCHO, V5, P363, DOI 10.1146/annurev.clinpsy.032408.153621
   Floyd M, 2006, BEHAV MODIF, V30, P281, DOI 10.1177/0145445503261176
   Floyd M, 2004, BEHAV MODIF, V28, P297, DOI 10.1177/0145445503259284
   Floyd M, 2003, J CLIN PSYCHOL, V59, P187, DOI 10.1002/jclp.10141
   Fournier JC, 2010, JAMA-J AM MED ASSOC, V303, P47, DOI 10.1001/jama.2009.1943
   Gehi A, 2005, ARCH INTERN MED, V165, P2508, DOI 10.1001/archinte.165.21.2508
   George MS, 2013, CURR OPIN PSYCHIATR, V26, P13, DOI 10.1097/YCO.0b013e32835ab46d
   George MS, 2010, ARCH GEN PSYCHIAT, V67, P507, DOI 10.1001/archgenpsychiatry.2010.46
   Godfrin KA, 2010, BEHAV RES THER, V48, P738, DOI 10.1016/j.brat.2010.04.006
   Goldman LS, 1999, J GEN INTERN MED, V14, P569, DOI 10.1046/j.1525-1497.1999.03478.x
   Grotto J., 2005, Primary Psychiatry, V12, P42
   Heiskanen TH, 2006, J CLIN PSYCHIAT, V67, P1422, DOI 10.4088/JCP.v67n0913
   HIBBELN JR, 1995, AM J CLIN NUTR, V62, P1
   Holsboer F, 2000, NEUROPSYCHOPHARMACOL, V23, P477, DOI 10.1016/S0893-133X(00)00159-7
   Horrocks LA, 1999, PHARMACOL RES, V40, P211, DOI 10.1006/phrs.1999.0495
   Horstmann S, 2009, PSYCHONEUROENDOCRINO, V34, P238, DOI 10.1016/j.psyneuen.2008.09.004
   Howland RH, 2010, POSTGRAD MED, V122, P66, DOI 10.3810/pgm.2010.07.2176
   Hung C.F., 2014, BRIT J PSYCHIAT
   Ising M, 2007, BIOL PSYCHIAT, V62, P47, DOI 10.1016/j.biopsych.2006.07.039
   Jazayeri S, 2008, AUST NZ J PSYCHIAT, V42, P192, DOI 10.1080/00048670701827275
   John AP, 2009, MED J AUSTRALIA, V190, P176, DOI 10.5694/j.1326-5377.2009.tb02342.x
   Keenan-Miller D, 2007, J ADOLESCENT HEALTH, V41, P256, DOI 10.1016/j.jadohealth.2007.03.015
   Keller MB, 2000, NEW ENGL J MED, V342, P1462, DOI 10.1056/NEJM200005183422001
   Kennedy SH, 2009, J AFFECT DISORDERS, V117, pS1, DOI 10.1016/j.jad.2009.06.043
   Kessler D, 2009, LANCET, V374, P628, DOI 10.1016/S0140-6736(09)61257-5
   Kessler RC, 2005, ARCH GEN PSYCHIAT, V62, P593, DOI 10.1001/archpsyc.62.6.593
   Kessler RC, 2003, JAMA-J AM MED ASSOC, V289, P3095, DOI 10.1001/jama.289.23.3095
   Khan A, 2002, J CLIN PSYCHOPHARM, V22, P40, DOI 10.1097/00004714-200202000-00007
   Khan A, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041778
   Kiecolt-Glaser JK, 2002, J PSYCHOSOM RES, V53, P873, DOI 10.1016/S0022-3999(02)00309-4
   Krogh J, 2011, J CLIN PSYCHIAT, V72, P529, DOI 10.4088/JCP.08r04913blu
   Kubera M, 2011, PROG NEURO-PSYCHOPH, V35, P744, DOI 10.1016/j.pnpbp.2010.08.026
   Kupfer DJ, 2012, LANCET, V379, P1045, DOI 10.1016/S0140-6736(11)60602-8
   Lam RW, 2009, J AFFECT DISORDERS, V117, pS26, DOI 10.1016/j.jad.2009.06.041
   Lewinsohn P., 1986, CONTROL YOUR DEPRESS
   Lewinsohn PM, 1998, CLIN PSYCHOL REV, V18, P765, DOI 10.1016/S0272-7358(98)00010-5
   Luppa M, 2012, INT J GERIATR PSYCH, V27, P286, DOI 10.1002/gps.2718
   Maiese K, 2007, CURR NEUROVASC RES, V4, P63, DOI 10.2174/156720207779940653
   Malberg JE, 2000, J NEUROSCI, V20, P9104, DOI 10.1523/jneurosci.20-24-09104.2000
   Martiny K, 2004, ACTA PSYCHIAT SCAND, V110, P7, DOI 10.1111/j.1600-0447.2004.00460_2.x
   Martiny K, 2005, ACTA PSYCHIAT SCAND, V112, P117, DOI 10.1111/j.1600-0447.2005.00574.x
   Martiny K, 2005, ACTA PSYCHIAT SCAND, V111, P453, DOI 10.1111/j.1600-0447.2005.00532.x
   McIntyre Roger S, 2007, Ann Clin Psychiatry, V19, P257, DOI 10.1080/10401230701653377
   McIntyre RS, 2009, CURR DIABETES REP, V9, P51, DOI 10.1007/s11892-009-0010-0
   Mead GE, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004366.pub4
   Meyer B, 2009, J MED INTERNET RES, V11, DOI 10.2196/jmir.1151
   Mischoulon D, 2012, J CLIN PSYCHIAT, V73, P843, DOI 10.4088/JCP.11m07139
   Motivala SJ, 2005, PSYCHOSOM MED, V67, P187, DOI 10.1097/01.psy.0000149259.72488.09
   Nahas R, 2011, CAN FAM PHYSICIAN, V57, P659
   Nemets B, 2002, AM J PSYCHIAT, V159, P477, DOI 10.1176/appi.ajp.159.3.477
   NIBUYA M, 1995, J NEUROSCI, V15, P7539
   Pampallona S, 2004, ARCH GEN PSYCHIAT, V61, P714, DOI 10.1001/archpsyc.61.7.714
   Papakostas George I, 2003, Curr Psychiatry Rep, V5, P460, DOI 10.1007/s11920-003-0085-2
   Papakostas GI, 2010, AM J PSYCHIAT, V167, P942, DOI 10.1176/appi.ajp.2009.09081198
   Park S., 2013, Psychosomatics
   Peet M, 2002, ARCH GEN PSYCHIAT, V59, P913, DOI 10.1001/archpsyc.59.10.913
   Perini S, 2009, AUST NZ J PSYCHIAT, V43, P571, DOI 10.1080/00048670902873722
   Perraton LG, 2010, J EVAL CLIN PRACT, V16, P597, DOI 10.1111/j.1365-2753.2009.01188.x
   Phillips M, 2008, MOL PSYCHIATR, V13, P833, DOI 10.1038/mp.2008.65
   Phipps A., 2003, GOOD MOOD GUIDE SELF
   Pizzagalli DA, 2011, NEUROPSYCHOPHARMACOL, V36, P183, DOI 10.1038/npp.2010.166
   Quidé Y, 2012, NEUROSCI BIOBEHAV R, V36, P626, DOI 10.1016/j.neubiorev.2011.09.004
   Qurran M. A., 2013, NEUROPSYCHOPHARMACOL
   Rahimi R, 2012, EXPERT OPIN DRUG MET, V8, P691, DOI 10.1517/17425255.2012.680886
   Raison CL, 2009, BIOL PSYCHIAT, V65, P296, DOI 10.1016/j.biopsych.2008.08.010
   Raison CL, 2006, TRENDS IMMUNOL, V27, P24, DOI 10.1016/j.it.2005.11.006
   Teixeira PJR, 2007, REV BRAS PSIQUIATR, V29, P330, DOI 10.1590/S1516-44462007000400007
   Richter N, 2010, EUR ARCH PSY CLIN N, V260, P41, DOI 10.1007/s00406-009-0013-5
   Ross SM, 2010, HOLIST NURS PRACT, V24, P303, DOI 10.1097/HNP.0b013e3181f103e4
   Rush A.J., 2002, PSYCHOTHERAPIES DEPR
   Sackeim HA, 2009, ARCH GEN PSYCHIAT, V66, P729, DOI 10.1001/archgenpsychiatry.2009.75
   Sarandol A, 2006, PROG NEURO-PSYCHOPH, V30, P1103, DOI 10.1016/j.pnpbp.2006.04.012
   Sarandol A, 2007, HUM PSYCHOPHARM CLIN, V22, P67, DOI 10.1002/hup.829
   Sarris J, 2012, PHARMACOPSYCHIATRY, V45, P275, DOI 10.1055/s-0032-1306348
   Schramm E, 2007, AM J PSYCHIAT, V164, P768, DOI 10.1176/appi.ajp.164.5.768
   Sen S, 2008, BIOL PSYCHIAT, V64, P527, DOI 10.1016/j.biopsych.2008.05.005
   Shaffer D, 1996, ARCH GEN PSYCHIAT, V53, P339
   Shelton RC, 2009, J CLIN PSYCHIAT, V70, P23, DOI 10.4088/JCP.8157su1c.05
   Songprakun W, 2012, J PSYCHIATR MENT HLT, V19, P647, DOI 10.1111/j.1365-2850.2011.01861.x
   Southwick SM, 2005, ANNU REV CLIN PSYCHO, V1, P255, DOI 10.1146/annurev.clinpsy.1.102803.143948
   Spangler DL, 1997, J CONSULT CLIN PSYCH, V65, P568, DOI 10.1037/0022-006X.65.4.568
   Strain JJ, 2008, PSYCHOSOMATICS, V49, P93, DOI 10.1176/appi.psy.49.2.93
   Su KP, 2003, EUR NEUROPSYCHOPHARM, V13, P267, DOI 10.1016/S0924-977X(03)00032-4
   Trivedi MH, 2011, J CLIN PSYCHIAT, V72, P677, DOI 10.4088/JCP.10m06743
   Veale D., 2008, Advances in Psychiatric Treatment, V14, P29, DOI DOI 10.1192/APT.BP.107.004051
   Viscogliosi G, 2013, INT J GERIATR PSYCH, V28, P242, DOI 10.1002/gps.3817
   Vöhringer PA, 2011, CLIN THER, V33, pB49, DOI 10.1016/j.clinthera.2011.11.019
   Weissman MM, 1999, JAMA-J AM MED ASSOC, V281, P1707, DOI 10.1001/jama.281.18.1707
   WEISSMAN MM, 1995, SCIENCE, V269, P799, DOI 10.1126/science.7638596
   Zobel I, 2011, ACTA PSYCHIAT SCAND, V123, P276, DOI 10.1111/j.1600-0447.2010.01671.x
NR 116
TC 12
Z9 12
U1 1
U2 31
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD DEC
PY 2014
VL 220
SU 1
BP S34
EP S44
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CA5LL
UT WOS:000348949800004
PM 25539873
DA 2025-06-11
ER

PT J
AU Lehto, SM
   Huotari, A
   Niskanen, L
   Herzig, KH
   Tolmunen, T
   Viinamäki, H
   Koivumaa-Honkanen, H
   Honkalampi, K
   Sinikallio, S
   Ruotsalainen, H
   Hintikka, J
AF Lehto, Soili M.
   Huotari, Anne
   Niskanen, Leo
   Herzig, Karl-Heinz
   Tolmunen, Tommi
   Viinamaki, Heimo
   Koivumaa-Honkanen, Heli
   Honkalampi, Kirsi
   Sinikallio, Sanna
   Ruotsalainen, Heli
   Hintikka, Jukka
TI Serum IL-7 and G-CSF in major depressive disorder
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE G-CSF; Growth factors; IL-7; Inflammation; Major depressive disorder
ID TORONTO-ALEXITHYMIA-SCALE; COLONY-STIMULATING FACTOR; METABOLIC
   SYNDROME; T-CELLS; CYTOKINES; INFLAMMATION; INTERLEUKIN-7;
   PATHOPHYSIOLOGY; EXPRESSION; IMMUNITY
AB Major depressive disorder (MDD) has been associated with dysregulated immune systems and impaired T cell function, but data on depression-related alterations in the levels of immunomodulatory growth factors are scarce. In order to further clarify the mechanisms underlying immune system dysregulation in depressed subjects, we examined the associations between MDD and serum levels of two immunomodulatory growth factors, interleukin (IL)-7 and granulocyte-colony stimulating factor (G-CSF), in 122 subjects (MDD with long-term symptomatology, n = 61; controls, n = 61). The MOD subjects had lowered levels of IL-7. In a model adjusted for age, gender and body mass index, subjects in the lowest tertile of IL-7 had a 3.4-fold increased likelihood for MDD (p = 0.010). Further adjustments for sleep disturbances, alcohol use, smoking, and metabolic syndrome did not alter these findings. Moreover, the exclusion of subjects with rheumatoid arthritis, coronary heart disease, or the use of non-steroidal anti-inflammatory medications or oral corticosteroids only slightly attenuated the findings. The G-CSF levels did not differ between the two groups. The lowering of the serum levels of IL-7, a regulator of T cell homeostasis, in MDD subjects may underlie the depression-related impaired T cell function. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Lehto, Soili M.; Herzig, Karl-Heinz; Tolmunen, Tommi; Viinamaki, Heimo; Koivumaa-Honkanen, Heli; Hintikka, Jukka] Kuopio Univ Hosp, Dept Psychiat, SF-70210 Kuopio, Finland.
   [Lehto, Soili M.; Niskanen, Leo; Herzig, Karl-Heinz; Tolmunen, Tommi; Viinamaki, Heimo; Koivumaa-Honkanen, Heli; Hintikka, Jukka] Univ Eastern Finland, Kuopio, Finland.
   [Huotari, Anne; Herzig, Karl-Heinz] Univ Kuopio, Dept Pharmaceut, FIN-70211 Kuopio, Finland.
   [Huotari, Anne; Herzig, Karl-Heinz; Ruotsalainen, Heli] Univ Oulu, Inst Biomed, Div Physiol & Bioctr Oulu, Oulu, Finland.
   [Niskanen, Leo] Kuopio Univ Hosp, Dept Med, SF-70210 Kuopio, Finland.
   [Koivumaa-Honkanen, Heli] Univ Oulu, Dept Clin Med, Oulu, Finland.
   [Koivumaa-Honkanen, Heli] Lapland Hosp Dist, Dept Psychiat, Rovaniemi 97140, Finland.
   [Honkalampi, Kirsi] Kuopio Psychiat Ctr, Kuopio, Finland.
   [Sinikallio, Sanna] Kuopio Univ Hosp, Dept Rehabil, SF-70210 Kuopio, Finland.
C3 University of Eastern Finland; University of Eastern Finland Hospital;
   Kuopio University Hospital; University of Eastern Finland; University of
   Eastern Finland; University of Oulu; University of Eastern Finland;
   University of Eastern Finland Hospital; Kuopio University Hospital;
   University of Oulu; Kuopio University Hospital; University of Eastern
   Finland; University of Eastern Finland Hospital
RP Lehto, SM (corresponding author), Kuopio Univ Hosp, Dept Psychiat, SF-70210 Kuopio, Finland.
EM Soili.Lehto@kuh.fi
RI Koivumaa-Honkanen, Heli/L-1274-2015
OI Lehto, Soili/0000-0003-4324-6679; Ruotsalainen, Heli/0000-0003-4923-5196
FU Kuopio University Hospital; Academy of Finland [116996]; Academy of
   Finland (AKA) [116996] Funding Source: Academy of Finland (AKA)
FX The authors thank Kaisa Haatainen, Ph.D., and Tarja Saharinen, M.N.Sc.,
   for their valuable contribution to the KUDEP study. SML was supported by
   Kuopio University Hospital EVO funding. HK-H was supported by the
   Academy of Finland (grant 116996).
CR Almeida OP, 2009, INT J EPIDEMIOL, V38, P1049, DOI 10.1093/ije/dyp199
   [Anonymous], 2001, JAMA, V285, P2486, DOI DOI 10.1001/JAMA.285.19.2486
   Babyak MA, 2004, PSYCHOSOM MED, V66, P411, DOI 10.1097/01.psy.0000127692.23278.a9
   BAGBY RM, 1994, J PSYCHOSOM RES, V38, P33, DOI 10.1016/0022-3999(94)90006-X
   BAGBY RM, 1994, J PSYCHOSOM RES, V38, P23, DOI 10.1016/0022-3999(94)90005-1
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   Benedict C, 2007, BRAIN BEHAV IMMUN, V21, P1058, DOI 10.1016/j.bbi.2007.04.004
   Calzascia T, 2008, P NATL ACAD SCI USA, V105, P2999, DOI 10.1073/pnas.0712135105
   Chapman BP, 2009, BRAIN BEHAV IMMUN, V23, P636, DOI 10.1016/j.bbi.2008.12.009
   Curtin NM, 2009, BRAIN BEHAV IMMUN, V23, P371, DOI 10.1016/j.bbi.2008.12.010
   de Jager W, 2003, CLIN DIAGN LAB IMMUN, V10, P133, DOI 10.1128/CDLI.10.1.133-139.2003
   Dhabhar FS, 2009, J PSYCHIATR RES, V43, P962, DOI 10.1016/j.jpsychires.2009.05.010
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Elshal MF, 2006, METHODS, V38, P317, DOI 10.1016/j.ymeth.2005.11.010
   Fry TJ, 2002, BLOOD, V99, P3892, DOI 10.1182/blood.V99.11.3892
   Genser B, 2007, BMC IMMUNOL, V8, DOI 10.1186/1471-2172-8-27
   Gimeno D, 2009, PSYCHOL MED, V39, P413, DOI 10.1017/S0033291708003723
   Gringhuis SI, 1997, BLOOD, V90, P2690, DOI 10.1182/blood.V90.7.2690.2690_2690_2700
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Himmerich H, 2006, BIOL PSYCHIAT, V60, P882, DOI 10.1016/j.biopsych.2006.03.075
   Irwin MR, 2007, BRAIN BEHAV IMMUN, V21, P374, DOI 10.1016/j.bbi.2007.01.010
   Jiang Q, 2005, CYTOKINE GROWTH F R, V16, P513, DOI 10.1016/j.cytogfr.2005.05.004
   Khairova RA, 2009, INT J NEUROPSYCHOPH, V12, P561, DOI 10.1017/S1461145709009924
   Kim HR, 2008, CRIT REV IMMUNOL, V28, P325, DOI 10.1615/CritRevImmunol.v28.i4.40
   Kim YK, 2007, PROG NEURO-PSYCHOPH, V31, P1044, DOI 10.1016/j.pnpbp.2007.03.004
   Kleinschnitz C, 2004, MOL BRAIN RES, V131, P73, DOI 10.1016/j.molbrainres.2004.08.011
   Koivumaa-Honkanen H, 2000, AM J EPIDEMIOL, V152, P983, DOI 10.1093/aje/152.10.983
   Lehto SM, 2010, ACTA PSYCHIAT SCAND, V121, P209, DOI 10.1111/j.1600-0447.2009.01463.x
   Lehto SM, 2010, PSYCHONEUROENDOCRINO, V35, P226, DOI 10.1016/j.psyneuen.2009.06.007
   Leng SX, 2008, J GERONTOL A-BIOL, V63, P879, DOI 10.1093/gerona/63.8.879
   Maes M, 2009, METAB BRAIN DIS, V24, P27, DOI 10.1007/s11011-008-9118-1
   Merikangas KR, 2003, ARCH GEN PSYCHIAT, V60, P993, DOI 10.1001/archpsyc.60.9.993
   Michaelson MD, 1996, DEV BIOL, V179, P251, DOI 10.1006/dbio.1996.0255
   Miller AH, 2010, BRAIN BEHAV IMMUN, V24, P1, DOI 10.1016/j.bbi.2009.09.009
   Miller AH, 2009, BIOL PSYCHIAT, V65, P732, DOI 10.1016/j.biopsych.2008.11.029
   Mittal VA, 2011, PSYCHIAT RES, V189, P158, DOI 10.1016/j.psychres.2011.06.006
   Myint AM, 2005, J AFFECT DISORDERS, V88, P167, DOI 10.1016/j.jad.2005.07.008
   Pitsavos C, 2006, ATHEROSCLEROSIS, V185, P320, DOI 10.1016/j.atherosclerosis.2005.06.001
   Raison CL, 2006, TRENDS IMMUNOL, V27, P24, DOI 10.1016/j.it.2005.11.006
   Schiepers OJG, 2005, PROG NEURO-PSYCHOPH, V29, P201, DOI 10.1016/j.pnpbp.2004.11.003
   Schneider A, 2005, CELL CYCLE, V4, P1753, DOI 10.4161/cc.4.12.2213
   Schnepf M, 2005, TOP CAN WEED SCI, V1, P15
   Simon NM, 2008, EUR NEUROPSYCHOPHARM, V18, P230, DOI 10.1016/j.euroneuro.2007.06.004
   SMITH RS, 1991, MED HYPOTHESES, V35, P298, DOI 10.1016/0306-9877(91)90272-Z
   Stewart JC, 2009, BRAIN BEHAV IMMUN, V23, P936, DOI 10.1016/j.bbi.2009.04.011
   Surh CD, 2006, IMMUNOL REV, V211, P154, DOI 10.1111/j.0105-2896.2006.00401.x
   Sutcigil L, 2007, CLIN DEV IMMUNOL, DOI 10.1155/2007/76396
   Viinamäki H, 2009, ACTA PSYCHIAT SCAND, V120, P23, DOI 10.1111/j.1600-0447.2008.01333.x
   Whooley MA, 2007, BIOL PSYCHIAT, V62, P314, DOI 10.1016/j.biopsych.2006.10.016
   Williams JBW, 2003, Structured Interview Guide For the Hamilton Depression Rating Scale with Atypical Depression Supplement
   Zaharia MD, 2000, J AFFECT DISORDERS, V58, P1, DOI 10.1016/S0165-0327(99)00100-7
NR 51
TC 33
Z9 35
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD AUG 16
PY 2010
VL 34
IS 6
BP 846
EP 851
DI 10.1016/j.pnpbp.2010.03.033
PG 6
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 642EX
UT WOS:000281187800006
PM 20382196
DA 2025-06-11
ER

PT J
AU Doretto, L
   Mari, FC
   Chaves, AC
AF Doretto, Larissa
   Mari, Flora Chaves
   Chaves, Ana Cristina
TI Polycystic Ovary Syndrome and Psychotic Disorder
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE polycystic ovary syndrome; psychotic disorder; women; antipsychotic
   drugs; schizophrenia
ID TYPE-2 DIABETES-MELLITUS; PSYCHIATRIC-DISORDERS; ANTIPSYCHOTIC-DRUGS;
   METABOLIC SYNDROME; RISK; WOMEN; SCHIZOPHRENIA; PREVALENCE;
   PATHOPHYSIOLOGY; INFERTILITY
AB Polycystic ovary syndrome (PCOS), a disease that usually emerges during adolescence, is characterized by hormonal imbalance and ovarian dysfunction. The prevalence can vary between 5.6 to 21.3% in women and 6% in adolescent girls. This discrepancy is related to the population studied and the diagnostic criteria used. The underlying pathophysiology of PCOS is not fully understood, but it can lead to a number of co-morbidities, including hypertension, diabetes, dyslipidemia, and also, mental health disorders. Clinical and preclinical data indicate neuroendocrine involvement with dysfunction in gamma-Aminobutyric acid (GABA) signaling and neuronal androgen receptors that might reduce hypothalamic sensitivity and lead to an impairment of estradiol and progesterone feedback. Based on these assumptions, the aims of this paper are to review the association of PCOS and psychotic disorders in order to address the burden of women comorbid for both conditions.
C1 [Doretto, Larissa; Chaves, Ana Cristina] Univ Fed Sao Paulo UNIFESP, Dept Psychiat, Episode Psychosis Program 1, Sao Paulo, Brazil.
   [Mari, Flora Chaves] Santa Casa Med Sch Sao Paulo, Sao Paulo, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP)
RP Chaves, AC (corresponding author), Univ Fed Sao Paulo UNIFESP, Dept Psychiat, Episode Psychosis Program 1, Sao Paulo, Brazil.
EM anachaves@terra.com.br
RI Chaves, Ana/A-5329-2012
OI Chaves, Ana Cristina/0000-0002-7777-5598
CR Axelsson S, 2007, CLIN EXP PHARMACOL P, V34, P775, DOI 10.1111/j.1440-1681.2007.04650.x
   Azziz R, 2016, NAT REV DIS PRIMERS, V2, DOI 10.1038/nrdp.2016.57
   Bahr SM, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.135
   Bhattacharya SM, 2008, J OBSTET GYNAECOL RE, V34, P62, DOI 10.1111/j.1447-0756.2007.00685.x
   Blay SL, 2016, NEUROPSYCH DIS TREAT, V12, P2895, DOI 10.2147/NDT.S91700
   Caldwell ASL, 2017, P NATL ACAD SCI USA, V114, pE3334, DOI 10.1073/pnas.1616467114
   Cesta CE, 2016, PSYCHONEUROENDOCRINO, V73, P196, DOI 10.1016/j.psyneuen.2016.08.005
   Chachamovich JR, 2010, J PSYCHOSOM OBST GYN, V31, P101, DOI 10.3109/0167482X.2010.481337
   Conaglen HA, 2003, J SEX MARITAL THER, V29, P255, DOI 10.1080/00926230390195498
   Coyle C, 2019, MOL CELL ENDOCRINOL, V498, DOI 10.1016/j.mce.2019.110561
   Davey KJ, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.83
   Davey KJ, 2012, PSYCHOPHARMACOLOGY, V221, P155, DOI 10.1007/s00213-011-2555-2
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P138
   Deng YY, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-14534-2
   Deuchar N, 1998, J PSYCHOSOM OBST GYN, V19, P104, DOI 10.3109/01674829809048503
   Dunaif A, 1999, J CLIN ENDOCR METAB, V84, P2975, DOI 10.1210/jc.84.8.2975
   Franks S, 2008, HUM REPROD UPDATE, V14, P367, DOI 10.1093/humupd/dmn015
   Galling B, 2016, JAMA PSYCHIAT, V73, P247, DOI 10.1001/jamapsychiatry.2015.2923
   González-Rodríguez A, 2019, THER ADV PSYCHOPHARM, V9, DOI 10.1177/2045125319859973
   Guo Y, 2016, PLASMONICS, V11, P11, DOI [10.1371/journal.pone.0156323, 10.1007/s11468-015-0008-1]
   Haddad PM, 2007, CNS DRUGS, V21, P911, DOI 10.2165/00023210-200721110-00004
   Ibáñez L, 2017, HORM RES PAEDIAT, V88, P371, DOI 10.1159/000479371
   Joffe H, 2008, ANN NY ACAD SCI, V1135, P219, DOI 10.1196/annals.1429.030
   Joham AE, 2015, J WOMENS HEALTH, V24, P299, DOI 10.1089/jwh.2014.5000
   Johannesen L, 2018, CLIN PHARMACOL THER, V103, P304, DOI 10.1002/cpt.783
   Kahn SE, 2014, LANCET, V383, P1068, DOI 10.1016/S0140-6736(13)62154-6
   Kao ACC, 2018, TRANSL PSYCHIAT, V8, DOI 10.1038/s41398-018-0116-8
   Khalil RB, 2012, CLIN NEUROPHARMACOL, V35, P141, DOI 10.1097/WNF.0b013e31824d5288
   Leucht S, 2013, LANCET, V382, P951, DOI 10.1016/S0140-6736(13)60733-3
   Lizneva D, 2016, FERTIL STERIL, V106, P6, DOI 10.1016/j.fertnstert.2016.05.003
   Manu P, 2012, J CLIN PSYCHIAT, V73, P460, DOI 10.4088/JCP.10m06822
   Moran L, 2010, J PSYCHOSOM OBST GYN, V31, P24, DOI 10.3109/01674820903477593
   Morgan AP, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0115225
   Musil R, 2015, EXPERT OPIN DRUG SAF, V14, P73, DOI 10.1517/14740338.2015.974549
   Nordholm D, 2018, PSYCHONEUROENDOCRINO, V92, P72, DOI 10.1016/j.psyneuen.2018.03.015
   Orio F, 2006, FERTIL STERIL, V86, pS20, DOI 10.1016/j.fertnstert.2006.03.003
   Page H, 2008, SCHIZOPHR RES, V102, P218, DOI [10.1016/S0920-9964(08)70659-5, DOI 10.1016/S0920-9964(08)70659-5]
   Riecher-Rössler A, 2017, LANCET PSYCHIAT, V4, P63, DOI 10.1016/S2215-0366(16)30379-0
   Ruddenklau A, 2019, ENDOCRINOLOGY, V160, P2230, DOI 10.1210/en.2019-00428
   Seeman MV, 2012, ACTA PSYCHIAT SCAND, V125, P363, DOI 10.1111/j.1600-0447.2011.01822.x
   Seeman Mary V, 2011, Clin Schizophr Relat Psychoses, V5, P142, DOI 10.3371/CSRP.5.3.4
   Tata B, 2018, NAT MED, V24, P834, DOI 10.1038/s41591-018-0035-5
   Teede H., 2018, INT EVIDENCE BASED G
   Torres PJ, 2018, J CLIN ENDOCR METAB, V103, P1502, DOI 10.1210/jc.2017-02153
   Veltman-Verhulst SM, 2012, HUM REPROD UPDATE, V18, P638, DOI 10.1093/humupd/dms029
   Verma S, 2017, DIAB MET SYND CLIN R, V11, P73, DOI 10.1016/j.dsx.2016.06.017
   Witchel SF, 2019, J ENDOCR SOC, V3, P1545, DOI 10.1210/js.2019-00078
   Zhang N, 2008, EUR J ENDOCRINOL, V158, P255, DOI 10.1530/EJE-07-0576
   Zhang-Wong J H, 2002, Arch Womens Ment Health, V5, P93, DOI 10.1007/s00737-002-0002-4
NR 49
TC 25
Z9 26
U1 0
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JUN 10
PY 2020
VL 11
AR 543
DI 10.3389/fpsyt.2020.00543
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA MD3QM
UT WOS:000543885700001
PM 32587538
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Al-Gayyar, MMH
   Shams, MEE
   Barakat, EAME
AF Al-Gayyar, Mohammed M. H.
   Shams, Mohamed E. E.
   Barakat, Enaase A. M. E.
TI Fish oil improves lipid metabolism and ameliorates inflammation in
   patients with metabolic syndrome: Impact of nonalcoholic fatty liver
   disease
SO PHARMACEUTICAL BIOLOGY
LA English
DT Article
DE Fatty liver; metabolic syndrome; fish oil; lipid profile; oxidative
   stress; antioxidants; TNF-alpha and IL-6
ID INSULIN-RESISTANCE; OBESE-PATIENTS; STEATOHEPATITIS; ALPHA;
   PATHOGENESIS; PREVALENCE; MANAGEMENT; STEATOSIS; EXPOSURE; NECROSIS
AB Context: Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent in Egypt, in parallel with increasing obesity. NAFLD can lead to liver inflammation, fibrosis and cirrhosis. NAFLD appears tightly linked with metabolic syndrome (MetS).
   Objective: Examine the impact of dietary fish oil on human patients with MetS and NAFLD.
   Materials and methods: One hundred and forty patients were enrolled in the current study and classified into two groups: patients with both MetS and NAFLD and patients with MetS alone. Sixty-four patients were treated with daily supplementation of 2 g of fish oil for 6 months. Markers of hyperlipidemia and oxidative stress, hydrogen peroxide (H2O2) and malondialdhyde (MDA), as well as proinflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), were analyzed.
   Results: Patients without fish oil exhibited significant increases in triglycerides (TGs), low-density lipoprotein (LDL), H2O2 and MDA that were associated with significantly elevated TNF-alpha and IL-6 compared to controls. Furthermore, patients with both NAFLD and MetS showed significant increase in H2O2, MDA, TNF-alpha and IL-6 levels compared with MetS group (p < 0.05). Treatment with fish oil reduced serum level of TG, LDL-cholesterol (LDL-C), H2O2, MDA, TNF-alpha and IL-6 levels in patients and did not affect the control levels.
   Discussion and conclusion: Patients with NAFLD had bad lipid profile through a mechanism that involved developed redox imbalance, characterized by boosted free-radical activity and lipid peroxidation enhancing the release of proinflammatory cytokines leading to increased MetS risk and liver damage. However, daily treatment of patients with fish oil for 6 months improved lipid profile and blocked the oxidative stress and cytokines release.
C1 [Al-Gayyar, Mohammed M. H.] Univ Georgia, Coll Pharm, Program Clin & Expt Therapeut, Augusta, GA 30912 USA.
   [Al-Gayyar, Mohammed M. H.] Univ Mansoura, Dept Biochem, Fac Pharm, Mansoura, Egypt.
   [Al-Gayyar, Mohammed M. H.] Charlie Norwood Vet Affairs Med Ctr, Augusta, GA USA.
   [Shams, Mohamed E. E.] Univ Mansoura, Dept Pharmaceut, Fac Pharm, Mansoura, Egypt.
   [Barakat, Enaase A. M. E.] Univ Mansoura, Dept Internal Med, Fac Med, Mansoura, Egypt.
C3 University System of Georgia; University of Georgia; Egyptian Knowledge
   Bank (EKB); Mansoura University; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); Charlie Norwood VA Medical Center;
   Egyptian Knowledge Bank (EKB); Mansoura University; Egyptian Knowledge
   Bank (EKB); Mansoura University
RP Al-Gayyar, MMH (corresponding author), Univ Georgia, Coll Pharm, Program Clin & Expt Therapeut, 1120 15th St,HM-1200, Augusta, GA 30912 USA.
EM mhgayyar@yahoo.com
RI Shams, Mohamed/AAB-5990-2020; Al-Gayyar, Mohammed/E-8250-2014
OI Al-Gayyar, Mohammed/0000-0003-4777-3919; Shams, Mohamed E.
   E./0000-0003-2392-2852
CR Al-Gayyar MMH, 2007, J PHARM PHARMACOL, V59, P409, DOI 10.1211/jpp.59.3.0011
   Bedogni G, 2005, HEPATOLOGY, V42, P44, DOI 10.1002/hep.20734
   Begriche K, 2006, MITOCHONDRION, V6, P1, DOI 10.1016/j.mito.2005.10.004
   Brown JM, 2010, ARTERIOSCL THROM VAS, V30, P24, DOI 10.1161/ATVBAHA.109.198036
   Capanni M, 2006, ALIMENT PHARM THER, V23, P1143, DOI 10.1111/j.1365-2036.2006.02885.x
   Carter-Kent C, 2008, AM J GASTROENTEROL, V103, P1036, DOI 10.1111/j.1572-0241.2007.01709.x
   Colicchio P, 2005, ANN NUTR METAB, V49, P289, DOI 10.1159/000087295
   Copaci Ionel, 2006, J Gastrointestin Liver Dis, V15, P363
   De Ley M., 2007, COCHRANE DB SYST REV, V17
   Deen D, 2004, AM FAM PHYSICIAN, V69, P2875
   Duvnjak M, 2007, WORLD J GASTROENTERO, V13, P4539, DOI 10.3748/wjg.v13.i34.4539
   El-Assal O, 2004, CELL MOL IMMUNOL, V1, P205
   El-Mesery ME, 2009, CELL DIV, V4, DOI 10.1186/1747-1028-4-6
   Ford ES, 2005, DIABETES CARE, V28, P2745, DOI 10.2337/diacare.28.11.2745
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   García-Galiano D, 2007, OBES SURG, V17, P493, DOI 10.1007/s11695-007-9087-1
   Haukeland JW, 2006, J HEPATOL, V44, P1167, DOI 10.1016/j.jhep.2006.02.011
   Iimuro Y, 1997, HEPATOLOGY, V26, P1530
   Jin XL, 2006, HEPATOLOGY, V43, P474, DOI 10.1002/hep.21087
   Mensink RP, 2008, CURR OPIN LIPIDOL, V19, P25, DOI 10.1097/MOL.0b013e3282f382ea
   Paschos P, 2009, HIPPOKRATIA, V13, P9
   Poniachik J, 2006, CYTOKINE, V33, P252, DOI 10.1016/j.cyto.2006.02.006
   Portincasa P, 2005, CLIN BIOCHEM, V38, P203, DOI 10.1016/j.clinbiochem.2004.10.014
   Puder JJ, 2005, J CLIN ENDOCR METAB, V90, P6014, DOI 10.1210/jc.2005-1002
   Spadaro L, 2006, J HEPATOL, V44, pS264, DOI 10.1016/S0168-8278(06)80718-X
   Targher G, 2007, ATHEROSCLEROSIS, V191, P235, DOI 10.1016/j.atherosclerosis.2006.08.021
   Valenti L, 2002, GASTROENTEROLOGY, V122, P274, DOI 10.1053/gast.2002.31065
   Wang PW, 2008, DIABETES RES CLIN PR, V81, P202, DOI 10.1016/j.diabres.2008.04.014
   Weatherill AR, 2005, J IMMUNOL, V174, P5390, DOI 10.4049/jimmunol.174.9.5390
   Wieckowska A, 2008, AM J GASTROENTEROL, V103, P1372, DOI 10.1111/j.1572-0241.2007.01774.x
NR 30
TC 19
Z9 21
U1 0
U2 16
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1388-0209
J9 PHARM BIOL
JI Pharm. Biol.
PD MAR
PY 2012
VL 50
IS 3
BP 297
EP 303
DI 10.3109/13880209.2011.604088
PG 7
WC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
GA 891ZW
UT WOS:000300256800006
PM 22103753
OA Bronze
DA 2025-06-11
ER

PT J
AU Mehta, PK
   Huang, JW
   Levit, RD
   Malas, W
   Waheed, N
   Merz, CNB
AF Mehta, Puja K.
   Huang, Jingwen
   Levit, Rebecca D.
   Malas, Waddah
   Waheed, Nida
   Merz, C. Noel Bairey
TI Ischemia and no obstructive coronary arteries (INOCA): A narrative
   review
SO ATHEROSCLEROSIS
LA English
DT Review
DE Coronary microvascular; Coronary vasospasm; Myocardial ischemia;
   Endothelial dysfunction
ID INDUCED MYOCARDIAL-ISCHEMIA; ENHANCED EXTERNAL COUNTERPULSATION; CARDIAC
   SYNDROME-X; COMPUTED-TOMOGRAPHY ANGIOGRAPHY; LEFT-VENTRICULAR FUNCTION;
   AUTONOMIC NERVOUS-SYSTEM; STELLATE GANGLION BLOCK;
   HEART-RATE-VARIABILITY; FLOW VELOCITY RESERVE; QUALITY-OF-LIFE
AB Myocardial ischemia with no obstructive coronary arteries (INOCA) is a chronic coronary syndrome condition that is increasingly being recognized as a substantial contributor to adverse cardiovascular mortality and out-comes, including myocardial infarction and heart failure with preserved ejection fraction (HFpEF). While INOCA occurs in both women and men, women are more likely to have the finding of INOCA and are more adversely impacted by angina, with recurrent hospitalizations and a lower quality of life with this condition. Abnormal epicardial coronary vascular function and coronary microvascular dysfunction (CMD) have been identified in a majority of INOCA patients on invasive coronary function testing. CMD can co-exist with obstructive epicardial coronary artery disease (CAD), diffuse non-obstructive epicardial CAD, and with coronary vasospasm. Epicardial vasospasm can also occur with normal coronary arteries that have no atherosclerotic plaque on intravascular imaging. While all predisposing factors are not clearly understood, cardiometabolic risk factors, and endothelium dependent and independent mechanisms that increase oxidative stress and inflammation are associated with microvascular injury, CMD and INOCA. Cardiac autonomic dysfunction has also been implicated in abnormal vasoreactivity and persistent symptoms. INOCA is under-recognized and under-diagnosed, partly due to the heterogenous patient populations and mechanisms. However, diagnostic testing methods are available to guide INOCA management. Treatment of INOCA is evolving, and focuses on cardiac risk factor control, improving ischemia, reducing atherosclerosis progression, and improving angina and quality of life. This review focuses on INOCA, relations to HFpEF, available diagnostics, current and investigational therapeutic strategies, and knowledge gaps in this condition.
C1 [Mehta, Puja K.] Emory Univ, Sch Med, Emory Womens Heart Ctr, Div Cardiol, Atlanta, GA USA.
   [Mehta, Puja K.] Emory Univ, Sch Med, Emory Clin Cardiovasc Res Inst, Div Cardiol, Atlanta, GA USA.
   [Huang, Jingwen] Emory Univ, Sch Med, J Willis Hurst Internal Med Residency Training Pro, Atlanta, GA USA.
   [Levit, Rebecca D.] Emory Univ, Sch Med, Div Cardiol, Atlanta, GA USA.
   [Malas, Waddah] Loyola Med Ctr, Cardiovasc Dis Fellowship Training Program, Chicago, IL USA.
   [Waheed, Nida] Emory Univ, Sch Med, Cardiovasc Dis Fellowship Training Program, Atlanta, GA USA.
   [Merz, C. Noel Bairey] Cedars Sinai Smidt Heart Inst, Barbra Streisand Womens Heart Ctr, Los Angeles, CA USA.
   [Mehta, Puja K.] Emory Clin Cardiovasc Res Inst, Emory Womens Heart Ctr, Womens Translat Cardiovasc Res, 1462 Clifton Rd,Suite 505, Atlanta, GA 30322 USA.
C3 Emory University; Emory University; Emory University; Emory University;
   Loyola University Chicago; Emory University; Cedars Sinai Medical Center
RP Mehta, PK (corresponding author), Emory Clin Cardiovasc Res Inst, Emory Womens Heart Ctr, Womens Translat Cardiovasc Res, 1462 Clifton Rd,Suite 505, Atlanta, GA 30322 USA.
EM pkmehta@emory.edu
RI Waheed, Nida/AAM-6077-2020; Huang, Jingwen/GWC-3188-2022
OI Mehta, Puja/0000-0002-5678-812X
FU National Institutes of Health [R01HL124649, U54 AG065141,
   1U54AG062334-01, 1R01HL157311]; Edythe L. Broad Fellowship; Constance
   Austin Women's Heart Research Fellowship; Cedars-Sinai Medical Center;
   Barbra Streisand Women's Cardiovascular Research and Education Program;
   Society for Women's Health Research (SWHR), Washington, DC; Linda Joy
   Pollin Women's Heart Health Program; Erika Glazer Women's Heart Health
   Project; Adelson Family Foundation, Cedars-Sinai Medical Center, Los
   Angeles, California
FX This work was supported by the National Institutes of Health
   R01HL124649, U54 AG065141, 1U54AG062334-01, 1R01HL157311, the Edythe L.
   Broad and the Constance Austin Women's Heart Research Fellowships,
   Cedars-Sinai Medical Center, the Barbra Streisand Women's Cardiovascular
   Research and Education Program, Cedars -Sinai Medical Center, The
   Society for Women's Health Research (SWHR), Washington, DC, the Linda
   Joy Pollin Women's Heart Health Program, the Erika Glazer Women's Heart
   Health Project, and the Adelson Family Foundation, Cedars-Sinai Medical
   Center, Los Angeles, California.
CR Agarwal M, 2013, CARDIOVASC DIAGN THE, V3, P146, DOI 10.3978/j.issn.2223-3652.2013.08.01
   Agewall S, 2017, EUR HEART J, V38, P143, DOI 10.1093/eurheartj/ehw149
   Agostini D, 2008, EUR J NUCL MED MOL I, V35, P535, DOI 10.1007/s00259-007-0639-3
   Ahmad A, 2021, EUR J HEART FAIL, V23, P765, DOI 10.1002/ejhf.2010
   Al-Badri A, 2020, J AM HEART ASSOC, V9, DOI 10.1161/JAHA.119.015515
   AlBadri A, 2019, JACC-CARDIOVASC INTE, V12, P1519, DOI 10.1016/j.jcin.2019.05.003
   AlBadri A, 2019, J AM COLL CARDIOL, V73, P684, DOI 10.1016/j.jacc.2018.11.040
   AlBadri A, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0177684
   Arnold JR, 2022, JACC-CARDIOVASC IMAG, V15, P1001, DOI 10.1016/j.jcmg.2021.11.022
   Arora RR, 1999, J AM COLL CARDIOL, V33, P1833, DOI 10.1016/S0735-1097(99)00140-0
   Azancot I, 2003, CIRCULATION, V107, P422, DOI 10.1161/01.CIR.0000046488.52939.BF
   Bainey KR, 2018, INT J CARDIOL, V264, P12, DOI 10.1016/j.ijcard.2018.04.004
   Bajaj NS, 2018, J AM COLL CARDIOL, V72, P707, DOI 10.1016/j.jacc.2018.05.049
   Bechsgaard DF, 2019, INT J CARDIOL, V293, P1, DOI 10.1016/j.ijcard.2019.07.048
   Beltrame JF, 2017, EUR HEART J, V38, P2565, DOI 10.1093/eurheartj/ehv351
   Bière L, 2017, WORLD J CARDIOL, V9, P268, DOI 10.4330/wjc.v9.i3.268
   BUGIARDINI R, 1989, AM J CARDIOL, V63, P286, DOI 10.1016/0002-9149(89)90332-9
   Bybee KA, 2004, AM J CARDIOL, V94, P343, DOI 10.1016/j.amjcard.2004.04.030
   CANNON RO, 1990, J AM COLL CARDIOL, V16, P1359, DOI 10.1016/0735-1097(90)90377-2
   CANNON RO, 1994, NEW ENGL J MED, V330, P1411, DOI 10.1056/NEJM199405193302003
   CANNON RO, 1985, AM J CARDIOL, V56, P242, DOI 10.1016/0002-9149(85)90842-2
   Cargnoni A, 2000, CARDIOVASC RES, V47, P556, DOI 10.1016/S0008-6363(00)00082-1
   Cassar A, 2009, CIRC-CARDIOVASC INTE, V2, P237, DOI 10.1161/CIRCINTERVENTIONS.108.841056
   Cemin R, 2008, CORONARY ARTERY DIS, V19, P1, DOI 10.1097/MCA.0b013e3282f18e8d
   CHAUHAN A, 1994, J AM COLL CARDIOL, V24, P329, DOI 10.1016/0735-1097(94)90284-4
   Chen JW, 1997, AM J CARDIOL, V80, P32
   Chester M, 2000, PAIN, V87, P103, DOI 10.1016/S0304-3959(00)00270-0
   Choo EH, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.119.011990
   Chow BJW, 2021, EUR HEART J-CARD IMG, V22, P331, DOI 10.1093/ehjci/jeaa196
   Chung CP, 2007, CLIN RHEUMATOL, V26, P1228, DOI 10.1007/s10067-007-0548-7
   Claudio CP, 2018, CLIN CARDIOL, V41, P185, DOI 10.1002/clc.22894
   Corban MT, 2018, J AM HEART ASSOC, V7, DOI 10.1161/JAHA.118.009881
   Corban MT, 2022, CIRC RES, V130, P326, DOI 10.1161/CIRCRESAHA.121.319644
   Cortigiani L, 2008, AM J CARDIOL, V102, P1718, DOI 10.1016/j.amjcard.2008.08.023
   Crea F, 2004, HEART, V90, P457, DOI 10.1136/hrt.2003.020594
   Crea F, 2014, EUR HEART J, V35, P1101, DOI 10.1093/eurheartj/eht513
   Cui LJ, 2022, CARDIOVASC DIAGN THE, V12, P166, DOI 10.21037/cdt-21-705
   De Matos LDNJ, 2004, J CARD FAIL, V10, P496, DOI 10.1016/j.cardfail.2004.03.006
   deBruyne B, 1996, CIRCULATION, V94, P1842, DOI 10.1161/01.CIR.94.8.1842
   Dhawan SS, 2012, ATHEROSCLEROSIS, V223, P384, DOI 10.1016/j.atherosclerosis.2012.05.034
   Di Carli MF, 2003, J AM COLL CARDIOL, V41, P1387, DOI 10.1016/S0735-1097(03)00166-9
   Di Monaco A, 2010, AM J CARDIOL, V106, P1813, DOI 10.1016/j.amjcard.2010.07.052
   DiCarli MF, 1997, NEW ENGL J MED, V336, P1208, DOI 10.1056/NEJM199704243361703
   Dryer K, 2018, AM J PHYSIOL-HEART C, V314, pH1033, DOI 10.1152/ajpheart.00680.2017
   Durante W, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22168786
   Dzavík V, 2007, EUR HEART J, V28, P1109, DOI 10.1093/eurheartj/ehm075
   EMDIN M, 1989, J AM COLL CARDIOL, V14, P1450, DOI 10.1016/0735-1097(89)90380-X
   Faccini A, 2016, EUR HEART J, V37, P1799, DOI 10.1093/eurheartj/ehw018
   Fearon WF, 2003, CIRCULATION, V107, P3129, DOI 10.1161/01.CIR.0000080700.98607.D1
   Feenstra RGT, 2022, EUROINTERVENTION, V17, P1271, DOI 10.4244/EIJ-D-21-00402
   Ford TJ, 2020, JACC-CARDIOVASC INTE, V13, P1847, DOI 10.1016/j.jcin.2020.05.052
   Ford TJ, 2018, J AM COLL CARDIOL, V72, P2841, DOI 10.1016/j.jacc.2018.09.006
   Franssen C, 2016, JACC-HEART FAIL, V4, P312, DOI 10.1016/j.jchf.2015.10.007
   Galiuto L, 2007, AM J CARDIOL, V99, P1378, DOI 10.1016/j.amjcard.2006.12.070
   Gallinoro E, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.765071
   Gallone G, 2020, JACC-CARDIOVASC INTE, V13, P1, DOI 10.1016/j.jcin.2019.08.055
   Ghadri JR, 2018, EUR HEART J, V39, P2047, DOI 10.1093/eurheartj/ehy077
   Goldsmith RL, 1997, AM J CARDIOL, V80, P1101, DOI 10.1016/S0002-9149(97)00616-4
   GOSEKI Y, 1994, AM J CARDIOL, V73, P845, DOI 10.1016/0002-9149(94)90807-9
   Goykhman P, 2012, CARDIOVASC DIAGN THE, V2, P268, DOI 10.3978/j.issn.2223-3652.2012.10.02
   Grodzinsky A, 2015, EUR HEART J-QUAL CAR, V1, P92, DOI 10.1093/ehjqcco/qcv014
   Gulati M, 2009, ARCH INTERN MED, V169, P843, DOI 10.1001/archinternmed.2009.50
   Handberg EM, 2021, AM HEART J, V237, P90, DOI 10.1016/j.ahj.2021.03.011
   Heidenreich PA, 1999, JAMA-J AM MED ASSOC, V281, P1927, DOI 10.1001/jama.281.20.1927
   Henneman MM, 2008, J NUCL CARDIOL, V15, P442, DOI 10.1016/j.nuclcard.2008.02.023
   Jacobson AF, 2010, J AM COLL CARDIOL, V55, P2212, DOI 10.1016/j.jacc.2010.01.014
   Jalnapurkar Sawan, 2017, J Radiol Nurs, V36, P180, DOI 10.1016/j.jradnu.2017.04.016
   Jansen Tea, 2022, J AM COLL CARDIOL IM, DOI [10.1016/j.cmg.2022.03.012, DOI 10.1016/J.CMG.2022.03.012]
   Jespersen L, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0093170
   Jespersen L, 2013, CLIN RES CARDIOL, V102, P571, DOI 10.1007/s00392-013-0568-z
   Jespersen L, 2012, EUR HEART J, V33, P734, DOI 10.1093/eurheartj/ehr331
   Jiang W, 2013, JAMA-J AM MED ASSOC, V309, P2139, DOI 10.1001/jama.2013.5566
   Johnson BD, 2004, CIRCULATION, V109, P2993, DOI 10.1161/01.CIR.0000130642.79868.B2
   Jones E, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0243213
   Jonsson G, 2007, J CARDIOVASC PHARM, V49, P27, DOI 10.1097/FJC.0b013e31802bdd8c
   Kalinowski L, 2003, CIRCULATION, V107, P2747, DOI 10.1161/01.CIR.0000066912.58385.DE
   KASKI JC, 1995, J AM COLL CARDIOL, V25, P807, DOI 10.1016/0735-1097(94)00507-M
   Kayaalti F, 2010, HEART VESSELS, V25, P92, DOI 10.1007/s00380-009-1170-1
   KEMP HG, 1973, AM J CARDIOL, V32, P375, DOI 10.1016/S0002-9149(73)80150-X
   Kern MJ, 2000, CIRCULATION, V101, P1344, DOI 10.1161/01.CIR.101.11.1344
   Khuddus MA, 2010, J INTERV CARDIOL, V23, P511, DOI 10.1111/j.1540-8183.2010.00598.x
   Knuuti J, 2020, EUR HEART J, V41, P407, DOI 10.1093/eurheartj/ehz425
   Krishna MB, 2017, CELL PHYSIOL BIOCHEM, V43, P1880, DOI 10.1159/000484107
   Kronhaus KD, 2009, INT J CARDIOL, V135, P256, DOI 10.1016/j.ijcard.2008.03.022
   Kumar S, 2021, CATHETER CARDIO INTE, V98, P827, DOI 10.1002/ccd.29237
   Kume T, 2005, CIRC J, V69, P934, DOI 10.1253/circj.69.934
   Lanza GA, 2005, EUR HEART J, V26, P983, DOI 10.1093/eurheartj/ehi089
   Lavi S, 2007, AM J PHYSIOL-REG I, V292, pR788, DOI 10.1152/ajpregu.00352.2006
   Lee JM, 2016, J AM COLL CARDIOL, V67, P1158, DOI 10.1016/j.jacc.2015.12.053
   Lee JF, 2016, HEART, V102, P278, DOI 10.1136/heartjnl-2015-308403
   Lerman A, 1998, CIRCULATION, V97, P2123, DOI 10.1161/01.CIR.97.21.2123
   Libby P, 2021, CARDIOVASC RES, V117, P2525, DOI 10.1093/cvr/cvab303
   Lindahl B, 2017, CIRCULATION, V135, P1481, DOI 10.1161/CIRCULATIONAHA.116.026336
   Lyon AR, 2021, J AM COLL CARDIOL, V77, P902, DOI 10.1016/j.jacc.2020.10.060
   Maddox TM, 2014, JAMA-J AM MED ASSOC, V312, P1754, DOI 10.1001/jama.2014.14681
   Maddox TM, 2010, CIRC-CARDIOVASC QUAL, V3, P632, DOI 10.1161/CIRCOUTCOMES.109.906214
   Maréchaux S, 2016, J CARD FAIL, V22, P3, DOI 10.1016/j.cardfail.2015.09.003
   Mathew RC, 2020, JACC-CARDIOVASC IMAG, V13, P1577, DOI 10.1016/j.jcmg.2019.09.006
   Mehta PK, 2022, REV CARDIOVASC MED, V23, DOI 10.31083/j.rcm2308288
   Mehta PK, 2022, INT J CARDIOL, V348, P1, DOI 10.1016/j.ijcard.2021.12.013
   Mehta PK, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.117.005501
   Mehta PK, 2018, INT J CARDIOL, V251, P8, DOI 10.1016/j.ijcard.2017.10.061
   Mehta PK, 2016, J AM COLL CARDIOL, V67, P1619, DOI 10.1016/S0735-1097(16)31620-5
   Mekonnen G, 2015, ATHEROSCLEROSIS, V239, P55, DOI 10.1016/j.atherosclerosis.2014.12.025
   Melikian N, 2008, PROG CARDIOVASC DIS, V50, P294, DOI 10.1016/j.pcad.2007.01.003
   Merz CNB, 2020, CARDIOVASC RES, V116, P856, DOI 10.1093/cvr/cvaa006
   Merz CNB, 2017, CIRCULATION, V135, P1075, DOI 10.1161/CIRCULATIONAHA.116.024534
   Mohammed SF, 2015, CIRCULATION, V131, P550, DOI 10.1161/CIRCULATIONAHA.114.009625
   Mohri M, 2003, J AM COLL CARDIOL, V41, P15, DOI 10.1016/S0735-1097(02)02632-3
   Mortara A, 2000, J AM COLL CARDIOL, V36, P1612, DOI 10.1016/S0735-1097(00)00900-1
   Mosca L, 2011, J AM COLL CARDIOL, V57, P1404, DOI [10.1016/j.jacc.2011.02.005, 10.1161/CIR.0b013e31820faaf8]
   Murthy VL, 2014, CIRCULATION, V129, P2518, DOI 10.1161/CIRCULATIONAHA.113.008507
   Mygind ND, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.115.003064
   Nakajima T, 2003, JPN HEART J, V44, P963, DOI 10.1536/jhj.44.963
   Nalbantgil, 1999, Int J Angiol, V8, P40, DOI 10.1007/BF01616842
   Ng MKC, 2006, CIRCULATION, V113, P2054, DOI 10.1161/CIRCULATIONAHA.105.603522
   Nishi T, 2019, CIRC-CARDIOVASC INTE, V12, DOI 10.1161/CIRCINTERVENTIONS.119.007889
   NISHIMURA RA, 1995, J AM COLL CARDIOL, V26, P41, DOI 10.1016/0735-1097(95)00142-M
   Nordenskjöld AM, 2021, AM HEART J, V231, P96, DOI 10.1016/j.ahj.2020.10.059
   Ong P, 2018, INT J CARDIOL, V250, P16, DOI 10.1016/j.ijcard.2017.08.068
   Ong P, 2015, EUR HEART J-CARD PHA, V1, P65, DOI 10.1093/ehjcvp/pvu020
   Ong P, 2014, CLIN CARDIOL, V37, P462, DOI 10.1002/clc.22282
   Parsyan A, 2012, CAN J CARDIOL, V28, pS3, DOI 10.1016/j.cjca.2011.09.017
   Pasupathy S, 2021, CIRC-CARDIOVASC QUAL, V14, DOI 10.1161/CIRCOUTCOMES.121.007880
   Pasupathy S, 2017, CIRCULATION, V135, P1490, DOI 10.1161/CIRCULATIONAHA.117.027666
   Pasupathy S, 2015, CIRCULATION, V131, P861, DOI 10.1161/CIRCULATIONAHA.114.011201
   Pepine CJ, 2015, J AM COLL CARDIOL, V66, P1918, DOI 10.1016/j.jacc.2015.08.876
   Pepine CJ, 2010, J AM COLL CARDIOL, V55, P2825, DOI 10.1016/j.jacc.2010.01.054
   Poole-Wilson PA, 2003, LANCET, V362, P7, DOI 10.1016/S0140-6736(03)13800-7
   Prasad A, 2009, NAT REV CARDIOL, V6, P430, DOI 10.1038/nrcardio.2009.51
   Radico F, 2018, EUR HEART J, V39, P2135, DOI 10.1093/eurheartj/ehy185
   Raggi P, 2018, ATHEROSCLEROSIS, V276, P98, DOI 10.1016/j.atherosclerosis.2018.07.014
   Rahman H, 2021, JACC-CARDIOVASC IMAG, V14, P978, DOI 10.1016/j.jcmg.2020.10.015
   Rai B, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10051137
   Recio-Mayoral A, 2013, JACC-CARDIOVASC IMAG, V6, P660, DOI 10.1016/j.jcmg.2012.12.011
   Redfield MM, 2016, NEW ENGL J MED, V375, P1868, DOI 10.1056/NEJMcp1511175
   Reynolds HR, 2021, CIRCULATION, V143, P624, DOI 10.1161/CIRCULATIONAHA.120.052008
   Rogers G E, 1977, Adv Exp Med Biol, V86A, P283
   Roy R, 2020, INT J CARDIOL, V316, P1, DOI 10.1016/j.ijcard.2020.04.030
   Rush CJ, 2021, JAMA CARDIOL, V6, P1130, DOI 10.1001/jamacardio.2021.1825
   Russo G, 2013, CARDIOVASC DRUG THER, V27, P229, DOI 10.1007/s10557-013-6439-z
   Safdar B, 2018, J AM HEART ASSOC, V7, DOI 10.1161/JAHA.118.009174
   Samuel TJ, 2021, INT J CARDIOL, V331, P1, DOI 10.1016/j.ijcard.2021.01.064
   Sara JD, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0833-1
   Savarese Gianluigi, 2017, Card Fail Rev, V3, P7, DOI 10.15420/cfr.2016:25:2
   Schumann CL, 2021, JACC-CARDIOVASC IMAG, V14, P1369, DOI 10.1016/j.jcmg.2021.01.041
   Sciammarella M, 2015, J NUCL CARDIOL, V22, P804, DOI 10.1007/s12350-015-0202-8
   Sezai A, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0877-2
   Sezer M, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.116.003995
   Shah SJ, 2018, EUR HEART J, V39, P3439, DOI 10.1093/eurheartj/ehy531
   Sharkey SW, 2014, CIRC J, V78, P2119, DOI 10.1253/circj.CJ-14-0770
   Shaw JL, 2018, INT J CARDIOL, V270, P48, DOI 10.1016/j.ijcard.2018.06.086
   Shaw LJ, 2006, CIRCULATION, V114, P894, DOI 10.1161/CIRCULATIONAHA.105.609990
   Shigiyama F, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-017-0564-0
   Shimokawa H, 2021, EUR HEART J, V42, P4592, DOI 10.1093/eurheartj/ehab282
   Skalidis EI, 2011, ATHEROSCLEROSIS, V215, P160, DOI 10.1016/j.atherosclerosis.2010.11.035
   Smilowitz NR, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0255462
   Srivaratharajah K, 2016, CIRC-HEART FAIL, V9, DOI 10.1161/CIRCHEARTFAILURE.115.002562
   Sugioka K, 2005, J AM COLL CARDIOL, V45, P318, DOI 10.1016/j.jacc.2004.10.019
   Sutsch G, 1995, INT J CARDIOL, V52, P135, DOI 10.1016/0167-5273(95)02458-9
   Szot W, 2015, ANN AGR ENV MED, V22, P390, DOI 10.5604/12321966.1152100
   Tagliamonte E, 2015, ADV THER, V32, P757, DOI 10.1007/s12325-015-0237-x
   Talbott EO, 2000, ARTERIOSCL THROM VAS, V20, P2414, DOI 10.1161/01.ATV.20.11.2414
   Tamis-Holland JE, 2019, CIRCULATION, V139, pE891, DOI 10.1161/CIR.0000000000000670
   Tanaka A, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-017-0532-8
   Taqueti VR, 2018, J AM COLL CARDIOL, V72, P2625, DOI 10.1016/j.jacc.2018.09.042
   Taqueti VR, 2018, EUR HEART J, V39, P840, DOI 10.1093/eurheartj/ehx721
   Taqueti VR, 2015, CIRCULATION, V131, P19, DOI 10.1161/CIRCULATIONAHA.114.011939
   Taube A, 2012, AM J PHYSIOL-HEART C, V302, pH2148, DOI 10.1152/ajpheart.00907.2011
   Thomson LEJ, 2015, CIRC-CARDIOVASC IMAG, V8, DOI 10.1161/CIRCIMAGING.114.002481
   Tochiya M, 2020, J DIABETES INVEST, V11, P400, DOI 10.1111/jdi.13122
   Tona F, 2014, NUTR METAB CARDIOVAS, V24, P447, DOI 10.1016/j.numecd.2013.09.021
   Travin MI, 2019, J NUCL CARDIOL, V26, P1434, DOI 10.1007/s12350-018-1394-5
   Urano H, 2001, J AM COLL CARDIOL, V37, P93, DOI 10.1016/S0735-1097(00)01095-0
   Vaccaro A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0093278
   van de Hoef TP, 2013, CIRC-CARDIOVASC INTE, V6, P329, DOI 10.1161/CIRCINTERVENTIONS.113.000378
   van Empel VPM, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.114.001293
   van Rosendael AR, 2020, EUR HEART J-CARD IMG, V21, P479, DOI 10.1093/ehjci/jez322
   Villano A, 2013, AM J CARDIOL, V112, P8, DOI 10.1016/j.amjcard.2013.02.045
   von Mering GO, 2004, CIRCULATION, V109, P722, DOI 10.1161/01.CIR.0000115525.92645.16
   von Scholten BJ, 2016, DIABETES, V65, P3129, DOI 10.2337/db16-0437
   Vyssoulis GP, 2004, AM J HYPERTENS, V17, P582, DOI 10.1016/j.amjhyper.2004.03.668
   Wang ZJ, 2017, MAYO CLIN PROC, V92, P329, DOI 10.1016/j.mayocp.2016.11.016
   Weber BN, 2021, J AM HEART ASSOC, V10, DOI 10.1161/JAHA.120.018555
   Wei J, 2018, EUR HEART J, V39, P3451, DOI 10.1093/eurheartj/ehy558
   Wei J, 2012, JACC-CARDIOVASC INTE, V5, P646, DOI 10.1016/j.jcin.2012.01.023
   Widmer RJ, 2019, EUROINTERVENTION, V14, P1694, DOI 10.4244/EIJ-D-18-00982
   WIENER L, 1966, AM J MED SCI, V252, P289, DOI 10.1097/00000441-196609000-00007
   Yun AJ, 2005, MED HYPOTHESES, V65, P962, DOI 10.1016/j.mehy.2005.02.009
NR 189
TC 55
Z9 58
U1 3
U2 12
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD DEC
PY 2022
VL 363
BP 8
EP 21
DI 10.1016/j.atherosclerosis.2022.11.009
EA NOV 2022
PG 14
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 7J2XP
UT WOS:000904447700002
PM 36423427
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lupoli, R
   Calcaterra, I
   Ambrosino, P
   Giacco, R
   Vitale, M
   Della Pepa, G
   Rivellese, AA
   Iannuzzo, G
   Bozzetto, L
   Di Minno, M
AF Lupoli, Roberta
   Calcaterra, Ilenia
   Ambrosino, Pasquale
   Giacco, Rosalba
   Vitale, Marilena
   Della Pepa, Giuseppe
   Rivellese, Angela Albarosa
   Iannuzzo, Gabriella
   Bozzetto, Lutgarda
   Di Minno, Matteo
TI Effects of Mediterranean Diet on Endothelial Reactivity in Individuals
   with High Cardiometabolic Risk: A Randomized Controlled Parallel-Group
   Preliminary Trial
SO BIOMEDICINES
LA English
DT Article
DE mediterranean diet; endothelial function; inflammation; oxidative
   stress; cardiovascular risk; cardiovascular disability; chronic disease;
   exercise; lifestyle risk reduction; outcome
ID OLIVE OIL; INSULIN-RESISTANCE; BRACHIAL-ARTERY; DYSFUNCTION;
   INFLAMMATION; REHABILITATION; ANTIOXIDANTS; POLYPHENOLS; IMPROVEMENT;
   GUIDELINES
AB Background: Endothelial dysfunction is recognized as an early modification involved in the pathogenesis of vascular diseases. Evidence suggests that the Mediterranean Diet (MD) is associated with endothelial function improvement and, in turn, plays an important role in atherosclerosis development and progression. Objectives: To evaluate both acute and sustained effects of the MD on endothelial function in patients with high cardiometabolic risk. Methods: A total of 25 subjects were randomly assigned to either the MD group or the Control Diet (CD) group according to a single-blind, parallel-group study design. Endothelial function was evaluated through non-invasive flow-mediated dilation (FMD) measurements at baseline (T0) and after 8 weeks (Tw8) of the MD or CD intervention, under both 12 h fast condition (fasting) and 2 h post-meal resembling the assigned diet (2 h). Assessments were conducted by a blinded sonographer. Results: FMD at T0-fasting was similar between MD and CD groups (6.11% +/- 0.67 vs. 7.90% +/- 1.65; p = 0.266). A significant difference in FMD between MD and CD groups was observed at T0-2h (12.14% +/- 1.93 vs. 4.01% +/- 1.03; p = 0.004), T8w-fasting (9.76% +/- 1.18 vs. 5.03% +/- 0.89; p = 0.008), and T8w-2h (8.99% +/- 1.22 vs. 3.86% +/- 0.52; p = 0.003). Oral glucose insulin sensitivity (OGIS) at T0 correlated with FMD percent changes from T0-fasting to T0-2h (r = 0.414, p = 0.044). After adjusting for age, gender, and OGIS, MD was an independent predictor of percent changes in FMD from T0-fasting to T0-2h (beta: -0.582, p = 0.003), from T0-fasting to T8w-fasting (beta: -0.498, p = 0.013), and from T0-fasting to T8w-2h (beta: -0.479, p = 0.018). Conclusions: Adherence to the MD may improve endothelial function in both the short- and medium-term among patients at high cardiometabolic risk.
C1 [Lupoli, Roberta] Univ Naples Federico II, Dept Mol Med & Med Biotechnol, I-80131 Naples, Italy.
   [Calcaterra, Ilenia; Vitale, Marilena; Della Pepa, Giuseppe; Rivellese, Angela Albarosa; Iannuzzo, Gabriella; Bozzetto, Lutgarda; Di Minno, Matteo] Univ Naples Federico II, Dept Clin Med & Surg, I-80131 Naples, Italy.
   [Ambrosino, Pasquale] Ist Clin Sci Maugeri IRCCS, Sci Directorate Telese Terme Inst, I-82037 Telese Terme, Italy.
   [Giacco, Rosalba] CNR, Inst Food Sci, I-83100 Avellino, Italy.
C3 University of Naples Federico II; University of Naples Federico II;
   Consiglio Nazionale delle Ricerche (CNR); Istituto di Scienze dell'
   Alimentazione (ISA-CNR)
RP Ambrosino, P (corresponding author), Ist Clin Sci Maugeri IRCCS, Sci Directorate Telese Terme Inst, I-82037 Telese Terme, Italy.
EM roberta.lupoli@unina.it; ilenialorenza.calcaterra@unina.it;
   pasquale.ambrosino@icsmaugeri.it; rosalba.giacco@isa.cnr;
   marilena.vitale@unina.it; giuseppe.dellapepa@unina.it;
   rivelles@unina.it; gabriella.iannuzzo@unina.it;
   lutgarda.bozzetto@unina.it; matteo.diminno@unina.it
RI Bozzetto, Lutgarda/E-6271-2012; iannuzzo, Gabriella/ABH-3527-2020; Della
   Pepa, Giuseppe/AAK-5488-2020; Calcaterra, Ilenia/AAH-6666-2020; Vitale,
   Marilena/J-1457-2014; Ambrosino, Pasquale/AAD-1934-2020; Di Minno,
   Matteo/D-5141-2012
OI Calcaterra, Ilenia/0000-0001-8077-2809; Vitale,
   Marilena/0000-0001-9951-4674; Ambrosino, Pasquale/0000-0002-9398-0428;
   Di Minno, Matteo/0000-0001-8059-3819
CR Ambrosino P, 2023, EUR J INTERN MED, V116, P96, DOI 10.1016/j.ejim.2023.06.015
   Ambrosino P, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10112757
   Ambrosino P, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9060614
   Arpón A, 2016, J PHYSIOL BIOCHEM, V73, P445, DOI 10.1007/s13105-017-0552-6
   Awada M, 2024, CORONARY ARTERY DIS, V35, P8, DOI 10.1097/MCA.0000000000001295
   Baynham R, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1275708
   BONANOME A, 1992, ARTERIOSCLER THROMB, V12, P529, DOI 10.1161/01.ATV.12.4.529
   Bonetti PO, 2003, ARTERIOSCL THROM VAS, V23, P168, DOI 10.1161/01.ATV.0000051384.43104.FC
   Cicero AFG, 2017, NUTR METAB, V14, DOI 10.1186/s12986-017-0214-2
   Corretti MC, 2002, J AM COLL CARDIOL, V39, P257, DOI 10.1016/S0735-1097(01)01746-6
   D'Alessandro A, 2018, INT J FOOD SCI NUTR, V69, P647, DOI 10.1080/09637486.2017.1417978
   Daiber A, 2017, BRIT J PHARMACOL, V174, P1591, DOI 10.1111/bph.13517
   de Lorgeril M, 1999, CIRCULATION, V99, P779, DOI 10.1161/01.CIR.99.6.779
   De Luca L, 2020, EXPERT REV CARDIOVAS, V18, P881, DOI 10.1080/14779072.2020.1833719
   Deanfield JE, 2007, CIRCULATION, V115, P1285, DOI 10.1161/CIRCULATIONAHA.106.652859
   Estruch R, 2018, NEW ENGL J MED, V378, DOI [10.1056/NEJMoa1800389, 10.1056/NEJMoa1200303, 10.1056/nejmoa1800389]
   Estruch R, 2010, P NUTR SOC, V69, P333, DOI 10.1017/S0029665110001539
   Fatima K, 2023, IRISH J MED SCI, V192, P105, DOI 10.1007/s11845-022-02944-9
   Feijóo-Bandín S, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21207711
   Fffff K.F., 2010, FFFBMC MED, V8, DOI [10.1186/1741-7015-8-18ffff, DOI 10.1186/1741-7015-8-18FFFF]
   Fitó M, 2007, ARCH INTERN MED, V167, P1195, DOI 10.1001/archinte.167.11.1195
   Galbete C, 2018, EUR J EPIDEMIOL, V33, P909, DOI 10.1007/s10654-018-0427-3
   Gielen S, 2005, EUR J CARDIOV PREV R, V12, P393, DOI 10.1097/01.hjr.0000174824.94892.43
   Green DJ, 2011, HYPERTENSION, V57, P363, DOI 10.1161/HYPERTENSIONAHA.110.167015
   Greyling A, 2016, ATHEROSCLEROSIS, V248, P196, DOI 10.1016/j.atherosclerosis.2016.03.011
   Hsu CY, 2024, PHYTOTHER RES, V38, P1358, DOI 10.1002/ptr.8109
   Inaba Y, 2010, INT J CARDIOVAS IMAG, V26, P631, DOI 10.1007/s10554-010-9616-1
   Karatzi K, 2008, J AM COLL NUTR, V27, P448, DOI 10.1080/07315724.2008.10719724
   Khandouzi N, 2023, CORONARY ARTERY DIS, V34, P332, DOI 10.1097/MCA.0000000000001259
   Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213
   Kondo K, 2014, METABOLISM, V63, P930, DOI 10.1016/j.metabol.2014.04.005
   Lacroix S, 2016, APPL PHYSIOL NUTR ME, V41, P888, DOI 10.1139/apnm-2015-0490
   Lacroix S, 2012, NUTR RES REV, V25, P288, DOI 10.1017/S0954422412000182
   Lopez-Garcia E, 2004, AM J CLIN NUTR, V80, P1029, DOI 10.1093/ajcn/80.4.1029
   Lteif AA, 2005, CIRCULATION, V112, P32, DOI 10.1161/CIRCULATIONAHA.104.520130
   Medina-Remón A, 2015, NUTR METAB CARDIOVAS, V25, P60, DOI 10.1016/j.numecd.2014.09.001
   Mena MP, 2009, AM J CLIN NUTR, V89, P248, DOI 10.3945/ajcn.2008.26094
   Mlakar P, 2015, IJC HEART VASC, V7, P40, DOI 10.1016/j.ijcha.2015.02.003
   Munir KM, 2013, AM J PHYSIOL-ENDOC M, V305, pE679, DOI 10.1152/ajpendo.00377.2013
   Perez-Martinez P, 2007, ATHEROSCLEROSIS, V194, pE141, DOI 10.1016/j.atherosclerosis.2006.11.033
   Phadnis MA, 2019, CONT CLIN TRIAL COMM, V15, DOI 10.1016/j.conctc.2019.100360
   Ras RT, 2013, INT J CARDIOL, V168, P344, DOI 10.1016/j.ijcard.2012.09.047
   Rees K, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009825.pub3
   Rigoni S, 2021, J ORTHOP, V25, P237, DOI 10.1016/j.jor.2021.05.016
   Schwingshackl L, 2015, NUTRIENTS, V7, P7651, DOI 10.3390/nu7095356
   Shannon OM, 2020, J NUTR, V150, P1151, DOI 10.1093/jn/nxaa002
   Shannon OM, 2018, J GERONTOL A-BIOL, V73, P902, DOI 10.1093/gerona/gly087
   Sofi F, 2010, AM J CLIN NUTR, V92, P1189, DOI 10.3945/ajcn.2010.29673
   Veglia F, 2014, HYPERTENSION, V64, P1328, DOI 10.1161/HYPERTENSIONAHA.114.03608
   Versari D, 2009, DIABETES CARE, V32, pS314, DOI 10.2337/dc09-S330
   Vitale M, 2021, CLIN NUTR, V40, P428, DOI 10.1016/j.clnu.2020.05.025
   Vogel RA, 2000, J AM COLL CARDIOL, V36, P1455, DOI 10.1016/S0735-1097(00)00896-2
   Vogel RA, 1997, AM J CARDIOL, V79, P350, DOI 10.1016/S0002-9149(96)00760-6
   Xiao YJ, 2018, CLIN NUTR, V37, P831, DOI 10.1016/j.clnu.2017.04.011
   Yubero-Serrano EM, 2020, PLOS MED, V17, DOI 10.1371/journal.pmed.1003282
NR 55
TC 1
Z9 1
U1 2
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD NOV
PY 2024
VL 12
IS 11
AR 2595
DI 10.3390/biomedicines12112595
PG 13
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA N8K9F
UT WOS:001366767900001
PM 39595161
OA gold
DA 2025-06-11
ER

PT J
AU da Silva, MM
   Gomes, MFP
   de Moura, EDC
   Veras, MM
   Kubota, MC
   Takano, AP
   dos Santos, ACC
   Jose, CGD
   Souza, GAD
   Cardoso, NM
   Estadella, D
   Lambertucci, RH
   Medeiros, A
AF da Silva, Monique Marques
   Pereira Gomes, Moises Felipe
   Carvalho de Moura, Elizabeth de Orleans
   Veras, Mariana Matera
   Kubota, Melina Chiemi
   Takano, Ana Paula
   Cardoso dos Santos, Ana Carolina
   dos Reis Jose, Carolina Goncalves
   da Silva Souza, Graziele Aparecida
   Cardoso, Naiara Magalhaes
   Estadella, Debora
   Lambertucci, Rafael Herling
   Medeiros, Alessandra
TI Aerobic exercise training combined or not with okra consumption as a
   strategy to prevent kidney changes caused by metabolic syndrome in
   Zucker rats
SO PLOS ONE
LA English
DT Article
ID ABELMOSCHUS-ESCULENTUS; OXIDATIVE STRESS; RENAL FIBROSIS; DISEASE;
   FATTY; OBESE; INFLAMMATION; NEPHROPATHY; SUPEROXIDE; RECEPTOR
AB The complications of Metabolic Syndrome (MetS) include kidney disease, and most dialysis patients are diagnosed with MetS. The benefit of exercise training (ET) for MetS treatment is already well defined in the literature, but the antidiabetic and antihyperlipidemic benefits of okra (O) have been discovered only recently. The aim of this study was to evaluate the effects of O and/or ET supplementation on renal function and histology; serum urea and creatinine value; inflammation (IL-6, IL-10, TNF-alpha) and oxidative stress in renal tissue. For this, 32 Zucker rats (fa/fa) were randomly separated into four groups of 8 animals each: Metabolic Syndrome (MetS), MetS + Okra (MetS + O), MetS + Exercise Training (MetS + ET), and MetS + Exercise Training and Okra (MetS + ET + O), and 8 Zucker lean (fa/+) rats comprised the Control group (CTL). Okra was administered by orogastric gavage 2x/day (morning and night, 100 mg/kg) and ET performed on the treadmill, at moderate intensity, 1h/day, 5x/week for 6 weeks. Although the renal function was not altered, the animals with MetS showed greater fibrotic deposition accompanied by a worse stage of renal injury, in addition to increased kidney weight. Although all interventions were beneficial in reducing fibrosis, only ET combined with O was able to improve the degree of renal tissue impairment. ET improved the anti-inflammatory status and reduced nitrite levels, but the combination of ET and O was more beneficial as regards catalase activity. Okra consumption alone did not promote changes in inflammatory cytokines and oxidative stress in the kidney. In conclusion, ET combined or not with O seems to be beneficial in preventing the progression of renal disease when renal function is not yet altered.
C1 [da Silva, Monique Marques; Pereira Gomes, Moises Felipe; Carvalho de Moura, Elizabeth de Orleans; Kubota, Melina Chiemi; Cardoso dos Santos, Ana Carolina; dos Reis Jose, Carolina Goncalves; da Silva Souza, Graziele Aparecida; Cardoso, Naiara Magalhaes; Estadella, Debora; Lambertucci, Rafael Herling; Medeiros, Alessandra] Univ Fed Sao Paulo, Interdisciplinary Grad Program Hlth Sci, Santos, SP, Brazil.
   [Veras, Mariana Matera; Takano, Ana Paula] Univ Sao Paulo, Dept Pathol, Lab Environm Air Pollut, Sch Med, Sao Paulo, Brazil.
   [Estadella, Debora; Lambertucci, Rafael Herling; Medeiros, Alessandra] Univ Fed Sao Paulo, Biosci Dept, Santos, SP, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade de Sao Paulo;
   Universidade Federal de Sao Paulo (UNIFESP)
RP Medeiros, A (corresponding author), Univ Fed Sao Paulo, Interdisciplinary Grad Program Hlth Sci, Santos, SP, Brazil.; Medeiros, A (corresponding author), Univ Fed Sao Paulo, Biosci Dept, Santos, SP, Brazil.
EM a.medeiros@unifesp.br
RI Takano, Ana/AAG-6514-2021; Gomes, Moisés/AGB-6281-2022; Lambertucci,
   Rafael/C-6975-2012; Estadella, Debora/G-5817-2012; Medeiros,
   Alessandra/E-8132-2012; VERAS, MARIANA/D-8575-2012
OI Marques da Silva, Monique/0000-0002-3376-6833; Felipe Pereira Gomes,
   Moises/0000-0003-3948-0497; Medeiros, Alessandra/0000-0002-7962-7185;
   VERAS, MARIANA/0000-0002-8363-4329; Cremasco Takano, Ana
   Paula/0000-0002-5057-1560
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [2015/19893-0]; Conselho Nacional de Desenvolvimento e Tecnologico
   (CNPq) [305190/2018-0]; Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior Brasil (CAPES) [001]
FX This study was funded by Fundacao de Amparo a Pesquisa do Estado de Sao
   Paulo (FAPESP #2015/19893-0) and Conselho Nacional de Desenvolvimento e
   Tecnologico (CNPq #305190/2018-0) in the form of grants to AM. This
   study was also funded by Coordenacao de Aperfeicoamento de Pessoal de Ni
   ' vel Superior Brasil (CAPES) -Finance Code 001 awarded to MMS.
CR AEBI H, 1984, METHOD ENZYMOL, V105, P121
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   de Artiñano AA, 2009, BRIT J NUTR, V102, P1246, DOI 10.1017/S0007114509990729
   Almomen SMK, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040345
   [Anonymous], 2005, Arquivos Brasileiros de Cardiologia, V84, P4, DOI 10.1590/s0066-782x2005000700001
   Asgharzadeh F, 2018, ARYA ATHEROSCLER, V14, P71, DOI 10.22122/arya.v14i2.1550
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Brum PC., 2004, Rev Paul Educ Fis, V18, P21
   Carlström M, 2021, NAT REV NEPHROL, V17, P575, DOI 10.1038/s41581-021-00429-z
   Cohen J., 1988, STAT POWER ANAL BEHA, DOI [10.4324/9780203771587, DOI 10.4324/9780203771587]
   DING AH, 1988, J IMMUNOL, V141, P2407
   Eknoyan G, 2002, AM J KIDNEY DIS, V39, pS14, DOI 10.1053/ajkd.2002.30939
   Ellulu MS, 2017, ARCH MED SCI, V13, P851, DOI 10.5114/aoms.2016.58928
   Erel O, 2004, CLIN BIOCHEM, V37, P277, DOI 10.1016/j.clinbiochem.2003.11.015
   Erel O, 2005, CLIN BIOCHEM, V38, P1103, DOI 10.1016/j.clinbiochem.2005.08.008
   Fiuza-Luces C, 2018, NAT REV CARDIOL, V15, P731, DOI 10.1038/s41569-018-0065-1
   FLOHE L, 1984, METHOD ENZYMOL, V105, P114
   FLOHE L, 1984, METHOD ENZYMOL, V105, P93
   Frazier KS, 2012, TOXICOL PATHOL, V40, P14, DOI 10.1177/0192623312438736
   Neto JCGL, 2017, REV BRAS ENFERM, V70, P265
   Gluba A, 2013, INT J CARDIOL, V164, P141, DOI 10.1016/j.ijcard.2012.01.013
   Gois PHF, 2016, FREE RADICAL BIO MED, V101, P176, DOI 10.1016/j.freeradbiomed.2016.10.012
   Hager MR, 2017, REV ENDOCR METAB DIS, V18, P29, DOI 10.1007/s11154-016-9402-z
   He L, 2011, EVID-BASED COMPL ALT, V2011, P1, DOI 10.1093/ecam/nep095
   Ikizler TA, 2018, J AM SOC NEPHROL, V29, P250, DOI 10.1681/ASN.2017010020
   Iseki K, 2008, J NEPHROL, V21, P305
   JANERO DR, 1990, FREE RADICAL BIO MED, V9, P515, DOI 10.1016/0891-5849(90)90131-2
   Li L, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0142884
   Li N, 2021, PHYTOTHER RES, V35, P198, DOI 10.1002/ptr.6818
   Li YH, 2008, DIABETES-METAB RES, V24, P498, DOI 10.1002/dmrr.874
   Liang G, 2018, KIDNEY INT, V93, P95, DOI 10.1016/j.kint.2017.05.013
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   Mella Pinheiro A., 2012, EFEITOS EXERC CIO OS
   Mikolasevic I, 2017, INT J NEPHROL RENOV, V10, P35, DOI 10.2147/IJNRD.S101808
   Mishra Neetu, 2016, Journal of Dietary Supplements, V13, P634, DOI 10.3109/19390211.2016.1164787
   Moradi A, 2020, PHYTOTHER RES, V34, P3325, DOI 10.1002/ptr.6782
   Moraes-Silva IC, 2010, CLIN EXP PHARMACOL P, V37, pe114, DOI 10.1111/j.1440-1681.2009.05333.x
   Muhammad AB, 2011, AM J PHYSIOL-RENAL, V300, pF98, DOI 10.1152/ajprenal.00386.2010
   Müller S, 2002, DIABETOLOGIA, V45, P805, DOI 10.1007/s00125-002-0829-2
   Nakazone MA, 2007, REV ASSOC MED BRAS, V53, P407, DOI 10.1590/S0104-42302007000500016
   Peng CH, 2019, J FOOD DRUG ANAL, V27, P135, DOI 10.1016/j.jfda.2018.07.004
   Prasad G V Ramesh, 2014, World J Nephrol, V3, P210, DOI 10.5527/wjn.v3.i4.210
   Rafikova O, 2008, METABOLISM, V57, P1434, DOI 10.1016/j.metabol.2008.05.014
   Raikou VD, 2019, DIAB MET SYND CLIN R, V13, P1041, DOI 10.1016/j.dsx.2019.01.017
   Raikou Vaia D, 2018, Diseases, V6, DOI 10.3390/diseases6010012
   Sabitha V, 2011, J PHARM BIOALLIED SC, V3, P397, DOI 10.4103/0975-7406.84447
   Sabitha Vijayakumar, 2012, J Ayurveda Integr Med, V3, P188, DOI 10.4103/0975-9476.104432
   Sallam N, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/7239639
   Silva I., 2010, EFEITOS TREINAMENTO
   Sivakumar S, 2010, CHEM-BIOL INTERACT, V188, P237, DOI 10.1016/j.cbi.2010.07.014
   Spoto B, 2016, AM J PHYSIOL-RENAL, V311, pF1087, DOI 10.1152/ajprenal.00340.2016
   Toblli JE, 2011, J HYPERTENS, V29, P1613, DOI 10.1097/HJH.0b013e328349064c
   Tofovic SP, 2007, RENAL FAILURE, V29, P891, DOI 10.1080/08860220701569846
   Upala S, 2018, INT J ENDOCRINOL MET, V16, DOI 10.5812/ijem.61201
   Watson AMD, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.00518
   Zhang X, 2017, TRANSL RES, V183, P14, DOI 10.1016/j.trsl.2016.12.004
   ZUCKER LM, 1961, J HERED, V52, P275, DOI 10.1093/oxfordjournals.jhered.a107093
NR 57
TC 1
Z9 1
U1 1
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PY 2022
VL 17
IS 6
AR e0269418
DI 10.1371/journal.pone.0269418
PG 21
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 3Y2OK
UT WOS:000843567600087
PM 35657982
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Du, FM
   Kuang, HY
   Duan, BH
   Liu, DN
   Yu, XY
AF Du, Fu-Man
   Kuang, Hong-Yu
   Duan, Bin-Hong
   Liu, Da-Na
   Yu, Xin-Yang
TI Effects of thyroid hormone and depression on common components of
   central obesity
SO JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
LA English
DT Article
DE Hypothyroidism; hyperthyroidism; depressive symptoms; obesity; body mass
   index; insulin resistance; total triglycerides; total cholesterol;
   low-density lipoprotein cholesterol
ID BODY-MASS INDEX; METABOLIC SYNDROME; SERUM THYROTROPIN; ASSOCIATIONS;
   ADOLESCENTS; CHILDREN
AB Objective We investigated the prevalence of abnormal thyroid function and depression in centrally obese participants, and to analyze the relationship of thyroid hormones and depression with components of central obesity. Methods We randomly selected 858 centrally obese participants and 500 non-obese controls in this study. For all participants, we measured serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), body mass index (BMI), waist-hip ratio (WHR), fasting blood glucose and insulin, homeostasis model assessment of insulin resistance (HOMA-IR), lipid concentrations, and blood pressure. Depression was assessed using the Center for Epidemiological Studies-Depression (CES-D) scale. Results Centrally obese participants had a higher prevalence of hypothyroidism and depression than non-obese controls. Serum FT4 levels negatively correlated with BMI and serum TSH levels and positively correlated with BMI, WHR, total triglycerides (TG), total cholesterol (TC), and low density lipoprotein cholesterol (LDL-C). After excluding participants with hypothyroidism and hyperthyroidism, serum FT4 levels showed negative correlation and serum TSH levels showed positive correlation with BMI in the remaining centrally obese participants. CES-D scores positively correlated with BMI. Conclusion We found high prevalences of hypothyroidism and depression among centrally obese participants. FT4 and TSH are important in weight regulation. Depression positively correlated with obesity.
C1 [Du, Fu-Man; Kuang, Hong-Yu; Liu, Da-Na; Yu, Xin-Yang] Harbin Med Univ, Affiliated Hosp 1, Dept Endocrinol, Harbin 150001, Heilongjiang, Peoples R China.
   [Du, Fu-Man; Duan, Bin-Hong] Heilongjiang Prov Hosp, Dept Endocrinol, Harbin, Heilongjiang, Peoples R China.
C3 Harbin Medical University
RP Kuang, HY (corresponding author), Harbin Med Univ, Affiliated Hosp 1, Dept Endocrinol, Harbin 150001, Heilongjiang, Peoples R China.
EM physiciankuang@outlook.com
RI yu, ellen/JSK-6301-2023
OI Du, Fuman/0000-0003-4961-4233
FU Health Commission of Heilongjiang Province [2016-504]
FX This study was supported by the Health Commission of Heilongjiang
   Province (Research project No. 2016-504).
CR [Anonymous], 2002, ZHONGHUA LIU XING BI, V23, P5, DOI DOI 10.3760/J.ISSN:0254-6450.2002.01.003
   Arroyo-Johnson C, 2016, GASTROENTEROL CLIN N, V45, P571, DOI 10.1016/j.gtc.2016.07.012
   Atlantis E, 2008, INT J OBESITY, V32, P881, DOI 10.1038/ijo.2008.54
   Aypak C, 2013, J PEDIATR ENDOCR MET, V26, P703, DOI 10.1515/jpem-2012-0384
   Bianco AC, 2013, LANCET DIABETES ENDO, V1, P250, DOI 10.1016/S2213-8587(13)70069-X
   Brent GA, 2012, J CLIN INVEST, V122, P3035, DOI 10.1172/JCI60047
   Cho WK, 2018, INT J ENDOCRINOL, V2018, DOI 10.1155/2018/6874395
   Dahl M, 2017, J CLIN RES PEDIATR E, V9, P8, DOI 10.4274/jcrpe.3319
   Dave DM, 2011, J MENT HEALTH POLICY, V14, P165
   Deshmukh V, 2018, INT J ENDOCRINOL, V2018, DOI 10.1155/2018/2930251
   Fox CS, 2008, ARCH INTERN MED, V168, P587, DOI 10.1001/archinte.168.6.587
   Fox CK, 2016, CLIN PEDIATR, V55, P1120, DOI 10.1177/0009922815615825
   Hamlaoui ML, 2018, DIABETES METAB SYND, V12, P1, DOI 10.1016/j.dsx.2017.08.001
   Ho RCM, 2008, INT J GERIATR PSYCH, V23, P401, DOI 10.1002/gps.1893
   HU W, 2017, PLOS ONE, V12, DOI DOI 10.1371/JOURNAL.0183934
   Ittermann T, 2013, THYROID, V23, P262, DOI 10.1089/thy.2012.0110
   Iwen KA, 2013, EUR THYROID J, V2, P83, DOI 10.1159/000351249
   Jantaratnotai N, 2017, OBES RES CLIN PRACT, V11, P1, DOI 10.1016/j.orcp.2016.07.003
   Le TN, 2016, THYROID, V26, P1441, DOI 10.1089/thy.2016.0055
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Mannan M, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0157240
   Mansur RB, 2015, NEUROSCI BIOBEHAV R, V52, P89, DOI 10.1016/j.neubiorev.2014.12.017
   McAninch EA, 2014, ANN NY ACAD SCI, V1311, P77, DOI 10.1111/nyas.12374
   Mehran L, 2017, HORM METAB RES, V49, P192, DOI 10.1055/s-0042-117279
   Mullur R, 2014, PHYSIOL REV, V94, P355, DOI 10.1152/physrev.00030.2013
   Ohmori Y, 2017, ASIA PAC J CLIN NUTR, V26, P130, DOI 10.6133/apjcn.112015.01
   Olvera RL, 2015, J CLIN PSYCHIAT, V76, pE1300, DOI 10.4088/JCP.14m09118
   Roever LS, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000001357
   Sieminska L, 2015, ENDOKRYNOL POL, V66, P394, DOI 10.5603/EP.2015.0049
   Staiano AE, 2016, OBESITY, V24, P1969, DOI 10.1002/oby.21567
   Wang J, 2009, BMJ OPEN, V7
   Wiltink J, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-223
   Wolffenbuttel BHR, 2017, BMC ENDOCR DISORD, V17, DOI 10.1186/s12902-017-0215-1
   World Med Assoc, 2013, JAMA-J AM MED ASSOC, V310, P2191, DOI 10.1001/jama.2013.281053
   Xi B, 2012, OBES REV, V13, P287, DOI 10.1111/j.1467-789X.2011.00944.x
NR 35
TC 32
Z9 35
U1 0
U2 4
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0300-0605
EI 1473-2300
J9 J INT MED RES
JI J. Int. Med. Res.
PD JUL
PY 2019
VL 47
IS 7
BP 3040
EP 3049
DI 10.1177/0300060519851624
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA IN3WH
UT WOS:000478606600026
PM 31144547
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU González-Domenech, CM
   Plaza-Andrades, IJ
   Garrido-Sanchez, L
   Queipo-Ortuño, MI
AF Maria Gonzalez-Domenech, Carmen
   Plaza-Andrades, Isaac J.
   Garrido-Sanchez, Lourdes
   Isabel Queipo-Ortuno, Maria
TI Synergic effect of metabolic syndrome and lipodystrophy on oxidative
   stress and inflammation process in treated HIV-patients
SO ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
LA English
DT Article
DE Metabolic syndrome; Lipodystrophy; HIV; Protease inhibitors;
   Inflammation
ID INFECTED PATIENTS; ANTIRETROVIRAL THERAPY; PROTEASE INHIBITORS;
   DIABETES-MELLITUS; RISK-FACTORS; DISEASE; EVENTS; ADULTS; LIVER
AB The aim of this study was to assess the effect of lipodystrophy (LD) associated to metabolic syndrome (MS) on oxidative stress and inflammation in a cohort of 243 HIV-infected patients with MS, all of them under three different antiretroviral regimens. We collected immunovirological, biochemical and metabolic data, as well as anthropometric measurements. In addition, cardiovascular risk was also assessed by means of Atherogenic Index of Plasma (API) and Framingham Risk Score. The MS-LD patient set was characterized by a lower initial lymphocyte CD4 count and CD4/CD8 ratio and a higher initial viral load than the group without LD. We also found worse lipidic and glycaemic profiles (with lower HDL-cholesterol and higher triglyceride and glucose levels) in the MS-LD group. BMI, systolic blood pressure and Framingham score were significantly increased compared to MS-Non LD. In addition, patients with MS and LD had significantly higher levels of carbonylated proteins, lipid peroxidation, IL-6 and IL-8, as well as a significant decrease in the levels of leptin, adiponectin and antioxidant activities of catalase, super oxide dismutase and glutathione associated enzymes. In MS-LD HIV-1 patients, a significant negative correlation was found between Framingham Risk Score and the antioxidant biomarkers, however a positive association was found between API and protein-C reactive and carbonylated proteins. Segregating by ART, the above-mentioned conditions were worse within the MS-LD group whose treatment contained protease inhibitors, such as lopinavir. In conclusion, HIV-1 infected patients treated for at least six months, especially with regimens including PIs, showed a worsening of inflammatory process and oxidative stress. (C) 2020 Sociedad Espanola de Enfermedades Infecciosas y Microbiologia Clinica. Published by Elsevier Espana, S.L.U. All rights reserved.
C1 [Maria Gonzalez-Domenech, Carmen] Univ Malaga, Sci Coll, Microbiol Dept, Malaga, Spain.
   [Plaza-Andrades, Isaac J.; Garrido-Sanchez, Lourdes] UMA, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Endocrinol & Nutr, Hosp Virgen de la Victoria, Malaga, Spain.
   [Isabel Queipo-Ortuno, Maria] CIMES UMA, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Interctr Oncol Med, Hosp Univ Reg & Virgen de la Victoria, Malaga, Spain.
C3 Universidad de Malaga; Universidad de Malaga; Instituto de Investigacion
   Biomedica de Malaga y Plataforma en Nanomedicina (IBIMA); Universidad de
   Malaga; Instituto de Investigacion Biomedica de Malaga y Plataforma en
   Nanomedicina (IBIMA)
RP González-Domenech, CM (corresponding author), Univ Malaga, Sci Coll, Microbiol Dept, Malaga, Spain.; Garrido-Sanchez, L (corresponding author), UMA, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Endocrinol & Nutr, Hosp Virgen de la Victoria, Malaga, Spain.
EM cmgodo@uma.es; lourgarrido@gmail.com
RI Ortuño, María/AAC-1238-2021; GONZALEZ DOMENECH, CARMEN MARIA/F-6068-2019
OI GONZALEZ DOMENECH, CARMEN MARIA/0000-0001-8248-3904; Garrido-Sanchez,
   Lourdes/0000-0003-0756-9606; QUEIPO ORTUNO, MARIA
   ISABEL/0000-0002-2867-0845
FU Spanish Ministry of Science and Innovation [SAF 2010-17213]; Regional
   Ministry of Health from the Andalusian Government [SAS 111226,
   C-0030-2018, C-0028-2018]; ISCIII [CPI13/00003, CPII18/00030]; European
   Regional Development Fund (ERDF)
FX This work was supported by the Spanish Ministry of Science and
   Innovation [SAF 2010-17213]; the Regional Ministry of Health from the
   Andalusian Government [SAS 111226]; "Miguel Servet Type II" grant
   [CPI13/00003 to M.I.Q.O. and CPII18/00030 to L.G.S.] from ISCIII,
   co-funded by the European Regional Development Fund (ERDF); "Nicolas
   Monardes" research program from the Regional Ministry of Health from the
   Andalusian Government [C-0030-2018 to M.I.Q.O. and C-0028-2018 to
   L.G.S.].
CR Afonso P, 2017, ANTIVIR THER, V22, P645, DOI 10.3851/IMP3160
   [Anonymous], 2006, The IDF Consensus Worldwide Definition of the Metabolic Syndrome
   Aoki M, 2018, MBIO, V9, DOI 10.1128/mBio.02425-17
   Behrens GMN, 2000, DRUG SAFETY, V23, P57, DOI 10.2165/00002018-200023010-00004
   Biswas SK, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/5698931
   Bonfanti P, 2007, JAIDS-J ACQ IMM DEF, V45, P426, DOI 10.1097/QAI.0b013e318074ef83
   Boullart ACI, 2012, BBA-MOL CELL BIOL L, V1821, P867, DOI 10.1016/j.bbalip.2011.10.002
   Brites-Alves C, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01469
   Cachofeiro V, 2008, KIDNEY INT, V74, pS4, DOI 10.1038/ki.2008.516
   De Wit S, 2008, DIABETES CARE, V31, P1224, DOI 10.2337/dc07-2013
   Echecopar-Sabogal J, 2018, INT J STD AIDS, V29, P443, DOI 10.1177/0956462417732226
   Echeverría P, 2017, HIV MED, V18, P782, DOI 10.1111/hiv.12530
   Espiau M, 2017, PEDIATR INFECT DIS J, V36, pE31, DOI 10.1097/INF.0000000000001394
   Estrada V, 2006, METABOLISM, V55, P940, DOI 10.1016/j.metabol.2006.02.024
   Fardet L, 2013, REV MED INTERNE, V34, P614, DOI 10.1016/j.revmed.2012.11.008
   Freitas P, 2011, BMC INFECT DIS, V11, DOI 10.1186/1471-2334-11-246
   Freitas P, 2014, BMC INFECT DIS, V14, DOI 10.1186/1471-2334-14-347
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Gori E, 2016, THER CLIN RISK MANAG, V12, P1659, DOI 10.2147/TCRM.S117980
   Guaraldi G, 2011, CLIN INFECT DIS, V53, P1120, DOI 10.1093/cid/cir627
   He JT, 2020, J ALZHEIMERS DIS, V73, P39, DOI 10.3233/JAD-190764
   Hileman CO, 2012, HIV MED, V13, P609, DOI 10.1111/j.1468-1293.2012.01026.x
   Husain NEOS, 2015, HIV AIDS-RES PALLIAT, V7, P1, DOI 10.2147/HIV.S46028
   Jericó C, 2006, CLIN INVEST ARTERIOS, V18, P51, DOI 10.1016/S0214-9168(06)73656-7
   Krishnan S, 2012, JAIDS-J ACQ IMM DEF, V61, P381, DOI 10.1097/QAI.0b013e3182690e3c
   Lagathu C, 2019, EXPERT OPIN DRUG SAF, V18, P829, DOI 10.1080/14740338.2019.1644317
   Ledergerber B, 2007, CLIN INFECT DIS, V45, P111, DOI 10.1086/518619
   Lemoine M, 2017, AIDS, V31, P1955, DOI 10.1097/QAD.0000000000001587
   Lemoine M, 2012, CURR OPIN INFECT DIS, V25, P10, DOI 10.1097/QCO.0b013e32834ef599
   Lv ZT, 2015, HIV AIDS-RES PALLIAT, V7, P95, DOI 10.2147/HIV.S79956
   Murray CJL, 2014, LANCET, V384, P1005, DOI 10.1016/S0140-6736(14)60844-8
   Nguyen KA, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0150970
   Norris A, 2004, J ASSOC NURSE AIDS C, V15, P46, DOI 10.1177/1055329004271187
   Onat A, 2010, J CLIN LIPIDOL, V4, P89, DOI 10.1016/j.jacl.2010.02.005
   Palacios R, 2007, INT J STD AIDS, V18, P184, DOI 10.1258/095646207780132415
   Rogalska-Plonska M, 2018, KARDIOL POL, V76, P548, DOI 10.5603/KP.a2017.0249
   Tsiodras S, 2010, J INFECTION, V61, P101, DOI 10.1016/j.jinf.2010.06.002
   Vizcarra P, 2019, ANTIVIR THER, V24, P467, DOI 10.3851/IMP3319
   Willig AL, 2016, CURR HIV-AIDS REP, V13, P289, DOI 10.1007/s11904-016-0330-z
   Wilson PW, 2010, UPTODATE TXB OFMEDIC
   World Health Organization, 2017, CHIK VIR FACTSH
NR 41
TC 3
Z9 3
U1 0
U2 6
PU EDICIONES DOYMA S A
PI BARCELONA
PA TRAV DE GRACIA 17-21, 08021 BARCELONA, SPAIN
SN 0213-005X
EI 1578-1852
J9 ENFERM INFEC MICR CL
JI Enferm. Infec. Microbiol. Clin.
PD JUN-JUL
PY 2022
VL 40
IS 6
BP 310
EP 316
DI 10.1016/j.eimc.2020.11.019
EA JUN 2022
PG 7
WC Infectious Diseases; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Microbiology
GA 3J6BL
UT WOS:000833478500005
PM 35680349
OA Green Accepted
DA 2025-06-11
ER

PT J
AU El Midaoui, A
   Fantus, IG
   Boughrous, AA
   Couture, R
AF El Midaoui, Adil
   Fantus, I. George
   Boughrous, Ali Ait
   Couture, Rejean
TI Beneficial Effects of Alpha-Lipoic Acid on Hypertension, Visceral
   Obesity, UCP-1 Expression and Oxidative Stress in Zucker Diabetic Fatty
   Rats
SO ANTIOXIDANTS
LA English
DT Article
DE type 2 diabetes; metabolic syndrome; insulin resistance; visceral
   obesity; hypertension; oxidative stress; alpha-lipoic acid
ID ENHANCED SUPEROXIDE-PRODUCTION; INSULIN-RESISTANCE; ADIPOSE-TISSUE;
   NADH/NADPH OXIDASE; GLUCOSE-METABOLISM; DYSFUNCTION; MECHANISM;
   INFLAMMATION; ADIPOCYTES; GLYCATION
AB Evidence suggests that oxidative stress plays a major role in the development of metabolic syndrome. This study aims to investigate whether alpha-lipoic acid (LA), a potent antioxidant, could exert beneficial outcomes in Zucker diabetic fatty (ZDF) rats. Male 6-week-old ZDF rats and their lean counterparts (ZL) were fed for six weeks with a standard diet or a chow diet supplemented with LA (1 g/kg feed). At 12 weeks of age, ZDF rats exhibited an increase in systolic blood pressure, epididymal fat weight per body weight, hyperglycemia, hyperinsulinemia, insulin resistance (HOMA index), adipocyte hypertrophy and a rise in basal superoxide anion (O-2 center dot(-)) production in gastrocnemius muscle and a downregulation of epididymal uncoupled protein-1 (UCP-1) protein staining. Treatment with LA prevented the development of hypertension, the rise in whole body weight and O-2 center dot(-) production in gastrocnemius muscle, but failed to affect insulin resistance, hyperglycemia and hyperinsulinemia in ZDF rats. LA treatment resulted in a noticeable increase of pancreatic weight and a further adipocyte hypertrophy, along with a decrease in epididymal fat weight per body weight ratio associated with an upregulation of epididymal UCP-1 protein staining in ZDF rats. These findings suggest that LA was efficacious in preventing the development of hypertension, which could be related to its antioxidant properties. The anti-visceral obesity effect of LA appears to be mediated by its antioxidant properties and the induction of UCP-1 protein at the adipose tissue level in ZDF rats. Disorders of glucose metabolism appear, however, to be mediated by other unrelated mechanisms in this model of metabolic syndrome.
C1 [El Midaoui, Adil; Couture, Rejean] Univ Montreal, Fac Med, Dept Pharmacol & Physiol, Montreal, PQ H3C 3J7, Canada.
   [El Midaoui, Adil; Boughrous, Ali Ait] Moulay Ismail Univ Meknes, Fac Sci & Tech Errachidia, Dept Biol, Res Team Biol Environm & Hlth, Errachidia 52000, Morocco.
   [Fantus, I. George] McGill Univ, Hlth Ctr Res Inst, Dept Med, Div Endocrinol & Metab, Montreal, PQ H4A 3J1, Canada.
C3 Universite de Montreal; Moulay Ismail University of Meknes; McGill
   University
RP El Midaoui, A (corresponding author), Univ Montreal, Fac Med, Dept Pharmacol & Physiol, Montreal, PQ H3C 3J7, Canada.; El Midaoui, A (corresponding author), Moulay Ismail Univ Meknes, Fac Sci & Tech Errachidia, Dept Biol, Res Team Biol Environm & Hlth, Errachidia 52000, Morocco.
EM adil.el.midaoui@umontreal.ca; george.fantus@mcgill.ca;
   boughrous@gmail.com; rejean.couture@umontreal.ca
RI Fantus, Ivan/E-8973-2010
FU Canadian Institutes of Health Research (CIHR) [MOP-119329]; Membrane
   Protein Biophysics Group (GEPROM) of the Universite de Montreal
FX This work was supported by Grants (to R.C.) from the Canadian Institutes
   of Health Research (CIHR, MOP-119329) and the Membrane Protein
   Biophysics Group (GEPROM) of the Universite de Montreal. The funders had
   no role in the design, analysis or writing of this article.
CR BAYNES JW, 1991, DIABETES, V40, P405, DOI 10.2337/diabetes.40.4.405
   Beswick RA, 2001, HYPERTENSION, V38, P1107, DOI 10.1161/hy1101.093423
   Biewenga GP, 1997, GEN PHARMACOL, V29, P315, DOI 10.1016/S0306-3623(96)00474-0
   Blühre M, 2009, EXP CLIN ENDOCR DIAB, V117, P241, DOI 10.1055/s-0029-1192044
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   El Akoum S, 2017, OBES SCI PRACT, V3, P352, DOI 10.1002/osp4.117
   El Midaoui A, 2006, AM J HYPERTENS, V19, P407, DOI 10.1016/j.amjhyper.2005.11.006
   El Midaoui A, 2005, J HYPERTENS, V23, P581
   EL Midaoui A, 2003, AM J HYPERTENS, V16, P173, DOI 10.1016/S0895-7061(02)03253-3
   El Midaoui A, 2002, HYPERTENSION, V39, P303, DOI 10.1161/hy0202.104345
   El Midaoui A, 2008, CAN J PHYSIOL PHARM, V86, P752, DOI 10.1139/Y08-090
   El Midaoui A, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18112492
   El Midaoui A, 2015, J DIABETES METAB, V6, DOI 10.4172/2155-6156.1000556
   El Midaoui A, 2011, CAN J PHYSIOL PHARM, V89, P743, DOI [10.1139/Y11-072, 10.1139/y11-072]
   Estrada DE, 1996, DIABETES, V45, P1798, DOI 10.2337/diabetes.45.12.1798
   Vázquez GF, 2018, J PINEAL RES, V64, DOI 10.1111/jpi.12472
   Fukui T, 1997, CIRC RES, V80, P45, DOI 10.1161/01.RES.80.1.45
   Gopaul NK, 2001, DIABETOLOGIA, V44, P706, DOI 10.1007/s001250051679
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   HUNT JV, 1991, FREE RADICAL RES COM, V12-3, P115, DOI 10.3109/10715769109145775
   JACOB S, 1995, ARZNEIMITTEL-FORSCH, V45-2, P872
   Jacob S, 1999, FREE RADICAL BIO MED, V27, P309, DOI 10.1016/S0891-5849(99)00089-1
   Jacob S, 1996, DIABETES, V45, P1024, DOI 10.2337/diabetes.45.8.1024
   Jun T, 1996, J HUM HYPERTENS, V10, P305
   Koçak G, 2000, DIABETES NUTR METAB, V13, P308
   Lapa C, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-17148-w
   Lodge John K., 1997, Journal of Applied Nutrition, V49, P3
   Marchetti P, 2004, J CLIN ENDOCR METAB, V89, P5535, DOI 10.1210/jc.2004-0150
   Muellenbach EA, 2008, METABOLISM, V57, P1465, DOI 10.1016/j.metabol.2008.05.018
   OHARA Y, 1993, J CLIN INVEST, V91, P2546, DOI 10.1172/JCI116491
   Ohno H, 2012, CELL METAB, V15, P395, DOI 10.1016/j.cmet.2012.01.019
   Oltman CL, 2008, DIABETES OBES METAB, V10, P64, DOI 10.1111/j.1463-1326.2007.00814.x
   Pashaj A, 2013, PHYSIOL GENOMICS, V45, P1136, DOI 10.1152/physiolgenomics.00138.2013
   Peschechera A, 2013, ARCH PHYSIOL BIOCHEM, V119, P151, DOI 10.3109/13813455.2013.796995
   Petrovic N, 2010, J BIOL CHEM, V285, P7153, DOI 10.1074/jbc.M109.053942
   Podda M, 2001, CLIN EXP DERMATOL, V26, P578, DOI 10.1046/j.1365-2230.2001.00902.x
   Rochette L, 2013, MOL NUTR FOOD RES, V57, P114, DOI 10.1002/mnfr.201200608
   Saengsirisuwan V, 2004, AM J PHYSIOL-ENDOC M, V287, pE529, DOI 10.1152/ajpendo.00013.2004
   Sato N, 2010, DIABETES, V59, P1092, DOI 10.2337/db09-1432
   Seo EY, 2012, NUTR RES PRACT, V6, P195, DOI 10.4162/nrp.2012.6.3.195
   Song KH, 2005, BIOCHEM BIOPH RES CO, V326, P197, DOI 10.1016/j.bbrc.2004.10.213
   Stanford Kristin I, 2013, Hepatobiliary Surg Nutr, V2, P286, DOI 10.3978/j.issn.2304-3881.2013.09.02
   Stanford KI, 2013, J CLIN INVEST, V123, P215, DOI 10.1172/JCI62308
   Streeper RS, 1997, AM J PHYSIOL-ENDOC M, V273, pE185, DOI 10.1152/ajpendo.1997.273.1.E185
   Tian YF, 2012, EUR J CLIN INVEST, V42, P637, DOI 10.1111/j.1365-2362.2011.02630.x
   Urakawa H, 2003, J CLIN ENDOCR METAB, V88, P4673, DOI 10.1210/jc.2003-030202
   van Bree BWJ, 2016, SCI REP-UK, V6, DOI 10.1038/srep22854
   Vernochet C, 2009, MOL CELL BIOL, V29, P4714, DOI 10.1128/MCB.01899-08
   Vessiêres E, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0068217
   Zalba G, 2000, HYPERTENSION, V35, P1055, DOI 10.1161/01.HYP.35.5.1055
NR 51
TC 14
Z9 14
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD DEC
PY 2019
VL 8
IS 12
AR 648
DI 10.3390/antiox8120648
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA KB6WN
UT WOS:000506633000081
PM 31888243
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bhutia, RD
   Sherpa, ML
   Singh, TA
   Khandelwal, B
AF Bhutia, Rinchen Doma
   Sherpa, Mingma Lhamu
   Singh, T. A.
   Khandelwal, Bidita
TI Oxidative stress in metabolic syndrome & its association with DNA-strand
   break
SO INDIAN JOURNAL OF MEDICAL RESEARCH
LA English
DT Article
DE DNA-strand break; hydrogen peroxide; metabolic syndrome; oxidative
   stress; ROS
ID HYDROGEN-PEROXIDE; DAMAGE; CANCER; PROTEIN; MODEL; ASSAY; RISK
AB Background & objectives: Oxidative stress (OS) is associated with numerous components of metabolic syndrome (MetS). This study was aimed to investigate if hydrogen peroxide (H2O2) as the reactive oxygen species was capable of depicting OS in MetS, and If MetS patients showed DNA damage in the form of DNA strand breaks (DSB).
   Methods: A total of 160 participants (90 males, 70 females) >= 20 yr of age were categorized into four groups based on the number of MetS risk parameters (n=40 in each group). Sugar and lipid profile, H2O2 concentration in blood and DNA-strand breaks were measured.
   Results: DSB was significantly more in those with MetS (n=40) than those without (n=120) whereas H2O2 levels were the same in both the study groups. The number of DSB differed significantly between the control and 3 risk factor groups. DSB was also higher in groups with 2 and 1 risk factors compared to 0 risk but the difference was not significant H2O2 level was higher in groups with 3, 2 and 1 risk factors compared to 0 risk group but the difference was not significant. The H2O2 level correlated positively with triglyceride values but not with other MetS risk parameters. There was no significant correlation between DSB and MetS risk parameters.
   Interpretation & conclusions: Our findings showed a cumulative and synergistic effect of the risk factors of MetS on DSB. Individuals with three risk parameters had a greater effect on DNA damage than in those with two or one risk parameter. Although plasma H2O2 level increased with an increase in the fat depots, use of H2O2 to depict OS in MetS should he coupled with an adjunct and estimation of DSB in peripheral blood lymphocytes may be used as indicator of OS in MetS patients.
C1 [Bhutia, Rinchen Doma; Sherpa, Mingma Lhamu; Singh, T. A.] Sikkim Manipal Inst Med Sci, Dept Biochem, Gangtok, India.
   [Khandelwal, Bidita] Sikkim Manipal Inst Med Sci, Dept Med, Gangtok, India.
C3 Sikkim Manipal University; Sikkim Manipal University
RP Bhutia, RD (corresponding author), Sikkim Manipal Inst Med Sci, Dept Biochem, 5th Mile, Tadong 737102, Gangtok, India.
EM nehcnir@yahoo.co.in
RI khandelwal, bidita/K-4935-2012; Bhutia, Rinchen/AAE-6172-2021; Sherpa,
   Mingma/ABB-7061-2021
OI Bhutia, Rinchen Doma/0000-0001-8463-2854; Sherpa, Mingma
   L/0000-0002-5905-6127
FU Indian Council of Medical Research, New Delhi, undertaken in the
   department of Biochemistry [IEC/192/12-05(a), 5/7/1099/2013-RCH]; IL
   Biotech Hub Project North Eastern Region-Biotechnology Programme
   Management Cell, Department of Biotechnology, India
FX This study was a part of our research project [IEC/192/12-05(a)] on
   'Metabolic Syndrome' (5/7/1099/2013-RCH) that was supported by the
   Indian Council of Medical Research, New Delhi, undertaken in the
   department of Biochemistry. Instruments utilized for the project were
   funded by the IL Biotech Hub Project North Eastern Region-Biotechnology
   Programme Management Cell, Department of Biotechnology, India.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Armutcu F, 2008, CLIN CHEM LAB MED, V46, P785, DOI 10.1515/CCLM.2008.166
   Bloomer RJ, 2009, OXID MED CELL LONGEV, V2, P19, DOI 10.4161/oxim.2.1.7860
   BOVERIS A, 1973, BIOCHEM J, V134, P707, DOI 10.1042/bj1340707
   Brown MR, 1999, CIRC RES, V85, P524, DOI 10.1161/01.RES.85.6.524
   Chen LW, 2001, JNCI-J NATL CANCER I, V93, P1872, DOI 10.1093/jnci/93.24.1872
   De Bont R, 2004, MUTAGENESIS, V19, P169, DOI 10.1093/mutage/geh025
   Esposito K, 2012, DIABETES CARE, V35, P2402, DOI 10.2337/dc12-0336
   FREI B, 1988, ANAL BIOCHEM, V175, P120, DOI 10.1016/0003-2697(88)90369-7
   Gelaleti RB, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/1758-5996-7-1
   Griffin S, 1996, CURR BIOL, V6, P497, DOI 10.1016/S0960-9822(02)00525-0
   Guengerich F., 2014, EXOCYCLIC ADDUCTS MO
   Gyori BM, 2014, REDOX BIOL, V2, P457, DOI 10.1016/j.redox.2013.12.020
   Halliwell B, 2000, FEBS LETT, V486, P10, DOI 10.1016/S0014-5793(00)02197-9
   Henzler T, 2000, J EXP BOT, V51, P2053, DOI 10.1093/jexbot/51.353.2053
   Kalyanaraman B, 2013, REDOX BIOL, V1, P244, DOI 10.1016/j.redox.2013.01.014
   Karaman A, 2015, MUTAT RES-GEN TOX EN, V782, P30, DOI 10.1016/j.mrgentox.2015.03.009
   Lacy F, 1998, FREE RADICAL BIO MED, V25, P720, DOI 10.1016/S0891-5849(98)00154-3
   Lee I, 2011, B KOREAN CHEM SOC, V32, P2187, DOI 10.5012/bkcs.2011.32.7.2187
   Madamanchi NR, 2010, CIRC RES, V107, P940, DOI 10.1161/CIRCRESAHA.110.230904
   Malinouski M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0014564
   National Institute on Aging, BIOL AG
   PoolZobel BL, 1997, MUTAT RES-FUND MOL M, V375, P105, DOI 10.1016/S0027-5107(97)00006-7
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Smith TR, 2003, CARCINOGENESIS, V24, P883, DOI 10.1093/carcin/bgg037
   Spitz MR, 2003, CANCER EPIDEM BIOMAR, V12, P689
   STADTMAN ER, 1992, SCIENCE, V257, P1220, DOI 10.1126/science.1355616
   Tornovsky-Babeay S, 2014, CELL METAB, V19, P109, DOI 10.1016/j.cmet.2013.11.007
   Valko M, 2004, MOL CELL BIOCHEM, V266, P37, DOI 10.1023/B:MCBI.0000049134.69131.89
   Van de Bittner GC, 2010, P NATL ACAD SCI USA, V107, P21316, DOI 10.1073/pnas.1012864107
   Wang HS, 2005, J BIOPHARM STAT, V15, P799, DOI 10.1081/BIP-200067789
NR 31
TC 3
Z9 4
U1 0
U2 6
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0971-5916
J9 INDIAN J MED RES
JI Indian J. Med. Res.
PD OCT
PY 2018
VL 148
IS 4
BP 435
EP 440
DI 10.4103/ijmr.IJMR_620_17
PG 6
WC Immunology; Medicine, General & Internal; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; General & Internal Medicine; Research & Experimental
   Medicine
GA HI4QS
UT WOS:000456435900011
PM 30666006
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Adler, G
   Skonieczna-Zydecka, K
   Madlani, A
   Ogonowski, J
   Grochans, E
   Pierzak-Sominka, J
   Brodowski, J
   Karakiewicz, B
AF Adler, Grazyna
   Skonieczna-Zydecka, Karolina
   Madlani, Agnieszka
   Ogonowski, Jaroslaw
   Grochans, Elzbieta
   Pierzak-Sominka, Joanna
   Brodowski, Jacek
   Karakiewicz, Beata
TI Association between depression, parameters of adiposity and genetic
   polymorphisms of pro-inflammatory cytokines: IL-1α, IL-1β,
   IL-2 and IL-6 in subjects over 55 years old
SO ACTA BIOCHIMICA POLONICA
LA English
DT Article
DE cross sectional study; genetic variants of cytokines; obesity;
   depression
ID BODY-MASS INDEX; C-REACTIVE PROTEIN; MAJOR DEPRESSION; METABOLIC
   SYNDROME; SERUM-LEVELS; OBESITY; FAT; ADULTS; INTERLEUKIN-1-BETA;
   METAANALYSIS
AB During the last few decades, adiposity has become a relatively common phenomenon worldwide. The available data on the effects of pro-inflammatory factors in both depression and adiposity has been attracting great attention. Aim. We sought to assess the prevalence of -889C> T IL-1 alpha, -31T> C and -511C> T IL-1 beta, -330T> G IL-2 and -174G> C IL-6 genes and their association with adiposity and depression in Polish subjects. Methods. A cohort study was conducted in 2013/2014, covering a sample of 297 individuals (217 female and 80 male). Anthropometric data was handled using the BIA analysis method, while for genotyping PCR-RFLP techniques were used. Results. A positive correlation between depression and anthropometric parameters: adipose tissue (in kg) and adipose tissue (in %) (R= 0.135 and p= 0.02, R= 0.114 and p< 0.05, respectively) was found. No association between studied polymorphisms and depression was observed. Conclusion. Although it was not possible to demonstrate any influence of the studied polymorphisms as the genetic modulator of depression, authors believe that the presented data are noticeable and may provide the basis for future studies on larger groups.
C1 [Adler, Grazyna; Skonieczna-Zydecka, Karolina; Madlani, Agnieszka] Pomeranian Med Univ, Dept Gerontobiol, Szczecin, Poland.
   [Ogonowski, Jaroslaw] Pomeranian Med Univ, Dept Civilizat Dis, Szczecin, Poland.
   [Grochans, Elzbieta] Pomeranian Med Univ, Dept Nursing, Szczecin, Poland.
   [Pierzak-Sominka, Joanna] Pomeranian Med Univ, Dept Publ Hlth, Szczecin, Poland.
   [Brodowski, Jacek] Pomeranian Med Univ, Lab Primary Hlth Care, Szczecin, Poland.
   [Karakiewicz, Beata] Pomeranian Med Univ, Chair & Dept Publ Hlth, Szczecin, Poland.
C3 Pomeranian Medical University; Pomeranian Medical University; Pomeranian
   Medical University; Pomeranian Medical University; Pomeranian Medical
   University; Pomeranian Medical University
RP Adler, G (corresponding author), Pomeranian Med Univ, Dept Gerontobiol, Szczecin, Poland.
EM gra2@op.pl
RI Pierzak-Sominka, Joanna/A-7956-2015; Adler, Grażyna/O-7928-2014;
   Grochans, Elżbieta/K-8659-2014; Skonieczna-Zydecka,
   Karolina/K-7252-2014; Karakiewicz, Beata/N-2083-2014; Grochans,
   Elzbieta/M-1593-2014; Brodowski, Jacek/A-5916-2015
OI Skonieczna-Zydecka, Karolina/0000-0002-3430-9079; Karakiewicz,
   Beata/0000-0001-6527-7287; Grochans, Elzbieta/0000-0002-3679-7002;
   Brodowski, Jacek/0000-0002-6853-9155
CR Akbaraly TN, 2009, DIABETES CARE, V32, P499, DOI 10.2337/dc08-1358
   Albinski R, 2011, PSYCHIATR POL, V45, P555
   Arrieta MC, 2006, GUT, V55, DOI 10.1136/gut.2005.085373
   Barreira TV, 2011, JAMA-J AM MED ASSOC, V306, P828, DOI 10.1001/jama.2011.1189
   Basterzi AD, 2005, HUM PSYCHOPHARM CLIN, V20, P473, DOI 10.1002/hup.717
   Baumeister H, 2007, INT J OBESITY, V31, P1155, DOI 10.1038/sj.ijo.0803556
   BEISEL WR, 1981, CANCER RES, V41, P3797
   Besedovsky HO, 1996, ENDOCR REV, V17, P64, DOI 10.1210/edrv-17-1-64
   Borkowska P, 2011, J MOL NEUROSCI, V44, P12, DOI 10.1007/s12031-011-9507-5
   Bosker FJ, 2011, MOL PSYCHIATR, V16, P516, DOI 10.1038/mp.2010.38
   Bouchard C, 2007, INT J OBESITY, V31, P1552, DOI 10.1038/sj.ijo.0803653
   Bufalino C, 2013, BRAIN BEHAV IMMUN, V31, P31, DOI 10.1016/j.bbi.2012.04.009
   Buret AG, 2006, AM J PATHOL, V168, P3, DOI 10.2353/ajpath.2006.050958
   Camhi SM, 2011, OBESITY, V19, P402, DOI 10.1038/oby.2010.248
   Cartier A, 2009, ANN MED, V41, P471, DOI 10.1080/07853890903022801
   Chung S, 2006, ENDOCRINOLOGY, V147, P5340, DOI 10.1210/en.2006-0536
   Clement K, 2010, EUROPEAN ENDOCRINOLO, V5, P10, DOI DOI 10.1210/JC.2009-1912
   Cohen BE, 2010, PSYCHIAT RES, V175, P133, DOI 10.1016/j.psychres.2009.02.004
   Corwin EJ, 2008, BIOL RES NURS, V10, P128, DOI 10.1177/1099800408323220
   De Berardis D, 2010, INT J IMMUNOPATH PH, V23, P417, DOI 10.1177/039463201002300204
   de Wit L, 2010, PSYCHIAT RES, V178, P230, DOI 10.1016/j.psychres.2009.04.015
   Diniz BS, 2010, AM J GERIAT PSYCHIAT, V18, P172, DOI 10.1097/JGP.0b013e3181c2947f
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Dunn AJ, 2005, NEUROSCI BIOBEHAV R, V29, P891, DOI 10.1016/j.neubiorev.2005.03.023
   Felger JC, 2013, NEUROSCIENCE, V246, P199, DOI 10.1016/j.neuroscience.2013.04.060
   Gao QJ, 2009, WORLD J GASTROENTERO, V15, P5610, DOI 10.3748/wjg.15.5610
   Harkins JM, 2004, J NUTR, V134, P2673, DOI 10.1093/jn/134.10.2673
   Haroon E, 2012, NEUROPSYCHOPHARMACOL, V37, P137, DOI 10.1038/npp.2011.205
   Heo M, 2006, INT J OBESITY, V30, P513, DOI 10.1038/sj.ijo.0803122
   Herva A, 2006, INT J OBESITY, V30, P520, DOI 10.1038/sj.ijo.0803174
   Howe LR, 2013, CLIN CANCER RES, V19, P6074, DOI 10.1158/1078-0432.CCR-12-2603
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Hwang JP, 2009, NEUROMOL MED, V11, P322, DOI 10.1007/s12017-009-8078-x
   Jackson AS, 2002, INT J OBESITY, V26, P789, DOI 10.1038/sj.ijo.0802006
   Khairova RA, 2009, INT J NEUROPSYCHOPH, V12, P561, DOI 10.1017/S1461145709009924
   Khaodhiar L, 2004, JPEN-PARENTER ENTER, V28, P410, DOI 10.1177/0148607104028006410
   Lee YK, 2010, SCIENCE, V330, P1768, DOI 10.1126/science.1195568
   Lim WJ, 2005, ARCH INTERN MED, V165, P910, DOI 10.1001/archinte.165.8.910
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Maes M, 2012, EXPERT OPIN THER TAR, V16, P1097, DOI 10.1517/14728222.2012.718331
   Maes M, 2012, PROG NEURO-PSYCHOPH, V36, P169, DOI 10.1016/j.pnpbp.2011.09.006
   Martinac M, 2014, ACTA CLIN CROAT, V53, P55
   Miller AH, 2009, BIOL PSYCHIAT, V65, P732, DOI 10.1016/j.biopsych.2008.11.029
   Miller GE, 2003, BRAIN BEHAV IMMUN, V17, P276, DOI 10.1016/S0889-1591(03)00057-6
   Misener VL, 2008, NEUROPSYCHOBIOLOGY, V58, P71, DOI 10.1159/000159775
   O'Brien SM, 2004, HUM PSYCHOPHARM CLIN, V19, P397, DOI 10.1002/hup.609
   Ogbera AO, 2010, DIABETOL METAB SYNDR, V2, DOI 10.1186/1758-5996-2-1
   Park HS, 2005, DIABETES RES CLIN PR, V69, P29, DOI 10.1016/j.diabres.2004.11.007
   Aparicio JP, 2011, EUR SPINE J, V20, P383, DOI 10.1007/s00586-011-1915-2
   Pizzagalli DA, 2009, AM J PSYCHIAT, V166, P702, DOI 10.1176/appi.ajp.2008.08081201
   Raison CL, 2013, MOL PSYCHIATR, V18, P15, DOI 10.1038/mp.2012.2
   Raison CL, 2009, BIOL PSYCHIAT, V65, P296, DOI 10.1016/j.biopsych.2008.08.010
   Schiepers OJG, 2005, PROG NEURO-PSYCHOPH, V29, P201, DOI 10.1016/j.pnpbp.2004.11.003
   Schmidt FM, 2014, J PSYCHIATR RES, V55, P29, DOI 10.1016/j.jpsychires.2014.04.021
   September AV, 2011, BRIT J SPORT MED, V45, P1040, DOI 10.1136/bjsm.2010.076760
   Silverman MN, 2005, VIRAL IMMUNOL, V18, P41, DOI 10.1089/vim.2005.18.41
   Simon GE, 2008, GEN HOSP PSYCHIAT, V30, P32, DOI 10.1016/j.genhosppsych.2007.09.001
   Sluzewska A, 1996, PSYCHIAT RES, V64, P161, DOI 10.1016/S0165-1781(96)02783-7
   Suganami T, 2010, J LEUKOCYTE BIOL, V88, P33, DOI 10.1189/jlb.0210072
   Takeuchi T, 2009, DIABETES-METAB RES, V25, P762, DOI 10.1002/dmrr.1041
   Todhunter CE, 2005, GUT, V54, P1579, DOI 10.1136/gut.2005.064212
   Ufnal M, 2011, POSTEP HIG MED DOSW, V65, P228, DOI 10.5604/17322693.939284
   Ujcic-Voortman JK, 2012, OBES REV, V13, P2, DOI 10.1111/j.1467-789X.2011.00932.x
   Um JY, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0029524
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Wellen KE, 2003, J CLIN INVEST, V112, P1785, DOI 10.1172/JCI20514
   World Health Organization (WHO), Obesity and overweight
   YESAVAGE JA, 1983, J PSYCHIATR RES, V17, P37, DOI 10.1016/0022-3956(82)90033-4
   Younger WYY, 2003, NEUROPSYCHOPHARMACOL, V28, P1182, DOI 10.1038/sj.npp.1300172
NR 69
TC 9
Z9 9
U1 0
U2 7
PU ACTA BIOCHIMICA POLONICA
PI WARSAW
PA PASTEURA 3, 02-093 WARSAW, POLAND
SN 0001-527X
EI 1734-154X
J9 ACTA BIOCHIM POL
JI Acta Biochim. Pol.
PY 2016
VL 63
IS 2
BP 253
EP 259
DI 10.18388/abp.2015_1063
PG 7
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DX9OE
UT WOS:000384724200011
PM 26934083
OA gold
DA 2025-06-11
ER

PT J
AU Gomes, HM
   Silveira, AK
   Gasparotto, J
   Bortolin, RC
   Terra, SR
   Brum, PO
   Gelain, DP
   Moreira, JCF
AF Gomes, Henrique Mautone
   Silveira, Alexandre K.
   Gasparotto, Juciano
   Bortolin, Rafael Calixto
   Terra, Silvia R.
   Brum, Pedro O.
   Gelain, Daniel P.
   Fonseca Moreira, Jose C.
TI Effects of coconut oil long-term supplementation in Wistar rats during
   metabolic syndrome- regulation of metabolic conditions involving glucose
   homeostasis, inflammatory signals, and oxidative stress
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Coconut Oil; Metabolic Syndrome; Hepatic Oxidative Stress; Conjugated
   Dienes
ID INSULIN-RESISTANCE; FATTY-ACIDS; FRUCTOSE; OBESITY; LIVER; ADIPOSITY;
   ALBUMIN; MODEL
AB This study was designed to evaluate the long-term effects of Fructose (20%) feeding in rats, simulating metabolic syndrome (MetS), and the effects of coconut oil (C.O.) supplementation when administered in a MetS context. MetS is a cluster of systemic conditions that represent an increased chance of developing cardiovascular diseases and type 2 diabetes in the future. C.O. has been the target of media speculation, and recent studies report inconsistent results. C.O. improved glucose homeostasis and reduced fat accumulation in Fructose-fed rats while decreasing the levels of triglycerides (TGs) in the liver. C.O. supplementation also increased TGs levels and fructosamine in serum during MetS, possibly due to white adipose tissue breakdown and high fructose feeding. Pro-inflammatory cytokines IL-1 beta and TNF-alpha were also increased in rats treated with Fructose and C.O. Oxidative stress marker nitrotyrosine is increased in fructose-fed animals, and C.O. treatment did not prevent this damage. No significant changes were observed in lipoperoxidation marker 4-Hydroxynonenal; however, fructose feeding increased total conjugated dienes and caused conjugated dienes to switch their conformation from cis-trans to trans-trans, which was not prevented by C.O. treatment. Potential benefits of C.O. have been reported with inconsistent results, and indeed we observed some benefits of C.O. supplementation in aiding weight loss, fat accumulation, and improving glucose homeostasis. Nonetheless, we also demonstrated that long-term C.O. supplementation could present some problematic effects with higher risk for individuals suffering MetS, including increased TGs and fructosamine levels and conformational changes in dienes. (c) 2023 Elsevier Inc. All rights reserved.
C1 [Gomes, Henrique Mautone; Silveira, Alexandre K.; Gelain, Daniel P.; Fonseca Moreira, Jose C.] Fed Univ Rio Grande do Sul UFRGS, Inst Basic Hlth Sci, Ctr Oxidat Stress Studies, Dept Biochem, Porto Alegre, RS, Brazil.
   [Gasparotto, Juciano] Fed Univ Alfenas UNIFAL, Inst Biomed Sci, Dept Biochem, Alfenas, MG, Brazil.
   [Bortolin, Rafael Calixto] Univ Costa, Dept Ingn Civil & Ambiental, Barranquilla, Atlantico, Colombia.
   [Terra, Silvia R.] Univ Santa Catarina, Hosp Vet UNISUL, Ave Jose Acacio Moreira 787, Tubarao, SC, Brazil.
   [Brum, Pedro O.] Univ Wien, Dept Microbiol Immunol & Genet, Dr Bohr Gasse 9, A-1030 Vienna, Austria.
   [Gomes, Henrique Mautone] Dept Bioquim, Rua Ramiro Barcelos 2600 Anexo, BR-90035003 Porto Alegre, RS, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Universidade Federal de
   Alfenas; Universidad de la Costa; University of Vienna
RP Gomes, HM (corresponding author), Dept Bioquim, Rua Ramiro Barcelos 2600 Anexo, BR-90035003 Porto Alegre, RS, Brazil.
EM hm.gomes93@gmail.com
RI moreira, jose/AAO-6400-2021; Gomes, Henrique/AAP-2363-2021; Bortolin,
   Rafael/O-2711-2014; Gelain, Daniel/I-5144-2013; Brum,
   Patricia/E-6605-2011; Gasparotto, Juciano/K-3239-2013
OI Ozorio Brum, Pedro/0000-0002-5858-8017; Mautone Gomes,
   Henrique/0000-0001-5976-197X; Gasparotto, Juciano/0000-0003-2545-7288
FU Brazilian research agency Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq) [400437/2013-9, 443514/2014-3,
   401260/2014-3]; Brazilian research agency Fundacao de Amparo a Pesquisa
   do Estado do Rio Grande do Sul (FAPERGS) [2299-2551/14-6]; Brazilian
   research agency Propesq-UFRGS; Brazilian research agency Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
FX This work was supported by funds from the Brazilian research agencies
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
   #400437/2013-9, #443514/2014-3 and #401260/2014-3, Fundacao de Amparo a
   Pesquisa do Estado do Rio Grande do Sul (FAPERGS) #2299-2551/14-6,
   Propesq-UFRGS and Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior (CAPES) .
CR Adeyemi WJ, 2020, BIOMED PHARMACOTHER, V126, DOI 10.1016/j.biopha.2020.110110
   Albracht-Schulte K, 2018, J NUTR BIOCHEM, V58, P1, DOI 10.1016/j.jnutbio.2018.02.012
   [Anonymous], 2003, WHY HAVE AM BECOME M
   Bagul PK, 2012, PHARMACOL RES, V66, P260, DOI 10.1016/j.phrs.2012.05.003
   Bandookwala M, 2020, INT J NEUROSCI, V130, P1047, DOI 10.1080/00207454.2020.1713776
   Basciano Heather, 2005, Nutr Metab (Lond), V2, P5, DOI 10.1186/1743-7075-2-5
   Bhagya D, 2012, ASIAN PAC J TROP MED, V5, P270, DOI 10.1016/S1995-7645(12)60038-8
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Calderón-Torres CM, 2023, CURR MOL MED, V23, P358, DOI 10.2174/1566524022666220324114027
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Clegg ME, 2010, INT J FOOD SCI NUTR, V61, P653, DOI 10.3109/09637481003702114
   Crescenzo R, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00411
   Dandona P, 2004, TRENDS IMMUNOL, V25, P4, DOI 10.1016/j.it.2003.10.013
   Donaldson J, 2019, J SCI FOOD AGR, V99, P6954, DOI 10.1002/jsfa.9984
   Duarte AC, 2022, LIPIDS HEALTH DIS, V21, DOI 10.1186/s12944-022-01685-z
   Dupas J, 2017, BIOMED RES INT, V2017, DOI 10.1155/2017/2494067
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   ELLMAN GL, 1959, ARCH BIOCHEM BIOPHYS, V82, P70, DOI 10.1016/0003-9861(59)90090-6
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Garcia-Garcia A, 2012, CURR MOL MED, V12, P681, DOI 10.2174/156652412800792543
   Grattagliano I, 2008, J NUTR BIOCHEM, V19, P491, DOI 10.1016/j.jnutbio.2007.06.011
   Halliwell B., 2015, Free Radicals in Biology and Medicine
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Jahn D, 2019, BBA-MOL BASIS DIS, V1865, P943, DOI 10.1016/j.bbadis.2018.06.023
   Jürgens H, 2005, OBES RES, V13, P1146, DOI 10.1038/oby.2005.136
   Kagota S, 2013, MICROVASC RES, V88, P70, DOI 10.1016/j.mvr.2013.04.001
   Kannappan S, 2010, EUR J PHARMACOL, V645, P177, DOI 10.1016/j.ejphar.2010.07.015
   Kikuchi Y, 2005, NEPHROL DIAL TRANSPL, V20, P1573, DOI 10.1093/ndt/gfh888
   Kunitomo M, 2008, J PHARMACOL SCI, V107, P128, DOI 10.1254/jphs.FP0072365
   Lee WC, 2011, J UROLOGY, V186, P318, DOI 10.1016/j.juro.2011.03.037
   López-Salazar V, 2021, J NUTR BIOCHEM, V94, DOI 10.1016/j.jnutbio.2021.108751
   Lottenberg AM, 2012, J NUTR BIOCHEM, V23, P1027, DOI 10.1016/j.jnutbio.2012.03.004
   Martins CC, 2021, CLIN BIOCHEM, V89, P63, DOI 10.1016/j.clinbiochem.2020.12.007
   Mittman N, 2010, KIDNEY INT, V78, pS41, DOI 10.1038/ki.2010.193
   Mohamed AI, 2002, J NUTR BIOCHEM, V13, P435, DOI 10.1016/S0955-2863(02)00196-1
   Ogbolu DO, 2007, J MED FOOD, V10, P384, DOI 10.1089/jmf.2006.1209
   Radi R, 2013, ACCOUNTS CHEM RES, V46, P550, DOI 10.1021/ar300234c
   Rajasekar P, 2007, EXP DIABETES RES, DOI 10.1155/2007/72741
   RECKNAGEL RO, 1984, METHOD ENZYMOL, V105, P331
   Ribeiro RT, 2016, CURR DIABETES REV, V12, P14, DOI 10.2174/1573399811666150701143112
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Samson SL, 2014, ENDOCRIN METAB CLIN, V43, P1, DOI 10.1016/j.ecl.2013.09.009
   Sherling DH, 2017, J CARDIOVASC PHARM T, V22, P365, DOI 10.1177/1074248416686187
   Shilling M, 2013, J MED FOOD, V16, P1079, DOI 10.1089/jmf.2012.0303
   Softic S, 2016, DIGEST DIS SCI, V61, P1282, DOI 10.1007/s10620-016-4054-0
   Swinburn B, 2009, AM J CLIN NUTR, V90, P1453, DOI 10.3945/ajcn.2009.28595
   Swinburn BA, 2011, LANCET, V378, P804, DOI 10.1016/S0140-6736(11)60813-1
   Thirunavukkarasu V, 2004, EXP DIABESITY RES, V5, P237, DOI 10.1080/154386090506148
   Unnikrishnan Ranjit, 2012, Indian J Endocrinol Metab, V16, P528, DOI 10.4103/2230-8210.98004
   Urakawa H, 2003, J CLIN ENDOCR METAB, V88, P4673, DOI 10.1210/jc.2003-030202
   Vetter SW, 2015, ADV CLIN CHEM, V72, P205, DOI 10.1016/bs.acc.2015.07.005
   Yildirim OG, 2019, TOXICOL MECH METHOD, V29, P224, DOI 10.1080/15376516.2018.1543745
   Zhang QB, 2009, J PROTEOME RES, V8, P754, DOI 10.1021/pr800858h
NR 53
TC 5
Z9 5
U1 0
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD APR
PY 2023
VL 114
AR 109272
DI 10.1016/j.jnutbio.2023.109272
EA FEB 2023
PG 11
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA C9LE7
UT WOS:000965042300001
PM 36681309
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Salazar, J
   Duran, P
   Garrido, B
   Parra, H
   Hernández, M
   Cano, C
   Añez, R
   García-Pacheco, H
   Cubillos, G
   Vasquez, N
   Chacin, M
   Bermúdez, V
AF Salazar, Juan
   Duran, Pablo
   Garrido, Bermary
   Parra, Heliana
   Hernandez, Marlon
   Cano, Climaco
   Anez, Roberto
   Garcia-Pacheco, Henry
   Cubillos, Gabriel
   Vasquez, Neidalis
   Chacin, Maricarmen
   Bermudez, Valmore
TI Weight Regain after Metabolic Surgery: Beyond the Surgical Failure
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE metabolic surgery; obesity; complications; metabolic syndrome; weight
ID ROUX-EN-Y; TRANSORAL OUTLET REDUCTION; POST-BARIATRIC SURGERY;
   MALADAPTIVE EATING PATTERNS; ARGON PLASMA COAGULATION; GASTRIC BYPASS
   PATIENTS; QUALITY-OF-LIFE; SLEEVE GASTRECTOMY; PHYSICAL-ACTIVITY;
   RISK-FACTORS
AB Patients undergoing metabolic surgery have factors ranging from anatomo-surgical, endocrine metabolic, eating patterns and physical activity, mental health and psychological factors. Some of the latter can explain the possible pathophysiological neuroendocrine, metabolic, and adaptive mechanisms that cause the high prevalence of weight regain in postbariatric patients. Even metabolic surgery has proven to be effective in reducing excess weight in patients with obesity; some of them regain weight after this intervention. In this vein, several studies have been conducted to search factors and mechanisms involved in weight regain, to stablish strategies to manage this complication by combining metabolic surgery with either lifestyle changes, behavioral therapies, pharmacotherapy, endoscopic interventions, or finally, surgical revision. The aim of this revision is to describe certain aspects and mechanisms behind weight regain after metabolic surgery, along with preventive and therapeutic strategies for this complication.
C1 [Salazar, Juan; Duran, Pablo; Garrido, Bermary; Parra, Heliana; Hernandez, Marlon; Cano, Climaco] Univ Zulia, Endocrine & Metab Dis Res Ctr, Sch Med, Maracaibo 4004, Venezuela.
   [Anez, Roberto] Hosp Quironsalud, Dept Endocrinol & Nutr, Madrid 28009, Spain.
   [Garcia-Pacheco, Henry] Univ Zulia, Hosp Gen Sur, Fac Med, Dept Cirugia, Maracaibo 4004, Venezuela.
   [Garcia-Pacheco, Henry] Unidad Cirugia Obes & Metab UCOM, Maracaibo 4004, Venezuela.
   [Cubillos, Gabriel; Vasquez, Neidalis] Clin Obes & Envejecimiento SAS, Bogota 110111, Colombia.
   [Chacin, Maricarmen; Bermudez, Valmore] Univ Simon Bolivar, Fac Ciencias Salud, Barranquilla 080001, Colombia.
   [Chacin, Maricarmen; Bermudez, Valmore] Univ Simon Bolivar, Ctr Invest Ciencias Vida, Barranquilla 080001, Colombia.
C3 quironsalud Group
RP Salazar, J (corresponding author), Univ Zulia, Endocrine & Metab Dis Res Ctr, Sch Med, Maracaibo 4004, Venezuela.; Bermúdez, V (corresponding author), Univ Simon Bolivar, Fac Ciencias Salud, Barranquilla 080001, Colombia.; Bermúdez, V (corresponding author), Univ Simon Bolivar, Ctr Invest Ciencias Vida, Barranquilla 080001, Colombia.
EM jjsv18@gmail.com
RI Duran, Pablo/AAW-6866-2020; Bermudez, Valmore/HLH-6291-2023; Bermudez,
   Valmore/E-3517-2018
OI Vasquez Batiz, Neidalis Mirlet/0000-0003-0182-9614; Parra,
   Heliana/0000-0002-6604-4212; Bermudez, Valmore/0000-0003-1880-8887;
   Garrido, Bermary/0000-0002-5522-7697; Hernandez,
   Marlon/0000-0001-9902-7438; Cubillos, Gabriel/0000-0001-6765-4891;
   Duran, Pablo/0000-0002-8030-1780
FU Universidad Simon Bolvar. Vicerrectora de Investigacin
FX No Statement Available
CR Adams RC, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092086
   Afshin A, 2017, NEW ENGL J MED, V377, P13, DOI 10.1056/NEJMoa1614362
   Ahima RS, 2006, DIABETES, V55, pS145, DOI 10.2337/db06-S018
   Ahn SM, 2020, J OBES METAB SYNDR, V29, P4
   Al-Khyatt W, 2017, OBES SURG, V27, P1446, DOI 10.1007/s11695-016-2500-x
   Al-Massadi O, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20163905
   Alcaro A, 2007, BRAIN RES REV, V56, P283, DOI 10.1016/j.brainresrev.2007.07.014
   Allison KC, 2006, OBESITY, V14, p77S, DOI 10.1038/oby.2006.286
   Alvarez V, 2016, NUTRITION, V32, P303, DOI 10.1016/j.nut.2015.08.023
   American Psychiatric Association (APA), 2013, Diagnostic and Statistical Manual of Mental Disorders, V5th ed
   Andalib A, 2021, SURG ENDOSC, V35, P4644, DOI 10.1007/s00464-020-07891-z
   Anderson WA, 2007, OBESITY, V15, P1455, DOI 10.1038/oby.2007.174
   Appleyard SM, 2005, J NEUROSCI, V25, P3578, DOI 10.1523/JNEUROSCI.4177-04.2005
   Athanasiadis DI, 2021, SURG ENDOSC, V35, P4069, DOI 10.1007/s00464-021-08329-w
   Ballantyne GH, 2006, OBES SURG, V16, P795, DOI 10.1381/096089206777346619
   Ferraz AAB, 2014, OBES SURG, V24, P2, DOI 10.1007/s11695-013-1055-3
   Baretta GAP, 2015, OBES SURG, V25, P72, DOI 10.1007/s11695-014-1363-2
   Ben Amor I, 2020, OBES SURG, V30, P2723, DOI 10.1007/s11695-020-04560-x
   Berthoud HR, 2008, ANNU REV PSYCHOL, V59, P55, DOI 10.1146/annurev.psych.59.103006.093551
   Blaszczak Alecia M, 2020, Immunometabolism, V2, DOI 10.20900/immunometab20200023
   Blomain Erik Scott, 2013, ISRN Obes, V2013, P210524, DOI 10.1155/2013/210524
   Blundell JE, 2011, NUTR BULL, V36, P356, DOI 10.1111/j.1467-3010.2011.01911.x
   Bohdjalian A, 2010, OBES SURG, V20, P535, DOI 10.1007/s11695-009-0066-6
   Bradley LE, 2017, OBES SURG, V27, P586, DOI 10.1007/s11695-016-2337-3
   Bradley LE, 2016, OBES SURG, V26, P2433, DOI 10.1007/s11695-016-2125-0
   Brunaldi VO, 2020, GASTROINTEST ENDOSC, V92, P97, DOI 10.1016/j.gie.2020.03.3757
   Buchwald H, 2004, JAMA-J AM MED ASSOC, V292, P1724, DOI 10.1001/jama.292.14.1724
   Buchwald H, 2013, OBES SURG, V23, P427, DOI 10.1007/s11695-012-0864-0
   Cambi MPC, 2021, OBES SURG, V31, P1290, DOI 10.1007/s11695-020-05164-1
   Cambi MPC, 2015, ABCD-ARQ BRAS CIR DI, V28, P40, DOI 10.1590/S0102-67202015000100011
   Carrodeguas Lester, 2005, Surg Obes Relat Dis, V1, P467, DOI 10.1016/j.soard.2005.07.003
   Castañeda TR, 2010, FRONT NEUROENDOCRIN, V31, P44, DOI 10.1016/j.yfrne.2009.10.008
   Chan JL, 2008, J CLIN ENDOCR METAB, V93, P2819, DOI 10.1210/jc.2008-0056
   Chan JL, 2006, OBESITY, V14, P194, DOI 10.1038/oby.2006.25
   Cheung CK, 2013, GUT LIVER, V7, P505, DOI 10.5009/gnl.2013.7.5.505
   Christou NV, 2006, ANN SURG, V244, P734, DOI 10.1097/01.sla.0000217592.04061.d5
   Colles SL, 2008, OBESITY, V16, P615, DOI 10.1038/oby.2007.101
   Cornier MA, 2022, AM J MANAG CARE, V28, pS288, DOI 10.37765/ajmc.2022.89292
   Cornier MA, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006310
   Cota D, 2003, J CLIN INVEST, V112, P423, DOI 10.1172/JCI17725
   Crowley VEF, 2008, ANN CLIN BIOCHEM, V45, P245, DOI 10.1258/acb.2007.007193
   CUCCHI SGD, 1995, ANN SURG, V221, P387, DOI 10.1097/00000658-199504000-00009
   Currie PJ, 2005, AM J PHYSIOL-REG I, V289, pR353, DOI 10.1152/ajpregu.00756.2004
   Date Y, 2002, GASTROENTEROLOGY, V123, P1120, DOI 10.1053/gast.2002.35954
   De Moura DTH, 2019, EXPERT REV ENDOCRINO, V14, P97, DOI 10.1080/17446651.2019.1571907
   de Quadros LG, 2020, OBES SURG, V30, P1904, DOI 10.1007/s11695-020-04414-6
   de Zwaan M, 2003, COMPR PSYCHIAT, V44, P428, DOI 10.1016/S0010-440X(03)00092-0
   DelParigi A, 2004, INT J OBESITY, V28, P370, DOI 10.1038/sj.ijo.0802558
   Dhindsa BS, 2020, ENDOSC INT OPEN, V08, pE1332, DOI 10.1055/a-1214-5822
   Di Angelantonio E, 2016, LANCET, V388, P776, DOI 10.1016/S0140-6736(16)30175-1
   Disse E, 2010, PHYSIOL BEHAV, V101, P277, DOI 10.1016/j.physbeh.2010.05.017
   docplayer, Actualizacion del Consenso Argentino de Nutricion en Cirugia Bariatrica
   Edgerton C, 2021, J GASTROINTEST SURG, V25, P369, DOI 10.1007/s11605-020-04880-4
   Eisenberg D, 2022, SURG OBES RELAT DIS, V18, P1345, DOI 10.1016/j.soard.2022.08.013
   El Ansari W, 2021, OBES SURG, V31, P1755, DOI 10.1007/s11695-020-05160-5
   Elfhag K, 2005, OBES REV, V6, P67, DOI 10.1111/j.1467-789X.2005.00170.x
   Engström BE, 2007, INT J OBESITY, V31, P476, DOI 10.1038/sj.ijo.0803440
   Escrivá F, 2007, J ENDOCRINOL, V194, P131, DOI 10.1677/joe.1.07043
   Faria SL, 2009, OBES SURG, V19, P856, DOI 10.1007/s11695-009-9842-6
   Farr OM, 2015, CURR OPIN ENDOCRINOL, V22, P353, DOI 10.1097/MED.0000000000000184
   Filho A.J.B., 2007, J. Soc. Laparoendosc. Surg, V10, P326
   Flier JS, 2000, J CLIN INVEST, V105, P859, DOI 10.1172/JCI9725
   Foster A, 2003, J GASTROINTEST SURG, V7, P750, DOI 10.1016/S1091-255X(03)00092-1
   Freire RH, 2012, NUTRITION, V28, P53, DOI 10.1016/j.nut.2011.01.011
   Fulton S, 2000, SCIENCE, V287, P125, DOI 10.1126/science.287.5450.125
   Gallé F, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0241336
   Garcia JM, 2010, AM J NURS, V110, P26, DOI 10.1097/01.NAJ.0000390519.83887.02
   Gearhardt AN, 2011, ARCH GEN PSYCHIAT, V68, P808, DOI 10.1001/archgenpsychiatry.2011.32
   Contreras AG, 2020, OBES SURG, V30, P687, DOI 10.1007/s11695-019-04242-3
   Gletsu-Miller N, 2013, ADV NUTR, V4, P506, DOI 10.3945/an.113.004341
   Gomes M., 2024, Obes. Med, V45, P100528
   Guijarro A, 2008, ANN SURG, V247, P779, DOI 10.1097/SLA.0b013e318166fd5f
   Guijarro A, 2007, AM J PHYSIOL-REG I, V293, pR1474, DOI 10.1152/ajpregu.00171.2007
   Guijarro A, 2006, CURR OPIN CLIN NUTR, V9, P423, DOI 10.1097/01.mco.0000232903.04910.7b
   Gutt S, 2019, EXPERT OPIN PHARMACO, V20, P939, DOI 10.1080/14656566.2019.1583746
   Hanipah ZN, 2018, SURG OBES RELAT DIS, V14, P93, DOI 10.1016/j.soard.2017.10.002
   Heneghan HM, 2012, SURG OBES RELAT DIS, V8, P408, DOI 10.1016/j.soard.2011.09.010
   Hernandez Julian, 2016, Ann Surg Innov Res, V10, P3, DOI 10.1186/s13022-015-0021-2
   Heymsfield SB, 2017, NEW ENGL J MED, V376, P254, DOI 10.1056/NEJMra1514009
   Himes SM, 2015, OBES SURG, V25, P922, DOI 10.1007/s11695-015-1611-0
   Hume DJ, 2016, AM J CLIN NUTR, V103, P1389, DOI 10.3945/ajcn.115.127753
   Hutch CR, 2017, ENDOCRINOLOGY, V158, P4139, DOI 10.1210/en.2017-00564
   Istfan NW, 2021, J CLIN ENDOCR METAB, V106, P251, DOI 10.1210/clinem/dgaa702
   Istfan NW, 2020, OBESITY, V28, P1023, DOI 10.1002/oby.22786
   Jabbour G, 2021, OBES SURG, V31, P1767, DOI 10.1007/s11695-020-05182-z
   Jackman MR, 2008, AM J PHYSIOL-REG I, V294, pR1117, DOI 10.1152/ajpregu.00808.2007
   James W P T, 2002, Obes Rev, V3, P139, DOI 10.1046/j.1467-789X.2002.00063.x
   Janmohammadi P, 2019, OBES SURG, V29, P1040, DOI 10.1007/s11695-018-03663-w
   Jaruvongvanich V, 2020, GASTROINTEST ENDOSC, V92, P1164, DOI 10.1016/j.gie.2020.07.013
   Jensen AB, 2023, OBES SURG, V33, P1017, DOI 10.1007/s11695-023-06484-8
   Jester L, 1996, OBES SURG, V6, P412, DOI 10.1381/096089296765556476
   Jirapinyo P, 2020, GASTROINTEST ENDOSC, V91, P1282, DOI 10.1016/j.gie.2020.01.036
   Jirapinyo P, 2020, GASTROINTEST ENDOSC, V91, P1067, DOI 10.1016/j.gie.2019.11.044
   Jirapinyo P, 2020, GASTROINTEST ENDOSC, V91, P1078, DOI 10.1016/j.gie.2019.12.036
   Jirapinyo P, 2018, ENDOSCOPY, V50, P371, DOI 10.1055/s-0043-122380
   Jirapinyo P, 2018, OBES SURG, V28, P615, DOI 10.1007/s11695-017-2913-1
   Jo YH, 2005, NEURON, V48, P1055, DOI 10.1016/j.neuron.2005.10.021
   Johnstone AM, 2004, EUR J ENDOCRINOL, V150, P185, DOI 10.1530/eje.0.1500185
   Juchacz K, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020532
   Kaineder K, 2017, INT J OBESITY, V41, P1263, DOI 10.1038/ijo.2017.98
   Karlsson J, 2007, INT J OBESITY, V31, P1248, DOI 10.1038/sj.ijo.0803573
   Keith CJ, 2018, SURG ENDOSC, V32, P2232, DOI 10.1007/s00464-017-5913-2
   Kermansaravi M, 2021, UPDATES SURG, V73, P663, DOI 10.1007/s13304-020-00961-w
   Kinasz KR, 2017, BIOL PSYCHIAT, V81, pE73, DOI 10.1016/j.biopsych.2017.02.1177
   Kissileff HR, 2012, AM J CLIN NUTR, V95, P309, DOI 10.3945/ajcn.111.012385
   Koch JE, 2001, NUTR NEUROSCI, V4, P179, DOI 10.1080/1028415X.2001.11747361
   Kofman MD, 2010, OBESITY, V18, P1938, DOI 10.1038/oby.2010.27
   Korner J, 2009, INT J OBESITY, V33, P786, DOI 10.1038/ijo.2009.79
   Kozlowska L, 2004, ENDOCRINE, V24, P147, DOI 10.1385/ENDO:24:2:147
   Kraschnewski JL, 2010, INT J OBESITY, V34, P1644, DOI 10.1038/ijo.2010.94
   Lassale C, 2018, EUR HEART J, V39, P397, DOI 10.1093/eurheartj/ehx448
   Lautenbach A, 2022, OBES SURG, V32, P3280, DOI 10.1007/s11695-022-06211-9
   le Roux CW, 2007, ANN SURG, V246, P780, DOI 10.1097/SLA.0b013e3180caa3e3
   le Roux CW, 2006, ANN SURG, V243, P108, DOI 10.1097/01.sla.0000183349.16877.84
   Lee MJ, 2007, AM J PHYSIOL-ENDOC M, V292, pE858, DOI 10.1152/ajpendo.00439.2006
   Li SY, 2021, DIABET METAB SYND OB, V14, P575, DOI 10.2147/DMSO.S295162
   Lindgren E, 2018, FRONT BIOSCI-LANDMRK, V23, P811, DOI 10.2741/4618
   Bastos ECL, 2013, ABCD-ARQ BRAS CIR DI, V26, P26, DOI 10.1590/S0102-67202013000600007
   Livhits M, 2011, OBES RES CLIN PRACT, V5, pE258, DOI 10.1016/j.orcp.2011.03.004
   Livingstone MBE, 2022, J NUTR, V152, P2319, DOI 10.1093/jn/nxac164
   da Silva FBL, 2016, NUTRITION, V32, P1250, DOI 10.1016/j.nut.2016.01.018
   MacLean PS, 2015, OBES REV, V16, P45, DOI 10.1111/obr.12255
   MacLean PS, 2011, AM J PHYSIOL-REG I, V301, pR581, DOI 10.1152/ajpregu.00755.2010
   MacLean PS, 2006, AM J PHYSIOL-REG I, V290, pR1577, DOI 10.1152/ajpregu.00810.2005
   MacLean PS, 2004, AM J PHYSIOL-REG I, V287, pR1306, DOI 10.1152/ajpregu.00463.2004
   Madsbad S, 2014, DIABETES, V63, P3172, DOI 10.2337/db14-0935
   Magro DO, 2008, OBES SURG, V18, P648, DOI 10.1007/s11695-007-9265-1
   Matias I, 2006, INT J OBESITY, V30, pS7, DOI 10.1038/sj.ijo.0803271
   Mauro MFFP, 2019, OBES REV, V20, P1413, DOI 10.1111/obr.12907
   Meguid MM, 2008, NUTRITION, V24, P832, DOI 10.1016/j.nut.2008.06.027
   Moizé VL, 2010, OBES SURG, V20, P1133, DOI 10.1007/s11695-010-0160-9
   Moon RC, 2018, OBES SURG, V28, P2737, DOI 10.1007/s11695-018-3229-5
   Morioka T., 2016, Musculoskeletal Disease Associated with Diabetes Mellitus, DOI DOI 10.1007/978-4-431-55720-3_14
   Mulla CM, 2018, ANN NY ACAD SCI, V1411, P53, DOI 10.1111/nyas.13409
   Murphy KG, 2006, ENDOCR REV, V27, P719, DOI 10.1210/er.2006-0028
   Nakazato M, 2001, NATURE, V409, P194, DOI 10.1038/35051587
   Naleid AM, 2005, PEPTIDES, V26, P2274, DOI 10.1016/j.peptides.2005.04.025
   Noria SF, 2023, CURR DIABETES REP, V23, P31, DOI 10.1007/s11892-023-01498-z
   Nuijten MAH, 2021, OBES SURG, V31, P1120, DOI 10.1007/s11695-020-05009-x
   O'Brien CS, 2013, OBES SURG, V23, P1294, DOI 10.1007/s11695-013-0917-z
   O'Neil PM, 2018, LANCET, V392, P637, DOI 10.1016/S0140-6736(18)31773-2
   Odom J, 2010, OBES SURG, V20, P349, DOI 10.1007/s11695-009-9895-6
   Owyang C, 2011, J NEUROGASTROENTEROL, V17, P338, DOI 10.5056/jnm.2011.17.4.338
   Pajecki Denis, 2013, Rev. Col. Bras. Cir., V40, P191
   Pallati PK, 2014, SURG OBES RELAT DIS, V10, P502, DOI 10.1016/j.soard.2013.07.018
   Pan WH, 2008, ASIA PAC J CLIN NUTR, V17, P370
   Park Hyeong-Kyu, 2014, F1000Prime Rep, V6, P73, DOI 10.12703/P6-73
   Patel LY, 2017, SURG ENDOSC, V31, P2667, DOI 10.1007/s00464-016-5281-3
   Patel S, 2011, OBES SURG, V21, P1209, DOI 10.1007/s11695-010-0234-8
   Paul L, 2017, CURR OPIN PSYCHIATR, V30, P474, DOI 10.1097/YCO.0000000000000359
   Peeters TL, 2005, GUT, V54, P1638, DOI 10.1136/gut.2004.062604
   Perry B, 2012, NUTR DIABETES, V2, DOI 10.1038/nutd.2011.21
   Pizato N, 2017, NUTRIENTS, V9, DOI 10.3390/nu9121322
   Puzziferri N, 2014, JAMA-J AM MED ASSOC, V312, P934, DOI 10.1001/jama.2014.10706
   Relly R, 2021, SURG ENDOSC, V35, P6846, DOI 10.1007/s00464-020-08190-3
   Romanova IV, 2004, J AM COLL SURGEONS, V199, P887, DOI 10.1016/j.jamcollsurg.2004.07.013
   Rosenbaum M, 2000, AM J CLIN NUTR, V71, P1421
   Rosenbaum M, 2008, J CLIN INVEST, V118, P2583, DOI 10.1172/JCI35055
   Rosenberger PH, 2011, OBES SURG, V21, P1564, DOI 10.1007/s11695-010-0283-z
   Roslin M, 2011, SURG ENDOSC, V25, P1926, DOI 10.1007/s00464-010-1489-9
   Rossmeislová L, 2013, DIABETES, V62, P1990, DOI 10.2337/db12-0986
   Runge TM, 2019, SURG OBES RELAT DIS, V15, P2045, DOI 10.1016/j.soard.2019.06.041
   Rusch MD, 2007, NUTR CLIN PRACT, V22, P41, DOI 10.1177/011542650702200141
   Rutledge T, 2011, OBES SURG, V21, P29, DOI 10.1007/s11695-009-9923-6
   Rye P, 2018, OBES SURG, V28, P3553, DOI 10.1007/s11695-018-3393-7
   Salehi M, 2011, DIABETES, V60, P2308, DOI 10.2337/db11-0203
   Samuel N, 2020, ANN ROY COLL SURG, V102, P54, DOI 10.1308/rcsann.2019.0100
   Santo MA, 2016, OBES SURG, V26, P919, DOI 10.1007/s11695-015-1908-z
   Saunders R, 2004, OBES SURG, V14, P98, DOI 10.1381/096089204772787374
   Schwartz J, 2016, OBES SURG, V26, P452, DOI 10.1007/s11695-015-1979-x
   Sepúlveda-Lizcano L, 2023, EUR J INVEST HEALTH, V13, P1505, DOI 10.3390/ejihpe13080110
   Shantavasinkula PC, 2016, SURG OBES RELAT DIS, V12, P1640, DOI 10.1016/j.soard.2016.08.028
   Sheets CS, 2015, OBES SURG, V25, P330, DOI 10.1007/s11695-014-1490-9
   Shimon O, 2018, OBES SURG, V28, P1724, DOI 10.1007/s11695-017-3086-7
   Sjöström L, 2004, NEW ENGL J MED, V351, P2683, DOI 10.1056/NEJMoa035622
   Snyder AG, 2009, OCHSNER J, V9, P144
   Stanford FC, 2017, SURG OBES RELAT DIS, V13, P491, DOI 10.1016/j.soard.2016.10.018
   Stewart F, 2016, OBES SURG, V26, P1203, DOI 10.1007/s11695-015-1873-6
   Storm Andrew C, 2017, Gastrointest Endosc Clin N Am, V27, P233, DOI 10.1016/j.giec.2016.12.007
   Sumithran P, 2013, CLIN SCI, V124, P231, DOI 10.1042/CS20120223
   Suzuki S, 2005, SURGERY, V138, P283, DOI 10.1016/j.surg.2005.05.013
   Switzer NJ, 2016, SURG CLIN N AM, V96, P827, DOI 10.1016/j.suc.2016.03.004
   Tak YJ, 2021, CURR OBES REP, V10, P14, DOI 10.1007/s13679-020-00422-w
   Tamboli RA, 2014, OBESITY, V22, P1617, DOI 10.1002/oby.20776
   Tettero OM, 2018, OBES SURG, V28, P3950, DOI 10.1007/s11695-018-3439-x
   Thompson CC, 2013, GASTROENTEROLOGY, V145, P129, DOI 10.1053/j.gastro.2013.04.002
   Tomiyama AJ, 2010, PSYCHOSOM MED, V72, P357, DOI 10.1097/PSY.0b013e3181d9523c
   Torbay N., 2019, J. Endocr. Soc, V3, pSAT, DOI [10.1210/js.2019-SAT-120, DOI 10.1210/JS.2019-SAT-120]
   Toth AT, 2018, CHILDREN-BASEL, V5, DOI 10.3390/children5090116
   Tsouristakis AI, 2019, OBES SURG, V29, P3698, DOI 10.1007/s11695-019-04111-z
   van Rossum CTM, 2002, INT J OBESITY, V26, P517, DOI 10.1038/sj.ijo.0801964
   Vargas EJ, 2018, SURG ENDOSC, V32, P252, DOI 10.1007/s00464-017-5671-1
   Varma S, 2017, SURG OBES RELAT DIS, V13, P1728, DOI 10.1016/j.soard.2017.06.004
   Velapati Saketh R, 2018, Curr Nutr Rep, V7, P329, DOI 10.1007/s13668-018-0243-0
   Weiner RA, 2007, OBES SURG, V17, P1297, DOI 10.1007/s11695-007-9232-x
   Wharton Sean, 2019, J Drug Assess, V8, P184, DOI 10.1080/21556660.2019.1678478
   Wharton S, 2019, CLIN OBES, V9, DOI 10.1111/cob.12323
   World Health Organization Regional Office for the Western Pacific, 2000, The Asia-Pacific perspective: redefining obesity and its treatment, P55
   World Health Organization (WHO), Obesity and overweight
   World Obesity Federation, 2023, WORLD OBESITY ATLAS
   World Obesity Federation Global Obesity Observatory, 2023, World obesity day atlases | obesity atlas
   Yabut JM, 2019, ENDOCR REV, V40, P1092, DOI 10.1210/er.2018-00283
   Yanos BR, 2015, OBES SURG, V25, P1364, DOI 10.1007/s11695-014-1536-z
   Yimcharoen P, 2011, SURG ENDOSC, V25, P3345, DOI 10.1007/s00464-011-1723-0
   Yu JH, 2012, DIABETES METAB J, V36, P391, DOI 10.4093/dmj.2012.36.6.391
   Zalesin KC, 2010, AM J LIFESTYLE MED, V4, P113, DOI 10.1177/1559827609351227
   Zhang Y, 2014, NUTRIENTS, V6, P5153, DOI 10.3390/nu6115153
   Zilberstein B, 2004, OBES SURG, V14, P802, DOI 10.1381/0960892041590926
NR 209
TC 2
Z9 2
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD FEB
PY 2024
VL 13
IS 4
AR 1143
DI 10.3390/jcm13041143
PG 22
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA JH2S5
UT WOS:001172214400001
PM 38398456
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Iafusco, D
   Franceschi, R
   Maguolo, A
   Nuzio, SG
   Crinò, A
   Delvecchio, M
   Iughetti, L
   Maffeis, C
   Calcaterra, V
   Manco, M
AF Iafusco, Dario
   Franceschi, Roberto
   Maguolo, Alice
   Nuzio, Salvatore Guercio
   Crino, Antonino
   Delvecchio, Maurizio
   Iughetti, Lorenzo
   Maffeis, Claudio
   Calcaterra, Valeria
   Manco, Melania
TI From Metabolic Syndrome to Type 2 Diabetes in Youth
SO CHILDREN-BASEL
LA English
DT Review
DE adolescents; insulin resistance; insulin secretion; youth; metabolic
   syndrome; obesity; oxidative stress; type 2 diabetes
ID IMPAIRED GLUCOSE-TOLERANCE; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   NORMAL-WEIGHT; POSITION STATEMENT; FATTY-ACIDS; CHILDREN; OBESITY; RISK;
   ADOLESCENTS
AB In the frame of metabolic syndrome, type 2 diabetes emerges along a continuum of the risk from the clustering of all its components, namely visceral obesity, high blood pressure and lipids, and impaired glucose homeostasis. Insulin resistance is the hallmark common to all the components and, in theory, is a reversible condition. Nevertheless, the load that this condition can exert on the beta-cell function at the pubertal transition is such as to determine its rapid and irreversible deterioration leading to plain diabetes. The aim of this review is to highlight, in the context of metabolic syndrome, age-specific risk factors that lead to type 2 diabetes onset in youth; resume age specific screening and diagnostic criteria; and anticipate potential for treatment. Visceral obesity and altered lipid metabolism are robust grounds for the development of the disease. Genetic differences in susceptibility to hampered beta-cell function in the setting of obesity and insulin resistance largely explain why some adolescents with obesity do develop diabetes at a young age and some others do not. Lifestyle intervention with a healthy diet and physical activity remains the pillar of the type 2 diabetes treatment in youth. As to the pharmacological management, metformin and insulin have failed to rescue beta-cell function and to ensure long-lasting glycemic control in youth. A new era might start with the approval for use in pediatric age of drugs largely prescribed in adults, such as dipeptidyl peptidase-4 and sodium-dependent glucose transport inhibitors, and of new weight-lowering drugs in the pipeline such as single and multiple agonists of the glucagon-like peptide 1 receptor. The latter drugs can have tremendous impact on the natural history of the disease. By treating diabetes, they will reduce the burden of all the metabolic abnormalities belonging to the syndrome while causing a tremendous weight loss hitherto never seen before.
C1 [Iafusco, Dario] Univ Campania L Vanvitelli, Reg Ctr Pediat Diabet, Dept Woman Child & Gen & Specialist Surg, I-80131 Naples, Italy.
   [Franceschi, Roberto] S Chiara Hosp Trento, Pediat Dept, APSS, I-38122 Trento, Italy.
   [Maguolo, Alice; Maffeis, Claudio] Univ Verona, Dept Surg Dent Pediat & Gynecol, Sect Pediat Diabet & Metab, I-37129 Verona, Italy.
   [Nuzio, Salvatore Guercio] S Maria della Speranza Hosp Battipaglia, Dept Womens & Childrens Hlth, Pediat Unit, I-84091 Salerno, Italy.
   [Crino, Antonino] Fdn Policlin Univ Agostino Gemelli IRCCS, Ctr Rare Dis & Congenital Defects, I-00168 Rome, Italy.
   [Delvecchio, Maurizio] AOU Policlin Bari, Giovanni XXIII Childrens Hosp, Metab Disorders & Diabet Unit, I-70124 Bari, Italy.
   [Iughetti, Lorenzo] Univ Modena & Reggio Emilia, Post Grad Sch Pediat, Dept Med & Surg Sci Mothers Children & Adults, I-41121 Modena, Italy.
   [Calcaterra, Valeria] Univ Pavia, Dept Internal Med, I-27100 Pavia, Italy.
   [Calcaterra, Valeria] V Buzzi Childrens Hosp, Pediat Dept, I-20154 Milan, Italy.
   [Manco, Melania] IRCCS, Bambino Gesu Childrens Hosp, Prevent & Predict Med Unit, I-00165 Rome, Italy.
C3 Universita della Campania Vanvitelli; University of Verona; Catholic
   University of the Sacred Heart; IRCCS Policlinico Gemelli; Universita di
   Modena e Reggio Emilia; University of Pavia; IRCCS Bambino Gesu
RP Manco, M (corresponding author), IRCCS, Bambino Gesu Childrens Hosp, Prevent & Predict Med Unit, I-00165 Rome, Italy.
EM melania.manco@opbg.net
RI Franceschi, Roberto/GRR-6210-2022; Maffeis, Claudio/AAG-5347-2020;
   Calcaterra, Valeria/AAB-7563-2022; Manco, Melania/M-1058-2013; Iughetti,
   Lorenzo/I-4602-2014; Delvecchio, Maurizio/K-8762-2012; maguolo,
   alice/HHS-0886-2022
OI Manco, Melania/0000-0002-6581-975X; CALCATERRA,
   VALERIA/0000-0002-2137-5974; Franceschi, Roberto/0000-0002-2230-7148;
   Iughetti, Lorenzo/0000-0003-0370-7872; Delvecchio,
   Maurizio/0000-0002-1528-0012; maguolo, alice/0000-0002-8921-2012;
   Maffeis, Claudio/0000-0002-3563-4404
FU Italian Ministry of Health [EU_PNRR M6C2]
FX M.M. received funds from the Italian Ministry of Health ("ricerca 5 x
   mille 2023", "ricerca corrente"; and "EU-Next Generation EU_PNRR M6C2-
   Investimento 2.1 Valorizzazione e potenziamento della ricerca biomedica
   del SSN").
CR Agudelo GM, 2014, METAB SYNDR RELAT D, V12, P202, DOI 10.1089/met.2013.0127
   Al-Hamad D, 2017, TRANSL PEDIATR, V6, P397, DOI 10.21037/tp.2017.10.02
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Almgren P, 2011, DIABETOLOGIA, V54, P2811, DOI 10.1007/s00125-011-2267-5
   Amer Diabet Assoc, 2020, DIABETES CARE, V43, pS14, DOI 10.2337/dc20-S002
   Amer Diabet Assoc, 2009, DIABETES CARE, V32, pS62, DOI [10.2337/dc09-S062, 10.2337/dc10-s062]
   Amer Diabet Assoc Professional Pra, 2022, DIABETES CARE, V45, pS17, DOI 10.2337/dc22-S002
   Amer Diabet Assoc Professional Pra, 2022, DIABETES CARE, V45, pS208, DOI 10.2337/dc22-S014
   Andellini M, 2023, ACTA DIABETOL, V60, P9, DOI 10.1007/s00592-022-01963-3
   Andes LJ, 2020, JAMA PEDIATR, V174, DOI 10.1001/jamapediatrics.2019.4498
   Arslanian S, 2018, DIABETES CARE, V41, P2648, DOI 10.2337/dci18-0052
   Bacha F, 2018, HORM RES PAEDIAT, V89, P47, DOI 10.1159/000481687
   Balkhiyarova Z, 2022, HUM MOL GENET, V31, P816, DOI 10.1093/hmg/ddab287
   Barlow SE, 2007, PEDIATRICS, V120, pS164, DOI 10.1542/peds.2007-2329C
   Barroso I, 2003, PLOS BIOL, V1, P41, DOI 10.1371/journal.pbio.0000020
   Bensignor MO, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.1043650
   Bergman M, 2018, DIABETES-METAB RES, V34, DOI 10.1002/dmrr.2992
   Bianchi M, 2019, FRONT GENET, V10, DOI 10.3389/fgene.2019.01050
   Blake DR, 2004, DIABETES, V53, P2095, DOI 10.2337/diabetes.53.8.2095
   Boney CM, 2005, PEDIATRICS, V115, pE290, DOI 10.1542/peds.2004-1808
   Brar PC, 2019, ANN PEDIATR ENDOCRIN, V24, P71, DOI 10.6065/apem.2019.24.2.71
   Bush H, 2017, CHILDREN-BASEL, V4, DOI 10.3390/children4060048
   Candler TP, 2018, DIABETIC MED, V35, P737, DOI 10.1111/dme.13609
   Chen ME, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1023-3
   Chesser H, 2024, J DIABETES SCI TECHN, V18, P911, DOI 10.1177/19322968221139873
   Colberg SR, 2016, DIABETES CARE, V39, P2065, DOI 10.2337/dc16-1728
   Colberg SR, 2010, DIABETES CARE, V33, P2692, DOI [10.2337/dc10-1548, 10.2337/dc10-9990]
   Copeland KC, 2013, PEDIATRICS, V131, P364, DOI 10.1542/peds.2012-3494
   Cruz Martha L, 2004, Curr Diab Rep, V4, P53, DOI 10.1007/s11892-004-0012-x
   Dabelea D, 2011, DIABETOLOGIA, V54, P535, DOI 10.1007/s00125-010-1982-7
   Davidson KW, 2021, JAMA-J AM MED ASSOC, V326, P736, DOI 10.1001/jama.2021.12531
   de Ferranti SD, 2004, CIRCULATION, V110, P2494, DOI 10.1161/01.CIR.0000145117.40114.C7
   Deckelbaum RJ, 2001, OBES RES, V9, p239S, DOI 10.1038/oby.2001.125
   Delvecchio M, 2017, J CLIN ENDOCR METAB, V102, P1826, DOI 10.1210/jc.2016-2490
   Demirbag R, 2005, SCAND CARDIOVASC J, V39, P172, DOI 10.1080/14017430510035862
   Di Bonito P, 2010, J ENDOCRINOL INVEST, V33, P806, DOI [10.1007/BF03350346, 10.3275/6905]
   Dias I, 2015, MED SCI SPORT EXER, V47, P2636, DOI 10.1249/MSS.0000000000000705
   Ding W, 2018, BMC MED GENET, V19, DOI 10.1186/s12881-018-0553-5
   Divers J, 2020, MMWR-MORBID MORTAL W, V69, P161, DOI 10.15585/mmwr.mm6906a3
   Elliott HR, 2019, DIABETOLOGIA, V62, P2171, DOI 10.1007/s00125-019-05011-8
   Ezzati M, 2017, LANCET, V390, P2627, DOI [10.1016/S0140-6736(17)32129-3, 10.1016/s0140-6736(17)32129-3]
   Fajans SS, 2011, DIABETES CARE, V34, P1878, DOI 10.2337/dc11-0035
   Fedewa MV, 2014, PEDIATRICS, V133, pE163, DOI 10.1542/peds.2013-2718
   Friedrichsen M, 2021, DIABETES OBES METAB, V23, P754, DOI 10.1111/dom.14280
   Friend A, 2013, METAB SYNDR RELAT D, V11, P71, DOI 10.1089/met.2012.0122
   Garonzi C, 2022, HORM RES PAEDIAT, DOI 10.1159/000528342
   Giannini C, 2022, INT J OBESITY, V46, P1694, DOI 10.1038/s41366-022-01164-6
   Giuliana V., 2017, G ITAL DIABETOL META, V37, P213
   Goran MI, 2003, J CLIN ENDOCR METAB, V88, P1417, DOI 10.1210/jc.2002-021442
   Graf C, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20246159
   Greco AV, 2002, DIABETES, V51, P144, DOI 10.2337/diabetes.51.1.144
   Hani EH, 1998, DIABETOLOGIA, V41, P1511, DOI 10.1007/s001250051098
   Harsunen M, 2023, DIABETOLOGIA, V66, P438, DOI 10.1007/s00125-022-05834-y
   Huebschmann AG, 2019, DIABETOLOGIA, V62, P1761, DOI 10.1007/s00125-019-4939-5
   Iafusco D., 2014, G ITAL DIABETOL META, V34, P117
   Inge TH, 2019, NEW ENGL J MED, V380, P2136, DOI 10.1056/NEJMoa1813909
   Inge TH, 2018, JAMA PEDIATR, V172, P452, DOI 10.1001/jamapediatrics.2017.5763
   Jensen ET, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-0997-1
   Kaar JL, 2020, PEDIATR DIABETES, V21, DOI 10.1111/pedi.12976
   Kander MC, 2017, J CELL MOL MED, V21, P1024, DOI 10.1111/jcmm.13038
   Kelly Aaron S, 2022, NEJM Evid, V1, DOI 10.1056/evidoa2200014
   Kim JY, 2013, DIABETES CARE, V36, P1681, DOI 10.2337/dc12-1861
   Kim JA, 2019, ENDOCRINOL METAB, V34, P406, DOI 10.3803/EnM.2019.34.4.406
   Kufe CN, 2022, EUR J ENDOCRINOL, V186, P523, DOI 10.1530/EJE-21-0527
   Laffel LMB, 2018, DIABETIC MED, V35, P1096, DOI 10.1111/dme.13629
   Lee SH, 2022, DIABETES METAB J, V46, P15, DOI 10.4093/dmj.2021.0280
   Magge SN, 2017, PEDIATRICS, V140, DOI 10.1542/peds.2017-1603
   Mahajan A, 2018, NAT GENET, V50, P1505, DOI 10.1038/s41588-018-0241-6
   Malik IHO, 2022, OBESITY, V30, P1718, DOI 10.1002/oby.23521
   Manco M, 2008, INT J OBESITY, V32, P381, DOI 10.1038/sj.ijo.0803711
   Manco M, 2004, DIABETES OBES METAB, V6, P402, DOI 10.1111/j.1462-8902.2004.00356.x
   Mangione CM, 2022, JAMA-J AM MED ASSOC, V328, P963, DOI 10.1001/jama.2022.14543
   Marseglia L, 2015, INT J MOL SCI, V16, P378, DOI 10.3390/ijms16010378
   Martos-Moreno GA, 2006, EUR J ENDOCRINOL, V155, P429, DOI 10.1530/eje.1.02227
   Mayer-Davis EJ, 2018, PEDIATR DIABETES, V19, P7, DOI 10.1111/pedi.12773
   McGavock J, 2015, CURR DIABETES REP, V15, DOI 10.1007/s11892-014-0568-z
   Morandi A, 2016, J CLIN ENDOCR METAB, V101, P4244, DOI 10.1210/jc.2016-2432
   Newton KP, 2016, JAMA PEDIATR, V170, DOI 10.1001/jamapediatrics.2016.1971
   Okuyaz C, 2012, PEDIATR NEUROL, V47, P423, DOI 10.1016/j.pediatrneurol.2012.08.003
   Paltoglou G, 2017, ENDOCRINE, V55, P925, DOI 10.1007/s12020-017-1227-3
   Paltoglou G, 2015, PEDIATR RES, V78, P158, DOI 10.1038/pr.2015.85
   Papamargaritis D, 2024, CARDIOVASC RES, V119, P2825, DOI 10.1093/cvr/cvac176
   Pedicelli S, 2022, PEDIATR OBES, V17, DOI 10.1111/ijpo.12900
   Peruzzi B, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24010447
   Pinhas-Hamiel O, 2007, PEDIATR DIABETES, V8, P16, DOI 10.1111/j.1399-5448.2007.00330.x
   Raschke S, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/320724
   Sarhangi N, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-69363-7
   Savoye M, 2014, DIABETES CARE, V37, P317, DOI 10.2337/dc13-1571
   Shah AS, 2022, PEDIATR DIABETES, V23, P872, DOI 10.1111/pedi.13409
   Shaibi GQ, 2006, INT J OBESITY, V30, P45, DOI 10.1038/sj.ijo.0803171
   Shaw JE, 2000, DIABETES CARE, V23, pB5
   SILVERMAN BL, 1995, DIABETES CARE, V18, P611, DOI 10.2337/diacare.18.5.611
   Smart CE, 2018, PEDIATR DIABETES, V19, P136, DOI 10.1111/pedi.12738
   Smart CE, 2014, PEDIATR DIABETES, V15, P135, DOI 10.1111/pedi.12175
   Son JW, 2020, DIABETES METAB J, V44, P802
   Stoner L, 2020, J PEDIATR-US, V217, P39, DOI 10.1016/j.jpeds.2019.09.076
   Styne DM, 2017, J CLIN ENDOCR METAB, V102, P709, DOI 10.1210/jc.2016-2573
   Tamborlane WV, 2018, PEDIATR DIABETES, V19, P640, DOI 10.1111/pedi.12616
   TODAY Study Group, 2010, Int J Obes (Lond), V34, P217, DOI 10.1038/ijo.2009.195
   Todd JN, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1025-1
   United States Food and Drug Administration, 2022, FDA APPR TREATM CHRO
   Valerio G, 2018, ITAL J PEDIATR, V44, DOI 10.1186/s13052-018-0525-6
   Vassy JL, 2012, DIABETOLOGIA, V55, P2604, DOI 10.1007/s00125-012-2637-7
   Verma Manu, 2022, Metabolism, V133, P155240, DOI 10.1016/j.metabol.2022.155240
   Vijayakumar P, 2017, DIABETES CARE, V40, P16, DOI 10.2337/dc16-1358
   von Frankenberg AD, 2017, ARCH ENDOCRIN METAB, V61, P614, DOI 10.1590/2359-3997000000316
   Weghuber D, 2022, NEW ENGL J MED, V387, P2245, DOI 10.1056/NEJMoa2208601
   Weiss R, 2004, NEW ENGL J MED, V350, P2362, DOI 10.1056/NEJMoa031049
   Wittcopp C, 2016, PEDIATR REV, V37, P193, DOI [10.1542/pir.2014-0095, 10.1159/000449268]
   Xiang D, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/5523516
   Zeitler P, 2012, NEW ENGL J MED, V366, P2247, DOI 10.1056/NEJMoa1109333
   Zeitler P, 2018, PEDIATR DIABETES, V19, P28, DOI 10.1111/pedi.12719
   Zimmermann E, 2017, OBESITY, V25, P965, DOI 10.1002/oby.21820
NR 113
TC 7
Z9 7
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9067
J9 CHILDREN-BASEL
JI Children-Basel
PD MAR
PY 2023
VL 10
IS 3
AR 516
DI 10.3390/children10030516
PG 20
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA C0TQ7
UT WOS:000959152000001
PM 36980074
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rezazadeh, K
   Aliashrafi, S
   Asghari-Jafarabadi, M
   Ebrahimi-Mameghani, M
AF Rezazadeh, Khatereh
   Aliashrafi, Soodabeh
   Asghari-Jafarabadi, Mohammad
   Ebrahimi-Mameghani, Mehrangiz
TI Antioxidant response to artichoke leaf extract supplementation in
   metabolic syndrome: A double-blind placebo-controlled randomized
   clinical trial
SO CLINICAL NUTRITION
LA English
DT Article
DE Artichoke leaf extract; Metabolic syndrome; Oxidative status; Oxidized
   low-density lipoprotein; Clinical trial
ID CYNARA-SCOLYMUS L.; LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS;
   PROTECTIVE PROPERTIES; PLASMA-CHOLESTEROL; IN-VITRO; DYSPEPSIA;
   ATHEROSCLEROSIS; HEALTH; LEAVES
AB Background: Oxidative stress is associated with most components and complications of Metabolic Syndrome (MetS). Artichoke Leaf Extract (ALE) has demonstrated anti-oxidant properties in both laboratory and animal studies. Aim: This study was designed to examine the effects of ALE on oxidative stress indices in patients with MetS.
   Methods: In the current double-blind placebo-controlled randomized clinical trial, 80 patients with MetS were randomly allocated to either "ALE group" (received 1800 mg ALE as four tablets per day) or "Placebo group" (received placebo containing cornstarch, lactose and avicel as four tablets per day) for 12 weeks. Serum levels of malondialdehyde (MDA), total antioxidant capacity (TAC), oxidized-LDL (ox-LDL), red blood cell glutathione peroxidase (GPx) and superoxidase dismutase (SOD), as well as dietary intakes were assessed at baseline and at the end of the study.
   Results: A total number of 68 patients completed the study (ALE group = 33; placebo group = 35). Dietary intakes of energy, macronutrients, and micronutrients were not significantly different between two groups throughout the trial, with the exception of zinc (p < 0.05). The concentration of ox-LDL decreased significantly in ALE group in comparison to the placebo group (-266.8 +/- 615.9 vs -129.5 +/- 591.2 ng/L; p < 0.05). However, no significant inter- and intra-group changes in MDA, SOD, GPx, and TAC concentrations were observed.
   Conclusion: ALE decreased serum ox-LDL level in patients with MetS, with no beneficial effects on other antioxidant indices.
   Clinical trial registration number: IRC1201409033320N9. (C) 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Rezazadeh, Khatereh] Tabriz Univ Med Sci, Sch Nutr & Food Sci, Talented Students Ctr, Student Res Comm, Tabriz, Iran.
   [Aliashrafi, Soodabeh] Tabriz Univ Med Sci, Sch Nutr & Food Sci, Student Res Comm, Tabriz, Iran.
   [Asghari-Jafarabadi, Mohammad] Tabriz Univ Med Sci, Rd Traff Injury Res Ctr, Tabriz, Iran.
   [Asghari-Jafarabadi, Mohammad] Tabriz Univ Med Sci, Sch Hlth, Dept Stat & Epidemiol, Tabriz, Iran.
   [Ebrahimi-Mameghani, Mehrangiz] Tabriz Univ Med Sci, Sch Nutr & Food Sci, Nutr Res Ctr, Attar Neyshaboori Av,Golghasht St, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Tabriz University of
   Medical Science; Tabriz University of Medical Science
RP Ebrahimi-Mameghani, M (corresponding author), Tabriz Univ Med Sci, Sch Nutr & Food Sci, Nutr Res Ctr, Attar Neyshaboori Av,Golghasht St, Tabriz, Iran.
EM ebrahimimamagani@tbzmed.ac.ir
RI Rezazadeh, Khatereh/N-2488-2019; Aliashrafi, Soodabeh/AAA-1337-2020;
   Asghari Jafarabadi, Mohammmad/A-7478-2017
OI Asghari Jafarabadi, Mohammmad/0000-0003-3284-9749; rezazadeh,
   khatereh/0000-0002-9270-7788
FU Tabriz University of Medical Sciences, Tabriz, Iran [5/97/4653]
FX The authors would like to thank the subjects who participated in this
   study and Dineh pharm. Co. for collaboration in preparation of Artichoke
   Leaf Extract and placebo tablets. Moreover, we kindly acknowledge Danesh
   Pathobiology Laboratory, Khoy, Iran for their assistance in biochemical
   assays. This study was supported by the Research Vice Chancellor, Tabriz
   University of Medical Sciences, Tabriz, Iran (grant number: 5/97/4653).
   The results of this article are derived from the Ph.D. thesis of
   khatereh Rezazadeh (NO, D/41).
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Ando K, 2009, FREE RADICAL BIO MED, V47, P213, DOI 10.1016/j.freeradbiomed.2009.04.030
   Azizi F, 2010, ARCH IRAN MED, V13, P426, DOI 010135/AIM.0011
   Brown JE, 1998, FREE RADICAL RES, V29, P247, DOI 10.1080/10715769800300281
   Bundy R, 2004, J ALTERN COMPLEM MED, V10, P667, DOI 10.1089/acm.2004.10.667
   Bundy R, 2008, PHYTOMEDICINE, V15, P668, DOI 10.1016/j.phymed.2008.03.001
   Demirbag R, 2006, INT J CLIN PRACT, V60, P1187, DOI 10.1111/j.1742-1241.2006.01042.x
   Demircan N, 2008, MED SCI MONITOR, V14, pCR97
   Englisch W, 2000, ARZNEIMITTELFORSCH, V50, pE260
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Gebhardt R, 1997, TOXICOL APPL PHARM, V144, P279, DOI 10.1006/taap.1997.8130
   Ghasemi Dehkordi A, 2002, IRANIAN HERBAL PHARM, V1-2
   Grassi D, 2010, NUTRIENTS, V2, P889, DOI 10.3390/nu2080889
   Grattagliano I, 2008, J NUTR BIOCHEM, V19, P491, DOI 10.1016/j.jnutbio.2007.06.011
   Holtmann G, 2003, ALIMENT PHARM THER, V18, P1099, DOI 10.1046/j.1365-2036.2003.01767.x
   Hopps E, 2010, NUTR METAB CARDIOVAS, V20, P72, DOI 10.1016/j.numecd.2009.06.002
   Jiménez-Escrig A, 2003, J AGR FOOD CHEM, V51, P5540, DOI 10.1021/jf030047e
   Küskü-Kiraz Z, 2010, PHYTOTHER RES, V24, P565, DOI 10.1002/ptr.2985
   LaGow B., 2004, PDR for Herbal Medicines, V3rd
   Llorach R, 2002, J AGR FOOD CHEM, V50, P3458, DOI 10.1021/jf0200570
   López-Uriarte P, 2010, CLIN NUTR, V29, P373, DOI 10.1016/j.clnu.2009.12.008
   Marakis G, 2002, PHYTOMEDICINE, V9, P694, DOI 10.1078/094471102321621287
   Mehmetçik G, 2008, EXP TOXICOL PATHOL, V60, P475, DOI 10.1016/j.etp.2008.04.014
   Mitra S, 2011, CARDIOVASC DRUG THER, V25, P419, DOI 10.1007/s10557-011-6341-5
   Moghaddam M.B., 2012, WORLD APPL SCI J, V18, P1073, DOI [DOI 10.5829/idosi.wasj.2012.18.08.754, 10.5829/idosi.wasj.2012.18.08]
   Panahi Y, 2015, CLIN NUTR, V34, P1101, DOI 10.1016/j.clnu.2014.12.019
   Pérez-García F, 2000, FREE RADICAL RES, V33, P661, DOI 10.1080/10715760000301171
   Procházková D, 2011, FITOTERAPIA, V82, P513, DOI 10.1016/j.fitote.2011.01.018
   Qiang ZY, 2012, PHYTOTHER RES, V26, P1048, DOI 10.1002/ptr.3698
   Rondanelli M, 2014, PHYTOTHER RES, V28, P33, DOI 10.1002/ptr.4950
   Shimoda H, 2003, BIOORG MED CHEM LETT, V13, P223, DOI 10.1016/S0960-894X(02)00889-2
   Steinberg D, 2010, ARTERIOSCL THROM VAS, V30, P2311, DOI 10.1161/ATVBAHA.108.179697
   Wang MF, 2003, J AGR FOOD CHEM, V51, P601, DOI 10.1021/jf020792b
   Zan MA, 2013, J FOOD SCI, V78, pT367, DOI 10.1111/1750-3841.12034
   Zapolska-Downar D, 2002, LIFE SCI, V71, P2897, DOI 10.1016/S0024-3205(02)02136-7
NR 35
TC 19
Z9 20
U1 0
U2 11
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD JUN
PY 2018
VL 37
IS 3
BP 790
EP 796
DI 10.1016/j.clnu.2017.03.017
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GG7LN
UT WOS:000432879800004
PM 28410922
DA 2025-06-11
ER

PT J
AU Ayers, K
   Byrne, LM
   DeMatteo, A
   Brown, NJ
AF Ayers, Katie
   Byrne, Loretta M.
   DeMatteo, Anthony
   Brown, Nancy J.
TI Differential Effects of Nebivolol and Metoprolol on Insulin Sensitivity
   and Plasminogen Activator Inhibitor in the Metabolic Syndrome
SO HYPERTENSION
LA English
DT Article
DE clinical science; insulin resistance; hypertension; cardiovascular
   pathophysiology; antihypertensive therapy
ID 3RD-GENERATION BETA-BLOCKER; TYPE-2 DIABETES-MELLITUS; OXIDATIVE STRESS;
   ENDOTHELIAL FUNCTION; FOREARM VASCULATURE; CARVEDILOL; HYPERTENSION;
   MORTALITY; ATENOLOL; EXPRESSION
AB Early-generation beta-blockers lower blood pressure and reduce cardiovascular morality in coronary artery disease and congestive heart failure but worsen glucose homeostasis and fibrinolytic balance. Nebivolol is a third-generation beta-blocker that increases the bioavailability of nitric oxide. We compared the effect of nebivolol (5 mg/d) and the beta(1)-selective antagonist metoprolol (100 mg/d) on glucose homeostasis and markers of fibrinolysis in 46 subjects with metabolic syndrome. Subjects underwent a frequently sampled IV glucose tolerance test after 3-week washout and placebo treatment and after randomized treatment with study drug. After 12-week treatment, nebivolol and metoprolol equivalently decreased systolic blood pressure, diastolic blood pressure, and heart rate. Neither drug affected beta-cell function, disposition index, or acute insulin response to glucose. Metoprolol significantly decreased the insulin sensitivity index. In contrast, nebivolol did not affect insulin sensitivity, and the decrease in sensitivity was significantly greater after metoprolol than after nebivolol (-1.5 +/- 2.5x10(-4) x min(-1) per milliunit per liter versus 0.04 +/- 2.19x10(-4) x min(-1) per milliunit per liter after nebivolol; P=0.03). Circulating plasminogen activator inhibitor also increased after treatment with metoprolol (from 9.8 +/- 6.8 to 12.3 +/- 7.8 ng/mL) but not nebivolol (from 10.8 +/- 7.8 to 10.5 +/- 6.2 ng/mL; P=0.05 versus metoprolol). Metoprolol, but not nebivolol, increased F-2-isoprostane concentrations. In summary, treatment with metoprolol decreased insulin sensitivity and increased oxidative stress and the antifibrinolytic plasminogen activator inhibitor 1 in patients with metabolic syndrome, whereas nebivolol lacked detrimental metabolic effects. Large clinical trials are needed to compare effects of nebivolol and the beta(1) receptor antagonist metoprolol on clinical outcomes in patients with hypertension and the metabolic syndrome. (Hypertension. 2012;59:893-898.)
C1 [Ayers, Katie; Byrne, Loretta M.; DeMatteo, Anthony; Brown, Nancy J.] Vanderbilt Univ, Sch Med, Dept Med, Div Clin Pharmacol, Nashville, TN 37232 USA.
C3 Vanderbilt University
RP Brown, NJ (corresponding author), Vanderbilt Univ, Sch Med, Dept Med, Div Clin Pharmacol, D-3100 Med Ctr North, Nashville, TN 37232 USA.
EM Nancy.j.brown@vanderbilt.edu
RI ayers, katie/A-6419-2013; Byrne, Loretta/JGE-0737-2023; Stefanadis,
   Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454
FU Forest Laboratories, Inc; National Institutes of Health [HL060906,
   UL1RR024975, T35007383]; Shire HRT
FX This work was funded through a grant from Forest Laboratories, Inc, as
   well as from funding from National Institutes of Health grants HL060906,
   UL1RR024975, and T35007383.N.J.B. consults for Novartis, Merck, and
   Boerhinger-Ingelheim; received research funding from Forest
   Laboratories, Inc; and receives research funding from Shire HRT.
CR Bakris GL, 2004, JAMA-J AM MED ASSOC, V292, P2227, DOI 10.1001/jama.292.18.2227
   Bank AJ, 2007, AM J HYPERTENS, V20, P777, DOI 10.1016/j.amjhyper.2007.01.019
   BERGMAN RN, 1985, ENDOCR REV, V6, P45, DOI 10.1210/edrv-6-1-45
   Boman K, 2010, CLIN APPL THROMB-HEM, V16, P146, DOI 10.1177/1076029609349501
   Bosch J, 2006, NEW ENGL J MED, V355, P1551
   Bouchie JL, 1998, ARTERIOSCL THROM VAS, V18, P1771, DOI 10.1161/01.ATV.18.11.1771
   Broeders MAW, 2000, CIRCULATION, V102, P677, DOI 10.1161/01.CIR.102.6.677
   Brown NJ, 1998, HYPERTENSION, V32, P965, DOI 10.1161/01.HYP.32.6.965
   Brown NJ, 2002, HYPERTENSION, V40, P859, DOI 10.1161/01.HYP.0000040264.15961.48
   Celik T, 2006, J HYPERTENS, V24, P591, DOI 10.1097/01.hjh.0000209993.26057.de
   Chen YQ, 1998, J BIOL CHEM, V273, P8225, DOI 10.1074/jbc.273.14.8225
   COCKCROFT JR, 1995, J PHARMACOL EXP THER, V274, P1067
   Dawes M, 1999, BRIT J CLIN PHARMACO, V48, P460
   Fahlbusch SA, 2004, EUR J CLIN PHARMACOL, V60, P83, DOI 10.1007/s00228-004-0729-0
   Flammer AJ, 2007, J HYPERTENS, V25, P785, DOI 10.1097/HJH.0b013e3280287a72
   Fonseca V, 2011, CURR MED RES OPIN, V27, P799, DOI 10.1185/03007995.2011.555477
   Fratta Pasini A, 2005, J HYPERTENS, V23, P589
   Grant PJ, 2007, J INTERN MED, V262, P157, DOI 10.1111/j.1365-2796.2007.01824.x
   Gudbjornsdottir S, 1997, EUR J CLIN INVEST, V27, P29, DOI 10.1046/j.1365-2362.1997.670617.x
   HJALMARSON A, 1981, LANCET, V2, P823
   Hjalmarson Å, 2000, BASIC RES CARDIOL, V95, P98
   Ingelsson E, 2007, CIRCULATION, V116, P984, DOI 10.1161/CIRCULATIONAHA.107.708537
   Jacob S, 1996, J HYPERTENS, V14, P489
   Jacob S, 2004, EXP CLIN ENDOCR DIAB, V112, P315, DOI 10.1055/s-2004-820915
   Kadiiska MB, 2005, FREE RADICAL BIO MED, V38, P698, DOI 10.1016/j.freeradbiomed.2004.09.017
   Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213
   Koyama Y, 2002, AM J HYPERTENS, V15, P927, DOI 10.1016/S0895-7061(02)03019-4
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lindholm LH, 2005, LANCET, V366, P1545, DOI 10.1016/S0140-6736(05)67573-3
   McMurray JJ, 2010, NEW ENGL J MED, V362, P1477, DOI 10.1056/NEJMoa1001121
   Morrow JD, 2005, ARTERIOSCL THROM VAS, V25, P279, DOI 10.1161/01.ATV.0000152605.64964.c0
   MORROW JD, 1990, P NATL ACAD SCI USA, V87, P9383, DOI 10.1073/pnas.87.23.9383
   Poirier L, 2001, J HYPERTENS, V19, P1429, DOI 10.1097/00004872-200108000-00011
   Sawathiparnich P, 2002, J CLIN ENDOCR METAB, V87, P448, DOI 10.1210/jc.87.2.448
   Scheen AJ, 2004, DRUGS, V64, P2537, DOI 10.2165/00003495-200464220-00004
   Schneider DJ, 1996, CORONARY ARTERY DIS, V7, P813, DOI 10.1097/00019501-199611000-00004
   Tarighi B, 2007, CAN J CARDIOL, V23, P651, DOI 10.1016/S0828-282X(07)70227-1
   Troost R, 2000, BRIT J CLIN PHARMACO, V50, P377, DOI 10.1046/j.1365-2125.2000.00258.x
   Vyssoulis GP, 2004, AM J HYPERTENS, V17, P582, DOI 10.1016/j.amjhyper.2004.03.668
   Wang YC, 2011, LANCET, V378, P815, DOI 10.1016/S0140-6736(11)60814-3
   Yilmaz MB, 2008, ADV THER, V25, P871, DOI 10.1007/s12325-008-0087-x
NR 41
TC 58
Z9 62
U1 0
U2 21
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD APR
PY 2012
VL 59
IS 4
BP 893
EP 898
DI 10.1161/HYPERTENSIONAHA.111.189589
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 911KQ
UT WOS:000301716100033
PM 22353614
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Gavia-García, G
   Hernández-Alvarez, D
   Arista-Ugalde, TL
   Aguiñiga-Sánchez, I
   Santiago-Osorio, E
   Mendoza-Núñez, VM
   Rosado-Pérez, J
AF Gavia-Garcia, Graciela
   Hernandez-Alvarez, David
   Arista-Ugalde, Taide Laurita
   Aguiniga-Sanchez, Itzen
   Santiago-Osorio, Edelmiro
   Mendoza-Nunez, Victor Manuel
   Rosado-Perez, Juana
TI The Supplementation of Sechium edule var. nigrum spinosum
   (Chayote) Promotes Nrf2-Mediated Antioxidant Protection in Older Adults
   with Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE Sechium edule; metabolic syndrome; antioxidants; inflammatory markers;
   aging; mRNA
ID NF-KAPPA-B; OXIDATIVE STRESS; NEURODEGENERATIVE DISEASES; CHLOROGENIC
   ACID; IN-VITRO; NRF2; ACTIVATION; EXPRESSION; PATHWAY; INFLAMMATION
AB The aim was to determine the effect of Sechium edule var. nigrum spinosum (chayote) on gene expression related to antioxidant protection mechanisms and the inflammatory process in older adults with metabolic syndrome (MetS). A quasi-experimental study was carried out in a convenience sample of 46 older adults diagnosed with MetS: (i) placebo group (PG; n = 20); (ii) experimental group (EG; n = 26). The clinical, biochemical, anthropometric parameters and SOD, GPx, and CAT enzyme activity, alongside total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), cytokines (IL-6, IL-8 and TNF-alpha), and mRNA expression of SOD, GPx, CAT, IL-6, IL-8, TNF-alpha, Nrf2, NFkB p50, and NFkB p65, were measured at baseline and 6 months post-intervention. A statistically significant decrease was observed in TOS (baseline, 28.9 +/- 3.6 vs. post, 23.7 +/- 3.4, p < 0.01) and OSI (baseline, 24.1 +/- 3.8 vs. post, 17.7 +/- 4), as well as an increase in IL-6 (baseline, 10.7 +/- 1.1 vs. post, 12.3 +/- 2, p = 0.03), SOD activity (baseline, 167.1 +/- 11.9 vs. post, 180.6 +/- 7.6, p < 0.05), CAT activity (baseline, 1.0 +/- 0.2 vs. post, 1.3 +/- 0.2, p < 0.01), and TAS (baseline, 1.1 +/- 0.1 vs. post, 1.4 +/- 0.1, p < 0.01) in the EG compared to the PG. Regarding the expression of Nrf2, SOD, and IL-6, the EG showed a significant increase vs. basal levels (47%, 44%, and 43%, respectively). Our findings suggest that Sechium edule supplementation promotes the antioxidant response and decreases oxidative stress via Nrf2.
C1 [Gavia-Garcia, Graciela; Hernandez-Alvarez, David; Arista-Ugalde, Taide Laurita; Mendoza-Nunez, Victor Manuel; Rosado-Perez, Juana] Univ Nacl Autonoma Mexico, FES Zaragoza, Res Unit Gerontol, Mexico City 09230, Mexico.
   [Aguiniga-Sanchez, Itzen; Santiago-Osorio, Edelmiro] Univ Nacl Autonoma Mexico, FES Zaragoza, Hematopoiesis & Leukemia Lab, Res Unit Cell Differentiat & Canc, Mexico City 09230, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma
   de Mexico
RP Mendoza-Núñez, VM; Rosado-Pérez, J (corresponding author), Univ Nacl Autonoma Mexico, FES Zaragoza, Res Unit Gerontol, Mexico City 09230, Mexico.
EM graciela_gavia_garcia@comunidad.unam.mx; hereda2912@gmail.com;
   tdlarista@comunidad.unam.mx; itzen.aguiniga@zaragoza.unam.mx;
   edelmiro@unam.mx; mendovic@unam.mx; juanarosadoperez@comunidad.unam.mx
RI Mendoza-Núñez, Víctor Manuel/AFL-2465-2022
OI Mendoza-Nunez, Victor Manuel/0000-0002-9137-3405; Santiago-Osorio,
   Edelmiro/0000-0002-4876-0688
FU National Council of Humanities, Science and Technology (CONAHCyT)
FX We appreciate the support from National Council of Humanities, Science
   and Technology (CONAHCyT) for the scholarship granted to Graciela
   Gavia-Garcia for her postdoctoral position.
CR Abdul-Muneer PM, 2023, J INTEGR NEUROSCI, V22, DOI 10.31083/j.jin2204081
   Adair TH MJ., 2010, Angiogenesis
   AEBI H, 1984, METHOD ENZYMOL, V105, P121
   Agbabiaka TB, 2017, DRUG AGING, V34, P891, DOI 10.1007/s40266-017-0501-7
   [Anonymous], Primer-BLAST-NCBI-NIH (Primer-BLAST)
   Avendano A.C.H., 2010, Las Variedades del Chayote Mexicano, Recurso Ancestral con Ppotencial de Comercializacion
   Bao LP, 2018, INT IMMUNOPHARMACOL, V54, P245, DOI 10.1016/j.intimp.2017.11.021
   Granado-Serrano AB, 2012, CHEM-BIOL INTERACT, V195, P154, DOI 10.1016/j.cbi.2011.12.005
   Cadena-Iñiguez J, 2008, GENET RESOUR CROP EV, V55, P835, DOI 10.1007/s10722-007-9288-4
   Caterson ID, 2004, CIRCULATION, V110, pE476, DOI 10.1161/01.CIR.0000140114.83145.59
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Boleti APD, 2021, NEURAL REGEN RES, V16, P688, DOI 10.4103/1673-5374.295329
   Dreger H, 2009, CARDIOVASC RES, V83, P354, DOI 10.1093/cvr/cvp107
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Fernández-Garcia JC, 2013, CURR VASC PHARMACOL, V11, P906, DOI 10.2174/15701611113116660175
   Gavia-García G, 2023, REDOX REP, V28, DOI 10.1080/13510002.2023.2207323
   Gavia-García G, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9070634
   Ghareghomi S, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10102668
   Gouveia ÉR, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18031303
   Ighodaro OM, 2018, ALEX J MED, V54, P287, DOI 10.1016/j.ajme.2017.09.001
   Jaiswal AK, 2004, FREE RADICAL BIO MED, V36, P1199, DOI 10.1016/j.freeradbiomed.2004.02.074
   Ji LL, 2002, ANN NY ACAD SCI, V959, P82, DOI 10.1111/j.1749-6632.2002.tb02085.x
   Kim Min-Jin, 2019, Korean Society for Biotechnology and Bioengineering Journal, V34, P99, DOI 10.7841/ksbbj.2019.34.2.99
   Kosmas CE, 2023, DIAGNOSTICS, V13, DOI 10.3390/diagnostics13050929
   Krzeminska J, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11010172
   Lampiasi N, 2018, IMMUNOBIOLOGY, V223, P349, DOI 10.1016/j.imbio.2017.10.046
   Arista-Ugalde TL, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11061076
   Lee Y, 2010, EUR J PHARMACOL, V643, P21, DOI 10.1016/j.ejphar.2010.06.016
   Li J, 2023, FOODS, V12, DOI 10.3390/foods12112120
   Liao HH, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/8370593
   Lim J, 2011, BIOL REPROD, V84, P775, DOI 10.1095/biolreprod.110.088583
   Lin YF, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/4517091
   Lin YJ, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.1074911
   Liu YJ, 2021, FOOD FUNCT, V12, P2148, DOI [10.1039/d0fo02707c, 10.1039/D0FO02707C]
   Liu ZY, 2022, FRONT BIOSCI-LANDMRK, V27, DOI 10.31083/j.fbl2702071
   Lombardo-Earl G, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/594326
   Ma CJ, 2022, EUR J PHARMACOL, V918, DOI 10.1016/j.ejphar.2021.174563
   Mendoza-Núñez VM, 2016, INT J GERONTOL, V10, P56, DOI 10.1016/j.ijge.2015.06.004
   Marasco MR, 2018, DIABETES, V67, P1576, DOI 10.2337/db17-1280
   Márquez-Sandoval F, 2011, PUBLIC HEALTH NUTR, V14, P1702, DOI 10.1017/S1368980010003320
   Matsumori A, 2023, EUR CARDIOL REV, V18, DOI 10.15420/ecr.2023.10
   Matsuoka Y, 2016, BRIT J CANCER, V115, P1234, DOI 10.1038/bjc.2016.327
   Millar CL, 2017, ADV NUTR, V8, P226, DOI 10.3945/an.116.014050
   Mohamed GA, 2022, J ETHNOPHARMACOL, V292, DOI 10.1016/j.jep.2022.115223
   Motamedi S, 2017, METAB BRAIN DIS, V32, P651, DOI 10.1007/s11011-017-9997-0
   OhIshi S, 1995, MECH AGEING DEV, V84, P65, DOI 10.1016/0047-6374(95)01637-F
   Ordoñez AAL, 2006, FOOD CHEM, V97, P452, DOI 10.1016/j.foodchem.2005.05.024
   Paredes-Gonzalez X, 2014, AAPS J, V16, P727, DOI 10.1208/s12248-014-9613-8
   Park SY, 2015, NEUROSCI LETT, V609, P129, DOI 10.1016/j.neulet.2015.10.022
   Patel S, 2009, PHARMACOL REP, V61, P595, DOI 10.1016/S1734-1140(09)70111-2
   Pruchniak MP, 2016, ADV EXP MED BIOL, V878, P9, DOI 10.1007/5584_2015_161
   Qin S, 2013, MOL NUTR FOOD RES, V57, P435, DOI 10.1002/mnfr.201200563
   Ranjan A, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20204981
   RAO G, 1990, J NUTR, V120, P602, DOI 10.1093/jn/120.6.602
   Rosado-Pérez J, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8050146
   Secretaria de Salud, 2002, Toma de Medidas Clinicas y Antropometricas en el Adulto Mayor
   Secretaria de Salud, 1999, Para la Prevencion, Tratamiento y Control de la Hipertension Arterial
   Sharma P, 2005, INDIAN J CLIN BIOCHE, V20, P145, DOI 10.1007/BF02893061
   Shen CY, 2023, TRANSL PSYCHIAT, V13, DOI 10.1038/s41398-023-02515-1
   Shen YB, 2019, BIOMED PHARMACOTHER, V111, P579, DOI 10.1016/j.biopha.2018.12.074
   Shi AM, 2018, INT IMMUNOPHARMACOL, V54, P125, DOI 10.1016/j.intimp.2017.11.007
   Soares Raquel, 2009, P85, DOI 10.1007/978-1-4020-9701-0_5
   Sohrabi F, 2021, ENVIRON SCI POLLUT R, V28, P56822, DOI 10.1007/s11356-021-14513-1
   Tossetta G, 2023, FRONT BIOSCI-LANDMRK, V28, DOI 10.31083/j.fbl2807143
   Tossetta G, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11040663
   Varì R, 2011, J NUTR BIOCHEM, V22, P409, DOI 10.1016/j.jnutbio.2010.03.008
   Vona R, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8267234
   Wang KH, 2017, INT J MOL MED, V40, P1582, DOI 10.3892/ijmm.2017.3134
   Wang X, 2023, NAT PROD RES, V37, P798, DOI 10.1080/14786419.2022.2089138
   Weng CJ, 2011, NEW BIOTECHNOL, V28, P767, DOI 10.1016/j.nbt.2011.05.003
   World Health Organization (WHO), 2022, Journal of Ageing and Economics
   Wruck CJ, 2011, J BIOL CHEM, V286, P4493, DOI 10.1074/jbc.M110.162008
   Wu CH, 2014, J AGR FOOD CHEM, V62, P750, DOI 10.1021/jf404611a
   Wu YY, 2023, CELL BIOL INT, V47, P598, DOI 10.1002/cbin.11960
   Yang SH, 2015, SCI REP-UK, V5, DOI 10.1038/srep15703
   Yeh CT, 2006, CARCINOGENESIS, V27, P1008, DOI 10.1093/carcin/bgi281
NR 76
TC 0
Z9 0
U1 4
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2023
VL 15
IS 19
AR 4106
DI 10.3390/nu15194106
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AZ9G5
UT WOS:001122378900001
PM 37836390
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Kuate, D
   Kengne, APN
   Biapa, CPN
   Azantsa, BGK
   Muda, WAMB
AF Kuate, Dieudonne
   Kengne, Anne Pascale Nouemsi
   Biapa, Cabral Prosper Nya
   Azantsa, Boris Gabin Kingue
   Muda, Wan Abdul Manan Bin Wan
TI Tetrapleura tetraptera spice attenuates high-carbohydrate,
   high-fat diet-induced obese and type 2 diabetic rats with metabolic
   syndrome features
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Obesity; Type 2 diabetes; High-carbohydrate high-fat diet; Metabolic
   syndrome; Inflammation; Tetrapleura tetraptera
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; DICHROSTACHYS-GLOMERATA;
   LIPID-METABOLISM; AQUEOUS EXTRACT; DRY FRUIT; HYPERGLYCEMIA;
   INFLAMMATION; ACID; ISOLIQUIRITIGENIN
AB Background: Tetrapleura tetraptera, a seasoning and nutritive spice is also used in western African folk medicine in the management of wide variety of diseases including diabetes, inflammation and hypertension. Flavonoids and saponins are some abundant secondary metabolic constituents in the fruits of this plant. This study aimed at evaluating the potential therapeutic action of the polyphenol-rich hydroethanolic extract (HET) of this fruit in experimentally induced obese and type 2 diabetic rats (T2DM) with characteristic metabolic syndrome (MetS).
   Methods: MetS was induced in rats by high-carbohydrate, high-fat diet and administration of low-dose streptozotocin. Then different oral doses of HET (200 and 400 mg/kg) were administered to T2DM rats for 28 days. A standard antidiabetic drug, metformin (300 mg/kg), was used for comparison. The body weight, systolic blood pressure, oxidative stress and metabolic parameters were then assessed to evaluate the effect of HET on MetS.
   Results: HET reduced weight gain, fasting blood glucose and plasma insulin levels as well as homeostasis model assessment of insulin resistance (HOMA-IR) and alleviated obesity and T2DM associated oxidative stress and hypertension in rats. Moreover, a significantly hypolipidemic property and an attenuation of liver injury and tissue steatosis was observed after HET administration. HET further demonstrated its anti-inflammation effect via down regulation of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), C-reactive protein (CRP), leptin and an increase in adiponectin. The HET exhibited dose-dependent effects which were comparable to that of metformin.
   Conclusions: The present study thereby demonstrates the anti-insulin resistance, antilipidemic, anti-obesity, hypotensive and anti-inflammatory properties of HET; hence it has the potential to be further developed for the management of MetS such as obesity, T2DM and hypertension.
C1 [Kuate, Dieudonne; Muda, Wan Abdul Manan Bin Wan] Univ Sains Malaysia, Sch Hlth Sci, Program Nutr, Kubang Kerian 16150, Kelantan, Malaysia.
   [Kuate, Dieudonne; Kengne, Anne Pascale Nouemsi; Biapa, Cabral Prosper Nya] Univ Dschang, Fac Sci, Dept Biochem, Dschang, Cameroon.
   [Azantsa, Boris Gabin Kingue] Univ Buea, Fac Sci, Dept Biochem & Mol Biol, Buea, Cameroon.
C3 Universiti Sains Malaysia; Universite de Dschang
RP Kuate, D (corresponding author), Univ Sains Malaysia, Sch Hlth Sci, Program Nutr, Kubang Kerian 16150, Kelantan, Malaysia.
EM kuatedie@msu.edu
RI ; khader, yousef/AAE-9620-2019; Wan Muda, Wan A Manan/H-5475-2016
OI Kengne, Andre Pascal/0000-0002-5183-131X; khader,
   yousef/0000-0002-7830-6857; Wan Muda, Wan A Manan/0000-0003-4241-3869
FU Universiti Sains Malaysia, TWAS (The World Academy of Sciences);
   University of Dschang
FX we are grateful to Universiti Sains Malaysia, TWAS (The World Academy of
   Sciences) and the University of Dschang for supporting this work.
CR Adams GG, 2011, FOOD RES INT, V44, P862, DOI 10.1016/j.foodres.2011.03.016
   ADESINA S K, 1982, International Journal of Crude Drug Research, V20, P93
   Adewunmi C.O, 1993, NIG J PARASITOL, V14, P45
   Afridi I, 2003, J HYPERTENS, V21, P1983, DOI 10.1097/01.hjh.0000084751-37215.d2
   Ahima RS, 2008, J CLIN INVEST, V118, P2380, DOI 10.1172/JCI36284
   AIDA K, 1990, PLANTA MED, V56, P254, DOI 10.1055/s-2006-960950
   Akin-Idowu P. E., 2011, Journal of Herbs, Spices & Medicinal Plants, V17, P52, DOI 10.1080/10496475.2011.560087
   Ali MM, 2004, Z NATURFORSCH C, V59, P726
   Amissah F, 2007, GHANA PHARM J, V32, P30
   Athyros VG, 2010, CURR DRUG TARGETS, V11, P122, DOI 10.2174/138945010790030992
   Bansal P, 2012, EXP TOXICOL PATHOL, V64, P651, DOI 10.1016/j.etp.2010.12.009
   Banu GS, 2009, FOOD CHEM TOXICOL, V47, P2361, DOI 10.1016/j.fct.2009.06.027
   Bastard JP, 2006, EUR CYTOKINE NETW, V17, P4
   Basu S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057873
   Bertoni AG, 2004, DIABETES CARE, V27, P699, DOI 10.2337/diacare.27.3.699
   Bosma M, 2012, PROG LIPID RES, V51, P36, DOI 10.1016/j.plipres.2011.11.003
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Chen FF, 2013, J ETHNOPHARMACOL, V149, P729, DOI 10.1016/j.jep.2013.07.035
   Cheng ZJ, 1998, BBA-LIPID LIPID MET, V1392, P291, DOI 10.1016/S0005-2760(98)00043-5
   Connell B. S. O., 2001, DIABETES SPECTRUM, V14, P196
   Cvetkovic T, 2009, J DIABETES COMPLICAT, V23, P337, DOI 10.1016/j.jdiacomp.2008.01.005
   Devalaraja S, 2011, FOOD RES INT, V44, P1856, DOI 10.1016/j.foodres.2011.04.008
   ESSIEN EU, 1994, PLANT FOOD HUM NUTR, V45, P47, DOI 10.1007/BF01091228
   Fleischer T., 2006, J SCI TECHNOLOGY, V26, P47, DOI [DOI 10.4314/JUST.V26I1.32961, 10.4314/just.v26i1.32961]
   Hansen D, 2010, EUR J APPL PHYSIOL, V109, P397, DOI 10.1007/s00421-010-1362-5
   International Diabetes Federation (IDF), 2013, 2013 IDF DIAB ATL
   Jeszka-Skowron M, 2014, J FUNCT FOODS, V8, P9, DOI 10.1016/j.jff.2014.02.018
   Jobu K, 2013, FOOD RES INT, V54, P324, DOI 10.1016/j.foodres.2013.07.037
   Johnson RJ, 2013, DIABETES, V62, P3307, DOI 10.2337/db12-1814
   Khan HBH, 2013, INFLAMMOPHARMACOLOGY, V21, P37, DOI 10.1007/s10787-011-0109-1
   Kovacs P, 2005, BEST PRACT RES CL EN, V19, P625, DOI 10.1016/j.beem.2005.07.003
   Kuate D, 2013, FUNCT FOODS HEALTH D, V3, P416, DOI 10.31989/ffhd.v3i11.35
   Kuate D, 2011, FOOD RES INT, V44, P1197, DOI 10.1016/j.foodres.2010.09.037
   Kyriazi E, 2011, HORM METAB RES, V43, P537, DOI 10.1055/s-0031-1277227
   Malik VS, 2010, DIABETES CARE, V33, P2477, DOI 10.2337/dc10-1079
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   MBOFUNG CMF, 1994, J SCI FOOD AGR, V66, P213, DOI 10.1002/jsfa.2740660216
   Mishima Y, 2001, DIABETES RES CLIN PR, V52, P119, DOI 10.1016/S0168-8227(00)00247-3
   Ngassoum MB, 2001, EUR FOOD RES TECHNOL, V213, P18, DOI 10.1007/s002170100330
   Nguyen S, 2009, J PEDIATR-US, V154, P807, DOI 10.1016/j.jpeds.2009.01.015
   Ojewole JAO, 2004, J ETHNOPHARMACOL, V95, P177, DOI 10.1016/j.jep.2004.06.026
   OJEWOLE JAO, 1983, PLANTA MED, V49, P46, DOI 10.1055/s-2007-969809
   Okokon JE, 2007, J ETHNOPHARMACOL, V111, P537, DOI 10.1016/j.jep.2006.12.030
   Peng CH, 2011, J AGR FOOD CHEM, V59, P9901, DOI 10.1021/jf2022379
   Petersen KF, 2006, AM J MED, V119, p10S, DOI 10.1016/j.amjmed.2006.01.009
   Prangthip P, 2013, J FUNCT FOODS, V5, P195, DOI 10.1016/j.jff.2012.10.005
   Qatanani M, 2007, GENE DEV, V21, P1443, DOI 10.1101/gad.1550907
   REEVES PG, 1993, J NUTR, V123, P1939, DOI 10.1093/jn/123.11.1939
   Schaffer JE, 2003, CURR OPIN LIPIDOL, V14, P281, DOI 10.1097/00041433-200306000-00008
   Shapiro A, 2008, AM J PHYSIOL-REG I, V295, pR1370, DOI 10.1152/ajpregu.00195.2008
   Tilg H, 2008, MOL MED, V14, P222, DOI 10.2119/2007-00119.Tilg
   Wang Y, 2008, J NUTR, V138, P1866, DOI 10.1093/jn/138.10.1866
   Wilcox LJ, 2001, J LIPID RES, V42, P725
   Xiao HF, 2013, FOOD RES INT, V54, P345, DOI 10.1016/j.foodres.2013.07.033
   Yamabe N, 2010, J ETHNOPHARMACOL, V129, P299, DOI 10.1016/j.jep.2010.03.032
   YAMAMOTO S, 1991, CARCINOGENESIS, V12, P317, DOI 10.1093/carcin/12.2.317
   Yang YS, 2013, J FUNCT FOODS, V5, P810, DOI 10.1016/j.jff.2013.01.027
   YU SM, 1995, BRIT J PHARMACOL, V114, P1587, DOI 10.1111/j.1476-5381.1995.tb14943.x
   Zheng T, 2012, J ETHNOPHARMACOL, V139, P814, DOI 10.1016/j.jep.2011.12.025
   Zimmet P, 2001, NATURE, V414, P782, DOI 10.1038/414782a
NR 60
TC 65
Z9 66
U1 0
U2 23
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD MAY 24
PY 2015
VL 14
AR 50
DI 10.1186/s12944-015-0051-0
PG 13
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA CJ0PO
UT WOS:000355179300001
PM 26003803
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kahl, KG
   Schweiger, U
   Pars, K
   Kunikowska, A
   Deuschle, M
   Gutberlet, M
   Lichtinghagen, R
   Bleich, S
   Hüper, K
   Hartung, D
AF Kahl, Kai G.
   Schweiger, Ulrich
   Pars, Kaweh
   Kunikowska, Alicja
   Deuschle, Michael
   Gutberlet, Marcel
   Lichtinghagen, Ralf
   Bleich, Stefan
   Hueper, Katja
   Hartung, Dagmar
TI Adrenal gland volume, intra-abdominal and pericardial adipose tissue in
   major depressive disorder
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Major depressive disorder; Adrenal gland volume; Ectopic fat
ID CORONARY-HEART-DISEASE; VISCERAL FAT; ATHEROSCLEROSIS MESA; INSULIN
   SENSITIVITY; PREMENOPAUSAL WOMEN; COMPUTED-TOMOGRAPHY; CARDIOVASCULAR
   RISK; METABOLIC SYNDROME; METAANALYSIS; ASSOCIATION
AB Major depressive disorder (MDD) is associated with an increased risk for the development of cardio-metabolic diseases. Increased intra-abdominal (IAT) and pericardial adipose tissue (PAT) have been found in depression, and are discussed as potential mediating factors. IAT and PAT are thought to be the result of a dysregulation of the hypothalamus pituitary adrenal axis (HPAA) with subsequent hypercortisolism. Therefore we examined adrenal gland volume as proxy marker for HPAA activation, and IAT and PAT in depressed patients. Twenty-seven depressed patients and 19 comparison subjects were included in this case-control study. Adrenal gland volume, pericardial, intraabdominal and subcutaneous adipose tissue were measured by magnetic resonance imaging. Further parameters included factors of the metabolic syndrome, fasting cortisol, fasting insulin, and proinflammatory cytokines. Adrenal gland and pericardial adipose tissue volumes, serum concentrations of cortisol and insulin, and serum concentrations tumor necrosis factor-a were increased in depressed patients. Adrenal gland volume was positively correlated with intra-abdominal and pericardial adipose tissue, but not with subcutaneous adipose tissue. Our findings point to the role of HPAA dysregulation and hypercortisolism as potential mediators of IAT and PAT enlargement. Further studies are warranted to examine whether certain subtypes of depression are more prone to cardio-metabolic diseases. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Kahl, Kai G.; Pars, Kaweh; Kunikowska, Alicja; Bleich, Stefan] Hannover Med Sch MHH, Dept Psychiat Social Psychiat & Psychotherapy, Hannover, Germany.
   [Gutberlet, Marcel; Hueper, Katja; Hartung, Dagmar] MHH, Inst Diagnost & Intervent Radiol, Hannover, Germany.
   [Lichtinghagen, Ralf] MHH, Inst Clin Chem, Hannover, Germany.
   [Schweiger, Ulrich] Univ Lubeck, Dept Psychiat & Psychotherapy, Lubeck, Germany.
   [Deuschle, Michael] Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, Mannheim, Germany.
C3 Hannover Medical School; Hannover Medical School; Hannover Medical
   School; University of Lubeck; Central Institute of Mental Health
RP Kahl, KG (corresponding author), Hannover Med Sch MHH, Dept Psychiat Social Psychiat & Psychotherapy, Hannover, Germany.
EM kahl.kai@mh-hannover.de
RI Hueper, Katja/J-9566-2016; Gutberlet, Matthias/AAL-2699-2021; Bleich,
   Stefan/ABC-1796-2020
CR Alexopoulos N, 2014, ATHEROSCLEROSIS, V233, P104, DOI 10.1016/j.atherosclerosis.2013.12.023
   AMSTERDAM JD, 1987, PSYCHIAT RES, V21, P189, DOI 10.1016/0165-1781(87)90022-9
   Cuppett M, 2002, J ATHL TRAINING, V37, P281
   Debono M, 2013, J CLIN ENDOCR METAB, V98, P2383, DOI 10.1210/jc.2012-4276
   Ding JZ, 2008, OBESITY, V16, P1914, DOI 10.1038/oby.2008.278
   Ding JZ, 2009, AM J CLIN NUTR, V90, P499, DOI 10.3945/ajcn.2008.27358
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Ermetici F, 2007, METABOLISM, V56, P686, DOI 10.1016/j.metabol.2006.12.018
   Eskandari F, 2005, METABOLISM, V54, P918, DOI 10.1016/j.metabol.2005.02.006
   Everson-Rose SA, 2009, PSYCHOSOM MED, V71, P410, DOI 10.1097/PSY.0b013e3181a20c9c
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Giordano R, 2012, ENDOCRINE, V41, P415, DOI 10.1007/s12020-012-9628-9
   Golden SH, 2007, J CLIN ENDOCR METAB, V92, P1358, DOI 10.1210/jc.2006-2674
   Greggersen W, 2011, EUR ARCH PSY CLIN N, V261, P551, DOI 10.1007/s00406-011-0194-6
   Iacobellis G, 2013, ENDOCRINE, V44, P532, DOI 10.1007/s12020-013-9902-5
   Imaki T, 2004, ENDOCR J, V51, P89, DOI 10.1507/endocrj.51.89
   Kahl KG, 2014, ACTA PSYCHIAT SCAND, V130, P137, DOI 10.1111/acps.12242
   Kahl KG, 2012, EUR ARCH PSY CLIN N, V262, P313, DOI 10.1007/s00406-011-0277-4
   Kahl KG, 2005, PSYCHOSOM MED, V67, P407, DOI 10.1097/01.psy.0000160458.95955.f4
   Kessing LV, 2011, PSYCHONEUROENDOCRINO, V36, P19, DOI 10.1016/j.psyneuen.2010.05.007
   Kim NH, 2011, J AM GERIATR SOC, V59, P2062, DOI 10.1111/j.1532-5415.2011.03664.x
   Kim TH, 2011, OBESITY, V19, P1028, DOI 10.1038/oby.2010.246
   Krishnamurthy P, 2008, HORM METAB RES, V40, P194, DOI 10.1055/s-2007-1004541
   Kuk JL, 2006, OBESITY, V14, P336, DOI 10.1038/oby.2006.43
   Ludescher B, 2008, INT J PSYCHIAT MED, V38, P229, DOI 10.2190/PM.38.3.a
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Miao CL, 2011, RADIOLOGY, V261, P109, DOI 10.1148/radiol.11110346
   Mitchell AJ, 2015, GEN HOSP PSYCHIAT, V37, P14, DOI 10.1016/j.genhosppsych.2014.11.006
   Murray CJL, 2012, LANCET, V380, P2197, DOI 10.1016/S0140-6736(12)61729-2
   NEMEROFF CB, 1992, ARCH GEN PSYCHIAT, V49, P384
   Nicklas BJ, 2004, AM J EPIDEMIOL, V160, P741, DOI 10.1093/aje/kwh281
   REBUFFESCRIVE M, 1990, J CLIN ENDOCR METAB, V71, P1215, DOI 10.1210/jcem-71-5-1215
   REBUFFESCRIVE M, 1992, PHYSIOL BEHAV, V52, P583, DOI 10.1016/0031-9384(92)90351-2
   Remer T, 2008, MINI-REV MED CHEM, V8, P153, DOI 10.2174/138955708783498096
   Rosmalen JGM, 2014, PSYCHONEUROENDOCRINO, V47, P10, DOI 10.1016/j.psyneuen.2014.04.018
   Rubin RT, 1996, BIOL PSYCHIAT, V40, P89, DOI 10.1016/0006-3223(95)00358-4
   Rugulies R, 2002, AM J PREV MED, V23, P51, DOI 10.1016/S0749-3797(02)00439-7
   Scharnholz B, 2014, PSYCHONEUROENDOCRINO, V39, P104, DOI 10.1016/j.psyneuen.2013.09.030
   Soliman EZ, 2010, J STROKE CEREBROVASC, V19, P58, DOI 10.1016/j.jstrokecerebrovasdis.2009.03.008
   Stetler C, 2011, PSYCHOSOM MED, V73, P114, DOI 10.1097/PSY.0b013e31820ad12b
   Surtees PG, 2008, AM J PSYCHIAT, V165, P515, DOI 10.1176/appi.ajp.2007.07061018
   Valkanova V, 2013, J AFFECT DISORDERS, V150, P736, DOI 10.1016/j.jad.2013.06.004
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Wajchenberg BL, 2000, ENDOCR REV, V21, P697, DOI 10.1210/er.21.6.697
   Weber-Hamann B, 2002, PSYCHOSOM MED, V64, P274, DOI 10.1097/00006842-200203000-00010
   Weber-Hamann B, 2006, J CLIN PSYCHIAT, V67, P1856, DOI 10.4088/JCP.v67n1204
   Williams LJ, 2009, J AFFECT DISORDERS, V118, P173, DOI 10.1016/j.jad.2009.02.001
NR 47
TC 27
Z9 29
U1 0
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD AUG
PY 2015
VL 58
BP 1
EP 8
DI 10.1016/j.psyneuen.2015.04.008
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA CL1XR
UT WOS:000356738700001
PM 25935636
DA 2025-06-11
ER

PT J
AU de Cordova, PB
   Bradford, MA
   Stone, PW
AF de Cordova, Pamela B.
   Bradford, Michelle A.
   Stone, Patricia W.
TI Increased errors and decreased performance at night: A systematic review
   of the evidence concerning shift work and quality
SO WORK-A JOURNAL OF PREVENTION ASSESSMENT & REHABILITATION
LA English
DT Review
DE After-hours; efficiency; productivity; safety
ID MENTAL-HEALTH STATUS; HOSPITAL NURSES; METABOLIC SYNDROME; SLEEP
   DISORDERS; MEDICAL ERRORS; PATIENT-CARE; INJURIES; ALERTNESS; OUTCOMES;
   FATIGUE
AB BACKGROUND: Shift workers have worse health outcomes than employees who work standard business hours. However, it is unclear how this poorer health shift may be related to employee work productivity.
   OBJECTIVE: The purpose of this systematic review is to assess the relationship between shift work and errors and performance.
   METHODS: Searches of MEDLINE/PubMed, EBSCOhost, and CINAHL were conducted to identify articles that examined the relationship between shift work, errors, quality, productivity, and performance. All articles were assessed for study quality.
   RESULTS: A total of 435 abstracts were screened with 13 meeting inclusion criteria. Eight studies were rated to be of strong, methodological quality. Nine studies demonstrated a positive relationship that night shift workers committed more errors and had decreased performance.
   CONCLUSIONS: Night shift workers have worse health that may contribute to errors and decreased performance in the workplace.
C1 [de Cordova, Pamela B.; Bradford, Michelle A.] Rutgers State Univ, Newark, NJ 07102 USA.
   [Stone, Patricia W.] Columbia Univ, Sch Nursing, Ctr Hlth Policy, New York, NY USA.
C3 Rutgers University System; Rutgers University Newark; Rutgers University
   New Brunswick; Columbia University
RP de Cordova, PB (corresponding author), Rutgers State Univ, Nursing, 180 Univ Ave,Room 244, Newark, NJ 07102 USA.
EM pam.decordova@rutgers.edu
RI de Cordova, Pamela/JXL-7188-2024
OI de Cordova, Pamela/0000-0003-4737-8652
CR Akerstedt T, 1998, Sleep Med Rev, V2, P117, DOI 10.1016/S1087-0792(98)90004-1
   Åkerstedt T, 2005, J SLEEP RES, V14, P17, DOI 10.1111/j.1365-2869.2004.00437.x
   Arakawa C, 2011, IND HEALTH, V49, P381, DOI 10.2486/indhealth.MS968
   Arimura M, 2010, IND HEALTH, V48, P811, DOI 10.2486/indhealth.MS1093
   Berger Ann M, 2006, Clin J Oncol Nurs, V10, P465, DOI 10.1188/06.CJON.465-471
   Biggi N, 2008, CHRONOBIOL INT, V25, P443, DOI 10.1080/07420520802114193
   Bonnefond A, 2001, ERGONOMICS, V44, P937, DOI 10.1080/00140130110061138
   Chang YS, 2011, SLEEP MED, V12, P866, DOI 10.1016/j.sleep.2011.03.018
   Chen JD, 2010, CHRONOBIOL INT, V27, P334, DOI 10.3109/07420520903502242
   Chen Shelley I, 2006, AAOHN J, V54, P262
   Cheng V, 2008, THESIS
   Costa G, 2004, CHRONOBIOL INT, V21, P831, DOI 10.1081/CBI-200035935
   de Cordova PB, 2012, J ADV NURS, V68, P1454, DOI 10.1111/j.1365-2648.2012.05976.x
   Demerouti E, 2004, ERGONOMICS, V47, P987, DOI 10.1080/00140130410001670408
   Dixon-Woods M, 2004, QUAL SAF HEALTH CARE, V13, P223, DOI 10.1136/qshc.2003.008714
   Downs SH, 1998, J EPIDEMIOL COMMUN H, V52, P377, DOI 10.1136/jech.52.6.377
   Estabrooks CA, 2009, QUAL SAF HEALTH CARE, V18, P181, DOI 10.1136/qshc.2007.024232
   Folkard S, 2004, AVIAT SPACE ENVIR MD, V75, pA161
   Folkard S, 2006, CHRONOBIOL INT, V23, P1181, DOI 10.1080/07420520601096443
   Garbarino S, 2002, SLEEP, V25, P648
   Gillberg M, 2003, INT J IND ERGONOM, V31, P101, DOI 10.1016/S0169-8141(02)00178-6
   Glance LG, 2012, BMC HEALTH SERV RES, V12, DOI 10.1186/1472-6963-12-247
   Härmä M, 2002, J SLEEP RES, V11, P141, DOI 10.1046/j.1365-2869.2002.00294.x
   Hendey GW, 2005, ACAD EMERG MED, V12, P629, DOI 10.1197/j.aem.2005.02.009
   Herman J, 2014, INJURY, V45, P586, DOI 10.1016/j.injury.2013.06.007
   Ingre M, 2006, J SLEEP RES, V15, P47, DOI 10.1111/j.1365-2869.2006.00504.x
   Jay SM, 2008, APPL ERGON, V39, P623, DOI 10.1016/j.apergo.2008.01.011
   Kahol K, 2008, AM J SURG, V195, P195, DOI 10.1016/j.amjsurg.2007.10.004
   Lee S, 2007, ROUTL STUD MOD WORLD, V71, P1
   Lieber RR, 2012, WORK, V41, P5847, DOI 10.3233/WOR-2012-0971-5847
   McMenamin T., 2007, Monthly Labor Review
   Mitchell DL, 2008, J AGRIC SAF HEALTH, V14, P391, DOI 10.13031/2013.25278
   Moher D, 2009, PHYS THER, V89, P873, DOI 10.1093/ptj/89.9.873
   Nicholls A, 2004, INT J FOREST ENG
   Niu SF, 2013, BIOL RES NURS, V15, P443, DOI 10.1177/1099800412445907
   Purnell MT, 2002, J SLEEP RES, V11, P219, DOI 10.1046/j.1365-2869.2002.00309.x
   Rajaratnam SMW, 2011, JAMA-J AM MED ASSOC, V306, P2567, DOI 10.1001/jama.2011.1851
   Sallinen M, 2003, J SLEEP RES, V12, P103, DOI 10.1046/j.1365-2869.2003.00346.x
   Shen J, 2008, INT J HUM RESOUR MAN, V19, P392, DOI 10.1080/09585190701799978
   Silbergleit R, 2006, ACAD EMERG MED, V13, P325, DOI 10.1197/j.aem.2005.09.005
   Smith-Coggins R, 2006, ANN EMERG MED, V48, P596, DOI 10.1016/j.annemergmed.2006.02.005
   Son M, 2008, J SLEEP RES, V17, P385, DOI 10.1111/j.1365-2869.2008.00675.x
   Sorita A, 2014, BMJ-BRIT MED J, V348, DOI 10.1136/bmj.f7393
   Stimpfel AW, 2013, J NURS CARE QUAL, V28, P122, DOI 10.1097/NCQ.0b013e3182725f09
   Stone PW, 2006, MED CARE, V44, P1099, DOI 10.1097/01.mlr.0000237180.72275.82
   Suzuki K, 2004, J OCCUP HEALTH, V46, P448, DOI 10.1539/joh.46.448
   Thompson DA, 2013, J NURSING CARE, V2, P1
   Trinkoff A, 2006, AM J NURS, V106, P60, DOI 10.1097/00000446-200604000-00030
   Violanti JM, 2009, ARCH ENVIRON OCCUP H, V64, P194, DOI 10.1080/19338240903241259
   Wilson Janet L, 2002, J Nurs Manag, V10, P211, DOI 10.1046/j.1365-2834.2002.00308.x
   Zhao I, 2010, AUST J ADV NURS, V27, P62
NR 51
TC 51
Z9 59
U1 0
U2 41
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1051-9815
EI 1875-9270
J9 WORK
JI Work
PY 2016
VL 53
IS 4
BP 825
EP 834
DI 10.3233/WOR-162250
PG 10
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA DM6PQ
UT WOS:000376475300013
PM 26890590
DA 2025-06-11
ER

PT J
AU Ari, H
   Kayrak, M
   Gündüz, M
   Kayhan, F
   Kaya, Z
   Kiyici, A
   Uguz, F
AF Ari, Hatem
   Kayrak, Mehmet
   Gunduz, Mehmet
   Kayhan, Fatih
   Kaya, Zeynettin
   Kiyici, Aysel
   Uguz, Faruk
TI Association of paraoxonase-1 activity and major depressive disorder in
   patients with metabolic syndrome
SO INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
LA English
DT Article
DE Metabolic syndrome; Depressive disorder; Paraoxonase-1 activity
ID CORONARY-ARTERY-DISEASE; HIGH-DENSITY-LIPOPROTEIN; HEART-DISEASE;
   OXIDATIVE STRESS; PON1; GENE; POLYMORPHISM; METAANALYSIS; WOMEN; RISK
AB Associations between metabolic syndrome (MS) and major depressive disorder (MDD) are well documented although the underlying biological mechanisms for this relationship are less studied. Paraoxonase (PON1) is a high-density lipoprotein (HDL)-associated enzyme, with demonstrated evidence of strong antioxidant activity. Oxidative stress has been implicated in the pathophysiology of MS and MDD. PON1 activity has been studied to some extent in patients with MS and less in MDD. The aim of this study was to compare serum PON1 activity in patients with MS and MDD, MS without MDD, and normal control groups in the context of the biological mechanism of the association between MS and MDD. In this case-control study, 67 patients with MS and 25 healthy controls from the hospital-university staff were recruited. All patients and healthy controls were assessed by a semi-structured psychiatric interview. Patients with MDD were diagnosed according to the DSM-IV criteria for MDD. Serum PON1 activity was determined with a spectrophotometric method, and the activity was compared between patients with MS and MDD, with MS but without MDD, and control groups. Serum PON1 activity levels were lower in patients with MS and MDD group compared to those in the patients with MS and without MDD group and control group (69.5+/-24.2, 84.3+/-34.6, and 97.1+/-40.8 U/ml, p=0.03, respectively). Post hoc analysis showed that PON1 activity was statically significantly lower in the MS with MDD group than in the control group (p=0.02). Impaired PON1 activity, in the context of enhanced oxidative stress, could be one of the possible underlying biological mechanisms of the MS-MDD association.
C1 [Ari, Hatem] Suleyman Demirel Univ, Sch Med, Dept Cardiol, TR-32200 Isparta, Turkey.
   [Kayrak, Mehmet; Gunduz, Mehmet; Kaya, Zeynettin] Selcuk Univ, Meram Sch Med, Dept Cardiol, Konya, Turkey.
   [Kayhan, Fatih; Uguz, Faruk] Selcuk Univ, Meram Sch Med, Dept Psychiat, Konya, Turkey.
   [Kiyici, Aysel] Selcuk Univ, Meram Sch Med, Dept Biochem, Konya, Turkey.
C3 Suleyman Demirel University; Selcuk University; Selcuk University;
   Selcuk University
RP Ari, H (corresponding author), Suleyman Demirel Univ, Sch Med, Dept Cardiol, TR-32200 Isparta, Turkey.
EM hatem_ari@hotmail.com; mehmetkayrak@yahoo.com; m_gunduz@yahoo.com;
   drkayhan@yahoo.com; zeynettinkaya@yahoo.com; ayselkiyici@gmail.com;
   farukuguz@hotmail.com
RI kaya, zeynettin/AAP-7705-2020
CR [Anonymous], 1999, Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications: Report of a WHO Consultation-Part 1: Diagnosis and Classification of Diabetes Mellitus
   [Anonymous], 2000, DIAGN STAT MAN MENT
   Cho KH, 2009, BMB REP, V42, P393, DOI 10.5483/BMBRep.2009.42.7.393
   ECKERSON HW, 1983, AM J HUM GENET, V35, P1126
   EVANS PH, 1993, BRIT MED BULL, V49, P577, DOI 10.1093/oxfordjournals.bmb.a072632
   Ferré N, 2003, CLIN CHEM, V49, P1491, DOI 10.1373/49.9.1491
   Gaidukov L, 2007, J LIPID RES, V48, P1637, DOI 10.1194/jlr.D600045-JLR200
   Garin MCB, 2005, J CLIN ENDOCR METAB, V90, P2264, DOI 10.1210/jc.2004-1295
   Goldston K, 2008, CLIN PSYCHOL REV, V28, P288, DOI 10.1016/j.cpr.2007.05.005
   Granér M, 2006, J AM COLL CARDIOL, V47, P2429, DOI 10.1016/j.jacc.2006.01.074
   Grundy SM, 2007, J CLIN ENDOCR METAB, V92, P399, DOI 10.1210/jc.2006-0513
   Gur M, 2006, EUR J CLIN INVEST, V36, P779, DOI 10.1111/j.1365-2362.2006.01727.x
   James RW, 2000, CIRCULATION, V101, P2252, DOI 10.1161/01.CIR.101.19.2252
   Kodydková J, 2009, CLIN BIOCHEM, V42, P1368, DOI 10.1016/j.clinbiochem.2009.06.006
   Lawlor DA, 2007, J EPIDEMIOL COMMUN H, V61, P85, DOI 10.1136/jech.2006.049247
   Leviev I, 2000, ARTERIOSCL THROM VAS, V20, P516, DOI 10.1161/01.ATV.20.2.516
   LI WF, 1993, J TOXICOL ENV HEALTH, V40, P337, DOI 10.1080/15287399309531798
   Mackness B, 2001, ARTERIOSCL THROM VAS, V21, P1451, DOI 10.1161/hq0901.094247
   Mackness MI, 1996, CURR OPIN LIPIDOL, V7, P69, DOI 10.1097/00041433-199604000-00004
   MACKNESS MI, 1993, ATHEROSCLEROSIS, V104, P129, DOI 10.1016/0021-9150(93)90183-U
   Marazziti D, 2014, CNS SPECTRUMS, V19, P293, DOI 10.1017/S1092852913000667
   Martinelli N, 2012, EXP DIABETES RES, DOI 10.1155/2012/231502
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Paz G, 2010, REV BRAS PSIQUIATR, V32, P181, DOI 10.1590/S1516-44462010000200015
   PrimoParmo SL, 1996, GENOMICS, V33, P498, DOI 10.1006/geno.1996.0225
   Sanghera DK, 1997, ARTERIOSCL THROM VAS, V17, P1067, DOI 10.1161/01.ATV.17.6.1067
   Sarandol A, 2006, PROG NEURO-PSYCHOPH, V30, P1103, DOI 10.1016/j.pnpbp.2006.04.012
   Sentí M, 2003, J CLIN ENDOCR METAB, V88, P5422, DOI 10.1210/jc.2003-030648
   Seres I, 2004, EXP GERONTOL, V39, P59, DOI 10.1016/j.exger.2003.08.001
   She ZG, 2012, ANTIOXID REDOX SIGN, V16, P597, DOI 10.1089/ars.2010.3774
   Wagner G, 2014, DEUT MED WOCHENSCHR, V139, P369, DOI 10.1055/s-0033-1360066
   Watson AD, 1995, J CLIN INVEST, V96, P2882, DOI 10.1172/JCI118359
   Whaley-Connell A, 2011, REV CARDIOVASC MED, V12, P21, DOI 10.3909/ricm0555
   Wheeler JG, 2004, LANCET, V363, P689, DOI 10.1016/S0140-6736(04)15642-0
   Wolkowitz Owen M, 2011, Dialogues Clin Neurosci, V13, P25
   Zhou CY, 2013, DIS MARKERS, V2013, P97, DOI 10.1155/2013/816189
NR 36
TC 1
Z9 1
U1 0
U2 7
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0973-3930
EI 1998-3832
J9 INT J DIABETES DEV C
JI Int. Diabetes Dev. Ctries.
PD SEP
PY 2015
VL 35
SU 2
BP S258
EP S263
DI 10.1007/s13410-015-0385-1
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CY6OP
UT WOS:000366529000029
DA 2025-06-11
ER

PT J
AU Pfeuffer, M
   Fielitz, K
   Laue, C
   Winkler, P
   Rubin, D
   Helwig, U
   Giller, K
   Kammann, J
   Schwedhelm, E
   Böger, RH
   Bub, A
   Bell, D
   Schrezenmeir, J
AF Pfeuffer, Maria
   Fielitz, Kerstin
   Laue, Christiane
   Winkler, Petra
   Rubin, Diana
   Helwig, Ulf
   Giller, Katrin
   Kammann, Julia
   Schwedhelm, Edzard
   Boeger, Rainer H.
   Bub, Achim
   Bell, Doris
   Schrezenmeir, Juergen
TI CLA Does Not Impair Endothelial Function and Decreases Body Weight as
   Compared with Safflower Oil in Overweight and Obese Male Subjects
SO JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
LA English
DT Article
DE endothelial function; metabolic syndrome; cardiovascular disease; PAT
   index
ID CONJUGATED LINOLEIC-ACID; LOW-DENSITY-LIPOPROTEIN; ACTIVATING-FACTOR
   ACETYLHYDROLASE; TANDEM MASS-SPECTROMETRY; C-REACTIVE PROTEIN; VIRGIN
   OLIVE OIL; OXIDATIVE STRESS; LIPID-PEROXIDATION; METABOLIC SYNDROME; FAT
   MASS
AB Objective: Conjugated linoleic acid (CLA) showed a wide range of beneficial biological effects with relevance for cardiovascular health in animal models and humans. Most human studies used olive oil as a reference. This study assessed the effect of CLA as compared with safflower oil on endothelial function and markers of cardiovascular risk in overweight and obese men. Heated safflower oil and olive oil were given for additional descriptive control.
   Methods: Eighty-five overweight men (aged 45-68 years, body mass index 25-35 kg/m(2)) were randomized to receive 4.5 g/d of the CLA isomeric mixture, safflower oil, heated safflower oil, or olive oil in a 4-week double-blind study. Endothelial function was assessed by peripheral arterial tonometry (PAT) index determination in the fasting and postprandial state (i.e., 4 hours after consumption of a fat- and sucrose-rich meal).
   Results: CLA as compared with safflower oil consumption did not impair fasting or postprandial PAT index but decreased body weight. CLA as compared with safflower oil did not change total, low-density lipoprotein (LDL), or high-density lipoprotein (HDL) cholesterol; triglycerides; insulin sensitivity indices; C-reactive protein; soluble adhesion molecules; oxidized LDL; lipoprotein a (Lp[a]); paraoxonase; or platelet-activating factor acetylhydrolase (PAF-AH) activity, but significantly reduced arylesterase activity and increased concentrations of the F-2-isoprostane 8-iso-prostaglandin F (PGF)(2 alpha).
   Conclusion: CLA did not impair endothelial function. Other parameters associated with metabolic syndrome and oxidative stress were not changed or were slightly improved. Results suggest that CLA does not increase cardiovascular risk. Increased F2-isoprostane concentrations in this context may not indicate increased oxidative stress.
C1 [Pfeuffer, Maria; Fielitz, Kerstin; Rubin, Diana; Helwig, Ulf; Giller, Katrin; Kammann, Julia; Bub, Achim; Schrezenmeir, Juergen] Max Rubner Inst, Dept Physiol & Biochem Nutr, D-76131 Karlsruhe, Germany.
   [Pfeuffer, Maria; Fielitz, Kerstin; Rubin, Diana; Helwig, Ulf; Giller, Katrin; Kammann, Julia; Bub, Achim; Schrezenmeir, Juergen] Max Rubner Inst, Dept Physiol & Biochem Nutr, Kiel, Germany.
   [Fielitz, Kerstin; Laue, Christiane; Winkler, Petra] Tecura GmbH, Clin Res Ctr, Kiel, Germany.
   [Rubin, Diana] Univ Clin Schleswig Holstein, Dept Gen Internal Med, Campus Kiel, Germany.
   [Schwedhelm, Edzard; Boeger, Rainer H.] Univ Med Ctr, Inst Expt & Clin Pharmacol & Toxicol, Hamburg, Germany.
   [Bell, Doris] German Aerosp Ctr, Project Management Agcy, Bonn, Germany.
C3 University of Kiel; Schleswig Holstein University Hospital; University
   of Hamburg; University Medical Center Hamburg-Eppendorf; Helmholtz
   Association; German Aerospace Centre (DLR)
RP Pfeuffer, M (corresponding author), Max Rubner Inst, Dept Physiol & Biochem Nutr, Haid & Neu Str 9, D-76131 Karlsruhe, Germany.
EM maria.pfeuffer@mri.bund.de
RI Giller, Katrin/AAE-6065-2021
OI Giller, Katrin/0000-0002-1276-4548
FU Federal Ministry of Education and Research (BMBF) Germany [AZ
   0312823A/B]; Cognis GmbH Monheim, Germany
FX Source of support: Federal Ministry of Education and Research (BMBF)
   Germany, project grant AZ 0312823A/B: Cognis GmbH Monheim, Germany.
CR AARSMAN AJ, 1991, EUR J BIOCHEM, V200, P187, DOI 10.1111/j.1432-1033.1991.tb21066.x
   Aviram M, 2004, FREE RADICAL BIO MED, V37, P1304, DOI 10.1016/j.freeradbiomed.2004.06.030
   Basu S, 2000, FEBS LETT, V468, P33, DOI 10.1016/S0014-5793(00)01193-5
   Benito P, 2001, LIPIDS, V36, P221, DOI 10.1007/s11745-001-0711-y
   Bhattacharya A, 2005, J NUTR, V135, P1124, DOI 10.1093/jn/135.5.1124
   Bhattacharya A, 2006, J NUTR BIOCHEM, V17, P789, DOI 10.1016/j.jnutbio.2006.02.009
   Bonetti PO, 2003, ARTERIOSCL THROM VAS, V23, P168, DOI 10.1161/01.ATV.0000051384.43104.FC
   Carluccio MA, 2003, ARTERIOSCL THROM VAS, V23, P622, DOI 10.1161/01.ATV.0000062884.69432.A0
   Ceriello A, 2002, CIRCULATION, V106, P1211, DOI 10.1161/01.CIR.0000027569.76671.A8
   Couillard C, 2005, J CLIN ENDOCR METAB, V90, P6454, DOI 10.1210/jc.2004-2438
   Cracowski JL, 2004, EUR HEART J, V25, P1675, DOI 10.1016/j.ehj.2004.07.031
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   Fraley AE, 2006, CURR OPIN LIPIDOL, V17, P502, DOI 10.1097/01.mol.0000245255.40634.b5
   GAN KN, 1991, DRUG METAB DISPOS, V19, P100
   Gaullier JM, 2007, BRIT J NUTR, V97, P550, DOI 10.1017/S0007114507381324
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hamburg NM, 2008, CIRCULATION, V117, P2467, DOI 10.1161/CIRCULATIONAHA.107.748574
   Herrera JA, 2006, AM J HYPERTENS, V19, P381, DOI 10.1016/j.amjhyper.2005.11.004
   Herrmann J, 2009, LIPIDS HEALTH DIS, V8, DOI 10.1186/1476-511X-8-35
   Iannone A, 2009, PROSTAG LEUKOTR ESS, V80, P279, DOI 10.1016/j.plefa.2009.02.008
   Inoue N, 2004, BIOCHEM BIOPH RES CO, V323, P679, DOI 10.1016/j.bbrc.2004.08.139
   Kom GD, 2007, BRIT J CLIN PHARMACO, V63, P672, DOI 10.1111/j.1365-2125.2006.02832.x
   Kuvin JT, 2003, AM HEART J, V146, P168, DOI 10.1016/S0002-8703(03)00094-2
   Lai CH, 2005, J NUTR, V135, P239, DOI 10.1093/jn/135.2.239
   Lambert EV, 2007, BRIT J NUTR, V97, P1001, DOI 10.1017/S0007114507172822
   Mackness B, 1998, FEBS LETT, V423, P57, DOI 10.1016/S0014-5793(98)00064-7
   Meagher EA, 2000, FREE RADICAL BIO MED, V28, P1745, DOI 10.1016/S0891-5849(00)00232-X
   Moloney F, 2004, AM J CLIN NUTR, V80, P887
   Morrow JD, 1997, PROG LIPID RES, V36, P1, DOI 10.1016/S0163-7827(97)00001-5
   Nappo F, 2002, J AM COLL CARDIOL, V39, P1145, DOI 10.1016/S0735-1097(02)01741-2
   Nazare JA, 2007, BRIT J NUTR, V97, P273, DOI 10.1017/S0007114507191911
   Nguyen SD, 2006, BBA-BIOMEMBRANES, V1758, P499, DOI 10.1016/j.bbamem.2006.03.022
   Parra P, 2010, J NUTR BIOCHEM, V21, P107, DOI 10.1016/j.jnutbio.2008.10.010
   Racine NM, 2010, AM J CLIN NUTR, V91, P1157, DOI 10.3945/ajcn.2009.28404
   Raff M, 2006, J NUTR, V136, P992, DOI 10.1093/jn/136.4.992
   Rantala M, 2002, J NUTR, V132, P3012, DOI 10.1093/jn/131.10.3012
   Risérus U, 2004, AM J CLIN NUTR, V80, P279
   Risérus U, 2002, DIABETES CARE, V25, P1516, DOI 10.2337/diacare.25.9.1516
   Risérus U, 2002, CIRCULATION, V106, P1925, DOI 10.1161/01.CIR.0000033589.15413.48
   Rosenblat M, 2006, J BIOL CHEM, V281, P7657, DOI 10.1074/jbc.M512595200
   Ruano J, 2005, J AM COLL CARDIOL, V46, P1864, DOI 10.1016/j.jacc.2005.06.078
   Rubin D, 2010, EUR J ENDOCRINOL, V162, P719, DOI 10.1530/EJE-09-0446
   Schalkwijk CG, 2005, CLIN SCI, V109, P143, DOI 10.1042/CS20050025
   Sies H, 2005, J NUTR, V135, P969, DOI 10.1093/jn/135.5.969
   Sjogren P, 2005, ARTERIOSCL THROM VAS, V25, P2580, DOI 10.1161/01.ATV.0000190675.08857.3d
   Sluijs I, 2010, AM J CLIN NUTR, V91, P175, DOI 10.3945/ajcn.2009.28192
   Smedman A, 2005, BRIT J NUTR, V94, P791, DOI 10.1079/BJN20041419
   Song HJ, 2005, EUR J CLIN NUTR, V59, P508, DOI 10.1038/sj.ejcn.1602102
   Su ND, 2003, LIPIDS, V38, P615, DOI 10.1007/s11745-003-1106-9
   Subbanagounder G, 2000, ARTERIOSCL THROM VAS, V20, P2248, DOI 10.1161/01.ATV.20.10.2248
   Taylor JSW, 2006, ARTERIOSCL THROM VAS, V26, P307, DOI 10.1161/01.ATV.0000199679.40501.ac
   Thom E, 2001, J INT MED RES, V29, P392, DOI 10.1177/147323000102900503
   Thomàs-Moyà E, 2006, J LIPID RES, V47, P2042, DOI 10.1194/jlr.M600215-JLR200
   Tsikas D, 1998, J CHROMATOGR B, V716, P7, DOI 10.1016/S0378-4347(98)00275-8
   Tsikas D, 2003, J CHROMATOGR B, V794, P237, DOI 10.1016/S1570-0232(03)00457-4
   Turpeinen AA, 2008, BRIT J NUTR, V100, P112, DOI 10.1017/S0007114507886326
   Valeille K, 2005, AM J PHYSIOL-HEART C, V289, pH652, DOI 10.1152/ajpheart.00130.2005
   Visioli F, 2005, EUR J NUTR, V44, P121, DOI 10.1007/s00394-004-0504-0
   Watras AC, 2007, INT J OBESITY, V31, P481, DOI 10.1038/sj.ijo.0803437
   Westphal S, 2006, ATHEROSCLEROSIS, V185, P313, DOI 10.1016/j.atherosclerosis.2005.06.004
   Whigham LD, 2007, AM J CLIN NUTR, V85, P1203
NR 61
TC 48
Z9 48
U1 0
U2 14
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0731-5724
EI 1541-1087
J9 J AM COLL NUTR
JI J. Am. Coll. Nutr.
PD FEB
PY 2011
VL 30
IS 1
BP 19
EP 28
DI 10.1080/07315724.2011.10719940
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 791KK
UT WOS:000292663900003
PM 21697535
DA 2025-06-11
ER

PT J
AU Ceja-Galicia, ZA
   Cespedes-Acuña, CLA
   El-Hafidi, M
AF Ceja-Galicia, Zeltzin Alejandra
   Cespedes-Acuna, Carlos Leonardo Armando
   El-Hafidi, Mohammed
TI Protection Strategies Against Palmitic Acid-Induced Lipotoxicity in
   Metabolic Syndrome and Related Diseases
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE antioxidants; lipid droplets; lipotoxicity; metabolic syndrome; obesity;
   oxidative stress; palmitic acid
ID PANCREATIC BETA-CELLS; DE-NOVO LIPOGENESIS; FREE FATTY-ACIDS;
   STEAROYL-COA DESATURASE; INSULIN-SECRETION; SIGNALING PATHWAY; OXIDATIVE
   STRESS; LOW-CARBOHYDRATE; GPR40; LIVER
AB Diets rich in carbohydrate and saturated fat contents, when combined with a sedentary lifestyle, contribute to the development of obesity and metabolic syndrome (MetS), which subsequently increase palmitic acid (PA) levels. At high concentrations, PA induces lipotoxicity through several mechanisms involving endoplasmic reticulum (ER) stress, mitochondrial dysfunction, inflammation and cell death. Nevertheless, there are endogenous strategies to mitigate PA-induced lipotoxicity through its unsaturation and elongation and its channeling and storage in lipid droplets (LDs), which plays a crucial role in sequestering oxidized lipids, thereby reducing oxidative damage to lipid membranes. While extended exposure to PA promotes mitochondrial reactive oxygen species (ROS) generation leading to cell damage, acute exposure of ss-cells to PA increases glucose-stimulated insulin secretion (GSIS), through the activation of free fatty acid receptors (FFARs). Subsequently, the activation of FFARs by exogenous agonists has been suggested as a potential therapeutic strategy to prevent PA-induced lipotoxicity in ss cells. Moreover, some saturated fatty acids, including oleic acid, can counteract the negative impact of PA on cellular health, suggesting a complex interaction between different dietary fats and cellular outcomes. Therefore, the challenge is to prevent the lipid peroxidation of dietary unsaturated fatty acids through the utilization of natural antioxidants. This complexity indicates the necessity for further research into the function of palmitic acid in diverse pathological conditions and to find the main therapeutic target against its lipotoxicity. The aim of this review is, therefore, to examine recent data regarding the mechanism underlying PA-induced lipotoxicity in order to identify strategies that can promote protection mechanisms against lipotoxicity, dysfunction and apoptosis in MetS and obesity.
C1 [Ceja-Galicia, Zeltzin Alejandra; El-Hafidi, Mohammed] Inst Nacl Cardiol Ignacio Chavez, Dept Biomed Cardiovasc, Mexico City 14080, Mexico.
   [Cespedes-Acuna, Carlos Leonardo Armando] Univ Bio Bio, Fac Ciencias, Dept Ciencias Basicas, Ave Andres Bello 720, Chillan 3780708, Chile.
C3 National Institute of Cardiology - Mexico; Universidad del Bio-Bio
RP El-Hafidi, M (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Biomed Cardiovasc, Mexico City 14080, Mexico.
EM alejandra.ceja@cardiologia.org.mx; ccespedes@ubiobio.cl;
   mohammed.elhafidi@cardiologia.org.mx
RI Cespedes-Acuna, Carlos/D-3138-2013
OI Cespedes-Acuna, Carlos/0000-0002-3715-3268; Ceja Galicia, Zeltzin
   Alejandra/0000-0002-0874-1845
CR Abbasi MSP, 2022, PHYSIOL REP, V10, DOI 10.14814/phy2.15375
   Al Mahri S, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11040750
   Alizadeh J, 2023, EUR J CELL BIOL, V102, DOI 10.1016/j.ejcb.2023.151337
   Alnahdi A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11091979
   Alvheim AR, 2012, OBESITY, V20, P1984, DOI 10.1038/oby.2012.38
   Amine H, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-85018-7
   Apekey TA, 2022, NUTRIENTS, V14, DOI 10.3390/nu14204391
   Araki T, 2012, DIABETES OBES METAB, V14, P271, DOI 10.1111/j.1463-1326.2011.01525.x
   Arora M, 2023, BIOMED PHARMACOTHER, V167, DOI 10.1016/j.biopha.2023.115447
   Baldwin AC, 2012, AM J PHYSIOL-ENDOC M, V302, pE1390, DOI 10.1152/ajpendo.00519.2011
   Barrios-Maya MA, 2021, FOOD CHEM TOXICOL, V154, DOI 10.1016/j.fct.2021.112351
   Bayram I, 2023, TRENDS FOOD SCI TECH, V133, P219, DOI 10.1016/j.tifs.2023.02.003
   Benhamed F, 2012, J CLIN INVEST, V122, P2176, DOI 10.1172/JCI41636
   Bi CH, 2020, CHEM RES TOXICOL, V33, P3031, DOI 10.1021/acs.chemrestox.0c00372
   Briscoe CP, 2003, J BIOL CHEM, V278, P11303, DOI 10.1074/jbc.M211495200
   Cabodevilla AG, 2024, CURR OPIN LIPIDOL, V35, P85, DOI 10.1097/MOL.0000000000000918
   Cerk IK, 2018, CURR PROTEIN PEPT SC, V19, P221, DOI 10.2174/1389203718666170918160110
   Chang YC, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19103010
   Chen QQ, 2019, FREE RADICAL BIO MED, V130, P48, DOI 10.1016/j.freeradbiomed.2018.10.419
   Chen X, 2024, COMMUN BIOL, V7, DOI 10.1038/s42003-024-06248-9
   Chen XM, 2018, LIFE SCI, V203, P291, DOI 10.1016/j.lfs.2018.04.022
   Chen Z, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11071387
   Cheon HG, 2014, J BIOMED SCI, V21, DOI 10.1186/1423-0127-21-13
   Cho YS, 2012, MOL CELL BIOCHEM, V364, P19, DOI 10.1007/s11010-011-1200-z
   Chong MFF, 2008, AM J CLIN NUTR, V87, P817, DOI 10.1093/ajcn/87.4.817
   Chong YM, 2015, FOOD BIOSCI, V12, P18, DOI 10.1016/j.fbio.2015.07.002
   Cnop M, 2001, DIABETES, V50, P1771, DOI 10.2337/diabetes.50.8.1771
   Dadsena S, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-09654-4
   Danielli M, 2023, FRONT CELL DEV BIOL, V11, DOI 10.3389/fcell.2023.1104725
   de Souza CO, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700504
   Den Hartogh DJ, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24065094
   Dibwe DF, 2024, ANTIOXIDANTS-BASEL, V13, DOI 10.3390/antiox13050513
   Dikalov S, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25126498
   Dong GF, 2023, CELL METAB, V35, P332, DOI 10.1016/j.cmet.2022.12.012
   Dragano NRV, 2024, MOL METAB, V79, DOI 10.1016/j.molmet.2023.101840
   Drizyte-Miller Kristina, 2020, Contact (Thousand Oaks), V3, P1, DOI 10.1177/2515256420910892
   El Hafidi M, 2001, J NUTR BIOCHEM, V12, P396, DOI 10.1016/S0955-2863(01)00154-1
   El-Hafidi M, 2020, BBA-MOL BASIS DIS, V1866, DOI 10.1016/j.bbadis.2020.165744
   Engin AB, 2017, ADV EXP MED BIOL, V960, P197, DOI 10.1007/978-3-319-48382-5_8
   Fauconnier J, 2007, DIABETES, V56, P1136, DOI 10.2337/db06-0739
   Feingold KR, 2022, ENDOCRIN METAB CLIN, V51, P437, DOI 10.1016/j.ecl.2022.02.008
   Feng RF, 2024, FOOD BIOSCI, V61, DOI 10.1016/j.fbio.2024.104882
   Ferrara PJ, 2021, J CLIN INVEST, V131, DOI 10.1172/JCI135963
   Ferré P, 2021, BIOCHEM J, V478, P3723, DOI 10.1042/BCJ20210071
   Garcia-Martinez I, 2023, JHEP REP, V5, DOI 10.1016/j.jhepr.2023.100756
   Gehrmann W, 2010, DIABETES OBES METAB, V12, P149, DOI 10.1111/j.1463-1326.2010.01265.x
   Gosis BS, 2022, SCIENCE, V376, P264, DOI 10.1126/science.abf8271
   Graciano MF, 2013, ISLETS, V5, P139, DOI 10.4161/isl.25459
   Granieri Maria Concetta, 2023, Int J Environ Res Public Health, V20, DOI 10.3390/ijerph20043492
   Guichardant M, 2006, PROSTAG LEUKOTR ESS, V75, P179, DOI 10.1016/j.plefa.2006.05.006
   Guo MJ, 2024, EXP CELL RES, V440, DOI 10.1016/j.yexcr.2024.114134
   Haffar T, 2016, CELL PHYSIOL BIOCHEM, V40, P969, DOI 10.1159/000453154
   Hall KD, 2018, CURR OPIN CLIN NUTR, V21, P308, DOI 10.1097/MCO.0000000000000470
   Heilig R, 2023, BIOCHEM SOC T, V51, P457, DOI 10.1042/BST20221525
   Huang CY, 2023, FOOD CHEM TOXICOL, V171, DOI 10.1016/j.fct.2022.113554
   Hyde PN, 2019, JCI INSIGHT, V4, DOI 10.1172/jci.insight.128308
   Imierska M, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11071123
   Ismael SA, 2021, BMC NUTR, V7, DOI 10.1186/s40795-021-00466-8
   Itoh Y, 2003, NATURE, V422, P173, DOI 10.1038/nature01478
   Jarc E, 2019, YALE J BIOL MED, V92, P435
   Jiang QY, 2024, FOOD BIOSCI, V60, DOI 10.1016/j.fbio.2024.104482
   Jiménez-González S, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9020451
   Kang BB, 2019, FOOD BIOSCI, V28, P1, DOI 10.1016/j.fbio.2018.12.001
   Kennedy A, 2009, J NUTR, V139, P1, DOI 10.3945/jn.108.098269
   Kim CS, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20143386
   Kim HS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0050128
   Kimura I, 2020, PHYSIOL REV, V100, P171, DOI 10.1152/physrev.00041.2018
   Korbecki J, 2019, INFLAMM RES, V68, P915, DOI 10.1007/s00011-019-01273-5
   Kristinsson H, 2015, BBA-MOL CELL RES, V1853, P3248, DOI 10.1016/j.bbamcr.2015.09.022
   Kristinsson H, 2013, ENDOCRINOLOGY, V154, P4078, DOI 10.1210/en.2013-1352
   Kuang H, 2023, FEBS J, V290, P3664, DOI 10.1111/febs.16772
   Lallement J., 2021, bioRxiv, DOI [10.1101/2021.09.16.460588, DOI 10.1101/2021.09.16.460588]
   Lambertucci RH, 2012, CELL PHYSIOL BIOCHEM, V30, P1169, DOI 10.1159/000343307
   Larsson K, 2016, FOOD FUNCT, V7, P1176, DOI [10.1039/c5fo01401h, 10.1039/C5FO01401H]
   Latour MG, 2007, DIABETES, V56, P1087, DOI 10.2337/db06-1532
   Leifke E, 2012, CLIN PHARMACOL THER, V92, P29, DOI 10.1038/clpt.2012.43
   Lenighan YM, 2019, P NUTR SOC, V78, P234, DOI 10.1017/S0029665118002793
   Li H, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.00081
   Li NS, 2018, BIOCHEMISTRY-US, V57, P72, DOI 10.1021/acs.biochem.7b00975
   Li YG, 2022, FRONT PHYSIOL, V13, DOI 10.3389/fphys.2022.826314
   Lin P., 2018, The Molecular Nutrition of Fats
   Listenberger LL, 2003, P NATL ACAD SCI USA, V100, P3077, DOI 10.1073/pnas.0630588100
   Liu BB, 2020, BIOMED PHARMACOTHER, V125, DOI 10.1016/j.biopha.2020.109895
   Liu RZ, 2020, ENVIRON SCI TECHNOL, V54, P11706, DOI 10.1021/acs.est.0c05077
   Ljubkovic M, 2019, DIABETES, V68, P1924, DOI 10.2337/db19-0423
   Longhitano L, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms241914491
   Ma XM, 2023, CELL BIOL TOXICOL, V39, P277, DOI 10.1007/s10565-021-09692-z
   Magtanong L, 2019, CELL CHEM BIOL, V26, P420, DOI 10.1016/j.chembiol.2018.11.016
   Mansuri ML, 2021, J BIOCHEM MOL TOXIC, V35, DOI 10.1002/jbt.22744
   Marafie SK, 2019, BIOL RES, V52, DOI 10.1186/s40659-019-0253-4
   Martínez L, 2015, ONCOTARGET, V6, P41479, DOI 10.18632/oncotarget.6286
   Martínez-García C, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0142291
   Miklankova D, 2022, J DIABETES RES, V2022, DOI 10.1155/2022/4587907
   Monçao ÉD, 2022, FOOD BIOSCI, V45, DOI 10.1016/j.fbio.2021.101370
   Moon YA, 2014, J LIPID RES, V55, P2597, DOI 10.1194/jlr.M054353
   Moumtaz S, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-39767-1
   Mthembu Sinenhlanhla X H, 2024, Toxicol Rep, V12, P234, DOI 10.1016/j.toxrep.2024.01.014
   Murru E, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.861664
   Nakamura M, 2020, J PHYSIOL-LONDON, V598, P2977, DOI 10.1113/JP276747
   Nie CZP, 2021, FOOD BIOSCI, V40, DOI 10.1016/j.fbio.2021.100893
   Nyanhongo GS, 2013, EUR J PHARM BIOPHARM, V83, P396, DOI 10.1016/j.ejpb.2012.10.013
   Obaseki E, 2024, FEBS LETT, V598, P1207, DOI 10.1002/1873-3468.14808
   Oemer G, 2021, J LIPID RES, V62, DOI 10.1016/j.jlr.2021.100111
   Pan XY, 2023, MOL MED REP, V28, DOI 10.3892/mmr.2023.13068
   Pan Y, 2019, J CLIN INVEST, V129, P834, DOI 10.1172/JCI123069
   Panov A, 2018, MOL BIOL+, V52, P295, DOI 10.1134/S0026893318020097
   Panov A, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23074047
   Park EJ, 2014, FOOD CHEM TOXICOL, V67, P26, DOI 10.1016/j.fct.2014.01.027
   Pérez M, 2023, J AGR FOOD CHEM, V71, P17543, DOI 10.1021/acs.jafc.3c04022
   Petan T, 2018, MOLECULES, V23, DOI 10.3390/molecules23081941
   Platzer M, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.882458
   Poudyal Hemant, 2011, Endocrine Metabolic & Immune Disorders-Drug Targets, V11, P217
   Qiu TT, 2022, NUTR DIABETES, V12, DOI 10.1038/s41387-022-00202-6
   Rahmani-Manglano NE, 2023, FOOD BIOSCI, V56, DOI 10.1016/j.fbio.2023.103074
   Raja AA, 2022, GENES-BASEL, V13, DOI 10.3390/genes13101704
   Ravaut G, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22010330
   Régnier M, 2023, NAT REV ENDOCRINOL, V19, P336, DOI 10.1038/s41574-023-00809-4
   Ren G, 2020, AM J PHYSIOL-ENDOC M, V319, pE893, DOI 10.1152/ajpendo.00117.2020
   Ren Y, 2013, J AGR FOOD CHEM, V61, P11595, DOI 10.1021/jf403039m
   Rocca C, 2023, CELLS-BASEL, V12, DOI 10.3390/cells12071042
   Ruiz M, 2021, LIPIDS HEALTH DIS, V20, DOI 10.1186/s12944-021-01600-y
   Ruiz-Ramírez A, 2015, AM J PHYSIOL-ENDOC M, V309, pE777, DOI 10.1152/ajpendo.00617.2014
   Ruiz-Ramírez A, 2011, AM J PHYSIOL-ENDOC M, V301, pE1198, DOI 10.1152/ajpendo.00631.2010
   Sakuma K, 2016, PHARMACOL RES PERSPE, V4, DOI 10.1002/prp2.237
   Samaha FF, 2003, NEW ENGL J MED, V348, P2074, DOI 10.1056/NEJMoa022637
   Sano M, 2020, J REPROD DEVELOP, V66, P241, DOI 10.1262/jrd.2020-007
   Sapandowski A, 2015, MOL CELL BIOCHEM, V410, P175, DOI 10.1007/s11010-015-2549-1
   Schwarz JM, 2003, AM J CLIN NUTR, V77, P43, DOI 10.1093/ajcn/77.1.43
   Schweiger M, 2006, J BIOL CHEM, V281, P40236, DOI 10.1074/jbc.M608048200
   Sergi D, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.663838
   Shahid MS, 2022, FOODS, V11, DOI 10.3390/foods11203158
   Shapiro H, 2005, BIOCHEM BIOPH RES CO, V335, P97, DOI 10.1016/j.bbrc.2005.07.042
   Sharifi S, 2024, REDOX BIOL, V73, DOI 10.1016/j.redox.2024.103170
   Shen XM, 2014, METABOLISM, V63, P335, DOI 10.1016/j.metabol.2013.11.003
   Shilovsky GA, 2019, BIOCHEMISTRY-MOSCOW+, V84, P1469, DOI 10.1134/S000629791912006X
   Smith GI, 2020, J CLIN INVEST, V130, P1453, DOI 10.1172/JCI134165
   Song YF, 2024, J NUTR BIOCHEM, V126, DOI 10.1016/j.jnutbio.2023.109559
   Sosa EIF, 2024, FOOD BIOSCI, V60, DOI 10.1016/j.fbio.2024.104489
   Tang C, 2024, FOOD BIOSCI, V59, DOI 10.1016/j.fbio.2024.104261
   Tang YD, 2024, J LIPID RES, V65, DOI 10.1016/j.jlr.2024.100587
   Tanwar VS, 2023, ARTERIOSCL THROM VAS, V43, P1157, DOI 10.1161/ATVBAHA.122.318536
   Tokarz VL, 2023, J CELL SCI, V136, DOI 10.1242/jcs.261300
   Tong TT, 2018, MOLECULES, V23, DOI 10.3390/molecules23123382
   Trexler AJ, 2017, CELL CALCIUM, V67, P1, DOI 10.1016/j.ceca.2017.07.008
   Trombetta A, 2013, DIABETES, V62, P1245, DOI 10.2337/db12-0646
   Tuo Y, 2012, CLIN EXP PHARMACOL P, V39, P423, DOI 10.1111/j.1440-1681.2012.05691.x
   Turpaev KT, 2013, BIOCHEMISTRY-MOSCOW+, V78, P111, DOI 10.1134/S0006297913020016
   Venkatraman K, 2024, J LIPID RES, V65, DOI 10.1016/j.jlr.2024.100601
   Vilas-Boas EA, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10123328
   Wang J, 2020, EXP BIOL MED, V245, P1268, DOI 10.1177/1535370220928276
   Wang XQ, 2024, NAT COMMUN, V15, DOI 10.1038/s41467-024-45582-8
   Wang Y, 2019, CLIN SCI, V133, P101, DOI 10.1042/CS20180836
   Wang Y, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms13997
   Wang Y, 2006, J LIPID RES, V47, P2028, DOI 10.1194/jlr.M600177-JLR200
   Wei CD, 2013, MOL MED REP, V7, P855, DOI 10.3892/mmr.2013.1276
   Wong KL, 2014, PHARMACOL REP, V66, P1106, DOI 10.1016/j.pharep.2014.07.009
   Wu HZ, 2022, COMPR REV FOOD SCI F, V21, P1275, DOI 10.1111/1541-4337.12890
   Wu PW, 2010, BIOCHEM BIOPH RES CO, V403, P36, DOI 10.1016/j.bbrc.2010.10.105
   Wu ZM, 2022, TOXICOL APPL PHARM, V436, DOI 10.1016/j.taap.2021.115858
   Xi BN, 2024, FOOD BIOSCI, V61, DOI 10.1016/j.fbio.2024.104788
   Xia MM, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12111922
   Xu DJ, 2020, J PINEAL RES, V69, DOI 10.1111/jpi.12690
   Xu XQ, 2021, FOOD CHEM, V353, DOI 10.1016/j.foodchem.2021.129488
   Yang HY, 2022, LIFE-BASEL, V12, DOI 10.3390/life12020182
   Yang L, 2019, BIOSCIENCE REP, V39, DOI 10.1042/BSR20190225
   Yang LL, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201801432
   Yoon HJ, 2018, FOOD BIOSCI, V25, P61, DOI 10.1016/j.fbio.2018.08.002
   Yu GW, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20246268
   Yuan Y, 2024, SIGNAL TRANSDUCT TAR, V9, DOI 10.1038/s41392-024-01759-7
   Zacharewicz E, 2018, J INTERN MED, V284, P505, DOI 10.1111/joim.12729
   Zadoorian A, 2023, NAT REV ENDOCRINOL, V19, P443, DOI 10.1038/s41574-023-00845-0
   Zhang XY, 2022, DIABET METAB SYND OB, V15, P2287, DOI 10.2147/DMSO.S360931
   Zhao PX, 2022, NANOMATERIALS-BASEL, V12, DOI 10.3390/nano12040672
   Zuccaro KE, 2024, bioRxiv, DOI [10.1101/2024.05.21.595226, 10.1101/2024.05.21.595226, DOI 10.1101/2024.05.21.595226]
NR 174
TC 4
Z9 4
U1 6
U2 6
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2025
VL 26
IS 2
AR 788
DI 10.3390/ijms26020788
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA T3U7J
UT WOS:001404304800001
PM 39859502
OA gold
DA 2025-06-11
ER

PT J
AU Najafi, A
   Pourfarzam, M
   Zadhoush, F
AF Najafi, Ali
   Pourfarzam, Morteza
   Zadhoush, Fouzieh
TI Oxidant/antioxidant status in Type-2 diabetes mellitus patients with
   metabolic syndrome
SO JOURNAL OF RESEARCH IN MEDICAL SCIENCES
LA English
DT Article
DE Diabetes mellitus Type 2; metabolic syndrome; oxidative stress;
   sodium-potassium-exchanging ATPase
ID OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; LIPID-PEROXIDATION;
   ASSOCIATION; INFLAMMATION; PREVALENCE; MEMBRANE; GLUCOSE; BLOOD
AB Background: The concurrence of metabolic syndrome (MS) and diabetes mellitus (DM) is increasing worldwide. The long-term complications of these chronic diseases are a threat to patients' well-being. Oxidative stress is involved in the pathogenesis of several diseases. To understand the basic pathophysiological mechanisms of Type-2 DM (T2DM) and its related complications, we aimed to investigate the oxidant/antioxidant status and Na+-K+ ATPase activity in T2DM with MS. Materials and Methods: A population of ninety individuals including fifty patients diagnosed with T2DM and MS, but without overt diabetes complications, and forty individuals without T2DM or MS as control group participated in this study. Plasma malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) activities, total antioxidant capacity (TAC), and Na+-K+ ATPase activity were assessed by standard laboratory methods. Results: Plasma MDA in patients group was statistically significantly higher than that of controls (P <= 0.05). Whereas, Na+-K+ ATPase activity was statistically significantly lower in patient group (P <= 0.05). TAC, CAT, SOD, and GPx enzyme activities were not statistically significantly different between two groups (P > 0.05). Results from the patient group showed positive correlations between CAT activity and triglyceride and positive correlations between GPx activity and weight, body mass index (BMI), and waist circumference. In addition, there was a positive correlation between MDA results with high-density lipoprotein-cholesterol (HDL-C) and total cholesterol and a negative correlation with TAC, BMI, and weight (P <= 0.05) in controls. Conclusion: Because T2DM patients were without any vascular complications, antioxidant defense results may reflect the lack of progression of diabetes complications in these patients. These results emphasize the need for initial and continued assessment of cardiovascular disease risks in diabetic individuals. Implementation of timely interventions may improve the management of diabetes and prevent the progression of diabetes complications.
C1 [Najafi, Ali; Pourfarzam, Morteza; Zadhoush, Fouzieh] Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Clin Biochem, Esfahan, Iran.
C3 Isfahan University of Medical Sciences
RP Zadhoush, F (corresponding author), Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Clin Biochem, Esfahan, Iran.
EM f.zadhoush@pharm.mui.ac.ir
RI zadhoush, fouzieh/S-4976-2018
FU Isfahan University of Medical Sciences [397683]
FX This study was supported by grants from Isfahan University of Medical
   Sciences (grant no. 397683).
CR Bigagli E, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/5953685
   Cardona F, 2008, EUR J CLIN INVEST, V38, P510, DOI 10.1111/j.1365-2362.2008.01959.x
   Cefalu WT, 2019, DIABETES CARE, V42, pS34, DOI 10.2337/dc19-S004
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Darroudi S, 2019, BIOFACTORS, V45, P35, DOI 10.1002/biof.1459
   Ebrahimi H, 2019, J RES MED SCI, V24, DOI 10.4103/jrms.JRMS_858_18
   Egea J, 2017, REDOX BIOL, V13, P94, DOI 10.1016/j.redox.2017.05.007
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   Ferder L, 2006, CURR HYPERTENS REP, V8, P191, DOI 10.1007/s11906-006-0050-7
   Fiske CH, 1925, J BIOL CHEM, V66, P375
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gao CL, 2010, MOL CELL ENDOCRINOL, V320, P25, DOI 10.1016/j.mce.2010.01.039
   Goli P, 2020, J RES MED SCI, V25, DOI 10.4103/jrms.JRMS_733_19
   Guariguata L, 2014, DIABETES RES CLIN PR, V103, P137, DOI 10.1016/j.diabres.2013.11.002
   Incalza MA, 2018, VASC PHARMACOL, V100, P1, DOI 10.1016/j.vph.2017.05.005
   Jain SK, 2000, FREE RADICAL BIO MED, V29, P1122, DOI 10.1016/S0891-5849(00)00410-X
   MARKWELL MAK, 1978, ANAL BIOCHEM, V87, P206, DOI 10.1016/0003-2697(78)90586-9
   Marrocco I, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/6501046
   Namazi G, 2015, CORONARY ARTERY DIS, V26, P239, DOI 10.1097/MCA.0000000000000196
   Newsholme P, 2019, AM J PHYSIOL-CELL PH, V317, pC420, DOI 10.1152/ajpcell.00141.2019
   Pourfarzam Morteza, 2016, Adv Biomed Res, V5, P153
   Ruderman NB, 2013, J CLIN INVEST, V123, P2764, DOI 10.1172/JCI67227
   Sabir AA, 2016, NIGER J CLIN PRACT, V19, P128, DOI 10.4103/1119-3077.173705
   Shahid Syed Mohammad, 2005, Pak J Pharm Sci, V18, P6
   Shim WS, 2006, DIABETES RES CLIN PR, V73, P284, DOI 10.1016/j.diabres.2006.02.001
   Yang M, 2006, AM J HYPERTENS, V19, P587, DOI 10.1016/j.amjhyper.2005.11.017
   Yokota T, 2013, DIABETES CARE, V36, P1341, DOI 10.2337/dc12-1161
   Zadhoush F, 2015, J RES MED SCI, V20, P763, DOI 10.4103/1735-1995.168383
NR 28
TC 9
Z9 10
U1 0
U2 1
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 1735-1995
EI 1735-7136
J9 J RES MED SCI
JI J. Res. Med. Sci.
PD JAN-DEC
PY 2021
VL 26
IS 1
DI 10.4103/jrms.JRMS_249_20
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA QQ6KF
UT WOS:000624631200006
PM 34084185
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhou, Y
   Yang, GF
   Peng, W
   Zhang, HL
   Peng, ZY
   Ding, N
   Guo, T
   Cai, YZ
   Deng, QJ
   Chai, XP
AF Zhou, Yang
   Yang, Guifang
   Peng, Wen
   Zhang, Hongliang
   Peng, Zhenyu
   Ding, Ning
   Guo, Tao
   Cai, Yuzhong
   Deng, Qijian
   Chai, Xiangping
TI Relationship between Depression Symptoms and Different Types of Measures
   of Obesity (BMI, SAD) in US Women
SO BEHAVIOURAL NEUROLOGY
LA English
DT Article
ID SAGITTAL ABDOMINAL DIAMETER; BODY-MASS INDEX; METABOLIC SYNDROME;
   RISK-FACTORS; DISORDERS; AGE; ASSOCIATION; COMORBIDITY; PREVALENCE;
   HEALTH
AB Objective. To estimate the relationship between obesity (defined by both BMI and SAD) and various levels of depressive symptoms in women in the United States. Methods. This is a cross-sectional design. All data were collected from NHANES 2011-2012 and 2013-2014. The Patient Health Questionnaire (PHQ-9) was the primary variable used to index depressive symptoms. SAD was assessed using an abdominal caliper. We stratified participates into three groups according to SAD (trisection): T1: low (11.8-18.4 cm), T2: middle (18.5-22.8 cm), and T3: high (22.9-40.1 cm). Other data were collected following the NHANES protocols. We aimed to investigate the effects of obesity on the depression in the NHANES populations. Results. A total of 4477 women were enrolled in the final study population. Participants with a high SAD had the highest risk of clinical depression symptoms (OR=1.2, 95% CI: 1.1-1.4), which was, in particular, the case for moderate-severe depression (OR=1.4, 95% CI: 1.1-1.7) and severe depression (OR=1.4, 95% CI: 1.0-1.9). We also found a significant relationship between SAD and BMI (r=0.836). We did, however, not find a significant relationship between BMI and severe depression. Conclusions. SAD had a better correlation with clinical depression symptoms than BMI, especially regarding severe depression symptoms.
C1 [Zhou, Yang; Yang, Guifang; Peng, Wen; Zhang, Hongliang; Peng, Zhenyu; Ding, Ning; Guo, Tao; Cai, Yuzhong; Chai, Xiangping] Cent South Univ, Xiangya Hosp 2, Dept Emergency Med, Changsha, Peoples R China.
   [Zhou, Yang; Yang, Guifang; Peng, Wen; Zhang, Hongliang; Peng, Zhenyu; Ding, Ning; Guo, Tao; Cai, Yuzhong; Chai, Xiangping] Cent South Univ, Xiangya Hosp 2, Emergency Med & Difficult Dis Inst, Changsha, Peoples R China.
   [Deng, Qijian] Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Peoples R China.
C3 Central South University; Central South University; Central South
   University
RP Chai, XP (corresponding author), Cent South Univ, Xiangya Hosp 2, Dept Emergency Med, Changsha, Peoples R China.; Chai, XP (corresponding author), Cent South Univ, Xiangya Hosp 2, Emergency Med & Difficult Dis Inst, Changsha, Peoples R China.; Deng, QJ (corresponding author), Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Peoples R China.
EM zhouzhou1107@csu.edu.cn; yangguifang@csu.edu.cn; fenghuaxuepiao@qq.com;
   zhanghongliang@csu.edu.cn; pengzhenyu1999@csu.edu.cn;
   doctordingning@csu.edu.cn; guotao17@csu.edu.cn; 188202152@csu.edu.cn;
   dengqijian@csu.edu.cn; chaixiangping@csu.edu.cn
RI Yang, Gui/KXQ-7081-2024
FU Natural Science Foundation of Hunan Province, China [2019JJ40451];
   National Natural Science Foundation of China [81100221]
FX The authors thank all the participants in NHANES. This work was
   supported by the Natural Science Foundation of Hunan Province, China
   (Grant No. 2019JJ40451) and the National Natural Science Foundation of
   China (Grant No. 81100221).
CR Ahmadi SS, 2019, OBES SCI PRACT, V5, P130, DOI 10.1002/osp4.324
   Ali MK, 2020, JAMA-J AM MED ASSOC, V324, P651, DOI 10.1001/jama.2020.11747
   Chen NS, 2020, LANCET, V395, P507, DOI 10.1016/S0140-6736(20)30211-7
   de Souza NC, 2013, J DIABETES METAB DIS, V12, DOI 10.1186/2251-6581-12-41
   Everson-Rose SA, 2009, PSYCHOSOM MED, V71, P410, DOI 10.1097/PSY.0b013e3181a20c9c
   Firouzi SA, 2018, J DIABETES RES, V2018, DOI 10.1155/2018/3604108
   Fox CS, 2007, CIRCULATION, V116, P39, DOI 10.1161/CIRCULATIONAHA.106.675355
   Goldstein LT, 1996, INT J EAT DISORDER, V20, P191, DOI 10.1002/(SICI)1098-108X(199609)20:2<191::AID-EAT10>3.0.CO;2-6
   Haynes A, 2019, CLIN PSYCHOL REV, V73, DOI 10.1016/j.cpr.2019.101753
   Heo M, 2006, INT J OBESITY, V30, P513, DOI 10.1038/sj.ijo.0803122
   Jackson SE, 2019, DEPRESS ANXIETY, V36, P987, DOI 10.1002/da.22950
   Kahn HS, 2016, AM J MED, V129, P74, DOI 10.1016/j.amjmed.2015.08.010
   Kahn HS, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0108707
   Ko JY, 2012, J WOMENS HEALTH, V21, P830, DOI 10.1089/jwh.2011.3466
   Lasselin J, 2014, NEUROIMMUNOMODULAT, V21, P95, DOI 10.1159/000356535
   Linde JA, 2011, ANN BEHAV MED, V41, P119, DOI 10.1007/s12160-010-9232-2
   McElroy SL, 2015, J CLIN PSYCHIAT, V76, pE1340, DOI 10.4088/JCP.14com09722
   McHugh RK, 2013, J CLIN PSYCHIAT, V74, P595, DOI 10.4088/JCP.12r07757
   McLean CP, 2011, J PSYCHIATR RES, V45, P1027, DOI 10.1016/j.jpsychires.2011.03.006
   Milaneschi Y, 2019, MOL PSYCHIATR, V24, P18, DOI 10.1038/s41380-018-0017-5
   Nguyen B, 2017, J AFFECT DISORDERS, V223, P209, DOI 10.1016/j.jad.2017.07.019
   Olvera RL, 2015, J CLIN PSYCHIAT, V76, pE1300, DOI 10.4088/JCP.14m09118
   Onyike CU, 2003, AM J EPIDEMIOL, V158, P1139, DOI 10.1093/aje/kwg275
   Patel JS, 2019, DEPRESS ANXIETY, V36, P813, DOI 10.1002/da.22940
   Penninx BWJH, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-129
   Pratt Laura A, 2014, NCHS Data Brief, P1
   Rivenes AC, 2009, J PSYCHOSOM RES, V66, P269, DOI 10.1016/j.jpsychores.2008.07.012
   Shah Ravi V, 2014, JACC Cardiovasc Imaging, V7, P1221, DOI 10.1016/j.jcmg.2014.07.017
   Shi D, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000021647
   Staiano AE, 2016, OBESITY, V24, P1969, DOI 10.1002/oby.21567
   Stein AD, 2007, AM J CLIN NUTR, V85, P869, DOI 10.1093/ajcn/85.3.869
   Tanaka R, 2018, J MED INTERNET RES, V20, DOI 10.2196/jmir.8757
   Vogelzangs N, 2008, ARCH GEN PSYCHIAT, V65, P1386, DOI 10.1001/archpsyc.65.12.1386
   Xiao H, 2018, INT UROL NEPHROL, V50, P1679, DOI 10.1007/s11255-018-1861-6
   Zhang JC, 2016, SCI REP-UK, V6, DOI 10.1038/srep36705
   Zhao K, 2020, BMC PSYCHIATRY, V20, DOI 10.1186/s12888-020-02791-x
NR 36
TC 11
Z9 11
U1 2
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0953-4180
EI 1875-8584
J9 BEHAV NEUROL
JI Behav. Neurol.
PD NOV 23
PY 2020
VL 2020
AR 9624106
DI 10.1155/2020/9624106
PG 10
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA PE5GX
UT WOS:000598395200001
PM 33299495
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Perez-Diaz, C
   Uriz-Martínez, M
   Ortega-Rico, C
   Leno-Duran, E
   Barrios-Rodrígueza, R
   Salcedo-Bellido, I
   Arrebola, JP
   Requena, P
AF Perez-Diaz, Celia
   Uriz-Martinez, Maialen
   Ortega-Rico, Carmen
   Leno-Duran, Ester
   Barrios-Rodrigueza, Rocio
   Salcedo-Bellido, Inmaculada
   Arrebola, Juan Pedro
   Requena, Pilar
TI Phthalate exposure and risk of metabolic syndrome components: A
   systematic review
SO ENVIRONMENTAL POLLUTION
LA English
DT Review
DE Phthalate exposure; Human; Metabolic syndrome; Systematic review
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; CRITICAL WINDOWS; BODY-SIZE;
   URINARY CONCENTRATIONS; CHILDRENS HEALTH; BISPHENOL-A; CHILDHOOD;
   ASSOCIATION; OBESITY
AB Metabolic syndrome is a cluster of conditions that increase the risk of cardiovascular disease, i.e. obesity, insulin resistance, hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL-c) levels and arterial hypertension. Phthalates are environmental chemicals which might influence the risk of the aforementioned disturbances, although the evidence is still controversial. The objective of this work was to synthesize the evidence on the association between human phthalate exposure and metabolic syndrome or any of its components. In this systematic review, the PRISMA guidelines were followed and the literature was search in PubMed, Web of Science and Scopus. Longitudinal and cross-sectional studies were included, the later only if a subclinical marker of disease was evaluated. The methodological quality was assessed with the Newcastle Ottawa Scale and a checklist for Analytical Cross-Sectional Studies developed in the Joanna Briggs Institute. A total of 58 articles were identified that showed high heterogenicity in the specific phthalates assessed, time-window of exposure and duration of follow-up. The quality of the studies was evaluated as high (n = 46, score >7 points) or medium (n = 12, score 4-6). The most frequently studied phthalates were DEHP-MEHP, MBzP and MEP. The evidence revealed a positive association between prenatal (in utero) exposure to most phthalates and markers of obesity in the offspring, but contradictory results when postnatal exposure and obesity were assessed. Moreover, postnatal phthalate exposure showed positive and very consistent associations with markers of diabetes and, to a lesser extent, with triglyceride levels. However, fewer evidence and contradictory results were found for HDL-c levels and markers of hypertension. The suggested mechanisms for these metabolic effects include transcription factor PPAR activation, antagonism of thyroid hormone function, antiandrogenic effects, oxidative stress and inflammation, and epigenetic changes. Nevertheless, as the inconsistency of some results could be related to differences in the study design, future research should aim to standardise the exposure assessment.
C1 [Perez-Diaz, Celia; Uriz-Martinez, Maialen; Ortega-Rico, Carmen; Barrios-Rodrigueza, Rocio; Salcedo-Bellido, Inmaculada; Arrebola, Juan Pedro; Requena, Pilar] Univ Granada, Pharm Sch, Dept Prevent Med & Publ Hlth, Campus Cartuja S-N, Granada 18071, Spain.
   [Perez-Diaz, Celia; Barrios-Rodrigueza, Rocio; Salcedo-Bellido, Inmaculada; Arrebola, Juan Pedro; Requena, Pilar] Inst Invest Biosanit Ibs GRANADA, Avda Madrid 15,Pabellon Consultas Externas 2,2 Pla, Granada 18012, Spain.
   [Leno-Duran, Ester] Univ Granada, Med Sch, Dept Obstet & Gynaecol, Parque Tecnol Salud,Ave Invest 11, Granada 18016, Spain.
   [Barrios-Rodrigueza, Rocio; Salcedo-Bellido, Inmaculada; Arrebola, Juan Pedro; Requena, Pilar] Inst Salud Carlos III, Consortium Biomed Res Epidemiol & Publ Hlth CIBERE, C Monforte de Lemos 3-5,Pabellon 11 Planta 0, Madrid 28029, Spain.
   [Leno-Duran, Ester] Fac Med, Dept Obstet & Ginecol, Ave Invest 11, Granada 18016, Spain.
C3 University of Granada; Instituto de Investigacion Biosanitaria IBS
   Granada; University of Granada; Instituto de Salud Carlos III
RP Leno-Duran, E (corresponding author), Fac Med, Dept Obstet & Ginecol, Ave Invest 11, Granada 18016, Spain.
EM esterleno@ugr.es
RI Pérez, Celia/IQV-7001-2023; Requena, Pilar/B-1919-2017; Arrebola,
   Juan/A-5205-2017; Salcedo Bellido, Inmaculada/L-7718-2014
OI Arrebola, Juan P./0000-0002-8643-2423; Ortega-Rico,
   Carmen/0000-0001-8432-662X; Uriz Martinez, Maialen/0000-0001-7491-0777;
   Salcedo Bellido, Inmaculada/0000-0003-4601-198X; , Ester
   Leno-Duran/0000-0001-5697-2819; Perez-Diaz, Celia/0000-0002-6550-1629
FU Instituto de Salud Carlos III [PI20/01568]; Instituto de Salud Carlos
   III, Spain [FI21/00269]
FX <STRONG>This study was supported by research grants from Instituto de
   Salud Carlos III (PI20/01568) . Celia Perez-Diaz is under contract PFIS
   (FI21/</STRONG>00269, Pre-doctoral Helath Research Training Contracts,
   Instituto de Salud Carlos III, Spain).
CR Achari AE, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18061321
   Montes JOA, 2022, INT J OBESITY, V46, P121, DOI 10.1038/s41366-021-00952-w
   Agay-Shay K, 2015, ENVIRON HEALTH PERSP, V123, P1030, DOI 10.1289/ehp.1409049
   Ahmadian M, 2013, NAT MED, V19, P557, DOI 10.1038/nm.3159
   Anderson LM, 2000, ENVIRON HEALTH PERSP, V108, P573, DOI 10.2307/3454549
   [Anonymous], 2023, Draft Proposed Approach for Cumulative Risk Assessment of High-Priority Phthalates and a Manufacturer-Requested Phthalate under the Toxic Substances Control Act
   Ashley-Martin J, 2014, ENVIRON HEALTH-GLOB, V13, DOI 10.1186/1476-069X-13-84
   Bai JJ, 2022, SCI TOTAL ENVIRON, V851, DOI 10.1016/j.scitotenv.2022.158218
   Berman YE, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph192215244
   Berman YE, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18094725
   Blaton Victor, 2007, EJIFCC, V18, P15
   Boas M, 2010, ENVIRON HEALTH PERSP, V118, P1458, DOI 10.1289/ehp.0901331
   Boberg J, 2008, TOXICOLOGY, V250, P75, DOI 10.1016/j.tox.2008.05.020
   Botton J, 2016, ENVIRON RES, V151, P601, DOI 10.1016/j.envres.2016.08.033
   Buckley JP, 2016, EPIDEMIOLOGY, V27, P449, DOI 10.1097/EDE.0000000000000436
   Buckley JP, 2016, ENVIRON HEALTH PERSP, V124, P507, DOI 10.1289/ehp.1509788
   Buser MC, 2014, INT J HYG ENVIR HEAL, V217, P687, DOI 10.1016/j.ijheh.2014.02.005
   Carlsson A, 2018, ENDOCR CONNECT, V7, P232, DOI 10.1530/EC-17-0344
   Chang CH, 2020, SCI TOTAL ENVIRON, V737, DOI 10.1016/j.scitotenv.2020.139833
   Chen SY, 2017, ENVIRON POLLUT, V225, P112, DOI 10.1016/j.envpol.2017.03.037
   Cho YJ, 2015, MOL CELL ENDOCRINOL, V407, P9, DOI 10.1016/j.mce.2015.03.003
   Commison T.E., 2018, COMMISSION REGULATION (EU) 2018/2005 - of 17 December 2018 - Amending Annex XVII to Regulation (EC) No 1907/2006 of the European Parliament and of the Council Concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) a
   Dales RE, 2018, SCI TOTAL ENVIRON, V612, P1287, DOI 10.1016/j.scitotenv.2017.09.009
   Deierlein AL, 2016, EPIDEMIOLOGY, V27, P492, DOI 10.1097/EDE.0000000000000489
   Desvergne B, 2009, MOL CELL ENDOCRINOL, V304, P43, DOI 10.1016/j.mce.2009.02.017
   Ding S, 2021, ENVIRON POLLUT, V286, DOI 10.1016/j.envpol.2021.117570
   Esposito RC, 2018, DIABETES METAB SYNDR, V11, P401, DOI 10.2147/DMSO.S168430
   Etzel TM, 2023, INT J HYG ENVIR HEAL, V248, DOI 10.1016/j.ijheh.2022.114102
   Etzel TM, 2022, ENVIRON RES, V212, DOI 10.1016/j.envres.2022.113320
   European Commission, 2016, Off. J. Eur. Union, P48
   Faienza MF, 2010, PEDIATR RES, V67, P340, DOI 10.1203/PDR.0b013e3181d22757
   Fan Y, 2020, J HAZARD MATER, V385, DOI 10.1016/j.jhazmat.2019.121534
   Feige JN, 2010, ENVIRON HEALTH PERSP, V118, P234, DOI 10.1289/ehp.0901217
   Ferguson KK, 2022, ENVIRON HEALTH PERSP, V130, DOI 10.1289/EHP10077
   Ferguson KK, 2014, ENVIRON SCI TECHNOL, V48, P7018, DOI 10.1021/es502076j
   Ferguson KK, 2011, ENVIRON RES, V111, P718, DOI 10.1016/j.envres.2011.02.002
   Frederiksen H, 2007, MOL NUTR FOOD RES, V51, P899, DOI 10.1002/mnfr.200600243
   Frederiksen H, 2020, INT J HYG ENVIR HEAL, V223, P93, DOI 10.1016/j.ijheh.2019.10.002
   Gallardo-Alfaro L, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041013
   Gao H, 2023, ECOTOX ENVIRON SAFE, V262, DOI 10.1016/j.ecoenv.2023.115157
   Gao H, 2022, ECOTOX ENVIRON SAFE, V232, DOI 10.1016/j.ecoenv.2022.113247
   Gao H, 2021, ENVIRON SCI POLLUT R, V28, P55967, DOI 10.1007/s11356-021-16252-9
   Golestanzadeh M, 2019, ENVIRON SCI POLLUT R, V26, P35670, DOI 10.1007/s11356-019-06589-7
   Grindler NM, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-24505-w
   Güil-Oumrait N, 2022, ENVIRON INT, V169, DOI 10.1016/j.envint.2022.107527
   Han H, 2019, SCI TOTAL ENVIRON, V662, P714, DOI 10.1016/j.scitotenv.2019.01.151
   Harley KG, 2017, PEDIATR RES, V82, P405, DOI 10.1038/pr.2017.112
   Hashemi M, 2021, J ENVIRON PUBLIC HEA, V2021, DOI 10.1155/2021/5514073
   Heggeseth BC, 2019, ENVIRON RES, V175, P22, DOI 10.1016/j.envres.2019.04.036
   Heindel JJ, 2022, BIOCHEM PHARMACOL, V199, DOI 10.1016/j.bcp.2022.115015
   Huang H. Bin, 2022, Environ. Heal. A Glob. Access Sci. Source, V21
   Huang HB, 2022, ENVIRON HEALTH-GLOB, V21, DOI 10.1186/s12940-022-00873-9
   Huang HB, 2021, ENVIRON POLLUT, V278, DOI 10.1016/j.envpol.2021.116799
   Huang TY, 2014, ENVIRON HEALTH-GLOB, V13, DOI 10.1186/1476-069X-13-6
   Hurst CH, 2003, TOXICOL SCI, V74, P297, DOI 10.1093/toxsci/kfg145
   Institute J.B., 2017, Crit. Apprais. tools, V6
   Iseki K, 2020, INTERNAL MED, V59, P2671, DOI 10.2169/internalmedicine.4975-20
   Jeong JY, 2011, SAF HEALTH WORK, V2, P57, DOI 10.5491/SHAW.2011.2.1.57
   Jia XF, 2015, ENVIRON HEALTH PREV, V20, P168, DOI 10.1007/s12199-014-0440-4
   Jia YY, 2016, INT J ENV RES PUB HE, V13, DOI 10.3390/ijerph13111085
   Kabir ER, 2015, ENVIRON TOXICOL PHAR, V40, P241, DOI 10.1016/j.etap.2015.06.009
   Kasahara E, 2002, BIOCHEM J, V365, P849, DOI 10.1042/BJ20020254
   Kataria A, 2017, PEDIATR RES, V81, P857, DOI 10.1038/pr.2017.16
   Kim JH, 2016, J EPIDEMIOL COMMUN H, V70, P466, DOI 10.1136/jech-2015-206315
   Kim JH, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071392
   Kupsco A, 2021, ENVIRON RES, V192, DOI 10.1016/j.envres.2020.110341
   Lain KY, 2007, CLIN OBSTET GYNECOL, V50, P938, DOI 10.1097/GRF.0b013e31815a5494
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   LaRocca J, 2014, ENVIRON RES, V133, P396, DOI 10.1016/j.envres.2014.04.032
   Lee DW, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-13154-9
   Lee I, 2021, ENVIRON INT, V146, DOI 10.1016/j.envint.2020.106227
   Lee I, 2019, SCI TOTAL ENVIRON, V688, P1319, DOI 10.1016/j.scitotenv.2019.06.125
   Lee KI, 2016, ARCH TOXICOL, V90, P1211, DOI 10.1007/s00204-015-1539-0
   Li H, 2019, FOOD ADDIT CONTAM B, V12, P1, DOI 10.1080/19393210.2018.1495272
   Li J., 2021, Sci. Total Environ., V777
   Lind PM, 2012, ENVIRON HEALTH-GLOB, V11, DOI 10.1186/1476-069X-11-21
   Liu M, 2023, EXPOS HEALTH, V15, P19, DOI 10.1007/s12403-022-00471-7
   Lu XL, 2018, ENVIRON SCI POLLUT R, V25, P20550, DOI 10.1007/s11356-018-2367-6
   Lv ZQ, 2016, OBESITY, V24, P368, DOI 10.1002/oby.21359
   Maresca MM, 2016, ENVIRON HEALTH PERSP, V124, P514, DOI 10.1289/ehp.1408750
   Mariana M, 2020, J CARDIOVASC DEV DIS, V7, DOI 10.3390/jcdd7030026
   Mayes J S, 2004, Obes Rev, V5, P197, DOI 10.1111/j.1467-789X.2004.00152.x
   Mérida DM, 2023, ENVIRON POLLUT, V333, DOI 10.1016/j.envpol.2023.121957
   Minatoya M, 2018, ENVIRON RES, V161, P505, DOI 10.1016/j.envres.2017.11.052
   Montazeri P, 2022, INT J HYG ENVIR HEAL, V240, DOI 10.1016/j.ijheh.2021.113909
   Nakaviroj E, 2022, J PEDIATR ENDOCR MET, V35, P931, DOI 10.1515/jpem-2022-0083
   Obradovic M, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.585887
   Page MJ, 2021, BMJ-BRIT MED J, V372, DOI [10.1136/bmj.n71, 10.1136/bmj.n160]
   Pasquali R, 2006, FERTIL STERIL, V85, P1319, DOI 10.1016/j.fertnstert.2005.10.054
   Peng MQ, 2023, J CLIN ENDOCR METAB, V108, P1947, DOI 10.1210/clinem/dgad033
   Perng W, 2017, ENVIRON RES, V154, P311, DOI 10.1016/j.envres.2017.01.033
   Pryor JL, 2000, ENVIRON HEALTH PERSP, V108, P491, DOI 10.2307/3454541
   Radke EG, 2019, ENVIRON INT, V132, DOI 10.1016/j.envint.2019.04.040
   Requena P, 2023, ENVIRON RES, V216, DOI 10.1016/j.envres.2022.114470
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sanders AP, 2018, PEDIATR RES, V84, P165, DOI 10.1038/s41390-018-0055-3
   Schwedler G, 2020, INT J HYG ENVIR HEAL, V225, DOI 10.1016/j.ijheh.2019.113444
   Selevan SG, 2000, ENVIRON HEALTH PERSP, V108, P451, DOI 10.2307/3454536
   Shen OX, 2009, TOXICOL LETT, V191, P9, DOI 10.1016/j.toxlet.2009.07.019
   Shi TH, 2020, PREV CHRONIC DIS, V17, DOI 10.5888/pcd17.200020
   Shoaff J, 2017, ENVIRON HEALTH PERSP, V125, DOI 10.1289/EHP1022
   Silva CCV, 2021, OBESITY, V29, P409, DOI 10.1002/oby.23082
   Sol CM, 2020, INT J OBESITY, V44, P2225, DOI 10.1038/s41366-020-00672-7
   Sol CM, 2020, ENVIRON INT, V144, DOI 10.1016/j.envint.2020.106063
   Sol CM, 2020, ENVIRON INT, V138, DOI 10.1016/j.envint.2020.105677
   Stahlhut RW, 2007, ENVIRON HEALTH PERSP, V115, P876, DOI 10.1289/ehp.9882
   Stojanoska MM, 2015, ENVIRON MONIT ASSESS, V187, DOI 10.1007/s10661-015-4754-5
   Sven Erik J., 2008, Ecotoxicol. Phthalates, P2733
   Svensson K, 2011, ENVIRON RES, V111, P792, DOI 10.1016/j.envres.2011.05.015
   Takeuchi S, 2005, TOXICOLOGY, V210, P223, DOI 10.1016/j.tox.2005.02.002
   Teitelbaum SL, 2012, ENVIRON RES, V112, P186, DOI 10.1016/j.envres.2011.12.006
   Trasande L, 2013, PEDIATRICS, V132, pE646, DOI 10.1542/peds.2012-4022
   Vafeiadi M, 2018, FRONT PUBLIC HEALTH, V6, DOI 10.3389/fpubh.2018.00327
   Valvi D, 2015, ENVIRON HEALTH PERSP, V123, P1022, DOI 10.1289/ehp.1408887
   Wang Y, 2019, TOXICS, V7, DOI 10.3390/toxics7020021
   Watkins DJ, 2016, J CLIN ENDOCR METAB, V101, P78, DOI 10.1210/jc.2015-2706
   Wei STS, 2021, MSYSTEMS, V6, DOI 10.1128/mSystems.00358-21
   Wittassek M, 2008, INT J ANDROL, V31, P131, DOI 10.1111/j.1365-2605.2007.00837.x
   Wormuth M, 2006, RISK ANAL, V26, P803, DOI 10.1111/j.1539-6924.2006.00770.x
   Wu W., 2020, Int. J. Hyg Environ. Health, V228, P1
   Xie CM, 2015, MOL CELL ENDOCRINOL, V407, P67, DOI 10.1016/j.mce.2015.03.006
   Yang TC, 2017, ENVIRON RES, V156, P326, DOI 10.1016/j.envres.2017.03.038
   Yilmaz B, 2020, REV ENDOCR METAB DIS, V21, P127, DOI 10.1007/s11154-019-09521-z
   Zamora AN, 2021, FRONT PUBLIC HEALTH, V9, DOI 10.3389/fpubh.2021.620769
   Zettergren A, 2021, ENVIRON RES, V192, DOI 10.1016/j.envres.2020.110249
   Zhang H, 2022, ENVIRON RES, V204, DOI 10.1016/j.envres.2021.112109
   Zhao SG, 2021, CIRC RES, V128, P136, DOI 10.1161/CIRCRESAHA.120.314458
   Zhao Y, 2016, SCI REP-UK, V6, DOI 10.1038/srep33449
   Zhu QQ, 2020, ENVIRON POLLUT, V257, DOI 10.1016/j.envpol.2019.113509
NR 129
TC 14
Z9 15
U1 9
U2 25
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0269-7491
EI 1873-6424
J9 ENVIRON POLLUT
JI Environ. Pollut.
PD JAN 1
PY 2024
VL 340
AR 122714
DI 10.1016/j.envpol.2023.122714
EA NOV 2023
PN 1
PG 20
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA Z5VO2
UT WOS:001112750500001
PM 37844863
OA Bronze
DA 2025-06-11
ER

PT J
AU Holmannova, D
   Borsky, P
   Andrys, C
   Hamakova, K
   Cermakova, E
   Poctova, G
   Fiala, Z
   Smejkalova, J
   Blaha, V
   Borska, L
AF Holmannova, Drahomira
   Borsky, Pavel
   Andrys, Ctirad
   Hamakova, Kvetoslava
   Cermakova, Eva
   Poctova, Gabriela
   Fiala, Zdenek
   Smejkalova, Jindra
   Blaha, Vladimir
   Borska, Lenka
TI Chromosomal Aberrations and Oxidative Stress in Psoriatic Patients with
   and without Metabolic Syndrome
SO METABOLITES
LA English
DT Article
DE chromosomal aberration; psoriasis; metabolic syndrome
ID DNA-DAMAGE; CARDIOVASCULAR-DISEASE; PLAQUE PSORIASIS; RISK; CANCER; HDL;
   BIOMARKERS; REPAIR
AB Psoriasis and metabolic syndrome (MetS), a common comorbidity of psoriasis, are associated with mild chronic systemic inflammation that increases oxidative stress and causes cell and tissue damage. At the cellular level, chromosomal and DNA damage has been documented, thus confirming their genotoxic effect. The main objective of our study was to show the genotoxic potential of chronic inflammation and determine whether the presence of both pathologies increases chromosomal damage compared to psoriasis alone and to evaluate whether there are correlations between selected parameters and chromosomal aberrations in patients with psoriasis and MetS psoriasis. Clinical examination (PASI score and MetS diagnostics according to National Cholesterol Education Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults; NCE/ATPIII criteria), biochemical analysis of blood samples (fasting glucose, total cholesterol, low density and high density lipoproteins; LDL, HDL, non-HDL, and triglycerides;TAG), DNA/RNA oxidative damage, and chromosomal aberration test were performed in 41 participants (20 patients with psoriasis without MetS and 21 with MetS and psoriasis). Our results showed that patients with psoriasis without metabolic syndrome (nonMetS) and psoriasis and MetS had a higher rate of chromosomal aberrations than the healthy population for which the limit of spontaneous, natural aberration was <2%. No significant differences in the aberration rate were found between the groups. However, a higher aberration rate (higher than 10%) and four numerical aberrations were documented only in the MetS group. We found no correlations between the number of chromosomal aberrations and the parameters tested except for the correlation between aberrations and HDL levels in nonMetS patients (rho 0.44; p < 0.02). Interestingly, in the MetS group, a higher number of chromosomal aberrations was documented in non-smokers compared to smokers. Data from our current study revealed an increased number of chromosomal aberrations in patients with psoriasis and MetS compared to the healthy population, especially in psoriasis with MetS, which could increase the genotoxic effect of inflammation and the risk of genomic instability, thus increasing the risk of carcinogenesis.
C1 [Holmannova, Drahomira; Borsky, Pavel; Poctova, Gabriela; Fiala, Zdenek; Smejkalova, Jindra; Borska, Lenka] Charles Univ Prague, Fac Med Hradec Kralove, Inst Prevent Med, Hradec Kralove 50003, Czech Republic.
   [Andrys, Ctirad] Charles Univ Prague, Fac Med Hradec Kralove, Dept Clin Immunol & Allergol, Hradec Kralove 50003, Czech Republic.
   [Hamakova, Kvetoslava] Univ Hosp Hradec Kralove, Fac Med Hradec Kralove, Clin Dermal & Venereal Dis, Hradec Kralove 50005, Czech Republic.
   [Cermakova, Eva] Charles Univ Prague, Med Fac, Dept Med Biophys, Hradec Kralove 50003, Czech Republic.
   [Blaha, Vladimir] Charles Univ Prague, Med Fac, Dept Internal Med Metab Care & Gerontol 3, Hradec Kralove 50003, Czech Republic.
C3 University Hospital Hradec Kralove; Charles University Prague;
   University Hospital Hradec Kralove; Charles University Prague;
   University Hospital Hradec Kralove; Charles University Prague; Charles
   University Prague; Charles University Prague
RP Borsky, P (corresponding author), Charles Univ Prague, Fac Med Hradec Kralove, Inst Prevent Med, Hradec Kralove 50003, Czech Republic.
EM holmd9ar@lfhk.cuni.cz; borskyp@lfhk.cuni.cz; andrys@lfhk.cuni.cz;
   kveta@hamakova.cz; cermakovae@lfhk.cuni.cz; poctovag@lfhk.cuni.cz;
   fiala@lfhk.cuni.cz; smejkal@lfhk.cuni.cz; blaha@lfhk.cuni.cz;
   borka@lfhk.cuni.cz
RI Holmannova, Drahomira/G-6260-2017; Cermakova, Eva/B-1906-2017; Fiala,
   Zdeněk/E-5962-2017; Borsky, Pavel/S-6307-2016; Blaha,
   Vladimir/C-1151-2016; Borska, Lenka/S-6304-2016
OI Borsky, Pavel/0000-0001-5253-2808; Blaha, Vladimir/0000-0001-8088-9919;
   Holmannova, Drahomira/0000-0002-9865-9991; Borska,
   Lenka/0000-0002-8580-1485
FU Cooperatio Program; Charles University, Faculty of Medicine in Hradec
   Kralove, the Czech Republic [SVV-260543/2020]
FX This work was supported by the Cooperatio Program, research area HEAS
   and by Charles University, Faculty of Medicine in Hradec Kralove, the
   Czech Republic, SVV-260543/2020.
CR Abdelazeem AH, 2021, J TAIBAH UNIV SCI, V15, P928, DOI 10.1080/16583655.2021.2009680
   Anand S, 2014, ASIAN PAC J CANCER P, V15, P4571, DOI 10.7314/APJCP.2014.15.11.4571
   Armstrong A, 2022, DERMATOLOGY THER, V12, P1055, DOI 10.1007/s13555-022-00695-0
   Bankoglu EE, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-29581-6
   Bellinato F, 2022, J AM ACAD DERMATOL, V86, P86, DOI 10.1016/j.jaad.2021.07.050
   Bonomini F, 2015, AGING DIS, V6, P109, DOI 10.14336/AD.2014.0305
   Borska L, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18112238
   Borsky P, 2021, IMMUN AGEING, V18, DOI 10.1186/s12979-021-00220-5
   Capon F, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18122526
   Chehimi M, 2017, J CLIN MED, V6, DOI 10.3390/jcm6070068
   Dasouki MJ, 2011, CURR GENOMICS, V12, P190, DOI 10.2174/138920211795677930
   Dobrica EC, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11020282
   Durante M, 2013, MUTAT RES-GEN TOX EN, V756, P5, DOI 10.1016/j.mrgentox.2013.05.014
   Elisia I, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-76556-7
   Esposito K, 2012, DIABETES CARE, V35, P2402, DOI 10.2337/dc12-0336
   Farkas G, 2021, MUTAT RES-GEN TOX EN, V867, DOI 10.1016/j.mrgentox.2021.503373
   Fieres J, 2022, DNA REPAIR, V114, DOI 10.1016/j.dnarep.2022.103323
   Franzke B, 2020, MUTAT RES-REV MUTAT, V786, DOI 10.1016/j.mrrev.2020.108343
   Fuxench ZCC, 2016, JAMA DERMATOL, V152, P282, DOI 10.1001/jamadermatol.2015.4847
   Gheuca-Solovastru L, 2021, APPL SCI-BASEL, V11, DOI 10.3390/app11188366
   Giammanco A, 2021, LIFE-BASEL, V11, DOI 10.3390/life11060581
   Silva IVG, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20143458
   Gorini F, 2021, DNA REPAIR, V97, DOI 10.1016/j.dnarep.2020.103027
   Grundy SM, 2006, CURR OPIN CARDIOL, V21, P1, DOI 10.1097/01.hco.0000200416.65370.a0
   Haveric A., 2016, J HEALTH SCI, V6, P121, DOI DOI 10.17532/JHSCI.2016.368
   Holmannova D, 2020, J IMMUNOL RES, V2020, DOI 10.1155/2020/7352637
   Hovland A, 2020, SCAND CARDIOVASC J, V54, P274, DOI 10.1080/14017431.2020.1775878
   Jain AK, 2018, MUTAGENICITY: ASSAYS AND APPLICATIONS, P69, DOI 10.1016/B978-0-12-809252-1.00004-3
   Karaman A, 2008, EXP DERMATOL, V17, P524, DOI 10.1111/j.1600-0625.2007.00671.x
   Karas A, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10051133
   Kay J, 2019, DNA REPAIR, V83, DOI 10.1016/j.dnarep.2019.102673
   Kim MY, 2017, ONCOL LETT, V13, P1417, DOI 10.3892/ol.2017.5584
   Korman NJ, 2020, BRIT J DERMATOL, V182, P840, DOI 10.1111/bjd.18245
   Lakhan SE, 2011, J TRANSL MED, V9, DOI 10.1186/1479-5876-9-129
   Lebwohl M, 2018, ANN INTERN MED, V168, pITC49, DOI 10.7326/AITC201804030
   Li BB, 2020, IMMUNOL RES, V68, P296, DOI 10.1007/s12026-020-09149-1
   Lorenzo C, 2007, DIABETES CARE, V30, P8, DOI 10.2337/dc06-1414
   Malkic Salihbegovic Eldina, 2015, Med Arch, V69, P85, DOI 10.5455/medarh.2015.69.85-87
   Malkova A, 2016, BIOMED PAP, V160, P553, DOI 10.5507/bp.2016.032
   Molès JP, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0169879
   Mosca M, 2021, DERMATOLOGY THER, V11, P1497, DOI 10.1007/s13555-021-00590-0
   Nagel G, 2012, ANN HEMATOL, V91, P1519, DOI 10.1007/s00277-012-1489-z
   Namiri-Kalantari R, 2015, BIOFACTORS, V41, P153, DOI 10.1002/biof.1205
   Navab M, 2011, NAT REV CARDIOL, V8, P222, DOI 10.1038/nrcardio.2010.222
   Niazi Y, 2021, DNA REPAIR, V101, DOI 10.1016/j.dnarep.2021.103079
   Obe G, 2002, MUTAT RES-FUND MOL M, V504, P17, DOI 10.1016/S0027-5107(02)00076-3
   Ocadlikova D, 2007, ACTA HYGIENICA EPIDE
   OECD, 2016, TEST 473 IN VITR MAM, DOI [10.1787/9789264264649-en, DOI 10.1787/9789264264649-EN]
   Pujol-Canadell M, 2020, DNA REPAIR, V89, DOI 10.1016/j.dnarep.2020.102838
   Ranna D, 2014, BRATISL MED J, V115, P229, DOI 10.4149/BLL_2014_047
   Rodríguez-Jiménez P, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-93780-x
   Saitoh S, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms221810017
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Salem AA, 2022, ENVIRON RES, V204, DOI 10.1016/j.envres.2021.111923
   Salihbegovic Eldina Malkic, 2015, Mater Sociomed, V27, P15, DOI 10.5455/msm.2014.27.15-17
   de Oliveira MDSP, 2015, AN BRAS DERMATOL, V90, P9, DOI 10.1590/abd1806-4841.20153038
   Shih CM, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21030859
   Shimizu I, 2014, CELL METAB, V20, P967, DOI 10.1016/j.cmet.2014.10.008
   Tang MS, 2022, MUTAT RES-REV MUTAT, V789, DOI 10.1016/j.mrrev.2021.108409
   Tichy A, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0193412
   Trafford AM, 2019, JAMA DERMATOL, V155, P1390, DOI 10.1001/jamadermatol.2019.3056
   Usman M, 2021, INT J OBESITY, V45, P2095, DOI 10.1038/s41366-021-00879-2
   Vaengebjerg S, 2020, JAMA DERMATOL, V156, P421, DOI 10.1001/jamadermatol.2020.0024
   Vicic M, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222111574
   Yamaguchi NH, 2019, TRANSL LUNG CANCER R, V8, pS3, DOI 10.21037/tlcr.2019.03.02
NR 65
TC 2
Z9 2
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD AUG
PY 2022
VL 12
IS 8
AR 688
DI 10.3390/metabo12080688
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 4A9LB
UT WOS:000845412000001
PM 35893255
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Akgün, S
   Köken, T
   Kahraman, A
AF Akgun, Sema
   Koken, Tulay
   Kahraman, Ahmet
TI Evaluation of adiponectin and leptin levels and oxidative stress in
   bipolar disorder patients with metabolic syndrome treated by valproic
   acid
SO JOURNAL OF PSYCHOPHARMACOLOGY
LA English
DT Article
DE Bipolar disorder; valproic acid; metabolic syndrome; adipokines;
   oxidative stress
ID ADIPOSE-TISSUE; BODY-WEIGHT; EPILEPTIC CHILDREN; INSULIN-RESISTANCE;
   PLASMA LEPTIN; SERUM LEPTIN; OBESITY; PROTEIN; GAIN; OVERWEIGHT
AB Introduction: An increased risk for metabolic syndrome (MS) has been described for people with psychotic and mood disorders. The aim of this study was to determine the influence of valproic acid (VPA) treatment on adiponectin, leptin levels and oxidative stress in bipolar disorder (BD).
   Methods: Forty patients with BD receiving VPA monotherapy and 20 healthy control subjects were included in this study. BD patients were divided into two groups with and without MS as group 1 and group 2, respectively. Twenty BD patients diagnosed according to the Diagnostic and Statistical Manual for Mental Disorders (DSM IV) were assessed for MS according to the National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP III) criteria. Adiponectin, leptin, protein carbonyls, sulfhydryl (-SH) and malondialdehyde (MDA) levels were measured in 40 BD patients and 20 control subjects.
   Results: Serum adiponectin levels were significantly lower in group 1 patients than in group 2 and control subjects (p<.001). Serum leptin levels were significantly higher in group 1 patients than in group 2 and control subjects (p<.001). Serum -SH levels were significantly lower in group 2 patients than in group 1 (p<.001) and control subjects (p<.05). Serum carbonyl levels were significantly higher in group 1 and group 2 patients than in control subjects (p<.001). Serum MDA levels were significantly higher in group 1 patients than in group 2 and control subjects (p<.001).
   Conclusion: These results provide further evidence that VPA treatment for patients with BD contributed to the metabolic disturbances, such as the decreased serum adiponectin and -SH levels, as well as the increased serum leptin, MDA and carbonyl levels.
C1 [Akgun, Sema; Koken, Tulay; Kahraman, Ahmet] Afyon Kocatepe Univ, Dept Med Biochem, Fac Med, TR-03200 Afyon, Turkey.
C3 Afyon Kocatepe University
RP Kahraman, A (corresponding author), Afyon Kocatepe Univ, Dept Med Biochem, Fac Med, TR-03200 Afyon, Turkey.
EM ahmetkah@aku.edu.tr
RI Kahraman, Ahmet/JDD-5660-2023
OI Kahraman, Ahmet/0000-0003-3310-3252
FU Afyon Kocatepe University [07.Tip.13]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This study
   was supported by the Scientific Investigation Fund Project of Afyon
   Kocatepe University (07.Tip.13).
CR [Anonymous], 2004, J CLIN PSYCHIAT, DOI DOI 10.4088/PCC.v06n0205
   Antonijevic IA, 1998, J PSYCHIAT RES, V32, P403, DOI 10.1016/S0022-3956(98)00032-6
   Arita Y, 1999, BIOCHEM BIOPH RES CO, V257, P79, DOI 10.1006/bbrc.1999.0255
   Atmaca M, 2002, NEUROPSYCHOBIOLOGY, V46, P176, DOI 10.1159/000067809
   Bakos Cinnia Dora, 2004, Neuropsychopharmacol Hung, V6, P86
   BAPTISTA T, 1995, PHARMACOPSYCHIATRY, V28, P35, DOI 10.1055/s-2007-979586
   Cengiz M, 2000, PHARMACOL RES, V41, P423, DOI 10.1006/phrs.1999.0603
   Chandran M, 2003, DIABETES CARE, V26, P2442, DOI 10.2337/diacare.26.8.2442
   Combs TP, 2001, J CLIN INVEST, V108, P1875, DOI 10.1172/JCI14120
   DeFronzo RA, 2004, MED CLIN N AM, V88, P787, DOI 10.1016/j.mcna.2004.04.013
   Deuschle M, 1996, HORM METAB RES, V28, P714, DOI 10.1055/s-2007-979885
   Elmslie JL, 2000, J CLIN PSYCHIAT, V61, P179, DOI 10.4088/JCP.v61n0306
   Fernandes BS, 2016, EUR PSYCHIAT, V35, P1, DOI 10.1016/j.eurpsy.2016.02.003
   Friedman Jeffrey M., 2011, Keio Journal of Medicine, V60, P1, DOI 10.2302/kjm.60.1
   Fulop T, 2006, PATHOL BIOL, V54, P375, DOI 10.1016/j.patbio.2006.07.002
   Gajwani P, 2009, EXPERT OPIN PHARMACO, V10, P1907, DOI 10.1517/14656560903064170
   Haddad PM, 2009, EXPERT OPIN DRUG MET, V5, P539, DOI [10.1517/17425250902911455 , 10.1517/17425250902911455]
   Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2548, DOI 10.1210/jc.2004-0395
   KOSTER JF, 1986, ANN RHEUM DIS, V45, P44, DOI 10.1136/ard.45.1.44
   Kuryszko J, 2016, POL J VET SCI, V19, P441, DOI 10.1515/pjvs-2016-0056
   LEVINE RL, 1990, METHOD ENZYMOL, V186, P464
   LOUGHREY CM, 1994, Q J MED, V87, P679
   Lu JY, 2008, J BIOMED SCI, V15, P565, DOI 10.1007/s11373-008-9261-z
   MAFFEI M, 1995, NAT MED, V1, P1155, DOI 10.1038/nm1195-1155
   Mansur RB, 2016, J PSYCHIATR RES, V74, P63, DOI 10.1016/j.jpsychires.2015.12.003
   McIntyre RS, 2003, J CLIN PSYCHOPHARM, V23, P323, DOI 10.1097/01.jcp.0000085403.08426.f4
   Meier U, 2004, CLIN CHEM, V50, P1511, DOI 10.1373/clinchem.2004.032482
   Morriss Richard, 2005, J Psychopharmacol, V19, P94, DOI 10.1177/0269881105058678
   Ng F, 2008, INT J NEUROPSYCHOPH, V11, P851, DOI 10.1017/S1461145707008401
   Oral EA, 2002, NEW ENGL J MED, V346, P570, DOI 10.1056/NEJMoa012437
   Pylvänen V, 2002, EPILEPSIA, V43, P514, DOI 10.1046/j.1528-1157.2002.31501.x
   Pylvänen V, 2006, EPILEPSIA, V47, P1460, DOI 10.1111/j.1528-1167.2006.00546.x
   Sarbijani HM, 2016, DIABETES METAB SYND, V10, pS86, DOI 10.1016/j.dsx.2015.09.024
   Simiti Luminita Animarie Vida, 2016, Clujul Med, V89, P65, DOI 10.15386/cjmed-524
   Toalson Patrick, 2004, Prim Care Companion J Clin Psychiatry, V6, P152
   Valko M, 2006, CHEM-BIOL INTERACT, V160, P1, DOI 10.1016/j.cbi.2005.12.009
   Vanina Y, 2002, PSYCHIATR SERV, V53, P842, DOI 10.1176/appi.ps.53.7.842
   Verrotti A, 2002, J CHILD NEUROL, V17, P265, DOI 10.1177/088307380201700405
   Verrotti A, 2008, EPILEPSY RES, V78, P171, DOI 10.1016/j.eplepsyres.2007.11.005
   Webber J, 2003, P NUTR SOC, V62, P539, DOI 10.1079/PNS2003256
   Yang WS, 2002, OBES RES, V10, P1104, DOI 10.1038/oby.2002.150
   Yang WS, 2001, J CLIN ENDOCR METAB, V86, P3815, DOI 10.1210/jc.86.8.3815
NR 42
TC 10
Z9 11
U1 0
U2 7
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0269-8811
EI 1461-7285
J9 J PSYCHOPHARMACOL
JI J. Psychopharmacol.
PD NOV
PY 2017
VL 31
IS 11
SI SI
BP 1453
EP 1459
DI 10.1177/0269881117715608
PG 7
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA FN5BP
UT WOS:000416021800007
PM 28875764
DA 2025-06-11
ER

PT J
AU Akbaraly, TN
   Ancelin, ML
   Jaussent, I
   Ritchie, C
   Barberger-Gateau, P
   Dufouil, C
   Kivimaki, M
   Berr, C
   Ritchie, K
AF Akbaraly, Tasnime N.
   Ancelin, Marie-Laure
   Jaussent, Isabelle
   Ritchie, Craig
   Barberger-Gateau, Pascale
   Dufouil, Carole
   Kivimaki, Mika
   Berr, Claudine
   Ritchie, Karen
TI Metabolic Syndrome and Onset of Depressive Symptoms in the Elderly
   Findings from the Three-City Study
SO DIABETES CARE
LA English
DT Article
ID LATE-LIFE; HEALTH; RISK; ASSOCIATION; POPULATION; MORTALITY; DISEASE;
   GENDER; ADULTS; WOMEN
AB OBJECTIVE-Given the increasing prevalence of both metabolic syndrome (MetS) and depressive symptoms during old age, we aimed to examine prospectively the association between MetS and the onset of depressive symptoms according to different age-groups in a large, general elderly population.
   RESEARCH DESIGN AND METHODS-This was a prospective cohort study of 4,446 men and women aged 65-91 years who were free of depression or depressive symptoms at baseline (the Three-City Study, France). MetS was defined using the National Cholesterol Education Program Adult Treatment Panel III criteria. New onset of depressive symptoms (the Center for Epidemiologic Studies Depression Scale score >= 16 and use of antidepressant treatment) was assessed at 2- and 4-year follow-ups.
   RESULTS-After adjusting for a large range of potential confounders, we observed MetS to be associated with 1.73-fold (95% CI 1.02-2.95) odds for new-onset depressive symptoms in the youngest age-group (65-70 years at baseline), independently of cardiovascular diseases. No such association was seen in older age-groups.
   CONCLUSIONS-Our findings suggest that the link between MetS and depressive symptoms evidenced until now in middle-aged people can be extended to older adults but not to the oldest ones. Additional research is needed to examine if a better management of MetS prevents depressive symptoms in people aged 65-70 years. Diabetes Care 34:904-909, 2011
C1 [Akbaraly, Tasnime N.; Ancelin, Marie-Laure; Jaussent, Isabelle; Berr, Claudine; Ritchie, Karen] INSERM, U1061, F-34000 Montpellier, France.
   [Akbaraly, Tasnime N.; Ancelin, Marie-Laure; Jaussent, Isabelle; Berr, Claudine; Ritchie, Karen] Univ Montpellier I, Montpellier, France.
   [Akbaraly, Tasnime N.; Kivimaki, Mika] UCL, Dept Epidemiol & Publ Hlth, London, England.
   [Akbaraly, Tasnime N.; Berr, Claudine] Ctr Hosp Univ Montpellier, Ctr Memoire Ressource & Rech, F-34059 Montpellier, France.
   [Ritchie, Craig; Ritchie, Karen] Univ London Imperial Coll Sci Technol & Med, Fac Med, London, England.
   [Barberger-Gateau, Pascale] INSERM, U897, Bordeaux, France.
   [Barberger-Gateau, Pascale] Univ Bordeaux 2, F-33076 Bordeaux, France.
   [Dufouil, Carole] INSERM, U708, Paris, France.
   [Dufouil, Carole] Hop La Pitie Salpetriere, Paris, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Montpellier; Universite de Montpellier; University of
   London; University College London; Universite de Montpellier; CHU de
   Montpellier; Imperial College London; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Universite de Bordeaux; Universite de
   Bordeaux; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Sorbonne Universite; Assistance Publique Hopitaux Paris
   (APHP); Hopital Universitaire Pitie-Salpetriere - APHP
RP Akbaraly, TN (corresponding author), INSERM, U1061, F-34000 Montpellier, France.
EM tasnime.akbaraly@inserm.fr
RI Kivimaki, Mika/B-3607-2012; Dufouil, Carole/F-5751-2014; Berr,
   Claudine/D-5238-2014; Akbaraly, Tasnime/H-1389-2018; Ancelin,
   Marie-Laure/L-1198-2019; Ritchie, Karen/G-3571-2013
OI Jaussent, Isabelle/0000-0002-8205-7590; Kivimaki,
   Mika/0000-0002-4699-5627; Berr, Claudine/0000-0001-5254-7655; Akbaraly,
   Tasnime/0000-0002-2150-4190; Ancelin, Marie-Laure/0000-0002-1149-4320;
   Ritchie, Karen/0000-0002-0688-8982
FU Fondation pour la Recherche Medicate; Caisse Nationale Maladie des
   Travailleurs Salaries; Direction Generale de la Sante; MGEN; Institut de
   la Longevite; Conseils Regionaux d'Aquitaine et Bourgogne; Fondation de
   France; Ministry of Research Institut National de la Sante et de la
   Recherche Medicale (INSERM); Agence Nationale de la Recherche
   [ANR-2006-PNRA-005, ANR-2007-LVIE-003, ANR-2007-LVIE-004]; Bupa
   Foundation, London; Academy of Finland, Helsinki, Finland; Bupa
   Foundation, London, U.K; National Heart, Lung, and Blood Institute
   [R01-HL-036310-20A2]; National Institute on Aging [R01-AG-034454-01];
   National Institutes of Health; MRC [G0902037] Funding Source: UKRI
FX The Fondation pour la Recherche Medicate funded the preparation and
   initiation of the study. The 3C study also is supported by the Caisse
   Nationale Maladie des Travailleurs Salaries, Direction Generale de la
   Sante, MGEN, Institut de la Longevite, Conseils Regionaux d'Aquitaine et
   Bourgogne, and the Fondation de France and Ministry of Research Institut
   National de la Sante et de la Recherche Medicale (INSERM) Programme
   "Cohortes et Collections de Donnees Biologiques." Parts of this project
   were financed by a grant from the Agence Nationale de la Recherche
   (project nos. ANR-2006-PNRA-005, ANR-2007-LVIE-003, and
   ANR-2007-LVIE-004). T.N.A. is supported by the Bupa Foundation, London,
   U.K. M.K. is supported by the Academy of Finland, Helsinki, Finland; the
   Bupa Foundation, London, U.K.; and the National Heart, Lung, and Blood
   Institute (R01-HL-036310-20A2) and the National Institute on Aging
   (R01-AG-034454-01), National Institutes of Health. The 3C study is
   conducted under a partnership agreement between the
   INSERM,Victor-Segalen Bordeaux 2 University, and sanofi-aventis. The
   funders had no role in the design and conduct of the study; collection,
   management, analysis, and interpretation of the data; and preparation,
   review, or approval of the manuscript. No potential conflicts of
   interest relevant to this article were reported.
CR Akbaraly TN, 2010, J CLIN ENDOCR METAB, V95, pE327, DOI 10.1210/jc.2010-0153
   Akbaraly TN, 2009, DIABETES CARE, V32, P499, DOI 10.2337/dc08-1358
   Alexopoulos GS, 1997, ARCH GEN PSYCHIAT, V54, P915
   Almeida OP, 2009, AM J GERIAT PSYCHIAT, V17, P889, DOI 10.1097/JGP.0b013e3181b047e3
   Alperovitch A, 2003, NEUROEPIDEMIOLOGY, V22, P316, DOI 10.1159/000072920
   Ancelin ML, 2010, BIOL PSYCHIAT, V68, P125, DOI 10.1016/j.biopsych.2010.04.011
   Blazer DG, 2003, J GERONTOL A-BIOL, V58, P249
   Day Caroline, 2007, Diab Vasc Dis Res, V4, P32, DOI 10.3132/dvdr.2007.003
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Gans ROB, 2006, MED CLIN N AM, V90, P573, DOI 10.1016/j.mcna.2006.05.002
   Gil Katarzyna, 2006, Kardiol Pol, V64, P464
   Heiskanen TH, 2006, J CLIN PSYCHIAT, V67, P1422, DOI 10.4088/JCP.v67n0913
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178, DOI 10.4088/JCP.v69n0202
   Krantz DS, 2000, JAMA-J AM MED ASSOC, V283, P1800, DOI 10.1001/jama.283.14.1800
   Pulkki-Råback L, 2009, HEALTH PSYCHOL, V28, P108, DOI 10.1037/a0012646
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Räikkönen K, 2007, DIABETES CARE, V30, P872, DOI 10.2337/dc06-1857
   Ryan J, 2008, BRIT J PSYCHIAT, V192, P12, DOI 10.1192/bjp.bp.107.039164
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
NR 21
TC 48
Z9 51
U1 0
U2 10
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD APR
PY 2011
VL 34
IS 4
BP 904
EP 909
DI 10.2337/dc10-1644
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA 746DE
UT WOS:000289221800021
PM 21346185
OA Green Submitted, hybrid, Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Ahanchi, NS
   Khatami, F
   Llanaj, E
   Quezada-Pinedo, HG
   Dizdari, H
   Bano, A
   Glisic, M
   Eisenga, MF
   Vidal, PM
   Muka, T
AF Ahanchi, Noushin Sadat
   Khatami, Farnaz
   Llanaj, Erand
   Quezada-Pinedo, Hugo G.
   Dizdari, Helga
   Bano, Arjola
   Glisic, Marija
   Eisenga, Michele F.
   Vidal, Pedro-Marques
   Muka, Taulant
TI The complementary roles of iron and estrogen in menopausal differences
   in cardiometabolic outcomes
SO CLINICAL NUTRITION
LA English
DT Review
DE Iron biomarkers; Menopause; Sex; Cardiometabolic risk factors
ID CARDIOVASCULAR RISK-FACTORS; CORONARY-HEART-DISEASE; POSTMENOPAUSAL
   HORMONE-THERAPY; ENDOGENOUS SEX-HORMONES; SERUM FERRITIN;
   INSULIN-RESISTANCE; BLOOD-PRESSURE; TRANSFERRIN RECEPTOR; METABOLIC
   SYNDROME; DIABETES-MELLITUS
AB Biological hormonal changes are frequently cited as an explanatory factor of sex and menopause differences in cardiometabolic diseases (CMD) and its associated risk factors. However, iron metabolism which varies between sexes and among women of different reproductive stages could also play a role. Recent evidence suggest that iron may contribute to CMD risk by modulating oxidative stress pathways and inflammatory responses, offering insights into the mechanistic interplay between iron and CMD development. In the current review, we provide a critical appraisal of the existing evidence on sex and menopausal differences in CMD, discuss the pitfall of current estrogen hypothesis as sole explanation, and the emerging role of iron in CMD as complementary pathway. Prior to menopause, body iron stores are lower in females as compared to males, but the increase during and after menopause, is tandem with an increased CMD risk. Importantly, basic science experiments show that an increased iron status is related to the development of type 2 diabetes (T2D), and different cardiovascular diseases (CVD). While epidemiological studies have consistently reported associations between heme iron intake and some iron biomarkers such as ferritin and transferrin saturation with the risk of T2D, the evidence regarding their connection to CVD remains controversial. We delve into the factors contributing to this inconsistency, and the limitation of relying on observational evidence, as it does not necessarily imply causation. In conclusion, we provide recommendations for future studies on evaluating the potential role of iron in elucidating the sex and menopausal differences observed in CMD. (c) 2024 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
C1 [Ahanchi, Noushin Sadat; Khatami, Farnaz; Dizdari, Helga; Bano, Arjola; Glisic, Marija] Univ Bern, Inst Social & Prevent Med, Bern, Switzerland.
   [Ahanchi, Noushin Sadat; Khatami, Farnaz] Univ Bern, Grad Sch Hlth Sci, Bern, Switzerland.
   [Ahanchi, Noushin Sadat; Vidal, Pedro-Marques] Lausanne Univ Hosp, Dept Internal Med, Internal Med, Lausanne, Switzerland.
   [Ahanchi, Noushin Sadat; Vidal, Pedro-Marques] Univ Lausanne, Lausanne, Switzerland.
   [Khatami, Farnaz] Univ Tehran Med Sci, Community Med Dept, Tehran, Iran.
   [Llanaj, Erand] German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany.
   [Llanaj, Erand] German Ctr Diabet Res DZD, Munchen Neuherberg, Germany.
   [Quezada-Pinedo, Hugo G.; Bano, Arjola] Univ Bern, Bern Univ Hosp, Dept Cardiol, Bern, Switzerland.
   [Quezada-Pinedo, Hugo G.] Erasmus MC, Univ Med Ctr Rotterdam, Generat R Study Grp, Rotterdam, Netherlands.
   [Quezada-Pinedo, Hugo G.] Sophia Childrens Hosp Univ, Erasmus MC, Dept Pediat, Rotterdam, Netherlands.
   [Glisic, Marija] Swiss Parapleg Res, Nottwil, Switzerland.
   [Eisenga, Michele F.] Univ Groningen, Dept Internal Med, Div Nephrol, Groningen, Netherlands.
   [Muka, Taulant] Epistudia, Bern, Switzerland.
C3 University of Bern; University of Bern; University of Lausanne; Centre
   Hospitalier Universitaire Vaudois (CHUV); University of Lausanne; Tehran
   University of Medical Sciences; Leibniz Association; Deutsches Institut
   fur Ernahrungsforschung Potsdam-Rehbrucke (DIfE); German Center for
   Diabetes Research (DZD); University of Bern; University Hospital of
   Bern; Erasmus University Rotterdam; Erasmus MC; Erasmus University
   Rotterdam; Erasmus MC; Swiss Paraplegic Research; University of
   Groningen
RP Muka, T (corresponding author), Epistudia, Bern, Switzerland.
EM taulant.muka@epistudia.ch
RI Llanaj, Erand/B-8403-2018; Quezada Pinedo, Hugo/JCN-8939-2023;
   Marques-Vidal, Pedro/C-9449-2009
OI khatami, Farnaz/0009-0000-6247-1455; Llanaj, Erand/0000-0003-4300-0433;
   Bano, Arjola/0000-0003-0956-7145; Marques-Vidal,
   Pedro/0000-0002-4548-8500; Quezada Pinedo, Hugo
   Guillermo/0000-0002-0641-7718; Muka, Taulant/0000-0003-3235-3073
FU Swiss National Science Foun [IZLIZ3_200256]; N.S.A [2022.0415,
   2021.0899]; Swiss National Science Foundation (SNF) [IZLIZ3_200256]
   Funding Source: Swiss National Science Foundation (SNF)
FX This research was funded by the Swiss National Science Foun- dation,
   (grant no. IZLIZ3_200256) . N.S.A received funding from Swiss Government
   Excellence Scholarship (grant agreement No 2021.0899) . H.G.Q.P received
   funding from Swiss Government Excellence Scholarship (grant agreement No
   2022.0415) . The fun- ders had no role in the design of the study; in
   the collection, ana- lyses, or interpretation of data; in the writing of
   the manuscript; or in the decision to publish the results. All authors
   declare no specific funding for this contribution.
CR Ambikairajah A, 2019, AM J OBSTET GYNECOL, V221, P393, DOI 10.1016/j.ajog.2019.04.023
   Anagnostis P, 2020, MATURITAS, V135, P74, DOI 10.1016/j.maturitas.2020.03.006
   Anand IS, 2018, CIRCULATION, V138, P80, DOI 10.1161/CIRCULATIONAHA.118.030099
   Appelman Y, 2015, ATHEROSCLEROSIS, V241, P211, DOI 10.1016/j.atherosclerosis.2015.01.027
   Appiah D, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.116.003769
   Aregbesola A, 2018, DIABETES RES CLIN PR, V141, P264, DOI 10.1016/j.diabres.2018.05.012
   Backe MB, 2016, ANNU REV NUTR, V36, P241, DOI 10.1146/annurev-nutr-071715-050939
   Bao W, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-119
   Benjamin, 2017, CIRCULATION, V135, pE646, DOI 10.1161/CIR.0000000000000491
   Berkane N, 2017, ENDOCR REV, V38, P123, DOI 10.1210/er.2016-1065
   Bibbins-Domingo K, 2004, CIRCULATION, V110, P1424, DOI 10.1161/01.CIR.0000141726.01302.83
   Bolijn R, 2017, MATURITAS, V106, P57, DOI 10.1016/j.maturitas.2017.09.004
   CAMPOS H, 1988, J CLIN ENDOCR METAB, V67, P30, DOI 10.1210/jcem-67-1-30
   Carr MC, 2003, J CLIN ENDOCR METAB, V88, P2404, DOI 10.1210/jc.2003-030242
   Cho GJ, 2011, MENOPAUSE, V18, P1120, DOI 10.1097/gme.0b013e318217e172
   Choi J, 2012, J NUTR, V142, P1929, DOI 10.3945/jn.112.160358
   Christiansen MN, 2017, CIRCULATION, V135, P1214, DOI 10.1161/CIRCULATIONAHA.116.025941
   Clarkson TB, 2013, MENOPAUSE, V20, P342, DOI [10.1097/gme.0b013e3182843aad, 10.1097/GME.0b013e3182843aad]
   Coates TD, 2014, FREE RADICAL BIO MED, V72, P23, DOI 10.1016/j.freeradbiomed.2014.03.039
   Conway D, 2019, ANAEST INTENS CARE M, V20, P175, DOI 10.1016/j.mpaic.2019.01.003
   Crielaard BJ, 2017, NAT REV DRUG DISCOV, V16, P400, DOI 10.1038/nrd.2016.248
   D'Agostino RB, 2008, CIRCULATION, V117, P743, DOI 10.1161/CIRCULATIONAHA.107.699579
   da Silva JS, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms232315140
   Das De S, 2015, ATHEROSCLEROSIS, V238, P296, DOI 10.1016/j.atherosclerosis.2014.12.018
   De Domenico I, 2011, SEMIN LIVER DIS, V31, P272, DOI 10.1055/s-0031-1286058
   de Mutsert R, 2018, METAB SYNDR RELAT D, V16, P54, DOI 10.1089/met.2017.0128
   Deroo BJ, 2006, J CLIN INVEST, V116, P561, DOI 10.1172/JCI27987
   Derstine JL, 2003, AM J CLIN NUTR, V77, P56, DOI 10.1093/ajcn/77.1.56
   Díaz-López A, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113249
   Donker AE, 2021, BLOOD REV, V50, DOI 10.1016/j.blre.2021.100866
   Dubey RK, 2002, CARDIOVASC RES, V53, P688, DOI 10.1016/S0008-6363(01)00527-2
   Eftekhari MH, 2013, INT J PREVENTIVE MED, V4, P911
   El Khoudary SR, 2020, CIRCULATION, V142, pe506, DOI 10.1161/CIR.0000000000000912
   Engle-Stone R, 2013, J NUTR, V143, P369, DOI 10.3945/jn.112.167775
   Faulkner JL, 2019, BIOL SEX DIFFER, V10, DOI 10.1186/s13293-019-0246-6
   Galaris D, 2019, BBA-MOL CELL RES, V1866, DOI 10.1016/j.bbamcr.2019.118535
   Ganz T, 2011, ANNU REV MED, V62, P347, DOI 10.1146/annurev-med-050109-142444
   Gill D, 2017, ARTERIOSCL THROM VAS, V37, P1788, DOI [10.1161/ATVBAHA.117.309757, 10.1161/atvbaha.117.309757]
   Glisic M, 2018, CIRC RES, V122, P97, DOI 10.1161/CIRCRESAHA.117.311681
   Goldberg RJ, 2005, AM J MED, V118, P728, DOI 10.1016/j.amjmed.2005.04.013
   Golden SH, 2007, J CLIN ENDOCR METAB, V92, P1289, DOI 10.1210/jc.2006-1895
   Goossens GH, 2021, NAT REV ENDOCRINOL, V17, P47, DOI 10.1038/s41574-020-00431-8
   GORDON T, 1978, ANN INTERN MED, V89, P157, DOI 10.7326/0003-4819-89-2-157
   Graham FJ, 2023, EUR J HEART FAIL, V25, P528, DOI 10.1002/ejhf.2810
   Hales Craig M, 2017, NCHS Data Brief, P1
   Halle M, 1997, ATHEROSCLEROSIS, V128, P235, DOI 10.1016/S0021-9150(96)05994-1
   Harrison AV, 2023, ANNU REV PHYSIOL, V85, P339, DOI 10.1146/annurev-physiol-022522-102832
   Harvey RE, 2015, WOMENS HEALTH, V11, P239, DOI [10.2217/whe.14.64, 10.2217/WHE.14.64]
   Huth C, 2015, EUR J ENDOCRINOL, V173, P643, DOI 10.1530/EJE-15-0631
   Ikuta Katsuya, 2015, Rinsho Ketsueki, V56, P194, DOI 10.11406/rinketsu.56.194
   Jacob C, 2019, ESC HEART FAIL, V6, P840, DOI 10.1002/ehf2.12485
   Jankowska EA, 2013, EUR HEART J, V34, P827, DOI 10.1093/eurheartj/ehs377
   Jankowska EA, 2010, EUR HEART J, V31, P1872, DOI 10.1093/eurheartj/ehq158
   Jehn ML, 2007, AM J EPIDEMIOL, V165, P1047, DOI 10.1093/aje/kwk093
   Jian JL, 2009, ANTIOXID REDOX SIGN, V11, P2939, DOI [10.1089/ars.2009.2576, 10.1089/ARS.2009.2576]
   Jiang R, 2004, JAMA-J AM MED ASSOC, V291, P711, DOI 10.1001/jama.291.6.711
   Jneid H, 2008, CIRCULATION, V118, P2803, DOI 10.1161/CIRCULATIONAHA.108.789800
   Kappert K, 2012, CIRCULATION, V126, P934, DOI 10.1161/CIRCULATIONAHA.111.086660
   Karvonen-Gutierrez CA, 2016, CURR DIABETES REP, V16, DOI 10.1007/s11892-016-0714-x
   Kautzky-Willer A, 2015, DIABETES OBES METAB, V17, P533, DOI 10.1111/dom.12449
   Kautzky-Willer A, 2016, ENDOCR REV, V37, P278, DOI 10.1210/er.2015-1137
   Kilani N, 2015, NUTR METAB CARDIOVAS, V25, P1025, DOI 10.1016/j.numecd.2015.07.005
   Kodogo V, 2019, CLIN RES CARDIOL, V108, P831, DOI 10.1007/s00392-019-01441-x
   Kunutsor SK, 2013, DIABETES-METAB RES, V29, P308, DOI 10.1002/dmrr.2394
   Lapice E, 2013, CURR ATHEROSCLER REP, V15, DOI 10.1007/s11883-013-0358-0
   Leening MJG, 2014, BMJ-BRIT MED J, V349, DOI 10.1136/bmj.g5992
   Li J, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0190310
   Li SZ, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.707138
   Liu QJ, 2009, CURR MED CHEM, V16, P113, DOI 10.2174/092986709787002862
   Loncar G, 2021, ESC HEART FAIL, V8, P2368, DOI 10.1002/ehf2.13265
   Maas AHEM, 2021, EUR HEART J, V42, P967, DOI 10.1093/eurheartj/ehaa1044
   Mackenzie EL, 2008, ANTIOXID REDOX SIGN, V10, P997, DOI 10.1089/ars.2007.1893
   Fernández-Real JM, 2015, DIABETES CARE, V38, P2169, DOI 10.2337/dc14-3082
   Fernández-Real JM, 2014, LANCET DIABETES ENDO, V2, P513, DOI 10.1016/S2213-8587(13)70174-8
   Marques A, 2018, EUR J PUBLIC HEALTH, V28, P295, DOI 10.1093/eurpub/ckx143
   Martins D., 2001, J GEND SPECIF MED, V4, P10
   Mauvais-Jarvis F, 2017, ENDOCR REV, V38, P173, DOI 10.1210/er.2016-1146
   Mauvais-Jarvis F, 2017, DIABETES, V66, P568, DOI 10.2337/dbi16-0063
   Mauvais-Jarvis F, 2015, BIOL SEX DIFFER, V6, DOI 10.1186/s13293-015-0033-y
   Mauvais-Jarvis F, 2013, ENDOCR REV, V34, P309, DOI 10.1210/er.2012-1055
   Melenovsky V, 2017, EUR J HEART FAIL, V19, P522, DOI 10.1002/ejhf.640
   Mendis S, 2011, Global Atlas on Cardiovascular Disease Prevention and Control
   Merlo F, 2023, J CLIN MED, V12, DOI 10.3390/jcm12165338
   Merz A, 2016, HEART, V102, DOI 10.1136/heartjnl-2016-309849
   Mikkelsen LF, 2019, CLIN CHEM, V65, P180, DOI 10.1373/clinchem.2018.292763
   Milman N, 1996, INT J HEMATOL, V63, P103
   Montonen J, 2012, DIABETOLOGIA, V55, P2613, DOI 10.1007/s00125-012-2633-y
   Mozaffarian D, 2016, CIRCULATION, V133, P187, DOI 10.1161/CIRCULATIONAHA.115.018585
   Mu QD, 2021, SCI BULL, V66, P1806, DOI 10.1016/j.scib.2021.02.010
   Muñoz-Bravo C, 2013, NUTRIENTS, V5, P2384, DOI 10.3390/nu5072384
   Nappi RE, 2021, LANCET DIABETES ENDO, V9, P135, DOI 10.1016/S2213-8587(21)00018-8
   Narayan KMV, 2003, JAMA-J AM MED ASSOC, V290, P1884, DOI 10.1001/jama.290.14.1884
   Okonko DO, 2004, J CARD FAIL, V10, pS5, DOI 10.1016/j.cardfail.2004.01.004
   Orban E, 2014, DIABETES-METAB RES, V30, P372, DOI 10.1002/dmrr.2506
   Peters SAE, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1005-5
   Peters SAE, 2014, LANCET, V383, P1973, DOI 10.1016/S0140-6736(14)60040-4
   Piperno A, 2002, J HYPERTENS, V20, P1513, DOI 10.1097/00004872-200208000-00013
   Pitchika A, 2020, DIABETES RES CLIN PR, V163, DOI 10.1016/j.diabres.2020.108149
   Podmore C, 2016, DIABETES CARE, V39, P572, DOI 10.2337/dc15-0257
   Poon S, 2012, AM HEART J, V163, P66, DOI 10.1016/j.ahj.2011.09.025
   Punnonen K, 1997, BLOOD, V89, P1052, DOI 10.1182/blood.V89.3.1052
   Rahman A, 2019, FRONT AGING NEUROSCI, V11, DOI 10.3389/fnagi.2019.00315
   Ramakrishnan U, 2002, AM J CLIN NUTR, V76, P1256, DOI 10.1093/ajcn/76.6.1256
   Reckelhoff JF, 2018, CURR OPIN NEPHROL HY, V27, P176, DOI 10.1097/MNH.0000000000000404
   Regitz-Zagrosek V, 2016, EUR HEART J, V37, P24, DOI 10.1093/eurheartj/ehv598
   Rich-Edwards JW, 2018, ENDOCR REV, V39, P424, DOI 10.1210/er.2017-00246
   Roemhild K, 2021, TRENDS PHARMACOL SCI, V42, P640, DOI 10.1016/j.tips.2021.05.001
   Rossouw JE, 2007, JAMA-J AM MED ASSOC, V297, P1465, DOI 10.1001/jama.297.13.1465
   Sabbatini AR, 2020, BIOL SEX DIFFER, V11, DOI 10.1186/s13293-020-00306-7
   Savarese Gianluigi, 2017, Card Fail Rev, V3, P7, DOI 10.15420/cfr.2016:25:2
   Senghor A., 2012, Int. J. Biol. Med. Res, V3, P1609
   Seravalle G, 2020, HYPERTENSION, V76, P1444, DOI 10.1161/HYPERTENSIONAHA.120.15511
   Simcox JA, 2013, CELL METAB, V17, P329, DOI 10.1016/j.cmet.2013.02.007
   Srivaratharajah K, 2019, MENOPAUSE, V26, P428, DOI 10.1097/GME.0000000000001304
   Staessen JA, 1997, J HUM HYPERTENS, V11, P507, DOI 10.1038/sj.jhh.1000476
   STEVENSON JC, 1993, ATHEROSCLEROSIS, V98, P83, DOI 10.1016/0021-9150(93)90225-J
   SULLIVAN JL, 1981, LANCET, V1, P1293
   Sutton-Tyrrell K, 2005, CIRCULATION, V111, P1242, DOI 10.1161/01.CIR.0000157697.54255.CE
   Swaminathan S, 2007, DIABETES CARE, V30, P1926, DOI 10.2337/dc06-2625
   Thomas MC, 2004, DIABETIC MED, V21, P798, DOI 10.1111/j.1464-5491.2004.01196.x
   Thurnham D.I., 2010, WHO. Report: priorities in the assessment of vitamin A and iron status in populations, Panama City, P15
   Torng PL, 2002, ATHEROSCLEROSIS, V161, P409, DOI 10.1016/S0021-9150(01)00644-X
   Tunstall-Pedoe H, 1999, LANCET, V353, P1547, DOI 10.1016/S0140-6736(99)04021-0
   Udipi S., 2012, Oxidative Stress - Molecular Mechanisms and Biological Effects, P73
   van Dalen DH, 2022, ESC HEART FAIL, V9, P398, DOI 10.1002/ehf2.13737
   van der Wal HH, 2019, EUR HEART J, V40, P3616, DOI 10.1093/eurheartj/ehz680
   Vari IS, 2007, DIABETES CARE, V30, P1795, DOI 10.2337/dc06-2312
   von Haehling S, 2019, JACC-HEART FAIL, V7, P36, DOI 10.1016/j.jchf.2018.07.015
   von Haehling S, 2017, CLIN RES CARDIOL, V106, P436, DOI 10.1007/s00392-016-1073-y
   Waldvogel-Abramowski S, 2014, TRANSFUS MED HEMOTH, V41, P213, DOI 10.1159/000362888
   Wang L, 2012, ATHEROSCLEROSIS, V224, P228, DOI 10.1016/j.atherosclerosis.2012.07.005
   Wang XH, 2021, J CLIN ENDOCR METAB, V106, pE4641, DOI 10.1210/clinem/dgab454
   Wenger NK, 2014, AM J CARDIOL, V113, P406, DOI 10.1016/j.amjcard.2013.08.054
   Wieringa FT, 2007, BRIT J NUTR, V98, P1070, DOI 10.1017/S0007114507756945
   Williams MJA, 2002, ATHEROSCLEROSIS, V165, P179, DOI 10.1016/S0021-9150(02)00233-2
   Wlazlo N, 2013, DIABETES CARE, V36, P309, DOI 10.2337/dc12-0505
   Wu XG, 2021, THERANOSTICS, V11, P3052, DOI 10.7150/thno.54113
   Yeo TJ, 2014, EUR J HEART FAIL, V16, P1125, DOI 10.1002/ejhf.161
   Zacharski LR, 2007, JAMA-J AM MED ASSOC, V297, P603, DOI 10.1001/jama.297.6.603
   Zacharski LR, 2000, AM HEART J, V140, P98, DOI 10.1067/mhj.2000.106646
   Zhang H, 2019, BBA-MOL BASIS DIS, V1865, P1925, DOI 10.1016/j.bbadis.2018.08.030
   Zhao M, 2020, J AM HEART ASSOC, V9, DOI 10.1161/JAHA.119.014742
   Zhao ZX, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041641
   Zhou MG, 2019, LANCET, V394, P1145, DOI 10.1016/S0140-6736(19)30427-1
   Zhu YJ, 2019, NUTR METAB CARDIOVAS, V29, P830, DOI 10.1016/j.numecd.2019.04.012
NR 145
TC 2
Z9 2
U1 1
U2 2
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD MAY
PY 2024
VL 43
IS 5
BP 1136
EP 1150
DI 10.1016/j.clnu.2024.03.026
EA APR 2024
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA RK4G1
UT WOS:001227538500001
PM 38593499
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Wolters, M
   Foraita, R
   Moreno, LA
   Molnar, D
   Russo, P
   Tornaritis, M
   De Henauw, S
   Lissner, L
   Veidebaum, T
   Winter, T
   Marron, M
   Nagrani, R
AF Wolters, Maike
   Foraita, Ronja
   Moreno, Luis A.
   Molnar, Denes
   Russo, Paola
   Tornaritis, Michael
   De Henauw, Stefaan
   Lissner, Lauren
   Veidebaum, Toomas
   Winter, Theresa
   Marron, Manuela
   Nagrani, Rajini
CA IDEFICS and I Family consortia
TI Longitudinal associations between vitamin D status and biomarkers of
   inflammation in a pan-European cohort of children and adolescents
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Children cohort; Vitamin D; Inflammatory markers; CRP; Cytokines;
   Adipokines
ID SERUM 25-HYDROXYVITAMIN D; D DEFICIENCY; CARDIOMETABOLIC RISK; METABOLIC
   SYNDROME; OBESE ADOLESCENTS; OXIDATIVE STRESS; D INSUFFICIENCY;
   ADIPOSE-TISSUE; SUPPLEMENTATION; METAANALYSIS
AB PurposeTo investigate longitudinal associations between the vitamin D status and inflammatory markers in children and adolescents.MethodsChildren from eight European countries from the IDEFICS/I.Family cohort with repeated measurements were included in this study. A linear mixed-effect model was used to model the association of serum 25(OH)D as independent variable and z-scores of inflammatory markers [CRP, cytokines, adipokines, combined inflammation score] as dependent variables, where one level accounts for differences between individuals and the other for changes over age within individuals.ResultsA total of 1,582 children were included in the study. In the adjusted model, 25(OH)D levels were positively associated with adiponectin (beta = 0.11 [95% CI 0.07; 0.16]) and negatively with the inflammation score (beta = - 0.24 [95% CI - 0.40; - 0.08]) indicating that the adiponectin z-score increased by 0.11 units and the inflammation score decreased by 0.24 units per 12.5 nmol/l increase in 25(OH)D. In children with overweight or obesity, only a positive association between 25(OH)D and IP-10 was observed while in children with normal weight adiponectin was positively and the inflammation score was negatively associated. Associations of vitamin D with adiponectin and the inflammation score were stronger in girls than in boys and a positive association with TNF-alpha was observed only in girls.ConclusionOur results suggest that an increase in vitamin D concentrations may help to regulate inflammatory biomarkers. However, it seems to be no benefit of a better vitamin D status in children with overweight/obesity unless their weight is managed to achieve an improved inflammatory marker status.
C1 [Wolters, Maike; Foraita, Ronja; Marron, Manuela; Nagrani, Rajini] Leibniz Inst Prevent Res & Epidemiol BIPS, Achter str 30, D-28359 Bremen, Germany.
   [Moreno, Luis A.] Univ Zaragoza, Inst Invest Sanitaria Aragon IIS Aragon, Inst Agroalimentario Aragon IA2, GENUD Growth Exercise Nutr & Dev Res Grp, Zaragoza, Spain.
   [Moreno, Luis A.] Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBER, Madrid, Spain.
   [Molnar, Denes] Univ Pecs, Med Sch, Dept Paediat, Pecs, Hungary.
   [Russo, Paola] CNR, Inst Food Sci, Avellino, Italy.
   [Tornaritis, Michael] Res & Educ Inst Child Hlth, Strovolos, Cyprus.
   [De Henauw, Stefaan] Univ Ghent, Dept Publ Hlth & Primary Care, Ghent, Belgium.
   [Lissner, Lauren] Univ Gothenburg, Inst Med, Sahlgrenska Acad, Sch Publ Hlth & Community Med, Gothenburg, Sweden.
   [Veidebaum, Toomas] Natl Inst Hlth Dev, Tallinn, Estonia.
   [Winter, Theresa] Univ Med Greifswald, Inst Clin Chem, Greifswald, Germany.
   [Winter, Theresa] Univ Med Greifswald, Lab Med, Greifswald, Germany.
C3 Leibniz Association; Leibniz Institute for Prevention Research &
   Epidemiology (BIPS); University of Zaragoza; Instituto de Salud Carlos
   III; University of Pecs; Consiglio Nazionale delle Ricerche (CNR);
   Istituto di Scienze dell' Alimentazione (ISA-CNR); Ghent University;
   Ghent University Hospital; University of Gothenburg; National Institute
   for Health Development - Estonia; Universitat Greifswald; Greifswald
   Medical School; Universitat Greifswald; Greifswald Medical School
RP Wolters, M (corresponding author), Leibniz Inst Prevent Res & Epidemiol BIPS, Achter str 30, D-28359 Bremen, Germany.
EM wolters@leibniz-bips.de
RI Nagrani, Rajini/W-3272-2019; Molnár, Dénes/AAB-6820-2022; Moreno,
   Luis/S-1780-2019
OI Wolters, Maike/0000-0002-4943-2141; Moreno Aznar, Luis
   A./0000-0003-0454-653X; Nagrani, Rajini/0000-0002-1708-2319
FU European Commission
FX The authors wish to thank the IDEFICS/I.Family children and their
   parents for participating in the extensive examinations. Additionally,
   the authors are grateful to the valuable support of school boards, head
   teachers and communities.
CR Ahrens W, 2017, INT J EPIDEMIOL, V46, P1394, DOI 10.1093/ije/dyw317
   Ahrens W, 2014, INT J OBESITY, V38, pS4, DOI 10.1038/ijo.2014.130
   Ahrens W, 2011, INT J OBESITY, V35, pS3, DOI 10.1038/ijo.2011.30
   Al-Daghri NM, 2014, PEDIATR RES, V75, P459, DOI 10.1038/pr.2013.229
   Amer M, 2012, AM J CARDIOL, V109, P226, DOI 10.1016/j.amjcard.2011.08.032
   Arvidsson L, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4920-5
   Asghar A, 2017, CELL IMMUNOL, V315, P18, DOI 10.1016/j.cellimm.2017.03.001
   Belenchia AM, 2013, AM J CLIN NUTR, V97, P774, DOI 10.3945/ajcn.112.050013
   Blondon M, 2016, J CLIN ENDOCR METAB, V101, P2348, DOI 10.1210/jc.2016-1368
   Börnhorst C, 2019, INT J EPIDEMIOL, V48, P1673, DOI 10.1093/ije/dyz097
   Boucher-Berry C, 2012, J BONE MINER RES, V27, P283, DOI 10.1002/jbmr.550
   Brustad N, 2022, NUTRIENTS, V14, DOI 10.3390/nu14010015
   Calton EK, 2017, EUR J CLIN NUTR, V71, P931, DOI 10.1038/ejcn.2017.67
   Calton EK, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0141770
   Charoenngam N, 2020, NUTRIENTS, V12, DOI 10.3390/nu12072097
   Codoñer-Franch P, 2012, J PEDIATR-US, V161, P848, DOI 10.1016/j.jpeds.2012.04.046
   Cole TJ, 2012, PEDIATR OBES, V7, P284, DOI 10.1111/j.2047-6310.2012.00064.x
   Dinca M, 2016, PHARMACOL RES, V107, P360, DOI 10.1016/j.phrs.2016.03.035
   Filgueiras MS, 2020, CRIT REV FOOD SCI, V60, P660, DOI 10.1080/10408398.2018.1546671
   Ganji V, 2011, AM J CLIN NUTR, V94, P225, DOI 10.3945/ajcn.111.013516
   Glatt DU, 2022, NUTRIENTS, V14, DOI 10.3390/nu14040804
   González-Gross M, 2012, BRIT J NUTR, V107, P755, DOI 10.1017/S0007114511003527
   Grant RW, 2015, OBESITY, V23, P512, DOI 10.1002/oby.21003
   Guri AJ, 2011, OBESITY, V19, P689, DOI 10.1038/oby.2010.230
   Harel Z, 2013, J ADOLESCENT HEALTH, V52, P801, DOI 10.1016/j.jadohealth.2013.03.022
   Hedeker D., 2004, SAGE HDB QUANTITATIV, P215
   Holick MF, 2007, NEW ENGL J MED, V357, P266, DOI 10.1056/NEJMra070553
   Holick Michael F, 2011, J Clin Endocrinol Metab, V96, P1911, DOI 10.1210/jc.2011-0385
   Hyppönen E, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010801
   Kollias A, 2012, EUR J PUBLIC HEALTH, V22, P389, DOI 10.1093/eurpub/ckr082
   Komolmit P, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0174608
   Koskinen J, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.117.005632
   Kuo YT, 2010, J FOOD SCI, V75, pH200, DOI 10.1111/j.1750-3841.2010.01704.x
   Lawlor DA, 2010, BMJ-BRIT MED J, V341, DOI 10.1136/bmj.c6224
   Liang YJ, 2011, BIOMED ENVIRON SCI, V24, P459, DOI 10.3967/0895-3988.2011.05.002
   Meier CA, 2003, CYTOKINE, V21, P43, DOI 10.1016/S1043-4666(02)00491-X
   Nikooyeh B, 2021, J STEROID BIOCHEM, V212, DOI 10.1016/j.jsbmb.2021.105925
   Nimitphong H, 2021, OBESITY, V29, P562, DOI 10.1002/oby.23109
   Ochiai H, 2014, BMC PEDIATR, V14, DOI 10.1186/1471-2431-14-81
   Ojaimi S, 2013, J TRANSL MED, V11, DOI 10.1186/1479-5876-11-176
   Palaniswamy S, 2020, AM J CLIN NUTR, V111, P1036, DOI 10.1093/ajcn/nqaa056
   Petersen RA, 2015, BRIT J NUTR, V114, P1647, DOI 10.1017/S0007114515003372
   Rafiq R, 2020, CYTOKINE, V131, DOI 10.1016/j.cyto.2020.155104
   Reynolds S, 2019, SOFTWARE COMPONENT V
   Riso EM, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0218901
   Rodríguez-Rodríguez E, 2014, INT J VITAM NUTR RES, V84, P98, DOI 10.1024/0300-9831/a000197
   Roth CL, 2011, J OBES, V2011, DOI 10.1155/2011/495101
   Sacheck J, 2011, J PEDIATR-US, V159, P945, DOI 10.1016/j.jpeds.2011.06.001
   Schipper HS, 2012, DIABETOLOGIA, V55, P2800, DOI 10.1007/s00125-012-2641-y
   Scolletta S, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/876319
   Shah S, 2015, J ADOLESCENT HEALTH, V57, P19, DOI 10.1016/j.jadohealth.2015.02.006
   Sina E, 2021, FOODS, V10, DOI 10.3390/foods10020377
   SMITH GT, 1995, J STUD ALCOHOL, V56, P383, DOI 10.15288/jsa.1995.56.383
   Sparrenberger K, 2018, CLIN CHIM ACTA, V479, P126, DOI 10.1016/j.cca.2018.01.017
   Sprengeler O, 2017, INT J ENV RES PUB HE, V14, DOI 10.3390/ijerph14030242
   Tepper S, 2014, NUTR METAB CARDIOVAS, V24, P489, DOI 10.1016/j.numecd.2013.10.025
   Thumann BF, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0235049
   Torun E, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/631845
   UNESCO UIS, 2012, International standard classification of education ISCED 2011
   Verbestel V, 2015, PUBLIC HEALTH NUTR, V18, P860, DOI 10.1017/S136898001400086X
   Walker GE, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0083685
   Winter T., 2020, Open J Bioresour, V7, P1, DOI [10.5334/ojb.64, DOI 10.5334/OJB.64]
   Zhang HQ, 2014, NUTRITION, V30, P1040, DOI 10.1016/j.nut.2014.02.024
NR 63
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD DEC
PY 2024
VL 63
IS 8
BP 3047
EP 3060
DI 10.1007/s00394-024-03488-7
EA SEP 2024
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA K7E7Q
UT WOS:001306260300006
PM 39231874
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Powell-Wiley, TM
   Poirier, P
   Burke, LE
   Després, JP
   Gordon-Larsen, P
   Lavie, CJ
   Lear, SA
   Ndumele, CE
   Neeland, IJ
   Sanders, P
   St-Onge, MP
AF Powell-Wiley, Tiffany M.
   Poirier, Paul
   Burke, Lora E.
   Despres, Jean-Pierre
   Gordon-Larsen, Penny
   Lavie, Carl J.
   Lear, Scott A.
   Ndumele, Chiadi E.
   Neeland, Ian J.
   Sanders, Prashanthan
   St-Onge, Marie-Pierre
CA Amer Heart Assoc Council Lifestyle
   Council Cardiovasc Stroke Nursing
   Council Clin Cardiology
   Council Epidemiology
   Stroke Council
TI Obesity and Cardiovascular Disease: A Scientific Statement From the
   American Heart Association
SO CIRCULATION
LA English
DT Review
DE AHA Scientific Statements; atrial fibrillation; cardiovascular diseases;
   coronary artery disease; death; sudden; heart; heart failure; obesity
ID BODY-MASS INDEX; PERCUTANEOUS CORONARY INTERVENTION; EPICARDIAL
   ADIPOSE-TISSUE; SUDDEN CARDIAC DEATH; INDUCED WEIGHT-LOSS; DOBUTAMINE
   STRESS ECHOCARDIOGRAPHY; ALL-CAUSE MORTALITY; ATRIAL-FIBRILLATION
   PREVALENCE; METABOLICALLY-HEALTHY OBESITY; CARDIOMETABOLIC RISK PROFILE
AB The global obesity epidemic is well established, with increases in obesity prevalence for most countries since the 1980s. Obesity contributes directly to incident cardiovascular risk factors, including dyslipidemia, type 2 diabetes, hypertension, and sleep disorders. Obesity also leads to the development of cardiovascular disease and cardiovascular disease mortality independently of other cardiovascular risk factors. More recent data highlight abdominal obesity, as determined by waist circumference, as a cardiovascular disease risk marker that is independent of body mass index. There have also been significant advances in imaging modalities for characterizing body composition, including visceral adiposity. Studies that quantify fat depots, including ectopic fat, support excess visceral adiposity as an independent indicator of poor cardiovascular outcomes. Lifestyle modification and subsequent weight loss improve both metabolic syndrome and associated systemic inflammation and endothelial dysfunction. However, clinical trials of medical weight loss have not demonstrated a reduction in coronary artery disease rates. In contrast, prospective studies comparing patients undergoing bariatric surgery with nonsurgical patients with obesity have shown reduced coronary artery disease risk with surgery. In this statement, we summarize the impact of obesity on the diagnosis, clinical management, and outcomes of atherosclerotic cardiovascular disease, heart failure, and arrhythmias, especially sudden cardiac death and atrial fibrillation. In particular, we examine the influence of obesity on noninvasive and invasive diagnostic procedures for coronary artery disease. Moreover, we review the impact of obesity on cardiac function and outcomes related to heart failure with reduced and preserved ejection fraction. Finally, we describe the effects of lifestyle and surgical weight loss interventions on outcomes related to coronary artery disease, heart failure, and atrial fibrillation.
C1 [Powell-Wiley, Tiffany M.] NIH, Bldg 10, Bethesda, MD 20892 USA.
   [Poirier, Paul] Univ Laval, Fac Pharm, Inst Univ Cardiol & Pneumol Quebec, Quebec City, PQ, Canada.
   [Burke, Lora E.] Univ Pittsburgh, Pittsburgh, PA 15260 USA.
   [Despres, Jean-Pierre] Univ Laval, VITAM Ctr Rech Sante Durable, Quebec City, PQ, Canada.
   [Gordon-Larsen, Penny] Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27515 USA.
   [Lavie, Carl J.] Ochsner Med Ctr, New Orleans, LA USA.
   [Lear, Scott A.] Simon Fraser Univ, St Pauls Hosp Canada, Burnaby, BC, Canada.
   [Ndumele, Chiadi E.] Johns Hopkins Univ, Baltimore, MD 21218 USA.
   [Neeland, Ian J.] Univ Hosp Cleveland, Med Ctr, Cleveland, OH 44106 USA.
   [Neeland, Ian J.] Case Western Reserve Univ, Sch Med, Cleveland, OH 44106 USA.
   [Sanders, Prashanthan] Univ Adelaide, Adelaide, SA, Australia.
   [Sanders, Prashanthan] Royal Adelaide Hosp, Adelaide, SA, Australia.
   [St-Onge, Marie-Pierre] Columbia Univ, Irving Med Ctr, New York, NY 10027 USA.
C3 National Institutes of Health (NIH) - USA; Laval University; Laval
   University Hospital; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh; Laval University;
   University of North Carolina; University of North Carolina Chapel Hill;
   Ochsner Health System; Simon Fraser University; Johns Hopkins
   University; University System of Ohio; Case Western Reserve University;
   Case Western Reserve University Hospital; University Hospitals of
   Cleveland; University System of Ohio; Case Western Reserve University;
   University of Adelaide; Royal Adelaide Hospital; NewYork-Presbyterian
   Hospital; Columbia University
RP Powell-Wiley, TM (corresponding author), NIH, Bldg 10, Bethesda, MD 20892 USA.
EM tiffany.powell@nih.gov
RI Poirier, Paul/KFS-2253-2024; PowellWiley, Tiffany/MCY-2981-2025;
   St-Onge, Marie-Pierre/AAB-3523-2020; Lavie, Carl/A-6014-2011; Sanders,
   Prashanthan/D-7641-2013
CR Abed HS, 2013, JAMA-J AM MED ASSOC, V310, P2050, DOI 10.1001/jama.2013.280521
   Abed HS, 2013, HEART RHYTHM, V10, P90, DOI 10.1016/j.hrthm.2012.08.043
   Abraham TM, 2015, CIRCULATION, V132, P1639, DOI 10.1161/CIRCULATIONAHA.114.015000
   Adabag S, 2015, HEART, V101, P215, DOI 10.1136/heartjnl-2014-306238
   Adachi H, 1997, DIABETES CARE, V20, P1688, DOI 10.2337/diacare.20.11.1688
   Adiels M, 2008, ARTERIOSCL THROM VAS, V28, P1225, DOI 10.1161/ATVBAHA.107.160192
   Afshin A, 2017, NEW ENGL J MED, V377, P13, DOI 10.1056/NEJMoa1614362
   Akilli H, 2014, ECHOCARDIOGR-J CARD, V31, P411, DOI 10.1111/echo.12392
   Al Chekakie MO, 2010, J AM COLL CARDIOL, V56, P784, DOI 10.1016/j.jacc.2010.03.071
   Al-Mosawi AA, 2018, J ELECTROCARDIOL, V51, P569, DOI 10.1016/j.jelectrocard.2018.03.008
   Al-Talabany S, 2018, BMC CARDIOVASC DISOR, V18, DOI 10.1186/s12872-018-0770-z
   Alpert MA, 2014, TRANSL RES, V164, P345, DOI 10.1016/j.trsl.2014.04.010
   Argulian E, 2013, J AM SOC ECHOCARDIOG, V26, P72, DOI 10.1016/j.echo.2012.09.012
   Ashwell M, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2015-010159
   Aune D, 2018, EUR J EPIDEMIOL, V33, P711, DOI 10.1007/s10654-017-0353-9
   Bajaj NS, 2018, J AM COLL CARDIOL, V72, P707, DOI 10.1016/j.jacc.2018.05.049
   Bassi N, 2014, AM J MED, V127, DOI 10.1016/j.amjmed.2014.06.035
   Batsis JA, 2008, AM J CARDIOL, V102, P930, DOI 10.1016/j.amjcard.2008.05.040
   Batsis JA, 2013, AM J CARDIOL, V112, P1592, DOI 10.1016/j.amjcard.2013.07.014
   Beavers CJ, 2015, THROMB RES, V136, P712, DOI 10.1016/j.thromres.2015.07.015
   Beccia AL, 2020, ANN EPIDEMIOL, V45, P32, DOI 10.1016/j.annepidem.2020.03.012
   Beck-da-Silva Luis, 2005, Congest Heart Fail, V11, P118, DOI 10.1111/j.1527-5299.2005.03827.x
   Bell CN, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16050861
   Benedetto U, 2014, J THORAC CARDIOV SUR, V147, P1517, DOI 10.1016/j.jtcvs.2013.05.028
   Berenson GS, 1998, NEW ENGL J MED, V338, P1650, DOI 10.1056/NEJM199806043382302
   Bhatt DL, 2017, J AM COLL CARDIOL, V69, P603, DOI 10.1016/j.jacc.2016.11.050
   Bires AM, 2013, J NUCL MED TECHNOL, V41, P274, DOI 10.2967/jnmt.113.124727
   Birkmeyer NJO, 1998, CIRCULATION, V97, P1689, DOI 10.1161/01.CIR.97.17.1689
   Bogers RP, 2007, ARCH INTERN MED, V167, P1720, DOI 10.1001/archinte.167.16.1720
   Bohula EA, 2019, NEW ENGL J MED, V380, P100, DOI 10.1056/NEJMc1813971
   Bordeaux Bryan C, 2010, Prev Cardiol, V13, P56, DOI 10.1111/j.1751-7141.2009.00058.x
   Boudou P, 2001, INT J OBESITY, V25, P1108, DOI 10.1038/sj.ijo.0801637
   Bozkurt B, 2016, CIRCULATION, V134, pE535, DOI 10.1161/CIR.0000000000000450
   Bray GA, 2018, ENDOCR REV, V39, P79, DOI 10.1210/er.2017-00253
   Brenyo A, 2012, J CARDIOVASC ELECTR, V23, P1343, DOI 10.1111/j.1540-8167.2012.02390.x
   Brinkley TE, 2011, MED SCI SPORT EXER, V43, P808, DOI 10.1249/MSS.0b013e3181fb512d
   Britton KA, 2013, J AM COLL CARDIOL, V62, P921, DOI 10.1016/j.jacc.2013.06.027
   Brunet F, 1996, J THORAC CARDIOV SUR, V111, P1200
   Buschur ME, 2013, J AM COLL CARDIOL, V62, P685, DOI 10.1016/j.jacc.2013.06.004
   Calle EE, 1999, NEW ENGL J MED, V341, P1097, DOI 10.1056/NEJM199910073411501
   Camhi SM, 2019, INT J OBESITY, V43, P1803, DOI 10.1038/s41366-018-0197-8
   Canoy D, 2013, EUR J PREV CARDIOL, V20, P759, DOI 10.1177/2047487313492631
   Carbone S, 2020, CURR PROB CARDIOLOGY, V45, DOI 10.1016/j.cpcardiol.2019.03.006
   Cardel MI, 2020, JAMA PEDIATR, V174, P609, DOI 10.1001/jamapediatrics.2020.0085
   Chang Y, 2014, J AM COLL CARDIOL, V63, P2679, DOI 10.1016/j.jacc.2014.03.042
   Chassé M, 2016, CAN J CARDIOL, V32, P327, DOI 10.1016/j.cjca.2015.06.031
   Chen YX, 2019, JAMA CARDIOL, V4, P1230, DOI 10.1001/jamacardio.2019.3891
   Cheng VY, 2010, JACC-CARDIOVASC IMAG, V3, P352, DOI 10.1016/j.jcmg.2009.12.013
   Chi PC, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0158300
   Chiuve Stephanie E, 2015, JACC Clin Electrophysiol, V1, P520
   Chow BJW, 2014, JACC-CARDIOVASC IMAG, V7, P278, DOI 10.1016/j.jcmg.2013.12.008
   Chrysohoou C, 2017, EUR J PREV CARDIOL, V24, P1627, DOI 10.1177/2047487317726069
   Clark AL, 2012, AM J CARDIOL, V110, P77, DOI 10.1016/j.amjcard.2012.02.050
   Clark AL, 2011, J CARD FAIL, V17, P374, DOI 10.1016/j.cardfail.2011.01.009
   Cooper JHF, 2016, J OBES, V2016, DOI 10.1155/2016/2479597
   Cornier MA, 2011, CIRCULATION, V124, P1996, DOI 10.1161/CIR.0b013e318233bc6a
   Couillard C, 2005, J CLIN ENDOCR METAB, V90, P6454, DOI 10.1210/jc.2004-2438
   Coutinho T, 2013, J AM COLL CARDIOL, V61, P553, DOI 10.1016/j.jacc.2012.10.035
   Cozier YC, 2014, AM J EPIDEMIOL, V179, P875, DOI 10.1093/aje/kwu004
   Cruz P, 2011, OBESITY, V19, P2274, DOI 10.1038/oby.2011.102
   Csige I, 2018, J DIABETES RES, V2018, DOI 10.1155/2018/3407306
   Cuevas AG, 2020, OBESITY, V28, P161, DOI 10.1002/oby.22648
   De Michele M, 2002, STROKE, V33, P2923, DOI 10.1161/01.STR.0000038989.90931.BE
   Deharo P, 2014, INT J CARDIOL, V176, P1200, DOI 10.1016/j.ijcard.2014.07.228
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Després JP, 2012, CIRCULATION, V126, P1301, DOI 10.1161/CIRCULATIONAHA.111.067264
   Després JP, 2012, J CLIN ENDOCR METAB, V97, P2283, DOI 10.1210/jc.2012-2081
   Di Angelantonio E, 2016, LANCET, V388, P776, DOI 10.1016/S0140-6736(16)30175-1
   Doesch C, 2010, OBESITY, V18, P2326, DOI 10.1038/oby.2010.65
   DUFLOU J, 1995, AM HEART J, V130, P306, DOI 10.1016/0002-8703(95)90445-X
   Elagizi A, 2018, PROG CARDIOVASC DIS, V61, P142, DOI 10.1016/j.pcad.2018.07.003
   Emami A, 2018, EUR J HEART FAIL, V20, P1580, DOI 10.1002/ejhf.1304
   Empana JP, 2004, CIRCULATION, V110, P2781, DOI 10.1161/01.CIR.0000146395.64065.BA
   Engin A, 2017, ADV EXP MED BIOL, V960, P345, DOI 10.1007/978-3-319-48382-5_15
   Estruch R, 2013, NEW ENGL J MED, V368, P1279, DOI 10.1056/NEJMoa1200303
   Farb MG, 2011, J AM COLL CARDIOL, V58, P232, DOI 10.1016/j.jacc.2011.01.051
   Fernandez-del-Valle M, 2018, EUR J APPL PHYSIOL, V118, P1231, DOI 10.1007/s00421-018-3852-9
   Fisher DP, 2018, JAMA-J AM MED ASSOC, V320, P1570, DOI 10.1001/jama.2018.14619
   Flegal KM, 2016, JAMA-J AM MED ASSOC, V315, P2284, DOI 10.1001/jama.2016.6458
   Flynn KE, 2009, JAMA-J AM MED ASSOC, V301, P1451, DOI 10.1001/jama.2009.457
   Folsom AR, 1998, AM J EPIDEMIOL, V148, P1187, DOI 10.1093/oxfordjournals.aje.a009608
   Fox CS, 2007, CIRCULATION, V116, P39, DOI 10.1161/CIRCULATIONAHA.106.675355
   Fraley MA, 2005, OBES REV, V6, P275, DOI 10.1111/j.1467-789X.2005.00199.x
   Franks PW, 2016, SCIENCE, V354, P69, DOI 10.1126/science.aaf5094
   Freedman DS, 2004, INT J OBESITY, V28, P159, DOI 10.1038/sj.ijo.0802515
   Friedenreich CM, 2015, JAMA ONCOL, V1, P766, DOI 10.1001/jamaoncol.2015.2239
   Fujimoto WY, 2007, DIABETES, V56, P1680, DOI 10.2337/db07-0009
   Fuller B, 2017, AM J FOREN MED PATH, V38, P162, DOI 10.1097/PAF.0000000000000310
   Fumagalli S, 2006, AM J CARDIOL, V98, P82, DOI 10.1016/j.amjcard.2006.01.065
   Futter JE, 2011, EUR J HEART FAIL, V13, P207, DOI 10.1093/eurjhf/hfq218
   Gallagher D, 2014, DIABETES CARE, V37, P3325, DOI 10.2337/dc14-1585
   Garvey WT, 2016, ENDOCR PRACT, V22, P842, DOI 10.4158/EP161356.ESGL
   Gebreab SZ, 2018, PSYCHOSOM MED, V80, P628, DOI 10.1097/PSY.0000000000000621
   Ghosh RK, 2019, AM J CARDIOL, V124, P1790, DOI 10.1016/j.amjcard.2019.08.038
   Giannopoulou I, 2005, J CLIN ENDOCR METAB, V90, P1511, DOI 10.1210/jc.2004-1782
   Gómez-Ambrosi J, 2012, INT J OBESITY, V36, P286, DOI 10.1038/ijo.2011.100
   Gondoni LA, 2009, NUTR METAB CARDIOVAS, V19, P170, DOI 10.1016/j.numecd.2008.07.001
   Gordon-Larsen P, 2018, CIRCULATION, V137, P1543, DOI 10.1161/CIRCULATIONAHA.118.032780
   Greenland P, 2007, J AM COLL CARDIOL, V49, P378, DOI 10.1016/j.jacc.2006.10.001
   Gregg EW, 2016, LANCET DIABETES ENDO, V4, P913, DOI 10.1016/S2213-8587(16)30162-0
   Grundy SM, 2016, TRENDS CARDIOVAS MED, V26, P364, DOI 10.1016/j.tcm.2015.10.004
   Guerrero R, 2009, HEPATOLOGY, V49, P791, DOI 10.1002/hep.22726
   Gulati A, 2013, JAMA-J AM MED ASSOC, V309, P896, DOI 10.1001/jama.2013.1363
   Guthikonda S, 2008, J AM COLL CARDIOL, V52, P743, DOI 10.1016/j.jacc.2008.05.031
   Hatem SN, 2014, CARDIOVASC RES, V102, P205, DOI 10.1093/cvr/cvu045
   Heffron SP, 2020, CIRC RES, V126, P1646, DOI 10.1161/CIRCRESAHA.119.315897
   Heit JA, 2016, J THROMB THROMBOLYS, V41, P3, DOI 10.1007/s11239-015-1311-6
   Hernandez AV, 2013, ANN THORAC SURG, V96, P1104, DOI 10.1016/j.athoracsur.2013.04.029
   Herzig KH, 2014, INT J OBESITY, V38, P1089, DOI 10.1038/ijo.2013.224
   Heymsfield SB, 2016, OBES REV, V17, P262, DOI 10.1111/obr.12358
   Hibbert B, 2012, JACC-CARDIOVASC INTE, V5, P819, DOI 10.1016/j.jcin.2012.04.009
   Hintze LJ, 2018, PHYSIOL BEHAV, V189, P99, DOI 10.1016/j.physbeh.2018.03.014
   Hiuge-Shimizu A, 2012, ANN MED, V44, P82, DOI 10.3109/07853890.2010.526138
   Holroyd EW, 2017, JACC-CARDIOVASC INTE, V10, P1283, DOI 10.1016/j.jcin.2017.03.013
   Honkala SM, 2017, MED SCI SPORT EXER, V49, P1309, DOI 10.1249/MSS.0000000000001232
   Hookana E, 2011, HEART RHYTHM, V8, P1570, DOI 10.1016/j.hrthm.2011.06.031
   Horwich TB, 2018, PROG CARDIOVASC DIS, V61, P151, DOI 10.1016/j.pcad.2018.05.005
   Hruskova J, 2018, J CLIN MED, V7, DOI 10.3390/jcm7050113
   HSIEH SD, 1995, INT J OBESITY, V19, P585
   Hu G, 2010, CIRCULATION, V121, P237, DOI 10.1161/CIRCULATIONAHA.109.887893
   Hu SJ, 2007, CAN J CARDIOL, V23, P885, DOI 10.1016/S0828-282X(07)70844-9
   HUBERT HB, 1983, CIRCULATION, V67, P968, DOI 10.1161/01.CIR.67.5.968
   Husmann L, 2006, ROFO-FORTSCHR RONTG, V178, P1007, DOI 10.1055/s-2006-926871
   Huxley RR, 2011, CIRCULATION, V123, P1501, DOI [10.1161/circulationaha.110.009035, 10.1161/CIRCULATIONAHA.110.009035]
   Iacobellis G, 2003, J CLIN ENDOCR METAB, V88, P5163, DOI 10.1210/jc.2003-030698
   Iacobellis G, 2015, NAT REV ENDOCRINOL, V11, P363, DOI 10.1038/nrendo.2015.58
   Iacobellis G, 2009, OBESITY, V17, P625, DOI 10.1038/oby.2008.575
   Imai A, 2012, ATHEROSCLEROSIS, V222, P524, DOI 10.1016/j.atherosclerosis.2012.03.018
   Ishii T, 1998, J PATHOL, V185, P4, DOI 10.1002/(SICI)1096-9896(199805)185:1<4::AID-PATH50>3.0.CO;2-3
   Ishikawa Y, 1997, VIRCHOWS ARCH, V430, P163, DOI 10.1007/BF01008038
   Jain R, 2010, CIRC-CARDIOVASC QUAL, V3, P490, DOI 10.1161/CIRCOUTCOMES.109.912501
   Jastreboff AM, 2019, OBESITY, V27, P7, DOI 10.1002/oby.22378
   Jensen, 2014, CIRCULATION, V129, pS139, DOI 10.1161/CIR.0000000000000070
   Joncas SX, 2013, OBESITY, V21, P1753, DOI 10.1002/oby.20029
   Jorsal A, 2017, EUR J HEART FAIL, V19, P69, DOI 10.1002/ejhf.657
   Karason K, 2000, ARCH INTERN MED, V160, P1797, DOI 10.1001/archinte.160.12.1797
   KASPER EK, 1992, AM J CARDIOL, V70, P921, DOI 10.1016/0002-9149(92)90739-L
   Keating SE, 2015, J HEPATOL, V63, P174, DOI 10.1016/j.jhep.2015.02.022
   Kenchaiah S, 2002, NEW ENGL J MED, V347, P305, DOI 10.1056/NEJMoa020245
   Khan SS, 2018, JAMA CARDIOL, V3, P280, DOI 10.1001/jamacardio.2018.0022
   Kitzman DW, 2017, CIRCULATION, V136, P20, DOI 10.1161/CIRCULATIONAHA.117.028365
   Klein S, 2010, DIABETES CARE, V33, P1693, DOI 10.2337/dc10-0744
   Konno T, 2015, J CARDIOVASC ELECTR, V26, P1081, DOI 10.1111/jce.12742
   Korbee RS, 2013, J NUCL CARDIOL, V20, P227, DOI 10.1007/s12350-012-9657-z
   Koshino Y, 2013, OBESITY, V21, P1111, DOI 10.1002/oby.20168
   Kronmal RA, 2007, CIRCULATION, V115, P2722, DOI 10.1161/CIRCULATIONAHA.106.674143
   Labounty TM, 2013, EUR HEART J-CARD IMG, V14, P456, DOI 10.1093/ehjci/jes179
   Lalani AP, 2000, OBES RES, V8, P20, DOI 10.1038/oby.2000.4
   Lancefield T, 2010, JACC-CARDIOVASC INTE, V3, P660, DOI 10.1016/j.jcin.2010.03.018
   Larsen BA, 2015, ATHEROSCLEROSIS, V239, P470, DOI 10.1016/j.atherosclerosis.2015.02.022
   Lassale C, 2018, EUR HEART J, V39, P397, DOI 10.1093/eurheartj/ehx448
   Lau DH, 2017, CIRCULATION, V136, P583, DOI 10.1161/CIRCULATIONAHA.116.023163
   Lauridsen BK, 2018, EUR HEART J, V39, P385, DOI 10.1093/eurheartj/ehx662
   Lavie CJ, 2018, J AM COLL CARDIOL, V72, P1506, DOI 10.1016/j.jacc.2018.08.1037
   Lavie CJ, 2017, J AM COLL CARDIOL, V70, P2750, DOI 10.1016/j.jacc.2017.10.017
   Lavie CJ, 2017, J AM COLL CARDIOL, V70, P2022, DOI 10.1016/j.jacc.2017.09.002
   Lavie CJ, 2016, JACC-HEART FAIL, V4, P769, DOI 10.1016/j.jchf.2016.07.007
   Lavie CJ, 2013, MAYO CLIN PROC, V88, P251, DOI 10.1016/j.mayocp.2012.11.020
   Lear SA, 1999, SPORTS MED, V27, P285, DOI 10.2165/00007256-199927050-00002
   Lee BK, 2015, CIRCULATION, V131, P1054, DOI 10.1161/CIRCULATIONAHA.114.012636
   Lee JJ, 2018, AM J MED, V131, P684, DOI 10.1016/j.amjmed.2018.02.002
   Legault S, 2010, CARDIOVASC ULTRASOUN, V8, DOI 10.1186/1476-7120-8-30
   Lerakis S, 2007, OBES SURG, V17, P1475, DOI 10.1007/s11695-008-9425-y
   Lesser IA, 2016, MED SCI SPORT EXER, V48, P1371, DOI 10.1249/MSS.0000000000000906
   Levitan EB, 2009, CIRC-HEART FAIL, V2, P202, DOI 10.1161/CIRCHEARTFAILURE.108.794099
   Li YH, 2013, INT J CARDIOL, V168, P4315, DOI 10.1016/j.ijcard.2013.04.174
   Lien LF, 2007, HYPERTENSION, V50, P609, DOI 10.1161/HYPERTENSIONAHA.107.089458
   Lim S, 2019, OBES REV, V20, P599, DOI 10.1111/obr.12820
   Littlejohns B, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100579
   Liuzzo G, 2001, Rays, V26, P221
   Loehr LR, 2009, CIRC-HEART FAIL, V2, P18, DOI 10.1161/CIRCHEARTFAILURE.108.813782
   Loos RJF, 2012, BEST PRACT RES CL EN, V26, P211, DOI 10.1016/j.beem.2011.11.003
   Lu Y, 2014, LANCET, V383, P970, DOI 10.1016/S0140-6736(13)61836-X
   Ma CH, 2017, BMJ-BRIT MED J, V359, DOI 10.1136/bmj.j4849
   Ma WQ, 2018, OBES REV, V19, P1236, DOI 10.1111/obr.12713
   Madu EC, 2000, CHEST, V117, P657, DOI 10.1378/chest.117.3.657
   Maffetone PB, 2017, FRONT PUBLIC HEALTH, V4, DOI 10.3389/fpubh.2016.00279
   Mahabadi AA, 2009, EUR HEART J, V30, P850, DOI 10.1093/eurheartj/ehn573
   Mahajan R, 2018, JACC-CLIN ELECTROPHY, V4, P1529, DOI 10.1016/j.jacep.2018.08.014
   Mahajan R, 2015, J AM COLL CARDIOL, V66, P1, DOI 10.1016/j.jacc.2015.04.058
   Maillard F, 2016, DIABETES METAB, V42, P433, DOI 10.1016/j.diabet.2016.07.031
   MANSON JE, 1995, NEW ENGL J MED, V333, P677, DOI 10.1056/NEJM199509143331101
   Margulies KB, 2016, JAMA-J AM MED ASSOC, V316, P500, DOI 10.1001/jama.2016.10260
   Marso SP, 2016, NEW ENGL J MED, V375, P311, DOI 10.1056/NEJMoa1603827
   Martin J, 2013, CAN J CARDIOL, V29, P969, DOI 10.1016/j.cjca.2012.11.010
   McAuley PA, 2018, MAYO CLIN PROC, V93, P701, DOI 10.1016/j.mayocp.2018.01.026
   MCGILL HC, 1995, ARTERIOSCL THROM VAS, V15, P431, DOI 10.1161/01.ATV.15.4.431
   MCGILL HC, 1968, LAB INVEST, V18, P560
   McGill HC, 2002, CIRCULATION, V105, P2712, DOI 10.1161/01.CIR.0000018121.67607.CE
   McMurray JJV, 2019, NEW ENGL J MED, V381, P1995, DOI 10.1056/NEJMoa1911303
   McNulty PH, 2002, CATHETER CARDIO INTE, V56, P174, DOI 10.1002/ccd.10186
   Medical Advisory Secretariat, 2010, Ont Health Technol Assess Ser, V10, P1
   Mehta L, 2007, AM J CARDIOL, V99, P906, DOI 10.1016/j.amjcard.2006.11.038
   MESSERLI FH, 1987, ARCH INTERN MED, V147, P1725, DOI 10.1001/archinte.147.10.1725
   Middeldorp ME, 2018, EUROPACE, V20, P1929, DOI 10.1093/europace/euy117
   Mongraw-Chaffin M, 2017, J CLIN ENDOCR METAB, V102, P4173, DOI 10.1210/jc.2017-01113
   Morkedal B, 2014, J AM COLL CARDIOL, V63, P1071, DOI 10.1016/j.jacc.2013.11.035
   Motoyama S, 2015, J AM COLL CARDIOL, V66, P337, DOI 10.1016/j.jacc.2015.05.069
   Moulton MJ, 1996, CIRCULATION, V94, P87
   Mulvagh SL, 2000, J AM SOC ECHOCARDIOG, V13, P331, DOI 10.1067/mje.2000.105462
   Munger TM, 2012, J AM COLL CARDIOL, V60, P851, DOI 10.1016/j.jacc.2012.03.042
   Murase T, 2012, HYPERTENS RES, V35, P186, DOI 10.1038/hr.2011.157
   Murphy JC, 2012, J APPL PHYSIOL, V112, P79, DOI 10.1152/japplphysiol.00355.2011
   Narayanan K, 2015, J AM HEART ASSOC, V4, DOI 10.1161/JAHA.114.001654
   Nazare JA, 2015, AM J CARDIOL, V115, P307, DOI 10.1016/j.amjcard.2014.10.039
   Nazare JA, 2012, AM J CLIN NUTR, V96, P714, DOI 10.3945/ajcn.112.035758
   Ndumele CE, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.116.003921
   Ndumele CE, 2011, ARTERIOSCL THROM VAS, V31, P1927, DOI 10.1161/ATVBAHA.111.228262
   Neeland IJ, 2018, CIRCULATION, V137, P1391, DOI 10.1161/CIRCULATIONAHA.117.029617
   Neeland IJ, 2015, J AM COLL CARDIOL, V65, P2150, DOI 10.1016/j.jacc.2015.01.061
   Neeland IJ, 2013, OBESITY, V21, pE439, DOI [10.1002/oby.20135, 10.1038/oby.20135]
   Neeland IJ, 2013, CIRC-CARDIOVASC IMAG, V6, P800, DOI 10.1161/CIRCIMAGING.113.000532
   Neergaard-Petersen S, 2016, SEMIN THROMB HEMOST, V42, P234, DOI 10.1055/s-0036-1571308
   Ng SSS, 2017, RESPIROLOGY, V22, P786, DOI 10.1111/resp.12963
   Nissen SE, 2016, JAMA-J AM MED ASSOC, V315, P990, DOI 10.1001/jama.2016.1558
   Nolan HR, 2013, INT J ANGIOL, V22, P31, DOI 10.1055/s-0033-1333865
   Nomura A, 2000, AM J CARDIOL, V85, P106, DOI 10.1016/S0002-9149(99)00617-7
   Norgard NB, 2018, CLIN PHARMACOKINET, V57, P663, DOI 10.1007/s40262-017-0611-8
   Obokata M, 2017, CIRCULATION, V136, P6, DOI 10.1161/CIRCULATIONAHA.116.026807
   Ohashi N, 2010, JACC-CARDIOVASC IMAG, V3, P908, DOI 10.1016/j.jcmg.2010.06.014
   Okorodudu DO, 2010, INT J OBESITY, V34, P791, DOI 10.1038/ijo.2010.5
   Ong KL, 2015, ATHEROSCLEROSIS, V241, P664, DOI 10.1016/j.atherosclerosis.2015.06.027
   Oreopoulos A, 2008, OBESITY, V16, P442, DOI 10.1038/oby.2007.36
   Pack QR, 2013, J CARDIOPULM REHABIL, V33, P68, DOI 10.1097/HCR.0b013e31827fe7e3
   Pandey A, 2018, JACC-HEART FAIL, V6, P975, DOI 10.1016/j.jchf.2018.09.006
   Pandey A, 2018, MAYO CLIN PROC, V93, P676, DOI 10.1016/j.mayocp.2018.04.015
   Pandey A, 2017, JACC-HEART FAIL, V5, P367, DOI 10.1016/j.jchf.2016.12.021
   Pandey A, 2017, J AM COLL CARDIOL, V69, P1129, DOI 10.1016/j.jacc.2016.11.081
   Pankert M, 2014, AM J CARDIOL, V113, P54, DOI 10.1016/j.amjcard.2013.09.011
   Park DW, 2013, CIRC-CARDIOVASC INTE, V6, P146, DOI 10.1161/CIRCINTERVENTIONS.112.000062
   Park J, 2016, ENDOCRINOL METAB, V31, P559, DOI 10.3803/EnM.2016.31.4.559
   Pathak RK, 2015, J AM COLL CARDIOL, V65, P2159, DOI 10.1016/j.jacc.2015.03.002
   Pathak RK, 2015, CAN J CARDIOL, V31, DOI 10.1016/j.cjca.2014.10.027
   Pathak RK, 2014, J AM COLL CARDIOL, V64, P2222, DOI 10.1016/j.jacc.2014.09.028
   Payvar S, 2013, J AM COLL CARDIOL, V62, P692, DOI 10.1016/j.jacc.2013.05.058
   Pedersen LR, 2015, EUR J PREV CARDIOL, V22, P1009, DOI 10.1177/2047487314545280
   Piché ME, 2018, PROG CARDIOVASC DIS, V61, P103, DOI 10.1016/j.pcad.2018.06.004
   Pietrasik G, 2007, J CARDIOVASC ELECTR, V18, P181, DOI 10.1111/j.1540-8167.2006.00680.x
   Plourde B, 2014, EXPERT REV CARDIOVAS, V12, P1099, DOI 10.1586/14779072.2014.952283
   Plourde G, 2015, LANCET, V386, P2192, DOI 10.1016/S0140-6736(15)00305-0
   Poirier P, 2006, CIRCULATION, V113, P898, DOI 10.1161/CIRCULATIONAHA.106.171016
   Pouliopoulos J, 2013, CIRCULATION, V128, P2296, DOI 10.1161/CIRCULATIONAHA.113.002238
   Prabhakar G, 2002, ANN THORAC SURG, V74, P1125, DOI 10.1016/S0003-4975(02)03899-7
   Prapas SN, 2010, INTERACT CARDIOV TH, V11, P234, DOI 10.1510/icvts.2010.234443
   Quercioli A, 2013, EUR HEART J, V34, P2063, DOI 10.1093/eurheartj/eht085
   Rabkin SW, 2015, OBES REV, V16, P406, DOI 10.1111/obr.12270
   Rahmani J, 2020, THROMB RES, V192, P64, DOI 10.1016/j.thromres.2020.05.014
   Rao G, 2015, CIRCULATION, V132, P457, DOI 10.1161/CIR.0000000000000223
   Rao S, 2019, MAYO CLIN PROC, V94, P211, DOI 10.1016/j.mayocp.2018.09.019
   Reis JP, 2015, OBESITY, V23, P879, DOI 10.1002/oby.21023
   Rocha VZ, 2009, NAT REV CARDIOL, V6, P399, DOI 10.1038/nrcardio.2009.55
   Flores MR, 2017, EXPERT REV CARDIOVAS, V15, P567, DOI 10.1080/14779072.2017.1352471
   Romero-Corral A, 2008, INT J OBESITY, V32, P959, DOI 10.1038/ijo.2008.11
   Romero-Corral A, 2010, EUR HEART J, V31, P737, DOI [10.1093/eurheartj/ehn347, 10.1093/eurheartj/ehp487]
   Rosengren A, 2009, EUR HEART J, V30, P1113, DOI 10.1093/eurheartj/ehp076
   Ross R, 2004, OBES RES, V12, P789, DOI 10.1038/oby.2004.95
   Ross R, 2000, ANN INTERN MED, V133, P92, DOI 10.7326/0003-4819-133-2-200007180-00008
   Ross R, 2009, NAT REV ENDOCRINOL, V5, P319, DOI 10.1038/nrendo.2009.78
   Ruka E, 2016, EUR J CARDIO-THORAC, V50, P1188, DOI 10.1093/ejcts/ezw164
   Russo C, 2011, J AM COLL CARDIOL, V57, P1368, DOI 10.1016/j.jacc.2010.10.042
   Sabbag Avi, 2016, JACC Clin Electrophysiol, V2, P448, DOI 10.1016/j.jacep.2016.03.003
   Sahakyan KR, 2015, ANN INTERN MED, V163, P827, DOI 10.7326/M14-2525
   Sallis JF, 2009, MILBANK Q, V87, P123, DOI 10.1111/j.1468-0009.2009.00550.x
   Schindler TH, 2006, J AM COLL CARDIOL, V47, P1188, DOI 10.1016/j.jacc.2005.10.062
   Schindler TH, 2010, JACC-CARDIOVASC IMAG, V3, P623, DOI 10.1016/j.jcmg.2010.04.007
   Schnabel RB, 2015, LANCET, V386, P154, DOI 10.1016/S0140-6736(14)61774-8
   See R, 2007, J AM COLL CARDIOL, V50, P752, DOI 10.1016/j.jacc.2007.04.066
   Shah BN, 2016, ECHO RES PRACT, V3, pR13, DOI 10.1530/ERP-16-0010
   Shah RV, 2017, JACC-CARDIOVASC IMAG, V10, P1016, DOI 10.1016/j.jcmg.2016.10.024
   Shah Ravi V, 2014, JACC Cardiovasc Imaging, V7, P1221, DOI 10.1016/j.jcmg.2014.07.017
   Shah RV, 2014, JACC-CARDIOVASC IMAG, V7, P462, DOI 10.1016/j.jcmg.2013.11.011
   Shahreyar Muhammad, 2017, JACC Clin Electrophysiol, V3, P174, DOI 10.1016/j.jacep.2016.08.011
   Shimabukuro M, 2013, ARTERIOSCL THROM VAS, V33, P1077, DOI 10.1161/ATVBAHA.112.300829
   Shimada YJ, 2016, J AM COLL CARDIOL, V67, P895, DOI 10.1016/j.jacc.2015.12.016
   Sierra-Johnson J, 2008, EUR J CARDIOV PREV R, V15, P336, DOI 10.1097/HJR.0b013e3282f48348
   Sivam S, 2012, EUR RESPIR J, V40, P913, DOI 10.1183/09031936.00177011
   Sjöström L, 2012, JAMA-J AM MED ASSOC, V307, P56, DOI 10.1001/jama.2011.1914
   Slentz CA, 2011, AM J PHYSIOL-ENDOC M, V301, pE1033, DOI 10.1152/ajpendo.00291.2011
   Sommer I, 2015, BMC PUBLIC HEALTH, V15, DOI 10.1186/s12889-015-2227-y
   St-Onge MP, 2016, CIRCULATION, V134, pE367, DOI 10.1161/CIR.0000000000000444
   Stohlawetz P, 1999, THROMB HAEMOSTASIS, V81, P613
   Strong JP, 1999, JAMA-J AM MED ASSOC, V281, P727, DOI 10.1001/jama.281.8.727
   Supariwala A, 2014, ECHOCARDIOGR-J CARD, V31, P879, DOI 10.1111/echo.12481
   Tamminen M, 2003, INT J OBESITY, V27, P907, DOI 10.1038/sj.ijo.0802312
   Taqueti VR, 2018, J AM COLL CARDIOL, V72, P2625, DOI 10.1016/j.jacc.2018.09.042
   Taqueti VR, 2015, CIRCULATION, V131, P19, DOI 10.1161/CIRCULATIONAHA.114.011939
   Tatsumi Y, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2016-013831
   Tedrow UB, 2010, J AM COLL CARDIOL, V55, P2319, DOI 10.1016/j.jacc.2010.02.029
   Terada T, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.116.005335
   Thomsen M, 2014, JAMA INTERN MED, V174, P15, DOI 10.1001/jamainternmed.2013.10522
   Tilg H, 2017, NAT REV GASTRO HEPAT, V14, P32, DOI 10.1038/nrgastro.2016.147
   Totaro Pasquale, 2008, Expert Rev Cardiovasc Ther, V6, P897, DOI 10.1586/14779072.6.6.897
   Fayh APT, 2013, BRIT J NUTR, V110, P486, DOI 10.1017/S0007114512005442
   Tsang TSM, 2008, EUR HEART J, V29, P2227, DOI 10.1093/eurheartj/ehn324
   Tsujimoto T, 2017, J AM COLL CARDIOL, V70, P2739, DOI [10.1016/j.jacc.2017.09.1111, 10.1016/j.jacc.2017.09]
   Unek IT, 2010, CLIN MED RES, V8, P89, DOI 10.3121/cmr.2010.889
   van Gemert WA, 2019, BMC PUBLIC HEALTH, V19, DOI 10.1186/s12889-019-6510-1
   Ventura HO, 2018, EUR J HEART FAIL, V20, P1588, DOI 10.1002/ejhf.1314
   Verheggen RJHM, 2016, OBES REV, V17, P664, DOI 10.1111/obr.12406
   Virani SS, 2009, TEX HEART I J, V36, P540
   Wagner BD, 2007, ANN THORAC SURG, V84, P10, DOI 10.1016/j.athoracsur.2007.03.017
   WHO Consultation, 2000, WHO TECH REP SER, V894, P1
   Wilson PWF, 2008, CIRCULATION, V118, P124, DOI 10.1161/CIRCULATIONAHA.108.772962
   Wing R, 2013, NEW ENGL J MED, V369, P145, DOI 10.1056/NEJMoa1212914
   Wong Christopher X, 2015, JACC Clin Electrophysiol, V1, P139, DOI 10.1016/j.jacep.2015.04.004
   Wong CX, 2016, CIRC-ARRHYTHMIA ELEC, V9, DOI 10.1161/CIRCEP.116.004378
   Wong CX, 2012, AM J CARDIOL, V110, P1496, DOI 10.1016/j.amjcard.2012.07.011
   Wong CX, 2011, J AM COLL CARDIOL, V57, P1745, DOI 10.1016/j.jacc.2010.11.045
   Wong P, 2001, J Invasive Cardiol, V13, P623
   Wu CK, 2015, ATHEROSCLEROSIS, V241, P607, DOI 10.1016/j.atherosclerosis.2015.05.025
   Wu YK, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17124319
   Yancy CW, 2013, J AM COLL CARDIOL, V62, pE147, DOI 10.1016/j.jacc.2013.05.019
   Yoshimura E, 2014, J OBES, V2014, DOI 10.1155/2014/197216
   Zarzoso M, 2014, ACTA PHYSIOL, V211, P36, DOI 10.1111/apha.12185
   Zhang C, 2008, CIRCULATION, V117, P1658, DOI 10.1161/CIRCULATIONAHA.107.739714
   Zhang HF, 2017, J DIABETES RES, V2017, DOI 10.1155/2017/5071740
   Zhang HJ, 2017, DIABETES OBES METAB, V19, P284, DOI 10.1111/dom.12809
   Zhou BF, 2002, BIOMED ENVIRON SCI, V15, P83
   Zieske AW, 2002, PEDIATR PATHOL MOL M, V21, P213, DOI 10.1080/15227950252852104
NR 319
TC 1884
Z9 1992
U1 66
U2 621
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD MAY 25
PY 2021
VL 143
IS 21
BP E984
EP E1010
DI 10.1161/CIR.0000000000000973
PG 27
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA SH2JJ
UT WOS:000653959500003
PM 33882682
OA Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Ibero-Baraibar, I
   Perez-Cornago, A
   Ramirez, MJ
   Martínez, JA
   Zulet, MA
AF Ibero-Baraibar, Idoia
   Perez-Cornago, Aurora
   Ramirez, Maria J.
   Martinez, J. Alfredo
   Zulet, M. Angeles
TI An Increase in Plasma Homovanillic Acid with Cocoa Extract Consumption
   Is Associated with the Alleviation of Depressive Symptoms in Overweight
   or Obese Adults on an Energy Restricted Diet in a Randomized Controlled
   Trial
SO JOURNAL OF NUTRITION
LA English
DT Article; Proceedings Paper
CT 9th Meeting on Nutrition Updates at University-of-Navarra
CY MAY 15-16, 2015
CL Pamplona, SPAIN
SP Univ Navarra, Biomed Res Ctr Network Physiopathol Obes & Nutr, Natl Inst Hlth Carlos III, PREvenc Dleta MEDiterranea, Int Union Nutr Sci, Gene Nutrient Interact Knowledge Act Task Force
DE cocoa; depression; dopamine; homovanillic acid; weight loss
ID METABOLIC SYNDROME; BRAIN DOPAMINE; COGNITIVE PERFORMANCE; OXIDATIVE
   STRESS; WEIGHT CHANGE; SHORT-TERM; ANXIETY; MOOD; METAANALYSIS;
   POLYPHENOLS
AB Background: Obesity has been associated with various health disorders, including psychological alterations. Cocoa consumption and weight management may produce a beneficial effect on these problems.
   Objective: The purpose of this study was to investigate the effect of cocoa extract supplementation as part of an energy-restricted diet on psychological status and peripheral dopaminergic activity in overweight or obese middle-aged subjects.
   Methods: In a 4-wk, double-blind, randomized, placebo-controlled parallel nutritional intervention, 22 men and 25 women [mean +/- SD age: 57 +/- 5 y; body mass index (kg/m(2)): 30.6 +/- 2.3] were studied. After a 1-wk run-in period, volunteers consumed 15% energy-restricted diets; one-half of the volunteers were randomly assigned to receive ready-to-eat meals supplemented with 1.4 g cocoa extract/d (645 mg total polyphenols/d), whereas the rest of the volunteers received the same meals without cocoa supplementation. Plasma monoamines [dopamine, dopac, and homovanillic acid (HVA)], monoamine oxidase (MAO), and psychological status (anxiety and depressive symptoms) were analyzed in fasting participants at baseline and endpoint. Data were analyzed over time, and regression and correlation analyses were conducted to determine the relation between variables.
   Results: Depressive symptoms decreased in both groups after the intervention (control: -9.4%, P < 0.001; cocoa: -6.3%, P = 0.008), but anxiety symptoms did not. The increase in plasma HVA was 11.5% greater in the cocoa group than in the control group (P = 0.016), but plasma dopamine, dopac, and MAO changes did not differ between groups. A negative relation between changes in depressive symptoms and changes in plasma HVA was observed in the cocoa group (beta = -0.39, P = 0.029). Moreover, the change in plasma dopamine was positively associated with the change in methylcatechin-O-glucoronide in the cocoa-supplemented group (r = 0.69, P = 0.019).
   Conclusion: The intake of cocoa extract by participants consuming a 15% energy-restricted diet contributed to an increase in plasma HVA concentrations. This change was associated with a reduction in depressive symptoms, suggesting a potential effect of cocoa extract intake on this relation. The present results are secondary analyses of a clinical trial that was registered at www.clinicaltrials.gov as NCT01596309.
C1 [Ibero-Baraibar, Idoia; Martinez, J. Alfredo; Zulet, M. Angeles] Univ Navarra, Dept Nutr Food Sci & Physiol, E-31080 Pamplona, Spain.
   [Ibero-Baraibar, Idoia; Martinez, J. Alfredo; Zulet, M. Angeles] Univ Navarra, Ctr Nutr Res, E-31080 Pamplona, Spain.
   [Perez-Cornago, Aurora] Univ Navarra, Dept Prevent Med & Publ Hlth, E-31080 Pamplona, Spain.
   [Ramirez, Maria J.] Univ Navarra, Dept Pharmacol & Toxicol, E-31080 Pamplona, Spain.
   [Ramirez, Maria J.; Martinez, J. Alfredo; Zulet, M. Angeles] Navarra Inst Hlth Res, Pamplona, Spain.
   [Martinez, J. Alfredo; Zulet, M. Angeles] Natl Inst Hlth Carlos III, Biomed Res Ctr Network Physiopathol Obes & Nutr, Madrid, Spain.
C3 University of Navarra; University of Navarra; University of Navarra;
   University of Navarra; University of Navarra; Instituto de Salud Carlos
   III
RP Martínez, JA (corresponding author), Univ Navarra, Dept Nutr Food Sci & Physiol, E-31080 Pamplona, Spain.; Martínez, JA (corresponding author), Univ Navarra, Ctr Nutr Res, E-31080 Pamplona, Spain.; Martínez, JA (corresponding author), Navarra Inst Hlth Res, Pamplona, Spain.; Martínez, JA (corresponding author), Natl Inst Hlth Carlos III, Biomed Res Ctr Network Physiopathol Obes & Nutr, Madrid, Spain.
EM jalfmtz@unav.es
RI Ramirez, Maria Javier/H-4383-2017; Martinez Hernandez, J
   Alfredo/K-8709-2014; Perez-Cornago, Aurora/C-1097-2016; Zulet, M.
   Angeles/H-1317-2017
OI Ramirez, Maria Javier/0000-0002-3488-9579; Ibero-Baraibar,
   Idoia/0000-0003-0091-8068; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941; Perez-Cornago, Aurora/0000-0002-5652-356X;
   Zulet, M. Angeles/0000-0002-3926-0892
CR AMIN F, 1992, SCHIZOPHRENIA BULL, V18, P123, DOI 10.1093/schbul/18.1.123
   [Anonymous], REV PSIQIAT PSICOL M
   [Anonymous], INTERAM J PSYCHOL
   Arranz S, 2013, MOL NUTR FOOD RES, V57, P936, DOI 10.1002/mnfr.201200595
   Baeza I, 2009, PSYCHIAT RES, V168, P110, DOI 10.1016/j.psychres.2008.04.011
   Belmaker RH, 2008, NEW ENGL J MED, V358, P55, DOI [10.1056/NEJMra073096, 10.1038/nrdp.2016.65]
   Carlin J, 2013, OBESITY, V21, P2513, DOI 10.1002/oby.20374
   Carpéné C, 2006, METABOLISM, V55, P1397, DOI 10.1016/j.metabol.2006.06.011
   Datla KP, 2007, J AM COLL NUTR, V26, P341, DOI 10.1080/07315724.2007.10719621
   de la Iglesia R, 2013, INT J MOL SCI, V14, P6903, DOI 10.3390/ijms14046903
   de Wit L, 2010, PSYCHIAT RES, V178, P230, DOI 10.1016/j.psychres.2009.04.015
   de Wit LM, 2010, DEPRESS ANXIETY, V27, P1057, DOI 10.1002/da.20738
   Dias GP, 2012, OXID MED CELL LONGEV, V2012, DOI 10.1155/2012/541971
   Eyres SL, 2014, NUTRITION, V30, P10, DOI 10.1016/j.nut.2013.05.028
   Fernández-Fernández L, 2015, FOOD FUNCT, V6, P1251, DOI [10.1039/c5fo00052a, 10.1039/C5FO00052A]
   Fisher NDL, 2006, J CARDIOVASC PHARM, V47, pS210, DOI 10.1097/00005344-200606001-00017
   Gea A, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-192
   Goni L, 2014, NUTR REV, V72, P673, DOI 10.1111/nure.12143
   Goto M, 2006, PROG NEURO-PSYCHOPH, V30, P701, DOI 10.1016/j.pnpbp.2006.01.016
   Herbert MK, 2013, J NEUROL, V260, P3129, DOI 10.1007/s00415-013-7126-5
   Ibero-Baraibar I, 2014, NUTR METAB CARDIOVAS, V24, P416, DOI 10.1016/j.numecd.2013.09.017
   Ibero-Baraibar I, 2015, CLIN NUTR, V34, P1010, DOI 10.1016/j.clnu.2014.11.004
   Ibero-Baraibar I, 2015, MUTAGENESIS, V30, P139, DOI 10.1093/mutage/geu056
   Jackson SE, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0104552
   Khan N, 2012, NUTR METAB CARDIOVAS, V22, P1046, DOI 10.1016/j.numecd.2011.02.001
   Kim J, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0114891
   Latif R, 2013, CURR OPIN CLIN NUTR, V16, P669, DOI 10.1097/MCO.0b013e328365a235
   Lopresti AL, 2014, PROG NEURO-PSYCHOPH, V48, P102, DOI 10.1016/j.pnpbp.2013.09.017
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Lyles GA, 1996, INT J BIOCHEM CELL B, V28, P259, DOI 10.1016/1357-2725(95)00130-1
   Messaoudi M, 2008, NUTR NEUROSCI, V11, P269, DOI 10.1179/147683008X344165
   Messerli FH, 2012, NEW ENGL J MED, V367, P1562, DOI 10.1056/NEJMon1211064
   Milagro FI, 2013, MOL ASPECTS MED, V34, P782, DOI 10.1016/j.mam.2012.06.010
   Mitani H, 2006, PROG NEURO-PSYCHOPH, V30, P531, DOI 10.1016/j.pnpbp.2005.11.021
   Nehlig A, 2013, BRIT J CLIN PHARMACO, V75, P716, DOI 10.1111/j.1365-2125.2012.04378.x
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pandya CD, 2013, PROG NEURO-PSYCHOPH, V46, P214, DOI 10.1016/j.pnpbp.2012.10.017
   Pardridge WM, 2007, DRUG DISCOV TODAY, V12, P54, DOI 10.1016/j.drudis.2006.10.013
   Parker G, 2006, J AFFECT DISORDERS, V92, P149, DOI 10.1016/j.jad.2006.02.007
   Pase MP, 2013, J PSYCHOPHARMACOL, V27, P451, DOI 10.1177/0269881112473791
   Pathak L, 2013, EXPERT OPIN INV DRUG, V22, P863, DOI 10.1517/13543784.2013.794783
   Payne ME, 2012, J ACAD NUTR DIET, V112, P2022, DOI 10.1016/j.jand.2012.08.026
   Perez-Cornago A, 2015, NUTR NEUROSCI, V18, P137, DOI 10.1179/1476830514Y.0000000116
   Perez-Cornago A, 2014, PSYCHONEUROENDOCRINO, V47, P98, DOI 10.1016/j.psyneuen.2014.05.003
   Perez-Cornago A, 2014, CLIN NUTR, V33, P1061, DOI 10.1016/j.clnu.2013.11.011
   Preiss K, 2013, OBES REV, V14, P906, DOI 10.1111/obr.12052
   Reinholz J, 2008, NUTR METAB, V5, DOI 10.1186/1743-7075-5-35
   Rey-López JP, 2011, EUR J PUBLIC HEALTH, V21, P151, DOI 10.1093/eurpub/ckq035
   Rubí B, 2010, ENDOCRINOLOGY, V151, P5570, DOI 10.1210/en.2010-0745
   Sánchez-Villegas A, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-208
   Sanchez-Villegas A, 2013, BMC MED, V11, DOI [10.1186/1741-7015-11-3, 10.1186/1741-7015-11-208]
   Sathyapalan T, 2010, SEMIN FETAL NEONAT M, V15, P89, DOI 10.1016/j.siny.2009.09.002
   Scholey AB, 2010, J PSYCHOPHARMACOL, V24, P1505, DOI 10.1177/0269881109106923
   Schultz W, 2007, ANNU REV NEUROSCI, V30, P259, DOI 10.1146/annurev.neuro.28.061604.135722
   Serra A, 2009, J CHROMATOGR B, V877, P1169, DOI 10.1016/j.jchromb.2009.03.005
   Shrime MG, 2011, J NUTR, V141, P1982, DOI 10.3945/jn.111.145482
   Sokolov AN, 2013, NEUROSCI BIOBEHAV R, V37, P2445, DOI 10.1016/j.neubiorev.2013.06.013
   Stapleton Peta, 2013, ISRN Psychiatry, V2013, P573532, DOI 10.1155/2013/573532
   STERNBERG DE, 1983, LIFE SCI, V32, P2447, DOI 10.1016/0024-3205(83)90370-3
   Sumiyoshi T, 1998, NEUROPSYCHOPHARMACOL, V19, P70
   Swencionis C, 2013, HEALTH PSYCHOL, V32, P439, DOI 10.1037/a0029186
   van Mill JG, 2013, SLEEP MED, V14, P1170, DOI 10.1016/j.sleep.2013.04.016
   Vauzour D, 2008, GENES NUTR, V3, P115, DOI 10.1007/s12263-008-0091-4
   Wang GJ, 2009, J ADDICT MED, V3, P8, DOI 10.1097/ADM.0b013e31819a86f7
   Wang GJ, 2001, LANCET, V357, P354, DOI 10.1016/S0140-6736(00)03643-6
   Zumárraga M, 2011, NEUROCHEM RES, V36, P1336, DOI 10.1007/s11064-011-0448-8
NR 66
TC 26
Z9 27
U1 0
U2 19
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD APR
PY 2016
VL 146
IS 4
BP 897S
EP 904S
DI 10.3945/jn.115.222828
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics
GA DI3RA
UT WOS:000373415000029
PM 26962189
OA Bronze
DA 2025-06-11
ER

PT J
AU Onu, A
   Trofin, DM
   Tutu, A
   Onu, I
   Galaction, AI
   Sardaru, DP
   Trofin, D
   Onita, CA
   Iordan, DA
   Matei, DV
AF Onu, Ana
   Trofin, Daniela-Marilena
   Tutu, Andrei
   Onu, Ilie
   Galaction, Anca-Irina
   Sardaru, Dragos-Petrica
   Trofin, Dan
   Onita, Cristiana Amalia
   Iordan, Daniel-Andrei
   Matei, Daniela-Viorelia
TI Integrative Strategies for Preventing and Managing Metabolic Syndrome:
   The Impact of Exercise and Diet on Oxidative Stress Reduction-A Review
SO LIFE-BASEL
LA English
DT Review
DE metabolic syndrome; oxidative stress; physical exercise; dietary
   strategies; ketogenic diet; Mediterranean diet; dietary approaches to
   stop hypertension; intermittent fasting; inflammation
ID STOP HYPERTENSION DASH; OBESITY-RELATED HYPERTENSION; FREE FATTY-ACIDS;
   LOW-CARBOHYDRATE; WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; AEROBIC EXERCISE;
   NERVOUS-SYSTEM; KETOGENIC DIET; BLOOD-PRESSURE
AB Metabolic syndrome (MetS) is characterized by central obesity, insulin resistance, hypertension, dyslipidemia, and chronic inflammation, significantly increasing the risk of cardiovascular disease and type 2 diabetes. Effective management of MetS is critical, with exercise being a key intervention. This review analyzed the effects of different exercise intensities-low, moderate, and high-intensity interval training (HIIT)-on metabolic health, oxidative stress (OS), inflammation, and cardiovascular function. A search of Medline, PEDro, and EBSCO identified 2251 articles, with 159 studies published between 1999 and 2025 included after screening. Low-intensity exercise improved insulin sensitivity, reduced OS markers (e.g., MDA, 8-OHdG), and enhanced antioxidant enzyme activity. Moderate-intensity exercise showed similar benefits with notable reductions in inflammatory markers (e.g., IL-1 beta, TNF-alpha). HIIT promoted fat loss and improved metabolic markers but temporarily increased OS and inflammation. Dietary strategies also play a critical role. The Mediterranean diet and Dietary Approaches to Stop Hypertension (DASH) diets are well established, emphasizing nutrient-dense foods like unsaturated fats and fiber to reduce inflammation and manage weight. The ketogenic diet (KD), a high-fat, low-carbohydrate approach, has recently gained attention for its metabolic benefits. KD induces ketosis, improving insulin sensitivity, reducing triglycerides, and enhancing fat oxidation. Studies show KD effectively reduces body weight and glucose levels, though long-term adherence and nutrient deficiencies remain challenges. Intermittent fasting also showed potential benefits, though effects on glucose metabolism were inconsistent. This review underscores the need for tailored approaches combining exercise, diet, and fasting to optimize MetS outcomes, offering integrative strategies for prevention and management.
C1 [Onu, Ana; Trofin, Daniela-Marilena; Tutu, Andrei] Grigore T Popa Univ Med & Pharm Iasi, Doctoral Sch, Iasi 700454, Romania.
   [Onu, Ilie; Galaction, Anca-Irina; Sardaru, Dragos-Petrica; Trofin, Dan; Onita, Cristiana Amalia; Matei, Daniela-Viorelia] Grigore T Popa Univ Med & Pharm Iasi, Fac Med Bioengn, Dept Biomed Sci, Iasi 700588, Romania.
   [Onita, Cristiana Amalia] Grigore T Popa Univ Med & Pharm Iasi, Ctr Obes Biobehav Expt Res, Dept Morpho Funct Sci Pathophysiol 2, Iasi 700115, Romania.
   [Iordan, Daniel-Andrei] Dunarea Jos Univ Galati, Fac Phys Educ & Sport, Dept Individual Sports & Kinetotherapy, Galati 800008, Romania.
   [Iordan, Daniel-Andrei] Dunarea Jos Univ Galati, Ctr Phys Therapy & Rehabil, Galati 800008, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy; Dunarea De Jos University Galati; Dunarea De Jos University
   Galati
RP Onu, I; Galaction, AI (corresponding author), Grigore T Popa Univ Med & Pharm Iasi, Fac Med Bioengn, Dept Biomed Sci, Iasi 700588, Romania.
EM chirila.ana@d.umfiasi.ro; dr.danielatrofin@gmail.com;
   andrei.tutu@umfiasi.ro; ilie.onu@umfiasi.ro; anca.galaction@umfiasi.ro;
   dragos-petrica.sardaru@umfiasi.ro; trofin.dan@umfiasi.ro;
   cristiana-amalia.onita@umfiasi.ro; daniel.iordan@ugal.ro;
   daniela.matei@umfiasi.ro
RI Galaction, Anca/MTC-4512-2025; Dragos Petrica, Sardaru/JRW-8972-2023;
   Onu, Ilie/AAA-6447-2020; Onu, Ana/KWU-9900-2024; Trofin,
   Dan/MTE-8918-2025; Iordan, Daniel/AAK-2206-2021
CR Agarwal P, 2023, NEUROLOGY, V100, pE2259, DOI 10.1212/WNL.0000000000207176
   Aghajani R, 2022, ARCH PHYSIOL BIOCHEM, V128, P1596, DOI 10.1080/13813455.2020.1784954
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Aleksandrova K, 2021, REDOX BIOL, V42, DOI 10.1016/j.redox.2021.101869
   Allen J, 2015, PROG MOL BIOL TRANSL, V135, P337, DOI 10.1016/bs.pmbts.2015.07.003
   Almabruk Bandar A, 2024, Cureus, V16, pe71623, DOI 10.7759/cureus.71623
   Amadio P, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21207560
   López-Espinoza MA, 2021, NUTRIENTS, V13, DOI 10.3390/nu13092946
   Angelico F, 2023, INTERN EMERG MED, V18, P1007, DOI 10.1007/s11739-023-03226-7
   [Anonymous], 2018, Recommendations for Physical Activity in Adults and Kids
   Arab A, 2022, NUTR NEUROSCI, V25, P2259, DOI 10.1080/1028415X.2021.1954294
   Armstrong L., 2006, ACSM's Guidelines for Exercise Testing and Prescription, Vseventh
   ARONNE LJ, 1995, AM J PHYSIOL-REG I, V269, pR222, DOI 10.1152/ajpregu.1995.269.1.R222
   Asemi Z, 2014, NUTRITION, V30, P1287, DOI 10.1016/j.nut.2014.03.008
   Bahrami A, 2022, TURK J ENDOCRINOL ME, V26, P141, DOI 10.5152/tjem.2022.22047
   Bakaloudi DR, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051514
   Balistreri CR, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/802078
   Barati E, 2019, BIOCHEM GENET, V57, P695, DOI 10.1007/s10528-019-09913-5
   Battezzati A, 2023, NUTRIENTS, V15, DOI 10.3390/nu15051119
   Blaha MJ, 2016, HEART, V102, P431, DOI 10.1136/heartjnl-2015-308537
   Branyan KW, 2018, MED SCI SPORT EXER, V50, P957, DOI 10.1249/MSS.0000000000001531
   Brinkworth GD, 2009, AM J CLIN NUTR, V90, P23, DOI 10.3945/ajcn.2008.27326
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   Buchheit M, 2013, SPORTS MED, V43, P313, DOI 10.1007/s40279-013-0029-x
   Bueno NB, 2013, BRIT J NUTR, V110, P1178, DOI 10.1017/S0007114513000548
   Carroll S, 2004, SPORTS MED, V34, P371, DOI 10.2165/00007256-200434060-00004
   Castro-Barquero S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12102983
   Chang SW, 2024, RES SPORTS MED, V32, P871, DOI 10.1080/15438627.2024.2349521
   Chu B., 2025, Physiology, Stress Reaction
   Clemente-Suárez VJ, 2023, BIOMEDICINES, V11, DOI 10.3390/biomedicines11051290
   Coretti M, 2025, SPORTS MED HLTH SCI, V7, P77, DOI 10.1016/j.smhs.2024.08.002
   Cramer H, 2016, EUR J PREV CARDIOL, V23, P1982, DOI 10.1177/2047487316665729
   D'Alleva M, 2023, J EXERC SCI FIT, V21, P193, DOI 10.1016/j.jesf.2023.01.004
   Daneshzad E, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.775543
   Daniela M, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11020350
   Dasso NA, 2019, NURS FORUM, V54, P45, DOI 10.1111/nuf.12296
   de Araujo GG, 2016, FRONT PHYSIOL, V7, DOI 10.3389/fphys.2016.00505
   de Sousa CV, 2017, SPORTS MED, V47, P277, DOI 10.1007/s40279-016-0566-1
   Dekleva M, 2017, HYPERTENS RES, V40, P15, DOI 10.1038/hr.2016.90
   Di Raimondo D, 2021, NUTRIENTS, V13, DOI 10.3390/nu13082567
   Dominguez LJ, 2023, EXP GERONTOL, V174, DOI 10.1016/j.exger.2023.112121
   Dun YS, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0907-0
   Ebbert JO, 2013, NUTRIENTS, V5, P498, DOI 10.3390/nu5020498
   Eed R., 2021, J. Home Econ.Menofia Univ, V31, P1
   Estruch R, 2018, NEW ENGL J MED, V378, DOI [10.1056/NEJMoa1800389, 10.1056/NEJMoa1200303, 10.1056/nejmoa1800389]
   Fagius J, 2003, ACTA PHYSIOL SCAND, V177, P337, DOI 10.1046/j.1365-201X.2003.01086.x
   Fan HX, 2023, DIABETOL METAB SYNDR, V15, DOI 10.1186/s13098-023-01052-7
   Farinha JB, 2015, SPORTS MED-OPEN, V1, DOI 10.1186/s40798-015-0011-2
   Filippou Christina D, 2024, Hellenic J Cardiol, DOI 10.1016/j.hjc.2024.05.006
   Forsythe CE, 2008, LIPIDS, V43, P65, DOI 10.1007/s11745-007-3132-7
   Ghareeb D, 2021, J DIABETES METAB DIS, V20, P209, DOI 10.1007/s40200-021-00732-3
   Gibala MJ, 2008, EXERC SPORT SCI REV, V36, P58, DOI 10.1097/JES.0b013e318168ec1f
   Gleeson M, 2011, NAT REV IMMUNOL, V11, P607, DOI 10.1038/nri3041
   Gómez-Sánchez L, 2024, NUTRIENTS, V16, DOI 10.3390/nu16121948
   Guarino D, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00665
   Guasch-Ferré M, 2021, J INTERN MED, V290, P549, DOI 10.1111/joim.13333
   Guo Y, 2021, J CLIN ENDOCR METAB, V106, P64, DOI 10.1210/clinem/dgaa644
   Hallberg SJ, 2018, DIABETES THER, V9, P583, DOI 10.1007/s13300-018-0373-9
   Hoyas I, 2019, J CLIN MED, V8, DOI 10.3390/jcm8091301
   Hsu CN, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222111872
   Ilyas M.N., 2017, Curr. Trends Biomed. Eng. Biosci, V10, P1
   Kalil GZ, 2012, HYPERTENS RES, V35, P4, DOI 10.1038/hr.2011.173
   Khella MS, 2017, BMC MED GENET, V18, DOI 10.1186/s12881-017-0461-0
   Khoshnaw DM, 2021, J INTEGR MED-JIM, V19, P6, DOI 10.1016/j.joim.2020.09.002
   Kim Y, 2022, CLIN NUTR, V41, P2156, DOI 10.1016/j.clnu.2022.07.038
   Ko EJ, 2022, GENES GENOM, V44, P659, DOI 10.1007/s13258-022-01246-9
   Koch L, 2008, J CLIN INVEST, V118, P2132, DOI 10.1172/JCI31073
   Kochetova OV, 2019, MOL BIOL REP, V46, P887, DOI 10.1007/s11033-018-4544-6
   Landsberg L, 2001, J HYPERTENS, V19, P523, DOI 10.1097/00004872-200103001-00001
   Larsson SC, 2016, STROKE, V47, P986, DOI 10.1161/STROKEAHA.116.012675
   Lebovitz HE, 2001, EXP CLIN ENDOCR DIAB, V109, pS135, DOI 10.1055/s-2001-18576
   Lee S, 2014, J EXERC REHABIL, V10, P54, DOI 10.12965/jer.140100
   Lent-Schochet D, 2019, WORLD J DIABETES, V10, P23, DOI 10.4239/wjd.v10.i1.23
   Leon BM, 2015, WORLD J DIABETES, V6, P1246, DOI 10.4239/wjd.v6.i13.1246
   Li L, 2022, MEDICINE, V101, DOI 10.1097/MD.0000000000032246
   Lin ZF, 2013, CELL METAB, V17, P779, DOI 10.1016/j.cmet.2013.04.005
   Liu JX, 2019, AGING CLIN EXP RES, V31, P575, DOI 10.1007/s40520-018-1012-z
   Lopes Heno Ferreira, 2006, Arq. Bras. Cardiol., V87, P538, DOI 10.1590/S0066-782X2006001700022
   Lopes HF, 2003, HYPERTENSION, V41, P422, DOI 10.1161/01.HYP.0000053450.19998.11
   Luo W, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.1092031
   Lv YT, 2024, DIABET METAB SYND OB, V17, P3103, DOI 10.2147/DMSO.S477739
   Lwow F, 2011, MENOPAUSE, V18, P646, DOI 10.1097/gme.0b013e3182038ec1
   Mano-Otagiri A, 2009, J ENDOCRINOL, V201, P341, DOI 10.1677/JOE-08-0374
   Manoogian ENC, 2024, ANN INTERN MED, V177, DOI 10.7326/M24-0859
   Mendoza-Núñez VM, 2018, CLIN INTERV AGING, V13, P523, DOI 10.2147/CIA.S157584
   Martini D, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081802
   Masenga SK, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24097898
   Masood SH, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-48402-z
   Menotti A, 1999, EUR J EPIDEMIOL, V15, P507, DOI 10.1023/A:1007529206050
   Merra G, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010007
   Mezhal F, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph192113757
   Milano A, 2022, HUM NUTR METAB, V30, DOI 10.1016/j.hnm.2022.200175
   Monserrat-Mesquida M, 2024, ANTIOXIDANTS-BASEL, V13, DOI 10.3390/antiox13040450
   Monserrat-Mesquida M, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9030236
   Morton GJ, 2006, NATURE, V443, P289, DOI 10.1038/nature05026
   Myers MG, 2008, ANNU REV PHYSIOL, V70, P537, DOI 10.1146/annurev.physiol.70.113006.100707
   Niknam M, 2015, J AM COLL NUTR, V34, P408, DOI 10.1080/07315724.2014.943851
   Nishii Kazuhiro, 2023, Fujita Med J, V9, P171, DOI 10.20407/fmj.2022-020
   Nogueiras R, 2007, J CLIN INVEST, V117, P3475, DOI 10.1172/JCI31743
   Nojima H, 2008, METABOLISM, V57, P170, DOI 10.1016/j.metabol.2007.08.021
   Nordmann AJ, 2006, ARCH INTERN MED, V166, P285, DOI 10.1001/archinte.166.3.285
   Oliveira Jamille Silva, 2018, J. vasc. bras., V17, P141, DOI 10.1590/1677-5449.007917
   Ostman C, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-017-0590-y
   Ouchi N, 2010, SCIENCE, V329, P454, DOI 10.1126/science.1188280
   Paoli A, 2020, J TRANSL MED, V18, DOI 10.1186/s12967-020-02277-0
   Parvaresh A, 2019, COMPLEMENT THER MED, V47, DOI 10.1016/j.ctim.2019.08.021
   Patil SG, 2014, J CLIN DIAGN RES, V8, pBC4, DOI 10.7860/JCDR/2014/9498.4586
   Peterman M., 1926, J NERVOUS MENTAL DIS, V64, P96, DOI DOI 10.1097/00005053-192607000-00074
   Piercy KL, 2018, JAMA-J AM MED ASSOC, V320, P2020, DOI 10.1001/jama.2018.14854
   Pirouzeh R, 2020, DIABETES METAB SYND, V14, P2131, DOI 10.1016/j.dsx.2020.10.031
   Aro CEP, 2015, MEDWAVE, V15, DOI 10.5867/medwave.2015.07.6212
   Price RB, 2020, MOL PSYCHIATR, V25, P530, DOI 10.1038/s41380-019-0615-x
   Promsrisuk T, 2023, J EXERC REHABIL, V19, P114, DOI 10.12965/jer.2346040.020
   Qasem A, 2019, BMJ OPEN GASTROENTER, V6, DOI 10.1136/bmjgast-2018-000246
   Rafiullah M, 2022, NUTR REV, V80, P488, DOI 10.1093/nutrit/nuab040
   Rao DS, 2025, ITAL J MED, V19, DOI 10.4081/itjm.2025.1908
   Rathor P., 2024, Dietetics, V3, P289, DOI [10.3390/dietetics3030023, DOI 10.3390/DIETETICS3030023]
   Rees K, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009825.pub3
   Reis CEG, 2010, NUTR HOSP, V25, P881, DOI 10.3305/nh.2010.25.6.4760
   Román GC, 2019, REV NEUROL-FRANCE, V175, P705, DOI 10.1016/j.neurol.2019.07.017
   Romero-Vera L, 2024, LIFE-BASEL, V14, DOI 10.3390/life14121661
   Rosado-Pérez J, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18073458
   Rosado-Pérez J, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/298590
   Rytz CL, 2020, J APPL PHYSIOL, V128, P748, DOI 10.1152/japplphysiol.00667.2019
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Saneei P, 2014, NUTR METAB CARDIOVAS, V24, P1253, DOI 10.1016/j.numecd.2014.06.008
   Sangouni AA, 2024, BMC ENDOCR DISORD, V24, DOI 10.1186/s12902-024-01661-x
   Sarkar S, 2021, APUNTS SPORTS MED, V56, DOI 10.1016/j.apunsm.2021.100352
   Savas EM, 2020, METAB SYNDR RELAT D, V18, P197, DOI 10.1089/met.2019.0074
   Scheele C, 2009, TRENDS ENDOCRIN MET, V20, P95, DOI 10.1016/j.tem.2008.12.002
   Shirani F, 2013, NUTRITION, V29, P939, DOI 10.1016/j.nut.2012.12.021
   Sidabutar LMGB, 2022, CURR RES NUTR FOOD S, V10, P512, DOI 10.12944/CRNFSJ.10.2.8
   Smekal A, 2017, BIOMED PAP, V161, P31, DOI 10.5507/bp.2017.002
   Soltani S, 2018, CLIN NUTR, V37, P542, DOI 10.1016/j.clnu.2017.02.018
   Song P, 2022, NUTRIENTS, V14, DOI 10.3390/nu14245301
   Suarez R, 2024, CURR NUTR REP, V13, P516, DOI 10.1007/s13668-024-00556-6
   Suwala S, 2024, BIOMEDICINES, V12, DOI 10.3390/biomedicines12081739
   Swarup S., 2024, StatPearls Internet
   Tahapary Dicky Levenus, 2022, Diabetes Metab Syndr, V16, P102581, DOI 10.1016/j.dsx.2022.102581
   Tay J, 2008, J AM COLL CARDIOL, V51, P59, DOI 10.1016/j.jacc.2007.08.050
   Theander-Carrillo C, 2006, J CLIN INVEST, V116, P1983, DOI 10.1172/JCI25811
   Tjonna AE, 2008, CIRCULATION, V118, P346, DOI 10.1161/CIRCULATIONAHA.108.772822
   Trichopoulou A, 2014, BMC MED, V12, DOI 10.1186/1741-7015-12-112
   Tripathy D, 2003, DIABETES, V52, P2882, DOI 10.2337/diabetes.52.12.2882
   Tsygankova DP, 2023, RUSS OPEN MED J, V12, DOI 10.15275/rusomj.2023.0302
   Valenzuela-Fuenzalida JJ, 2024, NUTRIENTS, V16, DOI 10.3390/nu16183054
   Valipur G., 2014, ijdld, V13, P352
   Vasim I, 2022, NUTRIENTS, V14, DOI 10.3390/nu14030631
   Venugopal V, 2022, CURR DIABETES REV, V18, DOI 10.2174/1573399817666210405104335
   Vrdoljak J, 2022, NUTRIENTS, V14, DOI 10.3390/nu14030456
   Wang J, 2023, EMBO REP, V24, DOI 10.15252/embr.202357176
   Wang Minghan, 2005, Nutr Metab (Lond), V2, P3, DOI 10.1186/1743-7075-2-3
   Weiss EP, 2017, MED SCI SPORT EXER, V49, P206, DOI 10.1249/MSS.0000000000001074
   Yanai H, 2008, NUTR J, V7, DOI 10.1186/1475-2891-7-10
   Yancy WS, 2004, ANN INTERN MED, V140, P769, DOI 10.7326/0003-4819-140-10-200405180-00006
   Yang Z, 2021, NUTRITION, V89, DOI 10.1016/j.nut.2021.111230
   Yuan XJ, 2020, NUTR DIABETES, V10, DOI 10.1038/s41387-020-00142-z
   Zhu HY, 2022, SIGNAL TRANSDUCT TAR, V7, DOI 10.1038/s41392-021-00831-w
   Zúnica-García S, 2024, J ENDOCRINOL INVEST, V47, P2603, DOI 10.1007/s40618-024-02341-2
NR 159
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD MAY 8
PY 2025
VL 15
IS 5
AR 757
DI 10.3390/life15050757
PG 40
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA 3CD3W
UT WOS:001496816600001
PM 40430185
DA 2025-06-11
ER

PT J
AU Li, ZL
   Woollard, JR
   Wang, SM
   Korsmo, MJ
   Ebrahimi, B
   Grande, JP
   Textor, SC
   Lerman, A
   Lerman, LO
AF Li, Zilun
   Woollard, John R.
   Wang, Shenming
   Korsmo, Michael J.
   Ebrahimi, Behzad
   Grande, Joseph P.
   Textor, Stephen C.
   Lerman, Amir
   Lerman, Lilach O.
TI Increased glomerular filtration rate in early metabolic syndrome is
   associated with renal adiposity and microvascular proliferation
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE renal function; obesity
ID CHRONIC KIDNEY-DISEASE; CORONARY ENDOTHELIAL DYSFUNCTION; TYPE-1
   DIABETES-MELLITUS; EARLY ATHEROSCLEROSIS; OXIDATIVE STRESS; ARTERY
   STENOSIS; EXPERIMENTAL HYPERCHOLESTEROLEMIA; RENOVASCULAR DISEASE;
   STENOTIC KIDNEY; NITRIC-OXIDE
AB Li Z, Woollard JR, Wang S, Korsmo MJ, Ebrahimi B, Grande JP, Textor SC, Lerman A, Lerman LO. Increased glomerular filtration rate in early metabolic syndrome is associated with renal adiposity and microvascular proliferation. Am J Physiol Renal Physiol 301: F1078-F1087, 2011. First published July 20, 2011; doi:10.1152/ajprenal.00333.2011.-Metabolic syndrome (MetS) is associated with glomerular hyperfiltration and is a risk factor for chronic kidney disease, but the underlying mechanisms are poorly defined. This study tested the hypothesis that increased glomerular filtration rate (GFR) in early MetS is associated with renal adiposity and microvascular proliferation. Twelve MetS-prone Ossabaw pigs were randomized to 10 wk of a standard (lean, n = 6) or atherogenic (MetS, n = 6) diet. Kidney hemodynamics and function, perirenal fat volume, and tubular dynamics were assessed in vivo by multidetector computed tomography (CT) and blood oxygen level-dependent (BOLD)-MRI. Microvascular architecture was assessed ex vivo with micro-CT. Candidate injury mechanisms were evaluated in kidney tissue by Western blotting and histology. Basal GFR, renal blood flow, and renal cortical perfusion and volume were elevated in the MetS group. Perirenal and kidney tissue fat, proximal-nephron intratubular fluid concentration, and endothelial nitric oxide synthase expression were increased in MetS. GFR levels correlated with tissue triglyceride levels. Elevated spatial density of 20- to 40-mu m cortical microvessels was accompanied by mild oxidative stress, inflammation, and with proximal tubular vacuolization. Medullary size and perfusion were relatively preserved, and BOLD-MRI showed intact medullary tubular response to furosemide. Increased GFR in early MetS is associated with renal adiposity and microvascular proliferation, which involve mainly the renal cortex and precede significant activation of oxidative stress and inflammation. Renal adiposity and proliferative microvessels may represent novel therapeutic targets for preserving renal function in early MetS.
C1 [Li, Zilun; Woollard, John R.; Korsmo, Michael J.; Ebrahimi, Behzad; Textor, Stephen C.; Lerman, Lilach O.] Mayo Clin, Div Nephrol & Hypertens, Dept Internal Med, Rochester, MN 55905 USA.
   [Grande, Joseph P.] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA.
   [Lerman, Amir; Lerman, Lilach O.] Mayo Clin, Div Cardiovasc Dis, Rochester, MN 55905 USA.
   [Li, Zilun; Wang, Shenming] Sun Yat Sen Univ, Affiliated Hosp 1, Div Vasc Surg, Guangzhou 510275, Guangdong, Peoples R China.
C3 Mayo Clinic; Mayo Clinic; Mayo Clinic; Sun Yat Sen University
RP Lerman, LO (corresponding author), Mayo Clin, Div Nephrol & Hypertens, Dept Internal Med, 200 1st St SW, Rochester, MN 55905 USA.
EM lerman.lilach@mayo.edu
RI Lerman, Lilach/M-4962-2017; Grande, Joseph/AAG-2128-2020
OI Ebrahimi, Behzad/0000-0001-6907-7696
FU National Institutes of Health [DK73608, HL77131, HL085307,
   C06-RR018898]; China Scholarship Council under Ministry of Education of
   the People's Republic of China
FX This study was partly supported by National Institutes of Health Grants
   DK73608, HL77131, HL085307, and C06-RR018898. Z. Li is supported by the
   China Scholarship Council under the authority of the Ministry of
   Education of the People's Republic of China.
CR Ahima RS, 2000, TRENDS ENDOCRIN MET, V11, P327, DOI 10.1016/S1043-2760(00)00301-5
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Bosma RJ, 2006, CONTRIB NEPHROL, V151, P184, DOI 10.1159/000095329
   CASTELLOT JJ, 1980, P NATL ACAD SCI-BIOL, V77, P6007, DOI 10.1073/pnas.77.10.6007
   Chade AR, 2007, HYPERTENSION, V50, P729, DOI 10.1161/HYPERTENSIONAHA.107.093989
   Chade AR, 2003, HYPERTENSION, V42, P605, DOI 10.1161/01.HYP.0000089880.32275.7C
   Chade AR, 2005, HYPERTENSION, V46, P772, DOI 10.1161/01.HYP.0000184250.37607.da
   Chade AR, 2005, HYPERTENSION, V45, P1042, DOI 10.1161/01.HYP.0000167121.14254.a0
   Chade AR, 2004, J AM SOC NEPHROL, V15, P958, DOI 10.1097/01.ASN.0000117774.83396.E9
   Chade AR, 2003, ARTERIOSCL THROM VAS, V23, P1295, DOI 10.1161/01.ATV.0000077477.40824.52
   Chade AR, 2002, CIRCULATION, V106, P1165, DOI 10.1161/01.CIR.0000027105.02327.48
   Chiarelli F, 2000, DIABETES, V49, P1258, DOI 10.2337/diabetes.49.7.1258
   Coresh J, 2007, JAMA-J AM MED ASSOC, V298, P2038, DOI 10.1001/jama.298.17.2038
   Daghini E, 2007, RADIOLOGY, V243, P405, DOI 10.1148/radiol.2432060655
   Dyson MC, 2006, COMPARATIVE MED, V56, P35
   Favreau F, 2010, KIDNEY INT, V78, P1110, DOI 10.1038/ki.2010.142
   FOLKMAN J, 1982, ANN NY ACAD SCI, V401, P212, DOI 10.1111/j.1749-6632.1982.tb25720.x
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Galili O, 2007, AM J PHYSIOL-HEART C, V292, pH904, DOI 10.1152/ajpheart.00628.2006
   Ghajar CM, 2008, CRIT REV EUKAR GENE, V18, P251, DOI 10.1615/CritRevEukarGeneExpr.v18.i3.30
   Ghasemi A, 2010, EUR J EPIDEMIOL, V25, P45, DOI 10.1007/s10654-009-9382-3
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Jiang T, 2005, J BIOL CHEM, V280, P32317, DOI 10.1074/jbc.M500801200
   Koulouridis E, 2010, PEDIATR NEPHROL, V25, P491, DOI 10.1007/s00467-009-1364-x
   Kume S, 2007, J AM SOC NEPHROL, V18, P2715, DOI 10.1681/ASN.2007010089
   Lamacchia O, 2011, NEPHROL DIAL TRANSPL, V26, P892, DOI 10.1093/ndt/gfq522
   Lavi R, 2010, ARTERIOSCL THROM VAS, V30, P976, DOI 10.1161/ATVBAHA.109.201475
   Ma LJ, 2011, AM J PHYSIOL-RENAL, V300, pF1203, DOI 10.1152/ajprenal.00468.2010
   Mima A, 2011, KIDNEY INT, V79, P883, DOI 10.1038/ki.2010.526
   Montani JP, 2004, INT J OBESITY, V28, pS58, DOI 10.1038/sj.ijo.0802858
   Osmond JM, 2009, HYPERTENSION, V53, P381, DOI 10.1161/HYPERTENSIONAHA.108.124149
   Payne GA, 2010, ARTERIOSCL THROM VAS, V30, P1711, DOI 10.1161/ATVBAHA.110.210070
   Rega G, 2007, ARTERIOSCL THROM VAS, V27, P1587, DOI 10.1161/ATVBAHA.107.143081
   Rupnick MA, 2002, P NATL ACAD SCI USA, V99, P10730, DOI 10.1073/pnas.162349799
   Saito D, 2011, AM J PHYSIOL-RENAL, V300, pF873, DOI 10.1152/ajprenal.00503.2010
   Tantravahi JR, 2007, NAT CLIN PRACT NEPHR, V3, P474, DOI 10.1038/ncpneph0565
   Tomaszewski M, 2007, KIDNEY INT, V71, P816, DOI 10.1038/sj.ki.5002160
   Urbieta-Caceres VH, 2010, AM J PHYSIOL-RENAL, V299, pF135, DOI 10.1152/ajprenal.00159.2010
   Vallon V, 2003, J AM SOC NEPHROL, V14, P530, DOI 10.1097/01.ASN.0000051700.07403.27
   Vervoort G, 2005, EUR J CLIN INVEST, V35, P330, DOI 10.1111/j.1365-2362.2005.01497.x
   Wahba IM, 2007, CLIN J AM SOC NEPHRO, V2, P550, DOI 10.2215/CJN.04071206
   Warner L, 2011, INVEST RADIOL, V46, P41, DOI 10.1097/RLI.0b013e3181f0213f
   Warner L, 2009, AM J PHYSIOL-REG I, V296, pR67, DOI 10.1152/ajpregu.90677.2008
   Zhu XY, 2006, ARTERIOSCL THROM VAS, V26, P1746, DOI 10.1161/01.ATV.0000227469.40826.01
   Zhu XY, 2004, ARTERIOSCL THROM VAS, V24, P1854, DOI 10.1161/01.ATV.0000142443.52606.81
   Zhu XY, 2004, CIRCULATION, V109, P2109, DOI 10.1161/01.CIR.0000125742.65841.8B
NR 46
TC 88
Z9 98
U1 0
U2 10
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD NOV
PY 2011
VL 301
IS 5
BP F1078
EP F1087
DI 10.1152/ajprenal.00333.2011
PG 10
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA 863GV
UT WOS:000298151700019
PM 21775485
OA Green Published
DA 2025-06-11
ER

PT J
AU Venturi, S
   Marino, M
   Cioffi, I
   Martini, D
   Del Bo', C
   Perna, S
   Riso, P
   Klimis-Zacas, D
   Porrini, M
AF Venturi, Samuele
   Marino, Mirko
   Cioffi, Iolanda
   Martini, Daniela
   Del Bo', Cristian
   Perna, Simone
   Riso, Patrizia
   Klimis-Zacas, Dorothy
   Porrini, Marisa
TI Berry Dietary Interventions in Metabolic Syndrome: New Insights
SO NUTRIENTS
LA English
DT Review
DE blueberry; raspberry; strawberry; cranberry; humans; dietary
   intervention; metabolic syndrome
ID OXIDATIVE STRESS; CRANBERRY JUICE; DOUBLE-BLIND; ENDOTHELIAL FUNCTION;
   BLACK-RASPBERRY; BLOOD-PRESSURE; UNITED-STATES; RISK-FACTORS;
   BLUEBERRIES; INFLAMMATION
AB Metabolic Syndrome (MetS) is characterized by a group of dysmetabolic conditions, including abdominal obesity, dyslipidemia, glucose intolerance and/or insulin resistance, and hypertension. Generally, MetS is accompanied by an exacerbation of oxidative stress, inflammation, and vascular dysfunction. Increasing evidence suggests that berries and berry bioactives could play a potential role in the prevention and mitigation of the risk factors associated with MetS. The present systematic review summarizes the more recently available evidence deriving from human intervention studies investigating the effect of berries in subjects with at least three out of five MetS parameters. The PubMed, Scopus, and Embase databases were systematically searched from January 2010 until December 2022. A total of 17 human intervention trials met the inclusion criteria. Most of them were focused on blueberry (n = 6), cranberry (n = 3), and chokeberry (n = 3), while very few or none were available for the other berries. If considering MetS features, the main positive effects were related to lipid profile (low and high-density lipoproteins, cholesterol, and triglycerides) following blueberries and chokeberries, while conflicting results were documented for anthropometric parameters, blood pressure, and fasting blood glucose levels. Other markers analyzed within the studies included vascular function, oxidative stress, and inflammation. Here, the main positive effects were related to inflammation with a reduction in interleukin 6 and tumor necrosis factor-alpha following the intake of different berries. In conclusion, although limited, the evidence seems to support a potential role for berries in the modulation of lipid profile and inflammation in subjects with MetS. Furthermore, high-quality intervention trials are mandatory to demonstrate the role of berries in reducing risk factors for MetS and related conditions. In the future, such a demonstration could bring the adoption of berries as a potential dietary strategy to prevent/counteract MetS and related risk factors.
C1 [Venturi, Samuele; Marino, Mirko; Cioffi, Iolanda; Martini, Daniela; Del Bo', Cristian; Perna, Simone; Riso, Patrizia; Porrini, Marisa] Univ Milan, Dept Food Environm & Nutr Sci, I-20133 Milan, Italy.
   [Klimis-Zacas, Dorothy] Univ Maine, Sch Food & Agr, Orono, ME 04469 USA.
C3 University of Milan; University of Maine System; University of Maine
   Orono
RP Del Bo', C (corresponding author), Univ Milan, Dept Food Environm & Nutr Sci, I-20133 Milan, Italy.
EM samuele.venturi@unimi.it; mirko.marino@unimi.it;
   iolanda.cioffi@unimi.it; daniela.martini@unimi.it;
   cristian.delbo@unimi.it; simone.perna@unimi.it; patrizia.riso@unimi.it;
   dorothea@maine.edu; marisa.porrini@unimi.it
RI Marino, Mirko/AAI-5389-2020; Cioffi, Iolanda/Q-1023-2019; Riso,
   Patrizia/AAC-2072-2019; Del Bò, Cristian/AFT-1534-2022; porrini,
   marisa/AAF-6788-2021; Martini, Daniela/S-2499-2019; Perna,
   Simone/Y-8892-2018; martini, daniela/D-6241-2015
OI Perna, Simone/0000-0002-2720-1473; DEL BO',
   CRISTIAN/0000-0001-7562-377X; MARINO, MIRKO/0000-0001-9913-4380;
   Venturi, Samuele/0000-0001-6473-1863; porrini,
   marisa/0000-0003-2693-3311; martini, daniela/0000-0001-8298-926X; Riso,
   Patrizia/0000-0002-9204-7257; Cioffi, Iolanda/0000-0002-1408-209X
FU Wild Blueberry Association of North America (WBANA); Belgium (FWO);
   France (INRA); Germany (BLE); Italy (MIPAAF); Latvia (IZM); Norway
   (RCN); Portugal (FCT); Spain (AEI) in the joint actions of JPI HDHL,
   JPI-OCEANS, and FACCE-JPI in 2019 under ERA-NET ERA-HDHL [696295]; Piano
   di sostegno alla Ricerca-Linea 2, azione A-grant [PSR2021_DMART,
   PSR2021_CDELB]; Universita degli Studi di Milano (PSR) [2021-GSA-Linea
   6]
FX C.D.B., P.R. and D.K.-Z. thank the Wild Blueberry Association of North
   America (WBANA) for their support. C.D.B., D.M. and P.R. thank the
   project SYSTEMIC: "An integrated approach to the challenge of
   sustainable food systems: adaptive and mitigatory strategies to address
   climate change and malnutrition" from the Knowledge Hub on Nutrition and
   Food Security that has received funding from national research funding
   parties in Belgium (FWO), France (INRA), Germany (BLE), Italy (MIPAAF),
   Latvia (IZM), Norway (RCN), Portugal (FCT), and Spain (AEI) in the joint
   actions of JPI HDHL, JPI-OCEANS, and FACCE-JPI launched in 2019 under
   ERA-NET ERA-HDHL (No. 696295). D.M. and C.D.B. extend thanks for the
   grant received from Piano di sostegno alla Ricerca-Linea 2, azione
   A-grant number PSR2021_DMART and PSR2021_CDELB. P.R. also acknowledges
   the project "One Health Action Hub: University Task Force for the
   resilience of territorial ecosystems" funded by Universita degli Studi
   di Milano (PSR 2021-GSA-Linea 6).
CR Ahles S, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22126482
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Basu A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051421
   Basu A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11091983
   Basu A, 2011, NUTR RES, V31, P190, DOI 10.1016/j.nutres.2011.02.003
   Basu A, 2010, NUTR RES, V30, P462, DOI 10.1016/j.nutres.2010.06.016
   Basu A, 2010, J NUTR, V140, P1582, DOI 10.3945/jn.110.124701
   Biondi G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23105522
   Bouyahya A, 2022, MOLECULES, V27, DOI 10.3390/molecules27103286
   Broncel M, 2010, MED SCI MONITOR, V16, pCR28
   Brunton SA, 2020, POSTGRAD MED, V132, P3, DOI 10.1080/00325481.2020.1798099
   Canoy D, 2022, CURR CARDIOL REP, V24, P851, DOI 10.1007/s11886-022-01706-4
   Cassidy A, 2013, CIRCULATION, V127, P188, DOI 10.1161/CIRCULATIONAHA.112.122408
   Chen LY, 2022, FOOD RES INT, V151, DOI 10.1016/j.foodres.2022.111202
   Simao TNC, 2013, BRIT J NUTR, V110, P1885, DOI 10.1017/S0007114513001207
   Cornell S, 2020, J CLIN PHARM THER, V45, P17, DOI 10.1111/jcpt.13230
   Cosme F, 2022, FOODS, V11, DOI 10.3390/foods11050644
   Cox AJ, 2015, LANCET DIABETES ENDO, V3, P207, DOI 10.1016/S2213-8587(14)70134-2
   Curtis PJ, 2022, CLIN NUTR, V41, P165, DOI 10.1016/j.clnu.2021.11.030
   Curtis PJ, 2019, AM J CLIN NUTR, V109, P1535, DOI 10.1093/ajcn/nqy380
   Dabke K, 2019, J CLIN INVEST, V129, P4050, DOI 10.1172/JCI129194
   Daneshzad E, 2019, CLIN NUTR, V38, P1153, DOI 10.1016/j.clnu.2018.06.979
   Davies MJ, 2022, DIABETOLOGIA, V65, P1925, DOI 10.1007/s00125-022-05787-2
   Dayi Taygun, 2022, J Prev Med Hyg, V63, pE56, DOI 10.15167/2421-4248/jpmh2022.63.2S3.2747
   Del Bo C, 2015, FOOD FUNCT, V6, P2890, DOI 10.1039/c5fo00657k
   Fairlie-Jones L, 2017, NUTRIENTS, V9, DOI 10.3390/nu9080908
   Fallah AA, 2020, J FUNCT FOODS, V68, DOI 10.1016/j.jff.2020.103912
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Golovinskaia O, 2021, MOLECULES, V26, DOI 10.3390/molecules26133904
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Higgins JPT., 2011, BMJ CLIN RES ED, V343, pd5928, DOI [10.1136/bmj.d5928, DOI 10.1136/BMJ.D5928]
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Hosseini B, 2018, AM J CLIN NUTR, V108, P136, DOI 10.1093/ajcn/nqy082
   Huang HH, 2016, SCI REP-UK, V6, DOI 10.1038/srep23625
   Inzucchi SE, 2015, DIABETES CARE, V38, P140, DOI 10.2337/dc14-2441
   Jennings A, 2014, J NUTR, V144, P202, DOI 10.3945/jn.113.184358
   Jeong HS, 2016, J MED FOOD, V19, P346
   Jeong HS, 2014, PHYTOTHER RES, V28, P1492, DOI 10.1002/ptr.5154
   Jiang HT, 2021, FOOD RES INT, V147, DOI 10.1016/j.foodres.2021.110539
   Joseph SV, 2014, J AGR FOOD CHEM, V62, P3886, DOI 10.1021/jf4044056
   Kimble R, 2019, CRIT REV FOOD SCI, V59, P3032, DOI 10.1080/10408398.2018.1509835
   Kolehmainen M, 2012, MOL NUTR FOOD RES, V56, P1501, DOI 10.1002/mnfr.201200195
   Kowalska K, 2016, CURR OPIN CLIN NUTR, V19, P446, DOI 10.1097/MCO.0000000000000322
   Lail HL, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020334
   Liang XP, 2021, EUR HEART J, V42, P2420
   Luís A, 2018, FOOD FUNCT, V9, P740, DOI [10.1039/c7fo01551h, 10.1039/C7FO01551H]
   Marino M, 2022, EUR J NUTR, V61, P1003, DOI 10.1007/s00394-021-02714-w
   Martini D, 2017, NUTR METAB CARDIOVAS, V27, P473, DOI 10.1016/j.numecd.2017.01.008
   Martini D, 2023, J NUTR BIOCHEM, V111, DOI 10.1016/j.jnutbio.2022.109154
   Martini D, 2020, NUTR REV, V78, P189, DOI 10.1093/nutrit/nuz053
   Mozos I, 2021, BIOMOLECULES, V11, DOI 10.3390/biom11060811
   Nair AR, 2017, FOOD FUNCT, V8, P4118, DOI [10.1039/c7fo00815e, 10.1039/C7FO00815E]
   Najjar RS, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11040616
   Nikparast Ali, 2023, Clin Nutr Res, V12, P54, DOI 10.7762/cnr.2023.12.1.54
   Nilsson PM, 2019, EUR J PREV CARDIOL, V26, P33, DOI 10.1177/2047487319886404
   Noubiap JJ, 2022, DIABETES RES CLIN PR, V188, DOI 10.1016/j.diabres.2022.109924
   Palma-Duran SA, 2017, CRIT REV FOOD SCI, V57, P975, DOI 10.1080/10408398.2014.973932
   Pap N, 2021, CURR OPIN FOOD SCI, V42, P167, DOI 10.1016/j.cofs.2021.06.003
   Picasso MC, 2019, CLIN NUTR, V38, P1117, DOI 10.1016/j.clnu.2018.05.021
   Puupponen-Pimiä R, 2013, MOL NUTR FOOD RES, V57, P2258, DOI 10.1002/mnfr.201300280
   Rambaran TF, 2020, CURR DEV NUTR, V4, DOI 10.1093/cdn/nzaa100
   Riordan J., 2022, BioMed, V2, P210, DOI 10.3390/biomed2020019
   Rodríguez-Monforte M, 2017, EUR J NUTR, V56, P925, DOI 10.1007/s00394-016-1305-y
   Ruel G, 2013, NUTR RES, V33, P41, DOI 10.1016/j.nutres.2012.11.002
   Salas-Salvadó J, 2016, J NUTR, V146, p920S, DOI 10.3945/jn.115.218487
   Schwingshackl L, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0140846
   Scuteri A, 2015, EUR J PREV CARDIOL, V22, P486, DOI 10.1177/2047487314525529
   Sikora J, 2012, EUR J NUTR, V51, P549, DOI 10.1007/s00394-011-0238-8
   Sobolev AP, 2019, METABOLITES, V9, DOI 10.3390/metabo9070138
   Sterne JAC, 2016, BMJ-BRIT MED J, V355, DOI 10.1136/bmj.i4919
   Stull AJ, 2015, NUTRIENTS, V7, P4107, DOI 10.3390/nu7064107
   Tasic N, 2021, MOL CELL BIOCHEM, V476, P2663, DOI 10.1007/s11010-021-04106-4
   Tsuda T, 2016, ANTIOXIDANTS-BASEL, V5, DOI 10.3390/antiox5020013
   Vendrame S, 2022, NUTRIENTS, V14, DOI 10.3390/nu14132701
   Vendrame S, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061431
   Vendrame S, 2016, ANTIOXIDANTS-BASEL, V5, DOI 10.3390/antiox5040034
   Wang PY, 2016, J DIABETES INVEST, V7, P56, DOI 10.1111/jdi.12376
   Wang YY, 2021, EUR J NUTR, V60, P615, DOI 10.1007/s00394-020-02299-w
   Wedick NM, 2012, AM J CLIN NUTR, V95, P925, DOI 10.3945/ajcn.111.028894
   WHO Consultation, 2000, WHO TECH REP SER, V894, P1
   Wilken Mikkel Roulund, 2022, Rev Diabet Stud, V18, P42, DOI 10.1900/RDS.2022.18.42
   World Health Organization, 2014, Global action plan for the prevention and control of noncommunicable diseases, 2013-2020
   Xie CH, 2011, MOL NUTR FOOD RES, V55, P1587, DOI 10.1002/mnfr.201100344
   Xu L, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.747884
   Zurbau A, 2020, J AM HEART ASSOC, V9, DOI 10.1161/JAHA.120.017728
NR 86
TC 6
Z9 6
U1 3
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2023
VL 15
IS 8
AR 1906
DI 10.3390/nu15081906
PG 22
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA E9KP2
UT WOS:000978647600001
PM 37111125
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cao, J
   Sodhi, K
   Puri, N
   Monu, SR
   Rezzani, R
   Abraham, NG
AF Cao, Jian
   Sodhi, Komal
   Puri, Nitin
   Monu, Sumit R.
   Rezzani, Rita
   Abraham, Nader G.
TI High fat diet enhances cardiac abnormalities in SHR rats: Protective
   role of heme oxygenase-adiponectin axis
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE heme oxygenase; adiponectin; high fat diet; COX-2; oxidative stress
ID SPONTANEOUSLY HYPERTENSIVE-RATS; ACTIVATED PROTEIN-KINASE; IMPROVES
   INSULIN SENSITIVITY; LOWERS BLOOD-PRESSURE; NECROSIS-FACTOR-ALPHA;
   ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; SUPEROXIDE-DISMUTASE
AB Background: High dietary fat intake is a major risk factor for development of cardiovascular and metabolic dysfunction including obesity, cardiomyopathy and hypertension.
   Methods: The present study was designed to examine effect of high fat (HF) diet on cardio-vascular structure and function in spontaneously hypertensive rats (SHR), fed HF diet for 15 weeks, a phenotype designed to mimic metabolic syndrome.
   Results: Development of metabolic syndrome like phenotype was confirmed using parameters, including body weight, total cholesterol and blood pressure levels. High fat diet impaired vascular relaxation by acetylcholine and exacerbated cardiac dysfunction in SHRs as evidenced by lower left ventricular function, and higher coronary resistance (CR) as compared to controls (p < 0.05). The histological examination revealed significant myocardial and peri-vascular fibrosis in hearts from SHRs on HF diet. This cardiac dysfunction was associated with increased levels of inflammatory cytokines, COX-2, NOX-2, TxB2 expression and increase in superoxide (O-2(-)) levels in SHR fed a HF diet (p < 0.05). HO-1 induction via cobalt-protoporphyrin (CoPP, 3 mg/kg), in HF fed rats, not only improved cardiac performance parameters, but also prevented myocardial and perivascular fibrosis. These effects of CoPP were accompanied by enhanced levels of cardiac adiponectin levels, pAMPK, peNOS and iNOS expression; otherwise significantly attenuated (p < 0.05) in HF fed SHRs. Prevention of such beneficial effects of CoPP by the concurrent administration of the HO inhibitor stannic mesoporphyrin (SnMP) corroborates the role of HO system in mediating such effects.
   Conclusion: In conclusion, this novel study demonstrates that up-regulation of HO-1 improves cardiac and vascular dysfunction by blunting oxidative stress, COX-2 levels and increasing adiponectin levels in hypertensive rats on HF diet.
C1 [Sodhi, Komal; Puri, Nitin; Monu, Sumit R.; Abraham, Nader G.] Univ Toledo, Coll Med, Dept Physiol & Pharmacol, Toledo, OH 43614 USA.
   [Cao, Jian] Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Cardiol, Beijing 100853, Peoples R China.
   [Rezzani, Rita] Univ Brescia, Div Anat, Dept Biomed Sci, Brescia, Italy.
C3 University System of Ohio; University of Toledo; Chinese People's
   Liberation Army General Hospital; University of Brescia
RP Abraham, NG (corresponding author), Univ Toledo, Coll Med, Dept Physiol & Pharmacol, Toledo, OH 43614 USA.
OI Cao, Jian/0000-0001-6728-4587; Monu, Sumit/0000-0003-1906-3063
FU NIH [DK068134, HL55601, HL34300]
FX This work was supported by NIH grants DK068134, HL55601 and HL34300
   (NGA).
CR Abraham NG, 2008, PHARMACOL REV, V60, P79, DOI 10.1124/pr.107.07104
   Abraham NG, 2007, HIGH SERUM LEVELS AD
   Berg AH, 2005, CIRC RES, V96, P939, DOI 10.1161/01.RES.0000163635.62927.34
   BING OHL, 1995, J MOL CELL CARDIOL, V27, P383, DOI 10.1016/S0022-2828(08)80035-1
   Botros FT, 2005, KIDNEY INT, V68, P2745, DOI 10.1111/j.1523-1755.2005.00745.x
   Buja LM, 2005, CARDIOVASC PATHOL, V14, P170, DOI 10.1016/j.carpath.2005.03.006
   Cao J, 2008, INT J MOL SCI, V9, P2388, DOI 10.3390/ijms9122388
   Cao J, 2009, INT J BIOCHEM CELL B, V41, P1025, DOI 10.1016/j.biocel.2008.10.025
   Chen ZP, 1999, FEBS LETT, V443, P285, DOI 10.1016/S0014-5793(98)01705-0
   Dimmeler S, 1999, NATURE, V399, P601, DOI 10.1038/21224
   Dobrian AD, 2001, HYPERTENSION, V37, P554, DOI 10.1161/01.HYP.37.2.554
   Dobrian AD, 2000, HYPERTENSION, V35, P1009, DOI 10.1161/01.HYP.35.4.1009
   Dunlay SM, 2008, CIRCULATION, V118, P625, DOI 10.1161/CIRCULATIONAHA.107.759191
   Erdei N, 2006, AM J PHYSIOL-HEART C, V291, pH2107, DOI 10.1152/ajpheart.00389.2006
   Galili O, 2007, AM J PHYSIOL-HEART C, V292, pH904, DOI 10.1152/ajpheart.00628.2006
   GARRISON RJ, 1987, PREV MED, V16, P235, DOI 10.1016/0091-7435(87)90087-9
   Hall JE, 2003, HYPERTENSION, V41, P625, DOI 10.1161/01.HYP.0000052314.95497.78
   Hardie DG, 2003, ENDOCRINOLOGY, V144, P5179, DOI 10.1210/en.2003-0982
   Hopkins TA, 2007, CARDIOVASC RES, V74, P11, DOI 10.1016/j.cardiores.2006.10.009
   Huang KC, 2003, J CLIN ENDOCR METAB, V88, P4130, DOI 10.1210/jc.2003-030158
   Iwasa Y, 2008, NEPHRON CLIN PRACT, V108, pC226, DOI 10.1159/000119717
   Iwashima Y, 2004, HYPERTENSION, V43, P1318, DOI 10.1161/01.HYP.0000129281.03801.4b
   Ix JH, 2010, J AM SOC NEPHROL, V21, P406, DOI 10.1681/ASN.2009080820
   Kenchaiah S, 2002, NEW ENGL J MED, V347, P305, DOI 10.1056/NEJMoa020245
   Kim DH, 2008, J PHARMACOL EXP THER, V325, P833, DOI 10.1124/jpet.107.135285
   Knight SF, 2008, HYPERTENSION, V51, P352, DOI 10.1161/HYPERTENSIONAHA.107.099499
   Kruger AL, 2005, CIRCULATION, V111, P3126, DOI 10.1161/CIRCULATIONAHA.104.517102
   Kudo N, 1996, BBA-LIPID LIPID MET, V1301, P67, DOI 10.1016/0005-2760(96)00013-6
   KWAK JY, 1991, BIOCHIM BIOPHYS ACTA, V1076, P369, DOI 10.1016/0167-4838(91)90478-I
   L'Abbate A, 2007, AM J PHYSIOL-HEART C, V293, pH3532, DOI 10.1152/ajpheart.00826.2007
   Lara-Castro C, 2006, DIABETES, V55, P249, DOI 10.2337/diabetes.55.01.06.db05-1105
   Li M, 2008, DIABETES, V57, P1526, DOI 10.2337/db07-1764
   Li M, 2007, ANTIOXID REDOX SIGN, V9, P855, DOI 10.1089/ars.2007.1568
   Li Volti G, 2003, HYPERTENSION, V41, P715, DOI 10.1161/01.HYP.0000049163.23426.66
   Mathew AV, 2011, CURR DIABETES REV, V7, P41, DOI 10.2174/157339911794273928
   Merrill GF, 1997, AM J PHYSIOL-ENDOC M, V273, pE1107, DOI 10.1152/ajpendo.1997.273.6.E1107
   Molnar J, 2005, CIRC RES, V96, P1178, DOI 10.1161/01.RES.0000168634.74330.ed
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Nicolai A, 2009, HYPERTENSION, V53, P508, DOI 10.1161/HYPERTENSIONAHA.108.124701
   Paolocci N, 2001, J MOL CELL CARDIOL, V33, P671, DOI 10.1006/jmcc.2000.1334
   Peterson SJ, 2008, J LIPID RES, V49, P1658, DOI 10.1194/jlr.M800046-JLR200
   Peterson SJ, 2009, J LIPID RES, V50, P1293, DOI 10.1194/jlr.M800610-JLR200
   Ran JM, 2010, DIABETES RES CLIN PR, V88, P177, DOI 10.1016/j.diabres.2010.01.021
   Roberts CK, 2006, METABOLISM, V55, P928, DOI 10.1016/j.metabol.2006.02.022
   Sabaawy HE, 2001, HYPERTENSION, V38, P210, DOI 10.1161/01.HYP.38.2.210
   SACERDOTI D, 1989, SCIENCE, V243, P388, DOI 10.1126/science.2492116
   Sambuceti G, 2009, STEM CELLS, V27, P399, DOI 10.1634/stemcells.2008-0800
   SARDANA MK, 1987, P NATL ACAD SCI USA, V84, P2464, DOI 10.1073/pnas.84.8.2464
   Satoh Mamoru, 2008, Curr Heart Fail Rep, V5, P69, DOI 10.1007/s11897-008-0012-2
   Schreyer SA, 1998, ATHEROSCLEROSIS, V136, P17, DOI 10.1016/S0021-9150(97)00165-2
   Schulz E, 2008, CIRCULATION, V118, P1347, DOI 10.1161/CIRCULATIONAHA.108.784298
   Sodhi K, 2009, J PHARMACOL EXP THER, V331, P906, DOI 10.1124/jpet.109.157545
   SURWIT RS, 1988, DIABETES, V37, P1163, DOI 10.2337/diabetes.37.9.1163
   Terai K, 2005, MOL CELL BIOL, V25, P9554, DOI 10.1128/MCB.25.21.9554-9575.2005
   Turkseven S, 2005, AM J PHYSIOL-HEART C, V289, pH701, DOI 10.1152/ajpheart.00024.2005
   Wu LY, 2005, PHARMACOL REV, V57, P585, DOI 10.1124/pr.57.4.3
   Zalesin KC, 2011, MED CLIN N AM, V95, P919, DOI 10.1016/j.mcna.2011.06.005
NR 57
TC 39
Z9 46
U1 0
U2 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD DEC 23
PY 2011
VL 3
AR 37
DI 10.1186/1758-5996-3-37
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 878MQ
UT WOS:000299261600001
PM 22196253
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yafi, FA
   Jenkins, L
   Albersen, M
   Corona, G
   Isidori, A
   Goldfarb, S
   Maggi, M
   Nelson, CJ
   Parish, S
   Salonia, A
   Tan, R
   Mulhall, JP
   Hellstrom, WJG
AF Yafi, Faysal A.
   Jenkins, Lawrence
   Albersen, Maarten
   Corona, Giovanni
   Isidori, AndreaM.
   Goldfarb, Shari
   Maggi, Mario
   Nelson, Christian J.
   Parish, Sharon
   Salonia, Andrea
   Tan, Ronny
   Mulhall, John P.
   Hellstrom, Wayne J. G.
TI Erectile dysfunction
SO NATURE REVIEWS DISEASE PRIMERS
LA English
DT Article
ID STANDARD OPERATING PROCEDURES; URINARY-TRACT SYMPTOMS; CAVERNOUS NERVE
   INJURY; QUALITY-OF-LIFE; SERUM TESTOSTERONE LEVELS; MALE SEXUAL
   DYSFUNCTION; TERM-FOLLOW-UP; 69 YEARS OLD; CORPUS CAVERNOSUM;
   SMOOTH-MUSCLE
AB Erectile dysfunction is a multidimensional but common male sexual dysfunction that involves an alteration in any of the components of the erectile response, including organic, relational and psychological. Roles for nonendocrine (neurogenic, vasculogenic and iatrogenic) and endocrine pathways have been proposed. Owing to its strong association with metabolic syndrome and cardiovascular disease, cardiac assessment may be warranted in men with symptoms of erectile dysfunction. Minimally invasive interventions to relieve the symptoms of erectile dysfunction include lifestyle modifications, oral drugs, injected vasodilator agents and vacuum erection devices. Surgical therapies are reserved for the subset of patients who have contraindications to these nonsurgical interventions, those who experience adverse effects from (or are refractory to) medical therapy and those who also have penile fibrosis or penile vascular insufficiency. Erectile dysfunction can have deleterious effects on a man's quality of life; most patients have symptoms of depression and anxiety related to sexual performance. These symptoms, in turn, affect his partner's sexual experience and the couple's quality of life. This Primer highlights numerous aspects of erectile dysfunction, summarizes new treatment targets and ongoing preclinical studies that evaluate new pharmacotherapies, and covers the topic of regenerative medicine, which represents the future of sexual medicine.
C1 [Yafi, Faysal A.; Hellstrom, Wayne J. G.] Tulane Univ, Sch Med, Dept Urol, Box SL 42,1430 Tulane Ave, New Orleans, LA 70112 USA.
   [Jenkins, Lawrence; Mulhall, John P.] Mem Sloan Kettering Canc Ctr, Sexual & Reprod Med Program, 1275 York Ave, New York, NY 10065 USA.
   [Albersen, Maarten] Univ Leuven, Dept Dev & Regenerat, Lab Expt Urol Gene & Stem Cells Applicat, Leuven, Belgium.
   [Corona, Giovanni] Maggiore Bellaria Hosp, Endocrinol Unit, Bologna, Italy.
   [Isidori, AndreaM.] Sapienza Univ Rome, Dept Expt Med, Rome, Italy.
   [Goldfarb, Shari; Nelson, Christian J.] Mem Sloan Kettering Canc Ctr, Dept Psychiat & Behav Sci, 1275 York Ave, New York, NY 10021 USA.
   [Maggi, Mario] Univ Florence, Dept Expt Clin & Biomed Sci, Sexual Med & Androl Unit, Florence, Italy.
   [Parish, Sharon] Albert Einstein Coll Med, Med, Dept Med, Bronx, NY 10467 USA.
   [Salonia, Andrea] IRCCS Osped San Raffaele, Unit Urol, Div Expt Oncol, Milan, Italy.
   [Tan, Ronny] Tan Tock Seng Hosp, Dept Urol, Singapore, Singapore.
C3 Tulane University; Memorial Sloan Kettering Cancer Center; KU Leuven;
   AUSL di Bologna; Sapienza University Rome; Memorial Sloan Kettering
   Cancer Center; University of Florence; Yeshiva University; Montefiore
   Medical Center; Albert Einstein College of Medicine; Vita-Salute San
   Raffaele University; IRCCS Ospedale San Raffaele; Tan Tock Seng Hospital
RP Hellstrom, WJG (corresponding author), Tulane Univ, Sch Med, Dept Urol, Box SL 42,1430 Tulane Ave, New Orleans, LA 70112 USA.; Mulhall, JP (corresponding author), Mem Sloan Kettering Canc Ctr, Sexual & Reprod Med Program, 1275 York Ave, New York, NY 10065 USA.
EM mulhalj1@mskcc.org; whellst@tulane.edu
RI Isidori, Andrea/F-3062-2010; Jenkins, Lawrence/P-1888-2019; Maggi,
   Mario/AAB-8284-2019; Stefanadis, Christodoulos/ABH-2232-2020; Salonia,
   Andrea/H-1025-2016
OI Stefanadis, Christodoulos/0000-0001-5974-6454; Nelson,
   Christian/0000-0003-2141-6489; Salonia, Andrea/0000-0002-0595-7165;
   Isidori, Andrea/0000-0002-9037-5417; Jenkins, Lawrence
   C/0000-0003-0125-673X; Hellstrom, Wayne/0000-0003-1284-959X
FU Ferring; Bayer; ESSM; ISSM; Besins; Otsuka; Eli-Lilly; Menarini;
   Prostrakan; Intercept; Pfizer; Lilly; CIACT; NIH; SMSNA; American
   Medical Systems
FX M.A. has received grants from Ferring, Bayer, ESSM and ISSM, and served
   as an advisor for Sandoz, Sobi and Sanofi. G.C. has received consultancy
   fees from Bayer, Besins, Otsuka, Eli-Lilly and Menarini. A.M.I. has
   served as an advisor for Otsuka, Shire, Besins, Novartis and Menarini.
   M.M. has served as an advisor and/or received speaker's fees from Bayer,
   Ely Lilly, Menarini, Prostrakan and Intercept. C.J.N. has served as an
   unpaid advisor for American Medical Systems. S.P. has served as an
   advisor for Pfizer, Sprout Pharmaceuticals, Emotional Brain and
   Strategic Science Technologies, and received speaker's fees from Pfizer.
   R.T. has served as an advisor for Lilly and Orient Europharma, and
   received speaker's fees from Lilly. J.P.M. has received grants from
   CIACT, NIH and SMSNA, and served as an advisor for Lilly, Pfizer and
   AMS. W.J.G.H. has served as an advisor for Abbvie, American Medical
   Systems, Coloplast and Pfizer. The other authors declare no competing
   interests.
CR Aghighi A, 2015, INT J IMPOT RES, V27, P63, DOI 10.1038/ijir.2014.34
   Albersen M, 2014, J UROLOGY, V191, pE526, DOI 10.1016/j.juro.2014.02.1473
   Albersen Maarten, 2013, Sex Med Rev, V1, P50, DOI 10.1002/smrj.5
   Albersen M, 2013, J SEX MED, V10, P1268, DOI 10.1111/jsm.12095
   Albersen M, 2010, EXPERT OPIN EMERG DR, V15, P467, DOI 10.1517/14728214.2010.480973
   ALTHOF SE, 1989, J SEX MARITAL THER, V15, P121
   Althof SE, 2013, J SEX MED, V10, P26, DOI [10.1111/jsm.12141, 10.1111/j.1743-6109.2012.02823.x]
   ANDERSSON KE, 1995, PHYSIOL REV, V75, P191, DOI 10.1152/physrev.1995.75.1.191
   Andric SA, 2010, BIOL REPROD, V83, P434, DOI 10.1095/biolreprod.110.083626
   Arackal Bijil Simon, 2007, Indian J Psychiatry, V49, P109, DOI 10.4103/0019-5545.33257
   Araujo AB, 1998, PSYCHOSOM MED, V60, P458, DOI 10.1097/00006842-199807000-00011
   Bacon CG, 2006, J UROLOGY, V176, P217, DOI 10.1016/S0022-5347(06)00589-1
   Bahk JY, 2010, EXP CLIN TRANSPLANT, V8, P150
   Ballard SA, 1998, J UROLOGY, V159, P2164, DOI 10.1016/S0022-5347(01)63299-3
   BALTACI S, 1995, BRIT J UROL, V76, P757, DOI 10.1111/j.1464-410X.1995.tb00769.x
   BANCROFT J, 1983, ARCH SEX BEHAV, V12, P59, DOI 10.1007/BF01542116
   Basaria S, 2015, JAMA-J AM MED ASSOC, V314, P570, DOI 10.1001/jama.2015.8881
   Baskin LS, 1997, J UROLOGY, V158, P1113, DOI 10.1016/S0022-5347(01)64400-8
   BECK JG, 1986, BEHAV RES THER, V24, P19, DOI 10.1016/0005-7967(86)90145-2
   Belardinelli R, 2005, INT J CARDIOL, V101, P83, DOI 10.1016/j.ijcard.2004.05.020
   Bianca RDD, 2006, J PHARMACOL EXP THER, V316, P703, DOI 10.1124/jpet.105.093419
   Bivalacqua TJ, 2004, P NATL ACAD SCI USA, V101, P9121, DOI 10.1073/pnas.0400520101
   Blumenthal SA, 2012, PERSPECT BIOL MED, V55, P236, DOI 10.1353/pbm.2012.0017
   Boas M, 2006, EUR J ENDOCRINOL, V154, P125, DOI 10.1530/eje.1.02066
   Boddi V, 2010, J SEX MED, V7, P2831, DOI 10.1111/j.1743-6109.2010.01887.x
   BOSSHARDT RJ, 1995, BRIT J UROL, V75, P786, DOI 10.1111/j.1464-410X.1995.tb07392.x
   Boulton AJM, 2001, DIABETOLOGIA, V44, P1296, DOI 10.1007/s001250100656
   Brackett NL, 2010, NAT REV UROL, V7, P162, DOI 10.1038/nrurol.2010.7
   BRINDLEY GS, 1983, BRIT J PSYCHIAT, V143, P332, DOI 10.1192/bjp.143.4.332
   BUENA F, 1993, FERTIL STERIL, V59, P1118
   Burnett AL, 2010, J SEX MED, V7, P3269, DOI 10.1111/j.1743-6109.2010.02025.x
   Buvat J, 2013, J SEX MED, V10, P245, DOI 10.1111/j.1743-6109.2012.02783.x
   CAMPEAU L, 1976, CIRCULATION, V54, P522, DOI 10.1161/circ.54.3.947585
   Cao S., 2004, J SEX MED, V11, P2376
   Capogrosso P, 2013, J SEX MED, V10, P1833, DOI 10.1111/jsm.12179
   Cheng JYW, 2007, INT J IMPOT RES, V19, P245, DOI 10.1038/sj.ijir.3901521
   Chew KK, 2009, J SEX MED, V6, P2340, DOI 10.1111/j.1743-6109.2009.01333.x
   Chitaley K, 2001, NAT MED, V7, P119, DOI 10.1038/83258
   Corbin JD, 2004, INT J IMPOT RES, V16, pS4, DOI 10.1038/sj.ijir.3901205
   Corona G, 2005, INT J IMPOT RES, V17, P527, DOI 10.1038/sj.ijir.3901351
   Corona G, 2013, J ENDOCRINOL INVEST, V36, P864, DOI 10.3275/8969
   Corona G, 2008, J ENDOCRINOL INVEST, V31, P799, DOI 10.1007/BF03349261
   Corona G, 2008, J SEX MED, V5, P2623, DOI 10.1111/j.1743-6109.2008.00982.x
   Corona G, 2014, J SEX MED, V11, P2065, DOI 10.1111/jsm.12601
   Corona G, 2014, ASIAN J ANDROL, V16, P581, DOI 10.4103/1008-682X.126386
   Corona G, 2014, J SEX MED, V11, P1577, DOI 10.1111/jsm.12536
   Corona G, 2013, BEST PRACT RES CL EN, V27, P581, DOI 10.1016/j.beem.2013.05.007
   Corona G, 2012, J SEX MED, V9, P1669, DOI 10.1111/j.1743-6109.2012.02717.x
   Corona G, 2010, J SEX MED, V7, P1918, DOI 10.1111/j.1743-6109.2010.01744.x
   Corona G, 2010, J SEX MED, V7, P1362, DOI 10.1111/j.1743-6109.2009.01601.x
   Corona G, 2009, J SEX MED, V6, P2591, DOI 10.1111/j.1743-6109.2009.01352.x
   Costabile RA, 1998, J UROLOGY, V160, P1325, DOI 10.1016/S0022-5347(01)62527-8
   Curran MP, 2003, DRUGS, V63, P2203, DOI 10.2165/00003495-200363200-00004
   de Boer BJ, 2005, J SEX MED, V2, P445, DOI 10.1111/j.1743-6109.2005.20364.x
   DETEJADA IS, 1989, J UROLOGY, V142, P1117, DOI 10.1016/S0022-5347(17)39009-2
   Dhar NB, 2006, J UROLOGY, V176, P2599, DOI 10.1016/j.juro.2006.08.012
   Dong JY, 2011, J AM COLL CARDIOL, V58, P1378, DOI 10.1016/j.jacc.2011.06.024
   Esposito K, 2006, INT J IMPOT RES, V18, P370, DOI 10.1038/sj.ijir.3901438
   FELDMAN HA, 1994, J UROLOGY, V151, P54, DOI 10.1016/S0022-5347(17)34871-1
   Ferrini MG, 2006, BJU INT, V97, P625, DOI 10.1111/j.1464-410X.2006.05955.x
   Ferrini MG, 2006, UROLOGY, V68, P429, DOI 10.1016/j.urology.2006.05.011
   Ferrini MG, 2009, J SEX MED, V6, P415, DOI 10.1111/j.1743-6109.2008.01105.x
   Filippi S, 2009, J SEX MED, V6, P3274, DOI 10.1111/j.1743-6109.2009.01467.x
   Finkle WD, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0085805
   Fisher WA, 2005, J SEX MED, V2, P699, DOI 10.1111/j.1743-6109.2005.00119.x
   Fisher WA, 2005, J SEX MED, V2, P675, DOI 10.1111/j.1743-6109.2005.00118.x
   Francis ME, 2007, J UROLOGY, V178, P591, DOI 10.1016/j.juro.2007.03.127
   Gacci M, 2011, EUR UROL, V60, P809, DOI 10.1016/j.eururo.2011.06.037
   Gandaglia G, 2014, EUR UROL, V65, P968, DOI 10.1016/j.eururo.2013.08.023
   Ganem JP, 1998, UROLOGY, V51, P627, DOI 10.1016/S0090-4295(97)00706-1
   Ghanem HM, 2013, J SEX MED, V10, P108, DOI 10.1111/j.1743-6109.2012.02734.x
   Giannetta E, 2012, BEST PRACT RES CL EN, V26, P539, DOI 10.1016/j.beem.2011.12.005
   Giltay EJ, 2010, J SEX MED, V7, P2572, DOI 10.1111/j.1743-6109.2010.01859.x
   Giuliano F, 2010, INT J CLIN PRACT, V64, P240, DOI 10.1111/j.1742-1241.2009.02254.x
   GIULIANO F, 1993, J NEUROENDOCRINOL, V5, P677, DOI 10.1111/j.1365-2826.1993.tb00539.x
   Glina S, 2008, J SEX MED, V5, P1791, DOI 10.1111/j.1743-6109.2008.00954.x
   Goldfarb S., 2013, Women Health, V23, P347, DOI [10.1016/B978-0-12-384978-6.00023-6, DOI 10.1016/B978-0-12-384978-6.00023-6]
   Goldstein I, 1998, NEW ENGL J MED, V338, P1397, DOI 10.1056/NEJM199805143382001
   Goldstein I, 2005, J SEX MED, V2, P819, DOI 10.1111/j.1743-6109.2005.00147.x
   Gratzke C, 2010, J UROLOGY, V184, P2197, DOI 10.1016/j.juro.2010.06.094
   Gray PB, 2005, J CLIN ENDOCR METAB, V90, P3838, DOI 10.1210/jc.2005-0247
   Grimm RH, 1997, HYPERTENSION, V29, P8, DOI 10.1161/01.HYP.29.1.8
   Guay AY, 2000, EUR UROL, V38, P671, DOI 10.1159/000020360
   Guo WB, 2010, J SEX MED, V7, P2805, DOI 10.1111/j.1743-6109.2010.01792.x
   Hackett G, 2013, J SEX MED, V10, P1612, DOI 10.1111/jsm.12146
   Hakim L, 2012, NAT REV UROL, V9, P520, DOI 10.1038/nrurol.2012.143
   HALE VE, 1990, ARCH SEX BEHAV, V19, P569, DOI 10.1007/BF01542466
   Hannan JL, 2007, J SEX MED, V4, P886, DOI 10.1111/j.1743-6109.2007.00517.x
   Hatzimouratidis K, 2007, EUR UROL, V51, P75, DOI 10.1016/j.eururo.2006.07.020
   Hatzimouratidis K, 2010, EUR UROL, V57, P804, DOI 10.1016/j.eururo.2010.02.020
   Heaton JPW, 2001, INT J IMPOT RES, V13, P317, DOI 10.1038/sj.ijir.3900760
   Hedon F, 2003, INT J IMPOT RES, V15, pS16, DOI 10.1038/sj.ijir.3900994
   Hellstrom WJG, 2010, J SEX MED, V7, P501, DOI 10.1111/j.1743-6109.2009.01626.x
   Heruti R, 2004, J SEX MED, V1, P284, DOI 10.1111/j.1743-6109.04041.x
   Huang Sharon A, 2013, P T, V38, P407
   Hull EM, 1999, BEHAV BRAIN RES, V105, P105, DOI 10.1016/S0166-4328(99)00086-8
   Isidori AM, 2015, J ENDOCRINOL INVEST, V38, P103, DOI 10.1007/s40618-014-0155-9
   Isidori AM, 2014, EUR UROL, V65, P99, DOI 10.1016/j.eururo.2013.08.048
   Jannini EA, 2014, J SEX MED, V11, P40, DOI 10.1111/jsm.12344
   Jannini EA, 2010, J SEX MED, V7, P1726, DOI 10.1111/j.1743-6109.2010.01824.x
   Jiann BP, 2013, J SEX MED, V10, P420, DOI 10.1111/j.1743-6109.2012.03007.x
   Jiann BP, 2006, INT J IMPOT RES, V18, P146, DOI 10.1038/sj.ijir.3901379
   Jin LM, 2006, FASEB J, V20, P536, DOI 10.1096/fj.05-4232fje
   Johannes CB, 2000, J UROLOGY, V163, P460, DOI 10.1016/S0022-5347(05)67900-1
   Jung J, 2010, CLIN THER, V32, P1178, DOI 10.1016/j.clinthera.2010.06.011
   Klotz T, 2005, INT J IMPOT RES, V17, P2, DOI 10.1038/sj.ijir.3901252
   Kolotkin RL, 2008, INT J IMPOT RES, V20, P487, DOI 10.1038/ijir.2008.32
   Kupelian V, 2007, EUR UROL, V52, P416, DOI 10.1016/j.eururo.2007.03.015
   Kupelian V, 2010, PREV MED, V50, P19, DOI 10.1016/j.ypmed.2009.11.006
   KWAN M, 1983, J CLIN ENDOCR METAB, V57, P557, DOI 10.1210/jcem-57-3-557
   Laumann EO, 2005, INT J IMPOT RES, V17, P39, DOI 10.1038/sj.ijir.3901250
   Leungwattanakij S, 2003, J ANDROL, V24, P239
   Levine LA, 1997, J UROLOGY, V158, P2149, DOI 10.1016/S0022-5347(01)68184-9
   Levine LA, 2001, J UROLOGY, V166, P932, DOI 10.1016/S0022-5347(05)65867-3
   Levine LA, 2001, UROL CLIN N AM, V28, P335, DOI 10.1016/S0094-0143(05)70142-7
   Liao WY, 2013, MOL BIOL REP, V40, P6729, DOI 10.1007/s11033-013-2788-8
   Lin GT, 2009, J SEX MED, V6, P320, DOI 10.1111/j.1743-6109.2008.01190.x
   Lindau ST, 2003, PERSPECT BIOL MED, V46, pS74, DOI 10.1353/pbm.2003.0055
   Lindau ST, 2011, CURR CLIN UROL, P415, DOI 10.1007/978-1-60761-916-1_28
   Linet OI, 1996, NEW ENGL J MED, V334, P873, DOI 10.1056/NEJM199604043341401
   Ludwig W, 2014, UROL INT, V92, P1, DOI 10.1159/000354931
   Lue TF, 2000, NEW ENGL J MED, V342, P1802, DOI 10.1056/NEJM200006153422407
   LUE TF, 1987, J UROLOGY, V137, P829, DOI 10.1016/S0022-5347(17)44267-4
   Lugg J, 1996, AM J PHYSIOL-ENDOC M, V271, pE354, DOI 10.1152/ajpendo.1996.271.2.E354
   Maiorino MI, 2015, ASIAN J ANDROL, V17, P5, DOI 10.4103/1008-682X.137687
   Mallis D, 2005, J UROLOGY, V174, P1913, DOI 10.1097/01.ju.0000176746.73667.3c
   Manning M, 1998, J UROLOGY, V160, P1680, DOI 10.1016/S0022-5347(01)62382-6
   Martínez-Salamanca JI, 2011, J SEX MED, V8, P1880, DOI 10.1111/j.1743-6109.2011.02281.x
   McCabe MP, 2014, J SEX MED, V11, P347, DOI 10.1111/jsm.12374
   McCullough AR, 2010, J UROLOGY, V183, P2451, DOI 10.1016/j.juro.2010.01.062
   McVary KT, 2001, J UROLOGY, V166, P1624, DOI 10.1016/S0022-5347(05)65641-8
   Melman A, 2005, EUR UROL, V48, P314, DOI 10.1016/j.eururo.2005.05.005
   Michal V, 1980, Czech Med, V3, P213
   Mills TM, 1998, BIOL REPROD, V59, P1413, DOI 10.1095/biolreprod59.6.1413
   Montague DK, 2005, J UROLOGY, V174, P230, DOI 10.1097/01.ju.0000164463.19239.19
   MONTORSI F, 1993, J UROLOGY, V150, P1819, DOI 10.1016/S0022-5347(17)35904-9
   Moreira ED, 2003, UROLOGY, V61, P431, DOI 10.1016/S0090-4295(02)02158-1
   Moreland RB, 1998, INT J IMPOT RES, V10, P113, DOI 10.1038/sj.ijir.3900328
   MORELAND RB, 1995, J UROLOGY, V153, P826, DOI 10.1016/S0022-5347(01)67730-9
   Moreland RB, 2003, INT J IMPOT RES, V15, P362, DOI 10.1038/sj.ijir.3901042
   Morelli A, 2004, ENDOCRINOLOGY, V145, P2253, DOI 10.1210/en.2003-1699
   Morgentaler A, 2014, J SEX MED, V11, P1362, DOI 10.1111/jsm.12556
   Mulhall JP, 2008, J SEX MED, V5, P1126, DOI 10.1111/j.1743-6109.2008.00794.x
   Mulhall JP, 1999, J UROLOGY, V162, P1291, DOI 10.1016/S0022-5347(05)68269-9
   Nehra A, 1996, J UROLOGY, V156, P1320, DOI 10.1016/S0022-5347(01)65578-2
   Nehra A, 2012, MAYO CLIN PROC, V87, P766, DOI 10.1016/j.mayocp.2012.06.015
   Nelson CJ, 2015, PSYCHO-ONCOLOGY, V24, P1646, DOI 10.1002/pon.3771
   Nelson CJ, 2013, J SEX MED, V10, P2559, DOI 10.1111/jsm.12271
   Nelson CJ, 2011, J SEX MED, V8, P560, DOI 10.1111/j.1743-6109.2010.02127.x
   Nichols DJ, 2002, BRIT J CLIN PHARMACO, V53, p5S, DOI 10.1046/j.0306-5251.2001.00027.x
   Nicolosi A, 2004, UROLOGY, V64, P991, DOI 10.1016/j.urology.2004.06.055
   Ohmori T, 2003, CARDIOVASC RES, V58, P170, DOI 10.1016/S0008-6363(03)00260-8
   Oudot A, 2011, EUR UROL, V60, P1020, DOI 10.1016/j.eururo.2011.07.052
   Padma-Nathan H, 2008, INT J IMPOT RES, V20, P479, DOI 10.1038/ijir.2008.33
   PadmaNathan H, 1997, NEW ENGL J MED, V336, P1, DOI 10.1056/NEJM199701023360101
   Papagiannopoulos D, 2015, ASIAN J ANDROL, V17, P11, DOI 10.4103/1008-682X.139253
   Polsky JY, 2005, BJU INT, V96, P1355, DOI 10.1111/j.1464-410X.2005.05820.x
   Porst H, 2013, J SEX MED, V10, P130, DOI 10.1111/jsm.12023
   Pourimand G, 2004, BJU INT, V94, P1310, DOI 10.1111/j.1464-410X.2004.05162.x
   PRICE DE, 1991, DIABETIC MED, V8, P964, DOI 10.1111/j.1464-5491.1991.tb01538.x
   Raina R, 2006, INT J IMPOT RES, V18, P77, DOI 10.1038/sj.ijir.3901380
   Rajpurkar A, 2003, J UROLOGY, V170, P159, DOI 10.1097/01.ju.0000072524.82345.6d
   Rastrelli G, 2014, J SEX MED, V11, P173, DOI 10.1111/jsm.12342
   Reilly CM, 1997, J ANDROL, V18, P26
   Reilly CM, 1997, J ANDROL, V18, P588
   Rosen R, 2003, EUR UROL, V44, P637, DOI 10.1016/j.eururo.2003.08.015
   Saad F, 2011, EUR J ENDOCRINOL, V165, P675, DOI 10.1530/EJE-11-0221
   Salonia A, 2012, J SEX MED, V9, P2708, DOI 10.1111/j.1743-6109.2012.02869.x
   Sanders SA, 2015, J SEX MED, V12, P1897, DOI 10.1111/jsm.12964
   Sansone A, 2014, ENDOCRINE, V46, P423, DOI 10.1007/s12020-014-0254-6
   Schmidt HM, 2014, J SEX MED, V11, P1376, DOI 10.1111/jsm.12520
   Schouten BWV, 2005, INT J IMPOT RES, V17, P58, DOI 10.1038/sj.ijir.3901264
   Schover LR, 2002, CANCER, V95, P1773, DOI 10.1002/cncr.10848
   Scott F B, 1973, Urology, V2, P80
   Seftel AD, 2013, INT J CLIN PRACT, V67, P32, DOI 10.1111/ijcp.12044
   Shabsigh R, 2005, J SEX MED, V2, P785, DOI 10.1111/j.1743-6109.2005.00139.x
   Shabsigh R, 1998, UROLOGY, V52, P848, DOI 10.1016/S0090-4295(98)00292-1
   Shabsigh R, 2005, J UROLOGY, V174, P662, DOI 10.1097/01.ju.0000165389.73148.d1
   Sharma R, 2015, EUR HEART J, V36, P2706, DOI 10.1093/eurheartj/ehv346
   Shiri R, 2007, J UROLOGY, V177, P669, DOI 10.1016/j.juro.2006.09.030
   Sikka SC, 2013, J SEX MED, V10, P120, DOI 10.1111/j.1743-6109.2012.02825.x
   Simpson D, 2003, DRUGS, V63, P2127, DOI 10.2165/00003495-200363190-00013
   Sohn M., 2006, SURG TREATMENT ERECT
   Sopko NA, 2014, NAT REV UROL, V11, P622, DOI 10.1038/nrurol.2014.278
   Stuckey BGA, 2003, DIABETES CARE, V26, P279, DOI 10.2337/diacare.26.2.279
   Sundaram CP, 1997, UROLOGY, V49, P932, DOI 10.1016/S0090-4295(97)00079-4
   Tajar A, 2010, J CLIN ENDOCR METAB, V95, P1810, DOI 10.1210/jc.2009-1796
   Tal R, 2011, J SEX MED, V8, P2370, DOI 10.1111/j.1743-6109.2011.02355.x
   Tal R, 2009, J SEX MED, V6, P2813, DOI 10.1111/j.1743-6109.2009.01437.x
   Traish AM, 1999, ENDOCRINOLOGY, V140, P1861, DOI 10.1210/en.140.4.1861
   Traish AM, 2005, J ANDROL, V26, P242
   Tran SN, 2015, INT J IMPOT RES, V27, P69, DOI 10.1038/ijir.2014.36
   Trost LW, 2013, EXPERT REV MED DEVIC, V10, P353, DOI [10.1586/ERD.12.92, 10.1586/erd.12.92]
   Trost LW, 2013, J SEX MED, V10, P84, DOI [10.1111/jsm.12115, 10.1111/jsm.12036]
   US National Library of Science, 2015, CAN FAT DER STEM CEL
   US National Library of Science, 2015, EV US LIP CELL SEP D
   US National Library of Science, 2015, SAF CLIN OUTC STUD S
   US National Library of Science, 2015, ALL HUM BON MARR DER
   US National Library of Science, 2010, MULT DOS ESC STUD 14
   US National Library of Science, 2015, EV SAF FEAS INJ PMD
   US National Library of Science, 2014, AUT AD DER STROM CEL
   US National Library of Science, 2010, CLIN PROOF CONC STUD
   US National Library of Science, 2015, SAF AUT BON MARR DER
   Vardi Y, 2004, INT J IMPOT RES, V16, P181, DOI 10.1038/sj.ijir.3901120
   Vignozzi L, 2007, J SEX MED, V4, P620, DOI 10.1111/j.1743-6109.2007.00440.x
   Vignozzi L, 2014, MOL CELL ENDOCRINOL, V384, P143, DOI 10.1016/j.mce.2014.01.014
   VIRAG R, 1981, VASCULAR SURG, V15, P9, DOI 10.1177/153857448101500102
   VIRAG R, 1991, J UROLOGY, V145, P287, DOI 10.1016/S0022-5347(17)38316-7
   Virag R., 1991, J UROLOGY, V145, P292
   Vlachopoulos CV, 2013, CIRC-CARDIOVASC QUAL, V6, P99, DOI 10.1161/CIRCOUTCOMES.112.966903
   Wang F, 2013, UROLOGY, V82, P1330, DOI 10.1016/j.urology.2013.07.061
   WEI M, 1994, AM J EPIDEMIOL, V140, P930, DOI 10.1093/oxfordjournals.aje.a117181
   Weiss J N, 1994, Int J Impot Res, V6, P171
   Wespes E, 2003, J UROLOGY, V170, P1284, DOI 10.1097/01.ju.0000086160.63566.11
   Williams G, 1998, BRIT J UROL, V81, P889
   WILSON SK, 1994, J UROLOGY, V152, P1121, DOI 10.1016/S0022-5347(17)32519-3
   Yamada T, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043673
   Yang R, 2009, BIOCHEM BIOPH RES CO, V380, P758, DOI 10.1016/j.bbrc.2009.01.144
   Yao FJ, 2013, CLIN RES CARDIOL, V102, P645, DOI 10.1007/s00392-013-0577-y
   Yiou R, 2015, EUR UROL
   Yuan JQ, 2013, EUR UROL, V63, P902, DOI 10.1016/j.eururo.2013.01.012
   Zelefsky MJ, 2014, J UROLOGY, V192, P868, DOI 10.1016/j.juro.2014.02.097
   Zermann DH, 2006, J UROLOGY, V175, P1041, DOI 10.1016/S0022-5347(05)00344-7
   Zhang XH, 2005, EUR UROL, V47, P409, DOI 10.1016/j.eururo.2004.10.021
   Zhang XH, 2011, J SEX MED, V8, P1865, DOI 10.1111/j.1743-6109.2011.02218.x
NR 225
TC 558
Z9 601
U1 9
U2 87
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2056-676X
J9 NAT REV DIS PRIMERS
JI Nat. Rev. Dis. Primers
PD FEB 4
PY 2016
VL 2
AR 16003
DI 10.1038/nrdp.2016.3
PG 20
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DT3BO
UT WOS:000381355700001
PM 27188339
OA Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Stefanaki, K
   Karagiannakis, DS
   Peppa, M
   Vryonidou, A
   Kalantaridou, S
   Goulis, DG
   Psaltopoulou, T
   Paschou, SA
AF Stefanaki, Katerina
   Karagiannakis, Dimitrios S.
   Peppa, Melpomeni
   Vryonidou, Andromachi
   Kalantaridou, Sophia
   Goulis, Dimitrios G.
   Psaltopoulou, Theodora
   Paschou, Stavroula A.
TI Food Cravings and Obesity in Women with Polycystic Ovary Syndrome:
   Pathophysiological and Therapeutic Considerations
SO NUTRIENTS
LA English
DT Review
DE polycystic ovary syndrome; obesity; food disorders; binge eating; food
   cravings
ID NUCLEUS-TRACTUS-SOLITARIUS; HORMONE-BINDING GLOBULIN; ALPHA-EXPRESSING
   CELLS; INSULIN-RESISTANCE; METABOLIC SYNDROME; INCREASED RISK; GHRELIN
   LEVELS; WEIGHT-LOSS; LUTEINIZING-HORMONE; ADOLESCENT GIRLS
AB Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women of reproductive age, constitutes a metabolic disorder frequently associated with obesity and insulin resistance (IR). Furthermore, women with PCOS often suffer from excessive anxiety and depression, elicited by low self-esteem due to obesity, acne, and hirsutism. These mood disorders are commonly associated with food cravings and binge eating. Hypothalamic signaling regulates appetite and satiety, deteriorating excessive food consumption. However, the hypothalamic function is incapable of compensating for surplus food in women with PCOS, leading to the aggravation of obesity and a vicious circle. Hyperandrogenism, IR, the reduced secretion of cholecystokinin postprandially, and leptin resistance defined by leptin receptors' knockout in the hypothalamus have been implicated in the pathogenesis of hypothalamic dysfunction and appetite dysregulation. Diet modifications, exercise, and psychological and medical interventions have been applied to alleviate food disorders, interrupting the vicious circle. Cognitive-behavioral intervention seems to be the mainstay of treatment, while the role of medical agents, such as GLP-1 analogs and naltrexone/bupropion, has emerged.
C1 [Stefanaki, Katerina; Psaltopoulou, Theodora; Paschou, Stavroula A.] Natl & Kapodistrian Univ Athens, Alexandra Hosp, Sch Med, Dept Clin Therapeut,Endocrine Unit, Athens 11527, Greece.
   [Stefanaki, Katerina; Psaltopoulou, Theodora; Paschou, Stavroula A.] Natl & Kapodistrian Univ Athens, Alexandra Hosp, Diabet Ctr, Sch Med,Dept Clin Therapeut, Athens 11527, Greece.
   [Karagiannakis, Dimitrios S.] Natl & Kapodistrian Univ Athens, Sch Med, Acad Dept Gastroenterol, Laiko Gen Hosp, Athens 11527, Greece.
   [Peppa, Melpomeni] Attikon Univ Hosp, Natl & Kapodistrian Univ Athens, Sch Med, Dept Internal Med 2,Endocrine Unit, Athens 11527, Greece.
   [Peppa, Melpomeni] Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Diabet Ctr, Sch Med,Dept Internal Med 2, Athens 11527, Greece.
   [Peppa, Melpomeni] Natl & Kapodistrian Univ Athens, Sotiria Chest Dis Hosp, Med Sch, Dept Internal Med 3, Athens 11527, Greece.
   [Vryonidou, Andromachi] Hellen Red Cross Hosp, Dept Endocrinol, Athens 11526, Greece.
   [Vryonidou, Andromachi] Hellen Red Cross Hosp, Diabet Ctr, Athens 11526, Greece.
   [Kalantaridou, Sophia] Attikon Univ Hosp, Natl & Kapodistrian Univ Athens, Sch Med, Dept Obstet & Gynecol 3, Athens 11527, Greece.
   [Goulis, Dimitrios G.] Aristotle Univ Thessaloniki, Sch Med, Dept Obstet & Gynecol 1, Unit Reprod Endocrinol, Thessaloniki 57001, Greece.
C3 Alexandra Hospital; Athens Medical School; National & Kapodistrian
   University of Athens; Alexandra Hospital; National & Kapodistrian
   University of Athens; Athens Medical School; Laiko General Hospital;
   National & Kapodistrian University of Athens; Athens Medical School;
   National & Kapodistrian University of Athens; Athens Medical School;
   University Hospital Attikon; National & Kapodistrian University of
   Athens; Athens Medical School; University Hospital Attikon; National &
   Kapodistrian University of Athens; National & Kapodistrian University of
   Athens; University Hospital Attikon; Athens Medical School; Aristotle
   University of Thessaloniki
RP Karagiannakis, DS (corresponding author), Natl & Kapodistrian Univ Athens, Sch Med, Acad Dept Gastroenterol, Laiko Gen Hosp, Athens 11527, Greece.
EM k.stefanaki@hotmail.gr; dkarag@med.uoa.gr; moly6592@yahoo.com;
   mahi_vr@hotmail.com; sophiakalantaridou@gmail.com; tpsaltop@hotmail.com;
   s.a.paschou@gmail.com
RI Goulis, Dimitrios/AAG-4589-2020; S Karagiannakis,
   Dimitrios/AFQ-7294-2022
OI Paschou, Stavroula/0000-0002-0651-1376; Peppa,
   Melpomeni/0000-0002-3538-2534; S Karagiannakis,
   Dimitrios/0000-0003-0082-634X; Goulis, Dimitrios/0000-0002-5005-1995
CR Adam TC, 2007, PHYSIOL BEHAV, V91, P449, DOI 10.1016/j.physbeh.2007.04.011
   Aguirre V, 2000, J BIOL CHEM, V275, P9047, DOI 10.1074/jbc.275.12.9047
   Ahmadian M, 2009, DIABETES, V58, P855, DOI 10.2337/db08-1644
   Annagür BB, 2015, J OBSTET GYNAECOL RE, V41, P1229, DOI 10.1111/jog.12696
   Apridonidze T, 2005, J CLIN ENDOCR METAB, V90, P1929, DOI 10.1210/jc.2004-1045
   Asarian L, 2007, ENDOCRINOLOGY, V148, P5656, DOI 10.1210/en.2007-0341
   Asdaq SMB, 2020, SAUDI J BIOL SCI, V27, P3342, DOI 10.1016/j.sjbs.2020.08.039
   Avalos Y, 2018, J NEUROENDOCRINOL, V30, DOI 10.1111/jne.12598
   Azziz R, 2016, NAT REV ENDOCRINOL, V12, P74, DOI 10.1038/nrendo.2015.230
   Baker Jessica H, 2012, Expert Rev Obstet Gynecol, V7, P573
   Balen AH, 2016, HUM REPROD UPDATE, V22, P687, DOI 10.1093/humupd/dmw025
   Bernadett Mohacsi, 2016, Psychiatr Hung, V31, P136
   Berthoud HR, 2011, CURR OPIN NEUROBIOL, V21, P888, DOI 10.1016/j.conb.2011.09.004
   Blay SL, 2016, NEUROPSYCH DIS TREAT, V12, P2895, DOI 10.2147/NDT.S91700
   Boshku AA, 2018, ACTA ENDOCRINOL-BUCH, V14, P346, DOI 10.4183/aeb.2018.346
   Brüning JC, 2000, SCIENCE, V289, P2122, DOI 10.1126/science.289.5487.2122
   Cao XH, 2014, J CLIN INVEST, V124, P4351, DOI 10.1172/JCI74726
   Carbone EA, 2021, EAT WEIGHT DISORD-ST, V26, P779, DOI 10.1007/s40519-020-00910-x
   Fuentes GC, 2020, CLIN NUTR, V39, P3092, DOI 10.1016/j.clnu.2020.01.015
   Cena H, 2020, J CLIN ENDOCR METAB, V105, pE2695, DOI 10.1210/clinem/dgaa285
   Cesta CE, 2016, PSYCHONEUROENDOCRINO, V73, P196, DOI 10.1016/j.psyneuen.2016.08.005
   Chen CI, 2015, GYNECOL ENDOCRINOL, V31, P264, DOI 10.3109/09513590.2014.984676
   Çoban ÖG, 2019, J PEDIATR ADOL GYNEC, V32, P600, DOI 10.1016/j.jpag.2019.07.008
   Colombarolli MS, 2022, EAT WEIGHT DISORD-ST, V27, P3109, DOI 10.1007/s40519-022-01437-z
   Corbould A, 2007, J ENDOCRINOL, V192, P585, DOI 10.1677/joe.1.07070
   Corkey BE, 2012, DIABETES CARE, V35, P2432, DOI 10.2337/dc12-0825
   Cortón M, 2007, J CLIN ENDOCR METAB, V92, P328, DOI 10.1210/jc.2006-1665
   Coskun EI, 2023, EUR REV MED PHARMACO, V27, P5175, DOI 10.26355/eurrev_202306_32635
   Coviello AD, 2006, J CLIN ENDOCR METAB, V91, P492, DOI 10.1210/jc.2005-1666
   Cowan S, 2023, BMC ENDOCR DISORD, V23, DOI 10.1186/s12902-022-01208-y
   Cummings DE, 2001, DIABETES, V50, P1714, DOI 10.2337/diabetes.50.8.1714
   Daghestani MH, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0839-9
   Davis SR, 2000, MENOPAUSE, V7, P395, DOI 10.1097/00042192-200011000-00005
   De Giuseppe R, 2019, NUTR DIET, V76, P560, DOI 10.1111/1747-0080.12460
   de Oliveira NM, 2023, J PHARMACOPUNCT, V26, P105, DOI 10.3831/KPI.2023.26.2.105
   DiVall SA, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0119995
   dos Santos IK, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0245023
   dos Santos IK, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000019644
   Drummen M, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00443
   DUNKEL L, 1985, J PEDIATR-US, V107, P95, DOI 10.1016/S0022-3476(85)80623-5
   Eckardt K, 2011, REV ENDOCR METAB DIS, V12, P163, DOI 10.1007/s11154-011-9168-2
   English PJ, 2002, J CLIN ENDOCR METAB, V87, P2984, DOI 10.1210/jc.87.6.2984
   Farr OM, 2016, DIABETOLOGIA, V59, P954, DOI 10.1007/s00125-016-3874-y
   Friedrichsen M, 2021, DIABETES OBES METAB, V23, P754, DOI 10.1111/dom.14280
   Fromentin G, 2012, NUTR RES REV, V25, P29, DOI 10.1017/S0954422411000175
   Fu J., 2019, Shanxi J. Tradit. Chin. Med, V40, P341
   Gannon MC, 2006, NUTR METABOLISM, V3, DOI 10.1186/1743-7075-3-16
   Garg D, 2016, INT J ENDOCRINOL, V2016, DOI 10.1155/2016/1979654
   Gautron L, 2015, CELL, V161, P133, DOI 10.1016/j.cell.2015.02.023
   Gehart H, 2010, EMBO REP, V11, P834, DOI 10.1038/embor.2010.160
   Ghaderi A, 2018, PEERJ, V6, DOI 10.7717/peerj.5113
   Giannouli A, 2023, J CLIN MED, V12, DOI 10.3390/jcm12175744
   Glueck CJ, 2011, J PEDIATR-US, V159, P308, DOI 10.1016/j.jpeds.2011.01.018
   Grilo CM, 2023, OBESITY, V31, P2762, DOI 10.1002/oby.23898
   Grilo CM, 2023, PSYCHOL MED, V53, P7775, DOI 10.1017/S0033291723001800
   Grilo CM, 2022, AM J PSYCHIAT, V179, P927, DOI 10.1176/appi.ajp.20220267
   Gu YY, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.808898
   Haeusler RA, 2018, NAT REV MOL CELL BIO, V19, P31, DOI 10.1038/nrm.2017.89
   Hahn S, 2006, EUR J ENDOCRINOL, V154, P287, DOI 10.1530/eje.1.02078
   Hickey M, 2011, HUM REPROD, V26, P1469, DOI 10.1093/humrep/der102
   Hilbert A, 2019, J CONSULT CLIN PSYCH, V87, P91, DOI 10.1037/ccp0000358
   Hirschberg AL, 2004, GYNECOL ENDOCRINOL, V19, P79, DOI 10.1080/09513590400002300
   Hollinrake E, 2007, FERTIL STERIL, V87, P1369, DOI 10.1016/j.fertnstert.2006.11.039
   Iwasa T, 2018, BEHAV BRAIN RES, V349, P102, DOI 10.1016/j.bbr.2018.02.021
   Jahromi BN, 2017, INT J REPROD BIOMED, V15, P423
   Jain A, 2007, J CLIN ENDOCR METAB, V92, P2468, DOI 10.1210/jc.2006-2274
   Jeanes YM, 2017, APPETITE, V109, P24, DOI 10.1016/j.appet.2016.11.010
   Jovanovski E, 2021, EUR J NUTR, V60, P101, DOI 10.1007/s00394-020-02224-1
   Juli Rebecca, 2023, Psychiatr Danub, V35, P217
   Kakoly NS, 2018, HUM REPROD UPDATE, V24, P455, DOI 10.1093/humupd/dmy007
   Kale-Gurbuz T, 2013, J PEDIATR ADOL GYNEC, V26, P27, DOI 10.1016/j.jpag.2012.09.002
   Kleinridders A, 2015, P NATL ACAD SCI USA, V112, P3463, DOI 10.1073/pnas.1500877112
   Koleva Daniela Iv, 2013, Folia Med (Plovdiv), V55, P25
   Krug I, 2019, NEUROPSYCH DIS TREAT, V15, P1273, DOI 10.2147/NDT.S168944
   Kuijsten A, 2015, DIABETOLOGIA, V58, P1394, DOI 10.1007/s00125-015-3585-9
   Kullmann S, 2020, LANCET DIABETES ENDO, V8, P524, DOI 10.1016/S2213-8587(20)30113-3
   Lainez NM, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01992
   le Roux CW, 2005, J CLIN ENDOCR METAB, V90, P1068, DOI 10.1210/jc.2004-1216
   Lee I, 2017, FERTIL STERIL, V107, P796, DOI 10.1016/j.fertnstert.2016.12.014
   Leidy HJ, 2015, AM J CLIN NUTR, V101, p1320S, DOI 10.3945/ajcn.114.084038
   Lewis RG, 2021, ADV EXP MED BIOL, V1344, P57, DOI 10.1007/978-3-030-81147-1_4
   Li H, 2013, ENDOCRINE, V43, P184, DOI 10.1007/s12020-012-9739-3
   Li SX, 2023, CRIT REV FOOD SCI, V63, P4351, DOI 10.1080/10408398.2021.2001429
   Lim SS, 2019, OBES REV, V20, P339, DOI 10.1111/obr.12762
   López M, 2013, TRENDS MOL MED, V19, P418, DOI 10.1016/j.molmed.2013.04.004
   Lovejoy JC, 1996, J CLIN ENDOCR METAB, V81, P2198, DOI 10.1210/jc.81.6.2198
   Makhija N, 2023, CUREUS J MED SCIENCE, V15, DOI 10.7759/cureus.37809
   Marsh CA, 2013, FERTIL STERIL, V100, P200, DOI 10.1016/j.fertnstert.2013.02.054
   Mathisen TF, 2020, INT J EAT DISORDER, V53, P574, DOI 10.1002/eat.23228
   MCCLUSKEY S, 1991, FERTIL STERIL, V55, P287
   Meex RCR, 2017, NAT REV ENDOCRINOL, V13, P508, DOI 10.1038/nrendo.2017.56
   Milutinovic DV, 2017, EXP CLIN ENDOCR DIAB, V125, P522, DOI 10.1055/s-0043-104531
   Moghetti P, 2021, J ENDOCRINOL INVEST, V44, P233, DOI 10.1007/s40618-020-01351-0
   Moran LJ, 2004, J CLIN ENDOCR METAB, V89, P3337, DOI 10.1210/jc.2003-031583
   Morgan J, 2008, INT J EAT DISORDER, V41, P427, DOI 10.1002/eat.20527
   Moroshko I, 2011, OBES REV, V12, P912, DOI 10.1111/j.1467-789X.2011.00915.x
   Mullen KL, 2007, AM J PHYSIOL-ENDOC M, V293, pE83, DOI 10.1152/ajpendo.00545.2006
   Patten RK, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.00606
   Peters KZ, 2021, TRENDS NEUROSCI, V44, P464, DOI 10.1016/j.tins.2021.02.001
   Richards Jesse, 2023, Obes Pillars, V7, P100080, DOI 10.1016/j.obpill.2023.100080
   Rojas Joselyn, 2014, Int J Reprod Med, V2014, P719050, DOI 10.1155/2014/719050
   Ruud J, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms15259
   Sáinz N, 2015, METABOLISM, V64, P35, DOI 10.1016/j.metabol.2014.10.015
   Saydam BO, 2016, CURR PHARM DESIGN, V22, P5572, DOI 10.2174/1381612822666160715143933
   Shele Grei, 2020, J Funct Morphol Kinesiol, V5, DOI 10.3390/jfmk5020035
   Shen WJ, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/6619597
   Shimobayashi M, 2018, J CLIN INVEST, V128, P1538, DOI 10.1172/JCI96139
   Sirmans SM, 2014, J INVEST MED, V62, P868, DOI 10.1097/01.JIM.0000446834.90599.5d
   Sohn JW, 2013, TRENDS NEUROSCI, V36, P504, DOI 10.1016/j.tins.2013.05.003
   Soydinc E, 2013, EUR REV MED PHARMACO, V17, P2111
   Stefanaki K, 2023, HORM-INT J ENDOCRINO, V22, P715, DOI 10.1007/s42000-023-00487-x
   Stefanaki K, 2023, ENDOCRINE, V82, P201, DOI 10.1007/s12020-023-03436-1
   Tay CT, 2019, FERTIL STERIL, V112, P353, DOI 10.1016/j.fertnstert.2019.03.027
   Teede H, 2010, BMC MED, V8, DOI 10.1186/1741-7015-8-41
   Teede HJ, 2018, HUM REPROD, V33, P1602, DOI 10.1093/humrep/dey256
   Thammacharoen S, 2008, ENDOCRINOLOGY, V149, P1609, DOI 10.1210/en.2007-0340
   Thomas J, 2014, PSYCHONEUROENDOCRINO, V50, P167, DOI 10.1016/j.psyneuen.2014.08.012
   Tiwari S, 2007, J AM SOC NEPHROL, V18, P2661, DOI 10.1681/ASN.2006121410
   Treasure J, 2020, LANCET, V395, P899, DOI 10.1016/S0140-6736(20)30059-3
   Tronieri JS, 2020, INT J OBESITY, V44, P353, DOI 10.1038/s41366-019-0348-6
   Valdearcos M, 2018, CELL METAB, V27, P1356, DOI 10.1016/j.cmet.2018.04.019
   Wang YL, 2021, GYNECOL ENDOCRINOL, V37, P1072, DOI 10.1080/09513590.2021.1942452
   Watson NA, 2018, NUTR RES, V57, P56, DOI 10.1016/j.nutres.2018.05.005
   Williams KW, 2012, NAT NEUROSCI, V15, P1350, DOI 10.1038/nn.3217
   Wylie J., 2009, J. Hum. Nutr. Diet, V22, P274, DOI [10.1111/j.1365-277X.2009.00952_25.x, DOI 10.1111/J.1365-277X.2009.00952_25.X, DOI 10.1111/JHN.2009.22.ISSUE-3]
   Xu YL, 2022, J HEALTHC ENG, V2022, DOI 10.1155/2022/9240569
   Yeo GSH, 2012, NAT NEUROSCI, V15, P1343, DOI 10.1038/nn.3211
   Zhang GQ, 2000, ENDOCRINOLOGY, V141, P2735, DOI 10.1210/en.141.8.2735
   Zhao H, 2023, J OVARIAN RES, V16, DOI 10.1186/s13048-022-01091-0
   Zhao R.N., 2019, Acad. J. Shanghai Univ. Tradit. Chin. Med, V33, P27
NR 130
TC 2
Z9 2
U1 4
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2024
VL 16
IS 7
AR 1049
DI 10.3390/nu16071049
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA NN7X2
UT WOS:001201205700001
PM 38613082
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, M
   Paik, JK
   Kang, R
   Kim, SY
   Lee, SH
   Lee, JH
AF Kim, Minjoo
   Paik, Jean Kyung
   Kang, Ryungwoo
   Kim, Soo Young
   Lee, Sang-Hyun
   Lee, Jong Ho
TI Increased oxidative stress in normal-weight postmenopausal women with
   metabolic syndrome compared with metabolically healthy overweight/obese
   individuals
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Metabolic syndrome; Weight; Postmenopausal women; Oxidative stress
ID LOW-DENSITY-LIPOPROTEIN; CHRONIC KIDNEY-DISEASE; C-REACTIVE PROTEIN;
   INSULIN-RESISTANCE; OBESE; INFLAMMATION; RISK; PHENOTYPES; MEN;
   POPULATION
AB Objective. The purpose of this study was to assess whether the metabolically healthy overweight/obese phenotype is associated with decreased oxidative stress compared with normal-weight individuals with metabolic syndrome (MetS).
   Materials/Methods. Plasma oxidized LDL (ox-LDL) and urinary 8-epi-prostaglandin F-2 alpha (8-epi-PGF(2 alpha)) were analyzed in a cross-sectional study of 1846 healthy postmenopausal women. Participants were classified by presence (n=569) or absence (n=1277) of MetS and by BMI (18.5-24.9 kg/m(2)=normal weight, n=1254; >= 25 kg/m(2)=overweight/obese, n=592). MetS was diagnosed with the modified National Cholesterol Education Program Adult Treatment Panel III criteria.
   Results. Compared to normal weight women with MetS (n=296), metabolically healthy overweight/obese women (n=319) showed lower blood pressure, triglyceride, and glucose and higher HDL cholesterol, adiponectin, and LDL particle size. Ox-LDL was higher in overweight/obese women without MetS than in normal weight women without MetS (n=958) but was lower than in women with MetS. Urinary 8-epi-PGF(2 alpha) level was about 11% lower in women without MetS than in women with MetS. Normal weight women with MetS had greater odds of having ox-LDL (multivariate odds ratio [OR] 2.42, 95% CI: 1.65-3.55) and 8-epi-PGF(2 alpha) (OR 1.49; CI: 1.03-2.14) levels in the top quartile compared to normal weight women without MetS after adjusting for age, drinking, smoking, total- and LDL-cholesterol, and high sensitivity C-reactive protein. Additionally, there was no significant correlation between ox-LDL and 8-epi-PGF(2 alpha).
   Conclusions. The metabolically healthy overweight/obese phenotype was associated with a better overall metabolic profile and less oxidative stress than that observed in normal weight individuals with MetS. Furthermore, there was a lack of association between ox-LDL and 8-epi-PGF(2 alpha). (C) 2013 Elsevier Inc. All rights reserved.
C1 [Kim, Minjoo; Kang, Ryungwoo; Lee, Jong Ho] Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, Natl Leading Res Lab Clin Nutrigenet Nutrigen, Seoul 120749, South Korea.
   [Kim, Minjoo; Kang, Ryungwoo; Lee, Jong Ho] Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, Brain Korea Project 21, Seoul 120749, South Korea.
   [Paik, Jean Kyung; Lee, Jong Ho] Yonsei Univ, Res Inst Sci Aging, Seoul 120749, South Korea.
   [Kim, Soo Young] Yonsei Univ, Interdisciplinary Course Sci Aging, Seoul 120749, South Korea.
   [Lee, Sang-Hyun] Natl Hlth Insurance Corp Ilsan Hosp, Dept Family Practice, Goyang Si, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University; Yonsei
   University
RP Lee, JH (corresponding author), Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, 134 Shinchon Dong, Seoul 120749, South Korea.
EM jhleeb@yonsei.ac.kr
RI Kim, Minjoo/AEN-5516-2022; Kang, Hyun-Seung/J-5365-2012
FU Korean National Health Insurance Corporation; National Research
   Foundation of Korea, Republic of Korea [M10642120002-06N4212-00210,
   2012-0005604, 2012M3A9C4048762]; National Research Foundation of Korea
   [2012M3A9C4048762] Funding Source: Korea Institute of Science &
   Technology Information (KISTI), National Science & Technology
   Information Service (NTIS)
FX We would like to thank all study participants. This work was supported
   by the Korean National Health Insurance Corporation and the Mid-career
   Researcher Program through National Research Foundation of Korea
   (M10642120002-06N4212-00210, 2012-0005604, and 2012M3A9C4048762),
   Republic of Korea.
CR Barinas-Mitchell E, 2001, AM J EPIDEMIOL, V153, P1094, DOI 10.1093/aje/153.11.1094
   Basu S, 2004, FREE RADICAL RES, V38, P105, DOI 10.1080/10715760310001646895
   Beydoun HA, 2012, MATURITAS, V71, P55, DOI 10.1016/j.maturitas.2011.10.010
   Brochu M, 2001, J CLIN ENDOCR METAB, V86, P1020, DOI 10.1210/jc.86.3.1020
   Brown Michele A, 2007, Ultrasound Q, V23, P233, DOI 10.1097/ruq.0b013e318159927f
   Calori G, 2011, DIABETES CARE, V34, P210, DOI 10.2337/dc10-0665
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Conus F, 2007, APPL PHYSIOL NUTR ME, V32, P4, DOI 10.1139/h06-092
   Davì G, 2002, JAMA-J AM MED ASSOC, V288, P2008, DOI 10.1001/jama.288.16.2008
   Dunaif A, 2008, NAT CLIN PRACT ENDOC, V4, P272, DOI 10.1038/ncpendmet0787
   Evans JL, 2002, ENDOCR REV, V23, P599, DOI 10.1210/er.2001-0039
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Holvoet P, 2004, DIABETES, V53, P1068, DOI 10.2337/diabetes.53.4.1068
   Hulthe J, 2001, CLIN SCI, V100, P371, DOI [10.1042/CS20000269, 10.1042/cs1000371]
   Karelis AD, 2004, DIABETES OBES METAB, V6, P456, DOI 10.1111/j.1462-8902.2004.00377.x
   Kurella M, 2005, J AM SOC NEPHROL, V16, P2134, DOI 10.1681/ASN.2005010106
   Liedtke S, 2012, OBESITY, V20, P1088, DOI 10.1038/oby.2011.383
   Moran C, 2003, FERTIL STERIL, V80, P1466, DOI 10.1016/j.fertnstert.2003.05.010
   Mueller CFH, 2005, ARTERIOSCL THROM VAS, V25, P274, DOI 10.1161/01.ATV.0000149143.04821.eb
   Paik JK, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0029675
   Pajunen P, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-754
   Pickup JC, 2004, DIABETES CARE, V27, P813, DOI 10.2337/diacare.27.3.813
   Rains JL, 2011, FREE RADICAL BIO MED, V50, P567, DOI 10.1016/j.freeradbiomed.2010.12.006
   Reaven GM, 1996, NEW ENGL J MED, V334, P374, DOI 10.1056/NEJM199602083340607
   Ruderman N, 1998, DIABETES, V47, P699, DOI 10.2337/diabetes.47.5.699
   Sigurdardottir V, 2002, J INTERN MED, V252, P440, DOI 10.1046/j.1365-2796.2002.01054.x
   Sjogren P, 2005, ARTERIOSCL THROM VAS, V25, P2580, DOI 10.1161/01.ATV.0000190675.08857.3d
   Tan CE, 2004, DIABETES CARE, V27, P1182, DOI 10.2337/diacare.27.5.1182
   Thethi T, 2012, CURR HYPERTENS REP, V14, P160, DOI 10.1007/s11906-012-0245-z
   Wildman RP, 2008, ARCH INTERN MED, V168, P1617, DOI 10.1001/archinte.168.15.1617
   Wildman RP, 2011, OBESITY, V19, P1482, DOI 10.1038/oby.2010.332
   Yudkin JS, 2000, ATHEROSCLEROSIS, V148, P209, DOI 10.1016/S0021-9150(99)00463-3
NR 33
TC 50
Z9 54
U1 0
U2 7
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD APR
PY 2013
VL 62
IS 4
BP 554
EP 560
DI 10.1016/j.metabol.2012.10.006
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 125HL
UT WOS:000317530800011
PM 23142163
DA 2025-06-11
ER

PT J
AU Russo, E
   Viazzi, F
   Pontremoli, R
   Angeli, F
   Barbagallo, CM
   Berardino, B
   Bombelli, M
   Cappelli, F
   Casiglia, E
   Cianci, R
   Ciccarelli, M
   Cicero, AFG
   Cirillo, M
   Cirillo, P
   D'Elia, L
   Desideri, G
   Ferri, C
   Galletti, F
   Gesualdo, L
   Giannattasio, C
   Grassi, G
   Iaccarino, G
   Imbalzano, E
   Lippa, L
   Mallamaci, F
   Maloberti, A
   Masi, S
   Masulli, M
   Mazza, A
   Mengozzi, A
   Muiesan, ML
   Nazzaro, P
   Palatini, P
   Parati, G
   Quarti-Trevano, F
   Rattazzi, M
   Reboldi, G
   Rivasi, G
   Salvetti, M
   Tikhonoff, V
   Tocci, G
   Ungar, A
   Verdecchia, P
   Virdis, A
   Volpe, M
   Borghi, C
AF Russo, Elisa
   Viazzi, Francesca
   Pontremoli, Roberto
   Angeli, Fabio
   Barbagallo, Carlo Maria
   Berardino, Bruno
   Bombelli, Michele
   Cappelli, Federica
   Casiglia, Edoardo
   Cianci, Rosario
   Ciccarelli, Michele
   Cicero, Arrigo F. G.
   Cirillo, Massimo
   Cirillo, Pietro
   D'Elia, Lanfranco
   Desideri, Giovambattista
   Ferri, Claudio
   Galletti, Ferruccio
   Gesualdo, Loreto
   Giannattasio, Cristina
   Grassi, Guido
   Iaccarino, Guido
   Imbalzano, Egidio
   Lippa, Luciano
   Mallamaci, Francesca
   Maloberti, Alessandro
   Masi, Stefano
   Masulli, Maria
   Mazza, Alberto
   Mengozzi, Alessandro
   Muiesan, Maria Lorenza
   Nazzaro, Pietro
   Palatini, Paolo
   Parati, Gianfranco
   Quarti-Trevano, Fosca
   Rattazzi, Marcello
   Reboldi, Gianpaolo
   Rivasi, Giulia
   Salvetti, Massimo
   Tikhonoff, Valerie
   Tocci, Giuliano
   Ungar, Andrea
   Verdecchia, Paolo
   Virdis, Agostino
   Volpe, Massimo
   Borghi, Claudio
CA Italian Soc Hypertension SIIA
TI Predictive value of TG/HDL-C and GFR-adjusted uric acid levels on
   cardiovascular mortality: the URRAH study
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE TG/HDL-C ratio; Triglycerides; Insulin-resistance; Uric acid; Kidney
   function; Cardiovascular mortality
ID CHRONIC KIDNEY-DISEASE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   CHOLESTEROL RATIO; CARDIOMETABOLIC RISK; ARTERIAL STIFFNESS; OXIDATIVE
   STRESS; TRIGLYCERIDE; PROGRESSION; OUTCOMES
AB BackgroundInsulin resistance (IR) and serum uric acid (SUA) are closely interconnected: SUA contributes to adversely affects the insulin signaling pathway and contributes to IR, while IR is a known predictor for the development of hyperuricemia. The triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio has been proposed as an easily obtainable marker for IR. This research aimed to investigate the interaction between IR and glomerular filtration rate (GFR)-adjusted uricemia (SUA/GFR ratio) in determining CV risk in a large population cohort study.MethodsData from 18,694 subjects were analyzed from Uric acid Right foR heArt Healt (URRAH) database. The study evaluated the association between TG/HDL-C ratio and SUA/GFR ratio, as well as their impact on the development of outcomes during the follow-up study period. The primary endpoint was CV mortality.ResultsAfter a mean follow-up of 124 +/- 64 months, 2,665 (14.2%) CV deaths occurred. The incidence of fatal and non-fatal CV events increased in parallel with the increase of TG/HDL-C quintiles. TG/HDL-C ratio showed a positive association with increasing of SUA/GFR ratio, even in non-diabetic patients. Multivariate analysis showed that the TG/HDL-C ratio increases the mortality risk even after adjustment for potential confounding factors. Finally, IR and GFR-adjusted hyperuricemia showed an additive effect on CV mortality.ConclusionsBoth IR and SUA/GFR ratio independently predict CV mortality, regardless of age, gender, BMI, diabetes, hypertension and statin use. The joint effect of the TG/HDL-C ratio and the elevated SUA/GFR ratio was greater than the presence of each single risk factor on CV mortality. This highlights the importance of monitoring these markers to better assess cardiovascular risk.
C1 [Russo, Elisa; Viazzi, Francesca; Pontremoli, Roberto] Univ Genoa, Dipartimento Med Interna & Special Med, Genoa, Liguria, Italy.
   [Russo, Elisa; Viazzi, Francesca; Pontremoli, Roberto] IRCCS Osped Policlin San Martino, Genoa, Liguria, Italy.
   [Angeli, Fabio] Univ Insubria, Varese, Lombardy, Italy.
   [Angeli, Fabio] Ist Clin Sci Maugeri SpA IRCCS Tradate, Tradate, Lombardy, Italy.
   [Barbagallo, Carlo Maria] Univ Palermo, Dipartimento Promoz Salute Maternoinfantile Med I, Palermo, Italy.
   [Berardino, Bruno; Ferri, Claudio] Univ Aquila, Dipartimento Med Clin Sanita Pubbl Sci Vita & Amb, Laquila, Abruzzo, Italy.
   [Bombelli, Michele] Univ Milano Bicocca, Dipartimento Med & Chirurg, Milan, Lombardy, Italy.
   [Cappelli, Federica; Masi, Stefano; Mengozzi, Alessandro; Virdis, Agostino] Univ Pisa, Dipartimento Med Clin & Sperimentale, Pisa, Tuscany, Italy.
   [Casiglia, Edoardo; Palatini, Paolo; Tikhonoff, Valerie] Univ Padua, Dipartimento Med, Padua, Veneto, Italy.
   [Cianci, Rosario] Univ Roma La Sapienza, Dipartimento Med Traslaz & Precis, Rome, Lazio, Italy.
   [Ciccarelli, Michele] Univ Salerno, Dipartimento Med Chirurg & Odontoiatria, Scuola Med Salernitana, Baronissi, Campania, Italy.
   [Cicero, Arrigo F. G.; Borghi, Claudio] Univ Bologna, Dipartimento Sci Med & Chirurg, Bologna, Emilia Romagna, Italy.
   [Borghi, Claudio] IRCCS Azienda Osped Univ Bologna, Dipartimento Malattie Cardiotoraco Vasc, Policlin St Orsola, Bologna, Emilia Romagna, Italy.
   [Cirillo, Massimo] Univ Salerno, Dipartimento Med Chirurg & Odontoiatria, Scuola Med Salernitana, Salerno, Campania, Italy.
   [Cirillo, Pietro; Gesualdo, Loreto] Univ Bari Aldo Moro, Dipartimento Emergenza & Trapianti Organi, Bari, Italy.
   [D'Elia, Lanfranco; Galletti, Ferruccio; Iaccarino, Guido; Masulli, Maria] Univ Napoli Federico II, Dipartimento Med Clin & Chirurg, Naples, Campania, Italy.
   [Desideri, Giovambattista] Univ Roma Sapienza, Dipartimento Sci Clin Internist Anestesiol & Card, Rome, Lazio, Italy.
   [Giannattasio, Cristina; Maloberti, Alessandro] ASST Grande Osped Metropolitano Niguarda De Gaspe, Cardio Ctr, Milan, Lombardy, Italy.
   [Giannattasio, Cristina; Grassi, Guido; Maloberti, Alessandro; Quarti-Trevano, Fosca] Univ Milano Bicocca, Scuola Med & Chirurg, Monza, Lombardy, Italy.
   [Imbalzano, Egidio] Univ Messina, Dipartimento Med Clin & Sperimentale, Messina, Sicily, Italy.
   [Lippa, Luciano] Soc Italiana Med Med Gen, Avezzano, Abruzzo, Italy.
   [Mallamaci, Francesca] Azienda Osped Bianchi Melacrino Morelli, Calabria, Italy.
   [Mallamaci, Francesca] CNR, Ist Fisiol Clin, Sez Reggio Calabria, Calabria, Italy.
   [Mazza, Alberto] Osped S Maria Misericordia, Rovigo, Veneto, Italy.
   [Muiesan, Maria Lorenza; Salvetti, Massimo] Univ Brescia, Dipartimento Sci Clin & Sperimentali, Brescia, Lombardy, Italy.
   [Nazzaro, Pietro] Univ Bari Aldo Moro, Dipartimento Med Precis & Rigenerat, Bari, Apulia, Italy.
   [Nazzaro, Pietro] Univ Bari Aldo Moro, Area Jon, Bari, Apulia, Italy.
   [Parati, Gianfranco] Ist Auxol Italiano, Ist Sci San Luca, Milan, Lombardy, Italy.
   [Parati, Gianfranco] Univ Milano Bicocca, Milan, Lombardy, Italy.
   [Rattazzi, Marcello] Ca Foncello Univ Padua, Dept Med DIMED, Med Interna 1, Treviso, Veneto, Italy.
   [Reboldi, Gianpaolo] Univ Perugia, Dipartimento Med & Chirurg, Perugia, Italy.
   [Tocci, Giuliano; Volpe, Massimo] Univ Roma La Sapienza, Dipartimento Med Clin & Mol, Rome, Lazio, Italy.
   [Tocci, Giuliano] Azienda Osped St Andrea, Dipartimento Sci Med, Rome, Lazio, Italy.
   [Verdecchia, Paolo] Azienda Osped Perugia, Perugia, Umbria, Italy.
   [Volpe, Massimo] IRCCS San Raffaele, Rome, Lazio, Italy.
C3 University of Genoa; University of Genoa; IRCCS AOU San Martino IST;
   University of Insubria; University of Palermo; University of L'Aquila;
   University of Milano-Bicocca; University of Pisa; University of Padua;
   Sapienza University Rome; University of Salerno; University of Bologna;
   IRCCS Azienda Ospedaliero-Universitaria di Bologna; University of
   Salerno; Universita degli Studi di Bari Aldo Moro; University of Naples
   Federico II; Sapienza University Rome; University of Milano-Bicocca;
   University of Messina; Consiglio Nazionale delle Ricerche (CNR);
   Hospital Santa Maria della Misericordia; University of Brescia;
   Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro; IRCCS Istituto Auxologico Italiano; University of
   Milano-Bicocca; University of Perugia; Sapienza University Rome;
   Sapienza University Rome; Azienda Ospedaliera Sant'Andrea; University of
   Perugia; Azienda Ospedaliera di Perugia; IRCCS San Raffaele Pisana;
   Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele
RP Viazzi, F (corresponding author), Univ Genoa, Dipartimento Med Interna & Special Med, Genoa, Liguria, Italy.; Viazzi, F (corresponding author), IRCCS Osped Policlin San Martino, Genoa, Liguria, Italy.
EM francesca.viazzi@unige.it
RI Viazzi, Francesca/AAB-2479-2019; Imbalzano, Egidio/A-2063-2015;
   Maloberti, Alessandro/Q-1244-2017; Rivasi, Giulia/ISB-2204-2023; Russo,
   Elisa/AAH-2246-2021; Tikhonoff, Valerie/AAC-3728-2019; Cianci,
   Rosario/AAS-7708-2020; Mengozzi, Alessandro/JSK-7085-2023; Tocci,
   Giuliano/K-4901-2018; Muiesan, M.L./AAC-2060-2022; Cicero,
   Arrigo/H-8244-2019; Rattazzi, Marcello/AAP-6251-2020; Cirillo,
   Pietro/HPE-7114-2023; D'Elia, Lanfranco/U-6499-2017; Cirillo,
   Massimo/G-5480-2018
OI Cicero, Arrigo Francesco Giuseppe/0000-0002-4367-3884; Tikhonoff,
   Valerie/0000-0001-7846-0101; Cirillo, Massimo/0000-0002-6409-3504
FU Fondazione of the Italian Society of Hypertension
FX This work has been conducted with an unrestricted grant from the
   Fondazione of the Italian Society of Hypertension (grant: MIOL).
CR Acevedo-Fernández M, 2023, NUTR METAB CARDIOVAS, V33, P1725, DOI 10.1016/j.numecd.2023.05.023
   Ambrosio G, 2021, EUR J INTERN MED, V89, P65, DOI 10.1016/j.ejim.2021.04.001
   Artunc F, 2016, NAT REV NEPHROL, V12, P721, DOI 10.1038/nrneph.2016.145
   Ausk KJ, 2010, DIABETES CARE, V33, P1179, DOI 10.2337/dc09-2110
   Baneu P, 2024, BIOMEDICINES, V12, DOI 10.3390/biomedicines12071493
   Baral Sushil, 2023, J Nepal Health Res Counc, V21, P271, DOI 10.33314/jnhrc.v21i02.4565
   Cao TR, 2023, NUTR METAB CARDIOVAS, V33, P1339, DOI 10.1016/j.numecd.2023.05.004
   Che BZ, 2023, CARDIOVASC DIABETOL, V22, DOI 10.1186/s12933-023-01762-2
   Chen JQ, 2023, CARDIOVASC DIABETOL, V22, DOI 10.1186/s12933-023-02054-5
   Chen L, 2022, DIABET METAB SYND OB, V15, P3693, DOI 10.2147/DMSO.S387426
   Chen WY, 2022, ENDOCRINE, V76, P62, DOI 10.1007/s12020-022-02979-z
   Choi J, 2023, PLOS ONE, V18, DOI 10.1371/journal.pone.0288666
   Chu SY, 2019, ANN PEDIATR ENDOCRIN, V24, P41, DOI 10.6065/apem.2019.24.1.41
   Copur S, 2022, EUR J INTERN MED, V103, P4, DOI 10.1016/j.ejim.2022.04.022
   Corry DB, 2008, J HYPERTENS, V26, P269, DOI 10.1097/HJH.0b013e3282f240bf
   Cui KY, 2023, J AM HEART ASSOC, V12, DOI 10.1161/JAHA.123.030625
   D'Elia L, 2024, METABOLITES, V14, DOI 10.3390/metabo14030164
   D'Elia L, 2024, J CLIN ENDOCR METAB, V110, pe470, DOI 10.1210/clinem/dgae170
   de Giorgis T, 2014, EUR J ENDOCRINOL, V170, P173, DOI 10.1530/EJE-13-0452
   Desideri G, 2018, HIGH BLOOD PRESS CAR, V25, P197, DOI 10.1007/s40292-018-0250-7
   Di Bonito P, 2012, DIABETES CARE, V35, P158, DOI 10.2337/dc11-1456
   Du TT, 2014, CARDIOVASC DIABETOL, V13, DOI 10.1186/s12933-014-0146-3
   Eknoyan G, 2002, AM J KIDNEY DIS, V39, pS14, DOI 10.1053/ajkd.2002.30939
   Fan YJ, 2024, DIABETES METAB J, V48, P19, DOI 10.4093/dmj.2023.0110
   Feig DI, 2008, NEW ENGL J MED, V359, P1811, DOI 10.1056/NEJMra0800885
   Genovesi S, 2022, FRONT CARDIOVASC MED, V9, DOI 10.3389/fcvm.2022.978366
   Heerkens L, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1240099
   Huang LH, 2023, FRONT CARDIOVASC MED, V10, DOI 10.3389/fcvm.2023.1165338
   Johnson Richard J, 2015, Curr Med Res Opin, V31 Suppl 2, P3, DOI 10.1185/03007995.2015.1087979
   Johnson RJ, 2013, NEPHROL DIAL TRANSPL, V28, P2221, DOI 10.1093/ndt/gft029
   Kataria A, 2015, NAT REV NEPHROL, V11, P610, DOI 10.1038/nrneph.2015.94
   Kawamoto R, 2019, METAB SYNDR RELAT D, V17, P81, DOI 10.1089/met.2018.0055
   Kirça M, 2017, J RECEPT SIG TRANSD, V37, P167, DOI 10.1080/10799893.2016.1203941
   Kosmas CE, 2023, DIAGNOSTICS, V13, DOI 10.3390/diagnostics13050929
   Kurella M, 2005, J AM SOC NEPHROL, V16, P2134, DOI 10.1681/ASN.2005010106
   Levey AS, 2009, ANN INTERN MED, V150, P604, DOI 10.7326/0003-4819-150-9-200905050-00006
   Liu F, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-01211-z
   Liu X, 2022, CARDIOVASC DIABETOL, V21, DOI 10.1186/s12933-022-01546-0
   Maloberti A, 2024, NUTR METAB CARDIOVAS, V34, P223, DOI 10.1016/j.numecd.2023.10.009
   Matsushita K, 2015, LANCET DIABETES ENDO, V3, P514, DOI 10.1016/S2213-8587(15)00040-6
   Mengozzi A, 2023, METABOLITES, V13, DOI 10.3390/metabo13020244
   Murguía-Romero M, 2013, J LIPID RES, V54, P2795, DOI 10.1194/jlr.M040584
   Nguyen H, 2022, PATHOPHYSIOLOGY-BASE, V29, P374, DOI 10.3390/pathophysiology29030029
   Okosun IS, 2020, DIABETES METAB SYND, V14, P3, DOI 10.1016/j.dsx.2019.11.012
   Ormazabal V, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0762-4
   Ouyang R, 2022, MOL MED REP, V25, DOI 10.3892/mmr.2021.12551
   Patil S, 2020, AM J CARDIOVASC DIS, V10, P241
   Penno G, 2021, BMC MED, V19, DOI 10.1186/s12916-021-01936-3
   Raikou VD, 2020, J CARDIOVASC DEV DIS, V7, DOI 10.3390/jcdd7030028
   Ramírez AJ, 2018, CURR HYPERTENS REV, V14, P154, DOI 10.2174/1573402114666180413143312
   Ricardo AC, 2015, AM J KIDNEY DIS, V65, P412, DOI 10.1053/j.ajkd.2014.09.016
   Russo E, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24032960
   Russo E, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.713652
   Russo E, 2022, J NEPHROL, V35, P211, DOI 10.1007/s40620-021-00985-4
   Saito Y, 2021, J CARDIOL, V78, P51, DOI 10.1016/j.jjcc.2020.12.013
   Salazar MR, 2017, NUTR METAB CARDIOVAS, V27, P366, DOI 10.1016/j.numecd.2016.12.002
   Shu J, 2023, PREV MED REP, V36, DOI 10.1016/j.pmedr.2023.102520
   Thomas G, 2011, CLIN J AM SOC NEPHRO, V6, P2364, DOI 10.2215/CJN.02180311
   Viazzi F, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0176058
   Virdis A, 2020, HYPERTENSION, V75, P302, DOI 10.1161/HYPERTENSIONAHA.119.13643
   Vyssoulis GP, 2010, INT J CARDIOL, V138, P119, DOI 10.1016/j.ijcard.2008.08.005
   Watt NT, 2017, DIABETES, V66, P2808, DOI 10.2337/db17-0062
   Whaley-Connell A, 2018, CARDIORENAL MED, V8, P41, DOI 10.1159/000479801
   Wu ZY, 2021, CARDIOVASC DIABETOL, V20, DOI 10.1186/s12933-021-01330-6
   Xi XQ, 2024, TEX HEART I J, V51, DOI 10.14503/THIJ-23-8210
   Xiao DR, 2024, DIABETES-METAB RES, V40, DOI 10.1002/dmrr.3764
   Xu FF, 2024, INT J ENDOCRINOL, V2024, DOI 10.1155/2024/4002839
   Xu J, 2024, ANN MED, V56, DOI 10.1080/07853890.2024.2357224
   Yang Y, 2023, FRONT CARDIOVASC MED, V10, DOI 10.3389/fcvm.2023.1226108
   Zhang XH, 2017, BIOSCIENCE REP, V37, DOI 10.1042/BSR20170947
   Zhang YL, 2022, NUTRIENTS, V14, DOI 10.3390/nu14173525
NR 71
TC 0
Z9 0
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD JAN 24
PY 2025
VL 24
IS 1
AR 21
DI 10.1186/s12944-025-02440-w
PG 11
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA T6J7M
UT WOS:001406049000001
PM 39856749
OA gold
DA 2025-06-11
ER

PT J
AU Krishnan, S
   Gertz, ER
   Adams, SH
   Newman, JW
   Pedersen, TL
   Keim, NL
   Bennett, BJ
AF Krishnan, Sridevi
   Gertz, Erik R.
   Adams, Sean H.
   Newman, John W.
   Pedersen, Theresa L.
   Keim, Nancy L.
   Bennett, Brian J.
TI Effects of a diet based on the Dietary Guidelines on vascular health and
   TMAO in women with cardiometabolic risk factors
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Dietary guidelines diet pattern; Endothelial dysfunction; Controlled
   feeding trial
ID TRIMETHYLAMINE-N-OXIDE; ENDOTHELIAL FUNCTION; METABOLIC SYNDROME;
   L-CARNITINE; CARDIOVASCULAR RISK; OXIDATIVE STRESS; GUT MICROBIOTA;
   DYSFUNCTION; CHOLINE; INFLAMMATION
AB Background and aims: Recent evidence links trimethylamine oxide (TMAO) to endothelial dysfunction, an early indicator of cardiovascular disease. We aimed to determine whether short-term consumption of a diet patterned after the 2010 Dietary Guidelines for Americans (DGA) would affect endothelial function, plasma TMAO concentrations, and cardiovascular disease risk, differently than a typical American Diet (TAD). Methods and results: An 8-wk controlled feeding trial was conducted in overweight/obese women pre-screened for insulin resistance and/or dyslipidemia. Women were randomized to a DGA or TAD group (n = 22/group). At wk0 (pre-intervention) and wk8 (post-intervention) vascular age was calculated; endothelial function (reactive hyperemia index (RHI)) and augmentation index (AI@75) were measured using EndoPAT, and plasma TMAO was measured by LC-MS/ MS. Vascular age was reduced in DGA at wk8 compared to wk0 but TAD wk8 was not different from wk0 (DGA wk0: 54.2 +/- 4.0 vs. wk8: 50.5 +/- 3.1 (p = 0.05), vs. TAD wk8: 47.7 +/- 2.3). Plasma TMAO concentrations, RHI, and AI@75 were not different between groups or weeks. Conclusion: Consumption of a diet based on the 2010 Dietary Guidelines for Americans for 8 weeks did not improve endothelial function or reduce plasma TMAO. Clinicaltrials.gov: NCT02298725. Published by Elsevier B.V. on behalf of The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. This is an open access article under the CC BY-NC ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Krishnan, Sridevi; Gertz, Erik R.; Newman, John W.; Keim, Nancy L.; Bennett, Brian J.] USDA, Western Human Nutr Res Ctr, Davis, CA 95616 USA.
   [Krishnan, Sridevi; Newman, John W.; Keim, Nancy L.; Bennett, Brian J.] Univ Calif Davis, Dept Nutr, Davis, CA USA.
   [Adams, Sean H.] Univ Calif Davis, Dept Surg, Sch Med, Sacramento, CA USA.
   [Adams, Sean H.] Univ Calif Davis, Sch Med, Ctr Alimentary & Metab Sci, Sacramento, CA 95817 USA.
   [Pedersen, Theresa L.] Univ Calif Davis, Dept Food Sci & Technol, Davis, CA USA.
C3 United States Department of Agriculture (USDA); University of California
   System; University of California Davis; University of California System;
   University of California Davis; University of California System;
   University of California Davis; University of California System;
   University of California Davis
RP Bennett, BJ (corresponding author), USDA, Obes & Metab Res Unit, Western Human Nutr Res Ctr, 430 W Hlth Sci Dr, Davis, CA 95616 USA.
EM brian.bennett@usda.gov
RI ADAMS, SEAN/N-9262-2018; bennett, brian/ADY-4361-2022
OI Keim, Nancy/0000-0002-6601-7572; Krishnan, Sridevi/0000-0003-2757-6934;
   Newman, John/0000-0001-9632-6571; bennett, brian/0000-0002-0766-3195
FU National Dairy Council; Campbell Soup Co.; USDAARS Projects
   [2032-51530-022-00D, 6026-51000-010-05S]
FX This trial was registered at clinicaltrials.gov as NCT02298725. The
   feeding trial was supported by the National Dairy Council and Campbell
   Soup Co., and USDAARS Projects 2032-51530-022-00D and 6026-51000-01005S.
CR Agriculture USDo, 2015, DIET GUID AM 2015, V8th
   Andraos S, 2021, CURR DEV NUTR, V5, DOI 10.1093/cdn/nzaa179
   Axtell Andrea L, 2010, J Vis Exp, DOI 10.3791/2167
   Bae JH, 2001, ATHEROSCLEROSIS, V155, P517, DOI 10.1016/S0021-9150(00)00601-8
   Bennett BJ, 2013, CELL METAB, V17, P49, DOI 10.1016/j.cmet.2012.12.011
   Bentley-Lewis R, 2007, NAT CLIN PRACT ENDOC, V3, P696, DOI 10.1038/ncpendmet0616
   Brown AA, 2001, AM J CLIN NUTR, V73, P673
   Brown JM, 2015, ANNU REV MED, V66, P343, DOI 10.1146/annurev-med-060513-093205
   Brunt VE, 2020, HYPERTENSION, V76, P101, DOI 10.1161/HYPERTENSIONAHA.120.14759
   Chiesa ST, 2019, CIRCULATION, V140
   Cho CE, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600324
   Chou RH, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-40638-y
   Committee DGA, 2020, SCIENT REP 2020 DIET, P161
   Demarquoy J, 2004, FOOD CHEM, V86, P137, DOI 10.1016/j.foodchem.2003.09.023
   Dong ZX, 2020, BIOSCIENCE REP, V40, DOI 10.1042/BSR20192657
   Fu BC, 2020, AM J CLIN NUTR, V111, P1226, DOI 10.1093/ajcn/nqaa015
   Gerhard GT, 1999, CURR OPIN LIPIDOL, V10, P417, DOI 10.1097/00041433-199910000-00006
   Glick D, 1944, J BIOL CHEM, V156, P643
   Groenewegen KA, 2016, EUR J PREV CARDIOL, V23, P264, DOI 10.1177/2047487314566999
   Gutiérrez E, 2013, EUR HEART J, V34, P3175, DOI 10.1093/eurheartj/eht351
   Haghikia A, 2018, ARTERIOSCL THROM VAS, V38, P2225, DOI 10.1161/ATVBAHA.118.311023
   Hamburg NM, 2008, CIRCULATION, V117, P2467, DOI 10.1161/CIRCULATIONAHA.107.748574
   Hartiala J, 2014, ARTERIOSCL THROM VAS, V34, P1307, DOI 10.1161/ATVBAHA.114.303252
   Heianza Y, 2020, J AM COLL CARDIOL, V75, P763, DOI 10.1016/j.jacc.2019.11.060
   Hill AM, 2015, AM J CLIN NUTR, V102, P757, DOI 10.3945/ajcn.114.104026
   Koay YC, 2020, Cardiovasc Res
   Koay YC, 2021, CARDIOVASC RES, V117, P435, DOI 10.1093/cvr/cvaa094
   Koeth RA, 2013, NAT MED, V19, P576, DOI 10.1038/nm.3145
   Krebs-Smith SM, 2018, J ACAD NUTR DIET, V118, P1591, DOI 10.1016/j.jand.2018.05.021
   Krishnan S, 2020, CURR DEV NUTR, V4, DOI 10.1093/cdn/nzaa022
   Krishnan S, 2018, AM J CLIN NUTR, V108, P266, DOI 10.1093/ajcn/nqy113
   Krüger R, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201700363
   Landfald Bjarne, 2017, Microbial Ecology in Health and Disease, V28, P1327309, DOI 10.1080/16512235.2017.1327309
   Litwin NS, 2019, CURR DEV NUTR, V3, DOI [10.1093/cdn/nzz113, 10.1093/cdn/nzz11]
   Malinowska AM, 2017, INT J FOOD SCI NUTR, V68, P488, DOI 10.1080/09637486.2016.1256379
   McCrea CE, 2012, VASC MED, V17, P29, DOI 10.1177/1358863X11433188
   Metzig AM, 2011, OBESITY, V19, P1279, DOI 10.1038/oby.2010.318
   Meyer KA, 2017, NUTRIENTS, V9, DOI 10.3390/nu9070711
   Meyer KA, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.116.003970
   Meyer KA, 2016, CURR DIABETES REP, V16, DOI 10.1007/s11892-016-0791-x
   Moerland M, 2012, INT J VASC MED, V2012, DOI 10.1155/2012/904141
   Teixeira RDMD, 2007, ARQ BRAS CARDIOL, V89, P237, DOI 10.1590/S0066-782X2007001600005
   Orsama AL, 2014, OBESITY FACTS, V7, P36, DOI 10.1159/000356147
   Papandreou C, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051330
   Promotion OoDPaH, 2010, 2010 DIET GUID, P5
   Randrianarisoa E, 2016, SCI REP-UK, V6, DOI 10.1038/srep26745
   Rochlani Y, 2015, CARDIOVASC DRUG THER, V29, P329, DOI 10.1007/s10557-015-6593-6
   Romano KA, 2015, MBIO, V6, DOI 10.1128/mBio.02481-14
   Seline KG, 2007, FOOD CHEM, V105, P793, DOI 10.1016/j.foodchem.2007.01.058
   Services UDoHaH, 2010, DIET GUID AM, V7th
   Shah B, 2018, J AM HEART ASSOC, V7, DOI [10.1161/JAHA.118.011367, 10.1161/jaha.118.011367]
   Starkey DE, 2008, J AOAC INT, V91, P130
   Subar AF, 2012, J ACAD NUTR DIET, V112, P1134, DOI 10.1016/j.jand.2012.04.016
   Sun XL, 2016, BIOCHEM BIOPH RES CO, V481, P63, DOI 10.1016/j.bbrc.2016.11.017
   Tang WHW, 2015, CIRC RES, V116, P448, DOI 10.1161/CIRCRESAHA.116.305360
   Tang WHW, 2014, J CLIN INVEST, V124, P4204, DOI 10.1172/JCI72331
   Thogersen R, 2020, METABOLITES, V10, DOI 10.3390/metabo10020057
   Villa P, 2005, CRIT CARE, V9, pR139, DOI 10.1186/cc3044
   Vogel RA, 2000, J AM COLL CARDIOL, V36, P1455, DOI 10.1016/S0735-1097(00)00896-2
   Volpe GE, 2014, AIDS RES HUM RETROV, V30, P881, DOI [10.1089/aid.2013.0272, 10.1089/AID.2013.0272]
   Wang ZN, 2019, EUR HEART J, V40, P583, DOI [10.1093/eurheartj/ehy799, 10.109]
   Wang ZN, 2011, NATURE, V472, P57, DOI 10.1038/nature09922
   Wiedeman A, 2015, FASEB J, V29
   Wiedeman AM, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101513
   Zeisel SH, 2003, J NUTR, V133, P1302
   Zhao Yongzhong, 2020, J Lab Precis Med, V5, DOI 10.21037/jlpm.2020.01.01
NR 66
TC 12
Z9 13
U1 0
U2 6
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD JAN
PY 2022
VL 32
IS 1
BP 210
EP 219
DI 10.1016/j.numecd.2021.09.013
EA DEC 2021
PG 10
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA XY4YY
UT WOS:000736981100023
PM 34895998
OA Green Accepted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Eggers, AE
AF Eggers, Arnold E.
TI Extending David Horrobin's membrane phospholipid theory of
   schizophrenia: Overactivity of cytosolic phospholipase A2 in
   the brain is caused by overdrive of coupled serotonergic
   5HT2A/2C receptors in response to stress
SO MEDICAL HYPOTHESES
LA English
DT Article
ID ADIPOSE-TISSUE DEVELOPMENT; INSULIN-RESISTANCE; MIDBRAIN RAPHE; ACID;
   RAT; NEUROGENESIS; 1ST-EPISODE; INVOLVEMENT; METABOLISM; MIGRAINE
AB David Horrobin's membrane phospholipid theory of schizophrenia has held up well over time because his therapeutic prediction that dietary supplementation with eicosapentaenoic acid (EPA) would have a therapeutic effect has been partially verified and undergoes continued testing. In the final version of his theory, he hypothesized that there was hyperactivity of phosphoslipase A(2) (PLA(2)) or a related enzyme but did not explain how the hyperactivity came about. It is known that serotonergic 5HT(2A/2C) receptors are coupled to PLA(2), which hydrolyzes both arachidonic acid (AA) and EPA from diacylglycerides at the sn-2 position. In this paper, Horrobin's theory is combined with a previously published theory of chronic stress in which it was hypothesized that a disinhibited dorsal raphe nucleus, the principal nucleus of the serotonergic system, can organize the neuropathology of diseases such as migraine, hypertension, and the metabolic syndrome. The new or combined theory is that schizophrenia is a disease of chronic stress in which a disinhibited DRN causes widespread serotonergic overdrive in the cerebral cortex. This in turn causes overdrive of cPLA(2) and both central and peripheral depletion of M and EPA. Because EPA is present in smaller amounts, it falls below threshold for maintaining an intracellular balance between AA-derived and EPA-derived second messenger cascades, which leads to abnormal patterns of neuronal firing. There are two causes of neuronal dysfunction: the disinhibited DRN and EPA depletion. Schizophrenia is statistically associated with metabolic syndrome, hypertension, and migraine because they form a cluster of diseases with similar pathophysiology.
   The theory provides an explanation for both the central and peripheral phospholipid abnormalities in schizophrenia. It also explains the role of stress in schizophrenia, elevated serum PLA(2) activity in schizophrenia, the relationship between untreated schizophrenia and metabolic syndrome, and the therapeutic rationale for EPA. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Eggers, Arnold E.] Suny Downstate Med Ctr, Dept Neurol, Brooklyn, NY 11203 USA.
   [Eggers, Arnold E.] Kings Cty Hosp, Brooklyn, NY 11203 USA.
C3 State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University
RP Eggers, AE (corresponding author), Suny Downstate Med Ctr, Dept Neurol, Box 1213, Brooklyn, NY 11203 USA.
EM eggersa@aol.com
CR Ailhaud G, 2006, PROG LIPID RES, V45, P203, DOI 10.1016/j.plipres.2006.01.003
   Balsinde J, 1999, ANNU REV PHARMACOL, V39, P175, DOI 10.1146/annurev.pharmtox.39.1.175
   Cohn TA, 2006, CAN J PSYCHIAT, V51, P382, DOI 10.1177/070674370605100608
   CURRAN DA, 1965, BRAIN, V88, P997, DOI 10.1093/brain/88.5.997
   DANDREA G, 1983, THROMB HAEMOSTASIS, V49, P153
   Eggers AE, 2003, MED HYPOTHESES, V60, P852, DOI 10.1016/S0306-9877(03)00059-8
   Eggers AE, 2007, MED HYPOTHESES, V69, P852, DOI 10.1016/j.mehy.2007.01.074
   Eggers AE, 2006, MED HYPOTHESES, V67, P1065, DOI 10.1016/j.mehy.2006.04.009
   Fukuzako H, 2001, World J Biol Psychiatry, V2, P70
   Goff DC, 2005, SCHIZOPHR RES, V80, P45, DOI 10.1016/j.schres.2005.08.010
   Hannington A, 1981, LANCET, V2, P720
   HORROBIN DF, 1977, LANCET, V1, P936
   Horrobin DF, 1998, SCHIZOPHR RES, V30, P193, DOI 10.1016/S0920-9964(97)00151-5
   Horrobin DF, 2001, MADNESS ADAM EVE, P157
   KOHLER C, 1982, NEUROSCIENCE, V7, P951, DOI 10.1016/0306-4522(82)90054-9
   Malberg JE, 2000, J NEUROSCI, V20, P9104, DOI 10.1523/jneurosci.20-24-09104.2000
   Massiera F, 2003, J LIPID RES, V44, P271, DOI 10.1194/jlr.M200346-JLR200
   Min JH, 1999, BIOCHEMISTRY-US, V38, P12935, DOI 10.1021/bi991149u
   MOORE RY, 1975, J COMP NEUROL, V164, P171, DOI 10.1002/cne.901640203
   NAUTA WJH, 1958, BRAIN, V81, P319, DOI 10.1093/brain/81.3.319
   Ong WY, 2010, CURR MED CHEM, V17, P2746, DOI 10.2174/092986710791859289
   Peet M, 2003, PROSTAG LEUKOTR ESS, V69, P477, DOI 10.1016/j.plefa.2003.08.020
   PETTEGREW JW, 1991, ARCH GEN PSYCHIAT, V48, P563
   Puri BK, 2001, INT J CLIN PRACT, V55, P368
   Rapoport SI, 2001, J MOL NEUROSCI, V16, P243, DOI 10.1385/JMN:16:2-3:243
   Ross BM, 1997, ARCH GEN PSYCHIAT, V54, P487
   Santarelli L, 2003, SCIENCE, V301, P805, DOI 10.1126/science.1083328
   Spelman LM, 2007, DIABETIC MED, V24, P481, DOI 10.1111/j.1464-5491.2007.02092.x
   SUNDLER R, 1994, BIOCHEM J, V301, P455, DOI 10.1042/bj3010455
   THUREN T, 1985, CLIN CHEM, V31, P714
   van Nimwegen LJM, 2008, J CLIN ENDOCR METAB, V93, P572, DOI 10.1210/jc.2007-1167
   Venkatasubramanian G, 2007, AM J PSYCHIAT, V164, P1557, DOI 10.1176/appi.ajp.2007.07020233
   WEILLER C, 1995, NAT MED, V1, P658, DOI 10.1038/nm0795-658
NR 33
TC 8
Z9 9
U1 1
U2 5
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
J9 MED HYPOTHESES
JI Med. Hypotheses
PD DEC
PY 2012
VL 79
IS 6
BP 740
EP 743
DI 10.1016/j.mehy.2012.08.016
PG 4
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 046OE
UT WOS:000311773500009
PM 22986004
DA 2025-06-11
ER

PT J
AU Jakubiak, GK
   Osadnik, K
   Lejawa, M
   Osadnik, T
   Golawski, M
   Lewandowski, P
   Pawlas, N
AF Jakubiak, Grzegorz K.
   Osadnik, Kamila
   Lejawa, Mateusz
   Osadnik, Tadeusz
   Golawski, Marcin
   Lewandowski, Piotr
   Pawlas, Natalia
TI "Obesity and Insulin Resistance" Is the Component of the Metabolic
   Syndrome Most Strongly Associated with Oxidative Stress
SO ANTIOXIDANTS
LA English
DT Article
DE oxidative stress; metabolic syndrome; obesity; insulin resistance;
   diabetes; hypertension; dyslipidemia
ID 3RD NATIONAL-HEALTH; PROVISIONAL REPORT; PREVALENCE; ADOLESCENTS;
   MARKERS; PLASMA; DEFINITION; PHENOTYPE; CHILDREN; DAMAGE
AB Metabolic syndrome (MS) is not a homogeneous entity, but this term refers to the coexistence of factors that increase the risk for the development of type 2 diabetes and cardiovascular disease. There are different versions of the criteria for the diagnosis of MS, which makes the population of patients diagnosed with MS heterogeneous. Research to date shows that MS is associated with oxidative stress (OS), but it is unclear which MS component is most strongly associated with OS. The purpose of the study was to investigate the relationship between the parameters of OS and the presence of individual elements of MS in young adults, as well as to identify the components of MS by means of principal components analysis (PCA) and to investigate how the parameters of OS correlate with the presence of individual components. The study included 724 young adults with or without a family history of coronary heart disease (population of the MAGNETIC study). Blood samples were taken from the participants of the study to determine peripheral blood counts, biochemical parameters, and selected parameters of OS. In addition, blood pressure and anthropometric parameters were measured. In subjects with MS, significantly lower activity of superoxide dismutase (SOD), copper- and zinc-containing SOD (CuZnSOD), and manganese-containing SOD (MnSOD) were found, along with significantly higher total antioxidant capacity (TAC) and significantly lower concentration of thiol groups per gram of protein (PSH). We identified three components of MS by means of PCA: "Obesity and insulin resistance", "Dyslipidemia", and "Blood pressure", and showed the component "Obesity and insulin resistance" to have the strongest relationship with OS. In conclusion, we documented significant differences in some parameters of OS between young adults with and without MS. We showed that "Obesity and insulin resistance" is the most important component of MS in terms of relationship with OS.
C1 [Jakubiak, Grzegorz K.; Osadnik, Kamila; Lejawa, Mateusz; Osadnik, Tadeusz; Pawlas, Natalia] Med Univ Silesia, Fac Med Sci Zabrze, Dept Pharmacol, Jordana 38 St, PL-41808 Zabrze, Poland.
   [Jakubiak, Grzegorz K.] Med Univ Silesia, Fac Med Sci Zabrze, Dept & Clin Internal Med Angiol & Phys Med, Batorego 15 St, PL-41902 Bytom, Poland.
   [Golawski, Marcin; Lewandowski, Piotr] Med Univ Silesia, Fac Med Sci Zabrze, Dept Pharmacol, Student Res Grp, Jordana 38 St, PL-41808 Zabrze, Poland.
C3 Medical University of Silesia; Medical University of Silesia; Medical
   University of Silesia
RP Jakubiak, GK (corresponding author), Med Univ Silesia, Fac Med Sci Zabrze, Dept Pharmacol, Jordana 38 St, PL-41808 Zabrze, Poland.; Jakubiak, GK (corresponding author), Med Univ Silesia, Fac Med Sci Zabrze, Dept & Clin Internal Med Angiol & Phys Med, Batorego 15 St, PL-41902 Bytom, Poland.
EM grzegorz.k.jakubiak@gmail.com; kosadnik@sum.edu.pl;
   mateusz.lejawa@sum.edu.pl; tadeusz.osadnik@sum.edu.pl;
   martin.golawski@gmail.com; lewandop@icloud.com;
   natalia.pawlas@sum.edu.pl
RI Lewandowski, Piotr/GQB-1330-2022; Jakubiak, Grzegorz K./ABC-9750-2021;
   Osadnik, Tadeusz/P-5844-2014; Pawlas, Natalia/H-5796-2013
OI Lewandowski, Piotr/0000-0003-4079-3001; Lejawa,
   Mateusz/0000-0002-1228-7534; Osadnik, Tadeusz/0000-0002-3202-6972;
   Pawlas, Natalia/0000-0002-7551-9371; Golawski,
   Marcin/0000-0001-7891-672X; Osadnik, Kamila/0000-0002-4618-9844;
   Jakubiak, Grzegorz K./0000-0003-0039-8306
FU National Science Centre [UMO-2014/13/B/NZ5/03166]; Medical University of
   Silesia [KNW-1-039/N/8/K]
FX The study was financed by the National Science Centre
   (UMO-2014/13/B/NZ5/03166, OPUS 7) and the Medical University of Silesia
   (Grant No. KNW-1-039/N/8/K).
CR Aguilar MJ, 2013, J CLIN NURS, V22, P2002, DOI 10.1111/jocn.12034
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Anderson RA, 2001, ATHEROSCLEROSIS, V154, P475, DOI 10.1016/S0021-9150(00)00499-8
   Azzazi Y, 2021, PIGM CELL MELANOMA R, V34, P598, DOI 10.1111/pcmr.12941
   Balkau B, 1999, DIABETIC MED, V16, P442
   Cardona F, 2008, EUR J CLIN INVEST, V38, P510, DOI 10.1111/j.1365-2362.2008.01959.x
   Carmona-Maurici J, 2020, EUR J CLIN INVEST, V50, DOI 10.1111/eci.13320
   Chang CH, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-708
   Chen LY, 2012, WORLD J GASTROENTERO, V18, P4215, DOI 10.3748/wjg.v18.i31.4215
   Chen SY, 2014, ENDOCRINE, V46, P496, DOI 10.1007/s12020-013-0079-8
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cook S, 2003, ARCH PEDIAT ADOL MED, V157, P821, DOI 10.1001/archpedi.157.8.821
   Darroudi S, 2019, BIOFACTORS, V45, P35, DOI 10.1002/biof.1459
   de Ferranti SD, 2004, CIRCULATION, V110, P2494, DOI 10.1161/01.CIR.0000145117.40114.C7
   Dentali F, 2009, SEMIN THROMB HEMOST, V35, P451, DOI 10.1055/s-0029-1234140
   Dimitrijevic-Sreckovic V, 2007, CLIN CHEM LAB MED, V45, P1140, DOI 10.1515/CCLM.2007.259
   Dziegielewska-Gesiak S, 2020, EXP BIOL MED, V245, P1260, DOI 10.1177/1535370220929621
   Dziegielewska-Gesiak S, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/987303
   Engin A, 2017, ADV EXP MED BIOL, V960, P1, DOI 10.1007/978-3-319-48382-5_1
   Fagerland MW, 2012, BMC MED RES METHODOL, V12, DOI 10.1186/1471-2288-12-78
   Fazakerley DJ, 2018, J BIOL CHEM, V293, P7315, DOI 10.1074/jbc.RA117.001254
   Fuentes-Venado CE, 2021, METAB SYNDR RELAT D, V19, P513, DOI 10.1089/met.2021.0021
   Fukunaga Megumu, 1993, American Journal of Physiology, V264, pC1619
   Goth Laszlo, 2004, Mol Diagn, V8, P141
   Hailili G, 2021, BRIT J NUTR, V126, P913, DOI 10.1017/S000711452000478X
   Heit C, 2017, FREE RADICAL BIO MED, V103, P48, DOI 10.1016/j.freeradbiomed.2016.12.011
   Henriksen EJ, 2011, FREE RADICAL BIO MED, V51, P993, DOI 10.1016/j.freeradbiomed.2010.12.005
   Hopps E, 2010, NUTR METAB CARDIOVAS, V20, P72, DOI 10.1016/j.numecd.2009.06.002
   Iacobini C, 2019, METABOLISM, V92, P51, DOI 10.1016/j.metabol.2018.11.009
   Jagannathan R, 2019, CURR DIABETES REP, V19, DOI 10.1007/s11892-019-1161-2
   Jakubiak GK, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/9987352
   Janczura M, 2021, DIABET METAB SYND OB, V14, P1783, DOI 10.2147/DMSO.S298596
   Jia XJ, 2019, MEDICINE, V98, DOI [10.1097/MD.0000000000014469, 10.1097/md.0000000000014469]
   Kanikowska D, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10071018
   Kim CH, 2002, METABOLISM, V51, P838, DOI 10.1053/meta.2002.33348
   Korkmaz GG, 2013, METABOLISM, V62, P828, DOI 10.1016/j.metabol.2013.01.002
   Koter M, 2004, INT J BIOCHEM CELL B, V36, P205, DOI 10.1016/S1357-2725(03)00195-X
   Kubong Landry Nguepnkep, 2020, Adv Hematol, V2020, P9864371, DOI 10.1155/2020/9864371
   Lewandowski L, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21145069
   Li TX, 2021, ENVIRON RES, V200, DOI 10.1016/j.envres.2021.111354
   Loos RJF, 2003, J CLIN ENDOCR METAB, V88, P5935, DOI 10.1210/jc.2003-030553
   Luc K, 2019, J PHYSIOL PHARMACOL, V70, P809, DOI 10.26402/jpp.2019.6.01
   Ma ML, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-01303-w
   Maciejczyk M, 2020, J CLIN MED, V9, DOI 10.3390/jcm9030837
   Matsuda M, 2013, OBES RES CLIN PRACT, V7, pE330, DOI 10.1016/j.orcp.2013.05.004
   Metere A, 2020, BIOMEDICINES, V8, DOI 10.3390/biomedicines8060168
   Le MT, 2018, ENDOCRINOL METAB, V33, P447, DOI 10.3803/EnM.2018.33.4.447
   Mohseni R, 2018, J PEDIATR ENDOCR MET, V31, P727, DOI 10.1515/jpem-2017-0322
   Morrison CD, 2015, BEST PRACT RES CL OB, V29, P507, DOI 10.1016/j.bpobgyn.2014.10.006
   Mustapic S, 2018, CAN J GASTROENTEROL, V2018, DOI 10.1155/2018/8490242
   Odegaard AO, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-016-0369-6
   Osadnik T, 2019, ARCH MED SCI, V15, P590, DOI 10.5114/aoms.2018.75895
   Poznyak AV, 2021, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.613780
   Prado AF, 2021, BIOMOLECULES, V11, DOI 10.3390/biom11040585
   Reinehr T, 2007, ARCH DIS CHILD, V92, P1067, DOI 10.1136/adc.2006.104588
   Safavi SM, 2012, J OBES, V2012, DOI 10.1155/2012/951093
   Shahinfar H, 2020, J DIABETES METAB DIS, V19, P1071, DOI 10.1007/s40200-020-00607-z
   Shin SK, 2020, REDOX BIOL, V37, DOI 10.1016/j.redox.2020.101749
   Shin SK, 2019, PFLUG ARCH EUR J PHY, V471, P829, DOI 10.1007/s00424-018-02250-3
   Simic DV, 2006, J HUM HYPERTENS, V20, P149, DOI 10.1038/sj.jhh.1001945
   Skalnaya MG, 2017, J TRACE ELEM MED BIO, V43, P46, DOI 10.1016/j.jtemb.2016.11.005
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   TAKAHASHI K, 1992, J CLIN INVEST, V90, P136, DOI 10.1172/JCI115826
   Vávrová L, 2013, OBESITY FACTS, V6, P39, DOI 10.1159/000348569
   Vichaibun V, 2019, DIABETES METAB SYND, V13, P90, DOI 10.1016/j.dsx.2018.08.029
   Viner RM, 2005, ARCH DIS CHILD, V90, P10, DOI 10.1136/adc.2003.036467
   Wang HH, 2020, PEDIATR GASTROENTERO, V23, P189
   Wang MX, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.649785
   Wang Z, 2021, J CLIN MED, V10, DOI 10.3390/jcm10184243
   Weiss R, 2004, NEW ENGL J MED, V350, P2362, DOI 10.1056/NEJMoa031049
   Wen J, 2020, J CLIN LAB ANAL, V34, DOI 10.1002/jcla.23161
   Wiley JF, 2016, PREV MED, V88, P189, DOI 10.1016/j.ypmed.2016.04.006
   Yaribeygi H, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/8609213
   Ziobro A, 2013, MOL CELL BIOCHEM, V378, P267, DOI 10.1007/s11010-013-1617-7
NR 75
TC 70
Z9 73
U1 1
U2 46
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JAN
PY 2022
VL 11
IS 1
AR 79
DI 10.3390/antiox11010079
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA ZE0QM
UT WOS:000758596800001
PM 35052583
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rani, M
   Aggarwal, R
   Vohra, K
AF Rani, Monika
   Aggarwal, Rohit
   Vohra, Kanchan
TI Effect of N-Acetylcysteine on Metabolic Profile in Metabolic Syndrome
   Patients
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE oxidative stress; low-grade systemic inflammation; multiple
   pharmacological properties; insulin resistance; endothelial dysfunction;
   metabolic syndrome
ID VITAMIN-D SUPPLEMENTATION; OXIDATIVE STRESS; BLOOD-PRESSURE; INSULIN
   SENSITIVITY; ACETYL-CYSTEINE; RISK-FACTORS; WOMEN; ACTIVATION; METFORMIN
AB Background:N-acetylcysteine (NAC), the acetylated variant of amino acidl-cysteine, acts as a free radical scavenger and plays multifunctional roles by suppressing endogenous level of oxidative stress and inflammation and by enhancing nitric oxide bioavailability. Thus, present study aimed to evaluate the efficacy of NAC on various inherent components of metabolic syndrome (MetS). Methods:An open-label pilot study was conducted at diabetes outpatient clinic. Thirty-five patients (aged >= 18 years) fulfilling the NCEP-ATP III diagnostic criteria for MetS were recruited and allocated to NAC tablets as 600 mg (twice a day) along with their ongoing therapeutic regimen. Blood pressure (BP), body mass index, lipid profile, fasting plasma glucose and insulin, insulin resistance estimated by homeostatic model assessment (HOMA-IR), high-sensitivity C-reactive proteins (hsCRP), nitrite, and thiobarbituric acid reactive substances (TBARS) were measured after 6 weeks treatment. Results:HOMA-IR, hsCRP and systolic BP were decreased significantly from 4.74 +/- 0.30% to 3.86 +/- 0.21%; 5.66 +/- 0.27 to 4.92 +/- 0.18 mg/L; and 133.2 +/- 1.84 to 128.3 +/- 1.52 mmHg, respectively. Among dyslipidemic variables, there was decrease in triglycerides from 194.20 +/- 5.03 to 188.04 +/- 4.93 mg/dL, but increase in HDL from 33.32 +/- 0.19 to 36.29 +/- 1.16 mg/dL. Nitrite levels were significantly increased from 6.25 +/- 0.20 to 7.92 +/- 0.18 mu mol/L (P = 0.04), while TBARS levels were decreased from 14.65 +/- 0.32 to 13.68 +/- 0.33 nmol/L (P = 0.05). It was found from correlation analysis that hsCRP was the main culprit, that is, inflammation was perpetuator of endothelial dysfunction, IR, oxidative stress, hypertension, andvice-versa. Conclusion:This study has provided a new approach of management of MetS with NAC beyond controlling the disease with various drug therapies. NAC may reduce the risk burden via multiple antioxidant, anti-inflammatory, and vasodilatory effect.
C1 [Rani, Monika; Vohra, Kanchan] Punjabi Univ, Dept Pharmaceut Sci & Drug Res, Pharm Practice, Patiala, Punjab, India.
   [Aggarwal, Rohit] Aggarwal Hlth Care, Endocrinol, Patiala, Punjab, India.
C3 Punjabi University
RP Vohra, K (corresponding author), Punjabi Univ, Dept Pharmaceut Sci & Drug Res, Patiala 147002, Punjab, India.
EM kanchan_vohra23@yahoo.com
FU NIL (the academic institute Punjabi University, Patiala, Punjab)
FX NIL (the academic institute Punjabi University, Patiala, Punjab provided
   the candidate all the financial support for carrying the research work).
CR Abd El-Aal A, 2018, DIABETES METAB SYND, V12, P483, DOI 10.1016/j.dsx.2018.03.013
   BORGSTROM L, 1990, BIOPHARM DRUG DISPOS, V11, P131, DOI 10.1002/bdd.2510110205
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Csontos C, 2012, BURNS, V38, P428, DOI 10.1016/j.burns.2011.09.011
   Fulghesu AM, 2002, FERTIL STERIL, V77, P1128, DOI 10.1016/S0015-0282(02)03133-3
   Gama CS, 2008, NEUROSCI LETT, V433, P270, DOI 10.1016/j.neulet.2008.01.018
   Godala MM, 2016, ADV CLIN EXP MED, V25, P689, DOI 10.17219/acem/41049
   Hendarto A, 2019, ACTA MED INDONES, V51, P110
   Hodgson JM, 2014, BRIT J NUTR, V112, P1551, DOI 10.1017/S0007114514002542
   Kanchan V, 2016, DIABETES METAB, V42, P65, DOI 10.1016/j.diabet.2015.10.005
   Kim S, 2017, NUTRIENTS, V9, DOI 10.3390/nu9101055
   Kuleci S, 2008, ADV THER, V25, P710, DOI 10.1007/s12325-008-0064-4
   Leelarungrayub D, 2011, OXID MED CELL LONGEV, V2011, DOI 10.1155/2011/329643
   Mangge H, 2015, CURR PHARM DESIGN, V21, P2243, DOI 10.2174/1381612821666150105160931
   Martina V, 2008, DIABETES CARE, V31, P940, DOI 10.2337/dc07-2251
   Mason SA, 2019, DIABETES OBES METAB, V21, P674, DOI 10.1111/dom.13571
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McMullan CJ, 2017, J HYPERTENS, V35, P822, DOI 10.1097/HJH.0000000000001220
   Nascimento MM, 2010, PERITON DIALYSIS INT, V30, P336, DOI 10.3747/pdi.2009.00073
   Nur E, 2012, ANN HEMATOL, V91, P1097, DOI 10.1007/s00277-011-1404-z
   Oner G, 2011, EUR J OBSTET GYN R B, V159, P127, DOI 10.1016/j.ejogrb.2011.07.005
   Oosterwerff MM, 2014, AM J CLIN NUTR, V100, P152, DOI 10.3945/ajcn.113.069260
   PENDYALA L, 1995, CANCER EPIDEM BIOMAR, V4, P245
   Pilz S, 2015, HYPERTENSION, V65, P1195, DOI 10.1161/HYPERTENSIONAHA.115.05319
   Rafraf M, 2016, J AM COLL NUTR, V35, P521, DOI 10.1080/07315724.2015.1116896
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Salekzamani S, 2016, J ENDOCRINOL INVEST, V39, P1303, DOI 10.1007/s40618-016-0507-8
   Sastry KVH, 2002, ANAL BIOCHEM, V306, P79, DOI 10.1006/abio.2002.5676
   Tomson J, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.117.005707
   Trummer C, 2019, EUR J NUTR, V58, P2019, DOI 10.1007/s00394-018-1760-8
   Vitale C, 2005, J INTERN MED, V258, P250, DOI 10.1111/j.1365-2796.2005.01531.x
   Wang QZ, 2010, INT J VITAM NUTR RES, V80, P178, DOI 10.1024/0300-9831/a000015
   Wu L, 2017, J HUM HYPERTENS, V31, P547, DOI 10.1038/jhh.2017.12
   Zafarullah M, 2003, CELL MOL LIFE SCI, V60, P6, DOI 10.1007/s000180300001
NR 35
TC 12
Z9 12
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD SEP 1
PY 2020
VL 18
IS 7
BP 341
EP 346
DI 10.1089/met.2020.0017
EA JUN 2020
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA NO2MD
UT WOS:000541948800001
PM 32552298
DA 2025-06-11
ER

PT J
AU Mutruc, V
   Bologa, C
   Sorodoc, V
   Ceasovschih, A
   Morarasu, BC
   Sorodoc, L
   Catar, OE
   Lionte, C
AF Mutruc, Victoria
   Bologa, Cristina
   Sorodoc, Victorita
   Ceasovschih, Alexandr
   Morarasu, Bianca Codrina
   Sorodoc, Laurentiu
   Catar, Oana Elena
   Lionte, Catalina
TI Cardiovascular-Kidney-Metabolic Syndrome: A New Paradigm in Clinical
   Medicine or Going Back to Basics?
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE hypertension; chronic kidney disease; diabetes; metabolic syndrome;
   obesity; heart failure; cardiovascular-kidney-metabolic syndrome
ID HEART-FAILURE; AMERICAN-COLLEGE; SCIENTIFIC STATEMENT; PRACTICE
   GUIDELINES; RISK PREDICTION; OBESITY; DISEASE; MANAGEMENT; ASSOCIATION;
   ADULTS
AB Cardiovascular, renal, and metabolic diseases are pathophysiologically interdependent, posing a significant global health challenge and being associated with a substantial increase in morbidity and mortality. In 2023, the American Heart Association (AHA) defined this complex network of interconnected health conditions as the cardiovascular-kidney-metabolic (CKM) syndrome. This syndrome is based on common pathophysiological mechanisms, including chronic inflammation, oxidative stress, hyperglycemia and insulin resistance, activation of the renin-angiotensin-aldosterone system (RAAS), and neurohormonal dysfunction, which trigger a vicious cycle where the impairment of one organ contributes to the progressive deterioration of the others. An integrated approach to these conditions, rather than treating them as separate entities, supports a holistic management strategy that helps to reduce the burden on public health and improve patients' quality of life. Existing management focuses on lifestyle modification, glycemic and lipid control, and the use of nephroprotective and cardioprotective therapies. This narrative review aims to synthesize and contextualize existing information on the complex interactions between these systems and on diagnostic approaches, as well as to provide an overview of the available therapeutic options.
C1 [Mutruc, Victoria; Bologa, Cristina; Sorodoc, Victorita; Ceasovschih, Alexandr; Morarasu, Bianca Codrina; Sorodoc, Laurentiu; Lionte, Catalina] Grigore T Popa Univ Med & Pharm, Fac Med, Iasi 700115, Romania.
   [Mutruc, Victoria; Bologa, Cristina; Sorodoc, Victorita; Ceasovschih, Alexandr; Morarasu, Bianca Codrina; Sorodoc, Laurentiu; Lionte, Catalina] Sf Spiridon Clin Emergency Hosp, Internal Med Dept 2, Iasi 700111, Romania.
   [Catar, Oana Elena] Ctr Hosp Univ Angers, Dept Neurol, F-49933 Angers 9, France.
C3 Grigore T Popa University of Medicine & Pharmacy; Universite d'Angers;
   Centre Hospitalier Universitaire d'Angers
RP Mutruc, V; Lionte, C (corresponding author), Grigore T Popa Univ Med & Pharm, Fac Med, Iasi 700115, Romania.; Mutruc, V; Lionte, C (corresponding author), Sf Spiridon Clin Emergency Hosp, Internal Med Dept 2, Iasi 700111, Romania.
EM victoria.mutruc@yahoo.com; cristina.bologa@umfiasi.ro;
   victorita.sorodoc@umfiasi.ro; alexandr.ceasovschih@umfiasi.ro;
   morarasu.bianca.codrina@gmail.com; laurentiu.sorodoc@umfiasi.ro;
   oanaelena.catar@chu-angers.fr; catalina.lionte@umfiasi.ro
RI Morarasu, Bianca-Codrina/GXN-0229-2022; Ceasovschih,
   Alexandr/AAF-2773-2021; Șorodoc, Laurențiu/GZM-0059-2022; VICTORITA,
   SORODOC/AGH-5818-2022; Cristina, Bologa/KWU-8665-2024; LIONTE,
   CATALINA/A-5283-2013
OI LIONTE, CATALINA/0000-0002-0525-0645; Ceasovschih,
   Alexandr/0000-0002-0043-9051
CR Afshin A, 2017, NEW ENGL J MED, V377, P13, DOI 10.1056/NEJMoa1614362
   Agarwal R, 2022, EUR HEART J, V43, P474, DOI 10.1093/eurheartj/ehab777
   Ahwin P, 2024, HYPERTENS RES, V47, P2094, DOI 10.1038/s41440-024-01723-6
   Alemany M, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25042251
   AmerDiabetAssocProfessionalPractice, 2025, DIABETES CARE, V48, pS128, DOI 10.2337/dc25-S006
   Anker SD, 2021, NEW ENGL J MED, V385, P1451, DOI 10.1056/NEJMoa2107038
   [Anonymous], 2024, Kidney Int, V3, pS117
   Arneth B., 2024, ENDOCRINES, V5, P153, DOI [10.3390/endocrines5020011, DOI 10.3390/ENDOCRINES5020011]
   Barrera-Chimal J, 2019, KIDNEY INT, V96, P302, DOI 10.1016/j.kint.2019.02.030
   Bauersachs J, 2015, HYPERTENSION, V65, P257, DOI 10.1161/HYPERTENSIONAHA.114.04488
   Bhatt DL, 2021, NEW ENGL J MED, V384, P117, DOI 10.1056/NEJMoa2030183
   Bhatt DL, 2021, NEW ENGL J MED, V384, P129, DOI 10.1056/NEJMoa2030186
   Biwer LA, 2019, AM J HYPERTENS, V32, P123, DOI 10.1093/ajh/hpy158
   Bonaca MP, 2025, LANCET, V405, P1580, DOI 10.1016/S0140-6736(25)00509-4
   Borlaug BA, 2023, J AM COLL CARDIOL, V81, P1810, DOI 10.1016/j.jacc.2023.01.049
   Braam B, 2014, NAT REV NEPHROL, V10, P48, DOI 10.1038/nrneph.2013.250
   Braunwald E, 2024, EUR HEART J, V46, P682, DOI 10.1093/eurheartj/ehae775
   Buonafine M, 2018, AM J HYPERTENS, V31, P1165, DOI 10.1093/ajh/hpy120
   Cao YF, 2025, BMC PUBLIC HEALTH, V25, DOI 10.1186/s12889-024-21131-2
   Carpenter CL, 2013, J OBES, V2013, DOI 10.1155/2013/790654
   Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI 10.1002/hep.29367
   Chertow G.M., 2023, AM SOC NEPHR ASN KID
   Claudel SE, 2025, CIRCULATION, V151, P716, DOI 10.1161/CIRCULATIONAHA.124.071079
   Claudel SE, 2024, EUR J INTERN MED, V121, P152, DOI 10.1016/j.ejim.2023.12.006
   Claudel SE, 2023, CELL METAB, V35, P2104, DOI 10.1016/j.cmet.2023.10.015
   Costantino VV, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10113146
   Davies M, 2021, LANCET, V397, P971, DOI 10.1016/S0140-6736(21)00213-0
   Davies MJ, 2015, JAMA-J AM MED ASSOC, V314, P687, DOI 10.1001/jama.2015.9676
   de Vries TI, 2021, EUR HEART J, V42, P2455, DOI 10.1093/eurheartj/ehab312
   Després JP, 2021, J AM COLL CARDIOL, V78, P513, DOI 10.1016/j.jacc.2021.05.035
   El Chamieh C, 2022, TOXINS, V14, DOI 10.3390/toxins14040280
   El Meouchy P, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms232012305
   Elsayed NA, 2025, DIABETES CARE, V48, pS27, DOI 10.2337/dc25-S002
   Elsayed NA, 2024, DIABETES CARE, V47, pS219, DOI 10.2337/dc24-S011
   Emberson MA, 2021, BIOMED RES INT, V2021, DOI 10.1155/2021/6296896
   Emerging Risk Factors Collaboration, 2010, Lancet, V375, P2215, DOI 10.1016/S0140-6736(10)60484-9
   Eslam M, 2020, J HEPATOL, V73, P202, DOI 10.1016/j.jhep.2020.03.039
   Filippatos G, 2022, CIRCULATION, V145, P437, DOI 10.1161/CIRCULATIONAHA.121.057983
   Gaggin H.K., 2023, Expert analysis
   Gao CX, 2024, SCI REP-UK, V14, DOI 10.1038/s41598-024-69819-0
   Garvey WT, 2016, ENDOCR PRACT, V22, P1, DOI 10.4158/EP161365.GL
   GBD 2021 Diabetes Collaborators, 2023, LANCET, V402, P203, DOI DOI 10.1016/S0140-6736(23)01301-6
   Gepner AD, 2015, CIRC-CARDIOVASC IMAG, V8, DOI 10.1161/CIRCIMAGING.114.002262
   Golub IS, 2023, JACC-CARDIOVASC IMAG, V16, P98, DOI 10.1016/j.jcmg.2022.06.018
   Guldan M, 2024, J CLIN MED, V13, DOI 10.3390/jcm13154354
   Hageman SHJ, 2024, EUR HEART J, V46, P702, DOI 10.1093/eurheartj/ehae609
   Hageman SHJ, 2024, EUR J PREV CARDIOL, V31, P1690, DOI 10.1093/eurjpc/zwae174
   Handelsman Y, 2024, METABOLISM, V159, DOI 10.1016/j.metabol.2024.155931
   Heerspink HJL, 2020, NEW ENGL J MED, V383, P1436, DOI 10.1056/NEJMoa2024816
   [Anonymous], 2022, Circulation, V145, pe1033, DOI [10.1161/CIR.0000000000001063, 10.1161/CIR.0000000000001073]
   Herrington WG, 2023, NEW ENGL J MED, V388, P117, DOI 10.1056/NEJMoa2204233
   Hill-Briggs F, 2021, DIABETES CARE, V44, P258, DOI 10.2337/dci20-0053
   Hong JN, 2025, CARDIOVASC DIABETOL, V24, DOI 10.1186/s12933-025-02662-3
   Jastreboff Ania M, 2025, N Engl J Med, V392, P958, DOI 10.1056/NEJMoa2410819
   Jastreboff AM, 2022, NEW ENGL J MED, V387, P205, DOI 10.1056/NEJMoa2206038
   Jastreboff AM, 2023, NEW ENGL J MED, V389, P514, DOI 10.1056/NEJMoa2301972
   Jensen MD, 2014, J AM COLL CARDIOL, V63, P2985, DOI 10.1016/j.jacc.2013.11.004
   Jha R, 2024, BIOMEDICINES, V12, DOI 10.3390/biomedicines12051098
   Ji HW, 2025, ARTERIOSCL THROM VAS, V45, P157, DOI 10.1161/ATVBAHA.124.321629
   Jia XM, 2023, JACC-HEART FAIL, V11, P440, DOI 10.1016/j.jchf.2022.12.005
   Kanbay M, 2024, EUR J INTERN MED, V127, P1, DOI 10.1016/j.ejim.2024.07.014
   Katsiki N, 2021, EXPERT REV CARDIOVAS, V19, P1127, DOI 10.1080/14779072.2021.2021071
   Kayani M, 2024, CUREUS J MED SCIENCE, V16, DOI 10.7759/cureus.53445
   Khan SS, 2023, CIRCULATION, V148, P1982, DOI 10.1161/CIR.0000000000001191
   Kittelson KS, 2024, PROG CARDIOVASC DIS, V87, P26, DOI 10.1016/j.pcad.2024.10.012
   Klop B, 2013, NUTRIENTS, V5, P1218, DOI 10.3390/nu5041218
   Koenen M, 2021, CIRC RES, V128, P951, DOI 10.1161/CIRCRESAHA.121.318093
   Kolkhof P, 2017, HANDB EXP PHARMACOL, V243, P271, DOI 10.1007/164_2016_76
   Kosiborod MN, 2024, NEW ENGL J MED, V390, P1394, DOI 10.1056/NEJMoa2313917
   Kosiborod MN, 2023, NEW ENGL J MED, V389, P1069, DOI 10.1056/NEJMoa2306963
   Koskinas KC, 2024, EUR HEART J, V45, P4063, DOI 10.1093/eurheartj/ehae508
   Kreiner FF, 2023, BIOMEDICINES, V11, DOI 10.3390/biomedicines11092498
   Kronenberg F, 2022, EUR HEART J, V43, P3925, DOI 10.1093/eurheartj/ehac361
   Krumholz HM, 2024, HEART, V110, P1165, DOI 10.1136/heartjnl-2024-324170
   Lanlan W., 2024, Sci. Rep, V14
   Larqué E, 2019, NAT REV ENDOCRINOL, V15, P456, DOI 10.1038/s41574-019-0219-1
   Li YW, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-89307-z
   Lincoff AM, 2023, NEW ENGL J MED, V389, P2221, DOI 10.1056/NEJMoa2307563
   Lloyd-Jones DM, 2022, CIRCULATION, V146, pE18, DOI 10.1161/CIR.0000000000001078
   Longo M, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20092358
   Maddox TM, 2024, J AM COLL CARDIOL, V83, P1444, DOI 10.1016/j.jacc.2023.12.024
   Maloberti A, 2023, HIGH BLOOD PRESS CAR, V30, P411, DOI 10.1007/s40292-023-00602-4
   Marc-Andre C., 2022, Am. J. Manag. Care, V28, P15
   Marx N, 2023, EUR HEART J, V44, P4043, DOI 10.1093/eurheartj/ehad192
   Massy ZA, 2024, KIDNEY INT REP, V9, P2608, DOI 10.1016/j.ekir.2024.05.033
   Matsushita K, 2023, EUR J PREV CARDIOL, V30, P8, DOI 10.1093/eurjpc/zwac176
   McDonagh TA, 2021, EUR HEART J, V42, P3599, DOI 10.1093/eurheartj/ehab368
   McEvoy JW, 2024, EUR HEART J, V45, P3912, DOI 10.1093/eurheartj/ehae178
   McGuire DK, 2025, NEW ENGL J MED, DOI 10.1056/NEJMoa2501006
   McGuire DK, 2021, JAMA CARDIOL, V6, P148, DOI 10.1001/jamacardio.2020.4511
   McMurray JJV, 2019, NEW ENGL J MED, V381, P1995, DOI 10.1056/NEJMoa1911303
   Mosenzon O, 2021, CARDIOVASC DIABETOL, V20, DOI 10.1186/s12933-021-01344-0
   Ndumele CE, 2023, CIRCULATION, V148, P1636, DOI 10.1161/CIR.0000000000001186
   Ndumele CE, 2023, CIRCULATION, V148, P1606, DOI 10.1161/CIR.0000000000001184
   Nikolaou Maria, 2024, Hellenic J Cardiol, DOI 10.1016/j.hjc.2024.08.009
   Ostrominski JW, 2023, JAMA CARDIOL, V8, P1050, DOI 10.1001/jamacardio.2023.3241
   Packer M, 2025, J AM COLL CARDIOL, V85, P1721, DOI 10.1016/j.jacc.2025.03.009
   Packer M, 2025, NEW ENGL J MED, V392, P427, DOI 10.1056/NEJMoa2410027
   Packer M, 2020, NEW ENGL J MED, V383, P1413, DOI 10.1056/NEJMoa2022190
   Palaniappan LP, 2011, INT J OBESITY, V35, P393, DOI 10.1038/ijo.2010.152
   Panattoni G, 2025, EUR HEART J SUPPL, V27, pi16, DOI 10.1093/eurheartjsupp/suae100
   Pennells L, 2023, EUR HEART J, V44, P2544, DOI 10.1093/eurheartj/ehad260
   Perkovic V, 2024, NEW ENGL J MED, V391, P109, DOI 10.1056/NEJMoa2403347
   Pi-Sunyer X, 2015, NEW ENGL J MED, V373, P11, DOI 10.1056/NEJMoa1411892
   Polonsky TS, 2010, JAMA-J AM MED ASSOC, V303, P1610, DOI 10.1001/jama.2010.461
   Powell-Wiley TM, 2022, CIRC RES, V130, P782, DOI 10.1161/CIRCRESAHA.121.319811
   Powell-Wiley TM, 2021, CIRCULATION, V143, pE984, DOI 10.1161/CIR.0000000000000973
   Rando MM, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.1011665
   Rangaswami J, 2019, CIRCULATION, V139, pE840, DOI 10.1161/CIR.0000000000000664
   Roth GA, 2020, J AM COLL CARDIOL, V76, P2982, DOI 10.1016/j.jacc.2020.11.010
   Rubino F, 2025, LANCET DIABETES ENDO, V13, P221, DOI 10.1016/S2213-8587(24)00316-4
   Ruiz-García A, 2023, J CLIN MED, V12, DOI 10.3390/jcm12154924
   Sanyal AJ, 2024, NAT MED, V30, P2037, DOI 10.1038/s41591-024-03018-2
   Sattar N, 2021, LANCET DIABETES ENDO, V9, P653, DOI 10.1016/S2213-8587(21)00203-5
   Sharaiha RZ, 2023, J CLIN GASTROENTEROL, V57, P967, DOI 10.1097/MCG.0000000000001916
   Shi YM, 2023, CARDIOVASC DIABETOL, V22, DOI 10.1186/s12933-023-01740-8
   Sindhu D, 2023, MEDICINE, V102, DOI 10.1097/MD.0000000000033366
   Solomon SD, 2024, NEW ENGL J MED, V391, P1475, DOI 10.1056/NEJMoa2407107
   Solomon SD, 2021, EUR J HEART FAIL, V23, P1217, DOI 10.1002/ejhf.2249
   Staplin N, 2022, LANCET, V400, P1788, DOI 10.1016/S0140-6736(22)02074-8
   Stefanska K, 2025, CARDIOVASC RES, V121, P1, DOI 10.1093/cvr/cvaf001
   Sun H, 2023, DIABETES RES CLIN PR, V204, DOI 10.1016/j.diabres.2023.110945
   Szlagor M, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24032988
   Thomas G, 2011, CLIN J AM SOC NEPHRO, V6, P2364, DOI 10.2215/CJN.02180311
   Thomas MC, 2015, NAT REV DIS PRIMERS, V1, DOI 10.1038/nrdp.2015.18
   Trimarco V, 2024, DIABETES RES CLIN PR, V218, DOI 10.1016/j.diabres.2024.111926
   Vaduganathan M, 2022, LANCET, V400, P757, DOI 10.1016/S0140-6736(22)01429-5
   Visseren FLJ, 2022, EUR J PREV CARDIOL, V29, P5, DOI [10.1093/eurjpc/zwab154, 10.1093/eurheartj/ehac458, 10.1093/eurheartj/ehab484]
   Wang Q, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0932-0
   Wharton S, 2020, CAN MED ASSOC J, V192, pE875, DOI 10.1503/cmaj.191707
   WHO, 2019, Classification of diabetes mellitus
   Wilding JPH, 2021, NEW ENGL J MED, V384, P989, DOI 10.1056/NEJMoa2032183
   World Obesity Federation, 2025, World Obesity Atlas
   Wu XY, 2025, FRONT MED-LAUSANNE, V11, DOI 10.3389/fmed.2024.1477343
   Xanthopoulos A, 2023, J CLIN MED, V12, DOI 10.3390/jcm12186105
   Zhang Y, 2025, FRONT ENDOCRINOL, V16, DOI 10.3389/fendo.2025.1517658
   Zhu YY, 2019, DIABETES CARE, V42, P2211, DOI 10.2337/dc19-0532
NR 137
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD APR 19
PY 2025
VL 14
IS 8
AR 2833
DI 10.3390/jcm14082833
PG 28
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 1WV1W
UT WOS:001475534200001
PM 40283662
DA 2025-06-11
ER

PT J
AU Marjani, A
   Sajedi, A
AF Marjani, Abdoljalal
   Sajedi, Atefe
TI Age and gender related paraoxonase I gene polymorphisms rs662 and
   rs854560 and serum activity in subjects with metabolic syndrome in Fars
   ethnic group
SO JOURNAL OF KRISHNA INSTITUTE OF MEDICAL SCIENCES UNIVERSITY
LA English
DT Article
DE Gender; Paraoxonase I; Metabolic Syndrome; Fars; Age
ID OXIDATIVE STRESS; PON1; DISEASE; RISK; PREVALENCE; PHENOTYPES; ADULTS
AB Background: The prevalence of Metabolic Syndrome (MetS) is different among different populations. The human Paraoxonase (PON) genes have been less reported in the literature. So it is a need of hour to study PON. Aim and Objectives: To determine the Paraoxonase I (PON1) gene polymorphisms and its paraoxonase activity in subjects with were done using Polymerase Chain Reaction (PCR) and Restriction Fragment Length Polymorphism (RFLP) analysis. Results: The MM, LM, and LL genotype frequencies of the PON1- L55M polymorphism were 2.5, 37.5 and 60%; and 27.6, 34.5 and 37.9% and; 19.4, 50 and 30.6% and 17.2, 58.6 and 34.2% in females and males with and without MetS, respectively. Females with L allele of L55M polymorphism had a nearly 14.86 -fold risk of developing MetS. Conclusion: Our study suggested that the decrease of PON1 enzymatic activity in both genders is an important finding, but the L55M genotype and L allele in females with MetS are more important risk factors of MetS than PON1 Q192R polymorphism. This difference in L55M among females may make them more vulnerable than males to MetS.
C1 [Marjani, Abdoljalal; Sajedi, Atefe] Golestan Univ Med Sci, Gorgan Fac Med, Metab Disorders Res Ctr, Dept Biochem & Biophys, Gorgan, Golestan Provin, Iran.
   [Marjani, Abdoljalal] Golestan Univ Med Sci, Fac Med, Metab Disorders Res Ctr, Dept Biochem & Biophys, Gorgan, Golestan Provin, Iran.
C3 Golestan University of Medical Sciences; Golestan University of Medical
   Sciences
RP Marjani, A (corresponding author), Golestan Univ Med Sci, Fac Med, Metab Disorders Res Ctr, Dept Biochem & Biophys, Gorgan, Golestan Provin, Iran.
EM drmarjani@goums.ac.ir
RI Marjani, Abdol/P-8976-2017
FU Research Deputy of Golestan University of Medical Science
FX This work has been supported by Research Deputy of Golestan University
   of Medical Science.
CR Acuña M, 2004, HUM BIOL, V76, P299, DOI 10.1353/hub.2004.0027
   Altuner D, 2011, TOXICOL IND HEALTH, V27, P873, DOI 10.1177/0748233711399317
   Bayrak A, 2012, J ATHEROSCLER THROMB, V19, P376, DOI 10.5551/jat.11320
   Bounafaa A, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0133719
   Brophy VH, 2001, AM J HUM GENET, V68, P1428, DOI 10.1086/320600
   Campo S, 2004, EXP GERONTOL, V39, P1089, DOI 10.1016/j.exger.2004.03.017
   Chang M, 1995, PHARMACOGENETICS, V5, P358, DOI 10.1097/00008571-199512000-00004
   Clarke L, 2017, NUCLEIC ACIDS RES, V45, pD854, DOI 10.1093/nar/gkw829
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Costa LG, 2005, BIOCHEM PHARMACOL, V69, P541, DOI 10.1016/j.bcp.2004.08.027
   Davis KA, 2009, ENVIRON HEALTH PERSP, V117, P1226, DOI 10.1289/ehp.0900569
   Deakin S, 2002, J CLIN ENDOCR METAB, V87, P1268, DOI 10.1210/jc.87.3.1268
   Demirdogen BC, 2009, CELL BIOCHEM FUNCT, V27, P558, DOI 10.1002/cbf.1607
   ECKERSON HW, 1983, AM J HUM GENET, V35, P214
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Gamboa R, 2006, EXP MOL PATHOL, V80, P85, DOI 10.1016/j.yexmp.2005.05.006
   Garin MCB, 1997, J CLIN INVEST, V99, P62, DOI 10.1172/JCI119134
   Hernández-Díaz Y, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000005298
   Huen K, 2009, ENVIRON HEALTH PERSP, V117, P1632, DOI 10.1289/ehp.0900870
   Mackness M, 2015, GENE, V567, P12, DOI 10.1016/j.gene.2015.04.088
   Marjani A, 2012, ADV STUD BIOL, V4, P363
   Mohammed CJ, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11030590
   Paragh G, 2009, NEPHRON CLIN PRACT, V113, pC46, DOI 10.1159/000228075
   Rios DLS, 2007, CLIN CHEM LAB MED, V45, P874, DOI 10.1515/CCLM.2007.136
   Rojekar M, 2016, TURK J ENDOCRINOL ME, V20, P83, DOI 10.4274/tjem.3586
   Sepahvand F, 2007, BASIC CLIN PHARMACOL, V101, P104, DOI 10.1111/j.1742-7843.2007.00080.x
   Shin BS, 2009, J KOREAN MED SCI, V24, P561, DOI 10.3346/jkms.2009.24.4.561
   Sumegová K, 2006, BIOLOGIA, V61, P699, DOI 10.2478/s11756-006-0143-4
   Tabur S, 2010, EUR J ENDOCRINOL, V162, P535, DOI 10.1530/EJE-09-0732
   van Himbergen TM, 2008, ATHEROSCLEROSIS, V199, P408, DOI 10.1016/j.atherosclerosis.2007.11.018
NR 30
TC 1
Z9 1
U1 0
U2 0
PU KRISHNA INST MEDICAL SCIENCES UNIV
PI MAHARASHTRA
PA MALKAPUR, KARAD, MAHARASHTRA, 415 539, INDIA
SN 2231-4261
J9 J KRISHNA INST MED S
JI J. Krishna Inst. Med. Sci. Univ.
PD OCT-DEC
PY 2023
VL 12
IS 4
BP 68
EP 80
PG 13
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA IN8L4
UT WOS:001167097700015
DA 2025-06-11
ER

PT J
AU Katsi, V
   Papakonstantinou, I
   Tsioufis, K
AF Katsi, Vasiliki
   Papakonstantinou, Ilias
   Tsioufis, Konstantinos
TI Atherosclerosis, Diabetes Mellitus, and Cancer: Common Epidemiology,
   Shared Mechanisms, and Future Management
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE lipoprotein metabolism; cancer metabolism; endothelial dysfunction;
   metabolic syndrome; oxidized lipids; oncogenic signals; autophagy;
   oxidative stress; adiposity; glycation; atherosclerosis
ID GLYCATION END-PRODUCTS; FATTY-ACID SYNTHASE; TOLL-LIKE RECEPTORS;
   ENDOTHELIAL GROWTH-FACTOR; HYPOXIA-INDUCIBLE FACTOR; LIVER X RECEPTORS;
   LIPID-METABOLISM; CARDIOVASCULAR-DISEASE; SIGNALING PATHWAYS; TUMOR
   ANGIOGENESIS
AB The involvement of cardiovascular disease in cancer onset and development represents a contemporary interest in basic science. It has been recognized, from the most recent research, that metabolic syndrome-related conditions, ranging from atherosclerosis to diabetes, elicit many pathways regulating lipid metabolism and lipid signaling that are also linked to the same framework of multiple potential mechanisms for inducing cancer. Otherwise, dyslipidemia and endothelial cell dysfunction in atherosclerosis may present common or even interdependent changes, similar to oncogenic molecules elevated in many forms of cancer. However, whether endothelial cell dysfunction in atherosclerotic disease provides signals that promote the pre-clinical onset and proliferation of malignant cells is an issue that requires further understanding, even though more questions are presented with every answer. Here, we highlight the molecular mechanisms that point to a causal link between lipid metabolism and glucose homeostasis in metabolic syndrome-related atherosclerotic disease with the development of cancer. The knowledge of these breakthrough mechanisms may pave the way for the application of new therapeutic targets and for implementing interventions in clinical practice.
C1 [Katsi, Vasiliki; Tsioufis, Konstantinos] Hippokrateion Hosp, Dept Cardiol, Athens 11527, Greece.
   [Papakonstantinou, Ilias] Evangelismos Med Ctr, Dept Internal Med 4, Athens 10676, Greece.
   [Tsioufis, Konstantinos] Natl & Kapodistrian Univ Athens, Sch Med, Athens 11527, Greece.
C3 Hippokration General Hospital; Evangelismos Hospital; National &
   Kapodistrian University of Athens; Athens Medical School
RP Katsi, V (corresponding author), Hippokrateion Hosp, Dept Cardiol, Athens 11527, Greece.
EM vkkatsi@yahoo.gr; iliaspapacon@yahoo.gr; ktsioufis@gmail.com
RI Papakonstantinou, Ilias/AAC-5703-2022
CR Abbate A, 2020, CIRC RES, V126, P1260, DOI 10.1161/CIRCRESAHA.120.315937
   Acker T, 2003, CELL TISSUE RES, V314, P145, DOI 10.1007/s00441-003-0763-8
   Ahmad S, 2018, SEMIN CANCER BIOL, V49, P44, DOI 10.1016/j.semcancer.2017.07.001
   Ahmed A, 2011, CURR OPIN LIPIDOL, V22, P380, DOI 10.1097/MOL.0b013e32834b26b3
   Akhmedov A, 2021, EUR HEART J, V42, P1797, DOI 10.1093/eurheartj/ehaa770
   Akoumianakis I, 2022, NAT REV CARDIOL, V19, P783, DOI 10.1038/s41569-022-00718-5
   Alannan M, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11244132
   Alfaddagh A, 2020, AM J PREVENT CARDIOL, V4, DOI 10.1016/j.ajpc.2020.100130
   Amaravadi RK, 2011, CLIN CANCER RES, V17, P654, DOI 10.1158/1078-0432.CCR-10-2634
   Amini M, 2021, BMC PUBLIC HEALTH, V21, DOI 10.1186/s12889-021-10429-0
   Aminzadeh M, 2018, INT IMMUNOPHARMACOL, V54, P78, DOI 10.1016/j.intimp.2017.10.024
   Antonopoulos AS, 2012, CURR PHARM DESIGN, V18, P1519
   Antunes P, 2022, MOLECULES, V27, DOI 10.3390/molecules27030991
   Apte RS, 2019, CELL, V176, P1248, DOI 10.1016/j.cell.2019.01.021
   Aragno M, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040385
   Ariano C, 2022, ANGIOGENESIS, V25, P471, DOI 10.1007/s10456-022-09840-x
   Aryal B, 2018, JCI INSIGHT, V3, DOI 10.1172/jci.insight.97918
   Ascenzi F, 2021, J EXP CLIN CANC RES, V40, DOI 10.1186/s13046-021-02067-6
   Aster JC, 2017, ANNU REV PATHOL-MECH, V12, P245, DOI 10.1146/annurev-pathol-052016-100127
   Auger C, 2019, MOL METAB, V29, P12, DOI 10.1016/j.molmet.2019.08.011
   Azizian-Farsani F, 2020, FRONT ONCOL, V10, DOI 10.3389/fonc.2020.552283
   Bai BC, 2020, CELL DEATH DIS, V11, DOI 10.1038/s41419-020-02985-x
   Balzan S, 2018, LIFE SCI, V198, P79, DOI 10.1016/j.lfs.2018.02.024
   Bardelcíková A, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12040901
   Barthelemy J, 2023, FRONT IMMUNOL, V14, DOI 10.3389/fimmu.2023.1083191
   Beckwitt CH, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0197422
   Belladelli F, 2022, CURR OPIN UROL, V32, P594, DOI 10.1097/MOU.0000000000001041
   Bergström G, 2021, CIRCULATION, V144, P916, DOI 10.1161/CIRCULATIONAHA.121.055340
   Biasizzo M, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.591803
   Billiard F, 2018, CELL REP, V22, P895, DOI 10.1016/j.celrep.2017.12.076
   Bilotta MT, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.584303
   Bitorina AV, 2019, BBA-MOL CELL BIOL L, V1864, DOI 10.1016/j.bbalip.2019.158518
   Blanco R, 2013, CSH PERSPECT MED, V3, DOI 10.1101/cshperspect.a006569
   Bojková B, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21114114
   Borrell-Pages M, 2014, ATHEROSCLEROSIS, V235, P363, DOI 10.1016/j.atherosclerosis.2014.05.922
   Boso D, 2019, THERANOSTICS, V9, P4860, DOI 10.7150/thno.35882
   Boucher P, 2020, ATHEROSCLEROSIS, V301, P15, DOI 10.1016/j.atherosclerosis.2020.03.024
   Bowden J, 2019, RES SYNTH METHODS, V10, P486, DOI 10.1002/jrsm.1346
   Briot A, 2015, J EXP MED, V212, P2147, DOI 10.1084/jem.20150603
   Budakoti M, 2021, CELL SIGNAL, V83, DOI 10.1016/j.cellsig.2021.109995
   Bui BP, 2022, CANCERS, V14, DOI 10.3390/cancers14246054
   Camaré C, 2017, REDOX BIOL, V12, P18, DOI 10.1016/j.redox.2017.01.007
   Cannizzaro L, 2017, NUTR METAB, V14, DOI 10.1186/s12986-016-0149-z
   Cantor JR, 2012, CANCER DISCOV, V2, P881, DOI 10.1158/2159-8290.CD-12-0345
   Carmeliet P, 2005, ONCOLOGY-BASEL, V69, P4, DOI 10.1159/000088478
   Carmeliet P, 2000, NAT MED, V6, P389, DOI 10.1038/74651
   Chae HS, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24010012
   Chandimali N, 2018, ANTICANCER RES, V38, P3967, DOI 10.21873/anticanres.12683
   Chen HM, 2021, ANTI-CANCER AGENT ME, V21, P2592, DOI 10.2174/1871520621666210201095613
   Chen X, 2021, NAT REV CLIN ONCOL, V18, P280, DOI 10.1038/s41571-020-00462-0
   Chen YP, 2021, NEOPLASMA, V68, P71, DOI 10.4149/neo_2020_200610N620
   Chen Z, 2014, CURR OPIN LIPIDOL, V25, P339, DOI 10.1097/MOL.0000000000000107
   Cheng CM, 2018, CANCER COMMUN, V38, DOI 10.1186/s40880-018-0301-4
   Cheng R, 2015, REV ENDOCR METAB DIS, V16, P67, DOI 10.1007/s11154-015-9310-7
   Cheung J.Y, 2011, T AM CLIN CLIMATOL A, V128, P308
   Chiang SK, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10092401
   Cho DI, 2023, EXP MOL MED, V55, P426, DOI 10.1038/s12276-023-00937-x
   Chou WC, 2022, CELL MOL IMMUNOL, V19, P337, DOI 10.1038/s41423-021-00780-y
   Clément AA, 2022, J PHYSIOL BIOCHEM, V78, P527, DOI 10.1007/s13105-021-00855-4
   Cypess AM, 2022, NEW ENGL J MED, V386, P768, DOI 10.1056/NEJMra2032804
   D'Assoro AB, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23116241
   Dabravolski SA, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020931
   Dabrowski M, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22041680
   Dalla Sega FV, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.01130
   De Bock K, 2013, CELL, V154, P651, DOI 10.1016/j.cell.2013.06.037
   De Nicola GM, 2011, NATURE, V475, P106, DOI 10.1038/nature10189
   de Vries MR, 2019, J INTERN MED, V285, P59, DOI 10.1111/joim.12821
   DeBose-Boyd RA, 2018, TRENDS BIOCHEM SCI, V43, P358, DOI 10.1016/j.tibs.2018.01.005
   Debras C, 2022, PLOS MED, V19, DOI 10.1371/journal.pmed.1003950
   Deng CF, 2022, FRONT ONCOL, V12, DOI 10.3389/fonc.2022.803473
   Dey P, 2021, CANCER DISCOV, V11, P1067, DOI 10.1158/2159-8290.CD-20-1211
   Dicembrini I, 2020, ACTA DIABETOL, V57, P689, DOI 10.1007/s00592-020-01479-8
   Dinkova-Kostova AT, 2023, TRENDS PHARMACOL SCI, V44, P137, DOI 10.1016/j.tips.2022.12.003
   DiRenzo D, 2017, CIRC RES, V120, P624, DOI 10.1161/CIRCRESAHA.116.310091
   Dong SH, 2022, J EXP CLIN CANC RES, V41, DOI 10.1186/s13046-021-02229-6
   Dong Zhizhen, 2018, Oncotarget, V9, P12705, DOI 10.18632/oncotarget.24061
   Doronzo G, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.640061
   Duarte CW, 2017, JCO CLIN CANCER INFO, V1, DOI 10.1200/CCI.16.00071
   Dupaul-Chicoine J, 2015, IMMUNITY, V43, P751, DOI 10.1016/j.immuni.2015.08.013
   Duprat F, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24065082
   Eichner LJ, 2019, CELL METAB, V29, P285, DOI 10.1016/j.cmet.2018.10.005
   El-Far AH, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21103613
   Erkasap N, 2021, EXP THER MED, V21, DOI 10.3892/etm.2021.10032
   Esposito K, 2012, DIABETES CARE, V35, P2402, DOI 10.2337/dc12-0336
   Morales PE, 2017, J DIABETES RES, V2017, DOI 10.1155/2017/1789395
   Fan X, 2023, TRANSL RES, V255, P1, DOI 10.1016/j.trsl.2022.11.001
   Farnier M, 2014, ARCH CARDIOVASC DIS, V107, P58, DOI 10.1016/j.acvd.2013.10.007
   Faruqui T, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24010266
   Fasoulakis Z, 2020, ADV EXP MED BIOL, V1287, P169, DOI 10.1007/978-3-030-55031-8_11
   Fendt SM, 2020, CANCER DISCOV, V10, P1797, DOI 10.1158/2159-8290.CD-20-0844
   Feng S, 2017, ARTERIOSCL THROM VAS, V37, P2087, DOI 10.1161/ATVBAHA.117.309249
   Ference BA, 2017, EUR HEART J, V38, P2459, DOI 10.1093/eurheartj/ehx144
   Fernández-Hernando C, 2011, CURR OPIN LIPIDOL, V22, P86, DOI 10.1097/MOL.0b013e3283428d9d
   Ferro F, 2020, SEMIN CELL DEV BIOL, V98, P129, DOI 10.1016/j.semcdb.2019.05.029
   Filippini A, 2022, CANCERS, V14, DOI 10.3390/cancers14081929
   Fiordelisi A, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20071599
   Gao T, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24054996
   Garcia D, 2017, MOL CELL, V66, P789, DOI 10.1016/j.molcel.2017.05.032
   García M, 2021, J CLIN PHARMACOL, V61, P187, DOI 10.1002/jcph.1722
   Gebrie A, 2023, SAGE OPEN MED, V11, DOI 10.1177/20503121231157209
   Geltinger F, 2020, MOLECULES, V25, DOI 10.3390/molecules25215053
   Gimbrone MA, 2013, CARDIOVASC PATHOL, V22, P9, DOI 10.1016/j.carpath.2012.06.006
   Goel HL, 2013, NAT REV CANCER, V13, P871, DOI 10.1038/nrc3627
   Goldstein JL, 2006, CELL, V124, P35, DOI 10.1016/j.cell.2005.12.022
   Gonzalez-Perez RR, 2010, CELL SIGNAL, V22, P1350, DOI 10.1016/j.cellsig.2010.05.003
   Goto A, 2020, INT J CANCER, V146, P712, DOI 10.1002/ijc.32310
   Graupera M, 2018, TRENDS ENDOCRIN MET, V29, P781, DOI 10.1016/j.tem.2018.09.003
   Greten FR, 2019, IMMUNITY, V51, P27, DOI 10.1016/j.immuni.2019.06.025
   Gugnoni M, 2016, CELL DEATH DIS, V7, DOI 10.1038/cddis.2016.415
   Guo Y, 2012, PHYSIOL RES, V61, P337, DOI 10.33549/physiolres.932289
   Gupta SC, 2012, ANTIOXID REDOX SIGN, V16, P1295, DOI 10.1089/ars.2011.4414
   Hagberg CE, 2010, NATURE, V464, P917, DOI 10.1038/nature08945
   Hamarsheh S, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.01444
   Han ZL, 2022, CELL DEATH DISCOV, V8, DOI 10.1038/s41420-022-01241-9
   Hanahan D, 2022, CANCER DISCOV, V12, P31, DOI 10.1158/2159-8290.CD-21-1059
   Handy CE, 2018, CIRCULATION, V138, P727, DOI 10.1161/CIRCULATIONAHA.118.035516
   Harris IS, 2020, TRENDS CELL BIOL, V30, P440, DOI 10.1016/j.tcb.2020.03.002
   Heiden MGV, 2009, SCIENCE, V324, P1029, DOI 10.1126/science.1160809
   Hirsch HA, 2010, CANCER CELL, V17, P348, DOI 10.1016/j.ccr.2010.01.022
   Hoeben A, 2004, PHARMACOL REV, V56, P549, DOI 10.1124/pr.56.4.3
   Hokkanen K, 2019, CURR OPIN LIPIDOL, V30, P370, DOI 10.1097/MOL.0000000000000626
   Hopkins BD, 2020, NAT REV ENDOCRINOL, V16, P276, DOI 10.1038/s41574-020-0329-9
   Hoxhaj G, 2020, NAT REV CANCER, V20, P74, DOI 10.1038/s41568-019-0216-7
   Hsu CC, 2022, SEMIN CANCER BIOL, V85, P52, DOI 10.1016/j.semcancer.2021.04.006
   Hu F, 2014, PROTEIN CELL, V5, P21, DOI 10.1007/s13238-013-0002-3
   Hu LL, 2023, J BIOL CHEM, V299, DOI 10.1016/j.jbc.2023.104570
   Huang BL, 2020, NAT METAB, V2, P132, DOI 10.1038/s42255-020-0174-0
   Huang ZG, 2018, P NATL ACAD SCI USA, V115, pE9499, DOI 10.1073/pnas.1806635115
   Incalza MA, 2018, VASC PHARMACOL, V100, P1, DOI 10.1016/j.vph.2017.05.005
   Iqbal J, 2018, CURR DIABETES REV, V14, P427, DOI 10.2174/1573399813666170705161039
   Jain T, 2018, PHARMACOL THERAPEUT, V183, P22, DOI 10.1016/j.pharmthera.2017.09.003
   Janssen JAMJL, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22157797
   Jaramillo MC, 2013, GENE DEV, V27, P2179, DOI 10.1101/gad.225680.113
   Jászai J, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8091102
   Jin Y, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.119.012219
   Kafyra M, 2023, NUTRIENTS, V15, DOI 10.3390/nu15081884
   Kang R, 2014, MOL ASPECTS MED, V40, P1, DOI 10.1016/j.mam.2014.05.001
   Karasawa T, 2017, J ATHEROSCLER THROMB, V24, P443, DOI 10.5551/jat.RV17001
   Kashani B, 2021, J CELL PHYSIOL, V236, P4121, DOI 10.1002/jcp.30166
   Katoh M, 2022, ESSAYS BIOCHEM, V66, P319, DOI 10.1042/EBC20220016
   Keerthana CK, 2023, FRONT IMMUNOL, V14, DOI 10.3389/fimmu.2023.1114582
   Khalid M, 2022, BIOMOLECULES, V12, DOI 10.3390/biom12040542
   Kim EJ, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00313
   Kishimoto Y, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20153628
   Koene RJ, 2016, CIRCULATION, V133, P1104, DOI 10.1161/CIRCULATIONAHA.115.020406
   Kong P, 2022, SIGNAL TRANSDUCT TAR, V7, DOI 10.1038/s41392-022-00955-7
   Kwon RJ, 2021, LIPIDS HEALTH DIS, V20, DOI 10.1186/s12944-021-01539-0
   Lacroix M, 2020, MOL METAB, V33, P2, DOI 10.1016/j.molmet.2019.10.002
   Lau ES, 2021, JACC-CARDIOONCOL, V3, P48, DOI 10.1016/j.jaccao.2020.12.003
   Lauby-Secretan B, 2016, NEW ENGL J MED, V375, P794, DOI 10.1056/NEJMsr1606602
   Lawrence MS, 2014, NATURE, V505, P495, DOI 10.1038/nature12912
   Lechner K, 2020, EUR J PREV CARDIOL, V27, P394, DOI 10.1177/2047487319869400
   Lee CC, 2012, NAT REV IMMUNOL, V12, P168, DOI 10.1038/nri3151
   Lee J, 2011, ATHEROSCLEROSIS, V215, P281, DOI 10.1016/j.atherosclerosis.2011.01.003
   Lee JY, 2006, MOL CELLS, V21, P174
   Lee SD, 2015, ATHEROSCLEROSIS, V242, P29, DOI 10.1016/j.atherosclerosis.2015.06.042
   Lengyel E, 2018, TRENDS CANCER, V4, P374, DOI 10.1016/j.trecan.2018.03.004
   Lewis CA, 2015, ONCOGENE, V34, P5128, DOI 10.1038/onc.2014.439
   Li S, 2016, ONCOGENE, V35, P642, DOI 10.1038/onc.2015.123
   Li WD, 2015, ONCOTARGET, V6, P7365, DOI 10.18632/oncotarget.3629
   Li XJ, 2017, AUTOPHAGY, V13, P1790, DOI 10.1080/15548627.2017.1349581
   Li XR, 2019, CELL METAB, V30, P414, DOI 10.1016/j.cmet.2019.08.011
   Li YK, 2023, FRONT PHARMACOL, V14, DOI 10.3389/fphar.2023.1130747
   Li ZW, 2021, CELL METAB, V33, P78, DOI 10.1016/j.cmet.2020.12.011
   Liao D, 2007, CANCER METAST REV, V26, P281, DOI 10.1007/s10555-007-9066-y
   Libby P, 2021, NATURE, V592, P524, DOI 10.1038/s41586-021-03392-8
   Libby P, 2019, NAT REV DIS PRIMERS, V5, DOI [10.1038/s41572-019-0106-z, 10.1038/s41572-019-0116-x]
   Liberale L, 2020, INT J BIOCHEM CELL B, V122, DOI 10.1016/j.biocel.2020.105735
   Lim JH, 2014, ANTICANCER RES, V34, P4087
   Lin CY, 2015, NAT REV CANCER, V15, P216, DOI 10.1038/nrc3912
   Lin SC, 2018, CELL METAB, V27, P299, DOI 10.1016/j.cmet.2017.10.009
   Ling R, 2022, DISCOV ONCOL, V13, DOI 10.1007/s12672-022-00521-1
   Liu MY, 2022, FREE RADICAL BIO MED, V182, P219, DOI 10.1016/j.freeradbiomed.2022.03.002
   Liu Q, 2021, MOL MED REP, V24, DOI 10.3892/mmr.2021.12348
   Liu W, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-25354-4
   Liu XJ, 2020, NATURE, V588, P693, DOI 10.1038/s41586-020-2911-7
   Liu ZZ, 2022, LIFE SCI, V294, DOI 10.1016/j.lfs.2022.120370
   Loboda A, 2016, CELL MOL LIFE SCI, V73, P3221, DOI 10.1007/s00018-016-2223-0
   López M, 2018, EUR J CLIN INVEST, V48, DOI 10.1111/eci.12996
   Lu B, 2023, J GASTROEN HEPATOL, V38, P187, DOI 10.1111/jgh.16042
   Lu HC, 2021, EBIOMEDICINE, V63, DOI 10.1016/j.ebiom.2020.103207
   Luo WQ, 2022, INT J BIOL SCI, V18, P6020, DOI 10.7150/ijbs.74902
   Lv X, 2017, GENES DIS, V4, P19, DOI 10.1016/j.gendis.2016.11.003
   Mahboobnia K, 2021, BIOMED PHARMACOTHER, V140, DOI 10.1016/j.biopha.2021.111758
   Mansouri A, 2022, J CLIN MED, V11, DOI 10.3390/jcm11051313
   Marmé D, 2018, ONCOL RES TREAT, V41, P164, DOI 10.1159/000488340
   Martínez-Reyes I, 2021, NAT REV CANCER, V21, P669, DOI 10.1038/s41568-021-00378-6
   Matta L, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11091689
   McAllister SS, 2010, J CLIN ONCOL, V28, P4022, DOI 10.1200/JCO.2010.28.4257
   McCall KD, 2020, ADV EXP MED BIOL, V1223, P81, DOI 10.1007/978-3-030-35582-1_5
   Melton E, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22168639
   Menendez JA, 2009, CLIN CHEM, V55, P425, DOI 10.1373/clinchem.2008.115352
   Meyers AK, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9081808
   Mili N, 2021, ENDOCRINE, V74, P478, DOI 10.1007/s12020-021-02884-x
   Mitsuishi Y, 2012, CANCER CELL, V22, P66, DOI 10.1016/j.ccr.2012.05.016
   Mizuno S, 2022, J CANCER RES CLIN, V148, P1351, DOI 10.1007/s00432-022-03960-z
   Moessinger C, 2020, EMBO REP, V21, DOI 10.15252/embr.201949343
   Momtazi-Borojeni AA, 2019, EUR HEART J-CARD PHA, V5, P237, DOI 10.1093/ehjcvp/pvz022
   Moon SH, 2019, CELL, V176, P564, DOI 10.1016/j.cell.2018.11.011
   Moore KJ, 2011, ANNU REV NUTR, V31, P49, DOI 10.1146/annurev-nutr-081810-160756
   Morales A, 2021, LAB INVEST, V101, P921, DOI 10.1038/s41374-021-00583-9
   Moukarzel LA, 2022, CANCER-AM CANCER SOC, V128, P3297, DOI 10.1002/cncr.34356
   Mu WJ, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222111512
   Mukherjee A, 2022, CANCER METAST REV, V41, P575, DOI 10.1007/s10555-022-10059-x
   Mukwaya A, 2021, EXP MOL MED, V53, P189
   Mullen PJ, 2016, NAT REV CANCER, V16, P718, DOI 10.1038/nrc.2016.76
   Murdocca M, 2021, CANCER GENE THER, V28, P1088, DOI 10.1038/s41417-020-00279-0
   Murphy N, 2022, JNCI-J NATL CANCER I, V114, P740, DOI 10.1093/jnci/djac011
   Nagao A, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20020238
   Najafi-Shoushtari SH, 2010, SCIENCE, V328, P1566, DOI 10.1126/science.1189123
   Nam GH, 2021, J IMMUNOTHER CANCER, V9, DOI 10.1136/jitc-2021-002474
   Nath A, 2015, SCI REP-UK, V5, DOI 10.1038/srep14752
   Neshat S, 2022, J RES MED SCI, V27, DOI 10.4103/jrms.jrms_267_22
   Ntellas P, 2020, CANCERS, V12, DOI 10.3390/cancers12113145
   Nusse R, 2017, CELL, V169, P985, DOI 10.1016/j.cell.2017.05.016
   Occhiuto CJ, 2023, MOL CELLS, V46, P176, DOI 10.14348/molcells.2023.2191
   Oeckl J, 2022, MOL METAB, V61, DOI 10.1016/j.molmet.2022.101499
   Olzmann JA, 2019, NAT REV MOL CELL BIO, V20, P137, DOI 10.1038/s41580-018-0085-z
   Ott C, 2014, REDOX BIOL, V2, P411, DOI 10.1016/j.redox.2013.12.016
   Overbeek JA, 2018, DIABETES-METAB RES, V34, DOI 10.1002/dmrr.3004
   Oza PP, 2023, EUR J PHARMACOL, V949, DOI 10.1016/j.ejphar.2023.175721
   Palanissami G, 2018, HORM CANCER-US, V9, P295, DOI 10.1007/s12672-018-0342-9
   Pallegar NK, 2020, ADV EXP MED BIOL, V1234, P1, DOI 10.1007/978-3-030-37184-5_1
   Pandrangi SL, 2022, MEMBRANES-BASEL, V12, DOI 10.3390/membranes12050532
   Panieri E, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9030193
   Patel SA, 2023, CLIN CANCER RES, V29, P30, DOI 10.1158/1078-0432.CCR-22-1366
   Pati S, 2023, CANCERS, V15, DOI 10.3390/cancers15020485
   Pearson-Stuttard J, 2021, CANCER EPIDEM BIOMAR, V30, P1218, DOI 10.1158/1055-9965.EPI-20-1245
   Peck B, 2019, TRENDS CANCER, V5, P693, DOI 10.1016/j.trecan.2019.09.007
   Peng CY, 2019, LIPIDS HEALTH DIS, V18, DOI 10.1186/s12944-019-1125-1
   Petan T, 2023, REV PHYSIOL BIOCH P, V185, P53, DOI 10.1007/112_2020_51
   Pezzuto A, 2018, CURR MOL MED, V18, P343, DOI 10.2174/1566524018666181109121849
   Pfeffer TJ, 2020, HERZ, V45, P632, DOI 10.1007/s00059-020-04953-9
   Piccinin E, 2021, MOL ASPECTS MED, V78, DOI 10.1016/j.mam.2020.100933
   Piccoli GF, 2021, J CLIN ENDOCR METAB, V106, P912, DOI 10.1210/clinem/dgaa891
   Pirmoradi L, 2019, J INVEST MED, V67, P715, DOI 10.1136/jim-2018-000962
   Plein A, 2014, MICROCIRCULATION, V21, P315, DOI 10.1111/micc.12124
   Pons-Tostivint E, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10113129
   Pouremamali F, 2022, CELL COMMUN SIGNAL, V20, DOI 10.1186/s12964-022-00906-3
   Prasad C, 2014, AGING DIS, V5, P212, DOI 10.14336/AD.2014.0500212
   Qi SY, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23136934
   Quan MX, 2022, CIRC RES, V131, P748, DOI 10.1161/CIRCRESAHA.122.321322
   Radtke F, 2010, IMMUNITY, V32, P14, DOI 10.1016/j.immuni.2010.01.004
   Rana JS, 2021, J GEN INTERN MED, V36, P2517, DOI 10.1007/s11606-020-06070-z
   Ravaut G, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22010330
   Ren Q, 2021, FRONT CELL DEV BIOL, V9, DOI 10.3389/fcell.2021.670960
   Renehan AG, 2008, LANCET, V371, P569, DOI 10.1016/S0140-6736(08)60269-X
   Revathidevi S, 2019, SEMIN CANCER BIOL, V59, P80, DOI 10.1016/j.semcancer.2019.06.002
   Ricard N, 2021, NAT REV CARDIOL, V18, P565, DOI 10.1038/s41569-021-00517-4
   Ricciuti B, 2019, SEMIN CANCER BIOL, V56, P87, DOI 10.1016/j.semcancer.2017.11.005
   Roshan MHK, 2016, INT J INFLAMM, V2016, DOI 10.1155/2016/1532832
   Roth GA, 2020, J AM COLL CARDIOL, V76, P2980, DOI 10.1016/j.jacc.2020.11.021
   Roy PS, 2016, INDIAN J CANCER, V53, P441, DOI 10.4103/0019-509X.200658
   Royo-Garcia A, 2021, WORLD J STEM CELLS, V13, DOI 10.4252/wjsc.v13.i9.1307
   Sabatini DM, 2017, P NATL ACAD SCI USA, V114, P11818, DOI 10.1073/pnas.1716173114
   Sadeghi M, 2023, CURR MED CHEM, V30, P1623, DOI 10.2174/0929867329666220817142848
   Saharinen P, 2017, NAT REV DRUG DISCOV, V16, P635, DOI 10.1038/nrd.2016.278
   Saikia R, 2021, J MOL MED, V99, P1539, DOI 10.1007/s00109-021-02125-8
   Saravia J, 2020, CELL RES, V30, P328, DOI 10.1038/s41422-020-0301-1
   Sarzani R, 2011, NUTR METAB CARDIOVAS, V21, P150, DOI 10.1016/j.numecd.2009.08.004
   Sayin VI, 2019, TRENDS CANCER, V5, P457, DOI 10.1016/j.trecan.2019.06.001
   Sazaki I, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24054281
   Scalise V, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222312640
   Schiano C, 2021, FOOD RES INT, V142, DOI 10.1016/j.foodres.2021.110220
   Schröter D, 2018, CURR PHARM DESIGN, V24, P5245, DOI 10.2174/1381612825666190130145549
   Scully T, 2021, FRONT ONCOL, V10, DOI 10.3389/fonc.2020.615375
   Seidah NG, 2022, CURR ATHEROSCLER REP, V24, P821, DOI 10.1007/s11883-022-01057-z
   Seidah NG, 2021, ENDOCR REV, V43, P558, DOI 10.1210/endrev/bnab035
   Seki T, 2022, NATURE, V608, P421, DOI 10.1038/s41586-022-05030-3
   Sen P, 2023, ACS PHARMACOL TRANSL, V6, P651, DOI 10.1021/acsptsci.2c00239
   Settembre C, 2013, NAT CELL BIOL, V15, P647, DOI 10.1038/ncb2718
   Shackelford DB, 2009, NAT REV CANCER, V9, P563, DOI 10.1038/nrc2676
   Shah AA, 2021, CURR DRUG METAB, V22, P50, DOI 10.2174/1389200221666201019143252
   Shahab U, 2018, SEMIN CANCER BIOL, V49, P37, DOI 10.1016/j.semcancer.2017.07.010
   Sharma BR, 2021, NAT IMMUNOL, V22, P550, DOI 10.1038/s41590-021-00886-5
   Sheedy FJ, 2013, NAT IMMUNOL, V14, P812, DOI 10.1038/ni.2639
   Shum HCE, 2023, J PERS MED, V13, DOI 10.3390/jpm13010157
   Rossi JLS, 2022, DIABETES-METAB RES, V38, DOI 10.1002/dmrr.3502
   Singh R, 2013, HUM MUTAT, V34, P1221, DOI 10.1002/humu.22360
   Soehnlein O, 2021, NAT REV DRUG DISCOV, V20, P589, DOI 10.1038/s41573-021-00198-1
   Solimando AG, 2020, CANCERS, V12, DOI 10.3390/cancers12113380
   Sondergaard CS, 2023, CURR ONCOL REP, V25, P29, DOI 10.1007/s11912-022-01344-7
   Song TY, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/4824371
   Steinberg GR, 2023, NAT REV MOL CELL BIO, V24, P255, DOI 10.1038/s41580-022-00547-x
   Stork BA, 2022, MOL METAB, V62, DOI 10.1016/j.molmet.2022.101513
   Su XS, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/5549047
   Sun JJ, 2021, ARTERIOSCL THROM VAS, V41, P783, DOI 10.1161/ATVBAHA.120.315310
   Sun M, 2023, JNCI-J NATL CANCER I, V115, P456, DOI 10.1093/jnci/djad008
   Sun N, 2016, MOL CELL, V61, P654, DOI 10.1016/j.molcel.2016.01.028
   Sung H, 2021, CA-CANCER J CLIN, V71, P209, DOI 10.3322/caac.21660
   Tabas I, 2017, IMMUNITY, V47, P621, DOI 10.1016/j.immuni.2017.09.008
   Takeuchi M, 2020, DIABETOL METAB SYNDR, V12, DOI 10.1186/s13098-020-00614-3
   Tan A, 2022, CELL DEATH DIFFER, V29, P1433, DOI 10.1038/s41418-022-01028-6
   Tang ZH, 2017, ATHEROSCLEROSIS, V262, P113, DOI 10.1016/j.atherosclerosis.2017.04.023
   Tavazoie MF, 2018, CELL, V172, P825, DOI 10.1016/j.cell.2017.12.026
   Taylor AE, 2014, ECON HUM BIOL, V13, P99, DOI 10.1016/j.ehb.2013.12.002
   Teleanu RI, 2020, J CLIN MED, V9, DOI 10.3390/jcm9010084
   Tesfay L, 2019, CANCER RES, V79, P5355, DOI 10.1158/0008-5472.CAN-19-0369
   Theelen TL, 2015, ATHEROSCLEROSIS, V241, P297, DOI 10.1016/j.atherosclerosis.2015.05.018
   Thomas C, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.868958
   Timmis A, 2020, EUR HEART J, V41, P12, DOI 10.1093/eurheartj/ehz859
   Trefts E, 2021, MOL CELL, V81, P3677, DOI 10.1016/j.molcel.2021.08.015
   Tsakogiannis D, 2021, MEDICINA-LITHUANIA, V57, DOI 10.3390/medicina57111191
   Tsumita T, 2022, INT J CANCER, V151, P944, DOI 10.1002/ijc.34134
   Twarda-Clapa A, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11081312
   Urban-Wojciuk Z, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.02388
   Vallée A, 2021, CANCERS, V13, DOI 10.3390/cancers13215557
   Vanauberg D, 2023, ONCOGENESIS, V12, DOI 10.1038/s41389-023-00460-8
   Vara-Ciruelos D, 2019, OPEN BIOL, V9, DOI 10.1098/rsob.190099
   Vazquez-Martin A, 2008, CELL PROLIFERAT, V41, P59, DOI 10.1111/j.1365-2184.2007.00498.x
   Vijay K, 2018, INT IMMUNOPHARMACOL, V59, P391, DOI 10.1016/j.intimp.2018.03.002
   Vincent L, 2019, CURR ONCOL REP, V21, DOI 10.1007/s11912-019-0796-0
   Virani SS, 2020, CIRCULATION, V141, pE139, DOI 10.1161/CIR.0000000000000757
   Tapia-Vieyra JV, 2017, ARCH MED RES, V48, P12, DOI 10.1016/j.arcmed.2017.03.005
   Vlassara H, 2011, NAT REV ENDOCRINOL, V7, P526, DOI 10.1038/nrendo.2011.74
   Wan SC, 2023, CELL COMMUN SIGNAL, V21, DOI 10.1186/s12964-023-01108-1
   Wang DD, 2019, PHARMACOL REV, V71, P596, DOI 10.1124/pr.118.017178
   Wang HC, 2023, CELLS-BASEL, V12, DOI 10.3390/cells12010046
   Wang H, 2020, ONCOL REP, V44, P174, DOI 10.3892/or.2020.7586
   Wang JC, 2019, THERANOSTICS, V9, P4893, DOI 10.7150/thno.36037
   Wang SH, 2014, BIOFACTORS, V40, P547, DOI 10.1002/biof.1187
   Wang XX, 2017, CANCER RES, V77, P4947, DOI 10.1158/0008-5472.CAN-17-0114
   Wang Y, 2014, BLOOD, V124, P1127, DOI 10.1182/blood-2013-12-544221
   Wang ZY, 2016, EXPERIENTIA SUPPL, V107, P203, DOI 10.1007/978-3-319-43589-3_9
   Wardyn JD, 2015, BIOCHEM SOC T, V43, P621, DOI 10.1042/BST20150014
   Weinberg F, 2019, CANCERS, V11, DOI 10.3390/cancers11081191
   White U, 2023, FRONT CELL DEV BIOL, V11, DOI 10.3389/fcell.2023.1188844
   Wu FL, 2021, SIGNAL TRANSDUCT TAR, V6, DOI 10.1038/s41392-021-00641-0
   Wu XN, 2020, ISCIENCE, V23, DOI 10.1016/j.isci.2020.101569
   Xie JL, 2013, CELL SIGNAL, V25, P2185, DOI 10.1016/j.cellsig.2013.06.013
   Xu HJ, 2020, BBA-REV CANCER, V1874, DOI 10.1016/j.bbcan.2020.188394
   Xu SW, 2021, PHARMACOL REV, V73, P924, DOI 10.1124/pharmrev.120.000096
   Yarmolinsky J, 2018, CANCER EPIDEM BIOMAR, V27, P995, DOI [10.1158/1055-9965.EPI-17-1177, 10.1158/1055-9965.epi-17-1177]
   Yeh YH, 2018, J EXP CLIN CANC RES, V37, DOI 10.1186/s13046-018-0730-6
   Yi JM, 2020, P NATL ACAD SCI USA, V117, P31189, DOI 10.1073/pnas.2017152117
   Yin SS, 2018, MOL MED REP, V18, P2798, DOI 10.3892/mmr.2018.9236
   Yu H, 2020, SIGNAL TRANSDUCT TAR, V5, DOI 10.1038/s41392-020-00312-6
   Yuan S, 2020, DIABETES, V69, P1588, DOI 10.2337/db20-0084
   Yue W, 2019, IUBMB LIFE, V71, P1347, DOI 10.1002/iub.2046
   Zabirnyk O, 2010, CARCINOGENESIS, V31, P446, DOI 10.1093/carcin/bgp299
   Zadra G, 2015, MOL CANCER RES, V13, P1059, DOI 10.1158/1541-7786.MCR-15-0068
   Zalpoor H, 2022, CELL COMMUN SIGNAL, V20, DOI 10.1186/s12964-022-00951-y
   Zhang RS, 2022, EUR J MED CHEM, V230, DOI 10.1016/j.ejmech.2022.114111
   Zhang Run, 2023, Biochem Biophys Res Commun, V651, P8, DOI 10.1016/j.bbrc.2023.02.007
   Zhang ZH, 2022, FRONT ONCOL, V12, DOI 10.3389/fonc.2022.1024789
   Zhao HK, 2021, SIGNAL TRANSDUCT TAR, V6, DOI 10.1038/s41392-021-00658-5
   Zhao JY, 2020, SIGNAL TRANSDUCT TAR, V5, DOI 10.1038/s41392-020-0132-z
   Zhao ZW, 2021, ATHEROSCLEROSIS, V327, P76, DOI 10.1016/j.atherosclerosis.2021.04.002
   Zhong L, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1116582
   Zhou BH, 2022, SIGNAL TRANSDUCT TAR, V7, DOI 10.1038/s41392-022-00934-y
   Zhou Y, 2023, CURR PHARM BIOTECHNO, V24, P253, DOI 10.2174/1389201023666220506105026
   Zhou ZY, 2023, FRONT ONCOL, V12, DOI 10.3389/fonc.2022.1080054
NR 352
TC 14
Z9 14
U1 2
U2 12
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL
PY 2023
VL 24
IS 14
AR 11786
DI 10.3390/ijms241411786
PG 41
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA N3FN5
UT WOS:001035913300001
PM 37511551
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ntamo, Y
   Jack, B
   Ziqubu, K
   Mazibuko-Mbeje, SE
   Nkambule, BB
   Nyambuya, TM
   Mabhida, SE
   Hanser, S
   Orlando, P
   Tiano, L
   Dludla, P
AF Ntamo, Yonela
   Jack, Babalwa
   Ziqubu, Khanyisani
   Mazibuko-Mbeje, Sithandiwe E.
   Nkambule, Bongani B.
   Nyambuya, Tawanda M.
   Mabhida, Sihle E.
   Hanser, Sidney
   Orlando, Patrick
   Tiano, Luca
   Dludla, Phiwayinkosi, V
TI Epigallocatechin gallate as a nutraceutical to potentially target the
   metabolic syndrome: novel insights into therapeutic effects beyond its
   antioxidant and anti-inflammatory properties
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Antioxidants; epigallocatechin gallate; green tea; inflammation;
   metabolic syndrome; nutraceuticals
ID GREEN TEA EXTRACT; CATECHOL-O-METHYLTRANSFERASE; RISK-FACTORS;
   POLYPHENOL EPIGALLOCATECHIN-3-GALLATE; (-)-EPIGALLOCATECHIN GALLATE;
   INSULIN-RESISTANCE; HYDROGEN-PEROXIDE; OXIDATIVE STRESS; FAT OXIDATION;
   DOUBLE-BLIND
AB Epigallocatechin gallate (EGCG) is one of the most abundant and powerful flavonoids contained in green tea. Because of the global increase in green tea consumption, there has been a general interest in understanding its health benefits, including its bioactive compounds like EGCG. Indeed, preclinical evidence already indicates that EGCG demonstrated a strong antioxidant and anti-inflammatory properties that could be essential in protecting against metabolic syndrome. The current review explores clinical evidence reporting on the beneficial effects of EGCG supplementation in obese subjects or patients with diverse metabolic complications that include type 2 diabetes and cardiovascular disease. The discussion incorporates the impact of different formulations of EGCG, as well as the effective doses and treatment duration. Importantly, besides highlighting the potential use of EGCG as a nutraceutical, the current review also discusses crucial evidence related to its pharmaceutical development as an agent to hinder metabolic diseases, including its bioavailability and metabolism profile, as well as its well-known biological properties.
C1 [Ntamo, Yonela; Jack, Babalwa; Mabhida, Sihle E.; Dludla, Phiwayinkosi, V] South African Med Res Council, Biomed Res & Innovat Platform, Tygerberg, South Africa.
   [Ziqubu, Khanyisani; Mazibuko-Mbeje, Sithandiwe E.] North West Univ, Dept Biochem, Mmabatho, South Africa.
   [Nkambule, Bongani B.] Univ KwaZulu Natal, Sch Lab Med & Med Sci, Durban, South Africa.
   [Nyambuya, Tawanda M.] Namibia Univ Sci & Technol, Dept Hlth Sci, Windhoek, Namibia.
   [Hanser, Sidney] Univ Limpopo, Dept Physiol & Environm Hlth, Sovenga, South Africa.
   [Orlando, Patrick; Tiano, Luca] Polytech Univ Marche, Dept Life & Environm Sci, Ancona, Italy.
   [Dludla, Phiwayinkosi, V] Univ Zululand, Dept Biochem & Microbiol, Kwa Dlangezwa, South Africa.
C3 South African Medical Research Council; North West University - South
   Africa; University of Kwazulu Natal; Namibia University of Science &
   Technology; University of Limpopo; Marche Polytechnic University;
   University of Zululand
RP Dludla, P (corresponding author), South African Med Res Council, Biomed Res & Innovat Platform, Tygerberg, South Africa.; Dludla, P (corresponding author), Univ Zululand, Dept Biochem & Microbiol, Kwa Dlangezwa, South Africa.
RI Mazibuko-Mbeje, Sithandiwe/HPG-1119-2023; Nkambule,
   Bongani/ABD-7943-2022; Orlando, Patrick/LSJ-0851-2024; Nyambuya, Tawanda
   Maurice/GLU-4124-2022; Jack, Babalwa/LTF-1602-2024; Tiano,
   Luca/ABC-2341-2020
OI Nyambuya, Tawanda Maurice/0000-0002-3288-9524; Ziqubu,
   Khanyisani/0000-0002-1211-9688; Tiano, Luca/0000-0002-7519-7106;
   Mabhida, Sihle/0000-0002-8388-132X; Orlando,
   Patrick/0000-0002-4203-9611; Nkambule, Bongani/0000-0001-8846-1992;
   Hanser, Sidney/0000-0002-6719-8512
FU Biomedical Research and Innovation Platform of the South African Medical
   Research Council (SAMRC); National Research Foundation (NRF) of South
   Africa [117829]
FX This work was supported in part by baseline funding from the Biomedical
   Research and Innovation Platform of the South African Medical Research
   Council (SAMRC) and the National Research Foundation (NRF) of South
   Africa (Grant number: 117829). The content hereof is the sole
   responsibility of the authors and do not necessarily represent the
   official views of the SAMRC or the funders.
CR Aggarwal V, 2022, SEMIN CANCER BIOL, V80, P256, DOI 10.1016/j.semcancer.2020.05.011
   Alipour M, 2018, PROG NUTR, V20, P12, DOI 10.23751/pn.v20i1.6228
   Almatroodi SA, 2020, MOLECULES, V25, DOI 10.3390/molecules25143146
   Alomar MJ, 2014, SAUDI PHARM J, V22, P83, DOI 10.1016/j.jsps.2013.02.003
   Fernández VA, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9050440
   Arazi H, 2014, HIGH BLOOD PRESS CAR, V21, P213, DOI 10.1007/s40292-014-0048-1
   Awortwe C, 2014, J PHARM PHARM SCI, V17, P1, DOI 10.18433/J30K63
   Bae J., 2020, BIOMED DERMATOL, V4, DOI DOI 10.1186/S41702-020-0057-8
   Bajerska J, 2015, J MED FOOD, V18, P698, DOI 10.1089/jmf.2014.0032
   Basu A, 2011, NUTRITION, V27, P206, DOI 10.1016/j.nut.2010.01.015
   Basu A, 2010, J AM COLL NUTR, V29, P31, DOI 10.1080/07315724.2010.10719814
   Bazyar Hadi, 2020, J Complement Integr Med, V18, P405, DOI 10.1515/jcim-2020-0090
   Benlloch M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12123792
   Borges CM, 2016, SCI REP-UK, V6, DOI 10.1038/srep28282
   Boschmann M, 2007, J AM COLL NUTR, V26, p389S, DOI 10.1080/07315724.2007.10719627
   Boulmokh Y, 2021, STRUCT CHEM, V32, P1907, DOI 10.1007/s11224-021-01763-5
   Braegelmann C, 2022, J EUR ACAD DERMATOL, V36, P144, DOI 10.1111/jdv.17710
   Brewer MS, 2011, COMPR REV FOOD SCI F, V10, P221, DOI 10.1111/j.1541-4337.2011.00156.x
   Brown AL, 2011, BRIT J NUTR, V106, P1880, DOI 10.1017/S0007114511002376
   Brown AL, 2009, BRIT J NUTR, V101, P886, DOI 10.1017/S0007114508047727
   Byun EB, 2018, CELL PHYSIOL BIOCHEM, V46, P2072, DOI 10.1159/000489447
   Cai ZY, 2018, MOLECULES, V23, DOI 10.3390/molecules23092346
   Cazzola R, 2020, J MED FOOD, V23, P319, DOI 10.1089/jmf.2019.0145
   Cerbin-Koczorowska M, 2021, APPL SCI-BASEL, V11, DOI 10.3390/app11114905
   Ceriello A, 2022, LANCET DIABETES ENDO, V10, P75, DOI 10.1016/S2213-8587(21)00245-X
   Chatree S, 2021, EXP BIOL MED, V246, P163, DOI 10.1177/1535370220962708
   Chen IJ, 2016, CLIN NUTR, V35, P592, DOI 10.1016/j.clnu.2015.05.003
   Chen LS, 1997, DRUG METAB DISPOS, V25, P1045
   Chen ZM, 2015, J ZHEJIANG UNIV-SC B, V16, P87, DOI 10.1631/jzus.B1500001
   Chow HHS, 2011, PHARMACOL RES, V64, P105, DOI 10.1016/j.phrs.2011.05.007
   Chow HHS, 2005, CLIN CANCER RES, V11, P4627, DOI 10.1158/1078-0432.CCR-04-2549
   Chow HHS, 2003, CLIN CANCER RES, V9, P3312
   Chu ChenYu Chu ChenYu, 2017, BioMed Research International, V2017, P5615647, DOI 10.1155/2017/5615647
   Cione E, 2020, MOLECULES, V25, DOI 10.3390/molecules25010063
   Collado-Mateo D, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18042023
   Cory H, 2018, FRONT NUTR, V5, DOI 10.3389/fnut.2018.00087
   Dai WZ, 2020, J FUNCT FOODS, V65, DOI 10.1016/j.jff.2019.103732
   de la Torre R, 2020, CLIN NUTR, V39, P378, DOI 10.1016/j.clnu.2019.02.028
   de la Torre R, 2016, LANCET NEUROL, V15, P801, DOI 10.1016/S1474-4422(16)30034-5
   De la Torre R, 2014, MOL NUTR FOOD RES, V58, P278, DOI 10.1002/mnfr.201300325
   Dekant W, 2017, TOXICOL LETT, V277, P104, DOI 10.1016/j.toxlet.2017.06.008
   Dettlaff K, 2017, INT J MOL MED, V40, P329, DOI 10.3892/ijmm.2017.3024
   Dludla PV, 2021, CLIN NUTR ESPEN, V41, P77, DOI 10.1016/j.clnesp.2020.11.006
   Dludla PV, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010023
   Dostal AM, 2017, J HUM NUTR DIET, V30, P166, DOI 10.1111/jhn.12408
   Dostal AM, 2016, J NUTR, V146, P256, DOI 10.3945/jn.115.219238
   Elbling L, 2010, FREE RADICAL BIO MED, V49, P1444, DOI 10.1016/j.freeradbiomed.2010.08.008
   Ellis LZ, 2011, BIOCHEM BIOPH RES CO, V414, P551, DOI 10.1016/j.bbrc.2011.09.115
   Eng QY, 2018, J ETHNOPHARMACOL, V210, P296, DOI 10.1016/j.jep.2017.08.035
   Evageliou V, 2019, FOOD CHEM, V281, P171, DOI 10.1016/j.foodchem.2018.12.105
   Fernández-Garcia JC, 2013, CURR VASC PHARMACOL, V11, P906, DOI 10.2174/15701611113116660175
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Ferreira MA, 2016, OBES REV, V17, P1316, DOI 10.1111/obr.12452
   Fraga CG, 2019, FOOD FUNCT, V10, P514, DOI [10.1039/c8fo01997e, 10.1039/C8FO01997E]
   Fu M, 2017, INT IMMUNOPHARMACOL, V49, P102, DOI 10.1016/j.intimp.2017.05.030
   Gan RY, 2018, CRIT REV FOOD SCI, V58, P924, DOI 10.1080/10408398.2016.1231168
   Gandhi M, 2004, ANNU REV PHARMACOL, V44, P499, DOI [10.1146/annurev.pharmtox.44.101802.121453, 10.2165/00003088-200948030-00001]
   Gloro R, 2005, EUR J GASTROEN HEPAT, V17, P1135, DOI 10.1097/00042737-200510000-00021
   Grassi D, 2013, AM J CLIN NUTR, V98, p1660S, DOI 10.3945/ajcn.113.058313
   Green RJ, 2007, MOL NUTR FOOD RES, V51, P1152, DOI 10.1002/mnfr.200700086
   Grundy SM, 2016, TRENDS CARDIOVAS MED, V26, P364, DOI 10.1016/j.tcm.2015.10.004
   Grzesik M, 2018, FOOD CHEM, V241, P480, DOI 10.1016/j.foodchem.2017.08.117
   Guo TT, 2019, FOOD SCI BIOTECHNOL, V28, P1617, DOI 10.1007/s10068-019-00656-y
   Han YC, 2020, J FOOD BIOCHEM, V44, DOI 10.1111/jfbc.13372
   Hayakawa S, 2020, MOLECULES, V25, DOI 10.3390/molecules25194553
   He JT, 2018, MED SCI MONITOR, V24, P8198, DOI 10.12659/MSM.911175
   Hill AM, 2007, J AM COLL NUTR, V26, p396S, DOI 10.1080/07315724.2007.10719628
   Hinojosa-Nogueira D, 2021, FOOD FUNCT, V12, P3799, DOI [10.1039/d1fo00261a, 10.1039/D1FO00261A]
   Hosseini S, 2021, ARCH MED SCI, V17, P1722, DOI 10.5114/aoms.2020.95903
   Hsu Chung-Hua, 2011, Altern Med Rev, V16, P157
   Hu J, 2018, REGUL TOXICOL PHARM, V95, P412, DOI 10.1016/j.yrtph.2018.03.019
   Huang J, 2014, EUR J CLIN NUTR, V68, P1075, DOI 10.1038/ejcn.2014.143
   Huang SM, 2013, MOL NUTR FOOD RES, V57, P2264, DOI 10.1002/mnfr.201300275
   Hung PF, 2005, AM J PHYSIOL-CELL PH, V288, pC1094, DOI 10.1152/ajpcell.00569.2004
   Hursel R, 2009, AM J CLIN NUTR, V89, P822, DOI 10.3945/ajcn.2008.27043
   Huseynov MB, 2021, B EXP BIOL MED+, V172, P143, DOI 10.1007/s10517-021-05351-9
   Hussain T, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/7432797
   International Diabetes Federation, 2022, IDF DIAB ATL 2021
   Kadowaki M, 2008, J PHARM PHARMACOL, V60, P1189, DOI 10.1211/jpp.60.9.0011
   Kale A, 2010, PHYTOTHER RES, V24, pS48, DOI 10.1002/ptr.2899
   Khan N, 2007, LIFE SCI, V81, P519, DOI 10.1016/j.lfs.2007.06.011
   Khan N, 2013, CURR PHARM DESIGN, V19, P6141, DOI 10.2174/1381612811319340008
   Kida K, 2000, J AGR FOOD CHEM, V48, P4151, DOI 10.1021/jf000386x
   Kim HS, 2014, REDOX BIOL, V2, P187, DOI 10.1016/j.redox.2013.12.022
   Kim JJY, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/920128
   Kohri T, 2001, J AGR FOOD CHEM, V49, P1042, DOI 10.1021/jf0011236
   Kondo K, 1999, FREE RADICAL BIO MED, V27, P855, DOI 10.1016/S0891-5849(99)00133-1
   Kovacs EMR, 2004, BRIT J NUTR, V91, P431, DOI 10.1079/BJN20041061
   Kristen AV, 2012, CLIN RES CARDIOL, V101, P805, DOI 10.1007/s00392-012-0463-z
   Kucera O, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/476180
   Kuriyama S, 2006, JAMA-J AM MED ASSOC, V296, P1255, DOI 10.1001/jama.296.10.1255
   Kwon DH, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8040082
   Lakka TA, 2007, APPL PHYSIOL NUTR ME, V32, P76, DOI 10.1139/h06-113
   Lambert JD, 2006, DRUG METAB DISPOS, V34, P8, DOI 10.1124/dmd.104.003434
   Lambert JD, 2003, J NUTR, V133, P4172, DOI 10.1093/jn/133.12.4172
   Lambert JD, 2010, ARCH BIOCHEM BIOPHYS, V501, P65, DOI 10.1016/j.abb.2010.06.013
   Lee MJ, 2002, CANCER EPIDEM BIOMAR, V11, P1025
   Legeay S, 2015, NUTRIENTS, V7, P5443, DOI 10.3390/nu7075230
   Liang YM, 2019, PHYTOMEDICINE, V58, DOI 10.1016/j.phymed.2018.11.028
   Lim SCL, 2022, JAMA INTERN MED, V182, P426, DOI 10.1001/jamainternmed.2022.0189
   Lin LC, 2008, CHEM-BIOL INTERACT, V174, P177, DOI 10.1016/j.cbi.2008.05.033
   Liu D, 2016, J NUTR BIOCHEM, V28, P164, DOI 10.1016/j.jnutbio.2015.10.003
   Liu HW, 2015, J AGR FOOD CHEM, V63, P8407, DOI 10.1021/acs.jafc.5b02501
   Lu H, 2003, DRUG METAB DISPOS, V31, P572, DOI 10.1124/dmd.31.5.572
   Lu TM, 2010, FOOD CHEM, V119, P1090, DOI 10.1016/j.foodchem.2009.08.015
   Ma Y, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.640305
   Mahlangu T, 2020, CYTOKINE, V126, DOI 10.1016/j.cyto.2019.154892
   Mangine GT, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-127
   McArthur D, 2014, BMC WOMENS HEALTH, V14, DOI 10.1186/1472-6874-14-49
   McKay DL, 2002, J AM COLL NUTR, V21, P1
   de Oliveira RMM, 2012, CIENCIA TECNOL ALIME, V32, P163, DOI 10.1590/S0101-20612012005000009
   Mielgo-Ayuso J, 2014, BRIT J NUTR, V111, P1263, DOI 10.1017/S0007114513003784
   Mochizuki M, 2002, BBA-GEN SUBJECTS, V1569, P35, DOI 10.1016/S0304-4165(01)00230-6
   Mokgalaboni K, 2021, FOOD FUNCT, V12, P12235, DOI [10.1039/d1fo02696h, 10.1039/D1FO02696H]
   Moon HS, 2007, CHEM-BIOL INTERACT, V167, P85, DOI 10.1016/j.cbi.2007.02.008
   Most J, 2017, EUR J CLIN NUTR, V71, P1040, DOI 10.1038/ejcn.2017.89
   Most J, 2014, INT J OBESITY, V38, P698, DOI 10.1038/ijo.2013.231
   Most J, 2018, ADIPOCYTE, V7, P190, DOI 10.1080/21623945.2018.1469942
   Most J, 2016, AM J CLIN NUTR, V104, P215, DOI 10.3945/ajcn.115.122937
   Mthembu SXH, 2022, LIFE SCI, V297, DOI 10.1016/j.lfs.2022.120467
   MUKHTAR H, 1992, PREV MED, V21, P351, DOI 10.1016/0091-7435(92)90042-G
   Musial C, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21051744
   Muvhulawa N, 2022, PHARMACOL RES, V178, DOI 10.1016/j.phrs.2022.106163
   Nagle DG, 2006, PHYTOCHEMISTRY, V67, P1849, DOI 10.1016/j.phytochem.2006.06.020
   Nakagawa H, 2004, CARCINOGENESIS, V25, P1567, DOI 10.1093/carcin/bgh168
   Nakagawa K, 1997, J NUTR SCI VITAMINOL, V43, P679, DOI 10.3177/jnsv.43.679
   Nakagawa K, 1997, ANAL BIOCHEM, V248, P41, DOI 10.1006/abio.1997.2098
   Nani A, 2021, MOLECULES, V26, DOI 10.3390/molecules26040985
   Naumovski N, 2015, ANTIOXIDANTS-BASEL, V4, P373, DOI 10.3390/antiox4020373
   Ndevahoma F, 2021, EJHAEM, V2, P357, DOI 10.1002/jha2.257
   Negri A, 2018, NUTRIENTS, V10, DOI 10.3390/nu10121936
   Ngcobo SR, 2022, BIOMED PHARMACOTHER, V146, DOI 10.1016/j.biopha.2021.112579
   Nyawo TA, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10111758
   Ohishi Tomokazu, 2016, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, V15, P74, DOI 10.2174/1871523015666160915154443
   Okushio K, 1999, DRUG METAB DISPOS, V27, P309
   Oliviero F, 2013, FRONT PHARMACOL, V4, DOI 10.3389/fphar.2013.00051
   Pandey KB, 2009, OXID MED CELL LONGEV, V2, P270, DOI 10.4161/oxim.2.5.9498
   Pang J, 2016, INT J CARDIOL, V202, P967, DOI 10.1016/j.ijcard.2014.12.176
   Perdices L, 2022, NEURAL REGEN RES, V17, P625, DOI 10.4103/1673-5374.320990
   Pervin M, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20153630
   Peters CM, 2010, FOOD RES INT, V43, P95, DOI 10.1016/j.foodres.2009.08.016
   Raederstorff DG, 2003, J NUTR BIOCHEM, V14, P326, DOI 10.1016/S0955-2863(03)00054-8
   Rasouli H, 2017, INT J FOOD PROP, V20, P1700, DOI 10.1080/10942912.2017.1354017
   Reddy AT, 2020, LIFE SCI, V258, DOI 10.1016/j.lfs.2020.118136
   Ortí JED, 2021, NUTRIENTS, V13, DOI 10.3390/nu13093230
   Scholl C, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0193074
   Sharma A, 2011, FOOD CHEM, V126, P568, DOI 10.1016/j.foodchem.2010.11.044
   Siepen FAD, 2015, CLIN RES CARDIOL, V104, P640, DOI 10.1007/s00392-015-0826-3
   Singh BN, 2011, BIOCHEM PHARMACOL, V82, P1807, DOI 10.1016/j.bcp.2011.07.093
   Singh NA, 2016, NUTR J, V15, DOI 10.1186/s12937-016-0179-4
   Sinha D, 2017, SEMIN CANCER BIOL, V46, P33, DOI 10.1016/j.semcancer.2017.04.001
   Steinmann J, 2013, BRIT J PHARMACOL, V168, P1059, DOI 10.1111/bph.12009
   Stephens RH, 2002, J PHARMACOL EXP THER, V303, P1095, DOI 10.1124/jpet.102.041236
   Stolar M, 2010, AM J MED, V123, pS3, DOI 10.1016/j.amjmed.2009.12.004
   Stuart EC, 2006, LIFE SCI, V79, P2329, DOI 10.1016/j.lfs.2006.07.036
   Suliburska J, 2012, BIOL TRACE ELEM RES, V149, P315, DOI 10.1007/s12011-012-9448-z
   Sun QY, 2013, FRONT BIOSCI-LANDMRK, V18, P332, DOI 10.2741/4104
   Suzuki T, 2016, MOLECULES, V21, DOI 10.3390/molecules21101305
   Takagaki A, 2010, J AGR FOOD CHEM, V58, P1313, DOI 10.1021/jf903375s
   Thielecke F, 2010, EUR J CLIN NUTR, V64, P704, DOI 10.1038/ejcn.2010.47
   Tian B, 2007, ASIA PAC J CLIN NUTR, V16, P153
   Tipoe George L., 2007, Cardiovascular & Hematological Disorders - Drug Targets, V7, P135
   Tosco A, 2017, CELL DEATH DIFFER, V24, P1305, DOI 10.1038/cdd.2016.43
   Tosco A, 2016, CELL DEATH DIFFER, V23, P1380, DOI 10.1038/cdd.2016.22
   Tsuneki Hiroshi, 2004, BMC Pharmacology, V4, P18, DOI 10.1186/1471-2210-4-18
   Ullmann U, 2004, INT J VITAM NUTR RES, V74, P269, DOI 10.1024/0300-9831.74.4.269
   van't Slot G, 2009, J AGR FOOD CHEM, V57, P8041, DOI 10.1021/jf900458e
   Wang CT, 2009, MOL NUTR FOOD RES, V53, P349, DOI 10.1002/mnfr.200800013
   Wang HF, 2000, TRENDS FOOD SCI TECH, V11, P152, DOI 10.1016/S0924-2244(00)00061-3
   Wang JP, 2020, FOOD FUNCT, V11, P534, DOI [10.1039/c9fo02157d, 10.1039/C9FO02157D]
   Wang R, 2004, J AGR FOOD CHEM, V52, P8224, DOI 10.1021/jf048655x
   Wang XH, 2017, CLIN NEUROPHARMACOL, V40, P24, DOI 10.1097/WNF.0000000000000197
   Warden BA, 2001, J NUTR, V131, P1731, DOI 10.1093/jn/131.6.1731
   Westerterp-Plantenga MS, 2005, OBES RES, V13, P1195, DOI 10.1038/oby.2005.142
   Widlansky ME, 2007, J AM COLL NUTR, V26, P95, DOI 10.1080/07315724.2007.10719590
   Wolfram S, 2006, J NUTR, V136, P2512, DOI 10.1093/jn/136.10.2512
   World Health Organization (WHO), 2022, TOP 10 LEAD CAUS DEA
   Wu LY, 2004, EUR J NUTR, V43, P116, DOI 10.1007/s00394-004-0450-x
   Wu XX, 2014, INT IMMUNOPHARMACOL, V23, P434, DOI 10.1016/j.intimp.2014.09.014
   Wu YR, 2017, INT J NANOMED, V12, P7007, DOI 10.2147/IJN.S146296
   Xicota L, 2020, CLIN NUTR, V39, P1292, DOI 10.1016/j.clnu.2019.05.028
   Xicota L, 2017, CURR DRUG TARGETS, V18, P174, DOI 10.2174/1389450116666150825113655
   Yang CS, 1998, CANCER EPIDEM BIOMAR, V7, P351
   Yang CS, 2001, DRUG METAB REV, V33, P237, DOI 10.1081/DMR-120000651
   Yang GY, 1998, CARCINOGENESIS, V19, P611, DOI 10.1093/carcin/19.4.611
   Yang H, 2003, CRIT CARE MED, V31, P1118, DOI 10.1097/01.CCM.0000053523.73064.8A
   Yang YP, 2016, SCI REP-UK, V6, DOI 10.1038/srep29546
   Yin JG, 2016, INT J MOL MED, V37, P398, DOI 10.3892/ijmm.2015.2422
   Younes M, 2018, EFSA J, V16, DOI 10.2903/j.efsa.2018.5239
   Zeng X, 2015, MOL MED REP, V12, P1850, DOI 10.3892/mmr.2015.3603
   Zhang H, 2017, J HUM NUTR DIET, V30, P753, DOI 10.1111/jhn.12470
   Zhang L, 2004, INT J PHARMACEUT, V287, P1, DOI 10.1016/j.ijpharm.2004.08.020
   Zhang L, 2016, GENET MOL RES, V15, DOI 10.4238/gmr.15027874
   Zheng EX, 2016, DRUG SAFETY, V39, P749, DOI 10.1007/s40264-016-0428-7
   Zheng YY, 2010, METABOLISM, V59, P1528, DOI 10.1016/j.metabol.2010.01.018
   Zwolak I, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22084027
NR 196
TC 30
Z9 30
U1 2
U2 45
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD JAN 2
PY 2024
VL 64
IS 1
BP 87
EP 109
DI 10.1080/10408398.2022.2104805
EA JUL 2022
PG 23
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA DS6Q3
UT WOS:000835221400001
PM 35916835
DA 2025-06-11
ER

PT J
AU Pravenec, M
   Kajiya, T
   Zídek, V
   Landa, V
   Mlejnek, P
   Simáková, M
   Silhavy, J
   Malínská, H
   Oliyarnyk, O
   Kazdová, L
   Fan, JL
   Wang, JM
   Kurtz, TW
AF Pravenec, Michal
   Kajiya, Takashi
   Zidek, Vaclav
   Landa, Vladimir
   Mlejnek, Petr
   Simakova, Miroslava
   Silhavy, Jan
   Malinska, Hana
   Oliyarnyk, Olena
   Kazdova, Ludmila
   Fan, Jianglin
   Wang, Jiaming
   Kurtz, Theodore W.
TI Effects of Human C-Reactive Protein on Pathogenesis of Features of the
   Metabolic Syndrome
SO HYPERTENSION
LA English
DT Article
DE C-reactive protein; metabolic syndrome; oxidative stress; transgenic;
   spontaneously hypertensive rat
ID ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; IN-VIVO; MICE;
   ATHEROTHROMBOSIS; ATHEROGENESIS; HYPERTENSION; INFLAMMATION; RATS
AB Major controversy exists as to whether increased C-reactive protein (CRP) contributes to individual components of the metabolic syndrome or is just a secondary response to inflammatory disease processes. We measured blood pressure and metabolic phenotypes in spontaneously hypertensive rats (SHRs) in which we transgenically expressed human CRP in the liver under control of the apolipoprotein E promoter. In transgenic SHRs, serum levels of human CRP approximated the endogenous levels of CRP normally found in the rat. Systolic and diastolic blood pressures measured by telemetry were 10 to 15 mm Hg greater in transgenic SHRs expressing human CRP than in SHR controls (P<0.01). During oral glucose tolerance testing, transgenic SHRs exhibited hyperinsulinemia compared with controls (insulin area under the curve: 36 +/- 7 versus 8 +/- 2 nmol/L per 2 hours, respectively; P<0.05). Transgenic SHRs also exhibited resistance to insulin stimulated glycogenesis in skeletal muscle (174 +/- 18 versus 278 +/- 32 nmol of glucose per gram per 2 hours; P<0.05), hypertriglyceridemia (0.84 +/- 0.05 versus 0.64 +/- 0.03 mmol/L; P<0.05), reduced serum adiponectin (2.4 +/- 0.3 versus 4.3 +/- 0.6 mmol/L; P<0.05), and microalbuminuria (200 +/- 35 versus 26 +/- 5 mg of albumin per gram of creatinine, respectively; P<0.001). Transgenic SHRs had evidence of inflammation and oxidative tissue damage with increased serum levels of interleukin 6 (36.4 +/- 5.2 versus 18 +/- 1.7 pg/mL; P<0.005) and increased hepatic and renal thiobarbituric acid reactive substances (1.2 +/- 0.09 versus 0.8 +/- 0.07 and 1.5 +/- 0.1 versus 1.1 +/- 0.05 nmol/L per milligram of protein, respectively; P<0.01), suggesting that oxidative stress may be mediating adverse effects of increased human CRP. These findings are consistent with the hypothesis that increased CRP is more than just a marker of inflammation and can directly promote multiple features of the metabolic syndrome. (Hypertension. 2011;57:731-737.)
C1 [Pravenec, Michal; Zidek, Vaclav; Landa, Vladimir; Mlejnek, Petr; Simakova, Miroslava; Silhavy, Jan] Acad Sci Czech Republic, Inst Physiol, CR-14220 Prague 4, Czech Republic.
   [Kajiya, Takashi; Wang, Jiaming; Kurtz, Theodore W.] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA.
   [Silhavy, Jan] Czech Univ Life Sci, Fac Agr Food & Nat Resources, Prague, Czech Republic.
   [Malinska, Hana; Oliyarnyk, Olena; Kazdova, Ludmila] Inst Clin & Expt Med, Prague, Czech Republic.
   [Fan, Jianglin] Univ Yamanashi, Dept Mol Pathol, Yamanashi, Japan.
C3 Czech Academy of Sciences; Institute of Physiology of the Czech Academy
   of Sciences; University of California System; University of California
   San Francisco; Czech University of Life Sciences Prague; Institute for
   Clinical & Experimental Medicine (IKEM); University of Yamanashi
RP Pravenec, M (corresponding author), Acad Sci Czech Republic, Inst Physiol, Videnska 1083, CR-14220 Prague 4, Czech Republic.
EM pravenec@biomed.cas.cz
RI Zidek, Vaclav/C-6685-2012; Oliyarnyk, Olena/Q-6380-2019; Silhavy,
   Jan/B-5292-2014; Simakova, Miroslava/R-5367-2019; Landa,
   Vladimir/B-8908-2012; Pravenec, Michal/B-1666-2012; Mlejnek,
   Petr/C-2305-2012
OI Pravenec, Michal/0000-0001-9197-5871; Fan, Jianglin/0000-0002-1737-6130;
   Mlejnek, Petr/0000-0002-4218-8983; Oliyarnyk, Olena/0000-0002-4912-6187;
   Simakova, Miroslava/0000-0003-1468-5832
FU Internal Grant Agency of the Ministry of Health of the Czech Republic
   [NS9757-3]; Ministry of Education of the Czech Republic [ME08006,
   1M0520, MSM6046070901]; Grant Agency of the Czech Republic [301/10/0290,
   P303/10/0505]; Grant Agency of the Academy of Sciences of the Czech
   Republic [IAA500110805]; European Community [HEALTH-F4-2010-241504];
   National Heart, Lung, and Blood Institute of the National Institutes of
   Health; Grants-in-Aid for Scientific Research [22390068] Funding Source:
   KAKEN
FX This work was supported by the Internal Grant Agency of the Ministry of
   Health of the Czech Republic (NS9757-3); the Ministry of Education of
   the Czech Republic (ME08006, 1M0520, and MSM6046070901); the Grant
   Agency of the Czech Republic (301/10/0290 and P303/10/0505); Grant
   Agency of the Academy of Sciences of the Czech Republic (IAA500110805);
   the European Community's Seventh Framework Program (FP7/2007-2013) under
   grant agreement HEALTH-F4-2010-241504 (EURATRANS); and the National
   Heart, Lung, and Blood Institute of the National Institutes of Health.
   M. P. is an international research scholar of the Howard Hughes Medical
   Institute.
CR Contois JH, 2006, CLIN CHIM ACTA, V367, P150, DOI 10.1016/j.cca.2005.12.002
   D'Alessandris C, 2007, DIABETOLOGIA, V50, P840, DOI 10.1007/s00125-006-0522-y
   Danenberg HD, 2008, ATHEROSCLEROSIS, V201, P85, DOI 10.1016/j.atherosclerosis.2008.01.013
   DEBEER FC, 1982, IMMUNOLOGY, V45, P55
   Devaraj S, 2009, ATHEROSCLEROSIS, V203, P67, DOI 10.1016/j.atherosclerosis.2008.05.060
   Devaraj S, 2009, CLIN CHEM, V55, P229, DOI 10.1373/clinchem.2008.108886
   Elliott P, 2009, JAMA-J AM MED ASSOC, V302, P37, DOI 10.1001/jama.2009.954
   Guan HJ, 2009, CLIN CHEM, V55, P274, DOI 10.1373/clinchem.2008.115857
   Haffner SM, 2006, AM J CARDIOL, V97, p3A, DOI 10.1016/j.amjcard.2005.11.010
   Hein TW, 2009, ATHEROSCLEROSIS, V206, P61, DOI 10.1016/j.atherosclerosis.2009.02.002
   Hirschfield GM, 2005, P NATL ACAD SCI USA, V102, P8309, DOI 10.1073/pnas.0503202102
   Jialal I, 2009, CLIN CHEM, V55, P206, DOI 10.1373/clinchem.2008.119206
   Koike T, 2009, CIRCULATION, V120, P2088, DOI 10.1161/CIRCULATIONAHA.109.872796
   Kovacs A, 2007, P NATL ACAD SCI USA, V104, P13768, DOI 10.1073/pnas.0706027104
   Lavie CJ, 2009, AM J MED SCI, V338, P486, DOI 10.1097/MAJ.0b013e3181c61b66
   Malínská H, 2010, MOL CELL BIOCHEM, V335, P119, DOI 10.1007/s11010-009-0248-5
   Ndumele Chiadi E, 2006, J Cardiometab Syndr, V1, P190
   Nordestgaard BG, 2009, NUTR METAB CARDIOVAS, V19, P521, DOI 10.1016/j.numecd.2009.07.005
   Pepys MB, 2006, NATURE, V440, P1217, DOI 10.1038/nature04672
   Reifenberg K, 2005, ARTERIOSCL THROM VAS, V25, P1641, DOI 10.1161/01.ATV.0000171983.95612.90
   Ridker PM, 2009, LANCET, V373, P1175, DOI 10.1016/S0140-6736(09)60447-5
   Scirica BM, 2006, CIRCULATION, V113, P2128, DOI 10.1161/CIRCULATIONAHA.105.611350
   Tennent GA, 2008, ATHEROSCLEROSIS, V196, P248, DOI 10.1016/j.atherosclerosis.2007.05.010
   Teoh H, 2008, ATHEROSCLEROSIS, V201, P318, DOI 10.1016/j.atherosclerosis.2008.02.034
   Torzewski J, 2005, AM J PATHOL, V167, P923, DOI 10.1016/S0002-9440(10)61182-0
   Verma S, 2006, CIRCULATION, V113, P2135
   Verma S, 2002, CIRCULATION, V106, P913, DOI 10.1161/01.CIR.0000029802.88087.5E
   Vongpatanasin W, 2007, CIRCULATION, V115, P1020, DOI 10.1161/CIRCULATIONAHA.106.664854
   Xing DQ, 2008, AM J PATHOL, V172, P22, DOI 10.2353/ajpath.2008.070154
   ZELLER JM, 1992, J LEUKOCYTE BIOL, V52, P449, DOI 10.1002/jlb.52.4.449
   Zhang RX, 2010, HYPERTENSION, V55, P953, DOI 10.1161/HYPERTENSIONAHA.109.140608
NR 31
TC 60
Z9 67
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0194-911X
J9 HYPERTENSION
JI Hypertension
PD APR
PY 2011
VL 57
IS 4
BP 731
EP +
DI 10.1161/HYPERTENSIONAHA.110.164350
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 735RL
UT WOS:000288434600019
PM 21357282
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Zhang, TH
   Tang, XC
   Xu, LH
   Wei, YY
   Hu, YG
   Cui, HR
   Tang, YY
   Chen, T
   Li, CB
   Zhou, LL
   Wang, JJ
AF Zhang, Tian Hong
   Tang, Xiao Chen
   Xu, Li Hua
   Wei, Yan Yan
   Hu, Ye Gang
   Cui, Hui Ru
   Tang, Ying Ying
   Chen, Tao
   Li, Chun Bo
   Zhou, Lin Lin
   Wang, Ji Jun
TI Imbalance Model of Heart Rate Variability and Pulse Wave Velocity in
   Psychotic and Nonpsychotic Disorders
SO SCHIZOPHRENIA BULLETIN
LA English
DT Article
DE psychosis; drug-free; parasympathetic; sympathetic nervous system;
   cardiovascular pathology; autonomic imbalance
ID NERVOUS-SYSTEM DYSFUNCTION; LATE-LIFE DEPRESSION; ARTERIAL STIFFNESS;
   METABOLIC SYNDROME; SCHIZOPHRENIA; RISK; BRAIN; POWER; MORTALITY;
   SYMPTOMS
AB Objectives: Patients with psychiatric disorders have an increased risk of cardiovascular pathologies. A bidirectional feedback model between the brain and heart exists widely in both psychotic and nonpsychotic disorders. The aim of this study was to compare heart rate variability (HRV) and pulse wave velocity (PWV) functions between patients with psychotic and nonpsychotic disorders and to investigate whether subgroups defined by HRV and PWV features improve the transdiagnostic psychopathology of psychiatric classification. Methods: In total, 3448 consecutive patients who visited psychiatric or psychological health services with psychotic (N = 1839) and nonpsychotic disorders (N = 1609) and were drug-free for at least 2 weeks were selected. HRV and PWV indicators were measured via finger photoplethysmography during a 5-minute period of rest. Canonical variates were generated through HRV and PWV indicators by canonical correlation analysis (CCA). Results: All HRV indicators but none of the PWV indicators were significantly reduced in the psychotic group relative to those in the nonpsychotic group. After adjusting for age, gender, and body mass index, many indices of HRV were significantly reduced in the psychotic group compared with those in the nonpsychotic group. CCA analysis revealed 2 subgroups defined by distinct and relatively homogeneous patterns along HRV and PWV dimensions and comprising 19.0% (subgroup 1, n = 655) and 80.9% (subgroup 2, n = 2781) of the sample, each with distinctive features of HRV and PWV functions. Conclusions: HRV functions are significantly impaired among psychiatric patients, especially in those with psychosis. Our results highlight important subgroups of psychiatric patients that have distinct features of HRV and PWV which transcend current diagnostic boundaries.
C1 [Zhang, Tian Hong; Tang, Xiao Chen; Xu, Li Hua; Wei, Yan Yan; Hu, Ye Gang; Cui, Hui Ru; Tang, Ying Ying; Li, Chun Bo; Zhou, Lin Lin; Wang, Ji Jun] Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Sch Med, Shanghai 200030, Peoples R China.
   [Chen, Tao] Univ Waterloo, Big Data Res Lab, Waterloo, ON, Canada.
   [Chen, Tao] Harvard Univ, Labor & Worklife Program, Boston, MA 02115 USA.
   [Chen, Tao] Niacin Shanghai Technol Co Ltd, Shanghai, Peoples R China.
   [Wang, Ji Jun] Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai, Peoples R China.
   [Wang, Ji Jun] Shanghai Jiao Tong Univ, Inst Psychol & Behav Sci, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University; University of Waterloo; Harvard
   University; Chinese Academy of Sciences; Center for Excellence in Brain
   Science and Intelligence Technology, CAS; Shanghai Jiao Tong University
RP Wang, JJ (corresponding author), Shanghai Jiao Tong Univ, Sch Med,Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders 13dz2260500,Mi, BioX Inst,Key Lab Genet Dev & Neuropsychiat Disor, 600 Wanping Nan Rd, Shanghai 200030, Peoples R China.
EM jijunwang27@163.com
RI 周, 林/KIH-4929-2024; Wang, Jijun/HTP-0666-2023; Zhang,
   TianHong/IQS-6148-2023; Chen, Jianhua/AAS-8417-2020; Xu,
   Lihua/P-8054-2019
OI hu, yegang/0000-0002-9863-2836
FU Ministry of Science and Technology of China; National Key R&D Program of
   China [2016YFC1306800]; National Natural Science Foundation of China
   [81671329, 81671332]; Science and Technology Commission of Shanghai
   Municipality [19441907800, 17411953100, 19ZR1445200, 19411950800];
   Construction, Shanghai 3-Year Public Health Action Plan [GWV-10.1-XK18];
   Shanghai Clinical Research Center for Mental Health [19MC1911100];
   Clinical Research Center at Shanghai Mental Health Center [CRC2018ZD01,
   CRC2018ZD04, CRC2018YB01, CRC2019ZD02]
FX This study was supported by the Ministry of Science and Technology of
   China, National Key R&D Program of China (2016YFC1306800), National
   Natural Science Foundation of China (81671329 and 81671332), Science and
   Technology Commission of Shanghai Municipality (19441907800,
   17411953100, 19ZR1445200, and 19411950800), Construction, Shanghai
   3-Year Public Health Action Plan (GWV-10.1-XK18), Shanghai Clinical
   Research Center for Mental Health (19MC1911100), and the Clinical
   Research Center at Shanghai Mental Health Center (CRC2018ZD01,
   CRC2018ZD04, CRC2018YB01, and CRC2019ZD02).
CR AKSELROD S, 1981, SCIENCE, V213, P220, DOI 10.1126/science.6166045
   Al E, 2020, P NATL ACAD SCI USA, V117, P10575, DOI 10.1073/pnas.1915629117
   Alvares GA, 2016, J PSYCHIATR NEUROSCI, V41, P89, DOI 10.1503/jpn.140217
   [Anonymous], 2004, J CLIN PSYCHIAT, V65, P267
   Bassett D, 2016, AUST NZ J PSYCHIAT, V50, P511, DOI 10.1177/0004867415622689
   BERNTSON GG, 1990, PSYCHOPHYSIOLOGY, V27, P586, DOI 10.1111/j.1469-8986.1990.tb01982.x
   BIGGER JT, 1988, AM J CARDIOL, V61, P208, DOI 10.1016/0002-9149(88)90917-4
   Brown L, 2018, J AFFECT DISORDERS, V235, P456, DOI 10.1016/j.jad.2018.04.071
   Camm AJ, 1996, CIRCULATION, V93, P1043
   Carney Robert M, 2009, Cleve Clin J Med, V76 Suppl 2, pS13, DOI 10.3949/ccjm.76.s2.03
   Celik A, 2011, CLIN INVEST MED, V34, pE349
   Clamor A, 2016, BRIT J PSYCHIAT, V208, P9, DOI 10.1192/bjp.bp.114.160762
   Druss BG, 2001, ARCH GEN PSYCHIAT, V58, P565, DOI 10.1001/archpsyc.58.6.565
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   Findikli E, 2016, CLIN PSYCHOPHARM NEU, V14, P365, DOI 10.9758/cpn.2016.14.4.365
   First MB, 2016, LANCET PSYCHIAT, V3, P579, DOI 10.1016/S2215-0366(16)00048-1
   Fraley MA, 2005, OBES REV, V6, P275, DOI 10.1111/j.1467-789X.2005.00199.x
   Frasure-Smith N, 2009, BRAIN BEHAV IMMUN, V23, P1140, DOI 10.1016/j.bbi.2009.07.005
   Goff DC, 2005, SCHIZOPHR RES, V80, P45, DOI 10.1016/j.schres.2005.08.010
   Goldstein DS, 2011, EXP PHYSIOL, V96, P1255, DOI 10.1113/expphysiol.2010.056259
   Heiberg IH, 2019, ACTA PSYCHIAT SCAND, V139, P558, DOI 10.1111/acps.13017
   Jandackova VK, 2016, PSYCHOL MED, V46, P2121, DOI 10.1017/S003329171600060X
   Jung W, 2019, CLIN PSYCHOPHARM NEU, V17, P459, DOI 10.9758/cpn.2019.17.4.459
   Kleiger RE, 2005, ANN NONINVAS ELECTRO, V10, P88, DOI 10.1111/j.1542-474X.2005.10101.x
   Koch C, 2019, PSYCHOL MED, V49, P1948, DOI 10.1017/S0033291719001351
   Kop WJ, 2010, PSYCHOSOM MED, V72, P626, DOI 10.1097/PSY.0b013e3181eadd2b
   Laurent S, 2006, EUR HEART J, V27, P2588, DOI 10.1093/eurheartj/ehl254
   Laursen TM, 2011, SCHIZOPHR RES, V131, P101, DOI 10.1016/j.schres.2011.06.008
   Lemogne C, 2021, CURR CARDIOL REP, V23, DOI 10.1007/s11886-020-01436-5
   Lizano P, 2021, MOL PSYCHIATR, V26, P3430, DOI 10.1038/s41380-020-00914-0
   Lombardi F, 2001, CARDIOVASC RES, V50, P210, DOI 10.1016/S0008-6363(01)00221-8
   McCraty Rollin, 2015, Glob Adv Health Med, V4, P46, DOI 10.7453/gahmj.2014.073
   McEvoy JP, 2005, SCHIZOPHR RES, V80, P19, DOI 10.1016/j.schres.2005.07.014
   Montalvo-Ortiz JL, 2016, AM J MED GENET B, V171, P81, DOI 10.1002/ajmg.b.32395
   Newcomer JW, 2007, JAMA-J AM MED ASSOC, V298, P1794, DOI 10.1001/jama.298.15.1794
   Nürnberger J, 2002, J HYPERTENS, V20, P2407, DOI 10.1097/00004872-200212000-00020
   Olive LS, 2020, GEN HOSP PSYCHIAT, V62, P6, DOI 10.1016/j.genhosppsych.2019.10.001
   PAGANI M, 1986, CIRC RES, V59, P178, DOI 10.1161/01.RES.59.2.178
   Palta P, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.118.011045
   Philip AB, 2021, INT J PSYCHIAT CLIN, V25, P103, DOI 10.1080/13651501.2020.1787454
   Phillips AA, 2014, PSYCHIAT RES, V215, P14, DOI 10.1016/j.psychres.2013.10.020
   Pincus Harold Alan, 2004, World Psychiatry, V3, P18
   Scuteri A, 2014, J ALZHEIMERS DIS, V42, pS401, DOI 10.3233/JAD-141416
   Sgoifo A, 2015, STRESS, V18, P343, DOI 10.3109/10253890.2015.1045868
   Singer J, 2014, AGEING RES REV, V15, P16, DOI 10.1016/j.arr.2014.02.002
   Smucny J, 2018, NEUROPSYCHOPHARMACOL, V43, P598, DOI 10.1038/npp.2017.233
   Stein PK, 2012, SLEEP MED REV, V16, P47, DOI 10.1016/j.smrv.2011.02.005
   Sullivan Gail M, 2012, J Grad Med Educ, V4, P279, DOI 10.4300/JGME-D-12-00156.1
   Thayer JF, 2000, J AFFECT DISORDERS, V61, P201, DOI 10.1016/S0165-0327(00)00338-4
   Tiemeier H, 2003, J AM GERIATR SOC, V51, P1105, DOI 10.1046/j.1532-5415.2003.51359.x
   Tobaldini E, 2020, NEUROSCI BIOBEHAV R, V116, P154, DOI 10.1016/j.neubiorev.2020.06.029
   Van Dam NT, 2017, BIOL PSYCHIAT, V81, P484, DOI 10.1016/j.biopsych.2016.06.027
   van Sloten TT, 2016, J PSYCHIATR NEUROSCI, V41, P162, DOI 10.1503/jpn.140334
   von Wowern E, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0135659
   Watson D, 2017, J AFFECT DISORDERS, V216, P58, DOI 10.1016/j.jad.2016.09.065
   Wilkinson IB, 2001, HYPERTENSION, V38, P1461, DOI 10.1161/hy1201.097723
NR 56
TC 9
Z9 9
U1 1
U2 16
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0586-7614
EI 1745-1701
J9 SCHIZOPHRENIA BULL
JI Schizophr. Bull.
PD JAN
PY 2022
VL 48
IS 1
BP 154
EP 165
DI 10.1093/schbul/sbab080
EA JUL 2021
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA YL9FY
UT WOS:000746192700019
PM 34313787
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Sokumbi, O
   Hodge, DO
   Ederaine, SA
   Alavi, A
   Alikhan, A
AF Sokumbi, Olayemi
   Hodge, David O.
   Ederaine, Sophia A.
   Alavi, Afsaneh
   Alikhan, Ali
TI Comorbid diseases of Hidradenitis Suppurativa: a 15-Year
   Population-Based study in Olmsted County, Minnesota, USA
SO INTERNATIONAL JOURNAL OF DERMATOLOGY
LA English
DT Article
ID MEDICAL-RECORDS-LINKAGE; POLYCYSTIC-OVARY-SYNDROME; METABOLIC SYNDROME;
   PREVALENCE; HEALTH; SEVERITY; HISTORY; ADULTS; RISK
AB Background Like other chronic, inflammatory skin disorders, hidradenitis suppurativa (HS) is increasingly recognized to be associated with various medical disorders. Objective Using the Rochester Epidemiology Project (REP), we sought to conduct the first American population-based study examining the association between HS and various comorbid conditions. Methods From the REP database, we identified patients diagnosed with HS from 2003 through 2018 who were residents of Olmsted County, Minnesota, USA, along with age- and gender-matched controls. The frequency of a wide variety of comorbid conditions was compared between the groups. Results A total of 1160 patients with HS were identified during the study period. Compared with age- and gender-matched controls, patients with HS had a significantly higher frequency of several medical conditions, including depression, anxiety, hyperlipidemia, acne conglobata, dissecting cellulitis, pilonidal cysts, polycystic ovary syndrome, diabetes, chronic kidney disease, psoriasis, atopic dermatitis, obesity, and disordered substance use, among others. Limitations Our study was limited by its retrospective design. Conclusions Providers caring for patients with HS should consider these results, along with those of similar studies, and obtain a thorough history, comprehensive physical examination, and, potentially, laboratory testing and referral to other specialists.
C1 [Sokumbi, Olayemi] Mayo Clin, Dept Dermatol & Lab Med, 4500 San Pablo Rd, Jacksonville, FL 32224 USA.
   [Hodge, David O.] Mayo Clin, Div Biomed Stat, Dept Quantitat Hlth Sci, Jacksonville, FL 32224 USA.
   [Ederaine, Sophia A.] Mayo Clin, Alix Sch Med, Arizona Campus, Scottsdale, AZ USA.
   [Alavi, Afsaneh] Mayo Clin, Dept Dermatol, Rochester, MN USA.
   [Alikhan, Ali] Sutter Med Fdn, Dept Dermatol, Sacramento, CA USA.
C3 Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic Phoenix; Mayo Clinic
RP Sokumbi, O (corresponding author), Mayo Clin, Dept Dermatol & Lab Med, 4500 San Pablo Rd, Jacksonville, FL 32224 USA.
EM sokumbi.olayemi@mayo.edu
FU National Institute on Aging of the National Institutes of Health
   [R01AG034676]
FX This study was made possible using the resources of the Rochester
   Epidemiology Project, which is supported by the National Institute on
   Aging of the National Institutes of Health under Award Number
   R01AG034676. The content is solely the responsibility of the authors and
   does not necessarily represent the official views of the National
   Institutes of Health.
CR Acharya P, 2020, J AM ACAD DERMATOL, V82, P1006, DOI 10.1016/j.jaad.2019.10.044
   Alavi A, 2015, AM J CLIN DERMATOL, V16, P61, DOI 10.1007/s40257-014-0105-5
   Aldana Paola C, 2019, Int J Womens Dermatol, V5, P335, DOI 10.1016/j.ijwd.2019.09.007
   Alikhan A, 2009, J AM ACAD DERMATOL, V60, P539, DOI 10.1016/j.jaad.2008.11.911
   Bailey AMJ, 2021, J AM ACAD DERMATOL, V84, P844, DOI 10.1016/j.jaad.2020.10.005
   Canoui-Poitrine F, 2009, J AM ACAD DERMATOL, V61, P51, DOI 10.1016/j.jaad.2009.02.013
   Cartron Alexander, 2019, Int J Womens Dermatol, V5, P330, DOI 10.1016/j.ijwd.2019.06.026
   Chen WT, 2019, JAMA DERMATOL, V155, P1022, DOI 10.1001/jamadermatol.2019.0891
   Diamanti-Kandarakis E, 1999, J CLIN ENDOCR METAB, V84, P4006, DOI 10.1210/jc.84.11.4006
   Egeberg A, 2016, JAMA DERMATOL, V152, P429, DOI 10.1001/jamadermatol.2015.6264
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Gallagher Catriona, 2017, JAAD Case Rep, V3, P436, DOI 10.1016/j.jdcr.2017.06.008
   Garg A, 2018, BRIT J DERMATOL, V178, P709, DOI 10.1111/bjd.15939
   Garg A, 2018, J AM ACAD DERMATOL, V79, P495, DOI 10.1016/j.jaad.2018.02.053
   Garg A, 2018, J INVEST DERMATOL, V138, P1288, DOI 10.1016/j.jid.2018.01.009
   Golbari Nicole Mona, 2018, JAAD Case Rep, V4, P278, DOI 10.1016/j.jdcr.2017.11.024
   Goldburg SR, 2020, J AM ACAD DERMATOL, V82, P1045, DOI 10.1016/j.jaad.2019.08.090
   González-López MA, 2017, CLIN EXP DERMATOL, V42, P642, DOI 10.1111/ced.13153
   González-López MA, 2016, DERMATOLOGY, V232, P162, DOI 10.1159/000439562
   Hughes R, 2017, BRIT J DERMATOL, V176, P1404, DOI 10.1111/bjd.15365
   Jalenques I, 2020, J AM ACAD DERMATOL, V83, P542, DOI 10.1016/j.jaad.2020.03.041
   Jemec GBE, 1996, J AM ACAD DERMATOL, V35, P191, DOI 10.1016/S0190-9622(96)90321-7
   Kimball AB, 2018, DERMATOLOGY THER, V8, P557, DOI 10.1007/s13555-018-0264-z
   Kirby JS, 2014, JAMA DERMATOL, V150, P937, DOI 10.1001/jamadermatol.2014.691
   Kohorst JJ, 2015, J AM ACAD DERMATOL, V73, pS27, DOI 10.1016/j.jaad.2015.07.055
   Kraft JN, 2007, J CUTAN MED SURG, V11, P125, DOI 10.2310/7750.2007.00019
   Kromann CB, 2014, ACTA DERM-VENEREOL, V94, P553, DOI 10.2340/00015555-1800
   Lee JH, 2018, J EUR ACAD DERMATOL, V32, P1784, DOI 10.1111/jdv.15071
   Lesort C, 2019, BRIT J DERMATOL, V181, P839, DOI 10.1111/bjd.17930
   Lim ZV, 2016, ANN DERMATOL, V28, P147, DOI 10.5021/ad.2016.28.2.147
   Lloyd-McLennan AM, 2021, PEDIATR DERMATOL, V38, P98, DOI 10.1111/pde.14417
   March WA, 2010, HUM REPROD, V25, P544, DOI 10.1093/humrep/dep399
   Mebazaa A, 2009, ACTA DERMATOVEN ALP, V18, P165
   Melton LJ, 1996, MAYO CLIN PROC, V71, P266, DOI 10.4065/71.3.266
   Miller IM, 2018, CLIN EXP DERMATOL, V43, P899, DOI 10.1111/ced.13606
   Miller IM, 2016, ACTA DERM-VENEREOL, V96, P68, DOI 10.2340/00015555-2072
   Miller IM, 2014, JAMA DERMATOL, V150, P1273, DOI 10.1001/jamadermatol.2014.1165
   Özkur E, 2021, CLIN EXP DERMATOL, V46, P532, DOI 10.1111/ced.14478
   Patel KR, 2020, J AM ACAD DERMATOL, V83, P737, DOI 10.1016/j.jaad.2019.11.068
   Phan K, 2019, CLIN EXP DERMATOL, V44, pE126, DOI 10.1111/ced.13922
   Phan K, 2020, ANN TRANSL MED, V8, DOI 10.21037/atm-20-1028
   Phan K, 2020, INT J DERMATOL, V59, P221, DOI 10.1111/ijd.14697
   Porter ML, 2017, SEMIN CUTAN MED SURG, V36, P55, DOI 10.12788/j.sder.2017.018
   Reddy S, 2019, JAMA DERMATOL, V155, P797, DOI 10.1001/jamadermatol.2019.0164
   Richette P, 2014, J RHEUMATOL, V41, P490, DOI 10.3899/jrheum.130977
   Rocca WA, 2012, MAYO CLIN PROC, V87, P1202, DOI 10.1016/j.mayocp.2012.08.012
   Rodríguez-Zuñiga MJM, 2019, ACTAS DERMO-SIFILOGR, V110, P279, DOI 10.1016/j.ad.2018.10.020
   Sabat R, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031810
   Shahi V, 2014, DERMATOLOGY, V229, P154, DOI 10.1159/000363381
   Shalom G, 2015, BRIT J DERMATOL, V173, P464, DOI 10.1111/bjd.13777
   Sherman S, 2021, J AM ACAD DERMATOL, V85, P1473, DOI 10.1016/j.jaad.2020.12.051
   Shlyankevich J, 2014, J AM ACAD DERMATOL, V71, P1144, DOI 10.1016/j.jaad.2014.09.012
   St Sauver JL, 2012, INT J EPIDEMIOL, V41, P1614, DOI 10.1093/ije/dys195
   St Sauver JL, 2012, MAYO CLIN PROC, V87, P151, DOI 10.1016/j.mayocp.2011.11.009
   St Sauver JL, 2011, AM J EPIDEMIOL, V173, P1059, DOI 10.1093/aje/kwq482
   Thomas CL, 2014, CLIN EXP DERMATOL, V39, P315, DOI 10.1111/ced.12269
   Tzellos T, 2015, BRIT J DERMATOL, V173, DOI 10.1111/bjd.14024
   United States Census Bureau, 2019, QUICK FACTS OLMST CO, V2021
   Vazquez BG, 2013, J INVEST DERMATOL, V133, P97, DOI 10.1038/jid.2012.255
   Wright S, 2020, J AM ACAD DERMATOL, V83, P1360, DOI 10.1016/j.jaad.2020.05.090
   Zouboulis CC, 2015, DERMATOLOGY, V231, P184, DOI 10.1159/000431175
NR 61
TC 7
Z9 8
U1 2
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0011-9059
EI 1365-4632
J9 INT J DERMATOL
JI Int. J. Dermatol.
PD NOV
PY 2022
VL 61
IS 11
BP 1372
EP 1379
DI 10.1111/ijd.16228
EA APR 2022
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 5J0QO
UT WOS:000788656500001
PM 35485975
DA 2025-06-11
ER

PT J
AU Gabrielsen, JS
   Gao, Y
   Simcox, JA
   Huang, JY
   Thorup, D
   Jones, D
   Cooksey, RC
   Gabrielsen, D
   Adams, TD
   Hunt, SC
   Hopkins, PN
   Cefalu, WT
   McClain, DA
AF Gabrielsen, J. Scott
   Gao, Yan
   Simcox, Judith A.
   Huang, Jingyu
   Thorup, David
   Jones, Deborah
   Cooksey, Robert C.
   Gabrielsen, David
   Adams, Ted D.
   Hunt, Steven C.
   Hopkins, Paul N.
   Cefalu, William T.
   McClain, Donald A.
TI Adipocyte iron regulates adiponectin and insulin sensitivity
SO JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
ID SERUM FERRITIN CONCENTRATION; TRANSCRIPTION FACTOR FOXO1; BETA-CELL
   FUNCTION; HEREDITARY HEMOCHROMATOSIS; METABOLIC SYNDROME;
   DIABETES-MELLITUS; OXIDATIVE STRESS; MOUSE MODEL;
   SACCHAROMYCES-CEREVISIAE; TRANSFERRIN RECEPTORS
AB Iron overload is associated with increased diabetes risk. We therefore investigated the effect of iron on adiponectin, an insulin-sensitizing adipokine that is decreased in diabetic patients. In humans, normal-range serum ferritin levels were inversely associated with adiponectin, independent of inflammation. Ferritin was increased and adiponectin was decreased in type 2 diabetic and in obese diabetic subjects compared with those in equally obese individuals without metabolic syndrome. Mice fed a high-iron diet and cultured adipocytes treated with iron exhibited decreased adiponectin mRNA and protein. We found that iron negatively regulated adiponectin transcription via FOXO1-mediated repression. Further, loss of the adipocyte iron export channel, ferroportin, in mice resulted in adipocyte iron loading, decreased adiponectin, and insulin resistance. Conversely, organismal iron overload and increased adipocyte ferroportin expression because of hemochromatosis are associated with decreased adipocyte iron, increased adiponectin, improved glucose tolerance, and increased insulin sensitivity. Phlebotomy of humans with impaired glucose tolerance and ferritin values in the highest quartile of normal increased adiponectin and improved glucose tolerance. These findings demonstrate a causal role for iron as a risk factor for metabolic syndrome and a role for adipocytes in modulating metabolism through adiponectin in response to iron stores.
C1 [Adams, Ted D.; Hunt, Steven C.; Hopkins, Paul N.] Univ Utah, Sch Med, Dept Med, Div Cardiovasc Genet, Salt Lake City, UT USA.
   [Gabrielsen, J. Scott; Gao, Yan; Simcox, Judith A.; Huang, Jingyu; Thorup, David; Jones, Deborah; Cooksey, Robert C.; Gabrielsen, David; McClain, Donald A.] Univ Utah, Sch Med, Dept Biochem, Salt Lake City, UT USA.
   [Cooksey, Robert C.; McClain, Donald A.] VA Med Ctr, Res Serv, Salt Lake City, UT USA.
   [Cefalu, William T.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA USA.
C3 Utah System of Higher Education; University of Utah; Utah System of
   Higher Education; University of Utah; Louisiana State University System;
   Louisiana State University; Pennington Biomedical Research Center
RP McClain, DA (corresponding author), Div Endocrinol, 30 North,2030 East, Salt Lake City, UT 84132 USA.
EM donald.mcclain@hsc.utah.edu
RI Hsia, Daniel/AAJ-6247-2020; Gabrielsen, Joseph/HJY-5745-2023
OI Simcox, Judith/0000-0001-7350-6342; McClain, Don/0000-0002-3310-2359
FU Research Service of the Veterans Administration; NIH [DK59512,
   5-T32-DK-007115]; University of Utah Clinical and Translational Science
   Award; National Center for Advancing Translational Sciences
   [UL1RR025764]
FX This work was supported by the Research Service of the Veterans
   Administration and NIH grants DK59512 and 5-T32-DK-007115 and the
   University of Utah Clinical and Translational Science Award funded by
   the National Center for Advancing Translational Sciences (UL1RR025764).
   We would like to thank Tom Greene (UL1 RR025764) for help with the
   statistical analysis of our data and also to acknowledge the assistance
   of the Clinical Services, Technology, and Biostatistics and Study Design
   Cores of the CTSA. Mice used in the study were supplied by Nancy Andrews
   (Duke University) and Phillip Scherer (University of Texas
   Southwestern).
CR Abboud S, 2000, J BIOL CHEM, V275, P19906, DOI 10.1074/jbc.M000713200
   Abraham D, 2006, DIABETOLOGIA, V49, P2546, DOI 10.1007/s00125-006-0445-7
   Adams TD, 2010, OBESITY, V18, P121, DOI 10.1038/oby.2009.178
   Afkhami-Ardekani M, 2009, J DIABETES COMPLICAT, V23, P194, DOI 10.1016/j.jdiacomp.2007.11.006
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Arita Y, 1999, BIOCHEM BIOPH RES CO, V257, P79, DOI 10.1006/bbrc.1999.0255
   Bekri S, 2006, GASTROENTEROLOGY, V131, P788, DOI 10.1053/j.gastro.2006.07.007
   Bergman RN, 2002, EUR J CLIN INVEST, V32, P35, DOI 10.1046/j.1365-2362.32.s3.5.x
   BOFILL C, 1994, METABOLISM, V43, P614, DOI 10.1016/0026-0495(94)90204-6
   Boston Ray C, 2003, Diabetes Technol Ther, V5, P1003, DOI 10.1089/152091503322641060
   BRINK B, 1976, J LAB CLIN MED, V88, P725
   Cairo G, 1997, BLOOD, V89, P2546, DOI 10.1182/blood.V89.7.2546
   CASEY JL, 1988, SCIENCE, V240, P924, DOI 10.1126/science.2452485
   Chakrabarti P, 2009, J BIOL CHEM, V284, P13296, DOI 10.1074/jbc.C800241200
   Chen Z, 2005, CELL METAB, V1, P93, DOI 10.1016/j.cmet.2004.12.009
   Cheng K, 2010, J CLIN INVEST, V120, P2171, DOI 10.1172/JCI35846
   COOK JD, 1974, AM J CLIN NUTR, V27, P681, DOI 10.1093/ajcn/27.7.681
   Cooksey RC, 2004, ENDOCRINOLOGY, V145, P5305, DOI 10.1210/en.2004-0392
   Cooksey RC, 2010, AM J PHYSIOL-ENDOC M, V298, pE1236, DOI 10.1152/ajpendo.00022.2010
   DAVIS RJ, 1986, J BIOL CHEM, V261, P8708
   De Domenico I, 2008, NAT REV MOL CELL BIO, V9, P72, DOI 10.1038/nrm2295
   Donovan A, 2000, NATURE, V403, P776, DOI 10.1038/35001596
   Donovan A, 2005, CELL METAB, V1, P191, DOI 10.1016/j.cmet.2005.01.003
   Facchini FS, 2002, GASTROENTEROLOGY, V122, P931, DOI 10.1053/gast.2002.32403
   Fan WQ, 2009, J BIOL CHEM, V284, P12188, DOI 10.1074/jbc.M808915200
   Farahani P, 2004, OBES RES, V12, P191, DOI 10.1038/oby.2004.26
   Fargnoli JL, 2008, AM J CLIN NUTR, V88, P1213, DOI 10.3945/ajcn.2008.26480
   Fernández-Real JM, 2002, DIABETES CARE, V25, P2249, DOI 10.2337/diacare.25.12.2249
   Fernández-Real JM, 2005, CLIN CHEM, V51, P1201, DOI 10.1373/clinchem.2004.046847
   Fernández-Real JM, 2002, DIABETES, V51, P1000, DOI 10.2337/diabetes.51.4.1000
   Fernández-Real JM, 2002, DIABETES, V51, P2348, DOI 10.2337/diabetes.51.8.2348
   Festa M, 2000, J BIOL CHEM, V275, P36708, DOI 10.1074/jbc.M004988200
   Fleming DJ, 2001, AM J CLIN NUTR, V73, P638
   Ford ES, 1999, DIABETES CARE, V22, P1978, DOI 10.2337/diacare.22.12.1978
   Forouhi NG, 2007, DIABETOLOGIA, V50, P949, DOI 10.1007/s00125-007-0604-5
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gabay C, 1999, NEW ENGL J MED, V340, P448, DOI 10.1056/NEJM199902113400607
   Gillum RF, 2001, INT J OBESITY, V25, P639, DOI 10.1038/sj.ijo.0801561
   Green A, 2006, METABOLISM, V55, P1042, DOI 10.1016/j.metabol.2006.03.015
   Gross DN, 2008, ONCOGENE, V27, P2320, DOI 10.1038/onc.2008.25
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Hatunic M, 2010, METABOLISM, V59, P380, DOI 10.1016/j.metabol.2009.08.006
   Haurie V, 2003, J BIOL CHEM, V278, P45391, DOI 10.1074/jbc.M307447200
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Huang JH, 2007, J BIOL CHEM, V282, P37501, DOI 10.1074/jbc.M703625200
   Huang JY, 2011, DIABETES, V60, P80, DOI 10.2337/db10-0593
   Iwasaki T, 2005, DIABETES CARE, V28, P2486, DOI 10.2337/diacare.28.10.2486
   Jehn M, 2004, DIABETES CARE, V27, P2422, DOI 10.2337/diacare.27.10.2422
   Jiang R, 2004, JAMA-J AM MED ASSOC, V291, P711, DOI 10.1001/jama.291.6.711
   Joitihan HA, 2008, MOL MED, V14, P98, DOI 10.2119/2007-00114.Jouihan
   Ku BJ, 2009, DIS MARKERS, V27, P303, DOI [10.1155/2009/931082, 10.3233/DMA-2009-0676]
   Kubota N, 2002, J BIOL CHEM, V277, P25863, DOI 10.1074/jbc.C200251200
   Lee P, 2005, P NATL ACAD SCI USA, V102, P1906, DOI 10.1073/pnas.0409808102
   Liu ML, 2010, BIOCHEM J, V425, P41, DOI 10.1042/BJ20091045
   Mangiagli A, 1998, J PEDIATR ENDOCR MET, V11, P985
   McClain DA, 2006, DIABETOLOGIA, V49, P1661, DOI 10.1007/s00125-006-0200-0
   McClung JP, 2009, NUTR REV, V67, P100, DOI 10.1111/j.1753-4887.2008.00145.x
   Mojiminiyi OA, 2008, NUTR METAB CARDIOVAS, V18, P559, DOI 10.1016/j.numecd.2007.07.007
   Nakae J, 2003, DEV CELL, V4, P119, DOI 10.1016/S1534-5807(02)00401-X
   Nakae J, 2008, DIABETES, V57, P563, DOI 10.2337/db07-0698
   Nawrocki AR, 2006, J BIOL CHEM, V281, P2654, DOI 10.1074/jbc.M505311200
   NELSON R, 1978, SOUTHERN MED J, V71, P1482, DOI 10.1097/00007611-197812000-00011
   Nemeth E, 2004, SCIENCE, V306, P2090, DOI 10.1126/science.1104742
   Qi L, 2007, DIABETES CARE, V30, P101, DOI 10.2337/dc06-1686
   Qiang L, 2010, J BIOL CHEM, V285, P27396, DOI 10.1074/jbc.M110.140228
   Qiao LP, 2006, J BIOL CHEM, V281, P39915, DOI 10.1074/jbc.M607215200
   ROSS CE, 1975, AM J CLIN PATHOL, V63, P179
   Rumberger JM, 2004, DIABETES, V53, P2535, DOI 10.2337/diabetes.53.10.2535
   Saad MF, 1997, DIABETES, V46, P2044, DOI 10.2337/diabetes.46.12.2044
   Semenza GL, 2009, BLOOD, V114, P2015, DOI 10.1182/blood-2009-05-189985
   Seo JB, 2004, J BIOL CHEM, V279, P22108, DOI 10.1074/jbc.M400238200
   Shakoury-Elizeh M, 2010, J BIOL CHEM, V285, P14823, DOI 10.1074/jbc.M109.091710
   Sharifi F, 2008, DIABETES VASC DIS RE, V5, P15, DOI 10.3132/dvdr.2008.003
   Stull AJ, 2010, METABOLISM, V59, P1358, DOI 10.1016/j.metabol.2009.12.020
   Subauste AR, 2007, AM J PHYSIOL-ENDOC M, V293, pE159, DOI 10.1152/ajpendo.00629.2006
   Szmuilowicz ED, 2009, NAT REV ENDOCRINOL, V5, P553, DOI 10.1038/nrendo.2009.166
   TANNER LI, 1987, J BIOL CHEM, V262, P8975
   van der Heide LP, 2005, TRENDS BIOCHEM SCI, V30, P81, DOI 10.1016/j.tibs.2004.12.002
   WALTERS GO, 1973, J CLIN PATHOL, V26, P770, DOI 10.1136/jcp.26.10.770
   Weyer C, 2001, J CLIN ENDOCR METAB, V86, P1930, DOI 10.1210/jc.86.5.1930
   Yamagishi H, 2000, J NUTR BIOCHEM, V11, P455, DOI 10.1016/S0955-2863(00)00113-3
   Yamauchi T, 2001, NAT MED, V7, P941, DOI 10.1038/90984
   Zhou XY, 1998, P NATL ACAD SCI USA, V95, P2492, DOI 10.1073/pnas.95.5.2492
NR 83
TC 242
Z9 262
U1 0
U2 32
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA
SN 0021-9738
EI 1558-8238
J9 J CLIN INVEST
JI J. Clin. Invest.
PD OCT
PY 2012
VL 122
IS 10
BP 3529
EP 3540
DI 10.1172/JCI44421
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 013VK
UT WOS:000309333800024
PM 22996660
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Andersen, CJ
   Fernandez, ML
AF Andersen, Catherine J.
   Fernandez, Maria Luz
TI Dietary strategies to reduce metabolic syndrome
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Article
DE Metabolic syndrome; Dyslipidemia; Insulin resistance; Inflammation;
   Energy restriction; Carbohydrate-restricted diets; Fatty acids;
   Functional foods; Mediterranean diet
ID HIGH-FAT DIET; CARDIOVASCULAR RISK PROFILE; DAIRY PRODUCT CONSUMPTION;
   LOW-DENSITY-LIPOPROTEIN; INSULIN-RESISTANT MEN; WEIGHT-LOSS;
   MEDITERRANEAN DIET; ALCOHOL-CONSUMPTION; ADIPOSE-TISSUE; CARBOHYDRATE
   RESTRICTION
AB Metabolic syndrome (MetS) is a cluster of metabolic abnormalities characterized by central obesity, dyslipidemias, hypertension, high fasting glucose, chronic low-grade inflammation and oxidative stress. This condition has become an increasing problem in our society where about 34 % of adults are diagnosed with MetS. In parallel with the adult situation, a significant number of children present lipid abnormalities and insulin resistance, which can be used as markers of MetS in the pediatric population. Changes in lifestyle including healthy dietary regimens and increased physical activity should be the first lines of therapy to decrease MetS. In this article, we present the most recent information on successful dietary modifications that can reduce the parameters associated with MetS. Successful dietary strategies include energy restriction and weight loss, manipulation of dietary macronutrients-either through restriction of carbohydrates, fat, or enrichment in beneficial fatty acids, incorporation of functional foods and bioactive nutrients, and adherence to dietary and lifestyle patterns such the Mediterranean diet and diet/exercise regimens. Together, the recent findings presented in this review serve as evidence to support the therapeutic treatment of MetS through diet.
C1 [Andersen, Catherine J.; Fernandez, Maria Luz] Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
C3 University of Connecticut
RP Fernandez, ML (corresponding author), Univ Connecticut, Dept Nutr Sci, 3624 Horsebarn Rd Ext,Unit 4017, Storrs, CT 06269 USA.
EM maria-luz.fernandez@uconn.edu
OI Andersen, Catherine/0000-0001-9774-5030
CR Abete I, 2010, NUTR REV, V68, P214, DOI 10.1111/j.1753-4887.2010.00280.x
   Ahluwalia N, 2013, DIABETES METAB, V39, P99, DOI 10.1016/j.diabet.2012.08.007
   Akter S, 2013, NUTR RES, V33, P286, DOI 10.1016/j.nutres.2013.01.009
   Al-Sarraj T, 2010, METAB SYNDR RELAT D, V8, P39, DOI 10.1089/met.2009.0035
   Al-Sarraj T, 2009, J NUTR, V139, P1667, DOI 10.3945/jn.109.109603
   Almoosawi S, 2013, INT J OBESITY, V37, P725, DOI 10.1038/ijo.2012.103
   Andersen CJ, 2013, LIPIDS, V48, P557, DOI 10.1007/s11745-013-3780-8
   Aukema HM, 2013, BRIT J NUTR, V110, P11, DOI 10.1017/S0007114512004606
   Baek SH, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057930
   Baik I, 2008, AM J CLIN NUTR, V87, P1455, DOI 10.1093/ajcn/87.5.1455
   Barona J, 2012, J NUTR, V142, P1626, DOI 10.3945/jn.112.162743
   Barquera S, 2013, GLOBALIZATION HEALTH, V9, DOI 10.1186/1744-8603-9-3
   Barrios-Ramos JP, 2012, J SCI FOOD AGR, V92, P2349, DOI 10.1002/jsfa.5637
   Baudrand R, 2014, CLIN ENDOCRINOL, V80, P677, DOI 10.1111/cen.12225
   Baxheinrich A, 2012, BRIT J NUTR, V108, P682, DOI 10.1017/S0007114512002875
   Bédard A, 2012, BRIT J NUTR, V108, P1428, DOI 10.1017/S0007114511006969
   Berndt J, 2008, EXP CLIN ENDOCR DIAB, V116, P203, DOI 10.1055/s-2007-993148
   Beulens JWJ, 2004, J LIPID RES, V45, P1716, DOI 10.1194/jlr.M400109-JLR200
   Beydoun MA, 2011, J NUTR, V141, P903, DOI 10.3945/jn.110.136580
   Bilbis LS, 2012, BIOCHEM RES INT, V2012, DOI 10.1155/2012/678582
   Blesso CN, 2013, J CLIN LIPIDOL, V7, P463, DOI 10.1016/j.jacl.2013.03.008
   Blesso CN, 2013, METABOLISM, V62, P400, DOI 10.1016/j.metabol.2012.08.014
   Blesso CN, 2013, FOOD FUNCT, V4, P213, DOI 10.1039/c2fo30154g
   Boudreau DM, 2009, METAB SYNDR RELAT D, V7, P305, DOI 10.1089/met.2008.0070
   Browning JD, 2011, AM J CLIN NUTR, V93, P1048, DOI 10.3945/ajcn.110.007674
   Cahova M, 2012, J NUTR METAB, V2012, DOI 10.1155/2012/757205
   Camargo A, 2013, J NUTR BIOCHEM, V24, P318, DOI 10.1016/j.jnutbio.2012.06.014
   Carvalho RF, 2012, VASC HEALTH RISK MAN, V8, P661, DOI 10.2147/VHRM.S37385
   Chan DC, 2008, EUR J CLIN INVEST, V38, P743, DOI 10.1111/j.1365-2362.2008.02019.x
   Chen CC, 2012, NUTR RES, V32, P24, DOI 10.1016/j.nutres.2011.11.004
   Chen JJ, 2012, BRIT J NUTR, V107, P1429, DOI 10.1017/S0007114511004491
   Cloetens L, 2012, NUTR REV, V70, P444, DOI 10.1111/j.1753-4887.2012.00494.x
   Cornier MA, 2008, ENDOCR REV, V29, P777, DOI 10.1210/er.2008-0024
   Cruz-Teno C, 2012, MOL NUTR FOOD RES, V56, P854, DOI 10.1002/mnfr.201200096
   Czernichow S, 2009, AM J CLIN NUTR, V90, P329, DOI 10.3945/ajcn.2009.27635
   D'Aversa F, 2013, INTERN EMERG MED, V8, pS11, DOI 10.1007/s11739-013-0916-z
   Dall'alba V, 2013, BR J NUTR, DOI [10.1017/S000711 4513001025, DOI 10.1017/S000711]
   Damsgaard C.T., 2013, BR J NUTR, P1
   de la Iglesia R, 2013, INT J MOL SCI, V14, P6903, DOI 10.3390/ijms14046903
   Defoort C, 2011, PUBLIC HEALTH NUTR, V14, P2302, DOI 10.1017/S1368980011002552
   den Boer A.T., 2013, Nutr Metab Cardiovasc Dis
   Dixit VD, 2008, J LEUKOCYTE BIOL, V84, P882, DOI 10.1189/jlb.0108028
   Dutheil F, 2013, INT J CARDIOL, V168, P3634, DOI 10.1016/j.ijcard.2013.05.012
   Dutheil F, 2012, NUTR J, V11, DOI 10.1186/1475-2891-11-72
   Elizondo-Montemayor L, 2013, J HUM NUTR DIET, V26, P82, DOI 10.1111/jhn.12070
   Elmadhun NY, 2012, SURGERY, V152, P414, DOI 10.1016/j.surg.2012.06.014
   Estruch R, 2013, NEW ENGL J MED, V368, P1279, DOI 10.1056/NEJMoa1200303
   Fan AZ, 2008, J CLIN ENDOCR METAB, V93, P3833, DOI 10.1210/jc.2007-2788
   Feldeisen SE, 2007, APPL PHYSIOL NUTR ME, V32, P46, DOI 10.1139/h06-101
   Fulgoni VL, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-1
   Galleano M, 2012, ANN NY ACAD SCI, V1259, P87, DOI 10.1111/j.1749-6632.2012.06511.x
   Gillingham LG, 2011, LIPIDS, V46, P209, DOI 10.1007/s11745-010-3524-y
   Gonzalez-Quintela A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054600
   Grundy SM, 2007, J CLIN ENDOCR METAB, V92, P399, DOI 10.1210/jc.2006-0513
   Huang HY, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/943020
   Jans A, 2012, METABOLISM, V61, P1554, DOI 10.1016/j.metabol.2012.04.003
   Jiménez-Gómez Y, 2010, J NUTR, V140, P1595, DOI 10.3945/jn.109.120816
   Jones J. L., 2011, British Journal of Medicine and Medical Research, V1, P356
   Jones JL, 2012, METABOLISM, V61, P366, DOI 10.1016/j.metabol.2011.07.013
   Jones JL, 2011, J CLIN LIPIDOL, V5, P188, DOI 10.1016/j.jacl.2011.03.002
   Jones KW, 2013, EUR J CLIN NUTR, V67, P371, DOI 10.1038/ejcn.2013.52
   Kang HL, 2006, AM J GASTROENTEROL, V101, P2247, DOI 10.1111/j.1572-0241.2006.00719.x
   Katcher HI, 2008, AM J CLIN NUTR, V87, P79, DOI 10.1093/ajcn/87.1.79
   Kesse-Guyot E, 2013, NUTR METAB CARDIOVAS, V23, P677, DOI 10.1016/j.numecd.2012.02.005
   Kim J, 2013, J HUM NUTR DIET, V26, P171, DOI 10.1111/jhn.12098
   Kim J, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-489
   Kolehmainen M, 2012, MOL NUTR FOOD RES, V56, P1501, DOI 10.1002/mnfr.201200195
   Kontush A, 2006, PHARMACOL REV, V58, P342, DOI 10.1124/pr.58.3.1
   Kuroki Y, 2012, EUR J INTERN MED, V23, pE199, DOI 10.1016/j.ejim.2012.08.002
   Laso N, 2007, BRIT J NUTR, V98, P860, DOI 10.1017/S0007114507750882
   Leber B, 2012, EUR J CLIN NUTR, V66, P1110, DOI 10.1038/ejcn.2012.103
   Li YR, 2013, ASIA PAC J CLIN NUTR, V22, P60, DOI 10.6133/apjcn.2013.22.1.06
   Lofgren IE, 2005, J AM COLL NUTR, V24, P486, DOI 10.1080/07315724.2005.10719494
   Lopez-Legarrea P, 2013, NUTR METAB, V10, DOI 10.1186/1743-7075-10-22
   Madani Z, 2012, INT J MOL MED, V29, P311, DOI 10.3892/ijmm.2011.836
   Madero M, 2011, METABOLISM, V60, P1551, DOI 10.1016/j.metabol.2011.04.001
   Mäkelä SM, 2008, ALCOHOL CLIN EXP RES, V32, P991, DOI 10.1111/j.1530-0277.2008.00660.x
   Malin SK, 2012, ANN NUTR METAB, V61, P135, DOI 10.1159/000342084
   Medjakovic S, 2013, FOOD FUNCT, V4, P19, DOI 10.1039/c2fo30034f
   Melanson KJ, 2012, NUTR J, V11, DOI 10.1186/1475-2891-11-57
   Menegotto G, 2013, BR J NUTR, DOI [10.1017/S0007114 513000846, DOI 10.1017/S0007114]
   Meneses ME, 2011, MOL NUTR FOOD RES, V55, P1759, DOI 10.1002/mnfr.201100200
   Merino J, 2013, BRIT J NUTR, V109, P1241, DOI 10.1017/S0007114512003091
   Min C, 2012, NUTR RES PRACT, V6, P61, DOI 10.4162/nrp.2012.6.1.61
   Mollard RC, 2012, BRIT J NUTR, V108, pS111, DOI 10.1017/S0007114512000712
   Monti LD, 2013, METABOLISM, V62, P255, DOI 10.1016/j.metabol.2012.08.004
   Mozumdar A, 2011, DIABETES CARE, V34, P216, DOI 10.2337/dc10-0879
   Nazare JA, 2013, J NUTR, V143, P1074, DOI 10.3945/jn.113.175273
   Ng TWK, 2007, DIABETES CARE, V30, P2945, DOI 10.2337/dc07-0768
   Ng TWK, 2010, CLIN SCI, V118, P79, DOI 10.1042/CS20090110
   Nordmann AJ, 2011, AM J MED, V124, P841, DOI 10.1016/j.amjmed.2011.04.024
   Ouellet V, 2008, J NUTR, V138, P2386, DOI 10.3945/jn.108.092346
   Ouellet V, 2007, DIABETES CARE, V30, P2816, DOI 10.2337/dc07-0273
   Papathanasopoulos A, 2010, GASTROENTEROLOGY, V138, P65, DOI 10.1053/j.gastro.2009.11.045
   Park DY, 2013, WORLD J GASTROENTERO, V19, P274, DOI 10.3748/wjg.v19.i2.274
   Pena-Orihuela P., 2013, J NUTR BIOCH, DOI [10.1016/j.jnutbio.2013.02.012, DOI 10.1016/J.JNUTBI0.2013.02.012]
   Poudyal H, 2013, J NUTR BIOCHEM, V24, P1381, DOI 10.1016/j.jnutbio.2012.11.006
   Poudyal H, 2013, J NUTR BIOCHEM, V24, P1041, DOI 10.1016/j.jnutbio.2012.07.014
   Puchau B, 2010, NUTRITION, V26, P534, DOI 10.1016/j.nut.2009.06.017
   Rayssiguier Y, 2010, MAGNESIUM RES, V23, P73, DOI 10.1684/mrh.2010.0208
   Richard C, 2011, NUTR METAB CARDIOVAS, V21, P628, DOI 10.1016/j.numecd.2010.01.012
   Richard C, 2013, OBESITY, V21, P51, DOI 10.1002/oby.20239
   Richard C, 2013, J LIPID RES, V54, P232, DOI 10.1194/jlr.M029934
   Richard C, 2012, BRIT J NUTR, V107, P705, DOI 10.1017/S0007114511003436
   Rideout TC, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-56
   Rimm EB, 1999, BMJ-BRIT MED J, V319, P1523, DOI 10.1136/bmj.319.7224.1523
   Riso P, 2013, EUR J NUTR, V52, P949, DOI 10.1007/s00394-012-0402-9
   Robertson MD, 2012, J CLIN ENDOCR METAB, V97, P3326, DOI 10.1210/jc.2012-1513
   Robich MP, 2012, J AM COLL SURGEONS, V215, P681, DOI 10.1016/j.jamcollsurg.2012.06.417
   Robinson LE, 2013, LIPIDS, V48, P319, DOI 10.1007/s11745-013-3774-6
   Samara A, 2013, NUTRITION, V29, P519, DOI 10.1016/j.nut.2012.08.013
   Schini-Kerth VB, 2010, PFLUG ARCH EUR J PHY, V459, P853, DOI 10.1007/s00424-010-0806-4
   Shai I, 2008, NEW ENGL J MED, V359, P229, DOI 10.1056/NEJMoa0708681
   Shi L, 2013, BRIT J NUTR, V109, P263, DOI 10.1017/S000711451200116X
   Siri-Tarino PW, 2010, AM J CLIN NUTR, V91, P535, DOI 10.3945/ajcn.2009.27725
   Solga S, 2004, DIGEST DIS SCI, V49, P1578, DOI 10.1023/B:DDAS.0000043367.69470.b7
   Tang MH, 2013, OBESITY, V21, pE204, DOI 10.1002/oby.20078
   Mitjavila MT, 2013, CLIN NUTR, V32, P172, DOI 10.1016/j.clnu.2012.08.002
   Tomada I, 2013, AGE DORDR, V1, P541
   van der Gaag MS, 1999, ATHEROSCLEROSIS, V147, P405, DOI 10.1016/S0021-9150(99)00243-9
   van Meijl LEC, 2008, NUTR RES REV, V21, P148, DOI 10.1017/S0954422408116997
   Vendrame S, 2013, J NUTR BIOCHEM, V24, P1508, DOI 10.1016/j.jnutbio.2012.12.010
   Vendrame S, 2011, J AGR FOOD CHEM, V59, P12815, DOI 10.1021/jf2028686
   Volek JS, 2008, PROG LIPID RES, V47, P307, DOI 10.1016/j.plipres.2008.02.003
   Volek JS, 2009, METABOLISM, V58, P1769, DOI 10.1016/j.metabol.2009.06.005
   Volek JS, 2009, LIPIDS, V44, P297, DOI 10.1007/s11745-008-3274-2
   Wang X, 2012, NUTR J, V11, DOI 10.1186/1475-2891-11-20
   Watt MJ, 2005, DIABETOLOGIA, V48, P105, DOI 10.1007/s00125-004-1598-x
   Willett WC, 2012, J INTERN MED, V272, P13, DOI 10.1111/j.1365-2796.2012.02553.x
   Wood RJ, 2007, METABOLISM, V56, P58, DOI 10.1016/j.metabol.2006.08.021
   Xu XH, 2012, LIFE SCI, V90, P1001, DOI 10.1016/j.lfs.2012.05.016
   Yamaoka K, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-138
   Yancy WS, 2004, ANN INTERN MED, V140, P769, DOI 10.7326/0003-4819-140-10-200405180-00006
   Yoo SR, 2013, OBESITY SILVER SPRIN, DOI [10.1002/oby.20428, DOI 10.1002/0BY.20428]
   Zaki ME, 2012, ANN SAUDI MED, V32, P603, DOI 10.5144/0256-4947.2012.603
   Zern TL, 2005, J NUTR, V135, P2291, DOI 10.1093/jn/135.10.2291
NR 136
TC 111
Z9 127
U1 0
U2 74
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1389-9155
EI 1573-2606
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD SEP
PY 2013
VL 14
IS 3
BP 241
EP 254
DI 10.1007/s11154-013-9251-y
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 224JP
UT WOS:000324881200004
PM 23943309
DA 2025-06-11
ER

PT J
AU Nehmi, V
   de Freitas, JA
   Franco, LAM
   Fonseca, JVD
   Martins, RCR
   Santamarina, AB
   Murata, GM
   Sabino, EC
   Souza, E
   Ferreira, MT
   Otoch, JP
   Pessoa, AFM
AF Nehmi-Filho, Victor
   de Freitas, Jessica Alves
   Franco, Lucas Augusto Moyses
   Fonseca, Joyce Vanessa da Silva
   Martins, Roberta Cristina Ruedas
   Santamarina, Aline Boveto
   Murata, Gilson Masahiro
   Sabino, Ester Cerdeira
   Souza, Erica
   Ferreira, Matthew Thomas
   Otoch, Jose Pinhata
   Pessoa, Ana Flavia Marcal
TI Novel Nutraceutical (silymarin, yeast β-glucan, prebiotics, and
   minerals) shifts gut microbiota and restores large intestine histology
   of diet-induced metabolic syndrome mice
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Nutraceutical; Gut; Microbiota; Silymarin; Prebiotics; Metabolic
   syndrome
ID OBESITY; BENEFITS; HEALTH; MUCINS
AB Gut dysbiosis contributes to chronic inflammation and oxidative stress associated with metabolic syndrome, and non-pharmacological, health-promoting supplements like nutraceuticals have been studied and used as a way to prevent or treat several illnesses. Thus, male C57BL/6 mice were divided into the following groups: control (CTL) _Vehicle and CTL_Nutraceutical; high-fat diet (HFD)_Vehicle, HFD_Nutraceutical, HFD_Nutraceutical_S, and isolated compounds. The vehicle and experimental formulations were administered by gavage once a day for four weeks with a high-fat diet simultaneously. In addition, we evaluated the composition of the fecal microbiota by partial 16S rRNA sequences directly amplified using a bacterial/archaeal primer set 515F/806R, and large intestine histomorphology was examined by H & E (Hematoxylin and Eosin), Masson's trichrome (MT), and PAS-AB (Periodic Acid Schiff-Alcian Blue) stains in these groups of mice. After four weeks of supplementation, only the Novel Nutraceutical supplement was able to increase & alpha; and & beta;-diversities, modulate the relative abundance in gut microbiota, decrease Firmicutes, and increase Bacteroidetes bacteria, meanwhile recovering the large intestine's (colon) histomorphology in CTL and HFD groups.
C1 [Nehmi-Filho, Victor; de Freitas, Jessica Alves; Santamarina, Aline Boveto; Otoch, Jose Pinhata; Pessoa, Ana Flavia Marcal] Univ Sao Paulo, Dept Surg, Med Sch, Nat Prod & Derivat Lab LIM 26, Sao Paulo, SP, Brazil.
   [Nehmi-Filho, Victor; de Freitas, Jessica Alves; Otoch, Jose Pinhata; Pessoa, Ana Flavia Marcal] Efeom Nutr S A, Res & Dev, Sao Paulo, SP, Brazil.
   [Franco, Lucas Augusto Moyses; Martins, Roberta Cristina Ruedas; Sabino, Ester Cerdeira] Univ Sao Paulo, Med Sch, Med Parasitol Lab LIM 46, Inst Trop Med,Dept Infect & Parasit Dis, Sao Paulo, SP, Brazil.
   [Fonseca, Joyce Vanessa da Silva] Univ Sao Paulo, Med Sch, Med Res Lab Bacteriol & Antimicrobial Resistance L, Dept Infect & Parasit Dis,Inst Trop Med, Sao Paulo, SP, Brazil.
   [Murata, Gilson Masahiro] Univ Sao Paulo, Med Sch, Clin Med Dept, Lab Med Invest LIM 29, Sao Paulo, SP, Brazil.
   [Souza, Erica] Monte Azul Ambulatorio, Sao Paulo, SP, Brazil.
   [Ferreira, Matthew Thomas] Hosp Clin Univ Sao Paulo, Med Sch, Ctr Translat Res Oncol, Inst Canc Estado Sao Paulo ICESP, Sao Paulo, SP, Brazil.
   [Pessoa, Ana Flavia Marcal] Nat Prod Comm, Brazilian Acad Consortium Integrat Hlth CABSIN, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade de
   Sao Paulo; Universidade de Sao Paulo; Universidade de Sao Paulo
RP Pessoa, AFM (corresponding author), Univ Sao Paulo, Dept Surg, Med Sch, Nat Prod & Derivat Lab LIM 26, Sao Paulo, SP, Brazil.; Pessoa, AFM (corresponding author), Efeom Nutr S A, Res & Dev, Sao Paulo, SP, Brazil.; Pessoa, AFM (corresponding author), Nat Prod Comm, Brazilian Acad Consortium Integrat Hlth CABSIN, Sao Paulo, Brazil.
EM victor@nehmi.com.br; jessicaalvesdefreitas@gmail.com;
   lucasamfranco@hotmail.com; joycevanesf@gmail.com;
   betacristina@gmail.com; ana.pessoa@fm.usp.br; gilson.murata@usp.br;
   sabinoec@gmail.com; net.erica@gmail.com; matthew.t.ferreira@gmail.com;
   pinhata@usp.br; ana.pessoa@fm.usp.br
RI Ferreira, Matthew/ABE-8683-2020; Pessoa, Ana Flavia/P-7501-2018; Murata,
   Gilson Masahiro/E-4569-2015; Santamarina, Aline/AAI-7639-2020; Sabino,
   Ester/F-7750-2010
FU Efeom Nutrition S.A. [01/04-21]
FX Funding This study was financed by Efeom Nutrition S.A. (01/04-21) .
CR Abenavoli L, 2018, PHYTOTHER RES, V32, P2202, DOI 10.1002/ptr.6171
   Abou Nehmi V, 2021, J INTEGR MED-JIM, V19, P439, DOI 10.1016/j.joim.2021.05.002
   Ahn JR, 2022, PEDIAT ALLERG IMM-UK, V33, DOI 10.1111/pai.13678
   Aliluev A, 2021, NAT METAB, V3, P1202, DOI 10.1038/s42255-021-00458-9
   Anderson JW, 2009, NUTR REV, V67, P188, DOI 10.1111/j.1753-4887.2009.00189.x
   Berg G, 2020, MICROBIOME, V8, DOI 10.1186/s40168-020-00875-0
   Boer CG, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-12873-4
   Bokulich NA, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0470-z
   Bolyen E, 2019, NAT BIOTECHNOL, V37, P852, DOI 10.1038/s41587-019-0209-9
   Boutari Chrysoula, 2022, Metabolism, V133, P155217, DOI 10.1016/j.metabol.2022.155217
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Canfora EE, 2017, GASTROENTEROLOGY, V153, P87, DOI 10.1053/j.gastro.2017.03.051
   Caporaso JG, 2011, P NATL ACAD SCI USA, V108, P4516, DOI 10.1073/pnas.1000080107
   Chen ZL, 2021, JAMA NETW OPEN, V4, DOI 10.1001/jamanetworkopen.2021.18811
   Chi L, 2021, GUT MICROBES, V13, DOI 10.1080/19490976.2021.1921912
   Christensen L, 2019, J NUTR, V149, P2174, DOI 10.1093/jn/nxz198
   Cirstea M, 2018, CELL HOST MICROBE, V23, P10, DOI 10.1016/j.chom.2017.12.008
   Clarke SF, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0065790
   Cornick S, 2015, TISSUE BARRIERS, V3, DOI 10.4161/21688370.2014.982426
   Dabke K, 2019, J CLIN INVEST, V129, P4050, DOI 10.1172/JCI129194
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   Del Chierico F, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01210
   Desai MS, 2016, CELL, V167, P1339, DOI 10.1016/j.cell.2016.10.043
   Dong A, 2022, J CANCER PREV, V27, P50, DOI 10.15430/JCP.2022.27.1.50
   EFSA, 2017, Summary report, DOI DOI 10.2903/SP.EFSA.2017.E15121
   El Menofy NG, 2022, MICROORGANISMS, V10, DOI 10.3390/microorganisms10091820
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   FAITH DP, 1992, BIOL CONSERV, V61, P1, DOI 10.1016/0006-3207(92)91201-3
   Fernandes R, 2016, J CLIN GASTROENTEROL, V50, P208, DOI 10.1097/MCG.0000000000000328
   Finlayson A, 2015, WORLD J GASTRO ENDOS, V7, P1103, DOI [10.4291/wjgp.v6.i4.110, 10.4253/wjge.v7.i13.1103]
   Cano PG, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041079
   Gong Y, 2019, MAR DRUGS, V17, DOI 10.3390/md17050255
   Guo S, 2020, MOLECULES, V25, DOI 10.3390/molecules25174001
   He MQ, 2017, CELL BIOSCI, V7, DOI 10.1186/s13578-017-0183-1
   Imhann F, 2016, GUT, V65, P740, DOI 10.1136/gutjnl-2015-310376
   Jain Parul, 2014, J Nat Sci Biol Med, V5, P404, DOI 10.4103/0976-9668.136207
   Janssen S, 2018, MSYSTEMS, V3, DOI 10.1128/mSystems.00021-18
   Jayasinghe TN, 2016, FRONT CELL INFECT MI, V6, DOI 10.3389/fcimb.2016.00015
   Jiao N, 2018, PHYSIOL GENOMICS, V50, P244, DOI 10.1152/physiolgenomics.00114.2017
   Kim Young S, 2010, Curr Gastroenterol Rep, V12, P319, DOI 10.1007/s11894-010-0131-2
   Krajmalnik-Brown R, 2012, NUTR CLIN PRACT, V27, P201, DOI 10.1177/0884533611436116
   Kumar H, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8121855
   La Reau AJ, 2016, MICROB GENOMICS, V2, DOI 10.1099/mgen.0.000099
   Lakshmanan AP, 2021, NUTRIENTS, V13, DOI 10.3390/nu13030836
   Lippert K, 2017, BENEF MICROBES, V8, P545, DOI 10.3920/BM2016.0184
   López-Almela I, 2021, GUT MICROBES, V13, P1, DOI 10.1080/19490976.2020.1865706
   Mahlapuu M, 2016, FRONT CELL INFECT MI, V6, DOI 10.3389/fcimb.2016.00194
   Maloy KJ, 2011, NATURE, V474, P298, DOI 10.1038/nature10208
   Mandal Siddhartha, 2015, Microbial Ecology in Health and Disease, V26, P27663, DOI 10.3402/mehd.v26.27663
   Pessoa AFM, 2016, WOUND REPAIR REGEN, V24, P981, DOI 10.1111/wrr.12486
   Marçal-Pessoa AF, 2015, BIOL RES, V48, DOI 10.1186/0717-6287-48-3
   Maseda D, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.01153
   Massier L, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.616506
   Matsushita N, 2016, SCAND J IMMUNOL, V83, P109, DOI 10.1111/sji.12397
   Mirarab S, 2012, BIOCOMPUT-PAC SYM, P247
   Moles L, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061654
   Moreira GV, 2018, J NUTR BIOCHEM, V62, P143, DOI 10.1016/j.jnutbio.2018.07.009
   Nair Anroop B, 2016, J Basic Clin Pharm, V7, P27, DOI 10.4103/0976-0105.177703
   Nehmi V, 2023, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.1089938
   Owen CD, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-02109-8
   Paone P, 2020, GUT, V69, P2232, DOI 10.1136/gutjnl-2020-322260
   Postler TS, 2017, CELL METAB, V26, P110, DOI 10.1016/j.cmet.2017.05.008
   Rajani C, 2018, CLIN SCI, V132, P791, DOI 10.1042/CS20171328
   Rasmussen HE, 2009, J APPL MICROBIOL, V107, P1108, DOI 10.1111/j.1365-2672.2009.04288.x
   Samuelsen ABC, 2014, MOL NUTR FOOD RES, V58, P183, DOI 10.1002/mnfr.201300338
   Santamarina AB, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11030447
   Santos-Marcos JA, 2019, J NUTR BIOCHEM, V70, P1, DOI 10.1016/j.jnutbio.2019.03.017
   Schröder BO, 2020, J BIOL CHEM, V295, P15712, DOI 10.1074/jbc.RA120.015771
   Schroeder BO, 2018, CELL HOST MICROBE, V23, P27, DOI 10.1016/j.chom.2017.11.004
   Sender R, 2016, PLOS BIOL, V14, DOI 10.1371/journal.pbio.1002533
   Serino M, 2012, GUT, V61, P543, DOI 10.1136/gutjnl-2011-301012
   Shen L, 2019, APPL MICROBIOL BIOT, V103, P7141, DOI 10.1007/s00253-019-09950-5
   Shin NR, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.665881
   Simon JC, 2019, MICROBIOME, V7, DOI 10.1186/s40168-019-0619-4
   Singh RK, 2017, J TRANSL MED, V15, DOI 10.1186/s12967-017-1175-y
   Skrypnik K, 2018, J SCI FOOD AGR, V98, P2449, DOI 10.1002/jsfa.8724
   Song G, 2021, FOOD NUTR RES, V65, DOI 10.29219/fnr.v65.5589
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   Tseng CH, 2019, J FORMOS MED ASSOC, V118, pS3, DOI 10.1016/j.jfma.2018.07.009
   Vadivazhagan K, 2022, CUREUS J MED SCIENCE, V14, DOI 10.7759/cureus.32033
   Valles-Colomer M, 2019, NAT MICROBIOL, V4, P623, DOI 10.1038/s41564-018-0337-x
   Vamanu E, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.00492
   van de Vlekkert D, 2020, BIO-PROTOCOL, V10, DOI 10.21769/BioProtoc.3629
   Van den Abbeele P, 2013, ISME J, V7, P949, DOI 10.1038/ismej.2012.158
   van der Hee B, 2021, TRENDS MICROBIOL, V29, P700, DOI 10.1016/j.tim.2021.02.001
   Vázquez-Baeza Y, 2013, GIGASCIENCE, V2, DOI 10.1186/2047-217X-2-16
   Vinderola G, 2022, FOODS, V11, DOI 10.3390/foods11081077
   Wolf KJ, 2012, CURR OBES REP, V1, DOI 10.1007/s13679-011-0001-8
   Xu SY, 2022, ANIMALS-BASEL, V12, DOI 10.3390/ani12172202
   Yang JP, 2021, GUT MICROBES, V13, DOI 10.1080/19490976.2021.1987783
   Zheng ZB, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.690138
   Zhou WN, 2018, EXP BIOL MED, V243, P826, DOI 10.1177/1535370218777762
NR 93
TC 9
Z9 9
U1 0
U2 15
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD AUG
PY 2023
VL 107
AR 105671
DI 10.1016/j.jff.2023.105671
EA JUL 2023
PG 13
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA N0BR4
UT WOS:001033779400001
OA gold
DA 2025-06-11
ER

PT J
AU Hur, J
   Dauch, JR
   Hinder, LM
   Hayes, JM
   Backus, C
   Pennathur, S
   Kretzler, M
   Brosius, FC
   Feldman, EL
AF Hur, Junguk
   Dauch, Jacqueline R.
   Hinder, Lucy M.
   Hayes, John M.
   Backus, Carey
   Pennathur, Subramaniam
   Kretzler, Matthias
   Brosius, Frank C., III
   Feldman, Eva L.
TI The Metabolic Syndrome and Microvascular Complications in a Murine Model
   of Type 2 Diabetes
SO DIABETES
LA English
DT Article
ID DB/DB MOUSE; NEUROPATHY; NERVE; ABNORMALITIES; PIOGLITAZONE;
   LIPOPROTEINS; RECEPTOR; INJURY; VOLUME; RAT
AB To define the components of the metabolic syndrome that contribute to diabetic polyneuropathy (DPN) in type 2 diabetes (mellitus (T2DM), we treated the BKS db/db mouse, an established murine model of T2DM and the metabolic syndrome, with the thiazolidinedione class drug pioglitazone. Pioglitazone treatment of BKS db/db Mice produced a significant Weight gain, restored glycemic Control, and normalized measures of serum oxidative stress and triglycerides but had no effect on LDLs or total Cholesterol. Moreover, although pioglitazone treatment normalized renal function, it had no effect on measures of large myelinated nerve fibers, specifically sural or sciatic nerve conduction velocities, but significantly improved Measures of small unmyelinated nerve fiber architecture and function. Analyses of gene expression arrays of large myelinated sciatic nerves from pioglitazone-treated animals revealed an unanticipated increase in genes related to adipogenesis, adipokine signaling, and lipoprotein signaling, which likely contributed to the blunted therapeutic response. Similar analyses Of dorsal root ganglion neurons revealed a salutary effect of pioglitazone on pathways related to defense and cytokine production. These data suggest differential susceptibility of small and large nerve fibers to specific metabolic impairments associated with T2DM and provide the basis for discussion of new treatment paradigms for individuals with T2DM and DPN.
C1 [Hur, Junguk; Dauch, Jacqueline R.; Hinder, Lucy M.; Hayes, John M.; Backus, Carey; Feldman, Eva L.] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA.
   [Hur, Junguk] Univ N Dakota, Sch Med & Hlth Sci, Dept Basic Sci, Grand Forks, ND 58201 USA.
   [Pennathur, Subramaniam; Kretzler, Matthias; Brosius, Frank C., III] Univ Michigan, Dept Internal Med, Div Nephrol, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; University of
   North Dakota Grand Forks; University of Michigan System; University of
   Michigan
RP Feldman, EL (corresponding author), Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA.
EM efeldman@med.umich.edu
RI Hur, Junguk/J-6229-2019; Pennathur, Subramaniam/O-7032-2017
OI Hinder, Lucy/0000-0002-5206-8010; Pennathur,
   Subramaniam/0000-0003-3628-6883; Hur, Junguk/0000-0002-0736-2149;
   Feldman, Eva/0000-0002-9162-2694
FU National Institutes of Health [1DP3-DK-094292, 1R-24082841]; JDRF;
   American Diabetes Association; Program for Neurology Research and
   Discovery; A. Alfred Taubman Medical Research Institute; National
   Institute of Diabetes and Digestive and Kidney Diseases [P30DK092926,
   P30DK020572, P30DK081943] Funding Source: NIH RePORTER
FX Funding was provided by the National Institutes of Health
   (1DP3-DK-094292,1R-24082841 to M.K., F.C.B., and ELF.), JDRF
   (postdoctoral fellowships to J.H. and L.M.H.), the American Diabetes
   Association, the Program for Neurology Research and Discovery, and the
   A. Alfred Taubman Medical Research Institute.
CR Alberti G., 2006, The IDF consensus worldwide definition of the metabolic syndrome
   [Anonymous], 2014, NAT DIAB STAT REP ES
   Betz B, 2014, NEPHRON EXP NEPHROL, V126, P191, DOI 10.1159/000363300
   Biessels GJ, 2002, EUR J PHARMACOL, V441, P1, DOI 10.1016/S0014-2999(02)01486-3
   Brosius Laboratory, 2008, DET POD NUMB DENS RO
   Callaghan BC, 2012, COCHRANE DB SYST REV, V6
   Callaghan B, 2013, ANN NEUROL, V74, P397, DOI 10.1002/ana.23986
   Calvo D, 1998, J LIPID RES, V39, P777
   Cariou B, 2012, TRENDS ENDOCRIN MET, V23, P205, DOI 10.1016/j.tem.2012.03.001
   Cheng HT, 2009, J NEUROPATH EXP NEUR, V68, P1229, DOI 10.1097/NEN.0b013e3181bef710
   Cohen MP, 1996, EXP NEPHROL, V4, P166
   Cortez Melissa, 2014, Handb Clin Neurol, V126, P109, DOI 10.1016/B978-0-444-53480-4.00009-6
   Dai MH, 2005, NUCLEIC ACIDS RES, V33, DOI 10.1093/nar/gni179
   ENDEMANN G, 1993, J BIOL CHEM, V268, P11811
   Hempe J, 2012, LAB ANIM-UK, V46, P32, DOI 10.1258/la.2011.010165
   Hinder LM, 2014, ANTIOXID REDOX SIGN, V21, P588, DOI 10.1089/ars.2013.5248
   Hoyert Donna L, 2012, Natl Vital Stat Rep, V61, P1
   Huang DW, 2009, NAT PROTOC, V4, P44, DOI 10.1038/nprot.2008.211
   Hur J, 2011, BRAIN, V134, P3222, DOI 10.1093/brain/awr228
   Jain V, 2009, PHARMACOL RES, V59, P385, DOI 10.1016/j.phrs.2009.02.001
   Keller JN, 2000, EXP NEUROL, V161, P621, DOI 10.1006/exnr.1999.7276
   Ko GJ, 2008, NEPHROL DIAL TRANSPL, V23, P2750, DOI 10.1093/ndt/gfn157
   Kobayashi K, 2000, METABOLISM, V49, P22, DOI 10.1016/S0026-0495(00)90588-2
   MAHLEY RW, 1984, J LIPID RES, V25, P1277
   Murphy KT, 2013, AM J PHYSIOL-ENDOC M, V304, pE1338, DOI 10.1152/ajpendo.00021.2013
   Nowicki M, 2012, J NEUROSCI RES, V90, P122, DOI 10.1002/jnr.22728
   O'Brien PD, 2014, ILAR J, V54, P259, DOI 10.1093/ilar/ilt052
   Oltman CL, 2008, DIABETES OBES METAB, V10, P64, DOI 10.1111/j.1463-1326.2007.00814.x
   Pande M, 2011, DIABETES, V60, P1981, DOI 10.2337/db10-1541
   Puri V, 2008, P NATL ACAD SCI USA, V105, P7833, DOI 10.1073/pnas.0802063105
   Qiang X, 1998, DIABETOLOGIA, V41, P1321, DOI 10.1007/s001250051072
   ROBERTSON DM, 1980, DIABETES, V29, P60, DOI 10.2337/diabetes.29.1.60
   Sahakyan K, 2011, DIABETES CARE, V34, P649, DOI 10.2337/dc10-1712
   Sanden SK, 2003, J AM SOC NEPHROL, V14, P2484, DOI 10.1097/01.ASN.0000089829.45296.7C
   Sartor MA, 2006, BMC BIOINFORMATICS, V7, DOI 10.1186/1471-2105-7-538
   Shibata T, 2000, BRIT J PHARMACOL, V130, P495, DOI 10.1038/sj.bjp.0703328
   SIMA AAF, 1978, ACTA NEUROPATHOL, V41, P85, DOI 10.1007/BF00689757
   Sohn MW, 2013, J VASC SURG, V58, P1578, DOI 10.1016/j.jvs.2013.06.069
   Sullivan KA, 2007, NEUROBIOL DIS, V28, P276, DOI 10.1016/j.nbd.2007.07.022
   Tabet F, 2009, CLIN SCI, V116, P87, DOI 10.1042/CS20080106
   Tesch GH, 2011, AM J PHYSIOL-RENAL, V300, pF301, DOI 10.1152/ajprenal.00607.2010
   Vincent AM, 2009, J PERIPHER NERV SYST, V14, P257, DOI 10.1111/j.1529-8027.2009.00237.x
   Vincent AM, 2009, DIABETES, V58, P2376, DOI 10.2337/db09-0047
   Wu SC, 2007, VASC HEALTH RISK MAN, V3, P65
   Yamagishi SI, 2008, J NEUROCHEM, V104, P491, DOI 10.1111/j.1471-4159.2007.05050.x
   Zhang HY, 2008, AM J PHYSIOL-RENAL, V295, pF1071, DOI 10.1152/ajprenal.90208.2008
   Zhou L, 2013, AM J PHYSIOL-RENAL, V305, pF1491, DOI 10.1152/ajprenal.00004.2013
NR 47
TC 49
Z9 52
U1 0
U2 23
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD SEP
PY 2015
VL 64
IS 9
BP 3294
EP 3304
DI 10.2337/db15-0133
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CP9AE
UT WOS:000360185300028
PM 25979075
OA Green Published
DA 2025-06-11
ER

PT J
AU Hsu, HC
   Mountz, JD
AF Hsu, Hui-Chen
   Mountz, John D.
TI Metabolic syndrome, hormones, and maintenance of T cells during aging
SO CURRENT OPINION IN IMMUNOLOGY
LA English
DT Review
ID LIFE-SPAN; GUT MICROBIOTA; IMMUNE-SYSTEM; AGED MICE; OXIDATIVE STRESS;
   LEPTIN RECEPTOR; DNA-DAMAGE; OBESE GENE; IN-VIVO; INFLAMMATION
AB Although the phenotype of T-cell senescence has been extensively investigated, few studies have analyzed the factors that promote the generation and maintenance of naive and memory T cells that exist throughout the lifespan of the individuals. Unlike senescent T cells, naive and memory T cells are able to participate in useful immune responses as well as respond to new activation. Hormones such as leptin, ghrelin, insulin-like growth factor 1, IGFBP3, and cytokines, including IL-7, regulate both thymopoiesis and maintenance of naive T cells in the periphery. Although chronic viruses such as cytomegalovirus (CMV) are thought to drive T-cell senescence, other microbes may be important for the maintenance of nonsenescent T cells. Microbiota of the gut can induce metabolic syndrome as well as modulate T-cell development into specific subpopulations of effector cells. Finally, T-cell generation, maintenance, and apoptosis depend upon pathways of energy utilization within the T cells, which parallel those that regulate overall metabolism. Therefore, better understanding of metabolic syndrome, T-cell metabolism, hormones, and microbiota may lead to new insights into the maintenance of proper immune responses in old age.
C1 [Hsu, Hui-Chen; Mountz, John D.] Univ Alabama, Dept Med, Birmingham, AL 35294 USA.
   [Mountz, John D.] Vet Adm Med Ctr, Birmingham, AL 35233 USA.
C3 University of Alabama System; University of Alabama Birmingham; US
   Department of Veterans Affairs; Veterans Health Administration (VHA)
RP Mountz, JD (corresponding author), Univ Alabama, Dept Med, Birmingham, AL 35294 USA.
EM jdmountz@uab.edu
OI Hsu, Hui-Chen/0000-0002-0317-5725
FU NIH/NIA [PO1 AG022064]
FX This research was supported by NIH/NIA PO1 AG022064. We thank Ms. Carol
   Humber for excellent secretarial assistance.
CR Arai Y, 2008, J GERONTOL A-BIOL, V63, P1209, DOI 10.1093/gerona/63.11.1209
   Bäckhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Bartke A, 2005, ENDOCRINOLOGY, V146, P3718, DOI 10.1210/en.2005-0411
   Bartke A, 2008, AGING CELL, V7, P285, DOI 10.1111/j.1474-9726.2008.00387.x
   Beneke R, 2001, ONCOGENE, V20, P8136, DOI 10.1038/sj.onc.1205056
   CAMPFIELD LA, 1995, SCIENCE, V269, P546, DOI 10.1126/science.7624778
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Chang F, 2003, LEUKEMIA, V17, P590, DOI 10.1038/sj.leu.2402824
   Chehab NH, 1999, P NATL ACAD SCI USA, V96, P13777, DOI 10.1073/pnas.96.24.13777
   Chen J, 2010, MECH AGEING DEV, V131, P29, DOI 10.1016/j.mad.2009.11.003
   Dixit VD, 2007, J CLIN INVEST, V117, P2778, DOI 10.1172/JCI30248
   Dorshkind K, 2009, NAT REV IMMUNOL, V9, P57, DOI 10.1038/nri2471
   Feuerer M, 2009, NAT MED, V15, P930, DOI 10.1038/nm.2002
   Fontana L, 2010, SCIENCE, V328, P321, DOI 10.1126/science.1172539
   Frauwirth KA, 2002, IMMUNITY, V16, P769, DOI 10.1016/S1074-7613(02)00323-0
   Grimberg A, 2000, MOL GENET METAB, V70, P85, DOI 10.1006/mgme.2000.3008
   Gruver AL, 2008, J LEUKOCYTE BIOL, V84, P915, DOI 10.1189/jlb.0108025
   Gruver AL, 2009, J ENDOCRINOL, V203, P75, DOI 10.1677/JOE-09-0179
   Harrison DE, 2009, NATURE, V460, P392, DOI 10.1038/nature08221
   Holland AM, 2009, CURR OPIN IMMUNOL, V21, P454, DOI 10.1016/j.coi.2009.06.002
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Hsu HC, 2006, MECH AGEING DEV, V127, P231, DOI 10.1016/j.mad.2005.10.001
   Hsu HC, 2003, GENES IMMUN, V4, P402, DOI 10.1038/sj.gene.6363982
   Hsu HC, 2001, MECH AGEING DEV, V122, P1663, DOI 10.1016/S0047-6374(01)00279-2
   Hsu HC, 2001, MECH AGEING DEV, V122, P305, DOI 10.1016/S0047-6374(00)00247-5
   Ivanov II, 2008, CELL HOST MICROBE, V4, P337, DOI 10.1016/j.chom.2008.09.009
   Iyer A, 2010, NAT REV ENDOCRINOL, V6, P71, DOI 10.1038/nrendo.2009.264
   Jiang J, 2003, J IMMUNOL, V171, P3353, DOI 10.4049/jimmunol.171.7.3353
   Jogie-Brahim S, 2009, ENDOCR REV, V30, P417, DOI 10.1210/er.2008-0028
   Kaeberlein M, 2005, SCIENCE, V310, P1193, DOI 10.1126/science.1115535
   Kapasi ZF, 2002, EUR J IMMUNOL, V32, P1567, DOI 10.1002/1521-4141(200206)32:6<1567::AID-IMMU1567>3.0.CO;2-P
   Lawler DF, 2008, BRIT J NUTR, V99, P793, DOI 10.1017/S0007114507871686
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Lumeng CN, 2009, NAT MED, V15, P846, DOI 10.1038/nm0809-846
   Luo X, 2007, EMBO J, V26, P380, DOI 10.1038/sj.emboj.7601484
   Madsen MA, 2004, BIOCHEM BIOPH RES CO, V318, P998, DOI 10.1016/j.bbrc.2004.04.126
   Marinkovic D, 2007, J CLIN INVEST, V117, P2133, DOI 10.1172/JCI31807
   Nguyen TV, 2007, J EXP MED, V204, P1453, DOI 10.1084/jem.20062453
   Nijhuis J, 2009, OBESITY, V17, P2014, DOI 10.1038/oby.2009.113
   Ohkusu-Tsukada K, 1999, J IMMUNOL, V163, P1966
   Pawelec G, 1999, EXP GERONTOL, V34, P419, DOI 10.1016/S0531-5565(99)00002-9
   PELLEYMOUNTER MA, 1995, SCIENCE, V269, P540, DOI 10.1126/science.7624776
   Sepe A., 2010, GERONTOLOGY
   Shoelson SE, 2007, GASTROENTEROLOGY, V132, P2169, DOI 10.1053/j.gastro.2007.03.059
   STENHOLM S, 2009, CLIN ENDOCRINOL OXF
   Sutherland JP, 2004, METAB SYNDR RELAT D, V2, P82, DOI 10.1089/met.2004.2.82
   Tartaglia LA, 1995, CELL, V83, P1263, DOI 10.1016/0092-8674(95)90151-5
   Torres M, 2003, FRONT BIOSCI, V8, pD369, DOI 10.2741/999
   Tsukamoto H, 2009, P NATL ACAD SCI USA, V106, P18333, DOI 10.1073/pnas.0910139106
   Tyner SD, 2002, NATURE, V415, P45, DOI 10.1038/415045a
   Unger RH, 2003, ENDOCRINOLOGY, V144, P5159, DOI 10.1210/en.2003-0870
   Vallejo AN, 1998, J BIOL CHEM, V273, P8119, DOI 10.1074/jbc.273.14.8119
   Vijay-Kumar M, 2010, SCIENCE, V328, P228, DOI 10.1126/science.1179721
   Weyand CM, 2009, NAT REV RHEUMATOL, V5, P583, DOI 10.1038/nrrheum.2009.180
   Williams RS, 2008, CELL, V135, P97, DOI 10.1016/j.cell.2008.08.017
   ZHANG YY, 1994, NATURE, V372, P425, DOI 10.1038/372425a0
   Zhou BHP, 2001, NAT CELL BIOL, V3, P973, DOI 10.1038/ncb1101-973
   ZHOU T, 1995, J EXP MED, V182, P129, DOI 10.1084/jem.182.1.129
NR 58
TC 13
Z9 15
U1 0
U2 5
PU CURRENT BIOLOGY LTD
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0952-7915
EI 1879-0372
J9 CURR OPIN IMMUNOL
JI Curr. Opin. Immunol.
PD AUG
PY 2010
VL 22
IS 4
BP 541
EP 548
DI 10.1016/j.coi.2010.05.002
PG 8
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 645MH
UT WOS:000281462800019
PM 20591642
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Li, N
   Gao, YY
   Zhao, XC
   Wang, L
   Wang, R
   Song, M
   Hu, PH
   Lu, WT
   Zhao, TY
   Huang, FF
   Liu, BF
   Ren, RJ
   Wang, XY
AF Li, Na
   Gao, Yuanyuan
   Zhao, Xiaochuan
   Wang, Lan
   Wang, Ran
   Song, Mei
   Hu, Peihua
   Lu, Wenting
   Zhao, Tianyu
   Huang, Fanfan
   Liu, Bufan
   Ren, Ruojia
   Wang, Xueyi
TI Effects of multiple stress events at different stages of life on the
   incidence of metabolic syndrome
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE multiple stress; metabolic syndrome; fetal; childhood; adulthood
ID PHYSICAL HEALTH; PREVALENCE; TRENDS; ABUSE; CHINA; RISK
AB Objective: To investigate the effects of multiple stress events in different stages of life on the incidence of metabolic syndrome (MetS). Methods: Miners from Tangshan, China, were recruited for this study. Workers of the Kailuan Mining Group were evaluated to investigate whether exposure to Tangshan earthquakes during the fetal period in 1976. Adult life events and childhood trauma were assessed separately via the Life Event Scale and Childhood Trauma Questionnaire. The subjects were physically examined and general demographic data such as waist circumference were collected. Blood samples were collected for measurement of metabolic parameters. Corticotropin releasing hormone(CRH) levels was measured by enzyme-linked immunosorbent assay (ELISA). The subjects were divided into four groups according to their exposure to traumatic events in different stages of life: no exposure group, 1-exposure group, 2-exposures group, and 3-exposures group. The incidence of MetS, metabolic parameters and CRH levels in each of the four groups was compared. Results: In all, 626 people were enrolled; of these, 183, 262, 150, and 31 were in the no exposure, 1-exposure, 2-exposures, and 3-exposure groups, respectively. A remarkable variation in the incidence of MetS was observed among the four groups (x(2) = 16.462, P<0.001). MetS incidence increased with the increasing number of traumatic events, except for in the no exposure group (17.9% in 1-exposure group, 24.7% in 2-exposure group, and 48.4% in the 3-exposure group). Multivariate logistic regression analysis showed that exposure to multiple stress during the fetal, childhood, and adult stages of life represent independent risk factors for developing MetS (OR=3.134, 95%CI=1.042-9.429). Smoking increased the risk of developing MetS (OR=1.809, 95%CI=1.140-2.871). Conclusions: Exposure to multiple traumatic events in distinct life stages increases the risk of developing MetS. Smoking is a risk factor for developing MetS.
C1 [Li, Na; Gao, Yuanyuan; Zhao, Xiaochuan; Wang, Lan; Wang, Ran; Song, Mei; Hu, Peihua; Lu, Wenting; Zhao, Tianyu; Huang, Fanfan; Liu, Bufan; Ren, Ruojia; Wang, Xueyi] Hebei Med Univ, Hosp 1, Dept Psychiat, Shijiazhuang, Peoples R China.
   [Li, Na; Gao, Yuanyuan; Zhao, Xiaochuan; Wang, Lan; Wang, Ran; Song, Mei; Hu, Peihua; Lu, Wenting; Zhao, Tianyu; Huang, Fanfan; Liu, Bufan; Ren, Ruojia; Wang, Xueyi] Hebei Med Univ, Mental Hlth Ctr, Shijiazhuang, Peoples R China.
C3 Hebei Medical University; Hebei Medical University
RP Wang, XY (corresponding author), Hebei Med Univ, Hosp 1, Dept Psychiat, Shijiazhuang, Peoples R China.; Wang, XY (corresponding author), Hebei Med Univ, Mental Hlth Ctr, Shijiazhuang, Peoples R China.
EM ydyywxy@163.com
RI han, wei/ABG-2691-2021; Wang, Ran/GRX-9114-2022; Gao,
   Yuanyuan/LXB-0646-2024
FU Provincial Science and Technology Program of Hebei Province [21377711D];
   Hebei Medical University Clinical Research Innovation Team
   [2022LCTD-A1]; Introduce Foreign Intellectual Projects of Finance
   Department in Hebei Province [YZ202306]; Medical Research Projects from
   Health Commission of Hebei Province [20210418]; Clinical medicine
   excellent talents training project of Hebei Province
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This study was
   supported by Provincial Science and Technology Program of Hebei Province
   (21377711D), Hebei Medical University Clinical Research Innovation Team
   (2022LCTD-A1) and Introduce Foreign Intellectual Projects of Finance
   Department in Hebei Province (YZ202306). Medical Research Projects from
   Health Commission of Hebei Province (20210418). The government funded
   clinical medicine excellent talents training project of Hebei Province
   (No.ZF2023021).
CR Afifi TO, 2016, HEALTH REP, V27, P10
   Anni NS, 2021, EPIDEMIOL HEALTH, V43, DOI 10.4178/epih.e2021042
   Balaji S, 2023, AUSTRALAS PSYCHIATRY, V31, P381, DOI 10.1177/10398562231167782
   Bennett JE, 2018, LANCET, V392, P1072, DOI 10.1016/S0140-6736(18)31992-5
   Bruehl H, 2007, J CLIN ENDOCR METAB, V92, P2439, DOI 10.1210/jc.2006-2540
   Bunea IM, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/s41398-017-0032-3
   Burgueño AL, 2020, PSYCHONEUROENDOCRINO, V113, DOI 10.1016/j.psyneuen.2019.104560
   Cho SH, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-07626-1
   Deer LK, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1111474
   Delpierre C, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-3484-0
   Gardner R, 2019, PEDIATR RES, V86, P522, DOI 10.1038/s41390-019-0414-8
   Hackett RA, 2014, J CLIN ENDOCR METAB, V99, P4625, DOI 10.1210/jc.2014-2459
   He JY, 2019, CHILD ABUSE NEGLECT, V91, P102, DOI 10.1016/j.chiabu.2019.03.009
   He YN, 2019, ASIA PAC J CLIN NUTR, V28, P621, DOI 10.6133/apjcn.201909_28(3).0023
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Hostinar CE, 2017, PSYCHOSOM MED, V79, P514, DOI 10.1097/PSY.0000000000000455
   Hsu CN, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222111872
   Huang ZG, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.857985
   Klinger-König J, 2024, DTSCH ARZTEBL INT, V121, DOI 10.3238/arztebl.m2023.0225
   Leachman JR, 2022, BIOL SEX DIFFER, V13, DOI 10.1186/s13293-022-00439-x
   Lee LO, 2023, HEALTH PSYCHOL, V42, P172, DOI 10.1037/hea0001276
   Li N, 2020, J CLIN HYPERTENS, V22, P2354, DOI 10.1111/jch.14083
   Lu JL, 2017, J CLIN ENDOCR METAB, V102, P507, DOI 10.1210/jc.2016-2477
   McEwen BS, 2018, FRONT NEUROENDOCRIN, V49, P8, DOI 10.1016/j.yfrne.2017.11.001
   McEwen BS, 2000, NEUROPSYCHOPHARMACOL, V22, P108, DOI 10.1016/S0893-133X(99)00129-3
   MingYuan Z., 1987, Chin J Nervous Ment Dis, V2), P70
   Misiak B, 2020, J CLIN MED, V9, DOI 10.3390/jcm9123822
   Niu MY, 2023, J TRANSL MED, V21, DOI 10.1186/s12967-023-04062-1
   O'Connor DB, 2021, ANNU REV PSYCHOL, V72, P663, DOI 10.1146/annurev-psych-062520-122331
   Park EJ, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19094949
   Perrelli M, 2024, BIOMEDICINES, V12, DOI 10.3390/biomedicines12061187
   Rutters F, 2015, STRESS, V18, P507, DOI 10.3109/10253890.2015.1064891
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sanderson M, 2021, J HEALTH CARE POOR U, V32, P1384, DOI 10.1353/hpu.2021.0139
   Schulz LC, 2010, P NATL ACAD SCI USA, V107, P16757, DOI 10.1073/pnas.1012911107
   Shrestha RM, 2023, PLOS ONE, V18, DOI 10.1371/journal.pone.0282731
   Suglia SF, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-1149
   Thomas ML, 2018, CANCERS, V10, DOI 10.3390/cancers10040101
   Walker EA, 1999, ARCH GEN PSYCHIAT, V56, P609, DOI 10.1001/archpsyc.56.7.609
   Widom CS, 2012, AM J PUBLIC HEALTH, V102, P1135, DOI 10.2105/AJPH.2011.300636
   Wildenberg KS, 2023, PSYCHOSOM MED, V85, P498, DOI 10.1097/PSY.0000000000001213
   Yao F, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124475
   Zhang Mingyuan HY., 2015, Modern Psychiatry Series Psychiatric Rating Scale Manual
NR 43
TC 0
Z9 0
U1 1
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD OCT 22
PY 2024
VL 15
AR 1419443
DI 10.3389/fendo.2024.1419443
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA L0R1Z
UT WOS:001347872200001
PM 39502566
OA gold
DA 2025-06-11
ER

PT J
AU Helal, O
   Defoort, C
   Robert, S
   Marin, C
   Lesavre, N
   Lopez-Miranda, J
   Risérus, U
   Basu, S
   Lovegrove, J
   McMonagle, J
   Roche, HM
   Dignat-George, F
   Lairon, D
AF Helal, O.
   Defoort, C.
   Robert, S.
   Marin, C.
   Lesavre, N.
   Lopez-Miranda, J.
   Riserus, U.
   Basu, S.
   Lovegrove, J.
   McMonagle, J.
   Roche, H. M.
   Dignat-George, F.
   Lairon, D.
TI Increased levels of microparticles originating from endothelial cells,
   platelets and erythrocytes in subjects with metabolic syndrome:
   Relationship with oxidative stress
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Platelets microparticles; Endothelial microparticles; Erythrocytes
   microparticles; Metabolic syndrome; Glutathione peroxydase;
   8-Iso-prostaglandin F(2) alpha
ID CIRCULATING MICROPARTICLES; CELLULAR MICROPARTICLES;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; ATHEROSCLEROSIS;
   HYPERTENSION; ACTIVATION; GENERATION; OBESITY; MARKER
AB Background and aims: The Metabolic Syndrome (MetS) is associated with increased cardiovascular risk. Circulating microparticles (MP) are involved in the pathogenesis of atherothrombotic disorders and are raised in individual with CVD. We measured their level and cellular origin in subjects with MetS and analyzed their associations with 1/anthropometric and biological parameters of MetS, 2/inflammation and oxidative stress markers.
   Methods and results: Eighty-eight subjects with the MetS according to the NCEP-ATPIII definition were enrolled in a bicentric study and compared to 27 healthy controls. AnnexinV-positive MP (TMP), MP derived from platelets (PMP), erythrocytes (ErMP), endothelial cells (EMP), leukocytes (LMP) and granulocytes (PNMP) were determined by flow cytometry. MetS subjects had significantly higher counts/mu l of TMP (730.6 +/- 49.7 vs 352.8 +/- 35.6), PMP (416.0 +/- 43.8 vs 250.5 +/- 23.5), ErMP (243.8 +/- 22.1 vs 73.6 +/- 19.6) and EMP (7.8 +/- 0.8 vs 4.0 +/- 1.0) compared with controls. LMP and PNMP were not statistically different between groups. Multivariate analysis demonstrated that each criterion for the MetS influenced the number of TMP. Waist girth was a significant determinant of PMP and EMP level and blood pressure was correlated with EMP level. Glycemia positively correlated with PMP level whereas dyslipidemia influenced EMP and ErMP levels. Interestingly, the oxidative stress markers, plasma glutathione peroxy-dase and urinary 8-iso-prostaglandin F(2) alpha, independently influenced TMP and PMP levels whereas inflammatory markers did not, irrespective of MP type.
   Conclusion: Increased levels of TMP, PMP, ErMP and EMP are associated with individual metabolic abnormalities of MetS and oxidative stress. Whether MP assessment may represent a marker for risk stratification or a target for pharmacological intervention deserves further investigation. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Helal, O.; Defoort, C.; Lairon, D.] Univ Aix Marseille, Fac Med, UMR INSERM 476, INRA 1260, F-13385 Marseille 05, France.
   [Robert, S.; Dignat-George, F.] Univ Aix Marseille 2, Fac Pharm, CHU La Concept,Lab Immunol & Hematol, INSERM,UMR 608, Marseille, France.
   [Marin, C.; Lopez-Miranda, J.] Univ Cordoba, Hosp Univ Reina Sofia, Unidad Lipidos & Arteriosclerosis,Inst Salud Carl, CIBER Fisiopatol Obesidad & Nutr CB06 03, Cordoba, Spain.
   [Lesavre, N.] Assistance Publ Hop Marseille, CIC, F-13009 Marseille, France.
   [Riserus, U.] Uppsala Univ, Dept Publ Hlth & Caring Sci Clin Nutr & Metab, S-75185 Uppsala, Sweden.
   [Basu, S.] Univ Uppsala Hosp, Dept Publ Hlth & Caring Sci Oxidat Stress & Infla, S-75185 Uppsala, Sweden.
   [Basu, S.] Univ Uppsala Hosp, Ctr Excellence Inflammat, S-75185 Uppsala, Sweden.
   [Lovegrove, J.] Univ Reading, Sch Food & Nutr Sci, Reading RG6 6AP, Berks, England.
   [Lovegrove, J.] Univ Reading, Inst Cardiovasc & Metab Res, Reading RG6 6AP, Berks, England.
   [McMonagle, J.; Roche, H. M.] Univ Coll Dublin, Sch Publ Hlth & Populat Sci, UCD Conway Inst, Dublin 4, Ireland.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Aix-Marseille Universite; INRAE; Aix-Marseille Universite; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Assistance
   Publique-Hopitaux de Marseille; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; Hospital Universitario Reina Sofia -
   Cordoba; Universidad de Cordoba; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Aix-Marseille Universite; Assistance
   Publique-Hopitaux de Marseille; Uppsala University; Uppsala University;
   Uppsala University Hospital; Uppsala University; Uppsala University
   Hospital; University of Reading; University of Reading; University
   College Dublin
RP Defoort, C (corresponding author), Univ Aix Marseille, Fac Med, UMR INSERM 476, INRA 1260, 27 Bd Jean Moulin, F-13385 Marseille 05, France.
EM catherine.defoort@univmed.fr
RI Lovegrove, Julie/LRV-2592-2024; Lopez-Miranda, Jose/Y-8306-2019; Marin
   Hinojosa, Carmen/AFO-1294-2022; DIGNAT-GEORGE, Francoise/R-1129-2016
OI Roche, Helen/0000-0002-0628-3318; Lopez-Miranda,
   Jose/0000-0002-8844-0718; Lairon, Denis/0000-0001-9941-3742;
   DIGNAT-GEORGE, Francoise/0000-0001-7006-4462
FU European Commission [FOOD-CT-2003-505944]
FX This research was partly supported by funding from the European
   Commission, FP6 as part of the LIPGENE project (FOOD-CT-2003-505944).
CR Agouni A, 2008, AM J PATHOL, V173, P1210, DOI 10.2353/ajpath.2008.080228
   [Anonymous], JAMA
   Arteaga RB, 2006, AM J CARDIOL, V98, P70, DOI 10.1016/j.amjcard.2006.01.054
   Basu S, 1998, PROSTAG LEUKOTR ESS, V58, P319, DOI 10.1016/S0952-3278(98)90042-4
   Bernal-Mizrachi L, 2003, AM HEART J, V145, P962, DOI 10.1016/S0002-8703(03)00103-0
   Boulanger CM, 2006, HYPERTENSION, V48, P180, DOI 10.1161/01.HYP.0000231507.00962.b5
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Chironi G, 2006, ARTERIOSCL THROM VAS, V26, P2775, DOI 10.1161/01.ATV.0000249639.36915.04
   Chung SM, 2007, ARTERIOSCL THROM VAS, V27, P414, DOI 10.1161/01.ATV.0000252898.48084.6a
   Dalli J, 2008, BLOOD, V112, P2512, DOI 10.1182/blood-2008-02-140533
   Diamant M, 2002, CIRCULATION, V106, P2442, DOI 10.1161/01.CIR.0000036596.59665.C6
   Esposito K, 2006, ARTERIOSCL THROM VAS, V26, P1926, DOI 10.1161/01.ATV.0000231512.15115.25
   Ferreira AC, 2004, CIRCULATION, V110, P3599, DOI 10.1161/01.CIR.0000148820.55611.6B
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Jy W, 2004, J THROMB HAEMOST, V2, P1842, DOI 10.1111/j.1538-7836.2004.00936.x
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Montuschi P, 2004, FASEB J, V18, P1791, DOI 10.1096/fj.04-2330rev
   Morel O, 2003, J THROMB HAEMOST, V1, P171, DOI 10.1046/j.1538-7836.2003.00010.x
   Morel O, 2004, CURR OPIN HEMATOL, V11, P156, DOI 10.1097/01.moh.0000131441.10020.87
   Morel O, 2006, ARTERIOSCL THROM VAS, V26, P2594, DOI 10.1161/01.ATV.0000246775.14471.26
   Piccin A, 2007, BLOOD REV, V21, P157, DOI 10.1016/j.blre.2006.09.001
   Pirro M, 2008, ATHEROSCLEROSIS, V197, P757, DOI 10.1016/j.atherosclerosis.2007.07.012
   Pirro M, 2006, ARTERIOSCL THROM VAS, V26, P2530, DOI 10.1161/01.ATV.0000243941.72375.15
   Preston RA, 2003, HYPERTENSION, V41, P211, DOI 10.1161/01.HYP.0000049760.15764.2D
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Rudich A, 1998, DIABETES, V47, P1562, DOI 10.2337/diabetes.47.10.1562
   Sabatier F, 2002, DIABETES, V51, P2840, DOI 10.2337/diabetes.51.9.2840
   Suematsu M, 2002, MICROCIRCULATION, V9, P259, DOI 10.1038/sj.mn.7800141
   Ueba T, 2008, THROMB HAEMOSTASIS, V100, P280, DOI 10.1160/TH07-11-0668
   Wang JM, 2007, AM J HYPERTENS, V20, P957, DOI 10.1016/j.amjhyper.2007.04.005
   ZWAAL RFA, 1992, BIOCHIM BIOPHYS ACTA, V1180, P1, DOI 10.1016/0925-4439(92)90019-J
NR 32
TC 95
Z9 102
U1 0
U2 10
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD SEP
PY 2011
VL 21
IS 9
BP 665
EP 671
DI 10.1016/j.numecd.2010.01.004
PG 7
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 830CW
UT WOS:000295635700008
PM 20399083
DA 2025-06-11
ER

PT J
AU Miyagawa, R
   Asakura, T
   Nakamura, T
   Okada, H
   Iwaki, S
   Sobel, BE
   Fujii, S
AF Miyagawa, Ryu
   Asakura, Takefumi
   Nakamura, Tomomi
   Okada, Hiromi
   Iwaki, Soichiro
   Sobel, Burton E.
   Fujii, Satoshi
TI Increased expression of plasminogen activator inhibitor type-1 (PAI-1)
   in HEPG2 cells induced by insulin mediated by the 3′-untranslated region
   of the PAI-1 gene and its pharmacologic implications
SO CORONARY ARTERY DISEASE
LA English
DT Article
DE cardiovascular risk; insulin; liver; metabolic syndrome; oxidative
   stress; plasminogen activator inhibitor-1; statins; thrombosis
ID POSTTRANSCRIPTIONAL REGULATION; METABOLIC SYNDROME; MESSENGER-RNA;
   AUGMENTATION; PROMOTER; STATINS
AB Objective Insulin increases, through several molecular mechanisms, expression of plasminogen activator inhibitor-1 (PAI-1), the major physiologic inhibitor of fibrinolysis. This phenomenon has been implicated as a cause of accelerated coronary artery disease and the increased incidence of acute coronary syndromes associated with type 2 diabetes. We have previously reported that physiologic and pharmacologic concentrations of insulin induce PAI-1 synthesis in human HepG2 cells and that simvastatin can attenuate its effects. This study was performed to further elucidate mechanisms responsible for the insulin-induced PAI-1 production.
   Methods Concentrations of PAI-1 mRNA were determined by real-time PCR, and PAI-1 protein was assayed by western blotting. PAI-1 promoter (-829 to +36 bp) activity was assayed with the use of luciferase reporter assays. The potential role of the 30-untranslated region (UTR) in the PAI-1 gene was assayed with the use of luciferase constructs containing the 30-UTR. Oxidative stress was measured by loading cells with carboxy-2,7 dichlorodihydrofluorescein.
   Results Insulin increased PAI-1 promoter activity, PAI-1 mRNA, and accumulation of PAI-1 protein in the conditioned media. Insulin-inducible PAI-1 promoter activity was attenuated by simvastatin. Experiments performed with luciferase reporters containing the 3'-UTR showed that insulin increased luciferase activity through this region. Insulin also increased oxidative stress. Both insulin-inducible luciferase activity through the 3'-UTR and oxidative stress were attenuated by simvastatin.
   Conclusion Insulin can increase PAI-1 expression through multiple mechanisms including induction mediated by the 3'-UTR of the PAI-1 gene. Accordingly, beneficial pleiotropic effects of statins on coronary artery disease may be attributable, in part, to attenuation of overexpression of PAI-1 mediated by the 3'-UTR in syndromes of insulin resistance ( such as the metabolic syndrome) and type 2 diabetes. Coron Artery Dis 21: 144-150 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Fujii, Satoshi] Nagoya City Univ, Dept Mol & Cellular Pathobiol & Therapeut, Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan.
   [Sobel, Burton E.] Univ Vermont, Cardiovasc Res Inst, Colchester, VT USA.
C3 Nagoya City University; University of Vermont
RP Fujii, S (corresponding author), Nagoya City Univ, Dept Mol & Cellular Pathobiol & Therapeut, Sch Pharmaceut Sci, Mizuho Ku, Tanabe Dori 3-1, Nagoya, Aichi 4678603, Japan.
EM sfujii@phar.nagoya-cu.ac.jp
OI gong chuan, long/0009-0008-1975-938X
FU Ministry of Education, Science, Sport, and Culture of Japan
FX The authors thank Professor Shinichi Hoshino (Department of Biological
   Chemistry, Nagoya City University, Japan) for useful advice and helpful
   discussions, and Lorraine Dales for assistance in preparation of the
   manuscript. This work was supported in part by grants-in-aid for
   scientific research from the Ministry of Education, Science, Sport, and
   Culture of Japan.
CR Alessi MC, 2008, THROMB HAEMOSTASIS, V99, P995, DOI 10.1160/TH07-11-0682
   Alessi MC, 2006, ARTERIOSCL THROM VAS, V26, P2200, DOI 10.1161/01.ATV.0000242905.41404.68
   Biswas S, 2007, AM J PHYSIOL-HEART C, V292, pH758, DOI 10.1152/ajpheart.00718.2006
   BOSMA PJ, 1988, J BIOL CHEM, V263, P9129
   Delbosc S, 2002, J CARDIOVASC PHARM, V40, P611, DOI 10.1097/00005344-200210000-00015
   Dong J, 2005, ARTERIOSCL THROM VAS, V25, P1078, DOI 10.1161/01.ATV.0000159701.24372.49
   Duckworth W, 2009, NEW ENGL J MED, V360, P129, DOI 10.1056/NEJMoa0808431
   FATTAL PG, 1993, NUCLEIC ACIDS RES, V21, P1463, DOI 10.1093/nar/21.6.1463
   FATTAL PG, 1992, J BIOL CHEM, V267, P12412
   Gerstein HC, 2008, NEW ENGL J MED, V358, P2545, DOI 10.1056/NEJMoa0802743
   HAMSTEN A, 1985, NEW ENGL J MED, V313, P1557, DOI 10.1056/NEJM198512193132501
   Heaton JH, 2003, THROMB HAEMOSTASIS, V89, P959
   MCGILL JB, 1994, DIABETES, V43, P104, DOI 10.2337/diabetes.43.1.104
   Misquitta CM, 2001, MOL CELL BIOCHEM, V224, P53, DOI 10.1023/A:1011982932645
   Patel A, 2008, NEW ENGL J MED, V358, P2560, DOI 10.1056/NEJMoa0802987
   Pertseva MN, 2005, ANN NY ACAD SCI, V1040, P429, DOI 10.1196/annals.1327.081
   Sato Y, 2008, CORONARY ARTERY DIS, V19, P355, DOI 10.1097/MCA.0b013e328300dbe3
   Schneider DJ, 1996, CORONARY ARTERY DIS, V7, P813, DOI 10.1097/00019501-199611000-00004
   Schneider DJ, 2004, J HISTOCHEM CYTOCHEM, V52, P1091, DOI 10.1369/jhc.4a6260.2004
   SCHNEIDER DJ, 1992, DIABETES, V41, P890, DOI 10.2337/diabetes.41.7.890
   SCHNEIDER DJ, 1991, P NATL ACAD SCI USA, V88, P9959, DOI 10.1073/pnas.88.22.9959
   Sobel BE, 1999, CIRCULATION, V99, P2496, DOI 10.1161/01.CIR.99.19.2496
   Sobel BE, 2003, ARTERIOSCL THROM VAS, V23, P1979, DOI 10.1161/01.ATV.0000091250.53231.4D
   Sobel BE, 2006, BIOCHEM BIOPH RES CO, V346, P102, DOI 10.1016/j.bbrc.2006.05.078
   Tawfik HE, 2006, J PHARMACOL EXP THER, V319, P386, DOI 10.1124/jpet.106.106823
   Vulin AI, 2004, J BIOL CHEM, V279, P25172, DOI 10.1074/jbc.M403184200
   Zaman AKMT, 2009, EXP BIOL MED, V234, P246, DOI 10.3181/0811-RM-321
NR 27
TC 11
Z9 13
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0954-6928
EI 1473-5830
J9 CORONARY ARTERY DIS
JI Coronary Artery Dis.
PD MAY
PY 2010
VL 21
IS 3
BP 144
EP 150
DI 10.1097/MCA.0b013e328335790e
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 622ML
UT WOS:000279667800003
PM 20299979
DA 2025-06-11
ER

PT J
AU Klisic, A
   Kavaric, N
   Ninic, A
AF Klisic, A.
   Kavaric, N.
   Ninic, A.
TI Serum cystatin C levels are associated with triglycerides/high-density
   lipoprotein cholesterol ratio in adolescent girls ages between 16-19
   years old
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Cystatin C; Cardiometabolic risk; Dyslipidemia; Inflammation
ID METABOLIC SYNDROME; OXIDATIVE STRESS; MARKERS; PREDICT; INDEX
AB OBJECTIVE: The pathophysiological role of cystatin C in cardiometabolic disorders is not completely explored in young population. On the other hand, together with the increase in obesity, dyslipidemia and insulin resistance (IR) are often observed even in youngsters. The aim of the study was to investigate the relationship between cystatin C and triglycerides-to-high-density lipoprotein cholesterol ratio (TG/HDL-c). as an indicator of dyslipidemia and a surrogate marker of IR in the cohort of adolescent girls ages between 16-19 years.
   PATIENTS AND METHODS: A total of 99 girls were included in the study. Anthropometric and biochemical parameters were provided. Associations of biochemical markers with TG/HDL-c ratio were tested using univariable and multivariable ordinal regression analysis for TG/HDL-c ratio tertiles as dependent variable.
   RESULTS: In univariate analysis, cystatin C levels were significantly associated with TG/HDL-c ratio (OR=1.813; 95% Cl: 1.190-2.757, p=0.005). Furthermore, multivariate analysis revealed that cystatin C was an independent predictor of TG/HDL-c ratio when body mass index and high sensitivity C-reactive protein (i.e., markers that were significantly correlated with TG/HDL-c ratio in Spearman's correlation analysis) were included in the Model. Adjusted odds for cystatin C (OR=1.621; 95% CI: 1.028-2.552, p=0.037) demonstrated that rise in cystatin C by 0.1 mg/L increased the probability for higher TG/HDL-c tertile group by 1.621 times.
   CONCLUSIONS: Serum cystatin C levels are associated with TG/HDL-c ratio in adolescent girls. Longitudinal studies are needed to confirm the causal relationship between cystatin C and TG/HDL-c ratio and to further explore its diagnostic and therapeutic potential in dyslipidemia and insulin resistance in young population.
C1 [Klisic, A.; Kavaric, N.] Univ Montenegro, Primary Hlth Care Ctr, Fac Med, Podgorica, Montenegro.
   [Ninic, A.] Univ Belgrade, Fac Pharm, Dept Med Biochem, Belgrade, Serbia.
C3 University of Montenegro; University of Belgrade
RP Klisic, A (corresponding author), Univ Montenegro, Primary Hlth Care Ctr, Fac Med, Podgorica, Montenegro.
EM aleksandranklisic@gmail.com
RI Klisic, Aleksandra/ABC-9219-2020
OI Klisic, Aleksandra/0000-0001-7870-0996
FU Ministry of Science, Montenegro; Ministry of Education, Science and
   Technological Development, Republic of Serbia [451-03-68/2020-14/200161]
FX This work was financially supported in part by a grant from the Ministry
   of Science, Montenegro and the Ministry of Education, Science and
   Technological Development, Republic of Serbia (project number
   451-03-68/2020-14/200161).
CR Al-Batsh MMW, 2018, HORM MOL BIOL CLIN I, V36, DOI 10.1515/hmbci-2018-0058
   Ates E, 2019, J MED BIOCHEM, V38, P445, DOI 10.2478/jomb-2019-0015
   Behiry EG, 2019, ENDOCR METAB IMMUNE, V19, P676, DOI 10.2174/1871530319666190121123535
   Biyik Z, 2019, EUR REV MED PHARMACO, V23, P2167, DOI 10.26355/eurrev_201903_17262
   Chen HY, 2019, EUR REV MED PHARMACO, V23, P4391, DOI 10.26355/eurrev_201905_17946
   Codoñer-Franch P, 2011, PEDIATR NEPHROL, V26, P301, DOI 10.1007/s00467-010-1679-7
   Colak E, 2021, J MED BIOCHEM, V40, P1, DOI 10.5937/jomb0-24652
   Colak E, 2020, J MED BIOCHEM, V39, P346, DOI 10.2478/jomb-2019-0051
   Correia-Costa L, 2015, PEDIATR RES, V78, P436, DOI 10.1038/pr.2015.130
   da Luz PL, 2008, CLINICS, V63, P427, DOI 10.1590/S1807-59322008000400003
   Giannini C, 2011, DIABETES CARE, V34, P1869, DOI 10.2337/dc10-2234
   Gualtieri P, 2020, EUR REV MED PHARMACO, V24, P5199, DOI 10.26355/eurrev_202005_21300
   Harada M, 2017, J CARDIOL, V69, P222, DOI 10.1016/j.jjcc.2016.03.013
   Juhas I, 2020, J MED BIOCHEM, V39, P40, DOI 10.2478/jomb-2019-0006
   Klisic A, 2020, PREVENTIVNA PEDIJATR, V6, P71
   Klisic A, 2020, EAT WEIGHT DISORD-ST, V25, P9, DOI 10.1007/s40519-018-0490-5
   Klisic A, 2019, J LAB MED, V43, P29, DOI 10.1515/labmed-2018-0325
   Klisic A, 2017, ARCH MED SCI, V13, P1188, DOI 10.5114/aoms.2017.68972
   Klisic A, 2016, J MED BIOCHEM, V35, P282, DOI 10.1515/jomb-2016-0005
   Krawczyk M, 2018, ACTA BIOCHIM POL, V65, P605, DOI 10.18388/abp.2018_2649
   Laarman MD, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.118.011201
   Liu DC, 2020, HYPERTENS RES, V43, P948, DOI 10.1038/s41440-020-0439-8
   Magnusson M, 2013, J INTERN MED, V274, P192, DOI 10.1111/joim.12051
   Maksimovic M, 2020, J MED BIOCHEM, V39, P215, DOI 10.2478/jomb-2019-0027
   Medeiros T, 2017, DIAB MET SYND CLIN R, V11, pS351, DOI 10.1016/j.dsx.2017.03.015
   Mirjanic-Azaric B, 2019, J MED BIOCHEM, V38, P268, DOI 10.2478/jomb-2018-0039
   Naour N, 2009, OBESITY, V17, P2121, DOI 10.1038/oby.2009.96
   Nedeljkovic BB, 2019, J MED BIOCHEM, V38, P53, DOI 10.2478/jomb-2018-0011
   Nelson MC, 2008, OBESITY, V16, P2205, DOI 10.1038/oby.2008.365
   Ninic A, 2020, ARCH MED SCI, V16, P42
   Olson K, 2012, CHOLESTEROL, DOI 10.1155/2012/794252
   Redon J, 2015, CURR HYPERTENS REP, V17, DOI 10.1007/s11906-015-0555-z
   Salman DÖ, 2019, J CLIN RES PEDIATR E, V11, P46, DOI 10.4274/jcrpe.galenos.2018.2018.0046
   Sayin S, 2020, J MED BIOCHEM, V39, P25, DOI 10.2478/jomb-2019-0009
   Wang YS, 2019, ARCH MED SCI, V15, P1203, DOI 10.5114/aoms.2018.79565
   Zanza C, 2019, EUR REV MED PHARMACO, V23, P7703, DOI 10.26355/eurrev_201909_18894
NR 36
TC 16
Z9 16
U1 0
U2 1
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PY 2020
VL 24
IS 20
BP 10680
EP 10686
DI 10.26355/eurrev_202010_23426
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA OL1FI
UT WOS:000585086700053
PM 33155226
DA 2025-06-11
ER

PT J
AU Kochi, T
   Shimizu, M
   Ohno, T
   Baba, A
   Sumi, T
   Kubota, M
   Shirakami, Y
   Tsurumi, H
   Tanaka, T
   Moriwaki, H
AF Kochi, Takahiro
   Shimizu, Masahito
   Ohno, Tomohiko
   Baba, Atsushi
   Sumi, Takafumi
   Kubota, Masaya
   Shirakami, Yohei
   Tsurumi, Hisashi
   Tanaka, Takuji
   Moriwaki, Hisataka
TI Preventive effects of the angiotensin-converting enzyme inhibitor,
   captopril, on the development of azoxymethane-induced colonic
   preneoplastic lesions in diabetic and hypertensive rats
SO ONCOLOGY LETTERS
LA English
DT Article
DE metabolic syndrome; colon carcinogenesis; hypertension;
   angiotensin-converting enzyme inhibitor; renin-angiotensin system
ID C57BL/KSJ-DB/DB OBESE MICE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   CANCER; SYSTEM; CARCINOGENESIS; MORTALITY; RECEPTOR; MODEL; RISK
AB Metabolic syndrome (Mets), including diabetes and hypertension, increases the risk of colorectal cancer via the induction of chronic inflammation, acceleration of oxidative stress, and activation of the renin-angiotensin system. The present study examined the possible inhibitory effects of captopril, an angiotensin-converting enzyme (ACE) inhibitor and anti hypertensive drug, on the development of azoxymethane (AOM)-induced colonic premalignant lesions, aberrant crypt foci (ACF), in SHRSP.Z-Lepr(fa)/IzmDmcr (SHRSP-ZF) diabetic and hypertensive rats. Male 6-week-old SHRSP-ZF rats were administered two, weekly intraperitoneal injections of AOM (20 mg/kg body weight). Following the second injection, the rats received drinking water containing captopril (8 mg/kg/day) for two weeks. At sacrifice, captopril administration significantly lowered the blood pressure and reduced the total number and size of ACF compared with those observed in the untreated group. The serum levels of angiotensin-II and the expression levels of ACE and angiotensin-II type 1 receptor mRNA on the colonic mucosa decreased following captopril treatment. Captopril also reduced the urinary 8-hydroxy-2'-deoxyguanosine levels and the serum derivatives of reactive oxygen metabolites levels, both of which are oxidative stress markers, but increased the mRNA levels of catalase, an antioxidant enzyme, in the colonic epithelium. Moreover, the expression levels of tumor necrosis factor-alpha, interleukin-18, monocyte chemoattractant protein-1, inducible nitric oxide synthase, vascular endothelial growth factor and proliferating cell nuclear antigen mRNA in the colonic epithelium were decreased significantly following captopril administration. These observations suggested that captopril prevents the development of ACF by inhibiting renin-angiotensin system activation and attenuating inflammation and oxidative stress in SHRSP-ZF rats. Therefore, targeting Mets-related pathophysiological conditions, including renin-angiotensin system activation, may be an effective strategy to prevent colorectal carcinogenesis in patients with Mets, particularly those with hypertension.
C1 [Kochi, Takahiro; Shimizu, Masahito; Ohno, Tomohiko; Baba, Atsushi; Sumi, Takafumi; Kubota, Masaya; Shirakami, Yohei; Tsurumi, Hisashi; Moriwaki, Hisataka] Gifu Univ, Dept Med Gastroenterol, Grad Sch Med, Gifu, Chubu 5011194, Japan.
   [Tanaka, Takuji] Gifu Univ, Dept Tumor Pathol, Grad Sch Med, Gifu, Chubu 5011194, Japan.
C3 Gifu University; Gifu University
RP Shimizu, M (corresponding author), Gifu Univ, Dept Med Gastroenterol, Grad Sch Med, 1-1 Yanagido, Gifu, Chubu 5011194, Japan.
EM shimim-gif@umin.ac.jp
CR Ager EI, 2008, CARCINOGENESIS, V29, P1675, DOI 10.1093/carcin/bgn171
   Ahmed RL, 2006, CANCER-AM CANCER SOC, V107, P28, DOI 10.1002/cncr.21950
   Bernardi S, 2012, J RENIN-ANGIO-ALDO S, V13, P202, DOI 10.1177/1470320311426023
   Cassis P, 2010, PFLUG ARCH EUR J PHY, V459, P325, DOI 10.1007/s00424-009-0725-4
   Chen H, 2003, AM J PHYSIOL-ENDOC M, V284, pE804, DOI 10.1152/ajpendo.00330.2002
   Chrysant SG, 2010, CURR CLIN PHARMACOL, V5, P89, DOI 10.2174/157488410791110742
   de Kloet AD, 2010, PHYSIOL BEHAV, V100, P525, DOI 10.1016/j.physbeh.2010.03.018
   Deshayes F, 2005, TRENDS ENDOCRIN MET, V16, P293, DOI 10.1016/j.tem.2005.07.009
   Donohoe CL, 2010, BRIT J SURG, V97, P628, DOI 10.1002/bjs.7079
   Fox KM, 2003, LANCET, V362, P782
   Fyhrquist F, 2008, J INTERN MED, V264, P224, DOI 10.1111/j.1365-2796.2008.01981.x
   George AJ, 2010, NAT REV CANCER, V10, P745, DOI 10.1038/nrc2945
   Hiraoka-Yamamoto J, 2004, CLIN EXP PHARMACOL P, V31, P107, DOI 10.1111/j.1440-1681.2004.04121.x
   Ishino K, 2012, CANC LETT
   Kedika R, 2011, J CLIN GASTROENTEROL, V45, pE12, DOI 10.1097/MCG.0b013e3181ea1044
   Kochi T, 2013, INT J MOL SCI, V14, P14700, DOI 10.3390/ijms140714700
   Kubota M, 2012, NUTR CANCER, V64, P72, DOI 10.1080/01635581.2012.630554
   Kubota M, 2011, BIOCHEM BIOPH RES CO, V410, P108, DOI 10.1016/j.bbrc.2011.05.115
   Ogawa K, 2012, CANCER SCI, V103, P951, DOI 10.1111/j.1349-7006.2012.02237.x
   Shimizu M, 2012, INT J MOL SCI, V13, P579, DOI 10.3390/ijms13010579
   Shimizu M, 2009, CLIN CANCER RES, V15, P3068, DOI 10.1158/1078-0432.CCR-08-2093
   Shimizu M, 2008, CANCER PREV RES, V1, P298, DOI 10.1158/1940-6207.CAPR-08-0045
   Shimomoto T, 2012, CLIN EXP METASTAS, V29, P915, DOI 10.1007/s10585-012-9480-6
   Smith Gary Robert, 2004, J Inflamm (Lond), V1, P3, DOI 10.1186/1476-9255-1-3
   Stocks T, 2012, HYPERTENSION, V59, P802, DOI 10.1161/HYPERTENSIONAHA.111.189258
   Suzuki Y., 2013, J CANC RES IN PRESS
   Tamarat R, 2002, LAB INVEST, V82, P747, DOI 10.1097/01.LAB.0000017372.76297.EB
   Tudek B, 2012, MUTAT RES-FUND MOL M, V736, P82, DOI 10.1016/j.mrfmmm.2012.04.003
   Uemura H, 2008, MOL CANCER RES, V6, P250, DOI 10.1158/1541-7786.MCR-07-0289
   Ueno T, 2008, HYPERTENS RES, V31, P1021, DOI 10.1291/hypres.31.1021
   Valavanidis A, 2009, J ENVIRON SCI HEAL C, V27, P120, DOI 10.1080/10590500902885684
   van Vark LC, 2012, EUR HEART J, V33, P2088, DOI 10.1093/eurheartj/ehs075
   Yasuda Y, 2010, CANCER SCI, V101, P1701, DOI 10.1111/j.1349-7006.2010.01579.x
   Yvan-Charvet L, 2009, ENDOCRINOLOGY, V150, P1421, DOI 10.1210/en.2008-1120
NR 34
TC 14
Z9 14
U1 0
U2 5
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-1074
EI 1792-1082
J9 ONCOL LETT
JI Oncol. Lett.
PD JUL
PY 2014
VL 8
IS 1
BP 223
EP 229
DI 10.3892/ol.2014.2136
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA AK1ML
UT WOS:000338179100041
PM 24959250
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Denimal, D
   Monier, S
   Bouillet, B
   Vergés, B
   Duvillard, L
AF Denimal, Damien
   Monier, Serge
   Bouillet, Benjamin
   Verges, Bruno
   Duvillard, Laurence
TI High-Density Lipoprotein Alterations in Type 2 Diabetes and Obesity
SO METABOLITES
LA English
DT Review
DE high-density lipoprotein; type 2 diabetes; obesity; metabolic syndrome;
   cholesterol efflux; glycoxidation; endothelium
ID APOLIPOPROTEIN-A-I; CHOLESTEROL EFFLUX CAPACITY;
   CORONARY-ARTERY-DISEASE; ELEVATED OXIDATIVE STRESS;
   NUCLEAR-MAGNETIC-RESONANCE; PRE-BETA-HDL; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; PARTICLE-SIZE; ADVANCED GLYCATION
AB Alterations affecting high-density lipoproteins (HDLs) are one of the various abnormalities observed in dyslipidemia in type 2 diabetes mellitus (T2DM) and obesity. Kinetic studies have demonstrated that the catabolism of HDL particles is accelerated. Both the size and the lipidome and proteome of HDL particles are significantly modified, which likely contributes to some of the functional defects of HDLs. Studies on cholesterol efflux capacity have yielded heterogeneous results, ranging from a defect to an improvement. Several studies indicate that HDLs are less able to inhibit the nuclear factor kappa-B (NF-kappa B) proinflammatory pathway, and subsequently, the adhesion of monocytes on endothelium and their recruitment into the subendothelial space. In addition, the antioxidative function of HDL particles is diminished, thus facilitating the deleterious effects of oxidized low-density lipoproteins on vasculature. Lastly, the HDL-induced activation of endothelial nitric oxide synthase is less effective in T2DM and metabolic syndrome, contributing to several HDL functional defects, such as an impaired capacity to promote vasodilatation and endothelium repair, and difficulty counteracting the production of reactive oxygen species and inflammation.
C1 [Denimal, Damien; Monier, Serge; Bouillet, Benjamin; Verges, Bruno; Duvillard, Laurence] Univ Burgundy, INSERM, UMR1231, F-21000 Dijon, France.
   [Denimal, Damien; Duvillard, Laurence] CHU Dijon Bourgogne, Dept Biochem, F-21000 Dijon, France.
   [Bouillet, Benjamin; Verges, Bruno] CHU Dijon Bourgogne, Dept Endocrinol & Diabetol, F-21000 Dijon, France.
C3 Institut Agro; AgroSup Dijon; Universite Bourgogne Europe; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite
   Bourgogne Europe; CHU Dijon Bourgogne; Universite Bourgogne Europe; CHU
   Dijon Bourgogne
RP Denimal, D (corresponding author), Univ Burgundy, INSERM, UMR1231, F-21000 Dijon, France.; Denimal, D (corresponding author), CHU Dijon Bourgogne, Dept Biochem, F-21000 Dijon, France.
EM damien.denimal@u-bourgogne.fr
RI Bouillet, Benjamin/AAG-8165-2019
OI DENIMAL, Damien/0000-0001-5454-954X; BOUILLET,
   Benjamin/0000-0002-4317-6714
CR Abbasi A, 2013, J CLIN ENDOCR METAB, V98, pE1352, DOI 10.1210/jc.2013-1680
   Adam S, 2022, J CLIN ENDOCR METAB, V107, P2182, DOI 10.1210/clinem/dgac244
   Agarwala AP, 2015, ARTERIOSCL THROM VAS, V35, P1515, DOI 10.1161/ATVBAHA.115.305504
   Alenezi MY, 2004, J CLIN ENDOCR METAB, V89, P761, DOI 10.1210/jc.2003-031213
   Annema W, 2016, SCI REP-UK, V6, DOI 10.1038/srep27367
   Annema W, 2010, J LIPID RES, V51, P743, DOI 10.1194/jlr.M000323
   Apro J, 2016, ARTERIOSCL THROM VAS, V36, P787, DOI 10.1161/ATVBAHA.116.307385
   Aroor AR, 2014, DIABETES, V63, P2216, DOI 10.2337/db14-0424
   Assinger A, 2010, ATHEROSCLEROSIS, V212, P153, DOI 10.1016/j.atherosclerosis.2010.05.010
   Bacchetti T, 2014, METABOLISM, V63, P307, DOI 10.1016/j.metabol.2013.10.013
   Badellino KO, 2006, PLOS MED, V3, P245, DOI 10.1371/journal.pmed.0030022
   Barberio MD, 2019, J TRANSL MED, V17, DOI 10.1186/s12967-019-1980-6
   Besler C, 2011, J CLIN INVEST, V121, P2693, DOI 10.1172/JCI42946
   Bonilha I, 2021, METABOLITES, V11, DOI 10.3390/metabo11120807
   Bouillet B, 2014, DIABETES CARE, V37, P1148, DOI 10.2337/dc13-1467
   Brindisi MC, 2013, DIABETES-METAB RES, V29, P618, DOI 10.1002/dmrr.2434
   Brites F, 2017, BBA CLIN, V8, P66, DOI 10.1016/j.bbacli.2017.07.002
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Cardner M, 2020, JCI INSIGHT, V5, DOI 10.1172/jci.insight.131491
   CAVALLERO E, 1995, ARTERIOSCL THROM VAS, V15, P2130, DOI 10.1161/01.ATV.15.12.2130
   Chan DC, 2006, AM J CLIN NUTR, V84, P37, DOI 10.1093/ajcn/84.1.37
   Chan DC, 2009, J CLIN ENDOCR METAB, V94, P989, DOI 10.1210/jc.2008-1457
   Chen ZL, 2020, J TRANSL MED, V18, DOI 10.1186/s12967-020-02623-2
   Cheng AM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033917
   Cochran BJ, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10040850
   Curtiss LK, 2000, BIOCHEMISTRY-US, V39, P5712, DOI 10.1021/bi992902m
   Dangas K, 2022, EUR HEART J-CARD PHA, V8, P622, DOI 10.1093/ehjcvp/pvac025
   Davidson WS, 2017, J LIPID RES, V58, P1916, DOI 10.1194/jlr.M078667
   de Souza JA, 2008, ATHEROSCLEROSIS, V197, P84, DOI 10.1016/j.atherosclerosis.2007.08.009
   de Vries R, 2008, ATHEROSCLEROSIS, V196, P733, DOI 10.1016/j.atherosclerosis.2006.12.027
   Denimal D, 2022, CARDIOVASC DIABETOL, V21, DOI 10.1186/s12933-022-01591-9
   Denimal D, 2022, J CLIN ENDOCR METAB, V107, pE3816, DOI 10.1210/clinem/dgac339
   Denimal D, 2017, ARTERIOSCL THROM VAS, V37, P804, DOI 10.1161/ATVBAHA.117.309287
   Denimal D, 2016, ATHEROSCLEROSIS, V246, P106, DOI 10.1016/j.atherosclerosis.2015.12.042
   diabetesatlas, IDF Diabetes Atlas
   Domingo-Espín J, 2018, BBA-MOL BASIS DIS, V1864, P2822, DOI 10.1016/j.bbadis.2018.05.014
   Dorcely Brenda, 2017, Diabetes Metab Syndr Obes, V10, P345, DOI 10.2147/DMSO.S100074
   Drew BG, 2009, CIRCULATION, V119, P2103, DOI 10.1161/CIRCULATIONAHA.108.843219
   DUELL PB, 1991, DIABETES, V40, P377, DOI 10.2337/diabetes.40.3.377
   Dueñas AI, 2008, CARDIOVASC RES, V79, P537, DOI 10.1093/cvr/cvn087
   Dullaart RPF, 2008, EUR J ENDOCRINOL, V158, P53, DOI 10.1530/EJE-07-0451
   Dullaart RPF, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20030732
   Dullaart RPF, 2014, CLIN CHIM ACTA, V433, P34, DOI 10.1016/j.cca.2014.02.026
   Dullaart RPF, 2008, J CLIN ENDOCR METAB, V93, P4860, DOI 10.1210/jc.2008-1213
   Duparc T, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-65100-2
   Duvillard L, 2000, ATHEROSCLEROSIS, V152, P229, DOI 10.1016/S0021-9150(99)00473-6
   Duvillard L, 2013, ARTERIOSCL THROM VAS, V33, P2460, DOI 10.1161/ATVBAHA.113.301597
   Ebtehaj S, 2019, ARTERIOSCL THROM VAS, V39, P1874, DOI 10.1161/ATVBAHA.119.312645
   Ebtehaj S, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-017-0613-8
   Elsoe S, 2012, ATHEROSCLEROSIS, V221, P91, DOI 10.1016/j.atherosclerosis.2011.11.031
   Fadini GP, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-017-0529-3
   Fall T, 2015, DIABETES, V64, P2676, DOI 10.2337/db14-1710
   Feng J, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.993193
   Festa A, 2005, CIRCULATION, V111, P3465, DOI 10.1161/CIRCULATIONAHA.104.512079
   Frenais R, 1997, DIABETOLOGIA, V40, P578, DOI 10.1007/s001250050718
   Frikke-Schmidt R, 2008, JAMA-J AM MED ASSOC, V299, P2524, DOI 10.1001/jama.299.21.2524
   Garçon D, 2022, CURR ATHEROSCLER REP, V24, P153, DOI 10.1007/s11883-022-00995-y
   Garvey WT, 2003, DIABETES, V52, P453, DOI 10.2337/diabetes.52.2.453
   Genua I, 2021, J CLIN MED, V10, DOI 10.3390/jcm10081716
   Godfrey L, 2014, NUTR DIABETES, V4, DOI 10.1038/nutd.2014.31
   Guembe MJ, 2020, CARDIOVASC DIABETOL, V19, DOI 10.1186/s12933-020-01166-6
   Guérin M, 2001, ARTERIOSCL THROM VAS, V21, P282, DOI 10.1161/01.ATV.21.2.282
   Guerin M, 2018, J AM COLL CARDIOL, V72, P3259, DOI 10.1016/j.jacc.2018.09.080
   Haase CL, 2012, J CLIN ENDOCR METAB, V97, pE248, DOI 10.1210/jc.2011-1846
   Hadfield KA, 2013, BIOCHEM J, V449, P531, DOI 10.1042/BJ20121210
   Haffner SM, 1998, NEW ENGL J MED, V339, P229, DOI 10.1056/NEJM199807233390404
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Hansel B, 2016, J CLIN LIPIDOL, V10, P1172, DOI 10.1016/j.jacl.2016.05.008
   He X, 2019, LIFE SCI, V216, P67, DOI 10.1016/j.lfs.2018.09.024
   He Y, 2020, CIRC RES, V127, P1198, DOI 10.1161/CIRCRESAHA.120.317178
   Hirano T, 2018, J ATHEROSCLER THROMB, V25, P771, DOI 10.5551/jat.RV17023
   Hirayama S, 2007, DIABETES CARE, V30, P1289, DOI 10.2337/dc06-1948
   Hoang A, 2007, DIABETOLOGIA, V50, P1770, DOI 10.1007/s00125-007-0718-9
   Holzer M, 2022, J LIPID RES, V63, DOI 10.1016/j.jlr.2022.100307
   Holzer M, 2012, ANTIOXID REDOX SIGN, V17, P1043, DOI 10.1089/ars.2011.4403
   Holzer M, 2011, ANTIOXID REDOX SIGN, V14, P2337, DOI 10.1089/ars.2010.3640
   HOROWITZ BS, 1993, J CLIN INVEST, V91, P1743, DOI 10.1172/JCI116384
   Hu PL, 2016, DIABETES RES CLIN PR, V122, P179, DOI 10.1016/j.diabres.2016.10.019
   Huang JS, 2023, MOL METAB, V67, DOI 10.1016/j.molmet.2022.101651
   Iwakiri Y, 2011, NITRIC OXIDE-BIOL CH, V25, P95, DOI 10.1016/j.niox.2011.04.014
   Izquierdo MC, 2022, J CLIN INVEST, V132, DOI 10.1172/JCI146219
   Jackisch L, 2018, DIABETOLOGIA, V61, P1155, DOI 10.1007/s00125-018-4558-6
   Jia CZ, 2021, CIRCULATION, V143, P1935, DOI 10.1161/CIRCULATIONAHA.120.050808
   Kappelle PJWH, 2012, EUR J CLIN INVEST, V42, P487, DOI 10.1111/j.1365-2362.2011.02604.x
   Kashyap SR, 2018, J CLIN ENDOCR METAB, V103, P388, DOI 10.1210/jc.2017-01551
   Kawachi E, 2019, TOB INDUC DIS, V17, P22, DOI 10.18332/tid/111387
   Kheniser KG, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10040520
   Khera AV, 2017, CIRCULATION, V135, P2494, DOI 10.1161/CIRCULATIONAHA.116.025678
   Kjerulf DG, 2020, J DIABETES COMPLICAT, V34, DOI 10.1016/j.jdiacomp.2020.107693
   Ko DT, 2016, J AM COLL CARDIOL, V68, P2073, DOI 10.1016/j.jacc.2016.08.038
   Kobayashi T, 2021, J ATHEROSCLER THROMB, V28, P730, DOI 10.5551/jat.55699
   Kontush A, 2005, ATHEROSCLEROSIS, V182, P277, DOI 10.1016/j.atherosclerosis.2005.03.001
   Kontush A, 2007, ARTERIOSCL THROM VAS, V27, P1843, DOI 10.1161/ATVBAHA.107.145672
   Kostara CE, 2022, METABOLITES, V12, DOI 10.3390/metabo12080683
   Kronenberg F, 2000, J AM COLL CARDIOL, V36, P751, DOI 10.1016/S0735-1097(00)00775-0
   Kurano M, 2020, DIABETES, V69, P867, DOI 10.2337/db19-0811
   Lamarche B, 1999, J CLIN INVEST, V103, P1191, DOI 10.1172/JCI5286
   Lincoff AM, 2017, NEW ENGL J MED, V376, P1933, DOI 10.1056/NEJMoa1609581
   Liu C, 2022, JAMA CARDIOL, V7, P672, DOI 10.1001/jamacardio.2022.0912
   Liu C, 2022, AM J CARDIOL, V167, P43, DOI 10.1016/j.amjcard.2021.11.041
   Liu D, 2018, J MOL CELL CARDIOL, V122, P47, DOI 10.1016/j.yjmcc.2018.08.001
   Liu DH, 2012, DIABETES-METAB RES, V28, P186, DOI 10.1002/dmrr.1297
   Lorkowski SW, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10040551
   Low H, 2012, DIABETOLOGIA, V55, P2513, DOI 10.1007/s00125-012-2570-9
   Lucero D, 2015, ATHEROSCLEROSIS, V242, P236, DOI 10.1016/j.atherosclerosis.2015.07.019
   Lui DTW, 2021, DIABETES CARE, V44, P804, DOI 10.2337/dc20-2186
   Luo F, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-02080-w
   Machado AP, 2006, INT J BIOCHEM CELL B, V38, P392, DOI 10.1016/j.biocel.2005.09.016
   Madsen CM, 2017, EUR HEART J, V38, P2478, DOI 10.1093/eurheartj/ehx163
   Mahajan A, 2018, NAT GENET, V50, P1505, DOI 10.1038/s41588-018-0241-6
   Maranghi M, 2011, ATHEROSCLEROSIS, V219, P259, DOI 10.1016/j.atherosclerosis.2011.05.018
   Marin MT, 2015, J DIABETES COMPLICAT, V29, P679, DOI 10.1016/j.jdiacomp.2015.03.015
   Marshall HE, 2001, BIOCHEMISTRY-US, V40, P1688, DOI 10.1021/bi002239y
   Mastorikou M, 2008, DIABETIC MED, V25, P1049, DOI 10.1111/j.1464-5491.2008.02546.x
   Matsuki K, 2009, ATHEROSCLEROSIS, V206, P434, DOI 10.1016/j.atherosclerosis.2009.03.003
   McGrath KCY, 2009, ARTERIOSCL THROM VAS, V29, P877, DOI 10.1161/ATVBAHA.109.184663
   Memon AA, 2014, NUTR METAB CARDIOVAS, V24, P1174, DOI 10.1016/j.numecd.2014.05.007
   Metzinger MP, 2020, J AM HEART ASSOC, V9, DOI 10.1161/JAHA.120.018136
   Mineo C, 2003, J BIOL CHEM, V278, P9142, DOI 10.1074/jbc.M211394200
   Mocciaro G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23126786
   Mora S, 2010, DIABETES, V59, P1153, DOI 10.2337/db09-1114
   Morgantini C, 2011, DIABETES, V60, P2617, DOI 10.2337/db11-0378
   Moya MD, 2012, ATHEROSCLEROSIS, V222, P390, DOI 10.1016/j.atherosclerosis.2012.02.032
   Mughal SA, 2013, DIABETIC MED, V30, P246, DOI 10.1111/dme.12066
   Murakami H, 2013, DIABETES RES CLIN PR, V99, P30, DOI 10.1016/j.diabres.2012.10.022
   Murakami K, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-28953-x
   Mutharasan RK, 2017, J LIPID RES, V58, P600, DOI 10.1194/jlr.P069039
   Nelson TL, 2011, DIABETOLOGIA, V54, P329, DOI 10.1007/s00125-010-1969-4
   Nicholls SJ, 2017, ATHEROSCLEROSIS, V261, P12, DOI 10.1016/j.atherosclerosis.2017.04.008
   Nilsson O, 2020, BBA-MOL BASIS DIS, V1866, DOI 10.1016/j.bbadis.2019.165613
   Nobecourt E, 2007, DIABETOLOGIA, V50, P643, DOI 10.1007/s00125-006-0574-z
   Nobécourt E, 2005, DIABETOLOGIA, V48, P529, DOI 10.1007/s00125-004-1655-5
   Nofer JR, 2001, J BIOL CHEM, V276, P34480, DOI 10.1074/jbc.M103782200
   Nofer JR, 2004, J CLIN INVEST, V113, P569, DOI 10.1172/JCI200418004
   Noor R, 2007, ATHEROSCLEROSIS, V192, P92, DOI 10.1016/j.atherosclerosis.2006.06.023
   Ooi EMM, 2008, J CLIN ENDOCR METAB, V93, P430, DOI 10.1210/jc.2007-0854
   Ossoli A, 2019, ARTERIOSCL THROM VAS, V39, P915, DOI 10.1161/ATVBAHA.118.311987
   Osto E, 2015, CIRCULATION, V131, P871, DOI 10.1161/CIRCULATIONAHA.114.011791
   Palumbo M, 2022, FRONT MOL BIOSCI, V9, DOI 10.3389/fmolb.2022.925587
   Passarelli M, 2000, CLIN CHIM ACTA, V301, P119, DOI 10.1016/S0009-8981(00)00336-3
   Patel S, 2009, J AM COLL CARDIOL, V53, P962, DOI 10.1016/j.jacc.2008.12.008
   Pérez L, 2019, LAB INVEST, V99, P421, DOI 10.1038/s41374-018-0151-3
   Perségol L, 2014, J CLIN ENDOCR METAB, V99, pE2015, DOI 10.1210/jc.2014-2078
   Pétremand J, 2012, DIABETES, V61, P1100, DOI 10.2337/db11-1221
   Plomgaard P, 2009, J INTERN MED, V266, P258, DOI 10.1111/j.1365-2796.2009.02095.x
   Pont F, 2002, INT J OBESITY, V26, P1151, DOI 10.1038/sj.ijo.0802070
   Powell-Wiley TM, 2021, CIRCULATION, V143, pE984, DOI 10.1161/CIR.0000000000000973
   Qu J, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8040319
   Rashduni DL, 1999, METABOLISM, V48, P139, DOI 10.1016/S0026-0495(99)90024-0
   Rohatgi A, 2014, NEW ENGL J MED, V371, P2383, DOI 10.1056/NEJMoa1409065
   Rouland A, 2022, CARDIOVASC DIABETOL, V21, DOI 10.1186/s12933-022-01703-5
   Ruiz M, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0429-2
   Ruiz M, 2017, ARTERIOSCL THROM VAS, V37, P118, DOI 10.1161/ATVBAHA.116.308435
   Saleheen D, 2015, LANCET DIABETES ENDO, V3, P507, DOI 10.1016/S2213-8587(15)00126-6
   Sang H, 2015, J CLIN ENDOCR METAB, V100, P870, DOI 10.1210/jc.2014-2979
   Sanguinetti SM, 2001, DIABETES NUTR METAB, V14, P27
   Sartore G, 2015, NUTR METAB CARDIOVAS, V25, P418, DOI 10.1016/j.numecd.2014.12.004
   Sattler K, 2015, J AM COLL CARDIOL, V66, P1470, DOI 10.1016/j.jacc.2015.07.057
   Sattler K, 2014, CELL PHYSIOL BIOCHEM, V34, P172, DOI 10.1159/000362993
   Schwendeman A, 2015, J LIPID RES, V56, P1727, DOI 10.1194/jlr.M060285
   Seo MH, 2011, J CLIN ENDOCR METAB, V96, pE2050, DOI 10.1210/jc.2011-1857
   Shao BH, 2008, P NATL ACAD SCI USA, V105, P12224, DOI 10.1073/pnas.0802025105
   Shao BH, 2010, J BIOL CHEM, V285, P18473, DOI 10.1074/jbc.M110.118182
   Shiu SW, 2017, ATHEROSCLEROSIS, V263, P24, DOI 10.1016/j.atherosclerosis.2017.05.031
   Shiu SWM, 2008, ATHEROSCLEROSIS, V198, P441, DOI 10.1016/j.atherosclerosis.2008.03.012
   Shiu SWM, 2014, CLIN SCI, V126, P175, DOI 10.1042/CS20130369
   Shiu SWM, 2010, J DIABETES INVEST, V1, P111, DOI 10.1111/j.2040-1124.2010.00016.x
   Sokooti S, 2021, J CLIN ENDOCR METAB, V106, P1761, DOI 10.1210/clinem/dgab075
   Sorrentino SA, 2010, CIRCULATION, V121, P110, DOI 10.1161/CIRCULATIONAHA.108.836346
   SPARKS DL, 1995, J BIOL CHEM, V270, P26910, DOI 10.1074/jbc.270.45.26910
   Ståhlman M, 2013, BBA-MOL CELL BIOL L, V1831, P1609, DOI 10.1016/j.bbalip.2013.07.009
   Stenkula KG, 2014, DIABETOLOGIA, V57, P797, DOI 10.1007/s00125-014-3162-7
   Subbaiah PV, 2005, J LIPID RES, V46, P2699, DOI 10.1194/jlr.M500263-JLR200
   Sutter I, 2015, ATHEROSCLEROSIS, V241, P539, DOI 10.1016/j.atherosclerosis.2015.05.037
   Syvanne M, 1996, ATHEROSCLEROSIS, V127, P245, DOI 10.1016/S0021-9150(96)05962-X
   Tabara Y, 2017, DIABETES RES CLIN PR, V127, P123, DOI 10.1016/j.diabres.2017.03.018
   Takata K, 2014, CIRC J, V78, P2955, DOI 10.1253/circj.CJ-14-0638
   Tan KCB, 2020, CLIN J AM SOC NEPHRO, V15, P359, DOI 10.2215/CJN.11710919
   Tang SD, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-38014-3
   Taradeh M, 2022, ATHEROSCLEROSIS, V355, pE154
   Terasaka N, 2010, ARTERIOSCL THROM VAS, V30, P2219, DOI 10.1161/ATVBAHA.110.213215
   Thakkar H, 2021, DIABETOL METAB SYNDR, V13, DOI 10.1186/s13098-021-00662-3
   Tölle M, 2008, ARTERIOSCL THROM VAS, V28, P1542, DOI 10.1161/ATVBAHA.107.161042
   Tong XL, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-27
   Triolo M, 2014, EUR J CLIN INVEST, V44, P240, DOI 10.1111/eci.12226
   Tsun JGS, 2013, ATHEROSCLEROSIS, V231, P405, DOI 10.1016/j.atherosclerosis.2013.10.008
   uc.edu, HDL PROTEOME WATCH P
   Vaisar T, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0192616
   Vaisar T, 2015, J LIPID RES, V56, P1519, DOI 10.1194/jlr.M059089
   Van Lenten BJ, 2008, J LIPID RES, V49, P2302, DOI 10.1194/jlr.M800075-JLR200
   van Tienhoven-Wind LJN, 2018, CLIN ENDOCRINOL, V88, P752, DOI 10.1111/cen.13570
   Verges B, 2006, ARTERIOSCL THROM VAS, V26, P1364, DOI 10.1161/01.ATV.0000219611.50066.bd
   Vergès B, 2016, J CLIN ENDOCR METAB, V101, P1398, DOI 10.1210/jc.2015-3740
   Vergès B, 2014, J CLIN ENDOCR METAB, V99, P4281, DOI 10.1210/jc.2014-2365
   Vergés B, 2009, J LIPID RES, V50, P1209, DOI 10.1194/jlr.P800040-JLR200
   von Eckardstein A, 2023, EUR HEART J, V44, P1394, DOI 10.1093/eurheartj/ehac605
   Wang Z, 2007, NAT MED, V13, P1176, DOI 10.1038/nm1637
   White J, 2016, JAMA CARDIOL, V1, P692, DOI 10.1001/jamacardio.2016.1884
   Wiersma JJ, 2008, MED SCI MONITOR, V14, pCR406
   Wilson PWF, 2007, ARCH INTERN MED, V167, P1068, DOI 10.1001/archinte.167.10.1068
   WILSON PWF, 1988, ARTERIOSCLEROSIS, V8, P737, DOI 10.1161/01.ATV.8.6.737
   Wu BJ, 2013, CIRC RES, V112, P278, DOI 10.1161/CIRCRESAHA.111.300104
   Yancey PG, 2004, J LIPID RES, V45, P337, DOI 10.1194/jlr.M300231-JLR200
   Yassine HN, 2014, METABOLISM, V63, P727, DOI 10.1016/j.metabol.2014.03.001
   Yuhanna IS, 2001, NAT MED, V7, P853, DOI 10.1038/89986
   Zanoni P, 2016, SCIENCE, V351, P1166, DOI 10.1126/science.aad3517
   Zhang PH, 2016, LIPIDS HEALTH DIS, V15, DOI 10.1186/s12944-016-0325-1
   Zhang XY, 2007, BBA-MOL CELL BIOL L, V1771, P879, DOI 10.1016/j.bbalip.2007.04.020
   Zhao D, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-016-0450-1
   Zhou HL, 2009, DIABETES VASC DIS RE, V6, P238, DOI 10.1177/1479164109344934
   Zhou HL, 2008, DIABETES-METAB RES, V24, P617, DOI 10.1002/dmrr.895
NR 211
TC 19
Z9 20
U1 1
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD FEB
PY 2023
VL 13
IS 2
AR 253
DI 10.3390/metabo13020253
PG 26
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 9J9OU
UT WOS:000940507600001
PM 36837872
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Xu, MY
   Zhong, FY
   Bruno, RS
   Ballard, KD
   Zhang, J
   Zhu, JJ
AF Xu, Mengyang
   Zhong, Fanyi
   Bruno, Richard S.
   Ballard, Kevin D.
   Zhang, Jing
   Zhu, Jiangjiang
TI Comparative Metabolomics Elucidates Postprandial Metabolic Modifications
   in Plasma of Obese Individuals with Metabolic Syndrome
SO JOURNAL OF PROTEOME RESEARCH
LA English
DT Article
DE targeted metabolic profiling nutrimetabolomics; low-fat milk; rice milk;
   Bayesian LASSO
ID VASCULAR ENDOTHELIAL FUNCTION; MASS-SPECTROMETRY; EPIDEMIOLOGY; WATER;
   DIET
AB Although higher intakes of dairy milk are associated with a lower risk of metabolic syndrome (MetS), the underlying protective mechanism remains unclear. This study investigated the dynamic metabolic profile shift following the ingestion of low-fat milk or an isocaloric volume of rice milk in obese individuals with metabolic syndrome (MetS). In a randomized, double-blind, crossover study, postprandial plasma samples (n = 266) were collected from 19 MetS participants. Plasma samples were analyzed by a targeted metabolomics platform which specifically detects 117 metabolites from 25 metabolic pathways. The comprehensive time course metabolic profiling in MetS participants indicated that the postprandial metabolic profiles distinguish low-fat milk and rice milk consumption in a time-dependent manner. Metabolic biomarkers, such as orotate, leucine/isoleucine and adenine, showed significantly different trends in the two test beverages. Bayesian statistics identified 12 metabolites associated with clinical characteristics of postprandial vascular endothelial function, such as flow-mediated dilation (FMD), postprandial plasma markers of oxidative stress and NO status. Furthermore, metabolic pathway analysis based on these metabolite data indicated the potential utility of metabolomics to provide mechanistic insights of dietary interventions to regulate postprandial metabolic excursions.
C1 [Xu, Mengyang; Zhong, Fanyi; Zhu, Jiangjiang] Miami Univ, Dept Chem & Biochem, Oxford, OH 45056 USA.
   [Bruno, Richard S.] Ohio State Univ, Human Nutr Program, Columbus, OH 43210 USA.
   [Ballard, Kevin D.] Miami Univ, Dept Kinesiol & Hlth, Oxford, OH 45056 USA.
   [Zhang, Jing] Miami Univ, Dept Stat, Oxford, OH 45056 USA.
C3 University System of Ohio; Miami University; University System of Ohio;
   Ohio State University; University System of Ohio; Miami University;
   University System of Ohio; Miami University
RP Zhu, JJ (corresponding author), Miami Univ, Dept Chem & Biochem, Oxford, OH 45056 USA.
EM zhuj6@miamioh.edu
RI Xu, Meng/HJY-7139-2023; Zhu, Jiangjiang/E-4202-2013; Bruno,
   Richard/K-1930-2012
OI Bruno, Richard/0000-0002-6772-2038
FU Miami University; National Dairy Council
FX This study was supported by Miami University (startup fund to JZ) and a
   grant from the National Dairy Council (to RSB). We'd like to extend our
   gratitude to the study participants.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Bajad SU, 2006, J CHROMATOGR A, V1125, P76, DOI 10.1016/j.chroma.2006.05.019
   Ballard KD, 2015, NUTR REV, V73, P36, DOI 10.1093/nutrit/nuu013
   Ballard KD, 2013, J NUTR, V143, P1602, DOI 10.3945/jn.113.179465
   Brosnan ME, 2007, J NUTR, V137, p1656S, DOI 10.1093/jn/137.6.1656S
   Cynober LA, 2002, NUTRITION, V18, P761, DOI 10.1016/S0899-9007(02)00780-3
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Jenab M, 2009, HUM GENET, V125, P507, DOI 10.1007/s00439-009-0662-5
   Kipnis V, 2002, PUBLIC HEALTH NUTR, V5, P915, DOI 10.1079/PHN2002383
   Lutsey PL, 2008, CIRCULATION, V117, P754, DOI 10.1161/CIRCULATIONAHA.107.716159
   Mah E, 2011, J NUTR, V141, P1961, DOI 10.3945/jn.111.144592
   O'Gorman A, 2013, COMPUT STRUCT BIOTEC, V4, DOI 10.5936/csbj.201301004
   Schelli K, 2017, J CHROMATOGR B, V1047, P124, DOI 10.1016/j.jchromb.2016.05.052
   Seale JL, 2002, NUTRITION, V18, P568, DOI 10.1016/S0899-9007(02)00804-3
   Smilde AK, 2005, BIOINFORMATICS, V21, P3043, DOI 10.1093/bioinformatics/bti476
   Swinburn BA, 2004, PUBLIC HEALTH NUTR, V7, P123, DOI 10.1079/PHN2003585
   Xia JG, 2015, NUCLEIC ACIDS RES, V43, pW251, DOI 10.1093/nar/gkv380
   Yuan M, 2012, NAT PROTOC, V7, P872, DOI 10.1038/nprot.2012.024
   Zamora-Ros R, 2012, J AGR FOOD CHEM, V60, P6648, DOI 10.1021/jf204742e
   Zhu JJ, 2015, ANAL BIOANAL CHEM, V407, P7857, DOI 10.1007/s00216-015-8984-8
   Zhu JJ, 2014, J PROTEOME RES, V13, P4120, DOI 10.1021/pr500494u
   Zhu YD, 2016, SCI REP-UK, V6, DOI 10.1038/srep36278
NR 22
TC 9
Z9 9
U1 0
U2 19
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1535-3893
EI 1535-3907
J9 J PROTEOME RES
JI J. Proteome Res.
PD AUG
PY 2018
VL 17
IS 8
BP 2850
EP 2860
DI 10.1021/acs.jproteome.8b00315
PG 11
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA GP7TQ
UT WOS:000441112800027
PM 29975061
DA 2025-06-11
ER

PT J
AU Ko, KD
   Cho, B
   Lee, WC
   Lee, HW
   Lee, HK
   Oh, BJ
AF Ko, Ki Dong
   Cho, BeLong
   Lee, Won Chul
   Lee, Hae Won
   Lee, Hyun Ki
   Oh, Bum Jo
TI Obesity Explains Gender Differences in the Association Between Education
   Level and Metabolic Syndrome in South Korea: The Results From the Korean
   National Health and Nutrition Examination Survey 2010
SO ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH
LA English
DT Article
DE metabolic syndrome; educational level; gender differences
ID SOCIOECONOMIC-STATUS; ABDOMINAL OBESITY; URBAN-POPULATION; RISK;
   PREVALENCE; ADULTS; DISPARITIES; DIAGNOSIS; CANCER
AB This study aimed to examine the association of educational level with metabolic syndrome (MS) and its risk factors by gender in South Korea. A total of 6178 participants aged 20 years or older from The Fifth Korean National Health and Nutrition Examination Survey were included in this study. A generalized linear model and adjusted proportion were used to identify educational disparities in MS, its components, and its risk factors (smoking, high-risk alcohol consumption, obesity, and stress). In women, a clearly inverse association between education level and MS were observed with significant trend, and the decreasing trends of all risk factors across education quartiles were in line with the inverse association. However, the association between education level and MS was not observed with a significant trend among men. An opposite trend of risk factors across education levels was shown in men, with an increasing trend for obesity and decreasing trends for smoking and high-risk alcohol consumption. These findings demonstrate that obesity can explain gender differences in the association between education level and MS in South Korea.
C1 [Ko, Ki Dong] Gachon Univ, Inchon, South Korea.
   [Cho, BeLong; Lee, Hae Won; Lee, Hyun Ki; Oh, Bum Jo] Seoul Natl Univ Hosp, Seoul 110744, South Korea.
   [Lee, Won Chul] Catholic Univ Korea, Seoul, South Korea.
C3 Gachon University; Seoul National University (SNU); Seoul National
   University Hospital; Catholic University of Korea
RP Cho, B (corresponding author), Seoul Natl Univ, Coll Med, Seoul Natl Univ Hosp, Dept Family Med, 110-744 101 Daehangno, Seoul, South Korea.
EM belong.cho@gmail.com
RI Oh, Bumjo/GWN-2776-2022; Cho, Belong/GLU-3443-2022; Lee,
   Eun-Hye/KDN-5679-2024; Oh, Bumjo/O-2462-2017
OI Oh, Bumjo/0000-0002-2468-0755
CR Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   [Anonymous], 2000, ASIA PACIFIC PERSPEC
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   Björntorp P, 2000, BRIT J NUTR, V83, pS49, DOI 10.1017/S0007114500000957
   Boissonnet C, 2011, EUR J CARDIOV PREV R, V18, P550, DOI 10.1177/1741826710389418
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Dallongeville J, 2005, DIABETES CARE, V28, P409, DOI 10.2337/diacare.28.2.409
   Ferguson TS, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-307
   Ford ES, 2008, CARDIOVASC DIABETOL, V7, DOI 10.1186/1475-2840-7-35
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   *INT OB TASK FORC, 2002, AS PAC PERSP RED OB
   Kaduka LU, 2012, DIABETES CARE, V35, P887, DOI 10.2337/dc11-0537
   Klumbiene J, 2004, EUR J PUBLIC HEALTH, V14, P390, DOI 10.1093/eurpub/14.4.390
   Ko KD, 2011, ARCH PHYS MED REHAB, V92, P1230, DOI 10.1016/j.apmr.2011.03.004
   Lee SY, 2007, DIABETES RES CLIN PR, V75, P72, DOI 10.1016/j.diabres.2006.04.013
   LIBERATOS P, 1988, EPIDEMIOL REV, V10, P87, DOI 10.1093/oxfordjournals.epirev.a036030
   Lidfeldt J, 2003, DIABETES OBES METAB, V5, P106, DOI 10.1046/j.1463-1326.2003.00250.x
   Lim S, 2011, DIABETES CARE, V34, P1323, DOI 10.2337/dc10-2109
   Loucks EB, 2007, ANN EPIDEMIOL, V17, P19, DOI 10.1016/j.annepidem.2006.07.002
   Misra A, 2009, METAB SYNDR RELAT D, V7, P497, DOI 10.1089/met.2009.0024
   Mohan V, 2001, DIABETIC MED, V18, P280, DOI 10.1046/j.1464-5491.2001.00421.x
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Nielsen L, 2008, SCAND J PUBLIC HEALT, V36, P369, DOI 10.1177/1403494807088456
   Osaki Y, 2012, CANCER EPIDEMIOL, V36, P141, DOI 10.1016/j.canep.2011.03.007
   Park Bo Hyun, 2009, J Prev Med Public Health, V42, P275, DOI 10.3961/jpmph.2009.42.5.275
   Park HS, 2004, INT J EPIDEMIOL, V33, P328, DOI 10.1093/ije/dyh032
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Russo A, 2008, EUR J CANCER, V44, P293, DOI 10.1016/j.ejca.2007.11.005
   Sánchez-Chaparro MA, 2008, DIABETES CARE, V31, P1884, DOI 10.2337/dc08-0431
   Santos AC, 2008, BMC PUBLIC HEALTH, V8, DOI 10.1186/1471-2458-8-62
   Swendsen J, 2009, ADDICTION, V104, P1346, DOI 10.1111/j.1360-0443.2009.02622.x
   Tan AKG, 2011, ASIA-PAC J PUBLIC HE, V23, P192, DOI 10.1177/1010539509359535
   Wetter DW, 2005, ADDICT BEHAV, V30, P905, DOI 10.1016/j.addbeh.2004.09.006
   Yoon YS, 2006, OBESITY, V14, P909, DOI 10.1038/oby.2006.105
NR 34
TC 3
Z9 3
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1010-5395
EI 1941-2479
J9 ASIA-PAC J PUBLIC HE
JI Asia-Pac. J. Public Health
PD MAR
PY 2015
VL 27
IS 2
BP NP630
EP NP639
DI 10.1177/1010539513488624
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA CF5GT
UT WOS:000352586200063
PM 23687256
DA 2025-06-11
ER

PT J
AU Bestermann, WH
AF Bestermann, William H., Jr.
TI The ADMA-Metformin Hypothesis: Linking the Cardiovascular Consequences
   of the Metabolic Syndrome and Type 2 Diabetes
SO CARDIORENAL MEDICINE
LA English
DT Article
DE ADMA; Asymmetric dimethylarginine; Diabetes type 2; Hyperlipidemia;
   Hypertension; Insulin resistance; Metabolic syndrome; Metformin
ID NITRIC-OXIDE SYNTHASE; RIBOSOMAL-PROTEIN S6-KINASE-1; ASYMMETRIC
   DIMETHYLARGININE; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   EPITHELIAL-CELLS; HYPERTENSION; DIMETHYLAMINOHYDROLASE; PATHWAY;
   DYSFUNCTION
AB Metformin and asymmetric dimethylarginine (ADMA) are structural analogs. They have opposite effects at multiple points on complex signaling pathways that coordinate energy, molecular synthesis, growth, and metabolism with nutrient intake. Excess saturated fats and glucose may initiate the methylation of arginine residues in proteins involved in the transcription of genes mediating inflammation, cell proliferation, apoptosis, and oncogenesis. Free ADMA may appear in the circulation after proteolysis of these proteins when the work of transcription is complete and ADMA subsequently functions as a signaling molecule. In children, ADMA levels are not significantly related to the usual metabolic syndrome risk factors but instead there is a significant association between ADMA and alkaline phosphatase a marker of normal growth. There is only one direct study that shows that ADMA negates the metabolic effects of metformin. There are no investigations that demonstrate that metformin blocks the effect of ADMA and so this review must be considered hypothesis generating. The potential implications of the metformin-ADMA relationship merit further investigation. Copyright (c) 2011 S. Karger AG, Basel
C1 [Bestermann, William H., Jr.] Vasc Med Ctr, Holston Med Grp, Kingsport, TN USA.
RP Bestermann, WH (corresponding author), 105 W Stone Dr, Kingsport, TN 37660 USA.
EM whb@hmgkpt.com
RI Bestermann, William/GPX-2901-2022
CR Achan V, 2003, ARTERIOSCL THROM VAS, V23, P1455, DOI 10.1161/01.ATV.0000081742.92006.59
   Adcock IM, 2006, RESP RES, V7, DOI 10.1186/1465-9921-7-21
   Balletshofer BM, 2000, CIRCULATION, V101, P1780, DOI 10.1161/01.CIR.101.15.1780
   BARON AD, 1995, AM J PHYSIOL-ENDOC M, V269, pE709, DOI 10.1152/ajpendo.1995.269.4.E709
   Boulay A, 2004, CANCER RES, V64, P252, DOI 10.1158/0008-5472.CAN-3554-2
   Calvert JW, 2008, DIABETES, V57, P696, DOI 10.2337/db07-1098
   Chen MF, 2007, J VASC RES, V44, P391, DOI 10.1159/000103284
   Cooke JP, 2004, CIRCULATION, V109, P1813, DOI 10.1161/01.CIR.0000126823.07732.D5
   Cooke JP, 2000, VASC MED, V5, P49, DOI 10.1177/1358836X0000500108
   Detaille D, 2002, BIOCHEM PHARMACOL, V63, P1259, DOI 10.1016/S0006-2952(02)00858-4
   Ding G, 2007, AM J PHYSIOL-RENAL, V293, pF1889, DOI 10.1152/ajprenal.00112.2007
   Duplain H, 2001, CIRCULATION, V104, P342, DOI 10.1161/01.CIR.104.3.342
   Eskan MA, 2008, INFECT IMMUN, V76, P2080, DOI 10.1128/IAI.01428-07
   Fard A, 2000, ARTERIOSCL THROM VAS, V20, P2039, DOI 10.1161/01.ATV.20.9.2039
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   Gruber HJ, 2008, EXP CLIN ENDOCR DIAB, V116, P520, DOI 10.1055/s-2008-1062712
   Hardie DG, 2006, J PHYSIOL-LONDON, V574, P7, DOI 10.1113/jphysiol.2006.108944
   Huang SM, 2009, AM J PHYSIOL-RENAL, V296, pF1323, DOI 10.1152/ajprenal.90428.2008
   Isoda K, 2006, ARTERIOSCL THROM VAS, V26, P611, DOI 10.1161/01.ATV.0000201938.78044.75
   Johannes F, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000530
   Kalender A, 2010, CELL METAB, V11, P390, DOI 10.1016/j.cmet.2010.03.014
   Kielstein JT, 2004, CIRCULATION, V109, P172, DOI 10.1161/01.CIR.0000105764.22626.B1
   Kirpichnikov D, 2002, ANN INTERN MED, V137, P25, DOI 10.7326/0003-4819-137-1-200207020-00009
   Lin KY, 2002, CIRCULATION, V106, P987, DOI 10.1161/01.CIR.0000027109.14149.67
   Marchetti P, 2004, J CLIN ENDOCR METAB, V89, P5535, DOI 10.1210/jc.2004-0150
   MARIGLIANO A, 1990, AM J HYPERTENS, V3, P521, DOI 10.1093/ajh/3.7.521
   Masuda H, 1999, BRIT J PHARMACOL, V126, P211, DOI 10.1038/sj.bjp.0702298
   Motoshima H, 2006, J PHYSIOL-LONDON, V574, P63, DOI 10.1113/jphysiol.2006.108324
   Santa Maria J, 1999, MOL MICROBIOL, V33, P1278, DOI 10.1046/j.1365-2958.1999.01580.x
   Smith CL, 2005, PLOS MED, V2, P1031, DOI 10.1371/journal.pmed.0020264
   Sowers JR, 2009, ANN INTERN MED, V150, P776, DOI 10.7326/0003-4819-150-11-200906020-00005
   Stühlinger MC, 2002, JAMA-J AM MED ASSOC, V287, P1420, DOI 10.1001/jama.287.11.1420
   Sud N, 2008, AM J PHYSIOL-CELL PH, V294, pC1407, DOI 10.1152/ajpcell.00384.2007
   Suda O, 2004, ARTERIOSCL THROM VAS, V24, P1682, DOI 10.1161/01.ATV.0000136656.26019.6e
   Sydow K, 2005, VASC MED, V10, pS35, DOI 10.1191/1358863x05vm604oa
   Sydow K, 2003, ATHEROSCLEROSIS SUPP, V4, P41, DOI 10.1016/S1567-5688(03)00033-3
   Um SH, 2006, CELL METAB, V3, P393, DOI 10.1016/j.cmet.2006.05.003
   Vallance P, 2004, ARTERIOSCL THROM VAS, V24, P1023, DOI 10.1161/01.ATV.0000128897.54893.26
   Villeneuve LM, 2008, P NATL ACAD SCI USA, V105, P9047, DOI 10.1073/pnas.0803623105
   Wells SM, 2007, AM J RESP CELL MOL, V36, P520, DOI 10.1165/rcmb.2006-0302SM
   Wu GY, 1998, BIOCHEM J, V336, P1, DOI 10.1042/bj3360001
   Yang ZC, 2009, CELL PHYSIOL BIOCHEM, V24, P115, DOI 10.1159/000227819
   Yeni-Komshian H, 2000, DIABETES CARE, V23, P171, DOI 10.2337/diacare.23.2.171
   Zakrzewicz Dariusz, 2009, BMC Pulm Med, V9, P5, DOI 10.1186/1471-2466-9-5
   Zhuang Yongxian, 2008, J Mol Signal, V3, P18, DOI 10.1186/1750-2187-3-18
NR 45
TC 25
Z9 26
U1 0
U2 3
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1664-3828
EI 1664-5502
J9 CARDIORENAL MED
JI CardioRenal Med.
PY 2011
VL 1
IS 4
BP 211
EP 219
DI 10.1159/000332382
PG 9
WC Cardiac & Cardiovascular Systems; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Urology & Nephrology
GA 051ZN
UT WOS:000312167600001
PM 22135630
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Elenkov, IJ
   Iezzoni, DG
   Daly, A
   Harris, AG
   Chrousos, GP
AF Elenkov, IJ
   Iezzoni, DG
   Daly, A
   Harris, AG
   Chrousos, GP
TI Cytokine dysregulation, inflammation and well-being
SO NEUROIMMUNOMODULATION
LA English
DT Review
DE autoimmune diseases; cytokines; inflammation; interleukins; stress;
   tumor necrosis factor
ID TUMOR-NECROSIS-FACTOR; CORTICOTROPIN-RELEASING HORMONE;
   PITUITARY-ADRENAL AXIS; GENE-RELATED PEPTIDE; MINIMAL PERSISTENT
   INFLAMMATION; RESPIRATORY-DISTRESS-SYNDROME; INDUCED IL-12 PRODUCTION;
   MAST-CELL DEGRANULATION; FACTOR-ALPHA RELEASE; T-CELLS
AB Cytokines mediate and control immune and inflammatory responses. Complex interactions exist between cytokines, inflammation and the adaptive responses in maintaining homeostasis, health, and well-being. Like the stress response, the inflammatory reaction is crucial for survival and is meant to be tailored to the stimulus and time. A full-fledged systemic inflammatory reaction results in stimulation of four major programs: the acute-phase reaction, the sickness syndrome, the pain program, and the stress response, mediated by the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. Common human diseases such as atopy/allergy, autoimmunity, chronic infections and sepsis are characterized by a dysregulation of the pro-versus anti-inflammatory and T helper (Th)1 versus Th2 cytokine balance. Recent evidence also indicates the involvement of pro-inflammatory cytokines in the pathogenesis of atherosclerosis and major depression, and conditions such as visceral-type obesity, metabolic syndrome and sleep disturbances. During inflammation, the activation of the stress system, through induction of a Th2 shift, protects the organism from systemic 'overshooting' with Th1/pro-inflammatory cytokines. Under certain conditions, however, stress hormones may actually facilitate inflammation through induction of interleukin (IL)-1, IL-6, IL-8, IL-18, tumor necrosis factor-alpha and C-reactive protein production and through activation of the corticotropin-releasing hormone/substance P-histamine axis. Thus, a dysfunctional neuroendocrine-immune interface associated with abnormalities of the 'systemic anti-inflammatory feedback' and/or 'hyperactivity' of the local pro-inflammatory factors may play a role in the pathogenesis of atopic/allergic and autoimmune diseases, obesity, depression, and atherosclerosis. These abnormalities and the failure of the adaptive systems to resolve inflammation affect the well-being of the individual, including behavioral parameters, quality of life and sleep, as well as indices of metabolic and cardiovascular health. These hypotheses require further investigation, but the answers should provide critical insights into mechanisms underlying a variety of common human immune-related diseases. Copyright (C) 2005 S. Karger AG, Basel.
C1 NICHHD, NIH, Bethesda, MD 20892 USA.
   Georgetown Univ, Med Ctr, Div Rheumatol Allergy & Immunol, Washington, DC 20007 USA.
   Integrated Therapeut Grp Inc, Kenilworth, NJ USA.
   Univ Liege, Liege, Belgium.
   San Raffaele Res Ctr, Rome, Italy.
C3 National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver
   National Institute of Child Health & Human Development (NICHD);
   Georgetown University; University of Liege
RP NICHHD, NIH, Bldg 10,Room 1E-1-3140, Bethesda, MD 20892 USA.
EM Chrousog@mail.nih.gov
RI Daly, Adrian/E-2178-2011; Chrousos, George/G-8702-2011
OI Harris, Alan/0000-0002-6618-2092
CR Altare F, 1998, SCIENCE, V280, P1432, DOI 10.1126/science.280.5368.1432
   Arnason B G, 1988, Ann N Y Acad Sci, V540, P585, DOI 10.1111/j.1749-6632.1988.tb27181.x
   Arnason B G, 1988, Ann N Y Acad Sci, V540, P4, DOI 10.1111/j.1749-6632.1988.tb27046.x
   BAEUERLE PA, 1988, CELL, V53, P211, DOI 10.1016/0092-8674(88)90382-0
   BARNES P, 1980, NEW ENGL J MED, V303, P263, DOI 10.1056/NEJM198007313030506
   BATUMAN OA, 1995, J IMMUNOL, V155, P4397
   BAUMANN H, 1994, IMMUNOL TODAY, V15, P74, DOI 10.1016/0167-5699(94)90137-6
   Bentley AM, 1996, AM J RESP CRIT CARE, V153, P551, DOI 10.1164/ajrccm.153.2.8564096
   Black PH, 2002, BRAIN BEHAV IMMUN, V16, P622, DOI 10.1016/S0889-1591(02)00021-1
   Black PH, 2002, J PSYCHOSOM RES, V52, P1, DOI 10.1016/S0022-3999(01)00302-6
   Blotta MH, 1997, J IMMUNOL, V158, P5589
   Borger P, 1998, AM J RESP CELL MOL, V19, P400, DOI 10.1165/ajrcmb.19.3.2765
   Borovikova LV, 2000, NATURE, V405, P458, DOI 10.1038/35013070
   Bouma G, 2003, NAT REV IMMUNOL, V3, P521, DOI 10.1038/nri1132
   BRADDING P, 1995, AM J RESP CRIT CARE, V151, P1900, DOI 10.1164/ajrccm.151.6.7767538
   Broug-Holub E, 1998, AM J RESP CELL MOL, V19, P842, DOI 10.1165/ajrcmb.19.5.3103
   BrougHolub E, 1996, CLIN EXP IMMUNOL, V104, P332, DOI 10.1046/j.1365-2249.1996.29733.x
   Brune IB, 1999, AM J SURG, V177, P55, DOI 10.1016/S0002-9610(98)00299-2
   Chakfe Y, 2002, J NEUROSCI, V22, P3061, DOI 10.1523/JNEUROSCI.22-08-03061.2002
   CHROUSOS GP, 1995, NEW ENGL J MED, V332, P1351, DOI 10.1056/NEJM199505183322008
   Chrousos GP, 1998, ANN NY ACAD SCI, V851, P311, DOI 10.1111/j.1749-6632.1998.tb09006.x
   CHURCH MK, 1989, INT ARCH ALLER A IMM, V88, P70, DOI 10.1159/000234752
   Ciprandi G, 1995, J ALLERGY CLIN IMMUN, V96, P971, DOI 10.1016/S0091-6749(95)70235-0
   Clauw DJ, 1997, NEUROIMMUNOMODULAT, V4, P134, DOI 10.1159/000097332
   COHEN S, 1991, NEW ENGL J MED, V325, P606, DOI 10.1056/NEJM199108293250903
   Cole SW, 1998, J IMMUNOL, V161, P610
   Cole SW, 2001, P NATL ACAD SCI USA, V98, P12695, DOI 10.1073/pnas.221134198
   COQUERET O, 1994, ANN NY ACAD SCI, V725, P44, DOI 10.1111/j.1749-6632.1994.tb39788.x
   Corcos M, 2002, BIOMED PHARMACOTHER, V56, P105, DOI 10.1016/S0753-3322(01)00156-1
   Crofford LJ, 1997, J CLIN ENDOCR METAB, V82, P1279, DOI 10.1210/jc.82.4.1279
   CRONSTEIN BN, 1993, J CLIN INVEST, V92, P2675, DOI 10.1172/JCI116884
   CRONSTEIN BN, 1985, J IMMUNOL, V135, P1366
   DeKruyff R, 1998, J IMMUNOL, V160, P2231
   Elenkov IJ, 1999, ANN NY ACAD SCI, V876, P1, DOI 10.1111/j.1749-6632.1999.tb07618.x
   Elenkov IJ, 1999, TRENDS ENDOCRIN MET, V10, P359, DOI 10.1016/S1043-2760(99)00188-5
   Elenkov IJ, 2002, ANN NY ACAD SCI, V966, P290, DOI 10.1111/j.1749-6632.2002.tb04229.x
   Elenkov IJ, 2000, PHARMACOL REV, V52, P595
   Elenkov IJ, 1998, J IMMUNOL, V161, P2586
   Elenkov IJ, 1996, P ASSOC AM PHYSICIAN, V108, P374
   Elenkov IJ, 2001, J CLIN ENDOCR METAB, V86, P4933, DOI 10.1210/jc.86.10.4933
   ELENKOV IJ, 2003, ONLINE ENDOCRINE SOU
   Engstad CS, 1999, THROMB HAEMOSTASIS, V81, P139
   FALUS A, 1992, IMMUNOL TODAY, V13, P154
   Fearon DT, 1996, SCIENCE, V272, P50, DOI 10.1126/science.272.5258.50
   FOREMAN JC, 1987, INT ARCH ALLER A IMM, V82, P366, DOI 10.1159/000234229
   Fox FE, 1997, J INVEST DERMATOL, V108, P43, DOI 10.1111/1523-1747.ep12285627
   Franchimont D, 2002, NEUROIMMUNOMODULAT, V10, P247, DOI 10.1159/000069969
   Fuss IJ, 1999, GASTROENTEROLOGY, V117, P1078, DOI 10.1016/S0016-5085(99)70392-6
   Ganea D, 2001, MICROBES INFECT, V3, P141, DOI 10.1016/S1286-4579(00)01361-7
   Gold PW, 1999, P ASSOC AM PHYSICIAN, V111, P22, DOI 10.1046/j.1525-1381.1999.09423.x
   Gold PW, 2002, MOL PSYCHIATR, V7, P254, DOI 10.1038/sj.mp.4001032
   Greaves DR, 2002, TRENDS IMMUNOL, V23, P535, DOI 10.1016/S1471-4906(02)02331-1
   Haskó G, 1998, J NEUROIMMUNOL, V88, P57, DOI 10.1016/S0165-5728(98)00073-3
   Haskó G, 2000, BRIT J PHARMACOL, V129, P909, DOI 10.1038/sj.bjp.0703134
   Hasko G, 1996, J IMMUNOL, V157, P4634
   HETIER E, 1991, EXP BRAIN RES, V86, P407
   Ho WZ, 1998, J NEUROIMMUNOL, V82, P126, DOI 10.1016/S0165-5728(97)00175-6
   Hotchkiss RS, 2003, NEW ENGL J MED, V348, P138, DOI 10.1056/NEJMra021333
   Humbert M, 1999, IMMUNOL TODAY, V20, P528, DOI 10.1016/S0167-5699(99)01535-2
   Idzko M, 2002, J ALLERGY CLIN IMMUN, V109, P839, DOI 10.1067/mai.2002.124044
   JAREK MJ, 1993, CRIT CARE MED, V21, P543, DOI 10.1097/00003246-199304000-00015
   Johnston SL, 1996, AM J RESP CRIT CARE, V154, P654, DOI 10.1164/ajrccm.154.3.8810601
   KAPLANSKI G, 1993, BLOOD, V81, P2492
   KARALIS K, 1991, SCIENCE, V254, P421, DOI 10.1126/science.1925600
   KARASZEWSKI JW, 1993, J NEUROIMMUNOL, V43, P1, DOI 10.1016/0165-5728(93)90068-A
   KARASZEWSKI JW, 1990, ANN NEUROL, V27, P366, DOI 10.1002/ana.410270404
   Kavelaars A, 1997, J NEUROIMMUNOL, V77, P211, DOI 10.1016/S0165-5728(97)00076-3
   KincyCain T, 1997, J IMMUNOL, V158, P2334
   Kino T, 1999, J EXP MED, V189, P51, DOI 10.1084/jem.189.1.51
   KOFF WC, 1986, LYMPHOKINE RES, V5, P239
   Kronfol Z, 2000, AM J PSYCHIAT, V157, P683, DOI 10.1176/appi.ajp.157.5.683
   la Sala A, 2001, J IMMUNOL, V166, P1611, DOI 10.4049/jimmunol.166.3.1611
   Lagier B, 1997, CLIN EXP IMMUNOL, V108, P545, DOI 10.1046/j.1365-2249.1997.3791276.x
   LAPPIN D, 1984, BIOCHEM J, V222, P477, DOI 10.1042/bj2220477
   LeMoine O, 1996, J IMMUNOL, V156, P4408
   Lerner BH, 1996, ANN INTERN MED, V124, P673, DOI 10.7326/0003-4819-124-7-199604010-00008
   LeTulzo Y, 1997, J CLIN INVEST, V99, P1516, DOI 10.1172/JCI119314
   Levenstein S, 1999, JAMA-J AM MED ASSOC, V281, P10, DOI 10.1001/jama.281.1.10
   Li Y, 2001, MICROVASC RES, V61, P253, DOI 10.1006/mvre.2001.2304
   Linden A, 1996, BRIT J PHARMACOL, V119, P402, DOI 10.1111/j.1476-5381.1996.tb16000.x
   Link AA, 2000, J IMMUNOL, V164, P436, DOI 10.4049/jimmunol.164.1.436
   Liu J, 2000, IMMUNOLOGY, V101, P61, DOI 10.1046/j.1365-2567.2000.00082.x
   LOTZ M, 1988, SCIENCE, V241, P1218, DOI 10.1126/science.2457950
   MAIMONE D, 1993, J NEUROIMMUNOL, V47, P73, DOI 10.1016/0165-5728(93)90286-8
   Marshall GD, 2000, ALLERGY ASTHMA PROC, V21, P241, DOI 10.2500/108854100778248917
   Meduri GU, 1998, CHEST, V114, P355, DOI 10.1378/chest.114.2.355-a
   Meduri GU, 1998, CRIT CARE MED, V26, P630, DOI 10.1097/00003246-199804000-00003
   Meduri GU, 2002, AM J RESP CRIT CARE, V165, P983, DOI 10.1164/ajrccm.165.7.2106014
   Meduri GU, 1999, J CHEMOTHERAPY, V11, P541, DOI 10.1179/joc.1999.11.6.541
   Metcalfe DD, 1997, PHYSIOL REV, V77, P1033, DOI 10.1152/physrev.1997.77.4.1033
   Miller LE, 2000, FASEB J, V14, P2097, DOI 10.1096/fj.99-1082com
   Minneci PC, 2004, ANN INTERN MED, V141, P47, DOI 10.7326/0003-4819-141-1-200407060-00014
   Mirani M, 2002, J IMMUNOL, V169, P6361, DOI 10.4049/jimmunol.169.11.6361
   Mohamed-Ali V, 2001, J CLIN ENDOCR METAB, V86, P5864, DOI 10.1210/jc.86.12.5864
   Mosmann TR, 1996, IMMUNOL TODAY, V17, P138, DOI 10.1016/0167-5699(96)80606-2
   Munford RS, 2002, MOL MED, V8, P437, DOI 10.1007/BF03402023
   Murray DR, 2000, CIRCULATION, V101, P2338, DOI 10.1161/01.CIR.101.20.2338
   Nakamura A, 1998, J NEUROIMMUNOL, V88, P144, DOI 10.1016/S0165-5728(98)00109-X
   Naseer T, 1997, AM J RESP CRIT CARE, V155, P845, DOI 10.1164/ajrccm.155.3.9117015
   NORRIS JG, 1993, J NEUROIMMUNOL, V45, P137
   OSULLIVAN ST, 1995, ANN SURG, V222, P482
   PaninaBordignon P, 1997, J CLIN INVEST, V100, P1513, DOI 10.1172/JCI119674
   Papanicolaou DA, 1998, ANN INTERN MED, V128, P127, DOI 10.7326/0003-4819-128-2-199801150-00009
   Perregaux DG, 2000, J IMMUNOL, V165, P4615, DOI 10.4049/jimmunol.165.8.4615
   PRABHAKAR U, 1995, INT J IMMUNOPHARMACO, V17, P221, DOI 10.1016/0192-0561(94)00096-7
   Prussin C, 2006, J ALLERGY CLIN IMMUN, V117, pS450, DOI 10.1016/j.jaci.2005.11.016
   Ramirez F, 1996, J IMMUNOL, V156, P2406
   Ricca V, 2000, J ALLERGY CLIN IMMUN, V105, P54, DOI 10.1016/S0091-6749(00)90177-5
   Rook GAW, 2002, TRENDS IMMUNOL, V23, P18, DOI 10.1016/S1471-4906(01)02090-7
   ROTHWELL PM, 1995, CRIT CARE MED, V23, P78, DOI 10.1097/00003246-199501000-00015
   Sanders VM, 1997, J IMMUNOL, V158, P4200
   Segal BM, 1998, J EXP MED, V187, P537, DOI 10.1084/jem.187.4.537
   SEVERN A, 1992, J IMMUNOL, V148, P3441
   SPENGLER RN, 1990, J IMMUNOL, V145, P1430
   STENTZ F, 2001, AM J RESP CRIT CARE, V163, pA450
   Sternberg EM, 2001, J ENDOCRINOL, V169, P429, DOI 10.1677/joe.0.1690429
   STERNBERG EM, 1989, P NATL ACAD SCI USA, V86, P2374, DOI 10.1073/pnas.86.7.2374
   STERNBERG EM, 1989, P NATL ACAD SCI USA, V86, P4771, DOI 10.1073/pnas.86.12.4771
   Straub RH, 2001, ARTHRITIS RHEUM-US, V44, P493, DOI 10.1002/1529-0131(200103)44:3<493::AID-ANR95>3.0.CO;2-U
   Strober W, 2001, ACTA ODONTOL SCAND, V59, P244, DOI 10.1080/00016350152509274
   Taylor ML, 2001, ALLERGY ASTHMA PROC, V22, P115, DOI 10.2500/108854101778148764
   Theoharides TC, 1998, ENDOCRINOLOGY, V139, P403, DOI 10.1210/en.139.1.403
   THEOHARIDES TC, 1995, ENDOCRINOLOGY, V136, P5745, DOI 10.1210/en.136.12.5745
   Tracey KJ, 2002, NATURE, V420, P853, DOI 10.1038/nature01321
   Trinchieri G, 2003, NAT REV IMMUNOL, V3, P133, DOI 10.1038/nri1001
   Van der Poll T, 1997, AM J PHYSIOL-REG I, V273, pR1885, DOI 10.1152/ajpregu.1997.273.6.R1885
   vanderPoll T, 1996, J CLIN ENDOCR METAB, V81, P3604, DOI 10.1210/jc.81.10.3604
   vanderPoll T, 1996, J CLIN INVEST, V97, P713, DOI 10.1172/JCI118469
   VANNIER E, 1991, J EXP MED, V174, P281, DOI 10.1084/jem.174.1.281
   VANNIER E, 1994, J BIOL CHEM, V269, P9952
   Vgontzas AN, 1999, J CLIN ENDOCR METAB, V84, P2603, DOI 10.1210/jc.84.8.2603
   Vgontzas AN, 1997, J CLIN ENDOCR METAB, V82, P1313, DOI 10.1210/jc.82.5.1313
   Vgontzas AN, 2002, METABOLISM, V51, P887, DOI 10.1053/meta.2002.33357
   Vgontzas AN, 2000, J CLIN ENDOCR METAB, V85, P1151, DOI 10.1210/jc.85.3.1151
   Vicennati V, 2002, INT J OBESITY, V26, P905, DOI 10.1038/sj.ijo.0802035
   von Hertzen LC, 2002, J ALLERGY CLIN IMMUN, V109, P923, DOI 10.1067/mai.2002.124776
   Wichers M, 2002, INT J NEUROPSYCHOPH, V5, P375, DOI 10.1017/S1461145702003103
   Wilder RL, 1999, ANN NY ACAD SCI, V876, P14, DOI 10.1111/j.1749-6632.1999.tb07619.x
   WILDER RL, 1995, ANNU REV IMMUNOL, V13, P307
   Wilkin F, 2002, EUR J IMMUNOL, V32, P2409, DOI 10.1002/1521-4141(200209)32:9<2409::AID-IMMU2409>3.0.CO;2-H
   Wills-Karp M, 2001, J ALLERGY CLIN IMMUN, V107, P9, DOI 10.1067/mai.2001.112265
   Woiciechowsky C, 1998, NAT MED, V4, P808, DOI 10.1038/nm0798-808
   Wong ML, 2000, P NATL ACAD SCI USA, V97, P325, DOI 10.1073/pnas.97.1.325
   Wu CY, 1998, J IMMUNOL, V161, P2723
   ZIEG G, 1994, J ALLERGY CLIN IMMUN, V94, P222, DOI 10.1016/0091-6749(94)90044-2
NR 145
TC 386
Z9 435
U1 2
U2 79
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1021-7401
EI 1423-0216
J9 NEUROIMMUNOMODULAT
JI Neuroimmunomodulation
PY 2005
VL 12
IS 5
BP 255
EP 269
DI 10.1159/000087104
PG 15
WC Endocrinology & Metabolism; Immunology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Neurosciences & Neurology
GA 964WN
UT WOS:000231911800001
PM 16166805
DA 2025-06-11
ER

PT J
AU Khanna, S
   Bishnoi, M
   Kondepudi, KK
   Shukla, G
AF Khanna, Sakshi
   Bishnoi, Mahendra
   Kondepudi, Kanthi Kiran
   Shukla, Geeta
TI Synbiotic (Lactiplantibacillus pentosus GSSK2 and
   isomalto-oligosaccharides) supplementation modulates pathophysiology and
   gut dysbiosis in experimental metabolic syndrome
SO SCIENTIFIC REPORTS
LA English
DT Article
ID HIGH-FAT DIET; MICROBIOTA; PROBIOTICS; OBESITY; MICE; ENDOTOXEMIA;
   MECHANISMS; PROTECTS; LIVER
AB Metabolic syndrome a lifestyle disease, where diet and gut microbiota play a prodigious role in its initiation and progression. Prophylactic bio-interventions employing probiotics and prebiotics offer an alternate nutritional approach towards attenuating its progression. The present study aimed to evaluate the protective efficacy of a novel synbiotic (Lactiplantibacillus pentosus GSSK2 + isomalto-oligosaccharides) in comparison to orlistat in an experimental model of metabolic syndrome. It was observed that supplementation of synbiotic for 12 weeks to Sprague Dawley rats fed with high fat diet (HFD), ameliorated the morphometric parameters i.e. weight gain, abdominal circumference, Lee's index, BMI and visceral fat deposition along with significantly increased fecal Bacteroidetes to Firmicutes ratio, elevated population of Lactobacillus spp., Akkermansia spp., Faecalibacterium spp., Roseburia spp. and decreased Enterobacteriaceae compared with HFD animals. Additionally, synbiotic administration to HFD animals exhibited improved glucose clearance, lipid biomarkers, alleviated oxidative stress, prevented leaky gut phenotype, reduced serum lipopolysaccharides and modulated the inflammatory, lipid and glucose metabolism genes along with restored histomorphology of adipose tissue, colon and liver compared with HFD animals. Taken together, the study highlights the protective potential of synbiotic in comparison with its individual components in ameliorating HFD-induced metabolic complications.
C1 [Khanna, Sakshi; Shukla, Geeta] Panjab Univ, Dept Microbiol, Basic Med Sci, Basic Med Sci Block A,South Campus, Chandigarh 160014, India.
   [Bishnoi, Mahendra; Kondepudi, Kanthi Kiran] Natl Agrifood Biotechnol Inst NABI, Food & Nutr Biotechnol Div, Hlth Gut Res Grp, Ajitgarh 140306, Punjab, India.
C3 Panjab University; Department of Biotechnology (DBT) India; National
   Agri Food Biotechnology Institute (NABI)
RP Shukla, G (corresponding author), Panjab Univ, Dept Microbiol, Basic Med Sci, Basic Med Sci Block A,South Campus, Chandigarh 160014, India.; Kondepudi, KK (corresponding author), Natl Agrifood Biotechnol Inst NABI, Food & Nutr Biotechnol Div, Hlth Gut Res Grp, Ajitgarh 140306, Punjab, India.
EM kiran@nabi.res.in; geeta_shukla@pu.ac.in
RI Bishnoi, Mahendra/CAG-3229-2022; Kondepudi, Kanthi/P-8336-2014
OI Bishnoi, Mahendra/0000-0002-7785-1204; Kondepudi, Kanthi
   Kiran/0000-0001-8036-7555
FU Indian Council of Medical Research, India [3/1/3 JRF-2016/HRD-51];
   Panjab University, Chandigarh; National Agri-Food Biotechnology
   Institute, Mohali
FX The financial support provided by the Indian Council of Medical
   Research, India (3/1/3 JRF-2016/HRD-51) for carrying the present study;
   Panjab University, Chandigarh and National Agri-Food Biotechnology
   Institute, Mohali for providing funds and research facilities are highly
   acknowledged.
CR Achari AE, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18061321
   Arora T, 2016, J INTERN MED, V280, P339, DOI 10.1111/joim.12508
   Balakumar M, 2018, EUR J NUTR, V57, P279, DOI 10.1007/s00394-016-1317-7
   Bao Y, 2012, EUR J LIPID SCI TECH, V114, P1230, DOI 10.1002/ejlt.201100393
   Boutagy NE, 2016, BIOCHIMIE, V124, P11, DOI 10.1016/j.biochi.2015.06.020
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Chandel D, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-51361-z
   Dabke K, 2019, J CLIN INVEST, V129, P4050, DOI 10.1172/JCI129194
   Davani-Davari D, 2019, FOODS, V8, DOI 10.3390/foods8030092
   ELLMAN GL, 1959, ARCH BIOCHEM BIOPHYS, V82, P70, DOI 10.1016/0003-9861(59)90090-6
   Esposito E, 2009, J NUTR, V139, P905, DOI 10.3945/jn.108.101808
   Flint HJ, 2015, P NUTR SOC, V74, P13, DOI 10.1017/S0029665114001463
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   FRINGS CS, 1970, AM J CLIN PATHOL, V53, P89
   Garg A, 2004, NEW ENGL J MED, V350, P1220, DOI 10.1056/NEJMra025261
   Gibson GR, 2017, NAT REV GASTRO HEPAT, V14, P491, DOI 10.1038/nrgastro.2017.75
   Hwang LL, 2010, OBESITY, V18, P463, DOI 10.1038/oby.2009.273
   Izquierdo AG, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112704
   Ji Y, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-43092-y
   Kang JG, 2012, DIABETES METAB J, V36, P13, DOI 10.4093/dmj.2012.36.1.13
   Ke XX, 2019, MOL METAB, V22, P96, DOI 10.1016/j.molmet.2019.01.012
   Kerry RG, 2018, J FOOD DRUG ANAL, V26, P927, DOI 10.1016/j.jfda.2018.01.002
   Khanna S, 2020, ANTON LEEUW INT J G, V113, P1345, DOI 10.1007/s10482-020-01445-y
   Khanna S, 2020, WORLD J MICROB BIOT, V36, DOI 10.1007/s11274-020-02852-z
   Kim KA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047713
   KONO Y, 1978, ARCH BIOCHEM BIOPHYS, V186, P189, DOI 10.1016/0003-9861(78)90479-4
   Li HZ, 2020, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.00512
   Li X, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01882
   Liang YJ, 2018, INFLAMMOPHARMACOLOGY, V26, P1051, DOI 10.1007/s10787-018-0479-8
   Lim SM, 2016, NUTR RES, V36, P337, DOI 10.1016/j.nutres.2015.12.001
   Liu TJ, 2020, NUTRIENTS, V12, DOI 10.3390/nu12040977
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   Martinez-Guryn K, 2018, CELL HOST MICROBE, V23, P458, DOI 10.1016/j.chom.2018.03.011
   Mennigen R, 2009, AM J PHYSIOL-GASTR L, V296, pG1140, DOI 10.1152/ajpgi.90534.2008
   Miraghajani M, 2017, SAO PAULO MED J, V135, P169, DOI 10.1590/1516-3180.2016.0311271216
   Moseti D, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17010124
   Nakamura YK, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-60
   Nido SA, 2016, BIOL TRACE ELEM RES, V171, P399, DOI 10.1007/s12011-015-0552-8
   Park SY, 2018, KOREAN J FOOD SCI AN, V38, P99, DOI 10.5851/kosfa.2018.38.1.99
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sarma SM, 2018, INT J BIOL MACROMOL, V106, P994, DOI 10.1016/j.ijbiomac.2017.08.100
   Shulman GI, 2014, NEW ENGL J MED, V371, P1131, DOI 10.1056/NEJMra1011035
   Singh DP, 2016, INT J OBESITY, V40, P487, DOI 10.1038/ijo.2015.197
   Singh DP, 2017, PHARMACOL RES, V123, P103, DOI 10.1016/j.phrs.2017.06.015
   Soundharrajan I, 2020, FASEB J, V34, P12289, DOI 10.1096/fj.202000971R
   Tamanai-Shacoori Z, 2017, FUTURE MICROBIOL, V12, P157, DOI 10.2217/fmb-2016-0130
   Tan BL, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112579
   Thiennimitr P, 2018, NUTRITION, V54, P40, DOI 10.1016/j.nut.2018.03.005
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Vallianou N, 2019, CURR OBES REP, V8, P317, DOI 10.1007/s13679-019-00352-2
   Verma A, 2014, EUR J CANCER PREV, V23, P550, DOI 10.1097/CEJ.0000000000000054
   Wang PX, 2020, CHINESE MED J-PEKING, V133, P808, DOI 10.1097/CM9.0000000000000696
   Wang Y, 2017, NUTRIENTS, V9, DOI 10.3390/nu9050521
   WILLS ED, 1966, BIOCHEM J, V99, P667, DOI 10.1042/bj0990667
   Xavier-Santos D, 2020, J FUNCT FOODS, V64, DOI 10.1016/j.jff.2019.103666
   Xu Y, 2020, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.00219
   Yadav H, 2013, J BIOL CHEM, V288, P25088, DOI 10.1074/jbc.M113.452516
   Zeng YH, 2020, J AGR FOOD CHEM, V68, P4374, DOI 10.1021/acs.jafc.0c00118
NR 58
TC 15
Z9 15
U1 4
U2 8
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD NOV 1
PY 2021
VL 11
IS 1
AR 21397
DI 10.1038/s41598-021-00601-2
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA WQ3NW
UT WOS:000713727200012
PM 34725349
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ghazimoradi, M
   Saberi-Karimian, M
   Mohammadi, F
   Sahebkar, A
   Tavallaie, S
   Safarian, H
   Ferns, GA
   Ghayour-Mobarhan, M
   Moohebati, M
   Esmaeili, H
   Ahmadinejad, M
AF Ghazimoradi, Maryam
   Saberi-Karimian, Maryam
   Mohammadi, Farzane
   Sahebkar, Amirhossein
   Tavallaie, Shima
   Safarian, Hamideh
   Ferns, Gordon A.
   Ghayour-Mobarhan, Majid
   Moohebati, Mohsen
   Esmaeili, Habibollah
   Ahmadinejad, Malihe
TI The Effects of Curcumin and Curcumin-Phospholipid Complex on the Serum
   Pro-oxidant-Antioxidant Balance in Subjects with Metabolic Syndrome
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE metabolic syndrome; curcumin; pro-oxidant-antioxidant balance
ID RANDOMIZED CONTROLLED-TRIAL; OXIDATIVE STRESS; OBESE INDIVIDUALS;
   DISEASE; PROOXIDANT; CHEMISTRY; AGENT; CELLS
AB Metabolic syndrome (MetS) is defined by a clustering of metabolic and anthropometric abnormalities and is associated by an increased risk of cardiovascular disease. We have investigated the effect of curcumin supplementation on the serum pro-oxidant-antioxidant balance (PAB) in patients with MetS. This double-blind, randomized, placebo-controlled trial was conducted over 6weeks. Subjects (n=120) were randomly allocated to one of three groups (curcumin, phospholipidated curcumin, and placebo). The curcumin group received 1g/day of simple curcumin, the phospholipidated curcumin group received 1g/day of phospholipidated curcumin (containing 200mg of pure curcumin), and the control group received 1g/day of placebo. Serum PAB was measured before and after the intervention (at baseline and at 6weeks). Data analyses were performed using spss software (version 16.0). Serum PAB increased significantly in the curcumin group (p<0.001), but in the phospholipidated curcumin group, elevation of PAB level was not significant (p=0.053). The results of our study did not suggest any improvement of PAB following supplementation with curcumin in MetS subjects. Copyright (c) 2017 John Wiley & Sons, Ltd.
C1 [Ghazimoradi, Maryam; Mohammadi, Farzane; Tavallaie, Shima; Safarian, Hamideh; Ghayour-Mobarhan, Majid; Esmaeili, Habibollah; Ahmadinejad, Malihe] Mashhad Univ Med Sci, Sch Med, Metab Syndrome Res Ctr, Mashhad, Iran.
   [Saberi-Karimian, Maryam] Mashhad Univ Med Sci, Sch Med, Dept Modern Sci & Technol, Student Res Comm, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Biotechnol Res Ctr, Mashhad, Iran.
   [Ferns, Gordon A.] Brighton & Sussex Med Sch, Div Med Educ, Brighton BN1 9PH, E Sussex, England.
   [Ghayour-Mobarhan, Majid; Moohebati, Mohsen] Mashhad Univ Med Sci, Sch Med, Cardiovasc Res Ctr, Mashhad, Iran.
   [Esmaeili, Habibollah] Mashhad Univ Med Sci, Sch Hlth, Dept Biostat, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; University of Sussex;
   University of Brighton; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences
RP Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Sch Med, Metab Syndrome Res Ctr, Mashhad, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Med, Dept Biotechnol, Mashhad, Iran.
EM sahebkara@mums.ac.ir; ghayourm@mums.ac.ir
RI Ghayour-Mobarhan, Majid/AAY-5963-2020; mohebati, mohsen/AAR-2016-2021;
   ebrahimi, mansour/D-9950-2011; Sahebkar, Amirhossein/B-5124-2018;
   Esmaily, Habibollah/N-8264-2016; Mohammadi, Farzaneh/IYJ-7537-2023
OI Esmaily, Habibollah/0000-0003-4139-546X; Mohammadi,
   Farzaneh/0000-0002-0088-4729
FU Mashhad University of Medical Sciences
FX This research is financially supported by the Mashhad University of
   Medical Sciences.
CR Ahsan H, 1999, CHEM-BIOL INTERACT, V121, P161, DOI 10.1016/S0009-2797(99)00096-4
   Akaberi M, 2016, PHYTOTHER RES, V30, P540, DOI 10.1002/ptr.5570
   Alamdari DH, 2008, CLIN BIOCHEM, V41, P375, DOI 10.1016/j.clinbiochem.2007.12.008
   Alamdari DH, 2009, IRAN J BASIC MED SCI, V12, P93
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Ashok BT, 1999, EXP GERONTOL, V34, P293, DOI 10.1016/S0531-5565(99)00005-4
   Azizi F, 2010, ARCH IRAN MED, V13, P426, DOI 010135/AIM.0011
   Bachmeier Beatrice E, 2010, Front Biosci (Schol Ed), V2, P697
   Banerjee A, 2008, CHEM-BIOL INTERACT, V174, P134, DOI 10.1016/j.cbi.2008.05.009
   Belcaro G, 2010, ALTERN MED REV, V15, P337
   Bhaumik S, 1999, FEBS LETT, V456, P311, DOI 10.1016/S0014-5793(99)00969-2
   Cameron AJ, 2004, ENDOCRIN METAB CLIN, V33, P351, DOI 10.1016/j.ecl.2004.03.005
   Cherniack EP, 2011, NUTRITION, V27, P617, DOI 10.1016/j.nut.2010.10.013
   Esmaily H, 2015, CHIN J INTEGR MED, V21, P332, DOI 10.1007/s11655-015-2160-z
   Hildrum B, 2007, BMC PUBLIC HEALTH, V7, DOI 10.1186/1471-2458-7-220
   Hopps E, 2010, NUTR METAB CARDIOVAS, V20, P72, DOI 10.1016/j.numecd.2009.06.002
   Kunnumakkara AB, 2017, BRIT J PHARMACOL, V174, P1325, DOI 10.1111/bph.13621
   Maheshwari RK, 2006, LIFE SCI, V78, P2081, DOI 10.1016/j.lfs.2005.12.007
   Milani A, 2017, BRIT J PHARMACOL, V174, P1290, DOI 10.1111/bph.13625
   Mohammadi A, 2013, PHYTOTHER RES, V27, P374, DOI 10.1002/ptr.4715
   Motterlini R, 2000, FREE RADICAL BIO MED, V28, P1303, DOI 10.1016/S0891-5849(00)00294-X
   Nelson KM, 2017, J MED CHEM, V60, P1620, DOI 10.1021/acs.jmedchem.6b00975
   Panahi Y, 2017, INFLAMMOPHARMACOLOGY, V25, P25, DOI 10.1007/s10787-016-0301-4
   Panahi Y, 2015, CLIN NUTR, V34, P1101, DOI 10.1016/j.clnu.2014.12.019
   Prasad S, 2014, CANCER RES TREAT, V46, P2, DOI 10.4143/crt.2014.46.1.2
   Priyadarsini KI, 2014, MOLECULES, V19, P20091, DOI 10.3390/molecules191220091
   Rahmani S, 2016, PHYTOTHER RES, V30, P1540, DOI 10.1002/ptr.5659
   Rahsepar AA, 2012, ANGIOLOGY, V63, P609, DOI 10.1177/0003319711433308
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   RUBY AJ, 1995, CANCER LETT, V94, P79, DOI 10.1016/0304-3835(95)03827-J
   Sadeghnia HR, 2013, IRAN J BASIC MED SCI, V16, P73
   Sahebkar A, 2013, PHYTOTHER RES, V27, P1883, DOI 10.1002/ptr.4952
   Samuhasaneeto S, 2009, J BIOMED BIOTECHNOL, DOI 10.1155/2009/981963
   Scapagnini G, 2006, ANTIOXID REDOX SIGN, V8, P395, DOI 10.1089/ars.2006.8.395
   Semalty A, 2010, FITOTERAPIA, V81, P306, DOI 10.1016/j.fitote.2009.11.001
   Wongcharoen W, 2009, INT J CARDIOL, V133, P145, DOI 10.1016/j.ijcard.2009.01.073
NR 37
TC 27
Z9 29
U1 1
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD NOV
PY 2017
VL 31
IS 11
BP 1715
EP 1721
DI 10.1002/ptr.5899
PG 7
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FL9GV
UT WOS:000414562300009
PM 28840615
OA Bronze
DA 2025-06-11
ER

PT J
AU Wong, SK
   Chin, KY
   Suhaimi, FH
   Ahmad, F
   Ima-Nirwana, S
AF Wong, Sok Kuan
   Chin, Kok-Yong
   Suhaimi, Farihah Hj
   Ahmad, Fairus
   Ima-Nirwana, Soelaiman
TI Vitamin E As a Potential Interventional Treatment for Metabolic
   Syndrome: Evidence from Animal and Human Studies
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE vitamin E; tocopherol; tocotrienol; metabolic syndrome; obesity;
   hyperglycemia; hypertension; dyslipidemia
ID RICE BRAN OIL; ALPHA-TOCOPHEROL; OXIDATIVE STRESS; ANTIOXIDANT
   PROPERTIES; DOUBLE-BLIND; LIPID PARAMETERS; FRACTION SUPPLEMENTATION;
   INDUCED NEPHROPATHY; INSULIN-RESISTANCE; DELTA-TOCOTRIENOL
AB A constellation of medical conditions inclusive of central obesity, hyperglycemia, hypertension, and dyslipidemia is known as metabolic syndrome (MetS). The safest option in curtailing the progression of MetS is through maintaining a healthy lifestyle, which by itself, is a long-term commitment entailing much determination. A combination of pharmacological and non-pharmacological approach, as well as lifestyle modification is a more holistic alternative in the management of MetS. Vitamin E has been revealed to possess anti-oxidative, anti-inflammatory, anti-obesity, anti-hyperglycemic, anti-hypertensive and anti-hypercholesterolemic properties. The pathways regulated by vitamin E are critical in the development of MetS and its components. Therefore, we postulate that vitamin E may exert some health benefits on MetS patients. This review intends to summarize the evidence in animal and human studies on the effects of vitamin E and articulate the contrasting potential of tocopherol (TF) and tocotrienol (T3) in preventing the medical conditions associated with MetS. As a conclusion, this review suggests that vitamin E may be a promising agent for attenuating MetS.
C1 [Wong, Sok Kuan; Chin, Kok-Yong; Ima-Nirwana, Soelaiman] Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Cheras, Malaysia.
   [Suhaimi, Farihah Hj; Ahmad, Fairus] Univ Kebangsaan Malaysia, Fac Med, Dept Anat, Cheras, Malaysia.
C3 Universiti Kebangsaan Malaysia; Universiti Kebangsaan Malaysia
RP Ima-Nirwana, S (corresponding author), Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Cheras, Malaysia.
EM imasoel@ppukm.ukm.edu.my
RI Soelaiman, Ima/C-4289-2017; Chin, Kok-Yong/B-6309-2015; Wong, Sok
   Kuan/I-1243-2016
OI Ahmad, Fairus/0000-0002-2452-6459; Chin, Kok-Yong/0000-0001-6628-1552;
   Wong, Sok Kuan/0000-0003-1184-4551
FU Universiti Kebangsaan Malaysia via High Impact Research Grant
   [DIP-2014-040]; PPUKM Fundamental Grant [FF-2016-431]
FX We thank Universiti Kebangsaan Malaysia for funding the studies via High
   Impact Research Grant (DIP-2014-040) and PPUKM Fundamental Grant
   (FF-2016-431).
CR Aasheim ET, 2008, AM J CLIN NUTR, V87, P362, DOI 10.1093/ajcn/87.2.362
   Aggarwal BB, 2010, BIOCHEM PHARMACOL, V80, P1613, DOI 10.1016/j.bcp.2010.07.043
   Alcalá M, 2015, OBESITY, V23, P1598, DOI 10.1002/oby.21135
   Allen PS, 2015, NUTR DIET SUPPL, V7, P77, DOI 10.2147/NDS.S88888
   [Anonymous], 2000, Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids
   Asai A, 1999, BIOSCI BIOTECH BIOCH, V63, P2118, DOI 10.1271/bbb.63.2118
   Baliarsingh S, 2005, ATHEROSCLEROSIS, V182, P367, DOI 10.1016/j.atherosclerosis.2005.02.020
   Baradaran A, 2014, J RES MED SCI, V19, P358
   Boudreau DM, 2009, METAB SYNDR RELAT D, V7, P305, DOI 10.1089/met.2008.0070
   Brigelius-Flohé R, 1999, FASEB J, V13, P1145, DOI 10.1096/fasebj.13.10.1145
   Budin SB, 2009, CLINICS, V64, P235, DOI 10.1590/S1807-59322009000300015
   Burdeos GC, 2012, LIPIDS, V47, P471, DOI 10.1007/s11745-012-3659-0
   Chin SF, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-42
   Chou TW, 2009, J CLIN BIOCHEM NUTR, V45, P29, DOI 10.3164/jcbn.08-257
   Daud ZAM, 2013, VASC HEALTH RISK MAN, V9, P747, DOI 10.2147/VHRM.S51710
   Devaraj S, 2008, FREE RADICAL BIO MED, V44, P1203, DOI 10.1016/j.freeradbiomed.2007.12.018
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Engin KN, 2009, MOL VIS, V15, P855
   Evans HM, 1922, SCIENCE, V56, P650, DOI 10.1126/science.56.1458.650
   Fang F, 2010, MOL NUTR FOOD RES, V54, P345, DOI 10.1002/mnfr.200900119
   Gonzalez Y, 2012, BMC IMMUNOL, V13, DOI 10.1186/1471-2172-13-19
   Haghighat N, 2014, INT J PREVENTIVE MED, V5, P617
   Han TS, 2016, JRSM CARDIOVASC DIS, V5, DOI 10.1177/2048004016633371
   Hasty AH, 2007, J NUTR BIOCHEM, V18, P127, DOI 10.1016/j.jnutbio.2006.03.012
   Heng K. S., 2015, Malaysian Journal of Nutrition, V21, P231
   Hosomi A, 1997, FEBS LETT, V409, P105, DOI 10.1016/S0014-5793(97)00499-7
   Iqbal J, 2003, EUR J CANCER PREV, V12, P447, DOI 10.1097/00008469-200312000-00002
   Irandoost P, 2013, INT J FOOD SCI NUTR, V64, P706, DOI 10.3109/09637486.2013.775228
   Jain AB, 2012, J CLIN DIAGN RES, V6, P1624, DOI 10.7860/JCDR/2012/4791.2625
   Johnson P, 2015, WORKPLACE HEALTH SAF, V63, P245, DOI 10.1177/2165079915576920
   KamalEldin A, 1996, LIPIDS, V31, P671, DOI 10.1007/BF02522884
   Karmali S, 2010, CAN FAM PHYSICIAN, V56, P873
   Kataja-Tuomola MK, 2011, EUR J CLIN NUTR, V65, P590, DOI 10.1038/ejcn.2010.283
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Khan MS, 2011, PHYTOTHER RES, V25, P1586, DOI 10.1002/ptr.3448
   Khor HT, 2000, INT J FOOD SCI NUTR, V51, pS3, DOI 10.1080/096374800750049521
   Kuhad A, 2009, NEUROPHARMACOLOGY, V57, P456, DOI 10.1016/j.neuropharm.2009.06.013
   Kuhad A, 2009, PHARMACOL BIOCHEM BE, V92, P251, DOI 10.1016/j.pbb.2008.12.012
   Kuhad A, 2009, LIFE SCI, V84, P296, DOI 10.1016/j.lfs.2008.12.014
   Levine S., 2008, FOCUS NUTRICOLOGY NE, P2
   Mah E, 2015, AM J CLIN NUTR, V102, P1070, DOI 10.3945/ajcn.115.118570
   Mahdy Zaleha Abdullah, 2013, Acta Medica (Hradec Kralove), V56, P104
   Matough Fatmah A, 2014, Sultan Qaboos Univ Med J, V14, pe95
   Minhajuddin M, 2005, FOOD CHEM TOXICOL, V43, P747, DOI 10.1016/j.fct.2005.01.015
   Miyamoto K, 2009, J NEUROSCI RES, V87, P556, DOI 10.1002/jnr.21851
   Montezano AC, 2012, ANN MED, V44, pS2, DOI 10.3109/07853890.2011.653393
   Montonen J, 2004, DIABETES CARE, V27, P362, DOI 10.2337/diacare.27.2.362
   Mustad VA, 2002, AM J CLIN NUTR, V76, P1237, DOI 10.1093/ajcn/76.6.1237
   Newaz MA, 2003, J PHYSIOL PHARMACOL, V54, P319
   O'Byrne D, 2000, FREE RADICAL BIO MED, V29, P834, DOI 10.1016/S0891-5849(00)00371-3
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Pazdro R, 2010, MECH AGEING DEV, V131, P276, DOI 10.1016/j.mad.2010.03.005
   Qureshi A.A., 2015, J Clin Exp Cardiol, V6, DOI [10.4172/2155-9880.1000411, DOI 10.4172/2155-9880.1000411]
   Qureshi AA, 2002, ATHEROSCLEROSIS, V161, P199, DOI 10.1016/S0021-9150(01)00619-0
   Qureshi AA, 2001, J NUTR BIOCHEM, V12, P318, DOI 10.1016/S0955-2863(01)00144-9
   Qureshi AA, 2001, ATHEROSCLEROSIS, V156, P39, DOI 10.1016/S0021-9150(00)00612-2
   Qureshi AA, 2001, J NUTR, V131, P223, DOI 10.1093/jn/131.2.223
   QURESHI AA, 1986, J BIOL CHEM, V261, P544
   Qureshi AA, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-39
   Raederstorff D, 2002, ANN NUTR METAB, V46, P17, DOI 10.1159/000046748
   Rasool AHG, 2006, J NUTR SCI VITAMINOL, V52, P473, DOI 10.3177/jnsv.52.473
   Rodrigo R, 2011, HYPERTENS RES, V34, P431, DOI 10.1038/hr.2010.264
   Sen CK, 2006, LIFE SCI, V78, P2088, DOI 10.1016/j.lfs.2005.12.001
   SERBINOVA E, 1991, FREE RADICAL BIO MED, V10, P263, DOI 10.1016/0891-5849(91)90033-Y
   SERBINOVA EA, 1994, METHOD ENZYMOL, V234, P354
   Shibata A, 2016, J AGR FOOD CHEM, V64, P5361, DOI 10.1021/acs.jafc.6b02228
   Shibata A, 2010, BIOCHEM BIOPH RES CO, V397, P214, DOI 10.1016/j.bbrc.2010.05.087
   Siddiqui S, 2013, TOXICOL APPL PHARM, V273, P314, DOI 10.1016/j.taap.2013.09.004
   Siddiqui S, 2010, CHEM-BIOL INTERACT, V188, P651, DOI 10.1016/j.cbi.2010.08.010
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   SUNDRAM K, 1989, CANCER RES, V49, P1447
   Traber MG, 2014, ADV NUTR, V5, P503, DOI 10.3945/an.114.006254
   Uchida T, 2012, LIPIDS, V47, P129, DOI 10.1007/s11745-011-3620-7
   Vafa M, 2015, J RES MED SCI, V20, P540, DOI 10.4103/1735-1995.165945
   Ward NC, 2007, J HYPERTENS, V25, P227, DOI 10.1097/01.hjh.0000254373.96111.43
   Weng-Yew W, 2011, CURR PHARM DESIGN, V17, P2206, DOI 10.2174/138161211796957445
   Wong SK, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0123-9
   Wong SK, 2016, NUTRIENTS, V8, DOI 10.3390/nu8060347
   Wong WY, 2017, EUR J NUTR, V56, P133, DOI 10.1007/s00394-015-1064-1
   Wong WY, 2012, NUTRIENTS, V4, P1527, DOI 10.3390/nu4101527
   Wu JHY, 2007, CLIN CHEM, V53, P511, DOI 10.1373/clinchem.2006.076992
   Yu SG, 2006, LIPIDS, V41, P453, DOI 10.1007/s11745-006-5119-1
   Zaiden N, 2010, J ATHEROSCLER THROMB, V17, P1019, DOI 10.5551/jat.4911
   Zhao L, 2015, INT J OBESITY, V39, P438, DOI 10.1038/ijo.2014.124
NR 84
TC 89
Z9 90
U1 0
U2 23
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JUL 5
PY 2017
VL 8
AR 444
DI 10.3389/fphar.2017.00444
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FB5CW
UT WOS:000406160100001
PM 28725195
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Fahmy, MIM
   Sayed, RH
   El-Yamany, MF
   El-Naggar, R
   Eliwa, HA
AF Fahmy, Mohamed Ibrahim Mohamed
   Sayed, Rabab Hamed
   El-Yamany, Muhammad Farag
   El-Naggar, Reham
   Eliwa, Hesham A.
TI Rosuvastatin and co-enzyme Q10 improve high-fat and
   high-fructose diet-induced metabolic syndrome in rats via ameliorating
   inflammatory and oxidative burden
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Metabolic syndrome; Rosuvastatin; Co-enzyme Q10; HF-HFD; Oxidative
   stress; Inflammation
ID LOW-DENSITY-LIPOPROTEIN; STATIN-ASSOCIATED MYOPATHY; INSULIN-RESISTANCE;
   BLOOD-PRESSURE; MITOCHONDRIAL DYSFUNCTION; GLUCOSE-METABOLISM; GLYCEMIC
   CONTROL; SKELETAL-MUSCLE; LIVER-DISEASE; ANTIOXIDANT
AB The prevalence of metabolic syndrome (MetS) has been rising alarmingly and it has now become a global concern causing an enormous economic burden on the health care system. MetS is generally linked to complications in lipid metabolism, oxidative stress and low grade inflammation. The aim of the current study was to evaluate the effect of rosuvastatin, co-enzyme Q10 (CoQ10), and their combination on blood pressure, blood sugar, dyslipidemia, and liver function in rats with MetS induced by high fructose and high fat diet (HF-HFD) and the possible underlying mechanism. Oral administration of rosuvastatin (10 mg/kg/day), CoQ10 (10 mg/kg/ day) and their combination for 4 weeks in HF-HFD-fed rats elevated serum high density lipoprotein and reduced glutathione. On the other hand, treatment with rosuvastatin, CoQ10 or their combination decreased the serum levels of malondialdehyde, triglycerides, total cholesterol, and low density lipoprotein-cholesterol as well as systolic blood pressure, body weight and fasting blood glucose level. In addition, the drugs or their combination declined serum pro-inflammatory cytokines, namely tumor necrosis factor-alpha and interleukin-1 beta. In conclusion, our results showed that rosuvastatin or CoQ10 protected against HF-HFD-induced MetS through the regulation of dyslipidemia, elevated blood glucose, elevated blood pressure, antioxidant defenses and inflammatory response. Rosuvastatin or CoQ10 also alleviated the impairment of liver function that was induced by HF-HFD. Interestingly, CoQ10 augmented msuvastatin's effect in ameliorating MetS, via exerting synergistic modulatory effects on oxidative stress and inflammation. Thus, rosuvastatin and CoQ10 combination therapy may have possible applications in ameliorating metabolic disorders.
C1 [Fahmy, Mohamed Ibrahim Mohamed] Heliopolis Univ Sustainable Dev, Fac Pharm, Dept Pharmacol & Toxicol, Cairo, Egypt.
   [Sayed, Rabab Hamed; El-Yamany, Muhammad Farag] Cairo Univ, Fac Pharm, Dept Pharmacol & Toxicol, Giza, Egypt.
   [El-Naggar, Reham; Eliwa, Hesham A.] Misr Univ Sci & Technol MUST, Fac Pharm, Dept Pharmacol & Toxicol, Giza, Egypt.
C3 Egyptian Knowledge Bank (EKB); Heliopolis University; Egyptian Knowledge
   Bank (EKB); Cairo University; Egyptian Knowledge Bank (EKB); Misr
   University for Science & Technology
RP Sayed, RH (corresponding author), Fac Pharm, Kasr El Aini St, Cairo 11562, Egypt.
EM rabab.sayed@pharma.cu.edu.eg
RI , Rabab/I-2381-2019
OI , Rabab/0000-0002-5337-3658
CR Abbas A, 2012, CLIN MED INSIGHTS-EN, V5, P13, DOI 10.4137/CMED.S7591
   Abdelbaset M., 2014, CAN J PHYSIOL PHARM, V9, P1
   Alam MA, 2014, J DIABETES METAB DIS, V13, DOI 10.1186/2251-6581-13-60
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Annani-Akollor ME, 2019, DIABETOL METAB SYNDR, V11, DOI 10.1186/s13098-019-0423-0
   Ansari JA, 2012, TOXICOL MECH METHOD, V22, P67, DOI 10.3109/15376516.2011.603391
   Jiménez-Santos MA, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-22
   Argo CK, 2008, HEPATOLOGY, V48, P662, DOI 10.1002/hep.22402
   Bantle JP, 2009, J NUTR, V139, pS1263, DOI 10.3945/jn.108.098020
   BERGMEYER HU, 1978, CLIN CHEM, V24, P58
   Bessler H, 2010, J NUTR SCI VITAMINOL, V56, P77, DOI 10.3177/jnsv.56.77
   BEUTLER E, 1963, J LAB CLIN MED, V61, P882
   Bezerra RMN, 2001, BRAZ J MED BIOL RES, V34, P1155, DOI 10.1590/S0100-879X2001000900008
   Bhagavan HN, 2006, FREE RADICAL RES, V40, P445, DOI 10.1080/10715760600617843
   Brito JO, 2008, BRAZ J MED BIOL RES, V41, P804, DOI 10.1590/S0100-879X2008005000030
   Buckley AJ, 2018, DIABETES RES CLIN PR, V144, P144, DOI 10.1016/j.diabres.2018.08.011
   BURSTEIN M, 1970, EUR J CLIN BIOL RES, V15, P109
   Buse J., 2003, CLIN DIABETES, V21, P168, DOI DOI 10.2337/DIACLIN.21.4.168
   Chandramohan R., 2014, BIOMED AGING PATHOL, V4, P23, DOI [10.1016/j.biomag.2013.12.003, DOI 10.1016/J.BIOMAG.2013.12.003]
   Chang SH, 2016, AM J NURS, V116, P26, DOI 10.1097/01.NAJ.0000508662.88220.7a
   Cooke M, 2008, J INT SOC SPORT NUTR, V5, DOI 10.1186/1550-2783-5-8
   Crescenzo R, 2014, EXP PHYSIOL, V99, P1203, DOI 10.1113/expphysiol.2014.079632
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   Desjardins F, 2008, EUR HEART J, V29, P128, DOI 10.1093/eurheartj/ehm540
   Di Stasi SL, 2010, PHYS THER, V90, P1530, DOI 10.2522/ptj.20090251
   Duarte T, 2016, PHARMACOGENOMICS J, V16, P501, DOI 10.1038/tpj.2015.91
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Ekstedt M, 2006, HEPATOLOGY, V44, P865, DOI 10.1002/hep.21327
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   Fedacko J, 2013, CAN J PHYSIOL PHARM, V91, P165, DOI 10.1139/cjpp-2012-0118
   FOSSATI P, 1982, CLIN CHEM, V28, P2077
   Fouad AA, 2012, ENVIRON TOXICOL PHAR, V33, P158, DOI 10.1016/j.etap.2011.12.011
   Freeman DJ, 2001, CIRCULATION, V103, P357
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Fu FY, 2016, EUR REV MED PHARMACO, V20, P2368
   Galley HF, 2011, BRIT J ANAESTH, V107, P57, DOI 10.1093/bja/aer093
   Grosser N, 2004, BIOCHEM BIOPH RES CO, V325, P871, DOI 10.1016/j.bbrc.2004.10.123
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Guerin M, 2002, ATHEROSCLEROSIS, V163, P287, DOI 10.1016/S0021-9150(02)00037-0
   Hargreaves IP, 2005, DRUG SAFETY, V28, P659, DOI 10.2165/00002018-200528080-00002
   Henriksen JE, 1999, DIABETIC MED, V16, P312, DOI 10.1046/j.1464-5491.1999.00064.x
   Hodgson JM, 2002, EUR J CLIN NUTR, V56, P1137, DOI 10.1038/sj.ejcn.1601464
   Holvoet P, 2008, JAMA-J AM MED ASSOC, V299, P2287, DOI 10.1001/jama.299.19.2287
   Horvath R, 2012, J INHERIT METAB DIS, V35, P679, DOI 10.1007/s10545-011-9434-1
   Huptas S, 2006, AM J CARDIOL, V98, P66, DOI 10.1016/j.amjcard.2006.01.055
   Jalal DI, 2010, J AM SOC NEPHROL, V21, P1543, DOI 10.1681/ASN.2009111111
   Jones PH, 2003, AM J CARDIOL, V92, P152, DOI 10.1016/S0002-9149(03)00530-7
   Kendrach MG, 2004, ANN PHARMACOTHER, V38, P1286, DOI 10.1345/aph.1D391
   Kostapanos MS, 2008, EUR J PHARMACOL, V590, P327, DOI 10.1016/j.ejphar.2008.06.007
   Kumar A, 2009, PHARMACOL THERAPEUT, V124, P259, DOI 10.1016/j.pharmthera.2009.07.003
   Kyaw T, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0060430
   Lalli CA, 2008, METABOLISM, V57, P57, DOI 10.1016/j.metabol.2007.07.021
   Lazzerini PE, 2013, JOINT BONE SPINE, V80, P195, DOI 10.1016/j.jbspin.2012.07.007
   Lee BJ, 2012, NUTRITION, V28, P767, DOI 10.1016/j.nut.2011.11.008
   Liao JK, 2005, ANNU REV PHARMACOL, V45, P89, DOI 10.1146/annurev.pharmtox.45.120403.095748
   Mahalwar R, 2013, EUR J PHARMACOL, V711, P57, DOI 10.1016/j.ejphar.2013.04.025
   Maladkar M., 2016, CARDIOVASC THER, V1
   Mendizábal Y, 2013, INT J HYPERTENS, V2013, DOI 10.1155/2013/230868
   Miersch S, 2007, FREE RADICAL BIO MED, V42, P270, DOI 10.1016/j.freeradbiomed.2006.10.045
   Modi K, 2006, BIOL TRACE ELEM RES, V109, P25, DOI 10.1385/BTER:109:1:025
   Mohaupt MG, 2009, CAN MED ASSOC J, V181, pE11, DOI 10.1503/cmaj.081785
   Mora S, 2012, J AM COLL CARDIOL, V59, P1521, DOI 10.1016/j.jacc.2011.12.035
   Naples M, 2008, ATHEROSCLEROSIS, V198, P94, DOI 10.1016/j.atherosclerosis.2007.11.003
   OKAMOTO H, 1991, BIOCHEM MED METAB B, V45, P216, DOI 10.1016/0885-4505(91)90024-F
   Panchal SK, 2011, J BIOMED BIOTECHNOL, DOI 10.1155/2011/351982
   Paolisso G, 2000, ATHEROSCLEROSIS, V150, P121, DOI 10.1016/S0021-9150(99)00352-4
   Potgieter M, 2013, NUTR REV, V71, P180, DOI 10.1111/nure.12011
   REITMAN S, 1957, AM J CLIN PATHOL, V28, P56, DOI 10.1093/ajcp/28.1.56
   RICHMOND W, 1973, CLIN CHEM, V19, P1350
   Rocha V.N., 2014, ENDOCRINOL METAB SYN, V3, P1, DOI [10.4172/2161-1017.1000121, DOI 10.4172/2161-1017.1000121]
   Rosenfeldt FL, 2007, J HUM HYPERTENS, V21, P297, DOI 10.1038/sj.jhh.1002138
   Rozman D, 2010, PHARMACOL THERAPEUT, V127, P19, DOI 10.1016/j.pharmthera.2010.03.007
   Rubba P, 2009, VASC HEALTH RISK MAN, V5, P343
   Schroeder MM, 2005, IMMUNOPHARM IMMUNOT, V27, P109, DOI 10.1081/IPH-200051755
   Seo DC, 2017, PREV MED, V97, P100, DOI 10.1016/j.ypmed.2017.01.012
   Sigit FS, 2020, DIABETOL METAB SYNDR, V12, DOI 10.1186/s13098-019-0503-1
   Singh RB, 2000, ATHEROSCLEROSIS, V148, P275, DOI 10.1016/S0021-9150(99)00273-7
   Stalker TJ, 2001, BRIT J PHARMACOL, V133, P406, DOI 10.1038/sj.bjp.0704070
   STOCKER R, 1991, P NATL ACAD SCI USA, V88, P1646, DOI 10.1073/pnas.88.5.1646
   Storlien LH, 2000, BRIT J NUTR, V83, pS85
   Sun YM, 2010, PEPTIDES, V31, P1205, DOI 10.1016/j.peptides.2010.03.023
   SZASZ G, 1976, CLIN CHEM, V22, P650
   Tappy L, 2018, J EXP BIOL, V221, DOI 10.1242/jeb.164202
   Tilg H, 2006, GASTROENTEROLOGY, V131, P934, DOI 10.1053/j.gastro.2006.05.054
   Totsuka M, 2002, J APPL PHYSIOL, V93, P1280, DOI 10.1152/japplphysiol.01270.2001
   Trinder P., 1969, ANN CLIN BIOCHEM, V6, P24, DOI 10.1177/000456326900600108
   UCHIYAMA M, 1978, ANAL BIOCHEM, V86, P271, DOI 10.1016/0003-2697(78)90342-1
   Victor VM, 2009, CURR MED CHEM, V16, P4654, DOI 10.2174/092986709789878265
   Wilson PWF, 2005, CIRCULATION, V112, P3066, DOI 10.1161/CIRCULATIONAHA.105.539528
   Yamagishi S, 2007, INT J CARDIOL, V118, P270, DOI 10.1016/j.ijcard.2006.06.058
NR 90
TC 4
Z9 4
U1 1
U2 5
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD SEP
PY 2022
VL 153
AR 113526
DI 10.1016/j.biopha.2022.113526
EA AUG 2022
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 5J7KR
UT WOS:000869218700003
PM 36076607
OA gold
DA 2025-06-11
ER

PT J
AU Murase, T
   Hattori, T
   Ohtake, M
   Abe, M
   Amakusa, Y
   Takatsu, M
   Murohara, T
   Nagata, K
AF Murase, Tamayo
   Hattori, Takuya
   Ohtake, Masafumi
   Abe, Mayuna
   Amakusa, Yui
   Takatsu, Miwa
   Murohara, Toyoaki
   Nagata, Kohzo
TI Cardiac remodeling and diastolic dysfunction in
   DahlS.Z-Lepr<SUP>fa</SUP>/Lepr<SUP>fa</SUP> rats: a
   new animal model of metabolic syndrome
SO HYPERTENSION RESEARCH
LA English
DT Article
DE cardiac hypertrophy; diastolic dysfunction; metabolic syndrome;
   myocardial fibrosis; salt-sensitive hypertension
ID NECROSIS-FACTOR-ALPHA; SALT-SENSITIVE HYPERTENSION; HEART-FAILURE;
   OXIDATIVE STRESS; NADPH OXIDASE; II LEVELS; ACTIVATION; OBESITY;
   HYPERTROPHY; INFLAMMATION
AB We recently characterized male DahlS. Z-Lepr(fa)/Lepr(fa) (Dahl salt-sensitive (DS)/obese) rats, which were established from a cross between Dahl salt-sensitive and Zucker rats, as a new animal model of metabolic syndrome (MetS). We have now investigated cardiac pathophysiology and metabolic changes in female DS/obese rats in comparison with homozygous lean female littermates (DahlS. Z-Lepr(+)/Lepr(+), or DS/lean, rats). Animals were maintained on a normal diet and were subjected to echocardiography followed by various pathological analyses at 15 weeks of age. Systolic blood pressure was significantly higher in female DS/obese rats than in DS/lean females at 12 weeks of age and thereafter. The survival rate of DS/obese rats was significantly lower than that of DS/lean rats at 15 weeks. Body weight, as well as visceral and subcutaneous fat mass were significantly increased in DS/obese rats, which also manifested left ventricular (LV) diastolic dysfunction and marked LV hypertrophy and fibrosis. In addition, myocardial oxidative stress and inflammation were increased in DS/obese rats compared with DS/lean rats. Serum insulin and triglyceride levels as well as the ratio of low-density lipoprotein-to high-density lipoprotein-cholesterol levels were markedly elevated in DS/obese rats, whereas fasting serum glucose concentrations were similar in the two rat strains. The phenotype of female DS/obese rats is similar to that of MetS in humans. These animals also develop salt-sensitive hypertension and LV diastolic dysfunction as well as LV hypertrophy and fibrosis, and these changes are associated with increased cardiac oxidative stress and inflammation. Hypertension Research (2012) 35, 186-193; doi:10.1038/hr.2011.157; published online 15 September 2011
C1 [Nagata, Kohzo] Nagoya Univ, Dept Med Technol, Sch Hlth Sci, Higashi Ku, Nagoya, Aichi 4618673, Japan.
   [Murase, Tamayo; Hattori, Takuya; Ohtake, Masafumi; Takatsu, Miwa] Univ Grad Sch Med, Dept Pathophysiol Lab Sci, Nagoya, Aichi, Japan.
   [Murohara, Toyoaki] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi 4618673, Japan.
C3 Nagoya University; Nagoya University
RP Nagata, K (corresponding author), Nagoya Univ, Dept Med Technol, Sch Hlth Sci, Higashi Ku, 1-1-20 Daikominami, Nagoya, Aichi 4618673, Japan.
EM nagata@met.nagoya-u.ac.jp
RI Murohara, Toyoaki/M-4958-2014
FU Mitsubishi Tanabe Pharma Corp. (Osaka, Japan); Kyowa Hakko Kirin Co Ltd
   (Tokyo, Japan); Japanese government
FX We thank Mayuko Furukawa, Koji Tsuboi, Yuichiro Yamada, Chisa Inoue,
   Tomomi Inoue, Haruka Tsukamoto, Masafumi Sakai and Chieko Nakashima for
   technical assistance. This work was supported by unrestricted research
   grants from the Mitsubishi Tanabe Pharma Corp. (Osaka, Japan) and Kyowa
   Hakko Kirin Co Ltd (Tokyo, Japan) as well as by Management Expenses
   Grants from the Japanese government to Nagoya University.
CR Adachi T, 2004, NAT MED, V10, P1200, DOI 10.1038/nm1119
   Ahmed MS, 2004, J MOL CELL CARDIOL, V36, P393, DOI 10.1016/j.yjmcc.2003.12.004
   Aoyama T, 2005, CIRCULATION, V111, P1652, DOI 10.1161/01.CIR.0000160352.58142.06
   Boustany CM, 2004, AM J PHYSIOL-REG I, V287, pR943, DOI 10.1152/ajpregu.00265.2004
   Carroll JF, 2006, HYPERTENSION, V48, P65, DOI 10.1161/01.HYP.0000224147.01024.77
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   Dhuper S, 2010, OBESITY SILVER SPRIN, V19, P128
   Duffy SJ, 2005, HYPERTENSION, V46, P707, DOI 10.1161/01.HYP.0000184231.84465.62
   El-Menyar AA, 2008, J CARD FAIL, V14, P61, DOI 10.1016/j.cardfail.2007.09.006
   Elmarakby AA, 2005, HYPERTENSION, V45, P283, DOI 10.1161/01.HYP.0000153051.56460.6a
   Fujita T, 2010, HYPERTENSION, V55, P813, DOI 10.1161/HYPERTENSIONAHA.109.149062
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gao X, 2007, CIRCULATION, V115, P245, DOI 10.1161/CIRCULATIONAHA.106.650671
   Grandi AM, 2006, AM J HYPERTENS, V19, P199, DOI 10.1016/j.amjhyper.2005.07.024
   Hattori T, 2011, NUTR DIABETES, V1, DOI 10.1038/nutd.2010.1
   Högye M, 2004, AM J CARDIOL, V94, P249, DOI 10.1016/j.amjcard.2004.03.078
   Jialal I, 2002, FREE RADICAL RES, V36, P1331, DOI 10.1080/1071576021000038531
   Johnson PR, 1997, AM J CLIN NUTR, V66, P890, DOI 10.1093/ajcn/66.4.890
   Kato MF, 2008, J HYPERTENS, V26, P1669, DOI 10.1097/HJH.0b013e328302f0f7
   Kotsis V, 2010, HYPERTENS RES, V33, P386, DOI 10.1038/hr.2010.9
   Kuwahara F, 2004, HYPERTENSION, V43, P739, DOI 10.1161/01.HYP.0000118584.33350.7d
   Lamounier-Zepter V, 2006, HORM METAB RES, V38, P471, DOI 10.1055/s-2006-948137
   Mathieu P, 2009, HYPERTENSION, V53, P577, DOI 10.1161/HYPERTENSIONAHA.108.110320
   Matsui H, 2008, HYPERTENSION, V52, P287, DOI 10.1161/HYPERTENSIONAHA.108.111815
   Matsuzawa Y, 1999, ANN NY ACAD SCI, V892, P146, DOI 10.1111/j.1749-6632.1999.tb07793.x
   Meldrum DR, 1998, ANN THORAC SURG, V65, P439, DOI 10.1016/S0003-4975(97)01297-6
   Mitchell KD, 2006, J RENIN-ANGIO-ALDO S, V7, P74, DOI 10.3317/jraas.2006.013
   Miyachi M, 2009, HYPERTENSION, V53, P701, DOI 10.1161/HYPERTENSIONAHA.108.127290
   Miyata K, 2005, J AM SOC NEPHROL, V16, P2906, DOI 10.1681/ASN.2005040390
   Morimoto A, 1997, LANCET, V350, P1734, DOI 10.1016/S0140-6736(97)05189-1
   Nagase M, 2006, J AM SOC NEPHROL, V17, P3438, DOI 10.1681/ASN.2006080944
   Nagase M, 2009, HYPERTENS RES, V32, P649, DOI 10.1038/hr.2009.86
   Nagata K, 2006, HYPERTENSION, V47, P656, DOI 10.1161/01.HYP.0000203772.78696.67
   Nagata K, 2002, HYPERTENSION, V40, P168, DOI 10.1161/01.HYP.0000026668.50222.1E
   Nagata K, 2008, CURR HYPERTENS REP, V10, P216, DOI 10.1007/s11906-008-0041-y
   Newman WH, 2002, ANESTHESIOLOGY, V96, P947, DOI 10.1097/00000542-200204000-00024
   Plenz G, 1998, THORAC CARDIOV SURG, V46, P213, DOI 10.1055/s-2007-1010227
   Reffelmann T, 2003, BASIC RES CARDIOL, V98, P275, DOI 10.1007/s00395-003-0401-3
   Ren J, 2010, J MOL MED, V88, P993, DOI 10.1007/s00109-010-0663-9
   SAHN DJ, 1978, CIRCULATION, V58, P1072, DOI 10.1161/01.CIR.58.6.1072
   Sakata Y, 2004, CIRCULATION, V109, P2143, DOI 10.1161/01.CIR.0000125741.88712.77
   Sawyer DB, 2002, J MOL CELL CARDIOL, V34, P379, DOI 10.1006/jmcc.2002.1526
   Shibata S, 2008, NAT MED, V14, P1370, DOI 10.1038/nm.1879
   Somura F, 2001, CIRCULATION, V104, P658, DOI 10.1161/hc3101.093869
   Srivastava S, 2009, TOXICOL APPL PHARM, V241, P90, DOI 10.1016/j.taap.2009.08.004
   TEI, 1995, J CARDIOL, V26, P357
   Verma S, 2001, AM J HYPERTENS, V14, P429, DOI 10.1016/S0895-7061(00)01261-9
   Wang CT, 2003, J HYPERTENS, V21, P353, DOI 10.1097/00004872-200302000-00027
   Wong CY, 2005, AM J CARDIOL, V96, P1686, DOI 10.1016/j.amjcard.2005.07.091
   Yamada T, 2009, EUR J PHARMACOL, V615, P163, DOI 10.1016/j.ejphar.2009.05.028
NR 50
TC 58
Z9 65
U1 1
U2 9
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD FEB
PY 2012
VL 35
IS 2
BP 186
EP 193
DI 10.1038/hr.2011.157
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 892WJ
UT WOS:000300316000010
PM 21918527
OA Bronze
DA 2025-06-11
ER

PT J
AU Domingos, F
   Serra, A
AF Domingos, Fernando
   Serra, Adelaide
TI Metabolic syndrome: A multifaceted risk factor for kidney stones
SO SCANDINAVIAN JOURNAL OF UROLOGY
LA English
DT Review
DE hypertension; insulin resistance; metabolic syndrome; nephrolithiasis;
   obesity
ID INSULIN-RESISTANCE; CRYSTAL DEPOSITION; CALCIUM; ASSOCIATION; OXALATE;
   CITRATE; NEPHROLITHIASIS; HYPERTENSION; OVERWEIGHT; MORTALITY
AB Kidney stones and metabolic syndrome (MetS) are common conditions in industrialized countries. There is growing evidence of associations between kidney stone disease and MetS or some of its components. The link between uric acid stones and MetS is well understood, but the link with calcium oxalate (CaOx) stones, the most common kidney stone composition, is more complex, and MetS is frequently overlooked as a risk factor for calcium nephrolithiasis. The physiopathological mechanisms of kidney stone disease in MetS are reviewed in this article. Uric acid stones are a consequence of the excessively acidic urine that results from insulin resistance. The pathophysiology of CaOx stones may include: increased excretion of lithogenesis promoters and decreased excretion of inhibitors; increased risk of Randall's plaque development; and inflammatory damage to renal epithelia by oxidative stress, as a consequence of the insulin-resistant milieu that characterizes MetS. The last mechanism contributes to the adhesion of CaOx crystals to subepithelial calcium deposits working as anchor sites where stones can grow. The predominant MetS features could determine the chemical composition of the stones in each patient. Kidney stones may be a renal manifestation of MetS and features of this syndrome should be looked for in patients with idiopathic nephrolithiasis.
C1 [Domingos, Fernando] Univ Lisbon, Fac Med, Inst Physiol, P-1699 Lisbon, Portugal.
   [Domingos, Fernando; Serra, Adelaide] Hosp Fernando Fonseca, Serv Nephrol, Amadora, Portugal.
   [Serra, Adelaide] Hosp Fernando Fonseca, Outpatient Kidney Stone Clin, Amadora, Portugal.
C3 Universidade de Lisboa; Hospital Professor Doutor Fernando Fonseca, EPE;
   Hospital Professor Doutor Fernando Fonseca, EPE
RP Domingos, F (corresponding author), Hosp Prof Doutor Fernando Fonseca, Serv Nefrol, Estr IC 19, P-2720276 Amadora, Portugal.
EM fdomingos.nefrologia@gmail.com
RI Serra, Maria/G-2187-2012
OI Serra, Maria Adelaide/0000-0003-2332-0579
CR Abate N, 2004, KIDNEY INT, V65, P386, DOI 10.1111/j.1523-1755.2004.00386.x
   Ando R, 2011, INT J UROL, V18, P131, DOI 10.1111/j.1442-2042.2010.02690.x
   Bobulescu IA, 2010, CURR OPIN NEPHROL HY, V19, P393, DOI 10.1097/MNH.0b013e32833aa4ac
   Borghi L, 1999, KIDNEY INT, V55, P2397, DOI 10.1046/j.1523-1755.1999.00483.x
   Byer K, 2005, J UROLOGY, V173, P640, DOI 10.1097/01.ju.0000143190.49888.c7
   Canales BK, 2010, UROLOGY, V76, DOI 10.1016/j.urology.2010.05.005
   Coe FL, 2010, UROL RES, V38, P147, DOI 10.1007/s00240-010-0271-8
   Cupisti A, 2007, BIOMED PHARMACOTHER, V61, P86, DOI 10.1016/j.biopha.2006.09.012
   Domingos F, 2011, NEPHROL DIAL TRANSPL, V26, P864, DOI 10.1093/ndt/gfq501
   Fuster DG, 2007, AM J PHYSIOL-RENAL, V292, pF577, DOI 10.1152/ajprenal.00240.2006
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Hari P, 2012, METAB SYNDR RELAT D, V10, P47, DOI 10.1089/met.2011.0087
   Holoch PA, 2011, J ENDOUROL, V25, P1903, DOI 10.1089/end.2011.0130
   Kadlec AO, 2012, UROLOGY, V80, P805, DOI 10.1016/j.urology.2012.05.011
   Khan SR, 2012, J UROLOGY, V187, P1094, DOI 10.1016/j.juro.2011.10.125
   Kohjimoto Y, 2013, AM J KIDNEY DIS, V61, P923, DOI 10.1053/j.ajkd.2012.12.028
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Li GL, 2007, ENDOCRINOLOGY, V148, P3356, DOI 10.1210/en.2006-1441
   Low RK, 2000, J ENDOUROL, V14, P507, DOI 10.1089/end.2000.14.507
   Sakhaee K, 2009, KIDNEY INT, V75, P585, DOI 10.1038/ki.2008.626
   Schepers MSJ, 2005, KIDNEY INT, V68, P1543, DOI 10.1111/j.1523-1755.2005.00566.x
   Siener R, 2004, OBES RES, V12, P106, DOI 10.1038/oby.2004.14
   Stapleton Phoebe A, 2008, Pathophysiology, V15, P79, DOI 10.1016/j.pathophys.2008.04.007
   Strohmaier WL, 2012, UROL RES, V40, P171, DOI 10.1007/s00240-011-0403-9
   Taguchi K, 2012, J UROLOGY, V188, P1002, DOI 10.1016/j.juro.2012.04.103
   Taylor EN, 2006, AM J KIDNEY DIS, V47, P780, DOI 10.1053/j.ajkd.2006.01.024
   Tiselius HG, 2013, SCAND J UROL, V47, P4, DOI 10.3109/00365599.2012.680489
   Umekawa T, 2004, J AM SOC NEPHROL, V15, P635, DOI 10.1097/01.ASN.0000113321.49771.2D
   VAGUE J, 1956, AM J CLIN NUTR, V4, P20, DOI 10.1093/ajcn/4.1.20
   Wang JJ, 2007, EUR HEART J, V28, P857, DOI 10.1093/eurheartj/ehl524
   Weinberg AE, 2014, EUR UROL, V65, P242, DOI 10.1016/j.eururo.2013.03.026
   West B, 2008, AM J KIDNEY DIS, V51, P741, DOI 10.1053/j.ajkd.2007.12.030
NR 32
TC 31
Z9 33
U1 3
U2 24
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 2168-1805
EI 2168-1813
J9 SCAND J UROL
JI Scand. J. Urol.
PD OCT
PY 2014
VL 48
IS 5
BP 414
EP 419
DI 10.3109/21681805.2014.903513
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA AP6SK
UT WOS:000342207700001
PM 24708398
DA 2025-06-11
ER

PT J
AU Bellon, A
   Nguyen, K
AF Bellon, Alfredo
   Kieuhanh Nguyen
TI Selective serotonin reuptake inhibitors and risk reduction for
   cardiovascular disease in patients with schizophrenia: A controversial
   but promising approach
SO WORLD JOURNAL OF PSYCHIATRY
LA English
DT Review
DE Antidepressants; Metabolic syndrome; Cholesterol; Psychotic disorders;
   Antipsychotics; Body weight
ID WEIGHT-GAIN; METABOLIC SYNDROME; CHOLESTEROL LEVELS; CORONARY EVENTS;
   DRUG-NAIVE; ASSOCIATION; DEPRESSION; MORBIDITY; MORTALITY; DISORDER
AB Patients with schizophrenia (SCZ) are at high risk of cardiovascular disease (CVD) due to an inherited predisposition, a sedentary life style and the use of antipsychotic medications. Several approaches have been taken to minimize this risk but results continue to be unsatisfactory. A potential alternative is prescribing selective serotonin reuptake inhibitors (SSRIs). SSRIs decrease platelet aggregation and reduce the risk of coronary heart disease in patients with depression. We therefore aim to investigate whether there is evidence that supports the use of SSRIs to reduce the risk for CVD in SCZ. A review of the literature revealed five published reports relating to the impact of SSRIs on CV risk in SCZ. Three trials assessed the influence on metabolic parameters of fluvoxamine when combined with clozapine. Two of those studies found improvements with fluvoxamine. Of the other two reports, one indicates SSRIs as a group caused minimal but statistically significant increments in total cholesterol, low-density lipoprotein and triglyceride. The second report suggests that when SSRIs are combined with antipsychotics, the metabolic impact depends on the antipsychotic prescribed. While there are promising results, no conclusions can be made currently on whether SSRIs increase or decrease CV risk in SCZ. Further studies are needed to resolve this matter.
C1 [Bellon, Alfredo] Penn State Hershey Med Ctr, Dept Psychiat & Behav Hlth, 500 Univ Dr, Hershey, PA 17033 USA.
   [Kieuhanh Nguyen] Penn State Hershey Med Ctr, Dept Penn State Coll Med, Hershey, PA 17033 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Pennsylvania State
   University; Penn State Health
RP Bellon, A (corresponding author), Penn State Hershey Med Ctr, Dept Psychiat & Behav Hlth, 500 Univ Dr, Hershey, PA 17033 USA.
EM alfredobellon@yahoo.com
CR Allison DB, 1999, AM J PSYCHIAT, V156, P1686
   Andrade C, 2016, PSYCHIAT CLIN N AM, V39, P413, DOI 10.1016/j.psc.2016.04.010
   Bailey DL, 2003, J CLIN PSYCHOPHARM, V23, P317, DOI 10.1097/00004714-200306000-00016
   BALDESSARINI RJ, 1976, PSYCHIAT ANN, V6, P52
   Beyazyüz M, 2013, PSYCHIAT INVEST, V10, P148, DOI 10.4306/pi.2013.10.2.148
   Chittaranjan A, 2013, INT CLIN PSYCHOPHARM, V28, P145, DOI 10.1097/YIC.0b013e32835d735d
   Cohn T, 2004, CAN J PSYCHIAT, V49, P753, DOI 10.1177/070674370404901106
   De Hert M, 2009, EUR PSYCHIAT, V24, P412, DOI 10.1016/j.eurpsy.2009.01.005
   Dixon L, 2000, SCHIZOPHRENIA BULL, V26, P903, DOI 10.1093/oxfordjournals.schbul.a033504
   Fjukstad KK, 2018, EUR PSYCHIAT, V48, P71, DOI 10.1016/j.eurpsy.2017.04.001
   Fjukstad KK, 2016, J CLIN PSYCHOPHARM, V36, P615, DOI 10.1097/JCP.0000000000000582
   Goff DC, 2005, J CLIN PSYCHIAT, V66, P183, DOI 10.4088/JCP.v66n0205
   Grundy SM, 2004, ARTERIOSCL THROM VAS, V24, pE13, DOI 10.1161/01.ATV.0000111245.75752.C6
   Guo SY, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000015786
   Halperin Demian, 2007, Dialogues Clin Neurosci, V9, P47
   Hasnain M, 2010, CURR DIABETES REP, V10, P209, DOI 10.1007/s11892-010-0112-8
   Herran A, 2006, J CLIN PSYCHOPHARM, V26, P538, DOI 10.1097/01.jcp.0000237941.56107.b7
   Hinze-Selch D, 2000, PSYCHOPHARMACOLOGY, V149, P163, DOI 10.1007/s002139900351
   Hjorthoj C, 2017, LANCET PSYCHIAT, V4, P295, DOI 10.1016/S2215-0366(17)30078-0
   Ifteni P, 2014, SCHIZOPHR RES, V155, P72, DOI 10.1016/j.schres.2014.03.011
   Kim EJ, 2005, J CLIN PSYCHOPHARM, V25, P597, DOI 10.1097/01.jcp.0000186868.67418.f5
   Lahti M, 2012, PSYCHOL MED, V42, P2275, DOI 10.1017/S0033291712000396
   Laursen TM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0067133
   Lekakis J, 2010, INT J CARDIOL, V139, P150, DOI 10.1016/j.ijcard.2008.10.010
   Li N, 1997, BLOOD COAGUL FIBRIN, V8, P517, DOI 10.1097/00001721-199711000-00006
   Lieberman JA, 2005, NEW ENGL J MED, V353, P1209, DOI 10.1056/NEJMoa051688
   Llorente MD., 2006, CLIN DIABETES, V24, P18, DOI DOI 10.2337/DIACLIN.24.1.18
   Lu ML, 2004, J CLIN PSYCHIAT, V65, P766
   Lu ML, 2018, SCHIZOPHR RES, V193, P126, DOI 10.1016/j.schres.2017.06.030
   Lu Mong-Liang, 2000, Journal of Clinical Psychiatry, V61, P594
   MacGillivray S, 2003, BMJ-BRIT MED J, V326, P1014, DOI 10.1136/bmj.326.7397.1014
   McIntyre RS, 2001, J CLIN PSYCHIAT, V62, P23
   Oskouie DS, 2017, NEUROREHAB NEURAL RE, V31, P638, DOI 10.1177/1545968317704902
   Remington Gary, 2016, Curr Treat Options Psychiatry, V3, P133
   Ryan MCM, 2003, AM J PSYCHIAT, V160, P284, DOI 10.1176/appi.ajp.160.2.284
   Scheen AJ, 2007, DIABETES METAB, V33, P169, DOI 10.1016/j.diabet.2007.01.003
   Serebruany VL, 2001, PHARMACOL RES, V43, P453, DOI 10.1006/phrs.2001.0817
   Serebruany VL, 2003, CIRCULATION, V108, P939, DOI 10.1161/01.CIR.0000085163.21752.0A
   Serebruany VL, 2003, EUR J HEART FAIL, V5, P517, DOI 10.1016/S1388-9842(03)00005-9
   Sernyak MJ, 2002, AM J PSYCHIAT, V159, P561, DOI 10.1176/appi.ajp.159.4.561
   Simon V, 2009, J CLIN PSYCHIAT, V70, P1041, DOI 10.4088/JCP.08r04392
   Smith M, 2008, BRIT J PSYCHIAT, V192, P406, DOI 10.1192/bjp.bp.107.037184
   Tamayo JM, 2009, J CLIN PSYCHOPHARM, V29, P358, DOI 10.1097/JCP.0b013e3181ad223f
   Thakore JH, 2002, INT J OBESITY, V26, P137, DOI 10.1038/sj.ijo.0801840
   Von Ruden AE, 2008, J CARDIOVASC PHARM T, V13, P32, DOI 10.1177/1074248407308467
   Yogaratnam J, 2013, East Asian Arch Psychiatry, V23, P21
   Zheng SL, 2019, JAMA-J AM MED ASSOC, V321, P277, DOI 10.1001/jama.2018.20578
NR 47
TC 7
Z9 8
U1 0
U2 2
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2220-3206
J9 WORLD J PSYCHIATR
JI World J. Psychiatr.
PD JUL 19
PY 2021
VL 11
IS 7
BP 316
EP 324
DI 10.5498/wjp.v11.i7.316
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA TR0NY
UT WOS:000678671400005
PM 34327124
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wang, W
   Peng, L
   Gao, XS
   Luo, DY
AF Wang, Wei
   Peng, Liao
   Gao, Xiaoshuai
   Luo, Deyi
TI The Frequency of Metabolic Syndrome in Aged Female Patients (Older Than
   65 Years) With and Without Stress Urinary Incontinence: A Case-Control
   Study
SO FEMALE PELVIC MEDICINE AND RECONSTRUCTIVE SURGERY
LA English
DT Article
DE metabolic syndrome; obesity; body mass index; stress urinary
   incontinence
ID QUALITY-OF-LIFE; TRACT SYMPTOMS; DIABETES-MELLITUS; RISK-FACTORS; WOMEN;
   ASSOCIATION; IMPACT; CHOLESTEROL; POPULATION; COMPONENTS
AB Objective The aim of the study was to assess the incidence of metabolic syndrome (MetS) in aged patients (older than 65 years) with and without stress urinary incontinence (SUI). Methods We evaluated the components of MetS in 460 SUI patients and 460 age-matched women without urinary incontinence from January 2009 to October 2019. Stress urinary incontinence was diagnosed by clinical complaint and the presence of involuntary urine leakage during physical activity. Definition of MetS was on the basis of the National Cholesterol Education Program Adult Treatment Panel III recommendations definition (NCEPATPIII) and the International Diabetes Federation criteria (IDF). Results Totally, 460 SUI patients with the median age of 70 years were eventually included in the study. Subsequently, 460 age-matched controls were selected. The prevalence of MetS was more frequent in SUI patients based on the NCEPATPIII (43.04% vs 19.78%, P < 0.0001) and IDF criteria (45.22% vs 20.22%, P < 0.0001). Moreover, logistic regression analysis revealed that MetS significantly increased the risk of SUI (odds ratio = 3.06, 95% confidence interval = 2.28-4.09) according to the NCEPATPIII definition and (odds ratio = 3.26, 95% confidence interval = 2.43-4.34) on the basis of IDF criteria compared with controls. Patients in the SUI group had a statistically higher body mass index (P < 0.0001), larger waist (P < 0.0001), higher level of fasting blood glucose (P = 0.0001), triglycerides (P = 0.00), and systolic blood pressure (P = 0.0001) than controls. Patients with SUI demonstrated a statistically worse symptom score in all aspects compared with controls (P < 0.0001). Conclusions The prevalence of MetS was higher in older women with SUI than in an age- and sex-matched control group without clinical SUI. Further studies are warranted to determine the pathophysiology mechanism of SUI and MetS.
C1 [Wang, Wei; Peng, Liao; Gao, Xiaoshuai; Luo, Deyi] Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu, Peoples R China.
C3 Sichuan University
RP Luo, DY (corresponding author), Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu, Peoples R China.
EM luodeyi@scu.edu.cn
CR Abrams P, 2015, BJU INT, V115, P143, DOI 10.1111/bju.12852
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Avery K, 2004, NEUROUROL URODYNAM, V23, P322, DOI 10.1002/nau.20041
   Brown JS, 2000, J AM GERIATR SOC, V48, P721, DOI 10.1111/j.1532-5415.2000.tb04744.x
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Dugan E, 2000, J AM GERIATR SOC, V48, P413, DOI 10.1111/j.1532-5415.2000.tb04699.x
   de Oliveira MCE, 2016, DIABET METAB SYND OB, V9, P207, DOI 10.2147/DMSO.S106221
   Gleicher S, 2020, UROLOGY, V145, P100, DOI 10.1016/j.urology.2020.07.028
   Gorbachinsky Ilya, 2010, Rev Urol, V12, pe157
   Haylen BT, 2010, INT UROGYNECOL J, V21, P5, DOI 10.1007/s00192-009-0976-9
   Hill SR, 2008, NEUROUROL URODYNAM, V27, P362, DOI 10.1002/nau.20533
   Hunskaar S, 2008, NEUROUROL URODYNAM, V27, P749, DOI 10.1002/nau.20635
   Kim JH, 2016, SURG OBES RELAT DIS, V12, P1585, DOI 10.1016/j.soard.2016.04.027
   Lim R, 2016, J UROLOGY, V196, P153, DOI 10.1016/j.juro.2016.01.090
   Maserejian NN, 2009, EUR UROL, V55, P1179, DOI 10.1016/j.eururo.2008.07.058
   Ströher RLM, 2020, INT UROGYNECOL J, V31, P173, DOI 10.1007/s00192-019-03880-6
   Otunctemur A, 2014, INT UROL NEPHROL, V46, P1501, DOI 10.1007/s11255-014-0680-7
   Papaefstathiou E, 2019, DIABETES METAB SYND, V13, P454, DOI 10.1016/j.dsx.2018.11.009
   Patrick DL, 1999, UROLOGY, V53, P71, DOI 10.1016/S0090-4295(98)00454-3
   Peng L, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000015572
   Pirro M, 2018, PROG LIPID RES, V71, P54, DOI 10.1016/j.plipres.2018.06.001
   Reynolds W Stuart, 2011, Curr Urol Rep, V12, P370, DOI 10.1007/s11934-011-0206-0
   Russo E, 2021, MATURITAS, V143, P223, DOI 10.1016/j.maturitas.2020.09.005
   Siddiqui NY, 2018, J UROLOGY, V200, P848, DOI 10.1016/j.juro.2018.04.076
   Sun Y, 2017, UROLOGY, V110, P63, DOI 10.1016/j.urology.2017.06.033
   Tai HC, 2010, J CLIN ENDOCR METAB, V95, P1143, DOI 10.1210/jc.2009-1492
   Wang R, 2015, FEMALE PELVIC MED RE, V21, P293, DOI 10.1097/SPV.0000000000000193
   Wang YL, 2015, INT UROGYNECOL J, V26, P911, DOI 10.1007/s00192-015-2626-8
   Zacche MM, 2017, EUR J OBSTET GYN R B, V217, P1, DOI 10.1016/j.ejogrb.2017.08.002
NR 30
TC 5
Z9 5
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2151-8378
EI 2154-4212
J9 FEMALE PELVIC MED RE
JI Female Pelvic Med. Reconstr. Surg.
PD FEB
PY 2022
VL 28
IS 2
BP E11
EP E15
DI 10.1097/SPV.0000000000001122
PG 5
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA YN6PO
UT WOS:000747378800002
PM 34768259
DA 2025-06-11
ER

PT J
AU Bengesser, SA
   Lackner, N
   Birner, A
   Fellendorf, FT
   Platzer, M
   Mitteregger, A
   Unterweger, R
   Reininghaus, B
   Mangge, H
   Wallner-Liebmann, SJ
   Zelzer, S
   Fuchs, D
   McIntyre, RS
   Kapfhammer, HP
   Reininghaus, EZ
AF Bengesser, S. A.
   Lackner, N.
   Birner, A.
   Fellendorf, F. T.
   Platzer, M.
   Mitteregger, A.
   Unterweger, R.
   Reininghaus, B.
   Mangge, H.
   Wallner-Liebmann, S. J.
   Zelzer, S.
   Fuchs, D.
   McIntyre, R. S.
   Kapfhammer, H. P.
   Reininghaus, E. Z.
TI Peripheral markers of oxidative stress and antioxidative defense in
   euthymia of bipolar disorder-Gender and obesity effects
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Bipolar disorder; Oxidative stress; Antioxidants; Clutathione
   S-transferase; Malondiaidehyde; Total antioxidative capacity
ID GLUTATHIONE-S-TRANSFERASE; INDUCED LIPID-PEROXIDATION;
   SUPEROXIDE-DISMUTASE; METABOLIC SYNDROME; NITRIC-OXIDE; PROTEIN
   OXIDATION; INFLAMMATORY CYTOKINES; AUTOIMMUNE RESPONSES; PREFRONTAL
   CORTEX; MAJOR DEPRESSION
AB Introduction: Oxidative and nitrosative stress are implicated in the pathogenesis of uni- and bipolar disorder. Herein we primarily sought to characterize markers of oxidative/nitrosative stress during euthymia in adults with bipolar disorder (BD). Oxidative markers were further evaluated in this BD sample in synopsis with excess overweight or obesity and/or comorbid metabolic syndrome (MetS).
   Methods: Peripheral markers of oxidative stress [i.e thiobarbituric acid reactive substance, (TBARS), malondialdehycle (MDA), and carbonyl proteins] and antioxidant markers [e.g total antioxidative capacity (TAC), superoxide dismutase (SOD), glutathione S-transferase (GST)] were obtained in a cohort of euthymic adults with BD (N=113) and compared to healthy controls (CC) (N=78). Additionally, anthropometric measures included the body mass index (BMI) [kg/m(2)], waist and hip circumference [cm], waist-to-hip-ratio (WHR), waist to height ratio (WtHR) as well as the IDF-defined MetS.
   Results: The major finding was a significantly decreased TAC in BD compared to the CG (p < 0.01; BD: M 1.18, SD 0.47; CG: M 139, SD 0.49). MDA was significantly and TBARS by trend higher in the CG compared to the euthymic bipolar test persons (MDA: p < 0.01, BD: M 0.70, SD 0.18; CG: M 0.81, SD 025; TBARS: p<01, BD: M 0.78, SD 0.28; M 0.76, SD 0.30). The antioxidative enzyme CST was significantly elevated in both patients and controls (BD: M 298.24, SD 133.02; CC:: M 30727 SD 118.18). Subgroup analysis revealed that the CG with concurrent MetS and obesity had significantly elevated TAC when compared to CG without concurrent MetS < 0.05, no MetS: M 1.33, SD 0.50; MetS: M 1.67, SD 032), as well as persons with BD with or without current MetS (no MetS: M 1.18, SD 0.44; MetS: M 1.15, SD 0.49). Significant correlations between GST and anthropometric variables were found in male study participants. Multivariate analysis indicated a significant gender effect concerning TBARS values in all patients and CG (p < 0.01, females: M 0.73, SD 029; males: M 0.83, SD 0.28).
   Conclusion: Euthymic bipolar adults exhibit peripheral evidence of a disturbed biosignature of oxidative stress and antioxidative defense. Male test persons showed significantly higher peripheral markers of oxidative stress than women- female sex may exert protective effects. Furthermore, the biosignature of oxidative stress obtained herein was more pronounced in males with concurrent metabolic disorders. Our results further extend knowledge by introducing the moderating influence of gender and obesity on oxidative stress and BD. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Bengesser, S. A.; Lackner, N.; Birner, A.; Fellendorf, F. T.; Platzer, M.; Mitteregger, A.; Unterweger, R.; Reininghaus, B.; Kapfhammer, H. P.; Reininghaus, E. Z.] Med Graz Univ, Dept Psychiat, A-8036 Graz, Austria.
   [Wallner-Liebmann, S. J.] Inst Pathophysiol & Immunol, Graz, Austria.
   [Mangge, H.; Zelzer, S.] Clin Inst Med & Chem Lab Diagnost, Graz, Austria.
   [Fuchs, D.] Med Univ Innsbruck, Bioctr, Div Biol Chem, A-6020 Innsbruck, Austria.
   [McIntyre, R. S.] Univ Toronto, Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.
   [Reininghaus, B.] Therapiezentrum Justuspk, A-4540 Bad Hall, Austria.
C3 Medical University of Graz; Medical University of Innsbruck; University
   of Toronto; University Health Network Toronto
RP Lackner, N (corresponding author), Med Graz Univ, Dept Psychiat, Auenbruggerpl 31, A-8036 Graz, Austria.
EM Nina.Lackner@medunigraz.at
RI McIntyre, Roger/AAU-1000-2020; Fuchs, Dietmar/AAL-8011-2021
OI Mangge, Harald/0000-0003-4067-247X; Fellendorf,
   Frederike/0000-0001-7215-3848; Reininghaus, Eva/0000-0001-5964-4087
FU Stadt Graz
FX There are no conflicts of interests; we did not receive funding from
   companies (e.g, pharmaceutical industry). We received funding from
   "Stadt Graz",
CR Aksenov MY, 2001, NEUROSCIENCE, V103, P373, DOI 10.1016/S0306-4522(00)00580-7
   Albayrak A, 2013, INT IMMUNOPHARMACOL, V16, P35, DOI 10.1016/j.intimp.2013.03.018
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Andreazza AC, 2008, J AFFECT DISORDERS, V111, P135, DOI 10.1016/j.jad.2008.04.013
   Andreazza AC, 2013, J NEUROCHEM, V127, P552, DOI 10.1111/jnc.12316
   Andreazza AC, 2009, J PSYCHIATR NEUROSCI, V34
   Andreazza AC, 2007, J PSYCHIATR RES, V41, P523, DOI 10.1016/j.jpsychires.2006.07.013
   [Anonymous], NERVENARZT
   [Anonymous], J STEROID BIOCH MOL
   [Anonymous], BIPOLAR DISORD
   [Anonymous], ACHSE I PSYCHISCHE S
   [Anonymous], EUR PSYCHIAT
   [Anonymous], BIPOLAR DISORD
   Bakare A, 2009, NEUROSCI LETT, V455, P70, DOI 10.1016/j.neulet.2009.03.022
   Berk M, 2011, NEUROSCI BIOBEHAV R, V35, P804, DOI 10.1016/j.neubiorev.2010.10.001
   Berk M, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-200
   Bortolasci CC, 2014, J AFFECT DISORDERS, V159, P23, DOI 10.1016/j.jad.2014.02.018
   Dalvi SM, 2013, MALAYS J MED SCI, V20, P21
   Diniz BS, 2013, NEUROPSYCH DIS TREAT, V9, P493, DOI 10.2147/NDT.S33086
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   Fagiolini A, 2008, J CLIN PSYCHIAT, V69, P678, DOI 10.4088/JCP.v69n0423c
   Floor E, 1998, J NEUROCHEM, V70, P268
   Frey BN, 2007, PROG NEURO-PSYCHOPH, V31, P283, DOI 10.1016/j.pnpbp.2006.06.011
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gergerlioglu HS, 2007, PROG NEURO-PSYCHOPH, V31, P697, DOI 10.1016/j.pnpbp.2006.12.020
   Gubert C, 2013, J PSYCHIATR RES, V47, P1396, DOI 10.1016/j.jpsychires.2013.06.018
   Heron P, 2000, METAB BRAIN DIS, V15, P267
   Hoogendoorn B, 2004, HUM MUTAT, V24, P35, DOI 10.1002/humu.20061
   Jornada LK, 2011, J PSYCHIATR RES, V45, P162, DOI 10.1016/j.jpsychires.2010.05.011
   Kapczinski F, 2011, J PSYCHIATR RES, V45, P156, DOI 10.1016/j.jpsychires.2010.05.015
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Khairova R, 2012, MOL MED REP, V5, P680, DOI 10.3892/mmr.2011.732
   Kiray M, 2007, ACTA HISTOCHEM, V109, P480, DOI 10.1016/j.acthis.2007.04.008
   Kuloglu M, 2002, CELL BIOCHEM FUNCT, V20, P171, DOI 10.1002/cbf.940
   Kunz M, 2008, PROG NEURO-PSYCHOPH, V32, P1677, DOI 10.1016/j.pnpbp.2008.07.001
   Leboyer M, 2012, J AFFECT DISORDERS, V141, P1, DOI 10.1016/j.jad.2011.12.049
   Lenaz G, 2000, BBA-BIOENERGETICS, V1459, P397, DOI 10.1016/S0005-2728(00)00177-8
   Machado-Vieira R, 2007, NEUROSCI LETT, V421, P33, DOI 10.1016/j.neulet.2007.05.016
   Maddux BA, 2001, DIABETES, V50, P404, DOI 10.2337/diabetes.50.2.404
   Maes M, 2013, ACTA PSYCHIAT SCAND, V127, P344, DOI 10.1111/j.1600-0447.2012.01908.x
   Maes M, 2013, J AFFECT DISORDERS, V149, P23, DOI 10.1016/j.jad.2012.06.039
   Maes M, 2011, PROG NEURO-PSYCHOPH, V35, P676, DOI 10.1016/j.pnpbp.2010.05.004
   Magalhaes PVS, 2012, INT J NEUROPSYCHOPH, V15, P1043, DOI 10.1017/S1461145711001532
   Mahadik SP, 2001, PROG NEURO-PSYCHOPH, V25, P463, DOI 10.1016/S0278-5846(00)00181-0
   Mangge H, 2004, CLIN CHEM LAB MED, V42, P467, DOI 10.1515/CCLM.2004.081
   Mangge H, 2010, CURR MED CHEM, V17, P4511, DOI 10.2174/092986710794183006
   Matsuoka T, 1997, J CLIN INVEST, V99, P144, DOI 10.1172/JCI119126
   McIntyre RS, 2010, ADV THER, V27, P828, DOI 10.1007/s12325-010-0072-z
   McIntyre RS, 2010, J AFFECT DISORDERS, V126, P366, DOI 10.1016/j.jad.2010.04.012
   Moorthy K, 2005, EXP GERONTOL, V40, P295, DOI 10.1016/j.exger.2005.01.004
   Moylan S, 2013, MOL PSYCHIATR, V18, P595, DOI 10.1038/mp.2012.33
   Nciri R, 2013, INT J NEUROPSYCHOPH, V16, P365, DOI 10.1017/S1461145712000132
   Nishikawa T, 2000, NATURE, V404, P787, DOI 10.1038/35008121
   Nishikawa T, 2000, CURR EYE RES, V21, P581, DOI 10.1076/0271-3683(200007)21:1;1-Z;FT581
   Nishikawa T, 2000, KIDNEY INT, V58, pS26, DOI 10.1046/j.1523-1755.2000.07705.x
   Olusi SO, 2002, INT J OBESITY, V26, P1159, DOI 10.1038/sj.ijo.0802066
   Ozcan ME, 2004, INT CLIN PSYCHOPHARM, V19, P89, DOI 10.1097/01.yic.0000110796.97676.89
   Pajunen P, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-754
   Pedrini M, 2012, J PSYCHIATR RES, V46, P819, DOI 10.1016/j.jpsychires.2012.03.019
   Primeau V, 2011, INT J OBESITY, V35, P971, DOI 10.1038/ijo.2010.216
   Ranjekar PK, 2003, PSYCHIAT RES, V121, P109, DOI 10.1016/S0165-1781(03)00220-8
   Reddy R, 2003, SCHIZOPHR RES, V62, P205, DOI 10.1016/S0920-9964(02)00407-3
   Requintina PJ, 2005, ANN NY ACAD SCI, V1053, P400, DOI 10.1196/annals.1344.035
   Rezaei Z, 2012, PSYCHIAT RES, V198, P166, DOI 10.1016/j.psychres.2011.09.002
   Riadh N, 2011, BIOMETALS, V24, P747, DOI 10.1007/s10534-011-9433-6
   Rodríguez-Santiago B, 2010, MOL PSYCHIATR, V15, P1023, DOI 10.1038/mp.2009.53
   Rudich A, 1998, DIABETES, V47, P1562, DOI 10.2337/diabetes.47.10.1562
   Savas HA, 2006, WORLD J BIOL PSYCHIA, V7, P51, DOI 10.1080/15622970510029993
   Selek S, 2008, J AFFECT DISORDERS, V107, P89, DOI 10.1016/j.jad.2007.08.006
   SMITH CD, 1991, P NATL ACAD SCI USA, V88, P10540, DOI 10.1073/pnas.88.23.10540
   Soczynska JK, 2011, NEUROMOL MED, V13, P93, DOI 10.1007/s12017-010-8140-8
   Spence RD, 2013, J NEUROSCI, V33, P10924, DOI 10.1523/JNEUROSCI.0886-13.2013
   Stefanescu C, 2012, J AFFECT DISORDERS, V143, P34, DOI 10.1016/j.jad.2012.05.022
   Taksali SE, 2008, DIABETES, V57, P367, DOI 10.2337/db07-0932
   Vargas HO, 2014, LIFE SCI, V102, P65, DOI 10.1016/j.lfs.2014.02.033
   Vargas HO, 2013, J AFFECT DISORDERS, V150, P923, DOI 10.1016/j.jad.2013.05.016
   Vincent HK, 2007, DIABETES OBES METAB, V9, P813, DOI 10.1111/j.1463-1326.2007.00692.x
   Yumru M, 2009, PROG NEURO-PSYCHOPH, V33, P1070, DOI 10.1016/j.pnpbp.2009.06.005
   Zelzer S, 2013, FREE RADICAL RES, V47, P651, DOI 10.3109/10715762.2013.812205
NR 79
TC 60
Z9 62
U1 2
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD FEB 1
PY 2015
VL 172
BP 367
EP 374
DI 10.1016/j.jad.2014.10.014
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA AX0LD
UT WOS:000346643000052
PM 25451439
DA 2025-06-11
ER

PT J
AU Gangel, MJ
   Dollar, J
   Brown, A
   Keane, S
   Calkins, SD
   Shanahan, L
   Wideman, L
AF Gangel, Meghan J.
   Dollar, Jessica
   Brown, Ashley
   Keane, Susan
   Calkins, Susan D.
   Shanahan, Lilly
   Wideman, Laurie
TI Childhood social preference and adolescent insulin resistance:
   Accounting for the indirect effects of obesity
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Insulin resistance; Peer preference; Obesity
ID HOMEOSTASIS MODEL ASSESSMENT; BODY-MASS INDEX; TYPE-2 DIABETES-MELLITUS;
   WAIST CIRCUMFERENCE; CARDIOVASCULAR RISK; METABOLIC SYNDROME; CHILDREN;
   MECHANISMS; STRESS; SENSITIVITY
AB Insulin resistance, hyperinsulinemia, and Type II diabetes are increasingly common among young people in the United States. The quality of social relationships is a predictor of cardiometabolic health among adults, but has not been studied as a predictor of earlier insulin resistance. The purpose of this study was to test whether social preference (likeability) during childhood predicts insulin resistance and a measure of central adiposity during adolescence. Obesity also was examined as one mechanism through which this association occurs. Data came from a long-term longitudinal community study. At approximately age 7, 240 children were rated by their classmates on how liked and how disliked they were (difference score indexes social preference). Nine years later, at age 16, the same children visited the university laboratory where height, weight, and several measures of central adiposity (waist circumference, sagittal diameter, and waist-to-height ratio) were assessed by trained interviewers. Adolescents also provided fasted blood samples, from which HOMA-estimated insulin resistance was assessed. A path model yielded adequate to good fit indices, chi(2) (3, N = 240) = 6.689, p =.08, CFI =.97, RMSEA =.07 [95% CI =.00,.14], sRMR =.03. Results indicated that greater social preference at age 7 was significantly associated with lower IR at age 16. These findings suggest that children who are less liked by their classmates are more likely to demonstrate increased risk of IR. Additionally, BMI at age 15 was positively associated with both IR and WC at age 16. A bootstrapping procedure (10,000 draws) indicated that a child's likeability is associated with IR and WC through the association of likeability with later weight status. The quality of social relationships in childhood is important to consider when trying to understand the recent rise in adolescents' cardiometabolic risk and when considering intervention strategies.
C1 [Gangel, Meghan J.; Brown, Ashley; Keane, Susan] Univ North Carolina Greensboro, Dept Psychol, POB 26170, Greensboro, NC 27412 USA.
   [Dollar, Jessica; Calkins, Susan D.] Univ North Carolina Greensboro, Dept Human Dev & Family Studies, Greensboro, NC 27412 USA.
   [Shanahan, Lilly] Univ Zurich, Dept Psychol, Zurich, Switzerland.
   [Shanahan, Lilly] Univ Zurich, Jacobs Ctr Prod Youth Dev, Zurich, Switzerland.
   [Wideman, Laurie] Univ North Carolina Greensboro, Dept Kinesiol, Greensboro, NC 27412 USA.
C3 University of North Carolina; University of North Carolina Greensboro;
   University of North Carolina; University of North Carolina Greensboro;
   University of Zurich; University of Zurich; University of North
   Carolina; University of North Carolina Greensboro
RP Gangel, MJ (corresponding author), Univ North Carolina Greensboro, Dept Psychol, POB 26170, Greensboro, NC 27412 USA.
EM mjrose@uncg.edu
RI Shanahan, Lilly/HNJ-6173-2023; Keane, Susan/JFS-4254-2023
OI Shanahan, Lilly/0000-0002-4534-6924
FU Eunice Kennedy Shriver National Institute Of Child Health & Human
   Development of the National Institutes of Health [R01HD078346]; NIMH
   [55625]
FX Research reported in this publication was supported by the Eunice
   Kennedy Shriver National Institute Of Child Health & Human Development
   of the National Institutes of Health under Award Number R01HD078346.
   Support also came from NIMH 55625, NIMH
CR BAUMEISTER RF, 1995, PSYCHOL BULL, V117, P497, DOI 10.1037/0033-2909.117.3.497
   Begen FM, 2015, PSYCHOL HEALTH, V30, P568, DOI 10.1080/08870446.2014.991734
   Black PH, 2003, BRAIN BEHAV IMMUN, V17, P350, DOI 10.1016/S0889-1591(03)00048-5
   Bowen N., 2012, REPUT SOC PERFORM IM, V43, P435
   BRINDLEY DN, 1989, CLIN SCI, V77, P453, DOI 10.1042/cs0770453
   Bukowski W.M., 2011, Social development: Relationships in infancy, childhood, and adolescence, P153
   CAPRIO S, 1995, AM J PHYSIOL-ENDOC M, V269, pE118, DOI 10.1152/ajpendo.1995.269.1.E118
   Carter CS, 2009, HORMONES, BRAIN AND BEHAVIOR, VOLS 1-5, 2ND EDITION, P137
   Center for Disease Control and Prevention, 2019, Clinical growth charts
   COIE JD, 1982, DEV PSYCHOL, V18, P557, DOI 10.1037/0012-1649.18.4.557
   Dulloo A, 2017, EUR J CLIN NUTR, V71, P353, DOI 10.1038/ejcn.2016.256
   Fitzgerald A, 2012, J ADOLESCENCE, V35, P941, DOI 10.1016/j.adolescence.2012.01.002
   Geer EB, 2014, ENDOCRIN METAB CLIN, V43, P75, DOI 10.1016/j.ecl.2013.10.005
   Goodman E, 2007, PSYCHOSOM MED, V69, P61, DOI 10.1097/01.psy.0000249732.96753.8f
   Gungor N, 2004, J PEDIATR-US, V144, P47, DOI 10.1016/j.jpeds.2003.09.045
   Gungor N, 2005, PEDIATR CLIN N AM, V52, P1579, DOI 10.1016/j.pcl.2005.07.009
   Hanley AJG, 2002, DIABETES CARE, V25, P1177, DOI 10.2337/diacare.25.7.1177
   Hannon TS, 2013, PEDIATR DIABETES, V14, P497, DOI 10.1111/pedi.12035
   Harrist AW, 2016, CHILD DEV, V87, P1564, DOI 10.1111/cdev.12548
   Hollingshead A., 2011, Four factor index of social status, V8, P21
   Huang RC, 2011, DIABETES CARE, V34, P1019, DOI 10.2337/dc10-1809
   Huybrechts I, 2014, NUTR METAB CARDIOVAS, V24, P1082, DOI 10.1016/j.numecd.2014.04.014
   Janssen I, 2002, AM J CLIN NUTR, V75, P683, DOI 10.1093/ajcn/75.4.683
   Johansson I, 2016, J AM COLL CARDIOL, V68, P1404, DOI 10.1016/j.jacc.2016.06.061
   Juonala M, 2013, CURR OPIN LIPIDOL, V24, P57, DOI 10.1097/MOL.0b013e32835a7ed4
   Keskin M, 2005, PEDIATRICS, V115, pE500, DOI 10.1542/peds.2004-1921
   Lacey RE, 2014, PSYCHONEUROENDOCRINO, V50, P85, DOI 10.1016/j.psyneuen.2014.08.007
   Larson RW, 1999, PSYCHOL BULL, V125, P701, DOI 10.1037/0033-2909.125.6.701
   Latner JD, 2003, OBES RES, V11, P452, DOI 10.1038/oby.2003.61
   Lee JM, 2006, DIABETES CARE, V29, P2427, DOI 10.2337/dc06-0709
   Lee S, 2006, J PEDIATR-US, V148, P188, DOI 10.1016/j.jpeds.2005.10.001
   LONG SD, 1994, DIABETES CARE, V17, P372, DOI 10.2337/diacare.17.5.372
   Mamun AA, 2013, INT J OBESITY, V37, P1140, DOI 10.1038/ijo.2012.182
   Marks PEL, 2013, SOC DEV, V22, P609, DOI 10.1111/j.1467-9507.2012.00661.x
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Menke A, 2016, JAMA-J AM MED ASSOC, V316, P344, DOI 10.1001/jama.2016.8544
   Moran A, 1999, DIABETES, V48, P2039, DOI 10.2337/diabetes.48.10.2039
   Muthen LK, 2019, Mplus user's guide
   Peplies J, 2016, INT J BEHAV NUTR PHY, V13, DOI 10.1186/s12966-016-0424-4
   Robinson Sabrina, 2006, J Sch Nurs, V22, P201
   Serlachius A, 2017, INT J BEHAV MED, V24, P161, DOI 10.1007/s12529-016-9597-0
   Shaffer D, 2000, J AM ACAD CHILD PSY, V39, P28, DOI 10.1097/00004583-200001000-00014
   Steinberger J, 2001, J PEDIATR-US, V138, P469, DOI 10.1067/mpd.2001.112658
   Sun SS, 2008, J PEDIATR-US, V152, P191, DOI 10.1016/j.jpeds.2007.07.055
   SVEC F, 1992, DIABETES, V41, P313, DOI 10.2337/diabetes.41.3.313
   Uchino BN, 1996, PSYCHOL BULL, V119, P488, DOI 10.1037/0033-2909.119.3.488
NR 46
TC 8
Z9 10
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAR
PY 2020
VL 113
AR 104557
DI 10.1016/j.psyneuen.2019.104557
PG 7
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA LD3MV
UT WOS:000525937600005
PM 31884323
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Niu, L
   Han, DW
   Xu, RL
   Han, B
   Zhou, X
   Wu, HW
   Li, SH
   Qu, CX
   Liu, M
AF Niu, L.
   Han, D. W.
   Xu, R. L.
   Han, B.
   Zhou, X.
   Wu, H. W.
   Li, S. H.
   Qu, C. X.
   Liu, M.
TI A high-sugar high-fat diet induced metabolic syndrome shows some
   symptoms of Alzheimer's disease in rats
SO JOURNAL OF NUTRITION HEALTH & AGING
LA English
DT Article
DE Metabolic syndrome; sporadic Alzheimer's disease; inflammation; insulin
   resistance; high-sugar high-fat
ID INSULIN-RESISTANCE; ASSOCIATION; MECHANISMS; STRESS; CELLS
AB Cases of sporadic Alzheimer's disease (SAD) are the predominant form of the age-related dementia. New evidence suggests that metabolic syndrome (MS), a metabolic disorder, is an initiating factor of some SAD cases. A high-sugar high-fat diet could cause MS, we aimed to investigate whether it could directly lead to SAD.
   The characteristic molecules of AD (hippocampus A beta and Tau) were tested by using ELISA and western blotting to confirm the happening hallmarks of AD in brain. MS and inflammation related biochemical indicators were measured using immunological method. Proteins associated with the insulin resistance signal pathway (JNK, PI-3K, AKT, GSK-3 beta, GLUT3) were evaluated using western blotting method. The levels of reactive oxygen species (ROS) were measured by immunofluorescence method.
   Expressions of hippocampus A beta, phosphorylation-Tau (p-Tau), inflammatory factors and p-JNK, Gsk-3 beta were higher in the model rats than those in the control rats and expressions of p-PI3K, p-AKT and GLUT3 were reversed.
   The MS model animals, which can induce the characteristics symptoms of AD, and therefore it may be preliminarily considered that the AD pertains to the MS-related diseases.
C1 [Niu, L.; Han, D. W.; Zhou, X.] Shanxi Med Univ, Sch Basic Med Sci, Wuhan, Peoples R China.
   [Niu, L.; Han, D. W.; Xu, R. L.; Zhou, X.] Shanxi Med Univ, Inst Liver Dis, New South Rd 56, Taiyuan 030001, Shanxi, Peoples R China.
   [Han, B.] Shanxi Med Univ, Hosp 1, Dept Mental Hlth, Wuhan 030001, Peoples R China.
   [Wu, H. W.] Shanxi Med Univ, Res Ctr, Fenyang Coll, Fenyang 032299, Peoples R China.
   [Li, S. H.] Shanxi Prov Tumor Hosp, Dept Pathol, Taiyuan 030013, Peoples R China.
   [Qu, C. X.] Peoples Hosp Shanxi Prov, Dept Pathol, Taiyuan 030012, Peoples R China.
   [Liu, M.] Shanxi Med Univ, Sch Basic Med Sci, Taiyuan 030001, Peoples R China.
C3 Shanxi Medical University; Shanxi Medical University; Shanxi Medical
   University; Shanxi Medical University; Shanxi People's Hospital; Shanxi
   Medical University
RP Han, DW (corresponding author), Shanxi Med Univ, Inst Liver Dis, New South Rd 56, Taiyuan 030001, Shanxi, Peoples R China.
EM nltys2004@163.com
FU natural science foundation of China [81302220]; Scientific and
   technological project of Shanxi Province [2014021040-3, 2014021037-1]
FX This study was supported by the the natural science foundation of China.
   (Grant No. 81302220) and Scientific and technological project of Shanxi
   Province. (Grant No. 2014021040-3, No. 2014021037-1). The Corresponding
   Authors have the right to grant on behalf of all authors and does grant
   on behalf of all authors. The manuscript has not been published
   elsewhere and has not been submitted simultaneously for publication
   elsewhere. All study participants provided informed consent, and the
   study design was approved by the appropriate ethics review boards. All
   the authors have approved the manuscript and agree with submission to
   your esteemed journal. There are no conflicts of interest to declare. An
   exclusive license (or non exclusive for government employees) on a
   worldwide basis to the Elsevier to permit this article (if accepted) to
   be published in The journal of nutrition, health & aging and sublicenses
   such use and exploit all subsidiary rights, as set out in our license.
CR Barnard ND, 2014, NEUROBIOL AGING, V35, pS74, DOI 10.1016/j.neurobiolaging.2014.03.033
   Cai H.-Y., 2014, Neuroscience
   Cheng XJ, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0130432
   Chi LY, 2008, MED HYPOTHESES, V71, P283, DOI 10.1016/j.mehy.2008.02.012
   Choi BR, 2014, EXP MOL MED, V46, DOI 10.1038/emm.2013.147
   Craft S, 2007, CURR ALZHEIMER RES, V4, P147, DOI 10.2174/156720507780362137
   DeFronzo RA, 2004, INT J CLIN PRACT, V58, P9, DOI 10.1111/j.1368-504X.2004.00389.x
   Elrod JW, 2013, CIRC J, V77, P1111, DOI 10.1253/circj.CJ-13-0321
   Han B, 2012, CHECH PSYCHIAFIE S1, P187
   Harte AL, 2010, J INFLAMM-LOND, V7, DOI 10.1186/1476-9255-7-15
   Christian H, 2007, EUR J PHARMACOL, V561, P85, DOI 10.1016/j.ejphar.2007.01.040
   Knight EM, 2014, NEUROBIOL AGING, V35, P1821, DOI 10.1016/j.neurobiolaging.2014.02.010
   Ma R, 2009, NEUROPHARMACOLOGY, V56, P1027, DOI 10.1016/j.neuropharm.2009.02.006
   Mehta NN, 2010, DIABETES, V59, P172, DOI 10.2337/db09-0367
   Meigs JB, 2007, DIABETES CARE, V30, P2529, DOI 10.2337/dc07-0817
   Monteiro R, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/289645
   Morris MC, 2014, NEUROBIOL AGING, V35, pS59, DOI 10.1016/j.neurobiolaging.2014.03.038
   Nanes MS, 2003, GENE, V321, P1, DOI 10.1016/S0378-1119(03)00841-2
   Rasgon N, 2004, J GERONTOL A-BIOL, V59, P178
   Sabio G, 2010, MOL CELL BIOL, V30, P106, DOI 10.1128/MCB.01162-09
   Schulingkamp RJ, 2000, NEUROSCI BIOBEHAV R, V24, P855, DOI 10.1016/S0149-7634(00)00040-3
   Serneels L., 2009, SCIENCE, V324, P639, DOI DOI 10.1126/SCIENCE.LL71176
   Sims-Robinson C, 2010, NAT REV NEUROL, V6, P551, DOI 10.1038/nrneurol.2010.130
   Solinas G, 2007, CELL METAB, V6, P386, DOI 10.1016/j.cmet.2007.09.011
   Takeda S, 2013, NEUROBIOL AGING, V34, P2064, DOI 10.1016/j.neurobiolaging.2013.02.010
   Talbot K, 2012, J CLIN INVEST, V122, P1316, DOI 10.1172/JCI59903
   Tamagno E, 2005, J NEUROCHEM, V92, P628, DOI 10.1111/j.1471-4159.2004.02895.x
   Tan XB, 2015, J GINSENG RES, V39, P116, DOI 10.1016/j.jgr.2014.09.002
   Tirosh A, 1999, J BIOL CHEM, V274, P10595, DOI 10.1074/jbc.274.15.10595
   Vanhanen M, 2006, NEUROLOGY, V67, P843, DOI 10.1212/01.wnl.0000234037.91185.99
   Winnay JN, 2010, NAT MED, V16, P438, DOI 10.1038/nm.2121
   Wu HW, 2014, NUTR NEUROSCI
   Zetterberg H, 2010, EXP GERONTOL, V45, P23, DOI 10.1016/j.exger.2009.08.002
   Zhang Y, 2013, J MATER CHEM B, V1, P132, DOI 10.1039/c2tb00071g
   Zhou X, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0115148
NR 35
TC 36
Z9 38
U1 3
U2 24
PU SPRINGER FRANCE
PI PARIS
PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE
SN 1279-7707
EI 1760-4788
J9 J NUTR HEALTH AGING
JI J. Nutr. Health Aging
PD MAY
PY 2016
VL 20
IS 5
BP 509
EP 513
DI 10.1007/s12603-015-0601-1
PG 5
WC Geriatrics & Gerontology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Nutrition & Dietetics
GA DM4BA
UT WOS:000376289300007
PM 27102788
OA hybrid
DA 2025-06-11
ER

PT J
AU Baranowska, B
   Kochanowski, J
   Grudniak, M
   Wolinska-Witort, E
   Kalisz, M
   Bik, W
AF Baranowska, Boguslawa
   Kochanowski, Jan
   Grudniak, Mariusz
   Wolinska-Witort, Ewa
   Kalisz, Malgorzata
   Bik, Wojciech
TI Plasma NPY concentrations in women with acute ischemic stroke
SO NEUROENDOCRINOLOGY LETTERS
LA English
DT Article
DE NPY; acute ischemic stroke
ID Y-RECEPTOR SUBTYPES; NEUROPEPTIDE-Y; METABOLIC SYNDROME; BRAIN PEPTIDE;
   OBESE WOMEN; STRESS; LEPTIN; INSULIN; GALANIN; HYPERTENSION
AB OBJECTIVE: It has been reported that plasma NPY levels were increased in obesity, type 2 diabetes mellitus and hypertension. The symptoms of metabolic syndrome frequently appear in patients with acute ischemic stroke. The association between plasma NPY levels and metabolic markers in women with acute ischemic stroke was investigated in the current study.
   METHODS: Plasma NPY concentrations were determined using radioimmunoassay in 58 women aged 60-85 (mean age: 76.5 +/- 0.8) with acute ischemic stroke and in 24 women aged 63-67 (mean age: 65.6 +/- 0.6) of the control group. Stroke was defined according to the NIHSS (National Institute of Health Stroke Scale) and was confirmed using CT or MR scan.
   RESULTS: The prevalence of type 2 diabetes, hypertension and insulin resistance was higher in the group of patients with stroke. Plasma NPY levels measured during the 1st day and 10 days after the acute phase of stroke were significantly lower (p<0.001) compared to the control group.
   CONCLUSION: In women with acute ischemic stroke plasma NPY concentrations were decreased in spite of higher frequency of the occurrence of the symptoms of metabolic syndrome.
C1 [Baranowska, Boguslawa] Med Ctr Postgrad Educ, Dept Clin Physiol, PL-01813 Warsaw, Poland.
   [Kochanowski, Jan; Grudniak, Mariusz] Med Univ Warsaw, Dept Neurol, Warsaw, Poland.
   [Wolinska-Witort, Ewa; Kalisz, Malgorzata; Bik, Wojciech] Med Ctr Postgrad Educ, Dept Neuroendocrinol, PL-01813 Warsaw, Poland.
C3 Centre of Postgraduate Medical Education - Poland; Medical University of
   Warsaw; Centre of Postgraduate Medical Education - Poland
RP Baranowska, B (corresponding author), Med Ctr Postgrad Educ, Dept Neuroendocrinol, Dept Clin Physiol, Marymoncka 99-103, PL-01813 Warsaw, Poland.
EM zncmkp@op.pl
RI Bik, Wojciech/S-3755-2019
OI Bik, Wojciech/0000-0001-5925-8573; Kochanowski, Jan/0000-0003-0263-2274;
   Kalisz, Malgorzata/0000-0003-3060-1141
FU scientific grant NCN [5484/B/P01/2011/40]
FX This work was supported by scientific grant NCN No. 5484/B/P01/2011/40.
CR Abe K, 2010, EXP BIOL MED, V235, P1179, DOI 10.1258/ebm.2010.009136
   ADRIAN TE, 1983, NATURE, V306, P584, DOI 10.1038/306584a0
   Baltazi M, 2011, AM J CARDIOVASC DIS, V1, P48
   Baranowska B, 1997, METABOLISM, V46, P1384, DOI 10.1016/S0026-0495(97)90136-0
   Baranowska B, 2003, NEUROENDOCRINOL LETT, V24, P431
   Baranowska B, 2000, MENOPAUSE, V7, P149, DOI 10.1097/00042192-200007030-00004
   Baranowska B, 2007, NEUROBIOL AGING, V28, P774, DOI 10.1016/j.neurobiolaging.2006.03.014
   Berglund MM, 2003, EXP BIOL MED, V228, P217, DOI 10.1177/153537020322800301
   Bi S, 2012, NEUROPEPTIDES, V46, P309, DOI 10.1016/j.npep.2012.09.002
   Blomqvist AG, 1997, TRENDS NEUROSCI, V20, P294, DOI 10.1016/S0166-2236(96)01057-0
   Brass L M, 1996, J Stroke Cerebrovasc Dis, V6, P72, DOI 10.1016/S1052-3057(96)80006-1
   Chen SH, 2002, FREE RADICAL BIO MED, V32, P776, DOI 10.1016/S0891-5849(02)00774-8
   Chronwall BA, 2004, PEPTIDES, V25, P359, DOI 10.1016/j.peptides.2004.02.013
   Croce N, 2012, ACS CHEM NEUROSCI, V3, P312, DOI 10.1021/cn200127e
   Croce N, 2011, NEURODEGENER DIS, V8, P300, DOI 10.1159/000323468
   Decressac M, 2012, EXP NEUROL, V238, P265, DOI 10.1016/j.expneurol.2012.09.004
   Dumont Y, 1998, J COMP NEUROL, V402, P372
   EKBLAD E, 1984, REGUL PEPTIDES, V8, P225, DOI 10.1016/0167-0115(84)90064-8
   Gericke MT, 2012, MOL CELL ENDOCRINOL, V348, P27, DOI 10.1016/j.mce.2011.07.028
   Grudniak M, 2010, PROGR MED, V4, P329
   Hansel DE, 2001, NATURE, V410, P940, DOI 10.1038/35073601
   Herzog H, 1997, GENOMICS, V41, P315, DOI 10.1006/geno.1997.4684
   Howell OW, 2007, NEUROBIOL DIS, V26, P174, DOI 10.1016/j.nbd.2006.12.014
   Ilhan A, 2010, NEUROPEPTIDES, V44, P485, DOI 10.1016/j.npep.2010.08.001
   Jaakkola U, 2010, MICROVASC RES, V80, P433, DOI 10.1016/j.mvr.2010.07.010
   Kalra SP, 2008, NUTRITION, V24, P820, DOI 10.1016/j.nut.2008.06.023
   Kim NS, 2009, CLIN BIOCHEM, V42, P1699, DOI 10.1016/j.clinbiochem.2009.07.012
   Ko MM, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/109796
   Kuo LE, 2008, ANN NY ACAD SCI, V1148, P232, DOI 10.1196/annals.1410.035
   LETTGEN B, 1994, J HUM HYPERTENS, V8, P345
   Michalkiewicz M, 2005, HYPERTENSION, V45, P780, DOI 10.1161/01.HYP.0000153953.69799.f2
   Milewicz A, 2000, INT J OBESITY, V24, pS152, DOI 10.1038/sj.ijo.0801310
   Morris MJ, 1997, HYPERTENSION, V29, P137, DOI 10.1161/01.HYP.29.1.137
   Pons Jennifer, 2004, Curr Opin Investig Drugs, V5, P957
   Rasmusson AM, 2010, EXP BIOL MED, V235, P1150, DOI 10.1258/ebm.2010.009334
   Ruohonen ST, 2009, NEUROENDOCRINOLOGY, V89, P351, DOI 10.1159/000188602
   TATEMOTO K, 1982, NATURE, V296, P659, DOI 10.1038/296659a0
   TATEMOTO K, 1982, P NATL ACAD SCI-BIOL, V79, P5485, DOI 10.1073/pnas.79.18.5485
   van den Hoek AM, 2008, DIABETES, V57, P2304, DOI 10.2337/db07-1658
   Wocial B., 1995, Blood Pressure, V4, P143, DOI 10.3109/08037059509077586
   Yu JT, 2010, CLIN CHIM ACTA, V411, P242, DOI 10.1016/j.cca.2009.11.011
   ZARJEVSKI N, 1993, ENDOCRINOLOGY, V133, P1753, DOI 10.1210/en.133.4.1753
   Zhang L, 2011, PHARMACOL THERAPEUT, V131, P91, DOI 10.1016/j.pharmthera.2011.03.011
   ZukowskaGrojec Z, 1995, ANN NY ACAD SCI, V771, P219, DOI 10.1111/j.1749-6632.1995.tb44683.x
NR 44
TC 8
Z9 11
U1 0
U2 4
PU MAGHIRA & MAAS PUBLICATIONS
PI STOCKHOLM
PA PO BOX 26132, S-100 41 STOCKHOLM, SWEDEN
SN 0172-780X
J9 NEUROENDOCRINOL LETT
JI Neuroendocrinol. Lett.
PY 2013
VL 34
IS 2
BP 124
EP 128
PG 5
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA AA2AZ
UT WOS:000330898800007
PM 23645309
DA 2025-06-11
ER

PT J
AU Xie, YD
   Yang, YP
   Li, S
   Xu, YH
   Lu, WF
   Chen, ZZ
   Yang, GD
   Li, YP
   Cao, YX
   Bian, XL
AF Xie, Yundong
   Yang, Yaping
   Li, Sen
   Xu, Yanhong
   Lu, Wenfang
   Chen, Zizhang
   Yang, Guangde
   Li, Yiping
   Cao, Yongxiao
   Bian, Xiaoli
TI Phenylsulfonylfuroxan NO-donor phenols: Synthesis and multifunctional
   activities evaluation
SO BIOORGANIC & MEDICINAL CHEMISTRY
LA English
DT Article
DE Phenylsulfonyfuroxan; Antioxidant; Yeast alpha-glucosidase;
   Anti-glycosylation; Anti-platelet aggregation; Vasodilatation; Metabolic
   syndrome
ID NITRIC-OXIDE; METABOLIC SYNDROME; OXIDATIVE STRESS; ANTIGLYCATION
   PROPERTIES; BIOLOGICAL EVALUATION; ANTIOXIDANT STATUS; GREEN TEA;
   INFLAMMATION; DERIVATIVES; ATHEROSCLEROSIS
AB Phenylsulfonyfuroxan nitric oxide (NO)-donor phenols were designed, synthesized and evaluated. The compounds were designed through a symbiotic approach using selected phenols and phenylsulfonylfuroxan NO-donor. The antioxidant activities of the hybrid compounds T-2-T-6 showed to be good in vivo. Compounds T-4 and T-6 revealed excellent yeast alpha-glucosidase inhibitory activity and anti-glycosylation activity. All of the compounds exhibited strong NO releasing activity and significant anti-platelet aggregation activity. The inhibition of platelet aggregation was more than 50% at low concentration (1.5 mu M) and 95% at higher concentration (15 mu M and 150 mu M). The vasodilatation experiment demonstrated that the six compounds under test exhibited definite vasodilation activity (pIC(50) ranged from 5.698 to 6.383), especially compound T6 (pIC(50) was 6.383) which was similar to sodium nitroprusside (pIC(50) was 6.786). Both anticoagulant and vasodilatation effects were correlated with their NO releasing activities. These hybrid phenylsulfonyfuroxan-based NO-donor phenols offer a multifunctional prodrug design concept for the development of therapeutic or preventive agents for metabolic syndrome. (C) 2017 Published by Elsevier Ltd.
C1 [Xie, Yundong; Yang, Yaping; Xu, Yanhong; Lu, Wenfang; Chen, Zizhang; Yang, Guangde; Li, Yiping; Bian, Xiaoli] Xi An Jiao Tong Univ, Coll Pharm, 76 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China.
   [Li, Sen; Cao, Yongxiao] Xi An Jiao Tong Univ, Sch Basic Med Sci, 76 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China.
C3 Xi'an Jiaotong University; Xi'an Jiaotong University
RP Bian, XL (corresponding author), Xi An Jiao Tong Univ, Coll Pharm, 76 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China.
EM xieshijiaoda405@stu.xjtu.edu.cn
RI Xie, Yundong/MVX-4149-2025; LI, SEN/LMM-9462-2024
FU National Natural Science Foundation of China [21172177]
FX This work was supported by the National Natural Science Foundation of
   China (Grant No. 21172177).
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Bian XL, 2013, BIOORGAN MED CHEM, V21, P5442, DOI 10.1016/j.bmc.2013.06.002
   Bonomini F, 2015, AGING DIS, V6, P109, DOI 10.14336/AD.2014.0305
   Boschi D, 2006, J MED CHEM, V49, P2886, DOI 10.1021/jm0510530
   Choi CI, 2016, RUSS J BIOORG CHEM+, V42, P310, DOI 10.1134/S1068162016030079
   Fernández-Garcia JC, 2013, CURR VASC PHARMACOL, V11, P906, DOI 10.2174/15701611113116660175
   FURCHGOTT RF, 1989, FASEB J, V3, P2007, DOI 10.1096/fasebj.3.9.2545495
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Guzik TJ, 2003, J PHYSIOL PHARMACOL, V54, P469
   HALLIWELL B, 1987, ANAL BIOCHEM, V165, P215, DOI 10.1016/0003-2697(87)90222-3
   IGNARRO LJ, 1989, FASEB J, V3, P31, DOI 10.1096/fasebj.3.1.2642868
   Jun L, 2012, FOOD SCI BIOTECHNOL, V31, P159
   Kang BR, 2015, BIOORG MED CHEM LETT, V25, P5808, DOI 10.1016/j.bmcl.2015.10.018
   KEANEY JF, 1995, PROG CARDIOVASC DIS, V38, P129, DOI 10.1016/S0033-0620(05)80003-9
   KUBES P, 1992, AM J PHYSIOL, V262, pH611, DOI 10.1152/ajpheart.1992.262.2.H611
   Lee J.M., 2001, SYNTHESIS-STUTTGART, V15, P2247
   Lunceford N, 2005, FITOTERAPIA, V76, P419, DOI 10.1016/j.fitote.2005.03.021
   MCPHERSON JD, 1988, BIOCHEMISTRY-US, V27, P1901, DOI 10.1021/bi00406a016
   Nakagawa T, 2002, J AGR FOOD CHEM, V50, P2418, DOI 10.1021/jf011339n
   Nayak D U, 2001, Heart Dis, V3, P28
   Otani H, 2011, ANTIOXID REDOX SIGN, V15, P1911, DOI 10.1089/ars.2010.3739
   Paoletti R, 2006, VASC HEALTH RISK MAN, V2, P145, DOI 10.2147/vhrm.2006.2.2.145
   Pekkarinen SS, 1999, J AGR FOOD CHEM, V47, P3036, DOI 10.1021/jf9813236
   Russo C, 1998, J HYPERTENS, V16, P1267, DOI 10.1097/00004872-199816090-00007
   Shaw Catherine A., 2006, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, V5, P27, DOI 10.2174/187152306775537300
   Stevens KK, 2016, NEPHROL DIAL TRANSPL, P1
   TSE WY, 1994, J HUM HYPERTENS, V8, P843
   Tu SL, 2014, CHEM PHARM BULL, V62, P1185, DOI 10.1248/cpb.c14-00449
   Wang XL, 2013, BIOORG MED CHEM LETT, V23, P1985, DOI 10.1016/j.bmcl.2013.02.035
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Xi MM, 2008, PHYTOTHER RES, V22, P228, DOI 10.1002/ptr.2297
   Yagi S, 2013, S AFR J BOT, V84, P124, DOI 10.1016/j.sajb.2012.10.006
   Yuan H, 2013, EUR J MED CHEM, V62, P148, DOI 10.1016/j.ejmech.2012.09.047
   Zhang SQ, 2009, CHINESE J ORG CHEM, V29, P966
NR 34
TC 10
Z9 10
U1 2
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0968-0896
EI 1464-3391
J9 BIOORGAN MED CHEM
JI Bioorg. Med. Chem.
PD AUG 15
PY 2017
VL 25
IS 16
BP 4407
EP 4413
DI 10.1016/j.bmc.2017.06.023
PG 7
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry,
   Organic
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
GA FB3DO
UT WOS:000406023000018
PM 28651914
DA 2025-06-11
ER

PT J
AU Saban-Ruiz, J
   Ly-Pen, D
AF Saban-Ruiz, J.
   Ly-Pen, D.
TI COVID-19: A Personalized Cardiometabolic Approach for Reducing
   Complications and Costs. The Role of Aging Beyond Topics
SO JOURNAL OF NUTRITION HEALTH & AGING
LA English
DT Article
DE Metabolic Syndrome; cardiometabolic syndrome; cardiometabolic risk;
   cardiometabolic health; atherothrombotic disease; endothelial
   dysfunction
ID CONGESTIVE-HEART-FAILURE; EXPERIMENTAL-MODEL; SARS CORONAVIRUS;
   MANAGEMENT; RECEPTOR; PROTEIN; ACE2; INFECTIONS; SYSTEMS; HEALTH
AB COVID 19 is much more than an infectious disease by SARS-CoV-2 followed by a disproportionate immune response. An older age, diabetes and history of cardiovascular disease, especially hypertension, but also chronic heart failure and coronary artery disease among others, are between the most important risk factors. In addition, during the hospitalization both hyperglycaemia and heart failure are frequent. Less frequent are acute coronary syndrome, arrhythmias and stroke. Accordingly, not all prolonged stays or even deaths are due directly to SARS-CoV-2. To our knowledge, this is the first review, focusing both on cardiovascular and metabolic aspects of this dreadful disease, in an integrated and personalized way, following the guidelines of the Cardiometabolic Health/Medicine. Therefore, current personalized aspects such as ACEIs and ARBs, the place of statins and the most appropriate management of heart failure in diabetics are analysed. Aging, better than old age, as a dynamic process, is also considered in this review for the first time in the literature, and not only as a risk factor attributed to cardiovascular and non-cardiovascular comorbidities. Immunosenescence is also approached to build healthier elders, so they can resist present and future infectious diseases, and not only in epidemics or pandemics. In addition, to do this we must start knowing the molecular mechanisms that underlying Aging process in general, and immunosenescence in particular. Surprisingly, the endoplasmic reticulum stress and autophagy are implicated in both process. Finally, with a training in all the aspects covered in this review, not only the hospital stay, complications and costs of this frightening disease in high-risk population should be reduced. Likely, this paper will open a gate to the future for open-minded physicians.
C1 [Saban-Ruiz, J.] D Med Clin, Antiaging & Cardiometab Hlth Unit, Madrid, Spain.
   [Saban-Ruiz, J.] Helicopteros Sanitarios Hosp, Marbella, Spain.
   [Saban-Ruiz, J.] Int Med Acad IMA, Costa Del Sol, Spain.
   [Ly-Pen, D.] Abbey House Med Ctr, Navan, Co Meath, Ireland.
RP Saban-Ruiz, J (corresponding author), D Med Clin, Madrid, Spain.
EM psaban@gmail.com
CR Aiello A, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.02247
   Alanazi KH, 2020, EMERG INFECT DIS, V26, P166, DOI 10.3201/eid2601.190952
   ALGHATRIF M, JAMA CARDIOL
   Altschul R., 1954, ENDOTHELIUM ITS DEV
   [Anonymous], JAMA CARDIOL
   Asselta Rosanna, 2020, Aging (Albany NY), V12, P10087, DOI 10.18632/aging.103415
   Back SH, 2012, EXP DIABETES RES, DOI 10.1155/2012/618396
   BAUE AE, 1975, ARCH SURG-CHICAGO, V110, P779
   BAVISHI C, JAMA CARDIOL
   Bell DM, 2004, EMERG INFECT DIS, V10, P1900, DOI 10.3201/eid1011.040729
   Bettigole SE, 2015, ANNU REV IMMUNOL, V33, P107, DOI 10.1146/annurev-immunol-032414-112116
   Bloomgarden ZT, 2020, J DIABETES, V12, P347, DOI 10.1111/1753-0407.13027
   BONOW RO, JAMA CARDIOL
   Caly Leon, 2020, Antiviral Res, V178, P104787, DOI 10.1016/j.antiviral.2020.104787
   Chadwick SR, 2019, FRONT CELL DEV BIOL, V7, DOI 10.3389/fcell.2019.00084
   Chan JFW, 2013, TRENDS MICROBIOL, V21, P544, DOI 10.1016/j.tim.2013.05.005
   Chen C, 2020, HERZ, V45, P230, DOI 10.1007/s00059-020-04909-z
   Corsino L., 2017, Management of diabetes and hyperglycemia in hospitalized patients
   Cruz-Lopez F, 2017, RES VET SCI, V115, P88, DOI 10.1016/j.rvsc.2017.01.022
   Del Piero F, 2000, VET PATHOL, V37, P287, DOI 10.1354/vp.37-4-287
   Dinarello Charles A, 2015, Temperature (Austin), V2, P8, DOI 10.1080/23328940.2015.1017086
   Ding WX, 2012, BIOL CHEM, V393, P547, DOI 10.1515/hsz-2012-0119
   DRIGGIN E, 2020, J AM COLL CARDIOLOGY
   EDWARDS S, 1992, J INFECT DIS, V165, P134, DOI 10.1093/infdis/165.1.134
   Farmakis D, 2020, EUR J HEART FAIL, V22, P1755, DOI 10.1002/ejhf.1929
   Gosmanov AR, 2013, CURR DIABETES REP, V13, P155, DOI 10.1007/s11892-012-0335-y
   Gradman AH, 2006, PROG CARDIOVASC DIS, V48, P326, DOI 10.1016/j.pcad.2006.02.001
   Guan WJ, 2020, EUR RESP J
   Guarner J, 2020, AM J CLIN PATHOL, V153, P420, DOI 10.1093/ajcp/aqaa029
   Guo T, 2020, JAMA CARDIOL, V5, P811, DOI 10.1001/jamacardio.2020.1017
   Guo YR, 2020, MILITARY MED RES, V7, DOI 10.1186/s40779-020-00240-0
   Guy JL, 2003, BIOCHEMISTRY-US, V42, P13185, DOI 10.1021/bi035268s
   Hamming I, 2004, J PATHOL, V203, P631, DOI 10.1002/path.1570
   HAN Y, 2020, CSC EXPERT CONSENSUS
   HANEFELD M, 1981, DEUT GESUNDHEITSWES, V36, P545
   Ho JE, 2012, EUR HEART J, V33, P1734, DOI 10.1093/eurheartj/ehs070
   Hodson R, 2016, NATURE, V537, pS49, DOI 10.1038/537S49a
   Hofmann H, 2005, P NATL ACAD SCI USA, V102, P7988, DOI 10.1073/pnas.0409465102
   Huang CL, 2020, LANCET, V395, P497, DOI 10.1016/S0140-6736(20)30183-5
   Imai Y, 2008, EXP PHYSIOL, V93, P543, DOI 10.1113/expphysiol.2007.040048
   Jager A, 1999, ARTERIOSCL THROM VAS, V19, P3071, DOI 10.1161/01.ATV.19.12.3071
   Kamide K, 2004, J HYPERTENS, V22, P121, DOI 10.1097/00004872-200401000-00021
   Landry GJ, 2018, J VASC SURG, V68, P1499, DOI 10.1016/j.jvs.2018.01.050
   Lavi E, 1999, J NEUROPATH EXP NEUR, V58, P1197, DOI 10.1097/00005072-199912000-00001
   Le Couteur DG, 2010, J GERONTOL A-BIOL, V65, P1025, DOI 10.1093/gerona/glq135
   Li J., 2007, Zhonghua yi xue za zhi, V87, P833, DOI DOI 10.3760/J:ISSN:0376-2491.2007.12.013
   Li Q, 2020, NEW ENGL J MED, V382, P1199, DOI 10.1056/NEJMoa2001316
   Liu SF, 2019, JAMA CARDIOL, V4, P949, DOI 10.1001/jamacardio.2019.2214
   Lu RJ, 2020, LANCET, V395, P565, DOI 10.1016/S0140-6736(20)30251-8
   Lurie N, 2020, NEW ENGL J MED, V382, P1969, DOI 10.1056/NEJMp2005630
   Maamoun H, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20071658
   Maier HJ, 2012, P NATL ACAD SCI USA, V109, P11794, DOI 10.1073/pnas.1116584109
   Meo SA, 2020, EUR REV MED PHARMACO, V24, P2012, DOI 10.26355/eurrev_202002_20379
   Michelen M, 2020, PATIENTS COVID 19 WH
   Minahan R E, 1997, New Horiz, V5, P406
   MINANO FJ, 1991, BRAIN RES BULL, V27, P701, DOI 10.1016/0361-9230(91)90049-P
   Miranda JJ, 2019, NAT MED, V25, P1667, DOI 10.1038/s41591-019-0644-7
   MOUNIR S, 1992, J GEN VIROL, V73, P2731, DOI 10.1099/0022-1317-73-10-2731
   multicenter collaboration group of Department of S Technology of Guangdong P Health Commission of Guangdong Province for chloroquine in the treatment of novel coronavirus p, 2020, ZHONGHUA JIE HE HE H, V43, pE019, DOI DOI 10.2337/DC20-S012
   Neuman BW, 2011, J STRUCT BIOL, V174, P11, DOI 10.1016/j.jsb.2010.11.021
   Osorio FG, 2016, INT REV CEL MOL BIO, V326, P133, DOI 10.1016/bs.ircmb.2016.04.003
   Paul M, 2006, PHYSIOL REV, V86, P747, DOI 10.1152/physrev.00036.2005
   Pescatello LS, 1999, ACSMS HEALTH FIT J, V3, P15, DOI 10.1249/00135124-199903000-00013
   Pyrc K, 2007, EXPERT REV ANTI-INFE, V5, P245, DOI 10.1586/14787210.5.2.245
   Rao G.H.R., 2018, J. Clin Prevent Cardiol, V7, P22, DOI 10.4103/JCPC.JCPC4117
   Rawal G, 2016, J CRIT CARE MED, V2, P109, DOI 10.1515/jccm-2016-0017
   Reinelt P, 2001, INTENS CARE MED, V27, P1466, DOI 10.1007/s001340101043
   Roback JD, 2020, JAMA-J AM MED ASSOC, V323, P1561, DOI 10.1001/jama.2020.4940
   Roohani N, 2013, J RES MED SCI, V18, P144
   Sahoo S, 2016, CLIN SCI, V130, P317, DOI 10.1042/CS20150087
   Sano M, 2018, J CARDIOL, V71, P471, DOI 10.1016/j.jjcc.2017.12.004
   Schaufelberger M, 1998, J Card Fail, V4, P185, DOI 10.1016/S1071-9164(98)80005-5
   Sowers J R, 2001, Clin Cornerstone, V4, P17, DOI 10.1016/S1098-3597(01)90026-2
   Stene LC, 2012, CLIN EXP IMMUNOL, V168, P12, DOI 10.1111/j.1365-2249.2011.04555.x
   Tchkonia T, 2013, J CLIN INVEST, V123, P966, DOI 10.1172/JCI64098
   Tiberti C, 2000, DIABETES-METAB RES, V16, P8, DOI 10.1002/(SICI)1520-7560(200001/02)16:1<8::AID-DMRR77>3.3.CO;2-K
   Tikellis C, 2012, CLIN SCI, V123, P519, DOI 10.1042/CS20110668
   Tousoulis D, 2006, CYTOKINE GROWTH F R, V17, P225, DOI 10.1016/j.cytogfr.2006.04.003
   Tu WJ, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.02111
   Vaduganathan M, 2020, NEW ENGL J MED, V382, P1653, DOI 10.1056/NEJMsr2005760
   Vasudevan Abu R, 2005, Clin Cornerstone, V7, P7, DOI 10.1016/S1098-3597(05)80063-8
   Wang ML, 2020, CELL RES, V30, P269, DOI 10.1038/s41422-020-0282-0
   Welsh KJ, 2016, DIABETES CARE, V39, P1299, DOI 10.2337/dc15-2727
   Wernery U, 2016, REV SCI TECH OIE, V35, P191, DOI 10.20506/rst.35.1.2427
   Yang JK, 2010, ACTA DIABETOL, V47, P193, DOI 10.1007/s00592-009-0109-4
   ZENG JH, 2020, INFECTION
   Zhang C, 2010, P NATL ACAD SCI USA, V107, P15886, DOI 10.1073/pnas.1001253107
   Zheng YY, 2020, NAT REV CARDIOL, V17, P259, DOI 10.1038/s41569-020-0360-5
NR 88
TC 10
Z9 10
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1279-7707
EI 1760-4788
J9 J NUTR HEALTH AGING
JI J. Nutr. Health Aging
PD JUN
PY 2020
VL 24
IS 6
BP 550
EP 559
DI 10.1007/s12603-020-1385-5
EA MAY 2020
PG 10
WC Geriatrics & Gerontology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Nutrition & Dietetics
GA LV8QD
UT WOS:000532083400005
PM 32510105
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Nasi, M
   Patrizi, G
   Pizzi, C
   Landolfo, M
   Boriani, G
   Dei Cas, A
   Cicero, AFG
   Fogacci, F
   Rapezzi, C
   Sisca, G
   Capucci, A
   Vitolo, M
   Galiè, N
   Borghi, C
   Berrettini, U
   Piepoli, M
   Mattioli, AV
AF Nasi, Milena
   Patrizi, Giampiero
   Pizzi, Carmine
   Landolfo, Matteo
   Boriani, Giuseppe
   Dei Cas, Alessandra
   Cicero, Arrigo F. G.
   Fogacci, Federica
   Rapezzi, Claudio
   Sisca, Giovanbattista
   Capucci, Alessandro
   Vitolo, Marco
   Galie, Nazzareno
   Borghi, Claudio
   Berrettini, Umberto
   Piepoli, Massimo
   Mattioli, Anna V.
TI The role of physical activity in individuals with cardiovascular risk
   factors: an opinion paper from Italian Society of Cardiology-Emilia
   Romagna-Marche and SIC-Sport
SO JOURNAL OF CARDIOVASCULAR MEDICINE
LA English
DT Review
DE cardiovascular risk factors; diabetes; hypertension; physical activity;
   uric acid
ID SERUM URIC-ACID; BLOOD-PRESSURE; AEROBIC EXERCISE; WEIGHT-LOSS;
   ENDOTHELIAL FUNCTION; DISEASE; MORTALITY; OBESITY; METAANALYSIS;
   POPULATION
AB Regular physical activity is a cornerstone in the prevention and treatment of atherosclerotic cardiovascular disease (CVD) due to its positive effects in reducing several cardiovascular risk factors. Current guidelines on CVD suggest for healthy adults to perform at least 150 min/week of moderate intensity or 75 min/week of vigorous intensity aerobic physical activity. The current review explores the effects of physical activity on some risk factors, specifically: diabetes, dyslipidemia, hypertension and hyperuricemia. Physical activity induces an improvement in insulin sensitivity and in glucose control independently of weight loss, which may further contribute to ameliorate both diabetes-associated defects. The benefits of adherence to physical activity have recently proven to extend beyond surrogate markers of metabolic syndrome and diabetes by reducing hard endpoints such as mortality. In recent years, obesity has greatly increased in all countries. Weight losses in these patients have been associated with improvements in many cardiometabolic risk factors. Strategies against obesity included caloric restriction, however greater results have been obtained with association of diet and physical activity. Similarly, the beneficial effect of training on blood pressure via its action on sympathetic activity and on other factors such as improvement of endothelial function and reduction of oxidative stress can have played a role in preventing hypertension development in active subjects. The main international guidelines on prevention of CVD suggest to encourage and to increase physical activity to improve lipid pattern, hypertension and others cardiovascular risk factor. An active action is required to the National Society of Cardiology together with the Italian Society of Sports Cardiology to improve the prescription of organized physical activity in patients with CVD and/or cardiovascular risk factors.
C1 [Nasi, Milena; Mattioli, Anna V.] Univ Modena & Reggio Emilia, Dept Surg Med & Dent, Dept Morphol Sci Related Transplant Oncol & Regen, Modena, Italy.
   [Patrizi, Giampiero] Carpi Hosp, Dept Cardiol, Carpi, Italy.
   [Pizzi, Carmine; Rapezzi, Claudio; Galie, Nazzareno] Alma Mater Studiorum, Dept Expt Diagnost & Specialty Med DIMES, Bologna, Italy.
   [Landolfo, Matteo; Cicero, Arrigo F. G.; Fogacci, Federica; Borghi, Claudio] Univ Bologna, Dept Med & Surg Sci, Bologna, Italy.
   [Boriani, Giuseppe; Vitolo, Marco] Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, Div Cardiol, Modena, Italy.
   [Dei Cas, Alessandra] Univ Parma, Dept Clin & Expt Med, Endocrinol & Metab, Parma, Italy.
   [Sisca, Giovanbattista] Bologna FC, Bologna, Italy.
   [Sisca, Giovanbattista] Isokinet Med Grp, FIFA Med Ctr Excellence, Bologna, Italy.
   [Capucci, Alessandro] Marche Polytech Univ, Ancona, Italy.
   [Berrettini, Umberto] Camerino Hosp, Dept Cardiol, Camerino, Italy.
   [Piepoli, Massimo] Guglielmo da Saliceto Hosp, Heart Failure Unit, Cardiol, Piacenza, Italy.
C3 Universita di Modena e Reggio Emilia; University of Bologna; Universita
   di Modena e Reggio Emilia; University of Parma; University Hospital of
   Parma; Marche Polytechnic University; Guglielmo da Saliceto Hospital
RP Mattioli, AV (corresponding author), Univ Modena & Reggio Emilia, Dept Surg Med Dent & Morphol Sci, Cardiovasc Dis, Via Pozzo 71, I-41124 Modena, Italy.
EM annavittoria.mattioli@unimore.it
RI Vitolo, Marco/W-1038-2019; Cicero, Arrigo/H-8244-2019; Nasi,
   Milena/J-4425-2016; Landolfo, Matteo/MHQ-2733-2025; Boriani,
   Giuseppe/AAC-3406-2022; PIZZI, Carmine/C-8394-2012; Fogacci,
   Federica/R-5931-2016; BORIANI, GIUSEPPE/A-4852-2015; Mattioli, Anna
   Vittoria/G-6001-2012; Piepoli, Massimo/J-9437-2016
OI BORIANI, GIUSEPPE/0000-0002-9820-4815; Mattioli, Anna
   Vittoria/0000-0003-1487-9530; Vitolo, Marco/0000-0002-5196-6249;
   Landolfo, Matteo/0000-0002-2087-2573; Pizzi,
   Carmine/0000-0002-4048-675X; Piepoli, Massimo/0000-0003-1124-234X;
   Cicero, Arrigo Francesco Giuseppe/0000-0002-4367-3884; Dei Cas,
   Alessandra/0000-0002-8666-4849
CR Alenazi AM, 2018, J ALTERN COMPLEM MED, V24, P220, DOI 10.1089/acm.2017.0104
   Amer Diabet Assoc, 2018, DIABETES CARE, V41, pS38, DOI 10.2337/dc18-S004
   [Anonymous], 2011, ATHEROSCLEROSIS S1
   Arnett DK, 2019, CIRCULATION, V140, pE563, DOI [10.1016/j.jacc.2019.03.009, 10.1016/j.jacc.2019.03.010, 10.1161/CIR.0000000000000678, 10.1161/CIR.0000000000000677]
   Bergsbaken T, 2009, NAT REV MICROBIOL, V7, P99, DOI 10.1038/nrmicro2070
   Bird Stephen R, 2016, BMJ Open Sport Exerc Med, V2, pe000143, DOI 10.1136/bmjsem-2016-000143
   Biswas A, 2015, ANN INTERN MED, V162, P123, DOI 10.7326/M14-1651
   Bordin P, 2018, J CARDIOVASC MED, V19, P422, DOI 10.2459/JCM.0000000000000682
   Borghi C, 2017, HYPERTENSION, V69, P1011, DOI 10.1161/HYPERTENSIONAHA.117.09081
   Borghi C, 2015, J HYPERTENS, V33, P1729, DOI 10.1097/HJH.0000000000000701
   Bove M, 2017, CURR HYPERTENS REP, V19, DOI 10.1007/s11906-017-0793-3
   Cai M, 2016, OBES RES CLIN PRACT, V10, P589, DOI 10.1016/j.orcp.2015.10.010
   Cesa CC, 2014, PREV MED, V69, P54, DOI 10.1016/j.ypmed.2014.08.014
   Chudyk A, 2011, DIABETES CARE, V34, P1228, DOI 10.2337/dc10-1881
   Cicero AFG, 2017, ANN MED, V49, P275, DOI 10.1080/07853890.2016.1222451
   Cicero AFG, 2017, EUR J INTERN MED, V37, P38, DOI 10.1016/j.ejim.2016.07.026
   Cornelissen VA, 2011, HYPERTENSION, V58, P950, DOI 10.1161/HYPERTENSIONAHA.111.177071
   Cossarizza A, 2014, IMMUNOL LETT, V162, P279, DOI 10.1016/j.imlet.2014.09.003
   Deanfield JE, 2007, CIRCULATION, V115, P1285, DOI 10.1161/CIRCULATIONAHA.106.652859
   Dempsey PC, 2016, DIABETES CARE, V39, P964, DOI 10.2337/dc15-2336
   Donnelly JE, 2009, MED SCI SPORT EXER, V41, P459, DOI 10.1249/MSS.0b013e3181949333
   Edwards N, 2018, FRONT MED-LAUSANNE, V5, DOI 10.3389/fmed.2018.00200
   Ekblom-Bak E, 2018, EUR J PREV CARDIOL, V25, P309, DOI 10.1177/2047487317745177
   Ekelund U, 2015, AM J CLIN NUTR, V101, P613, DOI 10.3945/ajcn.114.100065
   Feig DI, 2008, JAMA-J AM MED ASSOC, V300, P924, DOI 10.1001/jama.300.8.924
   Fiorentino TV, 2018, ACTA DIABETOL, V55, P835, DOI 10.1007/s00592-018-1153-8
   Garcia-Hermoso A, 2018, BRIT J SPORT MED, V52, P161, DOI 10.1136/bjsports-2016-096605
   Gimbrone MA, 2016, CIRC RES, V118, P620, DOI 10.1161/CIRCRESAHA.115.306301
   Greaves David R., 2001, Trends in Immunology, V22, P180, DOI 10.1016/S1471-4906(00)01848-2
   Gui YJ, 2017, EUR J PREV CARDIOL, V24, P907, DOI 10.1177/2047487317691874
   Hoffmann MM, 2018, CURR CARDIOL REP, V20, DOI 10.1007/s11886-018-0996-5
   Hu FB, 2004, NEW ENGL J MED, V351, P2694, DOI 10.1056/NEJMoa042135
   Huh JY, 2018, ARCH PHARM RES, V41, P14, DOI 10.1007/s12272-017-0994-y
   Joyner MJ, 2015, PHYSIOL REV, V95, P549, DOI 10.1152/physrev.00035.2013
   Katsiki N, 2013, J CARDIOVASC MED, V14, P397, DOI 10.2459/JCM.0b013e3283595adc
   Kelley GA, 2012, CLIN NUTR, V31, P156, DOI 10.1016/j.clnu.2011.11.011
   Kim SY, 2010, ARTHRIT CARE RES, V62, P170, DOI 10.1002/acr.20065
   Kitta Y, 2009, J AM COLL CARDIOL, V53, P323, DOI 10.1016/j.jacc.2008.08.074
   Klein S, 2004, CIRCULATION, V110, P2952, DOI 10.1161/01.CIR.0000145546.97738.1E
   Koster A, 2009, AM J EPIDEMIOL, V169, P1344, DOI 10.1093/aje/kwp053
   Kotani Kazuhiko, 2012, J Clin Med Res, V4, P161, DOI 10.4021/jocmr870w
   Kraus E, 2018, JBJS REV, V6, DOI 10.2106/JBJS.RVW.17.00205
   Kuhle CL, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2014-005283
   Kuo CF, 2015, ANN RHEUM DIS, V74, P661, DOI 10.1136/annrheumdis-2013-204463
   La Gerche A, 2014, CIRCULATION, V130, P992, DOI 10.1161/CIRCULATIONAHA.114.008141
   Larsen MK, 2016, MEDICINA-LITHUANIA, V52, P19, DOI 10.1016/j.medici.2016.01.005
   Lavie CJ, 2009, J AM COLL CARDIOL, V53, P1925, DOI 10.1016/j.jacc.2008.12.068
   Lin XC, 2015, J AM HEART ASSOC, V4, DOI 10.1161/JAHA.115.002014
   Mattioli AV, 2017, J CARDIOVASC MED, V18, P925, DOI 10.2459/JCM.0000000000000573
   Mattioli AV, 2018, J CARDIOVASC MED, V19, P677, DOI 10.2459/JCM.0000000000000714
   McGuire S, 2011, ADV NUTR, V2, P293, DOI 10.3945/an.111.000430
   Medlow P, 2016, FREE RADICAL RES, V50, P345, DOI 10.3109/10715762.2015.1109084
   Mudau M, 2012, CARDIOVASC J AFR, V23, DOI 10.5830/CVJA-2011-068
   Nasi M, 2017, CLIN EXP IMMUNOL, V187, P44, DOI 10.1111/cei.12814
   Nasi M, 2014, IMMUNOL LETT, V162, P329, DOI 10.1016/j.imlet.2014.06.012
   Oja P, 2018, BRIT J SPORT MED, V52, P769, DOI 10.1136/bjsports-2017-098558
   Oreopoulos A, 2008, OBESITY, V16, P442, DOI 10.1038/oby.2007.36
   Pan B, 2018, INT J BEHAV NUTR PHY, V15, DOI 10.1186/s12966-018-0703-3
   Paravicini TM, 2006, CARDIOVASC RES, V71, P247, DOI 10.1016/j.cardiores.2006.05.001
   Park KH, 2015, J KOREAN MED SCI, V30, P1213, DOI 10.3346/jkms.2015.30.9.1213
   Pedersen LR, 2016, ATHEROSCLEROSIS, V246, P221, DOI 10.1016/j.atherosclerosis.2016.01.001
   Piepoli MF, 2016, EUR HEART J, V37, P2315, DOI 10.1093/eurheartj/ehw106
   Qu LH, 2017, ANN MED, V49, P142, DOI 10.1080/07853890.2016.1243803
   Rajendran P, 2013, INT J BIOL SCI, V9, P1057, DOI 10.7150/ijbs.7502
   Roddy E, 2010, ARTHRITIS RES THER, V12, DOI 10.1186/ar3199
   Ross R, 2000, ANN INTERN MED, V133, P92, DOI 10.7326/0003-4819-133-2-200007180-00008
   Rubinshtein R, 2010, EUR HEART J, V31, P1142, DOI 10.1093/eurheartj/ehq010
   Rydén L, 2014, DIABETES VASC DIS RE, V11, P133, DOI 10.1177/1479164114525548
   Saladini F, 2017, J HYPERTENS, V35, P994, DOI 10.1097/HJH.0000000000001271
   Sciomer S, 2019, EUR J PREV CARDIOL, V26, P609, DOI 10.1177/2047487318810560
   Solomon TPJ, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00896
   Solomon TPJ, 2013, J CLIN ENDOCR METAB, V98, P4176, DOI 10.1210/jc.2013-2232
   Spence AL, 2013, J PHYSIOL-LONDON, V591, P1265, DOI 10.1113/jphysiol.2012.247387
   Spillmann F, 2014, ATHEROSCLEROSIS, V232, P1, DOI 10.1016/j.atherosclerosis.2013.10.001
   Teo SYM, 2018, MED SCI SPORT EXER, V50, P2387, DOI 10.1249/MSS.0000000000001732
   Thompson PD, 2003, ARTERIOSCL THROM VAS, V23, pE42, DOI 10.1161/01.ATV.0000089628.63625.D4
   Tomiyama H, 2018, HYPERTENSION, V72, P739, DOI 10.1161/HYPERTENSIONAHA.118.11390
   Trifiò G, 2013, ANN RHEUM DIS, V72, P694, DOI 10.1136/annrheumdis-2011-201254
   Wang J, 2014, PLOS ONE, V9, DOI [10.1371/journal.pone.0105125, 10.1371/journal.pone.0114259]
   Wang YT, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0515-5
   Warburton DER, 2016, CAN J CARDIOL, V32, P495, DOI 10.1016/j.cjca.2016.01.024
   Wen CP, 2011, LANCET, V378, P1244, DOI 10.1016/S0140-6736(11)60749-6
   Williams B, 2018, J HYPERTENS, V36, P2284, DOI [10.1097/HJH.0000000000001961, 10.1097/HJH.0000000000002026]
   Wing RR, 2010, ARCH INTERN MED, V170, P1566, DOI 10.1001/archinternmed.2010.334
   World Health Organization, 2019, World Health Organization
   Zhang CH, 2008, BASIC RES CARDIOL, V103, P398, DOI 10.1007/s00395-008-0733-0
   ,, 2010, Global recommendations on physical activity for health
NR 87
TC 50
Z9 50
U1 1
U2 31
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1558-2027
EI 1558-2035
J9 J CARDIOVASC MED
JI J. Cardiovasc. Med.
PD OCT
PY 2019
VL 20
IS 10
BP 631
EP 639
DI 10.2459/JCM.0000000000000855
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA IX2UB
UT WOS:000485543800002
PM 31436678
DA 2025-06-11
ER

PT J
AU Sharma, H
   Chandola, HM
AF Sharma, Hari
   Chandola, H. M.
TI Prameha in Ayurveda: Correlation with Obesity, Metabolic
   Syndrome, and Diabetes Mellitus. Part 2-Management of Prameha
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
ID ENICOSTEMMA-LITTORALE BLUME; TINOSPORA-CORDIFOLIA ROOTS; INDIAN
   MEDICINAL-PLANTS; TURMERIC CURCUMA-LONGA; GARLIC POWDER TABLETS;
   BLOOD-GLUCOSE LEVEL; GYMNEMA-SYLVESTRE; OXIDATIVE STRESS;
   MOMORDICA-CHARANTIA; AQUEOUS EXTRACT
AB Background: Obesity, metabolic syndrome, and diabetes mellitus are increasing to epidemic proportions globally. Prameha is a syndrome described in the ancient Ayurvedic texts that includes clinical conditions involved in obesity, prediabetes, diabetes mellitus, and metabolic syndrome.
   Materials and methods: Various dietary, lifestyle, and psychologic factors are involved in the etiology of Prameha, particularly in relation to disturbances in fat and carbohydrate metabolism.
   Results: The Ayurvedic management of Prameha emphasizes dietary and lifestyle recommendations and herbal preparations, in accordance with the psychophysiologic constitution of the patient. Ayurveda also addresses the management of psychologic factors that contribute to the development of Prameha. Ayurvedic treatment known as Apatarpana (balanced diet with restricted calories) and Santarpana (highly nutritious, high-calorie diet intended to increase weight) are recommended for patients with type 2 and type 1 diabetes, respectively. Various Ayurvedic herbs and herbomineral formulations are utilized, based on the stage and type of disease as well as the psychophysiologic constitution of the patient. A large body of research has been conducted on these Ayurvedic herbs.
   Conclusions: Integrating the theory and modalities of Ayurveda in the management of these disorders may prove to be beneficial.
C1 [Sharma, Hari] Ohio State Univ, Coll Med, Ctr Integrat Med, Columbus, OH 43221 USA.
   [Sharma, Hari] Ohio State Univ, Coll Med, Dept Pathol, Columbus, OH 43221 USA.
   [Chandola, H. M.] Gujarat Ayurved Univ, Inst Postgrad Teaching & Res Ayurveda, Jamnagar, India.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University
RP Sharma, H (corresponding author), Ohio State Univ, Coll Med, Ctr Integrat Med, 2000 Kenny Rd, Columbus, OH 43221 USA.
EM sharma.2@osu.edu
CR Abdel-Magied EM, 2001, J ETHNOPHARMACOL, V75, P1, DOI 10.1016/S0378-8741(00)00348-2
   ACHARYA VJT, 2005, SUSHRUTA SAMHITA, P456
   ACHARYA VJT, 2004, AGNIVESHA CHARAKA SA
   Agarwal SP, 2007, PHYTOTHER RES, V21, P401, DOI 10.1002/ptr.2100
   Aggarwal BB, 2009, INT J BIOCHEM CELL B, V41, P40, DOI 10.1016/j.biocel.2008.06.010
   Ahmad I, 1998, J ETHNOPHARMACOL, V62, P183, DOI 10.1016/S0378-8741(98)00055-5
   AKHTAR MS, 1981, PLANTA MED, V42, P205, DOI 10.1055/s-2007-971629
   Amin A, 2006, ANN NY ACAD SCI, V1084, P391, DOI 10.1196/annals.1372.005
   Amin K. M. Y., 1996, Fitoterapia, V67, P53
   Anand R., 1994, Indian Journal of Experimental Biology, V32, P548
   Anantha Kumar K.V., 1994, Indian Drugs, V31, P321
   Annida B, 2005, J MED FOOD, V8, P382, DOI 10.1089/jmf.2005.8.382
   Babu PS, 1997, MOL CELL BIOCHEM, V166, P169, DOI 10.1023/A:1006819605211
   BAJPAI MB, 1991, PLANTA MED, V57, P102, DOI 10.1055/s-2006-960041
   Ballal M., 2000, Indian Journal of Pharmacology, V32, P392
   Bapat S K, 1969, Indian J Physiol Pharmacol, V13, P189
   Barclay AW, 2008, AM J CLIN NUTR, V87, P627, DOI 10.1093/ajcn/87.3.627
   BASKARAN K, 1990, J ETHNOPHARMACOL, V30, P295, DOI 10.1016/0378-8741(90)90108-6
   Behall KM, 2006, NUTR RES, V26, P644, DOI 10.1016/j.nutres.2006.10.001
   Belska NV, 2010, INT IMMUNOPHARMACOL, V10, P933, DOI 10.1016/j.intimp.2010.05.005
   BHATTACHARYA SK, 1995, PHYTOTHER RES, V9, P41, DOI 10.1002/ptr.2650090110
   Bihaqi SW, 2009, J ETHNOPHARMACOL, V124, P409, DOI 10.1016/j.jep.2009.05.038
   Bijlani RL, 2005, J ALTERN COMPLEM MED, V11, P267, DOI 10.1089/acm.2005.11.267
   Bordia A, 1998, PROSTAG LEUKOTR ESS, V58, P257, DOI 10.1016/S0952-3278(98)90034-5
   Calabrese C, 2008, J ALTERN COMPLEM MED, V14, P707, DOI 10.1089/acm.2008.0018
   Casiraghi MC, 2006, J AM COLL NUTR, V25, P313, DOI 10.1080/07315724.2006.10719541
   Chandola H. M., 1980, J RES AYURVEDA SIDDH, V1, P345
   CHANDOLA HM, 1984, DIABETES MELLITUS DE, P383
   CHANDRASEKAR B, 1990, INDIAN J EXP BIOL, V28, P616
   Chaturvedi P, 2005, BRIT J BIOMED SCI, V62, P124, DOI 10.1080/09674845.2005.11732698
   Chaturvedi P, 2010, J MED FOOD, V13, P520, DOI 10.1089/jmf.2009.0151
   Chithra V, 1999, INDIAN J BIOCHEM BIO, V36, P59
   Chithra V, 1997, PLANT FOOD HUM NUTR, V51, P167, DOI 10.1023/A:1007975430328
   DASA G, 2000, BHAISHAJYARATNAVALI
   DESHPANDE PJ, 1982, INDIAN J MED RES, V76, P46
   Devi BA, 2003, PHYTOTHER RES, V17, P1231, DOI 10.1002/ptr.1357
   Dhanasekaran M, 2009, PHYTOTHER RES, V23, P14, DOI 10.1002/ptr.2405
   Dhandapani S, 2002, PHARMACOL RES, V46, P251, DOI 10.1016/S1043-6618(02)00131-7
   Dhingra D, 2007, MED SCI MONITOR, V13, pBR155
   Dijsselbloem N, 2004, BIOCHEM PHARMACOL, V68, P1171, DOI 10.1016/j.bcp.2004.05.036
   Dwivedi S, 2005, INT J CARDIOL, V100, P507, DOI 10.1016/j.ijcard.2004.10.045
   DWIVEDI S, 1989, PHARM BIOL, V27, P217
   DWIVEDI S, 1987, INDIAN DRUGS, V24, P378
   Eidi A, 2006, PHYTOMEDICINE, V13, P624, DOI 10.1016/j.phymed.2005.09.010
   Fung TT, 2004, ARCH INTERN MED, V164, P2235, DOI 10.1001/archinte.164.20.2235
   Fung TT, 2002, AM J CLIN NUTR, V76, P535, DOI 10.1093/ajcn/76.3.535
   Gattu M, 1997, PHARMACOL BIOCHEM BE, V57, P793, DOI 10.1016/S0091-3057(96)00391-7
   Gauthaman K, 2005, J ETHNOPHARMACOL, V96, P403, DOI 10.1016/j.jep.2004.08.040
   Gholap S, 2003, PHARMAZIE, V58, P413
   Grover JK, 2002, J ETHNOPHARMACOL, V81, P81, DOI 10.1016/S0378-8741(02)00059-4
   Gupta A, 2001, J Assoc Physicians India, V49, P1057
   Hamden K, 2010, IMMUNOPHARM IMMUNOT, V32, P437, DOI 10.3109/08923970903490486
   Iyer A, 2009, INDIAN J BIOCHEM BIO, V46, P467
   Kar A, 2003, J ETHNOPHARMACOL, V84, P105, DOI 10.1016/S0378-8741(02)00144-7
   Kassaian N, 2009, INT J VITAM NUTR RES, V79, P34, DOI 10.1024/0300-9831.79.1.34
   Kavitha AV, 2006, J ENVIRON BIOL, V27, P397
   Kavitha D., 2004, Indian Journal of Experimental Biology, V42, P589
   Khan A, 2003, DIABETES CARE, V26, P3215, DOI 10.2337/diacare.26.12.3215
   Khosla P., 2000, Indian Journal of Physiology and Pharmacology, V44, P69
   Kochhar K P, 2008, Indian J Physiol Pharmacol, V52, P327
   Kochhar K P, 2008, Indian J Physiol Pharmacol, V52, P106
   Krishnaveni Mani, 2010, Journal of Basic and Clinical Physiology and Pharmacology, V21, P93
   Kulkarni SK, 2008, PROG NEURO-PSYCHOPH, V32, P1093, DOI 10.1016/j.pnpbp.2007.09.011
   Kumar MHV, 2003, CLIN EXP PHARMACOL P, V30, P336, DOI 10.1046/j.1440-1681.2003.03842.x
   Kumar MHV, 2002, PHYTOMEDICINE, V9, P302, DOI 10.1078/0944-7113-00136
   Kumar V, 2006, PHYTOTHER RES, V20, P1023, DOI 10.1002/ptr.1970
   Kyizom T, 2010, INDIAN J MED RES, V131, P636
   Lampe JW, 2003, AM J CLIN NUTR, V78, p579S, DOI 10.1093/ajcn/78.3.579S
   Leach MJ, 2007, J ALTERN COMPLEM MED, V13, P977, DOI 10.1089/acm.2006.6387
   Malhotra Varun, 2005, Nepal Med Coll J, V7, P145
   Malhotra Varun, 2002, Indian Journal of Physiology and Pharmacology, V46, P313
   Malhotra Varun, 2002, Indian Journal of Physiology and Pharmacology, V46, P298
   Mathew J, 2010, EPILEPSY BEHAV, V17, P441, DOI 10.1016/j.yebeh.2010.01.012
   Mazumder R, 2006, PHYTOTHER RES, V20, P82, DOI 10.1002/ptr.1804
   McKeown NM, 2004, DIABETES CARE, V27, P538, DOI 10.2337/diacare.27.2.538
   Micha R, 2010, CIRCULATION, V121, P2271, DOI 10.1161/CIRCULATIONAHA.109.924977
   Miller A L, 1998, Altern Med Rev, V3, P422
   MISHRA B, 2000, CHAUKHAMBHA SANSKRIT, P606
   Mishra L C, 2000, Altern Med Rev, V5, P334
   MUDGAL V, 1977, J RES INDIAN MED YOG, V12, P127
   Mukherjee PK, 2007, PLANTA MED, V73, P283, DOI 10.1055/s-2007-967114
   Murugan P, 2006, BASIC CLIN PHARMACOL, V99, P122, DOI 10.1111/j.1742-7843.2006.pto_447.x
   Nilsson AC, 2008, J NUTR, V138, P732, DOI 10.1093/jn/138.4.732
   Nilsson AC, 2010, J NUTR, V140, P1932, DOI 10.3945/jn.110.123604
   Nishiyama T, 2005, J AGR FOOD CHEM, V53, P959, DOI 10.1021/jf0483873
   PARADKAR BH, 2000, VAGBHATAS ASHTANGA H
   PATEL V, 1982, ACTIV NERV SUPER, P387
   Prasad K.V.S.R.G., 2007, PHCOG REV, V1, P175
   Prince Ponnaian Stanley Mainzen, 2005, Acta Pol Pharm, V62, P363
   Prince PSM, 2003, PHYTOTHER RES, V17, P410, DOI 10.1002/ptr.1130
   Prince PSM, 2001, PHYTOTHER RES, V15, P213, DOI 10.1002/ptr.707
   Prince PSM, 1999, J ETHNOPHARMACOL, V64, P53, DOI 10.1016/S0378-8741(98)00106-8
   Quiles JL, 2002, ARTERIOSCL THROM VAS, V22, P1225, DOI 10.1161/01.ATV.0000020676.11586.F2
   RAO MVR, 1973, J RES INDIAN MED, V8, P9
   Rao TP, 2005, J MED FOOD, V8, P362, DOI 10.1089/jmf.2005.8.362
   Ravindran P., 2007, TURMERIC GENUS CURCU
   Rawal Avinash K, 2004, BMC Complement Altern Med, V4, P11, DOI 10.1186/1472-6882-4-11
   Sabu MC, 2009, INDIAN J EXP BIOL, V47, P270
   Sabu MC, 2002, J ETHNOPHARMACOL, V81, P155, DOI 10.1016/S0378-8741(02)00034-X
   Saxena A, 2004, J ALTERN COMPLEM MED, V10, P369, DOI 10.1089/107555304323062365
   SAXENA A M, 1991, Indian Journal of Experimental Biology, V29, P674
   Saxena Anand Murari, 1993, Indian Journal of Experimental Biology, V31, P178
   Saxena N, 2003, DIABETES CARE, V26, P2469, DOI 10.2337/diacare.26.8.2469-a
   Schulze MB, 2003, DIABETOLOGIA, V46, P1465, DOI 10.1007/s00125-003-1220-7
   SEKAR BC, 1987, J ETHNOPHARMACOL, V21, P175, DOI 10.1016/0378-8741(87)90127-9
   SHANMUGASUNDARAM ERB, 1990, J ETHNOPHARMACOL, V30, P281, DOI 10.1016/0378-8741(90)90107-5
   SHANMUGASUNDARAM ERB, 1990, J ETHNOPHARMACOL, V30, P265, DOI 10.1016/0378-8741(90)90106-4
   Sharma H., 1998, Contemporary Ayurveda"
   Sharma H, 2007, J ALTERN COMPLEM MED, V13, P1135, DOI 10.1089/acm.2007.7017-B
   Sharma H, 2007, J ALTERN COMPLEM MED, V13, P1011, DOI 10.1089/acm.2007.7017-A
   Sharma H, 2011, J ALTERN COMPLEM MED, V17, P549, DOI 10.1089/acm.2010.0690
   Sharma H, 2011, J ALTERN COMPLEM MED, V17, P491, DOI 10.1089/acm.2010.0396
   SHARMA KR, 1992, ANN OPHTHALMOL, V24, P5
   SHARMA PV, 2004, PRIYA NIGHANTU, P101
   SHARMA RD, 1990, EUR J CLIN NUTR, V44, P301
   Shastri A., 2003, SUSHRUTA SAMHITA AYU
   Shastri K.N., 2004, AGNIVESHA CHARAKA SA
   Shetty AK, 2005, PLANT FOOD HUM NUTR, V60, P109, DOI 10.1007/s11130-005-6837-x
   Shukla PK, 2006, HUM EXP TOXICOL, V25, P187, DOI 10.1191/0960327106ht613oa
   Si MM, 2010, J ETHNOPHARMACOL, V128, P154, DOI 10.1016/j.jep.2009.12.044
   Singh R.G., 1991, J RES EDN IND MED, V10, P19
   Singh R.H., 1972, J. Res. Ind. Med, V7, P28
   Singh R H, 1979, J RES INDIAN MED YOG, V14, P1
   Singh R. P., 1993, International Journal of Pharmacognosy, V31, P147
   Singh R.P., 1992, J IND MED RES, V11, P29
   Singh R, 2008, BIOGERONTOLOGY, V9, P369, DOI 10.1007/s10522-008-9185-z
   Singh Savita, 2004, J Assoc Physicians India, V52, P203
   Sobenin IA, 2008, ACTA DIABETOL, V45, P1, DOI 10.1007/s00592-007-0011-x
   Sobenin IA, 2008, J ATHEROSCLER THROMB, V15, P334, DOI 10.5551/jat.E550
   Sonawane RD, 2010, MOL CELL BIOCHEM, V340, P1, DOI 10.1007/s11010-010-0393-x
   Song Y, 2004, DIABETES CARE, V27, P2108, DOI 10.2337/diacare.27.9.2108
   Soumyanath A., 2006, Traditional Medicines For Modern Times: Antidiabetic Plants
   Stanely P, 2000, J ETHNOPHARMACOL, V70, P9, DOI 10.1016/S0378-8741(99)00136-1
   Strimpakos AS, 2008, ANTIOXID REDOX SIGN, V10, P511, DOI 10.1089/ars.2007.1769
   Suchalatha S., 2004, Indian Journal of Experimental Biology, V42, P174
   Suresh S, 2009, J ETHNOPHARMACOL, V122, P497, DOI 10.1016/j.jep.2009.01.032
   Tripathi S N., 1979, J.Res.Ind.Med.Yoga.Homeo, V14, P3
   Tripathi V., 1983, SACHITTAR AYURVEDA, V35, P733
   Trivedi N. A., 2004, Indian Journal of Pharmacology, V36, P373
   Uabundit N, 2010, J ETHNOPHARMACOL, V127, P26, DOI 10.1016/j.jep.2009.09.056
   Upadhyay UM, 2004, PHYTOTHER RES, V18, P233, DOI 10.1002/ptr.1434
   van Dam RM, 2002, DIABETES CARE, V25, P417, DOI 10.2337/diacare.25.3.417
   VARALAKSHMI P, 1990, J ETHNOPHARMACOL, V28, P313, DOI 10.1016/0378-8741(90)90082-5
   Vasu VT, 2005, J ETHNOPHARMACOL, V101, P277, DOI 10.1016/j.jep.2005.05.007
   VIJAYALAKSHMI K, 2002, AMRUTH, V6, P17
   Vinutha B, 2007, J ETHNOPHARMACOL, V109, P359, DOI 10.1016/j.jep.2006.06.014
   Virdi J, 2003, J ETHNOPHARMACOL, V88, P107, DOI 10.1016/S0378-8741(03)00184-3
   Vishwakarma SL, 2010, INDIAN J EXP BIOL, V48, P26
   Waheed Akbar, 2006, Pak J Pharm Sci, V19, P322
   Wu HS, 2009, J ETHNOPHARMACOL, V123, P288, DOI 10.1016/j.jep.2009.03.004
   Yokozawa T, 2007, BRIT J NUTR, V97, P1187, DOI 10.1017/S0007114507691971
   Zhou Y, 2007, J NAT PROD, V70, P652, DOI 10.1021/np060470s
   2000, SAHASRAYOGAM, P93
NR 153
TC 7
Z9 7
U1 0
U2 16
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
EI 1557-7708
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD JUL
PY 2011
VL 17
IS 7
BP 589
EP 599
DI 10.1089/acm.2010.0397
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 784UL
UT WOS:000292183600004
PM 21668351
DA 2025-06-11
ER

PT J
AU Orqueda, ME
   Rivas, M
   Zampini, IC
   Alberto, MR
   Torres, S
   Cuello, S
   Sayago, J
   Thomas-Valdes, S
   Jiménez-Aspee, F
   Schmeda-Hirschmann, G
   Isla, MI
AF Eugenia Orqueda, Maria
   Rivas, Marisa
   Catiana Zampini, Iris
   Rosa Alberto, Maria
   Torres, Sebastian
   Cuello, Soledad
   Sayago, Jorge
   Thomas-Valdes, Samanta
   Jimenez-Aspee, Felipe
   Schmeda-Hirschmann, Guillermo
   Ines Isla, Maria
TI Chemical and functional characterization of seed, pulp and skin powder
   from chilto (Solanum betaceum), an Argentine native fruit.
   Phenolic fractions affect key enzymes involved in metabolic syndrome and
   oxidative stress
SO FOOD CHEMISTRY
LA English
DT Article
DE Solanum betaceum; Chilto; Seed, pulp and skin powder; Antioxidant
   capacity; Metabolic syndrome
ID ANTIOXIDANT ACTIVITY; GEOFFROEA-DECORTICANS; TEA POLYPHENOLS; VITAMIN-C;
   IN-VITRO; TOMATO; CAV.; INHIBITORS; FLAVONOIDS; ANTHOCYANINS
AB The aim of this work was to assess the nutritional and functional components of powder obtained by lyophilization of whole fruits, seeds, pulp and skin from chilto (Solanum betaceum Cav) cultivated in the ecoregion of Yungas, Argentina. The powders have low carbohydrate and sodium content and are a source of vitamin C, carotenoid, phenolics, potassium and fiber. The HPLC-ESI-MS/MS analysis of the fractions enriched in phenolics allowed the identification of 12 caffeic acid derivatives and related phenolics, 10 rosmarinic acid derivatives and 7 flavonoids. The polyphenols enriched extracts before and after simulated gastroduodenal digestion inhibited enzymes associated with metabolic syndrome, including alpha-glucosidase, amylase and lipase and exhibited antioxidant activity by different mechanisms. None of the analyzed fruit powders showed acute toxicity or genotoxicity. The powders from the three parts of S. betaceum fruit may be a potential functional food and the polyphenol enriched extract of seed and skin may have nutraceutical properties. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Eugenia Orqueda, Maria; Rivas, Marisa; Catiana Zampini, Iris; Rosa Alberto, Maria; Torres, Sebastian; Cuello, Soledad; Sayago, Jorge; Ines Isla, Maria] Univ Nacl Tucuman, Fac Ciencias Nat, Inst Quim NOA INQUINOA CONICET, Lab Invest Prod Nat LIPRON, San Miguel De Tucuman, Argentina.
   [Eugenia Orqueda, Maria; Rivas, Marisa; Catiana Zampini, Iris; Rosa Alberto, Maria; Torres, Sebastian; Cuello, Soledad; Sayago, Jorge; Ines Isla, Maria] Univ Nacl Tucuman, IML, San Miguel De Tucuman, Argentina.
   [Thomas-Valdes, Samanta; Jimenez-Aspee, Felipe; Schmeda-Hirschmann, Guillermo] Univ Talca, Inst Quim Recursos Nat, Lab Quim Prod Nat, Casilla 747, Talca 3460000, Chile.
C3 Universidad Nacional de Tucuman; Universidad Nacional de Tucuman;
   Universidad de Talca
RP Isla, MI (corresponding author), Univ Nacl Tucuman, INQUINOA CONICET, San Lorenzo 1469, RA-4000 San Miguel De Tucuman, Tucuman, Argentina.
EM misla@tucbbs.com.ar
RI Torres, Sebastian/AAE-4510-2020; Thomas-Valdés, Samanta/H-4807-2018;
   Alberto, Maria Rosa/AAS-3062-2021; Sayago, Jorge/AAD-3546-2021; Schmeda
   Hirschmann, Guillermo/G-1046-2010; Jimenez Aspee, Felipe/G-6955-2017
OI Schmeda Hirschmann, Guillermo/0000-0002-9228-5378; Alberto, Maria
   Rosa/0000-0002-4173-9499; TORRES, Sebastian/0000-0002-3593-831X; Jimenez
   Aspee, Felipe/0000-0002-7285-7033
FU ARCOR Award to Technological Innovation (Argentina); Secretaria de
   Ciencia, Arte e Innovacion Tecnologica de la Universidad Nacional de
   Tucuman, Argentina (SCAIT-UNT); Consejo Nacional de Investigaciones
   Cientificas y Tecnicas, Argentina (CONICET); Agencia Nacional de
   Promocion Cientifica y Tecnologica, Argentina (ANPCyT); FONDECYT (Chile)
   [1120096]; PIEI-QUIM-BIO, Universidad de Talca
FX This research was supported by grants from: ARCOR Award to Technological
   Innovation (Argentina) in Edition 2015, Secretaria de Ciencia, Arte e
   Innovacion Tecnologica de la Universidad Nacional de Tucuman, Argentina
   (SCAIT-UNT), Consejo Nacional de Investigaciones Cientificas y Tecnicas,
   Argentina (CONICET), Agencia Nacional de Promocion Cientifica y
   Tecnologica, Argentina (ANPCyT), FONDECYT 1120096 (Chile) and
   PIEI-QUIM-BIO, Universidad de Talca.
CR Acosta-Quezada PG, 2015, FOOD CHEM, V169, P327, DOI 10.1016/j.foodchem.2014.07.152
   [Anonymous], 2005, Validation of analytical procedures: Text and methodology Q2 (R1)
   [Anonymous], 2005, AOAC International Official Methods of Analysis
   [Anonymous], 2016, DICT NATURAL PRODUCT
   AOAC, 2000, OFF METH AN CHEM
   Barros L, 2010, LWT-FOOD SCI TECHNOL, V43, P544, DOI 10.1016/j.lwt.2009.09.024
   Birari RB, 2007, DRUG DISCOV TODAY, V12, P879, DOI 10.1016/j.drudis.2007.07.024
   Chen Jinhu, 2014, Int J Endocrinol, V2014, P203930, DOI 10.1155/2014/203930
   Costamagna MS, 2016, FOOD CHEM, V190, P392, DOI 10.1016/j.foodchem.2015.05.068
   Costamagna MS, 2013, FOOD RES INT, V54, P160, DOI 10.1016/j.foodres.2013.05.038
   Espin S, 2016, FOOD CHEM, V194, P1073, DOI 10.1016/j.foodchem.2015.07.131
   GANCEDO MC, 1986, J FOOD SCI, V51, P571, DOI 10.1111/j.1365-2621.1986.tb13881.x
   Ghani U, 2015, EUR J MED CHEM, V103, P133, DOI 10.1016/j.ejmech.2015.08.043
   Gondoin A, 2010, FOOD RES INT, V43, P1537, DOI 10.1016/j.foodres.2010.04.029
   González-Castejón M, 2011, PHARMACOL RES, V64, P438, DOI 10.1016/j.phrs.2011.07.004
   Grau A, 2000, AMBIO, V29, P445, DOI 10.1639/0044-7447(2000)029[0445:DTTBAO]2.0.CO;2
   Grove KA, 2012, OBESITY, V20, P2311, DOI 10.1038/oby.2011.139
   Guil-Guerrero JL, 2009, J FOOD COMPOS ANAL, V22, P123, DOI 10.1016/j.jfca.2008.10.012
   Hurtado NH, 2009, FOOD CHEM, V117, P88, DOI 10.1016/j.foodchem.2009.03.081
   INOUE KH, 1988, ANAL BIOCHEM, V169, P363, DOI 10.1016/0003-2697(88)90296-5
   Isla MI, 2002, J ENZYM INHIB MED CH, V17, P37, DOI 10.1080/14756360290005570
   Jia Z, 1999, FOOD CHEM, V64, P555, DOI 10.1016/S0308-8146(98)00102-2
   Lee J, 2005, J AOAC INT, V88, P1269
   Levine M, 2001, P NATL ACAD SCI USA, V98, P9842, DOI 10.1073/pnas.171318198
   Liu CH, 2012, J INTEGR AGR, V11, P159, DOI 10.1016/S1671-2927(12)60794-9
   Manach C, 2004, AM J CLIN NUTR, V79, P727, DOI 10.1093/ajcn/79.5.727
   MARON DM, 1983, MUTAT RES, V113, P173, DOI 10.1016/0165-1161(83)90010-9
   McCue PP, 2004, ASIA PAC J CLIN NUTR, V13, P101
   Mendes L, 2011, FOOD CHEM TOXICOL, V49, P2285, DOI 10.1016/j.fct.2011.06.028
   Mertz C, 2010, FOOD CHEM, V119, P653, DOI 10.1016/j.foodchem.2009.07.009
   Mohamed G. A., 2014, Bulletin of the Faculty of Pharmacy, Cairo University, V52, P269, DOI 10.1016/j.bfopcu.2014.05.001
   Mohamed S, 2014, TRENDS FOOD SCI TECH, V35, P114, DOI 10.1016/j.tifs.2013.11.001
   Navarro-González I, 2011, FOOD RES INT, V44, P1528, DOI 10.1016/j.foodres.2011.04.005
   Ordóñez RM, 2005, POSTHARVEST BIOL TEC, V35, P293, DOI 10.1016/j.postharvbio.2004.09.006
   Ordóñez RM, 2006, PEPTIDES, V27, P1187, DOI 10.1016/j.peptides.2005.11.016
   Ordóñez RM, 2010, J AGR FOOD CHEM, V58, P331, DOI 10.1021/jf9024932
   Osorio C, 2012, FOOD CHEM, V132, P1915, DOI 10.1016/j.foodchem.2011.12.026
   Peluso I, 2015, BIOMED PHARMACOTHER, V71, P102, DOI 10.1016/j.biopha.2015.02.028
   Peng YY, 2008, J AGR FOOD CHEM, V56, P1838, DOI 10.1021/jf0727544
   Phillips KM, 2016, J FOOD COMPOS ANAL, V45, P147, DOI 10.1016/j.jfca.2015.09.008
   Prior RL, 2010, J SCI FOOD AGR, V90, P1473, DOI 10.1002/jsfa.3966
   Re R, 1999, FREE RADICAL BIO MED, V26, P1231, DOI 10.1016/S0891-5849(98)00315-3
   Rodriguez-Amaya D.B., 1999, A Guide to Carotenoid Analysis in Foods
   Rohn S, 2002, J AGR FOOD CHEM, V50, P3566, DOI 10.1021/jf011714b
   Rousselot D. B., 2004, TREAT ENDOCRINOL, V3, P41
   Schotsmans W. C., 2011, TAMARILLO SOLANUM BE
   Singleton VL, 1999, METHOD ENZYMOL, V299, P152
   Slimestad R, 2008, J AGR FOOD CHEM, V56, P2436, DOI 10.1021/jf073434n
   Svensson BM, 2005, ENVIRON MONIT ASSESS, V102, P309, DOI 10.1007/s10661-005-6029-z
   Tenore GC, 2015, FOOD CHEM, V169, P320, DOI 10.1016/j.foodchem.2014.08.006
   Toor RK, 2005, FOOD RES INT, V38, P487, DOI 10.1016/j.foodres.2004.10.016
   Torres CA, 2005, J AGR FOOD CHEM, V53, P9536, DOI 10.1021/jf051176t
   Usenik V, 2009, FOOD CHEM, V114, P529, DOI 10.1016/j.foodchem.2008.09.083
   Vasco C, 2008, FOOD CHEM, V111, P816, DOI 10.1016/j.foodchem.2008.04.054
   Vasco C, 2009, INT J FOOD SCI NUTR, V60, P278, DOI 10.1080/09637480903099618
   Vera de Rosso V, 2007, J AGR FOOD CHEM, V55, P9135, DOI 10.1021/jf071316u
   Wu SB, 2013, J CHROMATOGR A, V1314, P154, DOI 10.1016/j.chroma.2013.09.017
NR 57
TC 47
Z9 50
U1 2
U2 149
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0308-8146
EI 1873-7072
J9 FOOD CHEM
JI Food Chem.
PD FEB 1
PY 2017
VL 216
BP 70
EP 79
DI 10.1016/j.foodchem.2016.08.015
PG 10
WC Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology; Nutrition & Dietetics
GA DY0JO
UT WOS:000384783300010
PM 27596394
OA Green Published
DA 2025-06-11
ER

PT J
AU Murase, T
   Hattori, T
   Ohtake, M
   Nakashima, C
   Takatsu, M
   Murohara, T
   Nagata, K
AF Murase, Tamayo
   Hattori, Takuya
   Ohtake, Masafumi
   Nakashima, Chieko
   Takatsu, Miwa
   Murohara, Toyoaki
   Nagata, Kohzo
TI Effects of Estrogen on Cardiovascular Injury in Ovariectomized Female
   DahlS.Z-Lepr<SUP>fa</SUP>/Lepr<SUP>fa</SUP> Rats as a New
   Animal Model of Metabolic Syndrome
SO HYPERTENSION
LA English
DT Article
DE metabolic syndrome; estrogen; hypertension; myocardial fibrosis;
   diastolic dysfunction; oxidative stress; inflammation
ID ATTENUATES CARDIAC-HYPERTROPHY; LEFT-VENTRICULAR GEOMETRY;
   RENIN-ANGIOTENSIN SYSTEM; HEART-FAILURE; OXIDATIVE STRESS;
   BLOOD-PRESSURE; DIASTOLIC DYSFUNCTION; REPLACEMENT THERAPY; TYPE-1
   RECEPTOR; PLUS PROGESTIN
AB Although recent clinical trials have found an increased incidence of cardiovascular disease in women on estrogen replacement therapy, the underlying mechanism remains unclear. We have recently characterized DahlS.Z-Lepr(fa)/Lepr(fa) (DS/obese) rats, derived from a cross between Dahl salt-sensitive and Zucker rats, as a new animal model of metabolic syndrome. We have now examined the effects of estrogen replacement on cardiac pathophysiology in ovariectomized female DS/obese (Ovx-DS/obese) rats. Animals subjected to ovariectomy at 7 weeks of age were implanted subcutaneously with a 60-day release pellet containing 0.5 mg of 17 beta-estradiol (E-2) or placebo at 8 weeks. Age-matched female homozygous lean littermates (DahlS.Z-Lepr(+)/Lepr(+) or DS/lean rats) of DS/obese rats served as controls. Animals were maintained on a normal diet and were subjected to echocardiography followed by various pathological analyses at 13 weeks of age. Ovx-DS/obese rats manifested hypertension at 7 weeks of age and thereafter and showed left ventricular (LV) fibrosis and diastolic dysfunction at 13 weeks. Treatment with E-2 attenuated hypertension in Ovx-DS/obese rats but had no effect on blood pressure in ovariectomized female DS/lean (Ovx-DS/lean) rats. E-2 treatment exacerbated LV fibrosis and diastolic dysfunction, as well as further increased cardiac oxidative stress and inflammation in Ovx-DS/obese rats, and it elicited similar effects in Ovx-DS/lean rats. E-2 reduced food intake, body weight, and visceral fat content in both Ovx-DS/obese and Ovx-DS/lean rats. E-2 treatment attenuated hypertension and obesity but exacerbated LV fibrosis and diastolic dysfunction in Ovx-DS/obese rats, with these latter effects being associated with increased cardiac oxidative stress and inflammation. (Hypertension. 2012; 59: 694-704.). Online Data Supplement
C1 [Nakashima, Chieko; Nagata, Kohzo] Nagoya Univ, Sch Hlth Sci, Dept Med Technol, Higashi Ku, Nagoya, Aichi 4618673, Japan.
   [Murase, Tamayo; Hattori, Takuya; Ohtake, Masafumi; Takatsu, Miwa] Nagoya Univ, Grad Sch Med, Dept Pathophysiol, Lab Sci, Nagoya, Aichi 4648601, Japan.
   [Murase, Tamayo] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi 4648601, Japan.
C3 Nagoya University; Nagoya University; Nagoya University
RP Nagata, K (corresponding author), Nagoya Univ, Sch Hlth Sci, Dept Med Technol, Higashi Ku, 1-1-20 Daikominami, Nagoya, Aichi 4618673, Japan.
EM nagata@met.nagoya-u.ac.jp
RI Murohara, Toyoaki/M-4958-2014
FU Nippon Boehringer Ingelheim Co Ltd (Tokyo, Japan); Mochida
   Pharmaceutical Co Ltd (Tokyo, Japan); Japanese government
FX This work was supported by unrestricted research grants from Nippon
   Boehringer Ingelheim Co Ltd (Tokyo, Japan) and Mochida Pharmaceutical Co
   Ltd (Tokyo, Japan), as well as by Management Expenses Grants from the
   Japanese government to Nagoya University.
CR Ahmed MS, 2004, J MOL CELL CARDIOL, V36, P393, DOI 10.1016/j.yjmcc.2003.12.004
   CAMBOTTI LJ, 1984, AM J PHYSIOL, V247, pE258, DOI 10.1152/ajpendo.1984.247.2.E258
   Cid MC, 2002, ANN NY ACAD SCI, V966, P143, DOI 10.1111/j.1749-6632.2002.tb04211.x
   Curl CL, 2003, CLIN EXP PHARMACOL P, V30, P489, DOI 10.1046/j.1440-1681.2003.03864.x
   Cushman M, 2002, AM J CARDIOL, V90, p7F, DOI 10.1016/S0002-9149(02)02419-0
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   Dhuper S, 2011, OBESITY, V19, P128, DOI 10.1038/oby.2010.134
   Dias DP, BRAZ J MED BIOL RES, V43, P969
   Dubey RK, 2002, CARDIOVASC RES, V53, P688, DOI 10.1016/S0008-6363(01)00527-2
   Elmarakby AA, 2005, HYPERTENSION, V45, P283, DOI 10.1161/01.HYP.0000153051.56460.6a
   FARHAT MY, 1993, BRIT J PHARMACOL, V110, P719, DOI 10.1111/j.1476-5381.1993.tb13871.x
   Fisman EZ, 1999, MATURITAS, V33, P145, DOI 10.1016/S0378-5122(99)00051-1
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gao Q, 2007, NAT MED, V13, P89, DOI 10.1038/nm1525
   Gorodeski GI, 1995, AM J PHYSIOL-REG I, V269, pR1333, DOI 10.1152/ajpregu.1995.269.6.R1333
   Grohe C, 1996, STEROIDS, V61, P201, DOI 10.1016/0039-128X(96)00014-1
   Hattori T, 2011, NUTR DIABETES, V1, DOI 10.1038/nutd.2010.1
   HAYASHI T, 1992, P NATL ACAD SCI USA, V89, P11259, DOI 10.1073/pnas.89.23.11259
   Hulley S, 1998, JAMA-J AM MED ASSOC, V280, P605, DOI 10.1001/jama.280.7.605
   Kato MF, 2008, J HYPERTENS, V26, P1669, DOI 10.1097/HJH.0b013e328302f0f7
   Khalil RA, 2005, HYPERTENSION, V46, P249, DOI 10.1161/01.HYP.0000172945.06681.a4
   Koh KK, 2002, CARDIOVASC RES, V55, P714, DOI 10.1016/S0008-6363(02)00487-X
   Kuwahara F, 2004, HYPERTENSION, V43, P739, DOI 10.1161/01.HYP.0000118584.33350.7d
   Langrish JP, 2009, HYPERTENSION, V53, P805, DOI 10.1161/HYPERTENSIONAHA.108.126516
   Manson JE, 2003, NEW ENGL J MED, V349, P523, DOI 10.1056/NEJMoa030808
   Matsui H, 2008, HYPERTENSION, V52, P287, DOI 10.1161/HYPERTENSIONAHA.108.111815
   Mendelsohn ME, 1999, NEW ENGL J MED, V340, P1801, DOI 10.1056/NEJM199906103402306
   Miyachi M, 2009, HYPERTENSION, V53, P701, DOI 10.1161/HYPERTENSIONAHA.108.127290
   Miyata K, 2005, J AM SOC NEPHROL, V16, P2906, DOI 10.1681/ASN.2005040390
   Mueller Stefan O., 2001, Current Opinion in Pharmacology, V1, P613, DOI 10.1016/S1471-4892(01)00105-9
   Murase T, 2011, HYPERTENS RES
   Murase T, 2011, CARDIAC REMODELING D, DOI [10.1038/hr.2011.157, DOI 10.1038/HR.2011.157]
   Nagata K, 2006, HYPERTENSION, V47, P656, DOI 10.1161/01.HYP.0000203772.78696.67
   Nagata K, 2002, HYPERTENSION, V40, P168, DOI 10.1161/01.HYP.0000026668.50222.1E
   NAGATA K, 1995, J AM COLL CARDIOL, V25, P295, DOI 10.1016/0735-1097(94)00369-2
   Nagata K, 2008, CURR HYPERTENS REP, V10, P216, DOI 10.1007/s11906-008-0041-y
   Oestreicher EM, 2006, KIDNEY INT, V70, P1759, DOI 10.1038/sj.ki.5001897
   Pedram A, 2008, ENDOCRINOLOGY, V149, P3361, DOI 10.1210/en.2008-0133
   Pinto S, 1997, HYPERTENSION, V29, P268, DOI 10.1161/01.HYP.29.1.268
   Reffelmann T, 2003, BASIC RES CARDIOL, V98, P275, DOI 10.1007/s00395-003-0401-3
   Ren J, 2009, OBESITY, V17, P1114, DOI 10.1038/oby.2009.8
   Ricchiuti V, 2009, J ENDOCRINOL, V200, P75, DOI 10.1677/JOE-08-0199
   ROOKE GA, 1982, CIRC RES, V50, P273, DOI 10.1161/01.RES.50.2.273
   Sakata Y, 2004, CIRCULATION, V109, P2143, DOI 10.1161/01.CIR.0000125741.88712.77
   Sasaki T, 2000, J HYPERTENS, V18, P911, DOI 10.1097/00004872-200018070-00013
   Sawyer DB, 2002, J MOL CELL CARDIOL, V34, P379, DOI 10.1006/jmcc.2002.1526
   Schunkert H, 1997, CIRCULATION, V95, P39, DOI 10.1161/01.CIR.95.1.39
   Seely EW, 2004, CLIN ENDOCRINOL, V60, P315, DOI 10.1046/j.1365-2265.2004.01980.x
   Seshiah PN, 2002, CIRC RES, V91, P406, DOI 10.1161/01.RES.0000033523.08033.16
   Sharkey LC, 1999, J MOL CELL CARDIOL, V31, P1527, DOI 10.1006/jmcc.1999.0985
   Shinmura K, 2008, CARDIOVASC RES, V79, P387, DOI 10.1093/cvr/cvn086
   Somura F, 2001, CIRCULATION, V104, P658, DOI 10.1161/hc3101.093869
   Stier CT, 2003, AM J PHYSIOL-ENDOC M, V285, pE232, DOI 10.1152/ajpendo.00029.2003
   Wassmann S, 2001, CIRCULATION, V103, P435
   White RE, 2010, STEROIDS, V75, P788, DOI 10.1016/j.steroids.2009.12.007
   Xu JL, 2005, HYPERTENSION, V46, P719, DOI 10.1161/01.HYP.0000185189.46698.15
   Xu Y, 2003, CARDIOVASC RES, V57, P388, DOI 10.1016/S0008-6363(02)00705-8
   Yamada T, 2009, EUR J PHARMACOL, V615, P163, DOI 10.1016/j.ejphar.2009.05.028
   Yamaleyeva LM, 2007, AM J PHYSIOL-HEART C, V293, pH2064, DOI 10.1152/ajpheart.00427.2007
   Zhan E, 2008, EXP PHYSIOL, V93, P982, DOI 10.1113/expphysiol.2008.042788
   Zhou L, 2007, EUR J PHARMACOL, V567, P186, DOI 10.1016/j.ejphar.2007.03.047
NR 61
TC 31
Z9 32
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD MAR
PY 2012
VL 59
IS 3
BP 694
EP U369
DI 10.1161/HYPERTENSIONAHA.111.180976
PG 19
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 911KF
UT WOS:000301715000035
PM 22275535
OA Bronze
DA 2025-06-11
ER

PT J
AU Rubio-Ruiz, ME
   Guarner-Lans, V
   Pérez-Torres, I
   Soto, ME
AF Esther Rubio-Ruiz, Maria
   Guarner-Lans, Veronica
   Perez-Torres, Israel
   Elena Soto, Maria
TI Mechanisms Underlying Metabolic Syndrome-Related Sarcopenia and Possible
   Therapeutic Measures
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE sarcopenia; metabolic syndrome; skeletal muscle; obesity; sarcopenia
   treatment
ID SKELETAL-MUSCLE MASS; GLYCATION END-PRODUCTS; BIOAVAILABLE SERUM
   TESTOSTERONE; OVERLOAD-INDUCED HYPERTROPHY; RENIN-ANGIOTENSIN SYSTEM;
   NECROSIS-FACTOR-ALPHA; DIET-INDUCED OBESITY; INSULIN-RESISTANCE;
   BODY-COMPOSITION; VITAMIN-D
AB Although there are several reviews that report the interrelationship between sarcopenia and obesity and insulin resistance, the relation between sarcopenia and the other signs that compose the metabolic syndrome (MetS) has not been extensively revised. Here, we review the mechanisms underlying MetS-related sarcopenia and discuss the possible therapeutic measures proposed. A vicious cycle between the loss of muscle and the accumulation of intramuscular fat might be associated with MetS via a complex interplay of factors including nutritional intake, physical activity, body fat, oxidative stress, proinflammatory cytokines, insulin resistance, hormonal changes, and mitochondrial dysfunction. The enormous differences in lipid storage capacities between the two genders and elevated amounts of endogenous fat having lipotoxic effects that lead to the loss of muscle mass are discussed. The important repercussions of MetS-related sarcopenia on other illnesses that lead to increased disability, morbidity, and mortality are also addressed. Additional research is needed to better understand the pathophysiology of MetS-related sarcopenia and its consequences. Although there is currently no consensus on the treatment, lifestyle changes including diet and power exercise seem to be the best options.
C1 [Esther Rubio-Ruiz, Maria; Guarner-Lans, Veronica] Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Perez-Torres, Israel] Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Elena Soto, Maria] Inst Nacl Cardiol Ignacio Chavez, Dept Immunol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico; National Institute of Cardiology - Mexico
RP Guarner-Lans, V (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
EM esther.rubio@cardiologia.org.mx; veronica.guarner@cardiologia.org.mx;
   israel.perez@cardiologia.org.mx; elena.soto@cardiologia.org.mx
RI Pérez Torres, Israel/AAE-2579-2022; Guarner-Lans, Verónica/AFW-3723-2022
OI Guarner-Lans, Veronica/0000-0002-2655-7590; Perez-Torres,
   Israel/0000-0001-6510-2954; Soto, Maria Elena/0000-0003-1332-2888;
   Rubio-Ruiz, Maria Esther/0000-0002-8844-2078
CR Abate M, 2007, Eura Medicophys, V43, P407
   Abbott RD, 2007, NEUROLOGY, V68, P563, DOI 10.1212/01.wnl.0000254473.88647.ca
   Abós B, 2016, SCI REP-UK, V6, DOI 10.1038/srep30004
   Abrigo J, 2016, CELL PHYSIOL BIOCHEM, V40, P27, DOI 10.1159/000452522
   Akpan I, 2009, INT J OBESITY, V33, P1265, DOI 10.1038/ijo.2009.162
   Albrecht E, 2015, SCI REP-UK, V5, DOI 10.1038/srep08889
   Allan CA, 2007, INT J IMPOT RES, V19, P448, DOI 10.1038/sj.ijir.3901552
   Allen DL, 2011, MED SCI SPORT EXER, V43, P1828, DOI 10.1249/MSS.0b013e3182178bb4
   Anagnostis P, 2015, MATURITAS, V82, P56, DOI 10.1016/j.maturitas.2015.03.014
   Anand I, 1998, CARDIOVASC DRUG THER, V12, P291, DOI 10.1023/A:1007721917561
   Anderson EJ, 2009, J CLIN INVEST, V119, P573, DOI 10.1172/JCI37048
   [Anonymous], J GERONTOL A
   Baar K, 2004, P NUTR SOC, V63, P269, DOI 10.1079/PNS2004334
   Badin PM, 2011, DIABETES, V60, P1734, DOI 10.2337/db10-1364
   Bai HD, 2016, ASIA PAC J CLIN NUTR, V25, P326, DOI 10.6133/apjcn.2016.25.2.14
   Bale TL, 2003, ENDOCRINOLOGY, V144, P2580, DOI 10.1210/en.2002-0091
   Baltgalvis KA, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010164
   Barzilai N, 2010, J CLIN ENDOCR METAB, V95, P4493, DOI 10.1210/jc.2010-0859
   Bates B., 2011, National Diet and Nutrition Survey. Headline results from years 1 and 2 (combined) of the Rolling Programme (2008/2009 - 2009/10): Department of Health
   Batsis JA, 2018, NAT REV ENDOCRINOL, V14, P513, DOI 10.1038/s41574-018-0062-9
   Baumgartner RN, 1999, MECH AGEING DEV, V107, P123, DOI 10.1016/S0047-6374(98)00130-4
   Beaudart C, 2014, J CLIN ENDOCR METAB, V99, P4336, DOI 10.1210/jc.2014-1742
   Bhasin S, 2001, J ENDOCRINOL, V170, P27, DOI 10.1677/joe.0.1700027
   Bhasin S, 2001, AM J PHYSIOL-ENDOC M, V281, pE1172, DOI 10.1152/ajpendo.2001.281.6.E1172
   Biolo G, 2014, CLIN NUTR, V33, P737, DOI 10.1016/j.clnu.2014.03.007
   Bolster DR, 2002, J BIOL CHEM, V277, P23977, DOI 10.1074/jbc.C200171200
   Boström P, 2012, NATURE, V481, P463, DOI 10.1038/nature10777
   Bouchonville MF, 2013, CURR OPIN ENDOCRINOL, V20, P412, DOI 10.1097/01.med.0000433071.11466.7f
   Brodsky IG, 1996, J CLIN ENDOCR METAB, V81, P3469, DOI 10.1210/jc.81.10.3469
   Bruyère O, 2017, CURR OPIN CLIN NUTR, V20, P26, DOI 10.1097/MCO.0000000000000334
   Burne THJ, 2006, BRAIN RES BULL, V69, P74, DOI 10.1016/j.brainresbull.2005.10.014
   Cabello-Verrugio C, 2015, MED RES REV, V35, P437, DOI 10.1002/med.21343
   Campins L, 2017, PHARMACOLOGY, V99, P1, DOI 10.1159/000448247
   Cappola AR, 2001, J CLIN ENDOCR METAB, V86, P4139, DOI 10.1210/jc.86.9.4139
   Carson JA, 2015, BONE, V80, P67, DOI 10.1016/j.bone.2015.04.015
   Carter CS, 2005, J GERONTOL A-BIOL, V60, P1437, DOI 10.1093/gerona/60.11.1437
   Ceglia L, 2013, J CLIN ENDOCR METAB, V98, pE1927, DOI 10.1210/jc.2013-2820
   Chen A, 2006, P NATL ACAD SCI USA, V103, P16580, DOI 10.1073/pnas.0607337103
   Chu LW, 2008, J AM GERIATR SOC, V56, P1286, DOI 10.1111/j.1532-5415.2008.01746.x
   Clarkson PM, 2001, CURR OPIN CLIN NUTR, V4, P527, DOI 10.1097/00075197-200111000-00011
   Cleasby ME, 2016, J ENDOCRINOL, V229, pR67, DOI 10.1530/JOE-15-0533
   Comhaire F, 2016, ANDROLOGIA, V48, P65, DOI 10.1111/and.12419
   Conley KE, 2000, J PHYSIOL-LONDON, V526, P203, DOI 10.1111/j.1469-7793.2000.t01-1-00203.x
   Cuthbertson D, 2004, FASEB J, V18, P422, DOI 10.1096/fj.04-2640fje
   Dalal M, 2009, J GERONTOL A-BIOL, V64, P132, DOI 10.1093/gerona/gln018
   Dalton JT, 2011, J CACHEXIA SARCOPENI, V2, P153, DOI 10.1007/s13539-011-0034-6
   DANIEL SAJ, 1986, SEMIN REPROD ENDOCR, V4, P89, DOI 10.1055/s-2007-1022489
   DeFronzo RA, 2009, DIABETES CARE, V32, pS157, DOI 10.2337/dc09-S302
   DiBello JR, 2015, AGE AGEING, V44, P948, DOI 10.1093/ageing/afv129
   Dieli-Conwright CM, 2009, J APPL PHYSIOL, V107, P853, DOI 10.1152/japplphysiol.00404.2009
   Doherty TJ, 2003, J APPL PHYSIOL, V95, P1717, DOI 10.1152/japplphysiol.00347.2003
   Drummond MJ, 2008, CURR OPIN CLIN NUTR, V11, P222, DOI 10.1097/MCO.0b013e3282fa17fb
   Dutra MT, 2017, CLIN PHYSIOL FUNCT I, V37, P205, DOI 10.1111/cpf.12287
   Peredo-Escrcega AE, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/474032
   Endo I, 2003, ENDOCRINOLOGY, V144, P5138, DOI 10.1210/en.2003-0502
   Enns DL, 2010, SPORTS MED, V40, P41, DOI 10.2165/11319760-000000000-00000
   Feldman HA, 2002, J CLIN ENDOCR METAB, V87, P589, DOI 10.1210/jc.87.2.589
   Ferrando AA, 2002, AM J PHYSIOL-ENDOC M, V282, pE601, DOI 10.1152/ajpendo.00362.2001
   Ferreira I, 2004, J CLIN ENDOCR METAB, V89, P2632, DOI 10.1210/jc.2003-031619
   Florini JR, 1996, ENDOCR REV, V17, P481, DOI 10.1210/edrv-17-5-481
   Fujita S, 2007, DIABETES, V56, P1615, DOI 10.2337/db06-1566
   Fujita S, 2006, AM J PHYSIOL-ENDOC M, V291, pE745, DOI 10.1152/ajpendo.00271.2005
   Furuhashi M, 2008, NAT REV DRUG DISCOV, V7, P489, DOI 10.1038/nrd2589
   Morales MG, 2016, DIS MODEL MECH, V9, P441, DOI 10.1242/dmm.023390
   Gabriely I, 2002, DIABETES, V51, P2951, DOI 10.2337/diabetes.51.10.2951
   Gallagher D, 1997, J APPL PHYSIOL, V83, P229, DOI 10.1152/jappl.1997.83.1.229
   Gamboa JL, 2016, PHYSIOL REP, V4, DOI 10.14814/phy2.12780
   Gómez-Cabello A, 2012, NUTR HOSP, V27, P22, DOI [10.1590/S0212-16112012000100004, 10.3305/nh.2012.27.1.5502]
   Goodpaster BH, 2006, J GERONTOL A-BIOL, V61, P1059, DOI 10.1093/gerona/61.10.1059
   Griffiths RD, 1996, NUTRITION, V12, P456, DOI 10.1016/S0899-9007(96)00141-4
   Guillet C, 2004, J CLIN ENDOCR METAB, V89, P6017, DOI 10.1210/jc.2003-031323
   Guillet C, 2009, J CLIN ENDOCR METAB, V94, P3044, DOI 10.1210/jc.2008-2216
   Guo TQ, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004937
   Havekes B, 2010, CURR OPIN CLIN NUTR, V13, P641, DOI 10.1097/MCO.0b013e32833e341d
   Heber D, 1996, AM J CLIN NUTR, V64, P472
   Hermann M, 2001, EXP GERONTOL, V36, P1075, DOI 10.1016/S0531-5565(01)00113-9
   Hinkle RT, 2003, ENDOCRINOLOGY, V144, P4939, DOI 10.1210/en.2003-0271
   Holland WL, 2011, J CLIN INVEST, V121, P1858, DOI 10.1172/JCI43378
   Hori YS, 2011, J PHARMACOL EXP THER, V338, P784, DOI 10.1124/jpet.111.183210
   Horstman AM, 2012, J GERONTOL A-BIOL, V67, P1140, DOI 10.1093/gerona/gls068
   Iannuzzi-Sucich M, 2002, J GERONTOL A-BIOL, V57, pM772, DOI 10.1093/gerona/57.12.M772
   Ischaki E, 2007, CHEST, V132, P164, DOI 10.1378/chest.06-2789
   Jamieson PM, 2011, DIABETOLOGIA, V54, P2392, DOI 10.1007/s00125-011-2205-6
   Janssen I, 2004, J AM GERIATR SOC, V52, P80, DOI 10.1111/j.1532-5415.2004.52014.x
   Jensen GL, 2010, CURR OPIN CLIN NUTR, V13, P46, DOI 10.1097/MCO.0b013e32833309cf
   Kalinkovich A, 2017, AGEING RES REV, V35, P200, DOI 10.1016/j.arr.2016.09.008
   Katta A, 2010, AM J PHYSIOL-REG I, V299, pR1666, DOI 10.1152/ajpregu.00229.2010
   Kim G, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0659-2
   Kim TN, 2009, INT J OBESITY, V33, P885, DOI 10.1038/ijo.2009.130
   Kim Tae Nyun, 2013, J Bone Metab, V20, P1, DOI 10.11005/jbm.2013.20.1.1
   Kim TN, 2013, DIABETES RES CLIN PR, V101, P210, DOI 10.1016/j.diabres.2013.05.014
   Kim Y, 2018, J MED FOOD, V21, P551, DOI 10.1089/jmf.2017.4108
   Kob R, 2015, J CACHEXIA SARCOPENI, V6, P181, DOI 10.1002/jcsm.12019
   Krivickas LS, 2009, MUSCLE NERVE, V39, P3, DOI 10.1002/mus.21200
   Lafortuna CL, 2005, INT J OBESITY, V29, P833, DOI 10.1038/sj.ijo.0802955
   Law TD, 2016, ANNU REV GERONTOL GE, V36, P205, DOI 10.1891/0198-8794.36.205
   Le NH, 2014, MEDIAT INFLAMM, V2014, DOI 10.1155/2014/834294
   Leenders M, 2011, NUTR REV, V69, P675, DOI 10.1111/j.1753-4887.2011.00443.x
   LEXELL J, 1993, CAN J APPL PHYSIOL, V18, P2, DOI 10.1139/h93-002
   Lim JP, 2015, CLIN INTERV AGING, V10, P605, DOI 10.2147/CIA.S78901
   Liu CC, 2009, CLUSTER CHALLENGES IN BIOLOGICAL NETWORKS, P267, DOI 10.1142/9789812771667_0014
   Lu-Nguyen NB, 2015, MOL THER, V23, P1341, DOI 10.1038/mt.2015.88
   Makimura H, 2012, J CLIN ENDOCR METAB, V97, P4769, DOI 10.1210/jc.2012-2794
   Manini TM, 2012, J GERONTOL A-BIOL, V67, P28, DOI 10.1093/gerona/glr010
   Marcus Y, 2013, DIABETES, V62, P1121, DOI 10.2337/db12-0792
   Marini Mirca, 2008, Italian Journal of Anatomy and Embryology, V113, P217
   McPherron AC, 1997, NATURE, V387, P83, DOI 10.1038/387083a0
   Meza-Junco J, 2011, J CLIN ONCOL, V29
   Min L, 2009, ENDOCRINOLOGY, V150, P5606, DOI 10.1210/en.2009-0405
   Montano-Loza AJ, 2016, J CACHEXIA SARCOPENI, V7, P126, DOI 10.1002/jcsm.12039
   Morgentaler A, 2011, EUR UROL, V59, P465, DOI 10.1016/j.eururo.2010.12.027
   Mori H, 2017, J DIABETES INVEST, V8, P377, DOI 10.1111/jdi.12582
   Morley JE, 2003, J GERONTOL A-BIOL, V58, P409
   Murton AJ, 2015, DIABETES, V64, P3160, DOI 10.2337/db15-0021
   Muscariello E, 2016, CLIN INTERV AGING, V11, DOI 10.2147/CIA.S96017
   NAFTOLIN F, 1971, J ENDOCRINOL, V51, P795, DOI 10.1677/joe.0.0510795
   Nakashima K, 2007, BIOSCI BIOTECH BIOCH, V71, P1650, DOI 10.1271/bbb.70057
   Narvaez CJ, 2009, ENDOCRINOLOGY, V150, P651, DOI 10.1210/en.2008-1118
   Nass R, 2009, GROWTH HORM IGF RES, V19, P89, DOI 10.1016/j.ghir.2008.09.002
   Nilsson MI, 2013, FASEB J, V27, P3905, DOI 10.1096/fj.12-224006
   Olesen J, 2010, PFLUG ARCH EUR J PHY, V460, P153, DOI 10.1007/s00424-010-0834-0
   Paddon-Jones D, 2009, CURR OPIN CLIN NUTR, V12, P86, DOI 10.1097/MCO.0b013e32831cef8b
   Patel HJ, 2017, LIFE SCI, V170, P56, DOI 10.1016/j.lfs.2016.11.033
   Pedersen BK, 2012, NAT REV ENDOCRINOL, V8, P457, DOI 10.1038/nrendo.2012.49
   Pedersen Bente Klarlund, 2011, J Exp Biol, V214, P337, DOI 10.1242/jeb.048074
   Pellegrinelli V, 2015, DIABETES, V64, P3121, DOI 10.2337/db14-0796
   Pérez Torres I, 2007, LIFE SCI, V80, P2170, DOI 10.1016/j.lfs.2007.04.006
   Preissner KT, 2012, THROMB HAEMOSTASIS, V108, P415, DOI 10.1160/TH12-08-0540
   Prentice A M, 2001, Obes Rev, V2, P141, DOI 10.1046/j.1467-789x.2001.00031.x
   Rahmouni K, 2005, HYPERTENSION, V45, P9, DOI 10.1161/01.HYP.0000151325.83008.b4
   Ramasamy R, 2005, TRENDS CARDIOVAS MED, V15, P237, DOI 10.1016/j.tcm.2005.08.003
   Raschke S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0073680
   Reid MB, 2001, RESP RES, V2, P269, DOI 10.1186/rr67
   Rieu I, 2006, J PHYSIOL-LONDON, V575, P305, DOI 10.1113/jphysiol.2006.110742
   Roubenoff R, 2000, ANN NY ACAD SCI, V904, P553
   Roustit MM, 2014, J ENDOCRINOL, V223, P143, DOI 10.1530/JOE-14-0181
   Rubio-Ruiz ME, 2013, CURR MED CHEM, V20, P2626, DOI 10.2174/0929867311320210002
   Rubio-Ruiz M.E., 2012, HDB METABOLIC SYNDRO, P169
   Ryall JG, 2008, BIOGERONTOLOGY, V9, P213, DOI 10.1007/s10522-008-9131-0
   Ryan AS, 1999, INT J OBESITY, V23, P126, DOI 10.1038/sj.ijo.0800777
   Sakuma K, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/204164
   Sakuma Kunihiro, 2010, Curr Aging Sci, V3, P90
   Sandri M, 2013, BIOGERONTOLOGY, V14, P303, DOI 10.1007/s10522-013-9432-9
   Sartiani L, 2015, CLIN CASES MINER BON, V12, P135, DOI 10.11138/ccmbm/2015.12.2.135
   Sarwar R, 1996, J PHYSIOL-LONDON, V493, P267, DOI 10.1113/jphysiol.1996.sp021381
   Schaap LA, 2005, CLIN ENDOCRINOL, V63, P152, DOI 10.1111/j.1365-2265.2005.02315.x
   Schaap LA, 2009, J GERONTOL A-BIOL, V64, P1183, DOI 10.1093/gerona/glp097
   Schols AMWJ, 2005, AM J CLIN NUTR, V82, P53, DOI 10.1093/ajcn/82.1.53
   Schubert L, 2010, ARCH BIOCHEM BIOPHYS, V500, P157, DOI 10.1016/j.abb.2010.05.029
   Scott D, 2014, OBESITY, V22, P1568, DOI 10.1002/oby.20734
   Semba RD, 2010, J GERONTOL A-BIOL, V65, P963, DOI 10.1093/gerona/glq074
   Shan TZ, 2014, STEM CELLS, V32, P2893, DOI 10.1002/stem.1788
   Shores MM, 2004, J AM GERIATR SOC, V52, P2077, DOI 10.1111/j.1532-5415.2004.52562.x
   Neto LSS, 2012, BRAZ J PHYS THER, V16, P360
   Sinha-Hikim I, 2006, J CLIN ENDOCR METAB, V91, P3024, DOI 10.1210/jc.2006-0357
   Sipilä S, 2003, J ENDOCRINOL INVEST, V26, P893, DOI 10.1007/BF03345241
   Sirola Joonas, 2005, J Br Menopause Soc, V11, P45, DOI 10.1258/136218005775544561
   Sishi B, 2011, EXP PHYSIOL, V96, P179, DOI 10.1113/expphysiol.2010.054189
   Smith RC, 2013, CURR OPIN SUPPORT PA, V7, P352, DOI 10.1097/SPC.0000000000000013
   Solerte SB, 2008, AM J CARDIOL, V101, p69E, DOI 10.1016/j.amjcard.2008.03.004
   Song DS, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0163222
   Sorensen MB, 2001, OBES RES, V9, P622, DOI 10.1038/oby.2001.81
   Steffl M, 2016, BMC GERIATR, V16, DOI 10.1186/s12877-016-0270-x
   Steinbacher P, 2015, BIOMOLECULES, V5, P356, DOI 10.3390/biom5020356
   Stenholm S, 2008, CURR OPIN CLIN NUTR, V11, P693, DOI 10.1097/MCO.0b013e328312c37d
   Talaei A, 2013, DIABETOL METAB SYNDR, V5, DOI 10.1186/1758-5996-5-8
   Thomas DR, 2010, CLIN GERIATR MED, V26, P331, DOI 10.1016/j.cger.2010.02.012
   Thomson DM, 2005, J APPL PHYSIOL, V98, P557, DOI 10.1152/japplphysiol.00811.2004
   Tiidus PM, 2013, J APPL PHYSIOL, V115, P569, DOI 10.1152/japplphysiol.00629.2013
   Tilg H, 2006, NAT REV IMMUNOL, V6, P772, DOI 10.1038/nri1937
   Traish AM, 2009, J ANDROL, V30, P23, DOI 10.2164/jandrol.108.005751
   Trayhurn Paul, 2011, Archives of Physiology and Biochemistry, V117, P47, DOI 10.3109/13813455.2010.535835
   Umpleby AM, 1996, BAILLIERE CLIN ENDOC, V10, P551, DOI 10.1016/S0950-351X(96)80711-7
   Unger RH, 2005, BIOCHIMIE, V87, P57, DOI 10.1016/j.biochi.2004.11.014
   URBAN RJ, 1995, AM J PHYSIOL-ENDOC M, V269, pE820, DOI 10.1152/ajpendo.1995.269.5.E820
   van Dam PS, 2000, J CLIN ENDOCR METAB, V85, P4706
   van den Beld AW, 2000, J CLIN ENDOCR METAB, V85, P3276, DOI 10.1210/jc.85.9.3276
   van Geel TACM, 2009, EUR J ENDOCRINOL, V160, P681, DOI 10.1530/EJE-08-0702
   Visser M, 2002, J AM GERIATR SOC, V50, P897, DOI 10.1046/j.1532-5415.2002.50217.x
   Visvanathan R, 2010, MATURITAS, V66, P383, DOI 10.1016/j.maturitas.2010.03.020
   Volpi E, 2000, J CLIN ENDOCR METAB, V85, P4481, DOI 10.1210/jc.85.12.4481
   Wagner KR, 2008, ANN NEUROL, V63, P561, DOI 10.1002/ana.21338
   Walsh MC, 2006, OSTEOPOROSIS INT, V17, P61, DOI 10.1007/s00198-005-1900-x
   Wang XN, 2006, ENDOCRINOLOGY, V147, P4160, DOI 10.1210/en.2006-0251
   Wang XW, 2012, AM J PHYSIOL-ENDOC M, V302, pE740, DOI 10.1152/ajpendo.00533.2011
   Waters DL, 2010, CLIN INTERV AGING, V5, P259, DOI 10.2147/CIA.S6920
   Waters DL, 2008, J GERONTOL A-BIOL, V63, P536, DOI 10.1093/gerona/63.5.536
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Weltman A, 2001, Eat Weight Disord, V6, P28
   Wilkes EA, 2009, AM J CLIN NUTR, V90, P1343, DOI 10.3945/ajcn.2009.27543
   Wongwiwatthananukit S, 2013, J ENDOCRINOL INVEST, V36, P558, DOI 10.3275/8817
   Yan QW, 2007, DIABETES, V56, P2533, DOI 10.2337/db07-0007
   Yang RR, 2016, DIABETES RES CLIN PR, V118, P121, DOI 10.1016/j.diabres.2016.06.023
   Yuki A, 2013, SCI REP-UK, V3, DOI 10.1038/srep01818
   Zhang C, 2012, DIABETOLOGIA, V55, P183, DOI 10.1007/s00125-011-2304-4
   Zhang C, 2011, DIABETOLOGIA, V54, P1491, DOI 10.1007/s00125-011-2079-7
   Zoico E, 2004, INT J OBESITY, V28, P234, DOI 10.1038/sj.ijo.0802552
   ZUMOFF B, 1995, J CLIN ENDOCR METAB, V80, P1429, DOI 10.1210/jc.80.4.1429
NR 198
TC 116
Z9 120
U1 0
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB 1
PY 2019
VL 20
IS 3
AR 647
DI 10.3390/ijms20030647
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Chemistry
GA HQ4WR
UT WOS:000462412500191
PM 30717377
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Lozano, I
   Van der Werf, R
   Bietiger, W
   Seyfritz, E
   Peronet, C
   Pinget, M
   Jeandidier, N
   Maillard, E
   Marchioni, E
   Sigrist, S
   Dal, S
AF Lozano, Iona
   Van der Werf, Remmelt
   Bietiger, William
   Seyfritz, Elodie
   Peronet, Claude
   Pinget, Michel
   Jeandidier, Nathalie
   Maillard, Elisa
   Marchioni, Eric
   Sigrist, Severine
   Dal, Stephanie
TI High-fructose and high-fat diet-induced disorders in rats: impact on
   diabetes risk, hepatic and vascular complications
SO NUTRITION & METABOLISM
LA English
DT Article
DE High-fat high-fructose diet; Metabolic syndrome; Type 2 diabetes;
   Oxidative stress; Hepatic complications; Vascular complications;
   Endothelial dysfunction
ID ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   LIVER-DISEASE; METABOLIC SYNDROME; FREE-RADICALS;
   CARDIOVASCULAR-DISEASE; LIPID-METABOLISM; OBESITY; CONSUMPTION
AB Background: As a result of the increased consumption of sugar-rich and fatty-products, and the increase in preference for such products, metabolic disorders are becoming more common at a younger age. Fructose is particularly used in prepared foods and carbonated beverages. We investigated the impact of regular consumption of fructose, in combination or not with fatty food, on the onset of metabolic syndrome and type 2 diabetes (T2D). We evaluated the metabolic, oxidative, and functional effects on the liver and blood vessels, both related to diabetes complications.
   Methods: High-fat diet (HFD), high-fructose beverages (HF) or both (HFHF) were compared to rats fed with normal diet (ND) for 8 months to induce T2D and its metabolic, oxidative, and functional complications. Metabolic control was determined by measuring body weight, fasting blood glucose, C-peptide, HOMA2-IR, leptin, and cholesterol; oxidative parameters were studied by lipid peroxidation and total antioxidant capacity in plasma and the use of ROS labelling on tissue. Histological analysis was performed on the liver and endothelial function was performed in main mesenteric artery using organ-baths.
   Results: After 2 months, HFHF and HFD increased body weight, leptin, HOMA2-IR associated to steatosis, oxidative stress in plasma and tissues, whereas HF had only a transient increase of leptin and c-peptide. Only HFHF induced fasting hyperglycaemia after 6 months and persistent hyperinsulinaemia and fasting hyperglycaemia with complicated steatosis (inflammation and fibrosis) after 8 months. HFHF and HFD induced endothelial dysfunction at 8 months of diet.
   Conclusions: Six months, high fat and high carbohydrate induced T2D with widespread tissues effects. We demonstrated the role of oxidative stress in pathogenesis as well as in complications (hepatic and vascular), reinforcing interest in the use of antioxidants in the prevention and treatment of metabolic diseases, including T2D.
C1 [Lozano, Iona; Van der Werf, Remmelt; Bietiger, William; Seyfritz, Elodie; Peronet, Claude; Maillard, Elisa; Sigrist, Severine; Dal, Stephanie] Univ Strasbourg, UMR DIATHEC, Ctr Europeen Etud Diabet, Federat Med Translat Strasbourg,EA 7294, Bld Rene Leriche, F-67200 Strasbourg, France.
   [Van der Werf, Remmelt; Marchioni, Eric] Fac Pharm, UMR 7178, IPHC LC4, Equipe Chim Analyt Mol BioAct, Illkirch Graffenstaden, France.
   [Pinget, Michel; Jeandidier, Nathalie] HUS, Struct Endocrinol Diabet Nutr & Addictol, Pole NUDE, F-67000 Strasbourg, France.
C3 Universites de Strasbourg Etablissements Associes; Universite de
   Strasbourg; Centre National de la Recherche Scientifique (CNRS); CNRS -
   National Institute of Nuclear and Particle Physics (IN2P3); Universites
   de Strasbourg Etablissements Associes; Universite de Strasbourg; CHU
   Strasbourg
RP Sigrist, S (corresponding author), Univ Strasbourg, UMR DIATHEC, Ctr Europeen Etud Diabet, Federat Med Translat Strasbourg,EA 7294, Bld Rene Leriche, F-67200 Strasbourg, France.
EM s.sigrist@ceed-diabete.org
FU CRA (Conseil Regional d'Alsace); foundation "Vaincre le Diabete";
   company ASDIA (Assistance Service Diabete)
FX We are grateful to the CRA (Conseil Regional d'Alsace), the foundation
   "Vaincre le Diabete", and the company ASDIA (Assistance Service Diabete)
   for funding this project. The authors would also like to express their
   gratitude to Pr Valerie Schini-Kerth (UMR 7175 Centre National de la
   Recherche Scientifique, Universite de Strasbourg, Departement de
   Pharmacologie et Physicochimie, Faculte de Pharmacie, Illkirch, France)
   for lending us the isolated-organ chamber.
CR Adams LA, 2009, AM J GASTROENTEROL, V104, P861, DOI 10.1038/ajg.2009.67
   Arcaro G, 1999, INT J OBESITY, V23, P936, DOI 10.1038/sj.ijo.0801022
   Auberval N, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-130
   Basu S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057873
   Bloch-Damti A, 2005, ANTIOXID REDOX SIGN, V7, P1553, DOI 10.1089/ars.2005.7.1553
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Browning JD, 2004, J CLIN INVEST, V114, P147, DOI 10.1172/JCI200422422
   Bugianesi E, 2010, CURR PHARM DESIGN, V16, P1941, DOI 10.2174/138161210791208875
   Castro MC, 2012, CLIN SCI, V123, P681, DOI 10.1042/CS20110665
   Cleland SJ, 2000, CLIN SCI, V98, P531, DOI 10.1042/CS20000013
   Coate KC, 2010, AM J PHYSIOL-ENDOC M, V299, pE887, DOI 10.1152/ajpendo.00372.2010
   Dabelea D, 2001, J PEDIATR ENDOCR MET, V14, P1085
   Dal S, 2015, EXP BIOL MED
   Dal S, 2015, FUNDAMENTAL CLIN PHA
   Dal-Ros S, 2011, BIOCHEM BIOPH RES CO, V404, P743, DOI 10.1016/j.bbrc.2010.12.060
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   Dekker MJ, 2010, AM J PHYSIOL-ENDOC M, V299, pE685, DOI 10.1152/ajpendo.00283.2010
   Dourmashkin JT, 2005, INT J OBESITY, V29, P1368, DOI 10.1038/sj.ijo.0803017
   Dröge W, 2002, PHYSIOL REV, V82, P47, DOI 10.1152/physrev.00018.2001
   Du L, 2012, MOL ENDOCRINOL, V26, P1773, DOI 10.1210/me.2012-1122
   Elliott SS, 2002, AM J CLIN NUTR, V76, P911, DOI 10.1093/ajcn/76.5.911
   Faeh D, 2005, DIABETES, V54, P1907, DOI 10.2337/diabetes.54.7.1907
   Farese RV, 2005, EXP BIOL MED, V230, P593
   Feinman RD, 2013, NUTR METAB, V10, DOI 10.1186/1743-7075-10-45
   Griendling KK, 2003, CIRCULATION, V108, P2034, DOI 10.1161/01.CIR.0000093661.90582.c4
   Islam MS, 2009, METHOD FIND EXP CLIN, V31, P249, DOI 10.1358/mf.2009.31.4.1362513
   Kim Jung Han, 1998, Journal of Basic and Clinical Physiology and Pharmacology, V9, P325
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Koo HY, 2008, BBA-MOL BASIS DIS, V1782, P341, DOI 10.1016/j.bbadis.2008.02.007
   Lê KA, 2006, AM J CLIN NUTR, V84, P1374, DOI 10.1093/ajcn/84.6.1374
   Lee UE, 2011, BEST PRACT RES CL GA, V25, P195, DOI 10.1016/j.bpg.2011.02.005
   Lenzen S, 2008, DIABETOLOGIA, V51, P216, DOI 10.1007/s00125-007-0886-7
   Liu RH, 2002, INT J OBESITY, V26, P318, DOI 10.1038/sj.ijo.0801924
   López-Soldado I, 2015, DIABETES, V64, P796, DOI 10.2337/db14-0728
   Ludwig DS, 2000, J NUTR, V130, p280S, DOI 10.1093/jn/130.2.280S
   Masayasu I, 1994, LIVER BIOL PATHOBIOL, P443
   Monnier L, 2006, JAMA-J AM MED ASSOC, V295, P1681, DOI 10.1001/jama.295.14.1681
   Nieto N, 2000, J BIOL CHEM, V275, P20136, DOI 10.1074/jbc.M001422200
   Nolan CJ, 2011, LANCET, V378, P169, DOI 10.1016/S0140-6736(11)60614-4
   ORAHILLY S, 1987, DIABETOLOGIA, V30, P394, DOI 10.1007/BF00292540
   Orasanu G, 2009, J AM COLL CARDIOL, V53, pS35, DOI 10.1016/j.jacc.2008.09.055
   Rector RS, 2010, J HEPATOL, V52, P727, DOI 10.1016/j.jhep.2009.11.030
   RHaP D, 1990, ELLENBERG RIFKINS DI
   Ros S, 2011, DIABETOLOGIA, V54, P2639, DOI 10.1007/s00125-011-2238-x
   Ruxton CHS, 2010, CRIT REV FOOD SCI, V50, P1, DOI 10.1080/10408390802248569
   Schwenk RW, 2013, MOL METAB, V2, P337, DOI 10.1016/j.molmet.2013.09.002
   Sena CM, 2013, BBA-MOL BASIS DIS, V1832, P2216, DOI 10.1016/j.bbadis.2013.08.006
   Shapiro A, 2008, AM J PHYSIOL-REG I, V295, pR1370, DOI 10.1152/ajpregu.00195.2008
   Shi Y, 2009, J DIABETES, V1, P151, DOI 10.1111/j.1753-0407.2009.00030.x
   Steinberg HO, 1996, J CLIN INVEST, V97, P2601, DOI 10.1172/JCI118709
   Sutti S, 2014, HEPATOLOGY, V59, P886, DOI 10.1002/hep.26749
   Takaki A, 2013, INT J MOL SCI, V14, P20704, DOI 10.3390/ijms141020704
   Tappy L, 2010, PHYSIOL REV, V90, P23, DOI 10.1152/physrev.00019.2009
   Targher G, 2008, DIABETOLOGIA, V51, P1947, DOI 10.1007/s00125-008-1135-4
   Targher G, 2009, SEMIN THROMB HEMOST, V35, P277, DOI 10.1055/s-0029-1222606
   Tsochatzis E, 2006, AM J GASTROENTEROL, V101, P2629, DOI 10.1111/j.1572-0241.2006.00848.x
   Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
   van Dam RM, 2002, DIABETES CARE, V25, P417, DOI 10.2337/diacare.25.3.417
   Vasdev S, 2004, CLIN BIOCHEM, V37, P1, DOI 10.1016/j.clinbiochem.2003.09.003
   Vehkavaara S, 1999, DIABETES CARE, V22, P2055, DOI 10.2337/diacare.22.12.2055
   Welsh JA, 2010, JAMA-J AM MED ASSOC, V303, P1490, DOI 10.1001/jama.2010.449
   Zhang HR, 2012, BASIC RES CARDIOL, V107, DOI 10.1007/s00395-011-0237-1
NR 62
TC 230
Z9 247
U1 7
U2 140
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD FEB 25
PY 2016
VL 13
AR 15
DI 10.1186/s12986-016-0074-1
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DE9BL
UT WOS:000370930300001
PM 26918024
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Tapia, E
   Cristóbal, M
   García-Arroyo, FE
   Soto, V
   Monroy-Sánchez, F
   Pacheco, U
   Lanaspa, MA
   Roncal-Jiménez, CA
   Cruz-Robles, D
   Ishimoto, T
   Madero, M
   Johnson, RJ
   Sánchez-Lozada, LG
AF Tapia, Edilia
   Cristobal, Magdalena
   Garcia-Arroyo, Fernando E.
   Soto, Virgilia
   Monroy-Sanchez, Fabiola
   Pacheco, Ursino
   Lanaspa, Miguel A.
   Roncal-Jimenez, Carlos A.
   Cruz-Robles, David
   Ishimoto, Takuji
   Madero, Magdalena
   Johnson, Richard J.
   Sanchez-Lozada, Laura-Gabriela
TI Synergistic effect of uricase blockade plus physiological amounts of
   fructose-glucose on glomerular hypertension and oxidative stress in rats
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE uric acid; insulin resistance; glomerular hypertension; liver steatosis
ID SWEETENED BEVERAGE CONSUMPTION; INDUCED METABOLIC SYNDROME; SERUM URATE
   LEVELS; BLOOD-PRESSURE; INSULIN SENSITIVITY; SPRAGUE-DAWLEY;
   POTENTIAL-ROLE; BREEDER RATS; FATTY LIVER; ACID
AB Tapia E, Cristobal M, Garcia-Arroyo FE, Soto V, Monroy-Sanchez F, Pacheco U, Lanaspa MA, Roncal-Jimenez CA, Cruz-Robles D, Ishimoto T, Madero M, Johnson RJ, Sanchez-Lozada LG. Synergistic effect of uricase blockade plus physiological amounts of fructose-glucose on glomerular hypertension and oxidative stress in rats. Am J Physiol Renal Physiol 304: F727-F736, 2013. First published January 9, 2012; doi:10.1152/ajprenal.00485.2012.-Fructose in sweetened beverages (SB) increases the risk for metabolic and cardiorenal disorders, and these effects are in part mediated by a secondary increment in uric acid (UA). Rodents have an active uricase, thus requiring large doses of fructose to increase plasma UA and to induce metabolic syndrome and renal hemodynamic changes. We therefore hypothesized that the effects of fructose in rats might be enhanced in the setting of uricase inhibition. Four groups of male Sprague-Dawley rats (n = 7/group) were studied during 8 wk: water + vehicle (V), water + oxonic acid (OA; 750 mg/k BW), sweetened beverage (SB; 11% fructose-glucose combination) + V, and SB + OA. Systemic blood pressure, plasma UA, triglycerides (TG), glucose and insulin, glomerular hemodynamics, renal structural damage, renal cortex and liver UA, TG, markers of oxidative stress, mitDNA, fructokinase, and fatty liver synthase protein expressions were evaluated at the end of the experiment. Chronic hyperuricemia and SB induced features of the metabolic syndrome, including hypertension, hyperuricemia, hyperglycemia, and systemic and hepatic TG accumulation. OA alone also induced glomerular hypertension, and SB alone induced insulin resistance. SB + OA induced a combined phenotype including metabolic and renal alterations induced by SB or OA alone and in addition also acted synergistically on systemic and glomerular pressure, plasma glucose, hepatic TG, and oxidative stress. These findings explain why high concentrations of fructose are required to induce greater metabolic changes and renal disease in rats whereas humans, who lack uricase, appear to be much more sensitive to the effects of fructose.
C1 [Tapia, Edilia; Cristobal, Magdalena; Garcia-Arroyo, Fernando E.; Monroy-Sanchez, Fabiola; Pacheco, Ursino; Sanchez-Lozada, Laura-Gabriela] Inst Nacl Cardiol Ignacio Chavez, Lab Renal Physiopathol, Mexico City, DF, Mexico.
   [Tapia, Edilia; Cristobal, Magdalena; Garcia-Arroyo, Fernando E.; Monroy-Sanchez, Fabiola; Pacheco, Ursino; Madero, Magdalena; Sanchez-Lozada, Laura-Gabriela] Inst Nacl Cardiol Ignacio Chavez, Dept Nephrol, Mexico City, DF, Mexico.
   [Soto, Virgilia] Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Mexico City, DF, Mexico.
   [Lanaspa, Miguel A.; Roncal-Jimenez, Carlos A.; Ishimoto, Takuji; Johnson, Richard J.] Univ Colorado, Div Renal Dis & Hypertens, Denver, CO 80202 USA.
   [Cruz-Robles, David] Inst Nacl Cardiol Ignacio Chavez, Dept Mol Biol, Mexico City, DF, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico; National Institute of Cardiology - Mexico;
   University of Colorado System; University of Colorado Denver; National
   Institute of Cardiology - Mexico
RP Sánchez-Lozada, LG (corresponding author), INC Ignacio Chavez Mexico City, Lab Renal Physiopathol, Juan Badiano 1, Mexico City 14080, DF, Mexico.
EM lgsanchezlozada@gmail.com
RI Sanchez-Lozada, Laura/AAS-2104-2021; Lanaspa, Miguel/AAO-4971-2020;
   Cruz-Robles, David/C-7278-2015; Ishimoto, Takuji/M-4873-2014
OI Tapia, Edilia/0000-0001-7955-816X; Cruz-Robles,
   David/0000-0003-4234-9561; Ishimoto, Takuji/0000-0002-9861-5331;
   Sanchez-Lozada, Laura-Gabriela/0000-0003-0348-9617; Garcia Arroyo,
   Fernando Enrique/0000-0003-1545-9765
FU National Heart, Lung, and Blood Institute [HL-068607-10]; National
   Council of Science and Technology (CONACyT) Mexico [133232, 167949]
FX Funding was supported in part by National Heart, Lung, and Blood
   Institute Grant HL-068607-10 and National Council of Science and
   Technology (CONACyT) Mexico Grants 133232 and No. 167949.
CR Abuja PM, 1999, FEBS LETT, V446, P305, DOI 10.1016/S0014-5793(99)00231-8
   Aeberli I, 2011, AM J CLIN NUTR, V94, P479, DOI 10.3945/ajcn.111.013540
   Aguirre V, 2002, J BIOL CHEM, V277, P1531, DOI 10.1074/jbc.M101521200
   Assy N, 2008, CAN J GASTROENTEROL, V22, P811, DOI 10.1155/2008/810961
   Barone S, 2009, J BIOL CHEM, V284, P5056, DOI 10.1074/jbc.M808128200
   BAYLIS C, 1976, AM J PHYSIOL, V230, P1148, DOI 10.1152/ajplegacy.1976.230.4.1148
   Bomback AS, 2010, KIDNEY INT, V77, P609, DOI 10.1038/ki.2009.500
   Brown IJ, 2011, HYPERTENSION, V57, P695, DOI 10.1161/HYPERTENSIONAHA.110.165456
   Cacho J, 2008, AM J PHYSIOL-ENDOC M, V295, pE1269, DOI 10.1152/ajpendo.90207.2008
   Chen LW, 2010, CIRCULATION, V121, P2398, DOI 10.1161/CIRCULATIONAHA.109.911164
   Cirillo P, 2009, J AM SOC NEPHROL, V20, P545, DOI 10.1681/ASN.2008060576
   Cohen L, 2012, J GEN INTERN MED, V27, P1127, DOI 10.1007/s11606-012-2069-6
   Cosenzi A, 1999, J HYPERTENS, V17, P1843, DOI 10.1097/00004872-199917121-00010
   Cosenzi A, 1999, J HYPERTENS, V17, P965, DOI 10.1097/00004872-199917070-00013
   DAVIDSON WD, 1963, J LAB CLIN MED, V62, P351
   de Koning L, 2012, CIRCULATION, V125, P1735, DOI 10.1161/CIRCULATIONAHA.111.067017
   Feng MJ, 2008, AM J HYPERTENS, V21, P1288, DOI 10.1038/ajh.2008.301
   Gérard-Monnier D, 1998, CHEM RES TOXICOL, V11, P1176, DOI 10.1021/tx9701790
   Gersch MS, 2007, AM J PHYSIOL-RENAL, V293, pF1256, DOI 10.1152/ajprenal.00181.2007
   HALLFRISCH J, 1990, FASEB J, V4, P2652, DOI 10.1096/fasebj.4.9.2189777
   Hu FB, 2010, PHYSIOL BEHAV, V100, P47, DOI 10.1016/j.physbeh.2010.01.036
   Ishimoto T, 2012, P NATL ACAD SCI USA, V109, P4320, DOI 10.1073/pnas.1119908109
   Jin R, 2012, J CLIN ENDOCR METAB, V97, pE1088, DOI 10.1210/jc.2012-1370
   Johnson RK, 2009, CIRCULATION, V120, P1011, DOI 10.1161/CIRCULATIONAHA.109.192627
   Johnson RJ, 2007, AM J CLIN NUTR, V86, P899
   Johnson RJ, 2010, EVOL ANTHROPOL, V19, P250, DOI 10.1002/evan.20266
   Johnson RJ, 2009, ENDOCR REV, V30, P96, DOI 10.1210/er.2008-0033
   Kanellis J, 2003, HYPERTENSION, V41, P1287, DOI 10.1161/01.HYP.0000072820.07472.3B
   Kang DH, 2005, J AM SOC NEPHROL, V16, P3553, DOI 10.1681/ASN.2005050572
   Kang DH, 2002, J AM SOC NEPHROL, V13, P2888, DOI 10.1097/01.ASN.0000034910.58454.FD
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   Khosla UM, 2005, KIDNEY INT, V67, P1739, DOI 10.1111/j.1523-1755.2005.00273.x
   Lanaspa MA, 2012, J BIOL CHEM, V287, P40732, DOI 10.1074/jbc.M112.399899
   Lisi S, 2011, DIABETES, V60, P2496, DOI 10.2337/db10-1536
   Ludwig DS, 2002, JAMA-J AM MED ASSOC, V287, P2414, DOI 10.1001/jama.287.18.2414
   Luippold G, 2004, NEPHROL DIAL TRANSPL, V19, P342, DOI 10.1093/ndt/gfg584
   Malik VS, 2010, DIABETES CARE, V33, P2477, DOI 10.2337/dc10-1079
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mazzali M, 2001, HYPERTENSION, V38, P1101, DOI 10.1161/hy1101.092839
   Mazzali M, 2002, AM J PHYSIOL-RENAL, V282, pF991, DOI 10.1152/ajprenal.00283.2001
   Nakagawa T, 2003, AM J NEPHROL, V23, P2, DOI 10.1159/000066303
   Nicklas JA, 2004, ENVIRON MOL MUTAGEN, V44, P313, DOI 10.1002/em.20050
   Okva K, 2006, SCAND J LAB ANIM SCI, V33, P243
   Onuma S, 2004, METABOLISM, V53, P1305, DOI 10.1016/j.metabol.2004.05.005
   Pagliassotti MJ, 1997, AM J PHYSIOL-REG I, V272, pR526, DOI 10.1152/ajpregu.1997.272.2.R526
   REZNICK AZ, 1994, METHOD ENZYMOL, V233, P357
   Roncal-Jimenez CA, 2011, METABOLISM, V60, P1259, DOI 10.1016/j.metabol.2011.01.008
   Sánchez-Lozada LG, 2008, AM J PHYSIOL-RENAL, V295, pF1134, DOI 10.1152/ajprenal.00104.2008
   Sánchez-Lozada LG, 2008, AM J PHYSIOL-RENAL, V294, pF710, DOI 10.1152/ajprenal.00454.2007
   Sánchez-Lozada LG, 2007, AM J PHYSIOL-RENAL, V292, pF1238, DOI 10.1152/ajprenal.00164.2006
   Sanchez-Lozada LG, 2007, AM J PHYSIOL-RENAL, V292, pF423, DOI 10.1152/ajprenal.00124.2006
   Sánchez-Lozada LG, 2002, AM J PHYSIOL-RENAL, V283, pF1105, DOI 10.1152/ajprenal.00170.2002
   Sánchez-Lozada LG, 2005, KIDNEY INT, V67, P237, DOI 10.1111/j.1523-1755.2005.00074.x
   Sánchez-Lozada LG, 2003, KIDNEY INT, V64, pS9, DOI 10.1046/j.1523-1755.64.s86.3.x
   Schwarz JM, 1995, J CLIN INVEST, V96, P2735, DOI 10.1172/JCI118342
   Singh AK, 2008, KIDNEY INT, V74, P438, DOI 10.1038/ki.2008.184
   Singh R, 2009, AM J PHYSIOL-GASTR L, V297, pG907, DOI 10.1152/ajpgi.00151.2009
   STAVRIC B, 1976, EXPERIENTIA, V32, P373, DOI 10.1007/BF01940847
   Tapia E, 2003, KIDNEY INT, V63, P994, DOI 10.1046/j.1523-1755.2003.00811.x
   Ventura EE, 2011, OBESITY, V19, P868, DOI 10.1038/oby.2010.255
   VIETS JW, 1978, ANAL BIOCHEM, V88, P513, DOI 10.1016/0003-2697(78)90451-7
   Vos Miriam B, 2008, Medscape J Med, V10, P160
   VUREK GG, 1966, ANAL BIOCHEM, V16, P409, DOI 10.1016/0003-2697(66)90222-3
   Wei YR, 2007, J NUTR BIOCHEM, V18, P1, DOI 10.1016/j.jnutbio.2006.03.013
   WEXLER BC, 1982, P SOC EXP BIOL MED, V170, P476
   WEXLER BC, 1977, METABOLISM, V26, P1309, DOI 10.1016/0026-0495(77)90027-0
   Wilcox CS, 2003, ACTA PHYSIOL SCAND, V179, P217, DOI 10.1046/j.0001-6772.2003.01205.x
   YONETANI Y, 1987, JPN J PHARMACOL, V45, P37, DOI 10.1254/jjp.45.37
   Yu MA, 2010, J HYPERTENS, V28, P1234, DOI 10.1097/HJH.0b013e328337da1d
   Zharikov S, 2008, AM J PHYSIOL-CELL PH, V295, pC1183, DOI 10.1152/ajpcell.00075.2008
NR 70
TC 61
Z9 65
U1 1
U2 26
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD MAR
PY 2013
VL 304
IS 6
BP F727
EP F736
DI 10.1152/ajprenal.00485.2012
PG 10
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA 107EG
UT WOS:000316197000011
PM 23303409
OA Green Published
DA 2025-06-11
ER

PT J
AU Alroy, S
   Preis, M
   Barzilai, M
   Cassel, A
   Lavie, L
   Halon, DA
   Amir, O
   Lewis, BS
   Flugelman, MY
AF Alroy, Sharon
   Preis, Meir
   Barzilai, Menashe
   Cassel, Aliza
   Lavie, Lena
   Halon, David A.
   Amir, Ofer
   Lewis, Basil S.
   Flugelman, Moshe Y.
TI Endothelial cell dysfunction in women with cardiac syndrome X and
   MTHFR C677T mutation
SO ISRAEL MEDICAL ASSOCIATION JOURNAL
LA English
DT Article
DE syndrome X; MTHFR; homocysteine
ID NORMAL CORONARY-ARTERIES; METHYLENETETRAHYDROFOLATE REDUCTASE;
   ANGINA-PECTORIS; FOLIC-ACID; VASCULAR-DISEASE; COMMON MUTATION; RISK
   FACTOR; CHEST PAIN; HOMOCYSTEINE; HYPERHOMOCYSTEINEMIA
AB Background: The etiology of chest pain with normal epicardial coronary arteries (cardiac syndrome X) seems to be related to endothelial cell dysfunction. Multiple factors are implicated in the pathophysiology, including elevated levels of homocysteine in the blood. Mutations in the MTHFR gene are associated with elevated levels of homocysteine.
   Objectives: To test whether abnormal homocysteine metabolism is associated with syndrome X.
   Methods: Forty-two women with chest pain, positive stress test and normal coronary arteries (syndrome X) and 100 asymptomatic women (controls) were studied for the C677T mutation. Vitamin 1312, folic acid, and plasma levels of homocysteine were also measured. Endothelial cell function was studied in 10 patients with syndrome X and homozygosity for C677T mutation, and in 10 matched healthy controls. Folic acid (5 mg daily) was prescribed to syndrome X patients after initial measurements of ECF. Following 13 weeks of treatment, ECF and blood tests were repeated and compared to baseline measurements.
   Results: Homozygosity for C677T mutation was doubled in syndrome X vs. control (33%, 14/42 vs. 16%, 16/100, P < 0.02), and homocysteine levels were increased (9.16 +/- 2.4 vs. 8.06 +/- 2.6 mu mol/L, P= 0.02). In the 10 homozygous patients, homocysteine levels decreased significantly after treatment with 5 mg/day folic acid (10 +/- 3.3 vs. 5.4 +/- 1.1 mu mol/L, P= 0.004). Abnormal baseline ECF improved after treatment with folic acid: flow-mediated dilatation was greater (11.3 +/- 7.9% vs. 0.7 +/- 4.5%, P < 0.002), as was nitroglycerin mediated dilatation (15.2 +/- 9.0% vs. 5.6 +/- 6.4%, P < 0.003). Frequency of chest pain episodes was significantly reduced after 13 weeks of folic acid treatment.
   Conclusion: Our findings establish the association between the C677T mutation, endothelial cell dysfunction and cardiac syndrome X, and provide a novel and simple therapy for a subset of patients with syndrome X and homozygosity for the C677T mutation.
C1 Lady Davies Carmel Med Ctr, Dept Cardiovasc Med, IL-34632 Haifa, Israel.
   Lady Davies Carmel Med Ctr, Dept Radiol, IL-34632 Haifa, Israel.
   Lady Davies Carmel Med Ctr, Dept Mol Hematol, IL-34632 Haifa, Israel.
   Technion Israel Inst Technol, Rappaport Fac Med, Dept Cell Biol, Haifa, Israel.
C3 Clalit Health Services; Carmel Medical Center; Clalit Health Services;
   Carmel Medical Center; Clalit Health Services; Carmel Medical Center;
   Technion Israel Institute of Technology; Rappaport Faculty of Medicine
RP Flugelman, MY (corresponding author), Lady Davies Carmel Med Ctr, Dept Cardiovasc Med, IL-34632 Haifa, Israel.
EM preis_m@netvision.net.il; myf@tx.technion.ac.il
RI Lavandero, Sergio/B-6001-2013; Preis, Meir/ABH-7606-2020
OI Halon, David/0000-0003-1865-7919
CR Amir O, 2004, AM J CARDIOL, V93, P947, DOI 10.1016/j.amjcard.2003.12.032
   Arroyo-Espliguero R, 2003, EUR HEART J, V24, P2006, DOI 10.1016/j.ehj.2003.09.029
   Bellamy MF, 1998, CIRCULATION, V98, P1848, DOI 10.1161/01.CIR.98.18.1848
   Brattström L, 1998, CIRCULATION, V98, P2520, DOI 10.1161/01.CIR.98.23.2520
   Brattström L, 1998, BMJ-BRIT MED J, V316, P894, DOI 10.1136/bmj.316.7135.894
   CANNON RO, 1988, AM J CARDIOL, V61, P1338, DOI 10.1016/0002-9149(88)91180-0
   Chambers JC, 1999, ARTERIOSCL THROM VAS, V19, P2922, DOI 10.1161/01.ATV.19.12.2922
   Crea F, 2004, HEART, V90, P457, DOI 10.1136/hrt.2003.020594
   EGASHIRA K, 1993, NEW ENGL J MED, V328, P1659, DOI 10.1056/NEJM199306103282302
   FLUGELMAN MY, 1991, INT J CARDIOL, V33, P401, DOI 10.1016/0167-5273(91)90069-2
   FROSST P, 1995, NAT GENET, V10, P111, DOI 10.1038/ng0595-111
   Jacques PF, 1996, CIRCULATION, V93, P7, DOI 10.1161/01.CIR.93.1.7
   KASKI JC, 1995, J AM COLL CARDIOL, V25, P807, DOI 10.1016/0735-1097(94)00507-M
   Kupferminc MJ, 1999, NEW ENGL J MED, V340, P9, DOI 10.1056/NEJM199901073400102
   Lavie L, 2001, CHEST, V120, P900, DOI 10.1378/chest.120.3.900
   Lekakis JP, 1998, J AM COLL CARDIOL, V31, P541, DOI 10.1016/S0735-1097(97)00542-1
   Lentz SR, 1997, LIFE SCI, V61, P1205, DOI 10.1016/S0024-3205(97)00392-5
   Malinow MR, 1999, CIRCULATION, V99, P178, DOI 10.1161/01.CIR.99.1.178
   Masci PG, 2005, AM J CARDIOL, V95, P1478, DOI 10.1016/j.amjcard.2005.02.018
   Seligsohn U, 1997, THROMB HAEMOSTASIS, V78, P297
   SORENSEN KE, 1995, BRIT HEART J, V74, P247
   Stroes ESG, 2000, CIRC RES, V86, P1129
   van Asselt KM, 2006, CIRCULATION, V113, P1136, DOI 10.1161/CIRCULATIONAHA.105.563197
   Wilmink HW, 2000, ARTERIOSCL THROM VAS, V20, P185, DOI 10.1161/01.ATV.20.1.185
   Woo KS, 1997, CIRCULATION, V96, P2542, DOI 10.1161/01.CIR.96.8.2542
NR 25
TC 13
Z9 14
U1 0
U2 3
PU ISRAEL MEDICAL ASSOC JOURNAL
PI RAMAT GAN
PA 2 TWIN TOWERS, 11TH FL, 35 JABOTINSKY ST, PO BOX 3604, RAMAT GAN 52136,
   ISRAEL
SN 1565-1088
J9 ISR MED ASSOC J
JI Isr. Med. Assoc. J.
PD APR
PY 2007
VL 9
IS 4
BP 321
EP 325
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 162YH
UT WOS:000246124900022
PM 17491230
DA 2025-06-11
ER

PT J
AU Mahdavi, A
   Mohammadi, H
   Foshati, S
   Shokri-Mashhadi, N
   Clark, CCT
   Moafi, A
   Rouhani, MH
AF Mahdavi, Atena
   Mohammadi, Hamed
   Foshati, Sahar
   Shokri-Mashhadi, Nafiseh
   Clark, Cain C. T.
   Moafi, Alireza
   Rouhani, Mohammad Hossein
TI Effects of the dietary approach to stop hypertension (DASH) diet on
   blood pressure, blood glucose, and lipid profile in adolescents with
   hemophilia: A randomized clinical trial
SO FOOD SCIENCE & NUTRITION
LA English
DT Article
DE adolescents; blood glucose; blood pressure; dietary approach to stop
   hypertension; hemophilia; lipid profile
ID CHILDHOOD METABOLIC SYNDROME; CARDIOVASCULAR RISK; METAANALYSIS;
   COMORBIDITIES; CHILDREN; OBESITY; STRESS; SODIUM; FOLLOW
AB Children with hemophilia are an enhanced risk of modifiable cardiovascular and metabolic abnormalities. There is currently no nutritional guideline to prevent or manage cardiometabolic risk factors in these patients. Therefore, the present study sought to investigate the effect of the Dietary Approaches to Stop Hypertension (DASH) diet on cardiovascular and metabolic risk factors among children with hemophilia. In this parallel randomized clinical trial, 40 children (all male) with hemophilia were randomly allocated to the DASH group (n = 20) or control group (n = 20) for 10 weeks. The intervention group received the DASH diet (50%-55% of energy from carbohydrate, 27%-30% of energy from fat and 16%-18% energy from protein), and the control group received nutritional recommendations based on healthy eating practices. Systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood sugar (FBS), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were measured at the beginning and end of the study. Serum vitamin C was measured as a biomarker of compliance with the DASH diet. Study was registered at IRCT.ir (IRCT20130903014551N6). A significant increase in serum vitamin C in the DASH diet group was observed compared to the control group (p = .001), indicating good compliance with the DASH diet. There was a significant reduction in SBP (-0.48 mmHg), DBP (-0.48 mmHg), FBS (-5.86 mg/dl), TC (-16.07 mg/dl), TG (-17.21 mg/dl), and LDL-C (-9.79 mg/dl), and a significant increase in HDL-C (3.39 mg/dl), in the DASH diet group compared with the control group. Adherence to the DASH diet in children with hemophilia yielded beneficial effects in blood pressure, lipid profiles, and FBS.
C1 [Mahdavi, Atena; Mohammadi, Hamed; Foshati, Sahar; Shokri-Mashhadi, Nafiseh; Rouhani, Mohammad Hossein] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Food Secur Res Ctr, Esfahan, Iran.
   [Mahdavi, Atena; Rouhani, Mohammad Hossein] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
   [Mohammadi, Hamed; Foshati, Sahar; Shokri-Mashhadi, Nafiseh] Isfahan Univ Med Sci, Dept Clin Nutr, Sch Nutr & Food Sci, Esfahan, Iran.
   [Clark, Cain C. T.] Coventry Univ, Ctr Intelligent Healthcare, Coventry, W Midlands, England.
   [Moafi, Alireza] Isfahan Univ Med Sci, Pediat Hematol & Oncol, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Coventry University;
   Isfahan University of Medical Sciences
RP Rouhani, MH (corresponding author), Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
EM sm_rouhani@nutr.mui.ac.ir
RI Rouhani, Mohammad/H-6937-2019; Foshati, Sahar/AAR-2447-2020; Mohammadi,
   Hamed/Q-3166-2019; Clark, Cain/I-4480-2019; shokri-Mashhadi,
   nafiseh/AAU-5129-2020
OI Foshati, Sahar/0000-0002-2669-670X; Rouhani, Mohammad
   Hossein/0000-0003-2451-0083; Clark, Dr. Cain/0000-0002-6610-4617
CR Akhlaghi M, 2020, NUTR RES REV, V33, P1, DOI 10.1017/S0954422419000155
   Akita S, 2003, HYPERTENSION, V42, P8, DOI 10.1161/01.HYP.0000074668.08704.6E
   Al-Solaiman Y, 2009, J HUM HYPERTENS, V23, P826, DOI 10.1038/jhh.2009.32
   Alperstein W, 2018, J PEDIAT HEMATOL ONC, V40, P196, DOI 10.1097/MPH.0000000000001036
   Ard JD, 2004, DIABETES CARE, V27, P340, DOI 10.2337/diacare.27.2.340
   Azadbakht L, 2005, DIABETES CARE, V28, P2823, DOI 10.2337/diacare.28.12.2823
   Bazzano LA, 2013, CURR HYPERTENS REP, V15, P694, DOI 10.1007/s11906-013-0390-z
   Bricarello LP, 2018, CLIN NUTR ESPEN, V28, P1, DOI 10.1016/j.clnesp.2018.09.003
   Chinnappa G. D., 2020, INT J CONT PEDIAT, V7, P1232, DOI [10.18203/2349-3291.ijcp20202026, DOI 10.18203/2349-3291.IJCP20202026]
   Couch SC, 2008, J PEDIATR-US, V152, P494, DOI 10.1016/j.jpeds.2007.09.022
   Czepa D, 2014, HAMOSTASEOLOGIE, V34, pS43, DOI 10.5482/HAMO-14-02-0012
   Heshmati J, 2019, J DIET SUPPL, V16, P357, DOI 10.1080/19390211.2018.1440685
   Lewington S, 2002, LANCET, V360, P1903, DOI 10.1016/S0140-6736(02)11911-8
   Lin PH, 2012, J NUTR METAB, V2012, DOI 10.1155/2012/472396
   Lind MV, 2019, AM J CLIN NUTR, V109, P29, DOI 10.1093/ajcn/nqy234
   Malhotra JD, 2008, P NATL ACAD SCI USA, V105, P18525, DOI 10.1073/pnas.0809677105
   Mente A, 2014, NEW ENGL J MED, V371, P601, DOI 10.1056/NEJMoa1311989
   Miller Edgar R 3rd, 2006, Curr Atheroscler Rep, V8, P460, DOI 10.1007/s11883-006-0020-1
   Neter JE, 2003, HYPERTENSION, V42, P878, DOI 10.1161/01.HYP.0000094221.86888.AE
   Özdemir ZC, 2020, THROMB RES, V189, P102, DOI 10.1016/j.thromres.2020.03.004
   Papathanasopoulos A, 2010, GASTROENTEROLOGY, V138, P65, DOI 10.1053/j.gastro.2009.11.045
   Philipp C, 2010, HEMATOL-AM SOC HEMAT, P191, DOI 10.1182/asheducation-2010.1.191
   Pocoski J, 2014, HAEMOPHILIA, V20, P472, DOI 10.1111/hae.12339
   Radulian G, 2009, NUTR J, V8, DOI 10.1186/1475-2891-8-5
   Rolls BJ, 2005, J AM DIET ASSOC, V105, pS98, DOI 10.1016/j.jada.2005.02.033
   Saneei P, 2014, NUTR METAB CARDIOVAS, V24, P1253, DOI 10.1016/j.numecd.2014.06.008
   Saneei P, 2014, ANN NUTR METAB, V64, P20, DOI 10.1159/000358341
   Saneei P, 2013, BRIT J NUTR, V110, P2250, DOI 10.1017/S0007114513001724
   Schwingshackl L, 2019, CRIT REV FOOD SCI, V59, P2674, DOI 10.1080/10408398.2018.1463967
   Shirani F, 2013, NUTRITION, V29, P939, DOI 10.1016/j.nut.2012.12.021
   Siervo M, 2015, BRIT J NUTR, V113, P1, DOI 10.1017/S0007114514003341
   Simental-Mendía LE, 2016, PHARMACOL RES, V111, P272, DOI 10.1016/j.phrs.2016.06.019
   Singleton T, 2010, J EMERG MED, V39, P158, DOI 10.1016/j.jemermed.2007.12.024
   Soltani S, 2018, CLIN NUTR, V37, P542, DOI 10.1016/j.clnu.2017.02.018
   Song S, 2016, CLIN NUTR, V35, P885, DOI 10.1016/j.clnu.2015.06.002
   Sousos N, 2016, THROMB RES, V140, P14, DOI 10.1016/j.thromres.2016.02.001
   Stoffman J, 2019, HEMATOLOGY, V24, P39, DOI 10.1080/10245332.2018.1505225
   Taylor EN, 2010, CLIN J AM SOC NEPHRO, V5, P2315, DOI 10.2215/CJN.04420510
   Wong TE, 2011, AM J PREV MED, V41, pS369, DOI 10.1016/j.amepre.2011.09.008
   Xi WN, 2018, CONT CLIN TRIAL COMM, V11, P20, DOI 10.1016/j.conctc.2018.05.008
   Yildiz M, 2019, J CLIN RES PEDIATR E, V11, P173, DOI 10.4274/jcrpe.galenos.2018.2018.0292
   Zimmerman B, 2013, PEDIATR REV, V34, P289, DOI 10.1542/pir.34-7-289
NR 42
TC 10
Z9 10
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2048-7177
J9 FOOD SCI NUTR
JI Food Sci. Nutr.
PD JAN
PY 2021
VL 9
IS 1
BP 145
EP 153
DI 10.1002/fsn3.1972
EA OCT 2020
PG 9
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA PS2AE
UT WOS:000585927200001
PM 33473278
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Vranian, MN
   Keenan, T
   Blaha, MJ
   Silverman, MG
   Michos, ED
   Minder, CM
   Blumenthal, RS
   Nasir, K
   Meneghelo, RS
   Santos, RD
AF Vranian, Michael N.
   Keenan, Tanya
   Blaha, Michael J.
   Silverman, Michael G.
   Michos, Erin D.
   Minder, C. Michael
   Blumenthal, Roger S.
   Nasir, Khurram
   Meneghelo, Romeu S.
   Santos, Raul D.
TI Impact of Fitness Versus Obesity on Routinely Measured Cardiometabolic
   Risk in Young, Healthy Adults
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID CARDIOVASCULAR-DISEASE MORTALITY; CARDIORESPIRATORY FITNESS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; AEROBIC FITNESS; FATNESS; MEN;
   PREDICTORS; ASSOCIATIONS
AB Obesity demonstrates a direct relation with cardiovascular risk and all-cause mortality, while cardiorespiratory fitness demonstrates an inverse relation. In clinical practice, several cardiometabolic (CM) risk factors are commonly measured to gauge cardiovascular risk, but the interaction between fitness and obesity with regard to CM risk has not been fully explored. In this study, 2,634 Brazilian adults referred for employer-sponsored heath exams were assessed. Obesity was defined as body mass index >30 kg/m(2) or waist circumference >102 cm in men or >88 cm in women when body mass index was 25 to 30 kg/m(2). Fitness was quantified by stage achieved on an Ellestad treadmill stress test, with those completing stage 4 considered fit. Hepatic steatosis was determined by ultrasound. CM risk factors were compared after stratifying patients into 4 groups: fit and normal weight, fit and obese, unfit and normal weight, and unfit and obese. Approximately 22% of patients were obese; 12% were unfit. Fitness and obesity were moderately correlated (rho = 0.38 to 0.50). The sample included 6.5% unfit and normal-weight subjects and 16% fit and obese subjects. In overweight and obese patients, fitness was negatively associated with CM risk (p < 0.01 for all values). In fit patients, increasing body mass index was positively associated with CM risk (p < 0.01 for all values). In instances of discordance between fitness and obesity, obesity was the stronger determinant of CM risk. In conclusion, fitness and obesity are independently associated with CM risk. The effects of fitness and obesity are additive, but obesity is more strongly associated with CM risk when fitness and obesity are discordant. These findings underscore the need for weight loss in obese patients and suggest an unmeasured benefit of fitness. (C) 2013 Elsevier Inc. All rights reserved. (Am J Cardiol 2013;111:991-995)
C1 [Vranian, Michael N.; Blaha, Michael J.; Silverman, Michael G.; Michos, Erin D.; Minder, C. Michael; Blumenthal, Roger S.; Nasir, Khurram] Johns Hopkins Ciccarone Ctr Prevent Heart Dis, Baltimore, MD USA.
   [Keenan, Tanya] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA.
   [Nasir, Khurram] Baptist Hlth South Florida, Miami, FL USA.
   [Meneghelo, Romeu S.; Santos, Raul D.] Hosp Israelita Albert Einstein, Prevent Med Ctr, Sao Paulo, Brazil.
   [Santos, Raul D.] Univ Sao Paulo, Med Sch Hosp, Inst Heart, Lipid Clin, Sao Paulo, Brazil.
C3 Johns Hopkins University; Johns Hopkins Medicine; University of
   Pennsylvania; Hospital Israelita Albert Einstein; Universidade de Sao
   Paulo
RP Santos, RD (corresponding author), Hosp Israelita Albert Einstein, Prevent Med Ctr, Sao Paulo, Brazil.
EM raul.santos@incor.usp.br
RI Nasir, Khurram/A-2317-2008; Santos, Raul/A-1170-2010; Blumenthal,
   Roger/H-3223-2018
OI Michos, Erin/0000-0002-5547-5084; Keenan, Tanya/0000-0001-5300-9998
CR [Anonymous], RADIOL RES PRACT
   [Anonymous], ACSMS MET CALC HDB
   Bellentani S, 2000, ANN INTERN MED, V132, P112, DOI 10.7326/0003-4819-132-2-200001180-00004
   Borodulin K, 2005, EUR J CARDIOV PREV R, V12, P126, DOI 10.1097/00149831-200504000-00006
   Christou DD, 2005, CIRCULATION, V111, P1904, DOI 10.1161/01.CIR.0000161818.28974.1A
   Church TS, 2005, ARCH INTERN MED, V165, P2114, DOI 10.1001/archinte.165.18.2114
   Dobiásová M, 2011, J LIPID RES, V52, P566, DOI 10.1194/jlr.P011668
   Farrell SW, 1998, MED SCI SPORT EXER, V30, P899, DOI 10.1097/00005768-199806000-00019
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Gulati M, 2005, NEW ENGL J MED, V353, P468, DOI 10.1056/NEJMoa044154
   Hamer M, 2009, AM J CLIN NUTR, V89, P85, DOI 10.3945/ajcn.2008.26779
   International Diabetes Federation, 2006, IDF CONS WORLDW DEF
   JOSEPH AEA, 1991, CLIN RADIOL, V43, P26, DOI 10.1016/S0009-9260(05)80350-2
   Kimm H, 2010, CIRC J, V74, P931, DOI 10.1253/circj.CJ-09-0571
   Lee CD, 1998, INT J OBESITY, V22, pS2
   Lee DC, 2011, BRIT J SPORT MED, V45, P504, DOI 10.1136/bjsm.2009.066209
   Lee DC, 2012, J AM COLL CARDIOL, V59, P665, DOI 10.1016/j.jacc.2011.11.013
   O'Donovan G, 2012, METABOLISM, V61, P213, DOI 10.1016/j.metabol.2011.06.009
   Racette SB, 2006, DIABETES CARE, V29, P673, DOI 10.2337/diacare.29.03.06.dc05-1605
   Rhéaume C, 2011, J CLIN ENDOCR METAB, V96, P1462, DOI 10.1210/jc.2010-2432
   Stepanova M, 2012, CLIN GASTROENTEROL H, V10, P646, DOI 10.1016/j.cgh.2011.12.039
   Stevens J, 2004, INT J OBESITY, V28, P1463, DOI 10.1038/sj.ijo.0802770
   Stevens J, 2002, AM J EPIDEMIOL, V156, P832, DOI 10.1093/aje/kwf114
   WHO, 2012, GLOBAL TUBERCULOSIS REPORT 2012, P1
   Wing RR, 2007, MED SCI SPORT EXER, V39, P2107, DOI 10.1249/mss.0b013e31815614cb
NR 25
TC 9
Z9 11
U1 0
U2 11
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
EI 1879-1913
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD APR 1
PY 2013
VL 111
IS 7
BP 991
EP 995
DI 10.1016/j.amjcard.2012.12.022
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 117AE
UT WOS:000316923700012
PM 23340029
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Todosenko, N
   Yurova, K
   Vulf, M
   Khaziakhmatova, O
   Malashchenko, V
   Khlusov, I
   Komar, A
   Kozlov, I
   Litvinova, L
AF Todosenko, Natalia
   Yurova, Kristina
   Vulf, Maria
   Khaziakhmatova, Olga
   Malashchenko, Vladimir
   Khlusov, Igor
   Komar, Alexandra
   Kozlov, Ivan
   Litvinova, Larisa
TI The Role of MicroRNAs in Mitochondrial Homeostasis and their Involvement
   in the Pathogenesis of Obesity and Metabolic Syndrome: A Focus on
   MicroRNAs
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review; Early Access
DE Mitochondria; metabolic syndrome; obesity; microRNAs; mitomicroRNAs;
   cell cultures
ID ADIPOSE-TISSUE INFLAMMATION; HEPATIC INSULIN-RESISTANCE; OXIDATIVE
   STRESS; SKELETAL-MUSCLE; DOWN-REGULATION; UP-REGULATION; MITO-PORTER;
   ISCHEMIA/REPERFUSION INJURY; LIPID-PEROXIDATION; ENERGY-METABOLISM
AB The maintenance of the functional potential of mitochondria is directly related to epigenetic factors, microRNAs (miRs), and mitomicroRNAs (mitomiRs). An important role in the development of metabolic syndrome (MetS)/obesity is attributed to miRs, which have pro-inflammatory or anti-inflammatory potential and can penetrate the mitochondrial matrix. Deciphering the mechanisms responsible for the transport of miRs into the mitochondria would, we believe, allow us to use the knowledge obtained to build designs for the transport of drugs/mitomiRs into cells/mitochondria with low toxicity. A thorough understanding of the polyfunctionality/versatility of individual mitomiRs in specific cells (cell cultures, tissues: adipocytes, brain cells) will allow targeting cellular metabolism to comprehensively block the central link in disease pathogenesis with low potential side effects of this treatment. In this review, we have attempted to identify the key miRs/mitomiRs associated with MetS that affect mitochondrial function. In our opinion, further research should focus specifically on the miR/mitomiRs described here and further investigate their potential in the development of MetS and its components.
C1 [Todosenko, Natalia; Yurova, Kristina; Vulf, Maria; Khaziakhmatova, Olga; Malashchenko, Vladimir; Khlusov, Igor; Komar, Alexandra; Litvinova, Larisa] Immanuel Kant Balt Fed Univ, Ctr Immunol & Cellular Biotechnol, Kaliningrad 236001, Russia.
   [Khlusov, Igor; Litvinova, Larisa] Siberian State Med Univ, Lab Cellular & Microfluid Technol, Tomsk 634050, Russia.
   [Kozlov, Ivan] IM Sechenov First Moscow State Med Univ, Inst Profess Educ, Moscow, Russia.
C3 Immanuel Kant Baltic Federal University; Siberian State Medical
   University; Sechenov First Moscow State Medical University
RP Litvinova, L (corresponding author), Immanuel Kant Balt Fed Univ, Ctr Immunol & Cellular Biotechnol, Kaliningrad 236001, Russia.
EM larisalitvinova@yandex.ru
RI Yurova, Kristina/F-7614-2017; Vulf, Maria/E-4926-2017; Malashchenko,
   Vladimir/F-8974-2017; Litvinova, Larisa/A-9672-2014; Todosenko,
   Natalia/P-6176-2017; Khaziakhmatova, Olga/F-7767-2017
FU Russian Science Foundation [23-15-00061]
FX This research was funded by Russian Science Foundation (project no.
   23-15-00061).
CR Abbade J, 2020, BMJ OPEN DIAB RES CA, V8, DOI 10.1136/bmjdrc-2019-000923
   Abedini Fatemeh, 2018, Microrna, V7, P74, DOI 10.2174/2211536607666180129153307
   Acharya A, 2019, GENE DEV, V33, P1367, DOI 10.1101/gad.328955.119
   Adam-Vizi V, 2006, TRENDS PHARMACOL SCI, V27, P639, DOI 10.1016/j.tips.2006.10.005
   Agrawal N, 2003, MICROBIOL MOL BIOL R, V67, P657, DOI 10.1128/MMBR.67.4.657-685.2003
   Ahmadpour F, 2018, ACTA ENDOCRINOL-BUCH, V14, P149, DOI 10.4183/aeb.2018.149
   Ahmed B, 2021, BIOMED PHARMACOTHER, V137, DOI 10.1016/j.biopha.2021.111315
   Akiyoshi K, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0256973
   Al Jalbout N, 2019, EMERG MED J, V36, P293, DOI 10.1136/emermed-2018-208002
   Andrieux P, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222111338
   [Anonymous], 2024, Patent, Patent No. [NCT05168774, 05168774]
   Antoniou A, 2023, CELL REP, V42, DOI 10.1016/j.celrep.2023.112063
   Aoi W, 2010, AM J PHYSIOL-ENDOC M, V298, pE799, DOI 10.1152/ajpendo.00448.2009
   Aras M, 2021, NURS CLIN N AM, V56, P527, DOI 10.1016/j.cnur.2021.07.008
   Arif A, 2022, NATURE, V608, P618, DOI 10.1038/s41586-022-05009-0
   Aschrafi A, 2012, CELL MOL LIFE SCI, V69, P4017, DOI 10.1007/s00018-012-1064-8
   Aschrafi A, 2008, J NEUROSCI, V28, P12581, DOI 10.1523/JNEUROSCI.3338-08.2008
   Atanesyan L, 2017, AM J CLIN PATHOL, V147, P60, DOI [10.1093/AJCP/AQW205, 10.1093/ajcp/aqw205]
   Atic AI, 2023, AM J PHYSIOL-CELL PH, V324, pC588, DOI 10.1152/ajpcell.00253.2022
   Banavath HN, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.119.012919
   Bandiera S, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020746
   Baradan R, 2017, CAN J PHYSIOL PHARM, V95, P1156, DOI 10.1139/cjpp-2016-0580
   Barrey E, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020220
   Bekkouche L, 2014, HORM METAB RES, V46, P274, DOI 10.1055/s-0033-1363657
   Benaroya H, 2020, REV NEUROSCIENCE, V31, P363, DOI 10.1515/revneuro-2019-0086
   Bhattacharjee J, 2021, ENDOCRINOLOGY, V162, DOI 10.1210/endocr/bqab007
   Bienertova-Vasku J, 2013, CANCER LETT, V336, P1, DOI 10.1016/j.canlet.2013.05.001
   Briones-Espinoza MJ, 2020, DIABETES METAB SYND, V14, P1347, DOI 10.1016/j.dsx.2020.07.014
   Bruce CR, 2012, DIABETES, V61, P3148, DOI 10.2337/db12-0029
   Bukeirat M, 2016, J CEREBR BLOOD F MET, V36, P387, DOI 10.1177/0271678X15606147
   Carrella S, 2022, EMBO MOL MED, V14, DOI 10.15252/emmm.202215941
   Carrer M, 2012, P NATL ACAD SCI USA, V109, P15330, DOI 10.1073/pnas.1207605109
   Carrier A, 2017, ANTIOXID REDOX SIGN, V26, P429, DOI 10.1089/ars.2016.6929
   Carroll AP, 2013, ANAL BIOCHEM, V437, P164, DOI 10.1016/j.ab.2013.02.022
   Cereijo R, 2020, OBES SURG, V30, P174, DOI 10.1007/s11695-019-04104-y
   Chandrasekar V, 2009, MOL CELL NEUROSCI, V42, P350, DOI 10.1016/j.mcn.2009.08.009
   Chartoumpekis DV, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034872
   Chen B, 2014, BMC CANCER, V14, DOI 10.1186/1471-2407-14-443
   Chen X, 2022, J DIABETES RES, V2022, DOI 10.1155/2022/9611509
   Chen XJ, 2022, HYPERTENS PREGNANCY, V41, P107, DOI 10.1080/10641955.2022.2056194
   Chen Y, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms11420
   Chernega T, 2022, MOL THER-NUCL ACIDS, V30, P359, DOI 10.1016/j.omtn.2022.10.012
   Choi SE, 2013, AGING CELL, V12, P1062, DOI 10.1111/acel.12135
   Choi WH, 2020, NUTR RES PRACT, V14, P412, DOI 10.4162/nrp.2020.14.4.412
   Colak E, 2021, J MED BIOCHEM, V40, P1, DOI 10.5937/jomb0-24652
   Colleoni F, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055194
   Collin F, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20102407
   Crépin D, 2014, MOL CELL ENDOCRINOL, V384, P1, DOI 10.1016/j.mce.2013.12.016
   Cui XL, 2022, CURR PHARM BIOTECHNO, V23, P1612, DOI 10.2174/1389201023666220324123224
   D SW, 2022, B EXP BIOL MED+, V173, P645, DOI 10.1007/s10517-022-05605-0
   Dai WT, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00570
   Dama A, 2024, NUTRIENTS, V16, DOI 10.3390/nu16040507
   Damase TR, 2021, FRONT BIOENG BIOTECH, V9, DOI 10.3389/fbioe.2021.628137
   Das M, 2021, ENDOCRINOLOGY, V162, DOI 10.1210/endocr/bqaa158
   Das S, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.116.004694
   Das S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0096820
   Dasgupta N, 2015, CELL DEATH DISCOV, V1, DOI 10.1038/cddiscovery.2015.4
   de Bem AF, 2021, FRONT NEUROSCI-SWITZ, V14, DOI 10.3389/fnins.2020.604150
   de Mello AH, 2018, LIFE SCI, V192, P26, DOI 10.1016/j.lfs.2017.11.019
   Dou L, 2017, CELL PHYSIOL BIOCHEM, V41, P2419, DOI 10.1159/000475912
   Dowling L, 2022, J CACHEXIA SARCOPENI, V13, P68, DOI 10.1002/jcsm.12878
   Du XR, 2024, MITOCHONDRION, V75, DOI 10.1016/j.mito.2024.101846
   Duarte FV, 2015, ADV EXP MED BIOL, V888, P123, DOI 10.1007/978-3-319-22671-2_8
   Duroux-Richard I, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.738140
   El Sherbiny S, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12071427
   Endisha H, 2021, ARTHRITIS RHEUMATOL, V73, P426, DOI 10.1002/art.41552
   Fan F, 2017, ONCOTARGET, V8, P110209, DOI 10.18632/oncotarget.22597
   Fan S, 2019, CANCER RES, V79, P1069, DOI 10.1158/0008-5472.CAN-18-2505
   Fang ZJ, 2016, INT J MOL MED, V38, P845, DOI 10.3892/ijmm.2016.2659
   Farahani RA, 2020, STEM CELL REV REP, V16, P933, DOI 10.1007/s12015-020-09988-3
   Farr OM, 2015, METABOLISM, V64, P114, DOI 10.1016/j.metabol.2014.07.004
   Feng YY, 2014, CELL PHYSIOL BIOCHEM, V34, P1983, DOI 10.1159/000366394
   Forrester SJ, 2018, CIRC RES, V122, P877, DOI 10.1161/CIRCRESAHA.117.311401
   Fu T, 2016, VITAM HORM, V101, P175, DOI 10.1016/bs.vh.2016.02.002
   Fu XH, 2015, J CLIN INVEST, V125, P2497, DOI 10.1172/JCI75438
   Gao JW, 2023, CLIN SCI, V137, P495, DOI 10.1042/CS20220833
   Gao KX, 2021, CELL RES, V31, P219, DOI 10.1038/s41422-020-00394-5
   García-García I, 2014, OBES REV, V15, P853, DOI 10.1111/obr.12221
   Gaschler MM, 2017, BIOCHEM BIOPH RES CO, V482, P419, DOI 10.1016/j.bbrc.2016.10.086
   Gee HE, 2014, ANTIOXID REDOX SIGN, V21, P1220, DOI 10.1089/ars.2013.5639
   Geiger J, 2017, CELL MOL LIFE SCI, V74, P631, DOI 10.1007/s00018-016-2342-7
   Gharanei S, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9112489
   Giordani C, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.734976
   Giuliani A, 2018, AGING-US, V10, P2855, DOI 10.18632/aging.101591
   Golden RJ, 2017, NATURE, V542, P197, DOI 10.1038/nature21025
   González-Domínguez A, 2023, REV ENDOCR METAB DIS, V24, P1147, DOI 10.1007/s11154-023-09834-0
   Gonzalez-Franquesa A, 2017, ADV EXP MED BIOL, V982, P465, DOI 10.1007/978-3-319-55330-6_25
   Granados-Riveron JT, 2021, BIOMED PHARMACOTHER, V142, DOI 10.1016/j.biopha.2021.111953
   Granata S, 2023, CLIN KIDNEY J, V16, P2349, DOI 10.1093/ckj/sfad196
   Grant RW, 2011, PHYSIOL GENOMICS, V43, P295, DOI 10.1152/physiolgenomics.00190.2010
   Grimm A, 2017, J NEUROCHEM, V143, P418, DOI 10.1111/jnc.14037
   Grundy SM, 2016, TRENDS CARDIOVAS MED, V26, P364, DOI 10.1016/j.tcm.2015.10.004
   Guduric-Fuchs J, 2012, BMC GENOMICS, V13, DOI 10.1186/1471-2164-13-357
   GUEZENNEC CY, 1994, EUR J APPL PHYSIOL, V68, P525, DOI 10.1007/BF00599524
   Gutteridge JMC, 2018, BIOCHEM BIOPH RES CO, V502, P183, DOI 10.1016/j.bbrc.2018.05.045
   Hale A, 2014, BBA-MOL CELL RES, V1843, P2528, DOI 10.1016/j.bbamcr.2014.06.012
   Han HS, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01878-6
   Harries L, 2019, NATURE, V574, pS15, DOI 10.1038/d41586-019-03074-6
   Hastie R, 2014, PLACENTA, V35, P673, DOI 10.1016/j.placenta.2014.06.368
   Hellwig S, 2016, BRAIN BEHAV IMMUN, V55, P126, DOI 10.1016/j.bbi.2015.11.008
   Heyn GS, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.563816
   Hijmans Jamie G, 2018, Microrna, V7, P148, DOI 10.2174/2211536607666180402120806
   Ho PTB, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23137167
   Hoehn KL, 2009, P NATL ACAD SCI USA, V106, P17787, DOI 10.1073/pnas.0902380106
   Hromadnikova I, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21218413
   Hu H, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-59997-y
   Hu TT, 2021, FRONT BIOENG BIOTECH, V9, DOI 10.3389/fbioe.2021.786621
   Huang CJ, 2015, SPORTS MED-OPEN, V1, DOI 10.1186/s40798-015-0031-y
   Huang JL, 2021, FRONT CELL DEV BIOL, V9, DOI 10.3389/fcell.2021.688523
   Huang L, 2011, J BIOL CHEM, V286, P24219, DOI 10.1074/jbc.M111.240259
   Huang YX, 2018, BIOMED RES INT, V2018, DOI 10.1155/2018/7372636
   Huberdeau MQ, 2017, EMBO J, V36, P2088, DOI 10.15252/embj.201696386
   Hulsmans M, 2012, J CLIN ENDOCR METAB, V97, pE1213, DOI 10.1210/jc.2012-1008
   Hulsmans M, 2011, FASEB J, V25, P2515, DOI 10.1096/fj.11-181149
   Hutchison ER, 2013, GLIA, V61, P1018, DOI 10.1002/glia.22483
   Indrieri A, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21062092
   Infante-Menéndez J, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9070607
   Irazabal MV, 2022, CLIN SCI, V136, P345, DOI 10.1042/CS20210512
   Jadhav V, 2024, NAT BIOTECHNOL, DOI 10.1038/s41587-023-02105-y
   Jagannathan R, 2015, CIRC-CARDIOVASC GENE, V8, P785, DOI 10.1161/CIRCGENETICS.115.001067
   Jakubczyk Karolina, 2020, Pol Merkur Lekarski, V48, P124
   Jeandard D, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8030286
   Ji X, 2023, BRAIN RES BULL, V195, P14, DOI 10.1016/j.brainresbull.2023.01.002
   Jia YZ, 2022, FRONT ONCOL, V12, DOI 10.3389/fonc.2022.830420
   Jia YZ, 2023, OBESITY, V31, P2972, DOI 10.1002/oby.23884
   Jiang FJ, 2020, J HEPATOL, V72, P156, DOI 10.1016/j.jhep.2019.09.014
   Jiang J, 2018, HUM CELL, V31, P282, DOI 10.1007/s13577-018-0210-5
   Jiang XY, 2014, CELL PHYSIOL BIOCHEM, V33, P1778, DOI 10.1159/000362957
   Jiang Y, 2015, J NEUROCHEM, V134, P173, DOI 10.1111/jnc.13097
   John A, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9061345
   Joseph LC, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0145750
   Juan CA, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22094642
   Jung SE, 2021, EXP MOL MED, V53, P1332, DOI 10.1038/s12276-021-00665-0
   Jusic A, 2020, BASIC RES CARDIOL, V115, DOI 10.1007/s00395-020-0783-5
   Kamaly N, 2012, CHEM SOC REV, V41, P2971, DOI 10.1039/c2cs15344k
   KAMOLRATANAKUL P, 1992, AM J TROP MED HYG, V47, P554, DOI 10.4269/ajtmh.1992.47.554
   Kang T, 2013, J BIOL CHEM, V288, P34394, DOI 10.1074/jbc.M113.514372
   Karbiener M, 2014, STEM CELLS, V32, P1578, DOI 10.1002/stem.1603
   Kelley DE, 2002, DIABETES, V51, P2944, DOI 10.2337/diabetes.51.10.2944
   Khan MS, 2024, DRUG DISCOV TODAY, V29, DOI 10.1016/j.drudis.2023.103819
   Khan T, 2022, PHARMACEUTICS, V14, DOI 10.3390/pharmaceutics14122657
   Kiran S, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10051004
   Kobayashi A, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24119414
   Koh EH, 2018, DIABETES, V67, P2541, DOI 10.2337/db17-1378
   Kozloski GA, 2016, BLOOD, V127, P2856, DOI 10.1182/blood-2015-11-680462
   Kren BT, 2009, RNA BIOL, V6, P65, DOI 10.4161/rna.6.1.7534
   Krycer JR, 2020, J BIOL CHEM, V295, P99, DOI 10.1074/jbc.RA119.011695
   Kulkarni SS, 2016, DIABETES, V65, P3552, DOI 10.2337/db15-1725
   Kuthethur R, 2022, J CELL SCI, V135, DOI 10.1242/jcs.258937
   Kuzuoglu-Öztürk D, 2016, EMBO J, V35, P1186, DOI 10.15252/embj.201592901
   Langi G, 2019, J CLIN MED, V8, DOI 10.3390/jcm8081220
   Lee H, 2017, J BIOL CHEM, V292, P7115, DOI 10.1074/jbc.M116.762567
   Lee H, 2017, BMB REP, V50, P214, DOI 10.5483/BMBRep.2017.50.4.006
   Lee H, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.670076
   Lee M, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-37765-3
   Lemecha M, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-33438-3
   Lhamyani S, 2024, BIOMED PHARMACOTHER, V171, DOI 10.1016/j.biopha.2023.116104
   Lhamyani S, 2021, MOL THER NUCL ACIDS, V26, P401, DOI 10.1016/j.omtn.2021.06.019
   Li B, 2020, PROG LIPID RES, V77, DOI 10.1016/j.plipres.2019.101020
   Li F, 2024, CURR PHARM BIOTECHNO, V25, P1858, DOI 10.2174/0113892010266863231030052150
   Li HP, 2019, MOL THER-NUCL ACIDS, V17, P424, DOI 10.1016/j.omtn.2019.06.013
   Li J, 2022, PLACENTA, V121, P126, DOI 10.1016/j.placenta.2022.02.013
   Li J, 2012, BMC MOL BIOL, V13, DOI 10.1186/1471-2199-13-4
   Li PF, 2012, J CELL BIOCHEM, V113, P1104, DOI 10.1002/jcb.24004
   Li QOY, 2017, ADIPOCYTE, V6, P161, DOI 10.1080/21623945.2017.1297346
   Li XQ, 2024, RNA BIOL, V21, P1, DOI 10.1080/15476286.2023.2293343
   Liang LQ, 2023, FASEB J, V37, DOI 10.1096/fj.202201202RR
   Liao JW, 2021, EAT WEIGHT DISORD-ST, V26, P457, DOI 10.1007/s40519-020-00869-9
   Liaudanskaya V, 2023, CELL DEATH DIS, V14, DOI 10.1038/s41419-023-05980-0
   Lim S, 2023, AM J PHYSIOL-CELL PH, V324, pC1101, DOI 10.1152/ajpcell.00071.2023
   Lin CL, 2012, NUCLEIC ACIDS RES, V40, P4146, DOI 10.1093/nar/gkr1281
   Liu HY, 2020, EUR REV MED PHARMACO, V24, P10069, DOI 10.26355/eurrev_202010_23224
   Liu J, 2016, EMBO MOL MED, V8, P1212, DOI 10.15252/emmm.201606372
   Liu LL, 2024, J TRANSL MED, V22, DOI 10.1186/s12967-024-05330-4
   Liu XF, 2024, J CLIN ENDOCR METAB, V109, P815, DOI 10.1210/clinem/dgad562
   Long B, 2013, FREE RADICAL BIO MED, V65, P371, DOI 10.1016/j.freeradbiomed.2013.07.009
   Blanco ALY, 2022, NUTRIENTS, V14, DOI 10.3390/nu14040746
   Lu Y, 2017, EXP THER MED, V13, P1697, DOI 10.3892/etm.2017.4161
   Luo L, 2024, FRONT PHYSIOL, V14, DOI 10.3389/fphys.2023.1279548
   Lyu Yanni, 2015, Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, V31, P1042
   Ma LH, 2016, J CHIN MED ASSOC, V79, P597, DOI 10.1016/j.jcma.2016.08.006
   Ma QY, 2019, MOL NEUROBIOL, V56, P5608, DOI 10.1007/s12035-019-1491-8
   Ma ZY, 2023, BIOMATERIALS, V293, DOI 10.1016/j.biomaterials.2022.121947
   Macgregor-Das AM, 2018, AM J PHYSIOL-HEART C, V315, pH206, DOI 10.1152/ajpheart.00714.2017
   Estévez-Cabrera MM, 2023, HELIYON, V9, DOI 10.1016/j.heliyon.2023.e13442
   Maghsoudni N, 2020, J DRUG TARGET, V28, P818, DOI 10.1080/1061186X.2020.1774594
   Manna P, 2015, METAB SYNDR RELAT D, V13, P423, DOI 10.1089/met.2015.0095
   Mao CP, 2014, J CELL MOL MED, V18, P2404, DOI 10.1111/jcmm.12420
   Marrache S, 2012, P NATL ACAD SCI USA, V109, P16288, DOI 10.1073/pnas.1210096109
   Marseglia L, 2015, INT J MOL SCI, V16, P378, DOI 10.3390/ijms16010378
   Marzano F, 2018, PEDIATR OBES, V13, P803, DOI 10.1111/ijpo.12439
   Maslov LN, 2019, J CLIN TRANSL ENDOCR, V15, P1, DOI 10.1016/j.jcte.2018.11.001
   Matveev GA, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms241713426
   McKenzie AJ, 2016, CELL REP, V15, P978, DOI 10.1016/j.celrep.2016.03.085
   Meister G, 2013, NAT REV GENET, V14, P447, DOI 10.1038/nrg3462
   Mela V, 2023, NUTRIENTS, V15, DOI 10.3390/nu15194109
   Meloni M, 2013, MOL THER, V21, P1390, DOI 10.1038/mt.2013.89
   Meng Y, 2018, J CELL PHYSIOL, V233, P5926, DOI 10.1002/jcp.26402
   Mercer TR, 2011, CELL, V146, P645, DOI 10.1016/j.cell.2011.06.051
   Mittal M, 2014, ANTIOXID REDOX SIGN, V20, P1126, DOI 10.1089/ars.2012.5149
   Montgomery MK, 2015, ENDOCR CONNECT, V4, DOI 10.1530/EC-14-0092
   Moosavian SA, 2019, CANCER LETT, V448, P144, DOI 10.1016/j.canlet.2019.01.045
   Morente-López M, 2023, STEM CELL RES THER, V14, DOI 10.1186/s13287-023-03613-z
   Mulard ED, 2024, NUTRIENTS, V16, DOI 10.3390/nu16060803
   Mun J, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057850
   Muralimanoharan S, 2015, INT J OBESITY, V39, P1274, DOI 10.1038/ijo.2015.45
   Murdolo G, 2013, BIOCHIMIE, V95, P585, DOI 10.1016/j.biochi.2012.12.014
   Murphy MP, 1997, TRENDS BIOTECHNOL, V15, P326, DOI 10.1016/S0167-7799(97)01068-8
   Murri M, 2018, AM J PHYSIOL-HEART C, V315, pH291, DOI 10.1152/ajpheart.00691.2017
   Mushtaq I, 2023, ARCH BIOCHEM BIOPHYS, V747, DOI 10.1016/j.abb.2023.109763
   Nakanishi K, 2022, NUCLEIC ACIDS RES, V50, P6618, DOI 10.1093/nar/gkac519
   Narwade M, 2023, BIOMATER RES, V27, DOI 10.1186/s40824-023-00365-y
   Nasci VL, 2019, AM J PHYSIOL-HEART C, V316, pH710, DOI 10.1152/ajpheart.00538.2017
   Neupane Prashant, 2019, BioMolecular Concepts, V10, P1, DOI 10.1515/bmc-2019-0001
   Nguyen DDN, 2021, AM J PHYSIOL-HEART C, V321, pH770, DOI 10.1152/ajpheart.00058.2021
   Nolfi-Donegan D, 2020, REDOX BIOL, V37, DOI 10.1016/j.redox.2020.101674
   Opsahl JO, 2021, J DEV ORIG HLTH DIS, V12, P373, DOI 10.1017/S2040174420000811
   Oses M, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122890
   Pan D, 2023, GASTROENT RES PRACT, V2023, DOI 10.1155/2023/6973723
   Pan DN, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms5725
   Pan Y, 2019, J CLIN INVEST, V129, P834, DOI 10.1172/JCI123069
   Panda SP, 2023, MITOCHONDRION, V71, P1, DOI 10.1016/j.mito.2023.05.003
   Patra D, 2024, J BIOL CHEM, V300, DOI 10.1016/j.jbc.2024.107328
   Patra D, 2023, DIABETES, V72, P375, DOI 10.2337/db22-0284
   Paunovska K, 2022, NAT REV GENET, V23, P265, DOI 10.1038/s41576-021-00439-4
   Pawar A, 2021, CURR DRUG DELIV, V18, P1044, DOI 10.2174/1567201818999210120201252
   Payne CT, 2023, FRONT CELL NEUROSCI, V17, DOI 10.3389/fncel.2023.1278334
   Pereira RO, 2022, DIABETES, V71, P2572, DOI 10.2337/db22-0450
   Mayoral LPC, 2020, INDIAN J MED RES, V151, P11, DOI 10.4103/ijmr.IJMR_1768_17
   Pesta D, 2017, CURR DIABETES REP, V17, DOI 10.1007/s11892-017-0867-2
   Petersen MC, 2017, TRENDS PHARMACOL SCI, V38, P649, DOI 10.1016/j.tips.2017.04.004
   Politis-Barber V, 2020, AM J PHYSIOL-ENDOC M, V319, pE376, DOI 10.1152/ajpendo.00028.2020
   Povero D, 2015, CELL MOL GASTROENTER, V1, P646, DOI 10.1016/j.jcmgh.2015.07.007
   Prakash S, 2023, EUR J DRUG METAB PH, V48, P515, DOI 10.1007/s13318-023-00849-1
   Prasun P, 2020, BBA-MOL BASIS DIS, V1866, DOI 10.1016/j.bbadis.2020.165838
   Purohit PK, 2021, CELL MOL LIFE SCI, V78, P1405, DOI 10.1007/s00018-020-03670-0
   Qin JB, 2021, NANOSCALE, V13, P7108, DOI 10.1039/d1nr01068a
   Qiu M, 2021, P NATL ACAD SCI USA, V118, DOI 10.1073/pnas.2020401118
   Qu CD, 2020, IUBMB LIFE, V72, P465, DOI 10.1002/iub.2212
   Queiroz AL, 2021, MOL METAB, V51, DOI 10.1016/j.molmet.2021.101226
   Quirós PM, 2012, EMBO J, V31, P2117, DOI 10.1038/emboj.2012.70
   Rakib A, 2022, IMMUN AGEING, V19, DOI 10.1186/s12979-022-00320-w
   Ramkhelawon B, 2014, NAT MED, V20, P377, DOI 10.1038/nm.3467
   Ren XF, 2019, NEUROCHEM INT, V127, P73, DOI 10.1016/j.neuint.2018.10.019
   Rippo MR, 2014, EXP GERONTOL, V56, P154, DOI 10.1016/j.exger.2014.03.002
   Ritov VB, 2005, DIABETES, V54, P8, DOI 10.2337/diabetes.54.1.8
   Rivera J, 2023, CELLS-BASEL, V12, DOI 10.3390/cells12050742
   Rocha M, 2020, TRENDS ENDOCRIN MET, V31, P725, DOI 10.1016/j.tem.2020.03.004
   Rodrigues AC, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.676265
   Rodrigues PM, 2023, LIVER INT, V43, P2256, DOI 10.1111/liv.15682
   Rodrigues SC, 2020, BIOLOGY-BASEL, V9, DOI 10.3390/biology9120486
   Rogne M, 2018, MOL BIOL CELL, V29, P1487, DOI 10.1091/mbc.E17-09-0538
   Roiz-Valle D, 2023, MECH AGEING DEV, V212, DOI 10.1016/j.mad.2023.111822
   Roman B, 2020, J MOL CELL CARDIOL, V144, P87, DOI 10.1016/j.yjmcc.2020.05.009
   Roszczyc-Owsiejczuk K, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.635175
   Roy D, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms231911036
   Rudich A, 1998, DIABETES, V47, P1562, DOI 10.2337/diabetes.47.10.1562
   Sacco J, 2012, CURR OPIN LIPIDOL, V23, P220, DOI 10.1097/MOL.0b013e3283534c9f
   Saha PK, 2020, AM J PHYSIOL-ENDOC M, V319, pE667, DOI 10.1152/ajpendo.00045.2020
   Salinas T, 2006, P NATL ACAD SCI USA, V103, P18362, DOI 10.1073/pnas.0606449103
   Samangouei Parisa, 2018, Cond Med, V1, P239
   Samson SL, 2014, ENDOCRIN METAB CLIN, V43, P1, DOI 10.1016/j.ecl.2013.09.009
   Sarkar S, 2016, BRAIN RES, V1646, P139, DOI 10.1016/j.brainres.2016.05.026
   Sasaki T, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17071081
   Scioli MG, 2020, J CLIN MED, V9, DOI 10.3390/jcm9061995
   Seyhan AA, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25031469
   Shaito A, 2022, FRONT BIOSCI-LANDMRK, V27, DOI 10.31083/j.fbl2703105
   Sharma K, 2021, MITOCHONDRION, V60, P160, DOI 10.1016/j.mito.2021.08.008
   Shepherd DL, 2017, J MOL CELL CARDIOL, V110, P15, DOI 10.1016/j.yjmcc.2017.06.012
   Sheu-Gruttadauria J, 2019, MOL CELL, V75, P1243, DOI 10.1016/j.molcel.2019.06.019
   Shinde S, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/206382
   Singh A, 2021, EBIOMEDICINE, V65, DOI 10.1016/j.ebiom.2021.103244
   Singh A, 2019, MOLECULES, V24, DOI 10.3390/molecules24081583
   Song XM, 2021, J STROKE CEREBROVASC, V30, DOI 10.1016/j.jstrokecerebrovasdis.2020.105485
   Sorensen AE, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10010170
   Spahis S, 2017, ANTIOXID REDOX SIGN, V26, P445, DOI 10.1089/ars.2016.6756
   Sprenkle NT, 2023, CELL REP, V42, DOI 10.1016/j.celrep.2023.112928
   Srinivasan H, 2015, CAN J PHYSIOL PHARM, V93, P855, DOI 10.1139/cjpp-2014-0500
   Su ZQ, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.01193
   Sud N, 2017, J NUTR BIOCHEM, V43, P125, DOI 10.1016/j.jnutbio.2017.02.003
   Sun H, 2023, EXP MOL MED, V55, P1974, DOI 10.1038/s12276-023-01072-3
   Sun W, 2017, CELL PHYSIOL BIOCHEM, V43, P383, DOI 10.1159/000480417
   Sun WH, 2022, BIOMOLECULES, V12, DOI 10.3390/biom12121863
   Sun XH, 2016, CIRC RES, V118, P810, DOI 10.1161/CIRCRESAHA.115.308166
   Tai YS, 2021, LIFE SCI, V276, DOI 10.1016/j.lfs.2021.119415
   Tak H, 2014, EXP MOL MED, V46, DOI 10.1038/emm.2014.73
   Tangvarasittichai S, 2015, WORLD J DIABETES, V6, P456, DOI 10.4239/wjd.v6.i3.456
   Tao YL, 2023, INT J NANOMED, V18, P4705, DOI 10.2147/IJN.S419081
   Ti DD, 2016, SCI CHINA LIFE SCI, V59, P1305, DOI 10.1007/s11427-016-0240-4
   Tian JJ, 2023, J MOL HISTOL, V54, P543, DOI 10.1007/s10735-023-10158-1
   Todosenko Natalia, 2024, Gene Expression-The Journal of Liver Research, V23, P127, DOI 10.14218/GE.2023.00202
   Todosenko N, 2024, FRONT MOL BIOSCI, V11, DOI 10.3389/fmolb.2024.1322687
   Torres JL, 2022, J GASTROINTEST SURG, V26, P286, DOI 10.1007/s11605-021-05216-6
   Touyz RM, 2020, CAN J CARDIOL, V36, P659, DOI 10.1016/j.cjca.2020.02.081
   Varghese JF, 2018, CURR CARDIOL REV, V14, P4, DOI 10.2174/1573403X13666171009112250
   Varra FN, 2024, MOL MED REP, V29, DOI 10.3892/mmr.2024.13219
   Vasudevan S, 2012, WIRES RNA, V3, P311, DOI 10.1002/wrna.121
   Veith Alex, 2018, Current Opinion in Toxicology, V7, P44, DOI 10.1016/j.cotox.2017.10.003
   Vernier M, 2021, J MOL ENDOCRINOL, V66, pR1, DOI 10.1530/JME-20-0196
   Vinothkumar KR, 2014, NATURE, V515, P80, DOI 10.1038/nature13686
   Wan FX, 2023, BMC CARDIOVASC DISOR, V23, DOI 10.1186/s12872-023-03502-6
   Wang CH, 2017, J BIOMED SCI, V24, DOI 10.1186/s12929-017-0375-3
   Wang CH, 2015, ANN NY ACAD SCI, V1350, P66, DOI 10.1111/nyas.12838
   Wang FX, 2020, MOL MED REP, V21, P2405, DOI 10.3892/mmr.2020.11065
   Wang HY, 2023, BMC PHARMACOL TOXICO, V24, DOI 10.1186/s40360-023-00654-1
   Wang HJ, 2015, J CELL MOL MED, V19, P2084, DOI 10.1111/jcmm.12563
   Wang HM, 2016, CYTOTECHNOLOGY, V68, P839, DOI 10.1007/s10616-014-9837-6
   Wang JX, 2011, NAT MED, V17, P71, DOI 10.1038/nm.2282
   Wang K, 2012, NAT COMMUN, V3, DOI 10.1038/ncomms1770
   Wang L, 2017, INT J BIOL SCI, V13, P76, DOI 10.7150/ijbs.17278
   Wang L, 2015, CELL PHYSIOL BIOCHEM, V36, P2357, DOI 10.1159/000430198
   Wang LF, 2020, CELL, V183, P684, DOI 10.1016/j.cell.2020.09.017
   Wang WX, 2020, MOL NEUROBIOL, V57, P2996, DOI 10.1007/s12035-020-01937-y
   Wang WX, 2015, EXP NEUROL, V265, P84, DOI 10.1016/j.expneurol.2014.12.018
   Wang ZJ, 2017, ASIAN J PHARM SCI, V12, P498, DOI 10.1016/j.ajps.2017.05.006
   Weissig Volkmar, 2015, Methods Mol Biol, V1265, P1, DOI 10.1007/978-1-4939-2288-8_1
   Wirth C, 2016, BBA-BIOENERGETICS, V1857, P902, DOI 10.1016/j.bbabio.2016.02.013
   Wlodarski A, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21186902
   Xiao J, 2020, J AGR FOOD CHEM, V68, P12284, DOI 10.1021/acs.jafc.0c04539
   Xu LL, 2014, CELL BIOCHEM BIOPHYS, V70, P771, DOI 10.1007/s12013-014-9980-x
   Xu XB, 2023, EXP NEUROL, V359, DOI 10.1016/j.expneurol.2022.114235
   Xu YY, 2021, MOL METAB, V51, DOI 10.1016/j.molmet.2021.101244
   Yamada Y, 2008, BBA-BIOMEMBRANES, V1778, P423, DOI 10.1016/j.bbamem.2007.11.002
   Yamada Y, 2016, J PHARM SCI-US, V105, P1705, DOI 10.1016/j.xphs.2016.03.002
   Yamada Y, 2015, MITOCHONDRION, V24, P50, DOI 10.1016/j.mito.2015.07.003
   Yamada Y, 2015, J CONTROL RELEASE, V213, P86, DOI 10.1016/j.jconrel.2015.06.037
   Yan KW, 2019, CELL DEATH DIS, V10, DOI 10.1038/s41419-019-1734-7
   Yang YY, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/5477024
   Yu AM, 2022, PHARMACOL THERAPEUT, V230, DOI 10.1016/j.pharmthera.2021.107967
   Yuzbashian E, 2022, EAT WEIGHT DISORD-ST, V27, P3419, DOI 10.1007/s40519-022-01476-6
   Zhai Y, 2022, KAOHSIUNG J MED SCI, V38, P367, DOI 10.1002/kjm2.12486
   Zhang C, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05870-6
   Zhang CXW, 2024, TRENDS ENDOCRIN MET, V35, P638, DOI 10.1016/j.tem.2024.02.002
   Zhang HS, 2022, FEBS OPEN BIO, V12, P1828, DOI 10.1002/2211-5463.13471
   Zhang H, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/6114132
   Zhang JJ, 2018, MECH AGEING DEV, V169, P10, DOI 10.1016/j.mad.2017.12.001
   Zhang JJ, 2017, MECH AGEING DEV, V164, P8, DOI 10.1016/j.mad.2017.03.009
   Zhang LX, 2019, REDOX BIOL, V26, DOI 10.1016/j.redox.2019.101284
   Zhang NN, 2017, MOL MED REP, V16, P2254, DOI 10.3892/mmr.2017.6769
   Zhang S, 2021, THERANOSTICS, V11, P614, DOI 10.7150/thno.47007
   Zhang SZ, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18030633
   Zhang TP, 2019, J HEPATOL, V70, P87, DOI 10.1016/j.jhep.2018.08.026
   Zhang XR, 2014, CELL, V158, P607, DOI 10.1016/j.cell.2014.05.047
   Zhang ZJ, 2018, METABOLISM, V88, P31, DOI 10.1016/j.metabol.2018.08.007
   Zhang ZP, 2020, J CELL BIOCHEM, V121, P3825, DOI 10.1002/jcb.29539
   Zhao JF, 2022, HEPATOL COMMUN, V6, P1301, DOI 10.1002/hep4.1892
   Zhao W, 2015, MOL BIOL CELL, V26, P1786, DOI 10.1091/mbc.E14-10-1474
   Zhao Yong-cai, 2015, Zhongguo Ying Yong Sheng Li Xue Za Zhi, V31, P259
   Zheng Li-Fang, 2019, Shengli Xuebao, V71, P497, DOI 10.13294/j.aps.2018.0061
   Zhu J, 2019, FEMS MICROBIOL LETT, V366, DOI 10.1093/femsle/fnaa015
   Zhu Z, 2017, BRAZ J MED BIOL RES, V50, DOI [10.1590/1414-431X20175817, 10.1590/1414-431x20175817]
   Zielonka J, 2017, CHEM REV, V117, P10043, DOI 10.1021/acs.chemrev.7b00042
   Zorzano Antonio, 2009, Archives of Physiology and Biochemistry, V115, P1, DOI 10.1080/13813450802676335
   Zou B, 2015, EUR J NUTR, V54, P1333, DOI 10.1007/s00394-014-0814-9
NR 354
TC 0
Z9 0
U1 0
U2 0
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PD 2025 MAR 7
PY 2025
DI 10.2174/0109298673361354250224060829
EA MAR 2025
PG 32
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 2DR5P
UT WOS:001480187300001
PM 40059425
DA 2025-06-11
ER

PT J
AU Finicelli, M
   Squillaro, T
   Di Cristo, F
   Di Salle, A
   Melone, MAB
   Galderisi, U
   Peluso, G
AF Finicelli, Mauro
   Squillaro, Tiziana
   Di Cristo, Francesca
   Di Salle, Anna
   Melone, Mariarosa Anna Beatrice
   Galderisi, Umberto
   Peluso, Gianfranco
TI Metabolic syndrome, Mediterranean diet, and polyphenols: Evidence and
   perspectives
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Review
DE Mediterranean diet; metabolic syndrome; olive oil; polyphenols;
   resveratrol
ID VIRGIN OLIVE OIL; OXIDATIVE STRESS; INSULIN-RESISTANCE; ADIPOSE-TISSUE;
   CHLOROGENIC ACID; FATTY-ACIDS; ENDOTHELIAL DYSFUNCTION;
   MITOCHONDRIAL-FUNCTION; MYOCARDIAL-INFARCTION; POSSIBLE INVOLVEMENT
AB Metabolic syndrome (MetS) is defined as the co-occurrence of metabolic risk factors that includes insulin resistance, hyperinsulinemia, impaired glucose tolerance, type 2 diabetes mellitus, dyslipidemia, and visceral obesity. The clinical significance of MetS consists of identifying a subgroup of patients sharing a common physiopathological state predisposing to chronic diseases. Clinical and scientific studies pinpoint lifestyle modification as an effective strategy aiming to reduce several features accountable for the risk of MetS onset. Among the healthy dietary patterns, the Mediterranean diet (MedDiet) emerges in terms of beneficial properties associated with longevity. Current evidence highlights the protective effect exerted by MedDiet on the different components of MetS. Interestingly, the effect exerted by polyphenols contained within the representative MedDiet components (i.e., olive oil, red wine, and nuts) seems to be accountable for the beneficial properties associated to this dietary pattern. In this review, we aim to summarize the principal evidence regarding the effectiveness of MedDiet-polyphenols in preventing or delaying the physiopathological components accountable for MetS onset. These findings may provide useful insights concerning the health properties of MedDiet-polyphenols as well as the novel targets destined to a tailored approach to MetS.
C1 [Finicelli, Mauro; Di Salle, Anna; Peluso, Gianfranco] CNR, Inst Agrienvironm Biol & Forestry IBAF, Via P Castellino 111, I-80131 Naples, Italy.
   [Squillaro, Tiziana; Melone, Mariarosa Anna Beatrice] Univ Campania Luigi Vanvitelli, Dept Med Surg Neurol Metab Sci & Aging, Div Neurol 2, Ctr Rare Dis, Naples, Italy.
   [Squillaro, Tiziana; Melone, Mariarosa Anna Beatrice] Univ Campania Luigi Vanvitelli, InterUniv Ctr Res Neurosci, Naples, Italy.
   [Di Cristo, Francesca] Elleva Pharma Srl, Via S Fancesco dAssisi, Naples, Italy.
   [Galderisi, Umberto] Univ Campania Luigi Vanvitelli, Dept Expt Med, Biotechnol & Mol Biol Sect, Naples, Italy.
   [Melone, Mariarosa Anna Beatrice; Galderisi, Umberto] Temple Univ, Dept Biol, Coll Sci & Technol, Sbarro Inst Canc Res & Mol Med,Ctr Biotechnol, Philadelphia, PA 19122 USA.
C3 Consiglio Nazionale delle Ricerche (CNR); Universita della Campania
   Vanvitelli; Universita della Campania Vanvitelli; Universita della
   Campania Vanvitelli; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); Temple University
RP Peluso, G (corresponding author), CNR, Inst Agrienvironm Biol & Forestry IBAF, Via P Castellino 111, I-80131 Naples, Italy.
EM gianfranco.peluso@ibaf.cnr.it
RI Di Cristo, Francesca/AEN-6072-2022; Di Salle, A/AAF-5416-2019;
   Finicelli, Mauro/ABC-1392-2020; Melone, Mariarosa AB/N-6788-2015
OI Melone, Mariarosa AB/0000-0002-7213-9277; Di Salle,
   Anna/0000-0001-6763-3636; Di Cristo, Francesca/0000-0002-4544-6837;
   Finicelli, Mauro/0000-0003-2289-0916
FU PO FESR 2014-2020 - Regione Campania, Asse 1 - obiettivo specifico 1.2,
   Progetto "Sviluppo di nanotecnologie Orientate alla Rigenerazione e
   Ricostruzione tissutale, Implantologia e Sensoristica in Odontoiatria"
   oculistica (SORRISO)" [pdt1-000410]; Project " Studio di fattibilita per
   la progettazione di sistemi di rilascio nanoparticellari a base di
   idrossidi doppi lamellari (layered double hyroxide-LDH) in grado di
   veicolare, in modo controllato e prolungato nel tempo, molecole
   biologicamente attive [N. 0000836/2018]; PON IAMP;C 2014-2020 FESR
   progetto "Micro/nanoformulati innovativi per la valorizzazione di
   molecole bioattive, utili per la salute e il benessere delle
   popolazione, ottenute da prodotti di scarto della filiera ittica
   (FORTUNA)" [F/050347/03IX32]
FX PO FESR 2014-2020 - Regione Campania, Asse 1 - obiettivo specifico 1.2,
   Progetto "Sviluppo di nanotecnologie Orientate alla Rigenerazione e
   Ricostruzione tissutale, Implantologia e Sensoristica in Odontoiatria"
   oculistica (SORRISO)", Grant/Award Number: pdt1-000410; Project " Studio
   di fattibilita per la progettazione di sistemi di rilascio
   nanoparticellari a base di idrossidi doppi lamellari (layered double
   hyroxide-LDH) in grado di veicolare, in modo controllato e prolungato
   nel tempo, molecole biologicamente attive tipo Ca e/o F", Grant/Award
   Number: Prot. N. 0000836/2018; PON I&C 2014-2020 FESR progetto
   "Micro/nanoformulati innovativi per la valorizzazione di molecole
   bioattive, utili per la salute e il benessere delle popolazione,
   ottenute da prodotti di scarto della filiera ittica (FORTUNA)",
   Grant/Award Number: F/050347/03IX32
CR Abe R, 2011, EUR J VASC ENDOVASC, V41, P814, DOI 10.1016/j.ejvs.2010.12.021
   Abe-Higuchi N, 2016, BIOL PSYCHIAT, V80, P815, DOI 10.1016/j.biopsych.2016.01.009
   Abete I, 2011, NUTR METAB CARDIOVAS, V21, pB1, DOI 10.1016/j.numecd.2011.05.001
   Alberti KGMM, 1998, DIABETIC MED, V15, P535, DOI 10.1002/(SICI)1096-9136(199807)15:7<535::AID-DIA670>3.0.CO;2-Q
   Albiero M, 2015, METAB SYNDR RELAT D, V13, P161, DOI 10.1089/met.2015.0005
   Albracht-Schulte K, 2018, J NUTR BIOCHEM, V58, P1, DOI 10.1016/j.jnutbio.2018.02.012
   Alcalá M, 2015, OBESITY, V23, P1598, DOI 10.1002/oby.21135
   Alirezaei M., 2014, Comparative Clinical Pathology, V23, P1359, DOI 10.1007/s00580-013-1791-8
   Allard JS, 2009, MOL CELL ENDOCRINOL, V299, P58, DOI 10.1016/j.mce.2008.10.018
   Amiot MJ, 2016, OBES REV, V17, P573, DOI 10.1111/obr.12409
   Ando K, 2009, FREE RADICAL BIO MED, V47, P213, DOI 10.1016/j.freeradbiomed.2009.04.030
   [Anonymous], 2015, The Mediterranean Diet: An Evidence-Based Approach, DOI DOI 10.1016/B978-0-12-407849-9.00029-4
   Babio N, 2014, CAN MED ASSOC J, V186, pE649, DOI 10.1503/cmaj.140764
   Babio N, 2009, PUBLIC HEALTH NUTR, V12, P1607, DOI 10.1017/S1368980009990449
   Balkau B, 1999, DIABETIC MED, V16, P442
   Barone D, 2018, J CELL PHYSIOL, V233, P1266, DOI 10.1002/jcp.25995
   Bassoli BK, 2008, CELL BIOCHEM FUNCT, V26, P320, DOI 10.1002/cbf.1444
   Basu A, 2010, J NUTR, V140, P1582, DOI 10.3945/jn.110.124701
   Baur JA, 2006, NATURE, V444, P337, DOI 10.1038/nature05354
   Bayram B, 2012, REJUV RES, V15, P71, DOI 10.1089/rej.2011.1245
   Bays Harold E, 2008, Expert Rev Cardiovasc Ther, V6, P343, DOI 10.1586/14779072.6.3.343
   Blüher M, 2013, BEST PRACT RES CL EN, V27, P163, DOI 10.1016/j.beem.2013.02.005
   Boden G, 2002, EUR J CLIN INVEST, V32, P14, DOI 10.1046/j.1365-2362.32.s3.3.x
   Camargo A, 2010, BMC GENOMICS, V11, DOI 10.1186/1471-2164-11-253
   Cao K, 2014, FREE RADICAL BIO MED, V67, P396, DOI 10.1016/j.freeradbiomed.2013.11.029
   Carluccio M.A., 2015, MEDITERRANEAN DIET, P291, DOI [10.1016/B978-0-12-407849-9.00027-0, DOI 10.1016/B978-0-12-407849-9.00027-0]
   Carluccio MA, 2003, ARTERIOSCL THROM VAS, V23, P622, DOI 10.1161/01.ATV.0000062884.69432.A0
   Chiva-Blanch G, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/5812401
   Chung SW, 2010, ARCH BIOCHEM BIOPHYS, V501, P79, DOI 10.1016/j.abb.2010.05.003
   Covas MI, 2006, ANN INTERN MED, V145, P333, DOI 10.7326/0003-4819-145-5-200609050-00006
   Dalle Grave R, 2010, DIABET METAB SYND OB, V3, P373, DOI 10.2147/DMSOTT.S13860
   Davinelli S, 2016, IMMUN AGEING, V13, DOI 10.1186/s12979-016-0070-3
   DeFuria J, 2009, J NUTR, V139, P1510, DOI 10.3945/jn.109.105155
   Devaraj S, 2008, FREE RADICAL BIO MED, V44, P1203, DOI 10.1016/j.freeradbiomed.2007.12.018
   Di Daniele N, 2017, ONCOTARGET, V8, P8947, DOI 10.18632/oncotarget.13553
   Di Renzo L, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/681318
   Dragan S, 2015, CURR MED CHEM, V22, P14
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   Esposito T, 2017, NUTRIENTS, V9, DOI 10.3390/nu9070783
   Fenni S, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201601083
   Fuhrman B, 2001, CURR OPIN LIPIDOL, V12, P41, DOI 10.1097/00041433-200102000-00008
   Ge JF, 2016, FRONT ENDOCRINOL, V7, DOI 10.3389/fendo.2016.00044
   Giordano A, 2005, CELL DEATH DIFFER, V12, P603, DOI 10.1038/sj.cdd.4401636
   Godos J, 2018, MOLECULES, V23, DOI 10.3390/molecules23050999
   Grace MH, 2009, PHYTOMEDICINE, V16, P406, DOI 10.1016/j.phymed.2009.02.018
   Gregório BM, 2016, CURR PHARM DESIGN, V22, P859, DOI 10.2174/1381612822666151209152352
   Gronbæk M, 2000, ANN INTERN MED, V133, P411, DOI 10.7326/0003-4819-133-6-200009190-00008
   Grosso G, 2014, CURR PHARM DESIGN, V20, P5039, DOI 10.2174/1381612819666131206112144
   Grosso G, 2014, J EPIDEMIOL, V24, P327, DOI 10.2188/jea.JE20130166
   Guasch-Ferré M, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/6723931
   Hadley CW, 2003, J NUTR, V133, P727, DOI 10.1093/jn/133.3.727
   Hao JJ, 2010, J NUTR BIOCHEM, V21, P634, DOI 10.1016/j.jnutbio.2009.03.012
   Harper Charles R, 2003, Prev Cardiol, V6, P136, DOI 10.1111/j.1520-037X.2003.1332.x
   Hebert AS, 2013, MOL CELL, V49, P186, DOI 10.1016/j.molcel.2012.10.024
   Hesselink MKC, 2016, NAT REV ENDOCRINOL, V12, P633, DOI 10.1038/nrendo.2016.104
   Hirabara SM, 2007, J CELL PHYSIOL, V210, P7, DOI 10.1002/jcp.20811
   Hitomi H, 2007, CURR OPIN CARDIOL, V22, P311, DOI 10.1097/HCO.0b013e3281532b53
   Hotamisligil GS, 2008, NAT REV IMMUNOL, V8, P923, DOI 10.1038/nri2449
   Hsu CL, 2009, J AGR FOOD CHEM, V57, P425, DOI 10.1021/jf802715t
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   León-Pedroza JI, 2015, CIR CIR, V83, P543, DOI 10.1016/j.circir.2015.05.041
   Johnson SA, 2015, J ACAD NUTR DIET, V115, P369, DOI 10.1016/j.jand.2014.11.001
   Juhan-Vague I, 2003, J THROMB HAEMOST, V1, P2322, DOI 10.1046/j.1538-7836.2003.00458.x
   Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213
   Kim SR, 2014, ARCH PHARM RES, V37, P539, DOI 10.1007/s12272-013-0211-6
   Klein S, 2007, DIABETES CARE, V30, P1647, DOI 10.2337/dc07-9921
   Konstantinidou V, 2010, FASEB J, V24, P2546, DOI 10.1096/fj.09-148452
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178, DOI 10.4088/JCP.v69n0202
   Kuda O, 2009, DIABETOLOGIA, V52, P941, DOI 10.1007/s00125-009-1305-z
   Kuwabara A, 2014, J NUTR SCI VITAMINOL, V60, P239, DOI 10.3177/jnsv.60.239
   Kwon EY, 2015, DIABETES, V64, P1658, DOI 10.2337/db14-0631
   Lagouge M, 2006, CELL, V127, P1109, DOI 10.1016/j.cell.2006.11.013
   Li XL, 2013, ACTA BIOCH BIOPH SIN, V45, P51, DOI 10.1093/abbs/gms108
   Lim S, 2014, REV ENDOCR METAB DIS, V15, P329, DOI 10.1007/s11154-014-9298-4
   Liu Ling, 2008, Endocrine Metabolic & Immune Disorders-Drug Targets, V8, P89, DOI 10.2174/187153008784534385
   Lombard DB, 2007, MOL CELL BIOL, V27, P8807, DOI 10.1128/MCB.01636-07
   López-Miranda J, 2010, NUTR METAB CARDIOVAS, V20, P284, DOI 10.1016/j.numecd.2009.12.007
   Mabalirajan Ulaganathan, 2013, J Allergy (Cairo), V2013, P340476, DOI 10.1155/2013/340476
   Maes Michael, 2012, Inflammopharmacology, V20, P127, DOI 10.1007/s10787-011-0111-7
   Manach C, 2004, AM J CLIN NUTR, V79, P727, DOI 10.1093/ajcn/79.5.727
   Manjunath C N, 2013, Indian J Endocrinol Metab, V17, P969, DOI 10.4103/2230-8210.122600
   Martínez-González MA, 2013, REV ENDOCR METAB DIS, V14, P265, DOI 10.1007/s11154-013-9264-6
   Medina-Remón A, 2017, BRIT J CLIN PHARMACO, V83, P114, DOI 10.1111/bcp.12986
   Medina-Remón A, 2013, MINI-REV MED CHEM, V13, P1137, DOI 10.2174/1389557511313080002
   Méndez-del Villar M, 2014, METAB SYNDR RELAT D, V12, P497, DOI 10.1089/met.2014.0082
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Monteiro R, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/289645
   Montserrat-de la Paz S, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600824
   Mora-Cubillos X, 2015, MOL NUTR FOOD RES, V59, P2480, DOI 10.1002/mnfr.201500549
   Mucerino S, 2017, SCI REP-UK, V7, DOI 10.1038/srep41824
   Muniyappa R, 2013, REV ENDOCR METAB DIS, V14, P5, DOI 10.1007/s11154-012-9229-1
   Ndiaye M, 2004, BRIT J PHARMACOL, V142, P1131, DOI 10.1038/sj.bjp.0705774
   Ng F, 2013, J CELL PHYSIOL, V228, P2262, DOI 10.1002/jcp.24399
   Nolan Paul B, 2017, Prev Med Rep, V7, P211, DOI 10.1016/j.pmedr.2017.07.004
   Oak MH, 2003, ARTERIOSCL THROM VAS, V23, P1001, DOI 10.1161/01.ATV.0000070101.70534.38
   Ong KW, 2013, BIOCHEM PHARMACOL, V85, P1341, DOI 10.1016/j.bcp.2013.02.008
   Opie LH, 2007, EUR HEART J, V28, P1683, DOI 10.1093/eurheartj/ehm149
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Panagiotakos DB, 2004, AM HEART J, V147, P106, DOI 10.1016/S0002-8703(03)00442-3
   Panche AN, 2016, J NUTR SCI, V5, DOI 10.1017/jns.2016.41
   Pandey KB, 2009, OXID MED CELL LONGEV, V2, P270, DOI 10.4161/oxim.2.5.9498
   Papoutsi Z, 2008, BRIT J NUTR, V99, P715, DOI 10.1017/S0007114507837421
   Pérez-Martínez P, 2017, NUTR REV, V75, P307, DOI 10.1093/nutrit/nux014
   Peyrol J, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030306
   Pischon T, 2004, JAMA-J AM MED ASSOC, V291, P1730, DOI 10.1001/jama.291.14.1730
   Pougovkina O, 2014, HUM MOL GENET, V23, P3513, DOI 10.1093/hmg/ddu059
   Reboredo-Rodríguez P, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18030668
   Riccitiello F, 2018, EUR POLYM J, V99, P289, DOI 10.1016/j.eurpolymj.2017.12.035
   Rietjens SJ, 2007, AM J PHYSIOL-HEART C, V292, pH1931, DOI 10.1152/ajpheart.00755.2006
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Ros E, 2010, NUTRIENTS, V2, P652, DOI 10.3390/nu2070652
   Rumawas ME, 2009, AM J CLIN NUTR, V90, P1608, DOI 10.3945/ajcn.2009.27908
   Saibandith B, 2017, MOLECULES, V22, DOI 10.3390/molecules22071082
   Saija A, 1998, Int J Cosmet Sci, V20, P331, DOI 10.1046/j.1467-2494.1998.177057.x
   Salas-Salvadó J, 2008, ARCH INTERN MED, V168, P2449, DOI 10.1001/archinte.168.22.2449
   Sánchez-González C, 2017, CRIT REV FOOD SCI, V57, P3373, DOI 10.1080/10408398.2015.1126218
   Scapagnini G, 2012, CNS DRUGS, V26, P477, DOI 10.2165/11633190-000000000-00000
   Scoditti E, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0128218
   Servili M, 2004, J CHROMATOGR A, V1054, P113, DOI 10.1016/S0021-9673(04)01423-2
   Shamim U, 2012, J CELL PHYSIOL, V227, P1493, DOI 10.1002/jcp.22865
   Smith RL, 2018, ENDOCR REV, V39, P489, DOI 10.1210/er.2017-00211
   Soleas GJ, 2001, METHOD ENZYMOL, V335, P130
   Spencer M, 2013, DIABETES, V62, P1709, DOI 10.2337/db12-1042
   Squillaro T, 2018, J CELL PHYSIOL, V233, P3955, DOI 10.1002/jcp.26170
   Sun C, 2007, CELL METAB, V6, P307, DOI 10.1016/j.cmet.2007.08.014
   Suzuki A, 2007, AM J HYPERTENS, V20, P508, DOI 10.1016/j.amjhyper.2006.11.008
   Takeda Y, 2014, BIOCHEM BIOPH RES CO, V446, P1225, DOI 10.1016/j.bbrc.2014.03.094
   Tangvarasittichai S, 2016, INDIAN J CLIN BIOCHE, V31, P446, DOI 10.1007/s12291-016-0553-1
   Torrens-Mas M, 2018, J CELL PHYSIOL, V233, P6067, DOI 10.1002/jcp.26443
   Tortosa A, 2007, DIABETES CARE, V30, P2957, DOI 10.2337/dc07-1231
   Ukropcova B, 2007, DIABETES, V56, P720, DOI 10.2337/db06-0521
   Ungvari Z, 2010, AM J PHYSIOL-HEART C, V299, pH18, DOI 10.1152/ajpheart.00260.2010
   Valentino A, 2017, ONCOGENE, V36, P6030, DOI 10.1038/onc.2017.216
   van Dijk AE, 2009, DIABETES CARE, V32, P1023, DOI 10.2337/dc09-0207
   van Zwieten P A, 2006, Neth Heart J, V14, P301
   Vanecková I, 2014, J ENDOCRINOL, V223, pR63, DOI 10.1530/JOE-14-0368
   Villarroya J, 2013, AM J PHYSIOL-ENDOC M, V305, pE567, DOI 10.1152/ajpendo.00250.2013
   Vinson JA, 2012, FOOD FUNCT, V3, P134, DOI 10.1039/c2fo10152a
   Wallerath T, 2003, J AM COLL CARDIOL, V41, P471, DOI 10.1016/S0735-1097(02)02826-7
   Wang B, 2014, J FOOD SCI, V79, pH1823, DOI 10.1111/1750-3841.12555
   Weiss R, 2013, ANN NY ACAD SCI, V1281, P123, DOI 10.1111/nyas.12030
   Winand J, 2014, FOOD FUNCT, V5, P310, DOI 10.1039/c3fo60443h
   Wong SK, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00444
   Yu YM, 2005, J NUTR BIOCHEM, V16, P675, DOI 10.1016/j.jnutbio.2005.03.013
   Zaghini I, 2002, J BIOL CHEM, V277, P1324, DOI 10.1074/jbc.M106375200
   Zhang XM, 2009, N-S ARCH PHARMACOL, V379, P581, DOI 10.1007/s00210-009-0399-7
   Zheng A, 2015, J NUTR BIOCHEM, V26, P190, DOI 10.1016/j.jnutbio.2014.10.006
   Zhu XY, 2017, NUTR METAB, V14, DOI 10.1186/s12986-017-0217-z
   Zimmet P, 2005, J ATHEROSCLER THROMB, V12, P295, DOI 10.5551/jat.12.295
NR 149
TC 136
Z9 142
U1 1
U2 128
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD MAY
PY 2019
VL 234
IS 5
BP 5807
EP 5826
DI 10.1002/jcp.27506
PG 20
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA HK7AQ
UT WOS:000458138600041
PM 30317573
DA 2025-06-11
ER

PT J
AU Rayssiguier, Y
   Gueux, E
   Nowacki, W
   Rock, E
   Mazur, A
AF Rayssiguier, Y.
   Gueux, E.
   Nowacki, W.
   Rock, E.
   Mazur, A.
TI High fructose consumption combined with low dietary magnesium intake may
   increase the incidence of the metabolic syndrome by inducing
   inflammation
SO MAGNESIUM RESEARCH
LA English
DT Article
DE magnesium; fructose; metabolic syndrome; inflammation
ID VASCULAR SMOOTH-MUSCLE; C-REACTIVE PROTEIN; HIGH-SUCROSE DIET;
   INSULIN-RESISTANCE; LIPID-PEROXIDATION; GENE-EXPRESSION; DEFICIENT RATS;
   MG-DEFICIENCY; SUBSTANCE-P; ACTIVATION
AB The metabolic syndrome is a cluster of common pathologies: abdominal obesity linked to an excess of visceral fat, insulin resistance, dyslipidemia and hypertension. This syndrome is occurring at epidemic rates, with dramatic consequences for human health worldwide, and appears to have emerged largely from changes in our diet and reduced physical activity. An important but not well-appreciated dietary change has been the substantial increase in fructose intake, which appears to be an important causative factor in the metabolic syndrome. There is also experimental and clinical evidence that the amount of magnesium in the western diet is insufficient to meet individual needs and that magnesium deficiency may contribute to insulin resistance. In recent years, several studies have been published that implicate subclinical chronic inflammation as an important pathogenic factor in the development of metabolic syndrome. Pro-inflammatory molecules produced by adipose tissue have been implicated in the development of insulin resistance. The present review will discuss experimental evidence showing that the metabolic syndrome, high fructose intake and low magnesium diet may all be linked to the inflammatory response. In many ways, fructose-fed rats display the changes observed in the metabolic syndrome and recent studies indicate that high-fructose feeding is associated with NADPH oxidase and renin-angiotensin activation. The production of reactive oxygen species results in the initiation and development of insulin resistance, hyperlipemia and high blood pressure in this model. In this rat model, a few days of experimental magnesium deficiency produces a clinical inflammatory syndrome characterized by leukocyte and macrophage activation, release of inflammatory cytokines, appearance of the acute phase proteins and excessive production of free radicals. Because magnesium acts as a natural calcium antagonist, the molecular basis for the inflammatory response is probably the result of a modulation of the intracellular calcium concentration. Potential mechanisms include the priming of phagocytic cells, the opening of calcium channels, activation of N-methyl-D-aspartate (NMDA) receptors, the activation of nuclear factor-kappaB (NFkB) and activation of the renin-angiotensin system. Since magnesium deficiency has a pro-inflammatory effect, the expected consequence would be an increased risk of developing insulin resistance when magnesium deficiency is combined with a high-fructose diet. Accordingly, magnesium deficiency combined with a high-fructose diet induces insulin resistance, hypertension, dyslipidemia, endothelial activation and prothrombic changes in combination with the upregulation of markers of inflammation and oxidative stress.
C1 INRA, Unite Nutr Humaine, F-63122 St Genes Champanelle, France.
   Fac Vet, PL-50375 Wroclaw, Poland.
C3 INRAE
RP Rayssiguier, Y (corresponding author), INRA, Unite Nutr Humaine, F-63122 St Genes Champanelle, France.
EM yrayssig@clermont.mra.fr
RI Mazur, Andre/AAG-9751-2020
OI Mazur, Andre/0000-0002-1067-5066; Nowacki, Wojciech/0000-0002-8304-0686
CR Altura BM, 2003, NEUROSCI LETT, V341, P189, DOI 10.1016/S0304-3940(03)00134-4
   Armutcu F, 2005, CLIN BIOCHEM, V38, P540, DOI 10.1016/j.clinbiochem.2005.01.013
   AUGUSTI Y, 1973, CR SOC BIOL, V167, P1804
   Barbagallo Mario, 2003, Molecular Aspects of Medicine, V24, P39, DOI 10.1016/S0098-2997(02)00090-0
   Basciano Heather, 2005, Nutr Metab (Lond), V2, P5, DOI 10.1186/1743-7075-2-5
   BERNARDINI D, 2005, FRONT BIOSCI, P10
   Bukoski RD, 2002, J HYPERTENS, V20, P2141, DOI 10.1097/00004872-200211000-00009
   Busserolles J, 2003, J NUTR, V133, P1903, DOI 10.1093/jn/133.6.1903
   Busserolles J, 2002, LIFE SCI, V71, P1303, DOI 10.1016/S0024-3205(02)01846-5
   Busserolles J, 2002, BRIT J NUTR, V87, P337, DOI 10.1079/BJNBJN2002524
   Busserolles J, 2002, EXP BIOL MED, V227, P837, DOI 10.1177/153537020222700918
   Busserolles J, 2003, MAGNESIUM RES, V16, P7
   Bussiere F., 2001, Advances in magnesium research: nutrition and health, P313
   Bussiere FI, 2002, MAGNESIUM RES, V15, P37
   Bussière FI, 2002, EUR J NUTR, V41, P197, DOI 10.1007/s00394-002-0376-0
   Bussière FI, 2002, BRIT J NUTR, V87, P107, DOI 10.1079/BJN2001498
   Bussiere Laurence, 1995, Magnesium Research, V8, P151
   Chaudhary DP, 2004, MAGNESIUM RES, V17, P293
   Dandona P, 2004, TRENDS IMMUNOL, V25, P4, DOI 10.1016/j.it.2003.10.013
   Delbosc S, 2005, ATHEROSCLEROSIS, V179, P43, DOI 10.1016/j.atherosclerosis.2004.10.018
   Dubray C, 1997, NEUROREPORT, V8, P1383, DOI 10.1097/00001756-199704140-00013
   Fantuzzi G, 2005, J ALLERGY CLIN IMMUN, V115, P911, DOI 10.1016/j.jaci.2005.02.023
   Guerrero-Romero F, 2002, ACTA DIABETOL, V39, P209, DOI 10.1007/s005920200036
   GUERREROROMERO F, 2006, IN PRESS METAB RES R
   GUEUX E, 1984, J NUTR, V114, P1479, DOI 10.1093/jn/114.8.1479
   GUEUX E, 1991, J NUTR, V121, P1222, DOI 10.1093/jn/121.8.1222
   Gueux E, 1995, BRIT J NUTR, V74, P849, DOI 10.1079/BJN19950011
   He K, 2006, CIRCULATION, V113, P1675, DOI 10.1161/CIRCULATIONAHA.105.588327
   Huerta MG, 2005, DIABETES CARE, V28, P1175, DOI 10.2337/diacare.28.5.1175
   Kelley Glen L, 2005, Nutr Metab (Lond), V2, P18, DOI 10.1186/1743-7075-2-18
   Khovidhunkit W, 2000, J INFECT DIS, V181, pS462, DOI 10.1086/315611
   King DE, 2005, J AM COLL NUTR, V24, P166, DOI 10.1080/07315724.2005.10719461
   Lopez-Ridaura R, 2004, DIABETES CARE, V27, P134, DOI 10.2337/diacare.27.1.134
   Maier JAM, 2004, BBA-MOL BASIS DIS, V1689, P13, DOI 10.1016/j.bbadis.2004.01.002
   Maier Jeanette A. M., 2003, Molecular Aspects of Medicine, V24, P137
   Malpuech-Brugère C, 2000, BBA-MOL BASIS DIS, V1501, P91, DOI 10.1016/S0925-4439(00)00018-1
   Malpuech-Brugère C, 1998, LIFE SCI, V63, P1815, DOI 10.1016/S0024-3205(98)00455-X
   MAZUR A, 2006, IN PRESS ARCH BIOCH
   Nakagawa T, 2006, AM J PHYSIOL-RENAL, V290, pF625, DOI 10.1152/ajprenal.00140.2005
   NASSIR F, 1995, BBA-LIPID LIPID MET, V1257, P125, DOI 10.1016/0005-2760(95)00065-K
   Nasulewicz A, 2004, MAGNESIUM RES, V17, P259
   Nieuwdorp M, 2005, CURR OPIN PHARMACOL, V5, P155, DOI 10.1016/j.coph.2004.10.003
   O'Connor TM, 2004, J CELL PHYSIOL, V201, P167, DOI 10.1002/jcp.20061
   RAYSSIGUIER Y, 1993, J AM COLL NUTR, V12, P133
   RAYSSIGUIER Y, 1981, J NUTR, V111, P1876, DOI 10.1093/jn/111.11.1876
   RAYSSIGUIER Y, 1991, LIPIDS, V26, P182, DOI 10.1007/BF02543968
   Rayssiguier Y., 2001, Advances in magnesium research: nutrition and health, P277
   Rayssiguier Y, 1992, Magnes Res, V5, P139
   RAYSSIGUIER Y, 1986, J AM COLL NUTR, V5, P507
   RAYSSIGUIER Y, 2005, CLIN CALCIUM, V15, P101
   Rodríguez-Hernández H, 2005, ARCH MED RES, V36, P362, DOI 10.1016/j.arcmed.2005.03.008
   Rodríguez-Morán M, 2004, MAGNESIUM RES, V17, P189
   Rudin Eric, 2005, Immun Ageing, V2, P1, DOI 10.1186/1742-4933-2-1
   Sabbagh F, 2005, MAGNESIUM RES, V18, P225
   Sabbagh F, 2005, MAGNESIUM RES, V18, P235
   Sapna S, 2006, AM J PHYSIOL-HEART C, V291, pH436, DOI 10.1152/ajpheart.01185.2005
   Shechter M, 1999, AM J CARDIOL, V84, P152, DOI 10.1016/S0002-9149(99)00225-8
   Shinozaki K, 2004, HYPERTENSION, V43, P255, DOI 10.1161/01.HYP.0000111136.86976.26
   Sjöholm Å, 2006, DIABETES-METAB RES, V22, P4, DOI 10.1002/dmrr.568
   Sjöholm Å, 2005, LANCET, V365, P610, DOI 10.1016/S0140-6736(05)70804-7
   Song YQ, 2005, DIABETES CARE, V28, P1438, DOI 10.2337/diacare.28.6.1438
   Takaya J, 2004, MAGNESIUM RES, V17, P126
   TEJEROTALDO I, 2004, JPET, V311, P1
   Touyz R. M., 2003, Molecular Aspects of Medicine, V24, P107, DOI 10.1016/S0098-2997(02)00094-8
   Ueshima K, 2005, MAGNESIUM RES, V18, P275
   Weglicki WB, 1996, CARDIOVASC RES, V31, P677, DOI 10.1016/0008-6363(95)00196-4
NR 66
TC 87
Z9 100
U1 0
U2 13
PU JOHN LIBBEY EUROTEXT LTD
PI MONTROUGE
PA 127 AVE DE LA REPUBLIQUE, 92120 MONTROUGE, FRANCE
SN 0953-1424
EI 1952-4021
J9 MAGNESIUM RES
JI Magnes. Res.
PD DEC
PY 2006
VL 19
IS 4
BP 237
EP 243
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 139HI
UT WOS:000244422500002
PM 17402291
DA 2025-06-11
ER

PT J
AU Ma, WQ
   Sun, XJ
   Zhu, Y
   Liu, NF
AF Ma, Wen-Qi
   Sun, Xue-Jiao
   Zhu, Yi
   Liu, Nai-Feng
TI Metformin attenuates hyperlipidaemia-associated vascular calcification
   through anti-ferroptotic effects
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Metformin; Vascular calcification; Ferroptosis; Periostin; p53
ID SMOOTH-MUSCLE-CELLS; TUMOR-SUPPRESSOR; PERIOSTIN; P53; MECHANISMS;
   ATHEROSCLEROSIS; DIFFERENTIATION; INFLAMMATION; INHIBITION; EXPRESSION
AB Ferroptosis is a form of regulated cell death that involves metabolic dysfunction resulting from iron-dependent excessive lipid peroxidation. Elevated plasma levels of free fatty acids are tightly associated with cardiometabolic risk factors in patients with obesity, diabetes mellitus, and metabolic syndrome. Metformin (Met) is an antidiabetic drug with beneficial cardiovascular disease effects. The aim of this study was to determine the effects of Met on ferroptosis induced by lipid overload and the effects of these changes on vascular smooth muscle cells (VSMCs) calcification. We developed a hyperlipidaemia-related vascular calcification in vivo model with rats fed a high-fat diet combined with vitamin D3 plus nicotine, and palmitic acid (PA), the most abundant long-chain saturated fatty acid in plasma, was used to induce lipid overload and develop an oxidative stress-related calcification model in vitro. The results showed that Met inhibits hyperlipidaemia-associated calcium deposition in the rat aortic tissue. In vitro, treatment of VSMCs with PA stimulates ferroptosis concomitant with increased calcium deposition in VSMCs, while pretreatment with Met attenuates these effects. Furthermore, PA also promotes the protein expression of the extracellular matrix protein periostin (POSTN) and its secretion into the extracellular environment. More importantly, upregulation of POSTN increased the sensitivity of cells to ferroptosis. Mechanistically, upregulation of POSTN suppresses SLC7A11 expression through the inhibition of p53 in VSMCs, which contributes to a decrease in glutathione synthesis and therefore triggers ferroptosis. Interestingly, over expression of p53 attenuates the inhibitory effect of POSTN on SLC7A11 expression, accompanied by increased Gpx4 expression. Furthermore, p53 knockdown suppresses Met-mediated anti-ferroptosis effects in PA-treated VSMCs, which may be related to the downregulation of SLC7A11 expression. In addition, supplementation of VSMCs with Met enhances the antioxidative capacity of VSMCs through Nrf2 signalling activation. Collectively, targeting POSTN in VSMCs may provide a new strategy for vascular calcification prevention or treatment.
C1 [Ma, Wen-Qi; Sun, Xue-Jiao; Zhu, Yi; Liu, Nai-Feng] Southeast Univ 87 Dingjiaqiao, Zhongda Hosp, Sch Med, Dept Cardiol, Nanjing 210009, Peoples R China.
C3 Southeast University - China
RP Liu, NF (corresponding author), Southeast Univ 87 Dingjiaqiao, Zhongda Hosp, Sch Med, Dept Cardiol, Nanjing 210009, Peoples R China.
EM liunf@seu.edu.cn
RI Liu, Nai-feng/AAM-7836-2020
OI Ma, Wen-Qi/0000-0002-0287-8496
FU National Natural Science Foundation of China [81970381]; Fundamental
   Research Funds for the Central Universities; Postgraduate Research &
   Practice Innovation Program of Jiangsu Province [KYCX20_0148,
   KYCX18_0170]
FX This work was supported by National Natural Science Foundation of China
   (81970381) , the Fundamental Research Funds for the Central
   Universities, and the Postgraduate Research & Practice Innovation
   Program of Jiangsu Province (KYCX20_0148, KYCX18_0170) .
CR Abdalkader M, 2018, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00466
   Bagnato C, 2007, MOL CELL PROTEOMICS, V6, P1088, DOI 10.1074/mcp.M600259-MCP200
   Brodeur MR, 2013, J VASC RES, V50, P430, DOI 10.1159/000354235
   Cao XR, 2013, ENDOCRINOLOGY, V154, P3680, DOI 10.1210/en.2013-1002
   Demer LL, 2014, ARTERIOSCL THROM VAS, V34, P715, DOI 10.1161/ATVBAHA.113.302070
   Dixon SJ, 2012, CELL, V149, P1060, DOI 10.1016/j.cell.2012.03.042
   Dodson M, 2019, REDOX BIOL, V23, DOI 10.1016/j.redox.2019.101107
   Durham AL, 2018, CARDIOVASC RES, V114, P590, DOI 10.1093/cvr/cvy010
   Evrard S, 2015, CLIN CHIM ACTA, V438, P401, DOI 10.1016/j.cca.2014.08.034
   Gao MH, 2016, CELL RES, V26, P1021, DOI 10.1038/cr.2016.95
   Ghosh S, 2020, PHARMACOL RES, V158, DOI 10.1016/j.phrs.2020.104861
   Hakuno D, 2010, J CLIN INVEST, V120, P2292, DOI 10.1172/JCI40973
   Idolazzi L, 2017, EUR J INTERN MED, V38, P12, DOI 10.1016/j.ejim.2016.11.015
   Izuhara K, 2017, CELL MOL LIFE SCI, V74, P4293, DOI 10.1007/s00018-017-2648-0
   Jiang L, 2015, NATURE, V520, P57, DOI 10.1038/nature14344
   Johnson RC, 2006, CIRC RES, V99, P1044, DOI 10.1161/01.RES.0000249379.55535.21
   Kageyama A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0068197
   Kang R, 2019, FREE RADICAL BIO MED, V133, P162, DOI 10.1016/j.freeradbiomed.2018.05.074
   Kormann R, 2020, J AM SOC NEPHROL, V31, P85, DOI 10.1681/ASN.2019020113
   Lambertucci RH, 2008, J CELL PHYSIOL, V216, P796, DOI 10.1002/jcp.21463
   Landry NM, 2018, BASIC RES CARDIOL, V113, DOI 10.1007/s00395-017-0659-5
   Lee H, 2020, NAT CELL BIOL, V22, DOI 10.1038/s41556-020-0461-8
   Lee J, 2020, BIOCHEM BIOPH RES CO, V530, P374, DOI 10.1016/j.bbrc.2020.07.136
   Leopold JA, 2015, TRENDS CARDIOVAS MED, V25, P267, DOI 10.1016/j.tcm.2014.10.021
   Li GH, 2010, ATHEROSCLEROSIS, V208, P358, DOI 10.1016/j.atherosclerosis.2009.07.046
   Li KL, 2012, CARDIOVASC J AFR, V23, pE1, DOI 10.5830/CVJA-2011-069
   Liu LP, 2018, ARTERIOSCL THROM VAS, V38, P2382, DOI 10.1161/ATVBAHA.118.311546
   Lu Y, 2014, J CLIN INVEST, V124, P3501, DOI 10.1172/JCI74438
   Lv HJ, 2014, CELL CYCLE, V13, P2962, DOI 10.4161/15384101.2014.947203
   Ma WQ, 2019, MOL CELL ENDOCRINOL, V479, P39, DOI 10.1016/j.mce.2018.08.012
   Marín-Aguilar F, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18020288
   Masaldan S, 2018, REDOX BIOL, V14, P100, DOI 10.1016/j.redox.2017.08.015
   Nakano-Kurimoto R, 2009, AM J PHYSIOL-HEART C, V297, pH1673, DOI 10.1152/ajpheart.00455.2009
   Neven E, 2018, KIDNEY INT, V94, P102, DOI 10.1016/j.kint.2018.01.027
   Nyane NA, 2017, EUR J PHARMACOL, V803, P103, DOI 10.1016/j.ejphar.2017.03.042
   Otsuka F, 2014, ARTERIOSCL THROM VAS, V34, P724, DOI 10.1161/ATVBAHA.113.302642
   Prakoura N, 2017, J AM SOC NEPHROL, V28, P1475, DOI 10.1681/ASN.2016070709
   Proudfoot D, 2002, CIRCULATION, V106, P3044, DOI 10.1161/01.CIR.0000041429.83465.41
   Qi J, 2020, AM J PATHOL, V190, P68, DOI 10.1016/j.ajpath.2019.09.011
   Rashdan NA, 2020, J BONE MINER RES, V35, P357, DOI 10.1002/jbmr.3888
   Sage AP, 2010, NAT REV CARDIOL, V7, P528, DOI 10.1038/nrcardio.2010.115
   Samblas M, 2019, J PHYSIOL BIOCHEM, V75, P341, DOI 10.1007/s13105-019-00685-5
   Schinzari F, 2019, AM J PHYSIOL-ENDOC M, V317, pE658, DOI 10.1152/ajpendo.00204.2019
   Schwanekamp JA, 2016, ARTERIOSCL THROM VAS, V36, P60, DOI 10.1161/ATVBAHA.115.306397
   Song XH, 2020, FRONT NEUROSCI-SWITZ, V14, DOI 10.3389/fnins.2020.00267
   Song XX, 2018, CURR BIOL, V28, P2388, DOI 10.1016/j.cub.2018.05.094
   Tarangelo A, 2018, CELL REP, V22, P569, DOI 10.1016/j.celrep.2017.12.077
   Vinchi F, 2020, EUR HEART J, V41, P2681, DOI 10.1093/eurheartj/ehz112
   Wang SJ, 2016, CELL REP, V17, P366, DOI 10.1016/j.celrep.2016.09.022
   Wang ZQ, 2012, ATHEROSCLEROSIS, V221, P387, DOI 10.1016/j.atherosclerosis.2012.01.019
   Wu D, 2014, INT J MOL MED, V34, P1706, DOI 10.3892/ijmm.2014.1942
   Wu H, 2016, MOL MED REP, V14, P776, DOI 10.3892/mmr.2016.5308
   Wu ZQ, 2018, CONNECT TISSUE RES, V59, P108, DOI 10.1080/03008207.2017.1306060
   Xie Y, 2016, CELL DEATH DIFFER, V23, P369, DOI 10.1038/cdd.2015.158
   Xie YC, 2017, CELL REP, V20, P1692, DOI 10.1016/j.celrep.2017.07.055
   Yao L, 2020, MOL CELL PROBE, V53, DOI 10.1016/j.mcp.2020.101596
   Ye D, 2019, J CLIN LAB ANAL, V33, DOI 10.1002/jcla.22622
   Zhang L, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/1675613
   Zhang XY, 2016, VASC PHARMACOL, V81, P83, DOI 10.1016/j.vph.2016.01.002
   Zhang ZL, 2020, REDOX BIOL, V36, DOI 10.1016/j.redox.2020.101619
NR 60
TC 112
Z9 121
U1 2
U2 82
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD MAR
PY 2021
VL 165
BP 229
EP 242
DI 10.1016/j.freeradbiomed.2021.01.033
EA FEB 2021
PG 14
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA RB2YT
UT WOS:000631981900003
PM 33513420
DA 2025-06-11
ER

PT J
AU Lin, Z
   Gonçalves, CMV
   Dai, L
   Lu, HM
   Huang, JH
   Ji, HC
   Wang, DS
   Yi, LZ
   Liang, YZ
AF Lin, Zhang
   Vicente Goncalves, Carlos M.
   Dai, Ling
   Lu, Hong-mei
   Huang, Jian-hua
   Ji, Hongchao
   Wang, Dong-sheng
   Yi, Lun-zhao
   Liang, Yi-zeng
TI Exploring metabolic syndrome serum profiling based on gas chromatography
   mass spectrometry and random forest models
SO ANALYTICA CHIMICA ACTA
LA English
DT Article
DE Metabolic syndrome; Serum profiling; GC-MS; Random forest; Biomarker
ID C-REACTIVE PROTEIN; BLOOD-PRESSURE; IDENTIFICATION; MYOINOSITOL;
   COMPONENTS; RESISTANCE; LIPOLYSIS; SELECTION; OBESITY; STRESS
AB Metabolic syndrome (MetS) is a constellation of the most dangerous heart attack risk factors: diabetes and raised fasting plasma glucose, abdominal obesity, high cholesterol and high blood pressure. Analysis and representation of the variances of metabolic profiles is urgently needed for early diagnosis and treatment of MetS. In current study, we proposed a metabolomics approach for analyzing MetS based on GC-MS profiling and random forest models. The serum samples from healthy controls and MetS patients were characterized by GC-MS. Then, random forest (RF) models were used to visually discriminate the serum changes in MetS based on these GC-MS profiles. Simultaneously, some informative metabolites or potential biomarkers were successfully discovered by means of variable importance ranking in random forest models. The metabolites such as 2-hydroxybutyric acid, inositol and D-glucose, were defined as potential biomarkers to diagnose the MetS. These results obtained by proposed method showed that the combining GC-MS profiling with random forest models was a useful approach to analyze metabolites variances and further screen the potential biomarkers for MetS diagnosis. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Lin, Zhang; Vicente Goncalves, Carlos M.; Dai, Ling; Lu, Hong-mei; Huang, Jian-hua; Ji, Hongchao; Yi, Lun-zhao; Liang, Yi-zeng] Cent South Univ, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China.
   [Vicente Goncalves, Carlos M.] Univ Cadiz, Fac Ciencias, Dept Quim Analit, Cadiz, Spain.
   [Wang, Dong-sheng] Cent South Univ, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China.
C3 Central South University; Universidad de Cadiz; Central South University
RP Huang, JH (corresponding author), Cent South Univ, Res Ctr Modernizat Tradit Chinese Med Chem & Chem, Changsha 410083, Hunan, Peoples R China.
EM hongmeilu@csu.edu.cn; huangjh85@gmail.com
RI yi, lunzhao/AAS-3256-2021; DAI, LING/KXR-4417-2024; Gonçalves,
   Carlos/N-1816-2015; Huang, Jianhua/C-3929-2011; Ji, Hongchao/I-3676-2019
OI Ji, Hongchao/0000-0002-7364-0741; Liang, Yizeng/0000-0001-8692-3030
FU National Nature Foundation Committee of PR China [21175157, 21105129,
   21375151]; China Hunan Provincial Science and Technology Department
   [2012FJ4139]; Central South University for Special Support of the Basic
   Scientific Research Project [2010QZZD007]; China Postdoctoral Science
   Foundation [201104511]
FX This work is financially supported by the National Nature Foundation
   Committee of PR China (No. 21175157, No. 21105129, and No. 21375151),
   China Hunan Provincial Science and Technology Department (No.
   2012FJ4139), Central South University for Special Support of the Basic
   Scientific Research Project (No. 2010QZZD007), China Postdoctoral
   Science Foundation (No. 201104511).
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   [Anonymous], 2001, Guidance for industry: bioanalytical method validation, P1
   [Anonymous], J ANAL SCI TECHNOLOG
   Atherton HJ, 2006, PHYSIOL GENOMICS, V27, P178, DOI 10.1152/physiolgenomics.00060.2006
   Breiman L., 2001, Machine Learning, V45, P5, DOI 10.1023/A:1010933404324
   Bryan K, 2008, BMC BIOINFORMATICS, V9, DOI 10.1186/1471-2105-9-470
   Castro G, 2013, FEBS OPEN BIO, V3, P443, DOI 10.1016/j.fob.2013.09.002
   Chakrabarti P, 2011, CURR DIABETES REV, V7, P270, DOI 10.2174/157339911796397866
   Chen Z., 2013, BMC MED GENOMICS S1, V6
   Croze ML, 2013, BIOCHIMIE, V95, P1811, DOI 10.1016/j.biochi.2013.05.011
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Duncan RE, 2007, ANNU REV NUTR, V27, P79, DOI 10.1146/annurev.nutr.27.061406.093734
   Dunn WB, 2011, NAT PROTOC, V6, P1060, DOI 10.1038/nprot.2011.335
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Gall WE, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010883
   Gil JS, 2013, CLINICS, V68, P1495, DOI 10.6061/clinics/2013(12)04
   Goudarzi N, 2012, ANAL METHODS-UK, V4, P3733, DOI 10.1039/c2ay25484k
   Huang CF, 2013, DIABETES CARE, V36, P1729, DOI 10.2337/dc12-1067
   Huang JH, 2013, ANAL METHODS-UK, V5, P4883, DOI 10.1039/c3ay40379c
   Hummel J, 2010, METABOLOMICS, V6, P322, DOI 10.1007/s11306-010-0198-7
   Hwang JH, 2013, J KOREAN MED SCI, V28, P1768, DOI 10.3346/jkms.2013.28.12.1768
   Kalhan SC, 2011, METABOLISM, V60, P404, DOI 10.1016/j.metabol.2010.03.006
   Kim JS, 2012, CANCER BIOL THER, V13, P1307, DOI 10.4161/cbt.21788
   Liland KH, 2011, TRAC-TREND ANAL CHEM, V30, P827, DOI 10.1016/j.trac.2011.02.007
   Lusis AJ, 2008, NAT REV GENET, V9, P819, DOI 10.1038/nrg2468
   Melka MG, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0082368
   Musani SK, 2013, DIABETES CARE, V36, P3084, DOI 10.2337/dc12-2562
   Noguchi R., 2013, MOL SYSTEMS BIOL, P9
   Palmer DS, 2007, J CHEM INF MODEL, V47, P150, DOI 10.1021/ci060164k
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   SAAD MF, 1991, NEW ENGL J MED, V324, P733, DOI 10.1056/NEJM199103143241105
   Saisho Y, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0073430
   Sangster T, 2006, ANALYST, V131, P1075, DOI 10.1039/b604498k
   Shiochi H, 2010, DIABETOLOGIA, V53, pS163
   Stern MP, 2004, DIABETES CARE, V27, P2676, DOI 10.2337/diacare.27.11.2676
   Svetnik V, 2003, J CHEM INF COMP SCI, V43, P1947, DOI 10.1021/ci034160g
   Tsimikas S, 2006, J AM COLL CARDIOL, V47, pC19, DOI 10.1016/j.jacc.2005.10.066
   Tulipani S, 2011, J PROTEOME RES, V10, P5047, DOI 10.1021/pr200514h
   Williams PJ, 2007, HYPERTENSION, V49, P84, DOI 10.1161/01.HYP.0000251301.12357.ba
   Ye YM, 2013, PATTERN RECOGN, V46, P769, DOI 10.1016/j.patcog.2012.09.005
   Zhu ZW, 2013, PLOS ONE, V8, DOI [10.1371/journal.pone.0056662, 10.1371/journal.pone.0080028]
NR 41
TC 60
Z9 60
U1 1
U2 67
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0003-2670
EI 1873-4324
J9 ANAL CHIM ACTA
JI Anal. Chim. Acta
PD MAY 27
PY 2014
VL 827
BP 22
EP 27
DI 10.1016/j.aca.2014.04.008
PG 6
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA AH2BN
UT WOS:000335925800003
PM 24832990
DA 2025-06-11
ER

PT J
AU Lanza, GA
AF Lanza, G. A.
TI Cardiac syndrome X: a critical overview and future perspectives
SO HEART
LA English
DT Review
ID NORMAL CORONARY ANGIOGRAMS; CHEST-PAIN; ANGINA-PECTORIS; ARTERY-DISEASE;
   BLOOD-FLOW; ENDOTHELIAL DYSFUNCTION; MICROVASCULAR ANGINA; VASODILATOR
   RESERVE; NERVE FUNCTION; MENTAL STRESS
AB The classic definition of cardiac syndrome X (CSX) seems inadequate both for clinical and research purposes and should be replaced with one aimed at including a sufficiently homogeneous group of patients with the common plausible pathophysiological mechanism of coronary microvascular dysfunction. More specifically, CSX should be defined as a form of stable effort angina, which, according to careful diagnostic investigation, can reasonably be attributed to abnormalities in the coronary microvascular circulation.
C1 Univ Cattolica Sacro Cuore, Ist Cardiol, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Lanza, GA (corresponding author), Univ Cattolica Sacro Cuore, Ist Cardiol, Largo A Gemelli 8, I-00168 Rome, Italy.
EM g.a.lanza@inwind.it
RI Lanza, Gaetano/AAC-2660-2019
CR BOTKER HE, 1993, LANCET, V342, P136
   Bottcher M, 1999, CIRCULATION, V99, P1795
   BRUSH JE, 1988, NEW ENGL J MED, V319, P1302, DOI 10.1056/NEJM198811173192002
   Buchthal SD, 2000, NEW ENGL J MED, V342, P829, DOI 10.1056/NEJM200003233421201
   Buffon A, 2000, AM J PHYSIOL-HEART C, V279, pH2627, DOI 10.1152/ajpheart.2000.279.6.H2627
   Bugiardini R, 2004, CIRCULATION, V109, P2518, DOI 10.1161/01.CIR.0000128208.22378.E3
   Bugiardini R, 1993, J AM COLL CARDIOL, V22, P417, DOI 10.1016/0735-1097(93)90045-3
   CAMICI PG, 1991, J AM COLL CARDIOL, V17, P1461, DOI 10.1016/0735-1097(91)90632-J
   CANNON RO, 1990, J AM COLL CARDIOL, V16, P1359, DOI 10.1016/0735-1097(90)90377-2
   CANNON RO, 1992, CIRCULATION, V85, P883, DOI 10.1161/01.CIR.85.3.883
   CANNON RO, 1983, J AM COLL CARDIOL, V1, P1359, DOI 10.1016/S0735-1097(83)80037-0
   CHAUHAN A, 1993, BRIT HEART J, V69, P516
   Cosín-Sales J, 2003, J AM COLL CARDIOL, V41, P1468, DOI 10.1016/S0735-1097(03)00243-2
   Cox ID, 1999, J AM COLL CARDIOL, V34, P455, DOI 10.1016/S0735-1097(99)00224-7
   Crea F, 2004, HEART, V90, P457, DOI 10.1136/hrt.2003.020594
   DiCarli MF, 1997, NEW ENGL J MED, V336, P1208, DOI 10.1056/NEJM199704243361703
   EGASHIRA K, 1993, NEW ENGL J MED, V328, P1659, DOI 10.1056/NEJM199306103282302
   GALASSI AR, 1993, AM J CARDIOL, V72, P134, DOI 10.1016/0002-9149(93)90148-6
   Gaspardone A, 1998, J AM COLL CARDIOL, V32, P2031, DOI 10.1016/S0735-1097(98)00470-7
   Halcox JPJ, 2002, CIRCULATION, V106, P653, DOI 10.1161/01.CIR.0000025404.78001.D8
   KASKI JC, 1995, J AM COLL CARDIOL, V25, P807, DOI 10.1016/0735-1097(94)00507-M
   Lanza GA, 2004, AM J CARDIOL, V94, P40, DOI 10.1016/j.amjcard.2004.03.027
   Lanza GA, 2003, CIRCULATION, V107, P1378, DOI 10.1161/01.CIR.0000055317.72067.23
   Lanza GA, 1997, CIRCULATION, V96, P821
   LANZA GA, 1994, CIRCULATION, V90, P2695, DOI 10.1161/01.CIR.90.6.2695
   Lanza GA, 1999, AM J CARDIOL, V84, P1187, DOI 10.1016/S0002-9149(99)00532-9
   Lanza GA, 2001, EUR HEART J, V22, P1924, DOI 10.1053/euhj.2001.2624
   Lanza GA, 1999, HERZ, V24, P97, DOI 10.1007/BF03043848
   MASERI A, 1991, J AM COLL CARDIOL, V17, P499, DOI 10.1016/S0735-1097(10)80122-6
   MOSSERI M, 1986, CIRCULATION, V74, P964, DOI 10.1161/01.CIR.74.5.964
   MOTZ W, 1991, AM J CARDIOL, V68, P996, DOI 10.1016/0002-9149(91)90485-4
   NIHOYANNOPOULOS P, 1991, J AM COLL CARDIOL, V18, P1463, DOI 10.1016/0735-1097(91)90676-Z
   OPHERK D, 1981, CIRCULATION, V63, P817, DOI 10.1161/01.CIR.63.4.817
   Panting JR, 2002, NEW ENGL J MED, V346, P1948, DOI 10.1056/NEJMoa012369
   Pasceri V, 1998, J AM COLL CARDIOL, V31, P62, DOI 10.1016/S0735-1097(97)00421-X
   ROSANO GMC, 1995, EUR HEART J, V16, P610, DOI 10.1093/oxfordjournals.eurheartj.a060963
   Rosen SD, 2002, HEART, V87, P513, DOI 10.1136/heart.87.6.513
   SAX FL, 1987, NEW ENGL J MED, V317, P1366, DOI 10.1056/NEJM198711263172202
   Sestito A, 2005, THROMB RES, V116, P25, DOI 10.1016/j.thromres.2004.10.002
   SHAPIRO LM, 1988, BRIT MED J, V296, P170, DOI 10.1136/bmj.296.6616.170-a
   TWEDDEL AC, 1992, BRIT HEART J, V68, P48
   Valeriani M, 2005, EUR HEART J, V26, P975, DOI 10.1093/eurheartj/ehi229
   WIEDERMANN JG, 1995, J AM COLL CARDIOL, V25, P1310, DOI 10.1016/0735-1097(94)00556-6
NR 43
TC 110
Z9 121
U1 0
U2 7
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1355-6037
J9 HEART
JI Heart
PD FEB
PY 2007
VL 93
IS 2
BP 159
EP 166
DI 10.1136/hrt.2005.067330
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 126NX
UT WOS:000243520700006
PM 16399854
OA Green Published
DA 2025-06-11
ER

PT J
AU Almagro, P
   Soler-Cataluña, JJ
   Huerta, A
   González-Segura, D
   Cosío, BG
AF Almagro, Pere
   Soler-Cataluna, Juan Jose
   Huerta, Arturo
   Gonzalez-Segura, Diego
   Cosio, Borja G.
CA CLAVE Study Investigators
TI Impact of comorbidities in COPD clinical control criteria. The CLAVE
   study
SO BMC PULMONARY MEDICINE
LA English
DT Article
DE COPD: Chronic obstructive pulmonary disease; CAT: COPD assessment test;
   Comorbidities; Clinical control criteria; Exacerbations; Charlson index
ID OBSTRUCTIVE PULMONARY-DISEASE; SYSTEMIC INFLAMMATION; METABOLIC
   SYNDROME; OUTCOMES; RISK; DEPRESSION; ANXIETY; CONSEQUENCES; PREVALENCE;
   VALIDATION
AB Background Chronic obstructive pulmonary disease (COPD) frequently coexists with other chronic diseases, namely comorbidities. They negatively impact prognosis, exacerbations and quality of life in COPD patients. However, no studies have been performed to explore the impact of these comorbidities on COPD clinical control criteria.Research question Determine the relationship between individualized comorbidities and COPD clinical control criteria.Study design and methods Observational, multicenter, cross-sectional study performed in Spain involving 4801 patients with severe COPD (< 50 predicted forced expiratory volume in the first second [FEV1%]). Clinical control criteria were defined by the combination of COPD assessment test (CAT) scores (<= 16 vs >= 17) and exacerbations in the previous three months (none vs >= 1). Binary logistic regression adjusted by age and FEV1% was performed to identify comorbidities potentially associated with the lack of control of COPD. Secondary endpoints were the relationship between individualized comorbidities with COPD assessment test and exacerbations within the last three months.Results Most frequent comorbidities were arterial hypertension (51.2%), dyslipidemia (36.0%), diabetes (24.9%), obstructive sleep apnea-hypopnea syndrome (14.9%), anxiety (14.1%), heart failure (11.6%), depression (11.8%), atrial fibrillation (11.5%), peripheral arterial vascular disease (10.4%) and ischemic heart disease (10.1%). After age and FEV1% adjustment, comorbidities related to lack of clinical control were cardiovascular diseases (heart failure, peripheral vascular disease and atrial fibrillation; p < 0.0001), psychologic disorders (anxiety and depression; all p < 0.0001), metabolic diseases (diabetes, arterial hypertension and abdominal obesity; all p < 0.001), sleep disorders (p < 0.0001), anemia (p = 0.015) and gastroesophageal reflux (p < 0.0001). These comorbidities were also related to previous exacerbations and COPD assessment test scores.Interpretation Comorbidities are frequent in patients with severe COPD, negatively impacting COPD clinical control criteria. They are related to health-related quality of life measured by the COPD assessment test. Our results suggest that comorbidities should be investigated and treated in these patients to improve their clinical control.Take-home points Study question: What is the impact of comorbidities on COPD clinical control criteria?Results: Among 4801 patients with severe COPD (27.5% controlled and 72.5% uncontrolled), after adjustment by age and FEV1%, comorbidities related to lack of clinical control were cardiovascular diseases (heart failure, peripheral vascular disease and atrial fibrillation; p < 0.0001), psychologic disorders (anxiety and depression; p < 0.0001), metabolic diseases (diabetes, arterial hypertension and abdominal obesity; p < 0.001), obstructive sleep apnea-hypopnea syndrome (p < 0.0001), anaemia (p = 0.015) and gastroesophageal reflux (p < 0.0001), which were related to previous exacerbations and COPD assessment test scores.Interpretation: Comorbidities are related to health-related quality of life measured by the COPD assessment test scores and history of exacerbations in the previous three months.Take-home pointsStudy question: What is the impact of comorbidities on COPD clinical control criteria?Results: Among 4801 patients with severe COPD (27.5% controlled and 72.
   5% uncontrolled), after adjustment by age and FEV1%, comorbidities related to lack of clinical control were cardiovascular diseases (heart failure, peripheral vascular disease and atrial fibrillation; p < 0.0001), psychologic disorders (anxiety and depression; p < 0.0001), metabolic diseases (diabetes, arterial hypertension and abdominal obesity; p < 0.001), obstructive sleep apnea-hypopnea syndrome (p < 0.0001), anaemia (p = 0.015) and gastroesophageal reflux (p < 0.0001), which were related to previous exacerbations and COPD assessment test scores.Interpretation: Comorbidities are related to health-related quality of life measured by the COPD assessment test scores and history of exacerbations in the previous three months.Take-home pointsStudy question: What is the impact of comorbidities on COPD clinical control criteria?Results: Among 4801 patients with severe COPD (27.5% controlled and 72.5% uncontrolled), after adjustment by age and FEV1%, comorbidities related to lack of clinical control were cardiovascular diseases (heart failure, peripheral vascular disease and atrial fibrillation; p < 0.0001), psychologic disorders (anxiety and depression; p < 0.0001), metabolic diseases (diabetes, arterial hypertension and abdominal obesity; p < 0.001), obstructive sleep apnea-hypopnea syndrome (p < 0.0001), anaemia (p = 0.015) and gastroesophageal reflux (p < 0.0001), which were related to previous exacerbations and COPD assessment test scores.Interpretation: Comorbidities are related to health-related quality of life measured by the COPD assessment test scores and history of exacerbations in the previous three months.
C1 [Almagro, Pere] H Mutua Terrassa Univ Hosp, Internal Med Dept, Multimorbid Patients Unit, Plaza Doctor Robert 5, Barcelona 08221, Spain.
   [Soler-Cataluna, Juan Jose] Univ Valencia, Hosp Arnau Vilanova Lliria, Dept Pneumol, Med Dept, Valencia, Spain.
   [Soler-Cataluna, Juan Jose] CIBERES, Valencia, Spain.
   [Huerta, Arturo] Emergency Dept, Pulm & Crit Care Div, Clin Sagrada Familia, Barcelona, Spain.
   [Gonzalez-Segura, Diego] Med Dept, Chiesi SAU, Barcelona, Spain.
   [Cosio, Borja G.] H Univ Son Espases Hosp IdISBa, Dept Pneumol, Balear Isl, Palma De Mallorca, Balear Isl, Spain.
   [Cosio, Borja G.] IBERES, Palma De Mallorca, Balear Isl, Spain.
C3 University Hospital Arnau de Vilanova; University of Valencia; CIBER -
   Centro de Investigacion Biomedica en Red; CIBERES
RP Almagro, P (corresponding author), H Mutua Terrassa Univ Hosp, Internal Med Dept, Multimorbid Patients Unit, Plaza Doctor Robert 5, Barcelona 08221, Spain.
EM perealmagro@gmail.com
RI Cosio, Borja/P-4963-2017; Huerta, Arturo/T-9954-2019; Soler-Cataluña,
   Juan/HKV-7421-2023
OI Soler-Cataluna, Juan Jose/0000-0003-1134-0783
FU Chiesi Espana SAU
FX The study described within the paper was sponsored by Chiesi Espana SAU.
CR Adeloye D, 2015, J GLOB HEALTH, V5, P186, DOI 10.7189/jogh.05.020415
   Almagro P, 2012, CHEST, V142, P1126, DOI 10.1378/chest.11-2413
   Almagro P, 2020, INT J CHRONIC OBSTR, V15, P755, DOI 10.2147/COPD.S238214
   [Anonymous], 2021, GOLD Reports
   Armentaro G, 2023, EUR J CLIN INVEST, V53, DOI 10.1111/eci.13887
   Axson EL, 2021, THORAX, V76, P807, DOI 10.1136/thoraxjnl-2020-216390
   Burke H, 2021, EUR RESPIR REV, V30, DOI 10.1183/16000617.0041-2021
   Casanova C, 2014, RESP RES, V15, DOI 10.1186/1465-9921-15-3
   Celli BR, 2019, NEW ENGL J MED, V381, P1257, DOI 10.1056/NEJMra1900500
   Chang SS, 2012, J AM GERIATR SOC, V60, P1839, DOI 10.1111/j.1532-5415.2012.04171.x
   CHARLSON ME, 1987, J CHRON DIS, V40, P373, DOI 10.1016/0021-9681(87)90171-8
   Chen WJ, 2015, LANCET RESP MED, V3, P631, DOI 10.1016/S2213-2600(15)00241-6
   Clarke DM, 2009, MED J AUSTRALIA, V190, pS54
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Díez-Manglano J, 2014, INTERN EMERG MED, V9, P419, DOI 10.1007/s11739-013-0945-7
   Divo M, 2012, AM J RESP CRIT CARE, V186, P155, DOI 10.1164/rccm.201201-0034OC
   Divo MJ, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0193143
   Fabbri LM, 2008, EUR RESPIR J, V31, P204, DOI 10.1183/09031936.00114307
   Gudmundsson G, 2005, EUR RESPIR J, V26, P414, DOI 10.1183/09031936.05.00078504
   Hansen NS, 2020, RESP CARE, V65, P1120, DOI 10.4187/respcare.07136
   Houben-Wilkes S, 2017, AM J RESP CRIT CARE, V195, P189, DOI 10.1164/rccm.201602-0354OC
   Hughes LD, 2013, AGE AGEING, V42, P62, DOI 10.1093/ageing/afs100
   Jones PW, 2009, EUR RESPIR J, V34, P648, DOI 10.1183/09031936.00102509
   Soler-Cataluña JJ, 2021, INT J CHRONIC OBSTR, V16, P137, DOI 10.2147/COPD.S285385
   Soler-Cataluña JJ, 2020, CHEST, V157, P1138, DOI 10.1016/j.chest.2019.11.004
   Karloh M, 2016, CHEST, V149, P413, DOI 10.1378/chest.15-1752
   Kim SH, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000006826
   Lee H, 2017, INT J CHRONIC OBSTR, V12, P3301, DOI 10.2147/COPD.S145910
   Lipovec NC, 2016, COPD, V13, P399, DOI 10.3109/15412555.2016.1140732
   Mannino DM, 2008, EUR RESPIR J, V32, P962, DOI 10.1183/09031936.00012408
   Miller J, 2013, RESP MED, V107, P1376, DOI 10.1016/j.rmed.2013.05.001
   Miravitlles M, 2021, ARCH BRONCONEUMOL, V57, P122, DOI 10.1016/j.arbres.2020.06.003
   Miravitlles M, 2020, RESPIROLOGY, V25, P1136, DOI 10.1111/resp.13811
   Miyazaki M, 2014, RESP RES, V15, DOI 10.1186/1465-9921-15-13
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Müllerova H, 2013, CHEST, V144, P1163, DOI 10.1378/chest.12-2847
   Nibber A, 2017, COPD, V14, P504, DOI 10.1080/15412555.2017.1350154
   Pelaia C, 2021, NUTRIENTS, V13, DOI 10.3390/nu13082811
   Putcha N, 2018, ANN AM THORAC SOC, V15, P710, DOI 10.1513/AnnalsATS.201708-687OC
   Raherison C, 2018, BMC PULM MED, V18, DOI 10.1186/s12890-018-0684-7
   Read JR, 2017, J AFFECT DISORDERS, V221, P36, DOI 10.1016/j.jad.2017.06.009
   Rubio MC, 2021, RESP RES, V22, DOI 10.1186/s12931-021-01633-y
   Sadatsafavi M, 2021, EUR RESPIR J, V57, DOI 10.1183/13993003.02122-2020
   Smith MC, 2014, INT J CHRONIC OBSTR, V9, P871, DOI 10.2147/COPD.S49621
   Soler-Cataluña JJ, 2022, ARCH BRONCONEUMOL, V58, P159, DOI 10.1016/j.arbres.2021.05.011
   Soler-Cataluña JJ, 2018, INT J CHRONIC OBSTR, V13, P3719, DOI 10.2147/COPD.S178149
   Vanfleteren LEGW, 2013, AM J RESP CRIT CARE, V187, P728, DOI 10.1164/rccm.201209-1665OC
   Wacker ME, 2016, BMC PULM MED, V16, DOI 10.1186/s12890-016-0238-9
   Wang HD, 2016, LANCET, V388, P1459, DOI 10.1016/S0140-6736(16)31012-1
   Xu WN, 2008, AM J RESP CRIT CARE, V178, P913, DOI 10.1164/rccm.200804-619OC
   Yin HL, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000006836
NR 51
TC 16
Z9 16
U1 2
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2466
J9 BMC PULM MED
JI BMC Pulm. Med.
PD JAN 2
PY 2024
VL 24
IS 1
AR 6
DI 10.1186/s12890-023-02758-0
PG 10
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA DX2P0
UT WOS:001135319300010
PM 38166965
OA gold
DA 2025-06-11
ER

PT J
AU Eleazu, CO
   Obeten, UN
   Ozor, G
   Njemanze, CC
   Eleazu, KC
   Egedigwe-Ekeleme, AC
   Okorie, UC
   Ogunwa, SC
   Adeolu, A
   Okoh, PFN
   Kalu, AO
   Onyia, CJ
   Onyia, S
   Ossai, P
   Chikezie, CC
   Odii, BC
   Obi, V
   Igwe, VM
   Amobi, CA
   Ugada, OJ
   Kalu, WO
   Kanu, S
AF Eleazu, Chinedum O.
   Obeten, Uket N.
   Ozor, Gerald
   Njemanze, Canice C.
   Eleazu, Kate C.
   Egedigwe-Ekeleme, Agatha C.
   Okorie, Uchechukwu C.
   Ogunwa, Shedrack C.
   Adeolu, Adewale, I
   Okoh, Petra-Favour N.
   Kalu, Abigail O.
   Onyia, Chinazaekpere J.
   Onyia, Scholastica
   Ossai, Precious
   Chikezie, Chioma C.
   Odii, Bright C.
   Obi, Valentine
   Igwe, Valeria M.
   Amobi, Chidiebere A.
   Ugada, Ogechukwu J.
   Kalu, Winner O.
   Kanu, Shedrach
TI Tert-butylhydroquinone abrogates fructose-induced insulin resistance in
   rats via mitigation of oxidant stress, NFkB-mediated inflammation in the
   liver but not the skeletal muscle of high fructose drinking rats
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE antioxidants; hypertriglyceridemia; inflammation mediators; nutrition
   therapy; insulin resistance
ID INDUCED METABOLIC SYNDROME; TYPE-2 DIABETES-MELLITUS; OXIDATIVE STRESS;
   LIPID-METABOLISM; ANTIOXIDANT STATUS; KAPPA-B; DIET; METFORMIN;
   COMBINATION; DYSFUNCTION
AB The effect of 21% fructose drinking water (FDW) (w/v) on some parameters of metabolic syndrome, hepatic, and skeletal muscular histology of rats was studied using standard techniques. Twenty male albino rats were divided into four groups of 5 rats each in this in vivo study. Group I received distilled water, group 2 received FDW, group 3 received FDW and metformin (300 mg/kg body weight daily, orally), group 4 received FDW and 1% tert-butylhydroquinone feed. FDW changed the serum leptin, triacylglycerol, very low-density lipoprotein, and C-reactive protein levels of the rats, inducing hypertriglyceridemia, oxidative stress, and inflammation in their liver (but not the skeletal muscle) and insulin resistance which were modulated with metformin and tBHQ as corroborated by liver and muscle histology. The study reveals the potentials of metformin and tBHQ in mitigating hepatic and skeletal muscular morphological changes arising from exposure to high fructose drinks. Practical applications There has been an increase in the global consumption of fructose (either as a sweetner in beverages or soft and carbonated drinks) in the last few decades and this has been positively correlated with the global increase in metabolic complications. Regular intake of fructose contributes to the pathogenesis of lipid disorders, oxidant stress, and chronic inflammation, which are linked with the metabolic syndrome components (MetS) (obesity, insulin resistance, and cardiovascular diseases) as well as increased morbidity and mortality. Given that the approaches that have been applied to treat the MetS have not been able to totally arrest it, currenty study which showed that tBHQ abrogated fructose-induced insulin resistance, dyslipidemia, hepatic, and skeletal muscular pathology in the rats places tBHQ in the spotlight as a nutraceutical that could be of relevance in mitigating high dietary fructose-induced hepatic and skeletal muscular pathology.
C1 [Eleazu, Chinedum O.; Obeten, Uket N.; Ozor, Gerald; Njemanze, Canice C.; Egedigwe-Ekeleme, Agatha C.; Okorie, Uchechukwu C.; Ogunwa, Shedrack C.; Okoh, Petra-Favour N.; Kalu, Abigail O.; Onyia, Chinazaekpere J.; Onyia, Scholastica; Ossai, Precious; Chikezie, Chioma C.; Odii, Bright C.; Obi, Valentine; Igwe, Valeria M.; Amobi, Chidiebere A.; Ugada, Ogechukwu J.; Kanu, Shedrach] Alex Ekwueme Fed Univ, Dept Biochem, Nudfu Alike, Ebonyi State, Nigeria.
   [Eleazu, Kate C.] Ebonyi State Univ, Dept Biochem, Abakaliki, Nigeria.
   [Adeolu, Adewale, I] Alex Ekwueme Fed Univ, Dept Agr, Nudfu Aiike, Nigeria.
   [Kalu, Winner O.] Rhema Univ, Dept Biochem, Aba, Nigeria.
RP Eleazu, CO (corresponding author), Alex Ekwueme Fed Univ, Dept Biochem, Nudfu Alike, Ebonyi State, Nigeria.
EM eleazon@yahoo.com
RI Eleazu, Chinedum/AAY-8306-2020
OI Eleazu, Chinedum/0000-0002-1574-0445
CR Aboonabi A., 2014, J CYTOLOGY HISTOLOGY, V6, P1
   Aeberli I, 2013, DIABETES CARE, V36, P150, DOI 10.2337/dc12-0540
   Al Batran R, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0064751
   Amitani M, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00051
   Aydin A, 2001, CLIN BIOCHEM, V34, P65, DOI 10.1016/S0009-9120(00)00199-5
   Baena M, 2016, SCI REP-UK, V6, DOI 10.1038/srep26149
   Bahlil Y, 2021, NUTR FOOD SCI, V51, P605, DOI 10.1108/NFS-05-2020-0175
   Bhatia S, 2003, CLIN BIOCHEM, V36, P557, DOI 10.1016/S0009-9120(03)00094-8
   Bhutani Jaikrit, 2014, Indian J Endocrinol Metab, V18, P868, DOI 10.4103/2230-8210.141388
   Bokelmann I, 2008, MOL MED, V14, P20, DOI 10.2119/2007-00084.Bokelmann
   Botezelli JD, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-78
   Cavarape A, 2001, J ENDOCRINOL INVEST, V24, P838, DOI 10.1007/BF03343940
   Castro MC, 2015, LIFE SCI, V137, P1, DOI 10.1016/j.lfs.2015.07.010
   CHAN KM, 1994, CRIT REV FOOD SCI, V34, P403, DOI 10.1080/10408399409527669
   Charan J, 2013, J PHARMACOL PHARMACO, V4, P303, DOI 10.4103/0976-500X.119726
   Chatterjee PK, 2000, KIDNEY INT, V58, P658, DOI 10.1046/j.1523-1755.2000.00212.x
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Demirtas CY, 2018, BRATISL MED J, V119, P36, DOI 10.4149/BLL_2018_008
   Dupas J, 2017, BIOMED RES INT, V2017, DOI 10.1155/2017/2494067
   Dupas J, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0146821
   Dziadek K, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112638
   Eastham R.D., 1985, BIOCH VALUES CLIN ME, V7th ed.
   Eleazu CO, 2014, TOXICOL REP, V1, P674, DOI 10.1016/j.toxrep.2014.08.013
   Eleazu C, 2021, J FOOD BIOCHEM, V45, DOI 10.1111/jfbc.13626
   Eleazu C, 2022, ARCH PHYSIOL BIOCHEM, V128, P1088, DOI 10.1080/13813455.2020.1752258
   Eleazu C, 2019, ENDOCR METAB IMMUNE, V19, P1032, DOI 10.2174/1871530319666190119101058
   Eleazu C, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00234
   Eleazu C, 2017, BIOMED PHARMACOTHER, V88, P644, DOI 10.1016/j.biopha.2017.01.125
   Eleazu CO, 2016, PHARM BIOL, V54, P91, DOI 10.3109/13880209.2015.1016181
   Erejuwa OO, 2010, INT J MOL SCI, V11, P2056, DOI 10.3390/ijms11052056
   FAO/WHO, 1999, FORTYNINTH REPORT JO
   Farag MM, 2020, DUBAI MED J, V3, P76, DOI 10.1159/000506899
   Ferrier D.R., 2014, LIPPINCOTTS ILLUSTRA, V6th ed., P622
   Festing Michael F W, 2002, ILAR J, V43, P244
   Francini F, 2010, LIFE SCI, V86, P965, DOI 10.1016/j.lfs.2010.05.005
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Girard A, 2006, NUTRITION, V22, P758, DOI 10.1016/j.nut.2006.05.006
   GOTH L, 1991, CLIN CHIM ACTA, V196, P143, DOI 10.1016/0009-8981(91)90067-M
   HABIG WH, 1974, J BIOL CHEM, V249, P7130
   Higashi Y, 2009, CIRC J, V73, P411, DOI 10.1253/circj.CJ-08-1102
   Huang W., 2018, J TRADITIONAL CHINES, V5, P128, DOI [10.1016/j.jtcms.2018.03.004, DOI 10.1016/J.JTCMS.2018.03.004]
   Hurrle S, 2017, BIOMED J, V40, P257, DOI 10.1016/j.bj.2017.06.007
   Iikuni Noriko, 2008, Current Immunology Reviews, V4, P70, DOI 10.2174/157339508784325046
   Jaiswal N, 2015, FREE RADICAL RES, V49, P1055, DOI 10.3109/10715762.2015.1031662
   Jin W, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/502564
   Jones N, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-21461-4
   Kelany ME, 2017, CAN J PHYSIOL PHARM, V95, P140, DOI 10.1139/cjpp-2016-0152
   Khaki Z., 2016, IRANIAN J VET MED, V11, P55, DOI [10.22059/ijvm.2017.60212, DOI 10.22059/IJVM.2017.60212]
   Kim HY, 2010, BRIT J NUTR, V103, P502, DOI 10.1017/S0007114509991978
   Lala V., 2022, StatPearls internet
   Lawrence T, 2009, CSH PERSPECT BIOL, V1, DOI 10.1101/cshperspect.a001651
   Lê KA, 2006, AM J CLIN NUTR, V84, P1374, DOI 10.1093/ajcn/84.6.1374
   Mamikutty N, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/263897
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   MAYES PA, 1976, BIOCHEM SOC T, V4, P575, DOI 10.1042/bst0040575
   MEYER M, 1993, EMBO J, V12, P2005, DOI 10.1002/j.1460-2075.1993.tb05850.x
   Nakhjavani M, 2011, REDOX REP, V16, P193, DOI 10.1179/1351000211Y.0000000008
   Nammour Fadel E, 2003, Endocr Pract, V9, P307
   Özkan H, 2020, ANKARA UNIV VET FAK, V67, P387, DOI 10.33988/auvfd.645713
   Pasko P, 2010, PLANT FOOD HUM NUTR, V65, P146, DOI 10.1007/s11130-010-0164-6
   Pasquali R, 2000, J CLIN ENDOCR METAB, V85, P2767, DOI 10.1210/jc.85.8.2767
   Pektas MB, 2016, BIOMED RES INT, V2016, DOI 10.1155/2016/8014252
   PENNY AF, 1988, ANN CLIN BIOCHEM, V25, P181, DOI 10.1177/000456328802500209
   Prabhakar P, 2015, EUR J NUTR, V54, P1117, DOI 10.1007/s00394-014-0788-7
   Rao P.S., 2011, FREE RADICALS ANTIOX, V1, P2, DOI DOI 10.5530/AX.2011.4.2
   Rector RS, 2010, AM J PHYSIOL-ENDOC M, V298, pE1179, DOI 10.1152/ajpendo.00703.2009
   REITMAN S, 1957, AM J CLIN PATHOL, V28, P56, DOI 10.1093/ajcp/28.1.56
   SALAS M, 1963, J BIOL CHEM, V238, P3535
   Seghrouchni I, 2002, CLIN CHIM ACTA, V321, P89, DOI 10.1016/S0009-8981(02)00099-2
   Sen CK., 1998, Oxidative Stress in Skeletal Muscles, P127
   Shapiro A, 2008, AM J PHYSIOL-REG I, V295, pR1370, DOI 10.1152/ajpregu.00195.2008
   Shi XL, 1999, MOL CELL BIOCHEM, V194, P63, DOI 10.1023/A:1006904904514
   Shih AY, 2005, J NEUROSCI, V25, P10321, DOI 10.1523/JNEUROSCI.4014-05.2005
   Shin SM, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/763257
   Shivananda N.B., 2007, MANIPLE MANUEL CLIN, V4th ed., P149
   Shokri F, 2019, CRESCENT J MED BIOL, V6, P31
   Shoorei H, 2020, HUM EXP TOXICOL, V39, P1019, DOI 10.1177/0960327120909525
   Stadler K, 2013, ADV EXP MED BIOL, V771, P272
   Suleiman JB, 2020, BIOMED PHARMACOTHER, V131, DOI 10.1016/j.biopha.2020.110781
   Tappy L, 2010, PHYSIOL REV, V90, P23, DOI 10.1152/physrev.00019.2009
   Tasset I, 2010, NEUROSIGNALS, V18, P24, DOI 10.1159/000243650
   Teff KL, 2004, J CLIN ENDOCR METAB, V89, P2963, DOI 10.1210/jc.2003-031855
   ter Horst KW, 2017, NUTRIENTS, V9, DOI 10.3390/nu9090981
   Tietz NW, 1995, Clinical guide to laboratory tests, P518
   Tillman EJ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0107206
   Vasudevan D.M., 2013, TXB BIOCH MED STUDEN, V7th ed., P305
   Voet D., 2006, FUNDAMENTALS BIOCH, V2nd ed., P458
   Wu DD, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/2715718
   Yadav H, 2007, NUTRITION, V23, P62, DOI 10.1016/j.nut.2006.09.002
   Zamami Y, 2008, BIOL PHARM BULL, V31, P2103, DOI 10.1248/bpb.31.2103
   Zhang YT, 2015, SCI REP-UK, V5, DOI 10.1038/srep13005
   Zhu TT, 2022, INDIAN J PHARMACOL, V54, P118, DOI 10.4103/ijp.ijp_440_21
NR 93
TC 5
Z9 5
U1 1
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD DEC
PY 2022
VL 46
IS 12
DI 10.1111/jfbc.14473
EA OCT 2022
PG 18
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA 7T2OX
UT WOS:000868808000001
PM 36251589
OA gold
DA 2025-06-11
ER

PT J
AU Sampath, H
   Lloyd, RS
AF Sampath, Harini
   Lloyd, R. Stephen
TI Roles of OGG1 in transcriptional regulation and maintenance of metabolic
   homeostasis
SO DNA REPAIR
LA English
DT Review
DE Base excision repair; Metabolic syndrome; Mitochondrial DNA repair
ID BASE-EXCISION-REPAIR; MITOCHONDRIAL-DNA DAMAGE; HUMAN 8-OXOGUANINE-DNA
   GLYCOSYLASE; PROINFLAMMATORY GENE-EXPRESSION; SER326CYS POLYMORPHISM;
   G-QUADRUPLEX; OXIDATIVE STRESS; CANCER-RISK; HOGG1; ASSOCIATION
AB Cellular damage produced by conditions generating oxidative stress have far-reaching implications in human disease that encompass, but are not restricted to aging, cardiovascular disease, type 2 diabetes, airway inflammation/asthma, cancer, and metabolic syndrome including visceral obesity, insulin resistance, fatty liver disease, and dyslipidemia. Although there are numerous sources and cellular targets of oxidative stress, this review will highlight literature that has investigated downstream consequences of oxidatively-induced DNA damage in both nuclear and mitochondrial genomes. The presence of such damage can in turn, directly and indirectly modulate cellular transcriptional and repair responses to such stressors. As such, the persistence of base damage can serve as a key regulator in coordinated gene-response cascades. Conversely, repair of these DNA lesions serves as both a suppressor of mutagenesis and by inference carcinogenesis, and as a signal for the cessation of ongoing oxidative stress. A key enzyme in all these processes is 8-oxoguanine DNA glycosylase (OGG1), which, via non-catalytic binding to oxidatively-induced DNA damage in promoter regions, serves as a nucleation site around which changes in large-scale regulation of inflammation-associated gene expression can occur. Further, the catalytic function of OGG1 can alter the three-dimensional structure of specialized DNA sequences, leading to changes in transcriptional profiles. This review will concentrate on adverse deleterious health effects that are associated with both the diminution of OGG1 activity via population-specific polymorphic variants and the complete loss of OGG1 in murine models. This mouse model displays diet- and age-related induction of metabolic syndrome, highlighting a key role for OGG1 in protecting against these phenotypes. Conversely, recent investigations using murine models having enhanced global expression of a mitochondrial-targeted OGG1 demonstrate that they are highly resistant to diet-induced disease. These data suggest strategies through which therapeutic interventions could be designed for reducing or limiting adverse human health consequences to these ubiquitous stressors.
C1 [Sampath, Harini] Rutgers State Univ, Dept Nutr Sci, New Brunswick, NJ 08901 USA.
   [Sampath, Harini] Rutgers State Univ, New Jersey Inst Food Nutr & Hlth, New Brunswick, NJ 08901 USA.
   [Lloyd, R. Stephen] Oregon Hlth & Sci Univ, Dept Mol & Med Genet, Oregon Inst Occupat Hlth Sci, Portland, OR 97239 USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University System; Rutgers University New Brunswick; Oregon Health &
   Science University
RP Sampath, H (corresponding author), Rutgers State Univ, Dept Nutr Sci, New Brunswick, NJ 08901 USA.; Sampath, H (corresponding author), Rutgers State Univ, New Jersey Inst Food Nutr & Hlth, New Brunswick, NJ 08901 USA.; Lloyd, RS (corresponding author), Oregon Hlth & Sci Univ, Dept Mol & Med Genet, Oregon Inst Occupat Hlth Sci, Portland, OR 97239 USA.
EM harini.sampath@rutgers.edu; lloydst@ohsu.edu
OI Lloyd, R. Stephen/0000-0001-7273-372X
FU NIH [R01 DK075974, DK100640]; Oregon Institute for Occupational Health
   Sciences; New Jersey Institute for Food, Nutrition, and Health at
   Rutgers University
FX We wish to thank Dr. Vladimir Vartanian who has made invaluable
   contributions to this work. We also wish to thank Drs. Amanda K.
   McCullough, Steve Boldogh, Cindy Burrows, and Scott Ballinger for their
   insightful comments and recommendations on this review. These
   investigations were supported by grants from the NIH, R01 DK075974,
   DK100640. Generous additional support has been provided by the Oregon
   Institute for Occupational Health Sciences and the New Jersey Institute
   for Food, Nutrition, and Health at Rutgers University.
CR Aguilera-Aguirre L, 2017, AM J PHYSIOL-LUNG C, V313, pL1058, DOI 10.1152/ajplung.00141.2017
   Alanazi M, 2017, PATHOL ONCOL RES, V23, P525, DOI 10.1007/s12253-016-0146-6
   Allgayer J, 2016, NUCLEIC ACIDS RES, V44, P7267, DOI 10.1093/nar/gkw473
   An N, 2016, ACS CHEM BIOL, V11, P500, DOI 10.1021/acschembio.5b00844
   Anderson SM, 2018, REPROD TOXICOL, V79, P8, DOI 10.1016/j.reprotox.2018.04.012
   Ba XQ, 2018, REDOX BIOL, V14, P669, DOI 10.1016/j.redox.2017.11.008
   Ba XQ, 2014, J IMMUNOL, V192, P2384, DOI 10.4049/jimmunol.1302472
   Ballinger SW, 2000, CIRC RES, V86, P960, DOI 10.1161/01.RES.86.9.960
   Baptiste BA, 2018, FREE RADICAL BIO MED, V124, P149, DOI 10.1016/j.freeradbiomed.2018.05.094
   Bhakat KK, 2006, MOL CELL BIOL, V26, P1654, DOI 10.1128/MCB.26.5.1654-1665.2006
   Boiteux S, 2017, FREE RADICAL BIO MED, V107, P179, DOI 10.1016/j.freeradbiomed.2016.11.042
   Boldogh I, 2012, J BIOL CHEM, V287, P20769, DOI 10.1074/jbc.C112.364620
   Bravard A, 2006, MOL CELL BIOL, V26, P7430, DOI 10.1128/MCB.00624-06
   Bravard A, 2010, MUTAT RES-FUND MOL M, V685, P61, DOI 10.1016/j.mrfmmm.2009.09.013
   Bravard A, 2009, CANCER RES, V69, P3642, DOI 10.1158/0008-5472.CAN-08-3943
   Bray A.W., 2017, Curr Opin Cardiol
   Campalans A, 2015, MOL CELL BIOL, V35, P1648, DOI 10.1128/MCB.00134-15
   Chen L, 2003, J UROLOGY, V170, P2471, DOI 10.1097/01.ju.0000087498.23008.bb
   Cheng Y, 2013, CELL DEATH DIS, V4, DOI 10.1038/cddis.2013.254
   Choudhary S, 2016, J INNATE IMMUN, V8, P143, DOI 10.1159/000442254
   Cividini F, 2016, J BIOL CHEM, V291, P26515, DOI 10.1074/jbc.M116.754481
   Corella D, 2018, J ACAD NUTR DIET, V118, P589, DOI 10.1016/j.jand.2017.09.025
   Daimon M, 2009, BIOCHEM BIOPH RES CO, V386, P26, DOI 10.1016/j.bbrc.2009.05.119
   Dalhus B, 2011, STRUCTURE, V19, P117, DOI 10.1016/j.str.2010.09.023
   de Souza-Pinto NC, 2001, CANCER RES, V61, P5378
   Costa EFD, 2016, J CANCER RES CLIN, V142, P1917, DOI 10.1007/s00432-016-2202-8
   Ding Y, 2017, J AM CHEM SOC, V139, P2569, DOI 10.1021/jacs.6b12604
   Dizdaroglu M, 2017, MUTAT RES-REV MUTAT, V771, P99, DOI 10.1016/j.mrrev.2017.02.001
   Dodson ML, 2002, FREE RADICAL BIO MED, V32, P678, DOI 10.1016/S0891-5849(02)00767-0
   Dunham-Snary KJ, 2018, EBIOMEDICINE, V36, P316, DOI 10.1016/j.ebiom.2018.08.036
   Fang EF, 2016, NAT REV MOL CELL BIO, V17, P308, DOI 10.1038/nrm.2016.14
   Fleming A.M., 2019, CHEM RES TOXICOL
   Fleming AM, 2018, BIOCHEMISTRY-US, V57, P991, DOI 10.1021/acs.biochem.7b01172
   Fleming AM, 2017, ACS CHEM BIOL, V12, P2417, DOI 10.1021/acschembio.7b00636
   Fleming AM, 2017, METHOD ENZYMOL, V591, P187, DOI 10.1016/bs.mie.2017.03.004
   Fleming AM, 2017, P NATL ACAD SCI USA, V114, P2604, DOI 10.1073/pnas.1619809114
   Fleming AM, 2013, CHEM RES TOXICOL, V26, P593, DOI 10.1021/tx400028y
   Garcia-Rodriguez A, 2018, ANDROLOGIA, V50, DOI 10.1111/and.13115
   Genereux JC, 2010, CHEM REV, V110, P1642, DOI 10.1021/cr900228f
   Gotoh N, 2018, INT J HEMATOL, V108, P246, DOI 10.1007/s12185-018-2464-9
   Hajas G, 2013, FREE RADICAL BIO MED, V61, P384, DOI 10.1016/j.freeradbiomed.2013.04.011
   Han YH, 2016, DIABETES, V65, P2639, DOI 10.2337/db16-0283
   Hashizume M, 2013, AM J PHYSIOL-LUNG C, V304, pL287, DOI 10.1152/ajplung.00071.2012
   Hill JW, 2006, NUCLEIC ACIDS RES, V34, P1620, DOI 10.1093/nar/gkl060
   Hill JW, 2001, NUCLEIC ACIDS RES, V29, P430, DOI 10.1093/nar/29.2.430
   Hosford ME, 2004, J AM CHEM SOC, V126, P9540, DOI 10.1021/ja047981q
   Howard MJ, 2018, DNA REPAIR, V71, P101, DOI 10.1016/j.dnarep.2018.08.013
   Hu JP, 2005, NUCLEIC ACIDS RES, V33, P3271, DOI 10.1093/nar/gki636
   Hung RJ, 2005, AM J EPIDEMIOL, V162, P925, DOI 10.1093/aje/kwi318
   Indiani C, 2013, FRONT BIOSCI-LANDMRK, V18, P312, DOI 10.2741/4102
   Iwahara J, 2018, METHODS, V148, P57, DOI 10.1016/j.ymeth.2018.05.004
   Kabzinski J, 2018, POL J SURG, V90, P13, DOI 10.5604/01.3001.0011.7486
   Kelley SO, 1999, MET IONS BIOL SYST, V36, P211
   Kim SJ, 2014, J BIOL CHEM, V289, P6165, DOI 10.1074/jbc.M113.515130
   Kolbanovskiy M, 2017, BIOCHEMISTRY-US, V56, P3008, DOI 10.1021/acs.biochem.7b00295
   Komakula SSB, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-33151-1
   Le Marchand L, 2002, CANCER EPIDEM BIOMAR, V11, P409
   Lee B, 2014, REV ENDOCR METAB DIS, V15, P149, DOI 10.1007/s11154-013-9283-3
   Lee BC, 2014, BBA-MOL BASIS DIS, V1842, P446, DOI 10.1016/j.bbadis.2013.05.017
   Li GP, 2012, FREE RADICAL BIO MED, V52, P392, DOI 10.1016/j.freeradbiomed.2011.10.490
   Li X., 2019, CELLS, V8
   Liao J, 2008, MOL CARCINOGEN, V47, P638, DOI 10.1002/mc.20427
   Liu XC, 2018, INT OPHTHALMOL, V38, P1451, DOI 10.1007/s10792-017-0606-3
   Lloyd RS, 2000, METH MOL B, V160, P3
   Mabley JG, 2004, FASEB J, V18, P290, DOI 10.1096/fj.04-2278fje
   Marsin S, 2003, J BIOL CHEM, V278, P44068, DOI 10.1074/jbc.M306160200
   Maslowska KH, 2019, ENVIRON MOL MUTAGEN, V60, P368, DOI 10.1002/em.22267
   Maynard S, 2015, CSH PERSPECT MED, V5, DOI 10.1101/cshperspect.a025130
   McCullough AK, 1999, ANNU REV BIOCHEM, V68, P255, DOI 10.1146/annurev.biochem.68.1.255
   Nakanishi N, 2013, MUTAGENESIS, V28, P117, DOI 10.1093/mutage/ges060
   Omaga CA, 2018, BIOCHEMISTRY-US, V57, P2958, DOI 10.1021/acs.biochem.8b00226
   Pal R, 2015, J BIOL CHEM, V290, P22520, DOI 10.1074/jbc.M115.651042
   Pan L, 2016, J BIOL CHEM, V291, P25553, DOI 10.1074/jbc.M116.751453
   Panduri V, 2009, FREE RADICAL BIO MED, V47, P750, DOI 10.1016/j.freeradbiomed.2009.06.010
   Pastukh V, 2015, AM J PHYSIOL-LUNG C, V309, pL1367, DOI 10.1152/ajplung.00236.2015
   Perillo B, 2008, SCIENCE, V319, P202, DOI 10.1126/science.1147674
   Rachek LI, 2002, J BIOL CHEM, V277, P44932, DOI 10.1074/jbc.M208770200
   Rachek LI, 2006, DIABETES, V55, P1022, DOI 10.2337/diabetes.55.04.06.db05-0865
   Ramdzan ZM, 2014, PLOS BIOL, V12, DOI 10.1371/journal.pbio.1001807
   Redstone SCJ, 2019, CHEM RES TOXICOL, V32, P437, DOI 10.1021/acs.chemrestox.8b00332
   Rogers RA, 2018, ACS OMEGA, V3, P9630, DOI 10.1021/acsomega.8b01551
   Saitoh T, 2001, MUTAT RES-DNA REPAIR, V486, P31, DOI 10.1016/S0921-8777(01)00078-7
   Saki M, 2017, FREE RADICAL BIO MED, V107, P216, DOI 10.1016/j.freeradbiomed.2016.11.050
   Sampath H, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051697
   Sanders LH, 2017, TOXICOL SCI, V158, P188, DOI 10.1093/toxsci/kfx086
   Sedgwick B, 2002, ONCOGENE, V21, P8886, DOI 10.1038/sj.onc.1205998
   Sharma P., 2019, MITOCHONDRIAL DNA IN, V8
   Sliwinska A, 2016, J NEUROL SCI, V368, P155, DOI 10.1016/j.jns.2016.07.008
   Smolarz B, 2018, ANTICANCER RES, V38, P5223, DOI 10.21873/anticanres.12846
   Strickland FM, 1997, CLIN PLAST SURG, V24, P637
   Sutton MD, 2000, ANNU REV GENET, V34, P479, DOI 10.1146/annurev.genet.34.1.479
   Synowiec E, 2012, EXP EYE RES, V98, P58, DOI 10.1016/j.exer.2012.02.008
   Tan YB, 2017, ANN AM THORAC SOC, V14, pS210, DOI 10.1513/AnnalsATS.201706-438MG
   Thameem F, 2010, HUM HERED, V70, P97, DOI 10.1159/000291964
   Torres-Gonzalez M, 2014, AM J PHYSIOL-CELL PH, V306, pC221, DOI 10.1152/ajpcell.00140.2013
   Touati E, 2006, HELICOBACTER, V11, P494, DOI 10.1111/j.1523-5378.2006.00442.x
   Vartanian V, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0181687
   Verdine GL, 2003, ANNU REV BIOCHEM, V72, P337, DOI 10.1146/annurev.biochem.72.121801.161447
   Verdine GL, 1997, CHEM BIOL, V4, P329, DOI 10.1016/S1074-5521(97)90123-X
   Vernochet C, 2012, CELL METAB, V16, P765, DOI 10.1016/j.cmet.2012.10.016
   Vink AA, 1996, PHOTOCHEM PHOTOBIOL, V63, P383
   Visnes T, 2018, SCIENCE, V362, P834, DOI 10.1126/science.aar8048
   Vlahopoulos S, 2019, PHARMACOL THERAPEUT, V194, P59, DOI 10.1016/j.pharmthera.2018.09.004
   Wang W, 2011, J NEUROSCI, V31, P9746, DOI 10.1523/JNEUROSCI.0852-11.2011
   Wu JZ, 2019, CHEM RES TOXICOL, V32, P345, DOI 10.1021/acs.chemrestox.9b00046
   Wu XH, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0172092
   Xu JF, 2002, CANCER RES, V62, P2253
   Yakes FM, 1997, P NATL ACAD SCI USA, V94, P514, DOI 10.1073/pnas.94.2.514
   Yang J, 2013, NUCLEIC ACIDS RES, V41, P7240, DOI 10.1093/nar/gkt493
   Yarosh DB, 1996, PHOTOCHEM PHOTOBIOL, V63, P445, DOI 10.1111/j.1751-1097.1996.tb03067.x
   Yarosh DB, 2002, MUTAT RES-FUND MOL M, V509, P221, DOI 10.1016/S0027-5107(02)00215-4
   Yoshihara M, 2014, DNA RES, V21, P603, DOI 10.1093/dnares/dsu023
   Yu Sherry H, 2014, Adv Exp Med Biol, V810, P182
   Yuzefovych LV, 2016, CANCER RES, V76, P30, DOI 10.1158/0008-5472.CAN-15-0692
   Yuzefovych LV, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054059
   Yuzefovych LV, 2012, ENDOCRINOLOGY, V153, P92, DOI 10.1210/en.2011-1442
   Zhu J, 2018, ACS CHEM BIOL, V13, P2577, DOI 10.1021/acschembio.8b00522
NR 117
TC 44
Z9 44
U1 0
U2 26
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1568-7864
EI 1568-7856
J9 DNA REPAIR
JI DNA Repair
PD SEP
PY 2019
VL 81
SI SI
AR 102667
DI 10.1016/j.dnarep.2019.102667
PG 9
WC Genetics & Heredity; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Toxicology
GA JF3PX
UT WOS:000491300600025
PM 31311771
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kohlwein, SD
AF Kohlwein, Sepp D.
TI Obese and anorexic yeasts: Experimental models to understand the
   metabolic syndrome and lipotoxicity
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
LA English
DT Review
DE Saccharomyces cerevisiae; Schizosaccharomyces pombe; Unfolded protein
   response; TOR signaling; AMP-activated protein kinase; Apoptosis; Fatty
   acid toxicity; Lipolysis; Lipidomics
ID UNFOLDED PROTEIN RESPONSE; MG2+-DEPENDENT PHOSPHATIDATE PHOSPHATASE;
   ENDOPLASMIC-RETICULUM STRESS; POLYUNSATURATED FATTY-ACIDS;
   SACCHAROMYCES-CEREVISIAE; CELL-DEATH; FISSION YEAST; PHOSPHOLIPID
   BIOSYNTHESIS; LIPID-METABOLISM; SCHIZOSACCHAROMYCES-POMBE
AB Lipotoxicity is the pathological consequence of lipid overflow in non-adipose tissue, mediated through reactive lipid moieties which may even lead to lipid-induced cell death (lipoapoptosis). This derailment of cellular and organismal fat homeostasis is the consequence of obesity due to continued over-feeding, and contributes substantially to the pathogenesis of insulin resistance, type 2 diabetes mellitus and cardiovascular disease, which are all components of the metabolic syndrome. Now, does yeast, a single-celled eukaryote, ever suffer from the metabolic syndrome and what can we potentially learn from studies in this organism about the underlying molecular mechanism that lead to lipid-associated pathologies in human cells? In this review I will summarize the remarkably conserved metabolic and regulatory processes relevant to establishing cellular energy and lipid homeostasis, as well as recent findings that provide detailed insights into the molecular mechanisms underlying fat-induced cellular malfunction and cell death, with potential implications also for mammalian cells. (C) 2010 Elsevier B.V. All rights reserved.
C1 Graz Univ, Inst Mol Biosci, A-8010 Graz, Austria.
C3 University of Graz
RP Kohlwein, SD (corresponding author), Graz Univ, Inst Mol Biosci, Humboldtstr 50-II, A-8010 Graz, Austria.
EM sepp.kohlwein@uni-graz.at
OI Kohlwein, Sepp Dieter/0000-0002-1030-0598
FU Austrian Science Funds FWF [SFB F3005]; Austrian Federal Ministry for
   Science and Research
FX I would like to thank Klaus Natter, Oksana Tehlivets and Pamela Padilla
   for critically reading the manuscript and helpful comments. Work in our
   laboratory is supported by grants from the Austrian Science Funds FWF
   (Project SFB F3005-Lipotox and PhD program Molecular Enzymology) and the
   Austrian Federal Ministry for Science and Research (Project GOLD -
   Genomics Of Lipid-associated Disorders) in the framework of the GEN-AU
   program.
CR Alic N, 2004, FREE RADICAL BIO MED, V37, P23, DOI 10.1016/j.freeradbiomed.2004.04.014
   Athenstaedt K, 2005, J BIOL CHEM, V280, P37301, DOI 10.1074/jbc.M507261200
   Athenstaedt K, 2003, J BIOL CHEM, V278, P23317, DOI 10.1074/jbc.M302577200
   Barbet NC, 1996, MOL BIOL CELL, V7, P25, DOI 10.1091/mbc.7.1.25
   Bernales S, 2006, PLOS BIOL, V4, P2311, DOI 10.1371/journal.pbio.0040423
   Bernales S, 2006, ANNU REV CELL DEV BI, V22, P487, DOI 10.1146/annurev.cellbio.21.122303.120200
   Black PN, 2007, BBA-MOL CELL BIOL L, V1771, P286, DOI 10.1016/j.bbalip.2006.05.003
   Borradaile NM, 2006, J LIPID RES, V47, P2726, DOI 10.1194/jlr.M600299-JLR200
   Boumann HA, 2006, MOL BIOL CELL, V17, P1006, DOI 10.1091/mbc.E05-04-0344
   Brookheart RT, 2009, CELL METAB, V10, P9, DOI 10.1016/j.cmet.2009.03.011
   Carman GM, 2007, J BIOL CHEM, V282, P37293, DOI 10.1074/jbc.R700038200
   Carman GM, 2007, BBA-MOL CELL BIOL L, V1771, P239, DOI 10.1016/j.bbalip.2006.11.001
   Carman GM, 2006, TRENDS BIOCHEM SCI, V31, P694, DOI 10.1016/j.tibs.2006.10.003
   Carman GM, 1999, PROG LIPID RES, V38, P361, DOI 10.1016/S0163-7827(99)00010-7
   CARMAN GM, 1989, ANNU REV BIOCHEM, V58, P635, DOI 10.1146/annurev.biochem.58.1.635
   Chang HJ, 2004, GENETICS, V168, P1899, DOI 10.1534/genetics.104.032961
   Chang HJ, 2002, GENETICS, V162, P29
   Cipak A, 2006, FREE RADICAL BIO MED, V40, P897, DOI 10.1016/j.freeradbiomed.2005.10.039
   Cipak A, 2008, BBA-MOL CELL BIOL L, V1781, P283, DOI 10.1016/j.bbalip.2008.03.010
   Crespo JL, 2002, MICROBIOL MOL BIOL R, V66, P579, DOI 10.1128/MMBR.66.4.579-591.2002
   de Kroon AIPM, 2007, BBA-MOL CELL BIOL L, V1771, P343, DOI 10.1016/j.bbalip.2006.07.010
   Dean JT, 2009, CELL METAB, V9, P525, DOI 10.1016/j.cmet.2009.04.008
   Donkor J, 2007, J BIOL CHEM, V282, P3450, DOI 10.1074/jbc.M610745200
   Ejsing CS, 2009, P NATL ACAD SCI USA, V106, P2136, DOI 10.1073/pnas.0811700106
   Espenshade PJ, 2007, ANNU REV GENET, V41, P401, DOI 10.1146/annurev.genet.41.110306.130315
   Fabrizio P, 2001, SCIENCE, V292, P288, DOI 10.1126/science.1059497
   Farré JC, 2009, CURR OPIN CELL BIOL, V21, P522, DOI 10.1016/j.ceb.2009.04.015
   Fei WH, 2008, J CELL BIOL, V180, P473, DOI 10.1083/jcb.200711136
   Fröhlich KU, 2007, SEMIN CANCER BIOL, V17, P112, DOI 10.1016/j.semcancer.2006.11.006
   Garbarino J, 2009, J BIOL CHEM, V284, P30994, DOI 10.1074/jbc.M109.050443
   Gaspar ML, 2008, J BIOL CHEM, V283, P25735, DOI 10.1074/jbc.M802685200
   Gaspar ML, 2007, BBA-MOL CELL BIOL L, V1771, P241, DOI 10.1016/j.bbalip.2006.06.011
   Hall M N, 2008, Transplant Proc, V40, pS5, DOI 10.1016/j.transproceed.2008.10.009
   Han GS, 2006, J BIOL CHEM, V281, P9210, DOI 10.1074/jbc.M600425200
   Hardie DG, 2007, NAT REV MOL CELL BIO, V8, P774, DOI 10.1038/nrm2249
   He CC, 2009, ANNU REV GENET, V43, P67, DOI 10.1146/annurev-genet-102808-114910
   Hedbacker K, 2008, FRONT BIOSCI-LANDMRK, V13, P2408, DOI 10.2741/2854
   Heiden MGV, 2009, SCIENCE, V324, P1029, DOI 10.1126/science.1160809
   Hong SP, 2003, P NATL ACAD SCI USA, V100, P8839, DOI 10.1073/pnas.1533136100
   Hoppe T, 2000, CELL, V102, P577, DOI 10.1016/S0092-8674(00)00080-5
   Hughes AL, 2005, CELL, V120, P831, DOI 10.1016/j.cell.2005.01.012
   Jain S, 2007, J BIOL CHEM, V282, P30562, DOI 10.1074/jbc.M706326200
   Jansen M, 2009, PHYSIOL REV, V89, P777, DOI 10.1152/physrev.00026.2008
   Kanamori H, 2009, AM J PATHOL, V174, P1705, DOI 10.2353/ajpath.2009.080875
   Karaskov E, 2006, ENDOCRINOLOGY, V147, P3398, DOI 10.1210/en.2005-1494
   Kienesberger PC, 2009, J LIPID RES, V50, pS63, DOI 10.1194/jlr.R800082-JLR200
   Kohlwein SD, 2007, CURR HYPERTENS REP, V9, P455, DOI 10.1007/s11906-007-0084-5
   Kourtis N, 2009, CELL DEATH DIFFER, V16, P21, DOI 10.1038/cdd.2008.120
   Kruse KB, 2006, AUTOPHAGY, V2, P135, DOI 10.4161/auto.2.2.2388
   Kundu M, 2008, ANNU REV PATHOL-MECH, V3, P427, DOI 10.1146/annurev.pathmechdis.2.010506.091842
   Kurat CF, 2006, J BIOL CHEM, V281, P491, DOI 10.1074/jbc.M508414200
   Kurat CF, 2009, MOL CELL, V33, P53, DOI 10.1016/j.molcel.2008.12.019
   Kusminski CM, 2009, APOPTOSIS, V14, P1484, DOI 10.1007/s10495-009-0352-8
   Lingwood D, 2009, AUTOPHAGY, V5, P1039, DOI 10.4161/auto.5.7.9314
   Listenberger LL, 2001, J BIOL CHEM, V276, P14890, DOI 10.1074/jbc.M010286200
   Listenberger LL, 2002, TRENDS CARDIOVAS MED, V12, P134, DOI 10.1016/S1050-1738(02)00152-4
   Lockshon D, 2007, GENETICS, V175, P77, DOI 10.1534/genetics.106.064428
   Low CP, 2008, J CELL SCI, V121, P2671, DOI 10.1242/jcs.028977
   Low CP, 2008, BBA-MOL CELL RES, V1783, P1335, DOI 10.1016/j.bbamcr.2008.02.002
   Low CP, 2005, FEMS YEAST RES, V5, P1199, DOI 10.1016/j.femsyr.2005.07.004
   Madeo F, 2004, CURR OPIN MICROBIOL, V7, P655, DOI 10.1016/j.mib.2004.10.012
   Maedler K, 2003, DIABETES, V52, P726, DOI 10.2337/diabetes.52.3.726
   Martin CE, 2007, BBA-MOL CELL BIOL L, V1771, P271, DOI 10.1016/j.bbalip.2006.06.010
   O'Hara L, 2006, J BIOL CHEM, V281, P34537, DOI 10.1074/jbc.M606654200
   Pei LM, 2009, CELL METAB, V9, P483, DOI 10.1016/j.cmet.2009.05.006
   Peter A, 2008, AM J PHYSIOL-ENDOC M, V295, pE339, DOI 10.1152/ajpendo.00022.2008
   Petschnigg J, 2009, J BIOL CHEM, V284, P30981, DOI 10.1074/jbc.M109.024752
   Pineau L, 2009, TRAFFIC, V10, P673, DOI 10.1111/j.1600-0854.2009.00903.x
   Poli G, 2008, MED RES REV, V28, P569, DOI 10.1002/med.20117
   Reue K, 2009, CURR OPIN LIPIDOL, V20, P165, DOI 10.1097/MOL.0b013e32832adee5
   Rolland F, 2002, FEMS YEAST RES, V2, P183, DOI 10.1016/S1567-1356(02)00046-6
   Römisch K, 2005, ANNU REV CELL DEV BI, V21, P435, DOI 10.1146/annurev.cellbio.21.012704.133250
   Santos-Rosa H, 2005, EMBO J, V24, P1931, DOI 10.1038/sj.emboj.7600672
   Schaffer JE, 2003, CURR OPIN LIPIDOL, V14, P281, DOI 10.1097/00041433-200306000-00008
   Schmelzle T, 2004, MOL CELL BIOL, V24, P338, DOI 10.1128/MCB.24.1.338-351.2004
   Shirra MK, 2001, MOL CELL BIOL, V21, P5710, DOI 10.1128/MCB.21.17.5710-5722.2001
   Singh R, 2009, NATURE, V458, P1131, DOI 10.1038/nature07976
   Szymanski KM, 2007, P NATL ACAD SCI USA, V104, P20890, DOI 10.1073/pnas.0704154104
   Testerink N, 2009, J LIPID RES, V50, P2182, DOI 10.1194/jlr.M800660-JLR200
   Tong AHY, 2004, SCIENCE, V303, P808, DOI 10.1126/science.1091317
   Tong AHY, 2001, SCIENCE, V294, P2364, DOI 10.1126/science.1065810
   Towler MC, 2007, CIRC RES, V100, P328, DOI 10.1161/01.RES.0000256090.42690.05
   Turpin SM, 2006, AM J PHYSIOL-ENDOC M, V291, pE1341, DOI 10.1152/ajpendo.00095.2006
   Unger RH, 2001, DIABETES, V50, pS118, DOI 10.2337/diabetes.50.2007.S118
   Unger RH, 2002, ANNU REV MED, V53, P319, DOI 10.1146/annurev.med.53.082901.104057
   Wei M, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000467
   Wenk MR, 2005, NAT REV DRUG DISCOV, V4, P594, DOI 10.1038/nrd1776
   Wolinski H, 2009, METHODS MOL BIOL, V548, P75, DOI 10.1007/978-1-59745-540-4_5
   Wolinski H, 2009, J PROTEOME RES, V8, P20, DOI 10.1021/pr800782n
   Yan Z, 2008, NAT METHODS, V5, P719, DOI 10.1038/nmeth.1231
   Yorimitsu T, 2007, AUTOPHAGY, V3, P160, DOI 10.4161/auto.3653
   Zanghellini J, 2008, FEBS J, V275, P5552, DOI 10.1111/j.1742-4658.2008.06681.x
   Zechner R, 2009, NATURE, V458, P1118, DOI 10.1038/4581118a
   Zechner R, 2009, J LIPID RES, V50, P3, DOI 10.1194/jlr.R800031-JLR200
   Zhang Q, 2003, J BIOL CHEM, V278, P47145, DOI 10.1074/jbc.M306998200
   Zimmermann R, 2004, SCIENCE, V306, P1383, DOI 10.1126/science.1100747
   2009, METHODS MOL BIOL, P548
NR 97
TC 38
Z9 45
U1 0
U2 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1388-1981
EI 0006-3002
J9 BBA-MOL CELL BIOL L
JI Biochim. Biophys. Acta Mol. Cell Biol. Lipids
PD MAR
PY 2010
VL 1801
IS 3
SI SI
BP 222
EP 229
DI 10.1016/j.bbalip.2009.12.016
PG 8
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 568YT
UT WOS:000275563300004
PM 20056167
DA 2025-06-11
ER

PT J
AU Karakaya, P
   Ozdemir, B
   Mert, M
   Okuturlar, Y
AF Karakaya, Pinar
   Ozdemir, Bahar
   Mert, Meral
   Okuturlar, Yildiz
TI Relation of Paraoxonase 1 Activity with Biochemical Variables, Brachial
   Artery Intima-Media Thickness in Patients with Diabetes with or without
   Obesity
SO OBESITY FACTS
LA English
DT Article
DE BMI; Cardiometabolic risk; Diabetes mellitus; Obesity; Paraoxonase 1
   activity; Brachial artery intima-media thickness
ID CORONARY-HEART-DISEASE; LOW-DENSITY-LIPOPROTEIN; SERUM PARAOXONASE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; ENZYME-ACTIVITY;
   MYOCARDIAL-INFARCTION; NONDIABETIC SUBJECTS; HDL-CHOLESTEROL; MELLITUS
AB Aim: The sodium-sparing effect of insulin leads to increase in total sodium pool of the body which is a chronic stimulus for atrial natriuretic peptide (ANP). In our study we aimed to determine the relationship between ANP and microvascular complications of diabetes. Methods: 60 patients, 30-70 years old, with the diagnosis of type 2 diabetes mellitus (DM) are enrolled into the study. Patients with a chronic disease other than DM are excluded. Blood samples for routine biochemical tests are taken after at least 12 h fasting at 8-9 am. Blood samples for glucose and insulin levels are taken 2 h after a standard meal. Blood tubes with EDTA are used for ANP levels. The microvascular complications of the patients are evaluated. Results: 32 of the patients had microvascular complications. Age, BMI, waist and hip circumferences, and ANP levels were significantly higher in the group with microvascular complications. There were no significant differences in waist-to-hip ratio, blood glucose, HbA1c, fasting insulin, postprandial insulin, fasting HOMA, postprandial HOMA as well as sodium, potassium, magnesium, calcium and lipid levels between the two groups. When the relationship between ANP and obesity, retinopathy, neuropathy, nephropathy, diabetes time, HbA1c, or sex are evaluated separately, the only significant parameters related to ANP were obesity and retinopathy. Conclusion: In our study we have found that there was a significant relationship between ANP levels and microvascular complications of diabetes. Future studies are needed to show if ANP is the stimulus of microvascular complication development/progression or only an epiphenomenon. (C) 2018 The Author(s) Published by S. Karger GmbH, Freiburg
C1 [Karakaya, Pinar; Ozdemir, Bahar; Mert, Meral; Okuturlar, Yildiz] Bakirkoy Dr Sadi Konuk Training & Res Hosp, Dept Endocrinol & Metab, TR-34100 Istanbul, Turkey.
C3 Bakirkoy Dr. Sadi Konuk Research & Training Hospital
RP Karakaya, P (corresponding author), Bakirkoy Dr Sadi Konuk Training & Res Hosp, Dept Endocrinol & Metab, TR-34100 Istanbul, Turkey.
EM drpinarkarakaya@hotmail.com
RI Mert, Meral/KXR-1439-2024; Okuturlar, Yildiz/X-3647-2018
OI Mert, Meral/0000-0003-3431-0915
CR Aslan M, 2011, POL ARCH MED WEWN, V121, P181, DOI 10.20452/pamw.1051
   Ayub A, 1999, ARTERIOSCL THROM VAS, V19, P330, DOI 10.1161/01.ATV.19.2.330
   Bajnok L, 2008, ATHEROSCLEROSIS, V197, P363, DOI 10.1016/j.atherosclerosis.2007.06.001
   Bajnok L, 2007, METABOLISM, V56, P1542, DOI 10.1016/j.metabol.2007.06.022
   Beer S, 2006, NUTR METAB CARDIOVAS, V16, P457, DOI 10.1016/j.numecd.2005.09.005
   Campo S, 2004, CLIN BIOCHEM, V37, P388, DOI 10.1016/j.clinbiochem.2003.12.012
   Cao HB, 1998, ATHEROSCLEROSIS, V138, P361, DOI 10.1016/S0021-9150(98)00031-8
   Dullaart RPF, 2014, CLIN BIOCHEM, V47, P1022, DOI 10.1016/j.clinbiochem.2014.04.013
   Dullaart RPF, 2009, CLIN ENDOCRINOL, V70, P221, DOI 10.1111/j.1365-2265.2008.03306.x
   Elnoamany MF, 2012, EGYPT HEART J, V64, P55, DOI 10.1016/j.ehj.2012.01.002
   Ferré N, 2013, CLIN BIOCHEM, V46, P1830, DOI 10.1016/j.clinbiochem.2013.08.020
   Ferretti G, 2005, J CLIN ENDOCR METAB, V90, P1728, DOI 10.1210/jc.2004-0486
   Flekac M, 2008, PHYSIOL RES, V57, P717, DOI 10.33549/physiolres.931285
   Garin MCB, 2006, J LIPID RES, V47, P515, DOI 10.1194/jlr.M500281-JLR200
   Garin MCB, 2005, J CLIN ENDOCR METAB, V90, P2264, DOI 10.1210/jc.2004-1295
   Gbandjaba NY, 2012, CLIN BIOCHEM, V45, P470, DOI 10.1016/j.clinbiochem.2012.01.005
   Haffner SM, 1998, NEW ENGL J MED, V339, P229, DOI 10.1056/NEJM199807233390404
   Iwamoto Y, 2012, ARTERIOSCL THROM VAS, V32, P2295, DOI 10.1161/ATVBAHA.112.249680
   Jornayvaz FR, 2009, NUTR METAB CARDIOVAS, V19, P613, DOI 10.1016/j.numecd.2008.12.005
   Karakaya A, 1999, CHEM-BIOL INTERACT, V118, P193, DOI 10.1016/S0009-2797(99)00085-X
   Kasprzak M, 2009, CLIN BIOCHEM, V42, P50, DOI 10.1016/j.clinbiochem.2008.09.117
   Kopprasch S, 2003, J CLIN ENDOCR METAB, V88, P1711, DOI 10.1210/jc.2002-021561
   Koren-Gluzer M, 2011, ATHEROSCLEROSIS, V219, P510, DOI 10.1016/j.atherosclerosis.2011.07.119
   Kota Sunil K, 2013, Indian J Endocrinol Metab, V17, P402, DOI 10.4103/2230-8210.111618
   Kotani K, 2009, J CLIN BIOCHEM NUTR, V45, P329, DOI 10.3164/jcbn.09-26
   LADU BN, 1986, ANN BIOL CLIN-PARIS, V44, P369
   Liang KW, 2011, CLIN CHIM ACTA, V412, P1835, DOI 10.1016/j.cca.2011.06.018
   Mackness B, 1998, ATHEROSCLEROSIS, V139, P341, DOI 10.1016/S0021-9150(98)00095-1
   Mackness B, 2001, ARTERIOSCL THROM VAS, V21, P1451, DOI 10.1161/hq0901.094247
   Mackness B, 1997, ARTERIOSCL THROM VAS, V17, P1233, DOI 10.1161/01.ATV.17.7.1233
   Mackness B, 2012, DIS MARKERS, V33, P101, DOI [10.1155/2012/953768, 10.3233/DMA-2012-0910]
   MACKNESS MI, 1991, FEBS LETT, V286, P152, DOI 10.1016/0014-5793(91)80962-3
   Mackness MI, 1996, CURR OPIN LIPIDOL, V7, P69, DOI 10.1097/00041433-199604000-00004
   Pasqualini L, 2005, ATHEROSCLEROSIS, V183, P349, DOI 10.1016/j.atherosclerosis.2005.03.030
   Picard S, 1996, DIABETES METAB, V22, P25
   Rahmani M, 2002, ATHEROSCLEROSIS, V162, P381, DOI 10.1016/S0021-9150(01)00715-8
   Rosenblat M, 2006, ATHEROSCLEROSIS, V187, P74, DOI 10.1016/j.athersclerosis.2005.08.026
   Stefanovic A, 2010, CLIN BIOCHEM, V43, P1230, DOI 10.1016/j.clinbiochem.2010.08.005
   Stein JH, 2004, CLIN CARDIOL, V27, P388, DOI 10.1002/clc.4960270704
   Tabur S, 2010, EUR J ENDOCRINOL, V162, P535, DOI 10.1530/EJE-09-0732
NR 40
TC 9
Z9 9
U1 0
U2 5
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1662-4025
EI 1662-4033
J9 OBESITY FACTS
JI Obes. Facts
PY 2018
VL 11
IS 1
BP 56
EP 66
DI 10.1159/000486513
PG 11
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA FZ0TQ
UT WOS:000427286300006
PM 29439274
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lin, CP
   Lin, WT
   Leu, HB
   Wu, TC
   Chen, JW
AF Lin, CP
   Lin, WT
   Leu, HB
   Wu, TC
   Chen, JW
TI Differential mononuclear cell activity and endothelial inflammation in
   coronary artery disease and cardiac syndrome X
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE atherosclerosis; inflammation; mononuclear cell; superoxide; syndrome X
ID INTERCELLULAR-ADHESION MOLECULE-1; CYTOKINE-INDUCED EXPRESSION;
   LOW-DENSITY-LIPOPROTEIN; E-SELECTIN; OXIDATIVE STRESS; VASCULAR CELL;
   MICROVASCULAR ANGINA; HEART-DISEASE; CHEST PAIN; CAROTID ATHEROSCLEROSIS
AB Background: Circulating mononuclear cells could be activated with endothelial inflammation in patients with coronary artery disease (CAD). In some patients with normal coronary angiograms, myocardial ischemia could also present with coronary microvascular dysfunction (cardiac syndrome X). This study was undertaken to investigate whether mononuclear cell activation and endothelial inflammation can present in syndrome X patients. Methods: We evaluated the biochemical parameters, circulating soluble adhesion molecules, circulating superoxide free radicals, and mononuclear cell activity in 32 patients with syndrome X, 34 with angiographically documented CAD, and 17 age- and gender-matched healthy control subjects. Results: Compared to that in control subjects, plasma high-density lipoprotein was reduced (P<0.001) and insulin to glucose ratio increased (P=0.02) in CAD patients. Circulating level of soluble intracellular adhesion molecule-1 was significantly higher in both syndrome X and CAD patients than in control subjects (P<0.01), whereas the levels of soluble vascular cell adhesion molecule (P=0.02) and von Willebrand factor (P=0.01) were increased in CAD patients only. The peak (P<0.001) and total counts of superoxide free radicals in whole blood (P<0.001) was significantly higher in syndrome X patients than in the other two groups. However, phorbol-12-myristate-13-acetate-induced superoxide free radical generation of mononuclear cells was increased in CAD (10.5+/-4.6%, P=0.01) but not in syndrome X patients (8.7+/-2.0%) as compared with control subjects (7.7+/-0.5%). Conclusions: The results indicated that the activity of mononuclear cells was increased with significant endothelial inflammation and injury in CAD patients. In syndrome X patients, though circulating superoxide free radicals were increased, there was minimal endothelial inflammation without mononuclear cell activation. The relatively preserved lipid and metabolic profiles might contribute to less vascular inflammation in syndrome X patients. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
C1 Taipei Vet Gen Hosp, Dept Pathol, Taipei 11217, Taiwan.
   Vet Gen Hosp, Dept Internal Med, Div Cardiol, Taipei 11217, Taiwan.
   Natl Yang Ming Univ, Sch Med, Cardiovasc Res Ctr, Taipei 11217, Taiwan.
C3 Taipei Veterans General Hospital; National Yang Ming Chiao Tung
   University
RP Chen, JW (corresponding author), Taipei Vet Gen Hosp, Dept Pathol, 201 Sect 2 Shih Pai Rd, Taipei 11217, Taiwan.
CR Aukrust P, 2001, J AM COLL CARDIOL, V37, P485, DOI 10.1016/S0735-1097(00)01110-4
   Balbay Y, 2001, ANGIOLOGY, V52, P109, DOI 10.1177/000331970105200204
   Bellamy MF, 1998, CARDIOVASC RES, V40, P410, DOI 10.1016/S0008-6363(98)00184-9
   Bradford, 1999, J INTEGRATIVE MED, V1, P73
   CANNON RO, 1988, AM J CARDIOL, V61, P1338, DOI 10.1016/0002-9149(88)91180-0
   Chen JW, 1996, JPN HEART J, V37, P865
   Chen JW, 1997, AM J CARDIOL, V80, P32
   COCKERILL GW, 1995, ARTERIOSCL THROM VAS, V15, P1987, DOI 10.1161/01.ATV.15.11.1987
   Cockerill GW, 1999, ARTERIOSCL THROM VAS, V19, P910, DOI 10.1161/01.ATV.19.4.910
   DAVIES B, 1992, J BIOLUM CHEMILUM, V7, P229, DOI 10.1002/bio.1170070402
   de Lemos JA, 2000, J AM COLL CARDIOL, V36, P423, DOI 10.1016/S0735-1097(00)00742-7
   Desideri G, 2000, CIRCULATION, V102, P2359, DOI 10.1161/01.CIR.102.19.2359
   DUBOISRANDE JL, 1994, EUR HEART J, V15, P179, DOI 10.1093/oxfordjournals.eurheartj.a060473
   Feillet-Coudray C, 1999, FREE RADICAL BIO MED, V27, P463, DOI 10.1016/S0891-5849(99)00096-9
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Frijns CJM, 1997, STROKE, V28, P2214, DOI 10.1161/01.STR.28.11.2214
   HARRISON DG, 1995, AM J CARDIOL, V75, P75
   Huo Y, 2001, ACTA PHYSIOL SCAND, V173, P35, DOI 10.1046/j.1365-201X.2001.00882.x
   Hwang SJ, 1997, CIRCULATION, V96, P4219
   Iiyama K, 1999, CIRC RES, V85, P199, DOI 10.1161/01.RES.85.2.199
   Ikeda U, 1998, CLIN CARDIOL, V21, P11, DOI 10.1002/clc.4960210103
   KASKI JC, 1995, J AM COLL CARDIOL, V25, P807, DOI 10.1016/0735-1097(94)00507-M
   LEATHAM EW, 1995, BRIT HEART J, V73, P10
   Lee WH, 1999, EXP MOL MED, V31, P159, DOI 10.1038/emm.1999.26
   LITCHTLEN PR, 1995, J AM COLL CARDIOL, V25, P1013
   LIU TZ, 2000, J BIOMED LAB SCI, V12, P62
   Matsumoto K, 2000, ATHEROSCLEROSIS, V152, P415, DOI 10.1016/S0021-9150(99)00487-6
   Mercuri F, 2000, Diabetes Technol Ther, V2, P589, DOI 10.1089/15209150050502014
   O'Malley T, 2001, EUR HEART J, V22, P1226, DOI 10.1053/euhj.2000.2480
   OBrien KD, 1996, CIRCULATION, V93, P672, DOI 10.1161/01.CIR.93.4.672
   Paolisso G, 1999, DIABETES METAB, V25, P298
   Petzke KJ, 2000, J NUTR, V130, P2889, DOI 10.1093/jn/130.12.2889
   PRONAI L, 1991, ATHEROSCLEROSIS, V90, P39, DOI 10.1016/0021-9150(91)90242-U
   RADICE M, 1994, AM J CARDIOL, V73, P968, DOI 10.1016/0002-9149(94)90143-0
   Sanderson JE, 1997, CARDIOLOGY, V88, P414, DOI 10.1159/000177370
   Seljeflot I, 2002, ATHEROSCLEROSIS, V162, P179, DOI 10.1016/S0021-9150(01)00696-7
   Semaan HB, 2000, CARDIOLOGY, V93, P7, DOI 10.1159/000006995
   Siminiak T, 1999, CORONARY ARTERY DIS, V10, P235, DOI 10.1097/00019501-199906000-00005
   Storz G, 1999, CURR OPIN MICROBIOL, V2, P188, DOI 10.1016/S1369-5274(99)80033-2
   Tardif JC, 1997, NEW ENGL J MED, V337, P365, DOI 10.1056/NEJM199708073370601
   Tousoulis D, 2001, CLIN CARDIOL, V24, P301, DOI 10.1002/clc.4960240409
   TSAI CH, 2000, J BIOMEDICAL LAB SCI, V12, P107
   Tselepis AD, 1996, EUR J CLIN INVEST, V26, P1150, DOI 10.1046/j.1365-2362.1996.520609.x
   Vogel RA, 1997, CLIN CARDIOL, V20, P426, DOI 10.1002/clc.4960200505
   Wallén NH, 1999, EUR HEART J, V20, P1039
   Watson AD, 1995, J CLIN INVEST, V96, P2882, DOI 10.1172/JCI118359
NR 46
TC 40
Z9 42
U1 0
U2 3
PU ELSEVIER SCI IRELAND LTD
PI CLARE
PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE,
   IRELAND
SN 0167-5273
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD MAY
PY 2003
VL 89
IS 1
BP 53
EP 62
DI 10.1016/S0167-5273(02)00428-X
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 683TL
UT WOS:000183165700006
PM 12727005
DA 2025-06-11
ER

PT J
AU Miler, M
   Nikolac, N
   Segulja, D
   Maslac, SK
   Celap, I
   Altabas, K
   Sefer, S
   Simundic, AM
AF Miler, M.
   Nikolac, N.
   Segulja, D.
   Maslac, S. Kackov
   Celap, I.
   Altabas, K.
   Sefer, S.
   Simundic, A. M.
TI Is peritoneal dialysis causing a measurable burden of inflammatory and
   endothelial injury on top of metabolic syndrome?
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE Adipokines; Endothelial impairment; Inflammation; Metabolic syndrome;
   Oxidative stress; Peritoneal dialysis
ID CHRONIC KIDNEY-DISEASE; VISFATIN; ASSOCIATION; DYSFUNCTION; MARKERS;
   LIGAND; RISK
AB Purpose Low-grade chronic inflammation is present in patients on peritoneal dialysis (PD) and in metabolic syndrome (MS). Due to possible greater endothelial changes in dialyzed patients, inflammatory response and oxidative stress are probably stronger in patients on PD. The objective of the study was to investigate possible in between adipokines, inflammatory, endothelial and oxidative stress markers between MS patients and patients on PD.
   Methods Concentrations of adipokines (leptin, resistin), inflammatory markers [interleukin-6 (IL-6), soluble tumor necrosis factor alpha receptor (sTNF-R), myeloperoxidase (MPO), monocyte chemoattractant protein 1 (MCP-1)] and endothelial markers [soluble intracellular adhesion molecule- 1 (sICAM-1), soluble CD40 ligand (sCD40L)] were determined in 55 MS patients and 18 patients on PD, with flow cytometry, and visfatin concentration was measured with ELISA. Routine biochemistry parameters were measured on Beckman Coulter AU2700 analyzer.
   Results Patients on PD have significantly higher concentration of: CRP [6.5 (3.7-12.1) versus 2.6 (1.3-4.0) mg/L, P < 0.001], IL- 6 [13.83 (8.48- 31.31) versus 2.05 (0.67-4.11) pg/mL, P < 0.001], MCP- 1 [2172.28 (1563.84-2922.77) versus 1353.58 (1166.33-1961.70) pg/mL, P = 0.023], sTNF-R [18.25 (12.81-25.22) versus 1.23 (0.89-1.43) ng/mL, P < 0.001] and sICAM-1 [830.03 (599.21-967.02) versus 463.85 (315.25-751.71) ng/mL, P = 0.006] than subjects with MS. MS patients have higher concentrations of MPO [175.47 (120.15-231.67) versus 101.76 (53.55-186.06) ng/mL, P = 0.016] and visfatin [1.5 (0.9-2.3) versus 0.9 (0.6-1.6) ng/mL, P = 0.013].
   Conclusion In patients on PD, inflammatory reaction is higher than in patients with MS. On the contrary, patients with MS have stronger oxidative stress response and adipose tissue activity caused probably by the chronic low level of inflammation and underlying metabolic disorders.
C1 [Miler, M.; Nikolac, N.; Celap, I.] Univ Hosp, Sestre Milosrdnice Med Sch, Univ Dept Chem, Zagreb, Croatia.
   [Segulja, D.] Univ Hosp Ctr Zagreb, Dept Lab Diagnost, Zagreb, Croatia.
   [Maslac, S. Kackov] Policlin Bonifarm, Med Biochem Lab, Zagreb, Croatia.
   [Altabas, K.; Sefer, S.] Univ Hosp Sestre Milosrdnice, Sch Med, Dept Nephrol & Dialysis, Zagreb, Croatia.
   [Simundic, A. M.] Univ Hosp Sveti Duh, Dept Med Lab Diagnost, Zagreb, Croatia.
C3 University of Zagreb; UNIVERSITY ZAGREB HOSPITAL; University of Zagreb
RP Miler, M (corresponding author), Univ Hosp, Sestre Milosrdnice Med Sch, Univ Dept Chem, Zagreb, Croatia.
EM marijana.miler@gmail.com
RI Celap, Ivana/D-1964-2017
OI Celap, Ivana/0000-0002-3982-5777
FU Ministry of Science, Education and Sports, Republic of Croatia
   [134-1340227-0200]
FX This study was supported by Ministry of Science, Education and Sports,
   Republic of Croatia, project Number: 134-1340227-0200.
CR [Anonymous], HARRISONS NEPHROLOGY
   [Anonymous], OXID MED CELL LONGEV
   Biljak VR, 2015, BIOCHEM MEDICA, V25, P73, DOI 10.11613/BM.2015.009
   Carrero JJ, 2009, CLIN J AM SOC NEPHRO, V4, pS49, DOI 10.2215/CJN.02720409
   Celap I, 2013, CLIN LAB, V59, P1253, DOI 10.7754/Clin.Lab.2013.121036
   El-Shahhat N, 2011, EGYPT HEART J, V63, P131, DOI 10.1016/j.ehj.2011.08.024
   Emanuela F, 2012, J NUTR METAB, V2012, DOI 10.1155/2012/476380
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Halcox JPJ, 2014, J DIABETES METAB, V5, DOI 10.4172/2155-6156.1000362
   Hopps E, 2010, NUTR METAB CARDIOVAS, V20, P72, DOI 10.1016/j.numecd.2009.06.002
   Hosseinzadeh-Attar MJ, 2016, J ENDOCRINOL INVEST, V39, P917, DOI 10.1007/s40618-016-0457-1
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kidney Disease, 2013, Kidney Int Suppl, V3, P1, DOI DOI 10.1038/KISUP.2012.73
   Loughrey BV, 2013, CLIN ENDOCRINOL, V79, P800, DOI 10.1111/cen.12113
   Mehrotra R, 2013, CURR OPIN NEPHROL HY, V22, P663, DOI 10.1097/MNH.0b013e328365b3d1
   Neirynck N, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0122073
   Nishimura Satoshi, 2009, Discov Med, V8, P55
   Olszanecka-Glinianowicz M, 2011, KARDIOL POL, V69, P802
   Park SH, 2012, NEPHROL DIAL TRANSPL, V27, P1191, DOI 10.1093/ndt/gfr451
   Sikorska D, 2016, CYTOKINE, V85, P171, DOI 10.1016/j.cyto.2016.06.005
   Velloso MSS, 2014, CLIN CHIM ACTA, V430, P109, DOI 10.1016/j.cca.2013.12.003
   Tucker PS, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/806358
   Tung CW, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0141058
   Wang Angela Y-M, 2005, Curr Opin Investig Drugs, V6, P879
   World Health Organization, 2011, Waist circumference and waist-hip ratio: report of a WHO expert consultation
   Wu CL, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0109558
   Yegin ZA, 2015, J ENDOCRINOL INVEST, V38, P333, DOI 10.1007/s40618-014-0174-6
   Zhao LQ, 2010, INVEST OPHTH VIS SCI, V51, P4652, DOI 10.1167/iovs.09-3789
NR 28
TC 5
Z9 5
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0391-4097
EI 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD FEB
PY 2017
VL 40
IS 2
BP 163
EP 168
DI 10.1007/s40618-016-0540-7
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EO7OR
UT WOS:000396880500006
PM 27600388
DA 2025-06-11
ER

PT J
AU Gounden, V
   Devaraj, S
   Jialal, I
AF Gounden, Verena
   Devaraj, Sridevi
   Jialal, Ishwarlal
TI The role of the triglyceride-glucose index as a biomarker of
   cardio-metabolic syndromes
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Review
DE Triglyceride-glucose index; Cardiovascular disease; Metabolic syndrome;
   Insulin resistance; Diabetes
ID TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   TYG INDEX; EVENTS; RISK; PRODUCT; HOMA
AB BackgroundThe Triglyceride-glucose (TyG) index represents a simple, cost-effective, and valid proxy for insulin resistance. This surrogate marker has also been proposed as a predictor of metabolic and cardiovascular disease (CVD). In this descriptive review, we aimed to assess the utility of the TyG index as a predictive biomarker of cardiometabolic diseases.MethodsA search was conducted in PubMed, and Web of Science to identify cross-sectional and more importantly prospective studies examining the use of the TyG index as a predictive biomarker. The following terms were utilized in addition to the TyG index: "insulin resistance", "metabolic syndrome", "diabetes"; "cardiovascular diseases".ResultsThis descriptive review included thirty prospective studies in addition to cross-sectional studies. Following adjustment for confounding variables, an elevated TyG index was associated with a significantly increased risk for the development of Metabolic Syndrome (MetS), Type 2 Diabetes, hypertension, and CVD. Also in limited studies, the TyG index was associated with endothelial dysfunction, increased oxidative stress and a pro-inflammatory phenotype.ConclusionOverall, our findings support the use of the TyG index as a valid biomarker to assess the risk of developing MetS, T2DM, as well as atherosclerotic cardiovascular disease.
C1 [Gounden, Verena] Univ Hosp Galway, Dept Clin Biochem, Galway H91YR71, Ireland.
   [Devaraj, Sridevi] Baylor Coll Med, Houston, TX USA.
   [Jialal, Ishwarlal] UC Davis Sch Med, Internal Med & Pathol, 2616 Hepworth Dr, Davis, CA 95618 USA.
C3 Baylor College of Medicine; University of California System; University
   of California Davis
RP Jialal, I (corresponding author), UC Davis Sch Med, Internal Med & Pathol, 2616 Hepworth Dr, Davis, CA 95618 USA.
EM kjialal@gmail.com
CR Abel ED, 2012, ARTERIOSCL THROM VAS, V32, P2068, DOI 10.1161/ATVBAHA.111.241984
   Abuduaini B, 2023, DIABET METAB SYND OB, V16, P1093, DOI 10.2147/DMSO.S408766
   Adams-Huet B, 2024, J CLIN MED, V13, DOI 10.3390/jcm13133941
   Adams-Huet B, 2024, J CLIN LIPIDOL, V18, pe518, DOI 10.1016/j.jacl.2024.04.130
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alizargar J, 2020, J PEDIATR ENDOCR MET, V33, P945, DOI 10.1515/jpem-2019-0579
   Amer Diabet Assoc, 2021, DIABETES CARE, V44, pS200, DOI 10.2337/dc21-S014
   Avagimyan A, 2025, INT J CARDIOL, V418, DOI 10.1016/j.ijcard.2024.132663
   Bae JH, 2020, DIABETES METAB J, V44, P458, DOI 10.4093/dmj.2019.0061
   Caturano A, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25158369
   Chamroonkiadtikun P, 2020, PRIM CARE DIABETES, V14, P161, DOI 10.1016/j.pcd.2019.08.004
   Che BZ, 2023, CARDIOVASC DIABETOL, V22, DOI 10.1186/s12933-023-01762-2
   D'elia L, 2024, MINERVA MED, DOI 10.23736/S0026-4806.24.09155-9
   da Silva A, 2020, PRIM CARE DIABETES, V14, P584, DOI 10.1016/j.pcd.2020.09.001
   DeFronzo RA, 2010, DIABETOLOGIA, V53, P1270, DOI 10.1007/s00125-010-1684-1
   Demirci I, 2023, ARCH ENDOCRIN METAB, V67, P378, DOI 10.20945/2359-3997000000594
   Deng H, 2022, CARDIOVASC DIABETOL, V21, DOI 10.1186/s12933-022-01660-z
   Diabetes Atlas, Website IDF
   Fu XM, 2022, FRONT PUBLIC HEALTH, V9, DOI 10.3389/fpubh.2021.796663
   Gao Y, 2024, CARDIOVASC DIABETOL, V23, DOI 10.1186/s12933-024-02484-9
   Gao YM, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1150980
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Guerrero-Romero F, 2016, ARCH MED RES, V47, P382, DOI 10.1016/j.arcmed.2016.08.012
   Guerrero-Romero F, 2010, J CLIN ENDOCR METAB, V95, P3347, DOI 10.1210/jc.2010-0288
   Guo YF, 2024, LIPIDS HEALTH DIS, V23, DOI 10.1186/s12944-024-02076-2
   Harper SC, 2016, CIRC RES, V118, P1143, DOI 10.1161/CIRCRESAHA.116.306206
   Huang RH, 2022, EUR J PREV CARDIOL, V29, P1531, DOI 10.1093/eurjpc/zwac058
   Jialal I, 2025, METAB SYNDR RELAT D, V23, P135, DOI 10.1089/met.2024.0193
   Vasques ACJ, 2011, DIABETES RES CLIN PR, V93, pE98, DOI 10.1016/j.diabres.2011.05.030
   Kang SW, 2023, MOL CELL BIOCHEM, V478, P39, DOI 10.1007/s11010-022-04494-1
   Kassab HS, 2023, ENDOCR RES, V48, P94, DOI 10.1080/07435800.2023.2245909
   Köktürk U, 2024, NUTR METAB CARDIOVAS, V34, P860, DOI 10.1016/j.numecd.2023.12.025
   Kosmas CE, 2023, J INT MED RES, V51, DOI 10.1177/03000605231164548
   Kurniawan Liong Boy, 2024, EJIFCC, V35, P44
   Lee DY, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0163465
   Li HB, 2022, CARDIOVASC DIABETOL, V21, DOI 10.1186/s12933-022-01541-5
   Li TY, 2023, NUTRIENTS, V15, DOI 10.3390/nu15122808
   Li XL, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-01403-7
   Li Y, 2024, ENDOCRINE, V85, P717, DOI 10.1007/s12020-024-03785-5
   Lindstrom M, 2022, J AM COLL CARDIOL, V80, P2372, DOI 10.1016/j.jacc.2022.11.001
   Liu X, 2023, CARDIOVASC DIABETOL, V22, DOI 10.1186/s12933-023-01777-9
   Liu YS, 2021, ENDOCR CONNECT, V10, P1420, DOI 10.1530/EC-21-0234
   Lopez-Jaramillo P, 2023, LANCET HEALTH LONGEV, V4, pE23, DOI 10.1016/S2666-7568(22)00247-1
   Low S, 2018, DIABETES RES CLIN PR, V143, P43, DOI 10.1016/j.diabres.2018.06.006
   Moon JH, 2023, ENDOCRINOL METAB, V38, P406, DOI 10.3803/EnM.2023.1703
   Nabipoorashra SA, 2022, NUTR METAB CARDIOVAS, V32, P2677, DOI 10.1016/j.numecd.2022.07.024
   Nyström PK, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0127111
   Ormazabal V, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0762-4
   Pahwa R, 2024, StatPearls Internet
   Pan Y, 2024, DIABET METAB SYND OB, V17, P3325, DOI 10.2147/DMSO.S478287
   Pang J, 2023, CLIN EXP HYPERTENS, V45, DOI 10.1080/10641963.2023.2272581
   Park B, 2020, CARDIOVASC DIABETOL, V19, DOI 10.1186/s12933-020-01186-2
   Park B, 2021, TRANSL RES, V228, P42, DOI 10.1016/j.trsl.2020.08.003
   Rafiee H, 2024, EUR J MED RES, V29, DOI 10.1186/s40001-024-01728-4
   REAVEN GM, 1993, ANNU REV MED, V44, P121, DOI 10.1146/annurev.med.44.1.121
   Rong LJ, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1191090
   Rout A, 2024, HEART, V110, P1005, DOI 10.1136/heartjnl-2023-322928
   Sánchez-García A, 2020, INT J ENDOCRINOL, V2020, DOI 10.1155/2020/4678526
   Sánchez-Iñigo L, 2016, EUR J CLIN INVEST, V46, P189, DOI 10.1111/eci.12583
   Saotome M, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20143552
   Simental-Mendía LE, 2020, EUR J PEDIATR, V179, P1171, DOI 10.1007/s00431-020-03644-1
   Simental-Mendia Luis E., 2008, Metabolic Syndrome and Related Disorders, V6, P299, DOI 10.1089/met.2008.0034
   Son DH, 2022, NUTR METAB CARDIOVAS, V32, P596, DOI 10.1016/j.numecd.2021.11.017
   Tao LC, 2022, CARDIOVASC DIABETOL, V21, DOI 10.1186/s12933-022-01511-x
   Tian X, 2021, CARDIOVASC DIABETOL, V20, DOI 10.1186/s12933-020-01210-5
   Wallace TM, 2004, DIABETES CARE, V27, P1487, DOI 10.2337/diacare.27.6.1487
   Wan YM, 2023, DIABETOL METAB SYNDR, V15, DOI 10.1186/s13098-023-01181-z
   Wang L, 2020, CARDIOVASC DIABETOL, V19, DOI 10.1186/s12933-020-01054-z
   Wang ZQ, 2021, ENDOCRINE, V72, P124, DOI 10.1007/s12020-020-02589-7
   Xin FL, 2023, CARDIOVASC DIABETOL, V22, DOI 10.1186/s12933-023-02087-w
   Yan Y, 2022, CARDIOVASC DIABETOL, V21, DOI 10.1186/s12933-022-01453-4
   Yang CQ, 2024, J CLIN HYPERTENS, V26, P53, DOI 10.1111/jch.14758
   Yang M, 2024, FRONT ENDOCRINOL, V15, DOI 10.3389/fendo.2024.1452896
   Yao HP, 2022, DIABET METAB SYND OB, V15, P3483, DOI 10.2147/DMSO.S387040
   Yao YN, 2024, CARDIOVASC DIABETOL, V23, DOI 10.1186/s12933-024-02120-6
   Yin CH, 2024, INT HEART J, V65, P373, DOI 10.1536/ihj.23-413
   Zeng XH, 2022, FRONT CARDIOVASC MED, V9, DOI 10.3389/fcvm.2022.944258
   Zeng Y, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1241372
   Zhang FD, 2024, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1322445
   Zhang Q, 2023, CARDIOVASC DIABETOL, V22, DOI 10.1186/s12933-023-02030-z
   Zheng RJ, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0562-y
   Zhou D, 2022, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.778038
   Zhou JL, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1302127
   Zhou Q, 2023, CARDIOVASC DIABETOL, V22, DOI 10.1186/s12933-023-02001-4
NR 84
TC 6
Z9 6
U1 6
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD DEC 23
PY 2024
VL 23
IS 1
AR 416
DI 10.1186/s12944-024-02412-6
PG 13
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA Q1Y6L
UT WOS:001382728100001
PM 39716258
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Schiano, C
   Grimaldi, V
   Scognamiglio, M
   Costa, D
   Soricelli, A
   Nicoletti, GF
   Napoli, C
AF Schiano, Concetta
   Grimaldi, Vincenzo
   Scognamiglio, Michele
   Costa, Dario
   Soricelli, Andrea
   Nicoletti, Giovanni Francesco
   Napoli, Claudio
TI Soft drinks and sweeteners intake: Possible contribution to the
   development of metabolic syndrome and cardiovascular diseases.
   Beneficial or detrimental action of alternative sweeteners?
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Review
DE Cardiovascular disease; Metabolic syndrome; Nutrition; Soft drink;
   Alternative sweetener
AB The rapid increase in obesity, metabolic syndrome, and cardiovascular diseases (CVDs) has been related to the rise in sugar-added foods and sweetened beverages consumption. An interesting approach has been to replace sugar with alternative sweeteners (AS), due to their impact on public health. Preclinical and clinical studies, which analyze the safety of AS intake, are still limited. Major pathogenic mechanisms of these substances include ROS and AGEs formation. Indeed, endothelial dysfunction involving in the pathogenesis of micro-and macro-vascular diseases is mitochondrial dysfunction dependent. Hyperglycemia and endoplasmic reticulum stress together produce ROS, contributing to the development and progression of cardiovascular complications during type 2 diabetes (T2D), thus causing oxidative changes and direct damage of lipids, proteins, and DNA. Epide-miological studies in healthy subjects have suggested that the consumption of artificial AS can promote CV complications, such as glucose intolerance and predisposition to the onset of T2D, whereas natural AS could reduce hyperglycemia, improve lipid metabolism and have antioxidant effects. Long-term prospective clinical randomized studies are needed to evaluate precisely whether exposure to alternative sugars can have clinical implications on natural history and clinical outcomes, especially in children or during the gestational period through breast milk.
C1 [Schiano, Concetta; Napoli, Claudio] Univ Campania L Vanvitelli, Dept Adv Med & Surg Sci DAMSS, Naples, Italy.
   [Grimaldi, Vincenzo; Soricelli, Andrea; Napoli, Claudio] IRCCS SDN, Naples, Italy.
   [Scognamiglio, Michele; Costa, Dario; Napoli, Claudio] Azienda Univ Policlin AOU, Clin Dept Internal Med & Specialist Units, Div Clin Immunol & Irumunohernatol Transfus Med &, Reg Reference Lab Transplant Immunol LIT, Naples, Italy.
   [Soricelli, Andrea] Univ Naples Parthenope, Dept Exercise & Wellness Sci, Naples, Italy.
   [Nicoletti, Giovanni Francesco] Univ Campania L Vanvitelli, Multidisciplinary Dept Med Surg & Dent Sci, Plast Surg Unit, Naples, Italy.
C3 Universita della Campania Vanvitelli; IRCCS Istituto di Ricerca
   Diagnostica e Nucleare (SDN); Parthenope University Naples; Universita
   della Campania Vanvitelli
RP Schiano, C (corresponding author), Univ Campania L Vanvitelli, Dept Adv Med & Surg Sci, I-80138 Naples, Italy.
EM concetta.schiano@unicampania.it
RI soricelli, andrea/C-1133-2009; Schiano, Concetta/GOE-4310-2022
FU National Research Competitive Grant (PRIN) from Ministery for University
   and Research, Italy [F8ZB89]; MUR Italy; Ministery of Health, Italy
   [GR-2016-02362046]; PON-AIM of the Ministery for University and
   Research, Italy
FX This review was funded by National Research Competitive Grant (PRIN
   supporting grant no. F8ZB89) from Ministery for University and Research,
   Italy (to Professor Claudio Napoli, M.D., Ph.D.); by Research
   Competitive Grant "VALERE:2020" (to Dr. Schiano Concetta, Ph.D.) from
   MUR Italy; by National Research Competitive Grant GR-2016-02362046 (to
   Dr. Vincenzo Grimaldi, Ph.D.) from Ministery of Health, Italy. The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript. CS, Pharm.D,
   Ph.D. is a Researcher type A supported by PON-AIM of the Ministery for
   University and Research, Italy.
CR Abou-Donia MB, 2008, J TOXICOL ENV HEAL A, V71, P1415, DOI 10.1080/15287390802328630
   Aguilar F, 2014, EFSA J, V12, DOI 10.2903/j.efsa.2014.3639
   Al Humaid J, 2018, INT J HEALTH SCI-IJH, V12, P75
   Amin KA, 2015, INT J CLIN EXP MED, V8, P6133
   Anderson CA, 2009, OBES REV, V10, P41, DOI 10.1111/j.1467-789X.2008.00564.x
   Andrejic BM, 2013, BOSNIAN J BASIC MED, V13, P94
   Anton SD, 2010, APPETITE, V55, P37, DOI 10.1016/j.appet.2010.03.009
   Azeez OH, 2019, MEDICINA-LITHUANIA, V55, DOI 10.3390/medicina55100681
   Banga S, 2020, J AM COLL NUTR, V39, P272, DOI 10.1080/07315724.2019.1642811
   Bartel DP, 2004, CELL, V116, P281, DOI 10.1016/S0092-8674(04)00045-5
   Basílio M, 2020, FOOD ADDIT CONTAM A, V37, P2040, DOI 10.1080/19440049.2020.1812734
   Bellier J, 2019, DIABETES RES CLIN PR, V148, P200, DOI 10.1016/j.diabres.2019.01.002
   Bellisle F, 2007, EUR J CLIN NUTR, V61, P691, DOI 10.1038/sj.ejcn.1602649
   Berry C, 2016, NUTR CANCER, V68, P1247, DOI 10.1080/01635581.2016.1224366
   Bian XM, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0178426
   Bibbò S, 2017, ANN MED, V49, P11, DOI 10.1080/07853890.2016.1222449
   Brambilla E, 2014, CARIES RES, V48, P19, DOI 10.1159/000351650
   Brandle JE, 2007, PHYTOCHEMISTRY, V68, P1855, DOI 10.1016/j.phytochem.2007.02.010
   Bray GA, 2014, DIABETES CARE, V37, P950, DOI 10.2337/dc13-2085
   Burke MV, 2015, PHYSIOL BEHAV, V152, P381, DOI 10.1016/j.physbeh.2015.05.036
   Cani PD, 2013, CURR OPIN PHARMACOL, V13, P935, DOI 10.1016/j.coph.2013.09.008
   Cantoral A, 2016, PEDIATR OBES, V11, P68, DOI 10.1111/ijpo.12023
   Carwile JL, 2015, HUM REPROD, V30, P675, DOI 10.1093/humrep/deu349
   Castaner O, 2018, INT J ENDOCRINOL, V2018, DOI 10.1155/2018/4095789
   Chattopadhyay S, 2014, J FOOD SCI TECH MYS, V51, P611, DOI 10.1007/s13197-011-0571-1
   Choy CC, 2018, PUBLIC HEALTH NUTR, V21, P1243, DOI 10.1017/S1368980017003913
   Costa D, 2019, BIOGERONTOLOGY, V20, P605, DOI 10.1007/s10522-019-09824-3
   Crismaru I, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-01275-x
   Daly K, 2016, PHYSIOL BEHAV, V164, P494, DOI 10.1016/j.physbeh.2016.03.014
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   de Oliveira DN, 2015, SCI REP-UK, V5, DOI 10.1038/srep09598
   de Ruyter JC, 2012, NEW ENGL J MED, V367, P1397, DOI 10.1056/NEJMoa1203034
   Della Torre SB, 2016, J ACAD NUTR DIET, V116, P638, DOI 10.1016/j.jand.2015.05.020
   Agüero SD, 2018, BIOMED RES INT, V2018, DOI 10.1155/2018/4806534
   Ebbeling CB, 2012, NEW ENGL J MED, V367, P1407, DOI 10.1056/NEJMoa1203388
   Eisenreich A, 2020, FOOD CHEM, V321, DOI 10.1016/j.foodchem.2020.126700
   Eny KM, 2020, PREV MED REP, V17, DOI 10.1016/j.pmedr.2020.101054
   Evans JMM, 2002, BRIT MED J, V324, P939, DOI 10.1136/bmj.324.7343.939
   Fabiano V, 2020, MINERVA PEDIATR, V72, P182, DOI 10.23736/S0026-4946.20.05803-X
   Farhat G, 2019, NUTRIENTS, V11, DOI 10.3390/nu11123036
   Fitch C, 2012, J ACAD NUTR DIET, V112, P739, DOI 10.1016/j.jand.2012.03.009
   Foreyt J, 2012, J NUTR, V142, p1155S, DOI 10.3945/jn.111.149609
   Forshee RA, 2003, INT J FOOD SCI NUTR, V54, P297, DOI [10.1080/09637480120092143, 10.1080/096374803766666175]
   Fowler SPG, 2016, PHYSIOL BEHAV, V164, P517, DOI 10.1016/j.physbeh.2016.04.047
   Frank GKW, 2008, NEUROIMAGE, V39, P1559, DOI 10.1016/j.neuroimage.2007.10.061
   Gardener H, 2018, CURR DEV NUTR, V2, DOI 10.1093/cdn/nzy008
   Geuns JMC, 2003, PHYTOCHEMISTRY, V64, P913, DOI 10.1016/S0031-9422(03)00426-6
   Gil-Campos M, 2015, An Pediatr (Barc), V83, DOI 10.1016/j.anpedi.2015.02.013
   Goyal SK, 2010, INT J FOOD SCI NUTR, V61, P1, DOI 10.3109/09637480903193049
   Green CH, 2019, EUR J NUTR, V58, P1785, DOI 10.1007/s00394-019-01996-5
   Greenwood DC, 2014, BRIT J NUTR, V112, P725, DOI 10.1017/S0007114514001329
   Grembecka M, 2015, EUR FOOD RES TECHNOL, V241, P1, DOI 10.1007/s00217-015-2437-7
   Grotz VL, 2008, HEADACHE, V48, P164, DOI 10.1111/j.1526-4610.2007.00983.x
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Gupta Megha, 2018, Open Access Maced J Med Sci, V6, P1888, DOI 10.3889/oamjms.2018.336
   Gupta Prahlad, 2013, ISRN Dent, V2013, P519421, DOI 10.1155/2013/519421
   Hess EL, 2018, J AM COLL NUTR, V37, P487, DOI 10.1080/07315724.2018.1440658
   Hill JO, 2012, CIRCULATION, V126, P126, DOI 10.1161/CIRCULATIONAHA.111.087213
   HORWITZ DL, 1988, DIABETES CARE, V11, P230, DOI 10.2337/diacare.11.3.230
   Hunter SR, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112717
   Huth PJ, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-116
   Huvaere K, 2012, FOOD ADDIT CONTAM A, V29, P54, DOI 10.1080/19440049.2011.627572
   Imamura F, 2016, BRIT J SPORT MED, V50, P496, DOI 10.1136/bjsports-2016-h3576rep
   Jansen F, 2013, CIRCULATION, V128, P2026, DOI 10.1161/CIRCULATIONAHA.113.001720
   Ruiz-Ojeda FJ, 2019, ADV NUTR, V10, pS31, DOI 10.1093/advances/nmy037
   Jensen PN, 2020, EUR J CLIN NUTR, V74, P322, DOI 10.1038/s41430-019-0461-6
   Kajikawa M, 2015, DIABETES CARE, V38, P119, DOI 10.2337/dc14-1435
   Katan MB, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0159771
   Kim M, 2017, FOOD ADDIT CONTAM A, V34, P1500, DOI 10.1080/19440049.2017.1349344
   Kim Y, 2019, CURR ATHEROSCLER REP, V21, DOI 10.1007/s11883-019-0814-6
   Kirkland D, 2015, FOOD CHEM TOXICOL, V84, P161, DOI 10.1016/j.fct.2015.08.021
   KLINE J, 1978, AM J OBSTET GYNECOL, V130, P708, DOI 10.1016/0002-9378(78)90333-2
   Kral TVE, 2008, OBESITY, V16, P1802, DOI 10.1038/oby.2008.287
   Kral TVE, 2020, APPETITE, V151, DOI 10.1016/j.appet.2020.104701
   Latreille M, 2014, J CLIN INVEST, V124, P2722, DOI 10.1172/JCI73066
   Lefterova MI, 2009, TRENDS ENDOCRIN MET, V20, P107, DOI 10.1016/j.tem.2008.11.005
   Liu SR, 2016, MICROB CELL, V3, DOI 10.15698/mic2016.04.492
   Lizunkova P, 2019, GRAEF ARCH CLIN EXP, V257, P71, DOI 10.1007/s00417-018-4157-8
   Lobach AR, 2019, FOOD CHEM TOXICOL, V124, P385, DOI 10.1016/j.fct.2018.12.005
   Lohner S, 2020, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD012885.pub2
   Lutsey PL, 2008, CIRCULATION, V117, P754, DOI 10.1161/CIRCULATIONAHA.107.716159
   Martyn D, 2018, NUTRIENTS, V10, DOI 10.3390/nu10030357
   Martyn DM, 2016, FOOD ADDIT CONTAM A, V33, P592, DOI 10.1080/19440049.2016.1152880
   McNaughton SA, 2008, DIABETES CARE, V31, P1343, DOI 10.2337/dc07-1946
   Meerpohl JJ, 2019, BMJ-BRIT MED J, V364, pK4718, DOI DOI 10.1136/bmj.k4718
   Miceli M, 2019, EXPERT REV CARDIOVAS, V17, P511, DOI 10.1080/14779072.2019.1635012
   Miller PE, 2014, AM J CLIN NUTR, V100, P765, DOI 10.3945/ajcn.113.082826
   Moghadam SD, 2020, OBES SCI PRACT, V6, P229, DOI 10.1002/osp4.397
   Mohamed AAA, 2011, J PLANT PHYSIOL, V168, P1136, DOI 10.1016/j.jplph.2011.01.030
   Monnard CR, 2018, ADV NUTR, V9, P70, DOI 10.1093/advances/nmx023
   Moran AW, 2014, J DAIRY SCI, V97, P4955, DOI 10.3168/jds.2014-8004
   Morenga LT, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.e7492
   Mueller NT, 2015, AM J CLIN NUTR, V102, P648, DOI 10.3945/ajcn.114.100958
   Napoli C, 2002, J AM COLL CARDIOL, V40, P1515, DOI 10.1016/S0735-1097(02)02306-9
   Napoli C, 2006, CIRCULATION, V114, P2517, DOI 10.1161/CIRCULATIONAHA.105.570358
   Napoli C, 2006, NITRIC OXIDE-BIOL CH, V15, P265, DOI 10.1016/j.niox.2006.03.011
   Napoli C, 2020, EUR HEART J-CARD PHA, V6, P239, DOI 10.1093/ehjcvp/pvz062
   Napoli C, 2011, ATHEROSCLEROSIS, V215, P9, DOI 10.1016/j.atherosclerosis.2010.10.039
   Napoli C, 2009, ARCH PHARM RES, V32, P1103, DOI 10.1007/s12272-009-1801-1
   Narain A, 2016, INT J CLIN PRACT, V70, P791, DOI 10.1111/ijcp.12841
   Nettleton JA, 2009, DIABETES CARE, V32, P688, DOI 10.2337/dc08-1799
   Nichol AD, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010029
   O'Connor L, 2015, DIABETOLOGIA, V58, P1474, DOI 10.1007/s00125-015-3572-1
   O'Sullivan AJ, 2017, FOOD ADDIT CONTAM A, V34, P1863, DOI 10.1080/19440049.2017.1363417
   Ojo O, 2014, NUTRIENTS, V6, P5142, DOI 10.3390/nu6115142
   Olas B, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020283
   Olivier-Van Stichelen S, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.01360
   Palmer JR, 2008, ARCH INTERN MED, V168, P1487, DOI 10.1001/archinte.168.14.1487
   Pepin A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11051006
   Pepino MY, 2015, PHYSIOL BEHAV, V152, P450, DOI 10.1016/j.physbeh.2015.06.024
   Pepino MY, 2013, DIABETES CARE, V36, P2530, DOI 10.2337/dc12-2221
   Perrier JD, 2018, FOOD CHEM TOXICOL, V122, P132, DOI 10.1016/j.fct.2018.09.062
   Pham H, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081717
   Popkin BM, 2016, LANCET DIABETES ENDO, V4, P174, DOI 10.1016/S2213-8587(15)00419-2
   PRICE JM, 1970, SCIENCE, V167, P1131, DOI 10.1126/science.167.3921.1131
   Reid AE, 2016, PEDIATRICS, V137, DOI 10.1542/peds.2015-3603
   Renwick AG, 2004, TOXICOL APPL PHARM, V196, P367, DOI 10.1016/j.taap.2004.01.013
   Roberts A, 2016, PHYSIOL BEHAV, V164, P439, DOI 10.1016/j.physbeh.2016.02.039
   Roca-Saavedra P, 2018, J PHYSIOL BIOCHEM, V74, P69, DOI 10.1007/s13105-017-0564-2
   Rogers PJ, 2016, INT J OBESITY, V40, P381, DOI 10.1038/ijo.2015.177
   Romo-Romo A, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0161264
   Rowland I, 2018, EUR J NUTR, V57, P1, DOI 10.1007/s00394-017-1445-8
   Sahajpal NS, 2019, CURR PROTEIN PEPT SC, V20, P92, DOI 10.2174/1389203719666180928123449
   Sanz-Paris A, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030153
   Sasaki YF, 2002, MUTAT RES-GEN TOX EN, V519, P103, DOI 10.1016/S1383-5718(02)00128-6
   Sato K, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20205041
   Scharf RJ, 2016, ANNU REV PUBL HEALTH, V37, P273, DOI 10.1146/annurev-publhealth-032315-021528
   Schiano C, 2020, TOXICOL IN VITRO, V62, DOI 10.1016/j.tiv.2019.104694
   Schiano C, 2019, INT J FOOD SCI NUTR, V70, P725, DOI 10.1080/09637486.2018.1563052
   Schmidt AM, 2017, ARTERIOSCL THROM VAS, V37, P613, DOI 10.1161/ATVBAHA.117.307263
   Schmidt-Lucke C, 2005, CIRCULATION, V111, P2981, DOI 10.1161/CIRCULATIONAHA.104.504340
   Scognamiglio M, 2019, CURR PHARM DESIGN, V25, P85, DOI 10.2174/1381612825666190130101108
   Sedová L, 2007, AM J PHYSIOL-ENDOC M, V292, pE1318, DOI 10.1152/ajpendo.00526.2006
   Shammas AN, 2017, J ENDOVASC THER, V24, P376, DOI 10.1177/1526602817705135
   Sharif S, 2019, DIABETES OBES METAB, V21, P1935, DOI 10.1111/dom.13759
   Simon BR, 2013, J BIOL CHEM, V288, P32475, DOI 10.1074/jbc.M113.514034
   Smeets PAM, 2011, NEUROIMAGE, V54, P1367, DOI 10.1016/j.neuroimage.2010.08.054
   Sommese L, 2018, J DIABETES COMPLICAT, V32, P1076, DOI 10.1016/j.jdiacomp.2018.08.012
   St-Pierre P, 2014, J FUNCT FOODS, V11, P460, DOI 10.1016/j.jff.2014.10.001
   Suez J, 2014, NATURE, V514, P181, DOI 10.1038/nature13793
   Swithers SE, 2013, TRENDS ENDOCRIN MET, V24, P431, DOI 10.1016/j.tem.2013.05.005
   Swithers SE, 2010, PHYSIOL BEHAV, V100, P55, DOI 10.1016/j.physbeh.2009.12.021
   Sylvetsky A, 2011, PEDIATR CLIN N AM, V58, P1467, DOI 10.1016/j.pcl.2011.09.007
   Tandel KR, 2011, J PHARMACOL PHARMACO, V2, P236, DOI 10.4103/0976-500X.85936
   Tarbell J, 2020, J R SOC INTERFACE, V17, DOI 10.1098/rsif.2019.0732
   Tellez LA, 2013, J PHYSIOL-LONDON, V591, P5727, DOI 10.1113/jphysiol.2013.263103
   Temizkan S, 2015, EUR J CLIN NUTR, V69, P162, DOI 10.1038/ejcn.2014.208
   Tian J, 2020, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.00458
   Tian R, 2005, DRUG METAB DISPOS, V33, P547, DOI 10.1124/dmd.104.002485
   Turnbaugh PJ, 2009, J PHYSIOL-LONDON, V587, P4153, DOI 10.1113/jphysiol.2009.174136
   Uebanso T, 2017, NUTRIENTS, V9, DOI [10.3390/nu9060560, 10.3390/nu9060662]
   Valle M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12082292
   Valli V, 2012, J AGR FOOD CHEM, V60, P12508, DOI 10.1021/jf304416d
   Vlassara H, 2013, ENDOCRIN METAB CLIN, V42, P697, DOI 10.1016/j.ecl.2013.07.005
   Vos MB, 2017, CIRCULATION, V135, pE1017, DOI 10.1161/CIR.0000000000000439
   Wang QP, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0199080
   Wang QP, 2016, CELL METAB, V24, P75, DOI 10.1016/j.cmet.2016.06.010
   Watowicz RP, 2015, CHILD OBES, V11, P475, DOI 10.1089/chi.2015.0022
   Weng W, 2020, ENDOCRIN DIAB METAB, V3, DOI 10.1002/edm2.106
   World Health Organization, 2016, OB OV FACT SHEET NO
   Yamagishi S, 2018, ANN VASC DIS, V11, P253, DOI 10.3400/avd.ra.18-00070
   Yamagishi S, 2017, J DIABETES, V9, P141, DOI 10.1111/1753-0407.12475
   Yang SL, 2017, J DIABETES, V9, P133, DOI 10.1111/1753-0407.12474
   Zacharewicz E, 2013, FRONT PHYSIOL, V4, DOI 10.3389/fphys.2013.00266
   Zhu YY, 2017, INT J EPIDEMIOL, V46, P1499, DOI 10.1093/ije/dyx095
NR 165
TC 26
Z9 28
U1 5
U2 65
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0963-9969
EI 1873-7145
J9 FOOD RES INT
JI Food Res. Int.
PD APR
PY 2021
VL 142
AR 110220
DI 10.1016/j.foodres.2021.110220
EA FEB 2021
PG 14
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA RL7OM
UT WOS:000639157600003
PM 33773688
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Jahandideh, F
   Wu, JP
AF Jahandideh, Forough
   Wu, Jianping
TI Perspectives on the Potential Benefits of Antihypertensive Peptides
   towards Metabolic Syndrome
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE antihypertensive peptides; glucose intolerance; inflammation; insulin
   resistance; metabolic syndrome; obesity
ID RENIN-ANGIOTENSIN SYSTEM; TYPE-2 DIABETES-MELLITUS; VAL-PRO-PRO;
   EGG-WHITE HYDROLYSATE; MILK-DERIVED PEPTIDES; C-REACTIVE PROTEIN;
   INSULIN-RESISTANCE; BLOOD-PRESSURE; OXIDATIVE STRESS; BIOACTIVE PEPTIDES
AB In addition to the regulation of blood pressure, the renin-angiotensin system (RAS) also plays a key role in the onset and development of insulin resistance, which is central to metabolic syndrome (MetS). Due to the interplay between RAS and insulin resistance, antihypertensive compounds may exert beneficial effects in the management of MetS. Food-derived bioactive peptides with RAS blocking properties can potentially improve adipose tissue dysfunction, glucose intolerance, and insulin resistance involved in the pathogenesis of MetS. This review discusses the pathophysiology of hypertension and the association between RAS and pathogenesis of the MetS. The effects of bioactive peptides with RAS modulating effects on other components of the MetS are discussed. While the in vivo reports on the effectiveness of antihypertensive peptides against MetS are encouraging, the exact mechanism by which these peptides infer their effects on glucose and lipid handling is mostly unknown. Therefore, careful design of experiments along with standardized physiological models to study the effect of antihypertensive peptides on insulin resistance and obesity could help to clarify this relationship.
C1 [Jahandideh, Forough; Wu, Jianping] Univ Alberta, Fac Agr Life & Environm Sci, Dept Agr Food & Nutr Sci, Edmonton, AB T6G 2P5, Canada.
   [Jahandideh, Forough; Wu, Jianping] Univ Alberta, Fac Med & Dent, Cardiovasc Res Ctr, Edmonton, AB T6G 2S2, Canada.
C3 University of Alberta; University of Alberta
RP Jahandideh, F; Wu, JP (corresponding author), Univ Alberta, Fac Agr Life & Environm Sci, Dept Agr Food & Nutr Sci, Edmonton, AB T6G 2P5, Canada.; Jahandideh, F; Wu, JP (corresponding author), Univ Alberta, Fac Med & Dent, Cardiovasc Res Ctr, Edmonton, AB T6G 2S2, Canada.
EM jahandid@ualberta.ca; jwu3@ualberta.ca
RI Wu, Jianping/H-9150-2012; Jahandideh, Forough/M-4648-2019
OI Jahandideh, Forough/0000-0001-9731-0854
FU Alberta Agriculture and Forestry; Egg Farmers of Alberta; Natural
   Sciences and Engineering Research Council (NSERC) of Canada; Egg Farmers
   of Canada
FX This research was supported by grants from Alberta Agriculture and
   Forestry, Egg Farmers of Canada, Egg Farmers of Alberta, and Natural
   Sciences and Engineering Research Council (NSERC) of Canada to J. Wu.
CR Aihara K, 2005, J AM COLL NUTR, V24, P257, DOI 10.1080/07315724.2005.10719473
   Aihara K, 2014, BRIT J NUTR, V112, P513, DOI 10.1017/S0007114514001147
   Akoumianakis I, 2019, ANTIOXID REDOX SIGN, V30, P333, DOI 10.1089/ars.2017.7421
   Anderson EJ, 2009, J CLIN INVEST, V119, P573, DOI 10.1172/JCI37048
   Ardalan MR, 2014, J RENAL INJ PREV, V3, P39, DOI 10.12861/jrip.2014.13
   Bindom SM, 2010, DIABETES, V59, P2540, DOI 10.2337/db09-0782
   Bitkin EÇ, 2013, J CLIN RES PEDIATR E, V5, P164, DOI 10.4274/Jcrpe.1020
   Boelsma E, 2010, NUTR J, V9, DOI 10.1186/1475-2891-9-52
   Brieger K, 2012, SWISS MED WKLY, V142, DOI 10.4414/smw.2012.13659
   Cavazos A, 2013, COMPR REV FOOD SCI F, V12, P364, DOI 10.1111/1541-4337.12017
   Chakrabarti S, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0117492
   Chakrabarti S, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/608979
   Chanson-Rolle A, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0142235
   Chattopadhyay M, 2015, MOL CELL BIOCHEM, V399, P95, DOI 10.1007/s11010-014-2236-7
   Chen JL, 2019, MAR DRUGS, V17, DOI 10.3390/md17070431
   Chen JW, 2006, ATHEROSCLEROSIS, V184, P295, DOI 10.1016/j.atherosclerosis.2005.04.016
   Cheung RCF, 2015, MAR DRUGS, V13, P4006, DOI 10.3390/md13074006
   Chou CL, 2013, HYPERTENS RES, V36, P123, DOI 10.1038/hr.2012.124
   Chou CL, 2011, ARCH MED SCI, V7, P882, DOI 10.5114/aoms.2011.25566
   Chowdhury SKR, 2010, AM J PHYSIOL-ENDOC M, V298, pE89, DOI 10.1152/ajpendo.00433.2009
   Cicero AFG, 2016, PHYTOMEDICINE, V23, P1134, DOI 10.1016/j.phymed.2015.11.009
   Cooper ME, 2004, AM J HYPERTENS, V17, p16S, DOI 10.1016/j.amjhyper.2004.08.004
   Cooper SA, 2007, AM J PHYSIOL-HEART C, V293, pH2009, DOI 10.1152/ajpheart.00522.2007
   Ngo DH, 2014, FOOD CHEM, V143, P246, DOI 10.1016/j.foodchem.2013.07.067
   Ngo DH, 2011, INT J BIOL MACROMOL, V49, P1110, DOI 10.1016/j.ijbiomac.2011.09.009
   Daskaya-Dikmen C, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040316
   Deanfield JE, 2007, CIRCULATION, V115, P1285, DOI 10.1161/CIRCULATIONAHA.106.652859
   Deedwania PC, 2005, CARDIOL CLIN, V23, P165, DOI 10.1016/j.ccl.2004.11.003
   DIA V, 2013, FASEB J, V27, P863
   Engberink MF, 2008, HYPERTENSION, V51, P399, DOI 10.1161/HYPERTENSIONAHA.107.098988
   Engeli S, 2006, HYPERTENSION, V48, P1103, DOI 10.1161/01.HYP.0000248837.88749.18
   Erdmann K, 2008, J NUTR BIOCHEM, V19, P643, DOI 10.1016/j.jnutbio.2007.11.010
   Erdmann K, 2006, J NUTR, V136, P2148, DOI 10.1093/jn/136.8.2148
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   Fernandes L, 2001, HYPERTENSION, V37, P703, DOI 10.1161/01.HYP.37.2.703
   FERRANNINI E, 1987, NEW ENGL J MED, V317, P350, DOI 10.1056/NEJM198708063170605
   FIORUCCI S, 2009, J PHARMACOL EXP THER, V329, P848
   Fogari R, 2010, HORM METAB RES, V42, P892, DOI 10.1055/s-0030-1263123
   Förstermann U, 2006, CIRCULATION, V113, P1708, DOI 10.1161/CIRCULATIONAHA.105.602532
   Garcés-Rimón M, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0151193
   Garcés-Rimón M, 2016, EUR FOOD RES TECHNOL, V242, P61, DOI 10.1007/s00217-015-2518-7
   Giacchetti G, 2002, AM J HYPERTENS, V15, P381, DOI 10.1016/S0895-7061(02)02257-4
   Giani JF, 2009, AM J PHYSIOL-ENDOC M, V296, pE262, DOI 10.1152/ajpendo.90678.2008
   Girgih AT, 2014, NUTRIENTS, V6, P5652, DOI 10.3390/nu6125652
   Goossens GH, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039930
   Grundy SM, 2016, TRENDS CARDIOVAS MED, V26, P364, DOI 10.1016/j.tcm.2015.10.004
   Guang C, 2009, J AGR FOOD CHEM, V57, P5113, DOI 10.1021/jf900494d
   Han TS, 2016, JRSM CARDIOVASC DIS, V5, DOI 10.1177/2048004016633371
   Han TS, 2002, DIABETES CARE, V25, P2016, DOI 10.2337/diacare.25.11.2016
   Hansson L, 1999, LANCET, V353, P611, DOI 10.1016/S0140-6736(98)05012-0
   Henriksen EJ, 2007, AM J PHYSIOL-REG I, V293, pR974, DOI 10.1152/ajpregu.00147.2007
   Henriksen EJ, 2013, MOL CELL ENDOCRINOL, V378, P15, DOI 10.1016/j.mce.2012.04.011
   Higuchi S, 2007, CLIN SCI, V112, P417, DOI 10.1042/CS20060342
   Himaya SWA, 2012, FOOD CHEM, V132, P1872, DOI 10.1016/j.foodchem.2011.12.020
   Holvoet P, 2004, DIABETES, V53, P1068, DOI 10.2337/diabetes.53.4.1068
   Hrenak J, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17071098
   Hsueh WA, 2011, J CLIN HYPERTENS, V13, P224, DOI 10.1111/j.1751-7176.2011.00449.x
   Huang WY, 2010, FOOD CHEM, V123, P635, DOI 10.1016/j.foodchem.2010.04.083
   Huang WY, 2010, J AGR FOOD CHEM, V58, P10840, DOI 10.1021/jf102120c
   Iwaniak A, 2014, COMPR REV FOOD SCI F, V13, P114, DOI 10.1111/1541-4337.12051
   Jahandideh F, 2019, BRIT J NUTR, V122, P14, DOI 10.1017/S0007114519000837
   Jahandideh F, 2018, FOOD CHEM, V259, P25, DOI 10.1016/j.foodchem.2018.03.099
   Jahandideh F, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0185653
   Jahandideh F, 2016, J FUNCT FOODS, V27, P667, DOI 10.1016/j.jff.2016.10.019
   Jahandideh F, 2016, J AGR FOOD CHEM, V64, P113, DOI 10.1021/acs.jafc.5b04230
   Jahandideh F, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0115006
   Janssen-Heininger YMW, 2008, FREE RADICAL BIO MED, V45, P1, DOI 10.1016/j.freeradbiomed.2008.03.011
   Jaworek J, 2003, J PINEAL RES, V34, P40, DOI 10.1034/j.1600-079X.2003.02937.x
   Kaplan NM, 2001, ANN INTERN MED, V135, P1079, DOI 10.7326/0003-4819-135-12-200112180-00012
   Kawasaki T, 2000, J HUM HYPERTENS, V14, P519, DOI 10.1038/sj.jhh.1001065
   Kayama Y, 2015, INT J MOL SCI, V16, P25234, DOI 10.3390/ijms161025234
   KEIDAR S, 1995, ATHEROSCLEROSIS, V115, P201, DOI 10.1016/0021-9150(94)05514-J
   Khwa WS, 2015, IEEE INT MEM WORKSH, P181
   Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213
   Kim SM, 2008, FASEB J, V22
   Korhonen H, 2006, INT DAIRY J, V16, P945, DOI 10.1016/j.idairyj.2005.10.012
   Lassègue B, 2010, ARTERIOSCL THROM VAS, V30, P653, DOI 10.1161/ATVBAHA.108.181610
   Lautner RQ, 2013, CIRC RES, V112, P1104, DOI 10.1161/CIRCRESAHA.113.301077
   Lavoie JL, 2003, ENDOCRINOLOGY, V144, P2179, DOI 10.1210/en.2003-0150
   Lee MH, 2008, KIDNEY INT, V74, P890, DOI 10.1038/ki.2008.313
   Li DF, 2000, ANN PURE APPL LOGIC, V102, P1, DOI 10.1016/S0168-0072(99)00031-7
   Li YW, 2017, ATHEROSCLEROSIS, V259, P75, DOI 10.1016/j.atherosclerosis.2017.02.003
   Liao W, 2018, J AGR FOOD CHEM, V66, P11330, DOI 10.1021/acs.jafc.8b03501
   Lindholm LH, 2002, J HYPERTENS, V20, P1879, DOI 10.1097/00004872-200209000-00035
   Liu C, 2012, ACTA DIABETOL, V49, P291, DOI 10.1007/s00592-011-0348-z
   Liu J, 2014, EUR REV MED PHARMACO, V18, P2070
   Lü JM, 2010, J CELL MOL MED, V14, P840, DOI 10.1111/j.1582-4934.2009.00897.x
   Maeda A, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/946492
   Majumder K, 2015, MOL NUTR FOOD RES, V59, P1735, DOI 10.1002/mnfr.201500050
   Majumder K, 2015, J FUNCT FOODS, V13, P50, DOI 10.1016/j.jff.2014.12.028
   Majumder K, 2015, INT J MOL SCI, V16, P256, DOI 10.3390/ijms16010256
   Majumder K, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0082829
   Majumder K, 2013, J AGR FOOD CHEM, V61, P2120, DOI 10.1021/jf3046076
   Majumder K, 2011, FOOD CHEM, V126, P1614, DOI 10.1016/j.foodchem.2010.12.039
   Manikkam V, 2016, CRIT REV FOOD SCI, V56, P92, DOI 10.1080/10408398.2012.753866
   Marcone S, 2017, BRIT J CLIN PHARMACO, V83, P152, DOI 10.1111/bcp.13002
   Marcus Y, 2013, MOL CELL ENDOCRINOL, V378, P1, DOI 10.1016/j.mce.2012.06.021
   Matsuda M, 2013, OBES RES CLIN PRACT, V7, pE330, DOI 10.1016/j.orcp.2013.05.004
   Mazidi M, 2018, ANGIOLOGY, V69, P438, DOI 10.1177/0003319717729288
   Mendizábal Y, 2013, INT J HYPERTENS, V2013, DOI 10.1155/2013/230868
   Miguel M, 2007, FOOD CHEM, V104, P163, DOI 10.1016/j.foodchem.2006.11.016
   Miguel M, 2006, J NUTR, V136, P1457, DOI 10.1093/jn/136.6.1457
   Mirhafez SR, 2016, EUR J CLIN NUTR, V70, P1298, DOI 10.1038/ejcn.2016.111
   Moreno-Fernández S, 2018, FOOD FUNCT, V9, P78, DOI [10.1039/C7FO01280B, 10.1039/c7fo01280b]
   Mule G, 2006, Minerva Cardioangiol, V54, P173
   Nakamura T, 2013, J MED FOOD, V16, P396, DOI 10.1089/jmf.2012.2541
   Nerenberg KA, 2018, CAN J CARDIOL, V34, P506, DOI 10.1016/j.cjca.2018.02.022
   Nevelsteen I, 2013, BMC CARDIOVASC DISOR, V13, DOI 10.1186/1471-2261-13-51
   Nonaka A, 2014, HYPERTENS RES, V37, P703, DOI 10.1038/hr.2014.72
   Oda E, 2012, ACTA DIABETOL, V49, P89, DOI 10.1007/s00592-011-0309-6
   Olivares-Reyes JA, 2009, MOL CELL ENDOCRINOL, V302, P128, DOI 10.1016/j.mce.2008.12.011
   Oparil S, 2003, ANN INTERN MED, V139, P761, DOI 10.7326/0003-4819-139-9-200311040-00011
   Otani H, 2011, ANTIOXID REDOX SIGN, V15, P1911, DOI 10.1089/ars.2010.3739
   Otani L, 2009, BIOSCI BIOTECH BIOCH, V73, P2203, DOI 10.1271/bbb.90311
   Ovchinnikova TV, 2019, MAR DRUGS, V17, DOI 10.3390/md17090505
   Panahi Y, 2015, CLIN NUTR, V34, P1101, DOI 10.1016/j.clnu.2014.12.019
   Park KH, 2009, BBA-BIOMEMBRANES, V1788, P1193, DOI 10.1016/j.bbamem.2009.02.020
   Park SE, 2013, METABOLISM, V62, P532, DOI 10.1016/j.metabol.2012.09.013
   Paul M, 2006, PHYSIOL REV, V86, P747, DOI 10.1152/physrev.00036.2005
   Ocaranza MP, 2016, HYPERTENSION, V68, P552, DOI 10.1161/HYPERTENSIONAHA.116.07471
   Perazella MA, 2003, J NUCL CARDIOL, V10, P184, DOI 10.1067/mnc.2003.392
   Pham-Huy Lien Ai, 2008, Int J Biomed Sci, V4, P89
   Pober JS, 2007, NAT REV IMMUNOL, V7, P803, DOI 10.1038/nri2171
   Poli G, 2004, CURR MED CHEM, V11, P1163, DOI 10.2174/0929867043365323
   Povel CM, 2013, DIABETES CARE, V36, P362, DOI 10.2337/dc11-2546
   Prasad H, 2012, POSTGRAD MED, V124, P21, DOI 10.3810/pgm.2012.01.2514
   Putnam K, 2012, AM J PHYSIOL-HEART C, V302, pH1219, DOI 10.1152/ajpheart.00796.2011
   Rajendran P, 2013, INT J BIOL SCI, V9, P1057, DOI 10.7150/ijbs.7502
   Rangel-Huerta OD, 2015, J NUTR, V145, P1808, DOI 10.3945/jn.115.213660
   Rodrigo R, 2008, CLIN SCI, V114, P625, DOI 10.1042/CS20070343
   Ruiz-Ramírez A, 2014, CLIN SCI, V126, P19, DOI 10.1042/CS20130164
   Samuelsson AM, 2006, AM J PHYSIOL-HEART C, V291, pH787, DOI 10.1152/ajpheart.00974.2005
   Santos SHS, 2010, ARTERIOSCL THROM VAS, V30, P953, DOI 10.1161/ATVBAHA.109.200493
   Sarzani R, 2008, INT J OBESITY, V32, P259, DOI 10.1038/sj.ijo.0803724
   Scheen AJ, 2004, DIABETES METAB, V30, P498, DOI 10.1016/S1262-3636(07)70147-7
   Scheen AJ, 2004, DRUGS, V64, P2537, DOI 10.2165/00003495-200464220-00004
   Schillaci G, 2004, J AM COLL CARDIOL, V43, P1817, DOI 10.1016/j.jacc.2003.12.049
   Schulz E, 2011, HYPERTENS RES, V34, P665, DOI 10.1038/hr.2011.39
   Segura J, 2007, PUBLIC HEALTH NUTR, V10, P1151, DOI 10.1017/S136898000700064X
   Sharma Arya M, 2006, J Cardiometab Syndr, V1, P29, DOI 10.1111/j.0197-3118.2006.05422.x
   Shinozaki K, 2004, HYPERTENSION, V43, P255, DOI 10.1161/01.HYP.0000111136.86976.26
   Silveira JQ, 2015, INT J FOOD SCI NUTR, V66, P830, DOI 10.3109/09637486.2015.1093610
   Singh BP, 2014, PEPTIDES, V54, P171, DOI 10.1016/j.peptides.2014.01.022
   Solieri L, 2015, FOOD MICROBIOL, V51, P108, DOI 10.1016/j.fm.2015.05.012
   Somlyo AP, 2003, PHYSIOL REV, V83, P1325, DOI 10.1152/physrev.00023.2003
   Son M, 2019, EUR J NUTR, V58, P1961, DOI 10.1007/s00394-018-1753-7
   Son MJ, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700602
   Sowers JR, 2004, AM J PHYSIOL-HEART C, V286, pH1597, DOI 10.1152/ajpheart.00026.2004
   Spahis S, 2017, ANTIOXID REDOX SIGN, V26, P445, DOI 10.1089/ars.2016.6756
   Sprague AH, 2009, BIOCHEM PHARMACOL, V78, P539, DOI 10.1016/j.bcp.2009.04.029
   Stefano GB, 2016, EUR J NUTR, V55, P2339, DOI 10.1007/s00394-016-1212-2
   Stull AJ, 2015, NUTRIENTS, V7, P4107, DOI 10.3390/nu7064107
   Szabo C, 2009, BRIT J PHARMACOL, V156, P713, DOI 10.1111/j.1476-5381.2008.00086.x
   Udenigwe CC, 2012, J FOOD SCI, V77, pR11, DOI 10.1111/j.1750-3841.2011.02455.x
   Underwood PC, 2013, CURR HYPERTENS REP, V15, P59, DOI 10.1007/s11906-012-0323-2
   Urquiaga I, 2015, BIOL RES, V48, DOI [10.1186/s40659-015-0040-9, 10.1186/S40659-015-0040-9]
   Van der Mieren G, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-36
   Virdis A, 2004, J HYPERTENS, V22, P535, DOI 10.1097/00004872-200403000-00016
   Vona R, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8267234
   Wang YM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046781
   Wassmann S, 2006, J HYPERTENS, V24, pS15, DOI 10.1097/01.hjh.0000220402.53869.72
   Wassmann S, 2004, HYPERTENSION, V44, P381, DOI 10.1161/01.HYP.0000142232.29764.a7
   Xu J, 2009, CIRCULATION, V120, P1266, DOI 10.1161/CIRCULATIONAHA.108.835223
   Yakubova A, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-34547-9
   Yasue S, 2010, AM J HYPERTENS, V23, P425, DOI 10.1038/ajh.2009.263
   Yim Hyung Eun, 2008, Electrolyte Blood Press, V6, P42, DOI 10.5049/EBP.2008.6.1.42
   Yu ZP, 2017, J SCI FOOD AGR, V97, P551, DOI 10.1002/jsfa.7762
   Zambrowicz A, 2015, RSC ADV, V5, P10460, DOI 10.1039/c4ra12943a
   Zani SCD, 2018, NUTRIENTS, V10, DOI 10.3390/nu10050549
   Zappe DH, 2008, J CLIN HYPERTENS, V10, P894, DOI 10.1111/j.1751-7176.2008.00054.x
   Zhang SS, 2018, MAR DRUGS, V16, DOI 10.3390/md16120473
   Zhu CF, 2010, NUTRITION, V26, P1014, DOI 10.1016/j.nut.2010.01.011
NR 173
TC 24
Z9 25
U1 1
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2020
VL 21
IS 6
AR 2192
DI 10.3390/ijms21062192
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA LJ0UU
UT WOS:000529890200288
PM 32235782
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sabe, AA
   Sadek, AA
   Elmadhun, NY
   Dalal, RS
   Robich, MP
   Bianchi, C
   Sellke, FW
AF Sabe, Ashraf A.
   Sadek, Ahmed A.
   Elmadhun, Nassrene Y.
   Dalal, Rahul S.
   Robich, Michael P.
   Bianchi, Cesario
   Sellke, Frank W.
TI Investigating the Effects of Resveratrol on Chronically Ischemic
   Myocardium in a Swine Model of Metabolic Syndrome: A Proteomics Analysis
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Article
DE metabolic syndrome; ischemic heart disease; proteomics; remodeling;
   metabolism; resveratrol
ID CORONARY-ARTERY-DISEASE; MUTATION; STRESS; MICE
AB Resveratrol has been shown to improve cardiac perfusion and ventricular function after chronic ischemic injury. Using proteomic analysis, we sought to objectively investigate potential mechanisms, by which resveratrol exerts its cardioprotective effects in the setting of metabolic syndrome and chronic myocardial ischemia. Yorkshire swine were divided into two groups based on diet: high cholesterol (n=7) or a high-cholesterol diet with supplemental resveratrol (n=6). Four weeks later, all animals underwent surgical placement of an ameroid constrictor to their left circumflex artery. Diets were continued for another 7 weeks, and then the ischemic myocardium was harvested for proteomics analysis. Proteomic analysis identified 669 common proteins between the two groups. Of these proteins, 76 were statistically different, of which 41 were characterized (P<.05). Pathway analysis demonstrated that in animals supplemented with resveratrol, there was a downregulation in several proteins involved with mitochondrial dysfunction, cell death, and unfavorable cardiac remodeling. Furthermore, there was an upregulation in proteins involved in free radical elimination. We conclude that resveratrol supplementation significantly alters several critical protein markers in the chronically ischemic myocardium. Further investigation of these proteins may help elucidate the mechanisms by which resveratrol exerts its cardioprotective effects.
C1 [Sabe, Ashraf A.; Sadek, Ahmed A.; Elmadhun, Nassrene Y.; Dalal, Rahul S.; Robich, Michael P.; Bianchi, Cesario; Sellke, Frank W.] Brown Univ, Warren Alpert Sch Med, Div Cardiothorac Surg, Cardiovasc Res Ctr, Providence, RI 02905 USA.
C3 Brown University
RP Sellke, FW (corresponding author), Brown Univ, Warren Alpert Sch Med, Div Cardiothorac Surg, Cardiovasc Res Ctr, 2 Dudley St,MOC 360, Providence, RI 02905 USA.
EM fsellke@lifespan.org
RI bianchi, cesario/H-6238-2012; Dalal, Rahul/AAH-1965-2021
OI Dalal, Rahul/0000-0003-4622-8441
FU National Heart, Lung, and Blood Institute [R01HL46716, R01HL69024,
   R01HL85647]; NIH [5T32-HL094300-03, T32-HL0074]
FX Funding for this research was provided by the National Heart, Lung, and
   Blood Institute (R01HL46716, R01HL69024, and R01HL85647, Dr. F.W.S.),
   NIH Training grant 5T32-HL094300-03 (Dr. A.A.S. and Dr. N.Y.E.), and NIH
   Training grant T32-HL0074 (Dr. M.P.R.).
CR Baur JA, 2006, NATURE, V444, P337, DOI 10.1038/nature05354
   Baur JA, 2006, NAT REV DRUG DISCOV, V5, P493, DOI 10.1038/nrd2060
   Burgess TA, 2011, ARCH SURG-CHICAGO, V146, P556, DOI 10.1001/archsurg.2011.100
   Cha MK, 2000, BIOCHEMISTRY-US, V39, P6944, DOI 10.1021/bi000034j
   Chopra N, 2011, CURR OPIN CARDIOL, V26, P196, DOI 10.1097/HCO.0b013e3283459893
   Chu LM, 2011, CURR ATHEROSCLER REP, V13, P439, DOI 10.1007/s11883-011-0202-3
   Elmadhun NY, 2013, ANN NY ACAD SCI, V1290, P130, DOI 10.1111/nyas.12216
   Ishii N, 2006, EXP GERONTOL, V41, P952, DOI 10.1016/j.exger.2006.06.037
   Kanamori H, 2013, AM J PATHOL, V182, P701, DOI 10.1016/j.ajpath.2012.11.009
   Karibe A, 2001, CIRCULATION, V103, P65
   Price NL, 2012, CELL METAB, V15, P675, DOI 10.1016/j.cmet.2012.04.003
   Robich MP, 2011, EUR J PHARMACOL, V664, P45, DOI 10.1016/j.ejphar.2011.04.059
   Robich MP, 2010, CIRCULATION, V122, pS142, DOI 10.1161/CIRCULATIONAHA.109.920132
   Sabe AA, 2013, J SURG RES, V183, P531, DOI 10.1016/j.jss.2013.03.004
   Slane BG, 2006, CANCER RES, V66, P7615, DOI 10.1158/0008-5472.CAN-06-0833
   Xuan WL, 2012, CRIT CARE MED, V40, P3026, DOI 10.1097/CCM.0b013e31825fd7da
   Yang SH, 2011, BIOL REPROD, V84, P1182, DOI 10.1095/biolreprod.110.087569
   Zuppini A, 2002, BIOCHEMISTRY-US, V41, P2850, DOI 10.1021/bi015967+
NR 18
TC 11
Z9 11
U1 0
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD JAN 1
PY 2015
VL 18
IS 1
BP 60
EP 66
DI 10.1089/jmf.2014.0036
PG 7
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA AY2BL
UT WOS:000347393400007
PM 25089828
OA Green Published
DA 2025-06-11
ER

PT J
AU Bungau, SG
   Tit, DM
   Vesa, CM
   Abid, A
   Szilagyi, DV
   Radu, AF
   Bungau, AF
   Tarce, AG
   Behl, T
   Stoicescu, M
   Brisc, CM
   Gitea, D
   Nechifor, AC
   Endres, L
AF Bungau, Simona Gabriela
   Tit, Delia Mirela
   Vesa, Cosmin Mihai
   Abid, Areha
   Szilagyi, Denisa-Viola
   Radu, Andrei-Flavius
   Bungau, Alexa Florina
   Tarce, Alexandra Georgiana
   Behl, Tapan
   Stoicescu, Manuela
   Brisc, Cristina Mihaela
   Gitea, Daniela
   Nechifor, Aurelia Cristina
   Endres, Laura
TI Non-conventional therapeutical approaches to acne vulgaris related to
   its association with metabolic disorders
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Acne vulgaris; Insulin resistance; Metabolic syndrome; Pathogenesis;
   Dietary and therapeutical interventions; Non-conventional therapeutical
   approach
ID GLYCEMIC-LOAD DIET; LOW-FAT DIET; INSULIN-RESISTANCE;
   PROPIONIBACTERIUM-ACNES; ORAL ZINC; OXIDATIVE STRESS; VITAMIN-A;
   ANTIMICROBIAL ACTIVITY; INFLAMMATORY RESPONSE; CHEMICAL-COMPOSITION
AB The ever-increasing frequency of metabolic syndrome (MetS) is still a major challenge of the public health care system, worldwide. In recent years, researchers have been drawn to the uncommon (at first look) link between skin illnesses and MetS. Because of the pro-inflammatory mechanisms and insulin resistance (IR) that are upregulated in metabolic syndrome, many skin disorders are correlated to metabolic dysfunctions, including acne vulgaris. A comprehensive understanding of the link between MetS and acne vulgaris may contribute to the development of new treatment strategies. The current review focuses on dietary and therapeutic interventions and assesses the effect of various approaches such as improving diet by avoiding certain food products (i.e., milk and chocolate) or increasing the intake of others (i.e., food products rich in omega-3 fatty acids), metformin administration, therapy with plant extracts, plant essential oils, and probiotic supplementation on the improvement of certain acne vulgaris severity parameters. These therapeutic approaches, when combined with allopathic treatment, can improve the patients' quality of life.
C1 [Bungau, Simona Gabriela; Tit, Delia Mirela; Gitea, Daniela] Univ Oradea, Fac Med & Pharm, Dept Pharm, Oradea 410028, Romania.
   [Bungau, Simona Gabriela; Tit, Delia Mirela; Szilagyi, Denisa-Viola; Radu, Andrei-Flavius] Univ Oradea, Doctoral Sch Biol & Biomed Sci, Oradea 410087, Romania.
   [Vesa, Cosmin Mihai] Univ Oradea, Fac Med & Pharm, Dept Preclin Disciplines, Oradea 410073, Romania.
   [Abid, Areha] Univ Saskatchewan, Coll Agr & Bioresources, Dept Food & Bioprod Sci, Saskatoon, SK, Canada.
   [Bungau, Alexa Florina; Tarce, Alexandra Georgiana] Univ Oradea, Fac Med & Pharm, Oradea 410073, Romania.
   [Behl, Tapan] Chitkara Univ, Chitkara Coll Pharm, Dept Pharmacol, Rajpura 140401, Punjab, India.
   [Stoicescu, Manuela; Brisc, Cristina Mihaela] Univ Oradea, Fac Med & Pharm, Dept Med Disciplines, Oradea 410073, Romania.
   [Nechifor, Aurelia Cristina] Univ Politehn Bucuresti, Analyt Chem & Environm Engn Dept, Bucharest 011061, Romania.
   [Endres, Laura] Univ Oradea, Fac Med & Pharm, Dept Psychoneurosci & Recovery, Oradea 410073, Romania.
C3 University of Oradea; University of Oradea; University of Oradea;
   University of Saskatchewan; University of Oradea; Chitkara University,
   Punjab; University of Oradea; National University of Science &
   Technology POLITEHNICA Bucharest; University of Oradea
RP Tit, DM (corresponding author), Univ Oradea, Fac Med & Pharm, Dept Pharm, Oradea 410028, Romania.; Vesa, CM (corresponding author), Univ Oradea, Fac Med & Pharm, Dept Preclin Disciplines, Oradea 410073, Romania.
EM simonabungau@gmail.com; mirela_tit@yahoo.com; v_cosmin_15@yahoo.com;
   areha.abid786@gmail.com; deni02viola@gmail.com;
   andreiflavius.radu@gmail.com; pradaalexaflorina@gmail.com;
   tarce_alexandra@yahoo.com; tapanbehl31@gmail.com;
   manuela_stoicescu@yahoo.com; briscristina@yahoo.com;
   gitea_daniela@yahoo.co.uk; aureliacristinanechifor@gmail.com;
   laura_endres@yahoo.com
RI Bungau, Simona Gabriela/C-1831-2015; DANIELA, GITEA/AAL-7932-2020; Radu,
   Andrei-Flavius/AAD-3129-2022; Szilagyi, Denisa Viola/AHA-6618-2022; Tit,
   Delia/AAT-5032-2020; Brisc, Mihaela Cristina/AAC-9003-2022; Stoicescu,
   Manuela/AAC-9008-2022; Bungau, Alexa/AGY-4752-2022; Endres,
   Laura/AAY-5100-2020; Alexandra Georgiana, Tarce/AHC-5764-2022; Mihai,
   Vesa/AAE-5495-2019; Behl, Tapan/W-3523-2019; Aurelia Cristina,
   Nechifor/AAD-4286-2022
OI RADU, ANDREI-FLAVIUS/0000-0002-7625-8177; Tit, Delia
   Mirela/0000-0002-0296-6592; /0000-0003-3236-1292; Cosmin Mihai,
   Vesa/0000-0001-5071-9601; Szilagyi, Denisa Viola/0000-0002-7491-1099;
   Bungau, Alexa/0000-0002-7300-3646; DANIELA, GITEA/0000-0002-1052-8496
FU Romanian Ministry of Research,Innovation and Digitisation through
   Programme 1 - Development of the National Research and Development
   System, Subprogramme 1.2 - Institutional Performance - Projects [29
   PFE/30.12.2021]; Oradea, Romania
FX This research was supported by the Romanian Ministry of
   Research,Innovation and Digitisation through Programme 1 - Development
   of the National Research and Development System, Subprogramme 1.2 -
   Institutional Performance - Projects for funding the excellence in RDI,
   Contract No. 29 PFE/30.12.2021 with University of Oradea, Oradea,
   Romania.
CR ABBOTT WGH, 1990, AM J PHYSIOL, V258, pE347, DOI 10.1152/ajpendo.1990.258.2.E347
   Adebamowo CA, 2005, J AM ACAD DERMATOL, V52, P207, DOI 10.1016/j.jaad.2004.08.007
   Adebamowo CA, 2008, J AM ACAD DERMATOL, V58, P787, DOI 10.1016/j.jaad.2007.08.049
   Adeshirlarijaney A, 2019, AM J PHYSIOL-ENDOC M, V317, pE1121, DOI 10.1152/ajpendo.00245.2019
   Ak M., 2019, J Clin Pharm, V1, P17, DOI DOI 10.15226/2378-1726/6/2/00186
   Akhtar N, 2010, J PHARM BIOALLIED SC, V2, P13, DOI 10.4103/0975-7406.62698
   Alebiosu CO, 2003, J NATL MED ASSOC, V95, P95
   AMER M, 1982, INT J DERMATOL, V21, P481, DOI 10.1111/j.1365-4362.1982.tb03188.x
   Arbesman H, 2005, J AM ACAD DERMATOL, V53, P1102, DOI 10.1016/j.jaad.2005.05.046
   Arora A, 2021, LIFE SCI, V273, DOI 10.1016/j.lfs.2021.119311
   Arora MK, 2014, CLIN LAB, V60, P1201, DOI 10.7754/Clin.Lab.2013.120811
   Arora MK, 2011, CLIN BIOCHEM, V44, P1035, DOI 10.1016/j.clinbiochem.2011.06.984
   Bagheri N, 2013, MICROB PATHOGENESIS, V65, P7, DOI 10.1016/j.micpath.2013.08.005
   Bahmani M, 2014, ASIAN PAC J TROP MED, V7, pS348, DOI 10.1016/S1995-7645(14)60257-1
   BASSETT IB, 1990, MED J AUSTRALIA, V153, P455, DOI 10.5694/j.1326-5377.1990.tb126150.x
   Behrangi E., 2019, Iranian Journal of Dermatology, V22, P47
   BENDINER E, 1974, HOSP PRACT, V9, P156
   BERSHAD S, 1985, NEW ENGL J MED, V313, P981, DOI 10.1056/NEJM198510173131604
   Block Samantha G, 2011, J Am Acad Dermatol, V65, pe114, DOI 10.1016/j.jaad.2010.08.015
   BORKMAN M, 1991, J CLIN ENDOCR METAB, V72, P432, DOI 10.1210/jcem-72-2-432
   Bowe WP, 2008, SEMIN CUTAN MED SURG, V27, P170, DOI 10.1016/j.sder.2008.07.004
   Bowe Whitney P, 2006, J Drugs Dermatol, V5, P868
   Bowe WP, 2011, GUT PATHOG, V3, DOI 10.1186/1757-4749-3-1
   Bowe WP, 2010, J AM ACAD DERMATOL, V63, P124, DOI 10.1016/j.jaad.2009.07.043
   Brynes AE, 2000, AM J CLIN NUTR, V72, P1111
   Buerger C, 2012, J INVEST DERMATOL, V132, P2206, DOI 10.1038/jid.2012.123
   Bustamante M, 2020, FOLIA MICROBIOL, V65, P245, DOI 10.1007/s12223-019-00759-3
   Butel MJ, 2014, MED MALADIES INFECT, V44, P1, DOI 10.1016/j.medmal.2013.10.002
   Calder PC, 2010, NUTRIENTS, V2, P355, DOI 10.3390/nu2030355
   Chen W, 2011, J EUR ACAD DERMATOL, V25, P637, DOI 10.1111/j.1468-3083.2010.03937.x
   Chung MM, 2017, EXP CELL RES, V352, P75, DOI 10.1016/j.yexcr.2017.01.017
   Clark AK, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18051070
   Coenye T, 2007, RES MICROBIOL, V158, P386, DOI 10.1016/j.resmic.2007.02.001
   Cogen AL, 2008, BRIT J DERMATOL, V158, P442, DOI 10.1111/j.1365-2133.2008.08437.x
   Cong TX, 2019, ARCH DERMATOL RES, V311, P337, DOI 10.1007/s00403-019-01908-x
   Cordain L, 2002, ARCH DERMATOL, V138, P1584, DOI 10.1001/archderm.138.12.1584
   Cosseau C, 2008, INFECT IMMUN, V76, P4163, DOI 10.1128/IAI.00188-08
   Costa A, 2010, AN BRAS DERMATOL, V85, P346, DOI 10.1590/S0365-05962010000300008
   Dahl L, 2003, BRIT J NUTR, V90, P679, DOI 10.1079/BJN2003921
   Danby FW, 2005, J AM ACAD DERMATOL, V52, P360, DOI 10.1016/j.jaad.2004.09.022
   Davidovici BB, 2010, J INVEST DERMATOL, V130, P1785, DOI 10.1038/jid.2010.103
   Degitz Klaus, 2007, J Dtsch Dermatol Ges, V5, P316, DOI 10.1111/j.1610-0387.2007.06274.x
   Dobbins RL, 2002, DIABETES, V51, P1825, DOI 10.2337/diabetes.51.6.1825
   Dochertyl JJ, 2007, J ANTIMICROB CHEMOTH, V59, P1182, DOI 10.1093/jac/dkm099
   DRENO B, 1989, ACTA DERM-VENEREOL, V69, P541
   De Sousa ICVD, 2019, EXPERT OPIN PHARMACO, V20, P1009, DOI 10.1080/14656566.2019.1584182
   El-akawi Z, 2006, CLIN EXP DERMATOL, V31, P430, DOI 10.1111/j.1365-2230.2006.02106.x
   Emiroglu N, 2015, POSTEP DERM ALERGOL, V32, P281, DOI 10.5114/pdia.2015.53047
   Fabbrocini G, 2016, CLIN EXP DERMATOL, V41, P38, DOI 10.1111/ced.12673
   FITZHERBERT JC, 1977, MED J AUSTRALIA, V2, P685
   Gabaton N.A., 2019, JPDS, V29, P20
   GARG A, 1992, DIABETES, V41, P1278, DOI 10.2337/diabetes.41.10.1278
   Gawecki J., 2011, ZYWIENIE CZLOWIEKA
   Glevitzky I, 2019, REV CHIM-BUCHAREST, V70, P3103
   Gollnick H, 2003, DRUGS, V63, P1579, DOI 10.2165/00003495-200363150-00005
   Gollnick HPM, 2008, AM J CLIN DERMATOL, V9, P279, DOI 10.2165/00128071-200809050-00001
   GORANSSON K, 1978, ACTA DERM-VENEREOL, V58, P443
   Grattagliano I, 2008, J NUTR BIOCHEM, V19, P491, DOI 10.1016/j.jnutbio.2007.06.011
   Gueniche A, 2010, EUR J DERMATOL, V20, P731, DOI 10.1684/ejd.2010.1108
   Gurumurthi R., 2004, ANTISEPTIC, V101, P249
   Haider A, 2004, JAMA-J AM MED ASSOC, V292, P726, DOI 10.1001/jama.292.6.726
   HAKANSON R, 1963, ACTA DERM-VENEREOL, V43, P552
   HILLSTROM L, 1977, BRIT J DERMATOL, V97, P679, DOI 10.1111/j.1365-2133.1977.tb14277.x
   HITCH JM, 1961, ARCH DERMATOL, V84, P898, DOI 10.1001/archderm.1961.01580180014002
   HITCH JM, 1967, J AMER MED ASSOC, V200, P879, DOI 10.1001/jama.200.10.879
   Hu Y, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00788
   Ismail NH, 2012, BMC DERMATOL, V12, DOI 10.1186/1471-5945-12-13
   Itoi S, 2013, BIOCHEM BIOPH RES CO, V440, P265, DOI 10.1016/j.bbrc.2013.09.065
   Jain A, 2003, PHYTOMEDICINE, V10, P34, DOI 10.1078/094471103321648638
   Jiang H, 2015, J DERMATOL, V42, P296, DOI 10.1111/1346-8138.12761
   Joo SS, 2008, PHYTOTHER RES, V22, P335, DOI 10.1002/ptr.2319
   Jung GW, 2013, J CUTAN MED SURG, V17, P114, DOI 10.2310/7750.2012.12026
   Kamezaki F, 2010, HYPERTENS RES, V33, P568, DOI 10.1038/hr.2010.32
   Karadag AS, 2018, CLIN DERMATOL, V36, P1, DOI [10.1016/j.clindermato1.2017.09.001, 10.1016/j.clindermatol.2017.09.001]
   Kaymak Y, 2007, J AM ACAD DERMATOL, V57, P819, DOI 10.1016/j.jaad.2007.06.028
   Kim H, 2017, ANN DERMATOL, V29, P20, DOI 10.5021/ad.2017.29.1.20
   KLIGMAN AM, 1981, INT J DERMATOL, V20, P278, DOI 10.1111/j.1365-4362.1981.tb04338.x
   Kober Mary-Margaret, 2015, Int J Womens Dermatol, V1, P85, DOI 10.1016/j.ijwd.2015.02.001
   Kolodziejczyk B, 2000, FERTIL STERIL, V73, P1149, DOI 10.1016/S0015-0282(00)00501-X
   KRAEGEN EW, 1991, DIABETES, V40, P1397, DOI 10.2337/diabetes.40.11.1397
   Kraft K., 2007, Z PHYTOTHER, V28, P129
   Kumari R, 2013, INDIAN J DERMATOL VE, V79, P291, DOI 10.4103/0378-6323.110753
   Kuznitzky E, 1913, ARCH DERMATOL SYPH-G, V114, P691, DOI 10.1007/BF01829693
   Lalla JK, 2001, J ETHNOPHARMACOL, V78, P99, DOI 10.1016/S0378-8741(01)00323-3
   Lee YB, 2019, J CLIN MED, V8, DOI 10.3390/jcm8070987
   Leyden JJ, 1997, NEW ENGL J MED, V336, P1156, DOI 10.1056/NEJM199704173361607
   Liao S., 2001, Hong Kong Medical Journal, V7, P369
   LIDEN S, 1980, ACTA DERM-VENEREOL, P47
   Lindeberg SA, 1999, METABOLISM, V48, P1216, DOI 10.1016/S0026-0495(99)90258-5
   Lovejoy JC, 2002, DIABETES CARE, V25, P1283, DOI 10.2337/diacare.25.8.1283
   Lovejoy JC, 2001, METABOLISM, V50, P86, DOI 10.1053/meta.2001.19440
   Lovejoy JC, 1998, METABOLISM, V47, P1520, DOI 10.1016/S0026-0495(98)90080-4
   Lovejoy Jennifer C, 2002, Curr Diab Rep, V2, P435, DOI 10.1007/s11892-002-0098-y
   LUCKY AW, 1995, AM J MED, V98, pS89, DOI 10.1016/S0002-9343(99)80064-3
   MACDONALD I, 1968, J SCI FOOD AGR, V19, P270, DOI 10.1002/jsfa.2740190508
   Mackie B S, 1974, Australas J Dermatol, V15, P103, DOI 10.1111/j.1440-0960.1974.tb00543.x
   Magin PJ, 2006, COMPLEMENT THER MED, V14, P62, DOI 10.1016/j.ctim.2005.10.007
   Mahmood T, 2010, BOSNIAN J BASIC MED, V10, P260, DOI 10.17305/bjbms.2010.2697
   Marcason Wendy, 2010, J Am Diet Assoc, V110, P152, DOI 10.1016/j.jada.2009.11.011
   Matsuzawa Y, 2008, INT J OBESITY, V32, pS83, DOI 10.1038/ijo.2008.243
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   Melnik BC, 2013, ACTA DERM-VENEREOL, V93, P644, DOI 10.2340/00015555-1677
   Melnik BC, 2012, DERM-ENDOCRINOL, V4, P20, DOI 10.4161/derm.19828
   Melnik BC, 2012, ACTA DERM-VENEREOL, V92, P228, DOI 10.2340/00015555-1358
   Melnik BC, 2009, MED HYPOTHESES, V72, P631, DOI 10.1016/j.mehy.2009.01.008
   Mena S, 2009, MUTAT RES-GEN TOX EN, V674, P36, DOI 10.1016/j.mrgentox.2008.09.017
   MICHAELSSON G, 1977, BRIT J DERMATOL, V97, P561, DOI 10.1111/j.1365-2133.1977.tb14136.x
   MICHAELSSON G, 1977, ARCH DERMATOL, V113, P31, DOI 10.1001/archderm.113.1.31
   MICHAELSSON G, 1977, BRIT J DERMATOL, V96, P283, DOI 10.1111/j.1365-2133.1977.tb06138.x
   MICHAELSSON G, 1984, ACTA DERM-VENEREOL, V64, P9
   Mottin VHM, 2018, INT J DERMATOL, V57, P1425, DOI 10.1111/ijd.13972
   Muizzuddin N, 2012, J COSMET SCI, V63, P385
   Muurling M, 2002, METABOLISM, V51, P695, DOI 10.1053/meta.2002.32725
   Nakatsuji T, 2008, J INVEST DERMATOL, V128, P2451, DOI 10.1038/jid.2008.117
   Nand P., 2012, Indian Journal of Natural Products and Resources, V3, P28
   Narahari S, 2012, GIORN ITAL DERMAT V, V147, P227
   Nasri H, 2015, JUNDISHAPUR J MICROB, V8, DOI 10.5812/jjm.25580
   Newgard CB, 2009, CELL METAB, V9, P311, DOI 10.1016/j.cmet.2009.02.002
   Notay M, 2017, AM J CLIN DERMATOL, V18, P721, DOI 10.1007/s40257-017-0300-2
   Oh S, 2006, FOOD CHEM TOXICOL, V44, P552, DOI 10.1016/j.fct.2005.08.030
   Oh TH, 2009, J GEN APPL MICROBIOL, V55, P63, DOI 10.2323/jgam.55.63
   Oprea OB, 2018, REV CHIM-BUCHAREST, V69, P70, DOI 10.37358/rc.18.1.6046
   ORRIS L, 1978, ARCH DERMATOL, V114, P1018, DOI 10.1001/archderm.114.7.1018
   Panichayupakaranant P, 2010, FOOD CHEM, V123, P400, DOI 10.1016/j.foodchem.2010.04.054
   Pappas A, 2002, J INVEST DERMATOL, V118, P164, DOI 10.1046/j.0022-202x.2001.01612.x
   PARK RG, 1968, BRIT J DERMATOL, V80, P758, DOI 10.1111/j.1365-2133.1968.tb11941.x
   Park SB, 2016, J PHARMACOL SCI, V131, P241, DOI 10.1016/j.jphs.2016.07.003
   PARKER DR, 1993, AM J CLIN NUTR, V58, P129, DOI 10.1093/ajcn/58.2.129
   Peirce A, 1999, AM PHARM ASS PRACTIC
   PENNINGTON JAT, 1990, J DAIRY SCI, V73, P3421, DOI 10.3168/jds.S0022-0302(90)79039-X
   Pithayanukul P, 2007, PHYTOTHER RES, V21, P164, DOI 10.1002/ptr.2048
   Plewig G, 2012, Acne and Rosacea, V3rd
   POCHI PE, 1970, J INVEST DERMATOL, V55, P303, DOI 10.1111/1523-1747.ep12260136
   Pothitirat W, 2010, MED PRIN PRACT, V19, P281, DOI 10.1159/000312714
   Prodanowich S, 2005, J AM ACAD DERMATOL, V52, P262, DOI 10.1016/j.jaad.2004.06.017
   Qa'dan F, 2005, AM J CHINESE MED, V33, P197, DOI 10.1142/S0192415X05002783
   Rasmussen LB, 2000, EUR J CLIN NUTR, V54, P57, DOI 10.1038/sj.ejcn.1600893
   Rasouli N, 2008, J CLIN ENDOCR METAB, V93, pS64, DOI 10.1210/jc.2008-1613
   RATNAM AV, 1979, BRIT J DERMATOL, V101, P449, DOI 10.1111/j.1365-2133.1979.tb00025.x
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Roberts CK, 2001, HYPERTENSION, V37, P1323, DOI 10.1161/01.HYP.37.5.1323
   ROBINSON H M, 1949, South Med J, V42, P1050
   Robinson S, 2019, DERMATOL THER, V32, DOI 10.1111/dth.12953
   Rodondi N, 2002, ANN INTERN MED, V136, P582, DOI 10.7326/0003-4819-136-8-200204160-00007
   Roth JL, 2002, NUTR REV, V60, P335
   Rubin MG, 2008, LIPIDS HEALTH DIS, V7, DOI 10.1186/1476-511X-7-36
   Salem I, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01459
   Sato T, 2007, J INVEST DERMATOL, V127, P2740, DOI 10.1038/sj.jid.5700927
   Schaefer O., 1971, Nutr Today, V6, P8
   Serrati B., 1938, RIV 5 NERV, V52, P377
   Sharma M, 2011, PHYTOTHER RES, V25, P517, DOI 10.1002/ptr.3288
   Sharma Shilpi, 2019, J Clin Aesthet Dermatol, V12, P34
   Siver R H., 1961, J Med Soc New Jersey, V59, P52
   Slobodníková L, 2004, PHYTOTHER RES, V18, P674, DOI 10.1002/ptr.1517
   Smith R, 2008, MOL NUTR FOOD RES, V52, P718, DOI 10.1002/mnfr.200700307
   Smith RN, 2007, J AM ACAD DERMATOL, V57, P247, DOI 10.1016/j.jaad.2007.01.046
   Spencer EH, 2009, INT J DERMATOL, V48, P339, DOI 10.1111/j.1365-4632.2009.04002.x
   Stefanadi EC, 2018, DIABETOL METAB SYNDR, V10, DOI 10.1186/s13098-018-0311-z
   Storlien L.H., 1993, ANN NY ACAD SCI, V683, P82
   Taniguchi CM, 2006, NAT REV MOL CELL BIO, V7, P85, DOI 10.1038/nrm1837
   Thiboutot DM, 2002, ARCH DERMATOL, V138, P1591, DOI 10.1001/archderm.138.12.1591
   Vandenplas Y, 2011, J PEDIAT-BRAZIL, V87, P292, DOI 10.2223/JPED.2103
   VERHAGEN AR, 1968, ARCH DERMATOL, V98, P577, DOI 10.1001/archderm.98.6.577
   VERMA KC, 1980, ACTA DERM-VENEREOL, V60, P337, DOI 10.2340/0001555560337340
   Vijayalakshmi A., 2011, International Journal of PharmTech Research, V3, P320
   Wang Y, 2002, ENDOCRINE, V17, P185, DOI 10.1385/ENDO:17:3:185
   Wang YH, 2014, APPL MICROBIOL BIOT, V98, P411, DOI 10.1007/s00253-013-5394-8
   Weckesser S, 2007, PHYTOMEDICINE, V14, P508, DOI 10.1016/j.phymed.2006.12.013
   Weichert S, 2012, PEDIATR INFECT DIS J, V31, P859, DOI 10.1097/INF.0b013e3182620e52
   WEIMAR VM, 1978, ARCH DERMATOL, V114, P1776, DOI 10.1001/archderm.114.12.1776
   Wilson PWF, 2005, CIRCULATION, V112, P3066, DOI 10.1161/CIRCULATIONAHA.105.539528
   Wold AE, 1998, ALLERGY, V53, P20, DOI 10.1111/j.1398-9995.1998.tb04953.x
   Wolf R, 2004, CLIN DERMATOL, V22, P387, DOI 10.1016/j.clindermatol.2004.03.007
   Zaba LC, 2007, J EXP MED, V204, P3183, DOI 10.1084/jem.20071094
   ZECH LA, 1983, ARCH DERMATOL, V119, P987, DOI 10.1001/archderm.119.12.987
   Zouboulis CC, 2014, CLIN DERMATOL, V32, P389, DOI 10.1016/j.clindermatol.2013.11.005
NR 176
TC 7
Z9 7
U1 1
U2 30
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD MAY 15
PY 2022
VL 923
AR 174936
DI 10.1016/j.ejphar.2022.174936
EA APR 2022
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 1W7GB
UT WOS:000806938300004
PM 35378101
DA 2025-06-11
ER

PT S
AU Chung, HS
   Choi, KM
AF Chung, Hye Soo
   Choi, Kyung Mook
BE Makowski, GS
TI Organokines in disease
SO ADVANCES IN CLINICAL CHEMISTRY, VOL 94
SE Advances in Clinical Chemistry
LA English
DT Review; Book Chapter
ID NONALCOHOLIC FATTY LIVER; GROWTH-FACTOR 21; ACTIVATED PROTEIN-KINASE;
   HIGH-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; MOLECULAR-WEIGHT
   ADIPONECTIN; MESSENGER-RNA EXPRESSION; HUMAN SKELETAL-MUSCLE; PLASMA
   FETUIN-A; ALPHA(2)-HEREMANS-SCHMID GLYCOPROTEIN/FETUIN-A
AB Studies have linked obesity, metabolic syndrome, type 2 diabetes, cardiovascular disease (CVD), nonalcoholic fatty liver disease (NAFLD) and dementia. Their relationship to the incidence and progression of these disease states suggests an interconnected pathogenesis involving chronic low-grade inflammation and oxidative stress. Metabolic syndrome represents comorbidities of central obesity, insulin resistance, dyslipidemia, hypertension and hyperglycemia associated with increased risk of type 2 diabetes, NAFLD, atherosclerotic CVD and neurodegenerative disease. As the socioeconomic burden for these diseases has grown signficantly with an increasing elderly population, new and alternative pharmacologic solutions for these cardiometabolic diseases are required. Adipose tissue, skeletal muscle and liver are central endocrine organs that regulate inflammation, energy and metabolic homeostasis, and the neuroendocrine axis through synthesis and secretion of adipokines, myokines, and hepatokines, respectively. These organokines affect each other and communicate through various endocrine, paracrine and autocrine pathways. The ultimate goal of this review is to provide a comprehensive understanding of organ crosstalk. This will include the roles of novel organokines in normal physiologic regulation and their pathophysiological effect in obesity, metabolic syndrome, type 2 diabetes, CVD, NAFLD and neurodegenerative disorders.
C1 [Chung, Hye Soo] Hallym Univ, Coll Med, Dept Internal Med, Div Endocrinol & Metab, Seoul, South Korea.
   [Choi, Kyung Mook] Korea Univ, Coll Med, Dept Internal Med, Div Endocrinol & Metab, Seoul, South Korea.
C3 Hallym University; Korea University; Korea University Medicine (KU
   Medicine)
RP Choi, KM (corresponding author), Korea Univ, Coll Med, Dept Internal Med, Div Endocrinol & Metab, Seoul, South Korea.
EM medica7@gmail.com
RI Choi, Kyung/C-4195-2018; Chung, Hye/AAG-8591-2020
OI Choi, Kyung Mook/0000-0001-6175-0225
FU Korea University Research Fund [B1901301]
FX This work was supported by the Korea University Research Fund
   (B1901301).
CR Achari AE, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18061321
   Achari AE, 2016, MOL CELL BIOCHEM, V414, P105, DOI 10.1007/s11010-016-2664-7
   Agata J, 1997, AM J HYPERTENS, V10, P1171
   Ahima RS, 2007, GASTROENTEROLOGY, V132, P444, DOI 10.1053/j.gastro.2006.11.048
   Ahima RS, 1999, ENDOCRINOLOGY, V140, P2755, DOI 10.1210/en.140.6.2755
   Ahmed A, 2015, CLIN GASTROENTEROL H, V13, P2062, DOI 10.1016/j.cgh.2015.07.029
   Al Hazzouri AZ, 2013, J GERONTOL A-BIOL, V68, P175, DOI 10.1093/gerona/gls155
   Albrecht E, 2015, SCI REP-UK, V5, DOI 10.1038/srep08889
   Alisi A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0067160
   Anstey KJ, 2017, J ALZHEIMERS DIS, V56, P215, DOI 10.3233/JAD-160826
   Antuna-Puente B, 2008, DIABETES METAB, V34, P2, DOI 10.1016/j.diabet.2007.09.004
   Arita Y, 1999, BIOCHEM BIOPH RES CO, V257, P79, DOI 10.1006/bbrc.1999.0255
   Arnoldussen IAC, 2014, EUR NEUROPSYCHOPHARM, V24, P1982, DOI 10.1016/j.euroneuro.2014.03.002
   Aronis KN, 2015, INT J OBESITY, V39, P156, DOI 10.1038/ijo.2014.101
   Asadi Y, 2018, NEUROCHEM RES, V43, P1549, DOI 10.1007/s11064-018-2569-9
   Aydin S, 2014, PEPTIDES, V61, P130, DOI 10.1016/j.peptides.2014.09.014
   Aydin S, 2014, PEPTIDES, V56, P94, DOI 10.1016/j.peptides.2014.03.021
   Badman MK, 2007, CELL METAB, V5, P426, DOI 10.1016/j.cmet.2007.05.002
   Badman MK, 2009, ENDOCRINOLOGY, V150, P4931, DOI 10.1210/en.2009-0532
   Barba G, 2003, OBES RES, V11, P160, DOI 10.1038/oby.2003.25
   Batirel S, 2014, FREE RADICAL BIO MED, V75, pS16, DOI 10.1016/j.freeradbiomed.2014.10.592
   Bell C, 2001, J CLIN ENDOCR METAB, V86, P4440, DOI 10.1210/jc.86.9.4440
   Berg AH, 2001, NAT MED, V7, P947, DOI 10.1038/90992
   Bigalke B, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020286
   Bjorbæk C, 2004, RECENT PROG HORM RES, V59, P305, DOI 10.1210/rp.59.1.305
   Blüher M, 2012, DIABETES METAB J, V36, P317, DOI 10.4093/dmj.2012.36.5.317
   BlumDegen D, 1995, NEUROSCI LETT, V202, P17, DOI 10.1016/0304-3940(95)12192-7
   Boström P, 2012, NATURE, V481, P463, DOI 10.1038/nature10777
   Bouret SG, 2010, BRAIN RES, V1350, P2, DOI 10.1016/j.brainres.2010.04.011
   Brechue WF, 1996, CLIN GERIATR MED, V12, P207, DOI 10.1016/S0749-0690(18)30254-4
   Brown R, 2007, NEUROENDOCRINOLOGY, V85, P232, DOI 10.1159/000104248
   Bugianesi E, 2005, AM J GASTROENTEROL, V100, P1082, DOI 10.1111/j.1572-0241.2005.41583.x
   Bugianesi E, 2005, J CLIN ENDOCR METAB, V90, P3498, DOI 10.1210/jc.2004-2240
   Burguera B, 2000, NEUROENDOCRINOLOGY, V71, P187, DOI 10.1159/000054536
   Burguera B, 2000, DIABETES, V49, P1219, DOI 10.2337/diabetes.49.7.1219
   Businaro Rita, 2012, Curr Gerontol Geriatr Res, V2012, P986823, DOI 10.1155/2012/986823
   Carey AL, 2006, DIABETES, V55, P2688, DOI 10.2337/db05-1404
   Carlyle M, 2002, HYPERTENSION, V39, P496, DOI 10.1161/hy0202.104398
   Caro JF, 1996, LANCET, V348, P159, DOI 10.1016/S0140-6736(96)03173-X
   Carter-Kent C, 2008, AM J GASTROENTEROL, V103, P1036, DOI 10.1111/j.1572-0241.2007.01709.x
   Chan DC, 2005, CLIN CHEM, V51, P578, DOI 10.1373/clinchem.2004.045120
   Chavez AO, 2009, DIABETES CARE, V32, P1542, DOI 10.2337/dc09-0684
   Chen S, 2019, REDOX BIOL, V22, DOI 10.1016/j.redox.2019.101133
   Chen ZY, 2001, CURR PROTEIN PEPT SC, V2, P261, DOI 10.2174/1389203013381125
   Choi HY, 2014, J CLIN ENDOCR METAB, V99, P2778, DOI 10.1210/jc.2014-1195
   Choi HY, 2011, ARTERIOSCL THROM VAS, V31, P944, DOI 10.1161/ATVBAHA.110.220673
   Choi KM, 2004, CLIN ENDOCRINOL, V61, P75, DOI 10.1111/j.1365-2265.2004.02063.x
   Choi KM, 2016, ENDOCRINOL METAB, V31, P1, DOI 10.3803/EnM.2016.31.1.1
   Choi KM, 2013, CLIN ENDOCRINOL, V79, P356, DOI 10.1111/cen.12076
   Choi SY, 2009, AM J GASTROENTEROL, V104, P1953, DOI 10.1038/ajg.2009.238
   Choi YK, 2013, DIABETES RES CLIN PR, V100, P96, DOI 10.1016/j.diabres.2013.01.007
   Chow WS, 2013, ARTERIOSCL THROM VAS, V33, P2454, DOI 10.1161/ATVBAHA.113.301599
   Christou GA, 2012, HORM-INT J ENDOCRINO, V11, P178, DOI 10.14310/horm.2002.1345
   Chrusciel P, 2016, ATHEROSCLEROSIS, V253, P194, DOI 10.1016/j.atherosclerosis.2016.07.897
   Chung HS, 2018, INT J ENDOCRINOL, V2018, DOI 10.1155/2018/7918714
   Chung HS, 2018, J GERONTOL A-BIOL, V73, P386, DOI 10.1093/gerona/glx055
   Church RM, 2014, BEHAV NEUROSCI, V128, P523, DOI 10.1037/a0036433
   Cinti S, 1997, ENDOCRINOLOGY, V138, P797, DOI 10.1210/en.138.2.797
   Colcombe SJ, 2003, J GERONTOL A-BIOL, V58, P176
   COLEMAN DL, 1973, DIABETOLOGIA, V9, P294, DOI 10.1007/BF01221857
   Combs TP, 2014, REV ENDOCR METAB DIS, V15, P137, DOI 10.1007/s11154-013-9280-6
   Combs TP, 2002, ENDOCRINOLOGY, V143, P998, DOI 10.1210/en.143.3.998
   Correia MLG, 2001, HYPERTENSION, V37, P936, DOI 10.1161/01.HYP.37.3.936
   Cotman CW, 2007, TRENDS NEUROSCI, V30, P464, DOI 10.1016/j.tins.2007.06.011
   Cressman DE, 1996, SCIENCE, V274, P1379, DOI 10.1126/science.274.5291.1379
   CRETTAZ M, 1983, AM J PHYSIOL, V244, pE414, DOI 10.1152/ajpendo.1983.244.4.E414
   Nascimento CMC, 2015, J ALZHEIMERS DIS, V43, P81, DOI 10.3233/JAD-140576
   D'souza AM, 2017, MOL METAB, V6, P1052, DOI 10.1016/j.molmet.2017.04.011
   Dabrowska AM, 2015, BIOMED PAP, V159, P352, DOI 10.5507/bp.2015.018
   DAVEAU M, 1990, FEBS LETT, V273, P79, DOI 10.1016/0014-5793(90)81055-S
   DAVEAU M, 1988, FEBS LETT, V241, P191, DOI 10.1016/0014-5793(88)81059-7
   de Chantemèle EJB, 2017, ADV EXP MED BIOL, V1043, P87, DOI 10.1007/978-3-319-70178-3_6
   DeFronzo RA, 2009, DIABETES CARE, V32, pS157, DOI 10.2337/dc09-S302
   Delgado TC, 2011, J CEREBR BLOOD F MET, V31, P2257, DOI 10.1038/jcbfm.2011.134
   Diniz BS, 2011, NEUROMOL MED, V13, P217, DOI 10.1007/s12017-011-8154-x
   Domingo P, 2010, AIDS, V24, P2629, DOI 10.1097/QAD.0b013e3283400088
   Dushay J, 2010, GASTROENTEROLOGY, V139, P456, DOI 10.1053/j.gastro.2010.04.054
   Dutchak PA, 2012, CELL, V148, P556, DOI 10.1016/j.cell.2011.11.062
   Ekstedt M, 2015, HEPATOLOGY, V61, P1547, DOI 10.1002/hep.27368
   Ellingsgaard H, 2011, NAT MED, V17, P1481, DOI 10.1038/nm.2513
   Erden Y, 2016, NEUROSCI LETT, V618, P6, DOI 10.1016/j.neulet.2016.02.046
   Erta M, 2012, INT J BIOL SCI, V8, P1254, DOI 10.7150/ijbs.4679
   Ezaki H, 2009, BIOCHEM BIOPH RES CO, V378, P68, DOI 10.1016/j.bbrc.2008.10.176
   Fantuzzi G, 2005, J ALLERGY CLIN IMMUN, V115, P911, DOI 10.1016/j.jaci.2005.02.023
   Farooqi IS, 1999, NEW ENGL J MED, V341, P879, DOI 10.1056/NEJM199909163411204
   Farooqi IS, 2002, J CLIN INVEST, V110, P1093, DOI 10.1172/JCI200215693
   Farr SA, 2006, PEPTIDES, V27, P1420, DOI 10.1016/j.peptides.2005.10.006
   Fei H, 1997, P NATL ACAD SCI USA, V94, P7001, DOI 10.1073/pnas.94.13.7001
   Fischer CP, 2004, AM J PHYSIOL-ENDOC M, V287, pE1189, DOI 10.1152/ajpendo.00206.2004
   Fisher FM, 2012, GENE DEV, V26, P271, DOI 10.1101/gad.177857.111
   Fraga VG, 2015, ARQ NEURO-PSIQUIAT, V73, P899, DOI 10.1590/0004-282X20150137
   Friedman JM, 1998, NATURE, V395, P763, DOI 10.1038/27376
   Fruebis J, 2001, P NATL ACAD SCI USA, V98, P2005, DOI 10.1073/pnas.041591798
   Frühbeck G, 2006, BIOCHEM J, V393, P7, DOI 10.1042/BJ20051578
   Fujikawa T, 2015, FRONT NEUROSCI-SWITZ, V9, DOI 10.3389/fnins.2015.00108
   Fujikawa T, 2013, CELL METAB, V18, P431, DOI 10.1016/j.cmet.2013.08.004
   Fukushima J, 2009, HEPATOL RES, V39, P724, DOI 10.1111/j.1872-034X.2009.00509.x
   Gaich G, 2013, CELL METAB, V18, P333, DOI 10.1016/j.cmet.2013.08.005
   Garvey WT, 2018, METABOLISM, V85, P32, DOI 10.1016/j.metabol.2018.02.002
   Gatselis NK, 2014, CLIN EXP MED, V14, P121, DOI 10.1007/s10238-012-0227-0
   Ghadge AA, 2017, DIABETES METAB SYND, V11, pS481, DOI 10.1016/j.dsx.2017.03.041
   Gleeson M, 2000, J PHYSIOL-LONDON, V529, P1, DOI 10.1111/j.1469-7793.2000.00001.x
   Gorska-Ciebiada M, 2016, METAB BRAIN DIS, V31, P257, DOI 10.1007/s11011-015-9739-0
   Grundy SM, 2004, CIRCULATION, V109, P551, DOI 10.1161/01.CIR.0000112379.88385.67
   Gu YA, 2010, J ALZHEIMERS DIS, V22, P483, DOI 10.3233/JAD-2010-100897
   Gustafson D, 2006, LANCET NEUROL, V5, P713, DOI 10.1016/S1474-4422(06)70526-9
   Gustafson DR, 2012, ALZHEIMERS DEMENT, V8, P272, DOI 10.1016/j.jalz.2011.05.2411
   Haltia LT, 2007, J CLIN ENDOCR METAB, V92, P3278, DOI 10.1210/jc.2006-2495
   Hamirani Yasmin S, 2014, J Clin Exp Cardiolog, V5
   Han TS, 2016, JRSM CARDIOVASC DIS, V5, DOI 10.1177/2048004016633371
   Hashemi MS, 2013, NEUROSCIENCE, V231, P296, DOI 10.1016/j.neuroscience.2012.11.041
   Haukeland JW, 2012, EUR J ENDOCRINOL, V166, P503, DOI 10.1530/EJE-11-0864
   Havel PJ, 2004, DIABETES, V53, pS143, DOI 10.2337/diabetes.53.2007.S143
   Hecksteden A, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-235
   Hennige AM, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001765
   Hirano T, 1998, Int Rev Immunol, V16, P249
   Hirose H, 1998, J HYPERTENS, V16, P2007, DOI 10.1097/00004872-199816121-00023
   Hojman P, 2009, DIABETES, V58, P2797, DOI 10.2337/db09-0713
   Holden KF, 2009, NEUROBIOL AGING, V30, P1483, DOI 10.1016/j.neurobiolaging.2007.11.024
   Hondares E, 2011, J BIOL CHEM, V286, P12983, DOI 10.1074/jbc.M110.215889
   Hong HC, 2014, HEPATOLOGY, V59, P1772, DOI 10.1002/hep.26716
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Hsuchou H, 2007, PEPTIDES, V28, P2382, DOI 10.1016/j.peptides.2007.10.007
   Hu LJ, 2017, ONCOTARGET, V8, P88008, DOI 10.18632/oncotarget.21330
   Huby AC, 2015, CIRCULATION, V132, P2134, DOI 10.1161/CIRCULATIONAHA.115.018226
   Hug C, 2004, P NATL ACAD SCI USA, V101, P10308, DOI 10.1073/pnas.0403382101
   Huh JY, 2014, INT J OBESITY, V38, P1538, DOI 10.1038/ijo.2014.42
   Huh JY, 2014, J CLIN ENDOCR METAB, V99, pE2154, DOI 10.1210/jc.2014-1437
   Huh JY, 2012, METABOLISM, V61, P1725, DOI 10.1016/j.metabol.2012.09.002
   Hui JM, 2004, HEPATOLOGY, V40, P46, DOI 10.1002/hep.20280
   Iizuka K, 2009, FEBS LETT, V583, P2882, DOI 10.1016/j.febslet.2009.07.053
   Ikonomidis I, 2014, CIRC-CARDIOVASC IMAG, V7, P619, DOI 10.1161/CIRCIMAGING.113.001193
   Imajo K, 2012, CELL METAB, V16, P44, DOI 10.1016/j.cmet.2012.05.012
   Inoue K, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0077118
   International Diabetes Federation, 2006, IDF CONS WORLDW DEF
   Iroz A, 2015, DIABETOLOGIA, V58, P1699, DOI 10.1007/s00125-015-3634-4
   Iwabu M, 2010, NATURE, V464, P1313, DOI 10.1038/nature08991
   Ix JH, 2006, CIRCULATION, V113, P1760, DOI 10.1161/CIRCULATIONAHA.105.588723
   Janssen I, 2000, J APPL PHYSIOL, V89, P81
   Jarrar MH, 2008, ALIMENT PHARM THER, V27, P412, DOI 10.1111/j.1365-2036.2007.03586.x
   Jedrychowski MP, 2015, CELL METAB, V22, P734, DOI 10.1016/j.cmet.2015.08.001
   Jensen MK, 2013, DIABETES CARE, V36, P1222, DOI 10.2337/dc12-1591
   Jiang S, 2014, J NUTRIGENET NUTRIGE, V7, P121, DOI 10.1159/000367943
   Jiang S, 2014, J BIOL CHEM, V289, P29751, DOI 10.1074/jbc.M114.565960
   Jin L, 2000, ENDOCRINOLOGY, V141, P333, DOI 10.1210/en.141.1.333
   Kadowaki T, 2006, J CLIN INVEST, V116, P1784, DOI 10.1172/JCI29126
   Kalabay L, 1997, J HEPATOL, V26, P1426, DOI 10.1016/S0168-8278(97)80483-7
   Kalabay L, 2002, EUR J GASTROEN HEPAT, V14, P389, DOI 10.1097/00042737-200204000-00009
   Kamimura D, 2004, REV PHYSIOL BIOCH P, V149, P1, DOI 10.1007/s10254-003-0012-2
   Kamohara S, 1997, NATURE, V389, P374, DOI 10.1038/38717
   Kantartzis K, 2010, DIABETOLOGIA, V53, P882, DOI 10.1007/s00125-010-1663-6
   Kaser S, 2005, J INTERN MED, V258, P274, DOI 10.1111/j.1365-2796.2005.01543.x
   Kazumi T, 2004, METABOLISM, V53, P589, DOI 10.1016/j.metabol.2003.12.008
   Keller C, 2005, J APPL PHYSIOL, V99, P2075, DOI 10.1152/japplphysiol.00590.2005
   Kelley DE, 2002, DIABETES, V51, P2944, DOI 10.2337/diabetes.51.10.2944
   Kelly M, 2004, BIOCHEM BIOPH RES CO, V320, P449, DOI 10.1016/j.bbrc.2004.05.188
   Kharitonenkov A, 2005, J CLIN INVEST, V115, P1627, DOI 10.1172/JCI23606
   Kharitonenkov A, 2009, CURR OPIN PHARMACOL, V9, P805, DOI 10.1016/j.coph.2009.07.001
   Khemka VK, 2014, J ALZHEIMERS DIS, V41, P525, DOI 10.3233/JAD-140006
   Kim TN, 2015, J CELL BIOCHEM, V116, P1171, DOI 10.1002/jcb.25077
   Kim TN, 2010, DIABETES CARE, V33, P1497, DOI 10.2337/dc09-2310
   Kitagawa K, 2016, EUR J NEUROL, V23, P641, DOI 10.1111/ene.12915
   Kitamura Y, 2017, NEUROL RES, V39, P231, DOI 10.1080/01616412.2017.1281195
   Kobashi C, 2005, CIRC RES, V97, P1245, DOI 10.1161/01.RES.0000194328.57164.36
   Kobayashi H, 2004, CIRC RES, V94, pE27, DOI 10.1161/01.RES.0000119921.86460.37
   Kobilo T, 2011, LEARN MEMORY, V18, P605, DOI 10.1101/lm.2283011
   Kojima S, 2003, HEART, V89, P667, DOI 10.1136/heart.89.6.667
   Krawczyk K, 2009, J PHYSIOL PHARMACOL, V60, P71
   Kriketos AD, 2004, DIABETES CARE, V27, P629, DOI 10.2337/diacare.27.2.629
   Kristiansen OP, 2005, DIABETES, V54, pS114, DOI 10.2337/diabetes.54.suppl_2.S114
   Kroy DC, 2010, HEPATOLOGY, V51, P463, DOI 10.1002/hep.23322
   Kurosu H, 2007, J BIOL CHEM, V282, P26687, DOI 10.1074/jbc.M704165200
   Laughlin GA, 2012, J AM COLL CARDIOL, V59, P1688, DOI 10.1016/j.jacc.2012.01.038
   Lebensztejn DM, 2014, ADV MED SCI-POLAND, V59, P81, DOI 10.1016/j.advms.2013.08.003
   Lee DV, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0111767
   Lee GH, 1996, NATURE, V379, P632, DOI 10.1038/379632a0
   Lee HJ, 2015, MOL ENDOCRINOL, V29, P873, DOI 10.1210/me.2014-1353
   Lee J, 2016, NAT MED, V22, P1023, DOI 10.1038/nm.4145
   Lee P, 2014, CELL METAB, V19, P302, DOI 10.1016/j.cmet.2013.12.017
   Letra L, 2019, FRONT NEUROENDOCRIN, V52, P1, DOI 10.1016/j.yfrne.2017.10.002
   Li DJ, 2017, METABOLISM, V68, P31, DOI 10.1016/j.metabol.2016.12.003
   Li HT, 2010, J HEPATOL, V53, P934, DOI 10.1016/j.jhep.2010.05.018
   Li J, 2005, CIRC RES, V97, P872, DOI 10.1161/01.RES.0000187458.77026.10
   Li J, 2012, INT J ENV RES PUB HE, V9, P391, DOI 10.3390/ijerph9020391
   Li M, 2017, FRONT CARDIOVASC MED, V4, DOI 10.3389/fcvm.2017.00051
   Li SS, 2009, JAMA-J AM MED ASSOC, V302, P179, DOI 10.1001/jama.2009.976
   Li Y, 2014, GASTROENTEROLOGY, V146, P539, DOI 10.1053/j.gastro.2013.10.059
   Licastro F, 2000, J NEUROIMMUNOL, V103, P97, DOI 10.1016/S0165-5728(99)00226-X
   Lieb W, 2009, JAMA-J AM MED ASSOC, V302, P2565, DOI 10.1001/jama.2009.1836
   Lin KH, 2003, J ENDOCRINOL, V179, P367, DOI 10.1677/joe.0.1790367
   Lin ZF, 2015, CIRCULATION, V131, P1861, DOI 10.1161/CIRCULATIONAHA.115.015308
   Lin ZF, 2013, CELL METAB, V17, P779, DOI 10.1016/j.cmet.2013.04.005
   Lin ZF, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0018398
   Littlejohns TJ, 2015, J ALZHEIMERS DIS, V44, P1231, DOI 10.3233/JAD-141836
   Liu JJ, 2013, J DIABETES COMPLICAT, V27, P365, DOI 10.1016/j.jdiacomp.2013.03.002
   Liu JL, 2015, CELL, V161, P999, DOI 10.1016/j.cell.2015.05.011
   Liu TY, 2015, CLIN SCI, V129, P839, DOI 10.1042/CS20150009
   Loddick SA, 1998, J CEREBR BLOOD F MET, V18, P176, DOI 10.1097/00004647-199802000-00008
   Longo FM, 2007, CURR ALZHEIMER RES, V4, P503, DOI 10.2174/156720507783018316
   Lowe G, 2014, DIABETES, V63, P1115, DOI 10.2337/db12-1625
   Lv J, 2015, HORM METAB RES, V47, P591, DOI 10.1055/s-0035-1547261
   Ma J, 2016, CURR ALZHEIMER RES, V13, P223, DOI 10.2174/156720501303160217111434
   Magalhaes CA, 2018, J CLIN NEUROSCI, V56, P150, DOI 10.1016/j.jocn.2018.08.027
   Magkos F, 2007, CURR OPIN CLIN NUTR, V10, P571, DOI 10.1097/MCO.0b013e3282bf6ea8
   Mantzoros Christos S, 2011, Am J Physiol Endocrinol Metab, V301, pE567, DOI 10.1152/ajpendo.00315.2011
   Mantzoros CS, 1998, CLIN ENDOCRINOL, V49, P551, DOI 10.1046/j.1365-2265.1998.00571.x
   Martínez M, 2000, BRAIN RES, V869, P216, DOI 10.1016/S0006-8993(00)02363-5
   Masuzaki H, 1997, NAT MED, V3, P1029, DOI 10.1038/nm0997-1029
   Mathews ST, 2002, DIABETES, V51, P2450, DOI 10.2337/diabetes.51.8.2450
   Matthews VB, 2010, DIABETOLOGIA, V53, P2431, DOI 10.1007/s00125-010-1865-y
   McGuire MJ, 2016, CELL MOL NEUROBIOL, V36, P203, DOI 10.1007/s10571-015-0282-7
   Meja KK, 1997, BRIT J PHARMACOL, V122, P149, DOI 10.1038/sj.bjp.0701360
   Messina G, 2013, NEUROL RES INT, V2013, DOI 10.1155/2013/639280
   Mittendorfer B, 2011, DIABETES, V60, P1474, DOI 10.2337/db10-1302
   Miwa K, 2016, EUR J NEUROL, V23, P656, DOI 10.1111/ene.12921
   Mix H, 2000, GUT, V47, P481, DOI 10.1136/gut.47.4.481
   Mogi M, 1996, NEUROSCI LETT, V211, P13, DOI 10.1016/0304-3940(96)12706-3
   MOGI M, 1994, NEUROSCI LETT, V180, P147, DOI 10.1016/0304-3940(94)90508-8
   Mohammadi-Sartang M, 2017, PHARMACOL RES, V117, P394, DOI 10.1016/j.phrs.2017.01.012
   MOINAT M, 1995, FEBS LETT, V373, P131, DOI 10.1016/0014-5793(95)01030-I
   Moon HS, 2013, METABOLISM, V62, P1131, DOI 10.1016/j.metabol.2013.04.007
   Moon HS, 2011, DIABETES, V60, P1647, DOI 10.2337/db10-1791
   Morash B, 1999, ENDOCRINOLOGY, V140, P5995, DOI 10.1210/en.140.12.5995
   Mori K, 2006, DIABETES CARE, V29, P468, DOI 10.2337/diacare.29.02.06.dc05-1484
   Morino K, 2006, DIABETES, V55, pS9, DOI 10.2337/db06-S002
   Morrice N, 2017, SCI REP-UK, V7, DOI 10.1038/srep43782
   Morrison CD, 2009, BBA-MOL BASIS DIS, V1792, P401, DOI 10.1016/j.bbadis.2008.12.004
   Müller TD, 2012, J PEPT SCI, V18, P383, DOI 10.1002/psc.2408
   Muise ES, 2008, MOL PHARMACOL, V74, P403, DOI 10.1124/mol.108.044826
   Mukhopadhyay S, 2016, DIABETOLOGIA, V59, P859, DOI 10.1007/s00125-016-3866-y
   Mukhopadhyay S, 2014, ENDOCR PRACT, V20, P1345, DOI 10.4158/EP14421.RA
   Musso G, 2015, TRENDS MOL MED, V21, P645, DOI 10.1016/j.molmed.2015.08.005
   Musso G, 2012, HEPATOLOGY, V56, DOI 10.1002/hep.25677
   Natalicchio A, 2017, DIABETES, V66, P2849, DOI 10.2337/db17-0002
   Nestel PJ, 2013, CURR OPIN LIPIDOL, V24, P1, DOI 10.1097/MOL.0b013e32835c0834
   Neumeier M, 2006, WORLD J GASTROENTERO, V12, P5490, DOI 10.3748/wjg.v12.i34.5490
   Ng RCL, 2016, MOL NEURODEGENER, V11, DOI 10.1186/s13024-016-0136-x
   Nie YW, 2017, BIOCHEM J, V474, P3167, DOI 10.1042/BCJ20170241
   Nieto-Vazquez I, 2008, DIABETES, V57, P3211, DOI 10.2337/db07-1062
   Nishimura T, 2000, BBA-GENE STRUCT EXPR, V1492, P203, DOI 10.1016/S0167-4781(00)00067-1
   Norheim F, 2014, FEBS J, V281, P739, DOI 10.1111/febs.12619
   Numao S, 2011, METABOLISM, V60, P186, DOI 10.1016/j.metabol.2009.12.011
   Oania R, 2015, AGE AGEING, V44, P53, DOI 10.1093/ageing/afu160
   Ochi A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0088704
   Ochiai H, 2008, ENDOCR J, V55, P549, DOI 10.1507/endocrj.K07E-107
   Ohashi K, 2009, MOL CELL BIOL, V29, P3487, DOI 10.1128/MCB.00126-09
   Okada-Iwabu M, 2013, NATURE, V503, P493, DOI 10.1038/nature12656
   OLEKSOWICZ L, 1994, THROMB HAEMOSTASIS, V72, P302
   Ong KL, 2015, DIABETOLOGIA, V58, P2035, DOI 10.1007/s00125-015-3652-2
   Oral EA, 2002, NEW ENGL J MED, V346, P570, DOI 10.1056/NEJMoa012437
   Ostrowski K, 1998, J PHYSIOL-LONDON, V508, P949, DOI 10.1111/j.1469-7793.1998.949bp.x
   Ou HY, 2011, CLIN ENDOCRINOL, V75, P450, DOI 10.1111/j.1365-2265.2011.04070.x
   Ouchi N, 2000, CIRCULATION, V102, P1296, DOI 10.1161/01.CIR.102.11.1296
   Ouchi N, 2001, CIRCULATION, V103, P1057, DOI 10.1161/01.CIR.103.8.1057
   Ouchi N, 1999, CIRCULATION, V100, P2473, DOI 10.1161/01.CIR.100.25.2473
   Ouchi N, 2006, TRENDS CARDIOVAS MED, V16, P141, DOI 10.1016/j.tcm.2006.03.001
   Ouchi N, 2011, NAT REV IMMUNOL, V11, P85, DOI 10.1038/nri2921
   Pajvani UB, 2004, J BIOL CHEM, V279, P12152, DOI 10.1074/jbc.M311113200
   Pan WH, 2001, LIFE SCI, V68, P2705, DOI 10.1016/S0024-3205(01)01085-2
   Pardo M, 2014, INT J ENDOCRINOL, V2014, DOI 10.1155/2014/857270
   Park CY, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-36581-z
   Park K.H., J CLIN ENDOCR METAB, V98
   Park KH, 2013, J CLIN ENDOCR METAB, V98, P4899, DOI 10.1210/jc.2013-2373
   Park MJ, 2015, CELL SIGNAL, V27, P1831, DOI 10.1016/j.cellsig.2015.04.010
   Paz G, 2010, INT J CLIN PRACT, V64, P1808, DOI 10.1111/j.1742-1241.2010.02536.x
   Paz-Filho G, 2010, ARQ BRAS ENDOCRINOL, V54, P690, DOI 10.1590/S0004-27302010000800005
   Pedersen BK, 2007, BIOCHEM SOC T, V35, P1295, DOI 10.1042/BST0351295
   Pedersen BK, 2011, J EXP BIOL, V214, P337, DOI 10.1242/jeb.048074
   Pedersen BK, 2006, SCAND J MED SCI SPOR, V16, P3, DOI 10.1111/j.1600-0838.2006.00520.x
   Petersen AMW, 2005, J APPL PHYSIOL, V98, P1154, DOI 10.1152/japplphysiol.00164.2004
   Petta S, 2017, J CLIN ENDOCR METAB, V102, P2660, DOI 10.1210/jc.2017-00056
   Phrommintikul A, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-23550-9
   Pischon T, 2004, JAMA-J AM MED ASSOC, V291, P1730, DOI 10.1001/jama.291.14.1730
   Planavila A, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3019
   Polyzos SA, 2016, DIABETOLOGIA, V59, P30, DOI 10.1007/s00125-015-3769-3
   Polyzos SA, 2015, ENDOCRINE, V49, P560, DOI 10.1007/s12020-014-0473-x
   Polyzos SA, 2015, METABOLISM, V64, P60, DOI 10.1016/j.metabol.2014.10.012
   Polyzos SA, 2011, METABOLISM, V60, P313, DOI 10.1016/j.metabol.2010.09.003
   Polyzos SA, 2009, CURR MOL MED, V9, P299, DOI 10.2174/156652409787847191
   Potthoff MJ, 2009, P NATL ACAD SCI USA, V106, P10853, DOI 10.1073/pnas.0904187106
   Puchades M, 2003, MOL BRAIN RES, V118, P140, DOI 10.1016/j.molbrainres.2003.08.005
   Puz P, 2017, ATHEROSCLEROSIS, V263, P97, DOI 10.1016/j.atherosclerosis.2017.06.008
   Qiu ZH, 2003, J NEUROIMMUNOL, V139, P51, DOI 10.1016/S0165-5728(03)00158-9
   Qu D, 2014, BRIT J PHARMACOL, V171, P3595, DOI 10.1111/bph.12713
   Reinehr T, 2008, J CLIN ENDOCR METAB, V93, P4479, DOI 10.1210/jc.2008-1505
   Richez C, 2012, J RHEUMATOL, V39, P1192, DOI 10.3899/jrheum.111439
   Rodríguez A, 2015, INT J OBESITY, V39, P397, DOI 10.1038/ijo.2014.166
   Sa-nguanmoo P, 2016, METAB BRAIN DIS, V31, P239, DOI 10.1007/s11011-015-9789-3
   Sabaratnam R, 2018, PHYSIOL REP, V6, DOI 10.14814/phy2.13723
   Sadik NAH, 2012, HUM EXP TOXICOL, V31, P311, DOI 10.1177/0960327111431091
   Sahebkar A, 2013, METABOLISM, V62, P1876, DOI 10.1016/j.metabol.2013.08.017
   Sahebkar A, 2013, ATHEROSCLEROSIS, V230, P110, DOI 10.1016/j.atherosclerosis.2013.06.026
   Santos-Lozano A, 2016, MAYO CLIN PROC, V91, P999, DOI 10.1016/j.mayocp.2016.04.024
   Saremi A, 2009, ATHEROSCLEROSIS, V203, P610, DOI 10.1016/j.atherosclerosis.2008.07.031
   Schäfer C, 2003, J CLIN INVEST, V112, P357, DOI 10.1172/JCI200317202
   SCHERER PE, 1995, J BIOL CHEM, V270, P26746, DOI 10.1074/jbc.270.45.26746
   Schmidt-Arras D, 2016, J HEPATOL, V64, P1403, DOI 10.1016/j.jhep.2016.02.004
   Schuitemaker A, 2009, NEUROBIOL AGING, V30, P1885, DOI 10.1016/j.neurobiolaging.2008.01.014
   Schulz C, 2010, RESULTS PROBL CELL D, V52, P189, DOI 10.1007/978-3-642-14426-4_16
   Shanaki M, 2017, DIABETES METAB SYND, V11, pS467, DOI 10.1016/j.dsx.2017.03.037
   Shen JY, 2012, J HEPATOL, V56, P1363, DOI 10.1016/j.jhep.2011.12.025
   Shen Y, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-124
   Shi XW, 2019, J ALZHEIMERS DIS, V68, P1667, DOI 10.3233/JAD-181218
   Shibata R, 2005, NAT MED, V11, P1096, DOI 10.1038/nm1295
   Shimomura I, 1999, NATURE, V401, P73, DOI 10.1038/43448
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Singh M, 2012, J PHARM PHARMACOL, V64, P1703, DOI 10.1111/j.2042-7158.2012.01561.x
   Sinha MK, 1996, J CLIN INVEST, V97, P1344, DOI 10.1172/JCI118551
   Smith ER, 2011, J ALZHEIMERS DIS, V24, P327, DOI 10.3233/JAD-2011-101872
   Smith-Kirwin SM, 1998, J CLIN ENDOCR METAB, V83, P1810, DOI 10.1210/jc.83.5.1810
   So WY, 2016, INT J BIOCHEM CELL B, V78, P237, DOI 10.1016/j.biocel.2016.07.022
   Song HB, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0110273
   Song J, 2015, CELL DEATH DIS, V6, DOI 10.1038/cddis.2015.220
   Song J, 2017, CELL DEATH DIS, V8, DOI 10.1038/cddis.2017.491
   Spranger J, 2003, LANCET, V361, P226, DOI 10.1016/S0140-6736(03)12255-6
   Spranger J, 2003, DIABETES, V52, P812, DOI 10.2337/diabetes.52.3.812
   SRINIVAS PR, 1993, MOL ENDOCRINOL, V7, P1445, DOI 10.1210/me.7.11.1445
   Steensberg A, 2001, J PHYSIOL-LONDON, V537, P633, DOI 10.1111/j.1469-7793.2001.00633.x
   Steensberg A, 2000, J PHYSIOL-LONDON, V529, P237, DOI 10.1111/j.1469-7793.2000.00237.x
   Stefan N, 2006, DIABETES CARE, V29, P853, DOI 10.2337/diacare.29.04.06.dc05-1938
   Stein CJ, 2004, J CLIN ENDOCR METAB, V89, P2522, DOI 10.1210/jc.2004-0288
   Stepanova M, 2012, CLIN GASTROENTEROL H, V10, P646, DOI 10.1016/j.cgh.2011.12.039
   Strobel A, 1998, NAT GENET, V18, P213, DOI 10.1038/ng0398-213
   Su JR, 2016, HORM METAB RES, V48, P92, DOI 10.1055/s-0035-1569287
   Sullivan PG, 2003, ANN NEUROL, V53, P711, DOI 10.1002/ana.10543
   Sun Q, 2013, DIABETES, V62, P49, DOI 10.2337/db12-0372
   Suzuki K, 2010, CLIN CHIM ACTA, V411, P1330, DOI 10.1016/j.cca.2010.05.029
   Swerdlow DI, 2012, LANCET, V379, P1214, DOI 10.1016/S0140-6736(12)60110-X
   Tacer KF, 2010, MOL ENDOCRINOL, V24, P2050, DOI 10.1210/me.2010-0142
   Takagi H, 2013, J AM SOC HYPERTENS, V7, P229, DOI 10.1016/j.jash.2013.02.006
   Talukdar S, 2016, CELL METAB, V23, P427, DOI 10.1016/j.cmet.2016.02.001
   Tanaka N, 2015, BBA-MOL BASIS DIS, V1852, P1242, DOI 10.1016/j.bbadis.2015.02.012
   Tang H, 2016, EBIOMEDICINE, V6, P139, DOI 10.1016/j.ebiom.2016.02.041
   Tank J, 2008, J CLIN ENDOCR METAB, V93, P4974, DOI 10.1210/jc.2007-2820
   Tao C, 2014, BEST PRACT RES CL EN, V28, P43, DOI 10.1016/j.beem.2013.11.003
   Tao L, 2007, CIRCULATION, V115, P1408, DOI 10.1161/CIRCULATIONAHA.106.666941
   Targher G, 2008, OBESITY, V16, P1394, DOI 10.1038/oby.2008.64
   Targher G, 2007, DIABETES CARE, V30, P1212, DOI 10.2337/dc06-2247
   Targher G, 2006, CLIN ENDOCRINOL, V64, P679, DOI 10.1111/j.1365-2265.2006.02527.x
   Tehrani DM, 2013, ATHEROSCLEROSIS, V231, P246, DOI 10.1016/j.atherosclerosis.2013.08.036
   Teixeira AL, 2013, NEUROMOL MED, V15, P115, DOI 10.1007/s12017-012-8201-2
   Terai K, 2005, MOL CELL BIOL, V25, P9554, DOI 10.1128/MCB.25.21.9554-9575.2005
   Teunissen CE, 2015, J ALZHEIMERS DIS, V44, P809, DOI 10.3233/JAD-141503
   Tietge UJF, 2004, AM J PHYSIOL-ENDOC M, V287, pE82, DOI 10.1152/ajpendo.00494.2003
   Timper K, 2017, CELL REP, V19, P267, DOI 10.1016/j.celrep.2017.03.043
   Tortelli R, 2017, J ALZHEIMERS DIS, V59, P121, DOI [10.3233/jad-170153, 10.3233/JAD-170153]
   Trepanowski J. F., 2015, International Journal of Obesity, V39, P734, DOI 10.1038/ijo.2014.203
   Tsuchiya Y, 2015, METABOLISM, V64, P1042, DOI 10.1016/j.metabol.2015.05.010
   Turer AT, 2012, J CLIN ENDOCR METAB, V97, pE982, DOI 10.1210/jc.2011-3305
   Tyynismaa H, 2010, HUM MOL GENET, V19, P3948, DOI 10.1093/hmg/ddq310
   Une K, 2011, EUR J NEUROL, V18, P1006, DOI 10.1111/j.1468-1331.2010.03194.x
   van Himbergen TM, 2012, ARCH NEUROL-CHICAGO, V69, P594, DOI 10.1001/archneurol.2011.670
   Vashist SK, 2017, TRENDS BIOTECHNOL, V35, P407, DOI 10.1016/j.tibtech.2016.12.006
   Vozarova B, 2001, OBES RES, V9, P414, DOI 10.1038/oby.2001.54
   Waki H, 2007, ANNU REV PATHOL-MECH, V2, P31, DOI 10.1146/annurev.pathol.2.010506.091859
   Wallenius V, 2002, NAT MED, V8, P75, DOI 10.1038/nm0102-75
   Wang DS, 2006, J BIOMED BIOTECHNOL, DOI 10.1155/JBB/2006/58406
   Wang HC, 2010, J CEREBR BLOOD F MET, V30, P493, DOI 10.1038/jcbfm.2009.247
   Wang JL, 1998, NATURE, V393, P684, DOI 10.1038/31474
   Wang JS, 2011, CLIN THER, V33, P1932, DOI 10.1016/j.clinthera.2011.10.014
   Wang QZ, 2018, MOL NEUROBIOL, V55, P4702, DOI 10.1007/s12035-017-0663-7
   Waragai M, 2016, J ALZHEIMERS DIS, V52, P1453, DOI 10.3233/JAD-151116
   Warren MW, 2012, J ALZHEIMERS DIS, V29, P151, DOI 10.3233/JAD-2012-111385
   Watanabe S, 2004, AM J NEPHROL, V24, P387, DOI 10.1159/000079706
   Weikert C, 2008, CIRCULATION, V118, P2555, DOI 10.1161/CIRCULATIONAHA.108.814418
   Wieckowska A, 2008, AM J GASTROENTEROL, V103, P1372, DOI 10.1111/j.1572-0241.2007.01774.x
   Wiesner G, 1999, J CLIN ENDOCR METAB, V84, P2270, DOI 10.1210/jc.84.7.2270
   Wilkinson M, 2007, NEUROENDOCRINOLOGY, V86, P191, DOI 10.1159/000108635
   Williams John W, 2010, Evid Rep Technol Assess (Full Rep), P1
   Wong VWS, 2006, CLIN GASTROENTEROL H, V4, P1154, DOI 10.1016/j.cgh.2006.06.011
   Wong VWS, 2010, GUT, V59, P969, DOI 10.1136/gut.2009.205088
   Woo YC, 2013, CLIN ENDOCRINOL, V78, P489, DOI 10.1111/cen.12095
   World Health Organization, 2012, WORLD HLTH STAT
   Wrann CD, 2013, CELL METAB, V18, P649, DOI 10.1016/j.cmet.2013.09.008
   Wu F, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0134662
   Wu SQ, 2016, SCI REP-UK, V6, DOI 10.1038/srep33386
   Wung BS, 2005, LIFE SCI, V78, P389, DOI 10.1016/j.lfs.2005.04.052
   Xin C, 2016, INT J OBESITY, V40, P443, DOI 10.1038/ijo.2015.199
   Xing Z, 1998, J CLIN INVEST, V101, P311, DOI 10.1172/JCI1368
   Xu AM, 2003, J CLIN INVEST, V112, P91, DOI 10.1172/JCI200317797
   Xu J, 2009, DIABETES, V58, P250, DOI 10.2337/db08-0392
   Xu Y, 2011, ATHEROSCLEROSIS, V216, P180, DOI 10.1016/j.atherosclerosis.2011.01.020
   Yamamoto Y, 2002, CLIN SCI, V103, P137, DOI 10.1042/CS20010336
   Yamauchi T, 2003, NATURE, V423, P762, DOI 10.1038/nature01705
   Yamauchi T, 2002, NAT MED, V8, P1288, DOI 10.1038/nm788
   Yamauchi T, 2001, NAT MED, V7, P941, DOI 10.1038/90984
   Yan Bing, 2014, PLoS One, V9, pe94235, DOI 10.1371/journal.pone.0094235
   Yanai H, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20051190
   Yang SJ, 2011, CLIN ENDOCRINOL, V75, P464, DOI 10.1111/j.1365-2265.2011.04078.x
   Yang Y, 2015, BBA-MOL BASIS DIS, V1852, P1887, DOI 10.1016/j.bbadis.2015.06.019
   Yokota T, 2000, BLOOD, V96, P1723, DOI 10.1182/blood.V96.5.1723
   Yokoyama H, 2007, METABOLISM, V56, P1458, DOI 10.1016/j.metabol.2007.06.010
   Yu X, 2008, P NATL ACAD SCI USA, V105, P14070, DOI 10.1073/pnas.0806993105
   Yu YH, 2015, PHARMACOL BIOCHEM BE, V133, P122, DOI 10.1016/j.pbb.2015.03.020
   Yusof MYM, 2013, DRUGS, V73, P341, DOI 10.1007/s40265-013-0018-2
   Zelber-Sagi S, 2012, J HEPATOL, V56, P1145, DOI 10.1016/j.jhep.2011.12.011
   Zelber-Sagi S, 2012, EUR J GASTROEN HEPAT, V24, P262, DOI 10.1097/MEG.0b013e32834f15dd
   Zhang D, 2011, J BIOL CHEM, V286, P44913, DOI 10.1074/jbc.M111.310052
   Zhang F, 2007, STROKE, V38, P2329, DOI 10.1161/STROKEAHA.107.482786
   Zhang M, 2014, EUR REV MED PHARMACO, V18, P1567
   Zhang X, 2008, DIABETES, V57, P1246, DOI 10.2337/db07-1476
   Zhang Y, 2014, DIABETES, V63, P514, DOI 10.2337/db13-1106
   ZHANG YY, 1994, NATURE, V372, P425, DOI 10.1038/372425a0
   Zhu SL, 2014, ACTA BIOCH BIOPH SIN, V46, P1041, DOI 10.1093/abbs/gmu097
   Zsuga J, 2016, BMC NEUROSCI, V17, DOI 10.1186/s12868-016-0302-7
   Zsuga J, 2016, MED HYPOTHESES, V90, P23, DOI 10.1016/j.mehy.2016.02.020
NR 406
TC 31
Z9 33
U1 0
U2 4
PU ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD
PI LONDON
PA 125 LONDON WALL, LONDON EC2Y 5AS, ENGLAND
SN 0065-2423
EI 2162-9471
BN 978-0-12-820801-4
J9 ADV CLIN CHEM
JI Advan. Clin. Chem.
PY 2020
VL 94
BP 261
EP 321
DI 10.1016/bs.acc.2019.07.012
PG 61
WC Medical Laboratory Technology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA BQ5XH
UT WOS:000609196500007
PM 31952573
DA 2025-06-11
ER

PT J
AU Addison, S
   Stas, S
   Hayden, MR
   Sowers, JR
AF Addison, Sonya
   Stas, Sameer
   Hayden, Melvin R.
   Sowers, James R.
TI Insulin resistance and blood pressure
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
ID TYPE-2 DIABETES-MELLITUS; C-REACTIVE PROTEIN; METABOLIC SYNDROME;
   HYPERTENSIVE PATIENTS; RECEPTOR BLOCKERS; OXIDATIVE STRESS;
   ANGIOTENSIN-II; ALDOSTERONE; METOPROLOL; TRIAL
AB Insulin resistance, cardiometabolic syndrome, and hypertension are common health problems with significant consequences for individuals and society. The pathogenesis of these disorders is complex and not fully understood. In this article we review the current knowledge about the effects of lifestyle modification and pharmacologic antihypertensive agents on insulin resistance and hypertension.
C1 [Addison, Sonya; Stas, Sameer; Hayden, Melvin R.; Sowers, James R.] Univ Missouri, Sch Med, Diabet & Cardiovasc Ctr, Harry S Truman VA Med Ctr, Columbia, MO 65212 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; University of Missouri
   System; University of Missouri Columbia
RP Sowers, JR (corresponding author), Univ Missouri, Sch Med, Diabet & Cardiovasc Ctr, Harry S Truman VA Med Ctr, D109 HSC Diabet Ctr,1 Hosp Dr, Columbia, MO 65212 USA.
EM sowersj@health.missouri.edu
CR [Anonymous], 2022, JAMA, V288, P2981, DOI [10.1001/jama, 10.1001/jama.288.23.2981, DOI 10.1001/JAMA.288.23.2981]
   Bakris GL, 2004, JAMA-J AM MED ASSOC, V292, P2227, DOI 10.1001/jama.292.18.2227
   Bank AJ, 2007, AM J HYPERTENS, V20, P777, DOI 10.1016/j.amjhyper.2007.01.019
   Bosch J, 2006, NEW ENGL J MED, V355, P1551
   Brouwer BG, 2007, AM HEART J, V154, P1146, DOI 10.1016/j.ahj.2007.07.031
   Brownlee M, 2005, DIABETES, V54, P1615, DOI 10.2337/diabetes.54.6.1615
   CARTER BL, 2000, J CLIN HYPERTENS, V7, P638
   Celik T, 2006, J HYPERTENS, V24, P591, DOI 10.1097/01.hjh.0000209993.26057.de
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   Clasen R, 2005, HYPERTENSION, V46, P137, DOI 10.1161/01.HYP.0000168046.19884.6a
   Cooper SA, 2007, AM J PHYSIOL-HEART C, V293, pH2009, DOI 10.1152/ajpheart.00522.2007
   Diamant Michaela, 2006, Curr Diab Rep, V6, P279, DOI 10.1007/s11892-006-0061-4
   El-Atat F, 2003, ENDOCRIN METAB CLIN, V32, P823, DOI 10.1016/S0889-8529(03)00070-7
   Fallo F, 2007, AM J HYPERTENS, V20, P855, DOI 10.1016/j.amjhyper.2007.03.012
   Fiebeler A, 2005, CIRCULATION, V111, P3087, DOI 10.1161/CIRCULATIONAHA.104.521625
   García-Puig J, 2006, AM J MED, V119, P318, DOI 10.1016/j.amjmed.2005.09.010
   Gillespie EL, 2005, DIABETES CARE, V28, P2261, DOI 10.2337/diacare.28.9.2261
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Ichikawa Y, 2007, INTERNAL MED, V46, P1331, DOI 10.2169/internalmedicine.46.7173
   Lakka TA, 2005, EUR HEART J, V26, P2018, DOI 10.1093/eurheartj/ehi394
   Lindholm LH, 2002, LANCET, V359, P1004, DOI 10.1016/S0140-6736(02)08090-X
   Lindholm LH, 2003, J HYPERTENS, V21, P1563, DOI 10.1097/00004872-200308000-00022
   Luft F, 2008, KIDNEY INT, V73, P679, DOI 10.1038/sj.ki.5002732
   Lutsey PL, 2008, CIRCULATION, V117, P754, DOI 10.1161/CIRCULATIONAHA.107.716159
   McKeown NM, 2004, DIABETES CARE, V27, P538, DOI 10.2337/diacare.27.2.538
   Nistala Ravi, 2006, J Cardiometab Syndr, V1, P47, DOI 10.1111/j.0197-3118.2006.05455.x
   Patel A, 2007, LANCET, V370, P829, DOI 10.1016/S0140-6736(07)61303-8
   Pitt B, 2003, NEW ENGL J MED, V348, P1309, DOI 10.1056/NEJMoa030207
   Pitt B, 1999, NEW ENGL J MED, V341, P709, DOI 10.1056/NEJM199909023411001
   Schutta Mark H, 2007, J Cardiometab Syndr, V2, P124, DOI 10.1111/j.1559-4564.2007.06368.x
   Shargorodsky Marina, 2007, J Cardiometab Syndr, V2, P16, DOI 10.1111/j.1559-4564.2007.888142.x
   Sowers JR, 2007, ENDOCRINOLOGIST, V17, P163, DOI 10.1097/01.ten.0000264954.79260.c2
   Sowers JR, 2004, AM J PHYSIOL-HEART C, V286, pH1597, DOI 10.1152/ajpheart.00026.2004
   Stas S, 2008, J CLIN HYPERTENS, V10, P94, DOI 10.1111/j.1751-7176.2008.08082.x
   Stas S, 2007, ENDOCRINOLOGY, V148, P3773, DOI 10.1210/en.2006-1691
   Stas S, 2006, CURR HYPERTENS REP, V8, P403, DOI 10.1007/s11906-006-0086-8
   Stevenson S, 2004, HIST PHOTOGR, V28, P226, DOI 10.1080/03087298.2004.10441320
   Takata Y, 2008, HYPERTENSION, V51, P534, DOI 10.1161/HYPERTENSIONAHA.107.103077
   Tan AS, 2004, ENDOCRINOLOGIST, V14, P368, DOI 10.1097/01.ten.0000146262.10013.e7
   Taylor EN, 2006, DIABETES CARE, V29, P1065, DOI 10.2337/dc05-2366
   Verdecchia P, 2004, HYPERTENSION, V43, P963, DOI 10.1161/01.HYP.0000125726.92964.ab
   Villamil A, 2007, J HYPERTENS, V25, P217, DOI 10.1097/HJH.0b013e3280103a6b
   Wright JT, 2008, ARCH INTERN MED, V168, P207, DOI 10.1001/archinternmed.2007.66
NR 43
TC 19
Z9 22
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD AUG
PY 2008
VL 10
IS 4
BP 319
EP 325
DI 10.1007/s11906-008-0059-1
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 329EC
UT WOS:000257848700013
PM 18625163
DA 2025-06-11
ER

PT J
AU Karimi, E
   Dehghan, P
   Azizi-Soleiman, F
   Mohamadizadeh, M
AF Karimi, Elham
   Dehghan, Parvin
   Azizi-Soleiman, Fatemeh
   Mohamadizadeh, Mehdi
TI Date seed (phoenix dactylifera) supplementation modulates oxidative DNA
   damage, lipid peroxidation, and cardiometabolic risk factors in type 2
   diabetes: A triple-blinded randomized placebo-controlled trial
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Date seed; Inflammation; Oxidative stress; Polyphenol; Functional food;
   Type 2 diabetes; Prebiotic
ID CHAIN FATTY-ACIDS; APO-B; ANTIOXIDANT; EXTRACT; COMPLICATIONS; STRESS
AB We examined if the supplementation of date seed powder (DSP) could improve inflammation, oxidative stress, and cardiometabolic status in diabetic patients. Forty three patients, aged 30-50 y, were randomized to receive either 5 g/d maltodextrin (i.e., placebo) or 5 g/d DSP (i.e. intervention) for eight weeks. Total cholesterol (TC), triglyceride (TG), low- and high-density lipoprotein cholesterol (LDL-c and HDL-c), the Castelli I Index (i.e., TC/ HDL-c ratio), and Atherogenic index [Log (TG/HDL-c)], lipopolysaccharide (LPS), high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-alpha), oxidative stress index (OSI), total oxidant status (TOS), malondialdehyde (MDA), 8-hydroxy-2 '-deoxyguanosine (8-OHdG), oxidized-LDL-c (ox-LDL-c), fasting plasma glucose (FPG), and glycated hemoglobin A1c (HbA1c) were measured at the baseline and end of the study. We used independent t-test and analysis of covariance (ANCOVA) for between-group comparisons at the baseline and the post-intervention phase, respectively. Between-group comparisons showed that supplementation with DSP significantly decreased HbA1c (-0.30%, p = 0.002), TC (-16.18 mg/dL, p = 0.001), TG (-21.27 mg/dL, p = 0.001), LDL-c (-13.41 mg/dL, p = 0.007), TC/HDL-c (-0.52, p = 0.001), LDL-c/HDL-c (-0.38, p = 0.003), Log (TG/HDL) (-0.06, p = 0.001), LPS (-3.67 EU/mL, p = 0.001), TNF-alpha (-3.69 ng/mL, p = 0.001), OSI (-5.01, p = 0.001), MDA (-0.25 nmol/mL, p = 0.010), 8-OHDG (-1.58 pg/mL, p = 0.002), and ox-LDL-c (-7.48 UL-1, p = 0.001). On the other hand, DSP supplementation significantly increased total antioxidant capacity (0.50 mmol/L, p = 0.001) compared to the placebo group. The two groups, however, were comparable regarding changes in FPG, HDL-c, VLDL-c, hs-CRP, and TOS. Overall, DSP seems to be an effective functional food for improving oxidative stress and cardiometabolic risk factors in diabetic patients. (Registration ID at https://www. irct.ir: IRCT20150205020965N10)
C1 [Karimi, Elham; Mohamadizadeh, Mehdi] Tabriz Univ Med Sci, Student Res Comm, Fac Nutr & Food Sci, Tabriz, Iran.
   [Dehghan, Parvin] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Dept Biochem & Diet Therapy, Tabriz, Iran.
   [Azizi-Soleiman, Fatemeh] Arak Univ Med Sci, Sch Hlth, Dept Nutr, Arak, Iran.
   [Dehghan, Parvin; Azizi-Soleiman, Fatemeh] Arak Univ Med Sci, Tabriz Univ Med Sci, Sch Hlth, Dept Nutr, Arak 3818146851, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science
RP Dehghan, P; Azizi-Soleiman, F (corresponding author), Arak Univ Med Sci, Tabriz Univ Med Sci, Sch Hlth, Dept Nutr, Arak 3818146851, Iran.
EM Dehghanp@tbzmed.ac.ir; azizi.s@arakmu.ac.ir;
   mohammadizadeh.m@tbzmed.ac.ir
RI Azizi-Soleiman, Fatemeh/W-1087-2019; dehghan, parvin/G-3885-2015;
   Karimi, Elham/AAW-7037-2020
FU Tabriz University of Medical Sciences [70183]
FX We express our gratitude to everyone who took part in the study. The
   Tabriz University of Medical Sciences provided funding for the research
   (grant number: 70183) .
CR Abdelaziz DHA, 2015, PHARM BIOL, V53, P792, DOI 10.3109/13880209.2014.942790
   Abuelo A, 2013, ANIMAL, V7, P1374, DOI 10.1017/S1751731113000396
   Adeneye AA, 2010, J ETHNOPHARMACOL, V130, P307, DOI 10.1016/j.jep.2010.05.009
   Ali S.E.-m., 2014, International Journal of Pharmaceutical Sciences And Research, V26, P62
   Bhaskar S, 2011, IMMUNOBIOLOGY, V216, P367, DOI 10.1016/j.imbio.2010.07.011
   Blatchford P., 2013, International Journal of Probiotics and Prebiotics, V8, P109
   Bouaziz MA, 2017, J TEXTURE STUD, V48, P143, DOI 10.1111/jtxs.12225
   Bouhlali E. D. T., 2017, Journal of the Saudi Society of Agricultural Sciences, V16, P350, DOI 10.1016/j.jssas.2015.11.002
   Canfora EE, 2015, NAT REV ENDOCRINOL, V11, P577, DOI 10.1038/nrendo.2015.128
   Chang CC, 2002, J FOOD DRUG ANAL, V10, P178
   Craig C., 2017, Journal of American College Health, V65, P492
   Dal Canto E, 2019, EUR J PREV CARDIOL, V26, P25, DOI 10.1177/2047487319878371
   Dehghan P, 2014, NUTRITION, V30, P418, DOI 10.1016/j.nut.2013.09.005
   Farhangi MA, 2020, EUR J NUTR, V59, P3009, DOI 10.1007/s00394-019-02140-z
   Felemban S., 2022, J. Pharm. Res. Int, V34, P23, DOI [10.9734/jpri/2022/v34i38A36214, DOI 10.9734/JPRI/2022/V34I38A36214]
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Ghafouri A, 2019, DIABETOL METAB SYNDR, V11, DOI 10.1186/s13098-019-0496-9
   Gharib M.a.a.-K., 2016, LIFE SCI J, V13, P10
   Godos J, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8060152
   Guilbert JJ, 2006, EDUC HEALTH, V19, P385, DOI 10.1080/13576280600937911
   Habib HM, 2022, NUTRIENTS, V14, DOI 10.3390/nu14173536
   Habib HM, 2011, J SCI FOOD AGR, V91, P1674, DOI 10.1002/jsfa.4368
   Hashemzadeh M., 2022, International Journal of Food Science & Technology
   Hattori Y, 1998, ATHEROSCLEROSIS, V138, P289, DOI 10.1016/S0021-9150(98)00034-3
   Huang W, 2017, EXP CLIN ENDOCR DIAB, V125, P98, DOI 10.1055/s-0042-121493
   Jubayer F, 2020, J HERB MED, V24, DOI 10.1016/j.hermed.2020.100409
   Khan TJ, 2018, BIOMED PHARMACOTHER, V107, P675, DOI 10.1016/j.biopha.2018.07.134
   Kim JM, 2010, AGE, V32, P197, DOI 10.1007/s11357-009-9124-1
   Kim Y, 2016, NUTRIENTS, V8, DOI 10.3390/nu8010017
   Ma J, 2020, ANIM NUTR, V6, P404, DOI 10.1016/j.aninu.2020.08.002
   Moorthy M, 2021, FOODS, V10, DOI 10.3390/foods10020299
   Moslemi E, 2023, EUR J NUTR, V62, P2001, DOI 10.1007/s00394-023-03125-9
   Moslemi E, 2023, BRIT J NUTR, V129, P1151, DOI 10.1017/S0007114522002124
   Musazadeh V., 2022, Journal of Functional Foods, V99
   Musazadeh V, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1121541
   Na HK, 2008, FOOD CHEM TOXICOL, V46, P1271, DOI 10.1016/j.fct.2007.10.006
   Nguyen TTU, 2021, J CLIN MED, V10, DOI 10.3390/jcm10194456
   Oguntibeju Oluwafemi Omoniyi, 2019, Int J Physiol Pathophysiol Pharmacol, V11, P45
   Pan HB, 2016, MOLECULES, V21, DOI 10.3390/molecules21121659
   Petersmann A, 2019, EXP CLIN ENDOCR DIAB, V127, pS1, DOI 10.1055/a-1018-9078
   Platat C, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102489
   Pourrajab B, 2022, CRIT REV FOOD SCI, V62, P490, DOI 10.1080/10408398.2020.1821166
   Rahmawati E., 2016, International Journal of Research in Medical Sciences, V4, P1893
   Raimundo AF, 2020, EUR J NUTR, V59, P1329, DOI 10.1007/s00394-020-02189-1
   Rajendiran D., 2018, ASIAN J PHARM CLIN R, V11, P48, DOI [10.22159/ajpcr.2018.v11i2.23241, DOI 10.22159/AJPCR.2018.V11I2.23241]
   Ranjit PM., 2015, Asian Journal of Medical Sciences, V6, P25, DOI 10.3126/ajms.v6i6.12209
   Remigante A, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23147781
   Teixeira KTR, 2022, CLIN NUTR ESPEN, V47, P63, DOI 10.1016/j.clnesp.2021.11.012
   Ruan YT, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0132121
   Saleh-Ghadimi S, 2022, J SCI FOOD AGR, V102, P5229, DOI 10.1002/jsfa.11876
   Saryono, 2020, SAUDI PHARM J, V28, P1014, DOI 10.1016/j.jsps.2020.06.024
   Saryono S., 2017, PAK J NUTR, V16, P477, DOI DOI 10.3923/PJN.2017.477.481
   Saryono Saryono, 2018, Toxicology and Environmental Health Sciences, V10, P139, DOI 10.1007/s13530-018-0357-1
   Shama S, 2020, DIGEST DIS SCI, V65, P906, DOI 10.1007/s10620-020-06117-5
   Shidfar F, 2012, IRAN J PHARM RES, V11, P643
   SINGLETON V. L., 1965, AMER J ENOL VITICULT, V16, P144
   Sun H, 2022, DIABETES RES CLIN PR, V183, DOI 10.1016/j.diabres.2021.109119
   Tatsch E, 2015, MUTAT RES-FUND MOL M, V782, P17, DOI 10.1016/j.mrfmmm.2015.10.003
   Vahedi-Mazdabadi Y, 2023, PHYTOTHER RES, V37, P5541, DOI 10.1002/ptr.7998
   Williams S., 1984, Official Methods of Analysis
   Zadeh MM, 2023, BMJ OPEN, V13, DOI 10.1136/bmjopen-2022-066013
   Zarezadeh M, 2022, PHARMACOL RES, V183, DOI 10.1016/j.phrs.2022.106397
   Zarezadeh M, 2022, CRIT REV FOOD SCI, V63, P145, DOI 10.1080/10408398.2021.2004578
   Zobia Mushtaq Zobia Mushtaq, 2017, Khyber Medical University Journal, V9, P135
NR 64
TC 1
Z9 1
U1 1
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JUN
PY 2024
VL 117
AR 106226
DI 10.1016/j.jff.2024.106226
EA MAY 2024
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA TQ0A4
UT WOS:001242595200001
OA gold
DA 2025-06-11
ER

PT J
AU Thomas, MS
   Huang, L
   Garcia, C
   Sakaki, JR
   Blesso, CN
   Chun, OK
   Fernandez, ML
AF Thomas, Minu S.
   Huang, Lindsey
   Garcia, Chelsea
   Sakaki, Junichi R.
   Blesso, Christopher N.
   Chun, Ock K.
   Fernandez, Maria Luz
TI The Effects of Eggs in a Plant-Based Diet on Oxidative Stress and
   Inflammation in Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; eggs; plant-based diet; spinach; inflammation;
   oxidative stress
ID TOTAL ANTIOXIDANT CAPACITY; RISK; ASSOCIATION; MARKERS; VEGETARIANS;
   PROFILES; DISEASE; PROTEIN
AB We recently reported that the inclusion of whole eggs in plant-based diets (PBD) increased plasma choline, lutein, and zeaxanthin in individuals with metabolic syndrome (MetS). The objective of the current study was to evaluate whether this dietary pattern would protect against oxidative stress and low-grade inflammation, two common characteristics of MetS. We recruited 24 men and women with MetS, who, after following a PBD for 2 weeks (baseline), were randomly allocated to consume either two whole eggs with 70 g of spinach/day (EGG) or the equivalent amount of egg substitute with spinach (SUB) as breakfast for 4 weeks. After a 3-week washout, they were allocated to the alternate breakfast. We measured biomarkers of oxidation and inflammation at baseline and at the end of each intervention. Tumor necrosis factor-alpha, interleukin-6, monocyte protein attractant-1, liver enzymes, and C-reactive protein, as well as total antioxidant capacity, paraoxonase-1 (PON-1) activity, and other biomarkers of oxidation were not different at the end of EGG or SUB or when compared to baseline. However, plasma malondialdehyde (MDA) concentrations were lower (p < 0.05) during the EGG and baseline compared to SUB. In addition, the increases in dietary lutein and zeaxanthin previously observed had a strong positive correlation with PON-1 activity (r = 0.522, p < 0.01) only during the EGG period, whereas plasma zeaxanthin was negatively correlated with MDA (r = -0.437, p < 0.01). The number of participants with MetS was reduced from 24 during screening to 21, 13, and 17 during the BL, EGG, and SUB periods, respectively, indicating that eggs were more effective in reversing the characteristics of MetS. These data suggest that adding eggs to a PBD does not detrimentally affect inflammation or oxidative stress; on the contrary, eggs seem to provide additional protection against the biomarkers that define MetS.
C1 [Thomas, Minu S.; Huang, Lindsey; Garcia, Chelsea; Sakaki, Junichi R.; Blesso, Christopher N.; Chun, Ock K.; Fernandez, Maria Luz] Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
C3 University of Connecticut
RP Fernandez, ML (corresponding author), Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
EM minu.thomas@uconn.edu; lindsey.huang@uconn.edu;
   chelsea.garcia@uconn.edu; junichi.sakaki@uconn.edu;
   christopher.blesso@uconn.edu; ock.chun@uconn.edu;
   maria-luz.fernandez@uconn.edu
RI Blesso, Christopher/N-9495-2014; Thomas, Minu Sara/GOH-1463-2022
OI Blesso, Christopher/0000-0002-4434-4839; Garcia,
   Chelsea/0000-0002-7681-695X; Thomas, Minu Sara/0000-0002-1639-3086;
   Fernandez, Maria-Luz/0000-0002-1835-0792; Chun, Ock/0000-0002-7391-2380
FU Egg Nutrition Center, Chicago, IL, USA
FX This study was funded by the Egg Nutrition Center, Chicago, IL, USA.
CR Al-Yousef H. M., 2018, Current Topics in Biochemical Research, V19, P25
   Bakaloudi DR, 2021, CLIN NUTR, V40, P3503, DOI 10.1016/j.clnu.2020.11.035
   Bakhtiari A, 2017, BIOMED REP, V7, P331, DOI 10.3892/br.2017.964
   Ballout Rami A, 2020, J Lab Precis Med, V5, DOI 10.21037/jlpm.2020.03.03
   Blesso CN, 2013, J CLIN LIPIDOL, V7, P463, DOI 10.1016/j.jacl.2013.03.008
   Blesso CN, 2013, METABOLISM, V62, P400, DOI 10.1016/j.metabol.2012.08.014
   Clarys P, 2014, NUTRIENTS, V6, P1318, DOI 10.3390/nu6031318
   Connelly MA, 2017, J TRANSL MED, V15, DOI 10.1186/s12967-017-1321-6
   Craddock JC, 2019, ADV NUTR, V10, P433, DOI 10.1093/advances/nmy103
   da Rosa EM, 2008, ARQ BRAS CARDIOL, V91, P263
   Dekker JM, 2005, CIRCULATION, V112, P666, DOI 10.1161/CIRCULATIONAHA.104.516948
   DiBella M., Current Developments in Nutrition, V2020, P389, DOI DOI 10.1093/CDN/NZAA045_022
   DiBella M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12103120
   Dinu M, 2017, CRIT REV FOOD SCI, V57, P3640, DOI 10.1080/10408398.2016.1138447
   Eichelmann F, 2016, OBES REV, V17, P1067, DOI 10.1111/obr.12439
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Fernandez ML, 2018, CURR PHARM DESIGN, V24, P1905, DOI 10.2174/1381612824666180316114832
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Haghighatdoost F, 2017, PUBLIC HEALTH NUTR, V20, P2713, DOI [10.1017/S1368980017001768, 10.1017/s1368980017001768]
   Hildrum B, 2007, BMC PUBLIC HEALTH, V7, DOI 10.1186/1471-2458-7-220
   Ho E, 2013, REDOX BIOL, V1, P483, DOI 10.1016/j.redox.2013.07.006
   Hutcheson R, 2012, EXP DIABETES RES, DOI 10.1155/2012/271028
   Jiang LL, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.637782
   Jiang S, 2021, FOODS, V10, DOI 10.3390/foods10081854
   Khersonsky O, 2005, BIOCHEMISTRY-US, V44, P6371, DOI 10.1021/bi047440d
   Kim MK, 2012, NUTR RES PRACT, V6, P155, DOI 10.4162/nrp.2012.6.2.155
   Kotani K, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/481437
   Lee SG, 2017, J MICROBIOL BIOTECHN, V27, P388, DOI 10.4014/jmb.1604.04053
   Lopez-Legarrea P, 2014, NUTRITION, V30, P424, DOI 10.1016/j.nut.2013.09.009
   Quetglas-Llabrés MM, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11050901
   Menzel J, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-58875-x
   Millar CL, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201800404
   Millar CL, 2018, METAB SYNDR RELAT D, V16, P464, DOI 10.1089/met.2018.0052
   Mohammadi M, 2017, REP BIOCHEM MOL BIOL, V6, P74
   Moreto F, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/505368
   Nettleton JA, 2006, AM J CLIN NUTR, V83, P1369, DOI 10.1093/ajcn/83.6.1369
   Nimalaratne C, 2015, NUTRIENTS, V7, P8274, DOI 10.3390/nu7105394
   Rosenson RS, 2016, NAT REV CARDIOL, V13, P48, DOI 10.1038/nrcardio.2015.124
   Satija A, 2017, J AM COLL CARDIOL, V70, P411, DOI 10.1016/j.jacc.2017.05.047
   Thomas MS, 2022, METAB SYNDR RELAT D, V20, P429, DOI 10.1089/met.2021.0131
   Thomas MS, 2022, NUTRIENTS, V14, DOI 10.3390/nu14102138
   Thomas MS, 2022, NUTRIENTS, V14, DOI 10.3390/nu14061179
   Thomas MS, 2021, CURR ATHEROSCLER REP, V23, DOI 10.1007/s11883-021-00910-x
   Tomova A, 2019, FRONT NUTR, V6, DOI 10.3389/fnut.2019.00047
   Wang Y, 2012, J ACAD NUTR DIET, V112, P1626, DOI 10.1016/j.jand.2012.06.007
   Xue QP, 2022, NUTR METAB, V19, DOI 10.1186/s12986-021-00632-6
NR 46
TC 11
Z9 11
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2022
VL 14
IS 12
AR 2548
DI 10.3390/nu14122548
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 2K2JU
UT WOS:000816169800001
PM 35745278
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ravaut, G
   Légiot, A
   Bergeron, KF
   Mounier, C
AF Ravaut, Gaetan
   Legiot, Alexandre
   Bergeron, Karl-F.
   Mounier, Catherine
TI Monounsaturated Fatty Acids in Obesity-Related Inflammation
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE monounsaturated fatty acids (MUFA); stearoyl-CoA desaturase-1 (SCD1);
   chronic inflammation; saturated fatty acid (SFA); metabolic syndrome
ID ENDOPLASMIC-RETICULUM STRESS; NF-KAPPA-B; DEFICIENCY PROTECTS MICE; COA
   DESATURASE-1 GENE; C-REACTIVE PROTEIN; VIRGIN OLIVE OIL;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; MEDITERRANEAN DIET;
   ADIPOSE-TISSUE
AB Obesity is an important aspect of the metabolic syndrome and is often associated with chronic inflammation. In this context, inflammation of organs participating in energy homeostasis (such as liver, adipose tissue, muscle and pancreas) leads to the recruitment and activation of macrophages, which secrete pro-inflammatory cytokines. Interleukin-1 beta secretion, sustained C-reactive protein plasma levels and activation of the NLRP3 inflammasome characterize this inflammation. The Stearoyl-CoA desaturase-1 (SCD1) enzyme is a central regulator of lipid metabolism and fat storage. This enzyme catalyzes the generation of monounsaturated fatty acids (MUFAs)-major components of triglycerides stored in lipid droplets-from saturated fatty acid (SFA) substrates. In this review, we describe the molecular effects of specific classes of fatty acids (saturated and unsaturated) to better understand the impact of different diets (Western versus Mediterranean) on inflammation in a metabolic context. Given the beneficial effects of a MUFA-rich Mediterranean diet, we also present the most recent data on the role of SCD1 activity in the modulation of SFA-induced chronic inflammation.
C1 [Ravaut, Gaetan; Legiot, Alexandre; Bergeron, Karl-F.; Mounier, Catherine] Univ Quebec Montreal UQAM, Dept Biol Sci, Mol Metab Lipids Lab, CERMO FC Res Ctr, Montreal, PQ H3C 3P8, Canada.
C3 University of Quebec; University of Quebec Montreal
RP Mounier, C (corresponding author), Univ Quebec Montreal UQAM, Dept Biol Sci, Mol Metab Lipids Lab, CERMO FC Res Ctr, Montreal, PQ H3C 3P8, Canada.
EM ravaut.gaetan@courrier.uqam.ca; legiot.alexandre@courrier.uqam.ca;
   bergeron.karl-frederik@uqam.ca; mounier.catherine@uqam.ca
RI Mounier, Catherine/D-3690-2011
OI Ravaut, Gaetan/0000-0003-3309-3154; Bergeron,
   Karl-F./0000-0002-7215-9104
FU NSREC grant
FX G.R. was supported by the foundation Lueur d'espoir pour Ayden and A.L.
   by a NSREC grant.
CR Acosta-Montaño P, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8080884
   Ahechu P, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.02918
   Ameer F, 2014, METABOLISM, V63, P895, DOI 10.1016/j.metabol.2014.04.003
   Antonopoulos AS, 2017, CARDIOVASC RES, V113, P1074, DOI 10.1093/cvr/cvx106
   Antunes MM, 2020, BRAZ J MED BIOL RES, V53, DOI [10.1590/1414-431X20199039, 10.1590/1414-431x20199039]
   Anty R, 2019, PRESSE MED, V48, P1468, DOI 10.1016/j.lpm.2019.09.051
   Arroyo-Johnson C, 2016, GASTROENTEROL CLIN N, V45, P571, DOI 10.1016/j.gtc.2016.07.012
   Ason B, 2011, LIPIDS, V46, P991, DOI 10.1007/s11745-011-3596-3
   Berg AH, 2005, CIRC RES, V96, P939, DOI 10.1161/01.RES.0000163635.62927.34
   Bonen A, 2000, J BIOL CHEM, V275, P14501, DOI 10.1074/jbc.275.19.14501
   Bosquet A, 2018, BBA-MOL CELL BIOL L, V1863, P604, DOI 10.1016/j.bbalip.2018.03.004
   Brown JM, 2008, CIRCULATION, V118, P1467, DOI 10.1161/CIRCULATIONAHA.108.793182
   Calder PC, 2011, BRIT J NUTR, V106, pS1, DOI 10.1017/S0007114511005460
   Cândido FG, 2018, INT J FOOD SCI NUTR, V69, P125, DOI 10.1080/09637486.2017.1343286
   Carbone F, 2012, BIOCHIMIE, V94, P2082, DOI 10.1016/j.biochi.2012.05.018
   Casas R, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19123988
   Casas R, 2018, ENDOCR METAB IMMUNE, V18, P23, DOI 10.2174/1871530317666171114115632
   Castellano-Castillo D, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0215083
   Cedernaes J, 2013, LIPIDS HEALTH DIS, V12, DOI 10.1186/1476-511X-12-2
   Cesari F, 2018, NUTR METAB CARDIOVAS, V28, P84, DOI 10.1016/j.numecd.2017.09.003
   Cevenini E, 2013, CURR OPIN CLIN NUTR, V16, P14, DOI 10.1097/MCO.0b013e32835ada13
   Chambers JC, 2001, CIRCULATION, V104, P145, DOI 10.1161/01.CIR.104.2.145
   Chan KL, 2015, J BIOL CHEM, V290, P16979, DOI 10.1074/jbc.M115.646992
   Chen C, 2008, CELL METAB, V7, P135, DOI 10.1016/j.cmet.2007.12.003
   Chen HE, 2016, IUBMB LIFE, V68, P145, DOI 10.1002/iub.1470
   Chen XM, 2018, LIFE SCI, V203, P291, DOI 10.1016/j.lfs.2018.04.022
   Chinetti-Gbaguidi G, 2011, CURR OPIN LIPIDOL, V22, P365, DOI 10.1097/MOL.0b013e32834a77b4
   Çimen I, 2016, SCI TRANSL MED, V8, DOI 10.1126/scitranslmed.aaf9087
   Cnop M, 2008, BIOCHEM SOC T, V36, P348, DOI 10.1042/BST0360348
   Costantini L, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18122645
   da Silva-Santi LG, 2018, NUTRIENTS, V10, DOI 10.3390/nu10091277
   da Silva-Santi LG, 2016, NUTRIENTS, V8, DOI 10.3390/nu8110682
   Dalla Valle A, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00726
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   Dandona P, 2004, TRENDS IMMUNOL, V25, P4, DOI 10.1016/j.it.2003.10.013
   De Filippis Francesca, 2016, Gut, V65, P1812, DOI 10.1136/gutjnl-2015-309957
   De Pergola G, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111700
   de Souza CO, 2017, J CELL PHYSIOL, V232, P2168, DOI 10.1002/jcp.25715
   de Souza CO, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201800322
   Décarie-Spain L, 2018, MOL METAB, V10, P1, DOI 10.1016/j.molmet.2018.01.018
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Diakogiannaki E, 2008, J ENDOCRINOL, V197, P553, DOI 10.1677/JOE-08-0041
   Dietze-Schroeder D, 2005, DIABETES, V54, P2003, DOI 10.2337/diabetes.54.7.2003
   Donath MY, 2011, NAT REV IMMUNOL, V11, P98, DOI 10.1038/nri2925
   Ducheix S, 2018, GASTROENTEROLOGY, V155, P1524, DOI 10.1053/j.gastro.2018.07.032
   Dumas SN, 2019, BIOCHEM BIOPH RES CO, V508, P87, DOI 10.1016/j.bbrc.2018.11.083
   Eisele PS, 2013, J BIOL CHEM, V288, P2246, DOI 10.1074/jbc.M112.375253
   Engin AB, 2017, ADV EXP MED BIOL, V960, P197, DOI 10.1007/978-3-319-48382-5_8
   Ertunc ME, 2016, J LIPID RES, V57, P2099, DOI 10.1194/jlr.R066514
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   Esposito K, 2017, ENDOCRINE, V56, P27, DOI 10.1007/s12020-016-1018-2
   Fang H, 2018, COMPR PHYSIOL, V8, P1031, DOI 10.1002/cphy.c170046
   Feillet-Coudray C, 2019, LIPIDS, V54, P81, DOI 10.1002/lipd.12128
   Finucane OM, 2015, DIABETES, V64, P2116, DOI 10.2337/db14-1098
   Flowers MT, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019734
   Gabay C, 1999, NEW ENGL J MED, V340, P448, DOI 10.1056/NEJM199902113400607
   Galland L, 2010, NUTR CLIN PRACT, V25, P634, DOI 10.1177/0884533610385703
   Gehrmann W, 2015, CELL PHYSIOL BIOCHEM, V36, P852, DOI 10.1159/000430261
   Goodpaster BH, 2005, ARCH INTERN MED, V165, P777, DOI 10.1001/archinte.165.7.777
   Granados N, 2011, BRIT J NUTR, V105, P1226, DOI 10.1017/S0007114510004885
   Grandl G, 2018, SEMIN IMMUNOPATHOL, V40, P215, DOI 10.1007/s00281-017-0666-5
   GREENBERGER NJ, 1969, NEW ENGL J MED, V280, P1045, DOI 10.1056/NEJM196905082801906
   Guo W, 2007, AM J PHYSIOL-ENDOC M, V293, pE576, DOI 10.1152/ajpendo.00523.2006
   Hirasawa A, 2005, NAT MED, V11, P90, DOI 10.1038/nm1168
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Hu JM, 2018, CRIT REV FOOD SCI, V58, P1243, DOI 10.1080/10408398.2016.1245650
   Hu W, 2011, J BIOL CHEM, V286, P16596, DOI 10.1074/jbc.M110.186916
   Huang SR, 2012, J LIPID RES, V53, P2002, DOI 10.1194/jlr.D029546
   Ichimura A, 2012, NATURE, V483, P350, DOI 10.1038/nature10798
   Igal RA, 2021, BBA-MOL CELL BIOL L, V1866, DOI 10.1016/j.bbalip.2020.158840
   Iwaki M, 2003, DIABETES, V52, P1655, DOI 10.2337/diabetes.52.7.1655
   Ji J, 2017, J DERMATOL, V44, P1097, DOI 10.1111/1346-8138.13897
   Jimenez-Gomez Yolanda, 2009, Atherosclerosis, V204, pe70, DOI 10.1016/j.atherosclerosis.2008.09.011
   Johnson L, 2008, AM J CLIN NUTR, V87, P846, DOI 10.1093/ajcn/87.4.846
   KAESTNER KH, 1989, J BIOL CHEM, V264, P14755
   Kanda H, 2006, J CLIN INVEST, V116, P1494, DOI 10.1172/JCI26498
   Kang K, 2008, CELL METAB, V7, P485, DOI 10.1016/j.cmet.2008.04.002
   Karczewski J, 2018, EUR CYTOKINE NETW, V29, P83, DOI 10.1684/ecn.2018.0415
   Kauppinen A, 2013, CELL SIGNAL, V25, P1939, DOI 10.1016/j.cellsig.2013.06.007
   Kennedy A, 2009, J NUTR, V139, P1, DOI 10.3945/jn.108.098269
   Kirwan AM, 2017, BIOCHEM SOC T, V45, P979, DOI 10.1042/BST20160465
   Konstantinidou V, 2013, MOL NUTR FOOD RES, V57, P772, DOI 10.1002/mnfr.201200613
   Konstantinidou V, 2010, FASEB J, V24, P2546, DOI 10.1096/fj.09-148452
   Kwon B, 2015, BIOCHIMIE, V118, P141, DOI 10.1016/j.biochi.2015.09.006
   Lee BC, 2014, BBA-MOL BASIS DIS, V1842, P446, DOI 10.1016/j.bbadis.2013.05.017
   Lee JJ, 2015, AM J CLIN NUTR, V101, P34, DOI 10.3945/ajcn.114.092262
   Lee JY, 2003, J BIOL CHEM, V278, P37041, DOI 10.1074/jbc.M305213200
   Lee SH, 2004, J LIPID RES, V45, P1674, DOI 10.1194/jlr.M400039-JLR200
   Li C, 2020, FISH SHELLFISH IMMUN, V100, P358, DOI 10.1016/j.fsi.2020.03.014
   Liu G, 2019, FASEB J, V33, P10089, DOI 10.1096/fj.201802619RR
   Liu XL, 2017, WORLD J GASTROENTERO, V23, P8140, DOI 10.3748/wjg.v23.i46.8140
   Liu XQ, 2010, ARTERIOSCL THROM VAS, V30, P31, DOI 10.1161/ATVBAHA.109.195636
   Lo Verme J, 2005, MOL PHARMACOL, V67, P15, DOI 10.1124/mol.104.006353
   Lounis MA, 2017, AM J PHYSIOL-ENDOC M, V313, pE710, DOI 10.1152/ajpendo.00151.2017
   Lounis MA, 2016, BBA-MOL CELL BIOL L, V1861, P1662, DOI 10.1016/j.bbalip.2016.07.012
   Lounis MA, 2017, LIPIDS, V52, P129, DOI 10.1007/s11745-016-4210-5
   Lovren F, 2010, AM J PHYSIOL-HEART C, V299, pH656, DOI 10.1152/ajpheart.00115.2010
   Lu Y, 2004, MOL GENET GENOMICS, V272, P129, DOI 10.1007/s00438-004-1043-3
   Lundman P, 2007, NUTR METAB CARDIOVAS, V17, P195, DOI 10.1016/j.numecd.2005.11.009
   Ly LD, 2017, EXP MOL MED, V49, DOI 10.1038/emm.2016.157
   Lyons CL, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19103092
   MacDonald MLE, 2009, ARTERIOSCL THROM VAS, V29, P341, DOI 10.1161/ATVBAHA.108.181099
   Malodobra-Mazur M, 2014, INT J BIOCHEM CELL B, V55, P40, DOI 10.1016/j.biocel.2014.08.005
   Man WC, 2006, J LIPID RES, V47, P1928, DOI 10.1194/jlr.M600172-JLR200
   Martín-Peláez S, 2017, EUR J NUTR, V56, P119, DOI 10.1007/s00394-015-1063-2
   Mastrocola R, 2018, CURR MED CHEM, V25, P1294, DOI 10.2174/0929867324666170407123522
   Matsuzaka T, 2020, HEPATOLOGY, V71, P1609, DOI 10.1002/hep.30953
   Mauvoisin D, 2011, BIOCHIMIE, V93, P78, DOI 10.1016/j.biochi.2010.08.001
   Mauvoisin D, 2007, J CELL COMMUN SIGNAL, V1, P113, DOI 10.1007/s12079-007-0011-1
   Mika A, 2018, POL ARCH INTERN MED, V128, P755, DOI 10.20452/pamw.4376
   Miyazaki M, 2006, J LIPID RES, V47, P700, DOI 10.1194/jlr.C500025-JLR200
   Miyazaki M, 2003, J BIOL CHEM, V278, P33904, DOI 10.1074/jbc.M304724200
   Miyazaki M, 2002, J LIPID RES, V43, P2146, DOI 10.1194/jlr.M200271-JLR200
   Miyazaki M, 2001, J NUTR, V131, P2260, DOI 10.1093/jn/131.9.2260
   Miyazaki M, 2000, J BIOL CHEM, V275, P30132, DOI 10.1074/jbc.M005488200
   Miyazaki M, 2007, CELL METAB, V6, P484, DOI 10.1016/j.cmet.2007.10.014
   Miyazaki M, 2009, BIOCHEM BIOPH RES CO, V380, P818, DOI 10.1016/j.bbrc.2009.01.183
   Montserrat-de la Paz S, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201900425
   Montserrat-de la Paz S, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600824
   Mukherjee P, 2018, J LIPID RES, V59, P1818, DOI 10.1194/jlr.M083527
   Murdoch JR, 2010, MUTAT RES-FUND MOL M, V690, P24, DOI 10.1016/j.mrfmmm.2009.09.005
   Murray PJ, 2017, ANNU REV PHYSIOL, V79, P541, DOI 10.1146/annurev-physiol-022516-034339
   Nagao K, 2019, CHEM PHARM BULL, V67, P327, DOI 10.1248/cpb.c18-01001
   Najt CP, 2020, MOL CELL, V77, P810, DOI 10.1016/j.molcel.2019.12.003
   Namgaladze D, 2016, BBA-MOL CELL BIOL L, V1861, P1796, DOI 10.1016/j.bbalip.2016.09.002
   Nemecz M, 2019, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01554
   Nieuwdorp M, 2005, CURR OPIN PHARMACOL, V5, P155, DOI 10.1016/j.coph.2004.10.003
   NTAMBI JM, 1995, PROSTAG LEUKOTR ESS, V52, P117, DOI 10.1016/0952-3278(95)90009-8
   Ntambi JM, 2002, P NATL ACAD SCI USA, V99, P11482, DOI 10.1073/pnas.132384699
   Oran A, 1997, BRIT J DERMATOL, V136, P519, DOI 10.1046/j.1365-2133.1997.6081584.x
   Ortega-Prieto P, 2019, FRONT GENET, V10, DOI 10.3389/fgene.2019.00472
   Oshima M, 2020, DIABETOLOGIA, V63, P395, DOI 10.1007/s00125-019-05046-x
   Ouimet M, 2019, CIRC RES, V124, P1505, DOI 10.1161/CIRCRESAHA.119.312617
   Paniagua JA, 2007, DIABETES CARE, V30, P1717, DOI 10.2337/dc06-2220
   Patil R, 2019, J BIOL CHEM, V294, P3720, DOI 10.1074/jbc.RA118.006848
   Peter A, 2009, DIABETES, V58, P1757, DOI 10.2337/db09-0188
   Quiles JL, 2010, MECH AGEING DEV, V131, P38, DOI 10.1016/j.mad.2009.11.004
   Raatz SK, 2018, AM J CLIN NUTR, V108, P594, DOI 10.1093/ajcn/nqy127
   Ralston JC, 2020, BRIT J NUTR, V124, P247, DOI 10.1017/S0007114520000859
   Ralston JC, 2016, J NUTR BIOCHEM, V27, P241, DOI 10.1016/j.jnutbio.2015.09.011
   Rocha DM, 2017, SAO PAULO MED J, V135, P157, DOI 10.1590/1516-3180.2016.008607072016
   Rodier F, 2011, J CELL BIOL, V192, P547, DOI 10.1083/jcb.201009094
   Rosen ED, 2001, J BIOL CHEM, V276, P37731, DOI 10.1074/jbc.R100034200
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Saltiel AR, 2017, J CLIN INVEST, V127, P1, DOI [10.1172/JCI92035, 10.1172/jci92035]
   Sampath H, 2009, J BIOL CHEM, V284, P19961, DOI 10.1074/jbc.M109.014225
   Schneider MR, 2015, EXP DERMATOL, V24, P340, DOI 10.1111/exd.12664
   Schwingshackl L, 2015, NUTRIENTS, V7, P7651, DOI 10.3390/nu7095356
   Serhan CN, 2007, ANNU REV IMMUNOL, V25, P101, DOI 10.1146/annurev.immunol.25.022106.141647
   Shahidi F, 2018, ANNU REV FOOD SCI T, V9, P345, DOI 10.1146/annurev-food-111317-095850
   Sherling DH, 2017, J CARDIOVASC PHARM T, V22, P365, DOI 10.1177/1074248416686187
   Shi X, 2013, J LIPID RES, V54, P2504, DOI 10.1194/jlr.M039669
   Shively CA, 2019, OBESITY, V27, P777, DOI 10.1002/oby.22436
   Sieber J, 2010, AM J PHYSIOL-RENAL, V299, pF821, DOI 10.1152/ajprenal.00196.2010
   Softic S, 2016, DIGEST DIS SCI, V61, P1282, DOI 10.1007/s10620-016-4054-0
   Stryjecki C, 2012, MOL GENET METAB, V105, P421, DOI 10.1016/j.ymgme.2011.12.003
   Summers SA, 2006, PROG LIPID RES, V45, P42, DOI 10.1016/j.plipres.2005.11.002
   Sun SC, 2017, NAT REV IMMUNOL, V17, P545, DOI 10.1038/nri.2017.52
   Swanson KV, 2019, NAT REV IMMUNOL, V19, P477, DOI 10.1038/s41577-019-0165-0
   Tamer F, 2020, FOOD CHEM TOXICOL, V135, DOI 10.1016/j.fct.2019.110914
   Tang Y, 2017, CLIN EXP PHARMACOL P, V44, P9, DOI 10.1111/1440-1681.12758
   Tchernof A, 2013, PHYSIOL REV, V93, P359, DOI 10.1152/physrev.00033.2011
   Thiam AR, 2017, J CELL SCI, V130, P315, DOI 10.1242/jcs.192021
   Toscano R, 2020, J NUTR BIOCHEM, V75, DOI 10.1016/j.jnutbio.2019.108248
   Trajkovska KT, 2017, ANATOL J CARDIOL, V18, P149, DOI 10.14744/AnatolJCardiol.2017.7608
   Tran DQ, 2016, MOL CELL ENDOCRINOL, V438, P18, DOI 10.1016/j.mce.2016.05.015
   TRICHOPOULOU A, 1993, EUR J CLIN NUTR, V47, pS76
   Tu TH, 2019, BIOCHEM BIOPH RES CO, V513, P201, DOI 10.1016/j.bbrc.2019.03.047
   Tuttolomondo A, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20194716
   Unger RH, 2002, ANNU REV MED, V53, P319, DOI 10.1146/annurev.med.53.082901.104057
   Vaittinen M, 2017, OBESITY, V25, P545, DOI 10.1002/oby.21753
   van Herpen NA, 2008, PHYSIOL BEHAV, V94, P231, DOI 10.1016/j.physbeh.2007.11.049
   Vandanmagsar B, 2011, NAT MED, V17, P179, DOI 10.1038/nm.2279
   Walther TC, 2017, ANNU REV CELL DEV BI, V33, P491, DOI 10.1146/annurev-cellbio-100616-060608
   Wang ZN, 2018, PROTEIN CELL, V9, P416, DOI 10.1007/s13238-018-0549-0
   Waters KM, 1996, LIPIDS, V31, pS33, DOI 10.1007/BF02637047
   Weiss R, 2004, NEW ENGL J MED, V350, P2362, DOI 10.1056/NEJMoa031049
   Weiss-Hersh K, 2020, EUR J NUTR, V59, P2759, DOI 10.1007/s00394-019-02121-2
   Weissmann G, 2010, FASEB J, V24, P4129, DOI 10.1096/fj.10-1101ufm
   Wen HT, 2011, NAT IMMUNOL, V12, P408, DOI 10.1038/ni.2022
   Widmer RJ, 2015, AM J MED, V128, P229, DOI 10.1016/j.amjmed.2014.10.014
   Wong SW, 2009, J BIOL CHEM, V284, P27384, DOI 10.1074/jbc.M109.044065
   Wongwarawipat T, 2018, ENDOCR METAB IMMUNE, V18, P51, DOI 10.2174/1871530317666171116103618
   Wysoczanski T, 2016, CURR MED CHEM, V23, P816, DOI 10.2174/0929867323666160122114439
   Xydakis AM, 2004, J CLIN ENDOCR METAB, V89, P2697, DOI 10.1210/jc.2003-031826
   Yang XF, 2012, NUTR RES, V32, P285, DOI 10.1016/j.nutres.2011.12.016
   Yang ZG, 2010, J BIOL CHEM, V285, P19051, DOI 10.1074/jbc.M110.123620
   Yang ZH, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201900120
   Yao DW, 2016, J DAIRY SCI, V99, P6391, DOI 10.3168/jds.2016-10990
   Zaki SM, 2019, FOLIA MORPHOL, V78, P124, DOI 10.5603/FM.a2018.0063
   Zhang SB, 2005, BIOCHEM J, V388, P135, DOI 10.1042/BJ20041554
   Zhang YY, 2018, COMPR PHYSIOL, V8, P351, DOI 10.1002/cphy.c160041
   Zheng Y, 1999, NAT GENET, V23, P268, DOI 10.1038/15446
NR 193
TC 158
Z9 165
U1 10
U2 92
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2021
VL 22
IS 1
AR 330
DI 10.3390/ijms22010330
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA PP9FC
UT WOS:000606158500001
PM 33396940
OA Green Accepted, gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Iturriaga, R
   Del Rio, R
   Idiaquez, J
   Somers, VK
AF Iturriaga, Rodrigo
   Del Rio, Rodrigo
   Idiaquez, Juan
   Somers, Virend K.
TI Carotid body chemoreceptors, sympathetic neural activation, and
   cardiometabolic disease
SO BIOLOGICAL RESEARCH
LA English
DT Review
DE Autonomic dysfunction; Carotid body; Heart failure; Metabolic syndrome;
   Obstructive sleep apnea; Sympathetic activation
ID CHRONIC INTERMITTENT HYPOXIA; OBSTRUCTIVE SLEEP-APNEA; OXIDATIVE STRESS;
   HEART-FAILURE; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; CARDIORESPIRATORY
   ALTERATIONS; CHEMOREFLEX SENSITIVITY; INFLAMMATORY CYTOKINES; AUTONOMIC
   CONTROL
AB The carotid body (CB) is the main peripheral chemoreceptor that senses the arterial PO2, PCO2 and pH. In response to hypoxemia, hypercapnia and acidosis, carotid chemosensory discharge elicits reflex respiratory, autonomic and cardiovascular adjustments. The classical construct considers the CB as the main peripheral oxygen sensor, triggering reflex physiological responses to acute hypoxemia and facilitating the ventilatory acclimation to chronic hypoxemia at high altitude. However, a growing body of experimental evidence supports the novel concept that an abnormally enhanced CB chemosensory input to the brainstem contributes to overactivation of the sympathetic nervous system, and consequent pathology. Indeed, the CB has been implicated in several diseases associated with increases in central sympathetic outflow. These include hypertension, heart failure, sleep apnea, chronic obstructive pulmonary disease and metabolic syndrome. Indeed, ablation of the CB has been proposed for the treatment of severe and resistant hypertension in humans. In this review, we will analyze and discuss new evidence supporting an important role for the CB chemoreceptor in the progression of autonomic and cardiorespiratory alterations induced by heart failure, obstructive sleep apnea, chronic obstructive pulmonary disease and metabolic syndrome.
C1 [Iturriaga, Rodrigo] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Lab Neurobiol, Alameda 340, Santiago, Chile.
   [Del Rio, Rodrigo] Univ Autonoma Chile, Ctr Invest Biomed, Lab Cardioresp Control, Santiago, Chile.
   [Del Rio, Rodrigo] Univ Cient Sur, Direcc Invest, Lima, Peru.
   [Idiaquez, Juan] Univ Valparaiso, Catedra Neurol, Escuela Med, Valparaiso, Chile.
   [Somers, Virend K.] Mayo Clin, Div Cardiovasc Dis, Rochester, MN USA.
C3 Pontificia Universidad Catolica de Chile; Universidad Autonoma de Chile;
   Universidad Cientifica del Sur (CIENTIFICA); Universidad de Valparaiso;
   Mayo Clinic
RP Iturriaga, R (corresponding author), Pontificia Univ Catolica Chile, Fac Ciencias Biol, Lab Neurobiol, Alameda 340, Santiago, Chile.
EM riturriaga@bio.puc.cl
RI Iturriaga, Rodrigo/AAG-1020-2020; Del Rio, Rodrigo/AAF-8763-2020
OI Iturriaga, Rodrigo/0000-0001-5387-9897
FU FONDECYT [1150040, 1140275]; National Heart Lung and Blood Institute NIH
   [R01 HL65176]; NIH Roadmap for Medical Research
FX RI supported by FONDECYT 1150040, RDR by FONDECYT 1140275. VKS is
   supported by National Heart Lung and Blood Institute NIH R01 HL65176, a
   component of the National Institutes of Health (NIH) and the NIH Roadmap
   for Medical Research. Its contents are solely the responsibility of the
   authors and do not necessarily represent the official view of NCRR or
   NIH.
CR Abbott SBG, 2013, J NEUROSCI, V33, P3164, DOI 10.1523/JNEUROSCI.1046-12.2013
   Andreas S, 2005, CHEST, V128, P3618, DOI 10.1378/chest.128.5.3618
   Arnardottir ES, 2009, SLEEP, V32, P447, DOI 10.1093/sleep/32.4.447
   Baguet JP, 2012, NAT REV CARDIOL, V9, P679, DOI 10.1038/nrcardio.2012.141
   Chen L, 2005, AM J RESP CRIT CARE, V172, P915, DOI 10.1164/rccm.200504-560OC
   Christou K, 2003, SLEEP MED, V4, P225, DOI 10.1016/S1389-9457(02)00253-8
   Cistulli PA., 1994, Sleep and Breathing, P405
   Cohn JN, 2000, J AM COLL CARDIOL, V35, P569, DOI 10.1016/S0735-1097(99)00630-0
   Del Rio R, 2010, EUR RESPIR J, V36, P143, DOI 10.1183/09031936.00158109
   Del Rio R, 2015, EXP PHYSIOL, V100, P121, DOI 10.1113/expphysiol.2014.079350
   Del Rio R, 2015, EXP PHYSIOL, V100, P136, DOI 10.1113/expphysiol.2014.079566
   Del Rio R, 2013, J AM COLL CARDIOL, V62, P2422, DOI 10.1016/j.jacc.2013.07.079
   Del Rio R, 2013, J APPL PHYSIOL, V114, P1141, DOI 10.1152/japplphysiol.01503.2012
   Del Rio R, 2012, EUR RESPIR J, V39, P1492, DOI 10.1183/09031936.00141511
   Del Rio R, 2011, AM J PHYSIOL-LUNG C, V301, pL702, DOI 10.1152/ajplung.00128.2011
   Del Rio R, 2011, BRAIN RES, V1395, P74, DOI 10.1016/j.brainres.2011.04.028
   Dempsey JA, 2010, PHYSIOL REV, V90, P47, DOI 10.1152/physrev.00043.2008
   Dick TE, 2007, EXP PHYSIOL, V92, P87, DOI 10.1113/expphysiol.2006.035758
   DIMSDALE JE, 1995, SLEEP, V18, P377
   Ding YF, 2011, J PHYSIOL-LONDON, V589, P245, DOI 10.1113/jphysiol.2010.200584
   Dumitrascu R, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/234631
   Eckert Danny J, 2008, Proc Am Thorac Soc, V5, P144, DOI 10.1513/pats.200707-114MG
   Fatouleh R, 2011, J PHYSIOL-LONDON, V589, P4997, DOI 10.1113/jphysiol.2011.210534
   Feng J, 2008, CHINESE MED J-PEKING, V121, P1732, DOI 10.1097/00029330-200809010-00026
   Fenik Victor B, 2012, Front Neurol, V3, P51, DOI 10.3389/fneur.2012.00051
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   FLETCHER EC, 1992, J APPL PHYSIOL, V72, P1978, DOI 10.1152/jappl.1992.72.5.1978
   FRANCIS GS, 1989, AM HEART J, V118, P642, DOI 10.1016/0002-8703(89)90291-3
   Garvey JF, 2009, EUR RESPIR J, V33, P1195, DOI 10.1183/09031936.00111208
   Giannoni A, 2009, J AM COLL CARDIOL, V53, P1975, DOI 10.1016/j.jacc.2009.02.030
   Gonzalez C, 2007, RESP PHYSIOL NEUROBI, V157, P30, DOI 10.1016/j.resp.2007.01.016
   GONZALEZ C, 1994, PHYSIOL REV, V74, P829, DOI 10.1152/physrev.1994.74.4.829
   Gozal D, 2008, AM J RESP CRIT CARE, V177, P369, DOI 10.1164/rccm.200608-1190PP
   Greenberg HE, 1999, J APPL PHYSIOL, V86, P298, DOI 10.1152/jappl.1999.86.1.298
   Haack KKV, 2014, HYPERTENSION, V63, P1041, DOI 10.1161/HYPERTENSIONAHA.113.02535
   Hanly PJ, 1996, AM J RESP CRIT CARE, V153, P272, DOI 10.1164/ajrccm.153.1.8542128
   Heindl S, 2001, AM J RESP CRIT CARE, V164, P597, DOI 10.1164/ajrccm.164.4.2007085
   HOLTZ J, 1993, BASIC RES CARDIOL, V88, P183
   Huang JH, 2009, RESP PHYSIOL NEUROBI, V166, P102, DOI 10.1016/j.resp.2009.02.010
   Idiaquez J, 2014, SLEEP MED, V15, P1319, DOI 10.1016/j.sleep.2014.05.030
   Iturriaga R, 2005, BIOL RES, V38, P335
   Iturriaga R, 2004, BRAIN RES REV, V47, P46, DOI 10.1016/j.brainresrev.2004.05.007
   Iturriaga R, 2012, OXIDATIVE STRESS DIS, P71
   Iturriaga R, 2007, RESP PHYSIOL NEUROBI, V157, P130, DOI 10.1016/j.resp.2006.12.006
   Iturriaga R, 2015, EXP PHYSIOL, V100, P149, DOI 10.1113/expphysiol.2014.079525
   Iturriaga R, 2014, FRONT PHYSIOL, V5, DOI 10.3389/fphys.2014.00468
   Iturriaga R, 2009, CLIN EXP PHARMACOL P, V36, P1197, DOI 10.1111/j.1440-1681.2009.05213.x
   Jelic S, 2008, CIRCULATION, V117, P2270, DOI 10.1161/CIRCULATIONAHA.107.741512
   Koyama Y, 2000, DIABETES, V49, P1434, DOI 10.2337/diabetes.49.9.1434
   Lai CJ, 2006, J APPL PHYSIOL, V100, P1974, DOI 10.1152/japplphysiol.01051.2005
   Lam SY, 2008, HISTOCHEM CELL BIOL, V130, P549, DOI 10.1007/s00418-008-0437-4
   Lam SY, 2008, HISTOL HISTOPATHOL, V23, P271, DOI 10.14670/HH-23.271
   Lavie L, 2003, SLEEP MED REV, V7, P35, DOI 10.1053/smrv.2002.0261
   Lehnen AM, 2013, AUTON NEUROSCI-BASIC, V176, P64, DOI 10.1016/j.autneu.2013.02.011
   Lévy P, 2008, EUR RESPIR J, V32, P1082, DOI 10.1183/09031936.00013308
   Lin M, 2007, AM J PHYSIOL-HEART C, V293, pH997, DOI 10.1152/ajpheart.01124.2006
   Lloyd-Jones DM, 2002, CIRCULATION, V106, P3068, DOI 10.1161/01.CIR.0000039105.49749.6F
   Macefield VG, 2012, FRONT PHYSIOL, V3, DOI 10.3389/fphys.2012.00153
   Marcus NJ, 2014, FRONT PHYSIOL, V5, DOI 10.3389/fphys.2014.00438
   Marin JM, 2005, LANCET, V365, P1046, DOI 10.1016/S0140-6736(05)71141-7
   Narkiewicz K, 1999, CIRCULATION, V99, P1183, DOI 10.1161/01.CIR.99.9.1183
   Narkiewicz K, 1998, CIRCULATION, V98, P772, DOI 10.1161/01.CIR.98.8.772
   Narkiewicz K, 1998, CIRCULATION, V97, P943
   Narkiewicz K, 1998, CIRCULATION, V98, P1071, DOI 10.1161/01.CIR.98.11.1071
   Nimbkar NV, 2005, MED HYPOTHESES, V65, P1067, DOI 10.1016/j.mehy.2005.06.023
   Nurse CA, 2005, AUTON NEUROSCI-BASIC, V120, P1, DOI 10.1016/j.autneu.2005.04.008
   Pardal R, 2002, NAT NEUROSCI, V5, P197, DOI 10.1038/nn812
   Paton JFR, 2013, HYPERTENSION, V61, P5, DOI 10.1161/HYPERTENSIONAHA.111.00064
   Peng YJ, 2009, J NEUROSCI, V29, P4903, DOI 10.1523/JNEUROSCI.4768-08.2009
   Peng YJ, 2004, J APPL PHYSIOL, V96, P1236, DOI 10.1152/japplphysiol.00820.2003
   Peng YJ, 2003, P NATL ACAD SCI USA, V100, P10073, DOI 10.1073/pnas.1734109100
   Peng YJ, 2003, J APPL PHYSIOL, V94, P2342, DOI 10.1152/japplphysiol.00613.2002
   Peppard PE, 2000, NEW ENGL J MED, V342, P1378, DOI 10.1056/NEJM200005113421901
   PFEFFER MA, 1990, CIRCULATION, V81, P1161, DOI 10.1161/01.CIR.81.4.1161
   Ponikowski P, 2001, CIRCULATION, V104, P544, DOI 10.1161/hc3101.093699
   Porzionato A, 2013, HYPERTENSION, V61, pE57, DOI 10.1161/HYPERTENSIONAHA.113.01248
   Powell FL, 2009, AM J PHYSIOL-LUNG C, V296, pL156, DOI 10.1152/ajplung.90597.2008
   Prabhakar NR, 2007, EXP PHYSIOL, V92, P39, DOI 10.1113/expphysiol.2006.036434
   Prabhakar NR, 2005, CLIN EXP PHARMACOL P, V32, P447, DOI 10.1111/j.1440-1681.2005.04209.x
   Raupach T, 2008, EUR RESPIR J, V32, P387, DOI 10.1183/09031936.00109607
   Reeves SR, 2003, J APPL PHYSIOL, V95, P1767, DOI 10.1152/japplphysiol.00759.2002
   Remme WJ, 2001, EUR HEART J, V22, P1527, DOI 10.1053/euhj.2001.2783
   Rey S, 2004, J PHYSIOL-LONDON, V560, P577, DOI 10.1113/jphysiol.2004.072033
   Rey S, 2008, AM J PHYSIOL-REG I, V295, pR28, DOI 10.1152/ajpregu.00070.2008
   Rey S, 2007, J HISTOCHEM CYTOCHEM, V55, P167, DOI 10.1369/jhc.6A7079.2006
   Ribeiro MJ, 2013, DIABETES, V62, P2905, DOI 10.2337/db12-1463
   Ryan S, 2009, THORAX, V64, P631, DOI 10.1136/thx.2008.105577
   Savransky V, 2007, AM J RESP CRIT CARE, V175, P1290, DOI 10.1164/rccm.200612-1771OC
   Schultz H D, 2000, Heart Fail Rev, V5, P45
   Schultz HD, 2015, ADV EXP MED BIOL, V860, P167, DOI 10.1007/978-3-319-18440-1_19
   Schulz R, 2008, Pneumologie, V62, P18, DOI 10.1055/s-2007-980132
   Shiomi T, 1996, SLEEP, V19, P370, DOI 10.1093/sleep/19.5.370
   Smith MM, 2012, J PHYSIOL-LONDON, V590, P1787, DOI 10.1113/jphysiol.2011.221036
   Somers VK, 2008, J AM COLL CARDIOL, V52, P686, DOI 10.1016/j.jacc.2008.05.002
   SOMERS VK, 1995, J CLIN INVEST, V96, P1897, DOI 10.1172/JCI118235
   Sun SY, 1999, J APPL PHYSIOL, V86, P1273, DOI 10.1152/jappl.1999.86.4.1273
   Toschi-Dias E, 2013, AM J PHYSIOL-HEART C, V304, pH1038, DOI 10.1152/ajpheart.00848.2012
   Trombetta IC, 2013, SLEEP, V36, P41, DOI 10.5665/sleep.2298
   van Gestel Arnoldus J R, 2010, J Thorac Dis, V2, P215, DOI 10.3978/j.issn.2072-1439.2010.02.04.5
   Weiss JW, 2007, EXP PHYSIOL, V92, P21, DOI 10.1113/expphysiol.2006.035733
   YOUNG T, 1993, NEW ENGL J MED, V328, P1230, DOI 10.1056/NEJM199304293281704
   Zoccal DB, 2008, J PHYSIOL-LONDON, V586, P3253, DOI 10.1113/jphysiol.2008.154187
NR 102
TC 72
Z9 77
U1 1
U2 31
PU SOC BIOLGIA CHILE
PI SANTIAGO
PA CASILLA 16164, SANTIAGO 9, CHILE
SN 0716-9760
EI 0717-6287
J9 BIOL RES
JI Biol. Res.
PD FEB 26
PY 2016
VL 49
AR 13
DI 10.1186/s40659-016-0073-8
PG 9
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA DF2VT
UT WOS:000371203200001
PM 26920146
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chaldakov, GN
   Fiore, M
   Tonchev, AB
   Aloe, L
AF Chaldakov, G. N.
   Fiore, M.
   Tonchev, A. B.
   Aloe, L.
TI Adipopharmacology, a novel drug discovery approach: A metabotrophic
   perspective
SO LETTERS IN DRUG DESIGN & DISCOVERY
LA English
DT Article
DE adipobiology; BDNF; CNTF; metallothioneins; metabotrophins; NGF
ID NERVE GROWTH-FACTOR; ENDOPLASMIC-RETICULUM STRESS; NEUROTROPHIC FACTOR;
   METABOLIC SYNDROME; ADIPOSE-TISSUE; INSULIN-RESISTANCE; SIGNALING
   PATHWAY; GENE-EXPRESSION; PC12 CELLS; IN-VITRO
AB "Adipopharmacology" connotes the adipotargeting studies aimed at drug discovery. Here we focus on adipopharmacology of nerve growth factor, brain-derived neurotrophic factor, ciliary neurotrophic factor and metallothioneins. Because these factors improve glucose, lipid and antioxidant metabolism, we named them metabotrophic factors (metabotrophins).
C1 Med Univ, Div Cell Biol, BG-9002 Varna, Bulgaria.
   CNR, European Brain Res Inst, Inst Neurobiol & Mol Med, NGF Sect, I-00143 Rome, Italy.
C3 Medical University Varna; Consiglio Nazionale delle Ricerche (CNR)
RP Chaldakov, GN (corresponding author), Med Univ, Div Cell Biol, BG-9002 Varna, Bulgaria.
EM chaldakov@yahoo.com
RI Fiore, Marco/GLT-0780-2022; Tonchev, Anton/LKK-5568-2024
OI fiore, marco/0000-0001-6806-9715
CR ALOE L, 2004, NGF RELATED MOL HLTH, P146
   Altar CA, 1999, TRENDS PHARMACOL SCI, V20, P59, DOI 10.1016/S0165-6147(99)01309-7
   Bailey Clifford J, 2005, Curr Diab Rep, V5, P353, DOI 10.1007/s11892-005-0093-1
   Blüher S, 2004, DIABETES, V53, P2787, DOI 10.2337/diabetes.53.11.2787
   Boss O, 2006, EXPERT OPIN THER TAR, V10, P119, DOI 10.1517/14728222.10.1.119
   Bulló M, 2005, AM J PHYSIOL-ENDOC M, V289, pE62, DOI 10.1152/ajpendo.00008.2005
   Chaldakov GN, 2004, PROG BRAIN RES, V146, P279, DOI 10.1016/S0079-6123(03)46018-4
   Chaldakov GN, 2003, CURR PHARM DESIGN, V9, P1023, DOI 10.2174/1381612033455152
   CHALDAKOV GN, 2003, MED SCI MONITOR, V21, pH19
   Chen C, 2003, NAT BIOTECHNOL, V21, P294, DOI 10.1038/nbt795
   CORSI MM, 2006, IN PRESS ATHEROSCLER
   Do MS, 2002, HORM METAB RES, V34, P348, DOI 10.1055/s-2002-33254
   DREYON CA, 2005, BIOCHIM BIOPHYS ACTA, V174, P287
   EMANUELE E, 2006, IN PRESS PSYCHONEURO
   Esch T, 2005, NEUROENDOCRINOL LETT, V26, P175
   FRIDE E, 2006, IN PRESS CURR MED CH
   Fuenzalida KM, 2005, J BIOL CHEM, V280, P9604, DOI 10.1074/jbc.M409447200
   FURUKAWA S, 1999, BIOMED REV, V10, P45
   Geroldi D, 2006, MED HYPOTHESES, V67, P195, DOI 10.1016/j.mehy.2006.02.001
   HANSENALGENSTAE.N, 2005, HISTOCHEM CELL BIOL, V29, P1
   Harding HP, 2005, CELL METAB, V2, P361, DOI 10.1016/j.cmet.2005.11.005
   Hotamisligil GS, 2005, DIABETES, V54, pS73, DOI 10.2337/diabetes.54.suppl_2.S73
   Ioannides-Demos LL, 2005, DRUGS, V65, P1391, DOI 10.2165/00003495-200565100-00006
   Kokai LE, 2005, PLAST RECONSTR SURG, V116, P1453, DOI 10.1097/01.prs.0000182570.62814.e3
   Kosacka J, 2006, J NEUROSCI RES, V83, P1160, DOI 10.1002/jnr.20811
   Kotzka J, 2004, EXPERT OPIN THER TAR, V8, P141, DOI 10.1517/eott.8.2.141.30248
   Lambert PD, 2001, P NATL ACAD SCI USA, V98, P4652, DOI 10.1073/pnas.061034298
   Langin D, 2006, PHARMACOL RES, V53, P482, DOI 10.1016/j.phrs.2006.03.009
   LEVIMONTALCINI R, 1987, SCIENCE, V237, P1154, DOI 10.1126/science.3306916
   LICASTRO F, 2006, IN PRESS ARCH GERONT
   Manni L, 2005, INT J CARDIOL, V102, P169, DOI 10.1016/j.ijcard.2004.10.041
   Mattson MP, 2005, ANNU REV NUTR, V25, P237, DOI 10.1146/annurev.nutr.25.050304.092526
   Miao G, 2006, TRANSPLANTATION, V81, P519, DOI 10.1097/01.tp.0000200320.16723.b3
   Molteni R, 2002, NEUROSCIENCE, V112, P803, DOI 10.1016/S0306-4522(02)00123-9
   Mora S, 2002, DIABETES-METAB RES, V18, P345, DOI 10.1002/dmrr.321
   Moran CS, 1997, ARTERIOSCL THROM VAS, V17, P1267, DOI 10.1161/01.ATV.17.7.1267
   Nambu T, 2005, REGUL PEPTIDES, V132, P17, DOI 10.1016/j.regpep.2005.07.006
   Oike Y, 2005, TRENDS MOL MED, V11, P473, DOI 10.1016/j.molmed.2005.08.002
   Okamoto Y, 2006, CLIN SCI, V110, P267, DOI 10.1042/CS20050182
   Ott V, 2004, MOL CELL ENDOCRINOL, V224, P21, DOI 10.1016/j.mce.2004.07.006
   Peet M, 2004, PROSTAG LEUKOTR ESS, V70, P417, DOI 10.1016/j.plefa.2003.12.019
   Penkowa M, 2006, FEBS J, V273, P1857, DOI 10.1111/j.1742-4658.2006.05207.x
   Podratz JL, 2005, NEUROTOXICOLOGY, V26, P343, DOI 10.1016/j.neuro.2005.01.003
   Rios M, 2001, MOL ENDOCRINOL, V15, P1748, DOI 10.1210/me.15.10.1748
   Robenek H, 2005, J LIPID RES, V46, P1331, DOI 10.1194/jlr.M400323-JLR200
   Scheede-Bergdahl C, 2005, DIABETES, V54, P3089, DOI 10.2337/diabetes.54.11.3089
   Shimoke K, 2005, NEUROSCI LETT, V389, P124, DOI 10.1016/j.neulet.2005.07.030
   Shimoke K, 2004, BRAIN RES, V1028, P105, DOI 10.1016/j.brainres.2004.09.005
   Song Y, 2005, AM J PATHOL, V167, P17, DOI 10.1016/S0002-9440(10)62949-5
   TILG H, 2006, IN PRESS CURR MED CH
   TORE F, 2006, IN PRESS CURR MED CH
   Trayhurn P, 2004, BRIT J NUTR, V92, P347, DOI 10.1079/BJN20041213
   Turban S, 2001, J CELL BIOCHEM, V82, P666, DOI 10.1002/jcb.1187
   Viguerie N, 2005, BIOCHIMIE, V87, P117, DOI 10.1016/j.biochi.2004.12.011
   Weyer C, 2001, J CLIN ENDOCR METAB, V86, P1930, DOI 10.1210/jc.86.5.1930
   Wood IS, 2005, HORM METAB RES, V37, P474, DOI [10.1055/s-2005-870325, 10.1055/s-870325]
   Yeo GSH, 2004, NAT NEUROSCI, V7, P1187, DOI 10.1038/nn1336
   Zvonic S, 2003, J BIOL CHEM, V278, P2228, DOI 10.1074/jbc.M205871200
NR 58
TC 9
Z9 9
U1 0
U2 1
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1808
EI 1875-628X
J9 LETT DRUG DES DISCOV
JI Lett. Drug Des. Discov.
PD SEP
PY 2006
VL 3
IS 7
BP 503
EP 505
DI 10.2174/157018006778194835
PG 3
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 081GD
UT WOS:000240304300009
DA 2025-06-11
ER

PT J
AU Sabanovic, S
   Ljiljana, MT
   Babic, F
   Vadovsky, M
   Paralic, J
   Vcev, A
   Holzinger, A
AF Sabanovic, Sefket
   Ljiljana, Majnaric Trtica
   Babic, Frantisek
   Vadovsky, Michal
   Paralic, Jan
   Vcev, Aleksandar
   Holzinger, Andreas
TI Metabolic syndrome in hypertensive women in the age of menopause: a case
   study on data from general practice electronic health records
SO BMC MEDICAL INFORMATICS AND DECISION MAKING
LA English
DT Article
DE General practice; Research; Routine data; Electronic health records;
   Computer methods for data anlysis; Menopausal women; Hypertension;
   Metabolic syndrome
ID CARDIOVASCULAR-DISEASE; PRIMARY-CARE; GENDER-DIFFERENCES; RESEARCH
   NETWORKS; MIDLIFE WOMEN; ASSOCIATION; TRANSITION; OVERWEIGHT;
   DIFFERENCE; MANAGEMENT
AB Background: There is potential for medical research on the basis of routine data used from general practice electronic health records (GP eHRs), even in areas where there is no common GP research platform. We present a case study on menopausal women with hypertension and metabolic syndrome (MS). The aims were to explore the appropriateness of the standard definition of MS to apply to this specific, narrowly defined population group and to improve recognition of women at high CV risk.
   Methods: We investigated the possible uses offered by available data from GP eHRs, completed with patients interview, in goal of the study, using a combination of methods. For the sample of 202 hypertensive women, 47-59 years old, a data set was performed, consisted of a total number of 62 parameters, 50 parameters used from GP eHRs. It was analysed by using a mixture of methods: analysis of differences, cutoff values, graphical presentations, logistic regression and decision trees.
   Results: The age range found to best match the emergency of MS was 51-55 years. Deviations from the definition of MS were identified: a larger cut-off value of the waist circumference measure (89 vs 80 cm) and parameters BMI and total serum cholesterol perform better as components of MS than the standard parameters waist circumference and HDL-cholesterol. The threshold value of BMI at which it is expected that most of hypertensive menopausal women have MS, was found to be 25.5. The other best means for recognision of women with MS include triglycerides above the threshold of 1.7 mmol/L and information on statins use. Prevention of CVD should focus on women with a new onset diabetes and comorbidities of a long-term hypertension with anxiety/depression.
   Conclusions: The added value of this study goes beyond the current paradigm on MS. Results indicate characteristics of MS in a narrowly defined, specific population group. A comprehensive view has been enabled by using heterogenoeus data and a smart combination of various methods for data analysis. The paper shows the feasibility of this research approach in routine practice, to make use of data which would otherwise not be used for research.
C1 [Sabanovic, Sefket; Ljiljana, Majnaric Trtica; Vcev, Aleksandar] Josip Juraj Strossmayer Univ, Fac Med, Dept Internal Med Family Med & Hist Med, Huttlerova 10b, Osijek 31000, Croatia.
   [Babic, Frantisek; Vadovsky, Michal; Paralic, Jan] Tech Univ Kosice, Fac Elect Engn & Informat, Dept Cybernet & Artificial Intelligence, Letna 9-B, Kosice 04200, Slovakia.
   [Holzinger, Andreas] Med Univ Graz, Inst Med Informat Stat, Auenbruggerpl 2-5, A-8036 Graz, Austria.
C3 University of JJ Strossmayer Osijek; Technical University Kosice;
   Medical University of Graz
RP Holzinger, A (corresponding author), Med Univ Graz, Inst Med Informat Stat, Auenbruggerpl 2-5, A-8036 Graz, Austria.
EM andreas.holzinger@medunigraz.at
RI Babic, Frantisek/I-3890-2014; MAJNARIĆ, LJILJANA/JCO-5151-2023;
   HOLZINGER, Andreas/E-9530-2010; Paralic, Jan/H-5393-2013
OI HOLZINGER, Andreas/0000-0002-6786-5194; Babic,
   Frantisek/0000-0003-2225-5955; Paralic, Jan/0000-0002-4603-0411
FU Slovak Grant Agency of the Ministry of Education; Academy of Science of
   the Slovak Republic [1/0493/16]; Slovak Research and Development Agency
   [APVV-16-0213]
FX This work is approved by the University of Osijek Common Fund, through
   cooperative agreements. The views presented here are solely the
   responsibility of the authors and do not represent the official views of
   the Faculty of Medicine and the University of Osijek. The work was
   partially supported by the Slovak Grant Agency of the Ministry of
   Education and Academy of Science of the Slovak Republic under grant no.
   1/0493/16 and The Slovak Research and Development Agency under grant no.
   APVV-16-0213.
CR Rojas LBA, 2013, DIABETOL METAB SYNDR, V5, DOI 10.1186/1758-5996-5-6
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   [Anonymous], EUR DEF GEN PRACT FA
   [Anonymous], J CLIN ENDOCRINOL ME
   Babic Frantisek, 2014, Information Technology in Bio- and Medical Informatics. 5th International Conference (ITBAM 2014). Proceedings: LNCS 8649, P118, DOI 10.1007/978-3-319-10265-8_11
   Beaser RS, 2007, CIRCULATION, V115, P1812, DOI 10.1161/CIRCULATIONAHA.106.673616
   Benchimol EI, 2015, PLOS MED, V12, DOI 10.1371/journal.pmed.1001885
   Carey Iain M, 2003, BMC Fam Pract, V4, P14, DOI 10.1186/1471-2296-4-14
   Chae CU, 2011, OBSTET GYN CLIN N AM, V38, P477, DOI 10.1016/j.ogc.2011.05.005
   Churilla JR, 2008, AM J LIFESTYLE MED, V2, P118, DOI 10.1177/1559827607311981
   Davy KP, 2004, AM J PHYSIOL-REG I, V286, pR803, DOI 10.1152/ajpregu.00707.2003
   De Clercq E, 2006, STUD HEALTH TECHNOL, V124, P181
   de Lusignan S, 2006, FAM PRACT, V23, P253, DOI 10.1093/fampra/cmi106
   De Maeseneer JM, 2004, ANN FAM MED S2, V2, P17
   Denaxas SC, 2012, INT J EPIDEMIOL, V41, P1625, DOI 10.1093/ije/dys188
   Devaraj S, 2011, CURR ATHEROSCLER REP, V13, P31, DOI 10.1007/s11883-010-0143-2
   Dratva J, 2009, MENOPAUSE, V16, P385, DOI 10.1097/gme.0b013e31818aefef
   Eckel RH, 2010, LANCET, V375, P181, DOI 10.1016/S0140-6736(09)61794-3
   Fried LP, 2004, J GERONTOL A-BIOL, V59, P255
   Garcia-Gil M Del Mar, 2011, Inform Prim Care, V19, P135
   Gijsen R, 2006, PUBLIC HEALTH, V120, P923, DOI 10.1016/j.puhe.2006.06.005
   Ginsberg Henry N, 2009, J Cardiometab Syndr, V4, P113, DOI 10.1111/j.1559-4572.2008.00044.x
   Hall MH, 2012, SLEEP, V35, P783, DOI 10.5665/sleep.1874
   Harlow SD, 2012, CLIMACTERIC, V15, P105, DOI [10.1210/jc.2011-3362, 10.3109/13697137.2011.650656, 10.1016/j.fertnstert.2012.01.128, 10.1097/gme.0b013e31824d8f40]
   Holzinger A, 2018, LECT NOTES COMPUT SC, V11015, P1, DOI 10.1007/978-3-319-99740-7_1
   Inker LA, 2014, AM J KIDNEY DIS, V63, P713, DOI 10.1053/j.ajkd.2014.01.416
   Julius S, 2000, HYPERTENSION, V35, P807, DOI 10.1161/01.HYP.35.3.807
   Kahl KG, 2015, BRAIN BEHAV, V5, DOI 10.1002/brb3.306
   Kearney PM, 2005, LANCET, V365, P217, DOI 10.1016/S0140-6736(05)70151-3
   Khan NF, 2010, BRIT J GEN PRACT, V60, DOI 10.3399/bjgp10X483562
   King AC, 2003, ADDICT BEHAV, V28, P171, DOI 10.1016/S0306-4603(01)00264-7
   Kjeldsen SE, 2008, J HYPERTENS, V26, P2064, DOI 10.1097/HJH.0b013e32830c45c3
   Lechat P, 1999, LANCET, V353, P9
   Levey AS, 2006, ANN INTERN MED, V145, P247, DOI 10.7326/0003-4819-145-4-200608150-00004
   Ludwick DA, 2009, INT J MED INFORM, V78, P22, DOI 10.1016/j.ijmedinf.2008.06.005
   Majnaric-Trtica Ljiljana, 2011, Prim Health Care Res Dev, V12, P310, DOI 10.1017/S1463423611000089
   Matthews KA, 2009, J AM COLL CARDIOL, V54, P2366, DOI 10.1016/j.jacc.2009.10.009
   McFadden D., 1973, Frontiers in Econometrics
   Mesch VR, 2006, CLIMACTERIC, V9, P40, DOI 10.1080/13697130500487331
   Montez JK, 2016, J GERONTOL B-PSYCHOL, V71, P1097, DOI 10.1093/geronb/gbw014
   Mosca L, 2011, CIRCULATION, V124, P2145, DOI 10.1161/CIRCULATIONAHA.110.968792
   Mule G, 2006, Minerva Cardioangiol, V54, P173
   Muntingh ADT, 2011, BMC FAM PRACT, V12, DOI 10.1186/1471-2296-12-66
   Nagahori M, 2010, J GASTROENTEROL, V45, P1008, DOI 10.1007/s00535-010-0247-z
   Nashar K, 2014, DIABET METAB SYND OB, V7, P421, DOI 10.2147/DMSO.S45183
   Nutting PA, 1999, JAMA-J AM MED ASSOC, V281, P686, DOI 10.1001/jama.281.8.686
   Nuzzo A, 2010, EXPERT REV CARDIOVAS, V8, P1541, DOI [10.1586/erc.10.147, 10.1586/ERC.10.147]
   Okkes IM, 2002, J FAM PRACTICE, V51, P31
   Olszanecka A, 2014, ADV MED SCI-POLAND, V59, P232, DOI 10.1016/j.advms.2013.12.002
   Onat A, 2005, METABOLISM, V54, P800, DOI 10.1016/j.metabol.2005.01.025
   Panza F, 2010, J ALZHEIMERS DIS, V21, P691, DOI 10.3233/JAD-2010-091669
   Patil P.R., 2012, Indian Streams Research Journal, V1, P1
   Poljicanin Tamara, 2005, Acta Medica Croatica, V59, P185
   Rasmussen LV, 2014, J CARDIOVASC TRANSL, V7, P607, DOI 10.1007/s12265-014-9579-z
   Regitz-Zagrosek V, 2006, CLIN RES CARDIOL, V95, P136, DOI 10.1007/s00392-006-0351-5
   Reiner Z, 2011, EUR HEART J, V32, P1769, DOI [10.1016/j.atherosclerosis.2011.06.012, 10.1093/eurheartj/ehr158]
   Rodríguez LAG, 1998, BRIT J CLIN PHARMACO, V45, P419
   Ross WA, 2004, AUTOTESTCON 2004, PROCEEDINGS, P2
   Rosser WW, 1999, LANCET, V353, P661, DOI 10.1016/S0140-6736(98)09103-X
   Rumsfeld JS, 2016, NAT REV CARDIOL, V13, P350, DOI 10.1038/nrcardio.2016.42
   Rydén L, 2013, EUR HEART J, V34, P3035, DOI 10.1093/eurheartj/eht108
   Salive ME, 2013, EPIDEMIOL REV, V35, P75, DOI 10.1093/epirev/mxs009
   Sattar N, 2010, LANCET, V375, P735, DOI 10.1016/S0140-6736(09)61965-6
   SHAPIRO SS, 1965, BIOMETRIKA, V52, P591, DOI 10.1093/biomet/52.3-4.591
   Starfield B, 2000, JAMA-J AM MED ASSOC, V284, P483, DOI 10.1001/jama.284.4.483
   STARFIELD B, 1994, LANCET, V344, P1129, DOI 10.1016/S0140-6736(94)90634-3
   STEWART DE, 1993, INT J PSYCHIAT MED, V23, P157, DOI 10.2190/026V-69M0-C0FF-7V7Y
   Tamashiro KLK, 2011, ANN NY ACAD SCI, V1231, P46, DOI 10.1111/j.1749-6632.2011.06134.x
   Thiru K, 2003, BMJ-BRIT MED J, V326, P1070, DOI 10.1136/bmj.326.7398.1070
   Thomas F, 2005, HYPERTENSION, V46, P654, DOI 10.1161/01.HYP.0000184282.51550.00
   Toalson Patrick, 2004, Prim Care Companion J Clin Psychiatry, V6, P152
   Toker S, 2005, DIABETES-METAB RES, V21, P197, DOI 10.1002/dmrr.502
   Tracy RP, 2003, INT J CLIN PRACT, P10
   Trtica-Majnaric L, 2010, J BIOMED INFORM, V43, P774, DOI 10.1016/j.jbi.2010.04.011
   van Vliet-Ostaptchouk JV, 2014, BMC ENDOCR DISORD, V14, DOI 10.1186/1472-6823-14-9
   van Weel C, 1999, LANCET, V353, P916, DOI 10.1016/S0140-6736(98)08024-6
   Vryonidou A, 2015, EUR J ENDOCRINOL, V173, pR153, DOI 10.1530/EJE-15-0275
   WELCH BL, 1951, BIOMETRIKA, V38, P330, DOI 10.1093/biomet/38.3-4.330
   Yildirim P, 2014, BMC BIOINFORM S6, V15, P7
   Yin JJ, 2014, STAT MED, V33, P1426, DOI 10.1002/sim.6046
   Zadhoush F, 2015, J RES MED SCI, V20, P763, DOI 10.4103/1735-1995.168383
   Zreikat HH, 2014, METABOLISM, V63, P392, DOI 10.1016/j.metabol.2013.11.006
NR 83
TC 10
Z9 10
U1 1
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6947
J9 BMC MED INFORM DECIS
JI BMC Med. Inform. Decis. Mak.
PD APR 2
PY 2018
VL 18
AR 24
DI 10.1186/s12911-018-0601-2
PG 18
WC Medical Informatics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Medical Informatics
GA GB2YU
UT WOS:000428922800001
PM 29609615
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sylvia, LG
   Ametrano, RM
   Nierenberg, AA
AF Sylvia, Louisa G.
   Ametrano, Rebecca M.
   Nierenberg, Andrew A.
TI Exercise Treatment for Bipolar Disorder: Potential Mechanisms of Action
   Mediated through Increased Neurogenesis and Decreased Allostatic Load
SO PSYCHOTHERAPY AND PSYCHOSOMATICS
LA English
DT Review
DE Exercise; Brain-derived neurotrophic factor; Allostatic load; Bipolar
   disorder
ID NEUROTROPHIC FACTOR BDNF; LITHIUM-TREATED PATIENTS; MAJOR DEPRESSION;
   METABOLIC SYNDROME; PHYSICAL-ACTIVITY; VAL66MET POLYMORPHISM;
   SYNAPTIC-PLASTICITY; UNIPOLAR DEPRESSION; RAT HIPPOCAMPUS; LIFE EVENTS
AB Outcomes are frequently suboptimal for patients with bipolar disorder who are treated with pharmacotherapy alone. Adjunct exercise has the potential to substantially improve acute and long-term outcomes, although how exercise would improve the course of bipolar disorder needs to be elucidated. We propose that exercise may improve mood and functioning by increasing neurogenesis and reducing allostatic load. We review data suggesting that exercise increases levels of brain-derived neurotrophic factor, which in turn increases neurogenesis and decreases allostatic load. Exercise as a psychosocial adjunct for bipolar disorder should be assessed with rigorous randomized clinical trials. Copyright (C) 2009 S. Karger AG, Basel
C1 [Sylvia, Louisa G.; Ametrano, Rebecca M.; Nierenberg, Andrew A.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard Medical School
RP Sylvia, LG (corresponding author), 50 Staniford St,Suite 580, Boston, MA 02114 USA.
EM lsylvia2@partners.org
RI Sylvia, Louisa/AAE-8027-2022; Nierenberg, ANierenberg/IAR-5549-2023
CR Anisman H, 2008, PROG NEUROBIOL, V85, P1, DOI 10.1016/j.pneurobio.2008.01.004
   [Anonymous], 2009, Human Brain Mapping
   [Anonymous], 2005, ACSMS GUID EX TEST P
   [Anonymous], BMC CARDIOVASC DISOR
   Araya AV, 2008, ENDOCRINE, V33, P300, DOI 10.1007/s12020-008-9090-x
   Artham SM, 2008, SOUTH MED J, V101, P262, DOI 10.1097/SMJ.0b013e318164dfa8
   Babyak M, 2000, PSYCHOSOM MED, V62, P633, DOI 10.1097/00006842-200009000-00006
   Basu R, 2004, BIPOLAR DISORD, V6, P314, DOI 10.1111/j.1399-5618.2004.00126.x
   Bearden CE, 2008, NEUROPSYCHOPHARMACOL, V33, P1229, DOI 10.1038/sj.npp.1301507
   Bearden CE, 2007, BIOL PSYCHIAT, V62, P7, DOI 10.1016/j.biopsych.2006.10.027
   Beyer JL, 2008, INT J GERIATR PSYCH, V23, P1271, DOI 10.1002/gps.2062
   Binder DK, 2004, GROWTH FACTORS, V22, P123, DOI 10.1080/08977190410001723308
   Blumenthal JA, 1999, ARCH INTERN MED, V159, P2349, DOI 10.1001/archinte.159.19.2349
   Blumenthal JA, 2007, PSYCHOSOM MED, V69, P587, DOI 10.1097/PSY.0b013e318148c19a
   Bremner JD, 2000, AM J PSYCHIAT, V157, P115, DOI 10.1176/ajp.157.1.115
   Bryan A, 2007, HEALTH PSYCHOL, V26, P30, DOI 10.1037/0278-6133.26.1.30
   Caffo E, 2008, PSYCHOTHER PSYCHOSOM, V77, P331, DOI 10.1159/000151386
   Campbell S, 2004, J PSYCHIATR NEUROSCI, V29, P417
   Chaldakov G N, 2001, Arch Physiol Biochem, V109, P357, DOI 10.1076/apab.109.3.357.9353
   Chaldakov GN, 2004, PROG BRAIN RES, V146, P279, DOI 10.1016/S0079-6123(03)46018-4
   Chaldakov GN, 2003, MED SCI MONIT, V9, P19
   Chue P, 2003, BIPOLAR DISORD, V5, P62, DOI 10.1111/j.1399-2406.2003.00063.x
   Cirulli F, 2009, NEUROSCI BIOBEHAV R, V33, P573, DOI 10.1016/j.neubiorev.2008.09.001
   Cohen AN, 2004, J AFFECT DISORDERS, V82, P143, DOI 10.1016/j.jad.2003.10.008
   Cotman CW, 2007, TRENDS NEUROSCI, V30, P464, DOI 10.1016/j.tins.2007.06.011
   Cunha ABM, 2006, NEUROSCI LETT, V398, P215, DOI 10.1016/j.neulet.2005.12.085
   Ding Q, 2006, NEUROSCIENCE, V140, P823, DOI 10.1016/j.neuroscience.2006.02.084
   Dixon T, 2004, PSYCHOL MED, V34, P811, DOI 10.1017/S0033291703001570
   Duman CH, 2008, BRAIN RES, V1199, P148, DOI 10.1016/j.brainres.2007.12.047
   Dunn AL, 2005, AM J PREV MED, V28, P1, DOI 10.1016/j.amepre.2004.09.003
   Edenfield TM, 2008, DISS ABSTR INT B, V68, P5566
   Elmslie JL, 2001, J CLIN PSYCHIAT, V62, P486, DOI 10.4088/JCP.v62n0614
   Ernst C, 2006, J PSYCHIATR NEUROSCI, V31, P84
   Fan J, 2008, NOVART FDN SYMP, V289, P87
   Fan J, 2008, NOVART FDN SYMP, V289
   Fan Jinbo, 2008, Novartis Found Symp, V289, P60
   Fava GA, 2009, PSYCHOTHER PSYCHOSOM, V78, P220, DOI 10.1159/000214443
   Frodl T, 2008, J PSYCHIATR NEUROSCI, V33, P423
   Frodl T, 2007, ARCH GEN PSYCHIAT, V64, P410, DOI 10.1001/archpsyc.64.4.410
   Frodl TS, 2008, ARCH GEN PSYCHIAT, V65, P1156, DOI 10.1001/archpsyc.65.10.1156
   Garcia-Portilla MP, 2009, J AFFECT DISORDERS, V115, P302, DOI 10.1016/j.jad.2008.09.008
   Guillin O, 2007, INT REV NEUROBIOL, V78, P377, DOI 10.1016/S0074-7742(06)78012-6
   HAMMEN C, 1991, J ABNORM PSYCHOL, V100, P555, DOI 10.1037/0021-843X.100.4.555
   HAYS AE, 2008, DISS ABSTR INT B, V68, P5779
   Holmes MK, 2008, BIPOLAR DISORD, V10, P806, DOI 10.1111/j.1399-5618.2008.00628.x
   Jago R, 2008, AM J PREV MED, V35, P554, DOI 10.1016/j.amepre.2008.07.007
   Johnson L, 2000, J AFFECT DISORDERS, V59, P139, DOI 10.1016/S0165-0327(99)00146-9
   Joosten EAG, 2008, PSYCHOTHER PSYCHOSOM, V77, P219, DOI 10.1159/000126073
   Kanazawa T, 2007, PSYCHIAT GENET, V17, P165, DOI 10.1097/YPG.0b013e32801da2e2
   Kapczinski F, 2009, BIPOLAR DISORD, V11, P221, DOI 10.1111/j.1399-5618.2008.00616.x
   Kapczinski Flavio, 2008, Expert Rev Neurother, V8, P1101, DOI 10.1586/14737175.8.7.1101
   Karege F, 2002, PSYCHIAT RES, V109, P143, DOI 10.1016/S0165-1781(02)00005-7
   KARPCZINSKI F, 2008, NEUROSCI BIOBEHAV R, V32, P675
   Kauer-Sant'Anna M, 2007, BIPOLAR DISORD, V9, P128, DOI 10.1111/j.1399-5618.2007.00478.x
   Keck PE, 2003, J CLIN PSYCHIAT, V64, P1426, DOI 10.4088/JCP.v64n1205
   Kilbourne AM, 2007, BIPOLAR DISORD, V9, P443, DOI 10.1111/j.1399-5618.2007.00386.x
   Leppämäki SJ, 2002, J CLIN PSYCHIAT, V63, P316, DOI 10.4088/JCP.v63n0408
   Licinio J, 2009, ARCH GEN PSYCHIAT, V66, P488, DOI 10.1001/archgenpsychiatry.2009.38
   Lin EHB, 2004, DIABETES CARE, V27, P2154, DOI 10.2337/diacare.27.9.2154
   Liu LS, 2007, CELL MOL NEUROBIOL, V27, P351, DOI 10.1007/s10571-006-9128-7
   Lu B, 2003, LEARN MEMORY, V10, P86, DOI 10.1101/lm.54603
   Lustman PJ, 2005, PSYCHOSOM MED, V67, P195, DOI 10.1097/01.psy.0000155670.88919.ad
   Lyoo IK, 2006, BIPOLAR DISORD, V8, P65, DOI 10.1111/j.1399-5618.2006.00284.x
   Ma Qiang, 2008, Neurosci Bull, V24, P265, DOI 10.1007/s12264-008-0402-1
   Machado-Vieira R, 2007, BIOL PSYCHIAT, V61, P142, DOI 10.1016/j.biopsych.2006.03.070
   Mackin P, 2007, AUST NZ J PSYCHIAT, V41, P321, DOI 10.1080/00048670701213211
   Majer M, 2004, PSYCHOL MED, V34, P1453, DOI 10.1017/S0033291704002697
   Manni L, 2005, INT J CARDIOL, V102, P169, DOI 10.1016/j.ijcard.2004.10.041
   McElroy SL, 2002, J CLIN PSYCHIAT, V63, P207, DOI 10.4088/JCP.v63n0306
   McEwen BS, 2003, BIOL PSYCHIAT, V54, P200, DOI 10.1016/S0006-3223(03)00177-X
   McEwen BS, 2004, ANN NY ACAD SCI, V1032, P1, DOI 10.1196/annals.1314.001
   McEwen BS, 1998, ANN NY ACAD SCI, V840, P33, DOI 10.1111/j.1749-6632.1998.tb09546.x
   Molteni R, 2009, NEUROPSYCHOPHARMACOL, V34, P1523, DOI 10.1038/npp.2008.208
   Monteleone P, 2008, BIPOLAR DISORD, V10, P95, DOI 10.1111/j.1399-5618.2008.00459.x
   Moore GJ, 2000, LANCET, V356, P1241, DOI 10.1016/S0140-6736(00)02793-8
   Moreira MM, 2008, ARQ BRAS CARDIOL, V91, P200
   Morriss Richard, 2005, J Psychopharmacol, V19, P94, DOI 10.1177/0269881105058678
   Nair A, 2007, NEUROPSYCHOPHARMACOL, V32, P1504, DOI 10.1038/sj.npp.1301276
   Nehra R, 2006, J AFFECT DISORDERS, V93, P185, DOI 10.1016/j.jad.2006.03.013
   Nestler EJ, 2002, NEURON, V34, P13, DOI 10.1016/S0896-6273(02)00653-0
   Ng F, 2007, J AFFECT DISORDERS, V101, P259, DOI 10.1016/j.jad.2006.11.014
   Otto MW, 2007, J CLIN PSYCHIAT, V68, P669, DOI 10.4088/JCP.v68n0515
   Paykel ES, 2003, ACTA PSYCHIAT SCAND, V108, P61, DOI 10.1034/j.1600-0447.108.s418.13.x
   Peh ALH, 2008, QUAL SAF HEALTH CARE, V17, P469, DOI 10.1136/qshc.2007.023481
   Pereira AC, 2007, P NATL ACAD SCI USA, V104, P5638, DOI 10.1073/pnas.0611721104
   Pierce RC, 2001, REV NEUROSCIENCE, V12, P95
   Post RM, 2007, J PSYCHIATR RES, V41, P979, DOI 10.1016/j.jpsychires.2006.09.009
   Poulin MJ, 2007, AUST NZ J PSYCHIAT, V41, P980, DOI 10.1080/00048670701689428
   Russo-Neustadt A, 2001, BEHAV BRAIN RES, V120, P87, DOI 10.1016/S0166-4328(00)00364-8
   Russo-Neustadt AA, 2000, NEUROSCIENCE, V101, P305, DOI 10.1016/S0306-4522(00)00349-3
   Rybakowski JK, 2007, AM J MED GENET B, V144B, P820, DOI 10.1002/ajmg.b.30420
   Rybakowski JK, 2008, PHARMACOGENOMICS, V9, P1589, DOI 10.2217/14622416.9.11.1589
   Rybakowski JK, 2005, PHARMACOPSYCHIATRY, V38, P166, DOI 10.1055/s-2005-871239
   Salvi V, 2008, J CLIN PSYCHIAT, V69, P1307, DOI 10.4088/JCP.v69n0816
   Salvi V, 2008, GEN HOSP PSYCHIAT, V30, P318, DOI 10.1016/j.genhosppsych.2008.04.009
   Scharfman H, 2005, EXP NEUROL, V192, P348, DOI 10.1016/j.expneurol.2004.11.016
   Scherk H, 2008, ACTA PSYCHIAT SCAND, V117, P283, DOI 10.1111/j.1600-0447.2007.01142.x
   Schinder AF, 2000, TRENDS NEUROSCI, V23, P639, DOI 10.1016/S0166-2236(00)01672-6
   Schumacher J, 2005, BIOL PSYCHIAT, V58, P307, DOI 10.1016/j.biopsych.2005.04.006
   Sen S, 2008, BIOL PSYCHIAT, V64, P527, DOI 10.1016/j.biopsych.2008.05.005
   Shimizu E, 2003, BIOL PSYCHIAT, V54, P70, DOI 10.1016/S0006-3223(03)00181-1
   Shirayama Y, 2002, J NEUROSCI, V22, P3251, DOI 10.1523/JNEUROSCI.22-08-03251.2002
   SMITH MA, 1995, J NEUROSCI, V15, P1768, DOI 10.1523/JNEUROSCI.15-03-01768.1995
   Stathopoulou G, 2006, CLIN PSYCHOL-SCI PR, V13, P179, DOI 10.1111/j.1468-2850.2006.00021.x
   Strakowski SM, 2002, AM J PSYCHIAT, V159, P1841, DOI 10.1176/appi.ajp.159.11.1841
   Ströhle A, 2007, PSYCHOL MED, V37, P1657, DOI 10.1017/S003329170700089X
   Sylvia LG, 2009, J PSYCHIATR PRACT, V15, P70, DOI 10.1097/01.pra.0000344923.81898.53
   Tang SW, 2008, NEUROSCI LETT, V431, P62, DOI 10.1016/j.neulet.2007.11.019
   Tapia-Arancibia L, 2008, BRAIN RES REV, V59, P201, DOI 10.1016/j.brainresrev.2008.07.007
   Tramontina JF, 2009, NEUROSCI LETT, V452, P111, DOI 10.1016/j.neulet.2009.01.028
   Tsatsoulis A, 2006, ANN NY ACAD SCI, V1083, P196, DOI 10.1196/annals.1367.020
   Tseng M, 2008, J PSYCHIATR NEUROSCI, V33, P449
   Tsuchida A, 2002, DIABETES OBES METAB, V4, P262, DOI 10.1046/j.1463-1326.2002.00206.x
   van Praag H, 2005, J NEUROSCI, V25, P8680, DOI 10.1523/JNEUROSCI.1731-05.2005
   Vaynman S, 2003, NEUROSCIENCE, V122, P647, DOI 10.1016/j.neuroscience.2003.08.001
   Vega SR, 2006, BRAIN RES, V1121, P59, DOI 10.1016/j.brainres.2006.08.105
   Velakoulis D, 2006, ARCH GEN PSYCHIAT, V63, P139, DOI 10.1001/archpsyc.63.2.139
   Waxmonsky JA, 2005, GEN HOSP PSYCHIAT, V27, P321, DOI 10.1016/j.genhosppsych.2005.05.003
   Weiss SJ, 2007, PERSPECT PSYCHIATR C, V43, P114, DOI 10.1111/j.1744-6163.2007.00120.x
   Wingo AP, 2009, BIPOLAR DISORD, V11, P113, DOI 10.1111/j.1399-5618.2009.00665.x
   Yamanaka M, 2008, J BIOSCI BIOENG, V105, P395, DOI 10.1263/jbb.105.395
   Yamasue H, 2004, PSYCHIAT RES-NEUROIM, V131, P195, DOI 10.1016/j.pscychresns.2004.05.004
   Yatham LN, 2007, BIPOLAR DISORD, V9, P693, DOI 10.1111/j.1399-5618.2007.00414.x
   Zhao CM, 2008, CELL, V132, P645, DOI 10.1016/j.cell.2008.01.033
NR 124
TC 48
Z9 49
U1 0
U2 30
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0033-3190
EI 1423-0348
J9 PSYCHOTHER PSYCHOSOM
JI Psychother. Psychosom.
PY 2010
VL 79
IS 2
BP 87
EP 96
DI 10.1159/000270916
PG 10
WC Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 555PW
UT WOS:000274526600003
PM 20051706
DA 2025-06-11
ER

PT J
AU Gambino, G
   Giglia, G
   Allegra, M
   Di Liberto, V
   Zummo, FP
   Rappa, F
   Restivo, I
   Vetrano, F
   Saiano, F
   Palazzolo, E
   Avellone, G
   Ferraro, G
   Sardo, P
   Di Majo, D
AF Gambino, Giuditta
   Giglia, Giuseppe
   Allegra, Mario
   Di Liberto, Valentina
   Zummo, Francesco Paolo
   Rappa, Francesca
   Restivo, Ignazio
   Vetrano, Filippo
   Saiano, Filippo
   Palazzolo, Eristanna
   Avellone, Giuseppe
   Ferraro, Giuseppe
   Sardo, Pierangelo
   Di Majo, Danila
TI "Golden" Tomato Consumption Ameliorates Metabolic Syndrome: A Focus on
   the Redox Balance in the High-Fat-Diet-Fed Rat
SO ANTIOXIDANTS
LA English
DT Article
DE tomato-based products; metabolic syndrome; HFD; antioxidant capacity;
   phytonutrients
ID OXIDATIVE STRESS LEVELS; SUPPLEMENTATION; NARINGENIN; LIVER; RISK;
   DEFINITION; EXPRESSION; MICROBIOTA; OBESITY; LIPIDS
AB Tomato fruits defined as "golden" refer to a food product harvested at an incomplete ripening stage with respect to red tomatoes at full maturation. The aim of this study is to explore the putative influence of "golden tomato" (GT) on Metabolic Syndrome (MetS), especially focusing on the effects on redox homeostasis. Firstly, the differential chemical properties of the GT food matrix were characterized in terms of phytonutrient composition and antioxidant capacities with respect to red tomato (RT). Later, we assessed the biochemical, nutraceutical and eventually disease-modifying potential of GT in vivo in the high-fat-diet rat model of MetS. Our data revealed that GT oral supplementation is able to counterbalance MetS-induced biometric and metabolic modifications. Noteworthy is that this nutritional supplementation proved to reduce plasma oxidant status and improve the endogenous antioxidant barriers, assessed by strong systemic biomarkers. Furthermore, consistently with the reduction of hepatic reactive oxygen and nitrogen species (RONS) levels, treatment with GT markedly reduced the HFD-induced increase in hepatic lipid peroxidation and hepatic steatosis. This research elucidates the importance of food supplementation with GT in the prevention and management of MetS.
C1 [Gambino, Giuditta; Giglia, Giuseppe; Di Liberto, Valentina; Zummo, Francesco Paolo; Rappa, Francesca; Ferraro, Giuseppe; Sardo, Pierangelo; Di Majo, Danila] Univ Palermo, Dept Biomed Neurosci & Adv Diagnost BIND, I-90127 Palermo, Italy.
   [Giglia, Giuseppe] Euro Mediterranean Inst Sci & Technol IEMEST, I-90139 Palermo, Italy.
   [Allegra, Mario; Ferraro, Giuseppe; Sardo, Pierangelo; Di Majo, Danila] Univ Palermo, Postgrad Sch Nutr & Food Sci, I-90100 Palermo, Italy.
   [Allegra, Mario; Restivo, Ignazio; Avellone, Giuseppe] Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol STEBICEF, Viale Sci, I-90128 Palermo, Italy.
   [Vetrano, Filippo; Saiano, Filippo; Palazzolo, Eristanna] Univ Palermo, Dipartimento Sci Agrarie Alimentari & Forestali, Viale Sci Ed4, I-90128 Palermo, Italy.
   [Avellone, Giuseppe] ATeN Adv Technol Network Ctr, Viale Sci, I-90128 Palermo, Italy.
C3 University of Palermo; University of Palermo; University of Palermo;
   University of Palermo
RP Gambino, G (corresponding author), Univ Palermo, Dept Biomed Neurosci & Adv Diagnost BIND, I-90127 Palermo, Italy.
EM giuditta.gambino@unipa.it; giuseppe.giglia@unipa.it;
   mario.allegra@unipa.it; valentina.diliberto@unipa.it;
   francescopaolo.zummo@unipa.it; francesca.rappa@unipa.it;
   filippo.vetrano@unipa.it; filippo.saiano@unipa.it;
   eristanna.palazzolo@unipa.it; giuseppe.avellone@unipa.it;
   giuseppe.ferraro@unipa.it; pierangelo.sardo@unipa.it;
   danila.dimajo@unipa.it
RI Restivo, Ignazio/AAW-8282-2020; Francesca, Rappa/ADW-8431-2022;
   Avellone, Giuseppe/Q-2826-2016; Di Majo, Danila/A-9078-2015; Di+Liberto,
   Valentina/ACL-0264-2022; Zummo, Francesco Paolo/HME-2405-2023; Allegra,
   Mario/AAG-3256-2019; Giglia, Giuseppe/M-7100-2016
OI DI MAJO, Danila/0000-0002-0533-6932; Gambino,
   Giuditta/0000-0001-8155-2808; rappa, francesca/0000-0001-6610-5268;
   Saiano, Filippo/0000-0001-6873-3698; RESTIVO,
   IGNAZIO/0000-0003-1833-2356; Zummo, Francesco Paolo/0000-0001-9872-8574;
   Di Liberto, Valentina/0000-0002-8574-0061; Allegra,
   Mario/0000-0002-5846-1868; Giglia, Giuseppe/0000-0001-5616-3595
FU PSR Sicilia [G66D20000170009]; University of Palermo
FX This work was partly supported by the project IN.PO.S.A-Grant Number:
   G66D20000170009, funded by PSR Sicilia (2014-2020)-16.1 and partly with
   FFR Funds provided by University of Palermo to Danila Di Majo and
   Giuditta Gambino.
CR Aborehab NM, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1203-0
   Alam MA, 2014, ADV NUTR, V5, P404, DOI 10.3945/an.113.005603
   Alam P, 2019, J HERB MED, V16, DOI 10.1016/j.hermed.2018.09.006
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Ali MY, 2021, FOODS, V10, DOI 10.3390/foods10010045
   Allegra M, 2002, J PINEAL RES, V32, P187, DOI 10.1034/j.1600-079x.2002.1o852.x
   Andrade-Pavón D, 2022, INDIAN J MICROBIOL, V62, P79, DOI 10.1007/s12088-021-00980-0
   Araújo MC, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11081292
   Auberval N, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-130
   Benzie IFF, 1999, METHOD ENZYMOL, V299, P15
   Blum A, 2006, CLIN INVEST MED, V29, P298
   Bose KSC, 2006, W INDIAN MED J, V55, P274
   Bowe JE, 2014, J ENDOCRINOL, V222, pG13, DOI 10.1530/JOE-14-0182
   Cheng HM, 2017, ATHEROSCLEROSIS, V257, P100, DOI 10.1016/j.atherosclerosis.2017.01.009
   Cho AS, 2010, FOOD CHEM TOXICOL, V48, P937, DOI 10.1016/j.fct.2010.01.003
   Cruz-Carrin A, 2021, FOOD FUNCT, V12, P8340, DOI [10.1039/D1FO00955A, 10.1039/d1fo00955a]
   Cuevas-Ramos D, 2013, DIABET METAB SYND OB, V6, P263, DOI 10.2147/DMSO.S48858
   Dabke K, 2019, J CLIN INVEST, V129, P4050, DOI 10.1172/JCI129194
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   DeVallance E, 2019, ANTIOXID REDOX SIGN, V31, P687, DOI 10.1089/ars.2018.7674
   Di Majo D, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12010089
   Di Majo D, 2022, NUTRIENTS, V14, DOI 10.3390/nu14122384
   Di Majo D, 2011, J FOOD COMPOS ANAL, V24, P265, DOI 10.1016/j.jfca.2010.09.013
   Gambino G, 2022, NUTRIENTS, V14, DOI 10.3390/nu14224915
   Gambino G, 2022, FREE RADICAL BIO MED, V191, P128, DOI 10.1016/j.freeradbiomed.2022.08.025
   Gambino G, 2020, BRAIN SCI, V10, DOI 10.3390/brainsci10120908
   Giammanco M, 2018, J BIOL RES-BOLL SOC, V91, P108, DOI 10.4081/jbr.2018.7755
   Giammanco M, 2016, J BIOL RES-BOLL SOC, V89, P4, DOI 10.4081/jbr.2016.5667
   Giuditta G, 2020, BRAIN STRUCT FUNCT, V225, P1, DOI 10.1007/s00429-019-01992-9
   Gulcin I, 2020, ARCH TOXICOL, V94, P651, DOI 10.1007/s00204-020-02689-3
   Holzer P, 2014, BRIT J PHARMACOL, V171, P2469, DOI 10.1111/bph.12723
   Huang K, 2015, J SCI FOOD AGR, V95, P1903, DOI 10.1002/jsfa.6896
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Elvira-Torales LI, 2018, NUTRIENTS, V10, DOI 10.3390/nu10091215
   Islam N., 2017, Anwer Khan Mod. Med. Coll. J, V8, P30, DOI [10.3329/akmmcj.v8i1.31655, DOI 10.3329/AKMMCJ.V8I1.31655]
   Jansen E, 2015, INT J MOL SCI, V16, P27378, DOI 10.3390/ijms161126032
   Jin SS, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0120842
   Kakimoto PA, 2016, REDOX BIOL, V8, P216, DOI 10.1016/j.redox.2016.01.009
   Kim B, 2015, EXP MOL MED, V47, DOI 10.1038/emm.2015.3
   Lee MK, 2003, BIOORGAN MED CHEM, V11, P393, DOI 10.1016/S0968-0896(02)00441-8
   Lee S, 2017, FREE RADICAL RES, V51, P179, DOI 10.1080/10715762.2017.1291939
   Li H, 2020, PHYTOTHER RES, V34, P1956, DOI 10.1002/ptr.6660
   Li JD, 2021, FOOD FUNCT, V12, P3898, DOI [10.1039/d0fo02736g, 10.1039/D0FO02736G]
   Li N, 2021, FOOD CHEM, V343, DOI 10.1016/j.foodchem.2020.128396
   Li P, 2021, MOL NUTR FOOD RES, V65, DOI 10.1002/mnfr.202100007
   Li S, 2019, NUTR DIABETES, V9, DOI 10.1038/s41387-019-0095-8
   Ma YJ, 2015, PHARM RES-DORDR, V32, P1200, DOI 10.1007/s11095-014-1526-9
   Macri A, 2015, GRAEF ARCH CLIN EXP, V253, P425, DOI 10.1007/s00417-014-2853-6
   Mancini S, 2017, REDOX REP, V22, P399, DOI 10.1080/13510002.2016.1277049
   MCGUIRE RG, 1992, HORTSCIENCE, V27, P1254, DOI 10.21273/HORTSCI.27.12.1254
   McKeegan K, 2021, REDOX BIOL, V44, DOI 10.1016/j.redox.2021.102005
   Moncada A, 2022, AGRONOMY-BASEL, V12, DOI 10.3390/agronomy12020329
   Nouri MHK, 2013, IRAN RED CRESCENT ME, V15, P287, DOI 10.5812/ircmj.1007
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   Palermo A, 2011, EXP BRAIN RES, V212, P101, DOI 10.1007/s00221-011-2701-4
   Paolisso G, 1996, J CLIN ENDOCR METAB, V81, P4244, DOI 10.1210/jc.81.12.4244
   Phachonpai W., 2013, Online Journal of Biological Sciences, V13, P28
   Reagan-Shaw S, 2008, FASEB J, V22, P659, DOI 10.1096/fj.07-9574LSF
   Rodríguez-Correa E, 2020, NUTR DIABETES, V10, DOI 10.1038/s41387-020-0127-4
   Santana-Gálvez J, 2017, MOLECULES, V22, DOI 10.3390/molecules22030358
   Spahis S, 2017, ANTIOXID REDOX SIGN, V26, P445, DOI 10.1089/ars.2016.6756
   Spooner HC, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124195
   Terzo S, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11010080
   Thies F, 2012, AM J CLIN NUTR, V95, P1013, DOI 10.3945/ajcn.111.026286
   Ferron AJT, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8090368
   Tomasello G., 2015, EUROMEDITERRANEAN BI, V10), P65, DOI [10.3269/1970-5492.2015.10.1, DOI 10.3269/1970-5492.2015.10.1]
   Tralongo Pietro., 2014, Euromediterranean Biomedical Journal, V9, P24
   Vatashchuk MV, 2022, BIOMED RES INT, V2022, DOI 10.1155/2022/5850507
   Wan CW, 2013, PHYTOTHER RES, V27, P545, DOI 10.1002/ptr.4751
   Wang PX, 2020, CHINESE MED J-PEKING, V133, P808, DOI 10.1097/CM9.0000000000000696
   Willcox JK, 2003, CRIT REV FOOD SCI, V43, P1, DOI 10.1080/10408690390826437
   Zhao MJ, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201801417
   Zygmunt K, 2010, BIOCHEM BIOPH RES CO, V398, P178, DOI 10.1016/j.bbrc.2010.06.048
NR 73
TC 6
Z9 6
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAY 18
PY 2023
VL 12
IS 5
AR 1121
DI 10.3390/antiox12051121
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA H2ZW5
UT WOS:000994711100001
PM 37237987
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kushiyama, A
   Nakatsu, Y
   Matsunaga, Y
   Yamamotoya, T
   Mori, K
   Ueda, K
   Inoue, Y
   Sakoda, H
   Fujishiro, M
   Ono, H
   Asano, T
AF Kushiyama, Akifumi
   Nakatsu, Yusuke
   Matsunaga, Yasuka
   Yamamotoya, Takeshi
   Mori, Keiichi
   Ueda, Koji
   Inoue, Yuki
   Sakoda, Hideyuki
   Fujishiro, Midori
   Ono, Hiraku
   Asano, Tomoichiro
TI Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of
   Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic
   Steatohepatitis
SO MEDIATORS OF INFLAMMATION
LA English
DT Review
ID FATTY LIVER-DISEASE; IMPROVES ENDOTHELIAL FUNCTION; XANTHINE-OXIDASE
   INHIBITION; MUSCLE-CELL-PROLIFERATION; HIGH-DOSE ALLOPURINOL; OXIDATIVE
   STRESS; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; ESSENTIAL-HYPERTENSION;
   ISCHEMIA-REPERFUSION
AB Uric acid (UA) is the end product of purine metabolism and can reportedly act as an antioxidant. However, recently, numerous clinical and basic research approaches have revealed close associations of hyperuricemia with several disorders, particularly those comprising the metabolic syndrome. In this review, we first outline the two molecular mechanisms underlying inflammation occurrence in relation to UA metabolism; one is inflammasome activation by UA crystallization and the other involves superoxide free radicals generated by xanthine oxidase (XO). Importantly, recent studies have demonstrated the therapeutic or preventive effects of XO inhibitors against atherosclerosis and nonalcoholic steatohepatitis, which were not previously considered to be related, at least not directly, to hyperuricemia. Such beneficial effects of XO inhibitors have been reported for other organs including the kidneys and the heart. Thus, a major portion of this review focuses on the relationships between UA metabolism and the development of atherosclerosis, nonalcoholic steatohepatitis, and related disorders. Although further studies are necessary, XO inhibitors are a potentially novel strategy for reducing the risk of many forms of organ failure characteristic of the metabolic syndrome.
C1 [Kushiyama, Akifumi] Asahi Life Fdn, Inst Adult Dis, Div Diabet & Metab, Chiyoda Ku, 1-6-1 Marunouchi, Tokyo, Japan.
   [Nakatsu, Yusuke; Matsunaga, Yasuka; Yamamotoya, Takeshi; Mori, Keiichi; Ueda, Koji; Inoue, Yuki; Asano, Tomoichiro] Hiroshima Univ, Grad Sch Med, Dept Med Sci, Minami Ku, 1-2-3 Kasumi, Hiroshima, Hiroshima, Japan.
   [Sakoda, Hideyuki] Miyazaki Univ, Dept Internal Med, Fac Med, Div Neurol Respirol Endocrinol & Metab, Miyazaki 8891692, Japan.
   [Fujishiro, Midori] Univ Tokyo, Grad Sch Med, Dept Internal Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo, Japan.
   [Ono, Hiraku] Saitama Med Univ, Sch Med, Dept Endocrinol & Diabet, Moroyama, Saitama 3500495, Japan.
C3 Asahi Life Foundation; Hiroshima University; University of Miyazaki;
   University of Tokyo; Saitama Medical University
RP Kushiyama, A (corresponding author), Asahi Life Fdn, Inst Adult Dis, Div Diabet & Metab, Chiyoda Ku, 1-6-1 Marunouchi, Tokyo, Japan.
EM kusiyaa-tky@umin.ac.jp
RI 祐介, 中津/AAP-8396-2020; Kushiyama, Akifumi/W-5988-2019
OI Nakatsu, Yusuke/0000-0003-3279-1276; Kushiyama,
   Akifumi/0000-0003-1385-7487
FU Grants-in-Aid for Scientific Research [15K09398, 16J09463] Funding
   Source: KAKEN
CR Agarwal V, 2013, J CLIN HYPERTENS, V15, P435, DOI 10.1111/j.1751-7176.2012.00701.x
   Alderman MH, 1999, HYPERTENSION, V34, P144, DOI 10.1161/01.HYP.34.1.144
   Aliciguzel Y, 2003, J LAB CLIN MED, V142, P172, DOI 10.1016/S0022-2143(03)00110-0
   AMES BN, 1981, P NATL ACAD SCI-BIOL, V78, P6858, DOI 10.1073/pnas.78.11.6858
   Aranda R, 2007, FREE RADICAL RES, V41, P1195, DOI 10.1080/10715760701481461
   Asai R, 2007, J BIOCHEM, V141, P525, DOI 10.1093/jb/mvm054
   Ashtari F, 2013, J CLIN NEUROSCI, V20, P676, DOI 10.1016/j.jocn.2012.05.054
   Baldwin W, 2011, DIABETES, V60, P1258, DOI 10.2337/db10-0916
   BARBER MJ, 1977, BIOCHEM J, V163, P279, DOI 10.1042/bj1630279
   Bashiri A, 2016, BBA-MOL CELL BIOL L, V1861, P594, DOI 10.1016/j.bbalip.2016.04.005
   Berry CE, 2004, J PHYSIOL-LONDON, V555, P589, DOI 10.1113/jphysiol.2003.055913
   Bhole V, 2010, AM J MED, V123, P957, DOI 10.1016/j.amjmed.2010.03.027
   Biri H, 1999, CANCER INVEST, V17, P314, DOI 10.3109/07357909909032872
   Bos MJ, 2006, STROKE, V37, P1503, DOI 10.1161/01.STR.0000221716.55088.d4
   Browning JD, 2004, J CLIN INVEST, V114, P147, DOI 10.1172/JCI200422422
   Cai H, 2000, CIRC RES, V87, P840, DOI 10.1161/01.RES.87.10.840
   Chen GL, 2014, INDIAN J EXP BIOL, V52, P597
   Choi HK, 2007, CIRCULATION, V116, P894, DOI 10.1161/CIRCULATIONAHA.107.703389
   Choi YJ, 2014, LAB INVEST, V94, P1114, DOI 10.1038/labinvest.2014.98
   Choi YJ, 2014, FASEB J, V28, P3197, DOI 10.1096/fj.13-247148
   Cicerchi C, 2014, FASEB J, V28, P3339, DOI 10.1096/fj.13-243634
   Corry DB, 2008, J HYPERTENS, V26, P269, DOI 10.1097/HJH.0b013e3282f240bf
   Csak T, 2011, HEPATOLOGY, V54, P133, DOI 10.1002/hep.24341
   Davies NS, 1897, JAMA, V29, P261, DOI DOI 10.1001/JAMA.1897.02440320005001A
   Davis JW, 1996, AM J EPIDEMIOL, V144, P480, DOI 10.1093/oxfordjournals.aje.a008954
   de Jong JW, 2000, J MOL CELL CARDIOL, V32, P2083, DOI 10.1006/jmcc.2000.1240
   Dixon LJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0056100
   Drulovic J, 2001, J NEUROL, V248, P121, DOI 10.1007/s004150170246
   Duda M, 2007, J MOL CELL CARDIOL, V42, P400, DOI 10.1016/j.yjmcc.2006.10.014
   Duewell P, 2010, NATURE, V464, P1357, DOI 10.1038/nature08938
   Elmas O, 2011, RENAL FAILURE, V33, P61, DOI 10.3109/0886022X.2010.536606
   Fabbrini E, 2014, DIABETES, V63, P976, DOI 10.2337/db13-1396
   FACCHINI F, 1991, JAMA-J AM MED ASSOC, V266, P3008, DOI 10.1001/jama.266.21.3008
   Farrell GC, 2006, HEPATOLOGY, V43, pS99, DOI 10.1002/hep.20973
   Farrell GC, 2012, GUT LIVER, V6, P149, DOI 10.5009/gnl.2012.6.2.149
   Feig DI, 2008, NEW ENGL J MED, V359, P1811, DOI 10.1056/NEJMra0800885
   Feig DI, 2008, JAMA-J AM MED ASSOC, V300, P924, DOI 10.1001/jama.300.8.924
   Feig DI, 2003, HYPERTENSION, V42, P247, DOI 10.1161/01.HYP.0000085858.66548.59
   Förstermann U, 2010, PFLUG ARCH EUR J PHY, V459, P923, DOI 10.1007/s00424-010-0808-2
   Ford ES, 2007, CIRCULATION, V115, P2526, DOI 10.1161/CIRCULATIONAHA.106.657627
   Forman JP, 2009, ARCH INTERN MED, V169, P155, DOI 10.1001/archinternmed.2008.521
   Gabrielli LA, 2011, J CARD FAIL, V17, P1012, DOI 10.1016/j.cardfail.2011.08.008
   Gasse P, 2009, AM J RESP CRIT CARE, V179, P903, DOI 10.1164/rccm.200808-1274OC
   George J, 2006, CIRCULATION, V114, P2508, DOI 10.1161/CIRCULATIONAHA.106.651117
   Gersch C, 2008, NUCLEOS NUCLEOT NUCL, V27, P967, DOI 10.1080/15257770802257952
   Gibbings S, 2011, J BIOL CHEM, V286, P961, DOI 10.1074/jbc.M110.150847
   Grimaldi-Bensouda L, 2015, ANN RHEUM DIS, V74, P836, DOI 10.1136/annrheumdis-2012-202972
   HALLFRISCH J, 1990, FASEB J, V4, P2652, DOI 10.1096/fasebj.4.9.2189777
   Hartney T, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027531
   Henao-Mejia J, 2012, NATURE, V482, P179, DOI 10.1038/nature10809
   Herrera EA, 2012, J PHYSIOL-LONDON, V590, P1825, DOI 10.1113/jphysiol.2011.224576
   Hossain MF, 2015, N AM J MED SCI, V7, P253, DOI 10.4103/1947-2714.159329
   HUNT SC, 1991, HYPERTENSION, V17, P969, DOI 10.1161/01.HYP.17.6.969
   Jankov RP, 2008, AM J PHYSIOL-LUNG C, V294, pL233, DOI 10.1152/ajplung.00166.2007
   Jhang JJ, 2015, CELL MOL IMMUNOL, V12, P424, DOI 10.1038/cmi.2014.65
   Jia ZT, 2013, DIABETES RES CLIN PR, V101, P88, DOI 10.1016/j.diabres.2013.03.026
   Kamogawa E, 2014, BIOORG MED CHEM LETT, V24, P1376, DOI 10.1016/j.bmcl.2014.01.045
   Kane AD, 2014, J PHYSIOL-LONDON, V592, P475, DOI 10.1113/jphysiol.2013.264275
   Kato S, 2016, NAGOYA J MED SCI, V78, P135
   Keenan T, 2012, AM J CARDIOL, V110, P1787, DOI 10.1016/j.amjcard.2012.08.012
   Keizman D, 2009, J NEUROL SCI, V285, P95, DOI 10.1016/j.jns.2009.06.002
   Khosla UM, 2005, KIDNEY INT, V67, P1739, DOI 10.1111/j.1523-1755.2005.00273.x
   Kishimoto K, 2015, LEUKEMIA LYMPHOMA, V56, P2193, DOI 10.3109/10428194.2014.991923
   Klein BEK, 2002, DIABETES CARE, V25, P1790, DOI 10.2337/diacare.25.10.1790
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Kodama S, 2009, DIABETES CARE, V32, P1737, DOI 10.2337/dc09-0288
   Kosugi T, 2009, AM J PHYSIOL-RENAL, V297, pF481, DOI 10.1152/ajprenal.00092.2009
   Krishnan E, 2007, HYPERTENSION, V49, P298, DOI 10.1161/01.HYP.0000254480.64564.b6
   Kumar A, 2014, J CLIN DIAGN RES, V8, pHC3, DOI 10.7860/JCDR/2014/9638.5255
   Kushiyama A, 2012, ARTERIOSCL THROM VAS, V32, P291, DOI 10.1161/ATVBAHA.111.234559
   Lanaspa MA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048801
   Lanaspa MA, 2012, J BIOL CHEM, V287, P40732, DOI 10.1074/jbc.M112.399899
   Lanaspa MA, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0047948, 10.1371/journal.pone.0048801]
   Landmesser U, 2007, ARTERIOSCL THROM VAS, V27, P943, DOI 10.1161/01.ATV.0000258415.32883.bf
   Lee HJ, 2014, AM J NEPHROL, V40, P56, DOI 10.1159/000363421
   Lee JW, 2010, GUT LIVER, V4, P378, DOI 10.5009/gnl.2010.4.3.378
   Lerret SM, 2011, GASTROENTEROL NURS, V34, P434, DOI 10.1097/SGA.0b013e3182371356
   Li HG, 2013, TRENDS PHARMACOL SCI, V34, P313, DOI 10.1016/j.tips.2013.03.007
   Li M, 2016, SCI REP-UK, V6, DOI 10.1038/srep19520
   Li YM, 2009, J HEPATOL, V50, P1029, DOI 10.1016/j.jhep.2008.11.021
   Lim JS, 2010, NAT REV GASTRO HEPAT, V7, P251, DOI 10.1038/nrgastro.2010.41
   Liu B, 2012, NEUROL RES, V34, P163, DOI 10.1179/1743132811Y.0000000074
   Loomba R, 2013, NAT REV GASTRO HEPAT, V10, P686, DOI 10.1038/nrgastro.2013.171
   Lv Q, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0056864
   Malardé L, 2014, MOL CELL BIOCHEM, V389, P113, DOI 10.1007/s11010-013-1932-z
   Martin HM, 2004, FREE RADICAL BIO MED, V37, P1214, DOI 10.1016/j.freeradbiomed.2004.06.045
   Martinon F, 2006, NATURE, V440, P237, DOI 10.1038/nature04516
   Martinon F, 2002, MOL CELL, V10, P417, DOI 10.1016/S1097-2765(02)00599-3
   Matsuzaka T, 2012, HEPATOLOGY, V56, P2199, DOI 10.1002/hep.25932
   Matteoni CA, 1999, GASTROENTEROLOGY, V116, P1413, DOI 10.1016/S0016-5085(99)70506-8
   Mazzali M, 2001, HYPERTENSION, V38, P1101, DOI 10.1161/hy1101.092839
   Mazzali M, 2002, AM J PHYSIOL-RENAL, V282, pF991, DOI 10.1152/ajprenal.00283.2001
   Medvedeva NB, 2008, B EXP BIOL MED+, V146, P203, DOI 10.1007/s10517-008-0251-y
   Medzhitov R, 2008, NATURE, V454, P428, DOI 10.1038/nature07201
   Mills KHG, 2013, J LEUKOCYTE BIOL, V93, P489, DOI 10.1189/jlb.1012543
   Mishima M, 2016, DRUG RES, V66, P270, DOI 10.1055/s-0035-1569405
   Mittal A, 2008, WORLD J SURG, V32, P288, DOI 10.1007/s00268-007-9336-4
   Mittal S, 2013, J CLIN GASTROENTEROL, V47, pS2, DOI 10.1097/MCG.0b013e3182872f29
   Miura K, 2013, HEPATOLOGY, V57, P577, DOI 10.1002/hep.26081
   Moore KJ, 2013, NAT REV IMMUNOL, V13, P709, DOI 10.1038/nri3520
   MORIWAKI Y, 1993, BIOCHIM BIOPHYS ACTA, V1164, P327, DOI 10.1016/0167-4838(93)90266-T
   Morse E, 2010, AM J PHYSIOL-RENAL, V299, pF965, DOI 10.1152/ajprenal.00236.2010
   Nakatsu Y, 2015, AM J PHYSIOL-GASTR L, V309, pG42, DOI 10.1152/ajpgi.00443.2014
   Nicholas SA, 2011, CELL MOL LIFE SCI, V68, P151, DOI 10.1007/s00018-010-0450-3
   Noman A, 2010, LANCET, V375, P2161, DOI 10.1016/S0140-6736(10)60391-1
   Nomura J, 2015, J IMMUNOL, V195, P5718, DOI 10.4049/jimmunol.1402512
   Nomura J, 2014, SCI REP-UK, V4, DOI 10.1038/srep04554
   Nomura J, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0075527
   Ogino K, 2010, CIRC-HEART FAIL, V3, P73, DOI 10.1161/CIRCHEARTFAILURE.109.868604
   OHARA Y, 1993, J CLIN INVEST, V91, P2546, DOI 10.1172/JCI116491
   Ohtsubo T, 2004, CIRC RES, V95, P1118, DOI 10.1161/01.RES.0000149571.96304.36
   Ohtsubo T, 2009, HYPERTENSION, V54, P868, DOI 10.1161/HYPERTENSIONAHA.109.135152
   Omori H, 2012, CLIN EXP NEPHROL, V16, P549, DOI 10.1007/s10157-012-0609-3
   Ono T, 2009, BRAIN RES, V1305, P158, DOI 10.1016/j.brainres.2009.09.061
   Paganoni S, 2012, J NEUROL, V259, P1923, DOI 10.1007/s00415-012-6440-7
   Papi A, 2008, J BIOL CHEM, V283, P28595, DOI 10.1074/jbc.M805766200
   PATT A, 1988, J CLIN INVEST, V81, P1556, DOI 10.1172/JCI113488
   Patterson RA, 2003, J LIPID RES, V44, P512, DOI 10.1194/jlr.M200407-JLR200
   Peglow S, 2011, J HEPATO-BIL-PAN SCI, V18, P137, DOI 10.1007/s00534-010-0328-7
   Perez-Pozo SE, 2010, INT J OBESITY, V34, P454, DOI 10.1038/ijo.2009.259
   Perlstein TS, 2006, HYPERTENSION, V48, P1031, DOI 10.1161/01.HYP.0000248752.08807.4c
   PETERSON DA, 1985, BIOCHEM BIOPH RES CO, V127, P87, DOI 10.1016/S0006-291X(85)80129-7
   Petrilli V, 2007, CELL DEATH DIFFER, V14, P1583, DOI 10.1038/sj.cdd.4402195
   Petta S, 2011, ALIMENT PHARM THER, V34, P757, DOI 10.1111/j.1365-2036.2011.04788.x
   Pfister R, 2011, DIABETOLOGIA, V54, P2561, DOI 10.1007/s00125-011-2235-0
   Portugal-Cohen M, 2009, J DERMATOL SCI, V55, P82, DOI 10.1016/j.jdermsci.2009.05.006
   Pritsos CA, 2000, CHEM-BIOL INTERACT, V129, P195, DOI 10.1016/S0009-2797(00)00203-9
   León-Carmona JR, 2011, J PHYS CHEM B, V115, P15430, DOI 10.1021/jp209776x
   Rajendra NS, 2011, J AM COLL CARDIOL, V58, P820, DOI 10.1016/j.jacc.2010.12.052
   RAO GN, 1991, J BIOL CHEM, V266, P8604
   Rathmann W, 1998, ANN EPIDEMIOL, V8, P250, DOI 10.1016/S1047-2797(97)00204-4
   Razani B, 2012, CELL METAB, V15, P534, DOI 10.1016/j.cmet.2012.02.011
   Rock KL, 2013, NAT REV RHEUMATOL, V9, P13, DOI 10.1038/nrrheum.2012.143
   ROE TF, 1977, PEDIATR RES, V11, P664, DOI 10.1203/00006450-197705000-00008
   Ryu ES, 2013, AM J PHYSIOL-RENAL, V304, pF471, DOI 10.1152/ajprenal.00560.2012
   Sachdev S, 2008, FREE RADICAL BIO MED, V44, P215, DOI 10.1016/j.freeradbiomed.2007.07.019
   Sánchez-Lozada LG, 2008, NEPHRON PHYSIOL, V108, P69, DOI 10.1159/000127837
   Sánchez-Lozada LG, 2008, AM J PHYSIOL-RENAL, V294, pF710, DOI 10.1152/ajprenal.00454.2007
   Santos CXC, 1999, ARCH BIOCHEM BIOPHYS, V372, P285, DOI 10.1006/abbi.1999.1491
   Sautin YY, 2007, AM J PHYSIOL-CELL PH, V293, pC584, DOI 10.1152/ajpcell.00600.2006
   Schroder K, 2010, CELL, V140, P821, DOI 10.1016/j.cell.2010.01.040
   Schroder K, 2010, SCIENCE, V327, P296, DOI 10.1126/science.1184003
   Schröder K, 2006, FREE RADICAL BIO MED, V41, P1353, DOI 10.1016/j.freeradbiomed.2006.03.026
   SELBY JV, 1990, AM J EPIDEMIOL, V131, P1017, DOI 10.1093/oxfordjournals.aje.a115593
   Sertoglu E, 2014, CLIN BIOCHEM, V47, P383, DOI 10.1016/j.clinbiochem.2014.01.029
   Shafik AN, 2013, DIGEST DIS SCI, V58, P650, DOI 10.1007/s10620-012-2391-1
   Sluijs I, 2015, DIABETES, V64, P3028, DOI 10.2337/db14-0742
   Soletsky B, 2012, HYPERTENSION, V60, P1148, DOI 10.1161/HYPERTENSIONAHA.112.196980
   Soucy KG, 2010, J APPL PHYSIOL, V108, P1250, DOI 10.1152/japplphysiol.00946.2009
   Spiekermann S, 2003, CIRCULATION, V107, P1383, DOI 10.1161/01.CIR.0000056762.69302.46
   Stack AG, 2013, QJM-INT J MED, V106, P647, DOI 10.1093/qjmed/hct083
   STIRPE F, 1970, LANCET, V2, P1310
   Sundström J, 2005, HYPERTENSION, V45, P28, DOI 10.1161/01.HYP.0000150784.92944.9a
   Taha MO, 2009, TRANSPL P, V41, P820, DOI 10.1016/j.transproceed.2009.02.051
   Tanaka K, 2015, CLIN EXP NEPHROL, V19, P1044, DOI 10.1007/s10157-015-1095-1
   Tanaka K, 2015, J DIABETES INVEST, V6, P98, DOI 10.1111/jdi.12243
   Tanaka K, 2011, CLIN EXP NEPHROL, V15, P391, DOI 10.1007/s10157-011-0420-6
   Toncev G, 2002, EUR J NEUROL, V9, P221, DOI 10.1046/j.1468-1331.2002.00384.x
   Tsuda H, 2012, BIOCHEM BIOPH RES CO, V427, P266, DOI 10.1016/j.bbrc.2012.09.032
   Tsushima Y, 2013, J BIOL CHEM, V288, P27138, DOI 10.1074/jbc.M113.485094
   Vaghasiya Jitendra D, 2010, Saudi J Gastroenterol, V16, P174, DOI 10.4103/1319-3767.65187
   VANDENBERGHE G, 1977, BIOCHEM J, V162, P601, DOI 10.1042/bj1620601
   Vega VL, 2000, SHOCK, V14, P565, DOI 10.1097/00024382-200014050-00012
   Verdecchia P, 2000, HYPERTENSION, V36, P1072, DOI 10.1161/01.HYP.36.6.1072
   VINCENT MF, 1982, BIOCHEM J, V202, P117, DOI 10.1042/bj2020117
   Volterrani M, 2016, INT J CARDIOL, V213, P20, DOI 10.1016/j.ijcard.2015.08.088
   Vorbach C, 2003, TRENDS IMMUNOL, V24, P512, DOI 10.1016/S1471-4906(03)00237-0
   Wang J, 2014, PLOS ONE, V9, DOI [10.1371/journal.pone.0105125, 10.1371/journal.pone.0114259]
   Wang SL, 2015, J TRANSL MED, V13, DOI 10.1186/s12967-015-0578-x
   WANG XJ, 1992, J NUTR, V122, P1036, DOI 10.1093/jn/122.4.1036
   White CR, 1996, P NATL ACAD SCI USA, V93, P8745, DOI 10.1073/pnas.93.16.8745
   Wree A, 2014, J MOL MED, V92, P1069, DOI 10.1007/s00109-014-1170-1
   Xu CF, 2015, J HEPATOL, V62, P1412, DOI 10.1016/j.jhep.2015.01.019
   Yang CC, 2007, J PHYSIOL-LONDON, V582, P407, DOI 10.1113/jphysiol.2006.122747
   Yiginer O, 2008, CLIN RES CARDIOL, V97, P334, DOI 10.1007/s00392-007-0636-3
   Yoo TW, 2005, CIRC J, V69, P928, DOI 10.1253/circj.69.928
   YOSHIKAWA T, 1989, FREE RADICAL RES COM, V7, P285, DOI 10.3109/10715768909087953
   Yuan HP, 2015, J CLIN ENDOCR METAB, V100, P4198, DOI 10.1210/jc.2015-2527
   Zhou RB, 2010, NAT IMMUNOL, V11, P136, DOI 10.1038/ni.1831
   Zhu YZ, 2014, BIOCHEM BIOPH RES CO, V447, P707, DOI 10.1016/j.bbrc.2014.04.080
NR 180
TC 117
Z9 120
U1 0
U2 21
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2016
VL 2016
AR 8603164
DI 10.1155/2016/8603164
PG 15
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA EG1JU
UT WOS:000390789200001
PM 28070145
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Lim, HJ
   Seo, MS
   Shim, JY
   Kim, KE
   Shin, YH
   Lee, YJ
AF Lim, Hyoung-Ji
   Seo, Min-Seok
   Shim, Jae-Yong
   Kim, Kyu-Earn
   Shin, Youn Ho
   Lee, Yong-Jae
TI The association between platelet count and metabolic syndrome in
   children and adolescents
SO PLATELETS
LA English
DT Article
DE Adolescents; children; inflammation; metabolic syndrome; platelet count
ID INSULIN-RESISTANCE; HEMATOLOGICAL PARAMETERS; DIABETES-MELLITUS;
   OXIDATIVE STRESS; YOUNG ADULTHOOD; THROMBOPOIETIN; COMPONENTS;
   CHILDHOOD; DISEASE; GIRLS
AB The goal of this study was to evaluate the association between platelet count and metabolic syndrome (MetS) in children and adolescents in Korea. This study included data from 2228 subjects (1201 boys and 1027 girls) who participated in the 2010-2012 Korean National Health and Nutrition Examination Survey (KNHANES-V). We used the modified National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) criteria to define MetS. Odds ratios (95% confidence intervals [CIs]) for MetS were calculated with a multiple logistic regression analysis after adjusting for confounding factors across platelet count quartiles. The overall prevalence of MetS according to the modified NCEP-ATP III criteria was 4.9% (+/- 0.7%) in boys and 5.7% (+/- 0.9%) in girls. The prevalence of MetS significantly increased with increasing platelet quartiles in both boys and girls. In a multiple logistic regression analysis, the adjusted ORs (95% CIs) for the highest vs. the lowest quartile were 5.03 (1.30-19.48) in boys and 4.08 (1.20-13.93) in girls after adjusting for age and total cholesterol. Conclusions: Higher platelet count was associated with increased prevalence and risk of MetS in children and adolescents.
C1 [Lim, Hyoung-Ji; Seo, Min-Seok; Shim, Jae-Yong; Lee, Yong-Jae] Yonsei Univ, Coll Med, Dept Family Med, Gangnam Severance Hosp, Seoul 135720, South Korea.
   [Seo, Min-Seok] Yonsei Univ, Grad Sch Med, Dept Med, Seoul 135720, South Korea.
   [Kim, Kyu-Earn] Yonsei Univ, Gangnam Severance Hosp, Dept Pediat, Coll Med, Seoul 135720, South Korea.
   [Shin, Youn Ho] CHA Univ, Sch Med, Dept Pediat, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University; Yonsei University Health System; Pochon Cha
   University
RP Lee, YJ (corresponding author), Yonsei Univ, Coll Med, Dept Family Med, 211 Eonju Ro, Seoul 135720, South Korea.
EM ukyjhome@yuhs.ac
RI Seo, Minseok/JXM-0791-2024; Kim, Seong-Jun/KIJ-2249-2024; Lee, Yong
   Jae/GLR-4153-2022; Patthipati, Venkata Suresh/AAT-8233-2021; Shim, Jae
   Yong/GLU-2862-2022
OI Lee, Yong-Jae/0000-0002-6697-476X; Shim, JaeYong/0000-0002-9561-9230;
   Seo, Minseok/0000-0001-5551-4891
CR Ambring A, 2006, AM J CLIN NUTR, V83, P575, DOI 10.1093/ajcn.83.3.575
   Bonaccio M, 2014, BLOOD, V123, P3037, DOI 10.1182/blood-2013-12-541672
   Ceresa IF, 2007, PLATELETS, V18, P579, DOI 10.1080/09537100701593601
   Devaraj S, 2009, CURR OPIN LIPIDOL, V20, P182, DOI 10.1097/MOL.0b013e32832ac03e
   Eckel RH, 2010, LANCET, V375, P181, DOI 10.1016/S0140-6736(09)61794-3
   Fadini GP, 2012, ACTA DIABETOL, V49, P445, DOI 10.1007/s00592-012-0402-5
   Ford ES, 2007, CIRCULATION, V115, P2526, DOI 10.1161/CIRCULATIONAHA.106.657627
   Graversen L, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0089986
   Jesri Ammar, 2005, J Clin Hypertens (Greenwich), V7, P705, DOI 10.1111/j.1524-6175.2005.04809.x
   JONES RL, 1981, DIABETES, V30, P486, DOI 10.2337/diabetes.30.6.486
   Karamouzis I, 2011, HORM METAB RES, V43, P607, DOI 10.1055/s-0031-1284355
   Karbiner MS, 2013, LIFE SCI, V93, P503, DOI 10.1016/j.lfs.2013.08.003
   Katzmarzyk PT, 2001, J CLIN EPIDEMIOL, V54, P190, DOI 10.1016/S0895-4356(00)00315-2
   Kawamoto R, 2013, ENDOCRINE, V43, P334, DOI 10.1007/s12020-012-9662-7
   Kotani K, 2007, CLIN CHEM LAB MED, V45, P376, DOI 10.1515/CCLM.2007.063
   Lohsoonthorn V, 2007, DIABETES METAB SYND, V1, P143, DOI 10.1016/j.dsx.2007.05.002
   Maury E, 2010, OBESITY, V18, P1503, DOI 10.1038/oby.2009.464
   Morrison JA, 2005, PEDIATRICS, V116, P1178, DOI 10.1542/peds.2004-2358
   Nebeck K, 2012, DIABETES METAB SYND, V6, P22, DOI 10.1016/j.dsx.2012.05.009
   Romeo GR, 2012, ARTERIOSCL THROM VAS, V32, P1771, DOI 10.1161/ATVBAHA.111.241869
   Srinivasan SR, 2002, DIABETES, V51, P204, DOI 10.2337/diabetes.51.1.204
   Taniguchi A, 2003, METABOLISM, V52, P1246, DOI 10.1016/S0026-0495(03)00099-4
   The Korean Pediatric Society Health Statistics Committee, 2009, P KOR PED SOC HLTH S
   Turakhia MP, 2004, AM J CARDIOL, V94, P1406, DOI 10.1016/j.amjcard.2004.08.015
   Wilson PWF, 2005, CIRCULATION, V112, P3066, DOI 10.1161/CIRCULATIONAHA.105.539528
   Zareifar S, 2014, J CLIN LAB ANAL, V28, P245, DOI 10.1002/jcla.21673
NR 26
TC 19
Z9 19
U1 0
U2 9
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0953-7104
EI 1369-1635
J9 PLATELETS
JI Platelets
PY 2015
VL 26
IS 8
BP 758
EP 763
DI 10.3109/09537104.2014.995613
PG 6
WC Cell Biology; Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Hematology
GA DD4KT
UT WOS:000369892400008
PM 25549052
DA 2025-06-11
ER

PT J
AU Mosca, L
   Edelman, D
   Mochari, H
   Christian, AH
   Paultre, F
   Pollin, I
AF Mosca, L
   Edelman, D
   Mochari, H
   Christian, AH
   Paultre, F
   Pollin, I
TI Waist circumference predicts cardiometabolic and global Framingham risk
   among women screened during national woman's heart day
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
ID ACUTE MYOCARDIAL-INFARCTION; DISEASE RISK; ASSOCIATION; DEPRESSION;
   CHOLESTEROL; DIAGNOSIS; AWARENESS; OBESITY
AB Purpose: To evaluate the cardiometabolic risk profiles of 6938 women (mean age 49.2 +/- 14.6 years) attending the 2005 Sister to Sister: Everyone Has a Heart Foundation free public health standardized cardiovascular disease (CVD) risk factor screening events in 12 cities across the United States by race/ethnicity and waist circumference.
   Main findings: Among women without a history of CVD or diabetes (n = 6327), 90% were found to have at least one major modifiable CVD risk factor, with one-third of women having three or more major risk factors. Nearly half of all women with elevated total cholesterol (>= 200 mg/dL) or low high-density lipoprotein (HDL)-cholesterol (< 50 mg/dL) did not report a known history of abnormal cholesterol. Among women with no history of hypertension, 16% had a blood pressure >= 140/90 mm Hg. Unrecognized diabetes and glucose intolerance were striking among fasting women (n = 1218; 9% had a blood glucose >= 126 mg/dL and 43% had a blood glucose >= 100 mg/dL). In adjusted logistic regression models, women with a waist circumference >= 35 inches were more likely to have blood pressure >= 140/90 (OR = 1.9, p < 0.0001), total cholesterol >= 200 mg/dL (OR = 1.2, p = 0.006), HDL-cholesterol < 50 mg/dL (OR = 2.5, p < 0.0001), fasting glucose >= 100 mg/dL (OR = 2.0, p < 0.0001), and Framingham global risk score >= 10%, CVD or diabetes (OR = 2.0, p < 0.0001). Waist circumference was significantly correlated with Framingham global risk (r = 0.24, p < 0.001) and number of risk factors (r = 0.24, p < 0.0001). Increased clustering of risk factors was predictive of waist size >= 35 inches vs. < 35 inches in logistic models (p for trend > 0.0001). Among a subsample of women who underwent standardized screening for stress and depression, 62% had stress levels associated with increased cardiac risk, and 27% met criteria for clinical depression.
   Conclusions: Hypertension, dyslipidemia, and/or impaired fasting glucose were newly identified in approximately half the women screened. Waist size significantly correlated with clustering of risk factors, global Framingham risk score, CVD and diabetes, suggesting it may be an easily measured surrogate for women at increased risk of future cardiovascular clinical events who may benefit from further assessment and intervention.
C1 Columbia Univ, Med Ctr, New York State Psychiat Inst & Hosp, New York, NY 10032 USA.
C3 New York State Psychiatry Institute; Columbia University
RP Columbia Univ, Med Ctr, New York State Psychiat Inst & Hosp, 622 W 16th St,PH 10-203B, New York, NY 10032 USA.
EM ljm10@columbia.edu
OI Greenberger, Heidi Mochari/0000-0003-3334-0119
CR [Anonymous], DIABETES CARE S1
   Cassidy AE, 2005, CIRCULATION, V111, P1877, DOI 10.1161/01.CIR.0000161820.40494.5D
   Centers for Disease Control and Prevention (CDC), 2005, MMWR Morb Mortal Wkly Rep, V54, P113
   Cheng Susan, 2005, Prev Cardiol, V8, P11, DOI 10.1111/j.1520-037X.2005.3939.x
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   COBBAERT C, 1994, EUR J CLIN CHEM CLIN, V32, P391
   Ford DE, 1998, ARCH INTERN MED, V158, P1422, DOI 10.1001/archinte.158.13.1422
   Frasure-Smith N, 2003, JAMA-J AM MED ASSOC, V289, P3171, DOI 10.1001/jama.289.23.3171
   Genuth S, 2003, DIABETES CARE, V26, P3160
   Glassman AH, 1998, AM J PSYCHIAT, V155, P4, DOI 10.1176/ajp.155.1.4
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Kato Martha M, 2005, Prim Care Companion J Clin Psychiatry, V7, P115
   LADWIG KH, 1991, EUR HEART J, V12, P959
   Lear SA, 2003, METABOLISM, V52, P1295, DOI 10.1016/S0026-0495(03)00196-3
   Lespérance F, 2000, ARCH INTERN MED, V160, P1354, DOI 10.1001/archinte.160.9.1354
   Linfante Allison H, 2003, J Am Med Womens Assoc (1972), V58, P248
   Mosca L, 2004, J AM COLL CARDIOL, V43, P900, DOI 10.1016/j.jacc.2004.02.001
   Mosca L, 2004, CIRCULATION, V109, P573, DOI 10.1161/01.CIR.0000115222.69428.C9
   Nash IS, 2003, ARCH INTERN MED, V163, P1597, DOI 10.1001/archinte.163.13.1597
   National Research Council, 1998, NIH PUBL, P56
   Norhammar A, 2002, LANCET, V359, P2140, DOI 10.1016/S0140-6736(02)09089-X
   Rosengren A, 2004, LANCET, V364, P953, DOI 10.1016/S0140-6736(04)17019-0
   Sirois BC, 2003, BEHAV MODIF, V27, P83, DOI 10.1177/0145445502238695
   Smith DA, 2005, DIABETES OBES METAB, V7, P370, DOI 10.1111/j.1463-1326.2004.00406.x
   Stoddard AM, 2004, J WOMENS HEALTH, V13, P539, DOI 10.1089/1540999041281106
   Tankó LB, 2005, CIRCULATION, V111, P1883, DOI 10.1161/01.CIR.0000161801.65408.8D
   Valsamakis G, 2004, DIABETIC MED, V21, P1339, DOI 10.1111/j.1464-5491.2004.01361.x
   Ziegelstein R.C., 2003, Behavioral Medicine, V3, P150
   1998, MMWR, V47, P91
NR 29
TC 15
Z9 20
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
EI 1931-843X
J9 J WOMENS HEALTH
JI J. Womens Health
PD JAN
PY 2006
VL 15
IS 1
BP 24
EP 34
DI 10.1089/jwh.2006.15.24
PG 11
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal; Obstetrics & Gynecology; Women's Studies
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal
   Medicine; Obstetrics & Gynecology; Women's Studies
GA 007RY
UT WOS:000234988500005
PM 16417415
DA 2025-06-11
ER

PT J
AU Kim, YH
   Kim, JJ
   Kim, SM
   Choi, Y
   Jeon, MJ
AF Kim, Yun Hwan
   Kim, Jin Ju
   Kim, Sun Mie
   Choi, Yunhee
   Jeon, Myung Jae
TI Association between metabolic syndrome and pelvic floor dysfunction in
   middle-aged to older Korean women
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Article
DE metabolic syndrome; pelvic floor distress inventory (PFDI); pelvic floor
   dysfunction
ID URINARY-TRACT SYMPTOMS; DIABETES-MELLITUS; NATIONAL-HEALTH;
   RISK-FACTORS; DISORDERS; OBESITY; INCONTINENCE; PREVALENCE; BLADDER;
   STRESS
AB OBJECTIVE: The purpose of this study was to evaluate the association of metabolic syndrome (MS) with female pelvic floor dysfunction in middle-aged to older Korean women.
   STUDY DESIGN: A prospective cross-sectional study was performed that included a total of 984 Korean women (>= 40 years old) who visited a comprehensive medical screening clinic. Pelvic floor dysfunction was assessed by the Pelvic Floor Distress Inventory-20 (PFDI-20); higher scores indicated a greater symptom burden.
   RESULTS: The adjusted mean score on the PFDI-20, and especially the Urinary Distress Inventory-6 subscale, was significantly higher in subjects with MS than those without MS. Furthermore, the PFDI-20 and all 3 subscales were significantly increased in correlation with the number of MS components that were present (P < .05). In the multivariable analysis, MS was associated significantly with PFDI-20 (P = .002) and the 3 subscores (P < .05).
   CONCLUSION: MS was significantly associated with the pelvic floor dysfunction among middle-to old-aged Korean women. Physicians should pay more attention to the pelvic floor symptoms for the patients with MS.
C1 [Jeon, Myung Jae] Seoul Natl Univ, Coll Med, Dept Obstet & Gynecol, Seoul 110744, South Korea.
   [Kim, Yun Hwan] Ewha Womans Univ, Dept Obstet & Gynecol, Sch Med, Seoul, South Korea.
   [Kim, Yun Hwan] Ewha Womans Univ, Med Res Inst, Sch Med, Seoul, South Korea.
   [Kim, Jin Ju; Kim, Sun Mie] Seoul Natl Univ Hosp Hlth Care Syst, GangNam Ctr, Dept Obstet & Gynecol, Seoul, South Korea.
   [Choi, Yunhee] Seoul Natl Univ Hosp, Med Res Collaborating Ctr, Seoul 110744, South Korea.
C3 Seoul National University (SNU); Ewha Womans University; Ewha Womans
   University; Seoul National University (SNU); Seoul National University
   Hospital; Seoul National University (SNU); Seoul National University
   Hospital
RP Jeon, MJ (corresponding author), Seoul Natl Univ, Coll Med, Dept Obstet & Gynecol, 28 Yongon Dong, Seoul 110744, South Korea.
EM jeonmj@snu.ac.kr
RI Choi, You-Jung/AFR-4193-2022; Kim, Jin/C-4294-2013; Kim, Kwang
   Pyo/AAG-1815-2020; Jeon, Myung/O-2486-2019
OI Kim, Yun Hwan/0000-0001-9498-2938; Jeon, Myung Jae/0000-0001-5582-1488
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Azadzoi KM, 2010, J UROLOGY, V183, P362, DOI 10.1016/j.juro.2009.08.103
   Badia X, 1997, EUR UROL, V31, P129
   Barber MD, 2006, AM J OBSTET GYNECOL, V195, P942, DOI 10.1016/j.ajog.2006.02.050
   Barber MD, 2005, AM J OBSTET GYNECOL, V193, P103, DOI 10.1016/j.ajog.2004.12.025
   Barber MD, 2001, AM J OBSTET GYNECOL, V185, P1388, DOI 10.1067/mob.2001.118659
   BARRY MJ, 1992, J UROLOGY, V148, P1549, DOI 10.1016/S0022-5347(17)36966-5
   Bradley CS, 2005, OBSTET GYNECOL, V106, P759, DOI 10.1097/01.AOG.0000180183.03897.72
   Brown JS, 2006, DIABETES CARE, V29, P1307, DOI 10.2337/dc05-2463
   Cellek S, 1999, BRIT J PHARMACOL, V128, P1804, DOI 10.1038/sj.bjp.0702981
   Danforth KN, 2009, J UROLOGY, V181, P193, DOI 10.1016/j.juro.2008.09.007
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   Greer WJ, 2008, OBSTET GYNECOL, V112, P341, DOI 10.1097/AOG.0b013e31817cfdde
   Gutman RE, 2008, AM J OBSTET GYNECOL, V199, DOI 10.1016/j.ajog.2008.07.028
   Han MO, 2006, INT UROGYNECOL J, V17, P35, DOI 10.1007/s00192-005-1356-8
   Handa VL, 2008, OBSTET GYNECOL, V111, P1045, DOI 10.1097/AOG.0b013e31816bbe85
   Hara K, 2006, DIABETES CARE, V29, P1123, DOI 10.2337/dc05-2540
   Kanazawa M, 2002, ASIA PAC J CLIN NUTR, V11, pS732, DOI 10.1046/j.1440-6047.11.s8.19.x
   Lawrence JM, 2007, DIABETES CARE, V30, P2536, DOI 10.2337/dc07-0262
   Nixon A, 2005, J UROLOGY, V174, P604, DOI 10.1097/01.ju.0000165461.38088.7b
   Nygaard I, 2008, JAMA-J AM MED ASSOC, V300, P1311, DOI 10.1001/jama.300.11.1311
   Park HS, 2007, DIABETES OBES METAB, V9, P50, DOI 10.1111/j.1463-1326.2005.00569.x
   Persson K, 1998, AM J PHYSIOL-REG I, V275, pR1366, DOI 10.1152/ajpregu.1998.275.4.R1366
   Ponholzer A, 2006, EUR UROL, V50, P581, DOI 10.1016/j.eururo.2006.01.031
   Shenfeld OZ, 2005, UROLOGY, V65, P181, DOI 10.1016/j.urology.2004.08.055
   Steers WD, 1999, EXP PHYSIOL, V84, P137, DOI 10.1111/j.1469-445X.1999.tb00079.x
   Subak LL, 2009, NEW ENGL J MED, V360, P481, DOI 10.1056/NEJMoa0806375
   Tai HC, 2010, J CLIN ENDOCR METAB, V95, P1143, DOI 10.1210/jc.2009-1492
   Temml C, 2009, UROLOGY, V73, P544, DOI 10.1016/j.urology.2008.10.027
NR 30
TC 12
Z9 12
U1 1
U2 5
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
EI 1097-6868
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JUL
PY 2011
VL 205
IS 1
AR 71.e1
DI 10.1016/j.ajog.2011.02.047
PG 8
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 783KX
UT WOS:000292082400038
PM 21481837
DA 2025-06-11
ER

PT J
AU Szydlarska, J
   Weiss, C
   Marycz, K
AF Szydlarska, Joanna
   Weiss, Christine
   Marycz, Krzysztof
TI The Effect of Methyl-β-cyclodextrin on Apoptosis, Proliferative
   Activity, and Oxidative Stress in Adipose-Derived Mesenchymal Stromal
   Cells of Horses Suffering from Metabolic Syndrome (EMS)
SO MOLECULES
LA English
DT Article
DE equine metabolic syndrome; mesenchymal stem cells;
   methyl-beta-cyclodextrin; cyclodextrin; stem cells
ID MEMBRANE CHOLESTEROL; GLUCOSE-TRANSPORT; INSULIN-SECRETION; LIPID RAFTS;
   STEM-CELLS; GLUT4; ADIPOCYTES; DISEASE; OBESITY; TRANSLOCATION
AB Methyl-beta-cyclodextrin (M beta CD) is a cyclic oligosaccharide, commonly used as a pharmacological agent to deplete membrane cholesterol. In this study, we examined the effect of M beta CD on adipose-derived mesenchymal stromal cells (ASCs) isolated form healthy horses (ASC(CTRL)) and from horses suffering from metabolic syndrome (ASC(EMS)). We investigated the changes in the mRNA levels of the glucose transporter 4 (GLUT4) and found that M beta CD application may lead to a significant improvement in glucose transport in ASC(EMS). We also showed that M beta CD treatment affected GLUT4 upregulation in an insulin-independent manner via an NO-dependent signaling pathway. Furthermore, the analysis of superoxide dismutase activity (SOD) and reactive oxygen species (ROS) levels showed that M beta CD treatment was associated with an increased antioxidant capacity in ASC(EMS). Moreover, we indicated that methyl-beta-cyclodextrin treatment did not cause a dysfunction of the endoplasmic reticulum and lysosomes. Thereby, we propose the possibility of improving the functionality of ASC(EMS) by increasing their metabolic stability.
C1 [Szydlarska, Joanna; Weiss, Christine; Marycz, Krzysztof] Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, PL-50631 Wroclaw, Poland.
   [Szydlarska, Joanna; Weiss, Christine; Marycz, Krzysztof] Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Electron Microscope Facil, PL-50631 Wroclaw, Poland.
   [Marycz, Krzysztof] Wroclaw Res Ctr EIT, PL-54066 Wroclaw, Poland.
C3 Wroclaw University of Environmental & Life Sciences; Wroclaw University
   of Environmental & Life Sciences
RP Marycz, K (corresponding author), Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, PL-50631 Wroclaw, Poland.; Marycz, K (corresponding author), Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Electron Microscope Facil, PL-50631 Wroclaw, Poland.; Marycz, K (corresponding author), Wroclaw Res Ctr EIT, PL-54066 Wroclaw, Poland.
EM joanna.szydlarska@gmail.com; d.weiss@horsedoc.ch;
   krzysztofmarycz@interia.pl
FU Ministry of Science and Higher Education, Poland [DI2016/009246];
   Leading National Research Centre (KNOW, Krajowy Naukowy Osrodek Wiodacy)
   program
FX The authors thank Jakub Grzesiak for performing the TEM analysis. This
   study was financially supported by research project No. DI2016/009246
   (Ministry of Science and Higher Education, Poland) awarded to Joanna
   Szydlarska. We acknowledge the Leading National Research Centre (KNOW,
   Krajowy Naukowy Osrodek Wiodacy) program for years 2014-2018 for
   covering the publication fee.
CR Al-Makdissy N, 2003, CELL SIGNAL, V15, P1019, DOI 10.1016/S0898-6568(03)00070-6
   Antonescu CN, 2009, BIOSCIENCE REP, V29, P1, DOI 10.1042/BSR20080105
   Ballabio A, 2009, BBA-MOL CELL RES, V1793, P684, DOI 10.1016/j.bbamcr.2008.12.001
   Baraniak PR, 2010, REGEN MED, V5, P121, DOI 10.2217/RME.09.74
   Barnes K, 2004, BIOCHEM J, V378, P343, DOI 10.1042/BJ20031186
   Basinska K, 2015, J VET SCI, V16, P113, DOI [10.4142/jvs.2015.16.1.113, 10.4142/jvs.2015.16.1.107]
   Cavener DR, 2010, TRENDS ENDOCRIN MET, V21, P714, DOI 10.1016/j.tem.2010.08.005
   Chang L, 2004, MOL MED, V10, P65, DOI 10.2119/2005-00029.Saltiel
   Choi YA, 2004, EXP MOL MED, V36, P78, DOI 10.1038/emm.2004.11
   CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1006/abio.1987.9999
   Christian AE, 1997, J LIPID RES, V38, P2264
   Das A, 2014, ELIFE, V3, DOI 10.7554/eLife.02882
   Diaz-Arjonilla M, 2009, INT J IMPOT RES, V21, P89, DOI 10.1038/ijir.2008.42
   Ertelt A, 2014, ENDOCR CONNECT, V3, pR81, DOI 10.1530/EC-14-0038
   Garofalo T, 2016, AUTOPHAGY, V12, P917, DOI 10.1080/15548627.2016.1160971
   Gheibi S, 2017, NITRIC OXIDE-BIOL CH, V64, P39, DOI 10.1016/j.niox.2017.01.003
   Giles SL, 2014, PEERJ, V2, DOI 10.7717/peerj.299
   Goluszko P, 2005, INFECT IMMUN, V73, P7791, DOI 10.1128/IAI.73.12.7791-7796.2005
   Grantham JP, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0099776
   Gylling H, 2010, J LIPID RES, V51, P2422, DOI 10.1194/jlr.P006619
   Habegger KM, 2012, ENDOCRINOLOGY, V153, P2130, DOI 10.1210/en.2011-2099
   Hailstones D, 1998, J LIPID RES, V39, P369
   Hallikainen M, 2006, AM J CLIN NUTR, V84, P1385, DOI 10.1093/ajcn/84.6.1385
   Hao M, 2007, DIABETES, V56, P2328, DOI 10.2337/db07-0056
   Huang SH, 2007, CELL METAB, V5, P237, DOI 10.1016/j.cmet.2007.03.006
   Ikonen E, 2006, PHYSIOL REV, V86, P1237, DOI 10.1152/physrev.00022.2005
   Kameyama K, 2017, INT J NANOMED, V12, P3433, DOI 10.2147/IJN.S133482
   Karlsson M, 2001, FASEB J, V15, P249, DOI 10.1096/fj.01-0646fje
   Le Lay S, 2001, J BIOL CHEM, V276, P16904, DOI 10.1074/jbc.M010955200
   Llanos P, 2015, AM J PHYSIOL-ENDOC M, V308, pE294, DOI 10.1152/ajpendo.00189.2014
   Mahavadi S., 2014, FASEB J, V28
   Maredziak M, 2015, IN VITRO CELL DEV-AN, V51, P230, DOI 10.1007/s11626-014-9828-0
   Marycz K, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/4710326
   Marycz K, 2016, J CELL MOL MED, V20, P2384, DOI 10.1111/jcmm.12932
   Matsushita K, 2016, STEM CELLS INT, V2016, DOI 10.1155/2016/2892840
   Merry TL, 2009, IUBMB LIFE, V61, P479, DOI 10.1002/iub.179
   Portilho DM, 2012, EUR J PHARMACOL, V694, P1, DOI 10.1016/j.ejphar.2012.07.035
   Rudrappa B. G., 2012, GLOB J MED RES, V12, P18
   Sarkar S, 2013, CELL REP, V5, P1302, DOI 10.1016/j.celrep.2013.10.042
   Tanaka S, 1997, CLIN CARDIOL, V20, P361, DOI 10.1002/clc.4960200412
   Tanaka T, 2003, EUR J ENDOCRINOL, V149, P61, DOI 10.1530/eje.0.1490061
   Wei X, 2013, ACTA PHARMACOL SIN, V34, P747, DOI 10.1038/aps.2013.50
   Zidovetzki R, 2007, BBA-BIOMEMBRANES, V1768, P1311, DOI 10.1016/j.bbamem.2007.03.026
NR 43
TC 3
Z9 4
U1 0
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD FEB
PY 2018
VL 23
IS 2
AR 287
DI 10.3390/molecules23020287
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA FX9PK
UT WOS:000426436300067
PM 29385746
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Choudhury, J
   Sanyal, AJ
AF Choudhury, J
   Sanyal, AJ
TI Insulin resistance in NASH
SO FRONTIERS IN BIOSCIENCE-LANDMARK
LA English
DT Article
DE fatty liver; nonalcoholic steatohepatitis; nonalcoholic fatty liver
   disease; nonalcoholic fatty liver; insulin resistance; free fatty acids;
   oxidative stress; metabolic syndrome; obesity; review
ID ACTIVATED RECEPTOR-ALPHA; FATTY-ACID OXIDATION; PROTEIN-KINASE-C;
   HEPATIC CYTOCHROME-P450 2E1; PEROXISOMAL BETA-OXIDATION; METABOLIC
   SYNDROME; NONALCOHOLIC STEATOHEPATITIS; POTENTIAL ROLE; GLUCOSE-UPTAKE;
   LIVER-DISEASE
AB Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease observed in the clinical practice of hepatology. The coexistence of metabolic syndrome in this cohort of patients has made insulin resistance central to the pathogenesis of these disorders. The metabolic consequence of insulin resistance is impaired hepatic glucose output and abnormal lipid handling. In the face of continued metabolic insults the normal hepatic regulatory mechanism gets overwhelmed and fat accumulates in the hepatocytes. The subsequent fate of steatotic hepatocytes depends on the capacity of additional factors such as adipocytokines and toxicity induced by the free fatty acids themselves to induce inflammatory response. This latter process is responsible for the producing the phenotype of non-alcoholic steatohepatitis (NASH). Irrespective of the process by which these phenotypic response occurs, it is now universally accepted that in the absence of insulin resistance the spectrum of changes one associates with NAFLD does not develop. In this review we will discuss the various processes that are involved in the pathogenesis of NAFLD.
C1 Virginia Commonwealth Univ, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, Richmond, VA USA.
C3 Virginia Commonwealth University
RP MCV Box 980711, Richmond, VA 23298 USA.
EM ajsanyal@hsc.vcu.edu
CR Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Alessi DR, 1997, CURR BIOL, V7, P261, DOI 10.1016/S0960-9822(06)00122-9
   Baumann CA, 2000, NATURE, V407, P202, DOI 10.1038/35025089
   BEALE EG, 1986, DIABETES, V35, P546, DOI 10.2337/diabetes.35.5.546
   BERGMAN RN, 1979, AM J PHYSIOL, V236, pE667, DOI 10.1152/ajpendo.1979.236.6.E667
   Bergman RN, 1997, RECENT PROG HORM RES, V52, P359
   Berson A, 1998, GASTROENTEROLOGY, V114, P764, DOI 10.1016/S0016-5085(98)70590-6
   BOULTON TG, 1991, CELL, V65, P663, DOI 10.1016/0092-8674(91)90098-J
   Brady MJ, 1997, J BIOL CHEM, V272, P29698, DOI 10.1074/jbc.272.47.29698
   Brunt EM, 1999, AM J GASTROENTEROL, V94, P2467, DOI 10.1111/j.1572-0241.1999.01377.x
   CATURELLI E, 1992, J GASTROEN HEPATOL, V7, P469, DOI 10.1111/j.1440-1746.1992.tb01022.x
   Chakravarty K, 2004, J BIOL CHEM, V279, P15385, DOI 10.1074/jbc.M309905200
   Chalasani N, 2003, HEPATOLOGY, V37, P544, DOI 10.1053/jhep.2003.50095
   Charlton N, 2002, HEPATOLOGY, V35, P898, DOI 10.1053/jhep.2002.32527
   Chiang SH, 2001, NATURE, V410, P944, DOI 10.1038/35073608
   Chien D, 2000, AM J PHYSIOL-ENDOC M, V279, pE259, DOI 10.1152/ajpendo.2000.279.2.E259
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Day CP, 2002, BEST PRACT RES CL GA, V16, P663, DOI 10.1053/bega.2002.0333
   DE W, 1995, MOL PHARM, V47, P474
   DEFRONZO RA, 1979, AM J PHYSIOL, V237, pE214
   Díez JJ, 2003, EUR J ENDOCRINOL, V148, P293, DOI 10.1530/eje.0.1480293
   Du KY, 2003, SCIENCE, V300, P1574, DOI 10.1126/science.1079817
   FLIER JS, 1992, DIABETES, V41, P1207, DOI 10.2337/diabetes.41.9.1207
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Foufelle F, 2002, BIOCHEM J, V366, P377, DOI 10.1042/BJ20020430
   FUSAMOTO H, 1991, J NUTR SCI VITAMINOL, V37, pS71, DOI 10.3177/jnsv.37.Supplement_S71
   GALVIN P, 1992, DIABETIC MED, V9, P921, DOI 10.1111/j.1464-5491.1992.tb01732.x
   Garg A, 2000, AM J MED, V108, P143, DOI 10.1016/S0002-9343(99)00414-3
   Goldstein BJ, 1998, VITAM HORM, V54, P67, DOI 10.1016/S0083-6729(08)60922-X
   Goodpaster BH, 1997, DIABETES, V46, P1579, DOI 10.2337/diabetes.46.10.1579
   GROUND KEU, 1984, AVIAT SPACE ENVIR MD, V55, P59
   GULICK T, 1994, P NATL ACAD SCI USA, V91, P11012, DOI 10.1073/pnas.91.23.11012
   Hällsten K, 2003, OBES RES, V11, P257, DOI 10.1038/oby.2003.39
   Harris RBS, 2000, ANNU REV NUTR, V20, P45, DOI 10.1146/annurev.nutr.20.1.45
   Hashimoto T, 1999, J BIOL CHEM, V274, P19228, DOI 10.1074/jbc.274.27.19228
   Hashimoto T, 2000, J BIOL CHEM, V275, P28918, DOI 10.1074/jbc.M910350199
   Hedley AA, 2004, JAMA-J AM MED ASSOC, V291, P2847, DOI 10.1001/jama.291.23.2847
   Hube F, 1999, HORM METAB RES, V31, P626, DOI 10.1055/s-2007-978810
   Itani SI, 2002, DIABETES, V51, P2005, DOI 10.2337/diabetes.51.7.2005
   KAHN CR, 1978, P NATL ACAD SCI USA, V75, P4209, DOI 10.1073/pnas.75.9.4209
   Kanzaki M, 2003, CURR BIOL, V13, pR574, DOI 10.1016/S0960-9822(03)00478-0
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   Kekäläinen P, 2000, METABOLISM, V49, P1247, DOI 10.1053/meta.2000.9514
   Kersten S, 1999, J CLIN INVEST, V103, P1489, DOI 10.1172/JCI6223
   Kim SY, 2004, J BIOL CHEM, V279, P30823, DOI 10.1074/jbc.M313223200
   Klein J, 1999, J BIOL CHEM, V274, P34795, DOI 10.1074/jbc.274.49.34795
   Kuczmarski RJ, 1997, OBES RES, V5, P542, DOI 10.1002/j.1550-8528.1997.tb00575.x
   LAAKSO M, 1990, ARTERIOSCLEROSIS, V10, P223, DOI 10.1161/01.ATV.10.2.223
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lam TKT, 2003, AM J PHYSIOL-ENDOC M, V284, pE281, DOI 10.1152/ajpendo.00332.2002
   Lam TKT, 2002, AM J PHYSIOL-ENDOC M, V283, pE682, DOI 10.1152/ajpendo.00038.2002
   Leclercq IA, 2000, J CLIN INVEST, V105, P1067, DOI 10.1172/JCI8814
   Leone TC, 1999, P NATL ACAD SCI USA, V96, P7473, DOI 10.1073/pnas.96.13.7473
   Marceau P, 1999, J CLIN ENDOCR METAB, V84, P1513, DOI 10.1210/jc.84.5.1513
   Marchesini G, 1999, AM J MED, V107, P450, DOI 10.1016/S0002-9343(99)00271-5
   Matsuda M, 1999, DIABETES CARE, V22, P1462, DOI 10.2337/diacare.22.9.1462
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   MOFRAD PS, RELATIONSHIP METABOL
   Nakae J, 1999, J PEDIATR ENDOCR MET, V12, P721
   Nakae J, 1999, J BIOL CHEM, V274, P15982, DOI 10.1074/jbc.274.23.15982
   Neuschwander-Tetri BA, 2003, HEPATOLOGY, V38, P1008, DOI 10.1053/jhep.2003.50420
   Newgard CB, 2000, DIABETES, V49, P1967, DOI 10.2337/diabetes.49.12.1967
   Nieto N, 2002, J BIOL CHEM, V277, P9853, DOI 10.1074/jbc.M110506200
   OLEFSKY J, 1973, DIABETES, V22, P507, DOI 10.2337/diab.22.7.507
   Pagano G, 2002, HEPATOLOGY, V35, P367, DOI 10.1053/jhep.2002.30690
   Paterson JM, 2004, P NATL ACAD SCI USA, V101, P7088, DOI 10.1073/pnas.0305524101
   Patti Mary-Elizabeth, 1998, Journal of Basic and Clinical Physiology and Pharmacology, V9, P89
   Pérez-Carreras M, 2003, HEPATOLOGY, V38, P999, DOI 10.1053/jhep.2003.50398
   Pessayre D, 2002, AM J PHYSIOL-GASTR L, V282, pG193, DOI 10.1152/ajpgi.00426.2001
   Pessayre D, 2001, SEMIN LIVER DIS, V21, P57, DOI 10.1055/s-2001-12929
   Pessin JE, 2000, J CLIN INVEST, V106, P165, DOI 10.1172/JCI10582
   Pi-Sunyer FX, 2002, OBES RES, V10, p97S, DOI 10.1038/oby.2002.202
   PILKIS SJ, 1992, ANNU REV PHYSIOL, V54, P885, DOI 10.1146/annurev.physiol.54.1.885
   Prentki M, 1996, DIABETES, V45, P273, DOI 10.2337/diabetes.45.3.273
   Rao MS, 2001, SEMIN LIVER DIS, V21, P43, DOI 10.1055/s-2001-12928
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Reddy JK, 2001, AM J PHYSIOL-GASTR L, V281, pG1333, DOI 10.1152/ajpgi.2001.281.6.G1333
   Saltiel AR, 2001, NATURE, V414, P799, DOI 10.1038/414799a
   Sanyal AJ, 2001, GASTROENTEROLOGY, V120, P1183, DOI 10.1053/gast.2001.23256
   Sanyal Arun J, 2002, Gastroenterology, V123, P1705, DOI 10.1053/gast.2002.36572
   Schwarz JM, 2003, AM J CLIN NUTR, V77, P43, DOI 10.1093/ajcn/77.1.43
   Sentí M, 2003, J CLIN ENDOCR METAB, V88, P5422, DOI 10.1210/jc.2003-030648
   Shimano H, 2001, PROG LIPID RES, V40, P439, DOI 10.1016/S0163-7827(01)00010-8
   Standaert ML, 1997, J BIOL CHEM, V272, P30075, DOI 10.1074/jbc.272.48.30075
   Sugden MC, 2004, DIABETES, V53, pS71, DOI 10.2337/diabetes.53.2007.S71
   SWISLOCKI ALM, 1987, DIABETOLOGIA, V30, P622
   TIERNEY DJ, 1992, ARCH BIOCHEM BIOPHYS, V293, P9, DOI 10.1016/0003-9861(92)90358-4
   Tomlinson JW, 2000, ENDOCR RES, V26, P711, DOI 10.3109/07435800009048591
   Ueki K, 2004, P NATL ACAD SCI USA, V101, P10422, DOI 10.1073/pnas.0402511101
   Videla LA, 2004, CLIN SCI, V106, P261, DOI 10.1042/CS20030285
   WANLESS IR, 1989, MODERN PATHOL, V2, P69
   WANLESS IR, 1990, HEPATOLOGY, V12, P1106, DOI 10.1002/hep.1840120505
   Watson RT, 2001, J CELL BIOL, V154, P829, DOI 10.1083/jcb.200102078
   Weltman MD, 1998, HEPATOLOGY, V27, P128, DOI 10.1002/hep.510270121
   Woodcroft KJ, 2002, HEPATOLOGY, V35, P263, DOI 10.1053/jhep.2002.30691
   Woodcroft KJ, 1997, CHEM-BIOL INTERACT, V107, P75, DOI 10.1016/S0009-2797(97)00075-6
   Younossi ZM, 2004, CLIN GASTROENTEROL H, V2, P262, DOI 10.1016/S1542-3565(04)00014-X
   Zhang M, 2001, J BIOL CHEM, V276, P41690, DOI 10.1074/jbc.M105117200
NR 98
TC 41
Z9 46
U1 0
U2 1
PU FRONTIERS IN BIOSCIENCE INC
PI IRVINE
PA 16471 SCIENTIFIC WAY, IRVINE, CA 92618 USA
SN 1093-9946
EI 1093-4715
J9 FRONT BIOSCI-LANDMRK
JI Front. Biosci.
PD MAY 1
PY 2005
VL 10
BP 1520
EP 1533
PG 14
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 970OP
UT WOS:000232319800043
PM 15769642
DA 2025-06-11
ER

PT J
AU Lai, MD
   Ong, KC
   Arumugam, B
   Kuppusamy, UR
AF Lai, Muhammad Dhia
   Ong, Kien Chai
   Arumugam, Bavani
   Kuppusamy, Umah Rani
TI Nutritional composition, efficacy and mechanisms of oyster mushrooms
   (Pleurotus spp.) in preventing metabolic syndrome: Insights into
   perspectives and challenges
SO FOOD BIOSCIENCE
LA English
DT Article
DE Pleurotus; Oyster mushrooms; Nutritional properties; Metabolic syndrome
ID EDIBLE MUSHROOMS; PROVISIONAL REPORT; GANODERMA-LUCIDUM; OXIDATIVE
   STRESS; AQUEOUS EXTRACT; FATTY LIVER; OSTREATUS; DIAGNOSIS; GLUCANS;
   POLYSACCHARIDES
AB The worldwide prevalence of metabolic syndrome (MetS) and its related complications such as diabetes and cardiovascular disease have been increasing steadily. Apart from realigning dietary intake habits and exercising regularly, consuming food with health benefits could help patients with MetS improve their health. Oyster mushrooms (genus Pleurotus) are among the most common edible mushrooms explored for potential use for combating MetS due to their high nutritional contents with additional bioactive components. Besides, numerous high-fat diets and drug-induced hyperglycemic animal studies have revealed the ability of oyster mushrooms to improve MetS-related conditions by targeting different mechanisms. Several clinical studies have shown varying efficacy levels of the mushrooms in combatting MetS and related complications. However, these findings have yet to be compared and reviewed to provide an overview and meaningful inferences on the benefits of the mushroom against MetS. This review will provide insights and updates on the nutritional composition, efficacy and mechanisms of oyster mushrooms in preventing or attenuating MetS-related conditions, as well as the perspectives and challenges of introducing these mushrooms as food products with health benefits.
C1 [Lai, Muhammad Dhia; Ong, Kien Chai; Arumugam, Bavani; Kuppusamy, Umah Rani] Univ Malaya, Fac Med, Dept Biomed Sci, Kuala Lumpur 50603, Malaysia.
   [Kuppusamy, Umah Rani] Univ Malaya, Mushroom Res Ctr, Kuala Lumpur 50603, Malaysia.
C3 Universiti Malaya; Universiti Malaya
RP Kuppusamy, UR (corresponding author), Univ Malaya, Fac Med, Dept Biomed Sci, Kuala Lumpur 50603, Malaysia.; Kuppusamy, UR (corresponding author), Univ Malaya, Mushroom Res Ctr, Kuala Lumpur 50603, Malaysia.
EM umah@um.edu.my
RI KUPPUSAMY, UMAH RANI/B-9981-2010; Arumugam, Bavani/GRR-5995-2022; ONG,
   KIEN CHAI/B-9452-2010; Lai, Muhammad Dhia/JSL-6141-2023
OI Lai, Muhammad Dhia/0009-0003-7572-5006
FU Universiti Malaya Impact Oriented Interdisciplinary Research Grant
   [IIRG005B-19HWB]
FX This research is supported by Universiti Malaya Impact Oriented
   Interdisciplinary Research Grant (IIRG005B-19HWB) .
CR Acosta-Urdapilleta ML, 2020, J ENVIRON BIOL, V41, P1075, DOI 10.22438/jeb/41/5/MRN-1307
   Adeyi A. O., 2021, Clinical Phytoscience, V7, P1, DOI [10.1186/s40816-021-00321-0, DOI 10.1186/S40816-021-00321-0]
   Afolabi F. J., 2021, American Journal of Food Science and Health, V7, P97
   Agunloye OM, 2022, FOOD FRONTIERS, V3, P161, DOI 10.1002/fft2.111
   Ahima R. S., 2023, Metabolic syndrome: A comprehensive textbook, P739, DOI [10.1007/978-3-031-40116-945, DOI 10.1007/978-3-031-40116-945]
   Ahmad I, 2023, TRENDS FOOD SCI TECH, V134, P123, DOI 10.1016/j.tifs.2023.03.007
   Al Nahdi AMT, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/7054272
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   ALDEEN IHS, 1987, J ETHNOPHARMACOL, V21, P297, DOI 10.1016/0378-8741(87)90105-X
   Alemayehu GF, 2021, HELIYON, V7, DOI 10.1016/j.heliyon.2021.e07722
   Alexander JT, 2022, J GEN INTERN MED, V37, P415, DOI 10.1007/s11606-021-07105-9
   Aly AA, 2021, ARAB J CHEM, V14, DOI 10.1016/j.arabjc.2021.103112
   Amerikanou C, 2023, FOODS, V12, DOI 10.3390/foods12020353
   Amirullah NA, 2021, BIOCATAL AGR BIOTECH, V34, DOI 10.1016/j.bcab.2021.102019
   Anderson KC, 2023, ADV NUTR, V14, P1226, DOI 10.1016/j.advnut.2023.07.011
   Atri N., 2018, Fungi, P372
   Audrey T.T.K., 2021, CAMEROON J BIOL BIOC, V29, P100
   Azevedo S, 2017, J FOOD ENG, V212, P108, DOI 10.1016/j.jfoodeng.2017.05.026
   Bach F, 2017, INT J FOOD SCI TECH, V52, P2382, DOI 10.1111/ijfs.13522
   Bai JY, 2021, FOOD BIOSCI, V41, DOI 10.1016/j.fbio.2021.101010
   Bailén M, 2020, FRONT NUTR, V7, DOI 10.3389/fnut.2020.583608
   Bains A, 2021, J FOOD SCI TECH MYS, V58, P3328, DOI 10.1007/s13197-020-04891-8
   Balaji P, 2020, SAUDI J BIOL SCI, V27, P913, DOI 10.1016/j.sjbs.2020.01.027
   Balkau B, 1999, DIABETIC MED, V16, P442
   Bamidele OP, 2020, OPEN AGRIC, V5, P40, DOI 10.1515/opag-2020-0007
   Bellettini MB, 2018, REV ARGENT MICROBIOL, V50, P216, DOI 10.1016/j.ram.2017.08.007
   Bellettini MB, 2019, SAUDI J BIOL SCI, V26, P633, DOI 10.1016/j.sjbs.2016.12.005
   Bermúdez R, 2023, FOODS, V12, DOI 10.3390/foods12020391
   Bishehsari F, 2020, NAT REV ENDOCRINOL, V16, P731, DOI 10.1038/s41574-020-00427-4
   Bita AM., 2022, Open J Appl Sci, V12, P256, DOI [10.4236/ojapps.2022.122019, DOI 10.4236/OJAPPS.2022.122019]
   Blumfield M, 2020, J NUTR BIOCHEM, V84, DOI 10.1016/j.jnutbio.2020.108453
   Brunt VE, 2020, HYPERTENSION, V76, P101, DOI 10.1161/HYPERTENSIONAHA.120.14759
   Carpino G, 2020, HEPATOLOGY, V72, P470, DOI 10.1002/hep.31056
   Castro-Alves VC, 2018, INT J BIOL MACROMOL, V111, P1222, DOI 10.1016/j.ijbiomac.2018.01.131
   Cerón-Guevara MI, 2020, FOODS, V9, DOI 10.3390/foods9060760
   Chai WY, 2021, FUTURE FOODS, V4, DOI 10.1016/j.fufo.2021.100075
   Chambers Edward S, 2018, Curr Nutr Rep, V7, P198, DOI 10.1007/s13668-018-0248-8
   Chan SW, 2021, PHARM BIOL, V59, P1161, DOI 10.1080/13880209.2021.1969413
   Cheong KC, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2020-047849
   Chen CC, 2019, FOODS, V8, DOI 10.3390/foods8010030
   Cheng LX, 2019, PUBLIC HEALTH NUTR, V22, P2055, DOI 10.1017/S1368980019000247
   Cho CE, 2020, NUTRIENTS, V12, DOI 10.3390/nu12082220
   Cho SY, 2023, J FOOD PROCESS ENG, V46, DOI 10.1111/jfpe.14128
   Cortina-Escribano M, 2020, MOLECULES, V25, DOI 10.3390/molecules25204732
   da Costa PQ, 2021, J FUTURE FOODS, V1, P98, DOI 10.1016/j.jfutfo.2021.08.002
   Dable-Tupas G., 2020, Formulations and Innovations, P1
   Danadapat S., 2020, Turkish Journal of Agriculture-Food Science and Technology, V8, P2268, DOI 10.24925/turjaf.v8i11.2268-2276.2761
   Das S, 2021, J FOOD BIOCHEM, V45, DOI 10.1111/jfbc.13697
   Giraldo LRD, 2023, MICROORGANISMS, V11, DOI 10.3390/microorganisms11051158
   Desisa B, 2024, FUTURE FOODS, V9, DOI 10.1016/j.fufo.2024.100302
   Dicks L, 2022, EUR J NUTR, V61, P687, DOI 10.1007/s00394-021-02674-1
   Dimopoulou M, 2022, APPL SCI-BASEL, V12, DOI 10.3390/app12168074
   Dobrowolski P, 2022, ARTER HYPERTENS, V26, DOI [10.5603/AH.a2022.0012, 10.5114/aoms/152921]
   Du B, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20164032
   Dubey S, 2020, DIABET METAB SYND OB, V13, P3035, DOI 10.2147/DMSO.S265798
   Duran-aranguren Daniel David, 2021, Bioresource Technology Reports, V16, DOI 10.1016/j.biteb.2021.100849
   EGER G, 1976, THEOR APPL GENET, V47, P155, DOI 10.1007/BF00278373
   El Sheikha AF, 2022, FOODS, V11, DOI 10.3390/foods11071030
   El-Hadidy G. S., 2023, Asian Journal of Food Research and Nutrition, V2, P522
   Elhusseiny SM, 2021, MOLECULES, V26, DOI 10.3390/molecules26154623
   European Commission, 2006, Off. J. Eur. Union, DOI DOI 10.2203/DOSE-RESPONSE.06-012.HANEKAMP
   Fabiani R, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092056
   Fagenson AM, 2021, SURGERY, V169, P1054, DOI 10.1016/j.surg.2020.11.021
   Food and Agriculture Organization of the United Nations & World Health Organization, 2019, General standard for contaminants and toxins in food and feed, P50
   Gabrovska D., 2004, Czech Journal of Food Sciences, V22, P317
   Gallardo-Alfaro L, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041013
   Gao X, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00168
   Ge PX, 2023, J THROMB HAEMOST, V21, P117, DOI 10.1016/j.jtha.2022.10.010
   Gil-Ramírez A, 2016, J FUNCT FOODS, V25, P1, DOI 10.1016/j.jff.2016.05.005
   Golian M, 2022, FOODS, V11, DOI 10.3390/foods11010076
   González-Bonilla A, 2022, INT J MED MUSHROOMS, V24, P49, DOI 10.1615/IntJMedMushrooms.2022044837
   González-Ibáñez L, 2023, FOOD FUNCT, V14, P5048, DOI [10.1039/d3fo00089c, 10.1039/D3FO00089C]
   Gopala Krishnan U., 2019, Evaluation of agricultural and food wastes as alternative substrate components for cultivation of white oyster mushroom Pleurotus floridanus singer Universiti Malaya
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Han D, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-55507-x
   Han XY, 2023, J FUTURE FOODS, V3, P55, DOI 10.1016/j.jfutfo.2022.09.009
   Handayani D., 2012, Food and Nutrition Sciences, V3, P1009
   Harris G.K., 2017, Food Analysis, P287, DOI [10.1007/978-3-319-45776-516, DOI 10.1007/978-3-319-45776-516]
   Hassan AI, 2021, J GENET ENG BIOTECHN, V19, DOI 10.1186/s43141-021-00278-0
   Hemmati M, 2023, LIFE SCI, V329, DOI 10.1016/j.lfs.2023.121947
   Huang GL, 2021, PHYTOTHER RES, V35, P2890, DOI 10.1002/ptr.6995
   Huang JF, 2020, ACTA SCI POLON-TECHN, V19, P279, DOI [10.17306/J.AFS.0775, 10.17306/J.AFS.2020.0755]
   Ibrahim MS, 2020, INT J FOOD PROP, V23, P1373, DOI 10.1080/10942912.2020.1806297
   Igile GO., 2020, Eur J Food Sci Technol, V8, P46
   Ikewuchi J. C., 2014, Biomedicine & Preventive Nutrition, V4, P257
   Innayah AM, 2023, HEALTHC LOW-RESOUR S, V11, DOI 10.4081/hls.2023.11165
   Irshad A, 2023, BIOMED RES INT, V2023, DOI 10.1155/2023/8150909
   Iseki K, 2020, INTERNAL MED, V59, P2671, DOI 10.2169/internalmedicine.4975-20
   Ismail, 2017, Food Analysis Laboratory Manual, V3, P117, DOI DOI 10.1007/978-3-319-44127-6_11
   Jamar G, 2021, CRIT REV FOOD SCI, V61, P836, DOI 10.1080/10408398.2020.1747046
   James K., 2022, Current Developments in Nutrition, V6, P1113
   Jang JH, 2011, FOOD CHEM, V127, P412, DOI 10.1016/j.foodchem.2011.01.010
   Jin ZQ, 2020, J SCI FOOD AGR, V100, P4901, DOI 10.1002/jsfa.10551
   Jo J, 2009, PLOS COMPUT BIOL, V5, DOI 10.1371/journal.pcbi.1000324
   Jo KJ, 2019, J MED FOOD, V22, P178, DOI 10.1089/jmf.2018.4255
   Julibert A, 2019, NUTR METAB CARDIOVAS, V29, P887, DOI 10.1016/j.numecd.2019.05.055
   Kakoti M, 2021, POL J FOOD NUTR SCI, V71, P463, DOI 10.31883/pjfns/144044
   Kalaw SP, 2022, ASIAN J AGR BIOL, V10, DOI 10.35495/ajab.2021.05.233
   Kanagasabapathy G, 2014, FOOD CHEM, V145, P198, DOI 10.1016/j.foodchem.2013.08.051
   Kanagasabapathy G, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/185259
   Kawano Y, 2022, CELL, V185, P3501, DOI 10.1016/j.cell.2022.08.005
   Kleftaki SA, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11112113
   Kleftaki SA, 2022, PHARMACOL RES, V175, DOI 10.1016/j.phrs.2021.105979
   KLOTZSCH SG, 1990, CLIN CHEM, V36, P1605
   Kolawole FL, 2021, ANN U DUNAREA-FOOD, V45, P20, DOI 10.35219/foodtechnology.2021.2.02
   Kortei N. K., 2017, Food Science and Technology, V5, P9
   Krakowska A, 2020, FOOD CHEM, V327, DOI 10.1016/j.foodchem.2020.127084
   Krishna KV, 2023, J KING SAUD UNIV SCI, V35, DOI 10.1016/j.jksus.2023.102926
   Krishnamoorthi R, 2022, PROCESS BIOCHEM, V121, P10, DOI 10.1016/j.procbio.2022.06.021
   Lam V. N., 2022, International Journal of Agricultural Technology, V18, P231
   Lechner K, 2020, METAB SYNDR RELAT D, V18, P176, DOI 10.1089/met.2019.0115
   Lee Y-S., 2020, Korean J Health Promotion, V20, P116, DOI [10.15384/kjhp.2020.20.3.116, DOI 10.15384/KJHP.2020.20.3.116]
   Li LH, 2019, J FOOD DRUG ANAL, V27, P375, DOI 10.1016/j.jfda.2018.09.001
   Li L, 2023, J AGR FOOD CHEM, V71, P14838, DOI 10.1021/acs.jafc.3c02304
   Li MJ, 2022, FOOD CHEM, V395, DOI 10.1016/j.foodchem.2022.133581
   Li Q, 2019, FOOD FUNCT, V10, P7174, DOI 10.1039/c9fo01465a
   Li RR, 2022, SCI HORTIC-AMSTERDAM, V305, DOI 10.1016/j.scienta.2022.111416
   Li S, 2020, LIFE SCI, V259, DOI 10.1016/j.lfs.2020.118200
   Li WZ, 2023, JMIR PUBLIC HLTH SUR, V9, DOI 10.2196/44073
   Li XC, 2018, BRIT J NUTR, V120, P612, DOI 10.1017/S0007114518001496
   Li ZZ, 2022, CELL DEATH DISCOV, V8, DOI 10.1038/s41420-022-01200-4
   Liu PY, 2021, PHARMACOL RES, V165, DOI 10.1016/j.phrs.2021.105420
   Lyu Y. M., 2022, Grain Oil Science and Technology, V5, P35, DOI [10.1016/j.gaost.2021.12.002, DOI 10.1016/J.GAOST.2021.12.002]
   Macpherson ME, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.574500
   Maheshwari G, 2020, MOL NUTR FOOD RES, V64, DOI 10.1002/mnfr.202000591
   Maity P, 2021, INT J BIOL MACROMOL, V172, P408, DOI 10.1016/j.ijbiomac.2021.01.081
   Manthou E, 2019, LWT-FOOD SCI TECHNOL, V111, P506, DOI 10.1016/j.lwt.2019.05.062
   Martínez-Flores HE, 2021, J INORG ORGANOMET P, V31, P1406, DOI 10.1007/s10904-020-01820-2
   Mihai RA, 2022, J FUNGI, V8, DOI 10.3390/jof8030274
   Moorthi P, 2022, MALAY APPL BIOL, V51, P17, DOI 10.55230/mabjournal.v51i6.2325
   Munir S, 2023, S AFR J BOT, V163, P57, DOI 10.1016/j.sajb.2023.10.027
   Musieba F., 2013, American Journal of Food Technology, V8, P200, DOI 10.3923/ajft.2013.200.206
   Mutha RE, 2021, FUTUR J PHARM SCI, V7, DOI 10.1186/s43094-020-00161-8
   Muthangya M., 2019, Journal of Applied Life Sciences International, V20, P1
   Ndubuisi C., 2022, Journal of Biosciences and Medicines, V10, P201
   Neri-Numa IA, 2020, J FUNCT FOODS, V73, DOI 10.1016/j.jff.2020.104132
   Ng SH, 2017, FOOD CHEM, V227, P358, DOI 10.1016/j.foodchem.2017.01.108
   Noubiap JJ, 2022, DIABETES RES CLIN PR, V188, DOI 10.1016/j.diabres.2022.109924
   Nwoko M., 2018, Journal of Environmental Science and Public Health, V2, P210
   Nworu CS, 2015, PHARM BIOL, V53, P1555, DOI 10.3109/13880209.2014.991838
   Ogwo N., 2019, International Journal of Agriculture, Environment and Food Sciences, V3, P162
   Oka N. K. C., 2020, European Journal of Nutrition & Food Safety, V12, P147, DOI [10.9734/ejnfs/2020/v12i930296, DOI 10.9734/EJNFS/2020/V12I930296]
   Okobiebi B.O., 2019, J. Ind. Technol, V8, P1
   Olatunji-Ojo AM, 2020, ENVIRON SCI POLLUT R, V27, P19754, DOI 10.1007/s11356-020-08494-w
   Omale S, 2020, ADV PHARMACOL PHARM, V8, P41, DOI 10.13189/app.2020.080302
   Onuekwuzu IM, 2020, ENDOCR METAB IMMUNE, V20, P380, DOI 10.2174/1871530319666190809155506
   Onuekwuzu IM, 2019, ENDOCR METAB IMMUNE, V19, P1148, DOI 10.2174/1871530319666190206213843
   Oyetayo FL, 2020, J DIABETES METAB DIS, V19, P1139, DOI 10.1007/s40200-020-00615-z
   Pammer LM, 2021, J INTERN MED, V290, P1219, DOI 10.1111/joim.13355
   Paranagama I, 2022, J MICROB BIOTEC FOOD, V11, DOI 10.55251/jmbfs.4029
   Patel Shyam Kishor, 2019, Plant Archives, V19, P3327
   Pérez-Bassart Z, 2024, FOOD HYDROCOLLOID, V146, DOI 10.1016/j.foodhyd.2023.109308
   Pérez-Bassart Z, 2023, FOOD CHEM, V402, DOI 10.1016/j.foodchem.2022.134207
   Petersmann A, 2019, EXP CLIN ENDOCR DIAB, V127, pS1, DOI 10.1055/a-1018-9078
   Piskov S, 2020, FOODS, V9, DOI 10.3390/foods9020160
   Ponbhagavathi TRT, 2022, J ANIM PLANT SCI-PAK, V32, P1430, DOI 10.36899/JAPS.2022.5.0550
   Priyadarshni KC, 2022, INORG CHEM COMMUN, V142, DOI 10.1016/j.inoche.2022.109673
   Pukalski J, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11193052
   Puzari P., 2023, Rivista Italiana di Filosofia Analitica Junior, V14, P1487
   Rodrigues DMF, 2015, J FOOD SCI TECH MYS, V52, P6927, DOI 10.1007/s13197-015-1826-z
   Rong JC, 2021, AGRONOMY-BASEL, V11, DOI 10.3390/agronomy11061210
   Royse D.J., 2017, Current overview of mushroom production in the world. Edible and medicinal mushrooms: Technology and applications
   Rutigliano I, 2017, NUTRITION, V36, P1, DOI 10.1016/j.nut.2016.10.017
   Salami S., 2021, Nigerian Journal of Animal Science, V23, P157
   Salami S. A., 2021, Advances in Animal and Veterinary Sciences, V9, P1576
   Sandoval J, 2020, EUR RESPIR J, V56, DOI 10.1183/13993003.02416-2019
   Sari M, 2017, FOOD CHEM, V216, P45, DOI 10.1016/j.foodchem.2016.08.010
   Schoch CL, 2020, DATABASE-OXFORD, DOI 10.1093/database/baaa062
   Sheng Y, 2019, FOOD SCI NUTR, V7, P1295, DOI 10.1002/fsn3.962
   Singh Manjit, 2021, Mushroom Research, V30, P99, DOI 10.36036/MR.30.2.2021.119394
   Singh RP, 2020, FRONT CELL INFECT MI, V10, DOI 10.3389/fcimb.2020.00376
   Singh R, 2020, ENVIRON MONIT ASSESS, V192, DOI 10.1007/s10661-020-08249-7
   Singh U, 2020, LWT-FOOD SCI TECHNOL, V131, DOI 10.1016/j.lwt.2020.109665
   Sithole SC, 2022, J KING SAUD UNIV SCI, V34, DOI 10.1016/j.jksus.2021.101763
   [孙昂远 Sun Angyuan], 2020, [中华皮肤科杂志, Chinese Journa of Dermatology], V53, P360
   Sun G., 2014, Sensors & Transducers, V26, P35
   Sundborn G, 2019, OBESITY, V27, P879, DOI 10.1002/oby.22472
   Tack J, 2021, UNITED EUR GASTROENT, V9, P727, DOI 10.1002/ueg2.12097
   Tapia MS., 2020, WATER ACT FOODS FUND, P323, DOI [DOI 10.1002/9781118765982.CH14, 10.1002/9781118765982.ch14]
   Tarmizi NAKA, 2022, J MED FOOD, V25, P230, DOI 10.1089/jmf.2021.K.0121
   Tekin-Cakmak ZH, 2024, J FUNCT FOODS, V112, DOI 10.1016/j.jff.2023.105939
   Tesch GH, 2007, NEPHROLOGY, V12, P261, DOI 10.1111/j.1440-1797.2007.00796.x
   Theobald HE, 2006, NUTR BULL, V31, P8, DOI 10.1111/j.1467-3010.2006.00528.x
   Tulsawani R, 2020, INT J MED MUSHROOMS, V22, P547, DOI 10.1615/IntJMedMushrooms.2020035074
   Tung YT, 2020, CURR PHARM DESIGN, V26, P4970, DOI 10.2174/1381612826666200831151316
   Valappil G. P., 2021, Letters in Applied NanoBioScience, V10, P2107
   Vasques-Monteiro IML, 2021, NUTR RES, V91, P26, DOI 10.1016/j.nutres.2021.04.008
   Vilas P. M., 2020, Journal of Pharmacognosy and Phytochemistry, V9, P881
   Vishwakarma P., 2023, INNOSC Theranostics and Pharmacological Sciences, V6, P1
   Volman JJ, 2008, PHYSIOL BEHAV, V94, P276, DOI 10.1016/j.physbeh.2007.11.045
   Waluyo, 2018, AGRITECH, V38, P282, DOI 10.22146/agritech.30068
   Wang C, 2022, FOODS, V11, DOI 10.3390/foods11182881
   Wang SH, 2022, FOOD FUNCT, V13, P9734, DOI [10.1039/d2fo01552h, 10.1039/D2FO01552H]
   Wang X, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.859923
   Wang YM, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-06636-3
   Wunjuntuk K, 2022, J FOOD COMPOS ANAL, V105, DOI 10.1016/j.jfca.2021.104226
   Xiong MR, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700444
   Yadav D, 2021, FOOD RES INT, V148, DOI 10.1016/j.foodres.2021.110599
   Yamauchi M, 2019, J KING SAUD UNIV SCI, V31, P490, DOI 10.1016/j.jksus.2018.04.021
   Yang GD, 2022, CAN J PHYSIOL PHARM, V100, P61, DOI 10.1139/cjpp-2021-0421
   Ye LH, 2019, ELIFE, V8, DOI 10.7554/eLife.48479
   Yin CM, 2020, CARBOHYD POLYM, V250, DOI 10.1016/j.carbpol.2020.116942
   Yoo HU, 2020, FOOD CHEM, V308, DOI 10.1016/j.foodchem.2019.125670
   Yoo W, 2021, SCIENCE, V373, P813, DOI 10.1126/science.aba3683
   Yu HL, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1197983
   Yue ZH, 2022, J FUNGI, V8, DOI 10.3390/jof8121244
   Zhao J, 2020, DIABET METAB SYND OB, V13, P1575, DOI 10.2147/DMSO.S250699
   Zhao YY, 2020, RSC ADV, V10, P11918, DOI 10.1039/c9ra10991a
   Zhu FM, 2015, J FOOD COMPOS ANAL, V41, P165, DOI 10.1016/j.jfca.2015.01.019
NR 211
TC 4
Z9 4
U1 6
U2 16
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-4292
EI 2212-4306
J9 FOOD BIOSCI
JI Food Biosci.
PD OCT
PY 2024
VL 61
AR 104768
DI 10.1016/j.fbio.2024.104768
EA JUL 2024
PG 18
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA ZZ3O9
UT WOS:001279070800001
DA 2025-06-11
ER

PT J
AU Vidal-Cevallos, P
   Sorroza-Martinez, AP
   Chavez-Tapia, NC
   Uribe, M
   Montalvo-Jave, EE
   Nuno-Lambarri, N
AF Vidal-Cevallos, Paulina
   Sorroza-Martinez, Adriana P.
   Chavez-Tapia, Norberto C.
   Uribe, Misael
   Montalvo-Jave, Eduardo E.
   Nuno-Lambarri, Natalia
TI The Relationship between Pathogenesis and Possible Treatments for the
   MASLD-Cirrhosis Spectrum
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE metabolic syndrome; sedentarism; fibrosis; hepatic steatosis;
   steatohepatitis; diet
ID NONALCOHOLIC FATTY LIVER; MEDITERRANEAN DIET; HEPATIC STEATOSIS;
   PHYSICAL-ACTIVITY; AEROBIC EXERCISE; LOW-CARBOHYDRATE;
   CARDIOVASCULAR-DISEASE; AMERICAN ASSOCIATION; INSULIN-RESISTANCE;
   METABOLIC SYNDROME
AB Metabolic dysfunction-associated steatotic liver disease (MASLD) is a term that entails a broad spectrum of conditions that vary in severity. Its development is influenced by multiple factors such as environment, microbiome, comorbidities, and genetic factors. MASLD is closely related to metabolic syndrome as it is caused by an alteration in the metabolism of fatty acids due to the accumulation of lipids because of an imbalance between its absorption and elimination in the liver. Its progression to fibrosis is due to a constant flow of fatty acids through the mitochondria and the inability of the liver to slow down this metabolic load, which generates oxidative stress and lipid peroxidation, triggering cell death. The development and progression of MASLD are closely related to unhealthy lifestyle habits, and nutritional epigenetic and genetic mechanisms have also been implicated. Currently, lifestyle modification is the first-line treatment for MASLD and nonalcoholic steatohepatitis; weight loss of >= 10% produces resolution of steatohepatitis and fibrosis regression. In many patients, body weight reduction cannot be achieved; therefore, pharmacological treatment should be offered in particular populations.
C1 [Vidal-Cevallos, Paulina; Chavez-Tapia, Norberto C.; Uribe, Misael; Montalvo-Jave, Eduardo E.] Med Sur Clin & Fdn, Obes & Digest Dis Unit, Mexico City 14050, DF, Mexico.
   [Sorroza-Martinez, Adriana P.; Chavez-Tapia, Norberto C.; Nuno-Lambarri, Natalia] Med Sur Clin & Fdn, Translat Res Unit, Mexico City 14050, DF, Mexico.
   [Montalvo-Jave, Eduardo E.; Nuno-Lambarri, Natalia] Univ Nacl Autonoma Mexico, Fac Med, Dept Surg, Mexico City 04360, DF, Mexico.
   [Montalvo-Jave, Eduardo E.] Hosp Gen Mex Dr Eduardo Liceaga, Dept Surg, Hepatopancreatobiliary Clin, Mexico City 06720, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico
RP Nuno-Lambarri, N (corresponding author), Med Sur Clin & Fdn, Translat Res Unit, Mexico City 14050, DF, Mexico.; Nuno-Lambarri, N (corresponding author), Univ Nacl Autonoma Mexico, Fac Med, Dept Surg, Mexico City 04360, DF, Mexico.
EM paulina.vice@gmail.com; paola.sorrozamtz@gmail.com;
   nchavezt@medicasur.org.mx; muribe@medicasur.org.mx;
   montalvoeduardo@hotmail.com; nnunol@medicasur.org.mx
RI Nuño-Lámbarri, Natalia/KBD-4162-2024
OI Chavez-Tapia, Norberto/0000-0002-7451-3306
FU Medica Sur Clinic and Foundation
FX We thank the Medica Sur Clinic and Foundation for their support in
   preparing this manuscript and BioRender.com for their support in
   creating the figures.
CR Abdelbasset WK, 2019, MEDICINE, V98, DOI [10.1097/MD.0000000000014918, 10.1097/md.0000000000014918]
   Abul-Husn NS, 2018, NEW ENGL J MED, V378, P1096, DOI 10.1056/NEJMoa1712191
   American Gastroenterological Association, 2002, Gastroenterology, V123, P1702
   Anania C, 2018, WORLD J GASTROENTERO, V24, P2083, DOI 10.3748/wjg.v24.i19.2083
   Anton SD, 2018, OBESITY, V26, P254, DOI 10.1002/oby.22065
   Argo CK, 2018, ALIMENT PHARM THER, V48, P290, DOI 10.1111/apt.14803
   Ballestri S, 2016, J GASTROEN HEPATOL, V31, P936, DOI 10.1111/jgh.13264
   Berná G, 2020, LIVER INT, V40, P102, DOI 10.1111/liv.14360
   Duarte SMB, 2014, NUTR HOSP, V29, P94
   Botello-Manilla AE, 2020, EXPERT REV GASTROENT, V14, P733, DOI 10.1080/17474124.2020.1780915
   Browning JD, 2011, AM J CLIN NUTR, V93, P1048, DOI 10.3945/ajcn.110.007674
   Bruschi FV, 2017, HEPATOLOGY, V65, P1875, DOI 10.1002/hep.29041
   Buchwald H, 2004, JAMA-J AM MED ASSOC, V292, P1724, DOI 10.1001/jama.292.14.1724
   Bugianesi E, 2005, DIABETOLOGIA, V48, P634, DOI 10.1007/s00125-005-1682-x
   Cantero I, 2018, CLIN NUTR, V37, P1736, DOI 10.1016/j.clnu.2017.06.027
   Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI 10.1002/hep.29367
   Chalasani N, 2012, HEPATOLOGY, V55, P2005, DOI 10.1002/hep.25762
   Chan WK, 2023, J OBES METAB SYNDR, V32, P197, DOI 10.7570/jomes23052
   Chen HW, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16122192
   Chen L, 2024, J HEPATOL, V80, pe64, DOI 10.1016/j.jhep.2023.08.021
   Chen YP, 2019, CLIN NUTR, V38, P2552, DOI 10.1016/j.clnu.2018.11.030
   Chen Z, 2020, FREE RADICAL BIO MED, V152, P116, DOI 10.1016/j.freeradbiomed.2020.02.025
   Cheng SL, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-16159-x
   Cohen JC, 2011, SCIENCE, V332, P1519, DOI 10.1126/science.1204265
   da Silva RP, 2014, BIOFACTORS, V40, P277, DOI 10.1002/biof.1154
   Davies KAB, 2019, MED SCI SPORT EXER, V51, P1169, DOI 10.1249/MSS.0000000000001901
   de Cabo R, 2019, NEW ENGL J MED, V381, P2541, DOI 10.1056/NEJMra1905136
   De Chiara F, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122985
   Del Campo JA, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19030911
   Donati B, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-04991-0
   Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI23621
   Dowla S, 2018, CONTEMP CLIN TRIALS, V68, P95, DOI 10.1016/j.cct.2018.03.014
   Drinda S, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112601
   Dunstan DW, 2005, DIABETOLOGIA, V48, P2254, DOI 10.1007/s00125-005-1963-4
   EASL, 2016, OBESITY FACTS, V9, P65, DOI [10.1159/000443344, 10.1007/s00125-016-3902-y, 10.1016/j.jhep.2015.11.004]
   Eguchi Y, 2015, HEPATOL RES, V45, P269, DOI 10.1111/hepr.12351
   Farzanegi P, 2019, EUR J SPORT SCI, V19, P994, DOI 10.1080/17461391.2019.1571114
   Ferenci P, 2019, JHEP REP, V1, P3, DOI 10.1016/j.jhepr.2019.02.007
   Ferolla SM, 2013, CLINICS, V68, P11
   Frassetto LA, 2009, EUR J CLIN NUTR, V63, P947, DOI 10.1038/ejcn.2009.4
   Friedman SL, 2018, NAT MED, V24, P908, DOI 10.1038/s41591-018-0104-9
   Fuglsang-Nielsen R, 2021, EUR J CLIN NUTR, V75, P611, DOI 10.1038/s41430-020-00759-4
   Garbow JR, 2011, AM J PHYSIOL-GASTR L, V300, pG956, DOI 10.1152/ajpgi.00539.2010
   Gelli C, 2017, WORLD J GASTROENTERO, V23, P3150, DOI 10.3748/wjg.v23.i17.3150
   Gerhard GS, 2018, CLIN EPIGENETICS, V10, DOI 10.1186/s13148-018-0525-9
   Gomez-Arbelaez D, 2017, J CLIN ENDOCR METAB, V102, P488, DOI 10.1210/jc.2016-2385
   Hallsworth K, 2015, FRONTLINE GASTROENTE, V6, P44, DOI 10.1136/flgastro-2014-100432
   Harrison SA, 2024, NEW ENGL J MED, V390, P497, DOI 10.1056/NEJMoa2309000
   Haufe S, 2011, HEPATOLOGY, V53, P1504, DOI 10.1002/hep.24242
   Heath RB, 2003, J LIPID RES, V44, P2065, DOI 10.1194/jlr.M300167-JLR200
   Pirola CJ, 2013, GUT, V62, P1356, DOI 10.1136/gutjnl-2012-302962
   Kabisch S, 2018, NUTRIENTS, V10, DOI 10.3390/nu10020157
   Katsagoni CN, 2018, BRIT J NUTR, V120, P164, DOI [10.1017/S000711451800137X, 10.1017/s000711451800137x]
   Keating SE, 2015, J HEPATOL, V63, P174, DOI 10.1016/j.jhep.2015.02.022
   Kennedy AR, 2007, AM J PHYSIOL-ENDOC M, V292, pE1724, DOI 10.1152/ajpendo.00717.2006
   Kim DH, 2019, AGING-US, V11, P4125, DOI 10.18632/aging.102042
   Kontogianni MD, 2014, CLIN NUTR, V33, P678, DOI 10.1016/j.clnu.2013.08.014
   Lange NF, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23084305
   Lassailly G, 2020, GASTROENTEROLOGY, V159, P1290, DOI 10.1053/j.gastro.2020.06.006
   Laursen TL, 2019, WORLD J HEPATOL, V11, P138, DOI 10.4254/wjh.v11.i2.138
   Lee J, 2017, MOL ASPECTS MED, V54, P78, DOI 10.1016/j.mam.2016.11.008
   Linden AG, 2018, J LIPID RES, V59, P475, DOI 10.1194/jlr.M081836
   Liu YL, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms5309
   Loomba R, 2015, GASTROENTEROLOGY, V149, P1784, DOI 10.1053/j.gastro.2015.08.011
   Luukkonen PK, 2018, DIABETES CARE, V41, P1732, DOI 10.2337/dc18-0071
   Maciejewska-Markiewicz D, 2022, NUTRIENTS, V14, DOI 10.3390/nu14204310
   Magalhaes GCB, 2014, J HUM NUTR DIET, V27, P301, DOI 10.1111/jhn.12110
   Mahdessian H, 2014, P NATL ACAD SCI USA, V111, P8913, DOI 10.1073/pnas.1323785111
   Mancina RM, 2016, GASTROENTEROLOGY, V150, P1219, DOI 10.1053/j.gastro.2016.01.032
   Mansour A, 2021, NUTR J, V20, DOI 10.1186/s12937-021-00694-5
   Marinho TD, 2019, NUTRITION, V65, P103, DOI 10.1016/j.nut.2019.02.020
   Markova M, 2017, GASTROENTEROLOGY, V152, P571, DOI 10.1053/j.gastro.2016.10.007
   Mathurin P, 2006, GASTROENTEROLOGY, V130, P1617, DOI 10.1053/j.gastro.2006.02.024
   McCarthy EM, 2012, J ACAD NUTR DIET, V112, P401, DOI 10.1016/j.jada.2011.10.007
   McPherson S, 2015, J HEPATOL, V62, P1148, DOI 10.1016/j.jhep.2014.11.034
   Meira ID, 2019, FRONT NEUROSCI-SWITZ, V13, DOI 10.3389/fnins.2019.00005
   Monda V, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21093228
   Morrison MC, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00132
   Mundi MS, 2020, NUTR CLIN PRACT, V35, P72, DOI 10.1002/ncp.10449
   Muscogiuri G, 2021, OBESITY FACTS, V14, P222, DOI 10.1159/000515381
   Musso G, 2012, DIABETOLOGIA, V55, P885, DOI 10.1007/s00125-011-2446-4
   Naguib G, 2020, LIVER INT, V40, P590, DOI 10.1111/liv.14309
   Nassir F, 2022, BIOMOLECULES, V12, DOI 10.3390/biom12060824
   O'Gorman P, 2019, J HEPATOL, V70, pE67, DOI 10.1016/S0618-8278(19)30117-3
   Oni ET, 2013, ATHEROSCLEROSIS, V230, P258, DOI 10.1016/j.atherosclerosis.2013.07.052
   Otten J, 2016, INT J OBESITY, V40, P747, DOI 10.1038/ijo.2016.4
   Pagano G, 2002, HEPATOLOGY, V35, P367, DOI 10.1053/jhep.2002.30690
   Paoli A, 2019, GENES-BASEL, V10, DOI 10.3390/genes10070534
   Parker HM, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020475
   Parthasarathy G, 2020, HEPATOL COMMUN, V4, P478, DOI 10.1002/hep4.1479
   Petta S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0087523
   Pettinelli P, 2011, J CLIN ENDOCR METAB, V96, P1424, DOI 10.1210/jc.2010-2129
   Pirola CJ, 2022, EXPERT REV GASTROENT, V16, P521, DOI 10.1080/17474124.2020.1765772
   Plauth M, 2019, CLIN NUTR, V38, P485, DOI 10.1016/j.clnu.2018.12.022
   Promrat K, 2010, HEPATOLOGY, V51, P121, DOI 10.1002/hep.23276
   Purushotham A, 2009, CELL METAB, V9, P327, DOI 10.1016/j.cmet.2009.02.006
   Qian L, 2024, SIGNAL TRANSDUCT TAR, V9, DOI 10.1038/s41392-024-01756-w
   Rinella ME, 2023, HEPATOLOGY, V77, P1797, DOI 10.1097/HEP.0000000000000323
   Rinella ME, 2023, J HEPATOL, V79, P1542, DOI 10.1016/j.jhep.2023.06.003
   Romeo S, 2008, NAT GENET, V40, P1461, DOI 10.1038/ng.257
   Rong L, 2023, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.1087260
   Schneider CV, 2024, ALIMENT PHARM THER, V59, P1271, DOI 10.1111/apt.17958
   Schugar RC, 2012, CURR OPIN CLIN NUTR, V15, P374, DOI 10.1097/MCO.0b013e3283547157
   Shah SA, 2021, EUR J NUTR, V60, P3935, DOI 10.1007/s00394-021-02565-5
   Softic S, 2016, DIGEST DIS SCI, V61, P1282, DOI 10.1007/s10620-016-4054-0
   Sohouli MH, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.934845
   Sookoian S, 2017, CLIN MOL HEPATOL, V23, P1, DOI 10.3350/cmh.2016.0109
   Sookoian S, 2016, SCI REP-UK, V6, DOI 10.1038/srep27718
   Speliotes EK, 2010, HEPATOLOGY, V51, P1979, DOI 10.1002/hep.23593
   Staufer K, 2023, BIOMEDICINES, V11, DOI 10.3390/biomedicines11082108
   Stekovic S, 2019, CELL METAB, V30, P462, DOI 10.1016/j.cmet.2019.07.016
   Stender S, 2017, NAT GENET, V49, P842, DOI 10.1038/ng.3855
   Stern JH, 2016, CELL METAB, V23, P770, DOI 10.1016/j.cmet.2016.04.011
   Sumida Y, 2018, J GASTROENTEROL, V53, P362, DOI 10.1007/s00535-017-1415-1
   Tanwar S, 2020, WORLD J GASTROENTERO, V26, P109, DOI 10.3748/wjg.v26.i2.109
   Targher G, 2016, J HEPATOL, V65, P589, DOI 10.1016/j.jhep.2016.05.013
   Tendler D, 2007, DIGEST DIS SCI, V52, P589, DOI 10.1007/s10620-006-9433-5
   ter Horst KW, 2017, NUTRIENTS, V9, DOI 10.3390/nu9090981
   Torres MCP, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122971
   Tryndyak VP, 2011, MOL NUTR FOOD RES, V55, P411, DOI 10.1002/mnfr.201000300
   Valenti L, 2010, HEPATOLOGY, V51, P1209, DOI 10.1002/hep.23622
   Van Dalem J, 2021, HEPATOLOGY, V74, P2467, DOI 10.1002/hep.32012
   van der Windt Dirk J., 2018, Gene Expression-The Journal of Liver Research, V18, P89, DOI 10.3727/105221617X15124844266408
   Varkaneh HK, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.948655
   Vilar-Gomez E, 2015, GASTROENTEROLOGY, V149, P367, DOI 10.1053/j.gastro.2015.04.005
   Wang D, 2006, ENDOCRINOLOGY, V147, P943, DOI 10.1210/en.2005-0570
   Wang ST, 2020, BMC GASTROENTEROL, V20, DOI 10.1186/s12876-020-01204-3
   Watanabe M, 2020, OBES REV, V21, DOI 10.1111/obr.13024
   Wijarnpreecha K, 2016, QJM-INT J MED, V109, P461, DOI 10.1093/qjmed/hcv172
   Wong VWS, 2018, J HEPATOL, V69, P1349, DOI 10.1016/j.jhep.2018.08.011
   Xu CC, 2020, LIVER INT, V40, P2982, DOI 10.1111/liv.14596
   Zain SM, 2015, J GASTROEN HEPATOL, V30, P21, DOI 10.1111/jgh.12714
   Zelber-Sagil S, 2007, J HEPATOL, V47, P711, DOI 10.1016/j.jhep.2007.06.020
   Zhang CY, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22147571
   Zhou R, 2021, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.600175
NR 135
TC 8
Z9 8
U1 1
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2024
VL 25
IS 8
AR 4397
DI 10.3390/ijms25084397
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA QJ3J0
UT WOS:001220464800001
PM 38673981
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhou, MT
   Hu, NH
   Liu, MC
   Deng, Y
   He, LF
   Guo, CC
   Zhao, XT
   Li, YX
AF Zhou, Mengting
   Hu, Naihua
   Liu, Meichen
   Deng, Ying
   He, Linfeng
   Guo, Chaocheng
   Zhao, Xingtao
   Li, Yunxia
TI A Candidate Drug for Nonalcoholic Fatty Liver Disease: A Review of
   Pharmacological Activities of Polygoni Multiflori Radix
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Review
ID NF-KAPPA-B; OXIDATIVE STRESS; HEPATIC STEATOSIS; GUT MICROBIOTA;
   STILBENE GLUCOSIDE; FREE-RADICALS; MOUSE MODEL; IN-VITRO; RESVERATROL;
   EMODIN
AB Nonalcoholic fatty liver disease, a type of metabolic syndrome, continues to rise globally. Currently, there is no approved drug for its treatment. Improving lifestyle and exercise can alleviate symptoms, but patients' compliance is poor. More and more studies have shown the potential of Polygoni Multiflori Radix (PMR) in the treatment of NAFLD and metabolic syndrome. Therefore, this paper reviews the pharmacological effects of PMR and its main chemical components (tetrahydroxystilbene glucoside, emodin, and resveratrol) on NAFLD. PMR can inhibit the production of fatty acids and promote the decomposition of triglycerides, reduce inflammation, and inhibit the occurrence of liver fibrosis. At the same time, it maintains an oxidation equilibrium status in the body, to achieve the therapeutic purpose of NAFLD and metabolic syndrome. Although more standardized studies and clinical trials are needed to confirm its efficacy, PMR may be a potential drug for the treatment of NAFLD and its complications. However, the occurrence of adverse reactions of PMR has affected its extensive clinical application. Therefore, it is necessary to further study its toxicity mechanism, enhance efficacy and control toxicity, and even reduce toxicity, which will contribute to the safe clinical use of PMR.
C1 [Zhou, Mengting; Hu, Naihua; Liu, Meichen; Deng, Ying; He, Linfeng; Guo, Chaocheng; Zhao, Xingtao; Li, Yunxia] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China.
   [Zhou, Mengting; Hu, Naihua; Liu, Meichen; Deng, Ying; He, Linfeng; Guo, Chaocheng; Zhao, Xingtao; Li, Yunxia] Minist Educ, Key Lab Standardizat Chinese Herbal Med, Chengdu 611137, Peoples R China.
   [Zhou, Mengting; Hu, Naihua; Liu, Meichen; Deng, Ying; He, Linfeng; Guo, Chaocheng; Zhao, Xingtao; Li, Yunxia] Natl Key Lab Breeding Base Systemat Res Dev & Uti, Chengdu 611137, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Ministry of
   Education - China
RP Li, YX (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China.; Li, YX (corresponding author), Minist Educ, Key Lab Standardizat Chinese Herbal Med, Chengdu 611137, Peoples R China.; Li, YX (corresponding author), Natl Key Lab Breeding Base Systemat Res Dev & Uti, Chengdu 611137, Peoples R China.
EM 760804167@qq.com; 364673561@qq.com; 245982034@qq.com; 1187979146@qq.com;
   623037768@qq.com; 1109261310@qq.com; 1806016946@qq.com;
   lyxcdutcm@126.com
RI Zhou, Mengting/ITU-0911-2023; zhao, xingtao/MCK-2881-2025; naihua,
   hu/GVU-8621-2022
OI Deng, Ying/0000-0003-1742-1197; zhao, xingtao/0000-0003-1668-0453; li,
   yunxia/0000-0003-1307-4335; He, Linfeng/0000-0001-7211-1170; Zhou,
   Mengting/0000-0002-2707-4902; Guo, Chaocheng/0000-0002-9490-1365; hu,
   naihua/0000-0002-9164-8827
FU National Natural Science Foundation of China (NSFC) [81373943,
   81573583]; Sichuan Provincial Science and Technology Department of Youth
   Science and Technology Innovation Research Team Program [2017TD0001]
FX The work was supported by the National Natural Science Foundation of
   China (NSFC) (Grant Nos. 81373943 and 81573583) and the Sichuan
   Provincial Science and Technology Department of Youth Science and
   Technology Innovation Research Team Program (2017TD0001).
CR Ahmad O, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20081984
   Alisi A, 2012, INT J MOL SCI, V13, P2276, DOI 10.3390/ijms13022276
   [Anonymous], CHINA PHARM
   Battinelli L, 2004, ANN INTERN MED, V140, pE589, DOI 10.7326/0003-4819-140-7-200404060-00042-w3
   Berlanga A, 2014, CLIN EXP GASTROENTER, V7, P221, DOI 10.2147/CEG.S62831
   Bounda GA, 2015, PHARMACOGN RES, V7, P225, DOI 10.4103/0974-8490.157957
   Bugianesi E, 2005, AM J GASTROENTEROL, V100, P1082, DOI 10.1111/j.1572-0241.2005.41583.x
   Buzzetti E, 2016, METABOLISM, V65, P1038, DOI 10.1016/j.metabol.2015.12.012
   Carpentier Y, 1999, Rev Med Brux, V20, P427
   Chang YX, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/5965067
   Chen HF, 2016, CHIN MED-UK, V11, DOI 10.1186/s13020-016-0087-8
   Chen JX, 2011, J ETHNOPHARMACOL, V134, P919, DOI 10.1016/j.jep.2011.01.048
   Chen XX, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00434
   Chen XM, 2018, CAN J PHYSIOL PHARM, V96, P8, DOI 10.1139/cjpp-2017-0474
   Chen ZK, 2019, LIPIDS HEALTH DIS, V18, DOI 10.1186/s12944-019-1104-6
   Cheng K, 2019, MED MOL MORPHOL, V52, P187, DOI 10.1007/s00795-019-00216-7
   Chistiakov DA, 2016, J CELL MOL MED, V20, P17, DOI 10.1111/jcmm.12689
   Chiu PY, 2002, PLANTA MED, V68, P951, DOI 10.1055/s-2002-35661
   Choi RY, 2018, BIOMED PHARMACOTHER, V106, P355, DOI 10.1016/j.biopha.2018.06.140
   Chong CM, 2019, CHIN MED-UK, V14, DOI 10.1186/s13020-019-0242-0
   Cicero AFG, 2018, NUTRIENTS, V10, DOI 10.3390/nu10091153
   Compare D, 2012, NUTR METAB CARDIOVAS, V22, P471, DOI 10.1016/j.numecd.2012.02.007
   Cui H., 2020, J PEDIATR ENDOCR MET, DOI [10.1001/jama.2020.2298, DOI 10.1001/JAMA.2020.2298]
   Carvalho MMD, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-44563-y
   Dembowski E, 2009, J CARDIOPULM REHABIL, V29, P2, DOI 10.1097/HCR.0b013e318192754e
   DiDonato JA, 2012, IMMUNOL REV, V246, P379, DOI 10.1111/j.1600-065X.2012.01099.x
   Dong H, 2005, WORLD J GASTROENTERO, V11, P1339, DOI 10.3748/wjg.v11.i9.1339
   Dong XX, 2016, PHYTOTHER RES, V30, P1207, DOI 10.1002/ptr.5631
   Drew L, 2017, NATURE, V551, pS86, DOI 10.1038/d41586-017-06926-1
   Duan YT, 2019, LIFE SCI, V232, DOI 10.1016/j.lfs.2019.116638
   Faghihzadeh F, 2014, NUTR RES, V34, P837, DOI 10.1016/j.nutres.2014.09.005
   Fang YZ, 2002, NUTRITION, V18, P872, DOI 10.1016/S0899-9007(02)00916-4
   Ford RJ, 2015, BIOCHEM J, V468, P125, DOI 10.1042/BJ20150125
   Gao Xuan, 2007, Zhongguo Zhong Yao Za Zhi, V32, P323
   Gong LL, 2020, LIFE SCI, V242, DOI 10.1016/j.lfs.2019.117212
   Hajighasem A, 2018, PEERJ, V6, DOI 10.7717/peerj.5522
   Hanefeld M, 2002, DIABETES OBES METAB, V4, P415, DOI 10.1046/j.1463-1326.2002.00237.x
   He XY, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17030300
   Hei ZQ, 2006, CHINESE MED J-PEKING, V119, P868, DOI 10.1097/00029330-200605020-00012
   Hosseini H, 2020, INT J BIOCHEM CELL B, V119, DOI 10.1016/j.biocel.2019.105667
   Hu XL, 2019, PLANTA MED, V85, P678, DOI 10.1055/a-0895-5838
   Huang CH, 2007, J ETHNOPHARMACOL, V114, P199, DOI 10.1016/j.jep.2007.07.034
   Huang J, 2018, CHIN J NAT MEDICINES, V16, P375, DOI 10.1016/S1875-5364(18)30070-0
   Huang TH, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20102558
   Huang YJ, 2020, APPL PHYSIOL NUTR ME, V45, P227, DOI 10.1139/apnm-2019-0057
   Ipsen DH, 2018, CELL MOL LIFE SCI, V75, P3313, DOI 10.1007/s00018-018-2860-6
   Izdebska M, 2018, J PHARM PHARM SCI, V21, P504, DOI 10.18433/jpps29994
   Izdebska M, 2017, CAN J PHYSIOL PHARM, V95, P1442, DOI 10.1139/cjpp-2016-0561
   Ji Guang Ji Guang, 2014, Journal of Clinical Hepatology, V30, P299
   Jia XM, 2014, EXP BIOL MED, V239, P1025, DOI 10.1177/1535370214530247
   Jiang Z, 2017, MOL MED REP, V16, P5219, DOI 10.3892/mmr.2017.7225
   Jiao CL, 2017, BIOMED PHARMACOTHER, V96, P222, DOI 10.1016/j.biopha.2017.09.134
   Jin W., 2004, STUDIES ZHIHESHOUWU
   Kamari Y, 2011, J HEPATOL, V55, P1086, DOI 10.1016/j.jhep.2011.01.048
   Kessoku T, 2016, SCI REP-UK, V6, DOI 10.1038/srep22251
   Khaleel EF, 2018, CAN J PHYSIOL PHARM, V96, P145, DOI 10.1139/cjpp-2017-0001
   Khoury T, 2019, EUR J GASTROEN HEPAT, V31, P1110, DOI 10.1097/MEG.0000000000001393
   Kim HN, 2013, J ETHNOPHARMACOL, V150, P108, DOI 10.1016/j.jep.2013.08.014
   Kohjima M, 2007, INT J MOL MED, V20, P351
   Lee BH, 2012, PHARM BIOL, V50, P351, DOI 10.3109/13880209.2011.604335
   Lei X, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/459749
   Li CY, 2016, FRONT PHARMACOL, V7, DOI [10.3389/faphr.2016.00483, 10.3389/fphar.2016.00483]
   Li Chun-yu, 2015, Yaoxue Xuebao, V50, P28
   Li CL, 2012, J PHARMACEUT BIOMED, V71, P71, DOI 10.1016/j.jpba.2012.07.031
   Li FJ, 2020, J ETHNOPHARMACOL, V247, DOI 10.1016/j.jep.2019.112232
   Li HL, 2017, FOOD CHEM TOXICOL, V108, P407, DOI 10.1016/j.fct.2016.07.035
   Li L, 2014, FOOD CHEM TOXICOL, V63, P166, DOI 10.1016/j.fct.2013.08.036
   [李丽春 Li Lichun], 2003, [中国生物化学与分子生物学报, Chinese Journal of Biochemistry and Molecular Biology], V19, P297
   Li N, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/329171
   Li S, 2015, INT J MOL SCI, V16, P26087, DOI 10.3390/ijms161125942
   Li XJ, 2016, HEPATOL RES, V46, pE105, DOI 10.1111/hepr.12538
   Lin EY, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/4130307
   Lin L, 2020, J ETHNOPHARMACOL, V252, DOI 10.1016/j.jep.2020.112577
   Lin LF, 2015, J ETHNOPHARMACOL, V159, P158, DOI 10.1016/j.jep.2014.11.009
   Lin P, 2017, PHARMACOGN MAG, V13, P245, DOI 10.4103/0973-1296.204563
   Lin P, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/642058
   Liu C, 1992, Zhongguo Zhong Yao Za Zhi, V17, P595
   Liu F, 2018, MOL MED REP, V18, P3262, DOI 10.3892/mmr.2018.9324
   Liu Qian, 2015, Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, V31, P620
   Liu T., 2016, EFFECT EMODIN INHIBI, V27, P201
   Liu Y, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00364
   Ma J, 2015, J ETHNOPHARMACOL, V162, P61, DOI 10.1016/j.jep.2014.12.045
   Ma JL, 2017, NUTRIENTS, V9, DOI 10.3390/nu9101124
   Ma M J, 2017, Zhonghua Gan Zang Bing Za Zhi, V25, P789, DOI 10.3760/cma.j.issn.1007-3418.2017.10.017
   Escudé AM, 2020, MED CLIN-BARCELONA, V154, P1, DOI 10.1016/j.medcli.2019.03.018
   McOrist AL, 2008, BRIT J NUTR, V100, P138, DOI 10.1017/S0007114507886351
   McPherson S, 2015, J HEPATOL, V62, P1148, DOI 10.1016/j.jhep.2014.11.034
   Mohseni R, 2019, IMMUNOPHARM IMMUNOT, V41, P644, DOI 10.1080/08923973.2019.1688829
   National Pharmacopoeia Committee, 2015, Pharmacopoeia of the Peoples Republic of China (2015 edition)
   Neuschwander-Tetri BA, 2003, HEPATOLOGY, V37, P1202, DOI 10.1053/jhep.2003.50193
   Nishitsuji K, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-16189-5
   Andrade JMO, 2014, NUTRITION, V30, P915, DOI 10.1016/j.nut.2013.11.016
   Pandak WM, 2001, AM J PHYSIOL-GASTR L, V281, pG878, DOI 10.1152/ajpgi.2001.281.4.G878
   Panis B, 2005, J PEDIATR GASTR NUTR, V41, P256, DOI 10.1097/01.MPG.0000164699.41282.67
   Pastori D, 2015, DIGEST LIVER DIS, V47, P4, DOI 10.1016/j.dld.2014.07.170
   Peng C, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/831841
   Pierantonelli I, 2019, TRANSPLANTATION, V103, pe1, DOI 10.1097/TP.0000000000002480
   Pinçon A, 2019, METABOLITES, V9, DOI 10.3390/metabo9050104
   Q B., 2018, PHARM MET EV ALL INS
   Q X., 2020, CHINESE ARCH TRADITI, V38, P162
   Raskovic A, 2019, SAUDI PHARM J, V27, P1036, DOI 10.1016/j.jsps.2019.08.006
   Salva-Pastor N, 2019, J STEROID BIOCHEM, V194, DOI 10.1016/j.jsbmb.2019.105445
   Sánchez-Valle V, 2012, CURR MED CHEM, V19, P4850, DOI 10.2174/092986712803341520
   Schuster DP, 2010, DIABETES METAB SYNDR, V3, P253, DOI 10.2147/DMSO.S7354
   Sharma BR, 2017, NUTR RES, V47, P44, DOI 10.1016/j.nutres.2017.09.002
   Sheka AC, 2020, JAMA-J AM MED ASSOC, V323, P1175, DOI 10.1001/jama.2020.2298
   Shen J, 2013, MOL ASPECTS MED, V34, P39, DOI 10.1016/j.mam.2012.11.001
   Shrimali D, 2013, CANCER LETT, V341, P139, DOI 10.1016/j.canlet.2013.08.023
   Sumida Y, 2013, FREE RADICAL RES, V47, P869, DOI 10.3109/10715762.2013.837577
   Sun YN, 2016, PHARMACOGN MAG, V12, P31, DOI 10.4103/0973-1296.176019
   Szczepaniak LS, 2005, AM J PHYSIOL-ENDOC M, V288, pE462, DOI 10.1152/ajpendo.00064.2004
   Tandra S, 2011, J HEPATOL, V55, P654, DOI 10.1016/j.jhep.2010.11.021
   Ho TT, 2019, APPL MICROBIOL BIOT, V103, P3317, DOI 10.1007/s00253-019-09709-y
   Theodotou M, 2019, EXP THER MED, V18, P559, DOI 10.3892/etm.2019.7607
   Tian YL, 2016, MOL CELL BIOCHEM, V422, P75, DOI 10.1007/s11010-016-2807-x
   Trela BC, 1996, J AGR FOOD CHEM, V44, P1253, DOI 10.1021/jf9504576
   Tzifi F, 2019, HORM-INT J ENDOCRINO, V18, P255, DOI 10.1007/s42000-019-00107-7
   Tziomalos K, 2015, METABOLISM, V64, P1215, DOI 10.1016/j.metabol.2015.07.003
   Velasco JAVR, 2019, REV GASTROENTEROL ME, V84, P472, DOI 10.1016/j.rgmx.2019.05.004
   Walker AB, 1998, DIABETES, V47, P810, DOI 10.2337/diabetes.47.5.810
   Wan S, 2019, ROY SOC OPEN SCI, V6, DOI 10.1098/rsos.182173
   Wan SQ, 2018, ROY SOC OPEN SCI, V5, DOI 10.1098/rsos.181457
   [王春英 WANG chunying], 2008, [中草药, Chinese Traditional and Herbal Drugs], V39, P78
   [王浩 Wang Hao], 2019, [中国实验方剂学杂志, Chinese Journal of Experimental Traditional Medical Formulae], V25, P192
   Wang MJ, 2012, J ETHNOPHARMACOL, V139, P287, DOI 10.1016/j.jep.2011.11.022
   Wang SJ, 2017, HEPATOL RES, V47, P683, DOI 10.1111/hepr.12788
   Wang WE, 2014, J ETHNOPHARMACOL, V153, P763, DOI 10.1016/j.jep.2014.03.042
   Wang XL, 2018, PHYTOTHER RES, V32, P2436, DOI 10.1002/ptr.6182
   Wang Y, 2017, J GLOB ANTIMICROB RE, V9, P19, DOI 10.1016/j.jgar.2017.02.005
   Wang YH, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/8216714
   Wei WT, 2013, ONCOL REP, V30, P2555, DOI 10.3892/or.2013.2741
   Weinstein G, 2019, LIVER INT, V39, P1713, DOI 10.1111/liv.14161
   Wu LY, 2014, METABOLISM, V63, P1469, DOI 10.1016/j.metabol.2014.08.010
   X L., 2006, ZHEJIANG J TRADITION, V10, P588
   X W., 2006, J ANHUI U CHINESE ME, V5, P39
   Xian Z, 2017, BIOL PHARM BULL, V40, P1839, DOI 10.1248/bpb.b17-00218
   Xu J, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20071617
   Yang JB, 2018, BIOMED PHARMACOTHER, V99, P205, DOI 10.1016/j.biopha.2018.01.033
   Yang JQ, 2019, LIPIDS HEALTH DIS, V18, DOI 10.1186/s12944-019-1055-y
   Yin J H, 1992, Zhongguo Zhong Yao Za Zhi, V17, P722
   Yu J, 2011, J ETHNOPHARMACOL, V137, P1291, DOI 10.1016/j.jep.2011.07.055
   [余琳媛 Yu Linyuan], 2020, [中国实验方剂学杂志, Chinese Journal of Experimental Traditional Medical Formulae], V26, P203
   Z W., 2000, CHINESE TRADITIONAL, V12, P28
   Zelber-Sagi S, 2012, J HEPATOL, V56, P1145, DOI 10.1016/j.jhep.2011.12.011
   Zhang W, 2008, CLIN EXP PHARMACOL P, V35, P310, DOI 10.1111/j.1440-1681.2007.04824.x
   Zhang Y, 2015, MOL NUTR FOOD RES, V59, P1443, DOI 10.1002/mnfr.201500016
   Zhangdi HJ, 2019, WORLD J GASTROENTERO, V25, P4835, DOI 10.3748/wjg.v25.i33.4835
   Zhao XA, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/5738101
   Zhou D, 2019, WORLD J GASTROENTERO, V25, P2019, DOI 10.3748/wjg.v25.i17.2019
   Zhou R, 2018, CELL PHYSIOL BIOCHEM, V51, P2397, DOI 10.1159/000495898
NR 150
TC 7
Z9 9
U1 2
U2 15
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PD APR 22
PY 2020
VL 2020
AR 5462063
DI 10.1155/2020/5462063
PG 19
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA LM7AD
UT WOS:000532400200010
PM 32382557
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Iorga, RA
   Bacalbasa, N
   Bratu, OG
   Radu, FI
   Diaconu, CC
AF Iorga, Roua A.
   Bacalbasa, Nicolae
   Bratu, Ovidiu G.
   Radu, Florentina Ionita
   Diaconu, Camelia C.
TI The impact of infection with hepatitis C virus on cardiovascular risk
SO AMERICAN JOURNAL OF CARDIOVASCULAR DISEASE
LA English
DT Review
DE Hepatitis C virus; insulin resistance; cardiovascular risk; metabolic
   syndrome; diabetes mellitus
ID CHRONIC HCV INFECTION; METABOLIC SYNDROME; DIABETES-MELLITUS;
   ATHEROSCLEROSIS; DISEASE; RIBAVIRIN; DASABUVIR; FOCUS
AB Chronic hepatitis C virus (HCV) infection represents a systemic disease, with a natural progression to hepatic steatosis, fibrosis, and finally, cirrhosis, with an increased risk of hepatocellular carcinoma. Besides the hepatic alterations, the systemic manifestations of chronic HCV infection, such as endothelial dysfunction and atherosclerosis, oxidative stress, insulin resistance, immunological alterations, are nowadays recognized as cardiovascular risk factors. Hepatitis C is associated with insulin resistance and increased risk for type 2 diabetes mellitus, carotid atherosclerosis and stroke, coronary artery disease and chronic heart failure, with a significant impact on the mortality and morbidity. This article represents an overview of the most prevalent and important systemic alterations of chronic HCV infection, with emphasis on their cardiovascular and metabolic effects due to a treatable disease.
C1 [Iorga, Roua A.; Diaconu, Camelia C.] Clin Emergency Hosp Bucharest, Bucharest, Romania.
   [Bacalbasa, Nicolae; Bratu, Ovidiu G.; Diaconu, Camelia C.] Univ Med & Pharm Carol Davila, Bucharest, Romania.
   [Bacalbasa, Nicolae] I Cantacuzino Clin Hosp, Bucharest, Romania.
   [Bratu, Ovidiu G.] Emergency Univ Cent Mil Hosp, Bucharest, Romania.
   [Bratu, Ovidiu G.] Acad Romanian Scientists, Bucharest, Romania.
   [Radu, Florentina Ionita] Univ Emergency Cent Mil Hosp Dr Carol Davila, Bucharest, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Academy of Romanian
   Scientists (AOSR)
RP Diaconu, CC (corresponding author), Carol Davila Univ Med & Pharm, Internal Med Dept, Clin Emergency Hosp Bucharest, 8 Calea Floreasca, Bucharest 014461, Romania.
EM drcameliadiaconu@gmail.com
RI bacalbasa, nicolae/HJZ-4552-2023; Bratu, Ovidiu/L-3040-2019; Diaconu,
   Camelia/A-2144-2019; Ionita Radu, Florentina/ADP-0898-2022
OI Ionita Radu, Florentina/0000-0001-9829-5035
CR Adinolfi LE, 2013, ATHEROSCLEROSIS, V231, P22, DOI 10.1016/j.atherosclerosis.2013.08.003
   Adinolfi LE, 2018, WORLD J GASTROENTERO, V24, P4617, DOI 10.3748/wjg.v24.i41.4617
   Babiker A, 2017, J CLIN TRANSL HEPATO, V5, P343, DOI 10.14218/JCTH.2017.00021
   Blach S, 2017, LANCET GASTROENTEROL, V2, P161, DOI 10.1016/S2468-1253(16)30181-9
   Boddi M, 2010, J CLIN VIROL, V47, P72, DOI 10.1016/j.jcv.2009.10.005
   Butt AA, 2017, CLIN INFECT DIS, V65, P557, DOI 10.1093/cid/cix359
   Chang ML, 2016, WORLD J GASTROENTERO, V22, P1461, DOI 10.3748/wjg.v22.i4.1461
   Cheng YL, 2015, ANN HEPATOL, V14, P181, DOI 10.1016/S1665-2681(19)30780-X
   Crisu GC, 2019, ROM J MIL MED, V122, P22
   Di Minno MND, 2020, INTERN EMERG MED, V15, P263, DOI 10.1007/s11739-019-02163-8
   Domont F, 2016, LIVER INT, V36, P621, DOI 10.1111/liv.13064
   Drazilova S, 2018, CAN J GASTROENTEROL, V2018, DOI 10.1155/2018/6150861
   Gaman MA, 2019, J MIND MED SCI, V6, P157, DOI 10.22543/7674.61.P157161
   Garcia JC, 2016, ENDOTHELIAL DYSFUNCT
   HANSSON GK, 1989, ARTERIOSCLEROSIS, V9, P567, DOI 10.1161/01.ATV.9.5.567
   Huang YW, 2014, HEPATOLOGY, V60, P807, DOI 10.1002/hep.27212
   Jinga M, 2017, GASTROENTEROLOGY, V152, pS1148, DOI 10.1016/S0016-5085(17)33853-2
   Jones AT, 2018, COUNSELING HEPATITIS
   Kovacic JC, 2014, ENDOCRIN METAB CLIN, V43, P41, DOI 10.1016/j.ecl.2013.09.007
   Lonardo A, 2009, EXPERT REV ANTI-INFE, V7, P293, DOI [10.1586/eri.09.3, 10.1586/ERI.09.3]
   Mostafa A, 2010, GUT, V59, P1135, DOI 10.1136/gut.2009.202317
   Negro F, 2014, J HEPATOL, V61, pS69, DOI 10.1016/j.jhep.2014.08.003
   Núñez O, 2004, GUT, V53, P1665, DOI 10.1136/gut.2003.038364
   Olariu MC, 2019, Arch Balkan Med Union., V54, P699
   Petta S, 2018, J HEPATOL, V69, P18, DOI [10.1016/j.jhep.2018.02.015, 10.1016/j.jhep.2018.05.019]
   Targher G, 2007, J HEPATOL, V46, P1126, DOI 10.1016/j.jhep.2007.01.021
   Terrier B, 2013, AM J CARDIOL, V111, P265, DOI 10.1016/j.amjcard.2012.09.028
   Tsui JI, 2009, J CARD FAIL, V15, P451, DOI 10.1016/j.cardfail.2008.12.003
   Widmer R Jay, 2014, Glob Cardiol Sci Pract, V2014, P291, DOI 10.5339/gcsp.2014.43
   Zampino R, 2013, WORLD J HEPATOL, V5, P528, DOI 10.4254/wjh.v5.i10.528
NR 30
TC 10
Z9 10
U1 0
U2 1
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 2160-200X
J9 AM J CARDIOVASC DIS
JI Am. J. Cardiovasc. Dis.
PY 2020
VL 10
IS 3
BP 201
EP 206
PG 6
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA OA0RZ
UT WOS:000577505400009
PM 32923102
DA 2025-06-11
ER

PT J
AU Rodriguez-Peredo, SM
   Castellanos-Jankiewicz, AK
   Imaz-Rosshandler, I
   Espinoza-Camacho, MA
   Rangel-Escareño, C
   Muñoz-Sánchez, JL
   Melendez-Zajgla, J
   Tejero, ME
   Carbo, R
   Maldonado, V
   del Bosque-Plata, L
AF Rodriguez-Peredo, Sofia M.
   Castellanos-Jankiewicz, Ashley K.
   Imaz-Rosshandler, Ivan
   Espinoza-Camacho, Miguel A.
   Rangel-Escareno, Claudia
   Munoz-Sanchez, Jose L.
   Melendez-Zajgla, Jorge
   Elizabeth Tejero, M.
   Carbo, Roxana
   Maldonado, Vilma
   del Bosque-Plata, Laura
TI Modulation of the lung RNAome in a metabolic syndrome rat model
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
LA English
DT Article
DE Metabolic syndrome; lung; rats; RNAome; high sucrose diet
ID OBSTRUCTIVE PULMONARY-DISEASE; SYSTEMIC INFLAMMATION;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; FUNCTION IMPAIRMENT; MELATONIN;
   ASTHMA; RISK; CHOLESTEROL; HOMEOSTASIS
AB Metabolic syndrome (MetS) is characterized by a constellation of conditions that increase the risk for heart disease and other health problems. Although multiple organs are affected by this syndrome, research that focuses on the organs that are not directly involved in metabolism is lacking. Because MetS increases the risk for various lung diseases, we explored the effects of MetS on the lung in this study. We observed that the chronic consumption of a high sucrose diet for 24 weeks induced MetS in a rat model. Concomitant expression changes in 1,026 coding genes and two microRNAs were observed in the analyzed lung tissues. A network analysis showed degradation changes in the melatonin pathway, which plays a protective role in the lung; impairments of several inflammatory pathways (i.e., interferon-gamma and nuclear factor kappa B) were also revealed. Moreover, multiple olfactory genes were unexpectedly deregulated. Overall, the lungs of MetS mice exhibited an inflammatory phenotype with molecular changes that affected several signaling pathways that were related to melatonin metabolism, olfactory receptors and cytokine production. Additional research will be necessary to dissect a possible mechanism for the effects of this syndrome on the lung.
C1 [Rodriguez-Peredo, Sofia M.; Castellanos-Jankiewicz, Ashley K.; Imaz-Rosshandler, Ivan; Espinoza-Camacho, Miguel A.; Elizabeth Tejero, M.; del Bosque-Plata, Laura] Inst Nacl Med Genom, Lab Nutrigenet & Nutrigen, Perifer Sur 4809, Mexico City 14610, DF, Mexico.
   [Rodriguez-Peredo, Sofia M.; Munoz-Sanchez, Jose L.] Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Prolongac Carpio & Plan Ayala S-N, Mexico City 11340, DF, Mexico.
   [Carbo, Roxana] Inst Nacl Cardiol Ignacio Chavez, Dept Biomed Cardiovasc, Juan Badiano 1,Col Secc 16, Mexico City 14080, DF, Mexico.
   [Rangel-Escareno, Claudia] Inst Nacl Med Genom, Lab Genom Comp, Perifer Sur 4809, Mexico City 14610, DF, Mexico.
   [Melendez-Zajgla, Jorge] Inst Nacl Med Genom, Lab Genom Func, Perifer Sur 4809, Mexico City 14610, DF, Mexico.
   [Maldonado, Vilma] Inst Nacl Med Genom, Lab Epigenet, Perifer Sur 4809, Mexico City 14610, DF, Mexico.
   [Espinoza-Camacho, Miguel A.] Univ Nacl Autonoma Mexico, Posgrad Ciencias Biol, Ave Univ 3000, Mexico City 04510, DF, Mexico.
C3 Instituto Nacional de Medicina Genomica; Instituto Politecnico Nacional
   - Mexico; National Institute of Cardiology - Mexico; Instituto Nacional
   de Medicina Genomica; Instituto Nacional de Medicina Genomica; Instituto
   Nacional de Medicina Genomica; Universidad Nacional Autonoma de Mexico
RP del Bosque-Plata, L (corresponding author), Inst Nacl Med Genom, Lab Nutrigenet & Nutrigen, Perifer Sur 4809, Mexico City 14610, DF, Mexico.
EM ldelbosque@inmegen.gob.mx
RI Tejero, Maria/MBV-3355-2025; Carbó, Roxana/ABC-1951-2020;
   Melendez-Zajgla, Jorge/A-5708-2008; Rangel-Escareno, Claudia/F-4587-2012
OI Rangel-Escareno, Claudia/0000-0003-1303-0834; Carbo,
   Roxana/0000-0002-3581-398X
FU National Council for Science and Technology (CONACYT) [230762, 324898];
   CONACyT [169652]; National Institute of Cardiology "Ignacio Chavez"
   (SSA); Histology and Confocal Microscopy Facility of the INMEGEN; Gene
   Expression and Genotyping Facility of the INMEGEN
FX This work was supported by a PhD scholarship that was received by SMRP
   from the National Council for Science and Technology (CONACYT #230762,
   #324898) and by the following financial project: CONACyT, No. project
   169652, "Study of gene expression in the hypothalamus-adipose axis in a
   rat model with metabolic syndrome", Project manager: Laura del
   Bosque-Plata, Ph.D. We are thankful for the financial support of the
   National Institute of Cardiology "Ignacio Chavez" (SSA) for the animal
   model. We also thank the Histology and Confocal Microscopy Facility and
   the Gene Expression and Genotyping Facility of the INMEGEN for their
   support of this investigation.
CR Acuña-Castroviejo D, 2012, AGE, V34, P681, DOI 10.1007/s11357-011-9267-8
   Adams LA, 2007, ANN EPIDEMIOL, V17, P863, DOI 10.1016/j.annepidem.2007.05.013
   Adeyeye Olufunke O, 2012, Int Arch Med, V5, P20, DOI 10.1186/1755-7682-5-20
   Agarwal V, 2015, ELIFE, V4, DOI 10.7554/eLife.05005
   Ahima RS, 2006, DIABETES, V55, pS145, DOI 10.2337/db06-S018
   Akpinar EE, 2012, TUBERK TORAK, V60, P230, DOI 10.5578/tt.4018
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Bae MS, 2012, KOREAN J FAM MED, V33, P70, DOI 10.4082/kjfm.2012.33.2.70
   Barnes PJ, 2008, J CLIN INVEST, V118, P3546, DOI 10.1172/JCI36130
   Bolstad BM, 2003, BIOINFORMATICS, V19, P185, DOI 10.1093/bioinformatics/19.2.185
   Bonnefont-Rousselot D, 2011, J PINEAL RES, V50, P328, DOI 10.1111/j.1600-079X.2010.00847.x
   Brumpton BM, 2013, EUR RESPIR J, V42, P1495, DOI 10.1183/09031936.00046013
   Jankiewicz AKC, 2015, NUTR HOSP, V31, P2546
   Clini E, 2013, INTERN EMERG MED, V8, P283, DOI 10.1007/s11739-011-0700-x
   Cavalcante AGD, 2012, J PINEAL RES, V53, P238, DOI 10.1111/j.1600-079X.2012.00992.x
   Emanuela F, 2012, J NUTR METAB, V2012, DOI 10.1155/2012/476380
   Esposito K, 2012, DIABETES CARE, V35, P2402, DOI 10.2337/dc12-0336
   Fang CS, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-12
   Forno E, 2015, J ALLERGY CLIN IMMUN, V136, P304, DOI 10.1016/j.jaci.2015.01.010
   Galano A, 2011, J PINEAL RES, V51, P1, DOI 10.1111/j.1600-079X.2011.00916.x
   Gowdy KM, 2013, PULM PHARMACOL THER, V26, P430, DOI 10.1016/j.pupt.2012.06.002
   Kennedy AJ, 2010, DIS MODEL MECH, V3, P156, DOI 10.1242/dmm.003467
   Kim JY, 2012, MOL MED REP, V5, P1281, DOI 10.3892/mmr.2012.814
   Lago F, 2007, NAT CLIN PRACT RHEUM, V3, P716, DOI 10.1038/ncprheum0674
   Lazovic B., 2012, Timocki Medicinski Glasnik, V37, P229
   Lee EJ, 2009, J ASTHMA, V46, P339, DOI 10.1080/02770900802660931
   Lee MR, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms5410
   Luk AOY, 2008, DIABETES CARE, V31, P2357, DOI 10.2337/dc08-0971
   MacLean MR, 2010, ADV EXP MED BIOL, V661, P309, DOI 10.1007/978-1-60761-500-2_20
   Martins E, 2001, J PINEAL RES, V31, P363, DOI 10.1034/j.1600-079X.2001.310412.x
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Meigs JB, 2007, DIABETES CARE, V30, P1219, DOI 10.2337/dc06-2484
   Mirrakhimov AE, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-132
   Naveed B, 2012, AM J RESP CRIT CARE, V185, P392, DOI 10.1164/rccm.201109-1672OC
   Otabe S, 2012, J ENDOCRINOL, V213, P67, DOI 10.1530/JOE-11-0329
   Ouchi N, 2011, NAT REV IMMUNOL, V11, P85, DOI 10.1038/nri2921
   Phillips CM, 2013, NUTRIENTS, V5, P32, DOI 10.3390/nu5010032
   Rask-Madsen C, 2012, ARTERIOSCL THROM VAS, V32, P2052, DOI 10.1161/ATVBAHA.111.241919
   Shimizu Y, 2003, CLIN CANCER RES, V9, P774
   Tchernof A, 2013, PHYSIOL REV, V93, P359, DOI 10.1152/physrev.00033.2011
   Topal T, 2004, LIFE SCI, V75, P461, DOI 10.1016/j.lfs.2004.01.014
   van den Borst B, 2012, AM J CLIN NUTR, V96, P516, DOI 10.3945/ajcn.112.040774
   van Huisstede A, 2013, J OBES, V2013, DOI 10.1155/2013/131349
   Vernooy JHJ, 2013, PULM PHARMACOL THER, V26, P464, DOI 10.1016/j.pupt.2013.03.016
   Watz H, 2009, CHEST, V136, P1039, DOI 10.1378/chest.09-0393
   Wettenhall JM, 2004, BIOINFORMATICS, V20, P3705, DOI 10.1093/bioinformatics/bth449
   Xie ZT, 2015, TUMOR BIOL, V36, P6497, DOI 10.1007/s13277-015-3340-3
   Yang Y, 2012, INT J MOL MED, V29, P393, DOI 10.3892/ijmm.2011.855
   Yazdi HR, 2014, HUM EXP TOXICOL, V33, P574, DOI 10.1177/0960327113504973
NR 49
TC 0
Z9 0
U1 0
U2 2
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1936-2625
J9 INT J CLIN EXP PATHO
JI Int. J. Clin. Exp. Pathol.
PY 2017
VL 10
IS 5
BP 5379
EP +
PG 15
WC Oncology; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Pathology
GA EW1UG
UT WOS:000402279600044
DA 2025-06-11
ER

PT J
AU Taranu, I
   Racataianu, N
   Drugan, C
   Catana, CS
   Mirea, AM
   Miclea, D
   Bolboaca, SD
AF Taranu, Ioana
   Racataianu, Nicoleta
   Drugan, Cristina
   Catana, Cristina-Sorina
   Mirea, Andreea-Manuela
   Miclea, Diana
   Bolboaca, Sorana D.
TI Exploratory Longitudinal Analysis of the Circulating CHIT1 Activity in
   Pediatric Patients with Obesity
SO CHILDREN-BASEL
LA English
DT Article
DE human chitotriosidase (CHIT1); longitudinal analysis; children; obesity;
   insulin resistance (IR); inflammation; puberty; abdominal obesity; 24
   base-pair duplication
ID SUBCUTANEOUS ADIPOSE-TISSUE; BODY-MASS INDEX; CARDIOMETABOLIC
   RISK-FACTORS; HDL-CHOLESTEROL RATIO; ENDOPLASMIC-RETICULUM STRESS; 3RD
   NATIONAL-HEALTH; INSULIN-RESISTANCE; METABOLIC SYNDROME; CHITOTRIOSIDASE
   ACTIVITY; WAIST CIRCUMFERENCE
AB Macrophage activation and cytokine release play a pivotal role in inflammation-mediated metabolic disturbances in obesity. The proinflammatory macrophage secretes human chitotriosidase (CHIT1). The expression of the CHIT1 in visceral adipose tissue is associated with cytokine production. Our study aimed to assess whether the CHIT1 circulating activity, as a macrophage activation indicator, reflects the change of the adiposity level and the insulin resistance (IR) in children with obesity. We longitudinally (median follow-up period of 7 months; IQR [5 to 8.5] and {2 to 13} months) evaluated the CHIT1 circulating activity, the adiposity level (waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WtHR), and body mass index (BMI)-for-age z score), and two surrogate markers of IR (Homeostatic Model Assessment for Insulin Resistance, HOMA-IR and the triglycerides-to-high density lipoprotein cholesterol ratio, TG/HDLc) in 29 pediatric patients (16 girls and 13 boys) with obesity. We found a significant reduction in CHIT1 circulating activity (Wilcoxon test, p = 0.015) and a decrease in TG/HDLc at the follow-up evaluation (Wilcoxon test, p < 0.001). Indicators of adiposity were positively correlated with HOMA-IR at baseline, among which WC was the sole indicator associated with HOMA-IR (Spearman's rank correlation coefficients, p < 0.05) at follow-up. Human chitotriosidase has the potential to be a valuable measure of the progression of subclinical inflammation in children with obesity. Subclinical inflammation, as expressed by the circulating CHIT1 activity, progresses independently of the abdominal adiposity, as measured by the clinical indicators, and is associated with a change in insulin resistance.
C1 [Taranu, Ioana; Bolboaca, Sorana D.] Iuliu Hatieganu Univ Med & Pharm, Dept Med Informat & Biostat, Louis Pasteur Str,6, Cluj Napoca 400349, Romania.
   [Taranu, Ioana; Mirea, Andreea-Manuela] Emergency Pediat Hosp, Pediat Clin 1, Calea Motilor 68, Cluj Napoca 400370, Romania.
   [Racataianu, Nicoleta] Infect Dis Clin Hosp, Integrated Ambulatory Endocrinol, Calea Motilor 19, Cluj Napoca 400000, Romania.
   [Drugan, Cristina; Catana, Cristina-Sorina] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Dept Med Biochem, Louis Pasteur Str,6, Cluj Napoca 400349, Romania.
   [Miclea, Diana] Iuliu Hatieganu Univ Med & Pharm, Dept Med Genet, Louis Pasteur Str,6, Cluj Napoca 400349, Romania.
C3 Iuliu Hatieganu University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy; Iuliu Hatieganu University of
   Medicine & Pharmacy
RP Bolboaca, SD (corresponding author), Iuliu Hatieganu Univ Med & Pharm, Dept Med Informat & Biostat, Louis Pasteur Str,6, Cluj Napoca 400349, Romania.
EM sbolboaca@umfcluj.ro
RI catana, cristina/AGO-3947-2022; Gheorghiu, Ioana/JXN-8469-2024; Mirea,
   Andreea-Manuela/I-3147-2018; Drugan, Cristina/C-8534-2015; Bolboaca,
   Sorana D./E-4457-2010
OI Catana, Cristina/0000-0002-8899-6265; Drugan,
   Cristina/0000-0001-9136-2530; Gheorghiu, Ioana/0000-0002-7779-3147;
   Racataianu, Nicoleta/0000-0002-4397-3182; Bolboaca, Sorana
   D./0000-0002-2342-4311
CR Abraham TM, 2015, CIRCULATION, V132, P1639, DOI 10.1161/CIRCULATIONAHA.114.015000
   Ahrens W, 2014, INT J OBESITY, V38, pS4, DOI 10.1038/ijo.2014.130
   Armocida B, 2022, LANCET CHILD ADOLESC, V6, P367, DOI 10.1016/S2352-4642(22)00073-6
   Barlow SE, 1998, PEDIATRICS, V102, DOI 10.1542/peds.102.3.e29
   Bays HE, 2013, J CLIN LIPIDOL, V7, P304, DOI 10.1016/j.jacl.2013.04.001
   Bjorge T, 2008, AM J EPIDEMIOL, V168, P30, DOI 10.1093/aje/kwn096
   Boden G, 2008, DIABETES, V57, P2438, DOI 10.2337/db08-0604
   Boot RG, 1998, J BIOL CHEM, V273, P25680, DOI 10.1074/jbc.273.40.25680
   Cali AMG, 2009, HEPATOLOGY, V49, P1896, DOI 10.1002/hep.22858
   Cancello R, 2006, DIABETES, V55, P1554, DOI 10.2337/db06-0133
   Cao C, 2022, METABOLISM, V132, DOI 10.1016/j.metabol.2022.155216
   Caprio S, 2020, NAT METAB, V2, P223, DOI 10.1038/s42255-020-0183-z
   Caprio S, 2018, HORM MOL BIOL CLIN I, V33, DOI 10.1515/hmbci-2018-0005
   Chaychenko T, 2021, HORM RES PAEDIAT, V93, P622, DOI 10.1159/000515730
   Cinti S, 2005, J LIPID RES, V46, P2347, DOI 10.1194/jlr.M500294-JLR200
   Cook S, 2003, ARCH PEDIAT ADOL MED, V157, P821, DOI 10.1001/archpedi.157.8.821
   Correale J, 2011, MULT SCLER J, V17, P521, DOI 10.1177/1352458510392619
   Cotillard A, 2014, J CLIN ENDOCR METAB, V99, pE1466, DOI 10.1210/jc.2014-1074
   Dattani M.T, 2020, BROOKS CLIN PEDIAT E, V7th ed., P701
   de Ferranti SD, 2004, CIRCULATION, V110, P2494, DOI 10.1161/01.CIR.0000145117.40114.C7
   de Giorgis T, 2014, EUR J ENDOCRINOL, V170, P173, DOI 10.1530/EJE-13-0452
   de Onis M, 2007, B WORLD HEALTH ORGAN, V85, P660, DOI 10.2471/BLT.07.043497
   Di Bonito P, 2015, NUTR METAB CARDIOVAS, V25, P489, DOI 10.1016/j.numecd.2015.01.012
   Di Bonito P, 2012, DIABETES CARE, V35, P158, DOI 10.2337/dc11-1456
   Di Rosa M, 2013, CELL BIOCHEM BIOPHYS, V66, P239, DOI 10.1007/s12013-012-9471-x
   Di Rosa M, 2013, INFLAMMATION, V36, P482, DOI 10.1007/s10753-012-9569-8
   Di Rosa M, 2013, HEPATOL RES, V43, P267, DOI 10.1111/j.1872-034X.2012.01063.x
   Dong YY, 2021, DIABET METAB SYND OB, V14, P4579, DOI 10.2147/DMSO.S337412
   Faienza MF, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19148282
   Feingold K.R, 2020, Obesity and Dyslipidemia. Endotext
   Fox CS, 2007, CIRCULATION, V116, P39, DOI 10.1161/CIRCULATIONAHA.106.675355
   Fox KR, 2000, INT J OBESITY, V24, P1653, DOI 10.1038/sj.ijo.0801464
   Giannini C, 2011, DIABETES CARE, V34, P1869, DOI 10.2337/dc10-2234
   Hannon TS, 2006, PEDIATR RES, V60, P759, DOI 10.1203/01.pdr.0000246097.73031.27
   Hardy OT, 2011, SURG OBES RELAT DIS, V7, P60, DOI 10.1016/j.soard.2010.05.013
   Harman-Boehm I, 2007, J CLIN ENDOCR METAB, V92, P2240, DOI 10.1210/jc.2006-1811
   Hill DA, 2018, P NATL ACAD SCI USA, V115, pE5096, DOI 10.1073/pnas.1802611115
   Hoffer FA, 2005, SEMIN ULTRASOUND CT, V26, P212, DOI 10.1053/j.sult.2005.04.002
   HOLLAK CEM, 1994, J CLIN INVEST, V93, P1288, DOI 10.1172/JCI117084
   Horesh A, 2021, CURR OBES REP, V10, P301, DOI 10.1007/s13679-021-00439-9
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   Huber J, 2008, J CLIN ENDOCR METAB, V93, P3215, DOI 10.1210/jc.2007-2630
   Inouye KE, 2007, DIABETES, V56, P2242, DOI 10.2337/db07-0425
   Istiqomah E, 2019, PAEDIATR INDONES, V59, P265, DOI 10.14238/pi59.5.2019.265-70
   Iwani NAKZ, 2017, SCI REP-UK, V7, DOI 10.1038/srep40055
   Jaitin DA, 2019, CELL, V178, P686, DOI 10.1016/j.cell.2019.05.054
   Kabaroglu C, 2012, CLIN BIOCHEM, V45, P281, DOI 10.1016/j.clinbiochem.2011.12.007
   Kim JA, 2008, DIABETES METAB, V34, P126, DOI 10.1016/j.diabet.2007.10.012
   Kursawe R, 2016, DIABETES, V65, P610, DOI 10.2337/db15-1478
   Kursawe R, 2013, DIABETES, V62, P837, DOI 10.2337/db12-0889
   Lebovitz HE, 2001, EXP CLIN ENDOCR DIAB, V109, pS135, DOI 10.1055/s-2001-18576
   Lee P, 2007, BLOOD CELL MOL DIS, V39, P353, DOI 10.1016/j.bcmd.2007.06.013
   Lee S, 2006, J PEDIATR-US, V148, P188, DOI 10.1016/j.jpeds.2005.10.001
   Lee YS, 2011, DIABETES, V60, P2474, DOI 10.2337/db11-0194
   Létuvé S, 2010, AM J PATHOL, V176, P638, DOI 10.2353/ajpath.2010.090455
   Li ML, 2022, PEDIATR RES, V92, P322, DOI 10.1038/s41390-021-01754-6
   Lumeng CN, 2007, J CLIN INVEST, V117, P175, DOI 10.1172/JCI29881
   Lumeng CN, 2008, DIABETES, V57, P3239, DOI 10.2337/db08-0872
   MARSHALL WA, 1969, ARCH DIS CHILD, V44, P291, DOI 10.1136/adc.44.235.291
   MARSHALL WA, 1970, ARCH DIS CHILD, V45, P13, DOI 10.1136/adc.45.239.13
   Marwitz SE, 2020, ENDOCRINOL METAB, V35, P847, DOI 10.3803/EnM.2020.771
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Michailidou Z, 2019, CURR OPIN PHYSIOL, V12, P39, DOI 10.1016/j.cophys.2019.09.005
   Olefsky JM, 2010, ANNU REV PHYSIOL, V72, P219, DOI 10.1146/annurev-physiol-021909-135846
   Owen CG, 2009, INT J OBESITY, V33, P866, DOI 10.1038/ijo.2009.102
   Perreault M, 2001, NAT MED, V7, P1138, DOI 10.1038/nm1001-1138
   Polat TB, 2008, J PEDIATR ENDOCR MET, V21, P1031
   Püschel GP, 2022, J CLIN MED, V11, DOI 10.3390/jcm11154358
   Quijada Z, 2008, PEDIATR DIABETES, V9, P464, DOI 10.1111/j.1399-5448.2008.00406.x
   Roden M, 1996, J CLIN INVEST, V97, P2859, DOI 10.1172/JCI118742
   Samad F, 1997, MOL MED, V3, P37, DOI 10.1007/BF03401666
   Sartipy P, 2003, P NATL ACAD SCI USA, V100, P7265, DOI 10.1073/pnas.1133870100
   Seo JY, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0186050
   Shimobayashi M, 2018, J CLIN INVEST, V128, P1538, DOI 10.1172/JCI96139
   Shulman GI, 2014, NEW ENGL J MED, V371, P1131, DOI 10.1056/NEJMra1011035
   Sinaiko AR, 2006, HYPERTENSION, V48, P730, DOI 10.1161/01.HYP.0000237863.24000.50
   Singer K, 2017, J CLIN INVEST, V127, P65, DOI [10.1172/JCI88882, 10.1172/jci88882]
   Sommer A, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1062-9
   Suliga E, 2009, NUTR RES REV, V22, P137, DOI 10.1017/S0954422409990096
   Tagi VM, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00342
   Taksali SE, 2008, DIABETES, V57, P367, DOI 10.2337/db07-0932
   Taranu I, 2022, J CLIN MED, V11, DOI 10.3390/jcm11133634
   Umer A, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4691-z
   van Eijk M, 2005, INT IMMUNOL, V17, P1505, DOI 10.1093/intimm/dxh328
   van Eijk M, 2010, FEBS LETT, V584, P3165, DOI 10.1016/j.febslet.2010.06.001
   Viner RM, 2005, ARCH DIS CHILD, V90, P10, DOI 10.1136/adc.2003.036467
   Visser M, 1999, JAMA-J AM MED ASSOC, V282, P2131, DOI 10.1001/jama.282.22.2131
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Weiss R, 2003, LANCET, V362, P951, DOI 10.1016/S0140-6736(03)14364-4
   Weyer C, 2002, ATHEROSCLEROSIS, V161, P233, DOI 10.1016/S0021-9150(01)00626-8
   Wiebe N, 2021, JAMA NETW OPEN, V4, DOI 10.1001/jamanetworkopen.2021.1263
   Wu HZ, 2020, CIRC RES, V126, P1549, DOI 10.1161/CIRCRESAHA.119.315896
   Wu HZ, 2017, J CLIN INVEST, V127, P43, DOI [10.1172/JCI88880, 10.1172/jci88880]
   Yamanaka AB, 2021, PREV CHRONIC DIS, V18, DOI 10.5888/pcd18.210021
   Yap J, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.00714
   Yu YH, 2005, CIRC RES, V96, P1042, DOI 10.1161/01.RES.0000165803.47776.38
   Zimmet P, 2007, PEDIATR DIABETES, V8, P299, DOI 10.1111/j.1399-5448.2007.00271.x
NR 97
TC 0
Z9 0
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9067
J9 CHILDREN-BASEL
JI Children-Basel
PD JAN
PY 2023
VL 10
IS 1
AR 124
DI 10.3390/children10010124
PG 13
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 7X9RT
UT WOS:000914530800001
PM 36670674
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mazidi, M
   Katsiki, N
   Mikhailidis, DP
   Banach, M
AF Mazidi, Mohsen
   Katsiki, Niki
   Mikhailidis, Dimitri P.
   Banach, Maciej
TI Link between plasma trans-fatty acid and fatty liver is moderated
   by adiposity
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Trans-fatty acids; Non-alcoholic fatty liver disease; Liver tests; Fatty
   liver index; Body mass
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC SYNDROME; DISEASE;
   INFLAMMATION; DIETS; STEATOHEPATITIS; SEVERITY; INJURY; BLOOD
AB Background: The prevalence of non-alcoholic fatty liver disease (NAFLD) is rising. This increase may be associated with obesity. It has been suggested that trans-fatty acids (TFAs) play an important role in non-communicable diseases.
   Aim: We examined the link between liver tests, fatty liver index (FLI) and plasma TFAs. Furthermore, we evaluated the impact of adiposity on this link.
   Methods: The National Health and Nutrition Examination Survey (NHANES) was used to obtain the data on TFAs and liver function biomarkers. We took account of complex NHANES data, masked variance and weighting methodology.
   Results: Of the 4252 participants, 46.4% were men. The mean age was 50.6 years overall; 51.3 years for men and 49.8 years for women (p - 0.206). In a fully adjusted model (demographic and clinical factors), FU increased as trans-9-hexadecenoic acid and trans-11-octadecenoic acid levels increased; FLI was 38.1 and 42.3 for the first quarter (Q1) of trans-9-hexadecenoic acid and trans-11-octadecenoic add, respectively, reaching 65.1 and 69.3 for the highest quarters (Q4) (p < 0.001 for all comparisons). Multivariable logistic regression showed for all four studied TFAs, the likelihood of NAFLD (determined by FU) increased with increasing TFAs levels (quartiles) in a stepwise manner (p < 0.001 for all comparisons). Based on moderation analysis, a strong impact of body mass index (BMI) on the link between FLI and TFAs was observed.
   Conclusions: Our results suggest a direct significant association between plasma TFAs, liver tests and NAFLD (assessed by FU). Furthermore, BMI was shown to mediate this relationship. These findings highlight the importance of avoiding TFAs consumption in order to minimize cardiometabolic risk. (C) 2018 Published by Elsevier B.V.
C1 [Mazidi, Mohsen] Chalmers Univ Technol, Dept Biol & Biol Engn, Food & Nutr Sci, SE-41296 Gothenburg, Sweden.
   [Katsiki, Niki] Aristotle Univ Thessaloniki, Med Sch, Propedeut Dept Internal Med 2, Hippokrat Hosp, Thessaloniki, Greece.
   [Mikhailidis, Dimitri P.] UCL, Med Sch, Dept Clin Biochem, Royal Free Campus, London, England.
   [Banach, Maciej] Med Univ Lodz, Chair Nephrol & Hypertens, Dept Hypertens, Lodz, Poland.
   [Banach, Maciej] PMMHRI, Lodz, Poland.
   [Banach, Maciej] Univ Zielona Gora, Cardiovasc Res Ctr, Zielona Gora, Poland.
C3 Chalmers University of Technology; Aristotle University of Thessaloniki;
   University of London; University College London; Medical University
   Lodz; University of Zielona Gora
RP Mazidi, M (corresponding author), Chalmers Univ Technol, Dept Biol & Biol Engn, Food & Nutr Sci, SE-41296 Gothenburg, Sweden.
EM mazidi@chalmers.se
RI Linn, Shai/N-3079-2019; Mikhailidis, Dimitri/A-1869-2013; KATSIKI,
   NIKI/ADE-7999-2022; Banach, Maciej/A-1271-2009
OI KATSIKI, NIKI/0000-0003-0894-2644; Banach, Maciej/0000-0001-6690-6874
FU TWAS studentship of the Chinese Academy of Sciences
FX MM was supported by a TWAS studentship of the Chinese Academy of
   Sciences.
CR Adriano LS, 2016, BRIT J NUTR, V115, P2189, DOI 10.1017/S0007114516001410
   Athyros VG, 2017, METABOLISM, V71, P17, DOI 10.1016/j.metabol.2017.02.014
   Athyros VG, 2013, ANGIOLOGY, V64, P572, DOI 10.1177/0003319713481101
   Athyros VG, 2010, LANCET, V376, P1916, DOI 10.1016/S0140-6736(10)61272-X
   Baer DJ, 2004, AM J CLIN NUTR, V79, P969
   Bakunina N, 2015, IMMUNOLOGY, V144, P365, DOI 10.1111/imm.12443
   Bendsen NT, 2011, NUTR DIABETES, V1, DOI 10.1038/nutd.2010.4
   Colandré ME, 2003, BRIT J NUTR, V89, P631, DOI 10.1079/BJN2003834
   Coulon S, 2012, CYTOKINE, V59, P442, DOI 10.1016/j.cyto.2012.05.001
   Dhibi M, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-65
   Estadella D, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/137579
   Horton JD, 1998, P NATL ACAD SCI USA, V95, P5987, DOI 10.1073/pnas.95.11.5987
   Huang J, 2016, SCI REP-UK, V6, DOI 10.1038/srep29938
   Jacome-Sosa MM, 2014, J NUTR BIOCHEM, V25, P692, DOI 10.1016/j.jnutbio.2014.02.011
   Kang HL, 2006, AM J GASTROENTEROL, V101, P2247, DOI 10.1111/j.1572-0241.2006.00719.x
   Katsiki N, 2018, CURR VASC PHARMACOL, V16, P219, DOI 10.2174/1570161115666170621075619
   Kavanagh K, 2007, OBESITY, V15, P1675, DOI 10.1038/oby.2007.200
   Kawano Y, 2013, J GASTROENTEROL, V48, P434, DOI 10.1007/s00535-013-0758-5
   Klein-Platat C, 2005, AM J CLIN NUTR, V82, P1178, DOI 10.1093/ajcn/82.6.1178
   Koppe S. W., 2009, AM J PHYSIOL-GASTR L, V297, pG78
   Koyama T, 2016, J CARDIOL, V67, P347, DOI 10.1016/j.jjcc.2015.06.002
   Kris-Etherton PM, 2012, LIPIDS, V47, P931, DOI 10.1007/s11745-012-3704-z
   Leclercq IA, 2007, J HEPATOL, V47, P142, DOI 10.1016/j.jhep.2007.04.002
   Machado RM, 2010, J NUTR, V140, P1127, DOI 10.3945/jn.109.117937
   Maritim AC, 2003, J BIOCHEM MOL TOXIC, V17, P24, DOI 10.1002/jbt.10058
   Masarone M, 2014, REV RECENT CLIN TRIA, V9, P126, DOI 10.2174/1574887109666141216111143
   Mataix J, 1998, FREE RADICAL BIO MED, V24, P511, DOI 10.1016/S0891-5849(97)00288-8
   Matthews VB, 2010, DIABETOLOGIA, V53, P2431, DOI 10.1007/s00125-010-1865-y
   Mazidi M, 2018, ANN MED, V50, P1, DOI 10.1080/07853890.2017.1325967
   Mazidi M, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0571-x
   Mazidi M, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0527-1
   Mitmesser SH, 2005, J NUTR BIOCHEM, V16, P178, DOI 10.1016/j.jnutbio.2004.11.004
   Motard-Bélanger A, 2008, AM J CLIN NUTR, V87, P593, DOI 10.1093/ajcn/87.3.593
   Mozaffarian D, 2006, NEW ENGL J MED, V354, P1601, DOI 10.1056/NEJMra054035
   Mozaffarian D, 2004, AM J CLIN NUTR, V79, P606, DOI 10.1093/ajcn/79.4.606
   Nagaya T, 2015, BBA CLIN, V3, P168, DOI 10.1016/j.bbacli.2015.02.001
   Okada Y, 2013, J GASTROEN HEPATOL, V28, P29, DOI 10.1111/jgh.12270
   OZAKI M, 1995, ARCH BIOCHEM BIOPHYS, V318, P439, DOI 10.1006/abbi.1995.1252
   Perumpail B. J., 2017, DIS BASEL SWITZERLAN, V5
   Preacher KJ, 2008, BEHAV RES METHODS, V40, P879, DOI 10.3758/BRM.40.3.879
   Reccia I, 2017, METABOLISM, V72, P94, DOI 10.1016/j.metabol.2017.04.011
   Rector RS, 2010, J HEPATOL, V52, P727, DOI 10.1016/j.jhep.2009.11.030
   Risé P, 2007, PROSTAG LEUKOTR ESS, V76, P363, DOI 10.1016/j.plefa.2007.05.003
   Ruhl CE, 2015, ALIMENT PHARM THER, V41, P65, DOI 10.1111/apt.13012
   SLINKER BK, 1985, AM J PHYSIOL, V249, pR1, DOI 10.1152/ajpregu.1985.249.1.R1
   SOMMERFELD M, 1983, PROG LIPID RES, V22, P221, DOI 10.1016/0163-7827(83)90010-3
   Tak PP, 2001, J CLIN INVEST, V107, P7, DOI 10.1172/JCI11830
   Videla LA, 2004, FREE RADICAL BIO MED, V37, P1499, DOI 10.1016/j.freeradbiomed.2004.06.033
   Younossi Z, 2018, NAT REV GASTRO HEPAT, V15, P11, DOI 10.1038/nrgastro.2017.109
   Zhang W, 2013, DIGEST DIS SCI, V58, P3198, DOI 10.1007/s10620-013-2775-x
NR 50
TC 17
Z9 19
U1 0
U2 20
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD DEC 1
PY 2018
VL 272
BP 316
EP 322
DI 10.1016/j.ijcard.2018.07.061
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GV3VI
UT WOS:000446025200066
PM 30072152
DA 2025-06-11
ER

PT S
AU Puttabyatappa, M
   Padmanabhan, V
AF Puttabyatappa, Muraly
   Padmanabhan, Vasantha
BE MauvaisJarvis, F
TI Prenatal Testosterone Programming of Insulin Resistance in the Female
   Sheep
SO SEX AND GENDER FACTORS AFFECTING METABOLIC HOMEOSTASIS, DIABETES AND
   OBESITY
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
ID POLYCYSTIC-OVARY-SYNDROME; CATCH-UP GROWTH; METABOLIC SYNDROME;
   UNITED-STATES; DEVELOPMENTAL ORIGINS; OXIDATIVE STRESS; EXCESS;
   SENSITIVITY; ADIPONECTIN; OBESITY
AB Insulin resistance, a common feature of metabolic disorders such as obesity, nonalcoholic fatty liver disease, metabolic syndrome, and polycystic ovary syndrome, is a risk factor for development of diabetes. Because sex hormones orchestrate the establishment of sex-specific behavioral, reproductive, and metabolic differences, a role for them in the developmental origin of insulin resistance is also to be expected. Female sheep exposed to male levels of testosterone during fetal life serve as an excellent translational model for delineating programming of insulin resistance. This chapter summarizes the ontogeny of insulin resistance, the tissue-specific changes in insulin sensitivity, and the various factors that are involved in the programming and maintenance of the insulin resistance in adult female sheep that were developmentally exposed to fetal male levels of testosterone during the sexual-differentiation window.
C1 [Puttabyatappa, Muraly; Padmanabhan, Vasantha] Univ Michigan, Dept Pediat, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan
RP Padmanabhan, V (corresponding author), Univ Michigan, Dept Pediat, Ann Arbor, MI 48109 USA.
EM vasantha@umich.edu
RI Puttabyatappa, Muraly/K-2598-2015
FU NIH [P01 HD44232]
FX This work was supported by NIH P01 HD44232.
CR Abbott DH, 2013, MOL CELL ENDOCRINOL, V373, P21, DOI 10.1016/j.mce.2013.01.013
   Abel ED, 2004, FRONT BIOSCI-LANDMRK, V9, P201, DOI 10.2741/1216
   Achari AE, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18061321
   Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Azziz R, 2006, J CLIN ENDOCR METAB, V91, P4237, DOI 10.1210/jc.2006-0178
   Barker DJP, 2004, J AM COLL NUTR, V23, p588S, DOI 10.1080/07315724.2004.10719428
   Barry JS, 2008, THERIOGENOLOGY, V69, P55, DOI 10.1016/j.theriogenology.2007.09.021
   Bashan N, 2009, PHYSIOL REV, V89, P27, DOI 10.1152/physrev.00014.2008
   BECKPECCOZ P, 1991, J CLIN ENDOCR METAB, V73, P525, DOI 10.1210/jcem-73-3-525
   Boonyaratanakornkit V, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/140196
   Bramble MS, 2016, SCI REP-UK, V6, DOI 10.1038/srep36916
   Brons C, 2017, EUR J ENDOCRINOL, V176, pR67, DOI 10.1530/EJE-16-0488
   Cardoso RC, 2016, ENDOCRINOLOGY, V157, P522, DOI 10.1210/en.2015-1565
   Cardoso RC, 2015, NEUROENDOCRINOLOGY, V102, P226, DOI 10.1159/000381830
   Caselli C, 2014, MOL GENET METAB, V113, P155, DOI 10.1016/j.ymgme.2014.09.003
   Clarke I J, 1992, Ciba Found Symp, V168, P87
   Crespi EJ, 2006, J PHYSIOL-LONDON, V572, P119, DOI 10.1113/jphysiol.2005.103929
   DEEMING DC, 1989, AM ZOOL, V29, P973
   Dimitriadis G, 2011, DIABETES RES CLIN PR, V93, pS52, DOI 10.1016/S0168-8227(11)70014-6
   Ertunc ME, 2016, J LIPID RES, V57, P2099, DOI 10.1194/jlr.R066514
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   Fauser BCJM, 2004, HUM REPROD, V19, P41, DOI 10.1093/humrep/deh098
   Flegal KM, 2016, JAMA-J AM MED ASSOC, V315, P2284, DOI 10.1001/jama.2016.6458
   Fu YC, 2014, PROG MOL BIOL TRANSL, V121, P293, DOI 10.1016/B978-0-12-800101-1.00009-0
   Hanson M, 2011, AM J CLIN NUTR, V94, p1754S, DOI 10.3945/ajcn.110.001206
   Hogg K, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024877
   Jones H, 2012, J CLIN ENDOCR METAB, V97, P3709, DOI 10.1210/jc.2012-1382
   JOST A, 1983, PSYCHONEUROENDOCRINO, V8, P183, DOI 10.1016/0306-4530(83)90055-0
   Kadowaki T, 2005, ENDOCR REV, V26, P439, DOI 10.1210/er.2005-0005
   Kahn BB, 2000, J CLIN INVEST, V106, P473, DOI 10.1172/JCI10842
   King AJ, 2007, AM J PHYSIOL-ENDOC M, V292, pE1837, DOI 10.1152/ajpendo.00668.2006
   larke I. J., 1992, CIBA F SYMP, V168, P95
   Liu WS, 2016, CELL MOL LIFE SCI, V73, P1969, DOI 10.1007/s00018-016-2161-x
   Liu Y, 2014, BEST PRACT RES CL EN, V28, P33, DOI 10.1016/j.beem.2013.08.003
   Livingstone C, 2002, CLIN SCI, V102, P151, DOI 10.1042/cs1020151
   Lu CX, 2016, BIOL REPROD, V94, DOI 10.1095/biolreprod.115.136283
   LUCAS A, 1991, CIBA F SYMP, V156, P38
   Macut D, 2013, FRONT HORM RES, V40, P51, DOI 10.1159/000341683
   Manikkam M, 2004, ENDOCRINOLOGY, V145, P790, DOI 10.1210/en.2003-0478
   Mauvais-Jarvis F, 2015, BIOL SEX DIFFER, V6, DOI 10.1186/s13293-015-0033-y
   MEISEL RL, 1981, SCIENCE, V213, P239, DOI 10.1126/science.7244634
   Melo AS, 2010, HUM REPROD, V25, P2124, DOI 10.1093/humrep/deq162
   Menke A, 2015, JAMA-J AM MED ASSOC, V314, P1021, DOI 10.1001/jama.2015.10029
   Moran LJ, 2015, TRENDS ENDOCRIN MET, V26, P136, DOI 10.1016/j.tem.2014.12.003
   MORISHIMA A, 1995, J CLIN ENDOCR METAB, V80, P3689, DOI 10.1210/jc.80.12.3689
   Morrison JL, 2010, PEDIATR NEPHROL, V25, P669, DOI 10.1007/s00467-009-1407-3
   Nada SE, 2010, ENDOCRINOLOGY, V151, P5165, DOI 10.1210/en.2010-0666
   Nijland MJ, 2008, CURR OPIN OBSTET GYN, V20, P132, DOI 10.1097/GCO.0b013e3282f76753
   Nikoulina SE, 2000, DIABETES, V49, P263, DOI 10.2337/diabetes.49.2.263
   NUUTILA P, 1995, DIABETES, V44, P31, DOI 10.2337/diabetes.44.1.31
   Ohlsson C, 2000, BIOCHEM BIOPH RES CO, V278, P640, DOI 10.1006/bbrc.2000.3827
   Padmanabhan V, 2014, J ANIM SCI, V92, P3199, DOI 10.2527/jas.2014-7637
   Padmanabhan V, 2010, ENDOCRINOLOGY, V151, P595, DOI 10.1210/en.2009-1015
   Padmanabhan V, 2016, ENDOCRINOLOGY, V157, P1328, DOI 10.1210/en.2016-1003
   Padmanabhan V, 2013, MOL CELL ENDOCRINOL, V373, P8, DOI 10.1016/j.mce.2012.10.005
   Pradhan AD, 2014, CLIN CHEM, V60, P44, DOI 10.1373/clinchem.2013.202549
   Puttabyatappa M, 2017, ENDOCRINOLOGY, V158, P2783, DOI 10.1210/en.2017-00460
   Rae M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0056263
   Ramaswamy S, 2016, SCI REP-UK, V6, DOI 10.1038/srep27408
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   Rao PM, 2013, NAT REV ENDOCRINOL, V9, P479, DOI 10.1038/nrendo.2013.122
   Rask-Madsen C, 2012, ARTERIOSCL THROM VAS, V32, P2052, DOI 10.1161/ATVBAHA.111.241919
   Recabarren SE, 2005, AM J PHYSIOL-ENDOC M, V289, pE801, DOI 10.1152/ajpendo.00107.2005
   Rochlani Y, 2015, CARDIOVASC DRUG THER, V29, P329, DOI 10.1007/s10557-015-6593-6
   Romeo GR, 2012, ARTERIOSCL THROM VAS, V32, P1771, DOI 10.1161/ATVBAHA.111.241869
   Ropero AB, 2008, STEROIDS, V73, P874, DOI 10.1016/j.steroids.2007.12.018
   Ruan H, 2016, J MOL CELL BIOL, V8, P101, DOI 10.1093/jmcb/mjw014
   Saltiel AR, 2001, NATURE, V414, P799, DOI 10.1038/414799a
   Savkur RS, 2001, NAT GENET, V29, P40, DOI 10.1038/ng704
   Sayiner M, 2016, CLIN LIVER DIS, V20, P205, DOI 10.1016/j.cld.2015.10.001
   Sir-Petermann T, 2005, HUM REPROD, V20, P2122, DOI 10.1093/humrep/dei009
   Sir-Petermann T, 2012, REV MED CHILE, V140, P919, DOI 10.4067/S0034-98872012000700015
   Soumaya K, 2013, ADV EXP MED BIOL, V771, P240
   Steckler T, 2005, ENDOCRINOLOGY, V146, P3185, DOI 10.1210/en.2004-1444
   Tang WY, 2007, REV ENDOCR METAB DIS, V8, P173, DOI 10.1007/s11154-007-9042-4
   Veiga-Lopez A, 2013, ENDOCRINOLOGY, V154, P1731, DOI 10.1210/en.2012-2145
   Veiga-Lopez A, 2011, BIOL REPROD, V84, P87, DOI 10.1095/biolreprod.110.086686
   Verdile G, 2015, MEDIAT INFLAMM, V2015, DOI 10.1155/2015/105828
   Villa J, 2011, CURR DIABETES REP, V11, P179, DOI 10.1007/s11892-011-0189-8
   vom Saal FS, 2016, J ANIM SCI, V94, P2722, DOI 10.2527/jas.2015-0211
   Vyas AK, 2016, SCI REP-UK, V6, DOI 10.1038/srep28335
   Wallace IR, 2013, CLIN ENDOCRINOL, V78, P321, DOI 10.1111/cen.12086
   Zawadski J., 1992, Polycystic ovary syndrome: diagnostic criteria for polycystic ovarian syndrome: towards a rational approach
NR 83
TC 19
Z9 19
U1 0
U2 1
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 0065-2598
EI 2214-8019
BN 978-3-319-70178-3; 978-3-319-70177-6
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2017
VL 1043
BP 575
EP 596
DI 10.1007/978-3-319-70178-3_25
D2 10.1007/978-3-319-70178-3
PG 22
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
   Endocrinology & Metabolism; Medicine, Research & Experimental
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Research &
   Experimental Medicine
GA BS3UO
UT WOS:000715520200028
PM 29224111
DA 2025-06-11
ER

PT J
AU Lisboa, QC
   Costa, SMF
   Couto, CA
AF Lisboa, Quelson Coelho
   Ferolla Costa, Silvia Marinho
   Couto, Claudia Alves
TI Current management of non-alcoholic fatty liver disease
SO REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
LA English
DT Review
DE non-alcoholic fatty liver disease; steatosis; steatohepatitis; metabolic
   syndrome; obesity
ID PLACEBO-CONTROLLED TRIAL; BARIATRIC SURGERY; VITAMIN-E; CARDIOVASCULAR
   EVENTS; URSODEOXYCHOLIC ACID; PHYSICAL-ACTIVITY; DOUBLE-BLIND;
   WEIGHT-LOSS; STEATOHEPATITIS; PIOGLITAZONE
AB Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic accumulation of lipid in patients who do not consume alcohol in amounts generally considered harmful to the liver. NAFLD is becoming a major liver disease in Eastern countries and it is related to insulin resistance and metabolic syndrome. Treatment has focused on improving insulin sensitivity, protecting the liver from oxidative stress, decreasing obesity and improving diabetes mellitus, dyslipidemia, hepatic inflammation and fibrosis. Lifestyle modification involving diet and enhanced physical activity associated with the treatment of underlying metabolic are the main stain in the current management of NAFLD. Insulin-sensitizing agents and antioxidants, especially thiazolidinediones and vitamin E, seem to be the most promising pharmacologic treatment for non-alcoholic steatohepatitis, but further long-term multicenter studies to assess safety are recommended.
C1 [Lisboa, Quelson Coelho] Univ Fed Minas Gerais, Hosp Clin, Inst Alfa Gastroenterol, Sci Appl Adult Hlth Emphasis Gastroenterol, Belo Horizonte, MG, Brazil.
   [Ferolla Costa, Silvia Marinho] Univ Fed Minas Gerais, Hosp Clin, Inst Alfa Gastroenterol, Sci Appl Adult Hlth, Belo Horizonte, MG, Brazil.
   [Couto, Claudia Alves] Univ Fed Minas Gerais, Hosp Clin, Inst Alfa Gastroenterol, Fac Med, Belo Horizonte, MG, Brazil.
C3 Universidade Federal de Minas Gerais; Universidade Federal de Minas
   Gerais; Universidade Federal de Minas Gerais
RP Lisboa, QC (corresponding author), Ave Prof Alfredo Balena 110, BR-30130100 Belo Horizonte, MG, Brazil.
EM quelsoncoelho@gmail.com
RI Couto, Claudia/H-7420-2013
OI Couto, Claudia/0000-0002-9776-4757
CR Adorini L, 2012, DRUG DISCOV TODAY, V17, P988, DOI 10.1016/j.drudis.2012.05.012
   Aithal GP, 2008, GASTROENTEROLOGY, V135, P1176, DOI 10.1053/j.gastro.2008.06.047
   Albu JB, 2010, DIABETES, V59, P627, DOI 10.2337/db09-1239
   Athyros VG, 2010, LANCET, V376, P1916, DOI 10.1016/S0140-6736(10)61272-X
   Baba CS, 2006, J GASTROEN HEPATOL, V21, P191, DOI 10.1111/j.1440-1746.2005.04233.x
   Ballestri S, 2016, J GASTROEN HEPATOL, V31, P936, DOI 10.1111/jgh.13264
   Belfort R, 2006, NEW ENGL J MED, V355, P2297, DOI 10.1056/NEJMoa060326
   Bellentani S, 2008, HEPATOLOGY, V47, P746, DOI 10.1002/hep.22009
   Birkenfeld AL, 2014, HEPATOLOGY, V59, P713, DOI 10.1002/hep.26672
   Boettcher E, 2012, ALIMENT PHARM THER, V35, P66, DOI 10.1111/j.1365-2036.2011.04912.x
   Bower G, 2015, OBES SURG, V25, P2280, DOI 10.1007/s11695-015-1691-x
   Brown JD, 2007, CIRCULATION, V115, P518, DOI 10.1161/CIRCULATIONAHA.104.475673
   Chavaez-Tapia NC, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007340.pub2
   Eslami L, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008623.pub2
   Fulcher J, 2015, LANCET, V385, P1397, DOI 10.1016/S0140-6736(14)61368-4
   Hafeez S, 2013, J OBES, V2013, DOI 10.1155/2013/839275
   Krakoff J, 2010, OBESITY, V18, P1762, DOI 10.1038/oby.2010.21
   Krasnoff JB, 2008, HEPATOLOGY, V47, P1158, DOI 10.1002/hep.22137
   Lassailly G, 2015, GASTROENTEROLOGY, V149, P379, DOI 10.1053/j.gastro.2015.04.014
   Lavine JE, 2011, JAMA-J AM MED ASSOC, V305, P1659, DOI 10.1001/jama.2011.520
   Lazo M, 2010, DIABETES CARE, V33, P2156, DOI 10.2337/dc10-0856
   Leuschner UFH, 2010, HEPATOLOGY, V52, P472, DOI 10.1002/hep.23727
   Li Y, 2013, BIOMED REP, V1, P57, DOI 10.3892/br.2012.18
   Lindor KD, 2004, HEPATOLOGY, V39, P770, DOI 10.1002/hep.20092
   Miller ER, 2005, ANN INTERN MED, V142, P37, DOI 10.7326/0003-4819-142-1-200501040-00110
   Mummadi RR, 2008, CLIN GASTROENTEROL H, V6, P1396, DOI 10.1016/j.cgh.2008.08.012
   Murphy CE, 2007, ANN PHARMACOTHER, V41, P2014, DOI 10.1345/aph.1K286
   Musso G, 2012, DIABETOLOGIA, V55, P885, DOI 10.1007/s00125-011-2446-4
   Musso G, 2010, HEPATOLOGY, V52, P79, DOI 10.1002/hep.23623
   Neuschwander-Tetri BA, 2015, LANCET, V385, P956, DOI 10.1016/S0140-6736(14)61933-4
   Nissen SE, 2007, NEW ENGL J MED, V356, P2457, DOI 10.1056/NEJMoa072761
   Oh S, 2015, HEPATOLOGY, V61, P1205, DOI 10.1002/hep.27544
   Parker HM, 2012, J HEPATOL, V56, P944, DOI 10.1016/j.jhep.2011.08.018
   Promrat K, 2010, HEPATOLOGY, V51, P121, DOI 10.1002/hep.23276
   Ratziu V, 2011, J HEPATOL, V54, P1011, DOI 10.1016/j.jhep.2010.08.030
   Ratziu V, 2010, HEPATOLOGY, V51, P445, DOI 10.1002/hep.23270
   Rouabhia S, 2014, EXPERT REV GASTROENT, V8, P343, DOI 10.1586/17474124.2014.894880
   Sanyal AJ, 2014, GASTROENTEROLOGY, V147, P377, DOI 10.1053/j.gastro.2014.04.046
   Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929
   Schauer PR, 2014, NEW ENGL J MED, V370, P2002, DOI 10.1056/NEJMoa1401329
   Schauer PR, 2012, NEW ENGL J MED, V366, P1567, DOI 10.1056/NEJMoa1200225
   Singh S, 2007, JAMA-J AM MED ASSOC, V298, P1189, DOI 10.1001/jama.298.10.1189
   Stephen S, 2012, EXPERT REV GASTROENT, V6, P163, DOI [10.1586/EGH.11.97, 10.1586/egh.11.97]
   Stienstra R, 2007, ENDOCRINOLOGY, V148, P2753, DOI 10.1210/en.2007-0014
   Thamer C, 2007, OBESITY, V15, P531, DOI 10.1038/oby.2007.568
   Torres DM, 2012, CLIN GASTROENTEROL H, V10, P837, DOI 10.1016/j.cgh.2012.03.011
   Unwin N, 2006, J ROY SOC MED, V99, P457, DOI 10.1258/jrsm.99.9.457
   Vilar-Gomez E, 2015, GASTROENTEROLOGY, V149, P367, DOI 10.1053/j.gastro.2015.04.005
   Yki-Jarvinen H, 2004, NEW ENGL J MED, V351, P1106, DOI 10.1056/NEJMra041001
   Younossi ZM, 2008, ALIMENT PHARM THER, V28, P2, DOI 10.1111/j.1365-2036.2008.03710.x
   Zaitone S, 2011, EUR J PHARMACOL, V662, P70, DOI 10.1016/j.ejphar.2011.04.049
   Zein CO, 2011, HEPATOLOGY, V54, P1610, DOI 10.1002/hep.24544
   Zeng T, 2014, EUR J GASTROEN HEPAT, V26, P646, DOI 10.1097/MEG.0000000000000068
NR 53
TC 11
Z9 13
U1 2
U2 7
PU ASSOC MEDICA BRASILEIRA
PI SAO PAULO
PA RUA SAO CARLOS DO PINHAL 324, CAIXA POSTAL 8904, SAO PAULO, SP, BRAZIL
EI 1806-9282
J9 REV ASSOC MED BRAS
JI Rev. Assoc. Med. Bras.
PD DEC
PY 2016
VL 62
IS 9
BP 872
EP 878
DI 10.1590/1806-9282.62.09.872
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EH4CN
UT WOS:000391718700015
PM 28001263
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Hulsmans, M
   De Keyzer, D
   Holvoet, P
AF Hulsmans, Maarten
   De Keyzer, Dieuwke
   Holvoet, Paul
TI MicroRNAs regulating oxidative stress and inflammation in relation to
   obesity and atherosclerosis
SO FASEB JOURNAL
LA English
DT Review
DE cardiovascular diseases; metabolic syndrome; vascular tissue; adipose
   tissue; microvesicles
ID C-REACTIVE PROTEIN; ADIPOSE-TISSUE MACROPHAGES; CORONARY-ARTERY-DISEASE;
   LOW-DENSITY-LIPOPROTEIN; ADIPOCYTE DIFFERENTIATION; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; GENE-EXPRESSION; ENDOTHELIAL DYSFUNCTION;
   CARDIOVASCULAR-DISEASE
AB A primary event in atherogenesis is the infiltration of activated inflammatory cells into the arterial wall. There they secrete reactive oxygen species and oxidize lipoproteins, inducing foam cell formation and endothelial cell apoptosis, which in turn lead to plaque growth, erosion, and rupture. In addition, there is evidence that this vicious circle between oxidative stress and inflammation occurs not only in the diseased arterial wall but also in adipose tissues in obesity. In this condition, oxidative stress and inflammation impair adipocyte maturation, resulting in defective insulin action and adipocytokine signaling. This observation raises questions regarding what molecules are probably common regulators of these pathogenic processes in adipose and vascular tissues. Candidates are small, noncoding, microRNAs (miRs) that control gene expression by inducing mRNA degradation or blocking translation. This review summarizes recent insights into the roles of miRs in regulation of oxidative stress and inflammation in vascular and adipose tissues. It emphasizes the role of miR-containing microvesicles in the interaction between inflammatory cells and endothelial cells within these tissues and in communication between these tissues, possibly explaining the similarity and the simultaneity of molecular changes and interactions in adipose and vascular tissues.-Hulsmans, M., De Keyzer, D., Holvoet, P. MicroRNAs regulating oxidative stress and inflammation in relation to obesity and atherosclerosis. FASEB J. 25, 2515-2527 (2011). www.fasebj.org
C1 [Hulsmans, Maarten; De Keyzer, Dieuwke; Holvoet, Paul] Katholieke Univ Leuven, Dept Cardiovasc Dis, Atherosclerosis & Metab Unit, B-3000 Louvain, Belgium.
C3 KU Leuven
RP Holvoet, P (corresponding author), Katholieke Univ Leuven, Dept Cardiovasc Dis, Atherosclerosis & Metab Unit, Herestr 49,O&N1,PB 705, B-3000 Louvain, Belgium.
EM paul.holvoet@med.kuleuven.be
RI HOLVOET, PAUL/T-8434-2017; Hulsmans, Maarten/AAI-9547-2020
OI Holvoet, Paul/0000-0001-9201-0772; Hulsmans, Maarten/0000-0003-1009-658X
FU Belgian Federal Government [P06/30]; Katholieke Universiteit Leuven
   [PF/10/014]; Fonds voor Wetenschappelijk Onderzoek-Vlaanderen
   [G.0846.11]
FX Funding was provided by the Interuniversitaire Attractiepolen Programma
   of the Belgian Federal Government (P06/30), the Bijzonder
   Onderzoeksfonds of the Katholieke Universiteit Leuven (PF/10/014), and
   the Fonds voor Wetenschappelijk Onderzoek-Vlaanderen (G.0846.11 and
   Vascular Biology Network).
CR Akao Y, 2011, MOL THER, V19, P395, DOI 10.1038/mt.2010.254
   Alevizos I, 2010, NAT REV RHEUMATOL, V6, P391, DOI 10.1038/nrrheum.2010.81
   Anand S, 2010, NAT MED, V16, P909, DOI 10.1038/nm.2186
   Andreasen D, 2010, METHODS, V50, pS6, DOI 10.1016/j.ymeth.2010.01.006
   Aoki N, 2010, ENDOCRINOLOGY, V151, P2567, DOI 10.1210/en.2009-1023
   Barbato C, 2009, J BIOMED BIOTECHNOL, DOI 10.1155/2009/803069
   Bartel DP, 2004, CELL, V116, P281, DOI 10.1016/S0092-8674(04)00045-5
   BASTIDA E, 1984, BLOOD, V64, P177
   Bonauer A, 2010, CURR DRUG TARGETS, V11, P943, DOI 10.2174/138945010791591313
   Bonauer A, 2009, SCIENCE, V324, P1710, DOI 10.1126/science.1174381
   Bordeleau ME, 2005, P NATL ACAD SCI USA, V102, P10460, DOI 10.1073/pnas.0504249102
   BORK S, 2010, J CELL PHYSL, DOI DOI 10.1002/JCP.22557
   Brennecke J, 2003, CELL, V113, P25, DOI 10.1016/S0092-8674(03)00231-9
   Buller B, 2010, FEBS J, V277, P4299, DOI 10.1111/j.1742-4658.2010.07818.x
   Butler J, 2006, J AM COLL CARDIOL, V47, P1595, DOI 10.1016/j.jacc.2005.12.046
   Ceolotto G, 2011, AM J HYPERTENS, V24, P241, DOI 10.1038/ajh.2010.211
   Chang CL, 2011, ENDOCRINOLOGY, V152, P384, DOI 10.1210/en.2010-0493
   Chen DL, 2010, J CELL PHYSIOL, V225, P296, DOI 10.1002/jcp.22234
   Chen T, 2009, CARDIOVASC RES, V83, P131, DOI 10.1093/cvr/cvp121
   Chen Y, 2010, MOL CELL BIOL, V30, P3902, DOI 10.1128/MCB.01237-09
   Cipolletta C, 2005, DIABETES, V54, P2779, DOI 10.2337/diabetes.54.9.2779
   Cocucci E, 2009, TRENDS CELL BIOL, V19, P43, DOI 10.1016/j.tcb.2008.11.003
   COLE JE, 2010, MEDIAT INFLAMM, P393
   Conen D, 2009, CIRCULATION, V120, P1041, DOI 10.1161/CIRCULATIONAHA.109.863092
   Cordes KR, 2009, NATURE, V460, P705, DOI 10.1038/nature08195
   Corsten MF, 2010, CIRC-CARDIOVASC GENE, V3, P499, DOI 10.1161/CIRCGENETICS.110.957415
   Czech MP, 2006, NEW ENGL J MED, V354, P1194, DOI 10.1056/NEJMcibr060065
   de Ferranti S, 2008, CLIN CHEM, V54, P945, DOI 10.1373/clinchem.2007.100156
   de Luca C, 2008, FEBS LETT, V582, P97, DOI 10.1016/j.febslet.2007.11.057
   DeClercq Vanessa, 2008, Cardiovascular & Hematological Disorders - Drug Targets, V8, P228, DOI 10.2174/187152908785849080
   Deng DJ, 2010, ADV GENET, V71, P125, DOI [10.1016/S0065-2660(10)71005-1, 10.1016/B978-0-12-380864-6.00005-5]
   Deng G, 2010, INT J OBESITY, V34, P165, DOI 10.1038/ijo.2009.205
   Dentelli P, 2010, ARTERIOSCL THROM VAS, V30, P1562, DOI 10.1161/ATVBAHA.110.206201
   Djuranovic S, 2011, SCIENCE, V331, P550, DOI 10.1126/science.1191138
   Dong SM, 2009, J BIOL CHEM, V284, P29514, DOI 10.1074/jbc.M109.027896
   Duncan BB, 2003, DIABETES, V52, P1799, DOI 10.2337/diabetes.52.7.1799
   Dyce PW, 2010, HISTOL HISTOPATHOL, V25, P505, DOI 10.14670/HH-25.505
   Eder C, 2009, IMMUNOBIOLOGY, V214, P543, DOI 10.1016/j.imbio.2008.11.007
   Ella L, 2009, CELL DEATH DIFFER, V16, P1590, DOI 10.1038/cdd.2009.153
   Estep M, 2010, ALIMENT PHARM THER, V32, P487, DOI 10.1111/j.1365-2036.2010.04366.x
   Fang Y, 2010, P NATL ACAD SCI USA, V107, P13450, DOI 10.1073/pnas.1002120107
   Fichtlscherer S, 2010, CIRC RES, V107, P677, DOI 10.1161/CIRCRESAHA.109.215566
   Fleissner F, 2010, CIRC RES, V107, P138, DOI 10.1161/CIRCRESAHA.110.216770
   Fonseca V, 2004, ENDOCR REV, V25, P153, DOI 10.1210/er.2002-0034
   Fontana L, 2007, NAT CELL BIOL, V9, P775, DOI 10.1038/ncb1613
   Forrest ARR, 2010, LEUKEMIA, V24, P460, DOI 10.1038/leu.2009.246
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gerin I, 2010, AM J PHYSIOL-ENDOC M, V299, pE198, DOI 10.1152/ajpendo.00179.2010
   Ghosh G, 2010, J CLIN INVEST, V120, P4141, DOI 10.1172/JCI42980
   Guo M, 2010, IMMUNOL CELL BIOL, V88, P555, DOI 10.1038/icb.2010.16
   Harris TA, 2008, P NATL ACAD SCI USA, V105, P1516, DOI 10.1073/pnas.0707493105
   He AB, 2007, MOL ENDOCRINOL, V21, P2785, DOI 10.1210/me.2007-0167
   Heilbronn LK, 2008, CURR PHARM DESIGN, V14, P1225, DOI 10.2174/138161208784246153
   Heneghan HM, 2010, OBES REV, V11, P354, DOI 10.1111/j.1467-789X.2009.00659.x
   Hennessy EJ, 2010, NAT REV DRUG DISCOV, V9, P293, DOI 10.1038/nrd3203
   Ho L, 2010, EXP GERONTOL, V45, P15, DOI 10.1016/j.exger.2009.09.007
   Holvoet P, 2004, DIABETES, V53, P1068, DOI 10.2337/diabetes.53.4.1068
   Holvoet P, 2008, JAMA-J AM MED ASSOC, V299, P2287, DOI 10.1001/jama.299.19.2287
   Horie T, 2010, P NATL ACAD SCI USA, V107, P17321, DOI 10.1073/pnas.1008499107
   Huang RS, 2010, J INVEST MED, V58, P961, DOI 10.231/JIM.0b013e3181ff46d7
   Hulsmans M, 2010, J CELL MOL MED, V14, P70, DOI 10.1111/j.1582-4934.2009.00978.x
   Hunter MP, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003694
   Ito T, 2010, BIOCHEM BIOPH RES CO, V398, P735, DOI 10.1016/j.bbrc.2010.07.012
   Ji RR, 2007, CIRC RES, V100, P1579, DOI 10.1161/CIRCRESAHA.106.141986
   Karbiener M, 2009, BIOCHEM BIOPH RES CO, V390, P247, DOI 10.1016/j.bbrc.2009.09.098
   Kartha RV, 2010, J CARDIOVASC TRANSL, V3, P256, DOI 10.1007/s12265-010-9172-z
   Keophiphath M, 2009, MOL ENDOCRINOL, V23, P11, DOI 10.1210/me.2008-0183
   Kim SY, 2010, BIOCHEM BIOPH RES CO, V392, P323, DOI 10.1016/j.bbrc.2010.01.012
   Kim YJ, 2009, STEM CELLS, V27, P3093, DOI 10.1002/stem.235
   Kinoshita M, 2010, MOL ENDOCRINOL, V24, P1978, DOI 10.1210/me.2010-0054
   Klöting N, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004699
   Kota J, 2009, CELL, V137, P1005, DOI 10.1016/j.cell.2009.04.021
   Krützfeldt J, 2005, NATURE, V438, P685, DOI 10.1038/nature04303
   Kuehbacher A, 2007, CIRC RES, V101, P59, DOI 10.1161/CIRCRESAHA.107.153916
   Lee EK, 2011, MOL CELL BIOL, V31, P626, DOI 10.1128/MCB.00894-10
   Leeper NJ, 2011, J CELL PHYSIOL, V226, P1035, DOI 10.1002/jcp.22422
   Li GX, 2011, J CELL BIOCHEM, V112, P1318, DOI 10.1002/jcb.23045
   Lia D, 2010, J HYPERTENS, V28, P1646, DOI 10.1097/HJH.0b013e32833a4922
   Lin Q, 2009, FEBS J, V276, P2348, DOI 10.1111/j.1742-4658.2009.06967.x
   Lin Y, 2009, J BIOL CHEM, V284, P7903, DOI 10.1074/jbc.M806920200
   Ling C, 2009, DIABETES, V58, P2718, DOI 10.2337/db09-1003
   Ling HY, 2009, CLIN EXP PHARMACOL P, V36, pe32, DOI 10.1111/j.1440-1681.2009.05207.x
   Löffler D, 2007, BLOOD, V110, P1330, DOI 10.1182/blood-2007-03-081133
   Lumeng CN, 2007, J CLIN INVEST, V117, P175, DOI 10.1172/JCI29881
   Lumeng CN, 2008, DIABETES, V57, P3239, DOI 10.2337/db08-0872
   Luo NL, 2010, DIABETES, V59, P791, DOI 10.2337/db09-1338
   Marquart TJ, 2010, P NATL ACAD SCI USA, V107, P12228, DOI 10.1073/pnas.1005191107
   Martin MM, 2007, J BIOL CHEM, V282, P24262, DOI 10.1074/jbc.M701050200
   Mathivanan S, 2010, MOL CELL PROTEOMICS, V9, P197, DOI 10.1074/mcp.M900152-MCP200
   Matkovich SJ, 2009, CIRCULATION, V119, P1263, DOI 10.1161/CIRCULATIONAHA.108.813576
   Mause SF, 2010, CIRC RES, V107, P1047, DOI 10.1161/CIRCRESAHA.110.226456
   Menghini R, 2009, CIRCULATION, V120, P1524, DOI 10.1161/CIRCULATIONAHA.109.864629
   Nakamachi Y, 2009, ARTHRITIS RHEUM-US, V60, P1294, DOI 10.1002/art.24475
   Ndumele Chiadi E, 2006, J Cardiometab Syndr, V1, P190
   O'Connell RM, 2007, P NATL ACAD SCI USA, V104, P1604, DOI 10.1073/pnas.0610731104
   Ogawa R, 2010, BIOCHEM BIOPH RES CO, V398, P723, DOI 10.1016/j.bbrc.2010.07.008
   Ohashi K, 2010, J BIOL CHEM, V285, P6153, DOI 10.1074/jbc.M109.088708
   Ohtani K, 2011, BASIC RES CARDIOL, V106, P5, DOI 10.1007/s00395-010-0139-7
   Olsen PH, 1999, DEV BIOL, V216, P671, DOI 10.1006/dbio.1999.9523
   Orom UA, 2006, GENE, V372, P137, DOI 10.1016/j.gene.2005.12.031
   Ortega FJ, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009022
   Pamukcu B, 2010, ANN MED, V42, P394, DOI 10.3109/07853890.2010.497767
   Park K, 2009, DIABETES CARE, V32, P1302, DOI 10.2337/dc09-0259
   Parra P, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013005
   Peña AS, 2010, INT J PEDIATR OBES, V5, P185, DOI 10.3109/17477160903111748
   Phalon C, 2010, EXPERT REV MOL MED, V12, DOI 10.1017/S1462399410001584
   Ploner A, 2009, RNA, V15, P1797, DOI 10.1261/rna.1740009
   Poliseno L, 2006, BLOOD, V108, P3068, DOI 10.1182/blood-2006-01-012369
   Poller W, 2010, CARDIOVASC RES, V86, P353, DOI 10.1093/cvr/cvq056
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Prieur X, 2011, DIABETES, V60, P797, DOI 10.2337/db10-0705
   Ran JM, 2010, DIABETES RES CLIN PR, V88, P177, DOI 10.1016/j.diabres.2010.01.021
   Rayner KJ, 2010, SCIENCE, V328, P1570, DOI 10.1126/science.1189862
   Reilly MP, 2005, CIRCULATION, V111, P932, DOI 10.1161/01.CIR.0000155620.10387.43
   Ribas J, 2010, CELL CYCLE, V9, P923, DOI 10.4161/cc.9.5.10930
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   Ronald JA, 2009, CIRCULATION, V120, P592, DOI 10.1161/CIRCULATIONAHA.108.813998
   Rosa A, 2007, P NATL ACAD SCI USA, V104, P19849, DOI 10.1073/pnas.0706963104
   Sayed D, 2010, J BIOL CHEM, V285, P20281, DOI 10.1074/jbc.M110.109207
   Sethi JK, 2007, J LIPID RES, V48, P1253, DOI 10.1194/jlr.R700005-JLR200
   Shaked I, 2009, IMMUNITY, V31, P965, DOI 10.1016/j.immuni.2009.09.019
   Shibata SI, 2009, INT J ONCOL, V34, P1433, DOI 10.3892/ijo_00000272
   Simak J, 2006, TRANSFUS MED REV, V20, P1, DOI 10.1016/j.tmrv.2005.08.001
   Skog J, 2008, NAT CELL BIOL, V10, P1470, DOI 10.1038/ncb1800
   Strum JC, 2009, MOL ENDOCRINOL, V23, P1876, DOI 10.1210/me.2009-0117
   Sun TW, 2009, MOL ENDOCRINOL, V23, P925, DOI 10.1210/me.2008-0298
   Takahashi Y, 2010, CLIN SCI, V119, P395, DOI 10.1042/CS20100003
   Tsimikas S, 2006, J AM COLL CARDIOL, V47, pC19, DOI 10.1016/j.jacc.2005.10.066
   Tuccoli A, 2006, CELL CYCLE, V5, P2473, DOI 10.4161/cc.5.21.3422
   van Rooij E, 2011, CIRC RES, V108, P219, DOI 10.1161/CIRCRESAHA.110.227496
   Vickers Kasey C, 2010, Curr Opin Endocrinol Diabetes Obes, V17, P150, DOI 10.1097/MED.0b013e32833727a1
   Villeneuve LM, 2010, DIABETES, V59, P2904, DOI 10.2337/db10-0208
   Wang Q, 2008, P NATL ACAD SCI USA, V105, P2889, DOI 10.1073/pnas.0800178105
   Wang XH, 2010, CIRCULATION, V122, P1308, DOI 10.1161/CIRCULATIONAHA.110.964684
   Weber M, 2010, BIOCHEM BIOPH RES CO, V393, P643, DOI 10.1016/j.bbrc.2010.02.045
   Wong P, 2010, CANCER RES, V70, P3833, DOI 10.1158/0008-5472.CAN-09-3268
   Xie HM, 2009, DIABETES, V58, P1050, DOI 10.2337/db08-1299
   Yang Z, 2011, STEM CELLS DEV, V20, P259, DOI 10.1089/scd.2010.0072
   Yudkin JS, 2000, ATHEROSCLEROSIS, V148, P209, DOI 10.1016/S0021-9150(99)00463-3
   Zampetaki A, 2010, CIRC RES, V107, P810, DOI 10.1161/CIRCRESAHA.110.226357
   Zernecke A, 2009, SCI SIGNAL, V2, DOI 10.1126/scisignal.2000610
   Zhang YJ, 2010, MOL CELL, V39, P133, DOI 10.1016/j.molcel.2010.06.010
   Zheng LA, 2010, BIOCHEM BIOPH RES CO, V400, P483, DOI 10.1016/j.bbrc.2010.08.067
   Zhu N, 2011, ATHEROSCLEROSIS, V215, P286, DOI 10.1016/j.atherosclerosis.2010.12.024
NR 144
TC 196
Z9 221
U1 1
U2 31
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD AUG
PY 2011
VL 25
IS 8
BP 2515
EP 2527
DI 10.1096/fj.11-181149
PG 13
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 800CV
UT WOS:000293337800003
PM 21507901
DA 2025-06-11
ER

PT J
AU Berenbaum, F
AF Berenbaum, Francis
TI Diabetes-induced osteoarthritis: from a new paradigm to a new phenotype
SO ANNALS OF THE RHEUMATIC DISEASES
LA English
DT Article
ID GLYCATION END-PRODUCTS; METABOLIC SYNDROME; GLUCOSE-TRANSPORT; OXIDATIVE
   STRESS; KNEE; CHONDROCYTES; HYPERGLYCEMIA; ACTIVATION; CARTILAGE;
   RECEPTOR
AB Several epidemiological and experimental data support the hypothesis that diabetes could be an independent risk factor for osteoarthritis (OA), at least in some patients, leading to the concept of a diabetes-induced OA phenotype. If confirmed, this new paradigm will have a dramatic impact on prevention of OA initiation and progression.
C1 Univ Paris 06, St Antoine Hosp, APHP, Dept Rheumatol, Paris, France.
C3 Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Hotel-Dieu - APHP; Hopital Universitaire
   Ambroise-Pare - APHP; Sorbonne Universite; Hopital Universitaire
   Saint-Antoine - APHP
RP Berenbaum, F (corresponding author), Univ Paris 06, St Antoine Hosp, APHP, Dept Rheumatol, Paris, France.
EM francis.berenbaum@sat.aphp.fr
RI Berenbaum, Francis/AAO-5690-2020
OI berenbaum, francis/0000-0001-8252-7815
CR ANDERSON JJ, 1988, AM J EPIDEMIOL, V128, P179, DOI 10.1093/oxfordjournals.aje.a114939
   Atayde SA, 2010, ARTHRITIS RHEUM S10, V62, pS368
   BROWNLEE M, 1988, NEW ENGL J MED, V318, P1315
   Cadwell BL., 2010, J Data Sci, V8, P173
   Cecil DL, 2005, J IMMUNOL, V175, P8296, DOI 10.4049/jimmunol.175.12.8296
   CIMMINO MA, 1990, CLIN EXP RHEUMATOL, V8, P251
   Engström G, 2009, OSTEOARTHR CARTILAGE, V17, P168, DOI 10.1016/j.joca.2008.07.003
   Esposito K, 2002, CIRCULATION, V106, P2067, DOI 10.1161/01.CIR.0000034509.14906.AE
   Frey MI, 1996, J RHEUMATOL, V23, P716
   HART DJ, 1995, J RHEUMATOL, V22, P1118
   Henrotin YE, 2003, OSTEOARTHR CARTILAGE, V11, P747, DOI 10.1016/S1063-4584(03)00150-X
   Herrero-Beaumont G, 2009, SEMIN ARTHRITIS RHEU, V39, P71, DOI 10.1016/j.semarthrit.2009.03.006
   Hurley MV, 1999, RHEUM DIS CLIN N AM, V25, P283, DOI 10.1016/S0889-857X(05)70068-5
   Igarashi M, 1999, J CLIN INVEST, V103, P185, DOI 10.1172/JCI3326
   KELLEY KM, 1993, DIABETES, V42, P463, DOI 10.2337/diabetes.42.3.463
   Ling PR, 2003, METABOLISM, V52, P868, DOI 10.1016/S0026-0495(03)00057-X
   Loeser RF, 2005, ARTHRITIS RHEUM, V52, P2376, DOI 10.1002/art.21199
   MAROUDAS A, 1968, Journal of Bone and Joint Surgery British Volume, V50B, P166
   McNulty AL, 2005, ARTHRITIS RHEUM-US, V52, P2676, DOI 10.1002/art.21254
   Mobasheri A, 2008, ADV ANAT EMBRYOL CEL, V200, P1
   Pottie P, 2006, ANN RHEUM DIS, V65, P1403, DOI 10.1136/ard.2006.061994
   Puenpatom RA, 2009, POSTGRAD MED, V121, P9, DOI 10.3810/pgm.2009.11.2073
   Ramasamy R, 2005, GLYCOBIOLOGY, V15, p16R, DOI 10.1093/glycob/cwi053
   Rosa SC, 2009, ARTHRITIS RES THER, V11, DOI 10.1186/ar2713
   Schett G, 2009, ARTHRITIS RHEUM-US, V60, P2381, DOI 10.1002/art.24757
   Shakoor N, 2008, ARTHRIT RHEUM-ARTHR, V59, P1237, DOI 10.1002/art.24004
   Shikhman AR, 2001, J IMMUNOL, V167, P7001, DOI 10.4049/jimmunol.167.12.7001
   Slemenda C, 1997, ANN INTERN MED, V127, P97, DOI 10.7326/0003-4819-127-2-199707150-00001
   Stannus O, 2010, OSTEOARTHR CARTILAGE, V18, P1441, DOI 10.1016/j.joca.2010.08.016
   Steenvoorden MMC, 2006, ARTHRITIS RHEUM-US, V54, P253, DOI 10.1002/art.21523
   Stürmer T, 2001, SCAND J RHEUMATOL, V30, P169
   van Sloten TT, 2011, DIABETES RES CLIN PR, V91, P32, DOI 10.1016/j.diabres.2010.09.030
   Velasquez MT, 2010, METAB SYNDR RELAT D, V8, P295, DOI 10.1089/met.2009.0110
   Verzijl N, 2002, ARTHRITIS RHEUM, V46, P114, DOI 10.1002/1529-0131(200201)46:1<114::AID-ART10025>3.0.CO;2-P
   WAINE H, 1961, Tufts Folia Med, V7, P13
   Yan SF, 2010, CIRC RES, V106, P842, DOI 10.1161/CIRCRESAHA.109.212217
   Yerneni KKV, 1999, DIABETES, V48, P855, DOI 10.2337/diabetes.48.4.855
NR 37
TC 122
Z9 134
U1 1
U2 23
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0003-4967
EI 1468-2060
J9 ANN RHEUM DIS
JI Ann. Rheum. Dis.
PD AUG
PY 2011
VL 70
IS 8
BP 1354
EP 1356
DI 10.1136/ard.2010.146399
PG 3
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 784WC
UT WOS:000292188100002
PM 21474484
DA 2025-06-11
ER

PT J
AU Yu, BB
   Zhang, XY
   Wang, CP
   Sun, MZ
   Jin, LN
   Liu, X
AF Yu, Binbin
   Zhang, Xueyuan
   Wang, Chunpeng
   Sun, Mengzi
   Jin, Lina
   Liu, Xin
TI Trends in depression among Adults in the United States, NHANES 2005-2016
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Trends; Risk factor; NHANES
ID QUALITY-OF-LIFE; GENDER-DIFFERENCES; METABOLIC SYNDROME;
   MENTAL-DISORDERS; NATIONAL-HEALTH; PREVALENCE; EPIDEMIOLOGY;
   HYPERTENSION; ASSOCIATION; SYMPTOMS
AB Objectives: To describe the prevalence and trends of mild, moderate and severe depression among adults and all age groups in the US from 2005 to 2016, and analysis the risk factors for depression.
   Methods: This study analyzed the prevalence and association with risk factors of depression using weighted univariate logistic regression model. Data of NHANES 2005-2016 were used.
   Results: This study analyzed 29,303 participants. From 2005 through 2016, the trends of severe depression increased among >= 20 years (p for trend = 0.026, difference, 0.109[0.012,0.207]); severe depression increased among >= 65 years (p for trend <0.001, difference, 0.302[0.170,0.435]); and moderate depression increased among 20-39 years (p for trend = 0.028, difference, 0.137[0.045,0.229]). In adults, the odds ratios (OR)(95% confidence intervals (CI)) of mild depression for < 25000$ was 2.24 (1.96, 2.55), moderate depression was 4.94(3.91,6.24), and severe depression was 6.45(4.78,8.71); the OR(95%CI) of mild depression for smoking was 1.69(1.55,1.84), moderate depression was 2.94(2.57,3.35), and severe depression was 3.36(2.87,3.93); the OR (95%CI) of mild depression for hypertension was1.27(1.18,1.38), moderate depression was1.50(1.31,1.73), and severe depression was 1.94(1.61,2.34); the OR(95%CI) of mild depression for diabetes mellitus was1.45(1.30,1.61), moderate depression was1.83(1.51,2.22), and severe depression was 2.05(1.70,2.48).
   Conclusions: There was an increasing trend of severe depression in American adults, which was mainly manifested in the increasing trend of severe depression in the population >= 65 years. And the trend of moderate depression increased in 20-39 years. In addition, lower income, smoking, hypertension and diabetes mellitus increased the risk of depression, and the risk increased with the degree of depression.
C1 [Yu, Binbin; Zhang, Xueyuan; Sun, Mengzi; Jin, Lina; Liu, Xin] Jilin Univ, Sch Publ Hlth, Dept Epidemiol & Stat, Changchun 130021, Peoples R China.
   [Wang, Chunpeng] Northeast Normal Univ, Sch Math & Stat, Changchun, Jilin, Peoples R China.
C3 Jilin University; Northeast Normal University - China
RP Jin, LN; Liu, X (corresponding author), Jilin Univ, Sch Publ Hlth, Dept Epidemiol & Stat, Changchun 130021, Peoples R China.
EM jinln@jlu.edu.cn; liuxinjlu01@163.com
RI jin, lina/KRO-4922-2024
OI Sun, Mengzi/0000-0001-8001-8064
FU National Key Research and Development Program of China [2017YFC0108602]
FX This work was supported by The National Key Research and Development
   Program of China [grant number 2017YFC0108602].
CR Al-Ibrahim AA, 2019, NUTR J, V18, DOI 10.1186/s12937-019-0450-6
   Andrea SB, 2016, GEN HOSP PSYCHIAT, V39, P73, DOI 10.1016/j.genhosppsych.2015.11.009
   [Anonymous], PSYCHIAT DANUB S4
   Beals J, 2005, AM J PSYCHIAT, V162, P1713, DOI 10.1176/appi.ajp.162.9.1713
   Blazer DG, 2003, J GERONTOL A-BIOL, V58, P249
   Booth JN, 2017, HYPERTENSION, V70, P275, DOI 10.1161/HYPERTENSIONAHA.116.09004
   Cui RJ, 2015, CURR NEUROPHARMACOL, V13, P480, DOI 10.2174/1570159X1304150831123535
   Cuijpers P, 2014, AM J PSYCHIAT, V171, P453, DOI 10.1176/appi.ajp.2013.13030325
   Curtin Lester R, 2013, Vital Health Stat 2, P1
   Fain JA, 2017, DIABETES EDUCATOR, V43, P151, DOI 10.1177/0145721717698651
   Faith MS, 2011, OBES REV, V12, pe438, DOI 10.1111/j.1467-789X.2010.00843.x
   Feng L, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0114139
   Fluharty M, 2017, NICOTINE TOB RES, V19, P3, DOI 10.1093/ntr/ntw140
   Gero K, 2017, SOC SCI MED, V189, P138, DOI 10.1016/j.socscimed.2017.07.028
   Gilman SE, 2017, CAN MED ASSOC J, V189, pE1304, DOI 10.1503/cmaj.170125
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hasin DS, 2005, ARCH GEN PSYCHIAT, V62, P1097, DOI 10.1001/archpsyc.62.10.1097
   Jeuring HW, 2018, PSYCHOL MED, V48, P1824, DOI 10.1017/S0033291717003324
   Jim HSL, 2012, ANN BEHAV MED, V43, P402, DOI 10.1007/s12160-011-9333-6
   Kawachi I, 2002, J EPIDEMIOL COMMUN H, V56, P647, DOI 10.1136/jech.56.9.647
   Klinitzke G, 2013, J AFFECT DISORDERS, V145, P277, DOI 10.1016/j.jad.2012.07.010
   Kouwenhoven SE, 2011, DISABIL REHABIL, V33, P539, DOI 10.3109/09638288.2010.505997
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Kroenke K, 2010, GEN HOSP PSYCHIAT, V32, P345, DOI 10.1016/j.genhosppsych.2010.03.006
   Kuehner C, 2003, ACTA PSYCHIAT SCAND, V108, P163, DOI 10.1034/j.1600-0447.2003.00204.x
   Li ZZ, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000001317
   Lôo H, 2004, B ACAD NAT MED PARIS, V188, P999, DOI 10.1016/S0001-4079(19)33716-1
   Maatouk I, 2016, J HYPERTENS, V34, P1711, DOI 10.1097/HJH.0000000000001006
   Marmot M, 2001, BMJ-BRIT MED J, V322, P1233, DOI 10.1136/bmj.322.7296.1233
   Martínez-Pérez B, 2013, J MED INTERNET RES, V15, DOI 10.2196/jmir.2600
   Mirel Lisa B, 2013, Vital Health Stat 2, P1
   Mirkena Y, 2018, BMC PSYCHIATRY, V18, DOI 10.1186/s12888-018-1911-8
   Overbeek G, 2006, J FAM PSYCHOL, V20, P284, DOI 10.1037/0893-3200.20.2.284
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Piccinelli M, 2000, BRIT J PSYCHIAT, V177, P486, DOI 10.1192/bjp.177.6.486
   Roy T, 2012, J AFFECT DISORDERS, V142, pS8, DOI 10.1016/S0165-0327(12)70004-6
   Scott KM, 2008, INT J OBESITY, V32, P192, DOI 10.1038/sj.ijo.0803701
   Sivertsen H, 2015, DEMENT GERIATR COGN, V40, P311, DOI 10.1159/000437299
   Smith Kerri, 2014, Nature, V515, P181, DOI 10.1038/515180a
   Spitzer RL, 1999, JAMA-J AM MED ASSOC, V282, P1737, DOI 10.1001/jama.282.18.1737
   Stewart JC, 2012, CIRCULATION, V126, P410, DOI 10.1161/CIRCULATIONAHA.112.094946
   Subramanian SV, 2006, HEALTH PLACE, V12, P141, DOI 10.1016/j.healthplace.2004.11.001
   Teo AR, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0062396
   Walker ER, 2015, JAMA PSYCHIAT, V72, P334, DOI 10.1001/jamapsychiatry.2014.2502
   Weinberger AH, 2018, PSYCHOL MED, V48, P1308, DOI [10.1017/S0033291717002781, 10.1017/s0033291717002781]
   Weir CB., 2019, StatPearls
   WEISSMAN MM, 1977, ARCH GEN PSYCHIAT, V34, P98
   Whisman MA, 1999, J ABNORM PSYCHOL, V108, P674, DOI 10.1037/0021-843X.108.4.674
   Zallman L, 2013, J IMMIGR MINOR HEALT, V15, P858, DOI 10.1007/s10903-012-9695-2
   Zhang NN, 2017, J INT MED RES, V45, P594, DOI 10.1177/0300060517693178
NR 50
TC 80
Z9 90
U1 10
U2 74
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD FEB 15
PY 2020
VL 263
BP 609
EP 620
DI 10.1016/j.jad.2019.11.036
PG 12
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA KE9MP
UT WOS:000508874400081
PM 31744739
DA 2025-06-11
ER

PT J
AU Kim, H
   Kang, S
   Go, GW
AF Kim, Hayoon
   Kang, Sumin
   Go, Gwang-woong
TI Black beans (Glycine max (L.) Merrill) included in a multi-grain
   rice reduce total cholesterol and enhance antioxidant capacity in
   high-fat diet-induced obese mice
SO FOOD SCIENCE AND BIOTECHNOLOGY
LA English
DT Article
DE Antioxidant; Black bean; Body composition; Dyslipidemia; Growth
   performance; Obesity
ID OXIDATIVE STRESS; METABOLIC SYNDROME; RECEPTOR; MUSCLE
AB This study investigated the effects of black bean (BB) supplementation on the growth performance, lipid metabolism, and antioxidant capacity of high-fat diet-induced obese mice. The results demonstrated that although the inclusion of BBs led to increased body weight, total energy intake, and feed efficiency ratio, it did not significantly alter the overall body composition, including adiposity. Notably, BB consumption reduced total cholesterol levels, suggesting its potential to manage dyslipidemia and reduce the risk of atherosclerotic cardiovascular diseases. Furthermore, BBs significantly enhanced in the total antioxidant capacity, as indicated by the notable increase in both the total antioxidant capacity and superoxide dismutase activity. These findings provide significant insights into the promising health benefits of BBs in the context of metabolic syndrome and related health complications.
C1 [Kim, Hayoon; Kang, Sumin; Go, Gwang-woong] Hanyang Univ, Dept Food & Nutr, Seoul 04763, South Korea.
C3 Hanyang University
RP Go, GW (corresponding author), Hanyang Univ, Dept Food & Nutr, Seoul 04763, South Korea.
EM kimhayoon0408@gmail.com; sumin.kang708@gmail.com; gwgo1015@hanyang.ac.kr
RI Go, Gwang-woong/AGM-4417-2022
OI Go, Gwang-woong/0000-0002-3848-8705
FU Cuchen [202200000000711]; Cuchen Co., Ltd.
FX This research was supported by Cuchen Co., Ltd. (202200000000711).
CR Bhatti Jasvinder Singh, 2017, Biochim Biophys Acta Mol Basis Dis, V1863, P1066, DOI 10.1016/j.bbadis.2016.11.010
   Byun JS, 2010, INT J VITAM NUTR RES, V80, P97, DOI 10.1024/0300-9831/a000010
   Chang TY, 2006, ANNU REV CELL DEV BI, V22, P129, DOI 10.1146/annurev.cellbio.22.010305.104656
   Chong Hee Sun, 2017, [Journal of Food Hygiene and Safety, 한국식품위생안전성학회지], V32, P521, DOI 10.13103/JFHS.2017.32.6.521
   Clemente TE, 2009, PLANT PHYSIOL, V151, P1030, DOI 10.1104/pp.109.146282
   DAHEE KIM, 2020, [Journal of the Korean Society of Food Science and Nutrition, 한국식품영양과학회지], V49, P1236
   Darenskaya MA, 2021, B EXP BIOL MED+, V171, P179, DOI 10.1007/s10517-021-05191-7
   Erel O, 2004, CLIN BIOCHEM, V37, P277, DOI 10.1016/j.clinbiochem.2003.11.015
   Filomeni G, 2015, CELL DEATH DIFFER, V22, P377, DOI 10.1038/cdd.2014.150
   Ganesan K, 2017, NUTRIENTS, V9, DOI 10.3390/nu9050455
   Gesquière L, 1999, FREE RADICAL BIO MED, V27, P134, DOI 10.1016/S0891-5849(99)00055-6
   Ginsberg HN, 2006, OBESITY, V14, p41S, DOI 10.1038/oby.2006.281
   Go GW, 2014, CELL METAB, V19, P209, DOI 10.1016/j.cmet.2013.11.023
   Go Gwang-woong, 2012, Yale Journal of Biology and Medicine, V85, P19
   Han SH, 2006, J NUTR BIOCHEM, V17, P682, DOI 10.1016/j.jnutbio.2005.11.004
   Hayes John D, 2020, Cancer Cell, V38, P167, DOI 10.1016/j.ccell.2020.06.001
   Hernandez-Velazquez I, 2020, FOOD FUNCT, V11, P10341, DOI [10.1039/d0fo02258f, 10.1039/D0FO02258F]
   Hill JO, 2012, CIRCULATION, V126, P126, DOI 10.1161/CIRCULATIONAHA.111.087213
   Incalza MA, 2018, VASC PHARMACOL, V100, P1, DOI 10.1016/j.vph.2017.05.005
   Jeong EW, 2021, FOODS, V10, DOI 10.3390/foods10071571
   Jin CL, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8121549
   Kan LJ, 2018, FOOD CHEM, V260, P317, DOI 10.1016/j.foodchem.2018.03.148
   Kattoor AJ, 2017, CURR ATHEROSCLER REP, V19, DOI 10.1007/s11883-017-0678-6
   Keramati AR, 2014, NEW ENGL J MED, V370, P1909, DOI 10.1056/NEJMoa1301824
   전연희, 2011, [Korean Journal of Food and Cookery Science, 한국식품조리과학회지], V27, P1
   Kumar V, 2010, FOOD RES INT, V43, P323, DOI 10.1016/j.foodres.2009.10.019
   Luo J, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10020283
   Márquez-Mota CC, 2016, NUTRIENTS, V8, DOI 10.3390/nu8090573
   Marseglia L, 2015, INT J MOL SCI, V16, P378, DOI 10.3390/ijms16010378
   Matsukawa T, 2015, J NUTR BIOCHEM, V26, P860, DOI 10.1016/j.jnutbio.2015.03.006
   MAZESS RB, 1990, AM J CLIN NUTR, V51, P1106, DOI 10.1093/ajcn/51.6.1106
   Ngamsamer C, 2022, BIOMOLECULES, V12, DOI 10.3390/biom12060852
   Oh HG, 2014, J MED FOOD, V17, P972, DOI 10.1089/jmf.2012.2740
   Oliveira-Marques V, 2009, ANTIOXID REDOX SIGN, V11, P2223, DOI [10.1089/ars.2009.2601, 10.1089/ARS.2009.2601]
   Park SoYoung Park SoYoung, 2015, Journal of Nutrition and Health, V48, P299, DOI 10.4163/jnh.2015.48.4.299
   Raal FJ, 2009, METAB SYNDR RELAT D, V7, P83, DOI 10.1089/met.2008.0079
   Ryu D, 2022, FOOD SCI BIOTECHNOL, V31, P1053, DOI 10.1007/s10068-022-01071-6
   Sato T, 2015, J AGR FOOD CHEM, V63, P8192, DOI 10.1021/acs.jafc.5b03811
   Scalbert A, 2005, AM J CLIN NUTR, V81, p215S, DOI 10.1093/ajcn/81.1.215S
   Sosa V, 2013, AGEING RES REV, V12, P376, DOI 10.1016/j.arr.2012.10.004
   Stagos D, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9010019
   Sun MB, 2022, FOOD FUNCT, V13, P7377, DOI [10.1039/D2FO01165D, 10.1039/d2fo01165d]
   Tan YQ, 2021, FOODS, V10, DOI 10.3390/foods10081691
   Tsutsumi K, 2001, BIOL PHARM BULL, V24, P579, DOI 10.1248/bpb.24.579
   Wang JY, 2015, EXP THER MED, V9, P43, DOI 10.3892/etm.2014.2040
   Yamashita Y, 2020, FOOD FUNCT, V11, P7321, DOI [10.1039/d0fo01092h, 10.1039/D0FO01092H]
   Yang QQ, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-01555-0
   Yook JS, 2017, J MED FOOD, V20, P367, DOI 10.1089/jmf.2016.3821
NR 49
TC 0
Z9 1
U1 0
U2 6
PU KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
PI SEOUL
PA #605, KOREA SCI TECHNOL CENT, 635-4 YEOKSAM-DONG, KANGNAM-GU, SEOUL,
   135-703, SOUTH KOREA
SN 1226-7708
EI 2092-6456
J9 FOOD SCI BIOTECHNOL
JI Food Sci. Biotechnol.
PD SEP
PY 2024
VL 33
IS 12
BP 2857
EP 2864
DI 10.1007/s10068-024-01533-z
EA FEB 2024
PG 8
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA D6K3Z
UT WOS:001171640100001
PM 39184995
OA Green Published
DA 2025-06-11
ER

PT S
AU Carr, RM
   Correnti, J
AF Carr, Rotonya M.
   Correnti, Jason
BE Powers, AC
   Ahima, RS
TI Insulin resistance in clinical and experimental alcoholic liver disease
SO YEAR IN DIABETES AND OBESITY
SE Annals of the New York Academy of Sciences
LA English
DT Article; Book Chapter
DE alcoholic liver disease; insulin resistance; metabolic syndrome;
   NAFLD/NASH; steatohepatitis
ID ENDOPLASMIC-RETICULUM STRESS; DIETARY SATURATED FAT; CHRONIC ETHANOL;
   PROTEIN-KINASE; METABOLIC SYNDROME; HEPATIC STEATOSIS; PROTECTIVE
   ACTION; GUT LEAKINESS; NONALCOHOLIC STEATOHEPATITIS; INTRAGASTRIC
   INFUSION
AB Alcoholic liver disease (ALD) is the number one cause of liver failure worldwide; its management costs billions of healthcare dollars annually. Since the advent of the obesity epidemic, insulin resistance (IR) and diabetes have become common clinical findings in patients with ALD; and the development of IR predicts the progression from simple steatosis to cirrhosis in ALD patients. Both clinical and experimental data implicate the impairment of several mediators of insulin signaling in ALD, and experimental data suggest that insulin-sensitizing therapies improve liver histology. This review explores the contribution of impaired insulin signaling in ALD and summarizes the current understanding of the synergistic relationship between alcohol and nutrient excess in promoting hepatic inflammation and disease.
C1 [Carr, Rotonya M.; Correnti, Jason] Univ Penn, Dept Med, Div Gastroenterol, Perelman Sch Med, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania
RP Carr, RM (corresponding author), Univ Penn, Dept Med, Div Gastroenterol, Perelman Sch Med, 907 Biomed Res Bldg 2-3,421 Curie Blvd, Philadelphia, PA 19104 USA.
EM Rotonya.Carr@uphs.upenn.edu
FU NIAAA NIH HHS [K08-AA021424, K08 AA021424] Funding Source: Medline;
   NIDDK NIH HHS [P30 DK019525, P30 DK050306, P30-DK-50306] Funding Source:
   Medline
CR Adachi M, 2007, GASTROENTEROLOGY, V132, P1434, DOI 10.1053/j.gastro.2007.01.033
   Ahima RS, 2008, FRONT HORM RES, V36, P182, DOI 10.1159/000115365
   Ahima RS, 2000, ANNU REV PHYSIOL, V62, P413, DOI 10.1146/annurev.physiol.62.1.413
   Ajmo JM, 2008, AM J PHYSIOL-GASTR L, V295, pG833, DOI 10.1152/ajpgi.90358.2008
   Alkerwi A, 2009, ATHEROSCLEROSIS, V204, P624, DOI 10.1016/j.atherosclerosis.2008.10.036
   Alwahsh SM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0104220
   Anania FA, 1999, ALCOHOL CLIN EXP RES, V23, P279
   [Anonymous], 2009, J PHARMACOL EXP THER, DOI DOI 10.1124/jpet.108.148643
   Banerjee K, 1998, ALCOHOL CLIN EXP RES, V22, P2093, DOI 10.1097/00000374-199812000-00028
   Basantani MK, 2011, J LIPID RES, V52, P318, DOI 10.1194/jlr.M011205
   Bergheim I, 2006, GASTROENTEROLOGY, V130, P2099, DOI 10.1053/j.gastro.2006.03.020
   Bergheim I, 2011, ANN NY ACAD SCI, V1216, P41, DOI 10.1111/j.1749-6632.2010.05833.x
   BHAVANI K, 1995, ALCOHOL CLIN EXP RES, V19, P441, DOI 10.1111/j.1530-0277.1995.tb01528.x
   Bikman BT, 2011, J CLIN INVEST, V121, P4222, DOI 10.1172/JCI57144
   Borai A, 2011, BMC MED RES METHODOL, V11, DOI 10.1186/1471-2288-11-158
   Bourogaa E, 2013, J PHYSIOL BIOCHEM, V69, P227, DOI 10.1007/s13105-012-0206-7
   Brown MS, 2008, CELL METAB, V7, P95, DOI 10.1016/j.cmet.2007.12.009
   Buechler C, 2009, J GASTROEN HEPATOL, V24, P558, DOI 10.1111/j.1440-1746.2008.05693.x
   Carr RM, 2015, CURR ATHEROSCLER REP, V17, DOI 10.1007/s11883-015-0500-2
   Carr RM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0097118
   Carr RM, 2013, ALCOHOL CLIN EXP RES, V37, P1091, DOI 10.1111/acer.12075
   Chalasani N, 2012, HEPATOLOGY, V55, P2005, DOI 10.1002/hep.25762
   Charlton MR, 2011, GASTROENTEROLOGY, V141, P1249, DOI 10.1053/j.gastro.2011.06.061
   Chen P, 2015, GASTROENTEROLOGY, V148, P203, DOI 10.1053/j.gastro.2014.09.014
   Chen WQ, 2010, HEPATOLOGY, V52, P1134, DOI 10.1002/hep.23812
   Chen XC, 2007, AM J PHYSIOL-ENDOC M, V292, pE621, DOI 10.1152/ajpendo.00387.2006
   Chen YF, 2011, HEPATOLOGY, V54, P562, DOI 10.1002/hep.24423
   Clugston RD, 2011, J LIPID RES, V52, P2021, DOI 10.1194/jlr.M017368
   Correnti JM, 2014, AM J PHYSIOL-GASTR L, V306, pG959, DOI 10.1152/ajpgi.00395.2013
   de la Monte SM, 2008, J GASTROEN HEPATOL, V23, pE477, DOI 10.1111/j.1440-1746.2008.05339.x
   de la Monte SM, 2011, HEPATOL RES, V41, P386, DOI 10.1111/j.1872-034X.2011.00775.x
   Deaciuc IV, 2000, ALCOHOL CLIN EXP RES, V24, P1557, DOI 10.1111/j.1530-0277.2000.tb04575.x
   DeFronzo RA, 2009, DIABETES CARE, V32, pS157, DOI 10.2337/dc09-S302
   DeNucci SM, 2010, GASTROENT RES PRACT, V2010, DOI 10.1155/2010/312790
   Diehl A M, 1997, Liver Transpl Surg, V3, P206, DOI 10.1002/lt.500030303
   DOBROWSKY RT, 1993, J BIOL CHEM, V268, P15523
   Dongiovanni P, 2013, WORLD J GASTROENTERO, V19, P6969, DOI 10.3748/wjg.v19.i41.6969
   Donohue TM, 2006, INT J BIOCHEM CELL B, V38, P92, DOI 10.1016/j.biocel.2005.07.010
   Dunn W, 2005, HEPATOLOGY, V41, P353, DOI 10.1002/hep.20503
   Dupont N, 2014, CURR BIOL, V24, P609, DOI 10.1016/j.cub.2014.02.008
   Enomoto N, 2003, J PHARMACOL EXP THER, V306, P846, DOI 10.1124/jpet.102.047217
   Esfandiari F, 2007, ALCOHOL CLIN EXP RES, V31, P1231, DOI 10.1111/j.1530-0277.2007.00407.x
   FAWCETT J, 1993, AM J PHYSIOL, V264, pE420, DOI 10.1152/ajpendo.1993.264.3.E420
   Feng B, 2013, ANN NY ACAD SCI, V1281, P160, DOI 10.1111/nyas.12009
   Forsyth CB, 2009, ALCOHOL, V43, P163, DOI 10.1016/j.alcohol.2008.12.009
   FRENCH SW, 1986, ALCOHOL CLIN EXP RES, V10, pS13, DOI 10.1111/j.1530-0277.1986.tb05175.x
   Friedrich K, 2014, J GASTROEN HEPATOL, V29, P1477, DOI 10.1111/jgh.12540
   Gao B, 2011, GASTROENTEROLOGY, V141, P1572, DOI 10.1053/j.gastro.2011.09.002
   Garcia-Ruiz C, 2015, J HEPATOL, V62, P219, DOI 10.1016/j.jhep.2014.09.023
   Grösch S, 2012, PROG LIPID RES, V51, P50, DOI 10.1016/j.plipres.2011.11.001
   GRUNNET N, 1985, ALCOHOL, V2, P157, DOI 10.1016/0741-8329(85)90035-7
   Hart CL, 2010, BMJ-BRIT MED J, V340, DOI 10.1136/bmj.c1240
   He JM, 2007, HEPATOLOGY, V46, P1791, DOI 10.1002/hep.21904
   He L, 2006, J BIOL CHEM, V281, P11126, DOI 10.1074/jbc.M510724200
   He L, 2007, MOL ENDOCRINOL, V21, P2541, DOI 10.1210/me.2007-0036
   He SQ, 2010, J BIOL CHEM, V285, P6706, DOI 10.1074/jbc.M109.064501
   Henao-Mejia J, 2012, NATURE, V482, P179, DOI 10.1038/nature10809
   HOEK JB, 1988, BIOCHEM J, V251, P865, DOI 10.1042/bj2510865
   Holland WL, 2013, SCIENCE, V342, P1460, DOI 10.1126/science.1249077
   Holland WL, 2011, NAT MED, V17, P55, DOI 10.1038/nm.2277
   Huang YC, 2010, P NATL ACAD SCI USA, V107, P7892, DOI 10.1073/pnas.1003585107
   ITURRIAGA H, 1988, AM J CLIN NUTR, V47, P235, DOI 10.1093/ajcn/47.2.235
   IVERSEN J, 1984, GASTROENTEROLOGY, V87, P1138
   Kadowaki T, 2005, ENDOCR REV, V26, P439, DOI 10.1210/er.2005-0005
   Kang L, 2007, J BIOL CHEM, V282, P28465, DOI 10.1074/jbc.M705503200
   Kasztelan-Szczerbinska B, 2013, MEDIAT INFLAMM, V2013, DOI [DOI 10.1155/2013/148526, 10.1155/2013/148526]
   Kersten S, 1999, J CLIN INVEST, V103, P1489, DOI 10.1172/JCI6223
   Keshavarzian A, 2001, J PHARMACOL EXP THER, V299, P442
   Kim HJ, 1999, J BIOL CHEM, V274, P25892, DOI 10.1074/jbc.274.36.25892
   Kirpich IA, 2012, ALCOHOL CLIN EXP RES, V36, P835, DOI 10.1111/j.1530-0277.2011.01673.x
   Kong LB, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-246
   Kotronen A, 2008, ARTERIOSCL THROM VAS, V28, P27, DOI 10.1161/ATVBAHA.107.147538
   Kruszynska YT, 1998, J HEPATOL, V28, P280
   Lang CH, 2014, ALCOHOL CLIN EXP RES, V38, P897, DOI 10.1111/acer.12343
   Le Roy T, 2013, GUT, V62, P1787, DOI 10.1136/gutjnl-2012-303816
   LEA MA, 1993, INT J BIOCHEM, V25, P457, DOI 10.1016/0020-711X(93)90651-T
   Lebrun V, 2013, CLIN SCI, V125, P501, DOI 10.1042/CS20130064
   Lee JM, 2010, J BIOL CHEM, V285, P32182, DOI 10.1074/jbc.M110.134890
   Lee JS, 2007, DIABETES RES CLIN PR, V77, pS49, DOI 10.1016/j.diabres.2007.01.033
   Lefebvre P, 2009, PHYSIOL REV, V89, P147, DOI 10.1152/physrev.00010.2008
   LEFEVRE A, 1970, J CLIN INVEST, V49, P1775, DOI 10.1172/JCI106395
   LEO MA, 1983, HEPATOLOGY, V3, P1
   Liangpunsakul S, 2012, AM J PHYSIOL-GASTR L, V302, pG515, DOI 10.1152/ajpgi.00455.2011
   Liangpunsakul S, 2010, AM J PHYSIOL-GASTR L, V298, pG1004, DOI 10.1152/ajpgi.00482.2009
   Lieber CS, 2008, BIOCHEM BIOPH RES CO, V373, P246, DOI 10.1016/j.bbrc.2008.06.006
   LIEBER CS, 1994, METHOD ENZYMOL, V233, P585
   LIEBER CS, 1965, J CLIN INVEST, V44, P1009, DOI 10.1172/JCI105200
   Lindtner C, 2013, SCI TRANSL MED, V5, DOI 10.1126/scitranslmed.3005123
   Liu JY, 2014, WORLD J GASTROENTERO, V20, P14672, DOI 10.3748/wjg.v20.i40.14672
   Lívero FAR, 2014, CHEM-BIOL INTERACT, V217, P19, DOI 10.1016/j.cbi.2014.03.014
   Lizarazo D, 2013, J GASTROEN HEPATOL, V28, P1660, DOI 10.1111/jgh.12291
   Loomba R, 2009, ALIMENT PHARM THER, V30, P1137, DOI 10.1111/j.1365-2036.2009.04141.x
   Lu MJ, 2012, NAT MED, V18, P388, DOI 10.1038/nm.2686
   MAGNUSSON J, 1987, SCAND J GASTROENTERO, V22, P301, DOI 10.3109/00365528709078595
   Marra F, 2009, HEPATOLOGY, V50, P957, DOI 10.1002/hep.23046
   Mathews S, 2014, AM J PHYSIOL-GASTR L, V306, pG819, DOI 10.1152/ajpgi.00041.2014
   Matsuzaka T, 2012, HEPATOLOGY, V56, P2199, DOI 10.1002/hep.25932
   Meng ZJ, 2013, J DIABETES RES, V2013, DOI 10.1155/2013/218102
   MEZEY E, 1980, AM J CLIN NUTR, V33, P2709, DOI 10.1093/ajcn/33.12.2709
   Minato T, 2014, MOL MED, V20, P490, DOI 10.2119/molmed.2014.00048
   Mudaliar S, 2013, GASTROENTEROLOGY, V145, P574, DOI 10.1053/j.gastro.2013.05.042
   Muoio DM, 2008, NAT REV MOL CELL BIO, V9, P193, DOI 10.1038/nrm2327
   Mutlu E, 2009, ALCOHOL CLIN EXP RES, V33, P1836, DOI 10.1111/j.1530-0277.2009.01022.x
   Mutlu EA, 2012, AM J PHYSIOL-GASTR L, V302, pG966, DOI 10.1152/ajpgi.00380.2011
   Nascimento Andre F, 2013, Hepatobiliary Surg Nutr, V2, P252, DOI 10.3978/j.issn.2304-3881.2013.07.05
   National Institute on Alcohol Abuse and Alcoholism (U.S.), 2005, ALCOHOL ALERT, V66
   Naveau S, 1997, HEPATOLOGY, V25, P108, DOI 10.1002/hep.510250120
   Neuschwander-Tetri BA, 2015, LANCET, V385, P956, DOI 10.1016/S0140-6736(14)61933-4
   Nishitani Yoko, 2008, Nihon Arukoru Yakubutsu Igakkai Zasshi, V43, P35
   O'Shea RS, 2010, HEPATOLOGY, V51, P307, DOI 10.1002/hep.23258
   Ohata M, 2004, ALCOHOL CLIN EXP RES, V28, p139S, DOI 10.1097/01.ALC.0000134412.38510.F7
   Okada-Iwabu M, 2013, NATURE, V503, P493, DOI 10.1038/nature12656
   Onishi Y, 2003, BIOCHEM BIOPH RES CO, V303, P788, DOI 10.1016/S0006-291X(03)00407-8
   Palmer ND, 2013, HEPATOLOGY, V58, P966, DOI 10.1002/hep.26440
   Pang MY, 2009, J HEPATOL, V50, P1192, DOI 10.1016/j.jhep.2009.01.021
   Parlesak A, 2000, J HEPATOL, V32, P742, DOI 10.1016/S0168-8278(00)80242-1
   PATEL BC, 1991, AM J PHYSIOL, V261, pG199, DOI 10.1152/ajpgi.1991.261.2.G199
   PELLEYMOUNTER MA, 1995, SCIENCE, V269, P540, DOI 10.1126/science.7624776
   Perry RJ, 2014, NATURE, V510, P84, DOI 10.1038/nature13478
   Peter A, 2014, DIABETOLOGIA, V57, P2103, DOI 10.1007/s00125-014-3310-0
   Piquet MA, 2004, J HEPATOL, V41, P721, DOI 10.1016/j.jhep.2004.07.002
   Powell DJ, 2003, MOL CELL BIOL, V23, P7794, DOI 10.1128/MCB.23.21.7794-7808.2003
   Qiao AJ, 2011, HEPATOLOGY, V54, P509, DOI 10.1002/hep.24402
   Rachakonda V, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0113860
   Rachakonda V, 2014, ALCOHOL CLIN EXP RES, V38, P2712, DOI 10.1111/acer.12558
   Ramirez T, 2013, J GASTROEN HEPATOL, V28, P179, DOI 10.1111/j.1440-1746.2012.07256.x
   Ramirez T, 2013, ALCOHOL ALCOHOLISM, V48, P39, DOI 10.1093/alcalc/ags106
   Raynard B, 2002, HEPATOLOGY, V35, P635, DOI 10.1053/jhep.2002.31782
   Rogers CQ, 2008, IUBMB LIFE, V60, P790, DOI 10.1002/iub.124
   Romeo S, 2008, NAT GENET, V40, P1461, DOI 10.1038/ng.257
   Schattenberg JRM, 2005, J BIOL CHEM, V280, P9887, DOI 10.1074/jbc.M410310200
   Services UDoHaH, 2000, US C ALC HLTH HIGH C, P364
   Shen Z, 2010, AM J PHYSIOL-GASTR L, V298, pG364, DOI 10.1152/ajpgi.00456.2009
   Shklyaev S, 2003, P NATL ACAD SCI USA, V100, P14217, DOI 10.1073/pnas.2333912100
   SHMUELI E, 1993, HEPATOLOGY, V18, P86, DOI 10.1002/hep.1840180115
   Song ZY, 2008, HEPATOLOGY, V47, P867, DOI 10.1002/hep.22074
   Stepanova M, 2012, CLIN GASTROENTEROL H, V10, P646, DOI 10.1016/j.cgh.2011.12.039
   Stepanova M, 2010, GUT, V59, P1410, DOI 10.1136/gut.2010.213553
   Stickel F, 2012, GUT, V61, P150, DOI 10.1136/gutjnl-2011-301239
   Stickel F, 2011, HEPATOLOGY, V53, P86, DOI 10.1002/hep.24017
   Tan XB, 2012, AM J PATHOL, V181, P1279, DOI 10.1016/j.ajpath.2012.06.013
   Thakur V, 2006, AM J PHYSIOL-GASTR L, V290, pG998, DOI 10.1152/ajpgi.00553.2005
   Tian C, 2010, NAT GENET, V42, P21, DOI 10.1038/ng.488
   Tomita K, 2005, ALCOHOL CLIN EXP RES, V29, p240S, DOI 10.1097/01.alc.0000191126.11479.69
   Tomita K, 2004, GASTROENTEROLOGY, V126, P873, DOI 10.1053/j.gastro.2003.12.008
   TSUKAMOTO H, 1986, HEPATOLOGY, V6, P814, DOI 10.1002/hep.1840060503
   TSUKAMOTO H, 1984, AM J PHYSIOL, V247, pR595, DOI 10.1152/ajpregu.1984.247.3.R595
   TSUKAMOTO H, 1995, J CLIN INVEST, V96, P620, DOI 10.1172/JCI118077
   TUMA DJ, 1991, ALCOHOL CLIN EXP RES, V15, P808, DOI 10.1111/j.1530-0277.1991.tb00606.x
   Turban S, 2011, FEBS LETT, V585, P269, DOI 10.1016/j.febslet.2010.12.022
   Ueno A, 2012, NAT PROTOC, V7, P771, DOI 10.1038/nprot.2012.014
   Varela GM, 2008, AM J PHYSIOL-GASTR L, V295, pG621, DOI 10.1152/ajpgi.90204.2008
   Wang Y, 2010, ALCOHOL CLIN EXP RES, V34, P567, DOI 10.1111/j.1530-0277.2009.01122.x
   Wang Y, 2013, ACTA HISTOCHEM, V115, P557, DOI 10.1016/j.acthis.2012.12.005
   WATSON CG, 1987, J CLIN PSYCHOL, V43, P404, DOI 10.1002/1097-4679(198705)43:3<404::AID-JCLP2270430315>3.0.CO;2-4
   Watson ML, 2009, BIOCHEM J, V417, P791, DOI 10.1042/BJ20081149
   Wilson PA, 2006, J LIPID RES, V47, P1940, DOI 10.1194/jlr.M600185-JLR200
   WOLFLA CE, 1988, ARCH BIOCHEM BIOPHYS, V263, P69, DOI 10.1016/0003-9861(88)90614-5
   Wu WB, 2014, BIOCHEM BIOPH RES CO, V443, P68, DOI 10.1016/j.bbrc.2013.11.057
   Xu AM, 2003, J CLIN INVEST, V112, P91, DOI 10.1172/JCI200317797
   Xu J, 1999, J BIOL CHEM, V274, P23577, DOI 10.1074/jbc.274.33.23577
   Xu J, 2011, J HEPATOL, V55, P673, DOI 10.1016/j.jhep.2010.12.034
   Yamauchi T, 2003, NATURE, V423, P762, DOI 10.1038/nature01705
   Yin M, 1999, GASTROENTEROLOGY, V117, P942, DOI 10.1016/S0016-5085(99)70354-9
   You M, 2004, ALCOHOL, V34, P39, DOI 10.1016/j.alcohol.2004.07.004
   You M, 2005, HEPATOLOGY, V42, P568, DOI 10.1002/hep.20821
   You M, 2004, GASTROENTEROLOGY, V127, P1798, DOI 10.1053/j.gastro.2004.09.049
   You M, 2008, J NUTR, V138, P497, DOI 10.1093/jn/138.3.497
   Zein NN, 2000, J HEPATOL, V32, P209, DOI 10.1016/S0168-8278(00)80065-3
   Zhang XD, 2014, HEPATOLOGY, V60, P2008, DOI 10.1002/hep.27199
   Zhao LN, 2009, BRIT J NUTR, V101, P1467, DOI 10.1017/S0007114508094646
   Zhao ZW, 2011, ALCOHOL CLIN EXP RES, V35, P229, DOI 10.1111/j.1530-0277.2010.01338.x
   Zhu ZT, 2014, ALCOHOL CLIN EXP RES, V38, P1510, DOI 10.1111/acer.12418
   Zivkovic AM, 2007, AM J CLIN NUTR, V86, P285, DOI 10.1093/ajcn/86.2.285
   Zong HH, 2012, AM J PHYSIOL-ENDOC M, V302, pE532, DOI 10.1152/ajpendo.00258.2011
NR 175
TC 45
Z9 48
U1 0
U2 6
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2015
VL 1353
BP 1
EP 20
DI 10.1111/nyas.12787
PG 20
WC Endocrinology & Metabolism
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA BD9TS
UT WOS:000365305100001
PM 25998863
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Uetake, Y
   Ikeda, H
   Irie, R
   Tejima, K
   Matsui, H
   Ogura, S
   Wang, H
   Mu, SY
   Hirohama, D
   Ando, K
   Sawamura, T
   Yatomi, Y
   Fujita, T
   Shimosawa, T
AF Uetake, Yuzaburo
   Ikeda, Hitoshi
   Irie, Rie
   Tejima, Kazuaki
   Matsui, Hiromitsu
   Ogura, Sayoko
   Wang, Hong
   Mu, ShengYu
   Hirohama, Daigoro
   Ando, Katsuyuki
   Sawamura, Tatsuya
   Yatomi, Yutaka
   Fujita, Toshiro
   Shimosawa, Tatsuo
TI High-salt in addition to high-fat diet may enhance inflammation and
   fibrosis in liver steatosis induced by oxidative stress and dyslipidemia
   in mice
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE High salt diet induced oxidative stress; Oxidative stress; NADPH
   oxidase; Anti-oxidant tempol; Nonalcoholic fatty liver disease
ID LOW-DENSITY-LIPOPROTEIN; NONALCOHOLIC STEATOHEPATITIS; SENSITIVE
   HYPERTENSION; INSULIN-RESISTANCE; HEPATIC STEATOSIS; FOLLOW-UP;
   VITAMIN-E; DISEASE; INJURY; OBESITY
AB Background: It is widely known that salt is an accelerating factor for the progression of metabolic syndrome and causes cardiovascular diseases, most likely due to its pro-oxidant properties. We hypothesized that excessive salt intake also facilitates the development of nonalcoholic steatohepatitis (NASH), which is frequently associated with metabolic syndrome.
   Methods: We examined the exacerbating effect of high-salt diet on high-fat diet-induced liver injury in a susceptible model to oxidative stress, apoE knockout and lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) transgenic mice.
   Results: High-salt diet led to NASH in high-fat diet-fed LOX-1 transgenic/apoE knockout mice without affecting high-fat diet-induced dyslipidemia or hepatic triglyceride accumulation. Additionally, a high-salt and high-fat diet stimulated oxidative stress production and inflammatory reaction to a greater extent than did a high-fat diet in the liver of LOX-1 transgenic/apoE knockout mice.
   Conclusions: We demonstrated that high-salt diet exacerbated NASH in high-fat diet-fed LOX-1 transgenic /apoE knockout mice and that this effect was associated with the stimulation of oxidative and inflammatory processes; this is the first study to suggest the important role of excessive salt intake in the development of NASH.
C1 [Uetake, Yuzaburo; Ogura, Sayoko; Wang, Hong; Hirohama, Daigoro; Ando, Katsuyuki; Fujita, Toshiro; Shimosawa, Tatsuo] Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Tokyo, Japan.
   [Uetake, Yuzaburo] Univ Tokyo, Grad Sch Med, Off Res Eth Support, Tokyo, Japan.
   [Ikeda, Hitoshi; Yatomi, Yutaka; Shimosawa, Tatsuo] Tokyo Univ Hosp, Clin Lab, Tokyo 113, Japan.
   [Ikeda, Hitoshi] Univ Tokyo, Grad Sch Med, Dept Gastroenterol, Tokyo, Japan.
   [Irie, Rie] Kawasaki Municipal Hosp, Dept Pathol, Kawasaki, Kanagawa, Japan.
   [Tejima, Kazuaki] Toshiba Gen Hosp, Dept Gastroenterol, Tokyo, Japan.
   [Matsui, Hiromitsu; Ogura, Sayoko] Nihon Univ, Sch Med, Fac Med, Div Lab Med,Dept Pathol & Microbiol, Tokyo, Japan.
   [Mu, ShengYu; Fujita, Toshiro] Univ Tokyo, Div Clin Epigenet, Res Ctr Adv Sci & Technol, Tokyo, Japan.
   [Sawamura, Tatsuya] Natl Cerebral & Cardiovasc Ctr Res Inst, Dept Vasc Physiol, Osaka, Japan.
   [Sawamura, Tatsuya] Shinshu Univ, Sch Med, Dept Physiol, Nagano, Japan.
C3 University of Tokyo; University of Tokyo; University of Tokyo;
   University of Tokyo; Toshiba Corporation; Nihon University; University
   of Tokyo; National Cerebral & Cardiovascular Center - Japan; Shinshu
   University
RP Shimosawa, T (corresponding author), Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Tokyo, Japan.
EM tshimo-tky@umin.ac.jp
RI Sawamura, Tatsuya/E-7103-2010
OI Hirohama, Daigoro/0000-0002-1885-1263; Yatomi,
   Yutaka/0000-0003-1719-4297
FU Grants-in-Aid for Scientific Research [26461262] Funding Source: KAKEN
CR Adams LA, 2005, GASTROENTEROLOGY, V129, P113, DOI 10.1053/j.gastro.2005.04.014
   Arima S, 2014, INT J MOL MED, V33, P68, DOI 10.3892/ijmm.2013.1544
   BACON BR, 1994, GASTROENTEROLOGY, V107, P1103, DOI 10.1016/0016-5085(94)90235-6
   BRAILLON A, 1985, GUT, V26, P133, DOI 10.1136/gut.26.2.133
   Browning JD, 2004, HEPATOLOGY, V40, P1387, DOI 10.1002/hep.20466
   Browning JD, 2004, J CLIN INVEST, V114, P147, DOI 10.1172/JCI200422422
   Brunt EM, 1999, AM J GASTROENTEROL, V94, P2467, DOI 10.1111/j.1572-0241.1999.01377.x
   Eichhorn B, 2009, CARDIOVASC RES, V82, P493, DOI 10.1093/cvr/cvp089
   Ekstedt M, 2006, HEPATOLOGY, V44, P865, DOI 10.1002/hep.21327
   Fujita M, 2007, HYPERTENSION, V50, P360, DOI 10.1161/HYPERTENSIONAHA.107.091009
   Gregg D, 2003, AM J PHYSIOL-CELL PH, V285, pC723, DOI 10.1152/ajpcell.00230.2003
   HARATS D, 1995, J CLIN INVEST, V95, P1335, DOI 10.1172/JCI117784
   Harrison SA, 2003, AM J GASTROENTEROL, V98, P2485, DOI 10.1111/j.1572-0241.2003.08699.x
   Rosón MI, 2011, J NEPHROL, V24, P119, DOI 10.5301/JN.2010.5824
   Inoue K, 2005, CIRC RES, V97, P176, DOI 10.1161/01.RES.0000174286.73200.d4
   Jones OM, 2005, BRIT J SURG, V92, P1165, DOI 10.1002/bjs.4888
   Kido M, 2008, HYPERTENSION, V51, P225, DOI 10.1161/HYPERTENSIONAHA.107.098251
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Kugelmas M, 2003, HEPATOLOGY, V38, P413, DOI 10.1053/jhep.2003.50316
   Lenda DM, 2002, AM J PHYSIOL-HEART C, V282, pH395, DOI 10.1152/ajpheart.0354.2001
   Li WG, 2001, J BIOL CHEM, V276, P29251, DOI 10.1074/jbc.M102124200
   Marchesini G, 2001, DIABETES, V50, P1844, DOI 10.2337/diabetes.50.8.1844
   Matsui H, 2006, HYPERTENSION, V48, P225, DOI 10.1161/01.HYP.0000232617.48372.cb
   Mehta JL, 2007, CIRC RES, V100, P1634, DOI 10.1161/CIRCRESAHA.107.149724
   Mu S, 2011, NAT MED, V17, P573, DOI 10.1038/nm.2337
   Musso G, 2003, HEPATOLOGY, V37, P909, DOI 10.1053/jhep.2003.50132
   NASRALLAH SM, 1981, DIGEST DIS SCI, V26, P325, DOI 10.1007/BF01308373
   PIEDRAHITA JA, 1992, P NATL ACAD SCI USA, V89, P4471, DOI 10.1073/pnas.89.10.4471
   Ratziu V, 2005, GASTROENTEROLOGY, V128, P1898, DOI 10.1053/j.gastro.2005.03.084
   Sawamura T, 1997, NATURE, V386, P73, DOI 10.1038/386073a0
   Söderberg C, 2010, HEPATOLOGY, V51, P595, DOI 10.1002/hep.23314
   Tejima K, 2004, GASTROENTEROLOGY, V127, P1488, DOI 10.1053/j.gastro.2004.07.023
   Tian N, 2008, AM J PHYSIOL-REG I, V295, pR1858, DOI [10.1152/ajpregu.90650.2008, 10.1152/ajpheart.00981.2007]
   Ushio-Fukai M, 2001, ARTERIOSCL THROM VAS, V21, P489, DOI 10.1161/01.ATV.21.4.489
   WANLESS IR, 1990, HEPATOLOGY, V12, P1106, DOI 10.1002/hep.1840120505
   Willner IR, 2001, AM J GASTROENTEROL, V96, P2957
NR 36
TC 43
Z9 45
U1 3
U2 26
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD FEB 13
PY 2015
VL 14
AR 6
DI 10.1186/s12944-015-0002-9
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA CC0ZI
UT WOS:000350068200001
PM 25888871
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Thomas, J
   Patel, A
   Das Sivadasan, S
   Sreevallabhan, S
   Madhavamenon, KI
   Mohanan, R
AF Thomas, Jestin
   Patel, Anand
   Das Sivadasan, Syam
   Sreevallabhan, Sheethal
   Madhavamenon, Krishnakumar Illathu
   Mohanan, Ratheesh
TI Clove bud (Syzygium aromaticum L.) polyphenol helps to mitigate
   metabolic syndrome by establishing intracellular redox homeostasis and
   glucose metabolism: A randomized, double-blinded, active-controlled
   comparative study
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Clove buds; Clovinol; Glutathione; Metabolic syndrome; Polyphenol; Redox
   homeostasis
ID OXIDATIVE STRESS; ORAL GLUTATHIONE; RICH EXTRACT; SUPPLEMENTATION;
   INFLAMMATION; MECHANISMS; IMMUNITY; THIOLS
AB Present randomised double-blinded comparative study investigated the influence of clove buds (Syzygium aromaticum) polyphenol extract (Clovinol) in comparison with synthetic glutathione (s-GSH) (250 mg/day for 84 days) on healthy adults (N = 70) characterised with metabolic syndrome (MetS). Outcome measures included plasma concentration of endogenous antioxidants, inflammatory markers, blood sugar and lipid metabolism markers, in addition to haematological and biochemical parameters of safety. Clovinol enhanced the plasma concentration of GSH by 6-fold and offered statistically significant enhancement in Nrf2, antioxidant enzymes and in GSH/GSSG ratio. Treatment with Clovinol also improved FBS, PPG, HbA1c, HOMA-IR and insulin levels indicating modulation of insulin resistance. Moreover, Clovinol caused significant reduction in total cholesterol, triglycerides, LDL and increased HDL, while s-GSH showed no significant effect on blood glucose and lipid metabolism. Clovinol did not show any significant side effects or toxic deviations in haematological and biochemical parameters, but significantly increased the total leukocyte and reduced neutrophil/lymphocyte ratio and inflammatory markers (IL-1 beta and TNF-alpha).
C1 [Thomas, Jestin] Leads Clin Res & Bio Serv Pvt Ltd, Bangalore 560043, India.
   [Patel, Anand] Anand Multi Special Hosp, Dept Gen Med, B Tower Sundervan Complex, Vadodara 390016, Gujarat, India.
   [Das Sivadasan, Syam; Madhavamenon, Krishnakumar Illathu] Akay Nat Ingredients, R&D Ctr, Cochin 683561, Kerala, India.
   [Sreevallabhan, Sheethal; Mohanan, Ratheesh] St Thomas Coll, Dept Biochem, Kottayam 686574, Kerala, India.
RP Mohanan, R (corresponding author), St Thomas Coll, Dept Biochem, Kottayam 686574, Kerala, India.
EM biochemistrystcp@gmail.com
CR Aboubakr EM, 2022, NANOTECHNOL REV, V11, P117, DOI 10.1515/ntrev-2022-0010
   Allen J, 2011, J ALTERN COMPLEM MED, V17, P827, DOI 10.1089/acm.2010.0716
   [Anonymous], 2018, CLIN INTERV AGING, DOI DOI 10.2147/CIA.S158513
   Aquilano K, 2014, FRONT PHARMACOL, V5, DOI 10.3389/fphar.2014.00196
   Baba Shahid P., 2018, Current Opinion in Toxicology, V7, P133, DOI 10.1016/j.cotox.2018.03.005
   Batiha GES, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10020202
   Battino M, 2018, BIOTECHNOL ADV, V36, P358, DOI 10.1016/j.biotechadv.2017.12.012
   BLOOM JC, 1993, TOXICOL PATHOL, V21, P130, DOI 10.1177/019262339302100203
   Bukhari SNA, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11030554
   Cadet J, 2012, CANCER LETT, V327, P5, DOI 10.1016/j.canlet.2012.04.005
   Cazzola M, 2021, LUNG, V199, P335, DOI 10.1007/s00408-021-00465-3
   Chen XF, 2018, NUTR DIABETES, V8, DOI 10.1038/s41387-017-0009-6
   Dabou S., 2018, Journal of Metabolic Syndrome, V7, P236, DOI [DOI 10.4172/2167-0943.1000236, 10.4172/2167-0943, DOI 10.4172/2167-0943]
   El-Hafidi M, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/2101562
   Espinosa-Diez C, 2015, REDOX BIOL, V6, P183, DOI 10.1016/j.redox.2015.07.008
   Faqi AS, 2013, COMPREHENSIVE GUIDE TO TOXICOLOGY IN PRECLINICAL DRUG DEVELOPMENT, P1
   Fraternale A, 2017, BIOL CHEM, V398, P261, DOI 10.1515/hsz-2016-0202
   Ghezzi P, 2011, INT J GEN MED, V4, P105, DOI 10.2147/IJGM.S15618
   Halliwell B, 1999, FREE RADICAL RES, V31, P261, DOI 10.1080/10715769900300841
   Honda Y, 2017, BMC GASTROENTEROL, V17, DOI 10.1186/s12876-017-0652-3
   Issac A, 2015, FOOD FUNCT, V6, P842, DOI [10.1039/c4fo00711e, 10.1039/C4FO00711E]
   Johannah NM, 2015, FOOD FUNCT, V6, P3373, DOI [10.1039/c5fo00682a, 10.1039/C5FO00682A]
   Jose S. P., 2018, Journal of Food Research, V7, P10, DOI 10.5539/jfr.v7n1p10
   Kalamkar S, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11051026
   Lee JS, 2020, J MED INTERNET RES, V22, DOI 10.2196/17031
   Letchuman S, 2019, MINTAGE J PHARM MEDI, V8, P21
   Luis Carla, 2020, Porto Biomed J, V5, pe108, DOI 10.1097/j.pbj.0000000000000108
   Lutchmansingh FK, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0198626
   Mammen RR, 2018, J MED FOOD, V21, P1188, DOI 10.1089/jmf.2017.4177
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Miranda AM, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0165791
   Mohammadi M, 2017, REP BIOCHEM MOL BIOL, V6, P74
   Mohan R, 2019, BMC COMPLEM ALTERN M, V19, DOI 10.1186/s12906-019-2507-7
   MOSS GA, 1975, CLIN CHEM, V21, P1422
   Nakatake R, 2018, FUNCT FOODS HEALTH D, V8, P544, DOI 10.31989/ffhd.v8i11.547
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Petersen MC, 2018, PHYSIOL REV, V98, P2133, DOI 10.1152/physrev.00063.2017
   Picklo MJ, 2015, NUTR REV, V73, P858, DOI 10.1093/nutrit/nuv042
   Rahman I, 2006, NAT PROTOC, V1, P3159, DOI 10.1038/nprot.2006.378
   Richie JP, 2015, EUR J NUTR, V54, P251, DOI 10.1007/s00394-014-0706-z
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Sirtori CR, 2017, ANN MED, V49, P678, DOI 10.1080/07853890.2017.1366042
   Sondergard S. D., 2021, APPL PHYSIOL NUTR ME, DOI [10.1139/apnm, DOI 10.1139/APNM]
   Squadrito F, 2013, J CLIN ENDOCR METAB, V98, P3366, DOI 10.1210/jc.2013-1180
   Zhang ZG, 2015, REV ENDOCR METAB DIS, V16, P35, DOI 10.1007/s11154-014-9305-9
   Zitka O, 2012, ONCOL LETT, V4, P1247, DOI 10.3892/ol.2012.931
NR 46
TC 5
Z9 5
U1 0
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD NOV
PY 2022
VL 98
AR 105273
DI 10.1016/j.jff.2022.105273
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 5Q9BW
UT WOS:000874119100003
OA gold
DA 2025-06-11
ER

PT J
AU Shakib, Z
   Shahraki, N
   Razavi, BM
   Hosseinzadeh, H
AF Shakib, Zahra
   Shahraki, Naghmeh
   Razavi, Bibi Marjan
   Hosseinzadeh, Hossein
TI Aloe vera as an herbal medicine in the treatment of metabolic
   syndrome: A review
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE Aloe barbadensis; Aloe vera; diabetes mellitus; dyslipidemia;
   hypertension; metabolic syndrome; obesity
ID LEAF GEL; DIABETES-MELLITUS; FAT MASS; BARBADENSIS; EMODIN; L.; EXTRACT;
   OBESITY; PLANTS; CONSTITUENTS
AB Metabolic syndrome (MS) is a highly prevalent health problem worldwide and is associated with different risk factors, including hyperglycemia, dyslipidemia, hypertension, and obesity. This condition increases the risk of developing type II diabetes mellitus and cardiovascular problems. The MS is one of the most important health concerns in industrialized countries and mainly results from a sedentary lifestyle, high levels of subjective stress, and unhealthy diets. Nowadays, the identification of appropriate health care approaches, such as herbal medicines, with fewer side effects is more favorable, especially with regard to the adverse effects of chemical drugs. Aloe barbadensis Miller known as Aloe vera is a useful plant with two major parts, including leaves that contain high concentrations of anthraquinone compounds and a clear gel. The gel is used as a food with several beneficial properties, such as antiinflammatory, antioxidant, antiviral, antibacterial, and wound-healing features. Other effects of A. vera, such as its lipid-lowering, antihypertensive, antidiabetic, antiobesity, and cardioprotective impacts, have been demonstrated in several studies. The present study was conducted to review the evidence on the pharmacological effects of A. vera on the different components of MS.
C1 [Shakib, Zahra; Shahraki, Naghmeh] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran.
   [Razavi, Bibi Marjan] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Targeted Drug Delivery Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Razavi, Bibi Marjan; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran.
EM hosseinzadehh@mums.ac.ir
RI razavi, Bibi Marjan/AAY-5636-2020; Hosseinzadeh, Hossein/F-3013-2010
OI razavi, Bibi Marjan/0000-0002-7450-9286; Hosseinzadeh,
   Hossein/0000-0002-3483-851X
CR Ahmad S, 2013, LIPIDS HEALTH DIS, V12, DOI 10.1186/1476-511X-12-86
   Akaberi M, 2016, PHYTOTHER RES, V30, P540, DOI 10.1002/ptr.5570
   Al-Goblan AS, 2014, DIABETES METAB SYNDR, V7, P587, DOI 10.2147/DMSO.S67400
   Alinejad-Mofrad S, 2015, J DIABETES METAB DIS, V14, DOI 10.1186/s40200-015-0137-2
   Alves DS, 2004, BIOCHEM PHARMACOL, V68, P549, DOI 10.1016/j.bcp.2004.04.012
   [Anonymous], J DIETARY S
   Boudreau MD, 2006, J ENVIRON SCI HEAL C, V24, P103, DOI 10.1080/10590500600614303
   Chandan BK, 2007, J ETHNOPHARMACOL, V111, P560, DOI 10.1016/j.jep.2007.01.008
   Chinchilla N, 2013, PHYTOCHEM REV, V12, P581, DOI 10.1007/s11101-013-9323-3
   Choi HC, 2013, NUTRITION, V29, P1110, DOI 10.1016/j.nut.2013.02.015
   Choi S., 2003, Seminars in integrative medicine, DOI [10.1016/S1543-1150(03)00005-X, DOI 10.1016/S1543-1150(03)00005-X]
   Choudhary M, 2014, J FOOD SCI TECH MYS, V51, P90, DOI 10.1007/s13197-011-0459-0
   Cramer H, 2016, EUR J PREV CARDIOL, V23, P1982, DOI 10.1177/2047487316665729
   Delarue J, 2007, CURR OPIN CLIN NUTR, V10, P142, DOI 10.1097/MCO.0b013e328042ba90
   Devaraj S, 2013, METAB SYNDR RELAT D, V11, P35, DOI 10.1089/met.2012.0066
   El-Shemy HA, 2010, CURR MED CHEM, V17, P129, DOI 10.2174/092986710790112620
   Ferro VA, 2003, ANTIMICROB AGENTS CH, V47, P1137, DOI 10.1128/AAC.47.3.1137-1139.2003
   Gamboa-Gómez CI, 2015, EXCLI J, V14, P809, DOI 10.17179/excli2015-186
   Hassani FV, 2016, N-S ARCH PHARMACOL, V389, P931, DOI 10.1007/s00210-016-1256-0
   Heo SK, 2008, J CELL BIOCHEM, V105, P70, DOI 10.1002/jcb.21805
   Hosseini A, 2015, J ENDOCRINOL INVEST, V38, P1147, DOI 10.1007/s40618-015-0313-8
   Hosseinzadeh H, 2014, J ENDOCRINOL INVEST, V37, P783, DOI 10.1007/s40618-014-0096-3
   Huang THW, 2005, BASIC CLIN PHARMACOL, V96, P3, DOI 10.1111/j.1742-7843.2005.pto960102.x
   Huseini HF, 2012, PLANTA MED, V78, P311, DOI 10.1055/s-0031-1280474
   Ji HY, 2018, J PHARMACEUT BIOMED, V156, P104, DOI 10.1016/j.jpba.2018.04.015
   Kar SK, 2018, INT J PHARM SCI RES, V9, P1416, DOI 10.13040/IJPSR.0975-8232.9(4).1416-23
   Kaur Narabjit, 2017, JBI Database System Rev Implement Rep, V15, P2300, DOI 10.11124/JBISRIR-2016-002958
   Kim K, 2018, BIOCHEM BIOPH RES CO, V500, P797, DOI 10.1016/j.bbrc.2018.04.162
   Kim K, 2009, PHYTOMEDICINE, V16, P856, DOI 10.1016/j.phymed.2009.02.014
   Kumar M, 2013, NUTRITION, V29, P574, DOI 10.1016/j.nut.2012.09.006
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Laybutt DR, 2007, DIABETOLOGIA, V50, P752, DOI 10.1007/s00125-006-0590-z
   Lim KM, 2014, BRIT J PHARMACOL, V171, P4300, DOI 10.1111/bph.12804
   Misawa E, 2012, J NUTR SCI VITAMINOL, V58, P195, DOI 10.3177/jnsv.58.195
   Misawa E, 2012, J AGR FOOD CHEM, V60, P2799, DOI 10.1021/jf204465j
   Misawa E, 2008, OBES RES CLIN PRACT, V2, P239, DOI 10.1016/j.orcp.2008.06.002
   Mollazadeh H, 2016, IRAN J BASIC MED SCI, V19, P1258, DOI 10.22038/ijbms.2016.7906
   Motamedi MAK, 2019, OBES SURG, V29, P511, DOI 10.1007/s11695-018-3537-9
   Musunuru K, 2010, LIPIDS, V45, P907, DOI 10.1007/s11745-010-3408-1
   Nguyen DM, 2010, GASTROENTEROL CLIN N, V39, P1, DOI 10.1016/j.gtc.2009.12.014
   Nomaguchi K, 2011, OBES RES CLIN PRACT, V5, pE190, DOI 10.1016/j.orcp.2011.01.002
   Okyar A, 2001, PHYTOTHER RES, V15, P157, DOI 10.1002/ptr.719
   Parihar MS, 2004, J CLIN NEUROSCI, V11, P397, DOI 10.1016/j.jocn.2003.09.008
   Petersen M, 2008, DIABETES CARE, V31, P596, DOI 10.2337/dc08-9017
   Poorfarid M., 2013, J JAHROM U MED SCI, V10, P6
   Pothuraju R, 2016, BENEF MICROBES, V7, P375, DOI 10.3920/BM2015.0083
   Pothuraju R, 2016, PHYTOTHER RES, V30, P200, DOI 10.1002/ptr.5532
   Pugh N, 2001, J AGR FOOD CHEM, V49, P1030, DOI 10.1021/jf001036d
   Radha Maharjan H, 2015, J Tradit Complement Med, V5, P21, DOI 10.1016/j.jtcme.2014.10.006
   Rajasekaran S, 2006, CLIN EXP PHARMACOL P, V33, P232, DOI 10.1111/j.1440-1681.2006.04351.x
   Rajasekaran S, 2004, J MED FOOD, V7, P61, DOI 10.1089/109662004322984725
   Rashidi Ali Akbar, 2013, Pak J Biol Sci, V16, P401, DOI 10.3923/pjbs.2013.401.411
   Razavi BM, 2014, J ENDOCRINOL INVEST, V37, P1031, DOI 10.1007/s40618-014-0150-1
   Razavi BM, 2017, BIOMED PHARMACOTHER, V92, P726, DOI 10.1016/j.biopha.2017.05.113
   Razavi BM, 2017, J SCI FOOD AGR, V97, P1679, DOI 10.1002/jsfa.8134
   Reynolds T, 1999, J ETHNOPHARMACOL, V68, P3, DOI 10.1016/S0378-8741(99)00085-9
   Saito M, 2012, BIOSCI BIOTECH BIOCH, V76, P2049, DOI 10.1271/bbb.120393
   Saleem R, 2001, PLANTA MED, V67, P757, DOI 10.1055/s-2001-18348
   Sanati S, 2018, IRAN J BASIC MED SCI, V21, P439, DOI 10.22038/IJBMS.2018.25200.6238
   Saniasiaya Jeyasakthy, 2017, Oman Med J, V32, P41, DOI 10.5001/omj.2017.08
   Shandiz HT, 2017, PHYTOTHER RES, V31, P1173, DOI 10.1002/ptr.5862
   Sharma P., 2014, Int J Pharm Sci Rev Res, V29, P31
   Shin Eunju, 2011, Immune Netw, V11, P107, DOI 10.4110/in.2011.11.2.107
   Sultana S, 2017, PAK J PHARM SCI, V30, P2311
   Suvitayavat W, 2004, J ETHNOPHARMACOL, V90, P239, DOI 10.1016/j.jep.2003.09.044
   Tabeshpour J, 2017, IRAN J BASIC MED SCI, V20, P557, DOI 10.22038/IJBMS.2017.8682
   Tabeshpour J, 2017, PHYTOTHER RES, V31, P819, DOI 10.1002/ptr.5805
   Tajmohammadi A, 2018, PHYTOTHER RES, V32, P1933, DOI 10.1002/ptr.6153
   Vangkilde J., 2013, Politiken
   Verma P, 2016, INT J PHARMACOGN, V3, P196
   Vogler BK, 1999, BRIT J GEN PRACT, V49, P823
   Wild S, 2004, DIABETES CARE, V27, P1047, DOI 10.2337/diacare.27.5.1047
   Yagi Akira, 2009, Saudi Pharm J, V17, P209, DOI 10.1016/j.jsps.2009.08.007
   Yongchaiyudha S, 1996, PHYTOMEDICINE, V3, P241, DOI 10.1016/S0944-7113(96)80060-2
NR 74
TC 64
Z9 65
U1 0
U2 40
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD OCT
PY 2019
VL 33
IS 10
BP 2649
EP 2660
DI 10.1002/ptr.6465
EA AUG 2019
PG 12
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA JD9FA
UT WOS:000484098300001
PM 31456283
DA 2025-06-11
ER

PT J
AU Armani, A
   Berry, A
   Cirulli, F
   Caprio, M
AF Armani, Andrea
   Berry, Alessandra
   Cirulli, Francesca
   Caprio, Massimiliano
TI Molecular mechanisms underlying metabolic syndrome: the expanding role
   of the adipocyte
SO FASEB JOURNAL
LA English
DT Review
DE adipose tissue; browning; aging; caloric restriction; obesity
ID BROWN ADIPOSE-TISSUE; HIGH-FAT-DIET; ACTIVATED PROTEIN-KINASE;
   WHOLE-BODY GLUCOSE; INSULIN-RESISTANCE; MINERALOCORTICOID RECEPTOR;
   LIFE-SPAN; CALORIE RESTRICTION; OXIDATIVE STRESS; VISCERAL FAT
AB The metabolic syndrome (MetS) is defined as a cluster of 3 or more metabolic and cardiovascular risk factors and represents a serious problem for public health. Altered function of adipose tissue has a significant impact on whole-body metabolism and represents a key driver for the development of these metabolic derangements, collectively referred as to MetS. In particular, increased visceral and ectopic fat deposition play a major role in the development of insulin resistance and MetS. A large body of evidence demonstrates that aging and MetS share several metabolic alterations. Of importance, molecular pathways that regulate lifespan affect key processes of adipose tissue physiology, and transgenic mouse models with adipose-specific alterations in these pathways show derangements of adipose tissue and other metabolic features of MetS, which highlights a causal link between dysfunctional adipose tissue and deleterious effects on whole-body homeostasis. This review analyzes adipose tissue-specific dysfunctions, including metabolic alterations that are related to aging, that have a significant impact on the development of MetS.-Armani, A., Berry, A., Cirulli, F., Caprio, M. Molecular mechanisms underlying metabolic syndrome: the expanding role of the adipocyte.
C1 [Armani, Andrea; Caprio, Massimiliano] Ist Ricovero & Cura Carattere Sci San Raffaele Pi, Lab Cardiovasc Endocrinol, Via Val Cannuta 247, I-00166 Rome, Italy.
   [Berry, Alessandra; Cirulli, Francesca] Ist Super Sanita, Ctr Behav Sci & Mental Hlth, Rome, Italy.
   [Caprio, Massimiliano] San Raffaele Roma Open Univ, Dept Human Sci & Promot Qual Life, Rome, Italy.
C3 Istituto Superiore di Sanita (ISS)
RP Caprio, M (corresponding author), Ist Ricovero & Cura Carattere Sci San Raffaele Pi, Lab Cardiovasc Endocrinol, Via Val Cannuta 247, I-00166 Rome, Italy.
EM massimiliano.caprio@sanraffaele.it
RI Cirulli, Francesca/H-5992-2019; Berry, Alessandra/N-9280-2017; Armani,
   Andrea/AAC-2071-2022; Caprio, Massimiliano/J-3020-2012
OI ARMANI, Andrea/0000-0002-2130-1596; CIRULLI,
   Francesca/0000-0001-9440-1873; Caprio, Massimiliano/0000-0003-0722-7163;
   Berry, Alessandra/0000-0001-6562-9043
FU Ministero della Salute (Progetti Collaborazione Ricercatori Italiani
   all'Estero) [PE-2011-02347070]; Ministero della Salute (Project H2020
   AwE) [633589]
FX This work was supported by the Ministero della Salute (Bando
   2011-2012,Progetti Collaborazione Ricercatori Italiani all'Estero;
   Project Grant PE-2011-02347070 to M.C., and Project H2020 AwE, Grant
   Agreement 633589 to F.C.). The authors acknowledge networking support by
   the European Cooperation in Science and Technology (COST) Action
   Aldosterone and Mineralocorticoid Receptor (ADMIRE) BM1301. The authors
   thank Uberto Pagotto (Alma Mater University of Bologna, Bologna, Italy)
   and Elisa Fabbrini (The Janssen Pharmaceutical Companies of Johnson &
   Johnson) for critical review of the manuscript, and Morag J. Young
   (Centre for Endocrinology and Metabolism, Hudson Institute of Medical
   Research, Clayton, VIC, Australia) for English editing. The authors
   declare no conflicts of interest.
CR Adamiak Paulina, 2016, Pol Merkur Lekarski, V40, P122
   Aguirre GA, 2016, J TRANSL MED, V14, DOI 10.1186/s12967-015-0762-z
   Al-Regaiey KA, 2016, EUR REV MED PHARMACO, V20, P2468
   An KO, 2016, J AM MED DIR ASSOC, V17, DOI 10.1016/j.jamda.2016.07.005
   Armani A, 2015, J MOL ENDOCRINOL, V55, pR1, DOI 10.1530/JME-15-0122
   Armani A, 2014, FASEB J, V28, P3745, DOI 10.1096/fj.13-245415
   Armani A, 2011, TRENDS ENDOCRIN MET, V22, P404, DOI 10.1016/j.tem.2011.05.004
   Baerga R, 2009, AUTOPHAGY, V5, P1118, DOI 10.4161/auto.5.8.9991
   Bain J, 2010, MATURITAS, V66, P16, DOI 10.1016/j.maturitas.2010.01.009
   Ballestri S, 2015, EXPERT REV GASTROENT, V9, P603, DOI 10.1586/17474124.2015.1007955
   Barbato DL, 2016, AGEING RES REV, V28, P85, DOI 10.1016/j.arr.2016.05.007
   Barbato DL, 2015, AGING-US, V7, P869, DOI 10.18632/aging.100832
   Barzilai N, 2012, DIABETES, V61, P1315, DOI 10.2337/db11-1300
   Berbee JFP, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms7356
   Bergeron R, 2001, DIABETES, V50, P1076, DOI 10.2337/diabetes.50.5.1076
   Berniakovich I, 2008, J BIOL CHEM, V283, P34283, DOI 10.1074/jbc.M804362200
   Berry A, 2013, NEUROSCI BIOBEHAV R, V37, P790, DOI 10.1016/j.neubiorev.2013.03.005
   Bhasin S, 2006, NAT CLIN PRACT ENDOC, V2, P146, DOI 10.1038/ncpendmet0120
   Blüher M, 2003, SCIENCE, V299, P572, DOI 10.1126/science.1078223
   Boden G, 1997, DIABETES, V46, P3, DOI 10.2337/diabetes.46.1.3
   Bonomini F, 2015, AGING DIS, V6, P109, DOI 10.14336/AD.2014.0305
   Boström P, 2012, NATURE, V481, P463, DOI 10.1038/nature10777
   Britton KA, 2011, CIRCULATION, V124, pE837, DOI 10.1161/CIRCULATIONAHA.111.077602
   Butera PC, 2010, PHYSIOL BEHAV, V99, P175, DOI 10.1016/j.physbeh.2009.06.010
   Byrne CD, 2013, P NUTR SOC, V72, P412, DOI 10.1017/S0029665113001249
   Cantó C, 2012, PHARMACOL REV, V64, P166, DOI 10.1124/pr.110.003905
   Caprio M, 1999, ENDOCRINOLOGY, V140, P4939, DOI 10.1210/en.140.11.4939
   Caprio M, 2011, ENDOCRINOLOGY, V152, P113, DOI 10.1210/en.2010-0674
   Cava E, 2013, AGING-US, V5, P507, DOI 10.18632/aging.100581
   Chakrabarti P, 2011, J LIPID RES, V52, P1693, DOI 10.1194/jlr.M014647
   Chalkiadaki A, 2012, CELL METAB, V16, P180, DOI 10.1016/j.cmet.2012.07.003
   Chang GR, 2009, BASIC CLIN PHARMACOL, V105, P188, DOI 10.1111/j.1742-7843.2009.00427.x
   Chang GR, 2009, J PHARMACOL SCI, V109, P496, DOI 10.1254/jphs.08215FP
   Chau MDL, 2010, P NATL ACAD SCI USA, V107, P12553, DOI 10.1073/pnas.1006962107
   Chondronikola M, 2014, DIABETES, V63, P4089, DOI 10.2337/db14-0746
   Ciciliot S, 2015, DIABETOLOGIA, V58, P2352, DOI 10.1007/s00125-015-3667-8
   Cinti S, 2012, DIS MODEL MECH, V5, P588, DOI 10.1242/dmm.009662
   Claussnitzer M, 2015, NEW ENGL J MED, V373, P895, DOI 10.1056/NEJMoa1502214
   Costantino S, 2016, J PHYSIOL-LONDON, V594, P2061, DOI 10.1113/JP270538
   Cree MG, 2004, J CLIN ENDOCR METAB, V89, P3864, DOI 10.1210/jc.2003-031986
   Curtis JM, 2010, DIABETES, V59, P1132, DOI 10.2337/db09-1105
   Cybulski N, 2009, P NATL ACAD SCI USA, V106, P9902, DOI 10.1073/pnas.0811321106
   Cypess AM, 2015, CELL METAB, V21, P33, DOI 10.1016/j.cmet.2014.12.009
   Cypess AM, 2009, NEW ENGL J MED, V360, P1509, DOI 10.1056/NEJMoa0810780
   Daval M, 2005, J BIOL CHEM, V280, P25250, DOI 10.1074/jbc.M414222200
   del Rincon JP, 2007, DIABETES, V56, P1638, DOI 10.2337/db06-0299
   Demozay D, 2008, DIABETES, V57, P1216, DOI 10.2337/db07-0389
   Ding JZ, 2009, AM J CLIN NUTR, V90, P499, DOI 10.3945/ajcn.2008.27358
   Dong M, 2013, CELL METAB, V18, P118, DOI 10.1016/j.cmet.2013.06.003
   Fabbrini E, 2015, J CLIN INVEST, V125, P787, DOI 10.1172/JCI78425
   Fabbrini E, 2009, P NATL ACAD SCI USA, V106, P15430, DOI 10.1073/pnas.0904944106
   Fadini GP, 2011, AGING CELL, V10, P10, DOI 10.1111/j.1474-9726.2010.00642.x
   Fallo F, 2006, J CLIN ENDOCR METAB, V91, P454, DOI 10.1210/jc.2005-1733
   Fan HQ, 2007, ACTA PHARMACOL SIN, V28, P410, DOI 10.1111/j.1745-7254.2007.00523.x
   Fedarko NS, 2011, CLIN GERIATR MED, V27, P27, DOI 10.1016/j.cger.2010.08.006
   Feraco A, 2013, J STEROID BIOCHEM, V137, P99, DOI 10.1016/j.jsbmb.2013.02.012
   Ferguson JE, 2013, ARAB J UROL, V11, P222, DOI 10.1016/j.aju.2013.07.009
   Fisher FM, 2012, GENE DEV, V26, P271, DOI 10.1101/gad.177857.111
   Fontana L, 2007, DIABETES, V56, P1010, DOI 10.2337/db06-1656
   Fontana L, 2015, CELL, V161, P106, DOI 10.1016/j.cell.2015.02.020
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gagnon A, 2001, J CELL PHYSIOL, V189, P14, DOI 10.1002/jcp.1132
   Ghosh AK, 2016, AGING-US, V8, P2525, DOI 10.18632/aging.101083
   Giordano A, 2016, NAT REV DRUG DISCOV, V15, P405, DOI 10.1038/nrd.2016.31
   Giorgio M, 2012, AGING CELL, V11, P162, DOI 10.1111/j.1474-9726.2011.00770.x
   Gong H, 2014, MOL MED REP, V10, P3296, DOI 10.3892/mmr.2014.2648
   Graja A, 2015, GERONTOLOGY, V61, P211, DOI 10.1159/000366557
   Greenstein AS, 2009, CIRCULATION, V119, P1661, DOI 10.1161/CIRCULATIONAHA.108.821181
   Grundy SM, 2015, EUR J CLIN INVEST, V45, P1209, DOI 10.1111/eci.12519
   Guo C, 2008, CIRCULATION, V117, P2253, DOI 10.1161/CIRCULATIONAHA.107.748640
   Habinowski SA, 2001, BIOCHEM BIOPH RES CO, V286, P852, DOI 10.1006/bbrc.2001.5484
   Haffner SM, 2000, INT J OBESITY, V24, pS56, DOI 10.1038/sj.ijo.0801279
   Haigis MC, 2010, MOL CELL, V40, P333, DOI 10.1016/j.molcel.2010.10.002
   Haim Y, 2015, AUTOPHAGY, V11, P2074, DOI 10.1080/15548627.2015.1094597
   Hardie DG, 2012, NAT REV MOL CELL BIO, V13, P251, DOI 10.1038/nrm3311
   HARMAN D, 1956, J GERONTOL, V11, P298, DOI 10.1093/geronj/11.3.298
   Harms M, 2013, NAT MED, V19, P1252, DOI 10.1038/nm.3361
   Harrison DE, 2009, NATURE, V460, P392, DOI 10.1038/nature08221
   Hirata A, 2009, CARDIOVASC RES, V84, P164, DOI 10.1093/cvr/cvp191
   Hondares E, 2010, CELL METAB, V11, P206, DOI 10.1016/j.cmet.2010.02.001
   Hotta Y, 2009, ENDOCRINOLOGY, V150, P4625, DOI 10.1210/en.2009-0119
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Iacobellis G, 2005, NAT CLIN PRACT CARD, V2, P134, DOI 10.1038/ncpcardio0132
   Irving BA, 2014, CURR OBES REP, V3, P235, DOI 10.1007/s13679-014-0091-1
   Ishii S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0112718
   Isidori AM, 1999, J CLIN ENDOCR METAB, V84, P3673, DOI 10.1210/jc.84.10.3673
   Jura M, 2016, AGE, V38, DOI 10.1007/s11357-016-9884-3
   Kalinkovich A, 2017, AGEING RES REV, V35, P200, DOI 10.1016/j.arr.2016.09.008
   Katz LEL, 2002, J CLIN ENDOCR METAB, V87, P2978, DOI 10.1210/jc.87.6.2978
   Kawano Jordan, 2009, J Cardiometab Syndr, V4, P44, DOI 10.1111/j.1559-4572.2008.00030.x
   Kelekar A, 2005, ANN NY ACAD SCI, V1066, P259, DOI 10.1196/annals.1363.015
   Kenchaiah S, 2002, NEW ENGL J MED, V347, P305, DOI 10.1056/NEJMoa020245
   Khan UI, 2014, OBESITY, V22, P786, DOI 10.1002/oby.20139
   Kim JH, 2014, ENDOCR J, V61, P1055, DOI 10.1507/endocrj.EJ14-0262
   Kovsan J, 2011, J CLIN ENDOCR METAB, V96, pE268, DOI 10.1210/jc.2010-1681
   Kumar A, 2010, DIABETES, V59, P1397, DOI 10.2337/db09-1061
   Kusminski CM, 2012, TRENDS ENDOCRIN MET, V23, P435, DOI 10.1016/j.tem.2012.06.004
   Laplante M, 2012, CELL, V149, P274, DOI 10.1016/j.cell.2012.03.017
   Lee P, 2014, DIABETES, V63, P3686, DOI 10.2337/db14-0513
   Lizcano F, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/757461
   Luyten W, 2016, BIOGERONTOLOGY, V17, P771, DOI 10.1007/s10522-016-9644-x
   Lymperopoulos A, 2013, CIRC RES, V113, P739, DOI 10.1161/CIRCRESAHA.113.300308
   Ma XR, 2014, P NATL ACAD SCI USA, V111, P14289, DOI 10.1073/pnas.1407640111
   Maixner N, 2012, OBESITY FACTS, V5, P710, DOI 10.1159/000343983
   Mammi C, 2012, INT J ENDOCRINOL, V2012, DOI 10.1155/2012/789653
   Maneschi E, 2016, MOL CELL ENDOCRINOL, V424, P50, DOI 10.1016/j.mce.2016.01.015
   Martinez-Lopez N, 2013, EMBO REP, V14, P795, DOI 10.1038/embor.2013.111
   Marzolla V, 2014, STEROIDS, V91, P46, DOI 10.1016/j.steroids.2014.05.001
   Mathis AS, 2004, AM J HEALTH-SYST PH, V61, P565, DOI 10.1093/ajhp/61.6.565
   Matsushita M, 2014, INT J OBESITY, V38, P812, DOI 10.1038/ijo.2013.206
   Mattison JA, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms14063
   Mauvais-Jarvis F, 2013, ENDOCR REV, V34, P309, DOI 10.1210/er.2012-1055
   McDonald RB, 1999, J BIOENERG BIOMEMBR, V31, P507, DOI 10.1023/A:1005404708710
   McGavock JM, 2007, CIRCULATION, V116, P1170, DOI 10.1161/CIRCULATIONAHA.106.645614
   Mennes E, 2014, J GERONTOL A-BIOL, V69, P1060, DOI 10.1093/gerona/glt156
   Michalakis K, 2013, METABOLISM, V62, P1341, DOI 10.1016/j.metabol.2013.05.019
   Migliaccio E, 2006, ANTIOXID REDOX SIGN, V8, P600, DOI 10.1089/ars.2006.8.600
   Miljkovic I, 2016, OBESITY, V24, P476, DOI 10.1002/oby.21328
   Miljkovic N, 2015, ANN REHABIL MED-ARM, V39, P155, DOI 10.5535/arm.2015.39.2.155
   Mitschke MM, 2013, FASEB J, V27, P1621, DOI 10.1096/fj.12-221580
   Mizushima N, 2011, CELL, V147, P728, DOI 10.1016/j.cell.2011.10.026
   Mueller E, 2016, FRONT ENDOCRINOL, V7, DOI 10.3389/fendo.2016.00019
   Murata Y, 2011, J NUTR METAB, V2011, DOI 10.1155/2011/981315
   Nakae J, 2003, DEV CELL, V4, P119, DOI 10.1016/S1534-5807(02)00401-X
   Natalicchio A, 2015, DIABETOLOGIA, V58, P1260, DOI 10.1007/s00125-015-3563-2
   Nedergaard J, 2010, CELL METAB, V11, P268, DOI 10.1016/j.cmet.2010.03.007
   Newgard CB, 2014, J GERONTOL A-BIOL, V69, pS21, DOI 10.1093/gerona/glu058
   Nisoli E, 2000, P NATL ACAD SCI USA, V97, P8033, DOI 10.1073/pnas.97.14.8033
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Ogorodnikova AD, 2013, OBESITY, V21, P1726, DOI 10.1002/oby.20200
   Andrade JMO, 2014, NUTRITION, V30, P915, DOI 10.1016/j.nut.2013.11.016
   Palmer AK, 2016, EXP GERONTOL, V86, P97, DOI 10.1016/j.exger.2016.02.013
   Palmer BF, 2015, MOL CELL ENDOCRINOL, V402, P113, DOI 10.1016/j.mce.2014.11.029
   Palmieri VO, 2006, J NUTR, V136, P3022, DOI 10.1093/jn/136.12.3022
   Paneni F, 2014, ATHEROSCLEROSIS, V236, P426, DOI 10.1016/j.atherosclerosis.2014.07.027
   Paneni F, 2012, CIRC RES, V111, P278, DOI 10.1161/CIRCRESAHA.112.266593
   Parisi V, 2016, CIRC RES, V118, P1244, DOI 10.1161/CIRCRESAHA.115.307765
   Pfluger PT, 2008, P NATL ACAD SCI USA, V105, P9793, DOI 10.1073/pnas.0802917105
   Picard F, 2004, NATURE, V429, P771, DOI 10.1038/nature02583
   Polager S, 2008, ONCOGENE, V27, P4860, DOI 10.1038/onc.2008.117
   Polak P, 2008, CELL METAB, V8, P399, DOI 10.1016/j.cmet.2008.09.003
   Poulsen MM, 2013, DIABETES, V62, P1186, DOI 10.2337/db12-0975
   Qiang L, 2012, CELL, V150, P620, DOI 10.1016/j.cell.2012.06.027
   Qiao LP, 2006, J BIOL CHEM, V281, P39915, DOI 10.1074/jbc.M607215200
   Ramsey JJ, 2014, J GERONTOL A-BIOL, V69, P1177, DOI 10.1093/gerona/glt198
   Ranieri SC, 2013, VITAM HORM, V91, P219, DOI 10.1016/B978-0-12-407766-9.00009-2
   Ranieri SC, 2010, P NATL ACAD SCI USA, V107, P13420, DOI 10.1073/pnas.1008647107
   Rao PM, 2013, NAT REV ENDOCRINOL, V9, P479, DOI 10.1038/nrendo.2013.122
   Reilly SM, 2013, NAT MED, V19, P313, DOI 10.1038/nm.3082
   Reuben A, 2001, LIVER TRANSPLANT, V7, pS13, DOI 10.1053/jlts.2001.29167
   Riera CE, 2016, ANNU REV BIOCHEM, V85, P35, DOI 10.1146/annurev-biochem-060815-014451
   Rogers NH, 2012, AGING CELL, V11, P1074, DOI 10.1111/acel.12010
   Rolland Y, 2008, J NUTR HEALTH AGING, V12, P433, DOI 10.1007/BF02982704
   Ryter SW, 2014, CURR OPIN CLIN NUTR, V17, P329, DOI 10.1097/MCO.0000000000000068
   Saito M, 2009, DIABETES, V58, P1526, DOI 10.2337/db09-0530
   Salminen A, 2012, AGEING RES REV, V11, P230, DOI 10.1016/j.arr.2011.12.005
   Sanada K, 2012, EUR J CLIN NUTR, V66, P1093, DOI 10.1038/ejcn.2012.43
   Sattler FR, 2013, BEST PRACT RES CL EN, V27, P541, DOI 10.1016/j.beem.2013.05.003
   Schrauwen P, 2007, P NUTR SOC, V66, P33, DOI 10.1017/S0029665107005277
   Seals DR, 2004, DIABETES, V53, P276, DOI 10.2337/diabetes.53.2.276
   Sidossis L, 2015, J CLIN INVEST, V125, P478, DOI 10.1172/JCI78362
   Singh R, 2009, J CLIN INVEST, V119, P3329, DOI 10.1172/JCI39228
   Slutsky N, 2016, INT J OBESITY, V40, P912, DOI 10.1038/ijo.2016.5
   Smith TJ, 2010, PHARMACOL REV, V62, P199, DOI 10.1124/pr.109.002469
   Snel M, 2012, INT J ENDOCRINOL, V2012, DOI 10.1155/2012/983814
   Song XM, 2002, DIABETOLOGIA, V45, P56, DOI 10.1007/s125-002-8245-8
   Soussi H, 2015, DIABETES, V64, P3452, DOI 10.2337/db14-1933
   Stefanska A, 2015, ADV CLIN CHEM, V72, P1, DOI 10.1016/bs.acc.2015.07.001
   Stenholm S, 2008, CURR OPIN CLIN NUTR, V11, P693, DOI 10.1097/MCO.0b013e328312c37d
   Suba Z, 2012, PATHOL ONCOL RES, V18, P123, DOI 10.1007/s12253-011-9466-8
   Tamori Y, 2002, DIABETES, V51, P2045, DOI 10.2337/diabetes.51.7.2045
   Tazearslan C, 2011, AGING CELL, V10, P551, DOI 10.1111/j.1474-9726.2011.00697.x
   Tchkonia T, 2010, AGING CELL, V9, P667, DOI 10.1111/j.1474-9726.2010.00608.x
   Timmers S, 2011, CELL METAB, V14, P612, DOI 10.1016/j.cmet.2011.10.002
   Tormos KV, 2011, CELL METAB, V14, P537, DOI 10.1016/j.cmet.2011.08.007
   Traish AM, 2015, REV ENDOCR METAB DIS, V16, P249, DOI 10.1007/s11154-015-9323-2
   Trayhurn Paul, 2011, Archives of Physiology and Biochemistry, V117, P47, DOI 10.3109/13813455.2010.535835
   Urfer SR, 2017, GEROSCIENCE, V39, P117, DOI 10.1007/s11357-017-9972-z
   Valle A, 2010, AGING CELL, V9, P882, DOI 10.1111/j.1474-9726.2010.00613.x
   van Heemst D, 2010, AGING DIS, V1, P147
   Véniant MM, 2015, CELL METAB, V21, P731, DOI 10.1016/j.cmet.2015.04.019
   Villarroya F, 2013, CELL METAB, V17, P638, DOI 10.1016/j.cmet.2013.02.020
   Viollet B, 2012, CLIN SCI, V122, P253, DOI 10.1042/CS20110386
   Wang S, 2015, INT J OBESITY, V39, P967, DOI 10.1038/ijo.2015.23
   Wannamethee SG, 2015, P NUTR SOC, V74, P405, DOI 10.1017/S002966511500169X
   Xie QH, 2015, J CELL MOL MED, V19, P986, DOI 10.1111/jcmm.12487
   Xu SH, 2014, AGING DIS, V5, P263, DOI 10.14336/AD.2014.0500263
   Yakar S, 2001, DIABETES, V50, P1110, DOI 10.2337/diabetes.50.5.1110
   Yanovski SZ, 2002, NEW ENGL J MED, V346, P591, DOI 10.1056/NEJMra012586
   Yao YX, 2013, SCI SIGNAL, V6, DOI 10.1126/scisignal.2003295
   Yoneshiro T, 2013, J CLIN INVEST, V123, P3404, DOI 10.1172/JCI67803
   Zhang CB, 2013, AM J PHYSIOL-ENDOC M, V305, pE530, DOI 10.1152/ajpendo.00640.2012
   Zhang Y, 2009, P NATL ACAD SCI USA, V106, P19860, DOI 10.1073/pnas.0906048106
   Zhou S, 2011, CIRC RES, V109, P639, DOI 10.1161/CIRCRESAHA.111.243592
   Zhu M, 2007, EXP GERONTOL, V42, P733, DOI 10.1016/j.exger.2007.05.011
   Zoncu R, 2011, NAT REV MOL CELL BIO, V12, P21, DOI 10.1038/nrm3025
NR 196
TC 56
Z9 57
U1 0
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD OCT
PY 2017
VL 31
IS 10
BP 4240
EP 4255
DI 10.1096/fj.201601125RRR
PG 16
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA FK3PF
UT WOS:000413397400005
PM 28705812
DA 2025-06-11
ER

PT J
AU Keita, AD
   Judd, SE
   Howard, VJ
   Carson, AP
   Ard, JD
   Fernandez, JR
AF Keita, Akilah Dulin
   Judd, Suzanne E.
   Howard, Virginia J.
   Carson, April P.
   Ard, Jamy D.
   Fernandez, Jose R.
TI Associations of neighborhood area level deprivation with the metabolic
   syndrome and inflammation among middle- and older- age adults
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Neighborhoods; Socioeconomic factors; Metabolic syndrome; Cardiovascular
   disease
ID DISEASE RISK-FACTORS; CARDIOVASCULAR-DISEASE; SOCIOECONOMIC-STATUS;
   PERCEIVED STRESS; US ADULTS; HEALTH; HEART; ATHEROSCLEROSIS; COHORT;
   STROKE
AB Background: The study examines the association of neighborhood socioeconomic deprivation and metabolic syndrome with inflammation.
   Methods: The analysis included 19, 079 black and white participants from the REasons for Geographic And Racial Differences in Stroke Study who were age > 45 years at baseline. Logistic regression examined whether neighborhood deprivation was associated with increased odds of METS and CRP-MetS.
   Results: Among black adults, residing in the most deprived neighborhoods was associated with increased odds of obesity (p < .01), lower HDL (p < .001), high blood pressure (p < .01), elevated fasting glucose (p < .001), inflammation (p < .01), and CRP-MetS (p < .001). Among white adults, neighborhood deprivation was associated with higher waist circumference (p < .001), lower HDL (p < .001), higher triglycerides (p < .01), higher glucose (p < .001), higher BMI (p < .0001), higher blood pressure (p = .01), METS (p < .001), inflammation (p < .01) and CRP-MetS (p < .001).
   Conclusions: These findings highlight the role of neighborhood socioeconomic deprivation on METS and CRP-MetS for black and white adults. Interventions tailored to address the contextual effects of deprived neighborhoods may reduce the observed neighborhood disparities.
C1 [Keita, Akilah Dulin] Brown Univ, Inst Community Hlth Promot, Providence, RI 02912 USA.
   [Judd, Suzanne E.] Univ Alabama Birmingham, Dept Biostat, Birmingham, AL 35205 USA.
   [Howard, Virginia J.; Carson, April P.] Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL 35205 USA.
   [Ard, Jamy D.] Wake Forest Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC USA.
   [Fernandez, Jose R.] Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35205 USA.
C3 Brown University; University of Alabama System; University of Alabama
   Birmingham; University of Alabama System; University of Alabama
   Birmingham; Wake Forest University; University of Alabama System;
   University of Alabama Birmingham
RP Keita, AD (corresponding author), Brown Univ, Inst Community Hlth Promot, Box G-S121-8, Providence, RI 02912 USA.
EM akilah_keita@brown.edu
OI Howard, Virginia/0000-0003-4912-9975; Carson, April/0000-0002-7970-6756;
   Ard, Jamy/0000-0002-1643-6795
FU National Institutes of Health
FX National Institutes of Health.
CR Andersen AF, 2008, DIABETIC MED, V25, P1462, DOI 10.1111/j.1464-5491.2008.02594.x
   Auchincloss AH, 2007, AM J EPIDEMIOL, V165, P389, DOI 10.1093/aje/kwk028
   Bak CK, 2012, EUR J PUBLIC HEALTH, V22, P787, DOI 10.1093/eurpub/cks004
   Bird CE, 2010, J EPIDEMIOL COMMUN H, V64, P860, DOI 10.1136/jech.2008.084814
   Chaix B, 2010, HYPERTENSION, V55, P769, DOI 10.1161/HYPERTENSIONAHA.109.143206
   Chichlowska KL, 2008, PSYCHOSOM MED, V70, P986, DOI 10.1097/PSY.0b013e318183a491
   Clark CR, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0063254
   Coogan PF, 2010, OBESITY, V18, P2064, DOI 10.1038/oby.2010.69
   Cubbin C, 2006, SCAND J PUBLIC HEALT, V34, P228, DOI 10.1080/14034940500327935
   Elovainio M, 2011, AM J EPIDEMIOL, V174, P779, DOI 10.1093/aje/kwr149
   Geronimus Arline T., 1992, Ethnicity and Disease, V2, P207
   Glass TA, 2006, AM J PREV MED, V31, P455, DOI 10.1016/j.amepre.2006.07.028
   Gruenewald TL, 2009, SOC SCI MED, V69, P451, DOI 10.1016/j.socscimed.2009.05.018
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Heidenreich PA, 2011, CIRCULATION, V123, P933, DOI 10.1161/CIR.0b013e31820a55f5
   Howard VJ, 2005, NEUROEPIDEMIOLOGY, V25, P135, DOI 10.1159/000086678
   Keita AD, 2011, J NUTR EDUC BEHAV, V43, P244, DOI 10.1016/j.jneb.2009.07.004
   King KE, 2011, PSYCHOSOM MED, V73, P572, DOI 10.1097/PSY.0b013e318227b062
   LANSKA DJ, 1995, STROKE, V26, P1145, DOI 10.1161/01.STR.26.7.1145
   Li J, 2012, INT J ENV RES PUB HE, V9, P391, DOI 10.3390/ijerph9020391
   Liu JK, 2013, OBESITY, V21, P644, DOI 10.1002/oby.20265
   Ludwig J, 2011, NEW ENGL J MED, V365, P1509, DOI 10.1056/NEJMsa1103216
   Maes M, 1998, CYTOKINE, V10, P313, DOI 10.1006/cyto.1997.0290
   Matheson FI, 2010, J EPIDEMIOL COMMUN H, V64, P705, DOI 10.1136/jech.2008.083303
   McDade TW, 2006, PSYCHOSOM MED, V68, P376, DOI 10.1097/01.psy.0000221371.43607.64
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   Merkin SS, 2009, ANN EPIDEMIOL, V19, P194, DOI 10.1016/j.annepidem.2008.12.006
   Muennig P, 2007, PREV MED, V45, P35, DOI 10.1016/j.ypmed.2007.04.005
   Myers HF, 2009, J BEHAV MED, V32, P9, DOI 10.1007/s10865-008-9181-4
   Nazmi A, 2010, HEALTH PLACE, V16, P1104, DOI 10.1016/j.healthplace.2010.07.001
   Nordstrom CK, 2004, SOC SCI MED, V59, P2139, DOI 10.1016/j.socscimed.2004.03.017
   Onat A, 2014, EXPERT REV CARDIOVAS, V12, P667, DOI 10.1586/14779072.2014.910114
   Onat A, 2014, CURR PHARM DESIGN, V20, P575, DOI 10.2174/138161282004140213145551
   Otto MCD, 2012, AM J CLIN NUTR, V96, P397, DOI 10.3945/ajcn.112.037770
   Rifai N, 1999, CLIN CHEM, V45, P2136
   Rod NH, 2009, J INTERN MED, V266, P467, DOI 10.1111/j.1365-2796.2009.02124.x
   Roger VL, 2012, CIRCULATION, V125, P188, DOI 10.1161/CIR.0b013e3182456d46
   Roux AVD, 2001, ANN EPIDEMIOL, V11, P395, DOI 10.1016/S1047-2797(01)00221-6
   Roux AVD, 2003, J URBAN HEALTH, V80, P569, DOI 10.1093/jurban/jtg065
   Smith GD, 1998, J EPIDEMIOL COMMUN H, V52, P399, DOI 10.1136/jech.52.6.399
   Suzuki T, 2008, CIRC-HEART FAIL, V1, P242, DOI 10.1161/CIRCHEARTFAILURE.108.785485
   van Lenthe FJ, 2002, INT J OBESITY, V26, P234, DOI 10.1038/sj.ijo.0801841
   Winkleby M, 2007, AM J PREV MED, V32, P97, DOI 10.1016/j.amepre.2006.10.002
NR 43
TC 66
Z9 74
U1 0
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD DEC 23
PY 2014
VL 14
AR 1319
DI 10.1186/1471-2458-14-1319
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA CA0LS
UT WOS:000348609900001
PM 25539758
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Akhavanfar, R
   Hojati, A
   Kahrizi, MS
   Farhangi, MA
   Ardekani, AM
AF Akhavanfar, Roozbeh
   Hojati, Ali
   Kahrizi, Mohammad Saeed
   Farhangi, Mahdieh Abbasalizad
   Ardekani, Abnoos Mokhtari
TI RETRACTED: Adherence to lifelines diet score and risk factors of
   metabolic syndrome among overweight and obese adults: A cross-sectional
   study (Retracted Article)
SO FRONTIERS IN NUTRITION
LA English
DT Article; Retracted Publication
DE lifeline diet score; metabolic syndivme; obesity; diabetes;
   cardiovascular diseae
ID HEALTHY EATING INDEX; BLOOD-PRESSURE; OXIDATIVE STRESS; MEDITERRANEAN
   DIET; RELATIVE VALIDITY; PHYSICAL-ACTIVITY; WHOLE GRAINS; QUALITY;
   HYPERTENSION; FRUIT
AB BackgroundMetabolic syndrome (MetS) is one of the most significant public health issues worldwide, and diet quality is an important controllable environmental factor influencing the incidence of MetS. Numerous dietary scores have been established to assess compliance with dietary recommendations or eating patterns, many of which are not entirely food-based. Hence, Lifelines Diet Score (LLDS) was developed in response to the shortcomings of existing tools. This study aimed to assess any possible links between total food quality and cardiometabolic risk factors among overweight and obese adults. MethodsThis cross-sectional study included 338 overweight and obese individuals [body mass index (BMI) > 25 kg/m(2)] aged 20-50 years in Tabriz, Iran. To collect dietary data, we used a validated semi-quantitative Food Frequency Questionnaire (FFQ) for Iranian population. Enzymatic-colorimetric methods were used to assess serum glucose and lipids, and enzyme-linked immunosorbent assay (ELISA) kits were used to measure insulin levels. In addition, the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and Quantitative Insulin Sensitivity Check Index (QUICKI) were calculated. ResultsBMI and hip circumference (HC) were significantly different (P < 0.05) amongst LLDS tertiles. Adherence to the highest tertile of LLDS was associated with lower SBP, and the subjects in higher LLDS tertiles significantly had lower systolic blood pressure (SBP) (P = 0.04). Triglyceride (TG) levels were also lower in the third tertile of LLDS with a near-significant P-value (P = 0.05). ConclusionAccording to our results, a higher diet quality score, determined by LLDS, can be associated with a lower risk of MetS. Further experimental and longitudinal studies are needed to better understand this relationship.
C1 [Akhavanfar, Roozbeh] Isfahan Univ Med Sci, Sch Med, Esfahan, Iran.
   [Hojati, Ali] Tabriz Univ Med Sci, Fac Nutr, Dept Community Nutr, Tabriz, Iran.
   [Kahrizi, Mohammad Saeed] Alborz Univ Med Sci, Karaj, Iran.
   [Farhangi, Mahdieh Abbasalizad] Tabriz Univ Med Sci, Tabriz Hlth Serv Management Res Ctr, Tabriz, Iran.
   [Ardekani, Abnoos Mokhtari] Kerman Univ Med Sci, Inst Basic & Clin Physiol Sci, Endocrinoligy & Metab Res Ctr, Kerman, Iran.
   [Ardekani, Abnoos Mokhtari] Kerman Univ Med Sci, Physiol Res Ctr, Kerman, Iran.
C3 Isfahan University of Medical Sciences; Tabriz University of Medical
   Science; Alborz University of Medical Sciences; Tabriz University of
   Medical Science; Kerman University of Medical Sciences; Kerman
   University of Medical Sciences
RP Farhangi, MA (corresponding author), Tabriz Univ Med Sci, Tabriz Hlth Serv Management Res Ctr, Tabriz, Iran.; Ardekani, AM (corresponding author), Kerman Univ Med Sci, Inst Basic & Clin Physiol Sci, Endocrinoligy & Metab Res Ctr, Kerman, Iran.; Ardekani, AM (corresponding author), Kerman Univ Med Sci, Physiol Res Ctr, Kerman, Iran.
EM abbasalizad_m@yahoo.com; amokhtari@kmu.ac.ir
RI Farhangi, Mahdieh/AAC-6758-2019; Kahrizi, Mohammad saeed/GOE-4170-2022;
   Mokhtari, Abnoos/GYV-5829-2022
FU Tabriz University of Medical Sciences;  [70010]
FX Funding This study received a grant from the Vice Chancellor for
   Research and Technology, Tabriz University of Medical Sciences, Iran
   (Identifier: IR.TBZMED.REC.1401.444; Grant No. 70010).
CR Abdollahi M., 2014, Nutr. Food Sci. Res, V1, P19, DOI DOI 10.1051/E3SC0NF/20130141037
   Aburto NJ, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f1378
   AlEssa HB, 2017, AM J CLIN NUTR, V105, P432, DOI 10.3945/ajcn.116.143016
   Martínez-González MA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043134
   Borgi L, 2016, HYPERTENSION, V67, P288, DOI 10.1161/HYPERTENSIONAHA.115.06497
   Brand-Miller J, 2009, J AM COLL NUTR, V28, p446S, DOI 10.1080/07315724.2009.10718110
   Chandra A.S., 2020, INT J PHARM RES TECH, V10, P74
   Cho YA, 2021, NUTRIENTS, V13, DOI 10.3390/nu13093098
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Coble JP, 2015, AM J PHYSIOL-REG I, V308, pR238, DOI 10.1152/ajpregu.00486.2014
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   D'Elia L, 2018, J HYPERTENS, V36, P734, DOI 10.1097/HJH.0000000000001604
   Desroches S, 2007, APPL PHYSIOL NUTR ME, V32, P23, DOI 10.1139/h06-095
   Drewnowski A, 2009, J AM COLL NUTR, V28, P22, DOI 10.1080/07315724.2009.10719757
   Esfahani FH, 2010, J EPIDEMIOL, V20, P150, DOI 10.2188/jea.JE20090083
   Esposito K, 2013, REV ENDOCR METAB DIS, V14, P255, DOI 10.1007/s11154-013-9253-9
   Fantin F, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102542
   Farhadnejad H, 2021, INT J PREVENTIVE MED, V12, DOI 10.4103/ijpvm.IJPVM_108_20
   Farhangi MA, 2020, LIFESTYLE GENOM, V13, P1, DOI 10.1159/000503789
   Farhangi MA, 2020, EAT WEIGHT DISORD-ST, V25, P1049, DOI 10.1007/s40519-019-00729-1
   Farmanfarma KK, 2019, DIABETES METAB SYND, V13, P792, DOI 10.1016/j.dsx.2018.11.055
   Feng RN, 2015, SCI REP-UK, V5, DOI 10.1038/srep16919
   Flint AJ, 2009, AM J CLIN NUTR, V90, P493, DOI 10.3945/ajcn.2009.27460
   Gallegos-Gonzalez G, 2021, AM J HEALTH BEHAV, V45, P1091, DOI 10.5993/AJHB.45.6.12
   Ghafarpour M., 1999, MANUAL HOUSEHOLD MEA
   Grillo A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11091970
   Guenther PM, 2013, J ACAD NUTR DIET, V113, P569, DOI 10.1016/j.jand.2012.12.016
   Guo XG, 2006, FASEB J, V20, pA577
   Harrington JM, 2013, AM J HYPERTENS, V26, P1311, DOI 10.1093/ajh/hpt106
   Hasan Kadhim A, 2022, Arch Razi Inst, V77, P1805, DOI [10.22092/ari.2022.358365.2210, 10.22092/ARI.2022.358365.2210]
   Hu EA, 2020, J NUTR, V150, P312, DOI 10.1093/jn/nxz218
   Jontony N, 2020, AM J HEALTH BEHAV, V44, P432, DOI 10.5993/AJHB.44.4.6
   Juraschek SP, 2012, AM J CLIN NUTR, V95, P1079, DOI 10.3945/ajcn.111.027995
   Kamolthip R, 2021, AM J HEALTH BEHAV, V45, P828, DOI 10.5993/AJHB.45.5.3
   KENNEDY ET, 1995, J AM DIET ASSOC, V95, P1103, DOI 10.1016/S0002-8223(95)00300-2
   Kesse-Guyot E, 2013, NUTR METAB CARDIOVAS, V23, P677, DOI 10.1016/j.numecd.2012.02.005
   Khani-juyabad S, 2021, EAT WEIGHT DISORD-ST, V26, P1639, DOI 10.1007/s40519-020-00985-6
   Khodarahmi M, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0219193
   Leman MA, 2021, AM J HEALTH BEHAV, V45, P268, DOI 10.5993/AJHB.45.2.7
   Li BR, 2016, J CLIN HYPERTENS, V18, P468, DOI 10.1111/jch.12777
   Macready AL, 2014, AM J CLIN NUTR, V99, P479, DOI 10.3945/ajcn.113.074237
   Manaf MRA, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-87248-1
   Martínez-González MA, 2015, PROG CARDIOVASC DIS, V58, P50, DOI 10.1016/j.pcad.2015.04.003
   Mirmiran P, 2010, PUBLIC HEALTH NUTR, V13, P654, DOI 10.1017/S1368980009991698
   Mohsen IH, 2022, Journal of Chemical Health Risks, V12, P523, DOI 10.22034/JCHR.2022.690774
   Mohseni-Takalloo S, 2014, J. Food Nutr. Res, V2, P155, DOI [DOI 10.12691/JFNR-2-4-4, 10.12691/jfnr-2-4-4]
   Monfort-Pires M, 2014, APPL PHYSIOL NUTR ME, V39, P497, DOI 10.1139/apnm-2013-0279
   Morris RC, 2016, CIRCULATION, V133, P881, DOI 10.1161/CIRCULATIONAHA.115.017923
   Newby PK, 2007, AM J CLIN NUTR, V86, P1745
   Nicklas TA, 2012, J NUTR, V142, P2112, DOI 10.3945/jn.112.164889
   Paul R., 2020, J NAT SCI BIOL MED, V11, P111, DOI [10.4103/jnsbm.JNSBM_205_19, DOI 10.4103/JNSBM.JNSBM_205_19]
   Rice-Evans C., 2003, Flavonoids in health and disease
   Rifai N., 2017, Tietz textbook of clinical chemistry and molecular diagnostics-e-book, V6th
   Roberts CK, 2002, CIRCULATION, V106, P2530, DOI 10.1161/01.CIR.0000040584.91836.0D
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Sangeetha T, 2020, J COMPL MED RES, V11, P1, DOI 10.5455/jcmr.2020.11.03.01
   Saraf-Bank S, 2017, EUR J CLIN NUTR, V71, P425, DOI 10.1038/ejcn.2016.173
   Sobhani SR, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.789692
   Sofi F, 2014, PUBLIC HEALTH NUTR, V17, P2769, DOI 10.1017/S1368980013003169
   Sohouli MH, 2022, INT J CLIN PRACT, V2022, DOI 10.1155/2022/7726126
   Sonestedt E, 2016, NUTRIENTS, V8, DOI 10.3390/nu8050274
   Takahashi H, 2011, HYPERTENS RES, V34, P1147, DOI 10.1038/hr.2011.105
   Tamai Y, 2011, AM J HYPERTENS, V24, P1215, DOI 10.1038/ajh.2011.133
   Tang DS, 2020, AM J HEALTH BEHAV, V44, P780, DOI 10.5993/AJHB.44.6.4
   Toft U, 2007, EUR J CLIN NUTR, V61, P270, DOI 10.1038/sj.ejcn.1602503
   Toh JY, 2013, CURR ATHEROSCLER REP, V15, DOI 10.1007/s11883-013-0368-y
   Tozoglu EO, 2021, ARCH CLIN PSYCHIAT, V48, P195, DOI 10.15761/0101-60830000000307
   TRICHOPOULOU A, 1995, BMJ-BRIT MED J, V311, P1457, DOI 10.1136/bmj.311.7018.1457
   Tzima N, 2007, LIPIDS HEALTH DIS, V6, DOI 10.1186/1476-511X-6-22
   Vinke PC, 2021, DIABETES CARE, V44, P1228, DOI 10.2337/dc20-2709
   Vinke PC, 2020, ECLINICALMEDICINE, V19, DOI 10.1016/j.eclinm.2019.100252
   Vinke PC, 2018, EUR J CLIN NUTR, V72, P1111, DOI 10.1038/s41430-018-0205-z
   Wang L, 2012, AM J HYPERTENS, V25, P180, DOI 10.1038/ajh.2011.186
   WHELTON PK, 1989, AM J CARDIOL, V63, pG26, DOI 10.1016/0002-9149(89)90215-4
   Wilson JLL, 2013, CLIN EXP NEPHROL, V17, P751, DOI 10.1007/s10157-013-0789-5
   Wissmann R, 2021, AM J HEALTH BEHAV, V45, P588, DOI 10.5993/AJHB.45.3.12
   Yu DX, 2018, DIABETES CARE, V41, P723, DOI 10.2337/dc17-1626
   Zamora D, 2011, DIABETES CARE, V34, P1183, DOI 10.2337/dc10-2041
NR 78
TC 9
Z9 9
U1 1
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD NOV 17
PY 2022
VL 9
AR 961468
DI 10.3389/fnut.2022.961468
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 6S0DP
UT WOS:000892668200001
PM 36466413
OA Green Published, gold
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Janus, A
   Szahidewicz-Krupska, E
   Mazur, G
   Doroszko, A
AF Janus, A.
   Szahidewicz-Krupska, E.
   Mazur, G.
   Doroszko, A.
TI Insulin Resistance and Endothelial Dysfunction Constitute a Common
   Therapeutic Target in Cardiometabolic Disorders
SO MEDIATORS OF INFLAMMATION
LA English
DT Review
ID TYPE-2 DIABETES-MELLITUS; ANGIOTENSIN-ALDOSTERONE SYSTEM; NITRIC-OXIDE
   SYNTHASE; PROTEIN-KINASE-C; MEDITERRANEAN DIET; OXIDATIVE STRESS;
   KAPPA-B; CARDIOVASCULAR RISK; ADIPOSE-TISSUE; GLUCOSE-UPTAKE
AB Insulin resistance and other risk factors for atherosclerosis, such as hypertension and hypercholesterolemia, promote endothelial dysfunction and lead to development of metabolic syndrome which constitutes an introduction to cardiovascular disease. The insulin resistance and endothelial dysfunction cross talk between each other by numerous metabolic pathways. Hence, targeting one of these pathologies with pleiotropic treatment exerts beneficial effect on another one. Combined and expletive treatment of hypertension, lipid disorders, and insulin resistance with nonpharmacological interventions and conventional pharmacotherapy may inhibit the transformation of metabolic disturbances to fully developed cardiovascular disease. This paper summarises the common therapeutic targets for insulin resistance, endothelial dysfunction, and vascular inflammatory reaction at molecular level and analyses the potential pleiotropic effects of drugs used currently in management of cardiovascular disease, metabolic syndrome, and diabetes.
C1 [Janus, A.; Szahidewicz-Krupska, E.; Mazur, G.; Doroszko, A.] Wroclaw Med Univ, Dept Internal Med Occupat Dis Hypertens & Clin On, Ulica Borowska 213, PL-50556 Wroclaw, Poland.
   [Janus, A.; Szahidewicz-Krupska, E.; Doroszko, A.] Integrated Cardiovasc Ctr Prov Specialist Hosp Wr, Res & Dev Dept, Ulica Kamienskiego 73A, PL-51124 Wroclaw, Poland.
C3 Wroclaw Medical University
RP Doroszko, A (corresponding author), Wroclaw Med Univ, Dept Internal Med Occupat Dis Hypertens & Clin On, Ulica Borowska 213, PL-50556 Wroclaw, Poland.; Doroszko, A (corresponding author), Integrated Cardiovasc Ctr Prov Specialist Hosp Wr, Res & Dev Dept, Ulica Kamienskiego 73A, PL-51124 Wroclaw, Poland.
EM adrian.doroszko@gmail.com
RI Janus, Agnieszka/E-7810-2016; Doroszko, Adrian/JJG-1097-2023
OI Doroszko, Adrian/0000-0001-5472-028X; Mazur,
   Grzegorz/0000-0001-6610-2008; Szahidewicz-Krupska,
   Ewa/0000-0002-4446-6991
CR [Anonymous], J CLIN ENDOCR METAB
   [Anonymous], WHO DRUG INFORM
   Arakawa M, 2010, DIABETES, V59, P1030, DOI 10.2337/db09-1694
   Aroor AR, 2013, ENDOCRINOLOGY, V154, P2501, DOI 10.1210/en.2013-1096
   Avogaro A, 2011, DIABETES CARE, V34, pS285, DOI 10.2337/dc11-s239
   Baker RG, 2011, CELL METAB, V13, P11, DOI 10.1016/j.cmet.2010.12.008
   Berg G, 2014, HORM MOL BIOL CLIN I, V17, P79, DOI 10.1515/hmbci-2013-0069
   Bosch J, 2006, NEW ENGL J MED, V355, P1551
   Bouchonville M, 2014, INT J OBESITY, V38, P423, DOI 10.1038/ijo.2013.122
   Briones AM, 2014, CURR VASC PHARMACOL, V12, P427, DOI 10.2174/1570161112666140423221319
   Brown MS, 2008, CELL METAB, V7, P95, DOI 10.1016/j.cmet.2007.12.009
   Campbell JE, 2013, CELL METAB, V17, P819, DOI 10.1016/j.cmet.2013.04.008
   Cusi K, 2000, J CLIN INVEST, V105, P311, DOI 10.1172/JCI7535
   Davignon J, 2004, CIRCULATION, V109, P27, DOI 10.1161/01.CIR.0000131515.03336.f8
   Davis BJ, 2006, DIABETES, V55, P496, DOI 10.2337/diabetes.55.02.06.db05-1064
   Del Prato S, 2009, DIABETIC MED, V26, P1185, DOI 10.1111/j.1464-5491.2009.02847.x
   Dicker D, 2011, DIABETES CARE, V34, pS276, DOI 10.2337/dc11-s229
   Dimmeler S, 1999, NATURE, V399, P601, DOI 10.1038/21224
   Economides PA, 2004, J CLIN ENDOCR METAB, V89, P740, DOI 10.1210/jc.2003-031116
   Erdogdu Ö, 2010, MOL CELL ENDOCRINOL, V325, P26, DOI 10.1016/j.mce.2010.04.022
   Eriksson L, 2015, BASIC CLIN PHARMACOL, V117, P15, DOI 10.1111/bcpt.12402
   Esposito K, 2014, DIABETES CARE, V37, P1824, DOI 10.2337/dc13-2899
   FERRI C, 1995, J CLIN ENDOCR METAB, V80, P829, DOI 10.1210/jc.80.3.829
   Foretz M, 2014, CELL METAB, V20, P953, DOI 10.1016/j.cmet.2014.09.018
   Gabriely I, 2002, ATHEROSCLEROSIS, V160, P115, DOI 10.1016/S0021-9150(01)00574-3
   Gage MC, 2013, ATHEROSCLEROSIS, V230, P131, DOI 10.1016/j.atherosclerosis.2013.06.017
   Giraud J, 2004, J BIOL CHEM, V279, P3447, DOI 10.1074/jbc.M308631200
   Hadjiyanni I, 2010, DIABETOLOGIA, V53, P730, DOI 10.1007/s00125-009-1643-x
   Hançer NJ, 2014, J BIOL CHEM, V289, P12467, DOI 10.1074/jbc.M114.554162
   Hartge Martin M, 2007, Diab Vasc Dis Res, V4, P84
   Hemmings BA, 2012, CSH PERSPECT BIOL, V4, DOI 10.1101/cshperspect.a011189
   Hermann C, 2000, ARTERIOSCL THROM VAS, V20, P402, DOI 10.1161/01.ATV.20.2.402
   Hsueh WA, 2003, AM J CARDIOL, V92, p10J, DOI 10.1016/S0002-9149(03)00611-8
   Hsueh WA, 2001, ARTERIOSCL THROM VAS, V21, P1891, DOI 10.1161/hq1201.100261
   Hsueh WA, 1999, AM J CARDIOL, V84, p21J
   Inoguchi T, 2000, DIABETES, V49, P1939, DOI 10.2337/diabetes.49.11.1939
   Inoue G, 1998, J BIOL CHEM, V273, P11548, DOI 10.1074/jbc.273.19.11548
   Jung KH, 2008, J MED FOOD, V11, P429, DOI 10.1089/jmf.2007.0107
   Kahn SE, 2006, NATURE, V444, P840, DOI 10.1038/nature05482
   Kaplan M, 2012, PHARMACOL THERAPEUT, V136, P175, DOI 10.1016/j.pharmthera.2012.08.002
   Kassan M, 2011, ARTERIOSCL THROM VAS, V31, P2534, DOI 10.1161/ATVBAHA.111.233262
   Keech A, 2005, LANCET, V366, P1849, DOI 10.1016/S0140-6736(05)67667-2
   Kellow NJ, 2013, EUR J CLIN NUTR, V67, P239, DOI 10.1038/ejcn.2012.220
   Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213
   Koh KK, 2004, CIRCULATION, V110, P3687, DOI 10.1161/01.CIR.0000143085.86697.13
   Koloverou E, 2014, METABOLISM, V63, P903, DOI 10.1016/j.metabol.2014.04.010
   Lawlor MA, 2001, J CELL SCI, V114, P2903
   Li H, 2011, INT J CARDIOL, V152, P218, DOI 10.1016/j.ijcard.2010.07.019
   Liu HB, 2009, J ENDOCRINOL, V201, P59, DOI 10.1677/JOE-08-0468
   Mancini GBJ, 1996, CIRCULATION, V94, P258, DOI 10.1161/01.CIR.94.3.258
   Manning BD, 2007, CELL, V129, P1261, DOI 10.1016/j.cell.2007.06.009
   Manrique C, 2009, MED CLIN N AM, V93, P569, DOI 10.1016/j.mcna.2009.02.014
   Mather K, 2001, J VASC RES, V38, P415, DOI 10.1159/000051074
   Mathew M, 2010, CARDIOVASC DIABETOL, V9, DOI 10.1186/1475-2840-9-9
   McCabe TJ, 2000, J BIOL CHEM, V275, P6123, DOI 10.1074/jbc.275.9.6123
   McGowan TA, 2006, CLIN J AM SOC NEPHRO, V1, P263, DOI 10.2215/CJN.00990905
   Miao BC, 2010, P NATL ACAD SCI USA, V107, P20126, DOI 10.1073/pnas.1004522107
   Montagnani M, 2002, J BIOL CHEM, V277, P1794, DOI 10.1074/jbc.M103728200
   Morbidelli L, 2003, CURR PHARM DESIGN, V9, P521, DOI 10.2174/1381612033391405
   Munir KM, 2013, AM J PHYSIOL-ENDOC M, V305, pE679, DOI 10.1152/ajpendo.00377.2013
   Muniyappa R, 2007, ENDOCR REV, V28, P463, DOI 10.1210/er.2007-0006
   Musicki B, 2005, P NATL ACAD SCI USA, V102, P11870, DOI 10.1073/pnas.0502488102
   Natali A, 2006, DIABETOLOGIA, V49, P434, DOI 10.1007/s00125-006-0141-7
   Ouchi N, 2011, NAT REV IMMUNOL, V11, P85, DOI 10.1038/nri2921
   Owen MR, 2000, BIOCHEM J, V348, P607, DOI 10.1042/0264-6021:3480607
   Perkins JM, 2008, CURR OPIN ENDOCRINOL, V15, P147, DOI 10.1097/MED.0b013e3282f7026f
   Polikandriotis JA, 2005, ARTERIOSCL THROM VAS, V25, P1810, DOI 10.1161/01.ATV.0000177805.65864.d4
   Price DL, 2001, J BIOL CHEM, V276, P48967, DOI 10.1074/jbc.M108196200
   Pueyo ME, 2000, ARTERIOSCL THROM VAS, V20, P645, DOI 10.1161/01.ATV.20.3.645
   Rask-Madsen C, 2012, ARTERIOSCL THROM VAS, V32, P2052, DOI 10.1161/ATVBAHA.111.241919
   Rubinfeld H, 2005, MOL BIOTECHNOL, V31, P151, DOI 10.1385/MB:31:2:151
   Scheen AJ, 2004, DIABETES METAB, V30, P487, DOI 10.1016/S1262-3636(07)70146-5
   Scirica BM, 2013, NEW ENGL J MED, V369, P1317, DOI 10.1056/NEJMoa1307684
   SELL DR, 1991, DIABETES METAB REV, V7, P239, DOI 10.1002/dmr.5610070404
   Shah Z, 2011, CIRCULATION, V124, P2339, DOI 10.1161/CIRCULATIONAHA.111.041418
   Snyder SH, 1999, NAT CELL BIOL, V1, pE95, DOI 10.1038/12093
   Sofi F, 2010, AM J CLIN NUTR, V92, P1189, DOI 10.3945/ajcn.2010.29673
   Suksomboon N, 2012, J CLIN PHARM THER, V37, P319, DOI 10.1111/j.1365-2710.2011.01295.x
   Taguchi A, 2008, ANNU REV PHYSIOL, V70, P191, DOI 10.1146/annurev.physiol.70.113006.100533
   Taniguchi CM, 2006, NAT REV MOL CELL BIO, V7, P85, DOI 10.1038/nrm1837
   Tocci G, 2011, AM J HYPERTENS, V24, P582, DOI 10.1038/ajh.2011.8
   Uribarri J, 2007, J GERONTOL A-BIOL, V62, P427, DOI 10.1093/gerona/62.4.427
   Ussher JR, 2012, ENDOCR REV, V33, P187, DOI 10.1210/er.2011-1052
   Van Puyvelde K, 2014, NUTR REV, V72, P638, DOI 10.1111/nure.12141
   Vlassara H, 2002, P NATL ACAD SCI USA, V99, P15596, DOI 10.1073/pnas.242407999
   Wautier JL, 2001, DIABETES METAB, V27, P535
   Wende AR, 2012, CURR HYPERTENS REP, V14, P517, DOI 10.1007/s11906-012-0307-2
   White WB, 2013, NEW ENGL J MED, V369, P1327, DOI 10.1056/NEJMoa1305889
   Withers DJ, 1998, NATURE, V391, P900, DOI 10.1038/36116
   Wong AKF, 2012, HEART FAIL CLIN, V8, P539, DOI 10.1016/j.hfc.2012.06.002
   Youngren JF, 2007, CELL MOL LIFE SCI, V64, P873, DOI 10.1007/s00018-007-6359-9
   Zheng XX, 2011, AM J CLIN NUTR, V94, P601, DOI 10.3945/ajcn.110.010926
NR 92
TC 176
Z9 184
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2016
VL 2016
AR 3634948
DI 10.1155/2016/3634948
PG 10
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA DQ2SQ
UT WOS:000379053700001
PM 27413253
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Dudzinska, D
   Boncler, M
   Watala, C
AF Dudzinska, Dominika
   Boncler, Magdalena
   Watala, Cezary
TI The cardioprotective power of leaves
SO ARCHIVES OF MEDICAL SCIENCE
LA English
DT Article
DE anti-oxidants; cardiovascular diseases; leaf extracts; polyphenols
ID GINKGO-BILOBA EXTRACT; BLOOD-PLATELET ADHESION; NETTLE URTICA-DIOICA;
   MORUS-ALBA L.; GREEN TEA; ANTIOXIDANT ACTIVITY; WITHANIA-SOMNIFERA;
   METABOLIC SYNDROME; PLANT-EXTRACTS; LEAF EXTRACT
AB Lack of physical activity, smoking and/or inappropriate diet can contribute to the increase of oxidative stress, in turn affecting the pathophysiology of cardiovascular diseases. Strong anti-oxidant properties of plant polyphenolic compounds might underlie their cardioprotective activity. This paper reviews recent findings on the anti-oxidant activity of plant leaf extracts and emphasizes their effects on blood platelets, leukocytes and endothelial cells - the targets orchestrating the development and progression of cardiovascular diseases. We also review the evidence linking supplementation with plant leaf extracts and the risk factors defining the metabolic syndrome. The data point to the importance of leaves as an alternative source of polyphenolic compounds in the human diet and their role in the prevention of cardiovascular diseases.
C1 [Dudzinska, Dominika; Boncler, Magdalena; Watala, Cezary] Med Univ Lodz, Dept Haemostasis & Haemostat Disorders, PL-92215 Lodz, Poland.
C3 Medical University Lodz
RP Dudzinska, D (corresponding author), Med Univ Lodz, Dept Haemostasis & Haemostat Disorders, Chair Biomed Sci, 6-8 Mazowiecka St, PL-92215 Lodz, Poland.
EM dom.dudzinska@gmail.com
RI Watala, Cezary/ABF-4863-2020; BONCLER, MAGDALENA/S-9252-2016; Dudzińska,
   Dominika/D-3693-2015
OI BONCLER, MAGDALENA/0000-0002-4860-5338
FU project "FLAWO-PIRYNA" - European Regional Development Fund within the
   framework of the Innovative Economy Programme
   [UDA-POIG.01.03.01-10-129/08-00]
FX This work was supported by the project "FLAWO-PIRYNA",
   UDA-POIG.01.03.01-10-129/08-00, financed by the European Regional
   Development Fund within the framework of the Innovative Economy
   Programme 2007-2013.
CR Agarwal KC, 1996, MED RES REV, V16, P111, DOI 10.1002/(SICI)1098-1128(199601)16:1<111::AID-MED4>3.0.CO;2-5
   Aiyegoro OA, 2010, FOLIA MICROBIOL, V55, P176, DOI 10.1007/s12223-010-0026-5
   Aiyegoro OA, 2010, BMC COMPLEM ALTERN M, V10, DOI 10.1186/1472-6882-10-21
   Alam N, 2012, BMC COMPLEM ALTERN M, V12, DOI 10.1186/1472-6882-12-175
   Alam N, 2011, BMC COMPLEM ALTERN M, V11, DOI 10.1186/1472-6882-11-65
   Alvarez B, 2003, AMINO ACIDS, V25, P295, DOI 10.1007/s00726-003-0018-8
   Andallu B, 2009, INT J DIABETES DEV C, V29, P123, DOI 10.4103/0973-3930.54289
   [Anonymous], ZYWNOSC NAUKA TE S43
   [Anonymous], 2011, EVIDENCE BASED COMPL
   [Anonymous], FOOD CHEM
   [Anonymous], FOOD CHEM
   Anty R, 2007, GASTROEN CLIN BIOL, V31, P1127, DOI 10.1016/S0399-8320(07)78350-1
   Arts MJTJ, 2004, FOOD CHEM TOXICOL, V42, P45, DOI 10.1016/j.fct.2003.08.004
   BANKSON DD, 1993, CLIN LAB MED, V13, P463, DOI 10.1016/S0272-2712(18)30449-9
   Barroso I, 1999, NATURE, V402, P880, DOI 10.1038/47254
   Barton BE, 1996, MED RES REV, V16, P87, DOI 10.1002/(SICI)1098-1128(199601)16:1<87::AID-MED3>3.3.CO;2-5
   Benzie IFF, 1996, ANAL BIOCHEM, V239, P70, DOI 10.1006/abio.1996.0292
   Bhattacharya S, 2009, FOOD CHEM, V113, P975, DOI 10.1016/j.foodchem.2008.08.047
   Bishop-Bailey D, 2000, BRIT J PHARMACOL, V129, P823, DOI 10.1038/sj.bjp.0703149
   Biswas P, 1998, BLOOD, V91, P258, DOI 10.1182/blood.V91.1.258.258_258_265
   Bnouham M, 2003, FITOTERAPIA, V74, P677, DOI 10.1016/S0367-326X(03)00182-5
   Brunner H, 2005, J HYPERTENS, V23, P233, DOI 10.1097/00004872-200502000-00001
   Butterfield DA, 2001, MECH AGEING DEV, V122, P945, DOI 10.1016/S0047-6374(01)00249-4
   Campana PRV, 2009, PHYTOMEDICINE, V16, P456, DOI 10.1016/j.phymed.2008.09.007
   Chang WH, 2010, J APPL PHYSIOL, V109, P1710, DOI 10.1152/japplphysiol.00205.2010
   Chen CM, 2005, WORLD J GASTROENTERO, V11, P5777, DOI 10.3748/wjg.v11.i37.5777
   Chen PN, 2006, CANCER LETT, V235, P248, DOI 10.1016/j.canlet.2005.04.033
   Chew YL, 2011, BMC COMPLEM ALTERN M, V11, DOI 10.1186/1472-6882-11-12
   Choi UK, 2010, INT J MOL SCI, V11, P67, DOI 10.3390/ijms11010067
   Chu YH, 2000, J SCI FOOD AGR, V80, P561, DOI 10.1002/(SICI)1097-0010(200004)80:5<561::AID-JSFA574>3.0.CO;2-#
   COCHRAN FR, 1992, IMMUNOPHARMACOLOGY, V23, P97, DOI 10.1016/0162-3109(92)90033-9
   Countryman AJ, 2013, ANN BEHAV MED, V45, P121, DOI 10.1007/s12160-012-9428-8
   Cumaoglu A, 2011, REJUV RES, V14, P325, DOI 10.1089/rej.2010.1111
   Deanfield J, 2005, J HYPERTENS, V23, P7, DOI 10.1097/00004872-200501000-00004
   DEGRAAF JC, 1992, CIRCULATION, V85, P2284, DOI 10.1161/01.CIR.85.6.2284
   Diamond BJ, 2000, ARCH PHYS MED REHAB, V81, P668, DOI 10.1053/mr.2000.3840
   Drager Luciano F, 2009, J Cardiometab Syndr, V4, P89, DOI 10.1111/j.1559-4572.2008.00046.x
   El Haouari M, 2006, PHYTOTHER RES, V20, P568, DOI 10.1002/ptr.1906
   Erdman JW, 2007, J NUTR, V137, p718S, DOI 10.1093/jn/137.3.718S
   González-Gallego J, 2010, BRIT J NUTR, V104, pS15, DOI 10.1017/S0007114510003910
   Gow AJ, 1996, FEBS LETT, V385, P63, DOI 10.1016/0014-5793(96)00347-X
   Gul MZ, 2011, BMC COMPLEM ALTERN M, V11, DOI 10.1186/1472-6882-11-64
   Gülçin I, 2004, J ETHNOPHARMACOL, V90, P205, DOI 10.1016/j.jep.2003.09.028
   Gupta SK, 2004, MOL CELL BIOCHEM, V260, P39
   Gyamfi MA, 1999, GEN PHARMACOL, V32, P661, DOI 10.1016/S0306-3623(98)00238-9
   Harizi H, 2011, CELL IMMUNOL, V267, P94, DOI 10.1016/j.cellimm.2010.12.002
   Hensley K, 2000, FREE RADICAL BIO MED, V28, P1456, DOI 10.1016/S0891-5849(00)00252-5
   Hiyasat B, 2009, PHARMACOLOGY, V83, P197, DOI 10.1159/000196811
   Huber SA, 1999, ARTERIOSCL THROM VAS, V19, P2364, DOI 10.1161/01.ATV.19.10.2364
   Hursting SD, 2012, ARTERIOSCL THROM VAS, V32, P1766, DOI 10.1161/ATVBAHA.111.241927
   Ischiropoulos H, 2003, BIOCHEM BIOPH RES CO, V305, P776, DOI 10.1016/S0006-291X(03)00814-3
   Isobe Y, 2012, FRONT IMMUNOL, V3, DOI 10.3389/fimmu.2012.00270
   Jeppesen J, 2001, ARCH INTERN MED, V161, P361, DOI 10.1001/archinte.161.3.361
   Jo EH, 2005, CANCER LETT, V230, P239, DOI 10.1016/j.canlet.2004.12.038
   Kähkönen MP, 1999, J AGR FOOD CHEM, V47, P3954, DOI 10.1021/jf990146l
   KAPLAN NM, 1989, ARCH INTERN MED, V149, P1514, DOI 10.1001/archinte.149.7.1514
   Kawakami K, 2010, BIOSCI BIOTECH BIOCH, V74, P1380, DOI 10.1271/bbb.100056
   Kedare SB, 2011, J FOOD SCI TECH MYS, V48, P412, DOI 10.1007/s13197-011-0251-1
   Keli SO, 1996, ARCH INTERN MED, V156, P637, DOI 10.1001/archinte.156.6.637
   Kim K, 2011, J NUTR BIOCHEM, V22, P964, DOI 10.1016/j.jnutbio.2010.08.008
   Kobayashi Y, 2010, BIOSCI BIOTECH BIOCH, V74, P2385, DOI 10.1271/bbb.100392
   Kolodziejczyk-Czepas J, 2013, PLATELETS, V24, P136, DOI 10.3109/09537104.2012.676221
   Konrad L, 2000, PLANTA MED, V66, P44, DOI 10.1055/s-2000-11117
   Kubica J, 2005, INT J MOL MED, V16, P173
   Kumagai T, 2004, J BIOL CHEM, V279, P48389, DOI 10.1074/jbc.M409935200
   Lahlou S, 2008, J ETHNOPHARMACOL, V120, P98, DOI 10.1016/j.jep.2008.07.041
   LeBars PL, 1997, JAMA-J AM MED ASSOC, V278, P1327, DOI 10.1001/jama.278.16.1327
   Lee JJ, 2012, J ATHEROSCLER THROMB, V19, P516, DOI 10.5551/jat.10058
   Lee YJ, 2011, AM J CHINESE MED, V39, P39, DOI 10.1142/S0192415X11008634
   Li XS, 2009, CHIN J INTEGR MED, V15, P26, DOI 10.1007/s11655-009-0026-8
   Libby P, 2001, CIRCULATION, V104, P365, DOI 10.1161/01.CIR.104.3.365
   LIBBY P, 1995, CIRCULATION, V91, P2844, DOI 10.1161/01.CIR.91.11.2844
   Lichius JJ, 1999, PLANTA MED, V65, P666, DOI 10.1055/s-2006-960844
   Manach C, 2005, AM J CLIN NUTR, V81, p230S, DOI 10.1093/ajcn/81.1.230S
   Manach C, 2004, AM J CLIN NUTR, V79, P727, DOI 10.1093/ajcn/79.5.727
   Marciniak Andrzej, 2003, Pol Arch Med Wewn, V109, P15
   MATKOVICS B, 1982, HORM METAB RES, V14, P77, DOI 10.1055/s-2007-1018928
   Michalska M, 2010, MED SCI MONITOR, V16, pRA110
   Middleton E, 1998, ADV EXP MED BIOL, V439, P175
   Mink PJ, 2007, AM J CLIN NUTR, V85, P895, DOI 10.1093/ajcn/85.3.895
   Mohanty IR, 2008, CLIN NUTR, V27, P635, DOI 10.1016/j.clnu.2008.05.006
   Mudnic I, 2009, PHYTOMEDICINE, V16, P462, DOI 10.1016/j.phymed.2008.11.004
   NABATA T, 1990, BIOCHEM INT, V20, P445
   Naik SR, 2007, LIVER INT, V27, P393, DOI 10.1111/j.1478-3231.2007.01463.x
   Nassiri-Asl Marjan, 2009, Zhong Xi Yi Jie He Xue Bao, V7, P428, DOI 10.3736/jcim20090506
   Neil HAW, 1996, J ROY COLL PHYS LOND, V30, P329
   Nöthlings U, 2008, J NUTR, V138, P775, DOI 10.1093/jn/138.4.775
   Oh H, 2002, PLANTA MED, V68, P932, DOI 10.1055/s-2002-34930
   Olas B, 2008, J PHYSIOL PHARMACOL, V59, P823
   Oliboni LS, 2011, AN ACAD BRAS CIENC, V83, P1403, DOI 10.1590/S0001-37652011000400027
   Osman AM, 2006, BIOCHEM BIOPH RES CO, V346, P321, DOI 10.1016/j.bbrc.2006.05.118
   Ou BX, 2002, J AGR FOOD CHEM, V50, P3122, DOI 10.1021/jf0116606
   Ou HC, 2009, J APPL PHYSIOL, V106, P1674, DOI 10.1152/japplphysiol.91415.2008
   PAPPOLLA MA, 1992, AM J PATHOL, V140, P621
   Paterniti I, 2009, N-S ARCH PHARMACOL, V380, P179, DOI 10.1007/s00210-009-0414-z
   Pedroso Daiana Cristina Chielli, 2012, Rev. Bras. Ginecol. Obstet., V34, P357, DOI 10.1590/S0100-72032012000800003
   Pirvulescu MM, 2011, PHYTOTHER RES, V25, P1737, DOI 10.1002/ptr.3463
   Poudyal H, 2010, J NUTR, V140, P946, DOI 10.3945/jn.109.117812
   RADOMSKI MW, 1987, LANCET, V2, P1057, DOI 10.1016/S0140-6736(87)91481-4
   Rattmann YD, 2012, J VASC RES, V49, P284, DOI 10.1159/000336647
   Renard CMGC, 2007, PHYTOCHEMISTRY, V68, P1128, DOI 10.1016/j.phytochem.2007.02.012
   Riehemann K, 1999, FEBS LETT, V442, P89, DOI 10.1016/S0014-5793(98)01622-6
   Ross R, 1999, AM HEART J, V138, pS419, DOI 10.1016/S0002-8703(99)70266-8
   Ryou SH, 2012, NUTR RES PRACT, V6, P106, DOI 10.4162/nrp.2012.6.2.106
   Sabitha V, 2011, J PHARM BIOALLIED SC, V3, P397, DOI 10.4103/0975-7406.84447
   Samanidou V, 2012, J SEP SCI, V35, P608, DOI 10.1002/jssc.201100894
   Shahriyary L, 2007, J ETHNOPHARMACOL, V114, P194, DOI 10.1016/j.jep.2007.07.029
   Shanmuganayagam D, 2012, J AGR FOOD CHEM, V60, P5787, DOI 10.1021/jf203487g
   Sies H, 1997, EXP PHYSIOL, V82, P291, DOI 10.1113/expphysiol.1997.sp004024
   Simandan T, 1998, BIOCHEM J, V335, P233, DOI 10.1042/bj3350233
   Singh I, 2008, NUTR METAB CARDIOVAS, V18, P127, DOI 10.1016/j.numecd.2006.09.001
   Skotnicka M, 2011, CENT EUR J IMMUNOL, V36, P284
   Soong YY, 2004, FOOD CHEM, V88, P411, DOI 10.1016/j.foodchem.2004.02.003
   Stadtman ER, 2000, ANN NY ACAD SCI, V899, P191
   Sudjana AN, 2009, INT J ANTIMICROB AG, V33, P461, DOI 10.1016/j.ijantimicag.2008.10.026
   Sukovich DA, 1998, ARTERIOSCL THROM VAS, V18, P1498, DOI 10.1161/01.ATV.18.9.1498
   Sun K, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047791
   Tabart J, 2006, J AGR FOOD CHEM, V54, P6271, DOI 10.1021/jf061112y
   Tahri A, 2000, J ETHNOPHARMACOL, V73, P95, DOI 10.1016/S0378-8741(00)00270-1
   Tanaka H, 2006, KIDNEY INT, V69, P369, DOI 10.1038/sj.ki.5000050
   Tanaka H, 2002, LETT APPL MICROBIOL, V35, P494, DOI 10.1046/j.1472-765X.2002.01222.x
   Tsumbu CN, 2012, INT J MOL SCI, V13, P628, DOI 10.3390/ijms13010628
   Tsumbu CN, 2011, NUTRIENTS, V3, P818, DOI 10.3390/nu3090818
   Tunali-Akbay T, 2007, PHYTOTHER RES, V21, P26, DOI 10.1002/ptr.2007
   Turek IA, 2012, KARDIOL POL, V70, P848
   Türkez H, 2011, J TOXICOL SCI, V36, P531
   Unachukwu UJ, 2010, J FOOD SCI, V75, pC541, DOI 10.1111/j.1750-3841.2010.01705.x
   Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
   VANDERWAL AC, 1989, LAB INVEST, V61, P166
   Varilek GW, 2001, J NUTR, V131, P2034, DOI 10.1093/jn/131.7.2034
   Vegas-Valle JM, 2012, REV ESP CARDIOL, V65, P108, DOI [10.1016/j.rec.2011.07.005, 10.1016/j.recesp.2011.07.006]
   Velioglu YS, 1998, J AGR FOOD CHEM, V46, P4113, DOI 10.1021/jf9801973
   Wahyudi Sianne, 2007, Acta Med Indones, V39, P66
   Xue WL, 2007, ASIA PAC J CLIN NUTR, V16, P422
   Wang SY, 2000, J AGR FOOD CHEM, V48, P140, DOI 10.1021/jf9908345
   Wang X, 2013, UROL INT, V90, P10, DOI 10.1159/000342804
   Williams CA, 1996, PHYTOCHEMISTRY, V42, P121, DOI 10.1016/0031-9422(95)00865-9
   Yasui K, 2012, BIOMED RES-TOKYO, V33, P9, DOI 10.2220/biomedres.33.9
   Yuan JQ, 2012, CHINESE MED J-PEKING, V125, P3725, DOI 10.3760/cma.j.issn.0366-6999.2012.20.023
   Zhang L, 2002, ACTA PHARMACOL SIN, V23, P919
   Ziyyat A, 1997, J ETHNOPHARMACOL, V58, P45, DOI 10.1016/S0378-8741(97)00077-9
   Zubelewicz-Szkodzinska Barbara, 2003, Kardiol Pol, V59, P465
NR 142
TC 11
Z9 12
U1 0
U2 12
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA 2, POZNAN, 61-615, POLAND
SN 1734-1922
EI 1896-9151
J9 ARCH MED SCI
JI Arch. Med. Sci.
PY 2015
VL 11
IS 4
BP 819
EP 839
DI 10.5114/aoms.2015.53303
PG 21
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CO9HG
UT WOS:000359484900016
PM 26322095
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Stahl, EP
   Dhindsa, DS
   Lee, SK
   Sandesara, PB
   Chalasani, NP
   Sperling, LS
AF Stahl, Eric P.
   Dhindsa, Devinder S.
   Lee, Suegene K.
   Sandesara, Pratik B.
   Chalasani, Naga P.
   Sperling, Laurence S.
TI Nonalcoholic Fatty Liver Disease and the Heart JACC
   State-of-the-Art Review
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Review
DE cardiovascular disease; metabolic syndrome; nonalcoholic fatty liver
   disease
ID GAMMA-GLUTAMYL-TRANSFERASE; 3RD NATIONAL-HEALTH; CARDIOVASCULAR-DISEASE;
   HEPATIC STEATOSIS; VITAMIN-E; BARIATRIC SURGERY; WEIGHT-LOSS; ALANINE
   AMINOTRANSFERASE; ENDOTHELIAL DYSFUNCTION; INCREASED PREVALENCE
AB Nonalcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD) are both manifestations of end-organ damage of the metabolic syndrome. Through multiple pathophysiological mechanisms, CVD and NAFLD are associated with each other. Systemic inflammation, endothelial dysfunction, hepatic insulin resistance, oxidative stress, and altered lipid metabolismare some of the mechanisms by which NAFLD increases the risk of CVD. Patients with NAFLD develop increased atherosclerosis, cardiomyopathy, and arrhythmia, which clinically result in cardiovascular morbidity and mortality. Defining the mechanisms linking these 2 diseases offers the opportunity to further develop targeted therapies. The aim of this comprehensive review is to examine the association between CVD and NAFLD and discuss the overlapping management approaches.
RP Sperling, LS (corresponding author), Emory Univ, Sch Med, Emory Heart Dis Prevent Ctr, 1365 Clifton Rd NE,Bldg A,Suite 2200, Atlanta, GA 30322 USA.
EM lsperli@emory.edu
CR Abu-Shanab A, 2010, NAT REV GASTRO HEPAT, V7, P691, DOI 10.1038/nrgastro.2010.172
   Adams LA, 2005, GASTROENTEROLOGY, V129, P113, DOI 10.1053/j.gastro.2005.04.014
   Adams LA, 2017, GUT, V66, P1138, DOI 10.1136/gutjnl-2017-313884
   Allen AM, 2018, HEPATOLOGY, V67, P1726, DOI 10.1002/hep.29546
   [Anonymous], CLIN GASTROENTEROL H
   [Anonymous], CLIN GASTROENTEROL H
   [Anonymous], J CLIN LIPIDOL
   [Anonymous], GASTROENTEROLOGY
   [Anonymous], 2019, Am Coll Cardiol
   Anstee QM, 2018, NAT REV GASTRO HEPAT, V15, P425, DOI 10.1038/s41575-018-0010-0
   Anstee QM, 2013, NAT REV GASTRO HEPAT, V10, P330, DOI 10.1038/nrgastro.2013.41
   Armstrong MJ, 2016, LANCET, V387, P679, DOI 10.1016/S0140-6736(15)00803-X
   Athyros VG, 2010, LANCET, V376, P1916, DOI 10.1016/S0140-6736(10)61272-X
   Athyros VG, 2011, ARCH MED SCI, V7, P796, DOI 10.5114/aoms.2011.25554
   Bader T, 2010, AM J GASTROENTEROL, V105, P978, DOI 10.1038/ajg.2010.102
   Bays H, 2014, J CLIN LIPIDOL, V8, pS47, DOI 10.1016/j.jacl.2014.02.011
   Belfort R, 2006, NEW ENGL J MED, V355, P2297, DOI 10.1056/NEJMoa060326
   Birkenfeld AL, 2014, HEPATOLOGY, V59, P713, DOI 10.1002/hep.26672
   Björnsson E, 2012, J HEPATOL, V56, P374, DOI [10.1016/j.jhep.2011.08.016, 10.1016/j.jhep.2011.07.023]
   Bonapace S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0088371
   Bower G, 2015, OBES SURG, V25, P2280, DOI 10.1007/s11695-015-1691-x
   Brown JM, 2015, ANNU REV MED, V66, P343, DOI 10.1146/annurev-med-060513-093205
   Browning JD, 2004, HEPATOLOGY, V40, P1387, DOI 10.1002/hep.20466
   Catapano AL, 2016, EUR HEART J, V37, P2999, DOI 10.1093/eurheartj/ehw272
   Chalasani N, 2005, HEPATOLOGY, V41, P690, DOI 10.1002/hep.20671
   Chalasani N, 2004, GASTROENTEROLOGY, V126, P1287, DOI 10.1053/j.gastro.2004.02.015
   Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI 10.1002/hep.29367
   Chang Y, 2019, HEPATOLOGY, V69, P64, DOI 10.1002/hep.30170
   Cohen DE, 2006, AM J CARDIOL, V97, p77C, DOI 10.1016/j.amjcard.2005.12.014
   Collins R, 2002, LANCET, V360, P7, DOI 10.1016/S0140-6736(02)09327-3
   Corey KE, 2016, DIGEST DIS SCI, V61, P2108, DOI 10.1007/s10620-016-4044-2
   Corey KE, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-100
   Costanzo S, 2010, J AM COLL CARDIOL, V55, P1339, DOI 10.1016/j.jacc.2010.01.006
   Coulon S, 2012, CYTOKINE, V59, P442, DOI 10.1016/j.cyto.2012.05.001
   Cusi K, 2016, ANN INTERN MED, V165, P305, DOI 10.7326/M15-1774
   Cusi K, 2012, GASTROENTEROLOGY, V142, P711, DOI 10.1053/j.gastro.2012.02.003
   Deanfield JE, 2007, CIRCULATION, V115, P1285, DOI 10.1161/CIRCULATIONAHA.106.652859
   DeFilippis AP, 2013, ATHEROSCLEROSIS, V227, P429, DOI 10.1016/j.atherosclerosis.2013.01.022
   Del Ben M, 2017, NUTR METAB CARDIOVAS, V27, P161, DOI 10.1016/j.numecd.2016.09.011
   Dogan S, 2015, EUR J GASTROEN HEPAT, V27, P298, DOI 10.1097/MEG.0000000000000286
   Dongiovanni P, 2015, HEPATOLOGY, V61, P506, DOI 10.1002/hep.27490
   Dormandy JA, 2005, LANCET, V366, P1279, DOI 10.1016/S0140-6736(05)67528-9
   Dormandy J, 2009, DRUG SAFETY, V32, P187, DOI 10.2165/00002018-200932030-00002
   Downs JR, 1998, JAMA-J AM MED ASSOC, V279, P1615, DOI 10.1001/jama.279.20.1615
   Dunn W, 2008, AM J GASTROENTEROL, V103, P2263, DOI 10.1111/j.1572-0241.2008.02034.x
   EASL, 2016, OBESITY FACTS, V9, P65, DOI [10.1159/000443344, 10.1007/s00125-016-3902-y, 10.1016/j.jhep.2015.11.004]
   Ekstedt M, 2015, HEPATOLOGY, V61, P1547, DOI 10.1002/hep.27368
   Emre A, 2015, AM J CARDIOL, V116, P1810, DOI 10.1016/j.amjcard.2015.09.021
   Erdmann E, 2007, J AM COLL CARDIOL, V49, P1772, DOI 10.1016/j.jacc.2006.12.048
   Fracanzani AL, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0162473
   Francque S, 2012, LAB INVEST, V92, P1428, DOI 10.1038/labinvest.2012.103
   Francque SM, 2016, J HEPATOL, V65, P425, DOI 10.1016/j.jhep.2016.04.005
   Fraser A, 2007, ARTERIOSCL THROM VAS, V27, P2729, DOI 10.1161/ATVBAHA.107.152298
   Fraser A, 2009, DIABETES CARE, V32, P741, DOI 10.2337/dc08-1870
   Friedman SL, 2018, HEPATOLOGY, V67, P1754, DOI 10.1002/hep.29477
   Georgescu EF, 2009, WORLD J GASTROENTERO, V15, P942, DOI 10.3748/wjg.15.942
   Gill RM, 2011, AM J SURG PATHOL, V35, P1400, DOI 10.1097/PAS.0b013e3182254283
   Guo KF, 2017, J DIABETES COMPLICAT, V31, P80, DOI 10.1016/j.jdiacomp.2016.09.008
   Haddad TM, 2017, DIAB MET SYND CLIN R, V11, pS209, DOI 10.1016/j.dsx.2016.12.033
   Hallsworth K, 2013, J HEPATOL, V58, P757, DOI 10.1016/j.jhep.2012.11.015
   Hamaguchi M, 2007, WORLD J GASTROENTERO, V13, P1579, DOI 10.3748/wjg.v13.i10.1579
   Hameed B, 2018, ALIMENT PHARM THER, V47, P645, DOI 10.1111/apt.14492
   Haring R, 2009, HEPATOLOGY, V50, P1403, DOI 10.1002/hep.23135
   Hung CS, 2015, J AM HEART ASSOC, V4, DOI 10.1161/JAHA.115.001820
   Hyogo H, 2011, HEPATOL RES, V41, P1057, DOI 10.1111/j.1872-034X.2011.00849.x
   Ishiba H, 2016, HEPATOL RES, V46, P1107, DOI 10.1111/hepr.12665
   Jaruvongvanich V, 2016, DIGEST LIVER DIS, V48, P1410, DOI 10.1016/j.dld.2016.09.002
   Kang Ji Hoon, 2012, J Cardiovasc Ultrasound, V20, P126, DOI 10.4250/jcu.2012.20.3.126
   Käräjämäki AJ, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0142937
   Kargiotis K, 2015, WORLD J GASTROENTERO, V21, P7860, DOI 10.3748/wjg.v21.i25.7860
   Kashani A, 2006, CIRCULATION, V114, P2788, DOI 10.1161/CIRCULATIONAHA.106.624890
   Kasumov T, 2011, METABOLISM, V60, P776, DOI 10.1016/j.metabol.2010.07.027
   Kaswala DH, 2016, DIGEST DIS SCI, V61, P1356, DOI 10.1007/s10620-016-4079-4
   Keskin M, 2017, AM J CARDIOL, V120, P1720, DOI 10.1016/j.amjcard.2017.07.107
   Kim D, 2013, HEPATOLOGY, V57, P1357, DOI 10.1002/hep.26156
   Kim D, 2012, HEPATOLOGY, V56, P605, DOI 10.1002/hep.25593
   Kim J, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0180118
   Kotronen A, 2008, ARTERIOSCL THROM VAS, V28, P27, DOI 10.1161/ATVBAHA.107.147538
   Kozlitina J, 2014, NAT GENET, V46, P352, DOI 10.1038/ng.2901
   Kumar MS, 2016, INT J HEPATOL, V2016, DOI 10.1155/2016/5160754
   Lassailly G, 2015, GASTROENTEROLOGY, V149, P379, DOI 10.1053/j.gastro.2015.04.014
   Lauridsen BK, 2018, EUR HEART J, V39, P385, DOI 10.1093/eurheartj/ehx662
   Lavine JE, 2011, JAMA-J AM MED ASSOC, V305, P1659, DOI 10.1001/jama.2011.520
   Lazo M, 2013, AM J EPIDEMIOL, V178, P38, DOI 10.1093/aje/kws448
   Lazo M, 2011, BMJ-BRIT MED J, V343, DOI 10.1136/bmj.d6891
   Le MH, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0173499
   Leamy AK, 2013, PROG LIPID RES, V52, P165, DOI 10.1016/j.plipres.2012.10.004
   Liao HW, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2016-013927
   Lim S, 2015, INT J CARDIOL, V201, P408, DOI 10.1016/j.ijcard.2015.08.107
   Lonardo A, 2018, J HEPATOL, V68, P335, DOI 10.1016/j.jhep.2017.09.021
   Lonardo A, 2016, METABOLISM, V65, P1136, DOI 10.1016/j.metabol.2015.09.017
   Long MT, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.116.005227
   Lonn E, 2005, JAMA-J AM MED ASSOC, V293, P1338, DOI 10.1001/jama.293.11.1338
   Ma JT, 2017, J HEPATOL, V66, P390, DOI 10.1016/j.jhep.2016.09.022
   Männistö VT, 2014, J LIPID RES, V55, P2676, DOI 10.1194/jlr.P054387
   Mantovani A, 2018, DIABETES CARE, V41, P372, DOI 10.2337/dc17-1902
   Mantovani A, 2017, J CLIN TRANSL HEPATO, V5, P134, DOI 10.14218/JCTH.2017.00005
   Mantovani A, 2016, DIABETES CARE, V39, P1416, DOI 10.2337/dc16-0091
   Mantovani A, 2015, METABOLISM, V64, P879, DOI 10.1016/j.metabol.2015.04.003
   Markus MRP, 2013, ARTERIOSCL THROM VAS, V33, P1690, DOI 10.1161/ATVBAHA.112.300556
   Marso SP, 2016, NEW ENGL J MED, V375, P311, DOI 10.1056/NEJMoa1603827
   Masuoka HC, 2013, ANN NY ACAD SCI, V1281, P106, DOI 10.1111/nyas.12016
   Matteoni CA, 1999, GASTROENTEROLOGY, V116, P1413, DOI 10.1016/S0016-5085(99)70506-8
   MEYTHALER JM, 1987, ARCH INTERN MED, V147, P61
   Musso G, 2017, JAMA INTERN MED, V177, P633, DOI 10.1001/jamainternmed.2016.9607
   Nascimbeni F, 2016, BMJ OPEN GASTROENTER, V3, DOI 10.1136/bmjgast-2015-000075
   Neuschwander-Tetri BA, 2015, LANCET, V385, P956, DOI 10.1016/S0140-6736(14)61933-4
   Neuschwander-Tetri BA, 2010, HEPATOLOGY, V52, P774, DOI 10.1002/hep.23719
   Ong JP, 2008, J HEPATOL, V49, P608, DOI 10.1016/j.jhep.2008.06.018
   Oni ET, 2015, AM J CARDIOL, V115, P34, DOI 10.1016/j.amjcard.2014.09.044
   Pacana T, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0136822
   Palmer CNA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039362
   Pappachan JM, 2014, ENDOCRINE, V45, P344, DOI 10.1007/s12020-013-0087-8
   Pareek M, 2018, J AM COLL CARDIOL, V71, P670, DOI 10.1016/j.jacc.2017.12.014
   Park HE, 2016, J CLIN ENDOCR METAB, V101, P3134, DOI 10.1210/jc.2016-1525
   PEDERSEN TR, 1994, LANCET, V344, P1383
   Petta S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0074089
   Pickhardt PJ, 2014, AM J ROENTGENOL, V202, P752, DOI 10.2214/AJR.13.11367
   Pisto P, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2014-004973
   Puchner SB, 2015, RADIOLOGY, V274, P693, DOI 10.1148/radiol.14140933
   Ratziu V, 2018, J HEPATOL, V68, pS1, DOI 10.1016/S0168-8278(18)30221-6
   Ratziu V, 2016, GASTROENTEROLOGY, V150, P1147, DOI 10.1053/j.gastro.2016.01.038
   Riley P, 2009, CARDIOVASC THER, V27, P216, DOI 10.1111/j.1755-5922.2009.00088.x
   Rouabhia S, 2014, EXPERT REV GASTROENT, V8, P343, DOI 10.1586/17474124.2014.894880
   Said A, 2017, ANN HEPATOL, V16, P538, DOI 10.5604/01.3001.0010.0284
   Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929
   Sesso HD, 2008, JAMA-J AM MED ASSOC, V300, P2123, DOI 10.1001/jama.2008.600
   Shen H, 2014, ALIMENT PHARM THER, V40, P1066, DOI 10.1111/apt.12944
   Sinn DH, 2017, GUT, V66, P323, DOI 10.1136/gutjnl-2016-311854
   Sinn DH, 2016, GASTROENTEROLOGY, V151, P481, DOI 10.1053/j.gastro.2016.06.001
   Sinner MF, 2013, AM J CARDIOL, V111, P219, DOI 10.1016/j.amjcard.2012.09.021
   Smagris E, 2015, HEPATOLOGY, V61, P108, DOI 10.1002/hep.27242
   Söderberg C, 2010, HEPATOLOGY, V51, P595, DOI 10.1002/hep.23314
   Sonmez A, 2015, J CLIN LIPIDOL, V9, P576, DOI 10.1016/j.jacl.2015.03.010
   Sookoian S, 2008, J HEPATOL, V49, P600, DOI 10.1016/j.jhep.2008.06.012
   Sperling LS, 2015, J AM COLL CARDIOL, V66, P1050, DOI 10.1016/j.jacc.2015.06.1328
   Stone NJ, 2014, J AM COLL CARDIOL, V63, P2889, DOI 10.1016/j.jacc.2013.11.002
   Sumida Y, 2018, J GASTROENTEROL, V53, P362, DOI 10.1007/s00535-017-1415-1
   Sung KC, 2012, DIABETES CARE, V35, P2359, DOI 10.2337/dc12-0515
   Targher G, 2006, DIABETIC MED, V23, P403, DOI 10.1111/j.1464-5491.2006.01817.x
   Targher G, 2007, DIABETES CARE, V30, P2119, DOI 10.2337/dc07-0349
   Targher G, 2007, DIABETES CARE, V30, P1212, DOI 10.2337/dc06-2247
   Targher G, 2016, J HEPATOL, V65, P589, DOI 10.1016/j.jhep.2016.05.013
   Targher G, 2013, CLIN SCI, V125, P301, DOI 10.1042/CS20130036
   Targher G, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057183
   Targher G, 2010, NEW ENGL J MED, V363, P1341, DOI 10.1056/NEJMra0912063
   Tikkanen MJ, 2013, INT J CARDIOL, V168, P3846, DOI 10.1016/j.ijcard.2013.06.024
   Treeprasertsuk S, 2012, LIVER INT, V32, P945, DOI 10.1111/j.1478-3231.2011.02753.x
   Tripodi A, 2014, J HEPATOL, V61, P148, DOI 10.1016/j.jhep.2014.03.013
   Trovato FM, 2016, INT J CARDIOL, V221, P275, DOI 10.1016/j.ijcard.2016.06.180
   VanWagner LB, 2015, HEPATOLOGY, V62, P773, DOI 10.1002/hep.27869
   Vest AR, 2012, HEART, V98, P1763, DOI 10.1136/heartjnl-2012-301778
   Vilar-Gomez E, 2015, GASTROENTEROLOGY, V149, P367, DOI 10.1053/j.gastro.2015.04.005
   Villanova N, 2005, HEPATOLOGY, V42, P473, DOI 10.1002/hep.20781
   Vorsanger MH, 2016, J AM COLL CARDIOL, V68, P849, DOI 10.1016/j.jacc.2016.06.007
   Wong RJ, 2015, GASTROENTEROLOGY, V148, P547, DOI 10.1053/j.gastro.2014.11.039
   Wong VWS, 2016, HEPATOLOGY, V63, P754, DOI 10.1002/hep.28253
   Wu RN, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-09851-5
   Wu SQ, 2016, SCI REP-UK, V6, DOI 10.1038/srep33386
   Yilmaz Y, 2011, ARCH MED RES, V42, P38, DOI 10.1016/j.arcmed.2010.12.001
   Ylä-Herttuala S, 2007, J AM COLL CARDIOL, V49, P1015, DOI 10.1016/j.jacc.2006.09.053
   Yokohama S, 2004, HEPATOLOGY, V40, P1222, DOI 10.1002/hep.20420
   Younossi Z, 2018, NAT REV GASTRO HEPAT, V15, P11, DOI 10.1038/nrgastro.2017.109
   Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431
   Yusuf S, 2000, NEW ENGL J MED, V342, P154, DOI 10.1056/NEJM200001203420302
   Zeb I, 2016, J AM COLL CARDIOL, V67, P1965, DOI 10.1016/j.jacc.2016.01.070
   Zhou YY, 2018, HEPATOL COMMUN, V2, P376, DOI 10.1002/hep4.1155
   Zhou YJ, 2012, J DIGEST DIS, V13, P153, DOI 10.1111/j.1751-2980.2011.00571.x
NR 168
TC 295
Z9 305
U1 3
U2 28
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD MAR 5
PY 2019
VL 73
IS 8
BP 949
EP 963
PG 15
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA HN0IV
UT WOS:000459872000012
PM 30819364
HC Y
HP N
DA 2025-06-11
ER

PT J
AU da Silva, FC
   Hernandez, SSS
   Gonçalves, E
   Arancibia, BAV
   Castro, TLD
   Da Silva, R
AF da Silva, Franciele Cascaes
   Soleman Hernandez, Salma Stephany
   Goncalves, Elizandra
   Valdivia Arancibia, Beatriz Angelica
   Da Silva Castro, Thiago Luis
   Da Silva, Rudney
TI Anthropometric indicators of obesity in policemen: A systematic review
   of observational studies
SO INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH
LA English
DT Review
DE Obesity; Police; Systematic review; Observational study
ID HEART-DISEASE RISK; LONG WORK HOURS; METABOLIC SYNDROME; OXIDATIVE
   STRESS; PHYSICAL-ACTIVITY; OFFICERS; ADIPOSITY; FITNESS; COHORT; IMPACT
AB The aim of this paper was to summarize scientific literature on obesity in policemen through a systematic review of observational studies. For this purpose the following electronic databases were selected: Medline by Pubmed, CINAHL, and Scopus; and a manual search of the referenced studies concerning this topic was performed. There were no restrictions with respect to the year or language of the publication. Twenty-three studies were identified and 9 articles, considered as potentially relevant, were included. The labor time, shift and career progression promoted changes in body composition. Most of the policemen taking part in the studies included in this paper were overweight (BMI: 25.2-29.3), obese (body fat a parts per thousand yen 25%), had increased waist (90.4-102 cm) and abdominal perimeters (18.9-90.5 cm), and had a higher risk of chronic disease, which is associated with depression and stress development. Interventional studies are needed for the purpose of proposing preventive and rehabilitation programs, which would result in providing physical and mental well-being, improvement of life quality and, especially, prevention of obesity related to police work.
C1 [da Silva, Franciele Cascaes; Soleman Hernandez, Salma Stephany; Goncalves, Elizandra; Valdivia Arancibia, Beatriz Angelica; Da Silva Castro, Thiago Luis; Da Silva, Rudney] Univ Estado Santa Catarina, Ctr Hlth Sci & Sports, Adapted Phys Act Lab, BR-88080350 Florianopolis, SC, Brazil.
C3 Universidade do Estado de Santa Catarina
RP da Silva, FC (corresponding author), Univ Estado Santa Catarina, Ctr Hlth Sci & Sports, Adapted Phys Act Lab, Pascoal Simone St 358, BR-88080350 Florianopolis, SC, Brazil.
EM francascaes@yahoo.com.br
RI Silva, Rudney/C-3189-2017
OI Silva, Rudney/0000-0002-9386-0039
FU Foundation for Research and Innovation in the State of Santa Catarina
   (FAPESC) [13.680/2011-8]
FX Foundation for Research and Innovation in the State of Santa Catarina
   (FAPESC) under protocol 13.680/2011-8.
CR Abelson P, 2004, SCIENCE, V304, P1413, DOI 10.1126/science.304.5676.1413
   Alasagheirin MH, 2011, AAOHN J, V59, P469, DOI 10.3928/08910162-20111017-01
   [Anonymous], 2010, REV BRAS MED TRAB
   [Anonymous], COCHRANE HDB SYSTEMA
   [Anonymous], KUOPIO U PUBLICATION
   [Anonymous], J ENV PUBLIC HLTH
   [Anonymous], OBESITY LANCET
   [Anonymous], 2017, The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses
   Barbosa R.O., 2013, Rev Bras Cardiol, V26, P45
   Boyce RW., 2008, Journal of Exercise Physiology Online, V11, P1
   Braga RT, 2014, AM J MENS HEALTH, V8, P503, DOI 10.1177/1557988314526750
   Charles LE, 2008, OBESITY, V16, P2489, DOI 10.1038/oby.2008.395
   Dennis KE, 2007, JOGNN-J OBST GYN NEO, V36, P511, DOI [10.1111/j.1552-6909.2007.00180.x, 10.1111/J.1552-6909.2007.00180.x]
   Donadussi C, 2009, REV NUTR, V22, P847, DOI 10.1590/S1415-52732009000600006
   Franke WD, 1997, AM J IND MED, V31, P733
   Franke WD, 2002, J OCCUP ENVIRON MED, V44, P1182, DOI 10.1097/00043764-200212000-00014
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gu JK, 2012, J OCCUP ENVIRON MED, V54, P1374, DOI 10.1097/JOM.0b013e31825f2bea
   Harvey SB, 2010, OCCUP MED-OXFORD, V60, P362, DOI 10.1093/occmed/kqq031
   McCanlies EC, 2012, WORK, V43, P133, DOI 10.3233/WOR-2012-1399
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Pyörälä M, 1998, CIRCULATION, V98, P398, DOI 10.1161/01.CIR.98.5.398
   Ramey Sandra L, 2004, AAOHN J, V52, P116
   Santana AMC, 2012, WORK, V41, P2908, DOI 10.3233/WOR-2012-0543-2908
   Sarmento RA, 2013, ARQ BRAS CARDIOL, V101, P240
   Sassen B, 2009, EUR J CARDIOV PREV R, V16, P677, DOI 10.1097/HJR.0b013e3283312e94
   Simon GE, 2006, ARCH GEN PSYCHIAT, V63, P824, DOI 10.1001/archpsyc.63.7.824
   Sörensen L, 2000, OCCUP MED-OXFORD, V50, P3, DOI 10.1093/occmed/50.1.3
   Spitler D L, 1987, Br J Sports Med, V21, P154
   STAMFORD BA, 1978, MED SCI SPORT EXER, V10, P294
   Thayyil J, 2012, N AM J MED SCI, V4, P630, DOI 10.4103/1947-2714.104313
   Vila B, 2006, AM J IND MED, V49, P972, DOI 10.1002/ajim.20333
   Vincent HK, 2007, DIABETES OBES METAB, V9, P813, DOI 10.1111/j.1463-1326.2007.00692.x
   Violanti JM, 2006, ANN EPIDEMIOL, V16, P148, DOI 10.1016/j.annepidem.2005.07.054
   Violanti JM, 1998, AM J IND MED, V33, P366, DOI 10.1002/(SICI)1097-0274(199804)33:4<366::AID-AJIM6>3.0.CO;2-S
   Violanti John M, 2011, Int J Emerg Ment Health, V13, P257
   Violanti JM, 2009, ARCH ENVIRON OCCUP H, V64, P194, DOI 10.1080/19338240903241259
NR 37
TC 19
Z9 22
U1 0
U2 16
PU NOFER INST OCCUPATIONAL MEDICINE, POLAND
PI LODZ
PA SW TERESY 8, LODZ, 91-348, POLAND
SN 1232-1087
EI 1896-494X
J9 INT J OCCUP MED ENV
JI Int. J. Occup. Med. Environ. Health
PD DEC
PY 2014
VL 27
IS 6
BP 891
EP 901
DI 10.2478/s13382-014-0318-0
PG 11
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA AY6ND
UT WOS:000347682000002
PM 25503888
OA gold
DA 2025-06-11
ER

PT J
AU Aprea, G
   Del Matto, I
   Tucci, P
   Marino, L
   Scattolini, S
   Rossi, F
AF Aprea, Giuseppe
   Del Matto, Ilaria
   Tucci, Patrizia
   Marino, Lucio
   Scattolini, Silvia
   Rossi, Franca
TI In Vivo Functional Properties of Dairy Bacteria
SO MICROORGANISMS
LA English
DT Review
DE dairy microorganisms; SLAB; NSLAB; propionibacteria; minor species; in
   vivo studies
ID ORIGINATED PROBIOTIC BACTERIUM; LACTOBACILLUS-CASEI ZHANG; INTESTINAL
   MICROBIOTA; INNER-MONGOLIA; CANCER-CELLS; PLANTARUM; CHEESE; VITRO;
   FREUDENREICHII; MECHANISMS
AB This literature review aimed to collect investigations on the in vivo evidence for bacteria associated with fermented dairy foods to behave as probiotics with beneficial effects in the prevention and treatment of various diseases. All main bacterial groups commonly present in high numbers in fermented milks or cheeses were taken into account, namely starter lactic acid bacteria (SLAB) Lactobacillus delbrueckii subsp. bulgaricus and lactis, L. helveticus, Lactococcus lactis, Streptococcus thermophilus, non-starter LAB (NSLAB) Lacticaseibacillus spp., Lactiplantibacillus plantarum, dairy propionibacteria, and other less frequently encountered species. Only studies regarding strains of proven dairy origin were considered. Studies in animal models and clinical studies showed that dairy bacteria ameliorate symptoms of inflammatory bowel disease (IBD), mucositis, metabolic syndrome, aging and oxidative stress, cancer, bone diseases, atopic dermatitis, allergies, infections and damage caused by pollutants, mild stress, and depression. Immunomodulation and changes in the intestinal microbiota were the mechanisms most often involved in the observed effects. The results of the studies considered indicated that milk and dairy products are a rich source of beneficial bacteria that should be further exploited to the advantage of human and animal health.
C1 [Aprea, Giuseppe; Del Matto, Ilaria; Tucci, Patrizia; Marino, Lucio; Scattolini, Silvia; Rossi, Franca] Ist Zooprofilatt Sperimentale Abruzzo & Molise G C, Campo Boario, I-64100 Teramo, Italy.
RP Rossi, F (corresponding author), Ist Zooprofilatt Sperimentale Abruzzo & Molise G C, Campo Boario, I-64100 Teramo, Italy.
EM g.aprea@izs.it; i.delmatto@izs.it; p.tucci@izs.it; l.marino@izs.it;
   s.scattolini@izs.it; f.rossi@izs.it
RI Del Matto, Ilaria/AAS-5512-2021; Scattolini, Silvia/A-6023-2016; Rossi,
   Franca/X-8036-2018; Tucci, Patrizia/J-2683-2016; Aprea,
   Giuseppe/C-1057-2017
OI Rossi, Franca/0000-0002-7443-1538; Del Matto,
   Ilaria/0000-0002-9805-3711; Tucci, Patrizia/0000-0002-7051-8505; Aprea,
   Giuseppe/0000-0003-4783-3432; Marino, Lucio/0000-0002-3002-1609
CR Acurcio LB, 2017, J FUNCT FOODS, V33, P436, DOI 10.1016/j.jff.2017.04.010
   Aindelis G, 2020, CANCERS, V12, DOI 10.3390/cancers12020368
   Al-Emran HM, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-24791-5
   Aljasir SF, 2021, FOOD RES INT, V149, DOI 10.1016/j.foodres.2021.110699
   Amadoro C, 2018, LWT-FOOD SCI TECHNOL, V93, P376, DOI 10.1016/j.lwt.2018.03.056
   An M, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-82282-5
   Anjana, 2022, FRONT CELL INFECT MI, V12, DOI 10.3389/fcimb.2022.851140
   Apostolakos I, 2022, APPL SCI-BASEL, V12, DOI 10.3390/app12199620
   Aprea G, 2021, APPL SCI-BASEL, V11, DOI 10.3390/app11177897
   Baccouri O, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.00881
   Baños A, 2019, FOOD MICROBIOL, V77, P69, DOI 10.1016/j.fm.2018.08.002
   Barreto LBE, 2022, CELL BIOL INT, V46, P701, DOI 10.1002/cbin.11764
   Beltrán-Barrientos LM, 2021, J DAIRY SCI, V104, P3779, DOI 10.3168/jds.2020-19466
   Bengoa AA, 2020, INT DAIRY J, V111, DOI 10.1016/j.idairyj.2020.104839
   Carucci L, 2022, PEDIAT ALLERG IMM-UK, V33, DOI 10.1111/pai.13836
   Chiasson JL, 2002, LANCET, V359, P2072, DOI 10.1016/S0140-6736(02)08905-5
   Chondrou P, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8050709
   Chong HX, 2019, BENEF MICROBES, V10, P355, DOI 10.3920/BM2018.0135
   Chong HX, 2019, J DAIRY SCI, V102, P4783, DOI 10.3168/jds.2018-16103
   Chouikhi A, 2022, ARCH MICROBIOL, V204, DOI 10.1007/s00203-021-02634-7
   Darwish AMG, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0263241
   Del Matto I, 2021, INT J DAIRY TECHNOL, V74, P564, DOI 10.1111/1471-0307.12787
   Desaka N, 2022, J CLIN BIOCHEM NUTR, V70, P7, DOI 10.3164/jcbn.21-56
   Domann E, 2007, INT J MED MICROBIOL, V297, P533, DOI 10.1016/j.ijmm.2007.02.008
   Evivie SE, 2020, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.583070
   Evivie SE, 2020, FOOD FUNCT, V11, P6573, DOI [10.1039/d0fo01218a, 10.1039/D0FO01218A]
   Evivie SE, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.00782
   Fayol-Messaoudi D, 2007, J APPL MICROBIOL, V103, P657, DOI 10.1111/j.1365-2672.2007.03293.x
   Feng PY, 2022, NPJ BIOFILMS MICROBI, V8, DOI 10.1038/s41522-022-00326-8
   Food and Agriculture Organization of the United Nations (FAO), Probiotics in Food: Health and Nutritional Properties and Guidelines for Evaluation
   Nia FF, 2023, WORLD J MICROB BIOT, V39, DOI 10.1007/s11274-023-03555-x
   Fu LL, 2020, MOL NUTR FOOD RES, V64, DOI 10.1002/mnfr.201900496
   Galland L, 2010, NUTR CLIN PRACT, V25, P634, DOI 10.1177/0884533610385703
   Gao K, 2022, BENEF MICROBES, V13, P473, DOI 10.3920/BM2022.0052
   Gao K, 2022, FOOD FUNCT, V13, P957, DOI [10.1039/D1FO03723D, 10.1039/d1fo03723d]
   Glazunova OA, 2022, NUTRIENTS, V14, DOI 10.3390/nu14245357
   Han F, 2020, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.598010
   Hill C, 2014, NAT REV GASTRO HEPAT, V11, P506, DOI 10.1038/nrgastro.2014.66
   Ho SW, 2022, J NUTR BIOCHEM, V99, DOI 10.1016/j.jnutbio.2021.108858
   Hor YY, 2019, PHARMACOL RES, V146, DOI 10.1016/j.phrs.2019.104312
   Hu JT, 2015, J BIOSCIENCES, V40, P269, DOI 10.1007/s12038-015-9518-4
   Huynh VA, 2023, FRONT CELL INFECT MI, V13, DOI 10.3389/fcimb.2023.1181315
   Illikoud N, 2022, IMMUNOL LETT, V251-252, P91, DOI 10.1016/j.imlet.2022.11.002
   Ishimwe N, 2015, MOL NUTR FOOD RES, V59, P94, DOI 10.1002/mnfr.201400548
   Ismael M, 2022, FOODS, V11, DOI 10.3390/foods11233766
   Jaskulski IB, 2020, PROCESS BIOCHEM, V91, P165, DOI 10.1016/j.procbio.2019.12.008
   Jeon MG, 2020, J MED FOOD, V23, P852, DOI 10.1089/jmf.2019.4636
   Jia R, 2022, COMPUT MATH METHOD M, V2022, DOI 10.1155/2022/4968016
   Jin SW, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8081175
   Kalam LA, 2023, J BIOSCI BIOENG, V135, P1, DOI 10.1016/j.jbiosc.2022.10.010
   Kang X, 2021, LETT APPL MICROBIOL, V72, P677, DOI 10.1111/lam.13398
   Karaffová V, 2021, MICROORGANISMS, V9, DOI 10.3390/microorganisms9040831
   Kim JH, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-36864-5
   Kobatake E, 2019, MICROBIOL IMMUNOL, V63, P293, DOI 10.1111/1348-0421.12719
   Kobayashi K, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122998
   Kwok LY, 2014, BENEF MICROBES, V5, P295, DOI 10.3920/BM2013.0047
   Kwon G, 2016, SCI REP-UK, V6, DOI 10.1038/srep31713
   Landry B.U., 2021, J. Adv. Biol. Biotechnol, P24, DOI [DOI 10.9734/JABB/2021/V24I230199, 10.9734/jabb/2021/v24i230199]
   Le Barz M, 2019, FASEB J, V33, P4921, DOI 10.1096/fj.201801672R
   Lester CH, 2006, ANTIMICROB AGENTS CH, V50, P596, DOI 10.1128/AAC.50.2.596-599.2006
   Li BL, 2019, FOOD FUNCT, V10, P1707, DOI 10.1039/c8fo01920g
   Li BL, 2018, FOOD FUNCT, V9, P6587, DOI 10.1039/c8fo01768a
   Li Q, 2021, GASTROENTEROLOGY, V160, P1179, DOI 10.1053/j.gastro.2020.09.003
   Li YJ, 2022, J FUNCT FOODS, V99, DOI 10.1016/j.jff.2022.105353
   Liu GX, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21134608
   Liu Mingzhen, 2022, Food Res Int, V157, P111283, DOI 10.1016/j.foodres.2022.111283
   Liu Y, 2021, MICROORGANISMS, V9, DOI 10.3390/microorganisms9102086
   Liu Y, 2021, CYTA-J FOOD, V19, P408, DOI 10.1080/19476337.2021.1914176
   Makino T, 2019, BIOSCI BIOTECH BIOCH, V83, P2298, DOI 10.1080/09168451.2019.1654847
   Makwana S, 2023, FOOD PROD PROCESS NU, V5, DOI 10.1186/s43014-022-00112-1
   Marco ML, 2021, NAT REV GASTRO HEPAT, V18, P196, DOI 10.1038/s41575-020-00390-5
   Martin-Gallausiaux C, 2021, P NUTR SOC, V80, P37, DOI 10.1017/S0029665120006916
   Mas-Bargues C, 2021, ARCH BIOCHEM BIOPHYS, V709, DOI 10.1016/j.abb.2021.108941
   Milani C, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-09303-w
   Nair DVT, 2021, POULTRY SCI, V100, P283, DOI 10.1016/j.psj.2020.09.091
   Nair DVT, 2019, J APPL POULTRY RES, V28, P356, DOI 10.3382/japr/pfy079
   Nami Y, 2019, LWT-FOOD SCI TECHNOL, V111, P876, DOI 10.1016/j.lwt.2019.05.057
   Nunes KP, 2019, BRIT J PHARMACOL, V176, P1864, DOI 10.1111/bph.14438
   Only CG, 2021, EFSA J, V19, DOI 10.2903/j.efsa.2021.6506
   Pessione E, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.00876
   Ramalho JB, 2019, NUTRIENTS, V11, DOI 10.3390/nu11040901
   Rossi F, 1998, J APPL MICROBIOL, V85, P956, DOI 10.1111/j.1365-2672.1998.tb05259.x
   Rossi F, 2022, MICROORGANISMS, V10, DOI 10.3390/microorganisms10051023
   Rossi F, 2012, INT J DAIRY TECHNOL, V65, P401, DOI 10.1111/j.1471-0307.2012.00844.x
   Rousalova I, 2010, INT J ONCOL, V37, P1361, DOI 10.3892/ijo_00000788
   Saxami G, 2012, ANAEROBE, V18, P417, DOI 10.1016/j.anaerobe.2012.04.002
   Schifano E, 2019, MICROORGANISMS, V7, DOI 10.3390/microorganisms7020045
   Spyridopoulou K, 2021, NANOSCALE ADV, V3, P2516, DOI 10.1039/d0na00984a
   Toukam LL, 2021, J ETHNOPHARMACOL, V280, DOI 10.1016/j.jep.2021.114448
   Valente GLC, 2019, J DAIRY SCI, V102, P5957, DOI 10.3168/jds.2018-15938
   Wang GQ, 2019, FOOD FUNCT, V10, P5843, DOI [10.1039/c9fo01390c, 10.1039/C9FO01390C]
   Wasilewska E, 2019, J DAIRY SCI, V102, P37, DOI 10.3168/jds.2018-14520
   WHO, 2003, WHO TECH REP SER, V916, P1
   World Health Organization, 2020, International Federation of Resistance Fighters
   Yamashita M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12123620
   Yamashita M, 2019, FUNCT FOODS HEALTH D, V9, P52, DOI 10.31989/ffhd.v9i1.557
   Yang G, 2021, AQUACULTURE, V544, DOI 10.1016/j.aquaculture.2021.737038
   Yeom J, 2022, MICROORGANISMS, V10, DOI 10.3390/microorganisms10010048
   Yeom J, 2021, MICROORGANISMS, V9, DOI 10.3390/microorganisms9040673
   Yousefi M, 2023, FISH SHELLFISH IMMUN, V135, DOI 10.1016/j.fsi.2023.108652
   Zago M, 2011, FOOD MICROBIOL, V28, P1033, DOI 10.1016/j.fm.2011.02.009
   Zangrossi H, 2020, HBK BEHAV NEUROSCI, V31, P611, DOI 10.1016/B978-0-444-64125-0.00036-0
   Zhang J, 2017, J DAIRY SCI, V100, P6025, DOI 10.3168/jds.2016-12480
   Zhang J, 2014, J MICROBIOL BIOTECHN, V24, P225, DOI 10.4014/jmb.1308.08075
   Zhang WY, 2010, J BACTERIOL, V192, P5268, DOI 10.1128/JB.00802-10
   Zhao LA, 2022, J DAIRY SCI, V105, P7190, DOI 10.3168/jds.2022-21844
   Zhao X, 2019, J DAIRY SCI, V102, P5899, DOI 10.3168/jds.2018-16033
   Zheng YH, 2021, FRONT MICROBIOL, V12, DOI 10.3389/fmicb.2021.675492
NR 108
TC 7
Z9 7
U1 6
U2 35
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-2607
J9 MICROORGANISMS
JI Microorganisms
PD JUL
PY 2023
VL 11
IS 7
AR 1787
DI 10.3390/microorganisms11071787
PG 33
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA N3XI5
UT WOS:001036376700001
PM 37512959
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Liu, K
   Luo, M
   Wei, S
AF Liu, Kui
   Luo, Miao
   Wei, Shuang
TI The Bioprotective Effects of Polyphenols on Metabolic Syndrome against
   Oxidative Stress: Evidences and Perspectives
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID FATTY LIVER-DISEASE; DENSITY-LIPOPROTEIN CHOLESTEROL; CARDIOVASCULAR
   RISK-FACTORS; GREEN TEA EXTRACT; ANTIOXIDANT ACTIVITY; BLOOD-PRESSURE;
   DOUBLE-BLIND; IN-VITRO; RESVERATROL SUPPLEMENTATION; SERUM-LIPIDS
AB Polyphenols are the general designation of various kinds of phytochemicals, mainly classified as flavonoids and nonflavonoids. Polyphenolic compounds have been confirmed to exhibit numerous bioactivities and potential health benefits both in vivo and in vitro. Dietary polyphenols have been shown to significantly alleviate several manifestations of metabolic syndrome, namely, central obesity, hypertension, dyslipidemia, and high blood sugar. This review is aimed at discussing the bioprotective effects and related molecular mechanisms of polyphenols, mainly by increasing antioxidant capacity or oxygen scavenging capacity. Polyphenols can exert their antioxidative activity by balancing the organic oxidoreductase enzyme system, regulating antioxidant responsive signaling pathways, and restoring mitochondrial function. These data are helpful for providing new insights into the potential biological effects of polyphenolic compounds and the development of future antioxidant therapeutics.
C1 [Liu, Kui; Luo, Miao; Wei, Shuang] Huazhong Univ Sci & Technol, Tongji Med Coll, Hlth Minist, Key Lab Pulm Dis,Dept Resp & Crit Care Med,Tongji, Wuhan 430030, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology
RP Wei, S (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Hlth Minist, Key Lab Pulm Dis,Dept Resp & Crit Care Med,Tongji, Wuhan 430030, Hubei, Peoples R China.
EM wsdavid2001@163.com
RI Wei, Shuang/HSC-2591-2023
OI Luo, Miao/0000-0002-6474-7205; Wei, Shuang/0000-0001-5322-9667
FU National Natural Science Foundation of China [81772477, 81201848]
FX This work was supported by funding from the National Natural Science
   Foundation of China (No.81772477 and No. 81201848) awarded to Dr. Shuang
   Wei.
CR Acero N, 2019, FOOD CHEM, V279, P260, DOI 10.1016/j.foodchem.2018.12.008
   Adefegha S. A., 2018, Journal of Complementary & Integrative Medicine, V15, P20160159
   Alam MB, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18102069
   Amiot MJ, 2016, OBES REV, V17, P573, DOI 10.1111/obr.12409
   Astell KJ, 2013, COMPLEMENT THER MED, V21, P180, DOI 10.1016/j.ctim.2013.01.004
   Auberval N, 2017, EUR J NUTR, V56, P1467, DOI 10.1007/s00394-016-1192-2
   Bai XL, 2013, J SCI FOOD AGR, V93, P2502, DOI 10.1002/jsfa.6066
   Baird L, 2011, ARCH TOXICOL, V85, P241, DOI 10.1007/s00204-011-0674-5
   Bajpai VK, 2018, BIOMED PHARMACOTHER, V103, P1397, DOI 10.1016/j.biopha.2018.04.186
   Barbonetti A, 2016, REPROD TOXICOL, V66, P61, DOI 10.1016/j.reprotox.2016.09.014
   Baur JA, 2006, NATURE, V444, P337, DOI 10.1038/nature05354
   Bitzer ZT, 2016, MOL NUTR FOOD RES, V60, P2267, DOI 10.1002/mnfr.201501042
   Bonomini F, 2015, AGING DIS, V6, P109, DOI 10.14336/AD.2014.0305
   Bousová I, 2015, DRUG METAB REV, V47, P520, DOI 10.3109/03602532.2015.1089885
   Cao H, 2019, CRIT REV FOOD SCI, V59, P3371, DOI 10.1080/10408398.2018.1492900
   Chai SC, 2018, FOOD FUNCT, V9, P3185, DOI [10.1039/c8fo00468d, 10.1039/C8FO00468D]
   Chen G, 2015, J PHARM PHARM SCI, V18, P235, DOI 10.18433/J3N318
   Chen L, 2017, FRONT PHARMACOL, V7, DOI 10.3389/fphar.2016.00513
   Chen SH, 2015, DIGEST LIVER DIS, V47, P226, DOI 10.1016/j.dld.2014.11.015
   Chiva-Blanch G, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/5812401
   Chiva-Blanch G, 2013, CLIN NUTR, V32, P200, DOI 10.1016/j.clnu.2012.08.022
   Costabile G, 2019, CLIN NUTR, V38, P2727, DOI 10.1016/j.clnu.2018.11.028
   Dallas C, 2014, PHYTOTHER RES, V28, P212, DOI 10.1002/ptr.4981
   de Oliveira MM, 2018, J PHOTOCH PHOTOBIO B, V181, P127, DOI 10.1016/j.jphotobiol.2018.03.008
   Del Rio D, 2013, ANTIOXID REDOX SIGN, V18, P1818, DOI 10.1089/ars.2012.4581
   Dostal AM, 2016, J NUTR, V146, P256, DOI 10.3945/jn.115.219238
   Dueñas M, 2010, J PHARMACEUT BIOMED, V51, P443, DOI 10.1016/j.jpba.2009.04.007
   Erlund I, 2008, AM J CLIN NUTR, V87, P323, DOI 10.1093/ajcn/87.2.323
   Espinosa-Moncada J, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111639
   Faghihzadeh F, 2015, BRIT J NUTR, V114, P796, DOI 10.1017/S0007114515002433
   Faghihzadeh F, 2014, NUTR RES, V34, P837, DOI 10.1016/j.nutres.2014.09.005
   Fang C, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201800129
   Fantini M, 2015, INT J MOL SCI, V16, P9236, DOI 10.3390/ijms16059236
   Fourny N, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010105
   Fukui H, 2007, P NATL ACAD SCI USA, V104, P14163, DOI 10.1073/pnas.0705738104
   Grundy SM, 2016, TRENDS CARDIOVAS MED, V26, P364, DOI 10.1016/j.tcm.2015.10.004
   Hameed I, 2015, WORLD J DIABETES, V6, P598, DOI 10.4239/wjd.v6.i4.598
   Heim KE, 2002, J NUTR BIOCHEM, V13, P572, DOI 10.1016/S0955-2863(02)00208-5
   Hsu HT, 2018, BMC COMPLEM ALTERN M, V18, DOI 10.1186/s12906-018-2278-6
   Hyung JH, 2016, EUR J PHARMACOL, V793, P43, DOI 10.1016/j.ejphar.2016.11.002
   Ishida N, 2018, INT J FOOD SCI NUTR, V69, P598, DOI 10.1080/09637486.2017.1386629
   Janssens PLHR, 2015, J NUTR, V145, P864, DOI 10.3945/jn.114.207829
   Jian TY, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19103005
   Jomaa B, 2015, ALTEX-ALTERN ANIM EX, V32, P191, DOI 10.14573/altex.1412201
   Kelly T, 2008, INT J OBESITY, V32, P1431, DOI 10.1038/ijo.2008.102
   Kim MH, 2011, PHARMAZIE, V66, P293, DOI 10.1691/ph.2011.0798
   Kim YJ, 2011, FOOD CHEM TOXICOL, V49, P2196, DOI 10.1016/j.fct.2011.06.012
   Koli R, 2015, NUTR J, V14, DOI 10.1186/s12937-015-0075-3
   Kumar S, 2012, CELL MOL BIOL, V58, P174, DOI 10.1170/T938
   Lagouge M, 2006, CELL, V127, P1109, DOI 10.1016/j.cell.2006.11.013
   Lemanska K, 2004, FREE RADICAL RES, V38, P639, DOI 10.1080/10715760410001694062
   Levonen AL, 2004, BIOCHEM J, V378, P373, DOI 10.1042/BJ20031049
   Li AN, 2014, NUTRIENTS, V6, P6020, DOI 10.3390/nu6126020
   Li XW, 2018, MOLECULES, V23, DOI 10.3390/molecules23123245
   Lin LZ, 2018, FOOD CHEM, V253, P108, DOI 10.1016/j.foodchem.2018.01.139
   Liu H, 2014, J BIOCHEM MOL TOXIC, V28, P465, DOI 10.1002/jbt.21586
   Loboda A, 2016, CELL MOL LIFE SCI, V73, P3221, DOI 10.1007/s00018-016-2223-0
   López-Alarcón C, 2013, ANAL CHIM ACTA, V763, P1, DOI 10.1016/j.aca.2012.11.051
   Lunder M, 2019, PLANT FOOD HUM NUTR, V74, P47, DOI 10.1007/s11130-018-0698-6
   Ma MC, 2005, J BIOL CHEM, V280, P16208, DOI 10.1074/jbc.M408055200
   Ma YF, 2019, J DAIRY SCI, V102, P1658, DOI 10.3168/jds.2018-15047
   Madreiter-Sokolowski CT, 2017, NUTRIENTS, V9, DOI 10.3390/nu9101117
   Marranzano M, 2018, INT J FOOD SCI NUTR, V69, P1020, DOI 10.1080/09637486.2018.1452900
   Martínez-Maqueda D, 2018, FOOD FUNCT, V9, P6010, DOI [10.1039/c8fo01323c, 10.1039/C8FO01323C]
   Mishra A, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/915436
   Momose Y, 2016, INT J FOOD SCI NUTR, V67, P606, DOI 10.1080/09637486.2016.1196655
   Mozaffarian D, 2015, CIRCULATION, V131, pE29, DOI 10.1161/CIR.0000000000000152
   Mumford SL, 2015, J NUTR, V145, P2535, DOI 10.3945/jn.115.214973
   Mursu J, 2005, J AGR FOOD CHEM, V53, P3017, DOI 10.1021/jf048448x
   Nauman M, 2018, BMC COMPLEM ALTERN M, V18, DOI 10.1186/s12906-018-2143-7
   Nosál R, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/706269
   Ogurtsova K, 2017, DIABETES RES CLIN PR, V128, P40, DOI 10.1016/j.diabres.2017.03.024
   Panahi Y, 2017, DRUG RES, V67, P244, DOI 10.1055/s-0043-100019
   Panneerselvam M, 2013, MOL NUTR FOOD RES, V57, P1007, DOI 10.1002/mnfr.201300026
   Peng JM, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/7202695
   Pereira RB, 2013, MOLECULES, V18, P8858, DOI 10.3390/molecules18088858
   Psotová J, 2004, PHYTOTHER RES, V18, P516, DOI 10.1002/ptr.1462
   Qian XY, 2019, FOOD FUNCT, V10, P867, DOI [10.1039/c8fo02124d, 10.1039/C8FO02124D]
   Qureshi AA, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-239
   Rahmani S, 2016, PHYTOTHER RES, V30, P1540, DOI 10.1002/ptr.5659
   Rangel-Huerta OD, 2015, J NUTR, V145, P1808, DOI 10.3945/jn.115.213660
   Rassaf T, 2016, CLIN J AM SOC NEPHRO, V11, P108, DOI 10.2215/CJN.05560515
   Rienks J, 2018, AM J CLIN NUTR, V108, P49, DOI 10.1093/ajcn/nqy083
   Rostami A, 2015, ARYA ATHEROSCLER, V11, P21
   Rowley TJ, 2017, J NUTR BIOCHEM, V49, P30, DOI 10.1016/j.jnutbio.2017.07.015
   Salazar G, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19051327
   Samavat H, 2016, AM J CLIN NUTR, V104, P1671, DOI 10.3945/ajcn.116.137075
   Selma MV, 2009, J AGR FOOD CHEM, V57, P6485, DOI 10.1021/jf902107d
   Seyyedebrahimi S, 2018, ACTA DIABETOL, V55, P341, DOI 10.1007/s00592-017-1098-3
   Shrime MG, 2011, J NUTR, V141, P1982, DOI 10.3945/jn.111.145482
   Song EK, 2018, NUTR RES
   Sottero B, 2015, MED RES REV, V35, P968, DOI 10.1002/med.21349
   Sun YJ, 2019, FOOD CHEM, V279, P321, DOI 10.1016/j.foodchem.2018.12.019
   Sung H, 2019, CA-CANCER J CLIN, V69, P88, DOI 10.3322/caac.21499
   Szelényi P, 2019, BIOFACTORS, V45, P236, DOI 10.1002/biof.1477
   Tanigawa S, 2007, FREE RADICAL BIO MED, V42, P1690, DOI 10.1016/j.freeradbiomed.2007.02.017
   Taubert D, 2007, JAMA-J AM MED ASSOC, V298, P49, DOI 10.1001/jama.298.1.49
   Thomas R, 2014, PROSTATE CANCER P D, V17, P180, DOI 10.1038/pcan.2014.6
   Tian C, 2016, SCI REP-UK, V6, DOI 10.1038/srep24353
   Tian C, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0053796
   Tian C, 2013, GENES NUTR, V8, P231, DOI 10.1007/s12263-012-0319-1
   Timmers S, 2011, CELL METAB, V14, P612, DOI 10.1016/j.cmet.2011.10.002
   Tsai MH, 2017, INT J BIOCHEM CELL B, V88, P113, DOI 10.1016/j.biocel.2017.05.015
   Tynkkynen T, 2012, METABOLOMICS, V8, P386, DOI 10.1007/s11306-011-0323-2
   Vetrani C, 2018, ACTA DIABETOL, V55, P149, DOI 10.1007/s00592-017-1075-x
   Wolfe KL, 2007, J AGR FOOD CHEM, V55, P8896, DOI 10.1021/jf0715166
   Wu LY, 2004, P NATL ACAD SCI USA, V101, P7094, DOI 10.1073/pnas.0402004101
   Xie LY, 2017, NUTR RES, V37, P67, DOI 10.1016/j.nutres.2016.12.007
   Yamazaki KG, 2014, INT J CARDIOL, V175, P297, DOI 10.1016/j.ijcard.2014.05.009
   Zou B, 2018, FOOD CHEM, V255, P23, DOI 10.1016/j.foodchem.2018.02.028
   Zuo T, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/8589318
   Zyzelewicz D, 2018, FOOD RES INT, V112, P209, DOI 10.1016/j.foodres.2018.06.039
NR 112
TC 82
Z9 84
U1 2
U2 32
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD NOV 30
PY 2019
VL 2019
AR 6713194
DI 10.1155/2019/6713194
PG 16
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA JU6DG
UT WOS:000501764600002
PM 31885810
OA Green Published
DA 2025-06-11
ER

PT J
AU Guo, B
   Zhuang, TT
   Xu, F
   Lin, X
   Li, FXZ
   Shan, SK
   Wu, F
   Zhong, JY
   Wang, Y
   Zheng, MH
   Xu, QS
   Ehsan, UMH
   Yuan, LQ
AF Guo, Bei
   Zhuang, Tongtian
   Xu, Feng
   Lin, Xiao
   Li, Fuxingzi
   Shan, Su-Kang
   Wu, Feng
   Zhong, Jia-Yu
   Wang, Yi
   Zheng, Ming-Hui
   Xu, Qiu-Shuang
   Ehsan, Ullah Muhammad Hasnain
   Yuan, Ling-Qing
TI New Insights Into Implications of CTRP3 in Obesity, Metabolic
   Dysfunction, and Cardiovascular Diseases: Potential of Therapeutic
   Interventions
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE adipocytokines; CTRP3; insulin resistance; therapeutic targets; type 2
   diabetes mellitus; obesity; metabolic syndrome; cardiovascular disorders
ID FACTOR-RELATED PROTEIN-3; REPEAT-CONTAINING SEQUENCE; MUSCLE-CELL
   CALCIFICATION; C1Q/TNF-RELATED PROTEIN-3; ADIPOSE-TISSUE; COLLAGENOUS
   REPEAT; OXIDATIVE STRESS; ADIPONECTIN MULTIMERIZATION; CHROMOSOMAL
   LOCALIZATION; PROMOTES PROLIFERATION
AB Adipose tissue, as the largest endocrine organ, secretes many biologically active molecules circulating in the bloodstream, collectively termed adipocytokines, which not only regulate the metabolism but also play a role in pathophysiological processes. C1q tumor necrosis factor (TNF)-related protein 3 (CTRP3) is a member of C1q tumor necrosis factor-related proteins (CTRPs), which is a paralog of adiponectin. CTRP3 has a wide range of effects on glucose/lipid metabolism, inflammation, and contributes to cardiovascular protection. In this review, we comprehensively discussed the latest research on CTRP3 in obesity, diabetes, metabolic syndrome, and cardiovascular diseases.
C1 [Guo, Bei; Xu, Feng; Li, Fuxingzi; Shan, Su-Kang; Zhong, Jia-Yu; Wang, Yi; Zheng, Ming-Hui; Xu, Qiu-Shuang; Ehsan, Ullah Muhammad Hasnain; Yuan, Ling-Qing] Cent South Univ, Natl Clin Res Ctr Metab Dis, Hunan Prov Key Lab Metab Bone Dis, Xiangya Hosp 2, Changsha, Peoples R China.
   [Guo, Bei; Xu, Feng; Li, Fuxingzi; Shan, Su-Kang; Zhong, Jia-Yu; Wang, Yi; Zheng, Ming-Hui; Xu, Qiu-Shuang; Ehsan, Ullah Muhammad Hasnain; Yuan, Ling-Qing] Cent South Univ, Xiangya Hosp 2, Dept Endocrinol & Metab, Changsha, Peoples R China.
   [Zhuang, Tongtian] Fourth Mil Med Univ, Xijing Hosp, Dept Dermatol, Xian, Peoples R China.
   [Lin, Xiao] Cent South Univ, Dept Radiol, Xiangya Hosp 2, Changsha, Peoples R China.
   [Wu, Feng] Cent South Univ, Dept Pathol, Xiangya Hosp 2, Changsha, Peoples R China.
C3 Central South University; Central South University; Air Force Medical
   University; Central South University; Central South University
RP Yuan, LQ (corresponding author), Cent South Univ, Natl Clin Res Ctr Metab Dis, Hunan Prov Key Lab Metab Bone Dis, Xiangya Hosp 2, Changsha, Peoples R China.; Yuan, LQ (corresponding author), Cent South Univ, Xiangya Hosp 2, Dept Endocrinol & Metab, Changsha, Peoples R China.
EM allenylq@csu.edu.cn
RI Shan, Su-kang/JFS-7113-2023; Xu, Feng/AAE-6486-2020; Yuan,
   Ling-Qing/HZL-9093-2023; Wang, Yi/IZE-7930-2023; Ullah,
   Ehsan/IYJ-5471-2023; Yuan, Ling-Qing/D-2102-2019
OI Yuan, Ling-Qing/0000-0001-8602-7113; lin, xiao/0000-0002-6039-3630; Xu,
   Feng/0000-0003-0902-2858
FU National Natural Science Foundation of China [81770881, 82070910]
FX This work was supported by funding from the National Natural Science
   Foundation of China (Nos. 81770881 and 82070910).
CR Akiyama H, 2006, FEBS J, V273, P2257, DOI 10.1111/j.1742-4658.2006.05240.x
   Akiyama H, 2007, MOL CELL BIOCHEM, V304, P243, DOI 10.1007/s11010-007-9506-6
   Akiyama H, 2009, ONCOL REP, V21, P1477, DOI 10.3892/or_00000377
   Akoumianakis I, 2017, CARDIOVASC RES, V113, P999, DOI 10.1093/cvr/cvx111
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Apovian CM, 2008, ARTERIOSCL THROM VAS, V28, P1654, DOI 10.1161/ATVBAHA.108.170316
   Asada S, 2007, CELL SIGNAL, V19, P519, DOI 10.1016/j.cellsig.2006.08.015
   Ban B, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0112931
   BANNISTER AJ, 1994, NUCLEIC ACIDS RES, V22, P5173, DOI 10.1093/nar/22.24.5173
   Brandl K, 2005, J ENDOTOXIN RES, V11, P197, DOI 10.1179/096805105X58670
   Chen L, 2019, INFLAMMATION, V42, P1350, DOI 10.1007/s10753-019-00996-1
   Cherrington AD, 1999, DIABETES, V48, P1198, DOI 10.2337/diabetes.48.5.1198
   Cho NH, 2018, DIABETES RES CLIN PR, V138, P271, DOI 10.1016/j.diabres.2018.02.023
   Choi HY, 2013, DIABETES CARE, V36, P3321, DOI 10.2337/dc13-0178
   Choi KM, 2014, CARDIOVASC DIABETOL, V13, DOI 10.1186/1475-2840-13-14
   Choi KM, 2012, DIABETES, V61, P2932, DOI 10.2337/db12-0217
   Cui RR, 2012, CARDIOVASC RES, V96, P320, DOI 10.1093/cvr/cvs258
   Dagenais GR, 2020, LANCET, V395, P785, DOI 10.1016/S0140-6736(19)32007-0
   Deng WQ, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/s13098-015-0029-0
   Donath MY, 2011, NAT REV IMMUNOL, V11, P98, DOI 10.1038/nri2925
   Flehmig G, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0099785
   Gao C, 2019, BMC CARDIOVASC DISOR, V19, DOI 10.1186/s12872-019-1117-0
   Graziani F, 2011, AM J CARDIOL, V107, P1656, DOI 10.1016/j.amjcard.2011.01.053
   Gross DN, 2009, CURR DIABETES REP, V9, P208, DOI 10.1007/s11892-009-0034-5
   Hasegawa N, 2018, AM J PHYSIOL-REG I, V314, pR94, DOI 10.1152/ajpregu.00212.2017
   Hou Q, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0134006
   Hu TY, 2019, J CELL BIOCHEM, V120, P5729, DOI 10.1002/jcb.27859
   Jiang HM, 2018, AM J CARDIOL, V122, P1244, DOI 10.1016/j.amjcard.2018.06.024
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kim MJ, 2012, MOL CELL BIOCHEM, V368, P111, DOI 10.1007/s11010-012-1349-0
   Kishore U, 2004, TRENDS IMMUNOL, V25, P551, DOI 10.1016/j.it.2004.08.006
   Komosinska-Vassev K, 2019, J CLIN MED, V8, DOI 10.3390/jcm8060805
   Kopp A, 2010, ENDOCRINOLOGY, V151, P5267, DOI 10.1210/en.2010-0571
   Lei X, 2015, AM J PHYSIOL-ENDOC M, V308, pE792, DOI 10.1152/ajpendo.00383.2014
   Li JY, 2017, EUR REV MED PHARMACO, V21, P5702, DOI 10.26355/eurrev_201712_14016
   Li X, 2015, J ENDOCRINOL INVEST, V38, P73, DOI 10.1007/s40618-014-0156-8
   Li X, 2014, ENDOCR J, V61, P1153, DOI 10.1507/endocrj.EJ14-0161
   Li X, 2014, J DIABETES RES, V2014, DOI 10.1155/2014/398518
   Li Y, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0164593
   Liao JF, 1998, J BIOL CHEM, V273, P27320, DOI 10.1074/jbc.273.42.27320
   Lin SH, 2014, INT J CLIN EXP PATHO, V7, P2199
   Liu ML, 2014, BEST PRACT RES CL EN, V28, P25, DOI 10.1016/j.beem.2013.06.003
   Liu ML, 2012, DIABETES, V61, P2776, DOI 10.2337/db12-0169
   Liu M, 2008, P NATL ACAD SCI USA, V105, P18302, DOI 10.1073/pnas.0806341105
   Liu Y, 2018, REDOX BIOL, V18, P211, DOI 10.1016/j.redox.2018.07.007
   Ma ZG, 2019, CARDIOVASC RES, V115, P1067, DOI 10.1093/cvr/cvy279
   Ma ZG, 2017, DIABETOLOGIA, V60, P1126, DOI 10.1007/s00125-017-4232-4
   Maeda T, 2006, J CELL PHYSIOL, V206, P537, DOI 10.1002/jcp.20493
   Maeda T, 2001, J BIOL CHEM, V276, P3628, DOI 10.1074/jbc.M007898200
   Maeda T, 2010, CELL BIOL INT, V34, P261, DOI 10.1042/CBI20090043
   Miyake K, 2002, J CLIN INVEST, V110, P1483, DOI 10.1172/JCI200215880
   Mohamadinarab M, 2020, IUBMB LIFE, V72, P1698, DOI 10.1002/iub.2293
   Moore KJ, 2011, CELL, V145, P341, DOI 10.1016/j.cell.2011.04.005
   Moradi N, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0215617
   Nishimoto H, 2017, CELL BIOL INT, V41, P197, DOI 10.1002/cbin.10674
   Ono H, 2003, DIABETES, V52, P2905, DOI 10.2337/diabetes.52.12.2905
   Ota T, 2013, DIABETES METAB J, V37, P165
   Otani M, 2012, CYTOKINE, V58, P238, DOI 10.1016/j.cyto.2012.01.018
   Ouchi N, 2000, CIRCULATION, V102, P1296, DOI 10.1161/01.CIR.102.11.1296
   Ouchi N, 2003, CURR OPIN LIPIDOL, V14, P561, DOI 10.1097/00041433-200312000-00003
   Ouchi N, 2011, NAT REV IMMUNOL, V11, P85, DOI 10.1038/nri2921
   Pajvani UB, 2003, J BIOL CHEM, V278, P9073, DOI 10.1074/jbc.M207198200
   Petersen PS, 2016, PHYSIOL REP, V4, DOI 10.14814/phy2.12735
   Peterson JM, 2013, AM J PHYSIOL-GASTR L, V305, pG214, DOI 10.1152/ajpgi.00102.2013
   Peterson JM, 2010, J BIOL CHEM, V285, P39691, DOI 10.1074/jbc.M110.180695
   Qu H, 2015, J CLIN LIPIDOL, V9, P289, DOI 10.1016/j.jacl.2015.03.006
   Rehorst WA, 2019, ACTA NEUROPATHOL COM, V7, DOI 10.1186/s40478-019-0806-3
   Rosen ED, 2006, NATURE, V444, P847, DOI 10.1038/nature05483
   Schäffler A, 2007, OBESITY, V15, P303, DOI 10.1038/oby.2007.566
   Schäffler A, 2004, BBA-GENE STRUCT EXPR, V1678, P150, DOI 10.1016/j.bbaexp.2004.02.006
   Schäffler A, 2003, BBA-GENE STRUCT EXPR, V1630, P123, DOI 10.1016/j.bbaexp.2003.08.013
   Schäffler A, 2003, BBA-GENE STRUCT EXPR, V1628, P64, DOI 10.1016/S0167-4781(03)00114-3
   Scherer PE, 2006, DIABETES, V55, P1537, DOI 10.2337/db06-0263
   Schmid A, 2012, EXP CLIN ENDOCR DIAB, V120, P611, DOI 10.1055/s-0032-1323803
   Shan SK, 2019, CURR PHARM DESIGN, V25, P4536, DOI 10.2174/1381612825666191127114054
   Shapiro L, 1998, CURR BIOL, V8, P335, DOI 10.1016/S0960-9822(98)70133-2
   SHEPHERD PR, 1993, J BIOL CHEM, V268, P22243
   Song YL, 2020, INT J CLIN EXP PATHO, V13, P142
   Tan BK, 2013, J CLIN ENDOCR METAB, V98, pE1891, DOI 10.1210/jc.2013-2227
   Trogen G, 2018, AM J PHYSIOL-ENDOC M, V315, pE949, DOI 10.1152/ajpendo.00050.2018
   Wagner RM, 2016, PEERJ, V4, DOI 10.7717/peerj.2573
   Wang F, 2019, ANAL CELL PATHOL, V2019, DOI 10.1155/2019/7405602
   Wang SH, 2016, FRONT CELL NEUROSCI, V10, DOI 10.3389/fncel.2016.00237
   Wei WY, 2018, MOL CELL ENDOCRINOL, V476, P27, DOI 10.1016/j.mce.2018.04.006
   Weigert J, 2005, FEBS LETT, V579, P5565, DOI 10.1016/j.febslet.2005.09.022
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Wölfing B, 2008, OBESITY, V16, P1481, DOI 10.1038/oby.2008.206
   Wolf RM, 2016, AM J PHYSIOL-ENDOC M, V310, pE332, DOI 10.1152/ajpendo.00248.2015
   Wolf RM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0133955
   Wong GW, 2008, BIOCHEM J, V416, P161, DOI 10.1042/BJ20081240
   Wong GW, 2004, P NATL ACAD SCI USA, V101, P10302, DOI 10.1073/pnas.0403760101
   Wu D, 2015, J MOL MED, V93, P1311, DOI 10.1007/s00109-015-1309-8
   Wu F, 2019, ENDOCR-RELAT CANCER, V26, P525, DOI 10.1530/ERC-19-0008
   Xu F, 2020, J PINEAL RES, V68, DOI 10.1111/jpi.12631
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yan ZY, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0178253
   Yang B, 2017, BRAIN RES, V1657, P176, DOI 10.1016/j.brainres.2016.11.016
   Yi W, 2012, CIRCULATION, V125, P3159, DOI 10.1161/CIRCULATIONAHA.112.099937
   Yoo HJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055744
   Yoshizawa M, 1998, DIABETES RES CLIN PR, V42, P65, DOI 10.1016/S0168-8227(98)00091-6
   Yuan YP, 2018, J MOL CELL CARDIOL, V114, P38, DOI 10.1016/j.yjmcc.2017.10.008
   Zhang B, 2019, CELL DEATH DIS, V10, DOI 10.1038/s41419-019-1749-0
   Zhang CL, 2017, CELL CALCIUM, V66, P90, DOI 10.1016/j.ceca.2017.06.009
   Zhang CL, 2017, BBA-GEN SUBJECTS, V1861, P3085, DOI 10.1016/j.bbagen.2016.10.022
   Zhang J, 2019, ARTIF CELL NANOMED B, V47, P3758, DOI 10.1080/21691401.2019.1666864
   Zhang JX, 2018, CYTOKINE, V106, P131, DOI 10.1016/j.cyto.2017.10.023
   Zhang RC, 2016, AM J NEPHROL, V43, P460, DOI 10.1159/000446353
   Zhang ZB, 2019, CELL DEATH DIS, V10, DOI 10.1038/s41419-019-1760-5
   Zheng QJ, 2011, ARTERIOSCL THROM VAS, V31, P2616, DOI 10.1161/ATVBAHA.111.231050
   Zhou WJ, 2018, CLIN CHIM ACTA, V479, P79, DOI 10.1016/j.cca.2018.01.003
   Zhou Y, 2014, ARTERIOSCL THROM VAS, V34, P1002, DOI 10.1161/ATVBAHA.114.303301
   Zhu HT, 2020, EXP THER MED, V19, P2243, DOI 10.3892/etm.2020.8467
NR 112
TC 27
Z9 28
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD DEC 3
PY 2020
VL 11
AR 570270
DI 10.3389/fphys.2020.570270
PG 11
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA PF8TO
UT WOS:000599320100001
PM 33343381
OA Green Published, gold
DA 2025-06-11
ER

PT S
AU Akyuz, A
AF Akyuz, Aydin
BE Xiao, J
TI Exercise and Coronary Heart Disease
SO PHYSICAL EXERCISE FOR HUMAN HEALTH
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
DE Coronary heart disease; Dynamic exercise; Static exercise
ID CARDIOVASCULAR-ABNORMALITIES PREAMBLE; ELEVATION MYOCARDIAL-INFARCTION;
   PRACTICE GUIDELINES COMMITTEE; HEALTH-CARE PROFESSIONALS; ASSOCIATION
   TASK-FORCE; QUALITY-OF-LIFE; CARDIAC REHABILITATION; ARTERY-DISEASE;
   PHYSICAL-ACTIVITY; AMERICAN-COLLEGE
AB Coronary artery disease (CAD) can be obstructive or nonobstructive. Patients with nonobstructive and stable angina pectoris are usually women. Nonobstructive CAD is caused by endothelial dysfunction at the microvascular level, such as cardiac syndrome X and coronary slow flow syndrome. Even if coronary anatomy is nonobstructive, the presence of myocardial ischemia is a major determinant for the exercise program. CAD is a chronic inflammatory disease, and the progression of the disease can lead to a rapid change in the functional capacity of CAD patients. Exercise training is a major component of cardiac rehabilitation and reduces cardiovascular mortality, morbidity, and rehospitalization as well as improves psychological stress and controls risk factors of CAD, such as diabetes mellitus, hypertension, and obesity. It is possible that the quality of life of patients with CAD can be improved by using appropriate exercise therapy. However, the exercise programs among CAD patients are highly underutilized. This chapter will summarize the research progress of exercise in the prevention and treatment of CAD as well as how to create safe exercise programs and the importance of exercise for patients with CAD. In addition, exercise training has fundamental beneficial effects on ischemic and nonischemic heart failure.
C1 [Akyuz, Aydin] Namik Kemal Univ, Univ Hosp, Dept Cardiol, Fac Med, Tekirdag, Turkey.
C3 Namik Kemal University
RP Akyuz, A (corresponding author), Namik Kemal Univ, Univ Hosp, Dept Cardiol, Fac Med, Tekirdag, Turkey.
EM aakyuz@nku.edu.tr
CR Anderson L, 2016, COCHRANE DB SYST REV, DOI [10.1016/j.jacc.2015.10.044, 10.1002/14651858.CD001800.pub3]
   [Anonymous], 2007, JAMA-J AM MED ASSOC, DOI DOI 10.1001/jama.297.2.169
   [Anonymous], 2010, BMJ BRIT MED J, DOI DOI 10.1136/BMJ.B5631
   Arena R, 2007, CIRCULATION, V116, P329, DOI 10.1161/CIRCULATIONAHA.106.184461
   Artham SM, 2008, SOUTH MED J, V101, P262, DOI 10.1097/SMJ.0b013e318164dfa8
   AUSTIN MA, 1990, CIRCULATION, V82, P495, DOI 10.1161/01.CIR.82.2.495
   Balady GJ, 2011, CIRCULATION, V124, P2951, DOI 10.1161/CIR.0b013e31823b21e2
   BERTAGNOLI K, 1990, AM J CARDIOL, V65, P314, DOI 10.1016/0002-9149(90)90294-B
   Blanchard CM, 2001, J SCI MED SPORT, V4, P30, DOI 10.1016/S1440-2440(01)80005-0
   Braunwald E, 2000, CIRCULATION, V102, P1193, DOI 10.1161/01.CIR.102.10.1193
   Braunwald E, 2002, J AM COLL CARDIOL, V40, P1366, DOI 10.1016/S0735-1097(02)02336-7
   Caulin-Glaser Teresa, 2005, J Cardiopulm Rehabil, V25, P332, DOI 10.1097/00008483-200511000-00003
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   CLAUSEN JP, 1976, CIRCULATION, V53, P436, DOI 10.1161/01.CIR.53.3.436
   CLAUSEN JP, 1976, PROG CARDIOVASC DIS, V18, P459, DOI 10.1016/0033-0620(76)90012-8
   Colbert LH, 2004, J AM GERIATR SOC, V52, P1098, DOI 10.1111/j.1532-5415.2004.52307.x
   Fletcher GF, 2001, CIRCULATION, V104, P1694, DOI 10.1161/hc3901.095960
   Foote RS, 2004, J AM COLL CARDIOL, V44, P1980, DOI 10.1016/j.jacc.2004.08.045
   Franco OH, 2005, ARCH INTERN MED, V165, P2355, DOI 10.1001/archinte.165.20.2355
   Garber CE, 2011, MED SCI SPORT EXER, V43, P1334, DOI 10.1249/MSS.0b013e318213fefb
   Gielen S, 2001, CIRCULATION, V103, pE1
   Goel K, 2011, CIRCULATION, V123, P2344, DOI 10.1161/CIRCULATIONAHA.110.983536
   Goldhammer E, 2005, INT J CARDIOL, V100, P93, DOI 10.1016/j.ijcard.2004.08.073
   Grundy SM, 1999, J AM COLL CARDIOL, V34, P1348, DOI 10.1016/S0735-1097(99)00387-3
   Gurfinkel EP, 2002, CIRCULATION, V105, P2143, DOI 10.1161/01.CIR.0000016182.85461.F4
   Hansson GK, 2006, NAT REV IMMUNOL, V6, P508, DOI 10.1038/nri1882
   HIRZEL HO, 1985, J AM COLL CARDIOL, V6, P275, DOI 10.1016/S0735-1097(85)80160-1
   Huang KS, 2015, EUR J PREV CARDIOL, V22, P959, DOI 10.1177/2047487314561168
   Ibanez B, 2018, EUR HEART J, V39, P119, DOI 10.1093/eurheartj/ehx393
   Jin K, 2019, EUR J CARDIOVASC NUR, V18, P260, DOI 10.1177/1474515119826510
   Kavanagh T, 2003, J AM COLL CARDIOL, V42, P2139, DOI 10.1016/j.jacc.2003.07.028
   Keytel LR, 2005, J SPORT SCI, V23, P289, DOI 10.1080/02640410470001730089
   Kodama S, 2009, JAMA-J AM MED ASSOC, V301, P2024, DOI 10.1001/jama.2009.681
   Koenig W, 2000, CORONARY ARTERY DIS, V11, P123, DOI 10.1097/00019501-200003000-00006
   Lavie C J, 2000, J Cardiopulm Rehabil, V20, P235, DOI 10.1097/00008483-200007000-00004
   Lavie Carl J, 2008, J Cardiometab Syndr, V3, P136, DOI 10.1111/j.1559-4572.2008.00002.x
   Lavie CJ, 2011, PROG CARDIOVASC DIS, V53, P464, DOI 10.1016/j.pcad.2011.03.007
   Lavie CJ, 2011, PROG CARDIOVASC DIS, V53, P397, DOI 10.1016/j.pcad.2011.02.008
   Lavie CJ, 2009, MAYO CLIN PROC, V84, P373, DOI [10.4065/84.4.373, 10.1016/S0025-6196(11)60548-X]
   Lavie CJ, 1996, AM J CARDIOL, V78, P1286, DOI 10.1016/S0002-9149(96)00614-5
   Lavie CJ, 1997, AM J CARDIOL, V79, P397, DOI 10.1016/S0002-9149(97)89239-9
   LAVIE CJ, 1994, AM J CARDIOL, V74, P1192, DOI 10.1016/0002-9149(94)90546-0
   LEON AS, 1985, MED CLIN N AM, V69, P3, DOI 10.1016/S0025-7125(16)31055-0
   LERNER DJ, 1986, AM HEART J, V111, P383, DOI 10.1016/0002-8703(86)90155-9
   Libby P, 2012, ARTERIOSCL THROM VAS, V32, P2045, DOI 10.1161/ATVBAHA.108.179705
   Libby P, 2009, J AM COLL CARDIOL, V54, P2129, DOI 10.1016/j.jacc.2009.09.009
   Linke A, 2001, J AM COLL CARDIOL, V37, P392, DOI 10.1016/S0735-1097(00)01108-6
   Lloyd-Jones D, 2010, CIRCULATION, V121, P948, DOI 10.1161/CIRCULATIONAHA.109.192666
   Lucini D, 2002, AM HEART J, V143, P977, DOI 10.1067/mhj.2002.123117
   Luk TH, 2012, EUR J PREV CARDIOL, V19, P830, DOI 10.1177/1741826711415679
   Mancia G, 2003, J HYPERTENS, V21, P1011, DOI 10.1097/01.hjh.0000059051.65882.32
   Maron BJ, 2015, CIRCULATION, V132, pE256, DOI 10.1161/CIR.0000000000000236
   Maron BJ, 2015, J AM COLL CARDIOL, V66, P2343, DOI 10.1016/j.jacc.2015.09.032
   Mezzani A, 2013, EUR J PREV CARDIOL, V20, P442, DOI 10.1177/2047487312460484
   Milani R V, 1995, J Cardiopulm Rehabil, V15, P439, DOI 10.1097/00008483-199511000-00008
   MILANI RV, 1995, AM J CARDIOL, V75, P940, DOI 10.1016/S0002-9149(99)80693-6
   Milani RV, 2003, AM J CARDIOL, V92, P50, DOI 10.1016/S0002-9149(03)00464-8
   Moholdt T, 2014, J SCI MED SPORT, V17, P506, DOI 10.1016/j.jsams.2013.07.007
   Niessner A, 2006, ATHEROSCLEROSIS, V186, P160, DOI 10.1016/j.atherosclerosis.2005.06.047
   OCONNOR GT, 1989, CIRCULATION, V80, P234, DOI 10.1161/01.CIR.80.2.234
   Palmefors H, 2014, ATHEROSCLEROSIS, V235, P150, DOI 10.1016/j.atherosclerosis.2014.04.026
   Pattyn N, 2018, SPORTS MED, V48, P1189, DOI 10.1007/s40279-018-0885-5
   Perk J, 2013, G ITAL CARDIOL, V14, P328, DOI 10.1714/1264.13964
   Piepoli MF, 2010, EUR HEART J, V31, P1967, DOI 10.1093/eurheartj/ehq236
   RAHIMTOOLA SH, 1995, AM J CARDIOL, V75, pE16, DOI 10.1016/S0002-9149(99)80443-3
   Ribeiro F, 2010, INT J CARDIOL, V141, P214, DOI 10.1016/j.ijcard.2009.09.548
   SANCHEZ J, 1979, ERGONOMICS, V22, P935, DOI 10.1080/00140137908924668
   Scardovi AB, 2006, MED SCI MONITOR, V12, pCR191
   Sierra-Johnson J, 2008, EUR J CARDIOV PREV R, V15, P336, DOI 10.1097/HJR.0b013e3282f48348
   Smith SC, 2011, J AM COLL CARDIOL, V58, P2432, DOI 10.1016/j.jacc.2011.10.824
   Swift DL, 2013, CIRC J, V77, P281, DOI 10.1253/circj.CJ-13-0007
   Swirski FK, 2013, SCIENCE, V339, P161, DOI 10.1126/science.1230719
   Thompson PD, 2003, ARTERIOSCL THROM VAS, V23, pE42, DOI 10.1161/01.ATV.0000089628.63625.D4
   Tolga S, 2016, TURK J SPORTS MED, V51
   Vanhees L, 2004, EUR J CARDIOV PREV R, V11, P304, DOI 10.1097/01.hjr.0000136458.44614.a2
   VANHEES L, 1995, AM J CARDIOL, V76, P1014, DOI 10.1016/S0002-9149(99)80287-2
   Jaureguizar KV, 2016, J CARDIOPULM REHABIL, V36, P96, DOI 10.1097/HCR.0000000000000156
   Walther C, 2008, EUR J CARDIOV PREV R, V15, P107, DOI 10.1097/HJR.0b013e3282f29aa6
   Warren TY, 2010, MED SCI SPORT EXER, V42, P879, DOI 10.1249/MSS.0b013e3181c3aa7e
   WILSON PWF, 1994, AM J HYPERTENS, V7, pS7, DOI 10.1093/ajh/7.7.7S
   Wood D, 2001, AM HEART J, V141, pS49, DOI 10.1067/mhj.2001.109951
NR 81
TC 34
Z9 34
U1 8
U2 72
PU SPRINGER-VERLAG SINGAPORE PTE LTD
PI SINGAPORE
PA 152 BEACH ROAD, #21-01/04 GATEWAY EAST, SINGAPORE, 189721, SINGAPORE
SN 0065-2598
EI 2214-8019
BN 978-981-15-1792-1; 978-981-15-1791-4
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2020
VL 1228
BP 169
EP 179
DI 10.1007/978-981-15-1792-1_11
D2 10.1007/978-981-15-1792-1
PG 11
WC Medicine, Research & Experimental; Physiology; Sport Sciences
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Physiology; Sport Sciences
GA BQ5AS
UT WOS:000596720900011
PM 32342457
DA 2025-06-11
ER

PT J
AU do Moinho, TM
   Matos, SL
   Carvalho, CRO
AF do Moinho, Tais Menezes
   Matos, Sandro Leao
   Carvalho, Carla R. O.
TI A comprehensive review on phytochemicals for fatty liver: are they
   potential adjuvants?
SO JOURNAL OF MOLECULAR MEDICINE-JMM
LA English
DT Review
DE Fatty liver; NAFLD; Phytochemicals; Traditional medicine; Metabolic
   syndrome
ID ACTIVATED PROTEIN-KINASE; GINKGO-BILOBA EXTRACT; KOREAN RED GINSENG;
   FACTOR-KAPPA-B; INSULIN-RESISTANCE; HEPATIC STEATOSIS;
   UNCARIA-TOMENTOSA; OXIDATIVE STRESS; IN-VITRO; LIPID-METABOLISM
AB Non-alcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of metabolic syndrome and, as such, is associated with obesity. With the current and growing epidemic of obesity, NAFLD is already considered the most common liver disease in the world. Currently, there is no official treatment for the disease besides weight loss. Although there are a few synthetic drugs currently being studied, there is also an abundance of herbal products that could also be used for treatment. With the World Health Organization (WHO) traditional medicine strategy (2014-2023) in mind, this review aims to analyze the mechanisms of action of some of these herbal products, as well as evaluate toxicity and herb-drug interactions available in literature.
C1 [do Moinho, Tais Menezes; Matos, Sandro Leao; Carvalho, Carla R. O.] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508000 Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Institute Biomed Science, University Sao
   Paulo
RP Carvalho, CRO (corresponding author), Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508000 Sao Paulo, Brazil.
EM croc@icb.usp.br
RI Menezes do Moinho, Taís/CAI-0341-2022; Carvalho, Carla/H-6476-2018
OI Carvalho, Carla/0000-0001-5824-8656; Moinho, Tais/0000-0001-5996-8647;
   Leao, Sandro/0000-0002-4701-6769
FU Brazilian research agency: Fundacao de Amparo a Pesquisa do Estado de
   Sao Paulo [FAPESP - 2019/20464-8]; Brazilian research agency: Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico [CNPq -
   308093/2019-4, CNPq - 141743/2019-0]
FX This study was supported by grants from the Brazilian research agencies:
   Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP -
   2019/20464-8), and Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq - 308093/2019-4, and CNPq - 141743/2019-0).
CR Adeboye B, 2012, CARDIOVASC J AFR, V23, P512, DOI 10.5830/CVJA-2012-040
   Aguirre L, 2014, WORLD J GASTROENTERO, V20, P7366, DOI 10.3748/wjg.v20.i23.7366
   Al-Maamari Jamal Nasser Saleh, 2021, Journal of Basic and Clinical Physiology and Pharmacology, V32, P637, DOI 10.1515/jbcpp-2020-0423
   Apea-Bah FB, 2009, J MED PLANTS RES, V3, P736
   Araujo LCC, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-29044-y
   Asgary S, 2019, REV ENDOCR METAB DIS, V20, P173, DOI 10.1007/s11154-019-09494-z
   Basheer L, 2017, FOOD CHEM, V237, P895, DOI 10.1016/j.foodchem.2017.06.040
   Bone KM, 2008, MOL NUTR FOOD RES, V52, P764, DOI 10.1002/mnfr.200700098
   Browning JD, 2004, HEPATOLOGY, V40, P1387, DOI 10.1002/hep.20466
   Budzinski JW, 2000, PHYTOMEDICINE, V7, P273, DOI 10.1016/S0944-7113(00)80044-6
   Buzzetti E, 2016, METABOLISM, V65, P1038, DOI 10.1016/j.metabol.2015.12.012
   Cantó C, 2009, NATURE, V458, P1056, DOI 10.1038/nature07813
   Chalasani N, 2012, HEPATOLOGY, V55, P2005, DOI 10.1002/hep.25762
   Chan TYK, 1996, HUM EXP TOXICOL, V15, P5, DOI 10.1177/096032719601500102
   Chang CJ, 2014, FOOD CHEM TOXICOL, V65, P33, DOI 10.1016/j.fct.2013.11.048
   Chen X, 2005, PHARM RES-DORDR, V22, P892, DOI 10.1007/s11095-005-4584-1
   Choi SY, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122963
   Chow HHS, 2010, CANCER PREV RES, V3, P1168, DOI 10.1158/1940-6207.CAPR-09-0155
   Chun YJ, 1999, BIOCHEM BIOPH RES CO, V262, P20, DOI 10.1006/bbrc.1999.1152
   Cravotto G, 2010, J CLIN PHARM THER, V35, P11, DOI 10.1111/j.1365-2710.2009.01096.x
   Daston L, 2014, ISIS, V105, P579, DOI 10.1086/678173
   MIRANDA-HENRIQUES Mônica Souza de, 2014, Arq. Gastroenterol., V51, P255, DOI 10.1590/S0004-28032014000300016
   Di Costanzo A, 2019, MOLECULES, V24, DOI 10.3390/molecules24112155
   Ding SB, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0183541
   Domingues A, 2011, J ETHNOPHARMACOL, V137, P635, DOI 10.1016/j.jep.2011.06.021
   Dong GZ, 2014, EUR J PHARMACOL, V740, P634, DOI 10.1016/j.ejphar.2014.06.017
   Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI23621
   Elgebaly A, 2017, J GASTROINTEST LIVER, V26, P59, DOI 10.15403/jgld.2014.1121.261.ely
   Faghihzadeh F, 2015, J RES MED SCI, V20, P797, DOI 10.4103/1735-1995.168405
   Fang YL, 2018, WORLD J GASTROENTERO, V24, P2974, DOI 10.3748/wjg.v24.i27.2974
   Federico A, 2017, MOLECULES, V22, DOI 10.3390/molecules22020191
   Frühbeck G, 2014, NUTR RES REV, V27, P63, DOI 10.1017/S095442241400002X
   Ghanbari M, 2021, INT IMMUNOPHARMACOL, V96, DOI 10.1016/j.intimp.2021.107765
   Ghavami A, 2020, COMPLEMENT THER CLIN, V39, DOI 10.1016/j.ctcp.2020.101173
   Gnoni GV, 2009, EUR J CLIN INVEST, V39, P211, DOI 10.1111/j.1365-2362.2008.02077.x
   Gori M, 2021, BIOTECHNOL BIOENG, V118, P142, DOI 10.1002/bit.27557
   Gu DS, 2021, LIFE SCI, V267, DOI 10.1016/j.lfs.2020.118986
   Guilherme A, 2008, NAT REV MOL CELL BIO, V9, P367, DOI 10.1038/nrm2391
   Guo Y, 2015, J NUTR BIOCHEM, V26, P201, DOI 10.1016/j.jnutbio.2014.10.008
   Hadi A, 2018, COMPLEMENT THER MED, V41, P311, DOI 10.1016/j.ctim.2018.08.010
   Hernandez-Garcia D, 2019, J ETHNOPHARMACOL, V243, DOI 10.1016/j.jep.2019.112090
   Hong Ji Taek, 2021, J Ginseng Res, V45, P316, DOI 10.1016/j.jgr.2020.07.004
   Hong M, 2016, J GINSENG RES, V40, P203, DOI 10.1016/j.jgr.2015.07.006
   Hong SH, 2013, FOOD CHEM TOXICOL, V55, P586, DOI 10.1016/j.fct.2013.01.022
   Hosseini H, 2020, INT J BIOCHEM CELL B, V119, DOI 10.1016/j.biocel.2019.105667
   Hosseinikia M, 2020, NUTR FOOD SCI, V50, P1279, DOI 10.1108/NFS-10-2019-0321
   Hsiang CY, 2015, PHYTOMEDICINE, V22, P768, DOI 10.1016/j.phymed.2015.05.053
   Huang HH, 2020, NUTR REV, V78, P615, DOI 10.1093/nutrit/nuz071
   Huang Q, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18051063
   Huang Y, 2020, PHYSIOL MEAS, V41, DOI 10.1088/1361-6579/ab9feb
   Hutchinson C, 2010, EUR J CLIN NUTR, V64, P1239, DOI 10.1038/ejcn.2010.136
   Hyrsova L, 2019, TOXICOL LETT, V300, P81, DOI 10.1016/j.toxlet.2018.10.028
   Jakubczyk K, 2020, NUTRIENTS, V12, DOI 10.3390/nu12082435
   Jeong H, 2018, AM J CHINESE MED, V46, P1581, DOI 10.1142/S0192415X18500817
   Jeong HS, 2017, BIOMED PHARMACOTHER, V88, P625, DOI 10.1016/j.biopha.2017.01.114
   Jung CH, 2013, PHYTOTHER RES, V27, P139, DOI 10.1002/ptr.4687
   Kahraman C, 2020, Med Toxicol, P1
   Kalopitas G, 2021, NUTRITION, V83, DOI 10.1016/j.nut.2020.111092
   Kim CS, 2015, NUTR METAB, V12, DOI 10.1186/s12986-015-0030-5
   Kim JH, 2010, J MED FOOD, V13, P1133, DOI 10.1089/jmf.2010.1128
   Kim J, 2011, NAT CELL BIOL, V13, P132, DOI 10.1038/ncb2152
   Kim MG, 2016, BRIT J CLIN PHARMACO, V82, P1580, DOI 10.1111/bcp.13080
   Kim M, 2012, INT J MOL MED, V30, P473, DOI 10.3892/ijmm.2012.1029
   Kobori M, 2011, MOL NUTR FOOD RES, V55, P530, DOI 10.1002/mnfr.201000392
   Lama S, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-40105-8
   Lamm S, 2001, PHYTOMEDICINE, V8, P267, DOI 10.1078/0944-7113-00046
   Lee SB, 2016, J PHARM PHARMACOL, V68, P119, DOI 10.1111/jphp.12487
   Lemamsha H, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/8531360
   Li L, 2014, FOOD CHEM TOXICOL, V63, P166, DOI 10.1016/j.fct.2013.08.036
   Li L, 2021, J INFLAMM RES, V14, P1959, DOI 10.2147/JIR.S302934
   Li XH, 2007, NATURE, V447, P1012, DOI 10.1038/nature05861
   Li XL, 2013, BIOMED REP, V1, P71, DOI 10.3892/br.2012.27
   Li Y, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030167
   Li Y, 2011, CELL METAB, V13, P376, DOI 10.1016/j.cmet.2011.03.009
   Li YY, 2019, CHIN J NAT MEDICINES, V17, P672, DOI 10.1016/S1875-5364(19)30081-0
   Liang WY, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.622841
   Liu L., 2015, Biomed Res Int, V2015, P607531, DOI DOI 10.1155/2015/607531
   Liu WS, 2016, CELL MOL LIFE SCI, V73, P1969, DOI 10.1007/s00018-016-2161-x
   Loomba R, 2013, NAT REV GASTRO HEPAT, V10, P686, DOI 10.1038/nrgastro.2013.171
   Lüde S, 2016, PHYTOTHER RES, V30, P988, DOI 10.1002/ptr.5604
   Lynch N, 2007, COMPLEMENT THER MED, V15, P84, DOI 10.1016/j.ctim.2006.06.007
   Malati CY, 2012, J CLIN PHARMACOL, V52, P932, DOI 10.1177/0091270011407194
   Manne V, 2018, CLIN LIVER DIS, V22, P23, DOI 10.1016/j.cld.2017.08.007
   Maria AS, 1997, J ETHNOPHARMACOL, V57, P183, DOI 10.1016/S0378-8741(97)00067-6
   Mauer J, 2014, NAT IMMUNOL, V15, P423, DOI 10.1038/ni.2865
   Mohos V, 2020, NUTRIENTS, V12, DOI 10.3390/nu12082306
   Montserrat-de la Paz S, 2015, J ETHNOPHARMACOL, V170, P128, DOI 10.1016/j.jep.2015.05.002
   Moore MP, 2020, OBESITY, V28, P1843, DOI 10.1002/oby.22964
   Muller G, 1997, J BIOL CHEM, V272, P10585, DOI 10.1074/jbc.272.16.10585
   Mundi MS, 2020, NUTR CLIN PRACT, V35, P72, DOI 10.1002/ncp.10449
   Murphy AJ, 2016, CELL METAB, V23, P155, DOI 10.1016/j.cmet.2015.09.024
   Ni XJ, 2016, AM J TRANSL RES, V8, P1073
   Ortega-Prieto P, 2019, FRONT GENET, V10, DOI 10.3389/fgene.2019.00472
   Ou Q, 2018, DIGEST DIS SCI, V63, P3398, DOI 10.1007/s10620-018-5268-0
   Ou QW, 2020, INT J FOOD SCI NUTR, V71, P152, DOI 10.1080/09637486.2019.1627515
   Park M, 2020, J GINSENG RES, V44, P350, DOI 10.1016/j.jgr.2019.09.004
   Petersen MC, 2018, PHYSIOL REV, V98, P2133, DOI 10.1152/physrev.00063.2017
   Porras D, 2017, FREE RADICAL BIO MED, V102, P188, DOI 10.1016/j.freeradbiomed.2016.11.037
   Purushotham A, 2009, CELL METAB, V9, P327, DOI 10.1016/j.cmet.2009.02.006
   Qin GH, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19124126
   Rada P, 2020, CELL DEATH DIS, V11, DOI 10.1038/s41419-020-03003-w
   Ravikumar B, 2004, NAT GENET, V36, P585, DOI 10.1038/ng1362
   Rodgers JT, 2005, NATURE, V434, P113, DOI 10.1038/nature03354
   Rojas-Duran R, 2012, J ETHNOPHARMACOL, V143, P801, DOI 10.1016/j.jep.2012.07.015
   Ruilope LM, 2018, HIPERTEN RIESGO VASC, V35, P70, DOI 10.1016/j.hipert.2017.12.004
   Sahebkar A, 2017, CRIT REV FOOD SCI, V57, P666, DOI 10.1080/10408398.2014.948609
   Sahin E, 2020, J FOOD BIOCHEM, V44, DOI 10.1111/jfbc.13194
   Salamone F, 2012, TRANSL RES, V159, P477, DOI 10.1016/j.trsl.2011.12.003
   Salamone F, 2012, DIGEST LIVER DIS, V44, P334, DOI 10.1016/j.dld.2011.11.010
   Salomone F, 2017, NUTRIENTS, V9, DOI 10.3390/nu9101086
   Sandoval M, 2000, FREE RADICAL BIO MED, V29, P71, DOI 10.1016/S0891-5849(00)00327-0
   Sengupta S, 2010, NATURE, V468, P1100, DOI 10.1038/nature09584
   Shabalala SC, 2020, BIOMED PHARMACOTHER, V131, DOI 10.1016/j.biopha.2020.110785
   Sheng Y, 2001, PHYTOMEDICINE, V8, P275, DOI 10.1078/0944-7113-00045
   Shishtar E, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0107391
   Soleimani V, 2019, PHYTOTHER RES, V33, P1627, DOI 10.1002/ptr.6361
   Song ZY, 2007, BASIC CLIN PHARMACOL, V101, P262, DOI 10.1111/j.1742-7843.2007.00116.x
   Springer M, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010143
   Stephens JM, 1997, J BIOL CHEM, V272, P971, DOI 10.1074/jbc.272.2.971
   Steyn NP, 2014, ANN NY ACAD SCI, V1311, P88, DOI 10.1111/nyas.12433
   Sun RB, 2020, BIOMED PHARMACOTHER, V123, DOI 10.1016/j.biopha.2019.109721
   Tabrizi R, 2020, CRIT REV FOOD SCI, V60, P375, DOI 10.1080/10408398.2018.1529654
   Tabrizi R, 2020, CRIT REV FOOD SCI, V60, P1855, DOI 10.1080/10408398.2019.1604491
   Tian YL, 2016, MOL CELL BIOCHEM, V422, P75, DOI 10.1007/s11010-016-2807-x
   Toselli S, 2014, EUR J PUBLIC HEALTH, V24, P31, DOI 10.1093/eurpub/cku103
   Trayhurn P, 2013, PHYSIOL REV, V93, P1, DOI 10.1152/physrev.00017.2012
   Vaes LPJ, 2000, ANN PHARMACOTHER, V34, P1478, DOI 10.1345/aph.10031
   van der Merwe MT, 2006, OBES REV, V7, P315, DOI 10.1111/j.1467-789X.2006.00237.x
   Vidyashankar S, 2013, TOXICOL IN VITRO, V27, P945, DOI 10.1016/j.tiv.2013.01.014
   Voroneanu L, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/5147468
   Walker R, 2004, TOXICOL LETT, V149, P187, DOI 10.1016/j.toxlet.2004.03.001
   Wallenius V, 2002, NAT MED, V8, P75, DOI 10.1038/nm0102-75
   Wang F, 2021, NUTRIENTS, V13, DOI 10.3390/nu13030856
   Wang GL, 2009, BIOCHEM BIOPH RES CO, V380, P644, DOI 10.1016/j.bbrc.2009.01.163
   Wang SD, 2012, J DIGEST DIS, V13, P525, DOI 10.1111/j.1751-2980.2012.00627.x
   Wang ZW, 2013, FITOTERAPIA, V90, P30, DOI 10.1016/j.fitote.2013.07.005
   Wanwimolruk S, 2014, EXCLI J, V13, P347
   Wei T, 2014, J BIOMED SCI, V21, DOI 10.1186/s12929-014-0087-x
   Xiao F., 2020, Medicine, V99
   Xu XM, 2021, BIOMED PHARMACOTHER, V133, DOI 10.1016/j.biopha.2020.110984
   Xu X, 2013, SEMIN LIVER DIS, V33, P301, DOI 10.1055/s-0033-1358523
   Xu YS, 2018, BIOL PHARM BULL, V41, P1638, DOI 10.1248/bpb.b18-00132
   Yadav A, 2013, CLIN CHIM ACTA, V417, P80, DOI 10.1016/j.cca.2012.12.007
   Yamauchi T, 2003, NATURE, V423, P762, DOI 10.1038/nature01705
   Yan ZG, 2015, INT J BIOL MACROMOL, V80, P573, DOI 10.1016/j.ijbiomac.2015.05.054
   Yang H, 2019, PHYTOTHER RES, V33, P3140, DOI 10.1002/ptr.6486
   YANG L, 2019, EVID-BASED COMPL ALT
   Yang YW, 2020, TOXICOLOGY, V445, DOI 10.1016/j.tox.2020.152599
   Yao JY, 2013, BRAZ J MED BIOL RES, V46, P270, DOI 10.1590/1414-431X20122551
   Yeh MM, 2014, GASTROENTEROLOGY, V147, P754, DOI 10.1053/j.gastro.2014.07.056
   You TJ, 2005, AM J PHYSIOL-ENDOC M, V288, pE741, DOI 10.1152/ajpendo.00419.2004
   Xu Y, 2021, HEPATOL INT, V15, P350, DOI 10.1007/s12072-021-10138-1
   Zang MW, 2006, DIABETES, V55, P2180, DOI 10.2337/db05-1188
   Zhang BL, 2018, FASEB J, V32, P757, DOI 10.1096/fj.201700602R
   Zhang HC, 2017, SCI REP-UK, V7, DOI [10.1038/srep43163, 10.1038/srep40819, 10.1038/srep39911]
   Zhang Q, 2015, J ETHNOPHARMACOL, V173, P48, DOI 10.1016/j.jep.2015.06.011
   Zhang YX, 2013, INT IMMUNOPHARMACOL, V17, P714, DOI 10.1016/j.intimp.2013.08.019
   Zhong S, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000009061
   Zhu XH, 2018, FOOD CHEM TOXICOL, V114, P52, DOI 10.1016/j.fct.2018.02.019
   Ziaei R, 2020, COMPLEMENT THER MED, V48, DOI 10.1016/j.ctim.2019.102239
NR 160
TC 6
Z9 6
U1 2
U2 17
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0946-2716
EI 1432-1440
J9 J MOL MED
JI J. Mol. Med.
PD MAR
PY 2022
VL 100
IS 3
BP 411
EP 425
DI 10.1007/s00109-021-02170-3
EA JAN 2022
PG 15
WC Genetics & Heredity; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Research & Experimental Medicine
GA YY9ZA
UT WOS:000739786500001
PM 34993581
DA 2025-06-11
ER

PT J
AU Guest, PC
   Chan, MK
   Gottschalk, MG
   Bahn, S
AF Guest, Paul C.
   Chan, Man K.
   Gottschalk, Michael G.
   Bahn, Sabine
TI The use of proteomic biomarkers for improved diagnosis and
   stratification of schizophrenia patients
SO BIOMARKERS IN MEDICINE
LA English
DT Review
DE brain; comorbidities; inflammation; metabolic syndrome; personalized
   medicine; proteomics; schizophrenia; serum
ID PITUITARY-ADRENAL AXIS; PLACEBO-CONTROLLED TRIAL; DRUG-NAIVE PATIENTS;
   OXIDATIVE STRESS MARKERS; INSULIN-RESISTANCE; DOUBLE-BLIND;
   PSYCHIATRIC-DISORDERS; ALZHEIMERS-DISEASE; METABOLIC SYNDROME;
   SUPEROXIDE-DISMUTASE
AB Schizophrenia is characterized by a wide spectrum of clinical manifestations, including strong effects on mood and behavior. Patients can also suffer from serious comorbidities including immune system or metabolic abnormalities. Recent advances using proteomic profiling approaches have increased our understanding of these molecular effects and have laid the groundwork for unraveling the heterogeneity of this broadly defined disease. These findings could lead to improved diagnosis and stratification of patients through identification of biochemically different disease subtypes and personalized medicine approaches. The inclusion of molecular signatures in psychiatry will be an important leap forward in providing more effective treatment of patients suffering from this debilitating disorder.
C1 [Guest, Paul C.; Chan, Man K.; Gottschalk, Michael G.; Bahn, Sabine] Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge, England.
   [Bahn, Sabine] Erasmus MC, Dept Neurosci, Rotterdam, Netherlands.
C3 University of Cambridge; Erasmus University Rotterdam; Erasmus MC
RP Bahn, S (corresponding author), Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge, England.
EM sb209@cam.ac.uk
RI Gottschalk, Michael/AAZ-8925-2020
OI Chan, Man/0000-0002-4866-5170; guest, paul/0000-0002-5030-7137;
   Gottschalk, Michael/0000-0002-2386-3701
FU Stanley Medical Research Institute; Dutch Fund for Economic Structure
   Reinforcement (FES) [0908]; European Union [223427]
FX This work was supported by grants from the Stanley Medical Research
   Institute, the Dutch Fund for Economic Structure Reinforcement (FES)
   under grant agreement number 0908 (NeuroBasic PharmaPhenomics project),
   and the European Union FP7 SchizDX research programme (grant reference
   223427). PC Guest and S Bahn are consultants for Myriad-RBM, although
   this does not interfere with ownership regarding data sharing or
   materials. The authors have no other relevant affiliations or financial
   involvement with any organization or entity with a financial interest in
   or financial conflict with the subject matter or materials discussed in
   the manuscript apart from those disclosed.
CR Akhondzadeh S, 2007, SCHIZOPHR RES, V90, P179, DOI 10.1016/j.schres.2006.11.016
   Albus M, 2012, PHARMACOPSYCHIATRY, V45, pS31, DOI 10.1055/s-0032-1308968
   [Anonymous], 2000, DIAGN STAT MAN MENT
   Arranz B, 2004, J CLIN PSYCHIAT, V65, P1335, DOI 10.4088/JCP.v65n1007
   Arranz MJ, 2000, LANCET, V355, P1615, DOI 10.1016/S0140-6736(00)02221-2
   Bahtiyar Gul, 2007, Endocr Pract, V13, P601
   Bartolomucci A, 2010, NEUROSCIENCE, V170, P289, DOI 10.1016/j.neuroscience.2010.06.057
   Bello NT, 2006, PHYSIOL BEHAV, V88, P138, DOI 10.1016/j.physbeh.2006.03.027
   Ben-Jonathan N, 2006, TRENDS ENDOCRIN MET, V17, P110, DOI 10.1016/j.tem.2006.02.005
   Carlino D, 2011, J PSYCHIATR RES, V45, P273, DOI 10.1016/j.jpsychires.2010.06.012
   Chakos M, 2001, AM J PSYCHIAT, V158, P518, DOI 10.1176/appi.ajp.158.4.518
   Chan MK, 2011, MOL PSYCHIATR, V16, P1189, DOI 10.1038/mp.2010.100
   Chandler Mark, 2003, Drug Discov Today, V8, P874
   Cohn TA, 2006, CAN J PSYCHIAT, V51, P382, DOI 10.1177/070674370605100608
   Convit A, 2005, NEUROBIOL AGING, V26, pS31, DOI 10.1016/j.neurobiolaging.2005.09.018
   Corcoran C, 2003, SCHIZOPHRENIA BULL, V29, P671, DOI 10.1093/oxfordjournals.schbul.a007038
   Corcoran CM, 2012, SCHIZOPHR RES, V135, P170, DOI 10.1016/j.schres.2011.11.035
   Craft S, 2007, CURR ALZHEIMER RES, V4, P147, DOI 10.2174/156720507780362137
   Dimitriadis GD, 2001, EXP CLIN ENDOCR DIAB, V109, pS225, DOI 10.1055/s-2001-18584
   Domenici E, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009166
   Eaton WW, 2006, AM J PSYCHIAT, V163, P521, DOI 10.1176/appi.ajp.163.3.521
   English JA, 2011, BIOL PSYCHIAT, V69, P163, DOI 10.1016/j.biopsych.2010.06.031
   English JA, 2009, PROTEOMICS, V9, P3368, DOI 10.1002/pmic.200900015
   FESSEL W. JEFFREY, 1960, CALIFORNIA MED, V92, P266
   Fleming CE, 2009, PROG NEUROBIOL, V89, P266, DOI 10.1016/j.pneurobio.2009.07.007
   Föcking M, 2011, ARCH GEN PSYCHIAT, V68, P477, DOI 10.1001/archgenpsychiatry.2011.43
   Freudenreich O, 2010, PSYCHIAT RES, V176, P99, DOI 10.1016/j.psychres.2008.11.007
   GARCIA GE, 1994, PEPTIDES, V15, P195, DOI 10.1016/0196-9781(94)90190-2
   Gawryluk JW, 2011, INT J NEUROPSYCHOPH, V14, P123, DOI 10.1017/S1461145710000805
   Goodsaid F, 2007, ENVIRON MOL MUTAGEN, V48, P354, DOI 10.1002/em.20294
   Goodsaid F, 2006, PHARMACOGENOMICS, V7, P773, DOI 10.2217/14622416.7.5.773
   Gorobets LN, 2010, ZH NEVROL PSIKHIATR, V110, P17
   Guest PC, 2010, MOL PSYCHIATR, V15, P118, DOI 10.1038/mp.2009.81
   Guest PC, 2011, PSYCHONEUROENDOCRINO, V36, P1092, DOI 10.1016/j.psyneuen.2010.12.018
   Hafner Heinz, 1998, Kaohsiung Journal of Medical Sciences, V14, P413
   Handwerger K, 2009, HARVARD REV PSYCHIAT, V17, P184, DOI 10.1080/10673220902996775
   Hasnain M, 2010, CURR DIABETES REP, V10, P209, DOI 10.1007/s11892-010-0112-8
   Helle KB, 2007, CELL MOL LIFE SCI, V64, P2863, DOI 10.1007/s00018-007-7254-0
   Herberth M, 2011, MOL PSYCHIATR, V16, P848, DOI 10.1038/mp.2010.71
   Herken H, 2001, MOL PSYCHIATR, V6, P66, DOI 10.1038/sj.mp.4000789
   HUTTON JC, 1994, DIABETOLOGIA, V37, pS48, DOI 10.1007/BF00400826
   Izmailov R, 2011, INT REV NEUROBIOL, V101, P279, DOI 10.1016/B978-0-12-387718-5.00011-0
   Jaros JAJ, 2012, J PROTEOMICS, V76, P43, DOI 10.1016/j.jprot.2012.05.027
   Jin H, 2010, J CLIN PSYCHIAT, V71, P1273, DOI 10.4088/JCP.09m05414yel
   Krishnamurthy D, 2013, WORLD J BIOL PSYCHIA, V14, P478, DOI 10.3109/15622975.2011.601759
   LABORIT H, 1976, Resuscitation, V5, P19, DOI 10.1016/0300-9572(76)90017-4
   Landreth G, 2008, NEUROTHERAPEUTICS, V5, P481, DOI 10.1016/j.nurt.2008.05.003
   Lara DR, 2001, J PSYCHIATR RES, V35, P11, DOI 10.1016/S0022-3956(01)00003-6
   Laughren TP, 2010, J CLIN PSYCHIAT, V71, P1196, DOI 10.4088/JCP.10m06262gry
   Levin Y, 2010, MOL PSYCHIATR, V15, P1088, DOI 10.1038/mp.2009.54
   Lovatt A, 2010, J NERV MENT DIS, V198, P813, DOI 10.1097/NMD.0b013e3181f97c3d
   Martins-de-Souza D, 2011, ANTIOXID REDOX SIGN, V15, P2067, DOI 10.1089/ars.2010.3459
   Martins-De-Souza D, 2009, EUR ARCH PSY CLIN N, V259, P151, DOI 10.1007/s00406-008-0847-2
   Mastorakos G, 2004, NUTR NEUROSCI, V7, P271, DOI 10.1080/10284150400020516
   Meltzer H, 2001, NEUROPSYCHOPHARMACOL, V24, P278, DOI 10.1016/S0893-133X(00)00201-3
   MERRILL JE, 1992, DEV NEUROSCI-BASEL, V14, P1, DOI 10.1159/000111642
   Meyer U, 2009, SCHIZOPHRENIA BULL, V35, P959, DOI 10.1093/schbul/sbn022
   Miller BJ, 2011, BIOL PSYCHIAT, V70, P663, DOI 10.1016/j.biopsych.2011.04.013
   Müller N, 2006, NEUROTOX RES, V10, P131
   Müller N, 2010, SCHIZOPHR RES, V121, P118, DOI 10.1016/j.schres.2010.04.015
   Müller N, 2004, PHARMACOPSYCHIATRY, V37, P266, DOI 10.1055/s-2004-832682
   Nachshoni T, 2005, SCHIZOPHR RES, V79, P251, DOI 10.1016/j.schres.2005.07.029
   Newall H, 2012, INT CLIN PSYCHOPHARM, V27, P69, DOI 10.1097/YIC.0b013e32834d0a5b
   Nilsson BM, 2006, PROSTAG LEUKOTR ESS, V74, P339, DOI 10.1016/j.plefa.2006.02.002
   O'Connell K, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-146
   O'Malley D, 2003, NEUROPHARMACOLOGY, V44, P855, DOI 10.1016/S0028-3908(03)00081-9
   Offord S, 2013, ADV THER, V30, P286, DOI 10.1007/s12325-013-0016-5
   Owens J, 2006, NAT REV DRUG DISCOV, V5, P271, DOI 10.1038/nrd2015
   Pasquali R, 2006, ANN NY ACAD SCI, V1083, P111, DOI 10.1196/annals.1367.009
   Pedrini M, 2012, J PSYCHIATR RES, V46, P819, DOI 10.1016/j.jpsychires.2012.03.019
   Pennington K, 2008, MOL PSYCHIATR, V13, P1102, DOI 10.1038/sj.mp.4002098
   Phillips LJ, 2006, AUST NZ J PSYCHIAT, V40, P725, DOI 10.1111/j.1440-1614.2006.01877.x
   Pramyothin P, 2010, CURR OPIN ENDOCRINOL, V17, P460, DOI 10.1097/MED.0b013e32833de61c
   Ranjekar PK, 2003, PSYCHIAT RES, V121, P109, DOI 10.1016/S0165-1781(03)00220-8
   Reagan LP, 2007, CURR OPIN PHARMACOL, V7, P633, DOI 10.1016/j.coph.2007.10.012
   REDDY R, 1991, BIOL PSYCHIAT, V30, P409, DOI 10.1016/0006-3223(91)90298-Z
   Rice DP, 1999, J CLIN PSYCHIAT, V60, P4
   Ryan MCM, 2003, AM J PSYCHIAT, V160, P284, DOI 10.1176/appi.ajp.160.2.284
   SARTORIUS N, 1995, AM J PSYCHIAT, V152, P1427
   Sato T, 2011, NEUROBIOL AGING, V32, P1626, DOI 10.1016/j.neurobiolaging.2009.10.009
   Schwarz E, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.3
   Schwarz E, 2012, MOL PSYCHIATR, V17, P494, DOI 10.1038/mp.2011.42
   Schwarz E, 2010, BIOMARK INSIGHTS, V5, P39
   Shrivastava Amresh, 2012, Innov Clin Neurosci, V9, P17
   SIROTA P, 1993, BIOL PSYCHIAT, V33, P450, DOI 10.1016/0006-3223(93)90173-B
   SMITH R, 1991, BAILLIERE CLIN ENDOC, V5, P167, DOI 10.1016/S0950-351X(05)80102-8
   Söderlund J, 2009, MOL PSYCHIATR, V14, P1069, DOI 10.1038/mp.2009.52
   Solas M, 2010, NEUROPSYCHOPHARMACOL, V35, P1664, DOI 10.1038/npp.2010.13
   Sommer IE, 2012, J CLIN PSYCHIAT, V73, P414, DOI 10.4088/JCP.10r06823
   SPATHSCHWALBE E, 1994, J CLIN ENDOCR METAB, V79, P1212, DOI 10.1210/jc.79.4.1212
   Spelman LM, 2007, DIABETIC MED, V24, P481, DOI 10.1111/j.1464-5491.2007.02092.x
   Steiner J, 2011, CLIN CHEM LAB MED, V49, P409, DOI 10.1515/CCLM.2011.083
   Stephan KE, 2009, SCHIZOPHRENIA BULL, V35, P509, DOI 10.1093/schbul/sbn176
   Straub RH, 2011, CLIN EXP RHEUMATOL, V29, pS23
   Taguchi A, 2007, SCIENCE, V317, P369, DOI 10.1126/science.1142179
   TANNENBAUM GS, 1976, ENDOCRINOLOGY, V99, P720, DOI 10.1210/endo-99-3-720
   Unlu M, 1997, ELECTROPHORESIS, V18, P2071, DOI 10.1002/elps.1150181133
   Usall J, 2011, J CLIN PSYCHIAT, V72, P1552, DOI 10.4088/JCP.10m06610
   van Nimwegen LJM, 2008, J CLIN ENDOCR METAB, V93, P572, DOI 10.1210/jc.2007-1167
   van Os J, 2009, LANCET, V374, P635, DOI [10.1016/S0140-6736(09)60995-8, 10.1016/S0140-6736(15)01121-6]
   Wang L, 2010, J PROTEOME RES, V9, P521, DOI 10.1021/pr900867x
   Ward Alex, 2013, P T, V38, P109
   Watson S, 2004, BRIT J PSYCHIAT, V184, P496, DOI 10.1192/bjp.184.6.496
   Wilkins MR, 1996, BIOTECHNOL GENET ENG, V13, P19, DOI 10.1080/02648725.1996.10647923
   Wolters DA, 2001, ANAL CHEM, V73, P5683, DOI 10.1021/ac010617e
   Wong EHF, 2010, INT J NEUROPSYCHOPH, V13, P1269, DOI 10.1017/S1461145710000866
   Wu ZW, 2012, PROG NEURO-PSYCHOPH, V36, P34, DOI 10.1016/j.pnpbp.2011.08.018
   Yang YF, 2006, ANAL CHEM, V78, P3571, DOI 10.1021/ac051916x
   Yelmo-Cruz S, 2013, PSYCHIAT CLIN NEUROS, V67, P67, DOI 10.1111/pcn.12024
   Zhang JP, 2011, EXPERT OPIN DRUG MET, V7, P9, DOI 10.1517/17425255.2011.532787
   Zhang M, 2010, SCI CHINA LIFE SCI, V53, P112, DOI 10.1007/s11427-010-0013-8
   Zhang XY, 2005, NEUROPSYCHOPHARMACOL, V30, P1532, DOI 10.1038/sj.npp.1300756
   Zhang XY, 2003, PSYCHIAT RES, V117, P85, DOI 10.1016/S0165-1781(02)00303-7
NR 114
TC 29
Z9 30
U1 0
U2 22
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1752-0363
EI 1752-0371
J9 BIOMARK MED
JI Biomark. Med.
PD JAN
PY 2014
VL 8
IS 1
BP 15
EP 27
DI 10.2217/bmm.13.83
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AI9BF
UT WOS:000337220700005
PM 24325222
DA 2025-06-11
ER

PT J
AU Jin, Y
   Heo, KS
AF Jin, Yujin
   Heo, Kyung-Sun
TI Experimental model and novel therapeutic targets for non-alcoholic fatty
   liver disease development
SO KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
LA English
DT Review
DE Drug targeting; Hepatitis; Metabolic syndrome; Non-alcoholic fatty liver
   disease
ID LIPID-ACCUMULATION; MOUSE MODEL; ER STRESS; INFLAMMATION; APOPTOSIS;
   ACTIVATION; FIBROSIS; PATHWAY; CANCER; STEATOHEPATITIS
AB Non-alcoholic fatty liver disease (NAFLD) is a complex disorder characterized by the accumulation of fat in the liver in the absence of excessive alcohol consumption. It is one of the most common liver diseases worldwide, affecting approximately 25% of the global population. It is closely associated with obesity, type 2 diabetes, and metabolic syndrome. Moreover, NAFLD can progress to non-alcoholic steatohepatitis, which can cause liver cirrhosis, liver failure, and hepatocellular carcinoma. Currently, there are no approved drugs for the treatment of NAFLD. Therefore, the development of effective drugs is essential for NAFLD treatment. In this article, we discuss the experimental models and novel therapeutic targets for NAFLD. Additionally, we propose new strategies for the development of drugs for NAFLD.
C1 [Heo, Kyung-Sun] Chungnam Natl Univ, Coll Pharm, Daejeon 34134, South Korea.
   Chungnam Natl Univ, Inst Drug Res & Dev, Daejeon 34134, South Korea.
C3 Chungnam National University; Chungnam National University
RP Heo, KS (corresponding author), Chungnam Natl Univ, Coll Pharm, Daejeon 34134, South Korea.
EM kheo@cnu.ac.kr
RI Jin, Yujin/MEP-9121-2025; HEO, KYUNGSUN/LPQ-6041-2024
FU National Research Foundation of Korea (NRF) - Ministry of Science, ICT
   and Future Planning [2019R1C1C100733112]
FX This research was supported by the National Research Foundation of Korea
   (NRF) funded by the Ministry of Science, ICT and Future Planning
   (2019R1C1C100733112).
CR Abdel-Bakky MS, 2021, KOREAN J PHYSIOL PHA, V25, P385, DOI 10.4196/kjpp.2021.25.5.385
   Ala M, 2023, OBES REV, V24, DOI 10.1111/obr.13563
   Bai JL, 2019, DIABETES, V68, P1099, DOI 10.2337/dbi18-0052
   Barbier-Torres L, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-16991-2
   Bashiardes S, 2016, MOL METAB, V5, P782, DOI 10.1016/j.molmet.2016.06.003
   Behary J, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-020-20422-7
   Chang XM, 2021, KOREAN J PHYSIOL PHA, V25, P425, DOI 10.4196/kjpp.2021.25.5.425
   Chen ZG, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0572-9
   Choudhury M, 2011, MOL CELL ENDOCRINOL, V331, P102, DOI 10.1016/j.mce.2010.08.014
   Chyau CC, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21010360
   Daniel PV, 2021, J BIOL CHEM, V296, DOI 10.1016/j.jbc.2021.100714
   Deng MJ, 2020, J ENDOCRINOL, V245, P425, DOI 10.1530/JOE-20-0018
   Diniz TA, 2021, LIFE SCI, V266, DOI 10.1016/j.lfs.2020.118868
   Feng M, 2021, J ETHNOPHARMACOL, V277, DOI 10.1016/j.jep.2021.114251
   Gaul S, 2021, J HEPATOL, V74, P156, DOI 10.1016/j.jhep.2020.07.041
   Giugliano D, 2021, CARDIOVASC DIABETOL, V20, DOI 10.1186/s12933-021-01366-8
   Gong GJ, 2021, KOREAN J PHYSIOL PHA, V25, P403, DOI 10.4196/kjpp.2021.25.5.403
   Gray ME, 2022, NUTRIENTS, V14, DOI 10.3390/nu14040854
   GREENAN J, 1984, ACTA ANAESTH SCAND, V28, P182, DOI 10.1111/j.1399-6576.1984.tb02037.x
   Hardie DG, 2007, NAT REV MOL CELL BIO, V8, P774, DOI 10.1038/nrm2249
   Phung HH, 2022, ARCH PHARM RES, V45, P761, DOI 10.1007/s12272-022-01410-5
   Hou X, 2021, HEPATOLOGY, V74, P116, DOI 10.1002/hep.31658
   Hsu MC, 2021, J FOOD DRUG ANAL, V29, P240, DOI 10.38212/2224-6614.3269
   Hu YY, 2022, FRONT PHYSIOL, V13, DOI 10.3389/fphys.2022.803445
   Huang SL, 2021, METABOLISM, V120, DOI 10.1016/j.metabol.2021.154797
   Hundertmark J, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.02418
   Im SS, 2011, J BIOL CHEM, V286, P1157, DOI 10.1074/jbc.M110.157875
   Im YR, 2021, HEPATOLOGY, V74, P1884, DOI 10.1002/hep.31897
   Ioannou GN, 2021, J HEPATOL, V75, P1476, DOI 10.1016/j.jhep.2021.08.012
   Jaine R, 2018, LUNG CANCER, V124, P233, DOI 10.1016/j.lungcan.2018.08.004
   Jeon H, 2021, ARCH PHARM RES, V44, P702, DOI 10.1007/s12272-021-01345-3
   Jin YJ, 2023, LIFE SCI, V321, DOI 10.1016/j.lfs.2023.121607
   Jin YJ, 2022, LIFE SCI, V309, DOI 10.1016/j.lfs.2022.120973
   Jin YJ, 2022, ARCH PHARM RES, V45, P174, DOI 10.1007/s12272-022-01377-3
   Jin Y, 2020, ARCH PHARM RES, V43, P773, DOI [10.1007/s12272-020-01265-8, 10.1007/s12272-020-01255-w]
   Kanda T, 2018, WORLD J GASTROENTERO, V24, P2661, DOI 10.3748/wjg.v24.i25.2661
   Khan MS, 2022, ARCH PHARM RES, V45, P938
   Kumar S, 2021, ADV DRUG DELIVER REV, V176, DOI 10.1016/j.addr.2021.113869
   Li CX, 2019, WORLD J GASTROENTERO, V25, P5120, DOI 10.3748/wjg.v25.i34.5120
   Li DD, 2022, NUTRIENTS, V14, DOI 10.3390/nu14153247
   Li FX, 2021, DIABETES METAB J, V45, P417, DOI 10.4093/dmj.2020.0039
   Li HX, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.644129
   Li RR, 2022, J TRANSL MED, V20, DOI 10.1186/s12967-022-03540-2
   Li XY, 2020, LIVER INT, V40, P1378, DOI 10.1111/liv.14428
   Li YF, 2021, CELL METAB, V33, P2004, DOI 10.1016/j.cmet.2021.09.008
   Liu B, 2021, J CLIN INVEST, V131, DOI 10.1172/JCI144801
   Liu HY, 2018, ONCOTARGET, V9, P2887, DOI [10.18632/oncotarget.20812, 10.18632/oncotarget.23208]
   Lu QR, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.710420
   Luo G, 2022, MOLECULES, V27, DOI 10.3390/molecules27154966
   Ma ZJ, 2023, J DIABETES RES, V2023, DOI 10.1155/2023/5891532
   Marengo A, 2016, ANNU REV MED, V67, P103, DOI 10.1146/annurev-med-090514-013832
   Martínez-Chantar ML, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.640869
   Mohammed S, 2021, FREE RADICAL BIO MED, V164, P315, DOI 10.1016/j.freeradbiomed.2020.12.449
   Morishita A, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0261310
   Nasiri-Ansari N, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22020818
   Nguyen DV, 2022, ARCH PHARM RES, V45, P836, DOI 10.1007/s12272-022-01415-0
   Nguyen TL, 2021, ARCH PHARM RES, V44, P241, DOI 10.1007/s12272-020-01304-4
   Parlati L, 2021, JHEP REP, V3, DOI 10.1016/j.jhepr.2021.100346
   Pawlak M, 2015, J HEPATOL, V62, P720, DOI 10.1016/j.jhep.2014.10.039
   Pei K, 2020, BIOMED RES INT, V2020, DOI 10.1155/2020/4020249
   Peng C, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.603926
   Pennisi G, 2022, NUTR METAB CARDIOVAS, V32, P2279, DOI 10.1016/j.numecd.2022.07.001
   Polyzos SA, 2019, METABOLISM, V92, P82, DOI 10.1016/j.metabol.2018.11.014
   Prasomthong J, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-11027-9
   Puengel T, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23126696
   Puengel T, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23052668
   Qiao JT, 2018, METABOLISM, V81, P13, DOI 10.1016/j.metabol.2017.09.010
   Rubio C, 2020, MOL METAB, V35, DOI 10.1016/j.molmet.2020.01.018
   Sandoval V, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10050637
   Segal-Salto M, 2020, JHEP REP, V2, DOI 10.1016/j.jhepr.2019.100064
   Shaaban HH, 2022, LIFE SCI, V308, DOI 10.1016/j.lfs.2022.120956
   Shabalala SC, 2020, BIOMED PHARMACOTHER, V131, DOI 10.1016/j.biopha.2020.110785
   Shih PH, 2021, MAR DRUGS, V19, DOI 10.3390/md19030148
   Softic S, 2020, CRIT REV CL LAB SCI, V57, P308, DOI 10.1080/10408363.2019.1711360
   Song DF, 2020, BMC COMPLEMENT MED, V20, DOI 10.1186/s12906-019-2811-2
   Stephenson Kristen, 2018, Gene Expression-The Journal of Liver Research, V18, P5, DOI 10.3727/105221617X15093707969658
   Tacke F, 2023, J Hepatol
   Tanase DM, 2020, J DIABETES RES, V2020, DOI 10.1155/2020/3920196
   ter Horst KW, 2017, NUTRIENTS, V9, DOI 10.3390/nu9090981
   Todoric J, 2020, NAT METAB, V2, P1034, DOI 10.1038/s42255-020-0261-2
   Torres LF, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/4168380
   Tsuchida T, 2018, J HEPATOL, V69, P988, DOI 10.1016/j.jhep.2018.07.010
   Tsuchida T, 2018, J HEPATOL, V69, P385, DOI 10.1016/j.jhep.2018.03.011
   Ul Hasan A, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20020387
   Valenzuela-Vallejo L, 2022, METABOLISM, V136, DOI 10.1016/j.metabol.2022.155248
   Márquez-Quiroga LV, 2022, BIOCHEM PHARMACOL, V195, DOI 10.1016/j.bcp.2021.114845
   Vasques-Monteiro IML, 2021, NUTR RES, V91, P26, DOI 10.1016/j.nutres.2021.04.008
   Veskovic M, 2019, EUR J PHARMACOL, V848, P39, DOI 10.1016/j.ejphar.2019.01.043
   Wang S, 2022, NUTRIENTS, V14, DOI 10.3390/nu14153050
   Wu LW, 2021, BIOMED PHARMACOTHER, V136, DOI 10.1016/j.biopha.2021.111255
   Xiao Q, 2019, INT J ENDOCRINOL, V2019, DOI 10.1155/2019/7514802
   Xu B, 2018, J HEPATOL, V68, P773, DOI 10.1016/j.jhep.2017.11.040
   Xu HX, 2021, HEPATOLOGY, V73, P1327, DOI 10.1002/hep.31428
   Yan TT, 2018, DRUG METAB DISPOS, V46, P1310, DOI 10.1124/dmd.118.082008
   Yang HL, 2022, BIOMED RES INT, V2022, DOI 10.1155/2022/4801695
   Yoshimine Y, 2015, ONCOL REP, V33, P1657, DOI 10.3892/or.2015.3745
   Zhang Q, 2021, LIFE SCI, V270, DOI 10.1016/j.lfs.2021.119071
   Zhang X, 2021, GUT, V70, P761, DOI 10.1136/gutjnl-2019-319664
   Zhang ZX, 2023, NUTR RES REV, V36, P120, DOI 10.1017/S095442242100038X
   Zhao JX, 2022, KOREAN J PHYSIOL PHA, V26, P541, DOI 10.4196/kjpp.2022.26.6.541
   Zhao P, 2020, SCIENCE, V367, P652, DOI 10.1126/science.aay0542
   Zhao WC, 2022, KOREAN J PHYSIOL PHA, V26, P427, DOI 10.4196/kjpp.2022.26.6.427
   Zheng T, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/8597897
   Zhu W, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10123306
NR 104
TC 5
Z9 5
U1 5
U2 14
PU KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
PI SEOUL
PA C/O EDITORIAL OFFICE, 448-13 SEOKYO-DONG, SEOUL, SOUTH KOREA
SN 1226-4512
EI 2093-3827
J9 KOREAN J PHYSIOL PHA
JI KOREAN J. PHYSIOL. PHARMACOL.
PD JUL
PY 2023
VL 27
IS 4
BP 299
EP 310
DI 10.4196/kjpp.2023.27.4.299
PG 12
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA L8OL7
UT WOS:001025801700002
PM 37386828
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU LaChance, L
   Aucoin, M
   Cooley, K
AF LaChance, Laura
   Aucoin, Monique
   Cooley, Kieran
TI Design and pilot evaluation of an evidence-based worksheet and clinician
   guide to facilitate nutrition counselling for patients with severe
   mental illness
SO BMC PSYCHIATRY
LA English
DT Article
DE Diet; Nutrition; Worksheet; Psychosis; Schizophrenia; Counseling;
   Lifestyle; Knowledge translation; Clinical tool; Patient education
ID SCHIZOPHRENIA SPECTRUM DISORDERS; CARDIOMETABOLIC RISK; CARE;
   INDIVIDUALS; INFORMATION; PSYCHOSIS; PEOPLE
AB Background Schizophrenia spectrum disorders (SSD) are severe, persistent mental illnesses resulting in considerable disability and premature mortality. Emerging evidence suggests that diet may be a modifiable risk factor in mental illness; however, use of nutritional counselling as a component of psychiatric clinical practice is limited. The objective of this project is the design and evaluate a worksheet and clinician guide for use in facilitating nutritional counseling in the context of existing mental health care. Methods The worksheet and clinician guide were developed based on the results of a recent scoping review on the relationship between diet and mental health symptoms among individuals with SSD. A feedback process involved a focus group with psychiatrists and interviews with individuals with lived experience with psychosis. Participants were asked a series of structured and open-ended questions. Interviews were transcribed and data units were allocated to categories from an existing framework. The comments were used to guide modifications to the worksheet and clinician guide. A brief interview with all participants was completed to gather feedback on the final version. Results Five psychiatrist participants and six participants with lived experience completed interviews. Participants provided positive comments related to the worksheet design, complexity and inclusion of interactive components. A novel theme emerged relating to the lack of nutritional counselling in psychiatric training and clinical practice. Many constructive comments were provided which resulted in meaningful revisions and improvements to the worksheet and clinician guide design and content. All participants were satisfied with the final versions. Conclusions A worksheet and clinician guide designed to facilitate nutritional counselling with individuals with SSD was found to be acceptable to all participants following a process of feedback and revision. Further research and dissemination efforts aimed at increasing the use of nutritional counselling in psychiatric practice are warranted.
C1 [LaChance, Laura] McGill Univ, Dept Psychiat, Ludmer Res & Training Bldg,1033 Pine Ave West, Montreal, PQ H3A 1A1, Canada.
   [LaChance, Laura] St Marys Hosp, 3830 Lacombe Ave, Montreal, PQ H3T 1M5, Canada.
   [Aucoin, Monique; Cooley, Kieran] Canadian Coll Naturopath Med, 1255 Sheppard Ave E, N York, ON M2K 1E2, Canada.
   [Cooley, Kieran] Univ Technol Sydney, Ultimo, Australia.
   [Cooley, Kieran] Pacific Coll Hlth Sci, San Diego, CA USA.
   [Cooley, Kieran] Southern Cross Univ, Natl Ctr Naturopath Med, Lismore, NSW, Australia.
C3 McGill University; University of Technology Sydney; Southern Cross
   University
RP LaChance, L (corresponding author), McGill Univ, Dept Psychiat, Ludmer Res & Training Bldg,1033 Pine Ave West, Montreal, PQ H3A 1A1, Canada.; LaChance, L (corresponding author), St Marys Hosp, 3830 Lacombe Ave, Montreal, PQ H3T 1M5, Canada.
EM laura.lachance@mail.mcgill.ca
RI Cooley, Kieran/L-3080-2019; Aucoin, Monique/KHX-8889-2024
FU Canadian CAM Research Fund
FX This project was funded by the Canadian CAM Research Fund. The funders
   did not play a role in the study design, conduct, data analysis,
   interpretation, or manuscript preparation.
CR Agarwal SM, 2020, NEUROPHARMACOLOGY, V163, DOI 10.1016/j.neuropharm.2019.05.010
   Arnett DK, 2019, J AM COLL CARDIOL, V74, pE177, DOI 10.1016/j.jacc.2019.03.010
   Aucoin M, 2020, NEUROPSYCHOBIOLOGY, V79, P20, DOI 10.1159/000493399
   Baute Vanessa, 2018, Glob Adv Health Med, V7, p2164956118795995, DOI 10.1177/2164956118795995
   Bonfioli E, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-78
   Chiu M, 2018, CAN J PSYCHIAT, V63, P481, DOI 10.1177/0706743717741061
   Correll CU, 2014, JAMA PSYCHIAT, V71, P1350, DOI 10.1001/jamapsychiatry.2014.1314
   Hert M, 2012, NAT REV ENDOCRINOL, V8, P114, DOI 10.1038/nrendo.2011.156
   Devries S, 2017, CURR CARDIOL REP, V19, DOI 10.1007/s11886-017-0890-6
   Dipasquale S, 2013, J PSYCHIATR RES, V47, P197, DOI 10.1016/j.jpsychires.2012.10.005
   Eaton CB, 2002, AM J PREV MED, V23, P174, DOI 10.1016/S0749-3797(02)00494-4
   El-Mallakh P, 2007, ARCH PSYCHIAT NURS, V21, P49, DOI 10.1016/j.apnu.2006.10.004
   Fiore MC, 2000, JAMA-J AM MED ASSOC, V283, P3244
   Fishbein M, 2003, COMMUN THEOR, V13, P164, DOI 10.1111/j.1468-2885.2003.tb00287.x
   Flodgren G, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD000125.pub5
   Forsetlund L, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003030.pub2
   Galderisi S, 2021, EUR PSYCHIAT, V64, DOI 10.1192/j.eurpsy.2020.115
   Gatov E, 2017, CAN MED ASSOC J, V189, pE1177, DOI 10.1503/cmaj.161351
   Giguere Anik, 2020, Cochrane Database Syst Rev, V8, pCD004398, DOI 10.1002/14651858.CD004398.pub4
   Government of Canada, EAT WELL CAN FOOD GU
   Hand RK, 2015, J ACAD NUTR DIET, V115, P816, DOI 10.1016/j.jand.2015.01.010
   Harvey JAH, 2010, FRONTLINE GASTROENTE, V1, P19, DOI 10.1136/fg.2009.000232
   Jacka FN, 2017, BMC MED, V15, DOI 10.1186/s12916-017-0791-y
   Lenz Matthias, 2009, Psychosoc Med, V6, pDoc05, DOI 10.3205/psm000061
   Malterud K, 2016, QUAL HEALTH RES, V26, P1753, DOI 10.1177/1049732315617444
   Marriott S, 2000, QUAL HEALTH CARE, V9, P58, DOI 10.1136/qhc.9.1.58
   McMorris Tressa, 2016, Ment Health Clin, V6, P101, DOI 10.9740/mhc.2016.03.101
   Mörkl S, 2021, NUTRIENTS, V13, DOI 10.3390/nu13030822
   Molendijk M, 2018, J AFFECT DISORDERS, V226, P346, DOI 10.1016/j.jad.2017.09.022
   Myles N, 2012, J CLIN PSYCHIAT, V73, P468, DOI 10.4088/JCP.11r07222
   Papadaki A, 2006, HEALTH EDUC RES, V21, P206, DOI 10.1093/her/cyh057
   Pillinger T, 2020, LANCET PSYCHIAT, V7, P64, DOI 10.1016/S2215-0366(19)30416-X
   Rolls K, 2016, J MED INTERNET RES, V18, DOI 10.2196/jmir.5312
   Sarris J, 2019, DRUGS, V79, P929, DOI 10.1007/s40265-019-01134-9
   Sarris J, 2015, LANCET PSYCHIAT, V2, P271, DOI 10.1016/S2215-0366(14)00051-0
   Stubbs B, 2016, SCHIZOPHR RES, V171, P103, DOI 10.1016/j.schres.2016.01.034
   Teasdale SB, 2017, J HUM NUTR DIET, V30, P545, DOI 10.1111/jhn.12473
   Teasdale S, 2020, BRAIN BEHAV IMMUN-HL, V5, DOI 10.1016/j.bbih.2020.100070
   Teasdale SB, 2019, BRIT J PSYCHIAT, V214, P251, DOI 10.1192/bjp.2019.20
   Teasdale SB, 2016, BRIT J NUTR, V115, P1987, DOI 10.1017/S0007114516001033
   TOWNSEND J, 1994, BMJ-BRIT MED J, V309, P923, DOI 10.1136/bmj.309.6959.923
   Weiss BD, 2005, ANN FAM MED, V3, P514, DOI 10.1370/afm.405
   Wenger E., 2002, Cultivating communities of practice: A guide to managing knowledge
NR 43
TC 0
Z9 0
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD NOV 10
PY 2021
VL 21
IS 1
AR 556
DI 10.1186/s12888-021-03575-7
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA WV0NN
UT WOS:000716933500005
PM 34758760
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Vinberg, M
   Mcintyre, RS
   Giraldi, A
   Coello, K
AF Vinberg, Maj
   Mcintyre, Roger S.
   Giraldi, Annamaria
   Coello, Klara
TI Struggling Can Also Show on the Inside: Current Knowledge of the Impact
   of Childhood Maltreatment on Biomarkers in Mood Disorderss
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Review
DE biomarkers; childhood maltreatment; mood disorders; biosignatures;
   biotype
ID PITUITARY-ADRENAL AXIS; BIPOLAR DISORDER; SALIVARY CORTISOL;
   NEUROTROPHIC FACTOR; METABOLIC SYNDROME; HEALTHY TWINS; LOW-RISK;
   EXPERIENCES; DEPRESSION; STRESS
AB The link between childhood maltreatment and mood disorders is complex and involves multiple bio-psycho-social factors that affect multiple molecular pathways. The present narrative review aims to clarify the current understanding of the impact of childhood maltreatment on biomarkers in patients with mood disorders and their first-degree relatives. Neurotransmitters, such as serotonin, dopamine, norepinephrine, and hormones (eg the stress hormone cortisol), play a crucial role in regulating mood and emotion. Childhood maltreatment can alter and affect the levels and functioning of these neurotransmitters in the brain; further, childhood maltreatment can lead to structural and connectivity changes in the brain, hence contributing to the development of mood disorders and moderating illness presentation and modifying response to treatments. Childhood maltreatment information, therefore, appears mandatory in treatment planning and is a critical factor in therapeutic algorithms. Further research is needed to fully understand these pathways and develop new treatment modalities for individuals with mood disorders who have experienced childhood maltreatment and effective preventive interventions for individuals at risk of developing mood disorders.
C1 [Vinberg, Maj] Mental Hlth Ctr Northern Zealand, Early Multimodular Prevent & Intervent Res Inst EM, Mental Hlth Serv CPH, Copenhagen, Denmark.
   [Vinberg, Maj; Giraldi, Annamaria] Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark.
   [Mcintyre, Roger S.] Univ Hlth Network, Toronto Western Hosp, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.
   [Mcintyre, Roger S.] Univ Toronto, Inst Med Sci, Toronto, ON, Canada.
   [Giraldi, Annamaria] Copenhagen Univ Hosp, Mental Hlth Ctr Copenhagen, Sexol Clin, Copenhagen, Denmark.
   [Coello, Klara] Copenhagen Affect Disorder Res Ctr CAD, Psychiat Ctr Copenhagen, Frederiksberg, Denmark.
   [Vinberg, Maj] Dyrehavevej 48, DK-3400 Hillerod, Denmark.
C3 University of Copenhagen; University of Toronto; University Health
   Network Toronto; University of Toronto; University of Copenhagen;
   Copenhagen University Hospital
RP Vinberg, M (corresponding author), Dyrehavevej 48, DK-3400 Hillerod, Denmark.
EM maj.vinberg@regionh.dk
RI Coello, Klara/AAZ-6545-2020; Vinberg/ABC-7493-2021; Giraldi,
   Annamaria/AAW-6292-2020; McIntyre, Roger/C-9998-2019
OI Vinberg, Maj/0000-0002-5982-1335
CR Aas M, 2023, PSYCHIAT RES, V320, DOI 10.1016/j.psychres.2022.115045
   Aas M, 2019, SCHIZOPHR RES, V213, P65, DOI 10.1016/j.schres.2019.01.011
   Aas M, 2019, SCHIZOPHR RES, V205, P45, DOI 10.1016/j.schres.2018.08.007
   Aas M, 2016, INT J BIPOLAR DISORD, V4, DOI 10.1186/s40345-015-0042-0
   Alameda L, 2023, MOL PSYCHIATR, V28, P2095, DOI 10.1038/s41380-023-02044-9
   Andresen JB, 2022, WORLD PSYCHIATRY, V21, P427, DOI 10.1002/wps.21008
   Baldwin JR, 2019, JAMA PSYCHIAT, V76, P584, DOI 10.1001/jamapsychiatry.2019.0097
   Barczyk ZA, 2023, BIPOLAR DISORD, V25, P263, DOI 10.1111/bdi.13321
   Baumeister D, 2016, MOL PSYCHIATR, V21, P642, DOI 10.1038/mp.2015.67
   Bellis MA, 2014, B WORLD HEALTH ORGAN, V92, P641, DOI 10.2471/BLT.13.129247
   Benjet C, 2010, J PSYCHIATR RES, V44, P732, DOI 10.1016/j.jpsychires.2010.01.004
   Bernard C., 1878, Lecons sur les phenomenes de la vie communs aux animaux et aux vegetaux
   Bernard K, 2017, PSYCHONEUROENDOCRINO, V78, P57, DOI 10.1016/j.psyneuen.2017.01.005
   Bernstein DP, 2003, CHILD ABUSE NEGLECT, V27, P169, DOI 10.1016/S0145-2134(02)00541-0
   Black CN, 2017, PSYCHONEUROENDOCRINO, V80, P56, DOI 10.1016/j.psyneuen.2017.03.003
   Bourassa KJ, 2023, PREV SCI, V24, DOI 10.1007/s11121-022-01431-y
   Brandt JM, 2023, PSYCHOL MED, V53, P6635, DOI 10.1017/S0033291722004020
   Broeks CW, 2023, COMPR PSYCHONEUROEND, V14, DOI 10.1016/j.cpnec.2023.100167
   Brown M, 2021, PHARMACOL BIOCHEM BE, V211, DOI 10.1016/j.pbb.2021.173291
   Bücker J, 2015, ACTA PSYCHIAT SCAND, V131, P360, DOI 10.1111/acps.12358
   Campbell JA, 2016, AM J PREV MED, V50, P344, DOI 10.1016/j.amepre.2015.07.022
   Cannon WB, 1929, PHYSIOL REV, V9, P399, DOI 10.1152/physrev.1929.9.3.399
   Caspi A, 2003, SCHIZOPHR RES, V65, P87, DOI 10.1016/S0920-9964(03)00056-2
   Caspi A, 2003, SCIENCE, V301, P386, DOI 10.1126/science.1083968
   Caspi A, 2002, SCIENCE, V297, P851, DOI 10.1126/science.1072290
   Caspi A, 2006, NAT REV NEUROSCI, V7, P583, DOI 10.1038/nrn1925
   Cattane N, 2022, EUR NEUROPSYCHOPHARM, V58, P55, DOI 10.1016/j.euroneuro.2022.02.002
   Chahal R, 2022, DEV PSYCHOPATHOL, V34, P557, DOI 10.1017/S0954579421001814
   Coello K, 2019, PSYCHONEUROENDOCRINO, V99, P183, DOI 10.1016/j.psyneuen.2018.09.020
   Copeland WE, 2022, J CHILD PSYCHOL PSYC, V63, P1308, DOI 10.1111/jcpp.13575
   Daniels TE, 2023, PSYCHONEUROENDOCRINO, V149, DOI 10.1016/j.psyneuen.2022.106007
   Deighton S, 2018, PSYCHIAT RES, V269, P719, DOI 10.1016/j.psychres.2018.08.097
   Derome M, 2023, EUR ARCH PSY CLIN N, V273, P1061, DOI 10.1007/s00406-023-01564-3
   Dualibe AL, 2017, HARVARD REV PSYCHIAT, V25, P198, DOI 10.1097/HRP.0000000000000154
   Duffy A, 2011, EARLY INTERV PSYCHIA, V5, P181, DOI 10.1111/j.1751-7893.2011.00276.x
   Duffy KA, 2018, ANN NY ACAD SCI, V1428, P151, DOI 10.1111/nyas.13928
   Ehrlich KB, 2021, DEV PSYCHOBIOL, V63, P529, DOI 10.1002/dev.22031
   Eriksen JKD, 2022, EUR PSYCHIAT, V65, DOI 10.1192/j.eurpsy.2022.2300
   Falcone T, 2015, J PSYCHIATR RES, V62, P14, DOI 10.1016/j.jpsychires.2014.12.002
   Fares-Otero NE, 2023, ACTA PSYCHIAT SCAND, V148, P142, DOI 10.1111/acps.13557
   Farrell C, 2018, PSYCHIAT RES, V265, P341, DOI 10.1016/j.psychres.2018.04.064
   Gilbert R, 2009, LANCET, V373, P68, DOI 10.1016/S0140-6736(08)61706-7
   Gill H, 2020, J AFFECT DISORDERS, V272, P1, DOI 10.1016/j.jad.2020.03.145
   Holz NE, 2023, BIOL PSYCHIAT, V93, P430, DOI 10.1016/j.biopsych.2022.10.019
   Hughes K, 2017, LANCET PUBLIC HEALTH, V2, pE356, DOI 10.1016/S2468-2667(17)30118-4
   Infurna MR, 2016, J AFFECT DISORDERS, V190, P47, DOI 10.1016/j.jad.2015.09.006
   Jauhar S, 2023, J PSYCHOPHARMACOL, V37, P237, DOI 10.1177/02698811231161813
   Jiang S, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00808
   Jorgensen A, 2023, AGING CELL, V22, DOI 10.1111/acel.13839
   Jorgensen A, 2022, JAMA PSYCHIAT, V79, P920, DOI 10.1001/jamapsychiatry.2022.2066
   Karottki NFL, 2020, INT J BIPOLAR DISORD, V8, DOI 10.1186/s40345-020-00181-6
   Kerr DM, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0243685
   Knorr U, 2010, PSYCHONEUROENDOCRINO, V35, P1275, DOI 10.1016/j.psyneuen.2010.04.001
   Kroksmark H, 2018, NORD J PSYCHIAT, V72, P462, DOI 10.1080/08039488.2018.1472295
   Krug EG, 2002, LANCET, V360, P1083, DOI 10.1016/S0140-6736(02)11133-0
   Kuzminskaite E, 2022, LANCET PSYCHIAT, V9, P860, DOI 10.1016/S2215-0366(22)00227-9
   Lang JS, 2020, EUR CHILD ADOLES PSY, V29, P1329, DOI 10.1007/s00787-019-01329-1
   LeMoult J, 2020, J AM ACAD CHILD PSY, V59, P842, DOI 10.1016/j.jaac.2019.10.011
   Li MZ, 2023, TRAUMA VIOLENCE ABUS, V24, P2560, DOI 10.1177/15248380221102558
   Li ZA, 2023, JAMA NETW OPEN, V6, DOI 10.1001/jamanetworkopen.2023.20276
   Lippard ETC, 2022, PHARMACOL BIOCHEM BE, V215, DOI 10.1016/j.pbb.2022.173361
   Lippard ETC, 2020, AM J PSYCHIAT, V177, P20, DOI 10.1176/appi.ajp.2019.19010020
   Liu JL, 2023, JCPP ADV, V3, DOI 10.1002/jcv2.12156
   Lucido MJ, 2021, PHARMACOL REV, V73, P1084, DOI 10.1124/pharmrev.120.000043
   McEwen BS, 2010, ANN NY ACAD SCI, V1186, P190, DOI 10.1111/j.1749-6632.2009.05331.x
   Mcintyre RS, 2023, WORLD PSYCHIATRY, V22, P394, DOI 10.1002/wps.21120
   McIntyre RS, 2020, LANCET, V396, P1841, DOI 10.1016/S0140-6736(20)31544-0
   McIntyre RS, 2012, INT J PSYCHIAT MED, V43, P165, DOI 10.2190/PM.43.2.e
   McKay MT, 2021, ACTA PSYCHIAT SCAND, V143, P189, DOI 10.1111/acps.13268
   Melo MCA, 2016, J PSYCHIATR RES, V83, P211, DOI 10.1016/j.jpsychires.2016.09.005
   Miller GE, 2021, AM J PSYCHIAT, V178, P313, DOI 10.1176/appi.ajp.2020.20050635
   Mitroshina EV, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms242216416
   Moody G, 2018, BMC PUBLIC HEALTH, V18, DOI 10.1186/s12889-018-6044-y
   Moraes JB, 2018, METAB BRAIN DIS, V33, P1081, DOI 10.1007/s11011-018-0209-3
   Munkholm K, 2016, MOL PSYCHIATR, V21, P216, DOI 10.1038/mp.2015.54
   Munkholm K, 2012, BIPOLAR DISORD, V14, P684, DOI 10.1111/bdi.12005
   Murri MB, 2012, PSYCHONEUROENDOCRINO, V37, P629, DOI 10.1016/j.psyneuen.2011.08.013
   Nanni V, 2012, AM J PSYCHIAT, V169, P141, DOI 10.1176/appi.ajp.2011.11020335
   Nelson CA, 2020, BMJ-BRIT MED J, V371, DOI 10.1136/bmj.m3048
   Norman RE, 2012, PLOS MED, V9, DOI 10.1371/journal.pmed.1001349
   Nothling J, 2020, WORLD J BIOL PSYCHIA, V21, P493, DOI 10.1080/15622975.2019.1583369
   O'Dea GA, 2023, ARCH WOMEN MENT HLTH, V26, P441, DOI 10.1007/s00737-023-01332-1
   O'Shields J, 2022, J AFFECT DISORDERS, V311, P173, DOI 10.1016/j.jad.2022.05.077
   Ottesen NM, 2020, PSYCHOL MED, V50, P1736, DOI 10.1017/S003329171900182X
   Palmos AB, 2019, BJPSYCH OPEN, V5, DOI 10.1192/bjo.2018.80
   Parade SH, 2021, TRANSL PSYCHIAT, V11, DOI 10.1038/s41398-021-01207-y
   Park C, 2019, NEUROSCI BIOBEHAV R, V102, P139, DOI 10.1016/j.neubiorev.2019.04.010
   Péterfalvi A, 2019, FRONT PSYCHOL, V10, DOI 10.3389/fpsyg.2019.01798
   Reese EM, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19105944
   Ryu S, 2023, J CLIN MED, V12, DOI 10.3390/jcm12144574
   Saadedine M, 2023, J SEX MED, V20, P792, DOI 10.1093/jsxmed/qdad053
   Saba SK, 2023, CHILD ABUSE NEGLECT, V144, DOI 10.1016/j.chiabu.2023.106369
   Salmon S, 2022, BMC PUBLIC HEALTH, V22, DOI [10.1186/s12889-022-13310-w, 10.1186/s12889-022-12926-2]
   Schalinski I, 2019, PSYCHONEUROENDOCRINO, V108, P35, DOI 10.1016/j.psyneuen.2019.06.007
   Schuch FB, 2019, DEPRESS ANXIETY, V36, P846, DOI 10.1002/da.22915
   Sideli L, 2023, SOC PSYCH PSYCH EPID, V58, P1573, DOI 10.1007/s00127-023-02513-0
   Souama C, 2024, PSYCHOL MED, V54, P1373, DOI 10.1017/S0033291723003264
   Steven S, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/7092151
   Teicher MH, 2022, MOL PSYCHIATR, V27, P1331, DOI 10.1038/s41380-021-01367-9
   Tickell AM, 2022, EARLY INTERV PSYCHIA, V16, P1121, DOI 10.1111/eip.13260
   Tiwari A, 2018, CLIN PSYCHOL REV, V66, P69, DOI 10.1016/j.cpr.2018.01.006
   Tundo A, 2023, LIFE-BASEL, V13, DOI 10.3390/life13041043
   Tural U, 2022, WORLD J BIOL PSYCHIA, V23, P456, DOI 10.1080/15622975.2021.2013042
   Uher R, 2014, FRONT PSYCHIATRY, V5, DOI 10.3389/fpsyt.2014.00048
   Vadukapuram R, 2022, J NERV MENT DIS, V210, P397, DOI 10.1097/NMD.0000000000001480
   Vibhakar V, 2019, J AFFECT DISORDERS, V255, P77, DOI 10.1016/j.jad.2019.05.005
   Vinberg M, 2020, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.00689
   Vinberg M, 2014, PROG NEURO-PSYCHOPH, V48, P193, DOI 10.1016/j.pnpbp.2013.10.007
   Vinberg M, 2014, PSYCHONEUROENDOCRINO, V39, P179, DOI 10.1016/j.psyneuen.2013.09.007
   Vinberg M, 2008, PSYCHIAT RES, V161, P292, DOI 10.1016/j.psychres.2007.08.001
   Vinberg MR, 2016, Dan Med J, V63, P1
   Vyas CM, 2023, J PSYCHIATR RES, V163, P357, DOI 10.1016/j.jpsychires.2023.05.069
   Warhaftig G, 2023, NEUROSCI BIOBEHAV R, V148, DOI 10.1016/j.neubiorev.2023.105113
   Wegman HL, 2009, PSYCHOSOM MED, V71, P805, DOI 10.1097/PSY.0b013e3181bb2b46
   Wolke D, 2015, ARCH DIS CHILD, V100, P879, DOI 10.1136/archdischild-2014-306667
NR 115
TC 1
Z9 1
U1 1
U2 3
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2024
VL 20
BP 583
EP 595
DI 10.2147/NDT.S383322
PG 13
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA LD4U3
UT WOS:001184836400001
PM 38496323
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jee, SH
   Kim, HJ
   Lee, J
AF Jee, SH
   Kim, HJ
   Lee, J
TI Obesity, insulin resistance and cancer risk
SO YONSEI MEDICAL JOURNAL
LA English
DT Review
DE obesity; insulin resistance; cancer; mechanism
ID DIABETES-MELLITUS; BREAST-CANCER; COLORECTAL-CANCER; METABOLIC SYNDROME;
   OXIDATIVE STRESS; KOREAN MEN; CARDIOVASCULAR-DISEASE; GLUCOSE;
   HYPERTENSION; COLON
AB Obesity is a known cause of metabolic syndrome which includes Type 11 diabetes, hypertension, and dyslipidemia. it is well documented that insulin resistance contributes to the mortality and the incidence of metabolic syndromes including central obesity, dyslipidemia, hyperglycemia and hypertension. Both obesity and diabetes are emerging topics for researchers to consider as having a possible causal association with cancer since the two factors have been viewed as risk factors for cancer. The present paper introduced the hypothesis of a possible causal relationship between obesity, insulin resistance and cancer and reviews relevant existing studies in this area. More efforts and studies are needed to clarify the mechanisms and the common risk factors which might be incorporated into interventions to prevent cancer and cardiovascular diseases as top causes of death.
C1 Yonsei Univ, Grad Sch Publ Hlth, Dept Epidemiol & Hlth Promot, Seoul 120752, South Korea.
   Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
   Eulji Univ, Sch Med, Dept Family Med, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System; Johns Hopkins
   University; Johns Hopkins Bloomberg School of Public Health; Eulji
   University
RP Yonsei Univ, Grad Sch Publ Hlth, Dept Epidemiol & Hlth Promot, 134 Shinchon Dong, Seoul 120752, South Korea.
EM jsunha@yumc.yonsei.ac.kr
RI Jiang, Shu-Heng/M-6584-2019
CR Calle EE, 2004, NAT REV CANCER, V4, P579, DOI 10.1038/nrc1408
   Chapman IM, 1998, J CLIN ENDOCR METAB, V83, P2836, DOI 10.1210/jc.83.8.2836
   Choi MY, 2005, KIDNEY INT, V67, P647, DOI 10.1111/j.1523-1755.2005.67137.x
   Cooney KA, 2005, JAMA-J AM MED ASSOC, V293, P235, DOI 10.1001/jama.293.2.235
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   Dandona P, 2002, DIABETOLOGIA, V45, P924, DOI 10.1007/s00125-001-0766-5
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Garrison RJ, 1996, CURR OPIN LIPIDOL, V7, P199, DOI 10.1097/00041433-199608000-00005
   GIOVANNUCCI E, 1995, CANCER CAUSE CONTROL, V6, P164, DOI 10.1007/BF00052777
   Han CZ, 2005, ENDOCRINE, V26, P19, DOI 10.1385/ENDO:26:1:019
   Hjalgrim H, 1997, J INTERN MED, V241, P471
   Hu FB, 1999, JNCI-J NATL CANCER I, V91, P542, DOI 10.1093/jnci/91.6.542
   Jee SH, 2005, JAMA-J AM MED ASSOC, V293, P194, DOI 10.1001/jama.293.2.194
   Kaaks R, 2002, CANCER EPIDEM BIOMAR, V11, P1531
   Kaaks R, 1996, CANCER CAUSE CONTROL, V7, P605, DOI 10.1007/BF00051703
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Key TJ, 2001, LANCET ONCOL, V2, P133, DOI 10.1016/S1470-2045(00)00254-0
   Khandwala HM, 2000, ENDOCR REV, V21, P215, DOI 10.1210/er.21.3.215
   Komninou D, 2003, EXP BIOL MED, V228, P396, DOI 10.1177/153537020322800410
   Kono S, 1998, CANCER CAUSE CONTROL, V9, P441, DOI 10.1023/A:1008879920140
   La Vecchia C, 1997, CANCER EPIDEM BIOMAR, V6, P1007
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lee SY, 2002, J HYPERTENS, V20, P617, DOI 10.1097/00004872-200204000-00017
   Maddux BA, 2001, DIABETES, V50, P404, DOI 10.2337/diabetes.50.2.404
   Matsuoka T, 1997, J CLIN INVEST, V99, P144, DOI 10.1172/JCI119126
   NAKAZONO K, 1991, P NATL ACAD SCI USA, V88, P10045, DOI 10.1073/pnas.88.22.10045
   Nilsen TI, 2001, BRIT J CANCER, P417
   OHARA Y, 1993, J CLIN INVEST, V91, P2546, DOI 10.1172/JCI116491
   Renehan AG, 2005, LANCET, V365, P1449, DOI 10.1016/S0140-6736(05)66399-4
   Tsushima M, 2005, DIGEST DIS SCI, V50, P499, DOI 10.1007/s10620-005-2464-5
   Tuomilehto J, 2003, DIABETES CARE, V26, P61
   Weiderpass E, 1997, INT J CANCER, V71, P360, DOI 10.1002/(SICI)1097-0215(19970502)71:3<360::AID-IJC9>3.0.CO;2-W
   Weiderpass E, 1998, SCAND J WORK ENV HEA, V24, P165, DOI 10.5271/sjweh.295
   Will JC, 1998, AM J EPIDEMIOL, V147, P816, DOI 10.1093/oxfordjournals.aje.a009534
   Wolf I, 2005, LANCET ONCOL, V6, P103, DOI 10.1016/S1470-2045(05)01736-5
   Yancik R, 2001, JAMA-J AM MED ASSOC, V285, P885, DOI 10.1001/jama.285.7.885
NR 36
TC 69
Z9 78
U1 0
U2 6
PU YONSEI UNIV COLL MEDICINE
PI SEOUL
PA 50-1 YONSEI-RO, SEODAEMUN-GU, SEOUL 120-752, SOUTH KOREA
SN 0513-5796
EI 1976-2437
J9 YONSEI MED J
JI Yonsei Med. J.
PD AUG 31
PY 2005
VL 46
IS 4
BP 449
EP 455
DI 10.3349/ymj.2005.46.4.449
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 961CR
UT WOS:000231640000001
PM 16127767
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Bhutia, RD
   Khandelwal, B
   Sherpa, ML
   Singh, TA
AF Bhutia, Rinchen D.
   Khandelwal, Bidita
   Sherpa, Mingma L.
   Singh, T. A.
TI Oxidation products of DNA, lipid and protein among the individuals
   progressing towards metabolic syndrome
SO INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS
LA English
DT Article
DE DNA damage; Lipid peroxidation; Metabolic syndrome; Oxidative stress;
   Protein carbonyl
ID INHIBITOR KAPPA-B; MONONUCLEAR-CELLS; URINARY
   8-HYDROXY-2'-DEOXYGUANOSINE; INCREASE; STRESS; DECREASE; OXYGEN;
   DISEASE; MARKERS; DAMAGE
AB Oxidative stress (OS) is an early event and at the same time also a consequence in the pathology of MetS. We investigated if oxidation markers of DNA, lipid and protein increased with an increase in the risk parameters of MetS. Participants (male:70, female:90 >= 20 yrs) were categorized based on the number of risk factors they had as 3 Risk, 2 Risk, 1 Risk and 0 Risk for MetS and were evaluated for various oxidation markers. Protein carbonyl and advanced oxidation protein product (protein oxidation marker) differed significantly between the four study group while malondialdehyde and hydroxynonenal (lipid peroxidation marker) did not. "8-OH dG" (DNA oxidation marker) differed significantly (P< 0.05) while total antioxidant capacity did not demonstrate significant difference in its values across the group (P> 0.05). Pairwise comparison for statistically significant markers(Protein oxidation markers and 8-OH dG), demonstrated that only 8-OH dG differed significantly between 0 Risk-3 Risk (P< 0.012) but not between 0 Risk-2 Risk and 0 Risk-1 Risk. Oxidative stress markers of DNA, lipid and protein do not increase with an increase in the risk parameters of MetS. However, it is indeed high in MetS with 3 and more risk parameters. Presence of 2 or 1 Risk also increases OS compared to 0 Risk. There is oxidative stress damage in MetS to lipid and protein but DNA damage was of significant consequence.
C1 [Bhutia, Rinchen D.; Khandelwal, Bidita; Sherpa, Mingma L.; Singh, T. A.] Sikkim Manipal Univ, Med Sikkim Manipal Inst Med Sci, Dept Biochem, Gangtok 737102, East Sikkim, India.
C3 Sikkim Manipal University
RP Bhutia, RD (corresponding author), Sikkim Manipal Univ, Med Sikkim Manipal Inst Med Sci, Dept Biochem, Gangtok 737102, East Sikkim, India.
EM nehcnir@yahoo.co.in
RI Sherpa, Mingma/ABB-7061-2021; Bhutia, Rinchen/AAE-6172-2021; khandelwal,
   bidita/K-4935-2012
OI Bhutia, Rinchen Doma/0000-0001-8463-2854; Sherpa, Mingma
   L/0000-0002-5905-6127
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Aljada A, 2004, AM J CLIN NUTR, V80, P51
   Aljada A, 2004, AM J CLIN NUTR, V79, P682
   Aljada A, 2006, METABOLISM, V55, P1177, DOI 10.1016/j.metabol.2006.04.016
   [Anonymous], 2007, WILEY ENCY CLIN TRIA
   Aouacheri O, 2015, CAN J DIABETES, V39, P44, DOI 10.1016/j.jcjd.2014.03.002
   Berlett BS, 1997, J BIOL CHEM, V272, P20313, DOI 10.1074/jbc.272.33.20313
   Buss IH, 1996, OXIDATIVE STRESS BIO, V23, P361
   Butkowski EG, 2017, REDOX REP, V22, P257, DOI 10.1080/13510002.2016.1215643
   CARNEY JM, 1991, P NATL ACAD SCI USA, V88, P3633, DOI 10.1073/pnas.88.9.3633
   Chen SS, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0050456, 10.1371/journal.pone.0049275, 10.1371/journal.pone.0045763, 10.1371/journal.pone.0036784]
   Dalle-Donne I, 2005, MASS SPECTROM REV, V24, P55, DOI 10.1002/mas.20006
   Davies MJ, 1999, FREE RADICAL BIO MED, V27, P1151, DOI 10.1016/S0891-5849(99)00206-3
   Dean RT, 1997, BIOCHEM J, V324, P1
   Di Minno A, 2016, ANTIOXID REDOX SIGN, V24, P548, DOI 10.1089/ars.2015.6508
   Endo K, 2006, J ATHEROSCLER THROMB, V13, P68, DOI 10.5551/jat.13.68
   Gandhi G., 2012, Res. J. Biol, V2, P37
   Klaunig JE, 2004, ANNU REV PHARMACOL, V44, P239, DOI 10.1146/annurev.pharmtox.44.101802.121851
   Kuo HW, 2007, MUTAT RES-GEN TOX EN, V631, P62, DOI 10.1016/j.mrgentox.2007.04.009
   Lee J, 2005, HYPERTENSION, V45, P986, DOI 10.1161/01.HYP.0000164569.63160.24
   Leinonen J, 1997, FEBS LETT, V417, P150, DOI 10.1016/S0014-5793(97)01273-8
   Yubero-Serrano EM, 2013, EXP MOL MED, V45, DOI 10.1038/emm.2013.53
   Matés JM, 2000, INT J BIOCHEM CELL B, V32, P157, DOI 10.1016/S1357-2725(99)00088-6
   Mohanty P, 2000, J CLIN ENDOCR METAB, V85, P2970, DOI 10.1210/jc.85.8.2970
   REZNICK AZ, 1992, BIOCHEM J, V286, P607, DOI 10.1042/bj2860607
   Smith K, DNA DOUBLE STRAND BR
   Tarpey MM, 2004, AM J PHYSIOL-REG I, V286, pR431, DOI 10.1152/ajpregu.00361.2003
   Tsilimingas N, 2004, HANDB EXP PHARM, V163/2, P3
   Wachtel-Galor S., 2011, HERBAL MED INTRO ITS, DOI [10.1201/b10787, DOI 10.1201/B10787]
   Wang T, 2011, CANCER EPIDEM BIOMAR, V20, P971, DOI 10.1158/1055-9965.EPI-10-1222
   WANG WT, 2015, EXPERT 3P2N THER TAR, P13
   WANG ZY, 1995, J PHARMACOL EXP THER, V275, P94
   Witko-Sarsat V, 1999, NEPHROL DIAL TRANSPL, V14, P76, DOI 10.1093/ndt/14.suppl_1.76
   Youn JY, 2014, DIABETES, V63, P2344, DOI 10.2337/db13-0719
   Young IS, 2001, J CLIN PATHOL, V54, P339, DOI 10.1136/jcp.54.5.339
   2007, CANCER, V109, P574, DOI DOI 10.1002/CNCR.22417
   2002, AM J CLIN NUTR, V75, P767
NR 37
TC 6
Z9 6
U1 0
U2 3
PU NATL INST SCIENCE COMMUNICATION-NISCAIR
PI NEW DELHI
PA DR K S KRISHNAN MARG, PUSA CAMPUS, NEW DELHI 110 012, INDIA
SN 0301-1208
EI 0975-0959
J9 INDIAN J BIOCHEM BIO
JI Indian J. Biochem. Biophys.
PD APR
PY 2019
VL 56
IS 2
BP 155
EP 161
PG 7
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA HW6QW
UT WOS:000466816200008
DA 2025-06-11
ER

PT J
AU Musso, G
   Paschetta, E
   Gambino, R
   Cassader, M
   Molinaro, F
AF Musso, Giovanni
   Paschetta, Elena
   Gambino, Roberto
   Cassader, Maurizio
   Molinaro, Federica
TI Interactions among bone, liver, and adipose tissue predisposing to
   diabesity and fatty liver
SO TRENDS IN MOLECULAR MEDICINE
LA English
DT Review
ID SERUM OSTEOCALCIN LEVELS; ENDOPLASMIC-RETICULUM STRESS;
   NECROSIS-FACTOR-ALPHA; FETUIN-A; INSULIN-RESISTANCE; MINERAL DENSITY;
   RECEPTOR ACTIVATOR; NONALCOHOLIC STEATOHEPATITIS;
   HEPATOCELLULAR-CARCINOMA; METABOLIC SYNDROME
AB Growing epidemiological evidence connects obesity and its complications, including metabolic syndrome, diabetes, and nonalcoholic fatty liver disease (NAFLD) to reduced bone health and osteoporosis. Parallel to human studies, experimental data disclosed a complex network of interaction among adipose tissue, the liver, and the bone, which reciprocally modulate the function of each other. The main mediators of such crosstalk include hormonal/cytokine signals from the bone (osteopontin, osteocalcin, and osteoprotegerin), the liver (fetuin-A), and adipose tissue [leptin, tumor necrosis factor-alpha (TNF-alpha), and adiponectin]. Dysregulation of this network promotes the development of diabesity, NAFLD, and osteoporosis. We will review recent advances in understanding the mechanisms of bone-liver-adipose tissue interaction predisposing to obesity, diabetes, NAFLD, and osteoporosis and their potential clinical implications.
C1 [Musso, Giovanni] Univ Turin, Gradenigo Hosp, Turin, Italy.
   [Paschetta, Elena; Gambino, Roberto; Cassader, Maurizio; Molinaro, Federica] Univ Turin, San Giovanni Battista Hosp, Dept Med Sci, Turin, Italy.
C3 University of Turin; Humanitas Hospital Gradenigo; University of Turin;
   A.O.U. Citta della Salute e della Scienza di Torino; AOU San Giovanni
   Battista-Molinette
RP Musso, G (corresponding author), Univ Turin, Gradenigo Hosp, Turin, Italy.
EM giovanni_musso@yahoo.it
RI Musso, Giovanni/AAB-7884-2022; GAMBINO, Roberto/AAC-7517-2022
CR Abseyi N, 2012, J CLIN RES PEDIATR E, V4, P182, DOI [10.4274/jcrpe.831, 10.4274/Jcrpe.831]
   Alaaeddine N, 2012, EUR CYTOKINE NETW, V23, P107, DOI 10.1684/ecn.2012.0313
   Aller R, 2011, ANN HEPATOL, V10, P50, DOI 10.1016/S1665-2681(19)31587-X
   Amitani M, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00051
   Ashley DT, 2011, METABOLISM, V60, P994, DOI 10.1016/j.metabol.2010.10.001
   Bao YQ, 2013, J CLIN ENDOCR METAB, V98, P345, DOI 10.1210/jc.2012-2906
   Beck GR, 2013, TRANSL RES, V161, P145, DOI 10.1016/j.trsl.2012.08.006
   Bertola A, 2009, DIABETES, V58, P125, DOI 10.2337/db08-0400
   Bhattacharya SD, 2010, SURGERY, V148, P291, DOI 10.1016/j.surg.2010.05.007
   Binkert C, 1999, J BIOL CHEM, V274, P28514, DOI 10.1074/jbc.274.40.28514
   Biver E, 2011, J CLIN ENDOCR METAB, V96, P2703, DOI 10.1210/jc.2011-0047
   Bulló M, 2012, AM J CLIN NUTR, V95, P249, DOI 10.3945/ajcn.111.016642
   Calton EK, 2013, EUR J CLIN NUTR, V67, P485, DOI 10.1038/ejcn.2013.1
   Campos R.M., 2013, J PEDIAT ENDOCRINOL, V22, P1
   Campos RMS, 2012, ENDOCRINE, V42, P146, DOI 10.1007/s12020-012-9613-3
   Cao DX, 2012, WORLD J GASTROENTERO, V18, P3923, DOI 10.3748/wjg.v18.i30.3923
   Chae S, 2009, INT J ONCOL, V35, P1409, DOI 10.3892/ijo_00000458
   Chang IC, 2010, OSTEOPOROSIS INT, V21, P1401, DOI 10.1007/s00198-009-1107-7
   Chapman J, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013959
   Chen RX, 2011, ONCOL REP, V25, P803, DOI 10.3892/or.2010.1116
   Chiang TI, 2011, OSTEOPOROSIS INT, V22, P577, DOI 10.1007/s00198-010-1327-x
   Confavreux CB, 2011, KIDNEY INT, V79, pS14, DOI 10.1038/ki.2011.25
   de Paula FJA, 2010, DIABETES-METAB RES, V26, P622, DOI 10.1002/dmrr.1135
   DeMambro VE, 2012, J BONE MINER RES, V27, P390, DOI 10.1002/jbmr.545
   Dong QZ, 2013, HEPATOLOGY, V57, P1024, DOI 10.1002/hep.26103
   Magalhaes KBD, 2013, ANN NUTR METAB, V62, P183, DOI 10.1159/000342561
   Dou JX, 2013, CLIN EXP PHARMACOL P, V40, P282, DOI 10.1111/1440-1681.12063
   Ducy P, 1996, NATURE, V382, P448, DOI 10.1038/382448a0
   Ducy P, 2000, CELL, V100, P197, DOI 10.1016/S0092-8674(00)81558-5
   Ebihara K, 2007, J CLIN ENDOCR METAB, V92, P532, DOI 10.1210/jc.2006-1546
   Federico A, 2010, WORLD J GASTROENTERO, V16, P4762, DOI 10.3748/wjg.v16.i38.4762
   Fernández-Real JM, 2010, OSTEOPOROSIS INT, V21, P2101, DOI 10.1007/s00198-010-1174-9
   Ferron M, 2008, P NATL ACAD SCI USA, V105, P5266, DOI 10.1073/pnas.0711119105
   Ferron M, 2012, BONE, V50, P568, DOI 10.1016/j.bone.2011.04.017
   Ferron M, 2010, CELL, V142, P296, DOI 10.1016/j.cell.2010.06.003
   Fulzele K, 2010, CELL, V142, P309, DOI 10.1016/j.cell.2010.06.002
   Gambino R, 2011, ANTIOXID REDOX SIGN, V15, P1325, DOI 10.1089/ars.2009.3058
   Gimba ER, 2013, CANCER LETT, V331, P11, DOI 10.1016/j.canlet.2012.12.003
   Greco EA, 2013, WORLD J DIABETES, V4, P31, DOI 10.4239/wjd.v4.i2.31
   Harslof T, 2011, HORM METAB RES, V43, P477, DOI 10.1055/s-0031-1277156
   Haukeland JW, 2012, EUR J ENDOCRINOL, V166, P503, DOI 10.1530/EJE-11-0864
   Hedbacker K, 2010, CELL METAB, V11, P11, DOI 10.1016/j.cmet.2009.11.007
   Hellmann M, 2012, TRENDS CARDIOVAS MED, V22, P197, DOI 10.1016/j.tcm.2012.07.020
   Hennige AM, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001765
   Herrmann M, 2012, CIRC RES, V111, P575, DOI 10.1161/CIRCRESAHA.111.261479
   Huynh FK, 2013, HEPATOLOGY, V57, P543, DOI 10.1002/hep.26043
   Iki M, 2012, OSTEOPOROSIS INT, V23, P761, DOI 10.1007/s00198-011-1600-7
   Imajo K, 2012, CELL METAB, V16, P44, DOI 10.1016/j.cmet.2012.05.012
   Ix JH, 2009, J BONE MINER RES, V24, P514, DOI 10.1359/JBMR.081017
   Jahnen-Dechent W, 2011, CIRC RES, V108, P1494, DOI 10.1161/CIRCRESAHA.110.234260
   Jeon YK, 2011, ENDOCR J, V58, P87, DOI 10.1507/endocrj.K10E-297
   Johansson H, 2012, J BONE MINER RES, V27, P1390, DOI 10.1002/jbmr.1591
   Kahraman A., 2013, CLIN SCI LOND
   Kalra SP, 2011, GENE THER, V18, P319, DOI 10.1038/gt.2010.164
   Kanazawa I, 2010, METABOLISM, V59, P1252, DOI 10.1016/j.metabol.2009.11.017
   Kawai VK, 2012, CURR OPIN RHEUMATOL, V24, P576, DOI 10.1097/BOR.0b013e328356d212
   Kennedy OD, 2009, J ORTHOP RES, V27, P303, DOI 10.1002/jor.20750
   Kiechl S, 2013, NAT MED, V19, P358, DOI 10.1038/nm.3084
   Kiefer FW, 2011, DIABETOLOGIA, V54, P2132, DOI 10.1007/s00125-011-2170-0
   Kiefer FW, 2010, DIABETES, V59, P935, DOI 10.2337/db09-0404
   Kim HY, 2010, CALCIFIED TISSUE INT, V86, P350, DOI 10.1007/s00223-010-9347-2
   Kleyer A, 2012, J BONE MINER RES, V27, P2442, DOI 10.1002/jbmr.1702
   Koca SS, 2008, INFLAMMATION, V31, P91, DOI 10.1007/s10753-007-9053-z
   Kode A, 2012, J BIOL CHEM, V287, P8757, DOI 10.1074/jbc.M111.282897
   Lee HL, 2010, EXP MOL MED, V42, P437, DOI 10.3858/emm.2010.42.6.045
   Lee JH, 2006, J CLIN ENDOCR METAB, V91, P2605, DOI 10.1210/jc.2005-1545
   Li M, 2012, J CLIN ENDOCR METAB, V97, P2033, DOI 10.1210/jc.2011-3010
   Lima-Cabello E, 2011, CLIN SCI, V120, P239, DOI 10.1042/CS20100387
   Luo XH, 2006, J BONE MINER RES, V21, P1648, DOI 10.1359/JBMR.060707
   Machado MV, 2012, EUR J GASTROEN HEPAT, V24, P1166, DOI 10.1097/MEG.0b013e32835609b0
   Mathews ST, 2006, BIOCHEM BIOPH RES CO, V350, P437, DOI 10.1016/j.bbrc.2006.09.071
   McClung MR, 2006, NEW ENGL J MED, V354, P821, DOI 10.1056/NEJMoa044459
   Mezquita-Raya P, 2005, OSTEOPOROSIS INT, V16, P1368, DOI 10.1007/s00198-005-1844-1
   Minokoshi Y, 2002, NATURE, V415, P339, DOI 10.1038/415339a
   Miyamoto L, 2012, J BIOL CHEM, V287, P40441, DOI 10.1074/jbc.M112.384545
   Mizokami A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057375
   Moon SS, 2012, ENDOCRINE, V42, P423, DOI 10.1007/s12020-012-9639-6
   Morcov C, 2012, MED-SURG J, V116, P785
   Mori K, 2008, METABOLISM, V57, P1248, DOI 10.1016/j.metabol.2008.04.019
   Mori K, 2012, DIABETOL METAB SYNDR, V4, DOI 10.1186/1758-5996-4-53
   Mori K, 2011, RECENT PATENTS ENDOC, V5, P124, DOI 10.2174/187221411799015372
   Movahed A, 2012, J BONE MINER METAB, V30, P683, DOI 10.1007/s00774-012-0367-z
   Musso G, 2012, DIABETOLOGIA, V55, P885, DOI 10.1007/s00125-011-2446-4
   Musso G, 2013, PROG LIPID RES, V52, P175, DOI 10.1016/j.plipres.2012.11.002
   Musso G, 2012, HEPATOLOGY, V56, P933, DOI 10.1002/hep.25739
   Musso G, 2010, ANNU REV MED, V61, P375, DOI 10.1146/annurev.med.60.101107.134820
   Nabipour I, 2010, METABOLISM, V59, P742, DOI 10.1016/j.metabol.2009.09.019
   Nanes MS, 2003, GENE, V321, P1, DOI 10.1016/S0378-1119(03)00841-2
   Ngarmukos C, 2012, CLIN ENDOCRINOL, V77, P42, DOI 10.1111/j.1365-2265.2011.04215.x
   Ochi H, 2010, J ORTHOP RES, V28, P657, DOI 10.1002/jor.21028
   Oosterwerff MM, 2013, CLIN ENDOCRINOL, V78, P242, DOI 10.1111/j.1365-2265.2012.04391.x
   Ou HY, 2012, ENDOCRINOLOGY, V153, P2974, DOI 10.1210/en.2011-2043
   Ou HY, 2011, CLIN ENDOCRINOL, V75, P450, DOI 10.1111/j.1365-2265.2011.04070.x
   Pal D, 2012, NAT MED, V18, P1279, DOI 10.1038/nm.2851
   Pardee PE, 2012, ALIMENT PHARM THER, V35, P248, DOI 10.1111/j.1365-2036.2011.04924.x
   Pepene CE, 2011, EUR J ENDOCRINOL, V164, P61, DOI 10.1530/EJE-10-0720
   Pi M, 2012, ENDOCRINOLOGY, V153, P2062, DOI 10.1210/en.2011-2117
   Pi M, 2011, J BONE MINER RES, V26, P1680, DOI 10.1002/jbmr.390
   Pirgon O, 2011, CLIN ENDOCRINOL, V75, P189, DOI 10.1111/j.1365-2265.2011.04038.x
   Pluskiewicz W, 2012, ENDOKRYNOL POL, V63, P427
   Price PA, 2009, J BIOL CHEM, V284, P17092, DOI 10.1074/jbc.M109.007013
   Rached MT, 2010, J CLIN INVEST, V120, P357, DOI 10.1172/JCI39901
   Rasul S, 2012, CLIN ENDOCRINOL, V76, P499, DOI 10.1111/j.1365-2265.2011.04246.x
   Reid P, 2009, EUR J CELL BIOL, V88, P1, DOI 10.1016/j.ejcb.2008.06.004
   Schafer AL, 2011, J CLIN ENDOCR METAB, V96, pE1982, DOI 10.1210/jc.2011-0587
   Schneeweis LA, 2005, J BIOL CHEM, V280, P41155, DOI 10.1074/jbc.M506366200
   Scholtysek C, 2013, NAT MED, V19, P608, DOI 10.1038/nm.3146
   Seto J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047338
   Siddiq A, 2005, DIABETES, V54, P2477, DOI 10.2337/diabetes.54.8.2477
   St-Pierre J, 2012, CELL METAB, V15, P292, DOI 10.1016/j.cmet.2012.02.004
   Stefan N, 2006, DIABETES CARE, V29, P853, DOI 10.2337/diacare.29.04.06.dc05-1938
   Stern A, 2007, EUR J ENDOCRINOL, V156, P555, DOI 10.1530/EJE-06-0753
   Sun BS, 2008, HEPATOLOGY, V48, P1834, DOI 10.1002/hep.22531
   Sun Q, 2013, DIABETES, V62, P49, DOI 10.2337/db12-0372
   Syn WK, 2012, GUT, V61, P1323, DOI 10.1136/gutjnl-2011-301857
   Syn WK, 2011, HEPATOLOGY, V53, P106, DOI 10.1002/hep.23998
   Takeda S, 2002, CELL, V111, P305, DOI 10.1016/S0092-8674(02)01049-8
   Tenta R, 2012, J ENDOCRINOL INVEST, V35, P306, DOI 10.3275/7744
   Tilg H, 2010, HEPATOLOGY, V52, P1836, DOI 10.1002/hep.24001
   Toroian D, 2008, CALCIFIED TISSUE INT, V82, P116, DOI 10.1007/s00223-007-9085-2
   Tsuji K, 2010, J BONE MINER RES, V25, P1711, DOI 10.1002/jbmr.65
   Tu QS, 2011, J BIOL CHEM, V286, DOI 10.1074/jbc.M110.152405
   Urtasun R, 2012, HEPATOLOGY, V55, P594, DOI 10.1002/hep.24701
   Vijayan V, 2013, FREE RADICAL BIO MED, V61, P72, DOI 10.1016/j.freeradbiomed.2013.03.004
   Wang QP, 2012, BONE, V51, P515, DOI 10.1016/j.bone.2012.05.011
   Weber GF, 2010, BRIT J CANCER, V103, P861, DOI 10.1038/sj.bjc.6605834
   Williams GA, 2009, ENDOCRINOLOGY, V150, P3603, DOI 10.1210/en.2008-1639
   Xu AM, 2003, J CLIN INVEST, V112, P91, DOI 10.1172/JCI200317797
   Xu Y, 2011, ATHEROSCLEROSIS, V216, P180, DOI 10.1016/j.atherosclerosis.2011.01.020
   Yadav VK, 2009, CELL, V138, P976, DOI 10.1016/j.cell.2009.06.051
   Yang SY, 2011, J BIOL CHEM, V286, P19149, DOI 10.1074/jbc.M110.197905
   Yilmaz Y, 2013, DIGEST LIVER DIS, V45, P58, DOI 10.1016/j.dld.2012.08.017
   Yilmaz Y, 2011, SCAND J CLIN LAB INV, V71, P631, DOI 10.3109/00365513.2011.604427
   Yilmaz Y, 2010, SCAND J CLIN LAB INV, V70, P541, DOI 10.3109/00365513.2010.524933
   Yilmaz Y, 2010, ANN CLIN BIOCHEM, V47, P549, DOI 10.1258/acb.2010.010169
   Zeadin MG, 2012, BIOCHEM BIOPH RES CO, V425, P924, DOI 10.1016/j.bbrc.2012.08.011
   Zeyda M, 2011, ENDOCRINOLOGY, V152, P2219, DOI 10.1210/en.2010-1328
   Zhang W, 2013, INT J BIOCHEM CELL B, V45, P736, DOI 10.1016/j.biocel.2012.12.019
   Zhao J, 2008, GASTROENTEROLOGY, V135, P956, DOI 10.1053/j.gastro.2008.05.025
   Zhou B, 2013, ENDOCRINOLOGY, V154, P1055, DOI 10.1210/en.2012-2144
   Zou W, 2001, J CELL BIOCHEM, V83, P70, DOI 10.1002/jcb.1202
NR 141
TC 73
Z9 87
U1 0
U2 34
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1471-4914
EI 1471-499X
J9 TRENDS MOL MED
JI Trends Mol. Med
PD SEP
PY 2013
VL 19
IS 9
BP 522
EP 535
DI 10.1016/j.molmed.2013.05.006
PG 14
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
   Medicine
GA 226TJ
UT WOS:000325058600003
PM 23816817
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Bánhegyi, G
   Csala, M
   Benedetti, A
AF Banhegyi, Gabor
   Csala, Miklos
   Benedetti, Angelo
TI Hexose-6-phosphate dehydrogenase: linking endocrinology and metabolism
   in the endoplasmic reticulum
SO JOURNAL OF MOLECULAR ENDOCRINOLOGY
LA English
DT Review
ID PITUITARY-ADRENAL AXIS; FATTY-ACID CYCLE; 11-BETA-HYDROXYSTEROID
   DEHYDROGENASE; ADIPOSE-TISSUE; PYRIDINE-NUCLEOTIDES; NADPH/NADP(+)
   RATIO; PANCREATIC-ISLETS; TYPE-1 ACTIVITY; ER STRESS; GLUCOSE
AB Hexose-6-phosphate dehydrogenase (H6PD) got into the focus of interest due to its role in the prereceptorial activation of glucocorticoids, which has been implicated in the pathomechanism of metabolic syndrome. Genetic observations, results gained in H6PD knockout mice, and studies on differentiating adipocytes demonstrated the importance of the enzyme in metabolic regulation. A nutrient-sensing function can be postulated for the enzyme, which links metabolism to endocrinology in the endoplasmic reticulum. This review provides an overview of the recent developments concerning the enzyme and its impact on various branches of the intermediary metabolism, which make it an important subject for the research on obesity, diabetes, and metabolic syndrome. Journal of Molecular Endocrinology (2009) 42, 283-289
C1 [Banhegyi, Gabor; Benedetti, Angelo] Univ Siena, Dipartimento Fisiopatol Med Sperimentale & Sanita, I-53100 Siena, Italy.
   [Banhegyi, Gabor; Csala, Miklos] Semmelweis Univ, Dept Med Chem Mol Biol & Pathobiochem, H-1444 Budapest, Hungary.
   [Banhegyi, Gabor; Csala, Miklos] MTA SE Pathobiochem Res Grp, H-1444 Budapest, Hungary.
C3 University of Siena; Semmelweis University; Semmelweis University
RP Benedetti, A (corresponding author), Univ Siena, Dipartimento Fisiopatol Med Sperimentale & Sanita, Via Aldo Moro, I-53100 Siena, Italy.
EM benedetti@unisi.it
RI Csala, Miklos/H-5369-2011; Bánhegyi, Gábor/A-1476-2014
OI Csala, Miklos/0000-0002-3829-4361
CR Atanasov AG, 2004, FEBS LETT, V571, P129, DOI 10.1016/j.febslet.2004.06.065
   Atanasov AG, 2008, BBA-MOL CELL RES, V1783, P1536, DOI 10.1016/j.bbamcr.2008.03.001
   Balázs Z, 2009, MOL CELL ENDOCRINOL, V301, P117, DOI 10.1016/j.mce.2008.10.021
   Bánhegyi G, 2004, J BIOL CHEM, V279, P27017, DOI 10.1074/jbc.M404159200
   Bánhegyi G, 2007, FEBS LETT, V581, P3634, DOI 10.1016/j.febslet.2007.04.028
   Basu R, 2006, DIABETES, V55, P667, DOI 10.2337/diabetes.55.03.06.db05-1335
   Belkaid A, 2006, FEBS LETT, V580, P3746, DOI 10.1016/j.febslet.2006.05.071
   BEUTLER E, 1967, J BIOL CHEM, V242, P5289
   Bujalska IJ, 2005, J MOL ENDOCRINOL, V34, P675, DOI 10.1677/jme.1.01718
   Bujalska IJ, 2008, ENDOCRINOLOGY, V149, P2584, DOI 10.1210/en.2007-1705
   Chang-Chen KJ, 2008, REV ENDOCR METAB DIS, V9, P329, DOI 10.1007/s11154-008-9101-5
   Chapman KE, 2008, NEUROCHEM RES, V33, P624, DOI 10.1007/s11064-007-9504-9
   Clarke JL, 2003, ARCH BIOCHEM BIOPHYS, V415, P229, DOI 10.1016/S0003-9861(03)00229-7
   Collard F, 1999, FEBS LETT, V459, P223, DOI 10.1016/S0014-5793(99)01247-8
   Csala M, 2006, FEBS LETT, V580, P2160, DOI 10.1016/j.febslet.2006.03.050
   Czegle I, 2006, MOL CELL ENDOCRINOL, V248, P24, DOI 10.1016/j.mce.2005.10.018
   DENTON RM, 1966, BIOCHEM J, V100, P407, DOI 10.1042/bj1000407
   Díaz-Flores M, 2006, LIFE SCI, V78, P2601, DOI 10.1016/j.lfs.2005.10.022
   Dimitriadis G, 1997, BIOCHEM J, V321, P707, DOI 10.1042/bj3210707
   DZYAKANCHUK AA, 2008, MOL CELL ENDOCRINOL, DOI DOI 10.1016/JMCE.2008.08.009
   HEMS DA, 1971, BIOCHEM J, V123, P391, DOI 10.1042/bj1230391
   Hewitt KN, 2005, ENDOCRINOLOGY, V146, P2539, DOI 10.1210/en.2005-0117
   Hotamisligil GS, 2005, DIABETES, V54, pS73, DOI 10.2337/diabetes.54.suppl_2.S73
   Hou ZQ, 2008, MOL CELL ENDOCRINOL, V291, P71, DOI 10.1016/j.mce.2008.03.004
   Hult M, 2004, CELL MOL LIFE SCI, V61, P992, DOI 10.1007/s00018-003-3476-y
   Kardon T, 2008, FEBS LETT, V582, P1809, DOI 10.1016/j.febslet.2008.04.045
   Lavery GG, 2008, J BIOL CHEM, V283, P8453, DOI 10.1074/jbc.M710067200
   Lavery GG, 2007, ENDOCRINOLOGY, V148, P6100, DOI 10.1210/en.2007-0963
   Lavery GG, 2006, J BIOL CHEM, V281, P6546, DOI 10.1074/jbc.M512635200
   Leuzzi R, 2003, BLOOD, V101, P2381, DOI 10.1182/blood-2002-08-2576
   Lewis-Tuffin LJ, 2006, ANN NY ACAD SCI, V1069, P1, DOI 10.1196/annals.1351.001
   Luu-The V, 2001, J STEROID BIOCHEM, V76, P143, DOI 10.1016/S0960-0760(00)00155-2
   Marcolongo P, 2007, ENDOCRINOLOGY, V148, P2487, DOI 10.1210/en.2006-1472
   Mason PJ, 1999, BLOOD CELL MOL DIS, V25, P30, DOI 10.1006/bcmd.1999.0224
   Morton NM, 2008, FRONT HORM RES, V36, P146, DOI 10.1159/000115363
   Mziaut H, 1999, J BIOL CHEM, V274, P14122, DOI 10.1074/jbc.274.20.14122
   Nashev LG, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000561
   Odermatt A, 1999, J BIOL CHEM, V274, P28762, DOI 10.1074/jbc.274.40.28762
   OKA KI, 1981, BIOCHIM BIOPHYS ACTA, V662, P318, DOI 10.1016/0005-2744(81)90045-0
   OZOLS J, 1995, J BIOL CHEM, V270, P2305, DOI 10.1074/jbc.270.5.2305
   OZOLS J, 1993, P NATL ACAD SCI USA, V90, P5302, DOI 10.1073/pnas.90.11.5302
   Panten U, 2008, DIABETOLOGIA, V51, P101, DOI 10.1007/s00125-007-0849-z
   Piccirella S, 2006, J BIOL CHEM, V281, P4671, DOI 10.1074/jbc.M509406200
   Pierotti S, 2008, J STEROID BIOCHEM, V108, P292, DOI 10.1016/j.jsbmb.2007.09.018
   Pollak N, 2007, BIOCHEM J, V402, P205, DOI 10.1042/BJ20061638
   RANDLE PJ, 1963, LANCET, V1, P785
   Randle PJ, 1998, DIABETES METAB REV, V14, P263, DOI 10.1002/(SICI)1099-0895(199812)14:4<263::AID-DMR233>3.0.CO;2-C
   RIZZA RA, 1982, J CLIN ENDOCR METAB, V54, P131, DOI 10.1210/jcem-54-1-131
   Rogoff D, 2007, ENDOCRINOLOGY, V148, P5072, DOI 10.1210/en.2007-0593
   Schweizer RAS, 2004, J BIOL CHEM, V279, P18415, DOI 10.1074/jbc.M313615200
   Sekar N, 1998, ENDOCRINOLOGY, V139, P2514, DOI 10.1210/en.139.5.2514
   Stahn C, 2007, MOL CELL ENDOCRINOL, V275, P71, DOI 10.1016/j.mce.2007.05.019
   Stimson R H, 2007, Minerva Endocrinol, V32, P141
   Swali A, 2008, DIABETOLOGIA, V51, P2003, DOI 10.1007/s00125-008-1137-2
   Tomlinson JW, 2008, DIABETES, V57, P1536, DOI 10.2337/db08-0094
   Tomlinson JW, 2004, ENDOCR REV, V25, P831, DOI 10.1210/er.2003-0031
   Van Schaftingen E, 2002, BIOCHEM J, V362, P513, DOI 10.1042/0264-6021:3620513
   Wake DJ, 2006, J CLIN ENDOCR METAB, V91, P4682, DOI 10.1210/jc.2006-0819
   Walker EA, 2007, J BIOL CHEM, V282, P27030, DOI 10.1074/jbc.M704144200
   Wamil M, 2008, ENDOCRINOLOGY, V149, P5909, DOI 10.1210/en.2008-0420
   Wang HY, 2005, J CELL SCI, V118, P3905, DOI 10.1242/jcs.02513
   Wei YR, 2006, AM J PHYSIOL-ENDOC M, V291, pE275, DOI 10.1152/ajpendo.00644.2005
   White PC, 2008, CURR OPIN PEDIATR, V20, P453, DOI 10.1097/MOP.0b013e328305e439
   White PC, 2007, MOL CELL ENDOCRINOL, V265, P89, DOI 10.1016/j.mce.2006.12.022
   Yoshida H, 2007, FEBS J, V274, P630, DOI 10.1111/j.1742-4658.2007.05639.x
   Zhang KZ, 2008, NATURE, V454, P455, DOI 10.1038/nature07203
NR 66
TC 32
Z9 39
U1 0
U2 5
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0952-5041
EI 1479-6813
J9 J MOL ENDOCRINOL
JI J. Mol. Endocrinol.
PD MAR-APR
PY 2009
VL 42
IS 3-4
BP 283
EP 289
DI 10.1677/JME-08-0156
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 530ZA
UT WOS:000272630300010
PM 19060178
DA 2025-06-11
ER

PT J
AU Kondo, S
   Kamei, A
   Xiao, JZ
   Iwatsuki, K
   Abe, K
AF Kondo, S.
   Kamei, A.
   Xiao, J. Z.
   Iwatsuki, K.
   Abe, K.
TI Bifidobacterium breve B-3 exerts metabolic syndrome-suppressing
   effects in the liver of diet-induced obese mice: a DNA microarray
   analysis
SO BENEFICIAL MICROBES
LA English
DT Article
DE Bifidobacterium breve; anti-obesity; gene expressions
ID GUT MICROBIOTA; INDUCED INFLAMMATION; LINOLEIC-ACID; FATTY-ACIDS;
   ANTIOBESITY; EXPRESSION
AB We previously reported that supplementation with Bifidobacterium breve B-3 reduced body weight gain and accumulation of visceral fat in a dose-dependent manner, and improved serum levels of total cholesterol, glucose and insulin in a mouse model of diet-induced obesity. In this study, we investigated the expression of genes in the liver using DNA microarray analysis and q-PCR to reveal the mechanism of these anti-obesity effects in this mouse model. Administration of B. breve B-3 led to regulated gene expression of pathways involved in lipid metabolism and response to stress. The results indicate that these regulations in the liver are related to the anti-metabolic syndrome effects of B. breve B-3.
C1 [Abe, K.] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Appl Biol Chem, Bunkyo Ku, Tokyo 1138657, Japan.
C3 University of Tokyo
EM j_xiao@morinagamilk.co.jp
RI Xiao, Jinzhong/HIR-9791-2022; Kamei, Asuka/GXH-4934-2022
FU Grants-in-Aid for Scientific Research [23248058, 25560046] Funding
   Source: KAKEN
CR An HM, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-116
   Bäckhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Chen ZX, 2007, BIOINFORMATICS, V23, P321, DOI 10.1093/bioinformatics/btl609
   Chiba T, 2011, ARTERIOSCL THROM VAS, V31, P1326, DOI 10.1161/ATVBAHA.111.226159
   Cho HP, 1999, J BIOL CHEM, V274, P471, DOI 10.1074/jbc.274.1.471
   Fournier T, 2000, BBA-PROTEIN STRUCT M, V1482, P157, DOI 10.1016/S0167-4838(00)00153-9
   Gentleman RC, 2004, GENOME BIOL, V5, DOI 10.1186/gb-2004-5-10-r80
   Kadooka Y, 2010, EUR J CLIN NUTR, V64, P636, DOI 10.1038/ejcn.2010.19
   Kondo S, 2010, BIOSCI BIOTECH BIOCH, V74, P1656, DOI 10.1271/bbb.100267
   Lee K, 2007, J APPL MICROBIOL, V103, P1140, DOI 10.1111/j.1365-2672.2007.03336.x
   Leonard AE, 2002, LIPIDS, V37, P733, DOI 10.1007/s11745-002-0955-6
   Li JJ, 2008, MOL NUTR FOOD RES, V52, P631, DOI 10.1002/mnfr.200700399
   Osei-Hyiaman D., 2009, PPAR RES, V2009
   Richardson TA, 2005, J PHARMACOL EXP THER, V314, P703, DOI 10.1124/jpet.105.085456
   Sears B, 2012, EUR REV MED PHARMACO, V16, P1137
   Takemura N, 2010, EXP BIOL MED, V235, P849, DOI 10.1258/ebm.2010.009377
   Theken KN, 2011, DRUG METAB DISPOS, V39, P22, DOI 10.1124/dmd.110.035287
   Tvrdik P, 2000, J CELL BIOL, V149, P707, DOI 10.1083/jcb.149.3.707
   Westerberg R, 2004, J BIOL CHEM, V279, P5621, DOI 10.1074/jbc.M310529200
NR 22
TC 28
Z9 29
U1 0
U2 19
PU WAGENINGEN ACADEMIC PUBLISHERS
PI WAGENINGEN
PA PO BOX 220, WAGENINGEN, 6700 AE, NETHERLANDS
SN 1876-2883
EI 1876-2891
J9 BENEF MICROBES
JI Benef. Mirbobes
PD SEP
PY 2013
VL 4
IS 3
BP 247
EP 251
DI 10.3920/BM2012.0019
PG 5
WC Microbiology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology; Nutrition & Dietetics
GA 200ER
UT WOS:000323051100005
PM 23666099
DA 2025-06-11
ER

PT J
AU Basu, A
   Devaraj, S
   Jialal, I
AF Basu, A
   Devaraj, S
   Jialal, I
TI Dietary factors that promote or retard inflammation
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Review
DE C-reactive protein; diet; inflammation; macronutrients; micronutrients;
   weight loss
ID C-REACTIVE PROTEIN; ALPHA-LINOLENIC ACID; N-3 FATTY-ACIDS; RISK-FACTORS;
   FISH-OIL; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; PLASMA BIOMARKERS; OXIDATIVE STRESS
AB Inflammation plays a pivotal role in all stages of atherosclerosis. Cardiovascular risk factors and metabolic syndrome are typified by low-grade inflammation. Intervention trials convincingly demonstrate that weight loss reduces biomarkers of inflammation, such as C-reactive protein (CRP) and interleukin (IL)-6. Limited studies have shown that certain dietary factors; oleic acid, alpha-linolenic acid, and antioxidants RRR-alpha-alpha tocopherol, reduce biomarkers of inflammation. Most of the studies with fish oil supplementation have shown null effects, and conflicting results have been reported with saturated and trans fatty acids, cholesterol, and soy intake. Much further research is needed to define the role of individual dietary factors on the biomarkers of inflammation and the mechanism of the anti-inflammatory effects of weight loss.
C1 Univ Calif Davis, Med Ctr, Lab Atherosclerosis & Metab Res, Sacramento, CA 95817 USA.
C3 University of California System; University of California Davis
RP Univ Calif Davis, Med Ctr, Lab Atherosclerosis & Metab Res, 4635 2nd Ave,Res Bldg 1,Room 3000, Sacramento, CA 95817 USA.
EM ishwarlal.jialal@ucdmc.ucdavis.edu
RI Jialal, Ishwarlal/AAG-6218-2019
FU NCCIH NIH HHS [K24AT00596] Funding Source: Medline; NHLBI NIH HHS
   [HL074360] Funding Source: Medline
CR Baer DJ, 2004, AM J CLIN NUTR, V79, P969
   Bemelmans WJE, 2004, EUR J CLIN NUTR, V58, P1083, DOI 10.1038/sj.ejcn.1601938
   Brighenti F, 2005, BRIT J NUTR, V93, P619, DOI 10.1079/BJN20051400
   Chan DC, 2002, CLIN CHEM, V48, P877
   Church TS, 2003, AM J MED, V115, P702, DOI 10.1016/j.amjmed.2003.08.024
   Ciubotaru I, 2003, J NUTR BIOCHEM, V14, P513, DOI 10.1016/S0955-2863(03)00101-3
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   de Lorgeril M, 1999, CIRCULATION, V99, P779, DOI 10.1161/01.CIR.99.6.779
   Devaraj S, 2004, ENDOCRIN METAB CLIN, V33, P431, DOI 10.1016/j.ecl.2004.03.008
   Dietrich M, 2005, NUTR REV, V63, P22, DOI [10.1111/j.1753-4887.2005.tb00107.x, 10.1301/nr.2004.janr.22-28]
   DOLECEK TA, 1992, P SOC EXP BIOL MED, V200, P177, DOI 10.3181/00379727-200-43413
   Durga J, 2005, ARCH INTERN MED, V165, P1388, DOI 10.1001/archinte.165.12.1388
   Esposito K, 2003, AM J CLIN NUTR, V78, P1135, DOI 10.1093/ajcn/78.6.1135
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   Estruch R, 2004, ATHEROSCLEROSIS, V175, P117, DOI 10.1016/j.atherosclerosis.2004.03.006
   FERRUCCI L, 2005, J CLIN ENDOCRINOL ME
   Friso S, 2001, CIRCULATION, V103, P2788
   Fung TT, 2001, AM J CLIN NUTR, V73, P61
   Geelen A, 2004, EUR J CLIN NUTR, V58, P1440, DOI 10.1038/sj.ejcn.1601986
   Han SN, 2002, J LIPID RES, V43, P445
   Hilpert KF, 2005, J NUTR, V135, P1075, DOI 10.1093/jn/135.5.1075
   Hu FB, 1999, AM J CLIN NUTR, V69, P890
   Jellema A, 2004, EUR J CLIN INVEST, V34, P766, DOI 10.1111/j.1365-2362.2004.01414.x
   Jenkins DJA, 2003, JAMA-J AM MED ASSOC, V290, P502, DOI 10.1001/jama.290.4.502
   Jenkins DJA, 2002, METABOLISM, V51, P919, DOI 10.1053/meta.2002.33352
   Jialal I, 2004, HYPERTENSION, V44, P6, DOI 10.1161/01.HYP.0000130484.20501.df
   JIALAL I, IN PRESS AM J CLIN N
   King DE, 2005, J AM COLL NUTR, V24, P166, DOI 10.1080/07315724.2005.10719461
   King DE, 2003, AM J CARDIOL, V92, P1335, DOI 10.1016/j.amjcard.2003.08.020
   Lee IM, 2005, JAMA-J AM MED ASSOC, V294, P56, DOI 10.1001/jama.294.1.56
   Lee W, 2005, CLIN BIOCHEM, V38, P84, DOI 10.1016/j.clinbiochem.2004.09.024
   Li Z, 2005, EUR J CLIN NUTR, V59, P411, DOI 10.1038/sj.ejcn.1602089
   Libby P, 2002, NATURE, V420, P868, DOI 10.1161/ATVBAHA.108.179705
   Lichtenstein AH, 2003, ATHEROSCLEROSIS, V171, P97, DOI 10.1016/j.atherosclerosis.2003.07.005
   Lopez-Garcia E, 2004, J NUTR, V134, P1806, DOI 10.1093/jn/134.7.1806
   Lopez-Garcia E, 2004, AM J CLIN NUTR, V80, P1029, DOI 10.1093/ajcn/80.4.1029
   Madsen T, 2001, AM J CARDIOL, V88, P1139, DOI 10.1016/S0002-9149(01)02049-5
   MICHALSEN A, 2005, EUR J CLIN NUTR, V23, P1
   Miller ER, 2005, ANN INTERN MED, V142, P37, DOI 10.7326/0003-4819-142-1-200501040-00110
   Moloney F, 2004, AM J CLIN NUTR, V80, P887
   Mori TA, 2003, FREE RADICAL BIO MED, V35, P772, DOI 10.1016/S0891-5849(03)00407-6
   Nappo F, 2002, J AM COLL CARDIOL, V39, P1145, DOI 10.1016/S0735-1097(02)01741-2
   Pawlosky RJ, 2003, AM J CLIN NUTR, V77, P565, DOI 10.1093/ajcn/77.3.565
   Phillips T, 2003, MED SCI SPORT EXER, V35, P2032, DOI 10.1249/01.MSS.0000099112.32342.10
   Pirro M, 2004, EUR J CARDIOV PREV R, V11, P497, DOI 10.1097/00149831-200412000-00009
   Rallidis LS, 2003, ATHEROSCLEROSIS, V167, P237, DOI 10.1016/S0021-9150(02)00427-6
   Risérus U, 2002, CIRCULATION, V106, P1925, DOI 10.1161/01.CIR.0000033589.15413.48
   Shai I, 2004, DIABETOLOGIA, V47, P1760, DOI 10.1007/s00125-004-1526-0
   Simopoulos AP, 1999, AM J CLIN NUTR, V70, p560S, DOI 10.1093/ajcn/70.3.560s
   Singh U, 2004, ANN NY ACAD SCI, V1031, P195, DOI 10.1196/annals.1331.019
   Smedman A, 2005, BRIT J NUTR, V94, P791, DOI 10.1079/BJN20041419
   Tannock LR, 2005, CIRCULATION, V111, P3058, DOI 10.1161/CIRCULATIONAHA.104.506188
   van Herpen-Broekmans WMR, 2004, EUR J EPIDEMIOL, V19, P915, DOI 10.1007/s10654-004-5760-z
   Vega-López S, 2004, METABOLISM, V53, P236, DOI 10.1016/j.metabol.2003.09.012
   Visser M, 1999, JAMA-J AM MED ASSOC, V282, P2131, DOI 10.1001/jama.282.22.2131
   Wells BJ, 2005, NUTRITION, V21, P125, DOI 10.1016/j.nut.2004.03.021
   Zhao GX, 2004, J NUTR, V134, P2991, DOI 10.1093/jn/134.11.2991
   2005, ANN INTERN MED, V143, P150
NR 58
TC 164
Z9 256
U1 0
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD MAY
PY 2006
VL 26
IS 5
BP 995
EP 1001
DI 10.1161/01.ATV.0000214295.86079.d1
PG 7
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 034PF
UT WOS:000236942400008
PM 16484595
OA Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Calvi, P
   Terzo, S
   Amato, A
AF Calvi, Pasquale
   Terzo, Simona
   Amato, Antonella
TI Betalains: colours for human health
SO NATURAL PRODUCT RESEARCH
LA English
DT Article
DE Betalains; metabolic syndrome; obesity; Opuntia ficus indica
ID ATTENUATES OXIDATIVE STRESS; FATTY LIVER-DISEASE; BETA-VULGARIS L.;
   CACTUS PEAR; ANTIOXIDANT ACTIVITY; BEETROOT JUICE; BLOOD-PRESSURE;
   INCREASED RESISTANCE; INSULIN-RESISTANCE; OLDER OVERWEIGHT
AB In the last years, the use of natural phytochemical compounds as protective agents in the prevention and treatment of obesity and the related-metabolic syndrome has gained much attention worldwide. Different studies have shown health benefits for many vegetables such Opuntia ficus-indica and Beta vulgaris and their pigments collectively referred as betalains. Betalains exert antioxidative, anti-inflammation, lipid lowering, antidiabetic and anti-obesity effects. This review summarizes findings in the literature and highlights the therapeutic potential of betalains and their natural source as valid alternative for supplementation in obesity-related disorders treatment. Further research is needed to establish the mechanisms through which these natural pigments exert their beneficial effects and to translate the promising findings from animal models to humans.
C1 [Calvi, Pasquale; Terzo, Simona; Amato, Antonella] Univ Palermo Viale Sci, Dept Biol Chem Pharmaceut Sci & Technol STEBICEF, Palermo, Italy.
   [Calvi, Pasquale] Univ Palermo, Dipartment Biomed Neurosci & Adv Diagnost BiND, Palermo, Italy.
C3 University of Palermo; University of Palermo
RP Amato, A (corresponding author), Univ Palermo Viale Sci, Dept Biol Chem Pharmaceut Sci & Technol STEBICEF, Palermo, Italy.
EM antonella.amato@unipa.it
RI Amato, Antonella/AAX-8821-2020
CR Abderrahim F, 2015, FOOD CHEM, V183, P83, DOI 10.1016/j.foodchem.2015.03.029
   Abedimanesh N, 2021, NUTR METAB, V18, DOI 10.1186/s12986-021-00621-9
   Al-Dosari M, 2011, FARMACIA, V59, P669
   Albano C, 2015, ANTIOXIDANTS-BASEL, V4, P269, DOI 10.3390/antiox4020269
   Guerrero-Rubio MA, 2019, FOOD CHEM, V274, P840, DOI 10.1016/j.foodchem.2018.09.067
   Allegra M, 2014, J NUTR, V144, P185, DOI 10.3945/jn.113.183657
   González-Ponce HA, 2020, FOOD RES INT, V137, DOI 10.1016/j.foodres.2020.109461
   Ashor AW, 2015, J HUM HYPERTENS, V29, P511, DOI 10.1038/jhh.2014.114
   Attanzio A, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/3457846
   Attanzio A, 2018, FOOD NUTR RES, V62, DOI 10.29219/fnr.v62.1262
   Baker RG, 2011, CELL METAB, V13, P11, DOI 10.1016/j.cmet.2010.12.008
   Beals JW, 2017, J NUTR METAB, V2017, DOI 10.1155/2017/6436783
   Budinsky A, 2001, PROSTAG LEUKOTR ESS, V65, P45, DOI 10.1054/plef.2001.0287
   Butera D, 2002, J AGR FOOD CHEM, V50, P6895, DOI 10.1021/jf025696p
   Cai YZ, 2005, J CHROMATOGR SCI, V43, P454, DOI 10.1093/chromsci/43.9.454
   Cai YZ, 2003, J AGR FOOD CHEM, V51, P2288, DOI 10.1021/jf030045u
   Cheok A, 2020, FOOD FUNCT, V11, P6807, DOI [10.1039/d0fo00537a, 10.1039/D0FO00537A]
   Clifford T, 2015, NUTRIENTS, V7, P2801, DOI 10.3390/nu7042801
   Clemente ACE, 2011, TROP J PHARM RES, V10, P595, DOI 10.4314/tjpr.v10i5.8
   El Gamal AA, 2014, MEDIAT INFLAMM, V2014, DOI 10.1155/2014/983952
   Esatbeyoglu T, 2015, MOL NUTR FOOD RES, V59, P36, DOI 10.1002/mnfr.201400484
   Esatbeyoglu T, 2014, FOOD CHEM TOXICOL, V73, P119, DOI 10.1016/j.fct.2014.08.007
   Galati EM, 2005, PHYTOTHER RES, V19, P796, DOI 10.1002/ptr.1741
   Gandía-Herrero F, 2005, FOOD RES INT, V38, P879, DOI 10.1016/j.foodres.2005.01.012
   Gandía-Herrero F, 2016, CRIT REV FOOD SCI, V56, P937, DOI 10.1080/10408398.2012.740103
   Gandía-Herrero F, 2012, J NAT PROD, V75, P1030, DOI 10.1021/np200950n
   Garoby-Salom S, 2016, J PHYSIOL BIOCHEM, V72, P59, DOI 10.1007/s13105-015-0461-5
   Gentile C, 2004, ANN NY ACAD SCI, V1028, P481, DOI 10.1196/annals.1322.057
   Ghissing U, 2023, NAT PROD RES, V37, P529, DOI 10.1080/14786419.2021.1984467
   Hadipour E, 2020, PHYTOTHER RES, V34, P1847, DOI 10.1002/ptr.6653
   Hadipour E, 2020, NEUROCHEM RES, V45, P395, DOI 10.1007/s11064-019-02927-w
   Han JY, 2014, FOOD CHEM TOXICOL, V70, P100, DOI 10.1016/j.fct.2014.04.038
   Herbach KM, 2006, J FOOD SCI, V71, pR41, DOI 10.1111/j.1750-3841.2006.00022.x
   HEUER S, 1992, PHYTOCHEMISTRY, V31, P1801, DOI 10.1016/0031-9422(92)83151-N
   Hobbs DA, 2013, NUTR RES REV, V26, P210, DOI 10.1017/S0954422413000188
   Hobbs DA, 2012, BRIT J NUTR, V108, P2066, DOI 10.1017/S0007114512000190
   Indumathi D, 2017, BIOMED PHARMACOTHER, V88, P1069, DOI 10.1016/j.biopha.2017.01.146
   Angulo-Bejarano PI, 2019, CURR PHARM DESIGN, V25, P3457, DOI 10.2174/1381612825666191010171819
   Jajja A, 2015, P NUTR SOC, V74, pE109, DOI 10.1017/S002966511500124X
   Jerz G, 2008, J CHROMATOGR A, V1190, P63, DOI 10.1016/j.chroma.2008.02.093
   Kanner J, 2001, J AGR FOOD CHEM, V49, P5178, DOI 10.1021/jf010456f
   Keller J, 2015, J PHYSIOL BIOCHEM, V71, P577, DOI 10.1007/s13105-015-0408-x
   Khan MI, 2016, COMPR REV FOOD SCI F, V15, P316, DOI 10.1111/1541-4337.12185
   Khanam UKS, 2013, CAN J PLANT SCI, V93, P47, DOI [10.4141/CJPS2012-117, 10.4141/cjps2012-117]
   Kong MJ, 2021, BIOMED PHARMACOTHER, V133, DOI 10.1016/j.biopha.2020.110975
   KRANTZ C, 1980, FOOD COSMET TOXICOL, V18, P363, DOI 10.1016/0015-6264(80)90190-X
   Kujawska M, 2009, J AGR FOOD CHEM, V57, P2570, DOI 10.1021/jf803315d
   Kumar JK, 2004, NAT PROD RES, V18, P59, DOI 10.1080/1057563031000122112
   Lin SM, 2010, J AGR FOOD CHEM, V58, P10364, DOI 10.1021/jf1017719
   Marchesini G, 2001, DIABETES, V50, P1844, DOI 10.2337/diabetes.50.8.1844
   Martínez EMM, 2021, PLANTS-BASEL, V10, DOI 10.3390/plants10020368
   Miguel MG, 2018, ANTIOXIDANTS-BASEL, V7, DOI 10.3390/antiox7040053
   Mollazadeh H, 2016, IRAN J BASIC MED SCI, V19, P1258, DOI 10.22038/ijbms.2016.7906
   Monteiro R, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/289645
   NNIaBON BH, 2017, Eur. J. Pharm. Med. Res., V4, P60
   Page J, 2000, ARCH INTERN MED, V160, P777, DOI 10.1001/archinte.160.6.777
   Pem D, 2015, IRAN J PUBLIC HEALTH, V44, P1309
   Pietrzkowski Z., 2010, New Medicine, V14, P12
   Rahimi P, 2019, FOOD FUNCT, V10, P8286, DOI [10.1039/c9fo02020a, 10.1039/C9FO02020A]
   Rahimi P, 2019, CRIT REV FOOD SCI, V59, P2949, DOI 10.1080/10408398.2018.1479830
   Rahman K, 2007, CLIN INTERV AGING, V2, P219
   Raish M, 2019, 3 BIOTECH, V9, DOI 10.1007/s13205-019-1677-9
   Raubenheimer K, 2017, NUTRIENTS, V9, DOI 10.3390/nu9111270
   Reddy MK, 2005, J AGR FOOD CHEM, V53, P9268, DOI 10.1021/jf051399j
   Reynoso RC, 1999, FOOD CHEM TOXICOL, V37, P825, DOI 10.1016/S0278-6915(99)00070-8
   de Castro APRB, 2019, PLANT FOOD HUM NUTR, V74, P232, DOI 10.1007/s11130-019-00730-0
   Saani M, 2018, NAT PROD RES, V32, P1208, DOI 10.1080/14786419.2017.1326037
   Sadowska-Bartosz I, 2021, MOLECULES, V26, DOI 10.3390/molecules26092520
   Sakihama Y, 2012, FREE RADICAL RES, V46, P93, DOI 10.3109/10715762.2011.641157
   Díaz MDS, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/8634249
   Serafini M, 2016, CURR PHARM DESIGN, V22, P6701, DOI 10.2174/1381612823666161123094235
   Skalicky M, 2020, MOLECULES, V25, DOI 10.3390/molecules25225395
   Slimen IB, 2017, J AGR FOOD CHEM, V65, P675, DOI 10.1021/acs.jafc.6b04208
   Song HZ, 2016, J GASTROEN HEPATOL, V31, P1462, DOI 10.1111/jgh.13278
   Song HZ, 2016, J AGR FOOD CHEM, V64, P236, DOI 10.1021/acs.jafc.5b05177
   Stintzing FC, 2005, J AGR FOOD CHEM, V53, P442, DOI 10.1021/jf048751y
   Stintzing FC, 2004, TRENDS FOOD SCI TECH, V15, P19, DOI 10.1016/j.tifs.2003.07.004
   Stintzing FC, 2002, J AGR FOOD CHEM, V50, P2302, DOI 10.1021/jf011305f
   Tan DH, 2015, FOOD CHEM TOXICOL, V78, P141, DOI 10.1016/j.fct.2015.01.018
   da Silva DVT, 2019, MOLECULES, V24, DOI 10.3390/molecules24030458
   Terzo S, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11010080
   Tesoriere L, 2005, J AGR FOOD CHEM, V53, P1266, DOI 10.1021/jf048134+
   Tesoriere L, 2004, AM J CLIN NUTR, V80, P941, DOI 10.1093/ajcn/80.4.941
   Tesoriere L, 2014, BRIT J NUTR, V111, P415, DOI 10.1017/S0007114513002663
   Tesoriere L, 2013, EUR J NUTR, V52, P1077, DOI 10.1007/s00394-012-0414-5
   Tesoriere L, 2003, FREE RADICAL RES, V37, P689, DOI 10.1080/1071576031000097490
   Tesoriere L, 2008, J AGR FOOD CHEM, V56, P10487, DOI 10.1021/jf8017172
   Tesoriere L, 2013, BRIT J NUTR, V110, P230, DOI 10.1017/S000711451200493X
   Ting YW, 2014, J FUNCT FOODS, V7, P112, DOI 10.1016/j.jff.2013.12.010
   Tsai PJ, 2010, J AGR FOOD CHEM, V58, P1020, DOI 10.1021/jf9032766
   Vidal PJ, 2014, FOOD CHEM, V154, P246, DOI 10.1016/j.foodchem.2014.01.014
   Winkler C., 2005, American Journal of Biochemistry and Biotechnology, V1, P180
   Wroblewska M, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-178
   Wybraniec S, 2002, J AGR FOOD CHEM, V50, P6086, DOI 10.1021/jf020145k
   Wybraniec S, 2010, J CHROMATOGR B, V878, P538, DOI 10.1016/j.jchromb.2009.12.029
   Yahaghi L, 2020, PHYSIOL INT, V107, P67, DOI 10.1556/2060.2020.00001
   Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431
   Zhang YJ, 2015, MOLECULES, V20, P21138, DOI 10.3390/molecules201219753
   Zhao C, 2019, CRIT REV FOOD SCI, V59, P830, DOI 10.1080/10408398.2018.1501658
NR 99
TC 16
Z9 16
U1 2
U2 16
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1478-6419
EI 1478-6427
J9 NAT PROD RES
JI Nat. Prod. Res.
PD MAY 19
PY 2023
VL 37
IS 10
BP 1746
EP 1765
DI 10.1080/14786419.2022.2106481
EA JUL 2022
PG 20
WC Chemistry, Applied; Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA E3EQ2
UT WOS:000836054200001
PM 35921318
DA 2025-06-11
ER

PT J
AU Niederseer, D
   Wernly, B
   Aigner, E
   Stickel, F
   Datz, C
AF Niederseer, David
   Wernly, Bernhard
   Aigner, Elmar
   Stickel, Felix
   Datz, Christian
TI NAFLD and Cardiovascular Diseases: Epidemiological, Mechanistic and
   Therapeutic Considerations
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE diabetes; metabolic syndrome; lifestyle; atherosclerosis; NASH; liver;
   exercise; nutrition
ID NONALCOHOLIC FATTY LIVER; STEATOHEPATITIS
AB Overwhelming evidence suggests an association of cardiovascular disease (CVD) with non-alcoholic fatty liver disease (NAFLD); however, the underlying mechanisms remain largely speculative. It is, however, likely that common mechanisms contribute to the development of CVD and NAFLD, with lifestyle factors such as smoking, sedentary lifestyle with poor nutrition habits and physical inactivity being major candidates. These behavioral factors, on a predisposing genetic background, trigger changes in gut microbiota, inflammation, dyslipidemia and oxidative stress, leading to metabolic syndrome, diabetes and obesity as well as atherosclerosis. Treatment options to counteract both the progression and development of CVD and NAFLD include lifestyle interventions, optimal medical therapy of comorbid conditions and, as final possibility, bariatric surgery. As no causal pharmacotherapy of NAFLD is available, further research is urgently needed to address the unmet need of a growing population with NAFLD and CVD.
C1 [Niederseer, David] Univ Zurich, Univ Heart Ctr Zurich, Univ Hosp Zurich, Dept Cardiol, CH-8091 Zurich, Switzerland.
   [Wernly, Bernhard] Paracelsus Med Univ Salzburg, Dept Anaesthesiol Perioperat Med & Intens Care Me, A-5020 Salzburg, Austria.
   [Wernly, Bernhard] Paracelsus Med Univ Salzburg, Ctr Publ Hlth & Healthcare Res, A-5020 Salzburg, Austria.
   [Wernly, Bernhard] Paracelsus Med Univ Salzburg, Dept Cardiol, A-5020 Salzburg, Austria.
   [Aigner, Elmar] Paracelsus Med Univ, Dept Med 1, A-5020 Salzburg, Austria.
   [Stickel, Felix] Univ Zurich, Univ Hosp Zurich, Dept Gastroenterol, CH-8091 Zurich, Switzerland.
   [Datz, Christian] Paracelsus Med Univ, Teaching Hosp, Gen Hosp Oberndorf, Dept Internal Med, A-5110 Oberndorf, Austria.
C3 University of Zurich; University Zurich Hospital; Paracelsus Private
   Medical University; Paracelsus Private Medical University; Paracelsus
   Private Medical University; Paracelsus Private Medical University;
   University of Zurich; University Zurich Hospital; Paracelsus Private
   Medical University
RP Datz, C (corresponding author), Paracelsus Med Univ, Teaching Hosp, Gen Hosp Oberndorf, Dept Internal Med, A-5110 Oberndorf, Austria.
EM david.niederseer@usz.ch; bernhard@wernly.net; e.aigner@salk.at;
   felix.stickel@uzh.ch; c.datz@kh-oberndorf.at
RI Wernly, Bernhard/AAA-8529-2020; Niederseer, David/X-7363-2018
OI Niederseer, David/0000-0003-3089-1222; Datz,
   Christian/0000-0001-7838-4532; Wernly, Bernhard/0000-0003-4024-0220
FU SPAR Austria AG
FX C.D. was funded by SPAR Austria AG.
CR [Anonymous], 2019, DIABETES CARE, V42, pS4, DOI 10.2337/dc19-Srev01
   Arnett DK, 2019, CIRCULATION, V140, pE563, DOI [10.1016/j.jacc.2019.03.009, 10.1016/j.jacc.2019.03.010, 10.1161/CIR.0000000000000678, 10.1161/CIR.0000000000000677]
   Cosentino F, 2020, EUR HEART J, V41, P255, DOI 10.1093/eurheartj/ehz486
   EASL, 2016, OBESITY FACTS, V9, P65, DOI [10.1159/000443344, 10.1007/s00125-016-3902-y, 10.1016/j.jhep.2015.11.004]
   Pelliccia A, 2021, EUR HEART J, V42, P17, DOI [10.1093/eurheartj/ehaa605, 10.1093/eurheartj/ehaa835]
   Söderberg C, 2010, HEPATOLOGY, V51, P595, DOI 10.1002/hep.23314
   Stahl EP, 2019, J AM COLL CARDIOL, V73, P948, DOI 10.1016/j.jacc.2018.11.050
   Stepanova M, 2012, CLIN GASTROENTEROL H, V10, P646, DOI 10.1016/j.cgh.2011.12.039
   Stols-Gonçalves D, 2019, TRENDS ENDOCRIN MET, V30, P891, DOI 10.1016/j.tem.2019.08.008
   Tacelli M, 2018, PHARMACEUTICALS-BASE, V11, DOI 10.3390/ph11040121
   Tilg Herbert, 2020, Nat Rev Immunol, V20, P40, DOI 10.1038/s41577-019-0198-4
   Turnbaugh PJ, 2012, NATURE, V487, P47, DOI 10.1038/487047a
   Vasunta RL, 2012, J HYPERTENS, V30, P2015, DOI 10.1097/HJH.0b013e3283576faf
   Verrijken A, 2014, HEPATOLOGY, V59, P121, DOI 10.1002/hep.26510
   WANLESS IR, 1990, HEPATOLOGY, V12, P1106, DOI 10.1002/hep.1840120505
   Weisberg SP, 2006, J CLIN INVEST, V116, P115, DOI 10.1172/JCI24335
   Widjaja AA, 2019, GASTROENTEROLOGY, V157, P777, DOI 10.1053/j.gastro.2019.05.002
   Wójcik-Cichy K, 2018, CLIN EXP HEPATOL, V4, P1, DOI 10.5114/ceh.2018.73155
   Wong VWS, 2016, HEPATOLOGY, V63, P754, DOI 10.1002/hep.28253
   Wu SF, 2016, SCI REP-UK, V6, DOI 10.1038/srep25821
   Yan HM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0134172
   Yeung ENW, 2015, LIPIDS HEALTH DIS, V14, DOI 10.1186/s12944-015-0069-3
   Yki-Järvinen H, 2014, LANCET DIABETES ENDO, V2, P901, DOI 10.1016/S2213-8587(14)70032-4
   Young S, 2020, HEPATOL COMMUN, V4, P953, DOI 10.1002/hep4.1519
   Yu LX, 2017, NAT REV GASTRO HEPAT, V14, P527, DOI 10.1038/nrgastro.2017.72
   Zewinger S, 2020, NAT IMMUNOL, V21, P30, DOI 10.1038/s41590-019-0548-1
   Zhang L, 2020, CLIN SCI, V134, P1775, DOI 10.1042/CS20200446
   Zhang YW, 2019, BMC GENOMICS, V20, DOI 10.1186/s12864-019-6251-7
   Zhu LX, 2013, HEPATOLOGY, V57, P601, DOI 10.1002/hep.26093
   Zhu WF, 2016, CELL, V165, P111, DOI 10.1016/j.cell.2016.02.011
NR 30
TC 55
Z9 56
U1 1
U2 23
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD FEB
PY 2021
VL 10
IS 3
AR 467
DI 10.3390/jcm10030467
PG 23
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA QD2KS
UT WOS:000615354600001
PM 33530440
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gómez-Guzmán, M
   Rodríguez-Nogales, A
   Algieri, F
   Gálvez, J
AF Gomez-Guzman, Manuel
   Rodriguez-Nogales, Alba
   Algieri, Francesca
   Galvez, Julio
TI Potential Role of Seaweed Polyphenols in Cardiovascular-Associated
   Disorders
SO MARINE DRUGS
LA English
DT Review
DE cardiovascular diseases; hypertension; immune response; metabolic
   syndrome; seaweed polyphenols
ID ALLEVIATES POSTPRANDIAL HYPERGLYCEMIA; REDUCING OXIDATIVE STRESS;
   UNDARIA-PINNATIFIDA WAKAME; ECKLONIA-CAVA; ALPHA-GLUCOSIDASE; BROWN
   SEAWEED; IN-VITRO; ANTIOXIDANT ACTIVITIES; INHIBITORY-ACTIVITY;
   PHENOLIC-COMPOUNDS
AB The beneficial effects of various polyphenols with plant origins on different cardiovascular-associated disorders, such as hypertension, diabetes mellitus type 2 and metabolic syndrome are well known. Recently, marine crude-drugs are emerging as potential treatments in many noncommunicable conditions, including those involving the cardiovascular system. Among the active compounds responsible for these activities, seaweed polyphenols seem to play a key role. The aim of the present review is to summarise the current knowledge about the beneficial effects reported for edible seaweed polyphenols in the amelioration of these prevalent conditions, focusing on both preclinical and clinical studies. This review will help to establish the basis for future studies in this promising field.
C1 [Gomez-Guzman, Manuel] Univ Granada, Sch Pharm, Dept Pharmacol, E-18071 Granada, Spain.
   [Gomez-Guzman, Manuel; Rodriguez-Nogales, Alba; Algieri, Francesca; Galvez, Julio] Inst Invest Biosanitaria Granada Ibs Granada, Granada 18071, Spain.
   [Rodriguez-Nogales, Alba; Algieri, Francesca; Galvez, Julio] Univ Granada, CIBER EHD, Dept Pharmacol, Ctr Biomed Res CIBM, E-18071 Granada, Spain.
C3 University of Granada; Instituto de Investigacion Biosanitaria IBS
   Granada; CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD;
   University of Granada
RP Gálvez, J (corresponding author), Inst Invest Biosanitaria Granada Ibs Granada, Granada 18071, Spain.; Gálvez, J (corresponding author), Univ Granada, CIBER EHD, Dept Pharmacol, Ctr Biomed Res CIBM, E-18071 Granada, Spain.
EM mgguzman@ugr.es; albarnogales@gmail.com; fra.algieri@hotmail.it;
   jgalvez@ugr.es
RI Rodríguez-Nogales, Alba/J-2782-2017; Algieri, Francesca/J-4281-2017;
   Galvez, Julio/K-6875-2014; Gomez-Guzman, Manuel/E-3341-2012; Algieri,
   Francesca/L-3231-2014
OI Galvez, Julio/0000-0001-6876-3782; Gomez-Guzman,
   Manuel/0000-0003-2452-9286; Algieri, Francesca/0000-0002-0262-4867
FU Junta de Andalucia [CTS 164]; Spanish Ministry of Economy and
   Competitiveness [AGL2015-67995-C3-3-R]; European Union; Instituto de
   Salud Carlos III
FX This work was supported by the Junta de Andalucia (CTS 164) and by the
   Spanish Ministry of Economy and Competitiveness (AGL2015-67995-C3-3-R)
   with funds from the European Union. The CIBER-EHD is funded by the
   Instituto de Salud Carlos III.
CR AbouZid SF, 2014, J MED FOOD, V17, P400, DOI 10.1089/jmf.2013.0068
   Actis-Goretta L, 2006, J AGR FOOD CHEM, V54, P229, DOI 10.1021/jf052263o
   Admassu H, 2018, J FOOD SCI, V83, P6, DOI 10.1111/1750-3841.14011
   Afridi I, 2003, J HYPERTENS, V21, P1983, DOI 10.1097/01.hjh.0000084751-37215.d2
   Aggarwal M, 2017, MED CLIN N AM, V101, P895, DOI 10.1016/j.mcna.2017.04.007
   Ahmed N, 2005, DIABETES RES CLIN PR, V67, P3, DOI 10.1016/j.diabres.2004.09.004
   Akter S, 2015, HYPERTENS RES, V38, P208, DOI 10.1038/hr.2014.160
   Al Disi SS, 2016, FRONT PHARMACOL, V6, DOI 10.3389/fphar.2015.00323
   Alwan A, 2010, GLOBAL STATUS REPORT
   Athiperumalsami T, 2010, BOT MAR, V53, P251, DOI 10.1515/BOT.2010.032
   Audibert L, 2010, PHYTOCHEM ANALYSIS, V21, P399, DOI 10.1002/pca.1210
   Beaulieu L, 2016, J APPL PHYCOL, V28, P3101, DOI 10.1007/s10811-016-0850-3
   BECKER EW, 1986, NUTR REP INT, V33, P565
   Cardoso SM, 2015, MAR DRUGS, V13, P6838, DOI 10.3390/md13116838
   Cha Seon-Heui, 2006, Algae, V21, P343
   CHA SH, 2018, OXID MED CELL LONGEV, V2018, DOI [10.1155/2018/3654095, DOI 10.1155/2018/3654095]
   Chen YY, 2010, BIOMED PHARMACOTHER, V64, P291, DOI 10.1016/j.biopha.2009.09.004
   Choi HS, 2015, MOL NUTR FOOD RES, V59, P1458, DOI 10.1002/mnfr.201500021
   Cian RE, 2014, INT J FOOD SCI NUTR, V65, P299, DOI 10.3109/09637486.2013.854746
   Cian RE, 2012, FOOD CHEM, V134, P1982, DOI 10.1016/j.foodchem.2012.03.134
   Cicero AFG, 2016, PHYTOMEDICINE, V23, P1134, DOI 10.1016/j.phymed.2015.11.009
   Corona G, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201700223
   Dawczynski C, 2007, J AGR FOOD CHEM, V55, P10470, DOI 10.1021/jf0721500
   Deka A, 2011, PHARMACOL RES, V64, P136, DOI 10.1016/j.phrs.2011.03.009
   Engin AB, 2018, FOOD CHEM TOXICOL, V112, P157, DOI 10.1016/j.fct.2017.12.055
   Eo H, 2015, J AGR FOOD CHEM, V63, P349, DOI 10.1021/jf502830b
   Eom SH, 2012, FOOD CHEM TOXICOL, V50, P3251, DOI 10.1016/j.fct.2012.06.028
   Estruch R, 2018, NEW ENGL J MED, V378, DOI [10.1056/NEJMoa1800389, 10.1056/NEJMoa1200303, 10.1056/nejmoa1800389]
   Faggio C, 2017, EUR J PHARMACOL, V807, P91, DOI 10.1016/j.ejphar.2017.04.009
   Farvin KHS, 2013, FOOD CHEM, V138, P1670, DOI 10.1016/j.foodchem.2012.10.078
   Fernández-Segovia I, 2018, FOOD RES INT, V111, P212, DOI 10.1016/j.foodres.2018.05.037
   Fernando IPS, 2016, J MED FOOD, V19, P615, DOI 10.1089/jmf.2016.3706
   Fitzgerald C, 2012, J AGR FOOD CHEM, V60, P7421, DOI 10.1021/jf301361c
   Galiè N, 2008, LANCET, V371, P2093, DOI 10.1016/S0140-6736(08)60919-8
   García-Casal MN, 2009, BRIT J NUTR, V101, P79, DOI 10.1017/S0007114508994757
   Gargouri M, 2018, APPL PHYSIOL NUTR ME, V43, P345, DOI 10.1139/apnm-2017-0461
   Gargouri M, 2016, NUTR RES, V36, P1255, DOI 10.1016/j.nutres.2016.09.011
   Grundy SM, 2012, J AM COLL CARDIOL, V59, P635, DOI 10.1016/j.jacc.2011.08.080
   Harnedy PA, 2013, CURR PROTEIN PEPT SC, V14, P162
   Hata Y, 2001, J CLIN BIOCHEM NUTR, V30, P43
   Heo SJ, 2005, BIORESOURCE TECHNOL, V96, P1613, DOI 10.1016/j.biortech.2004.07.013
   Heo SJ, 2009, EUR J PHARMACOL, V615, P252, DOI 10.1016/j.ejphar.2009.05.017
   Herder C, 2015, TRENDS ENDOCRIN MET, V26, P551, DOI 10.1016/j.tem.2015.08.001
   Hermund DB, 2018, FOOD CHEM, V240, P904, DOI 10.1016/j.foodchem.2017.08.032
   Hooper L, 2012, AM J CLIN NUTR, V95, P740, DOI 10.3945/ajcn.111.023457
   Hügel HM, 2016, PHYTOMEDICINE, V23, P220, DOI 10.1016/j.phymed.2015.12.012
   Hwang PA, 2015, CYTOTECHNOLOGY, V67, P653, DOI 10.1007/s10616-014-9745-9
   Indra Mochamad Rasjad, 2013, BMC Res Notes, V6, P275, DOI 10.1186/1756-0500-6-275
   Jarouliya U, 2012, INDIAN J MED RES, V135, P422
   Jeon You-Jin, 2005, Preventive Nutrition and Food Science, V10, P134
   Jiménez R, 2012, J AGR FOOD CHEM, V60, P8823, DOI 10.1021/jf205370q
   Jung HA, 2006, FISHERIES SCI, V72, P1292, DOI 10.1111/j.1444-2906.2006.01288.x
   Kadam PD, 2016, INT UROGYNECOL J, V27, P505, DOI 10.1007/s00192-016-2952-5
   Kaiser N, 2003, J PEDIATR ENDOCR MET, V16, P5, DOI 10.1515/JPEM.2003.16.1.5
   Kang C, 2010, FOOD CHEM TOXICOL, V48, P509, DOI 10.1016/j.fct.2009.11.004
   Kang MC, 2013, FOOD CHEM TOXICOL, V53, P294, DOI 10.1016/j.fct.2012.12.012
   Kellogg J, 2015, J FUNCT FOODS, V15, P396, DOI 10.1016/j.jff.2015.03.049
   Kim EA, 2016, RSC ADV, V6, P78570, DOI 10.1039/c6ra12724j
   Koivikko R, 2005, J CHEM ECOL, V31, P195, DOI 10.1007/s10886-005-0984-2
   Krishan S, 2015, MOL PHARMACOL, V87, P363, DOI 10.1124/mol.114.095810
   KROTKIEWSKI M, 1991, AM J HYPERTENS, V4, P483, DOI 10.1093/ajh/4.6.483
   Kuda T, 2005, J FOOD COMPOS ANAL, V18, P625, DOI 10.1016/j.jfca.2004.06.015
   Laurent S, 2017, PHARMACOL RES, V124, P116, DOI 10.1016/j.phrs.2017.07.026
   Lee HA, 2018, BIOMED PHARMACOTHER, V103, P1473, DOI 10.1016/j.biopha.2018.04.129
   Lee HA, 2017, PHARM BIOL, V55, P1149, DOI 10.1080/13880209.2017.1291693
   Lee SH, 2016, FOOD CHEM TOXICOL, V91, P58, DOI 10.1016/j.fct.2016.02.022
   Lee SH, 2015, FOOD FUNCT, V6, P853, DOI 10.1039/c4fo00940a
   Lee SH, 2014, FOOD FUNCT, V5, P2602, DOI 10.1039/c4fo00420e
   Lee SH, 2013, FOOD CHEM TOXICOL, V59, P643, DOI 10.1016/j.fct.2013.07.011
   Lee SH, 2012, BIOSCI BIOTECH BIOCH, V76, P1445, DOI 10.1271/bbb.120096
   Lee SH, 2012, FOOD CHEM TOXICOL, V50, P575, DOI 10.1016/j.fct.2011.12.032
   Lee SH, 2010, FOOD CHEM TOXICOL, V48, P2633, DOI 10.1016/j.fct.2010.06.032
   Leitner DR, 2017, OBESITY FACTS, V10, P483, DOI 10.1159/000480525
   Li LJ, 2015, DRUG DISCOV TODAY, V20, P1074, DOI 10.1016/j.drudis.2015.04.009
   Li Y, 2009, BIOORGAN MED CHEM, V17, P1963, DOI 10.1016/j.bmc.2009.01.031
   Li YX, 2011, PROCESS BIOCHEM, V46, P2219, DOI 10.1016/j.procbio.2011.09.015
   Liu BR, 2016, FOOD CHEM, V203, P16, DOI 10.1016/j.foodchem.2016.02.001
   Liu JC, 2003, LIFE SCI, V73, P1543, DOI 10.1016/S0024-3205(03)00481-8
   Liu M, 2011, MAR DRUGS, V9, P1273, DOI 10.3390/md9071273
   Lopes G, 2017, MOLECULES, V22, DOI 10.3390/molecules22010056
   Min KH, 2011, DIABETES RES CLIN PR, V93, P70, DOI 10.1016/j.diabres.2011.03.018
   Moon HE, 2011, BIOSCI BIOTECH BIOCH, V75, P1472, DOI 10.1271/bbb.110137
   Muka T, 2015, EUR J EPIDEMIOL, V30, P251, DOI 10.1007/s10654-014-9984-2
   Murray M., 2017, CRIT REV FOOD SCI NU, V26, P1
   Murray M, 2018, NUTRIENTS, V10, DOI 10.3390/nu10030270
   Nakai M, 2006, MAR BIOTECHNOL, V8, P409, DOI 10.1007/s10126-005-6168-9
   Namvar F, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/604787
   Noguchi N, 2013, OBES RES CLIN PRACT, V7, pE95, DOI 10.1016/j.orcp.2013.01.002
   Nwosu F, 2011, FOOD CHEM, V126, P1006, DOI 10.1016/j.foodchem.2010.11.111
   Paiva L, 2016, J PHARMACEUT BIOMED, V131, P503, DOI 10.1016/j.jpba.2016.08.029
   Panzhinskiy E, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0077228
   Paradis ME, 2011, APPL PHYSIOL NUTR ME, V36, P913, DOI [10.1139/h11-115, 10.1139/H11-115]
   Park BG, 2008, BIOORG MED CHEM LETT, V18, P6324, DOI 10.1016/j.bmcl.2008.10.103
   Park BG, 2017, BIOORGAN MED CHEM, V25, P4649, DOI 10.1016/j.bmc.2017.07.002
   Park EY, 2015, MAR DRUGS, V13, P6866, DOI 10.3390/md13116866
   Park MH, 2015, FITOTERAPIA, V106, P135, DOI 10.1016/j.fitote.2015.08.014
   Park SR, 2018, FOOD CHEM, V257, P128, DOI 10.1016/j.foodchem.2018.03.013
   Perez-Vizcaino F, 2010, MOL ASPECTS MED, V31, P478, DOI 10.1016/j.mam.2010.09.002
   Perez-Vizcaino F, 2009, PHARMACOL REP, V61, P67, DOI 10.1016/S1734-1140(09)70008-8
   Pintérová M, 2011, PHYSIOL RES, V60, P381, DOI 10.33549/physiolres.932189
   Qu WJ, 2015, PROCESS BIOCHEM, V50, P245, DOI 10.1016/j.procbio.2014.11.010
   Qu WJ, 2010, FOOD CHEM, V123, P14, DOI 10.1016/j.foodchem.2010.03.091
   Rajauria G, 2018, J PHARMACEUT BIOMED, V148, P230, DOI 10.1016/j.jpba.2017.10.002
   Rochette L, 2014, BBA-GEN SUBJECTS, V1840, P2709, DOI 10.1016/j.bbagen.2014.05.017
   Romero M, 2009, ATHEROSCLEROSIS, V202, P58, DOI 10.1016/j.atherosclerosis.2008.03.007
   Roy MC, 2011, FOOD RES INT, V44, P3026, DOI 10.1016/j.foodres.2011.07.023
   Sanchez M., 2018, CURR MED CHEM
   Sanchez M, 2007, J NUTR, V137, P910, DOI 10.1093/jn/137.4.910
   Sato M, 2002, J AGR FOOD CHEM, V50, P6245, DOI 10.1021/jf020482t
   Shi DY, 2008, CHINESE SCI BULL, V53, P2476, DOI 10.1007/s11434-008-0353-y
   Shibata T, 2008, J APPL PHYCOL, V20, P705, DOI 10.1007/s10811-007-9254-8
   Shin WS, 2013, VASC PHARMACOL, V58, P299, DOI 10.1016/j.vph.2013.02.001
   Sivagnanam SP, 2015, MAR DRUGS, V13, P3422, DOI 10.3390/md13063422
   Spiegelman BM, 2001, CELL, V104, P531, DOI 10.1016/S0092-8674(01)00240-9
   Suetsuna K, 2000, J NUTR BIOCHEM, V11, P450, DOI 10.1016/S0955-2863(00)00110-8
   Suetsuna K, 2004, J NUTR BIOCHEM, V15, P267, DOI 10.1016/j.jnutbio.2003.11.004
   Tabassum Nahida, 2011, Pharmacogn Rev, V5, P30, DOI 10.4103/0973-7847.79097
   Terakado S, 2012, CLIN EXP HYPERTENS, V34, P99, DOI 10.3109/10641963.2011.618196
   Tibbetts SM, 2016, J APPL PHYCOL, V28, P3575, DOI 10.1007/s10811-016-0863-y
   Tierney MS, 2013, FOOD CHEM, V139, P753, DOI 10.1016/j.foodchem.2013.01.019
   Tomé-Carneiro J, 2013, ANN NY ACAD SCI, V1290, P37, DOI 10.1111/nyas.12150
   Valdés L, 2015, FOOD FUNCT, V6, P2424, DOI [10.1039/c5fo00322a, 10.1039/C5FO00322A]
   Wada K, 2011, NUTR J, V10, DOI 10.1186/1475-2891-10-83
   Wang T, 2009, FOOD CHEM, V116, P240, DOI 10.1016/j.foodchem.2009.02.041
   Wang YJ, 2017, MAR DRUGS, V15, DOI 10.3390/md15010018
   Weber MA, 2009, LANCET, V374, P1423, DOI 10.1016/S0140-6736(09)61500-2
   Wells ML, 2017, J APPL PHYCOL, V29, P949, DOI 10.1007/s10811-016-0974-5
   Wijesekara I, 2010, MAR DRUGS, V8, P1080, DOI 10.3390/md8041080
   Wijesinghe WAJP, 2011, NUTR RES PRACT, V5, P93, DOI 10.4162/nrp.2011.5.2.93
   Yoon JY, 2017, MAR DRUGS, V15, DOI 10.3390/md15040106
   You HN, 2015, EUR J PHARMACOL, V752, P92, DOI 10.1016/j.ejphar.2015.02.003
   Zhang JZ, 2007, CAN J PHYSIOL PHARM, V85, P1116, DOI 10.1139/Y07-105
   Zhang Lijuan, 2016, Zhongguo Zhen Jiu, V36, P131
NR 133
TC 109
Z9 114
U1 2
U2 38
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-3397
J9 MAR DRUGS
JI Mar. Drugs
PD AUG
PY 2018
VL 16
IS 8
AR 250
DI 10.3390/md16080250
PG 21
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HI8WP
UT WOS:000456736900003
PM 30060542
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Vágvölgyi, A
   Abrahám, JE
   Köteles, EM
   Korom, A
   Barnai, M
   Szücs, M
   Orosz, A
   Kempler, P
   Menyhart, A
   Nemes, A
   Várkonyi, T
   Baczko, I
   Kósa, I
   Lengyel, C
AF Vagvolgyi, Anna
   Abraham, Judit Erzsebet
   Koteles, Eva Mathene
   Korom, Andrea
   Barnai, Maria
   Szucs, Monika
   Orosz, Andrea
   Kempler, Peter
   Menyhart, Adrienn
   Nemes, Attila
   Varkonyi, Tamas
   Baczko, Istvan
   Kosa, Istvan
   Lengyel, Csaba
TI A three-month physical training program improves cardiovascular
   autonomic function in patients with metabolic syndrome with and without
   diabetes - a pilot study
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE autonomic function; cardiovascular; diabetes; metabolic syndrome;
   physical exercise
ID MULTIFACTORIAL INTERVENTION; OBESITY EPIDEMIC; UNITED-STATES;
   NEUROPATHY; DIAGNOSIS; DISEASE; GLUCOSE; IMPACT; RISK; DYSFUNCTION
AB Introduction: Vascular complications and neuropathy may develop in the presence of metabolic syndrome. The aim of our study was to measure the cardiovascular autonomic function following physical training in patients with metabolic syndrome with and without diabetes.
   Subjects and methods: 56 patients with metabolic syndrome (32 men/24 women, 40 non-diabetic patients (NDMetS)/16 diabetic patients (DMetS) [mean +/- SD]: age: 50.35 +/- 8.03 vs. 56.8 +/- 9.30 years, p=0.023; baseline BMI: 32.2 +/- 7.03 vs. 32.8 +/- 5.94 kg/m2, p=0.739) were involved in our study. All tests and measurements were carried out before and following a 3-month physical training period. Autonomic function was assessed by means of five standard cardiovascular reflex tests. ECG repolarization parameters, including short-term QT variability and stress-ECG were also measured.
   Results: In the whole population, Valsalva-ratio (VR) and the autonomic score (AS) improved following training (VR: 1.49 +/- 0.24 vs. 1.64 +/- 0.34, p=0.001; AS: 2.05 +/- 1.73 vs. 1.41 +/- 1.36, p=0.015) accompanied by the significant decrease of the systolic (150.3 +/- 16.12 vs. 134.1 +/- 16.67 mmHg, p<0.001) and diastolic (90.64 +/- 12.8 vs. 82.79 +/- 11.1 mmHg, p<0.001) blood pressure. An improvement in VR was detected in NDMetS patients following training (1.51 +/- 0.24 vs. 1.67 +/- 0.31, p= 0.002). No significant changes could be detected in autonomic tests' results in the DMetS patient group following training. The applied exercise training program did not lead to significant changes in ECG repolarization. The stress-ECG test in the whole study population yielded a significant increase in the test duration (12.9 +/- 3.76 vs. 15.1 +/- 2.96 min, p<0.001) and in the test load (10.5 +/- 2.78 vs. 11.6 +/- 2.39 MET, p<0.001). The load capability improved significantly in both subgroups: 11.1 +/- 2.04 vs. 12.1 +/- 1.82, (p<0.001) and 9.0 +/- 3.64 vs. 10.4 +/- 3.05, (p=0.033) in subpopulations of NDMetS and DMetS, respectively. The DMetS patients achieved a significantly lower MET score at baseline (p=0.039) and following training (p=0.044) in comparison to the NDMetS patients.
   Conclusion: The three-month exercise program improved the Valsalva-ratio and the AN score in the MetS patients, that is potentially protective against cardiovascular events. The training had some beneficial effect on blood pressure and the results of the stress-ECG tests in both groups. The absence of significant change in the reflex tests in DMetS group reflects an impaired adaptation compared to the NDMestS group.
C1 [Vagvolgyi, Anna; Nemes, Attila; Varkonyi, Tamas; Kosa, Istvan; Lengyel, Csaba] Univ Szeged, Albert Szent Gyorgy Med Sch, Dept Med, Szeged, Hungary.
   [Abraham, Judit Erzsebet; Kosa, Istvan] Univ Szeged, Albert Szent Gyorgy Med Sch, Dept Med Prevent, Szeged, Hungary.
   [Koteles, Eva Mathene; Korom, Andrea; Barnai, Maria] Univ Szeged, Fac Hlth Sci & Social Studies, Dept Physiotherapy, Szeged, Hungary.
   [Szucs, Monika] Univ Szeged, Albert Szent Gyorgy Med Sch, Dept Med Phys & Informat, Szeged, Hungary.
   [Orosz, Andrea; Baczko, Istvan] Univ Szeged, Albert Szent Gyorgy Med Sch, Dept Pharmacol & Pharmacotherapy, Szeged, Hungary.
   [Kempler, Peter; Menyhart, Adrienn] Semmelweis Univ, Dept Oncol & Internal Med, Budapest, Hungary.
C3 Szeged University; Szeged University; Szeged University; Szeged
   University; Szeged University; Semmelweis University
RP Nemes, A (corresponding author), Univ Szeged, Albert Szent Gyorgy Med Sch, Dept Med, Szeged, Hungary.
EM attila.nemes.md@gmail.com
RI Szucs, Monika/I-5292-2018; Baczko, István/I-7752-2019; Kósa,
   István/AHE-4081-2022
OI Szucs, Monika/0000-0002-8791-9452; Mathene Koteles,
   Eva/0000-0002-9728-5182; Baczko, Istvan/0000-0002-9588-0797
FU Supported by the Hungarian Diabetes Association, and the European Union,
   co-financed by the European Social Fund (EFOP-3.6.1-16-2016-00008 and
   EFOP-3.6.3-VEKOP-16-2017-00009) and by Project no.
   RRF-2.3.1-21-2022-00003 that has been implemented with the sup;
   Hungarian Diabetes Association [EFOP-3.6.3-VEKOP-16-2017-00009,
   RRF-2.3.1-21-2022-00003]; European Union - European Social Fund;
   European Union;  [EFOP-3.6.1-16-2016-00008]
FX Supported by the Hungarian Diabetes Association, and the European Union,
   co-financed by the European Social Fund (EFOP-3.6.1-16-2016-00008 and
   EFOP-3.6.3-VEKOP-16-2017-00009) and by Project no.
   RRF-2.3.1-21-2022-00003 that has been implemented with the support
   provided by the European Union.r Supported by the Hungarian Diabetes
   Association, and the European Union, co-financed by the European Social
   Fund (EFOP-3.6.1-16-2016-00008 and EFOP-3.6.3-VEKOP-16-2017-00009) and
   by Project no. RRF-2.3.1-21-2022-00003 that has been implemented with
   the support provided by the European Union.
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Arnett DK, 2019, CIRCULATION, V140, pE563, DOI [10.1016/j.jacc.2019.03.009, 10.1016/j.jacc.2019.03.010, 10.1161/CIR.0000000000000678, 10.1161/CIR.0000000000000677]
   Baum P, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054546
   Baumert M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041920
   Brennan M, 2001, IEEE T BIO-MED ENG, V48, P1342, DOI 10.1109/10.959330
   Brown DW, 2001, J CARDIOVASC RISK, V8, P227, DOI 10.1097/00043798-200108000-00007
   Bull Fiona C, 2020, Br J Sports Med, V54, P1451, DOI 10.1136/bjsports-2020-102955
   Church TS, 2009, DIABETES CARE, V32, P1289, DOI 10.2337/dc08-1871
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   EWING DJ, 1991, DIABETOLOGIA, V34, P182, DOI 10.1007/BF00418273
   EWING DJ, 1982, BRIT MED J, V285, P916, DOI 10.1136/bmj.285.6346.916
   EWING DJ, 1985, DIABETES CARE, V8, P491, DOI 10.2337/diacare.8.5.491
   Fisher VL, 2017, DIABET METAB SYND OB, V10, P419, DOI 10.2147/DMSO.S129797
   Franco OH, 2009, CIRCULATION, V120, P1943, DOI 10.1161/CIRCULATIONAHA.109.855817
   Gaede P, 2003, NEW ENGL J MED, V348, P383, DOI 10.1056/NEJMoa021778
   Gaede P, 2008, NEW ENGL J MED, V358, P580, DOI 10.1056/NEJMoa0706245
   GRASSI G, 1979, HYPERTENS DALLAS TEX, V2009, P690, DOI DOI 10.1161/HYPERTENSIONAHA.108.119883
   Grassi G, 2015, CIRC RES, V116, P976, DOI 10.1161/CIRCRESAHA.116.303604
   Gregg EW, 2013, POPUL HEALTH METR, V11, DOI 10.1186/1478-7954-11-18
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Jakubiak GK, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11010079
   Kluding PM, 2012, J DIABETES COMPLICAT, V26, P424, DOI 10.1016/j.jdiacomp.2012.05.007
   Köteles ÉM, 2023, FRONT CARDIOVASC MED, V9, DOI 10.3389/fcvm.2022.1075361
   Laitinen T, 2011, DIABETIC MED, V28, P699, DOI 10.1111/j.1464-5491.2011.03278.x
   Manolis AJ, 2014, CURR VASC PHARMACOL, V12, P4
   Maser RE, 2007, CURR DIABETES REV, V3, P204, DOI 10.2174/157339907781368931
   Michou V, 2023, LIFE-BASEL, V13, DOI 10.3390/life13010232
   Mokdad AH, 1999, JAMA-J AM MED ASSOC, V282, P1519, DOI 10.1001/jama.282.16.1519
   Pagkalos M, 2008, BRIT J SPORT MED, V42, DOI 10.1136/bjsm.2007.035303
   Pop-Busui R, 2017, DIABETES CARE, V40, P136, DOI 10.2337/dc16-2042
   Popkin BM, 1998, NUTR REV, V56, P106
   Scuteri A, 2015, EUR J PREV CARDIOL, V22, P486, DOI 10.1177/2047487314525529
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Spallone V, 2019, DIABETES METAB J, V43, P3
   Spallone V, 2011, DIABETES-METAB RES, V27, P639, DOI 10.1002/dmrr.1239
   Stuckey Melanie I, 2013, Front Endocrinol (Lausanne), V4, P121, DOI 10.3389/fendo.2013.00121
   Tesfaye S, 2010, DIABETES CARE, V33, P2285, DOI 10.2337/dc10-1303
   Valensi P, 2021, CARDIOVASC DIABETOL, V20, DOI 10.1186/s12933-021-01356-w
   Vinik AI, 2007, CIRCULATION, V115, P387, DOI 10.1161/CIRCULATIONAHA.106.634949
   Vinik AI, 2018, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00591
   Vinik AI, 2003, DIABETES CARE, V26, P1553, DOI 10.2337/diacare.26.5.1553
   Visseren FLJ, 2022, EUR J PREV CARDIOL, V29, P5, DOI [10.1093/eurjpc/zwab154, 10.1093/eurheartj/ehac458, 10.1093/eurheartj/ehab484]
   Williams S, 2022, CLIN THER, V44, P1394, DOI 10.1016/j.clinthera.2022.09.002
   Williams SM, 2019, DIABETES THER, V10, P1995, DOI 10.1007/s13300-019-00693-0
   Yadav RL, 2017, DIABET METAB SYND OB, V10, P57, DOI 10.2147/DMSO.S123935
   Ziegler D, 2015, DIABETOLOGIA, V58, P1118, DOI 10.1007/s00125-015-3534-7
NR 46
TC 4
Z9 4
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD AUG 17
PY 2023
VL 14
AR 1224353
DI 10.3389/fendo.2023.1224353
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA Q6XS2
UT WOS:001058940200001
PM 37664832
OA gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Mitchell, T
   Chacko, B
   Ballinger, SW
   Bailey, SM
   Zhang, JH
   Darley-Usmar, V
AF Mitchell, Tanecia
   Chacko, Balu
   Ballinger, Scott W.
   Bailey, Shannon M.
   Zhang, Jianhua
   Darley-Usmar, Victor
TI Convergent mechanisms for dysregulation of mitochondrial quality control
   in metabolic disease: implications for mitochondrial therapeutics
SO BIOCHEMICAL SOCIETY TRANSACTIONS
LA English
DT Article
DE alcoholic liver disease; cellular bioenergetics; diabetes; metabolic
   syndrome; mitochondria; mitoquinone (MitoQ); reserve respiratory
   capacity; steatosis
ID ANTIOXIDANT MITOQ PROTECTS; ALCOHOLIC LIVER-DISEASE; REACTIVE OXYGEN;
   HEPATOCELLULAR-CARCINOMA; SIGNAL-TRANSDUCTION; OXIDATIVE STRESS;
   NITRIC-OXIDE; RISK-FACTORS; ETHANOL; DYSFUNCTION
AB Mitochondrial dysfunction is associated with a broad range of pathologies including diabetes, ethanol toxicity, metabolic syndrome and cardiac failure. It is now becoming clear that maintaining mitochondrial quality through a balance between biogenesis, reserve capacity and mitophagy is critical in determining the response to metabolic or xenobiotic stress. In diseases associated with metabolic stress, such as Type II diabetes and non-alcoholic and alcoholic steatosis, the mitochondria are subjected to multiple 'hits' such as hypoxia and oxidative and nitrative stress, which can overwhelm the mitochondrial quality control pathways. In addition, the underlying mitochondrial genetics that evolved to accommodate high-energy demand, low-calorie supply environments may now be maladapted to modern lifestyles (low-energy demand, high-calorie environments). The pro-oxidant and pro-inflammatory environment of a sedentary western lifestyle has been associated with modified redox cell signalling pathways such as steatosis, hypoxic signalling, inflammation and fibrosis. These data suggest that loss of mitochondrial quality control is intimately associated with the aberrant activation of redox cell signalling pathways under pathological conditions. In the present short review, we discuss evidence from alcoholic liver disease supporting this concept, the insights obtained from experimental models and the application of bioenergetic-based therapeutics in the context of maintaining mitochondrial quality.
C1 [Mitchell, Tanecia; Chacko, Balu; Ballinger, Scott W.; Bailey, Shannon M.; Zhang, Jianhua; Darley-Usmar, Victor] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA.
   [Mitchell, Tanecia; Chacko, Balu; Ballinger, Scott W.; Bailey, Shannon M.; Zhang, Jianhua; Darley-Usmar, Victor] Univ Alabama Birmingham, Ctr Free Radical Biol, Birmingham, AL 35294 USA.
   [Zhang, Jianhua] Univ Alabama Birmingham, Birmingham VA Med Ctr, Birmingham, AL 35294 USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Veterans Affairs Medical Center - Birmingham; University of Alabama
   System; University of Alabama Birmingham
RP Darley-Usmar, V (corresponding author), Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA.
EM darley@uab.edu
RI zhang, jianhua/D-3404-2009; Darley-Usmar, Victor/F-7656-2010
OI Zhang, Jianhua/0000-0002-2128-9574; Bailey, Shannon/0000-0003-0002-3424;
   Darley-Usmar, Victor/0000-0001-8921-7086
FU National Institutes of Health [T32 DK007545, HL 94518, HL 103859,
   DK073775, AA015172, AA018841, NS064090, AA13395]; VA merit award
FX This work was supported by National Institutes of Health [grant numbers
   T32 DK007545 (to T. M.), HL 94518 and HL 103859 (to S. B.), DK073775,
   AA015172 and AA018841 (to S. B.), NS064090 (to J.Z.), and AA13395 (to
   V.D.-U.)]. J.Z. was supported, in part, by a VA merit award.
CR Aitken R John, 2003, Reprod Biomed Online, V7, P65
   Albano E, 2008, MOL ASPECTS MED, V29, P9, DOI 10.1016/j.mam.2007.09.004
   Altamirano J, 2011, NAT REV GASTRO HEPAT, V8, P491, DOI 10.1038/nrgastro.2011.134
   Andringa KK, 2010, AM J PHYSIOL-GASTR L, V298, pG732, DOI 10.1152/ajpgi.00332.2009
   Bailey SM, 2006, AM J PHYSIOL-GASTR L, V291, pG857, DOI 10.1152/ajpgi.00044.2006
   Bailey SM, 2003, FREE RADICAL RES, V37, P585, DOI 10.1080/1071576031000091711
   Ballinger SW, 2002, CIRCULATION, V106, P544, DOI 10.1161/01.CIR.0000023921.93743.89
   Bellentani S, 1997, GUT, V41, P845, DOI 10.1136/gut.41.6.845
   Brookes PS, 2002, FREE RADICAL BIO MED, V33, P755, DOI 10.1016/S0891-5849(02)00901-2
   Butow RA, 2004, MOL CELL, V14, P1, DOI 10.1016/S1097-2765(04)00179-0
   Cassetti T, 2008, BMC CANCER, V8, DOI 10.1186/1471-2407-8-344
   Chacko BK, 2011, HEPATOLOGY, V54, P153, DOI 10.1002/hep.24377
   Chonghaile TN, 2011, SCIENCE, V334, P1129, DOI 10.1126/science.1206727
   Chuang GC, 2009, AM J PHYSIOL-LUNG C, V297, pL209, DOI 10.1152/ajplung.00102.2009
   Corrao G, 1997, INT J EPIDEMIOL, V26, P100, DOI 10.1093/ije/26.1.100
   Das S, 2012, PFLUG ARCH EUR J PHY, V464, P101, DOI 10.1007/s00424-012-1100-4
   Day CP, 2006, LIVER INT, V26, P1021, DOI 10.1111/j.1478-3231.2006.01323.x
   Donohue TM, 2009, WORLD J GASTROENTERO, V15, P1178, DOI 10.3748/wjg.15.1178
   DONOHUE TM, 1989, ALCOHOL CLIN EXP RES, V13, P49, DOI 10.1111/j.1530-0277.1989.tb00283.x
   Eccleston HB, 2011, ANTIOXID REDOX SIGN, V15, P447, DOI 10.1089/ars.2010.3395
   Gane EJ, 2010, LIVER INT, V30, P1019, DOI 10.1111/j.1478-3231.2010.02250.x
   Gomaa AI, 2008, WORLD J GASTROENTERO, V14, P4300, DOI 10.3748/wjg.14.4300
   Gómez-Durán A, 2010, HUM MOL GENET, V19, P3343, DOI 10.1093/hmg/ddq246
   Graham D, 2009, HYPERTENSION, V54, P322, DOI 10.1161/HYPERTENSIONAHA.109.130351
   Gutierrez J, 2006, CIRC RES, V99, P924, DOI 10.1161/01.RES.0000248212.86638.e9
   Ji C, 2008, J GASTROEN HEPATOL, V23, pS16, DOI 10.1111/j.1440-1746.2007.05276.x
   Kharbanda KK, 2012, INT J HEPATOL, V2012, DOI 10.1155/2012/962183
   Kim I, 2007, ARCH BIOCHEM BIOPHYS, V462, P245, DOI 10.1016/j.abb.2007.03.034
   Kim JS, 2008, HEPATOLOGY, V47, P1725, DOI 10.1002/hep.22187
   Kimura Y, 2005, HEPATOLOGY, V41, P55, DOI 10.1002/hep.20516
   Lee J, 2012, BIOCHEM J, V441, P523, DOI 10.1042/BJ20111451
   Lemasters JJ, 1998, BBA-BIOENERGETICS, V1366, P177, DOI 10.1016/S0005-2728(98)00112-1
   Lowes DA, 2009, FREE RADICAL RES, V43, P323, DOI 10.1080/10715760902736275
   Lowes DA, 2008, FREE RADICAL BIO MED, V45, P1559, DOI 10.1016/j.freeradbiomed.2008.09.003
   Lu MY, 2012, TRANSL RES, V159, P58, DOI 10.1016/j.trsl.2011.10.011
   Mantena SK, 2007, WORLD J GASTROENTERO, V13, P4967, DOI 10.3748/wjg.v13.i37.4967
   Marrero JA, 2005, J HEPATOL, V42, P218, DOI 10.1016/j.jhep.2004.10.005
   Murphy MP, 2009, BIOCHEM J, V417, P1, DOI 10.1042/BJ20081386
   Novak I, 2012, ANTIOXID REDOX SIGN, V17, P794, DOI 10.1089/ars.2011.4407
   Okamoto K, 2012, BBA-GEN SUBJECTS, V1820, P595, DOI 10.1016/j.bbagen.2011.08.001
   Onishi M, 2007, BIOCHEM BIOPH RES CO, V362, P183, DOI 10.1016/j.bbrc.2007.07.175
   Osna NA, 2007, WORLD J GASTROENTERO, V13, P4931, DOI 10.3748/wjg.v13.i37.4931
   Petta S, 2009, DIGEST LIVER DIS, V41, P615, DOI 10.1016/j.dld.2009.01.004
   Pezzotti A, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005356
   POSO AR, 1991, BIOCHEM J, V273, P149, DOI 10.1042/bj2730149
   Rautou PE, 2010, J HEPATOL, V53, P1123, DOI 10.1016/j.jhep.2010.07.006
   Seth D, 2011, J GASTROEN HEPATOL, V26, P1089, DOI 10.1111/j.1440-1746.2011.06756.x
   Shiva S, 2005, FREE RADICAL BIO MED, V38, P297, DOI 10.1016/j.freeradbiomed.2004.10.037
   Shukla SD, 2006, WORLD J GASTROENTERO, V12, P5265, DOI 10.3748/wjg.v12.i33.5265
   Smith RAJ, 2003, P NATL ACAD SCI USA, V100, P5407, DOI 10.1073/pnas.0931245100
   Smith RAJ, 2008, ANN NY ACAD SCI, V1147, P105, DOI 10.1196/annals.1427.003
   Solesio M.E., 2012, BIOCHIM BIOPHYS ACTA, V1832, P174
   Twig G, 2011, ANTIOXID REDOX SIGN, V14, P1939, DOI 10.1089/ars.2010.3779
   Venkatraman A, 2004, HEPATOLOGY, V40, P565, DOI 10.1002/hep.20326
   Venkatraman A, 2004, J BIOL CHEM, V279, P22092, DOI 10.1074/jbc.M402245200
   Venkatraman A, 2004, AM J PHYSIOL-GASTR L, V286, pG521, DOI 10.1152/ajpgi.00399.2003
   Venkatraman A, 2003, HEPATOLOGY, V38, P141, DOI 10.1053/jhep.2003.50293
   Wu DF, 2010, BIOCHEM BIOPH RES CO, V402, P116, DOI 10.1016/j.bbrc.2010.09.127
   Zafrani ES, 2004, VIRCHOWS ARCH, V444, P3, DOI 10.1007/s00428-003-0943-7
   Zelickson BR, 2011, BBA-BIOENERGETICS, V1807, P1573, DOI 10.1016/j.bbabio.2011.09.011
   Zhang RX, 2010, J EXP CLIN CANC RES, V29, DOI 10.1186/1756-9966-29-130
NR 61
TC 41
Z9 51
U1 0
U2 18
PU PORTLAND PRESS LTD
PI LONDON
PA CHARLES DARWIN HOUSE, 12 ROGER STREET, LONDON WC1N 2JU, ENGLAND
SN 0300-5127
EI 1470-8752
J9 BIOCHEM SOC T
JI Biochem. Soc. Trans.
PD FEB
PY 2013
VL 41
BP 127
EP 133
DI 10.1042/BST20120231
PN 1
PG 7
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 080EB
UT WOS:000314222900020
PM 23356271
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Bus, BAA
   Molendijk, ML
   Penninx, BJWH
   Buitelaar, JK
   Kenis, G
   Prickaerts, J
   Elzinga, BM
   Voshaar, RCO
AF Bus, B. A. A.
   Molendijk, M. L.
   Penninx, B. J. W. H.
   Buitelaar, J. K.
   Kenis, G.
   Prickaerts, J.
   Elzinga, B. M.
   Voshaar, R. C. Oude
TI Determinants of serum brain-derived neurotrophic factor
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Brain-derived neurotrophic factor (BDNF); Determinant; Smoking;
   Sampling; Sociodemographic; Depression
ID FACTOR BDNF; METABOLIC SYNDROME; RAT-BRAIN; PHYSICAL-ACTIVITY;
   FEMALE-PATIENTS; HUMAN PLATELETS; MESSENGER-RNAS; GROWTH-FACTOR; FACTOR
   LEVEL; DEPRESSION
AB Background: Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family of growth factors and affects the survival and plasticity of neurons in the adult central nervous system. The high correlation between cortical and serum BDNF levels has led to many human studies on BDNF levels in various populations, however knowledge about determinants that influence BDNF is lacking.
   Aims: To gain insight into the factors that influence BDNF levels in humans.
   Methods: In 1168 people aged 18 through 65, free of antidepressants and current psychiatric disease, from the Netherlands study of depression and anxiety four categories of determinants (sampling, sociodemographics, lifestyle indicators and diseases) were measured as well as BDNF level. We used univariate analyses as well as multivariate linear regression analyses in particular to determine which of the possible determinants significantly influenced serum BDNF levels.
   Results: The mean BDNF level was 8.98 ng/ml (SD 3.1 ng/ml) with a range from 1.56 ng/ml through 18.50 ng/ml. Our final multivariate regression analysis revealed that a non-fasting state of blood draw (beta = -.067; p = .019), later measurement (beta = -.065; p = .022), longer sample storage (beta = -.082; p = .004) and being a binge drinker (beta = -.063; p = .035) all resulted in attenuated BDNF levels. This was in contrast to smoking (beta = -.098; p = .001) and living in an urban area (beta = .109; p < .001), which resulted in increased BDNF levels. Moreover we found that older subjects also had higher BDNF levels, but this only applied to women (beta = .226; p < .001).
   Conclusions: Future studies on serum levels of BDNF in humans should correct for the time of blood withdrawal, storage, urbanicity, age, sex, smoking status and food and alcohol intake. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Bus, B. A. A.; Buitelaar, J. K.; Voshaar, R. C. Oude] Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, NCEBP, NL-6525 GC Nijmegen, Netherlands.
   [Molendijk, M. L.; Elzinga, B. M.] Leiden Inst Psychol Res, Leiden, Netherlands.
   [Penninx, B. J. W. H.] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Amsterdam, Netherlands.
   [Penninx, B. J. W. H.] Vrije Univ Amsterdam, Med Ctr, EMGO Inst, Amsterdam, Netherlands.
   [Penninx, B. J. W. H.] Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.
   [Penninx, B. J. W. H.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, NL-9713 AV Groningen, Netherlands.
   [Kenis, G.; Prickaerts, J.] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Maastricht, Netherlands.
   [Buitelaar, J. K.] Radboud Univ Nijmegen, Med Ctr, Dept Cognit Neurosci, NL-6525 GC Nijmegen, Netherlands.
C3 Radboud University Nijmegen; Vrije Universiteit Amsterdam; Vrije
   Universiteit Amsterdam; Leiden University - Excl LUMC; Leiden
   University; Leiden University Medical Center (LUMC); University of
   Groningen; Maastricht University; Radboud University Nijmegen
RP Bus, BAA (corresponding author), Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, NCEBP, Reinier Postlaan 10, NL-6525 GC Nijmegen, Netherlands.
EM b.bus@psy.umcn.nl
RI Penninx, Brenda/S-7627-2017; Buitelaar, Jan/AAY-7522-2020
OI Kenis, Gunter/0000-0002-1263-0590; Oude Voshaar,
   Richard/0000-0003-1501-4774; Prickaerts, Jos/0000-0001-5548-731X
FU ZonMW, the Dutch Scientific Organisation-Medical Sciences [10.000.1002];
   GGZ Buitenamstel; GGZ Drenthe; GGZ Friesland; GGZ Geestgronden; GGZ
   Rivierduinen; Lentis; Leiden University Medical Center; University
   Medical Center Groningen; VU University Medical Center; NWO (Dutch
   Scientific Organisation) [016.085.353, 907.0023.1]
FX The NESDA study infrastructure is financed by the Geestkracht program of
   ZonMW, the Dutch Scientific Organisation-Medical Sciences (grant nr.
   10.000.1002) and by complementary funding from participating mental
   healthcare institutions (GGZ Buitenamstel, GGZ Drenthe, GGZ Friesland,
   GGZ Geestgronden, GGZ Rivierduinen, and Lentis) and Universities (Leiden
   University Medical Center, University Medical Center Groningen, and VU
   University Medical Center). BDNF measurements were financed with NWO
   (Dutch Scientific Organisation) VIDI-grant (grant nr. 016.085.353)
   awarded to Dr. Elzinga. Contribution of Dr. Oude Voshaar was made
   possible by a NWO Clinical Fellowship (grant nr. 907.0023.1).
CR Autry AE, 2009, BIOL PSYCHIAT, V66, P84, DOI 10.1016/j.biopsych.2009.02.007
   Aydemir Ö, 2007, PROG NEURO-PSYCHOPH, V31, P1023, DOI 10.1016/j.pnpbp.2007.02.013
   Azoulay D, 2005, J NEUROIMMUNOL, V167, P215, DOI 10.1016/j.jneuroim.2005.07.001
   BABOR TF, 1989, ADDICT BEHAV, V14, P139, DOI 10.1016/0306-4603(89)90043-9
   Bhang SY, 2010, NEUROSCI LETT, V468, P7, DOI 10.1016/j.neulet.2009.10.046
   Binder DK, 2004, GROWTH FACTORS, V22, P123, DOI 10.1080/08977190410001723308
   Brunoni AR, 2008, INT J NEUROPSYCHOPH, V11, P1169, DOI 10.1017/S1461145708009309
   Cai DQ, 2006, PHYSIOL GENOMICS, V24, P191, DOI 10.1152/physiolgenomics.00165.2005
   Chaldakov G.N., 2007, DIABETOLOGIA, V50, P1781
   Chaldakov GN, 2004, PROG BRAIN RES, V146, P279, DOI 10.1016/S0079-6123(03)46018-4
   Chan KL, 2008, NEUROSCI LETT, V447, P124, DOI 10.1016/j.neulet.2008.10.013
   Chao MV, 2003, NAT REV NEUROSCI, V4, P299, DOI 10.1038/nrn1078
   Ciammola A, 2007, AM J MED GENET B, V144B, P574, DOI 10.1002/ajmg.b.30501
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   Currie J, 2009, NEUROSCI LETT, V451, P152, DOI 10.1016/j.neulet.2008.12.043
   Davis MI, 2008, PHARMACOL THERAPEUT, V118, P36, DOI 10.1016/j.pharmthera.2008.01.003
   Donovan MJ, 2000, DEVELOPMENT, V127, P4531
   Ejiri J, 2005, CIRCULATION, V112, P2114, DOI 10.1161/CIRCULATIONAHA.104.476903
   Elfving B, 2010, INT J NEUROPSYCHOPH, V13, P563, DOI 10.1017/S1461145709990721
   ERNFORS P, 1990, NEURON, V5, P511, DOI 10.1016/0896-6273(90)90090-3
   ESTEBAN I, 1995, BRAIN RES BULL, V38, P539, DOI 10.1016/0361-9230(95)02025-9
   Fujimura H, 2002, THROMB HAEMOSTASIS, V87, P728
   Fujinami A, 2008, CLIN BIOCHEM, V41, P812, DOI 10.1016/j.clinbiochem.2008.03.003
   Geroldi D, 2006, MED HYPOTHESES, V67, P195, DOI 10.1016/j.mehy.2006.02.001
   Godfrey R, 2005, CLIN MED, V5, P137, DOI 10.7861/clinmedicine.5-2-137
   Gratacòs M, 2007, BIOL PSYCHIAT, V61, P911, DOI 10.1016/j.biopsych.2006.08.025
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hashimoto K, 2006, PROG NEURO-PSYCHOPH, V30, P1529, DOI 10.1016/j.pnpbp.2006.06.018
   HEATHERTON TF, 1991, BRIT J ADDICT, V86, P1119
   Hiltunen JO, 1996, CIRC RES, V79, P930, DOI 10.1161/01.RES.79.5.930
   Hristova M, 2006, MED HYPOTHESES, V66, P545, DOI 10.1016/j.mehy.2005.08.055
   Ikeda Y, 2008, SCHIZOPHR RES, V101, P58, DOI 10.1016/j.schres.2008.01.017
   Karege F, 2002, NEUROSCI LETT, V328, P261, DOI 10.1016/S0304-3940(02)00529-3
   Karege F, 2002, PSYCHIAT RES, V109, P143, DOI 10.1016/S0165-1781(02)00005-7
   Kerschensteiner M, 1999, J EXP MED, V189, P865, DOI 10.1084/jem.189.5.865
   Kim TS, 2007, NEUROSCI LETT, V423, P53, DOI 10.1016/j.neulet.2007.05.064
   Krabbe KS, 2007, DIABETOLOGIA, V50, P431, DOI 10.1007/s00125-006-0537-4
   Kuzumaki N, 2011, HIPPOCAMPUS, V21, P127, DOI 10.1002/hipo.20775
   Lang UE, 2004, NEUROPSYCHOPHARMACOL, V29, P795, DOI 10.1038/sj.npp.1300382
   Lang UE, 2007, PSYCHOPHARMACOLOGY, V190, P433, DOI 10.1007/s00213-006-0647-1
   Laske C, 2007, J PSYCHIATR RES, V41, P600, DOI 10.1016/j.jpsychires.2006.02.007
   Lommatzsch M, 2005, AM J RESP CRIT CARE, V171, P115, DOI 10.1164/rccm.200406-758OC
   Machado-Vieira R, 2007, BIOL PSYCHIAT, V61, P142, DOI 10.1016/j.biopsych.2006.03.070
   MAISONPIERRE PC, 1990, SCIENCE, V247, P1446, DOI 10.1126/science.2321006
   MAISONPIERRE PC, 1991, GENOMICS, V10, P558, DOI 10.1016/0888-7543(91)90436-I
   Manni L, 2005, INT J CARDIOL, V102, P169, DOI 10.1016/j.ijcard.2004.10.041
   Marano CM, 2007, J CLIN PSYCHIAT, V68, P512, DOI 10.4088/JCP.v68n0404
   Möner R, 2007, WORLD J BIOL PSYCHIA, V8, P141, DOI 10.1080/15622970701263303
   MOLENDIJK ML, 2010, MOL PSYCHIA IN PRESS
   Montag C, 2008, NEUROSCI LETT, V442, P30, DOI 10.1016/j.neulet.2008.06.064
   Monteleone P, 2007, J ASSIST REPROD GEN, V24, P477, DOI 10.1007/s10815-007-9169-y
   Nakahashi T, 2000, FEBS LETT, V470, P113, DOI 10.1016/S0014-5793(00)01302-8
   Nakazato M, 2003, BIOL PSYCHIAT, V54, P485, DOI 10.1016/S0006-3223(02)01746-8
   Nemoto E, 1998, BIOCHEM BIOPH RES CO, V245, P284, DOI 10.1006/bbrc.1998.8418
   NOWAK J, 1987, CIRCULATION, V76, P6, DOI 10.1161/01.CIR.76.1.6
   Pan WH, 1998, NEUROPHARMACOLOGY, V37, P1553, DOI 10.1016/S0028-3908(98)00141-5
   Peen J, 2010, ACTA PSYCHIAT SCAND, V121, P84, DOI 10.1111/j.1600-0447.2009.01438.x
   Penninx BWJH, 2008, INT J METH PSYCH RES, V17, P121, DOI 10.1002/mpr.256
   Piccinni A, 2008, CHRONOBIOL INT, V25, P819, DOI 10.1080/07420520802387773
   ROSENFELD RD, 1995, PROTEIN EXPRES PURIF, V6, P465, DOI 10.1006/prep.1995.1062
   Sartorius A, 2009, PHARMACOPSYCHIATRY, V42, P270, DOI 10.1055/s-0029-1224162
   SCARISBRICK IA, 1993, J NEUROSCI, V13, P875
   Sen S, 2008, BIOL PSYCHIAT, V64, P527, DOI 10.1016/j.biopsych.2008.05.005
   Shimizu E, 2003, BIOL PSYCHIAT, V54, P70, DOI 10.1016/S0006-3223(03)00181-1
   Sohrabji F, 2006, FRONT NEUROENDOCRIN, V27, P404, DOI 10.1016/j.yfrne.2006.09.003
   Suwa M, 2006, METABOLISM, V55, P852, DOI 10.1016/j.metabol.2006.02.012
   Tang SW, 2008, NEUROSCI LETT, V431, P62, DOI 10.1016/j.neulet.2007.11.019
   Trajkovska V, 2007, BRAIN RES BULL, V73, P143, DOI 10.1016/j.brainresbull.2007.03.009
   ULLRICH A, 1990, CELL, V61, P203, DOI 10.1016/0092-8674(90)90801-K
   Umene-Nakano W, 2009, HUM PSYCHOPHARM CLIN, V24, P409, DOI 10.1002/hup.1035
   WITTCHEN HU, 1994, J PSYCHIAT RES, V28, P57, DOI 10.1016/0022-3956(94)90036-1
   Wojnar M, 2009, ALCOHOL CLIN EXP RES, V33, P693, DOI 10.1111/j.1530-0277.2008.00886.x
   YAMAMOTO H, 1990, J NEUROSCI, V10, P3469
   Yasutake C, 2006, EUR ARCH PSY CLIN N, V256, P402, DOI [10.1007/s00406-006-0652-8, 10.1007/s00406-006-0702-2]
   Ziegenhorn AA, 2007, NEUROBIOL AGING, V28, P1436, DOI 10.1016/j.neurobiolaging.2006.06.011
NR 75
TC 243
Z9 251
U1 0
U2 42
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD FEB
PY 2011
VL 36
IS 2
BP 228
EP 239
DI 10.1016/j.psyneuen.2010.07.013
PG 12
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 727VL
UT WOS:000287830900009
PM 20702043
DA 2025-06-11
ER

PT J
AU Elseidy, AMA
   Bashandy, SA
   Ibrahim, FAA
   Abd El-Rahman, SS
   Farid, O
   Moussa, S
   El-Baset, MA
AF Elseidy, Ahmed M. A.
   Bashandy, Samir A.
   Ibrahim, Fatma A. A.
   Abd El-Rahman, Sahar S.
   Farid, Omar
   Moussa, Sherif
   El-Baset, Marwan A.
TI Zinc oxide nanoparticles characterization and therapeutic evaluation on
   high fat/sucrose diet induced-obesity
SO EGYPTIAN JOURNAL OF CHEMISTRY
LA English
DT Article
DE ZnO-Nps; Rietveld analysis; obesity; metabolic syndrome; inflammatory
   markers; oxidative stress
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; METABOLIC SYNDROME;
   SUPPLEMENTATION; PATHOGENESIS; INFLAMMATION; ANTIOXIDANT; MECHANISMS;
   ADIPOKINES; CYTOKINES
AB ZnO/KCl nanocomposite was prepared by solgel to appreciate the role of synthesized ZnO-NPs to curb obesity in a high-fat diet rat model. KCl played an important role in decreasing the particle size (30 nm) and also in facilitating the suspension formation of ZnO-NPs. XRD and HRTEM were carried out to estimate the particle size while SEM was used to investigate the morphology of the nanoparticles. XPS measurements were used to examine the chemical compositions of the nanocomposite. XRD declared that ZnO has a hexagonal wurtzite structure. The Rietveld refinement has also been executed (chi(2) = 1.0 and R-factor was 0.05). The treatment of obese rats with ZnO-NPs enhanced the adiponectin level, hepatic carnitine (Car) and reduced hepatic glutathione (GSH) with lowering the liver enzymes and pathological changes. The treatment coused a decrease in body weight gain, Body mass index (BMI), leptin level, cholesterol, triglycerides, glucose, immunohistochemistry for nuclear factor kappa (NF kappa B), the insulin resistance index (HOMA-IR) and a reduction in hepatic malondialdehyde (MDA), nitric oxide (NO), and 8-Hydroxy-2'-deoxyguanosine (8OHdG). The results indicated a positive correlation between BMI and oxidative stress parameters. In conclusion, ZnO-NPs manifested valuable anti-obesity effects via lowering body weight gain, oxidative stress, BMI, lipids, and insulin resistance.
C1 [Elseidy, Ahmed M. A.] Natl Res Ctr, Inorgan Chem Dept, 33 El Bohouth St,PO 12622, Cairo, Egypt.
   [Bashandy, Samir A.; El-Baset, Marwan A.] Natl Res Ctr, Med Res & Clin Studies Inst, Pharmacol Dept, 33 El Bohouth St,PO 12622, Cairo, Egypt.
   [Ibrahim, Fatma A. A.; Moussa, Sherif] Natl Res Ctr, Biochem Dept, Biotechnol Inst, 33 EL BohouthSt, Cairo, Egypt.
   [Abd El-Rahman, Sahar S.] Cairo Univ, Fac Vet Med, Pathol Dept, Cairo, Egypt.
   [Farid, Omar] Natl Org Drug Control & Res, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); National Research Centre (NRC); Egyptian
   Knowledge Bank (EKB); National Research Centre (NRC); Egyptian Knowledge
   Bank (EKB); National Research Centre (NRC); Egyptian Knowledge Bank
   (EKB); Cairo University; National Organization for Drug Control &
   Research (NODCAR)
RP Elseidy, AMA (corresponding author), Natl Res Ctr, Inorgan Chem Dept, 33 El Bohouth St,PO 12622, Cairo, Egypt.
EM ahmedmaee2@gmail.com
RI El-Seidy, Ahmed/ABH-3277-2021; Ahmed-Farid, Omar/AAE-8278-2022; Sayed,
   Marawan/M-8214-2019
OI El-Seidy, Ahmed/0000-0003-0708-7658; Sayed, Marawan/0000-0002-0861-6251
FU National Research Centre, Cairo, Egypt [12060157]
FX This work is financially supported by National Research Centre, Cairo,
   Egypt (Project No 12060157)
CR Abu Bakar MH, 2015, DIABETES-METAB RES, V31, P453, DOI 10.1002/dmrr.2601
   Ahima RS, 1996, NATURE, V382, P250, DOI 10.1038/382250a0
   Akash MSH, 2018, J CELL BIOCHEM, V119, P105, DOI 10.1002/jcb.26174
   Alzamil H, 2020, J OBES, V2020, DOI 10.1155/2020/5076858
   Antony A, 2018, LASER PHYS, V28, DOI 10.1088/1555-6611/aacd93
   Aydin S, 2014, NUTRITION, V30, P1, DOI 10.1016/j.nut.2013.05.013
   Bagheri S., 2013, Der Pharma Chemica, V5, P265
   Baik I, 2000, AM J EPIDEMIOL, V152, P264, DOI 10.1093/aje/152.3.264
   Bashandy SAE, 2018, CAN J PHYSIOL PHARM, V96, P337, DOI 10.1139/cjpp-2017-0247
   Berg AH, 2001, NAT MED, V7, P947, DOI 10.1038/90992
   Berger S, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/5137947
   Bondia-Pons I, 2012, J PHYSIOL BIOCHEM, V68, P701, DOI 10.1007/s13105-012-0154-2
   Brunt EM, 2010, NAT REV GASTRO HEPAT, V7, P195, DOI 10.1038/nrgastro.2010.21
   Brunt EM, 1999, AM J GASTROENTEROL, V94, P2467, DOI 10.1111/j.1572-0241.1999.01377.x
   Calcaterra V, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10091324
   Chong PW, 2014, PHYTOTHER RES, V28, P1520, DOI 10.1002/ptr.5158
   Das SK, 2011, INDIAN J CLIN BIOCHE, V26, P202, DOI 10.1007/s12291-011-0121-7
   Dogra S, 2019, NANOMED-NANOTECHNOL, V17, P210, DOI 10.1016/j.nano.2019.01.013
   El-Tabl AS, 2012, PHOSPHORUS SULFUR, V187, P1312, DOI 10.1080/10426507.2012.657310
   Fathi M, 2020, BIOL TRACE ELEM RES, V197, P394, DOI 10.1007/s12011-019-02015-8
   Fruebis J, 2001, P NATL ACAD SCI USA, V98, P2005, DOI 10.1073/pnas.041591798
   Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
   Guo CY, 2013, NEURAL REGEN RES, V8, P2003, DOI 10.3969/j.issn.1673-5374.2013.21.009
   Gurzov EN, 2014, CELL METAB, V20, P85, DOI 10.1016/j.cmet.2014.05.011
   Haase H, 2005, BIOMETALS, V18, P333, DOI 10.1007/s10534-005-3707-9
   Hashemipour M, 2009, HORM-INT J ENDOCRINO, V8, P279, DOI 10.14310/horm.2002.1244
   Hui JM, 2004, HEPATOLOGY, V40, P46, DOI 10.1002/hep.20280
   Hulme MA, 2012, DIABETES, V61, P14, DOI 10.2337/db11-1213
   Hurt Ryan T, 2010, Gastroenterol Hepatol (N Y), V6, P780
   Jarrar MH, 2008, ALIMENT PHARM THER, V27, P412, DOI 10.1111/j.1365-2036.2007.03586.x
   Jiang JH, 2018, BIOINORG CHEM APPL, V2018, DOI 10.1155/2018/1062562
   Kerksick C, 2005, J INT SOC SPORT NUTR, V2
   Khokhra R, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-15125-x
   Kim J, 2014, BIOL TRACE ELEM RES, V157, P101, DOI 10.1007/s12011-013-9885-3
   Kujala TS, 2000, J AGR FOOD CHEM, V48, P5338, DOI 10.1021/jf000523q
   Li J, 2019, DIABETOL METAB SYNDR, V11, DOI 10.1186/s13098-019-0410-5
   Lim JS, 2010, NAT REV GASTRO HEPAT, V7, P251, DOI 10.1038/nrgastro.2010.41
   Lodovici M, 1997, TOXICOLOGY, V117, P55, DOI 10.1016/S0300-483X(96)03553-6
   Makki Kassem, 2013, ISRN Inflamm, V2013, P139239, DOI 10.1155/2013/139239
   Marreiro DD, 2006, BIOL TRACE ELEM RES, V112, P109, DOI 10.1385/BTER:112:2:109
   Matsuda M, 2013, OBES RES CLIN PRACT, V7, pE330, DOI 10.1016/j.orcp.2013.05.004
   Mohapatra S, 2020, J EVOL MED DENT SCI-, V9, P1859, DOI 10.14260/jemds/2020/405
   Nagajyothi PC, 2015, J PHOTOCH PHOTOBIO B, V146, P10, DOI 10.1016/j.jphotobiol.2015.02.008
   Olechnowicz J, 2018, J PHYSIOL SCI, V68, P19, DOI 10.1007/s12576-017-0571-7
   Otgonbayar Z, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-020-79469-7
   Parola M, 2011, ANTIOXID REDOX SIGN, V15, P461, DOI 10.1089/ars.2010.3848
   Payahoo L, 2013, ADV PHARM BULL, V3, P161, DOI 10.5681/apb.2013.027
   Petersen KF, 2005, PLOS MED, V2, P879, DOI 10.1371/journal.pmed.0020233
   Polyzos SA, 2010, DIABETES OBES METAB, V12, P365, DOI 10.1111/j.1463-1326.2009.01176.x
   Salata OV, 2004, J Nanobiotechnology, V2, P3, DOI 10.1186/1477-3155-2-3
   Seidell JC, 2015, ANN NUTR METAB, V66, P7, DOI 10.1159/000375143
   TEERLINK T, 1993, ANAL BIOCHEM, V214, P278, DOI 10.1006/abio.1993.1488
   Than NN, 2015, ATHEROSCLEROSIS, V239, P192, DOI 10.1016/j.atherosclerosis.2015.01.001
   Tiniakos DG, 2010, ANNU REV PATHOL-MECH, V5, P145, DOI 10.1146/annurev-pathol-121808-102132
   Wei CC, 2018, FASEB J, V32, P6666, DOI 10.1096/fj.201800463
   Xie FY, 2017, ENDOCR J, V64, P685, DOI 10.1507/endocrj.EJ17-0012
   Yang June S, 2017, BMJ Open Sport Exerc Med, V3, pe000236, DOI 10.1136/bmjsem-2017-000236
   Zaki M., 2014, INT J MEDICAL MED HL, V8, P685
   Zhang Y, 2013, CURR MOL MED, V13, P1633, DOI 10.2174/1566524013666131111130058
NR 59
TC 16
Z9 17
U1 0
U2 2
PU National Information & Documentation Centre-NIDOC
PI CAIRO
PA NIDOC DOKKI, CAIRO, 00000, EGYPT
SN 0449-2285
EI 2357-0245
J9 EGYPT J CHEM
JI Egypt. J. Chem.
PD SEP
PY 2022
VL 65
IS 9
BP 497
EP 511
DI 10.21608/EJCHEM.2022.112166.5113
PG 15
WC Chemistry, Multidisciplinary
WE Emerging Sources Citation Index (ESCI)
SC Chemistry
GA 1S4KZ
UT WOS:000804022400013
OA Bronze
DA 2025-06-11
ER

PT J
AU Malinska, H
   Skop, V
   Trnovska, J
   Markova, I
   Svoboda, P
   Kazdova, L
   Haluzik, M
AF Malinska, H.
   Skop, V.
   Trnovska, J.
   Markova, I.
   Svoboda, P.
   Kazdova, L.
   Haluzik, M.
TI Metformin Attenuates Myocardium Dicarbonyl Stress Induced by Chronic
   Hypertriglyceridemia
SO PHYSIOLOGICAL RESEARCH
LA English
DT Article
DE Hypertriglyceridemia; Dicarbonyl stress; Methylglyoxal; Glyoxalase;
   Metabolic syndrome; Metformin
ID METHYLGLYOXAL IMPAIRS; BETA-HYDROXYBUTYRATE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; ADIPOSE-TISSUE; GLYOXALASE; ACCUMULATION; MECHANISMS;
   GLYCATION; DISEASE
AB Reactive dicarbonyls stimulate production of advanced glycation endproducts, increase oxidative stress and inflammation and contribute to the development of vascular complications. We measured concentrations of dicarbonyls - methylglyoxal (MG), glyoxal (GL) and 3-deoxyglucosone (3-DG) - in the heart and kidney of a model of metabolic syndrome - hereditary hypertriglyceridemic rats (HHTg) and explored its modulation by metformin. Adult HHTg rats were fed a standard diet with or without metformin (300 mg/kg b.w.) and dicarbonyl levels and metabolic parameters were measured. HHTg rats had markedly elevated serum levels of triacylglycerols (p<0.001), FFA (p<0.01) and hepatic triacylglycerols (p<0.001) along with increased concentrations of reactive dicarbonyls in myocardium (MG: p<0.001; GL: p<0.01; 3-DG: p<0.01) and kidney cortex (MG: p<0.01). Metformin treatment significantly reduced reactive dicarbonyls in the myocardium (MG: p<0.05, GL: p<0.05, 3-DG: p<0.01) along with increase of myocardial concentrations of reduced glutathione (p<0.01) and glyoxalase 1 mRNA expression (p<0.05). Metformin did not have any significant effect on dicarbonyls, glutathione or on glyoxalase 1 expression in kidney cortex. Chronically elevated hypertriglyceridemia was associated with increased levels of dicarbonyls in heart and kidney. Beneficial effects of metformin on reactive dicarbonyls and glyoxalase in the heart could contribute to its cardioprotective effects.
C1 [Malinska, H.; Skop, V.; Trnovska, J.; Markova, I.; Kazdova, L.; Haluzik, M.] Inst Clin & Expt Med, Ctr Med Expt, Prague, Czech Republic.
   [Svoboda, P.] Univ Chem & Technol, Dept Biochem & Microbiol, Prague, Czech Republic.
C3 Institute for Clinical & Experimental Medicine (IKEM); University of
   Chemistry & Technology, Prague
RP Malinska, H (corresponding author), Inst Clin & Expt Med, Dept Cardiometab Res, Ctr Expt Med, Videnska 1958, Prague 14021 4, Czech Republic.
EM hana.malinska@ikem.cz
RI Svoboda, Petr/B-7865-2014; Skop, Vojtech/LBI-2231-2024
OI Markova, Irena/0000-0002-4331-7636; Skop, Vojtech/0000-0002-4685-4429;
   Trnovska, Jaroslava/0000-0001-6468-8244
FU Ministry of Health of the Czech Republic - conceptual development of
   research organizations ("Institute for Clinical and Experimental
   Medicine - IKEM") [IN 00023001]
FX This work was supported by the Ministry of Health of the Czech Republic
   - conceptual development of research organizations ("Institute for
   Clinical and Experimental Medicine - IKEM, IN 00023001").
CR Arai Makoto, 2014, Biochem Soc Trans, V42, P491, DOI 10.1042/BST20140010
   Ashour AE, 2012, OXID MED CELL LONGEV, V2012, DOI 10.1155/2012/434195
   Aubert G, 2016, CIRCULATION, V133, P698, DOI 10.1161/CIRCULATIONAHA.115.017355
   DeFronzo R, 2016, METABOLISM, V65, P20, DOI 10.1016/j.metabol.2015.10.014
   Dornadula S, 2015, CHEM RES TOXICOL, V28, P1666, DOI 10.1021/acs.chemrestox.5b00171
   Ferrannini E, 2016, DIABETES CARE, V39, P1108, DOI 10.2337/dc16-0330
   Fleming T, 2012, DIABETOLOGIA, V55, P1151, DOI 10.1007/s00125-012-2452-1
   Foretz M, 2014, CELL METAB, V20, P953, DOI 10.1016/j.cmet.2014.09.018
   Galán A, 2001, J AUTOM METHOD MANAG, V23, P69, DOI 10.1155/S1463924601000086
   Jia XM, 2007, MOL CELL BIOCHEM, V306, P133, DOI 10.1007/s11010-007-9563-x
   Kazdova L, 1997, ANN NY ACAD SCI, V827, P521, DOI 10.1111/j.1749-6632.1997.tb51863.x
   KENDER Z, 2014, DIABETES-METAB RES, V16, P125
   Kinsky OR, 2016, CHEM RES TOXICOL, V29, P227, DOI 10.1021/acs.chemrestox.5b00497
   Maessen DEM, 2015, CLIN SCI, V128, P839, DOI 10.1042/CS20140683
   Malinská H, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0150924
   Malinska H, 2015, NUTRITION, V31, P1045, DOI 10.1016/j.nut.2015.03.011
   Masania J, 2016, GLYCOCONJUGATE J, V33, P581, DOI 10.1007/s10719-016-9692-0
   Matafome P, 2012, ARCH PHYSIOL BIOCHEM, V118, P58, DOI 10.3109/13813455.2012.658065
   Nagao M, 2016, BIOCHEM BIOPH RES CO, V475, P322, DOI 10.1016/j.bbrc.2016.05.097
   Nigro C, 2014, DIABETOLOGIA, V57, P1485, DOI 10.1007/s00125-014-3243-7
   Rabbani N, 2016, GLYCOCONJUGATE J, V33, P513, DOI 10.1007/s10719-016-9705-z
   Rabbani N, 2015, BIOCHEM BIOPH RES CO, V458, P221, DOI 10.1016/j.bbrc.2015.01.140
   Rena G, 2013, DIABETOLOGIA, V56, P1898, DOI 10.1007/s00125-013-2991-0
   Riboulet-Chavey A, 2006, DIABETES, V55, P1289, DOI 10.2337/db05-0857
   Schalkwijk CG, 2015, DIABETOLOGIA, V58, P1715, DOI 10.1007/s00125-015-3597-5
   Sena CM, 2012, PHARMACOL RES, V65, P497, DOI 10.1016/j.phrs.2012.03.004
   Tenenbaum A, 2014, CARDIOVASC DIABETOL, V13, DOI 10.1186/s12933-014-0159-y
   Thornalley PJ, 1999, BIOCHEM J, V344, P109, DOI 10.1042/0264-6021:3440109
   Turk Z, 2011, LIFE SCI, V89, P485, DOI 10.1016/j.lfs.2011.07.021
   Uribarri J, 2015, J CLIN ENDOCR METAB, V100, P1957, DOI 10.1210/jc.2014-3925
   Xue MZ, 2012, BIOCHEM J, V443, P213, DOI 10.1042/BJ20111648
   Zicha J, 2006, PHYSIOL RES, V55, pS49, DOI 10.33549/physiolres.930000.55.S1.49
NR 32
TC 10
Z9 10
U1 0
U2 9
PU ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
PI PRAGUE 4
PA VIDENSKA 1083, PRAGUE 4 142 20, CZECH REPUBLIC
SN 0862-8408
EI 1802-9973
J9 PHYSIOL RES
JI Physiol. Res.
PY 2018
VL 67
IS 2
BP 181
EP 189
DI 10.33549/physiolres.933606
PG 9
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA GE7ZU
UT WOS:000431452400004
PM 29137475
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Yang, X
   Feng, L
   Li, CJ
   Li, Y
AF Yang, Xuan
   Feng, Lei
   Li, Changjiang
   Li, Yu
TI Tranilast Alleviates Endothelial Dysfunctions and Insulin Resistance via
   Preserving Glutathione Peroxidase 1 in Rats Fed a High-Fat Emulsion
SO JOURNAL OF PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE insulin resistance; oxidative stress; endothelial dysfunction;
   tranilast; metabolic syndrome
ID NITRIC-OXIDE SYNTHASE; MUSCLE GLUCOSE-UPTAKE; OXIDATIVE STRESS;
   METABOLIC SYNDROME; SKELETAL-MUSCLE; REACTIVE OXYGEN; VASCULAR
   DYSFUNCTIONS; WEIGHT-GAIN; MARKERS; ATHEROSCLEROSIS
AB We investigated the effects of treatment with tranilast on vascular and metabolic dysfunction induced by a high-fat emulsion intragastric administration. Wistar rats were randomized to receive water or high-fat emulsion with or without tranilast treatment (400 mg/kg per day) for 4 weeks. Insulin sensitivity was determined with a hyperinsulinemic-euglycemic clamp experiment and short insulin tolerance test. Vascular reactivity was evaluated using aortic rings in organ chambers. Glutathione peroxidase 1 (GPX1) expressions, eNOS phosphorylation and activity, MCP-1, H2O2 formation, and NO production were determined in vascular or soleus tissues. Tranilast treatment was found to prevent alterations in vascular reactivity and insulin sensitivity and to prevent increases in plasma glucose and insulin noted in the high-fat emulsion treated rats. These were associated with increased antioxidant enzyme GPX1 expression, eNOS phosphorylation and activity, and NO production, but reductions in H2O2 accumulation. Moreover, tranilast preserved GPX1 expression in palmitic acid (PA)-treated endothelial cells with a consequent decreased ROS formation and increased eNOS phosphorylation and NO production. Therefore, oxidative stress induced by a relatively short-term high-fat diet could cause the early development of vascular and metabolic abnormalities in rats, and tranilast has a beneficial effect in vascular dysfunctions and insulin resistance via preserving GPX1 and alleviating oxidative stress.
C1 [Yang, Xuan] Qingdao Municipal Hosp, Dept Cardiol, Qingdao 266000, Shandong, Peoples R China.
   [Feng, Lei] Qingdao Municipal Hosp, Diagnost Imaging Div, Qingdao 266000, Shandong, Peoples R China.
   [Li, Changjiang] Qingdao Cent Hosp, Intens Care Unit, Qingdao 266042, Shandong, Peoples R China.
   [Li, Yu] Zibo Municipal Hosp Author, Dept Internal Med, Zibo 255000, Shandong, Peoples R China.
C3 Qingdao Municipal Hospital; Qingdao Municipal Hospital
RP Yang, X (corresponding author), Qingdao Municipal Hosp, Dept Cardiol, Qingdao 266000, Shandong, Peoples R China.
EM yangxuan4040@163.com
RI Li, Changjiang/LEL-8637-2024
CR Ai J, 2005, WORLD J GASTROENTERO, V11, P3675, DOI 10.3748/wjg.v11.i24.3675
   Bourgoin F, 2008, AM J PHYSIOL-HEART C, V295, pH1044, DOI 10.1152/ajpheart.00516.2008
   Bourgoin F, 2013, CAN J PHYSIOL PHARM, V91, P547, DOI 10.1139/cjpp-2012-0273
   Caballero AE, 2005, ARCH MED RES, V36, P241, DOI 10.1016/j.arcmed.2005.03.013
   Cai H, 2000, CIRC RES, V87, P840, DOI 10.1161/01.RES.87.10.840
   Chalupsky K, 2005, P NATL ACAD SCI USA, V102, P9056, DOI 10.1073/pnas.0409594102
   Christon R, 2005, METABOLISM, V54, P1600, DOI 10.1016/j.metabol.2005.06.007
   Chrysohoou C, 2007, NUTR METAB CARDIOVAS, V17, P590, DOI 10.1016/j.numecd.2006.05.007
   Clark MG, 2003, AM J PHYSIOL-ENDOC M, V284, pE241, DOI 10.1152/ajpendo.00408.2002
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   Davidson SM, 2007, CIRC RES, V100, P1128, DOI 10.1161/01.RES.0000261970.18328.1d
   Deedwania PC, 2000, J AM COLL CARDIOL, V35, P67, DOI 10.1016/S0735-1097(99)00536-7
   DEFRONZO RA, 1981, DIABETES, V30, P1000, DOI 10.2337/diab.30.12.1000
   DESBUQUOIS B, 1971, J CLIN ENDOCR METAB, V33, P732, DOI 10.1210/jcem-33-5-732
   Evans JL, 2005, ANTIOXID REDOX SIGN, V7, P1040, DOI 10.1089/ars.2005.7.1040
   Flohe L, 1988, Basic Life Sci, V49, P663
   Forgione MA, 2002, CIRCULATION, V106, P1154, DOI 10.1161/01.CIR.0000026820.87824.6A
   Forgione MA, 2002, AM J PHYSIOL-HEART C, V282, pH1255, DOI 10.1152/ajpheart.00598.2001
   Formoso G, 2006, MOL ENDOCRINOL, V20, P1153, DOI 10.1210/me.2005-0266
   Galili O, 2007, AM J PHYSIOL-HEART C, V292, pH904, DOI 10.1152/ajpheart.00628.2006
   Guarino MP, 2006, BRIT J PHARMACOL, V147, P959, DOI 10.1038/sj.bjp.0706691
   Guarino MP, 2004, AM J PHYSIOL-GASTR L, V287, pG527, DOI 10.1152/ajpgi.00085.2004
   Guevara-Patiño A, 2010, J INFECT DEV COUNTR, V4, P521, DOI 10.3855/jidc.718
   Hartwich J, 2007, GENES NUTR, V2, P151, DOI 10.1007/s12263-007-0041-6
   ISHIDA K, 1987, NUCLEIC ACIDS RES, V15, P10051, DOI 10.1093/nar/15.23.10051
   Johnson M, 1998, CLIN THER, V20, P691, DOI 10.1016/S0149-2918(98)80132-X
   KOHLMEIER M, 1986, CLIN CHEM, V32, P63
   Korystov YN, 2009, FREE RADICAL RES, V43, P149, DOI 10.1080/10715760802644686
   López D, 2004, AM J PHYSIOL-HEART C, V287, pH567, DOI 10.1152/ajpheart.01145.2003
   Lubos E, 2011, J BIOL CHEM, V286, P35407, DOI 10.1074/jbc.M110.205708
   Madamanchi NR, 2007, CIRC RES, V100, P460, DOI 10.1161/01.RES.0000258450.44413.96
   Mamputu JC, 2003, DIABETES METAB, V29, pS71
   Mano T, 1996, AM HEART J, V131, P231, DOI 10.1016/S0002-8703(96)90346-4
   Matsumura T, 1999, CIRCULATION, V99, P919, DOI 10.1161/01.CIR.99.7.919
   McGovern PG, 1996, NEW ENGL J MED, V334, P884, DOI 10.1056/NEJM199604043341403
   Merry TL, 2010, AM J PHYSIOL-ENDOC M, V298, pE577, DOI 10.1152/ajpendo.00239.2009
   Miatello R, 2001, AM J HYPERTENS, V14, P1135, DOI 10.1016/S0895-7061(01)02206-3
   Milagro FI, 2006, OBESITY, V14, P1118, DOI 10.1038/oby.2006.128
   Mohanty P, 2002, AM J CLIN NUTR, V75, P767, DOI 10.1093/ajcn/75.4.767
   Namazi MR, 2005, MED HYPOTHESES, V64, P1135, DOI 10.1016/j.mehy.2003.11.047
   PALMER RMJ, 1987, NATURE, V327, P524, DOI 10.1038/327524a0
   Pendergrass M, 2007, AM J PHYSIOL-ENDOC M, V292, pE92, DOI 10.1152/ajpendo.00617.2005
   Piga R, 2007, ATHEROSCLEROSIS, V193, P328, DOI 10.1016/j.atherosclerosis.2006.09.016
   Pihl E, 2006, INT J OBESITY, V30, P141, DOI 10.1038/sj.ijo.0803068
   Piva SJ, 2011, CLIN BIOCHEM, V44, P345, DOI 10.1016/j.clinbiochem.2010.12.001
   RICHTERI.R, 1974, Z KLIN CHEM KLIN BIO, V12, P5
   Rizvi AA, 2007, CHINESE MED J-PEKING, V120, P1918, DOI 10.1097/00029330-200711010-00014
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Russell-Jones D, 2007, DIABETES OBES METAB, V9, P799, DOI 10.1111/j.1463-1326.2006.00686.x
   Saiura A, 2001, EUR J PHARMACOL, V433, P163, DOI 10.1016/S0014-2999(01)01501-1
   Scarpello JHB, 2003, DIABETES METAB, V29, pS36
   Shinozaki K, 1999, DIABETES, V48, P2437, DOI 10.2337/diabetes.48.12.2437
   Stocker R, 2004, PHYSIOL REV, V84, P1381, DOI 10.1152/physrev.00047.2003
   THIEBAUD D, 1982, DIABETES, V31, P957, DOI 10.2337/diacare.31.11.957
   TOOKE JE, 1995, DIABETES, V44, P721, DOI 10.2337/diabetes.44.7.721
   Tracy RP, 2003, INT J CLIN PRACT, P10
   Troyer DA, 1997, CLIN EXP IMMUNOL, V108, P58, DOI 10.1046/j.1365-2249.1997.d01-970.x
   Utriainen T, 1998, DIABETOLOGIA, V41, P555, DOI 10.1007/s001250050946
   Vincent MA, 2004, DIABETES, V53, P1418, DOI 10.2337/diabetes.53.6.1418
   Wang LM, 2008, AM J PHYSIOL-HEART C, V295, pH237, DOI 10.1152/ajpheart.01366.2007
   Wu B, 2009, ENDOCR J, V56, P773, DOI 10.1507/endocrj.K08E-332
NR 61
TC 8
Z9 10
U1 0
U2 10
PU JAPANESE PHARMACOLOGICAL SOC
PI KYOTO
PA EDITORIAL OFF, KANTOHYA BLDG GOKOMACHI-EBISUGAWA NAKAGYO-KU, KYOTO, 604,
   JAPAN
SN 1347-8613
EI 1347-8648
J9 J PHARMACOL SCI
JI J. Pharmacol. Sci.
PD JAN
PY 2014
VL 124
IS 1
BP 18
EP 30
DI 10.1254/jphs.13151FP
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 299UT
UT WOS:000330421900003
PM 24389817
OA Bronze
DA 2025-06-11
ER

PT J
AU Ionita-Radu, F
   Ranetti, AE
   Vasile, TM
   Sirbu, AM
   Axelerad, A
   Sirbu, CA
AF Ionita-Radu, Florentina
   Ranetti, Aurelian E.
   Vasile, Titus M.
   Sirbu, Anca M.
   Axelerad, Any
   Sirbu, Carmen A.
TI The Impact of the Hypercaloric Diet versus the Mediterranean Diet on
   Insulin Sensitivity
SO ROMANIAN JOURNAL OF MILITARY MEDICINE
LA English
DT Article
DE obesity; diet; MetS; insulin; metaflammation
ID LOW-CARBOHYDRATE DIETS; METABOLIC SYNDROME; DIABETES-MELLITUS;
   RESISTANCE; OBESITY; PREVENTION; INTERVENTION; INFLAMMATION
AB Obesity affects the population worldwide. A hypercaloric diet associated with a sedentary life, stress, and genetic background, triggers various metabolic disorders, such as metabolic syndrome, diabetes mellitus, cancer, cardiovascular diseases, non-alcoholic fatty liver disease, and cognitive impairment. A healthy diet correlated with physical activity, not smoking, and moderate alcohol consumption reduces the risk of developing metabolic diseases. The Mediterranean diet contains antioxidants, fiber, polyunsaturated fats, and compounds with anti-inflammatory, anti-oxidant, anti-cancer, and anti-obesity properties. In a wide variety of species including humans, the reduction of calories between 20-40% significantly improves health, increases longevity, and delays the development of various pathologies. The main aim of this review is to present the comparative effects of the Mediterranean diet versus the hypercaloric diet on insulin sensitivity.
C1 [Ionita-Radu, Florentina] Carol Davila Cent Mil Emergency Univ Hosp, Gastroenterol Clin, Bucharest, Romania.
   [Ionita-Radu, Florentina] Carol Davila Univ Med & Pharm, Dept Internal Med & Gastroenterol, Bucharest, Romania.
   [Ranetti, Aurelian E.] Carol Davila Univ Med & Pharm, Dept Endocrinol, Bucharest, Romania.
   [Ranetti, Aurelian E.] Carol Davila Cent Mil Emergency Univ Hosp, Endocrinol Clin, Bucharest, Romania.
   [Vasile, Titus M.; Sirbu, Carmen A.] Univ Med & Pharm Carol Davila, Clin Neurosci Dept, Bucharest, Romania.
   [Sirbu, Anca M.] NovaLife Clin, Bucharest, Romania.
   [Axelerad, Any] Ovidius Univ, Gen Med Fac, Dept Neurol, Constanta, Romania.
   [Sirbu, Carmen A.] Dr Carol Davila Cent Mil Emergency Univ Hosp, Neurol Clin, Bucharest, Romania.
   [Sirbu, Carmen A.] Victor Babes Univ Med & Pharm, Fac Med, Ctr Cognit Res Neuropsychiat Pathol Neuropsy Cog, Dept Neurol, Timisoara, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy; Carol Davila University of Medicine & Pharmacy;
   Ovidius University; Victor Babes University of Medicine & Pharmacy,
   Timisoara
RP Ranetti, AE (corresponding author), Carol Davila Univ Med & Pharm, Dept Endocrinol, Bucharest, Romania.; Ranetti, AE (corresponding author), Carol Davila Cent Mil Emergency Univ Hosp, Endocrinol Clin, Bucharest, Romania.
EM aurelian.ranetti@umfcd.ro
RI SIRBU, Carmen Adella/AAA-9317-2020; AXELERAD, ANY/F-5825-2012; Vasile,
   Mihai/G-3027-2011; Ionita-Radu, Florentina/ADP-0898-2022; Ranetti,
   Aurelian-Emil/JQV-7664-2023
OI Ranetti, Aurelian-Emil/0009-0006-1028-0618
CR Abenavoli L, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16173011
   Adam-Perrot A, 2006, OBES REV, V7, P49, DOI 10.1111/j.1467-789X.2006.00222.x
   Adeva-Andany MM, 2019, CLIN NUTR ESPEN, V33, P29, DOI 10.1016/j.clnesp.2019.05.014
   Almeda-Valdes P, 2019, CURR MED CHEM, V26, P3613, DOI 10.2174/0929867324666170518095316
   Avgerinos KI, 2019, METABOLISM, V92, P121, DOI 10.1016/j.metabol.2018.11.001
   Balaban DV, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000000726
   Bleach R, 2021, FRONT CELL DEV BIOL, V9, DOI 10.3389/fcell.2021.630503
   Canfora EE, 2015, NAT REV ENDOCRINOL, V11, P577, DOI 10.1038/nrendo.2015.128
   Capurso C, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010035
   Chiba T, 2007, CURR GENOMICS, V8, P423, DOI 10.2174/138920207783591726
   Chiefari E, 2017, J ENDOCRINOL INVEST, V40, P899, DOI 10.1007/s40618-016-0607-5
   Clifton P, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071438
   D'Souza MS, 2020, AM J MED, V133, P1126, DOI 10.1016/j.amjmed.2020.05.017
   Delgado-Lista J, 2016, AM HEART J, V177, P42, DOI 10.1016/j.ahj.2016.04.011
   Di Daniele N, 2017, ONCOTARGET, V8, P8947, DOI 10.18632/oncotarget.13553
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   Festi D, 2014, WORLD J GASTROENTERO, V20, P16079, DOI 10.3748/wjg.v20.i43.16079
   Finicelli M, 2019, J CELL PHYSIOL, V234, P5807, DOI 10.1002/jcp.27506
   Golabek KD, 2019, ADV CLIN EXP MED, V28, P1577, DOI 10.17219/acem/109976
   Green M, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21082890
   Guasch-Ferré M, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/6723931
   Gupta A, 2010, BIOSCI TRENDS, V4, P204
   Hansen D, 2017, SPORTS MED, V47, P415, DOI 10.1007/s40279-016-0594-x
   Iftimie G, 2018, ROM J MIL MED, V121, P9
   Janiszewska J, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113491
   Janssen JAMJL, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22157797
   Jung CH, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040322
   Kahleova H, 2020, NUTRIENTS, V12, DOI 10.3390/nu12102917
   Koliaki C, 2019, METABOLISM, V92, P98, DOI 10.1016/j.metabol.2018.10.011
   Lauterbach MAR, 2017, PFLUG ARCH EUR J PHY, V469, P385, DOI 10.1007/s00424-017-1955-5
   Lebovitz HE, 2001, EXP CLIN ENDOCR DIAB, V109, pS135, DOI 10.1055/s-2001-18576
   Martinez-Herrera M, 2017, MED ORAL PATOL ORAL, V22, pE708, DOI 10.4317/medoral.21786
   Mattson MP, 2017, AGEING RES REV, V39, P46, DOI 10.1016/j.arr.2016.10.005
   Meikle PJ, 2017, NAT REV ENDOCRINOL, V13, P79, DOI 10.1038/nrendo.2016.169
   Mirabelli M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12103042
   Mirabelli M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041066
   Miricescu D, 2021, EXP THER MED, V21, DOI 10.3892/etm.2021.9969
   Miricescu D, 2021, EXP THER MED, V21, DOI 10.3892/etm.2021.9972
   Miricescu D, 2020, J MIND MED SCI, V7, P34, DOI 10.22543/7674.71.P3439
   Miricescu D, 2019, ROM J LEG MED, V27, P217, DOI 10.4323/rjlm.2019.217
   Miricescu D, 2019, MATER PLAST, V56, P520
   O'Neill BJ, 2020, CURR OPIN ENDOCRINOL, V27, P301, DOI 10.1097/MED.0000000000000569
   Papadaki A, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113342
   Polsky S, 2015, CURR OPIN ENDOCRINOL, V22, P277, DOI 10.1097/MED.0000000000000170
   Radulescu C, 2019, MATER PLAST, V56, P937
   Roeb E, 2019, Z GASTROENTEROL, V57, P508, DOI [10.1055/a-0784-8877, 10.1055/a-0784-8827]
   Ros E, 2014, ADV NUTR, V5, p330S, DOI 10.3945/an.113.005389
   Russell WR, 2016, CRIT REV FOOD SCI, V56, P541, DOI 10.1080/10408398.2013.792772
   Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012
   Sayón-Orea C, 2019, JAMA-J AM MED ASSOC, V322, P1486, DOI 10.1001/jama.2019.14630
   Sevrin T, 2020, GENES-BASEL, V11, DOI 10.3390/genes11101208
   Silvestris E, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00346
   Stanescu AMA, 2019, ROM J MIL MED, V122, P85
   Stanescu AMA, 2019, REV CHIM-BUCHAREST, V70, P2072
   Stanhope KL, 2016, CRIT REV CL LAB SCI, V53, P52, DOI 10.3109/10408363.2015.1084990
   Stefani C, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms221910260
   Trepanowski JF, 2010, NUTR J, V9, DOI 10.1186/1475-2891-9-57
   Volaco A, 2018, CURR DIABETES REV, V14, P321, DOI 10.2174/1573399813666170621123227
   Wang S, 2014, J NUTR BIOCHEM, V25, P1, DOI 10.1016/j.jnutbio.2013.09.001
   Weickert MO, 2018, J NUTR, V148, P7, DOI 10.1093/jn/nxx008
   Willems AEM, 2021, NUTR REV, V79, P429, DOI 10.1093/nutrit/nuaa044
   Yazici D, 2017, ADV EXP MED BIOL, V960, P277, DOI 10.1007/978-3-319-48382-5_12
NR 62
TC 0
Z9 0
U1 0
U2 2
PU CAROL DAVILA UNIV MEDICINE & PHARMACY PUBL
PI BUCHAREST
PA STR INST MEDICO-MILITAR, NR 3-5, SECTOR 1, BUCHAREST, 010919, ROMANIA
SN 1222-5126
EI 2501-2312
J9 ROM J MIL MED
JI Rom. J. Milit. Med.
PD AUG
PY 2023
VL 126
IS 3
BP 275
EP 280
DI 10.55453/rjmm.2023.126.3.6
PG 6
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA T4AH1
UT WOS:001077425400005
DA 2025-06-11
ER

PT J
AU Omu, AE
AF Omu, Alexander E.
TI Sperm Parameters: Paradigmatic Index of Good Health and Longevity
SO MEDICAL PRINCIPLES AND PRACTICE
LA English
DT Review
DE Spermatozoa parameters; Longevity; Oxidative stress; Low testosterone
ID TESTICULAR DYSGENESIS SYNDROME; BODY-MASS INDEX; HORMONE-BINDING
   GLOBULIN; LIFE-STYLE FACTORS; SEMEN QUALITY; METABOLIC SYNDROME;
   OXIDATIVE STRESS; DNA-DAMAGE; TESTOSTERONE LEVELS; INSULIN-RESISTANCE
AB Since the discovery of spermatozoon by Anton van Leeuwenhoek in 1677, there has been an ever increasing understanding of its role in reproduction. Many factors adversely affect sperm quality, including varicocele, accessory gland infection, immunological factors, congenital abnormalities, and iatrogenic systemic and endocrine causes, such as diabetes mellitus, obesity, metabolic syndrome, and smoking. The mechanisms responsible for the association between poor sperm parameters and ill health may include oxidative stress, low-grade inflammation, low testosterone, and low sex-hormone-binding globulin. Oxidative stress in the testicular microenvironment may result in decreased spermatogenesis and sperm DNA damage, loss of sperm motility, and abnormal sperm morphology. Low testosterone caused by advanced age, visceral obesity, and inflammation is associated with the development of cardiovascular disease. Hence, semen analysis has an important role in the routine evaluation of idiopathic male infertility, usually manifested as low sperm counts, impaired sperm motility, or absence of sperm, and remains the most common single diagnostic tool. Several studies have shown an inverse relationship between semen quality and medical disorders. This review elucidates the effect of medical disorders and social habits on sperm quality, the mechanisms that are involved in the impairment of sperm quality, and whether or not sperm quality can be used as an index of good health and longevity in a man. (C) 2013 S. Karger AG, Basel
C1 Kuwait Univ, Fac Med, Dept Obstet & Gynecol, Hlth Sci Ctr, Safat 13110, Kuwait.
C3 Kuwait University
RP Omu, AE (corresponding author), Kuwait Univ, Fac Med, Dept Obstet & Gynecol, Hlth Sci Ctr, POB 24923, Safat 13110, Kuwait.
EM Omu@hsc.edu.kw
FU Research Sector, Kuwait University [MO031, 033, 254]
FX I am grateful to the Research Sector, Kuwait University, for research
   grants MO031, 033, and 254, which made this review possible. The
   technicians in my department and my medical colleagues and nurses at the
   Maternity Hospital worked with me with absolute dedication and
   professionalism. I acknowledge with gratitude the loyalty and
   contribution of all the patients from my clinic.
CR Agbaje IM, 2007, HUM REPROD, V22, P1871, DOI 10.1093/humrep/dem077
   Aggerholm AS, 2008, FERTIL STERIL, V90, P619, DOI 10.1016/j.fertnstert.2007.07.1292
   Aitken R John, 2003, Reprod Biomed Online, V7, P65
   Aitken RJ, 2009, INT J ANDROL, V32, P46, DOI 10.1111/j.1365-2605.2008.00943.x
   Aitken RJ, 2001, REPRODUCTION, V122, P497, DOI 10.1530/rep.0.1220497
   Al-Azemi MK, 2009, REPROD BIOMED ONLINE, V19, P583, DOI 10.1016/j.rbmo.2009.05.005
   Al-Bader A, 1999, ARCH ANDROLOGY, V43, P135, DOI 10.1080/014850199262643
   Al-Sweih NA, 2012, J ANDROL, V33, P1331, DOI 10.2164/jandrol.111.016212
   Al-Sweih NA, 2012, J ANDROL, V33, P1323, DOI 10.2164/jandrol.111.013821
   Alvarez C, 2003, HUM REPROD, V18, P2082, DOI 10.1093/humrep/deg430
   Anderson K, 2010, AUST NZ J OBSTET GYN, V50, P8, DOI 10.1111/j.1479-828X.2009.01119.x
   [Anonymous], 1948, INT HLTH C NEW YORK
   [Anonymous], 2010, WHO Laboratory Manual for the Examination and Processing of Human Semen
   Atkinson AJ, 2001, CLIN PHARMACOL THER, V69, P89, DOI 10.1067/mcp.2000.113989
   AUGER J, 1995, NEW ENGL J MED, V332, P281, DOI 10.1056/NEJM199502023320501
   Baccetti B, 2002, HUM REPROD, V17, P2673, DOI 10.1093/humrep/17.10.2673
   Baker JA, 2005, CANCER CAUSE CONTROL, V16, P295, DOI 10.1007/s10552-004-4024-2
   Bakos HW, 2011, INT J ANDROL, V34, P402, DOI 10.1111/j.1365-2605.2010.01092.x
   Barker DJP, 2004, J AM COLL NUTR, V23, p588S, DOI 10.1080/07315724.2004.10719428
   Bax T, 1999, AM FAM PHYSICIAN, V59, P143
   Bendavid Robert, 2004, Hernia, V8, P171
   BENOFF S, 1994, FERTIL STERIL, V62, P606
   Bingener J, 2007, ARCH SURG-CHICAGO, V142, P562, DOI 10.1001/archsurg.142.6.562
   Bonde JPE, 1998, LANCET, V352, P1172, DOI 10.1016/S0140-6736(97)10514-1
   BRACKEN MB, 1990, FERTIL STERIL, V53, P315
   Brand JS, 2011, INT J EPIDEMIOL, V40, P189, DOI 10.1093/ije/dyq158
   Brewis IA, 2010, MOL HUM REPROD, V16, P68, DOI 10.1093/molehr/gap077
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Burns WR, 2010, INT BRAZ J UROL, V36, P527, DOI 10.1590/S1677-55382010000500002
   CARLSEN E, 1995, ENVIRON HEALTH PERSP, V103, P137, DOI 10.2307/3432523
   CARLSEN E, 1992, BRIT MED J, V305, P609, DOI 10.1136/bmj.305.6854.609
   Celino FT, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016938
   Centola GM, 1999, FERTIL STERIL, V72, P803, DOI 10.1016/S0015-0282(99)00395-7
   Chavarro JE, 2010, FERTIL STERIL, V93, P2222, DOI 10.1016/j.fertnstert.2009.01.100
   Chubb SAP, 2008, EUR J ENDOCRINOL, V158, P785, DOI 10.1530/EJE-07-0893
   Chung E, 2011, CUAJ-CAN UROL ASSOC, V5, P210, DOI 10.5489/cuaj.10106
   Chung WS, 1999, EUR UROL, V36, P68, DOI 10.1159/000019929
   CLOSE CE, 1990, J UROLOGY, V144, P900, DOI 10.1016/S0022-5347(17)39618-0
   Dada Rima, 2004, J Biomol Tech, V15, P176
   Dallmeier D, 2012, DIABETOL METAB SYNDR, V4, DOI 10.1186/1758-5996-4-28
   Dobell C, 1960, A VANLEEUWENHOEK HIS, P388
   Du Plessis SKA, 2011, OPEN REPROD SCI J, V3, P92
   Du Plessis SS, 2010, NAT REV UROL, V7, P153, DOI 10.1038/nrurol.2010.6
   Duffy MJ, 2013, MED PRIN PRACT, V22, P4, DOI 10.1159/000338393
   Ellis SM, 2006, WHO MANUAL DIAGNOSTI
   Emanuela F, 2012, J NUTR METAB, V2012, DOI 10.1155/2012/476380
   Eskenazi B, 2003, HUM REPROD, V18, P447, DOI 10.1093/humrep/deg107
   Evans JL, 2003, DIABETES, V52, P1, DOI 10.2337/diabetes.52.1.1
   Evenson DP, 1999, HUM REPROD, V14, P1039, DOI 10.1093/humrep/14.4.1039
   Fariello RM, 2012, BJU INT, V110, P863, DOI 10.1111/j.1464-410X.2011.10813.x
   Fawzy Irene A., 2011, Research Journal of Environmental Toxicology, V5, P282, DOI 10.3923/rjet.2011.282.292
   Frank N, 2006, B ECOL SOC AM, V87, P47
   Gharagozloo P, 2011, HUM REPROD, V26, P1628, DOI 10.1093/humrep/der132
   GIWERCMAN A, 1987, J UROLOGY, V138, P1214, DOI 10.1016/S0022-5347(17)43553-1
   Gorbachinsky Ilya, 2010, Rev Urol, V12, pe157
   Groos S, 2004, Andrologia, V36, P169
   Grundy E, 2005, SOC SCI MED, V61, P217, DOI 10.1016/j.socscimed.2004.11.046
   Grundy E, 2008, AM J EPIDEMIOL, V167, P271, DOI 10.1093/aje/kwm295
   HAFFNER SM, 1993, J CLIN ENDOCR METAB, V77, P1610, DOI 10.1210/jc.77.6.1610
   Hammoud AO, 2008, FERTIL STERIL, V90, P897, DOI 10.1016/j.fertnstert.2008.08.026
   HOLZKI G, 1991, ANDROLOGIA, V23, P141
   HURD WW, 1992, FERTIL STERIL, V57, P178
   Irvine DS, 1998, HUM REPROD, V13, P33, DOI 10.1093/humrep/13.suppl_1.33
   Jensen MD, 2006, EUR HEART J SUPPL, V8, pB13, DOI 10.1093/eurheartj/sul003
   Jensen TK, 2009, AM J EPIDEMIOL, V170, P559, DOI 10.1093/aje/kwp168
   Jorgensen N, 2001, HUM REPROD, V16, P1012, DOI 10.1093/humrep/16.5.1012
   Kapoor D, 2007, INT J ANDROL, V30, P500, DOI 10.1111/j.1365-2605.2007.00744.x
   Kapoor D, 2005, CLIN ENDOCRINOL, V63, P239, DOI 10.1111/j.1365-2265.2005.02299.x
   Kasturi SS, 2008, J ANDROL, V29, P251, DOI 10.2164/jandrol.107.003731
   Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2548, DOI 10.1210/jc.2004-0395
   Khaki Arash, 2008, Pak J Biol Sci, V11, P1683, DOI 10.3923/pjbs.2008.1683.1689
   Khaw KT, 2007, CIRCULATION, V116, P2694, DOI 10.1161/CIRCULATIONAHA.107.719005
   Kidd SA, 2001, FERTIL STERIL, V75, P237, DOI 10.1016/S0015-0282(00)01679-4
   Kirkman-Brown JC, 2003, DEV BIOL, V259, P71, DOI 10.1016/S0012-1606(03)00137-4
   Kjærbye-Thygesen A, 2006, CANCER EPIDEM BIOMAR, V15, P798, DOI 10.1158/1055-9965.EPI-05-0897
   Kort HI, 2006, J ANDROL, V27, P450, DOI 10.2164/jandrol.05124
   Künzle R, 2003, FERTIL STERIL, V79, P287, DOI 10.1016/S0015-0282(02)04664-2
   Laaksonen DE, 2003, EUR J ENDOCRINOL, V149, P601, DOI 10.1530/eje.0.1490601
   Lamb DJ, 2010, ASIAN J ANDROL, V12, P64, DOI 10.1038/aja.2009.4
   Lazaros L, 2011, FERTIL STERIL, V95, P110, DOI 10.1016/j.fertnstert.2010.05.012
   Lenzi A, 1996, HUM REPROD UPDATE, V2, P246, DOI 10.1093/humupd/2.3.246
   Lewis SEM, 2010, HUM FERTIL, V13, P201, DOI 10.3109/14647273.2010.528823
   Li CY, 2010, DIABETES CARE, V33, P1618, DOI 10.2337/dc09-1788
   Lorusso F, 2010, ANDROLOGIA, V42, P121, DOI 10.1111/j.1439-0272.2009.00970.x
   Ma RCW, 2010, HEART, V96, P1787, DOI 10.1136/hrt.2010.207068
   MacLeod J, 1943, AM J PHYSIOL, V138, P0512, DOI 10.1152/ajplegacy.1943.138.3.512
   Magnusdottir EV, 2005, HUM REPROD, V20, P208, DOI 10.1093/humrep/deh569
   Main KM, 2009, ENDOCR DEV, V14, P167, DOI 10.1159/000207485
   Malik S, 2005, DIABETES CARE, V28, P690, DOI 10.2337/diacare.28.3.690
   Malkin CJ, 2004, J CLIN ENDOCR METAB, V89, P3313, DOI 10.1210/jc.2003-031069
   Mammi C, 2012, INT J ENDOCRINOL, V2012, DOI 10.1155/2012/789653
   Marinelli D, 2004, INT J HYG ENVIR HEAL, V207, P185, DOI 10.1078/1438-4639-00283
   Mazzoli S, 2010, EUR UROL, V57, P708, DOI 10.1016/j.eururo.2009.05.015
   McEwen Bruce S, 2006, Dialogues Clin Neurosci, V8, P367
   McMillen IC, 2005, PHYSIOL REV, V85, P571, DOI 10.1152/physrev.00053.2003
   Meigs JB, 2009, DIABETES CARE, V32, P1346, DOI 10.2337/dc09-0754
   MEIROW D, 1995, HUM REPROD, V10, P2017, DOI 10.1093/oxfordjournals.humrep.a136228
   Moller H, 1999, BMJ-BRIT MED J, V318, P559, DOI 10.1136/bmj.318.7183.559
   Muciaccia B, 2012, HUM REPROD, V27, P2267, DOI 10.1093/humrep/des173
   Murphy F, 2007, PEDIATR SURG INT, V23, P625, DOI 10.1007/s00383-007-1900-3
   Nagathihalli NS, 2012, MOL CANCER THER, V11, P2362, DOI 10.1158/1535-7163.MCT-12-0107
   NEAGU M, 2013, BIOMARK MED, V7, P201
   Nguyen RHN, 2007, HUM REPROD, V22, P2488, DOI 10.1093/humrep/dem139
   Okoror LE, 2012, J MED MICROB DIAGN, V1, P108
   OLSEN GW, 1995, FERTIL STERIL, V63, P887, DOI 10.1016/S0015-0282(16)57498-6
   Omu AE, 1998, J REPROD MED, V43, P857
   Omu AE, 1998, EUR J OBSTET GYN R B, V79, P179, DOI 10.1016/S0301-2115(97)00262-5
   Omu AE, 1998, MED PRIN PRACT, V7, P47, DOI 10.1159/000026021
   Omu AE, 2013, HSC C KUW
   Omu AE, 2007, ANDROL UPDATE, V1, P157
   Osuna JA, 2006, ARCH ANDROLOGY, V52, P355, DOI 10.1080/01485010600692017
   Ozer JS, 2010, NAT BIOTECHNOL, V28, P486, DOI 10.1038/nbt.1627
   Paulson RJ, 2001, AM J OBSTET GYNECOL, V184, P818, DOI 10.1067/mob.2001.113852
   PAYNE JH, 1994, ARCH SURG-CHICAGO, V129, P973
   Pinto-Correia C, 1993, OVARY EVE EGG SPERM, P74
   Santos EP, 2011, ANDROLOGIA, V43, P431, DOI 10.1111/j.1439-0272.2010.01089.x
   Qin DD, 2007, ASIAN J ANDROL, V9, P827, DOI 10.1111/j.1745-7262.2007.00268.x
   Rabe K, 2008, MOL MED, V14, P741, DOI 10.2119/2008-00058.Rabe
   Raman JD, 2005, J UROLOGY, V174, P1819, DOI 10.1097/01.ju.0000177491.98461.aa
   Ramlau-Hansen CH, 2007, HUM REPROD, V22, P1634, DOI 10.1093/humrep/dem035
   Ridgway PF, 2002, BJU INT, V90, P272, DOI 10.1046/j.1464-410X.2002.02844.x
   Robeva R, 2006, ANDROLOGIA, V38, P216, DOI 10.1111/j.1439-0272.2006.00743.x
   Rolf C, 1999, HUM REPROD, V14, P1028, DOI 10.1093/humrep/14.4.1028
   Sallmén M, 2006, EPIDEMIOLOGY, V17, P520, DOI 10.1097/01.ede.0000229953.76862.e5
   Sharpe RM, 2002, NAT CELL BIOL, V4, pS33, DOI 10.1038/ncb-nm-fertilityS33
   Sharpe RM, 2001, TOXICOL LETT, V120, P221, DOI 10.1016/S0378-4274(01)00298-3
   Shin MJ, 2009, CLIN CHIM ACTA, V405, P139, DOI 10.1016/j.cca.2009.04.020
   Shores MM, 2006, ARCH INTERN MED, V166, P1660, DOI 10.1001/archinte.166.15.1660
   Siddiqui IA, 2013, BIOMARK MED, V7, P229, DOI [10.2217/bmm.12.109, 10.2217/BMM.12.109]
   Siva AB, 2010, MOL HUM REPROD, V16, P452, DOI 10.1093/molehr/gaq009
   Skakkebæk NE, 2001, HUM REPROD, V16, P972, DOI 10.1093/humrep/16.5.972
   Skakkebæk NE, 2004, INT J ANDROL, V27, P189, DOI 10.1111/j.1365-2605.2004.00488.x
   SOFIKITIS N, 1995, J UROLOGY, V154, P1030, DOI 10.1016/S0022-5347(01)66968-4
   Svartberg J, 2004, EUR J ENDOCRINOL, V150, P65, DOI 10.1530/eje.0.1500065
   Taube A, 2012, AM J PHYSIOL-HEART C, V302, pH2148, DOI 10.1152/ajpheart.00907.2011
   TIEPOLO L, 1976, HUM GENET, V34, P119, DOI 10.1007/BF00278879
   Tomar AK, 2012, PROTEOM CLIN APPL, V6, P147, DOI 10.1002/prca.201100084
   Tong PCY, 2005, J CLIN ENDOCR METAB, V90, P6418, DOI 10.1210/jc.2005-0228
   Toppari J, 2001, HUM REPROD UPDATE, V7, P282, DOI 10.1093/humupd/7.3.282
   Toppari J, 2010, BIRTH DEFECTS RES A, V88, P910, DOI 10.1002/bdra.20707
   Tremellen K, 2008, HUM REPROD UPDATE, V14, P243, DOI 10.1093/humupd/dmn004
   Trsinar B, 2009, WORLD J UROL, V27, P513, DOI 10.1007/s00345-009-0406-0
   Turner TT, 2008, J ANDROL, V29, P237, DOI 10.2164/jandrol.107.004119
   Vaidya VS, 2010, NAT BIOTECHNOL, V28, P478, DOI 10.1038/nbt.1623
   Van Guilder GP, 2006, OBESITY, V14, P2127, DOI 10.1038/oby.2006.248
   Weltoft GR, 2004, SOC SCI MED, V59, P1449, DOI 10.1016/j.socscimed.2004.01.026
   Williams DH, 2009, J UROLOGY, V181, P736, DOI 10.1016/j.juro.2008.10.023
   Wogatzky J, 2012, REPROD BIOL ENDOCRIN, V10, DOI 10.1186/1477-7827-10-115
   World Health Organization, 2004, DIAB ACT NOW, P20
   Wyrobek AJ, 2006, P NATL ACAD SCI USA, V103, P9601, DOI 10.1073/pnas.0506468103
   Yao DC, 2010, DIABETES, V59, P249, DOI 10.2337/db09-0801
   Zhao GQ, 2002, DEV CELL, V2, P537, DOI 10.1016/S1534-5807(02)00173-9
   Zirkin BR, 1998, SEMIN CELL DEV BIOL, V9, P417, DOI 10.1006/scdb.1998.0253
NR 153
TC 42
Z9 45
U1 0
U2 16
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1011-7571
EI 1423-0151
J9 MED PRIN PRACT
JI Med. Princ. Pract.
PY 2013
VL 22
SU 1
BP 30
EP 42
DI 10.1159/000354208
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 280UZ
UT WOS:000329057600005
PM 24051979
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sud, N
   Taher, J
   Su, QZ
AF Sud, Neetu
   Taher, Jennifer
   Su, Qiaozhu
TI MicroRNAs and Noncoding RNAs in Hepatic Lipid and Lipoprotein
   Metabolism: Potential Therapeutic Targets of Metabolic Disorders
SO DRUG DEVELOPMENT RESEARCH
LA English
DT Review
DE noncoding RNAs; microRNAs; dyslipidemia; metabolic syndrome;
   drug-development
ID REVERSE CHOLESTEROL TRANSPORT; ENDOPLASMIC-RETICULUM STRESS;
   X-RECEPTOR-ALPHA; LXR-ALPHA; BINDING; EXPRESSION; PROTEIN; MIR-33; GENE;
   MITOCHONDRIAL
AB Noncoding RNAs and microRNAs (miRNAs) represent an important class of regulatory molecules that modulate gene expression. The role of miRNAs in diverse cellular processes such as cancer, apoptosis, cell differentiation, cardiac remodeling, and inflammation has been intensively explored. Recent studies further demonstrated the important roles of miRNAs and noncoding RNAs in modulating a broad spectrum of genes involved in lipid synthesis and metabolic pathways. This overview focuses on the role of miRNAs in hepatic lipid and lipoprotein metabolism and their potential as therapeutic targets for metabolic syndrome. This includes recent advances made in the understanding of their target pathways and the clinical development of miRNAs in lipid metabolic disorders. Drug Dev Res 76 : 318-327, 2015. (c) 2015 Wiley Periodicals, Inc.
C1 [Sud, Neetu; Su, Qiaozhu] Univ Nebraska, Dept Nutr & Hlth Sci, Lincoln, NE 68583 USA.
   [Taher, Jennifer] Hosp Sick Children, Res Inst, Program Mol Struct & Funct, Toronto, ON M5G 1X8, Canada.
   [Taher, Jennifer] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada.
C3 University of Nebraska System; University of Nebraska Lincoln;
   University of Toronto; Hospital for Sick Children (SickKids); University
   of Toronto
RP Su, QZ (corresponding author), Univ Nebraska, 316F Leverton Hall, Lincoln, NE 68583 USA.
EM qsu2@unl.edu
RI Taher, Jennifer/GLV-4629-2022
OI Taher, Jennifer/0000-0001-9377-968X; Su, Qiaozhu/0000-0001-8434-1408
FU NIH [P20 GM104320-01A1]; Hatch funds from USDA/NIFA; Doctoral NSERC
   scholarship
FX This work was supported by a P20 GM104320-01A1 grant award from NIH, and
   Hatch funds from USDA/NIFA to Q.S. J.T. is supported by a Doctoral NSERC
   scholarship.
CR Adlakha YK, 2013, CELL DEATH DIS, V4, DOI 10.1038/cddis.2013.46
   Bartel DP, 2004, CELL, V116, P281, DOI 10.1016/S0092-8674(04)00045-5
   Bernstein E, 2001, NATURE, V409, P363, DOI 10.1038/35053110
   Bohnsack MT, 2004, RNA, V10, P185, DOI 10.1261/rna.5167604
   Brookheart RT, 2009, J BIOL CHEM, V284, P7446, DOI 10.1074/jbc.M806209200
   Brown MS, 1997, CELL, V89, P331, DOI 10.1016/S0092-8674(00)80213-5
   Christian P, 2014, AM J PHYSIOL-ENDOC M, V307, pE729, DOI 10.1152/ajpendo.00194.2014
   Chung S, 2011, CIRCULATION, V124, P1663, DOI 10.1161/CIRCULATIONAHA.111.025445
   Cui M, 2015, CANCER RES, V75, P846, DOI 10.1158/0008-5472.CAN-14-1192
   Cui M, 2014, BIOCHEM BIOPH RES CO, V445, P651, DOI 10.1016/j.bbrc.2014.02.068
   Cui M, 2014, BIOCHEM BIOPH RES CO, V444, P270, DOI 10.1016/j.bbrc.2014.01.051
   Dávalos A, 2011, P NATL ACAD SCI USA, V108, P9232, DOI 10.1073/pnas.1102281108
   Delay C, 2011, MOL NEURODEGENER, V6, DOI 10.1186/1750-1326-6-70
   Derrien T, 2012, GENOME RES, V22, P1775, DOI 10.1101/gr.132159.111
   Donner A., 2013, SCIBX, V6, P47
   el Azzouzi H, 2013, CELL METAB, V18, P341, DOI 10.1016/j.cmet.2013.08.009
   Esau C, 2006, CELL METAB, V3, P87, DOI 10.1016/j.cmet.2006.01.005
   Gao W, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-55
   Gerin I, 2010, J BIOL CHEM, V285, P33652, DOI 10.1074/jbc.M110.152090
   Ghosh S, 2012, CURR OPIN ENDOCRINOL, V19, P136, DOI 10.1097/MED.0b013e3283507836
   Goedeke L, 2014, EMBO MOL MED, V6, P1133, DOI 10.15252/emmm.201404046
   Guo Y, 2007, TOXICOL SCI, V96, P294, DOI 10.1093/toxsci/kfm009
   Guttman M, 2012, NATURE, V482, P339, DOI 10.1038/nature10887
   Horie T, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3883
   Hsu SH, 2012, J CLIN INVEST, V122, P2871, DOI 10.1172/JCI63539
   Hussain MM, 2003, J LIPID RES, V44, P22, DOI 10.1194/jlr.R200014-JLR200
   Iliopoulos D, 2010, J LIPID RES, V51, P1513, DOI 10.1194/jlr.M004812
   Kang MH, 2013, ARTERIOSCL THROM VAS, V33, P2724, DOI 10.1161/ATVBAHA.113.302004
   Kida K, 2011, PHARM RES-DORDR, V28, P2467, DOI 10.1007/s11095-011-0473-y
   Kim J, 2012, EXP NEUROL, V235, P476, DOI 10.1016/j.expneurol.2011.11.010
   LEE RC, 1993, CELL, V75, P843, DOI 10.1016/0092-8674(93)90529-Y
   Lee Y, 2003, NATURE, V425, P415, DOI 10.1038/nature01957
   Li B, 2014, J MOL ENDOCRINOL, V53, P393, DOI 10.1530/JME-14-0127
   Li P, 2015, CELL METAB, V21, P455, DOI 10.1016/j.cmet.2015.02.004
   Lin J, 2005, CHEM PHYS LIPIDS, V136, P95
   Lindholm MW, 2012, MOL THER, V20, P376, DOI 10.1038/mt.2011.260
   Loebel DAF, 2005, GENOMICS, V85, P782, DOI 10.1016/j.ygeno.2005.02.001
   Lv YC, 2015, ATHEROSCLEROSIS, V240, P80, DOI 10.1016/j.atherosclerosis.2015.02.044
   Magistri M, 2012, TRENDS GENET, V28, P389, DOI 10.1016/j.tig.2012.03.013
   Mak PA, 2002, J BIOL CHEM, V277, P31900, DOI 10.1074/jbc.M202993200
   Mannaerts GP, 2000, CELL BIOCHEM BIOPHYS, V32, P73, DOI 10.1385/CBB:32:1-3:73
   Marquart TJ, 2010, P NATL ACAD SCI USA, V107, P12228, DOI 10.1073/pnas.1005191107
   Maxwell KN, 2004, P NATL ACAD SCI USA, V101, P7100, DOI 10.1073/pnas.0402133101
   Mazar J, 2014, ONCOTARGET, V5, P8959, DOI 10.18632/oncotarget.1863
   Miller AM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0072324
   Moretti F, 2010, RNA, V16, P2493, DOI 10.1261/rna.2384610
   Mulvihill EE, 2012, PPAR RES, V2012, DOI 10.1155/2012/857142
   Najafi-Shoushtari SH, 2010, SCIENCE, V328, P1566, DOI 10.1126/science.1189123
   Ng R, 2014, HEPATOLOGY, V60, P554, DOI 10.1002/hep.27153
   Pagidipati NJ, 2013, CIRCULATION, V127, P749, DOI 10.1161/CIRCULATIONAHA.112.128413
   Rackham O, 2011, RNA, V17, P2085, DOI 10.1261/rna.029405.111
   Ramírez CM, 2013, CIRC RES, V112, P1592, DOI 10.1161/CIRCRESAHA.112.300626
   Ramirez CM, 2011, ARTERIOSCL THROM VAS, V31, P2707, DOI 10.1161/ATVBAHA.111.232066
   Rayner KJ, 2011, NATURE, V478, P404, DOI 10.1038/nature10486
   Rayner KJ, 2011, J CLIN INVEST, V121, P2921, DOI 10.1172/JCI57275
   Rayner KJ, 2010, SCIENCE, V328, P1570, DOI 10.1126/science.1189862
   Repa JJ, 2000, GENE DEV, V14, P2819, DOI 10.1101/gad.844900
   Repa JJ, 2002, J BIOL CHEM, V277, P18793, DOI 10.1074/jbc.M109927200
   Rinn JL, 2012, ANNU REV BIOCHEM, V81, P145, DOI 10.1146/annurev-biochem-051410-092902
   SCHOONJANS K, 1995, J BIOL CHEM, V270, P19269, DOI 10.1074/jbc.270.33.19269
   Shimano H, 2001, PROG LIPID RES, V40, P439, DOI 10.1016/S0163-7827(01)00010-8
   Soh J, 2013, NAT MED, V19, P892, DOI 10.1038/nm.3200
   Su QZ, 2014, AM J PHYSIOL-ENDOC M, V306, pE1264, DOI 10.1152/ajpendo.00438.2013
   Su QZ, 2010, CLIN LIPIDOL, V5, P267, DOI 10.2217/CLP.10.15
   Su QZ, 2009, HEPATOLOGY, V50, P77, DOI 10.1002/hep.22960
   Sun DS, 2012, FEBS LETT, V586, P1472, DOI 10.1016/j.febslet.2012.03.068
   van Heesch S, 2014, GENOME BIOL, V15, DOI 10.1186/gb-2014-15-1-r6
   van Rooij E, 2007, SCIENCE, V316, P575, DOI 10.1126/science.1139089
   Vickers KC, 2014, P NATL ACAD SCI USA, V111, P14518, DOI 10.1073/pnas.1215767111
   Wang L, 2013, MOL CELL BIOL, V33, P1956, DOI 10.1128/MCB.01580-12
   Yang T, 2002, CELL, V110, P489, DOI 10.1016/S0092-8674(02)00872-3
   Yu RZ, 2009, BIOCHEM PHARMACOL, V77, P910, DOI 10.1016/j.bcp.2008.11.005
   Zhang B, 2014, MOL CELL BIOL, V34, P2318, DOI 10.1128/MCB.01673-13
   Zhang M, 2014, ATHEROSCLEROSIS, V234, P54, DOI 10.1016/j.atherosclerosis.2014.02.008
   Zhao RZ, 2014, BIOCHEM BIOPH RES CO, V448, P329, DOI 10.1016/j.bbrc.2014.04.052
NR 75
TC 21
Z9 24
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0272-4391
EI 1098-2299
J9 DRUG DEVELOP RES
JI Drug Dev. Res.
PD SEP
PY 2015
VL 76
IS 6
SI SI
BP 318
EP 327
DI 10.1002/ddr.21269
PG 10
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CR2UG
UT WOS:000361185500007
PM 26286650
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Dorresteijn, JAN
   Visseren, FLJ
   Spiering, W
AF Dorresteijn, J. A. N.
   Visseren, F. L. J.
   Spiering, W.
TI Mechanisms linking obesity to hypertension
SO OBESITY REVIEWS
LA English
DT Article
DE Hypertension; metabolic syndrome; obesity; obesity-related hypertension
ID SYMPATHETIC-NERVE ACTIVITY; CARDIOVASCULAR RISK-FACTORS; BODY-MASS
   INDEX; CANNABINOID-1 RECEPTOR BLOCKER; ADIPOSE-TISSUE MASS; C-REACTIVE
   PROTEIN; BLOOD-PRESSURE; WEIGHT-LOSS; RESISTANT HYPERTENSION; METABOLIC
   SYNDROME
AB Obesity-related hypertension is increasingly recognized as a distinct hypertensive phenotype requiring a modified approach to diagnosis and management. In this review rapidly evolving insights into the complex and interdependent mechanisms linking obesity to hypertension are discussed. Overweight and obesity are associated with adipose tissue dysfunction, characterized by enlarged hypertrophied adipocytes, increased infiltration by macrophages and marked changes in secretion of adipokines and free fatty acids. This results in chronic vascular inflammation, oxidative stress, activation of the renin-angiotensin-aldosterone system and sympathetic overdrive, eventually leading to hypertension. These mechanisms may provide novel targets for anti-hypertensive drug treatment. Recognition of obesity-related hypertension as a distinct diagnosis enables tailored therapy in clinical practice. This includes lifestyle modification and accommodated choice of blood pressure-lowering drugs.
C1 [Dorresteijn, J. A. N.; Visseren, F. L. J.; Spiering, W.] Univ Med Ctr Utrecht, Dept Vasc Med, NL-3584 CX Utrecht, Netherlands.
C3 Utrecht University; Utrecht University Medical Center
RP Spiering, W (corresponding author), Univ Med Ctr Utrecht, Dept Vasc Med, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands.
EM w.spiering@umcutrecht.nl
RI Visseren, Frank/I-4855-2013
OI Spiering, Wilko/0000-0002-2493-6407; Visseren, Frank/0000-0003-3951-5223
CR [Anonymous], 2004, COCHRANE DB SYST REV
   Ashley EA, 2005, CARDIOVASC RES, V65, P73, DOI 10.1016/j.cardiores.2004.08.018
   Azuma K, 2003, OBES RES, V11, P997, DOI 10.1038/oby.2003.137
   Bentley-Lewis R, 2007, J CLIN ENDOCR METAB, V92, P4472, DOI 10.1210/jc.2007-1088
   Biaggioni I, 2008, HYPERTENSION, V51, P168, DOI 10.1161/HYPERTENSIONAHA.107.090514
   Brown CD, 2000, OBES RES, V8, P605, DOI 10.1038/oby.2000.79
   Calhoun DA, 2008, CIRCULATION, V117, pE510, DOI 10.1161/CIRCULATIONAHA.108.189141
   Cancello R, 2006, DIABETES, V55, P1554, DOI 10.2337/db06-0133
   Cao Y, 2009, J MOL CELL CARDIOL, V46, P413, DOI 10.1016/j.yjmcc.2008.10.014
   Cassano Patricia A., 1990, Annals of Epidemiology, V1, P33
   Chae CU, 2001, HYPERTENSION, V38, P399, DOI 10.1161/01.HYP.38.3.399
   Chen CY, 2010, AM J PHYSIOL-HEART C, V299, pH193, DOI 10.1152/ajpheart.00431.2009
   Chen J, 2009, LANCET, V373, P829, DOI 10.1016/S0140-6736(09)60144-6
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   Coliussi G, 2007, DIABETES CARE, V30, P2349, DOI 10.2337/dc07-0525
   Considine RV, 1996, NEW ENGL J MED, V334, P292, DOI 10.1056/NEJM199602013340503
   da Silva AA, 2008, HYPERTENSION, V51, P884, DOI 10.1161/HYPERTENSIONAHA.107.100636
   Dall'Asta C, 2009, NUTR METAB CARDIOVAS, V19, P110, DOI 10.1016/j.numecd.2008.06.001
   De Marco M, 2009, HYPERTENSION, V54, P974, DOI 10.1161/HYPERTENSIONAHA.109.129031
   de Paula RB, 2004, HYPERTENSION, V43, P41, DOI 10.1161/01.HYP.0000105624.68174.00
   Droyvold WB, 2005, INT J OBESITY, V29, P650, DOI 10.1038/sj.ijo.0802944
   Ehrhart-Bornstein M, 2003, P NATL ACAD SCI USA, V100, P14211, DOI 10.1073/pnas.2336140100
   Engeli S, 2005, HYPERTENSION, V45, P356, DOI 10.1161/01.HYP.0000154361.47683.d3
   Esler MD, 2010, LANCET, V376, P1903, DOI 10.1016/S0140-6736(10)62039-9
   Faber DR, 2010, ATHEROSCLEROSIS, V212, P274, DOI 10.1016/j.atherosclerosis.2010.04.029
   Flegal KM, 2010, JAMA-J AM MED ASSOC, V303, P235, DOI 10.1001/jama.2009.2014
   Fontana L, 2007, DIABETES, V56, P1010, DOI 10.2337/db06-1656
   FREDERICH RC, 1992, HYPERTENSION, V19, P339, DOI 10.1161/01.HYP.19.4.339
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   GARRISON RJ, 1987, PREV MED, V16, P235, DOI 10.1016/0091-7435(87)90087-9
   Gletsu-Miller N, 2009, OBESITY, V17, P439, DOI 10.1038/oby.2008.542
   Goodfriend TL, 2004, HYPERTENSION, V43, P358, DOI 10.1161/01.HYP.0000113294.06704.64
   Goodfriend TL, 1999, OBES RES, V7, P355, DOI 10.1002/j.1550-8528.1999.tb00418.x
   Grassi G, 2004, J HYPERTENS, V22, P2363, DOI 10.1097/00004872-200412000-00019
   GRASSI G, 1995, HYPERTENSION, V25, P560, DOI 10.1161/01.HYP.25.4.560
   Grassi G, 2003, J HYPERTENS, V21, P1761, DOI 10.1097/00004872-200309000-00027
   Greenfield JR, 2009, NEW ENGL J MED, V360, P44, DOI 10.1056/NEJMoa0803085
   Hajer GR, 2008, EUR HEART J, V29, P2959, DOI 10.1093/eurheartj/ehn387
   Harlan SM, 2011, CIRC RES, V108, P808, DOI 10.1161/CIRCRESAHA.111.240226
   Heinonen MV, 2005, REGUL PEPTIDES, V130, P7, DOI 10.1016/j.regpep.2005.05.003
   Higuchi K, 2007, ENDOCRINOLOGY, V148, P2690, DOI 10.1210/en.2006-1270
   Hoyda TD, 2009, BRAIN RES, V1256, P76, DOI 10.1016/j.brainres.2008.12.012
   Huggett RJ, 2004, HYPERTENSION, V44, P847, DOI 10.1161/01.HYP.0000147893.08533.d8
   Ingelsson E, 2007, CIRCULATION, V116, P984, DOI 10.1161/CIRCULATIONAHA.107.708537
   Jansen PM, 2010, CURR HYPERTENS REP, V12, P220, DOI 10.1007/s11906-010-0123-5
   Johansson ME, 2008, AM J PHYSIOL-REG I, V294, pR1240, DOI 10.1152/ajpregu.00493.2007
   Jordan J, 2007, HYPERTENSION, V49, P1047, DOI 10.1161/HYPERTENSIONAHA.106.084301
   KASSAB S, 1995, HYPERTENSION, V25, P893, DOI 10.1161/01.HYP.25.4.893
   Kawanami D, 2004, BIOCHEM BIOPH RES CO, V314, P415, DOI 10.1016/j.bbrc.2003.12.104
   Kim F, 2005, ARTERIOSCL THROM VAS, V25, P989, DOI 10.1161/01.ATV.0000160549.60980.a8
   Kos K, 2007, J CLIN ENDOCR METAB, V92, P1129, DOI 10.1210/jc.2006-1841
   Kotchen TA, 2010, AM J HYPERTENS, V23, P1170, DOI 10.1038/ajh.2010.172
   Kraschnewski JL, 2010, INT J OBESITY, V34, P1644, DOI 10.1038/ijo.2010.94
   Lee CMY, 2008, J CLIN EPIDEMIOL, V61, P646, DOI 10.1016/j.jclinepi.2007.08.012
   Lin YZ, 2004, HYPERTENSION, V43, P977, DOI 10.1161/01.HYP.0000122803.91559.55
   Liu JK, 2006, J HYPERTENS, V24, P1391, DOI 10.1097/01.hjh.0000234120.71142.6c
   Lohmeier TE, 2000, AM J PHYSIOL-REG I, V279, pR1437, DOI 10.1152/ajpregu.2000.279.4.R1437
   Lohmeier TE, 2011, HYPERTENSION, V57, P880, DOI 10.1161/HYPERTENSIONAHA.108.119859
   Mancia G, 2007, EUR HEART J, V28, P1462, DOI 10.1093/eurheartj/ehm236
   Massiéra F, 2001, FASEB J, V15, P2727, DOI 10.1096/fj.01-0457fje
   Matsuda M, 2002, J BIOL CHEM, V277, P37487, DOI 10.1074/jbc.M206083200
   MATSUKAWA T, 1991, AM J PHYSIOL, V261, pR690, DOI 10.1152/ajpregu.1991.261.3.R690
   Matsumura K, 2003, REGUL PEPTIDES, V114, P79, DOI 10.1016/S0167-0115(03)00116-2
   Muntzel Martin S., 1994, American Journal of Physiology, V267, pR1350
   Myers MG, 2008, ANNU REV PHYSIOL, V70, P537, DOI 10.1146/annurev.physiol.70.113006.100707
   Narkiewicz K, 2006, OBES REV, V7, P155, DOI 10.1111/j.1467-789X.2006.00226.x
   Neter JE, 2003, HYPERTENSION, V42, P878, DOI 10.1161/01.HYP.0000094221.86888.AE
   Nguyen NT, 2008, J AM COLL SURGEONS, V207, P928, DOI 10.1016/j.jamcollsurg.2008.08.022
   Okada S, 2010, METABOLISM, V59, P1241, DOI 10.1016/j.metabol.2009.11.016
   Ouchi N, 2003, HYPERTENSION, V42, P231, DOI 10.1161/01.HYP.0000083488.67550.B8
   Ouchi N, 2000, CIRCULATION, V102, P1296, DOI 10.1161/01.CIR.102.11.1296
   Ouedraogo R, 2007, J CLIN INVEST, V117, P1718, DOI 10.1172/JCI29623
   PETRASEK D, 1992, LIFE SCI, V50, P1781, DOI 10.1016/0024-3205(92)90062-T
   Phillips SA, 2010, CURR OPIN PHARMACOL, V10, P676, DOI 10.1016/j.coph.2010.08.002
   Pi-Sunyer F, 2006, JAMA-J AM MED ASSOC, V295, P761, DOI 10.1001/jama.295.7.761
   Pimenta E, 2009, HYPERTENSION, V54, P475, DOI 10.1161/HYPERTENSIONAHA.109.131235
   Pou KM, 2007, CIRCULATION, V116, P1234, DOI 10.1161/CIRCULATIONAHA.107.710509
   Rahmouni K, 2005, DIABETES, V54, P2012, DOI 10.2337/diabetes.54.7.2012
   Ridker PM, 2000, NEW ENGL J MED, V342, P836, DOI 10.1056/NEJM200003233421202
   Rumantir MS, 1999, J HYPERTENS, V17, P1125, DOI 10.1097/00004872-199917080-00012
   SAAD MF, 1990, DIABETES, V39, P1430, DOI 10.2337/diabetes.39.11.1430
   Salki A, 2009, METABOLISM, V58, P708, DOI 10.1016/j.metabol.2009.01.013
   Sanjuliani AF, 2006, INT J CLIN PRACT, V60, P621, DOI 10.1111/j.1368-5031.2006.00951.x
   Savage DB, 2001, DIABETES, V50, P2199, DOI 10.2337/diabetes.50.10.2199
   Scherrer U, 1996, NEW ENGL J MED, V335, P1240, DOI 10.1056/NEJM199610173351617
   Schmieder RE, 2009, J HYPERTENS, V27, P1493, DOI 10.1097/HJH.0b013e32832be593
   Schnabel R, 2008, HYPERTENSION, V51, P1651, DOI 10.1161/HYPERTENSIONAHA.107.105668
   Scholze J, 2007, CIRCULATION, V115, P1991, DOI 10.1161/CIRCULATIONAHA.106.625400
   Sjöström L, 2004, NEW ENGL J MED, V351, P2683, DOI 10.1056/NEJMoa035622
   Sprague AH, 2009, BIOCHEM PHARMACOL, V78, P539, DOI 10.1016/j.bcp.2009.04.029
   Steinberg HO, 2000, DIABETES, V49, P1231, DOI 10.2337/diabetes.49.7.1231
   Straznicky NE, 2005, J CLIN ENDOCR METAB, V90, P5998, DOI 10.1210/jc.2005-0961
   Tan KCB, 2004, J CLIN ENDOCR METAB, V89, P765, DOI 10.1210/jc.2003-031012
   Tanida M, 2007, EXP BIOL MED, V232, P390
   Tank J, 2008, J CLIN ENDOCR METAB, V93, P4974, DOI 10.1210/jc.2007-2820
   Thatcher S, 2009, MOL CELL ENDOCRINOL, V302, P111, DOI 10.1016/j.mce.2009.01.019
   Timpson NJ, 2009, HYPERTENSION, V54, P84, DOI 10.1161/HYPERTENSIONAHA.109.130005
   Tomiyama H, 2009, AM J HYPERTENS, V22, P630, DOI 10.1038/ajh.2009.49
   Torgerson JS, 2004, DIABETES CARE, V27, P155, DOI 10.2337/diacare.27.1.155
   Umemura S, 1997, AM J HYPERTENS, V10, P629, DOI 10.1016/S0895-7061(97)00053-8
   Van Gaal LF, 2005, LANCET, V365, P1389, DOI 10.1016/S0140-6736(05)66374-X
   Vasan RS, 2001, LANCET, V358, P1682, DOI 10.1016/S0140-6736(01)06710-1
   Verma S, 2003, CIRCULATION, V108, P736, DOI 10.1161/01.CIR.0000084503.91330.49
   Verma S, 2001, AM J HYPERTENS, V14, P429, DOI 10.1016/S0895-7061(00)01261-9
   Vlasova M, 2010, ACTA PHYSIOL, V200, P107, DOI 10.1111/j.1748-1716.2010.02171.x
   Wada T, 2009, ENDOCRINOLOGY, V150, P1662, DOI 10.1210/en.2008-1018
   Wang ZV, 2008, HYPERTENSION, V51, P8, DOI 10.1161/HYPERTENSIONAHA.107.099424
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Weiss R, 2004, NEW ENGL J MED, V350, P2362, DOI 10.1056/NEJMoa031049
   Weyer C, 2000, HYPERTENSION, V36, P531, DOI 10.1161/01.HYP.36.4.531
   Yasue S, 2010, AM J HYPERTENS, V23, P425, DOI 10.1038/ajh.2009.263
   Yoshimoto M, 2010, HYPERTENSION, V55, P644, DOI 10.1161/HYPERTENSIONAHA.109.145110
   Zhang Q, 2009, CIRC RES, V104, P1421, DOI 10.1161/CIRCRESAHA.108.192302
NR 113
TC 150
Z9 172
U1 0
U2 57
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD JAN
PY 2012
VL 13
IS 1
BP 17
EP 26
DI 10.1111/j.1467-789X.2011.00914.x
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 862LN
UT WOS:000298092500003
PM 21831233
DA 2025-06-11
ER

PT J
AU Murri, MB
   Pariante, C
   Mondelli, V
   Masotti, M
   Atti, AR
   Mellacqua, Z
   Antonioli, M
   Ghio, L
   Menchetti, M
   Zanetidou, S
   Innamorati, M
   Amore, M
AF Murri, Martino Belvederi
   Pariante, Carmine
   Mondelli, Valeria
   Masotti, Mattia
   Atti, Anna Rita
   Mellacqua, Zefiro
   Antonioli, Marco
   Ghio, Lucio
   Menchetti, Marco
   Zanetidou, Stamatula
   Innamorati, Marco
   Amore, Mario
TI HPA axis and aging in depression: Systematic review and meta-analysis
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE Cortisol; ACTH; CRH; Depression; Depressive symptoms; Elderly; Older
   adults; HPA axis; Dexamethasone; Antidepressant
ID DEXAMETHASONE-SUPPRESSION TEST; PITUITARY-ADRENAL AXIS; LATE-LIFE
   DEPRESSION; SALIVARY CORTISOL; MAJOR DEPRESSION; HYPERCORTISOLEMIC
   DEPRESSION; PSYCHOGERIATRIC POPULATION; GERIATRIC DEPRESSION;
   ALZHEIMERS-DISEASE; METABOLIC SYNDROME
AB One of the most consistent findings in the biology of depression is an altered activity of the hypothalamic pituitary adrenal (HPA) axis. However, data concerning this issue have never been examined with a focus on the older population. Here we present a systematic review and meta-analysis, based on studies investigating levels of cortisol, adrenocorticotropic hormone (ACTH) and corticotropin-releasing hormone (CRH) in depressed participants older than 60 and compared with healthy controls. We found 20 studies, for a total of 43 comparisons on different indices of HPA axis functioning. Depression had a significant effect (Hedges' g) on basal cortisol levels measured in the morning (0.89), afternoon (0.83) and night (1.39), but a smaller effect on cortisol measured continuously (0.51). The effect of depression was even higher on postdexamethasone cortisol levels (3.22), whereas it was non-significant on morning ACTH and CRH levels. Subgroup analyses indicated that various methodological and clinical factors can influence the study results. Overall, older participants suffering from depression show a high degree of dysregulation of HPA axis activity, with differences compared with younger adults. This might depend on several mechanisms, including physical illnesses, alterations in the CNS and immune-endocrinological alterations. Further studies are needed to clarify the implications of altered HPA axis activity in older patients suffering from depression. Novel pharmacological approaches might be effective in targeting this pathophysiological feature, thus improving the clinical outcomes. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Murri, Martino Belvederi; Pariante, Carmine; Mondelli, Valeria] Kings Coll London, Dept Psychol Med, Inst Psychiat, London SE5 9NU, England.
   [Murri, Martino Belvederi; Innamorati, Marco] Univ Parma, Div Psychiat, Dept Neurosci, I-43100 Parma, Italy.
   [Masotti, Mattia; Ghio, Lucio; Amore, Mario] Univ Genoa, Dept Neurosci Oftalmol Genet & Infant Maternal Sc, Sect Psychiat, Genoa, Italy.
   [Atti, Anna Rita; Antonioli, Marco] Univ Bologna, Dept Biomed & NeuroMotor Sci Psychiat, I-40126 Bologna, Italy.
   [Mellacqua, Zefiro] Kings Coll London, Dept Psychosis Studies, Inst Psychiat, London SE5 9NU, England.
   [Menchetti, Marco] Univ Bologna, Dept Med & Surg Sci, Sect Psychiat, I-40126 Bologna, Italy.
   [Zanetidou, Stamatula] AUSL Bologna, Dept Mental Hlth, Bologna, Italy.
C3 University of London; King's College London; University of Parma;
   University of Genoa; University of Bologna; University of London; King's
   College London; University of Bologna; AUSL di Bologna
RP Murri, MB (corresponding author), Kings Coll London, James Black Ctr, Dept Psychol Med, Sect Perinatal Psychiat & Stress,Inst Psychiat, Room 2-055,125 Coldharbour Lane, London SE5 9NU, England.
EM martino.belvederi@gmail.com
RI Mondelli, Valeria/K-8988-2016; Atti, Anna/AAP-7878-2020; Altamura,
   Mario/IQS-2773-2023; Innamorati, Marco/H-8877-2013; Pariante, Carmine
   Maria/B-1297-2011; Belvederi Murri, Martino/G-8781-2011
OI Mondelli, Valeria/0000-0001-8690-6839; Innamorati,
   Marco/0000-0003-1389-2290; Pariante, Carmine Maria/0000-0002-9132-5091;
   Belvederi Murri, Martino/0000-0002-7262-3528
FU Medical Research Council [G108/603] Funding Source: Medline; MRC
   [G108/603] Funding Source: UKRI
CR Adler G, 2001, NEUROSCI LETT, V298, P142, DOI 10.1016/S0304-3940(00)01754-7
   Alexapoulos GS, 2005, LANCET, V365, P1961, DOI 10.1016/S0140-6736(05)66665-2
   Alexopoulos GS, 2011, INT J GERIATR PSYCH, V26, P1109, DOI 10.1002/gps.2672
   Anacker C, 2011, PSYCHONEUROENDOCRINO, V36, P415, DOI 10.1016/j.psyneuen.2010.03.007
   Balardin JB, 2011, J GERIATR PSYCH NEUR, V24, P19, DOI 10.1177/0891988710373599
   BARTOLONI C, 1991, MECH AGEING DEV, V60, P1, DOI 10.1016/0047-6374(91)90104-8
   Beluche I, 2010, PSYCHOL MED, V40, P1039, DOI 10.1017/S0033291709991103
   Beluche I, 2009, J PSYCHIATR RES, V43, P777, DOI 10.1016/j.jpsychires.2008.10.011
   Berardelli R, 2013, ENDOCRINE, V43, P51, DOI 10.1007/s12020-012-9750-8
   Blanco C, 2012, J CLIN PSYCHIAT, V73, P224, DOI 10.4088/JCP.10m06227
   Bosker FJ, 2004, CNS DRUGS, V18, P705, DOI 10.2165/00023210-200418110-00002
   Bremmer MA, 2007, BIOL PSYCHIAT, V62, P479, DOI 10.1016/j.biopsych.2006.11.033
   Brown ES, 2004, BIOL PSYCHIAT, V55, P1, DOI 10.1016/S0006-3223(03)00473-6
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   Byers AL, 2011, NAT REV NEUROL, V7, P323, DOI 10.1038/nrneurol.2011.60
   Carroll BJ, 2012, ACTA PSYCHIAT SCAND, V125, P478, DOI 10.1111/j.1600-0447.2011.01821.x
   Champaneri S, 2012, METABOLISM, V61, P986, DOI 10.1016/j.metabol.2011.11.006
   Chiodini I, 2007, ANN INTERN MED, V147, P541, DOI 10.7326/0003-4819-147-8-200710160-00006
   Comijs HC, 2010, AM J GERIAT PSYCHIAT, V18, P42, DOI 10.1097/JGP.0b013e3181b970ae
   Contreras F, 2007, J AFFECT DISORDERS, V100, P65, DOI 10.1016/j.jad.2006.09.021
   Dedovic K, 2009, NEUROIMAGE, V47, P864, DOI 10.1016/j.neuroimage.2009.05.074
   DELEO D, 1988, EUR ARCH PSY CLIN N, V238, P19
   Deuschle M, 1997, LIFE SCI, V61, P2239, DOI 10.1016/S0024-3205(97)00926-0
   Fabian TJ, 2001, BIOL PSYCHIAT, V50, P767, DOI 10.1016/S0006-3223(01)01198-2
   Ferrari E, 2001, BRAIN RES REV, V37, P294, DOI 10.1016/S0165-0173(01)00133-3
   FERRIER IN, 1988, BIOL PSYCHIAT, V23, P252
   Franz CE, 2011, PSYCHONEUROENDOCRINO, V36, P1040, DOI 10.1016/j.psyneuen.2011.01.002
   Gardner MP, 2013, PSYCHONEUROENDOCRINO, V38, P40, DOI 10.1016/j.psyneuen.2012.04.016
   GEORGOTAS A, 1986, J AFFECT DISORDERS, V10, P51, DOI 10.1016/0165-0327(86)90048-0
   Golden SH, 2007, J CLIN ENDOCR METAB, V92, P1358, DOI 10.1210/jc.2006-2674
   GOTTHARDT U, 1995, AM J PHYSIOL-REG I, V268, pR865, DOI 10.1152/ajpregu.1995.268.4.R865
   Heaney JLJ, 2010, INT J PSYCHOPHYSIOL, V78, P201, DOI 10.1016/j.ijpsycho.2010.07.009
   Hegeman JM, 2012, BRIT J PSYCHIAT, V200, P275, DOI 10.1192/bjp.bp.111.095950
   Hellhammer DH, 2009, PSYCHONEUROENDOCRINO, V34, P163, DOI 10.1016/j.psyneuen.2008.10.026
   Heuser I, 2000, NEUROBIOL AGING, V21, P585, DOI 10.1016/S0197-4580(00)00145-7
   Hinkelmann K, 2012, PSYCHONEUROENDOCRINO, V37, P685, DOI 10.1016/j.psyneuen.2011.08.012
   Holland JM, 2013, PSYCHIAT RES, V210, P444, DOI 10.1016/j.psychres.2013.07.033
   Jokinen J, 2008, PSYCHONEUROENDOCRINO, V33, P1387, DOI 10.1016/j.psyneuen.2008.07.012
   Juruena MF, 2013, J PSYCHOPHARMACOL, V27, P1169, DOI 10.1177/0269881113499205
   Kalsbeek A, 2012, MOL CELL ENDOCRINOL, V349, P20, DOI 10.1016/j.mce.2011.06.042
   Kemp AH, 2010, BIOL PSYCHIAT, V67, P1067, DOI [10.1016/j.biopsych.2009.12.012, 10.1016/j.biopsych.2009.11.019]
   Kin NMKNY, 1997, BIOL PSYCHIAT, V42, P925
   Köhler S, 2010, BRIT J PSYCHIAT, V196, P143, DOI 10.1192/bjp.bp.109.071399
   Kudielka BM, 2012, PSYCHOSOM MED, V74, P418, DOI 10.1097/PSY.0b013e31825434c7
   Kuo SY, 2011, PSYCHOL MED, V41, P1665, DOI 10.1017/S0033291710002473
   Lamers F, 2013, MOL PSYCHIATR, V18, P692, DOI 10.1038/mp.2012.144
   LEAKE A, 1990, BRIT J PSYCHIAT, V156, P676, DOI 10.1192/bjp.156.5.676
   LEAKE A, 1989, CLIN ENDOCRINOL, V30, P39, DOI 10.1111/j.1365-2265.1989.tb03725.x
   Lopez-Duran NL, 2009, PSYCHONEUROENDOCRINO, V34, P1272, DOI 10.1016/j.psyneuen.2009.03.016
   Lupien S, 1996, NEUROBIOL AGING, V17, P95, DOI 10.1016/0197-4580(95)02005-5
   Lupien SJ, 2005, J PSYCHIATR NEUROSCI, V30, P328
   Lupien SJ, 1997, BRAIN RES REV, V24, P1, DOI 10.1016/S0165-0173(97)00004-0
   Maina G, 2012, TOXICOL LETT, V213, P21, DOI 10.1016/j.toxlet.2011.08.019
   Maj M, 2012, PSYCHOPATHOLOGY, V45, P135, DOI 10.1159/000329100
   Maninger N, 2009, FRONT NEUROENDOCRIN, V30, P65, DOI 10.1016/j.yfrne.2008.11.002
   Mantella RC, 2008, PSYCHONEUROENDOCRINO, V33, P773, DOI 10.1016/j.psyneuen.2008.03.002
   Marinho PEM, 2012, ARCH GERONTOL GERIAT, V54, P453, DOI 10.1016/j.archger.2011.05.006
   McAllister-Williams RH, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-205
   MCCLURE DJ, 1966, J PSYCHOSOM RES, V10, P189, DOI 10.1016/0022-3999(66)90062-6
   McKay MS, 2010, J PSYCHIATR RES, V44, P183, DOI 10.1016/j.jpsychires.2009.07.012
   MEYERS BS, 1993, BIOL PSYCHIAT, V34, P108, DOI 10.1016/0006-3223(93)90263-D
   MOLCHAN SE, 1993, PSYCHONEUROENDOCRINO, V18, P509, DOI 10.1016/0306-4530(93)90044-L
   Morimoto SS, 2011, PSYCHIAT CLIN N AM, V34, P437, DOI 10.1016/j.psc.2011.02.006
   MULLER HF, 1974, J GERONTOL, V29, P28, DOI 10.1093/geronj/29.1.28
   Naismith SL, 2012, PROG NEUROBIOL, V98, P99, DOI 10.1016/j.pneurobio.2012.05.009
   O'Brien JT, 2004, AM J PSYCHIAT, V161, P2081, DOI 10.1176/appi.ajp.161.11.2081
   O'Keane V, 2012, PSYCHONEUROENDOCRINO, V37, P1589, DOI 10.1016/j.psyneuen.2012.03.009
   OBrien JT, 1997, INT J GERIATR PSYCH, V12, P211, DOI 10.1002/(SICI)1099-1166(199702)12:2<211::AID-GPS558>3.0.CO;2-K
   OBrien JT, 1996, BRIT J PSYCHIAT, V168, P679, DOI 10.1192/bjp.168.6.679
   Oldehinkel AJ, 2001, PSYCHIAT RES, V104, P39, DOI 10.1016/S0165-1781(01)00300-6
   Otte C, 2005, PSYCHONEUROENDOCRINO, V30, P80, DOI 10.1016/j.psyneuen.2004.06.002
   Otte C, 2004, BIOL PSYCHIAT, V56, P241, DOI 10.1016/j.biopsych.2004.06.003
   Otte C, 2010, J PSYCHIATR RES, V44, P339, DOI 10.1016/j.jpsychires.2009.10.006
   Pariante CM, 2008, TRENDS NEUROSCI, V31, P464, DOI 10.1016/j.tins.2008.06.006
   Pariante CM, 2004, PSYCHOPHARMACOLOGY, V177, P200, DOI 10.1007/s00213-004-1925-4
   Pariante CM, 2001, BIOL PSYCHIAT, V49, P391, DOI 10.1016/S0006-3223(00)01088-X
   Penninx BWJH, 2007, AM J GERIAT PSYCHIAT, V15, P522, DOI 10.1097/JGP.0b013e318033ed80
   PICCIRILLO G, 1994, AM J MED SCI, V307, P228, DOI 10.1097/00000441-199403000-00011
   Pompili M, 2010, EUR ARCH PSY CLIN N, V260, P583, DOI 10.1007/s00406-010-0108-z
   Sagud M, 2002, NEUROPSYCHOBIOLOGY, V45, P139, DOI 10.1159/000054954
   SAPOLSKY RM, 1986, ENDOCR REV, V7, P284, DOI 10.1210/edrv-7-3-284
   Schüle C, 2007, J NEUROENDOCRINOL, V19, P213, DOI 10.1111/j.1365-2826.2006.01516.x
   Sexton CE, 2012, BRIT J PSYCHIAT, V201, P46, DOI 10.1192/bjp.bp.111.105361
   SIEGEL B, 1989, BIOL PSYCHIAT, V25, P229, DOI 10.1016/0006-3223(89)90168-6
   Sindi S, 2012, STRESS, V15, P130, DOI 10.3109/10253890.2011.599047
   Stetler C, 2011, PSYCHOSOM MED, V73, P114, DOI 10.1097/PSY.0b013e31820ad12b
   Tak LM, 2011, BIOL PSYCHOL, V87, P183, DOI 10.1016/j.biopsycho.2011.02.002
   Taylor WD, 2013, MOL PSYCHIATR, V18, P963, DOI 10.1038/mp.2013.20
   Terzidis K, 2011, J ENDOCRINOL INVEST, V34, pE398, DOI 10.3275/7868
   Uher R, 2012, DEPRESS ANXIETY, V29, P1043, DOI 10.1002/da.21993
   Veldhuis JD, 2011, J CLIN ENDOCR METAB, V96, P2874, DOI 10.1210/jc.2011-0084
   Vogelzangs N, 2007, PSYCHONEUROENDOCRINO, V32, P151, DOI 10.1016/j.psyneuen.2006.11.009
   Weber-Hamann B, 2002, PSYCHOSOM MED, V64, P274, DOI 10.1097/00006842-200203000-00010
   WEINER MF, 1993, BIOL PSYCHIAT, V33, P560, DOI 10.1016/0006-3223(93)90015-6
   Wikgren M, 2012, BIOL PSYCHIAT, V71, P294, DOI 10.1016/j.biopsych.2011.09.015
   Young EA, 2004, FRONT NEUROENDOCRIN, V25, P69, DOI 10.1016/j.yfrne.2004.07.001
   Zunszain PA, 2011, PROG NEURO-PSYCHOPH, V35, P722, DOI 10.1016/j.pnpbp.2010.04.011
NR 97
TC 256
Z9 273
U1 0
U2 56
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAR
PY 2014
VL 41
BP 46
EP 62
DI 10.1016/j.psyneuen.2013.12.004
PG 17
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA AB8PR
UT WOS:000332053000005
PM 24495607
DA 2025-06-11
ER

PT J
AU Sangeetha, A
   Bobby, Z
   Wadwekar, V
   Nisha, Y
AF Sangeetha, A.
   Bobby, Zachariah
   Wadwekar, Vaibhav
   Nisha, Yadav
TI Atherogenic Risk Factors among Young Indian Adults with Epilepsy on
   Treatment with Phenytoin: Need for Novel Therapeutic Strategies
SO NEUROLOGY INDIA
LA English
DT Article
DE Dyslipidemia; metabolic syndrome; oxidative stress; phenytoin; systemic
   inflammation
ID SERUM-LIPID PROFILE; OXIDATIVE STRESS; ANTIEPILEPTIC DRUGS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; ANTIOXIDANT; SENSITIVITY;
   HOMEOSTASIS; EXTRACT; RATS
AB Background: Risk for the development of coronary heart disease and diabetes is found to be more among people with epilepsy especially when on treatment. Redox imbalance contributes to this risk especially in India as it is the diabetic capital of the world with higher prevalence of inflammation.
   Objectives: The aim of this study was to evaluate atherogenic risk factors; dyslipidemia, oxidative stress, and systemic inflammation among young Indian adults with epilepsy on treatment with Phenytoin.
   Material and Methods: Three groups of age and gender-matched young subjects were recruited. Group 1-Healthy control subjects, Group 2-Newly diagnosed epileptic young adults with recent epileptic seizures, Group 3-Epileptic adults on treatment with Phenytoin for more than 6 months were recruited.
   Results: Dyslipidemia was found among the newly diagnosed epileptic subjects in comparison to healthy subjects. The LDL-cholesterol further increased, and HDL-cholesterol further decreased in the third group treated with Phenytoin. Body mass index of these treated epileptic subjects was more in comparison to healthy control. Low-grade inflammation as assessed by hsCRP and oxidative stress were significantly higher among the newly diagnosed epileptic subjects when compared to the healthy controls which further increased on treatment with phenytoin. We found dyslipidemia, oxidative stress, and low-grade inflammation among newly diagnosed epileptic subjects which further increased on treatment with Phenytoin for more than 6 months.
   Conclusion: From this study, we conclude that dyslipidemia, oxidative stress and low-grade inflammation are identified among the newly diagnosed young adult Indian epileptic patients. Phenytoin treatment further augmented these complications.
C1 [Sangeetha, A.; Bobby, Zachariah; Nisha, Yadav] Jawaharlal Inst Postgrad Med Educ & Res, Dept Biochem, Pondicherry, India.
   [Wadwekar, Vaibhav] Jawaharlal Inst Postgrad Med Educ & Res, Dept Neurol, Pondicherry, India.
C3 Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research
RP Bobby, Z (corresponding author), JIPMER, Dept Biochem, Pondicherry 605006, India.
EM zacbobby@yahoo.com
RI Zachariah, Bobby/IUQ-0806-2023; Wadwekar, Vaibhav/AAD-4191-2021
FU JIPMER, Puducherry, India
FX This study was carried with the intramural funds received from JIPMER,
   Puducherry-6, India.
CR ALRUBEAAN K, 1991, DIABETIC MED, V8, P968, DOI 10.1111/j.1464-5491.1991.tb01539.x
   Ashwini S, 2015, J FUNCT FOODS, V17, P749, DOI 10.1016/j.jff.2015.06.024
   Benzie IFF, 1996, ANAL BIOCHEM, V239, P70, DOI 10.1006/abio.1996.0292
   CALANDRE EP, 1992, EPILEPSIA, V33, P154, DOI 10.1111/j.1528-1157.1992.tb02299.x
   Chuang YC, 2012, EPILEPSIA, V53, P120, DOI 10.1111/j.1528-1167.2011.03316.x
   Fang JJ, 2012, SEIZURE-EUR J EPILEP, V21, P578, DOI 10.1016/j.seizure.2012.06.001
   Geronzi U, 2018, EXPERT REV NEUROTHER, V18, P427, DOI 10.1080/14737175.2018.1465410
   Hamed SA, 2007, EPILEPSY RES, V75, P1, DOI 10.1016/j.eplepsyres.2007.04.001
   Ishikawa N, 2015, SEIZURE-EUR J EPILEP, V25, P136, DOI 10.1016/j.seizure.2014.10.007
   Keezer MR, 2016, LANCET NEUROL, V15, P106, DOI 10.1016/S1474-4422(15)00225-2
   Koshy SM, 2012, MENOPAUSE, V19, P1146, DOI 10.1097/gme.0b013e31824e5bf7
   Liu CS, 1997, HUM EXP TOXICOL, V16, P177, DOI 10.1177/096032719701600308
   Manimekalai K, 2014, J CLIN DIAGN RES, V8, pHC5, DOI 10.7860/JCDR/2014/8744.4682
   Martinc B, 2014, CURR NEUROPHARMACOL, V12, P527, DOI 10.2174/1570159X12666140923205715
   Menon B, 2012, SEIZURE-EUR J EPILEP, V21, P780, DOI 10.1016/j.seizure.2012.09.003
   MINAKER KL, 1989, ARCH NEUROL-CHICAGO, V46, P981, DOI 10.1001/archneur.1989.00520450051018
   Mintzer S, 2009, ANN NEUROL, V65, P448, DOI 10.1002/ana.21615
   Nair SS, 2016, SEIZURE-EUR J EPILEP, V37, P61, DOI 10.1016/j.seizure.2016.03.002
   Naziroglu M, 2013, CELL MOL NEUROBIOL, V33, P589, DOI 10.1007/s10571-013-9936-5
   Neligan A, 2011, BRAIN, V134, P388, DOI 10.1093/brain/awq378
   Panneerselvam S, 2016, J NUTR BIOCHEM, V38, P57, DOI 10.1016/j.jnutbio.2016.08.007
   Phabphal K, 2012, EUR J NEUROL, V19, P1228, DOI 10.1111/j.1468-1331.2012.03708.x
   Pradeepa R, 2017, EUR J CLIN NUTR, V71, P816, DOI 10.1038/ejcn.2017.40
   Qi Song-Tao, 2001, Di Yi Jun Yi Da Xue Xue Bao, V21, P831
   Reuter S, 2010, FREE RADICAL BIO MED, V49, P1603, DOI 10.1016/j.freeradbiomed.2010.09.006
   SATOH K, 1978, CLIN CHIM ACTA, V90, P37
   Shin EJ, 2011, NEUROCHEM INT, V59, P122, DOI 10.1016/j.neuint.2011.03.025
   SIEGEL EG, 1982, DIABETES, V31, P265, DOI 10.2337/diabetes.31.3.265
   Vezzani A, 2011, NAT REV NEUROL, V7, P31, DOI 10.1038/nrneurol.2010.178
   Xiong ZQ, 2003, J NEUROSCI, V23, P955
   Yang RL, 2008, J CLIN BIOCHEM NUTR, V43, P154, DOI 10.3164/jcbn.2008044
NR 31
TC 5
Z9 5
U1 0
U2 1
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 0028-3886
EI 1998-4022
J9 NEUROL INDIA
JI Neurol. India
PD JUL-AUG
PY 2021
VL 69
IS 4
BP 957
EP 961
AR PMID 34507420
DI 10.4103/0028-3886.325371
PG 5
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA YY8JS
UT WOS:000755032000032
PM 34507420
DA 2025-06-11
ER

PT J
AU Galili, O
   Versari, D
   Sattler, KJ
   Olson, ML
   Mannheim, D
   McConnell, JP
   Chade, AR
   Lerman, LO
   Lerman, A
AF Galili, Offer
   Versari, Daniele
   Sattler, Katherine J.
   Olson, Monica L.
   Mannheim, Dallit
   McConnell, Joseph P.
   Chade, Alejandro R.
   Lerman, Lilach O.
   Lerman, Amir
TI Early experimental obesity is associated with coronary endothelial
   dysfunction and oxidative stress
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE endothelium; vasodilation; permeability; leptin
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; NITRIC-OXIDE; EXPERIMENTAL
   HYPERCHOLESTEROLEMIA; INDUCED HYPERTENSION; CARDIOVASCULAR RISK;
   RECEPTOR ANTAGONISM; VASCULAR-DISEASE; BLOOD-PRESSURE; LEPTIN
AB Obesity is independently associated with increased cardiovascular risk. However, since established obesity clusters with various cardiovascular risk factors, configuring the metabolic syndrome, the early effects of obesity on vascular function are still poorly understood. The current study was designed to evaluate the effect of early obesity on coronary endothelial function in a new animal model of swine obesity. As to method, juvenile domestic crossbred pigs were randomized to either high-fat/high-calorie diet (HF) or normal chow diet for 12 wk. Coronary microvascular permeability and abdominal wall fat were determined by using electron beam computerized tomography. Epicardial endothelial function and oxidative stress were measured in vitro. Systemic oxidative stress, renin-angiotensin activity, leptin levels, and parameters of insulin sensitivity were evaluated. As a result, HF pigs were characterized by abdominal obesity, hypertension, and elevated plasma lysophosphatidylcholine and leptin in the presence of increased insulin sensitivity. Coronary endothelium-dependent vasorelaxation was reduced in HF pigs and myocardial microvascular permeability increased compared with those values in normal pigs. Systemic redox status in HF pigs was similar to that in normal pigs, whereas the coronary endothelium demonstrated higher content of superoxide anions, nitrotyrosine, and NADPH-oxidase subunits, indicating increased tissue oxidative stress. In conclusion, the current study shows that early obesity is characterized by increased vascular oxidative stress and endothelial dysfunction in association with increased levels of leptin and before the development of insulin resistance and systemic oxidative stress. Vascular dysfunction is therefore an early manifestation of obesity and might contribute to the increased cardiovascular risk, independently of insulin resistance.
C1 Mayo Clin, Coll Med, Dept Cardiovasc Dis, Div Cardiovasc Dis, Rochester, MN 55905 USA.
   Mayo Clin, Coll Med, Dept Lab Med & Pathol, Rochester, MN 55905 USA.
   Mayo Clin, Coll Med, Dept Hypertens & Nephrol, Rochester, MN 55905 USA.
C3 Mayo Clinic; Mayo Clinic; Mayo Clinic
RP Lerman, A (corresponding author), Mayo Clin, Coll Med, Dept Cardiovasc Dis, Div Cardiovasc Dis, 200 1st St SW, Rochester, MN 55905 USA.
EM lerman.amir@mayo.edu
RI Lerman, Lilach/M-4962-2017
OI /0000-0003-3175-3972
FU NHLBI NIH HHS [K-24-HL-69840-02, R01-HL-63911, R01-HL-77131] Funding
   Source: Medline
CR Al Suwaidi J, 2001, J AM COLL CARDIOL, V37, P1523, DOI 10.1016/S0735-1097(01)01212-8
   Al Suwaidi J, 2000, CIRCULATION, V101, P948, DOI 10.1161/01.CIR.101.9.948
   Balasubramaniyan V, 2006, LIFE SCI, V78, P831, DOI 10.1016/j.lfs.2005.05.079
   Beltowski J, 2004, LIFE SCI, V74, P2987, DOI 10.1016/j.lfs.2003.10.029
   Berry C, 2000, CIRCULATION, V101, P2206, DOI 10.1161/01.CIR.101.18.2206
   Best PJM, 1999, ARTERIOSCL THROM VAS, V19, P2769, DOI 10.1161/01.ATV.19.11.2769
   Bonetti PO, 2003, ATHEROSCLEROSIS, V168, P367, DOI 10.1016/S0021-9150(03)00141-2
   Bonow RO, 2003, NEW ENGL J MED, V348, P2057, DOI 10.1056/NEJMp030053
   Brook RD, 2001, AM J CARDIOL, V88, P1264, DOI 10.1016/S0002-9149(01)02088-4
   Caballero AE, 2003, OBES RES, V11, P1278, DOI 10.1038/oby.2003.174
   Cersosimo E, 2006, DIABETES-METAB RES, V22, P423, DOI 10.1002/dmrr.634
   Chade AR, 2003, AM J HYPERTENS, V16, P111, DOI 10.1016/S08957061(02)03202-8
   Considine RV, 1996, NEW ENGL J MED, V334, P292, DOI 10.1056/NEJM199602013340503
   de Kreutzenberg SV, 2000, J CLIN ENDOCR METAB, V85, P793, DOI 10.1210/jc.85.2.793
   Eisenmann JC, 2005, AM HEART J, V149, P46, DOI 10.1016/j.ahj.2004.07.016
   Fornoni A, 2005, CURR HYPERTENS REP, V7, P88, DOI 10.1007/s11906-005-0080-6
   Freeman JE, 1996, J CARDIOVASC PHARM, V28, P345, DOI 10.1097/00005344-199609000-00001
   Froese DE, 1999, MOL CELL BIOCHEM, V197, P1, DOI 10.1023/A:1006847929334
   GLOMSET JA, 1968, J LIPID RES, V9, P155
   GLOMSET JA, 1962, BIOCHIM BIOPHYS ACTA, V65, P128, DOI 10.1016/0006-3002(62)90156-7
   Gokce N, 2003, J AM COLL CARDIOL, V41, P1769, DOI 10.1016/S0735-1097(03)00333-4
   Greco A, 2000, NEUROCHEM RES, V25, P1357, DOI 10.1023/A:1007608615682
   Grundy SM, 2006, CURR OPIN CARDIOL, V21, P1, DOI 10.1097/01.hco.0000200416.65370.a0
   Gunnett CA, 2001, ARTERIOSCL THROM VAS, V21, P1281, DOI 10.1161/hq0801.093509
   Hall JE, 2001, AM J HYPERTENS, V14, p103S, DOI 10.1016/S0895-7061(01)02077-5
   Huang F, 2005, AM J PHYSIOL-LUNG C, V289, pL176, DOI 10.1152/ajplung.00003.2005
   Huang TY, 2002, J BIOMED SCI, V9, P327, DOI 10.1007/BF02256588
   Kern PA, 2001, AM J PHYSIOL-ENDOC M, V280, pE745
   Knudson JD, 2005, AM J PHYSIOL-HEART C, V289, pH48, DOI 10.1152/ajpheart.01159.2004
   Kouglas P, 2006, MED SCI MONITOR, V12, pRA5
   Lerman A, 2005, CIRCULATION, V111, P363, DOI 10.1161/01.CIR.0000153339.27064.14
   Lerman LO, 1999, J COMPUT ASSIST TOMO, V23, P390, DOI 10.1097/00004728-199905000-00013
   Mark AL, 1999, J HYPERTENS, V17, P1949, DOI 10.1097/00004872-199917121-00026
   Naderali EK, 2001, CLIN SCI, V100, P635, DOI 10.1042/cs1000635
   Noronha BT, 2005, DIABETES, V54, P1082, DOI 10.2337/diabetes.54.4.1082
   Prasad A, 2004, CIRCULATION, V110, P1507, DOI 10.1161/01.CIR.0000141736.76561.78
   Qiao J, 2006, AM J PHYSIOL-LUNG C, V291, pL91, DOI 10.1152/ajplung.00508.2005
   Reaven G, 2004, ENDOCRIN METAB CLIN, V33, P283, DOI 10.1016/j.ecl.2004.03.002
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Rodriguez-Porcel M, 2003, ARTERIOSCL THROM VAS, V23, P885, DOI 10.1161/01.ATV.0000069209.26507.BF
   Rodriguez-Porcel M, 2001, HYPERTENSION, V37, P774, DOI 10.1161/01.HYP.37.2.774
   Safaya R, 2005, J SURG RES, V126, P182, DOI 10.1016/j.jss.2005.01.015
   Schutte R, 2005, J HUM HYPERTENS, V19, P535, DOI 10.1038/sj.jhh.1001856
   Shamsuzzaman ASM, 2004, CIRCULATION, V109, P2181, DOI 10.1161/01.CIR.0000127960.28627.75
   Shek EW, 1998, HYPERTENSION, V31, P409, DOI 10.1161/01.HYP.31.1.409
   Shen W, 2003, OBES RES, V11, P5, DOI 10.1038/oby.2003.3
   Snell-Bergeon JK, 2004, INT J OBESITY, V28, P1594, DOI 10.1038/sj.ijo.0802796
   Soccio M, 2005, EUR J CLIN INVEST, V35, P305, DOI 10.1111/j.1365-2362.2005.01500.x
   Steinberg HO, 1996, J CLIN INVEST, V97, P2601, DOI 10.1172/JCI118709
   Strauss RS, 2001, JAMA-J AM MED ASSOC, V286, P2845, DOI 10.1001/jama.286.22.2845
   Suda O, 2005, ARTERIOSCL THROM VAS, V25, P506, DOI 10.1161/01.ATV.0000153284.81572.f0
   SUTHERLAND WHF, 1979, ATHEROSCLEROSIS, V34, P319, DOI 10.1016/S0021-9150(79)80009-X
   Targonski PV, 2003, CIRCULATION, V107, P2805, DOI 10.1161/01.CIR.0000072765.93106.EE
   VAN HV, 2000, OBES RES, V8, P337
   Vaziri ND, 1997, KIDNEY INT, V52, P1042, DOI 10.1038/ki.1997.426
   Weiss R, 2004, NEW ENGL J MED, V350, P2362, DOI 10.1056/NEJMoa031049
   Woo KS, 2004, CIRCULATION, V109, P1981, DOI 10.1161/01.CIR.0000126599.47470.BE
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yan SY, 2005, SURGERY, V138, P464, DOI 10.1016/j.surg.2005.06.027
NR 59
TC 150
Z9 169
U1 0
U2 5
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD FEB
PY 2007
VL 292
IS 2
BP H904
EP H911
DI 10.1152/ajpheart.00628.2006
PG 8
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 134FK
UT WOS:000244068700022
PM 17012356
DA 2025-06-11
ER

PT J
AU Rangel-Huerta, OD
   Pastor-Villaescusa, B
   Gil, A
AF Rangel-Huerta, Oscar Daniel
   Pastor-Villaescusa, Belen
   Gil, Angel
TI Are we close to defining a metabolomic signature of human obesity? A
   systematic review of metabolomics studies
SO METABOLOMICS
LA English
DT Review
DE Metabolomics; Obesityand overweight; Metabolic profiling; Weight loss;
   Dietary intervention
ID BODY-MASS INDEX; CARDIOMETABOLIC RISK-FACTORS; VISCERAL ADIPOSE-TISSUE;
   TRIMETHYLAMINE-N-OXIDE; CORONARY-HEART-DISEASE; FATTY-ACID-COMPOSITION;
   INSULIN-RESISTANCE; WEIGHT-LOSS; AMINO-ACID; BRANCHED-CHAIN
AB IntroductionObesity is a disorder characterized by a disproportionate increase in body weight in relation to height, mainly due to the accumulation of fat, and is considered a pandemic of the present century by many international health institutions. It is associated with several non-communicable chronic diseases, namely, metabolic syndrome, type 2 diabetes mellitus (T2DM), cardiovascular diseases (CVD), and cancer. Metabolomics is a useful tool to evaluate changes in metabolites due to being overweight and obesity at the body fluid and cellular levels and to ascertain metabolic changes in metabolically unhealthy overweight and obese individuals (MUHO) compared to metabolically healthy individuals (MHO).ObjectivesWe aimed to conduct a systematic review (SR) of human studies focused on identifying metabolomic signatures in obese individuals and obesity-related metabolic alterations, such as inflammation or oxidative stress.MethodsWe reviewed the literature to identify studies investigating the metabolomics profile of human obesity and that were published up to May 7th, 2019 in SCOPUS and PubMed through an SR. The quality of reporting was evaluated using an adapted of QUADOMICS.ResultsThirty-three articles were included and classified according to four types of approaches. (i) studying the metabolic signature of obesity, (ii) studying the differential responses of obese and non-obese subjects to dietary challenges (iii) studies that used metabolomics to predict weight loss and aimed to assess the effects of weight loss interventions on the metabolomics profiles of overweight or obese human subjects (iv) articles that studied the effects of specific dietary patterns or dietary compounds on obesity-related metabolic alterations in humans.ConclusionThe present SR provides state-of-the-art information about the use of metabolomics as an approach to understanding the dynamics of metabolic processes involved in human obesity and emphasizes metabolic signatures related to obesity phenotypes.
C1 [Rangel-Huerta, Oscar Daniel] Univ Oslo, Dept Nutr, Fac Med, Oslo, Norway.
   [Rangel-Huerta, Oscar Daniel] Norwegian Vet Inst, Oslo, Norway.
   [Pastor-Villaescusa, Belen] Univ Munich, Med Ctr, LMU Ludwig Maximilians Univ Munchen, Div Metab & Nutr Med,Dr von Hauner Childrens Hosp, Munich, Germany.
   [Pastor-Villaescusa, Belen] Helmholtz Zentrum Munchen, Inst Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany.
   [Gil, Angel] Univ Granada, Inst Nutr & Food Technol Jose Mataix, Dept Biochem & Mol Biol 2, Ctr Biomed Res, Granada, Spain.
   [Gil, Angel] Inst Invest Biosanitaria Ibs Granada, Granada, Spain.
   [Gil, Angel] Physiopathol Obes & Nutr Networking Biomed Res Ct, Madrid, Spain.
C3 University of Oslo; Norwegian Veterinary Institute; University of
   Munich; Helmholtz Association; Helmholtz-Center Munich - German Research
   Center for Environmental Health; University of Granada; Instituto de
   Investigacion Biosanitaria IBS Granada
RP Gil, A (corresponding author), Univ Granada, Inst Nutr & Food Technol Jose Mataix, Dept Biochem & Mol Biol 2, Ctr Biomed Res, Granada, Spain.; Gil, A (corresponding author), Inst Invest Biosanitaria Ibs Granada, Granada, Spain.; Gil, A (corresponding author), Physiopathol Obes & Nutr Networking Biomed Res Ct, Madrid, Spain.
EM agil@ugr.es
RI Rangel-Huerta, Oscar/Q-7804-2018; Pastor-Villaescusa,
   Belén/GRF-0832-2022; Rangel Huerta, Oscar Daniel/I-4019-2015; Pastor
   Villaescusa, Belen/U-2325-2017; Gil, Angel/L-2275-2014
OI Rangel Huerta, Oscar Daniel/0000-0001-8585-0108; Pastor Villaescusa,
   Belen/0000-0003-0817-6804; Gil, Angel/0000-0001-7663-0939
FU European Union [609020]; Alfonso Martin Escudero Foundation, Spain
FX ODRH has received funding from the European Union Seventh Framework
   Programme (FP7-PEOPLE-2013-COFUND) under grant agreement no 609020 -
   Scientia Fellows. BPV is supported by a grant to postdoctoral
   researchers at foreign universities and research centers from the
   Alfonso Martin Escudero Foundation, Spain.
CR Abu Bakar MH, 2015, MOL BIOSYST, V11, P1742, DOI 10.1039/c5mb00158g
   Adams SH, 2011, ADV NUTR, V2, P445, DOI 10.3945/an.111.000737
   Adeva-Andany M, 2018, AMINO ACIDS, V50, P11, DOI 10.1007/s00726-017-2508-0
   Afshin A, 2017, NEW ENGL J MED, V377, P13, DOI 10.1056/NEJMoa1614362
   Aguilera CM, 2015, INT J MOL SCI, V16, P7723, DOI 10.3390/ijms16047723
   Almanza-Aguilera E, 2018, J PROTEOME RES, V17, P2600, DOI 10.1021/acs.jproteome.8b00042
   [Anonymous], 2021, OB OV
   [Anonymous], 2012, INT J OBESITY, DOI DOI 10.1038/ijo.2011.129
   [Anonymous], CLIN NUTR
   Badoud F, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0134613
   Badoud F, 2015, FASEB J, V29, P748, DOI 10.1096/fj.14-263913
   Bagheri M, 2019, LIPIDS HEALTH DIS, V18, DOI 10.1186/s12944-019-1037-0
   Bagheri M, 2018, J PROTEOME RES, V17, P1452, DOI 10.1021/acs.jproteome.7b00802
   Bak AM, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0200817
   Baker JL, 2007, NEW ENGL J MED, V357, P2329, DOI 10.1056/NEJMoa072515
   Baker PR, 2015, OBESITY, V23, P981, DOI 10.1002/oby.21046
   Baldrick FR, 2018, AM J CLIN NUTR, V108, P688, DOI 10.1093/ajcn/nqy147
   Bann D, 2015, OBESITY, V23, P1486, DOI 10.1002/oby.21092
   Barber MN, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041456
   BarrettConnor E, 1996, J CLIN ENDOCR METAB, V81, P59, DOI 10.1210/jc.81.1.59
   Bastard JP, 2006, EUR CYTOKINE NETW, V17, P4
   Bélanger C, 2006, STEROIDS, V71, P674, DOI 10.1016/j.steroids.2006.04.008
   Bennett BJ, 2013, CELL METAB, V17, P49, DOI 10.1016/j.cmet.2012.12.011
   Blouin K, 2005, METABOLISM, V54, P1034, DOI 10.1016/j.metabol.2005.03.006
   Bohula EA, 2018, NEW ENGL J MED, V379, P1107, DOI 10.1056/NEJMoa1808721
   Brandacher G, 2007, CURR DRUG METAB, V8, P289, DOI 10.2174/138920007780362590
   Brestoff JR, 2015, CELL, V161, P146, DOI 10.1016/j.cell.2015.02.022
   Butte NF, 2015, AM J CLIN NUTR, V102, P256, DOI 10.3945/ajcn.115.111872
   Calvani R, 2014, J CLIN GASTROENTEROL, V48, pS5, DOI 10.1097/MCG.0000000000000236
   Cañete R, 2007, EUR J NUTR, V46, P181, DOI 10.1007/s00394-007-0648-9
   Caputo T, 2017, FEBS LETT, V591, P3061, DOI 10.1002/1873-3468.12742
   Carayol M, 2017, J PROTEOME RES, V16, P3137, DOI 10.1021/acs.jproteome.6b01062
   Casson PR, 2010, J CLIN ENDOCR METAB, V95, P4276, DOI 10.1210/jc.2009-2390
   Chen S, 2017, ONCOTARGET, V8, P38184, DOI 10.18632/oncotarget.17132
   Cho K, 2017, PEDIATR OBES, V12, P93, DOI 10.1111/ijpo.12114
   Cirulli ET, 2019, CELL METAB, V29, P488, DOI 10.1016/j.cmet.2018.09.022
   Connor SC, 2010, MOL BIOSYST, V6, P909, DOI 10.1039/b914182k
   Considine EC, 2018, METABOLOMICS, V14, DOI 10.1007/s11306-017-1299-3
   Creek DJ, 2014, METABOLOMICS, V10, P350, DOI 10.1007/s11306-014-0656-8
   Dadvar S, 2018, J INTERN MED, V284, P519, DOI 10.1111/joim.12830
   De Simone M, 2001, J ENDOCRINOL INVEST, V24, P438, DOI 10.1007/BF03351044
   DEPERGOLA G, 1994, INT J OBESITY, V18, P659
   Du FY, 2013, BIOMARK RES, V1, DOI 10.1186/2050-7771-1-17
   Duft RG, 2017, J PROTEOME RES, V16, P2151, DOI 10.1021/acs.jproteome.6b00967
   Eid HMA, 2004, METABOLISM, V53, P1574, DOI 10.1016/j.metabol.2004.06.026
   El Assar M, 2016, J PHYSIOL-LONDON, V594, P3045, DOI 10.1113/JP271836
   Ezzati M, 2017, LANCET, V390, P2627, DOI [10.1016/S0140-6736(17)32129-3, 10.1016/s0140-6736(17)32129-3]
   Fattorusso E, 2000, J AGR FOOD CHEM, V48, P3455, DOI 10.1021/jf000331v
   Fattuoni C, 2018, PLACENTA, V61, P89, DOI 10.1016/j.placenta.2017.11.014
   Favennec M, 2015, OBESITY, V23, P2066, DOI 10.1002/oby.21199
   Feldman A, 2019, DIABETES METAB, V45, P132, DOI 10.1016/j.diabet.2018.09.003
   FELIG P, 1969, NEW ENGL J MED, V281, P811, DOI 10.1056/NEJM196910092811503
   Fidler MC, 2011, J CLIN ENDOCR METAB, V96, P3067, DOI 10.1210/jc.2011-1256
   Fiehn O, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015234
   Foerster J, 2015, METABOLISM, V64, P1348, DOI 10.1016/j.metabol.2015.07.004
   Gagnon SS, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01005
   Gall WE, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010883
   Gates MA, 2013, J CLIN ENDOCR METAB, V98, P2442, DOI 10.1210/jc.2012-2582
   Gawlik A, 2016, J CLIN ENDOCR METAB, V101, P4329, DOI 10.1210/jc.2016-1754
   Geidenstam N, 2017, INT J OBESITY, V41, P1369, DOI 10.1038/ijo.2017.124
   Geidenstam N, 2017, INT J ENDOCRINOL, V2017, DOI 10.1155/2017/6490473
   Geidenstam N, 2016, DIABETES RES CLIN PR, V113, P187, DOI 10.1016/j.diabres.2015.12.024
   Geidenstam N, 2014, OBESITY, V22, P2388, DOI 10.1002/oby.20868
   Gibney MJ, 2005, AM J CLIN NUTR, V82, P497, DOI 10.1093/ajcn/82.3.497
   Gil A, 2007, BRIT J NUTR, V98, pS121, DOI 10.1017/S0007114507838050
   Gil-Campos M, 2004, CLIN NUTR, V23, P963, DOI 10.1016/j.clnu.2004.04.010
   Gil-Campos M, 2009, NUTR HOSP, V24, P607, DOI 10.3305/nh.2009.24.5.4491
   Gogna N, 2015, MOL BIOSYST, V11, P595, DOI 10.1039/c4mb00507d
   Gu YJ, 2013, J PROTEOME RES, V12, P5801, DOI 10.1021/pr4008199
   Guo SS, 2002, AM J CLIN NUTR, V76, P653, DOI 10.1093/ajcn/76.3.653
   Halford JCG, 2005, CURR DRUG TARGETS, V6, P201, DOI 10.2174/1389450053174550
   Hanzu FA, 2014, OBESITY, V22, P698, DOI 10.1002/oby.20541
   Haufe S, 2016, NUTR METAB CARDIOVAS, V26, P637, DOI 10.1016/j.numecd.2016.03.013
   He QH, 2012, J NUTR BIOCHEM, V23, P133, DOI 10.1016/j.jnutbio.2010.11.007
   He ZH, 2018, INT J OBESITY, V42, P1366, DOI 10.1038/s41366-018-0033-1
   Heimerl S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0111348
   Hellmuth C, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2108909
   Hernández-Alonso P, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201700975
   Hibberd AA, 2019, BENEF MICROBES, V10, P121, DOI [10.3920/BM2018.0028, 10.3920/bm2018.0028]
   Hivert MF, 2015, J DEV ORIG HLTH DIS, V6, P65, DOI 10.1017/S204017441500001X
   Ho JE, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0148361
   Hodge AM, 2007, NUTR METAB CARDIOVAS, V17, P415, DOI 10.1016/j.numecd.2006.04.005
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   Houttu N, 2018, CLIN NUTR, V37, P1955, DOI 10.1016/j.clnu.2017.12.013
   Islam MS, 2012, ANN NUTR METAB, V61, P57, DOI 10.1159/000338440
   Iwasa M, 2015, OBES RES CLIN PRACT, V9, P293, DOI 10.1016/j.orcp.2015.01.003
   Jakobsen MU, 2009, AM J CLIN NUTR, V89, P1425, DOI 10.3945/ajcn.2008.27124
   Johnson RJ, 2011, SEMIN NEPHROL, V31, P394, DOI 10.1016/j.semnephrol.2011.08.002
   Kang M, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0887-1
   Khan MZH, 2016, J ENVIRON PUBLIC HEA, V2016, DOI 10.1155/2016/7869080
   Kien CL, 2013, DIABETES, V62, P1054, DOI 10.2337/db12-0363
   Kim HY, 2014, NUTRITION, V30, P1433, DOI 10.1016/j.nut.2014.04.013
   Kim HJ, 2011, J PROTEOME RES, V10, P722, DOI 10.1021/pr100892r
   Kim JY, 2010, J PROTEOME RES, V9, P4368, DOI 10.1021/pr100101p
   Kim M. J., 2013, J OBESITY, V2013
   Kim YJ, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030233
   Kim Y, 2010, BIOTECHNOL J, V5, P99, DOI 10.1002/biot.200900228
   Koeth RA, 2013, NAT MED, V19, P576, DOI 10.1038/nm.3145
   Koves TR, 2008, CELL METAB, V7, P45, DOI 10.1016/j.cmet.2007.10.013
   Kraus WE, 2016, J GERONTOL A-BIOL, V71, P1507, DOI 10.1093/gerona/glw031
   Krishnan E, 2012, AM J EPIDEMIOL, V176, P108, DOI 10.1093/aje/kws002
   Leal-Witt MJ, 2018, INT J OBESITY, V42, P72, DOI 10.1038/ijo.2017.201
   Lee BC, 2014, BBA-MOL BASIS DIS, V1842, P446, DOI 10.1016/j.bbadis.2013.05.017
   Lee S, 2016, CELL METAB, V24, P172, DOI 10.1016/j.cmet.2016.05.026
   Libert DM, 2018, PEERJ, V6, DOI 10.7717/peerj.5410
   Lipsky LM, 2016, DIABETES RES CLIN PR, V120, P97, DOI 10.1016/j.diabres.2016.07.028
   Liu SH, 2013, NATURE, V502, P550, DOI 10.1038/nature12710
   Lumbreras B, 2008, CLIN BIOCHEM, V41, P1316, DOI 10.1016/j.clinbiochem.2008.06.018
   Ma HJ, 2014, BEST PRACT RES CL GA, V28, P573, DOI 10.1016/j.bpg.2014.07.004
   Makrecka-Kuka M, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-17797-x
   Maltais-Payette I, 2018, NUTR METAB, V15, DOI 10.1186/s12986-018-0316-5
   Mäntyselkä A, 2018, J CLIN ENDOCR METAB, V103, P2592, DOI 10.1210/jc.2018-00184
   Marco-Ramell A, 2018, J PROTEOME RES, V17, P2307, DOI 10.1021/acs.jproteome.7b00855
   Mayengbam S, 2019, J NUTR BIOCHEM, V64, P228, DOI 10.1016/j.jnutbio.2018.11.003
   Meucci M, 2017, CURR PEDIATR REV, V13, P144, DOI 10.2174/1573396313666170113145553
   Mihalik SJ, 2012, DIABETES CARE, V35, P605, DOI [10.2337/DC11-1577, 10.2337/dc11-1577]
   Mills HL, 2019, BMC MED, V17, DOI 10.1186/s12916-018-1248-7
   Mogri M, 2013, CLIN ENDOCRINOL, V78, P593, DOI 10.1111/cen.12018
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Mook-Kanamori DO, 2014, J CLIN ENDOCR METAB, V99, pE479, DOI 10.1210/jc.2013-3596
   Moore SC, 2014, METABOLOMICS, V10, P259, DOI 10.1007/s11306-013-0574-1
   Morris C, 2012, P NUTR SOC, V71, P634, DOI 10.1017/S0029665112000699
   Mueller JW, 2015, ENDOCR REV, V36, P526, DOI 10.1210/er.2015-1036
   Munipally PK, 2011, ARCH PHYSIOL BIOCHEM, V117, P254, DOI 10.3109/13813455.2011.623705
   Munukka E, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.02323
   Murugesan G, 2003, J MOL CELL CARDIOL, V35, P1375, DOI 10.1016/j.yjmcc.2003.08.004
   Newell-Fugate AE, 2017, REPRODUCTION, V153, pR133, DOI 10.1530/REP-16-0417
   Newgard CB, 2017, CELL METAB, V25, P43, DOI 10.1016/j.cmet.2016.09.018
   Newgard CB, 2009, CELL METAB, V9, P311, DOI 10.1016/j.cmet.2009.02.002
   Nieman DC, 2012, PLANT FOOD HUM NUTR, V67, P415, DOI 10.1007/s11130-012-0325-x
   Nieman DC, 2012, J ALTERN COMPLEM MED, V18, P700, DOI 10.1089/acm.2011.0443
   O'Neil PM, 2012, OBESITY, V20, P1426, DOI 10.1038/oby.2012.66
   Oberbach A, 2011, J PROTEOME RES, V10, P4769, DOI 10.1021/pr2005555
   Pardo F, 2017, MOL ASPECTS MED, V55, P90, DOI 10.1016/j.mam.2017.01.003
   Park S, 2015, MOL CELLS, V38, P587, DOI 10.14348/molcells.2015.0126
   Perez-Cornago A, 2014, J PHYSIOL BIOCHEM, V70, P593, DOI 10.1007/s13105-013-0311-2
   Piening BD, 2018, CELL SYST, V6, P157, DOI 10.1016/j.cels.2017.12.013
   Pietiläinen KH, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000218
   Putri SP, 2013, J BIOSCI BIOENG, V116, P9, DOI 10.1016/j.jbiosc.2013.01.004
   Rangel-Huerta OD, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17122072
   Rauschert S, 2017, OBESITY, V25, P1549, DOI 10.1002/oby.21915
   Rauschert S, 2017, ANN NUTR METAB, V70, P201, DOI 10.1159/000459635
   Rauschert S, 2016, J CLIN ENDOCR METAB, V101, P871, DOI 10.1210/jc.2015-3525
   Rauschert S, 2014, ANN NUTR METAB, V64, P314, DOI 10.1159/000365040
   Reinehr T, 2005, J CLIN ENDOCR METAB, V90, P5588, DOI 10.1210/jc.2005-0438
   Remedios C, 2012, OBES SURG, V22, P945, DOI 10.1007/s11695-012-0655-7
   Romo-Hualde A, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0750-4
   Ruebel ML, 2019, AM J PHYSIOL-ENDOC M, V316, pE383, DOI 10.1152/ajpendo.00401.2018
   Rupérez AI, 2018, NUTR METAB CARDIOVAS, V28, P524, DOI 10.1016/j.numecd.2018.02.006
   Sailer M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0063950
   Salek RM, 2015, METABOLOMICS, V11, P1587, DOI 10.1007/s11306-015-0810-y
   Schooneman MG, 2016, ARCH BIOCHEM BIOPHYS, V606, P73, DOI 10.1016/j.abb.2016.07.013
   Schooneman MG, 2013, DIABETES, V62, P1, DOI 10.2337/db12-0466
   Shah SH, 2010, CIRC-CARDIOVASC GENE, V3, P207, DOI 10.1161/CIRCGENETICS.109.852814
   She PX, 2007, AM J PHYSIOL-ENDOC M, V293, pE1552, DOI 10.1152/ajpendo.00134.2007
   Shore SA, 2016, AM J RESP CELL MOL, V54, P609, DOI 10.1165/rcmb.2016-0052PS
   Smith SR, 2010, NEW ENGL J MED, V363, P245, DOI 10.1056/NEJMoa0909809
   Sorrow P, 2019, PEDIATR OBES, V14, DOI 10.1111/ijpo.12465
   Stroeve JHM, 2016, OBESITY, V24, P379, DOI 10.1002/oby.21361
   Sumner LW, 2007, METABOLOMICS, V3, P211, DOI 10.1007/s11306-007-0082-2
   Sumner LW, 2014, METABOLOMICS, V10, P1047, DOI 10.1007/s11306-014-0739-6
   Taneli F, 2010, CLIN BIOCHEM, V43, P1236, DOI 10.1016/j.clinbiochem.2010.07.026
   Tang WHW, 2013, NEW ENGL J MED, V368, P1575, DOI 10.1056/NEJMoa1109400
   Tang WHW, 2009, J AM COLL CARDIOL, V53, P2061, DOI 10.1016/j.jacc.2009.02.036
   Tecott LH, 2007, CELL METAB, V6, P352, DOI 10.1016/j.cmet.2007.09.012
   Tilg H, 2006, NAT REV IMMUNOL, V6, P772, DOI 10.1038/nri1937
   Troseid M, 2015, J INTERN MED, V277, P717, DOI 10.1111/joim.12328
   Tulipani S, 2016, OBESITY, V24, P2451, DOI 10.1002/oby.21686
   Tulipani S, 2016, CLIN CHIM ACTA, V463, P53, DOI 10.1016/j.cca.2016.10.005
   Ulaszewska MM, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201800384
   Vallgårda S, 2017, EUR J CLIN NUTR, V71, P1263, DOI 10.1038/ejcn.2017.103
   Vandewalle S, 2015, CURR OPIN ENDOCRINOL, V22, P230, DOI 10.1097/MED.0000000000000160
   Vinayavekhin N, 2010, ACS CHEM BIOL, V5, P91, DOI 10.1021/cb900271r
   Vitale C, 2010, FUND CLIN PHARMACOL, V24, P675, DOI 10.1111/j.1472-8206.2010.00817.x
   Wahl S, 2012, OBESITY FACTS, V5, P660, DOI 10.1159/000343204
   Wang SM, 2018, NUTR METAB CARDIOVAS, V28, P112, DOI 10.1016/j.numecd.2017.09.009
   Wang ZN, 2011, NATURE, V472, P57, DOI 10.1038/nature09922
   WHO, 2014, GLOBAL STATUS REPORT ON VIOLENCE PREVENTION 2014, P1
   Widén E, 2012, DIABETES CARE, V35, P850, DOI 10.2337/dc11-1365
   Williams EP, 2015, CURR OBES REP, V4, P363, DOI 10.1007/s13679-015-0169-4
   Williams R, 2006, MOL BIOSYST, V2, P174, DOI 10.1039/b516356k
   WOODBURY JF, 1971, J CLIN INVEST, V50, P2531, DOI 10.1172/JCI106753
   Xie BG, 2012, J BIOMED BIOTECHNOL, DOI 10.1155/2012/805683
   Xie GX, 2014, J PROTEOME RES, V13, P4062, DOI 10.1021/pr500434s
   Xu MY, 2018, J PROTEOME RES, V17, P2850, DOI 10.1021/acs.jproteome.8b00315
   Yabut JM, 2019, ENDOCR REV, V40, P1092, DOI 10.1210/er.2018-00283
   Yang Q, 2018, NAT REV MOL CELL BIO, V19, P654, DOI 10.1038/s41580-018-0044-8
   Yu HT, 2018, ASIA PAC J CLIN NUTR, V27, P1067, DOI 10.6133/apjcn.052018.07
   Villarreal-Pérez JZ, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-129
   Zeng MM, 2010, J PHARMACEUT BIOMED, V52, P265, DOI 10.1016/j.jpba.2010.01.002
   Zhai LL, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0134656
   Zhang A, 2013, OBES REV, V14, P344, DOI 10.1111/obr.12011
   Zhang F, 2017, ONCOTARGET, V8, P35460, DOI 10.18632/oncotarget.16727
   Zhao Q, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0159548
   Zhao X, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0160500
   Zheng H, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030108
   Zheng Y, 2016, AM J CLIN NUTR, V103, P505, DOI 10.3945/ajcn.115.117689
NR 198
TC 159
Z9 173
U1 2
U2 42
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1573-3882
EI 1573-3890
J9 METABOLOMICS
JI Metabolomics
PD JUN
PY 2019
VL 15
IS 6
AR 93
DI 10.1007/s11306-019-1553-y
PG 31
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ID3ZI
UT WOS:000471615200001
PM 31197497
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Ballesteros, MN
   Valenzuela, F
   Robles, AE
   Artalejo, E
   Aguilar, D
   Andersen, CJ
   Valdez, H
   Fernandez, ML
AF Nydia Ballesteros, Martha
   Valenzuela, Fabrizio
   Robles, Alma E.
   Artalejo, Elizabeth
   Aguilar, David
   Andersen, Catherine J.
   Valdez, Herlindo
   Fernandez, Maria Luz
TI One Egg per Day Improves Inflammation when Compared to an Oatmeal-Based
   Breakfast without Increasing Other Cardiometabolic Risk Factors in
   Diabetic Patients
SO NUTRIENTS
LA English
DT Article
ID DIETARY-CHOLESTEROL; CARBOHYDRATE RESTRICTION; INSULIN-RESISTANCE; LDL
   CHOLESTEROL; HDL CHOLESTEROL; CONSUMPTION; LUTEIN; BIOAVAILABILITY;
   POPULATION; METABOLISM
AB There is concern that egg intake may increase blood glucose in patients with type 2 diabetes mellitus (T2DM). However, we have previously shown that eggs reduce inflammation in patients at risk for T2DM, including obese subjects and those with metabolic syndrome. Thus, we hypothesized that egg intake would not alter plasma glucose in T2DM patients when compared to oatmeal intake. Our primary endpoints for this clinical intervention were plasma glucose and the inflammatory markers tumor necrosis factor (TNF)-alpha and interleukin 6 (IL-6). As secondary endpoints, we evaluated additional parameters of glucose metabolism, dyslipidemias, oxidative stress and inflammation. Twenty-nine subjects, 35-65 years with glycosylated hemoglobin (HbA1c) values <9% were recruited and randomly allocated to consume isocaloric breakfasts containing either one egg/day or 40 g of oatmeal with 472 mL of lactose-free milk/day for five weeks. Following a three-week washout period, subjects were assigned to the alternate breakfast. At the end of each period, we measured all primary and secondary endpoints. Subjects completed four-day dietary recalls and one exercise questionnaire for each breakfast period. There were no significant differences in plasma glucose, our primary endpoint, plasma lipids, lipoprotein size or subfraction concentrations, insulin, HbA1c, apolipoprotein B, oxidized LDL or C-reactive protein. However, after adjusting for gender, age and body mass index, aspartate amino-transferase (AST) (p < 0.05) and tumor necrosis factor (TNF)-alpha (p < 0.01), one of our primary endpoints were significantly reduced during the egg period. These results suggest that compared to an oatmeal-based breakfast, eggs do not have any detrimental effects on lipoprotein or glucose metabolism in T2DM. In contrast, eggs reduce AST and TNF-alpha in this population characterized by chronic low-grade inflammation.
C1 [Nydia Ballesteros, Martha; Valenzuela, Fabrizio; Robles, Alma E.; Artalejo, Elizabeth] CIAD, Hermosillo 83304, Sonora, Mexico.
   [Aguilar, David; Andersen, Catherine J.; Fernandez, Maria Luz] Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
   [Valdez, Herlindo] Hosp Ignacio Chavez, Hermosillo 83190, Sonora, Mexico.
C3 CIAD - Centro de Investigacion en Alimentacion y Desarrollo; University
   of Connecticut
RP Fernandez, ML (corresponding author), Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
EM nydia@ciad.mx; fabe_vi@hotmail.com; melina@ciad.mx; eartalejo@ciad.mx;
   david_178@hotmail.com; candersen@fairfield.edu; herlindov@yahoo.com.mx;
   maria-luz.fernandez@uconn.edu
RI ; Robles-Sardin, Alma-Elizabeth/M-7714-2015
OI Andersen, Catherine/0000-0001-9774-5030; Fernandez,
   Maria-Luz/0000-0002-1835-0792; Robles-Sardin,
   Alma-Elizabeth/0000-0003-2044-7793
FU Egg Nutrition Center
FX Supported by the Egg Nutrition Center from funds received by M.L.F.
CR Agrawal S, 2012, PUBLIC HEALTH NUTR, V15, P1065, DOI 10.1017/S1368980011002813
   Al-Sarraj T, 2010, NUTR METAB CARDIOVAS, V20, P720, DOI 10.1016/j.numecd.2009.06.004
   Albarran NB, 2006, PATIENT EDUC COUNS, V61, P191, DOI 10.1016/j.pec.2005.03.008
   Andersen CJ, 2013, LIPIDS, V48, P557, DOI 10.1007/s11745-013-3780-8
   Ballesteros M. N., 2013, British Journal of Medicine and Medical Research, V3, P2203
   Ballesteros MN, 2004, AM J CLIN NUTR, V80, P855, DOI 10.1093/ajcn/80.4.855
   Blesso CN, 2013, J CLIN LIPIDOL, V7, P463, DOI 10.1016/j.jacl.2013.03.008
   Blesso CN, 2013, METABOLISM, V62, P400, DOI 10.1016/j.metabol.2012.08.014
   Blesso CN, 2013, FOOD FUNCT, V4, P213, DOI 10.1039/c2fo30154g
   Chakrabarty Gayatri, 2002, Indian J Physiol Pharmacol, V46, P492
   Chung HY, 2004, J NUTR, V134, P1887, DOI 10.1093/jn/134.8.1887
   Djoussé L, 2009, DIABETES CARE, V32, P295, DOI 10.2337/dc08-1271
   Djoussé L, 2010, AM J CLIN NUTR, V92, P422, DOI 10.3945/ajcn.2010.29406
   FEINGOLD KR, 1992, ARTERIOSCLER THROMB, V12, P1496, DOI 10.1161/01.ATV.12.12.1496
   González-Villalpando C, 2014, SALUD PUBLICA MEXICO, V56, P11
   Greene CM, 2005, J NUTR, V135, P2793, DOI 10.1093/jn/135.12.2793
   Griffin John D, 2013, Curr Nutr Rep, V2, P274
   Gunness P, 2010, FOOD FUNCT, V1, P149, DOI 10.1039/c0fo00080a
   Gutierrez JP., 2012, Encuesta Nacional de Salud y Nutricion 2012. Resultados Nacionales
   Herron KL, 2003, J NUTR, V133, P1036, DOI 10.1093/jn/133.4.1036
   Kim JH, 2008, FREE RADICAL BIO MED, V45, P885, DOI 10.1016/j.freeradbiomed.2008.06.019
   Kim JE, 2011, J NUTR, V141, P1458, DOI 10.3945/jn.111.141630
   Kontoangelos K, 2014, NEUROENDOCRINOL LETT, V35, P159
   Lammert A, 2008, EXP CLIN ENDOCR DIAB, V116, P132, DOI 10.1055/s-2007-984456
   Li YH, 2013, ATHEROSCLEROSIS, V229, P524, DOI 10.1016/j.atherosclerosis.2013.04.003
   Lorenzo C, 2012, J CLIN ENDOCR METAB, V97, P793, DOI 10.1210/jc.2011-2272
   Mutungi G, 2010, J NUTR BIOCHEM, V21, P261, DOI 10.1016/j.jnutbio.2008.12.011
   Ng DS, 2013, CAN J DIABETES, V37, P319, DOI 10.1016/j.jcjd.2013.07.062
   Pearce KL, 2011, BRIT J NUTR, V105, P584, DOI 10.1017/S0007114510003983
   Pullinger CR, 2014, METAB SYNDR RELAT D, V12, P25, DOI 10.1089/met.2013.0086
   Qureshi AI, 2007, MED SCI MONITOR, V13, pCR1
   Radzeviciené L, 2012, PUBLIC HEALTH NUTR, V15, P1437, DOI 10.1017/S1368980012000614
   Ratliff JC, 2008, NUTR METAB, V5, DOI 10.1186/1743-7075-5-6
   Romero AL, 1998, J AM COLL NUTR, V17, P601, DOI 10.1080/07315724.1998.10718809
   Shin JY, 2013, AM J CLIN NUTR, V98, P146, DOI 10.3945/ajcn.112.051318
   Thongoun Pimonphan, 2013, Journal of the Medical Association of Thailand, V96, pS25
   Thurnham DI, 2007, NUTR RES REV, V20, P163, DOI 10.1017/S0954422407842235
   WELCH RW, 1994, BRIT J BIOMED SCI, V51, P260
   Wood RJ, 2006, J NUTR, V136, P384, DOI 10.1093/jn/136.2.384
   Zazpe I, 2013, NUTR HOSP, V28, P105, DOI 10.3305/nh.2013.28.1.6124
NR 40
TC 63
Z9 73
U1 0
U2 29
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2015
VL 7
IS 5
BP 3449
EP 3463
DI 10.3390/nu7053449
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CK5CT
UT WOS:000356240500023
PM 25970149
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Gupta, P
   Mehla, J
   Siddique, K
   Jamil, S
   Gupta, YK
AF Gupta, Pooja
   Mehla, Jogender
   Siddique, Khalid
   Jamil, Shakir
   Gupta, Yogendra Kumar
TI Anti-oxidant and Anti-inflammatory activity of Safoof Mohazzil: A
   traditional, Poly-herbal Unani formulation for Obesity
SO INDIAN JOURNAL OF TRADITIONAL KNOWLEDGE
LA English
DT Article
DE Safoof Mohazzil; Obesity; Inflammation; Oxidative stress; Metabolic
   syndrome
ID LIPID-PEROXIDATION; OXIDATIVE STRESS; POLYHERBAL FORMULATION;
   FREE-RADICALS; INFLAMMATION; DAMAGE; ASSAY
AB Inflammation and oxidative stress have been reported in obesity. Safoof Mohazzil, is a traditional formulation prescribed by Unani physicians for weight loss. In the present study, antioxidant and anti-inflammatory properties of Safoof Mohazzil were evaluated using pyrogallol induced hepatotoxicity and carrageenan induced paw edema, respectively, in male Wistar rats. For the antioxidant study, rats were treated with Safoof Mohazzil for 14 days at the doses of 250, 500 and 1000 mg/kg, p.o. On 14th day, 2 hrs after the last dose of Unani formulation, pyrogallol (100 mg/kg) was injected intraperitoneally and on next day the animals were sacrificed for estimation of hepatic oxidative stress markers (malondialdehyde and reduced glutathione). Safoof Mohazzil demonstrated dose-dependent anti-oxidant activity. To assess its anti-inflammatory property, Safoof Mohazzil was administered at the doses of 500 & 1000 mg/kg, p.o. for 7 days and on 7th day carrageenan was administered 1 hr after the last dose of Unani formulation. The change in paw volume was calculated at 1, 3 and 6 hrs. Significant anti-inflammatory activity was found at 1000 mg/kg dose which is the human equivalent of its anti-obesity dose. The antioxidant and anti-inflammatory activity of Safoof Mohazzil support its use in obesity and possibly metabolic syndrome.
C1 [Gupta, Pooja; Mehla, Jogender; Gupta, Yogendra Kumar] All India Inst Med Sci, Dept Pharmacol, New Delhi 110029, India.
   [Siddique, Khalid; Jamil, Shakir] Govt India, Minist Hlth & Family Welf, Cent Council Res Unani Med, Dept Ayurveda Yoga Unani Siddha & Homeopathy, New Delhi, India.
C3 All India Institute of Medical Sciences (AIIMS) New Delhi
RP Gupta, YK (corresponding author), All India Inst Med Sci, Dept Pharmacol, R 4012,4th Floor Teaching Block, New Delhi 110029, India.
EM drgupta.pooja@gmail.com; yk.ykgupta@gmail.com
RI Mehla, Jogender/M-1055-2019
OI Gupta, Pooja/0000-0002-3687-3853
FU Central Council for Research in Unani Medicine (CCRUM), Department of
   Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homoeopathy (AYUSH),
   Ministry of Health & Family Welfare, Government of India
FX The study was funded by Central Council for Research in Unani Medicine
   (CCRUM), Department of Ayurveda, Yoga and Naturopathy, Unani, Siddha and
   Homoeopathy (AYUSH), Ministry of Health & Family Welfare, Government of
   India. The Unani formulation was prepared by National Institute of
   Nutrition, Hyderabad, India for CCRUM. Mr Ritesh Kumar and Ms Shalu
   Arora assisted in execution of the study.
CR Allen RG, 1998, AGE, V21, P47, DOI 10.1007/s11357-998-0007-7
   Aruoma OI, 1998, J AM OIL CHEM SOC, V75, P199, DOI 10.1007/s11746-998-0032-9
   Bondia-Pons I, 2012, J PHYSIOL BIOCHEM, V68, P701, DOI 10.1007/s13105-012-0154-2
   Cazettes F, 2011, BRAIN RES, V1373, P101, DOI 10.1016/j.brainres.2010.12.008
   De Marino S, 2007, PHYTOCHEMISTRY, V68, P1805, DOI 10.1016/j.phytochem.2007.03.029
   Delaporte RH, 2002, J ETHNOPHARMACOL, V82, P127, DOI 10.1016/S0378-8741(02)00181-2
   ELLMAN GL, 1959, ARCH BIOCHEM BIOPHYS, V82, P70, DOI 10.1016/0003-9861(59)90090-6
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Geronikaki AA, 2006, COMB CHEM HIGH T SCR, V9, P425, DOI 10.2174/138620706777698481
   Gupta P, 2012, INDIAN J EXP BIOL, V50, P776
   Gupta YK, 2004, PHYTOTHER RES, V18, P362, DOI 10.1002/ptr.1272
   GUTTERIDGE JMC, 1995, CLIN CHEM, V41, P1819
   HARMAN D, 1984, AGE, V7, P111, DOI 10.1007/BF02431866
   Ibironke G F, 2012, Afr J Med Med Sci, V41, P205
   James P T, 2001, Obes Res, V9 Suppl 4, p228S, DOI 10.1038/oby.2001.123
   Jung K, 1996, FREE RADICAL BIO MED, V20, P613, DOI 10.1016/0891-5849(95)02090-X
   Lamprecht M., 2013, BR J NUTR, V16, P1
   Lee DY, 2013, MOLECULES, V18, P41, DOI 10.3390/molecules18010041
   Mohanty P, 2004, J CLIN ENDOCR METAB, V89, P2728, DOI 10.1210/jc.2003-032103
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   Ratheesh M, 2011, EXP TOXICOL PATHOL, V63, P285, DOI 10.1016/j.etp.2010.01.007
   Rikans LE, 1997, BBA-MOL BASIS DIS, V1362, P116, DOI 10.1016/S0925-4439(97)00067-7
   SIES H, 1986, ANGEW CHEM INT EDIT, V25, P1058, DOI 10.1002/anie.198610581
   Tran B, 2012, EXP DIABETES RES, DOI 10.1155/2012/683680
   Wani TA, 2012, INDIAN J BIOCHEM BIO, V49, P463
   WINROW VR, 1993, BRIT MED BULL, V49, P506, DOI 10.1093/oxfordjournals.bmb.a072627
   WINTER CA, 1962, P SOC EXP BIOL MED, V111, P544
   Yajnik CS, 2004, P NUTR SOC, V63, P387, DOI 10.1079/PNS2004365
NR 28
TC 3
Z9 3
U1 0
U2 0
PU NATL INST SCIENCE COMMUNICATION-NISCAIR
PI NEW DELHI
PA DR K S KRISHNAN MARG, PUSA CAMPUS, NEW DELHI 110 012, INDIA
SN 0972-5938
EI 0975-1068
J9 INDIAN J TRADIT KNOW
JI Indian J. Tradit. Knowl.
PD JUL
PY 2015
VL 14
IS 3
BP 461
EP 465
PG 5
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA CT0EZ
UT WOS:000362468000020
DA 2025-06-11
ER

PT J
AU Kase, NG
   Friedman, EG
   Brodman, M
   Kang, CF
   Gallagher, EJ
   LeRoith, D
AF Kase, Nathan G.
   Friedman, Elissa Gretz
   Brodman, Michael
   Kang, Chifei
   Gallagher, Emily J.
   LeRoith, Derek
TI The midlife transition and the risk of cardiovascular disease and cancer
   Part I: magnitude and mechanisms
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Review
DE aging; cancer; coronary artery disease; diabetes type 2; dyslipidemia;
   estradiol; hormone therapy; insulin resistance; menopause; midlife
   transition; metabolic syndrome; steroid and insulin receptors; systemic
   inflammatory state; visceral adiposity; waist circumference; window of
   opportunity
ID CORONARY-HEART-DISEASE; POSTMENOPAUSAL HORMONE-THERAPY; ESTROGEN PLUS
   PROGESTIN; BODY-MASS INDEX; BREAST-CANCER; WOMENS HEALTH; METABOLIC
   SYNDROME; DIABETES-MELLITUS; INSULIN-RECEPTOR; UNITED-STATES
AB Heart disease and cancer are the leading causes of death in the United States. In women, the clinical appearance of both entities-coronary heart disease and cancer (breast, endometrium, and ovary)-escalate during the decades of the midlife transition encompassing the menopause. In addition to the impact of aging, during the interval between the age of 40 and 65 years, the pathophysiologic components of metabolic syndrome also emerge and accelerate. These include visceral adiposity (measured as waist circumference), hypertension, diabetes, and dyslipidemia. Osteoporosis, osteoarthritis, sarcopenia, depression, and even cognitive decline and dementia appear, and most, if not all, are considered functionally related. Two clinical reports confirm the interaction linking the emergence of disease: endometrial cancer and metabolic syndrome. One describes the discovery of unsuspected endometrial cancer in a large series of elective hysterectomies performed in aged and metabolically susceptible populations. The other is from the Women's Health Initiative Observational Study, which found a positive interaction between endometrial cancer and metabolic syndrome regardless of the presence or absence of visceral adiposity. Both provide additional statistical support for the long-suspected causal interaction among the parallel but variable occurrence of these common entities-visceral obesity, heart disease, diabetes, cancer, and the prevalence of metabolic syndrome. Therefore, 2 critical clinical questions require analysis and answers:
   1: Why do chronic diseases of adulthood-metabolic, cardiovascular, endocrine- and, in women, cancers of the breast and endometrium (tissues and tumors replete with estrogen receptors) emerge and their incidence trajectories accelerate during the postmenopausal period when little or no endogenous estradiol is available, and yet the therapeutic application of estrogen stimulates their appearance?
   2: To what extent should identification of these etiologic driving forces require modification of the gynecologist's responsibilities in the care of our patients in the postreproductive decades of the female life cycle?
   Part I of this 2-part set of "expert reviews" defines the dimensions, gravity, and interactive synergy of each clinical challenge gynecologists face while caring for their midlife (primarily postmenopausal) patients. It describes the clinically identifiable, potentially treatable, pathogenic mechanisms driving these threats to quality of life and longevity.
   Part 2 (accepted, American Journal of Obstetrics & Gynecology) identifies 7 objectives of successful clinical care, offers "triage" prioritization targets, and provides feasible opportunities for insertion of primary preventive care initiatives. To implement these goals, a reprogrammed, repurposed office visit is described.YY
C1 [Kase, Nathan G.; Friedman, Elissa Gretz; Brodman, Michael] Icahn Sch Med Mt Sinai, Dept Obstet Gynecol & Reprod Sci, New York, NY 10029 USA.
   [Kase, Nathan G.; Kang, Chifei; Gallagher, Emily J.; LeRoith, Derek] Icahn Sch Med Mt Sinai, Dept Med, Div Endocrinol Diabet & Bone Dis, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at
   Mount Sinai
RP Kase, NG (corresponding author), Icahn Sch Med Mt Sinai, Dept Obstet Gynecol & Reprod Sci, New York, NY 10029 USA.; Kase, NG (corresponding author), Icahn Sch Med Mt Sinai, Dept Med, Div Endocrinol Diabet & Bone Dis, New York, NY 10029 USA.
EM nathan.kase@mssm.edu
CR ADASHI EY, 1994, FERTIL STERIL, V62, P20
   Afshin A, 2017, NEW ENGL J MED, V377, P13, DOI 10.1056/NEJMoa1614362
   Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Anderson GL, 2003, JAMA-J AM MED ASSOC, V290, P1739, DOI 10.1001/jama.290.13.1739
   [Anonymous], 2020, CANCER EPIDEM BIOMAR, DOI DOI 10.1158/1055-9965.EPI-19-0206
   Appiah D, 2014, DIABETES CARE, V37, P725, DOI 10.2337/dc13-1986
   Arthur RS, 2019, CANCER CAUSE CONTROL, V30, P355, DOI 10.1007/s10552-019-01139-5
   Avis NE, 2015, JAMA INTERN MED, V175, P531, DOI 10.1001/jamainternmed.2014.8063
   Baber RJ, 2016, CLIMACTERIC, V19, P109, DOI 10.3109/13697137.2015.1129166
   Balkwill F, 2005, CANCER CELL, V7, P211, DOI 10.1016/j.ccr.2005.02.013
   BARDIN CW, 1967, J CLIN INVEST, V46, P891, DOI 10.1172/JCI105588
   BarrettConnor E, 1997, CIRCULATION, V95, P252, DOI 10.1161/01.CIR.95.1.252
   Belfiore A, 2011, ENDOCR-RELAT CANCER, V18, pR125, DOI 10.1530/ERC-11-0074
   Ben QW, 2011, EUR J CANCER, V47, P1928, DOI 10.1016/j.ejca.2011.03.003
   Ben T, 2011, BREAST CANCER RES, V13, DOI 10.1186/bcr2904
   Berry JD, 2012, NEW ENGL J MED, V366, P321, DOI 10.1056/NEJMoa1012848
   Brand JS, 2013, DIABETES CARE, V36, P1012, DOI 10.2337/dc12-1020
   Brewer TM, 2013, BRIT J CANCER, V109, P318, DOI 10.1038/bjc.2013.342
   Bronsveld HK, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0170084
   Brunetti A, 2001, FASEB J, V15, P492, DOI 10.1096/fj.00-0190com
   Burger HG, 2000, J CLIN ENDOCR METAB, V85, P2832, DOI 10.1210/jc.85.8.2832
   Burren CP, 1999, J CLIN ENDOCR METAB, V84, P1096
   Calle EE, 2005, NEW ENGL J MED, V353, P2197, DOI 10.1056/NEJM200511173532020
   Calle EE, 2003, NEW ENGL J MED, V348, P1625, DOI 10.1056/NEJMoa021423
   Campbell PT, 2012, DIABETES CARE, V35, P1835, DOI 10.2337/dc12-0002
   Campisi J, 2019, NATURE, V571, P183, DOI 10.1038/s41586-019-1365-2
   Carey L, 2010, NAT REV CLIN ONCOL, V7, P683, DOI 10.1038/nrclinonc.2010.154
   Carr MC, 2003, J CLIN ENDOCR METAB, V88, P2404, DOI 10.1210/jc.2003-030242
   Chahil TJ, 2006, ENDOCRIN METAB CLIN, V35, P491, DOI 10.1016/j.ecl.2006.06.002
   Chen WY, 2006, ARCH INTERN MED, V166, P1027, DOI 10.1001/archinte.166.9.1027
   Chiefari E, 2013, SCI REP-UK, V3, DOI 10.1038/srep01491
   Chimento A, 2019, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00807
   Clarkson TB, 2009, AM J PRIMATOL, V71, P785, DOI 10.1002/ajp.20693
   Colditz GA, 2018, CLIN CHEM, V64, P154, DOI 10.1373/clinchem.2017.277376
   Compston J, 2005, BEST PRACT RES CL RH, V19, P1007, DOI 10.1016/j.berh.2005.06.010
   Cornel KMC, 2019, MOL CELL ENDOCRINOL, V489, P45, DOI 10.1016/j.mce.2018.10.004
   de Zambotti M, 2014, FERTIL STERIL, V102, P1708, DOI 10.1016/j.fertnstert.2014.08.016
   Deelen J, 2019, NAT COMMUN, V10, DOI [10.1038/s41467-019-11311-9, 10.1038/s41467-019-11558-2]
   Desai VB, 2019, AM J OBSTET GYNECOL, V221, P39
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   El Khoudary SR, 2019, MENOPAUSE, V26, P1213, DOI 10.1097/GME.0000000000001424
   Ervin R Bethene, 2009, Natl Health Stat Report, P1
   Espeland MA, 1998, DIABETES CARE, V21, P1589, DOI 10.2337/diacare.21.10.1589
   Feinberg AP, 2018, NEW ENGL J MED, V378, P1323, DOI [10.1056/NEJMra1402513, 10.1056/nejmra1402513]
   Fernández AM, 2001, GENE DEV, V15, P1926, DOI 10.1101/gad.908001
   Flegal KM, 2012, JAMA-J AM MED ASSOC, V307, P491, DOI 10.1001/jama.2012.39
   Freeman EW, 2014, MENOPAUSE, V21, P924, DOI [10.1097/gme.0000000000000196, 10.1097/GME.0000000000000196]
   Gallagher EJ, 2017, ONCOGENE, V36, P6462, DOI 10.1038/onc.2017.247
   Gallagher EJ, 2015, PHYSIOL REV, V95, P727, DOI 10.1152/physrev.00030.2014
   Gallagher EJ, 2011, MED CLIN N AM, V95, P855, DOI 10.1016/j.mcna.2011.06.001
   Gallagher EJ, 2010, TRENDS ENDOCRIN MET, V21, P610, DOI 10.1016/j.tem.2010.06.007
   Go AS, 2014, CIRCULATION, V129, pE28, DOI 10.1161/01.cir.0000441139.02102.80
   Gold EB, 2001, AM J EPIDEMIOL, V153, P865, DOI 10.1093/aje/153.9.865
   Goodwin PJ, 2015, ANNU REV MED, V66, P281, DOI 10.1146/annurev-med-051613-012328
   GORDON T, 1978, ANN INTERN MED, V89, P157, DOI 10.7326/0003-4819-89-2-157
   GRADY D, 1992, ANN INTERN MED, V117, P1016, DOI 10.7326/0003-4819-117-12-1016
   Grumbach MM, 1999, J CLIN ENDOCR METAB, V84, P4677, DOI 10.1210/jc.84.12.4677
   Handelsman Y, 2013, ENDOCR PRACT, V19, P675, DOI 10.4158/EP13248.CS
   Harding JL, 2015, DIABETES CARE, V38, P734, DOI [10.2337/dc15-er04a, 10.2337/dc14-1996]
   Harrington SC, 2012, GROWTH HORM IGF RES, V22, P108, DOI 10.1016/j.ghir.2012.04.001
   Heiden MGV, 2009, SCIENCE, V324, P1029, DOI 10.1126/science.1160809
   Henley SJ, 2018, MMWR-MORBID MORTAL W, V67, P1333, DOI 10.15585/mmwr.mm6748a1
   Hsia J, 2006, ARCH INTERN MED, V166, P357, DOI 10.1001/archinte.166.3.357
   Hwa V, 1999, ENDOCR REV, V20, P761, DOI 10.1210/er.20.6.761
   Jaakkola S, 2009, OBSTET GYNECOL, V114, P1197, DOI 10.1097/AOG.0b013e3181bea950
   Johnell O, 2005, OSTEOPOROSIS INT, V16, pS3, DOI 10.1007/s00198-004-1702-6
   Kanaya AM, 2003, ANN INTERN MED, V138, P1, DOI 10.7326/0003-4819-138-1-200301070-00005
   Kang CF, 2018, ENDOCRINOLOGY, V159, P3801, DOI 10.1210/en.2018-00574
   KANNEL WB, 1976, ANN INTERN MED, V85, P447, DOI 10.7326/0003-4819-85-4-447
   Kase NG, 2013, ALTCHEK'S DIAGNOSIS AND MANAGEMENT OF OVARIAN DISORDERS, 3RD EDITION, P287
   Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213
   Labrie F, 2015, J STEROID BIOCHEM, V145, P133, DOI 10.1016/j.jsbmb.2014.06.001
   Larsson SC, 2007, INT J CANCER, V121, P856, DOI 10.1002/ijc.22717
   Law JH, 2008, CANCER RES, V68, P10238, DOI 10.1158/0008-5472.CAN-08-2755
   Lazar MA, 2006, NAT MED, V12, P43, DOI 10.1038/nm0106-43
   LeBlanc ES, 2017, MENOPAUSE, V24, P64, DOI 10.1097/GME.0000000000000714
   Lee CG, 2009, J CLIN ENDOCR METAB, V94, P1104, DOI 10.1210/jc.2008-0701
   Llaverias G, 2011, AM J PATHOL, V178, P402, DOI 10.1016/j.ajpath.2010.11.005
   Lobo R, 2016, COMPREHENSIVE GYNECO, V7th, P968
   LONGCOPE C, 1981, MATURITAS, V3, P215, DOI 10.1016/0378-5122(81)90028-1
   Looker AC, 2017, NATL HLTH STAT REPOR, V103
   Lovejoy JC, 2008, INT J OBESITY, V32, P949, DOI 10.1038/ijo.2008.25
   Malacara JM, 1997, MATURITAS, V28, P35, DOI 10.1016/S0378-5122(97)00051-0
   Manson JE, 2017, JAMA-J AM MED ASSOC, V318, P927, DOI 10.1001/jama.2017.11217
   Manson JE, 2013, JAMA-J AM MED ASSOC, V310, P1353, DOI 10.1001/jama.2013.278040
   Mantovani A, 2008, NATURE, V454, P436, DOI 10.1038/nature07205
   Margolis KL, 2004, DIABETOLOGIA, V47, P1175, DOI 10.1007/s00125-004-1448-x
   Marwarha G, 2017, CHEM PHYS LIPIDS, V207, P108, DOI 10.1016/j.chemphyslip.2017.05.012
   Matthews KA, 2009, J AM COLL CARDIOL, V54, P2366, DOI 10.1016/j.jacc.2009.10.009
   Mauvais-Jarvis F, 2017, ENDOCR REV, V38, P173, DOI 10.1210/er.2016-1146
   Melvin JC, 2013, J CANCER EPIDEMIOL, V2013, DOI 10.1155/2013/823849
   Mendelsohn ME, 2005, SCIENCE, V308, P1583, DOI 10.1126/science.1112062
   Mendelsohn ME, 1999, NEW ENGL J MED, V340, P1801, DOI 10.1056/NEJM199906103402306
   Menke A, 2015, JAMA-J AM MED ASSOC, V314, P1021, DOI 10.1001/jama.2015.10029
   Merhi Z, 2014, J CLIN ENDOCR METAB, V99, P1146, DOI 10.1210/jc.2013-4465
   Michalak EM, 2019, NAT REV MOL CELL BIO, V20, P573, DOI 10.1038/s41580-019-0143-1
   Nelson ER, 2013, SCIENCE, V342, P1094, DOI 10.1126/science.1241908
   Nielsen SF, 2012, NEW ENGL J MED, V367, P1792, DOI 10.1056/NEJMoa1201735
   Novosyadlyy R, 2010, CANCER RES, V70, P741, DOI 10.1158/0008-5472.CAN-09-2141
   Ogden CL, 2014, JAMA-J AM MED ASSOC, V311, P806, DOI 10.1001/jama.2014.732
   Olefsky JM, 2010, ANNU REV PHYSIOL, V72, P219, DOI 10.1146/annurev-physiol-021909-135846
   Ouchi N, 2011, NAT REV IMMUNOL, V11, P85, DOI 10.1038/nri2921
   Park SK, 2017, DIABETIC MED, V34, P531, DOI 10.1111/dme.13301
   Protani M, 2010, BREAST CANCER RES TR, V123, P627, DOI 10.1007/s10549-010-0990-0
   Reeves GK, 2007, BRIT MED J, V335, P1134, DOI 10.1136/bmj.39367.495995.AE
   Resar LMS, 2010, CANCER RES, V70, P436, DOI 10.1158/0008-5472.CAN-09-1212
   Rossouw JE, 2007, JAMA-J AM MED ASSOC, V297, P1465, DOI 10.1001/jama.297.13.1465
   Salpeter SR, 2006, DIABETES OBES METAB, V8, P538, DOI 10.1111/j.1463-1326.2005.00545.x
   Santen RJ, 2010, J CLIN ENDOCR METAB, V95, pS7, DOI 10.1210/jc.2009-2509
   Saul SR, 2019, ANN NY ACAD SCI, V1440, P5, DOI 10.1111/nyas.13952
   Shah SN, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0063419
   Shifren JL, 2019, JAMA-J AM MED ASSOC, V321, P2458, DOI 10.1001/jama.2019.5346
   Shulman GI, 2014, NEW ENGL J MED, V371, P2237
   Siegel RL, 2017, CA-CANCER J CLIN, V67, P7, DOI 10.3322/caac.21387
   Simigdala N, 2016, BREAST CANCER RES, V18, DOI 10.1186/s13058-016-0713-5
   Simons K, 2000, SCIENCE, V290, P1721, DOI 10.1126/science.290.5497.1721
   Simpson ER, 2005, ENDOCR REV, V26, P322, DOI 10.1210/er.2004-0020
   Simpson ER, 2003, J STEROID BIOCHEM, V86, P225, DOI 10.1016/S0960-0760(03)00360-1
   Simpson ER, 2013, MOL ENDOCRINOL, V27, P715, DOI 10.1210/me.2013-1011
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Surmacz E, 2013, J MAMMARY GLAND BIOL, V18, P321, DOI 10.1007/s10911-013-9302-8
   Taniguchi CM, 2006, NAT REV MOL CELL BIO, V7, P85, DOI 10.1038/nrm1837
   Taubes G, 2009, SCIENCE, V325, P256, DOI 10.1126/science.325_256
   Taylor F, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004816.pub5
   Thurston RC, 2018, MENOPAUSE, V25, P849, DOI 10.1097/GME.0000000000001143
   Tirosh A, 2011, NEW ENGL J MED, V364, P1315, DOI 10.1056/NEJMoa1006992
   United States Department of Commerce United States Census Bureau, 2010, THE OLDER POPULATION
   Van Wyhe RD, 2017, BREAST CANCER-TARGET, V9, P559, DOI 10.2147/BCTT.S148080
   vanderSchouw YT, 1996, LANCET, V347, P714, DOI 10.1016/S0140-6736(96)90075-6
   Wang CG, 2012, INT J CANCER, V130, P1639, DOI 10.1002/ijc.26165
   Ward CW, 2009, BIOESSAYS, V31, P422, DOI 10.1002/bies.200800210
   White MF, 1998, MOL CELL BIOCHEM, V182, P3, DOI 10.1023/A:1006806722619
   Wild RA, 2013, MENOPAUSE, V20, P254, DOI [10.1097/gme.0b013e31826f80e0, 10.1097/GME.0b013e31826f80e0]
   Woods Nancy Fugate, 2005, Am J Med, V118 Suppl 12B, P14
   Xu Jiaquan, 2016, NCHS Data Brief, P1
NR 136
TC 16
Z9 17
U1 1
U2 13
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
EI 1097-6868
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD DEC
PY 2020
VL 223
IS 6
BP 820
EP 833
DI 10.1016/j.ajog.2020.05.051
PG 14
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA PL4EX
UT WOS:000603078300017
PM 32497614
DA 2025-06-11
ER

PT J
AU Leu, S
   Wu, KLH
   Lee, WC
   Tain, YL
   Chan, JYH
AF Leu, Steve
   Wu, Kay L. H.
   Lee, Wei-Chia
   Tain, You-Lin
   Chan, Julie Y. H.
TI Maternal Fructose Intake Exacerbates Cardiac Remodeling in Offspring
   with Ventricular Pressure Overload
SO NUTRIENTS
LA English
DT Article
DE maternal fructose exposure; developmental programming; cardiac
   hypertrophy; oxidative stress; transverse aortic constriction
ID NUTRIENT RESTRICTION; INSULIN-RESISTANCE; METABOLIC SYNDROME; DIETARY
   FRUCTOSE; OXIDATIVE STRESS; HYPERTROPHY; HYPERTENSION; OBESITY;
   EXPRESSION; RECEPTORS
AB Recent studies demonstrated that metabolic syndrome and cardiovascular diseases could be elicited by developmental programming, which is regulated by prenatal nutritional and environmental stress. In this study, we utilized a rat model to examine the effect of excessive maternal fructose intake during pregnancy and lactation on cardiac development and progression of pressure overload-induced cardiac hypertrophy in offspring. Transverse aortic constriction (TAC) was performed on 3-month-old male offspring to induce ventricular pressure overload. Four weeks post-TAC, echocardiographic assessment as well as histopathological and biochemical examinations were performed on the myocardium of the offspring. Echocardiographic and gross examinations showed that heart weight, interventricular septal thickness in diastole (IVD; d), and left ventricular posterior wall thickness in diastole (LVPW; d) were elevated in offspring with TAC and further increased by maternal fructose exposure (MFE). However, the left ventricular ejection function was not significantly affected. Myocardial histopathological examination revealed that the indices of fibrosis and oxidative stress were higher in offspring with MFE and TAC than those in animals receiving either treatment. Molecular examinations on the myocardium demonstrated an MFE-induced upregulation of p38-MAPK signaling. Next generation sequence (NGS) analysis indicated a modulation of the expression levels of several cardiac hypertrophy-associated genes, including GPR22, Myh7, Nppa, P2RX4, and Npy by MFE. Subsequent RT-PCR indicated that MFE regulated the expression levels of genes responsive to cardiac hypertrophy (i.e., Myh-7, ANP) and oxidative stress (i.e., GR, GPx, and NQO-1). In conclusion, MFE during pregnancy and lactation modulated myocardial gene expression, increased oxidative stress, and exacerbated ventricular pressure overload-induced cardiac remodeling in rat offspring.
C1 [Leu, Steve; Wu, Kay L. H.; Tain, You-Lin; Chan, Julie Y. H.] Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 833401, Taiwan.
   [Leu, Steve] Kaohsiung Med Univ, Dept Biotechnol, Coll Life Sci, Kaohsiung 807378, Taiwan.
   [Lee, Wei-Chia] Chang Gung Univ, Dept Urol, Kaohsiung Chang Gung Mem Hosp, Kaohsiung 833401, Taiwan.
   [Lee, Wei-Chia; Tain, You-Lin] Chang Gung Univ, Coll Med, Kaohsiung 833401, Taiwan.
   [Tain, You-Lin] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Kaohsiung 833401, Taiwan.
C3 Chang Gung Memorial Hospital; Kaohsiung Medical University; Chang Gung
   Memorial Hospital; Chang Gung Memorial Hospital
RP Leu, S; Chan, JYH (corresponding author), Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 833401, Taiwan.
EM leu@mail.cgu.edu.tw; wlh0701@yahoo.com.tw; dinor666@ms32.hinet.net;
   tainyl@hotmail.com; jchan@adm.cgmh.org.tw
RI Wu, Kay/ACD-1767-2022; Chan, Julie/X-5253-2019; Tain,
   You-Lin/H-2827-2019; Leu, Steve/D-6807-2011
OI Chan, Julie Y.H./0000-0001-8036-4645; Tain, You-Lin/0000-0002-7059-6407;
   Lee, Wei-Chia/0000-0003-0701-2285; Leu, Steve/0000-0002-1738-1028; Wu,
   Kay L.H./0000-0002-7297-6788
FU Chang Gung Medical Research Program Grant [CMRPG 8F0041, 8F0042,
   8F0043]; Ministry of Science and Technology, Taiwan [MOST
   109-2320-B-182A-009]
FX This research was Chang Gung Medical Research Program Grant (Grant
   number: CMRPG 8F0041, 8F0042, 8F0043) and from Ministry of Science and
   Technology, Taiwan (MOST 109-2320-B-182A-009).
CR Adams JW, 2008, AM J PHYSIOL-HEART C, V295, pH509, DOI 10.1152/ajpheart.00368.2008
   Bae S, 2003, AM J PHYSIOL-HEART C, V285, pH983, DOI 10.1152/ajpheart.00005.2003
   Bantle JP, 2009, J NUTR, V139, pS1263, DOI 10.3945/jn.108.098020
   Battista MC, 2005, J PHYSIOL-LONDON, V565, P197, DOI 10.1113/jphysiol.2004.078139
   Boulanger CM, 1999, J MOL CELL CARDIOL, V31, P39, DOI 10.1006/jmcc.1998.0842
   Bray GA, 2004, AM J CLIN NUTR, V79, P537
   Braz JC, 2003, J CLIN INVEST, V111, P1475, DOI 10.1172/JCI200317295
   Cox EJ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0092903
   Deng JY, 2007, AM J PHYSIOL-HEART C, V293, pH978, DOI 10.1152/ajpheart.01002.2006
   Dong ML, 2013, J MOL CELL CARDIOL, V55, P111, DOI 10.1016/j.yjmcc.2012.08.023
   Elliott SS, 2002, AM J CLIN NUTR, V76, P911, DOI 10.1093/ajcn/76.5.911
   Elshenawy S, 2016, MOL CELL ENDOCRINOL, V435, P2, DOI 10.1016/j.mce.2016.07.002
   Han HC, 2004, J PHYSIOL-LONDON, V558, P111, DOI 10.1113/jphysiol.2004.061697
   Huang Y, 2010, AM J PHYSIOL-ENDOC M, V299, pE968, DOI 10.1152/ajpendo.00434.2010
   HWANG IS, 1987, HYPERTENSION, V10, P512, DOI 10.1161/01.HYP.10.5.512
   Iliev A, 2019, ACTA HISTOCHEM, V121, P16, DOI 10.1016/j.acthis.2018.10.004
   Leu S, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20102429
   Li GH, 2003, J SOC GYNECOL INVEST, V10, P265, DOI 10.1016/S1071-5576(03)00074-1
   Liang QR, 2003, J MOL CELL CARDIOL, V35, P1385, DOI 10.1016/j.yjmcc.2003.10.001
   LUCAS A, 1991, CIBA F SYMP, V156, P38
   McDermott BJ, 2007, CURR TOP MED CHEM, V7, P1692, DOI 10.2174/156802607782340939
   Miller A, 2008, CURR OPIN GASTROEN, V24, P204, DOI 10.1097/MOG.0b013e3282f3f4c4
   Park JH, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-27788-1
   Rababa'h AM, 2018, CURR CARDIOL REV, V14, P53, DOI 10.2174/1573403X14666180111145207
   Ruiz-Hernández A, 2015, J RECEPT SIG TRANSD, V35, P46, DOI 10.3109/10799893.2014.926926
   Sanchez-Lozada LG, 2007, AM J PHYSIOL-RENAL, V292, pF423, DOI 10.1152/ajprenal.00124.2006
   Satoh K, 2010, ANTIOXID REDOX SIGN, V12, P675, DOI 10.1089/ars.2009.2875
   Tain YL, 2015, J NUTR BIOCHEM, V26, P642, DOI 10.1016/j.jnutbio.2014.12.017
   Tain YL, 2014, J PINEAL RES, V57, P80, DOI 10.1111/jpi.12145
   Tappy L, 2010, NUTRITION, V26, P1044, DOI 10.1016/j.nut.2010.02.014
   Wang JH, 2021, INT J MED SCI, V18, P18, DOI 10.7150/ijms.51133
   Wang JY, 2010, FASEB J, V24, P2066, DOI 10.1096/fj.09-142315
   Williams SJ, 2005, AM J PHYSIOL-REG I, V288, pR360, DOI 10.1152/ajpregu.00178.2004
   Xie YX, 2020, PROTEIN PEPTIDE LETT, V27, P878, DOI 10.2174/0929866527666200416144459
   Yang A, 2004, AM J PHYSIOL-HEART C, V287, pH1096, DOI 10.1152/ajpheart.00079.2004
   Yang FMY, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0040196
   Yildiz M, 2020, PROG CARDIOVASC DIS, V63, P10, DOI 10.1016/j.pcad.2019.11.009
   Zhang SS, 2003, J CLIN INVEST, V111, P833, DOI 10.1172/JCI200316290
   Zhang YB, 2016, AM J TRANSL RES, V8, P4869
NR 39
TC 5
Z9 5
U1 1
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2021
VL 13
IS 9
AR 3267
DI 10.3390/nu13093267
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA UY6JG
UT WOS:000701627300001
PM 34579143
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Harman-Boehm, I
AF Harman-Boehm, I
TI The patient with unstable angina: no evidence of MI
SO ACTA DIABETOLOGICA
LA English
DT Article
DE diabetes mellitus; ischemic heart disease; angina pectoris
AB A 53-year-old type 2 diabetic woman with macrovascular complications as well as the components of the metabolic syndrome presents with an unstable angina and ST depression on electromiogram. The negative impact of female gender, microvascular complications, and metabolic parameters on cardiovascular risk and prognosis, are emphasized. The lack of evidence for hormone replacement, antioxidant or universal folic acid therapy is underscored. Treatment options including PTCA and stenting augmented with low molecular weight heparin, clopidrogel and IIb/IIIa antagonists as well as optimal metabolic control are discussed.
C1 Soroka Hosp, Beer Sheva, Israel.
C3 Ben-Gurion University of the Negev; Soroka Medical Center
RP Harman-Boehm, I (corresponding author), Soroka Hosp, Beer Sheva, Israel.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER-VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010 USA
SN 0940-5429
J9 ACTA DIABETOL
JI Acta Diabetol.
PD DEC
PY 2003
VL 40
SU 2
BP S407
EP S408
DI 10.1007/s00592-003-0128-5
PG 2
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 758HP
UT WOS:000187628600017
PM 14704877
DA 2025-06-11
ER

PT J
AU Walker, BR
   Seckl, JR
AF Walker, BR
   Seckl, JR
TI 11β-hydroxysteroid dehydrogenase Type 1 as a novel therapeutic target in
   metabolic and neurodegenerative disease
SO EXPERT OPINION ON THERAPEUTIC TARGETS
LA English
DT Review
DE 11 beta-hydroxysteroid dehydrogenase Type I (11HSD1); cognitive
   impairment no dementia; glucocordcoids; hypertension; metabolic syndrome
ID BETA-HYDROXYSTEROID DEHYDROGENASE; GUINEA-PIG KIDNEY; SELECTIVE
   GLUCOCORTICOID MODULATORS; CORTISONE REDUCTASE DEFICIENCY; HEPATIC
   INSULIN SENSITIVITY; MESSENGER-RIBONUCLEIC-ACID; ADIPOSE STROMAL CELLS;
   BODY-FAT DISTRIBUTION; CARDIOVASCULAR RISK; BLOOD-PRESSURE
AB 11beta-Hydroxysteroid dehydrogenase Type 1 (11HSD1) catalyses regeneration of active 11-hydroxy glucocorticoids from inactive 11-keto metabolites within target tissues. Inhibition of 11HSD1 has been proposed as a novel strategy to lower intracellular glucocorticoid concentrations, without affecting circulating glucocorticoid levels and their responsiveness to stress. Increased 11HSD1 activity may be pathogenic, for example, in adipose tissue in obesity. Experiments in transgenic mice and using prototype inhibitors in humans show benefits of 11HSD1 inhibition in liver, adipose and brain tissue in treating features of the metabolic syndrome and cognitive dysfunction with ageing. The clinical development of potent selective 11HSD1 inhibitors is now a high priority.
C1 Univ Edinburgh, Western Gen Hosp, Endocrinol Unit, Edinburgh EH4 2XU, Midlothian, Scotland.
C3 University of Edinburgh
RP Univ Edinburgh, Western Gen Hosp, Endocrinol Unit, Edinburgh EH4 2XU, Midlothian, Scotland.
EM B.Walker@ed.ac.uk
CR AGARWAL AK, 1994, J BIOL CHEM, V269, P25959
   AGARWAL AK, 1989, J BIOL CHEM, V264, P18939
   Alberts P, 2002, DIABETOLOGIA, V45, P1528, DOI 10.1007/s00125-002-0959-6
   ALBISTON AL, 1994, MOL CELL ENDOCRINOL, V105, pR11, DOI 10.1016/0303-7207(94)90176-7
   Andrew R, 1998, J CLIN ENDOCR METAB, V83, P1806, DOI 10.1210/jc.83.5.1806
   Andrews RC, 2002, J CLIN ENDOCR METAB, V87, P5587, DOI 10.1210/jc.2002-020048
   Andrews RC, 2003, J CLIN ENDOCR METAB, V88, P285, DOI 10.1210/jc.2002-021194
   Barf T, 2002, J MED CHEM, V45, P3813, DOI 10.1021/jm025530f
   Björntorp P, 1999, DIABETIC MED, V16, P373, DOI 10.1046/j.1464-5491.1999.00067.x
   Brem AS, 1997, HYPERTENSION, V30, P449, DOI 10.1161/01.HYP.30.3.449
   Brown RW, 1996, ENDOCRINOLOGY, V137, P794, DOI 10.1210/en.137.2.794
   BUHLER H, 1991, BIOCHIM BIOPHYS ACTA, V1075, P206, DOI 10.1016/0304-4165(91)90268-L
   Bujalska IJ, 1999, ENDOCRINOLOGY, V140, P3188, DOI 10.1210/en.140.7.3188
   Bujalska IJ, 2002, J CLIN ENDOCR METAB, V87, P1205, DOI 10.1210/jc.87.3.1205
   Bujalska IJ, 1997, LANCET, V349, P1210, DOI 10.1016/S0140-6736(96)11222-8
   Cai TQ, 2001, J STEROID BIOCHEM, V77, P117, DOI 10.1016/S0960-0760(01)00041-3
   Chaytor AT, 2000, ENDOTHELIUM-NEW YORK, V7, P265, DOI 10.3109/10623320009072213
   Christy C, 2003, HYPERTENSION, V42, P580, DOI 10.1161/01.HYP.0000088855.06598.5B
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Coghlan MJ, 2003, MOL ENDOCRINOL, V17, P860, DOI 10.1210/me.2002-0355
   Colao A, 1999, J CLIN ENDOCR METAB, V84, P2664, DOI 10.1210/jc.84.8.2664
   Coleman HA, 2001, J PHYSIOL-LONDON, V531, P359, DOI 10.1111/j.1469-7793.2001.0359i.x
   Cooper MS, 2001, J BONE MINER RES, V16, P1037, DOI 10.1359/jbmr.2001.16.6.1037
   Cooper MS, 2002, J BONE MINER RES, V17, P979, DOI 10.1359/jbmr.2002.17.6.979
   Draper N, 2003, NAT GENET, V34, P434, DOI 10.1038/ng1214
   Draper N, 2002, J CLIN ENDOCR METAB, V87, P4984, DOI 10.1210/jc.2001-011375
   Edgerton D, 2003, DIABETES, V52, pA118
   Elmore SW, 2001, J MED CHEM, V44, P4481, DOI 10.1021/jm010367u
   ESCHER G, 1995, ENDOCRINOLOGY, V136, P1759, DOI 10.1210/en.136.4.1759
   Escher G, 1998, GASTROENTEROLOGY, V114, P175, DOI 10.1016/S0016-5085(98)70645-6
   ETXABE J, 1994, CLIN ENDOCRINOL, V40, P479, DOI 10.1111/j.1365-2265.1994.tb02486.x
   Evagelatou M, 1997, MOL CELL ENDOCRINOL, V133, P81, DOI 10.1016/S0303-7207(97)00146-9
   Filipovsky J, 1996, J HYPERTENS, V14, P229, DOI 10.1097/00004872-199602000-00012
   Fraser R, 1999, HYPERTENSION, V33, P1364, DOI 10.1161/01.HYP.33.6.1364
   Fuster D, 1998, ENDOCRINOLOGY, V139, P3849, DOI 10.1210/en.139.9.3849
   GAILLARD RC, 1985, J CLIN ENDOCR METAB, V61, P1009, DOI 10.1210/jcem-61-6-1009
   Goto K, 2002, CLIN EXP PHARMACOL P, V29, P595, DOI 10.1046/j.1440-1681.2002.03689.x
   Hadoke PWF, 2001, CIRCULATION, V104, P2832, DOI 10.1161/hc4801.100077
   Harris HJ, 2001, ENDOCRINOLOGY, V142, P114, DOI 10.1210/en.142.1.114
   HOMMA M, 1995, J PHARM PHARMACOL, V47, P687, DOI 10.1111/j.2042-7158.1995.tb05861.x
   HOMMA M, 1994, J PHARM PHARMACOL, V46, P305, DOI 10.1111/j.2042-7158.1994.tb03799.x
   Hundertmark S, 2002, HORM METAB RES, V34, P537, DOI 10.1055/s-2002-35424
   Hundertmark S, 2002, HORM METAB RES, V34, P545, DOI 10.1055/s-2002-35425
   Jamieson A, 1999, J CLIN ENDOCR METAB, V84, P3570, DOI 10.1210/jc.84.10.3570
   Jamieson PM, 2000, J ENDOCRINOL, V165, P685, DOI 10.1677/joe.0.1650685
   JAMIESON PM, 1995, ENDOCRINOLOGY, V136, P4754, DOI 10.1210/en.136.11.4754
   JELLINCK PH, 1993, J STEROID BIOCHEM, V46, P209, DOI 10.1016/0960-0760(93)90296-9
   KATO H, 1995, J CLIN ENDOCR METAB, V80, P1929, DOI 10.1210/jc.80.6.1929
   Katz JR, 1999, CLIN ENDOCRINOL, V50, P63, DOI 10.1046/j.1365-2265.1999.00598.x
   Kenny LC, 2002, BRIT J PHARMACOL, V136, P1085, DOI 10.1038/sj.bjp.0704817
   Kotelevtsev Y, 1997, P NATL ACAD SCI USA, V94, P14924, DOI 10.1073/pnas.94.26.14924
   Kotelevtsev Y, 1999, J CLIN INVEST, V103, P683, DOI 10.1172/JCI4445
   Kym PR, 2003, J MED CHEM, V46, P1016, DOI 10.1021/jm020335m
   LATIF S A, 1990, Steroids, V55, P52, DOI 10.1016/0039-128X(90)90024-6
   Latif SA, 1997, STEROIDS, V62, P230, DOI 10.1016/S0039-128X(96)00208-5
   LATIF SA, 1994, STEROIDS, V59, P352, DOI 10.1016/0039-128X(94)90001-9
   Lee YS, 1996, CLIN PHARMACOL THER, V59, P62, DOI 10.1016/S0009-9236(96)90025-9
   Lindsay RS, 2003, J CLIN ENDOCR METAB, V88, P2738, DOI 10.1210/jc.2002-030017
   Liu YJ, 2003, DIABETES, V52, P1409, DOI 10.2337/diabetes.52.6.1409
   Livingstone DEW, 2003, J PHARMACOL EXP THER, V305, P167, DOI 10.1124/jpet.102.044842
   Livingstone DEW, 2000, ENDOCRINOLOGY, V141, P560, DOI 10.1210/en.141.2.560
   Ljung T, 1996, OBES RES, V4, P277, DOI 10.1002/j.1550-8528.1996.tb00546.x
   Lottenberg SA, 1998, INT J CLIN PHARM TH, V36, P501
   LOW SC, 1994, J MOL ENDOCRINOL, V13, P167, DOI 10.1677/jme.0.0130167
   Lupien SJ, 1998, NAT NEUROSCI, V1, P69, DOI 10.1038/271
   Maser E, 2002, BIOCHEMISTRY-US, V41, P2459, DOI 10.1021/bi015803t
   Masuzaki H, 2003, J CLIN INVEST, V112, P83, DOI [10.1172/JCI200317845, 10.1172/JCI17845]
   Masuzaki H, 2001, SCIENCE, V294, P2166, DOI 10.1126/science.1066285
   MONDER C, 1989, ENDOCRINOLOGY, V125, P1046, DOI 10.1210/endo-125-2-1046
   Morita H, 1996, ENDOCRINOLOGY, V137, P2308, DOI 10.1210/en.137.6.2308
   MORRIS DJ, 1992, HYPERTENSION, V20, P356, DOI 10.1161/01.HYP.20.3.356
   Morton NM, 2001, J BIOL CHEM, V276, P41293, DOI 10.1074/jbc.M103676200
   MORTON NM, 2002, P END 2002
   Palermo M, 2003, CLIN ENDOCRINOL, V59, P143, DOI 10.1046/j.1365-2265.2003.01806.x
   Palermo M, 2002, EXP CLIN ENDOCR DIAB, V110, P272, DOI 10.1055/s-2002-34589
   PATERSON JM, 2003, P END 2003
   PATERSON JM, 2002, P END 2002
   Paulmyer-Lacroix O, 2002, J CLIN ENDOCR METAB, V87, P2701, DOI 10.1210/jc.87.6.2701
   PERSCHEL FH, 1991, PFLUG ARCH EUR J PHY, V418, P538, DOI 10.1007/BF00370568
   Phillipov G, 1996, J CLIN ENDOCR METAB, V81, P3855, DOI 10.1210/jc.81.11.3855
   PHILLIPS DM, 1989, ENDOCRINOLOGY, V125, P209, DOI 10.1210/endo-125-1-209
   Rabbitt EH, 2002, FASEB J, V16, P36, DOI 10.1096/fj.01-0582com
   Rajan V, 1996, J NEUROSCI, V16, P65
   Rask E, 2001, J CLIN ENDOCR METAB, V86, P1418, DOI 10.1210/jc.86.3.1418
   Rask E, 2002, J CLIN ENDOCR METAB, V87, P3330, DOI 10.1210/jc.87.7.3330
   RAVEN PW, 1995, CLIN ENDOCRINOL, V43, P637, DOI 10.1111/j.1365-2265.1995.tb02930.x
   Reus VI, 2001, EXPERT OPIN INV DRUG, V10, P1789, DOI 10.1517/13543784.10.10.1789
   Reynolds RM, 2001, J CLIN ENDOCR METAB, V86, P245, DOI 10.1210/jc.86.1.245
   Ritchie K, 2000, LANCET, V355, P225, DOI 10.1016/S0140-6736(99)06155-3
   Roseboom TJ, 1999, J HYPERTENS, V17, P325, DOI 10.1097/00004872-199917030-00004
   Rosmond R, 1998, J CLIN ENDOCR METAB, V83, P1853, DOI 10.1210/jc.83.6.1853
   SampathKumar R, 1997, J STEROID BIOCHEM, V62, P195, DOI 10.1016/S0960-0760(97)00027-7
   SANDEEP TC, 2002, AND ABSTR, V3
   Seckl JR, 2001, ENDOCRINOLOGY, V142, P1371, DOI 10.1210/en.142.4.1371
   SECKL JR, 2001, BAILLIERES BEST PRAC
   SEMAFUKO WEB, 1993, ANN CLIN LAB SCI, V23, P456
   Shafqat N, 2003, J BIOL CHEM, V278, P2030, DOI 10.1074/jbc.M210135200
   Shimoyama Y, 2003, J PHARM PHARMACOL, V55, P811, DOI 10.1211/002235703765951429
   SONG DJ, 1992, J LAB CLIN MED, V120, P792
   SOUNESS GW, 1995, ENDOCRINOLOGY, V136, P1809, DOI 10.1210/en.136.4.1809
   Stauffer AT, 2002, J BIOL CHEM, V277, P26286, DOI 10.1074/jbc.M201556200
   Stewart PM, 1999, VITAM HORM, V57, P249
   Stewart PM, 1999, J CLIN ENDOCR METAB, V84, P1022, DOI 10.1210/jc.84.3.1022
   STEWART PM, 1992, MOL CELL ENDOCRINOL, V83, pC13, DOI 10.1016/0303-7207(92)90149-Z
   STEWART PM, 1990, CLIN SCI, V78, P49, DOI 10.1042/cs0780049
   STEWART PM, 1987, LANCET, V2, P821
   STEWART PM, 1995, J CLIN ENDOCR METAB, V80, P885, DOI 10.1210/jc.80.3.885
   STRAIN GW, 1980, METABOLISM, V29, P980, DOI 10.1016/0026-0495(80)90043-8
   Takeda Y, 1996, HYPERTENSION, V27, P197, DOI 10.1161/01.HYP.27.2.197
   Tare M, 2002, AM J PHYSIOL-HEART C, V282, pH335, DOI 10.1152/ajpheart.2002.282.1.H335
   TEELUCKSINGH S, 1991, LANCET, V337, P1549, DOI 10.1016/0140-6736(91)93243-3
   Tetsuka M, 1999, J ENDOCRINOL, V163, P417, DOI 10.1677/joe.0.1630417
   Thieringer R, 2001, J IMMUNOL, V167, P30, DOI 10.4049/jimmunol.167.1.30
   Thomson LM, 1998, ENDOCR RES, V24, P607, DOI 10.3109/07435809809032654
   Thurston LM, 2003, BIOL REPROD, V68, P2157, DOI 10.1095/biolreprod.102.012096
   Tiosano D, 2003, J CLIN ENDOCR METAB, V88, P379, DOI 10.1210/jc.2002-020511
   Tomlinson JW, 2001, ENDOCRINOLOGY, V142, P1982, DOI 10.1210/en.142.5.1982
   Tomlinson JW, 2002, J CLIN ENDOCR METAB, V87, P5630, DOI 10.1210/jc.2002-020687
   Ullian ME, 1996, HYPERTENSION, V27, P1346, DOI 10.1161/01.HYP.27.6.1346
   Wake DJ, 2003, J CLIN ENDOCR METAB, V88, P3983, DOI 10.1210/jc.2003-030286
   Walker BR, 2000, J INTERN MED, V247, P198, DOI 10.1046/j.1365-2796.2000.00609.x
   Walker BR, 1998, HYPERTENSION, V31, P891, DOI 10.1161/01.HYP.31.4.891
   WALKER BR, 1995, J CLIN ENDOCR METAB, V80, P3155, DOI 10.1210/jc.80.11.3155
   WALKER BR, 1992, CLIN ENDOCRINOL, V37, P483, DOI 10.1111/j.1365-2265.1992.tb01478.x
   WALKER BR, 1995, HYPERTENSION, V25, P626, DOI 10.1161/01.HYP.25.4.626
   Walker BR, 2000, CLIN ENDOCRINOL, V52, P401, DOI 10.1046/j.1365-2265.2000.00969.x
   WALKER BR, 1995, J CLIN ENDOCR METAB, V80, P529, DOI 10.1210/jc.80.2.529
   Wang MS, 1997, ACTA PHARMACOL SIN, V18, P481
   Westerbacka J, 2003, J CLIN ENDOCR METAB, V88, P4924, DOI 10.1210/jc.2003-030596
   WILSON RC, 1995, J CLIN ENDOCR METAB, V80, P3145, DOI 10.1210/jc.80.11.3145
   Wolkowitz OM, 1999, BIOL PSYCHIAT, V45, P1070, DOI 10.1016/S0006-3223(98)00267-4
   Yang K, 1997, J STEROID BIOCHEM, V60, P247, DOI 10.1016/S0960-0760(96)00187-2
   Yau JLW, 2001, P NATL ACAD SCI USA, V98, P4716, DOI 10.1073/pnas.071562698
   Yong PYK, 2000, J CLIN ENDOCR METAB, V85, P4728, DOI 10.1210/jc.85.12.4728
   Zhang YD, 1997, ACTA PHARMACOL SIN, V18, P240
   ZHANG YD, 1994, J STEROID BIOCHEM, V49, P81, DOI 10.1016/0960-0760(94)90304-2
NR 136
TC 54
Z9 60
U1 0
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1472-8222
EI 1744-7631
J9 EXPERT OPIN THER TAR
JI Expert Opin. Ther. Targets
PD DEC
PY 2003
VL 7
IS 6
BP 771
EP 783
DI 10.1517/eott.7.6.771.22573
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 754LN
UT WOS:000187318800007
PM 14640912
DA 2025-06-11
ER

PT J
AU Roohafza, H
   Kabir, A
   Sadeghi, M
   Shokouh, P
   Aalaei-Andabili, SH
   Mehrabi, Y
   Sarrafzadegan, N
AF Roohafza, Hamidreza
   Kabir, Ali
   Sadeghi, Masoumeh
   Shokouh, Pedram
   Aalaei-Andabili, Seyed Hossein
   Mehrabi, Yadollah
   Sarrafzadegan, Nizal
TI Effect of Psychological Distress on Weight Concern and Weight Control
   Behaviors
SO ARCHIVES OF IRANIAN MEDICINE
LA English
DT Article
DE Iran; obesity; psychological distress; weight concern; weigh control
   behavior
ID STRESS-RELATED CHANGES; JOB STRAIN; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; BODY-MASS; OBESITY; PREVALENCE; ASSOCIATIONS;
   ADOLESCENTS; PERCEPTION
AB Background: Obesity is associated with chronic disorders like coronary artery diseases, metabolic syndrome, cancers, and psychiatric disorders. Stress may contribute to weight gain by disrupting weight concern, and lead to uncontrolled eating behavior. This study aimed to investigate the effects-of stress on weight concern-and control behaviour in normal Weight and obese adults.
   Methods: A total 9544-subjects were selected by multi-stage random sampling-from three provinces in central Iran. Information related to weight concern and control behavior was registered in normal weight and obese participants. Psychological distress was measured by a 12-item General Health Questionnaire (GHQ-12) and subjects were divided into high and low-stress groups. Logistic regression:was used for analysis.
   Results: The mean age of participants Was 38.7 +/- 15.5 years and 50% (4772) of them were males. The adjusted odds ratio (OR) for age, sex and education of high stress to low stress level for weight concern, weight Control behavior and acceptable physical activity behavior was more than 1; but the CA was less than 1 for waist circumference, obesity and,healthy diet-behavior. Among obese participants, higher levels of stress were associated with lower weight concern with OR, 95%Cl: 0.821, (0.682 +/- 0.988), lower acceptable physical-activity with OR = 0.833, 95%Cl: (0.624 +/- 0912), but higher rates of healthy diet behavior with OR = 1.360, 95% Cl: (1.040-1.780).
   Conclusion: Individuals with high stress level have lower weight concern and lower physical activity; therefore, they are probe to weight gain and obesity. It-could be concluded that stress management should be considered as a crucial component of obesity prevention and control programs.
C1 [Roohafza, Hamidreza] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Isfahan Cardiovasc Res Ctr, Dept Mental Hlth, Esfahan, Iran.
   [Kabir, Ali] Iran Univ Med Sci, Minimally Invas Surg Res Ctr, Tehran, Iran.
   [Kabir, Ali] Shahid Beheshti Univ Med Sci, Dept Epidemiol, Sch Publ Hlth, Tehran, Iran.
   [Sadeghi, Masoumeh] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Cardiac Rehabil Res Ctr, Esfahan, Iran.
   [Shokouh, Pedram] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Hypertens Res Ctr, Esfahan, Iran.
   [Aalaei-Andabili, Seyed Hossein] Nikan Hlth Researchers Inst, Tehran, Iran.
   [Mehrabi, Yadollah] Shahid Beheshti Univ Med Sci, Dept Epidemiol, Sch Publ Hlth, Tehran, Iran.
   [Sarrafzadegan, Nizal] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Isfahan Cardiovasc Res Ctr, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Iran University of Medical
   Sciences; Shahid Beheshti University Medical Sciences; Isfahan
   University of Medical Sciences; Isfahan University of Medical Sciences;
   Shahid Beheshti University Medical Sciences; Isfahan University of
   Medical Sciences
RP Sadeghi, M (corresponding author), Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Cardiac Rehabil Res Ctr, WHO Collaborating Ctr Res & Training Cardiovasc D, POB 81465-1148, Esfahan, Iran.
EM aikabir@yahoo.com; m_sadeghi@crc.mui.ac.ir
RI Kabir, A./M-5979-2016; Sadeghi, Masoumeh/W-2291-2017; Shokouh,
   Pedram/AAX-4572-2021; Sarrafzadegan, Nizal/V-5826-2017; Mehrabi,
   Yadollah/J-4211-2016; Mehrabi, Yadollah/J-4211-2016
OI Sadeghi Mahonak, Masoumeh/0000-0001-7179-5558; Roohafza,
   Hamidreza/0000-0003-3582-0431; Sarrafzadegan, Nizal/0000-0002-8352-0540;
   Mehrabi, Yadollah/0000-0001-9837-4956; Mehrabi,
   Yadollah/0000-0001-8555-6160
CR Ali SM, 2006, EUR J PUBLIC HEALTH, V16, P324, DOI 10.1093/eurpub/cki187
   Allen KL, 2006, INT J PEDIATR OBES, V1, P239, DOI 10.1080/17477160600913552
   [Anonymous], 2006, PREV CONTROL, DOI DOI 10.1016/J.PRECON.2006.10.003
   Ball K, 1999, WOMEN HEALTH, V29, P1, DOI 10.1300/J013v29n02_01
   Bhattacharyya M, 2013, PUBLIC HEALTH NUTR, P1
   Brandheim S, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-68
   Chan CWH, 2014, PSYCHO-ONCOLOGY, V23, P229, DOI 10.1002/pon.3396
   Cooper PJ, 1997, BRIT J PSYCHIAT, V171, P542, DOI 10.1192/bjp.171.6.542
   Cox TL, 2013, HEALTH EDUC BEHAV, V40, P78, DOI 10.1177/1090198112439411
   Deuschle M, 1997, J CLIN ENDOCR METAB, V82, P234, DOI 10.1210/jc.82.1.234
   GOLDBERG DP, 1979, PSYCHOL MED, V9, P139, DOI 10.1017/S0033291700021644
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Hajian-Tilaki KO, 2007, OBES REV, V8, P3, DOI 10.1111/j.1467-789X.2006.00235.x
   HEATHERTON TF, 1991, J PERS SOC PSYCHOL, V60, P138, DOI 10.1037/0022-3514.60.1.138
   Holmes ME, 2010, OBES REV, V11, P492, DOI 10.1111/j.1467-789X.2009.00680.x
   Ignatyev Y, 2013, COMMUNITY MENTAL HLT
   Janghorbani M, 2007, OBESITY, V15, P2797, DOI 10.1038/oby.2007.332
   Kalra SP, 2004, NEUROPEPTIDES, V38, P201, DOI 10.1016/j.npep.2004.06.003
   Kawakami N, 2006, J EPIDEMIOL, V16, P79, DOI 10.2188/jea.16.79
   Kelishadi R, 2008, PUBLIC HEALTH NUTR, V11, P246, DOI 10.1017/S1368980007000262
   Kouvonen A, 2005, PREV MED, V41, P532, DOI 10.1016/j.ypmed.2005.01.004
   Lallukka T, 2008, SOC SCI MED, V66, P1681, DOI 10.1016/j.socscimed.2007.12.027
   Lobstein T., 2004, OBES REV, V5, P4, DOI [10.1111/j.1467-789X.2004.00133.x, DOI 10.1111/J.1467-789X.2004.00133.X]
   Martens EAP, 2012, PHYSIOL BEHAV, V106, P272, DOI 10.1016/j.physbeh.2012.02.016
   Moljord IEO, 2011, PERCEPT MOTOR SKILL, V113, P631, DOI 10.2466/02.06.10.13.PMS.113.5.631-646
   Montazeri Ali, 2003, Health Qual Life Outcomes, V1, P66, DOI 10.1186/1477-7525-1-66
   Ostry AS, 2006, BMC PUBLIC HEALTH, V6, DOI 10.1186/1471-2458-6-53
   Parker G, 2002, AM J PSYCHIAT, V159, P1470, DOI 10.1176/appi.ajp.159.9.1470
   Rasheed P, 1998, PUBLIC HEALTH, V112, P409, DOI 10.1016/S0033-3506(98)00288-1
   Rosmond R, 2005, PSYCHONEUROENDOCRINO, V30, P1, DOI 10.1016/j.psyneuen.2004.05.007
   Rudenga KJ, 2012, INT J OBES LOND
   Rutters F, 2009, OBESITY, V17, P72, DOI 10.1038/oby.2008.493
   Rutters F, 2010, PATIENT EDUC COUNS, V79, P367, DOI 10.1016/j.pec.2010.03.013
   Sarraf-Zadegan N, 2003, ACTA CARDIOL, V58, P309, DOI 10.2143/AC.58.4.2005288
   Sarrafzadegan N, 2004, 1 ANN EVALUATION ISF
   Serlachius A, 2007, PHYSIOL BEHAV, V92, P548, DOI 10.1016/j.physbeh.2007.04.032
   Shapiro Jennifer R, 2005, Eat Behav, V6, P169, DOI 10.1016/j.eatbeh.2004.08.001
   Stults-Kolehmainen MA, 2014, SPORTS MED, V44, P81, DOI 10.1007/s40279-013-0090-5
   Stunkard AJ, 2003, BIOL PSYCHIAT, V54, P330, DOI 10.1016/S0006-3223(03)00608-5
   Tamashiro KLK, 2006, PHYSIOL BEHAV, V89, P536, DOI 10.1016/j.physbeh.2006.05.026
   Torres SJ, 2007, NUTRITION, V23, P887, DOI 10.1016/j.nut.2007.08.008
   Viner RM, 2006, INT J OBESITY, V30, P1514, DOI 10.1038/sj.ijo.0803352
   Walders-Abramson N, 2013, CHILD OBES, V9, P319, DOI 10.1089/chi.2012.0120
   Wallis DJ, 2009, APPETITE, V52, P355, DOI 10.1016/j.appet.2008.11.007
   Zellner DA, 2006, PHYSIOL BEHAV, V87, P789, DOI 10.1016/j.physbeh.2006.01.014
   Zellner DA, 2007, APPETITE, V49, P696, DOI 10.1016/j.appet.2007.06.013
NR 46
TC 4
Z9 6
U1 0
U2 17
PU ACAD MEDICAL SCIENCES I R IRAN
PI TEHRAN
PA PO BOX 19395-5655, TEHRAN, 00000, IRAN
SN 1029-2977
EI 1735-3947
J9 ARCH IRAN MED
JI Arch. Iran. Med.
PD SEP
PY 2014
VL 17
IS 9
BP 608
EP 612
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AQ2GL
UT WOS:000342603700003
PM 25204476
DA 2025-06-11
ER

PT J
AU Yasui, T
   Okada, A
   Hamamoto, S
   Ando, R
   Taguchi, K
   Tozawa, K
   Kohri, K
AF Yasui, Takahiro
   Okada, Atsushi
   Hamamoto, Shuzo
   Ando, Ryosuke
   Taguchi, Kazumi
   Tozawa, Keiichi
   Kohri, Kenjiro
TI Pathophysiology-based treatment of urolithiasis
SO INTERNATIONAL JOURNAL OF UROLOGY
LA English
DT Review
DE calcium oxalate; kidney calculi; mitochondria; nephrolithiasis;
   oxidative stress; urolithiasis
ID CALCIUM-OXALATE MONOHYDRATE; TUBULAR EPITHELIAL-CELLS; RENAL CRYSTAL
   DEPOSITION; KIDNEY-STONE FORMATION; METABOLIC SYNDROME; OXIDATIVE
   STRESS; VASCULAR CALCIFICATION; EICOSAPENTAENOIC ACID; JAPANESE
   POPULATION; URINARY-EXCRETION
AB Urolithiasis, a complex multifactorial disease, results from interactions between environmental and genetic factors. Epidemiological studies have shown the association of urolithiasis with a number of lifestyle-related diseases, including cardiovascular diseases, hypertension, chronic kidney disease, diabetes and metabolic syndrome. Elucidation of the mechanisms underlying urinary stone formation will enable development of new preventive treatments. The present article reviews the epidemiology, pathophysiology and potential treatment of urolithiasis. Recent literature has shown that oxidative stress and reactive oxygen species could be one such mechanistic pathway. Calcium oxalate crystals adhering to renal tubular cells are incorporated into the cells through the involvement of osteopontin. Stimulation of crystal-cell adhesion impairs acceleration of the mitochondrial permeability transition pore in tubular cells, resulting in mitochondrial collapse, oxidative stress and activation of the apoptotic pathway in the initial steps of renal calcium crystallization. With regard to genetic factors, studies show that single nucleotide polymorphisms in genes encoding calcium-sensing receptor, vitamin D receptor and osteopontin are correlated with urolithiasis. Genome-wide association studies have shown that CLDN14 and NPT2 are associated with urolithiasis in Caucasian and Japanese populations, respectively. Thus, single nucleotide polymorphism analysis would aid in the prediction of urolithiasis risk and recurrence. New diagnostic methods and preventive approaches, along with complete removal of stones, will improve the management of urolithiasis.
C1 [Yasui, Takahiro; Okada, Atsushi; Hamamoto, Shuzo; Ando, Ryosuke; Taguchi, Kazumi; Tozawa, Keiichi; Kohri, Kenjiro] Nagoya City Univ, Grad Sch Med Sci, Dept Nephrourol, Nagoya, Aichi, Japan.
C3 Nagoya City University
RP Yasui, T (corresponding author), Nagoya City Univ, Grad Sch Med Sci, Dept Nephrourol, Mizuho Ku, 1 Kawasumi,Mizuho Cho, Nagoya, Aichi 4678601, Japan.
EM yasui@med.nagoya-cu.ac.jp
RI YASUI, Takahiro/E-6401-2018; Taguchi, Kazumi/AFU-4486-2022
OI Yasui, Takahiro/0000-0003-2197-2477; Taguchi, Kazumi/0000-0002-3092-5114
FU Ministry of Education, Culture, Science and Technology [16790922,
   18791132, 20591887, 23592375, 23249074, 24659716, 24592434, 25462520,
   25670685, 15K10627]; Takeda Science Foundation; Japanese Urological
   Association; Grants-in-Aid for Scientific Research [24659716, 25462520,
   15K10627, 20591887, 23249074, 18791132, 24592434, 16790922, 23592375,
   25670685] Funding Source: KAKEN
FX This work was supported by Grants-in-Aid from the Ministry of Education,
   Culture, Science and Technology (16790922, 18791132, 20591887, 23592375,
   23249074, 24659716, 24592434, 25462520, 25670685, 15K10627); the Takeda
   Science Foundation; and the Japanese Urological Association.
CR Ando R, 2013, J UROLOGY, V189, P1340, DOI 10.1016/j.juro.2012.11.045
   Ando R, 2011, INT J UROL, V18, P131, DOI 10.1111/j.1442-2042.2010.02690.x
   Asselman M, 2003, J AM SOC NEPHROL, V14, P3155, DOI 10.1097/01.ASN.0000099380.18995.F7
   Bigelow MW, 1996, J UROLOGY, V155, P1094, DOI 10.1016/S0022-5347(01)66398-5
   Brookes AJ, 1999, GENE, V234, P177, DOI 10.1016/S0378-1119(99)00219-X
   BUCK AC, 1991, J UROLOGY, V146, P188, DOI 10.1016/S0022-5347(17)37750-9
   Cao LC, 2004, KIDNEY INT, V66, P1890, DOI 10.1111/j.1523-1755.2004.00963.x
   Curhan GC, 1997, J AM SOC NEPHROL, V8, P1568
   Delvecchio FC, 2005, UROL RES, V33, P448, DOI 10.1007/s00240-005-0506-2
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Eisner BH, 2010, J UROLOGY, V183, P2244, DOI 10.1016/j.juro.2010.02.007
   Eisner BH, 2010, J UROLOGY, V183, P576, DOI 10.1016/j.juro.2009.10.011
   Farber CR, 2009, J BONE MINER RES, V24, P1937, DOI [10.1359/jbmr.091101, 10.1359/JBMR.091101]
   Fujii Y, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061343
   Gao B, 2007, KIDNEY INT, V72, P592, DOI 10.1038/sj.ki.5002345
   Gao B, 2005, J UROLOGY, V174, P1472, DOI 10.1097/01.ju.0000173012.28341.c3
   Gao B, 2007, J UROLOGY, V177, P2361, DOI 10.1016/j.juro.2007.01.118
   GILL WB, 1982, J UROLOGY, V127, P152, DOI 10.1016/S0022-5347(17)53650-2
   Goldfarb DS, 2005, KIDNEY INT, V67, P1053, DOI 10.1111/j.1523-1755.2005.00170.x
   Heller HJ, 2002, J UROLOGY, V168, P1923, DOI 10.1016/S0022-5347(05)64264-4
   Hesse A, 2003, EUR UROL, V44, P709, DOI 10.1016/S0302-2838(03)00415-9
   Hirose M, 2012, UROL RES, V40, P121, DOI 10.1007/s00240-011-0400-z
   Hirose M, 2010, INT J UROL, V17, P83, DOI 10.1111/j.1442-2042.2009.02410.x
   Itoh Y, 2005, UROL RES, V33, P261, DOI 10.1007/s00240-005-0465-7
   Itoh Y, 2005, J UROLOGY, V173, P271, DOI 10.1097/01.ju.0000141311.51003.87
   Itoh Yasunori, 2011, Arch Ital Urol Androl, V83, P23
   Jeong IG, 2011, AM J KIDNEY DIS, V58, P383, DOI 10.1053/j.ajkd.2011.03.021
   Jirtle RL, 2007, NAT REV GENET, V8, P253, DOI 10.1038/nrg2045
   Johnson RC, 2006, CIRC RES, V99, P1044, DOI 10.1161/01.RES.0000249379.55535.21
   Kadowaki T, 2005, ENDOCR REV, V26, P439, DOI 10.1210/er.2005-0005
   Kapur K, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1001035
   Khan Saeed R, 2004, Clin Exp Nephrol, V8, P75
   Khan SR, 2013, J UROLOGY, V189, P803, DOI 10.1016/j.juro.2012.05.078
   Khan SR, 2005, UROL RES, V33, P349, DOI 10.1007/s00240-005-0492-4
   Khan SR, 2002, KIDNEY INT, V62, P2062, DOI 10.1046/j.1523-1755.2002.00676.x
   Kohjimoto Y, 1999, KIDNEY INT, V56, P1432, DOI 10.1046/j.1523-1755.1999.00683.x
   Kohjimoto Y, 2013, AM J KIDNEY DIS, V61, P923, DOI 10.1053/j.ajkd.2012.12.028
   KOHRI K, 1993, J BIOL CHEM, V268, P15180
   Kohri K, 2012, UROL RES, V40, P623, DOI 10.1007/s00240-012-0514-y
   LIESKE JC, 1995, AM J PHYSIOL-RENAL, V268, pF604, DOI 10.1152/ajprenal.1995.268.4.F604
   Negri AL, 2008, UROL RES, V36, P303, DOI 10.1007/s00240-008-0161-5
   Madore F, 1998, AM J HYPERTENS, V11, P46, DOI 10.1016/S0895-7061(97)00371-3
   Madore F, 1998, AM J KIDNEY DIS, V32, P802, DOI 10.1016/S0272-6386(98)70136-2
   Matsuda M, 2002, J BIOL CHEM, V277, P37487, DOI 10.1074/jbc.M206083200
   MCKEE MD, 1995, J BONE MINER RES, V10, P1913
   Mossetti G, 2004, NEPHROL DIAL TRANSPL, V19, P2259, DOI 10.1093/ndt/gfh273
   Niimi K, 2014, INT J UROL, V21, P707, DOI 10.1111/iju.12425
   Niimi K, 2012, FREE RADICAL BIO MED, V52, P1207, DOI 10.1016/j.freeradbiomed.2012.01.005
   NORDIN BEC, 1991, J CLIN ENDOCR METAB, V72, P401, DOI 10.1210/jcem-72-2-401
   Okada A, 2008, J BONE MINER RES, V23, P1629, DOI 10.1359/JBMR.080514
   Osako MK, 2010, CIRC RES, V107, P466, DOI 10.1161/CIRCRESAHA.110.216846
   Sarica K, 2008, UROLOGY, V71, P771, DOI 10.1016/j.urology.2007.11.164
   Scatena M, 2007, ARTERIOSCL THROM VAS, V27, P2302, DOI 10.1161/ATVBAHA.107.144824
   Schmiedl A, 2000, UROL RES, V28, P404, DOI 10.1007/s002400000144
   Stamatelou KK, 2003, KIDNEY INT, V63, P1817, DOI 10.1046/j.1523-1755.2003.00917.x
   Strohmaier WL, 2000, EUR UROL, V37, P339, DOI 10.1159/000052367
   Taguchi K, 2015, J UROLOGY, V194, P1787, DOI 10.1016/j.juro.2015.07.083
   Taguchi K, 2012, J UROLOGY, V188, P1002, DOI 10.1016/j.juro.2012.04.103
   Tasca A, 2011, CURR OPIN UROL, V21, P129, DOI 10.1097/MOU.0b013e3283435cbc
   Taylor EN, 2005, JAMA-J AM MED ASSOC, V293, P455, DOI 10.1001/jama.293.4.455
   Taylor EN, 2005, KIDNEY INT, V68, P1230, DOI 10.1111/j.1523-1755.2005.00516.x
   Taylor EN, 2006, AM J KIDNEY DIS, V47, P780, DOI 10.1053/j.ajkd.2006.01.024
   Thamilselvan S, 2000, J UROLOGY, V164, P224, DOI 10.1016/S0022-5347(05)67499-X
   Thorleifsson G, 2009, NAT GENET, V41, P926, DOI 10.1038/ng.404
   Trinchieri A, 2000, EUR UROL, V37, P23, DOI 10.1159/000020094
   Umekawa T, 2005, NEPHROL DIAL TRANSPL, V20, P870, DOI 10.1093/ndt/gfh750
   Umekawa T, 2004, J AM SOC NEPHROL, V15, P635, DOI 10.1097/01.ASN.0000113321.49771.2D
   Urabe Y, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002541
   Verkoelen CF, 1998, AM J PHYSIOL-RENAL, V274, pF958, DOI 10.1152/ajprenal.1998.274.5.F958
   Vezzoli G, 2011, KIDNEY INT, V80, P587, DOI 10.1038/ki.2010.430
   Vezzoli G, 2010, NEPHROL DIAL TRANSPL, V25, P2245, DOI 10.1093/ndt/gfp760
   West B, 2008, AM J KIDNEY DIS, V51, P741, DOI 10.1053/j.ajkd.2007.12.030
   Wiessner JH, 2001, KIDNEY INT, V59, P637, DOI 10.1046/j.1523-1755.2001.059002637.x
   Worcester EM, 2010, NEW ENGL J MED, V363, P954, DOI 10.1056/NEJMcp1001011
   Yasui T, 2007, SCAND J UROL NEPHROL, V41, P419, DOI 10.1080/00365590701318296
   Yasui T, 2008, UROL INT, V81, P135, DOI 10.1159/000144050
   Yasui T, 2008, UROLOGY, V71, P209, DOI 10.1016/j.urology.2007.09.034
   Yasui T, 2013, J HUM GENET, V58, P588, DOI 10.1038/jhg.2013.59
NR 78
TC 73
Z9 81
U1 1
U2 12
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0919-8172
EI 1442-2042
J9 INT J UROL
JI Int. J. Urol.
PD JAN
PY 2017
VL 24
IS 1
BP 32
EP 38
DI 10.1111/iju.13187
PG 7
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA EJ6BY
UT WOS:000393304700005
PM 27539983
OA Bronze
DA 2025-06-11
ER

PT J
AU Diaz-Gerevini, GT
   Repossi, G
   Dain, A
   Tarres, MC
   Das, UN
   Eynard, AR
AF Tomas Diaz-Gerevini, Gustavo
   Repossi, Gaston
   Dain, Alejandro
   Cristina Tarres, Maria
   Das, Undurti Narasimha
   Renato Eynard, Aldo
TI Beneficial action of resveratrol: How and why?
SO NUTRITION
LA English
DT Review
DE Resveratrol; Flavonoids; Type 2 diabetes mellitus; Obesity; Alzheimer's
   disease; Microbiota
ID ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE; MOUSE MODEL;
   INDUCTION; AUTOPHAGY; SIRT1; APOPTOSIS; AUTISM; NANOPARTICLES;
   INHIBITION
AB Flavonoid resveratrol modulates the transcription factor NF-kappa B; inhibits the cytochrome P450 isoenzyme CYP1 A1; suppresses the expression and activity of cyclooxygenase enzymes; and modulates Fas/Fas-ligand-mediated apoptosis, p53, mammalian target of rapamycin, and cyclins and various phosphodiesterases. This increases the cytosolic cAMP that activates Epac1/CaMKK beta/AMPK/SIRT1/PGC-1 alpha a pathway, which in turn facilitates increased oxidation of fatty acids, mitochondria) biogenesis, mitochondrial respiration, and gluconeogenesis. Resveratrol triggers apoptosis of activated T cells and suppresses tumor necrosis factor-alpha, interluekin-17 (IL-17), and other proinflammatory molecules, and thus is of benefit in autoimmune diseases. In addition, resveratrol inhibits expression of hypoxia-inducible factor-1 alpha and vascular endothelial growth factor, explaining its effective action against cancer. Brain-derived neurotrophic factor (BDNF) that is involved in the pathogenesis of obesity, type 2 diabetes mellitus, and metabolic syndrome is also altered in depression, schizophrenia, bipolar disorder, and autism. We noted that BDNF protects against cytotoxic actions of alloxan, streptozotocin, and benzo(a)pyrene. Resveratrol prevents bisphenol A-induced autism, type 2 diabetes mellitus, and metabolic syndrome, suggesting that it may augment BDNF synthesis and action. We also observed that BDNF levels are low in type 2 diabetes mellitus and that BDNF enhances production of antiinflammatory lipid, lipoxin A4, whose levels are low in diabetes mellitus. Thus, resveratrol may augment production of lipoxin A4. Resveratrol alters gut microbiota and influences stem cell proliferation and differentiation. These pleiotropic actions of resveratrol may explain the multitude of its actions and benefits. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Tomas Diaz-Gerevini, Gustavo; Repossi, Gaston; Dain, Alejandro; Renato Eynard, Aldo] Univ Nacl Cordoba, Biol Celular Histol & Embriol, Fac Ciencias Med, INICSA,CONICET, RA-5000 Cordoba, Argentina.
   [Repossi, Gaston] Univ Nacl Rioja, Catedra Histol Embriol & Genet, La Rioja, Argentina.
   [Repossi, Gaston; Cristina Tarres, Maria; Renato Eynard, Aldo] Consejo Nacl Invest Cient & Tecn, Cordoba, Argentina.
   [Cristina Tarres, Maria] Univ Nacl Rosario, Fac Ciencias Med, RA-2000 Rosario, Santa Fe, Argentina.
   [Das, Undurti Narasimha] GVP Hosp, Dept Med, Campus Gayatri Vidya Parishad Coll Engn, Visakhapatnam, Andhra Pradesh, India.
   [Das, Undurti Narasimha] BioSci Res Ctr, Campus Gayatri Vidya Parishad Coll Engn, Visakhapatnam, Andhra Pradesh, India.
   [Das, Undurti Narasimha] UND Life Sci, Fed Way, Washington, DC USA.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   National University of Cordoba; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); National University of Rosario
RP Eynard, AR (corresponding author), Univ Nacl Cordoba, Biol Celular Histol & Embriol, Fac Ciencias Med, INICSA,CONICET, RA-5000 Cordoba, Argentina.; Eynard, AR (corresponding author), Consejo Nacl Invest Cient & Tecn, Cordoba, Argentina.
EM aeynard@gmail.com
RI Das, Undurti/A-7918-2009
CR Alcain FJ, 2009, EXPERT OPIN THER PAT, V19, P403, DOI 10.1517/13543770902762893
   Bambini V, 2014, NEUROSCI LETT, V583, P176, DOI 10.1016/j.neulet.2014.09.039
   Bettelli E, 2008, NATURE, V453, P1051, DOI 10.1038/nature07036
   Brunet A, 2004, SCIENCE, V303, P2011, DOI 10.1126/science.1094637
   Cai H, 2015, SCI TRANSL MED, V7, DOI 10.1126/scitranslmed.aaa7619
   Cao Y, 2005, J ASIAN NAT PROD RES, V7, P205, DOI 10.1080/10286020410001690190
   Chen YB, 2015, CELL STRESS CHAPERON, V20, P643, DOI 10.1007/s12192-015-0588-x
   Chun YJ, 1999, BIOCHEM BIOPH RES CO, V262, P20, DOI 10.1006/bbrc.1999.1152
   Côté CD, 2015, NAT MED, V21, P498, DOI 10.1038/nm.3821
   Das UN, 2013, NUTRITION, V29, P1175, DOI 10.1016/j.nut.2013.01.012
   Das UN, 2013, PROSTAG LEUKOTR ESS, V88, P201, DOI 10.1016/j.plefa.2012.11.009
   Das UN, 2010, NUTRITION, V26, P459, DOI 10.1016/j.nut.2009.09.020
   Denu JM, 2012, CELL METAB, V15, P566, DOI 10.1016/j.cmet.2012.04.016
   Dominguez-Villar M, 2011, SCIENCE, V332, P47, DOI 10.1126/science.1205311
   Duca FA, 2015, NAT MED, V21, P506, DOI 10.1038/nm.3787
   Fujino S, 2003, GUT, V52, P65, DOI 10.1136/gut.52.1.65
   Gao XZ, 2012, ANN RHEUM DIS, V71, P129, DOI 10.1136/ard.2011.149831
   Hu FB, 2011, DIABETES CARE, V34, P1249, DOI 10.2337/dc11-0442
   Hung LM, 2000, CARDIOVASC RES, V47, P549, DOI 10.1016/S0008-6363(00)00102-4
   Imler TJ, 2009, INT IMMUNOPHARMACOL, V9, P134, DOI 10.1016/j.intimp.2008.10.015
   Juárez-Rojas JG, 2014, REV ENDOCR METAB DIS, V15, P307, DOI 10.1007/s11154-014-9295-7
   Kaviarasan K, 2015, METABOLISM, V64, P958, DOI 10.1016/j.metabol.2015.04.005
   Khan MA, 2013, MOL CELLS, V35, P219, DOI 10.1007/s10059-013-2259-z
   Kjaer TN, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0126599
   Knight JA, 2011, ANN CLIN LAB SCI, V41, P107
   Komiyama Y, 2006, J IMMUNOL, V177, P566, DOI 10.4049/jimmunol.177.1.566
   Kops GJPL, 2002, NATURE, V419, P316, DOI 10.1038/nature01036
   Kumar R, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0089742
   Kundakovic M, 2015, P NATL ACAD SCI USA, V112, P6807, DOI 10.1073/pnas.1408355111
   Lagouge M, 2006, CELL, V127, P1109, DOI 10.1016/j.cell.2006.11.013
   Lam DW, 2012, CURR OPIN ENDOCRINOL, V19, P93, DOI 10.1097/MED.0b013e328350583a
   Lanzilli G, 2012, INFLAMMATION, V35, P240, DOI 10.1007/s10753-011-9310-z
   Lee Ye-Ming, 2012, Evid Based Complement Alternat Med, V2012, P852362, DOI 10.1155/2012/852362
   Leiro J, 2005, INT IMMUNOPHARMACOL, V5, P393, DOI 10.1016/j.intimp.2004.10.006
   Lindner GD, 2015, NANOMEDICINE-UK, V10, P1127, DOI [10.2217/NNM.14.165, 10.2217/nnm.14.165]
   Nakae S, 2003, J IMMUNOL, V171, P6173, DOI 10.4049/jimmunol.171.11.6173
   Park SJ, 2012, CELL, V148, P421, DOI 10.1016/j.cell.2012.01.017
   Pasinetti GM, 2015, BBA-MOL BASIS DIS, V1852, P1202, DOI 10.1016/j.bbadis.2014.10.006
   Penalva R, 2015, J AGR FOOD CHEM, V63, P5603, DOI 10.1021/jf505694e
   Pezzolla D, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0119904
   Polavarapu S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0114766
   Qiao Y, 2014, FOOD FUNCT, V5, P1241, DOI 10.1039/c3fo60630a
   Robb EL, 2008, BIOCHEM BIOPH RES CO, V367, P406, DOI 10.1016/j.bbrc.2007.12.138
   Sajish M, 2015, NATURE, V519, P370, DOI 10.1038/nature14028
   Savastano S, 2015, J TRANSL MED, V13, DOI 10.1186/s12967-015-0532-y
   Seong H, 2015, MOL MED REP, V12, P1479, DOI 10.3892/mmr.2015.3518
   Singh NP, 2007, MOL PHARMACOL, V72, P1508, DOI 10.1124/mol.107.038984
   Stefani M, 2007, ANN NY ACAD SCI, V1114, P407, DOI 10.1196/annals.1396.001
   Stein TP, 2015, AUTISM RES, V8, P272, DOI 10.1002/aur.1444
   Stienstra R, 2014, DIABETOLOGIA, V57, P1505, DOI 10.1007/s00125-014-3255-3
   Tan SH, 2012, J BIOL CHEM, V287, P14364, DOI 10.1074/jbc.M111.294157
   Tennen RI, 2012, CELL, V148, P387, DOI 10.1016/j.cell.2012.01.032
   Trapp V, 2010, ANGIOGENESIS, V13, P305, DOI 10.1007/s10456-010-9187-8
   Vetrivel U, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-109
   Yao J, 2015, WORLD J GASTROENTERO, V21, P6572, DOI 10.3748/wjg.v21.i21.6572
   Yin JJ, 2015, INT J MOL MED, V35, P932, DOI 10.3892/ijmm.2015.2085
   Yorimitsu T, 2006, J BIOL CHEM, V281, P30299, DOI 10.1074/jbc.M607007200
   Zhang M, 2014, PLOS ONE, V9, DOI [10.1371/journal.pone.0105994, 10.1371/journal.pone.0109589]
NR 58
TC 217
Z9 237
U1 4
U2 332
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD FEB
PY 2016
VL 32
IS 2
BP 174
EP 178
DI 10.1016/j.nut.2015.08.017
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DC8KM
UT WOS:000369468400003
PM 26706021
OA Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Rew, KT
   Heidelbaugh, JJ
AF Rew, Karl T.
   Heidelbaugh, Joel J.
TI Erectile Dysfunction
SO AMERICAN FAMILY PHYSICIAN
LA English
DT Article
ID CORONARY-ARTERY-DISEASE; OF-THE-LITERATURE; CARDIOVASCULAR-DISEASE;
   SEXUAL DYSFUNCTION; METABOLIC SYNDROME; RISK-FACTORS; OBESE MEN;
   HYPOGONADOTROPIC HYPOGONADISM; ENDOTHELIAL DYSFUNCTION;
   PSYCHOTROPIC-DRUGS
AB Erectile dysfunction (ED) is the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. It is common, affecting at least 12 million U.S. men. The five-question International Index of Erectile Function allows rapid clinical assessment of ED. The condition can be caused by vascular, neurologic, psychological, and hormonal factors. Common conditions related to ED include diabetes mellitus, hypertension, hyperlipidemia, obesity, testosterone deficiency, and prostate cancer treatment. Performance anxiety and relationship issues are common psychological causes. Medications and substance use can cause or exacerbate ED; antidepressants and tobacco use are the most common. ED is associated with an increased risk of cardiovascular disease, particularly in men with metabolic syndrome. Tobacco cessation, regular exercise, weight loss, and improved control of diabetes, hypertension, and hyperlipidemia are recommended initial lifestyle interventions. Oral phosphodiesterase-5 inhibitors are the first line treatments for ED. Second-line treatments include alprostadil and vacuum devices. Surgically implanted penile prostheses are an option when other treatments have been ineffective. Counseling is recommended for men with psychogenic ED. (Copyright (C) 2016 American Academy of Family Physicians.)
C1 [Rew, Karl T.; Heidelbaugh, Joel J.] Univ Michigan, Sch Med, Dept Family Med, 24 Frank Lloyd Wright Dr, Ann Arbor, MI 48105 USA.
   [Rew, Karl T.; Heidelbaugh, Joel J.] Univ Michigan, Sch Med, Dept Urol, 24 Frank Lloyd Wright Dr, Ann Arbor, MI 48105 USA.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan
RP Rew, KT (corresponding author), Univ Michigan, Sch Med, 24 Frank Lloyd Wright Dr, Ann Arbor, MI 48105 USA.
EM karlr@med.umich.edu
CR AI-Hunayan A, 2007, BJU INT, V99, P130
   Araujo AB, 2009, J SEX MED, V6, P2445, DOI 10.1111/j.1743-6109.2009.01354.x
   Aslan Y, 2009, UROLOGY, V74, P561, DOI 10.1016/j.urology.2009.02.073
   Bacon CG, 2002, DIABETES CARE, V25, P1458, DOI 10.2337/diacare.25.8.1458
   Bal K, 2007, UROLOGY, V69, P356, DOI 10.1016/j.urology.2006.09.057
   Belew Daniel, 2015, Sex Med Rev, V3, P11, DOI 10.1002/smrj.35
   Besiroglu H, 2015, J SEX MED, V12, P1309, DOI 10.1111/jsm.12885
   Billups KL, 2005, J SEX MED, V2, P40, DOI 10.1111/j.1743-6109.2005.20104_1.x
   Blumentals W A, 2003, Aging Male, V6, P217, DOI 10.1080/13685530312331309752
   Brant WO, 2007, ENDOCRIN METAB CLIN, V36, P465, DOI 10.1016/j.ecl.2007.02.001
   Cao SY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0060443
   Chew KK, 2010, J SEX MED, V7, P192, DOI 10.1111/j.1743-6109.2009.01576.x
   Cohen PG, 1998, MED HYPOTHESES, V50, P331, DOI 10.1016/S0306-9877(98)90006-8
   Corona G, 2009, INT J ANDROL, V32, P720, DOI 10.1111/j.1365-2605.2009.00952.x
   Corona G, 2013, EUR J ENDOCRINOL, V168, P829, DOI 10.1530/EJE-12-0955
   Costa P, 2012, DRUGS, V72, P2243, DOI 10.2165/11641380-000000000-00000
   Demir T, 2006, INT J UROL, V13, P385, DOI 10.1111/j.1442-2042.2006.01310.x
   Derby CA, 2000, INT J IMPOT RES, V12, P197, DOI 10.1038/sj.ijir.3900542
   Dong JY, 2011, J AM COLL CARDIOL, V58, P1378, DOI 10.1016/j.jacc.2011.06.024
   DROLLER MJ, 1993, JAMA-J AM MED ASSOC, V270, P83
   Eardley Ian, 2013, Sex Med Rev, V1, P3, DOI 10.1002/smrj.2
   El-Sakka AI, 2004, J UROLOGY, V172, P251, DOI 10.1097/01.ju.0000128572.31000.f0
   Gareri P, 2014, INT J ENDOCRINOL, V2014, DOI 10.1155/2014/878670
   Gazzaruso C, 2004, CIRCULATION, V110, P22, DOI 10.1161/01.CIR.0000133278.81226.C9
   Giugliano F, 2004, J ENDOCRINOL INVEST, V27, P665, DOI 10.1007/BF03347500
   Gupta BP, 2011, ARCH INTERN MED, V171, P1797, DOI 10.1001/archinternmed.2011.440
   Gurtner K, 2015, AM J MENS HLTH
   Hatzimouratidis K, 2010, EUR UROL, V57, P804, DOI 10.1016/j.eururo.2010.02.020
   Hawksworth DJ, 2015, CLIN PHARMACOL THER, V98, P602, DOI 10.1002/cpt.261
   Heidelbaugh JJ, 2010, AM FAM PHYSICIAN, V81, P305
   Hodges LD, 2007, INT J CLIN PRACT, V61, P2019, DOI 10.1111/j.1742-1241.2007.01629.x
   Howden L M., 2011, 2010 Census Summary File 1 SF1, P16
   Inman BA, 2009, MAYO CLIN PROC, V84, P108, DOI 10.4065/84.2.108
   Kostis JB, 2005, AM J CARDIOL, V96, P313, DOI 10.1016/j.amjcard.2005.03.065
   Kostis JB, 2014, J SEX MED, V11, P1626, DOI 10.1111/jsm.12521
   La Torre A, 2013, PHARMACOPSYCHIATRY, V46, P201, DOI 10.1055/s-0033-1347177
   La Torre A, 2013, PHARMACOPSYCHIATRY, V46, P191, DOI 10.1055/s-0033-1345205
   Lombardi G, 2012, J SEX MED, V9, P970, DOI 10.1111/j.1743-6109.2011.02615.x
   Makhlouf A, 2007, UROL CLIN N AM, V34, P565, DOI 10.1016/j.ucl.2007.08.009
   Marma AK, 2010, CIRC-CARDIOVASC QUAL, V3, P8, DOI 10.1161/CIRCOUTCOMES.109.869727
   Mayans Laura, 2015, FP Essent, V435, P11
   McVary KT, 2007, NEW ENGL J MED, V357, P2472, DOI 10.1056/NEJMcp067261
   Miller TA, 2000, AM FAM PHYSICIAN, V61, P95
   Montague DK, MANAGEMENT ERECTILE
   Montorsi F, 2003, EUR UROL, V44, P360, DOI 10.1016/S0302-2838(03)00305-1
   Montorsi P, 2006, EUR HEART J, V27, P2632, DOI 10.1093/eurheartj/ehl142
   Naya M, 2007, HYPERTENS RES, V30, P541, DOI 10.1291/hypres.30.541
   Nehra A, 2012, MAYO CLIN PROC, V87, P766, DOI 10.1016/j.mayocp.2012.06.015
   OLEARY MP, 1995, UROLOGY, V46, P697, DOI 10.1016/S0090-4295(99)80304-5
   Paduch DA, 2014, UROLOGY, V83, P980, DOI 10.1016/j.urology.2013.12.024
   Pahlajani G, 2012, J SEX MED, V9, P1182, DOI 10.1111/j.1743-6109.2010.01881.x
   Papagiannopoulos D, 2015, ASIAN J ANDROL, V17, P11, DOI 10.4103/1008-682X.139253
   Ponholzer A, 2005, EUR UROL, V47, P80, DOI 10.1016/j.eururo.2004.08.017
   Porst H, 1998, INT J IMPOT RES, V10, P225, DOI 10.1038/sj.ijir.3900365
   Rosen RC, 2001, UROL CLIN N AM, V28, P269, DOI 10.1016/S0094-0143(05)70137-3
   Rosen RC, 1999, INT J IMPOT RES, V11, P319, DOI 10.1038/sj.ijir.3900472
   Saigal CS, 2006, ARCH INTERN MED, V166, P207, DOI 10.1001/archinte.166.2.207
   Shabsigh R, 2004, J UROLOGY, V172, P658, DOI 10.1097/01.ju.0000132389.97804.d7
   Shamloul R, 2011, J SEX MED, V8, P971, DOI 10.1111/j.1743-6109.2010.02198.x
   Skeldon SC, 2015, ANN FAM MED, V13, P331, DOI 10.1370/afm.1816
   Solomon H, 2003, AM J CARDIOL, V91, P230, DOI 10.1016/S0002-9149(02)03113-2
   Thompson IM, 2005, JAMA-J AM MED ASSOC, V294, P2996, DOI 10.1001/jama.294.23.2996
   Tomada N, 2011, J SEX MED, V8, P831, DOI 10.1111/j.1743-6109.2010.02122.x
   Üekert S, 2013, EXPERT REV CLIN PHAR, V6, P323, DOI [10.1586/ECP.13.16, 10.1586/ecp.13.16]
   VERMEULEN A, 1993, J CLIN ENDOCR METAB, V76, P1140, DOI 10.1210/jc.76.5.1140
   Verze P, 2015, EUR UROL FOCUS, V1, P39, DOI 10.1016/j.euf.2015.01.003
   Viera AJ, 1999, AM FAM PHYSICIAN, V60, P1159
   Vlachopoulos C, 2005, EUR UROL, V48, P996, DOI 10.1016/j.eururo.2005.08.002
   Vlachopoulos C, 2006, EUR HEART J, V27, P2640, DOI 10.1093/eurheartj/ehl341
   Yuan JQ, 2013, EUR UROL, V63, P902, DOI 10.1016/j.eururo.2013.01.012
   Zumoff B, 2003, METABOLISM, V52, P1126, DOI 10.1016/S0026-0495(03)00186-0
NR 71
TC 84
Z9 91
U1 0
U2 15
PU AMER ACAD FAMILY PHYSICIANS
PI KANSAS CITY
PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA
SN 0002-838X
EI 1532-0650
J9 AM FAM PHYSICIAN
JI Am. Fam. Physician
PD NOV 15
PY 2016
VL 94
IS 10
BP 820
EP 827
PG 8
WC Primary Health Care; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ED2EA
UT WOS:000388655200004
PM 27929275
DA 2025-06-11
ER

PT J
AU Solomon, MB
   Jankord, R
   Flak, JN
   Herman, JP
AF Solomon, Matia B.
   Jankord, Ryan
   Flak, Jonathan N.
   Herman, James P.
TI Chronic stress, energy balance and adiposity in female rats
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Obesity; Leptin; Insulin; Corticosterone; Metabolic syndrome; Diabetes
ID HIGH-FAT-DIET; SYRIAN-HAMSTERS; SOCIAL DEFEAT; BODY-WEIGHT; FOOD-INTAKE;
   ACCESS; MASS
AB Stress preferentially increases the consumption of high fat foods in women, suggesting the interaction of these two factors may disproportionately predispose women toward excess weight gain. In the present study, female rats were exposed to a chronic high fat or chow diet and were exposed to 4 weeks of chronic variable stress (CVS) or served as home cage controls. Control females exposed to a high fat diet displayed many symptoms of the metabolic syndrome including increased body weight gain, total and visceral adiposity and insulin and leptin concentrations relative to all groups. However, CVS-high fat, CVS chow and control chow groups had similar body weight gain and caloric efficiency. This finding suggests that CVS increases energy expenditure much more in females exposed to a high fat diet relative to those fed a standard chow diet. The CVS-high fat group had increased adiposity and increased circulating leptin and insulin concentrations, despite the fact that their body weight did not differ from the controls. These results underscore the importance of assessing the degree of adiposity, rather than body weight alone, as an index of overall metabolic health. Overall, the data indicate that in female rats, chronic stress prevents high fat diet related increases in body weight, but does not prevent high fat diet induced increases in adiposity when compared to chow-fed females. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Solomon, Matia B.; Jankord, Ryan; Flak, Jonathan N.; Herman, James P.] Univ Cincinnati, Coll Med, Dept Psychiat, Cincinnati, OH 45267 USA.
   [Flak, Jonathan N.; Herman, James P.] Univ Cincinnati, Coll Med, Neurosci Program, Cincinnati, OH 45267 USA.
C3 University System of Ohio; University of Cincinnati; University System
   of Ohio; University of Cincinnati
RP Solomon, MB (corresponding author), Univ Cincinnati, Metab Dis Inst, 2170 E Galbraith Rd,Bldg E,Room 216,ML 0506, Cincinnati, OH 45237 USA.
EM matia.solomon@uc.edu
RI Solomon, Matia/KQV-0178-2024; Herman, James/D-4960-2015
OI Herman, James/0000-0003-3571-2406
FU NIH [MH 069725]
FX The authors would like to thank Nathan Evanson, Ph.D., Rong Zhang,
   Ph.D., Yvonne Ulrich-Lai, Ph.D., Anne Christiansen, Kenneth Jones and
   Benjamin Packard for help with tissue collection and help with
   radioimmunoassay. We also thank Michelle Foster, Ph.D. and Stephen Woods
   Ph.D. for thoughtful discussions concerning the manuscript. Finally, we
   would like to thank Diego Perez-tilve for help with the insulin and
   leptin analyses. This work was supported in part by NIH MH 069725 to JPH
   and an ARRA supplement to MBS.
CR Choi DC, 2008, PSYCHONEUROENDOCRINO, V33, P659, DOI 10.1016/j.psyneuen.2008.02.006
   Dallman MF, 2005, BRAIN BEHAV IMMUN, V19, P275, DOI 10.1016/j.bbi.2004.11.004
   Epel E, 2001, PSYCHONEUROENDOCRINO, V26, P37, DOI 10.1016/S0306-4530(00)00035-4
   Foster MT, 2006, AM J PHYSIOL-REG I, V290, pR1284, DOI 10.1152/ajpregu.00437.2005
   Harris RBS, 2006, HORM BEHAV, V49, P615, DOI 10.1016/j.yhbeh.2005.12.001
   Hoffler U, 2009, ENDOCRINE, V36, P311, DOI 10.1007/s12020-009-9224-9
   Kyrou I, 2009, CURR OPIN PHARMACOL, V9, P787, DOI 10.1016/j.coph.2009.08.007
   Lu ZY, 2009, GYNECOL ENDOCRINOL, V25, P464, DOI 10.1080/09513590902770107
   Pecoraro N, 2004, ENDOCRINOLOGY, V145, P3754, DOI 10.1210/en.2004-0305
   Priego T, 2008, OBESITY, V16, P819, DOI 10.1038/oby.2007.117
   Pulliam JVK, 2010, J PSYCHIATR RES, V44, P106, DOI 10.1016/j.jpsychires.2009.05.005
   SHIVELY CA, 1988, ACTA MED SCAND, V723, P71
   Solomon MB, 2010, J NEUROENDOCRINOL, V22, P13, DOI 10.1111/j.1365-2826.2009.01933.x
   Solomon MB, 2007, AM J PHYSIOL-REG I, V292, pR283, DOI 10.1152/ajpregu.00330.2006
   Solomon MB, 2009, PHYSIOL BEHAV, V97, P250, DOI 10.1016/j.physbeh.2009.02.033
   Tamashiro KLK, 2007, AM J PHYSIOL-REG I, V293, pR1864, DOI 10.1152/ajpregu.00371.2007
   Tamashiro KLK, 2004, PHYSIOL BEHAV, V80, P683, DOI 10.1016/j.physbeh.2003.12.002
   Teegarden SL, 2008, PHYSIOL BEHAV, V93, P713, DOI 10.1016/j.physbeh.2007.11.030
   Ulrich-Lai YM, 2007, ENDOCRINOLOGY, V148, P1823, DOI 10.1210/en.2006-1241
   WAJCHENBERG BL, 1995, J CLIN ENDOCR METAB, V80, P2791, DOI 10.1210/jc.80.9.2791
   Wang Y, 2003, ENDOCRINE, V22, P85, DOI 10.1385/ENDO:22:2:85
   Wilson ME, 2008, PHYSIOL BEHAV, V94, P586, DOI 10.1016/j.physbeh.2008.03.019
   Woods SC, 2003, J NUTR, V133, P1081, DOI 10.1093/jn/133.4.1081
NR 23
TC 29
Z9 33
U1 2
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD JAN 10
PY 2011
VL 102
IS 1
BP 84
EP 90
DI 10.1016/j.physbeh.2010.09.024
PG 7
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA 707LL
UT WOS:000286288000013
PM 20932852
OA Green Accepted
DA 2025-06-11
ER

PT J
AU de Morentin, PBM
   Varela, L
   Ferno, J
   Nogueiras, R
   Diéguez, C
   López, M
AF Martinez de Morentin, Pablo B.
   Varela, Luis
   Ferno, Johan
   Nogueiras, Ruben
   Dieguez, Carlos
   Lopez, Miguel
TI Hypothalamic lipotoxicity and the metabolic syndrome
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
LA English
DT Review
DE Endoplasmic reticulum (ER) stress; Fatty acids; Hypothalamus; Lipid
   metabolism; Lipid sensing; Lipotoxicity
ID ENDOPLASMIC-RETICULUM STRESS; ACTIVATED PROTEIN-KINASE; ACID SYNTHASE
   INHIBITOR; FREE FATTY-ACIDS; BETA-CELL DYSFUNCTION; FOOD-INTAKE;
   MALONYL-COA; ADIPOSE-TISSUE; ER STRESS; MAMMALIAN TARGET
AB Ectopic accumulation of lipids in peripheral tissues, such as pancreatic 0 cells, liver, heart and skeletal muscle, leads to lipotoxicity, a process that contributes substantially to the pathophysiology of insulin resistance, type 2 diabetes, steatotic liver disease and heart failure. Current evidence has demonstrated that hypothalamic sensing of circulating lipids and modulation of hypothalamic endogenous fatty acid and lipid metabolism are two bona fide mechanisms modulating energy homeostasis at the whole body level. Key enzymes, such as AMP-activated protein kinase (AMPK) and fatty acid synthase (FAS), as well as intermediate metabolites, such as malonyl-CoA and long-chain fatty acids-CoA (LCFAs-CoA), play a major role in this neuronal network, integrating peripheral signals with classical neuropeptide-based mechanisms. However, one key question to be addressed is whether impairment of lipid metabolism and accumulation of specific lipid species in the hypothalamus, leading to lipotoxicity, have deleterious effects on hypothalamic neurons. In this review, we summarize what is known about hypothalamic lipid metabolism with focus on the events associated to lipotoxicity, such as endoplasmic reticulum (ER) stress in the hypothalamus. A better understanding of these molecular mechanisms will help to identify new drug targets for the treatment of obesity and metabolic syndrome. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Martinez de Morentin, Pablo B.; Varela, Luis; Ferno, Johan; Nogueiras, Ruben; Dieguez, Carlos; Lopez, Miguel] Univ Santiago de Compostela, Inst Invest Sanitaria, Dept Physiol, Sch Med, Santiago De Compostela 15782, A Coruna, Spain.
C3 Universidade de Santiago de Compostela
RP López, M (corresponding author), Univ Santiago de Compostela, Inst Invest Sanitaria, Dept Physiol, Sch Med, S Francisco S-N, Santiago De Compostela 15782, A Coruna, Spain.
EM m.lopez@usc.es
RI Nogueiras, Ruben/AAS-9427-2021; Varela, Luis/ABG-7581-2020; Fernø,
   Johan/D-5024-2011; Lopez, Miguel/ABF-4844-2021; Blanco Martinez de
   Morentin, Pablo/K-5403-2014
OI Nogueiras, Ruben/0000-0002-9976-9930; Lopez, Miguel/0000-0002-7823-1648;
   Blanco Martinez de Morentin, Pablo/0000-0002-0684-3215; Varela,
   Luis/0000-0001-7794-7241; dieguez, carlos/0000-0002-0919-4337
FU Xunta de Galicia [PGIDIT06PXIB208063PR, GRC2006/66]; Fondo
   Investigationes Sanitarias [PI061700]; Ministerio de Educacion y Ciencia
   [BFU2005, RyC-2007-00211]; European Union [Health-F2-2008-223713]
FX This work has been supported by grants from Xunta de Galicia (C.D.:
   PGIDIT06PXIB208063PR and ML: GRC2006/66), Fondo Investigationes
   Sanitarias (M.L.: PI061700), Ministerio de Educacion y Ciencia (C.D.:
   BFU2005; M.L: RyC-2007-00211), European Union (R.N., C.D. and M.L.:
   Health-F2-2008-223713: "Reprobesity"). CIBER de Fisiopatologia de la
   Obesidad y Nutricion is an initiative of ISCIII.
CR Ahima RS, 2000, TRENDS ENDOCRIN MET, V11, P327, DOI 10.1016/S1043-2760(00)00301-5
   Almaguel FG, 2009, J NEUROSCI RES, V87, P1207, DOI 10.1002/jnr.21918
   Alwine JC, 2008, CURR TOP MICROBIOL, V325, P263
   Anderson KA, 2008, CELL METAB, V7, P377, DOI 10.1016/j.cmet.2008.02.011
   Andersson U, 2004, J BIOL CHEM, V279, P12005, DOI 10.1074/jbc.C300557200
   Andrews ZB, 2008, NATURE, V454, P846, DOI 10.1038/nature07181
   Ariyama Y, 2007, OBESITY, V15, P1647, DOI 10.1038/oby.2007.197
   Basseri S, 2008, DEV CELL, V15, P795, DOI 10.1016/j.devcel.2008.11.013
   Benani A, 2007, DIABETES, V56, P152, DOI 10.2337/db06-0440
   Boden G, 2008, DIABETES, V57, P2438, DOI 10.2337/db08-0604
   Calle EE, 2004, NAT REV CANCER, V4, P579, DOI 10.1038/nrc1408
   Campfield LA, 1996, HORM METAB RES, V28, P619, DOI 10.1055/s-2007-979867
   Cha SH, 2008, P NATL ACAD SCI USA, V105, P16871, DOI 10.1073/pnas.0809255105
   Cha SH, 2009, BIOCHEM BIOPH RES CO, V386, P212, DOI 10.1016/j.bbrc.2009.06.017
   Cha SH, 2006, P NATL ACAD SCI USA, V103, P15410, DOI 10.1073/pnas.0607334103
   Cha SH, 2005, P NATL ACAD SCI USA, V102, P14557, DOI 10.1073/pnas.0507300102
   Cha SH, 2004, BIOCHEM BIOPH RES CO, V317, P301, DOI 10.1016/j.bbrc.2004.03.026
   Chakravarthy MV, 2007, J CLIN INVEST, V117, P2539, DOI 10.1172/JCI31183
   Claret M, 2007, J CLIN INVEST, V117, P2325, DOI 10.1172/JCI31516
   Cnop M, 2005, DIABETES, V54, pS97, DOI 10.2337/diabetes.54.suppl_2.S97
   Cnop M, 2001, DIABETES, V50, P1771, DOI 10.2337/diabetes.50.8.1771
   Cnop M, 2008, BIOCHEM SOC T, V36, P348, DOI 10.1042/BST0360348
   Cnop M, 2007, J BIOL CHEM, V282, P3989, DOI 10.1074/jbc.M607627200
   Coll AP, 2007, CELL, V129, P251, DOI 10.1016/j.cell.2007.04.001
   Coppari R, 2009, NAT CLIN PRACT ENDOC, V5, P160, DOI 10.1038/ncpendmet1070
   Cota D, 2006, SCIENCE, V312, P927, DOI 10.1126/science.1124147
   Cota D, 2008, J NEUROSCI, V28, P7202, DOI 10.1523/JNEUROSCI.1389-08.2008
   Cota D, 2007, GASTROENTEROLOGY, V132, P2158, DOI 10.1053/j.gastro.2007.03.049
   Cunha DA, 2008, J CELL SCI, V121, P2308, DOI 10.1242/jcs.026062
   Di Nardo A, 2009, J NEUROSCI, V29, P5926, DOI 10.1523/JNEUROSCI.0778-09.2009
   Eizirik DL, 2008, ENDOCR REV, V29, P42, DOI 10.1210/er.2007-0015
   El-Assaad W, 2003, ENDOCRINOLOGY, V144, P4154, DOI 10.1210/en.2003-0410
   Elouil H, 2007, DIABETOLOGIA, V50, P1442, DOI 10.1007/s00125-007-0674-4
   Endo H, 2007, CANCER RES, V67, P8095, DOI 10.1158/0008-5472.CAN-06-3389
   Farooqi IS, 2005, ANNU REV MED, V56, P443, DOI 10.1146/annurev.med.56.062904.144924
   Farrell GC, 2006, HEPATOLOGY, V43, pS99, DOI 10.1002/hep.20973
   Flier JS, 2004, CELL, V116, P337, DOI 10.1016/S0092-8674(03)01081-X
   Frühbeck G, 2008, OBES METAB-MILAN, V4, P91
   Gao Q, 2007, ANNU REV NEUROSCI, V30, P367, DOI 10.1146/annurev.neuro.30.051606.094324
   Gao S, 2003, P NATL ACAD SCI USA, V100, P5628, DOI 10.1073/pnas.1031698100
   Gao S, 2007, P NATL ACAD SCI USA, V104, P17358, DOI 10.1073/pnas.0708385104
   Haffner SM, 2006, OBESITY, V14, p121S, DOI 10.1038/oby.2006.291
   Hawley SA, 2005, CELL METAB, V2, P9, DOI 10.1016/j.cmet.2005.05.009
   Hayashi T, 2005, J CEREBR BLOOD F MET, V25, P41, DOI 10.1038/sj.jcbfm.9600005
   He W, 2006, NAT NEUROSCI, V9, P227, DOI 10.1038/nn1626
   Hosoi T, 2008, MOL PHARMACOL, V74, P1610, DOI 10.1124/mol.108.050070
   Hotamisligil GS, 2008, INT J OBESITY, V32, pS52, DOI 10.1038/ijo.2008.238
   Hu ZY, 2005, J BIOL CHEM, V280, P39681, DOI 10.1074/jbc.C500398200
   Hu ZY, 2003, P NATL ACAD SCI USA, V100, P12624, DOI 10.1073/pnas.1834402100
   Huang CJ, 2007, DIABETES, V56, P2016, DOI 10.2337/db07-0197
   Hurley RL, 2005, J BIOL CHEM, V280, P29060, DOI 10.1074/jbc.M503824200
   Ilieva EV, 2007, BRAIN, V130, P3111, DOI 10.1093/brain/awm190
   Ishii S, 2008, REGUL PEPTIDES, V151, P164, DOI 10.1016/j.regpep.2008.07.007
   Jin HO, 2009, FREE RADICAL BIO MED, V46, P1158, DOI 10.1016/j.freeradbiomed.2009.01.015
   Kahn BB, 2005, CELL METAB, V1, P15, DOI 10.1016/j.cmet.2004.12.003
   Kim EK, 2004, J BIOL CHEM, V279, P19970, DOI 10.1074/jbc.M402165200
   Kim EK, 2002, AM J PHYSIOL-ENDOC M, V283, pE867, DOI 10.1152/ajpendo.00178.2002
   Kim MS, 2004, NAT MED, V10, P727, DOI 10.1038/nm1061
   Klaus S, 2004, CURR DRUG TARGETS, V5, P241, DOI 10.2174/1389450043490523
   Kola B, 2005, J BIOL CHEM, V280, P25196, DOI 10.1074/jbc.C500175200
   Kubota N, 2007, CELL METAB, V6, P55, DOI 10.1016/j.cmet.2007.06.003
   KUHAJDA FP, 1994, P NATL ACAD SCI USA, V91, P6379, DOI 10.1073/pnas.91.14.6379
   Lage R, 2008, TRENDS MOL MED, V14, P539, DOI 10.1016/j.molmed.2008.09.007
   Lam TKT, 2005, NAT NEUROSCI, V8, P579, DOI 10.1038/nn1456
   Lam TKT, 2005, NAT MED, V11, P320, DOI 10.1038/nm1201
   Lam TKT, 2003, AM J PHYSIOL-ENDOC M, V284, pE281, DOI 10.1152/ajpendo.00332.2002
   Lane MD, 2008, INT J OBESITY, V32, pS49, DOI 10.1038/ijo.2008.123
   Laybutt DR, 2007, DIABETOLOGIA, V50, P752, DOI 10.1007/s00125-006-0590-z
   Le Foll C, 2009, AM J PHYSIOL-REG I, V297, pR655, DOI 10.1152/ajpregu.00223.2009
   LEE Y, 1994, P NATL ACAD SCI USA, V91, P10878, DOI 10.1073/pnas.91.23.10878
   Lelliott C, 2004, INT J OBESITY, V28, pS22, DOI 10.1038/sj.ijo.0802854
   Lin JH, 2008, ANNU REV PATHOL-MECH, V3, P399, DOI 10.1146/annurev.pathmechdis.3.121806.151434
   Lipson KL, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001648
   Lipson KL, 2006, CELL METAB, V4, P245, DOI 10.1016/j.cmet.2006.07.007
   Loftus TM, 2000, SCIENCE, V288, P2379, DOI 10.1126/science.288.5475.2379
   López M, 2006, DIABETES, V55, P1327, DOI 10.2337/db05-1356
   López M, 2008, CURR OPIN CLIN NUTR, V11, P483, DOI 10.1097/MCO.0b013e328302f3d8
   López M, 2008, CELL METAB, V8, P176, DOI 10.1016/j.cmet.2008.08.003
   López M, 2008, CELL METAB, V7, P389, DOI 10.1016/j.cmet.2008.03.006
   López M, 2007, P NUTR SOC, V66, P131, DOI 10.1017/S0029665107005368
   López M, 2007, BIOESSAYS, V29, P248, DOI 10.1002/bies.20539
   Maedler K, 2001, DIABETES, V50, P69, DOI 10.2337/diabetes.50.1.69
   Marra F, 2008, TRENDS MOL MED, V14, P72, DOI 10.1016/j.molmed.2007.12.003
   Matus S, 2008, CURR MOL MED, V8, P157, DOI 10.2174/156652408784221324
   MAYER J, 1955, ANN NY ACAD SCI, V63, P15, DOI 10.1111/j.1749-6632.1955.tb36543.x
   McCrimmon RJ, 2004, DIABETES, V53, P1953, DOI 10.2337/diabetes.53.8.1953
   Medina-Gomez G, 2005, NAT MED, V11, P602, DOI 10.1038/nm0605-602
   Medina-Gomez G, 2007, PUBLIC HEALTH NUTR, V10, P1132, DOI 10.1017/S1368980007000614
   MILLER JC, 1987, J NEUROCHEM, V49, P1507, DOI 10.1111/j.1471-4159.1987.tb01021.x
   Minokoshi Y, 2004, NATURE, V428, P569, DOI 10.1038/nature02440
   Morgan K, 2004, J BIOL CHEM, V279, P31139, DOI 10.1074/jbc.M400458200
   Mori H, 2009, CELL METAB, V9, P362, DOI 10.1016/j.cmet.2009.03.005
   Morton GJ, 2006, NATURE, V443, P289, DOI 10.1038/nature05026
   Myers MG, 2009, CELL METAB, V9, P117, DOI 10.1016/j.cmet.2008.12.001
   Namkoong C, 2005, DIABETES, V54, P63, DOI 10.2337/diabetes.54.1.63
   Nogueiras R, 2008, ANN NY ACAD SCI, V1126, P14, DOI 10.1196/annals.1433.054
   Obici S, 2003, NAT MED, V9, P756, DOI 10.1038/nm873
   Obici S, 2002, DIABETES, V51, P271, DOI 10.2337/diabetes.51.2.271
   Oyadomari S, 2004, CELL DEATH DIFFER, V11, P381, DOI 10.1038/sj.cdd.4401373
   Oyadomari S, 2002, J CLIN INVEST, V109, P525, DOI 10.1172/JCI200214550
   Ozcan L, 2009, CELL METAB, V9, P35, DOI 10.1016/j.cmet.2008.12.004
   Ozean U, 2008, MOL CELL, V29, P541, DOI [10.1016/j.moicel.2007.12.023, 10.1016/j.molcel.2007.12.023]
   Pennuto M, 2008, NEURON, V57, P393, DOI 10.1016/j.neuron.2007.12.021
   Plum L, 2006, J CLIN INVEST, V116, P1761, DOI 10.1172/JCI29063
   Pocai A, 2006, J CLIN INVEST, V116, P1081, DOI 10.1172/JCI26640
   Pocai A, 2005, CELL METAB, V1, P53, DOI 10.1016/j.cmet.2004.11.001
   Pocai A, 2005, NATURE, V434, P1026, DOI 10.1038/nature03439
   Porte D, 2001, DIABETES, V50, pS160, DOI 10.2337/diabetes.50.2007.S160
   Proulx K, 2008, DIABETES, V57, P3231, DOI 10.2337/db07-1690
   Qi KM, 2002, CURR OPIN CLIN NUTR, V5, P133, DOI 10.1097/00075197-200203000-00003
   Rapoport SI, 2001, J MOL NEUROSCI, V16, P243, DOI 10.1385/JMN:16:2-3:243
   Rapoport SI, 1996, LIPIDS, V31, pS97, DOI 10.1007/BF02637059
   RON D, 1992, GENE DEV, V6, P439, DOI 10.1101/gad.6.3.439
   Ron D, 2008, CELL, V132, P24, DOI 10.1016/j.cell.2007.12.017
   Ron D, 2007, NAT REV MOL CELL BIO, V8, P519, DOI 10.1038/nrm2199
   Rosen ED, 2006, NATURE, V444, P847, DOI 10.1038/nature05483
   Ruderman NB, 2003, ENDOCRINOLOGY, V144, P5166, DOI 10.1210/en.2003-0849
   Sarafidis PA, 2006, J HYPERTENS, V24, P621, DOI 10.1097/01.hjh.0000217840.26971.b6
   Schapansky J, 2007, EXP NEUROL, V208, P169, DOI 10.1016/j.expneurol.2007.04.009
   Schujman GE, 2003, DEV CELL, V4, P663, DOI 10.1016/S1534-5807(03)00123-0
   Seo S, 2008, ENDOCR J, V55, P867, DOI 10.1507/endocrj.K08E-091
   Sharma NK, 2008, J CLIN ENDOCR METAB, V93, P4532, DOI 10.1210/jc.2008-1001
   Shimazawa M, 2007, MOL VIS, V13, P578
   Shimizu H, 2008, ENDOCRINOLOGY, V149, P4544, DOI 10.1210/en.2008-0229
   Shimokawa T, 2002, P NATL ACAD SCI USA, V99, P66, DOI 10.1073/pnas.012606199
   Silva RM, 2005, J NEUROCHEM, V95, P974, DOI 10.1111/j.1471-4159.2005.03428.x
   Slawik M, 2006, AGEING RES REV, V5, P144, DOI 10.1016/j.arr.2006.03.004
   Song BB, 2008, J CLIN INVEST, V118, P3378, DOI 10.1172/JCI34587
   Steinberg GR, 2006, ENDOCRINOLOGY, V147, P3906, DOI 10.1210/en.2005-1587
   Stoppa GR, 2008, J ENDOCRINOL, V198, P157, DOI 10.1677/JOE-07-0428
   Tang QQ, 2000, P NATL ACAD SCI USA, V97, P12446, DOI 10.1073/pnas.220425597
   Tartaglia LA, 1995, CELL, V83, P1263, DOI 10.1016/0092-8674(95)90151-5
   Terai K, 2005, MOL CELL BIOL, V25, P9554, DOI 10.1128/MCB.25.21.9554-9575.2005
   Trayhurn P, 2006, J NUTR, V136, p1935S, DOI 10.1093/jn/136.7.1935S
   Tu YJ, 2005, ENDOCRINOLOGY, V146, P486, DOI 10.1210/en.2004-0976
   Unger RH, 2005, BIOCHIMIE, V87, P57, DOI 10.1016/j.biochi.2004.11.014
   Unger RH, 2002, ANNU REV MED, V53, P319, DOI 10.1146/annurev.med.53.082901.104057
   Unger RH, 2000, INT J OBESITY, V24, pS28, DOI 10.1038/sj.ijo.0801498
   van den Beucken T, 2006, CANCER BIOL THER, V5, P749, DOI 10.4161/cbt.5.7.2972
   Virtue S, 2008, PLOS BIOL, V6, P1819, DOI 10.1371/journal.pbio.0060237
   Wang R, 2006, J NEUROPHYSIOL, V95, P1491, DOI 10.1152/jn.00697.2005
   Wilding JPH, 2007, DIABETIC MED, V24, P934, DOI 10.1111/j.1464-5491.2007.02186.x
   Wolfgang MJ, 2007, P NATL ACAD SCI USA, V104, P19285, DOI 10.1073/pnas.0709778104
   Wolfgang MJ, 2006, P NATL ACAD SCI USA, V103, P7282, DOI 10.1073/pnas.0602205103
   Won JC, 2009, OBESITY, V17, P1861, DOI 10.1038/oby.2009.194
   Woods A, 2005, CELL METAB, V2, P21, DOI 10.1016/j.cmet.2005.06.005
   Woods SC, 2008, ANNU REV NUTR, V28, P295, DOI 10.1146/annurev.nutr.28.061807.155505
   Yang JC, 2009, HEPATOLOGY, V49, P1962, DOI 10.1002/hep.22889
   Yang L, 2008, CELL, V135, P20, DOI 10.1016/j.cell.2008.09.030
   Yusta B, 2006, CELL METAB, V4, P391, DOI 10.1016/j.cmet.2006.10.001
   Zhang XQ, 2008, CELL, V135, P61, DOI 10.1016/j.cell.2008.07.043
   ZHANG YY, 1994, NATURE, V372, P425, DOI 10.1038/372425a0
   Zhou YT, 2000, P NATL ACAD SCI USA, V97, P1784, DOI 10.1073/pnas.97.4.1784
NR 153
TC 55
Z9 56
U1 1
U2 14
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1388-1981
EI 1879-2618
J9 BBA-MOL CELL BIOL L
JI Biochim. Biophys. Acta Mol. Cell Biol. Lipids
PD MAR
PY 2010
VL 1801
IS 3
SI SI
BP 350
EP 361
DI 10.1016/j.bbalip.2009.09.016
PG 12
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 568YT
UT WOS:000275563300019
PM 19796707
DA 2025-06-11
ER

PT J
AU Porter, ML
   Kimball, AB
AF Porter, Martina L.
   Kimball, Alexa B.
TI Comorbidities of hidradenitis suppurativa
SO SEMINARS IN CUTANEOUS MEDICINE AND SURGERY
LA English
DT Article
ID INFLAMMATORY-BOWEL-DISEASE; PYODERMA-GANGRENOSUM; AUTOINFLAMMATORY
   SYNDROME; ACNE CONGLOBATA; SPONDYLOARTHRITIS; COMPLICATIONS; PREVALENCE;
   THERAPY; SMOKING; COHORT
AB Hidradenitis suppurativa (HS) is an inflammatory skin disorder with many associated comorbidities, including obesity, metabolic syndrome, smoking, depression, arthritis, autoinflammatory syndromes, inflammatory bowel disease, and genetic syndromes. In addition, HS patients can suffer from a variety of diseases related to the chronic inflammatory nature of their HS such as cardiovascular disease and anemia. An understanding of these comorbidities and associations is essential for the management of HS, and routine screening for these entities should be considered in all HS patients. (C) 2017 Frontline Medical Communications
C1 [Porter, Martina L.] Massachusetts Gen Hosp, Dept Dermatol, Clin Unit Res Trials & Outcomes Skin CURTIS, Boston, MA 02114 USA.
   [Kimball, Alexa B.] Harvard Med Sch, Dept Dermatol, Boston, MA 02115 USA.
   [Kimball, Alexa B.] Beth Israel Deaconess Med Ctr, Harvard Med Fac Phys, Boston, MA 02215 USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard University; Harvard Medical School; Harvard
   University; Harvard University Medical Affiliates; Beth Israel Deaconess
   Medical Center; Harvard Medical School
RP Kimball, AB (corresponding author), Harvard Med Sch, Dept Dermatol, Boston, MA 02115 USA.; Kimball, AB (corresponding author), Beth Israel Deaconess Med Ctr, Harvard Med Fac Phys, Boston, MA 02215 USA.
EM harvardskinstudies@gmail.com
RI Kimball, Alexandra/M-6347-2019
OI Kimball, Alexandra/0000-0001-9405-0479; Porter,
   Martina/0000-0002-4738-4385
CR Alikhan A, 2009, J AM ACAD DERMATOL, V60, P539, DOI 10.1016/j.jaad.2008.11.911
   ANDERSON BB, 1982, J NATL MED ASSOC, V74, P999
   Braun-Falco M, 2012, J AM ACAD DERMATOL, V66, P409, DOI 10.1016/j.jaad.2010.12.025
   Bruzzese V, 2012, JCR-J CLIN RHEUMATOL, V18, P413, DOI 10.1097/RHU.0b013e318278b84c
   Canoui-Poitrine F, 2009, J AM ACAD DERMATOL, V61, P51, DOI 10.1016/j.jaad.2009.02.013
   Deckers IE, 2017, J AM ACAD DERMATOL, V76, P49, DOI 10.1016/j.jaad.2016.08.031
   Denny G, 2017, J AM ACAD DERMATOL, V76, P54, DOI 10.1016/j.jaad.2016.07.041
   Egeberg A, 2016, JAMA DERMATOL, V152, P429, DOI 10.1001/jamadermatol.2015.6264
   Fimmel S, 2010, DERM-ENDOCRINOL, V2, P9, DOI 10.4161/derm.2.1.12490
   Gold DA, 2014, J AM ACAD DERMATOL, V70, P699, DOI 10.1016/j.jaad.2013.11.014
   Kamal N, 2016, CLIN GASTROENTEROL H, V14, P71, DOI 10.1016/j.cgh.2015.04.180
   Kohorst JJ, 2015, J AM ACAD DERMATOL, V73, pS27, DOI 10.1016/j.jaad.2015.07.055
   Kromann CB, 2014, BRIT J DERMATOL, V171, P819, DOI 10.1111/bjd.13090
   Leuenberger M, 2016, DERMATOLOGY, V232, P254, DOI 10.1159/000443648
   Marzano AV, 2013, JAMA DERMATOL, V149, P762, DOI 10.1001/jamadermatol.2013.2907
   Matusiak L, 2010, J AM ACAD DERMATOL, V62, P706, DOI 10.1016/j.jaad.2009.09.021
   Richette P, 2014, J RHEUMATOL, V41, P490, DOI 10.3899/jrheum.130977
   ROSNER IA, 1993, J RHEUMATOL, V20, P684
   Saraceno R, 2015, J AM ACAD DERMATOL, V72, pE42, DOI 10.1016/j.jaad.2014.10.002
   Sartorius K, 2009, BRIT J DERMATOL, V161, P831, DOI 10.1111/j.1365-2133.2009.09198.x
   Schneider-Burrus S, 2016, DERMATOLOGY, V232, P606, DOI 10.1159/000448838
   Shavit E, 2015, J EUR ACAD DERMATOL, V29, P371, DOI 10.1111/jdv.12567
   Shlyankevich J, 2014, J AM ACAD DERMATOL, V71, P1144, DOI 10.1016/j.jaad.2014.09.012
   van der Zee HH, 2010, BRIT J DERMATOL, V162, P195, DOI 10.1111/j.1365-2133.2009.09430.x
   Vazquez BG, 2013, J INVEST DERMATOL, V133, P97, DOI 10.1038/jid.2012.255
   Von der Werth JM, 2001, BRIT J DERMATOL, V144, P809, DOI 10.1046/j.1365-2133.2001.04137.x
   Vossen AR, 2016, J DERMATOL
   WILLIAMS ST, 1991, ANN PLAS SURG, V26, P456, DOI 10.1097/00000637-199105000-00008
   WILTZ O, 1990, DIS COLON RECTUM, V33, P731, DOI 10.1007/BF02052316
   Yadav S, 2016, CLIN GASTROENTEROL H, V14, P65, DOI 10.1016/j.cgh.2015.04.173
NR 30
TC 22
Z9 22
U1 0
U2 6
PU FRONTLINE MEDICAL COMMUNICATIONS
PI THE WOODLANDS
PA WRIGHTS MEDIA, 2407 TIMBERLOCH PLACE, SUITE B, THE WOODLANDS, TX 77386
   USA
SN 1085-5629
EI 1558-0768
J9 SEMIN CUTAN MED SURG
JI Semin. Cutan. Med. Surg.
PD JUN
PY 2017
VL 36
IS 2
BP 55
EP 57
DI 10.12788/j.sder.2017.018
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EX6XY
UT WOS:000403386600004
PM 28538744
DA 2025-06-11
ER

PT J
AU Perry, BI
   Khandaker, GM
   Marwaha, S
   Thompson, A
   Zammit, S
   Singh, SP
   Upthegrove, R
AF Perry, B. I.
   Khandaker, G. M.
   Marwaha, S.
   Thompson, A.
   Zammit, S.
   Singh, S. P.
   Upthegrove, R.
TI Insulin resistance and obesity, and their association with depression in
   relatively young people: findings from a large UK birth cohort
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE ALSPAC; depression; inflammation; insulin resistance; obesity;
   overweight
ID METABOLIC SYNDROME; DIABETES PREVALENCE; PHYSICAL-ACTIVITY; BIPOLAR
   DISORDER; MAJOR DEPRESSION; SEX-DIFFERENCES; RISK; ADULTS; DYSLIPIDEMIA;
   INFLAMMATION
AB BackgroundDepression frequently co-occurs with disorders of glucose and insulin homeostasis (DGIH) and obesity. Low-grade systemic inflammation and lifestyle factors in childhood may predispose to DGIH, obesity and depression. We aim to investigate the cross-sectional and longitudinal associations among DGIH, obesity and depression, and to examine the effect of demographics, lifestyle factors and antecedent low-grade inflammation on such associations in young people.MethodsUsing the Avon Longitudinal Study of Parents and Children birth cohort, we used regression analyses to examine: (1) cross-sectional and (2) longitudinal associations between measures of DGIH [insulin resistance (IR); impaired glucose tolerance] and body mass index (BMI) at ages 9 and 18 years, and depression (depressive symptoms and depressive episode) at age 18 years and (3) whether sociodemographics, lifestyle factors or inflammation [interleukin-6 (IL-6) at age 9 years] confounded any such associations.ResultsWe included 3208 participants. At age 18 years, IR and BMI were positively associated with depression. These associations may be explained by sociodemographic and lifestyle factors. There were no longitudinal associations between DGIH/BMI and depression, and adjustment for IL-6 and C-reactive protein did not attenuate associations between IR/BMI and depression; however, the longitudinal analyses may have been underpowered.ConclusionsYoung people with depression show evidence of DGIH and raised BMI, which may be related to sociodemographic and lifestyle effects such as deprivation, smoking, ethnicity and gender. In future, studies with larger samples are required to confirm this. Preventative strategies for the poorer physical health outcomes associated with depression should focus on malleable lifestyle factors.
C1 [Perry, B. I.; Khandaker, G. M.] Univ Cambridge, Dept Psychiat, Cambridge, England.
   [Perry, B. I.; Khandaker, G. M.] Cambridgeshire & Peterborough Natl Hlth Serv Fdn, Cambridge, England.
   [Khandaker, G. M.] Natl Inst Hlth Res Cambridge Biomed Res Ctr, Cambridge, England.
   [Marwaha, S.; Upthegrove, R.] Univ Birmingham, Inst Mental Hlth, Birmingham, W Midlands, England.
   [Marwaha, S.] Birmingham & Solihull Mental Hlth Fdn NHS Trust, Birmingham, W Midlands, England.
   [Thompson, A.; Singh, S. P.] Coventry & Warwickshire Partnership NHS Trust, Coventry, W Midlands, England.
   [Thompson, A.; Singh, S. P.] Univ Warwick, Unit Mental Hlth & Wellbeing, Coventry, W Midlands, England.
   [Zammit, S.] Univ Bristol, Sch Social & Community Med, Ctr Acad Mental Hlth, Bristol, Avon, England.
   [Zammit, S.] Cardiff Univ, Inst Psychol Med & Clin Neurosci, Med Res Council Ctr Neuropsychiat Genet & Genom, Cardiff, Wales.
   [Upthegrove, R.] Birmingham Womens & Childrens NHS Trust, Early Intervent Serv, Birmingham, W Midlands, England.
C3 University of Cambridge; University of Birmingham; University of
   Warwick; University of Bristol; Cardiff University
RP Perry, BI (corresponding author), Univ Cambridge, Dept Psychiat, Cambridge, England.; Perry, BI (corresponding author), Cambridgeshire & Peterborough Natl Hlth Serv Fdn, Cambridge, England.
EM bip20@medschl.cam.ac.uk
RI Khandaker, Gulam/G-6171-2019; thompson, andrew/AAQ-8744-2020;
   Upthegrove, Rachel/AAD-9761-2022; Thompson, Andrew/F-3153-2012; Marwaha,
   Steven/G-4489-2013
OI Thompson, Andrew/0000-0002-0567-6013; Perry, Benjamin
   I./0000-0002-1533-026X; Khandaker, Golam/0000-0002-4935-9220; Marwaha,
   Steven/0000-0002-0303-9942; Upthegrove, Rachel/0000-0001-8204-5103
FU UK Medical Research Council [102215/2/13/2]; Wellcome Trust
   [102215/2/13/2, 08426812/Z/07/Z]; Coventry and Warwickshire Partnership
   NHS Trust Research Development Fund; National Institute for Health
   Research (NIHR Doctoral Research Fellowship) [DRF-2018-11-ST2-018];
   Wellcome Trust (Intermediate Clinical Fellowship) [201486/Z/16/Z]; MRC
   (MICA: Mental Health Data Pathfinder) [MC_PC_17213]; MQ: Transforming
   Mental Health (Data Science Award) [MQDS17/40]; MRC [MC_PC_17213,
   MC_PC_19009] Funding Source: UKRI; National Institutes of Health
   Research (NIHR) [DRF-2018-11-ST2-018] Funding Source: National
   Institutes of Health Research (NIHR)
FX The UK Medical Research Council and Wellcome Trust (Grant no.
   102215/2/13/2) and the University of Bristol provide core support for
   ALSPAC. This publication is the work of the authors, who will serve as
   guarantors for the contents of this paper. Funding for data access was
   obtained from Coventry and Warwickshire Partnership NHS Trust Research
   Development Fund. This report is independent research supported by the
   National Institute for Health Research (NIHR Doctoral Research
   Fellowship, Dr Benjamin Ian Perry, DRF-2018-11-ST2-018). The views
   expressed in this publication are those of the author(s) and not
   necessarily those of the NHS, the National Institute for Health Research
   or the Department of Health and Social Care. Dr Khandaker acknowledges
   funding support from the Wellcome Trust (Intermediate Clinical
   Fellowship; grant no. 201486/Z/16/Z), MRC (MICA: Mental Health Data
   Pathfinder; grant no. MC_PC_17213) and MQ: Transforming Mental Health
   (Data Science Award; grant no. MQDS17/40). A comprehensive list of
   grants funding is available on the ALSPAC website
   (http://www.bristol.ac.uk/alspac/external/documents/grantacknowledgement
   s.pdf/); this research was specifically funded by The Wellcome Trust
   (Grant no. 08426812/Z/07/Z).
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Ali S, 2006, DIABETIC MED, V23, P1165, DOI 10.1111/j.1464-5491.2006.01943.x
   Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   [Anonymous], 2014, OBESITY SILVER SP S2, V22, pS40
   Belgardt BF, 2010, P NATL ACAD SCI USA, V107, P6028, DOI 10.1073/pnas.1001796107
   Blazer DG, 2002, J PSYCHOSOM RES, V53, P913, DOI 10.1016/S0022-3999(02)00314-8
   Bowes L, 2015, LANCET PSYCHIAT, V2, P793, DOI 10.1016/S2215-0366(15)00164-9
   Boyd A, 2013, INT J EPIDEMIOL, V42, P111, DOI 10.1093/ije/dys064
   Cooney G., 2014, JAMA-J AM MED ASSOC, V311, P2432
   Dagenais GR, 2016, DIABETES CARE, V39, P780, DOI 10.2337/dc15-2338
   Dandona P, 2004, TRENDS IMMUNOL, V25, P4, DOI 10.1016/j.it.2003.10.013
   Davies SJC, 2016, PSYCHOL MED, V46, P73, DOI 10.1017/S003329171500149X
   DEFRONZO RA, 1991, DIABETES CARE, V14, P173, DOI 10.2337/diacare.14.3.173
   Del Boca FK, 2003, ADDICTION, V98, P1, DOI 10.1046/j.1359-6357.2003.00586.x
   Ding EL, 2006, JAMA-J AM MED ASSOC, V295, P1288, DOI 10.1001/jama.295.11.1288
   Dong YR, 2013, SPRINGERPLUS, V2, DOI 10.1186/2193-1801-2-222
   Ensling M, 2011, CARDIORENAL MED, V1, P67, DOI 10.1159/000322886
   Everson SA, 2002, J PSYCHOSOM RES, V53, P891, DOI 10.1016/S0022-3999(02)00303-3
   Firth J, 2018, WORLD PSYCHIATRY, V17, P365, DOI 10.1002/wps.20571
   Fraser A, 2013, INT J EPIDEMIOL, V42, P97, DOI 10.1093/ije/dys066
   Goldney RD, 2004, DIABETES CARE, V27, P1066, DOI 10.2337/diacare.27.5.1066
   Gore FM, 2011, LANCET, V377, P2093, DOI 10.1016/S0140-6736(11)60512-6
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Insel TR, 2003, JAMA-J AM MED ASSOC, V289, P3167, DOI 10.1001/jama.289.23.3167
   Jacka FN, 2010, AUST NZ J PSYCHIAT, V44, P435, DOI 10.3109/00048670903571598
   Jung UJ, 2014, INT J MOL SCI, V15, P6184, DOI 10.3390/ijms15046184
   Katon W, 2004, DIABETES CARE, V27, P914, DOI 10.2337/diacare.27.4.914
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   Khandaker GM, 2018, PSYCHOL MED, V48, P1514, DOI 10.1017/S0033291717003038
   Khandaker GM, 2018, BRAIN BEHAV IMMUN, V69, P264, DOI 10.1016/j.bbi.2017.11.020
   Khandaker GM, 2014, JAMA PSYCHIAT, V71, P1121, DOI 10.1001/jamapsychiatry.2014.1332
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Köhler CA, 2017, ACTA PSYCHIAT SCAND, V135, P373, DOI 10.1111/acps.12698
   Lee HJ, 2011, UK STAT US GROUP M 2
   Levy JC, 1998, DIABETES CARE, V21, P2191, DOI 10.2337/diacare.21.12.2191
   LEWIS G, 1992, PSYCHOL MED, V22, P465, DOI 10.1017/S0033291700030415
   Li CY, 2008, DIABETES CARE, V31, P105, DOI 10.2337/dc07-1154
   Lin KP, 2014, BIOL RES NURS, V16, P327, DOI 10.1177/1099800413500138
   Lloyd CE, 2018, DIABETIC MED, V35, P760, DOI 10.1111/dme.13611
   Lysy Z, 2008, DIABETIC MED, V25, P1133, DOI 10.1111/j.1464-5491.2008.02545.x
   Mangurian CV, 2018, DIABETES CARE, V41, pE119, DOI 10.2337/dc18-0425
   Menke A, 2014, ANN INTERN MED, V161, P328, DOI 10.7326/M14-0286
   Milaneschi Y, 2017, JAMA PSYCHIAT, V74, P1214, DOI 10.1001/jamapsychiatry.2017.3016
   Miller AH, 2016, NAT REV IMMUNOL, V16, P22, DOI 10.1038/nri.2015.5
   Molosankwe I, 2012, J AFFECT DISORDERS, V142, pS42, DOI 10.1016/S0165-0327(12)70008-3
   Nichols GA, 2003, DIABETES CARE, V26, P744, DOI 10.2337/diacare.26.3.744
   Ong KK, 2004, DIABETOLOGIA, V47, P1064, DOI 10.1007/s00125-004-1405-8
   Parekh A, 2017, HEALTHCARE-BASEL, V5, DOI 10.3390/healthcare5010005
   Peduzzi P, 1996, J CLIN EPIDEMIOL, V49, P1373, DOI 10.1016/S0895-4356(96)00236-3
   Perreault L, 2008, DIABETES CARE, V31, P1416, DOI 10.2337/dc07-2390
   Pickup JC, 2004, DIABETES CARE, V27, P813, DOI 10.2337/diacare.27.3.813
   Quarini C, 2016, J AFFECT DISORDERS, V189, P329, DOI 10.1016/j.jad.2015.09.039
   Rader DJ, 2007, AM J MED, V120, pS12, DOI 10.1016/j.amjmed.2007.01.003
   Roy T, 2012, J AFFECT DISORDERS, V142, pS8, DOI 10.1016/S0165-0327(12)70004-6
   Sallis JF, 2000, RES Q EXERCISE SPORT, V71, pS1, DOI 10.1080/02701367.2000.11082780
   Schuch FB, 2016, J PSYCHIATR RES, V77, P42, DOI 10.1016/j.jpsychires.2016.02.023
   Schuch FB, 2016, NEUROSCI BIOBEHAV R, V61, P1, DOI 10.1016/j.neubiorev.2015.11.012
   Shipton D, 2009, BMJ-BRIT MED J, V339, DOI 10.1136/bmj.b4347
   Slopen N, 2013, PSYCHONEUROENDOCRINO, V38, P188, DOI 10.1016/j.psyneuen.2012.05.013
   Tamayo T, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-525
   Tann SS, 2007, AM INDIAN ALASKA NAT, V14, P1
   Teasdale SB, 2017, BRIT J PSYCHIAT, V210, P110, DOI 10.1192/bjp.bp.115.177139
   Timonen M, 2006, MOL PSYCHIATR, V11, P929, DOI 10.1038/sj.mp.4001838
   Vancampfort D, 2017, WORLD PSYCHIATRY, V16, P308, DOI 10.1002/wps.20458
   Vancampfort D, 2016, WORLD PSYCHIATRY, V15, P166, DOI 10.1002/wps.20309
   Wallace TM, 2004, DIABETES CARE, V27, P1487, DOI 10.2337/diacare.27.6.1487
   White IR, 2011, STAT MED, V30, P377, DOI 10.1002/sim.4067
NR 67
TC 25
Z9 28
U1 1
U2 17
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD MAR
PY 2020
VL 50
IS 4
BP 556
EP 565
DI 10.1017/S0033291719000308
PG 10
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA LI4CW
UT WOS:000529434200003
PM 30854996
OA Green Submitted, Green Published, Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Ferreira, DMS
   Simao, AL
   Rodrigues, CMP
   Castro, RE
AF Ferreira, Duarte M. S.
   Simao, Andre L.
   Rodrigues, Cecilia M. P.
   Castro, Rui E.
TI Revisiting the metabolic syndrome and paving the way for microRNAs in
   non-alcoholic fatty liver disease
SO FEBS JOURNAL
LA English
DT Review
DE apoptosis biomarkers; ER stress; gut microbiota; insulin resistance;
   metabolism; miRNAs; NAFLD; oxidative stress
ID ENDOPLASMIC-RETICULUM STRESS; TYROSINE-PHOSPHATASE 1B;
   NECROSIS-FACTOR-ALPHA; DIET-INDUCED OBESITY; NF-KAPPA-B;
   INSULIN-RESISTANCE; HEPATIC STEATOSIS; GUT MICROBIOTA;
   GENERAL-POPULATION; DOWN-REGULATION
AB Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of stages from simple steatosis to non-alcoholic steatohepatitis, which can progress to fibrosis, cirrhosis and, ultimately, hepatocellular carcinoma. Despite being one of the most common chronic liver diseases, NAFLD pathogenesis remains largely unknown. In this review, we discuss the key molecular mechanisms involved in NAFLD development and progression, focusing on the emerging role of microRNAs. NAFLD is intrinsically related to obesity and the metabolic syndrome. Changes in lipid metabolism increase free fatty acids in blood, which in turn induces peripheral insulin resistance and increases oxidative and endoplasmic reticulum stress. Although not yet considered in the diagnosis of NAFLD, recent reports also reinforce the crucial role of apoptosis in disease progression via activation of either death receptor or mitochondrial pathways and p53. In addition, the role of gut microbiota and the gut-liver axis has been recently associated with NAFLD. Finally, there is an accumulating and growing body of evidence supporting the role of microRNAs in NAFLD pathogenesis and progression, as well as hinting at their use as biomarkers or therapeutic tools. The ultimate goal is to review different molecular pathways that may underlie NAFLD pathogenesis in the hope of finding targets for new and efficient therapeutic interventions.
C1 [Ferreira, Duarte M. S.; Simao, Andre L.; Rodrigues, Cecilia M. P.; Castro, Rui E.] Univ Lisbon, Fac Farm, Inst Invest Medicamento iMed ULisboa, P-1649003 Lisbon, Portugal.
   [Rodrigues, Cecilia M. P.; Castro, Rui E.] Univ Lisbon, Fac Farm, Dept Biochem & Human Biol, P-1649003 Lisbon, Portugal.
C3 Universidade de Lisboa; Universidade de Lisboa
RP Castro, RE (corresponding author), Univ Lisbon, Fac Farm, Inst Invest Medicamento iMed ULisboa, Av Prof Gama Pinto, P-1649003 Lisbon, Portugal.
EM ruieduardocastro@ff.ul.pt
RI Castro, Rui/AAG-4179-2021; Castro, Rui/I-2975-2013; Sacramento Ferreira,
   Duarte Miguel/E-4270-2012; Simao, Andre/M-9767-2018; Pereira Rodrigues,
   Cecilia Maria/M-3572-2013
OI Castro, Rui/0000-0002-7417-0091; Sacramento Ferreira, Duarte
   Miguel/0000-0001-5940-7102; Simao, Andre/0000-0002-5986-1089; Pereira
   Rodrigues, Cecilia Maria/0000-0002-4829-754X
FU Fundacao para a Ciencia e a Tecnologia [PTDC/SAU-ORG/111930/2009,
   PTDC/BIM-MEC/0873/2012]; FCT, Lisbon, Portugal [SFRH/BD/60521/2009];
   Fundação para a Ciência e a Tecnologia [PTDC/BIM-MEC/0873/2012,
   PTDC/SAU-ORG/111930/2009, SFRH/BD/60521/2009] Funding Source: FCT
FX Supported by grants from Fundacao para a Ciencia e a Tecnologia
   PTDC/SAU-ORG/111930/2009 and PTDC/BIM-MEC/0873/2012. D. M. S. F. was
   awarded fellowship SFRH/BD/60521/2009 from FCT, Lisbon, Portugal. The
   authors apologize to those authors whose work they have not been able to
   cite as a result of limited space. The authors also thank all members of
   the laboratory for insightful discussions.
CR Abu-Shanab A, 2010, NAT REV GASTRO HEPAT, V7, P691, DOI 10.1038/nrgastro.2010.172
   Ahn J, 2011, BIOCHEM BIOPH RES CO, V414, P664, DOI 10.1016/j.bbrc.2011.09.120
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alisi A, 2011, LAB INVEST, V91, P283, DOI 10.1038/labinvest.2010.166
   Allen RM, 2012, EMBO MOL MED, V4, P882, DOI 10.1002/emmm.201201228
   Arroyo JD, 2011, P NATL ACAD SCI USA, V108, P5003, DOI 10.1073/pnas.1019055108
   Ayonrinde OT, 2011, HEPATOLOGY, V53, P800, DOI 10.1002/hep.24097
   Bäckhed F, 2005, SCIENCE, V307, P1915, DOI 10.1126/science.1104816
   Bäckhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   Bader Andreas G., 2012, Frontiers in Genetics, V3, P120, DOI 10.3389/fgene.2012.00120
   Bajaj M, 2004, INT J OBESITY, V28, P783, DOI 10.1038/sj.ijo.0802625
   Bandyopadhyay GK, 2005, DIABETES, V54, P2351, DOI 10.2337/diabetes.54.8.2351
   Barreyro FJ, 2007, J BIOL CHEM, V282, P27141, DOI 10.1074/jbc.M704391200
   Bartel DP, 2009, CELL, V136, P215, DOI 10.1016/j.cell.2009.01.002
   Baumeister SE, 2008, GASTROENTEROLOGY, V134, P85, DOI 10.1053/j.gastro.2007.10.024
   Bedogni G, 2007, HEPATOLOGY, V46, P1387, DOI 10.1002/hep.21827
   Bellentani S, 2010, DIGEST DIS, V28, P155, DOI 10.1159/000282080
   Bertolotti A, 2000, NAT CELL BIOL, V2, P326, DOI 10.1038/35014014
   Blachier M, 2013, J HEPATOL, V58, P593, DOI 10.1016/j.jhep.2012.12.005
   Bobrovnikova-Marjon E, 2008, P NATL ACAD SCI USA, V105, P16314, DOI 10.1073/pnas.0808517105
   Borradaile NM, 2006, J LIPID RES, V47, P2726, DOI 10.1194/jlr.M600299-JLR200
   Bravo R, 2011, J CELL SCI, V124, P2143, DOI 10.1242/jcs.080762
   Broderick JA, 2011, GENE THER, V18, P1104, DOI 10.1038/gt.2011.50
   Bugianesi E, 2005, HEPATOLOGY, V42, P987, DOI 10.1002/hep.20920
   Cai DS, 2005, NAT MED, V11, P183, DOI 10.1038/nm1166
   Caldwell Stephen H, 2004, Clin Liver Dis, V8, P595, DOI 10.1016/j.cld.2004.04.009
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Care A, 2007, NAT MED, V13, P613, DOI 10.1038/nm1582
   Carthew RW, 2009, CELL, V136, P642, DOI 10.1016/j.cell.2009.01.035
   Castellares C, 2008, J VIRAL HEPATITIS, V15, P165, DOI 10.1111/j.1365-2893.2007.00903.x
   Castro RE, 2013, J HEPATOL, V58, P119, DOI 10.1016/j.jhep.2012.08.008
   Cazanave SC, 2011, J LIPID RES, V52, P1517, DOI 10.1194/jlr.M014654
   Cazanave SC, 2009, J BIOL CHEM, V284, P26591, DOI 10.1074/jbc.M109.022491
   Cermelli S, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023937
   Cheung O, 2008, HEPATOLOGY, V48, P1810, DOI 10.1002/hep.22569
   Chitturi S, 2002, HEPATOLOGY, V36, P403, DOI 10.1053/jhep.2002.34738
   Choi SE, 2013, AGING CELL, V12, P1062, DOI 10.1111/acel.12135
   Clarke JD, 2014, J APPL TOXICOL, V34, P726, DOI 10.1002/jat.2960
   Cohen JC, 2011, SCIENCE, V332, P1519, DOI 10.1126/science.1204265
   Copps KD, 2010, CELL METAB, V11, P84, DOI 10.1016/j.cmet.2009.11.003
   Cortez MA, 2011, NAT REV CLIN ONCOL, V8, P467, DOI 10.1038/nrclinonc.2011.76
   Csak T, 2011, HEPATOLOGY, V54, P133, DOI 10.1002/hep.24341
   Dávalos A, 2011, P NATL ACAD SCI USA, V108, P9232, DOI 10.1073/pnas.1102281108
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   de La Serre CB, 2010, AM J PHYSIOL-GASTR L, V299, pG440, DOI 10.1152/ajpgi.00098.2010
   Delibegovic M, 2009, DIABETES, V58, P590, DOI 10.2337/db08-0913
   Derdak Z, 2013, J HEPATOL, V58, P785, DOI 10.1016/j.jhep.2012.11.042
   Derdak Z, 2011, J HEPATOL, V54, P164, DOI 10.1016/j.jhep.2010.08.007
   Dolganiuc A, 2009, ALCOHOL CLIN EXP RES, V33, P1704, DOI 10.1111/j.1530-0277.2009.01007.x
   Ebert MS, 2007, NAT METHODS, V4, P721, DOI 10.1038/NMETH1079
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Elliott MR, 2009, NATURE, V461, P282, DOI 10.1038/nature08296
   Fabian MR, 2010, ANNU REV BIOCHEM, V79, P351, DOI 10.1146/annurev-biochem-060308-103103
   Farrell GC, 2009, J GASTROEN HEPATOL, V24, P443, DOI 10.1111/j.1440-1746.2009.05785.x
   Feldstein AE, 2004, HEPATOLOGY, V40, P185, DOI 10.1002/hep.20283
   Ferreira DMS, 2011, DIABETOLOGIA, V54, P1788, DOI 10.1007/s00125-011-2130-8
   Ferreira DMS, 2014, MOL CELL BIOL, V34, P1100, DOI 10.1128/MCB.00420-13
   Frith J, 2009, GERONTOLOGY, V55, P607, DOI 10.1159/000235677
   Fu T, 2012, P NATL ACAD SCI USA, V109, P16137, DOI 10.1073/pnas.1205951109
   Gao ZG, 2002, J BIOL CHEM, V277, P48115, DOI 10.1074/jbc.M209459200
   García-Ruiz I, 2006, HEPATOLOGY, V44, P581, DOI 10.1002/hep.21313
   Gastaldelli A, 2007, GASTROENTEROLOGY, V133, P496, DOI 10.1053/j.gastro.2007.04.068
   Gavrilova O, 2003, J BIOL CHEM, V278, P34268, DOI 10.1074/jbc.M300043200
   Ghosh Sumona, 2010, Hepat Med, V2010, P69
   Hanke M, 2010, UROL ONCOL-SEMIN ORI, V28, P655, DOI 10.1016/j.urolonc.2009.01.027
   Harding HP, 2001, MOL CELL, V7, P1153, DOI 10.1016/S1097-2765(01)00264-7
   Haring R, 2009, HEPATOLOGY, V50, P1403, DOI 10.1002/hep.23135
   Henao-Mejia J, 2013, J AUTOIMMUN, V46, P66, DOI 10.1016/j.jaut.2013.07.001
   Henao-Mejia J, 2012, NATURE, V482, P179, DOI 10.1038/nature10809
   Hetz C, 2012, NAT REV MOL CELL BIO, V13, P89, DOI 10.1038/nrm3270
   Hildebrandt-Eriksen ES, 2012, NUCLEIC ACID THER, V22, P152, DOI 10.1089/nat.2011.0332
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Hoekstra M, 2012, J NUTR BIOCHEM, V23, P622, DOI 10.1016/j.jnutbio.2011.03.005
   Horie T, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3883
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Hsu SH, 2012, J CLIN INVEST, V122, P2871, DOI 10.1172/JCI63539
   Hu P, 2006, MOL CELL BIOL, V26, P3071, DOI 10.1128/MCB.26.8.3071-3084.2006
   Hui JM, 2004, HEPATOLOGY, V40, P46, DOI 10.1002/hep.20280
   Hunter MP, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003694
   Kitamura T, 1999, MOL CELL BIOL, V19, P6286
   Kleiner DE, 2012, SEMIN LIVER DIS, V32, P3, DOI 10.1055/s-0032-1306421
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Koehler EM, 2012, J HEPATOL, V57, P1305, DOI 10.1016/j.jhep.2012.07.028
   Kota J, 2009, CELL, V137, P1005, DOI 10.1016/j.cell.2009.04.021
   Krishnan N, 2011, SCI SIGNAL, V4, DOI 10.1126/scisignal.2002329
   Krützfeldt J, 2005, NATURE, V438, P685, DOI 10.1038/nature04303
   Krützfeldt J, 2007, NUCLEIC ACIDS RES, V35, P2885, DOI 10.1093/nar/gkm024
   Lanford RE, 2010, SCIENCE, V327, P198, DOI 10.1126/science.1178178
   Lee J, 2010, J BIOL CHEM, V285, P12604, DOI 10.1074/jbc.M109.094524
   Li J, 2012, ANTIOXID REDOX SIGN, V17, P1083, DOI 10.1089/ars.2011.4417
   Li SJ, 2009, J LIPID RES, V50, P1756, DOI 10.1194/jlr.M800509-JLR200
   Li TG, 2013, HEPATOLOGY, V58, P1111, DOI 10.1002/hep.26427
   Li ZZ, 2009, J BIOL CHEM, V284, P5637, DOI 10.1074/jbc.M807616200
   Liang Y, 2007, BMC GENOMICS, V8, DOI 10.1186/1471-2164-8-166
   Lin JH, 2007, SCIENCE, V318, P944, DOI 10.1126/science.1146361
   Loh K, 2009, CELL METAB, V10, P260, DOI 10.1016/j.cmet.2009.08.009
   Lomonaco R, 2012, HEPATOLOGY, V55, P1389, DOI 10.1002/hep.25539
   Machado MV, 2012, ANN HEPATOL, V11, P440, DOI 10.1016/S1665-2681(19)31457-7
   Machado MV, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031738
   Malhi H, 2006, J BIOL CHEM, V281, P12093, DOI 10.1074/jbc.M510660200
   Marí M, 2006, CELL METAB, V4, P185, DOI 10.1016/j.cmet.2006.07.006
   Merry TL, 2014, ANTIOXID REDOX SIGN, V20, P2114, DOI 10.1089/ars.2013.5428
   Miki H, 2012, J BIOCHEM, V151, P255, DOI 10.1093/jb/mvs006
   Miller AM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0072324
   Min HK, 2012, CELL METAB, V15, P665, DOI 10.1016/j.cmet.2012.04.004
   Miura K, 2013, HEPATOLOGY, V57, P577, DOI 10.1002/hep.26081
   Musso G, 2005, AM J GASTROENTEROL, V100, P2438, DOI 10.1111/j.1572-0241.2005.00297.x
   Najafi-Shoushtari SH, 2010, SCIENCE, V328, P1566, DOI 10.1126/science.1189123
   Najjar SM, 2014, SEMIN IMMUNOPATHOL, V36, P55, DOI 10.1007/s00281-013-0407-3
   Ogawa T, 2012, GUT, V61, P1600, DOI 10.1136/gutjnl-2011-300717
   Ogawa W, 2008, SCIENCE, V322, P1483, DOI 10.1126/science.1167571
   Omary MB, 2009, J CLIN INVEST, V119, P1794, DOI 10.1172/JCI37762
   Östman A, 2011, J BIOCHEM, V150, P345, DOI 10.1093/jb/mvr104
   Owen C, 2013, DIABETOLOGIA, V56, P2286, DOI 10.1007/s00125-013-2992-z
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Pajunen P, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-754
   Panzhinskiy E, 2013, CURR MED CHEM, V20, P2609, DOI 10.2174/0929867311320210001
   Pérez-Carreras M, 2003, HEPATOLOGY, V38, P999, DOI 10.1053/jhep.2003.50398
   Pogribny IP, 2010, LAB INVEST, V90, P1437, DOI 10.1038/labinvest.2010.113
   Previs SF, 2000, J BIOL CHEM, V275, P38990, DOI 10.1074/jbc.M006490200
   Purushotham A, 2009, CELL METAB, V9, P327, DOI 10.1016/j.cmet.2009.02.006
   Ramalho RM, 2006, EUR J GASTROEN HEPAT, V18, P21, DOI 10.1097/00042737-200601000-00005
   Rayner KJ, 2011, NATURE, V478, P404, DOI 10.1038/nature10486
   Rayner KJ, 2011, J CLIN INVEST, V121, P2921, DOI 10.1172/JCI57275
   Ribeiro PS, 2004, AM J GASTROENTEROL, V99, P1708, DOI 10.1111/j.1572-0241.2004.40009.x
   Roberts J, 2006, MOL THER, V14, P471, DOI 10.1016/j.ymthe.2006.05.017
   Rolo AP, 2012, FREE RADICAL BIO MED, V52, P59, DOI 10.1016/j.freeradbiomed.2011.10.003
   Saltiel AR, 2001, NATURE, V414, P799, DOI 10.1038/414799a
   Sánchez-Alcázar JA, 2003, BIOCHEM J, V370, P609, DOI 10.1042/BJ20021623
   Sarasin-Filipowicz M, 2009, NAT MED, V15, P31, DOI 10.1038/nm.1902
   Sayed D, 2008, MOL BIOL CELL, V19, P3272, DOI 10.1091/mbc.E08-02-0159
   Sayed D, 2011, PHYSIOL REV, V91, P827, DOI 10.1152/physrev.00006.2010
   Sharma H, 2013, J GASTROEN HEPATOL, V28, P1410, DOI 10.1111/jgh.12268
   Singh R, 2009, HEPATOLOGY, V49, P87, DOI 10.1002/hep.22578
   Song KH, 2010, J LIPID RES, V51, P2223, DOI 10.1194/jlr.M004531
   Tabas I, 2011, NAT CELL BIOL, V13, P184, DOI 10.1038/ncb0311-184
   Targher G, 2007, DIABETES CARE, V30, P1212, DOI 10.2337/dc06-2247
   Tiganis T, 2013, FEBS J, V280, P445, DOI 10.1111/j.1742-4658.2012.08563.x
   Tomita K, 2014, HEPATOLOGY, V59, P154, DOI 10.1002/hep.26604
   Tryndyak VP, 2012, TOXICOL APPL PHARM, V262, P52, DOI 10.1016/j.taap.2012.04.018
   Tsai WC, 2012, J CLIN INVEST, V122, P2884, DOI 10.1172/JCI63455
   Tsai Yien Che, 2010, Genes Cancer, V1, P764
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Usui M, 2012, METABOLISM, V61, P1118, DOI 10.1016/j.metabol.2012.01.004
   Vickers KC, 2011, NAT CELL BIOL, V13, P423, DOI 10.1038/ncb2210
   Vinciguerra M, 2009, HEPATOLOGY, V49, P1176, DOI 10.1002/hep.22737
   Voinnet O, 2009, CELL, V136, P669, DOI 10.1016/j.cell.2009.01.046
   Wang B, 2009, HEPATOLOGY, V50, P1152, DOI 10.1002/hep.23100
   Wang D, 2006, ENDOCRINOLOGY, V147, P943, DOI 10.1210/en.2005-0570
   Wang XL, 2011, BIOCHEM J, V435, P285, DOI 10.1042/BJ20101864
   Wang XM, 2013, J CONTROL RELEASE, V172, P690, DOI 10.1016/j.jconrel.2013.09.027
   Wang Y, 2008, J NUTR, V138, P1866, DOI 10.1093/jn/138.10.1866
   Watanabe S, 2005, HEPATOL RES, V33, P161, DOI 10.1016/j.hepres.2005.09.026
   Wen HT, 2011, NAT IMMUNOL, V12, P408, DOI 10.1038/ni.2022
   Wigg AJ, 2001, GUT, V48, P206, DOI 10.1136/gut.48.2.206
   Williamson RM, 2011, DIABETES CARE, V34, P1139, DOI 10.2337/dc10-2229
   Yamada H, 2013, CLIN CHIM ACTA, V424, P99, DOI 10.1016/j.cca.2013.05.021
   Yamamoto K, 2010, MOL BIOL CELL, V21, P2975, DOI 10.1091/mbc.E09-02-0133
   Yamaura Y, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030250
   Ye J, 2000, MOL CELL, V6, P1355, DOI 10.1016/S1097-2765(00)00133-7
   Yoshimoto S, 2013, NATURE, V499, P97, DOI 10.1038/nature12347
   Yoshizaki T, 2009, MOL CELL BIOL, V29, P1363, DOI 10.1128/MCB.00705-08
   You Y, 2006, NUCLEIC ACIDS RES, V34, DOI 10.1093/nar/gkl175
   Zhang H, 2012, WORLD J GASTROENTERO, V18, P5188, DOI 10.3748/wjg.v18.i37.5188
   Zhang KZ, 2011, EMBO J, V30, P1357, DOI 10.1038/emboj.2011.52
   Zhang W, 2006, CELL METAB, V4, P491, DOI 10.1016/j.cmet.2006.11.002
   Zhang Y, 2010, CLIN CHEM, V56, P1830, DOI 10.1373/clinchem.2010.147850
   Zhang YH, 2013, DIABETES RES CLIN PR, V99, P327, DOI 10.1016/j.diabres.2012.11.025
   Zheng L, 2010, J GASTROEN HEPATOL, V25, P156, DOI 10.1111/j.1440-1746.2009.05949.x
   Zhong D, 2013, CELL SIGNAL, V25, P1429, DOI 10.1016/j.cellsig.2013.03.003
NR 170
TC 55
Z9 58
U1 0
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-464X
EI 1742-4658
J9 FEBS J
JI FEBS J.
PD JUN
PY 2014
VL 281
IS 11
BP 2503
EP 2524
DI 10.1111/febs.12806
PG 22
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA AJ4VJ
UT WOS:000337676100002
PM 24702768
OA Bronze
DA 2025-06-11
ER

PT J
AU Kaiser, A
   Schaefer, SM
   Behrendt, I
   Eichner, G
   Fasshauer, M
AF Kaiser, Anna
   Schaefer, Sylva M.
   Behrendt, Inken
   Eichner, Gerrit
   Fasshauer, Mathias
TI Association of sugar intake from different sources with incident
   depression in the prospective cohort of UK Biobank participants
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Carbohydrates; Depression; Metabolic syndrome; Sugar; UK Biobank
ID LOW-CARBOHYDRATE; NEUROTROPHIC FACTOR; WEIGHT-LOSS; RISK; DIET;
   CONSUMPTION; FAT; LIQUID; INDEX; FOODS
AB Purpose To elucidate the association of different sources of free sugars (FS) and intrinsic sugars with depression risk in the prospective population-based UK Biobank cohort. Methods Sugar consumption was assessed in 188,426 participants (age range: 39-72 years, 54.4% female) with at least one web-based dietary questionnaire (Oxford WebQ). The hazard ratios (HR) for incident depression were assessed with Cox proportional hazard regression models including sugar intake from different sources as penalized cubic splines to allow non-linear predictor effects. Over a mean follow-up of 12.3 (standard deviation 1.8) years, 5410 incident depression cases occurred. Results FS intake was significantly associated with depression risk in an ascending approximately linear way with the lowest HR observed at 9% total energy (%E). In contrast, consumption of intrinsic sugars was not significantly related with incident depression. FS in beverages were significantly associated with depression risk in an ascending approximately linear way with the lowest HR at 4%E whereas no association was found for FS in solids. Concerning beverage types, FS in soda/fruit drinks, milk-based drinks, and tea/coffee were significantly and positively related to depression risk whereas the association was U-shaped for juice. Major findings were robust in sensitivity analyses. Conclusion Only some sources of FS are positively associated with incident depression. Public health initiatives targeting FS subtypes might be most effective concerning depression risk if focused on the reduction of sugary beverages and more specifically soda/fruit drinks, milk-based drinks, and tea/coffee.
C1 [Kaiser, Anna; Schaefer, Sylva M.; Behrendt, Inken; Fasshauer, Mathias] Justus Liebig Univ Giessen, Inst Nutr Sci, D-35390 Giessen, Germany.
   [Eichner, Gerrit] Justus Liebig Univ Giessen, Math Inst, Giessen, Germany.
   [Fasshauer, Mathias] Univ Leipzig, Dept Internal Med Endocrinol Nephrol & Rheumatol, Leipzig, Germany.
C3 Justus Liebig University Giessen; Justus Liebig University Giessen;
   Leipzig University
RP Kaiser, A (corresponding author), Justus Liebig Univ Giessen, Inst Nutr Sci, D-35390 Giessen, Germany.
EM anna.kaiser@ernaehrung.uni-giessen.de
RI Schaefer, Sylva Mareike/KWT-4078-2024
OI Kaiser, Anna/0000-0003-1705-6994; Schaefer, Sylva
   Mareike/0000-0001-5949-3282
FU Deutsche Forschungsgemeinschaft (DFG) [SFB 1052/2 C6]; Deutsche Diabetes
   Stiftung; Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL. This work was
   supported by the Deutsche Forschungsgemeinschaft (DFG) (SFB 1052/2 C6)
   and the Deutsche Diabetes Stiftung to MF. The funders had no role in the
   design, analysis, or writing of this article, and the decision to
   submit.
CR Achour L, 2001, EUR J CLIN NUTR, V55, P769, DOI 10.1038/sj.ejcn.1601221
   Agostoni C, 2010, EFSA J, V8, DOI 10.2903/j.efsa.2010.1462
   Al-Khatib Y, 2022, CUREUS J MED SCIENCE, V14, DOI 10.7759/cureus.22153
   Amoutzopoulos B, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020393
   Anderson JJ, 2020, BMC MED, V18, DOI 10.1186/s12916-020-01554-5
   [Anonymous], 2002, Food Portion Sizes, V3rd
   [Anonymous], 2015, Guideline: sugars intake for adults and children
   Avena NM, 2008, NEUROSCI BIOBEHAV R, V32, P20, DOI 10.1016/j.neubiorev.2007.04.019
   Barber TM, 2021, NUTRIENTS, V13, DOI 10.3390/nu13041187
   Behrendt I, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9121287
   Behrendt I, 2021, EUR J NUTR, V60, P1547, DOI 10.1007/s00394-020-02351-9
   Calder PC, 2011, BRIT J NUTR, V106, pS1, DOI 10.1017/S0007114511005460
   Chapman KennethW., 2021, Grime2
   Foster GD, 2010, ANN INTERN MED, V153, P147, DOI 10.7326/0003-4819-153-3-201008030-00005
   Fry A, 2017, AM J EPIDEMIOL, V186, P1026, DOI 10.1093/aje/kwx246
   Gangwisch JE, 2015, AM J CLIN NUTR, V102, P454, DOI 10.3945/ajcn.114.103846
   Guo XG, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094715
   Halyburton AK, 2007, AM J CLIN NUTR, V86, P580, DOI 10.1093/ajcn/86.3.580
   Henry CJK, 2005, PUBLIC HEALTH NUTR, V8, P1133, DOI 10.1079/PHN2005801
   Kashino I, 2021, NUTRITION, V81, DOI 10.1016/j.nut.2020.110860
   Knüppel A, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-05649-7
   Lassale C, 2019, MOL PSYCHIATR, V24, P965, DOI 10.1038/s41380-018-0237-8
   Lee AK, 2015, OBES SCI PRACT, V1, P41, DOI 10.1002/osp4.7
   Liu B, 2011, PUBLIC HEALTH NUTR, V14, P1998, DOI 10.1017/S1368980011000942
   Molteni R, 2002, NEUROSCIENCE, V112, P803, DOI 10.1016/S0306-4522(02)00123-9
   Morenga LT, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.e7492
   MRC Human Nutrition Research, 2017, FOOD STAND AG STAND, DOI 10.5255/UKDA-SN-8159-1
   National Institute of Mental Health, 2018, Depression
   NHS, 2020, Sugar: the facts
   Norwitz NG, 2020, CURR OPIN ENDOCRINOL, V27, P269, DOI 10.1097/MED.0000000000000564
   Osimo EF, 2019, PSYCHOL MED, V49, P1958, DOI 10.1017/S0033291719001454
   Park M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061815
   Patsalos O, 2021, J PERS MED, V11, DOI 10.3390/jpm11030176
   Raats M. M., 1992, Food Quality and Preference, V3, P89, DOI 10.1016/0950-3293(91)90028-D
   Rahe C, 2014, EUR J NUTR, V53, P997, DOI 10.1007/s00394-014-0652-9
   Ranawana V, 2011, INT J FOOD SCI NUTR, V62, P71, DOI 10.3109/09637486.2010.520011
   Saghafian F, 2018, BRIT J NUTR, V119, P1087, DOI 10.1017/S0007114518000697
   Salari-Moghaddam A, 2019, EUR J CLIN NUTR, V73, P356, DOI 10.1038/s41430-018-0258-z
   Sanchez-Villegas A, 2018, BRIT J NUTR, V119, P211, DOI 10.1017/S0007114517003361
   Sánchez-Villegas A, 2012, PUBLIC HEALTH NUTR, V15, P424, DOI 10.1017/S1368980011001856
   Schaefer SM, 2023, BRIT J NUTR, V129, P115, DOI 10.1017/S000711452200040X
   Schaefer SM, 2022, BRAIN SCI, V12, DOI 10.3390/brainsci12030360
   Sen S, 2008, BIOL PSYCHIAT, V64, P527, DOI 10.1016/j.biopsych.2008.05.005
   Shai I, 2008, NEW ENGL J MED, V359, P229, DOI 10.1056/NEJMoa0708681
   Shimmura N, 2022, BRIT J NUTR, V128, P139, DOI 10.1017/S0007114521003056
   Tasevska N, 2015, NUTRIENTS, V7, P5816, DOI 10.3390/nu7075255
   UK Biobank, 2019, 1 OCCURRENCE HLTH OU
   UK Biobank, 2020, UK BIOB BRAIN IM ACQ
   Wanselius J, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061342
   Werneck AO, 2021, BRAZ J PSYCHIAT, V43, P574, DOI 10.1590/1516-4446-2020-1073
   Willett WC, 1997, AM J CLIN NUTR, V65, P1220, DOI 10.1093/ajcn/65.4.1220S
NR 51
TC 6
Z9 6
U1 1
U2 15
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD MAR
PY 2023
VL 62
IS 2
BP 727
EP 738
DI 10.1007/s00394-022-03022-7
EA OCT 2022
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 9E6LN
UT WOS:000864960200001
PM 36205767
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Wu, YT
   Wu, SB
   Wei, YH
AF Wu, Y. -T.
   Wu, S. -B.
   Wei, Y. -H.
TI Roles of sirtuins in the regulation of antioxidant defense and
   bioenergetic function of mitochondria under oxidative stress
SO FREE RADICAL RESEARCH
LA English
DT Review
DE mitochondria; reactive oxygen species; Aging; metabolic syndrome;
   oxidative stress; insulin
ID FATTY-ACID OXIDATION; CARDIAC GLUCOSE-OXIDATION; MEDIATED CELL-DEATH;
   4977 BP DELETION; CALORIE RESTRICTION; SIRT3 DEACETYLATES;
   SKELETAL-MUSCLE; METABOLIC SYNDROME; MALONYL-COA; SIRT3-MEDIATED
   DEACETYLATION
AB In addition to serving as the power house of mammalian cells, mitochondria are crucial for the maintenance of cellular homeostasis in response to physiological or environmental changes. Several lines of evidence suggest that posttranslational modifi cation (PTM) of proteins plays a pivotal role in the regulation of the bioenergetic function of mitochondria. Among them, reversible lysine acetylation of mitochondrial proteins has been established as one of the key mechanisms in cellular response to energy demand by modulating the flux of a number of key metabolic pathways. In this article, we focus on the role of Sirt3-mediated deacetylation in: (1) flexibility of energy metabolism, (2) activation of antioxidant defense, and (3) maintenance of cellular redox status in response to dietary challenge and oxidative stress. We suggest that oxidative stress-elicited down-regulation of Sirt3 plays a role in the pathophysiology of diabetes, cardiac hypotrophy, mitochondrial diseases, and age-related diseases. Besides, the physiological role of newly identified lysine acylation mediated by Sirt5 and its biochemical effects on oxidative metabolism are also discussed. Moreover, we have integrated the regulatory function of several protein kinases that are involved in the phosphorylation of mitochondrial enzymes during oxidative stress. Finally, the functional consequence of the synergistic regulation through diverse protein modifi cations is emphasized on the maintenance of the bioenergetic homeostasis and metabolic adaptation of the animal and human cells. Together, we have provided an updated review of PTM in mitochondrial biology and their implications in aging and human diseases through an intricate regulation of energy metabolism under oxidative stress.
C1 [Wu, Y. -T.; Wu, S. -B.; Wei, Y. -H.] Mackay Med Coll, Dept Med, New Taipei City 252, Taiwan.
   [Wei, Y. -H.] Natl Yang Ming Univ, Sch Life Sci, Dept Biochem & Mol Biol, Taipei 112, Taiwan.
C3 Mackay Medical College; National Yang Ming Chiao Tung University
RP Wei, YH (corresponding author), Mackay Med Coll, Dept Med, New Taipei City 252, Taiwan.
EM joeman@mmc.edu.tw
RI Wei, Yau-Huei/ABA-6841-2021; TMU, barry0110/AAV-4030-2021
OI Wei, Yau-Huei/0000-0002-6429-2546
FU Mackay Medical College [982A01]
FX The authors would like to acknowledge the support of an intramural
   research grant 982A01 from Mackay Medical College.
CR Ahn BH, 2008, P NATL ACAD SCI USA, V105, P14447, DOI 10.1073/pnas.0803790105
   Akieda-Asai S, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011755
   Allali-Hassani A, 2009, BIOCHEM J, V424, P15, DOI 10.1042/BJ20090723
   Anderson EJ, 2009, J CLIN INVEST, V119, P573, DOI 10.1172/JCI37048
   Balaban RS, 2005, CELL, V120, P483, DOI 10.1016/j.cell.2005.02.001
   Bandyopadhyay GK, 2006, DIABETES, V55, P2277, DOI 10.2337/db06-0062
   Bao JJ, 2010, FREE RADICAL BIO MED, V49, P1230, DOI 10.1016/j.freeradbiomed.2010.07.009
   Bellizzi D, 2005, GENOMICS, V85, P258, DOI 10.1016/j.ygeno.2004.11.003
   Bellizzi D, 2009, MOL CELLS, V28, P87, DOI 10.1007/s10059-009-0110-3
   Bhakat KK, 2006, MOL CELL BIOL, V26, P1654, DOI 10.1128/MCB.26.5.1654-1665.2006
   Bharathi SS, 2013, J BIOL CHEM, V288, P33837, DOI 10.1074/jbc.M113.510354
   Bienso RS, 2014, PFLUG ARCH EUR J PHY, V466, P1647, DOI 10.1007/s00424-013-1399-5
   Bigrigg JK, 2009, AM J PHYSIOL-REG I, V297, pR885, DOI 10.1152/ajpregu.90604.2008
   Borengasser SJ, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024068
   Boyle KE, 2013, J CLIN ENDOCR METAB, V98, pE1601, DOI 10.1210/jc.2013-1943
   Cao K, 2014, FREE RADICAL BIO MED, V67, P396, DOI 10.1016/j.freeradbiomed.2013.11.029
   Chen CJ, 2013, BIOCHEM BIOPH RES CO, V430, P798, DOI 10.1016/j.bbrc.2012.11.066
   Chen YH, 2011, EMBO REP, V12, P534, DOI 10.1038/embor.2011.65
   Cheng Y, 2013, CELL DEATH DIS, V4, DOI 10.1038/cddis.2013.254
   Cui J, 2012, NUTRITION, V28, P275, DOI 10.1016/j.nut.2011.10.016
   D'Aquila P, 2012, GENE, V497, P323, DOI 10.1016/j.gene.2012.01.042
   Dali-Youcef N, 2007, ANN MED, V39, P335, DOI 10.1080/07853890701408194
   Dong CH, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027157
   Donmez G, 2010, AGING CELL, V9, P285, DOI 10.1111/j.1474-9726.2010.00548.x
   Du JT, 2011, SCIENCE, V334, P806, DOI 10.1126/science.1207861
   Du ZD, 2012, HEARING RES, V287, P15, DOI 10.1016/j.heares.2012.04.012
   Dugan LL, 2013, J CLIN INVEST, V123, P4888, DOI 10.1172/JCI66218
   Dyck JRB, 2006, CIRCULATION, V114, P1721, DOI 10.1161/CIRCULATIONAHA.106.642009
   Dyck JRB, 2004, CIRC RES, V94, pE78, DOI 10.1161/01.RES.0000129255.19569.8f
   Finley LWS, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023295
   Gertz M, 2010, BBA-PROTEINS PROTEOM, V1804, P1658, DOI 10.1016/j.bbapap.2009.09.011
   Glorioso C, 2011, NEUROBIOL DIS, V41, P279, DOI 10.1016/j.nbd.2010.09.016
   Glozak MA, 2007, ONCOGENE, V26, P5420, DOI 10.1038/sj.onc.1210610
   Guarente L, 2005, CELL, V120, P473, DOI 10.1016/j.cell.2005.01.029
   Guo CC, 2011, CURR OPIN NEUROL, V24, P648, DOI 10.1097/WCO.0b013e32834cd415
   Hafner AV, 2010, AGING-US, V2, P914, DOI 10.18632/aging.100252
   Haigis MC, 2006, CELL, V126, P941, DOI 10.1016/j.cell.2006.06.057
   Haigis MC, 2010, ANNU REV PATHOL-MECH, V5, P253, DOI 10.1146/annurev.pathol.4.110807.092250
   Halim ND, 2010, GLIA, V58, P1168, DOI 10.1002/glia.20996
   Hallows WC, 2006, P NATL ACAD SCI USA, V103, P10230, DOI 10.1073/pnas.0604392103
   Hallows WC, 2011, MOL CELL, V41, P139, DOI 10.1016/j.molcel.2011.01.002
   Hirschey MD, 2011, MOL CELL, V44, P177, DOI 10.1016/j.molcel.2011.07.019
   Hirschey MD, 2010, NATURE, V464, P121, DOI 10.1038/nature08778
   Hoehn KL, 2008, CELL METAB, V7, P421, DOI 10.1016/j.cmet.2008.04.005
   HSU CC, 1995, ACTA NEUROL SCAND, V92, P252
   Huang B, 2013, SCI REP-UK, V3, DOI 10.1038/srep01933
   Jezek P, 2005, INT J BIOCHEM CELL B, V37, P2478, DOI 10.1016/j.biocel.2005.05.013
   Jing EX, 2013, DIABETES, V62, P3404, DOI 10.2337/db12-1650
   Jing EX, 2011, P NATL ACAD SCI USA, V108, P14608, DOI 10.1073/pnas.1111308108
   Kendrick AA, 2011, BIOCHEM J, V433, P505, DOI 10.1042/BJ20100791
   Kim SC, 2006, MOL CELL, V23, P607, DOI 10.1016/j.molcel.2006.06.026
   Klein DK, 2007, AM J PHYSIOL-ENDOC M, V293, pE1242, DOI 10.1152/ajpendo.00382.2007
   Koopman WJH, 2013, EMBO J, V32, P9, DOI 10.1038/emboj.2012.300
   Koyama T, 2011, FREE RADICAL BIO MED, V51, P1258, DOI 10.1016/j.freeradbiomed.2011.05.028
   Lanza IR, 2008, DIABETES, V57, P2933, DOI 10.2337/db08-0349
   Lee HC, 2012, ADV EXP MED BIOL, V942, P311, DOI 10.1007/978-94-007-2869-1_14
   Liang QL, 2013, BIOCHEM J, V454, P249, DOI 10.1042/BJ20130414
   Lieber CS, 2008, BIOCHEM BIOPH RES CO, V373, P246, DOI 10.1016/j.bbrc.2008.06.006
   Lin SJ, 2002, NATURE, V418, P344, DOI 10.1038/nature00829
   Liu B, 2013, CELL PHYSIOL BIOCHEM, V32, P1050, DOI 10.1159/000354505
   Liu CY, 2009, BBA-MOL BASIS DIS, V1792, P783, DOI 10.1016/j.bbadis.2009.05.005
   Lombard DB, 2007, MOL CELL BIOL, V27, P8807, DOI 10.1128/MCB.01636-07
   Lombard David B, 2011, Handb Exp Pharmacol, V206, P163, DOI 10.1007/978-3-642-21631-2_8
   Longo VD, 2006, CELL, V126, P257, DOI 10.1016/j.cell.2006.07.002
   Lu CY, 1999, MUTAT RES-FUND MOL M, V423, P11, DOI 10.1016/S0027-5107(98)00220-6
   Ma YS, 2005, ANN NY ACAD SCI, V1042, P55, DOI 10.1196/annals.1338.006
   Maassen JA, 1997, HORM METAB RES, V29, P50, DOI 10.1055/s-2007-978984
   Mayers RM, 2005, BIOCHEM SOC T, V33, P367, DOI 10.1042/BST0330367
   McBride HM, 2006, CURR BIOL, V16, pR551, DOI 10.1016/j.cub.2006.06.054
   Morán M, 2012, FREE RADICAL BIO MED, V53, P595, DOI 10.1016/j.freeradbiomed.2012.05.009
   Nadal-Casellas A, 2010, CELL PHYSIOL BIOCHEM, V26, P291, DOI 10.1159/000320552
   Nakagawa T, 2009, CELL, V137, P560, DOI 10.1016/j.cell.2009.02.026
   Noeman SA, 2011, DIABETOL METAB SYNDR, V3, DOI 10.1186/1758-5996-3-17
   Osborne B, 2014, BBA-GEN SUBJECTS, V1840, P1295, DOI 10.1016/j.bbagen.2013.08.016
   Ozden O, 2011, AGING-US, V3, P102, DOI 10.18632/aging.100291
   Palacios OM, 2009, AGING-US, V1, P771, DOI 10.18632/aging.100075
   Park J, 2013, MOL CELL, V50, P919, DOI 10.1016/j.molcel.2013.06.001
   Pehleman TL, 2005, J APPL PHYSIOL, V98, P100, DOI 10.1152/japplphysiol.00686.2004
   Peng C, 2011, MOL CELL PROTEOMICS, V10, DOI 10.1074/mcp.M111.012658
   Perez-Martinez P, 2012, MOL NUTR FOOD RES, V56, P67, DOI 10.1002/mnfr.201100531
   Pfister JA, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0004090
   Pham TX, 2012, NUTRIENTS, V4, P1868, DOI 10.3390/nu4121868
   Pillai VB, 2010, CARDIOVASC RES, V88, P250, DOI 10.1093/cvr/cvq250
   Pillai VB, 2010, J BIOL CHEM, V285, P3133, DOI 10.1074/jbc.M109.077271
   Piquereau J, 2012, CARDIOVASC RES, V94, P408, DOI 10.1093/cvr/cvs117
   Pollex RL, 2006, NAT CLIN PRACT CARD, V3, P482, DOI 10.1038/ncpcardio0638
   Qiu XL, 2010, CELL METAB, V12, P662, DOI 10.1016/j.cmet.2010.11.015
   Rardin MJ, 2013, CELL METAB, V18, P920, DOI 10.1016/j.cmet.2013.11.013
   Rhee SG, 2006, SCIENCE, V312, P1882, DOI 10.1126/science.1130481
   Roche HM, 2005, P NUTR SOC, V64, P371, DOI 10.1079/PNS2005445
   Rodenburg RJT, 2011, J INHERIT METAB DIS, V34, P283, DOI 10.1007/s10545-010-9081-y
   Samant SA, 2014, MOL CELL BIOL, V34, P807, DOI 10.1128/MCB.01483-13
   Samuel VT, 2012, CELL, V148, P852, DOI 10.1016/j.cell.2012.02.017
   Schlicker C, 2008, J MOL BIOL, V382, P790, DOI 10.1016/j.jmb.2008.07.048
   Schwer B, 2006, P NATL ACAD SCI USA, V103, P10224, DOI 10.1073/pnas.0603968103
   Shi T, 2005, J BIOL CHEM, V280, P13560, DOI 10.1074/jbc.M414670200
   Shi T, 2010, J DIGEST DIS, V11, P55, DOI 10.1111/j.1751-2980.2009.00416.x
   Shimazu T, 2010, CELL METAB, V12, P654, DOI 10.1016/j.cmet.2010.11.003
   Shulga N, 2010, J CELL SCI, V123, P894, DOI 10.1242/jcs.061846
   Slaby O, 2013, NUTR CANCER, V65, P247, DOI 10.1080/01635581.2013.756530
   Someya S, 2010, CELL, V143, P802, DOI 10.1016/j.cell.2010.10.002
   Someya S, 2009, P NATL ACAD SCI USA, V106, P19432, DOI 10.1073/pnas.0908786106
   Stacpoole PW, 2012, AGING CELL, V11, P371, DOI 10.1111/j.1474-9726.2012.00805.x
   Sundaresan NR, 2008, MOL CELL BIOL, V28, P6384, DOI 10.1128/MCB.00426-08
   Sundaresan NR, 2009, J CLIN INVEST, V119, P2758, DOI 10.1172/JCI39162
   Tao RD, 2010, MOL CELL, V40, P893, DOI 10.1016/j.molcel.2010.12.013
   Ussher JR, 2009, DIABETES, V58, P1766, DOI 10.2337/db09-0011
   Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
   Vassilopoulos A, 2014, ANTIOXID REDOX SIGN, V21, P551, DOI 10.1089/ars.2013.5420
   Wallace DC, 2005, ANNU REV GENET, V39, P359, DOI 10.1146/annurev.genet.39.110304.095751
   Wang CH, 2013, EXP BIOL MED, V238, P450, DOI 10.1177/1535370213493069
   Wang QJ, 2010, SCIENCE, V327, P1004, DOI 10.1126/science.1179687
   Wei YH, 2003, ADV CLIN CHEM, V37, P83, DOI 10.1016/S0065-2423(03)37007-6
   Wolfgang MJ, 2011, FEBS J, V278, P552, DOI 10.1111/j.1742-4658.2010.07978.x
   Wu PF, 1998, BIOCHEM J, V329, P197, DOI 10.1042/bj3290197
   Wu SB, 2014, BBA-GEN SUBJECTS, V1840, P1331, DOI 10.1016/j.bbagen.2013.10.034
   Wu SB, 2012, BBA-MOL BASIS DIS, V1822, P233, DOI 10.1016/j.bbadis.2011.09.014
   Wu YT, 2013, BBA-MOL BASIS DIS, V1832, P216, DOI 10.1016/j.bbadis.2012.10.002
   Xue L, 2012, FEBS LETT, V586, P137, DOI 10.1016/j.febslet.2011.11.031
   Yang XJ, 2007, EMBO REP, V8, P556, DOI 10.1038/sj.embor.7400977
   Yang YJ, 2010, J BIOL CHEM, V285, P7417, DOI 10.1074/jbc.M109.053421
   Yechoor VK, 2004, P NATL ACAD SCI USA, V101, P16525, DOI 10.1073/pnas.0407574101
   Yoshino J, 2011, MOL CELL, V44, P170, DOI 10.1016/j.molcel.2011.10.005
   Yu W, 2012, J BIOL CHEM, V287, P14078, DOI 10.1074/jbc.M112.355206
   Yuzefovych LV, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054059
   Zhang S, 2014, NUTR METAB, V11, DOI 10.1186/1743-7075-11-10
   Zhang ZH, 2011, NAT CHEM BIOL, V7, P58, DOI 10.1038/NCHEMBIO.495
NR 127
TC 40
Z9 46
U1 0
U2 36
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PD SEP
PY 2014
VL 48
IS 9
BP 1070
EP 1084
DI 10.3109/10715762.2014.920956
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA AN3AA
UT WOS:000340456000010
PM 24797412
DA 2025-06-11
ER

PT J
AU Flahault, A
   Paquette, K
   Fernandes, RO
   Delfrate, J
   Cloutier, A
   Henderson, M
   Lavoie, JC
   Mâsse, B
   Nuyt, AM
   Luu, TM
AF Flahault, Adrien
   Paquette, Katryn
   Fernandes, Rafael Oliveira
   Delfrate, Jacques
   Cloutier, Anik
   Henderson, Melanie
   Lavoie, Jean-Claude
   Masse, Benoit
   Nuyt, Anne Monique
   Luu, Thuy Mai
CA HAPI Collaborating Grp
TI Increased Incidence but Lack of Association Between Cardiovascular Risk
   Factors in Adults Born Preterm
SO HYPERTENSION
LA English
DT Article
DE adiposity; diabetes mellitus; inflammation; metabolic syndrome;
   oxidative stress
ID C-REACTIVE PROTEIN; OXIDATIVE STRESS; BLOOD-PRESSURE; YOUNG-ADULTS;
   METABOLIC SYNDROME; BIRTH-WEIGHT; OXYGEN; MARKERS; HEALTH; INFLAMMATION
AB Preterm birth incurs an increased risk of early cardiovascular events and death. In the general population, cardiovascular risk factors cluster in the context of inflammation and oxidative stress. Whether this also occurs in young adults born preterm is unknown. We analyzed 101 healthy young adults (ages 18-29) born preterm (<= 29 weeks of gestation) and 105 full-term controls, predominantly (90%) white. They underwent a comprehensive clinical and biological evaluation, including measurement of blood pressure, lung function (spirometry), glucose metabolism (fasting glucose, glycated hemoglobin, and oral glucose tolerance test), as well as biomarkers of inflammation and oxidative stress. Individuals born preterm were at higher risk than those born full-term of stage >= 1 hypertension (adjusted odds ratio, 2.91 [95% CI, 1.51-5.75]), glucose intolerance (adjusted odds ratio, 2.22 [95% CI, 1.13-4.48]), and airflow limitation (adjusted odds ratio, 3.47 [95% CI, 1.76-7.12]). Hypertension was strongly associated with adiposity and with glucose intolerance in participants born full-term but not in those born preterm. We did not find any group difference in levels of biomarkers of inflammation and oxidative stress. In individuals born preterm, inflammation, and oxidative stress were not related to hypertension or glucose intolerance but were associated with adiposity. In those born preterm, cardiovascular risk factors were not related to each other suggesting different pathophysiological pathways leading to the development of cardiovascular risk following preterm birth. Clinicians should consider screening for these abnormalities irrespectively of other risk factors in this at-risk population.
C1 [Flahault, Adrien; Paquette, Katryn; Fernandes, Rafael Oliveira; Delfrate, Jacques; Cloutier, Anik; Henderson, Melanie; Nuyt, Anne Monique; Luu, Thuy Mai] Univ Montreal, St Justine Univ Hosp & Res Ctr, Dept Pediat, Montreal, PQ, Canada.
   [Lavoie, Jean-Claude] Univ Montreal, St Justine Univ Hosp & Res Ctr, Dept Nutr, Montreal, PQ, Canada.
   [Masse, Benoit] Univ Montreal, St Justine Univ Hosp & Res Ctr, Dept Social & Prevent Med, Montreal, PQ, Canada.
C3 Universite de Montreal; Universite de Montreal; Universite de Montreal
RP Nuyt, AM; Luu, TM (corresponding author), St Justine Univ Hosp & Res Ctr, Dept Pediat, 3175 Chemin Cote St Catherine, Montreal, PQ H3T 1C5, Canada.
EM anne.monique.nuyt@umontreal.ca; thuy.mai.luu@umontreal.ca
RI Lavoie, Jean-claude/K-2701-2016; Luu, Thuy Mai/HKE-8217-2023; Flahault,
   Adrien/KAM-1829-2024; Flahault, Adrien/Q-4576-2017; Oliveira Fernandes,
   Rafael/V-7782-2018
OI Flahault, Adrien/0000-0003-4632-6332; Bertagnolli,
   Mariane/0000-0002-1093-1445; Oliveira Fernandes,
   Rafael/0000-0003-0853-726X
FU Canadian Institutes of Health Research [CIHR 133572]; Canada Foundation
   for Innovation; Fondation CHU Sainte-Justine; Fonds de recherche du
   Quebec -Sante (FRQS); FRQS/Fondation des Etoiles fellowship award
FX This work was supported by the Canadian Institutes of Health Research
   (CIHR 133572 to A.M. Nuyt and T.M. Luu), the Canada Foundation for
   Innovation (to A.M. Nuyt) and the Fondation CHU Sainte-Justine (to A.M.
   Nuyt), a Fonds de recherche du Quebec -Sante (FRQS) salary award to T.M.
   Luu, a FRQS/Fondation des Etoiles fellowship award to A. Flahault.
CR Agustí A, 2017, LANCET RESP MED, V5, P935, DOI 10.1016/S2213-2600(17)30434-4
   American Diabetes Association, 2018, Diabetes Care, V41, pS13, DOI 10.2337/dc18-S002
   [Anonymous], Who.int Waist Circumference and Waist-Hip Ratio: Report of a WHO Expert Consultation
   Bavineni M, 2019, EUR HEART J, V40, P1107, DOI 10.1093/eurheartj/ehz025
   Boivin A, 2012, CAN MED ASSOC J, V184, P1777, DOI 10.1503/cmaj.120143
   Cazzola M, 2010, RESPIRATION, V80, P112, DOI 10.1159/000281880
   Cesari M, 2003, CIRCULATION, V108, P2317, DOI 10.1161/01.CIR.0000097109.90783.FC
   Crump C, 2019, JAMA PEDIATR, V173, P736, DOI 10.1001/jamapediatrics.2019.1327
   Crump C, 2019, BMJ-BRIT MED J, V365, DOI 10.1136/bmj.l1346
   Doyle LW, 2017, NEW ENGL J MED, V377, P329, DOI 10.1056/NEJMoa1700827
   Fitzgerald E, 2018, CURR GENOMICS, V19, P507, DOI 10.2174/1389202919666171229144807
   Gluckman PD, 2004, SCIENCE, V305, P1733, DOI 10.1126/science.1095292
   HADLOCK FP, 1991, RADIOLOGY, V181, P129, DOI 10.1148/radiology.181.1.1887021
   Helenius K, 2017, PEDIATRICS, V140, DOI 10.1542/peds.2017-1264
   Hovi P, 2016, HYPERTENSION, V68, P880, DOI 10.1161/HYPERTENSIONAHA.116.08167
   Howson CP, 2013, REPROD HEALTH, V10, DOI 10.1186/1742-4755-10-S1-S1
   Huang ZQ, 2016, GENET TEST MOL BIOMA, V20, P322, DOI 10.1089/gtmb.2015.0255
   Joss-Moore LA, 2015, BIOCHEM CELL BIOL, V93, P119, DOI 10.1139/bcb-2014-0093
   Kaptoge S, 2010, LANCET, V375, P132, DOI 10.1016/S0140-6736(09)61717-7
   Katch VL, 2011, ESSENTIALS EXERCISE, P426
   Kramer MS, 2001, PEDIATRICS, V108, DOI 10.1542/peds.108.2.e35
   Lewandowski AJ, 2015, HYPERTENSION, V65, P607, DOI 10.1161/HYPERTENSIONAHA.114.04662
   Mestan K, 2012, EARLY HUM DEV, V88, P683, DOI 10.1016/j.earlhumdev.2012.02.002
   Monnier L, 2006, JAMA-J AM MED ASSOC, V295, P1681, DOI 10.1001/jama.295.14.1681
   Morrison KM, 2016, PEDIATRICS, V138, DOI 10.1542/peds.2016-0515
   Nanduri J, 2012, P NATL ACAD SCI USA, V109, P2515, DOI 10.1073/pnas.1120600109
   Nuyt AM, 2017, CLIN PERINATOL, V44, P315, DOI 10.1016/j.clp.2017.01.010
   Ogawa S, 2006, HYPERTENSION, V47, P699, DOI 10.1161/01.HYP.0000203826.15076.4b
   Paquette K, 2018, HYPERTENSION, V72, P918, DOI 10.1161/HYPERTENSIONAHA.118.11397
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Pastore L, 1999, CIRCULATION, V100, P1646, DOI 10.1161/01.CIR.100.15.1646
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Romero R, 2015, AM J OBSTET GYNECOL, V213, DOI 10.1016/j.ajog.2015.07.037
   Singh D, 2019, EUR RESPIR J, V53, DOI [10.1183/13993003.00164-2019, 10.1007/978-981-13-2221-1_9]
   Sipola-Leppänen M, 2015, AM J EPIDEMIOL, V181, P861, DOI 10.1093/aje/kwu443
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Sugamura K, 2011, FREE RADICAL BIO MED, V51, P978, DOI 10.1016/j.freeradbiomed.2011.05.004
   Torres-Cuevas I, 2017, REDOX BIOL, V12, P674, DOI 10.1016/j.redox.2017.03.011
   Trivel D, 2004, CAN J APPL PHYSIOL, V29, P623, DOI 10.1139/h04-040
   Vento M, 2009, PEDIATRICS, V124, pE439, DOI 10.1542/peds.2009-0434
   Viitasalo A, 2014, DIABETOLOGIA, V57, P940, DOI 10.1007/s00125-014-3172-5
   Whelton PK, 2018, J AM COLL CARDIOL, V71, P2275, DOI 10.1016/j.jacc.2018.03.016
   Whelton PK, 2018, HYPERTENSION, V71, P1269, DOI 10.1161/HYP.0000000000000066
   Xie L, 2019, BONE REP, V10, DOI 10.1016/j.bonr.2018.100189
   Yzydorczyk C, 2008, HYPERTENSION, V52, P889, DOI 10.1161/HYPERTENSIONAHA.108.116251
NR 45
TC 43
Z9 44
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD MAR
PY 2020
VL 75
IS 3
BP 796
EP 805
DI 10.1161/HYPERTENSIONAHA.119.14335
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA LH5NP
UT WOS:000528832000029
PM 31983307
OA Bronze
DA 2025-06-11
ER

PT J
AU Altuna, ME
   Mazzetti, MB
   Rago, LF
   de Viale, LCS
   Damasco, MC
AF Altuna, M. E.
   Mazzetti, M. B.
   Rago, L. F.
   San Martin de Viale, L. C.
   Damasco, M. C.
TI Hepatic 11 beta-hydroxysteroid dehydrogenase 1 involvement in
   alterations of glucose metabolism produced by acidotic stress in rat
SO JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE HSD1; Stress; Glycyrrhetinic acid; Glucose; PEPCK
ID LIVER-GLYCOGEN PHOSPHORYLASE; INDOLE-SITE INHIBITORS; OBESE ZUCKER RATS;
   11-BETA-HYDROXYSTEROID DEHYDROGENASE; GLUCOCORTICOID ACTION; TYPE-1;
   MODEL; CORTISOL; ISOFORMS; MUSCLE
AB M.E. ALTUNA, M.B. MAZZETTI, L.F. RAGO, L.C. SAN MARTIN DE VIALE and M.C. DAMASCO. Hepatic 11 beta-hydroxysteroid dehydrogenase I involvement in alterations of glucose metabolism produced by acidotic stress in rat. J Physiol Biochem, 65 (4), 329-338, 2009.
   11 beta-hydroxysteroid dehydrogenase (HSDs) enzymes regulate the activity of glucocorticoids in target organs. HSD1, one of the two existing isoforms, locates mainly in CNS, liver and adipose tissue. HSD1 is involved in the pathogenesis of diseases such as obesity, insulin resistance, arterial hypertension and the Metabolic Syndrome. The stress produced by HCl overload triggers metabolic acidosis and increases liver HSD1 activity associated with increased phosphoenolpyruvate carboxykinase, a regulatory enzyme of gluconeogenesis that is activated by glucocorticoids, with increased glycaemia and glycogen breakdown. The aim of this study was to analyze whether the metabolic modifications triggered by HCl stress are due to increased liver HSD1 activity. Glycyrrhetinic acid, a potent HDS inhibitor, was administered subcutaneously (20 mg/ml) to stressed and unstressed four months old male Sprague Dawley rats to investigate changes in liver HSD1, phosphoenolpyruvate carboxykinase (PECPK) and glycogen phosphorylase activities and plasma glucose levels. It was observed that all these parameters increased in stressed animals, but that treatment with glycyrrhetinic acid significantly reduced their levels. In conclusion, our results demonstrate the involvement of HSD1 in stress induced carbohydrate disturbances and could contribute to the impact of HSD1 inhibitors on carbohydrate metabolism and its relevance in the study of Metabolic Syndrome Disorder and non insulin-dependent diabetes mellitus.
C1 [Altuna, M. E.; Rago, L. F.; Damasco, M. C.] Consejo Nacl Invest Cient & Tecn, Lab Fis Endocrina, RA-1033 Buenos Aires, DF, Argentina.
   [Mazzetti, M. B.; San Martin de Viale, L. C.] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Biol, Lab Disturbios Metab Xenobiot Salud Humana & Medi, Buenos Aires, DF, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   University of Buenos Aires
RP Damasco, MC (corresponding author), Consejo Nacl Invest Cient & Tecn, Lab Fis Endocrina, RA-1033 Buenos Aires, DF, Argentina.
EM dimxsa@qb.fcen.uba.ar
FU CONICET (Consejo Nacional de Investigaciones Cientificas y Tecnicas);
   Universidad de Buenos Aires
FX This work has been supported by grants from the CONICET (Consejo
   Nacional de Investigaciones Cientificas y Tecnicas) and the Universidad
   de Buenos Aires. M.C. Damasco and L.C. San Martin de Via le are
   Scientific Research Career Members of the CONICET.
CR Altuna ME, 2006, CAN J PHYSIOL PHARM, V84, P977, DOI 10.1139/Y06-046
   AYES BN, 1966, METHOD ENZYMOL, V8, P115
   Baker DJ, 2005, DIABETES, V54, P2453, DOI 10.2337/diabetes.54.8.2453
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Cuadri-Tomé C, 2006, J MOL RECOGNIT, V19, P451, DOI 10.1002/jmr.772
   Ercan-Fang N, 2005, AM J PHYSIOL-ENDOC M, V289, pE366, DOI 10.1152/ajpendo.00264.2004
   Ercan-Fang N, 2002, AM J PHYSIOL-ENDOC M, V283, pE29, DOI 10.1152/ajpendo.00425.2001
   Freeman S, 2006, BRIT J PHARMACOL, V149, P775, DOI 10.1038/sj.bjp.0706925
   Hanson RW, 1997, ANNU REV BIOCHEM, V66, P581, DOI 10.1146/annurev.biochem.66.1.581
   Harris HJ, 2001, ENDOCRINOLOGY, V142, P114, DOI 10.1210/en.142.1.114
   Henke BR, 2006, MINI-REV MED CHEM, V6, P845, DOI 10.2174/138955706777934991
   Hermanowski-Vosatka A, 2005, J EXP MED, V202, P517, DOI 10.1084/jem.20050119
   HIROSHI H, 1999, AM J PHYSIOL-ENDOC M, V277, pE624
   Hu GX, 2008, J ANDROL, V29, P345, DOI 10.2164/jandrol.107.004242
   Igarreta P, 1999, LIFE SCI, V64, P2285, DOI 10.1016/S0024-3205(99)00179-4
   Jin JY, 2004, J PHARMACOL EXP THER, V309, P328, DOI 10.1124/jpet.103.061515
   KAGEYAMA Y, 1992, J ENDOCRINOL, V135, P147, DOI 10.1677/joe.0.1350147
   Lelli SM, 2005, TOXICOLOGY, V216, P49, DOI 10.1016/j.tox.2005.07.016
   Li RS, 2004, METABOLISM, V53, P600, DOI 10.1016/j.metabol.2003.11.010
   Livingstone DEW, 2003, J PHARMACOL EXP THER, V305, P167, DOI 10.1124/jpet.102.044842
   Livingstone DEW, 2000, ENDOCRINOLOGY, V141, P560, DOI 10.1210/en.141.2.560
   Mazzetti MB, 2004, ARCH TOXICOL, V78, P25, DOI 10.1007/s00204-003-0470-y
   NEWMAN JD, 1978, BIOCHIM BIOPHYS ACTA, V544, P225, DOI 10.1016/0304-4165(78)90092-2
   Ogg D, 2005, J BIOL CHEM, V280, P3789, DOI 10.1074/jbc.M412463200
   Oppermann UCT, 1997, EUR J BIOCHEM, V249, P355, DOI 10.1111/j.1432-1033.1997.t01-1-00355.x
   PETRESCU I, 1979, ANAL BIOCHEM, V96, P279, DOI 10.1016/0003-2697(79)90582-7
   Seckl JR, 2001, ENDOCRINOLOGY, V142, P1371, DOI 10.1210/en.142.4.1371
   Seckl JR, 1997, FRONT NEUROENDOCRIN, V18, P49, DOI 10.1006/frne.1996.0143
   Shimoyama Y, 2003, J PHARM PHARMACOL, V55, P811, DOI 10.1211/002235703765951429
   Stewart PM, 1999, VITAM HORM, V57, P249
   Stimson R H, 2007, Minerva Endocrinol, V32, P141
   Walker BR, 2006, DIABETIC MED, V23, P1281, DOI 10.1111/j.1464-5491.2006.01998.x
   WHORWOOD CB, 1993, ENDOCRINOLOGY, V132, P2287, DOI 10.1210/en.132.6.2287
   Zallocchi M, 2004, CAN J PHYSIOL PHARM, V82, P422, DOI 10.1139/Y04-035
   Zallocchi ML, 2004, J CELL BIOCHEM, V92, P591, DOI 10.1002/jcb.20078
NR 35
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1138-7548
EI 1877-8755
J9 J PHYSIOL BIOCHEM
JI J. Physiol. Biochem.
PD DEC
PY 2009
VL 65
IS 4
BP 329
EP 337
DI 10.1007/BF03185927
PG 9
WC Biochemistry & Molecular Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Physiology
GA 580IW
UT WOS:000276442600001
PM 20358345
DA 2025-06-11
ER

PT J
AU Sundkvist, GMG
   Hjemdahl, P
   Kahan, T
   Melcher, A
AF Sundkvist, G. M. G.
   Hjemdahl, P.
   Kahan, T.
   Melcher, A.
TI Mechanisms of exercise-induced ST-segment depression in patients without
   typical angina pectoris
SO JOURNAL OF INTERNAL MEDICINE
LA English
DT Article
DE adrenaline; adrenoceptors; electrocardiography; exercise test; tissue
   Doppler imaging
ID CORONARY-ARTERY-DISEASE; REGIONAL DIASTOLIC FUNCTION;
   ISCHEMIC-HEART-DISEASE; TISSUE DOPPLER; STRESS ECHOCARDIOGRAPHY;
   PERFUSION SCINTIGRAPHY; MYOCARDIAL-ISCHEMIA; CHEST PAIN; SYNDROME-X;
   EPINEPHRINE
AB Background. To evaluate if exercise-induced ST-segment depression without typical angina pectoris is related to increases in sympatho-adrenal activity or beta-adrenoceptor sensitivity.
   Patients.Thirteen patients (four men) aged 35-62 years with ST-segment depression during exercise but atypical symptoms and normal myocardial scintigraphy, and 13 matched controls.
   Design and interventions. Patients and controls were compared regarding responses with: (i) exercise testing without treatment, (ii) exercise testing following beta-adrenoceptor blockade by propranolol (0.15 mg kg(-1) i.v.), (iii) incremental adrenaline infusions (0.1, 0.2, 0.4 and 0.8 nmol kg(-1) min(-1)) and (iv) adrenaline infusions during alpha-adrenoceptor blockade by phentolamine (0.5 mg min(-1)).
   Main outcome measures. ST-segment depression and tissue Doppler parameters reflecting contractility.
   Results. Exercise lowered the ST-segment by 2.44 mm without and 0.87 mm with beta-adrenoceptor blockade (P < 0.001 for difference) amongst patients, but not amongst controls. Maximal heart rate was slightly higher amongst patients (P < 0.05), despite similar loads and plasma catecholamine responses to exercise in the two groups; this difference disappeared after beta-adrenoceptor blockade with propranolol. ST-segment depression during adrenaline infusion was greater in patients compared with controls (P < 0.01) despite similar increases in heart rate. alpha-Blockade enhanced the ST-segment depression (P < 0.001) and heart rate (P < 0.001) responses to adrenaline infusion more markedly amongst patients. Tissue Doppler imaging showed similar contractility and diastolic relaxation responses of patients and controls to adrenaline, but early diastolic movements did not increase amongst patients after phentolamine (P < 0.01).
   Conclusions. Exercise-induced ST-segment depression in patients with a low likelihood of ischaemic heart disease is related to increased beta-adrenergic sensitivity regarding chronotropic and electrophysiological, but not inotropic responses.
C1 Danderyd Hosp, Karolinska Inst, Dept Clin Sci, Div Clin Physiol, Stockholm, Sweden.
   Karolinska Univ Hosp Solna, Dept Med, Clin Pharmacol Unit, SE-17176 Stockholm, Sweden.
   Danderyd Hosp, Karolinska Inst, Dept Clin Sci, Div Internal Med, Stockholm, Sweden.
C3 Karolinska Institutet; Danderyds Hospital; Karolinska Institutet;
   Karolinska University Hospital; Danderyds Hospital; Karolinska
   Institutet
RP Melcher, A (corresponding author), Karolinska Univ Hosp Solna, Dept Clin Physiol N2 01, SE-17176 Stockholm, Sweden.
EM anmelc@ki.se
RI Kahan, Thomas/JBJ-7622-2023
OI Kahan, Thomas/0000-0001-9909-4956; Hjemdahl, Paul/0000-0001-5346-275X
CR Beller GA, 2000, CIRCULATION, V101, P1465, DOI 10.1161/01.CIR.101.12.1465
   BERMAN DS, 1995, J AM COLL CARDIOL, V26, P639, DOI 10.1016/0735-1097(95)00218-S
   BORG G, 1970, Scandinavian Journal of Rehabilitation Medicine, V2, P92
   BROWN MJ, 1983, NEW ENGL J MED, V309, P1414, DOI 10.1056/NEJM198312083092303
   CANNON RO, 1992, CIRCULATION, V85, P883, DOI 10.1161/01.CIR.85.3.883
   ERIKSSON B, 1995, AM J CARDIOL, V75, P241, DOI 10.1016/0002-9149(95)80028-Q
   Furberg C, 1968, Acta Med Scand Suppl, V488, P7
   FURBERG C, 1967, ACTA MED SCAND, V181, P21
   García-Fernández MA, 1999, EUR HEART J, V20, P496, DOI 10.1053/euhj.1998.1278
   GIANROSSI R, 1989, CIRCULATION, V80, P87, DOI 10.1161/01.CIR.80.1.87
   Gorcsan J, 1998, AM J CARDIOL, V81, P615, DOI 10.1016/S0002-9149(97)00973-9
   Heusch G, 2000, CIRCULATION, V101, P689, DOI 10.1161/01.CIR.101.6.689
   HJEMDAHL P, 1987, METHOD ENZYMOL, V142, P521
   Kahan T, 1998, J CARDIOVASC PHARM, V32, P753, DOI 10.1097/00005344-199811000-00011
   LARSSON PT, 1992, CLIN SCI, V82, P369, DOI 10.1042/cs0820369
   Mädler CF, 2003, EUR HEART J, V24, P1584, DOI 10.1016/S0195-668X(03)00099-X
   Nagueh SF, 1998, CIRCULATION, V98, P1644, DOI 10.1161/01.CIR.98.16.1644
   OKEEFE JH, 1995, AM J CARDIOL, V75, pD25, DOI 10.1016/S0002-9149(99)80399-3
   Pálinkás A, 2002, EUR HEART J, V23, P1587, DOI 10.1053/euhj.2002.3170
   Pasquet A, 1999, J AM SOC ECHOCARDIOG, V12, P901, DOI 10.1016/S0894-7317(99)70142-2
   Rigo F, 2002, AM J CARDIOL, V89, P1141, DOI 10.1016/S0002-9149(02)02292-0
   SAHN DJ, 1978, CIRCULATION, V58, P1072, DOI 10.1161/01.CIR.58.6.1072
   Shan K, 2000, J AM COLL CARDIOL, V36, P891, DOI 10.1016/S0735-1097(00)00786-5
   SJOSTRAND T, 1967, CLIN PHYSL, P184
   STRATTON JR, 1985, J APPL PHYSIOL, V58, P1199, DOI 10.1152/jappl.1985.58.4.1199
   SURAWICZ B, 1989, COMPREHENSIVE ELECTR, P511
   Tavel ME, 2001, CHEST, V119, P907, DOI 10.1378/chest.119.3.907
   Vinereanu D, 2002, POSTGRAD MED J, V78, P40, DOI 10.1136/pmj.78.915.40
   von Bibra H, 2000, J AM COLL CARDIOL, V36, P444, DOI 10.1016/S0735-1097(00)00735-X
NR 29
TC 4
Z9 4
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0954-6820
EI 1365-2796
J9 J INTERN MED
JI J. Intern. Med.
PD FEB
PY 2007
VL 261
IS 2
BP 148
EP 158
DI 10.1111/j.1365-2796.2006.01751.x
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 125XH
UT WOS:000243476300007
PM 17241180
OA Bronze
DA 2025-06-11
ER

PT J
AU Hein, M
   Lanquart, JP
   Loas, G
   Hubain, P
   Linkowski, P
AF Hein, Matthieu
   Lanquart, Jean-Pol
   Loas, Gwenole
   Hubain, Philippe
   Linkowski, Paul
TI Prevalence and Risk Factors of Type 2 Diabetes in Major Depression: A
   Study on 703 Individuals Referred for Sleep Examinations
SO PSYCHOSOMATICS
LA English
DT Article
DE Major depression; Type 2 diabetes; Prevalence; Risk factors
ID C-REACTIVE PROTEIN; EXCESSIVE DAYTIME SLEEPINESS; INFLAMMATORY MARKERS;
   MEDICATION ADHERENCE; ALCOHOL-CONSUMPTION; GENERAL-POPULATION; METABOLIC
   SYNDROME; SEX-DIFFERENCES; PRIMARY-CARE; MELLITUS
AB Background: Several studies have investigated the prevalence and risk factors of depression in individuals with type 2 diabetes. However, few studies have investigated the prevalence and risk factors for type 2 diabetes in major depression. Objective: The aim of this study was to examine the prevalence and risk factors of type 2 diabetes in a large sample of individuals with major depression. Methods: Data from 703 individuals with major depression recruited from the research database of the sleep laboratory of the Erasme Hospital were analysed. Only individuals with a diagnosis of type 2 diabetes according to the diagnostic criteria of the American Diabetes Association were included in the diabetes group. Logistic regression analyses were conducted to examine clinical and demographic risk factors of type 2 diabetes in major depression. Results: The prevalence of type 2 diabetes in major depression is 21.2%. Multivariate logistic regression analysis revealed that male sex, high blood pressure, hypertriglyceridemia, BMI >= 30 kg/m(2), age >= 50 years, sleep duration <6.5 hours, C-reactive protein >= 4.5 mgIL, Beck Depression Inventory > 12, and apnea-hypopnea index >= 51h were significant risk factors of type 2 diabetes in major depression. Conclusion: Type 2 diabetes is a common condition in major depression. In this subpopulation, most of the risk factors for type 2 diabetes are reversible, which justifies better prevention and management of this disorder to avoid its negative consequences.
C1 [Hein, Matthieu; Lanquart, Jean-Pol; Loas, Gwenole; Hubain, Philippe; Linkowski, Paul] ULB, Erasme Hosp, Dept Psychiat, B-8081070 Brussels, Belgium.
   [Hein, Matthieu; Lanquart, Jean-Pol; Loas, Gwenole; Hubain, Philippe; Linkowski, Paul] ULB, Erasme Hosp, Sleep Lab, B-8081070 Brussels, Belgium.
C3 Universite Libre de Bruxelles; Universite Libre de Bruxelles
RP Hein, M (corresponding author), ULB, Erasme Hosp, Dept Psychiat, B-8081070 Brussels, Belgium.; Hein, M (corresponding author), ULB, Erasme Hosp, Sleep Lab, B-8081070 Brussels, Belgium.
EM matthieu.hein@erasme.ulb.ac.be
RI Hein, Matthieu/IVV-2577-2023
OI Hein, Matthieu/0000-0003-4243-1653
CR Ali S, 2006, DIABETIC MED, V23, P1165, DOI 10.1111/j.1464-5491.2006.01943.x
   Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
   American Psychiatric Association, 2000, spectrum disorders using the current DSM-IV-TR diagnostic, V4th, DOI 10.1176/dsm10.1176/appi.books.9780890420249.dsm-iv-tr
   [Anonymous], 2015, DIABETES CARE, V38, pS8, DOI 10.2337/dc15-S005
   [Anonymous], 2004, DIABETES CARE, V27, pS11, DOI [10.2337/diacare.27.2007.S11, DOI 10.2337/DIACARE.27.2007.S11]
   Appelhans BM, 2012, J ACAD NUTR DIET, V112, P693, DOI 10.1016/j.jand.2012.02.006
   Baliunas DO, 2009, DIABETES CARE, V32, P2123, DOI 10.2337/dc09-0227
   Barnard K, 2013, DIABETES CARE, V36, P3337, DOI 10.2337/dc13-0560
   Barrett-Connor E, 1999, J CLIN ENDOCR METAB, V84, P573, DOI 10.1210/jc.84.2.573
   Beck AT, 1996, J PERS ASSESS, V67, P588, DOI 10.1207/s15327752jpa6703_13
   Berry RB, 2012, J CLIN SLEEP MED, V8, P597, DOI 10.5664/jcsm.2172
   Bhattacharjee S, 2013, DIABETES-METAB RES, V29, P273, DOI 10.1002/dmrr.2393
   Bhattacharyya N, 2015, LARYNGOSCOPE, V125, P2413, DOI 10.1002/lary.25346
   Boden G, 2001, ENDOCRIN METAB CLIN, V30, P801, DOI 10.1016/S0889-8529(05)70216-4
   Bogner HR, 2007, DIABETES CARE, V30, P3005, DOI 10.2337/dc07-0974
   Bogner HR, 2012, ANN FAM MED, V10, P15, DOI 10.1370/afm.1344
   Bringer J, 2009, DIABETES METAB, V35, P25, DOI 10.1016/j.diabet.2008.06.004
   Caporale JE, 2013, GLOBALIZATION HEALTH, V9, DOI 10.1186/1744-8603-9-54
   Chan O, 2003, Minerva Endocrinol, V28, P87
   Chehade JM, 2013, DRUGS, V73, P327, DOI 10.1007/s40265-013-0023-5
   Chellappa SL, 2006, REV BRAS PSIQUIATR, V28, P126, DOI 10.1590/S1516-44462006000200010
   Clark NG, 2007, DIABETES CARE, V30, P2868, DOI 10.2337/dc07-0816
   Coll JL, 2015, OBESITY FACTS, V8, P220, DOI 10.1159/000435826
   Corona G, 2011, INT J ANDROL, V34, P528, DOI 10.1111/j.1365-2605.2010.01117.x
   de Groot M, 2001, PSYCHOSOM MED, V63, P619, DOI 10.1097/00006842-200107000-00015
   DiMatteo MR, 2000, ARCH INTERN MED, V160, P2101, DOI 10.1001/archinte.160.14.2101
   Ding D, 2015, DIABETES RES CLIN PR, V108, P306, DOI 10.1016/j.diabres.2015.02.002
   Ding EL, 2006, JAMA-J AM MED ASSOC, V295, P1288, DOI 10.1001/jama.295.11.1288
   Doi Y, 2005, DIABETES CARE, V28, P2497, DOI 10.2337/diacare.28.10.2497
   Egede LE, 2004, DIABETES CARE, V27, P421, DOI 10.2337/diacare.27.2.421
   Egede LE, 2010, DIABETES RES CLIN PR, V87, P302, DOI 10.1016/j.diabres.2010.01.024
   Elmasry A, 2000, J INTERN MED, V248, P13, DOI 10.1046/j.1365-2796.2000.00683.x
   Fleetham John, 2006, Can Respir J, V13, P387
   Foran E, 2015, IRISH J MED SCI, V184, P319, DOI 10.1007/s11845-014-1110-7
   Fritschi C, 2010, J PSYCHOSOM RES, V69, P33, DOI 10.1016/j.jpsychores.2010.01.021
   Gangwisch JE, 2009, OBES REV, V10, P37, DOI 10.1111/j.1467-789X.2009.00663.x
   Grenard JL, 2011, J GEN INTERN MED, V26, P1175, DOI 10.1007/s11606-011-1704-y
   Hayley AC, 2015, METABOLISM, V64, P244, DOI 10.1016/j.metabol.2014.09.011
   Hein M, 2017, PSYCHIAT RES, V258, P387, DOI 10.1016/j.psychres.2017.08.061
   Hein M, 2017, BMC PSYCHIATRY, V17, DOI 10.1186/s12888-017-1438-4
   Holliday EG, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0082305
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Huang YF, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-260
   Hubain PP, 1998, BIOL PSYCHIAT, V43, P220, DOI 10.1016/S0006-3223(97)80434-9
   Iber C., 2007, AASM MANUAL SCORING, V1
   Imazu M, 2002, CURR HYPERTENS REP, V4, P477, DOI 10.1007/s11906-002-0029-y
   Jeenger J, 2017, ASIAN J PSYCHIATR, V27, P71, DOI 10.1016/j.ajp.2017.02.016
   JOHNS MW, 1991, SLEEP, V14, P540, DOI 10.1093/sleep/14.6.540
   Joseph J, 2010, SCAND J PUBLIC HEALT, V38, P768, DOI 10.1177/1403494810380299
   Judice PB, 2015, J NUTR HEALTH AGING, V19, P798, DOI 10.1007/s12603-015-0501-4
   Kan C, 2013, DIABETES CARE, V36, P480, DOI 10.2337/dc12-1442
   Knol MJ, 2006, DIABETOLOGIA, V49, P837, DOI 10.1007/s00125-006-0159-x
   Kushida CA, 2005, SLEEP, V28, P499, DOI 10.1093/sleep/28.4.499
   Leproult R, 2010, ENDOCR DEV, V17, P11, DOI 10.1159/000262524
   Lindberg E, 2007, RESP MED, V101, P1283, DOI 10.1016/j.rmed.2006.10.015
   Lombardero A, 2014, ADDICT BEHAV, V39, P538, DOI 10.1016/j.addbeh.2013.10.030
   Lontchi-Yimagou E, 2013, CURR DIABETES REP, V13, P435, DOI 10.1007/s11892-013-0375-y
   Cerón EM, 2015, ARCH BRONCONEUMOL, V51, P128, DOI 10.1016/j.arbres.2014.06.017
   Matsuzaka H, 2013, INT J PSYCHIAT MED, V46, P203, DOI 10.2190/PM.46.2.g
   Meisinger C, 2005, DIABETOLOGIA, V48, P235, DOI 10.1007/s00125-004-1634-x
   Meisinger C, 2008, J HYPERTENS, V26, P1809, DOI 10.1097/HJH.0b013e328307c3e9
   Meng L, 2012, J HYPERTENS, V30, P842, DOI 10.1097/HJH.0b013e32835080b7
   Morin CM., 1993, Insomnia: psychological assessment and management
   Naqvi HA, 2014, CURR PSYCHIAT REP, V16, DOI 10.1007/s11920-014-0519-z
   Nouwen A, 2010, DIABETOLOGIA, V53, P2480, DOI 10.1007/s00125-010-1874-x
   Pan A, 2015, LANCET DIABETES ENDO, V3, P958, DOI 10.1016/S2213-8587(15)00316-2
   Park M, 2013, GEN HOSP PSYCHIAT, V35, P217, DOI 10.1016/j.genhosppsych.2013.01.006
   Penninx BWJH, 2007, AM J GERIAT PSYCHIAT, V15, P522, DOI 10.1097/JGP.0b013e318033ed80
   PRICHARD BNC, 1992, J CARDIOVASC PHARM, V20, pS77, DOI 10.1097/00005344-199200111-00013
   Regenold WT, 2002, J AFFECT DISORDERS, V70, P19, DOI 10.1016/S0165-0327(01)00456-6
   Rosella LC, 2015, DIABETES CARE, V38, P1299, DOI 10.2337/dc14-2474
   Roshanaei-Moghaddam B, 2009, GEN HOSP PSYCHIAT, V31, P306, DOI 10.1016/j.genhosppsych.2009.04.002
   Rotella F, 2013, DIABETES RES CLIN PR, V99, P98, DOI 10.1016/j.diabres.2012.11.022
   Salvi V, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0182088
   Schunk M, 2012, DIABETIC MED, V29, P646, DOI 10.1111/j.1464-5491.2011.03465.x
   Sebbani M, 2014, ENCEPHALE, V40, P9, DOI 10.1016/j.encep.2013.03.006
   Seike N, 2008, ASIA PAC J CLIN NUTR, V17, P545
   Shaw JE, 2010, DIABETES RES CLIN PR, V87, P4, DOI 10.1016/j.diabres.2009.10.007
   Stroe AF, 2010, SLEEP MED, V11, P890, DOI 10.1016/j.sleep.2010.04.010
   SURRIDGE DHC, 1984, BRIT J PSYCHIAT, V145, P269, DOI 10.1192/bjp.145.3.269
   Thorand B, 2007, DIABETES CARE, V30, P854, DOI 10.2337/dc06-1693
   Thorp AA, 2011, AM J PREV MED, V41, P207, DOI 10.1016/j.amepre.2011.05.004
   Unger G, 2014, ENDOCRINOL NUTR, V61, P533, DOI 10.1016/j.endonu.2014.06.009
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vancampfort D, 2015, DEPRESS ANXIETY, V32, P763, DOI 10.1002/da.22387
   Waki K, 2005, DIABETIC MED, V22, P323, DOI 10.1111/j.1464-5491.2004.01403.x
   Wang B., 2016, The Lancet Diabetes Endocrinology, V4, pS36, DOI 10.1016/S2213-8587(16)30391-6
   WANG X, 2013, BRIT J RADIOL, V86
   Wang X, 2013, DIABETES CARE, V36, P166, DOI 10.2337/dc12-0702
   Wong E, 2013, LANCET DIABETES ENDO, V1, P106, DOI 10.1016/S2213-8587(13)70046-9
   Xiong XL, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/1958981
   Yu M, 2015, CAN J DIABETES, V39, P266, DOI 10.1016/j.jcjd.2014.11.006
   Zhang MZ, 2015, SCI REP-UK, V5, DOI 10.1038/srep18495
   Zhu B, 2014, ASIA-PAC J PUBLIC HE, V26, P226, DOI 10.1177/1010539514531041
NR 94
TC 15
Z9 18
U1 0
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0033-3182
EI 1545-7206
J9 PSYCHOSOMATICS
JI Psychosomatics
PD MAR-APR
PY 2018
VL 59
IS 2
BP 144
EP 157
DI 10.1016/j.psym.2017.11.003
PG 14
WC Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA FZ3FT
UT WOS:000427472800005
PM 29246639
DA 2025-06-11
ER

PT S
AU Oxenkrug, GF
   Summergrad, P
AF Oxenkrug, Gregory F.
   Summergrad, Paul
BE Andrews, RJ
   Slikker, W
   Trembly, B
   Patterson, TA
TI Ramelteon attenuates age-associated hypertension and weight gain in
   spontaneously hypertensive rats
SO NEUROPROTECTIVE AGENTS
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 9th International Conference on Neuroprotective Agents
CY SEP 07-11, 2008
CL Marine Biol Lab, Woods Hole, MA
HO Marine Biol Lab
DE Ramelteon; melatonin; hypertension; weight gain; aging; age;
   spontaneously hypertensive rats; metabolic syndrome; age-associated
   neuroendocrine disorders
ID COLD-IMMOBILIZATION STRESS; MT1/MT2 RECEPTOR AGONIST; BLOOD-PRESSURE;
   VASCULAR REACTIVITY; N-ACETYLSEROTONIN; BODY-WEIGHT; MELATONIN
   RECEPTORS; REPLACEMENT THERAPY; ARTERY; WOMEN
AB The neuroendocrine theory of aging suggests the common mechanisms of developmental (prereproductive) and aging (postreproductive) processes and identified a cluster of conditions (hypertension, obesity, dyslipidemia, type 2 diabetes, menopause, late onset depression, vascular cognitive impairment, impairment of immune defense, and some forms of cancer) as age-associated neuroendocrine disorders (AAND). Obesity, dyslipidemia, hypertension, and type 2 diabetes were later described as metabolic syndrome (MetS). Because melatonin attenuated development of MetS is age-dependent, that is, in young and old, but not in middle-aged rats, we studied the effect of the selective melatonin agonist, Ramelteon, on the two core symptoms of MetS/AAND: hypertension and body weight gain in spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto male rats (WKY). SHR rats developed hypertension at the time of maximal weight gain that coincided with the onset of reproductive activity (8-10 weeks old). Chronic (but not acute) administration of Ramelteon (in drinking water, 8 mg/kg/day, from 4 to 12 weeks of age) attenuated age-associated increase of systolic blood pressure (tail-cuff method) by 45%, and age-associated body weight gain by 30%. Acute and chronic Ramelteon did not affect blood pressure and body weight in normotensive WKY rats. Ramelteon-induced attenuation of age-associated hypertension and weight gain suggests that Ramelteon might attenuate the other symptoms of MetS/AAND and might be useful in the treatment of MetS/AAND during puberty, menopause, and old age.
C1 [Oxenkrug, Gregory F.] Tufts Univ, Sch Med, Dept Psychiat, Psychiat & Inflammat Program, Boston, MA 02111 USA.
   Tufts Med Ctr, Boston, MA USA.
C3 Tufts University; Tufts Medical Center
RP Oxenkrug, GF (corresponding author), Tufts Univ, Sch Med, Dept Psychiat, Psychiat & Inflammat Program, Boston, MA 02111 USA.
EM goxenkrug@tuftsmedicalcenter.org
RI Summergrad, Paul/AAI-1698-2021
OI Summergrad, Paul/0000-0001-9991-6761; Oxenkrug,
   Gregory/0000-0002-7193-9117
FU Takeda Pharmaceuticals, Inc.
FX This study was supported by a grant from Takeda Pharmaceuticals, Inc.
   The authors are thankful for the excellent technical support provided by
   Ms. S. Borochin.
CR Arangino S, 1999, AM J CARDIOL, V83, P1417, DOI 10.1016/S0002-9149(99)00112-5
   Brandacher G, 2007, CURR DRUG METAB, V8, P289, DOI 10.2174/138920007780362590
   Brandacher G, 2006, OBES SURG, V16, P541, DOI 10.1381/096089206776945066
   Cagnacci A, 2005, AM J HYPERTENS, V18, P1614, DOI 10.1016/j.amjhyper.2005.05.008
   Cagnacci A, 2001, CLIN ENDOCRINOL, V54, P261, DOI 10.1046/j.1365-2265.2001.01204.x
   Cagnacci A, 1997, J PINEAL RES, V22, P16, DOI 10.1111/j.1600-079X.1997.tb00297.x
   CUNNANE SC, 1980, CAN J PHYSIOL PHARM, V58, P287, DOI 10.1139/y80-049
   Dilman V., 1979, Serotonin in Health and Diseases, V5, P111
   DILMAN VM, 1971, LANCET, V1, P1211
   Dilman VM, 1994, Development, Aging and Disease: A New Rationale for an Intervention Strategy
   DING CN, ACTA PHARM SIN, V22, P997
   Dubocovich ML, 2003, FRONT BIOSCI-LANDMRK, V8, pD1093, DOI 10.2741/1089
   Enzminger H, 2001, J PINEAL RES, V31, P256, DOI 10.1034/j.1600-079X.2001.310310.x
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   France CP, 2006, BEHAV NEUROSCI, V120, P535, DOI 10.1037/0735-7044.120.3.535
   Geary GG, 1998, BRIT J PHARMACOL, V123, P1533, DOI 10.1038/sj.bjp.0701761
   Grossman E, 2006, AM J MED, V119, P898, DOI 10.1016/j.amjmed.2006.02.002
   Hardeland R, 2008, ARZNEIMITTELFORSCH, V58, P1, DOI 10.1055/s-0031-1296459
   He Wei, 1998, Yaoxue Xuebao, V33, P727
   Henderson DC, 2008, J CLIN PSYCHIAT, V69, P32, DOI 10.4088/JCP.0208e04
   Johnson MW, 2006, ARCH GEN PSYCHIAT, V63, P1149, DOI 10.1001/archpsyc.63.10.1149
   Jonas M, 2003, BLOOD PRESSURE, V12, P19, DOI 10.1080/08037050310000418
   KARPPANEN H, 1974, THESIS HELSINKI
   Kato K, 2005, NEUROPHARMACOLOGY, V48, P301, DOI 10.1016/j.neuropharm.2004.09.007
   KAWASHIMA K, 1984, CLIN EXP HYPERTENS A, V6, P1517, DOI 10.3109/10641968409044066
   KAWASHIMA K, 1987, CLIN EXP HYPERTENS A, V9, P1121, DOI 10.3109/10641968709160037
   Kim CY, 2002, EXP ANIM TOKYO, V51, P69, DOI 10.1538/expanim.51.69
   Kitajima T, 2001, PSYCHIAT CLIN NEUROS, V55, P299, DOI 10.1046/j.1440-1819.2001.00866.x
   Laflamme AK, 1998, AM J HYPERTENS, V11, P219, DOI 10.1016/S0895-7061(97)00401-9
   LeGouic S, 1996, INT J OBESITY, V20, P661
   Leibowitz A, 2008, AM J HYPERTENS, V21, P348, DOI 10.1038/ajh.2007.60
   Lusardi, 1997, Blood Press Monit, V2, P99
   Masana MI, 2002, J PHARMACOL EXP THER, V302, P1295, DOI 10.1124/jpet.302.3.1295
   Miyamoto M, 2006, NEUROSCI LETT, V402, P201, DOI 10.1016/j.neulet.2006.02.049
   Mustonen AM, 2001, ENDOCRINE, V16, P43, DOI 10.1385/ENDO:16:1:43
   Nishida S, 2002, J PINEAL RES, V32, P26, DOI 10.1034/j.1600-079x.2002.10797.x
   Nishiyama K, 2001, Am Heart J, V141, pE9, DOI 10.1067/mhj.2001.114368
   Oxenkrug GF, 2003, CNS SPECTRUMS, V8, P139, DOI 10.1017/S109285290001837X
   OXENKRUG GF, 1986, J NEURAL TRANSM, V66, P271, DOI 10.1007/BF01260919
   Oxenkrug GF, 1997, VOP MED KHIM, V43, P522
   Oxenkrug GF, 1998, J NEURAL TRANSM-SUPP, P333
   Oxenkrug GF, 2000, STRESS MEDICINE, V16, P239, DOI 10.1002/1099-1700(200007)16:4<239::AID-SMI858>3.0.CO;2-F
   OXENKRUG GF, 1999, NEUROLOGY, V792, P213
   OXENKRUG GF, 1992, BIOL PSYCHIAT, V31, pS37
   Oxenkrug GF, 2007, ANN NY ACAD SCI, V1122, P35, DOI 10.1196/annals.1403.003
   Pacifico L, 2006, EUR J ENDOCRINOL, V154, P691, DOI 10.1530/eje.1.02138
   Perianayagam MC, 2005, ANN NY ACAD SCI, V1053, P386, DOI 10.1196/annals.1344.033
   Prunet-Marcassus B, 2003, ENDOCRINOLOGY, V144, P5347, DOI 10.1210/en.2003-0693
   Puchalski SS, 2003, ENDOCRINE, V21, P163, DOI 10.1385/ENDO:21:2:163
   Raskind MA, 2007, NEUROPSYCHOPHARMACOL, V32, P284, DOI 10.1038/sj.npp.1301093
   Rasmussen DD, 2001, J PINEAL RES, V31, P89, DOI 10.1034/j.1600-079X.2001.310113.x
   Sanchez-Mateos S, 2007, MATURITAS, V58, P91, DOI 10.1016/j.maturitas.2007.06.006
   Scheer FAJL, 2005, AM J HYPERTENS, V18, P1619, DOI 10.1016/j.amjhyper.2005.07.013
   Scheer FAJL, 2004, HYPERTENSION, V43, P192, DOI 10.1161/01.HYP.0000113293.15186.3b
   SCHORK NJ, 1994, AM J PHYSIOL, V266, pR702, DOI 10.1152/ajpregu.1994.266.3.R702
   VISWANATHAN M, 1992, NEUROENDOCRINOLOGY, V56, P864, DOI 10.1159/000126318
   Walsh HA, 1997, J PINEAL RES, V23, P20, DOI 10.1111/j.1600-079X.1997.tb00330.x
   Yaprak M, 2003, INT J CARDIOL, V89, P103, DOI 10.1016/S0167-5273(02)00461-8
   YOUNG JB, 1978, METABOLISM, V27, P1711, DOI 10.1016/0026-0495(78)90256-1
   ZANOBONI A., 1967, LIFE SCI, V6, P2327, DOI 10.1016/0024-3205(67)90043-4
NR 60
TC 27
Z9 27
U1 0
U2 8
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA
SN 0077-8923
BN 978-1-57331-777-1
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2010
VL 1199
BP 114
EP 120
DI 10.1111/j.1749-6632.2009.05355.x
PG 7
WC Multidisciplinary Sciences; Neurosciences
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics; Neurosciences & Neurology
GA BRJ59
UT WOS:000282838900013
PM 20633116
DA 2025-06-11
ER

PT J
AU Kim, S
   Hwang, AR
   Kim, SH
   Lim, JH
   Woo, CH
AF Kim, Suji
   Hwang, Ae-Rang
   Kim, Sun-Hee
   Lim, Jae Hyang
   Woo, Chang-Hoon
TI Pentraxin 3 deficiency ameliorates streptozotocin-induced pancreatic
   toxicity via regulating ER stress and 13-cell apoptosis
SO MOLECULES AND CELLS
LA English
DT Article
DE i3-cell; Diabetes mellitus; Endoplasmic reticulum stress; Pentraxin 3
ID PTX3; INFLAMMATION
AB The long pentraxin 3 (PTX3), a marker of inflammation, has been associated with cardiovascular disease, obesity, and metabolic syndrome. Recently, elevated serum PTX3 levels have been linked to type 2 diabetes in obese patients with nonalcoholic fatty liver disease. Diabetes mellitus is a metabolic syndrome characterized by hyperglycemia resulting from insufficient insulin secretion or action. However, the precise role of PTX3 in hyperglycemia remains unclear. This study aimed to investigate the physiological roles of PTX3 in vivo. The deformation of pancreatic islets was mitigated in PTX3deficient mice treated with streptozotocin (STZ) compared to control C57BL/6J mice. In addition, PTX3 deficiency prevented STZ-induced unfolded protein responses and pancreatic 13-cell death. Immunoblotting data revealed significant inhibition of inositol-requiring protein1 alpha and C/EBP homologous protein (CHOP) protein expression in PTX3 KO mice administered tunicamycin which is a chemical endoplasmic reticulum stress inducer. Similarly, tunicamycin-induced Grp78, Grp94, ATF6, and CHOP mRNA levels were reduced in PTX3 KO mice. Moreover, recombinant PTX3-induced CHOP expression and 13-cell apoptosis in primary mouse islets. These findings suggest that PTX3 plays a critical role in STZinduced deformation of pancreatic islets via regulating endoplasmic reticulum stress and 13-cell apoptosis. (c) 2024 The Authors. Published by Elsevier Inc. on behalf of Korean Society for Molecular and Cellular Biology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
C1 [Kim, Suji; Hwang, Ae-Rang; Kim, Sun-Hee; Woo, Chang-Hoon] Yeungnam Univ, Coll Med, Dept Pharmacol, 170 Hyeonchung Ro, Daegu 42415, South Korea.
   [Kim, Suji] Korea Natl Inst Hlth, Dept Chron Dis Convergence Res, Div Cardiovasc Dis Res, 197 Osongsaengmyeng2 Ro, Cheongju 28159, Chungcheongbuk, South Korea.
   [Lim, Jae Hyang] Ewha Womans Univ, Dept Microbiol, Coll Med, 25 Magokdong ro 2 gil, Seoul 07804, South Korea.
   [Woo, Chang-Hoon] Yeungnam Univ, Coll Med, Senotherapy Based Metab Dis Control Res Ctr, 170 Hyunchung Ro, Daegu 42415, South Korea.
C3 Yeungnam University; Korea Disease Control & Prevention Agency (KDCA);
   Korea National Institute of Health (KNIH); Ewha Womans University;
   Yeungnam University
RP Woo, CH (corresponding author), Yeungnam Univ, Coll Med, Dept Pharmacol, 170 Hyeonchung Ro, Daegu 42415, South Korea.; Lim, JH (corresponding author), Ewha Womans Univ, Dept Microbiol, Coll Med, 25 Magokdong ro 2 gil, Seoul 07804, South Korea.; Woo, CH (corresponding author), Yeungnam Univ, Coll Med, Senotherapy Based Metab Dis Control Res Ctr, 170 Hyunchung Ro, Daegu 42415, South Korea.
EM jlim19@ewha.ac.kr; changhoon_woo@y.ac.kr
FU National Research Foundation of Korea - Ministry of Science, ICT, and
   Future Planning [2022R1A5A2018865, 2021R1A2C1010851, RS-2022-00164723]
FX The present work was partly supported by the Medical Research Center
   Program (2022R1A5A2018865) and Research Program (2021R1A2C1010851,
   RS-2022-00164723) through the National Research Foundation of Korea
   funded by the Ministry of Science, ICT, and Future Planning.
CR Ahn C, 2015, MOL CELL ENDOCRINOL, V412, P302, DOI 10.1016/j.mce.2015.05.017
   Banday Mujeeb Z, 2020, Avicenna J Med, V10, P174, DOI 10.4103/ajm.ajm_53_20
   Bonacina F, 2019, CARDIOVASC RES, V115, P1861, DOI 10.1093/cvr/cvz068
   Carrizzo A, 2019, IMMUN AGEING, V16, DOI 10.1186/s12979-019-0144-0
   Chen JL, 2012, KIDNEY INT, V82, P1195, DOI 10.1038/ki.2012.268
   Chen XY, 2023, SIGNAL TRANSDUCT TAR, V8, DOI 10.1038/s41392-023-01570-w
   Daigo K, 2014, IMMUNOL LETT, V161, P38, DOI 10.1016/j.imlet.2014.04.012
   Deban L, 2011, CELL TISSUE RES, V343, P237, DOI 10.1007/s00441-010-1018-0
   Doni A, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.00712
   Eisenbarth G S, 1988, J Diabet Complications, V2, P54, DOI 10.1016/0891-6632(88)90002-5
   Fu Z, 2013, CURR DIABETES REV, V9, P25, DOI 10.2174/157339913804143225
   Guo H, 2020, INT J OBESITY, V44, P525, DOI 10.1038/s41366-019-0402-4
   Karamfilova V, 2022, METAB SYNDR RELAT D, V20, P132, DOI 10.1089/met.2021.0086
   Katakami N, 2013, DIABETES RES CLIN PR, V99, P185, DOI 10.1016/j.diabres.2012.11.020
   Lenzen S, 2008, DIABETOLOGIA, V51, P216, DOI 10.1007/s00125-007-0886-7
   Moalli F, 2011, J BIOMED BIOTECHNOL, P1, DOI 10.1155/2011/830421
   Nam DH, 2015, J MOL CELL CARDIOL, V85, P168, DOI 10.1016/j.yjmcc.2015.05.016
   Norata GD, 2010, TRENDS CARDIOVAS MED, V20, P35, DOI 10.1016/j.tcm.2010.03.005
   Norata GD, 2009, CIRCULATION, V120, P699, DOI 10.1161/CIRCULATIONAHA.108.806547
   Oyadomari S, 2004, CELL DEATH DIFFER, V11, P381, DOI 10.1038/sj.cdd.4401373
   Qiu C, 2023, BIOCHEM BIOPH RES CO, V677, P20, DOI 10.1016/j.bbrc.2023.08.001
   Sahin Gulcan Semra, 2021, Mol Metab, V54, P101365, DOI 10.1016/j.molmet.2021.101365
   Salio M, 2008, CIRCULATION, V117, P1055, DOI 10.1161/CIRCULATIONAHA.107.749234
   Sano R, 2013, BBA-MOL CELL RES, V1833, P3460, DOI 10.1016/j.bbamcr.2013.06.028
   Trojak A, 2019, POL ARCH INTERN MED, V129, P499, DOI 10.20452/pamw.14913
   Yong J, 2021, NAT REV ENDOCRINOL, V17, P455, DOI 10.1038/s41574-021-00510-4
   Zhang H, 2022, BIOMED PHARMACOTHER, V156, DOI 10.1016/j.biopha.2022.113783
   Zlibut A, 2019, ADV CLIN CHEM, V91, P163, DOI 10.1016/bs.acc.2019.03.005
NR 28
TC 1
Z9 1
U1 1
U2 1
PU KOREAN SOC MOLECULAR & CELLULAR  BIOLOGY
PI SEOUL
PA 635-4, YUCKSAM-DONG, GANGNAM-GU, SEOUL 135-703, SOUTH KOREA
SN 1016-8478
EI 0219-1032
J9 MOL CELLS
JI Mol. Cells
PD JAN
PY 2025
VL 48
IS 1
AR 100168
DI 10.1016/j.mocell.2024.100168
EA DEC 2024
PG 8
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA U5W3L
UT WOS:001412489800001
PM 39657836
OA gold
DA 2025-06-11
ER

PT J
AU Wu, FM
   Bu, SY
   Wang, HM
AF Wu, Fengming
   Bu, Siyuan
   Wang, Hongmei
TI Role of TRP Channels in Metabolism-Related Diseases
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE TRP channel; diabetes; hypertension; atherosclerosis; nonalcoholic fatty
   liver disease; oxidative stress
ID RECEPTOR POTENTIAL CHANNELS; FATTY LIVER-DISEASE; SMOOTH-MUSCLE-CELLS;
   ENDOTHELIUM-DEPENDENT HYPERPOLARIZATION; PANCREATIC BETA-CELLS;
   INSULIN-SECRETION; OXIDATIVE STRESS; VANILLOID TYPE-1; CATION CHANNELS;
   ACTIVATION
AB Metabolic syndrome (MetS), with its high prevalence and significant impact on cardiovascular disease, poses a substantial threat to human health. The early identification of pathological abnormalities related to MetS and prevention of the risk of associated diseases is of paramount importance. Transient Receptor Potential (TRP) channels, a type of nonselective cation channel, are expressed in a variety of tissues and have been implicated in the onset and progression of numerous metabolism-related diseases. This study aims to review and discuss the expression and function of TRP channels in metabolism-related tissues and blood vessels, and to elucidate the interactions and mechanisms between TRP channels and metabolism-related diseases. A comprehensive literature search was conducted using keywords such as TRP channels, metabolic syndrome, pancreas, liver, oxidative stress, diabetes, hypertension, and atherosclerosis across various academic databases including PubMed, Google Scholar, Elsevier, Web of Science, and CNKI. Our review of the current research suggests that TRP channels may be involved in the development of metabolism-related diseases by regulating insulin secretion and release, lipid metabolism, vascular functional activity, oxidative stress, and inflammatory response. TRP channels, as nonselective cation channels, play pivotal roles in sensing various intra- and extracellular stimuli and regulating ion homeostasis by osmosis. They present potential new targets for the diagnosis or treatment of metabolism-related diseases.
C1 [Wu, Fengming; Bu, Siyuan; Wang, Hongmei] Southeast Univ, Sch Med, Nanjing 210009, Peoples R China.
C3 Southeast University - China
RP Wang, HM (corresponding author), Southeast Univ, Sch Med, Nanjing 210009, Peoples R China.
EM 213190486@seu.edu.cn; siyuanbu@126.com; 101012573@seu.edu.cn
RI Wang, Hongmei/HGT-7374-2022
OI Wang, Hongmei/0000-0002-6975-9467
FU Zhishan Scholars Programs of Southeast University
FX We would like to extend our deepest gratitude to the editors and the
   anonymous referees for the effort they have invested in reviewing and
   critiquing our study.
CR Alawi KM, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-02439-z
   Ali ES, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10081243
   Alkhatib O, 2019, J NEUROSCI, V39, P7840, DOI 10.1523/JNEUROSCI.0882-19.2019
   Altman MK, 2021, DEVELOPMENT, V148, DOI 10.1242/dev.194928
   Araújo MC, 2023, PHARMACEUTICALS-BASE, V16, DOI 10.3390/ph16081100
   Araújo MC, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11081292
   Becker Alexander, 2020, Cell Physiol Biochem, V54, P1115, DOI 10.33594/000000304
   Becker SK, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22115897
   Bestall SM, 2018, J CELL SCI, V131, DOI 10.1242/jcs.215939
   Bevan S, 2014, HANDB EXP PHARMACOL, V222, P207, DOI 10.1007/978-3-642-54215-2_9
   Bilecik T, 2019, EUR REV MED PHARMACO, V23, P3088, DOI 10.26355/eurrev_201904_17592
   Buelow Ben, 2008, J Biol Chem, V283, P24571, DOI 10.1074/jbc.M802673200
   Cao DS, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038005
   Chen XJ, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9091983
   Chen XY, 2022, INT J MOL MED, V50, DOI 10.3892/ijmm.2022.5169
   Cheng XY, 2022, EUR J PHARMACOL, V931, DOI 10.1016/j.ejphar.2022.175180
   Ching LC, 2012, MOL MED, V18, P805, DOI 10.2119/molmed.2011.00461
   Ching LC, 2011, CARDIOVASC RES, V91, P492, DOI 10.1093/cvr/cvr104
   Choi SI, 2014, INT J MOL SCI, V15, P16430, DOI 10.3390/ijms150916430
   Chubanov V, 2024, NAT REV NEPHROL, V20, P175, DOI 10.1038/s41581-023-00777-y
   Ciaglia T, 2023, FRONT ONCOL, V12, DOI 10.3389/fonc.2022.1065935
   Cobbina E, 2017, DRUG METAB REV, V49, P197, DOI 10.1080/03602532.2017.1293683
   Cole BA, 2023, CELLS-BASEL, V12, DOI 10.3390/cells12182215
   Colsoul B, 2011, REV PHYSIOL BIOCH P, V161, P87, DOI 10.1007/112_2011_2
   COSENS DJ, 1969, NATURE, V224, P285, DOI 10.1038/224285a0
   Cui YT, 2019, HYPERTENSION, V74, P1021, DOI 10.1161/HYPERTENSIONAHA.119.13358
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   Delcroix V, 2018, CANCERS, V10, DOI 10.3390/cancers10110439
   Dembla S, 2017, ELIFE, V6, DOI 10.7554/eLife.26280
   Derbenev AV, 2016, SEMIN IMMUNOPATHOL, V38, P397, DOI 10.1007/s00281-015-0529-x
   Di A, 2010, CURR OPIN PHARMACOL, V10, P127, DOI 10.1016/j.coph.2009.11.010
   Diver MM, 2019, SCIENCE, V365, P1434, DOI 10.1126/science.aax6672
   Drews A, 2014, BRIT J PHARMACOL, V171, P1019, DOI 10.1111/bph.12521
   Drews G, 2010, ADV EXP MED BIOL, V654, P115, DOI 10.1007/978-90-481-3271-3_7
   Dröge W, 2002, PHYSIOL REV, V82, P47, DOI 10.1152/physrev.00018.2001
   Earley S, 2015, PHYSIOL REV, V95, P645, DOI 10.1152/physrev.00026.2014
   Echtermeyer F, 2019, FASEB J, V33, P10257, DOI 10.1096/fj.201802233R
   Elzamzamy OM, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9020388
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Félétou M, 2016, J CARDIOVASC PHARM, V67, P373, DOI 10.1097/FJC.0000000000000346
   Fluck EC, 2022, CELL REP, V39, DOI 10.1016/j.celrep.2022.110737
   Fonfria E, 2006, J RECEPT SIG TRANSD, V26, P159, DOI 10.1080/10799890600637506
   Forman HJ, 2021, NAT REV DRUG DISCOV, V20, P689, DOI 10.1038/s41573-021-00233-1
   Gao P, 2020, HYPERTENSION, V75, P150, DOI 10.1161/HYPERTENSIONAHA.119.13778
   Gao W, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-017-02657-z
   Gautier M, 2014, BRIT J PHARMACOL, V171, P2582, DOI 10.1111/bph.12561
   Gees M, 2012, COMPR PHYSIOL, V2, P563, DOI 10.1002/cphy.c110026
   Gommers LMM, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0217925
   Goswami R, 2017, FREE RADICAL BIO MED, V110, P142, DOI 10.1016/j.freeradbiomed.2017.06.004
   Goto K, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.728979
   Griendling KK, 2021, CIRC RES, V128, P993, DOI 10.1161/CIRCRESAHA.121.318063
   Harada K, 2017, J BIOL CHEM, V292, P10855, DOI 10.1074/jbc.M117.788653
   Hellenthal KEM, 2021, BIOMOLECULES, V11, DOI 10.3390/biom11101401
   Hilton JK, 2019, ACCOUNTS CHEM RES, V52, P1643, DOI 10.1021/acs.accounts.9b00075
   Hong KS, 2020, KOREAN J PHYSIOL PHA, V24, P287, DOI 10.4196/kjpp.2020.24.4.287
   Hong ZW, 2016, FRONT CELL NEUROSCI, V10, DOI 10.3389/fncel.2016.00232
   Hu ZC, 2018, BIOMED PHARMACOTHER, V105, P697, DOI 10.1016/j.biopha.2018.06.029
   Huang YH, 2020, CELL CALCIUM, V85, DOI 10.1016/j.ceca.2019.102111
   Hughes TET, 2019, ELIFE, V8, DOI 10.7554/eLife.49572
   Hughes TET, 2018, NAT STRUCT MOL BIOL, V25, P53, DOI 10.1038/s41594-017-0009-1
   Inoue H, 2014, FREE RADICAL BIO MED, V72, P257, DOI 10.1016/j.freeradbiomed.2014.04.015
   Islam MS, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9030685
   Islam MS, 2020, ADV EXP MED BIOL, V1131, P943, DOI 10.1007/978-3-030-12457-1_37
   Islam MS, 2011, ADV EXP MED BIOL, V704, P811, DOI 10.1007/978-94-007-0265-3_42
   Iwata Y, 2020, LAB INVEST, V100, P207, DOI 10.1038/s41374-019-0349-z
   Jesus RLC, 2023, J HYPERTENS, V41, P1351, DOI 10.1097/HJH.0000000000003487
   Jimenez I, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9122604
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Katsiki N, 2016, METABOLISM, V65, P1109, DOI 10.1016/j.metabol.2016.05.003
   Kelava L, 2022, CRIT REV FOOD SCI, V62, P7025, DOI 10.1080/10408398.2021.1910138
   Khajavi N, 2018, CELL SIGNAL, V51, P13, DOI 10.1016/j.cellsig.2018.07.006
   Kheradpezhouh E, 2018, BIOCHEM BIOPH RES CO, V503, P1891, DOI 10.1016/j.bbrc.2018.07.132
   Kim J, 2019, PFLUG ARCH EUR J PHY, V471, P1045, DOI 10.1007/s00424-019-02289-w
   Kozai D, 2014, ANTIOXID REDOX SIGN, V21, P971, DOI 10.1089/ars.2013.5616
   Krishnan V, 2019, BBA-MOL BASIS DIS, V1865, P445, DOI 10.1016/j.bbadis.2018.11.004
   Kumar M, 2023, BIOMED PHARMACOTHER, V163, DOI 10.1016/j.biopha.2023.114861
   Kurashina T, 2015, SCI REP-UK, V5, DOI 10.1038/srep14041
   Lacerda JT, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23137014
   Lam D, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0193312
   Larsson MH, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0138373
   Lee E, 2015, FASEB J, V29, P3182, DOI 10.1096/fj.14-268300
   Lee MY, 2008, ANTIOXID REDOX SIGN, V10, P1045, DOI 10.1089/ars.2007.1986
   Lei XH, 2022, CELL DEATH DIS, V13, DOI 10.1038/s41419-022-05475-4
   Li BH, 2014, CELL DEATH DIS, V5, DOI 10.1038/cddis.2014.146
   Li DL, 2023, TISSUE CELL, V82, DOI 10.1016/j.tice.2023.102038
   Li FF, 2017, CELL DEATH DIFFER, V24, P1999, DOI 10.1038/cdd.2017.118
   Li HY, 2017, ADV EXP MED BIOL, V976, P1, DOI 10.1007/978-94-024-1088-4_1
   Li L, 2012, PFLUG ARCH EUR J PHY, V463, P727, DOI 10.1007/s00424-012-1078-y
   Li Q, 2013, PFLUG ARCH EUR J PHY, V465, P1303, DOI 10.1007/s00424-013-1274-4
   Liang JL, 2023, ONCOL LETT, V25, DOI 10.3892/ol.2023.13678
   Lin JH, 2016, FEBS LETT, V590, P520, DOI 10.1002/1873-3468.12088
   Liu DY, 2014, SCI CHINA LIFE SCI, V57, P818, DOI 10.1007/s11427-014-4713-3
   Liu YS, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms241512509
   Liu YS, 2022, FRONT MOL BIOSCI, V9, DOI 10.3389/fmolb.2022.895814
   Ma LQ, 2011, CARDIOVASC RES, V92, P504, DOI 10.1093/cvr/cvr245
   Ma WZ, 2019, J BIOL CHEM, V294, P2935, DOI 10.1074/jbc.RA118.005504
   Malenczyk K, 2017, EMBO J, V36, P2107, DOI 10.15252/embj.201695347
   Malko P, 2020, REDOX BIOL, V37, DOI 10.1016/j.redox.2020.101755
   Malkoa P, 2021, ADV PROTEIN CHEM STR, V125, P51, DOI 10.1016/bs.apcsb.2020.12.001
   Manda-Handzlik A, 2015, ADV EXP MED BIOL, V857, P51, DOI 10.1007/5584_2015_117
   Mao AQ, 2022, BRIT J PHARMACOL, V179, P2297, DOI 10.1111/bph.15755
   Marabita F, 2017, PANCREAS, V46, P97, DOI 10.1097/MPA.0000000000000685
   Marche P, 2017, SCI REP-UK, V7, DOI 10.1038/srep44322
   Martín-Bórnez M, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21176125
   Matos GM, 2022, J DIABETES RES, V2022, DOI 10.1155/2022/3975147
   Miller BA, 2016, J PHYSIOL-LONDON, V594, P4181, DOI 10.1113/JP270934
   Naylor J, 2010, CIRC RES, V106, P1507, DOI 10.1161/CIRCRESAHA.110.219329
   Negri S, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9061341
   Negri S, 2020, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.01618
   Neuberger A, 2023, NAT COMMUN, V14, DOI 10.1038/s41467-023-38352-5
   Nilius B, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-3-218
   Nishida Motohiro, 2020, J Lipid Atheroscler, V9, P124
   Nishiyama K, 2021, CURR MOL PHARMACOL, V14, P123, DOI 10.2174/1874467213666200407090121
   Numaga-Tomita T, 2019, FASEB J, V33, P9785, DOI 10.1096/fj.201802811R
   Ríos MO, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0212158
   Otto M, 2020, J CLIN INVEST, V130, P4999, DOI 10.1172/JCI136621
   Ottolini M, 2020, CIRCULATION, V141, P1318, DOI 10.1161/CIRCULATIONAHA.119.043385
   Pendharkar SA, 2017, ANN TRANSL MED, V5, DOI 10.21037/atm.2017.08.27
   Peng J.B., 2018, Calcium Entry Channels in Non-Excitable Cells, P241, DOI [DOI 10.1201/9781315152592-13, 10.1201/9781315152592-13]
   Philippaert K, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms14733
   Piciu F, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12071327
   Pumroy RA, 2022, NAT COMMUN, V13, DOI 10.1038/s41467-022-30083-3
   Qian Ke, 2022, Dis Markers, V2022, P3100943, DOI 10.1155/2022/3100943
   Rached G, 2023, ADV SCI, V10, DOI 10.1002/advs.202204846
   Ramsey IS, 2006, ANNU REV PHYSIOL, V68, P619, DOI 10.1146/annurev.physiol.68.040204.100431
   Rode B, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-37299-8
   Rorsman P, 2013, ANNU REV PHYSIOL, V75, P155, DOI 10.1146/annurev-physiol-030212-183754
   Rubaiy HN, 2019, BRIT J PHARMACOL, V176, P832, DOI 10.1111/bph.14578
   Rychkov GY, 2011, ADV EXP MED BIOL, V704, P667, DOI 10.1007/978-94-007-0265-3_35
   Sabourin J, 2016, J MOL ENDOCRINOL, V57, pF35, DOI 10.1530/JME-16-0106
   Sabourin J, 2015, J BIOL CHEM, V290, P30530, DOI 10.1074/jbc.M115.682583
   Sakaguchi R, 2020, FREE RADICAL BIO MED, V146, P36, DOI 10.1016/j.freeradbiomed.2019.10.415
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Samson SL, 2014, ENDOCRIN METAB CLIN, V43, P1, DOI 10.1016/j.ecl.2013.09.009
   Sanders OD, 2021, J OBES METAB SYNDR, V30, P4
   Santoni G, 2020, LAB INVEST, V100, P186, DOI 10.1038/s41374-019-0333-7
   Santoni Giorgio, 2019, Med Sci (Basel), V7, DOI 10.3390/medsci7120108
   Sawatani T, 2019, AM J PHYSIOL-CELL PH, V316, pC434, DOI 10.1152/ajpcell.00210.2017
   Schaar A, 2019, J CELL SCI, V132, DOI 10.1242/jcs.231878
   Seki T, 2017, HYPERTENSION, V69, P143, DOI 10.1161/HYPERTENSIONAHA.116.07110
   Senadheera S, 2012, CARDIOVASC RES, V95, P439, DOI 10.1093/cvr/cvs208
   Seth RK, 2017, FREE RADICAL BIO MED, V102, P260, DOI 10.1016/j.freeradbiomed.2016.11.047
   Shanks J, 2019, HYPERTENSION, V74, P910, DOI 10.1161/HYPERTENSIONAHA.119.13285
   Shin MK, 2019, CIRC RES, V125, P989, DOI 10.1161/CIRCRESAHA.119.315338
   Singh R, 2020, TOXICOL APPL PHARM, V402, DOI 10.1016/j.taap.2020.115124
   Siveen KS, 2020, DIS MARKERS, V2020, DOI 10.1155/2020/8892312
   Skrzypski M, 2015, BBA-MOL CELL RES, V1853, P3202, DOI 10.1016/j.bbamcr.2015.09.012
   Skrzypski M, 2013, FEBS LETT, V587, P3281, DOI 10.1016/j.febslet.2013.08.025
   Smani T, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01731
   Smedlund K, 2010, CIRC RES, V106, P1479, DOI 10.1161/CIRCRESAHA.109.213314
   Song X, 2019, ACTA BIOMATER, V100, P52, DOI 10.1016/j.actbio.2019.10.013
   Sonkusare SK, 2012, SCIENCE, V336, P597, DOI 10.1126/science.1216283
   Su WY, 2023, MOLECULES, V28, DOI 10.3390/molecules28020774
   Sullivan MN, 2013, AM J PHYSIOL-CELL PH, V305, pC999, DOI 10.1152/ajpcell.00273.2013
   Sun J, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-69
   Tano JY, 2014, CARDIOVASC RES, V101, P138, DOI 10.1093/cvr/cvt231
   Thakore P, 2019, COMPR PHYSIOL, V9, P1249, DOI 10.1002/cphy.c180034
   Tian C, 2020, MOL CELL BIOCHEM, V473, P179, DOI 10.1007/s11010-020-03818-3
   Tian Y, 2018, SCI CHINA LIFE SCI, V61, P1120, DOI 10.1007/s11427-018-9365-7
   Togashi K, 2006, EMBO J, V25, P1804, DOI 10.1038/sj.emboj.7601083
   Tran TDN, 2014, BIOCHEM J, V463, P123, DOI 10.1042/BJ20140065
   Tune JD, 2017, TRANSL RES, V183, P57, DOI 10.1016/j.trsl.2017.01.001
   Turlova E, 2021, TRANSL STROKE RES, V12, P164, DOI 10.1007/s12975-020-00810-3
   Uchida K, 2017, J PHYSIOL SCI, V67, P549, DOI 10.1007/s12576-017-0552-x
   Uchida K, 2014, CELL CALCIUM, V56, P332, DOI 10.1016/j.ceca.2014.07.001
   Uchida K, 2011, ENDOCR J, V58, P1021, DOI 10.1507/endocrj.EJ11-0130
   van Megen WH, 2022, J AM SOC NEPHROL, V33, P547, DOI 10.1681/ASN.2021030392
   Venkatachalam K, 2007, ANNU REV BIOCHEM, V76, P387, DOI 10.1146/annurev.biochem.75.103004.142819
   Vennekens R, 2018, ACTA PHYSIOL, V222, DOI 10.1111/apha.12949
   Villalobos C, 2019, CELL CALCIUM, V81, P59, DOI 10.1016/j.ceca.2019.06.003
   Wang HB, 2020, PHARMACOL THERAPEUT, V209, DOI 10.1016/j.pharmthera.2020.107497
   Wang LF, 2020, CURR OPIN IMMUNOL, V62, P131, DOI 10.1016/j.coi.2020.01.005
   Wang Q, 2020, ATHEROSCLEROSIS, V301, P44, DOI 10.1016/j.atherosclerosis.2020.04.004
   Wang QY, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/6482363
   Wang YB, 2023, CHEMMEDCHEM, V18, DOI 10.1002/cmdc.202200562
   Wang YP, 2017, ATHEROSCLEROSIS, V260, P13, DOI 10.1016/j.atherosclerosis.2017.03.016
   Wei J, 2013, ACTA PHYSIOL, V207, P299, DOI 10.1111/apha.12005
   Wie J, 2015, CHANNELS, V9, P186, DOI 10.1080/19336950.2015.1058454
   Wolfrum C, 2018, AM J PHYSIOL-ENDOC M, V315, pE825, DOI 10.1152/ajpendo.00170.2017
   Wortley MA, 2017, HANDB EXP PHARMACOL, V237, P213, DOI 10.1007/164_2016_63
   Wu RY, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/4706410
   Xie J, 2011, SCI REP-UK, V1, DOI 10.1038/srep00146
   Xie YK, 2022, SCI TRANSL MED, V14, DOI 10.1126/scitranslmed.abh2557
   Xiong SQ, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.117.005495
   Xu TC, 2022, MOL NEUROBIOL, V59, P703, DOI 10.1007/s12035-021-02609-1
   Xue CL, 2022, STEM CELL RES THER, V13, DOI 10.1186/s13287-022-03017-5
   Yamamoto S, 2016, EUR J PHARMACOL, V793, P109, DOI 10.1016/j.ejphar.2016.11.007
   Yang SY, 2016, BIOCHEM J, V473, P1791, DOI 10.1042/BCJ20160137
   Yang XJ, 2022, NEUROSCIENCE, V494, P51, DOI 10.1016/j.neuroscience.2022.02.003
   Ye L, 2012, CELL, V151, P96, DOI 10.1016/j.cell.2012.08.034
   Yin Y, 2022, SCIENCE, V378, P154, DOI 10.1126/science.add1268
   Zhang L, 2013, MOL NUTR FOOD RES, V57, P1080, DOI 10.1002/mnfr.201200716
   Zhang L, 2013, J AGR FOOD CHEM, V61, P4287, DOI 10.1021/jf304471t
   Zhang L, 2013, FOOD FUNCT, V4, P738, DOI 10.1039/c3fo30321g
   Zhang SQ, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.750355
   Zhang T, 2022, INT IMMUNOPHARMACOL, V104, DOI 10.1016/j.intimp.2021.108443
   Zhang XL, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms12109
   Zhang XX, 2014, HANDB EXP PHARMACOL, V222, P189, DOI 10.1007/978-3-642-54215-2_8
   Zhang YT, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11091423
   Zhang Z, 2012, CIRC RES, V111, P1137, DOI 10.1161/CIRCRESAHA.112.273755
   Zhao C, 2023, NEURON, V111, P81, DOI 10.1016/j.neuron.2022.10.002
   Zhao JF, 2016, INT J BIOL SCI, V12, P812, DOI 10.7150/ijbs.15229
   Zheng F, 2019, CIRC RES, V125, P1003, DOI 10.1161/CIRCRESAHA.119.316040
   Zhong WT, 2023, NAT COMMUN, V14, DOI 10.1038/s41467-023-36154-3
   Zhou Y, 2021, BIOCHEM BIOPH RES CO, V545, P157, DOI 10.1016/j.bbrc.2021.01.072
   Zhu ZM, 2016, EXP PHYSIOL, V101, P1338, DOI 10.1113/EP085568
   Zou ZG, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20081877
NR 207
TC 5
Z9 5
U1 3
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2024
VL 25
IS 2
AR 692
DI 10.3390/ijms25020692
PG 30
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GG5D0
UT WOS:001151517100001
PM 38255767
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sun, JR
   Guo, F
   Ran, JJ
   Wu, HS
   Li, Y
   Wang, MX
   Wang, XQ
AF Sun, Jiaru
   Guo, Fang
   Ran, Jinjun
   Wu, Haisheng
   Li, Yang
   Wang, Mingxu
   Wang, Xiaoqin
TI Bibliometric and Visual Analysis of Global Research on Taurine,
   Creatine, Carnosine, and Anserine with Metabolic Syndrome: From 1992 to
   2022
SO NUTRIENTS
LA English
DT Review
DE taurine; creatine; carnosine; anserine; metabolic syndrome; bibliometric
   analysis
ID ISCHEMIC-HEART-DISEASE; UNPROCESSED RED MEAT; INSULIN-RESISTANCE;
   BODY-COMPOSITION; DOUBLE-BLIND; ANTIOXIDANT ACTIVITY;
   GROWTH-PERFORMANCE; OXIDATIVE STRESS; DIETARY TAURINE; LIPID PROFILE
AB Red meat and animal-sourced protein are often disparaged as risk factors for developing metabolic syndrome, while emerging research has shown the beneficial effects of dietary taurine, creatine, carnosine, and anserine which are all exclusively abundant in red meat. Thus, it is imperative to highlight the available evidence to help promote red meat as part of a well-balanced diet to optimize human health. In this study, a bibliometric analysis was conducted to investigate the current research status of dietary taurine, creatine, carnosine, and anserine with metabolic syndrome, identify research hotspots, and delineate developmental trends by utilizing the visualization software CiteSpace. A total of 1094 publications were retrieved via the Web of Science Core Collection from 1992 to 2022. There exists a gradual increase in the number of publications on this topic, but there is still much room for research papers to rise. The United States has participated in the most studies, followed by China and Japan. The University of Sao Paulo was the research institute contributing the most; Kyung Ja Chang and Sanya Roysommuti have been identified as the most prolific authors. The analysis of keywords reveals that obesity, lipid profiles, blood pressure, and glucose metabolism, as well as ergogenic aid and growth promoter have been the research hotspots. Inflammation and diabetic nephropathy will likely be frontiers of future research related to dietary taurine, creatine, carnosine, and anserine. Overall, this paper may provide insights for researchers to further delve into this field and enlist the greater community to re-evaluate the health effects of red meat.
C1 [Sun, Jiaru; Wang, Xiaoqin] Xi An Jiao Tong Univ, Dept Nursing, Hlth Sci Ctr, 76 Yanta West Rd, Xian 710061, Peoples R China.
   [Guo, Fang; Wu, Haisheng; Li, Yang] Univ Hong Kong, Sch Publ Hlth, Pok Fu Lam, 7 Sassoon Rd, Hong Kong, Peoples R China.
   [Ran, Jinjun] Shanghai Jiao Tong Univ, Sch Publ Hlth, Sch Med, Shanghai 200092, Peoples R China.
   [Wang, Mingxu] Xi An Jiao Tong Univ, Sch Publ Hlth, Hlth Sci Ctr, 76 Yanta West Rd, Xian 710061, Peoples R China.
C3 Xi'an Jiaotong University; University of Hong Kong; Shanghai Jiao Tong
   University; Xi'an Jiaotong University
RP Wang, XQ (corresponding author), Xi An Jiao Tong Univ, Dept Nursing, Hlth Sci Ctr, 76 Yanta West Rd, Xian 710061, Peoples R China.; Guo, F (corresponding author), Univ Hong Kong, Sch Publ Hlth, Pok Fu Lam, 7 Sassoon Rd, Hong Kong, Peoples R China.; Wang, MX (corresponding author), Xi An Jiao Tong Univ, Sch Publ Hlth, Hlth Sci Ctr, 76 Yanta West Rd, Xian 710061, Peoples R China.
EM r17691212164@163.com; guof0818@hku.hk; jinjunr@sjtu.edu.cn;
   haisheng@connect.hku.hk; yangli-01@connect.hku.hk;
   wangmx601@mail.xjtu.edu.cn; wangxiaoqin@mail.xjtu.edu.cn
RI Wu, Haisheng/GMX-3181-2022
OI Ran, Jinjun/0000-0002-2684-6341
FU Shaanxi Province Science and Technology Department [2023-YBSF-027]
FX This research was supported by Shaanxi Province Science and Technology
   Department (No. 2023-YBSF-027).
CR Albrecht T, 2017, SCI REP-UK, V7, DOI 10.1038/srep44492
   Aldini G, 2021, FREE RADICAL RES, V55, P321, DOI 10.1080/10715762.2020.1856830
   Aldini G, 2011, J CELL MOL MED, V15, P1339, DOI 10.1111/j.1582-4934.2010.01101.x
   [Anonymous], 2015, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
   [Anonymous], 2017, Contin. Updat. Proj. Expert Rep, P120, DOI [10.1007/s12082-007-0105-4, DOI 10.1007/S12082-007-0105-4]
   Baye E, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-17577-7
   BELLENTANI S, 1987, J LIPID RES, V28, P1021
   Bkaily G, 2020, CAN J PHYSIOL PHARM, V98, P67, DOI 10.1139/cjpp-2019-0313
   Boldyrev AA, 2013, PHYSIOL REV, V93, P1803, DOI 10.1152/physrev.00039.2012
   Bonfleur ML, 2015, LIFE SCI, V135, P15, DOI 10.1016/j.lfs.2015.05.019
   Borck PC, 2018, AMINO ACIDS, V50, P765, DOI 10.1007/s00726-018-2553-3
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Camargo RL, 2015, AMINO ACIDS, V47, P2419, DOI 10.1007/s00726-015-2035-9
   Camargo RL, 2013, ADV EXP MED BIOL, V776, P93, DOI 10.1007/978-1-4614-6093-0_10
   Candow DG, 2015, APPL PHYSIOL NUTR ME, V40, P689, DOI 10.1139/apnm-2014-0498
   Carneiro EA, 2009, J NUTR BIOCHEM, V20, P503, DOI 10.1016/j.jnutbio.2008.05.008
   Chen CM, 2004, P NATL ACAD SCI USA, V101, P5303, DOI 10.1073/pnas.0307513100
   de Courten B, 2016, OBESITY, V24, P1027, DOI 10.1002/oby.21434
   de Sousa MM, 2022, CURR DIABETES REV, V18, DOI 10.2174/1573399817666210712151737
   Donthu N, 2021, J BUS RES, V133, P285, DOI 10.1016/j.jbusres.2021.04.070
   Eliot KA, 2008, J NUTR HEALTH AGING, V12, P208, DOI 10.1007/BF02982622
   Engin A, 2017, ADV EXP MED BIOL, V960, P1, DOI 10.1007/978-3-319-48382-5_1
   Everaert I, 2021, AMINO ACIDS, V53, P1269, DOI 10.1007/s00726-021-03033-4
   Figueroa ALC, 2016, SCI REP-UK, V6, DOI 10.1038/srep36801
   Gualano B, 2014, EXP GERONTOL, V53, P7, DOI 10.1016/j.exger.2014.02.003
   Guan L, 2020, EUR J PHARMACOL, V885, DOI 10.1016/j.ejphar.2020.173533
   Haber CA, 2003, AM J PHYSIOL-ENDOC M, V285, pE744, DOI 10.1152/ajpendo.00355.2002
   Han HL, 2020, POULTRY SCI, V99, P5707, DOI 10.1016/j.psj.2020.07.020
   Han XB, 2012, AMINO ACIDS, V43, P2249, DOI 10.1007/s00726-012-1314-y
   Hansen SH, 2001, DIABETES-METAB RES, V17, P330, DOI 10.1002/dmrr.229
   Harada N, 2004, OBES RES, V12, P1077, DOI 10.1038/oby.2004.135
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Hoseini SM, 2018, AQUACULT NUTR, V24, P324, DOI 10.1111/anu.12563
   Hou YQ, 2019, AMINO ACIDS, V51, P1153, DOI 10.1007/s00726-019-02751-0
   Hultman K, 2007, J PHYSIOL-LONDON, V579, P823, DOI 10.1113/jphysiol.2006.124610
   Nguyen HP, 2015, AQUAC RES, V46, P1101, DOI 10.1111/are.12267
   Ibrahim MA, 2020, HELIYON, V6, DOI 10.1016/j.heliyon.2020.e03209
   Ito T, 2015, J PHARMACOL SCI, V129, P59, DOI 10.1016/j.jphs.2015.08.007
   Ito T, 2014, AMINO ACIDS, V46, P111, DOI 10.1007/s00726-013-1507-z
   Ito T, 2012, AMINO ACIDS, V42, P1529, DOI 10.1007/s00726-011-0883-5
   Jo Hee Geun, 2019, J Exerc Nutrition Biochem, V23, P6, DOI 10.20463/jenb.2019.0025
   Karkabounas S, 2018, J MED FOOD, V21, P1197, DOI 10.1089/jmf.2018.0007
   Key TJ, 2019, CIRCULATION, V139, P2835, DOI 10.1161/CIRCULATIONAHA.118.038813
   Kim KS, 2019, AMINO ACIDS, V51, P245, DOI 10.1007/s00726-018-2659-7
   Kim KS, 2012, EXP MOL MED, V44, P665, DOI 10.3858/emm.2012.44.11.075
   Knuppel A, 2020, INT J EPIDEMIOL, V49, P1540, DOI 10.1093/ije/dyaa142
   Kreider RB, 1998, MED SCI SPORT EXER, V30, P73, DOI 10.1097/00005768-199801000-00011
   Kreider RB, 2017, J INT SOC SPORT NUTR, V14, DOI 10.1186/s12970-017-0173-z
   Kubomura D, 2010, NUTR NEUROSCI, V13, P183, DOI 10.1179/147683010X12611460764363
   KULANTHAIVEL P, 1991, BIOCHEM J, V277, P53, DOI 10.1042/bj2770053
   Lajous M, 2012, DIABETES CARE, V35, P128, DOI 10.2337/dc11-1518
   Lescinsky H, 2022, NAT MED, V28, P2075, DOI 10.1038/s41591-022-01968-z
   Liu LJ, 2001, HYPERTENS RES, V24, P315, DOI 10.1291/hypres.24.315
   Lobo DM, 2015, EXP GERONTOL, V70, P97, DOI 10.1016/j.exger.2015.07.012
   Lv QF, 2015, ADV EXP MED BIOL, V803, P613, DOI 10.1007/978-3-319-15126-7_49
   Ma JR, 2022, TOXICOL MECH METHOD, V32, P420, DOI 10.1080/15376516.2021.2021579
   Matthews JJ, 2021, ADV NUTR, V12, P2216, DOI 10.1093/advances/nmab087
   Mizushima S, 1996, ADV EXP MED BIOL, V403, P615
   Mozaffari M, 2006, KIDNEY INT, V70, P329, DOI 10.1038/sj.ki.5001503
   Mozaffari MS, 2002, KIDNEY INT, V61, P1750, DOI 10.1046/j.1523-1755.2002.00317.x
   Murakami S, 2017, LIFE SCI, V186, P80, DOI 10.1016/j.lfs.2017.08.008
   Murakami S, 2015, MOL NUTR FOOD RES, V59, P1353, DOI 10.1002/mnfr.201500067
   Nandhini ATA, 2005, DIABETES METAB, V31, P337
   Nandhini ATA, 2004, ACTA PHYSIOL SCAND, V181, P297, DOI 10.1111/j.1365-201X.2004.01287.x
   Nandhini ATA, 2002, NUTR RES, V22, P343, DOI 10.1016/S0271-5317(01)00391-8
   Nardelli TR, 2011, AMINO ACIDS, V41, P901, DOI 10.1007/s00726-010-0789-7
   Nonaka H, 2001, CIRCULATION, V104, P1165, DOI 10.1161/hc3601.093976
   Pakulak A, 2022, J DIET SUPPL, V19, P587, DOI 10.1080/19390211.2021.1904085
   Peters V, 2020, CURR MED CHEM, V27, P1801, DOI 10.2174/0929867326666190326111851
   Qaradakhi T, 2020, NUTRIENTS, V12, DOI 10.3390/nu12092847
   Ra SG, 2019, ADV EXP MED BIOL, V1155, P407, DOI 10.1007/978-981-13-8023-5_38
   Rahman MM, 2011, AM J HYPERTENS, V24, P574, DOI 10.1038/ajh.2011.4
   Rogers ME, 2006, J SPORT SCI MED, V5, P60
   Rosa FT, 2014, EUR J NUTR, V53, P823, DOI 10.1007/s00394-013-0586-7
   Rosca AE, 2022, J CLIN MED, V11, DOI 10.3390/jcm11030666
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sang-Hoon L, 2004, DIABETES RES CLIN PR, V66, pS69, DOI 10.1016/j.diabres.2003.08.018
   Schaffer SW, 2009, CAN J PHYSIOL PHARM, V87, P91, DOI 10.1139/Y08-110
   Shi Y, 2022, AQUACULTURE, V554, DOI 10.1016/j.aquaculture.2022.738150
   Shimada K, 2015, ADV EXP MED BIOL, V803, P581, DOI 10.1007/978-3-319-15126-7_47
   Smith Rachel N, 2014, F1000Res, V3, P222, DOI 10.12688/f1000research.5218.1
   Song BC, 2014, NUTR RES PRACT, V8, P3, DOI 10.4162/nrp.2014.8.1.3
   STURMAN JA, 1975, J NEUROCHEM, V25, P831, DOI 10.1111/j.1471-4159.1975.tb04414.x
   Takenaga T, 2000, ADV EXP MED BIOL, V483, P187
   Tsuboyama-Kasaoka N, 2006, ENDOCRINOLOGY, V147, P3276, DOI 10.1210/en.2005-1007
   U.S. Department of Health and Human Services and U.S. Department of Agriculture, 2015, 20152020 dietary guidelines for Americans, V8th
   Willett W, 2019, LANCET, V393, P447, DOI 10.1016/S0140-6736(18)31788-4
   Wu G, 2016, J ANIM SCI, V94, P2603, DOI 10.2527/jas.2016-0478
   Wu GY, 2020, AMINO ACIDS, V52, P329, DOI 10.1007/s00726-020-02823-6
   Wu GY, 2013, AMINO ACIDS, V45, P407, DOI 10.1007/s00726-013-1500-6
   Wu N, 2010, DIABETES RES CLIN PR, V90, P288, DOI 10.1016/j.diabres.2010.08.020
   Wyss M, 2002, NEUROSCIENCE, V112, P243, DOI 10.1016/S0306-4522(02)00088-X
   Yamori Y, 2001, HYPERTENS RES, V24, P453, DOI 10.1291/hypres.24.453
   Yue C., 2015, Stud. Sci. Sci, V33, P242, DOI [DOI 10.16192/J.CNKI.1003-2053.2015.02.009, 10.16192/j.cnki.1003-2053.2015.02.009]
   Zhang M, 2004, AMINO ACIDS, V26, P267, DOI 10.1007/s00726-003-0059-z
   Zhang M, 2004, AMINO ACIDS, V26, P203, DOI 10.1007/s00726-003-0002-3
   Zhang XL, 2014, ACTA BIOCH BIOPH SIN, V46, P261, DOI 10.1093/abbs/gmu004
NR 97
TC 4
Z9 5
U1 4
U2 29
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2023
VL 15
IS 15
AR 3374
DI 10.3390/nu15153374
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA O7OZ5
UT WOS:001045673100001
PM 37571314
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Aldhafiri, FK
   Abdelgawad, FE
   Bakri, GMM
   Saber, T
AF Aldhafiri, Fahad Khalid
   Abdelgawad, Fathy Elsayed
   Bakri, Gihan Mohamed Mohamed
   Saber, Tamer
TI Thyroid Function Assessment in Saudi Males with Metabolic Syndrome
SO JOURNAL OF PHARMACY AND BIOALLIED SCIENCES
LA English
DT Article
DE Metabolic syndrome; Thyroid and thyroid dysfunction; LDL/HDL
   cholesterol; Obesity; Hypertension; Cardiovascular disease; Lipids (TG)
ID INSULIN-RESISTANCE; FREE-THYROXINE; SUBCLINICAL HYPOTHYROIDISM;
   COMPONENTS; ASSOCIATION; HORMONE; SERUM; RISK; TSH; DYSFUNCTION
AB Background: Metabolic Syndrome (MetS) is a multifactor condition associated with cardiovascular risk. Thyroid hormones regulate MetS components via controlling energy homeostasis, lipids, and glucose metabolism. The risk ratio for MetS and related disorders changes between males and females. Aim and Objectives: Study aim to access thyroid functions in Saudi population with metabolic syndrome. Materials and Methods: The current study sought to evaluate the impact of thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) in predicting the risk of MetS. A total of 200 (MetS 100 and control 100) Saudi Arabian males were enrolled for the study, and after applying eligibility criteria, the eligible study size was examined for the physical test (chest, abdominal, and general examination with stress on blood pressure measurement) and anthropometric parameters (bodyweight, body mass index, and waist circumference). Results: In the present study, the biochemical parameters, such as TSH, FT3, FT4, total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), high-density lipoprotein (LDL), fasting glucose, and fasting insulin were measured in the study group, and statistical analysis was also performed. The results revealed that the MetS and control differ in terms of physical, anthropometric, and biochemical markers. The study showed that thyroid dysfunction (TD) and MetS are closely associated with the difference in physical, anthropometric, and metabolic characteristics. Conclusion: The result demonstrated hypothyroidism major risk factor due to TD in MetS. These findings provide a scientific basis for diagnosis and the management of TD, associated MetS, and cardiovascular disease (CVD).
C1 [Aldhafiri, Fahad Khalid] Majmaah Univ Coll Appl Med Sci, Dept Publ Hlth, Al Majmaah, Saudi Arabia.
   [Abdelgawad, Fathy Elsayed] Al Azhar Univ, Fac Med, Med Biochem Dept, Cairo, Egypt.
   [Bakri, Gihan Mohamed Mohamed] Islamic Univ Madinah, Fac Sci, Dept Chem, Madinah, Saudi Arabia.
   [Bakri, Gihan Mohamed Mohamed] Univ Med Ctr, Islamic Univ Madinah, Madinah, Saudi Arabia.
   [Saber, Tamer] Zagazig Univ, Fac Med, Dept Internal Med, Zagazig, Egypt.
C3 Egyptian Knowledge Bank (EKB); Al Azhar University; Islamic University
   of Al Madinah; Islamic University of Al Madinah; Egyptian Knowledge Bank
   (EKB); Zagazig University
RP Aldhafiri, FK (corresponding author), Majmaah Univ Saudi Arabia, Appl Med Sci Coll, Publ Hlth Dept, Ind Area, Al Majmaah 15341, Saudi Arabia.
EM F.Aldhafiri@mu.edu.sa
RI Saber, Tamer/LCD-8882-2024; Abdelgawad, Fathy Elsayed/GQZ-7106-2022
OI Abdelgawad, Fathy Elsayed/0000-0002-4958-1761; Saber,
   Tamer/0000-0003-0163-2184
CR AbuAlhamael S, 2018, EGYPT J HOSP MED, V70, P1862
   Agarwal G, 2011, J CLIN DIAGN RES, V5, P213
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   ANDERSON BG, 1968, J AMER MED ASSOC, V203, P577, DOI 10.1001/jama.203.8.577
   [Anonymous], IDF CONS WORLD WID D
   [Anonymous], 2004, EVALUATION-US
   Bonora E, 2006, ANN MED, V38, P64, DOI 10.1080/07853890500401234
   BRODAL BP, 1971, EUR J BIOCHEM, V18, P201, DOI 10.1111/j.1432-1033.1971.tb01231.x
   Cameron AJ, 2008, J INTERN MED, V264, P177, DOI 10.1111/j.1365-2796.2008.01935.x
   Cerbone M, 2014, J CLIN ENDOCR METAB, V99, P2697, DOI 10.1210/jc.2014-1761
   Chang YC, 2019, J CLIN MED, V8, DOI 10.3390/jcm8060817
   Clin Lab Navigator, THYR FUNCT TESTS
   Garduño-Garcia JD, 2010, EUR J ENDOCRINOL, V163, P273, DOI 10.1530/EJE-10-0312
   Deshmukh V, 2018, INT J ENDOCRINOL, V2018, DOI 10.1155/2018/2930251
   Ding X, 2021, BMC ENDOCR DISORD, V21, DOI 10.1186/s12902-021-00703-y
   DULLAART RPF, 1990, EUR J CLIN INVEST, V20, P581, DOI 10.1111/j.1365-2362.1990.tb01904.x
   Glinoer D, 1997, ENDOCR REV, V18, P404, DOI 10.1210/er.18.3.404
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Gyawali P, 2015, DIABETES METAB J, V39, P66, DOI 10.4093/dmj.2015.39.1.66
   Hak AE, 2000, ANN INTERN MED, V132, P270, DOI 10.7326/0003-4819-132-4-200002150-00004
   Heima NE, 2013, EUR J ENDOCRINOL, V168, P59, DOI 10.1530/EJE-12-0375
   Iqbal A, 2006, J INTERN MED, V260, P53, DOI 10.1111/j.1365-2796.2006.01652.x
   Kalra Sanjay, 2011, Indian J Endocrinol Metab, V15, pS89, DOI 10.4103/2230-8210.83332
   Khatiwada Saroj, 2016, Clin Diabetes Endocrinol, V2, P3, DOI 10.1186/s40842-016-0021-0
   Kim BJ, 2009, CLIN ENDOCRINOL, V70, P152, DOI 10.1111/j.1365-2265.2008.03304.x
   Klein I, 2001, NEW ENGL J MED, V344, P501, DOI 10.1056/NEJM200102153440707
   Kota Sunil Kumar, 2012, Indian J Endocrinol Metab, V16, pS332, DOI 10.4103/2230-8210.104079
   Ladenson PW, 2001, ARCH INTERN MED, V161, P130
   Lai CC, 2011, INT J GERONTOL, V5, P25, DOI 10.1016/j.ijge.2011.01.005
   Lai YX, 2011, ENDOCR J, V58, P23, DOI 10.1507/endocrj.K10E-272
   Lee MK, 2019, ENDOCRINE, V65, P608, DOI 10.1007/s12020-019-01942-9
   Liu YY, 2010, TRENDS ENDOCRIN MET, V21, P166, DOI 10.1016/j.tem.2009.11.004
   Maratou E, 2010, EUR J ENDOCRINOL, V163, P625, DOI 10.1530/EJE-10-0246
   Maratou E, 2009, EUR J ENDOCRINOL, V160, P785, DOI 10.1530/EJE-08-0797
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Meher LK, 2013, Thyroid Res Pract, V10, P60, DOI [10.4103/0973-0354.110583, DOI 10.4103/0973-0354.110583]
   Mehran L, 2014, THYROID, V24, P1566, DOI 10.1089/thy.2014.0103
   Misra A, 2007, INDIAN J MED RES, V125, P345
   Misra A, 2009, METAB SYNDR RELAT D, V7, P497, DOI 10.1089/met.2009.0024
   Moebus Susanne, 2006, Ger Med Sci, V4, pDoc07
   Park SB, 2011, J KOREAN MED SCI, V26, P540, DOI 10.3346/jkms.2011.26.4.540
   Rajendra KC, 2015, J THROID RES, V2015, DOI 10.1155/2015/305241
   Rochon C, 2003, CLIN SCI, V104, P7, DOI 10.1042/CS20020154
   Roos A, 2007, J CLIN ENDOCR METAB, V92, P491, DOI 10.1210/jc.2006-1718
   Ruhla S, 2010, CLIN ENDOCRINOL, V72, P696, DOI 10.1111/j.1365-2265.2009.03698.x
   Schubert CC, 2006, J AM GERIATR SOC, V54, P104, DOI 10.1111/j.1532-5415.2005.00543.x
   Shantha GPS, 2009, THYROID RES, V2, DOI 10.1186/1756-6614-2-2
   Sharma SK, 2011, INT J HYPERTENS, V2011, DOI 10.4061/2011/821971
   Shlomo Melmed R, 2019, AG WILLIAMS TXB ENDO
   Singh BM, 2010, INDIAN J CLIN BIOCHE, V25, P141, DOI 10.1007/s12291-010-0026-x
   SPENCER CA, 1989, J CLIN IMMUNOASSAY, V12, P82
   Stanická S, 2005, CLIN CHEM LAB MED, V43, P715, DOI 10.1515/CCLM.2005.121
   Tarcin O, 2012, METAB SYNDR RELAT D, V10, P137, DOI 10.1089/met.2011.0098
   Tehrani FR, 2011, J DIABETES METAB, V2, DOI 10.4172/2155-6156.1000156
   Udenze I, 2014, PAN AFR MED J, V18, DOI 10.11604/pamj.2014.18.352.4551
   Uzunlulu M, 2007, ENDOCR J, V54, P71, DOI 10.1507/endocrj.K06-124
   van Tienhoven-Wind LJN, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-016-0403-4
   Wang CY, 2012, ENDOCR J, V59, P911, DOI 10.1507/endocrj.EJ12-0076
   Wang JY, 2010, J AM GERIATR SOC, V58, P1613, DOI 10.1111/j.1532-5415.2010.02998.x
   Waring AC, 2012, CLIN ENDOCRINOL, V76, P911, DOI 10.1111/j.1365-2265.2011.04328.x
NR 60
TC 3
Z9 3
U1 1
U2 1
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 0975-7406
J9 J PHARM BIOALLIED SC
JI J. Pharm. Bioallied Sci.
PD OCT-DEC
PY 2021
VL 13
IS 4
BP 352
EP 359
DI 10.4103/jpbs.jpbs_745_21
PG 8
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA 0P4US
UT WOS:000784217300003
PM 35399801
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cox, AJ
   Zhang, P
   Evans, TJ
   Scott, RJ
   Cripps, AW
   West, NP
AF Cox, Amanda J.
   Zhang, Ping
   Evans, Tiffany J.
   Scott, Rodney J.
   Cripps, Allan W.
   West, Nicholas P.
TI Gene expression profiles in whole blood and associations with metabolic
   dysregulation in obesity
SO OBESITY RESEARCH & CLINICAL PRACTICE
LA English
DT Article
DE Metabolic syndrome; Obesity; Gene expression; Pathway analysis
ID OXIDATIVE STRESS; ADIPOSE-TISSUE; RIBOSOME BIOGENESIS; TYPE-2; CELLS;
   INFLAMMATION
AB Background: Gene expression data provides one tool to gain further insight into the complex biological interactions linking obesity and metabolic disease. This study examined associations between blood gene expression profiles and metabolic disease in obesity.
   Methods: Whole blood gene expression profiles, performed using the lllumina HT- 12v4 Human Expression Beadchip, were compared between (i) individuals with obesity (O) or lean (L) individuals (n =21 each), (ii) individuals with (M) or without (H) Metabolic Syndrome (n = 11 each) matched on age and gender. Enrichment of differentially expressed genes (DEG) into biological pathways was assessed using Ingenuity Pathway Analysis. Association between sets of genes from biological pathways considered functionally relevant and Metabolic Syndrome were further assessed using an area under the curve (AUG) and cross-validated classification rate (CR).
   Results: For OvL, only 50 genes were significantly differentially expressed based on the selected differential expression threshold (1.2-fold, p < 0.05). For MvH, 582 genes were significantly differentially expressed (1.2-fold, p < 0 05) and pathway analysis revealed enrichment of DEG into a diverse set of pathways including immune/inflammatory control, insulin signalling and mitochondrial function pathways. Gene sets from the mTOR signalling pathways demonstrated the strongest association with Metabolic Syndrome (p = 8.1 x 10(-8); AUC: 0.909, CR: 72.7%).
   Conclusions: These results support the use of expression profiling in whole blood in the absence of more specific tissue types for investigations of metabolic disease. Using a pathway analysis approach it was possible to identify an enrichment of DEG into biological pathways that could be targeted for in vitro follow-up. (c) 2017 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
C1 [Cox, Amanda J.; Zhang, Ping; Cripps, Allan W.; West, Nicholas P.] Griffith Univ, Menzies Hlth Inst Queensland, Parklands Dr, Southport, Qld 4215, Australia.
   [Cox, Amanda J.; West, Nicholas P.] Griffith Univ, Sch Med Sci, Southport, Qld, Australia.
   [Evans, Tiffany J.; Scott, Rodney J.] Hunter Med Res Inst, Informat Based Med Res Program, Newcastle, NSW, Australia.
   [Evans, Tiffany J.; Scott, Rodney J.] Univ Newcastle, Sch Biomed Sci & Pharm, Newcastle, NSW, Australia.
   [Cripps, Allan W.] Griffith Univ, Sch Med, Southport, Qld, Australia.
C3 Griffith University; Griffith University - Gold Coast Campus; Griffith
   University; Griffith University - Gold Coast Campus; Hunter Medical
   Research Institute; University of Newcastle; University of Newcastle;
   Griffith University; Griffith University - Gold Coast Campus
RP Cox, AJ (corresponding author), Griffith Univ, Menzies Hlth Inst Queensland, Parklands Dr, Southport, Qld 4215, Australia.
EM a.cox@griffith.edu.au
RI EVANS, TIFFANY-JANE/G-8001-2013; zhang, ping/L-3901-2017; Scott,
   Rodney/B-2827-2013
OI West, Nicholas/0000-0002-5482-4182; zhang, ping/0000-0002-3907-1127;
   Zhang, Ping/0000-0001-9163-6191; Scott, Rodney/0000-0001-7724-3404
FU Griffith University Area of Strategic Investment in Chronic Disease
   Prevention
FX The authors would like to gratefully acknowledge the cooperation of the
   trial participants. The assistance of Ms Annabelle Watts (School of
   Medical Science, Griffith University) with participant management and
   RNA extractions is appreciated, as is the assistance of Dr. Andrew
   Bulmer (School of Medical Science, Griffith University) with the
   clinical chemistry analyses. Salary support for AJC and PZ was provided
   by the Griffith University Area of Strategic Investment in Chronic
   Disease Prevention.
CR Brigden ML, 1999, AM FAM PHYSICIAN, V60, P1443
   Colagiuri S, 2010, MED J AUSTRALIA, V192, P260, DOI 10.5694/j.1326-5377.2010.tb03503.x
   Cox AJ, 2015, LANCET DIABETES ENDO, V3, P207, DOI 10.1016/S2213-8587(14)70134-2
   Du P, 2008, BIOINFORMATICS, V24, P1547, DOI 10.1093/bioinformatics/btn224
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Ghosh S, 2010, BMC MED GENOMICS, V3, DOI 10.1186/1755-8794-3-56
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Homuth G, 2015, BMC MED GENOMICS, V8, DOI 10.1186/s12920-015-0141-x
   Jastrzebski K, 2007, GROWTH FACTORS, V25, P209, DOI 10.1080/08977190701779101
   Keller MP, 2010, ANNU REV NUTR, V30, P341, DOI 10.1146/annurev.nutr.012809.104747
   Kodama K, 2012, P NATL ACAD SCI USA, V109, P7049, DOI 10.1073/pnas.1114513109
   Kraan TCTMV, 2015, BMC MED GENOMICS, V8, DOI 10.1186/s12920-015-0096-y
   Leskinen T, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012609
   Lin SM, 2008, NUCLEIC ACIDS RES, V36, DOI 10.1093/nar/gkm1075
   Manoel-Caetano FS, 2012, GENE, V511, P151, DOI 10.1016/j.gene.2012.09.090
   Mao JH, 2011, BMC GENOMICS, V12, DOI 10.1186/1471-2164-12-S5-S12
   Mayer C, 2006, ONCOGENE, V25, P6384, DOI 10.1038/sj.onc.1209883
   Nilsson E, 2014, DIABETES, V63, P2962, DOI 10.2337/db13-1459
   Nyman E, 2014, J BIOL CHEM, V289, P33215, DOI 10.1074/jbc.M114.608927
   Park K, 2009, DIABETES CARE, V32, P1302, DOI 10.2337/dc09-0259
   Ritchie ME, 2015, NUCLEIC ACIDS RES, V43, DOI 10.1093/nar/gkv007
   Samaras K, 2010, OBESITY, V18, P884, DOI 10.1038/oby.2009.443
   Sreekumar R, 2002, DIABETES, V51, P1913, DOI 10.2337/diabetes.51.6.1913
   SWETS JA, 1988, SCIENCE, V240, P1285, DOI 10.1126/science.3287615
   Tangen SE, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0084002
   Tangvarasittichai S, 2015, WORLD J DIABETES, V6, P456, DOI 10.4239/wjd.v6.i3.456
   Väremo L, 2015, CELL REP, V11, P921, DOI 10.1016/j.celrep.2015.04.010
   Wang J, 2016, CELL SIGNAL, V28, P1099, DOI 10.1016/j.cellsig.2016.05.007
   Wang S, 2009, INT J OBESITY, V33, P481, DOI 10.1038/ijo.2008.277
NR 30
TC 5
Z9 5
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-403X
EI 1878-0318
J9 OBES RES CLIN PRACT
JI Obes. Res. Clin. Pract.
PD MAR-APR
PY 2018
VL 12
IS 2
BP 204
EP 213
DI 10.1016/j.orcp.2017.07.001
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA GG1LJ
UT WOS:000432448200009
PM 28755841
DA 2025-06-11
ER

PT J
AU Lemaster, KA
   Farid, Z
   Brock, RW
   Shrader, CD
   Goldman, D
   Jackson, DN
   Frisbee, JC
AF Lemaster, Kent A.
   Farid, Zahra
   Brock, Robert W.
   Shrader, Carl D.
   Goldman, Daniel
   Jackson, Dwayne N.
   Frisbee, Jefferson C.
TI Altered post-capillary and collecting venular reactivity in skeletal
   muscle with metabolic syndrome
SO JOURNAL OF PHYSIOLOGY-LONDON
LA English
DT Article
DE microcirculation; metabolic syndrome; skeletal muscle blood flow; venous
   function
ID RETINAL MICROVASCULAR SIGNS; PERFUSION HETEROGENEITY; INFLAMMATORY
   RESPONSES; ARTERIOLAR DIAMETER; RESISTANCE; HYPERTENSION; ASSOCIATIONS;
   MECHANISMS; VESSELS; IMPACT
AB While research into vascular outcomes of the metabolic syndrome has focused on arterial/arteriolar and capillary levels, investigation into venular function and how this impacts responses has received little attention. Using the in situ cremaster muscle of obese Zucker rats (OZR; with lean Zucker rats (LZR) as controls), we determined indices of venular function. At approximate to 17weeks of age, skeletal muscle post-capillary venular density was reduced by approximate to 20% in LZR vs. OZR, although there was no evidence of remodelling of the venular wall. Venular tone at approximate to 25m (post-capillary) and approximate to 75m (collecting) diameter was elevated in OZR vs. LZR. Venular dilatation to acetylcholine was blunted in OZR vs. LZR due to increased oxidant stress-based loss of nitric oxide bioavailability (post-capillary) and increased (1)- (and (2)-) mediated constrictor tone (collecting). Venular constrictor responses in OZR were comparable to LZR for most stimuli, although constriction to (1)-adrenoreceptor stimulation was elevated. In response to field stimulation of the cremaster muscle (0.5, 1, 3Hz), venular dilator and hyperaemic responses to lower frequencies were blunted in OZR, but responses at 3Hz were similar between strains. Venous production of TxA(2) was higher in OZR than LZR and significantly higher than PGI(2) production in either following arachidonic acid challenge. These results suggest that multi-faceted alterations to skeletal muscle venular function in OZR may contribute to alterations in upstream capillary pressure profiles and the transcapillary exchange of solutes and water under conditions of metabolic syndrome.
C1 [Lemaster, Kent A.; Farid, Zahra; Goldman, Daniel; Jackson, Dwayne N.; Frisbee, Jefferson C.] Univ Western Ontario, Schulich Sch Med & Dent, Dept Med Biophys, Transdisciplinary Program Vasc Hlth, London, ON, Canada.
   [Brock, Robert W.] West Virginia Univ HSC, Dept Physiol & Pharmacol, Morgantown, WV USA.
   [Shrader, Carl D.] West Virginia Univ HSC, Family Med, Morgantown, WV USA.
C3 Western University (University of Western Ontario)
RP Frisbee, JC (corresponding author), Western Univ, Dept Med Biophys, Schulich Sch Med & Dent, MSB 407, London, ON N6A 5C1, Canada.
EM jfrisbee@uwo.ca
RI Jackson, Dwayne/E-4153-2015; Goldman, Daniel/CAI-2887-2022
OI Goldman, Daniel/0000-0002-8707-5536; Frisbee,
   Jefferson/0000-0003-2751-0599
FU American Heart Association [IRG 14330015, EIA 0740129N]; National
   Institutes of Health [RR 2865AR, P20 RR 016477, R01 DK64668, R01
   DK67582]; Canadian Natural Sciences and Engineering Research Council
   [NSERC R4081A03, R4218A03]
FX This study was supported by the American Heart Association (IRG
   14330015, EIA 0740129N), the National Institutes of Health (RR 2865AR;
   P20 RR 016477, R01 DK64668, R01 DK67582) and the Canadian Natural
   Sciences and Engineering Research Council (NSERC R4081A03, R4218A03).
CR [Anonymous], HDB PHYSL 2
   [Anonymous], BR J CLIN PHARM
   [Anonymous], 2017, About Metabolic Syndrome
   BAKER M, 1974, MICROVASC RES, V7, P131, DOI 10.1016/0026-2862(74)90043-0
   Butcher JT, 2014, MICROCIRCULATION, V21, P677, DOI 10.1111/micc.12146
   Butcher JT, 2013, AM J PHYSIOL-HEART C, V304, pH547, DOI 10.1152/ajpheart.00805.2012
   CATELLA F, 1986, P NATL ACAD SCI USA, V83, P5861, DOI 10.1073/pnas.83.16.5861
   Clough GF, 2015, COMPR PHYSIOL, V5, P397, DOI 10.1002/cphy.c140037
   Danaei G, 2014, LANCET DIABETES ENDO, V2, P634, DOI 10.1016/S2213-8587(14)70102-0
   DAVIS MJ, 1987, MICROVASC RES, V34, P223, DOI 10.1016/0026-2862(87)90055-0
   Estato V, 2017, METAB SYNDR RELAT D, V15, P26, DOI 10.1089/met.2016.0085
   Frisbee JC, 2006, ESSAYS BIOCHEM, V42, P145, DOI 10.1042/bse0420145
   Frisbee JC, 2016, AM J PHYSIOL-HEART C, V310, pH488, DOI 10.1152/ajpheart.00790.2015
   Frisbee JC, 2014, AM J PHYSIOL-HEART C, V307, pH1714, DOI 10.1152/ajpheart.00605.2014
   Gilbert RE, 2013, CIRC J, V77, P849, DOI 10.1253/circj.CJ-13-0236
   Goodwill AG, 2008, AM J PHYSIOL-HEART C, V295, pH1522, DOI 10.1152/ajpheart.00596.2008
   Goodwill AG, 2012, VASC PHARMACOL, V57, P150, DOI 10.1016/j.vph.2012.07.002
   GREENE AS, 1990, HYPERTENSION, V15, P779, DOI 10.1161/01.HYP.15.6.779
   HARRIS AG, 1994, INT J MICROCIRC, V14, P159, DOI 10.1159/000178824
   HARRIS AG, 1993, AM J PHYSIOL, V264, pH909, DOI 10.1152/ajpheart.1993.264.3.H909
   Hester RL, 2002, AM J PHYSIOL-REG I, V282, pR1280, DOI 10.1152/ajpregu.00744.2001
   Huxley VH, 2011, J PHYSIOL-LONDON, V589, P2935, DOI 10.1113/jphysiol.2011.208298
   Iba T, 2012, THROMB RES, V129, pE246, DOI 10.1016/j.thromres.2012.03.001
   Lammert A, 2012, OBESITY, V20, P2262, DOI 10.1038/oby.2012.122
   Lemaster K, 2017, MICROCIRCULATION, V24, DOI 10.1111/micc.12332
   Lipowsky H H, 1988, Adv Exp Med Biol, V242, P85
   Liu YP, 1997, AM J PHYSIOL-HEART C, V273, pH869, DOI 10.1152/ajpheart.1997.273.2.H869
   LUU TN, 1992, BRIT HEART J, V67, P474
   Mameli C, 2017, PHARMACOL RES, V119, P99, DOI 10.1016/j.phrs.2017.01.017
   McKay MK, 1998, HYPERTENSION, V31, P213, DOI 10.1161/01.HYP.31.1.213
   MELLANDER S, 1963, CIRC RES, V13, P105, DOI 10.1161/01.RES.13.2.105
   Morris T, 2009, J IMMUNOL, V183, P2089, DOI 10.4049/jimmunol.0900477
   MRAZKOVA O, 1986, AM J ANAT, V177, P141, DOI 10.1002/aja.1001770203
   NIES AS, 1986, CLIN PHARMACOL THER, V39, P481, DOI 10.1038/clpt.1986.84
   Pongor E, 2010, ACTA VET HUNG, V58, P177, DOI 10.1556/AVet.58.2010.2.4
   Saito Yuichiro, 1994, American Journal of Physiology, V267, pH1227
   Scallan JP, 2015, CARDIOVASC RES, V107, P89, DOI 10.1093/cvr/cvv117
   Shamseddeen H, 2011, SURG CLIN N AM, V91, P1163, DOI 10.1016/j.suc.2011.08.001
   Singer G, 2009, SHOCK, V31, P275, DOI 10.1097/SHK.0b013e3181834ab3
   TABRIZCHI R, 1992, CARDIOVASC RES, V26, P443, DOI 10.1093/cvr/26.5.443
   Tole S, 2010, AM J PHYSIOL-CELL PH, V298, pC1469, DOI 10.1152/ajpcell.00380.2009
   Totani L, 2012, THROMB HAEMOSTASIS, V107, P1130, DOI 10.1160/TH11-12-0867
   Trasande L, 2012, EXPERT REV PHARM OUT, V12, P39, DOI [10.1586/erp.11.93, 10.1586/ERP.11.93]
   Tune JD, 2017, TRANSL RES, V183, P57, DOI 10.1016/j.trsl.2017.01.001
   TYML K, 1991, INT J MICROCIRC, V10, P335
   Vassallo P, 2016, PROG CARDIOVASC DIS, V59, P172, DOI 10.1016/j.pcad.2016.07.012
   Wong TY, 2004, INVEST OPHTH VIS SCI, V45, P2949, DOI 10.1167/iovs.04-0069
   Xiang LH, 2006, AM J PHYSIOL-REG I, V290, pR134, DOI 10.1152/ajpregu.00295.2005
   ZEINTL H, 1989, INT J MICROCIRC, V8, P293
   Zhao Y, 2012, GRAEF ARCH CLIN EXP, V250, P1755, DOI 10.1007/s00417-012-2109-2
   Zou MH, 2007, PROSTAG OTH LIPID M, V82, P119, DOI 10.1016/j.prostaglandins.2006.05.005
NR 51
TC 8
Z9 8
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3751
EI 1469-7793
J9 J PHYSIOL-LONDON
JI J. Physiol.-London
PD AUG 1
PY 2017
VL 595
IS 15
BP 5159
EP 5174
DI 10.1113/JP274291
PG 16
WC Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Physiology
GA FC2VX
UT WOS:000406698100015
PM 28556909
OA Green Published
DA 2025-06-11
ER

PT J
AU Kabir, F
   Nahar, K
   Rahman, MM
   Mamun, F
   Lasker, S
   Khan, F
   Yasmin, T
   Akter, KA
   Subhan, N
   Alam, MA
AF Kabir, Fariha
   Nahar, Kamrun
   Rahman, Md Mizanur
   Mamun, Fariha
   Lasker, Shoumen
   Khan, Ferdous
   Yasmin, Tahmina
   Akter, Khondker Ayesha
   Subhan, Nusrat
   Alam, Md Ashraful
TI Etoricoxib treatment prevented body weight gain and ameliorated
   oxidative stress in the liver of high-fat diet-fed rats
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Etoricoxib; Obesity; COX-2; Metabolic syndrome; Inflammation; Oxidative
   stress
ID INSULIN-RESISTANCE; CYCLOOXYGENASE-2 INHIBITORS; CARBON-TETRACHLORIDE;
   IMMUNE CELLS; OBESITY; GLUCOSE; MICE; INFLAMMATION; CHOLESTEROL;
   CELECOXIB
AB The main focus of this study was to determine the role of etoricoxib in counterbalancing the oxidative stress, metabolic disturbances, and inflammation in high-fat (HF) diet-induced obese rats. To conduct this study, 28 male Wistar rats (weighing 190-210 g) were distributed randomly into four groups: control, control + etoricoxib, HF, and HF + etoricoxib. After 8 weeks of treatment with etoricoxib (200 mg/kg), all the animals were sacrificed followed by the collection of blood and tissue samples in order to perform biochemical tests along with histological staining on hepatic tissues. According to this study, etoricoxib treatment prevented the body weight gain in HF diet-fed rats. Furthermore, rats of HF + etoricoxib group exhibited better blood glucose tolerance than the rats of HF diet-fed group. In addition, etoricoxib also markedly normalized HF diet-mediated rise of hepatic enzyme activity. Etoricoxib treatment lowered the level of oxidative stress indicators significantly with a parallel augmentation of antioxidant enzyme activities. Furthermore, etoricoxib administration helped in preventing inflammatory cell invasion, collagen accumulation, and fibrotic catastrophe in HF diet-fed rats. The findings of the present work are suggestive of the helpful role of etoricoxib in deterring the metabolic syndrome as well as other deleterious pathological changes afflicting the HF diet-fed rats.
C1 [Kabir, Fariha; Nahar, Kamrun; Rahman, Md Mizanur; Mamun, Fariha; Lasker, Shoumen; Khan, Ferdous; Yasmin, Tahmina; Akter, Khondker Ayesha; Subhan, Nusrat; Alam, Md Ashraful] North South Univ, Dept Pharmaceut Sci, Dhaka 1219, Bangladesh.
C3 North South University (NSU)
RP Alam, MA (corresponding author), North South Univ, Dept Pharmaceut Sci, Dhaka 1219, Bangladesh.
EM sonaliagun@yahoo.com
RI Mamun, Fariha/AAR-7070-2020; Nahar, Dr.Kamrun/JFS-9212-2023; Khan,
   Ferdous/MDS-9680-2025; Alam, Ashraful/G-1964-2014; Rahman, Md
   Mizanur/AAC-7666-2019
OI Kabir, Fariha/0000-0001-6412-5257; Alam, Md
   Ashraful/0000-0001-7596-5868; Rahman, Md Mizanur/0000-0002-7178-7977
FU Department of Pharmaceutical Sciences, North South University,
   Bangladesh
FX The authors appreciate all the supports provided by the Department of
   Pharmaceutical Sciences, North South University, Bangladesh, where the
   research work was conducted.
CR Alkhouri Naim, 2009, Expert Rev Gastroenterol Hepatol, V3, P445, DOI 10.1586/egh.09.32
   Arriazu E, 2014, ANTIOXID REDOX SIGN, V21, P1078, DOI 10.1089/ars.2013.5697
   Bäck M, 2012, EUR HEART J, V33, P1928, DOI 10.1093/eurheartj/ehr421
   Bagi Zsolt, 2006, Pharmacol Rep, V58 Suppl, P52
   Bais S, 2014, ADV BIOL, V2014, DOI 10.1155/2014/162914
   Bolduc C, 2004, OBES RES, V12, P750, DOI 10.1038/oby.2004.90
   Burhans MS, 2019, COMPR PHYSIOL, V9, P1, DOI 10.1002/cphy.c170040
   Cannon CP, 2006, LANCET, V368, P1771, DOI 10.1016/S0140-6736(06)69666-9
   Chávez E, 2012, J APPL TOXICOL, V32, P51, DOI 10.1002/jat.1638
   Chávez E, 2010, LIVER INT, V30, P969, DOI 10.1111/j.1478-3231.2010.02256.x
   Choi Y, 2016, J NUTR BIOCHEM, V38, P70, DOI 10.1016/j.jnutbio.2016.08.013
   Chooi YC, 2019, METABOLISM, V92, P6, DOI 10.1016/j.metabol.2018.09.005
   Ekor M, 2013, DRUG CHEM TOXICOL, V36, P1, DOI 10.3109/01480545.2011.642380
   Faghihimani E, 2013, ACTA DIABETOL, V50, P537, DOI 10.1007/s00592-011-0329-2
   Ferrante AW, 2013, DIABETES OBES METAB, V15, P34, DOI 10.1111/dom.12154
   Guilherme A, 2008, NAT REV MOL CELL BIO, V9, P367, DOI 10.1038/nrm2391
   Hawley SA, 2012, SCIENCE, V336, P918, DOI 10.1126/science.1215327
   Hermann M, 2003, CIRCULATION, V108, P2308, DOI 10.1161/01.CIR.0000101683.30157.0B
   Hsieh P-S, 2011, OBESITY INDUCED ADIP
   Hsieh PS, 2009, OBESITY, V17, P1150, DOI 10.1038/oby.2008.674
   Hu YP, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/4123854
   Hung CS, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0112355
   Hurt Ryan T, 2010, Gastroenterol Hepatol (N Y), V6, P780
   Kendig EL, 2008, BIOCHEM PHARMACOL, V76, P216, DOI 10.1016/j.bcp.2008.05.001
   KHAN RA, 2012, BMC COMPLEM ALTERN M, V12
   Lasker S, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-56538-0
   Libby P, 2002, CIRCULATION, V105, P1135, DOI 10.1161/hc0902.104353
   Liu TT, 2009, CHINESE J PHYSIOL, V52, P65, DOI 10.4077/CJP.2009.AMH034
   Matsumoto AK, 2002, J RHEUMATOL, V29, P1623
   McAdam BF, 1999, P NATL ACAD SCI USA, V96, P272, DOI 10.1073/pnas.96.1.272
   Mells JE, 2015, J NUTR BIOCHEM, V26, P285, DOI 10.1016/j.jnutbio.2014.11.002
   MISRA HP, 1972, J BIOL CHEM, V247, P3170
   Moraes B. Medeiros, 2007, Inflammopharmacology, V15, P175, DOI 10.1007/s10787-006-1581-x
   Mraz M, 2014, J ENDOCRINOL, V222, pR113, DOI 10.1530/JOE-14-0283
   Must A, 2006, INT J OBESITY, V30, P590, DOI 10.1038/sj.ijo.0803300
   Nie L, 2017, EBIOMEDICINE, V23, P136, DOI 10.1016/j.ebiom.2017.08.004
   NIEHAUS WG, 1968, EUR J BIOCHEM, V6, P126, DOI 10.1111/j.1432-1033.1968.tb00428.x
   Panchal SK, 2011, J CARDIOVASC PHARM, V57, P51, DOI [10.1097/FJC.0b013e3181feb90a, 10.1097/FJC.0b013e31821b1379]
   Pitt B, 2002, CIRCULATION, V106, P167, DOI 10.1161/01.CIR.0000025261.58465.62
   Pontsler AV, 2002, J BIOL CHEM, V277, P13029, DOI 10.1074/jbc.M109546200
   Rahman MM, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0539-x
   Rosin O, 2008, J ECON SURV, V22, P617, DOI 10.1111/j.1467-6419.2007.00544.x
   Rytka JM, 2011, DIABETES, V60, P56, DOI 10.2337/db10-0697
   Schmidt MI, 2003, CLIN CHEM LAB MED, V41, P1120, DOI 10.1515/CCLM.2003.174
   Shikora SA, 2005, JPEN-PARENTER ENTER, V29, P288, DOI 10.1177/0148607105029004288
   Smith BK, 2016, DIABETES, V65, P3352, DOI 10.2337/db16-0564
   SURWIT RS, 1988, DIABETES, V37, P1163, DOI 10.2337/diabetes.37.9.1163
   Tiwari Brahm Kumar, 2014, ISRN Pharmacol, V2014, P608590, DOI 10.1155/2014/608590
   TRACEY WR, 1995, J PHARMACOL EXP THER, V272, P1011
   Ulla A, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1799-8
   White PAS, 2013, ARQ BRAS ENDOCRINOL, V57, P339, DOI 10.1590/S0004-27302013000500002
   WitkoSarsat V, 1996, KIDNEY INT, V49, P1304, DOI 10.1038/ki.1996.186
   World Health Organization, 2021, Obesity and overweight, fact sheet
   Yan HY, 2003, J LIPID RES, V44, P424, DOI 10.1194/jlr.M200357-JLR200
   Yang JCZ, 2019, NUTRIENTS, V11, DOI 10.3390/nu11040872
   Yu J, 2006, HEPATOLOGY, V43, P826, DOI 10.1002/hep.21108
NR 56
TC 5
Z9 5
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD JAN
PY 2021
VL 394
IS 1
BP 33
EP 47
DI 10.1007/s00210-020-01960-9
EA AUG 2020
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA PN1PW
UT WOS:000558624900002
PM 32780227
DA 2025-06-11
ER

PT J
AU Catoi, AF
   Pârvu, AE
   Andreicut, AD
   Mironiuc, A
   Craciun, A
   Catoi, C
   Pop, ID
AF Catoi, Adriana Florinela
   Parvu, Alina Elena
   Andreicut, Andra Diana
   Mironiuc, Aurel
   Craciun, Alexandra
   Catoi, Cornel
   Pop, Ioana Delia
TI Metabolically Healthy versus Unhealthy Morbidly Obese: Chronic
   Inflammation, Nitro-Oxidative Stress, and Insulin Resistance
SO NUTRIENTS
LA English
DT Article
DE metabolically healthy morbidly obese; metabolically unhealthy morbidly
   obese; metabolic syndrome; chronic inflammation; nitro-oxidative stress;
   insulin-resistance
ID BARIATRIC SURGERY; ADIPOSE-TISSUE; NORMAL-WEIGHT; RISK-FACTORS;
   INDIVIDUALS; CHEMERIN; PREVALENCE; MECHANISMS; BIOMARKERS; ADIPOKINE
AB Metabolically heathy obesity is characterised by the presence of obesity in the absence of metabolic disturbances. The aim of our study was to analyse pro-inflammatory, nitro-oxidative stress, and insulin-resistance (IR) markers in metabolically healthy morbidly obese (MHMO) with respect to metabolically unhealthy morbidly obese (MUHMO) with metabolic syndrome (MS) and to identify the potential predictors of MS in the MHMO group. Two groups of MHMO and MUHMO with MS were analysed. We evaluated serum high sensitivity C reactive protein (hsCRP), tumor necrosis factor alpha (TNF-), chemerin, nitrite and nitrate (NOx), total oxidant status (TOS), total antioxidant response (TAR), fasting blood glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR.) MHMO have similar hsCRP and TNF- values as the MUHMO with MS, while chemerin was significantly lower in MHMO. NOx was higher in MUHMO with MS patients, while no difference regarding TOS and TAR was found between the two groups. HOMA-IR and insulin values were lower in MHMO as compared to the MUHMO with MS group. Insulin, HOMA-IR, and chemerin were identified predictors of MS in MHMO. In conclusion, MHMO and MUHMO display similarities and differences in terms of chronic inflammation, nitro-oxidative stress, and IR. Markers of IR and chemerin are possible predictors of MS in MHMO.
C1 [Catoi, Adriana Florinela; Parvu, Alina Elena; Andreicut, Andra Diana] Iuliu Hatieganu Univ Med & Pharm, Fac Med, Dept Pathophysiol, Cluj Napoca 400012, Romania.
   [Mironiuc, Aurel] Iuliu Hatieganu Univ Med & Pharm, Fac Med, Surg Clin 2, Cluj Napoca 400012, Romania.
   [Craciun, Alexandra] Iuliu Hatieganu Univ Med & Pharm, Fac Med, Dept Biochem, Cluj Napoca 400012, Romania.
   [Catoi, Cornel] Univ Agr Sci & Vet Med, Fac Vet Med, Dept Pathol, Cluj Napoca 400012, Romania.
   [Pop, Ioana Delia] Univ Agr Sci & Vet Med, Fac Hort, Dept Exact Sci, Cluj Napoca 400012, Romania.
C3 Iuliu Hatieganu University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy; Iuliu Hatieganu University of
   Medicine & Pharmacy; University of Agricultural Sciences & Veterinary
   Medicine Cluj Napoca; University of Agricultural Sciences & Veterinary
   Medicine Cluj Napoca
RP Catoi, AF (corresponding author), Iuliu Hatieganu Univ Med & Pharm, Fac Med, Dept Pathophysiol, Cluj Napoca 400012, Romania.
EM florinela12@yahoo.com; parvualinaelena@umfcluj.ro;
   cecan.andra@umfcluj.ro; aurel.mironiuc@umfcluj.ro; acraciun@umfcluj.ro;
   cornel.catoi@usamvcluj.ro; popioana@usamvcluj.ro
RI Cornel, Catoi/KLC-4257-2024; POP, Ioana/C-3717-2008; Craciun, Alexandra
   M/G-5762-2011
OI Pop, Ioana Delia/0000-0002-6167-8232; Craciun, Alexandra
   M/0000-0003-3703-1874; Parvu, Alina Elena/0000-0001-8937-8517
FU European Social Fund, Human Resources Development Operational Programme
   2007-2013 [POSDRU/159/1.5/S/138776]; "Iuliu Hatieganu" University of
   Medicine and Pharmacy, Cluj-Napoca, Romania [27020/39/15.11.2011]
FX This research was funded by the European Social Fund, Human Resources
   Development Operational Programme 2007-2013, project no.
   POSDRU/159/1.5/S/138776 and by internal research grant no.
   27020/39/15.11.2011 of "Iuliu Hatieganu" University of Medicine and
   Pharmacy, Cluj-Napoca, Romania.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alfadda AA, 2014, INT J ENDOCRINOL, V2014, DOI 10.1155/2014/170434
   Antonopoulos AS, 2017, CARDIOVASC RES, V113, P1074, DOI 10.1093/cvr/cvx106
   Appleton SL, 2013, DIABETES CARE, V36, P2388, DOI 10.2337/dc12-1971
   Bañuls C, 2017, INT J OBESITY, V41, P1556, DOI 10.1038/ijo.2017.147
   Bell JA, 2014, OBES REV, V15, P504, DOI 10.1111/obr.12157
   Blüher M, 2014, EUR J ENDOCRINOL, V171, pR209, DOI 10.1530/EJE-14-0540
   Bondia-Pons I, 2012, J PHYSIOL BIOCHEM, V68, P701, DOI 10.1007/s13105-012-0154-2
   Bozaoglu K, 2007, ENDOCRINOLOGY, V148, P4687, DOI 10.1210/en.2007-0175
   Brochu M, 2001, J CLIN ENDOCR METAB, V86, P1020, DOI 10.1210/jc.86.3.1020
   Catalán V, 2015, GENES NUTR, V10, DOI 10.1007/s12263-015-0460-8
   Catoi Adriana Florinela, 2014, Clujul Med, V87, P19, DOI 10.15386/cjm.2014.8872.871.afc1
   Catoi AF, 2013, OBES SURG, V23, P1858, DOI 10.1007/s11695-013-0968-1
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Codoñer-Franch P, 2011, ATHEROSCLEROSIS, V215, P475, DOI 10.1016/j.atherosclerosis.2010.12.035
   De Lorenzo A, 2018, CURR DIABETES REV, V14, P405, DOI 10.2174/1573399813666170502105859
   De Lorenzo A, 2016, WORLD J GASTROENTERO, V22, P681, DOI 10.3748/wjg.v22.i2.681
   Eckel N, 2016, EUR J PREV CARDIOL, V23, P956, DOI 10.1177/2047487315623884
   Fatima SS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057113
   Francisqueti FV, 2017, REV ASSOC MED BRAS, V63, P85
   Goday A, 2014, SURG OBES RELAT DIS, V10, P871, DOI 10.1016/j.soard.2014.04.022
   Gómez-Ambrosi J, 2014, DIABETES CARE, V37, P2813, DOI 10.2337/dc14-0937
   Gonçalves CG, 2016, NUTRITION, V32, P14, DOI 10.1016/j.nut.2015.07.010
   Goralski KB, 2007, J BIOL CHEM, V282, P28175, DOI 10.1074/jbc.M700793200
   Hamer M, 2012, J CLIN ENDOCR METAB, V97, P2482, DOI 10.1210/jc.2011-3475
   Haskins IN, 2018, SURG OBES RELAT DIS, V14, P342, DOI 10.1016/j.soard.2017.11.032
   Molli AEI, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0190528
   Jung CH, 2017, KOREAN J INTERN MED, V32, P611, DOI 10.3904/kjim.2016.259
   Jung CH, 2016, OBESITY, V24, P1373, DOI 10.1002/oby.21483
   Karelis AD, 2005, J CLIN ENDOCR METAB, V90, P4145, DOI 10.1210/jc.2005-0482
   Lee CJ, 2015, SURG OBES RELAT DIS, V11, P142, DOI 10.1016/j.soard.2014.06.012
   Li YG, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0111707
   Lwow F, 2011, MENOPAUSE, V18, P646, DOI 10.1097/gme.0b013e3182038ec1
   Marques-Vidal P, 2012, EUR J CLIN NUTR, V66, P426, DOI 10.1038/ejcn.2011.170
   Mathew H, 2016, METABOLISM, V65, P73, DOI 10.1016/j.metabol.2015.10.019
   Maury E, 2010, MOL CELL ENDOCRINOL, V314, P1, DOI 10.1016/j.mce.2009.07.031
   Mongraw-Chaffin M, 2016, J CLIN ENDOCR METAB, V101, P4117, DOI 10.1210/jc.2016-2460
   Nguyen NT, 2017, NAT REV GASTRO HEPAT, V14, P160, DOI 10.1038/nrgastro.2016.170
   Ortega FB, 2016, CIRC RES, V118, P1752, DOI 10.1161/CIRCRESAHA.115.306883
   Pelascini E, 2016, SURG OBES RELAT DIS, V12, P49, DOI 10.1016/j.soard.2015.04.024
   Phillips CM, 2013, J CLIN ENDOCR METAB, V98, pE1610, DOI 10.1210/jc.2013-2038
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   Ress C, 2010, EUR J CLIN INVEST, V40, P277, DOI 10.1111/j.1365-2362.2010.02255.x
   Shin MJ, 2006, INT J OBESITY, V30, P1529, DOI 10.1038/sj.ijo.0803304
   Sjöström L, 2012, JAMA-J AM MED ASSOC, V307, P56, DOI 10.1001/jama.2011.1914
   Stefan N, 2008, ARCH INTERN MED, V168, P1609, DOI 10.1001/archinte.168.15.1609
   Stefan N, 2018, LANCET DIABETES ENDO, V6, P249, DOI 10.1016/S2213-8587(17)30292-9
   Tinahones FJ, 2009, OBESITY, V17, P240, DOI 10.1038/oby.2008.536
   van Beek L, 2014, METABOLISM, V63, P492, DOI 10.1016/j.metabol.2013.12.002
   van Vliet-Ostaptchouk JV, 2014, BMC ENDOCR DISORD, V14, DOI 10.1186/1472-6823-14-9
   Vincent HK, 2006, INT J OBESITY, V30, P400, DOI 10.1038/sj.ijo.0803177
   Weigert J, 2010, CLIN ENDOCRINOL, V72, P342, DOI 10.1111/j.1365-2265.2009.03664.x
   Wildman RP, 2008, ARCH INTERN MED, V168, P1617, DOI 10.1001/archinte.168.15.1617
   Wildman RP, 2011, OBESITY, V19, P1482, DOI 10.1038/oby.2010.332
   Xu XJ, 2012, J LIPID RES, V53, P792, DOI 10.1194/jlr.P022905
NR 56
TC 63
Z9 66
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2018
VL 10
IS 9
AR 1199
DI 10.3390/nu10091199
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GY5YI
UT WOS:000448659900072
PM 30200422
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Fernandes, R
   Bento, CF
   Matafome, P
   Sena, CM
   Seiça, RM
   Pereira, P
AF Fernandes, Rosa
   Bento, Carla F.
   Matafome, Paulo
   Sena, Cristina M.
   Seica, Raquel M.
   Pereira, Paulo
TI Atorvastatin-mediated protection of the retina in a model of diabetes
   with hyperlipidemia
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE diabetic retinopathy; statins; proteasome; oxidative stress; atherogenic
   diet
ID UBIQUITIN-PROTEASOME PATHWAY; GOTO-KAKIZAKI RAT; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; ENDOTHELIAL-CELLS; METABOLIC SYNDROME; RETINOPATHY;
   GLUCOSE; DEGRADATION; STATINS
AB Insulin resistance, a key feature of obesity, metabolic syndrome, and type 2 diabetes mellitus (T2DM), results in a variety of metabolic and vascular abnormalities. Metabolic disturbances associated with diabetes could contribute to disrupting the structural and (or) functional integrity of the retina. The effects of atorvastatin on retinal cells in hyperlipidemic T2DM rats have not yet been investigated. We used Goto-Kakizaki (GK) rats fed with an atherogenic diet (AD) for 4 months to investigate whether atorvastatin (administered for 1 month) would slow-down or reverse the progression of lesions in the diabetic retina. Fluorogenic substrates were used to measure the proteasome activities in retinal cells. The production of reactive oxygen species was determined by immunofluorescence in frozen retina sections, using dihydroethydium. Nitrotyrosine levels were assessed using immunohistochemistry. Protein levels of ubiquitin conjugates, free ubiquitin, and ubiquitin activating enzyme E1 were determined with Western blotting. Atorvastatin significantly reduced the levels of oxidative stress that were induced by the AD and restored the proteasome activities in the diabetic GK rats. Atorvastatin therapy significantly improved local oxidative stress levels in GK rats fed with AD. Atorvastatin can, at least in part, restore the ubiquitin proteasome system, and may represent a pharmacological approach to prevent some of the complications associated with diabetic retinopathy.
C1 [Fernandes, Rosa; Bento, Carla F.; Pereira, Paulo] Univ Coimbra, Fac Med, Inst Biomed Imaging & Life Sci IBILI, Ctr Opththalmol & Vis Sci, P-3000548 Coimbra, Portugal.
   [Fernandes, Rosa] Univ Coimbra, Fac Med, Inst Biomed Imaging & Life Sci IBILI, Lab Pharmacol & Expt Therapeut, P-3000548 Coimbra, Portugal.
   [Matafome, Paulo; Sena, Cristina M.; Seica, Raquel M.] Univ Coimbra, Fac Med, Inst Biomed Imaging & Life Sci IBILI, Physiol Lab, P-3000548 Coimbra, Portugal.
C3 Universidade de Coimbra; Universidade de Coimbra; Universidade de
   Coimbra
RP Fernandes, R (corresponding author), Univ Coimbra, Fac Med, Inst Biomed Imaging & Life Sci IBILI, Ctr Opththalmol & Vis Sci, P-3000548 Coimbra, Portugal.
EM rcfernandes@fmed.uc.pt
RI Pereira, Paulo/AAD-8375-2022; Matafome, Paulo/AAQ-4113-2020; Sena,
   Cristina/N-2494-2013; Fernandes, Rosa/P-1102-2014
OI Pereira, Paulo/0000-0002-9908-2290; Seica, Raquel/0000-0002-8378-0895;
   Matafome, Paulo/0000-0002-3422-290X; Sena, Cristina/0000-0002-0889-2977;
   Fernandes, Rosa/0000-0001-7828-2296; Bento, Carla F./0000-0001-8377-4543
FU Portuguese Foundation for Science and Technology (FCT)
   [PTDC/SAU-ORG/113542/2009, Pest-C/SAU/UI3282/2011]; Fundação para a
   Ciência e a Tecnologia [PTDC/SAU-ORG/113542/2009] Funding Source: FCT
FX This work was supported by grants from the Portuguese Foundation for
   Science and Technology (FCT): PTDC/SAU-ORG/113542/2009 and
   Pest-C/SAU/UI3282/2011. Conflict of interest statement: The authors
   declare that they have no conflicts of interest associated with this
   work.
CR Agardh CD, 1997, J DIABETES COMPLICAT, V11, P158, DOI 10.1016/S1056-8727(96)00049-9
   Aggarwal Dimple, 2005, BMC Cardiovasc Disord, V5, P30, DOI 10.1186/1471-2261-5-30
   BAYNES JW, 1991, DIABETES, V40, P405, DOI 10.2337/diabetes.40.4.405
   Bellosta S, 2000, DIABETES CARE, V23, pB72
   Bierhaus A, 2001, DIABETES, V50, P2792, DOI 10.2337/diabetes.50.12.2792
   Costa A, 2003, DIABETIC MED, V20, P743, DOI 10.1046/j.1464-5491.2003.00993.x
   Davignon J, 2004, CORONARY ARTERY DIS, V15, P251, DOI 10.1097/01.mca.0000131573.31966.34
   ENGERMAN RL, 1989, DIABETES, V38, P1203, DOI 10.2337/diabetes.38.10.1203
   Fernandes R, 2004, MOL VIS, V10, P618
   Fernandes R, 2004, J BIOL CHEM, V279, P27219, DOI 10.1074/jbc.M400446200
   Fernandes R, 2006, MOL VIS, V12, P1526
   Fernandes R, 2011, AM J PHYSIOL-CELL PH, V300, pC927, DOI 10.1152/ajpcell.00140.2010
   Gonçalves A, 2012, DIABETES OBES METAB, V14, P454, DOI 10.1111/j.1463-1326.2011.01548.x
   GORDON B, 1991, AM J OPHTHALMOL, V112, P385, DOI 10.1016/S0002-9394(14)76244-0
   GOTO Y, 1976, TOHOKU J EXP MED, V119, P85, DOI 10.1620/tjem.119.85
   Goto Y, 1988, Adv Exp Med Biol, V246, P29
   GRUNE T, 1995, J BIOL CHEM, V270, P2344, DOI 10.1074/jbc.270.5.2344
   Grune T, 1998, J BIOL CHEM, V273, P10857, DOI 10.1074/jbc.273.18.10857
   Güçlü F, 2004, BIOMED PHARMACOTHER, V58, P614, DOI 10.1016/j.biopha.2004.09.005
   Gupta A, 2004, AM J OPHTHALMOL, V137, P675, DOI 10.1016/j.ajo.2003.11.017
   Hammes HP, 2002, DIABETES, V51, P3107, DOI 10.2337/diabetes.51.10.3107
   JENNINGS PE, 1991, DIABETIC MED, V8, P860, DOI 10.1111/j.1464-5491.1991.tb02125.x
   Kowluru RA, 2001, DIABETES, V50, P1938, DOI 10.2337/diabetes.50.8.1938
   Kowluru RA, 2000, CURR EYE RES, V21, P814, DOI 10.1076/ceyr.21.4.814.5545
   Leal EC, 2007, INVEST OPHTH VIS SCI, V48, P5257, DOI 10.1167/iovs.07-0112
   Miyahara S, 2004, AM J PATHOL, V164, P1697, DOI 10.1016/S0002-9440(10)63728-5
   Miyamoto K, 1996, INVEST OPHTH VIS SCI, V37, P898
   Paniagua JA, 2002, DIABETES, V51, P2596, DOI 10.2337/diabetes.51.8.2596
   Perticone F, 2000, ATHEROSCLEROSIS, V152, P511, DOI 10.1016/S0021-9150(00)00370-1
   Portero-Otín M, 1999, DIABETES, V48, P2215, DOI 10.2337/diabetes.48.11.2215
   PORTHA B, 1991, DIABETES, V40, P486, DOI 10.2337/diabetes.40.4.486
   Queisser MA, 2010, DIABETES, V59, P670, DOI 10.2337/db08-1565
   Rains JL, 2011, FREE RADICAL BIO MED, V50, P567, DOI 10.1016/j.freeradbiomed.2010.12.006
   Reinheckel T, 1998, BIOCHEM J, V335, P637, DOI 10.1042/bj3350637
   SASAKI T, 1984, J BIOL CHEM, V259, P2489
   Satoh K, 2005, BIOL PHARM BULL, V28, P2092, DOI 10.1248/bpb.28.2092
   Seica Raquel M, 2004, Acta Med Port, V17, P42
   Sena CM, 2007, DIABETES METAB, V33, P296, DOI 10.1016/j.diabet.2007.03.002
   Sena CM, 2014, PHYSIOL RES, V63, P189, DOI 10.33549/physiolres.932554
   Sena CM, 2011, BRIT J PHARMACOL, V163, P424, DOI 10.1111/j.1476-5381.2011.01230.x
   Shang F, 2011, FREE RADICAL BIO MED, V51, P5, DOI 10.1016/j.freeradbiomed.2011.03.031
   Simsek S, 2012, DIABETIC MED, V29, P628, DOI 10.1111/j.1464-5491.2011.03553.x
   Sone H, 1997, DIABETOLOGIA, V40, P726, DOI 10.1007/s001250050740
   Sonmez A, 2003, ENDOCRINE, V22, P151, DOI 10.1385/ENDO:22:2:151
   Stüve O, 2003, CURR OPIN NEUROL, V16, P393, DOI 10.1097/01.wco.0000073942.19076.d1
   Wang XN, 2006, ENDOCRINOLOGY, V147, P4160, DOI 10.1210/en.2006-0251
   Watts GF, 2003, DIABETES, V52, P803, DOI 10.2337/diabetes.52.3.803
   Xu J, 2007, CIRCULATION, V116, P944, DOI 10.1161/CIRCULATIONAHA.106.684795
   Zhang XP, 2002, J NEUROCHEM, V82, P181, DOI 10.1046/j.1471-4159.2002.00975.x
NR 49
TC 13
Z9 16
U1 0
U2 15
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD DEC
PY 2014
VL 92
IS 12
BP 1037
EP 1043
DI 10.1139/cjpp-2014-0212
PG 7
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA AU4DG
UT WOS:000345558600008
PM 25404034
DA 2025-06-11
ER

PT J
AU Metoki, H
AF Metoki, Hirohito
TI The Significance of Observing the Risk of Non-communicable Diseases
   after Large-scale Disasters and Communicable Disease Epidemics
SO JMA JOURNAL
LA English
DT Review
DE Non -communicable diseases; COVID-19; disasters; cohort study; biobank
ID GREAT EAST JAPAN; EARTHQUAKE
AB Non-communicable diseases (NCDs) are a global challenge, accounting for 71% of all deaths worldwide. The spread of coronavirus disease 2019 (COVID-19) and past huge disasters have affected the prevention and treatment of NCDs and require urgent action. In this narrative review, I will discuss several reports on the risk of NCDs during past disasters and propose possible future directions. Hypertension, the most common NCD, carries a high risk of death due to cerebrovascular, renal, and other complications. Effective use of information and communication technology-based telemedicine is necessary to manage the risk of cardiovascular diseases during disasters and pandemics. We observed the cumulative incidence of metabolic syndrome in subjects from tsunami-affected areas. We found that moving into prefabricated temporary housing was a risk factor for a higher incidence of metabolic syndrome in elderly females. Our follow-up of 1,009 subjects showed a slight, but significant, increase in HbA1c values after a state of emergency was introduced, even though the lockdown was not as stringent as in other countries. In a study elucidating the prevalence of wheezing and eczema symptoms and the associated factors after the Great East Japan Earthquake, psychological effects, such as depression and self-reported posttraumatic stress disorder, were observed, particularly in people with allergic diseases. In recent years, new birth cohort studies have been initiated to complement the studies designed to collect information across multiple generations, such as the Lifelines study in the Netherlands and the Avon Longitudinal Study of Parents and Children (ALSPAC) study in the UK. It is desirable to assess the effects of COVID-19 to complement the existing cohort studies in Japan as well.
C1 [Metoki, Hirohito] Tohoku Med & Pharmaceut Univ, Div Publ Hlth Hyg & Epidemiol, Sendai, Japan.
   [Metoki, Hirohito] Tohoku Univ, Dept Prevent Med cine & Epidemiol, Tohoku Med Megabank Org, Sendai, Japan.
C3 Tohoku Medical & Pharmaceutical University; Tohoku University
RP Metoki, H (corresponding author), Tohoku Med & Pharmaceut Univ, Div Publ Hlth Hyg & Epidemiol, Sendai, Japan.; Metoki, H (corresponding author), Tohoku Univ, Dept Prevent Med cine & Epidemiol, Tohoku Med Megabank Org, Sendai, Japan.
EM hmetoki@tohoku-mpu.ac.jp
RI Metoki, Hirohito/B-3376-2009
FU Medical Research Encouragement Prize of The Japan Medical Association
FX This work was supported by Medical Research Encouragement Prize of The
   Japan Medical Association
CR Adams LM, 2021, J AGING HEALTH, V33, P458, DOI 10.1177/0898264321991314
   Aryal S, 2020, ASIAN J PSYCHIATR, V54, DOI 10.1016/j.ajp.2020.102281
   Asai Keigo, 2021, J Affect Disord Rep, V4, P100104, DOI 10.1016/j.jadr.2021.100104
   Dzygalo Katarzyna, 2020, Pediatr Endocrinol Diabetes Metab, V26, P167, DOI 10.5114/pedm.2020.101003
   Gonzalez-Diaz SN, 2021, WORLD ALLERGY ORGAN, V14, DOI 10.1016/j.waojou.2021.100510
   Hatakeyama K, 2021, SCI TOTAL ENVIRON, V768, DOI 10.1016/j.scitotenv.2021.145176
   Hills S, 2021, BMC PUBLIC HEALTH, V21, DOI 10.1186/s12889-021-10379-7
   Holland KM, 2021, JAMA PSYCHIAT, V78, P372, DOI 10.1001/jamapsychiatry.2020.4402
   Ikeda N, 2011, LANCET, V378, P1094, DOI 10.1016/S0140-6736(11)61055-6
   Ishikuro M, 2023, J EPIDEMIOL, V33, P127, DOI 10.2188/jea.JE20210052
   Ishikuro M, 2017, BMJ GLOB HEALTH, V2, DOI 10.1136/bmjgh-2016-000127
   Japan Agency for Medical Research and Development, Building a large-scale genome cohort with 366,000 people-Collaboration with 6 domestic research institutes for early realization of personalized medicine and prevention of personalizationContribution to early realization of next-generation medical care by mutual utilization of data
   Jungari S, 2020, PUBLIC HEALTH, V185, P97, DOI 10.1016/j.puhe.2020.05.062
   Kachi Y, 2021, J OCCUP HEALTH, V63, DOI 10.1002/1348-9585.12196
   Kotlar B, 2021, REPROD HEALTH, V18, DOI 10.1186/s12978-021-01070-6
   Kwong ASF, 2021, BRIT J PSYCHIAT, V218, P334, DOI 10.1192/bjp.2020.242
   Leite JS, 2021, CIENC SAUDE COLETIVA, V26, P987, DOI 10.1590/1413-81232021263.39232020
   Marçal IR, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.584642
   Mc Intyre K, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2020-044474
   Mills KT, 2021, J AM HEART ASSOC, V10, DOI 10.1161/JAHA.120.018510
   Miyashita M, 2015, TOHOKU J EXP MED, V237, P297, DOI 10.1620/tjem.237.297
   Narita K, 2021, J CLIN HYPERTENS, V23, P575, DOI 10.1111/jch.14192
   Nishigori H, 2014, ARCH WOMEN MENT HLTH, V17, P579, DOI 10.1007/s00737-014-0459-y
   Nomura K, 2021, ENVIRON HEALTH PREV, V26, DOI 10.1186/s12199-021-00953-1
   Omama S, 2013, STROKE, V44, P1518, DOI 10.1161/STROKEAHA.111.000442
   Biermann CR, 2021, INT J GYNECOL OBSTET, V153, P549, DOI 10.1002/ijgo.13676
   Ruissen MM, 2021, BMJ OPEN DIAB RES CA, V9, DOI 10.1136/bmjdrc-2020-002035
   Saccone G, 2020, AM J OBSTET GYNECOL, V223, P293, DOI 10.1016/j.ajog.2020.05.003
   Satoh M, 2011, HYPERTENSION, V58, pE193, DOI 10.1161/HYPERTENSIONAHA.111.184077
   Suga T, 2021, SEX REPROD HLTH MATT, V29, DOI 10.1080/26410397.2021.1874601
   Takahashi Shuko, 2020, Metabol Open, V7, P100042, DOI 10.1016/j.metop.2020.100042
   Tanji Y, 2021, DIABETES RES CLIN PR, V176, DOI 10.1016/j.diabres.2021.108840
   Tanoue K, 2021, J INTERPERS VIOLENCE, V36, P10013, DOI 10.1177/0886260519881517
   Tsuboya T, 2017, ENVIRON HEALTH PREV, V22, DOI 10.1186/s12199-017-0615-x
   Walker KF, 2020, BJOG-INT J OBSTET GY, V127, P1324, DOI 10.1111/1471-0528.16362
   Woodward M, 2021, J EPIDEMIOL COMMUN H, V75, P1050, DOI 10.1136/jech-2020-215810
   World Health Oorganization, COVID-19 significantly impacts health services for non-communicable diseases
   World Health Organization, Noncommunicable diseases-SEARO 2020
   Wu YT, 2020, AM J OBSTET GYNECOL, V223, DOI 10.1016/j.ajog.2020.05.009
   Zhu YJ, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2020-048020
NR 40
TC 4
Z9 4
U1 0
U2 1
PU JAPAN MEDICAL ASSOC-JAPANESE ASSOC MEDICAL SCIENCES
PI TOKYO
PA 2-28-16 HONKOMAGOME, BUNKYO-KU, TOKYO, 113-8621, JAPAN
SN 2433-328X
EI 2433-3298
J9 JMA J
JI JMA J.
PD OCT 15
PY 2021
VL 4
IS 4
BP 305
EP 310
DI 10.31662/jmaj.2021-0126
PG 6
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA FY9E3
UT WOS:001149524700007
PM 34796284
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jalali, MM
   Dalili, S
   Koohmanaee, S
   Rad, S
AF Jalali, Mir Mohammad
   Dalili, Setila
   Koohmanaee, Shahin
   Rad, Samira
TI The Role of Metabolic Syndrome Components in Sensorineural Hearing Loss
   in Adolescents: A Case-Control Study
SO INTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY
LA English
DT Article
DE sensorineural hearing loss; metabolic syndrome; triglycerides;
   adolescent
ID NUTRITION EXAMINATION SURVEY; PLASMA ADIPONECTIN LEVELS; TYPE-2
   DIABETES-MELLITUS; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; IRANIAN
   CHILDREN; NATIONAL-HEALTH; DYSFUNCTION; PREVALENCE; STATEMENT
AB Introduction Metabolic syndrome (MetS) and its associated components were reported as a possible cause of inner ear dysfunction. However, research about the influence of cardiovascular risk factors on hearing thresholds are conducted mainly in adult patients. Objective The aim of the present study was to investigate auditory function in adolescents with MetS compared with healthy controls.
   Methods One hundred adolescents with metabolic syndrome and 200 sex- and agematched controls were recruited from a university pediatric endocrine clinic from May 2018 to July 2020. Hearing loss was defined as hearing level >= 15 dB at speech frequency (SFHL) or high frequency (HFHL) in one or both ears. A multivariable conditional logistic regression analysis examined the correlation between MetS components and several important demographic characteristics, and hearing loss.
   Results A total of 165 (55.0%) boys and 135 (45.0%) girls participated in this study. The rates of SFHL and HFHL in adolescents withMetS were 32.0% and 51.0%, respectively. Those values for controls were 5.0% and 15.5%, respectively. The regression analysis showed high triglycerides as a significant predictor for SFHL (odds ratio 10.87; 95% confidence interval: 1.98, 59.74). Neither predictor of interest was significant for HFHL.
   Conclusion Hypertriglyceridemia may be an important factor in the pathogenesis of SFHL. However, the strength of the association was not significant with a wide confidence interval. Also, we were unable to find an association between predictors and HFHL with the current sample size. Larger and prospective studies are recommended.
C1 [Jalali, Mir Mohammad] Guilan Univ Med Sci, Otorhinolaryngol Res Ctr, Sch Med, Dept Otolaryngol, Rasht, Iran.
   [Dalili, Setila; Koohmanaee, Shahin; Rad, Samira] Guilan Univ Med Sci, Pediat Res Ctr, Sch Med, Dept Pediat Endocrinol & Metab, Rasht, Iran.
   [Jalali, Mir Mohammad] Guilan Univ Med Sci, Amiralmomenin Hosp, Dept Otolaryngol, Rasht, Iran.
C3 Guilan University of Medical Sciences; Guilan University of Medical
   Sciences; Guilan University of Medical Sciences
RP Jalali, MM (corresponding author), Guilan Univ Med Sci, Amiralmomenin Hosp, Dept Otolaryngol, Rasht, Iran.
EM mmjalali@gmail.com
RI koohmanaee, shahin/K-7200-2017; Jalali, mir/G-3640-2017
OI Rad, Samira/0000-0003-4981-4454
CR Ahmadi N, 2020, IRAN J PUBLIC HEALTH, V49, P360, DOI 10.18502/ijph.v49i2.3106
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Anbari S, 2010, INT J PEDIATR OTORHI, V74, P32, DOI 10.1016/j.ijporl.2009.10.003
   .cdc.gov, 2020, CTR DIS CONTROL PREV
   Dhanda N, 2017, INT J OBESITY, V41, P1066, DOI 10.1038/ijo.2017.32
   Di Nardo W, 1998, DIABETES CARE, V21, P1317, DOI 10.2337/diacare.21.8.1317
   DiLeo MAS, 1997, DIABETES CARE, V20, P824, DOI 10.2337/diacare.20.5.824
   Elangovan Saravanan, 2019, Seminars in Hearing, V40, P292, DOI 10.1055/s-0039-1697033
   Esparza CM, 2007, CLIN OTOLARYNGOL, V32, P173, DOI 10.1111/j.1365-2273.2007.01442.x
   Friend A, 2013, METAB SYNDR RELAT D, V11, P71, DOI 10.1089/met.2012.0122
   Fukushima H, 2005, OTOLARYNG HEAD NECK, V133, P100, DOI 10.1016/j.otohns.2005.02.004
   Fukushima H, 2006, ARCH OTOLARYNGOL, V132, P934, DOI 10.1001/archotol.132.9.934
   Heshmat R, 2018, J CARDIOVASC THORAC, V10, P214, DOI 10.15171/jcvtr.2018.37
   Huang KC, 2004, OBES RES, V12, P119, DOI 10.1038/oby.2004.16
   Jung SY, 2018, JAMA OTOLARYNGOL, V144, P308, DOI 10.1001/jamaoto.2017.3144
   Kariya S, 2010, ACTA MED OKAYAMA, V64, P375
   Kelishadi R, 2016, J RES MED SCI, V21, DOI 10.4103/1735-1995.192506
   Kelishadi R, 2016, J PEDIATR ENDOCR MET, V29, P1069, DOI 10.1515/jpem-2016-0041
   Kiliç K, 2018, TURK ARCH OTORHINOL, V56, P160, DOI 10.5152/tao.2018.3426
   Kim H, 2019, LARYNGOSCOPE, V129, P470, DOI 10.1002/lary.27478
   Kocyigit M, 2020, INT ARCH OTORHINOLAR, V24, pE198, DOI 10.1055/s-0039-1698775
   Kohlberg GD, 2018, OTOL NEUROTOL, V39, P1102, DOI 10.1097/MAO.0000000000001956
   Lalwani AK, 2013, LARYNGOSCOPE, V123, P3178, DOI 10.1002/lary.24244
   Lin SW, 2012, OTOL NEUROTOL, V33, P1482, DOI 10.1097/MAO.0b013e318271397a
   Loprinzi PD, 2017, AM J AUDIOL, V26, P163, DOI 10.1044/2017_AJA-16-0057
   Yubero-Serrano EM, 2013, EXP MOL MED, V45, DOI 10.1038/emm.2013.53
   Martin ASG, 2006, AM J CLIN NUTR, V83, p461S, DOI 10.1093/ajcn/83.2.461s
   Moore DR, 2020, EAR HEARING, V41, P720, DOI 10.1097/AUD.0000000000000802
   Niskar AS, 2001, PEDIATRICS, V108, P40, DOI 10.1542/peds.108.1.40
   Ouchi N, 2000, CIRCULATION, V102, P1296, DOI 10.1161/01.CIR.102.11.1296
   Pou KM, 2007, CIRCULATION, V116, P1234, DOI 10.1161/CIRCULATIONAHA.107.710509
   Przewozny T, 2016, J HYPERTENS, V34, P736, DOI 10.1097/HJH.0000000000000803
   Reilly JJ, 2003, ARCH DIS CHILD, V88, P748, DOI 10.1136/adc.88.9.748
   Sánchez-Rodríguez MA, 2010, ANN NUTR METAB, V56, P302, DOI 10.1159/000309601
   Satar B, 2001, OTOL NEUROTOL, V22, P786, DOI 10.1097/00129492-200111000-00012
   Scinicariello F., 2019, SCI REP-UK, V9, P1
   Suzuki K, 2000, LARYNGOSCOPE, V110, P1736, DOI 10.1097/00005537-200010000-00033
   Tanigawa T, 2014, CELL DEATH DIS, V5, DOI 10.1038/cddis.2014.140
   Teng ZP, 2017, LARYNGOSCOPE, V127, P1689, DOI 10.1002/lary.26346
   Torre P, 2005, J SPEECH LANG HEAR R, V48, P473, DOI 10.1044/1092-4388(2005/032)
   von Elm E, 2014, INT J SURG, V12, P1495, DOI 10.1016/j.ijsu.2014.07.013
   Wang J, 2018, INT J OBESITY, V42, P1771, DOI 10.1038/s41366-018-0170-6
   Weihe P, 2019, CURR OBES REP, V8, P472, DOI 10.1007/s13679-019-00357-x
   Wu CC, 2015, NEUROBIOL AGING, V36, P2085, DOI 10.1016/j.neurobiolaging.2015.02.030
   Yang WS, 2002, OBES RES, V10, P1104, DOI 10.1038/oby.2002.150
   Zhou YL, 2019, AM J OTOLARYNG, V40, P573, DOI 10.1016/j.amjoto.2019.05.011
   Zimmet P, 2007, PEDIATR DIABETES, V8, P299, DOI 10.1111/j.1399-5448.2007.00271.x
NR 47
TC 2
Z9 2
U1 0
U2 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 1809-9777
EI 1809-4864
J9 INT ARCH OTORHINOLAR
JI Int. Arch. Otorhinolaryngol.
PD JUL
PY 2023
VL 27
IS 03
BP 393
EP 399
DI 10.1055/s-0041-1742241
PG 7
WC Otorhinolaryngology
WE Emerging Sources Citation Index (ESCI)
SC Otorhinolaryngology
GA O3OR5
UT WOS:001042949400004
PM 37564469
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhao, YT
   Sedighi, R
   Wang, P
   Chen, HD
   Zhu, YD
   Sang, SM
AF Zhao, Yantao
   Sedighi, Rashin
   Wang, Pei
   Chen, Huadong
   Zhu, Yingdong
   Sang, Shengmin
TI Carnosic Acid as a Major Bioactive Component in Rosemary Extract
   Ameliorates High-Fat-Diet-Induced Obesity and Metabolic Syndrome in Mice
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE rosemary; carnosic acid; obesity; metabolic syndrome; high-fat diet;
   oxidative stress
ID ROSMARINUS-OFFICINALIS L.; GLYCATION END-PRODUCTS; LIMITS WEIGHT-GAIN;
   HEPATIC STEATOSIS; PROTEIN GLYCATION; LIVER; DISEASE; PLANT
AB In this study, we investigated the preventive effects of carnosic acid (CA) as a major bioactive component in rosemary extract (RE) on high-fat-diet-induced obesity and metabolic syndrome in mice. The mice were given a low-fat diet, a high-fat diet or a high-fat diet supplemented with either 0.14% or 0.28% (w/w) CA-enriched RE (containing 80% CA, REAM and RE#1H), or 0.5% (w/w) RE (containing 45% CA, RE#2), for a period of 16 weeks. There was the same CA content in the RE#1H and RE#2 diets and half of this amount in the RE#1L diet. The dietary RE supplementation significantly reduced body weight gain, percent of fat, plasma ALT, AST, glucose, insulin levels, liver weight, liver triglyceride, and free fatty acid levels in comparison with the mice fed with a HF diet without RE treatment. RE administration also decreased the levels of plasma and liver malondialdehyde, advanced glycation end products (AGEs), and the liver expression of receptor for AGE (RAGE) in comparison with those for mice of the HF group. Histological analyses of liver samples showed decreased lipid accumulation in hepatocytes in mice administrated with RE in comparison with that of HF-diet-fed mice. Meanwhile, RE administration enhanced fecal lipid excretion to inhibit lipid absorption and increased the liver GSH/GSSG ratio to perform antioxidant activity compared with HF group. Our results demonstrate that rosemary is a promising dietary agent to reduce the risk of obesity and metabolic syndrome.
C1 [Zhao, Yantao; Sedighi, Rashin; Wang, Pei; Chen, Huadong; Zhu, Yingdong; Sang, Shengmin] North Carolina Agr & Tech State Univ, Ctr Excellence Postharvest Technol, Kannapolis, NC 28081 USA.
C3 University of North Carolina; North Carolina A&T State University
RP Sang, SM (corresponding author), North Carolina Agr & Tech State Univ, Ctr Excellence Postharvest Technol, North Carolina Res Campus,500 Laureate Way, Kannapolis, NC 28081 USA.
EM ssang@ncat.edu
RI Sang, Shengmin/AFK-9982-2022; Chen, Huadong/H-2272-2013
OI Zhao, Yantao/0000-0003-0722-195X
FU USDA National Institute of Food and Agriculture [2011-38821-31131]
FX This study was supported by funding from the USDA National Institute of
   Food and Agriculture (Grant No. 2011-38821-31131) to S.S.
CR Anders S, 2015, FRONT ENDOCRINOL, V6, DOI 10.3389/fendo.2015.00033
   [Anonymous], 2008, EFSA J
   Bose M, 2008, J NUTR, V138, P1677, DOI 10.1093/jn/138.9.1677
   Cai ZJ, 1999, WHO TECH REP SER, V887, P1
   Calabrese V, 2000, INT J TISSUE REACT, V22, P5
   Chen HD, 2012, DRUG METAB DISPOS, V40, P742, DOI 10.1124/dmd.111.043331
   Cuvelier ME, 1996, J AM OIL CHEM SOC, V73, P645, DOI 10.1007/BF02518121
   Dearlove RP, 2008, J MED FOOD, V11, P275, DOI 10.1089/jmf.2007.536
   Etter S. C., 2004, Journal of Herbs, Spices & Medicinal Plants, V11, P121, DOI 10.1300/J044v11n01_05
   Fabricatore A.N., 2003, CLIN DIABETES, V21, P67, DOI DOI 10.2337/DIACLIN.21.2.67
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   Fraulob JC, 2010, J CLIN BIOCHEM NUTR, V46, P212, DOI 10.3164/jcbn.09-83
   Harach T, 2010, PLANTA MED, V76, P566, DOI 10.1055/s-0029-1240612
   Henle T, 1999, NEPHROL DIAL TRANSPL, V14, P1968, DOI 10.1093/ndt/14.8.1968
   Ho CT, 2000, BIOFACTORS, V13, P161, DOI 10.1002/biof.5520130126
   Hsieh CL, 2007, J AGR FOOD CHEM, V55, P2884, DOI 10.1021/jf0631833
   Ibarra A, 2011, BRIT J NUTR, V106, P1182, DOI 10.1017/S0007114511001620
   Kim HY, 2003, J AGR FOOD CHEM, V51, P1586, DOI 10.1021/jf020850t
   Li SY, 2005, DIABETES OBES METAB, V7, P448, DOI 10.1111/j.1463-1326.2004.00387.x
   Lu J, 2014, FREE RADICAL BIO MED, V66, P75, DOI 10.1016/j.freeradbiomed.2013.07.036
   Lu SC, 2013, BBA-GEN SUBJECTS, V1830, P3143, DOI 10.1016/j.bbagen.2012.09.008
   Milagro FI, 2006, OBESITY, V14, P1118, DOI 10.1038/oby.2006.128
   Munch G, 1997, EUR J CLIN CHEM CLIN, V35, P669
   NAKAYAMA H, 1993, DIABETES, V42, P345, DOI 10.2337/diabetes.42.2.345
   Panda H., 2009, AROMATIC PLANTS CULT, P22
   Park MY, 2013, NUTR RES PRACT, V7, P294, DOI 10.4162/nrp.2013.7.4.294
   Raposeiras-Roubín S, 2010, EUR J HEART FAIL, V12, P1092, DOI 10.1093/eurjhf/hfq117
   Razborsek MI, 2007, ACTA CHIM SLOV, V54, P60
   Reagan-Shaw S, 2008, FASEB J, V22, P659, DOI 10.1096/fj.07-9574LSF
   Riccardi G, 2005, CURR OPIN CLIN NUTR, V8, P630, DOI 10.1097/01.mco.0000171126.98783.0c
   Robert Aeschbach V, 1993, U.S. Patent, Patent No. [5,256,700, 5256700]
   Roblin L, 2007, APPL PHYSIOL NUTR ME, V32, P635, DOI 10.1139/H07-046
   Vaquero MR, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039773
   Romo-Vaquero M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094687
   Tu Z, 2013, J AGR FOOD CHEM, V61, P2803, DOI 10.1021/jf400298c
   Wang T, 2012, J GASTROENTEROL, V47, P805, DOI 10.1007/s00535-012-0546-7
   Wang T, 2011, HEPATOL RES, V41, P87, DOI 10.1111/j.1872-034X.2010.00747.x
   Whitmore Catherine, 2010, Br J Nurs, V19, P882
   Yamabe N, 2009, BIOL PHARM BULL, V32, P657, DOI 10.1248/bpb.32.657
NR 39
TC 94
Z9 98
U1 0
U2 49
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD MAY 20
PY 2015
VL 63
IS 19
BP 4843
EP 4852
DI 10.1021/acs.jafc.5b01246
PG 10
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA CJ0GS
UT WOS:000355154400018
PM 25929334
DA 2025-06-11
ER

PT J
AU Lteif, A
   Mather, K
AF Lteif, A
   Mather, K
TI Insulin resistance, metabolic syndrome and vascular diseases: Update on
   mechanistic linkages
SO CANADIAN JOURNAL OF CARDIOLOGY
LA English
DT Article; Proceedings Paper
CT Advances in Vascular Biology Symposium
CY AUG 14-17, 2003
CL Vancouver, CANADA
SP Pfizer Canada
DE asymmetric dimethylarginine; endothelin; insulin resistance; metabolic
   syndrome; nitric oxide; risk factors; tetrahydrobiopterin
ID C-REACTIVE PROTEIN; NITRIC-OXIDE SYNTHASE; PLASMINOGEN-ACTIVATOR
   INHIBITOR; CORONARY-HEART-DISEASE; TUMOR-NECROSIS-FACTOR;
   ENDOTHELIUM-DEPENDENT VASODILATION; TYPE-2 DIABETES-MELLITUS;
   POLYCYSTIC-OVARY-SYNDROME; CARDIOVASCULAR RISK-FACTORS;
   FRUCTOSE-HYPERTENSIVE RATS
AB Epidemiological associations are now well-established between insulin resistance, the metabolic syndrome and worsened cardiovascular outcomes. A direct role of insulin in vascular biology is also now broadly recognized. Specifically, insulin can directly stimulate the action of nitric oxide synthase, an effect that can be demonstrated both in vitro and in vivo. Insulin resistance, whether present endogenously or produced experimentally through exposure to fatty acids, glucosamine or turnout necrosis factor alpha, is associated with impaired endothelium-dependent vasodilation and, specifically, with impaired insulin-stimulated vasodilation. A number of potential molecular explanations for these observations are being pursued, with evidence to support a number of concurrent pathogenic mechanisms. These include insulin resistance-associated reductions in nitric oxide availability due to increases in oxidative stress (not requiring the presence of hyperglycemia), reduced availability of tetrahydrobiopterin and excess levels of asymmetrical dimethylarginine. A strong body of evidence also supports an excess of the vasoconstrictor endothelin, which may result directly from hyperinsulinemia and/or indirectly due to a loss of the suppressive effects of nitric oxide on endothelin production and action. The current leading edge of investigations into the association between insulin-resistant states and vascular dysfunction involves the expanding repertoire of adipocyte-derived hormones. Of these, particular interest has been focused on adiponectin, which has both vascular and metabolic actions, and may contribute importantly to the connection between metabolism and vascular function. Progress along these novel lines of investigation will continue to expand the understanding of the mechanisms linking insulin resistance, the metabolic syndrome and vascular disease.
C1 Indiana Univ, Sch Med, Indianapolis, IN 46204 USA.
C3 Indiana University System; Indiana University Indianapolis
RP 975 W Walnut St,IB424, Indianapolis, IN 46202 USA.
EM kmather@iupui.edu
RI Mather, Kieren/ABE-4117-2020
CR Abbink EJ, 2002, DIABETIC MED, V19, P136, DOI 10.1046/j.1464-5491.2002.00663.x
   Abe H, 1998, J CLIN INVEST, V101, P1784, DOI 10.1172/JCI1594
   Al Suwaidi J, 2000, CIRCULATION, V101, P948, DOI 10.1161/01.CIR.101.9.948
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Asagami T, 2002, METABOLISM, V51, P843, DOI 10.1053/meta.2002.33349
   Bagi Z, 2003, J VASC RES, V40, P47, DOI 10.1159/000068938
   Balletshofer BM, 2000, CIRCULATION, V101, P1780, DOI 10.1161/01.CIR.101.15.1780
   Bao WH, 1996, CIRCULATION, V93, P54, DOI 10.1161/01.CIR.93.1.54
   Baron AD, 1995, J CLIN INVEST, V96, P2792, DOI 10.1172/JCI118349
   Böger RH, 2000, SEMIN THROMB HEMOST, V26, P539, DOI 10.1055/s-2000-13210
   BOULANGER C, 1990, J CLIN INVEST, V85, P587, DOI 10.1172/JCI114477
   Bruning JC, 1998, MOL CELL, V2, P559, DOI 10.1016/S1097-2765(00)80155-0
   Calabró P, 2003, CIRCULATION, V108, P1930, DOI 10.1161/01.CIR.0000096055.62724.C5
   Carmassi F, 1999, AM J MED, V107, P344, DOI 10.1016/S0002-9343(99)00240-5
   Catalano M, 1997, Vasc Med, V2, P302
   Cavarape A, 2001, J ENDOCRINOL INVEST, V24, P838, DOI 10.1007/BF03343940
   Ceolotto G, 1999, DIABETES, V48, P1316, DOI 10.2337/diabetes.48.6.1316
   Chambers JC, 2001, CIRCULATION, V104, P145, DOI 10.1161/01.CIR.104.2.145
   Chan NN, 2002, DIABETOLOGIA, V45, P1609, DOI 10.1007/s00125-002-0975-6
   Charles MA, 1998, DIABETES CARE, V21, P1967, DOI 10.2337/diacare.21.11.1967
   Chen Y, 2002, NUTR METAB CARDIOVAS, V12, P325
   Chen YB, 2000, ARTERIOSCL THROM VAS, V20, P2696, DOI 10.1161/01.ATV.20.12.2696
   Chu NV, 2002, DIABETES CARE, V25, P542, DOI 10.2337/diacare.25.3.542
   Clerk LH, 2002, DIABETES, V51, P1138, DOI 10.2337/diabetes.51.4.1138
   Dagenais GR, 2001, CIRCULATION, V104, P522, DOI 10.1161/hc3001.093502
   Danesh J, 1998, JAMA-J AM MED ASSOC, V279, P1477, DOI 10.1001/jama.279.18.1477
   de Kreutzenberg SV, 2000, J CLIN ENDOCR METAB, V85, P793, DOI 10.1210/jc.85.2.793
   DeMeyer GRY, 1997, PROG CARDIOVASC DIS, V39, P325, DOI 10.1016/S0033-0620(97)80031-X
   Despres JP, 1996, NEW ENGL J MED, V334, P952, DOI 10.1056/NEJM199604113341504
   Duplain H, 2001, CIRCULATION, V104, P342, DOI 10.1161/01.CIR.104.3.342
   Ebeling P, 1999, DIABETOLOGIA, V42, P1433, DOI 10.1007/s001250051315
   Egan BM, 1999, PROSTAG LEUKOTR ESS, V60, P411, DOI 10.1016/S0952-3278(99)80022-2
   Eid HM, 2003, ATHEROSCLEROSIS, V166, P279, DOI 10.1016/S0021-9150(02)00206-X
   El Midaoui A, 2002, HYPERTENSION, V39, P303, DOI 10.1161/hy0202.104345
   Eliasson M, 1997, DIABETES CARE, V20, P1252, DOI 10.2337/diacare.20.8.1252
   Esberg LB, 2003, DIABETOLOGIA, V46, P1419, DOI 10.1007/s00125-003-1183-8
   Esposito K, 2003, JAMA-J AM MED ASSOC, V289, P1799, DOI 10.1001/jama.289.14.1799
   Evans T, 2000, DIABETES, V49, P662, DOI 10.2337/diabetes.49.4.662
   Facchini F, 1996, AM J CLIN NUTR, V63, P946, DOI 10.1093/ajcn/63.6.946
   Facchini FS, 2000, AM J CLIN NUTR, V72, P776
   Faure P, 1999, DIABETES, V48, P353, DOI 10.2337/diabetes.48.2.353
   FERRI C, 1995, J CLIN ENDOCR METAB, V80, P829, DOI 10.1210/jc.80.3.829
   FERRI C, 1995, DIABETES, V44, P431, DOI 10.2337/diabetes.44.4.431
   Festa A, 1999, ARTERIOSCL THROM VAS, V19, P562, DOI 10.1161/01.ATV.19.3.562
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Folsom AR, 2002, AM HEART J, V144, P233, DOI 10.1067/mhj.2002.124054
   FONTBONNE AM, 1991, DIABETES CARE, V14, P461, DOI 10.2337/diacare.14.6.461
   Gabriely I, 2002, ATHEROSCLEROSIS, V160, P115, DOI 10.1016/S0021-9150(01)00574-3
   Garg R, 2000, HYPERTENSION, V36, P430, DOI 10.1161/01.HYP.36.3.430
   Glueck CJ, 2000, FERTIL STERIL, V74, P394, DOI 10.1016/S0015-0282(00)00630-0
   Glueck CJ, 2001, METABOLISM, V50, P856, DOI 10.1053/meta.2001.24192
   GOLIGORSKY MS, 1994, J CELL PHYSIOL, V158, P485, DOI 10.1002/jcp.1041580313
   Gottschling-Zeller H, 2000, DIABETOLOGIA, V43, P377, DOI 10.1007/s001250050057
   Grant PJ, 1996, DIABETES CARE, V19, P64, DOI 10.2337/diacare.19.1.64
   Gray RP, 1997, ATHEROSCLEROSIS, V130, P171, DOI 10.1016/S0021-9150(96)06070-4
   Grenett HE, 1999, THROMB HAEMOSTASIS, V82, P1504
   Hadigan C, 2001, J CLIN ENDOCR METAB, V86, P939, DOI 10.1210/jc.86.2.939
   Haffner SM, 1999, DIABETES CARE, V22, P562, DOI 10.2337/diacare.22.4.562
   Haffner SM, 2002, CIRCULATION, V106, P679, DOI 10.1161/01.CIR.0000025403.20953.23
   Hak AE, 2001, J CLIN ENDOCR METAB, V86, P4398, DOI 10.1210/jc.86.9.4398
   Hamdy O, 2003, DIABETES CARE, V26, P2119, DOI 10.2337/diacare.26.7.2119
   Han TS, 2002, DIABETES CARE, V25, P2016, DOI 10.2337/diacare.25.11.2016
   HEBELE RA, 2003, ARTERIOSCLER THROMB, V23, P111
   Heitzer T, 2001, CIRCULATION, V104, P2673, DOI 10.1161/hc4601.099485
   Heitzer T, 2000, DIABETOLOGIA, V43, P1435, DOI 10.1007/s001250051551
   HOLLENBERG SM, 1991, CHEST, V100, P1133, DOI 10.1378/chest.100.4.1133
   Holmäng A, 1999, DIABETES, V48, P106, DOI 10.2337/diabetes.48.1.106
   Honing MLH, 1998, DIABETES METAB REV, V14, P241, DOI 10.1002/(SICI)1099-0895(1998090)14:3<241::AID-DMR216>3.0.CO;2-R
   Hopfner RL, 1999, EUR J PHARMACOL, V374, P221, DOI 10.1016/S0014-2999(99)00316-7
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   HOTAMISLIGIL GS, 1995, J CLIN INVEST, V95, P2409, DOI 10.1172/JCI117936
   HU RM, 1993, DIABETES, V42, P351, DOI 10.2337/diabetes.42.2.351
   Ishii M, 2001, INT J BIOCHEM CELL B, V33, P65, DOI 10.1016/S1357-2725(00)00070-4
   Ito A, 2002, CIRC J, V66, P811, DOI 10.1253/circj.66.811
   Juhan-Vague I, 2000, ANN MED, V32, P78
   JuhanVague I, 1996, ANN MED, V28, P371, DOI 10.3109/07853899608999095
   Kannel WB, 2000, AM J HYPERTENS, V13, p3S, DOI 10.1016/S0895-7061(99)00252-6
   Karason K, 1999, INT J OBESITY, V23, P948, DOI 10.1038/sj.ijo.0801024
   Katakam PVG, 2001, AM J PHYSIOL-HEART C, V280, pH522, DOI 10.1152/ajpheart.2001.280.2.H522
   Kato K, 1999, BIOCHEM BIOPH RES CO, V258, P431, DOI 10.1006/bbrc.1999.0648
   Kotchen TA, 1997, AM J HYPERTENS, V10, P1020, DOI 10.1016/S0895-7061(97)00164-7
   Kruszynska YT, 2000, DIABETES, V49, P633, DOI 10.2337/diabetes.49.4.633
   Kubota N, 2002, J BIOL CHEM, V277, P25863, DOI 10.1074/jbc.C200251200
   Kurioka S, 2000, ENDOCR J, V47, P77, DOI 10.1507/endocrj.47.77
   LAAKSO M, 1990, DIABETES, V39, P965, DOI 10.2337/diabetes.39.8.965
   LAAKSO M, 1992, DIABETES, V41, P1076, DOI 10.2337/diabetes.41.9.1076
   Laight DW, 2000, EUR J PHARMACOL, V402, P95, DOI 10.1016/S0014-2999(00)00451-9
   Lavrencic A, 2000, ARTERIOSCL THROM VAS, V20, P551, DOI 10.1161/01.ATV.20.2.551
   LEVIN ER, 1995, NEW ENGL J MED, V333, P356, DOI 10.1056/NEJM199508103330607
   Lin KY, 2002, CIRCULATION, V106, P987, DOI 10.1161/01.CIR.0000027109.14149.67
   Martina V, 1998, THROMB HAEMOSTASIS, V79, P520
   Mason TM, 1999, DIABETES, V48, P524, DOI 10.2337/diabetes.48.3.524
   Mather KJ, 2000, J CLIN ENDOCR METAB, V85, P1851, DOI 10.1210/jc.85.5.1851
   Mather KJ, 2002, DIABETES, V51, P3517, DOI 10.2337/diabetes.51.12.3517
   Mather KJ, 2001, J AM COLL CARDIOL, V37, P1344, DOI 10.1016/S0735-1097(01)01129-9
   Mavri A, 2001, OBES RES, V9, P511, DOI 10.1038/oby.2001.67
   McAuley DF, 2000, CLIN SCI, V99, P175, DOI 10.1042/CS20000005
   MCNAMEE CJ, 1994, CIRC RES, V74, P1126, DOI 10.1161/01.RES.74.6.1126
   Meigs JB, 2000, JAMA-J AM MED ASSOC, V283, P221, DOI 10.1001/jama.283.2.221
   Meigs JB, 2003, DIABETES, V52, P2160, DOI 10.2337/diabetes.52.8.2160
   Michell BJ, 1999, CURR BIOL, V9, P845, DOI 10.1016/S0960-9822(99)80371-6
   Moller DE, 2000, TRENDS ENDOCRIN MET, V11, P212, DOI 10.1016/S1043-2760(00)00272-1
   MONCADA S, 1993, NEW ENGL J MED, V329, P2002
   Naderali EK, 2001, EUR J PHARMACOL, V416, P133, DOI 10.1016/S0014-2999(01)00866-4
   NAGI DK, 1993, DIABETES CARE, V16, P621, DOI 10.2337/diacare.16.4.621
   *NCEP, 2001, JAMA-J AM MED ASSOC, V285, P286
   NORDT TK, 1995, CIRCULATION, V91, P764, DOI 10.1161/01.CIR.91.3.764
   Nordt TK, 2001, DIABETOLOGIA, V44, P1121, DOI 10.1007/s001250100618
   OLIVER FJ, 1991, J BIOL CHEM, V266, P23251
   Ouchi N, 2003, HYPERTENSION, V42, P231, DOI 10.1161/01.HYP.0000083488.67550.B8
   Päivä H, 2003, J CARDIOVASC PHARM, V41, P219, DOI 10.1097/00005344-200302000-00010
   Pandolfi A, 1996, DIABETOLOGIA, V39, P1425, DOI 10.1007/s001250050594
   Pandolfi A, 2001, ACTA DIABETOL, V38, P71, DOI 10.1007/s005920170016
   Paquot N, 2000, J CLIN ENDOCR METAB, V85, P1316, DOI 10.1210/jc.85.3.1316
   Paradisi G, 2001, CIRCULATION, V103, P1410, DOI 10.1161/01.CIR.103.10.1410
   Paradisi G, 1999, DIABETES, V48, pA128
   Patti ME, 1999, DIABETES, V48, P1562, DOI 10.2337/diabetes.48.8.1562
   Perticone F, 2001, DIABETES, V50, P159, DOI 10.2337/diabetes.50.1.159
   Pessler D, 2001, DIABETOLOGIA, V44, P2156, DOI 10.1007/s001250100024
   Piatti P, 1996, DIABETES, V45, P316, DOI 10.2337/diabetes.45.3.316
   Pyörälä M, 2000, ARTERIOSCL THROM VAS, V20, P538, DOI 10.1161/01.ATV.20.2.538
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   REDDY KG, 1994, J AM COLL CARDIOL, V23, P833, DOI 10.1016/0735-1097(94)90627-0
   Retterstol L, 2003, ATHEROSCLEROSIS, V169, P279, DOI 10.1016/S0021-9150(03)00192-8
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   Ridker PM, 2000, NEW ENGL J MED, V342, P836, DOI 10.1056/NEJM200003233421202
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Rudich A, 1999, DIABETOLOGIA, V42, P949, DOI 10.1007/s001250051253
   Ruige JB, 1998, CIRCULATION, V97, P996
   Russell JC, 1998, DIABETOLOGIA, V41, P380, DOI 10.1007/s001250050920
   Sakamoto S, 1998, DIABETES, V47, P82, DOI 10.2337/diabetes.47.1.82
   Samad F, 2000, MOL MED, V6, P680, DOI 10.1007/BF03402048
   Sattar N, 2003, CIRCULATION, V108, P414, DOI 10.1161/01.CIR.0000080897.52664.94
   Schaefer SM, 2000, HUM BRAIN MAPP, V10, P1, DOI 10.1002/(SICI)1097-0193(200005)10:1<1::AID-HBM10>3.0.CO;2-O
   SCHERRER U, 1994, J CLIN INVEST, V94, P2511, DOI 10.1172/JCI117621
   Sekiya M, 2001, JPN CIRC J, V65, P487, DOI 10.1253/jcj.65.487
   Sewter CP, 1999, J ENDOCRINOL, V163, P33, DOI 10.1677/joe.0.1630033
   Shankar RR, 2000, DIABETES, V49, P684, DOI 10.2337/diabetes.49.5.684
   Sharma AC, 1999, ANN THORAC SURG, V67, P1659, DOI 10.1016/S0003-4975(99)00287-8
   Shimabukuro M, 2003, J CLIN ENDOCR METAB, V88, P3236, DOI 10.1210/jc.2002-021883
   Shinozaki K, 2001, J AM COLL CARDIOL, V38, P1821, DOI 10.1016/S0735-1097(01)01659-X
   Shinozaki K, 2000, CIRC RES, V87, P566, DOI 10.1161/01.RES.87.7.566
   STEINBERG D, 1989, NEW ENGL J MED, V320, P915
   Steinberg HO, 1997, J CLIN INVEST, V100, P1230, DOI 10.1172/JCI119636
   Steinberg HO, 2000, DIABETES, V49, P1231, DOI 10.2337/diabetes.49.7.1231
   STEINBERG HO, 1994, J CLIN INVEST, V94, P1172, DOI 10.1172/JCI117433
   Steinberg HO, 1996, J CLIN INVEST, V97, P2601, DOI 10.1172/JCI118709
   Steppan CM, 2001, NATURE, V409, P307, DOI 10.1038/35053000
   Stühlinger MC, 2002, JAMA-J AM MED ASSOC, V287, P1420, DOI 10.1001/jama.287.11.1420
   Surdacki A, 1999, J CARDIOVASC PHARM, V33, P652, DOI 10.1097/00005344-199904000-00020
   Tack CJJ, 1998, DIABETOLOGIA, V41, P569, DOI 10.1007/s001250050948
   TESFAMARIAM B, 1991, J CLIN INVEST, V87, P1643, DOI 10.1172/JCI115179
   Timimi FK, 1998, J AM COLL CARDIOL, V31, P552, DOI 10.1016/S0735-1097(97)00536-6
   Ting HH, 1996, J CLIN INVEST, V97, P22, DOI 10.1172/JCI118394
   van der Meer IM, 2003, ARCH INTERN MED, V163, P1323, DOI 10.1001/archinte.163.11.1323
   VELAZQUEZ EM, 1994, METABOLISM, V43, P647, DOI 10.1016/0026-0495(94)90209-7
   Verma S, 1997, EUR J PHARMACOL, V322, pR1, DOI 10.1016/S0014-2999(97)00104-0
   Verma S, 2000, J HYPERTENS, V18, P1445, DOI 10.1097/00004872-200018100-00012
   Verma S, 1996, AM J HYPERTENS, V9, P370, DOI 10.1016/0895-7061(95)00392-4
   Verma S, 1997, AM J HYPERTENS, V10, P1010, DOI 10.1016/S0895-7061(97)00107-6
   Verma S, 2003, CIRCULATION, V108, P736, DOI 10.1161/01.CIR.0000084503.91330.49
   Vicent D, 2003, J CLIN INVEST, V111, P1373, DOI 10.1172/JCI200315211
   WAGNER OF, 1992, J BIOL CHEM, V267, P16066
   Walker AB, 1999, DIABETES, V48, P1448, DOI 10.2337/diabetes.48.7.1448
   WANG P, 1994, AM J PHYSIOL, V266, pH2535, DOI 10.1152/ajpheart.1994.266.6.H2535
   Watanabe Y, 2000, J Atheroscler Thromb, V7, P159
   Winters B, 2000, J APPL PHYSIOL, V89, P2382, DOI 10.1152/jappl.2000.89.6.2382
   Wu SQ, 2000, CARDIOVASC RES, V45, P994, DOI 10.1016/S0008-6363(99)00417-4
   Xiong Y, 2003, J CARDIOVASC PHARM, V42, P191, DOI 10.1097/00005344-200308000-00006
   YAMAUCHI T, 1990, FEBS LETT, V267, P16, DOI 10.1016/0014-5793(90)80276-O
   Yamauchi T, 2001, NAT MED, V7, P941, DOI 10.1038/90984
   Yang WS, 2001, J CLIN ENDOCR METAB, V86, P3815, DOI 10.1210/jc.86.8.3815
   Yang WS, 2002, DIABETES CARE, V25, P376, DOI 10.2337/diacare.25.2.376
   Yudkin JS, 2000, ATHEROSCLEROSIS, V148, P209, DOI 10.1016/S0021-9150(99)00463-3
   Yudkin JS, 1999, ARTERIOSCL THROM VAS, V19, P972, DOI 10.1161/01.ATV.19.4.972
   Yusuf S, 2000, NEW ENGL J MED, V342, P154, DOI 10.1056/NEJM200001203420302
   Zeng GY, 1996, J CLIN INVEST, V98, P894, DOI 10.1172/JCI118871
   Zeng GY, 2000, CIRCULATION, V101, P1539, DOI 10.1161/01.CIR.101.13.1539
   Zinman B, 1999, J CLIN ENDOCR METAB, V84, P272, DOI 10.1210/jc.84.1.272
NR 179
TC 22
Z9 38
U1 1
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0828-282X
EI 1916-7075
J9 CAN J CARDIOL
JI Can. J. Cardiol.
PD AUG
PY 2004
VL 20
SU B
BP 66B
EP 76B
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology
GA 847UL
UT WOS:000223420600011
PM 15309208
DA 2025-06-11
ER

PT J
AU Sun, MX
   Huang, XQ
   Yan, Y
   Chen, JF
   Wang, ZZ
   Xie, MH
   Li, J
AF Sun, Mingxiao
   Huang, Xiuqing
   Yan, Yi
   Chen, Junfei
   Wang, Zhengzhen
   Xie, Minhao
   Li, Jian
TI Rac1 Is a Possible Link Between Obesity and Oxidative Stress in Chinese
   Overweight Adolescents
SO OBESITY
LA English
DT Article
ID INTIMA-MEDIA THICKNESS; INSULIN SENSITIVITY; METABOLIC SYNDROME; NADPH
   OXIDASE; GLUCOSE-TOLERANCE; HUMAN MONOCYTES; ANGIOTENSIN-II; CHILDREN;
   EXERCISE; AGE
AB Enhanced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity in the monocytes occurred in metabolic syndrome, hypertension, diabetes and obese patients in adults. However, whether NADPH oxidase is involved in the oxidative stress of overweight adolescents without comorbidities is still unclear. This study aimed to identify whether and how NADPH oxidase plays a crucial role in overweight adolescents. The study was performed in 93 overweight adolescents and 31 normal weight controls. Moreover, 87 overweight adolescents were enrolled in weight-loss program. Demographics characteristics, anthropometrics, composition and clinical characteristics were analyzed. Oxidative stress indexes including the levels of superoxide dismutase (SOD) and malondialdehyde (MDA) in plasma and the expression of NADPH oxidase in the monocytes were examined. Overweight adolescents showed a higher oxidative stress state, as indicated by decreased SOD activity and elevated MDA level (P < 0.01). Furthermore, increased NADPH oxidase activity in the monocytes was accompanied by Rac1 upregulation. A significant positive bivariate correlation was found between Rac1 expression and MDA (r = 0.289). There also was a significant positive bivariate correlation between Rac1 expression and obesity-related indexes including BMI (r = 0.227) and percentage of trunk fat (r = 0.233). Data from weight-loss program reinforced the results. Partial correlation analysis indicated that obesity-induced oxidative stress and Rac1 expression is a consequence of aberrant glucose-lipid metabolism in overweight adolescents. In conclusion, we provided novel data showing that NADPH oxidase in the monocytes was highly activated by enhancing Rac1 expression in Chinese overweight adolescents and Rac1 may act as a link between obesity and oxidative stress in overweight adolescents.
C1 [Sun, Mingxiao] Beijing Hosp, Key Lab Geriatr, Dept Endocrinol, Beijing, Peoples R China.
   [Sun, Mingxiao; Huang, Xiuqing; Li, Jian] Minist Hlth, Beijing Inst Geriatr, Beijing, Peoples R China.
   [Yan, Yi; Chen, Junfei; Wang, Zhengzhen; Xie, Minhao] Beijing Sports Univ, Sports Sci Coll, Beijing, Peoples R China.
C3 Beijing Hospital; Beijing Sport University
RP Li, J (corresponding author), Beijing Hosp, Key Lab Geriatr, Dept Endocrinol, Beijing, Peoples R China.
EM lijian@bjhmoh.cn
RI Junfei, Chen/K-7574-2012
FU National Basic Research Program of China [2012CB 517502]; National
   Social Science foundation; The Ministry of Education of China
   [BLA060052]; National Natural Science foundation of China [81070634,
   30801218]; National Natural Science Foundation of Beijing [7092090]
FX This project was funded by National Basic Research Program of China
   (2012CB 517502), National Social Science foundation, The Ministry of
   Education of China (BLA060052), National Natural Science foundation of
   China (81070634, 30801218), National Natural Science Foundation of
   Beijing (7092090).
CR Babior BM, 1999, BLOOD, V93, P1464, DOI 10.1182/blood.V93.5.1464.405a32_1464_1476
   Bonora E, 2000, DIABETES CARE, V23, P57, DOI 10.2337/diacare.23.1.57
   Chen CM, 2008, OBES REV, V9, P14, DOI 10.1111/j.1467-789X.2007.00433.x
   Cheng XW, 2008, AM J PATHOL, V173, P358, DOI 10.2353/ajpath.2008.071126
   Codoñer-Franch P, 2010, INT J PEDIATR OBES, V5, P56, DOI 10.3109/17477160903055945
   DUKE PM, 1980, PEDIATRICS, V66, P918
   Ferreira I, 2004, J HYPERTENS, V22, P145, DOI 10.1097/00004872-200401000-00024
   Fortuño A, 2006, DIABETES, V55, P209, DOI 10.2337/diabetes.55.1.209
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Giannini C, 2009, EUR J ENDOCRINOL, V161, P73, DOI 10.1530/EJE-09-0042
   Griendling KK, 2000, CIRC RES, V86, P494, DOI 10.1161/01.RES.86.5.494
   Huang XQ, 2011, DIABETES RES CLIN PR, V91, P371, DOI 10.1016/j.diabres.2010.12.026
   Johnson WD, 2009, ARCH PEDIAT ADOL MED, V163, P371, DOI 10.1001/archpediatrics.2009.3
   Oliver SR, 2010, INT J PEDIATR OBES, V5, P436, DOI 10.3109/17477160903545163
   Paffen E, 2004, ARTERIOSCL THROM VAS, V24, P975, DOI 10.1161/01.ATV.0000126681.16619.69
   Sniderman AD, 2003, CLIN BIOCHEM, V36, P499, DOI 10.1016/S0009-9120(03)00117-6
   Takahashi M, 2008, AM J PHYSIOL-HEART C, V294, pH2879, DOI 10.1152/ajpheart.91406.2007
   Ustundag B, 2007, CELL BIOCHEM FUNCT, V25, P479, DOI 10.1002/cbf.1334
   Van Pelt RE, 1998, AM J PHYSIOL-ENDOC M, V275, pE626, DOI 10.1152/ajpendo.1998.275.4.E626
   Vincent HK, 2006, INT J OBESITY, V30, P400, DOI 10.1038/sj.ijo.0803177
   Wycherley TP, 2008, DIABETES OBES METAB, V10, P1062, DOI 10.1111/j.1463-1326.2008.00863.x
   Yeckel CW, 2004, J CLIN ENDOCR METAB, V89, P1096, DOI 10.1210/jc.2003-031503
   Zhao XX, 2003, J BIOL CHEM, V278, P40788, DOI 10.1074/jbc.M302208200
   Zhu YG, 2006, BIOMED ENVIRON SCI, V19, P353
NR 24
TC 16
Z9 16
U1 0
U2 8
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1930-7381
J9 OBESITY
JI Obesity
PD NOV
PY 2012
VL 20
IS 11
BP 2233
EP 2240
DI 10.1038/oby.2012.63
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 029JS
UT WOS:000310492200010
PM 22421922
OA Bronze
DA 2025-06-11
ER

PT J
AU Kontoangelos, K
   Papageorgiou, CC
   Raptis, AE
   Tsiotra, P
   Lambadiari, V
   Papadimitriou, GN
   Rabavilas, AD
   Dimitriadis, G
   Raptis, SA
AF Kontoangelos, K.
   Papageorgiou, C. C.
   Raptis, A. E.
   Tsiotra, P.
   Lambadiari, V.
   Papadimitriou, G. N.
   Rabavilas, A. D.
   Dimitriadis, G.
   Raptis, S. A.
TI Homocysteine, Cortisol, Diabetes Mellitus, and Psychopathology
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Article
ID CARDIOVASCULAR RISK-FACTORS; PLASMA HOMOCYSTEINE; METABOLIC SYNDROME;
   DEPRESSION; ASSOCIATION; SCHIZOPHRENIA; TRAITS; STRESS; FOLATE
AB Objective. This study investigates the association of homocysteine and cortisol with psychological factors in type 2 diabetic patients. Method. Homocysteine, cortisol, and psychological variables were analyzed from 131 diabetic patients. Psychological factors were assessed with the Eysenck Personality Questionnaire (EPQ), Hostility and Direction of Hostility Questionnaire (HDHQ), the Symptom Checklist 90-R (SCL 90-R), the Zung Self-Rating Depression Scale (ZDRS), and the Maudsley O-C Inventory Questionnaire (MOCI). Blood samples were taken by measuring homocysteine and cortisol in both subgroups during the initial phase of the study (T0). One year later (T1), the uncontrolled diabetic patients were reevaluated with the use of the same psychometric instruments and with an identical blood analysis. Results. The relation of psychoticism and homocysteine is positive among controlled diabetic patients (P value = 0.006 < 0.05) and negative among uncontrolled ones (P value = 0.137). Higher values of cortisol correspond to lower scores on extraversion subscale (r(p) = -0.223, P value = 0.010). Controlled diabetic patients showed a statistically significant negative relationship between homocysteine and the act-out hostility subscale (r(sp) = -0.247, P = 0.023). There is a statistically significant relationship between homocysteine and somatization (r(sp) = -0.220, P = 0.043). Conclusions. These findings support the notion that homocysteine and cortisol are related to trait and state psychological factors in patients with diabetes mellitus type 2.
C1 [Kontoangelos, K.; Papageorgiou, C. C.; Papadimitriou, G. N.] Univ Athens, Eginit Hosp, Sch Med, Dept Psychiat 1, GR-11528 Athens, Greece.
   [Kontoangelos, K.; Papageorgiou, C. C.; Rabavilas, A. D.] Univ Mental Hlth Res Inst, Athens 11527, Greece.
   [Raptis, A. E.; Lambadiari, V.; Dimitriadis, G.; Raptis, S. A.] Univ Athens, Sch Med, Attikon Univ Hosp, Dept Internal Med 2,Res Inst, Athens 12462, Greece.
   [Raptis, A. E.; Lambadiari, V.; Dimitriadis, G.; Raptis, S. A.] Univ Athens, Sch Med, Attikon Univ Hosp, Ctr Diabet, Athens 12462, Greece.
   [Tsiotra, P.; Raptis, S. A.] Hellen Natl Ctr Res Prevent & Treatment Diabet Me, Athens 10675, Greece.
C3 Athens Medical School; National & Kapodistrian University of Athens;
   Athens Medical School; University Hospital Attikon; National &
   Kapodistrian University of Athens; University Hospital Attikon; National
   & Kapodistrian University of Athens; Athens Medical School
RP Kontoangelos, K (corresponding author), Univ Athens, Eginit Hosp, Sch Med, Dept Psychiat 1, GR-11528 Athens, Greece.
EM kontange@hol.gr
RI Tsiotra, Panayoula/AAE-6086-2019
OI Papageorgiou, Charalabos/0000-0001-7635-1956
CR Ahlberg AC, 2002, PSYCHIAT RES, V112, P101, DOI 10.1016/S0165-1781(02)00192-0
   Alexopoulos GS, 1997, ARCH GEN PSYCHIAT, V54, P915
   Almeida OP, 2007, AM J GERIAT PSYCHIAT, V15, P506, DOI 10.1097/01.JGP.0000246869.49892.77
   Atmaca M, 2005, PSYCHIAT CLIN NEUROS, V59, P616, DOI 10.1111/j.1440-1819.2005.01425.x
   Augner Christoph, 2009, Indian J Occup Environ Med, V13, P141, DOI 10.4103/0019-5278.58918
   BAXTER LR, 1989, ARCH GEN PSYCHIAT, V46, P243
   Bleich S, 2000, ADV RES NEURODEGENER, V8, P187
   Brown ES, 2004, BIOL PSYCHIAT, V55, P1, DOI 10.1016/S0006-3223(03)00473-6
   Bruehl H, 2007, J CLIN ENDOCR METAB, V92, P2439, DOI 10.1210/jc.2006-2540
   Burghardt KJ, 2013, MOL DIAGN THER, V17, P21, DOI 10.1007/s40291-013-0017-8
   de Luis DA, 2005, J DIABETES COMPLICAT, V19, P42, DOI 10.1016/j.jdiacomp.2003.12.003
   de Weerth C, 2003, EARLY HUM DEV, V73, P39, DOI 10.1016/S0378-3782(03)00074-4
   DEROGATIS LR, 1983, PSYCHOL MED, V13, P595, DOI 10.1017/S0033291700048017
   Dimitriou E, 1986, Engefalos, V23, P41
   Dinan TG, 2004, BRIT J PSYCHIAT, V184, pS72, DOI 10.1192/bjp.184.47.s72
   Donias S., 1991, Psychiatriki, V2, P42
   Eysenck HansJ., 1975, Manual of the EPQ (Personality Questionnaire)
   FOULDS GA, 1960, J MENT SCI, V106, P599, DOI 10.1192/bjp.106.443.599
   Fountoulakis KN, 2001, BMC PSYCHIATRY, V1, DOI 10.1186/1471-244X-1-6
   GOODWIN DW, 1969, ARCH GEN PSYCHIAT, V20, P182
   Hickie I, 2005, J AFFECT DISORDERS, V85, P327, DOI 10.1016/j.jad.2004.11.003
   HODGSON RJ, 1977, BEHAV RES THER, V15, P389, DOI 10.1016/0005-7967(77)90042-0
   Jensen E, 1998, ARCH GERONTOL GERIAT, V26, P215, DOI 10.1016/S0167-4943(98)00004-1
   Kale A, 2010, PSYCHIAT RES, V175, P47, DOI 10.1016/j.psychres.2009.01.013
   Kontoangelos K, 2012, EXP DIABETES RES, DOI 10.1155/2012/560864
   Kontoangelos K, 2013, INT J PSYCHIAT CLIN, V17, P48, DOI 10.3109/13651501.2012.697563
   Konukoglu D, 2005, CLIN HEMORHEOL MICRO, V33, P41
   Krebs MO, 2009, TRENDS MOL MED, V15, P562, DOI 10.1016/j.molmed.2009.10.001
   LeBlanc J, 2005, PHYSIOL BEHAV, V84, P677, DOI 10.1016/j.physbeh.2005.02.020
   Lonn E, 2006, NEW ENGL J MED, V354, P1567, DOI 10.1056/NEJMoa060900
   Marchesini G, 2002, NUTRITION, V18, P403, DOI 10.1016/S0899-9007(01)00803-6
   Mattson MP, 2003, TRENDS NEUROSCI, V26, P137, DOI 10.1016/S0166-2236(03)00032-8
   Misiak B, 2013, EPIGENOMICS-UK, V5, P317, DOI [10.2217/epi.13.22, 10.2217/EPI.13.22]
   Panagiotakos DB, 2004, MED SCI MONITOR, V10, pCR457
   POPE MK, 1991, PSYCHOSOM MED, V53, P386, DOI 10.1097/00006842-199107000-00004
   RACHMAN S, 1973, BEHAV RES THER, V11, P463, DOI 10.1016/0005-7967(73)90105-8
   Ramasubbu R, 2002, MED HYPOTHESES, V59, P537, DOI 10.1016/S0306-9877(02)00244-X
   ROSMOND R, 2003, MED SCI MONITOR, V9
   Sachdev PS, 2005, PROG NEURO-PSYCHOPH, V29, P1152, DOI 10.1016/j.pnpbp.2005.06.026
   TILLER JWG, 1988, BIOL PSYCHIAT, V23, P261, DOI 10.1016/0006-3223(88)90037-6
   Yasui K, 2000, NEUROLOGY, V55, P437, DOI 10.1212/WNL.55.3.437
   ZUNG WWK, 1965, ARCH GEN PSYCHIAT, V12, P63, DOI 10.1001/archpsyc.1965.01720310065008
NR 42
TC 12
Z9 12
U1 1
U2 6
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PY 2015
VL 2015
AR 354923
DI 10.1155/2015/354923
PG 10
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA CB6ZX
UT WOS:000349776700001
PM 25722989
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Cherniack, EP
AF Cherniack, E. Paul
TI A berry thought-provoking idea: the potential role of plant polyphenols
   in the treatment of age-related cognitive disorders
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Review
DE Fruits; Polyphenols; Cognition; Ageing
ID SUPPLEMENTATION IMPROVES MEMORY; NEURONAL SIGNAL-TRANSDUCTION; GREEN TEA
   POLYPHENOL; METABOLIC SYNDROME; BLUEBERRY SUPPLEMENTATION; DIETARY
   SUPPLEMENTATION; OXIDATIVE STRESS; HISTONE ACETYLATION; BEHAVIORAL
   DEFICITS; OLDER-ADULTS
AB Today, tens of millions of elderly individuals worldwide suffer from dementia. While the pathogenesis of dementia is complex and incompletely understood, it may be, at least to a certain extent, the consequence of systemic vascular pathology. The metabolic syndrome and its individual components induce a proinflammatory state that damages blood vessels. This condition of chronic inflammation may damage the vasculature of the brain or be directly neurotoxic. Associations have been established between the metabolic syndrome, its constituents and dementia. A relationship has also been observed between certain dietary factors, such as constituents of the 'Mediterranean diet', and the metabolic syndrome; similar associations have been noted between these dietary factors and dementia. Fruit juices and extracts are under investigation as treatments for cognitive impairment. Blueberry, strawberry, blackberry, grape and plum juices or extracts have been successfully tested in cognitively impaired rodents. Published trials of the benefits of grape and blueberry juice in the treatment of small numbers of cognitively impaired persons have recently appeared. The benefits of fruit products are thought to be a result of its polyphenol content. A grape polyphenol found in grapes, resveratrol, now being studied in humans, and one in grapes and blueberries, pterostilbene, have been found to improve cognition in rodents. In the design of future human trials, one ought to consider the poor bioavailability of these products, the possible need to initiate the experimental therapy long before the onset of symptoms, and currently limited knowledge about the appropriate form (e.g. juice, powder or individual polyphenol) of treatment.
C1 [Cherniack, E. Paul] Univ Miami, Sch Med,Miami Vet Affairs Med Ctr, Div Geriatr & Gerontol, Geriatr Inst,Geriatr & Extended Care Serv, Miami, FL 33125 USA.
   [Cherniack, E. Paul] Univ Miami, Sch Med, Miami Vet Affairs Med Ctr, Geriatr Res Educ & Clin Ctr, Miami, FL 33125 USA.
C3 University of Miami; Geriatric Research Education & Clinical Center;
   University of Miami
RP Cherniack, EP (corresponding author), Univ Miami, Sch Med,Miami Vet Affairs Med Ctr, Div Geriatr & Gerontol, Geriatr Inst,Geriatr & Extended Care Serv, Room 1D200,1201 NW 16th St, Miami, FL 33125 USA.
EM evan.cherniack@va.gov
CR Abete I, 2010, NUTR REV, V68, P214, DOI 10.1111/j.1753-4887.2010.00280.x
   Anstey Kaarin J, 2004, Aust Fam Physician, V33, P783
   Barberger-Gateau P, 2007, NEUROLOGY, V69, P1921, DOI 10.1212/01.wnl.0000278116.37320.52
   Boots AW, 2008, EUR J PHARMACOL, V585, P325, DOI 10.1016/j.ejphar.2008.03.008
   Borra MT, 2005, J BIOL CHEM, V280, P17187, DOI 10.1074/jbc.M501250200
   Bose M, 2008, J NUTR, V138, P1677, DOI 10.1093/jn/138.9.1677
   Bravo L, 1998, NUTR REV, V56, P317, DOI 10.1111/j.1753-4887.1998.tb01670.x
   Brown AL, 2009, BRIT J NUTR, V101, P886, DOI 10.1017/S0007114508047727
   Cacciapuoti F, 2009, METAB SYNDR RELAT D, V7, P397, DOI 10.1089/met.2008.0057
   Camargo A, 2010, BMC GENOMICS, V11, DOI 10.1186/1471-2164-11-253
   Casadesus G, 2004, NUTR NEUROSCI, V7, P309, DOI 10.1080/10284150400020482
   Cefalu WT, 2008, METABOLISM, V57, pS1, DOI 10.1016/j.metabol.2008.04.002
   Chan A, 2009, J ALZHEIMERS DIS, V16, P167, DOI 10.3233/JAD-2009-0959
   Cherniack EP, 2011, NUTRITION, V27, P617, DOI 10.1016/j.nut.2010.10.013
   Christensen H, 2001, AUST NZ J PSYCHIAT, V35, P768, DOI 10.1046/j.1440-1614.2001.00966.x
   Cottart CH, 2010, MOL NUTR FOOD RES, V54, P7, DOI 10.1002/mnfr.200900437
   Crandall JP, 2010, AM DIAB ASS 70 SCI S
   Crews WD, 2005, J ALTERN COMPLEM MED, V11, P305, DOI 10.1089/acm.2005.11.305
   Crozier A, 2010, MOL ASPECTS MED, V31, P446, DOI 10.1016/j.mam.2010.09.007
   Del Rio D, 2010, BRIT J NUTR, V104, pS67, DOI 10.1017/S0007114510003958
   Deng J-Y, 2005, 3 ANN WORLD C INS RE
   Devi SA, 2006, MED SCI MONITOR, V12, pBR124
   Dickstein DL, 2010, MT SINAI J MED, V77, P82, DOI 10.1002/msj.20155
   Duffy KB, 2008, NEUROBIOL AGING, V29, P1680, DOI 10.1016/j.neurobiolaging.2007.04.002
   Egert S, 2009, BRIT J NUTR, V102, P1065, DOI 10.1017/S0007114509359127
   Ford ES, 2005, DIABETES CARE, V28, P2745, DOI 10.2337/diacare.28.11.2745
   Frisardi V, 2010, AGEING RES REV, V9, P399, DOI 10.1016/j.arr.2010.04.007
   Galli RL, 2006, NEUROBIOL AGING, V27, P344, DOI 10.1016/j.neurobiolaging.2005.01.017
   Glisky E.L., 2007, Brain Aging: Models, Methods, and Mechanisms
   Goyarzu F, 2004, NUTR NEUROSCI, V7, P75, DOI 10.1080/10284150410001710410
   Gräff J, 2009, EUR J NEUROSCI, V30, P1, DOI 10.1111/j.1460-9568.2009.06787.x
   Gu YA, 2010, ARCH NEUROL-CHICAGO, V67, P699, DOI 10.1001/archneurol.2010.84
   Huber JL, 2010, FUTURE MED CHEM, V2, P1751, DOI [10.4155/fmc.10.257, 10.4155/FMC.10.257]
   Iraola-Guzmán S, 2011, CLIN GENET, V80, P1, DOI 10.1111/j.1399-0004.2011.01673.x
   Joseph JA, 1999, J NEUROSCI, V19, P8114
   Joseph JA, 1998, J NEUROSCI, V18, P8047
   Joseph JA, 2003, NUTR NEUROSCI, V6, P153, DOI 10.1080/1028415031000111282
   Joseph JA, 2009, J NUTR, V139, p1813S, DOI 10.3945/jn.109.108266
   Joseph JA, 2008, J AGR FOOD CHEM, V56, P10544, DOI 10.1021/jf802279h
   Kelley BJ, 2007, NEUROL CLIN, V25, P577, DOI 10.1016/j.ncl.2007.03.008
   Kim S, 2011, BIOCHEM PHARMACOL, V81, P1343, DOI 10.1016/j.bcp.2011.03.012
   Krikorian R, 2010, J AGR FOOD CHEM, V58, P3996, DOI 10.1021/jf9029332
   Krikorian R, 2010, BRIT J NUTR, V103, P730, DOI 10.1017/S0007114509992364
   Kumar A, 2007, PHARMACOLOGY, V79, P17, DOI 10.1159/000097511
   Liebson Philip R, 2010, Prev Cardiol, V13, P94, DOI 10.1111/j.1751-7141.2009.00064.x
   Manach C, 2005, AM J CLIN NUTR, V81, p230S, DOI 10.1093/ajcn/81.1.230S
   Mastroeni D, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006617
   Nassiri-Asl M, 2009, PHYTOTHER RES, V23, P1197, DOI 10.1002/ptr.2761
   National Institutes of Health Clinical Trials.gov, 2010, RAND TRIAL NUTR S
   National Institutes of Health Clinical Trials.gov, 2010, MECH MET REG RESV HU
   National Institutes of Health Clinical Trials.gov, 2010, EFF BILB EUR BLUEB G
   National Institutes of Health Clinical Trials.gov, 2010, PIL STUD EFF RESV S
   National Institutes of Health Clinical Trials.gov, 2010, EFF RESV COMP CAL RE
   Obunai K, 2007, MED CLIN N AM, V91, P1169, DOI 10.1016/j.mcna.2007.06.003
   Ono K, 2008, J BIOL CHEM, V283, P32176, DOI 10.1074/jbc.M806154200
   Peleg S, 2010, SCIENCE, V328, P753, DOI 10.1126/science.1186088
   Pinent M, 2005, INT J OBESITY, V29, P934, DOI 10.1038/sj.ijo.0802988
   Poudyal H, 2010, J NUTR, V140, P946, DOI 10.3945/jn.109.117812
   Querfurth HW, 2010, NEW ENGL J MED, V362, P329, DOI 10.1056/NEJMra0909142
   Rayalam S, 2008, J NUTR BIOCHEM, V19, P717, DOI 10.1016/j.jnutbio.2007.12.007
   Remington R, 2010, AM J ALZHEIMERS DIS, V25, P367, DOI 10.1177/1533317510363470
   Rocha KKR, 2009, FOOD CHEM TOXICOL, V47, P1362, DOI 10.1016/j.fct.2009.03.010
   Rogers E J, 2004, J Nutr Health Aging, V8, P92
   Rossi L, 2008, NEUROCHEM RES, V33, P2390, DOI 10.1007/s11064-008-9696-7
   Roth RM., 2005, PSYCHOLOGISTS DESK R, V2nd, P38
   Rumawas ME, 2009, AM J CLIN NUTR, V90, P1608, DOI 10.3945/ajcn.2009.27908
   Sakata Y, 2010, EXP NEUROL, V224, P325, DOI 10.1016/j.expneurol.2010.03.032
   Scalbert A, 2000, J NUTR, V130, p2073S, DOI 10.1093/jn/130.8.2073S
   Schmatz R, 2009, EUR J PHARMACOL, V610, P42, DOI 10.1016/j.ejphar.2009.03.032
   Sharma M, 2002, LIFE SCI, V71, P2489, DOI 10.1016/S0024-3205(02)02083-0
   Shukitt-Hale B, 2008, J AGR FOOD CHEM, V56, P636, DOI 10.1021/jf072505f
   Shukitt-Hale B, 2005, AGE, V27, P49, DOI 10.1007/s11357-005-4004-9
   Shukitt-Hale B, 2009, NUTR NEUROSCI, V12, P135, DOI 10.1179/147683009X423292
   Shukitt-Hale B, 2009, NUTRITION, V25, P567, DOI 10.1016/j.nut.2008.10.018
   Sivaprakasapillai B, 2009, METABOLISM, V58, P1743, DOI 10.1016/j.metabol.2009.05.030
   Sönmez U, 2007, NEUROSCI LETT, V420, P133, DOI 10.1016/j.neulet.2007.04.070
   Stilling RM, 2011, NEUROBIOL LEARN MEM, V96, P19, DOI 10.1016/j.nlm.2011.04.002
   Sweatt JD, 2007, NATURE, V447, P151, DOI 10.1038/nature05716
   Tchantchou F, 2005, J ALZHEIMERS DIS, V8, P283
   Wang J, 2008, J NEUROSCI, V28, P6388, DOI 10.1523/JNEUROSCI.0364-08.2008
   Wang SC, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002698
   Williams RJ, 2012, FREE RADICAL BIO MED, V52, P35, DOI 10.1016/j.freeradbiomed.2011.09.010
NR 82
TC 50
Z9 55
U1 0
U2 72
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD SEP 14
PY 2012
VL 108
IS 5
BP 794
EP 800
DI 10.1017/S0007114512000669
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 000DB
UT WOS:000308365600005
PM 22475317
DA 2025-06-11
ER

PT J
AU Wu, T
   Sun, JN
   Kagota, S
   Maruyama, K
   Wakuda, H
   Shinozuka, K
AF Wu, Ting
   Sun, Jianning
   Kagota, Satomi
   Maruyama, Kana
   Wakuda, Hirokazu
   Shinozuka, Kazumasa
TI Panax notoginseng saponins ameliorate impaired arterial vasodilation in
   SHRSP.Z-Lepr<SUP>fa</SUP>/lzmDmcr rats with metabolic syndrome
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article
DE metabolic syndrome; nitric oxide; Panax notoginseng saponins;
   vasodilation
ID SHR/NDMCR-CP RATS; ANIMAL-MODEL; ATHEROSCLEROTIC LESIONS; DYSFUNCTION;
   EXPRESSION; TELMISARTAN; RECEPTORS; ZYMOSAN; STRESS; INJURY
AB Panax notoginseng saponins (PNS) are major components of Panax notoginseng, a herb with established clinical efficacyagainst vascular diseases. SHRSP.Z-Lepr(fa)/IzmDmcr (SHRSP.ZF) rats, a new animal model for metabolic syndrome, display an impaired vasorelaxation response in aortas and mesenteric arteries that is mediated by nitric oxide (NO). This study investigated whether PNS and its components can ameliorate this vascular dysfunction in SHRSP.ZF rats. In an invitro study, in the presence or absence of PNS and its components, vasodilation in response to nitroprusside was determined from myographs under isometric tension conditions in aortas and mesenteric arteries from male SHRSP.ZF rats at 18-20weeks of age. In an invivo study, PNS (30mg/kg per day) was orally administered to SHRSP.ZF rats from 8 to 20weeks of age. In vitro treatment with PNS and Ginsenoside Rb-1 increased nitroprusside-induced relaxation of aortas and mesenteric arteries in SHRSP.ZF rats. The PNS-induced increase was not affected by a nitric oxide (NO) synthase inhibitor or endothelium denudation. Relaxation in response to a cell-permeable cGMP analogue was increased by PNS, but cGMP accumulation by nitroprusside was not altered. In vivo treatment with PNS in SHRSP.ZF rats lowered blood pressure and increased relaxation and the expression of soluble guanylyl cyclase protein in arteries, without affecting metabolic abnormalities. These results indicate that PNS causes an increase in vasodilation in response to NO and a decrease in blood pressure, resulting in protection against vascular dysfunction in SHRSP.ZF rats. PNS might be beneficial in alleviating impaired vasodilation in metabolic syndrome.
C1 [Wu, Ting; Sun, Jianning] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing, Peoples R China.
   [Kagota, Satomi; Maruyama, Kana; Wakuda, Hirokazu; Shinozuka, Kazumasa] Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Nishinomiya, Hyogo 6638179, Japan.
C3 Beijing University of Chinese Medicine; Mukogawa Women's University
RP Kagota, S (corresponding author), Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Nishinomiya, Hyogo 6638179, Japan.
EM skagota@mukogawa-u.ac.jp
RI Wakuda, Hirokazu/KZU-6319-2024
OI Wakuda, Hirokazu/0000-0002-5717-8251
CR GUAN YY, 1994, ACTA PHARM SINIC, V15, P392
   Gui QF, 2013, NEURAL REGEN RES, V8, P792, DOI 10.3969/j.issn.1673-5374.2013.09.003
   Hiraoka-Yamamoto J, 2004, CLIN EXP PHARMACOL P, V31, P107, DOI 10.1111/j.1440-1681.2004.04121.x
   Kagota S, 2006, LIFE SCI, V78, P1187, DOI 10.1016/j.lfs.2005.06.029
   Kagota S, 2014, VASC PHARMACOL, V63, P46, DOI 10.1016/j.vph.2014.06.005
   Kagota S, 2013, MICROVASC RES, V88, P70, DOI 10.1016/j.mvr.2013.04.001
   Kagota S, 2011, CAN J PHYSIOL PHARM, V89, P355, DOI [10.1139/Y11-029, 10.1139/y11-029]
   Kagota S, 2010, CLIN EXP PHARMACOL P, V37, P1035, DOI 10.1111/j.1440-1681.2010.05432.x
   Kagota S, 2009, J PHARMACOL SCI, V109, P556, DOI 10.1254/jphs.08273FP
   Kubota Y, 2006, BIOL PHARM BULL, V29, P1756, DOI 10.1248/bpb.29.1756
   Kuo TH, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000001032
   Kwan CY, 2000, ACTA PHARMACOL SIN, V21, P1101
   Li H, 2009, J ETHNOPHARMACOL, V121, P412, DOI 10.1016/j.jep.2008.10.042
   Li XY, 2007, BIOL PHARM BULL, V30, P847, DOI 10.1248/bpb.30.847
   Lin F, 2013, INT J IMPOT RES, V25, P206, DOI 10.1038/ijir.2013.19
   Lin XH, 2015, J SURG RES, V195, P334, DOI 10.1016/j.jss.2014.12.047
   Liu Y, 2013, CELL PHYSIOL BIOCHEM, V32, P814, DOI 10.1159/000354484
   Liu Y, 2010, BIOL PHARM BULL, V33, P1324, DOI 10.1248/bpb.33.1324
   Maury E, 2010, MOL CELL ENDOCRINOL, V314, P1, DOI 10.1016/j.mce.2009.07.031
   Pan CS, 2012, VASC PHARMACOL, V56, P150, DOI 10.1016/j.vph.2011.12.006
   Raij Leopoldo, 2006, J Clin Hypertens (Greenwich), V8, P30, DOI 10.1111/j.1524-6175.2006.06025.x
   Shaw DI, 2005, P NUTR SOC, V64, P349, DOI 10.1079/PNS2005442
   Shen KK, 2014, BIOCHEM PHARMACOL, V88, P66, DOI 10.1016/j.bcp.2014.01.007
   Strisciuglio T, 2014, CURR ATHEROSCLER REP, V16, DOI 10.1007/s11883-014-0417-1
   Sugiyama F, 2013, CLIN EXP NEPHROL, V17, P515, DOI 10.1007/s10157-012-0759-3
   Tada Y, 2010, BIOL PHARM BULL, V33, P1971, DOI 10.1248/bpb.33.1971
   Ueno T, 2008, HYPERTENS RES, V31, P1021, DOI 10.1291/hypres.31.1021
   Ueno T, 2009, INT J MOL MED, V23, P313, DOI 10.3892/ijmm_00000133
   Venkatapuram Suneetha, 2006, Am J Ther, V13, P64, DOI 10.1097/00045391-200601000-00011
   Wan JB, 2009, J AGR FOOD CHEM, V57, P6692, DOI 10.1021/jf900529w
   Wang M, 2014, J ETHNOPHARMACOL, V155, P240, DOI 10.1016/j.jep.2014.05.024
   Wu JH, 2013, J FUNCT FOODS, V5, P1159, DOI 10.1016/j.jff.2013.03.013
   Xu X, 2015, INT J CLIN EXP MED, V8, P1768
   Yang XC, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/204840
   Yang XC, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/948319
   Yoshitomi H, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-13
   Yuan ZM, 2011, J ETHNOPHARMACOL, V138, P150, DOI 10.1016/j.jep.2011.08.066
   Zeng XS, 2014, CAN J PHYSIOL PHARM, V92, P102, DOI 10.1139/cjpp-2013-0274
   Zhou LJ, 2015, J CHROMATOGR B, V995, P46, DOI 10.1016/j.jchromb.2015.05.022
NR 39
TC 12
Z9 12
U1 0
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1870
EI 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD APR
PY 2016
VL 43
IS 4
BP 459
EP 467
DI 10.1111/1440-1681.12547
PG 9
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA DH6KX
UT WOS:000372900500008
PM 26784885
DA 2025-06-11
ER

PT J
AU Fürst-Recktenwald, S
   Dörr, HG
   Quinkler, M
   Dötsch, J
   Stewart, PM
AF Fuerst-Recktenwald, Sabine
   Doerr, Helmuth G.
   Quinkler, Marcus
   Doetsch, Joerg
   Stewart, Paul M.
TI Is there sufficient evidence to consider the use of 11β-hydroxysteroid
   dehydrogenase type 1 inhibition in children?
SO CLINICAL ENDOCRINOLOGY
LA English
DT Review
ID CORTISONE-REDUCTASE DEFICIENCY; MESSENGER-RNA EXPRESSION;
   ADIPOSE-TISSUE; GROWTH-HORMONE; HEXOSE-6-PHOSPHATE DEHYDROGENASE;
   METABOLIC SYNDROME; HEALTHY-CHILDREN; IN-VIVO; MODULATION; OBESITY
AB Manifestations of the metabolic syndrome [obesity, dyslipidaemia, hypertension, blood glucose derangements including prediabetes or type 2 diabetes mellitus (T2DM)] in juvenile populations are becoming increasingly prevalent throughout the world and are at the point of being a global public health concern. Derangements in cortisol regeneration seem to be involved in the pathophysiology. Treatment with selective 11 beta-hydroxysteroid dehydrogenase 1 (11 beta-HSD1) inhibitors could be a therapeutic strategy in paediatric patients with manifestations of the metabolic syndrome. Based on preclinical and clinical data regarding development of the 11 beta-HSD1 enzyme, it appears that maturation occurs within the first year of life. Different changes in biomarkers for assessing the efficacy and safety of 11 beta-HSD1 inhibitors are to be expected in paediatric patients compared to adults, reflecting differences in metabolism. The effect of 11 beta-HSD1 treatment in children on bone differentiation and development as well as adrenocorticotropic hormone (ACTH), circulating and local cortisol tissue concentrations, androgens and respective stress response is not yet known. Based on current literature, the concept of inhibition of 11 beta-HSD1 is considered a potentially effective mean to regulate local cortisol levels in the paediatric population, and 11 beta-HSD1 inhibitors may provide a valuable target and treatment option for the metabolic syndrome in paediatric patients. However, the uncertainty over effects on the developing skeleton combined with mild increases in adrenal androgen levels raises potential concerns regarding growth as well as onset of puberty as to their future use in children. Future clinical studies are needed to thoroughly assess the risks and benefits of this new class of drugs in the paediatric population.
C1 [Fuerst-Recktenwald, Sabine] F Hoffmann La Roche Ltd, Basel, Switzerland.
   [Doerr, Helmuth G.] Univ Erlangen Nurnberg, Dept Pediat, D-91054 Erlangen, Germany.
   [Quinkler, Marcus] Charite, Charite Campus Mitte, D-13353 Berlin, Germany.
   [Doetsch, Joerg] Univ Cologne, Dept Pediat, D-50931 Cologne, Germany.
   [Stewart, Paul M.] Univ Birmingham, Sch Clin & Expt Med, Birmingham, W Midlands, England.
C3 Roche Holding; University of Erlangen Nuremberg; Berlin Institute of
   Health; Free University of Berlin; Humboldt University of Berlin;
   Charite Universitatsmedizin Berlin; University of Cologne; University of
   Birmingham
RP Fürst-Recktenwald, S (corresponding author), F Hoffmann La Roche Ltd, Basel, Switzerland.
EM sabine.fuerst-recktenwald@roche.com
RI Doerr, Helmuth/LYO-3879-2024
OI Quinkler, Marcus/0000-0003-4028-1671
FU F. Hoffmann-La Roche Ltd.
FX Medical writing support was funded by F. Hoffmann-La Roche Ltd.
CR Andrew R, 2002, J CLIN ENDOCR METAB, V87, P277, DOI 10.1210/jc.87.1.277
   Andrews RC, 2002, J CLIN ENDOCR METAB, V87, P5587, DOI 10.1210/jc.2002-020048
   Basu R, 2009, DIABETES, V58, P39, DOI 10.2337/db08-1079
   Bujalska IJ, 2006, J MOL ENDOCRINOL, V37, P327, DOI 10.1677/jme.1.02048
   Cooper MS, 2002, J BONE MINER RES, V17, P979, DOI 10.1359/jbmr.2002.17.6.979
   Cooper MS, 2000, BONE, V27, P375, DOI 10.1016/S8756-3282(00)00344-6
   Courtney R, 2008, J CLIN ENDOCR METAB, V93, P550, DOI 10.1210/jc.2007-1912
   Dannemann A, 2011, ACTA PAEDIATR, V100, P578, DOI 10.1111/j.1651-2227.2010.02119.x
   Dieudonné MN, 2006, J STEROID BIOCHEM, V99, P189, DOI 10.1016/j.jsbmb.2006.01.007
   Dimitriou T, 2003, AM J CLIN NUTR, V77, P731, DOI 10.1093/ajcn/77.3.731
   Dötsch J, 2000, PEDIATR RES, V48, P697
   Draper N, 2003, NAT GENET, V34, P434, DOI 10.1038/ng1214
   Edgerton DS, 2010, AM J PHYSIOL-ENDOC M, V298, pE1019, DOI 10.1152/ajpendo.00740.2009
   Feig PU, 2011, DIABETES OBES METAB, V13, P498, DOI 10.1111/j.1463-1326.2011.01375.x
   Friedberg M, 2003, J CLIN ENDOCR METAB, V88, P385, DOI 10.1210/jc.2002-020510
   Fuerst-Recktenwald S., 2011, ENDOCRINE REV, V32
   Gelernter-Yaniv L, 2003, INT J OBESITY, V27, P983, DOI 10.1038/sj.ijo.0802327
   Gibbs JP, 2011, J CLIN PHARMACOL, V51, P830, DOI 10.1177/0091270010374470
   Gnanalingham MG, 2005, AM J PHYSIOL-REG I, V289, pR1407, DOI 10.1152/ajpregu.00375.2005
   Gomez-Sanchez EP, 2003, AM J PHYSIOL-ENDOC M, V285, pE272, DOI 10.1152/ajpendo.00409.2002
   Goodyer IM, 2001, BRIT J PSYCHIAT, V179, P243, DOI 10.1192/bjp.179.3.243
   HAMMAMI MM, 1991, J CLIN ENDOCR METAB, V73, P326, DOI 10.1210/jcem-73-2-326
   Jamieson A, 1999, J CLIN ENDOCR METAB, V84, P3570, DOI 10.1210/jc.84.10.3570
   Jamieson P. M., 1990, J ENDOCRINOL, V160, P103
   Justesen J, 2004, ENDOCRINOLOGY, V145, P1916, DOI 10.1210/en.2003-1427
   KIESS W, 1995, PEDIATR RES, V37, P502, DOI 10.1203/00006450-199504000-00020
   Knutsson U, 1997, J CLIN ENDOCR METAB, V82, P536, DOI 10.1210/jc.82.2.536
   Konopelska S, 2009, CLIN ENDOCRINOL, V70, P554, DOI 10.1111/j.1365-2265.2008.03358.x
   Kushnir MM, 2010, CLIN CHEM, V56, P1138, DOI 10.1373/clinchem.2010.143222
   Lavery GG, 2008, J CLIN ENDOCR METAB, V93, P3827, DOI 10.1210/jc.2008-0743
   Lawson AJ, 2011, P NATL ACAD SCI USA, V108, P4111, DOI 10.1073/pnas.1014934108
   Leckie CM, 1998, J ENDOCRINOL, V159, P233, DOI 10.1677/joe.0.1590233
   Li X, 2007, INT J OBESITY, V31, P820, DOI 10.1038/sj.ijo.0803470
   Liu YJ, 1998, METABOLISM, V47, P474, DOI 10.1016/S0026-0495(98)90062-2
   Maheu FS, 2008, PSYCHONEUROENDOCRINO, V33, P238, DOI 10.1016/j.psyneuen.2007.11.006
   MAIN K, 1991, HORM RES, V36, P174, DOI 10.1159/000182156
   Malunowicz EM, 2003, HORM RES, V59, P205, DOI 10.1159/000069326
   Mericq V, 2009, HORM RES, V71, P89, DOI 10.1159/000183897
   Misra M, 2004, J CLIN ENDOCR METAB, V89, P4972, DOI 10.1210/jc.2004-0723
   Moore JS, 1999, J CLIN ENDOCR METAB, V84, P4172, DOI 10.1210/jc.84.11.4172
   Morton NM, 2001, J BIOL CHEM, V276, P41293, DOI 10.1074/jbc.M103676200
   MURPHY BEP, 1981, J STEROID BIOCHEM, V14, P811
   Paterson JM, 2004, P NATL ACAD SCI USA, V101, P7088, DOI 10.1073/pnas.0305524101
   Paulsen SK, 2006, J CLIN ENDOCR METAB, V91, P1093, DOI 10.1210/jc.2005-1694
   Phillipov G, 1996, J CLIN ENDOCR METAB, V81, P3855, DOI 10.1210/jc.81.11.3855
   Quinkler M, 2004, J ENDOCRINOL, V183, P331, DOI 10.1677/joe.1.05762
   Rajan V, 1996, J NEUROSCI, V16, P65
   Rask E, 2002, J CLIN ENDOCR METAB, V87, P3330, DOI 10.1210/jc.87.7.3330
   Raul JS, 2004, CLIN BIOCHEM, V37, P1105, DOI 10.1016/j.clinbiochem.2004.02.010
   Reinehr T, 2004, HORM RES, V62, P107, DOI 10.1159/000079841
   Rosenstock J, 2010, DIABETES CARE, V33, P1516, DOI 10.2337/dc09-2315
   Sangun O, 2011, J CLIN RES PEDIATR E, V3, P70, DOI 10.4274/jcrpe.v3i2.15
   Schäcke H, 2002, PHARMACOL THERAPEUT, V96, P23, DOI 10.1016/S0163-7258(02)00297-8
   Seckl JR, 2004, RECENT PROG HORM RES, V59, P359, DOI 10.1210/rp.59.1.359
   Shah S, 2011, J AM SOC HYPERTENS, V5, P166, DOI 10.1016/j.jash.2011.01.009
   Shi LJ, 2011, STEROIDS, V76, P140, DOI 10.1016/j.steroids.2010.10.004
   Stewart PM, 1999, J CLIN ENDOCR METAB, V84, P1022, DOI 10.1210/jc.84.3.1022
   Stewart PM, 1995, J STEROID BIOCHEM, V55, P465, DOI 10.1016/0960-0760(95)00195-6
   Tomlinson J. W., 2008, DIABETES, V57, P1
   Wan SL, 2002, J NEUROSCI RES, V69, P681, DOI 10.1002/jnr.10325
   Wei C, 2011, ARCH DIS CHILD, V96, P1003, DOI 10.1136/adc.2010.190975
   Weiss R, 2004, NEW ENGL J MED, V350, P2362, DOI 10.1056/NEJMoa031049
   Wiegand S, 2007, EUR J ENDOCRINOL, V157, P319, DOI 10.1530/EJE-07-0193
   Wudy SA, 2007, AM J PHYSIOL-ENDOC M, V293, pE970, DOI 10.1152/ajpendo.00495.2006
   Yamada J, 2007, NEONATOLOGY, V92, P42, DOI 10.1159/000100085
   YANG K, 1995, J MOL ENDOCRINOL, V14, P109, DOI 10.1677/jme.0.0140109
   Zhu LJ, 2010, J CLIN ENDOCR METAB, V95, P3300, DOI 10.1210/jc.2009-2708
NR 67
TC 0
Z9 0
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD AUG
PY 2012
VL 77
IS 2
BP 159
EP 168
DI 10.1111/j.1365-2265.2012.04406.x
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 971SF
UT WOS:000306223400001
PM 22486586
OA Bronze
DA 2025-06-11
ER

PT J
AU Meguro, K
   Svensson, T
   Chung, UI
   Svensson, AK
AF Meguro, Keiko
   Svensson, Thomas
   Chung, Ung-il
   Svensson, Akiko K.
TI Associations of work-related stress and total sleep time with
   cholesterol levels in an occupational cohort of Japanese office workers
SO JOURNAL OF OCCUPATIONAL HEALTH
LA English
DT Article
DE cholesterol level; occupational cohort; the Brief Job Stress
   Questionnaire; total sleep time; wearable device
ID CARDIOVASCULAR-DISEASE; DURATION; RISK; MEN
AB Objective The aim of the study was to investigate the associations of total sleep time (TST) and occupational stress based on the Brief Job Stress Questionnaire (BJSQ) with cholesterol levels in an occupational cohort of Japanese office workers. Methods The present study is a secondary analysis of a subset of participants from a randomized controlled trial. Participants were 179 employees from 5 companies in Tokyo who participated as the intervention group in a 3-month lifestyle intervention study among office workers with metabolic syndrome or at risk of metabolic syndrome. All intervention-group participants used a mobile app and a wearable device. The final population for analysis in the present study were 173 participants. Cholesterol measures were derived from participants' annual health check-up data in the fiscal year preceding their inclusion in the study. Multiple linear regression models were used to determine the association between exposures and outcome. Results Overall, stress levels were significantly and inversely associated with LDL-C (-7.12 mg/dl; 95% CI: -11.78, -2.45) and LDL-C/HDL-C ratio (-0.16 mg/dl; 95% CI: -0.27, -0.04) per standard deviation increase. Compared to average TST 5.9-7.2 hours, average TST of 4.0-5.3 hours (-4.82 mg/dl; 95% CI: -9.22, -0.43) was inversely associated with HDL-C. Conclusion Incremental increases of stress were significantly and inversely associated with LDL-C and LDL-C/HDL-C ratio. The shortest average TST was inversely associated with HDL-C. The results should be interpreted with care given certain methodological limitations.
C1 [Meguro, Keiko; Svensson, Thomas; Chung, Ung-il; Svensson, Akiko K.] Univ Tokyo, Precis Hlth, Dept Bioengn, Grad Sch Engn,Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
   [Meguro, Keiko; Svensson, Thomas; Chung, Ung-il] Kanagawa Univ, Sch Hlth Innovat, Human Serv Grad Sch, Kawasaki, Kanagawa, Japan.
   [Svensson, Thomas; Svensson, Akiko K.] Lund Univ, Skane Univ Hosp, Dept Clin Sci, Malmo, Sweden.
   [Chung, Ung-il] Univ Tokyo, Ctr Dis Biol & Integrat Med, Grad Sch Med, Clin Biotechnol, Tokyo, Japan.
   [Svensson, Akiko K.] Univ Tokyo, Dept Diabet & Metab Dis, Bunkyo Ku, Tokyo, Japan.
C3 University of Tokyo; Lund University; Skane University Hospital;
   University of Tokyo; University of Tokyo
RP Svensson, T (corresponding author), Univ Tokyo, Precis Hlth, Dept Bioengn, Grad Sch Engn,Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM thomas.svensson@med.lu.se
RI Svensson, Thomas/AAJ-4578-2020
OI Meguro, Keiko/0000-0002-1259-143X
FU Center of Innovation Program from the Japan Science and Technology
   Agency, JST [JPMJCE1304]; Kanagawa prefecture's "A project to expand the
   use of metabolic syndrome risk index in municipalities" (2018)
FX This research was supported by the Center of Innovation Program from the
   Japan Science and Technology Agency, JST (Grant Number JPMJCE1304) and
   Kanagawa prefecture's "A project to expand the use of metabolic syndrome
   risk index in municipalities" (2018).
CR Assadi SN, 2017, MEDICINE, V96, DOI [10.1097/MD.0000000000006816, 10.1097/md.0000000000006816]
   Beydoun MA, 2011, J EPIDEMIOL COMMUN H, V65, P949, DOI 10.1136/jech.2009.100826
   Cao B, 2020, SLEEP BREATH, V24, P1507, DOI 10.1007/s11325-020-02016-1
   Doo H, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000005360
   Ference BA, 2017, EUR HEART J, V38, P2459, DOI 10.1093/eurheartj/ehx144
   Fernandez-Mendoza J, 2017, J HYPERTENS, V35, P830, DOI 10.1097/HJH.0000000000001253
   Garbarino S, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0144318
   Hamazaki Y, 2011, SCAND J WORK ENV HEA, V37, P411, DOI 10.5271/sjweh.3168
   Harland JI, 2012, NUTR RES REV, V25, P249, DOI 10.1017/S0954422412000170
   Kaneita Y, 2008, SLEEP, V31, P645, DOI 10.1093/sleep/31.5.645
   Ke Der-Shin, 2012, Acta Neurol Taiwan, V21, P54
   Kinuhata S, 2014, SLEEP MED, V15, P1379, DOI 10.1016/j.sleep.2014.06.011
   Krajnak KM, 2014, ENVIRON HEALTH INSIG, V8, P41, DOI 10.4137/EHI.S15263
   Latifi SM, 2017, DIABETES METAB SYND, V11, pS751, DOI 10.1016/j.dsx.2017.05.010
   Lauderdale DS, 2008, EPIDEMIOLOGY, V19, P838, DOI 10.1097/EDE.0b013e318187a7b0
   Lemieux I, 2001, ARCH INTERN MED, V161, P2685, DOI 10.1001/archinte.161.22.2685
   Liau AK, 2018, CYBERPSYCH BEH SOC N, V21, P727, DOI 10.1089/cyber.2016.0502
   Ministry of Health Labour and Welfare, 2016, STRESS CHECK PROGR I
   Ministry of Health Labour and Welfare, 2016, REP ANN HLTH CHECK U
   Ministry of Health Labour and Welfare, OCCUPATIONAL STRESS
   Ministry of Health Labour and Welfare, 2018, STAND MED EX HLTH GU
   Ministry of Health Labour and Welfare . Health science council, 2015, 1 M SPEC COMM HLTH E
   Office for Policy on WorkLife Balance, 2014, SURV WORK LIF BAL LA
   Okami Y, 2019, J ATHEROSCLER THROMB, V26, P170, DOI 10.5551/jat.43075
   Okamoto S, 2019, ANN EPIDEMIOL, V33, P64, DOI 10.1016/j.annepidem.2019.02.003
   Poorabdian S, 2013, INT J OCCUP MED ENV, V26, P555, DOI 10.2478/s13382-013-0127-x
   Rader DJ, 2014, LANCET, V384, P618, DOI 10.1016/S0140-6736(14)61217-4
   Shin HY, 2016, SLEEP MED, V23, P119, DOI 10.1016/j.sleep.2016.05.012
   Smiley A, 2019, J DIABETES METAB DIS, V18, P315, DOI 10.1007/s40200-019-00415-0
   Song QF, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-01363-y
   Svensson T, 2019, J PSYCHOSOM RES, V126, DOI 10.1016/j.jpsychores.2019.109822
   Svensson T, 2019, TRANSL PSYCHIAT, V9, DOI 10.1038/s41398-018-0336-y
   Syauqy A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081848
   The Japanese Institute for Labour Policy and Training, 2019, DAT INT LAB STAT, P248
   Tsuboi H, 2006, J AFFECT DISORDERS, V91, P63, DOI 10.1016/j.jad.2005.12.010
   Tsutsumi A, 2018, J OCCUP HEALTH, V60, P55, DOI 10.1539/joh.17-0161-OA
   World Health Organization, 2021, Noncommunicable diseases
   Xu X, 2018, INT J OBESITY, V42, P794, DOI 10.1038/ijo.2017.223
NR 38
TC 2
Z9 2
U1 0
U2 14
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1341-9145
EI 1348-9585
J9 J OCCUP HEALTH
JI J. Occup. Health
PD JAN
PY 2021
VL 63
IS 1
AR e12275
DI 10.1002/1348-9585.12275
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA WK7SW
UT WOS:000709924200001
PM 34679211
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wolf, EJ
   Morrison, FG
   Sullivan, DR
   Logue, MW
   Guetta, RE
   Stone, A
   Schichman, SA
   McGlinchey, RE
   Milberg, WP
   Miller, MW
AF Wolf, Erika J.
   Morrison, Filomene G.
   Sullivan, Danielle R.
   Logue, Mark W.
   Guetta, Rachel E.
   Stone, Annjanette
   Schichman, Steven A.
   McGlinchey, Regina E.
   Milberg, William P.
   Miller, Mark W.
TI The goddess who spins the thread of life: Klotho, psychiatric stress,
   and accelerated aging
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
ID METHYLATION AGE ASSOCIATIONS; LEUKOCYTE TELOMERE LENGTH; DNA
   METHYLATION; METABOLIC SYNDROME; EPIGENETIC AGE; CEREBROSPINAL-FLUID;
   FUNCTIONAL VARIANT; OXIDATIVE STRESS; TRAUMA EXPOSURE; GENE-EXPRESSION
AB Background: Longevity gene klotho (KL) is associated with age-related phenotypes but has not been evaluated against a direct human biomarker of cellular aging. We examined KL and psychiatric stress, including posttraumatic stress disorder (PTSD), which is thought to potentiate accelerated aging, in association with biomarkers of cellular aging.
   Methods: The sample comprised 309 white, non-Hispanic genotyped veterans with measures of epigenetic age (DNA methylation age), telomere length (n = 252), inflammation (C-reactive protein), psychiatric symptoms, metabolic function, and white matter neural integrity (diffusion tensor imaging; n = 185). Genotyping and DNA methylation were obtained on epi/genome-wide beadchips.
   Results: In gene by environment analyses, two KL variants (rs9315202 and rs9563121) interacted with PTSD severity (peak corrected p = 0.044) and sleep disturbance (peak corrected p = 0.034) to predict advanced epigenetic age. KL variant, rs398655, interacted with self-reported pain in association with slowed epigenetic age (corrected p = 0.048). A well-studied protective variant, rs9527025, was associated with slowed epigenetic age (p = 0.046). The peak PTSD interaction term (with rs9315202) also predicted C-reactive protein (p = 0.049), and white matter microstructural integrity in two tracts (corrected ps = 0.005 - 0.035). This SNP evidenced a main effect with an index of metabolic syndrome severity (p = 0.015). Effects were generally accentuated in older subjects.
   Conclusions: Rs9315202 predicted multiple biomarkers of cellular aging such that psychiatric stress was more strongly associated with cellular aging in those with the minor allele. KL genotype may contribute to a synchronized pathological aging response to stress and could be a therapeutic target to alter the pace of cellular aging.
C1 [Wolf, Erika J.; Morrison, Filomene G.; Sullivan, Danielle R.; Logue, Mark W.; Guetta, Rachel E.; Miller, Mark W.] VA Boston Healthcare Syst, Natl Ctr PTSD, 150 South Huntington Ave, Boston, MA 02130 USA.
   [Wolf, Erika J.; Morrison, Filomene G.; Sullivan, Danielle R.; Logue, Mark W.; Miller, Mark W.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02215 USA.
   [Logue, Mark W.] Boston Univ, Sch Med, Dept Med, Biomed Genet, Boston, MA 02215 USA.
   [Logue, Mark W.] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.
   [Stone, Annjanette; Schichman, Steven A.] Cent Arkansas Vet Healthcare Syst, Pharmacogenom Anal Lab, Res Serv, Little Rock, AR USA.
   [McGlinchey, Regina E.; Milberg, William P.] VA Boston Healthcare Syst, Geriatr Res Educ & Clin Ctr, Boston, MA USA.
   [McGlinchey, Regina E.; Milberg, William P.] VA Boston Healthcare Syst, Translat Res Ctr TBI & Stress Disorders, Boston, MA USA.
   [McGlinchey, Regina E.; Milberg, William P.] Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; Boston University; Boston University; Boston
   University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Central Arkansas Veterans Healthcare System;
   Geriatric Research Education & Clinical Center; Harvard University;
   Harvard University Medical Affiliates; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); VA Boston Healthcare
   System; Harvard University; Harvard University Medical Affiliates; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   Boston Healthcare System; Harvard University; Harvard Medical School
RP Wolf, EJ (corresponding author), VA Boston Healthcare Syst, Natl Ctr PTSD, 150 South Huntington Ave, Boston, MA 02130 USA.
EM Erika.Wolf@va.gov
RI ; Miller, Mark/G-7322-2011
OI Guetta, Rachel/0000-0002-7271-9917; Sullivan, Danielle
   R./0000-0002-0141-5887; Miller, Mark/0000-0001-6393-8563; Wolf,
   Erika/0000-0003-2666-2435
FU National Institute on Aging [R03AG051877]; United States (U.S.)
   Department of Veterans Affairs Clinical Sciences R&D (CSRD) Service
   Merit Review Award [I01 CX-001276-01]; National Institute of Mental
   Health [5T32MH019836-18, R21MH102834]; VA CSR&D Career Development Award
   [1 IK2 CX001772-01]; VA BLRD Merit Award [1I01BX003477-01]; Presidential
   Early Career Award for Scientists and Engineers (PECASE 2013A);
   Translational Research Center for TBI and Stress Disorders (TRACTS), a
   VA Rehabilitation Research and Development Traumatic Brain Injury Center
   of Excellence [B9254-C]; Cooperative Studies Program, Department of
   Veterans Affairs
FX This work was supported by the National Institute on Aging [grant number
   R03AG051877 (EJW)], United States (U.S.) Department of Veterans Affairs
   Clinical Sciences R&D (CSRD) Service Merit Review Award [grant number
   I01 CX-001276-01 (EJW)], National Institute of Mental Health [grant
   number 5T32MH019836-18 (FGM)], National Institute of Mental Health
   [grant number R21MH102834 (MWM), VA CSR&D Career Development Award
   [grant number 1 IK2 CX001772-01 (DRS)], and VA BLR&D Merit Award [grant
   number 1I01BX003477-01 (MWL)]. This work was also supported by a
   Presidential Early Career Award for Scientists and Engineers (PECASE
   2013A) to EJW, as administered by U.S. Department of Veterans Affairs
   Office of Research and Development and by the Translational Research
   Center for TBI and Stress Disorders (TRACTS), a VA Rehabilitation
   Research and Development Traumatic Brain Injury Center of Excellence
   (B9254-C), and the Cooperative Studies Program, Department of Veterans
   Affairs. This research is the result of work supported with resources
   and the use of facilities at the Pharmacogenomics Analysis Laboratory,
   Research and Development Service, Central Arkansas Veterans Healthcare
   System, Little Rock, Arkansas, and the National Center for PTSD. The
   contents of this manuscript do not represent the views of the U.S.
   Department of Veterans Affairs, the National Institutes of Health, or
   the United States Government.
CR Aleagha MSE, 2015, J NEUROIMMUNOL, V281, P5, DOI 10.1016/j.jneuroim.2015.02.004
   Arking DE, 2005, CIRC RES, V96, P412, DOI 10.1161/01.RES.0000157171.04054.30
   Arking DE, 2003, AM J HUM GENET, V72, P1154, DOI 10.1086/375035
   Arking DE, 2002, P NATL ACAD SCI USA, V99, P856, DOI 10.1073/pnas.022484299
   Aryee MJ, 2014, BIOINFORMATICS, V30, P1363, DOI 10.1093/bioinformatics/btu049
   Baylis Daniel, 2013, Longev Healthspan, V2, P8, DOI 10.1186/2046-2395-2-8
   BLAKE DD, 1995, J TRAUMA STRESS, V8, P75, DOI 10.1007/BF02105408
   Boks MP, 2015, PSYCHONEUROENDOCRINO, V51, P506, DOI 10.1016/j.psyneuen.2014.07.011
   Brody GH, 2016, PSYCHOL SCI, V27, P530, DOI 10.1177/0956797615626703
   Bubb EJ, 2018, NEUROSCI BIOBEHAV R, V92, P104, DOI 10.1016/j.neubiorev.2018.05.008
   Buysse D J, 1989, Psychiatry Res, V28, P193
   Campisi J, 2007, NAT REV MOL CELL BIO, V8, P729, DOI 10.1038/nrm2233
   Carroll JE, 2016, SLEEP, V39, P559, DOI 10.5665/sleep.5526
   Cawthon RM, 2002, NUCLEIC ACIDS RES, V30, DOI 10.1093/nar/30.10.e47
   Chen BH, 2016, AGING-US, V8, P1844, DOI 10.18632/aging.101020
   Chen CY, 2013, BIOINFORMATICS, V29, P1399, DOI 10.1093/bioinformatics/btt144
   Chen CD, 2018, J MOL NEUROSCI, V64, P175, DOI 10.1007/s12031-017-1011-0
   Chen CD, 2013, J NEUROSCI, V33, P1927, DOI 10.1523/JNEUROSCI.2080-12.2013
   Crasto CL, 2012, REJUV RES, V15, P295, DOI 10.1089/rej.2011.1268
   Daniels JK, 2013, DEPRESS ANXIETY, V30, P207, DOI 10.1002/da.22044
   Di Bona D, 2014, REJUV RES, V17, P212, DOI 10.1089/rej.2013.1523
   Drew DA, 2017, J AM SOC NEPHROL, V28, P1859, DOI 10.1681/ASN.2016080828
   Dubal DB, 2015, J NEUROSCI, V35, P2358, DOI 10.1523/JNEUROSCI.5791-12.2015
   Dubal DB, 2014, CELL REP, V7, P1065, DOI 10.1016/j.celrep.2014.03.076
   Dubois T, 2018, PSYCHIAT DANUB, V30, P447
   Duce JA, 2008, GLIA, V56, P106, DOI 10.1002/glia.20593
   Epel ES, 2018, ANNU REV CLIN PSYCHO, V14, P371, DOI [10.1146/annurev-clinpsy-032816-045054, 10.1146/annurev-clinpsy-032816045054]
   First M. B., 1997, Structured Clinical Interview for DSM-IV Axis I Disorders, Research Version, Patient Edition
   Fortin JP, 2017, BIOINFORMATICS, V33, P558, DOI 10.1093/bioinformatics/btw691
   Gao X, 2016, ONCOTARGET, V7, P46878, DOI 10.18632/oncotarget.9795
   Glaus J, 2018, DEPRESS ANXIETY, V35, P360, DOI 10.1002/da.22710
   Hamilton E., 2017, Mythology: timeless tales of gods and heroes
   Han LKM, 2018, AM J PSYCHIAT, V175, P774, DOI 10.1176/appi.ajp.2018.17060595
   Horvath S, 2013, GENOME BIOL, V14, DOI 10.1186/gb-2013-14-10-r115
   Hui HP, 2017, ONCOTARGET, V8, P15663, DOI 10.18632/oncotarget.14933
   Irvin MR, 2018, CLIN EPIGENETICS, V10, DOI 10.1186/s13148-018-0481-4
   Jovanovic T, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-09235-9
   Karami M, 2017, J NEUROL SCI, V381, P305, DOI 10.1016/j.jns.2017.09.012
   Kenyon CJ, 2010, NATURE, V464, P504, DOI 10.1038/nature08980
   King GD, 2012, AGE, V34, P1405, DOI 10.1007/s11357-011-9315-4
   Kubany ES, 2000, PSYCHOL ASSESSMENT, V12, P210, DOI 10.1037//1040-3590.12.2.210
   Kuroo M, 1997, NATURE, V390, P45, DOI 10.1038/36285
   Kurosu H, 2006, J BIOL CHEM, V281, P6120, DOI 10.1074/jbc.C500457200
   Kurosu H, 2005, SCIENCE, V309, P1829, DOI 10.1126/science.1112766
   Leon J, 2017, CELL REP, V20, P1360, DOI 10.1016/j.celrep.2017.07.024
   Levine ME, 2015, AGING-US, V7, P1198, DOI 10.18632/aging.100864
   Lindqvist D, 2015, NEUROSCI BIOBEHAV R, V55, P333, DOI 10.1016/j.neubiorev.2015.05.007
   Liu HJ, 2007, SCIENCE, V317, P803, DOI 10.1126/science.1143578
   Logue MW, 2015, NEUROPSYCHOPHARMACOL, V40, P2287, DOI 10.1038/npp.2015.118
   López-Otín C, 2016, CELL, V166, P802, DOI 10.1016/j.cell.2016.07.031
   Maekawa Y, 2009, ENDOCRINE, V35, P341, DOI 10.1007/s12020-009-9181-3
   Majumdar V, 2011, CLIN CHIM ACTA, V412, P1116, DOI 10.1016/j.cca.2011.02.034
   Majumdar V, 2010, BIOCHEM BIOPH RES CO, V403, P412, DOI 10.1016/j.bbrc.2010.11.045
   Massó A, 2018, MOL PSYCHIATR, V23, DOI 10.1038/mp.2017.211
   McEwen BS, 2010, METABOLISM, V59, pS9, DOI 10.1016/j.metabol.2010.07.012
   McGlinchey RE, 2017, INT J METH PSYCH RES, V26, DOI 10.1002/mpr.1556
   MELZACK R, 1987, PAIN, V30, P191, DOI 10.1016/0304-3959(87)91074-8
   Mengel-From J, 2016, J GERONTOL A-BIOL, V71, P1151, DOI 10.1093/gerona/glv163
   Michopoulos V, 2017, NEUROPSYCHOPHARMACOL, V42, P254, DOI 10.1038/npp.2016.146
   Michopoulos V, 2015, AM J PSYCHIAT, V172, P353, DOI 10.1176/appi.ajp.2014.14020263
   Mielke MM, 2012, ALZHEIMERS DEMENT, V8, P105, DOI 10.1016/j.jalz.2011.05.2416
   Miller MW, 2018, BRAIN BEHAV IMMUN, V67, P194, DOI 10.1016/j.bbi.2017.08.022
   Miller MW, 2015, PSYCHONEUROENDOCRINO, V62, P359, DOI 10.1016/j.psyneuen.2015.09.003
   Müezzinler A, 2013, AGEING RES REV, V12, P509, DOI 10.1016/j.arr.2013.01.003
   Muthen B. O., 1998, MPLUS USERS GUIDE
   Nagai R, 2000, CELL MOL LIFE SCI, V57, P738, DOI 10.1007/s000180050038
   Nevalainen T, 2017, CLIN EPIGENETICS, V9, DOI 10.1186/s13148-016-0301-7
   Pitman RK, 2012, NAT REV NEUROSCI, V13, P769, DOI 10.1038/nrn3339
   Plana-Ripoll O, 2019, JAMA PSYCHIAT, V76, P259, DOI 10.1001/jamapsychiatry.2018.3658
   Prather AA, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.81
   Quach A, 2017, AGING-US, V9, P419, DOI 10.18632/aging.101168
   Revelas M, 2018, MECH AGEING DEV, V175, P24, DOI 10.1016/j.mad.2018.06.002
   Révész D, 2018, J CLIN ENDOCR METAB, V103, P148, DOI 10.1210/jc.2017-01625
   Saito Y, 1998, BIOCHEM BIOPH RES CO, V248, P324, DOI 10.1006/bbrc.1998.8943
   Salat DH, 2005, ANN NY ACAD SCI, V1064, P37, DOI 10.1196/annals.1340.009
   Semba RD, 2014, NEUROSCI LETT, V558, P37, DOI 10.1016/j.neulet.2013.10.058
   Semba RD, 2011, J AM GERIATR SOC, V59, P1596, DOI 10.1111/j.1532-5415.2011.03558.x
   Semba RD, 2011, J GERONTOL A-BIOL, V66, P794, DOI 10.1093/gerona/glr058
   Shardell M., 2017, BIOL SCI MED SCI J A, DOI [10.1093/gerona/g1x202, DOI 10.1093/GERONA/G1X202]
   Shardell M, 2016, J GERONTOL A-BIOL, V71, P677, DOI 10.1093/gerona/glv140
   Shiozaki M, 2008, NEUROSCIENCE, V152, P924, DOI 10.1016/j.neuroscience.2008.01.032
   Slade T, 2006, PSYCHOL MED, V36, P1593, DOI 10.1017/S0033291706008452
   Smith SM, 2006, NEUROIMAGE, V31, P1487, DOI 10.1016/j.neuroimage.2006.02.024
   Soerensen M, 2012, EXP GERONTOL, V47, P379, DOI 10.1016/j.exger.2012.02.010
   Ullah A, 2018, INT CONF IMAG PROC, P1
   Wolf EJ, 2016, PSYCHOL MED, V46, P2215, DOI 10.1017/S0033291716000817
   Wolf EJ, 2019, PSYCHOL MED, V49, P791, DOI 10.1017/S0033291718001411
   Wolf EJ, 2018, PSYCHONEUROENDOCRINO, V92, P123, DOI 10.1016/j.psyneuen.2017.12.007
   Wolf EJ, 2018, PSYCHOSOM MED, V80, P42, DOI 10.1097/PSY.0000000000000506
   Wolf EJ, 2016, BIOL PSYCHIAT, V80, P363, DOI 10.1016/j.biopsych.2015.11.023
   Wolf EJ, 2016, PSYCHONEUROENDOCRINO, V63, P155, DOI 10.1016/j.psyneuen.2015.09.020
   Wulff K, 2010, NAT REV NEUROSCI, V11, P589, DOI 10.1038/nrn2868
   Yamamoto M, 2005, J BIOL CHEM, V280, P38029, DOI 10.1074/jbc.M509039200
   Yokoyama JS, 2017, BRAIN IMAGING BEHAV, V11, P391, DOI 10.1007/s11682-016-9598-2
   Yokoyama JS, 2015, ANN CLIN TRANSL NEUR, V2, P215, DOI 10.1002/acn3.161
   Yun YR, 2010, J TISSUE ENG, V1, DOI 10.4061/2010/218142
   Zannas AS, 2015, GENOME BIOL, V16, DOI 10.1186/s13059-015-0828-5
   Zeldich E, 2015, J MOL NEUROSCI, V57, P185, DOI 10.1007/s12031-015-0598-2
   Zeldich E, 2014, J BIOL CHEM, V289, P24700, DOI 10.1074/jbc.M114.567321
NR 99
TC 31
Z9 33
U1 0
U2 6
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD AUG
PY 2019
VL 80
BP 193
EP 203
DI 10.1016/j.bbi.2019.03.007
PG 11
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA IM6LX
UT WOS:000478105500020
PM 30872092
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Horn, P
   Newsome, PN
AF Horn, Paul
   Newsome, Phlip N.
TI Emerging therapeutic targets for NASH: key innovations at the
   preclinical level
SO EXPERT OPINION ON THERAPEUTIC TARGETS
LA English
DT Review
DE Bone-morphogenetic proteins; endoplasmic reticulum stress; inflammasome;
   lipid metabolism; nonalcoholic fatty liver disease; nonalcoholic
   steatohepatitis; platelets; pyroptosis; treatment
ID COA CARBOXYLASE INHIBITION; REDUCES HEPATIC STEATOSIS; DE-NOVO
   LIPOGENESIS; NONALCOHOLIC STEATOHEPATITIS; ER STRESS;
   LIVER-REGENERATION; INFLAMMASOME ACTIVATION; GLUCOSE-METABOLISM;
   INSULIN-RESISTANCE; UP-REGULATION
AB Introduction: nonalcoholic steatohepatitis (NASH) is a globally emerging health problem, mainly caused by increasing trends in the prevalence of obesity and metabolic syndrome. Patients with NASH are mainly affected by cardiovascular risk and extrahepatic cancer, but a significant proportion of patients will develop advanced liver disease, eventually resulting in liver failure or hepatocellular carcinoma. Recent research has yielded a better understanding of the underlying mechanisms and potential targetability for drug development. Areas covered: This review focuses on the role of fructose metabolism, de novo lipogenesis (DNL), endoplasmic reticulum (ER) stress, NLRP3 inflammasome, bone morphogenetic protein (BMP) signaling and platelets in the pathophysiology of NASH. We discuss the suitability of these substrates for targeting liver disease as well as cardiovascular health in patients with NASH. A non-systematic literature search was performed on PubMed and ClinicalTrials.gov. Expert opinion: Targeting fructose metabolism, DNL, ER stress, NLRP3 inflammasome, BMP signaling and platelets are promising therapeutic strategies, warranting further preclinical and clinical investigation. The discussed approaches might not only benefit liver-related outcomes but improve cardiovascular disease as well. Amidst the euphoria of advances in drug development for NASH, parallel endeavors need to address the underlying causes of obesity and metabolic syndrome to prevent NASH.
C1 [Horn, Paul; Newsome, Phlip N.] Univ Hosp Birmingham NHS Fdn Trust, Natl Inst Hlth Res Birmingham Biomed Res Ctr, Birmingham, W Midlands, England.
   [Horn, Paul; Newsome, Phlip N.] Univ Birmingham, Birmingham, W Midlands, England.
   [Horn, Paul; Newsome, Phlip N.] Univ Birmingham, Inst Immunol & Immunotherapy, Ctr Liver & Gastrointestinal Res, Birmingham, W Midlands, England.
   [Horn, Paul; Newsome, Phlip N.] Univ Hosp Birmingham NHS Fdn Trust, Liver Unit, Birmingham, W Midlands, England.
C3 University of Birmingham; University of Birmingham; University of
   Birmingham; University of Birmingham
RP Newsome, PN (corresponding author), Univ Birmingham, Ctr Liver & Gastrointestinal Res, Birmingham B15 2TT, W Midlands, England.; Newsome, PN (corresponding author), Univ Birmingham, Inst Immunol & Immunotherapy, Hepatol, Birmingham B15 2TT, W Midlands, England.
EM p.n.newsome@bham.ac.uk
RI Horn, Paul/O-6885-2015; Newsome, Philip/D-4495-2018
OI Horn, Paul/0000-0002-8755-7703; Newsome, Philip/0000-0001-6085-3652
FU University Hospitals Birmingham NHS Foundation Trust [BRC-1215-20009]
FX The work of the authors has received funding from University Hospitals
   Birmingham NHS Foundation Trust grant [BRC-1215-20009].
CR Abdelmalek MF, 2010, HEPATOLOGY, V51, P1961, DOI 10.1002/hep.23535
   Abeles RD, 2019, ALIMENT PHARM THER, V49, P1077, DOI 10.1111/apt.15192
   Aboyans V, 2018, EUR HEART J, V39, P763, DOI 10.1093/eurheartj/ehx095
   Ameer F, 2014, METABOLISM, V63, P895, DOI 10.1016/j.metabol.2014.04.003
   Angulo P, 2015, GASTROENTEROLOGY, V149, P389, DOI 10.1053/j.gastro.2015.04.043
   Arab JP, 2018, ANNU REV PATHOL-MECH, V13, P321, DOI 10.1146/annurev-pathol-020117-043617
   Arndt S, 2015, GUT, V64, P973, DOI 10.1136/gutjnl-2014-306968
   Aryal B, 2018, EXPERT REV GASTROENT, V12, P1219, DOI 10.1080/17474124.2018.1533813
   Ballantyne CM, 2013, J AM COLL CARDIOL, V62, P1154, DOI 10.1016/j.jacc.2013.05.050
   BARON SH, 1982, DIABETES CARE, V5, P64, DOI 10.2337/diacare.5.1.64
   Bier E, 2015, SCIENCE, V348, DOI 10.1126/science.aaa5838
   Blázquez-Medela AM, 2019, OBES REV, V20, P648, DOI 10.1111/obr.12822
   Breitkopf-Heinlein K, 2017, GUT, V66, P939, DOI 10.1136/gutjnl-2016-313314
   Caballero F, 2009, J HEPATOL, V50, P789, DOI 10.1016/j.jhep.2008.12.016
   Calle R, 2019, J HEPATOL, V70, pE69, DOI 10.1016/S0618-8278(19)30122-7
   Chauhan A, 2016, HEPATOLOGY, V64, P1774, DOI 10.1002/hep.28526
   Choi TY, 2017, HEPATOLOGY, V66, P1616, DOI 10.1002/hep.29309
   Csak T, 2011, HEPATOLOGY, V54, P133, DOI 10.1002/hep.24341
   Dabbagh K, 2018, J HEPATOL, V68, pS60, DOI 10.1016/S0168-8278(18)30341-6
   Day EA, 2017, TRENDS ENDOCRIN MET, V28, P545, DOI 10.1016/j.tem.2017.05.004
   Desroches-Castan A, 2019, HEPATOLOGY, V70, P1392, DOI 10.1002/hep.30655
   Do N, 2012, AM J PHYSIOL-GASTR L, V303, pG1220, DOI 10.1152/ajpgi.00105.2012
   Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI23621
   EASL, 2016, OBESITY FACTS, V9, P65, DOI [10.1159/000443344, 10.1007/s00125-016-3902-y, 10.1016/j.jhep.2015.11.004]
   Esquejo RM, 2018, EBIOMEDICINE, V31, P122, DOI 10.1016/j.ebiom.2018.04.009
   Ezzati M, 2017, LANCET, V390, P2627, DOI [10.1016/S0140-6736(17)32129-3, 10.1016/s0140-6736(17)32129-3]
   Fan JG, 2006, J CELL PHYSIOL, V207, P499, DOI 10.1002/jcp.20593
   *FDA, 2018, NONC NON STEAT LIV F
   Feaver RE, 2016, JCI INSIGHT, V1, DOI 10.1172/jci.insight.90954
   Fujita K, 2008, GUT, V57, P1583, DOI 10.1136/gut.2007.144550
   Gao YM, 2020, AM J ROENTGENOL, V214, P738, DOI 10.2214/AJR.19.21197
   Haneklaus M, 2015, IMMUNOL REV, V265, P53, DOI 10.1111/imr.12285
   Harriman G, 2016, P NATL ACAD SCI USA, V113, pE1796, DOI 10.1073/pnas.1520686113
   Henao-Mejia J, 2012, NATURE, V482, P179, DOI 10.1038/nature10809
   Herrera B, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19010039
   Hundal RS, 2002, J CLIN INVEST, V109, P1321, DOI 10.1172/JCI200214955
   Jensen T, 2018, J HEPATOL, V68, P1063, DOI 10.1016/j.jhep.2018.01.019
   Khan RS, 2019, HEPATOLOGY, V70, P711, DOI 10.1002/hep.30429
   Khanova E, 2018, HEPATOLOGY, V67, P1737, DOI 10.1002/hep.29645
   Kim CW, 2017, CELL METAB, V26, P394, DOI 10.1016/j.cmet.2017.07.009
   Kim JY, 2018, CELL, V175, P133, DOI 10.1016/j.cell.2018.08.020
   Kinoshita K, 2007, GUT, V56, P706, DOI 10.1136/gut.2006.092460
   Kirschbaum M, 2017, LIVER INT, V37, P1731, DOI 10.1111/liv.13386
   Knuuti J, 2020, EUR HEART J, V41, P407, DOI 10.1093/eurheartj/ehz425
   Konerman MA, 2018, J HEPATOL, V68, P362, DOI 10.1016/j.jhep.2017.10.015
   Kotronen A, 2007, J CLIN ENDOCR METAB, V92, P3490, DOI 10.1210/jc.2007-0482
   Krumschnabel G, 2009, CELL DEATH DIFFER, V16, P195, DOI 10.1038/cdd.2008.170
   Lally JSV, 2019, CELL METAB, V29, P174, DOI 10.1016/j.cmet.2018.08.020
   Lalor PF, 2013, AM J PHYSIOL-GASTR L, V304, pG469, DOI 10.1152/ajpgi.00407.2012
   Lawitz EJ, 2018, CLIN GASTROENTEROL H, V16, P1983, DOI 10.1016/j.cgh.2018.04.042
   Lebeaupin C, 2018, J HEPATOL, V69, P927, DOI 10.1016/j.jhep.2018.06.008
   Lebeaupin C, 2018, HEPATOLOGY, V68, P515, DOI 10.1002/hep.29847
   Lesurtel M, 2006, SCIENCE, V312, P104, DOI 10.1126/science.1123842
   Lim JS, 2010, NAT REV GASTRO HEPAT, V7, P251, DOI 10.1038/nrgastro.2010.41
   Loomba R, 2018, GASTROENTEROLOGY, V155, P1463, DOI 10.1053/j.gastro.2018.07.027
   Malehmir M, 2019, NAT MED, V25, P641, DOI 10.1038/s41591-019-0379-5
   Man SM, 2017, IMMUNOL REV, V277, P61, DOI 10.1111/imr.12534
   Mangan MSJ, 2018, NAT REV DRUG DISCOV, V17, P588, DOI [10.1038/nrd.2018.97, 10.1038/nrd.2018.149]
   Marra F, 2018, J HEPATOL, V68, P280, DOI 10.1016/j.jhep.2017.11.014
   Miller CO, 2018, AM J PHYSIOL-ENDOC M, V315, pE386, DOI 10.1152/ajpendo.00027.2018
   Morrell NW, 2016, NAT REV CARDIOL, V13, P106, DOI 10.1038/nrcardio.2015.156
   Mridha AR, 2017, J HEPATOL, V66, P1037, DOI 10.1016/j.jhep.2017.01.022
   Mullard A, 2019, NAT REV DRUG DISCOV, V18, P3
   Muñoz-Félix JM, 2015, PHARMACOL THERAPEUT, V156, P44, DOI 10.1016/j.pharmthera.2015.10.003
   Nakano Y, 2008, J SURG RES, V149, P192, DOI 10.1016/j.jss.2007.09.016
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Olsayszky V, 2017, GENE, V627, P491, DOI 10.1016/j.gene.2017.06.051
   Olsson AK, 2018, PLATELETS, V29, P569, DOI 10.1080/09537104.2018.1453059
   Ouchi R, 2019, CELL METAB, V30, P374, DOI 10.1016/j.cmet.2019.05.007
   Ozhan H, 2010, PLATELETS, V21, P29, DOI 10.3109/09537100903391023
   Palma E, 2019, HEPATOL INT, V13, P51, DOI 10.1007/s12072-018-9913-7
   Petersen MC, 2017, NAT REV ENDOCRINOL, V13, P572, DOI 10.1038/nrendo.2017.80
   Pockros PJ, 2019, LIVER INT, V39, P2082, DOI 10.1111/liv.14209
   Qiu SQ, 2017, CELL DEATH DIFFER, V24, P588, DOI 10.1038/cdd.2017.24
   Ribera J, 2017, AM J PHYSIOL-GASTR L, V313, pG492, DOI 10.1152/ajpgi.00428.2016
   Ridker PM, 2017, NEW ENGL J MED, V377, P1119, DOI 10.1056/NEJMoa1707914
   ROSEN V, 1989, CONNECT TISSUE RES, V20, P313, DOI 10.3109/03008208909023902
   Rowe IA, 2014, HEPATOLOGY, V59, P375, DOI 10.1002/hep.26571
   Saini S, 2015, ENDOCRINE, V48, P405, DOI 10.1007/s12020-014-0406-8
   Sanders FWB, 2016, BIOL REV, V91, P452, DOI 10.1111/brv.12178
   Sandow JJ, 2014, CELL DEATH DIFFER, V21, P475, DOI 10.1038/cdd.2013.168
   Scull CM, 2010, J INFLAMM-LOND, V7, DOI 10.1186/1476-9255-7-53
   Shan B, 2017, NAT IMMUNOL, V18, P519, DOI 10.1038/ni.3709
   Siddiqui MS, 2020, J HEPATOL, V72, P25, DOI 10.1016/j.jhep.2019.10.006
   Skubic C, 2018, EXPERT OPIN DRUG MET, V14, P831, DOI 10.1080/17425255.2018.1492552
   Softic S, 2019, CELL METAB, V30, P735, DOI 10.1016/j.cmet.2019.09.003
   Softic S, 2017, J CLIN INVEST, V127, P4059, DOI 10.1172/JCI94585
   Stiede K, 2017, HEPATOLOGY, V66, P324, DOI 10.1002/hep.29246
   Sugimoto H, 2007, FASEB J, V21, P256, DOI 10.1096/fj.06-6837com
   Swanson KV, 2019, NAT REV IMMUNOL, V19, P477, DOI 10.1038/s41577-019-0165-0
   Szabo G, 2015, NAT REV GASTRO HEPAT, V12, P387, DOI 10.1038/nrgastro.2015.94
   Tacke F, 2017, J HEPATOL, V66, P1300, DOI 10.1016/j.jhep.2017.02.026
   Takahashi K, 2013, SURG TODAY, V43, P1081, DOI 10.1007/s00595-012-0418-z
   Tran C, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040356
   Tufanli O, 2017, P NATL ACAD SCI USA, V114, pE1395, DOI 10.1073/pnas.1621188114
   Upton JP, 2012, SCIENCE, V338, P818, DOI 10.1126/science.1226191
   van der Meijden PEJ, 2019, NAT REV CARDIOL, V16, P166, DOI 10.1038/s41569-018-0110-0
   Vilar-Gomez E, 2015, GASTROENTEROLOGY, V149, P367, DOI 10.1053/j.gastro.2015.04.005
   Wang CY, 2019, HEPATOLOGY, V70, P1986, DOI 10.1002/hep.30780
   Wei Q, 2015, LAB INVEST, V95, P804, DOI 10.1038/labinvest.2015.63
   Wolf MJ, 2014, CANCER CELL, V26, P549, DOI 10.1016/j.ccell.2014.09.003
   Wree A, 2014, HEPATOLOGY, V59, P898, DOI 10.1002/hep.26592
   Xu B, 2018, J HEPATOL, V68, P773, DOI 10.1016/j.jhep.2017.11.040
   Yang T, 2012, MOL MED REP, V6, P246, DOI 10.3892/mmr.2012.892
   Younossi Z, 2018, NAT REV GASTRO HEPAT, V15, P11, DOI 10.1038/nrgastro.2017.109
   Younossi ZM, 2019, LANCET, V394, P2184, DOI 10.1016/S0140-6736(19)33041-7
   Younossi ZM, 2015, HEPATOLOGY, V62, p739A, DOI 10.1002/hep.28431
   Yuan MS, 2001, SCIENCE, V293, P1673, DOI 10.1126/science.1061620
   Zeng ZL, 2019, CELL PROLIFERAT, V52, DOI 10.1111/cpr.12563
   Zhang KZ, 2011, EMBO J, V30, P1357, DOI 10.1038/emboj.2011.52
   2019, HEPATOLOGY, V70, P1
NR 111
TC 9
Z9 9
U1 0
U2 18
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1472-8222
EI 1744-7631
J9 EXPERT OPIN THER TAR
JI Expert Opin. Ther. Targets
PD MAR 3
PY 2020
VL 24
IS 3
BP 175
EP 186
DI 10.1080/14728222.2020.1728742
EA FEB 2020
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA KU5VL
UT WOS:000513793600001
PM 32053033
DA 2025-06-11
ER

PT J
AU Castro, JP
   Grune, T
   Speckmann, B
AF Castro, Jose Pedro
   Grune, Tilman
   Speckmann, Bodo
TI The two faces of reactive oxygen species (ROS) in adipocyte function and
   dysfunction
SO BIOLOGICAL CHEMISTRY
LA English
DT Review
DE adipogenesis; adipose tissue dysregulation; antioxidants; metabolic
   disorders; oxidative stress
ID ACTIVATED RECEPTOR-GAMMA; SELENOPROTEIN P EXPRESSION; WHITE
   ADIPOSE-TISSUE; FREE-RADICAL THEORY; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; METABOLIC SYNDROME; OXIDIZED PROTEINS; HYDROGEN-PEROXIDE;
   ANATOMIC SITE
AB White adipose tissue (WAT) is actively involved in the regulation of whole-body energy homeostasis via storage/ release of lipids and adipokine secretion. Current research links WAT dysfunction to the development of metabolic syndrome (MetS) and type 2 diabetes (T2D). The expansion of WAT during oversupply of nutrients prevents ectopic fat accumulation and requires proper preadipocyte-to-adipocyte differentiation. An assumed link between excess levels of reactive oxygen species (ROS), WAT dysfunction and T2D has been discussed controversially. While oxidative stress conditions have conclusively been detected in WAT of T2D patients and related animal models, clinical trials with antioxidants failed to prevent T2D or to improve glucose homeostasis. Furthermore, animal studies yielded inconsistent results regarding the role of oxidative stress in the development of diabetes. Here, we discuss the contribution of ROS to the (patho) physiology of adipocyte function and differentiation, with particular emphasis on sources and nutritional modulators of adipocyte ROS and their functions in signaling mechanisms controlling adipogenesis and functions of mature fat cells. We propose a concept of ROS balance that is required for normal functioning of WAT. We explain how both excessive and diminished levels of ROS, e. g. resulting from over supplementation with antioxidants, contribute to WAT dysfunction and subsequently insulin resistance.
C1 [Castro, Jose Pedro; Grune, Tilman] German Ctr Diabet Res DZD, Ingolstadter Landstr 1, D-85764 Munich, Germany.
   [Castro, Jose Pedro] Univ Porto, Dept Expt Biol, Fac Med, Alameda Prof Hernani Monteiro, P-4200319 Oporto, Portugal.
   [Castro, Jose Pedro] Inst Innovat & Hlth Res, Aging & Stress Grp, R Alfredo Allen, P-4200135 Oporto, Portugal.
   [Grune, Tilman] Univ Potsdam, Inst Nutr Sci, Dept Physiol & Pathophysiol, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany.
   [Grune, Tilman] German Ctr Cardiovasc Res DZHK, Postfach 65 21 33, D-13353 Berlin, Germany.
   [Speckmann, Bodo] German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Toxicol, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany.
C3 German Center for Diabetes Research (DZD); Universidade do Porto;
   University of Potsdam; German Centre for Cardiovascular Research;
   Leibniz Association; Deutsches Institut fur Ernahrungsforschung
   Potsdam-Rehbrucke (DIfE)
RP Castro, JP (corresponding author), German Ctr Diabet Res DZD, Ingolstadter Landstr 1, D-85764 Munich, Germany.; Castro, JP (corresponding author), Univ Porto, Dept Expt Biol, Fac Med, Alameda Prof Hernani Monteiro, P-4200319 Oporto, Portugal.; Castro, JP (corresponding author), Inst Innovat & Hlth Res, Aging & Stress Grp, R Alfredo Allen, P-4200135 Oporto, Portugal.
EM jose.castro@dife.de
OI Grune, Tilman/0000-0003-4775-9973; Castro, Jose
   Pedro/0000-0002-2627-5331
CR Ahima RS, 2009, NAT MED, V15, P996, DOI 10.1038/nm0909-996
   Akbar S., 2011, The British Journal of Diabetes and Vascular Disease, V11, P62
   Anderson EJ, 2009, J CLIN INVEST, V119, P573, DOI 10.1172/JCI37048
   [Anonymous], 2015, OXID MED CELL LONGEV, DOI DOI 10.1155/2015/490613
   Barja G, 2014, PROG MOL BIOL TRANSL, V127, P1, DOI 10.1016/B978-0-12-394625-6.00001-5
   Barroso I, 1999, NATURE, V402, P880, DOI 10.1038/47254
   Bedard K, 2007, PHYSIOL REV, V87, P245, DOI 10.1152/physrev.00044.2005
   Bjelakovic G, 2013, JAMA-J AM MED ASSOC, V310, P1178, DOI 10.1001/jama.2013.277028
   Bollineni RC, 2014, J PROTEOME RES, V13, P5081, DOI 10.1021/pr500324y
   Brand MD, 2010, EXP GERONTOL, V45, P466, DOI 10.1016/j.exger.2010.01.003
   Bremer AA, 2013, J OBES, V2013, DOI 10.1155/2013/393192
   Cancello R, 2005, DIABETES, V54, P2277, DOI 10.2337/diabetes.54.8.2277
   Carnevalli LS, 2010, DEV CELL, V18, P763, DOI 10.1016/j.devcel.2010.02.018
   Carrière A, 2003, FEBS LETT, V550, P163, DOI 10.1016/S0014-5793(03)00862-7
   Castro JP, 2012, FREE RADICAL BIO MED, V53, P916, DOI 10.1016/j.freeradbiomed.2012.06.005
   Chattopadhyay M, 2015, MOL CELL BIOCHEM, V399, P95, DOI 10.1007/s11010-014-2236-7
   Cho SH, 2004, FEBS LETT, V560, P7, DOI 10.1016/S0014-5793(04)00112-7
   Christensen K, 2015, ENVIRON RES, V140, P76, DOI 10.1016/j.envres.2015.03.020
   Cotillard A, 2014, J CLIN ENDOCR METAB, V99, pE1466, DOI 10.1210/jc.2014-1074
   Curtis JM, 2010, DIABETES, V59, P1132, DOI 10.2337/db09-1105
   Czernichow S, 2009, AM J CLIN NUTR, V90, P329, DOI 10.3945/ajcn.2009.27635
   Dalle-Donne I, 2003, TRENDS MOL MED, V9, P169, DOI 10.1016/S1471-4914(03)00031-5
   Dasuri K, 2011, FREE RADICAL BIO MED, V51, P1727, DOI 10.1016/j.freeradbiomed.2011.08.001
   Davies KJA, 2006, NEUROLOGY, V66, pS93, DOI 10.1212/01.wnl.0000192308.43151.63
   De Pauw A, 2009, AM J PATHOL, V175, P927, DOI 10.2353/ajpath.2009.081155
   Díaz-Ruiz A, 2015, ANTIOXID REDOX SIGN, V23, P597, DOI 10.1089/ars.2014.5939
   Dikalov S, 2011, FREE RADICAL BIO MED, V51, P1289, DOI 10.1016/j.freeradbiomed.2011.06.033
   DJIAN P, 1983, J CLIN INVEST, V72, P1200, DOI 10.1172/JCI111075
   Drong AW, 2012, CLIN PHARMACOL THER, V92, P707, DOI 10.1038/clpt.2012.149
   Faghihi T, 2014, AM J THER, V21, P491, DOI 10.1097/MJT.0b013e318269175f
   Findeisen HM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0018532
   Fisher-Wellman KH, 2012, TRENDS ENDOCRIN MET, V23, P142, DOI 10.1016/j.tem.2011.12.008
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Frohnert BI, 2013, ADV NUTR, V4, P157, DOI 10.3945/an.112.003319
   Fujiki K, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3262
   Fujiki K, 2009, BMC BIOL, V7, DOI 10.1186/1741-7007-7-38
   Gagnon A, 2001, J CELL PHYSIOL, V189, P14, DOI 10.1002/jcp.1132
   Gandotra S, 2011, NEW ENGL J MED, V364, P740, DOI 10.1056/NEJMoa1007487
   Goldstein BJ, 2005, DIABETES, V54, P311, DOI 10.2337/diabetes.54.2.311
   Grimsrud PA, 2007, MOL CELL PROTEOMICS, V6, P624, DOI 10.1074/mcp.M600120-MCP200
   GRUNE T, 1995, J BIOL CHEM, V270, P2344, DOI 10.1074/jbc.270.5.2344
   Grune T, 1996, J BIOL CHEM, V271, P15504, DOI 10.1074/jbc.271.26.15504
   Grune T, 2003, BIOCHEM BIOPH RES CO, V305, P709, DOI 10.1016/S0006-291X(03)00809-X
   Grune T, 1997, FASEB J, V11, P526, DOI 10.1096/fasebj.11.7.9212076
   Guilherme A, 2008, NAT REV MOL CELL BIO, V9, P367, DOI 10.1038/nrm2391
   Halliwell B, 2006, PLANT PHYSIOL, V141, P312, DOI 10.1104/pp.106.077073
   Han CY, 2012, J BIOL CHEM, V287, P10379, DOI 10.1074/jbc.M111.304998
   Harman D, 2003, ANTIOXID REDOX SIGN, V5, P557, DOI 10.1089/152308603770310202
   HARMAN D, 1956, J GERONTOL, V11, P298, DOI 10.1093/geronj/11.3.298
   Harman D, 1998, J Int Fed Clin Chem, V10, P24
   Hemming S, 2014, STEM CELLS, V32, P802, DOI 10.1002/stem.1573
   Hensley K, 2000, FREE RADICAL BIO MED, V28, P1456, DOI 10.1016/S0891-5849(00)00252-5
   Höhn A, 2014, FREE RADICAL BIO MED, V71, P70, DOI 10.1016/j.freeradbiomed.2014.02.028
   Höhn A, 2013, J PROTEOMICS, V92, P132, DOI 10.1016/j.jprot.2013.01.004
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Ikeda S, 2001, J NUTR, V131, P2892, DOI 10.1093/jn/131.11.2892
   Ima-Nirwana S, 2004, J MED FOOD, V7, P45, DOI 10.1089/109662004322984699
   Imhoff BR, 2011, CELL MOL BIOL LETT, V16, P149, DOI 10.2478/s11658-010-0042-0
   Iwakami S, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027401
   Jankovic A, 2014, METABOLISM, V63, P661, DOI 10.1016/j.metabol.2014.01.009
   Jung T, 2009, MOL ASPECTS MED, V30, P191, DOI 10.1016/j.mam.2009.04.001
   Kästle M, 2012, FREE RADICAL BIO MED, V53, P1468, DOI 10.1016/j.freeradbiomed.2012.05.039
   Kahn SE, 2006, NATURE, V444, P840, DOI 10.1038/nature05482
   Karagiannides I, 2001, AM J PHYSIOL-REG I, V280, pR1772, DOI 10.1152/ajpregu.2001.280.6.R1772
   Kim CY, 2013, J LIPID RES, V54, P2069, DOI 10.1194/jlr.M034603
   Kim JE, 2004, DIABETES, V53, P2748, DOI 10.2337/diabetes.53.11.2748
   KIRKLAND JL, 1990, AM J PHYSIOL, V258, pC206, DOI 10.1152/ajpcell.1990.258.2.C206
   Kirkland JL, 2002, EXP GERONTOL, V37, P757, DOI 10.1016/S0531-5565(02)00014-1
   KIRKLAND JL, 1994, J GERONTOL, V49, pB31, DOI 10.1093/geronj/49.1.B31
   Konige M, 2014, BBA-MOL BASIS DIS, V1842, P393, DOI 10.1016/j.bbadis.2013.05.007
   KONO T, 1982, J BIOL CHEM, V257, P942
   Lau DCW, 2005, AM J PHYSIOL-HEART C, V288, pH2031, DOI 10.1152/ajpheart.01058.2004
   Le Lay S, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/908539
   LeBlanc SE, 2012, MOL ENDOCRINOL, V26, P583, DOI 10.1210/me.2011-1162
   Lee H, 2009, J BIOL CHEM, V284, P10601, DOI 10.1074/jbc.M808742200
   Lee KH, 2014, MOL CELLS, V37, P734, DOI 10.14348/molcells.2014.0180
   Levine RL, 2001, EXP GERONTOL, V36, P1495, DOI 10.1016/S0531-5565(01)00135-8
   LITTLE SA, 1980, J BIOL CHEM, V255, P888
   Loh K, 2009, CELL METAB, V10, P260, DOI 10.1016/j.cmet.2009.08.009
   Lundgren M, 2007, DIABETOLOGIA, V50, P625, DOI 10.1007/s00125-006-0572-1
   MACKALL JC, 1976, J BIOL CHEM, V251, P6462
   Mahadev K, 2004, MOL CELL BIOL, V24, P1844, DOI 10.1128/MCB.24.5.1844-1854.2004
   Mahadev K, 2001, J BIOL CHEM, V276, P48662, DOI 10.1074/jbc.M105061200
   MAY JM, 1979, J BIOL CHEM, V254, P2214
   Minamino T, 2009, NAT MED, V15, P1082, DOI 10.1038/nm.2014
   Murdolo G, 2013, BIOCHIMIE, V95, P585, DOI 10.1016/j.biochi.2012.12.014
   Myung SK, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f10
   Nilsson E, 2014, DIABETES, V63, P2962, DOI 10.2337/db13-1459
   Nyström T, 2005, EMBO J, V24, P1311, DOI 10.1038/sj.emboj.7600599
   Park HT, 2012, CLIN ENDOCRINOL, V76, P59, DOI 10.1111/j.1365-2265.2011.04141.x
   Peng XD, 2003, GENE DEV, V17, P1352, DOI 10.1101/gad.1089403
   Pietiläinen KH, 2008, PLOS MED, V5, DOI 10.1371/journal.pmed.0050051
   Pittenger MF, 1999, SCIENCE, V284, P143, DOI 10.1126/science.284.5411.143
   Poulos SP, 2010, EXP BIOL MED, V235, P1185, DOI 10.1258/ebm.2010.010063
   Rahman F, 2014, FRONT CELL DEV BIOL, V2, DOI 10.3389/fcell.2014.00029
   Rains JL, 2011, FREE RADICAL BIO MED, V50, P567, DOI 10.1016/j.freeradbiomed.2010.12.006
   Reinheckel T, 1998, BIOCHEM J, V335, P637, DOI 10.1042/bj3350637
   Rigoulet M, 2011, ANTIOXID REDOX SIGN, V14, P459, DOI 10.1089/ars.2010.3363
   Rosen ED, 2006, NAT REV MOL CELL BIO, V7, P885, DOI 10.1038/nrm2066
   Rudich A, 1997, AM J PHYSIOL-ENDOC M, V272, pE935, DOI 10.1152/ajpendo.1997.272.5.E935
   Rydén M, 2004, BIOCHEM BIOPH RES CO, V318, P168, DOI 10.1016/j.bbrc.2004.04.010
   SANDRA A, 1981, AM J PHYSIOL, V241, pE281, DOI 10.1152/ajpendo.1981.241.4.E281
   Scherz-Shouval R, 2007, EMBO J, V26, P1749, DOI 10.1038/sj.emboj.7601623
   Schroeder K, 2009, ARTERIOSCL THROM VAS, V29, P239, DOI 10.1161/ATVBAHA.108.174219
   Siersbæk R, 2011, EMBO J, V30, P1459, DOI 10.1038/emboj.2011.65
   Sies H, 2014, J BIOL CHEM, V289, P8735, DOI 10.1074/jbc.R113.544635
   Sies H, 2015, REDOX BIOL, V4, P180, DOI 10.1016/j.redox.2015.01.002
   Speckmann B, 2014, INFLAMM BOWEL DIS, V20, P1110, DOI 10.1097/MIB.0000000000000020
   Speckmann B, 2008, HEPATOLOGY, V48, P1998, DOI 10.1002/hep.22526
   Stadtman ER, 2000, ANN NY ACAD SCI, V899, P191
   Steinbrenner H, 2013, FREE RADICAL BIO MED, V65, P1538, DOI 10.1016/j.freeradbiomed.2013.07.016
   Steinbrenner H, 2013, ANTIOXID REDOX SIGN, V19, P181, DOI 10.1089/ars.2013.5246
   Steinbrenner H, 2011, J CLIN BIOCHEM NUTR, V48, P40, DOI 10.3164/jcbn.11-002FR
   STERN JS, 1972, LANCET, V2, P948
   Stranges S, 2007, ANN INTERN MED, V147, P217, DOI 10.7326/0003-4819-147-4-200708210-00175
   Takada H, 2014, EPIGENETICS-US, V9, P1195, DOI 10.4161/epi.29856
   Tamori Y, 2002, DIABETES, V51, P2045, DOI 10.2337/diabetes.51.7.2045
   Tchkonia T, 2010, AGING CELL, V9, P667, DOI 10.1111/j.1474-9726.2010.00608.x
   Tormos KV, 2011, CELL METAB, V14, P537, DOI 10.1016/j.cmet.2011.08.007
   Ullrich O, 1999, P NATL ACAD SCI USA, V96, P6223, DOI 10.1073/pnas.96.11.6223
   Um SH, 2004, NATURE, V431, P200, DOI 10.1038/nature02866
   Uto-Kondo H, 2009, J NUTR, V139, P51, DOI 10.3945/jn.108.096131
   Valerio A, 2006, J CLIN INVEST, V116, P2791, DOI [10.1172/JCI28570, 10.1172/JCI28570.]
   Vigouroux C, 2011, INT J BIOCHEM CELL B, V43, P862, DOI 10.1016/j.biocel.2011.03.002
   Virtue S, 2010, BBA-MOL CELL BIOL L, V1801, P338, DOI 10.1016/j.bbalip.2009.12.006
   Wang CH, 2013, FEBS J, V280, P1039, DOI 10.1111/febs.12096
   Wang LF, 2013, EMBO J, V32, P45, DOI 10.1038/emboj.2012.306
   Wang LF, 2010, P NATL ACAD SCI USA, V107, P7317, DOI 10.1073/pnas.1000031107
   Wang T, 2010, OBESITY, V18, P1493, DOI 10.1038/oby.2009.456
   Wei J, 2015, NUTR J, V14, DOI 10.1186/s12937-015-0007-2
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Wu ZD, 1999, MOL CELL, V3, P151, DOI 10.1016/S1097-2765(00)80306-8
   Xu JL, 2012, DIABETES, V61, P3208, DOI 10.2337/db11-1716
   Yin RC, 2013, J AM CHEM SOC, V135, P10396, DOI 10.1021/ja4028346
   Yoo H, 2004, J LIPID RES, V45, P1324, DOI 10.1194/jlr.M400031-JLR200
   Zarrouki B, 2007, FEBS LETT, V581, P2394, DOI 10.1016/j.febslet.2007.04.048
   Zhang DD, 2003, MOL CELL BIOL, V23, P8137, DOI 10.1128/MCB.23.22.8137-8151.2003
   Zhang YY, 2011, AM J PHYSIOL-ENDOC M, V300, pE77, DOI 10.1152/ajpendo.00380.2010
   Zhou J, 2013, FREE RADICAL BIO MED, V65, P1548, DOI 10.1016/j.freeradbiomed.2013.07.012
NR 139
TC 114
Z9 122
U1 1
U2 28
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1431-6730
EI 1437-4315
J9 BIOL CHEM
JI Biol. Chem.
PD AUG
PY 2016
VL 397
IS 8
BP 709
EP 724
DI 10.1515/hsz-2015-0305
PG 16
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DQ9ES
UT WOS:000379513800002
PM 27031218
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Lv, DD
   Han, N
   Yuan, M
   Huang, W
   Yan, LB
   Tang, H
AF Lv, Duoduo
   Han, Ning
   Yuan, Man
   Huang, Wei
   Yan, Libo
   Tang, Hong
TI Depression and the risk of non-alcohol fatty liver disease: Results from
   a cross-sectional study and a Mendelian randomization analysis
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Non-alcohol fatty liver disease; Cross-sectional study;
   NHANES; Mendelian randomization
ID METABOLIC SYNDROME; ASSOCIATION; NAFLD; INFLAMMATION; MANAGEMENT;
   BEHAVIORS; DIAGNOSIS; GUIDANCE
AB Background: Previous studies have suggested that psychiatric factors may be pathogenic for NAFLD. However, the association between depression and NAFLD is not been consistent, and whether depression plays a causal role in the development of NAFLD remains unclear. Methods: We extracted data from the National Health and Nutrition Examination Survey (NHANES) 2017-2018 to assess the correlation between depression and NAFLD risk. Based on previous genome-wide association studies (GWAS) meta-analyses on NAFLD and depression, we performed a Mendelian randomization (MR) analysis to explore the causal effect of depression on NAFLD. The primary analysis method used in the MR analysis was inverse variance weighted. Results: We ultimately extracted the data from 3878 individuals in the NHANES database to perform the crosssectional study. Multivariable-adjusted logistic regression showed that depressed individuals had a higher risk of NAFLD than controls (odds ratio [OR] 1.33, 95 % CI 1.03-1.72, p = 0.027) among women. Based on GWAS data, we included 36 genetic variants as instrumental variables to estimate the causal effect of depression on NAFLD risk. The MR analysis revealed a causal association between genetically predicted depression and an increased risk of NAFLD (OR = 1.504, 95 % CI 1.13-2.00, p = 0.005). Limitations: The consistency of these findings in Eastern populations requires further longitudinal studies. Conclusions: This cross-sectional study suggested that depression might increase the risk of NAFLD in women. The MR analysis demonstrated that there exists a causal association between genetically predicated depression and NAFLD risk.
C1 [Lv, Duoduo; Han, Ning; Yuan, Man; Huang, Wei; Yan, Libo; Tang, Hong] Sichuan Univ, West China Hosp, Ctr Infect Dis, 37 Guoxue Alley, Chengdu 610041, Sichuan, Peoples R China.
   [Lv, Duoduo; Han, Ning; Huang, Wei; Yan, Libo; Tang, Hong] Sichuan Univ, Div Infect Dis, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China.
C3 Sichuan University; Sichuan University
RP Yan, LB; Tang, H (corresponding author), Sichuan Univ, West China Hosp, Ctr Infect Dis, 37 Guoxue Alley, Chengdu 610041, Sichuan, Peoples R China.
EM yanlibo@wchscu.cn; tanghong6198@wchscu.cn
RI Yan, Libo/H-2328-2012; Yuan, Man/KYO-7421-2024
FU National Key Research and Devel-opment Program of China
   [2022YFC2304800]; The 1.3.5 project for disciplines of excellence, West
   China Hospital, Sichuan University [ZYGD23030]; Science and Technology
   project of the Health Commission of Sichuan Province [23009]
FX This work was supported by the National Key Research and Devel-opment
   Program of China (No. 2022YFC2304800) , the 1.3.5 project for
   disciplines of excellence, West China Hospital, Sichuan University (No.
   ZYGD23030) and the Science and Technology project of the Health
   Commission of Sichuan Province (No.23009) .
CR Albert KM, 2019, ANNU REV CLIN PSYCHO, V15, P399, DOI 10.1146/annurev-clinpsy-050718-095557
   Arrese M, 2016, DIGEST DIS SCI, V61, P1294, DOI 10.1007/s10620-016-4049-x
   Balakrishnan M, 2021, CLIN GASTROENTEROL H, V19, P61, DOI 10.1016/j.cgh.2020.04.067
   Bowden J, 2016, GENET EPIDEMIOL, V40, P304, DOI 10.1002/gepi.21965
   Bowden J, 2015, INT J EPIDEMIOL, V44, P512, DOI 10.1093/ije/dyv080
   Burgess S, 2017, EUR J EPIDEMIOL, V32, P377, DOI 10.1007/s10654-017-0255-x
   Burgess S, 2013, GENET EPIDEMIOL, V37, P658, DOI 10.1002/gepi.21758
   Byrne CD, 2024, METAB TARGET ORGAN D, V4, DOI 10.20517/mtod.2024.06
   Byrne CD, 2020, J HEPATOL, V72, P785, DOI 10.1016/j.jhep.2020.01.013
   Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI 10.1002/hep.29367
   Chen DZ, 2023, PSYCHOL MED, V53, P7309, DOI 10.1017/S0033291723000867
   Cho IY, 2021, EPIDEMIOL PSYCH SCI, V30, DOI 10.1017/S204579602000116X
   Choi JM, 2021, FRONT MED-LAUSANNE, V7, DOI 10.3389/fmed.2020.585618
   Colognesi M, 2020, BIOMEDICINES, V8, DOI 10.3390/biomedicines8070229
   Davey Smith G, 2014, HUM MOL GENET, V23, pR89, DOI 10.1093/hmg/ddu328
   Dubovsky SL, 2021, PSYCHOTHER PSYCHOSOM, V90, P160, DOI 10.1159/000511348
   Duell PB, 2022, ARTERIOSCL THROM VAS, V42, pE168, DOI 10.1161/ATV.0000000000000153
   Duseja A, 2023, J CLIN EXP HEPATOL, V13, P273, DOI 10.1016/j.jceh.2022.11.014
   Eddowes PJ, 2019, GASTROENTEROLOGY, V156, P1717, DOI 10.1053/j.gastro.2019.01.042
   Eslam M, 2020, J HEPATOL, V73, P202, DOI 10.1016/j.jhep.2020.03.039
   Farzanegi P, 2019, EUR J SPORT SCI, V19, P994, DOI 10.1080/17461391.2019.1571114
   Ghodsian N, 2021, CELL REP MED, V2, DOI 10.1016/j.xcrm.2021.100437
   Goossens GH, 2021, NAT REV ENDOCRINOL, V17, P47, DOI 10.1038/s41574-020-00431-8
   Gu YP, 2022, J AFFECT DISORDERS, V301, P8, DOI 10.1016/j.jad.2021.12.128
   Hartwig FP, 2017, INT J EPIDEMIOL, V46, P1985, DOI 10.1093/ije/dyx102
   Howard DM, 2019, NAT NEUROSCI, V22, P343, DOI 10.1038/s41593-018-0326-7
   Huang DIQ, 2021, NAT REV GASTRO HEPAT, V18, P223, DOI 10.1038/s41575-020-00381-6
   Kim D, 2019, ALIMENT PHARM THER, V50, P590, DOI 10.1111/apt.15395
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Lazarus JV, 2022, NAT REV GASTRO HEPAT, V19, P60, DOI 10.1038/s41575-021-00523-4
   Li SD, 2024, J AFFECT DISORDERS, V352, P379, DOI 10.1016/j.jad.2024.02.074
   Liu Y, 2017, J AFFECT DISORDERS, V217, P190, DOI 10.1016/j.jad.2017.04.009
   Lonardo A., 2020, Explor Med, V1, P85
   Lonardo A, 2024, J HEPATOL, V80, DOI 10.1016/j.jhep.2024.01.012
   Lonardo A, 2023, EXPERT REV CLIN PHAR, V16, P891, DOI 10.1080/17512433.2023.2259306
   Lonardo A, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21165888
   Lonardo A, 2020, J CLIN MED, V9, DOI 10.3390/jcm9051278
   Lonardo A, 2019, HEPATOLOGY, V70, P1457, DOI 10.1002/hep.30626
   Miller AH, 2009, BIOL PSYCHIAT, V65, P732, DOI 10.1016/j.biopsych.2008.11.029
   Noon SL, 2021, J PEDIATR GASTR NUTR, V72, P579, DOI 10.1097/MPG.0000000000003024
   Parker R, 2019, ALIMENT PHARM THER, V50, P830, DOI 10.1111/apt.15453
   Rinella ME, 2023, J HEPATOL, V79, P1542, DOI 10.1016/j.jhep.2023.06.003
   Shea S, 2024, FRONT ENDOCRINOL, V15, DOI 10.3389/fendo.2024.1357664
   Shea S, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9111697
   Soto-Angona O, 2020, BMC MED, V18, DOI 10.1186/s12916-020-01713-8
   Staley JR, 2016, BIOINFORMATICS, V32, P3207, DOI 10.1093/bioinformatics/btw373
   Targher G, 2021, NAT REV GASTRO HEPAT, V18, P599, DOI 10.1038/s41575-021-00448-y
   Tripathi A, 2018, NAT REV GASTRO HEPAT, V15, P397, DOI 10.1038/s41575-018-0011-z
   Vaváková M, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/898393
   Wainwright P, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17030367
   Wang MH, 2022, J AFFECT DISORDERS, V312, P17, DOI 10.1016/j.jad.2022.06.008
   Winter SE, 2023, P NATL ACAD SCI USA, V120, DOI 10.1073/pnas.2316579120
   Wu WT, 2021, MILITARY MED RES, V8, DOI 10.1186/s40779-021-00338-z
   Xiao JL, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.691696
   Zhang M, 2021, TRANSL PSYCHIAT, V11, DOI 10.1038/s41398-021-01759-z
   Zheng P, 2016, MOL PSYCHIATR, V21, P786, DOI 10.1038/mp.2016.44
NR 56
TC 3
Z9 3
U1 7
U2 20
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD DEC 1
PY 2024
VL 366
BP 300
EP 307
DI 10.1016/j.jad.2024.08.189
EA SEP 2024
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA F7F3K
UT WOS:001311429800001
PM 39216642
DA 2025-06-11
ER

PT J
AU Morales-Avila, UM
   Yahia, EM
   Montalvo-González, R
   Becerra-Verdín, EM
   Montalvo-González, E
AF Mireya Morales-Avila, Ursula
   Yahia, Elhadi M.
   Montalvo-Gonzalez, Ruben
   Mendeleev Becerra-Verdin, Eduardo
   Montalvo-Gonzalez, Efigenia
TI Effect of Low-Fat Diets Enriched with Fruit Purees on the Biochemical
   Markers of Metabolic Syndrome Analogy Induced-Rats
SO INTERNATIONAL JOURNAL OF MORPHOLOGY
LA English
DT Article
DE Biochemical markers; Fruit purees; Hepatoprotective effect; Metabolic
   syndrome
ID OXIDATIVE STRESS; RISK-FACTORS; SUPPLEMENTATION; INFLAMMATION; ACID
AB Fruit purees can be added to diet as alternative sources of bioactive compounds for the prevention and/or improvement of the complications of metabolic syndrome. In this work we evaluated the effect of the intake of low-fat diets enriched with fruit purees (guava-strawberry, guava-blackberry, guava-soursop, guava-passion fruit) on the body weight and biochemical markers in metabolic syndrome analogy (MSA)-induced rats. The rats (n=6 for each treatment) were induced with a high fat diet and were injected with streptozotocin, one dose every week for 4 consecutive weeks after fasting overnight, then healthy rats were fed with standard diet and MS rats were fed with standard diet plus each of the fruit puree, for 4 weeks. As novel findings, the diet enriched with fruit purees was associated with a reduction in body weight (similar to 13-21 %) and a control in the metabolism of glucose by decreasing plasma glucose (similar to 59-63 %). Also, there was a reduction in the total cholesterol, triacylglycerols, low-density lipoproteins, and low enzymatic activities of alanine aminotransferase, alkaline phosphatase and gamma-glutamyl transferase, useful metabolites in the control of inflammatory processes in the liver. A notable improvement in the liver morphology was observed indicating that the treatments had a hepatoprotective effect. The diet enriched with guava-blackberry puree caused the best results on most biochemical markers of MS rats. Therefore, diets enriched with fruit purees can be an alternative for MS individuals for the control and improvement of the complications caused by this syndrome.
C1 [Mireya Morales-Avila, Ursula; Montalvo-Gonzalez, Efigenia] Inst Tecnol Tepic, Tecnol Nacl Mexico, Lab Integral Invest Alimentos, Tepic, Nayarit, Mexico.
   [Yahia, Elhadi M.] Univ Autonoma Queretaro, Fac Ciencias Nat, Queretaro, Mexico.
   [Montalvo-Gonzalez, Ruben; Mendeleev Becerra-Verdin, Eduardo] Univ Autonoma Nayarit, Lab Invest Clin Histol, Tepic, Nayarit, Mexico.
C3 Universidad Autonoma de Queretaro
RP Montalvo-González, E (corresponding author), Inst Tecnol Tepic, Tecnol Nacl Mexico, Lab Integral Invest Alimentos, Tepic, Nayarit, Mexico.
EM eduardo.becerra@uan.edu.mx; efimontalvo@gmail.com
RI Montalvo, Efigenia/AAR-7954-2020; yahia, elhadi/ABG-8101-2020
FU Tecnologico Nacional de Mexico [6173.17-P]; CONACYT-Mexico [211953]
FX We thank the Company Pures y Derivados de Nayarit for donating the raw
   materials. This work was supported by Tecnologico Nacional de Mexico
   (Grant no. 6173.17-P) and CONACYT-Mexico (Grant no. 211953).
CR [Anonymous], 2016, Diabetes
   Brownlee M, 2016, Williams textbook of endocrinology, P1484, DOI [10.1016/B978-0-323-29738-7.00033-2, DOI 10.1016/B978-0-323-29738-7.00033-2]
   Carillon J, 2013, FREE RADICAL BIO MED, V65, P254, DOI 10.1016/j.freeradbiomed.2013.06.022
   Choi H, 2016, ARCH GERONTOL GERIAT, V64, P51, DOI 10.1016/j.archger.2016.01.005
   de Oliveira LS, 2016, BIOMED PHARMACOTHER, V84, P1291, DOI 10.1016/j.biopha.2016.10.021
   Díaz-de-Cerio E, 2017, FOOD RES INT, V96, P64, DOI 10.1016/j.foodres.2017.03.019
   Durner L, 2016, CR CHIM, V19, P1451, DOI 10.1016/j.crci.2015.04.002
   Fishbein M. H, 2013, J PEDIAT GASTROENTER, V36, P54
   Houben T, 2017, BBA-MOL CELL BIOL L, V1862, P416, DOI 10.1016/j.bbalip.2016.07.008
   Jankovic A, 2015, REDOX BIOL, V6, P19, DOI 10.1016/j.redox.2015.06.018
   Jin SM, 2016, METABOLISM, V65, P1629, DOI 10.1016/j.metabol.2016.08.006
   Khanam PA, 2017, DIABETES METAB SYND, V11, pS577, DOI 10.1016/j.dsx.2017.04.007
   Klimis-Zacas D, 2016, J BERRY RES, V6, P225, DOI 10.3233/JBR-160136
   Liu XB, 2009, LIFE SCI, V84, P876, DOI 10.1016/j.lfs.2009.03.022
   Maulucci G, 2016, MOL ASPECTS MED, V49, P49, DOI 10.1016/j.mam.2016.03.001
   Najeeb Ullah Najeeb Ullah, 2016, Asian Pacific Journal of Tropical Disease, V6, P749, DOI 10.1016/S2222-1808(16)61123-4
   Pérez-Beltrán YE, 2017, J FUNCT FOODS, V35, P447, DOI 10.1016/j.jff.2017.06.022
   Rubin R., 2012, PATOLOGIA FUNDAMENTO
   Samout N, 2016, BIOMED PHARMACOTHER, V83, P1233, DOI 10.1016/j.biopha.2016.08.038
   Sawicka M, 2016, INT J CARDIOL, V222, P581, DOI 10.1016/j.ijcard.2016.07.054
   Shahidi F, 2015, J FUNCT FOODS, V18, P820, DOI 10.1016/j.jff.2015.06.018
   Siri-Tarino PW, 2016, J LIPID RES, V57, P1771, DOI 10.1194/jlr.R069575
   Siriwardhana N, 2013, J NUTR BIOCHEM, V24, P613, DOI 10.1016/j.jnutbio.2012.12.013
   Tsitsimpikou C, 2014, FOOD CHEM TOXICOL, V74, P9, DOI 10.1016/j.fct.2014.08.014
   Vahid F, 2015, GENE, V562, P8, DOI 10.1016/j.gene.2015.02.045
NR 25
TC 2
Z9 2
U1 3
U2 13
PU SOC CHILENA ANATOMIA
PI TEMUCO
PA CASILLA 54-D, TEMUCO, 00000, CHILE
SN 0717-9502
EI 0717-9367
J9 INT J MORPHOL
JI Int. J. Morphol.
PD FEB
PY 2020
VL 38
IS 1
BP 61
EP 68
PG 8
WC Anatomy & Morphology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anatomy & Morphology
GA JP0RS
UT WOS:000497982000012
DA 2025-06-11
ER

PT J
AU Wang, LN
   Wang, M
   Liu, XJ
   Tian, JQ
   Zhang, L
   Li, YY
AF Wang, Lina
   Wang, Min
   Liu, Xiaojun
   Tian, Jiaqi
   Zhang, Ling
   Li, Yuanyuan
TI The association between uric acid to high-density cholesterol ratio and
   depression: A population-based cross-sectional study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Uric acid to high-density cholesterol ratio; Depression; NHANES;
   Cross-sectional study
ID METABOLIC SYNDROME; IMMUNE-SYSTEM; LIPID-LEVELS; INFLAMMATION; ALCOHOL;
   DISEASE
AB Background: Depression is associated with inflammation, and the uric acid to HDL-C cholesterol ratio (UHR) has emerged as a potential marker of increased inflammation; however, the association between UHR and depression is unclear. Therefore, we aimed to explore this association in a sample from the general US population. Methods: We conducted a cross-sectional study of 11,444 participants >= 20 years of age from the 2009-2014 NHANES database. We conducted weighted multivariate logistic regression analyses and restricted cubic spline function (RCS) models exploring the association between UHR and risk of depression, as well as subgroup analyses and tests of interaction. Results: UHR was positively associated with depression, especially in participants who drank alcohol (interaction P < 0.05).The prevalence of depression increased by 4 % for each 1-unit increase in UHR (OR = 1.04, 95 % CI = 1.02, 1.07, P = 0.003). After dividing the UHR into quartiles compared with the lowest reference group for UHR, participants in the fourth quartile had a significantly increased risk of depression after full adjustment (OR = 1.36, 95 % CI = 1.03, 1.80, P = 0.033).There was a linear dose-response relationship between the UHR and the risk of depression (P for nonlinear = 0.744). Limitations: As this was a cross-sectional study, we could not determine a causal relationship between UHR and depression. Conclusion: The UHR is positively associated with an increased prevalence of depression among adults in the U.S.
C1 [Wang, Lina] Weifang Peoples Hosp, Dept Nursing, Weifang, Peoples R China.
   [Wang, Min] Shandong First Med Univ, East Branch, Intens Care Unit, Shandong Prov Hosp, Jinan, Peoples R China.
   [Li, Yuanyuan] Shandong First Med Univ, Shandong Prov Hosp, Dept Nursing, Jinan 250000, Peoples R China.
   [Liu, Xiaojun; Tian, Jiaqi; Zhang, Ling] Shandong Univ, Sch Nursing & Rehabil, Jinan 250000, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical
   Sciences; Shandong First Medical University & Shandong Academy of
   Medical Sciences; Shandong University
RP Li, YY (corresponding author), Shandong First Med Univ, Shandong Prov Hosp, Dept Nursing, Jinan 250000, Peoples R China.
EM yuanyuanquan7@126.com
RI wang, lin/HZK-4145-2023
CR Aktas G, 2023, POSTGRAD MED, V135, P519, DOI 10.1080/00325481.2023.2214058
   Aktas G, 2022, POSTGRAD MED, V134, P297, DOI 10.1080/00325481.2022.2039007
   Aktas G, 2020, AGING MALE, V23, P1098, DOI 10.1080/13685538.2019.1678126
   Ames B.N., 1981, P NATL ACAD SCI-BIOL, V78, P6858, DOI 10.1073/pnas.78.11.6858
   Ancelin ML, 2010, BIOL PSYCHIAT, V68, P125, DOI 10.1016/j.biopsych.2010.04.011
   Balci SB, 2024, BRATISL MED J, V125, P145, DOI 10.4149/BLL_2023_130
   Bazmandegan G, 2024, NUTR METAB CARDIOVAS, V34, P1014, DOI 10.1016/j.numecd.2023.12.022
   Beurel E, 2020, NEURON, V107, P234, DOI 10.1016/j.neuron.2020.06.002
   Black CN, 2018, J AFFECT DISORDERS, V225, P684, DOI 10.1016/j.jad.2017.09.003
   Bowman G.L., 2010, Uric Acid as a CNS Antioxidant, V19, P1331, DOI [10.3233/JAD-2010-1330, DOI 10.3233/JAD-2010-1330]
   Chaudhari K, 2010, INDIAN J CLIN BIOCHE, V25, P77, DOI 10.1007/s12291-010-0016-z
   Cho KH, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23158623
   Curtin Lester R, 2012, Vital Health Stat 2, P1
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   Deisenhammer EA, 2004, PSYCHIAT RES, V121, P253, DOI 10.1016/j.psychres.2003.09.007
   Deng FX, 2024, BMC CARDIOVASC DISOR, V24, DOI 10.1186/s12872-024-03824-z
   Elmer B.M., 2012, TRENDS NEUROSCI, V35, P660, DOI 10.1016/j.tins.2012.08.001
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   Glantzounis GK, 2005, CURR PHARM DESIGN, V11, P4145, DOI 10.2174/138161205774913255
   Gleeson M, 2011, NAT REV IMMUNOL, V11, P607, DOI 10.1038/nri3041
   Gonçalves MCB, 2022, CNS DRUGS, V36, P787, DOI 10.1007/s40263-022-00934-0
   Hak AE, 2008, ARTHRITIS RES THER, V10, DOI 10.1186/ar2519
   Han XX, 2023, J HEALTH POPUL NUTR, V42, DOI 10.1186/s41043-023-00458-3
   Harsanyi S, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24010578
   Hay SI, 2017, LANCET, V389, pE1
   Kim JW, 2014, J CLIN PSYCHIAT, V75, P1242, DOI 10.4088/JCP.13r08898
   Kocak MZ, 2019, REV ASSOC MED BRAS, V65, P9, DOI 10.1590/1806-9282.65.1.9
   Kosekli MA, 2023, ACTA CLIN CROAT, V62, P277, DOI 10.20471/acc.2023.62.02.04
   Kosekli MA, 2021, REV ASSOC MED BRAS, V67, P549, DOI 10.1590/1806-9282.20201005
   Kupferberg A, 2016, NEUROSCI BIOBEHAV R, V69, P313, DOI 10.1016/j.neubiorev.2016.07.002
   Kuria Mary W, 2012, ISRN Psychiatry, V2012, P482802, DOI 10.5402/2012/482802
   Kurtkulagi O, 2021, ROM J INTERN MED, V59, P403, DOI 10.2478/rjim-2021-0023
   Lam RW, 2013, AUST NZ J PSYCHIAT, V47, P989, DOI 10.1177/0004867413488222
   Liu Y, 2022, PSYCHIAT CLIN PSYCH, V32, P313, DOI 10.5152/pcp.2022.22473
   Liu YH, 2024, LIPIDS HEALTH DIS, V23, DOI 10.1186/s12944-024-02285-9
   Maes M, 1997, ACTA PSYCHIAT SCAND, V95, P212, DOI 10.1111/j.1600-0447.1997.tb09622.x
   Malhi GS, 2018, LANCET, V392, P2299, DOI 10.1016/S0140-6736(18)31948-2
   Manea L, 2012, CAN MED ASSOC J, V184, pE191, DOI 10.1503/cmaj.110829
   Mathers CD, 2006, PLOS MED, V3, DOI 10.1371/journal.pmed.0030442
   Ménard C, 2016, NEUROSCIENCE, V321, P138, DOI 10.1016/j.neuroscience.2015.05.053
   Meng XD, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0229626
   Monroe SM, 2022, ANNU REV CLIN PSYCHO, V18, P329, DOI 10.1146/annurev-clinpsy-072220-021440
   Moradi Yousef, 2021, Clin Diabetes Endocrinol, V7, P4, DOI 10.1186/s40842-021-00117-8
   Moylan S, 2013, MOL PSYCHIATR, V18, P595, DOI 10.1038/mp.2012.33
   Oh J, 2017, J AFFECT DISORDERS, V213, P51, DOI 10.1016/j.jad.2017.02.002
   Park B, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10061422
   Romeo J, 2007, BRIT J NUTR, V98, pS111, DOI 10.1017/S0007114507838049
   Schwingshackl L, 2014, NUTR METAB CARDIOVAS, V24, P929, DOI 10.1016/j.numecd.2014.03.003
   Smith Kerri, 2014, Nature, V515, P181, DOI 10.1038/515180a
   Tamatam Anand, 2012, Indian J Hum Genet, V18, P20, DOI 10.4103/0971-6866.96639
   Tang HJ, 2021, ARTIF CELL NANOMED B, V49, P565, DOI 10.1080/21691401.2021.1961798
   Trivedi MH, 2020, J CLIN PSYCHIAT, V81, DOI 10.4088/JCP.UT17042BR1C
   Wang HJ, 2010, WORLD J GASTROENTERO, V16, P1304, DOI 10.3748/wjg.v16.i11.1304
   Weisskopf M.G., 2007, Plasma Urate and Risk of Parkinson's Disease, V166, P561, DOI [10.1093/aje/kwm127, DOI 10.1093/AJE/KWM127]
   Wen SL, 2012, CLIN BIOCHEM, V45, P49, DOI 10.1016/j.clinbiochem.2011.10.010
   Wium-Andersen MK, 2017, ACTA PSYCHIAT SCAND, V136, P424, DOI 10.1111/acps.12793
   World Health Organization, 2017, WHOMSDMER20172
   World Health Organization. Regional Office for the Eastern Mediterranean, 2019, Depression
   Zhang C, 2020, J PSYCHIATR RES, V130, P9, DOI 10.1016/j.jpsychires.2020.07.012
   Zhang HF, 2024, FRONT ENDOCRINOL, V15, DOI 10.3389/fendo.2024.1402336
   Zhang YN, 2020, INT J ENDOCRINOL, V2020, DOI 10.1155/2020/5953461
NR 61
TC 1
Z9 1
U1 17
U2 17
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JUN 15
PY 2025
VL 379
BP 502
EP 509
DI 10.1016/j.jad.2025.03.023
EA MAR 2025
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 0KZ0T
UT WOS:001449855900001
PM 40054537
DA 2025-06-11
ER

PT J
AU Kirpekar, VC
   Faye, AD
   Bhave, SH
   Tadke, R
   Gawande, S
AF Kirpekar, Vivek C.
   Faye, Abhijeet D.
   Bhave, Sudhir H.
   Tadke, Rahul
   Gawande, Sushi
TI Lurasidone-induced anemia: Is there a need for hematological monitoring?
SO INDIAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Anemia; blood monitoring; lurasidone; reversible
AB Lurasidone is a newer drug used for treating schizophrenia and depression in bipolar disorder. Although comparatively safe, some side effects can occur with its use such as akathisia, extrapyramidal reaction, metabolic syndrome, and hyperprolactinemia. Blood dyscrasia with lurasidone is rarely reported in the literature except for few case reports. We present two cases of schizophrenia, treated with lurasidone developing anemia after variable period of treatment and reverting after stopping lurasidone. These cases emphasize the timely monitoring of blood parameters for prevention or early detection of anemia in patients treated with lurasidone.
C1 [Kirpekar, Vivek C.; Bhave, Sudhir H.; Tadke, Rahul; Gawande, Sushi] NKP Salve Inst Med Sci, Dept Psychiat, Nagpur, Maharashtra, India.
   [Kirpekar, Vivek C.; Faye, Abhijeet D.; Bhave, Sudhir H.; Tadke, Rahul; Gawande, Sushi] Late Mangeshkar Hosp, Digdoh Hills,Hingna Rd, Nagpur 440019, Maharashtra, India.
RP Faye, AD (corresponding author), Late Mangeshkar Hosp, Digdoh Hills,Hingna Rd, Nagpur 440019, Maharashtra, India.; Faye, AD (corresponding author), NKP Salve Inst Med Sci, Dept Psychiat OPD 10, 2nd Floor,OPD Bldg, Nagpur 440019, Maharashtra, India.
EM abhijeetfaye12@gmail.com
RI kirpekar, vivek/AAI-1180-2019
CR Bawa Radhika, 2015, Innov Clin Neurosci, V12, P21
   Cruz Martin P, 2011, P T, V36, P489
   Greene EM, PHARMACOTHERAPY PATH
   Pompili M, 2018, EXPERT OPIN DRUG SAF, V17, P197, DOI 10.1080/14740338.2017.1379989
   Rafi M, 2018, INDIAN J PSYCHOL MED, V40, P191, DOI 10.4103/IJPSYM.IJPSYM_374_17
   Sood S, 2017, CLIN PSYCHOPHARM NEU, V15, P413, DOI 10.9758/cpn.2017.15.4.413
   Sunovion Pharmaceuticals, LAT 18 5MG 37MG 74MG
   Sunovion Pharmaceuticals Inc, 2013, LAT LAUR HYDR PACK I
NR 8
TC 5
Z9 5
U1 0
U2 3
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 0253-7613
EI 1998-3751
J9 INDIAN J PHARMACOL
JI Indian J. Pharmacol.
PD JUL-AUG
PY 2019
VL 51
IS 4
BP 276
EP 278
DI 10.4103/ijp.IJP_434_18
PG 3
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IY4OP
UT WOS:000486373200008
PM 31571715
OA Green Published
DA 2025-06-11
ER

PT J
AU Leung, JWC
   Ghosal, G
   Wang, WQ
   Shen, X
   Wang, JD
   Li, L
   Chen, JJ
AF Leung, Justin Wai-Chung
   Ghosal, Gargi
   Wang, Wenqi
   Shen, Xi
   Wang, Jiadong
   Li, Lei
   Chen, Junjie
TI Alpha Thalassemia/Mental Retardation Syndrome X-linked Gene Product ATRX
   Is Required for Proper Replication Restart and Cellular Resistance to
   Replication Stress
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID ONCOGENE-INDUCED SENESCENCE; DNA-DAMAGE; MENTAL-RETARDATION; GENOMIC
   INTEGRITY; HISTONE CHAPERONE; S PHASE; PROTEIN; MUTATIONS; CELLS;
   RECOMBINATION
AB Alpha thalassemia/mental retardation syndrome X-linked (ATRX) is a member of the SWI/SNF protein family of DNA-dependent ATPases. It functions as a chromatin remodeler and is classified as an SNF2-like helicase. Here, we showed somatic knock-out of ATRX displayed perturbed S-phase progression as well as hypersensitivity to replication stress. ATRX is recruited to sites of DNA damage, required for efficient checkpoint activation and faithful replication restart. In addition, we identified ATRX as a binding partner of MRE11-RAD50-NBS1 (MRN) complex. Together, these results suggest a non-canonical function of ATRX in guarding genomic stability.
C1 [Leung, Justin Wai-Chung; Ghosal, Gargi; Wang, Wenqi; Shen, Xi; Wang, Jiadong; Li, Lei; Chen, Junjie] Univ Texas MD Anderson Canc Ctr, Dept Expt Radiat Oncol, Houston, TX 77030 USA.
C3 University of Texas System; UTMD Anderson Cancer Center
RP Chen, JJ (corresponding author), Univ Texas MD Anderson Canc Ctr, Dept Expt Radiat Oncol, Unit 66, 1515 Holcombe Blvd,Room Y3-6006, Houston, TX 77030 USA.
EM jchen8@mdanderson.org
RI chen, junjie/LEB-0600-2024
OI Leung, Justin Wai Chung/0000-0003-4601-390X; Wang,
   Wenqi/0000-0003-4053-5088; Ghosal, Gargi/0000-0001-8399-5354
FU National Institutes of Health [CA089239, CA092312]; Dept. of Defense
   [W81XWH-05-1-0470]
FX This work was supported in part by Grants CA089239 and CA092312 (to J.
   C.) from the National Institutes of Health.Recipient of an Era of Hope
   Scholar award from the Dept. of Defense (W81XWH-05-1-0470) and a member
   of the M. D. Anderson Cancer Center (CA016672).
CR Abraham RT, 2001, GENE DEV, V15, P2177, DOI 10.1101/gad.914401
   Bansbach CE, 2009, GENE DEV, V23, P2405, DOI 10.1101/gad.1839909
   Bartkova J, 2006, NATURE, V444, P633, DOI 10.1038/nature05268
   Baumann C, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1001137
   Boe SO, 2006, J CELL SCI, V119, P3284, DOI 10.1242/jcs.03068
   Bryant HE, 2009, EMBO J, V28, P2601, DOI 10.1038/emboj.2009.206
   Cardoso C, 2000, J MED GENET, V37, P746, DOI 10.1136/jmg.37.10.746
   Ciccia A, 2012, MOL CELL, V47, P396, DOI 10.1016/j.molcel.2012.05.024
   De La Fuente R, 2011, REPRODUCTION, V142, P221, DOI 10.1530/REP-10-0380
   Di Micco R, 2006, NATURE, V444, P638, DOI 10.1038/nature05327
   Drané P, 2010, GENE DEV, V24, P1253, DOI 10.1101/gad.566910
   Draskovic I, 2009, P NATL ACAD SCI USA, V106, P15726, DOI 10.1073/pnas.0907689106
   Falbo KB, 2009, NAT STRUCT MOL BIOL, V16, P1167, DOI 10.1038/nsmb.1686
   Falck J, 2012, EMBO REP, V13, P561, DOI 10.1038/embor.2012.58
   Ge XQ, 2010, J CELL BIOL, V191, P1285, DOI 10.1083/jcb.201007074
   Ghosal G, 2012, J BIOL CHEM, V287, P34225, DOI 10.1074/jbc.M112.400135
   Gibbons RJ, 2003, NAT GENET, V34, P446, DOI 10.1038/ng1213
   GIBBONS RJ, 1995, CELL, V80, P837, DOI 10.1016/0092-8674(95)90287-2
   Goldberg AD, 2010, CELL, V140, P678, DOI 10.1016/j.cell.2010.01.003
   Heaphy CM, 2011, SCIENCE, V333, P425, DOI 10.1126/science.1207313
   Higgs DR, 2005, ANN NY ACAD SCI, V1054, P92, DOI 10.1196/annals.1345.012
   Huen MSY, 2007, CELL, V131, P901, DOI 10.1016/j.cell.2007.09.041
   Huh MS, 2012, J CLIN INVEST, V122, P4412, DOI 10.1172/JCI63765
   Iwase S, 2011, NAT STRUCT MOL BIOL, V18, P769, DOI 10.1038/nsmb.2062
   Jackson DA, 1998, J CELL BIOL, V140, P1285, DOI 10.1083/jcb.140.6.1285
   Law MJ, 2010, CELL, V143, P367, DOI 10.1016/j.cell.2010.09.023
   Leung JWC, 2012, P NATL ACAD SCI USA, V109, P4491, DOI 10.1073/pnas.1118720109
   Lewis PW, 2010, P NATL ACAD SCI USA, V107, P14075, DOI 10.1073/pnas.1008850107
   Lovejoy CA, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002772
   Ma HT, 2011, METHODS MOL BIOL, V761, P151, DOI 10.1007/978-1-61779-182-6_10
   Petermann E, 2010, MOL CELL, V37, P492, DOI 10.1016/j.molcel.2010.01.021
   Picketts DJ, 1996, HUM MOL GENET, V5, P1899, DOI 10.1093/hmg/5.12.1899
   Ritchie K, 2008, J CELL BIOL, V180, P315, DOI 10.1083/jcb.200706083
   Tittel-Elmer M, 2009, EMBO J, V28, P1142, DOI 10.1038/emboj.2009.60
   Weston R, 2012, GENE DEV, V26, P1558, DOI 10.1101/gad.193516.112
   Wilson BG, 2011, NAT REV CANCER, V11, P481, DOI 10.1038/nrc3068
   Wong LH, 2010, GENOME RES, V20, P351, DOI 10.1101/gr.101477.109
   Yuan JS, 2012, MOL CELL, V47, P410, DOI 10.1016/j.molcel.2012.05.025
   Yuan JS, 2009, GENE DEV, V23, P2394, DOI 10.1101/gad.1836409
   Yusufzai T, 2009, GENE DEV, V23, P2400, DOI 10.1101/gad.1831509
   Zou L, 2003, SCIENCE, V300, P1542, DOI 10.1126/science.1083430
NR 41
TC 79
Z9 101
U1 0
U2 11
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 1
PY 2013
VL 288
IS 9
BP 6342
EP 6350
DI 10.1074/jbc.M112.411603
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 102CJ
UT WOS:000315820700029
PM 23329831
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Shen, YH
   Zhang, L
   Gan, YH
   Wang, XW
   Wang, J
   LeMaire, SA
   Coselli, JS
   Wang, XL
AF Shen, YH
   Zhang, L
   Gan, YH
   Wang, XW
   Wang, J
   LeMaire, SA
   Coselli, JS
   Wang, XL
TI Up-regulation of PTEN (phosphatase and tensin homolog deleted on
   chromosome ten) mediates p38 MAPK stress signal-induced inhibition of
   insulin signaling - A cross-talk between stress signaling and insulin
   signaling in resistin-treated human endothelial cells
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID ACTIVATED PROTEIN-KINASES; INFLAMMATORY CYTOKINES; METABOLIC SYNDROME;
   SKELETAL-MUSCLE; INDUCED PHOSPHORYLATION; DEPENDENT DILATATION; RECEPTOR
   SUBSTRATE-1; LEPTIN LEVELS; IN-VIVO; GLUCOSE
AB The key feature of metabolic syndrome, a cluster of metabolic and cardiovascular disorders, is systemic insulin resistance, which is associated with dysregulated endothelial nitric-oxide synthase ( eNOS). Stress signaling induced by inflammation can inhibit insulin signaling. However, molecular mechanisms for the cross-talk between stress signaling and insulin resistance are only partially understood. Resistin, an adipokine/ cytokine, is involved in inflammatory processes that could lead to insulin resistance status and vascular diseases. In the current study, we observed that resistin inhibited insulin signaling and eNOS activation in endothelial cells. Up-regulation of PTEN ( phosphatase and tensin homolog deleted on chromosome ten) expression by resistin may mediate the inhibitory effects. Activated stress signaling p38 MAPK, but not JNK, is involved in PTEN up-regulation. We further found that p38 target transcriptional factor activating transcription factor-2 (ATF-2) bound to ATF sites in the PTEN promoter. The phosphorylation/ activation of ATF-2 and its binding to PTEN promoter were increased by resistin treatment. In summary, up-regulation of PTEN is involved in the inhibitory effects of resistin on insulin signaling and eNOS activation in endothelial cells. Resistin induces PTEN expression by activating stress signaling p38 pathway, which may activate target transcription factor ATF-2, which in turn induces PTEN expression. Our findings suggest that resistin-mediated inhibition of insulin signaling and eNOS activation may contribute to cardiovascular diseases.
C1 Baylor Coll Med, Div Cardiothorac Surg, Michael E DeBakey Dept Surg, Houston, TX 77030 USA.
   St Lukes Episcopal Hosp, Texas Heart Inst, Sect Adult Cardiac Surg, Houston, TX USA.
C3 Baylor College of Medicine; Texas Heart Institute; Saint Lukes Episcopal
   Hospital
RP Baylor Coll Med, Div Cardiothorac Surg, Michael E DeBakey Dept Surg, NAB 2010,1 Baylor Plaza, Houston, TX 77030 USA.
EM hyshen@bcm.tmc.edu; xlwang@bcm.tmc.edu
RI shen, ying/HHS-5635-2022
OI LeMaire, Scott/0000-0002-8736-4266
FU NHLBI NIH HHS [R01-HL071608, R01-HL066053] Funding Source: Medline
CR Aguirre V, 2000, J BIOL CHEM, V275, P9047, DOI 10.1074/jbc.275.12.9047
   Azuma K, 2003, OBES RES, V11, P997, DOI 10.1038/oby.2003.137
   Banerjee RR, 2003, J MOL MED, V81, P218, DOI 10.1007/s00109-003-0428-9
   Baron AD, 1999, AM J CARDIOL, V84, p25J
   Begum N, 2003, FRONT BIOSCI-LANDMRK, V8, pS796, DOI 10.2741/1146
   Bhagat K, 1997, CIRCULATION, V96, P3042, DOI 10.1161/01.CIR.96.9.3042
   Bokarewa M, 2005, J IMMUNOL, V174, P5789, DOI 10.4049/jimmunol.174.9.5789
   Bonora E, 1998, DIABETES, V47, P1643, DOI 10.2337/diabetes.47.10.1643
   Calabro P, 2004, CIRCULATION, V110, P3335, DOI 10.1161/01.CIR.0000147825.97879.E7
   Carlson CJ, 2003, DIABETES, V52, P634, DOI 10.2337/diabetes.52.3.634
   Davis RJ, 2000, CELL, V103, P239, DOI 10.1016/S0092-8674(00)00116-1
   de Alvaro C, 2004, J BIOL CHEM, V279, P17070, DOI 10.1074/jbc.M312021200
   DeFea K, 1997, J BIOL CHEM, V272, P31400, DOI 10.1074/jbc.272.50.31400
   Downes CP, 2001, BIOCHEM SOC T, V29, P846, DOI 10.1042/0300-5127:0290846
   Fujinami A, 2004, CLIN CHIM ACTA, V339, P57, DOI 10.1016/j.cccn.2003.09.009
   GAN Y, 2005, J BIOL CHEM
   Graveleau C, 2005, J BIOL CHEM, V280, P31679, DOI 10.1074/jbc.M504008200
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Haffner S, 2003, CIRCULATION, V108, P1541, DOI 10.1161/01.CIR.0000088845.17586.EC
   Hall JF, 2000, P NATL ACAD SCI USA, V97, P14022, DOI 10.1073/pnas.97.26.14022
   Han J, 1997, NATURE, V386, P296, DOI 10.1038/386296a0
   Heidenreich O, 1999, J BIOL CHEM, V274, P14434, DOI 10.1074/jbc.274.20.14434
   Hingorani AD, 2000, CIRCULATION, V102, P994, DOI 10.1161/01.CIR.102.9.994
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Hockings SC, 1998, P NATL ACAD SCI USA, V95, P1410, DOI 10.1073/pnas.95.4.1410
   Holcomb IN, 2000, EMBO J, V19, P4046, DOI 10.1093/emboj/19.15.4046
   Huang C, 2002, DIABETES, V51, P2090, DOI 10.2337/diabetes.51.7.2090
   Huang CS, 1999, J BIOL CHEM, V274, P12229, DOI 10.1074/jbc.274.18.12229
   Janknecht R, 1997, EMBO J, V16, P1620, DOI 10.1093/emboj/16.7.1620
   JIANG G, 2002, FRONT BIOSCI, V7, P903
   Kaser S, 2003, BIOCHEM BIOPH RES CO, V309, P286, DOI 10.1016/j.bbrc.2003.07.003
   Kereiakes DJ, 2003, CIRCULATION, V108, P1552, DOI 10.1161/01.CIR.0000093203.00632.2B
   Kim KM, 2001, J BIOL CHEM, V276, P37409, DOI 10.1074/jbc.M106728200
   Kitagawa Y, 2004, DIABETOLOGIA, V47, P1847, DOI 10.1007/s00125-004-1530-4
   Koistinen HA, 2003, DIABETOLOGIA, V46, P1324, DOI 10.1007/s00125-003-1196-3
   Kurlawalla-Martinez C, 2005, MOL CELL BIOL, V25, P2498, DOI 10.1128/MCB.25.6.2498-2510.2005
   Lee YH, 2003, J BIOL CHEM, V278, P2896, DOI 10.1074/jbc.M208359200
   Leslie NR, 2002, CELL SIGNAL, V14, P285, DOI 10.1016/S0898-6568(01)00234-0
   Lu SC, 2002, FEBS LETT, V530, P158, DOI 10.1016/S0014-5793(02)03450-6
   Manning AM, 2003, NAT REV DRUG DISCOV, V2, P554, DOI 10.1038/nrd1132
   Michell BJ, 2001, J BIOL CHEM, V276, P17625, DOI 10.1074/jbc.C100122200
   Moon B, 2003, AM J PHYSIOL-ENDOC M, V285, pE106, DOI 10.1152/ajpendo.00457.2002
   Morrow VA, 2003, J BIOL CHEM, V278, P31629, DOI 10.1074/jbc.M212831200
   Muse ED, 2004, J CLIN INVEST, V114, P232, DOI 10.1172/JCI200421270
   Nagaev I, 2001, BIOCHEM BIOPH RES CO, V285, P561, DOI 10.1006/bbrc.2001.5173
   Nicholson KM, 2002, CELL SIGNAL, V14, P381, DOI 10.1016/S0898-6568(01)00271-6
   Ohkawa F, 1995, CARDIOVASC RES, V30, P711, DOI 10.1016/0008-6363(95)00101-8
   Ort T, 2005, ENDOCRINOLOGY, V146, P2200, DOI 10.1210/en.2004-1421
   Palanivel R, 2005, FEBS LETT, V579, P5049, DOI 10.1016/j.febslet.2005.08.011
   Patel L, 2003, BIOCHEM BIOPH RES CO, V300, P472, DOI 10.1016/S0006-291X(02)02841-3
   Patel SD, 2004, SCIENCE, V304, P1154, DOI 10.1126/science.1093466
   Rangwala SM, 2004, DIABETES, V53, P1937, DOI 10.2337/diabetes.53.8.1937
   Reaven Gerald M., 1998, Journal of Basic and Clinical Physiology and Pharmacology, V9, P387
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Reilly MP, 2004, J CLIN ENDOCR METAB, V89, P3872, DOI 10.1210/jc.2003-031676
   Reilly MP, 2003, CIRCULATION, V108, P1546, DOI 10.1161/01.CIR.0000088846.10655.E0
   Reusch JEB, 2002, AM J CARDIOL, V90, p19G
   Sato N, 2005, ENDOCRINOLOGY, V146, P273, DOI 10.1210/en.2004-0985
   Satoh H, 2004, J CLIN INVEST, V114, P224, DOI 10.1172/JCI200420785
   Silha JV, 2003, EUR J ENDOCRINOL, V149, P331, DOI 10.1530/eje.0.1490331
   Silswal N, 2005, BIOCHEM BIOPH RES CO, V334, P1092, DOI 10.1016/j.bbrc.2005.06.202
   Simpson L, 2001, EXP CELL RES, V264, P29, DOI 10.1006/excr.2000.5130
   Steppan CM, 2001, NATURE, V409, P307, DOI 10.1038/35053000
   Steppan CM, 2001, P NATL ACAD SCI USA, V98, P502, DOI 10.1073/pnas.98.2.502
   Stiles B, 2004, P NATL ACAD SCI USA, V101, P2082, DOI 10.1073/pnas.0308617100
   Storz P, 2002, FRONT BIOSCI-LANDMRK, V7, pD886, DOI 10.2741/storz
   Tan Y, 1996, EMBO J, V15, P4629, DOI 10.1002/j.1460-2075.1996.tb00840.x
   Verma S, 2003, CIRCULATION, V108, P736, DOI 10.1161/01.CIR.0000084503.91330.49
   Wang XZ, 1996, SCIENCE, V272, P1347, DOI 10.1126/science.272.5266.1347
   Way JM, 2001, J BIOL CHEM, V276, P25651, DOI 10.1074/jbc.C100189200
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Whitmarsh AJ, 1997, MOL CELL BIOL, V17, P2360, DOI 10.1128/MCB.17.5.2360
   Wijesekara N, 2005, MOL CELL BIOL, V25, P1135, DOI 10.1128/MCB.25.3.1135-1145.2005
   Wyatt AW, 2002, FASEB J, V16, P1584, DOI 10.1096/fj.01-0125com
   Zarubin T, 2005, CELL RES, V15, P11, DOI 10.1038/sj.cr.7290257
   Zhang JL, 2003, DIABETIC MED, V20, P828, DOI 10.1046/j.1464-5491.2003.01057.x
   Zhao M, 1999, MOL CELL BIOL, V19, P21
NR 77
TC 122
Z9 162
U1 0
U2 7
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI ROCKVILLE
PA 11200 ROCKVILLE PIKE, SUITE 302, ROCKVILLE, MD, UNITED STATES
SN 0021-9258
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 24
PY 2006
VL 281
IS 12
BP 7727
EP 7736
DI 10.1074/jbc.M511105200
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 022BZ
UT WOS:000236031000005
PM 16418168
OA hybrid
DA 2025-06-11
ER

PT J
AU Molendi-Coste, O
   Legry, V
   Leclercq, IA
AF Molendi-Coste, O.
   Legry, V.
   Leclercq, I. A.
TI Dietary lipids and NAFLD: suggestions for improved nutrition
SO ACTA GASTRO-ENTEROLOGICA BELGICA
LA English
DT Review
DE NAFLD; dietary recommendations; saturated fatty acids; monounsaturated
   fatty fatty acids; poyunsaturated fatty acid
ID FATTY LIVER-DISEASE; METABOLIC SYNDROME; INSULIN-RESISTANCE; HEPATIC
   STEATOSIS; NONALCOHOLIC STEATOHEPATITIS; MONOUNSATURATED FAT; DESATURASE
   ACTIVITY; LINOLEIC-ACID; INFLAMMATION; OBESITY
AB Non-alcoholic fatty liver disease (NAFLD) ranges from steatosis and hepatic insulin resistance to non-alcoholic steatohepatitis (NASH), advanced fibrosis and cirrhosis. NAFLD is now considered as the hepatic manifestation of the metabolic syndrome, and both are triggered by mechanisms including inflammation, lipid overload and oxidative stress in adipose tissue and liver. Despite accumulation of numerous data on NAFLD physiopathology, therapeutic modulation of the pathways involved appear insufficiently efficient or associated with serious adverse effects. The increased prevalence of NAFLD and metabolic syndrome during the last decades was associated with deep modifications of dietary habits, especially increased fat intakes. Recent literature provides clues of increased saturated (SFA) and n-6 polyunsaturated fatty acids (PUFA) as well as reduced n-3 PUFA in the diet of NAFLD and NASH patients. Indeed, strong data support the detrimental role of high SFA and n-6/n-3 ratio as well as low monounsaturated fatty acids (MUFA) and n-3 PUFA on metabolic parameters, which are ameliorated by administration of n-3 PUFA and MUFA. Despite governments and health associations having revised their recommendations for n-3 PUFA intakes upward during the last decade, those are still inferior to levels proved of therapeutic efficiency and are still not reached in the general population. This short review discusses these issues and provides consequent pragmatic suggestions for enhanced dietary measures for prevention of NAFLD and metabolic syndrome in the general population. (Acta gastroenterol belg., 2010, 73, 431-436)
C1 [Molendi-Coste, O.; Legry, V.; Leclercq, I. A.] Catholic Univ Louvain, Inst Rech Expt & Clin, Lab Hepatogastroenterol, B-1200 Brussels, Belgium.
C3 Universite Catholique Louvain
RP Leclercq, IA (corresponding author), Catholic Univ Louvain, Inst Rech Expt & Clin, Lab Hepatogastroenterol, GAEN 53-79,Ave Mounier 53, B-1200 Brussels, Belgium.
EM isabelle.leclercq@uclouvain.be
RI Molendi-Coste, Olivier/HKW-3196-2023
OI Molendi-Coste, Olivier/0000-0002-0498-9456
FU FRS-FNRS [3.4578.07, M.IS : F.45.08.08]; la Direction de la Recherche
   Scientifique de la Communaute Francaise de Belgique (ARC) [05/10-328];
   University FSR
FX This work was supported by FRS-FNRS grants (N<SUP>o</SUP>3.4578.07 and
   M.IS : F.45.08.08), la Direction de la Recherche Scientifique de la
   Communaute Francaise de Belgique (ARC grant, 05/10-328), University FSR
   grants to I.L.; O.M.C. and I.L. are FRS-FNRS post-doctoral researcher
   and reseach associated, respectively.
CR Abete I, 2010, NUTR REV, V68, P214, DOI 10.1111/j.1753-4887.2010.00280.x
   Anderson BM, 2009, LIPIDS HEALTH DIS, V8, DOI 10.1186/1476-511X-8-33
   [Anonymous], 2008, INT SUMM CONCL DIET
   Araya J, 2004, CLIN SCI, V106, P635, DOI 10.1042/CS20030326
   Araya J, 2010, OBESITY, V18, P1460, DOI 10.1038/oby.2009.379
   Assy N, 2009, WORLD J GASTROENTERO, V15, P1809, DOI 10.3748/wjg.15.1809
   Bannenberg GL, 2010, THESCIENTIFICWORLDJO, V10, P676, DOI 10.1100/tsw.2010.57
   Basu A, 2006, ARTERIOSCL THROM VAS, V26, P995, DOI 10.1161/01.ATV.0000214295.86079.d1
   Bellentani S, 2009, ANN HEPATOL, V8, pS4, DOI 10.1016/S1665-2681(19)31820-4
   Bordoni A, 2006, GENES NUTR, V1, P95, DOI 10.1007/BF02829951
   Bulló M, 2007, PUBLIC HEALTH NUTR, V10, P1164, DOI 10.1017/S1368980007000663
   Byrne CD, 2010, PROSTAG LEUKOTR ESS, V82, P265, DOI 10.1016/j.plefa.2010.02.012
   Calder PC, 2006, AM J CLIN NUTR, V83, p1505S, DOI 10.1093/ajcn/83.6.1505S
   Capanni M, 2006, ALIMENT PHARM THER, V23, P1143, DOI 10.1111/j.1365-2036.2006.02885.x
   Cave M, 2007, J NUTR BIOCHEM, V18, P184, DOI 10.1016/j.jnutbio.2006.12.006
   Cortez-Pinto H, 2006, CLIN NUTR, V25, P816, DOI 10.1016/j.clnu.2006.01.027
   Das UN, 2005, PROSTAG LEUKOTR ESS, V72, P343, DOI 10.1016/j.plefa.2005.01.002
   Das UN, 2002, EXP BIOL MED, V227, P989, DOI 10.1177/153537020222701106
   Das UN, 2006, CURR PHARM BIOTECHNO, V7, P467, DOI 10.2174/138920106779116856
   Das UN, 2008, LIPIDS HEALTH DIS, V7, DOI 10.1186/1476-511X-7-37
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   Olalla LMD, 2009, NUTR HOSP, V24, P113
   Delavar MA, 2009, ASIA PAC J CLIN NUTR, V18, P285
   DOLECEK TA, 1992, P SOC EXP BIOL MED, V200, P177, DOI 10.3181/00379727-200-43413
   Eaton SB, 2010, AM J CLIN NUTR, V91, P295, DOI 10.3945/ajcn.2009.29058
   Ebbesson Sven O E, 2007, J Cardiometab Syndr, V2, P244, DOI 10.1111/j.1559-4564.2007.07393.x
   Ebrahimi M, 2009, ACTA CARDIOL, V64, P321, DOI 10.2143/AC.64.3.2038016
   Elinav E, 2006, J PATHOL, V209, P121, DOI 10.1002/path.1950
   Fabbrini E, 2010, HEPATOLOGY, V51, P679, DOI 10.1002/hep.23280
   Farrell GC, 2006, HEPATOLOGY, V43, pS99, DOI 10.1002/hep.20973
   Ferrante AW, 2007, J INTERN MED, V262, P408, DOI 10.1111/j.1365-2796.2007.01852.x
   González-Périz A, 2010, THESCIENTIFICWORLDJO, V10, P832, DOI 10.1100/tsw.2010.77
   Gormaz JG, 2010, PROG LIPID RES, V49, P407, DOI 10.1016/j.plipres.2010.05.003
   Harris WS, 2007, J CARDIOVASC MED, V8, pS50, DOI 10.2459/01.JCM.0000289274.64933.45
   HARRISON SA, 2004, CLIN LIVER DIS, V8, pR12
   Harrison Stephen A, 2004, Clin Liver Dis, V8, P715, DOI 10.1016/j.cld.2004.04.011
   Hevener AL, 2007, J CLIN INVEST, V117, P1658, DOI 10.1172/JCI31561
   Huang ES, 2009, DIABETES CARE, V32, P2225, DOI 10.2337/dc09-0459
   Huang W, 2010, DIABETES, V59, P347, DOI 10.2337/db09-0016
   Hussein O, 2007, WORLD J GASTROENTERO, V13, P361, DOI 10.3748/wjg.v13.i3.361
   Hwu CM, 2008, INT J CLIN PRACT, V62, P1441, DOI 10.1111/j.1742-1241.2008.01818.x
   Indart A, 2002, FREE RADICAL RES, V36, P1051, DOI 10.1080/1071576021000006716
   Julius U, 2003, EXP CLIN ENDOCR DIAB, V111, P60, DOI 10.1055/s-2003-39230
   Kopecky J, 2009, P NUTR SOC, V68, P361, DOI 10.1017/S0029665109990231
   Lanthier N, 2010, AM J PHYSIOL-GASTR L, V298, pG107, DOI 10.1152/ajpgi.00391.2009
   Leclercq IA, 2007, J HEPATOL, V47, P142, DOI 10.1016/j.jhep.2007.04.002
   Linseisen J, 2009, EUR J CLIN NUTR, V63, pS61, DOI 10.1038/ejcn.2009.75
   Luczynski W, 2010, POSTEP HIG MED DOSW, V64, P156
   LUPIEN J. R., 1994, FOOD NUTR AGR EDIBLE
   Martinelli N, 2008, AM J CLIN NUTR, V88, P941, DOI 10.1093/ajcn/88.4.941
   Masterton GS, 2010, ALIMENT PHARM THER, V31, P679, DOI 10.1111/j.1365-2036.2010.04230.x
   MOLENDI-COSTE O., 2010, GASTROENTER IN PRESS
   Nakamura MT, 2004, ANNU REV NUTR, V24, P345, DOI 10.1146/annurev.nutr.24.121803.063211
   Neuschwander-Tetri BA, 2010, HEPATOLOGY, V52, P774, DOI 10.1002/hep.23719
   Neuschwander-Tetri BA, 2009, CLIN LIVER DIS, V13, P649, DOI 10.1016/j.cld.2009.07.006
   Reese AC, 2009, J NUTRIGENET NUTRIGE, V2, P149, DOI 10.1159/000235565
   Rodríguez-Villar C, 2004, DIABETIC MED, V21, P142, DOI 10.1046/j.1464-5491.2003.01086.x
   Ruidavets JB, 2007, J EPIDEMIOL COMMUN H, V61, P810, DOI 10.1136/jech.2006.052126
   Serhan CN, 2009, J THROMB HAEMOST, V7, P44, DOI 10.1111/j.1538-7836.2009.03396.x
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Simopoulos AP, 2001, LIPIDS, V36, pS83, DOI 10.1007/s11745-001-0672-1
   SIMOPOULOS AP, 1994, FREE RADICAL BIO MED, V17, P367, DOI 10.1016/0891-5849(94)90023-X
   Simopoulos AP, 2002, BIOMED PHARMACOTHER, V56, P365, DOI 10.1016/S0753-3322(02)00253-6
   Spadaro L, 2008, DIGEST LIVER DIS, V40, P194, DOI 10.1016/j.dld.2007.10.003
   Stienstra R, 2007, ENDOCRINOLOGY, V148, P2753, DOI 10.1210/en.2007-0014
   Tanaka N, 2008, J CLIN GASTROENTEROL, V42, P413, DOI 10.1097/MCG.0b013e31815591aa
   Tarantino G, 2010, WORLD J GASTROENTERO, V16, P4773, DOI 10.3748/wjg.v16.i38.4773
   Vallim T, 2010, PROSTAG LEUKOTR ESS, V82, P211, DOI 10.1016/j.plefa.2010.02.016
   van den Berg SAA, 2010, NUTR METAB, V7, DOI 10.1186/1743-7075-7-24
   Vanni E, 2010, DIGEST LIVER DIS, V42, P320, DOI 10.1016/j.dld.2010.01.016
   Vuppalanchi R, 2007, J CLIN GASTROENTEROL, V41, P206, DOI 10.1097/01.mcg.0000225515.28536.3a
   Yashodhara BM, 2009, POSTGRAD MED J, V85, P84, DOI 10.1136/pgmj.2008.073338
   Zelber-Sagil S, 2007, J HEPATOL, V47, P711, DOI 10.1016/j.jhep.2007.06.020
   Zuliani G, 2009, CURR PHARM DESIGN, V15, P4087, DOI 10.2174/138161209789909773
NR 74
TC 15
Z9 16
U1 0
U2 9
PU UNIV CATHOLIQUE LOUVAIN-UCL
PI BRUSSELS
PA CLIN UNIV SAINT LUC, AVE HIPPOCRATE 10, BRUSSELS, B-1200, BELGIUM
SN 1784-3227
J9 ACTA GASTRO-ENT BELG
JI Acta Gastro-Enterol. Belg.
PD OCT-DEC
PY 2010
VL 73
IS 4
BP 431
EP 436
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 716WZ
UT WOS:000287005500001
PM 21299150
DA 2025-06-11
ER

PT J
AU Jenzsch, A
   Eick, S
   Rassoul, F
   Purschwitz, R
   Jentsch, H
AF Jenzsch, Axel
   Eick, Sigrun
   Rassoul, Fausi
   Purschwitz, Regina
   Jentsch, Holger
TI Nutritional intervention in patients with periodontal disease: clinical,
   immunological and microbiological variables during 12 months
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Periodontitis; Diet; Metabolic syndrome
ID GINGIVAL CREVICULAR FLUID; GLUTATHIONE-PEROXIDASE; LIPID-PEROXIDATION;
   OXIDATIVE STRESS; CYTOKINE BIOLOGY; FATTY-ACIDS; INFLAMMATION; ELASTASE;
   HEALTH; MYELOPEROXIDASE
AB The role of nutrition in onset. progression and treatment of periodontitis has not been thoroughly evaluated. In the present prospective clinical study, we investigated the influence of a nutritional intervention on changes in clinical, microbiological and immunological periodontal variables during a period of 12 months in patients with the metabolic syndrome and chronic periodontitis. Twenty female subjects with the metabolic syndrome and mild to moderate chronic periodontitis participated in a guided nutritional intervention programme. Examinations were assessed before, and at 2 weeks, 3, 6 and 12 months after intervention. Clinical measurements included probing depth, Loe and Silness gingival index and Quigley-Hein plaque index. In gingival crevicular fluid, periodontopathogens, levels of IL-1 beta and IL-6 as well as the activity of granulocyte elastase were determined. In stimulated saliva, antioxidative and oxidative variables were measured. After 12 months the following significant changes could be observed: reduction of clinical probing depth (2.40 v. 2.20mm; P<0.001), reduction of gingival inflammation (gingival index 1.13 v. 0.9; P<0.001), reduced concentrations of IL-1 beta (4.63 v. 1.10pg/ml per sited P<0.001) as well as IL-6 (1.85 v. 0.34pg/ml per site; P=0.022) in gingival crevicular fluid. Bacterial counts in gingival crevicular fluid as well as oxidative and antioxidative variables in saliva showed no significant changes. Only salivary catalase showed a tendency to lower values. These findings indicate that in patients with the metabolic syndrome whole-some nutrition might reduce inflammatory variables of periodontal disease and promote periodontal health.
C1 [Jenzsch, Axel; Purschwitz, Regina; Jentsch, Holger] Univ Leipzig, Dept Conservat Dent & Periodontol, D-04103 Leipzig, Germany.
   [Eick, Sigrun] Univ Jena, Inst Med Microbiol, Dept Oral Microbiol, Jena, Germany.
   [Rassoul, Fausi] Univ Leipzig, Inst Lab Med Clin Chem & Mol Diagnost, D-04103 Leipzig, Germany.
C3 Leipzig University; Friedrich Schiller University of Jena; Leipzig
   University
RP Jenzsch, A (corresponding author), Univ Leipzig, Dept Conservat Dent & Periodontol, Liebigstr 57, D-04103 Leipzig, Germany.
EM axel.jenzsch@medizin.uni-leipzig.de
CR Al-Zahrani MS, 2003, J PERIODONTOL, V74, P610, DOI 10.1902/jop.2003.74.5.610
   Alpagot T, 2001, J PERIODONTAL RES, V36, P169, DOI 10.1034/j.1600-0765.2001.360305.x
   ALZAHRANI MS, 2004, ORAL HLTH PREV DENT, V24, P345
   ARMITAGE GC, 1994, J PERIODONTOL, V65, P120, DOI 10.1902/jop.1994.65.2.120
   ARUOMA OI, 1994, FOOD CHEM TOXICOL, V32, P671, DOI 10.1016/0278-6915(94)90011-6
   Ashimoto A, 1996, ORAL MICROBIOL IMMUN, V11, P266, DOI 10.1111/j.1399-302X.1996.tb00180.x
   BEERS RF, 1952, J BIOL CHEM, V195, P133
   Blignaut J B, 1992, Clin Prev Dent, V14, P25
   Boyd Linda D, 2003, Dent Clin North Am, V47, P337, DOI 10.1016/S0011-8532(02)00103-9
   Browning LM, 2006, DIABETES TECHNOL THE, V8, P45, DOI 10.1089/dia.2006.8.45
   DAVIES B, 1989, BIOCHEM J, V258, P801, DOI 10.1042/bj2580801
   DEMENDEZ I, 1991, ARCH BIOCHEM BIOPHYS, V289, P319, DOI 10.1016/0003-9861(91)90417-H
   Drugarin D, 1998, Roum Arch Microbiol Immunol, V57, P295
   ENWONWU CO, 1995, AM J CLIN NUTR, V61, p430S, DOI 10.1093/ajcn/61.2.430S
   ESTERBAUER H, 1990, METHOD ENZYMOL, V186, P407
   Fouad AF, 2002, J CLIN MICROBIOL, V40, P3223, DOI 10.1128/JCM.40.9.3223-3231.2002
   Giugliano D, 2006, J AM COLL CARDIOL, V48, P677, DOI 10.1016/j.jacc.2006.03.052
   Grimble RF, 1998, Z ERNAHRUNGSWISS, V37, P57
   Grimble RF, 1998, NUTRITION, V14, P634, DOI 10.1016/S0899-9007(98)00010-0
   GUSTAFSSON A, 1992, J CLIN PERIODONTOL, V19, P535, DOI 10.1111/j.1600-051X.1992.tb00680.x
   Ho YS, 1998, ENVIRON HEALTH PERSP, V106, P1219, DOI 10.2307/3433989
   Hu FB, 2002, JAMA-J AM MED ASSOC, V288, P2569, DOI 10.1001/jama.288.20.2569
   Ishihara Y, 1997, J PERIODONTAL RES, V32, P524, DOI 10.1111/j.1600-0765.1997.tb00568.x
   Jenkinson A, 1999, EUR J CLIN NUTR, V53, P523, DOI 10.1038/sj.ejcn.1600783
   Kesavalu L, 2006, J DENT RES, V85, P648, DOI 10.1177/154405910608500713
   KOERBER KV, 2004, VOLLWERT ERNAEHRUNG
   LAWRENCE RA, 1976, BIOCHEM BIOPH RES CO, V71, P952, DOI 10.1016/0006-291X(76)90747-6
   Leitzmann C, 2005, PUBLIC HEALTH NUTR, V8, P753, DOI 10.1079/PHN2005781
   LOE HARALD, 1963, ACTA ODONTOL SCAND, V21, P533, DOI 10.3109/00016356309011240
   Anwar AT, 2006, AM J CLIN NUTR, V83, P1395, DOI 10.1093/ajcn/83.6.1395
   MILLER DR, 1984, J CLIN PERIODONTOL, V11, P1, DOI 10.1111/j.1600-051X.1984.tb01303.x
   MIYASAKI KT, 1991, J PERIODONTOL, V62, P761, DOI 10.1902/jop.1991.62.12.761
   PALMBLAD J, 1977, SCAND J HAEMATOL, V19, P293
   Ritchie CS, 2003, NUTRITION, V19, P475, DOI 10.1016/S0899-9007(02)01043-2
   Rudney JD, 2003, J PERIODONTAL RES, V38, P465, DOI 10.1034/j.1600-0765.2003.00670.x
   Saito T, 2001, J DENT RES, V80, P1631, DOI 10.1177/00220345010800070701
   SAKKI TK, 1995, COMMUNITY DENT ORAL, V23, P155, DOI 10.1111/j.1600-0528.1995.tb00220.x
   Sculley DV, 2002, P NUTR SOC, V61, P137, DOI 10.1079/PNS2001141
   Tsai CC, 2005, J PERIODONTAL RES, V40, P378, DOI 10.1111/j.1600-0765.2005.00818.x
   TURESKY S, 1970, J PERIODONTOL, V41, P41, DOI 10.1902/jop.1970.41.1.41
   Van Dyke Thomas E, 2005, J Int Acad Periodontol, V7, P3
   Wei PF, 2004, J PERIODONTAL RES, V39, P287, DOI 10.1111/j.1600-0765.2004.00744.x
   Wu DY, 2004, ANN NY ACAD SCI, V1031, P422, DOI 10.1196/annals.1331.062
NR 43
TC 54
Z9 55
U1 1
U2 7
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD MAR 28
PY 2009
VL 101
IS 6
BP 879
EP 885
DI 10.1017/S0007114508047776
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 428OM
UT WOS:000264858200016
PM 18713481
OA Bronze
DA 2025-06-11
ER

PT J
AU Osama, H
   Hamed, EO
   Mahmoud, MA
   Abdelrahim, MEA
AF Osama, Hasnaa
   Hamed, Ehdaa O.
   Mahmoud, Muhammed A.
   Abdelrahim, Mohamed E. A.
TI The Effect of Hesperidin and Diosmin Individually or in Combination on
   Metabolic Profile and Neuropathy among Diabetic Patients with Metabolic
   Syndrome: A Randomized Controlled Trial
SO JOURNAL OF DIETARY SUPPLEMENTS
LA English
DT Article
DE hesperidin; diosmin; metabolic syndrome; diabetic neuropathy; citrus
   flavonoids; integrative medicine; phytotherapy
ID OXIDATIVE STRESS; DENSITY-LIPOPROTEIN; BLOOD-PRESSURE; MODEL
AB Current evidence supports the association of metabolic syndrome (MetS) with neuropathy. Limited data are available on proper strategies to control metabolic disorders and neuropathy among patients with type2 diabetes mellitus (T2DM). We aimed to determine hesperidin and diosmin efficacy individually and in combination among T2DM patients with neuropathy and meet MetS criteria. In this parallel-group designed trial, 129 T2DM patients with MetS and neuropathy were recruited and randomized to receive their oral hypoglycemics with either hesperidin (1g/day), or diosmin (1g/day), or combination of both or oral hypoglycemics without intervention for 12 weeks. Diabetic neuropathy was evaluated using Michigan Neuropathy Screening Instrument (MNSI) at baseline and after trial. Anthropometric parameters, blood glucose and lipid profile were also assessed before and after the intervention using paired student t-test within groups. The trial is registered at clinicaltrials.gov as NCT05243238. By completion of the trial duration, both hesperidin and diosmin groups showed significant reduction in blood glucose, triglycerides (TGs) and low density lipoprotein (LDL) from baseline (p<0.05). However, the magnitude of improvement in metabolic components significantly increased with hesperidin and diosmin combination. Although MNSI scores improved significantly in both groups, the reduction was more significant with the combination of hesperidin and diosmin. Moreover, the change in MNSI score was significantly correlated with the improvement in metabolic profile components including LDL, TGs and fasting blood glucose. Oral supplementation of hesperidin and diosmin was associated with improvement in metabolic syndrome and diabetic neuropathy and the combination of both was superior in efficacy.
C1 [Osama, Hasnaa; Abdelrahim, Mohamed E. A.] Beni Suef Univ, Fac Pharm, Clin Pharm Dept, Bani Suwayf, Egypt.
   [Hamed, Ehdaa O.] Agr Res Ctr ARC, Anim Hlth Res Inst AHRI, Dept Chem Toxicol & Nutr Deficiency, Toxicol Unit,El Fayoum Governorate Lab, Cairo, Egypt.
   [Mahmoud, Muhammed A.] Natl Org Drug Control & Res, Giza, Egypt.
C3 Egyptian Knowledge Bank (EKB); Beni Suef University; Animal Health
   Research Institute (AHRI); National Organization for Drug Control &
   Research (NODCAR)
RP Osama, H (corresponding author), Beni Suef Univ, Fac Pharm, Clin Pharm Dept, Bani Suwayf, Egypt.
EM hasnaa_osama2010@yahoo.com
RI Osama, Hassna/ACV-9217-2022; Abdelrahim, Mohamed/AAJ-7075-2020
OI abdelrahim, mohamed/0000-0003-0227-8404; osama,
   hasnaa/0000-0003-2990-5981
CR Ahmed S, 2016, INFLAMMATION, V39, P1783, DOI 10.1007/s10753-016-0413-4
   AlKurd R, 2022, NUTRIENTS, V14, DOI 10.3390/nu14061245
   Apovian CM, 2019, ADV THER, V36, P44, DOI 10.1007/s12325-018-0824-8
   Bagnati M, 2021, BIOMED RES INT, V2021, DOI 10.1155/2021/3508281
   Bellou V, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194127
   Callaghan B, 2013, ANN NEUROL, V74, P397, DOI 10.1002/ana.23986
   Callaghan BC, 2016, DIABETES CARE, V39, P801, DOI 10.2337/dc16-0081
   Carballo-Villalobos AI, 2016, BIOMED RES INT, V2016, DOI 10.1155/2016/8263463
   Cesar TB, 2010, NUTR RES, V30, P689, DOI 10.1016/j.nutres.2010.09.006
   Chung S, 2020, FOOD SCI NUTR, V8, P5976, DOI 10.1002/fsn3.1883
   Constans J, 2015, CLIN NUTR, V34, P1093, DOI 10.1016/j.clnu.2014.12.016
   El-Fawal R, 2018, BIOMED PHARMACOTHER, V102, P930, DOI 10.1016/j.biopha.2018.03.162
   Hashemi MS, 2021, COMPLEMENT MED RES, V28, P226, DOI 10.1159/000510986
   Homayouni F, 2018, PHYTOTHER RES, V32, P1073, DOI 10.1002/ptr.6046
   Carballo-Villalobos AI, 2018, BIOMED PHARMACOTHER, V97, P310, DOI 10.1016/j.biopha.2017.10.077
   Jain D, 2014, J INTEGR MED-JIM, V12, P35, DOI 10.1016/S2095-4964(14)60001-7
   Jung UJ, 2004, J NUTR, V134, P2499, DOI 10.1093/jn/134.10.2499
   Kazamel M, 2021, MUSCLE NERVE, V63, P285, DOI 10.1002/mus.27086
   Lin YG, 2011, J AGR FOOD CHEM, V59, P4496, DOI 10.1021/jf1044475
   Liu K, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/6713194
   Mayneris-Perxachs J, 2019, J FUNCT FOODS, V61, DOI 10.1016/j.jff.2019.103504
   McKee M, 1999, BMJ-BRIT MED J, V319, P312, DOI 10.1136/bmj.319.7205.312
   Mendrick DL, 2018, TOXICOL SCI, V162, P36, DOI 10.1093/toxsci/kfx233
   Miwa Y, 2005, J NUTR SCI VITAMINOL, V51, P460, DOI 10.3177/jnsv.51.460
   Mukkerjee D., 2020, INT J PHARM RES TECH, V10, P25, DOI DOI 10.31838/IJPRT/10.02.04
   Nayebi Neda, 2019, J Complement Integr Med, V16, DOI 10.1515/jcim-2018-0088
   Oh TJ, 2019, J OBES METAB SYNDR, V28, P112, DOI 10.7570/jomes.2019.28.2.112
   Parveen S., 2020, Traditional and Integrative Medicine, V5, P191, DOI DOI 10.18502/TIM.V5I4.5164
   Pla-Pagà L, 2019, NUTR REV, V77, P845, DOI 10.1093/nutrit/nuz036
   Pop-Busui R, 2017, DIABETES CARE, V40, P136, DOI 10.2337/dc16-2042
   Rampello L, 2012, ACTA MEDICA MEDITERR, V28, P219
   Rangel-Huerta OD, 2015, J NUTR, V145, P1808, DOI 10.3945/jn.115.213660
   Rizk Sherine Maher, 2009, Saudi Pharm J, V17, P199, DOI 10.1016/j.jsps.2009.08.008
   Rizza S, 2011, J CLIN ENDOCR METAB, V96, pE782, DOI 10.1210/jc.2010-2879
   Roberts CK, 2013, COMPR PHYSIOL, V3, P1, DOI 10.1002/cphy.c110062
   Salden BN, 2016, AM J CLIN NUTR, V104, P1523, DOI 10.3945/ajcn.116.136960
   Srinivasan S, 2012, CHEM-BIOL INTERACT, V195, P43, DOI 10.1016/j.cbi.2011.10.003
   Staniewska, 2016, SAFETY TREATMENT DIE
   Visnagri A, 2014, PHARM BIOL, V52, P814, DOI 10.3109/13880209.2013.870584
   Wiggin TD, 2009, DIABETES, V58, P1634, DOI 10.2337/db08-1771
   Xiong HJ, 2019, DRUG DES DEV THER, V13, P3855, DOI 10.2147/DDDT.S227499
   Yari Z, 2020, EUR J NUTR, V59, P2569, DOI 10.1007/s00394-019-02105-2
   Yeboah K, 2016, J CLIN TRANSL ENDOCR, V5, P26, DOI 10.1016/j.jcte.2016.07.001
   YOUNG MJ, 1994, DIABETES CARE, V17, P557, DOI 10.2337/diacare.17.6.557
   Zilliox LA, 2019, CLIN AUTON RES, V29, P443, DOI 10.1007/s10286-019-00607-x
NR 45
TC 15
Z9 16
U1 4
U2 10
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1939-0211
EI 1939-022X
J9 J DIET SUPPL
JI J. Diet. Suppl.
PD SEP 3
PY 2023
VL 20
IS 5
BP 749
EP 762
DI 10.1080/19390211.2022.2107138
EA JUL 2022
PG 14
WC Nutrition & Dietetics; Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics; Pharmacology & Pharmacy
GA O0FC1
UT WOS:000838601600001
PM 35946912
DA 2025-06-11
ER

PT J
AU Rosés, C
   Garcia-Ibañez, P
   Agudelo, A
   Viadel, B
   Tomás-Cobos, L
   Gallego, E
   Carvajal, M
   Milagro, FI
   Barceló, A
AF Roses, Carles
   Garcia-Ibanez, Paula
   Agudelo, Agatha
   Viadel, Blanca
   Tomas-Cobos, Lidia
   Gallego, Elisa
   Carvajal, Micaela
   Milagro, Fermin I.
   Barcelo, Anna
TI Effects of Glucosinolate-Enriched Red Radish (Raphanus sativus) on In
   Vitro Models of Intestinal Microbiota and Metabolic Syndrome-Related
   Functionalities
SO ACS OMEGA
LA English
DT Article
ID SP-NOV.; GUT MICROBIOTA; GEN.-NOV.; NITRIC-OXIDE;
   BIFIDOBACTERIUM-ANIMALIS; OXIDATIVE STRESS; HUMAN FECES; BUTYRATE;
   BACTERIUM; BROCCOLI
AB The gut microbiotaprofile is determined by diet composition, andtherefore this interaction is crucial for promoting specific bacterialgrowth and enhancing the health status. Red radish (Raphanus sativus L.) contains severalsecondary plant metabolites that can exert a protective effect onhuman health. Recent studies have shown that radish leaves have ahigher content of major nutrients, minerals, and fiber than roots,and they have garnered attention as a healthy food or supplement.Therefore, the consumption of the whole plant should be considered,as its nutritional value may be of greater interest. The aim of thiswork is to evaluate the effects of glucosinolate (GSL)-enriched radishwith elicitors on the intestinal microbiota and metabolic syndrome-relatedfunctionalities by using an in vitro dynamic gastrointestinalsystem and several cellular models developed to study the GSL impacton different health indicators such as blood pressure, cholesterolmetabolism, insulin resistance, adipogenesis, and reactive oxygenspecies (ROS). The treatment with red radish had an influence on short-chainfatty acids (SCFA) production, especially on acetic and propionicacid and many butyrate-producing bacteria, suggesting that consumptionof the entire red radish plant (leaves and roots) could modify thehuman gut microbiota profile toward a healthier one. The evaluationof the metabolic syndrome-related functionalities showed a significantdecrease in the gene expression of endothelin, interleukin IL-6, andcholesterol transporter-associated biomarkers (ABCA1 and ABCG5), suggestingan improvement of three risk factors associated with metabolic syndrome.The results support the idea that the use of elicitors on red radishcrops and its further consumption (the entire plant) may contributeto improving the general health status and gut microbiota profile.
C1 [Roses, Carles; Barcelo, Anna] Univ Autonoma Barcelona, Serv Genom, Bellaterra 08193, Cerdanyola Del, Spain.
   [Garcia-Ibanez, Paula; Carvajal, Micaela] CEBAS CSIC, Ctr Edafol & Biol Aplicada Segura, Aquaporins Grp, E-30100 Murcia, Spain.
   [Garcia-Ibanez, Paula; Carvajal, Micaela] CEBAS CSIC, Ctr Edafol & Biol Aplicada Segura, Dept Food Sci Technol, Phytochem & Hlth Foods Lab, E-30100 Murcia, Spain.
   [Agudelo, Agatha] Sakata Seed Iber SL, Valencia 46021, Spain.
   [Agudelo, Agatha] Univ Politecn Valencia, UPV, Valencia 46022, Spain.
   [Viadel, Blanca; Tomas-Cobos, Lidia; Gallego, Elisa] AINIA, Technol Ctr, Paterna 46980, Valenca, Spain.
   [Milagro, Fermin I.] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.
   [Milagro, Fermin I.] Navarra Inst Hlth Res IdISNA, Pamplona 31008, Spain.
   [Milagro, Fermin I.] Inst Salud Carlos III, Ctr Investigac Biomed Red Fisiopatol Obes & Nutr C, Madrid, Spain.
C3 Autonomous University of Barcelona; Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC - Centro de Edafologia y Biologia Aplicada del
   Segura (CEBAS); Consejo Superior de Investigaciones Cientificas (CSIC);
   CSIC - Centro de Edafologia y Biologia Aplicada del Segura (CEBAS);
   Universitat Politecnica de Valencia; University of Navarra; University
   of Navarra; Instituto de Salud Carlos III
RP Milagro, FI (corresponding author), Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.; Milagro, FI (corresponding author), Navarra Inst Hlth Res IdISNA, Pamplona 31008, Spain.; Milagro, FI (corresponding author), Inst Salud Carlos III, Ctr Investigac Biomed Red Fisiopatol Obes & Nutr C, Madrid, Spain.
EM fmilagro@unav.es
RI Milagro, Fermin/F-2315-2015; Carvajal, Micaela/H-8920-2015
OI Carvajal, Micaela/0000-0001-7321-4956; Roses Pol,
   Carles/0000-0003-0060-9353
CR Angelova Z., 2006, BIOTECHNOL BIOTEC EQ, V20, P72, DOI DOI 10.1080/13102818.2006.10817345
   [Anonymous], INFLUENCE AEROSOCCUS
   [Anonymous], PUBLICATION UNDERSTA
   [Anonymous], DESULFOVIBRIO PIGER
   Azam A, 2013, J SCI FOOD AGR, V93, P3237, DOI 10.1002/jsfa.6165
   Bäckhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Baenas N, 2016, FOOD CHEM, V204, P314, DOI 10.1016/j.foodchem.2016.02.144
   Baenas N, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17020251
   Baenas N, 2014, J AGR FOOD CHEM, V62, P1881, DOI 10.1021/jf404876z
   Banihani SA, 2017, NUTRIENTS, V9, DOI 10.3390/nu9091014
   Bhandari SR, 2015, MOLECULES, V20, P15827, DOI 10.3390/molecules200915827
   Borrelli L, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-16560-6
   BRADFIELD CA, 1991, ADV EXP MED BIOL, V289, P153
   Castro-Torres I. G., 2012, J BIOMED BIOTECHNOL, V2012, DOI [10.1155/2012/161205, DOI 10.1155/2012/161205]
   CCummings J., 1989, GASTROINTESTINALPATH, P201
   Chung DH, 2012, NUTR RES PRACT, V6, P308, DOI 10.4162/nrp.2012.6.4.308
   Clarke JD, 2011, PHARMACOL RES, V64, P456, DOI 10.1016/j.phrs.2011.07.005
   Daillère R, 2016, IMMUNITY, V45, P931, DOI 10.1016/j.immuni.2016.09.009
   Dall'Asta M, 2012, NUTRITION, V28, P197, DOI 10.1016/j.nut.2011.06.005
   De Boever P, 2000, J NUTR, V130, P2599
   de la Fuente-Arrillaga C, 2010, PUBLIC HEALTH NUTR, V13, P1364, DOI 10.1017/S1368980009993065
   Dillon KM, 2021, ANGEW CHEM INT EDIT, V60, P6061, DOI 10.1002/anie.202014052
   Dong GQ, 2020, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00941
   Duncan SH, 2004, BRIT J NUTR, V91, P915, DOI 10.1079/BJN20041150
   Duncan SH, 2004, APPL ENVIRON MICROB, V70, P5810, DOI 10.1128/AEM.70.10.5810-5817.2004
   Eder K, 2009, INFLAMM RES, V58, P727, DOI 10.1007/s00011-009-0060-4
   Fasshauer M, 2004, BIOCHIMIE, V86, P779, DOI 10.1016/j.biochi.2004.09.016
   Finegold SM, 2004, ANAEROBE, V10, P41, DOI 10.1016/j.anaerobe.2003.10.002
   Förstermann U, 2010, PFLUG ARCH EUR J PHY, V459, P923, DOI 10.1007/s00424-010-0808-2
   Furusawa Y, 2013, NATURE, V504, P446, DOI 10.1038/nature12721
   Gao F, 2015, MOL MED REP, V12, P6555, DOI 10.3892/mmr.2015.4298
   Garcia-Ibañez P, 2021, FOODS, V10, DOI 10.3390/foods10051038
   Garcia-Ibañez P, 2020, J SCI FOOD AGR, V100, P2099, DOI 10.1002/jsfa.10233
   Geerlings SY, 2018, MICROORGANISMS, V6, DOI 10.3390/microorganisms6030075
   Ghayur MN, 2006, FUND CLIN PHARMACOL, V20, P57, DOI 10.1111/j.1472-8206.2005.00382.x
   Goodrich JK, 2014, CELL, V159, P789, DOI 10.1016/j.cell.2014.09.053
   GOSSLING J, 1975, INT J SYST BACTERIOL, V25, P202, DOI 10.1099/00207713-25-2-202
   Goyeneche R, 2015, J FUNCT FOODS, V16, P256, DOI 10.1016/j.jff.2015.04.049
   Guarner F, 2003, LANCET, V361, P512, DOI 10.1016/S0140-6736(03)12489-0
   Gunn PJ, 2017, PHYSIOL REP, V5, DOI 10.14814/phy2.13532
   Gupta P, 2014, BBA-REV CANCER, V1846, P405, DOI 10.1016/j.bbcan.2014.08.003
   HIDALGO IJ, 1989, GASTROENTEROLOGY, V96, P736
   Hiippala K, 2020, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.575455
   Hildebrand F, 2014, MICROBIOME, V2, DOI 10.1186/2049-2618-2-37
   Hwang IM, 2019, FOOD CHEM, V282, P127, DOI 10.1016/j.foodchem.2018.12.036
   HyunJi G., NUTR RES PRACTCE, DOI [10.4162/nrp.2021.15.e37&code=0161NRP&vmode=PUBREADER, DOI 10.4162/NRP.2021.15.E37&CODE=0161NRP&VMODE=PUBREADER]
   Ishida M, 2011, BREEDING SCI, V61, P208, DOI 10.1270/jsbbs.61.208
   Jabari L, 2012, INT J SYST EVOL MICR, V62, P2522, DOI 10.1099/ijs.0.032508-0
   Joyner MJ, 1997, J APPL PHYSIOL, V83, P1785, DOI 10.1152/jappl.1997.83.6.1785
   Jung KY, 2000, J PHARM PHARMACOL, V52, P1031, DOI 10.1211/0022357001774769
   Kawai K, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-28886-w
   Kim SM, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17071155
   Kim SunJu Kim SunJu, 2013, Australian Journal of Crop Science, V7, P1843
   Konikoff T, 2016, TRENDS MICROBIOL, V24, P523, DOI 10.1016/j.tim.2016.02.015
   Kontula P, 1998, APPL MICROBIOL BIOT, V50, P246, DOI 10.1007/s002530051284
   Ku KM, 2014, J SCI FOOD AGR, V94, P2090, DOI 10.1002/jsfa.6529
   Lawson PA, 2004, INT J SYST EVOL MICR, V54, P413, DOI 10.1099/ijs.0.02653-0
   Lee HG, 2022, MAR DRUGS, V20, DOI 10.3390/md20060354
   Lee JG, 2017, FOOD CHEM, V233, P60, DOI 10.1016/j.foodchem.2017.04.104
   구경형, 2006, [Journal of the Korean Society of Food Science and Nutrition, 한국식품영양과학회지], V35, P780
   Lee S, 2021, HORTIC ENVIRON BIOTE, V62, P581, DOI 10.1007/s13580-021-00345-y
   Lim S, 2020, APPL BIOL CHEM, V63, DOI 10.1186/s13765-020-00561-7
   Lino T, 2007, INT J SYST EVOL MICR, V57, P1840, DOI 10.1099/ijs.0.64717-0
   Liu HK, 2019, J FUNCT FOODS, V53, P136, DOI 10.1016/j.jff.2018.12.019
   Liu RH, 2013, ADV NUTR, V4, p384S, DOI 10.3945/an.112.003517
   Liu XX, 2018, TOXICOL APPL PHARM, V341, P56, DOI 10.1016/j.taap.2018.01.007
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   Looft T, 2013, INT J SYST EVOL MICR, V63, P1960, DOI 10.1099/ijs.0.044719-0
   Louis P, 2017, ENVIRON MICROBIOL, V19, P29, DOI 10.1111/1462-2920.13589
   Lubos E, 2008, FRONT BIOSCI-LANDMRK, V13, P5323, DOI 10.2741/3084
   Marzorati M, 2010, INT J FOOD MICROBIOL, V139, P168, DOI 10.1016/j.ijfoodmicro.2010.02.030
   McKnight Patrick E, 2010, The Corsini Encyclopedia of Psychology, P1, DOI [10.3109/9780203450307-26, DOI 10.3109/9780203450307-26]
   Menu Estelle, 2018, BMC Res Notes, V11, P206, DOI 10.1186/s13104-018-3300-2
   Mikkelsen KH, 2016, DIABETES OBES METAB, V18, P444, DOI 10.1111/dom.12637
   Million M, 2012, INT J OBESITY, V36, P817, DOI 10.1038/ijo.2011.153
   MOLLY K, 1993, APPL MICROBIOL BIOT, V39, P254, DOI 10.1007/BF00228615
   MOLLY K, 1994, MICROB ECOL HEALTH D, V7, P191, DOI 10.3109/08910609409141354
   Moreno DA, 2008, J SCI FOOD AGR, V88, P1472, DOI 10.1002/jsfa.3244
   Morgan DM, 2020, CLIN GASTROENTEROL H, V18, P984, DOI 10.1016/j.cgh.2019.06.035
   Morrison DJ, 2016, GUT MICROBES, V7, P189, DOI 10.1080/19490976.2015.1134082
   Nugroho ABD, 2020, PLANT MOL BIOL, V102, P171, DOI 10.1007/s11103-019-00939-2
   Paul S, 2019, J FOOD SCI, V84, P19, DOI 10.1111/1750-3841.14417
   Peng LY, 2009, J NUTR, V139, P1619, DOI 10.3945/jn.109.104638
   Poulos SP, 2010, EXP BIOL MED, V235, P1185, DOI 10.1258/ebm.2010.010063
   Rizzardini G, 2012, BRIT J NUTR, V107, P876, DOI 10.1017/S000711451100420X
   Rosés C, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020636
   Ruemmele FM, 2003, GUT, V52, P94, DOI 10.1136/gut.52.1.94
   Ryan KK, 2014, NATURE, V509, P183, DOI 10.1038/nature13135
   Schwiertz A, 2010, OBESITY, V18, P190, DOI 10.1038/oby.2009.167
   Sciarappa WJ, 2016, HORTSCIENCE, V51, P1344, DOI 10.21273/HORTSCI11040-16
   Sim WS, 2019, FOODS, V8, DOI 10.3390/foods8050170
   Skonieczna-Zydecka K, 2018, NUTRIENTS, V10, DOI 10.3390/nu10121939
   Spellerberg IF, 2003, GLOBAL ECOL BIOGEOGR, V12, P177, DOI 10.1046/j.1466-822X.2003.00015.x
   Takada T, 2016, INT J SYST EVOL MICR, V66, P4125, DOI 10.1099/ijsem.0.001323
   Takahashi K, 2016, DIGESTION, V93, P59, DOI 10.1159/000441768
   Tan HZ, 2019, FOOD RES INT, V116, P637, DOI 10.1016/j.foodres.2018.08.088
   Tian SC, 2018, J SCI FOOD AGR, V98, P1255, DOI 10.1002/jsfa.8654
   Tian XL, 2019, CANCER LETT, V448, P20, DOI 10.1016/j.canlet.2019.01.031
   van de Wiele T, 2007, J APPL MICROBIOL, V102, P452, DOI 10.1111/j.1365-2672.2006.03084.x
   Vargas JE, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01124
   Venkataraman A, 2016, MICROBIOME, V4, DOI 10.1186/s40168-016-0178-x
   Viadel B., 2012, EQUIPO MODULAR DIGES
   Wang YF, 2008, OBESITY, V16, P2323, DOI 10.1038/oby.2008.351
   Willems A, 1997, INT J SYST BACTERIOL, V47, P1201, DOI 10.1099/00207713-47-4-1201
   Witte JS, 1996, AM J EPIDEMIOL, V144, P1015, DOI 10.1093/oxfordjournals.aje.a008872
   WOOD JD, 1984, AM J PHYSIOL, V247, pG585, DOI 10.1152/ajpgi.1984.247.6.G585
   Yao ZW, 2013, PHARMACOL RES, V70, P139, DOI 10.1016/j.phrs.2013.01.006
   Zoetendal EG, 2003, INT J SYST EVOL MICR, V53, P211, DOI 10.1099/ijs.0.02362-0
NR 108
TC 5
Z9 5
U1 0
U2 6
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2470-1343
J9 ACS OMEGA
JI ACS Omega
PD JUN 22
PY 2023
VL 8
IS 26
BP 23373
EP 23388
DI 10.1021/acsomega.2c08128
EA JUN 2023
PG 16
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA K8IT1
UT WOS:001016031600001
PM 37426251
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sachdev, PS
   Brodaty, H
   Reppermund, S
   Kochan, NA
   Trollor, JN
   Draper, B
   Slavin, MJ
   Crawford, J
   Kang, K
   Broe, GA
   Mather, KA
   Lux, O
AF Sachdev, Perminder S.
   Brodaty, Henry
   Reppermund, Simone
   Kochan, Nicole A.
   Trollor, Julian N.
   Draper, Brian
   Slavin, Melissa J.
   Crawford, John
   Kang, Kristan
   Broe, G. Anthony
   Mather, Karen A.
   Lux, Ora
CA Memory Ageing Study Team
TI The Sydney Memory and Ageing Study (MAS): methodology and baseline
   medical and neuropsychiatric characteristics of an elderly
   epidemiological non-demented cohort of Australians aged 70-90 years
SO INTERNATIONAL PSYCHOGERIATRICS
LA English
DT Article
DE mild cognitive impairment; cognitive function; dementia; cognitive
   decline; magnetic resonance imaging (MRI); fMRI; metabolic syndrome;
   inflammatory markers; balance; falls; depression; anxiety; genetics;
   proteomics
ID MILD COGNITIVE IMPAIRMENT; WHITE-MATTER HYPERINTENSITIES;
   MINI-MENTAL-STATE; APOLIPOPROTEIN-E; NORMATIVE DATA; ALZHEIMER-DISEASE;
   APOE GENOTYPE; LIFE-STYLE; PREVALENCE; HEALTH
AB Background: The Sydney Memory and Ageing Study (Sydney MAS) was initiated in 2005 to examine the clinical characteristics and prevalence of mild cognitive impairment (MCI) and related syndromes, and to determine the rate of change in cognitive function over time.
   Methods: Non-demented community-dwelling individuals (N = 1037) aged 70-90 were recruited from two areas of Sydney, following a random approach to 8914 individuals on the electoral roll. They underwent detailed neuropsychiatric and medical assessments and donated a blood sample for clinical chemistry, proteomics and genomics. A knowledgeable informant was also interviewed. Structural MRI scans were performed on 554 individuals, and subgroups participated in studies of falls and balance, metabolic and inflammatory markers, functional MRI and prospective memory. The cohort is to be followed up with brief telephone reviews annually, and detailed assessments biannually.
   Results: This is a generally well-functioning cohort mostly living in private homes and rating their health as being better than average, although vascular risk factors are common. Most (95.5%) participants or their informants identified a cognitive difficulty, and 43.5% had impairment on at least one neuropsychological test. MCI criteria were met by 34.8%; with 19.3% qualifying for amnestic MCI, whereas 15.5% had non-amnestic MCI; 1.6% had impairment on neuropsychological test performance but no subjective complaints; and 5.8% could not be classified. The rate of MCI was 30.9% in the youngest (70-75) and 39.1% in the oldest (85-90) age bands. Rates of depression and anxiety were 7.1% and 6.9% respectively.
   Conclusions: Cognitive complaints are common in the elderly, and nearly one in three meet criteria for MCI. Longitudinal follow-up of this cohort will delineate the progression of complaints and objective cognitive impairment, and the determinants of such change.
C1 [Sachdev, Perminder S.] Prince Wales Hosp, UNSW Sch Psychiat, NPI, Euroa Ctr,Neuropsychiat Inst, Randwick, NSW 2031, Australia.
   [Sachdev, Perminder S.; Brodaty, Henry; Reppermund, Simone; Kochan, Nicole A.; Trollor, Julian N.; Draper, Brian; Slavin, Melissa J.; Crawford, John; Kang, Kristan; Mather, Karen A.; Lux, Ora; Memory Ageing Study Team] Univ New S Wales, Brain & Ageing Res Program, Sch Psychiat, Fac Med, Sydney, NSW, Australia.
   [Sachdev, Perminder S.; Brodaty, Henry; Draper, Brian; Broe, G. Anthony] Univ New S Wales, Sch Psychiat, Primary Dementia Collaborat Res Ctr, Fac Med, Sydney, NSW, Australia.
   [Brodaty, Henry; Draper, Brian] Prince Wales Hosp, Acad Dept Old Age Psychiat, Randwick, NSW 2031, Australia.
   [Broe, G. Anthony] Prince Wales Med Res Inst, Randwick, NSW, Australia.
   [Broe, G. Anthony] Prince Wales Hosp, Ageing Res Ctr, Randwick, NSW 2031, Australia.
   [Lux, Ora] Prince Wales Hosp, SE Area Lab Serv, Randwick, NSW 2031, Australia.
C3 University of New South Wales Sydney; Prince of Wales Hospital (POWH);
   University of New South Wales Sydney; University of New South Wales
   Sydney; University of New South Wales Sydney; Prince of Wales Hospital
   (POWH); Neuroscience Research Australia; University of New South Wales
   Sydney; Prince of Wales Hospital (POWH); University of New South Wales
   Sydney; Prince of Wales Hospital (POWH)
RP Sachdev, PS (corresponding author), Prince Wales Hosp, UNSW Sch Psychiat, NPI, Euroa Ctr,Neuropsychiat Inst, Barker St, Randwick, NSW 2031, Australia.
EM sachdev@unsw.edu.au
RI Reppermund, Simone/C-9329-2009; Karen, Mather/O-9795-2016; Brodaty,
   Henry/E-2753-2010; Sachdev, Perminder/ABC-1137-2020; Slavin,
   Melissa/F-7509-2010; Sachdev, Perminder/H-3968-2015
OI Trollor, Julian/0000-0002-7685-2977; Mather, Karen
   Anne/0000-0003-4143-8941; Kang, Kristan/0000-0002-2057-1033; Sachdev,
   Perminder/0000-0002-9595-3220; Brodaty, Henry/0000-0001-9487-6617
FU National Health and Medical Research Council of Australia [401184,
   350833]
FX DNA samples were extracted by Genetic Repositories Australia, an
   enabling facility, which is supported by a National Health and Medical
   Research Council of Australia Grant, 401184. The APOE genotyping was
   performed by Arezoo Assareh and Karen Mather under the supervision of
   Professor Peter Schofield and John Kwok at the Prince of Wales Medical
   Research Institute, Sydney, Australia. Blood samples were collected by
   South Eastern Area Laboratory Service. Angie Russell assisted with the
   preparation of the paper. We thank the participants for their
   enthusiastic support. This study was supported by a National Health and
   Medical Research Council of Australia Program Grant (ID 350833).
CR ABS, 2003, AG AUSTR CENS POP HO
   *ABS, 1998, MENT HLTH WELLB PROF
   Anderson TM, 2007, AM J GERIAT PSYCHIAT, V15, P467, DOI 10.1097/JGP.0b013e3180547053
   [Anonymous], 1993, The HalsteadReitan Neuropsychological Battery: theory and clinical interpretation
   [Anonymous], 1964, L'examen clinique en psychologie
   [Anonymous], 2020, Australia's Health 2020 Snapshots
   [Anonymous], WAIS R MANUAL
   [Anonymous], 2008, WAIS-IV: Administration and scoring manual
   [Anonymous], 2006, Census of Population and Housing
   [Anonymous], Republique
   [Anonymous], OLD PEOPL AUSTR SOC
   Bennett DA, 2002, NEUROLOGY, V59, P198, DOI 10.1212/WNL.59.2.198
   Benton A., 1966, BENTON TEST
   Benton A.L., 1967, CORTEX, V3, P32, DOI DOI 10.1016/S0010-9452(67)80005-4
   BLOSSOM CMS, 2007, J AM GERIATR SOC, V55, P1534
   Brandt J., 1988, NEUROPSY NEUROPSY BE, V1, P111, DOI [10.1001/archneur.1993.00540060039014, DOI 10.1037/T28542-000]
   Briganti EM, 2003, MED J AUSTRALIA, V179, P135, DOI 10.5694/j.1326-5377.2003.tb05471.x
   Costa P.T., 1992, Revised personality inventory (NEO PI-R) and neo five factor inventory NEO-FFI: Professional manual
   CRAWFORD JR, 1989, BRIT J CLIN PSYCHOL, V28, P275, DOI 10.1111/j.2044-8260.1989.tb01377.x
   Crook T H 3rd, 1992, Int Psychogeriatr, V4, P165, DOI 10.1017/S1041610292000991
   CUMMINGS JL, 1994, NEUROLOGY, V44, P2308, DOI 10.1212/WNL.44.12.2308
   de Jager CA, 2003, INT J GERIATR PSYCH, V18, P318, DOI 10.1002/gps.830
   DIENER E, 1985, J PERS ASSESS, V49, P71, DOI 10.1207/s15327752jpa4901_13
   Doty RL, 1996, LARYNGOSCOPE, V106, P353, DOI 10.1097/00005537-199603000-00021
   Ellis KA, 2009, INT PSYCHOGERIATR, V21, P672, DOI 10.1017/S1041610209009405
   Epping-Jordan J., 2000, WHO Bulletin of Mental Health, V6, P5
   Farrer LA, 1997, JAMA-J AM MED ASSOC, V278, P1349, DOI 10.1001/jama.278.16.1349
   Fastenau PS, 1998, J CLIN EXP NEUROPSYC, V20, P828, DOI 10.1076/jcen.20.6.828.1105
   FLICKER C, 1991, NEUROLOGY, V41, P1006, DOI 10.1212/WNL.41.7.1006
   FOLSTEIN MF, 1975, J PSYCHIAT RES, V12, P189, DOI 10.1016/0022-3956(75)90026-6
   GOLDBERG D, 1988, BMJ-BRIT MED J, V297, P897, DOI 10.1136/bmj.297.6653.897
   Graham JE, 1997, LANCET, V349, P1793, DOI 10.1016/S0140-6736(97)01007-6
   Grundman M, 2004, ARCH NEUROL-CHICAGO, V61, P59, DOI 10.1001/archneur.61.1.59
   Harris ME, 2002, J CLIN EXP NEUROPSYC, V24, P214, DOI 10.1076/jcen.24.2.214.995
   HENDERSON AS, 1995, LANCET, V346, P1387, DOI 10.1016/S0140-6736(95)92405-1
   Hindmarch I, 1998, DEMENT GERIATR COGN, V9, P20, DOI 10.1159/000051195
   HIXSON JE, 1990, J LIPID RES, V31, P545
   Hodge A, 2000, AUST NZ J PUBL HEAL, V24, P576, DOI 10.1111/j.1467-842X.2000.tb00520.x
   Ivnik R.J., 1992, Clinical Neuropsychologist, V6, P1, DOI 10.1080/13854049208401877
   Ivnik R.J., 1990, Psychological Assessment: A Journal of Consulting and Clinical Psychology, V2, P304, DOI DOI 10.1037/1040-3590.2.3.304
   Ivnik RJ., 1992, CLIN NEUROPSYCHOL, V6, P83, DOI DOI 10.1080/13854049208401880
   JORM AF, 1994, PSYCHOL MED, V24, P145, DOI 10.1017/S003329170002691X
   Jorm AF, 2004, PSYCHOL MED, V34, P1495, DOI 10.1017/S0033291704003162
   Jorm AF, 2007, NEUROPSYCHOLOGY, V21, P1, DOI 10.1037/0894-4105.21.1.1
   Kaplan E., 2001, Boston naming test-2 (BNT-2)
   Kessler R., 1994, FINAL VERSION UNPUB
   KLOVE H, 1963, MED CLIN N AM, V47, P1647, DOI 10.1016/S0025-7125(16)33515-5
   Kochan NA, 2010, AM J GERIAT PSYCHIAT, V18, P711, DOI 10.1097/JGP.0b013e3181d6b6a9
   Kumar R, 2005, DEMENT GERIATR COGN, V19, P67, DOI 10.1159/000082351
   Larrieu S, 2002, NEUROLOGY, V59, P1594, DOI 10.1212/01.WNL.0000034176.07159.F8
   LAWTON MP, 1969, GERONTOLOGIST, V9, P179, DOI 10.1093/geront/9.3_Part_1.179
   Lechevallier-Michel N, 2004, REV NEUROL-FRANCE, V160, P1059, DOI 10.1016/S0035-3787(04)71143-1
   Liu T, 2010, NEUROIMAGE, V51, P19, DOI 10.1016/j.neuroimage.2010.02.016
   Lopez OL, 2003, ARCH NEUROL-CHICAGO, V60, P1385, DOI 10.1001/archneur.60.10.1385
   Lord SR, 2002, J GERONTOL A-BIOL, V57, pM539, DOI 10.1093/gerona/57.8.M539
   Lord SR, 1999, J AM GERIATR SOC, V47, P1077, DOI 10.1111/j.1532-5415.1999.tb05230.x
   Mathers C., 1999, BURDEN DIS INJURY AU
   McLennan W, 1997, ASCO AUSTR STANDARD
   Mitchell T, 2008, INT PSYCHOGERIATR, V20, P77, DOI 10.1017/S1041610207005583
   MORRIS JC, 1993, NEUROLOGY, V43, P2412, DOI 10.1212/WNL.43.11.2412-a
   Nelson Hazel E., 1991, The National Adult Reading Test (NART)
   Petersen RC, 2001, ARCH NEUROL-CHICAGO, V58, P1985, DOI 10.1001/archneur.58.12.1985
   Petersen RC, 2004, J INTERN MED, V256, P183, DOI 10.1111/j.1365-2796.2004.01388.x
   Petersen RC, 2009, ARCH NEUROL-CHICAGO, V66, P1447, DOI 10.1001/archneurol.2009.266
   PODSIADLO D, 1991, J AM GERIATR SOC, V39, P142, DOI 10.1111/j.1532-5415.1991.tb01616.x
   Richardson J., 2004, Australian Econ Rev, V37, P62, DOI DOI 10.1111/J.1467-8462.2004.00308.X
   Ritchie K, 2002, LANCET, V360, P1759, DOI 10.1016/S0140-6736(02)11667-9
   Ritchie K, 2000, LANCET, V355, P225, DOI 10.1016/S0140-6736(99)06155-3
   Ritchie K, 2001, NEUROLOGY, V56, P37, DOI 10.1212/WNL.56.1.37
   Roberts RO, 2008, NEUROEPIDEMIOLOGY, V30, P58, DOI 10.1159/000115751
   Slavin MJ, 2010, AM J GERIAT PSYCHIAT, V18, P701, DOI 10.1097/JGP.0b013e3181df49fb
   Spreen O., 1969, Neurosensory Center Comprehensive Examination for Aphasia (NCCEA)
   Tombaugh TN, 1999, ARCH CLIN NEUROPSYCH, V14, P167, DOI 10.1016/S0887-6177(97)00095-4
   Tombaugh TN, 2004, ARCH CLIN NEUROPSYCH, V19, P203, DOI 10.1016/S0887-6177(03)00039-8
   Trollor JN, 2007, AM J GERIAT PSYCHIAT, V15, P455, DOI 10.1097/JGP.0b013e3180590ba9
   Unverzagt FW, 2001, NEUROLOGY, V57, P1655, DOI 10.1212/WNL.57.9.1655
   Waite LM, 2001, J NEUROL NEUROSUR PS, V71, P296, DOI 10.1136/jnnp.71.3.296
   WATSON D, 1988, J PERS SOC PSYCHOL, V54, P1063, DOI 10.1037/0022-3514.54.6.1063
   Wen W, 2004, STROKE, V35, P2813, DOI 10.1161/01.STR.0000147034.25760.3d
   Wen W, 2009, HUM BRAIN MAPP, V30, P1155, DOI 10.1002/hbm.20586
   Winblad B, 2004, J INTERN MED, V256, P240, DOI 10.1111/j.1365-2796.2004.01380.x
   YESAVAGE JA, 1983, J PSYCHIATR RES, V17, P37, DOI 10.1016/0022-3956(82)90033-4
NR 82
TC 273
Z9 273
U1 1
U2 8
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1041-6102
EI 1741-203X
J9 INT PSYCHOGERIATR
JI Int. Psychogeriatr.
PD DEC
PY 2010
VL 22
IS 8
BP 1248
EP 1264
DI 10.1017/S1041610210001067
PG 17
WC Psychology, Clinical; Geriatrics & Gerontology; Gerontology; Psychiatry;
   Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Geriatrics & Gerontology; Psychiatry
GA 678AO
UT WOS:000284039700008
PM 20637138
OA hybrid
DA 2025-06-11
ER

PT J
AU Seo, MW
   Gann, J
   Lee, JM
   Heffernan, KS
   Kim, JY
   Jung, HC
AF Seo, Myong-Won
   Gann, Joshua
   Lee, Jung-Min
   Heffernan, Kevin S. S.
   Kim, Joon Young
   Jung, Hyun Chul
TI Potential impact of metabolic syndrome on cognitive function in US
   firefighters
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE firefighter health; occupational risk; cardiometabolic disease risk;
   cognitive health; line-of-duty deaths
ID INSULIN-RESISTANCE; CARDIORESPIRATORY FITNESS; HEALTH; PREVALENCE;
   PREDICTORS; OBESITY; RISKS; AGE
AB ObjectivesAmong US firefighters, sudden cardiac arrest and psychological stress (i.e., PTSD) are the leading cause of on-duty death. Metabolic syndrome (MetSyn) may influence both cardiometabolic and cognitive health. Here, we examined differences in cardiometabolic disease risk factors, cognitive function, and physical fitness in US firefighters with vs. without MetSyn. Materials and methodsOne hundred fourteen male firefighters, aged 20 to 60 years, participated in the study. US firefighters with MetSyn vs. non-MetSyn were divided by AHA/NHLBI criteria. Of them, we performed a paired-match analysis with respect to the age and BMI of firefighters with (n = 18) vs. without MetSyn (n = 18). The cardiometabolic disease risk factors included blood pressure, fasting glucose, blood lipid profiles [HDL-C, triglyceride (TG)], and surrogate markers of insulin resistance [TG/HDL-C, TG glucose index (TyG)]. The cognitive test included a psychomotor vigilance task as a measure of reaction time and a delayed-match-to-sample task (DMS) as a measure of memory, using the computer-based Psychological Experiment Building Language Version 2.0 program. The differences between MetSyn and non-MetSyn groups in US firefighters were analyzed using an independent t-test adjusted for age and BMI. In addition, Spearman correlation and stepwise multiple regression were conducted. ResultsUS firefighters with MetSyn exhibited severe insulin resistance estimated by TG/HDL-C and TyG (Cohen's d > 0.8, all p < 0.01) compared with their age- and BMI-matched counterparts without MetSyn. In addition, US firefighters with MetSyn exhibited higher DMS total time and reaction time compared with non-MetSyn (Cohen's d > 0.8, all p < 0.01). In stepwise linear regression, HDL-C predicted DMS total time (beta = - 0.440, R-2 = 0.194, p < 0.05), and TyG (beta = 0.432, R-2 = 0.186, p < 0.05) predicted DMS reaction time. ConclusionUS firefighters with vs. without MetSyn were predisposed to metabolic risk factors, surrogate markers of insulin resistance, and cognitive function, even when matched for age and BMI, and there was a negative association between metabolic characteristics and cognitive function in US firefighters. The findings of this study suggest that the prevention of MetSyn may be beneficial to supporting firefighters' safety and occupational performance.
C1 [Seo, Myong-Won; Heffernan, Kevin S. S.; Kim, Joon Young] Syracuse Univ, David B Falk Coll Sports & Human Dynam, Dept Exercise Sci, Syracuse, NY USA.
   [Gann, Joshua] Univ Louisiana Monroe, Sch Allied Hlth, Dept Kinesiol, Monroe, LA USA.
   [Lee, Jung-Min; Jung, Hyun Chul] Kyung Hee Univ, Sports Sci Res Ctr, Yongin, South Korea.
   [Lee, Jung-Min] Kyung Hee Univ, Coll Phys Educ, Dept Phys Educ, Yongin, South Korea.
   [Jung, Hyun Chul] Kyung Hee Univ, Coll Phys Educ, Dept Sports Coaching, Yongin, South Korea.
C3 Syracuse University; University of Louisiana System; University of
   Louisiana Monroe; Kyung Hee University; Kyung Hee University; Kyung Hee
   University
RP Jung, HC (corresponding author), Kyung Hee Univ, Sports Sci Res Ctr, Yongin, South Korea.; Jung, HC (corresponding author), Kyung Hee Univ, Coll Phys Educ, Dept Sports Coaching, Yongin, South Korea.
EM jhc@khu.ac.kr
RI Kim, Joon/I-9690-2016; Jung, Hyun/AAI-8359-2020; Lee,
   Jung-Min/L-8227-2016
OI Seo, Myong-Won/0000-0001-8545-4711; Kim, Joon Young/0000-0003-0448-1684;
   Lee, Jung-Min/0000-0002-8033-0725
CR Aisbett B, 2012, APPL ERGON, V43, P916, DOI 10.1016/j.apergo.2011.12.013
   Bastardot F, 2019, INT J OBESITY, V43, P1026, DOI 10.1038/s41366-018-0218-7
   Bates KA, 2017, INT J NEUROSCI, V127, P243, DOI 10.1080/00207454.2016.1182527
   Baur DM, 2012, J STRENGTH COND RES, V26, P2331, DOI 10.1519/JSC.0b013e31823e9b19
   Beekley MD, 2004, RES Q EXERCISE SPORT, V75, P337, DOI 10.1080/02701367.2004.10609165
   Campbell R., 2021, US FIREFIGHTER INJUR
   Canetti EFD, 2022, BIOLOGY-BASEL, V11, DOI 10.3390/biology11010104
   Carey MG, 2011, J CARDIOVASC NURS, V26, P298, DOI 10.1097/JCN.0b013e31820344d7
   Crichton GE, 2014, J INT NEUROPSYCH SOC, V20, P961, DOI 10.1017/S1355617714000885
   Demerath EW, 2008, AM J CLIN NUTR, V88, P1263, DOI 10.3945/ajcn.2008.26546
   Donovan R, 2009, OCCUP MED-OXFORD, V59, P487, DOI 10.1093/occmed/kqp095
   Ebron K, 2015, METAB SYNDR RELAT D, V13, P458, DOI 10.1089/met.2015.0053
   Geibe JR, 2008, AM J CARDIOL, V101, P585, DOI 10.1016/j.amjcard.2007.10.017
   Giersch GEW, 2022, EXP PHYSIOL, V107, P1136, DOI 10.1113/EP090402
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Guicciardi M, 2019, FRONT PSYCHOL, V10, DOI 10.3389/fpsyg.2019.01845
   Hales Craig M, 2020, NCHS Data Brief, P1, DOI 10.21608/seaf.2020.162168
   He Q, 2016, LIPIDS HEALTH DIS, V15, DOI 10.1186/s12944-016-0320-6
   Hemmatjo R, 2020, ANN GLOB HEALTH, V86, DOI 10.5334/aogh.2626
   Hess PL, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.117.006103
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Hwang J, 2017, PHYSIOL BEHAV, V179, P75, DOI 10.1016/j.physbeh.2017.05.011
   Kinno R, 2019, NEUROIMAGE-CLIN, V22, DOI 10.1016/j.nicl.2019.101746
   Kuk JL, 2010, DIABETES CARE, V33, P2457, DOI 10.2337/dc10-0942
   Kwak K, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17134647
   Li K, 2017, OCCUP MED-OXFORD, V67, P268, DOI 10.1093/occmed/kqx033
   Lind L, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-82398-8
   Maloney SR, 2021, J OCCUP ENVIRON MED, V63, P317, DOI 10.1097/JOM.0000000000002125
   McAllister MJ, 2023, J OCCUP ENVIRON MED, V65, P119, DOI 10.1097/JOM.0000000000002743
   Mehrdad R, 2013, INT J PREVENTIVE MED, V4, P1095
   Michaelides MA, 2011, J STRENGTH COND RES, V25, P956, DOI 10.1519/JSC.0b013e3181cc23ea
   Michaelides MA, 2008, RES Q EXERCISE SPORT, V79, P468, DOI 10.1080/02701367.2008.10599513
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   Mueller ST, 2014, J NEUROSCI METH, V222, P250, DOI 10.1016/j.jneumeth.2013.10.024
   Neergaard JS, 2017, DIABETES, V66, P1957, DOI 10.2337/db16-1444
   Noubiap JJ, 2022, DIABETES RES CLIN PR, V188, DOI 10.1016/j.diabres.2022.109924
   Poston WSC, 2011, J OCCUP ENVIRON MED, V53, P266, DOI 10.1097/JOM.0b013e31820af362
   Rastegar Z, 2022, HELIYON, V8, DOI 10.1016/j.heliyon.2021.e08698
   Siri W E, 1993, Nutrition, V9, P480
   Speakman JR, 2018, HAND CLINIC, V156, P431, DOI 10.1016/B978-0-444-63912-7.00026-6
   Storer TW, 2014, J STRENGTH COND RES, V28, P661, DOI 10.1519/JSC.0b013e31829b54da
   Superko HR, 2011, J OCCUP ENVIRON MED, V53, P758, DOI 10.1097/JOM.0b013e31821f64c3
   Willette AA, 2015, JAMA NEUROL, V72, P1013, DOI 10.1001/jamaneurol.2015.0613
   Xu DT, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17207689
   Yang J, 2013, AM J CARDIOL, V112, P1962, DOI 10.1016/j.amjcard.2013.08.029
   Zare S, 2018, ERGONOMICS, V61, P1334, DOI 10.1080/00140139.2018.1484524
NR 46
TC 4
Z9 4
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD MAY 25
PY 2023
VL 11
AR 1150121
DI 10.3389/fpubh.2023.1150121
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA I4DK6
UT WOS:001002298700001
PM 37304116
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kazakou, P
   Kyriazopoulou, V
   Michalaki, M
   Ierodiakonou, V
   Psyrogiannis, A
   Habeos, I
AF Kazakou, P.
   Kyriazopoulou, V.
   Michalaki, M.
   Ierodiakonou, V.
   Psyrogiannis, A.
   Habeos, I.
TI Activated Hypothalamic Pituitary Adrenal Axis in Patients with Metabolic
   Syndrome
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE ACTH; cortisol; metabolic syndrome; glucocorticoids
ID HOMEOSTASIS MODEL ASSESSMENT; INDUCED CORTISOL SECRETION; STRESS-INDUCED
   CORTISOL; BODY-FAT DISTRIBUTION; INSULIN-RESISTANCE; ORAL GLUCOSE;
   ABDOMINAL OBESITY; PLASMA-CORTISOL; WOMEN; FOOD
AB Metabolic syndrome (MetS) is correlated with the activity of hypothalamic-pituitary-adrenal axis (HPA), but the underlying mechanism still remains elusive. The aim of this study was to investigate the HPA axis function in patients with MetS. This case-control study included 159 people. They were divided into 2 groups. The first group included 73 healthy volunteers (control group: 19 males, 54 females, mean +/- SD: 49.9 +/- 7.5 years old, with BMI: 27.9 +/- 4.42 kg/m(2)) and the second group included 86 patients with MetS (case group: 48 males, 38 females, mean +/- SD: 52.2 +/- 7.6 years old, with BMI: 30.5 +/- 5.35 kg/m 2). An oral glucose tolerance test (OGTT) was performed for all subjects after a 12-h overnight fast, and blood samples were obtained for determination of ACTH, cortisol, insulin, C-peptide, and glucose levels. Serum cortisol after an overnight dexamethasone suppression test was determined in both groups. Patients with MetS had serum cortisol levels after an overnight dexamethasone suppression test significantly higher than controls. During OGTT plasma ACTH levels were higher at all time points in patients with MetS compared to controls, whereas serum cortisol levels were comparable between the 2 groups. Plasma ACTH during OGTT was also correlated with most of the components of MetS. The HPA axis in patients with MetS seems to be more active as evidenced by the higher cortisol levels after the overnight dexamethasone suppression test and by the higher ACTH levels during OGTT. This functional hypercortisolism might be involved in the pathogenesis of the metabolic syndrome.
C1 [Kazakou, P.; Kyriazopoulou, V.; Michalaki, M.; Ierodiakonou, V.; Psyrogiannis, A.; Habeos, I.] Univ Patras, Sch Med, Div Endocrine, Diabet Ctr,Internal Med Dept, GR-26110 Patras, Greece.
C3 University of Patras
RP Kyriazopoulou, V (corresponding author), Univ Patras, Sch Med, Div Endocrine, Diabet Ctr,Internal Med Dept, GR-26110 Patras, Greece.
EM vkyriazopoulou@med.upatras.gr
CR ALDAMLUJI S, 1987, CLIN ENDOCRINOL, V26, P629, DOI 10.1111/j.1365-2265.1987.tb00819.x
   Anagnostis P, 2009, J CLIN ENDOCR METAB, V94, P2692, DOI 10.1210/jc.2009-0370
   Andrews RC, 1999, CLIN SCI, V96, P513, DOI 10.1042/cs0960513
   Ascaso JF, 2003, DIABETES CARE, V26, P3320, DOI 10.2337/diacare.26.12.3320
   Bergman R, 2004, INT TXB DIABETES MEL, V16, P303
   Beuschlein F, 2000, CLIN ENDOCRINOL, V52, P617, DOI 10.1046/j.1365-2265.2000.01006.x
   Björntorp P, 1999, ANN NY ACAD SCI, V892, P297, DOI 10.1111/j.1749-6632.1999.tb07803.x
   Bonora E, 1998, DIABETES, V47, P1643, DOI 10.2337/diabetes.47.10.1643
   Cai ZJ, 1999, WHO TECH REP SER, V887, P1
   Cakir M, 2005, ENDOCR RES, V31, P213, DOI 10.1080/07435800500373199
   CHALEW S, 1995, OBES RES, V3, P371, DOI 10.1002/j.1550-8528.1995.tb00163.x
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   DINNEEN S, 1993, J CLIN INVEST, V92, P2283, DOI 10.1172/JCI116832
   Duclos M, 2005, OBES RES, V13, P1157, DOI 10.1038/oby.2005.137
   Duclos M, 2001, CLIN ENDOCRINOL, V55, P447, DOI 10.1046/j.1365-2265.2001.01384.x
   Epel EE, 1999, OBES RES, V7, P9, DOI 10.1002/j.1550-8528.1999.tb00385.x
   Epel ES, 2000, PSYCHOSOM MED, V62, P623, DOI 10.1097/00006842-200009000-00005
   FernandezReal JM, 1997, CLIN ENDOCRINOL, V47, P583, DOI 10.1046/j.1365-2265.1997.3351120.x
   FOLLENIUS M, 1982, J CLIN ENDOCR METAB, V55, P757, DOI 10.1210/jcem-55-4-757
   Fruehwald-Schultes B, 2001, INT J OBESITY, V25, pS38, DOI 10.1038/sj.ijo.0801695
   Gibson EL, 1999, PSYCHOSOM MED, V61, P214, DOI 10.1097/00006842-199903000-00014
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   HAUTANEN A, 1993, J INTERN MED, V234, P461, DOI 10.1111/j.1365-2796.1993.tb00779.x
   ISHIZUKA B, 1983, J CLIN ENDOCR METAB, V57, P1111, DOI 10.1210/jcem-57-6-1111
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   Korbonits M, 1996, CLIN ENDOCRINOL, V45, P699, DOI 10.1046/j.1365-2265.1996.8550865.x
   Leal AMO, 1997, BRAZ J MED BIOL RES, V30, P1391, DOI 10.1590/S0100-879X1997001200003
   Ljung T, 1996, OBES RES, V4, P277, DOI 10.1002/j.1550-8528.1996.tb00546.x
   Matsuda M, 1999, DIABETES CARE, V22, P1462, DOI 10.2337/diacare.22.9.1462
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Nakai Y, 2002, DIABETIC MED, V19, P346, DOI 10.1046/j.1464-5491.2002.00712_3.x
   Pasquali R, 2002, J CLIN ENDOCR METAB, V87, P166, DOI 10.1210/jc.87.1.166
   Pasquali R, 1998, CLIN ENDOCRINOL, V48, P603, DOI 10.1046/j.1365-2265.1998.00458.x
   Reynolds RM, 2001, J CLIN ENDOCR METAB, V86, P1149, DOI 10.1210/jc.86.3.1149
   Reynolds RM, 2003, METABOLISM, V52, P524, DOI 10.1053/meta.2003.50090
   RODMAN HM, 1973, METABOLISM, V21, P745, DOI 10.1016/0026-0495(73)90246-1
   Rosmond R, 1998, J CLIN ENDOCR METAB, V83, P1853, DOI 10.1210/jc.83.6.1853
   SOBER AJ, 1977, ACTA ENDOCRINOL-COP, V84, P115, DOI 10.1530/acta.0.0840115
   Vicennati V, 2004, J ENDOCRINOL INVEST, V27, P541, DOI 10.1007/BF03347476
   Vicennati V, 2002, J CLIN ENDOCR METAB, V87, P3984, DOI 10.1210/jc.87.8.3984
   Wajchenberg BL, 2000, ENDOCR REV, V21, P697, DOI 10.1210/er.21.6.697
NR 41
TC 17
Z9 20
U1 0
U2 5
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD OCT
PY 2012
VL 44
IS 11
BP 839
EP 844
DI 10.1055/s-0032-1311632
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 018IY
UT WOS:000309654800008
PM 22549399
DA 2025-06-11
ER

PT J
AU Sanghez, V
   Cubuk, C
   Sebastián-Leon, P
   Carobbio, S
   Dopazo, J
   Vidal-Puig, A
   Bartolomucci, A
AF Sanghez, Valentina
   Cubuk, Cankut
   Sebastian-Leon, Patricia
   Carobbio, Stefania
   Dopazo, Joaquin
   Vidal-Puig, Antonio
   Bartolomucci, Alessandro
TI Chronic subordination stress selectively downregulates the insulin
   signaling pathway in liver and skeletal muscle but not in adipose tissue
   of male mice
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Article
DE Adipose tissue; insulin; IRS1; IRS2; metabolic syndrome; obesity
ID HIGH-FAT-DIET; CHRONIC SOCIAL STRESS; PSYCHOSOCIAL STRESS; METABOLIC
   SYNDROME; INDUCED OBESITY; DIABETES-MELLITUS; VISCERAL OBESITY;
   ENERGY-BALANCE; MODEL; GLUCOCORTICOIDS
AB Chronic stress has been associated with obesity, glucose intolerance, and insulin resistance. We developed a model of chronic psychosocial stress (CPS) in which subordinate mice are vulnerable to obesity and the metabolic-like syndrome while dominant mice exhibit a healthy metabolic phenotype. Here we tested the hypothesis that the metabolic difference between subordinate and dominant mice is associated with changes in functional pathways relevant for insulin sensitivity, glucose and lipid homeostasis. Male mice were exposed to CPS for four weeks and fed either a standard diet or a high-fat diet (HFD). We first measured, by real-time PCR candidate genes, in the liver, skeletal muscle, and the perigonadal white adipose tissue (pWAT). Subsequently, we used a probabilistic analysis approach to analyze different ways in which signals can be transmitted across the pathways in each tissue. Results showed that subordinate mice displayed a drastic downregulation of the insulin pathway in liver and muscle, indicative of insulin resistance, already on standard diet. Conversely, pWAT showed molecular changes suggestive of facilitated fat deposition in an otherwise insulin-sensitive tissue. The molecular changes in subordinate mice fed a standard diet were greater compared to HFD-fed controls. Finally, dominant mice maintained a substantially normal metabolic and molecular phenotype even when fed a HFD. Overall, our data demonstrate that subordination stress is a potent stimulus for the downregulation of the insulin signaling pathway in liver and muscle and a major risk factor for the development of obesity, insulin resistance, and type 2 diabetes mellitus.
C1 [Sanghez, Valentina; Bartolomucci, Alessandro] Univ Minnesota, Dept Integrat Biol & Physiol, Minneapolis, MN USA.
   [Sanghez, Valentina] Univ Parma, Dept Neurosci, I-43100 Parma, Italy.
   [Cubuk, Cankut; Sebastian-Leon, Patricia; Dopazo, Joaquin] Ctr Invest Principe Felipe, Dept Computat Genom, Valencia, Spain.
   [Carobbio, Stefania; Vidal-Puig, Antonio] Univ Cambridge, Addenbrookes Hosp, Inst Metab Sci, Wellcome Trust MRC Metab Dis Unit, Cambridge CB2 2QQ, England.
   [Vidal-Puig, Antonio] Wellcome Trust Sanger Inst, Hinxton, England.
   [Sanghez, Valentina] Harbor UCLA Med Ctr, LABiomed Res Inst, Div Med Genet, Dept Pediat, Torrance, CA 90509 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Parma; Prince Felipe Research Center; Cambridge University
   Hospitals NHS Foundation Trust; Addenbrooke's Hospital; University of
   Cambridge; Wellcome Trust Sanger Institute; University of California
   System; University of California Los Angeles; University of California
   Los Angeles Medical Center
RP Bartolomucci, A (corresponding author), Univ Minnesota, Dept Integrat Biol & Physiol, Minneapolis, MN USA.
EM abartolo@umn.edu
RI carobbio, stefania/E-7095-2018; SEBASTIAN-LEON, PATRICIA/AAA-8009-2020;
   Dopazo, Joaquin/A-9270-2014; Bartolomucci, Alessandro/MFI-6219-2025
OI Sanghez, Valentina/0000-0002-4131-7480; SEBASTIAN-LEON,
   PATRICIA/0000-0001-7299-3660; CUBUK, Cankut/0000-0003-4646-0849;
   Bartolomucci, Alessandro/0000-0001-6439-8829; Vidal-Puig,
   Antonio/0000-0003-4220-9577
FU UofMN Medical School; Medical Research Council; MRC Disease Model Core;
   British Heart Foundation; Spanish Ministry of Economy and
   Competitiveness [BIO2011-27069]; GVA-FEDER [PROMETEOII/2014/025];
   University of Parma; EU [316861]; MRC [MC_UU_12012/2, G0802051,
   MC_G0802535] Funding Source: UKRI
FX This work is supported by UofMN Medical School startup funds to AB,
   Medical Research Council, MRC Disease Model Core and British Heart
   Foundation program grants to AVP, and BIO2011-27069 from the Spanish
   Ministry of Economy and Competitiveness and PROMETEOII/2014/025 from the
   GVA-FEDER to J.D. V.S. was supported by a graduate student fellowship of
   the University of Parma. C.C. was supported by EU FP7-People Project(ref
   316861) "MLPM2012: Machine Learning For Personalized Medicine".
CR Aldinger KA, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004729
   Alonso R, 2015, NUCLEIC ACIDS RES, V43, pW117, DOI 10.1093/nar/gkv384
   Amadoz A, 2015, SCI REP-UK, V5, DOI 10.1038/srep18494
   Bartolomucci A, 2005, NEUROSCI BIOBEHAV R, V29, P67, DOI 10.1016/j.neubiorev.2004.06.009
   Bartolomucci A, 2004, PSYCHONEUROENDOCRINO, V29, P899, DOI 10.1016/j.psyneuen.2003.08.003
   Bartolomucci A, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004331
   Bose M, 2009, CURR OPIN ENDOCRINOL, V16, P340, DOI 10.1097/MED.0b013e32832fa137
   BOUCHARD C, 1991, AM J CLIN NUTR, V53, pS1561, DOI 10.1093/ajcn/53.6.1561S
   Bruning JC, 1997, CELL, V88, P561, DOI 10.1016/S0092-8674(00)81896-6
   Buettner R, 2006, J MOL ENDOCRINOL, V36, P485, DOI 10.1677/jme.1.01909
   Cao JS, 2011, J BIOL CHEM, V286, P41838, DOI 10.1074/jbc.M111.245456
   Coccurello R, 2009, NEUROSCI BIOBEHAV R, V33, P537, DOI 10.1016/j.neubiorev.2008.05.018
   Dadomo H, 2011, PROG NEURO-PSYCHOPH, V35, P1461, DOI 10.1016/j.pnpbp.2010.11.016
   Dallman MF, 2006, PROG BRAIN RES, V153, P75, DOI 10.1016/S0079-6123(06)53004-3
   Dallman MF, 2010, TRENDS ENDOCRIN MET, V21, P159, DOI 10.1016/j.tem.2009.10.004
   DALLMAN MF, 1993, FRONT NEUROENDOCRIN, V14, P303, DOI 10.1006/frne.1993.1010
   de Jong JMA, 2015, AM J PHYSIOL-ENDOC M, V308, pE1085, DOI 10.1152/ajpendo.00023.2015
   Finger BC, 2012, PSYCHONEUROENDOCRINO, V37, P729, DOI 10.1016/j.psyneuen.2011.06.015
   Fisher JP, 2009, AUTON NEUROSCI-BASIC, V148, P5, DOI 10.1016/j.autneu.2009.02.003
   Forman BM, 1996, ANN NY ACAD SCI, V804, P266, DOI 10.1111/j.1749-6632.1996.tb18621.x
   Gesquiere LR, 2011, SCIENCE, V333, P357, DOI 10.1126/science.1207120
   Guillam MT, 1997, NAT GENET, V17, P327, DOI 10.1038/ng1197-327
   Harris RBS, 2015, AM J PHYSIOL-REG I, V308, pR250, DOI 10.1152/ajpregu.00361.2014
   Hernansaiz-Ballesteros RD, 2015, NUCLEIC ACIDS RES, V43, pW270, DOI 10.1093/nar/gkv349
   Kahn RC, 1994, DIABETES, V43, P1066
   Karasawa H, 2009, METABOLISM, V58, P296, DOI 10.1016/j.metabol.2008.09.028
   Koolhaas JM, 2011, NEUROSCI BIOBEHAV R, V35, P1291, DOI 10.1016/j.neubiorev.2011.02.003
   Kuo LE, 2007, NAT MED, V13, P803, DOI 10.1038/nm1611
   Kyrou I, 2006, ANN NY ACAD SCI, V1083, P77, DOI 10.1196/annals.1367.008
   Lewis GF, 2002, ENDOCR REV, V23, P201, DOI 10.1210/er.23.2.201
   Mackenbach JP, 1997, LANCET, V349, P1655, DOI 10.1016/S0140-6736(96)07226-1
   McGarry JD, 2002, DIABETES, V51, P7, DOI 10.2337/diabetes.51.1.7
   Moles A, 2006, PSYCHONEUROENDOCRINO, V31, P623, DOI 10.1016/j.psyneuen.2006.01.004
   OLEFSKY JM, 1982, AM J PHYSIOL, V243, pE15, DOI 10.1152/ajpendo.1982.243.1.E15
   Pfaffl MW, 2004, BIOTECHNOL LETT, V26, P509, DOI 10.1023/B:BILE.0000019559.84305.47
   Razzoli M., 2015, Front. Nutr, V1
   Razzoli M, 2016, MOL METAB, V5, P19, DOI 10.1016/j.molmet.2015.10.005
   Razzoli M, 2015, GENES NUTR, V10, DOI 10.1007/s12263-015-0458-2
   Rosmond R, 1998, J CLIN ENDOCR METAB, V83, P1853, DOI 10.1210/jc.83.6.1853
   Sanghez V, 2013, PSYCHONEUROENDOCRINO, V38, P2933, DOI 10.1016/j.psyneuen.2013.07.022
   Sapolsky RM, 2005, SCIENCE, V308, P648, DOI 10.1126/science.1106477
   Sapolsky RM, 2000, ENDOCR REV, V21, P55, DOI 10.1210/er.21.1.55
   Scott KA, 2012, CURR OBES REP, V1, DOI 10.1007/s13679-011-0006-3
   Sebastián D, 2009, J LIPID RES, V50, P1789, DOI 10.1194/jlr.M800535-JLR200
   Sebastian-Leon P, 2014, BMC SYST BIOL, V8, DOI 10.1186/s12918-014-0121-3
   Sebastián-León P, 2013, NUCLEIC ACIDS RES, V41, pW213, DOI 10.1093/nar/gkt451
   Shirakami A, 2002, J ENDOCRINOL, V174, DOI 10.1677/joe.0.1740309
   Shively CA, 2009, AM J PRIMATOL, V71, P742, DOI 10.1002/ajp.20706
   Shpilberg Y, 2012, DIS MODEL MECH, V5, P671, DOI 10.1242/dmm.008912
   Stumvoll M, 2005, LANCET, V365, P1333, DOI 10.1016/S0140-6736(05)61032-X
   SURWIT RS, 1988, DIABETES, V37, P1163, DOI 10.2337/diabetes.37.9.1163
   Taniguchi CM, 2006, NAT REV MOL CELL BIO, V7, P85, DOI 10.1038/nrm1837
   Thorens B, 2000, J BIOL CHEM, V275, P23751, DOI 10.1074/jbc.M002908200
   VANSTRIEN T, 1986, INT J OBESITY, V10, P29
   Virtue S, 2010, BBA-MOL CELL BIOL L, V1801, P338, DOI 10.1016/j.bbalip.2009.12.006
   Winzell MS, 2004, DIABETES, V53, pS215, DOI 10.2337/diabetes.53.suppl_3.S215
   Withers DJ, 1998, NATURE, V391, P900, DOI 10.1038/36116
NR 57
TC 9
Z9 11
U1 0
U2 13
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1025-3890
EI 1607-8888
J9 STRESS
JI Stress
PD MAR
PY 2016
VL 19
IS 2
BP 214
EP 224
DI 10.3109/10253890.2016.1151491
PG 11
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA DK1GA
UT WOS:000374659300010
PM 26946982
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Anderson, RA
AF Anderson, Richard A.
TI Chromium and polyphenols from cinnamon improve insulin sensitivity
SO PROCEEDINGS OF THE NUTRITION SOCIETY
LA English
DT Article; Proceedings Paper
CT Summer Meeting of the Nutrition-Society
CY JUL 16-19, 2007
CL Univ Ulster, Coleraine, NORTH IRELAND
SP Nutr Soc Irish Sect
HO Univ Ulster
DE chromium; cinnamon polyphenols; insulin sensitivity; metabolic syndrome
ID CARCASS CHARACTERISTICS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   BLOOD-GLUCOSE; BODY-WEIGHT; SUPPLEMENTATION; PICOLINATE; EXTRACT;
   RESISTANCE; PERFORMANCE
AB Naturally-occurring compounds that have been shown to improve insulin sensitivity include Cr and polyphenols found in cinnamon (Cinnamomon cassia). These compounds also have similar effects on insulin signalling and glucose control. The signs of Cr deficiency are similar to those for the metabolic syndrome and supplemental Cr has been shown to improve all these signs in human subjects. In a double-blind placebo-controlled study it has been demonstrated that glucose, insulin, cholesterol and HbA1c are all improved in patients with type 2 diabetes following Cr supplementation. It has also been shown that cinnamon polyphenols improve insulin sensitivity in in vitro, animal and human studies. Cinnamon reduces mean fasting serum glucose (18-29%), TAG (23-30%), total cholesterol (12-26%) and LDL-cholesterol (7-27%) in subjects with type 2 diabetes after 40d of daily consumption of 1-6g cinnamon. Subjects with the metabolic syndrome who consume an aqueous extract of cinnamon have been shown to have improved fasting blood glucose, systolic blood pressure, percentage body fat and increased lean body mass compared with the placebo group. Studies utilizing an aqueous extract of cinnamon, high in type A polyphenols, have also demonstrated improvements in fasting glucose, glucose tolerance and insulin sensitivity in women with insulin resistance associated with the polycystic ovary syndrome. For both supplemental Cr and cinnamon not all studies have reported beneficial effects and the responses are related to the duration of the study, form of Cr or cinnamon used and the extent of obesity and glucose intolerance of the subjects.
C1 USDA, Beltsville Human Nutr Res Ctr, Beltsville, MD 20705 USA.
C3 United States Department of Agriculture (USDA)
RP Anderson, RA (corresponding author), USDA, Beltsville Human Nutr Res Ctr, Beltsville, MD 20705 USA.
EM Richard.anderson@irs.usda.gov
CR ANDERSON RA, 1991, EUR J APPL PHYSIOL O, V63, P146, DOI 10.1007/BF00235185
   Anderson RA, 2000, DIABETES METAB, V26, P22
   Anderson RA, 1998, J AM COLL NUTR, V17, P548, DOI 10.1080/07315724.1998.10718802
   Anderson RA, 1997, DIABETES, V46, P1786, DOI 10.2337/diabetes.46.11.1786
   Anderson RA, 1998, NUTR REV, V56, P266, DOI 10.1111/j.1753-4887.1998.tb01763.x
   Bayram Fahri, 2002, Treat Endocrinol, V1, P45, DOI 10.2165/00024677-200201010-00005
   Broadhurst CL, 2000, J AGR FOOD CHEM, V48, P849, DOI 10.1021/jf9904517
   Bulbulian R, 1996, MED SCI SPORT EXER, V28, P1336, DOI 10.1097/00005768-199610000-00020
   Cao HP, 2007, ARCH BIOCHEM BIOPHYS, V459, P214, DOI 10.1016/j.abb.2006.12.034
   Cefalu WT, 2004, DIABETES CARE, V27, P2741, DOI 10.2337/diacare.27.11.2741
   Cusi K, 2000, J CLIN INVEST, V105, P311, DOI 10.1172/JCI7535
   Frank A, 2000, SCI TOTAL ENVIRON, V249, P133, DOI 10.1016/S0048-9697(99)00517-3
   FREEDMAN MR, 1986, AM J PHYSIOL, V250, pR595, DOI 10.1152/ajpregu.1986.250.4.R595
   Ghosh D, 2002, J NUTR BIOCHEM, V13, P690, DOI 10.1016/S0955-2863(02)00220-6
   Grundy SM, 2006, J AM COLL CARDIOL, V47, P1093, DOI 10.1016/j.jacc.2005.11.046
   Hlebowicz J, 2007, AM J CLIN NUTR, V85, P1552, DOI 10.1093/ajcn/85.6.1552
   Imparl-Radosevich J, 1998, HORM RES, V50, P177, DOI 10.1159/000023270
   Jarvill-Taylor KJ, 2001, J AM COLL NUTR, V20, P327, DOI 10.1080/07315724.2001.10719053
   Khan A, 2003, DIABETES CARE, V26, P3215, DOI 10.2337/diacare.26.12.3215
   KHAN A, 1990, BIOL TRACE ELEM RES, V24, P183, DOI 10.1007/BF02917206
   Kobla HV, 2000, CRIT REV FOOD SCI, V40, P291, DOI 10.1080/10408690091189167
   LINDEMANN MD, 1995, J ANIM SCI, V73, P457
   Lucidi RS, 2005, FERTIL STERIL, V84, P1755, DOI 10.1016/j.fertnstert.2005.06.028
   Mang B, 2006, EUR J CLIN INVEST, V36, P340, DOI 10.1111/j.1365-2362.2006.01629.x
   Martin J, 2006, DIABETES CARE, V29, P1826, DOI 10.2337/dc06-0254
   Matsuda M, 1999, DIABETES CARE, V22, P1462, DOI 10.2337/diacare.22.9.1462
   Mooney KW, 1999, J ANIM SCI, V77, P1188
   National Cholesterol Education Program Expert Panel on Detection Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III), 2002, CIRCULATION, V106, P3143
   PAGE TG, 1993, J ANIM SCI, V71, P656, DOI 10.2527/1993.713656x
   Pattar GR, 2006, MUTAT RES-GEN TOX EN, V610, P93, DOI 10.1016/j.mrgentox.2006.06.018
   Pittler MH, 2003, INT J OBESITY, V27, P522, DOI 10.1038/sj.ijo.0802262
   Qiao Q, 2007, ANN CLIN BIOCHEM, V44, P232, DOI 10.1258/000456307780480963
   Qin B, 2004, HORM METAB RES, V36, P119, DOI 10.1055/s-2004-814223
   Qin BL, 2003, DIABETES RES CLIN PR, V62, P139, DOI 10.1016/S0168-8227(03)00173-6
   Rabinovitz H, 2004, INT J VITAM NUTR RES, V74, P178, DOI 10.1024/0300-9831.74.3.178
   Robertson RP, 2004, J BIOL CHEM, V279, P42351, DOI 10.1074/jbc.R400019200
   Roussel A, 2006, J Am Coll Nutr, V25, P443
   STRACK AM, 1995, AM J PHYSIOL-REG I, V268, pR142, DOI 10.1152/ajpregu.1995.268.1.R142
   Vanschoonbeek K, 2006, J NUTR, V136, P977, DOI 10.1093/jn/136.4.977
   Vincent JB, 2003, SPORTS MED, V33, P213, DOI 10.2165/00007256-200333030-00004
   Vrtovec M, 2005, AM HEART J, V149, P632, DOI 10.1016/j.ahj.2004.07.021
   Wang JG, 2007, FERTIL STERIL, V88, P240, DOI 10.1016/j.fertnstert.2006.11.082
   Wang MQ, 2004, ASIAN AUSTRAL J ANIM, V17, P1118, DOI 10.5713/ajas.2004.1118
   Yu YX, 2005, AM J MED SCI, V330, P227, DOI 10.1097/00000441-200511000-00005
   Ziegenfuss TN, 2006, J INT SOC SPORT NUTR, V3, DOI 10.1186/1550-2783-3-2-45
NR 45
TC 105
Z9 136
U1 1
U2 45
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0029-6651
EI 1475-2719
J9 P NUTR SOC
JI Proc. Nutr. Soc.
PD FEB
PY 2008
VL 67
IS 1
BP 48
EP 53
DI 10.1017/S0029665108006010
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics
GA 265QE
UT WOS:000253375200006
PM 18234131
OA Bronze
DA 2025-06-11
ER

PT J
AU Ohno, Y
   Miyoshi, T
   Noda, Y
   Oe, H
   Toh, N
   Nakamura, K
   Kohno, K
   Morita, H
   Ito, H
AF Ohno, Yuko
   Miyoshi, Toru
   Noda, Yoko
   Oe, Hiroki
   Toh, Norihisa
   Nakamura, Kazufumi
   Kohno, Kunihisa
   Morita, Hiroshi
   Ito, Hiroshi
TI Bezafibrate improves postprandial hypertriglyceridemia and associated
   endothelial dysfunction in patients with metabolic syndrome: a
   randomized crossover study
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Atherosclerosis; Bezafibrate; Triglyceride; Endothelium; Vasodilation
ID CORONARY-ARTERY-DISEASE; TYPE-2 DIABETES-MELLITUS; NONFASTING
   TRIGLYCERIDES; ATHEROSCLEROTIC PLAQUES; MYOCARDIAL-INFARCTION; SECONDARY
   PREVENTION; OXIDATIVE STRESS; STATIN THERAPY; HEART-DISEASE; CHOLESTEROL
AB Background: Postprandial elevation of triglyceride-rich lipoproteins impairs endothelial function, which can initiate atherosclerosis. We investigated the effects of bezafibrate on postprandial endothelial dysfunction and lipid profiles in patients with metabolic syndrome.
   Methods: Ten patients with metabolic syndrome were treated with 400 mg/day bezafibrate or untreated for 4 weeks in a randomized crossover study. Brachial artery flow-mediated dilation (FMD) and lipid profiles were assessed during fasting and after consumption of a standardized snack. Serum triglyceride and cholesterol contents of lipoprotein fractions were analyzed by high-performance liquid chromatography.
   Results: Postprandial FMD decreased significantly and reached its lowest value 4 h after the cookie test in both the bezafibrate and control groups, but the relative change in FMD from baseline to minimum in the bezafibrate group was significantly smaller than that in the control group (-29.0 +/- 5.9 vs. -42.9 +/- 6.2 %, p = 0.04). Bezafibrate significantly suppressed postprandial elevation of triglyceride (incremental area under the curve (AUC): 544 +/- 65 vs. 1158 +/- 283 mg h/dl, p = 0.02) and remnant lipoprotein cholesterol (incremental AUC: 27.9 +/- 3.5 vs. 72.3 +/- 14.1 mg h/dl, p < 0.01). High-performance liquid chromatography analysis revealed that postprandial triglyceride content of the chylomicron and very low-density lipoprotein fractions was significantly lower in the bezafibrate group than in the control group (p < 0.05).
   Conclusion: Bezafibrate significantly decreased postprandial endothelial dysfunction, and elevations of both exogenous and endogenous triglycerides in patients with metabolic syndrome, suggesting that bezafibrate may have vascular protective effects in these patients.
C1 [Ohno, Yuko; Noda, Yoko; Toh, Norihisa; Nakamura, Kazufumi; Kohno, Kunihisa; Morita, Hiroshi; Ito, Hiroshi] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Cardiovasc Med, Okayama 7008558, Japan.
   [Miyoshi, Toru] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Cardiovasc Therapeut, Okayama 7008558, Japan.
   [Oe, Hiroki] Okayama Univ Hosp, Ctr Ultrason Diagnost, Okayama, Japan.
C3 Okayama University; Okayama University; Okayama University
RP Miyoshi, T (corresponding author), Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Cardiovasc Therapeut, 2-5-1 Shikata Cho, Okayama 7008558, Japan.
EM miyoshit@cc.okayama-u.ac.jp
RI ohno, yuko/IWD-7759-2023
OI Nakamura, Kazufumi/0000-0001-8845-3626
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Attia N, 2000, ATHEROSCLEROSIS, V149, P427, DOI 10.1016/S0021-9150(99)00337-8
   Bae JH, 2001, ATHEROSCLEROSIS, V155, P517, DOI 10.1016/S0021-9150(00)00601-8
   Bansal S, 2007, JAMA-J AM MED ASSOC, V298, P309, DOI 10.1001/jama.298.3.309
   Botham KM, 2013, PROG LIPID RES, V52, P446, DOI 10.1016/j.plipres.2013.06.001
   Cannon CP, 2006, J AM COLL CARDIOL, V48, P438, DOI 10.1016/j.jacc.2006.04.070
   Corretti MC, 2002, J AM COLL CARDIOL, V39, P257, DOI 10.1016/S0735-1097(01)01746-6
   Evans M, 2000, CIRCULATION, V101, P1773, DOI 10.1161/01.CIR.101.15.1773
   Garlanda C, 2005, ANNU REV IMMUNOL, V23, P337, DOI 10.1146/annurev.immunol.23.021704.115756
   Goldenberg I, 2009, AM J CARDIOL, V103, P41, DOI 10.1016/j.amjcard.2008.08.033
   Harano Y, 2006, ENDOCR J, V53, P173, DOI 10.1507/endocrj.53.173
   HELLER F, 1983, EUR J CLIN PHARMACOL, V25, P57, DOI 10.1007/BF00544015
   Jukema JW, 2012, J AM COLL CARDIOL, V60, P875, DOI 10.1016/j.jacc.2012.07.007
   Krysiak R, 2011, J CLIN PHARMACOL, V51, P1459, DOI 10.1177/0091270010382914
   Meco JF, 2001, J CARDIOVASC PHARM, V38, P250, DOI 10.1097/00005344-200108000-00011
   Murakami H, 2006, BIOCHEM BIOPH RES CO, V341, P973, DOI 10.1016/j.bbrc.2006.01.052
   Nakamura T, 2005, ATHEROSCLEROSIS, V181, P321, DOI 10.1016/j.atherosclerosis.2005.01.012
   Takamitsu NA, 2008, CLIN CHIM ACTA, V390, P38, DOI 10.1016/j.cca.2007.12.012
   Norata GD, 2007, ATHEROSCLEROSIS, V193, P321, DOI 10.1016/j.atherosclerosis.2006.09.015
   Nordestgaard BG, 2007, JAMA-J AM MED ASSOC, V298, P299, DOI 10.1001/jama.298.3.299
   Olijhoek JK, 2008, J CARDIOVASC PHARM, V52, P145, DOI 10.1097/FJC.0b013e31817ffe76
   Pauciullo P, 2000, ATHEROSCLEROSIS, V150, P429, DOI 10.1016/S0021-9150(00)00379-8
   Rolph MS, 2002, ARTERIOSCL THROM VAS, V22, pE10, DOI 10.1161/01.ATV.0000015595.95497.2F
   Rosenson RS, 2007, DIABETES CARE, V30, P1945, DOI 10.2337/dc07-0015
   Sandoval JC, 2010, J ATHEROSCLER THROMB, V17, P610, DOI 10.5551/jat.3988
   Schlesinger Z, 2000, CIRCULATION, V102, P21, DOI 10.1161/01.CIR.102.1.21
   Suzuki S, 2008, AM HEART J, V155, P75, DOI 10.1016/j.ahj.2007.08.013
   Tenenbaum A, 2005, EUR HEART J, V26, P2032, DOI 10.1093/eurheartj/ehi310
   Tenenbaum A, 2005, ARCH INTERN MED, V165, P1154, DOI 10.1001/archinte.165.10.1154
   Tenenbaum A, 2004, CIRCULATION, V109, P2197, DOI 10.1161/01.CIR.0000126824.12785.B6
   Tenenbaum A, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-140
   Tenenbaum A, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-125
   Tenenbaum A, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035298
   Teramoto T, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-29
   Triolo M, 2014, EUR J CLIN INVEST, V44, P240, DOI 10.1111/eci.12226
   Usui S, 2002, J LIPID RES, V43, P805
   van Oostrom AJHHM, 2003, J LIPID RES, V44, P576, DOI 10.1194/jlr.M200419-JLR200
   Wang TY, 2013, EUR J CLIN INVEST, V43, P1203, DOI 10.1111/eci.12161
   Wang Y, 2006, ATHEROSCLEROSIS, V187, P265, DOI 10.1016/j.atherosclerosis.2005.09.008
   Wilmink HW, 2001, CARDIOVASC RES, V50, P577, DOI 10.1016/S0008-6363(01)00227-9
   Yunoki K, 2011, ATHEROSCLEROSIS, V217, P486, DOI 10.1016/j.atherosclerosis.2011.04.019
NR 41
TC 23
Z9 23
U1 0
U2 8
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD APR 5
PY 2014
VL 13
AR 71
DI 10.1186/1475-2840-13-71
PG 9
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA AF6FF
UT WOS:000334809100001
PM 24708775
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cruz, MME
   Sweetman, A
AF Meira e Cruz, Miguel
   Sweetman, Alexander
TI Comorbid Insomnia and Sleep Apnea: From Research to Clinical Practice
SO SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
LA English
DT Review; Early Access
DE comorbid insomnia and sleep apnea (COMISA); obstructive sleep apnea
   (OSA); insomnia; sleep disorders; cardiometabolic risk
ID CO-MORBID INSOMNIA; SYMPTOMS; PREVALENCE; MANAGEMENT; METAANALYSIS;
   ASSOCIATION; PREDICTORS; ADULTS; RISK; OSA
AB Comorbid insomnia and sleep apnea (COMISA) represents a highly prevalent and clinically significant overlap between the two most common sleep disorders: insomnia and obstructive sleep apnea (OSA). COMISA is associated with greater impairment in sleep, daytime functioning, and physical and mental health compared with insomnia or OSA alone. Despite its prevalence, COMISA has historically been underrecognized, partially due to the conflicting symptoms of insomnia (e.g., hyperarousal and sleeplessness) and OSA (e.g., sleep fragmentation and excessive daytime sleepiness). Recent research highlights that COMISA is not merely the coexistence of insomnia and OSA but may involve unique pathophysiological interactions and clinical phenotypes. This review explores the epidemiology, mechanisms, and clinical manifestations of COMISA. We examine insomnia as a potential extension of OSA, where repeated apneic events lead to conditioned hyperarousal, as well as OSA as an extension of chronic insomnia through mechanisms such as autonomic dysregulation and respiratory instability. Furthermore, we consider COMISA as a distinct entity, characterized by bidirectional interactions between the two conditions that exacerbate their clinical and physiological burden. Key challenges in diagnosing COMISA are discussed, including overlapping symptoms and limitations in current assessment tools. Emerging evidence suggests that COMISA is associated with increased cardiovascular and metabolic risks, greater mental health burden, and reduced treatment adherence to positive airway pressure (PAP) therapy. Advances in tailored therapeutic approaches, including combined cognitive-behavioral therapy for insomnia and OSA management strategies, are highlighted as promising avenues to improve outcomes. Understanding COMISA as a multidimensional condition with diverse phenotypes and mechanisms underscores the need for integrated diagnostic frameworks and personalized treatment strategies to optimize patient care. Further research into its unique features and long-term consequences is critical to advancing clinical practice in sleep and respiratory medicine.
C1 [Meira e Cruz, Miguel; Sweetman, Alexander] Univ Lisboa CCUL RISE, Lisbon Fac Med, Ctr Cardiovasc, Sleep Unit, Av Prof Egas Moniz, P-1649028 Lisbon, Portugal.
   [Meira e Cruz, Miguel; Sweetman, Alexander] Ctr Europeu Sono, Lisbon, Portugal.
   [Meira e Cruz, Miguel; Sweetman, Alexander] Flinders Univ S Australia, Adelaide Inst Sleep Hlth, Bedford Pk, SA, Australia.
C3 Universidade de Lisboa; Adelaide Institute for Sleep Health; Flinders
   University South Australia
RP Cruz, MME (corresponding author), Univ Lisboa CCUL RISE, Lisbon Fac Med, Ctr Cardiovasc, Sleep Unit, Av Prof Egas Moniz, P-1649028 Lisbon, Portugal.
EM mcruz@medicina.ulisboa.pt
RI Sweetman, Alexander/AAE-8541-2019
CR Abbott SBG, 2021, J PHYSIOL-LONDON, V599, P2559, DOI 10.1113/JP281305
   Abdelaziz A, 2024, J BEHAV MED, V47, P819, DOI 10.1007/s10865-024-00490-6
   Adams R., 2022, Sleep Epidemiol, V2, DOI [10.1016/j.sleepe.2022.100043, DOI 10.1016/J.SLEEPE.2022.100043]
   Alessi CA, 2021, SLEEP, V44, DOI 10.1093/sleep/zsaa235
   American Academy of Sleep Medicine, 2014, International Classification of Sleep Disorders. 3rd ed, V3
   Arnedt JT, 2021, SLEEP, V44, DOI 10.1093/sleep/zsaa136
   Bahia C, 2024, SLEEP MED, V115, P206
   Björnsdóttir E, 2013, SLEEP, V36, P1901, DOI 10.5665/sleep.3226
   Bjorvatn B, 2018, FRONT PSYCHOL, V9, DOI 10.3389/fpsyg.2018.02413
   Bjorvatn B, 2011, SCAND J PSYCHOL, V52, P580, DOI 10.1111/j.1467-9450.2011.00902.x
   Blaszczyk B, 2024, J CLIN MED, V13, DOI 10.3390/jcm13113154
   Bonsignore MR, 2024, EUR RESPIR REV, V33, DOI 10.1183/16000617.0166-2023
   Buysse DJ, 2011, ARCH INTERN MED, V171, P887, DOI 10.1001/archinternmed.2010.535
   Carter SG, 2021, SLEEP MED REV, V58, DOI 10.1016/j.smrv.2021.101492
   Cruz MME, 2023, J SLEEP RES, V32, DOI 10.1111/jsr.13705
   Cruz MME, 2021, SLEEP MED, V84, P283, DOI 10.1016/j.sleep.2021.05.043
   Edinger JD, 2021, J CLIN SLEEP MED, V17, P263, DOI 10.5664/jcsm.8988
   Engstrom M, 2013, J HEADACHE PAIN, V14, DOI 10.1186/1129-2377-14-12
   Fang FF, 2024, BMC GERIATR, V24, DOI 10.1186/s12877-024-05147-2
   Giannasi L., 2023, Sleep Sci, V16, P001
   Glidewell RN, 2014, SLEEP MED, V15, P899, DOI 10.1016/j.sleep.2014.05.001
   GUILLEMINAULT C, 1973, SCIENCE, V181, P856, DOI 10.1126/science.181.4102.856
   Hsieh CG, 2019, CURR SLEEP MED REP, V5, P234, DOI 10.1007/s40675-019-00157-8
   Ikeda K, 2017, J PHYSIOL SCI, V67, P45, DOI 10.1007/s12576-016-0475-y
   Kaczmarski P, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23169080
   Koffel EA, 2015, SLEEP MED REV, V19, P6, DOI 10.1016/j.smrv.2014.05.001
   Krakow B, 2001, CHEST, V120, P1923, DOI 10.1378/chest.120.6.1923
   Krakow B, 2012, SLEEP, V35, P1685, DOI 10.5665/sleep.2244
   Lechat B, 2022, NAT SCI SLEEP, V14, P1817, DOI 10.2147/NSS.S379252
   Lechat B, 2022, J SLEEP RES, V31, DOI 10.1111/jsr.13563
   Lechat B, 2022, EUR RESPIR J, V60, DOI 10.1183/13993003.01958-2021
   Lichstein KL, 1999, J CONSULT CLIN PSYCH, V67, P405, DOI 10.1037/0022-006X.67.3.405
   Lundetrae RS, 2021, FRONT PSYCHOL, V12, DOI 10.3389/fpsyg.2021.691495
   Luyster FS, 2010, J CLIN SLEEP MED, V6, P196
   Manetta IP, 2024, J CLIN SLEEP MED, V20, P1321, DOI 10.5664/jcsm.11138
   Maniaci A, 2024, J CARDIOVASC DEV DIS, V11, DOI 10.3390/jcdd11070204
   Cruz MME, 2024, SLEEP MED, V115, P165
   Cruz MME, 2022, SLEEP MED, V100, pS111
   Cruz MME, 2025, SLEEP, V48, DOI 10.1093/sleep/zsae306
   Cruz MME, 2025, ACTA MEDICA PORT, V38, P37, DOI 10.20344/amp.22350
   Cruz MME, 2021, SLEEP, V44, pA189
   Meira E Cruz Miguel, 2021, Sleep Vigil, V5, P333, DOI 10.1007/s41782-021-00163-3
   Cruz MME, 2021, AM J RESP CRIT CARE, V203, P1583, DOI 10.1164/rccm.202102-0337LE
   Mota PC, 2012, REV PORT PNEUMOL, V18, P15, DOI 10.1016/j.rppneu.2011.06.016
   NoelJorand MC, 1996, EUR J NEUROSCI, V8, P2075, DOI 10.1111/j.1460-9568.1996.tb00728.x
   O'Brien LM, 2017, SLEEP, V40, pA304, DOI 10.1093/sleepj/zsx050.820
   Ong JC, 2020, SLEEP, V43, DOI 10.1093/sleep/zsaa041
   Ou YH, 2024, J AM COLL CARDIOL, V83, P1760, DOI 10.1016/j.jacc.2024.03.359
   Papatriantafyllou E, 2022, NUTRIENTS, V14, DOI 10.3390/nu14081549
   Ree M, 2017, SLEEP MED, V36, pS43, DOI 10.1016/j.sleep.2017.03.017
   Schutte-Rodin S, 2008, J CLIN SLEEP MED, V4, P487
   Sweetman A., 2024, Front Sleep, V3
   Sweetman A, 2024, INTERN MED J, V54, P1838, DOI 10.1111/imj.16521
   Sweetman A, 2023, AUST J GEN PRACT, V52, P691, DOI 10.31128/AJGP-01-23-6678
   Sweetman A, 2023, AUST J GEN PRACT, V52, P607, DOI 10.31128/AJGP-12-22-6648
   Sweetman A, 2023, J SLEEP RES, V32, DOI 10.1111/jsr.13847
   Sweetman A, 2022, SLEEP MED CLIN, V17, P597, DOI 10.1016/j.jsmc.2022.07.006
   Sweetman A, 2021, SLEEP MED REV, V60, DOI 10.1016/j.smrv.2021.101519
   Sweetman A, 2021, SLEEP MED, V82, P9, DOI 10.1016/j.sleep.2021.03.023
   Sweetman A, 2021, SLEEP MED REV, V56, DOI 10.1016/j.smrv.2020.101404
   Sweetman A, 2020, ERJ OPEN RES, V6, DOI 10.1183/23120541.00161-2020
   Sweetman A, 2020, SLEEP, V43, DOI 10.1093/sleep/zsaa002
   Sweetman A, 2019, BRAIN SCI, V9, DOI 10.3390/brainsci9120371
   Sweetman A, 2019, SLEEP, V42, DOI 10.1093/sleep/zsz178
   Sweetman AM, 2017, SLEEP MED REV, V33, P28, DOI 10.1016/j.smrv.2016.04.004
   Torres G, 2024, CLIN INVEST ARTERIOS, V36, P234, DOI 10.1016/j.arteri.2024.01.004
   Turner AD, 2023, SLEEP, V46, DOI 10.1093/sleep/zsad128
   van der Zweerde T, 2019, SLEEP MED REV, V48, DOI 10.1016/j.smrv.2019.08.002
   Wallace DM, 2019, J CLIN SLEEP MED, V15, P1827, DOI 10.5664/jcsm.8094
   Yanagimori M, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-34002-4
   Yelov L, 2024, J CLIN SLEEP MED, V20, P245, DOI 10.5664/jcsm.10834
   Zhang Y, 2019, SLEEP MED REV, V45, P1, DOI 10.1016/j.smrv.2019.01.004
NR 72
TC 0
Z9 0
U1 0
U2 0
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1069-3424
EI 1098-9048
J9 SEMIN RESP CRIT CARE
JI Semin. Respir. Crit. Care Med.
PD 2025 MAY 30
PY 2025
DI 10.1055/a-2591-5664
EA MAY 2025
PG 12
WC Critical Care Medicine; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Respiratory System
GA 3FY9I
UT WOS:001499421500001
PM 40258387
DA 2025-06-11
ER

PT J
AU Rahbardar, MG
   Kakhki, HF
   Hosseinzadeh, H
AF Rahbardar, Mahboobeh Ghasemzadeh
   Kakhki, Homa Fazeli
   Hosseinzadeh, Hossein
TI Ziziphus jujuba (Jujube) in Metabolic Syndrome: From Traditional
   Medicine to Scientific Validation
SO CURRENT NUTRITION REPORTS
LA English
DT Review
DE Antioxidants; Hypoglycemic Agents; Phytochemicals; Anti-Inflammatory
   Agents; Betulinic Acid; Lupeol
ID ENDOTHELIUM-DEPENDENT RELAXATION; TYPE-2 DIABETIC-PATIENTS; BETULINIC
   ACID; OXIDATIVE STRESS; INSULIN-RESISTANCE; ADIPOSE-TISSUE;
   CARDIOVASCULAR-RESPONSES; THERAPEUTIC TARGET; LIPID-ACCUMULATION;
   ETHYL-ACETATE
AB Purpose of Review This review evaluates the therapeutic potential of Ziziphus jujuba and its main components in managing complications of metabolic syndrome, including diabetes, dyslipidemia, obesity, and hypertension. Recent Findings The reviewed studies provide evidence supporting the use of Z. jujuba and its main components (lupeol and betulinic acid) as natural treatments for complications of metabolic syndrome. These substances enhance glucose uptake through the activation of signaling pathways such as phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), reduce hepatic glucose synthesis, and increase glucose uptake by adipocytes and skeletal muscle cells. They also improve insulin sensitivity by modulating AMP-activated protein kinase (AMPK) activity and regulating insulin signaling proteins and glucose transporters. In the field of dyslipidemia, they inhibit triglyceride synthesis, lipid accumulation, and adipogenic enzymes, while influencing key signaling pathways involved in adipogenesis. Z. jujuba and its constituents demonstrate anti-adipogenic effects, inhibiting lipid accumulation and modulating adipogenic enzymes and transcription factors. They also exhibit positive effects on endothelial function and vascular health by enhancing endothelial nitric oxide synthase (eNOS) expression, NO production, and antioxidant enzyme activity. Summary Z. jujuba, lupeol, and betulinic acid hold promise as natural treatments for complications of metabolic syndrome. They improve glucose metabolism, insulin sensitivity, and lipid profiles while exerting anti-adipogenic effects and enhancing endothelial function. However, further research is needed to elucidate the mechanisms and confirm their efficacy in clinical trials. These natural compounds offer potential as alternative therapies for metabolic disorders and contribute to the growing body of evidence supporting the use of natural medicines in their management.
C1 [Rahbardar, Mahboobeh Ghasemzadeh] Mashhad Univ Med Sci, Clin Res Inst, Transplant Res Ctr, Mashhad, Iran.
   [Kakhki, Homa Fazeli; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Iran.
   [Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Iran.; Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran.
EM hosseinzadehh@mums.ac.ir
RI Ghasemzadeh Rahbardar, Mahboobeh/V-4452-2019; Hosseinzadeh,
   Hossein/F-3013-2010
OI Hosseinzadeh, Hossein/0000-0002-3483-851X; Ghasemzadeh Rahbardar,
   Mahboobeh/0000-0002-5491-572X
FU Pharmaceutical Research Center
FX This work was supported by the Pharmaceutical Research Center and the
   Vice Chancellor of Research, at Mashhad University of Medical Sciences.
CR Abubakar O., 2013, ADV MED PLANT RES, V1, P249
   Afrisham R., 2015, J. Bot, V2015, P824683, DOI [10.1155/2015/824683, DOI 10.1155/2015/824683]
   Ahangarpour A, 2018, RES PHARM SCI, V13, P142, DOI 10.4103/1735-5362.223796
   Ajala-Lawal RA, 2020, ARCH PHYSIOL BIOCHEM, V126, P107, DOI 10.1080/13813455.2018.1498901
   Akhmedov AT., 2023, INT J MED SCI CLIN R, V3, P59
   Akshaya R., 2019, DRUG INVENT TODAY, V12, P777
   Al-Saeedi A. H., 2016, Pacific Science Review A: Natural Science and Engineering, V18, P78, DOI DOI 10.1016/J.PSRA.2016.09.001
   Ardakanian A, 2022, IRAN J BASIC MED SCI, V25, P198, DOI [10.22038/ijbms.2022.58734.13047, 10.22038/IJBMS.2022.58734.13047]
   Ardiansyah, 2012, BIOSCI BIOTECH BIOCH, V76, P183, DOI 10.1271/bbb.110559
   Baek JH, 2018, DIABETES METAB J, V42, P296, DOI 10.4093/dmj.2017.0106
   Bai L, 2017, FOOD FUNCT, V8, P816, DOI [10.1039/C6FO01690A, 10.1039/c6fo01690a]
   Bartels ED, 2015, CIRC RES, V117, P933, DOI 10.1161/CIRCRESAHA.115.307182
   Birgani GA, 2018, BRAZ J PHARM SCI, V54, DOI 10.1590/s2175-97902018000217171
   Bjornstad P, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1101-6
   Borén J, 2020, EUR HEART J, V41, P2313, DOI 10.1093/eurheartj/ehz962
   Brusotti G, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-05666-6
   Cerf Marlon E, 2013, Front Endocrinol (Lausanne), V4, P37, DOI 10.3389/fendo.2013.00037
   Chadt A, 2020, PFLUG ARCH EUR J PHY, V472, P1273, DOI 10.1007/s00424-020-02417-x
   Chait A, 2020, FRONT CARDIOVASC MED, V7, DOI 10.3389/fcvm.2020.00022
   Chen JP, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/3019568
   Chen JP, 2014, PHYTOTHER RES, V28, P1527, DOI 10.1002/ptr.5160
   Chen SD, 2022, MOLECULES, V27, DOI 10.3390/molecules27082517
   Choi YJ, 2013, J MED FOOD, V16, P2, DOI 10.1089/jmf.2012.2384
   Cojocaru KA, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12030658
   Coughlan KA, 2014, DIABET METAB SYND OB, V7, P241, DOI 10.2147/DMSO.S43731
   Rosa SCD, 2020, PHYSIOL REP, V8, DOI 10.14814/phy2.14607
   Daniel P, 2023, BIOINFORMATION, V19, P445, DOI 10.6026/97320630019445
   de Melo CL, 2009, J AGR FOOD CHEM, V57, P8776, DOI 10.1021/jf900768w
   Deepika R., 2019, Drug Invent Today, V12, P1211
   Devi SK., 2019, DRUG INVENT TODAY, V12, P1188
   Dhivyadharshini A., 2019, DRUG INVENT TODAY, V12, P801
   Di Gioia M, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.626842
   Djeuzong E, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/5577163
   Duan GF, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1160069
   Elaloui M., 2016, International Journal of Secondary Metabolite, V4, P18, DOI [10.21448/ijsm.275886, DOI 10.21448/IJSM.275886]
   Emanuel AL, 2017, ARTERIOSCL THROM VAS, V37, P411, DOI 10.1161/ATVBAHA.116.308670
   Fadishei M, 2021, PHYTOTHER RES, V35, P2005, DOI 10.1002/ptr.6944
   Farhadnejad H, 2022, CLIN NUTR ESPEN, V49, P53, DOI 10.1016/j.clnesp.2022.03.043
   Feng J, 2020, DIABET METAB SYND OB, V13, P1399, DOI 10.2147/DMSO.S236127
   Frühbeck G, 2018, ADIPOCYTE, V7, P57, DOI 10.1080/21623945.2017.1402151
   Fu JY, 2011, EUR J PHARM SCI, V44, P385, DOI 10.1016/j.ejps.2011.08.025
   Gajapriya M., 2019, DRUG INVENT TODAY, V12, P516
   Galavi A, 2021, IRAN J BASIC MED SCI, V24, P3, DOI 10.22038/ijbms.2020.46956.10843
   Ghanbari M, 2021, INT IMMUNOPHARMACOL, V96, DOI 10.1016/j.intimp.2021.107765
   Ginsberg Henry N, 2009, J Cardiometab Syndr, V4, P113, DOI 10.1111/j.1559-4572.2008.00044.x
   Castro AJG, 2018, ARCH BIOCHEM BIOPHYS, V648, P20, DOI 10.1016/j.abb.2018.04.015
   Gong YL, 2023, J NUTR BIOCHEM, V122, DOI 10.1016/j.jnutbio.2023.109452
   Gupta R, 2012, NAT PROD RES, V26, P1125, DOI 10.1080/14786419.2011.560845
   Han SY, 2021, ACTA DIABETOL, V58, P495, DOI 10.1007/s00592-020-01652-z
   Hashmi WJ, 2020, BRAZ J PHARM SCI, V56, DOI 10.1590/s2175-97902019000318406
   Hashmi WJ, 2018, DARU, V26, P179, DOI 10.1007/s40199-018-0223-3
   Hata K, 2008, PHYTOCHEM LETT, V1, P191, DOI 10.1016/j.phytol.2008.09.007
   Hemmati M, 2015, PAK J PHARM SCI, V28, P2095
   Hemmati M, 2015, EXCLI J, V14, P908, DOI 10.17179/excli2015-232
   Hernández F, 2016, J SCI FOOD AGR, V96, P2682, DOI 10.1002/jsfa.7386
   Hoseinifar SH, 2019, FISH SHELLFISH IMMUN, V94, P705, DOI 10.1016/j.fsi.2019.09.016
   Hossain MA, 2019, J KING SAUD UNIV SCI, V31, P1352, DOI 10.1016/j.jksus.2018.12.003
   Huang XJ, 2018, INT J BIOL SCI, V14, P1483, DOI 10.7150/ijbs.27173
   Humphrey JD, 2021, AM J HYPERTENS, V34, P432, DOI 10.1093/ajh/hpaa195
   Jalali J, 2022, J ETHNOPHARMACOL, V299, DOI 10.1016/j.jep.2022.115672
   Jayavabhushana V., 2019, Drug Invent Today, V12, P866
   Jeong O, 2019, NUTR METAB, V16, DOI 10.1186/s12986-019-0364-5
   Badimón JJ, 2010, REV ESP CARDIOL, V63, P323, DOI 10.1016/S0300-8932(10)70091-9
   Kamkar-Del Yasamin, 2020, Cardiovascular & Hematological Disorders - Drug Targets, V20, P108, DOI 10.2174/1871529X19666191119141400
   Kandimalla R, 2017, FRONT CELL NEUROSCI, V11, DOI 10.3389/fncel.2017.00073
   Kawabata K, 2017, J NUTR SCI VITAMINOL, V63, P193, DOI 10.3177/jnsv.63.193
   Khanna D, 2022, CUREUS J MED SCIENCE, V14, DOI 10.7759/cureus.22711
   Khataylou YJ, 2021, BETULINIC ACID REDUC
   Kim HK., 2019, CURR DEV NUTR, V3, pnzz041.P21, DOI [10.1093/cdn/nzz041.P21-043-19, DOI 10.1093/CDN/NZZ041.P21-043-19]
   Kim HK, 2021, J AGR FOOD CHEM, V69, P12465, DOI 10.1021/acs.jafc.1c04797
   Kim HK, 2017, FASEB J, V31
   Kim J, 2012, PHYTOTHER RES, V26, P1103, DOI 10.1002/ptr.3672
   Kim KD, 2019, NUTR METAB CARDIOVAS, V29, P409, DOI 10.1016/j.numecd.2018.12.001
   Kim SJ, 2014, J AGR FOOD CHEM, V62, P434, DOI 10.1021/jf4030739
   Klop B, 2013, NUTRIENTS, V5, P1218, DOI 10.3390/nu5041218
   Kojta I, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051305
   Koliaki C, 2020, CURR OBES REP, V9, P255, DOI 10.1007/s13679-020-00396-9
   Konno T, 2020, MOL MED REP, V21, P1552, DOI 10.3892/mmr.2020.10946
   Kottireddy S., 2019, Drug Invent Today, V11, P2258
   Kubota H, 2009, AM J CHINESE MED, V37, P597, DOI 10.1142/S0192415X09007089
   Kumar AV., 2008, NAT PROD, V4, P132
   Kwon M, 2023, HEALTHCARE-BASEL, V11, DOI 10.3390/healthcare11142015
   Laakso M., 2009, ENDOCRINOL NUTR, V56, P43, DOI [10.1016/S1575-0922(09)73517-X, DOI 10.1016/S1575-0922(09)73517-X]
   Lee D, 2021, BIOMOLECULES, V11, DOI 10.3390/biom11111614
   Lee HA, 2024, ARCH PHYSIOL BIOCHEM, V130, P452, DOI 10.1080/13813455.2022.2120503
   Lee HA, 2021, TOXICOL RES-UK, V10, P495, DOI 10.1093/toxres/tfab019
   Li H, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11193001
   Li J, 2021, ANN TRANSL MED, V9, DOI 10.21037/atm-21-4561
   Liu HY, 2022, FERMENTATION-BASEL, V8, DOI 10.3390/fermentation8020054
   Loewith R, 2011, GENETICS, V189, P1177, DOI 10.1534/genetics.111.133363
   Longo M, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20092358
   Loperena R, 2017, MED CLIN N AM, V101, P169, DOI 10.1016/j.mcna.2016.08.004
   Mancini GJ., 2018, DIABETES, V42, pS178
   Manna P, 2015, METAB SYNDR RELAT D, V13, P423, DOI 10.1089/met.2015.0095
   Masenga SK, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24097898
   Mesaik Ahmed M, 2018, Open Access Maced J Med Sci, V6, P757, DOI 10.3889/oamjms.2018.168
   Miri M, 2018, 1 NAT C INT FAIR MED, P1
   Mohebbati R, 2019, J REP PHARM SCI, V8, P224, DOI 10.4103/jrptps.JRPTPS_61_18
   Mohebbati R, 2020, MALAYS J MED SCI, V27, P43, DOI 10.21315/mjms2020.27.3.5
   Mohebbati R, 2017, ANC SCI LIFE, V37, P68, DOI 10.4103/asl.ASL_122_17
   Mohebbati R, 2018, AVICENNA J PHYTOMEDI, V8, P143
   Mohsen GA, 2019, J INFECT PUBLIC HEAL, V12, P726, DOI 10.1016/j.jiph.2019.05.011
   Muri J, 2020, CELL REP, V30, P4399, DOI 10.1016/j.celrep.2020.03.019
   Najafi N, 2022, PHYTOTHER RES, V36, P2300, DOI 10.1002/ptr.7406
   Naraki K, 2023, HELIYON, V9, DOI 10.1016/j.heliyon.2023.e21844
   Niki E, 2008, BIOFACTORS, V34, P171, DOI 10.1002/biof.5520340208
   Nolan CJ, 2019, DIABETES VASC DIS RE, V16, P118, DOI 10.1177/1479164119827611
   Oskouei Z, 2023, IRAN J BASIC MED SCI, V26, P738, DOI 10.22038/IJBMS.2023.65997.14512
   Padmapriya N., 2019, Drug Invent Today, V12, P1897
   Periasamy Srinivasan, 2015, Asian Pac J Cancer Prev, V16, P7561
   Pu YF, 2019, CYTA-J FOOD, V17, P158, DOI 10.1080/19476337.2019.1566277
   Qian LB, 2012, INDIAN J PHARMACOL, V44, P588, DOI 10.4103/0253-7613.100382
   Qiu YH, 2023, INT J BIOL MACROMOL, V253, DOI 10.1016/j.ijbiomac.2023.127042
   Quan HY, 2013, BIOCHEM PHARMACOL, V85, P1330, DOI 10.1016/j.bcp.2013.02.007
   Rader DJ, 2009, J LIPID RES, V50, pS189, DOI 10.1194/jlr.R800088-JLR200
   Ramu R, 2016, PLOS ONE, V11, DOI [10.1371/journal.pone.0151135, 10.1371/journal.pone.0160048]
   Richter EA, 2009, BIOCHEM J, V418, P261, DOI 10.1042/BJ20082055
   Sabzghabaee Ali Mohammad, 2013, Med Arch, V67, P156
   Sakna ST, 2023, PHYTOCHEM REV, V22, P1611, DOI 10.1007/s11101-022-09835-y
   Samuel VT, 2016, J CLIN INVEST, V126, P12, DOI 10.1172/JCI77812
   Savova MS, 2022, BIOMED PHARMACOTHER, V156, DOI 10.1016/j.biopha.2022.113862
   Savova MS, 2021, BIOMED PHARMACOTHER, V141, DOI 10.1016/j.biopha.2021.111934
   Saxton RA, 2017, CELL, V168, P960, DOI [10.1016/j.cell.2017.02.004, 10.1016/j.cell.2017.03.035]
   Senamontree S, 2021, PEERJ, V9, DOI 10.7717/peerj.12321
   Shahrajabian Mohamad Hesam, 2020, Annales Universitatis Paedagogicae Cracoviensis Studia Naturae, P194, DOI 10.24917/25438832.5.13
   Shreenithi S., 2019, DRUG INVENT TODAY, V11, P1113
   Sobhani Z, 2020, MED CHEM, V16, P1069, DOI 10.2174/1573406415666191031143553
   Song TJ, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0249109
   Soysal P, 2020, ADV EXP MED BIOL, V1216, P55, DOI 10.1007/978-3-030-33330-0_7
   Steinkamp-Fenske K, 2007, J PHARMACOL EXP THER, V322, P836, DOI 10.1124/jpet.107.123356
   Sudhahar V, 2006, LIFE SCI, V78, P1329, DOI 10.1016/j.lfs.2005.07.011
   Tangvarasittichai S, 2015, WORLD J DIABETES, V6, P456, DOI 10.4239/wjd.v6.i3.456
   Thomas DD, 2019, J ENDOCR SOC, V3, P1727, DOI 10.1210/js.2019-00065
   Vasanth K, 2022, J FOOD BIOCHEM, V46, DOI 10.1111/jfbc.14170
   Vona R, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8267234
   Wen X, 2022, SIGNAL TRANSDUCT TAR, V7, DOI 10.1038/s41392-022-01149-x
   Xiao Z, 2020, LIFE SCI, V256, DOI 10.1016/j.lfs.2020.117997
   Yahyazadeh R, 2021, IRAN J BASIC MED SCI, V24, P1462, DOI [10.22038/IJBMS.2021.54417.12228, 10.22038/ijbms.2021.54417.12228]
   Yamaguchi Y, 2006, LIFE SCI, V79, P2474, DOI 10.1016/j.lfs.2006.08.007
   Yaribeygi H, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/8609213
   Yarmohammadi F, 2021, IRAN J BASIC MED SCI, V24, P420, DOI 10.22038/ijbms.2021.50276.11452
   Yazdanpanah Z, 2017, PHYTOTHER RES, V31, P755, DOI 10.1002/ptr.5796
   Yi JN, 2014, J VET SCI, V15, P141, DOI 10.4142/jvs.2014.15.1.141
   Yildirim V, 2023, JCI INSIGHT, V8, DOI 10.1172/jci.insight.166905
   Yoon JJ, 2017, EUR J PHARMACOL, V796, P224, DOI 10.1016/j.ejphar.2016.11.044
   Yoon JJ, 2010, J CELL BIOCHEM, V111, P1501, DOI 10.1002/jcb.22880
   Zainub A., 2019, J ISLAMIC INT MED CO, V14, P121
   Zhang J, 2021, ARAB J CHEM, V14, DOI 10.1016/j.arabjc.2020.102934
   Zhao Y, 2014, FOOD FUNCT, V5, P1771, DOI [10.1039/c3fo60707k, 10.1039/C3FO60707K]
NR 149
TC 5
Z9 5
U1 6
U2 11
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2161-3311
J9 CURR NUTR REP
JI Curr. Nutr. Rep.
PD DEC
PY 2024
VL 13
IS 4
BP 845
EP 866
DI 10.1007/s13668-024-00581-5
EA OCT 2024
PG 22
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA J2S9D
UT WOS:001326644200001
PM 39354208
DA 2025-06-11
ER

PT J
AU dos Santos, LL
   Silva, ATB
   da Cruz, MADP
   da Rosa, SE
   Fortes, MDR
   Nunes, RDM
   de Castro, JBP
   Linhares, DG
   dos Santos, AOB
   Cordeiro, LD
   Borba-Pinheiro, CJ
   Vale, RGD
AF dos Santos, Luciano Lima
   Silva, Aline Tito Barbosa
   da Cruz, Marcos Alexandre de Souza Pecanha
   da Rosa, Samir Ezequiel
   Fortes, Marcos de Sa Rego
   Nunes, Rodolfo de Alkmim Moreira
   de Castro, Juliana Brandao Pinto
   Linhares, Diego Gama
   dos Santos, Andressa Oliveira Barros
   Cordeiro, Lilliany de Souza
   Borba-Pinheiro, Claudio Joaquim
   Vale, Rodrigo Gomes de Souza
TI Effects of Long and Sprint High-Intensity Interval Training on Body Mass
   Composition, Aerobic Capacity, and Biochemical Markers of Metabolic
   Syndrome and Liver Damage in Physical Activity Practitioners Adults
SO MLTJ-MUSCLES LIGAMENTS AND TENDONS JOURNAL
LA English
DT Article
DE Metabolic syndrome; metabolic associated fatty liver disease;
   high-intensity long interval training; sprint interval training;
   training impulse
ID VISCERAL FAT; EXERCISE; PERFORMANCE; PROGRAM
AB Background. Highlights High -Intensity Long Interval Training (HILIT) and Sprint Interval Training (SIT) to morpho functional improvement and reduce effects of Metabolic Associated Fatty Liver Disease (MAFLD) and the Metabolic Syndrome (MS). Objective. This study aims to verify the effects of HILIT and SIT on physiological and pathological markers of MS and liver health in adults submitted to 12 weeks of training. Methods. A randomized clinical trial was carried out with a design for two groups, HILIT and SIT Groups. The sample consisted of 38 physical activity practitioners male adults aged between 30 and 55 years (42.75 +/- 8.26). Body composition assessments, cardiac stress tests, measurements of blood pressure (BP), and blood samples were analyzed: triglycerides (TRIG), high -density lipoprotein (HDL-C) and glucose (GLU) and liver damage: Albumin (ALB), Bilirubin (BIL), Aspartate Aminotransferase (AST), Alamine Aminotransferase (ALT), Gamma Glutamyl Transferase (GGT). Results. For HILIT there was a significant intragroup improvement in the parameters of fat mass, lean mass, body mass index (BMI), visceral adipose fat (VAT), GLU, ALB, Direct Bilirubin (DB), distance run, and oxygen consumption (VO2). For SIT there was a significant intragroup improvement in the parameters of VAT, GLU, ALB, DB, GGT, and distance run. There was a significant difference in the intergroup comparison only for BP in favor of the SIT group. Conclusions. We conclude that 12 weeks of HILIT and SIT interval training were able to produce positive effects on body composition variables, aerobic capacity, Metabolic Syndrome, and Liver Health in physical activity practitioners adult men, with better results for HILIT in this population.
C1 [dos Santos, Luciano Lima; Nunes, Rodolfo de Alkmim Moreira; de Castro, Juliana Brandao Pinto; Linhares, Diego Gama; dos Santos, Andressa Oliveira Barros; Cordeiro, Lilliany de Souza; Vale, Rodrigo Gomes de Souza] Univ Estado Rio De Janeiro, Postgrad Program Exercise & Sport Sci, Rio De Janeiro, Brazil.
   [dos Santos, Luciano Lima; Nunes, Rodolfo de Alkmim Moreira; de Castro, Juliana Brandao Pinto; Linhares, Diego Gama; dos Santos, Andressa Oliveira Barros; Cordeiro, Lilliany de Souza; Vale, Rodrigo Gomes de Souza] Univ Estado Rio De Janeiro, Inst Phys Educ & Sports, Lab Exercise & Sport, Rio De Janeiro, Brazil.
   [Borba-Pinheiro, Claudio Joaquim] Para State Univ, Fed Inst Para, Belem, Para, Brazil.
   [Silva, Aline Tito Barbosa; da Cruz, Marcos Alexandre de Souza Pecanha; da Rosa, Samir Ezequiel; Fortes, Marcos de Sa Rego] Army Phys Training Res Inst, Rio De Janeiro, Brazil.
C3 Universidade do Estado do Rio de Janeiro; Universidade do Estado do Rio
   de Janeiro; Instituto Federal do Para; Universidade do Estado do Para
   (UEPA)
RP dos Santos, LL (corresponding author), Univ Estado Rio De Janeiro, R Sao Francisco Xavier 524, BR-20550013 Maracana, RJ, Brazil.
EM luciano.pentatlo@hotmail.com
RI DA ROSA, SAMIR/ABB-9329-2021; Linhares, Diego/LYO-9815-2024; Vale,
   Rodrigo/F-7429-2012; Castro, Juliana/E-5338-2016
OI Gama Linhares, Diego/0000-0002-2901-3273
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Amaro-Gahete FJ, 2019, SCAND J MED SCI SPOR, V29, P968, DOI 10.1111/sms.13414
   Andreato LV, 2019, OBES REV, V20, P142, DOI 10.1111/obr.12766
   Oliveira LVA, 2020, CIENC SAUDE COLETIVA, V25, P4269, DOI 10.1590/1413-812320202511.31202020
   Balady GJ, 2010, CIRCULATION, V122, P191, DOI 10.1161/CIR.0b013e3181e52e69
   Beck TW, 2013, J STRENGTH COND RES, V27, P2323, DOI 10.1519/JSC.0b013e318278eea0
   Bellicha A, 2021, OBES REV, V22, DOI 10.1111/obr.13256
   Ben Abderrahman A, 2013, EUR J APPL PHYSIOL, V113, P1373, DOI 10.1007/s00421-012-2556-9
   Bentley DJ, 2007, SPORTS MED, V37, P575, DOI 10.2165/00007256-200737070-00002
   Bishop D, 2011, SPORTS MED, V41, P741, DOI 10.2165/11590560-000000000-00000
   Blüher M, 2019, NAT REV ENDOCRINOL, V15, P288, DOI 10.1038/s41574-019-0176-8
   Buchheit M, 2013, SPORTS MED, V43, P927, DOI 10.1007/s40279-013-0066-5
   Buchheit M, 2013, SPORTS MED, V43, P313, DOI 10.1007/s40279-013-0029-x
   Carson C, 2018, PHYSIOL GENOMICS, V50, P947, DOI 10.1152/physiolgenomics.00072.2018
   Cress M, 2015, ACSMS HEALTH FIT J, V19, P3, DOI 10.1249/FIT.0000000000000157
   de Oliveira-Nunes SG, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph182413120
   dos Santos LL, 2023, RETOS-NUEV TEND EDUC, P762
   Eguchi Y, 2020, HEPATOL RES, V50, P645, DOI 10.1111/hepr.13502
   Eslam M, 2020, J HEPATOL, V73, P202, DOI 10.1016/j.jhep.2020.03.039
   Faul F, 2007, BEHAV RES METHODS, V39, P175, DOI 10.3758/BF03193146
   Fernandes Franca E, 2020, Int Am J Med Health, V3, P3, DOI [10.31005/iajmh.v3i0.144, DOI 10.31005/IAJMH.V3I0.144]
   Field A, 2009, Aletheia, V2009th, P202
   Field A, 2011, Aletheia, V2009th, P202
   Foster C, 2017, INT J SPORT PHYSIOL, V12, P2, DOI [10.1123/IJSPP.2016-0388, 10.1123/ijspp.2016-0388]
   Fradkin AJ, 2010, J STRENGTH COND RES, V24, P140, DOI 10.1519/JSC.0b013e3181c643a0
   Germano MD, 2022, J STRENGTH COND RES, V36, P121, DOI 10.1519/JSC.0000000000003423
   Gripp F, 2013, ACSMs Health Fit J, V8, P87, DOI [10.1371/journal.pone.0056415, DOI 10.1371/JOURNAL.PONE.0056415]
   Gripp F, 2021, EUR J APPL PHYSIOL, V121, P159, DOI 10.1007/s00421-020-04502-6
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Gupta P, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-49162-5
   Harman EA, 2008, J STRENGTH COND RES, V22, P524, DOI 10.1519/JSC.0b013e31816347b6
   Hayes PR, 2009, EUR J APPL PHYSIOL, V106, P839, DOI 10.1007/s00421-009-1084-8
   Irving BA, 2008, MED SCI SPORT EXER, V40, P1863, DOI 10.1249/MSS.0b013e3181801d40
   Khalafi M, 2021, PHYSIOL BEHAV, V236, DOI 10.1016/j.physbeh.2021.113416
   Kiani Aysha Karim, 2022, J Prev Med Hyg, V63, pE267, DOI 10.15167/2421-4248/jpmh2022.63.2S3.2769
   Kumari R, 2019, DIABETES METAB SYND, V13, P2409, DOI 10.1016/j.dsx.2019.06.005
   Le Jemtel TH, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0880-0
   Liang MY, 2021, REV CARDIOVASC MED, V22, P1523, DOI 10.31083/j.rcm2204156
   Liu JY, 2021, INT J PUBLIC HEALTH, V66, DOI 10.3389/ijph.2021.1604371
   Maillard F, 2018, SPORTS MED, V48, P269, DOI 10.1007/s40279-017-0807-y
   Mayorga-Vega D, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0151671
   Mello DB, 2021, Revista Brasileira de Prescricao e Fisi- ologia do Exercicio, V20, P490, DOI [10.33233/rbfex.v20i4.4752, DOI 10.33233/RBFEX.V20I4.4752]
   Murias JM, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00143
   Parmar A, 2021, J SPORT SCI, V39, P1410, DOI 10.1080/02640414.2021.1876313
   Probst Y, 2016, CRIT REV FOOD SCI, V56, P2069, DOI 10.1080/10408398.2013.816653
   Ramos D, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0131766
   Fortes MDR, 2019, ARCH ENDOCRIN METAB, V63, P345, DOI 10.20945/2359-3997000000115
   Rosenblat MA, 2020, SPORTS MED, V50, P1145, DOI 10.1007/s40279-020-01264-1
   Schoch Lisa, 2007, Nursing, V37, P22
   Slomko J, 2021, J CLIN MED, V10, DOI 10.3390/jcm10081659
   Taylor J, 2017, CONT CLIN TRIAL COMM, V8, P181, DOI 10.1016/j.conctc.2017.10.002
   Taylor JL, 2020, OBESITY, V28, P1245, DOI 10.1002/oby.22833
   Triola MF, 1999, Introducao a Estatistica, V7a, P299
   Valente R, 2020, Pentagono A
   Vecchio Fabricio Boscolo Del, 2022, Rev. bras. cineantropom. desempenho hum., V24, pe86265
   Wewege M, 2017, OBES REV, V18, P635, DOI 10.1111/obr.12532
   Woreta TA, 2014, MED CLIN N AM, V98, P1, DOI 10.1016/j.mcna.2013.09.005
   Zhou BJ, 2021, EUR REV MED PHARMACO, V25, P7687, DOI [10.37766/inplasy2021.8.0062, 10.26355/eurrev_202112_27615]
NR 58
TC 0
Z9 0
U1 1
U2 1
PU EDRA SPA
PI MILANO
PA VIA G SPADOLINI, 7, MILANO, 20141, ITALY
SN 2240-4554
J9 MLTJ-MUSCLE LIGAMENT
JI MLTJ-Muscles Ligaments Tendons J.
PD APR-JUN
PY 2024
VL 14
IS 2
BP 256
EP 268
DI 10.32098/mltj.02.2024.04
PG 13
WC Orthopedics
WE Emerging Sources Citation Index (ESCI)
SC Orthopedics
GA WK4W5
UT WOS:001254760300005
OA Bronze
DA 2025-06-11
ER

PT J
AU Taghizadeh, N
   Sharifan, P
   Toosi, MSE
   Doust, FNS
   Darroudi, S
   Afshari, A
   Rezaie, M
   Safarian, M
   Vatanparast, H
   Eslami, S
   Ghazizadeh, H
   Khorasanchi, Z
   Bagherniya, M
   Ferns, G
   Darban, RA
   Ghayour-Mobarhan, M
AF Taghizadeh, Niloofar
   Sharifan, Payam
   Toosi, Mansoureh Sadat Ekhteraee
   Doust, Fatemeh Najar Sedgh
   Darroudi, Susan
   Afshari, Asma
   Rezaie, Mitra
   Safarian, Mohamad
   Vatanparast, Hassan
   Eslami, Saeed
   Ghazizadeh, Hamideh
   Khorasanchi, Zahra
   Bagherniya, Mohammad
   Ferns, Gordon
   Darban, Reza Assaran
   Ghayour-Mobarhan, Majid
TI The effects of consuming a low-fat yogurt fortified with nano
   encapsulated vitamin D on serum pro-oxidant-antioxidant balance (PAB) in
   adults with metabolic syndrome; a randomized control trial
SO DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
LA English
DT Article
DE Vitamin D; Fortification; Prooxidant-antioxidant balance; Metabolic
   syndrome; Nano encapsulation
ID D DEFICIENCY; OXIDATIVE STRESS; DAIRY-PRODUCTS; PROBIOTIC YOGURT;
   DISEASE-ACTIVITY; CROHNS-DISEASE; ASSOCIATION; CALCIUM; INFLAMMATION;
   ANTICANCER
AB Background and aim: The current study aimed to assess the effect of fortified yogurt with nano-encapsulated vitamin D on serum pro-oxidant anti-oxidant balance (PAB) in adults with or without metabolic syndrome.
   Methods: In a quadruple blind clinical trial study, 139 adults with an age range of 30-50 years were randomly selected to receive either 1500 IU nano-encapsulated vitamin D fortified yogurt or placebo for ten weeks. Before and after the intervention period, blood sample was taken to determine the serum levels of vitamin D, pro-oxidant-antioxidant balance (PAB), and high-sensitivity C-reactive protein (hs-CRP). The laboratory tests were checked at baseline and at the end of the treatment.
   Results: Serum vitamin D increased significantly, from 14.47 +/- 6.07 ng/mL to 21.39 +/- 6.54 ng/mL (P < 0.001) after ten weeks in the intervention group. Serum hs-CRP and PAB were significantly lower following consumption period in intervention group [1.95(0.4-8.15) g/dL vs. 1.35(0.25-3.62) g/dL; P = 0.013] and (135.19 +/- 42.4 HK vs. 115.39 +/- 44.69) HK; P = 0.018] respectively. There were no significant differences between the intervention and control groups regarding weight and BMI at the end of the intervention period (p > 0.05).
   Conclusion: Low-fat yogurt fortified with nano-encapsulated vitamin D was found to reduce serum PAB levels in adults with metabolic syndrome. (C) 2021 Diabetes India. Published by Elsevier Ltd. All rights reserved.
C1 [Taghizadeh, Niloofar; Toosi, Mansoureh Sadat Ekhteraee; Doust, Fatemeh Najar Sedgh; Darban, Reza Assaran] Islamic Azad Univ, Fac Sci, Dept Biol, Mashhad Branch, Mashhad, Razavi Khorasan, Iran.
   [Sharifan, Payam; Afshari, Asma; Rezaie, Mitra; Safarian, Mohamad; Khorasanchi, Zahra; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Sch Med, Dept Nutr, Mashhad, Razavi Khorasan, Iran.
   [Darroudi, Susan; Ghazizadeh, Hamideh; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Int UNESCO Ctr Hlth Related Basic Sci & Human Nut, Mashhad, Razavi Khorasan, Iran.
   [Sharifan, Payam; Ghazizadeh, Hamideh] Mashhad Univ Med Sci, Sch Med, Student Res Comm, Mashhad, Razavi Khorasan, Iran.
   [Vatanparast, Hassan] Univ Saskatchewan, Coll Pharm & Nutr, Saskatoon, SK, Canada.
   [Eslami, Saeed] Mashhad Univ Med Sci, Pharmaceut Res Ctr, Sch Pharm, Mashhad, Razavi Khorasan, Iran.
   [Bagherniya, Mohammad] Isfahan Univ Med Sci, Food Secur Res Ctr, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
   [Ferns, Gordon] Brighton & Sussex Med Sch, Div Med Educ, Brighton, E Sussex, England.
C3 Islamic Azad University; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences;
   University of Saskatchewan; Mashhad University of Medical Sciences;
   Isfahan University of Medical Sciences; University of Brighton;
   University of Sussex
RP Darban, RA (corresponding author), Islamic Azad Univ, Fac Sci, Dept Biol, Mashhad Branch, Mashhad, Razavi Khorasan, Iran.; Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad 9919991766, Razavi Khorasan, Iran.
EM mrassaran78@gmail.com; ghayourm@mums.ac.ir
RI Ghayour-Mobarhan, Majid/AAY-5963-2020; Ghazizadeh,
   Hamideh/ABE-8941-2020; khorasanchi, zahra/ABD-4405-2021; Afshari,
   Asma/AAW-9511-2020; Assaran Draban, Reza/S-3572-2017
OI khorasanchi, zahra/0000-0001-9579-9465
FU Elite Researcher Grant Committee from the National Institutes for
   Medical Research Development (NIMAD), Tehran, Iran [957705]; Mashhad
   University of Medical Sciences (MUMS), Mashhad, Iran
FX Research reported in this publication was supported by Elite Researcher
   Grant Committee under award number [957705] from the National Institutes
   for Medical Research Development (NIMAD), Tehran, Iran and Mashhad
   University of Medical Sciences (MUMS), Mashhad, Iran.
CR Akbari M, 2018, INFLAMMOPHARMACOLOGY, V26, P899, DOI 10.1007/s10787-018-0508-7
   Alamdari DH, 2008, CLIN BIOCHEM, V41, P375, DOI 10.1016/j.clinbiochem.2007.12.008
   Alamdari DH, 2007, CLIN BIOCHEM, V40, P248, DOI 10.1016/j.clinbiochem.2006.10.017
   Alamdari DH, 2009, IRAN J BASIC MED SCI, V12, P93
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Batista ALD, 2015, FOOD RES INT, V77, P627, DOI 10.1016/j.foodres.2015.08.017
   Chen SJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0045693
   Darroudi S, 2019, BIOFACTORS, V45, P35, DOI 10.1002/biof.1459
   Farhangi MA, 2017, BMC CARDIOVASC DISOR, V17, DOI 10.1186/s12872-017-0597-z
   Fazilah NF, 2018, J FUNCT FOODS, V48, P387, DOI 10.1016/j.jff.2018.07.039
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Ferreira PP, 2020, CLIMACTERIC, V23, P24, DOI [10.1007/s10111-019-00540-z, 10.1080/13697137.2019.1611761]
   Filgueiras MS, 2020, CRIT REV FOOD SCI, V60, P660, DOI 10.1080/10408398.2018.1546671
   Fu JL, 2019, CLIN NUTR, V38, P2161, DOI 10.1016/j.clnu.2018.08.039
   Gasparri C, 2019, J DAIRY SCI, V102, P8587, DOI 10.3168/jds.2018-16046
   Ghayour-Mobarhan M, 2009, INDIAN J PEDIATR, V76, P1145, DOI 10.1007/s12098-009-0231-x
   Ghazizadeh H, 2020, ARCH MED RES, V51, P261, DOI 10.1016/j.arcmed.2020.02.006
   Ghazizadeh H, 2020, MOL BIOL REP, V47, P867, DOI 10.1007/s11033-019-05081-2
   Habdous M, 2003, CLIN CHEM LAB MED, V41, P209, DOI 10.1515/CCLM.2003.034
   Halliwell B., 2015, Free Radicals in Biology and Medicine
   Ham M, 2014, INFLAMM BOWEL DIS, V20, P856, DOI 10.1097/MIB.0000000000000016
   Heydari S, 2018, INT J DAIRY TECHNOL, V71, P175, DOI 10.1111/1471-0307.12491
   Holick MF, 2011, J CLIN ENDOCR METAB, V96, P1911, DOI [10.1210/jc.2011-0385, 10.1210/jc.2011-1193]
   Jafari SM, 2019, FOOD BIOPROCESS TECH, V12, P1220, DOI 10.1007/s11947-019-02289-9
   Jafari T, 2016, CLIN NUTR, V35, P67, DOI 10.1016/j.clnu.2015.02.014
   Jaksic M, 2019, J PEDIATR ENDOCR MET, V32, P951, DOI 10.1515/jpem-2019-0086
   Jun JC, 2019, INTEST RES, V17, P210, DOI 10.5217/ir.2018.00081
   Kelly P, 2011, INT J VITAM NUTR RES, V81, P205, DOI 10.1024/0300-9831/a000066
   Korkmaz GG, 2013, METABOLISM, V62, P828, DOI 10.1016/j.metabol.2013.01.002
   Ma YY, 2016, VITAM HORM, V100, P395, DOI 10.1016/bs.vh.2015.11.003
   Melo SRdS., 2020, RES SOC DEV, V9
   Mirhafez SR, 2015, BRIT J NUTR, V113, P1911, DOI 10.1017/S0007114515001038
   Moosavian SP, 2020, NUTR METAB CARDIOVAS, V30, P872, DOI 10.1016/j.numecd.2020.01.011
   Mostafai R, 2019, J FUNCT FOODS, V52, P116, DOI 10.1016/j.jff.2018.10.040
   Mostafai R, 2018, J FUNCT FOODS, V42, P137, DOI 10.1016/j.jff.2018.01.001
   Pereira MA, 2002, JAMA-J AM MED ASSOC, V287, P2081, DOI 10.1001/jama.287.16.2081
   Raftery T, 2015, DIGEST DIS SCI, V60, P2427, DOI 10.1007/s10620-015-3620-1
   Saedisomeolia A, 2013, Indian J Med Sci, V67, P29
   Sinbad OO., 2019, Journal of food science and nutrition research, V2, P214, DOI DOI 10.26502/JFSNR.2642-11000021
   Tabrizi R, 2018, IRAN J MED SCI, V43, P125
   Tagliaferri S, 2019, NUTR RES REV, V32, P99, DOI 10.1017/S0954422418000197
   Tangpricha V, 2002, AM J MED, V112, P659, DOI 10.1016/S0002-9343(02)01091-4
   Timar A, 2019, ADV MED SCI-POLAND, V64, P174, DOI 10.1016/j.advms.2018.10.004
   Ulitsky A, 2011, JPEN-PARENTER ENTER, V35, P308, DOI 10.1177/0148607110381267
   Vanoirbeek E, 2011, BEST PRACT RES CL EN, V25, P593, DOI 10.1016/j.beem.2011.05.001
   Wang EW, 2017, BRIT J NUTR, V118, P11, DOI 10.1017/S000711451700188X
   Wilmanski T, 2017, CANCER LETT, V411, P171, DOI 10.1016/j.canlet.2017.09.045
   Wimalawansa SJ, 2019, BIOLOGY-BASEL, V8, DOI 10.3390/biology8020030
   Yang SS, 2021, FOOD BIOSCI, V42, DOI 10.1016/j.fbio.2021.101104
   Zahedirad M, 2019, INT DAIRY J, V94, P53, DOI 10.1016/j.idairyj.2019.01.013
   Zemel MB, 2004, AM J CLIN NUTR, V79, P907
   Zemel MB, 2004, OBES RES, V12, P582, DOI 10.1038/oby.2004.67
   Zemel MB, 2008, J NUTR, V138, P1047, DOI 10.1093/jn/138.6.1047
NR 53
TC 21
Z9 24
U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-4021
EI 1878-0334
J9 DIABETES METAB SYND
JI Diabetes Metab. Syndr.-Clin. Res. Rev.
PD NOV-DEC
PY 2021
VL 15
IS 6
AR 102332
DI 10.1016/j.dsx.2021.102332
EA NOV 2021
PG 7
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA XK6BU
UT WOS:000727549300029
PM 34781136
DA 2025-06-11
ER

PT J
AU Kim, NH
   Han, KH
   Choi, J
   Lee, J
   Kim, SG
AF Kim, Nam Hoon
   Han, Ki Hoon
   Choi, Jimi
   Lee, Juneyoung
   Kim, Sin Gon
TI Use of fenofibrate on cardiovascular outcomes in statin users with
   metabolic syndrome: propensity matched cohort study
SO BMJ-BRITISH MEDICAL JOURNAL
LA English
DT Article
ID RESIDUAL RISK; DISEASE; THERAPY; EVENTS; CHOLESTEROL; METAANALYSIS;
   REDUCTION; MORTALITY; SURVIVAL; STRESS
AB OBJECTIVE
   To investigate whether fenofibrate as add-on to statin treatment reduce persistent cardiovascular risk in adults with metabolic syndrome in a real world setting.
   DESIGN
   Propensity matched cohort study.
   SETTING
   Population based cohort in Korea.
   PARTICIPANTS
   29 771 adults with metabolic syndrome (>= 40 years) receiving statin treatment. 2156 participants receiving combined treatment (statin plus fenofibrate) were weighted based on propensity score in a 1:5 ratio with 8549 participants using statin only treatment.
   MAIN OUTCOME MEASURE
   Primary outcome was composite cardiovascular events including incident coronary heart disease, ischaemic stroke, and death from cardiovascular causes.
   RESULTS
   The incidence rate per 1000 person years of composite cardiovascular events was 17.7 (95% confidence interval 14.4 to 21.8) in the combined treatment group and 22.0 (20.1 to 24.1) in the statin group. The risk of composite cardiovascular events was significantly reduced in the combined treatment group compared with statin group (adjusted hazard ratio 0.74, 95% confidence interval 0.58 to 0.93; P=0.01). The significance was maintained in the on-treatment analysis (hazard ratio 0.63, 95% confidence interval 0.44 to 0.92; P=0.02). The risk of incident coronary heart disease, ischaemic stroke, and cardiovascular death was lower in the combined treatment group than statin group but was not significant. Participant characteristics did not appear to be associated with the low risk of composite cardiovascular events with combined treatment.
   CONCLUSION
   In this propensity weighted cohort study of adults with metabolic syndrome, the risk of major cardiovascular events was significantly lower with fenofibrate as add-on to statin treatment than with statin treatment alone.
C1 [Kim, Nam Hoon; Kim, Sin Gon] Korea Univ, Coll Med, Anam Hosp, Div Endocrinol & Metab,Dept Internal Med, 126-1,Anam Dong 5 Ga, Seoul 02841, South Korea.
   [Han, Ki Hoon] Ulsan Univ, Dept Internal Med, Seoul, South Korea.
   [Choi, Jimi; Lee, Juneyoung] Korea Univ, Coll Med, Dept Biostat, Seoul, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine); University of
   Ulsan; Korea University; Korea University Medicine (KU Medicine)
RP Kim, SG (corresponding author), Korea Univ, Coll Med, Anam Hosp, Div Endocrinol & Metab,Dept Internal Med, 126-1,Anam Dong 5 Ga, Seoul 02841, South Korea.
EM k50367@korea.ac.kr
RI Choi, So/AAV-1947-2020; Lee, Jun Young/CAI-2335-2022; Kim, Nam
   Hoon/HNS-5794-2023; Kim, Sin Gon/KQU-7757-2024
OI Lee, Juneyoung/0000-0001-8073-9304; Kim, Sin Gon/0000-0002-7430-3675;
   Kim, Nam Hoon/0000-0002-9926-1344
FU Abbott Laboratories Korea
FX This study was supported by the Abbott Laboratories Korea. The funders
   had no role in the design and conduct of the study; analysis,
   preparation, review, and approval of the manuscript.
CR Austin PC, 2014, STAT MED, V33, P1242, DOI 10.1002/sim.5984
   Authors/Task Force Members:, 2016, Atherosclerosis, V253, P281, DOI 10.1016/j.atherosclerosis.2016.08.018
   Bruckert E, 2011, J CARDIOVASC PHARM, V57, P267, DOI 10.1097/FJC.0b013e318202709f
   Cannon CP, 2015, NEW ENGL J MED, V372, P2387, DOI 10.1056/NEJMoa1410489
   Chen Ai-Hua, 2013, Rev Diabet Stud, V10, P101, DOI 10.1900/RDS.2013.10.101
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Fruchart JC, 2009, ATHEROSCLEROSIS, V205, P1, DOI 10.1016/j.atherosclerosis.2009.03.008
   Fruchart JC, 2008, AM J CARDIOL, V102, p1K, DOI [10.1016/j.amjcard.2008.10.002, 10.1016/S0002-9149(08)01833-X]
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Genest J, 2004, AM J CARDIOL, V93, P848, DOI 10.1016/j.amjcard.2003.12.022
   Ginsberg HN, 2010, NEW ENGL J MED, V362, P1563, DOI 10.1056/NEJMoa1001282
   Grundy SM, 1998, AM J CARDIOL, V81, p18B, DOI 10.1016/S0002-9149(98)00033-2
   Hermans MP, 2010, CURR CARDIOL REV, V6, P112, DOI 10.2174/157340310791162686
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jang Y, 2004, AM J CLIN NUTR, V80, P832
   Jeong JS, 2017, ENDOCRINOL METAB, V32, P30, DOI 10.3803/EnM.2017.32.1.30
   Jun M, 2010, LANCET, V375, P1875, DOI 10.1016/S0140-6736(10)60656-3
   Keech A, 2005, LANCET, V366, P1849, DOI 10.1016/S0140-6736(05)67667-2
   Kim EH, 2015, CARDIOLOGY, V131, P228, DOI 10.1159/000380941
   Koopal C, 2018, DIABETES CARE, V41, P1244, DOI 10.2337/dc17-0968
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   LaRosa JC, 1999, JAMA-J AM MED ASSOC, V282, P2340, DOI 10.1001/jama.282.24.2340
   Lee JM, 2017, DIABETES METAB J, V41, P10, DOI 10.4093/dmj.2017.41.1.10
   Lévesque LE, 2010, BRIT MED J, V340, DOI 10.1136/bmj.b5087
   Lim S, 2011, DIABETES CARE, V34, P1323, DOI 10.2337/dc10-2109
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Ridker PM, 2010, LANCET, V376, P333, DOI 10.1016/S0140-6736(10)60713-1
   ROSENBAUM PR, 1983, BIOMETRIKA, V70, P41, DOI 10.1093/biomet/70.1.41
   Sabatine MS, 2017, NEW ENGL J MED, V376, P1713, DOI [10.1056/NEJMoa1615664, 10.4997/JRCPE.2017.212]
   Sampson UK, 2012, CURR ATHEROSCLER REP, V14, P1, DOI 10.1007/s11883-011-0219-7
   Schoonjans K, 1996, EMBO J, V15, P5336, DOI 10.1002/j.1460-2075.1996.tb00918.x
   Schwartz GG, 2018, NEW ENGL J MED, V379, P2097, DOI 10.1056/NEJMoa1801174
   Scott R, 2009, DIABETES CARE, V32, P493, DOI 10.2337/dc08-1543
   Seong SC, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2017-016640
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Stone NJ, 2014, CIRCULATION, V129, pS1, DOI 10.1161/01.cir.0000437738.63853.7a
   Suissa S, 2018, DIABETES CARE, V41, P6, DOI 10.2337/dc17-1223
   Tenenbaum A, 2006, CARDIOVASC DIABETOL, V5, DOI 10.1186/1475-2840-5-20
   Tenenbaum A, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-125
   Zhou Z, 2005, AM J EPIDEMIOL, V162, P1016, DOI 10.1093/aje/kwi307
NR 40
TC 52
Z9 53
U1 0
U2 9
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0959-535X
EI 1756-1833
J9 BMJ-BRIT MED J
JI BMJ-British Medical Journal
PD SEP 27
PY 2019
VL 366
AR l5125
DI 10.1136/bmj.l5125
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA JB3XM
UT WOS:000488490200001
PM 31562117
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Seale, LA
   Gilman, CL
   Hashimoto, AC
   Ogawa-Wong, AN
   Berry, MJ
AF Seale, Lucia A.
   Gilman, Christy L.
   Hashimoto, Ann C.
   Ogawa-Wong, Ashley N.
   Berry, Marla J.
TI Diet-Induced Obesity in the Selenocysteine Lyase Knockout Mouse
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Article
ID NECROSIS-FACTOR-ALPHA; HUMAN BETA-CELLS; SELENOPROTEIN-P;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; SELENIUM STATUS;
   GLUTATHIONE-PEROXIDASE; METABOLIC SYNDROME; FATTY LIVER; VITAMIN-E
AB Aims: Selenocysteine lyase (Scly) mediates selenocysteine decomposition. It was previously demonstrated that, upon adequate caloric intake (12% kcal fat) and selenium deficiency, disruption of Scly in mice leads to development of metabolic syndrome. In this study, we investigate the effect of a high-fat (45% kcal) selenium-adequate diet in Scly knockout (KO) mice on development of metabolic syndrome. Involvement of selenoproteins in energy metabolism after Scly disruption was also examined in vitro in the murine hepatoma cell line, Hepa1-6, following palmitate treatment. Results: Scly KO mice were more susceptible to diet-induced obesity than their wild-type counterparts after feeding a high-fat selenium-adequate diet. Scly KO mice had aggravated hyperinsulinemia, hypercholesterolemia, glucose, and insulin intolerance, but unchanged inflammatory cytokines and expression of most selenoproteins, except increased serum selenoprotein P (Sepp1). Scly KO mice also exhibited enhanced hepatic levels of pyruvate and enzymes involved in the regulation of pyruvate cycling, such as pyruvate carboxylase (Pcx) and pyruvate dehydrogenase (Pdh). However, in vitro silencing of Scly in Hepa1-6 cells led to diminished Sepp1 expression, and concomitant palmitate treatment decreased Pdh expression. Innovation: The role of selenium in lipid metabolism is recognized, but specific selenium-dependent mechanisms leading to obesity are unclear. This study uncovers that Scly has a remarkable effect on obesity and metabolic syndrome development triggered by high-fat exposure, independent of the expression of most selenoproteins. Conclusion: Diet-induced obesity in Scly KO mice is aggravated, with effects on pyruvate levels and consequent activation of energy metabolism independent of selenoprotein levels. Antioxid. Redox Signal. 23, 761-774.
C1 [Seale, Lucia A.; Gilman, Christy L.; Hashimoto, Ann C.; Ogawa-Wong, Ashley N.; Berry, Marla J.] Univ Hawaii Manoa, John A Burns Sch Med, Dept Cell & Mol Biol, Honolulu, HI 96813 USA.
C3 University of Hawaii System; University of Hawaii Manoa
RP Seale, LA (corresponding author), Univ Hawaii Manoa, John A Burns Sch Med, Dept Cell & Mol Biol, 651 Ilalo St,BSB222, Honolulu, HI 96813 USA.
EM lseale@hawaii.edu
RI Seale, Lucia/AFT-9036-2022
OI Seale, Lucia/0000-0002-0686-7516
FU National Institutes of Health [R01-DK47320, G12-MD007601]; Pilot Project
   Award [G12-MD007601]
FX This work was funded by the National Institutes of Health, grants
   R01-DK47320 and G12-MD007601 to MJB, and Pilot Project Award funds from
   G12-MD007601 to LAS. Image of WT and Scly KO mice in Figure 1A was a
   courtesy of Ann Hashimoto. We thank FuKun Hoffmann, Maile O'Connell,
   Madhuri Namekar, Brooks Mitchell, and the COBRE Molecular and Cellular
   Immunology Core Facility at the University of Hawaii for helping with
   flow cytometry, and Dr. Frederick Bellinger for providing the mouse
   Sepp1 antibody. LAS designed and performed experiments, analyzed data,
   and wrote the article. ACH, ANO, and CLG performed experiments, analyzed
   data, and contributed with analytical tools. MJB mentored in all
   research steps. All authors discussed and reviewed the article.
CR Alasfar F, 2011, OBES SURG, V21, P1710, DOI 10.1007/s11695-011-0458-2
   Buettner R, 2006, J MOL ENDOCRINOL, V36, P485, DOI 10.1677/jme.1.01909
   Burk RF, 2009, BBA-GEN SUBJECTS, V1790, P1441, DOI 10.1016/j.bbagen.2009.03.026
   Burk RF, 2005, ANNU REV NUTR, V25, P215, DOI 10.1146/annurev.nutr.24.012003.132120
   Busch AK, 2002, DIABETES, V51, P977, DOI 10.2337/diabetes.51.4.977
   Calder PC, 2011, BRIT J NUTR, V106, pS1, DOI 10.1017/S0007114511005460
   Chanoine JP, 2004, BIOFACTORS, V20, P109, DOI 10.1002/biof.5520200205
   Combs GF, 2015, NUTRIENTS, V7, P2209, DOI 10.3390/nu7042209
   Curran JE, 2005, NAT GENET, V37, P1234, DOI 10.1038/ng1655
   DEAGEN JT, 1987, J NUTR, V117, P91, DOI 10.1093/jn/117.1.91
   Ericson U, 2015, AM J CLIN NUTR, V101, P1065, DOI 10.3945/ajcn.114.103010
   GJORUP I, 1988, SCAND J GASTROENTERO, V23, P1250, DOI 10.3109/00365528809090200
   Hellwege JN, 2014, GENE, V534, P33, DOI 10.1016/j.gene.2013.10.035
   Henry BA, 2008, J NEUROENDOCRINOL, V20, P842, DOI 10.1111/j.1365-2826.2008.1730.x
   HILL KE, 1992, BIOCHEM BIOPH RES CO, V185, P260, DOI 10.1016/S0006-291X(05)80984-2
   Hoffmann FW, 2010, J NUTR, V140, P1155, DOI 10.3945/jn.109.120725
   Hoffmann PR, 2007, NUCLEIC ACIDS RES, V35, P3963, DOI 10.1093/nar/gkm355
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Huggett JF, 2013, CLIN CHEM, V59, P892, DOI 10.1373/clinchem.2013.206375
   Jung TW, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0066529
   Kadowaki T, 2002, J DIABETES COMPLICAT, V16, P41, DOI 10.1016/S1056-8727(01)00206-9
   Kaur P, 2004, J BIOMED SCI, V11, P391, DOI 10.1159/000077108
   Kaur P, 2004, ASIAN J ANDROL, V6, P227
   Kim JE, 2012, BIOL TRACE ELEM RES, V150, P360, DOI 10.1007/s12011-012-9519-1
   Kimmons Joel E, 2006, MedGenMed, V8, P59
   Kobayashi Y, 2002, P NATL ACAD SCI USA, V99, P15932, DOI 10.1073/pnas.252610699
   Kong D, 2012, CELL, V151, P645, DOI 10.1016/j.cell.2012.09.020
   Kurokawa S, 2011, J NUTR SCI VITAMINOL, V57, P298, DOI 10.3177/jnsv.57.298
   Kwak MS, 2003, J MOL CATAL B-ENZYM, V23, P367, DOI 10.1016/S1381-1177(03)00100-0
   Labunskyy VM, 2014, PHYSIOL REV, V94, P739, DOI 10.1152/physrev.00039.2013
   Lei XG, 2011, ANTIOXID REDOX SIGN, V14, P489, DOI 10.1089/ars.2010.3416
   Letsiou S, 2014, BIOFACTORS, V40, P524, DOI 10.1002/biof.1176
   Lietz G, 2009, CURR OPIN LIPIDOL, V20, P112, DOI 10.1097/MOL.0b013e3283295ecf
   Lundåsen T, 2003, J BIOL CHEM, V278, P43224, DOI 10.1074/jbc.M302645200
   Marchesini G, 2001, DIABETES, V50, P1844, DOI 10.2337/diabetes.50.8.1844
   MARK DA, 1984, AM J PATHOL, V117, P125
   Marsili A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020832
   Matsuda M, 2014, REV ENDOCR METAB DIS, V15, P1, DOI 10.1007/s11154-013-9271-7
   Medina MC, 2011, ENDOCRINOLOGY, V152, P3717, DOI 10.1210/en.2011-1210
   Mihalca R, 2014, J Med Life, V7, P296
   Milagro FI, 2006, OBESITY, V14, P1118, DOI 10.1038/oby.2006.128
   Misu H, 2010, CELL METAB, V12, P483, DOI 10.1016/j.cmet.2010.09.015
   Murao K, 2008, AM J PHYSIOL-ENDOC M, V294, pE78, DOI 10.1152/ajpendo.00023.2007
   Olsson M, 2011, METABOLISM, V60, P114, DOI 10.1016/j.metabol.2010.05.011
   Oswal A, 2010, OBESITY, V18, P221, DOI 10.1038/oby.2009.228
   Ozata M, 2000, HORM METAB RES, V32, P269, DOI 10.1055/s-2007-978634
   Prevost G, 2013, ENDOCRINOLOGY, V154, P3796, DOI 10.1210/en.2013-1167
   Raman AV, 2012, GENES BRAIN BEHAV, V11, P601, DOI 10.1111/j.1601-183X.2012.00794.x
   Ren XM, 2012, FOOD CHEM TOXICOL, V50, P3521, DOI 10.1016/j.fct.2012.07.021
   Reszka E, 2012, GENES NUTR, V7, P127, DOI 10.1007/s12263-011-0246-6
   Sachithanandan N, 2010, HEPATOLOGY, V52, P1632, DOI 10.1002/hep.23861
   Saito Y, 1999, J BIOL CHEM, V274, P2866, DOI 10.1074/jbc.274.5.2866
   Schomburg L, 2009, BBA-GEN SUBJECTS, V1790, P1453, DOI 10.1016/j.bbagen.2009.03.015
   Seale LA, 2012, MOL CELL BIOL, V32, P4141, DOI 10.1128/MCB.00293-12
   Sengupta A, 2008, BIOCHEM BIOPH RES CO, V365, P446, DOI 10.1016/j.bbrc.2007.10.189
   Shetty SP, 2014, J BIOL CHEM, V289, P25317, DOI 10.1074/jbc.M114.590430
   Shi HF, 2009, FRONT NEUROENDOCRIN, V30, P396, DOI 10.1016/j.yfrne.2009.03.004
   Souza SC, 1998, DIABETES, V47, P691, DOI 10.2337/diabetes.47.4.691
   Speckmann B, 2015, EPIGENETICS-US, V10, P179, DOI 10.1080/15592294.2015.1013792
   Speckmann B, 2008, HEPATOLOGY, V48, P1998, DOI 10.1002/hep.22526
   Stapleton SR, 2000, CELL MOL LIFE SCI, V57, P1874, DOI 10.1007/PL00000669
   Steinbrenner H, 2011, J CLIN BIOCHEM NUTR, V48, P40, DOI 10.3164/jcbn.11-002FR
   STONE WL, 1986, ANN NUTR METAB, V30, P94, DOI 10.1159/000177181
   STONE WL, 1994, P SOC EXP BIOL MED, V206, P130, DOI 10.3181/00379727-206-43731
   Stranges S, 2011, J INTERN MED, V270, P469, DOI 10.1111/j.1365-2796.2011.02398.x
   Stryjecki C, 2011, EUR J CLIN NUTR, V65, P285, DOI 10.1038/ejcn.2010.277
   Sunde RA, 2009, BIOSCIENCE REP, V29, P329, DOI 10.1042/BSR20080146
   Tobe R, 2009, BIOSCI BIOTECH BIOCH, V73, P1230, DOI 10.1271/bbb.90065
   Vinceti M, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005195.pub3
   WADE GN, 1986, ANN NY ACAD SCI, V474, P389, DOI 10.1111/j.1749-6632.1986.tb28029.x
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yang SJ, 2011, J CLIN ENDOCR METAB, V96, pE1325, DOI 10.1210/jc.2011-0620
   Yang XP, 2013, J LIPID RES, V54, P2450, DOI 10.1194/jlr.M038877
   Zeng MS, 2012, FREE RADICAL BIO MED, V52, P1335, DOI 10.1016/j.freeradbiomed.2012.01.017
NR 75
TC 34
Z9 36
U1 0
U2 27
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD OCT 1
PY 2015
VL 23
IS 10
BP 761
EP 774
DI 10.1089/ars.2015.6277
PG 14
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA CS0LI
UT WOS:000361750400002
PM 26192035
OA Green Published
DA 2025-06-11
ER

PT J
AU Huzen, J
   Wong, LSM
   van Veldhuisen, DJ
   Samani, NJ
   Zwinderman, AH
   Codd, V
   Cawthon, RM
   Benus, GFJD
   van der Horst, ICC
   Navis, G
   Bakker, SJL
   Gansevoort, RT
   de Jong, PE
   Hillege, HL
   van Gilst, WH
   de Boer, RA
   van der Harst, P
AF Huzen, J.
   Wong, L. S. M.
   van Veldhuisen, D. J.
   Samani, N. J.
   Zwinderman, A. H.
   Codd, V.
   Cawthon, R. M.
   Benus, G. F. J. D.
   van der Horst, I. C. C.
   Navis, G.
   Bakker, S. J. L.
   Gansevoort, R. T.
   de Jong, P. E.
   Hillege, H. L.
   van Gilst, W. H.
   de Boer, R. A.
   van der Harst, P.
TI Telomere length loss due to smoking and metabolic traits
SO JOURNAL OF INTERNAL MEDICINE
LA English
DT Article
DE ageing; biomarker; metabolic syndrome; smoking; telomeres
ID CORONARY-ARTERY-DISEASE; OXIDATIVE STRESS; LONGITUDINAL FINDINGS; HEART;
   ASSOCIATION; MORTALITY; DYNAMICS; BLOOD; LIFE
AB ObjectivesHuman age-dependent telomere attrition and telomere shortening are associated with several age-associated diseases and poorer overall survival. The aim of this study was to determine longitudinal leucocyte telomere length dynamics and identify factors associated with temporal changes in telomere length.
   Design and MethodsLeucocyte telomere length was measured by quantitative polymerase chain reaction in 8074 participants from the Prevention of Renal and Vascular End-stage Disease (PREVEND) study, an ongoing community-based prospective cohort study initiated in 1997. Follow-up data were available at two time-points up to 2007. Leucocyte telomere length was measured, on between one and three separate occasions, in a total of 16783 DNA samples. Multilevel growth models were created to identify the factors that influence leucocyte telomere dynamics.
   ResultsWe observed an average attrition rate of 0.470.16 relative telomere length units (RTLUs) per year in the study population aged 48 (range 39-60) years at baseline. Annual telomere attrition rate increased with age (P<0.001) and was faster on average in men than in women (P for interaction 0.043). The major independent factors determining telomere attrition rate were active smoking (approximately tripled the loss of RTLU per year, P<0.0001) and multiple traits of the metabolic syndrome (waist-hip ratio, P=0.007; blood glucose level, P=0.045, and HDL cholesterol level, P<0.001).
   ConclusionsSmoking and variables linked to the metabolic syndrome are modifiable lifestyle factors that accelerate telomere attrition in humans. The higher rate of cellular ageing may mediate the link between smoking and the metabolic syndrome to an increased risk of several age-associated diseases.
C1 [Huzen, J.; Wong, L. S. M.; van Veldhuisen, D. J.; Benus, G. F. J. D.; van der Horst, I. C. C.; Hillege, H. L.; van Gilst, W. H.; de Boer, R. A.; van der Harst, P.] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands.
   [Samani, N. J.; Codd, V.] Univ Leicester, Glenfield Hosp, Dept Cardiovasc Sci, Leicester, Leics, England.
   [Zwinderman, A. H.] Univ Amsterdam, Acad Med Ctr, Dept Clin Epidemiol & Biostat, NL-1105 AZ Amsterdam, Netherlands.
   [Cawthon, R. M.] Univ Utah, Dept Human Genet, Salt Lake City, UT USA.
   [Navis, G.; Bakker, S. J. L.; Gansevoort, R. T.; de Jong, P. E.] Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Groningen, Netherlands.
   [van der Harst, P.] ICIN Netherlands Heart Inst, Durrer Ctr Cardiogenet Res, Utrecht, Netherlands.
C3 University of Groningen; University Hospitals of Leicester NHS Trust;
   University of Leicester; Glenfield Hospital; University of Amsterdam;
   Academic Medical Center Amsterdam; Utah System of Higher Education;
   University of Utah; University of Groningen
RP van der Harst, P (corresponding author), Univ Med Ctr Groningen, Dept Cardiol, Hanzepl 1, NL-9700 RB Groningen, Netherlands.
EM p.van.der.harst@umcg.nl
RI van Veldhuisen, Dirk/E-8967-2014; van Gilst, Wiek/AFM-7606-2022; van der
   Horst, Iwan/AFU-8433-2022; van der Harst, Pim/HOH-5622-2023; Bakker,
   Stephan/J-4023-2015; de Boer, Rudolf/HMW-1849-2023
OI Codd, Veryan/0000-0002-9430-8254; van der Harst,
   Pim/0000-0002-2713-686X; Bakker, Stephan/0000-0003-3356-6791; de Boer,
   Rudolf/0000-0002-4775-9140; van Gilst, Wiek/0000-0003-2968-8585
FU Netherlands Heart Foundation [2006B140, 2006T003, 2008T028];
   Innovational Research Incentives Scheme of the Netherlands Organization
   for Scientific Research (NWO VENI) [916.76.170]; British Heart
   Foundation; Leicester NIHR Bio-medical Research Unit in Cardiovascular
   Disease
FX This work was supported by grants from the Netherlands Heart Foundation
   (Grant Numbers 2006B140, 2006T003, 2008T028) and the Innovational
   Research Incentives Scheme of the Netherlands Organization for
   Scientific Research (NWO VENI, Grant Number 916.76.170 to PvdH). PvdH is
   a research fellow of the Interuniversity Cardiology Institute of the
   Netherlands (ICIN). NJS holds a Chair funded by the British Heart
   Foundation, and NJS and VC are supported by the Leicester NIHR
   Bio-medical Research Unit in Cardiovascular Disease.
CR Artandi SE, 2006, NEW ENGL J MED, V355, P1195, DOI 10.1056/NEJMp068187
   Aviv A, 2009, AM J EPIDEMIOL, V169, P323, DOI 10.1093/aje/kwn338
   Blackburn EH, 2010, ANGEW CHEM INT EDIT, V49, P7405, DOI 10.1002/anie.201002387
   Brouilette S, 2003, ARTERIOSCL THROM VAS, V23, P842, DOI 10.1161/01.ATV.0000067426.96344.32
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Cawthon RM, 2009, NUCLEIC ACIDS RES, V37, DOI 10.1093/nar/gkn1027
   Cawthon RM, 2003, LANCET, V361, P393, DOI 10.1016/S0140-6736(03)12384-7
   Chen W, 2011, J GERONTOL A-BIOL, V66, P312, DOI 10.1093/gerona/glq223
   Chen W, 2009, ATHEROSCLEROSIS, V205, P620, DOI 10.1016/j.atherosclerosis.2009.01.021
   Codd V, 2013, NAT GENET, V45, P422, DOI 10.1038/ng.2528
   Codd V, 2010, NAT GENET, V42, P197, DOI 10.1038/ng.532
   Demissie S, 2006, AGING CELL, V5, P325, DOI 10.1111/j.1474-9726.2006.00224.x
   Ehrlenbach S, 2009, INT J EPIDEMIOL, V38, P1725, DOI 10.1093/ije/dyp273
   Epel ES, 2010, BRAIN BEHAV IMMUN, V24, P531, DOI 10.1016/j.bbi.2009.11.018
   Farzaneh-Far R, 2008, ARTERIOSCL THROM VAS, V28, P1379, DOI 10.1161/ATVBAHA.108.167049
   Farzaneh-Far R, 2010, JAMA-J AM MED ASSOC, V303, P250, DOI 10.1001/jama.2009.2008
   Farzaneh-Far R, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008612
   Fitzpatrick AL, 2011, J GERONTOL A-BIOL, V66, P421, DOI 10.1093/gerona/glq224
   Hillege HL, 2002, CIRCULATION, V106, P1777, DOI 10.1161/01.CIR.0000031732.78052.81
   Hunt SC, 2008, AGING CELL, V7, P451, DOI 10.1111/j.1474-9726.2008.00397.x
   Jaskelioff M, 2011, NATURE, V469, P102, DOI 10.1038/nature09603
   Lee M, 2011, AM J HUM BIOL, V23, P100, DOI 10.1002/ajhb.21109
   Levey AS, 1999, ANN INTERN MED, V130, P461, DOI 10.7326/0003-4819-130-6-199903160-00002
   Lin J, 2010, J IMMUNOL METHODS, V352, P71, DOI 10.1016/j.jim.2009.09.012
   NAKAYAMA T, 1985, NATURE, V314, P462, DOI 10.1038/314462a0
   Navab M, 2004, J LIPID RES, V45, P993, DOI 10.1194/jlr.R400001-JLR200
   Njajou OT, 2009, J GERONTOL A-BIOL, V64, P860, DOI 10.1093/gerona/glp061
   O'Donovan A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019687
   Pou KM, 2007, CIRCULATION, V116, P1234, DOI 10.1161/CIRCULATIONAHA.107.710509
   Puterman E, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010837
   Samani NJ, 2001, LANCET, V358, P472, DOI 10.1016/S0140-6736(01)05633-1
   Serra V, 2000, ANN NY ACAD SCI, V908, P327
   Svenson U, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0021485
   Valdes AM, 2005, LANCET, V366, P662, DOI 10.1016/S0140-6736(05)66630-5
   van der Harst P, 2007, J AM COLL CARDIOL, V49, P1459, DOI 10.1016/j.jacc.2007.01.027
   van der Harst P, 2010, ANN MED, V42, P36, DOI 10.3109/07853890903321567
   Walter M, 2009, ARTERIOSCL THROM VAS, V29, P1244, DOI 10.1161/ATVBAHA.108.181438
   Wang MC, 2003, DEV CELL, V5, P811, DOI 10.1016/S1534-5807(03)00323-X
   Willeit P, 2011, JAMA-J AM MED ASSOC, V306, P42, DOI 10.1001/jama.2011.901
   Zhu HD, 2011, CLIN SCI, V120, P427, DOI 10.1042/CS20100385
NR 40
TC 145
Z9 158
U1 3
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0954-6820
EI 1365-2796
J9 J INTERN MED
JI J. Intern. Med.
PD FEB
PY 2014
VL 275
IS 2
BP 155
EP 163
DI 10.1111/joim.12149
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 290NG
UT WOS:000329764500007
PM 24118582
OA hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Schilling, R
   Colledge, F
   Pühse, U
   Gerber, M
AF Schilling, Rene
   Colledge, Flora
   Puehse, Uwe
   Gerber, Markus
TI Stress-buffering effects of physical activity and cardiorespiratory
   fitness on metabolic syndrome: A prospective study in police officers
SO PLOS ONE
LA English
DT Article
ID EFFORT-REWARD IMBALANCE; CORONARY-HEART-DISEASE; CARDIOVASCULAR
   RISK-FACTOR; OF-THE-ART; PERCEIVED STRESS; HAIR CORTISOL; WORK; HEALTH;
   PREVALENCE; FREQUENCY
AB Metabolic syndrome (MetS) is a worldwide health concern related to cardiovascular disease. Stress at work increases the risk for MetS, whereas physical activity and cardiorespiratory fitness (CF) have been shown to be potential buffers against stress. The aim of this study was to test the stress-buffering effects of physical activity and CF on the relationship between work stress and MetS. In a prospective study, we followed 97 police officers (mean age = 39.7 years; mean body mass index = 25.74 kg/m(2)) over one year and assessed MetS, as defined by the National Cholesterol Education Program Adult Treatment Panel III. Stress at work was measured with the Job Content Questionnaire, as well as the Effort-Reward Imbalance Questionnaire. Physical activity was assessed objectively via 7-day accelerometry. CF was assessed with the angstrom strand bicycle ergometer test. Hierarchical linear regression models were carried out to predict MetS at follow-up (mean overall MetS score = 1.22), after controlling for baseline levels and sociodemographic background (mean overall MetS score = 1.19). Higher CF levels were significantly associated with lower MetS risk at follow-up (beta = -.38). By contrast, no main effects were found for physical activity and work stress. However, high effort and demand were significantly correlated with increased blood pressure (effort:r= .23 for systolic blood pressure;r= .21 for diastolic blood pressure) and waist circumference (effort:r= .26; demand:r= .23). Moreover, no significant interaction effects occurred between work stress and CF/physical activity. The results emphasize the importance of high levels of CF in the prevention of MetS in police officers. Accordingly, provision of regular training opportunities and repeated CF testing should be considered as a strategy in overall corporate health promotion.
C1 [Schilling, Rene; Colledge, Flora; Puehse, Uwe; Gerber, Markus] Univ Basel, Dept Sport Exercise & Hlth, Basel, Switzerland.
C3 University of Basel; Swiss School of Public Health (SSPH+)
RP Schilling, R (corresponding author), Univ Basel, Dept Sport Exercise & Hlth, Basel, Switzerland.
EM rene.schilling@unibas.ch
RI Gerber, Markus/H-8654-2014
OI vandoni, matteo/0000-0002-3405-9364
CR Aiken LS., 1991, Multiple regression: Testing and interpreting interactions, pxi
   American Psychological Association, 2017, Stress in America: The state of our nation
   Carayon P, 1999, WORK STRESS, V13, P32, DOI 10.1080/026783799296174
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Charles LE, 2008, OBESITY, V16, P2489, DOI 10.1038/oby.2008.395
   Clarke J, 2013, APPL PHYSIOL NUTR ME, V38, P773, DOI 10.1139/apnm-2013-0049
   Davila EP, 2010, DIABETES CARE, V33, P2390, DOI 10.2337/dc10-0681
   Dragano N, 2017, EPIDEMIOLOGY, V28, P619, DOI 10.1097/EDE.0000000000000666
   Eriksson AK, 2013, DIABETOLOGE, V9, P438, DOI 10.2337/dc12-1738
   Ferguson B., 2014, J CANADIAN CHIROPRAC, V58, P328
   Folsom AR, 1997, MED SCI SPORT EXER, V29, P901, DOI 10.1097/00005768-199707000-00009
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   Foss MLK, 1998, SJ FOXS PHYSL BASIS
   Franke WD, 2010, J OCCUP ENVIRON MED, V52, P561, DOI 10.1097/JOM.0b013e3181dd086b
   Franks PW, 2004, DIABETES CARE, V27, P1187, DOI 10.2337/diacare.27.5.1187
   Fuchs R., 2018, Handbuch Stressregulation und Sport, P3, DOI DOI 10.1007/978-3-662-49322-9_26
   Garbarino S, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0144318
   Gaziano T., 2012, BRUNWALDS HEART DIS, V9th
   Gaziano TA, 2010, CURR PROB CARDIOLOGY, V35, P72, DOI 10.1016/j.cpcardiol.2009.10.002
   Gerber M., 2018, HDB STRESSREGULATION, P93, DOI [DOI 10.1007/978-3-662-49322-9_5, 10.1007/978-3-662-49322-9_5]
   Gerber M., 2020, SPORTPSYCHOLOGIE, P581, DOI DOI 10.1007/978-3-662-56802-6_25
   Gerber M, 2017, MED SCI SPORT EXER, V49, P581, DOI 10.1249/MSS.0000000000001123
   Gerber M, 2016, MED SCI SPORT EXER, V48, P2075, DOI 10.1249/MSS.0000000000001005
   Gerber M, 2013, J OCCUP HEALTH, V55, P376, DOI 10.1539/joh.13-0030-OA
   Gerber M, 2013, NEUROPSYCHOBIOLOGY, V68, P100, DOI 10.1159/000351735
   Gerber M, 2012, J SPORT SCI MED, V11, P571
   Gerber M, 2010, J CRIM JUST, V38, P1167, DOI 10.1016/j.jcrimjus.2010.09.005
   Gerber M, 2010, PSYCHOL SPORT EXERC, V11, P286, DOI 10.1016/j.psychsport.2010.02.004
   Gerber M, 2009, SCAND J PUBLIC HEALT, V37, P801, DOI 10.1177/1403494809350522
   Gharbi A, 2008, 2008 5TH INTERNATIONAL SUMMER SCHOOL AND SYMPOSIUM ON MEDICAL DEVICES AND BIOSENSORS, P136, DOI 10.1109/ISSMDBS.2008.4575024
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Guthold R, 2018, LANCET GLOB HEALTH, V6, pE1077, DOI [10.1016/S2214-109X(18)30357-7, 10.1016/s2214-109x(18)30357-7]
   Habersaat SA, 2015, SOC SCI MED, V143, P213, DOI 10.1016/j.socscimed.2015.08.043
   Härtel S, 2011, EUR REV AGING PHYS A, V8, P109, DOI 10.1007/s11556-010-0074-5
   Hartley Tara A, 2011, Int J Emerg Ment Health, V13, P243
   Hjemdahl P, 2002, CIRCULATION, V106, P2634, DOI 10.1161/01.CIR.0000041502.43564.79
   Holmes M., 2017, HDB STRESSREGULATION, P311
   Humbarger CD, 2004, MED SCI SPORT EXER, V36, pS161, DOI 10.1097/00005768-200405001-00767
   Jain A, 2017, ANN CLIN BIOCHEM, V54, P331, DOI 10.1177/0004563216661737
   Joo G.Y., 2017, Korean J. Fam. Pract, V7, P726, DOI [10.21215/kjfp.2017.7.5.726, DOI 10.21215/KJFP.2017.7.5.726]
   Kaltsas GA, 2007, HANDBOOK OF PSYCHOPHYSIOLOGY, 3RD EDITION, P303
   Karasek R, 1998, J Occup Health Psychol, V3, P322, DOI 10.1037/1076-8998.3.4.322
   KARASEK RA, 1979, ADMIN SCI QUART, V24, P285, DOI 10.2307/2392498
   Karasek RA, 1990, Healthy work: Stress, productivity, and the reconstruction of working life
   Kasten N., 2018, HDB STRESSREGULATION, P1
   Kivimäki M, 2018, NAT REV CARDIOL, V15, P215, DOI 10.1038/nrcardio.2017.189
   Klaperski S., 2018, Stressregulation und Sport, DOI [DOI 10.1007/9783-66249322-98, DOI 10.1007/978-3-662-49322-9_8]
   Lagrand WK, 1999, CIRCULATION, V100, P96, DOI 10.1161/01.CIR.100.1.96
   Landsbergis P, 2018, OCCUPATIONAL ENV HLT, V7, P325
   Lee RS, 2014, NEUROENDOCRINOLOGY, V100, P278, DOI 10.1159/000369585
   Lloyd-Jones DM, 2010, CIRCULATION, V121, P586, DOI 10.1161/CIRCULATIONAHA.109.192703
   Loerbroks A, 2015, INT J CARDIOL, V182, P390, DOI 10.1016/j.ijcard.2015.01.030
   Magnavita N, 2018, INT ARCH OCC ENV HEA, V91, P377, DOI 10.1007/s00420-018-1290-y
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Mozumdar A, 2011, DIABETES CARE, V34, P216, DOI 10.2337/dc10-0879
   Myers J, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071652
   Nordgren B, 2014, BMC MUSCULOSKEL DIS, V15, DOI 10.1186/1471-2474-15-305
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Puterman E, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010837
   Ross R, 2016, CIRCULATION, V134, pE653, DOI 10.1161/CIR.0000000000000461
   Russ Tom C, 2012, BMJ, V345, pe4933, DOI 10.1136/bmj.e4933
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sara JD, 2018, J AM HEART ASSOC, V7, DOI 10.1161/JAHA.117.008073
   Shane JM, 2010, J CRIM JUST, V38, P807, DOI 10.1016/j.jcrimjus.2010.05.008
   Siegrist J, 2004, SOC SCI MED, V58, P1483, DOI 10.1016/S0277-9536(03)00351-4
   Siegrist J, 2005, PSYCHONEUROENDOCRINO, V30, P1033, DOI 10.1016/j.psyneuen.2005.03.017
   Siegrist J, 1996, J Occup Health Psychol, V1, P27, DOI 10.1037/1076-8998.1.1.27
   Silverman MN, 2014, INTERFACE FOCUS, V4, DOI 10.1098/rsfs.2014.0040
   Stalder T, 2012, BRAIN BEHAV IMMUN, V26, P1019, DOI 10.1016/j.bbi.2012.02.002
   strand P-O, 2003, TXB WORK PHYSL PHYSL, P1
   THOMAS S, 1992, CAN J SPORT SCI, V17, P338
   Troiano RP, 2008, MED SCI SPORT EXER, V40, P181, DOI 10.1249/mss.0b013e31815a51b3
   Van der Doef M, 1999, WORK STRESS, V13, P87, DOI 10.1080/026783799296084
   Violanti John M, 2017, Policing, V40, P642, DOI 10.1108/PIJPSM-06-2016-0097
   Violanti JM, 2017, PSYCHONEUROENDOCRINO, V75, P124, DOI 10.1016/j.psyneuen.2016.10.017
   Violanti JM, 2009, ARCH ENVIRON OCCUP H, V64, P194, DOI 10.1080/19338240903241259
   Warburton DER, 2006, CAN MED ASSOC J, V174, P801, DOI 10.1503/cmaj.051351
   WHO, 2010, WHO GUID DRAWING BLO
   World Health Organization, 2011, Waist circumference and waist-hip ratio: report of a WHO expert consultation
   Yoo HL, 2009, J OCCUP ENVIRON MED, V51, P46, DOI 10.1097/JOM.0b013e31817f9e43
   YOUNG DR, 1994, J PSYCHOSOM RES, V38, P451, DOI 10.1016/0022-3999(94)90106-6
   ,, 2010, Global recommendations on physical activity for health
NR 82
TC 11
Z9 13
U1 0
U2 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 28
PY 2020
VL 15
IS 7
AR e0236526
DI 10.1371/journal.pone.0236526
PG 21
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA MW3BD
UT WOS:000556916000042
PM 32722703
OA Green Accepted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Chien, YH
   Yu, YH
   Chen, YW
AF Chien, Yi-Hsuan
   Yu, Yu-Hsiang
   Chen, Yue-Wen
TI Taiwanese green propolis ameliorates metabolic syndrome via remodeling
   of white adipose tissue and modulation of gut microbiota in diet-induced
   obese mice
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Taiwanese green propolis; White adipose tissue; Brown adipose tissue;
   Metabolic syndrome; Gut microbiota
ID INSULIN-RESISTANCE; LIPID-METABOLISM; FAT ACCUMULATION; PLANT-ORIGIN;
   BROWN FAT; PATHOGENESIS; POLYPHENOLS; APOPTOSIS; ADIPOKINE; BENEFITS
AB Excessive energy intake leads to dysbiosis of intestinal microbiota and puts surrounding tissues under oxidative stress and inflammation, contributing to the development of metabolic syndrome. Taiwanese green propolis (TGP) exhibits a broad spectrum of biological activities, including anti-bacterial, anti-inflammatory, and antioxidant properties. However, the benefits of TGP on metabolic syndrome have not been explained in detail. In this study, we examined the preventive effects of TGP on high-fat diet (HFD)-induced obesity. The results showed that TGP supplementation at 1000 ppm improved condition such as hyperlipidemia, fat accumulation, liver steatosis, and whitening of brown adipose tissue (BAT) in mice. In addition, we observed more cold-induced nonshivering thermogenesis by BAT in TGP treatment with 1000 ppm group. At lower dose of 500 ppm, TGP improved glucose intolerance and insulin insensitivity in HFD mice and restructured the composition of gut microbiota to reduce dysbiosis, which involved an increase in the abundance of metabolism-related bacteria such as Lachnospiraceae NK4A136 group and the decrease in Desulfovibrio. The change of dominant microbiota was associated with the homeostasis of blood glucose and lipid. Transcriptome and micro-western array analysis revealed that TGP supplementation at 500 ppm promoted the browning and adipogenesis in white adipose tissue (WAT), blocked inflammation signaling and attenuated reactive oxygen species, contributing to healthy WAT remodeling and offsetting negative metabolic effects of obesity. We concluded that TGP modulated the function of BAT, WAT, and gut microbiota, bringing a balance to the glucose and lipid homeostasis in the body.
C1 [Chien, Yi-Hsuan; Yu, Yu-Hsiang; Chen, Yue-Wen] Natl Ilan Univ, Dept Biotechnol & Anim Sci, Yilan, Taiwan.
   [Chien, Yi-Hsuan; Yu, Yu-Hsiang; Chen, Yue-Wen] Natl Ilan Univ, Res Ctr Honey Bee & Bee Prod, Yilan, Taiwan.
C3 National Ilan University; National Ilan University
RP Yu, YH; Chen, YW (corresponding author), Natl Ilan Univ, Dept Biotechnol & Anim Sci, Yilan, Taiwan.; Yu, YH; Chen, YW (corresponding author), Natl Ilan Univ, Res Ctr Honey Bee & Bee Prod, Yilan, Taiwan.
EM yuyh@niu.edu.tw; chenyw@niu.edu.tw
RI Yu, Yu-Hsiang/J-4424-2019
OI Yu, Yu-Hsiang/0000-0001-9629-8478
CR Blüher M, 2019, NAT REV ENDOCRINOL, V15, P288, DOI 10.1038/s41574-019-0176-8
   Bolger AM, 2014, BIOINFORMATICS, V30, P2114, DOI 10.1093/bioinformatics/btu170
   Caballero B, 2007, EPIDEMIOL REV, V29, P1, DOI 10.1093/epirev/mxm012
   Cai W, 2020, FOOD RES INT, V130, DOI 10.1016/j.foodres.2019.108939
   Cannon B, 2011, J EXP BIOL, V214, P242, DOI 10.1242/jeb.050989
   Cardona F, 2013, J NUTR BIOCHEM, V24, P1415, DOI 10.1016/j.jnutbio.2013.05.001
   Chen CN, 2007, CANCER LETT, V245, P218, DOI 10.1016/j.canlet.2006.01.016
   Chen CT, 2019, JOVE-J VIS EXP, DOI 10.3791/58743
   Chen CN, 2003, J NAT PROD, V66, P503, DOI 10.1021/np0203180
   Chen JY, 2021, POULTRY SCI, V100, P875, DOI 10.1016/j.psj.2020.10.070
   Chen LH, 2018, NUTRIENTS, V10, DOI 10.3390/nu10040503
   Chen YW, 2020, J FUNCT FOODS, V73, DOI 10.1016/j.jff.2020.104135
   Cheru L, 2019, CURR OBES REP, V8, P165, DOI 10.1007/s13679-019-00332-6
   Chien YH, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11071242
   Choi JW, 2016, DIABETOLOGIA, V59, P571, DOI 10.1007/s00125-015-3836-9
   Chondronikola M., Diabetes
   Ciaccio MF, 2010, NAT METHODS, V7, P148, DOI [10.1038/NMETH.1418, 10.1038/nmeth.1418]
   Cueva C., 2016, WINE SAFETY CONSUMER, P259, DOI [10.1007/978-3-319-24514-0, DOI 10.1007/978-3-319-24514-0]
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   Duda-Chodak A, 2015, EUR J NUTR, V54, P325, DOI 10.1007/s00394-015-0852-y
   Echeverria F., J NUTR BIOCHEM
   Fedorenko A, 2012, CELL, V151, P400, DOI 10.1016/j.cell.2012.09.010
   Heimann E, 2016, ADIPOCYTE, V5, P359, DOI 10.1080/21623945.2016.1252011
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Hotamisligil GS, 2008, NAT REV IMMUNOL, V8, P923, DOI 10.1038/nri2449
   Hsiao FSH, 2022, ANIMALS-BASEL, V12, DOI 10.3390/ani12040446
   Hsieh CY, 2019, J CELL PHYSIOL, V234, P4081, DOI 10.1002/jcp.27204
   Huang WJ, 2007, J AGR FOOD CHEM, V55, P7366, DOI 10.1021/jf0710579
   Ichi I, 2009, J FOOD SCI, V74, pH127, DOI 10.1111/j.1750-3841.2009.01147.x
   Illesca P, 2020, FOOD FUNCT, V11, P9086, DOI [10.1039/d0fo01790f, 10.1039/D0FO01790F]
   Illesca P, 2020, MOLECULES, V25, DOI 10.3390/molecules25194433
   Illesca P, 2019, BIOMED PHARMACOTHER, V109, P2472, DOI 10.1016/j.biopha.2018.11.120
   Kahn SE, 2006, NATURE, V444, P840, DOI 10.1038/nature05482
   Kitamura H, 2013, ADIPOCYTE, V2, P227, DOI 10.4161/adip.25608
   Koya-Miyata S, 2009, BIOL PHARM BULL, V32, P2022, DOI 10.1248/bpb.32.2022
   Krajmalnik-Brown R, 2012, NUTR CLIN PRACT, V27, P201, DOI 10.1177/0884533611436116
   Kumazawa S, 2014, ASIAN PAC J TROP MED, V7, P16, DOI 10.1016/S1995-7645(13)60184-4
   Langmead B, 2012, NAT METHODS, V9, P357, DOI [10.1038/NMETH.1923, 10.1038/nmeth.1923]
   Lapa C, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-17148-w
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Li HZ, 2020, FRONT MICROBIOL, V11, DOI 10.3389/fmicb.2020.00512
   Li YJ, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/981896
   Liu J, 2011, HEAD NECK-J SCI SPEC, V33, P1774, DOI 10.1002/hed.21701
   Lizcano F, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20205058
   Lynch CJ, 2014, NAT REV ENDOCRINOL, V10, P723, DOI 10.1038/nrendo.2014.171
   Ma LY, 2020, GUT MICROBES, V12, DOI 10.1080/19490976.2020.1832857
   Moller DE, 2000, TRENDS ENDOCRIN MET, V11, P212, DOI 10.1016/S1043-2760(00)00272-1
   Ouchi N, 2010, SCIENCE, V329, P454, DOI 10.1126/science.1188280
   Parnell JA, 2012, GUT MICROBES, V3, P29, DOI 10.4161/gmic.19246
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rehman K, 2016, J BIOMED SCI, V23, DOI 10.1186/s12929-016-0303-y
   Roberts-Toler C, 2015, OBESITY, V23, P1765, DOI 10.1002/oby.21134
   Roquetto AR, 2015, FOOD RES INT, V76, P796, DOI 10.1016/j.foodres.2015.07.026
   Rosen ED, 2006, NAT REV MOL CELL BIO, V7, P885, DOI 10.1038/nrm2066
   Saito M, 2014, ENDOCR J, V61, P409, DOI 10.1507/endocrj.EJ13-0527
   Sakai T, 2017, BIOL PHARM BULL, V40, P391, DOI 10.1248/bpb.b16-00577
   Shahinozzaman M, 2018, MOLECULES, V23, DOI 10.3390/molecules23102479
   Shimizu I, 2015, CURR OBES REP, V4, P224, DOI 10.1007/s13679-015-0157-8
   Sonnenburg JL, 2016, NATURE, V535, P56, DOI 10.1038/nature18846
   Su KY, 2014, J AGR FOOD CHEM, V62, P3192, DOI 10.1021/jf500096c
   Tol MJ, 2016, DIABETES, V65, P2591, DOI 10.2337/db16-0243
   Tsuda T, 2021, J AGR FOOD CHEM, V69, P15484, DOI 10.1021/acs.jafc.1c06194
   Turnbaugh PJ, 2008, CELL HOST MICROBE, V3, P213, DOI 10.1016/j.chom.2008.02.015
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Vishvanath L, 2019, J CLIN INVEST, V129, P4022, DOI 10.1172/JCI129191
   Wu Y, 2008, AM J PHYSIOL-ENDOC M, V295, pE205, DOI 10.1152/ajpendo.90316.2008
NR 68
TC 13
Z9 13
U1 2
U2 33
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD APR
PY 2023
VL 160
AR 114386
DI 10.1016/j.biopha.2023.114386
EA FEB 2023
PG 14
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 9Q8CE
UT WOS:000945184500001
PM 36773526
OA gold
DA 2025-06-11
ER

PT J
AU Devrajani, T
   Abid, S
   Shaikh, H
   Shaikh, I
   Devrajani, DB
   Memon, SM
   Waryah, AM
   Ujjan, ID
   Syed, BM
AF Devrajani, Tarachand
   Abid, Shariq
   Shaikh, Hina
   Shaikh, Iram
   Devrajani, Durshana Bai
   Memon, Sikander Munir
   Waryah, Ali Muhammad
   Ujjan, Ikram Din
   Syed, Binafsha Manzoor
TI Relationship between aging and control of metabolic syndrome with
   telomere shortening: a cross-sectional study
SO SCIENTIFIC REPORTS
LA English
DT Article
ID NUTRITION EXAMINATION SURVEY; SOCIOECONOMIC-STATUS; NATIONAL-HEALTH;
   LENGTH; ASSOCIATION; MORTALITY; P73
AB Aging is considered one of the major risk factors for several human disorders. The telomere plays a crucial role in regulating cellular responsiveness to stress and growth stimuli as well as maintaining the integrity of the Deoxyribonucleic Acid (DNA), and aging leads to the progressive decline in the telomere length (TL) due to continuous cell division. The aim of this study was to determine the relationship between TL and advancing age and the impact of metabolic syndrome (MetS) on TL. Firstly, we determined the association of advancing age and TL, by measuring telomere length (T/S ratio) in healthy volunteers (n = 90). The TL was compared between normal population and patients with metabolic syndrome (n = 298). The age matched controlled and uncontrolled MetS patients (n = 149) were also compared for their TL T/S ratio. The TL showed negative correlation with advancing age, whereas the significant change was observed at the cut-offs of 40 and 70 years defining 40 with longer TL and 70 as shorter TL. The longest T/S ratio at 2.46 was measured at the age range of 1 year in healthy volunteers, while elderly population showed considerably shorter TL. The patients older than 60 years with poor or uncontrolled MetS had shorter TL, as compared to the controlled MetS. In conclusion our findings suggest that TL was negatively correlated with advancing age. Uncontrolled metabolic syndrome appeared to have worsening effects on TL. Telomere length appears to have potential to be used a parameter to determine age. However, further large scale studies are recommended to make firm guidelines.
C1 [Devrajani, Tarachand; Abid, Shariq; Memon, Sikander Munir; Syed, Binafsha Manzoor] Liaquat Univ Med & Hlth Sci, Med Res Ctr, Clin Res Div, Jamshoro, Pakistan.
   [Devrajani, Tarachand] Liaquat Univ Med & Hlth Sci, Dept Med, Jamshoro, Pakistan.
   [Shaikh, Hina; Shaikh, Iram; Devrajani, Durshana Bai; Waryah, Ali Muhammad] Liaquat Univ Med & Hlth Sci, Med Res Ctr, Dept Mol Biol & Genet, Jamshoro, Pakistan.
   [Ujjan, Ikram Din] Liaquat Univ Med & Hlth Sci, Dept Pathol, Jamshoro, Pakistan.
C3 Liaquat University of Medical & Health Sciences; Liaquat University of
   Medical & Health Sciences; Liaquat University of Medical & Health
   Sciences; Liaquat University of Medical & Health Sciences
RP Syed, BM (corresponding author), Liaquat Univ Med & Hlth Sci, Med Res Ctr, Clin Res Div, Jamshoro, Pakistan.
EM binafsha.syed@lumhs.edu.pk
RI Syed, Binafsha/AAC-6670-2020; Waryah, Ali/A-5003-2018; Memon,
   Sikander/N-6764-2016
OI Memon, Sikander/0000-0001-9682-3527
FU Staff of Medical Research Center, laboratory of Molecular Biology and
   Genetics for providing experimentation support and platform; and Vice
   Chancellor office for administrative support.
FX Staff of Medical Research Center, laboratory of Molecular Biology and
   Genetics for providing experimentation support and platform; and Vice
   Chancellor office for administrative support.
CR Fares DA, 2020, BIRTH DEFECTS RES, V112, P645, DOI 10.1002/bdr2.1682
   Benetti R, 2007, NAT GENET, V39, P243, DOI 10.1038/ng1952
   Bonomini F, 2011, HISTOCHEM CELL BIOL, V135, P571, DOI 10.1007/s00418-011-0815-1
   Bonomini F, 2015, AGING DIS, V6, P109, DOI 10.14336/AD.2014.0305
   Bowen RL, 2004, GERONTOLOGY, V50, P265, DOI 10.1159/000079125
   Brouilette S, 2003, ARTERIOSCL THROM VAS, V23, P842, DOI 10.1161/01.ATV.0000067426.96344.32
   Calado RT, 2013, SEMIN HEMATOL, V50, P165, DOI 10.1053/j.seminhematol.2013.03.030
   Cawthon RM, 2003, LANCET, V361, P393, DOI 10.1016/S0140-6736(03)12384-7
   Cawthon RM, 2002, NUCLEIC ACIDS RES, V30, DOI 10.1093/nar/30.10.e47
   Cherkas LF, 2008, ARCH INTERN MED, V168, P154, DOI 10.1001/archinternmed.2007.39
   Dillin A, 2014, CURR OPIN CELL BIOL, V26, P107, DOI 10.1016/j.ceb.2013.12.003
   Factor-Litvak P, 2016, PEDIATRICS, V137, DOI 10.1542/peds.2015-3927
   Farzaneh-Far R, 2008, ARTERIOSCL THROM VAS, V28, P1379, DOI 10.1161/ATVBAHA.108.167049
   Gavia-García G, 2021, BIOLOGY-BASEL, V10, DOI 10.3390/biology10040253
   Gong JG, 1999, NATURE, V399, P806
   Huang Y, 2019, PSYCHONEUROENDOCRINO, V103, P180, DOI 10.1016/j.psyneuen.2019.01.015
   Kong CM, 2013, FEBS J, V280, P3180, DOI 10.1111/febs.12326
   Lin J, 2010, J IMMUNOL METHODS, V352, P71, DOI 10.1016/j.jim.2009.09.012
   Morley JE, 2004, J GERONTOL A-BIOL, V59, P139
   Nawrot TS, 2004, LANCET, V363, P507, DOI 10.1016/S0140-6736(04)15535-9
   Needham BL, 2015, EPIDEMIOLOGY, V26, P528, DOI 10.1097/EDE.0000000000000299
   Needham BL, 2013, SOC SCI MED, V85, P1, DOI 10.1016/j.socscimed.2013.02.023
   Okuda K, 2002, PEDIATR RES, V52, P377, DOI 10.1203/01.PDR.0000022341.72856.72
   Passos JF, 2007, NUCLEIC ACIDS RES, V35, P7505, DOI 10.1093/nar/gkm893
   Révész D, 2014, J CLIN ENDOCR METAB, V99, P4607, DOI 10.1210/jc.2014-1851
   Saint-Leandre B, 2020, TRENDS GENET, V36, P232, DOI 10.1016/j.tig.2020.01.007
   Steinert S, 2004, MOL CELL BIOL, V24, P4571, DOI 10.1128/MCB.24.10.4571-4580.2004
   Stiewe T, 2001, APOPTOSIS, V6, P447, DOI 10.1023/A:1012433522902
   Svenson U, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0021485
   Valdes AM, 2005, LANCET, V366, P662, DOI 10.1016/S0140-6736(05)66630-5
   Yang ZW, 2009, HYPERTENSION, V53, P639, DOI 10.1161/HYPERTENSIONAHA.108.123752
NR 31
TC 7
Z9 7
U1 0
U2 1
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD OCT 19
PY 2023
VL 13
IS 1
AR 17878
DI 10.1038/s41598-023-44715-1
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA U7SK9
UT WOS:001086765500027
PM 37857729
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Iacob, SA
   Iacob, DG
AF Iacob, Simona Alexandra
   Iacob, Diana Gabriela
TI Non-Alcoholic Fatty Liver Disease in HIV/HBV Patients - a Metabolic
   Imbalance Aggravated by Antiretroviral Therapy and Perpetuated by the
   Hepatokine/Adipokine Axis Breakdown
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE non-alcoholic fatty liver disease; hepatitis B virus; HIV; hepatokines;
   adipokines; oxidative stress; metabolic syndrome; antiretroviral
   treatment
ID GROWTH-FACTOR 21; NF-KAPPA-B; CHRONIC HEPATITIS-B; VIRUS-INFECTED
   PATIENTS; MESSENGER-RNA EXPRESSION; MORBIDLY OBESE-PATIENTS; SERUM
   ADIPOKINE LEVELS; INSULIN-RESISTANCE; FETUIN-A; HEPATOCELLULAR-CARCINOMA
AB Non-alcoholic fatty liver disease (NAFLD) is strongly associated with the metabolic syndrome and is one of the most prevalent comorbidities in HIV and HBV infected patients. HIV plays an early and direct role in the development of metabolic syndrome by disrupting the mechanism of adipogenesis and synthesis of adipokines. Adipokines, molecules that regulate the lipid metabolism, also contribute to the progression of NAFLD either directly or via hepatic organokines (hepatokines). Most hepatokines play a direct role in lipid homeostasis and liver inflammation but their role in the evolution of NAFLD is not well defined. The role of HBV in the pathogenesis of NAFLD is controversial. HBV has been previously associated with a decreased level of triglycerides and with a protective role against the development of steatosis and metabolic syndrome. At the same time HBV displays a high fibrogenetic and oncogenetic potential. In the HIV/HBV co-infection, the metabolic changes are initiated by mitochondrial dysfunction as well as by the fatty overload of the liver, two interconnected mechanisms. The evolution of NAFLD is further perpetuated by the inflammatory response to these viral agents and by the variable toxicity of the antiretroviral therapy. The current article discusses the pathogenic changes and the contribution of the hepatokine/adipokine axis in the development of NAFLD as well as the implications of HIV and HBV infection in the breakdown of the hepatokine/adipokine axis and NAFLD progression.
C1 [Iacob, Simona Alexandra; Iacob, Diana Gabriela] Carol Davila Univ Med & Pharm, Dept Infect Dis, Bucharest, Romania.
   [Iacob, Simona Alexandra] Natl Inst Infect Dis Prof Dr Matei Bals, Dept Infect Dis, Bucharest, Romania.
   [Iacob, Diana Gabriela] Emergency Univ Hosp, Dept Infect Dis, Bucharest, Romania.
C3 Carol Davila University of Medicine & Pharmacy; National Institute for
   Infectious Diseases "Matei Bals"; National Institute for Infectious
   Diseases "Matei Bals"; National Institute for Infectious Diseases "Matei
   Bals"
RP Iacob, DG (corresponding author), Carol Davila Univ Med & Pharm, Dept Infect Dis, Bucharest, Romania.; Iacob, DG (corresponding author), Emergency Univ Hosp, Dept Infect Dis, Bucharest, Romania.
EM dianagiacob@gmail.com
RI iacob, simona/ABF-7087-2020; Iacob, Diana/ABB-8424-2020
CR Abenavoli L, 2014, PANMINERVA MED, V56, P189
   Addy CL, 2003, J CLIN ENDOCR METAB, V88, P627, DOI 10.1210/jc.2002-020795
   Akbal E, 2012, J CLIN LAB ANAL, V26, P115, DOI 10.1002/jcla.21491
   Aller R, 2009, DIGEST DIS SCI, V54, P1772, DOI 10.1007/s10620-008-0539-9
   Amponsah-Dacosta Edina, 2020, World J Virol, V9, P54, DOI 10.5501/wjv.v9.i5.54
   Asrih M, 2016, CELL PHYSIOL BIOCHEM, V38, P1218, DOI 10.1159/000443070
   Ataseven H, 2006, MEDIAT INFLAMM, V2006, DOI 10.1155/MI/2006/78380
   Avettand-Fènoël V, 2016, CLIN MICROBIOL REV, V29, P859, DOI 10.1128/CMR.00015-16
   Awazawa M, 2009, BIOCHEM BIOPH RES CO, V382, P51, DOI 10.1016/j.bbrc.2009.02.131
   Baffy G, 2009, J HEPATOL, V51, P212, DOI 10.1016/j.jhep.2009.03.008
   Bakasis AD, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10051212
   Bar-Yishay I, 2011, LIVER INT, V31, P282, DOI 10.1111/j.1478-3231.2010.02423.x
   Baum MK, 1997, J ACQ IMMUN DEF SYND, V15, P370, DOI 10.1097/00042560-199708150-00007
   Becker SA, 1998, J VIROL, V72, P266, DOI 10.1128/JVI.72.1.266-272.1998
   Bekaert M, 2016, OBES REV, V17, P68, DOI 10.1111/obr.12333
   Benedini S, 2016, J TRANSL INTERN MED, V4, P150, DOI 10.1515/jtim-2016-0026
   Berg AH, 2001, NAT MED, V7, P947, DOI 10.1038/90992
   Berti L, 2015, MOL METAB, V4, P519, DOI 10.1016/j.molmet.2015.04.002
   Bertolani C, 2006, AM J PATHOL, V169, P2042, DOI 10.2353/ajpath.2006.060081
   Bischoff J, 2021, ECLINICALMEDICINE, V40, DOI 10.1016/j.eclinm.2021.101116
   Boothby M, 2009, ANTIVIR THER, V14, P1089, DOI 10.3851/IMP1457
   Boutari C, 2018, ENDOCRINOL METAB, V33, P33, DOI 10.3803/EnM.2018.33.1.33
   Bozaoglu K, 2007, ENDOCRINOLOGY, V148, P4687, DOI 10.1210/en.2007-0175
   Buechler C., 2014, Endocrinol. Metab. Synd, V3, P1, DOI DOI 10.4172/2161-1017.1000144
   Buzzetti E, 2016, METABOLISM, V65, P1038, DOI 10.1016/j.metabol.2015.12.012
   Calvo M, 2014, CURR OPIN HIV AIDS, V9, P332, DOI 10.1097/COH.0000000000000075
   Campa A, 1999, J ACQ IMMUN DEF SYND, V20, P508, DOI 10.1097/00042560-199904150-00015
   CAO YZ, 1992, AIDS, V6, P65, DOI 10.1097/00002030-199201000-00008
   Carr A, 1999, LANCET, V353, P2093, DOI 10.1016/S0140-6736(98)08468-2
   Carr A, 2004, LANCET, V363, P429, DOI 10.1016/S0140-6736(04)15489-5
   Caviglia GP, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21228838
   Chen DL, 2002, J CLIN ENDOCR METAB, V87, P4845, DOI 10.1210/jc.2002-020794
   Chen H., 2020, Liver Research, V4, P15, DOI [10.1016/j.livres.2020.02.004, DOI 10.1016/J.LIVRES.2020.02.004]
   Chen Y, 2021, J CELL PHYSIOL, V236, P3800, DOI 10.1002/jcp.30121
   Cheng J, 2015, BIOCHEM BIOPH RES CO, V458, P140, DOI 10.1016/j.bbrc.2015.01.083
   Cheng ZM, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.713981
   Chiang CH, 2013, INT J OBESITY, V37, P410, DOI 10.1038/ijo.2012.63
   Chiang CH, 2013, OBESITY, V21, P291, DOI 10.1002/oby.20000
   Cho CS, 2020, GENES-BASEL, V11, DOI 10.3390/genes11080896
   Chopin LK, 2012, ENDOCR REV, V33, P849, DOI 10.1210/er.2011-1007
   Chrusciel P, 2016, ATHEROSCLEROSIS, V253, P194, DOI 10.1016/j.atherosclerosis.2016.07.897
   Cohen G, 2011, DIABETES, V60, P2830, DOI 10.2337/db11-0347
   Colin JF, 1999, HEPATOLOGY, V29, P1306, DOI 10.1002/hep.510290447
   Costandi J, 2011, CIRC RES, V108, P727, DOI 10.1161/CIRCRESAHA.110.238949
   Cotter TG, 2020, GASTROENTEROLOGY, V158, P1851, DOI 10.1053/j.gastro.2020.01.052
   Curat CA, 2006, DIABETOLOGIA, V49, P744, DOI 10.1007/s00125-006-0173-z
   Czaja MJ, 2010, TRENDS ENDOCRIN MET, V21, P707, DOI 10.1016/j.tem.2010.08.010
   Dai XH, 2011, INT J MOL SCI, V12, P3846, DOI 10.3390/ijms12063846
   Damouche A, 2015, PLOS PATHOG, V11, DOI 10.1371/journal.ppat.1005153
   Dasgupta S, 2010, BIOCHEM J, V429, P451, DOI 10.1042/BJ20100330
   de Boer JF, 2009, AM J PHYSIOL-GASTR L, V296, pG196, DOI 10.1152/ajpgi.00029.2008
   dos Santos ARD, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22052639
   de Waal R, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0063623
   Delhanty PJD, 2011, PEPTIDES, V32, P2309, DOI 10.1016/j.peptides.2011.03.001
   Döcke S, 2013, EUR J ENDOCRINOL, V169, P547, DOI 10.1530/EJE-13-0112
   Dogru T, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22126627
   Domingo P, 2010, AIDS, V24, P2629, DOI 10.1097/QAD.0b013e3283400088
   Dröge W, 2002, PHYSIOL REV, V82, P47, DOI 10.1152/physrev.00018.2001
   Duro M, 2018, INT J STD AIDS, V29, P1089, DOI 10.1177/0956462418775188
   Dutchak PA, 2012, CELL, V148, P556, DOI 10.1016/j.cell.2011.11.062
   Duvnjak M, 2009, WORLD J GASTROENTERO, V15, P6023, DOI 10.3748/wjg.15.6023
   DWORKIN BM, 1994, CHEM-BIOL INTERACT, V91, P181, DOI 10.1016/0009-2797(94)90038-8
   Dziegielewska KM, 1998, IMMUNOL LETT, V60, P31, DOI 10.1016/S0165-2478(97)00126-0
   Eckard AR, 2020, JAIDS-J ACQ IMM DEF, V83, pE30, DOI 10.1097/QAI.0000000000002285
   Emanuelli B, 2014, J CLIN INVEST, V124, P515, DOI 10.1172/JCI67353
   Falasca K, 2006, ANN CLIN LAB SCI, V36, P59
   Ferreira DF, 2015, BBA-MOL CELL BIOL L, V1851, P1353, DOI 10.1016/j.bbalip.2015.07.002
   Filippatos TD, 2008, EUR J CLIN INVEST, V38, P71, DOI 10.1111/j.1365-2362.2007.01904.x
   Finkelstein JL, 2015, J INT AIDS SOC, V18, DOI 10.7448/IAS.18.1.19033
   Fisher FM, 2016, ANNU REV PHYSIOL, V78, P223, DOI 10.1146/annurev-physiol-021115-105339
   Freitas P, 2014, BMC INFECT DIS, V14, DOI 10.1186/1471-2334-14-347
   Frühbeck G, 2006, BIOCHEM J, V393, P7, DOI 10.1042/BJ20051578
   Gälman C, 2008, CELL METAB, V8, P169, DOI 10.1016/j.cmet.2008.06.014
   Gamberi T, 2018, BIOMEDICINES, V6, DOI 10.3390/biomedicines6020052
   Garrigue I, 2000, AIDS, V14, P2851, DOI 10.1097/00002030-200012220-00006
   Gaul S, 2021, J HEPATOL, V74, P156, DOI 10.1016/j.jhep.2020.07.041
   Ge LP, 2014, INT J NANOMED, V9, P2399, DOI 10.2147/IJN.S55015
   Gelpi M, 2019, BMC INFECT DIS, V19, DOI 10.1186/s12879-019-4347-y
   Genc H, 2013, ANN HEPATOL, V12, P380, DOI 10.1016/S1665-2681(19)31338-9
   Giby VG, 2014, WORLD J HEPATOL, V6, P570, DOI 10.4254/wjh.v6.i8.570
   Gladyshev VN, 1999, P NATL ACAD SCI USA, V96, P835, DOI 10.1073/pnas.96.3.835
   Goralski KB, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20194778
   Gruevska A, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10020410
   Guaraldi G, 2008, CLIN INFECT DIS, V47, P250, DOI 10.1086/589294
   Gürtler LG, 2014, INTERVIROLOGY, V57, P212, DOI 10.1159/000360942
   Guillin OM, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092101
   Haberl EM, 2020, CANCERS, V12, DOI 10.3390/cancers12102967
   Hamaguchi M, 2005, ANN INTERN MED, V143, P722, DOI 10.7326/0003-4819-143-10-200511150-00009
   Han DL, 2021, J CLIN TRANSL HEPATO, V9, P484, DOI 10.14218/JCTH.2021.00018
   Han JB, 2018, PROTEIN CELL, V9, P145, DOI 10.1007/s13238-017-0409-3
   Hassan K, 2014, WORLD J GASTROENTERO, V20, P12082, DOI 10.3748/wjg.v20.i34.12082
   Haubrich RH, 2009, AIDS, V23, P1109, DOI 10.1097/QAD.0b013e32832b4377
   Haukeland JW, 2012, EUR J ENDOCRINOL, V166, P503, DOI 10.1530/EJE-11-0864
   Helfer G, 2018, J ENDOCRINOL, V238, pR79, DOI 10.1530/JOE-18-0174
   Hennige AM, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001765
   Heo YJ, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/4021623
   Her ZS, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.580968
   Holland WL, 2013, CELL METAB, V17, P790, DOI 10.1016/j.cmet.2013.03.019
   Hong MZ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0087344
   Horn P, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-27543-6
   Hsieh PS, 2011, WORLD J GASTROENTERO, V17, P5240, DOI 10.3748/wjg.v17.i48.5240
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Huang X, 2016, J ENDOCRINOL INVEST, V39, P607, DOI 10.1007/s40618-015-0408-2
   Hui CK, 2007, J HEPATOL, V47, P191, DOI 10.1016/j.jhep.2007.02.023
   Ikejima K, 2001, HEPATOLOGY, V34, P288, DOI 10.1053/jhep.2001.26518
   Iroz A, 2017, CELL REP, V21, P403, DOI 10.1016/j.celrep.2017.09.065
   Iser DM, 2011, AIDS, V25, P197, DOI 10.1097/QAD.0b013e3283410ccb
   Ishtiaq SM, 2019, REV ENDOCR METAB DIS, V20, P253, DOI 10.1007/s11154-019-09510-2
   Ismaiel A, 2021, J CLIN MED, V10, DOI 10.3390/jcm10143029
   Urraza-Robledo AI, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0252144
   Jaeschke H, 2011, J GASTROEN HEPATOL, V26, P173, DOI 10.1111/j.1440-1746.2010.06592.x
   Jang JC, 2017, P NATL ACAD SCI USA, V114, pE10399, DOI 10.1073/pnas.1716015114
   Jarcuska P, 2016, WORLD J GASTROENTERO, V22, P155, DOI 10.3748/wjg.v22.i1.155
   Jensen-Cody SO, 2021, MOL METAB, V44, DOI 10.1016/j.molmet.2020.101138
   Jeong WI, 2006, HEPATOLOGY, V44, P1441, DOI 10.1002/hep.21419
   Jiang LL, 2009, EUR J GASTROEN HEPAT, V21, P662, DOI 10.1097/MEG.0b013e328317f4b5
   Johannsen K, 2019, HORM METAB RES, V51, P602, DOI 10.1055/a-0897-8565
   Johnson AA, 2001, J BIOL CHEM, V276, P40847, DOI 10.1074/jbc.M106743200
   Jurkowska K, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10102739
   Kadowaki T, 2005, ENDOCR REV, V26, P439, DOI 10.1210/er.2005-0005
   Kakuma T, 2000, P NATL ACAD SCI USA, V97, P8536, DOI 10.1073/pnas.97.15.8536
   Kamin D, 2005, J CLIN ENDOCR METAB, V90, P3423, DOI 10.1210/jc.2005-0287
   Kawano Y, 2013, J GASTROENTEROL, V48, P434, DOI 10.1007/s00535-013-0758-5
   Keinicke H, 2020, ENDOCR CONNECT, V9, P755, DOI 10.1530/EC-20-0152
   Khalili M, 2021, CLIN INFECT DIS, V73, pE3275, DOI 10.1093/cid/ciaa1303
   Khalili M, 2021, AM J GASTROENTEROL, V116, P1686, DOI 10.14309/ajg.0000000000001257
   Khodarev NN, 2012, CLIN CANCER RES, V18, P3015, DOI 10.1158/1078-0432.CCR-11-3225
   Kim KH, 2007, GASTROENTEROLOGY, V132, P1955, DOI 10.1053/j.gastro.2007.03.039
   Kim RJ, 2006, OBESITY, V14, P994, DOI 10.1038/oby.2006.114
   Klein MB, 2016, CLIN INFECT DIS, V63, P1160, DOI 10.1093/cid/ciw531
   Kleiner DE, 2019, JAMA NETW OPEN, V2, DOI 10.1001/jamanetworkopen.2019.12565
   Knight ZA, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011376
   Kosmiski L, 2003, ANTIVIR THER, V8, P9
   Koutkia P, 2004, AM J PHYSIOL-ENDOC M, V286, pE296, DOI 10.1152/ajpendo.00335.2003
   Kovocic JC, 2005, ANTIVIR THER, V10, P135
   Kucukoglu O, 2021, J HEPATOL, V74, P442, DOI 10.1016/j.jhep.2020.10.030
   Kukla M, 2010, POL J PATHOL, V61, P147
   Kukla M, 2010, SCAND J GASTROENTERO, V45, P235, DOI 10.3109/00365520903443852
   Kumar P, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0110405
   Lagathu C, 2004, ANTIVIR THER, V9, P911
   Lagathu C, 2007, ANTIVIR THER, V12, P489
   Lebensztejn DM, 2016, ACTA BIOCHIM POL, V63, P459, DOI 10.18388/abp.2015_1252
   Lee JH, 2006, J CLIN ENDOCR METAB, V91, P2605, DOI 10.1210/jc.2005-1545
   Lee KJ, 2018, GUT LIVER, V12, P449, DOI 10.5009/gnl17443
   Lee Y, 2001, J BIOL CHEM, V276, P5629, DOI 10.1074/jbc.M008553200
   Lehrke M, 2009, EUR J ENDOCRINOL, V161, P339, DOI 10.1530/EJE-09-0380
   Li HT, 2013, J HEPATOL, V58, P557, DOI 10.1016/j.jhep.2012.10.029
   Li HT, 2010, J HEPATOL, V53, P934, DOI 10.1016/j.jhep.2010.05.018
   Li JJ, 2018, BRIT J CANCER, V118, P1337, DOI 10.1038/s41416-018-0077-y
   Li L, 2016, CLIN CHEM LAB MED, V54, P693, DOI 10.1515/cclm-2015-0307
   Li YR, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.699807
   Li YW, 2016, WORLD J GASTROENTERO, V22, P1943, DOI 10.3748/wjg.v22.i6.1943
   Li ZB, 2018, CYTOKINE, V108, P145, DOI 10.1016/j.cyto.2018.03.023
   Li ZR, 2014, P NATL ACAD SCI USA, V111, P13163, DOI 10.1073/pnas.1411571111
   Liang NL, 2015, MOL MED REP, V11, P1073, DOI 10.3892/mmr.2014.2795
   Lin CW, 2015, DIGEST DIS SCI, V60, P3513, DOI 10.1007/s10620-015-3772-z
   Lin W, 2021, DIABET METAB SYND OB, V14, P3281, DOI 10.2147/DMSO.S317096
   Lin WY, 2011, J BIOL CHEM, V286, P2665, DOI 10.1074/jbc.M110.168286
   Lin ZF, 2013, CELL METAB, V17, P779, DOI 10.1016/j.cmet.2013.04.005
   Linden AG, 2018, J LIPID RES, V59, P475, DOI 10.1194/jlr.M081836
   Liu CJ, 2009, HEPATOL INT, V3, P364, DOI 10.1007/s12072-008-9111-0
   Liu J, 2015, METABOLISM, V64, P380, DOI 10.1016/j.metabol.2014.11.009
   Liu SS, 2021, J CLIN TRANSL HEPATO, V9, P3, DOI 10.14218/JCTH.2020.00081
   Liu T, 2017, SIGNAL TRANSDUCT TAR, V2, DOI 10.1038/sigtrans.2017.23
   Liu YL, 2016, SCI REP-UK, V6, DOI 10.1038/srep31026
   Lonardo A, 2015, DIGEST LIVER DIS, V47, P181, DOI 10.1016/j.dld.2014.09.020
   Luedde T, 2011, NAT REV GASTRO HEPAT, V8, P108, DOI 10.1038/nrgastro.2010.213
   Luo YD, 2017, CYTOKINE GROWTH F R, V38, P59, DOI 10.1016/j.cytogfr.2017.08.001
   Machado MV, 2012, EUR J GASTROEN HEPAT, V24, P1166, DOI 10.1097/MEG.0b013e32835609b0
   Machado MV, 2011, J GASTROEN HEPATOL, V26, P1361, DOI 10.1111/j.1440-1746.2011.06801.x
   Majeed Y, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-87759-x
   Malagnino V, 2021, MICROORGANISMS, V9, DOI 10.3390/microorganisms9020396
   Manolakopoulos S, 2007, BMC GASTROENTEROL, V7, DOI 10.1186/1471-230X-7-17
   Fernández-Real JM, 2011, DIABETES, V60, P2179, DOI 10.2337/db10-1210
   Mao YQ, 2015, INT J MOL SCI, V16, P21911, DOI 10.3390/ijms160921911
   Mao YQ, 2015, CELL PHYSIOL BIOCHEM, V37, P563, DOI 10.1159/000430377
   Maponga TG, 2018, BMC INFECT DIS, V18, DOI 10.1186/s12879-018-3115-8
   Marchesini G, 2003, J CLIN ENDOCR METAB, V88, P5674, DOI 10.1210/jc.2003-031094
   Margolis AM, 2014, J MED TOXICOL, V10, P26, DOI 10.1007/s13181-013-0325-8
   Mariani S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113506
   Marques V, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.683250
   Mårtensson UEA, 2006, VIROLOGY, V355, P6, DOI 10.1016/j.virol.2006.07.010
   Martínez-Uña M, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21249368
   Maurice JB, 2017, AIDS, V31, P1621, DOI 10.1097/QAD.0000000000001504
   Maya-Monteiro CM, 2008, CELL CYCLE, V7, P1713, DOI 10.4161/cc.7.12.6157
   McPherson S, 2015, J HEPATOL, V62, P1148, DOI 10.1016/j.jhep.2014.11.034
   Meng ZJ, 2017, BMC GASTROENTEROL, V17, DOI 10.1186/s12876-016-0558-5
   Minard AY, 2016, CELL REP, V17, P29, DOI 10.1016/j.celrep.2016.08.086
   Misu H, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034952
   Miura K, 2014, WORLD J GASTROENTERO, V20, P7381, DOI 10.3748/wjg.v20.i23.7381
   Miyazaki T, 2005, BIOCHEM BIOPH RES CO, V333, P79, DOI 10.1016/j.bbrc.2005.05.076
   Morita M, 2012, FREE RADICAL RES, V46, P758, DOI 10.3109/10715762.2012.677840
   Moslehi A, 2018, J CLIN TRANSL HEPATO, V6, P332, DOI 10.14218/JCTH.2017.00061
   Mosoian A, 2017, J LEUKOCYTE BIOL, V101, P1083, DOI 10.1189/jlb.3HI0516-242R
   Muise ES, 2008, MOL PHARMACOL, V74, P403, DOI 10.1124/mol.108.044826
   Mulligan K, 2007, AIDS, V21, P47, DOI 10.1097/QAD.0b013e328011220e
   Mulligan K, 2009, J CLIN ENDOCR METAB, V94, P1137, DOI 10.1210/jc.2008-1588
   Musso G, 2005, AM J GASTROENTEROL, V100, P2438, DOI 10.1111/j.1572-0241.2005.00297.x
   Nagy GS, 2003, CLIN INFECT DIS, V36, P795, DOI 10.1086/367859
   Nassir F, 2016, WORLD J GASTROENTERO, V22, P10084, DOI 10.3748/wjg.v22.i46.10084
   Ninomiya S, 2011, CANCER PREV RES, V4, P2092, DOI 10.1158/1940-6207.CAPR-11-0340
   Nolan D, 2003, AIDS, V17, P1329, DOI 10.1097/00002030-200306130-00007
   Ogawa Y, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0065211
   Opoku YK, 2020, EXCLI J, V19, P567, DOI 10.17179/excli2020-1287
   Otero M, 2006, RHEUMATOLOGY, V45, P944, DOI 10.1093/rheumatology/kel157
   Pal D, 2012, NAT MED, V18, P1279, DOI 10.1038/nm.2851
   Palhinha L, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00841
   Palios J, 2012, EXP DIABETES RES, DOI 10.1155/2012/103063
   Parvez MK, 2015, WORLD J HEPATOL, V7, P121, DOI 10.4254/wjh.v7.i1.121
   Pérez-Matute P, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/493413
   Perumpail BJ, 2017, WORLD J GASTROENTERO, V23, P8263, DOI 10.3748/wjg.v23.i47.8263
   Peter A, 2018, AM J PHYSIOL-ENDOC M, V314, pE266, DOI 10.1152/ajpendo.00262.2017
   Pinti M, 2006, BBA-BIOENERGETICS, V1757, P700, DOI 10.1016/j.bbabio.2006.05.001
   Pinzone MR, 2013, CURR DRUG TARGETS, V14, P648, DOI 10.2174/1389450111314060005
   Pohl R, 2017, EUR J CLIN INVEST, V47, P7, DOI 10.1111/eci.12695
   Poli G, 1997, FREE RADICAL BIO MED, V22, P287, DOI 10.1016/S0891-5849(96)00327-9
   Polyzos SA, 2020, HORM-INT J ENDOCRINO, V19, P61, DOI 10.1007/s42000-019-00127-3
   Polyzos SA, 2016, METABOLISM, V65, P1297, DOI 10.1016/j.metabol.2016.05.013
   Polyzos SA, 2016, METABOLISM, V65, P1062, DOI 10.1016/j.metabol.2015.11.006
   Polyzos SA, 2016, DIABETOLOGIA, V59, P30, DOI 10.1007/s00125-015-3769-3
   Polyzos SA, 2014, ANN HEPATOL, V13, P150, DOI 10.1016/S1665-2681(19)30917-2
   Polyzos SA, 2011, METABOLISM, V60, P313, DOI 10.1016/j.metabol.2010.09.003
   Polyzos SA, 2011, J CLIN GASTROENTEROL, V45, P50, DOI 10.1097/MCG.0b013e3181ec5c66
   Previte DM, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0175549
   Proal A.D., 2021, Immunometabolism, V3, P210003
   Qiu Y, 2019, ANN NUTR METAB, V74, P44, DOI 10.1159/000495215
   Ranade K, 2008, AIDS, V22, P1561, DOI 10.1097/QAD.0b013e32830a9886
   Rastogi A, 2011, INDIAN J PATHOL MICR, V54, P454, DOI 10.4103/0377-4929.85074
   Reddy YK, 2020, J CLIN EXP HEPATOL, V10, P245, DOI 10.1016/j.jceh.2019.07.002
   Reeves MA, 2009, CELL MOL LIFE SCI, V66, P2457, DOI 10.1007/s00018-009-0032-4
   Reitman ML, 2012, CELL METAB, V16, P1, DOI 10.1016/j.cmet.2012.06.009
   Sanders FWB, 2016, BIOL REV, V91, P452, DOI 10.1111/brv.12178
   Sankalé JL, 2006, HIV MED, V7, P268, DOI 10.1111/j.1468-1293.2006.00372.x
   Sato M, 2015, LIVER INT, V35, P925, DOI 10.1111/liv.12478
   Saxena NK, 2007, CANCER RES, V67, P2497, DOI 10.1158/0008-5472.CAN-06-3075
   Saxena NK, 2015, TRENDS ENDOCRIN MET, V26, P153, DOI 10.1016/j.tem.2015.01.002
   Saxena NK, 2010, GASTROENTEROLOGY, V139, P1762, DOI 10.1053/j.gastro.2010.07.001
   Schaap FG, 2013, BIOCHIMIE, V95, P692, DOI 10.1016/j.biochi.2012.10.019
   Schindler K, 2006, EUR J CLIN INVEST, V36, P640, DOI 10.1111/j.1365-2362.2006.01699.x
   Seki E, 2007, NAT MED, V13, P1324, DOI 10.1038/nm1663
   Sell H, 2010, J CLIN ENDOCR METAB, V95, P2892, DOI 10.1210/jc.2009-2374
   Serviddio G, 2013, FREE RADICAL BIO MED, V65, P952, DOI 10.1016/j.freeradbiomed.2013.08.174
   Sharma D, 2010, HEPATOLOGY, V52, P1713, DOI 10.1002/hep.23892
   Shen C, 2014, BMC GASTROENTEROL, V14, DOI 10.1186/1471-230X-14-39
   Sheng CH, 2008, ENDOCRINE, V33, P135, DOI 10.1007/s12020-008-9065-y
   Shi JP, 2008, J GASTROEN HEPATOL, V23, P1419, DOI 10.1111/j.1440-1746.2008.05531.x
   Shi YX, 2016, WORLD J GASTROENTERO, V22, P8161, DOI 10.3748/wjg.v22.i36.8161
   Shimizu I, 2012, LIPID PEROXIDATION, P483, DOI 10.5772/46180
   Shu RZ, 2009, LAB INVEST, V89, P1043, DOI 10.1038/labinvest.2009.63
   Silswal N, 2005, BIOCHEM BIOPH RES CO, V334, P1092, DOI 10.1016/j.bbrc.2005.06.202
   Singh KP, 2017, AIDS, V31, P2035, DOI 10.1097/QAD.0000000000001574
   Sinha U., 2012, INDIAN J ENDOCRINOLO, V16, P637, DOI [10.4103/2230-8210.105583, DOI 10.4103/2230-8210.105583]
   SOMASUNDARAN M, 1994, J CELL BIOL, V126, P1353, DOI 10.1083/jcb.126.6.1353
   Spahis S, 2017, ANTIOXID REDOX SIGN, V26, P519, DOI 10.1089/ars.2016.6776
   Spirk M, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21207555
   Sterling RK, 2019, AM J GASTROENTEROL, V114, P746, DOI 10.1038/s41395-018-0409-9
   Sterling RK, 2013, J CLIN GASTROENTEROL, V47, P182, DOI 10.1097/MCG.0b013e318264181d
   Stern JH, 2016, CELL METAB, V23, P770, DOI 10.1016/j.cmet.2016.04.011
   Stojsavljevic S, 2014, WORLD J GASTROENTERO, V20, P18070, DOI 10.3748/wjg.v20.i48.18070
   Sulkowski MS, 2002, HEPATOLOGY, V35, P182, DOI 10.1053/jhep.2002.30319
   Sutinen J, 2003, ANTIVIR THER, V8, P199
   Tarkowski A, 2010, J CELL MOL MED, V14, P1419, DOI 10.1111/j.1582-4934.2009.00899.x
   Thio CL, 2009, HEPATOLOGY, V49, pS138, DOI 10.1002/hep.22883
   Tietge UJF, 2004, AM J PHYSIOL-ENDOC M, V287, pE82, DOI 10.1152/ajpendo.00494.2003
   Tillman EJ, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.601290
   Torretta S, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9020496
   Tripathi D, 2020, FEBS J, V287, P3141, DOI 10.1111/febs.15322
   Tsai IT, 2017, CYTOKINE, V90, P54, DOI 10.1016/j.cyto.2016.10.007
   Tsiodras S, 2006, AM J INFECT DIS, V2, P141, DOI 10.3844/ajidsp.2006.141.152
   Tsochatzis E, 2008, SCAND J GASTROENTERO, V43, P1128, DOI 10.1080/00365520802085387
   Unger RH, 2001, DIABETES, V50, pS118, DOI 10.2337/diabetes.50.2007.S118
   Unger RH, 2002, ANNU REV MED, V53, P319, DOI 10.1146/annurev.med.53.082901.104057
   Vernia S, 2014, CELL METAB, V20, P512, DOI 10.1016/j.cmet.2014.06.010
   Viard JP, 2004, AIDS, V18, P45, DOI 10.1097/00002030-200401020-00005
   Vlahakis SR, 2003, J INFECT DIS, V188, P1455, DOI 10.1086/379738
   Wandeler G, 2013, J INFECT DIS, V208, P1454, DOI 10.1093/infdis/jit351
   Wang BQ, 2019, MOL MED REP, V19, P320, DOI 10.3892/mmr.2018.9619
   Wang CC, 2015, J GASTROEN HEPATOL, V30, P14, DOI 10.1111/jgh.12700
   Wang CH, 2010, ATHEROSCLEROSIS, V211, P624, DOI 10.1016/j.atherosclerosis.2010.03.008
   Wang JX, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0236491
   Wang LF, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0464-z
   Wang N, 2017, PPAR RES, V2017, DOI 10.1155/2017/6561701
   Wang ZV, 2016, J MOL CELL BIOL, V8, P93, DOI 10.1093/jmcb/mjw011
   Wanninger J, 2012, MOL CELL ENDOCRINOL, V349, P248, DOI 10.1016/j.mce.2011.10.032
   Waris G, 2001, MOL CELL BIOL, V21, P7721, DOI 10.1128/MCB.21.22.7721-7730.2001
   Waseern T, 2008, SURGERY, V143, P334, DOI 10.1016/j.surg.2007.09.039
   Watt MJ, 2019, ENDOCR REV, V40, P1367, DOI 10.1210/er.2019-00034
   Wen FY, 2020, INT J ENDOCRINOL, V2020, DOI 10.1155/2020/9767926
   Wong GLH, 2009, GUT, V58, P111, DOI 10.1136/gut.2008.157735
   Wong VWS, 2006, CLIN GASTROENTEROL H, V4, P1154, DOI 10.1016/j.cgh.2006.06.011
   Woo YC, 2013, CLIN ENDOCRINOL, V78, P489, DOI 10.1111/cen.12095
   Wu D, 2013, HEPAT MON, V13, DOI 10.5812/hepatmon.6065
   Wu L, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-16312-6
   Xu AM, 2003, J CLIN INVEST, V112, P91, DOI 10.1172/JCI200317797
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Xu PF, 2016, TOXICOL APPL PHARM, V290, P43, DOI 10.1016/j.taap.2015.11.012
   Xu X, 2013, SEMIN LIVER DIS, V33, P301, DOI 10.1055/s-0033-1358523
   Yan HM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024895
   Yang CF, 2013, BMC GASTROENTEROL, V13, DOI 10.1186/1471-230X-13-67
   Yang SJ, 2011, J CLIN ENDOCR METAB, V96, pE1325, DOI 10.1210/jc.2011-0620
   Yi YS, 2003, BBA-MOL BASIS DIS, V1638, P249, DOI 10.1016/S0925-4439(03)00090-5
   Yilmaz Y, 2010, ANN CLIN BIOCHEM, V47, P549, DOI 10.1258/acb.2010.010169
   Yoon S, 2011, VIROLOGY, V409, P290, DOI 10.1016/j.virol.2010.10.024
   Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431
   Younossi ZM, 2011, CLIN GASTROENTEROL H, V9, P524, DOI 10.1016/j.cgh.2011.03.020
   Yu X, 2017, J HEPATOL, V66, P693, DOI 10.1016/j.jhep.2016.12.018
   Yu YH, 2016, INT IMMUNOPHARMACOL, V38, P144, DOI 10.1016/j.intimp.2016.05.026
   Zhang J, 2018, EXP THER MED, V15, P3189, DOI 10.3892/etm.2018.5840
   Zhang JX, 2021, FRONT MICROBIOL, V12, DOI 10.3389/fmicb.2021.636897
   Zhang LM, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.01086
   Zhang P, 2014, DIGEST DIS SCI, V59, P1789, DOI 10.1007/s10620-014-3071-0
   Zhang Q-Y., 2018, P 2017 2 INT C BIOL, DOI [10.2991/bst-17.2018.1, DOI 10.2991/BST-17.2018.1]
   Zhao J, 2021, ANN HEPATOL, V21, DOI 10.1016/j.aohep.2020.06.010
   Zheng QQ, 2020, THERANOSTICS, V10, P9923, DOI 10.7150/thno.45988
   Zhu LG, 2019, LIVER INT, V39, P70, DOI 10.1111/liv.13933
NR 315
TC 13
Z9 13
U1 1
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAR 9
PY 2022
VL 13
AR 814209
DI 10.3389/fendo.2022.814209
PG 21
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 0G3EY
UT WOS:000777932600001
PM 35355551
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zilioli, S
   Gómez, JM
   Jiang, YP
   Rodriguez-Stanley, J
AF Zilioli, Samuele
   Gomez, Jennifer M.
   Jiang, Yanping
   Rodriguez-Stanley, Jacqueline
TI Childhood Socioeconomic Status and Cardiometabolic Health: A Test of the
   John Henryism Hypothesis in African American Older Adults
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
DE Childhood SES; John Henryism; Metabolic syndrome; Systemic inflammation
ID BLOOD-PRESSURE; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; RACIAL
   DISPARITIES; LIFE-SPAN; STRESS; EDUCATION; RISK; SUSCEPTIBILITY;
   HYPERTENSION
AB Background John Henryism (JH) is a form of active high-effort coping. Low-socioeconomic status (SES) African Americans adopting JH to deal with structural racism and other chronic stressors might be more likely to display cardiovascular disease risk factors. Previous tests of this hypothesis have mostly focused on the moderating role of current SES and hypertension as the outcome variable. Furthermore, most of the previous work has been conducted among young and middle-aged adults. This study aimed at extending work on the JH hypothesis by testing the combined effect of JH and childhood SES on metabolic syndrome and systemic inflammation among African American older adults. Methods One hundred seventy urban African American older adults (M-age = 67.64 years, 75.9% female) were recruited. Participants completed questionnaires assessing JH, childhood SES, and other variables used as covariates (ie, demographic information, chronic conditions, medication use, and health behaviors). Blood pressure, waist circumference, and blood were also collected. Triglycerides, high-density lipoprotein cholesterol, hemoglobin A1C, and C-reactive protein levels were measured from the blood samples. Results JH was positively associated with metabolic syndrome symptoms among participants reporting low childhood SES levels, but not among those reporting high childhood SES levels. The same pattern did not emerge when we considered current SES. Similar patterns of results did not emerge as far as systemic inflammation was concerned. Conclusions Our findings highlight the importance of considering the joint impact of objective conditions early in life and individual psychological proclivities in explaining increased risk for cardiovascular disease risk in this population.
C1 [Zilioli, Samuele; Gomez, Jennifer M.; Rodriguez-Stanley, Jacqueline] Wayne State Univ, Dept Psychol, 5057 Woodward Ave, Detroit, MI 48202 USA.
   [Zilioli, Samuele] Wayne State Univ, Dept Family Med & Publ Hlth Sci, Detroit, MI 48202 USA.
   [Gomez, Jennifer M.] Ctr Inst Courage, Palo Alto, CA USA.
   [Jiang, Yanping] Rutgers State Univ, Inst Hlth Hlth Care Policy & Aging Res, New Brunswick, NJ USA.
   [Jiang, Yanping] Rutgers State Univ, Dept Family Med & Community Hlth, New Brunswick, NJ USA.
C3 Wayne State University; Wayne State University; Rutgers University
   System; Rutgers University New Brunswick; Rutgers University System;
   Rutgers University New Brunswick
RP Zilioli, S (corresponding author), Wayne State Univ, Dept Psychol, 5057 Woodward Ave, Detroit, MI 48202 USA.
EM fv0808@wayne.edu
RI Jiang, Yanping/ABC-6916-2021; Gomez, Jennifer/KJM-1479-2024
OI Jiang, Yanping/0000-0002-0931-9507; Zilioli,
   Samuele/0000-0002-1126-8913; Rodriguez-Stanley,
   Jacqueline/0000-0003-0422-9438
FU National Institutes of Health [P30 AG015281]; Michigan Center for Urban
   African American Aging Research (MCUAAAR); Faculty Competition for
   Postdoctoral Fellowship from Wayne State University; National Institute
   on Aging [P30AG015281] Funding Source: NIH RePORTER
FX This study was supported by a grant from the National Institutes of
   Health (P30 AG015281) and the Michigan Center for Urban African American
   Aging Research (MCUAAAR). The preparation of the manuscript was partly
   supported by a Faculty Competition for Postdoctoral Fellowship from
   Wayne State University (Samuele Zilioli).
CR Assari Shervin, 2019, J Health Econ Dev, V1, P1
   Assari S, 2018, CHILDREN-BASEL, V5, DOI 10.3390/children5060073
   Bennett GG, 2004, PSYCHOL HEALTH, V19, P369, DOI 10.1080/0887044042000193505
   Bild DE, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094916
   Brody GH, 2018, PSYCHOSOM MED, V80, P216, DOI 10.1097/PSY.0000000000000540
   Brody GH, 2013, PSYCHOL SCI, V24, P1285, DOI 10.1177/0956797612471954
   Chen E, 2018, INT J OBESITY, V42, P634, DOI 10.1038/ijo.2017.246
   Churchwell K, 2020, CIRCULATION, V142, pE454, DOI 10.1161/CIR.0000000000000936
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   COHEN S, 1993, AM J PUBLIC HEALTH, V83, P1277, DOI 10.2105/AJPH.83.9.1277
   Davis-Kean PE, 2005, J FAM PSYCHOL, V19, P294, DOI 10.1037/0893-3200.19.2.294
   Doan SN, 2016, APPL DEV SCI, V20, P310, DOI 10.1080/10888691.2016.1171716
   Dressler WW, 1998, PSYCHOSOM MED, V60, P620, DOI 10.1097/00006842-199809000-00019
   DUIJKERS TJ, 1988, PSYCHOSOM MED, V50, P353, DOI 10.1097/00006842-198807000-00004
   Farmer MM, 2005, SOC SCI MED, V60, P191, DOI 10.1016/j.socscimed.2004.04.026
   Felix AS, 2019, J URBAN HEALTH, V96, P12, DOI 10.1007/s11524-018-00333-1
   Ferdinand KC, 2017, J CLIN HYPERTENS, V19, P1015, DOI 10.1111/jch.13089
   Fernald LCH, 2008, J EPIDEMIOL COMMUN H, V62, DOI 10.1136/jech.2007.065219
   Fernander AF, 2004, J NATL MED ASSOC, V96, P246
   Ferraro KF, 2009, GERONTOLOGIST, V49, P333, DOI 10.1093/geront/gnp034
   GARN SM, 1975, PEDIATRICS, V56, P306
   Gustafsson PE, 2011, ANN EPIDEMIOL, V21, P103, DOI 10.1016/j.annepidem.2010.08.012
   Harrell SP, 2000, AM J ORTHOPSYCHIAT, V70, P42, DOI 10.1037/h0087722
   Hicken MT, 2018, SOC SCI MED, V199, P11, DOI 10.1016/j.socscimed.2017.12.027
   Ingram DD, 2015, DIFFERENCES STROKE M
   Jackson JS, 2010, AM J PUBLIC HEALTH, V100, P933, DOI 10.2105/AJPH.2008.143446
   JACKSON LA, 1994, J BEHAV MED, V17, P69, DOI 10.1007/BF01856883
   James SA, 2006, AM J PUBLIC HEALTH, V96, P812, DOI 10.2105/AJPH.2005.076158
   JAMES SA, 1994, CULT MED PSYCHIAT, V18, P163, DOI 10.1007/BF01379448
   Lucove JC, 2007, AM J PUBLIC HEALTH, V97, P234, DOI 10.2105/AJPH.2006.087429
   Lupien SJ, 2009, NAT REV NEUROSCI, V10, P434, DOI 10.1038/nrn2639
   McCabe CJ, 2018, ADV METH PRACT PSYCH, V1, P147, DOI 10.1177/2515245917746792
   McKetney EC, 1996, AM J EPIDEMIOL, V143, P787
   McLaren L, 2007, EPIDEMIOL REV, V29, P29, DOI 10.1093/epirev/mxm001
   Mendez MA, 2003, INT J EPIDEMIOL, V32, P400, DOI 10.1093/ije/dyg083
   Merritt MM, 2011, AM J GERIAT PSYCHIAT, V19, P451, DOI 10.1097/JGP.0b013e3181eaffa4
   Merritt MM, 2004, PSYCHOSOM MED, V66, P49, DOI 10.1097/01.PSY.0000107909.74904.3D
   Miller GE, 2011, PSYCHOL SCI, V22, P1591, DOI 10.1177/0956797611419170
   Miller GE, 2011, PSYCHOL BULL, V137, P959, DOI 10.1037/a0024768
   Mozaffarian D, 2016, CIRCULATION, V133, P187, DOI 10.1161/CIRCULATIONAHA.115.018585
   Nusslock R, 2016, BIOL PSYCHIAT, V80, P23, DOI 10.1016/j.biopsych.2015.05.017
   Ong KL, 2010, DIABETES CARE, V33, P1856, DOI 10.2337/dc10-0190
   Pampel FC, 2012, SOC SCI MED, V74, P1073, DOI 10.1016/j.socscimed.2011.12.028
   Pearson TA, 2003, CIRCULATION, V107, P499, DOI 10.1161/01.CIR.0000052939.59093.45
   Phillips JE, 2009, BRAIN BEHAV IMMUN, V23, P677, DOI 10.1016/j.bbi.2009.01.008
   Puolakka E, 2016, DIABETES CARE, V39, P2311, DOI 10.2337/dc16-1565
   Radler BT, 2010, J AGING HEALTH, V22, P307, DOI 10.1177/0898264309358617
   Rangrass G, 2014, JAMA SURG, V149, P223, DOI 10.1001/jamasurg.2013.4041
   Ridker PM, 2003, CIRCULATION, V107, P363, DOI 10.1161/01.CIR.0000053730.47739.3C
   Subramanyam MA, 2013, SOC SCI MED, V93, P139, DOI 10.1016/j.socscimed.2013.06.016
   Tamayo T, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-525
   TAYLOR HL, 1978, J CHRON DIS, V31, P741, DOI 10.1016/0021-9681(78)90058-9
   Taylor SE, 2007, ANNU REV CLIN PSYCHO, V3, P377, DOI 10.1146/annurev.clinpsy.3.022806.091520
   Umer A, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4691-z
   Whelton PK, 2018, HYPERTENSION, V71, pE13, DOI [10.1161/HYP.0000000000000066, 10.1161/HYP.0000000000000065]
   WIIST WH, 1992, J BEHAV MED, V15, P15, DOI 10.1007/BF00848375
   Williams D R, 1997, J Health Psychol, V2, P335, DOI 10.1177/135910539700200305
NR 57
TC 5
Z9 7
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
EI 1758-535X
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD FEB 3
PY 2022
VL 77
IS 2
BP E56
EP E64
DI 10.1093/gerona/glab280
EA OCT 2021
PG 9
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA YZ0YU
UT WOS:000755209900003
PM 34569595
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Kojadinovic, MI
   Arsic, AC
   Debeljak-Martacic, JD
   Konic-Ristic, AI
   Kardum, ND
   Popovic, TB
   Glibetic, MD
AF Kojadinovic, Milica I.
   Arsic, Aleksandra C.
   Debeljak-Martacic, Jasmina D.
   Konic-Ristic, Aleksandra I.
   Kardum, Nevena Dj
   Popovic, Tamara B.
   Glibetic, Marija D.
TI Consumption of pomegranate juice decreases blood lipid peroxidation and
   levels of arachidonic acid in women with metabolic syndrome
SO JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
LA English
DT Article
DE metabolic syndrome; pomegranate juice; fatty acid; arachidonic acid;
   lipid peroxidation
ID ESTIMATED DESATURASE ACTIVITIES; RADICAL-SCAVENGING ACTIVITY; OXIDATIVE
   STRESS; ANTIOXIDANT ACTIVITY; FATTY-ACIDS; DIABETIC-PATIENTS; ELLAGIC
   ACID; RISK; OBESITY; MEN
AB BACKGROUNDPomegranate juice is a rich source of polyphenols and is thus a promising dietary antioxidant with numerous health-promoting effects. These include a beneficial impact on cardiovascular health that could be partly attributed to the effects of polyphenols on lipid metabolism. The aim of this study was to investigate whether consumption of pomegranate juice for 6 weeks could modify lipid peroxidation and phospholipid fatty acid composition of plasma and erythrocytes in subjects with metabolic syndrome. Twenty-three women, aged 40-60 years, were enrolled and randomly assigned into two groups: the intervention group, in which each participant consumed 300 mL of juice per day for 6 weeks; and a control group.
   RESULTSA statistically significant decrease in the relative amount of arachidonic acid (P < 0.05) and an increase in the relative amount of saturated fatty acids (P < 0.05) were observed in the intervention group at the end of the consumption period. In addition, pomegranate juice significantly increased the relative amount of total mono-unsaturated fatty acids (P < 0.05), and significantly decreased the levels of thiobarbituric acid reactive substances in erythrocytes (P < 0.05). The status of blood lipids and the values for blood pressure were not changed during the study.
   CONCLUSIONThe results obtained indicate a positive impact of the consumption of pomegranate juice on lipid peroxidation and fatty acid status in subjects with metabolic syndrome and suggest potential anti-inflammatory and cardio-protective effects. (c) 2016 Society of Chemical Industry
C1 [Kojadinovic, Milica I.; Arsic, Aleksandra C.; Debeljak-Martacic, Jasmina D.; Konic-Ristic, Aleksandra I.; Kardum, Nevena Dj; Popovic, Tamara B.; Glibetic, Marija D.] Univ Belgrade, Inst Med Res, Ctr Res Excellence Nutr & Metab, Tadeusa Koscuska 1, Belgrade 11129, Serbia.
C3 University of Belgrade
RP Kojadinovic, MI (corresponding author), Univ Belgrade, Inst Med Res, Ctr Res Excellence Nutr & Metab, Tadeusa Koscuska 1, Belgrade 11129, Serbia.
EM aristokratija@yahoo.com
RI Vidovic, Nevena/AFT-1529-2022; Konic Ristic, Aleksandra/KDM-9154-2024;
   Konic Ristic, Aleksandra/D-7634-2014
OI Arsic, Aleksandra/0000-0001-8498-9415; Konic Ristic,
   Aleksandra/0000-0002-1218-1190; Debeljak Martacic,
   Jasmina/0000-0002-9605-3793; Kardum Vidovic, Nevena/0000-0001-6931-3695
FU Ministry of Science of the Republic of Serbia [41030]
FX This work was supported by Project 41030 financed by the Ministry of
   Science of the Republic of Serbia.
CR Ajmo JM, 2008, AM J PHYSIOL-GASTR L, V295, pG833, DOI 10.1152/ajpgi.90358.2008
   Amakura Y, 2000, J CHROMATOGR A, V891, P183, DOI 10.1016/S0021-9673(00)00625-7
   [Anonymous], 2000, APPR METH AN
   Aoun M, 2010, BRIT J NUTR, V104, P1760, DOI 10.1017/S0007114510002850
   Arts ICW, 2005, AM J CLIN NUTR, V81, p317S, DOI 10.1093/ajcn/81.1.317S
   Aviram M, 2001, ATHEROSCLEROSIS, V158, P195, DOI 10.1016/S0021-9150(01)00412-9
   Aviram M, 2000, AM J CLIN NUTR, V71, P1062
   Bakir S, 2015, ARCH PHYSIOL BIOCHEM, V121, P152, DOI 10.3109/13813455.2015.1068336
   Basu A, 2013, J NUTR METAB, V2013, DOI 10.1155/2013/708381
   Berkemeyer S, 2010, MED HYPOTHESES, V75, P59, DOI 10.1016/j.mehy.2009.12.034
   Boadi WY, 2005, J APPL TOXICOL, V25, P82, DOI 10.1002/jat.1049
   Braca A, 2001, J NAT PROD, V64, P892, DOI 10.1021/np0100845
   Çam M, 2009, FOOD CHEM, V112, P721, DOI 10.1016/j.foodchem.2008.06.009
   Chang CC, 2002, J FOOD DRUG ANAL, V10, P178
   Chen CK, 1996, GEN PHARMACOL-VASC S, V27, P363
   Chun OK, 2003, J AGR FOOD CHEM, V51, P8067, DOI 10.1021/jf034740d
   Clarke R, 2009, BRIT J NUTR, V102, P279, DOI 10.1017/S0007114508143562
   Davidson MH, 2009, AM J CARDIOL, V104, P936, DOI 10.1016/j.amjcard.2009.05.037
   de Souza RJ, 2015, BMJ-BRIT MED J, V351, DOI 10.1136/bmj.h3978
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Esmaillzadeh A, 2004, J MED FOOD, V7, P305, DOI 10.1089/1096620041938623
   Falsaperla M, 2005, EUR UROL, V47, P449, DOI 10.1016/j.eururo.2004.12.001
   Fenercioglu AK, 2010, J ENDOCRINOL INVEST, V33, P118, DOI 10.3275/6564
   Gatti M, 2011, VITIS, V50, P43
   Gil MI, 2000, J AGR FOOD CHEM, V48, P4581, DOI 10.1021/jf000404a
   Grattagliano I, 2008, J NUTR BIOCHEM, V19, P491, DOI 10.1016/j.jnutbio.2007.06.011
   Guo CJ, 2008, NUTR RES, V28, P72, DOI 10.1016/j.nutres.2007.12.001
   HANASAKI Y, 1994, FREE RADICAL BIO MED, V16, P845, DOI 10.1016/0891-5849(94)90202-X
   Hassoun EA, 2004, J BIOCHEM MOL TOXIC, V18, P196, DOI 10.1002/jbt.20030
   Heber D, 2007, J AGR FOOD CHEM, V55, P10050, DOI 10.1021/jf071689v
   Heijnen CGM, 2002, FREE RADICAL RES, V36, P575, DOI 10.1080/10715760290025951
   Hmid I., 2017, Arabian Journal of Chemistry, VS2684, DOI DOI 10.1016/J.ARABJC.2013.10.011
   Hooper L, 2008, AM J CLIN NUTR, V88, P38, DOI 10.1093/ajcn/88.1.38
   Hu FB, 1997, NEW ENGL J MED, V337, P1491, DOI 10.1056/NEJM199711203372102
   Ismail T, 2012, J ETHNOPHARMACOL, V143, P397, DOI 10.1016/j.jep.2012.07.004
   Jovanovic SV, 2000, ANN NY ACAD SCI, V899, P326, DOI 10.1111/j.1749-6632.2000.tb06197.x
   Kahn BB, 2000, J CLIN INVEST, V106, P473, DOI 10.1172/JCI10842
   Kawakami Y, 2005, J CLIN BIOCHEM NUTR, V37, P95, DOI 10.3164/jcbn.37.95
   Kawashima A, 2009, J NUTR SCI VITAMINOL, V55, P400, DOI 10.3177/jnsv.55.400
   Kelishadi R, 2011, J RES MED SCI, V16, P245
   Klaus S, 2005, INT J OBESITY, V29, P615, DOI 10.1038/sj.ijo.0802926
   Konic-Ristic A, 2011, FOOD CHEM, V125, P1412, DOI 10.1016/j.foodchem.2010.10.018
   Lynn A, 2012, PLANT FOOD HUM NUTR, V67, P309, DOI 10.1007/s11130-012-0295-z
   Masci A, 2016, FOOD CHEM, V202, P59, DOI 10.1016/j.foodchem.2016.01.106
   Mayneris-Perxachs J, 2014, CLIN NUTR, V33, P90, DOI 10.1016/j.clnu.2013.03.001
   Monteiro R, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/289645
   Mousavinejad G, 2009, FOOD CHEM, V115, P1274, DOI 10.1016/j.foodchem.2009.01.044
   Nakao M, 1998, PHYTOCHEMISTRY, V49, P2379, DOI 10.1016/S0031-9422(98)00333-1
   Ogino Y, 2007, LIPIDS, V42, P151, DOI 10.1007/s11745-006-3008-2
   Olszanecki R, 2002, J PHYSIOL PHARMACOL, V53, P571
   Pollard SE, 2006, BIOCHEM BIOPH RES CO, V350, P960, DOI 10.1016/j.bbrc.2006.09.131
   Ristic-Medic DVV, 2013, J NUTR HLTH FOOD SCI, V1, P1, DOI DOI 10.15226/JNHFS.2013.00105
   Roche HM, 2005, P NUTR SOC, V64, P23, DOI 10.1079/PNS2004405
   Rock W, 2008, J AGR FOOD CHEM, V56, P8704, DOI 10.1021/jf801756x
   Tepsic J, 2009, EUR J APPL PHYSIOL, V107, P359, DOI 10.1007/s00421-009-1131-5
   Waterman GP, 1994, ANAL PHENOLIC PLANT, P16
   [William HorwitzW. AOAC International AOAC International], 2000, Official methods of analysis of AOAC International, VI.
   Woodcock ME, 2013, J SCI FOOD AGR, V93, P3574, DOI [10.1002/jsfa.6328, 10.1002/jsfa.6251]
   Zang MW, 2006, DIABETES, V55, P2180, DOI 10.2337/db05-1188
NR 59
TC 54
Z9 59
U1 1
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-5142
EI 1097-0010
J9 J SCI FOOD AGR
JI J. Sci. Food Agric.
PD APR
PY 2017
VL 97
IS 6
BP 1798
EP 1804
DI 10.1002/jsfa.7977
PG 7
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA EP7RP
UT WOS:000397575200016
PM 27476699
DA 2025-06-11
ER

PT J
AU Vafaeipour, Z
   Razavi, BM
   Hosseinzadeh, H
AF Vafaeipour, Zeinab
   Razavi, Bibi Marjan
   Hosseinzadeh, Hossein
TI Effects of turmeric (Curcuma longa) and its constituent (curcumin) on
   the metabolic syndrome: An updated review
SO JOURNAL OF INTEGRATIVE MEDICINE-JIM
LA English
DT Review
DE Turmeric; Curcuma longa; Curcumin; Metabolic syndrome; Diabetes;
   Hyperlipidemia
ID TYPE-2 DIABETES-MELLITUS; FATTY LIVER-DISEASE; RANDOMIZED
   CONTROLLED-TRIAL; INDUCED LIPID-ACCUMULATION; OXIDATIVE STRESS;
   DOUBLE-BLIND; ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; MOLECULAR
   TARGETS; ACTIVE PRINCIPLE
AB Metabolic syndrome (MS) involves people with the following risk factors: obesity, hypertension, high glucose level and hyperlipidemia. It can increase the risk of heart disease, stroke and type 2 diabetes mellitus. The prevalence of MS in the world's adult population is about 20%-25%. Today, there is much care to use medicinal plants. Turmeric (Curcuma longa) as well as curcumin which is derived from the rhizome of the plant, has been shown beneficial effects on different components of MS. Thus, the purpose of this manuscript was to introduce different in vitro, in vivo and human studies regarding the effect of turmeric and its constituent on MS. Moreover, different mechanisms of action by which this plant overcomes MS have been introduced. Based on studies, turmeric and its bioactive component, curcumin, due to their anti-inflammatory and antioxidant properties, have antidiabetic effects through increasing insulin release, antihyperlipidemic effects by increasing fatty acid uptake, anti-obesity effects by decreasing lipogenesis, and antihypertensive effects by increasing nitric oxide. According to several in vivo, in vitro and human studies, it can be concluded that turmeric or curcumin has important values as a complementary therapy in MS. However, more clinical trials should be done to confirm these effects.
   Please cite this article as: Vafaeipour Z, Razavi BM, Hosseinzadeh H. Effects of turmeric (Curcuma longa) and its constituent (curcumin) on the metabolic syndrome: An updated review. J Integr Med. 2022; 20(3): 193-203. (c) 2022 Shanghai Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. Published by Elsevier B.V. All rights reserved.
C1 [Vafaeipour, Zeinab] Mashhad Univ Med Sci, Student Res Comm, Mashhad 9177948954, Razavi Khorasan, Iran.
   [Vafaeipour, Zeinab; Razavi, Bibi Marjan; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad 9177948954, Razavi Khorasan, Iran.
   [Razavi, Bibi Marjan] Mashhad Univ Med Sci, Targeted Drug Delivery Res Ctr, Pharmaceut Technol Inst, Mashhad 9177948954, Razavi Khorasan, Iran.
   [Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad 9177948954, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad 9177948954, Razavi Khorasan, Iran.
EM hosseinzadehh@mums.ac.ir
RI Razavi, Bibi/AAY-5636-2020; Hosseinzadeh, Hossein/F-3013-2010
CR Adab Z, 2019, PHYTOTHER RES, V33, P1173, DOI 10.1002/ptr.6312
   Adaramoye OA, 2009, J ETHNOPHARMACOL, V124, P457, DOI 10.1016/j.jep.2009.05.021
   Ahmad S, 2013, LIPIDS HEALTH DIS, V12, DOI 10.1186/1476-511X-12-86
   Akbar MU, 2018, INT J BIOL MACROMOL, V120, P2418, DOI 10.1016/j.ijbiomac.2018.09.010
   Akinyemi AJ, 2016, PHYTOTHER RES, V30, P1156, DOI 10.1002/ptr.5621
   Al-Ali K, 2016, BIOL PHARM BULL, V39, P1774, DOI 10.1248/bpb.b16-00137
   Alappat L, 2010, NUTR REV, V68, P729, DOI 10.1111/j.1753-4887.2010.00341.x
   Ali Hussain Halim Eshrat M, 2002, Indian J Clin Biochem, V17, P33, DOI 10.1007/BF02867969
   Alwi Idrus, 2008, Acta Med Indones, V40, P201
   Amin F, 2015, COMPLEMENT THER MED, V23, P165, DOI 10.1016/j.ctim.2015.01.008
   Amini A, 2019, J CELL BIOCHEM, V120, P17994, DOI 10.1002/jcb.29102
   Anderson WP, 2000, HYPERTENSION, V36, P648, DOI 10.1161/01.HYP.36.4.648
   Arun N, 2002, PLANT FOOD HUM NUTR, V57, P41, DOI 10.1023/A:1013106527829
   Asadi S, 2019, COMPLEMENT THER MED, V43, P253, DOI 10.1016/j.ctim.2019.02.014
   Asai A, 2001, J NUTR, V131, P2932, DOI 10.1093/jn/131.11.2932
   Babu PS, 1997, MOL CELL BIOCHEM, V166, P169, DOI 10.1023/A:1006819605211
   Banafshe HR, 2014, EUR J PHARMACOL, V723, P202, DOI 10.1016/j.ejphar.2013.11.033
   Boonla O, 2014, NITRIC OXIDE-BIOL CH, V42, P44, DOI 10.1016/j.niox.2014.09.001
   Bosca AR, 1997, AGE, V20, P165, DOI 10.1007/s11357-997-0015-z
   Bradford PG, 2013, BIOFACTORS, V39, P78, DOI 10.1002/biof.1074
   Bulboaca A, 2016, IRAN J BASIC MED SCI, V19, P585
   Byun SY, 2015, NUTR RES, V35, P726, DOI 10.1016/j.nutres.2015.05.016
   Cai Y, 2017, BIOORG MED CHEM LETT, V27, P1835, DOI 10.1016/j.bmcl.2017.02.045
   Cheng TC, 2009, NEUROSCI LETT, V465, P238, DOI 10.1016/j.neulet.2009.09.012
   Chuengsamarn S, 2014, J NUTR BIOCHEM, V25, P144, DOI 10.1016/j.jnutbio.2013.09.013
   Chuengsamarn S, 2012, DIABETES CARE, V35, P2121, DOI 10.2337/dc12-0116
   Cicero AFG, 2020, EUR J NUTR, V59, P477, DOI 10.1007/s00394-019-01916-7
   Cicero AFG, 2018, NUTRIENTS, V10, DOI 10.3390/nu10091153
   Cicero AFG, 2017, FOOD FUNCT, V8, P2076, DOI [10.1039/c7fo00178a, 10.1039/C7FO00178A]
   Dehghani S, 2019, IRAN J BASIC MED SCI, V22, P460, DOI 10.22038/IJBMS.2019.31964.7678
   Di Pierro F, 2015, EUR REV MED PHARMACO, V19, P4195
   Ding LL, 2016, TOXICOL APPL PHARM, V304, P99, DOI 10.1016/j.taap.2016.05.011
   DOLLERY CM, 1995, CIRC RES, V77, P863, DOI 10.1161/01.RES.77.5.863
   Eisvand F, 2020, PHYTOTHER RES, V34, P1798, DOI 10.1002/ptr.6646
   Ejaz A, 2009, J NUTR, V139, P919, DOI 10.3945/jn.108.100966
   El-Moselhy MA, 2011, FOOD CHEM TOXICOL, V49, P1129, DOI 10.1016/j.fct.2011.02.004
   Förstermann U, 2008, NAT CLIN PRACT CARD, V5, P338, DOI 10.1038/ncpcardio1211
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Ganjali S, 2017, PHARMACOL RES, V119, P208, DOI 10.1016/j.phrs.2017.02.008
   Ghaffari A, 2019, INT J VITAM NUTR RES, V89, P293, DOI 10.1024/0300-9831/a000568
   Ghasemi H, 2019, IRAN J BASIC MED SCI, V22, P376, DOI 10.22038/ijbms.2019.31922.7674
   Ghorbani Z, 2014, INT J ENDOCRINOL MET, V12, DOI 10.5812/ijem.18081
   Grama CN, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0078217
   Hajavi J, 2017, J CELL BIOCHEM, V118, P4170, DOI 10.1002/jcb.26121
   Han JM, 2015, J ETHNOPHARMACOL, V173, P217, DOI 10.1016/j.jep.2015.07.021
   Han Y, 2019, J NUTR BIOCHEM, V72, DOI 10.1016/j.jnutbio.2019.07.003
   Hassani FV, 2016, N-S ARCH PHARMACOL, V389, P931, DOI 10.1007/s00210-016-1256-0
   Hatamipour M, 2021, ADV EXP MED BIOL, V1308, P37, DOI 10.1007/978-3-030-64872-5_4
   He HJ, 2012, WORLD J DIABETES, V3, P94, DOI 10.4239/wjd.v3.i5.94
   Hewlings SJ, 2017, FOODS, V6, DOI 10.3390/foods6100092
   Hlavacková L, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-72
   Ho JN, 2012, J SCI FOOD AGR, V92, P1833, DOI 10.1002/jsfa.5592
   Hodaei H, 2019, DIABETOL METAB SYNDR, V11, DOI 10.1186/s13098-019-0437-7
   Honda S, 2006, J AGR FOOD CHEM, V54, P9055, DOI 10.1021/jf061788t
   Horikawa Y, 2000, NAT GENET, V26, P163, DOI 10.1038/79876
   Hsu SJ, 2017, BIOSCIENCE REP, V37, DOI [10.1042/BSR20171015, 10.1042/bsr20171015]
   Hu B, 2017, J FOOD DRUG ANAL, V25, P3, DOI 10.1016/j.jfda.2016.11.004
   Hu J, 2017, EXP THER MED, V14, P5896, DOI 10.3892/etm.2017.5318
   Humphrey JD, 2008, HYPERTENSION, V52, P195, DOI 10.1161/HYPERTENSIONAHA.107.103440
   Hwang LC, 2006, J FORMOS MED ASSOC, V105, P626, DOI 10.1016/S0929-6646(09)60161-3
   Jafarinezhad Z, 2019, FOOD SCI NUTR, V7, P3581, DOI 10.1002/fsn3.1210
   Jain SK, 2009, ANTIOXID REDOX SIGN, V11, P241, DOI 10.1089/ars.2008.2140
   Jang EM, 2008, METABOLISM, V57, P1576, DOI 10.1016/j.metabol.2008.06.014
   Kam TS, 2012, J MED FOOD, V15, P190, DOI 10.1089/jmf.2011.1625
   Kang OH, 2013, EUR REV MED PHARMACO, V17, P2578
   Karlowicz-Bodalska K, 2017, ACTA POL PHARM, V74, P605
   Khajehdehi P, 2012, J RENAL NUTR, V22, P50, DOI 10.1053/j.jrn.2011.03.002
   Khajehdehi P, 2011, SCAND J UROL NEPHROL, V45, P365, DOI 10.3109/00365599.2011.585622
   Kim JH, 2016, FOOD NUTR RES, V60, DOI 10.3402/fnr.v60.30428
   Kim Mi-Bo, 2014, Evid Based Complement Alternat Med, V2014, P205915, DOI 10.1155/2014/205915
   Kumar GS, 2014, J DIABETES METAB DIS, V13, DOI 10.1186/2251-6581-13-78
   Lan C, 2018, BMC CARDIOVASC DISOR, V18, DOI 10.1186/s12872-018-0768-6
   Lee CH, 2014, FOOD SCI BIOTECHNOL, V23, P261, DOI 10.1007/s10068-014-0036-1
   Lee MY, 2008, ANTIOXID REDOX SIGN, V10, P1045, DOI 10.1089/ars.2007.1986
   Lemarié CA, 2010, J MOL CELL CARDIOL, V48, P433, DOI 10.1016/j.yjmcc.2009.09.018
   Li ZY, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0120950
   Madkor HR, 2011, BRIT J NUTR, V105, P1210, DOI 10.1017/S0007114510004927
   Maithilikarpagaselvi N, 2016, PHARM BIOL, V54, P2857, DOI 10.1080/13880209.2016.1187179
   Manzoni AG, 2019, BLOOD CELL MOL DIS, V76, P13, DOI 10.1016/j.bcmd.2018.12.005
   McCullough AJ, 2011, J DIGEST DIS, V12, P333, DOI 10.1111/j.1751-2980.2010.00469.x
   Mohankumar S, 2011, PHYTOTHER RES, V25, P396, DOI 10.1002/ptr.3275
   Mohanty I, 2004, LIFE SCI, V75, P1701, DOI 10.1016/j.lfs.2004.02.032
   Mollazadeh H, 2019, PHYTOMEDICINE, V53, P43, DOI 10.1016/j.phymed.2018.09.024
   Mollazadeh H, 2016, IRAN J BASIC MED SCI, V19, P1258, DOI 10.22038/ijbms.2016.7906
   Mrudula T, 2007, BIOCHEM BIOPH RES CO, V361, P528, DOI 10.1016/j.bbrc.2007.07.059
   Murugan P, 2008, J BIOSCIENCES, V33, P63, DOI 10.1007/s12038-008-0022-y
   Mustafa SB, 2019, DOSE-RESPONSE, V17, DOI 10.1177/1559325819852503
   Nakmareong S, 2011, N-S ARCH PHARMACOL, V383, P519, DOI 10.1007/s00210-011-0624-z
   Nishiyama T, 2005, J AGR FOOD CHEM, V53, P959, DOI 10.1021/jf0483873
   Okada T, 2006, DIABETES, V55, P1666, DOI 10.2337/db05-1285
   Öner-Iyidogan Y, 2017, J FOOD BIOCHEM, V41, DOI 10.1111/jfbc.12347
   Öner-Iyidogan Y, 2014, CAN J PHYSIOL PHARM, V92, P805, DOI 10.1139/cjpp-2014-0174
   Öner-Iyidogan Y, 2013, J PHYSIOL BIOCHEM, V69, P677, DOI 10.1007/s13105-013-0244-9
   Panahi Y, 2017, COMPLEMENT THER MED, V33, P1, DOI 10.1016/j.ctim.2017.05.006
   Panahi Y, 2017, INFLAMMOPHARMACOLOGY, V25, P25, DOI 10.1007/s10787-016-0301-4
   Panahi Y, 2016, J CARDIOVASC PHARM, V68, P223, DOI 10.1097/FJC.0000000000000406
   Panahi Y, 2015, CLIN NUTR, V34, P1101, DOI 10.1016/j.clnu.2014.12.019
   Pari L, 2007, FUND CLIN PHARMACOL, V21, P665, DOI 10.1111/j.1472-8206.2007.00542.x
   Patti AM, 2018, ARCH MED SCI, V14, P422, DOI 10.5114/aoms.2017.68717
   Poolsup N, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0215840
   Prakash UNS, 2012, J SCI FOOD AGR, V92, P503, DOI 10.1002/jsfa.4597
   Prasannarong M, 2012, BMC COMPLEM ALTERN M, V12, DOI 10.1186/1472-6882-12-28
   Puddu P, 2008, BLOOD PRESSURE, V17, P70, DOI 10.1080/08037050802029954
   Rahmani S, 2016, PHYTOTHER RES, V30, P1540, DOI 10.1002/ptr.5659
   Rai PK, 2010, INDIAN J CLIN BIOCHE, V25, P175, DOI 10.1007/s12291-010-0032-z
   Ramaswami G, 2004, J VASC SURG, V40, P1216, DOI 10.1016/j.jvs.2004.09.021
   Ramírez-Tortosa MC, 1999, ATHEROSCLEROSIS, V147, P371, DOI 10.1016/S0021-9150(99)00207-5
   RamirezBosca A, 1995, AGE, V18, P167, DOI 10.1007/BF02432631
   Rastogi M, 2008, FREE RADICAL RES, V42, P999, DOI 10.1080/10715760802571988
   Razavi BM, 2014, J ENDOCRINOL INVEST, V37, P1031, DOI 10.1007/s40618-014-0150-1
   Roxo DF, 2019, DIABETOL METAB SYNDR, V11, DOI 10.1186/s13098-019-0431-0
   Rukkumani R, 2005, J MED FOOD, V8, P256, DOI 10.1089/jmf.2005.8.256
   Rungseesantivanon S, 2010, BMC COMPLEM ALTERN M, V10, DOI 10.1186/1472-6882-10-57
   Sahebkar A, 2013, BIOFACTORS, V39, P197, DOI 10.1002/biof.1062
   Samuhasaneeto S, 2009, J BIOMED BIOTECHNOL, DOI 10.1155/2009/981963
   Sanati S, 2018, IRAN J BASIC MED SCI, V21, P439, DOI 10.22038/IJBMS.2018.25200.6238
   Jiménez-Osorio AS, 2016, BIOFACTORS, V42, P561, DOI 10.1002/biof.1302
   Selvi NMK, 2015, INDIAN J CLIN BIOCHE, V30, P180, DOI 10.1007/s12291-014-0436-2
   Shakib Z, 2019, PHYTOTHER RES, V33, P2649, DOI 10.1002/ptr.6465
   Sharma S, 2006, CLIN EXP PHARMACOL P, V33, P940, DOI 10.1111/j.1440-1681.2006.04468.x
   Shehzad A, 2010, DRUG FUTURE, V35, P113, DOI 10.1358/dof.2010.035.02.1426640
   Shin SK, 2011, MOL NUTR FOOD RES, V55, P1829, DOI 10.1002/mnfr.201100440
   Simental-Mendía LE, 2019, OBES RES CLIN PRACT, V13, P340, DOI 10.1016/j.orcp.2019.04.003
   Singh V, 2015, BRIT J NUTR, V113, P100, DOI 10.1017/S0007114514003195
   Suryanarayana P, 2007, MED SCI MONITOR, V13, pBR286
   Tabeshpour J, 2017, IRAN J BASIC MED SCI, V20, P557, DOI 10.22038/IJBMS.2017.8682
   Tabeshpour J, 2017, PHYTOTHER RES, V31, P819, DOI 10.1002/ptr.5805
   Tajmohammadi A, 2018, PHYTOTHER RES, V32, P1933, DOI 10.1002/ptr.6153
   Uchio R, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081822
   Um MY, 2014, NUTR RES, V34, P886, DOI 10.1016/j.nutres.2014.09.001
   Wang SB, 2017, CLIN EXP HYPERTENS, V39, P711, DOI 10.1080/10641963.2017.1313854
   Weisberg SP, 2008, ENDOCRINOLOGY, V149, P3549, DOI 10.1210/en.2008-0262
   Wickenberg J, 2010, NUTR J, V9, DOI 10.1186/1475-2891-9-43
   Wojcik M, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/9698258
   Wu LY, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102307
   Xie XY, 2012, PHYTOMEDICINE, V20, P3, DOI 10.1016/j.phymed.2012.09.003
   Xu PH, 2007, VASC PHARMACOL, V47, P25, DOI 10.1016/j.vph.2007.03.003
   Xu XG, 2018, INFLAMMOPHARMACOLOGY, V26, P1257, DOI 10.1007/s10787-018-0449-1
   Yao YG, 2016, SCI REP-UK, V6, DOI 10.1038/srep25579
   Yiu WF, 2011, J FOOD SCI, V76, pH80, DOI 10.1111/j.1750-3841.2011.02042.x
   Zhang DW, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/636053
   Zhao JF, 2012, MOL NUTR FOOD RES, V56, P691, DOI 10.1002/mnfr.201100735
   Zhao JO, 2011, MOL CELL BIOCHEM, V351, P19, DOI 10.1007/s11010-010-0707-z
   Zhao XA, 2018, BIOMED PHARMACOTHER, V106, P868, DOI 10.1016/j.biopha.2018.07.028
   Zingg JM, 2017, BIOFACTORS, V43, P42, DOI 10.1002/biof.1307
   Zingg JM, 2013, BIOFACTORS, V39, P101, DOI 10.1002/biof.1072
   Zingg JM, 2012, J CELL BIOCHEM, V113, P833, DOI 10.1002/jcb.23411
   Zou J, 2018, NUTR RES, V56, P32, DOI 10.1016/j.nutres.2018.04.017
NR 148
TC 32
Z9 36
U1 6
U2 21
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2095-4964
J9 J INTEGR MED-JIM
JI J. Integr. Med.-JIM
PD MAY
PY 2022
VL 20
IS 3
BP 193
EP 203
DI 10.1016/j.joim.2022.02.008
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 7U0CV
UT WOS:000911807200002
PM 35292209
DA 2025-06-11
ER

PT J
AU Jang, I
   Kim, JS
   Kim, M
   Lee, E
AF Jang, Insil
   Kim, Ji-Su
   Kim, Minhae
   Lee, Eunkyung
TI Assessing Information Needs Regarding Metabolic Syndrome Among
   Gynecological Cancer Survivors A Concurrent Mixed Method
SO CANCER NURSING
LA English
DT Article
DE Cancer survivors; Gynecological cancer; Information need; Knowledge
   deficits; Metabolic syndrome; Survivorship
ID HEALTH BEHAVIOR-THEORY; KNOWLEDGE; BREAST; RISK; INTERVENTION;
   ASSOCIATION; PREVENTION; MANAGEMENT; AWARENESS; OBESITY
AB Background Cancer survivors have an increased risk of non-cancer-related deaths, particularly metabolic syndrome (MetS). Objective We aimed to assess knowledge deficits regarding metabolism-related diseases among gynecological cancer survivors and the preferred source of health information. Methods Using a mixed methods approach, 70 participants responded to a structured modified version of the MetS questionnaire. We conducted 28 semistructured interviews of gynecological cancer survivors with MetS. Responses were independently coded by 2 researchers, including MetS knowledge, behaviors for self-management, and preferred learning methods. Results Metabolic syndrome was diagnosed in 17% of the participants. More than 50% of the participants wanted to learn about MetS and requested a consultation with healthcare providers, 70% reported that they had heard of MetS, and 61.4% reported that they had MetS-related knowledge (correct answer rate by MetS-related component, similar to 50%). The level of MetS-related knowledge was poor in both the quantitative and qualitative data. Most of the participants defined MetS-related self-management health behaviors as regular eating and exercise in their own words. Participants mostly wanted exercise management (29% of the participants), followed by dietary life management (27.4%), stress management (17.4%), weight management (13.7%), definition and diagnostic methods of MetS (9.1%), and smoking and drinking management (3.3%). Participants wished to use a handbook in small groups or receive counseling by healthcare providers. Conclusion We observed poor awareness and knowledge level and the need for information regarding MetS among gynecological cancer surviv
C1 [Jang, Insil] Univ Ulsan, Dept Nursing, Ulsan, South Korea.
   [Kim, Ji-Su] Chung Ang Univ, Dept Nursing, 84 Heukseok Ro, Seoul, South Korea.
   [Kim, Minhae] Natl Canc Ctr, Dept Nursing, Goyang Si, Gyeonggi Do, South Korea.
   [Lee, Eunkyung] Kyung In Womens Univ, Dept Nursing, Incheon, South Korea.
C3 University of Ulsan; Chung Ang University; National Cancer Center -
   Korea (NCC)
RP Kim, JS (corresponding author), Chung Ang Univ, Dept Nursing, 84 Heukseok Ro, Seoul, South Korea.
EM jisu80@cau.ac.kr
RI Kim, Kyung/I-5501-2015; JANG, INSIL/AAS-2263-2020
OI Kim, Ji-Su/0000-0002-9512-1934
FU National Research Foundation of Korea [NRF-2015R1C1A1A02036408]
FX This study was funded by the National Research Foundation of Korea
   (NRF-2015R1C1A1A02036408).
CR [Anonymous], 2017, MEDWORLD NEWS   1106
   Athyros Vasilios G, 2005, Hellenic J Cardiol, V46, P380
   Becker Bettina-Maria, 2008, Psychol Health Med, V13, P367, DOI 10.1080/13548500701405525
   Bhandari R, 2014, INT J BREAST CANCER, V2014, DOI 10.1155/2014/189384
   Cantiello F, 2015, INT J UROL, V22, P22, DOI 10.1111/iju.12644
   Centers for Disease Control and Prevention, WHAT IS GYN CANC
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Creswell JW., 2015, CONCISE INTRO MIXED
   des Bordes JKA, 2016, J CANCER SURVIV, V10, P480, DOI 10.1007/s11764-015-0491-6
   Ferlay J, 2015, INT J CANCER, V136, pE359, DOI 10.1002/ijc.29210
   Fishbein M, 2001, HANDBOOK OF HEALTH PSYCHOLOGY, P3
   Fisher J., 2002, Emerging Theories in Health Promotion Practice and Research: Strategies for Improving Public Health
   Fisher JD, 2002, HEALTH PSYCHOL, V21, P177, DOI 10.1037//0278-6133.21.2.177
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Hawkes AL, 2011, EUR J CANCER, V47, P267, DOI 10.1016/j.ejca.2010.10.002
   Hibbard JH, 2007, HEALTH SERV RES, V42, P1443, DOI 10.1111/j.1475-6773.2006.00669.x
   Huang SQ, 2011, HYPERTENS RES, V34, P503, DOI 10.1038/hr.2010.265
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Leech NL, 2010, J COUNS DEV, V88, P61, DOI 10.1002/j.1556-6678.2010.tb00151.x
   Lewis SJ, 2008, INT J CLIN PRACT, V62, P1168, DOI 10.1111/j.1742-1241.2008.01770.x
   Lo SWS, 2016, HEALTH EDUC J, V75, P589, DOI 10.1177/0017896915608205
   McGinty HL, 2012, PSYCHO-ONCOLOGY, V21, P203, DOI 10.1002/pon.1883
   Noar SM, 2008, PREV MED, V46, P275, DOI 10.1016/j.ypmed.2007.08.001
   Noar SM, 2005, HEALTH EDUC RES, V20, P275, DOI 10.1093/her/cyg113
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Onwuegbuzie AJ, 2007, QUAL REP, V12, P281
   Patnaik JL, 2011, BREAST CANCER RES, V13, DOI 10.1186/bcr2901
   Pavelka JC, 2006, CANCER-AM CANCER SOC, V107, P1520, DOI 10.1002/cncr.22194
   Reis N, 2010, EUR J ONCOL NURS, V14, P137, DOI 10.1016/j.ejon.2009.09.004
   Rosato V, 2011, ANN ONCOL, V22, P884, DOI 10.1093/annonc/mdq464
   Shikanov S, 2012, PROSTATE CANCER P D, V15, P106, DOI 10.1038/pcan.2011.55
   Shinn EH, 2007, UROLOGY, V69, P748, DOI 10.1016/j.urology.2006.12.022
   Simard S, 2013, J CANCER SURVIV, V7, P300, DOI 10.1007/s11764-013-0272-z
   Sperling LS, 2015, J AM COLL CARDIOL, V66, P1050, DOI 10.1016/j.jacc.2015.06.1328
   Steinherz L, 2008, J AM COLL CARDIOL, V51, P1235, DOI 10.1016/j.jacc.2007.11.060
   Wan LH, 2014, J CARDIOVASC NURS, V29, pE1, DOI 10.1097/JCN.0b013e31827f0ab5
   Weaver KE, 2013, J CANCER SURVIV, V7, P253, DOI 10.1007/s11764-013-0267-9
   Wolin KY, 2011, J INTERN MED, V269, P85, DOI 10.1111/j.1365-2796.2010.02295.x
   Wu FT, 2014, J CLIN DENSITOM, V17, P466, DOI 10.1016/j.jocd.2014.07.008
   Yahia N, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-111
   Youlden D, 2005, CANC SURVIVAL QUEENS
NR 42
TC 4
Z9 4
U1 0
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0162-220X
EI 1538-9804
J9 CANCER NURS
JI Cancer Nurs.
PD MAR-APR
PY 2019
VL 42
IS 2
BP E48
EP E60
DI 10.1097/NCC.0000000000000598
PG 13
WC Oncology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Nursing
GA HN7VG
UT WOS:000460400000006
PM 29734256
DA 2025-06-11
ER

PT J
AU Donatelli, F
   Cavagna, P
   Di Dedda, G
   Catenacci, A
   Di Nicola, M
   Lorini, L
   Fumagalli, R
   Carli, F
AF Donatelli, F.
   Cavagna, P.
   Di Dedda, G.
   Catenacci, A.
   Di Nicola, M.
   Lorini, L.
   Fumagalli, R.
   Carli, F.
TI Correlation between pre-operative metabolic syndrome and persistent
   blood glucose elevation during cardiac surgery in non-diabetic patients
SO ACTA ANAESTHESIOLOGICA SCANDINAVICA
LA English
DT Article
DE metabolic syndrome; cardiopulmonary bypass
ID HOMEOSTASIS MODEL ASSESSMENT; INTENSIVE INSULIN THERAPY; CARDIOPULMONARY
   BYPASS; DIABETIC-PATIENTS; GLYCEMIC CONTROL; RESISTANCE; REMIFENTANIL;
   INFLAMMATION; RESPONSES; STRESS
AB Background: Cardiopulmonary-bypass (CPB) induces hyperglycemia. There is growing evidence that perioperative maintenance of blood glucose within the physiological range improves patients' outcome. Nevertheless, perioperative normoglycemia is often difficult to achieve during surgery with CPB and the response to insulin infusion is characterized by a considerable variability. The aim of this study was to determine to what extent the presence of pre-operative metabolic syndrome (MS) influences the blood glucose and insulin response during cardiac surgery.
   Methods: Forty-five patients scheduled for elective cardiac surgery were screened for the presence of MS according to the International Diabetes Federation definition. Patients were then assigned to two groups: those with metabolic syndrome (MSP) and those without (control). During surgery, blood glucose levels were measured in all patients and hyperglycemia was treated with a standard protocol of continuous insulin infusion.
   Results: The mean blood glucose levels during CPB increased only in the MSP group (P < 0.001). Mean blood glucose in control patients did not increase during CPB (P = 0.4). Patients with MS received 13.3 +/- 8.4 IU of insulin during CPB, while the control group did not require insulin treatment (P < 0.001). Forty percent of patients in the control group and 100% of those in the MSP group developed post-operative insulin resistance. C-reactive protein was higher in the MSP group before, during and at 48 h after surgery.
   Conclusions: The mean blood glucose levels during CPB increased only in patients with MS, while they remained unchanged in patients in the control group.
C1 [Donatelli, F.; Cavagna, P.; Di Dedda, G.; Catenacci, A.; Di Nicola, M.; Lorini, L.] Osped Riuniti Bergamo, Dept Anesthesia, I-24100 Bergamo, Italy.
   [Di Nicola, M.] Univ G dAnnunzio, Dipartimento Stat, Chieti, Italy.
   [Fumagalli, R.] Univ Milan, Bicocca, Italy.
   [Carli, F.] McGill Univ, Dept Anesthesia, Montreal, PQ, Canada.
C3 Ospedali Riuniti di Bergamo; G d'Annunzio University of Chieti-Pescara;
   University of Milan; McGill University
RP Donatelli, F (corresponding author), Osped Riuniti Bergamo, Dept Anesthesia, Largo Barozzi 3, I-24100 Bergamo, Italy.
EM fdonatelli@inwind.it
RI Donatelli, Francesco/G-9311-2012; Fumagalli, Roberto/AAB-9746-2019; Di
   Nicola, Marco/HKP-2003-2023
OI lorini, luca ferdinando/0000-0002-2711-3377; FUMAGALLI,
   ROBERTO/0000-0003-0398-1329; DI NICOLA, MARTA/0000-0003-1748-1931
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Anderson RE, 2000, ANN THORAC SURG, V69, P847, DOI 10.1016/S0003-4975(99)01526-X
   BONORA E, 1986, DIABETES METAB, V12, P143
   Bonora E, 2000, DIABETES CARE, V23, P57, DOI 10.2337/diacare.23.1.57
   Chaney MA, 1999, ANESTH ANALG, V89, P1091, DOI 10.1213/00000539-199911000-00004
   de Rekeneire N, 2006, DIABETES CARE, V29, P1902, DOI 10.2337/dc05-2327
   Donatelli F, 2007, ANESTH ANALG, V104, P1587, DOI 10.1213/01.ane.0000261506.48816.5c
   Emoto M, 1999, DIABETES CARE, V22, P818, DOI 10.2337/diacare.22.5.818
   Esposito K, 2005, INT J IMPOT RES, V17, P224, DOI 10.1038/sj.ijir.3901310
   Esposito K, 2004, NUTR METAB CARDIOVAS, V14, P228, DOI 10.1016/S0939-4753(04)80048-6
   Furnary AP, 1999, ANN THORAC SURG, V67, P352, DOI 10.1016/S0003-4975(99)00014-4
   Gandhi GY, 2007, ANN INTERN MED, V146, P233, DOI 10.7326/0003-4819-146-4-200702200-00002
   Groop L, 2000, BRIT J NUTR, V83, pS39
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Hanley AJG, 2002, DIABETES CARE, V25, P1177, DOI 10.2337/diacare.25.7.1177
   KERCHNER J, 1980, AM J HOSP PHARM, V37, P1323, DOI 10.1093/ajhp/37.10.1323
   KUNTSCHEN FR, 1985, J THORAC CARDIOV SUR, V89, P97
   KUNTSCHEN FR, 1986, J THORAC CARDIOV SUR, V91, P451
   Lazar HL, 2004, CIRCULATION, V109, P1497, DOI 10.1161/01.CIR.0000121747.71054.79
   LEHOT JJ, 1992, CHEST, V102, P106, DOI 10.1378/chest.102.1.106
   Lidfeldt J, 2003, DIABETES OBES METAB, V5, P106, DOI 10.1046/j.1463-1326.2003.00250.x
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   MIZOCK BA, 1995, AM J MED, V98, P75, DOI 10.1016/S0002-9343(99)80083-7
   Myles PS, 2002, ANESTH ANALG, V95, P805, DOI 10.1097/00000539-200210000-00004
   Ouattara A, 2005, ANESTHESIOLOGY, V103, P687, DOI 10.1097/00000542-200510000-00006
   Paparella D, 2002, EUR J CARDIO-THORAC, V21, P232, DOI 10.1016/S1010-7940(01)01099-5
   Prasad AA, 2007, J CARDIOTHOR VASC AN, V21, P843, DOI 10.1053/j.jvca.2006.12.014
   Rassias AJ, 2002, ANESTH ANALG, V94, P1113, DOI 10.1097/00000539-200205000-00010
   Sekiguchi M, 2004, AM J CARDIOL, V93, P920, DOI 10.1016/j.amjcard.2003.12.036
   Shann KG, 2006, J THORAC CARDIOV SUR, V132, P283, DOI 10.1016/j.jtcvs.2006.03.027
   Smith CE, 2005, J CARDIOTHOR VASC AN, V19, P201, DOI 10.1053/j.jvca.2005.01.032
   Steinlechner B, 2007, BRIT J ANAESTH, V98, P598, DOI 10.1093/bja/aem069
   Van den Berghe G, 2006, NEW ENGL J MED, V354, P449, DOI 10.1056/NEJMoa052521
   Van den Berghe G, 2001, NEW ENGL J MED, V345, P1359, DOI 10.1056/NEJMoa011300
   Weale NK, 2004, BRIT J ANAESTH, V92, P187, DOI 10.1093/bja/aeh038
NR 35
TC 22
Z9 25
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-5172
EI 1399-6576
J9 ACTA ANAESTH SCAND
JI Acta Anaesthesiol. Scand.
PD SEP
PY 2008
VL 52
IS 8
BP 1103
EP 1110
DI 10.1111/j.1399-6576.2008.01693.x
PG 8
WC Anesthesiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology
GA 339QX
UT WOS:000258593200012
PM 18840111
DA 2025-06-11
ER

PT J
AU Wang, J
   Wu, DC
   Guo, H
   Li, MX
AF Wang, Juan
   Wu, Daichao
   Guo, Hui
   Li, Meixiang
TI Hyperandrogenemia and insulin resistance: The chief culprit of
   polycystic ovary syndrome
SO LIFE SCIENCES
LA English
DT Review
DE PCOS; Hyperandrogenemia; Insulin resistance; Advanced glycosylation end
   products; Endocrine disrupting chemicals
ID GRANULOSA-CELLS; SYNDROME PCOS; DEHYDROEPIANDROSTERONE-SULFATE;
   METABOLIC SYNDROME; GENETIC-VARIATION; OXIDATIVE STRESS; WOMEN;
   EXPRESSION; ADIPONECTIN; ANDROGEN
AB Polycystic ovary syndrome (PCOS) is one of the most common systemic reproductive endocrine diseases, which has a variety of effects on a woman's health. Because of the involvement of multiple pathways and the lack of common clues, PCOS demonstrates multifactorial properties and heterogeneity of symptoms. Recent studies have demonstrated that the core etiology and primary endocrine characteristics of PCOS are hyperandrogenemia (HA) and insulin resistance (IR). HA and IR are the main causes of PCOS and they can interplay each other in the occurrence and development of PCOS. Just because of this, the study about the effects of HA and IR on pathophysiology of various related symptoms of PCOS is very important to understand the pathogenesis of PCOS. This paper reviews the main symptoms of PCOS, including neuroendocrine disorders, reproductive processes, dyslipidemia, obesity, hypertension, nonalcoholic fatty liver disease (NAFLD), and sleep disordered breathing, which seriously affect the physical and mental health of PCOS women. The increasing knowledge of the development pattern of HA and IR in PCOS suggests that changes in diet and lifestyle, and the discovery of potential therapeutic agents may improve PCOS. However, further studies are needed to clarify the mutual influence and relation of HA and IR in development of PCOS. This review provides an overview of the current knowledge about the effects of HA and IR on PCOS.
C1 [Wang, Juan; Wu, Daichao; Guo, Hui; Li, Meixiang] Univ South China, Inst Clin Anat & Reprod Med, Dept Histol & Embryol, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
C3 University of South China
RP Li, MX (corresponding author), Univ South China, Inst Clin Anat & Reprod Med, Dept Histol & Embryol, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
EM 430000146116@usc.edu.cn
RI li, liangwei/JGM-2459-2023
FU Department of Science and Technology of Hunan province and Hengyang
FX We wish to thank the Department of Science and Technology of Hunan
   province and Hengyang for their partial financial support of this study.
CR Abbott DH, 2019, EXPERT REV ENDOCRINO, V14, P131, DOI 10.1080/17446651.2019.1576522
   Anagnostis P, 2018, METABOLISM, V86, P33, DOI 10.1016/j.metabol.2017.09.016
   Anderson AD, 2014, SEMIN REPROD MED, V32, P202, DOI 10.1055/s-0034-1371092
   Angelidis G, 2013, REPROD SCI, V20, P872, DOI 10.1177/1933719112468954
   [Anonymous], PLOS ONE
   [Anonymous], INDIAN J DERMATOL
   Artimani T, 2016, J ASSIST REPROD GEN, V33, P101, DOI 10.1007/s10815-015-0620-1
   Azziz R, 2006, J CLIN ENDOCR METAB, V91, P4237, DOI 10.1210/jc.2006-0178
   Bani Mohammad Majid, 2017, Asian Pac J Cancer Prev, V18, P17
   Bannigida DM, 2020, ARCH PHYSIOL BIOCHEM, V126, P183, DOI 10.1080/13813455.2018.1499120
   Bañuls C, 2017, METABOLISM, V71, P153, DOI 10.1016/j.metabol.2017.02.012
   Benrick A, 2017, P NATL ACAD SCI USA, V114, pE7187, DOI 10.1073/pnas.1708854114
   Butts SF, 2019, J CLIN ENDOCR METAB, V104, P369, DOI 10.1210/jc.2018-00750
   Carbunaru G, 2004, J CLIN ENDOCR METAB, V89, P783, DOI 10.1210/jc.2003-030934
   Chen C, 2009, MOL HUM REPROD, V15, P459, DOI 10.1093/molehr/gap035
   Chua AK, 2012, MOL HUM REPROD, V18, P320, DOI 10.1093/molehr/gas002
   Corbould A, 2005, AM J PHYSIOL-ENDOC M, V288, pE1047, DOI 10.1152/ajpendo.00361.2004
   Cui Wei, 2011, Zhongguo Zhen Jiu, V31, P687
   Demacopulo B, 2019, MOL CELL ENDOCRINOL, V483, P64, DOI 10.1016/j.mce.2019.01.006
   Diamanti-Kandarakis E, 2007, TRENDS ENDOCRIN MET, V18, P280, DOI 10.1016/j.tem.2007.07.004
   Diamanti-Kandarakis E, 2006, TRENDS MOL MED, V12, P324, DOI 10.1016/j.molmed.2006.05.006
   Diav-Citrin O, 2018, REPROD TOXICOL, V80, P85, DOI 10.1016/j.reprotox.2018.05.007
   Dokras A, 2016, J CLIN ENDOCR METAB, V101, P2966, DOI 10.1210/jc.2016-1896
   DOR J, 1980, AM J OBSTET GYNECOL, V136, P102, DOI 10.1016/0002-9378(80)90574-8
   Dumesic DA, 2015, ENDOCR REV, V36, P487, DOI 10.1210/er.2015-1018
   Endoh A, 1996, J CLIN ENDOCR METAB, V81, P3558, DOI 10.1210/jc.81.10.3558
   Erensoy H, 2019, GYNECOL ENDOCRINOL, V35, P72, DOI 10.1080/09513590.2018.1498476
   Facchinetti F, 2019, GYNECOL ENDOCRINOL, V35, P198, DOI 10.1080/09513590.2018.1540578
   Faure M, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00675
   Fauser BCJM, 2012, FERTIL STERIL, V97, P28, DOI 10.1016/j.fertnstert.2011.09.024
   Fernandez RC, 2018, NAT SCI SLEEP, V10, P45, DOI 10.2147/NSS.S127475
   Filippou P, 2017, HUM REPROD UPDATE, V23, P421, DOI 10.1093/humupd/dmx013
   Garcia V, 2015, HORM METAB RES, V47, P901, DOI 10.1055/s-0035-1555806
   Garg D, 2016, INT J ENDOCRINOL, V2016, DOI 10.1155/2016/1979654
   Gonzalez CD, 2019, CURR CLIN PHARMACOL, V14, P54, DOI 10.2174/1574884714666181224151116
   Hafez M, 2019, J PEDIATR ENDOCR MET, V32, P461, DOI 10.1515/jpem-2018-0430
   Helseth R, 2014, EUR J ENDOCRINOL, V170, P769, DOI 10.1530/EJE-13-0859
   Hennebert O, 2007, J STEROID BIOCHEM, V104, P326, DOI 10.1016/j.jsbmb.2007.03.026
   Hewlett M, 2017, REPROD SCI, V24, P19, DOI 10.1177/1933719116654992
   Hu JP, 2011, AM J MED SCI, V342, P38, DOI 10.1097/MAJ.0b013e31820f835b
   Hyer S, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19071954
   Irani M, 2014, J CLIN ENDOCR METAB, V99, pE886, DOI 10.1210/jc.2013-4374
   Jones MR, 2007, MOL HUM REPROD, V13, P237, DOI 10.1093/molehr/gal120
   Jones MR, 2015, PLOS GENET, V11, DOI 10.1371/journal.pgen.1005455
   Karjula S, 2017, J CLIN ENDOCR METAB, V102, P1861, DOI 10.1210/jc.2016-3863
   Kelley CE, 2014, WORLD J GASTROENTERO, V20, P14172, DOI 10.3748/wjg.v20.i39.14172
   Laganà AS, 2016, INT J ENDOCRINOL, V2016, DOI 10.1155/2016/6306410
   Lai Mao-Hua, 2016, Zhen Ci Yan Jiu, V41, P435
   Lautatzis ME, 2013, METABOLISM, V62, P1522, DOI 10.1016/j.metabol.2013.06.006
   Legro RS, 2013, J CLIN ENDOCR METAB, V98, P4565, DOI 10.1210/jc.2013-2350
   Lerchbaum E, 2012, FERTIL STERIL, V98, P1318, DOI 10.1016/j.fertnstert.2012.07.1057
   Li C, 2011, MOL HUM REPROD, V17, P193, DOI 10.1093/molehr/gaq087
   Li J, 2018, HUM REPROD, V33, P145
   Li QL, 2016, HUM REPROD, V31, P2150, DOI 10.1093/humrep/dew162
   Li Y, 2019, LIFE SCI, V228, P167, DOI 10.1016/j.lfs.2019.04.046
   Liu XY, 2019, FERTIL STERIL, V111, P157, DOI 10.1016/j.fertnstert.2018.09.022
   Louwers YV, 2013, J CLIN ENDOCR METAB, V98, P3848, DOI 10.1210/jc.2013-1976
   Loverro G, 2002, GYNECOL ENDOCRINOL, V16, P217, DOI 10.1080/713603060
   Lu C, 2018, NEUROENDOCRINOLOGY, V107, P60, DOI 10.1159/000488110
   Luque-Ramírez M, 2016, CURR PHARM DESIGN, V22, P5588, DOI 10.2174/1381612822666160720150625
   Lutz SZ, 2016, J CLIN ENDOCR METAB, V101, P4743, DOI 10.1210/jc.2016-2498
   McAllister JM, 2015, TRENDS ENDOCRIN MET, V26, P118, DOI 10.1016/j.tem.2014.12.004
   McNelis JC, 2013, AM J PHYSIOL-ENDOC M, V305, pE1134, DOI 10.1152/ajpendo.00314.2012
   Meier RK, 2018, NURS CLIN N AM, V53, P407, DOI 10.1016/j.cnur.2018.04.008
   Mereness AL, 2015, BIOL REPROD, V92, DOI 10.1095/biolreprod.114.126409
   Merhi Z, 2019, TRENDS ENDOCRIN MET, V30, P150, DOI 10.1016/j.tem.2019.01.005
   Miller WL, 2015, MOL CELL ENDOCRINOL, V408, P99, DOI 10.1016/j.mce.2014.09.010
   Miller WL, 2011, ENDOCR REV, V32, P81, DOI 10.1210/er.2010-0013
   Moran LJ, 2015, TRENDS ENDOCRIN MET, V26, P136, DOI 10.1016/j.tem.2014.12.003
   Mykhalchenko K, 2017, EXPERT REV MOL DIAGN, V17, P723, DOI 10.1080/14737159.2017.1340833
   Nicol LE, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0106527
   Orio F, 2014, NAT REV ENDOCRINOL, V10, P130, DOI 10.1038/nrendo.2013.248
   Oróstica L, 2016, CURR PHARM DESIGN, V22, P5614, DOI 10.2174/1381612822666160810111528
   Palioura E, 2015, REV ENDOCR METAB DIS, V16, P365, DOI 10.1007/s11154-016-9326-7
   Patel R, 2018, ARCH MED RES, V49, P154, DOI 10.1016/j.arcmed.2018.08.001
   Qu F, 2010, HUM REPROD, V25, P1441, DOI 10.1093/humrep/deq078
   Roe A, 2014, J CLIN ENDOCR METAB, V99, pE841, DOI 10.1210/jc.2013-3918
   Rosenfield RL, 2016, ENDOCR REV, V37, P467, DOI 10.1210/er.2015-1104
   Ryan GE, 2018, ENDOCRINOLOGY, V159, P1734, DOI 10.1210/en.2017-03218
   Sadrzadeh S, 2016, GYNECOL ENDOCRINOL, V32, P856, DOI 10.1080/09513590.2016.1186632
   Sagvekar P, 2017, J CLIN ENDOCR METAB, V102, P1396, DOI 10.1210/jc.2016-2645
   Sam S, 2017, DIABETOLOGIA, V60, P1656, DOI 10.1007/s00125-017-4306-3
   Saponaro S, 2007, J STEROID BIOCHEM, V103, P129, DOI 10.1016/j.jsbmb.2006.08.003
   Scherneck S, 2018, REPROD TOXICOL, V81, P79, DOI 10.1016/j.reprotox.2018.07.004
   Schmidt J, 2014, MOL HUM REPROD, V20, P49, DOI 10.1093/molehr/gat051
   Seow KM, 2007, HUM REPROD, V22, P1003, DOI 10.1093/humrep/del466
   Shah D, 2016, CLIMACTERIC, V19, P7, DOI 10.3109/13697137.2015.1116505
   Shokrpour M, 2019, GYNECOL ENDOCRINOL, V35, P406, DOI 10.1080/09513590.2018.1540570
   Sieminska L, 2004, J ENDOCRINOL INVEST, V27, P528, DOI 10.1007/BF03347474
   Sjaarda LA, 2014, J CLIN ENDOCR METAB, V99, P2208, DOI 10.1210/jc.2013-3781
   Sorensen AE, 2016, CHEM-BIOL INTERACT, V259, P8, DOI 10.1016/j.cbi.2016.06.008
   Spinedi E, 2018, INT J ENDOCRINOL, V2018, DOI 10.1155/2018/1349868
   Spritzer PM, 2016, CURR PHARM DESIGN, V22, P5603, DOI 10.2174/1381612822666160720151243
   Stener-Victorin E, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-024733
   Su Y, 2017, ENDOCR J, V64, P613, DOI 10.1507/endocrj.EJ16-0494
   Szydlarska D, 2017, ADV CLIN EXP MED, V26, P555, DOI 10.17219/acem/61987
   Takemura Y, 2006, ENDOCRINOLOGY, V147, P3203, DOI 10.1210/en.2005-1510
   Tao T, 2018, BMC ENDOCR DISORD, V18, DOI 10.1186/s12902-018-0243-5
   Tay CT, 2018, CLIN ENDOCRINOL, V89, P535, DOI 10.1111/cen.13753
   Thathapudi S, 2015, GENET TEST MOL BIOMA, V19, P128, DOI 10.1089/gtmb.2014.0249
   Underdal MO, 2018, J CLIN ENDOCR METAB, V103, P2408, DOI 10.1210/jc.2018-00485
   van Weelden W, 2018, DIABETES THER, V9, P1811, DOI 10.1007/s13300-018-0479-0
   Wang H, 2011, MOL HUM REPROD, V17, P386, DOI 10.1093/molehr/gar007
   Wang MJ, 2019, METABOLISM, V94, P47, DOI 10.1016/j.metabol.2019.02.002
   Wang R, 2017, HUM REPROD, V32, P261, DOI 10.1093/humrep/dew287
   Wang R, 2012, MOL HUM REPROD, V18, P498, DOI 10.1093/molehr/gas024
   Wikiera Beata, 2017, Pediatr Endocrinol Diabetes Metab, V23, P204, DOI 10.18544/PEDM-23.04.0094
   Xiao S, 2014, J CLIN ENDOCR METAB, V99, pE1015, DOI 10.1210/jc.2013-4177
   Yeganeh LM, 2018, J OBSTET GYNAECOL, V38, P241, DOI 10.1080/01443615.2017.1346593
   Yuan XX, 2016, P NATL ACAD SCI USA, V113, P2708, DOI 10.1073/pnas.1523236113
   Zhang N, 2017, GYNECOL ENDOCRINOL, V33, P113, DOI 10.1080/09513590.2016.1214259
   Zhao DM, 2018, MOL MED REP, V17, P414, DOI 10.3892/mmr.2017.7890
   Zhao Y, 2015, J CLIN ENDOCR METAB, V100, P201, DOI 10.1210/jc.2014-2419
NR 113
TC 203
Z9 223
U1 2
U2 45
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD NOV 1
PY 2019
VL 236
AR 116940
DI 10.1016/j.lfs.2019.116940
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA JG8TF
UT WOS:000492349800010
PM 31604107
DA 2025-06-11
ER

PT J
AU Scoville, DK
   Li, CYF
   Wang, DF
   Dempsey, JL
   Raftery, D
   Mani, S
   Gu, HW
   Cui, JLY
AF Scoville, David K.
   Li, Cindy Yanfei
   Wang, Dongfang
   Dempsey, Joseph L.
   Raftery, Daniel
   Mani, Sridhar
   Gu, Haiwei
   Cui, Julia Yue
TI Polybrominated Diphenyl Ethers and Gut Microbiome Modulate Metabolic
   Syndrome-Related Aqueous Metabolites in Mice
SO DRUG METABOLISM AND DISPOSITION
LA English
DT Article
ID PERSISTENT ORGANIC POLLUTANTS; PREGNANE-X-RECEPTOR; COLORECTAL-CANCER;
   FLAME-RETARDANTS; DIABETES-MELLITUS; OXIDATIVE STRESS; AMINO-ACIDS;
   OH-PBDES; SERUM; INFLAMMATION
AB Polybrominated diphenyl ethers (PBDEs) are persistent environmental toxicants associated with increased risk for metabolic syndrome. Intermediary metabolism is influenced by the intestinal microbiome. To test the hypothesis that PBDEs reduce host-beneficial intermediary metabolites in an intestinal microbiome-dependent manner, 9-week old male conventional (CV) and germ-free (GF) C57BU6 mice were orally gavaged once daily with vehicle, BDE-47, or BDE-99 (100 mu mol/kg) for 4 days. Intestinal microbiome (16S rDNA sequencing), liver transcriptome (RNA-Seq), and intermediary metabolites in serum, liver, as well as small and large intestinal contents (SIC and LIC; LC-MS) were examined. Changes in intermediary metabolite abundances in serum, liver, and SIC, were observed under basal conditions (CV vs. GF mice) and by PBDE exposure. PBDEs altered the largest number of metabolites in the LIC; most were regulated by PBDEs in GF conditions. Importantly, intestinal microbiome was necessary for PBDE-mediated decreases in branched-chain and aromatic amino acid metabolites, including 3-indolepropionic acid, a tryptophan metabolite recently shown to be protective against inflammation and diabetes. Gene-metabolite networks revealed a positive association between the hepatic glycan synthesis gene alpha-1,6-mannosyltransferase (A1g12) mRNA and mannose, which are important for protein glycosylation. Glycome changes have been observed in patients with metabolic syndrome. In LIC of CV mice, 23 bacterial taxa were regulated by PBDEs. Correlations of certain taxa with distinct serum metabolites further highlight a modulatory role of the microbiome in mediating PBDE effects. In summary, PBDEs impact intermediary metabolism in an intestinal microbiome-dependent manner, suggesting that dysbiosis may contribute to PBDE-mediated toxicities that include metabolic syndrome.
C1 [Scoville, David K.; Li, Cindy Yanfei; Dempsey, Joseph L.; Cui, Julia Yue] Univ Washington, Dept Environm & Occupat Hlth Sci, 4225 Roosevelt Way NE, Seattle, WA 98105 USA.
   [Wang, Dongfang; Raftery, Daniel] Univ Washington, Northwest Metabol Res Ctr, Dept Anesthesiol & Pain Med, Seattle, WA 98105 USA.
   [Wang, Dongfang] Peking Univ, Sch Publ Hlth, Dept Lab Sci & Technol, Beijing, Peoples R China.
   [Mani, Sridhar] Albert Einstein Coll Med, Bronx, NY 10467 USA.
   [Gu, Haiwei] Arizona State Univ, Coll Hlth Solut, Sch Nutr & Hlth Promot, Arizona Metabol Lab, Phoenix, AZ 85004 USA.
C3 University of Washington; University of Washington Seattle; University
   of Washington; University of Washington Seattle; Peking University;
   Yeshiva University; Montefiore Medical Center; Albert Einstein College
   of Medicine; Arizona State University; Arizona State University-Downtown
   Phoenix
RP Cui, JLY (corresponding author), Univ Washington, Dept Environm & Occupat Hlth Sci, 4225 Roosevelt Way NE, Seattle, WA 98105 USA.; Gu, HW (corresponding author), Arizona State Univ, Coll Hlth Solut, Sch Nutr & Hlth Promot, Arizona Metabol Lab, Phoenix, AZ 85004 USA.
EM haiweigu@asu.edu; juliacui@uw.edu
FU National Institutes of Health [R01 GM111381, R01 ES030197, R01
   ES025708]; University of Washington Center for Exposures, Diseases,
   Genomics, and Environment [P30 ES0007033]; Sheldon Murphy Endowment
FX This work was supported by the National Institutes of Health [Grants R01
   GM111381, R01 ES030197, R01 ES025708], the University of Washington
   Center for Exposures, Diseases, Genomics, and Environment [P30
   ES0007033], and the Sheldon Murphy Endowment.
CR Abildgaard A, 2018, ARCH PHYSIOL BIOCHEM, V124, P306, DOI 10.1080/13813455.2017.1398262
   Aebi M, 2013, BBA-MOL CELL RES, V1833, P2430, DOI 10.1016/j.bbamcr.2013.04.001
   [Anonymous], SIGN NEW US TEST RUL
   [Anonymous], J GLYCOMICS LIPIDOMI
   Arner P, 2014, TRENDS ENDOCRIN MET, V25, P255, DOI 10.1016/j.tem.2014.03.002
   ATSDR, 2017, TOX PROF POL DIPH ET
   Barton S, 2015, FOOD FUNCT, V6, P2949, DOI [10.1039/c5fo00287g, 10.1039/C5FO00287G]
   Bezares-Cruz J, 2004, ENVIRON SCI TECHNOL, V38, P4149, DOI 10.1021/es049608o
   Bondy GS, 2013, ENVIRON TOXICOL, V28, P215, DOI 10.1002/tox.20713
   Burda P, 1999, BBA-GEN SUBJECTS, V1426, P239, DOI 10.1016/S0304-4165(98)00127-5
   Carroll PA, 2015, CANCER CELL, V27, P271, DOI 10.1016/j.ccell.2014.11.024
   Cervantes-Barragan L, 2017, SCIENCE, V357, P806, DOI 10.1126/science.aah5825
   Cheng J, 2012, TRENDS PHARMACOL SCI, V33, P323, DOI 10.1016/j.tips.2012.03.003
   Chong J, 2018, NUCLEIC ACIDS RES, V46, pW486, DOI 10.1093/nar/gky310
   Cole JT, 2015, NUTR HEALTH SER, P13, DOI 10.1007/978-1-4939-1923-9_2
   Cowell WJ, 2019, J EXPO SCI ENV EPID, V29, P49, DOI 10.1038/s41370-018-0031-3
   Cowens KR, 2015, J TOXICOL ENV HEAL A, V78, P1437, DOI 10.1080/15287394.2015.1098580
   de Mello VD, 2017, SCI REP-UK, V7, DOI 10.1038/srep46337
   Deng LL, 2016, ANAL CHEM, V88, P7975, DOI 10.1021/acs.analchem.6b00885
   Dodd D, 2017, NATURE, V551, P648, DOI 10.1038/nature24661
   Domingueti CP, 2016, J DIABETES COMPLICAT, V30, P738, DOI 10.1016/j.jdiacomp.2015.12.018
   Donath MY, 2011, NAT REV IMMUNOL, V11, P98, DOI 10.1038/nri2925
   Dunnick JK, 2012, TOXICOL PATHOL, V40, P93, DOI 10.1177/0192623311429973
   Eslami B, 2016, ENVIRON RES, V151, P706, DOI 10.1016/j.envres.2016.09.002
   European Union (EU), 2001, EUR UN RISK ASS REP
   Farah R, 2008, CARDIOVASC DIABETOL, V7, DOI 10.1186/1475-2840-7-20
   Girousse A, 2013, PLOS BIOL, V11, DOI 10.1371/journal.pbio.1001485
   Goldfine AB, 2011, CLIN CHEM, V57, P162, DOI 10.1373/clinchem.2010.148833
   Gu HW, 2016, ANGEW CHEM INT EDIT, V55, P15646, DOI 10.1002/anie.201609236
   Gu HW, 2015, ANAL CHEM, V87, P12355, DOI 10.1021/acs.analchem.5b03812
   Heimann E, 2016, ADIPOCYTE, V5, P359, DOI 10.1080/21623945.2016.1252011
   Heimann E, 2015, ADIPOCYTE, V4, P81, DOI 10.4161/21623945.2014.960694
   Helaleh M, 2018, CHEMOSPHERE, V209, P268, DOI 10.1016/j.chemosphere.2018.06.108
   Hites RA, 2004, ENVIRON SCI TECHNOL, V38, P945, DOI 10.1021/es035082g
   Hojs R, 2016, NEPHRON, V133, P159, DOI 10.1159/000447434
   Hoppe AA, 2007, OBESITY, V15, P2942, DOI 10.1038/oby.2007.351
   Hothorn T, 2008, BIOMETRICAL J, V50, P346, DOI 10.1002/bimj.200810425
   Hurley S, 2017, ENVIRON SCI TECHNOL, V51, P4697, DOI 10.1021/acs.est.7b00565
   Imm P, 2009, ENVIRON HEALTH PERSP, V117, P1890, DOI 10.1289/ehp.0900839
   Kanehisa M, 2000, NUCLEIC ACIDS RES, V28, P27, DOI 10.1093/nar/28.1.27
   Kanehisa M, 2017, NUCLEIC ACIDS RES, V45, pD353, DOI 10.1093/nar/gkw1092
   Kanehisa M, 2016, NUCLEIC ACIDS RES, V44, pD457, DOI 10.1093/nar/gkv1070
   Karandrea S, 2017, ENVIRON TOXICOL PHAR, V56, P29, DOI 10.1016/j.etap.2017.08.030
   Koike E, 2014, TOXICOL IN VITRO, V28, P327, DOI 10.1016/j.tiv.2013.10.014
   Krumm EA, 2018, TOXICOL SCI, V162, P212, DOI 10.1093/toxsci/kfx238
   La Guardia MJ, 2006, ENVIRON SCI TECHNOL, V40, P6247, DOI 10.1021/es060630m
   Li CY, 2018, DRUG METAB DISPOS, V46, P1226, DOI 10.1124/dmd.118.081547
   Li CYF, 2017, DRUG METAB DISPOS, V45, P1197, DOI 10.1124/dmd.117.077024
   LIEBICH HM, 1984, J CHROMATOGR, V309, P225, DOI 10.1016/0378-4347(84)80031-6
   Liu XB, 2012, MEDIAT INFLAMM, V2012, DOI 10.1155/2012/692467
   Lu JP, 2011, J PROTEOME RES, V10, P4959, DOI 10.1021/pr2004067
   Lv QY, 2015, CHEMOSPHERE, V120, P621, DOI 10.1016/j.chemosphere.2014.08.029
   Lynch CJ, 2014, NAT REV ENDOCRINOL, V10, P723, DOI 10.1038/nrendo.2014.171
   Ma WL, 2013, ENVIRON SCI TECHNOL, V47, P8015, DOI 10.1021/es401857v
   Marchitti SA, 2017, ENVIRON HEALTH PERSP, V125, P706, DOI 10.1289/EHP332
   Martin PA, 2007, ENVIRON TOXICOL CHEM, V26, P988, DOI 10.1897/06-246R.1
   Mauvais-Jarvis F, 2013, ENDOCR REV, V34, P309, DOI 10.1210/er.2012-1055
   McConnachie LA, 2007, TOXICOL SCI, V99, P628, DOI 10.1093/toxsci/kfm165
   McIntyre Rebecca L, 2015, BMC Obes, V2, P3, DOI 10.1186/s40608-014-0031-3
   Morigny P, 2016, BIOCHIMIE, V125, P259, DOI 10.1016/j.biochi.2015.10.024
   Nicholson JK, 2012, SCIENCE, V336, P1262, DOI 10.1126/science.1223813
   Pacyniak EK, 2007, TOXICOL SCI, V97, P94, DOI 10.1093/toxsci/kfm025
   Parry E, 2018, CHEMOSPHERE, V195, P777, DOI 10.1016/j.chemosphere.2017.12.065
   Quan EM, 2008, MOL CELL, V32, P870, DOI 10.1016/j.molcel.2008.11.017
   R Core Team, 2017, R: A Language and Environment for Statistical Computing
   Reyes NL, 2015, P NATL ACAD SCI USA, V112, P424, DOI 10.1073/pnas.1413021112
   Ross David, 2018, Current Opinion in Toxicology, V7, P67, DOI 10.1016/j.cotox.2017.10.005
   Sanders JM, 2005, TOXICOL SCI, V88, P127, DOI 10.1093/toxsci/kfi288
   Schecter A, 2004, ENVIRON SCI TECHNOL, V38, P5306, DOI 10.1021/es0490830
   Schecter A, 2003, ENVIRON HEALTH PERSP, V111, P1723, DOI 10.1289/ehp.6466
   Schecter A, 2010, ENVIRON HEALTH PERSP, V118, P357, DOI 10.1289/ehp.0901345
   Scoville DK, 2019, TOXICOL APPL PHARM, V368, P55, DOI 10.1016/j.taap.2019.01.018
   Sjödin A, 2001, ENVIRON SCI TECHNOL, V35, P3830, DOI 10.1021/es010815n
   Smarr MM, 2016, SCI TOTAL ENVIRON, V551, P285, DOI 10.1016/j.scitotenv.2016.02.030
   Softeland L, 2011, AQUAT TOXICOL, V105, P246, DOI 10.1016/j.aquatox.2011.03.012
   Sood RF, 2015, WOUND REPAIR REGEN, V23, P423, DOI 10.1111/wrr.12299
   Sperber H, 2015, NAT CELL BIOL, V17, P1523, DOI 10.1038/ncb3264
   Sueyoshi T, 2014, TOXICOL SCI, V137, P292, DOI 10.1093/toxsci/kft243
   Thiel C, 2002, BIOCHEM J, V367, P195, DOI 10.1042/BJ20020794
   Trapnell C, 2010, NAT BIOTECHNOL, V28, P511, DOI 10.1038/nbt.1621
   Venkatesh M, 2014, IMMUNITY, V41, P296, DOI 10.1016/j.immuni.2014.06.014
   Vikram A, 2014, INT J ENDOCRINOL, V2014, DOI 10.1155/2014/679754
   Weldy CS, 2011, INHAL TOXICOL, V23, P724, DOI 10.3109/08958378.2011.608095
   White CC, 2003, ANAL BIOCHEM, V318, P175, DOI 10.1016/S0003-2697(03)00143-X
   Wickham H, 2009, USE R, P1, DOI 10.1007/978-0-387-98141-3_1
   Yisireyili M, 2017, NAGOYA J MED SCI, V79, P477, DOI 10.18999/nagjms.79.4.477
   ZARLING EJ, 1987, J LAB CLIN MED, V109, P566
   Zeng X, 2008, ENVIRON TOXICOL CHEM, V27, P2427, DOI 10.1897/07-570.1
   Zhang Z, 2016, SCI REP-UK, V6, DOI 10.1038/srep27854
   Zhang Z, 2013, ARCH TOXICOL, V87, P1557, DOI 10.1007/s00204-013-1059-8
   Zhou Jun, 2006, Nan Fang Yi Ke Da Xue Xue Bao, V26, P738
   Zhu JJ, 2015, ANAL BIOANAL CHEM, V407, P7857, DOI 10.1007/s00216-015-8984-8
   Zhu JJ, 2014, J PROTEOME RES, V13, P4120, DOI 10.1021/pr500494u
   Zota AR, 2013, ENVIRON SCI TECHNOL, V47, P11776, DOI 10.1021/es402204y
NR 94
TC 36
Z9 43
U1 1
U2 37
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0090-9556
EI 1521-009X
J9 DRUG METAB DISPOS
JI Drug Metab. Dispos.
PD AUG 1
PY 2019
VL 47
IS 8
BP 928
EP 940
DI 10.1124/dmd.119.086538
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IQ0JV
UT WOS:000480438000011
PM 31123037
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Nagase, M
AF Nagase, Miki
TI Activation of the aldosterone/mineralocorticoid receptor system in
   chronic kidney disease and metabolic syndrome
SO CLINICAL AND EXPERIMENTAL NEPHROLOGY
LA English
DT Article; Proceedings Paper
CT 52nd Annual Scientific Meeting of the Japanese-Society-of-Nephrology
CY JUN 03-05, 2009
CL Yokohama, JAPAN
SP Japanese Soc Nephrol
DE Proteinuria; Podocyte injury; Salt; Aldosterone-releasing factors; Rac1
ID HUMAN MINERALOCORTICOID RECEPTOR; HYPERTENSIVE-RATS; PRIMARY
   ALDOSTERONISM; DIABETIC-NEPHROPATHY; PLASMA-ALDOSTERONE; RENAL-DISEASE;
   MYOCARDIAL-INFARCTION; GLOMERULAR INJURY; ESTROGEN-RECEPTOR; TYPE-2
   DIABETES/
AB Recent clinical and experimental studies have shown that aldosterone is a potent inducer of proteinuria and that mineralocorticoid receptor (MR) antagonists confer efficient antiproteinuric effects. We identified glomerular epithelial cells (podocytes) as novel targets of aldosterone; activation of MR injures podocytes possibly via oxidative stress, resulting in disruption of glomerular filtration barrier, proteinuria, and progression of chronic kidney disease. We also demonstrated that SHR/cp, a rat model of metabolic syndrome, was susceptible to podocyte injury and proteinuria. Aldosterone excess caused by adipocyte-derived aldosterone-releasing factors was suggested to underlie the nephropathy. High salt intake augmented MR activation in the kidney and exacerbated the nephropathy. Furthermore, we identified an alternative pathway of MR activation by small GTPase Rac1. RhoGDI alpha knockout mice, a model with Rac1 activation in the kidney, showed albuminuria, podocyte injury, and glomerulosclerosis. Renal injury in the knockout mice was accompanied by enhanced MR signaling in the kidney despite normoaldosteronemia, and was ameliorated by an MR antagonist, eplerenone. Moreover, Rac-specific inhibitor significantly reduced the nephropathy, concomitantly with repression of MR activation. In vitro transfection studies provided direct evidence of Rac1-mediated MR activation. In conclusion, our findings suggest that MR activation plays a pivotal role in the pathogenesis of chronic kidney disease in metabolic syndrome, and that MR may be activated both aldosterone dependently (via aldosterone-releasing factors) and independently (via Rac1). MR antagonists are promising antiproteinuric drugs in metabolic syndrome, although long-term effects on renal outcomes, mortality, and safety need to be established.
C1 Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Div Chron Kidney Dis,Bunkyo Ku, Tokyo 1138655, Japan.
C3 University of Tokyo
RP Nagase, M (corresponding author), Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Div Chron Kidney Dis,Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM mnagase-tky@umin.ac.jp
CR ANDO K, 2010, HYPERTENS RES
   ARRIZA JL, 1987, SCIENCE, V237, P268, DOI 10.1126/science.3037703
   Artune F, 2006, J MOL MED, V84, P737, DOI 10.1007/s00109-006-0082-0
   Beygui F, 2006, CIRCULATION, V114, P2604, DOI 10.1161/CIRCULATIONAHA.106.634626
   Bianchi S, 2006, KIDNEY INT, V70, P2116, DOI 10.1038/sj.ki.5001854
   Bidani AK, 2004, HYPERTENSION, V44, P595, DOI 10.1161/01.HYP.0000145180.38707.84
   Blasi ER, 2003, KIDNEY INT, V63, P1791, DOI 10.1046/j.1523-1755.2003.00929.x
   Bochud M, 2006, HYPERTENSION, V48, P239, DOI 10.1161/01.HYP.0000231338.41548.fc
   Bomback AS, 2007, NAT CLIN PRACT NEPHR, V3, P486, DOI 10.1038/ncpneph0575
   Brenner BM, 2001, NEW ENGL J MED, V345, P861, DOI 10.1056/NEJMoa011161
   Bridgham JT, 2006, SCIENCE, V312, P97, DOI 10.1126/science.1123348
   BRILLA CG, 1990, CIRC RES, V67, P1355, DOI 10.1161/01.RES.67.6.1355
   Cancelas JA, 2005, NAT MED, V11, P886, DOI 10.1038/nm1274
   Chander PN, 2003, J AM SOC NEPHROL, V14, P1990, DOI 10.1097/01.ASN.0000078960.15147.05
   Chen HM, 2006, AM J KIDNEY DIS, V48, P772, DOI 10.1053/j.ajkd.2006.07.025
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   CONN JW, 1964, AM J SURG, V107, P159, DOI 10.1016/0002-9610(64)90252-1
   Durvasula RV, 2004, KIDNEY INT, V65, P30, DOI 10.1111/j.1523-1755.2004.00362.x
   DWORKIN LD, 1984, J CLIN INVEST, V73, P1448, DOI 10.1172/JCI111349
   Ehrhart-Bornstein M, 2003, P NATL ACAD SCI USA, V100, P14211, DOI 10.1073/pnas.2336140100
   Endlich N, 2002, FASEB J, V16, P1850, DOI 10.1096/fj.02-0125fje
   Epstein M, 2006, AM J MED, V119, P912, DOI 10.1016/j.amjmed.2006.03.038
   Fallo F, 2006, J CLIN ENDOCR METAB, V91, P454, DOI 10.1210/jc.2005-1733
   Fiebeler A, 2005, CIRCULATION, V111, P3087, DOI 10.1161/CIRCULATIONAHA.104.521625
   FUNDER JW, 1988, SCIENCE, V242, P583, DOI 10.1126/science.2845584
   Gao Y, 2004, P NATL ACAD SCI USA, V101, P7618, DOI 10.1073/pnas.0307512101
   Gomez-Sanchez EP, 2003, AM J PHYSIOL-ENDOC M, V285, pE272, DOI 10.1152/ajpendo.00409.2002
   Goodfriend TL, 2004, HYPERTENSION, V43, P518, DOI 10.1161/01.HYP.0000116223.97436.e5
   Goodfriend TL, 2004, HYPERTENSION, V43, P358, DOI 10.1161/01.HYP.0000113294.06704.64
   Greene EL, 1996, J CLIN INVEST, V98, P1063, DOI 10.1172/JCI118867
   Güder G, 2007, CIRCULATION, V115, P1754, DOI 10.1161/CIRCULATIONAHA.106.653964
   Guo C, 2006, ENDOCRINOLOGY, V147, P5363, DOI 10.1210/en.2006-0944
   HENE RJ, 1982, KIDNEY INT, V21, P98, DOI 10.1038/ki.1982.14
   HORIUCHI M, 1993, AM J PHYSIOL, V264, pF286, DOI 10.1152/ajprenal.1993.264.2.F286
   Hostetter TH, 2003, J AM SOC NEPHROL, V14, P2395, DOI 10.1097/01.ASN.0000086472.65806.73
   Ingelsson E, 2007, CIRCULATION, V116, P984, DOI 10.1161/CIRCULATIONAHA.107.708537
   Jafar TH, 2001, ANN INTERN MED, V135, P73, DOI 10.7326/0003-4819-135-2-200107170-00007
   Jeon JH, 2008, FASEB J, V22, P1502, DOI 10.1096/fj.07-9412com
   Kataoka S, 2002, J CLIN ENDOCR METAB, V87, P877, DOI 10.1210/jc.87.2.877
   KATO S, 1995, SCIENCE, V270, P1491, DOI 10.1126/science.270.5241.1491
   Kawashima T, 2006, J CELL BIOL, V175, P937, DOI 10.1083/jcb.200604073
   Kidambi S, 2007, HYPERTENSION, V49, P704, DOI 10.1161/01.HYP.0000253258.36141.c7
   Kim KY, 2006, FEBS LETT, V580, P3953, DOI 10.1016/j.febslet.2006.06.034
   Kino T, 2006, J BIOL CHEM, V281, P9118, DOI 10.1074/jbc.M509339200
   KRETZLER M, 1994, VIRCHOWS ARCH, V425, P181
   Kumar JM, 1999, J AM SOC NEPHROL, V10, P2488
   Kurella M, 2005, J AM SOC NEPHROL, V16, P2134, DOI 10.1681/ASN.2005010106
   Le Menuet D, 2001, J BIOL CHEM, V276, P38911, DOI 10.1074/jbc.M103984200
   Lea WB, 2009, KIDNEY INT, V75, P936, DOI 10.1038/ki.2009.9
   Lewis EJ, 2001, NEW ENGL J MED, V345, P851, DOI 10.1056/NEJMoa011303
   LEWIS EJ, 1993, NEW ENGL J MED, V329, P1456, DOI 10.1056/NEJM199311113292004
   Maschio G, 1996, NEW ENGL J MED, V334, P939, DOI 10.1056/NEJM199604113341502
   Matsui H, 2008, HYPERTENSION, V52, P287, DOI 10.1161/HYPERTENSIONAHA.108.111815
   Mehdi UF, 2009, J AM SOC NEPHROL, V20, P2641, DOI 10.1681/ASN.2009070737
   Nagase M, 2006, J AM SOC NEPHROL, V17, P3438, DOI 10.1681/ASN.2006080944
   Nagase M, 2006, HYPERTENSION, V47, P1084, DOI 10.1161/01.HYP.0000222003.28517.99
   Nagata K, 2006, HYPERTENSION, V47, P656, DOI 10.1161/01.HYP.0000203772.78696.67
   Navaneethan SD, 2009, CLIN J AM SOC NEPHRO, V4, P542, DOI 10.2215/CJN.04750908
   Ouvrard-Pascaud A, 2005, CIRCULATION, V111, P3025, DOI 10.1161/CIRCULATIONAHA.104.503706
   Pagtalunan ME, 1997, J CLIN INVEST, V99, P342, DOI 10.1172/JCI119163
   Parving HH, 2001, NEW ENGL J MED, V345, P870, DOI 10.1056/NEJMoa011489
   Pavenstädt H, 2003, PHYSIOL REV, V83, P253, DOI 10.1152/physrev.00020.2002
   Pitt B, 2003, NEW ENGL J MED, V348, P1309, DOI 10.1056/NEJMoa030207
   Pitt B, 2003, CIRCULATION, V108, P1831, DOI 10.1161/01.CIR.0000091405.00772.6E
   Pitt B, 1999, NEW ENGL J MED, V341, P709, DOI 10.1056/NEJM199909023411001
   QUAN ZY, 1992, KIDNEY INT, V41, P326, DOI 10.1038/ki.1992.45
   Quinkler M, 2005, CIRCULATION, V112, P1435, DOI 10.1161/CIRCULATIONAHA.105.539122
   Ribstein J, 2005, J AM SOC NEPHROL, V16, P1320, DOI 10.1681/ASN.2004100878
   Rocha R, 1999, HYPERTENSION, V33, P232, DOI 10.1161/01.HYP.33.1.232
   Rossi GP, 2006, HYPERTENSION, V48, P232, DOI 10.1161/01.HYP.0000230444.01215.6a
   Russo P, 2007, AM J HYPERTENS, V20, P218, DOI 10.1016/j.amjhyper.2006.07.012
   Sato A, 2003, HYPERTENSION, V41, P64, DOI 10.1161/01.HYP.0000044937.95080.E9
   Selye H, 1943, ARCH PATHOL, V36, P19
   Shibata S, 2007, HYPERTENSION, V49, P355, DOI 10.1161/01.HYP.0000255636.11931.a2
   Shibata S, 2008, NAT MED, V14, P1370, DOI 10.1038/nm.1879
   STAESSEN J, 1981, J ENDOCRINOL, V91, P457, DOI 10.1677/joe.0.0910457
   Su LF, 2001, J BIOL CHEM, V276, P3231, DOI 10.1074/jbc.M005547200
   Takai Y, 2001, PHYSIOL REV, V81, P153, DOI 10.1152/physrev.2001.81.1.153
   Terada Y, 2005, J AM SOC NEPHROL, V16, P2296, DOI 10.1681/ASN.2005020129
   Togawa A, 1999, ONCOGENE, V18, P5373, DOI 10.1038/sj.onc.1202921
   Tryggvason K, 2006, NEW ENGL J MED, V354, P1387, DOI 10.1056/NEJMra052131
   Vasan RS, 2004, NEW ENGL J MED, V351, P33, DOI 10.1056/NEJMoa033263
   Verhave JC, 2004, J INTERN MED, V256, P324, DOI 10.1111/j.1365-2796.2004.01390.x
   Weber KT, 2001, NEW ENGL J MED, V345, P1689, DOI 10.1056/NEJMra000050
   Williams GH, 2004, AM J CARDIOL, V93, P990, DOI 10.1016/j.amjcard.2004.01.007
   Wolf G, 2005, DIABETES, V54, P1626, DOI 10.2337/diabetes.54.6.1626
   Wu XM, 2008, CELL, V133, P340, DOI 10.1016/j.cell.2008.01.052
   Yanagisawa J, 1999, SCIENCE, V283, P1317, DOI 10.1126/science.283.5406.1317
   YOUNG M, 1994, J CLIN INVEST, V93, P2578, DOI 10.1172/JCI117269
NR 89
TC 30
Z9 33
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1342-1751
J9 CLIN EXP NEPHROL
JI Clin. Exp. Nephrol.
PD AUG
PY 2010
VL 14
IS 4
BP 303
EP 314
DI 10.1007/s10157-010-0298-8
PG 12
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Urology & Nephrology
GA 634OZ
UT WOS:000280594100001
PM 20533072
DA 2025-06-11
ER

PT J
AU Bouvet, C
   de Chantemèle, EB
   Guihot, AL
   Vessières, E
   Bocquet, A
   Dumont, O
   Jardel, A
   Loufrani, L
   Moreau, P
   Henrion, D
AF Bouvet, Celine
   de Chantemele, Eric Belin
   Guihot, Anne-Laure
   Vessieres, Emilie
   Bocquet, Arnaud
   Dumont, Odile
   Jardel, Alain
   Loufrani, Laurent
   Moreau, Pierre
   Henrion, Daniel
TI Flow-induced remodeling in resistance arteries from obese Zucker rats is
   associated with endothelial dysfunction
SO HYPERTENSION
LA English
DT Article; Proceedings Paper
CT 6th International Workshop on Structure and Function of the Vascular
   System
CY FEB 01-03, 2007
CL Paris, FRANCE
DE resistance arteries; shear stress; NO; reactive oxygen species;
   mechanotransduction; obesity; metabolic syndrome
ID NITRIC-OXIDE; BLOOD-FLOW; MECHANICAL-BEHAVIOR; DEPENDENT DILATION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; CAROTID-ARTERY; NO; ADAPTATION;
   PREVALENCE
AB Chronic increases in blood flow increase arterial diameter and NO-dependent dilation in resistance arteries. Because endothelial dysfunction accompanies metabolic syndrome, we hypothesized that flow- mediated remodeling might be impaired in obese rat resistance arteries. Obese and lean Zucker rat mesenteric resistance arteries were exposed to chronic flow increases through arterial ligation in vivo: arteries exposed to high flow were compared with normal flow arteries. Diameter was measured in vitro in cannulated arteries using pressure arteriography. After 7 days, outward remodeling ( diameter increased from 346 +/- 9 to 412 +/- 11 mu m at 100 mm Hg) occurred in lean high- flow arteries. Endothelium- dependent tone was reduced in high- flow arteries from obese rats by contrast with lean animals. On the other hand, diameter enlargement occurred similarly in the 2 strains. The involvement of NO in endothelium- dependent dilation ( evidenced by NO blockade) and endothelial NO synthase phosphorylation was smaller in obese than in lean rats. Superoxide anion and reduced nicotinamide- adenine dinucleotide phosphate oxidase subunit expression ( p67phox and gp91phox) increased in obese rats and were higher in high- flow than in control arteries. Acute Tempol ( a catalase mimetic), catalase plus superoxide dismutase, and L- arginine plus tetrahydrobiopterin restored endothelium- dependent dilation in obese rat normal and high- flow arteries to the level found in lean control arteries. Thus, flow- induced remodeling in obese resistance arteries was associated with a reduced endothelium- mediated dilation because of a decreased NO bioavailability and an excessive superoxide production. This dysfunction might have negative consequences in ischemic diseases in patients with obesity or metabolic syndrome.
C1 Univ Angers, UMR 6214, Dept Integrated Neurovasc Biol,CNRS, Inst Natl Sante & Rech 771,Fac Med, F-49045 Angers, France.
   Univ Montreal, Fac Pharm, Montreal, PQ H3C 3J7, Canada.
C3 Centre National de la Recherche Scientifique (CNRS); Universite
   d'Angers; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite de Montreal
RP Henrion, D (corresponding author), Univ Angers, UMR 6214, Dept Integrated Neurovasc Biol,CNRS, Inst Natl Sante & Rech 771,Fac Med, F-49045 Angers, France.
EM daniel.henrion@univ-angers.fr
RI de Chantemele, Eric/H-8923-2019; Moreau, Pierre/JHU-2540-2023; Henrion,
   Daniel/N-7023-2015; loufrani, laurent/K-1713-2015; vessieres,
   emilie/K-1894-2015; Henrion, Daniel/J-8141-2015
OI Belin de Chantemele, Eric J./0000-0002-0184-3830; Henrion,
   Daniel/0000-0003-1094-0285; Moreau, Pierre/0000-0002-3604-721X
CR Alp NJ, 2004, ARTERIOSCL THROM VAS, V24, P413, DOI 10.1161/01.ATV.0000110785.96039.f6
   Bagi Z, 2004, AM J PHYSIOL-HEART C, V287, pH626, DOI 10.1152/ajpheart.00074.2004
   Bagi Z, 2003, AM J PHYSIOL-HEART C, V285, pH1404, DOI 10.1152/ajpheart.00235.2003
   Bohlen HG, 2004, AM J PHYSIOL-HEART C, V286, pH492, DOI 10.1152/ajpheart.00818.2003
   Castier Y, 2005, CIRC RES, V97, P533, DOI 10.1161/01.RES.0000181759.63239.21
   Ceiler DL, 2000, ARTERIOSCL THROM VAS, V20, P2057, DOI 10.1161/01.ATV.20.9.2057
   Dumont O, 2007, ARTERIOSCL THROM VAS, V27, P317, DOI 10.1161/01.ATV.0000254684.80662.44
   Frisbee JC, 2001, AM J PHYSIOL-HEART C, V281, pH1304, DOI 10.1152/ajpheart.2001.281.3.H1304
   Frisbee JC, 2003, AM J PHYSIOL-HEART C, V285, pH104, DOI 10.1152/ajpheart.00118.2003
   Gorny D, 2002, MICROVASC RES, V64, P127, DOI 10.1006/mvre.2002.2417
   HALPERN W, 1984, ANN BIOMED ENG, V12, P463, DOI 10.1007/BF02363917
   Hu G, 2004, ARCH INTERN MED, V164, P1066, DOI 10.1001/archinte.164.10.1066
   Iannuzzi A, 2005, AM J CARDIOL, V96, P1164, DOI 10.1016/j.amjcard.2005.06.048
   Jin JS, 1997, AM J PHYSIOL-HEART C, V272, pH728, DOI 10.1152/ajpheart.1997.272.2.H728
   KURTZ TW, 1989, HYPERTENSION, V13, P896, DOI 10.1161/01.HYP.13.6.896
   Loufrani L, 2002, CIRC RES, V91, P1183, DOI 10.1161/01.RES.0000047505.11002.81
   Loufrani L, 2001, FASEB J, V15, P117, DOI 10.1096/fj.01-0505fje
   Mokdad AH, 2001, JAMA-J AM MED ASSOC, V286, P1195, DOI 10.1001/jama.286.10.1195
   Pourageaud F, 1997, AM J PHYSIOL-HEART C, V273, pH1699, DOI 10.1152/ajpheart.1997.273.4.H1699
   Steinberg HO, 1996, J CLIN INVEST, V97, P2601, DOI 10.1172/JCI118709
   Sun D, 1998, MICROVASC RES, V56, P54, DOI 10.1006/mvre.1998.2083
   Sun D, 2004, AM J PHYSIOL-HEART C, V286, pH2249, DOI 10.1152/ajpheart.00854.2003
   Thomas GN, 2004, ARTERIOSCL THROM VAS, V24, P739, DOI 10.1161/01.ATV.0000118015.26978.07
   Tronc F, 1996, ARTERIOSCL THROM VAS, V16, P1256, DOI 10.1161/01.ATV.16.10.1256
   Tulis DA, 1998, AM J PHYSIOL-HEART C, V274, pH874, DOI 10.1152/ajpheart.1998.274.3.H874
   Tuttle JL, 2001, AM J PHYSIOL-HEART C, V281, pH1380, DOI 10.1152/ajpheart.2001.281.3.H1380
   Unthank JL, 1996, CIRC RES, V79, P1015, DOI 10.1161/01.RES.79.5.1015
   Varin R, 2000, CIRCULATION, V102, P351
   Wild S, 2004, DIABETES CARE, V27, P1047, DOI 10.2337/diacare.27.5.1047
   Zanchi A, 1995, J HYPERTENS, V13, P1463
NR 30
TC 70
Z9 77
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD JUL
PY 2007
VL 50
IS 1
BP 248
EP 254
DI 10.1161/HYPERTENSIONAHA.107.088716
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology
GA 180XP
UT WOS:000247401600040
PM 17515452
DA 2025-06-11
ER

PT J
AU Bordoni, A
   Boesch, C
   Malpuech-Brugère, C
   Orfila, C
   Tomás-Cobos, L
AF Bordoni, A.
   Boesch, C.
   Malpuech-Brugere, C.
   Orfila, C.
   Tomas-Cobos, L.
TI The role of bioactives in energy metabolism and metabolic syndrome
SO PROCEEDINGS OF THE NUTRITION SOCIETY
LA English
DT Article; Proceedings Paper
CT Summer Meeting of the Nutrition-Society / Conference on Getting Energy
   Balance Right / Symposium 3 on Dietary Factors in Energy Metabolism
CY JUL 10-12, 2018
CL Univ Leeds, Leeds, ENGLAND
SP Nutr Soc
HO Univ Leeds
DE Anthocyanins; beta-glucan; Catechins; n-3 long chain PUFA; Metabolic
   syndrome
ID POLYUNSATURATED FATTY-ACIDS; OAT BETA-GLUCAN; RANDOMIZED
   CONTROLLED-TRIAL; POSTPRANDIAL BLOOD-GLUCOSE; SYNDROME RISK-FACTORS;
   WHOLE-GRAIN INTAKE; INSULIN-RESISTANCE; DIETARY SUPPLEMENTATION;
   OXIDATIVE STRESS; TEA CONSUMPTION
AB Some food bioactives potentially exert anti-obesity effects. Anthocyanins (ACN), catechins, beta-glucan (BG) and n-3 long chain PUFA (LCPUFA) are among the most promising candidates and have been considered as a strategy for the development of functional foods counteracting body weight gain. At present, clinical trials, reviews and meta-analyses addressing anti-obesity effects of various bioactives or bioactive-rich foods show contradictory results. Abdominal obesity is an important criterion for metabolic syndrome (MetS) diagnosis along with glucose intolerance, dyslipidaemia and hypertension. Food bioactives are supposed to exert beneficial effects on these parameters, therefore representing alternative therapy approaches for the treatment of MetS. This review summarises outcomes on MetS biomarkers in recent clinical trials supplementing ACN, catechins, BG and n-3 LCPUFA, focusing mainly on anti-obesity effects. Overall, it is clear that the level of evidence for the effectiveness varies not only among the different bioactives but also among the different putative health benefits suggested for the same bioactive. Limited evidence may be due to the low number of controlled intervention trials or to inconsistencies in trial design, i.e. duration, dose and/or the method of bioactive supplementation (extracts, supplements, rich or enriched food). At present, the question 'Are bioactives effective in weight management and prevention of metabolic syndrome?' remains inconclusive. Thus, a common effort to harmonise the study design of intervention trials focusing on the most promising bioactive molecules is urgently needed to strengthen the evidence of their potential in the treatment of obesity, MetS and related diseases.
C1 [Bordoni, A.] Univ Bologna, Dept Agrifood Sci & Technol, Cesena, FC, Italy.
   [Boesch, C.; Orfila, C.] Univ Leeds, Sch Food Sci & Nutr, Leeds, W Yorkshire, England.
   [Malpuech-Brugere, C.] Univ Clermont Auvergne, INRA, UNH, Unite Nutr Humaine,CRNH Auvergne, Clermont Ferrand, France.
   [Tomas-Cobos, L.] AINIA, Valencia, Spain.
C3 University of Bologna; University of Leeds; INRAE; Universite Clermont
   Auvergne (UCA)
RP Bordoni, A (corresponding author), Univ Bologna, Dept Agrifood Sci & Technol, Cesena, FC, Italy.
EM alessandra.bordoni@unibo.it
RI Bosch, Christine/AGL-4328-2022; Bordoni, Alessandra/J-3047-2012;
   Malpuech-Brugere, Corinne/D-6848-2017; Tomas-Cobos, Lidia/Q-2707-2018
OI Malpuech-Brugere, Corinne/0000-0001-9286-4647; Tomas-Cobos,
   Lidia/0000-0002-4996-6987; Bosch, Christine/0000-0001-6705-5709; Orfila,
   Caroline/0000-0003-2564-8068
CR Alvarado J, 2016, PANMINERVA MED, V58
   Amiot MJ, 2016, OBES REV, V17, P573, DOI 10.1111/obr.12409
   [Anonymous], NUTRIENTS
   [Anonymous], CLIN NUTR
   [Anonymous], 2017, NUTRIENTS
   [Anonymous], SCI GUID SUBST HLTH
   Beck EJ, 2010, BRIT J NUTR, V103, P1212, DOI 10.1017/S0007114509992856
   Behall KM, 2006, J AM DIET ASSOC, V106, P1445, DOI 10.1016/j.jada.2006.06.010
   Belwal T, 2017, NUTRIENTS, V9, DOI 10.3390/nu9101111
   Bernatoniene J, 2018, MOLECULES, V23, DOI 10.3390/molecules23040965
   Biörklund M, 2005, EUR J CLIN NUTR, V59, P1272, DOI 10.1038/sj.ejcn.1602240
   Bondia-Pons I, 2014, MOL NUTR FOOD RES, V58, P1873, DOI 10.1002/mnfr.201400155
   Bordoni A, 2006, GENES NUTR, V1, P95, DOI 10.1007/BF02829951
   Bosy-Westphal A, 2015, CURR OPIN CLIN NUTR, V18, P446, DOI 10.1097/MCO.0000000000000201
   Braicu C, 2013, FOOD CHEM, V141, P3282, DOI 10.1016/j.foodchem.2013.05.122
   Broncel M, 2010, MED SCI MONITOR, V16, pCR28
   Castro-Acosta ML, 2016, J NUTR BIOCHEM, V38, P154, DOI 10.1016/j.jnutbio.2016.09.002
   Castro-Acosta ML, 2016, P NUTR SOC, V75, P342, DOI 10.1017/S0029665116000240
   Charlton KE, 2012, BRIT J NUTR, V107, P1037, DOI 10.1017/S0007114511003850
   Barbosa MMDL, 2017, NUTRITION, V34, P7, DOI 10.1016/j.nut.2016.08.010
   Desch S, 2010, AM J HYPERTENS, V23, P97, DOI 10.1038/ajh.2009.213
   Eckel RH, 2010, LANCET, V375, P181, DOI 10.1016/S0140-6736(09)61794-3
   Eisenstein J, 2002, NUTR REV, V60, P189, DOI 10.1301/00296640260184264
   Evans CEL, 2015, J HYPERTENS, V33, P897, DOI 10.1097/HJH.0000000000000515
   Fukino Y, 2005, J NUTR SCI VITAMINOL, V51, P335, DOI 10.3177/jnsv.51.335
   Grundy MML, 2018, FOOD FUNCT, V9, P1328, DOI 10.1039/c7fo02006f
   Gunness P, 2016, FASEB J, V30, P4227, DOI 10.1096/fj.201600465R
   Hames KC, 2017, AM J CLIN NUTR, V105, P1552, DOI 10.3945/ajcn.116.148114
   Hartley L, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009934.pub2
   Hassellund SS, 2013, J HUM HYPERTENS, V27, P100, DOI 10.1038/jhh.2012.4
   He LX, 2016, FOOD FUNCT, V7, P1413, DOI 10.1039/c5fo01364j
   Hibi M, 2018, NUTR RES, V55, P1, DOI 10.1016/j.nutres.2018.03.012
   Hooper L, 2012, AM J CLIN NUTR, V95, P740, DOI 10.3945/ajcn.111.023457
   Hosoda K, 2003, DIABETES CARE, V26, P1714, DOI 10.2337/diacare.26.6.1714
   Hsu Chung-Hua, 2011, Altern Med Rev, V16, P157
   Ibrügger S, 2013, J NUTR, V143, P1579, DOI [10.3945/jn.112.173064, 10.3945/jn.112.173054]
   Jennings A, 2014, J NUTR, V144, P202, DOI 10.3945/jn.113.184358
   Jing YL, 2009, J GEN INTERN MED, V24, P557, DOI 10.1007/s11606-009-0929-5
   Johnson MH, 2016, J AGR FOOD CHEM, V64, P2569, DOI 10.1021/acs.jafc.6b00239
   Kalupahana NS, 2011, ADV NUTR, V2, P304, DOI 10.3945/an.111.000505
   Kerckhoffs DAJM, 2003, AM J CLIN NUTR, V78, P221, DOI 10.1093/ajcn/78.2.221
   Keske MA, 2015, CURR MED CHEM, V22, P59
   Khoo HE, 2017, FOOD NUTR RES, V61, P1, DOI 10.1080/16546628.2017.1361779
   Lavie CJ, 2009, J AM COLL CARDIOL, V54, P585, DOI 10.1016/j.jacc.2009.02.084
   Lee TC, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-196
   Legeay S, 2015, NUTRIENTS, V7, P5443, DOI 10.3390/nu7075230
   Lehtonen HM, 2011, EUR J CLIN NUTR, V65, P394, DOI 10.1038/ejcn.2010.268
   Liu X, 2016, OBESITY, V24, P2261, DOI 10.1002/oby.21584
   Lopez-Huertas E, 2012, BRIT J NUTR, V107, pS185, DOI 10.1017/S0007114512001572
   Lorente-Cebrián S, 2013, J PHYSIOL BIOCHEM, V69, P633, DOI 10.1007/s13105-013-0265-4
   Lovegrove JA, 2000, AM J CLIN NUTR, V72, P49
   Luna-Vital DA, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0200449
   Mackie A, 2016, J FUNCT FOODS, V26, P418, DOI 10.1016/j.jff.2016.08.018
   MARGETTS BM, 1987, CLIN SCI, V72, P343, DOI 10.1042/cs0720343
   Martínez-Victoria E, 2012, BRIT J NUTR, V107, pS107, DOI 10.1017/S000711451200150X
   Matsukawa T, 2015, J NUTR BIOCHEM, V26, P860, DOI 10.1016/j.jnutbio.2015.03.006
   McKeown NM, 2002, AM J CLIN NUTR, V76, P390, DOI 10.1093/ajcn/76.2.390
   Mielgo-Ayuso J, 2014, BRIT J NUTR, V111, P1263, DOI 10.1017/S0007114513003784
   Moazen S, 2013, ANN NUTR METAB, V63, P256, DOI 10.1159/000356053
   Nieto JA, 2017, FOOD AGR IMMUNOL, V28, P1507, DOI 10.1080/09540105.2017.1350832
   Oh PC, 2014, INT J CARDIOL, V176, P696, DOI 10.1016/j.ijcard.2014.07.075
   Ortega JF, 2016, OBESITY, V24, P1704, DOI 10.1002/oby.21552
   Osakabe N, 2013, J CLIN BIOCHEM NUTR, V52, P186, DOI 10.3164/jcbn.12-130
   Parra D, 2008, APPETITE, V51, P676, DOI 10.1016/j.appet.2008.06.003
   Ramprasath VR, 2015, TRIALS, V16, DOI 10.1186/s13063-015-1014-5
   Roubroeks JP, 2000, BIOMACROMOLECULES, V1, P584, DOI 10.1021/bm000017+
   Rózanska D, 2018, ADV CLIN EXP MED, V27, P135, DOI 10.17219/acem/64983
   Sacks FM, 2009, NEW ENGL J MED, V360, P859, DOI 10.1056/NEJMoa0804748
   Sahyoun NR, 2006, AM J CLIN NUTR, V83, P124
   Sakulnarmrat K, 2014, LWT-FOOD SCI TECHNOL, V57, P366, DOI 10.1016/j.lwt.2014.01.002
   Scazzocchio B, 2011, DIABETES, V60, P2234, DOI 10.2337/db10-1461
   Shimada K, 2004, DIABETES RES CLIN PR, V65, P227, DOI 10.1016/j.diabres.2004.01.003
   Skates E, 2018, FOOD CHEM TOXICOL, V111, P445, DOI 10.1016/j.fct.2017.11.032
   Soltani R, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/740954
   Solverson PM, 2018, NUTRIENTS, V10, DOI 10.3390/nu10081048
   Steck TR, 2012, J MICROBIOL BIOL EDU, V13, P2, DOI 10.1128/jmbe.v13i1.389
   Suzuki T, 2016, MOLECULES, V21, DOI 10.3390/molecules21101305
   Tardivo AP, 2015, CLIMACTERIC, V18, P290, DOI 10.3109/13697137.2014.981521
   Tessari P, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030297
   Thandapilly SJ, 2018, FOOD FUNCT, V9, P3092, DOI [10.1039/c8fo00157j, 10.1039/C8FO00157J]
   Tiwari U, 2011, NUTRITION, V27, P1008, DOI 10.1016/j.nut.2010.11.006
   Tokede OA, 2011, EUR J CLIN NUTR, V65, P879, DOI 10.1038/ejcn.2011.64
   Torres-Fuentes C, 2015, NUTR NEUROSCI, V18, P49, DOI 10.1179/1476830513Y.0000000099
   Tosh SM, 2013, EUR J CLIN NUTR, V67, P310, DOI 10.1038/ejcn.2013.25
   Tovar J, 2016, EUR J NUTR, V55, P2295, DOI 10.1007/s00394-015-1039-2
   Tovar J, 2014, BRIT J NUTR, V111, P706, DOI 10.1017/S000711451300305X
   Vendrame S, 2016, ANTIOXIDANTS-BASEL, V5, DOI 10.3390/antiox5040034
   Venturini D, 2015, NUTRITION, V31, P834, DOI 10.1016/j.nut.2014.12.016
   Whitehead A, 2014, AM J CLIN NUTR, V100, P1413, DOI 10.3945/ajcn.114.086108
   Wolever TMS, 2010, AM J CLIN NUTR, V92, P723, DOI 10.3945/ajcn.2010.29174
   Wu T, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/4051232
   Yang LP, 2017, ADV NUTR, V8, P684, DOI 10.3945/an.116.014852
   Yubero-Serrano EM, 2015, AM J CLIN NUTR, V102, P1509, DOI 10.3945/ajcn.115.111286
   Zhu YN, 2014, J CLIN ENDOCR METAB, V99, P561, DOI 10.1210/jc.2013-2845
NR 94
TC 15
Z9 15
U1 2
U2 37
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0029-6651
EI 1475-2719
J9 P NUTR SOC
JI Proc. Nutr. Soc.
PD AUG
PY 2019
VL 78
IS 3
BP 340
EP 350
AR PII S0029665119000545
DI 10.1017/S0029665119000545
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics
GA IO0OP
UT WOS:000479078500010
PM 30967168
OA Green Submitted, Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Iorio, A
   Ylli, D
   Polimanti, R
   Picconi, F
   Maggio, P
   Francomano, D
   Aversa, A
   Manfellotto, D
   Fuciarelli, M
   Frontoni, S
AF Iorio, Andrea
   Ylli, Dorina
   Polimanti, Renato
   Picconi, Fabiana
   Maggio, Paola
   Francomano, Davide
   Aversa, Antonio
   Manfellotto, Dario
   Fuciarelli, Maria
   Frontoni, Simona
TI Effect of the GSTM1 gene deletion on glycemic variability,
   sympatho-vagal balance and arterial stiffness in patients with metabolic
   syndrome, but without diabetes
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE Genetic polymorphisms; Glucose excursions; AMP-activated protein kinase;
   Autonomic function; Metabolic syndrome
ID CARDIOVASCULAR OUTCOMES; INSULIN RESISTANCE; PULSE PRESSURE; INCREASED
   RISK; GLUCOSE; ACTIVATION; DISEASE; GSTO2-ASTERISK-N142D; POLYMORPHISMS;
   HYPERGLYCEMIA
AB Aims: An increased rate of cerebrovascular complications in patients with metabolic syndrome (MetS) has been reported. Previous studies demonstrated an association between glycemic variability (GV) and cerebrovascular reactivity (CRV) in MetS, thus suggesting a putative role of GVon cerebrovascular events. Although the pathophysiological mechanism linking GV to damage is still to be elucidated, evidence suggests oxidative stress plays a crucial role. Since functional variants in glutathione S-transferases (GST) genes modulate the cellular detoxification processes, the aim of this study was to elucidate the involvement of GSTs in MetS and investigating the correlation with GV, arterial stiffness, and sympathovagal (SV) balance.
   Methods: A hundred metabolic syndrome patients without diabetes underwent GST gene polymorphism analysis and a sub-sample 36 patients were randomly selected to investigate the correlation between GST gene polymorphisms and GV, and sympatho-vagal (SV) balance and arterial stiffness.
   Results: GSTM1 showed a significant association with several GV, arterial stiffness, and SV balance indexes. In particular, the GSTM1 deletion positively correlates with lower values of these indexes when compared to the presence of the gene.
   Conclusions: Therefore, we suggested a global influence of GSTM1 deletion on the GV, arterial stiffness, and SV balance pathways in MetS patients, probably also interacting with AMP-activated protein kinase (AMPK) regulation.
   Conclusions: Our novel findings indicate GSTM1 could be a risk locus in MetS development and shed light novel scenarios on the role of glucose fluctuations in neurological impairments. (C) 2018 Elsevier B.V. All rights reserved.
C1 [Iorio, Andrea; Fuciarelli, Maria] Univ Roma Tor Vergata, Dept Biol, Rome, Italy.
   [Iorio, Andrea] Univ Roma Tor Vergata, Salugene Srls, Rome, Italy.
   [Ylli, Dorina; Picconi, Fabiana; Frontoni, Simona] Univ Roma Tor Vergata, S Giovanni Calibita Fatebenefratelli Hosp, Dept Syst Med, Endocrinol Diabet & Metab, Rome, Italy.
   [Polimanti, Renato] Yale Univ, Sch Med, Dept Psychiat, West Haven, CT USA.
   [Polimanti, Renato] VA CT Healthcare Ctr, West Haven, CT USA.
   [Maggio, Paola] Bolognini Hosp, ASST Bergamo Est, Dept Neurol, Seriate, BG, Italy.
   [Francomano, Davide] Madonna delle Grazie Hosp, Div Internal Med & Endocrinol, Rome, Italy.
   [Aversa, Antonio] Sapienza Univ Rome, Dept Expt Med, Sect Med Pathophysiol Endocrinol & Nutr, Rome, Italy.
   [Manfellotto, Dario] San Giovanni Calibita Fatebenefratelli Hosp, AFaR Fdn, Clin Pathophysiol Ctr, Rome, Italy.
C3 University of Rome Tor Vergata; University of Rome Tor Vergata;
   University of Rome Tor Vergata; Yale University; Sapienza University
   Rome
RP Frontoni, S (corresponding author), S Giovanni Calibita Fatebenefratelli Hosp, Endocrinol Diabet & Metab, Via Ponte Quattro Capi 39, I-00186 Rome, Italy.
EM frontoni@uniroma2.it
RI Picconi, Fabiana/AAB-9012-2019; Maggio, Paola/ABC-7526-2021; Polimanti,
   Renato/B-7577-2013; Aversa, Antonio/O-3151-2019; FRONTONI,
   SIMONA/J-4893-2012; Ylli, Dorina/IYJ-5338-2023
OI Maggio, Paola/0000-0001-8393-7699; Polimanti,
   Renato/0000-0003-0745-6046; Aversa, Antonio/0000-0002-2989-2618; Ylli,
   Dorina/0000-0002-0269-2587; FRONTONI, SIMONA/0000-0001-8241-7552
FU RSA Grant from University of Rome "Tor Vergata"; PRIN from the Italian
   Ministry of Instruction, University and Research (MIUR) [200975T9EW];
   Fatebenefratelli Foundation for Biomedical Research (AFaR division)
FX This study was supported by RSA Grant 2009 from University of Rome "Tor
   Vergata", by PRIN 2009-11 (Project No. 200975T9EW) from the Italian
   Ministry of Instruction, University and Research (MIUR) (M.F.) and by a
   grant from the Fatebenefratelli Foundation for Biomedical Research (AFaR
   division) (D.Y., F.P., D.M., S.F.). The authors declare no conflicts of
   interest.
CR Afrand M, 2015, IRAN J PUBLIC HEALTH, V44, P673
   Air EL, 2007, DIABETES CARE, V30, P3131, DOI 10.2337/dc06-1537
   Amer MA, 2011, GENET MOL RES, V10, P3722, DOI 10.4238/2011.October.31.14
   [Anonymous], 2015, DIABETES CARE, V38, pS8, DOI 10.2337/dc15-S005
   [Anonymous], CYTOKINE
   [Anonymous], J STAT SOFTW
   Aversa A, 2011, ANDROLOGIA, V43, P9, DOI 10.1111/j.1439-0272.2009.00998.x
   Baez-Duarte BG, 2016, METAB SYNDR RELAT D, V14, P154, DOI 10.1089/met.2015.0088
   Buscemi S, 2010, DIABETIC MED, V27, P872, DOI 10.1111/j.1464-5491.2010.03059.x
   Coughlan KA, 2014, DIABET METAB SYND OB, V7, P241, DOI 10.2147/DMSO.S43731
   Dekker JM, 2000, CIRCULATION, V102, P1239, DOI 10.1161/01.CIR.102.11.1239
   Di Flaviani A, 2011, DIABETES CARE, V34, P1605, DOI 10.2337/dc11-0034
   Domanski M, 2002, JAMA-J AM MED ASSOC, V287, P2677, DOI 10.1001/jama.287.20.2677
   Fleischer J, 2015, DIABETES CARE, V38, P682, DOI 10.2337/dc14-0654
   Frontoni S, 2013, DIABETES RES CLIN PR, V102, P86, DOI 10.1016/j.diabres.2013.09.007
   Giordani I, 2014, J CLIN ENDOCR METAB, V99, P2854, DOI 10.1210/jc.2014-1087
   Hirsch IB, 2015, DIABETES CARE, V38, P1610, DOI 10.2337/dc14-2898
   Iorio A, 2015, EUR J OBSTET GYN R B, V194, P34, DOI 10.1016/j.ejogrb.2015.08.006
   Iorio A, 2015, CLIN RESPIR J, V9, P481, DOI 10.1111/crj.12170
   Iorio A, 2014, AM J HUM BIOL, V26, P361, DOI 10.1002/ajhb.22520
   JAMERSON KA, 1993, HYPERTENSION, V21, P618, DOI 10.1161/01.HYP.21.5.618
   Karaca S, 2016, NUTRITION, V32, P693, DOI 10.1016/j.nut.2015.12.027
   Khodaeian M, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/585917
   Klaus A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0062497
   Licht CMM, 2013, J CLIN ENDOCR METAB, V98, P2484, DOI 10.1210/jc.2012-3104
   Luque-Contreras D, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/497802
   Masuo K, 1997, AM J HYPERTENS, V10, P77, DOI 10.1016/S0895-7061(96)00303-2
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McIlwain CC, 2006, ONCOGENE, V25, P1639, DOI 10.1038/sj.onc.1209373
   Miyatake S, 2014, BIOCHEM BIOPH RES CO, V444, P496, DOI 10.1016/j.bbrc.2014.01.089
   Monnier L, 2006, JAMA-J AM MED ASSOC, V295, P1681, DOI 10.1001/jama.295.14.1681
   Nakano S, 2005, DIABETES CARE, V28, P95, DOI 10.2337/diacare.28.1.95
   Nebert Daniel W., 2004, Human Genomics, V1, P460
   Piacentini S, 2014, CLIN EXP PHARMACOL P, V41, P180, DOI 10.1111/1440-1681.12201
   Piacentini S, 2013, MOL BIOL REP, V40, P1967, DOI 10.1007/s11033-012-2253-0
   Piacentini S, 2012, NEUROSCI LETT, V506, P203, DOI 10.1016/j.neulet.2011.11.005
   Picconi F, 2012, NUTR METAB CARDIOVAS, V22, P691, DOI 10.1016/j.numecd.2012.03.006
   Pinheiro DS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076262
   Polimanti R, 2011, MOL CELL BIOCHEM, V357, P227, DOI 10.1007/s11010-011-0893-3
   Pugazhenthi S, 2017, PROG MOL BIOL TRANSL, V146, P243, DOI 10.1016/bs.pmbts.2016.12.016
   Rafiee Laleh, 2016, Adv Biomed Res, V5, P63, DOI 10.4103/2277-9175.179185
   Rao DK, 2014, MOL BIOL REP, V41, P841, DOI 10.1007/s11033-013-2924-5
   Rojas-Gutierrez E, 2017, SYNAPSE, V71, DOI 10.1002/syn.21990
   Safar ME, 2003, CIRCULATION, V107, P2864, DOI 10.1161/01.CIR.0000069826.36125.B4
   Tune JD, 2017, TRANSL RES, V183, P57, DOI 10.1016/j.trsl.2017.01.001
   Vávrová L, 2013, OBESITY FACTS, V6, P39, DOI 10.1159/000348569
   Vinik AI, 2013, J DIABETES INVEST, V4, P4, DOI 10.1111/jdi.12042
   Yaffe K, 2004, JAMA-J AM MED ASSOC, V292, P2237, DOI 10.1001/jama.292.18.2237
   Zhang JW, 2013, GENE, V518, P405, DOI 10.1016/j.gene.2012.12.086
NR 49
TC 2
Z9 2
U1 0
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD APR
PY 2018
VL 138
BP 158
EP 168
DI 10.1016/j.diabres.2018.02.006
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GD4AS
UT WOS:000430445500020
PM 29452132
DA 2025-06-11
ER

PT J
AU Ferrara, LA
   Guida, L
   Ferrara, F
   De Luca, G
   Castaldo, R
   Viola, S
   Russo, R
AF Ferrara, L. Aldo
   Guida, Lucio
   Ferrara, Fabio
   De Luca, Giuliano
   Castaldo, Rosaria
   Viola, Stefania
   Russo, Raffaele
TI Blood pressure at rest, during 24 h monitoring and in response to
   sympathetic stimulation in hypertensive patients with metabolic syndrome
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE metabolic syndrome; sympathetic activity; ABPM; isometric exercise; cold
   pressure test
ID INSULIN; DIFFERENCE
AB Objective: As subjects with metabolic syndrome have an increased sympathetic activity regardless of the presence of arterial hypertension, this study aimed at evaluating in hypertensives whether this condition has repercussions on differences in resting, ambulatory and under sympathetic stimulation blood pressure levels.
   Methods: Blood pressure (BP) was measured at rest and in response to isometric exercise and cold pressure test by zero-random sphygmomanometer. Moreover 24 h BP monitoring was performed by using Spacelabs 90207.
   Results: Of the 340 hypertensive patients entering the study, 110 (32%) had metabolic syndrome. They were older (47 vs. 42 years, p < 0.01) than those without MS and, by definition, had increased body mass index, fasting blood glucose and triglycerides and lower HDL-cholesterol. Also BP at rest (148/95 vs. 140/90 mm Hg, p < 0.01), during 24 h (138/89 vs. 129/84 mm Hg, p < 0.001) as well as during daytime and nighttime were significantly increased in this group. No difference, on the other hand, was detected in the response to tests stimulating sympathetic nervous system and in the clinic-daytime BP difference.
   Conclusions: In the present study hypertensive patients with MS have higher BP, both at rest and during ambulatory monitoring in comparison to hypertensives without MS. The BP response to the stimulation of the sympathetic system seems, on the other hand, similar probably because the presence of hypertension in both groups masks during maximal stress the differences evident in less stressing conditions. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
C1 Univ Naples Federico II, Dipartimento Med Clin, I-80131 Naples, Italy.
C3 University of Naples Federico II
RP Ferrara, LA (corresponding author), Univ Naples Federico II, Dipartimento Med Clin, Via Sergio Pansini 5, I-80131 Naples, Italy.
EM Ferrara@Unina.It
CR ANDERSON EA, 1992, HYPERTENSION, V19, P621, DOI 10.1161/01.HYP.19.6.621
   Chinali M, 2004, AM J CARDIOL, V93, P40, DOI 10.1016/j.amjcard.2003.09.009
   Cuspidi C, 2004, J HYPERTENS, V22, P1991, DOI 10.1097/00004872-200410000-00023
   Ferrara LA, 2005, J HYPERTENS, V23, pS133
   Ferrara LA, 1997, J HYPERTENS, V15, P979, DOI 10.1097/00004872-199715090-00008
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Grassi G, 2005, DIABETOLOGIA, V48, P1359, DOI 10.1007/s00125-005-1798-z
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Guida L, 1999, J HYPERTENS, V17, P331, DOI 10.1097/00004872-199917030-00005
   Heine RJ, 2002, DIABETOLOGIA, V45, P461, DOI 10.1007/s00125-001-0726-0
   Huggett RJ, 2004, HYPERTENSION, V44, P847, DOI 10.1161/01.HYP.0000147893.08533.d8
   Landsberg L, 2001, J HYPERTENS, V19, P523, DOI 10.1097/00004872-200103001-00001
   Lopes HF, 2001, HYPERTENSION, V38, P616, DOI 10.1161/hy09t1.094504
   MANCIA G, 1987, HYPERTENSION, V9, P209, DOI 10.1161/01.HYP.9.2.209
   Orio F, 2004, J CLIN ENDOCR METAB, V89, P4588, DOI 10.1210/jc.2003-031867
   Parati G, 1998, HYPERTENSION, V31, P1185, DOI 10.1161/01.HYP.31.5.1185
   PICKERING TG, 1994, LANCET, V344, P31
   Reaven GM, 1996, NEW ENGL J MED, V334, P374, DOI 10.1056/NEJM199602083340607
   ROWE JW, 1981, DIABETES, V30, P219, DOI 10.2337/diab.30.3.219
   Stratton JR, 2003, J AM COLL CARDIOL, V41, P2077, DOI 10.1016/S0735-1097(03)00418-2
   WOOD DL, 1984, HYPERTENSION, V6, P301, DOI 10.1161/01.HYP.6.3.301
NR 21
TC 11
Z9 11
U1 0
U2 1
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD MAY 2
PY 2007
VL 117
IS 3
BP 312
EP 316
DI 10.1016/j.ijcard.2006.04.085
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 165PQ
UT WOS:000246318100004
PM 16863667
DA 2025-06-11
ER

PT J
AU Saunders, TJ
   McIsaac, T
   Douillette, K
   Gaulton, N
   Hunter, S
   Rhodes, RE
   Prince, SA
   Carson, V
   Chaput, JP
   Chastin, S
   Giangregorio, L
   Janssen, I
   Katzmarzyk, PT
   Kho, ME
   Poitras, VJ
   Powell, KE
   Ross, R
   Ross-White, A
   Tremblay, MS
   Healy, GN
AF Saunders, Travis J.
   McIsaac, Travis
   Douillette, Kevin
   Gaulton, Nick
   Hunter, Stephen
   Rhodes, Ryan E.
   Prince, Stephanie A.
   Carson, Valerie
   Chaput, Jean-Philippe
   Chastin, Sebastien
   Giangregorio, Lora
   Janssen, Ian
   Katzmarzyk, Peter T.
   Kho, Michelle E.
   Poitras, Veronica J.
   Powell, Kenneth E.
   Ross, Robert
   Ross-White, Amanda
   Tremblay, Mark S.
   Healy, Genevieve N.
TI Sedentary behaviour and health in adults: an overview of systematic
   reviews
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Review
DE sedentary behaviour; guidelines; public health; adults; sitting; screen
   time
ID ALL-CAUSE MORTALITY; PHYSICAL-ACTIVITY; SLEEP DURATION; OLDER-ADULTS;
   TIME; RISK; WORKSTATIONS; METAANALYSIS; PERFORMANCE; GUIDELINES
AB The purpose of this overview of systematic reviews was to determine the relationship between different types and patterns of sedentary behaviour and selected health outcomes in adults and older adults. Five electronic databases were last searched in May, 2019, with a 10-year search limit. Included reviews met the a priori population (community-dwelling adults aged 18 years and older), intervention/exposure/comparator (various types and/or patterns of sedentary behaviour), and outcomes criteria. Eighteen systematic reviews were included in the evidence synthesis. High levels of sedentary behaviour are unfavourably associated with cognitive function, depression, function and disability, physical activity levels, and physical health-related quality of life in adults. Reducing or breaking up sedentary behaviour may benefit body composition and markers of cardiometabolic risk. Total sedentary behaviour and TV viewing were most consistently associated with unfavourable health outcomes, while computer and Internet use may be favourably associated with cognitive function for older adults. The quality of evidence within individual reviews (as assessed by review authors) varied from low to high, while the certainty of evidence was low to very low. These findings have important public health implications, suggesting that adults should avoid high levels of sedentary behaviour and break-up periods of prolonged sitting. (PROSPERO registration nos.: CRD42019123121 and CRD42019127157.)
   Novelty
   High levels of sedentary behaviour are unfavourably associated with important health outcomes in adults.
   Reducing or breaking up sedentary behaviour may benefit body composition and markers of cardiometabolic risk.
   Computer and Internet use may be favourably associated with cognitive function in older adults.
C1 [Saunders, Travis J.; McIsaac, Travis; Douillette, Kevin; Gaulton, Nick] Univ Prince Edward Isl, Dept Appl Human Sci, Charlottetown, PE C1A 4P3, Canada.
   [Hunter, Stephen; Carson, Valerie] Univ Alberta, Fac Kinesiol Sport & Recreat, Edmonton, AB T6G 2H9, Canada.
   [Rhodes, Ryan E.] Univ Victoria, Sch Exercise Sci Phys & Hlth Educ, Victoria, BC V8P 5C2, Canada.
   [Prince, Stephanie A.] Univ Ottawa, Div Cardiac Prevent & Rehabil, Heart Inst, Ottawa, ON K1Y 4W7, Canada.
   [Chaput, Jean-Philippe; Tremblay, Mark S.] Childrens Hosp, Hlth Act Living & Obes Res Grp, Eastern Ontario Res Inst, Ottawa, ON K1H 8L1, Canada.
   [Chastin, Sebastien] Glasgow Caledonian Univ, Sch Hlth & Life Sci, Inst Appl Hlth Res, Glasgow G4 0BA, Lanark, Scotland.
   [Chastin, Sebastien] Univ Ghent, Dept Movement & Sport Sci, Ghent, Belgium.
   [Giangregorio, Lora] Univ Waterloo, Dept Kinesiol, Waterloo, ON N2L 3G1, Canada.
   [Giangregorio, Lora] Univ Waterloo, Schlegel UW Res Inst Aging, Waterloo, ON N2L 3G1, Canada.
   [Janssen, Ian; Ross, Robert] Queens Univ, Sch Kinesiol & Hlth Studies, Kingston, ON K7L 3N6, Canada.
   [Katzmarzyk, Peter T.] Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
   [Kho, Michelle E.] McMaster Univ, Sch Rehabil Sci, Hamilton, ON L8S 1C7, Canada.
   [Ross-White, Amanda] Queens Univ, Queens Univ Lib, Kingston, ON K7L 3N6, Canada.
   [Healy, Genevieve N.] Univ Queensland, Sch Publ Hlth, Herson, Qld 4006, Australia.
C3 University of Prince Edward Island; University of Alberta; University of
   Victoria; University of Ottawa; University of Ottawa Heart Institute;
   University of Ottawa; Children's Hospital of Eastern Ontario; Glasgow
   Caledonian University; Ghent University; University of Waterloo;
   University of Waterloo; Queens University - Canada; Louisiana State
   University System; Louisiana State University; Pennington Biomedical
   Research Center; McMaster University; Queens University - Canada;
   University of Queensland
RP Saunders, TJ (corresponding author), Univ Prince Edward Isl, Dept Appl Human Sci, Charlottetown, PE C1A 4P3, Canada.
EM trsaunders@upei.ca
RI Ross-White, Amanda/N-2408-2019; Tremblay, Mark/ABI-5477-2020; Chaput,
   Jean-Philippe/ABE-6307-2020; Katzmarzyk, Peter/N-1974-2017; Chastin,
   Sebastien/ABF-1455-2020; Prince, Stephanie/J-9361-2019; ,
   Michelle/W-7414-2019; Carson, Valerie/ABG-2853-2021; Janssen,
   Ian/B-7700-2009; Rhodes, Ryan/ABB-4896-2020; Healy,
   Genevieve/A-7408-2008
OI Kho, Michelle/0000-0003-3170-031X; Prince,
   Stephanie/0000-0001-6729-5649; Ross-White, Amanda/0000-0003-4737-0968;
   Rhodes, Ryan/0000-0003-0940-9040; Chastin,
   Sebastien/0000-0003-1421-9348; Healy, Genevieve/0000-0001-7093-7892
FU PHAC; Canadian Society for Exercise Physiology; Queen's University;
   National Health and Medical Research Council of Australia Career
   Development Fellowship; Canadian Institutes of Health Research - PHAC
   Health System Impact Fellowship
FX This study has been made possible through funding from the PHAC, the
   Canadian Society for Exercise Physiology, and Queen's University. I.J.
   and M.E.K. each hold a Canada Research Chair. G.N.H. was supported by a
   National Health and Medical Research Council of Australia Career
   Development Fellowship. S.A.P. was funded by a Canadian Institutes of
   Health Research -PHAC Health System Impact Fellowship. The funder had no
   role in the design, interpretation, and publication of this manuscript.
CR 2018 Physical Activity Guidelines Advisory Committee, 2018, PHYS ACT GUID ADV CO
   [Anonymous], 2004, STANDARD QUALITY ASS
   Balshem H, 2011, J CLIN EPIDEMIOL, V64, P401, DOI 10.1016/j.jclinepi.2010.07.015
   Becker LA, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001726.pub4
   Boberska M, 2018, HEALTH PSYCHOL REV, V12, P195, DOI 10.1080/17437199.2017.1396191
   Carson V, 2014, PREV MED, V65, P23, DOI 10.1016/j.ypmed.2014.04.005
   Castro O, 2018, PREV MED, V116, P194, DOI 10.1016/j.ypmed.2018.09.016
   Chaput JP, 2020, APPL PHYSIOL NUTR ME, V45, pS232, DOI 10.1139/apnm-2020-0032
   Chaput JP, 2020, APPL PHYSIOL NUTR ME, V45, pS218, DOI 10.1139/apnm-2020-0034
   Chastin SFM, 2019, BRIT J SPORT MED, V53, P370, DOI 10.1136/bjsports-2017-097563
   Chastin SFM, 2015, INT J BEHAV NUTR PHY, V12, DOI 10.1186/s12966-015-0292-3
   Chastin SFM, 2015, OBESITY, V23, P1800, DOI 10.1002/oby.21180
   Church TS, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019657
   Craggs C, 2011, AM J PREV MED, V40, P645, DOI 10.1016/j.amepre.2011.02.025
   Downs SH, 1998, J EPIDEMIOL COMMUN H, V52, P377, DOI 10.1136/jech.52.6.377
   El-Kotob R, 2020, APPL PHYSIOL NUTR ME, V45, pS165, DOI 10.1139/apnm-2020-0245
   Falck RS, 2017, BRIT J SPORT MED, V51, P800, DOI 10.1136/bjsports-2015-095551
   Fried LP, 2001, J GERONTOL A-BIOL, V56, pM146, DOI 10.1093/gerona/56.3.M146
   Grontved A, 2011, JAMA-J AM MED ASSOC, V305, P2448, DOI 10.1001/jama.2011.812
   Hallgren M, 2020, EXERC SPORT SCI REV, V48, P20, DOI 10.1249/JES.0000000000000211
   Higgins JP, 2011, BMJ, V343, pd5928, DOI [DOI 10.1136/BMJ.D5928, 10.1136/bmj.d5928.22008217]
   Hunt H, 2018, SYST REV-LONDON, V7, DOI 10.1186/s13643-018-0695-8
   Jacobs JM, 2008, J GERONTOL B-PSYCHOL, V63, pS73, DOI 10.1093/geronb/63.2.S73
   Janssen I, 2020, APPL PHYSIOL NUTR ME, V45, pS248, DOI 10.1139/apnm-2020-0160
   Basterra-Gortari FJ, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.114.000864
   Josaphat KJ, 2019, OBESITY, V27, P362, DOI 10.1002/oby.22388
   Katzmarzyk PT, 2019, MED SCI SPORT EXER, V51, P1227, DOI 10.1249/MSS.0000000000001935
   Kehler DS, 2018, EXP GERONTOL, V114, P1, DOI 10.1016/j.exger.2018.10.010
   Kho ME, 2020, APPL PHYSIOL NUTR ME, V45, pS151, DOI 10.1139/apnm-2020-0564
   Lakerveld J, 2016, OBES REV, V17, P62, DOI 10.1111/obr.12381
   Lampit A, 2014, PLOS MED, V11, DOI 10.1371/journal.pmed.1001756
   LeBlanc AG., 2017, TRANSL J AM COLL SPO, V2 -, DOI [10.1249/TJX.0000000000000039, DOI 10.1249/TJX.0000000000000039]
   Lee S, 2015, ERGONOMICS, V58, P220, DOI 10.1080/00140139.2014.967311
   de Rezende LFM, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-333
   Mansoubi M, 2016, MED SCI SPORT EXER, V48, P720, DOI 10.1249/MSS.0000000000000802
   McLaughlin EC, 2020, APPL PHYSIOL NUTR ME, V45, pS180, DOI 10.1139/apnm-2020-0279
   Moher D, 2001, LANCET, V357, P1191, DOI 10.1016/S0140-6736(00)04337-3
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Neuhaus M, 2014, OBES REV, V15, P822, DOI 10.1111/obr.12201
   Nussbaumer-Streit B, 2020, J CLIN EPIDEMIOL, V118, P42, DOI 10.1016/j.jclinepi.2019.10.011
   O'Donoghue G, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-2841-3
   Pieper D, 2014, J CLIN EPIDEMIOL, V67, P368, DOI 10.1016/j.jclinepi.2013.11.007
   Prince SA, 2017, OBES REV, V18, P915, DOI 10.1111/obr.12529
   Prince SA, 2020, INT J BEHAV NUTR PHY, V17, DOI 10.1186/s12966-020-00938-3
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Ramalho André, 2018, Motri., V14, P73
   Ross R., CANADIAN 24 HOUR S2, V45, DOI [10.1139/apnm-2020-0467, DOI 10.1139/APNM-2020-0467]
   Rumschlag G, 2015, ACCIDENT ANAL PREV, V74, P145, DOI 10.1016/j.aap.2014.10.009
   Sampasa-Kanyinga H, 2018, ACTA PAEDIATR, V107, P694, DOI 10.1111/apa.14210
   Saunders TJ, 2018, SPORTS MED, V48, P2347, DOI 10.1007/s40279-018-0963-8
   Scottish Intercollegiate Guidelines Network (SIGN), CRIT APPR NOT CHECKL
   Shea BJ, 2017, BMJ-BRIT MED J, V358, DOI 10.1136/bmj.j4008
   Shrestha N, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010912.pub2
   Siegel Shannon R, 2009, Int J Exerc Sci, V2, P165
   Sui WY, 2019, APPL ERGON, V75, P27, DOI 10.1016/j.apergo.2018.09.002
   Teychenne M, 2011, INT J BEHAV MED, V17, P246, DOI 10.1007/s12529-010-9075-z
   Thomée S, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-66
   Thosar SS, 2014, CARDIOVASC ULTRASOUN, V12, DOI 10.1186/1476-7120-12-50
   Torbeyns T, 2014, SPORTS MED, V44, P1261, DOI 10.1007/s40279-014-0202-x
   Tremblay MS, 2017, INT J BEHAV NUTR PHY, V14, DOI 10.1186/s12966-017-0525-8
   Vallance JK, 2015, AM J HEALTH BEHAV, V39, P62, DOI 10.5993/AJHB.39.1.7
   van der Ploeg HP, 2012, ARCH INTERN MED, V172, P494, DOI 10.1001/archinternmed.2011.2174
   van Uffelen JGZ, 2010, AM J PREV MED, V39, P379, DOI 10.1016/j.amepre.2010.05.024
   Viswanathan M., 2013, ASSESSING RISK BIAS
   von Elm E, 2008, J CLIN EPIDEMIOL, V61, P344, DOI 10.2471/BLT.07.045120
   Wells GA., 2014, The Newcastle -Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta -analyses, DOI DOI 10.1007/S10654-010-9491-Z
   Wirth K, 2017, AGEING RES REV, V35, P87, DOI 10.1016/j.arr.2016.12.002
   Zhai L, 2015, BRIT J SPORT MED, V49, P705, DOI 10.1136/bjsports-2014-093613
NR 68
TC 254
Z9 263
U1 22
U2 164
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD OCT
PY 2020
VL 45
IS 10
SU 2
SI SI
BP S197
EP S217
DI 10.1139/apnm-2020-0272
PG 21
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA OH1XT
UT WOS:000582365100008
PM 33054341
OA Green Published, hybrid, Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Le, NA
   Farkas-Epperson, M
   Sweeney, ME
   Wilson, PWF
   Brown, WV
AF Ngoc-Anh Le
   Farkas-Epperson, Monica
   Sweeney, Mary Ellen
   Wilson, Peter W. F.
   Brown, W. Virgil
TI Effect of ABT-335 (fenofibric acid) on meal-induced oxidative stress in
   patients with metabolic syndrome
SO ATHEROSCLEROSIS
LA English
DT Article
DE ABT-335; Fenofibric acid; Metabolic syndrome; Postprandial lipemia;
   Oxidative susceptibility
ID POSTPRANDIAL LIPEMIA; LDL; HDL; ATHEROGENESIS; LIPOPROTEINS;
   CHOLESTEROL; PARAMETERS; INSULIN; PLASMA
AB Objective: Examine the effect of ABT-335 (fenofibric acid) on postprandial lipemia and susceptibility of plasma lipoproteins to Cu++-mediated oxidation in patients with metabolic syndrome.
   Methods and results: This is a randomized double-blind, placebo-controlled study with cross-over and includes a 4-week wash-out period between the two treatment periods. At the end of each 8-week treatment period, subjects were challenged with a standardized mixed meal followed by blood collection over the ensuing 6 h. Plasma lipoproteins were isolated by a combination of ultracentrifugation and FPLC for the continuous monitoring of conjugated dienes formation as an assessment of oxidative susceptibility. Fasting plasma TG was reduced by 20% (p < 0.0002) and there was a modest reduction in hsCRP (6.1%, p < 0.06). There was no change in either HDLc or LDLc in these subjects. Postprandial lipemia was reduced with ABT-335 as demonstrated by a 28.5% reduction (p < 0.0005) in incremental area under the curve for TG during the 6-h period after the meal challenge. Lag times for both fasting LDL (+16%) and postprandial LDL (+28%) were increased with the ABT-335 therapy, suggestive of reduced oxidative susceptibility. Co-incubation with autologous HDL did not reduced LDL oxidative susceptibility in these patients.
   Conclusion: ABT-335 therapy reduced fasting and postprandial triglycerides in patients with metabolic syndrome. Autologous HDL may be dysfunctional in these patients as co-incubation with HDL failed to reduce oxidative susceptibility of LDL. During ABT-335 therapy, LDL was less susceptible to Cu++ mediated oxidative modification, in spite of the lack of changes in LDLc levels. Published by Elsevier Ireland Ltd.
C1 [Ngoc-Anh Le; Farkas-Epperson, Monica; Wilson, Peter W. F.; Brown, W. Virgil] Atlanta VAMC, Biomarker Core Lab, Decatur, GA 30033 USA.
   [Ngoc-Anh Le; Sweeney, Mary Ellen; Wilson, Peter W. F.; Brown, W. Virgil] Emory Univ, Sch Med, Atlanta, GA USA.
   [Sweeney, Mary Ellen] Atlanta VAMC, Lipids Hypertens Clin, Decatur, GA 30033 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Atlanta VA Health Care System; Emory University; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); Atlanta VA
   Health Care System
RP Le, NA (corresponding author), Atlanta VAMC, Room 4A183,1670 Clairmont Rd, Decatur, GA 30033 USA.
EM anh.le@va.gov
RI Wilson, Peter/J-2455-2016
OI Le, Ngoc-Anh/0000-0002-2634-4798
FU Abbott; Abbott Park
FX This research is supported by an investigator-initiated research grant
   to N-AL from Abbott, Abbott Park, IL.
CR Assmann G, 2004, CIRCULATION, V109, P8, DOI 10.1161/01.CIR.0000131512.50667.46
   Bae J, 2001, ATHEROSCLEROSIS, V154, P475
   Bays HE, 2008, J CLIN LIPIDOL, V2, P426, DOI 10.1016/j.jacl.2008.10.001
   Beisswenger PJ, 2011, DIABETIC MED, V28, P1088, DOI 10.1111/j.1464-5491.2011.03324.x
   Chisolm GM, 2000, FREE RADICAL BIO MED, V28, P1815, DOI 10.1016/S0891-5849(00)00344-0
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   ESTERBAUER H, 1989, FREE RADICAL RES COM, V6, P67, DOI 10.3109/10715768909073429
   Farkas-Epperson M, 2012, CLIN LIPIDOL, V7, P49, DOI 10.2217/CLP.11.72
   Gaenzer H, 2001, CARDIOVASC RES, V52, P509, DOI 10.1016/S0008-6363(01)00427-8
   Genest J, 2000, J CARDIOVASC PHARM, V35, P164, DOI 10.1097/00005344-200001000-00022
   Gradek WQ, 2004, AM J CARDIOL, V93, P881, DOI 10.1016/j.amjcard.2003.12.028
   Guivarc'h PH, 2004, CLIN THER, V26, P1456, DOI 10.1016/j.clinthera.2004.09.015
   Hopps E, 2010, NUTR METAB CARDIOVAS, V20, P72, DOI 10.1016/j.numecd.2009.06.002
   Innis-Whitehouse W, 1998, J LIPID RES, V39, P679
   Jeyarajah EJ, 2006, CLIN LAB MED, V26, P847, DOI 10.1016/j.cll.2006.07.006
   Jones PH, 2009, ATHEROSCLEROSIS, V204, P208, DOI 10.1016/j.atherosclerosis.2008.09.027
   KARPE F, 1994, ATHEROSCLEROSIS, V106, P83, DOI 10.1016/0021-9150(94)90085-X
   Karpe F, 2002, ATHEROSCLEROSIS SUPP, V3, P41, DOI 10.1016/S1567-5688(01)00004-6
   La NA, 2000, METABOLISM, V49, P167
   Le NA, 2000, METABOLISM, V49, P1271, DOI 10.1053/meta.2000.9518
   Mohiuddin SM, 2009, AM HEART J, V157, P195, DOI 10.1016/j.ahj.2008.08.027
   Navab M, 2001, ARTERIOSCL THROM VAS, V21, P481, DOI 10.1161/01.ATV.21.4.481
   Rapp Richard J, 2002, Cardiol Rev, V10, P163, DOI 10.1097/00045415-200205000-00005
   Reilly MP, 2003, CIRCULATION, V108, P1546, DOI 10.1161/01.CIR.0000088846.10655.E0
   SIMPSON HS, 1990, ATHEROSCLEROSIS, V85, P193, DOI 10.1016/0021-9150(90)90111-U
   SYVANNE M, 1993, ARTERIOSCLER THROMB, V13, P286, DOI 10.1161/01.ATV.13.2.286
   Van Lenten BJ, 2001, CIRCULATION, V103, P2283
   VanLenten BJ, 1995, J CLIN INVEST, V96, P2758, DOI 10.1172/JCI118345
   Vega GL, 2003, AM J CARDIOL, V91, P956, DOI 10.1016/S0002-9149(03)00111-5
   von Eckardstein A, 2001, ARTERIOSCL THROM VAS, V21, P13, DOI 10.1161/01.ATV.21.1.13
   WEINTRAUB MS, 1987, J CLIN INVEST, V79, P1110, DOI 10.1172/JCI112926
   Westphal S, 2003, ATHEROSCLEROSIS, V171, P369, DOI 10.1016/j.atherosclerosis.2003.08.030
   Zeman M, 2002, ANN NY ACAD SCI, V967, P336
   ZILVERSMIT DB, 1979, CIRCULATION, V60, P473, DOI 10.1161/01.CIR.60.3.473
NR 34
TC 1
Z9 1
U1 0
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD DEC
PY 2013
VL 231
IS 2
BP 268
EP 273
DI 10.1016/j.atherosclerosis.2013.09.022
PG 6
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 259PB
UT WOS:000327537700017
PM 24267238
OA hybrid
DA 2025-06-11
ER

PT J
AU Kyrou, I
   Tsigos, C
AF Kyrou, Ioannis
   Tsigos, Constantine
TI Stress hormones: physiological stress and regulation of metabolism
SO CURRENT OPINION IN PHARMACOLOGY
LA English
DT Review
ID PITUITARY-ADRENAL AXIS; RECOMBINANT HUMAN INTERLEUKIN-6; TYPE-2
   DIABETES-MELLITUS; DEPRESSIVE SYMPTOMS; WEIGHT CHANGE; OBESITY; RISK;
   NEUROENDOCRINE; PATHOGENESIS; INFLAMMATION
AB Stress, defined as a state of threatened homeostasis, mobilizes a complex spectrum of adaptive physiologic and behavioral responses that aim to re-establish the challenged body homeostasis. The hypothalamic-pituitary-ad renal (HPA) axis and the sympathetic nervous system (SNS) constitute the main effector pathways of the stress system, mediating its adaptive functions. In western societies, indices of stress correlate with increasing rates of both obesity and metabolic syndrome which have reached epidemic proportions. Recent data indicate that chronic stress, associated with mild hypercortisolemia and prolonged SNS activation, favors accumulation of visceral fat and contributes to the clinical presentation of visceral obesity, type 2 diabetes, and related cardiometabolic complications. Reciprocally, obesity promotes a systemic low-grade inflammation state, mediated by increased adipokine secretion, which can chronically stimulate the stress system.
C1 [Kyrou, Ioannis] Univ Warwick, Warwick Med Sch, Clin Sci Res Inst, WISDEM,Univ Hosp Coventry & Warwickshire, Coventry CV2 2DX, W Midlands, England.
   [Tsigos, Constantine] YGEIA Hosp Athens, Athens 11528, Greece.
C3 University of Warwick; Hygeia Hospital
RP Kyrou, I (corresponding author), Univ Warwick, Warwick Med Sch, Clin Sci Res Inst, WISDEM,Univ Hosp Coventry & Warwickshire, Coventry CV2 2DX, W Midlands, England.
EM I.Kyrou@warwick.ac.uk; ctsigos@gmail.com
CR Adam TC, 2007, PHYSIOL BEHAV, V91, P449, DOI 10.1016/j.physbeh.2007.04.011
   ANAGNOSTIS P, 2009, J CLIN ENDOCRIN 0526
   Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   Anderson SE, 2006, ARCH PEDIAT ADOL MED, V160, P285, DOI 10.1001/archpedi.160.3.285
   Bamberger CM, 1996, ENDOCR REV, V17, P245, DOI 10.1210/er.17.3.245
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   Björntorp P, 2000, BRIT J NUTR, V83, pS49, DOI 10.1017/S0007114500000957
   Brunner EJ, 2007, AM J EPIDEMIOL, V165, P828, DOI 10.1093/aje/kwk058
   Carnethon MR, 2007, ARCH INTERN MED, V167, P802, DOI 10.1001/archinte.167.8.802
   Ceriello A, 2008, DIABETES-METAB RES, V24, P14, DOI 10.1002/dmrr.790
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Charmandari E, 2005, ANNU REV PHYSIOL, V67, P259, DOI 10.1146/annurev.physiol.67.040403.120816
   Chrousos GP, 2009, NAT REV ENDOCRINOL, V5, P374, DOI 10.1038/nrendo.2009.106
   Chrousos GP, 1998, ENDOCRINOLOGY, V139, P437, DOI 10.1210/endo.139.2.5857
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   Chrousos GP, 1998, J CLIN ENDOCR METAB, V83, P1842, DOI 10.1210/jc.83.6.1842
   CHROUSOS GP, 1995, NEW ENGL J MED, V332, P1351, DOI 10.1056/NEJM199505183322008
   CHROUSOS GP, 1992, JAMA-J AM MED ASSOC, V267, P1244, DOI 10.1001/jama.267.9.1244
   de Kloet ER, 2000, EUR J PHARMACOL, V405, P187, DOI 10.1016/S0014-2999(00)00552-5
   Degawa-Yamauchi M, 2005, OBES RES, V13, P662, DOI 10.1038/oby.2005.74
   Dimsdale JE, 2008, J AM COLL CARDIOL, V51, P1237, DOI 10.1016/j.jacc.2007.12.024
   Dostert A, 2004, CURR PHARM DESIGN, V10, P2807
   Everson-Rose SA, 2004, DIABETES CARE, V27, P2856, DOI 10.2337/diacare.27.12.2856
   GILBEY MP, 1993, BAILLIERE CLIN ENDOC, V7, P259, DOI 10.1016/S0950-351X(05)80177-6
   Golden SH, 2004, DIABETES CARE, V27, P429, DOI 10.2337/diacare.27.2.429
   Grippo AJ, 2009, STRESS, V12, P1, DOI 10.1080/10253890802046281
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Kvetnansky R, 2009, PHYSIOL REV, V89, P535, DOI 10.1152/physrev.00042.2006
   Kyrou I, 2006, ANN NY ACAD SCI, V1083, P77, DOI 10.1196/annals.1367.008
   LAMBERTS SWJ, 1984, J CLIN ENDOCR METAB, V58, P298, DOI 10.1210/jcem-58-2-298
   Li SS, 2009, JAMA-J AM MED ASSOC, V302, P179, DOI 10.1001/jama.2009.976
   Lustman PJ, 1998, ANN INTERN MED, V129, P613, DOI 10.7326/0003-4819-129-8-199810150-00005
   Matsuzawa Y, 2006, FEBS LETT, V580, P2917, DOI 10.1016/j.febslet.2006.04.028
   McEwen BS, 1998, ANN NY ACAD SCI, V840, P33, DOI 10.1111/j.1749-6632.1998.tb09546.x
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Mooy JM, 2000, DIABETES CARE, V23, P197, DOI 10.2337/diacare.23.2.197
   OCONNOR DB, 2008, HLTH PSYCHOL S, V27, pS31
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Putignano P, 2004, J ENDOCRINOL INVEST, V27, P969, DOI 10.1007/BF03347544
   Rocha VZ, 2009, NAT REV CARDIOL, V6, P399, DOI 10.1038/nrcardio.2009.55
   Rosmond R, 1998, J CLIN ENDOCR METAB, V83, P1853, DOI 10.1210/jc.83.6.1853
   Rozanski A, 1999, CIRCULATION, V99, P2192, DOI 10.1161/01.CIR.99.16.2192
   SELYE H, 1946, J CLIN ENDOCR METAB, V6, P117, DOI 10.1210/jcem-6-2-117
   Serlachius A, 2007, PHYSIOL BEHAV, V92, P548, DOI 10.1016/j.physbeh.2007.04.032
   Surwit RS, 2002, DIABETES CARE, V25, P30, DOI 10.2337/diacare.25.1.30
   Tsigos C, 1997, NEUROENDOCRINOLOGY, V66, P54, DOI 10.1159/000127219
   Tsigos C, 1997, J CLIN ENDOCR METAB, V82, P4167, DOI 10.1210/jc.82.12.4167
   Tsigos C, 2002, J PSYCHOSOM RES, V53, P865, DOI 10.1016/S0022-3999(02)00429-4
   Turnbull AV, 1999, PHYSIOL REV, V79, P1, DOI 10.1152/physrev.1999.79.1.1
   VALE W, 1981, SCIENCE, V213, P1394, DOI 10.1126/science.6267699
   VELDHUIS JD, 1990, J CLIN ENDOCR METAB, V71, P452, DOI 10.1210/jcem-71-2-452
   VICENNATI V, 2009, OBESITY         0319
   Wang Minghan, 2005, Nutr Metab (Lond), V2, P3, DOI 10.1186/1743-7075-2-3
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Wellen KE, 2003, J CLIN INVEST, V112, P1785, DOI 10.1172/JCI20514
   Wirtz PH, 2009, METABOLISM, V58, P30, DOI 10.1016/j.metabol.2008.08.003
NR 57
TC 266
Z9 329
U1 1
U2 52
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1471-4892
EI 1471-4973
J9 CURR OPIN PHARMACOL
JI Curr. Opin. Pharmacol.
PD DEC
PY 2009
VL 9
IS 6
BP 787
EP 793
DI 10.1016/j.coph.2009.08.007
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 528KX
UT WOS:000272445300017
PM 19758844
DA 2025-06-11
ER

PT J
AU Park, S
   Quinn, L
   Park, CG
   Collins, E
   Hong, OS
   Ferrans, CE
AF Park, Sungwon
   Quinn, Lauretta
   Park, Chang Gi
   Collins, Eileen
   Hong, Oi Saeng
   Ferrans, Carol Estwing
TI Health Behavior Adherence in a Metropolitan-Based Metabolic Syndrome
   Management Program during the COVID-19 Pandemic
SO JOURNAL OF OBESITY & METABOLIC SYNDROME
LA English
DT Article
DE Metabolic syndrome; Health behavior; Disease management; Guideline
   adherence; Republic of Korea
ID LIFE-STYLE FACTORS; SOCIOECONOMIC-STATUS; ASSOCIATION; RISK; WORKING;
   ADULTS
AB Background: The COVID-19 pandemic increased the worldwide prevalence of metabolic syndrome. The purpose of this study was to assess health behavior adherence during the pandemic in adults who had engaged in a metabolic syndrome management program for at least 6 months. This assessment included an evaluation of health behavior changes, factors influencing adherence, and clinical parameters. The city-wide program was operated by the Seoul Metropolitan Government. Methods: Baseline and follow-up data were compared in 116 participants who engaged in the program for at least 6 months prior to the pandemic. Health behaviors and clinical parameters were examined. Generalized estimating equation analysis was used to identify sociodemographic variables influencing health behavior adherence over time. Results: Systolic blood pressure, waist circumference, and blood glucose improved (all P<0.05), and risk factors decreased (P<0.001) from baseline to follow-up (mean +/- standard deviation, 1.13 +/- 0.91 years). All six health behaviors, physical activity and weight control, eating habits, alcohol consumption and smoking, stress management, sleep and rest, and medication compliance and medical examination improved (all P<0.001) from baseline to follow-up (2.37 +/- 1.05 years). Smoking and employment negatively influenced adherence to health behaviors (P<0.05). Participants felt the most beneficial part of the program was receiving sequential medical examination results with follow-up consultations by public health professionals without charge. Conclusion: Our study demonstrated the durability of the impact of the Seoul Program on all six targeted health behaviors as well as clinical parameters. Findings encourage participation in such broad-based programs and development of novel approaches to facilitate success for smokers and employed participants.
C1 [Park, Sungwon] Univ Michigan, Sch Nursing, Dept Hlth Behav & Biol Sci, 400 North Ingalls St, Ann Arbor, MI 48109 USA.
   [Quinn, Lauretta; Park, Chang Gi; Collins, Eileen; Ferrans, Carol Estwing] Univ Illinois, Coll Nursing, Chicago, IL USA.
   [Hong, Oi Saeng] Univ Calif San Francisco, Sch Nursing, Occupat & Environm Hlth Nursing Grad Program, San Francisco, CA USA.
C3 University of Michigan System; University of Michigan; University of
   Illinois System; University of Illinois Chicago; University of Illinois
   Chicago Hospital; University of California System; University of
   California San Francisco
RP Park, S (corresponding author), Univ Michigan, Sch Nursing, Dept Hlth Behav & Biol Sci, 400 North Ingalls St, Ann Arbor, MI 48109 USA.
EM sungwonp@umich.edu
RI Park, Chang/AEN-4164-2022
FU American Association of Occupational Health Nurses Foundation Medique
   New Researcher Grant; Sigma Alpha Lambda Chapter Award, Alpha Lambda
   Chapter of Sigma Theta Tau Honor Society of Nursing; Sherri Mendelson
   Student Research Award, College of Nursing, University of Illinois at
   Chicago (UIC); Award for Graduate Research from UIC Graduate College;
   Global Korean Nursing Foundation USA scholarship award
FX This study was funded by the 2021 American Association of Occupational
   Health Nurses Foundation Medique New Researcher Grant; the 2021 Sigma
   Alpha Lambda Chapter Award, Alpha Lambda Chapter of Sigma Theta Tau
   Honor Society of Nursing; the 2020-2021 Tom and Sherri Mendelson Student
   Research Award, College of Nursing, University of Illinois at Chicago
   (UIC) ; the Award for Graduate Research from UIC Graduate College; and
   the 2020 Global Korean Nursing Foundation USA scholarship award. In
   addition, the authors appreciate all participants in the study.
CR 강세원, 2010, [The Journal of Fundamentals of Nursing, 기본간호학회지], V17, P487
   [Anonymous], 2019, See Seoul citizen metabolic syndrome at a glance
   Auriemma RS, 2021, J ENDOCRINOL INVEST, V44, P2845, DOI 10.1007/s40618-021-01563-y
   Center Disaster and Safety Countermeasure Headquarters, 2020, Basic guidelines for distancing in daily life Internet
   Centers for Disease Control and Prevention, 2022, About the national DPP Internet
   Choo J, 2016, INT J ENV RES PUB HE, V13, DOI 10.3390/ijerph13070667
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Coskun MG, 2022, NUTRIENTS, V14, DOI 10.3390/nu14194006
   DPP Res Grp, 2002, DIABETES CARE, V25, P2165
   Fisher WA, 2003, BLACKW SER HLTH PSYC, P82, DOI 10.1002/9780470753552.ch4
   Ham D, 2020, NUTR RES PRACT, V14, P621, DOI 10.4162/nrp.2020.14.6.621
   Cho HH, 2021, BRIT J NUTR, V126, P685, DOI 10.1017/S0007114520004535
   Johnson P, 2015, WORKPLACE HEALTH SAF, V63, P245, DOI 10.1177/2165079915576920
   Kim Young Ok, 2002, Preventive Nutrition and Food Science, V7, P442
   Korean National Health Insurance Service, 2022, Health screenings statistical yearbook in 2021 Internet
   Lee JA, 2017, J PUBLIC HEALTH-UK, V39, P82, DOI 10.1093/pubmed/fdv208
   Liu Y, 2017, J AFFECT DISORDERS, V217, P190, DOI 10.1016/j.jad.2017.04.009
   Marhl M, 2020, DIABETES METAB SYND, V14, P671, DOI 10.1016/j.dsx.2020.05.013
   Mirmiran P, 2021, NUTR J, V20, DOI 10.1186/s12937-021-00728-y
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   Park M S., 2017, Public Health Affairs, V1, P25, DOI DOI 10.29339/PHA.1.1.25
   Park SS, 2010, Food Ind Nutr, V15, P10
   Park S, 2022, NURS RES, V71, P275, DOI 10.1097/NNR.0000000000000587
   Rahimi K, 2021, LANCET, V397, P1625, DOI 10.1016/S0140-6736(21)00590-0
   Ryder M, 2023, J NURS SCHOLARSHIP, V55, P154, DOI 10.1111/jnu.12835
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Santana Amalia Ivine Costa, 2020, Rev Bras Med Trab, V18, P185, DOI 10.47626/1679-4435-2020-511
   Seoul Metropolitan Government, 2018, Report No. Health and Medical Policy Division-9761
   Sohn M, 2021, J OBES METAB SYNDR, V30, P248
   Tison GH, 2022, LANCET GLOB HEALTH, V10, pE1381, DOI 10.1016/S2214-109X(22)00361-8
   van Namen M, 2019, METABOLISM, V101, DOI 10.1016/j.metabol.2019.153988
   Verweij LM, 2013, PUBLIC HEALTH NUTR, V16, P281, DOI 10.1017/S1368980012002741
   Yang XJ, 2021, NUTR METAB CARDIOVAS, V31, P2792, DOI 10.1016/j.numecd.2021.06.007
   Ying XH, 2021, BMC PUBLIC HEALTH, V21, DOI 10.1186/s12889-021-12074-z
NR 34
TC 1
Z9 1
U1 0
U2 1
PU KOREAN SOC STUDY OBESITY
PI SEOUL
PA RENAISSANCE TOWER, 1010  14 MALLIJAE-RO, MAPO-GU, SEOUL, 04195, SOUTH
   KOREA
SN 2508-6235
EI 2508-7576
J9 J OBES METAB SYNDR
JI J. Obes. Metab. Syndr.
PD JUN
PY 2024
VL 33
IS 2
BP 166
EP 176
DI 10.7570/jomes23039
PG 11
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA D3A0L
UT WOS:001294933500008
PM 38253358
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cheng, HS
   Ton, SH
   Tan, JBL
   Kadir, KA
AF Cheng, Hong Sheng
   Ton, So Ha
   Tan, Joash Ban Lee
   Kadir, Khalid Abdul
TI The Ameliorative Effects of a Tocotrienol-Rich Fraction on the AGE-RAGE
   Axis and Hypertension in High-Fat-Diet-Fed Rats with Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE advanced glycation end product; cholesterol; hepatic steatosis;
   myeloperoxidase; peroxisome proliferator-activated receptor; vitamin E
ID HMG-COA REDUCTASE; NATURAL VITAMIN-E; BLOOD-PRESSURE; PALM OIL;
   INSULIN-SENSITIVITY; DIABETIC-PATIENTS; OXIDATIVE STRESS;
   ACID-METABOLISM; CLINICAL-TRIAL; DOUBLE-BLIND
AB The clinical value of tocotrienols is increasingly appreciated because of the unique therapeutic effects that are not shared by tocopherols. However, their effect on metabolic syndrome is not well-established. This study aimed to investigate the effects of a tocotrienol-rich fraction (TRF) from palm oil in high-fat-diet-treated rats. Male, post-weaning Sprague Dawley rats were provided high-fat (60% kcal) diet for eight weeks followed by a TRF (60 mg/kg) treatment for another four weeks. Physical, metabolic, and histological changes were compared to those on control and high-fat diets respectively. High-fat feeding for eight weeks induced all hallmarks of metabolic syndrome. The TRF reversed systolic and diastolic hypertension, hypercholesterolemia, hepatic steatosis, impaired antioxidant defense, and myeloperoxidase hyperactivity triggered by the high-fat diet. It also conferred an inhibitory effect on protein glycation to reduce glycated hemoglobin A1c and advanced glycation end products (AGE). This was accompanied by the suppression of the receptor for advanced glycation end product (RAGE) expression in the liver. The treatment effects on visceral adiposity, glycemic control, triglyceride level, as well as peroxisome proliferator-activated receptor and expression were negligible. To conclude, treatment with a TRF exhibited protective effects on the cardiovascular and liver health in addition to the amelioration of plasma redox imbalance and AGE-RAGE activation. Further investigation as a therapy for metabolic syndrome is therefore worthwhile.
C1 [Cheng, Hong Sheng; Ton, So Ha; Tan, Joash Ban Lee] Monash Univ Malaysia, Sch Sci, Bandar Sunway 46150, Selangor, Malaysia.
   [Kadir, Khalid Abdul] Monash Univ Malaysia, Sch Med & Hlth Sci, Bandar Sunway 46150, Selangor, Malaysia.
C3 Monash University; Monash University Malaysia; Monash University; Monash
   University Malaysia
RP Cheng, HS (corresponding author), Monash Univ Malaysia, Sch Sci, Bandar Sunway 46150, Selangor, Malaysia.
EM hong.cheng@monash.edu; ton.soha2016@gmail.com; tan.ban.lee@monash.edu;
   khalid.kadir@monash.edu
RI Cheng, Hong Sheng/AAD-6121-2019
OI Cheng, Hong Sheng/0000-0001-9745-7872
FU Ministry of Science, Technology and Innovation, Malaysia (MOSTI)
   [02-02-10-SF0249]; School of Science, Monash University Malaysia
FX The work was funded by the Ministry of Science, Technology and
   Innovation, Malaysia (MOSTI grant: 02-02-10-SF0249) and an internal
   grant from the School of Science, Monash University Malaysia. We would
   like to express our deepest gratitude to Andrew Leong Kum Loong and
   Zulkhaili Zainal Abidin for their assistance in animal handling.
CR Adachi H, 2000, J GERONTOL A-BIOL, V55, pB280, DOI 10.1093/gerona/55.6.B280
   Aggarwal BB, 2010, BIOCHEM PHARMACOL, V80, P1613, DOI 10.1016/j.bcp.2010.07.043
   Ahmad NS, 2005, CLIN EXP PHARMACOL P, V32, P761, DOI 10.1111/j.1440-1681.2005.04264.x
   Ahsan H, 2014, NUTR METAB, V11, DOI 10.1186/1743-7075-11-52
   Baliarsingh S, 2005, ATHEROSCLEROSIS, V182, P367, DOI 10.1016/j.atherosclerosis.2005.02.020
   Baynes JW, 1999, DIABETES, V48, P1, DOI 10.2337/diabetes.48.1.1
   Budin SB, 2009, CLINICS, V64, P235, DOI 10.1590/S1807-59322009000300015
   Chen X, 2001, HYPERTENSION, V38, P606, DOI 10.1161/hy09t1.094005
   Chin SF, 2008, NUTRITION, V24, P1, DOI 10.1016/j.nut.2007.08.006
   Chin SF, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-42
   Cicero AFG, 2015, NUTR J, V14, DOI 10.1186/s12937-015-0019-y
   Fang F, 2010, MOL NUTR FOOD RES, V54, P345, DOI 10.1002/mnfr.200900119
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   GOULD MN, 1991, AM J CLIN NUTR, V53, pS1068, DOI 10.1093/ajcn/53.4.1068S
   Hoggatt AF, 2010, J AM ASSOC LAB ANIM, V49, P329
   Jain SK, 1997, FREE RADICAL BIO MED, V22, P593, DOI 10.1016/S0891-5849(96)00377-2
   Jiang Q, 2014, FREE RADICAL BIO MED, V72, P76, DOI 10.1016/j.freeradbiomed.2014.03.035
   Karakas M, 2012, CURR ATHEROSCLER REP, V14, P277, DOI 10.1007/s11883-012-0242-3
   Kataoka Y, 2014, ATHEROSCLEROSIS, V232, P377, DOI 10.1016/j.atherosclerosis.2013.11.075
   Kersten S, 1999, J CLIN INVEST, V103, P1489, DOI 10.1172/JCI6223
   Khanna S, 2006, J NEUROCHEM, V98, P1474, DOI 10.1111/j.1471-4159.2006.04000.x
   KHOR HT, 1995, NUTR RES, V15, P537, DOI 10.1016/0271-5317(95)00021-6
   KOBA K, 1992, BIOSCI BIOTECH BIOCH, V56, P1420, DOI 10.1271/bbb.56.1420
   Kuhad A, 2009, LIFE SCI, V84, P296, DOI 10.1016/j.lfs.2008.12.014
   Levy JC, 1998, DIABETES CARE, V21, P2191, DOI 10.2337/diacare.21.12.2191
   Li FJ, 2010, ATHEROSCLEROSIS, V211, P278, DOI 10.1016/j.atherosclerosis.2010.01.015
   Magosso E, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-166
   Matough Fatmah A, 2014, Sultan Qaboos Univ Med J, V14, pe95
   Müller L, 2010, MOL NUTR FOOD RES, V54, P731, DOI 10.1002/mnfr.200900399
   Muharis SP, 2010, NUTR RES, V30, P209, DOI 10.1016/j.nutres.2010.03.005
   Muto C, 2013, J CLIN BIOCHEM NUTR, V52, P32, DOI 10.3164/jcbn.12-97
   Nesaretnam K, 2012, GENES NUTR, V7, P3, DOI 10.1007/s12263-011-0224-z
   PARKER RA, 1993, J BIOL CHEM, V268, P11230
   Parlee SD, 2014, METHOD ENZYMOL, V537, P93, DOI 10.1016/B978-0-12-411619-1.00006-9
   PEARCE BC, 1992, J MED CHEM, V35, P3595, DOI 10.1021/jm00098a002
   Pryor WA, 2000, FREE RADICAL BIO MED, V28, P141, DOI 10.1016/S0891-5849(99)00224-5
   Qureshi AA, 2002, ATHEROSCLEROSIS, V161, P199, DOI 10.1016/S0021-9150(01)00619-0
   Qureshi AA, 2001, J NUTR, V131, P2606, DOI 10.1093/jn/131.10.2606
   Rasool AHG, 2006, J NUTR SCI VITAMINOL, V52, P473, DOI 10.3177/jnsv.52.473
   Reeves PG, 1997, J NUTR, V127, pS838
   Ricciarelli R, 2007, MOL ASPECTS MED, V28, P591, DOI 10.1016/j.mam.2007.01.004
   Sen CK, 2007, VITAM HORM, V76, P203, DOI 10.1016/S0083-6729(07)76008-9
   Siddiqui S, 2010, CHEM-BIOL INTERACT, V188, P651, DOI 10.1016/j.cbi.2010.08.010
   Siti Balkis B., 2011, J BASIC APPL SCI, V5, P2367
   Song J, 2004, AM J PHYSIOL-RENAL, V287, pF1204, DOI 10.1152/ajprenal.00063.2004
   Svingen T, 2015, PEERJ, V3, DOI 10.7717/peerj.855
   Taridi NM, 2011, CLIN TER, V162, P93
   Tiwari V, 2009, PHARMACOL BIOCHEM BE, V93, P183, DOI 10.1016/j.pbb.2009.05.009
   Vafa M, 2015, J RES MED SCI, V20, P540, DOI 10.4103/1735-1995.165945
   Vasdev S, 2002, MOL CELL BIOCHEM, V238, P111, DOI 10.1023/A:1019915306581
   Wan Nazaimoon W M, 2002, Malays J Pathol, V24, P77
   Wong WY, 2017, EUR J NUTR, V56, P133, DOI 10.1007/s00394-015-1064-1
   Wong WY, 2012, NUTRIENTS, V4, P1527, DOI 10.3390/nu4101527
   Wu N, 2013, BBA-MOL BASIS DIS, V1832, P1560, DOI 10.1016/j.bbadis.2013.04.024
NR 54
TC 23
Z9 24
U1 1
U2 16
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2017
VL 9
IS 9
AR 984
DI 10.3390/nu9090984
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FI4UM
UT WOS:000411973200067
PM 28880217
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Westerink, J
   Hajer, GR
   Kranendonk, MEG
   Schipper, HS
   Monajemi, H
   Kalkhoven, E
   Visseren, FLJ
AF Westerink, Jan
   Hajer, Gideon R.
   Kranendonk, Mariette E. G.
   Schipper, Henk S.
   Monajemi, Houshang
   Kalkhoven, Eric
   Visseren, Frank L. J.
TI An Oral Mixed Fat Load Is Followed by a Modest Anti-inflammatory
   Adipocytokine Response in Overweight Patients with Metabolic Syndrome
SO LIPIDS
LA English
DT Article
DE Postprandial; Cytokines; Adipocytokines; Metabolic syndrome
ID ACYLATION-STIMULATING PROTEIN; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; ENDOTHELIAL FUNCTION; OXIDATIVE STRESS;
   ADIPONECTIN; INFLAMMATION; OBESE; MEAL; GLUCOSE
AB We investigated the postprandial changes in plasma levels of adipocytokines in overweight patients with metabolic syndrome after an oral fat load. After an oral fat load and during a prolonged fast, blood was drawn at 0, 2, 3, 4 and 8 h for measurement of adiponectin, adipsin, cathepsin S, chemerin, hepatic growth factor, interferon-gamma-inducible protein-10, leptin, macrophage chemoattractant protein-1, macrophage migration inhibitory factor, nerve growth factor, retinol binding protein-4, resistin, serum amyloid A1, tissue inhibitor of metalloproteinase-1 and thrombopoietin using a microbead-based Luminex assay. Area under the curves (AUC) were calculated and compared. Plasma adiponectin levels were higher after an oral fat load compared to fasting at t = 2 h (950 +/- A 513 vs. -1,881 +/- A 713 ng/ml) while the plasma levels for adipsin (-9 +/- A 5 vs. 16 +/- A 5 ng/ml), chemerin (-122 +/- A 35 vs. 13 +/- A 21 ng/ml), SAA-1 (-391 +/- A 213 vs. 522 +/- A 173 ng/ml) and TPO (-335 +/- A 144 vs. 622 +/- A 216 ng/ml) were lower after an oral fat load compared to fasting. The baseline corrected AUC for IP-10 was higher after fat load compared to fasting (median -116 pg h/ml; IQR -270 to 10 vs. -21 pg h/ml; IQR -136 to 418 (p = 0.047). In conclusion, in overweight male subjects with the metabolic syndrome, an oral fat load is accompanied with a modest anti-inflammatory response of adipose tissue-derived adipocytokines.
C1 [Westerink, Jan; Hajer, Gideon R.; Kranendonk, Mariette E. G.; Monajemi, Houshang; Visseren, Frank L. J.] Univ Med Ctr Utrecht, Dept Vasc Med, NL-3508 GA Utrecht, Netherlands.
   [Schipper, Henk S.; Kalkhoven, Eric] Univ Med Ctr Utrecht, Dept Metab Dis, Utrecht, Netherlands.
   [Schipper, Henk S.] Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Dept Pediat Immunol & Infect Dis, Utrecht, Netherlands.
C3 Utrecht University; Utrecht University Medical Center; Utrecht
   University; Utrecht University Medical Center; Wilhelmina
   Kinderziekenhuis; Utrecht University; Utrecht University Medical Center
RP Westerink, J (corresponding author), Univ Med Ctr Utrecht, Dept Vasc Med, POB 85500, NL-3508 GA Utrecht, Netherlands.
EM j.westerink-3@umcutrecht.nl; F.L.J.Visseren@umcutrecht.nl
RI Westerink, Jan/AAO-7725-2021; Visseren, Frank/I-4855-2013; Schipper,
   Henk/JFJ-5493-2023
OI Visseren, Frank/0000-0003-3951-5223; Schipper, Henk/0000-0003-1997-8060
CR Agarwal SK, 2001, J INTERF CYTOK RES, V21, P147, DOI 10.1089/107999001750133159
   Annuzzi G, 2010, METABOLISM, V59, P567, DOI 10.1016/j.metabol.2009.08.020
   Boden G, 2002, EUR J CLIN INVEST, V32, P14, DOI 10.1046/j.1365-2362.32.s3.3.x
   Carlson JJ, 2009, NUTR METAB, V6, DOI 10.1186/1743-7075-6-32
   Ceriello A, 2005, CIRCULATION, V111, P2518, DOI 10.1161/01.CIR.0000165070.46111.9F
   Ceriello A, 2004, DIABETES, V53, P701, DOI 10.2337/diabetes.53.3.701
   Cianflone K, 2004, J LIPID RES, V45, P124, DOI 10.1194/jlr.M300214-JLR200
   Cianflone K, 2003, BBA-BIOMEMBRANES, V1609, P127, DOI 10.1016/S0005-2736(02)00686-7
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cuda C, 2011, METABOLISM, V60, P1131, DOI 10.1016/j.metabol.2010.12.006
   Derosa G, 2010, MICROVASC RES, V80, P110, DOI 10.1016/j.mvr.2010.03.012
   DODT C, 1994, EXP CLIN ENDOCRINOL, V102, P460, DOI 10.1055/s-0029-1211320
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   El Khoury D, 2010, ATHEROSCLEROSIS, V210, P307, DOI 10.1016/j.atherosclerosis.2009.11.017
   English PJ, 2003, OBES RES, V11, P839, DOI 10.1038/oby.2003.115
   Ernst MC, 2010, TRENDS ENDOCRIN MET, V21, P660, DOI 10.1016/j.tem.2010.08.001
   Erridge C, 2009, ARTERIOSCL THROM VAS, V29, P1944, DOI 10.1161/ATVBAHA.109.194050
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   Ge Q, 2011, AM J PHYSIOL-ENDOC M, V301, pE326, DOI 10.1152/ajpendo.00153.2011
   Hajer GR, 2008, CLIN ENDOCRINOL, V69, P870, DOI 10.1111/j.1365-2265.2008.03250.x
   Hajer GR, 2009, ATHEROSCLEROSIS, V202, P216, DOI 10.1016/j.atherosclerosis.2008.04.035
   Hansen K, 1997, AM J PHYSIOL-REG I, V273, pR548, DOI 10.1152/ajpregu.1997.273.2.R548
   Herder C, 2007, INT J OBESITY, V31, P403, DOI 10.1038/sj.ijo.0803432
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Karki S, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0028146
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   LUSTER AD, 1987, J EXP MED, V166, P1084, DOI 10.1084/jem.166.4.1084
   Nowotny B, 2010, HORM METAB RES, V42, P746, DOI 10.1055/s-0030-1261924
   Olijhoek JK, 2008, J CARDIOVASC PHARM, V52, P145, DOI 10.1097/FJC.0b013e31817ffe76
   Poppitt SD, 2008, NUTRITION, V24, P322, DOI 10.1016/j.nut.2007.12.012
   Ritchie SA, 2007, NUTR METAB CARDIOVAS, V17, P319, DOI 10.1016/j.numecd.2006.07.005
   Rubin D, 2008, BRIT J NUTR, V99, P76, DOI 10.1017/S0007114507791857
   Schaeffler A, 2009, IMMUNOLOGY, V126, P233, DOI 10.1111/j.1365-2567.2008.02892.x
   Schipper HS, 2010, CLIN CHEM, V56, P1320, DOI 10.1373/clinchem.2010.146118
   Shi H, 2006, J CLIN INVEST, V116, P3015, DOI 10.1172/JCI28898
   Shimabukuro M, 2007, AM J CLIN NUTR, V86, P923, DOI 10.1093/ajcn/86.4.923
   Song MJ, 2006, BIOCHEM BIOPH RES CO, V346, P739, DOI 10.1016/j.bbrc.2006.05.170
   Wassink AMJ, 2007, EUR J CLIN INVEST, V37, P8, DOI 10.1111/j.1365-2362.2007.01755.x
   WHITE RT, 1992, J BIOL CHEM, V267, P9210
   Winer DA, 2011, NAT MED, V17, P610, DOI 10.1038/nm.2353
   Yamauchi J, 2008, METABOLISM, V57, P149, DOI 10.1016/j.metabol.2007.08.018
NR 41
TC 9
Z9 10
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0024-4201
EI 1558-9307
J9 LIPIDS
JI Lipids
PD MAR
PY 2014
VL 49
IS 3
BP 247
EP 254
DI 10.1007/s11745-014-3877-8
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA AC6WF
UT WOS:000332665600004
PM 24445379
DA 2025-06-11
ER

PT J
AU Min, SH
   Docherty, SL
   Im, EO
   Hu, X
   Hatch, D
   Yang, Q
AF Min, Se Hee
   Docherty, Sharron L.
   Im, Eun-Ok
   Hu, Xiao
   Hatch, Daniel
   Yang, Qing
TI Identification of high-risk symptom cluster burden group among midlife
   peri-menopausal and post-menopausal women with metabolic syndrome using
   latent class growth analysis
SO WOMENS HEALTH
LA English
DT Article
DE menopause; midlife; symptom; women
ID QUALITY-OF-LIFE; DEPRESSIVE SYMPTOMS; TRAJECTORIES; TRANSITION; HEALTH;
   PREVALENCE; PERIMENOPAUSAL; VASOMOTOR; STRESS
AB Background:Midlife peri-menopausal and post-menopausal women with metabolic syndrome experience multiple co-occurring symptoms or symptom clusters, which often result in significant symptom cluster burden. While they are a high-risk symptom burden group, there are no studies that have focused on identifying symptom cluster trajectories in midlife peri-menopausal and post-menopausal women with metabolic syndrome. Objectives:The objectives were to identify meaningful subgroups of midlife peri-menopausal and post-menopausal women with metabolic syndrome based on their distinct symptom cluster burden trajectories, and to describe the demographic, social, and clinical characteristics of different symptom cluster burden subgroups. Design:This is a secondary data analysis using the longitudinal data from Study of Women's Health Across the Nation. Methods:Multi-trajectory analysis using latent class growth analysis was conducted to join the different developmental trajectories of symptom clusters to identify meaningful subgroups and high-risk subgroup for greater symptom cluster burden over time. Then, descriptive statistics were used to explain the demographic characteristics of each symptom cluster trajectory subgroup, and bivariate analysis to examine the association between each symptom cluster trajectory subgroup and demographic characteristics. Results:A total of four classes were identified: Class 1 (low symptom cluster burden), Classes 2 and 3 (moderate symptom cluster burden), and Class 4 (high symptom cluster burden). Social support was a significant predictor of high symptom cluster burden subgroup and highlights the need to provide routine assessment. Conclusion:An understanding and appreciation for the different symptom cluster trajectory subgroups and their dynamic nature will assist clinicians to offer targeted and routine symptom cluster assessment and management in clinical settings.
C1 [Min, Se Hee] Columbia Univ, Sch Nursing, New York, NY USA.
   [Docherty, Sharron L.; Hatch, Daniel; Yang, Qing] Duke Univ, Sch Nursing, Durham, NC USA.
   [Im, Eun-Ok; Hu, Xiao] Emory Univ, Nell Hodgson Woodruff Sch Nursing, Atlanta, GA USA.
   [Min, Se Hee] Columbia Univ, Sch Nursing, 560 W 168th St, New York, NY 10032 USA.
C3 Columbia University; Duke University; Emory University; Columbia
   University
RP Min, SH (corresponding author), Columbia Univ, Sch Nursing, 560 W 168th St, New York, NY 10032 USA.
EM sm4394@cumc.columbia.edu
RI Hu, Xiaoyu/AAO-2060-2020
OI Yang, Qing/0000-0003-4844-4690; Min, Se Hee/0000-0003-2722-6627
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Alshraifeen A, 2020, NURS OPEN, V7, P1517, DOI 10.1002/nop2.533
   Atkins JH, 2010, AIDS CARE, V22, P793, DOI 10.1080/09540120903482994
   Bentley-Lewis R, 2007, NAT CLIN PRACT ENDOC, V3, P696, DOI 10.1038/ncpendmet0616
   Bo S, 2007, J GEN INTERN MED, V22, P1695, DOI 10.1007/s11606-007-0399-6
   Bromberger JT, 2011, PSYCHOL MED, V41, P1879, DOI 10.1017/S003329171100016X
   Bromberger JT, 2007, J AFFECT DISORDERS, V103, P267, DOI 10.1016/j.jad.2007.01.034
   Cao J, 2021, ISSUES MENT HEALTH N, V42, P989, DOI 10.1080/01612840.2021.1919806
   Carr MC, 2003, J CLIN ENDOCR METAB, V88, P2404, DOI 10.1210/jc.2003-030242
   Ceylan B, 2014, CLIMACTERIC, V17, P705, DOI 10.3109/13697137.2014.929108
   Fanti K.A., 2014, Annals of Depression and Anxiety, V1, P1
   Ferrara CM, 2002, J CLIN ENDOCR METAB, V87, P4166, DOI 10.1210/jc.2001-012034
   Furihata R, 2018, J AFFECT DISORDERS, V234, P156, DOI 10.1016/j.jad.2018.02.093
   Greene T, 2017, J AFFECT DISORDERS, V220, P24, DOI 10.1016/j.jad.2017.05.036
   Guérin E, 2017, ARCH WOMEN MENT HLTH, V20, P733, DOI 10.1007/s00737-017-0755-4
   Hall MH, 2012, SLEEP, V35, P783, DOI 10.5665/sleep.1874
   Han TS., 2015, Medicine, V43, P80, DOI DOI 10.1016/J.MPMED.2014.11.006
   Harlow Sioban D, 2017, Womens Midlife Health, V3, DOI 10.1186/s40695-017-0021-y
   Harlow Sioban D, 2015, Womens Midlife Health, V1, P5, DOI 10.1186/s40695-015-0006-7
   Hockenberry MJ, 2017, J PAIN SYMPTOM MANAG, V54, P1, DOI 10.1016/j.jpainsymman.2017.03.002
   ICPSR, WEB PAGES
   Jakobsen JC, 2017, BMC MED RES METHODOL, V17, DOI 10.1186/s12874-017-0442-1
   Jones BL, 2007, SOCIOL METHOD RES, V35, P542, DOI 10.1177/0049124106292364
   Kang SH, 2011, GUT LIVER, V5, P472, DOI 10.5009/gnl.2011.5.4.472
   Kravitz Howard M, 2017, Curr Sleep Med Rep, V3, P235, DOI 10.1007/s40675-017-0084-1
   Kwasniewska Magdalena, 2009, Central European Journal of Public Health, V17, P14
   Lampousi AM, 2021, J BEHAV MED, V44, P622, DOI 10.1007/s10865-021-00216-y
   Lee C, 2021, J CARDIOVASC NURS, V36, pE80, DOI 10.1097/JCN.0000000000000850
   Marc Janja, 2007, EJIFCC, V18, P7
   Miaskowski C, 2017, JNCI-J NATL CANCER I, V109, DOI 10.1093/jnci/djw253
   Miaskowski C, 2016, SEMIN ONCOL NURS, V32, P405, DOI 10.1016/j.soncn.2016.08.006
   Miley-Akerstedt A, 2018, DEMENT GER COGN D EX, V8, P439, DOI 10.1159/000493749
   Min SH, 2022, NURS RES, V71, pE28, DOI 10.1097/NNR.0000000000000591
   Oladejo A O, 2011, Ann Ib Postgrad Med, V9, P78
   Parker KP, 2005, J NURS SCHOLARSHIP, V37, P209, DOI 10.1111/j.1547-5069.2005.00037.x
   Randolph JF, 2004, J CLIN ENDOCR METAB, V89, P1555, DOI 10.1210/jc.2003-031183
   Reeves AN, 2021, ANN EPIDEMIOL, V58, P48, DOI 10.1016/j.annepidem.2021.02.011
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Ruan XY, 2017, J PSYCHOSOM OBST GYN, V38, P161, DOI 10.1080/0167482X.2016.1244181
   Salas AS, 2019, SUPPORT CARE CANCER, V27, P4733, DOI 10.1007/s00520-019-04726-z
   Steenkamp MM, 2012, J TRAUMA STRESS, V25, P469, DOI 10.1002/jts.21718
   Tepper PG, 2016, MENOPAUSE, V23, P1067, DOI 10.1097/GME.0000000000000676
   Thomas Annette Joan, 2018, Womens Midlife Health, V4, P8, DOI 10.1186/s40695-018-0039-9
   Torréns JI, 2009, MENOPAUSE, V16, P257, DOI 10.1097/gme.0b013e318185e249
   van der Vaart CH, 2007, UROLOGY, V69, P691, DOI 10.1016/j.urology.2007.01.017
   Woods Nancy Fugate, 2005, Am J Med, V118 Suppl 12B, P14
   Yamaoka K, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-138
   Zeleke BM, 2016, FERTIL STERIL, V105, P149, DOI 10.1016/j.fertnstert.2015.09.017
   Zhang XQ, 2019, CANCER NURS, V42, pE24, DOI 10.1097/NCC.0000000000000625
   Zhou YY, 2022, J INTERPERS VIOLENCE, V37, pNP1759, DOI 10.1177/0886260520933054
NR 50
TC 1
Z9 1
U1 1
U2 19
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1745-5057
EI 1745-5065
J9 WOMENS HEALTH
JI Womens Health
PY 2023
VL 19
AR 17455057231160955
DI 10.1177/17455057231160955
PG 12
WC Obstetrics & Gynecology
WE Emerging Sources Citation Index (ESCI)
SC Obstetrics & Gynecology
GA C2VO9
UT WOS:000960557600001
PM 36999312
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Riós, F
   Quintero, A
   Piloni, J
   Cariño, R
   Reyes, A
AF Rios, Fernanda
   Quintero, Aurora
   Piloni, Javier
   Carino, Raquel
   Reyes, Abigail
TI Bioactive compounds of cinnamon and their effect on decreasing metabolic
   syndrome: systematic review. Introduction. Metabolic syndrome (MS)
   increases. Introduction
SO ARCHIVOS LATINOAMERICANOS DE NUTRICION
LA English
DT Article
DE cinnamon; metabolic syndrome; bioactive compounds
ID BLOOD-PRESSURE; IN-VITRO; CHEMICAL-COMPOSITION; OXIDATIVE STRESS;
   EXTRACT; ZEYLANICUM; CINNAMALDEHYDE; METFORMIN; BARK; SUPPLEMENTATION
AB Metabolic syndrome (MS) increases hospital admission and the risk of developing COVID-19. Due to the side effects caused by the drugs used for its treatment, the search for therapeutic alternatives based on bioactive compounds contained in medicinal plants has been chosen. Cinnamon is used as a therapeutic agent due to its proven properties with various mechanisms of action reported in the treatment of various pathologies. Objective. To document the in vitro and in vivo studies, clinical studies and the mechanisms of action reported on the effect of the administration of cinnamon extracts and powder on comorbidities related to MS. Materials and methods. Systematic review of articles in electronic databases, including studies of cinnamon powder, aqueous extracts, ethyl acetate and methanol from cinnamon bark, over a period of 5 years, excluding all those articles related to its antimicrobial, antifungal and antimicrobial effect. cinnamon oil. Results. The evidence of the main bioactive compounds contained in cinnamon validates its potential in the treatment of diseases related to MS, with limited studies that investigate the mechanisms of action corresponding to its biological activities. Conclusions. Research evidence validates its potential in the treatment of these pathologies, due to its main bioactive compounds: cinnamaldehyde, transcinnamaldehyde, cinnamic acid, eugenol, and antioxidants of the proanthocyanidin A type and flavonoids, which participate in various mechanisms of action that activate and they inhibit enzymes, with hypoglycemic (kinase and phosphatase), antiobesogenic (UPC1), anti-inflammatory (NOS and COX), lipid-lowering (HMG-CoA) and antihypertensive (ACE) effects. Arch Latinoam Nutr 2023; 73(1): 74-85.
C1 [Rios, Fernanda; Quintero, Aurora; Piloni, Javier] Univ Autonoma Estado Hidalgo, Inst Ciencias Agr, Ave Univ Km,1 S-N Exhacienda Aquetzalpa, Tulancingo De Bravo 43600, Hidalgo, Mexico.
   [Carino, Raquel; Reyes, Abigail] Univ Autonoma Estado Hidalgo, Fac Ciencias Salud, Biol Reprod Ctr Invest, Dept Med,Lab Quim Med & Farmacol, Pachuca, Mexico.
   Univ Autonoma San Luis Potosi, Ciencias Quim, Ave Manuel Nava 6,Zona Univ, San Luis Potosi, Mexico.
C3 Universidad Autonoma del Estado de Hidalgo; Universidad Autonoma del
   Estado de Hidalgo; Universidad Autonoma de San Luis Potosi
RP Quintero, A (corresponding author), Univ Autonoma Estado Hidalgo, Inst Ciencias Agr, Ave Univ Km,1 S-N Exhacienda Aquetzalpa, Tulancingo De Bravo 43600, Hidalgo, Mexico.
EM aurora_quintero1489@uaeh.edu.mx
CR Abd Allah ESH, 2015, APPL PHYSIOL NUTR ME, V40, P1061, DOI 10.1139/apnm-2015-0145
   Abeysekera WPKM, 2017, EVID-BASED COMPL ALT, V2017
   Abeysekera WPKM, 2019, EVID-BASED COMPL ALT, V2019
   Abou-Khalil R, 2018, BIOCHIM CLIN, V42, P112, DOI 10.19186/BC_2018.023
   Alsoodeeri FN, 2020, J LIPIDS, V2020, DOI 10.1155/2020/8469830
   Anand V, 2016, SYST REV PHARM, V7, P24, DOI [10.5530/srp.2016.7.3, DOI 10.5530/SRP.2016.7.3]
   Anderson Richard A, 2016, J Tradit Complement Med, V6, P332
   [Anonymous], 2018, Encuesta Nacional de Salud y Nutricion
   Arisha SM, 2020, HELIYON, V6, DOI 10.1016/j.heliyon.2020.e05584
   Azimi P, 2016, BLOOD PRESSURE, V25, P133, DOI 10.3109/08037051.2015.1111020
   Balijepalli M K., 2017, International Journal of Pharmacy and Pharmaceutical Sciences, V9, P1, DOI [10.22159/ijpps.2017v9i2.11156, DOI 10.22159/IJPPS.2017V9I2.11156]
   Bastos MS, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0189619
   Beji RS, 2018, BRAZ J PHARM SCI, V54, DOI 10.1590/s2175-97902018000217576
   Bellosta S, 2018, EXPERT OPIN DRUG SAF, V17, P25, DOI 10.1080/14740338.2018.1394455
   Bi XY, 2017, FOOD CHEM, V217, P281, DOI 10.1016/j.foodchem.2016.08.111
   Borzoei Azam, 2018, J Tradit Complement Med, V8, P128, DOI 10.1016/j.jtcme.2017.04.008
   Cicero AFG, 2016, PHYTOMEDICINE, V23, P1134, DOI 10.1016/j.phymed.2015.11.009
   Crawford P, 2016, TRIALS, V17, DOI 10.1186/s13063-015-1138-7
   Davari M, 2020, NUTR J, V19, DOI 10.1186/s12937-019-0518-3
   Cenobio-Galindo AD, 2019, FOOD SCI BIOTECHNOL, V28, P1553, DOI 10.1007/s10068-019-00586-9
   Denova-Gutiérrez E, 2020, OBESITY, V28, P1826, DOI 10.1002/oby.22946
   Deyno S, 2019, DIABETES RES CLIN PR, P156
   du Souich P, 2017, PHARMACOL THERAPEUT, V175, P1, DOI 10.1016/j.pharmthera.2017.02.029
   Dujic T, 2016, DIABETIC MED, V33, P511, DOI 10.1111/dme.13040
   Engin A, 2017, ADV EXP MED BIOL, V960, P1, DOI 10.1007/978-3-319-48382-5_1
   Ge Q, 2017, J DIABETES RES, V2017, DOI 10.1155/2017/5837804
   Ghaffari S, 2019, BIOMED PHARMACOTHER, V109, P21, DOI 10.1016/j.biopha.2018.10.031
   Goldstein LB, 2017, JAMA-J AM MED ASSOC, V317, P1079, DOI 10.1001/jama.2017.0142
   Gunawardena D, 2015, FOOD FUNCT, V6, P910, DOI [10.1039/c4fo00680a, 10.1039/C4FO00680A]
   Hadi A, 2020, CLIN NUTR ESPEN, V36, P10, DOI 10.1016/j.clnesp.2020.01.002
   Hagenlocher Y, 2016, J NUTR BIOCHEM, V30, P85, DOI 10.1016/j.jnutbio.2015.11.015
   Haidari F, 2020, AVICENNA J PHYTOMEDI, V10, P243, DOI 10.22038/ajp.2019.13899
   Hammid SA, 2016, SAINS MALAYS, V45, P627
   Hendre A. S., 2019, Pravara Medical Review, V11, P4
   Hoi JK, 2020, ACS OMEGA, V5, P33305, DOI 10.1021/acsomega.0c05083
   Hosni AA, 2017, BIOMED PHARMACOTHER, V88, P52, DOI 10.1016/j.biopha.2017.01.054
   Hussain Z, 2019, BIOMED PHARMACOTHER, V109, P2285, DOI 10.1016/j.biopha.2018.11.123
   INEGI, 2020, Censo de Poblacion y Vivienda 2020, P1
   INEGI, 2020, CAR DEF REG MEX DUR
   Jahangir MA, 2017, ANN KING EDWARD MED, V23, P225
   Jain SG, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0504-8
   Karahalil B, 2017, ARH HIG RADA TOKSIKO, V68, P254, DOI 10.1515/aiht-2017-68-2994
   Kaskoos RA, 2019, J ESSENT OIL BEAR PL, V22, P535, DOI [10.1080/0972060x.2019.1612281, 10.1080/0972060X.2019.1612281]
   Kassaee SM, 2018, JUNDISHAPUR J NAT PH, V13, DOI 10.5812/jjnpp.38414
   Kassaee SM, 2017, JUNDISHAPUR J NAT PH, V12, DOI 10.5812/jjnpp.37340
   Kataria Vivek, 2017, J Pharm Pract, V30, P562, DOI 10.1177/0897190016652554
   Kaur Navrinder, 2019, Artif Cells Nanomed Biotechnol, V47, P2930, DOI 10.1080/21691401.2019.1641509
   Kim MS, 2019, FOOD FUNCT, V10, P4350, DOI 10.1039/c9fo00302a
   Kumar S, 2019, J PHARM PHARMACOL, V71, P1735, DOI 10.1111/jphp.13173
   Kwan HY, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-02263-5
   Lin GM, 2018, J SCI FOOD AGR, V98, P5908, DOI 10.1002/jsfa.9286
   Lin Gong-Min, 2016, J Tradit Complement Med, V6, P281, DOI 10.1016/j.jtcme.2015.08.005
   Liyanage T., 2017, Tropical Agricultural Research, V28, P270, DOI 10.4038/tar.v28i3.8231
   Lopes BP, 2015, FOOD FUNCT, V6, P3257, DOI [10.1039/c5fo00569h, 10.1039/C5FO00569H]
   Lopes BP, 2018, J FUNCT FOODS, V50, P210, DOI 10.1016/j.jff.2018.10.002
   Lopez de la Torre M., 2020, BMI Journal, V10, P2774
   Lu QY, 2017, J FOOD SCI, V82, P1807, DOI 10.1111/1750-3841.13792
   Maiti R, 2016, PAK J BOT, V48, P271
   Maruthamuthu R, 2016, Int. J. Pharmacogn. Phytochem. Res., V8, P1218
   Mazimba O., 2015, Journal of Medicinal Plants Studies, V3, P28
   McCrea CE, 2015, J TRANSL MED, V13, DOI 10.1186/s12967-014-0360-5
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Mirmiranpour H, 2020, J DIABETES METAB DIS, V19, P53, DOI 10.1007/s40200-019-00474-3
   Mohammed A, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00893
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Mousavi SM, 2020, CRIT REV FOOD SCI, V60, P3144, DOI 10.1080/10408398.2019.1678012
   Muhammad DRA, 2017, INT J FOOD PROP, V20, P2237, DOI 10.1080/10942912.2017.1369102
   Mukthamba P, 2015, FOOD FUNCT, V6, P3117, DOI [10.1039/C5FO00240K, 10.1039/c5fo00240k]
   Namazi N, 2019, COMPLEMENT THER MED, V43, P92, DOI 10.1016/j.ctim.2019.01.002
   Nayak IMN, 2017, J CLIN DIAGN RES, V11, DOI 10.7860/JCDR/2017/23910.9864
   Ndoen YEJ, 2016, J INT SCH C, V1, P150
   Nwaka C, 2019, IDOSR J SCI RES, V4, P91
   Pratibha, 2018, EUR J BIOMED PHARM S, V5, P964
   Puttaswamy NY, 2018, PAK J PHARM SCI, V31, P2367
   Qusti S, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/5614564
   Rajasekhar C., 2016, Journal of Chemical and Pharmaceutical Research, V8, P32
   Ranasinghe P, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-2067-7
   Ranjini HS, 2016, ASIAN J PHARM CLIN R, V9, P249, DOI DOI 10.22159/AJPCR.2016.V9I5.13424
   Romeo GR, 2020, J ENDOCR SOC, V4, DOI 10.1210/jendso/bvaa094
   Sahib AS, 2016, J INTERCULT ETHNOPHA, V5, P108, DOI 10.5455/jice.20160217044511
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sayad-Fathi S, 2020, EXCLI J, V19, P671, DOI 10.17179/excli2020-1960
   Schink A, 2018, FOOD FUNCT, V9, P5950, DOI [10.1039/C8FO01286E, 10.1039/c8fo01286e]
   Sedighi M, 2018, PHYTOTHER RES, V32, P1983, DOI 10.1002/ptr.6127
   Sengsuk C, 2016, DIABETOL INT, V7, P124, DOI 10.1007/s13340-015-0218-y
   Shahid M, 2020, ANN RES, V1, P24
   Sharafeldin K., 2015, Journal of Basic and Applied Zoology, V72, P126, DOI 10.1016/j.jobaz.2015.09.002
   Shawky E, 2018, PLANTA MED, V84, P1380, DOI 10.1055/a-0654-5468
   Shimna K., 2017, Journal of Plantation Crops, V45, P200
   Shirzad F, 2020, AVICENNA J PHYTOMEDI, V7, P1
   Sobczuk P, 2017, ONCOL LETT, V14, P5059, DOI 10.3892/ol.2017.6826
   Sohrabi M, 2018, IRAN J IMMUNOL, V15, P38, DOI IJIv15i1A4
   Song MY, 2017, AM J CHINESE MED, V45, P1017, DOI [10.1142/S0192415X17500549, 10.1142/s0192415x17500549]
   Suh S, 2015, ENDOCRINOL METAB, V30, P45, DOI 10.3803/EnM.2015.30.1.45
   Taheri A, 2018, XENOBIOTICA, V48, P984, DOI 10.1080/00498254.2017.1390626
   Talaei B, 2017, NUTRIENTS, V9, DOI 10.3390/nu9090991
   Tangvarasittichai S., 2015, IJTPR, V7, P158
   Tangvarasittichai S, 2015, WORLD J DIABETES, V7, P1
   Tilavat Y, 2017, J AYURVEDA INTEGR ME, V2, P69
   Tulini FL, 2016, FOOD RES INT, V85, P10, DOI 10.1016/j.foodres.2016.04.006
   Vakilwala M, 2017, INT J INNOV SCI RES, V4, P69
   Wright CB, 2015, J DIABETES RES, V564, P1
   Yun JW, 2018, REGUL TOXICOL PHARM, V95, P115, DOI 10.1016/j.yrtph.2018.02.017
   Zamani Zohreh, 2016, Adv Biomed Res, V5, P14, DOI 10.4103/2277-9175.175253
   Zare R, 2019, CLIN NUTR, V38, P549, DOI 10.1016/j.clnu.2018.03.003
   Zareie A, 2020, PHYTOTHER RES, V34, P2945, DOI 10.1002/ptr.6721
NR 106
TC 0
Z9 0
U1 1
U2 5
PU ARCHIVOS LATINOAMERICANOS NUTRICION
PI CARACAS
PA APARTADO 62778 CHACAO, AVENIDA FRANCISCO MIRANDA, CARACAS 1060,
   VENEZUELA
SN 0004-0622
EI 2309-5806
J9 ARCH LATINOAM NUTR
JI Arch. Latinoam. Nutr.
PD MAR
PY 2023
VL 73
IS 1
BP 74
EP 85
DI 10.37527/2023.73.1.007
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA F5CQ7
UT WOS:000982529800007
OA gold
DA 2025-06-11
ER

PT J
AU Mikolasevic, I
   Racki, S
   Lukenda, V
   Pavletic-Persic, M
   Milic, S
   Orlic, L
AF Mikolasevic, I.
   Racki, S.
   Lukenda, V.
   Pavletic-Persic, M.
   Milic, S.
   Orlic, L.
TI Non-alcoholic fatty liver disease; a part of the metabolic syndrome in
   the renal transplant recipient and possible cause of an allograft
   dysfunction
SO MEDICAL HYPOTHESES
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; KIDNEY-TRANSPLANTATION; DIABETES-MELLITUS; RISK;
   HYPERTENSION; PREVALENCE; MANAGEMENT; DIAGNOSIS
AB Despite all improvements in transplant medicine, renal transplant recipients have a high risk for cardiovascular mortality. A high prevalence of cardiovascular complications in renal transplant recipients (RTR) is explained by cardiovascular risk factors present before transplantation, in addition to the development of new risk factors as well as worsening of preexisting risk factors after transplantation. A majority ot these patients develop metabolic syndrome within a year after the transplantation. The metabolic syndrome (MS) is associated with impaired renal allograft function and increased insulin resistance. Non alcoholic fatty liver disease (NAFLD) represents a liver manifestation of metabolic syndrome and it development is strongly associated with all components of MS in general population. The current importance of NAFLD and its link to the MS has encouraged an interest in its possible role in the development of atherosclerosis in recent years. Considering the fact that all components of MS are more common among renal transplant recipients compared to general population, it would be expected that RTR may have a much higher incidence of NAFLD compared to general population. We propose that the presence of NAFLD in RTR could be a strong predictor in cardiovascular morbidity and mortality. Also, according to the recent investigations about the possible link between NAFLD and chronic kidney disease, we hypothesis that NAFLD may be associated with deteriorating graft function, causing a chronic allograft nephropathy and graft loss. Common factors underlying the pathogenesis of NAFLD and chronic allograft dysfunction may be insulin resistance, oxidative stress, activation of rennin-angiotensin system, and inappropriate secretion of inflammatory cytokines by steatotic and inflamed liver. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Mikolasevic, I.; Racki, S.; Pavletic-Persic, M.; Orlic, L.] Univ Hosp Ctr Rijeka, Div Internal Med, Dept Nephrol & Dialysis, Rijeka, Croatia.
   [Lukenda, V.] Dr Josip Bencevic Gen Hosp, Dept Internal Med, Slavonski Brod, Croatia.
   [Milic, S.] Univ Hosp Rijeka, Div Internal Med, Dept Gastroenterol, Rijeka, Croatia.
C3 University of Rijeka; University of Rijeka
RP Mikolasevic, I (corresponding author), Univ Hosp Ctr Rijeka, Div Internal Med, Dept Nephrol & Dialysis, Rijeka, Croatia.
EM ivana.mikolasevic@gmail.com
RI Sandra, Milic/S-5858-2018
OI Sandra, Milic/0000-0002-6635-5360
CR [Anonymous], METABOLISM
   Chalasani N, 2012, HEPATOLOGY, V55, P2005, DOI 10.1002/hep.25762
   Cheung C. Y., 2008, Hong Kong Medical Journal, V14, P379
   Dowman JK, 2011, ALIMENT PHARM THER, V33, P525, DOI 10.1111/j.1365-2036.2010.04556.x
   Elahi Tabassum, 2009, JPMA Journal of the Pakistan Medical Association, V59, P533
   Farrell GC, 2006, HEPATOLOGY, V43, pS99, DOI 10.1002/hep.20973
   Gore JL, 2006, AM J TRANSPLANT, V6, P357, DOI 10.1111/j.1600-6143.2005.01198.x
   Hamad Asma A, 2012, Arab J Gastroenterol, V13, P161, DOI 10.1016/j.ajg.2012.06.010
   Heisel O, 2004, AM J TRANSPLANT, V4, P583, DOI 10.1046/j.1600-6143.2003.00372.x
   Hjelmesæth J, 2001, NEPHROL DIAL TRANSPL, V16, P1047, DOI 10.1093/ndt/16.5.1047
   Hricik DE, 2011, CLIN J AM SOC NEPHRO, V6, P1781, DOI 10.2215/CJN.01200211
   Jardine AG, 2011, LANCET, V378, P1419, DOI 10.1016/S0140-6736(11)61334-2
   Kiberd B., 2007, ADV STUD MED, V7, P169
   Kim CH, 2008, CLEV CLIN J MED, V75, P721, DOI 10.3949/ccjm.75.10.721
   Lizardi-Cervera J, 2009, ANN HEPATOL, V8, pS40, DOI 10.1016/S1665-2681(19)31825-3
   Marcen Roberto, 2006, NEPHROLOGY DIALYSIS TRANSPLANTATION, V21, DOI [10.1093/ndt/gfl298, DOI 10.1093/NDT/GFL298]
   Midtvedt K, 2002, NEPHROL DIAL TRANSPL, V17, P1166, DOI 10.1093/ndt/17.7.1166
   Mikolasevic Ivana, 2012, Acta Medica Croatica, V66, P235
   Oruc M, 2013, TRANSPL P, V45, P3273, DOI 10.1016/j.transproceed.2013.06.005
   Ponticelli C, 2011, TRANSPL INT, V24, P523, DOI 10.1111/j.1432-2277.2011.01242.x
   Rajman I, 1998, NEPHROL DIAL TRANSPL, V13, P2281, DOI 10.1093/ndt/13.9.2281
   Ravindran V, 2004, YONSEI MED J, V45, P1059, DOI 10.3349/ymj.2004.45.6.1059
   Soveri I, 2012, J NEPHROL, V25, P245, DOI 10.5301/JN.2011.8450
   Targher G, 2008, DIABETOLOGIA, V51, P1947, DOI 10.1007/s00125-008-1135-4
   Targher G, 2010, CLIN J AM SOC NEPHRO, V5, P2166, DOI 10.2215/CJN.05050610
   Targher G, 2011, J HEPATOL, V54, P1020, DOI 10.1016/j.jhep.2010.11.007
   Yasui K, 2011, METABOLISM, V60, P735, DOI 10.1016/j.metabol.2010.07.022
NR 27
TC 16
Z9 16
U1 0
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD JAN
PY 2014
VL 82
IS 1
BP 36
EP 39
DI 10.1016/j.mehy.2013.10.030
PG 4
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 295WZ
UT WOS:000330148400008
PM 24280560
DA 2025-06-11
ER

PT J
AU Marchesini, G
   Marzocchi, R
   Agostini, F
   Bugianesi, E
AF Marchesini, G
   Marzocchi, R
   Agostini, F
   Bugianesi, E
TI Nonalcoholic fatty liver disease and the metabolic syndrome
SO CURRENT OPINION IN LIPIDOLOGY
LA English
DT Review
DE diabetes; dyslipidemia; hypertension; steatohepatitis; treatment
ID INSULIN-RESISTANCE; HEPATIC STEATOSIS; VITAMIN-E; STEATOHEPATITIS;
   METFORMIN; PENTOXIFYLLINE; ADIPONECTIN; PREVALENCE; PATHOGENESIS;
   FIBROSIS
AB Purpose of review Clinical, epidemiological and biochemical data strongly support the concept that nonalcoholic fatty liver disease is the hepatic manifestation of the metabolic syndrome. Insulin resistance is the common factor connecting obesity, diabetes, hypertension and dyslipidemia with fatty liver and the progression of hepatic disease to steatohepatitis, fibrosis, cirrhosis and hepatocellular carcinoma.
   Recent findings The association of nonalcoholic fatty liver disease with the features of the metabolic syndrome has been confirmed in several epidemiological studies. The diagnostic and clinical significance of raised liver enzymes has been questioned; advanced hepatic disease may also be present in individuals with ultrasonographically detected steatosis and normal aminotransferase levels. The role of adipokines (leptin, adiponectin) and cytokines (tumor necrosis factor-a, interleukin-6, transforming growth factor-P) in disease progression is probably pivotal, mediated by oxidative stress. The importance of iron accumulation in this process has not been confirmed. Treatments aimed at weight loss remain a primary option; among pharmacological interventions, insulin sensitizers (glitazones and metformin) have confirmed beneficial effects on both biochemical and histological data, but new treatments are on the horizon.
   Summary Nonalcoholic fatty liver disease prevalence in Western countries is high and there is a trend towards a further increase, with millions of people at risk of advanced liver disease. The epidemiological evidence, the lifestyle origin of the disease and the cost of pharmacotherapy make prevention a primary goal, and will contribute to making behavior therapy the background treatment. We need specific programs and carefully controlled, randomized studies to tackle simultaneously all the components of the metabolic syndrome.
C1 Alma Mater Studiorum Univ Bologna, Unit Metab Dis, Policlin S Orsola, I-40138 Bologna, Italy.
   Univ Turin, Dept Gastroenterol, I-10124 Turin, Italy.
C3 IRCCS Azienda Ospedaliero-Universitaria di Bologna; University of
   Bologna; University of Turin
RP Alma Mater Studiorum Univ Bologna, Unit Metab Dis, Policlin S Orsola, Via Massarenti 9, I-40138 Bologna, Italy.
EM giulio.marchesini@unibo.it
RI Agostini, Francesco/AFK-7503-2022
OI Marchesini, Giulio/0000-0003-2407-9860; agostini,
   federica/0000-0002-6577-458X
CR Abrams GA, 2004, HEPATOLOGY, V40, P475, DOI 10.1002/hep.20323
   Adams LA, 2005, J HEPATOL, V42, P132, DOI 10.1016/j.jhep.2004.09.012
   Adams LA, 2004, AM J GASTROENTEROL, V99, P2365, DOI 10.1111/j.1572-0241.2004.40064.x
   Adams LA, 2004, CLIN GASTROENTEROL H, V2, P1059, DOI 10.1016/S1542-3565(04)00462-8
   Akriviadis E, 2000, GASTROENTEROLOGY, V119, P1637, DOI 10.1053/gast.2000.20189
   Anderson PJ, 2001, INT J OBESITY, V25, P1782, DOI 10.1038/sj.ijo.0801837
   Angelico F, 2005, J CLIN ENDOCR METAB, V90, P1578, DOI 10.1210/jc.2004-1024
   BREA A, 2005, ARTERIOSCLER THROMB, V25
   Browning JD, 2004, AM J GASTROENTEROL, V99, P292, DOI 10.1111/j.1572-0241.2004.04059.x
   Browning JD, 2004, HEPATOLOGY, V40, P1387, DOI 10.1002/hep.20466
   Browning JD, 2004, J CLIN INVEST, V114, P147, DOI 10.1172/JCI200422422
   Brunt EM, 2004, HUM PATHOL, V35, P1070, DOI 10.1016/j.humpath.2004.04.017
   Bugianesi E, 2004, BEST PRACT RES CL GA, V18, P1105, DOI [10.1016/j.bpg.2004.06.025, 10.1016/S1521-6918(04)00086-1]
   Bugianesi E, 2004, HEPATOLOGY, V39, P179, DOI 10.1002/hep.20023
   Bugianesi E, 2005, AM J GASTROENTEROL, V100, P1082, DOI 10.1111/j.1572-0241.2005.41583.x
   Caldwell SH, 2002, AM J GASTROENTEROL, V97, P1496, DOI 10.1016/S0002-9270(02)04151-5
   Chalasani N, 2004, AM J GASTROENTEROL, V99, P1497, DOI 10.1111/j.1572-0241.2004.30159.x
   Chitturi S, 2004, J GASTROEN HEPATOL, V19, P368, DOI 10.1111/j.1440-1746.2003.03252.x
   den Boer M, 2004, ARTERIOSCL THROM VAS, V24, P644, DOI 10.1161/01.ATV.0000116217.57583.6e
   Diehl AM, 2005, GUT, V54, P303, DOI 10.1136/gut.2003.024935
   Dixon JB, 2004, HEPATOLOGY, V39, P1647, DOI 10.1002/hep.20251
   Donati G, 2004, GUT, V53, P1020, DOI 10.1136/gut.2003.027086
   Fassio E, 2004, HEPATOLOGY, V40, P820, DOI 10.1002/hep.20410
   Harrison Stephen A, 2004, Clin Liver Dis, V8, P715, DOI 10.1016/j.cld.2004.04.011
   Hickman IJ, 2004, GUT, V53, P413, DOI 10.1136/gut.2003.027581
   Hui JM, 2004, HEPATOLOGY, V40, P46, DOI 10.1002/hep.20280
   Javor ED, 2005, HEPATOLOGY, V41, P753, DOI 10.1002/hep.20672
   López-Bermejo A, 2004, CLIN ENDOCRINOL, V60, P256, DOI 10.1046/j.1365-2265.2004.01977.x
   Marchesini G, 2003, HEPATOLOGY, V37, P917, DOI 10.1053/jhep.2003.50161
   Marchesini G, 2001, LANCET, V358, P893, DOI 10.1016/S0140-6736(01)06042-1
   Matsubara M, 2004, ENDOCR J, V51, P587, DOI 10.1507/endocrj.51.587
   Medina J, 2004, DIABETES CARE, V27, P2057, DOI 10.2337/diacare.27.8.2057
   Meigs JB, 2000, AM J EPIDEMIOL, V152, P908, DOI 10.1093/aje/152.10.908
   Nair S, 2004, ALIMENT PHARM THERAP, V20, P23, DOI 10.1111/j.1365-2036.2004.02025.x
   NEUNER P, 1994, IMMUNOLOGY, V83, P262
   Neuschwander-Tetri BA, 2003, HEPATOLOGY, V38, P1008, DOI 10.1053/jhep.2003.50420
   Promrat K, 2004, HEPATOLOGY, V39, P188, DOI 10.1002/hep.20012
   Sanyal AJ, 2004, CLIN GASTROENTEROL H, V2, P1107, DOI 10.1016/S1542-3565(04)00457-4
   Sorrentino P, 2004, J HEPATOL, V41, P751, DOI 10.1016/j.jhep.2004.07.010
   Targher G, 2004, CLIN ENDOCRINOL, V61, P700, DOI 10.1111/j.1365-2265.2004.02151.x
   Unger RH, 2002, ANNU REV MED, V53, P319, DOI 10.1146/annurev.med.53.082901.104057
   Uygun A, 2004, ALIMENT PHARM THER, V19, P537, DOI 10.1111/j.1365-2036.2004.01888.x
   Weston SR, 2005, HEPATOLOGY, V41, P372, DOI 10.1002/hep.20554
   WHO, 2004, LANCET, V363, P902, DOI 10.1016/S0140-6736(03)15268-3
   Yokohama S, 2004, HEPATOLOGY, V40, P1222, DOI 10.1002/hep.20420
NR 45
TC 264
Z9 308
U1 0
U2 22
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0957-9672
EI 1473-6535
J9 CURR OPIN LIPIDOL
JI Curr. Opin. Lipidology
PD AUG
PY 2005
VL 16
IS 4
BP 421
EP 427
DI 10.1097/01.mol.0000174153.53683.f2
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Peripheral
   Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Cardiovascular System & Cardiology
GA 948FN
UT WOS:000230701500006
PM 15990591
DA 2025-06-11
ER

PT J
AU Scorza, FA
   de Albuquerque, M
   Arida, RM
   Cysneiros, RM
AF Scorza, Fulvio A.
   de Albuquerque, Marly
   Arida, Ricardo M.
   Cysneiros, Roberta Monterazzo
TI Serum levels of magnesium in sudden cardiac deaths among people with
   schizophrenia: hit or miss?
SO ARQUIVOS DE NEURO-PSIQUIATRIA
LA English
DT Article
DE schizophrenia; sudden death; magnesium
ID CARDIOVASCULAR-DISEASE; ATHEROSCLEROSIS RISK; ANTIPSYCHOTIC-DRUGS;
   METABOLIC SYNDROME; CALCIUM
AB Schizophrenia is a devastating mental disorder, affecting cognitive, emotional, and behavioral conditions, ability to work, social functioning, family stability and self-esteem of the patient. People with schizophrenia show a two to three-fold increased risk to die prematurely than those without schizophrenia. Understanding the mechanisms behind sudden cardiac death in individuals with schizophrenia is a key to prevention. Although different mechanisms may be related, there are clear indications that cardiac abnormalities play a potential role. Some antipsychotics may be associated with cardiovascular adverse events, e. g., QT interval prolongation, metabolic dysfunction, blood pressure and heart rate alterations. Magnesium (Mg) abnormalities may lead to various morphological and functional dysfunctions of the heart and low levels of serum Mg are considered to be at high risk for sudden cardiac death. As low serum Mg is associated with detrimental effects on the heart and that antipsychotic-treated schizophrenia patients frequently affect the heart rate, possibly, these factors together must change the normal functioning of the heart and consequently being able to culminate in a catastrophic event.
C1 [Scorza, Fulvio A.; de Albuquerque, Marly] UNIFESP EPM, Disciplina Neurol Expt, BR-04023900 Sao Paulo, Brazil.
   [Arida, Ricardo M.] UNIFESP EPM, Dept Fisiol, BR-04023900 Sao Paulo, Brazil.
   [Cysneiros, Roberta Monterazzo] Univ Presbiteriana Mackenzie, Programa Posgrad Disturbios Desenvolvimento, Sao Paulo, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Sao
   Paulo (UNIFESP); Universidade Presbiteriana Mackenzie
RP Scorza, FA (corresponding author), UNIFESP EPM, Disciplina Neurol Expt, Rua Botucatu 862,Edificio Leal Prado, BR-04023900 Sao Paulo, Brazil.
EM scorza.nexp@epm.br
RI Scorza, Francesco/J-5932-2019; Arida, RIcardo Mario/P-7408-2016; Scorza,
   Fulvio/C-7048-2013; Arida, Ricardo/E-2667-2013
OI Monterazzo Cysneiros, Roberta/0000-0002-3191-9146; Arida, RIcardo
   Mario/0000-0002-7771-6133; Scorza, Fulvio/0000-0002-0694-8674; Arida,
   Ricardo/0000-0002-0908-3274
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP); Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq); Instituto
   Nacional de Neurociencia Translacional; Fundacao de Amparo a Pesquisa do
   Estado de Minas Gerais (FAPEMIG)
FX Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Instituto
   Nacional de Neurociencia Translacional, Fundacao de Amparo a Pesquisa do
   Estado de Minas Gerais (FAPEMIG).
CR ALEXANDER PE, 1978, BRIT J PSYCHIAT, V133, P143, DOI 10.1192/bjp.133.2.143
   ALEXANDER PE, 1979, ARCH GEN PSYCHIAT, V36, P1372, DOI 10.1001/archpsyc.1979.01780120102012
   [Anonymous], 2003, CLOZ CLOZ PACK INS
   [Anonymous], 1998, J CLIN PSYCHIAT S12, V59, P17
   ATHANASSENAS G, 1983, J CLIN PSYCHOPHARM, V3, P212
   Auquier P, 2006, PHARMACOEPIDEM DR S, V15, P873, DOI 10.1002/pds.1325
   Bobes J, 2007, SCHIZOPHR RES, V90, P162, DOI 10.1016/j.schres.2006.09.025
   Chakraborti S, 2002, MOL CELL BIOCHEM, V238, P163, DOI 10.1023/A:1019998702946
   Glassman AH, 2005, J CLIN PSYCHIAT, V66, P5
   Koponen H, 2008, NORD J PSYCHIAT, V62, P342, DOI 10.1080/08039480801959323
   Levine J, 1996, NEUROPSYCHOBIOLOGY, V33, P169, DOI 10.1159/000119272
   Liao FZ, 1998, AM HEART J, V136, P480, DOI 10.1016/S0002-8703(98)70224-8
   National Institute of Mental Health, 2006, NUMB COUNT MENT DIS
   Peacock JM, 2010, AM HEART J, V160, P464, DOI 10.1016/j.ahj.2010.06.012
   Regitz-Zagrosek V, 2006, CLIN RES CARDIOL, V95, P136, DOI 10.1007/s00392-006-0351-5
   Ruschena D, 1998, BRIT J PSYCHIAT, V172, P331, DOI 10.1192/bjp.172.4.331
   Ryan MCM, 2002, LIFE SCI, V71, P239, DOI 10.1016/S0024-3205(02)01646-6
   Scorza FA, 2012, EPILEPSY RES, V101, P293, DOI 10.1016/j.eplepsyres.2012.04.010
   Scorza FA, 2006, REV BRAS PSIQUIATR, V28, P339, DOI 10.1590/S1516-44462006000400016
   Straus SMJM, 2004, ARCH INTERN MED, V164, P1293, DOI 10.1001/archinte.164.12.1293
   Straus SMJM, 2004, J CLIN EPIDEMIOL, V57, P98, DOI 10.1016/S0895-4356(03)00210-5
   Terra VC, 2011, J EPILEPSY CLIN NEUR, V17, P75
   Zarate CA, 2001, ARCH GEN PSYCHIAT, V58, P1168, DOI 10.1001/archpsyc.58.12.1168
   Zipes DP, 1998, CIRCULATION, V98, P2334, DOI 10.1161/01.CIR.98.21.2334
NR 24
TC 3
Z9 4
U1 0
U2 4
PU ASSOC ARQUIVOS NEURO- PSIQUIATRIA
PI SAO PAULO SP
PA PR AMADEU AMARAL 47/33, 01327-010 SAO PAULO SP, BRAZIL
SN 0004-282X
J9 ARQ NEURO-PSIQUIAT
JI Arq. Neuro-Psiquiatr.
PD OCT
PY 2012
VL 70
IS 10
BP 814
EP 816
DI 10.1590/S0004-282X2012001000011
PG 3
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 019EJ
UT WOS:000309719600011
PM 23060109
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU DeVallance, E
   Branyan, KW
   Lemaster, K
   Olfert, IM
   Smith, DM
   Pistilli, EE
   Frisbee, JC
   Chantler, PD
AF DeVallance, Evan
   Branyan, Kayla W.
   Lemaster, Kent
   Olfert, I. Mark
   Smith, David M.
   Pistilli, Emidio E.
   Frisbee, Jefferson C.
   Chantler, Paul D.
TI Aortic dysfunction in metabolic syndrome mediated by perivascular
   adipose tissue TNF- and NOX2-dependent pathway
SO EXPERIMENTAL PHYSIOLOGY
LA English
DT Article
DE metabolic syndrome; perivascular adipose tissue; tumour necrosis factor-
   alpha
ID MICROVASCULAR ENDOTHELIAL-CELLS; ENDOPLASMIC-RETICULUM STRESS;
   NITRIC-OXIDE SYNTHASE; PULSE-WAVE VELOCITY; OBESE ZUCKER RATS; NADPH
   OXIDASE; MATRIX METALLOPROTEINASES; ARTERIAL STIFFNESS; INFLAMMATORY
   RESPONSE; VASCULAR DYSFUNCTION
AB Perivascular adipose tissue (PVAT) is recognized for its vasoactive effects, but it is unclear how metabolic syndrome impacts thoracic aorta (t)PVAT and the subsequent effect on functional and structural aortic stiffness. Thoracic aorta and tPVAT were removed from 16- to 17-week-old lean (LZR, n=16) and obese Zucker rats (OZR, n=16). The OZR presented with aortic endothelial dysfunction, assessed by wire myography, and increased aortic stiffness, assessed by elastic modulus. The OZR tPVAT exudate further exacerbated the endothelial dysfunction, reducing nitric oxide and endothelium-dependent relaxation (P<0.05). Additionally, OZR tPVAT exudate had increased MMP9 activity (P<0.05) and further increased the elastic modulus of the aorta after 72h of co-culture (P<0.05). We found that the observed aortic dysfunction caused by OZR tPVAT was mediated through increased production and release of tumour necrosis factor- (TNF; P<0.01), which was dependent on tPVAT NADPH-oxidase 2 (NOX2) activity. The OZR tPVAT release of reactive oxygen species and subsequent aortic dysfunction were inhibited by TNF neutralization and/or inhibition of NOX2. Additionally, we found that OZR tPVAT had reduced activity of the active sites of the 20S proteasome (P<0.05) and reduced superoxide dismutase activity (P<0.01). In conclusion, metabolic syndrome causes tPVAT dysfunction through an interplay between TNF and NOX2 that leads to tPVAT-mediated aortic stiffness by activation of aortic reactive oxygen species and increased MMP9 activity.
C1 [DeVallance, Evan; Branyan, Kayla W.; Olfert, I. Mark; Pistilli, Emidio E.; Chantler, Paul D.] West Virginia Univ, Div Exercise Physiol, Sch Med, Morgantown, WV USA.
   [Lemaster, Kent; Frisbee, Jefferson C.] Univ Western Ontario, Schulich Sch Med & Dent, Dept Physiol & Pharmacol, London, ON, Canada.
   [Smith, David M.] West Virginia Univ, Dept Biochem, Sch Med, Morgantown, WV USA.
   [Frisbee, Jefferson C.] Univ Western Ontario, Schulich Sch Med & Dent, Dept Med Biophys, London, ON, Canada.
C3 West Virginia University; Western University (University of Western
   Ontario); West Virginia University; Western University (University of
   Western Ontario)
RP Chantler, PD (corresponding author), One Med Ctr Dr, Morgantown, WV 26505 USA.
EM pchantler@hsc.wvu.edu
RI Smith, David/AAL-7662-2020
OI Chantler, Paul/0000-0001-6960-9728; Branyan, Kayla/0000-0003-1038-8080;
   Smith, David/0000-0002-1502-676X; Frisbee, Jefferson/0000-0003-2751-0599
FU American Heart Association [IRG14330015]; AHA [14PRE20380386,
   16PRE30820000]; National Institute of General Medical Sciences of the
   National Institutes of Health [U54GM104942, 5P20GM109098]; American
   Heart Association (AHA) [16PRE30820000, 14PRE20380386] Funding Source:
   American Heart Association (AHA)
FX This study was supported by the American Heart Association grants
   IRG14330015, pre-doctoral fellowship AHA (14PRE20380386, 16PRE30820000);
   and National Institute of General Medical Sciences of the National
   Institutes of Health (U54GM104942 and 5P20GM109098).
CR Bedard K, 2007, PHYSIOL REV, V87, P245, DOI 10.1152/physrev.00044.2005
   Bouloumié A, 2001, DIABETES, V50, P2080, DOI 10.2337/diabetes.50.9.2080
   Brooks SD, 2015, AM J PHYSIOL-HEART C, V309, pH1846, DOI 10.1152/ajpheart.00691.2015
   Brown RD, 2007, BIOCHEM BIOPH RES CO, V362, P200, DOI 10.1016/j.bbrc.2007.08.003
   Chakraborti S, 2003, MOL CELL BIOCHEM, V253, P269, DOI 10.1023/A:1026028303196
   Chen JY, 2013, ARTERIOSCL THROM VAS, V33, P839, DOI 10.1161/ATVBAHA.112.300036
   Chen XL, 2004, AM J PHYSIOL-HEART C, V286, pH1001, DOI 10.1152/ajpheart.00716.2003
   Díaz-Ruiz A, 2015, ANTIOXID REDOX SIGN, V23, P597, DOI 10.1089/ars.2014.5939
   Didion SP, 2009, HYPERTENSION, V54, P619, DOI 10.1161/HYPERTENSIONAHA.109.137158
   Donley DA, 2014, J APPL PHYSIOL, V116, P1396, DOI 10.1152/japplphysiol.00151.2014
   Donnini S, 2004, LIFE SCI, V74, P2975, DOI 10.1016/j.lfs.2003.09.075
   Fairaq A, 2015, MOL CELL BIOCHEM, V406, P227, DOI 10.1007/s11010-015-2440-0
   Fitch RM, 2001, CARDIOVASC RES, V51, P351, DOI 10.1016/S0008-6363(01)00299-1
   Fleenor BS, 2014, AGING CELL, V13, P576, DOI 10.1111/acel.12196
   Gao YJ, 2007, BRIT J PHARMACOL, V151, P323, DOI 10.1038/sj.bjp.0707228
   GEARING AJH, 1994, NATURE, V370, P555, DOI 10.1038/370555a0
   Ghosh AK, 2015, J GERONTOL A-BIOL, V70, P1320, DOI 10.1093/gerona/glu186
   Greenstein AS, 2009, CIRCULATION, V119, P1661, DOI 10.1161/CIRCULATIONAHA.108.821181
   Gurjar MV, 1999, ARTERIOSCL THROM VAS, V19, P2871, DOI 10.1161/01.ATV.19.12.2871
   Gurjar MV, 2001, AM J PHYSIOL-HEART C, V281, pH2568, DOI 10.1152/ajpheart.2001.281.6.H2568
   Höhn A, 2016, ANTIOXID REDOX SIGN, V25, P902, DOI 10.1089/ars.2016.6815
   Isenberg JS, 2009, NAT REV CANCER, V9, P182, DOI 10.1038/nrc2561
   Jenkins GM, 1998, CIRCULATION, V97, P82, DOI 10.1161/01.CIR.97.1.82
   Katakam PVG, 2006, AM J PHYSIOL-REG I, V290, pR145, DOI 10.1152/ajpregu.00405.2005
   Kim YS, 2007, MOL CELL, V26, P675, DOI 10.1016/j.molcel.2007.04.021
   Lakatta EG, 2003, CIRCULATION, V107, P139, DOI 10.1161/01.CIR.0000048892.83521.58
   Laursen JB, 2001, CIRCULATION, V103, P1282
   Levy BI, 2001, CIRCULATION, V104, P735, DOI 10.1161/hc3101.091158
   Li JM, 2005, MOL CELL BIOL, V25, P2320, DOI 10.1128/MCB.25.6.2320-2330.2005
   Lin Y, 2005, J BIOL CHEM, V280, P4617, DOI 10.1074/jbc.M411863200
   Mandler WK, 2017, NANOTOXICOLOGY, V11, P112, DOI 10.1080/17435390.2016.1277275
   Mikolajczyk TP, 2016, FASEB J, V30, P1987, DOI 10.1096/fj.201500088R
   Mingorance C, 2009, OBESITY, V17, P1340, DOI 10.1038/oby.2009.20
   OROURKE M, 1990, HYPERTENSION, V15, P339, DOI 10.1161/01.HYP.15.4.339
   Otoda T, 2013, DIABETES, V62, P811, DOI 10.2337/db11-1652
   Parameswaran N, 2010, CRIT REV EUKAR GENE, V20, P87, DOI 10.1615/CritRevEukarGeneExpr.v20.i2.10
   Raychaudhuri B, 2000, CYTOKINE, V12, P1348, DOI 10.1006/cyto.2000.0721
   Roderfeld M, 2007, BIOL CHEM, V388, P1227, DOI 10.1515/BC.2007.123
   Saji N, 2012, INTERNAL MED, V51, P1003, DOI 10.2169/internalmedicine.51.6852
   Sakamoto T, 2013, AM J PHYSIOL-CELL PH, V304, pC729, DOI 10.1152/ajpcell.00312.2012
   Saperstein S, 2009, J INTERF CYTOK RES, V29, P273, DOI 10.1089/jir.2008.0076
   Schönbeck U, 1998, J IMMUNOL, V161, P3340
   Sen CK, 1996, FASEB J, V10, P709, DOI 10.1096/fasebj.10.7.8635688
   Serpillon S, 2009, AM J PHYSIOL-HEART C, V297, pH153, DOI 10.1152/ajpheart.01142.2008
   Shimizu I, 2014, J CLIN INVEST, V124, P2099, DOI 10.1172/JCI71643
   Smith DM, 2011, CELL, V144, P526, DOI 10.1016/j.cell.2011.02.005
   Turner NA, 2007, CARDIOVASC RES, V76, P81, DOI 10.1016/j.cardiores.2007.06.003
   Vásquez-Vivar J, 1998, P NATL ACAD SCI USA, V95, P9220, DOI 10.1073/pnas.95.16.9220
   Virdis A, 2015, EUR HEART J, V36, P784, DOI 10.1093/eurheartj/ehu072
   Wang YJ, 2014, CIRC RES, V114, P792, DOI 10.1161/CIRCRESAHA.114.302439
   Wang ZV, 2008, HYPERTENSION, V51, P8, DOI 10.1161/HYPERTENSIONAHA.107.099424
   Wilkinson IB, 2004, HYPERTENSION, V44, P112, DOI 10.1161/01.HYP.0000138068.03893.40
   Wu HT, 2013, APPL BIOCHEM BIOTECH, V169, P438, DOI 10.1007/s12010-012-9958-3
   Yang BH, 2007, AM J PHYSIOL-HEART C, V292, pH954, DOI 10.1152/ajpheart.00758.2006
   Yasmin, 2005, ARTERIOSCL THROM VAS, V25, P372, DOI 10.1161/01.ATV.0000151373.33830.41
   Zemse SM, 2010, AM J PHYSIOL-HEART C, V299, pH1160, DOI 10.1152/ajpheart.00763.2009
   Zhang M, 2006, CIRCULATION, V113, P1235, DOI 10.1161/CIRCULATIONAHA.105.581397
NR 57
TC 30
Z9 31
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0958-0670
EI 1469-445X
J9 EXP PHYSIOL
JI Exp. Physiol.
PD APR 1
PY 2018
VL 103
IS 4
BP 590
EP 603
DI 10.1113/EP086818
PG 14
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA GB1YV
UT WOS:000428848500019
PM 29349831
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Medeiros, RF
   Gaique, TG
   Bento-Bernardes, T
   Kindlovits, R
   Gomes, TMB
   Motta, NAV
   Brito, FC
   Fernandes-Santos, C
   Oliveira, KJ
   Nóbrega, ACL
AF Medeiros, Renata F.
   Gaique, Thaiane G.
   Bento-Bernardes, Thais
   Kindlovits, Raquel
   Gomes, Tamiris M. B.
   Motta, Nadia Alice V.
   Brito, Fernanda Carla
   Fernandes-Santos, Caroline
   Oliveira, Karen J.
   Nobrega, Antonio Claudio L.
TI Arginine and aerobic training prevent endothelial and metabolic
   alterations in rats at high risk for the development of the metabolic
   syndrome
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Metabolic syndrome; Fructose; Aerobic training; Arginine supplementation
ID TYPE-2 DIABETES-MELLITUS; HEART-FAILURE RATS; FRUCTOSE FED RATS;
   INSULIN-RESISTANCE; PHYSICAL-ACTIVITY; NITRIC-OXIDE;
   CARDIOVASCULAR-DISEASE; DIETARY FRUCTOSE; OXIDATIVE STRESS;
   HYPERCHOLESTEROLEMIC RABBIT
AB Endothelial function is a key mechanism in the development of CVD. Arginine and exercise are important non-pharmacological strategies for mitigating the impact of metabolic changes in the metabolic syndrome, but the effect of their combined administration is unknown. Thus, the aim of this study was to investigate the isolated and combined effects of aerobic training and arginine supplementation on metabolic variables and vascular reactivity in rats at high risk for developing the metabolic syndrome. Wistar rats were divided into two groups: control and fructose (F-water with 10% fructose). After 2 weeks, the F group was divided into four groups: F, fructose + arginine (FA, 880 mg/kg per d of L-arginine), fructose + training (FT) and fructose + arginine + training (FTA); treatments lasted for 8 weeks, and no difference was observed in body mass gain. Arginine did not improve the body protein content, and both the FA and FT groups show a reversal of the increase in adipose tissue. Insulin increase was prevented by training and arginine, without additive effect, and the increase in serum TAG was prevented only by training. The F group showed impaired endothelium-dependent vasodilation and hyperreactivity to phenylephrine, but arginine and training were capable of preventing these effects, even separately. Higher nitric oxide level was observed in the FA and FT groups, and no potentiating effect was detected. Thus, only training was able to prevent the increase in TAG and improve the protein mass, and training and arginine exert similar effects on fat content, insulin and endothelial function, but these effects are not additive.
C1 [Medeiros, Renata F.; Gaique, Thaiane G.; Bento-Bernardes, Thais; Kindlovits, Raquel; Gomes, Tamiris M. B.; Motta, Nadia Alice V.; Brito, Fernanda Carla; Oliveira, Karen J.; Nobrega, Antonio Claudio L.] Fluminense Fed Univ, Dept Physiol & Pharmacol, BR-24210130 Niteroi, RJ, Brazil.
   [Fernandes-Santos, Caroline] Fluminense Fed Univ, Dept Basic Sci, BR-28625650 Nova Friburgo, RJ, Brazil.
C3 Universidade Federal Fluminense; Universidade Federal Fluminense
RP Medeiros, RF (corresponding author), Fluminense Fed Univ, Dept Physiol & Pharmacol, BR-24210130 Niteroi, RJ, Brazil.
EM frauches.renata@gmail.com
RI brito, fernanda/AAL-8474-2021; Oliveira, Karen/AAV-6843-2020;
   Bento-Bernardes, Thais/AAZ-4284-2021; Medeiros, Renata/AAP-3429-2021;
   Fernandes-Santos, Caroline/M-1794-2019
OI Kindlovits, Raquel/0000-0003-2720-0603; Oliveira,
   Karen/0000-0003-2320-8683; Fernandes-Santos,
   Caroline/0000-0002-2420-3836
FU CAPES (Coordination for the Improvement of Higher Education Personnel)
   [473816/2014-8]; FAPERJ (State of Rio de Janeiro Agency for Research
   Support) [110.310/2014]; CNPq (National Council of Scientific and
   Technological Development) [487.584/2013-9]
FX This work was supported by CAPES (Coordination for the Improvement of
   Higher Education Personnel; grant no. 473816/2014-8), FAPERJ (State of
   Rio de Janeiro Agency for Research Support; grant no. 110.310/2014) and
   CNPq (National Council of Scientific and Technological Development;
   grant no. 487.584/2013-9).
CR Alvares TS, 2014, NUTR RES, V34, P31, DOI 10.1016/j.nutres.2013.10.006
   Ando K, 2009, FREE RADICAL BIO MED, V47, P213, DOI 10.1016/j.freeradbiomed.2009.04.030
   Andrew PJ, 1999, CARDIOVASC RES, V43, P521, DOI 10.1016/S0008-6363(99)00115-7
   [Anonymous], 2011, Cent Eur J Public Health, V19, P138
   [Anonymous], 2011, Scaling up action against NCDs: how much will it cost?
   Bai YY, 2009, AM J CLIN NUTR, V89, P77, DOI 10.3945/ajcn.2008.26544
   BANTLE JP, 1992, DIABETES CARE, V15, P1468, DOI 10.2337/diacare.15.11.1468
   Basciano Heather, 2005, Nutr Metab (Lond), V2, P5, DOI 10.1186/1743-7075-2-5
   BEERE PA, 1992, ARTERIOSCLER THROMB, V12, P1245, DOI 10.1161/01.ATV.12.11.1245
   Bode-Böger SM, 2003, VASC MED, V8, P77, DOI 10.1191/1358863x03vm474oa
   Bode-Böger SM, 1998, BRIT J CLIN PHARMACO, V46, P489, DOI 10.1046/j.1365-2125.1998.00803.x
   Bogdanski P, 2012, EUR REV MED PHARMACO, V16, P816
   Cai H, 2000, CIRC RES, V87, P840, DOI 10.1161/01.RES.87.10.840
   Carvalho DS, 2016, EUR J PHARMACOL, V791, P780, DOI 10.1016/j.ejphar.2016.10.001
   Chou CL, 2013, HYPERTENS RES, V36, P123, DOI 10.1038/hr.2012.124
   Chromiak JA, 2002, NUTRITION, V18, P657, DOI 10.1016/S0899-9007(02)00807-9
   COOKE JP, 1991, CIRCULATION, V83, P1057, DOI 10.1161/01.CIR.83.3.1057
   COOKE JP, 1992, J CLIN INVEST, V90, P1168, DOI 10.1172/JCI115937
   CREAGER MA, 1992, J CLIN INVEST, V90, P1248, DOI 10.1172/JCI115987
   Cunha TF, 2017, J APPL PHYSIOL, V122, P817, DOI 10.1152/japplphysiol.00182.2016
   De Angelis K, 2012, AM J PHYSIOL-REG I, V302, pR950, DOI 10.1152/ajpregu.00450.2011
   de Moura RF, 2009, BRIT J NUTR, V101, P1178, DOI 10.1017/S0007114508066774
   Doutreleau S, 2006, INT J SPORTS MED, V27, P567, DOI 10.1055/s-2005-865847
   Eckel RH, 2004, CIRCULATION, V110, P2968, DOI 10.1161/01.CIR.0000140086.88453.9A
   Emter CA, 2005, AM J PHYSIOL-HEART C, V289, pH2030, DOI 10.1152/ajpheart.00526.2005
   Fletcher GF, 1996, CIRCULATION, V94, P857, DOI 10.1161/01.CIR.94.4.857
   Forjaz CLM, 2000, BLOOD PRESS MONIT, V5, P255, DOI 10.1097/00126097-200010000-00002
   Frayn KN, 2006, ESSAYS BIOCHEM, V42, P89, DOI 10.1042/bse0420089
   Fu WJJ, 2005, J NUTR, V135, P714, DOI 10.1093/jn/135.4.714
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Garcia VP, 2016, LIFE SCI, V157, P125, DOI 10.1016/j.lfs.2016.06.006
   GIRERD XJ, 1990, CIRC RES, V67, P1301, DOI 10.1161/01.RES.67.6.1301
   Gomes VA, 2008, NITRIC OXIDE-BIOL CH, V19, P345, DOI 10.1016/j.niox.2008.08.005
   Gornik HL, 2004, J NUTR, V134, p2880S, DOI 10.1093/jn/134.10.2880S
   Grundy SM, 2002, CIRCULATION, V105, P2696, DOI 10.1161/01.CIR.0000020650.86137.84
   Grundy SM, 1999, MED SCI SPORT EXER, V31, P1493, DOI 10.1097/00005768-199911000-00001
   Hambrecht R, 2000, J AM COLL CARDIOL, V35, P706, DOI 10.1016/S0735-1097(99)00602-6
   Ibrahim MA, 2014, EUR J PHARMACOL, V724, P204, DOI 10.1016/j.ejphar.2013.12.024
   Iiyama K, 1996, AM HEART J, V132, P779, DOI 10.1016/S0002-8703(96)90311-7
   Ishiyama N, 2006, AM J PHYSIOL-ENDOC M, V290, pE540, DOI 10.1152/ajpendo.00032.2005
   Jin R, 2014, NUTRIENTS, V6, P3187, DOI 10.3390/nu6083187
   Joyner MJ, 2009, J PHYSIOL-LONDON, V587, P5551, DOI 10.1113/jphysiol.2009.179432
   Kawano T, 2003, LIFE SCI, V73, P3017, DOI 10.1016/j.lfs.2003.06.004
   Kim HY, 2010, BRIT J NUTR, V103, P502, DOI 10.1017/S0007114509991978
   Kulics JM, 1999, AM J PHYSIOL-HEART C, V276, pH27, DOI 10.1152/ajpheart.1999.276.1.H27
   Lakka TA, 2007, APPL PHYSIOL NUTR ME, V32, P76, DOI 10.1139/h06-113
   Lehman JJ, 2000, J CLIN INVEST, V106, P847, DOI 10.1172/JCI10268
   Lucotti P, 2009, METABOLISM, V58, P1270, DOI 10.1016/j.metabol.2009.03.029
   Madani Z, 2012, INT J MOL MED, V29, P311, DOI 10.3892/ijmm.2011.836
   Mahmoud MF, 2012, ARCH PHARM RES, V35, P155, DOI 10.1007/s12272-012-0117-8
   Mann S, 2014, SPORTS MED, V44, P211, DOI 10.1007/s40279-013-0110-5
   Matravadia S, 2016, AM J PHYSIOL-REG I, V310, pR619, DOI 10.1152/ajpregu.00297.2015
   Medeiros RF, 2016, J APPL PHYSIOL, V121, P289, DOI 10.1152/japplphysiol.00369.2015
   Miczke A, 2015, INT J CLIN EXP MED, V8, P10358
   MONCADA S, 1993, NEW ENGL J MED, V329, P2002
   Paula GSM, 2010, J PHYSIOL-LONDON, V588, P1635, DOI 10.1113/jphysiol.2009.185322
   Mora S, 2007, CIRCULATION, V116, P2110, DOI 10.1161/CIRCULATIONAHA.107.729939
   Morris M, 2012, CLIN EXP PHARMACOL P, V39, P57, DOI 10.1111/j.1440-1681.2011.05636.x
   Muiesan ML, 2008, J HYPERTENS, V26, P1612, DOI 10.1097/HJH.0b013e328304b083
   Murias JM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059678
   Nade VS, 2012, INDIAN J PHARMACOL, V44, P688, DOI 10.4103/0253-7613.103248
   Naqvi TZ, 2009, CARDIOVASC ULTRASOUN, V7, DOI 10.1186/1476-7120-7-32
   Paolisso G, 1997, METABOLISM, V46, P1068, DOI 10.1016/S0026-0495(97)90280-8
   Park MH, 2012, OBES REV, V13, P985, DOI 10.1111/j.1467-789X.2012.01015.x
   Powers SK, 2002, CURR OPIN CARDIOL, V17, P495, DOI 10.1097/00001573-200209000-00009
   Reagan-Shaw S, 2008, FASEB J, V22, P659, DOI 10.1096/fj.07-9574LSF
   ROSS R, 1993, NATURE, V362, P801, DOI 10.1038/362801a0
   Roveda F, 2003, J AM COLL CARDIOL, V42, P854, DOI 10.1016/S0735-1097(03)00831-3
   Siani A, 2000, AM J HYPERTENS, V13, P547, DOI 10.1016/S0895-7061(99)00233-2
   Smith S C Jr, 2000, Circulation, V101, P111
   Souza LL, 2011, J ENDOCRINOL, V211, P65, DOI 10.1530/JOE-11-0142
   Suga A, 2000, AM J PHYSIOL-ENDOC M, V278, pE677, DOI 10.1152/ajpendo.2000.278.4.E677
   SUN D, 1994, J APPL PHYSIOL, V76, P2241, DOI 10.1152/jappl.1994.76.5.2241
   Sun LP, 2017, MOLECULES, V22, DOI 10.3390/molecules22030350
   Szostak J, 2011, CLIN SCI, V121, P91, DOI 10.1042/CS20100520
   Thomas DR, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002968.pub2
   Thompson PD, 2003, ARTERIOSCL THROM VAS, V23, pE42, DOI 10.1161/01.ATV.0000089628.63625.D4
   Tsikas D, 2000, FEBS LETT, V478, P1, DOI 10.1016/S0014-5793(00)01686-0
   Umpierre D, 2011, JAMA-J AM MED ASSOC, V305, P1790, DOI 10.1001/jama.2011.576
   Varnam A., 1995, Meat and Meat Products: Technology, Chemistry and Microbiology, V3
   da Motta NAV, 2013, J PHARMACOL SCI, V123, P47, DOI 10.1254/jphs.13016FP
   Vita JA, 2002, CIRCULATION, V106, P640, DOI 10.1161/01.CIR.0000028581.07992.56
   Way KL, 2016, DIABETES METAB J, V40, P253
   Whelton SP, 2002, ANN INTERN MED, V136, P493, DOI 10.7326/0003-4819-136-7-200204020-00006
   Wilkes JJ, 2003, DIABETES, V52, P1904, DOI 10.2337/diabetes.52.8.1904
   Wilson AM, 2007, CIRCULATION, V116, P188, DOI 10.1161/CIRCULATIONAHA.106.683656
   Wu ZD, 1999, CELL, V98, P115, DOI 10.1016/S0092-8674(00)80611-X
   Yoo S, 2017, NUTRIENTS, V9, DOI 10.3390/nu9010011
NR 88
TC 12
Z9 13
U1 0
U2 6
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD JUL
PY 2017
VL 118
IS 1
BP 1
EP 10
DI 10.1017/S0007114517001702
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FG0VT
UT WOS:000409501300001
PM 28799895
OA Bronze
DA 2025-06-11
ER

PT J
AU Achike, FI
   To, NHP
   Wang, HD
   Kwan, CY
AF Achike, Francis I.
   To, Nim-Hin Peter
   Wang, Huide
   Kwan, Chiu-Yin
TI Obesity, metabolic syndrome, adipocytes and vascular function: A
   holistic viewpoint
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Review
DE diabetes mellitus; metabolic syndrome; obesity; perivascular adipose
   tissue; vascular reactivity
ID PERIVASCULAR ADIPOSE-TISSUE; HYPOTHALAMIC NEUROPEPTIDE-Y; GROWTH-HORMONE
   SECRETAGOGUE; ANGIOTENSIN-II; INFLAMMATORY CYTOKINES;
   INSULIN-RESISTANCE; EPIDEMIOLOGIC DATA; ADIPONECTIN LEVELS; OXIDATIVE
   STRESS; WEIGHT-LOSS
AB P>1. Obesity is a metabolic disease of pandemic proportions largely arising from positive energy balance, a consequence of sedentary lifestyle, conditioned by environmental and genetic factors. Several central and peripheral neurohumoral factors (the major ones being the anorectic adipokines leptin and adiponecin and the orexigenic gut hormone ghrelin) acting on the anorectic (pro-opiomelanocortin and cocaine- and amphetamine-regulated transcript) and orexigenic (neuropeptide Y and agouti gene-related protein) neurons regulate energy balance. These neurons, mainly in the arcuate nucleus of the hypothalamus, project to parts of the brain modulating functions such as wakefulness, autonomic function and learning. A tilt in the anorectic-orexigenic balance, perhaps determined genetically, leads to obesity.
   2. Excess fat deposition requires space, created by adipocyte (hypertrophy and hyperplasia) and extracellular matrix (ECM) remodelling. This process is regulated by several factors, including several adipocyte-derived Matrix metalloproteinases and the adipokine cathepsin, which degrades fibronectin, a key ECM protein. Excess fat, also deposited in visceral organs, generates chronic low-grade inflammation that eventually triggers insulin resistance and the associated comorbidities of metabolic syndrome (hypertension, atherosclerosis, dyslipidaemia and diabetes mellitus).
   3. The perivascular adipose tissue (PVAT) has conventionally been considered non-physiological structural tissue, but has recently been shown to serve a paracrine function, including the release of adipose-derived relaxant and contractile factors, akin to the role of the vascular endothelium. Thus, PVAT regulates vascular function in vivo and in vitro, contributing to the cardiovascular pathophysiology of the metabolic syndrome. Defining the mechanism of PVAT regulation of vascular reactivity requires more and better controlled investigations than currently seen in the literature.
C1 [To, Nim-Hin Peter; Kwan, Chiu-Yin] China Med Univ, Vasc Biol Res Grp, Taichung, Taiwan.
   [Achike, Francis I.] Int Med Univ, Kuala Lumpur 57000, Malaysia.
   [Wang, Huide] Brock Univ, St Catharines, ON L2S 3A1, Canada.
C3 China Medical University Taiwan; International Medical University
   Malaysia; Brock University
RP Kwan, CY (corresponding author), China Med Univ & Hosp, Vasc Biol Res Grp, 91 Hsue Shih Rd, Taichung 40402, Taiwan.
EM kwancy@mail.cmu.edu.tw
RI Achike, Francis/AAH-5695-2021
CR Ajay M, 2007, PHARMACOL RES, V55, P385, DOI 10.1016/j.phrs.2007.01.007
   Alleva DG, 2002, J LEUKOCYTE BIOL, V71, P677
   [Anonymous], 1999, WHO TECHN REP SER
   ANTRAS J, 1989, BIOL CELL, V66, P247, DOI 10.1016/0248-4900(89)90177-9
   Atcha Z, 2009, PSYCHOPHARMACOLOGY, V206, P415, DOI 10.1007/s00213-009-1620-6
   Balasubramaniam A, 2003, CURR PHARM DESIGN, V9, P1165, DOI 10.2174/1381612033454955
   Berg AH, 2004, AM J PHYSIOL-ENDOC M, V287, pE1178, DOI 10.1152/ajpendo.00002.2004
   Berna MJ, 2007, CURR OPIN PHARMACOL, V7, P583, DOI 10.1016/j.coph.2007.09.011
   Bonnard C, 2008, DIABETES METAB, V34, P52, DOI 10.1016/j.diabet.2007.09.006
   Bouloumié A, 2001, DIABETES, V50, P2080, DOI 10.2337/diabetes.50.9.2080
   Bray G.A., 1998, Harrisons Principles of Internal Medicine, V14th, P454
   Brekken Rolf A., 2001, Matrix Biology, V19, P816
   Chavey C, 2003, J BIOL CHEM, V278, P11888, DOI 10.1074/jbc.M209196200
   Chin LC, 2007, VASC PHARMACOL, V46, P223, DOI 10.1016/j.vph.2006.10.005
   Christensen R, 2007, ANN RHEUM DIS, V66, P433, DOI 10.1136/ard.2006.065904
   Chua CB, 2010, 16 WORLD C BAS CLIN
   Cone RD, 2005, NAT NEUROSCI, V8, P571, DOI 10.1038/nn1455
   Considine RV, 1996, NEW ENGL J MED, V334, P292, DOI 10.1056/NEJM199602013340503
   Coppola A, 2009, INT J CARDIOL, V134, P414, DOI 10.1016/j.ijcard.2007.12.087
   Cowley MA, 2003, NEURON, V37, P649, DOI 10.1016/S0896-6273(03)00063-1
   Cowley MA, 2001, NATURE, V411, P480, DOI 10.1038/35078085
   DALLMAN MF, 1984, AM J PHYSIOL, V246, pR1, DOI 10.1152/ajpregu.1984.246.1.R1
   Dave GS, 2007, CELL MOL BIOL, V53, P68, DOI 10.1170/T820
   de Groot AA, 2004, J CARDIOVASC PHARM, V43, P154, DOI 10.1097/00005344-200401000-00023
   Degawa-Yamauchi M, 2003, J CLIN ENDOCR METAB, V88, P5452, DOI 10.1210/jc.2002-021808
   DEYEBENES EG, 1995, BRAIN RES, V674, P112, DOI 10.1016/0006-8993(94)01429-L
   Dhillo WS, 2007, THYROID, V17, P433, DOI 10.1089/thy.2007.0018
   Díez JJ, 2003, EUR J ENDOCRINOL, V148, P293, DOI 10.1530/eje.0.1480293
   Dorland's Pocket Medical Dictionary, 1995, DORLANDS POCKET MED, P581
   Egger G, 1997, BRIT MED J, V315, P477, DOI 10.1136/bmj.315.7106.477
   Eknoyan G, 2008, NEPHROL DIAL TRANSPL, V23, P47, DOI 10.1093/ndt/gfm517
   Engeli S, 2003, INT J BIOCHEM CELL B, V35, P807, DOI 10.1016/S1357-2725(02)00311-4
   Eringa EC, 2007, MICROCIRCULATION, V14, P389, DOI 10.1080/10739680701303584
   Fang X, 2006, BIOCHEM SOC T, V34, P798, DOI 10.1042/BST0340798
   Fardoun RZ, 2007, CLIN EXP HYPERTENS, V29, P135, DOI 10.1080/10641960701361601
   Ferder L, 2006, CURR HYPERTENS REP, V8, P191, DOI 10.1007/s11906-006-0050-7
   Fernández-Alfonso MS, 2004, HYPERTENSION, V44, P255, DOI 10.1161/01.HYP.0000140056.64321.f9
   Frühbeck G, 1999, DIABETES, V48, P903, DOI 10.2337/diabetes.48.4.903
   Fumeron F, 2004, DIABETES, V53, P1150, DOI 10.2337/diabetes.53.4.1150
   Gao YJ, 2007, BRIT J PHARMACOL, V151, P323, DOI 10.1038/sj.bjp.0707228
   Gao YJ, 2007, CURR PHARM DESIGN, V13, P2185
   Gao YJ, 2006, CARDIOVASC RES, V71, P363, DOI 10.1016/j.cardiores.2006.03.013
   Green Dina E, 2007, Clin Cornerstone, V8, P58
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Haffner S, 2003, CIRCULATION, V108, P1541, DOI 10.1161/01.CIR.0000088845.17586.EC
   Halberg N, 2008, ENDOCRIN METAB CLIN, V37, P753, DOI 10.1016/j.ecl.2008.07.002
   Hall J E, 2000, Curr Hypertens Rep, V2, P139, DOI 10.1007/s11906-000-0073-4
   Hall JE, 2000, BRAZ J MED BIOL RES, V33, P605, DOI 10.1590/S0100-879X2000000600001
   Henrichot E, 2005, ARTERIOSCL THROM VAS, V25, P2594, DOI 10.1161/01.ATV.0000188508.40052.35
   Hoang QV, 2003, J NEUROPHYSIOL, V90, P693, DOI 10.1152/jn.00001.2003
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Inui A, 2004, FASEB J, V18, P439, DOI 10.1096/fj.03-0641rev
   JACOBOWITZ DM, 1978, P NATL ACAD SCI USA, V75, P6300, DOI 10.1073/pnas.75.12.6300
   Jerlhag E, 2007, ADDICT BIOL, V12, P6, DOI 10.1111/j.1369-1600.2006.00041.x
   Jerlhag E, 2006, ADDICT BIOL, V11, P45, DOI 10.1111/j.1369-1600.2006.00002.x
   Kadowaki T, 2001, Nihon Yakurigaku Zasshi, V118, P321
   Kalra SP, 2007, PEPTIDES, V28, P413, DOI 10.1016/j.peptides.2006.08.039
   Kamegai J, 2000, ENDOCRINOLOGY, V141, P4797, DOI 10.1210/en.141.12.4797
   Kaneto Hideaki, 2004, Rev Diabet Stud, V1, P165, DOI 10.1900/RDS.2004.1.165
   Katra B, 2010, DIABETES TECHNOL THE, V12, P313, DOI 10.1089/dia.2009.0159
   Knudson JD, 2005, AM J PHYSIOL-HEART C, V289, pH48, DOI 10.1152/ajpheart.01159.2004
   Kojima M, 1999, NATURE, V402, P656, DOI 10.1038/45230
   Kralisch S, 2007, EUR J ENDOCRINOL, V156, P257, DOI 10.1530/eje.1.02328
   Kwan CY, 2010, ACTA PHARMACOL SIN, V31, P1022, DOI 10.1038/aps.2010.148
   Lastra G, 2007, ANTIOXID REDOX SIGN, V9, P943, DOI 10.1089/ars.2007.1615
   Lean MEJ, 2000, P NUTR SOC, V59, P331, DOI 10.1017/S0029665100000379
   Lee CD, 1999, AM J CLIN NUTR, V69, P373
   Lee RMKW, 2009, CAN J PHYSIOL PHARM, V87, P944, DOI [10.1139/Y09-088, 10.1139/y09-088]
   Lee RMKW, 2009, J HYPERTENS, V27, P782, DOI 10.1097/HJH.0b013e328324ed86
   Lembo G, 2000, DIABETES, V49, P293, DOI 10.2337/diabetes.49.2.293
   Lin Y, 2001, J BIOL CHEM, V276, P42077, DOI 10.1074/jbc.M107101200
   Löhn M, 2002, FASEB J, V16, P1057, DOI 10.1096/fj.02-0024com
   MANTZOROS CS, 2000, J CLIN EDNOCRINOL ME, V85, P4033
   McTernan CL, 2002, LANCET, V359, P46, DOI 10.1016/S0140-6736(02)07281-1
   Neary NM, 2004, J CLIN ENDOCR METAB, V89, P2832, DOI 10.1210/jc.2003-031768
   Nigro J, 2006, ENDOCR REV, V27, P242, DOI 10.1210/er.2005-0007
   Prentice AM, 2006, INT J EPIDEMIOL, V35, P93, DOI 10.1093/ije/dyi272
   Rahmouni K, 2005, HYPERTENSION, V45, P9, DOI 10.1161/01.HYP.0000151325.83008.b4
   Ravussin E, 2000, BRIT J NUTR, V83, pS17
   Reaven G, 1988, DIABETES, V37, P124
   Ritchie SA, 2004, CLIN SCI, V107, P519, DOI 10.1042/CS20040190
   Ruetsch O, 2005, ENCEPHALE, V31, P507
   Schalkwijk CG, 2005, CLIN SCI, V109, P143, DOI 10.1042/CS20050025
   Shariat-Madar B, 2010, DIABET METAB SYND OB, V3, P67
   Shintani M, 2001, DIABETES, V50, P227, DOI 10.2337/diabetes.50.2.227
   Silswal N, 2005, BIOCHEM BIOPH RES CO, V334, P1092, DOI 10.1016/j.bbrc.2005.06.202
   Singer G, 2007, MICROCIRCULATION, V14, P375, DOI 10.1080/10739680701283158
   SOLTIS EE, 1991, CLIN EXP HYPERTENS, V275, P681
   Steppan CM, 2001, NATURE, V409, P307, DOI 10.1038/35053000
   Taleb S, 2006, ENDOCRINOLOGY, V147, P4950, DOI 10.1210/en.2006-0386
   Tartare-Deckert S, 2001, J BIOL CHEM, V276, P22231, DOI 10.1074/jbc.M010634200
   Terán-García M, 2007, APPL PHYSIOL NUTR ME, V32, P89, DOI 10.1139/h06-102
   Teske JA, 2010, ACTA PHYSIOL, V198, P303, DOI 10.1111/j.1748-1716.2010.02075.x
   Tian L, 2010, ENDOCRINOLOGY, V151, P3049, DOI 10.1210/en.2010-0068
   Tschöp M, 2001, DIABETES, V50, P707, DOI 10.2337/diabetes.50.4.707
   Tschöp M, 2001, J ENDOCRINOL INVEST, V24, pRC19, DOI 10.1007/BF03351037
   Tsuchida A, 2005, DIABETES, V54, P3358, DOI 10.2337/diabetes.54.12.3358
   Tsuneki H, 2010, ACTA PHYSIOL, V198, P335, DOI 10.1111/j.1748-1716.2009.02008.x
   Ukkola O, 2002, J MOL MED, V80, P696, DOI 10.1007/s00109-002-0378-7
   Unger RH, 2002, ANNU REV MED, V53, P319, DOI 10.1146/annurev.med.53.082901.104057
   Valsamakis G, 2004, METABOLISM, V53, P430, DOI 10.1016/j.metabol.2003.11.022
   Van Guilder GP, 2005, AM J PHYSIOL-ENDOC M, V289, pE807, DOI 10.1152/ajpendo.00072.2005
   Wieland HA, 2000, EXPERT OPIN INV DRUG, V9, P1327, DOI 10.1517/13543784.9.6.1327
   Wilding JPH, 1997, J ENDOCRINOL, V152, P365, DOI 10.1677/joe.0.1520365
   Wolf G, 2003, NUTR REV, V61, P290, DOI 10.1301/nr.2003.aug.290-292
   Wong NL, 2010, REGUL PEPTIDES, V163, P113, DOI 10.1016/j.regpep.2010.04.003
   Yang L, 2009, J NEUROSCI, V29, P179, DOI 10.1523/JNEUROSCI.4379-08.2009
   Yasuda T, 2003, NEUROSCI LETT, V349, P75, DOI 10.1016/S0304-3940(03)00789-4
   ZARJEVSKI N, 1993, ENDOCRINOLOGY, V133, P1753, DOI 10.1210/en.133.4.1753
   Zelissen PMJ, 2005, DIABETES OBES METAB, V7, P755, DOI 10.1111/j.1463-1326.2005.00468.x
   Zhang JV, 2005, SCIENCE, V310, P996, DOI 10.1126/science.1117255
   Zhang L, 2009, J NEUROPHYSIOL, V101, P2741, DOI 10.1152/jn.91183.2008
NR 112
TC 93
Z9 107
U1 0
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1870
EI 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD JAN
PY 2011
VL 38
IS 1
BP 1
EP 10
DI 10.1111/j.1440-1681.2010.05460.x
PG 10
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 700RX
UT WOS:000285763100001
PM 21083697
DA 2025-06-11
ER

PT J
AU Adeyemi, DH
   Odetayo, AF
   Hamed, MA
   Akhigbe, RE
AF Adeyemi, D. H.
   Odetayo, A. F.
   Hamed, M. A.
   Akhigbe, R. E.
TI Impact of COVID 19 on erectile function
SO AGING MALE
LA English
DT Review
DE Coronavirus; SARS-CoV-2; COVID-19; endothelial dysfunction; erectile
   dysfunction; testosterone
ID RESPIRATORY SYNDROME CORONAVIRUS; TUMOR-NECROSIS-FACTOR;
   CARDIOVASCULAR-DISEASE; SEXUAL DYSFUNCTION; TESTOSTERONE LEVELS;
   ANGIOTENSIN-II; METABOLIC SYNDROME; PENILE ERECTION; UNITED-STATES;
   MENTAL-HEALTH
AB Purpose: COVID-19, a novel infection, presented with several complications, including socioeconomical and reproductive health challenges such as erectile dysfunction (ED). The present review summarizes the available shreds of evidence on the impact of COVID-19 on ED. Materials and methods: All published peer-reviewed articles from the onset of the COVID-19 outbreak to date, relating to ED, were reviewed. Results: Available pieces of evidence that ED is a consequence of COVID-19 are convincing. COVID-19 and ED share common risk factors such as disruption of vascular integrity, cardiovascular disease (CVD), cytokine storm, diabetes, obesity, and chronic kidney disease (CKD). COVID-19 also induces impaired pulmonary haemodynamics, increased ang II, testicular damage and low serum testosterone, and reduced arginine-dependent NO bioavailability that promotes reactive oxygen species (ROS) generation and endothelial dysfunction, resulting in ED. In addition, COVID-19 triggers psychological/mental stress and suppresses testosterone-dependent dopamine concentration, which contributes to incident ED. Conclusions: In conclusion, COVID-19 exerts a detrimental effect on male reproductive function, including erectile function. This involves a cascade of events from multiple pathways. As the pandemic dwindles, identifying the long-term effects of COVID-19-induced ED, and proffering adequate and effective measures in militating against COVID-19-induced ED remains pertinent.
C1 [Adeyemi, D. H.] Osun State Univ, Coll Hlth Sci, Dept Physiol, Fac Basic Med Sci, Osogbo, Nigeria.
   [Odetayo, A. F.] Univ Ilorin, Dept Physiol, Ilorin, Nigeria.
   [Odetayo, A. F.; Hamed, M. A.; Akhigbe, R. E.] Oasis Grace Hosp, Reprod Biol & Toxicol Res Lab, Osogbo, Osun State, Nigeria.
   [Hamed, M. A.] Brainwill Labs, Osogbo, Nigeria.
   [Hamed, M. A.] Afe Babalola Univ, Coll Med & Hlth Sci, Dept Med Lab Sci, Ado Ekiti, Nigeria.
   [Akhigbe, R. E.] Ladoke Akintola Univ Technol, Dept Physiol, Ogbomosho, Oyo State, Nigeria.
C3 University of Ilorin
RP Akhigbe, RE (corresponding author), Oasis Grace Hosp, Reprod Biol & Toxicol Res Lab, Osogbo, Osun State, Nigeria.; Akhigbe, RE (corresponding author), Ladoke Akintola Univ Technol, Dept Physiol, Ogbomosho, Oyo State, Nigeria.
EM akhigberoland@gmail.com
RI Odetayo, Adeyemi/JNR-7505-2023; Hamed, Moses/CAH-6613-2022
OI Akhigbe, Roland/0000-0002-3874-5927; Odetayo,
   Adeyemi/0000-0002-9089-7610; Hamed, Moses/0000-0003-3378-6794
CR Aboumohamed A, 2021, BMC SURG, V21, DOI 10.1186/s12893-021-01067-9
   Aitken RJ, 2021, ANDROLOGY-US, V9, P48, DOI 10.1111/andr.12859
   Ajayi A. F., 2021, Asian Journal of Epidemiology, V14, P11, DOI 10.3923/aje.2021.11.21
   Ajayi AF, 2020, ANDROLOGY-US, V8, DOI 10.1111/andr.12717
   Ajayi AF, 2020, ANDROLOGIA, V52, DOI 10.1111/and.13672
   Akhigbe RE., 2022, FRONT REPROD HLTH, V4, DOI DOI 10.3389/FRPH.2022.782915
   Akhigbe R, 2021, LIPIDS HEALTH DIS, V20, DOI 10.1186/s12944-021-01435-7
   Akhigbe RE, 2021, BIOMED RES INT, V2021, DOI 10.1155/2021/9872109
   Akhigbe RE, 2021, CHEM BIOL LETT, V8, P213
   Akhigbe Roland Eghoghosoa, 2020, Asian Pacific Journal of Reproduction, V9, P211, DOI 10.4103/2305-0500.294662
   Anand P, 2020, ELIFE, V9, DOI 10.7554/eLife.58603
   Anantharaman P, 2007, ADV CHRONIC KIDNEY D, V14, P119, DOI 10.1053/j.ackd.2007.01.002
   Andersson KE, 2003, J UROLOGY, V170, pS6, DOI 10.1097/01.ju.0000075362.08363.a4
   Angst J, 1998, INT CLIN PSYCHOPHARM, V13, pS1, DOI 10.1097/00004850-199807006-00001
   [Anonymous], 2020, CDEMA guidelines for emergency shelters and shelterees during COVID-19
   Bae S, 2021, HEART, V107, P373, DOI 10.1136/heartjnl-2020-317901
   Bakr AM, 2022, INT J IMPOT RES, V34, P145, DOI 10.1038/s41443-021-00504-w
   BELL L, 1990, AM J PATHOL, V137, P7
   Beusterien KM, 1996, J AM SOC NEPHROL, V7, P763
   Billups KL, 2005, AM J CARDIOL, V96, p57M, DOI 10.1016/j.amjcard.2005.10.007
   Bray BD, 2012, QJM-INT J MED, V105, P1097, DOI 10.1093/qjmed/hcs143
   BROCK GB, 1993, DRUG SAFETY, V8, P414, DOI 10.2165/00002018-199308060-00003
   Bronte V, 2005, NAT REV IMMUNOL, V5, P641, DOI 10.1038/nri1668
   Burhamah W, 2020, J AFFECT DISORDERS, V277, P977, DOI 10.1016/j.jad.2020.09.014
   Burnett Arthur L, 2006, J Clin Hypertens (Greenwich), V8, P53
   Burrell LM, 2004, TRENDS ENDOCRIN MET, V15, P166, DOI 10.1016/j.tem.2004.03.001
   Cardone M, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.01131
   Carvalho J, 2020, J SEX MED, V17, P1212, DOI 10.1016/j.jsxm.2020.05.024
   Çayan S, 2020, AGING MALE, V23, P1493, DOI 10.1080/13685538.2020.1807930
   Chan JFW, 2020, EMERG MICROBES INFEC, V9, P221, DOI 10.1080/22221751.2020.1719902
   Chen JW, 2020, AGING CELL, V19, DOI 10.1111/acel.13168
   Chen T, 2021, SEX MED-UK, V9, DOI 10.1016/j.esxm.2021.100340
   Chen Y, 2020, J MED VIROL, V92, P418, DOI 10.1002/jmv.25681
   Chen Y, 2020, BIOCHEM BIOPH RES CO, V525, P135, DOI 10.1016/j.bbrc.2020.02.071
   Chiappetta S, 2020, INT J OBESITY, V44, P1790, DOI 10.1038/s41366-020-0597-4
   Chu KY, 2022, SEX MED-UK, V10, DOI 10.1016/j.esxm.2021.100478
   Cito G, 2021, UROLOGY, V147, P37, DOI 10.1016/j.urology.2020.06.101
   Cocci A, 2020, INT J IMPOT RES, V32, P480, DOI 10.1038/s41443-020-0270-4
   Collins RL, 2017, PEDIATRICS, V140, pS162, DOI 10.1542/peds.2016-1758X
   Coutard B, 2020, ANTIVIR RES, V176, DOI 10.1016/j.antiviral.2020.104742
   Cranston-Cuebas M.A., 1990, Annual Review of Sex Research, V1, P119
   Culha MG, 2021, INT J IMPOT RES, V33, P102, DOI 10.1038/s41443-020-00381-9
   Czeisler MÉ, 2020, MMWR-MORBID MORTAL W, V69, P1250, DOI 10.15585/mmwr.mm6936a4
   D'Agostino P, 1999, ANN NY ACAD SCI, V876, P426, DOI 10.1111/j.1749-6632.1999.tb07667.x
   de Oliveira L, 2021, CURR SEX HEALTH REP, V13, P76, DOI 10.1007/s11930-021-00309-4
   de Tejada IS, 2005, J SEX MED, V2, P26, DOI 10.1111/j.1743-6109.2005.20103.x
   de Wit E, 2016, NAT REV MICROBIOL, V14, P523, DOI 10.1038/nrmicro.2016.81
   Dean MJ, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.695972
   Dhainaut JF, 2005, CLIN INFECT DIS, V41, pS481, DOI 10.1086/432001
   Dhindsa S, 2004, J CLIN ENDOCR METAB, V89, P5462, DOI 10.1210/jc.2004-0804
   Di Stasi V, 2022, J ENDOCRINOL INVEST, V45, P639, DOI 10.1007/s40618-021-01682-6
   Diaz-Arjonilla M, 2009, INT J IMPOT RES, V21, P89, DOI 10.1038/ijir.2008.42
   Didion SP, 2003, STROKE, V34, P2038, DOI 10.1161/01.STR.0000081225.46324.AA
   Donoghue M, 2000, CIRC RES, V87, pE1, DOI 10.1161/01.res.87.5.e1
   Dutta S, 2021, CHEM BIOL LETT, V8, P192
   Edey MM, 2017, FRONT MED-LAUSANNE, V4, DOI 10.3389/fmed.2017.00032
   Eroglu U, 2022, J SEX MED, V19, P182, DOI 10.1016/j.jsxm.2021.11.013
   Esposito K, 2005, INT J IMPOT RES, V17, P391, DOI 10.1038/sj.ijir.3901333
   Esposito K, 2011, CLIN PHARMACOL THER, V90, P169, DOI 10.1038/clpt.2011.91
   Esposito K, 2005, DIABETES CARE, V28, P1201, DOI 10.2337/diacare.28.5.1201
   Facio FN Jr, 2020, REV ASSOC MED BRAS, V66, P1613, DOI 10.1590/1806-9282.66.12.1613
   Fang D, 2021, SEX MED-UK, V9, DOI 10.1016/j.esxm.2020.100293
   Ferrario CM, 2005, CIRCULATION, V111, P2605, DOI 10.1161/CIRCULATIONAHA.104.510461
   Fiorentino G, 2021, ECLINICALMEDICINE, V40, DOI 10.1016/j.eclinm.2021.101125
   Flaifel A, 2021, ARCH PATHOL LAB MED, V145, P8, DOI 10.5858/arpa.2020-0487-LE
   Foley RN, 1998, J NEPHROL, V11, P239
   Geneva WHO, 2020, GLOBAL HLTH ESTIMATE
   Giagulli VA, 2021, ANDROLOGY-US, V9, P53, DOI 10.1111/andr.12836
   Giuliano F, 2000, NEUROSCI BIOBEHAV R, V24, P517, DOI 10.1016/S0149-7634(00)00020-8
   Goldstein I, 2000, AM J CARDIOL, V86, p41F
   González F, 2012, STEROIDS, V77, P300, DOI 10.1016/j.steroids.2011.12.003
   Graham RL, 2013, NAT REV MICROBIOL, V11, P836, DOI 10.1038/nrmicro3143
   Hartnett KP, 2020, MMWR-MORBID MORTAL W, V69, P699, DOI 10.15585/mmwr.mm6923e1
   Hatziagelaki E, 2020, EXP CLIN ENDOCR DIAB, V128, P723, DOI 10.1055/a-0992-9114
   Herrmann M, 2002, ANN NY ACAD SCI, V966, P166, DOI 10.1111/j.1749-6632.2002.tb04213.x
   Honce R, 2020, MBIO, V11, DOI 10.1128/mBio.03341-19
   Hong CY, 2004, MOL CELL BIOL, V24, P2593, DOI 10.1128/MCB.24.7.2593-2604.2004
   Hou-Yu A., 1984, FED PROC
   Hull EM, 2004, PHYSIOL BEHAV, V83, P291, DOI 10.1016/j.physbeh.2004.08.018
   Hulme KD, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00861
   Ibarra François Peinado, 2020, Int. braz j urol., V46, P104, DOI 10.1590/S1677-5538.IBJU.2020.S116
   Ige S F, 2013, Pathophysiology, V20, P269, DOI 10.1016/j.pathophys.2013.04.002
   Isidori AM, 2014, EUR UROL, V65, P99, DOI 10.1016/j.eururo.2013.08.048
   Jackson G, 1997, BMJ-BRIT MED J, V315, P31, DOI 10.1136/bmj.315.7099.31a
   Jeffery MM, 2020, JAMA INTERN MED, V180, P1328, DOI 10.1001/jamainternmed.2020.3288
   Jensen J, 1999, AM J HYPERTENS, V12, P271, DOI 10.1016/S0895-7061(98)00225-8
   Kahn Marc J., 2013, Cardiovascular & Hematological Disorders - Drug Targets, V13, P83
   Kapoor D, 2007, DIABETES CARE, V30, P911, DOI 10.2337/dc06-1426
   Karagöz MA, 2021, INT J IMPOT RES, V33, P815, DOI 10.1038/s41443-020-00378-4
   Karkin K., 2021, ARCH ITAL UROL ANDRO, V93, P460
   Karsiyakali N, 2021, SEX MED-UK, V9, DOI 10.1016/j.esxm.2020.10.007
   Kato S, 2008, CLIN J AM SOC NEPHRO, V3, P1526, DOI 10.2215/CJN.00950208
   Katz J, 2022, J ENDOCRINOL INVEST, V45, P859, DOI 10.1007/s40618-021-01717-y
   Kidney Disease, 2013, Kidney Int Suppl, V3, P1, DOI DOI 10.1038/KISUP.2012.73
   Le K, 2021, ECON HUM BIOL, V41, DOI 10.1016/j.ehb.2021.100979
   Koolwal A., 2019, J PSYCHOSEX HLTH, V1, P37, DOI [10.1177/2631831818822018, DOI 10.1177/2631831818822018]
   Kory P, 2021, J INTENSIVE CARE MED, V36, P135, DOI 10.1177/0885066620973585
   Kumar M, 2020, J TRANSL MED, V18, DOI 10.1186/s12967-020-02520-8
   Lawrence IG, 1997, NEPHROL DIAL TRANSPL, V12, P741, DOI 10.1093/ndt/12.4.741
   Leal MC, 2009, J ANAT, V214, P736, DOI 10.1111/j.1469-7580.2009.01058.x
   Lesch KP, 1996, SCIENCE, V274, P1527, DOI 10.1126/science.274.5292.1527
   Letko M, 2020, NAT MICROBIOL, V5, P562, DOI [10.1038/s41564-020-0688-y, 10.1101/2020.01.22.915660]
   Li DG, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.8292
   Li F, 2016, ANNU REV VIROL, V3, P237, DOI 10.1146/annurev-virology-110615-042301
   Li MY, 2020, INFECT DIS POVERTY, V9, DOI 10.1186/s40249-020-00662-x
   Li P, 2007, BRIT J NUTR, V98, P237, DOI 10.1017/S000711450769936X
   Lo SP, 2022, INT J IMPOT RES, V34, P138, DOI 10.1038/s41443-021-00483-y
   Lodigiani C, 2020, THROMB RES, V191, P9, DOI 10.1016/j.thromres.2020.04.024
   Loot AE, 2009, J EXP MED, V206, P2889, DOI 10.1084/jem.20090449
   Lu RJ, 2020, LANCET, V395, P565, DOI 10.1016/S0140-6736(20)30251-8
   Lucas R, 2013, FRONT IMMUNOL, V4, DOI 10.3389/fimmu.2013.00228
   Ma L, 2020, medRxiv, DOI [10.1101/2020.03.21.20037267, 10.1101/2020.03.21.20037267, DOI 10.1101/2020.03.21.20037267, 10.1101/2020.03.21.20037267v2]
   Ma L, 2021, J MED VIROL, V93, P456, DOI 10.1002/jmv.26259
   Maiorino MI, 2014, DIABET METAB SYND OB, V7, P95, DOI 10.2147/DMSO.S36455
   Malik J, 2021, J COMMUNITY HOSP INT, V11, P496, DOI 10.1080/20009666.2021.1922133
   Mantovani A, 2020, NUTR METAB CARDIOVAS, V30, P1236, DOI 10.1016/j.numecd.2020.05.014
   Mary KB., 2020, PHYSIOLOGY, V12, P288
   Masters PS, 2006, ADV VIRUS RES, V66, P193, DOI 10.1016/S0065-3527(06)66005-3
   Matsumoto AM, 2002, J GERONTOL A-BIOL, V57, pM76, DOI 10.1093/gerona/57.2.M76
   Matsushita K, 2020, GLOB HEART, V15, DOI 10.5334/gh.814
   Mazzilli R, 2022, J ENDOCRINOL INVEST, V45, P463, DOI 10.1007/s40618-021-01673-7
   McGonagle D, 2020, AUTOIMMUN REV, V19, DOI 10.1016/j.autrev.2020.102537
   McKenna K. E., 1997, Society for Neuroscience Abstracts, V23, P1520
   Melis MR, 2011, NEUROSCI BIOBEHAV R, V35, P939, DOI 10.1016/j.neubiorev.2010.10.014
   Melis MR, 2003, EUR J NEUROSCI, V17, P1266, DOI 10.1046/j.1460-9568.2003.02558.x
   Millet JK, 2014, P NATL ACAD SCI USA, V111, P15214, DOI 10.1073/pnas.1407087111
   Minskaia E, 2006, P NATL ACAD SCI USA, V103, P5108, DOI 10.1073/pnas.0508200103
   Mohamad NV, 2019, AGING MALE, V22, P129, DOI 10.1080/13685538.2018.1482487
   Mollaioli D, 2021, J SEX MED, V18, P35, DOI 10.1016/j.jsxm.2020.10.008
   Morales A, 2000, J UROLOGY, V163, P705, DOI 10.1016/S0022-5347(05)67788-9
   Nehra A, 2001, UROL CLIN N AM, V28, P289, DOI 10.1016/S0094-0143(05)70139-7
   Nelveg-Kristensen KE, 2018, BMC INFECT DIS, V18, DOI 10.1186/s12879-018-3594-7
   Nessaibia I, 2022, INT J IMPOT RES, V34, P117, DOI 10.1038/s41443-021-00494-9
   Neto RP, 2021, SEX MED-UK, V9, DOI 10.1016/j.esxm.2021.100408
   Nobre PJ, 2010, J SEX MED, V7, P1429, DOI 10.1111/j.1743-6109.2009.01656.x
   Ochoa JB, 2001, ANN SURG, V233, P393, DOI 10.1097/00000658-200103000-00014
   Ortiz A, 2021, NEPHROL DIAL TRANSPL, V36, P87, DOI 10.1093/ndt/gfaa314
   Ou XY, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-15562-9
   Ozbek E, 2009, ASIAN J ANDROL, V11, P351, DOI 10.1038/aja.2008.3
   Palmer BF, 2004, ADV CHRONIC KIDNEY D, V11, P342, DOI 10.1053/j.ackd.2004.07.008
   Paneroni M, 2021, J CLIN MED, V10, DOI 10.3390/jcm10122558
   Papadopoulos AD, 2000, NEUROIMMUNOMODULAT, V8, P39, DOI 10.1159/000026451
   Papautsky EL, 2021, J MED INTERNET RES, V23, DOI 10.2196/25446
   Paul BD, 2021, P NATL ACAD SCI USA, V118, DOI 10.1073/pnas.2024358118
   Perlman S, 2009, NAT REV MICROBIOL, V7, P439, DOI 10.1038/nrmicro2147
   Pizzol Damiano, 2016, Int J Adolesc Med Health, V28, P169, DOI 10.1515/ijamh-2015-0003
   Pons S, 2020, CRIT CARE, V24, DOI 10.1186/s13054-020-03062-7
   Pornhub, 2020, COR INS
   Qian ZH, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076469
   Gomes ALQ, 2018, ARCH SEX BEHAV, V47, P1721, DOI 10.1007/s10508-017-1137-8
   Rastrelli G, 2021, ANDROLOGY-US, V9, P88, DOI 10.1111/andr.12821
   Rees CA, 2021, P NATL ACAD SCI USA, V118, DOI 10.1073/pnas.2101708118
   Reis AB, 2010, J MOL HISTOL, V41, P75, DOI 10.1007/s10735-010-9264-8
   Reizine F, 2021, J CLIN IMMUNOL, V41, P515, DOI 10.1007/s10875-020-00920-5
   Rice GI, 2004, BIOCHEM J, V383, P45, DOI 10.1042/BJ20040634
   Rizzo M, 2020, INT J IMPOT RES, V32, P547, DOI 10.1038/s41443-020-0288-7
   Roe K, 2021, J NEUROSCI RES, V99, P2367, DOI 10.1002/jnr.24917
   Saad HM, 2022, ANDROLOGIA, V54, DOI 10.1111/and.14308
   Sacchi A, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10082111
   Saka WA, 2021, BIOMED PHARMACOTHER, V138, DOI 10.1016/j.biopha.2021.111443
   Salama N., 2021, CLIN MED INSIGHT-CAS, V14, p117954762110205
   Salciccia S, 2020, ENDOCRINE, V70, P206, DOI 10.1007/s12020-020-02515-x
   Sansone A, 2021, J ENDOCRINOL INVEST, V44, P223, DOI 10.1007/s40618-020-01350-1
   Sansone Andrea, 2022, Sex Med Rev, V10, P271, DOI 10.1016/j.sxmr.2021.11.001
   Sansone A, 2021, ANDROLOGY-US, V9, P1053, DOI 10.1111/andr.13003
   Sansone A, 2014, ENDOCRINE, V46, P423, DOI 10.1007/s12020-014-0254-6
   Santos RAS, 2003, HYPERTENSION, V41, P737, DOI 10.1161/01.HYP.0000052947.60363.24
   Savica V, 2001, AM J KIDNEY DIS, V38, pS118, DOI 10.1053/ajkd.2001.27418
   Savoia C, 2007, CLIN SCI, V112, P375, DOI 10.1042/CS20060247
   Sawicki SG, 2007, J VIROL, V81, P20, DOI 10.1128/JVI.01358-06
   Schubert M, 2005, J Endocrinol Invest, V28, P23
   Sengupta P, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.746049
   Shilo G, 2020, J SEX MED, V17, P1827, DOI 10.1016/j.jsxm.2020.07.085
   Siddiqi HK, 2020, J HEART LUNG TRANSPL, V39, P405, DOI 10.1016/j.healun.2020.03.012
   Snijder EJ, 2006, J VIROL, V80, P5927, DOI 10.1128/JVI.02501-05
   Song WF, 2014, VIROLOGY, V471, P49, DOI 10.1016/j.virol.2014.10.006
   Steers WD, 2000, NEUROSCI BIOBEHAV R, V24, P507, DOI 10.1016/S0149-7634(00)00019-1
   STEWARTB.M, 1974, METABOLISM, V23, P1065, DOI 10.1016/0026-0495(74)90073-0
   Toniolo A, 2019, REV MED MICROBIOL, V30, P1, DOI 10.1097/MRM.0000000000000155
   Tonyali S, 2020, UROL J, V17, P548, DOI 10.22037/uj.v16i7.6285
   Traish A, 2000, INT J IMPOT RES, V12, pS48, DOI 10.1038/sj.ijir.3900506
   Tsigos C, 1999, J INTERF CYTOK RES, V19, P1271, DOI 10.1089/107999099312948
   Uhel F, 2017, AM J RESP CRIT CARE, V196, P315, DOI 10.1164/rccm.201606-1143OC
   Vaduganathan M, 2020, JAMA-J AM MED ASSOC, V323, P2524, DOI 10.1001/jama.2020.9184
   Vaduganathan M, 2020, NEW ENGL J MED, V382, P1653, DOI 10.1056/NEJMsr2005760
   VANDERPOLL T, 1993, METABOLISM, V42, P303, DOI 10.1016/0026-0495(93)90078-3
   Vaninov Natalie, 2020, Nat Rev Immunol, V20, P277, DOI 10.1038/s41577-020-0305-6
   Vickers C, 2002, J BIOL CHEM, V277, P14838, DOI 10.1074/jbc.M200581200
   Vita G, 1999, KIDNEY INT, V56, P232, DOI 10.1046/j.1523-1755.1999.00511.x
   Wang MY, 2020, FRONT CELL INFECT MI, V10, DOI 10.3389/fcimb.2020.587269
   Ware MR, 1996, PSYCHOPHARMACOL BULL, V32, P530
   Watanabe T, 2005, HYPERTENSION, V45, P163, DOI 10.1161/01.HYP.0000153321.13792.b9
   Witherspoon L, 2020, CUAJ-CAN UROL ASSOC, V14, pE161, DOI 10.5489/cuaj.6631
   Wrapp D, 2020, SCIENCE, V367, P1260, DOI [10.1126/science.abb2507, 10.1101/2020.02.11.944462]
   Wray NR, 2009, BIOL PSYCHIAT, V66, P468, DOI 10.1016/j.biopsych.2009.04.030
   Xiong JQ, 2020, J AFFECT DISORDERS, V277, P55, DOI 10.1016/j.jad.2020.08.001
   Xu XT, 2020, SCI CHINA LIFE SCI, V63, P457, DOI 10.1007/s11427-020-1637-5
   Yan ZP, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9080966
   Yousefi B, 2022, REV RES MED MICROBIO, V33, pE180, DOI 10.1097/MRM.0000000000000265
   Yu J, 2020, FRONT CELL DEV BIOL, V8, DOI 10.3389/fcell.2020.00476
   Zhang HB, 2020, INTENS CARE MED, V46, P586, DOI 10.1007/s00134-020-05985-9
   Zhang J, 2020, PRECIS CLIN MED, V3, P3, DOI 10.1093/pcmedi/pbaa006
   Zhang YF, 2021, J SEX MED, V18, P1843, DOI 10.1016/j.jsxm.2021.06.013
   Zhou Peng, 2020, NATURE, V579, P270, DOI DOI 10.1038/s41586-020-2012-7
   Zhu LJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054994
   Zhu N, 2020, NEW ENGL J MED, V382, P727, DOI [10.1056/NEJMoa2001017, 10.1172/JCI89857]
   Zhu XM, 2014, ANN SURG, V259, P171, DOI 10.1097/SLA.0b013e31828611f8
   Zou X, 2020, FRONT MED-PRC, V14, P185, DOI 10.1007/s11684-020-0754-0
NR 208
TC 29
Z9 29
U1 1
U2 40
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1368-5538
EI 1473-0790
J9 AGING MALE
JI Aging Male
PD DEC 31
PY 2022
VL 25
IS 1
BP 202
EP 216
DI 10.1080/13685538.2022.2104833
PG 15
WC Endocrinology & Metabolism; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Urology & Nephrology
GA 3N2HT
UT WOS:000835973700001
PM 35924485
OA gold
DA 2025-06-11
ER

PT J
AU Atad, OI
   Toker, S
AF Atad, Ofer I. I.
   Toker, Sharon
TI Subjective Workload and the Metabolic Syndrome: An Exploration of the
   Mediating Role of Burnout and the Moderating Effect of Physical Activity
SO INTERNATIONAL JOURNAL OF STRESS MANAGEMENT
LA English
DT Article
DE metabolic syndrome; workload; physical activity; burnout; stress
ID EFFORT-REWARD IMBALANCE; CORONARY-HEART-DISEASE; RISK-FACTORS;
   CARDIOVASCULAR-DISEASE; JOB DEMANDS; LIFE-STYLE; FOLLOW-UP; STRESS;
   ADULTS; METAANALYSIS
AB In this study, building on Hobfoll's (1989) conservation of resources theory, we aimed to reveal the effect of subjective workload at baseline on the likelihood of developing new-onset of metabolic syndrome (MetS), a cluster of cardiovascular risk factors during follow-up. We also aimed to find out whether an increase in job burnout mediates this association, and whether the extent of engagement in leisure-time physical activity (PA) attenuates the effect of workload on MetS. Using a three-wave longitudinal study design, we followed a sample of 1,966 Israeli employees free of MetS at baseline for 3.5 years on average. We controlled for multiple confounders, including objective workload (i.e., work hours). Subjective workload at baseline was associated with the risk of new-onset of MetS, yet this association was moderated by PA. Specifically, among participants with low PA (37 weekly minutes), a one-point increase in our five-point measure of subjective workload was associated with a 41% increase in risk of new-onset MetS, whereas among those with high PA (258 weekly minutes) it was associated with a 38% reduction in risk. Among participants who engaged in 148 weekly minutes of PA (as recommended by the U.S. Department of Health and Human Services), an increase in workload did not result in an increased risk of developing MetS. We did not find, however, any indication for a mediating effect of job burnout. Our findings suggest that engaging in PA while being overloaded not only protects employees from adverse outcomes but actually reverses the cardiovascular risk.
C1 [Atad, Ofer I. I.] Peres Acad Ctr, Sch Business, Rehovot, Israel.
   [Toker, Sharon] Tel Aviv Univ, Coller Sch Management, Tel Aviv, Israel.
   [Atad, Ofer I. I.] Peres Acad Ctr, Sch Business, Shimon Peres St 10, IL-7610202 Rehovot, Israel.
C3 Tel Aviv University
RP Atad, OI (corresponding author), Peres Acad Ctr, Sch Business, Shimon Peres St 10, IL-7610202 Rehovot, Israel.
EM ofer.atad@gmail.com
RI ; Toker, Sharon/P-5428-2015
OI Atad, Ofer/0000-0002-5678-4022; Toker, Sharon/0000-0001-7621-6607
FU Arie Shirom Foundation [01-2015]; Henry Crown Institute, Tel-Aviv
   University
FX This research was supported by grants from the Arie Shirom Foundation
   (Grant 01-2015 to Ofer I. Atad) and the Henry Crown Institute, Tel-Aviv
   University. The authors would like to thank Itzhak Shapira, Shlomo
   Berliner, and Samuel Melamed for their theoretical contribution and
   financial support throughout the project.
CR Aiken L.S., 1992, MULTIPLE REGRESSION
   Alarcon GM, 2011, J VOCAT BEHAV, V79, P549, DOI 10.1016/j.jvb.2011.03.007
   Almadi T, 2013, PSYCHOPHYSIOLOGY, V50, P821, DOI 10.1111/psyp.12069
   [Anonymous], 2017, STRESS HLTH DISP CON
   [Anonymous], Workplace Stress: A Collective Challenge
   Bolin JH, 2014, J EDUC MEAS, V51, P335, DOI 10.1111/jedm.12050
   Calderwood C, 2021, J MANAGE, V47, P144, DOI 10.1177/0149206320940413
   Canu IG, 2021, SCAND J WORK ENV HEA, V47, P95, DOI 10.5271/sjweh.3935
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Childs E, 2014, FRONT PHYSIOL, V5, DOI 10.3389/fphys.2014.00161
   Cho JJ, 2006, KOREAN J OCCUP ENV M, V18, P209
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cohen J., 2013, APPL MULTIPLE REGRES, DOI [10.4324/9780203774441, DOI 10.1002/0471264385.WEI0219]
   Demerouti E, 2001, J APPL PSYCHOL, V86, P499, DOI 10.1037//0021-9010.86.3.499
   Demerouti E, 2021, EUR J WORK ORGAN PSY, V30, P686, DOI 10.1080/1359432X.2021.1979962
   Demiral Y, 2006, J OCCUP HEALTH, V48, P332, DOI 10.1539/joh.48.332
   Dormann C, 2002, J OCCUP ORGAN PSYCH, V75, P33, DOI 10.1348/096317902167630
   Dunford BB, 2012, J APPL PSYCHOL, V97, P637, DOI 10.1037/a0027060
   Edwards EM, 2012, J OCCUP ENVIRON MED, V54, P1447, DOI 10.1097/JOM.0b013e3182783f27
   Ekelund U, 2016, LANCET, V388, P1302, DOI 10.1016/S0140-6736(16)30370-1
   Esposito K, 2014, ENDOCRINE, V46, P176, DOI 10.1007/s12020-014-0165-6
   Ferrie JE, 2009, INT J EPIDEMIOL, V38, P831, DOI 10.1093/ije/dyp153
   Fleshner M, 2011, STRESS, V14, P498, DOI 10.3109/10253890.2011.596865
   Frese M., 1988, CAUSES COPING CONSEQ, P375, DOI DOI 10.1002/SMI.2460050217
   Froom P, 1999, J CLIN EPIDEMIOL, V52, P731, DOI 10.1016/S0895-4356(99)00070-0
   Frugé AD, 2015, NUTR METAB CARDIOVAS, V25, P535, DOI 10.1016/j.numecd.2015.03.006
   Ganster DC, 2013, J MANAGE, V39, P1085, DOI 10.1177/0149206313475815
   Garbarino S, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0144318
   Garber CE, 2011, MED SCI SPORT EXER, V43, P1334, DOI 10.1249/MSS.0b013e318213fefb
   Geneva WHO, 2020, GLOBAL HLTH ESTIMATE
   Glaser R, 2005, NAT REV IMMUNOL, V5, P243, DOI 10.1038/nri1571
   Goetzel RZ, 2020, AM J HEALTH PROMOT, V34, P490, DOI 10.1177/0890117120917850
   Grant A.M., 2017, Consulting Psychology Journal: Practice and Research, V69, P98, DOI DOI 10.1037/CPB0000086
   Grossi G, 2003, J PSYCHOSOM RES, V55, P309, DOI 10.1016/S0022-3999(02)00633-5
   Grundy SM, 2018, ENDOCRINOL SER, P71, DOI 10.1007/978-3-319-44433-8_3
   HALLSTEN L, 1993, S AP PSYC S, P95
   Harvey SB, 2017, OCCUP ENVIRON MED, V74, P301, DOI 10.1136/oemed-2016-104015
   Haskell WL, 2007, MED SCI SPORT EXER, V39, P1423, DOI [10.1249/mss.0b013e3180616b27, 10.1161/CIRCULATIONAHA.107.185649]
   Hobfoll S. E., 2000, Handbook of organization behavior, P57, DOI DOI 10.1037/0003-066X.44.3.513
   HOBFOLL SE, 1989, AM PSYCHOL, V44, P513, DOI 10.1037/0003-066X.44.3.513
   Holmes ME, 2010, OBES REV, V11, P492, DOI 10.1111/j.1467-789X.2009.00680.x
   Huang CJ, 2013, FRONT PHYSIOL, V4, DOI 10.3389/fphys.2013.00314
   HULL EM, 1984, PSYCHOPHYSIOLOGY, V21, P353, DOI 10.1111/j.1469-8986.1984.tb02947.x
   Hwang WJ, 2014, JPN J NURS SCI, V11, P23, DOI 10.1111/j.1742-7924.2012.00226.x
   Kang MG, 2004, YONSEI MED J, V45, P838, DOI 10.3349/ymj.2004.45.5.838
   Karasek RA, 1990, Healthy work: Stress, productivity, and the reconstruction of working life
   Kinnunen M., 2006, J INDIVID DIFFER, V27, P151
   Klaperski S., 2018, Stressregulation und Sport, DOI [DOI 10.1007/9783-66249322-98, DOI 10.1007/978-3-662-49322-9_8]
   Krishnamoorthy Y, 2022, NUTR METAB CARDIOVAS, V32, P40, DOI 10.1016/j.numecd.2021.09.006
   Kuo WC, 2019, OBES REV, V20, P1651, DOI 10.1111/obr.12915
   Loerbroks A, 2015, INT J CARDIOL, V182, P390, DOI 10.1016/j.ijcard.2015.01.030
   MacCallum RC, 2002, PSYCHOL METHODS, V7, P19, DOI 10.1037//1082-989X.7.1.19
   MacKinnon DP, 2007, ANNU REV PSYCHOL, V58, P593, DOI 10.1146/annurev.psych.58.110405.085542
   Magnavita N, 2014, RADIOL MED, V119, P142, DOI 10.1007/s11547-013-0329-0
   McAuley E, 2000, Exerc Sport Sci Rev, V28, P85
   McEwen BS, 2007, PHYSIOL REV, V87, P873, DOI 10.1152/physrev.00041.2006
   Mcmurray RG, 2004, MED SCI SPORT EXER, V36, P2135
   MELAMED S, 1992, BEHAV MED, V18, P53, DOI 10.1080/08964289.1992.9935172
   Melamed S., 2006, INT J STRESS MANAGE, V13, P176, DOI DOI 10.1037/1072-5245.13.2.176
   Melamed S, 2006, PSYCHOL BULL, V132, P327, DOI 10.1037/0033-2909.132.3.327
   Miles L, 2007, NUTR BULL, V32, P314, DOI 10.1111/j.1467-3010.2007.00668.x
   Miranda PJ, 2005, AM HEART J, V149, P33, DOI 10.1016/j.ahj.2004.07.013
   Nguyen TM, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18073791
   Niedhammer I, 2021, SCAND J WORK ENV HEA, V47, P489, DOI 10.5271/sjweh.3968
   Niskanen L, 2004, HYPERTENSION, V44, P859, DOI 10.1161/01.HYP.0000146691.51307.84
   Pate RR, 2003, PEDIATR EXERC SCI, V15, P257, DOI 10.1123/pes.15.3.257
   Pérez-Martínez P, 2017, NUTR REV, V75, P307, DOI 10.1093/nutrit/nux014
   Piercy KL, 2018, CIRC-CARDIOVASC QUAL, V11, DOI 10.1161/CIRCOUTCOMES.118.005263
   Posadzki P, 2020, BMC PUBLIC HEALTH, V20, DOI 10.1186/s12889-020-09855-3
   Richardson CR, 2004, MED SCI SPORT EXER, V36, P1923, DOI 10.1249/01.MSS.0000145443.02568.7A
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Salmon P, 2001, CLIN PSYCHOL REV, V21, P33, DOI 10.1016/S0272-7358(99)00032-X
   Santos AE, 2018, AM J IND MED, V61, P911, DOI 10.1002/ajim.22910
   Schilling R, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0236526
   Schmidt B, 2015, INT J CARDIOL, V178, P24, DOI 10.1016/j.ijcard.2014.10.115
   Schultz AB, 2009, METAB SYNDR RELAT D, V7, P459, DOI 10.1089/met.2009.0008
   Shirom A., 1989, International review of industrial and organizational psychology, P25
   Shirom A, 2013, APPL PSYCHOL-HLTH WE, V5, P79, DOI 10.1111/j.1758-0854.2012.01071.x
   Shoman Y, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18179188
   Shrout PE, 2002, PSYCHOL METHODS, V7, P422, DOI 10.1037//1082-989X.7.4.422
   Siltaloppi M, 2009, WORK STRESS, V23, P330, DOI 10.1080/02678370903415572
   Sothmann M., 2006, The psychobiology of physical activity, P149
   STONE EF, 1989, J APPL PSYCHOL, V74, P3, DOI 10.1037/0021-9010.74.1.3
   Suls J, 2005, PSYCHOL BULL, V131, P260, DOI 10.1037/0033-2909.131.2.260
   Toker S., 2017, The handbook of stress and health: A guide to research and practice p, P168, DOI DOI 10.1002/9781118993811.CH10
   Toker S, 2008, DEPRESS ANXIETY, V25, P661, DOI 10.1002/da.20379
   Toker S, 2012, PSYCHOSOM MED, V74, P840, DOI 10.1097/PSY.0b013e31826c3174
   Wamala SP, 1999, DIABETES CARE, V22, P1999, DOI 10.2337/diacare.22.12.1999
   Wirtz PH, 2003, PSYCHOSOM MED, V65, P672, DOI 10.1097/01.PSY.0000062529.39901.C7
   World Health Organization, 2019, INT STAT CLASS DIS R
   Yamaguchi M, 2018, J OCCUP HEALTH, V60, P485, DOI 10.1539/joh.2017-0298-OA
   Zhang DD, 2017, METABOLISM, V75, P36, DOI 10.1016/j.metabol.2017.08.001
NR 92
TC 4
Z9 4
U1 1
U2 20
PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA
SN 1072-5245
EI 1573-3424
J9 INT J STRESS MANAGE
JI Int. J. Stress Manage.
PD FEB
PY 2023
VL 30
IS 1
BP 95
EP 107
DI 10.1037/str0000270
EA JAN 2023
PG 13
WC Psychology, Applied
WE Social Science Citation Index (SSCI)
SC Psychology
GA I0YY9
UT WOS:000906005900001
DA 2025-06-11
ER

PT J
AU Redina, OE
   Smolenskaya, SE
   Maslova, LN
   Markel, AL
AF Redina, Olga E.
   Smolenskaya, Svetlana E.
   Maslova, Larissa N.
   Markel, Arcady L.
TI The Genetic Control of Blood Pressure and Body Composition in Rats with
   Stress-Sensitive Hypertension
SO CLINICAL AND EXPERIMENTAL HYPERTENSION
LA English
DT Article
DE blood pressure; body composition; QTL; ISIAH rats; stress-induced
   arterial hypertension
ID QUANTITATIVE TRAIT LOCI; INDUCED ARTERIAL-HYPERTENSION; OXIDATIVE
   STRESS; METABOLIC SYNDROME; EMOTIONAL-STRESS; CONGENIC STRAINS;
   HEART-FAILURE; RENAL INJURY; ISIAH RATS; SALT
AB The genetic basis of the stress-sensitive arterial hypertension was investigated using the quantitative trait loci (QTL) approach. Two groups of F-2 (inherited stress-induced arterial hypertension [ISIAH] x Wistar albino Glaxo [WAG]) hybrid males of different age (3-4 months old and 6 months old) were tested for blood pressure at rest and stressed conditions and for body composition traits. Several novel loci for the traits were determined. Some loci for blood pressure and organ weight were mapped to the same genetic region in rats of different age. The dynamic change of QTL effects in two rat groups of different age might reflect the process of stress-sensitive hypertension development.
C1 [Redina, Olga E.; Smolenskaya, Svetlana E.; Maslova, Larissa N.; Markel, Arcady L.] Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk 630090, Russia.
   [Markel, Arcady L.] Novosibirsk State Univ, Novosibirsk 630090, Russia.
C3 Russian Academy of Sciences; Siberian Branch of the Russian Academy of
   Sciences; Institute of Cytology & Genetics ICG SB RAS; Novosibirsk State
   University
RP Redina, OE (corresponding author), Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, 10 Lavrentieva Ave, Novosibirsk 630090, Russia.
EM oredina@ngs.ru
RI Redina, Olga/T-1650-2017
OI Redina, Olga/0000-0003-0942-8460
FU Russian Foundation for Basic Research; Presidium Programs of Russian
   Academy of Sciences [6.15, 27.26]
FX This work was supported by the Russian Foundation for Basic Research and
   partly by Presidium Programs of Russian Academy of Sciences: "Molecular
   and Cellular Biology" (grant 6.15) and "Biodiversity" (grant 27.26).
CR Adarichev VA, 1996, GENETIKA+, V32, P1669
   Ahmadiyeh N, 2005, BEHAV GENET, V35, P189, DOI 10.1007/s10519-004-1018-5
   Ahmadiyeh N, 2003, MAMM GENOME, V14, P748, DOI 10.1007/s00335-003-2292-x
   Amaya F, 2001, NEUROENDOCRINOLOGY, V73, P185, DOI 10.1159/000054635
   Atchley WR, 2000, GENETICS, V155, P1347
   Basten C.J., 1994, Procceding of the 5th World Congress on Genetics Applied to Livestock Production: Computing Strategies and Software, P65
   Basten C J., 2004, QTL Cartographer Version 1.17
   Beck SR, 2003, BMC GENET, V4, DOI 10.1186/1471-2156-4-S1-S31
   Bergamini C, 2009, EUR J HEART FAIL, V11, P444, DOI 10.1093/eurjhf/hfp042
   Bilusic M, 2004, HYPERTENSION, V44, P695, DOI 10.1161/01.HYP.0000144542.57306.5e
   Carlborg Ö, 2003, GENOME RES, V13, P413, DOI 10.1101/gr.528003
   CHURCHILL GA, 1994, GENETICS, V138, P963
   de Cavanagh EMV, 2010, AM J HYPERTENS, V23, P1318, DOI 10.1038/ajh.2010.167
   de Souza DB, 2011, KIDNEY BLOOD PRESS R, V34, P424, DOI 10.1159/000328331
   DOHANICS J, 1990, PEPTIDES, V11, P59, DOI 10.1016/0196-9781(90)90110-Q
   FELD LG, 1977, KIDNEY INT, V12, P332, DOI 10.1038/ki.1977.120
   Garrett MR, 2006, PHYSIOL GENOMICS, V25, P39, DOI 10.1152/physiolgenomics.00150.2005
   Garrett MR, 2003, J AM SOC NEPHROL, V14, P1175, DOI 10.1097/01.ASN.0000060572.13794.58
   Gauguier D, 2005, HYPERTENSION, V45, P460, DOI 10.1161/01.HYP.0000155213.83719.7c
   Gavras I, 2012, J HYPERTENS, V30, P655, DOI 10.1097/HJH.0b013e32834f6de1
   Harshfield GA, 2009, CURR HYPERTENS REP, V11, P29, DOI 10.1007/s11906-009-0007-8
   HENRY JP, 1993, HYPERTENSION, V21, P714, DOI 10.1161/01.HYP.21.5.714
   Herrera VLM, 2006, PHYSIOL GENOMICS, V26, P172, DOI 10.1152/physiolgenomics.00285.2005
   Iwai N, 1999, CIRCULATION, V100, P1923, DOI 10.1161/01.CIR.100.18.1923
   Karlsen FM, 1997, HYPERTENSION, V30, P975, DOI 10.1161/01.HYP.30.4.975
   Kitiyakara C, 2003, J AM SOC NEPHROL, V14, P2775, DOI 10.1097/01.ASN.0000092145.90389.65
   Klöting I, 2001, BIOCHEM BIOPH RES CO, V284, P150, DOI 10.1006/bbrc.2001.4932
   Kovács P, 2000, BIOCHEM BIOPH RES CO, V269, P660, DOI 10.1006/bbrc.2000.2352
   Kovács P, 1998, MAMM GENOME, V9, P294, DOI 10.1007/s003359900751
   Kovács P, 1998, BIOCHEM MOL BIOL INT, V44, P399
   Kyrou L, 2008, HORM-INT J ENDOCRINO, V7, P287, DOI 10.14310/horm.2002.1209
   LANDER E, 1995, NAT GENET, V11, P241, DOI 10.1038/ng1195-241
   LANDER E S, 1987, Genomics, V1, P174, DOI 10.1016/0888-7543(87)90010-3
   Legare ME, 2000, GENOME RES, V10, P42
   Lin WJ, 2003, CHINESE SCI BULL, V48, P1565, DOI 10.1360/03wc0007
   López B, 2006, AM J PHYSIOL-RENAL, V290, pF1213, DOI 10.1152/ajprenal.00335.2005
   Markel AL, 2007, J ENDOCRINOL, V195, P439, DOI 10.1677/JOE-07-0254
   Markel A.L., 1999, HBK HYPERT, VVolume 19, P493
   MARKEL AL, 1992, COLLOQ INSE, V218, P405
   Morel L, 2001, P NATL ACAD SCI USA, V98, P1787, DOI 10.1073/pnas.031336098
   Moreno C, 2003, PHYSIOL GENOMICS, V15, P243, DOI 10.1152/physiolgenomics.00105.2003
   Rapp JP, 2000, PHYSIOL REV, V80, P135, DOI 10.1152/physrev.2000.80.1.135
   Redina OE, 2006, CLIN EXP PHARMACOL P, V33, P456, DOI 10.1111/j.1440-1681.2006.04387.x
   Redina OE, 2010, CLIN EXP HYPERTENS, V32, P364, DOI 10.3109/10641961003628502
   Samani NJ, 1996, HYPERTENSION, V28, P1118, DOI 10.1161/01.HYP.28.6.1118
   Sambrook J., 1989, Molecular cloning, V2
   Seda O, 2005, PHYSIOL GENOMICS, V21, P243, DOI 10.1152/physiolgenomics.00230.2004
   Shmerling M D, 2001, Morfologiia, V120, P70
   Siegel AK, 2003, ARTERIOSCL THROM VAS, V23, P1211, DOI 10.1161/01.ATV.0000079509.20542.C9
   Solberg LC, 2006, PHYSIOL GENOMICS, V27, P362, DOI 10.1152/physiolgenomics.00052.2006
   Tamashiro KLK, 2007, AM J PHYSIOL-REG I, V293, pR1864, DOI 10.1152/ajpregu.00371.2007
   Tanomura H, 2002, J VET MED SCI, V64, P45, DOI 10.1292/jvms.64.45
   TINNIKOV AA, 1984, LAB DELO, P709
   Toland EJ, 2008, J HYPERTENS, V26, P2134, DOI 10.1097/HJH.0b013e32830ef95c
   Tsutsui H, 2011, AM J PHYSIOL-HEART C, V301, pH2181, DOI 10.1152/ajpheart.00554.2011
   Ueno T, 2003, PHYSIOL RES, V52, P689, DOI 10.33549/physiolres.930000.52.689
   Ways JA, 2007, PHYSIOL GENOMICS, V29, P91, DOI 10.1152/physiolgenomics.00027.2006
   Xiao B, 2011, J HYPERTENS, V29, P257, DOI 10.1097/HJH.0b013e32834137cd
   Yagil C, 1999, HYPERTENSION, V33, P261, DOI 10.1161/01.HYP.33.1.261
   [Якобсон Г.С. Yakobson G.S.], 2007, [Сибирский научный медицинский журнал, The Siberian Scientific Medical Journal], V27, P142
NR 60
TC 15
Z9 16
U1 0
U2 8
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1064-1963
EI 1525-6006
J9 CLIN EXP HYPERTENS
JI Clin. Exp. Hypertens.
PY 2013
VL 35
IS 7
BP 484
EP 495
DI 10.3109/10641963.2012.758274
PG 12
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA 231JX
UT WOS:000325413800002
PM 23302051
DA 2025-06-11
ER

PT J
AU Han, J
   Wang, RY
   Bai, LJ
   Liu, Y
   Liao, M
   Zhang, LT
   Liu, LH
   Qi, BL
AF Han, Jing
   Wang, Ruiyun
   Bai, Lijuan
   Liu, Yun
   Liao, Man
   Zhang, Liting
   Liu, Lihua
   Qi, Benling
TI Impact of serum carotenoids on cardiovascular mortality risk in
   middle-aged and elderly adults with metabolic syndrome
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE cardiovascular mortality; carotenoids; antioxidant; metabolic syndrome;
   NHANES
ID PLASMA LYCOPENE; OXIDATIVE STRESS; BETA-CAROTENE; OLDER-ADULTS; DISEASE;
   ASSOCIATION; PREVALENCE; ATHEROSCLEROSIS; ANTIOXIDANT; CHOLESTEROL
AB Background Metabolic syndrome (MetS), characterized by abdominal adiposity, hypertension, hyperglycemia, and dyslipidemia, is associated with dysregulated immune function, elevated oxidative stress, and chronic low-grade inflammation. Aging exacerbates insulin resistance and the prevalence of MetS. Dietary antioxidants, such as carotenoids, may play a role in preventing cardiovascular disease (CVD) mortality, but evidence remains mixed, particularly among middle-aged and elderly individuals with MetS.Methods We analyzed data from 6,601 participants aged 40 years and above with MetS from the National Health and Nutrition Examination Survey (NHANES) III (1988-1994) and NHANES 2001-2006 cycles. Serum concentrations of alpha-carotene, beta-carotene, lycopene, beta-cryptoxanthin, and combined lutein/zeaxanthin were quantified. Participants were followed for a median of 16.8 years. Cox proportional-hazards models were used to assess the association between serum carotenoid concentrations and CVD mortality risk, with adjustment for potential confounders.Results During the follow-up period, 1,237 CVD deaths were identified. Analysis revealed an inverse dose-response relationship between serum lycopene levels and cardiovascular mortality risk. Compared to the lowest quartile, the multivariable-adjusted hazard ratios (95% confidence intervals) for ascending quartiles of serum lycopene were 0.84 (0.71, 1.00), 0.87 (0.74, 1.03), and 0.77 (0.61, 0.97), with a significant trend (p = 0.039). No significant associations were observed for other carotenoids.Conclusion In this prospective cohort study of 40-year-old and older individuals with MetS, we observed an inverse association between serum lycopene levels and CVD mortality risk.
C1 [Han, Jing; Wang, Ruiyun; Bai, Lijuan; Liu, Yun; Liao, Man; Zhang, Liting; Liu, Lihua; Qi, Benling] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Geriatr, Wuhan, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology
RP Liu, LH; Qi, BL (corresponding author), Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Geriatr, Wuhan, Hubei, Peoples R China.
EM huahuahbhb@163.com; qibenlingok_2015@163.com
FU National Natural Science Foundation of China10.13039/501100001809
FX The authors thank the staff and the participants of the NHANES study for
   their valuable contributions. During the writing of this work, the
   authors used OpenAI's Chatgpt 3.5 in order to check grammar, spelling
   and optimize sentences to enhance the readability of the article. After
   using this tool/service, the authors reviewed and edited the content as
   necessary and take full responsibility for the content of the
   publication.
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Assis RP, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18040332
   Awoyemi A, 2018, DIABETOL METAB SYNDR, V10, DOI 10.1186/s13098-018-0360-3
   Beddhu S, 2009, CLIN J AM SOC NEPHRO, V4, P1901, DOI 10.2215/CJN.01970309
   Bentzon JF, 2014, CIRC RES, V114, P1852, DOI 10.1161/CIRCRESAHA.114.302721
   Beydoun MA, 2019, NUTR REV, V77, P32, DOI 10.1093/nutrit/nuy044
   Bialkowska A, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12071336
   Bouayed J, 2024, BRIT J NUTR, V132, P50, DOI 10.1017/S0007114524000758
   Chang KV, 2019, DIABET METAB SYND OB, V12, P1821, DOI 10.2147/DMSO.S219649
   Chiva-Blanch G, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061696
   Duni A, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20153711
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Föhr T, 2024, INT J OBESITY, V48, P778, DOI 10.1038/s41366-024-01466-x
   Furukawa S., 2004, Journal of Clinical Investigation, V114, P1752, DOI 10.1172/JCI21625
   Gou RY, 2024, FRONT MED-LAUSANNE, V11, DOI 10.3389/fmed.2024.1380464
   Gouranton E, 2011, J NUTR BIOCHEM, V22, P642, DOI 10.1016/j.jnutbio.2010.04.016
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hennekens CH, 1996, NEW ENGL J MED, V334, P1145, DOI 10.1056/NEJM199605023341801
   Hozawa A, 2009, J HYPERTENS, V27, P237, DOI 10.1097/HJH.0b013e32832258c9
   Hu YC, 2022, FRONT MED-LAUSANNE, V9, DOI 10.3389/fmed.2022.871767
   Iribarren C, 1997, ARTERIOSCL THROM VAS, V17, P1171, DOI 10.1161/01.ATV.17.6.1171
   Jakubek P, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25147827
   Jayedi A, 2019, PUBLIC HEALTH NUTR, V22, P1872, DOI 10.1017/S1368980018003725
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Kumar R, 2017, PHARMACOGN RES, V9, P161, DOI 10.4103/0974-8490.204654
   Levey AS, 2009, ANN INTERN MED, V150, P604, DOI 10.7326/0003-4819-150-9-200905050-00006
   Lin BR, 2024, NUTR METAB CARDIOVAS, V34, P2315, DOI 10.1016/j.numecd.2024.06.001
   Martin KR, 2000, ATHEROSCLEROSIS, V150, P265, DOI 10.1016/S0021-9150(99)00375-5
   Mayne ST, 1999, J NUTR, V129, P849, DOI 10.1093/jn/129.4.849
   Mccarthy K, 2023, EXP GERONTOL, V183, DOI 10.1016/j.exger.2023.112314
   Merchant RA, 2020, DIABET METAB SYND OB, V13, P2677, DOI 10.2147/DMSO.S260544
   Müller L, 2016, CRIT REV FOOD SCI, V56, P1868, DOI 10.1080/10408398.2013.801827
   Okamura T, 2011, ATHEROSCLEROSIS, V217, P201, DOI 10.1016/j.atherosclerosis.2011.03.010
   Omenn GS, 1996, NEW ENGL J MED, V334, P1150, DOI 10.1056/NEJM199605023341802
   Przybylska S, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23041957
   Qiu ZX, 2022, DIABETES CARE, V45, P1453, DOI 10.2337/dc21-2371
   Ribeiro D, 2018, FOOD CHEM TOXICOL, V120, P681, DOI 10.1016/j.fct.2018.07.060
   Ried K, 2009, BMC COMPLEM ALTERN M, V9, DOI 10.1186/1472-6882-9-22
   Roskams T, 2003, AM J PATHOL, V163, P1301, DOI 10.1016/S0002-9440(10)63489-X
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sesso HD, 2005, AM J CLIN NUTR, V81, P990
   Sesso HD, 2004, AM J CLIN NUTR, V79, P47
   Shardell MD, 2011, NUTR RES, V31, P178, DOI 10.1016/j.nutres.2011.03.003
   Sies H, 2017, ANNU REV BIOCHEM, V86, P715, DOI 10.1146/annurev-biochem-061516-045037
   Sluijs I, 2009, J NUTR, V139, P987, DOI 10.3945/jn.108.101451
   Sugiura M, 2015, BMJ OPEN DIAB RES CA, V3, DOI 10.1136/bmjdrc-2015-000147
   Sugiura M, 2015, BRIT J NUTR, V114, P1674, DOI 10.1017/S0007114515003268
   Yu E, 2018, J AM COLL CARDIOL, V72, P914, DOI 10.1016/j.jacc.2018.02.085
   Zhang RH, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010240
   Zhu RY, 2020, PHARMACOL RES, V159, DOI 10.1016/j.phrs.2020.104966
   Zhu X, 2023, J AM HEART ASSOC, V12, DOI 10.1161/JAHA.122.027568
NR 51
TC 1
Z9 1
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD NOV 13
PY 2024
VL 11
AR 1465972
DI 10.3389/fnut.2024.1465972
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA N3D5P
UT WOS:001363186000001
PM 39606575
OA gold
DA 2025-06-11
ER

PT J
AU Robichaud, V
   Shankar, S
   Holkem, AT
   Salmieri, S
   Aguilar-Uscanga, BR
   Millette, M
   Lacroix, M
AF Robichaud, Valerie
   Shankar, Shiv
   Holkem, Augusto Tasch
   Salmieri, Stephane
   Aguilar-Uscanga, Blanca R.
   Millette, Mathieu
   Lacroix, Monique
TI Anticancer properties and prevention of metabolic syndrome by
   probiotic-enriched powdered human milk
SO FOOD BIOSCIENCE
LA English
DT Article
DE Human milk; Probiotic formulation; In vitro studies; Metabolic syndrome
ID OXIDATIVE STRESS; CANCER; APOPTOSIS; ASSOCIATION; MECHANISMS;
   COMPONENTS; CELLS
AB This work aimed to develop a novel formulation based on human milk (HM) enriched with a probiotic formulation comprised of Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R and Lactobacillus rhamnosus CLR2 and to evaluate in vitro and in vivo anticancer properties and its impact on the prevention of risk factors of metabolic syndrome (MetS). In vitro studies were conducted on Hepa-1c1c7, HT-29, and CHO-K1 cell lines to assess the antiproliferative and anticancer properties of HM and probiotics. The in vivo study was conducted with 28 male Wistar rats fed a high-fat diet (HFD). Rats were daily force-fed with HM and HM + probiotics or water for 8 weeks. Inflammation and oxidative stress were monitored through blood cytokines and kidney investigation. Body weight and blood glucose were recorded throughout the study. The results showed that HM had antiproliferative properties and caused apoptosis of intestinal tumoral cells. Quinone reductase (QR) was induced up to 1.8x in Hepa-1c1c7 cell line demonstrating chemotherapeutic potential. HM enriched with probiotics reduced weight gain by 10% while renal oxidative damages were reduced by up to 97%. Blood insulin and Plasminogen Activator Inhibitor-1 (PAI-1) levels were also significantly reduced. The study showed that HM had antiproliferative and chemopreventive properties on cancer cell lines. The in vivo experiment suggests that the development of a formulation based on HM powder enriched with probiotics could be used to modulate the rate of inflammation and oxidative damage to tissues, thus reducing the risk of obesity-related diseases.
C1 [Robichaud, Valerie; Shankar, Shiv; Holkem, Augusto Tasch; Salmieri, Stephane; Aguilar-Uscanga, Blanca R.; Millette, Mathieu; Lacroix, Monique] Inst Nutr & Funct Foods INAF, MAPAQ Res Chair Food Safety & Qual, INRS Armand Frappier Hlth Biotechnol Res Ctr, Canadian Irradiat Ctr CIC,Res Labs Sci Appl Food R, 531 Prairies Blvd, Laval, PQ H7V 1B7, Canada.
   [Holkem, Augusto Tasch] Univ Sao Paulo, Fac Zootecnia & Engn Alimentos, Ave Duque Caxias Norte 225, BR-13635900 Pirassununga, SP, Brazil.
   [Aguilar-Uscanga, Blanca R.] Univ Guadalajara, Ctr Univ Ciencias Exactas & Ingn, Blvd Marcelino Garcia Barragan 1421, Guadalajara 44420, Jalisco, Mexico.
   [Millette, Mathieu] Kerry Co, Preclin Res Div, Bio K, 495 Armand Frappier Blvd, Laval, PQ H7V 4B3, Canada.
C3 Laval University; Universidade de Sao Paulo; Universidad de Guadalajara
RP Lacroix, M (corresponding author), Inst Nutr & Funct Foods INAF, MAPAQ Res Chair Food Safety & Qual, INRS Armand Frappier Hlth Biotechnol Res Ctr, Canadian Irradiat Ctr CIC,Res Labs Sci Appl Food R, 531 Prairies Blvd, Laval, PQ H7V 1B7, Canada.
EM monique.lacroix@inrs.ca
RI Holkem, Augusto/AAL-6257-2021
OI Millette, Mathieu/0000-0002-9134-3249
FU Ministere des Relations internationales et de la Francophonie (MRIF) of
   Quebec [30400201]; Ministere de l'Economie, de la Science et de
   l'Innovation (MESI) of Quebec [PSR-SIIRI-984]; Research
   Foundation-Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [15/19375-0, 18/05315-3]; NSERC
FX Hema-Quebec and the Human Milk Bank of Hospital Civil de Guadalajara
   (Fray Antonio Alcade neonatal intensive care unit, Jalisco, Mexico) are
   sincerely acknowledged for providing human milk. This research was
   supported by the Ministere des Relations internationales et de la
   Francophonie (MRIF) of Quebec (XVIth Quebec-Mexico Working group
   2017-2019 #30400201) , and the Ministere de l'Economie, de la Science et
   de l'Innovation (MESI) of Quebec (PSR-SIIRI-984) . The authors also
   thank the Sao Paulo Research Foundation-Fundacao de Amparo a Pesquisa do
   Estado de Sao Paulo (FAPESP) for the scholarship in Brazil (Process
   #15/19375-0) and scholarship abroad (Process #18/05315-3) awarded to
   A.T. Holkem, as well as the NSERC for the scholarship awarded to V.
   Robichaud.
CR Aceti A, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/7397659
   Agostoni C, 2013, EUR J INTERN MED, V24, P5, DOI 10.1016/j.ejim.2012.08.011
   Alessi MC, 2006, ARTERIOSCL THROM VAS, V26, P2200, DOI 10.1161/01.ATV.0000242905.41404.68
   Aluwong T, 2013, ANTIOXIDANTS-BASEL, V2, P326, DOI 10.3390/antiox2040326
   Ballard O, 2013, PEDIATR CLIN N AM, V60, P49, DOI 10.1016/j.pcl.2012.10.002
   Bergmann H, 2014, BRIT J NUTR, V112, P1119, DOI 10.1017/S0007114514001949
   Bode L, 2009, NUTR REV, V67, pS183, DOI 10.1111/j.1753-4887.2009.00239.x
   Boudry G, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.629740
   Chen C, 2015, APPL ENVIRON MICROB, V81, P7697, DOI 10.1128/AEM.02426-15
   Ejtahed HS, 2012, NUTRITION, V28, P539, DOI 10.1016/j.nut.2011.08.013
   Festi D, 2014, WORLD J GASTROENTERO, V20, P16079, DOI 10.3748/wjg.v20.i43.16079
   Fortin O., 2017, Journal of Nutraceuticals and Food Science, V2, P3
   Francisqueti FV, 2017, J NUTR SCI, V6, DOI 10.1017/jns.2017.42
   Friedman Jeffrey M., 2011, Keio Journal of Medicine, V60, P1, DOI 10.2302/kjm.60.1
   Glorieux C, 2017, BIOL CHEM, V398, P1095, DOI 10.1515/hsz-2017-0131
   Guiteras R, 2016, CLIN KIDNEY J, V9, P765, DOI 10.1093/ckj/sfw096
   Han F, 2021, INT J BIOL SCI, V17, P487, DOI 10.7150/ijbs.52452
   Hill C, 2014, NAT REV GASTRO HEPAT, V11, P506, DOI 10.1038/nrgastro.2014.66
   Jaiswal L, 2015, PROCESS BIOCHEM, V50, P2035, DOI 10.1016/j.procbio.2015.09.016
   Kedare SB, 2011, J FOOD SCI TECH MYS, V48, P412, DOI 10.1007/s13197-011-0251-1
   Kirlin WG, 1999, J NUTR, V129, P1827, DOI 10.1093/jn/129.10.1827
   Kouvari M, 2022, NUTRIENTS, V14, DOI 10.3390/nu14020333
   Krishnankutty Roopesh, 2018, Asian Pac J Cancer Prev, V19, P3501, DOI 10.31557/APJCP.2018.19.12.3501
   Lalan S, 2018, J PEDIATR-US, V202, P163, DOI 10.1016/j.jpeds.2018.06.007
   LEVINE RL, 1990, METHOD ENZYMOL, V186, P464
   Marcuzzi A, 2013, J HUM LACT, V29, P26, DOI 10.1177/0890334412466958
   Marseglia L, 2015, INT J MOL SCI, V16, P378, DOI 10.3390/ijms16010378
   Mérino D, 2007, EXPERT OPIN THER TAR, V11, P1299, DOI 10.1517/14728222.11.10.1299
   Moghadam AR, 2015, BMC COMPLEM ALTERN M, V15, DOI 10.1186/s12906-015-0773-6
   Mohammadi AA, 2015, INT J PREVENTIVE MED, V6, DOI 10.4103/2008-7802.164146
   Nagy C, 2018, JOVE-J VIS EXP, DOI 10.3791/56672
   Noeman SA, 2011, DIABETOL METAB SYNDR, V3, DOI 10.1186/1758-5996-3-17
   Oh ET, 2015, BMB REP, V48, P609, DOI 10.5483/BMBRep.2015.48.11.190
   Onyeanusi B. I., 2009, Pakistan Journal of Nutrition, V8, P1040
   Pellegrino D, 2016, Diseases, V4
   Peterson RG, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/487816
   Principi N, 2018, J INFECTION, V76, P111, DOI 10.1016/j.jinf.2017.12.013
   Ramalho JB, 2019, NUTRIENTS, V11, DOI 10.3390/nu11040901
   Richter RJ, 1999, PHARMACOGENETICS, V9, P745, DOI 10.1097/01213011-199912000-00009
   Sánchez-Hernández S, 2021, FOOD RES INT, V141, DOI 10.1016/j.foodres.2021.110149
   Seki RP, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2019-031557
   Sengul E, 2019, ASIAN PAC J TROP BIO, V9, P116, DOI 10.4103/2221-1691.254605
   Steck SE, 2020, NAT REV CANCER, V20, P125, DOI 10.1038/s41568-019-0227-4
   Sun J, 2016, BRIT J NUTR, V115, P1167, DOI 10.1017/S0007114516000076
   Svanborg C, 2003, ADV CANCER RES, V88, P1
   Thongaram T, 2017, J DAIRY SCI, V100, P7825, DOI 10.3168/jds.2017-12753
   Trinchese G, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00032
   Verduci E, 2014, NUTRIENTS, V6, P1711, DOI 10.3390/nu6041711
   Winzell MS, 2004, DIABETES, V53, pS215, DOI 10.2337/diabetes.53.suppl_3.S215
   Wolf D., 1990, Clin Methods Hist Phys Lab Exam, P478
   Zhou DD, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/6627355
NR 51
TC 0
Z9 0
U1 4
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-4292
EI 2212-4306
J9 FOOD BIOSCI
JI Food Biosci.
PD DEC
PY 2024
VL 62
AR 105354
DI 10.1016/j.fbio.2024.105354
EA OCT 2024
PG 9
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA K8T2I
UT WOS:001346559200001
DA 2025-06-11
ER

PT J
AU Maruyama-Fumoto, K
   McGuire, JJ
   Fairlie, DP
   Shinozuka, K
   Kagota, S
AF Maruyama-Fumoto, Kana
   McGuire, John J.
   Fairlie, David P.
   Shinozuka, Kazumasa
   Kagota, Satomi
TI Activation of protease-activated receptor 2 is associated with blood
   pressure regulation and proteinuria reduction in metabolic syndrome
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article
DE metabolic syndrome; protease&#8208; activated receptor&#8208; 2;
   proteinuria; renal artery; vasorelaxation
ID DIET-INDUCED OBESITY; ANIMAL-MODEL; SHRSP.Z-LEPR(FA)/IZMDMCR RATS;
   CORONARY VASODILATION; STRESS; INFLAMMATION; TELMISARTAN; ANTAGONISM;
   MECHANISMS; EXPRESSION
AB Metabolic syndrome (MetS) increases the risk of kidney disease. In SHRSP.Z-Lepr(fa)/IzmDmcr (SHRSP.ZF) rats with MetS, protease-activated receptor 2 (PAR2)-mediated vasorelaxation is preserved in the aorta at 20 weeks of age (weeks) via enhancement of nitric oxide production but impaired at 30 weeks by oxidative stress. However, impairment of PAR2-mediated vasorelaxation of renal arteries and its possible implications for kidney disease are unclear. We used organ baths to assess PAR2-mediated vasorelaxation of isolated renal arteries, colorimetric methods to measure urinary protein levels as an index of renal function, and western blot to determine expression of PAR2 and nephrin proteins in the kidneys of SHRSP.ZF rats at 10, 20, and 30 weeks. We assessed renal arteries and kidney function for effects of orally administered GB88, a pathway-dependent PAR2 antagonist, from 10 to 18 weeks, and azilsartan, an angiotensin II type 1 receptor blocker, from 13 to 23 weeks. PAR2-mediated vasorelaxation was slightly lower at 20 weeks and attenuated significantly at 30 weeks compared with those at 10 weeks. Urinary protein levels were increased at 20 and 30 weeks. Decreased protein expression of PAR2 and nephrin in the kidney were observed at 30 weeks. Administration of GB88 increased blood pressure (BP) and proteinuria. Azilsartan reduced the high BP and the impaired PAR2-mediated vasorelaxation, but did not restore the increase in urinary protein levels and decreased PAR2 and nephrin protein expression in the kidney. PAR2 activation in the kidney may be associated with maintenance of BP and urinary protein excretion in MetS.
C1 [Maruyama-Fumoto, Kana; Shinozuka, Kazumasa; Kagota, Satomi] Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol 2, 11-68 Koshien Kyubancho, Nishinomiya, Hyogo 6638179, Japan.
   [McGuire, John J.] Western Univ, Schulich Sch Med & Dent, Dept Med Biophys, London, ON, Canada.
   [Fairlie, David P.] Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.
C3 Mukogawa Women's University; Western University (University of Western
   Ontario); University of Queensland
RP Kagota, S (corresponding author), Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol 2, 11-68 Koshien Kyubancho, Nishinomiya, Hyogo 6638179, Japan.
EM skagota@mukogawa-u.ac.jp
RI Fairlie, David/F-8865-2014
OI McGuire, John/0000-0003-0302-3884; Kagota, Satomi/0000-0003-2044-5552
FU NHMRC [1117017]; National Health and Medical Research Council of
   Australia [1117017] Funding Source: NHMRC
FX NHMRC, Grant/Award Number: a Senior Principal Research Fellowship
   (1117017)
CR Abdelsaid M, 2014, TRANSL RES, V164, P424, DOI 10.1016/j.trsl.2014.06.003
   Emilsson K, 1997, J VASC RES, V34, P267, DOI 10.1159/000159233
   Faul C, 2007, TRENDS CELL BIOL, V17, P428, DOI 10.1016/j.tcb.2007.06.006
   Hiraoka-Yamamoto J, 2004, CLIN EXP PHARMACOL P, V31, P107, DOI 10.1111/j.1440-1681.2004.04121.x
   Howitt L, 2014, VASC PHARMACOL, V61, P10, DOI 10.1016/j.vph.2014.02.002
   Hughes KH, 2013, CAN J PHYSIOL PHARM, V91, P295, DOI 10.1139/cjpp-2012-0266
   Jiang YH, 2017, ACS CHEM BIOL, V12, P1217, DOI 10.1021/acschembio.6b01088
   Jin G, 2005, J CEREBR BLOOD F MET, V25, P302, DOI 10.1038/sj.jcbfm.9600021
   Joyce T, 2018, EUR J PHARMACOL, V818, P554, DOI 10.1016/j.ejphar.2017.11.032
   Kagota S, 2016, BIOMED RES INT, V2016, DOI 10.1155/2016/3130496
   Kagota S, 2014, VASC PHARMACOL, V63, P46, DOI 10.1016/j.vph.2014.06.005
   Kagota S, 2013, MICROVASC RES, V88, P70, DOI 10.1016/j.mvr.2013.04.001
   Kagota S, 2011, BRIT J PHARMACOL, V164, P358, DOI 10.1111/j.1476-5381.2011.01356.x
   Kagota S, 2011, CAN J PHYSIOL PHARM, V89, P355, DOI [10.1139/Y11-029, 10.1139/y11-029]
   Kagota S, 2010, CLIN EXP PHARMACOL P, V37, P1035, DOI 10.1111/j.1440-1681.2010.05432.x
   Kagota S, 2009, J PHARMACOL SCI, V109, P556, DOI 10.1254/jphs.08273FP
   Kawachi H, 2020, CLIN EXP NEPHROL, V24, P193, DOI 10.1007/s10157-020-01854-3
   Khan MAH, 2014, AM J HYPERTENS, V27, P1087, DOI 10.1093/ajh/hpu016
   Kubota Y, 2006, BIOL PHARM BULL, V29, P1756, DOI 10.1248/bpb.29.1756
   Lim JX, 2013, FASEB J, V27, P4757, DOI 10.1096/fj.13-232702
   Lohman RJ, 2012, FASEB J, V26, P2877, DOI 10.1096/fj.11-201004
   Lohman RJ, 2012, J PHARMACOL EXP THER, V340, P256, DOI 10.1124/jpet.111.187062
   Ma FY, 2019, NEPHROLOGY, V24, P983, DOI 10.1111/nep.13635
   Maruyama K, 2017, CAN J PHYSIOL PHARM, V95, P356, DOI 10.1139/cjpp-2016-0298
   Maruyama K, 2015, J VASC RES, V52, P232, DOI 10.1159/000442415
   Matsumoto T, 2009, PEPTIDES, V30, P1729, DOI 10.1016/j.peptides.2009.06.014
   McGuire John J., 2008, BMC Physiology, V8, P20, DOI 10.1186/1472-6793-8-20
   McLean PG, 2002, CIRC RES, V90, P465, DOI 10.1161/hh0402.105372
   Morla L, 2013, J BIOL CHEM, V288, P10124, DOI 10.1074/jbc.M112.446393
   Nikolopoulou A, 2012, EXPERT REV CARDIOVAS, V10, P933, DOI [10.1586/erc.12.74, 10.1586/ERC.12.74]
   Oe Y, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-39914-8
   Oe Y, 2016, ARTERIOSCL THROM VAS, V36, P1525, DOI 10.1161/ATVBAHA.116.307883
   Ojima M, 2011, J PHARMACOL EXP THER, V336, P801, DOI 10.1124/jpet.110.176636
   Palygin O, 2016, AM J PHYSIOL-RENAL, V311, pF1140, DOI 10.1152/ajprenal.00460.2016
   Suen JY, 2014, BRIT J PHARMACOL, V171, P4112, DOI 10.1111/bph.12757
   Suen JY, 2012, BRIT J PHARMACOL, V165, P1413, DOI 10.1111/j.1476-5381.2011.01610.x
   Sugiyama F, 2013, CLIN EXP NEPHROL, V17, P515, DOI 10.1007/s10157-012-0759-3
   Tada Y, 2010, BIOL PHARM BULL, V33, P1971, DOI 10.1248/bpb.33.1971
   Vesey DA, 2007, NEPHROLOGY, V12, P36, DOI 10.1111/j.1440-1797.2006.00746.x
   Wang YJ, 2017, CELL PHYSIOL BIOCHEM, V41, P1147, DOI 10.1159/000464121
   Yoshitomi H, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-13
   Yu SMW, 2018, FRONT MED-LAUSANNE, V5, DOI 10.3389/fmed.2018.00221
NR 42
TC 2
Z9 3
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1870
EI 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD FEB
PY 2021
VL 48
IS 2
BP 211
EP 220
DI 10.1111/1440-1681.13431
EA NOV 2020
PG 10
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA PO4NO
UT WOS:000590815300001
PM 33124085
DA 2025-06-11
ER

PT S
AU Banhegyi, G
   Baumeister, P
   Benedetti, A
   Dong, D
   Fu, Y
   Lee, AS
   Li, J
   Mao, C
   Margittai, É
   Ni, M
   Paschen, W
   Piccirella, S
   Senesi, S
   Sitia, R
   Wang, M
   Yang, W
AF Banhegyi, Gabor
   Baumeister, Peter
   Benedetti, Angelo
   Dong, Dezheng
   Fu, Yong
   Lee, Amy S.
   Li, Jianze
   Mao, Changhui
   Margittai, Eva
   Ni, Min
   Paschen, Wulf
   Piccirella, Simona
   Senesi, Silvia
   Sitia, Roberto
   Wang, Miao
   Yang, Wei
BE Csermely, P
   Korcsmaros, T
   Sulyok, K
TI Endoplasmic reticulum stress
SO STRESS RESPONSES IN BIOLOGY AND MEDICINE: STRESS OF LIFE IN MOLECULES,
   CELLS, ORGANISMS, AND PSYCHOSOCIAL COMMUNITIES
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 2nd World Conference on Stress
CY AUG 23-26, 2007
CL Budapest, HUNGARY
DE endoplasmic reticulum; stress; GRP78; cerebral ischemia; plasma cell;
   glucocorticoids; metabolic syndrome; obesity
ID UNFOLDED PROTEIN RESPONSE; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1;
   MICROSOMAL GLUCOSE-6-PHOSPHATE TRANSLOCASE; TRANSIENT CEREBRAL-ISCHEMIA;
   GLUCOSE-REGULATED PROTEINS; MARINESCO-SJOGREN-SYNDROME; NEURONAL
   CELL-DEATH; HEXOSE-6-PHOSPHATE DEHYDROGENASE; TUMOR PROGRESSION; CALCIUM
   HOMEOSTASIS
AB Stress is the imbalance of homeostasis, which can be sensed even at the subcellular level. The stress-sensing capability of various organelles including the endoplasmic reticulum (ER) has been described. It has become evident that acute or prolonged ER stress plays an important role in many human diseases; especially those involving organs/tissues specialized in protein secretion. This article summarizes the emerging role of ER stress in diverse human pathophysiological conditions such as carcinogenesis and tumor progression, cerebral ischemia, plasma cell maturation and apoptosis, obesity, insulin resistance, and type 2 diabetes. Certain components of the ER stress response machinery are identified as biomarkers of the diseases or as possible targets for therapeutic intervention.
C1 Semmelweis Univ, Inst Med Chem Mol Biol & Pathobiochem, H-1088 Budapest, Hungary.
   Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Keck Sch Med, Los Angeles, CA 90033 USA.
   Univ So Calif, Dept Biochem & Mol Biol, Los Angeles, CA USA.
   Univ Siena, Dept Pathophysiol Expt Med & Publ Hlth, I-53100 Siena, Italy.
   Duke Univ, Med Ctr, Dept Anesthesiol, Multidisciplinary Neuroprotect Labs, Durham, NC 27710 USA.
   Duke Univ, Med Ctr, Dept Neurobiol, Multidisciplinary Neuroprotect Labs, Durham, NC 27710 USA.
   Univ Vita Salute San Raffaele, DiBiT Ist Sci San Raffaele, Milan, Italy.
C3 Semmelweis University; University of Southern California; University of
   Southern California; University of Siena; Duke University; Duke
   University; Vita-Salute San Raffaele University
RP Banhegyi, G (corresponding author), Semmelweis Univ, Inst Med Chem Mol Biol & Pathobiochem, Puskin Utca 9, H-1088 Budapest, Hungary.
EM banhegyi@puskin.sote.hu
RI Ni, Min/KIL-1395-2024; Sitia, Roberto/AAB-5005-2019; Bánhegyi,
   Gábor/A-1476-2014; Yang, Wei/C-6476-2008; Fu, Yong/A-4247-2012
OI Ni, Min/0000-0002-4587-1622; Fu, Yong/0000-0002-8423-8803; Sitia,
   Roberto/0000-0001-7086-4152; Lee, Amy/0000-0002-0378-5443
CR AGARWAL AK, 1989, J BIOL CHEM, V264, P18939
   Anttonen AK, 2005, NAT GENET, V37, P1309, DOI 10.1038/ng1677
   Bánhegyi G, 2004, J BIOL CHEM, V279, P27017, DOI 10.1074/jbc.M404159200
   Belkaid A, 2006, CANCER CELL INT, V6, DOI 10.1186/1475-2867-6-7
   Belkaid A, 2006, FEBS LETT, V580, P3746, DOI 10.1016/j.febslet.2006.05.071
   Benham AM, 2006, ANTIOXID REDOX SIGN, V8, P271, DOI 10.1089/ars.2006.8.271
   BUBLITZ C, 1987, BIOCHEM J, V245, P263, DOI 10.1042/bj2450263
   BURDA J, 1994, BIOCHEM J, V302, P335, DOI 10.1042/bj3020335
   Cenci S, 2006, EMBO J, V25, P1104, DOI 10.1038/sj.emboj.7601009
   DeGracia DJ, 2004, J NEUROCHEM, V91, P1, DOI 10.1111/j.1471-4159.2004.02703.x
   Doutheil J, 2000, CELL CALCIUM, V27, P107, DOI 10.1054/ceca.1999.0099
   Feldman DE, 2005, MOL CANCER RES, V3, P597, DOI 10.1158/1541-7786.MCR-05-0221
   Fu Y, 2006, CANCER BIOL THER, V5, P741, DOI 10.4161/cbt.5.7.2970
   Gross E, 2006, P NATL ACAD SCI USA, V103, P299, DOI 10.1073/pnas.0506448103
   Hayashi T, 2003, J CEREBR BLOOD F MET, V23, P1117, DOI 10.1097/01.WCB.0000089600.87125.AD
   Hayashi T, 2003, J CEREBR BLOOD F MET, V23, P949, DOI 10.1097/01.WCB.0000077641.41248.EA
   Haynes CM, 2004, MOL CELL, V15, P767, DOI 10.1016/j.molcel.2004.08.025
   Hendershot LM, 2004, MT SINAI J MED, V71, P289
   Hewitt KN, 2005, ENDOCRINOLOGY, V146, P2539, DOI 10.1210/en.2005-0117
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Jamora C, 1996, P NATL ACAD SCI USA, V93, P7690, DOI 10.1073/pnas.93.15.7690
   Kaufman RJ, 1999, GENE DEV, V13, P1211, DOI 10.1101/gad.13.10.1211
   Kohno K, 1997, NEUROSCI LETT, V224, P17, DOI 10.1016/S0304-3940(97)13459-0
   Koumenis C, 2006, CURR MOL MED, V6, P55, DOI 10.2174/156652406775574604
   Kuijpers TW, 2002, EUR J PEDIATR, V161, pS75, DOI 10.1007/s00431-002-1009-6
   Kumar R, 2003, J CEREBR BLOOD F MET, V23, P462, DOI 10.1097/01.WCB.0000056064.25434.CA
   Kumar R, 2001, J NEUROCHEM, V77, P1418, DOI 10.1046/j.1471-4159.2001.00387.x
   Lavery GG, 2006, J BIOL CHEM, V281, P6546, DOI 10.1074/jbc.M512635200
   Lee AS, 2007, CANCER RES, V67, P3496, DOI 10.1158/0008-5472.CAN-07-0325
   Lee AS, 2005, METHODS, V35, P373, DOI 10.1016/j.ymeth.2004.10.010
   Lee AS, 2001, TRENDS BIOCHEM SCI, V26, P504, DOI 10.1016/S0968-0004(01)01908-9
   Lee E, 2006, CANCER RES, V66, P7849, DOI 10.1158/0008-5472.CAN-06-1660
   Leuzzi R, 2003, BLOOD, V101, P2381, DOI 10.1182/blood-2002-08-2576
   Li JZ, 2006, CURR MOL MED, V6, P45, DOI 10.2174/156652406775574523
   Luo SZ, 2006, MOL CELL BIOL, V26, P5688, DOI 10.1128/MCB.00779-06
   Ma YJ, 2003, NAT IMMUNOL, V4, P310, DOI 10.1038/ni0403-310
   Mao CH, 2006, J BIOL CHEM, V281, P8877, DOI 10.1074/jbc.M505784200
   Mao CH, 2004, NAT MED, V10, P1013, DOI 10.1038/nm1004-1013
   Marciniak SJ, 2006, PHYSIOL REV, V86, P1133, DOI 10.1152/physrev.00015.2006
   Massa SM, 1996, CEREBROVAS BRAIN MET, V8, P95
   Nakatani Y, 2005, J BIOL CHEM, V280, P847, DOI 10.1074/jbc.M411860200
   Novoa I, 2003, EMBO J, V22, P1180, DOI 10.1093/emboj/cdg112
   Odermatt A, 2006, MOL CELL ENDOCRINOL, V248, P15, DOI 10.1016/j.mce.2005.11.040
   Ozawa K, 2005, DIABETES, V54, P657, DOI 10.2337/diabetes.54.3.657
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   OZOLS J, 1995, J BIOL CHEM, V270, P2305, DOI 10.1074/jbc.270.5.2305
   Paschen W, 2005, PHARMACOL THERAPEUT, V108, P362, DOI 10.1016/j.pharmthera.2005.05.008
   Paschen W, 2004, J NEUROCHEM, V90, P694, DOI 10.1111/j.1471-4159.2004.02555.x
   Paschen W, 2003, J CEREBR BLOOD F MET, V23, P449, DOI 10.1097/01.WCB.0000054216.21675.AC
   Paschen W, 1999, J CEREBR BLOOD F MET, V19, P1, DOI 10.1097/00004647-199901000-00001
   Piccirella S, 2006, J BIOL CHEM, V281, P4671, DOI 10.1074/jbc.M509406200
   Pootrakul L, 2006, CLIN CANCER RES, V12, P5987, DOI 10.1158/1078-0432.CCR-06-0133
   Ranganathan AC, 2006, CANCER RES, V66, P1702, DOI 10.1158/0008-5472.CAN-05-3092
   Rutkowski DT, 2004, TRENDS CELL BIOL, V14, P20, DOI 10.1016/j.tcb.2003.11.001
   SELYE H, 1950, BRIT MED J, V1, P1383, DOI 10.1136/bmj.1.4667.1383
   Senderek J, 2005, NAT GENET, V37, P1312, DOI 10.1038/ng1678
   Sitia R, 2003, NATURE, V426, P891, DOI 10.1038/nature02262
   Szegezdi E, 2006, EMBO REP, V7, P880, DOI 10.1038/sj.embor.7400779
   van Anken E, 2003, IMMUNITY, V18, P243, DOI 10.1016/S1074-7613(03)00024-4
   Wu J, 2006, CELL DEATH DIFFER, V13, P374, DOI 10.1038/sj.cdd.4401840
   Yu ZF, 1999, EXP NEUROL, V155, P302, DOI 10.1006/exnr.1998.7002
   Zhao LH, 2005, NAT GENET, V37, P974, DOI 10.1038/ng1620
NR 62
TC 146
Z9 157
U1 2
U2 45
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA
SN 0077-8923
BN 978-1-57331-675-0
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2007
VL 1113
BP 58
EP 71
DI 10.1196/annals.1391.007
PG 14
WC Psychology, Biological; Behavioral Sciences; Biochemistry & Molecular
   Biology; Immunology; Multidisciplinary Sciences; Psychology, Social
WE Conference Proceedings Citation Index - Science (CPCI-S); Conference Proceedings Citation Index - Social Science &amp; Humanities (CPCI-SSH); Science Citation Index Expanded (SCI-EXPANDED)
SC Psychology; Behavioral Sciences; Biochemistry & Molecular Biology;
   Immunology; Science & Technology - Other Topics
GA BGX56
UT WOS:000251158200006
PM 17483206
DA 2025-06-11
ER

PT J
AU Denisa, M
   Daniela, G
   Cristian, P
   Cimponeriu, D
   Maria, V
   Danciulescu, R
   Niculina, M
AF Denisa, Margina
   Daniela, Gradinaru
   Cristian, Panaite
   Cimponeriu, Danut
   Maria, Vladica
   Danciulescu, Ruxandra
   Niculina, Mitrea
TI The association of adipose tissue markers for redox imbalance and the
   cardio-vascular risk in obese patients
SO HEALTHMED
LA English
DT Article
DE lipid peroxidation; redox stress; obesity; cardio-vascular risk
ID METABOLIC SYNDROME; OXIDATIVE STRESS; ADIPONECTIN; DEFICIENCY
AB Introduction: Ectopic accumulation of lipids in peripheral tissues at obese patients, leads to lipotoxicity, process that contributes to the pathophysiology of cardio-vascular complications of obesity. The aim of the study was to establish the potential link between the markers used for the evaluation of the cardio-vascular risk measured at systemic level and the redox status assessed as the susceptibility of the white adipose tissue isolated through biopsy, to induced lipid peroxidation.
   Patients and methods: 15 patients with central obesity were selected; fasting blood samples were drawn for the biochemical evaluation. White adipose tissue was harvested from all the patients and homogenated in NaOH 0.015M, at 10% concentration. The tissue susceptibility to lipid peroxidation was non-enzymatically induced by incubation in a solution mixture with FeSO(4) and ascorbic acid in a 1:10 molar ratio; lipid peroxidation products were evaluated as TBARS.
   Results: The adipose tissue susceptibility to lipid peroxidation correlated significantly with the TC level and with the LDL level. Patients with impaired lipid profile were characterised by a significantly higher susceptibility of the adipose tissue to lipid peroxidation (p=0.036 compared to normolipidemic ones), associated with the decrease of the adiponectin level.
   Conclusion: The association of dyslipidemia with obesity is based on accelerated redox and inflammatory phenomena, localized at the adipose tissue level and represents probably the intermediate step before the constellation of risk factors that defines the metabolic syndrome. This pathological core (dyslipidemia and obesity) leads to a general metabolic imbalance, similar to that of metabolic syndrome patients. A better understanding of the molecular mechanisms that are activated in obesity will help identify new drug targets for its treatment.
C1 [Denisa, Margina; Daniela, Gradinaru; Niculina, Mitrea] Carol Davila Univ Med & Pharm, Fac Pharm, Dept Biochem, Bucharest, Romania.
   [Cristian, Panaite; Cimponeriu, Danut; Maria, Vladica; Danciulescu, Ruxandra] N Paulescu Natl Inst Diabet, Bucharest, Romania.
C3 Carol Davila University of Medicine & Pharmacy
RP Denisa, M (corresponding author), Carol Davila Univ Med & Pharm, Fac Pharm, Dept Biochem, Bucharest, Romania.
EM denisa.margina@gmail.com
RI Cimponeriu, Danut/AAT-4687-2021; Margina, Denisa/J-7312-2013
OI Margina, Denisa/0000-0003-3289-147X
FU National Agency for Scientific Research [41-067/2007 PN 2]
FX The work was supported by grant 41-067/2007 PN 2 of the National Agency
   for Scientific Research.
CR Arita Y, 1999, BIOCHEM BIOPH RES CO, V257, P79, DOI 10.1006/bbrc.1999.0255
   Azzi A, 2004, FEBS LETT, V558, P3, DOI 10.1016/S0014-5793(03)01526-6
   Chen H, 2003, J BIOL CHEM, V278, P45021, DOI 10.1074/jbc.M307878200
   Fulop T, 2006, PATHOL BIOL, V54, P375, DOI 10.1016/j.patbio.2006.07.002
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Galic S, 2010, MOL CELL ENDOCRINOL, V316, P129, DOI 10.1016/j.mce.2009.08.018
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Jiao P, 2008, DIABET METAB SYND OB, V1, P25
   Kadowaki T, 2006, J CLIN INVEST, V116, P1784, DOI 10.1172/JCI29126
   Karastergiou K, 2010, MOL CELL ENDOCRINOL, V318, P69, DOI 10.1016/j.mce.2009.11.011
   de Morentin PBM, 2010, BBA-MOL CELL BIOL L, V1801, P350, DOI 10.1016/j.bbalip.2009.09.016
   Matsuzawa Y, 2006, NAT CLIN PRACT CARD, V3, P35, DOI 10.1038/ncpcardio0380
   Orzano AJ, 2004, J AM BOARD FAM PRACT, V17, P359, DOI 10.3122/jabfm.17.5.359
   Ouedraogo R, 2007, J CLIN INVEST, V117, P1718, DOI 10.1172/JCI29623
   Qi Y, 2006, DIABETES, V55, P3083, DOI 10.2337/db05-0615
   Strissel KJ, 2007, DIABETES, V56, P2910, DOI 10.2337/db07-0767
NR 16
TC 7
Z9 7
U1 0
U2 2
PU DRUNPP-SARAJEVO
PI SARAJEVO
PA BOLNICKA BB, SARAJEVO, 71000, BOSNIA & HERCEG
SN 1840-2291
J9 HEALTHMED
JI HealthMED
PY 2011
VL 5
IS 1
BP 194
EP 199
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 727RT
UT WOS:000287819600026
DA 2025-06-11
ER

PT J
AU Spalm, FHP
   Sánchez, MLC
   Furland, NE
   Vallés, AS
AF Spalm, Facundo H. Prado H.
   Sanchez, Marie L. Cuervo
   Furland, Natalia E.
   Valles, Ana S.
TI Lipid peroxidation and neuroinflammation: A possible link between
   maternal fructose intake and delay of acquisition of neonatal reflexes
   in Wistar female rats
SO DEVELOPMENTAL NEUROBIOLOGY
LA English
DT Article
DE fructose; lipid peroxidation; metabolic syndrome; neurodevelopment;
   neuroinflammation; offspring
ID HIGH-FAT DIET; METABOLIC SYNDROME; OXIDATIVE STRESS; OBESITY;
   CONSUMPTION; BRAIN; INFLAMMATION; CHILDREN; FETAL; HYPERTENSION
AB Fructose is a common sweetener found in the daily diet supplemented to many processed and ultra-processed foods and beverages. Consumption of fructose-sweetened beverages has drastically increased in the last decades and is widely associated with metabolic disease, systemic pro-inflammatory status, and adverse transgenerational effects. To date, the impact of maternal fructose intake in brain function of the offspring is less explored. Therefore, the aim of this study was first, to investigate adverse effects in developmental milestones of the progeny of mothers with metabolic syndrome (MetS), induced by ad libitum consumption of a 20% fructose solution, and second to identify possible molecular changes in the nervous system of the newborns associated with maternal fructose intake. Wistar rats were randomly separated into two groups with access to water or fructose (20% w/v in water) for 10 weeks. After MetS was confirmed, dams were mated with control males and continued drinking water or fructose solution during gestation. At postnatal day (PN) 1, a subgroup of offspring of each sex was sacrificed and brains were dissected for oxidative stress and inflammatory status analysis. Changes in the developmental milestones due to maternal fructose consumption were studied (PN3-PN21) in another subgroup of offspring. Sexually dimorphic effects were found on the progeny's acquisition of neurodevelopmental milestones, in brain lipid peroxidation, neuroinflammation, and antioxidative defensive response. Our results suggest that dams' MetS, induced by fructose intake, disrupts brain redox homeostasis in female offspring and affects sensorimotor brain circuitry which may have a translational value for studying neurodevelopmental diseases.
C1 [Spalm, Facundo H. Prado H.; Sanchez, Marie L. Cuervo; Furland, Natalia E.; Valles, Ana S.] INIBIBB CONICET UNS, Nutr & Neurodev Lab, Bahia Blanca, Argentina.
   [Valles, Ana S.] INIBIBB CONICET UNS, Nutr & Neurodev Lab, Camino Carrindanga Km 7, RA-8000 Bahia Blanca, Buenos Aires, Argentina.
RP Vallés, AS (corresponding author), INIBIBB CONICET UNS, Nutr & Neurodev Lab, Camino Carrindanga Km 7, RA-8000 Bahia Blanca, Buenos Aires, Argentina.
EM sofiavalles@gmail.com
RI Vallés, Ana/GVU-5374-2022
OI Prado Spalm, Facundo Heber/0009-0008-5163-8756
FU Consejo Nacional de Investigaciones Cientificas y Tecnicas
   [PUE22920170100017CO]; Agencia Nacional de Promocion de la Ciencia y la
   Tecnologia [PICT2018-01182]; Universidad Nacional del Sur [PGI 24/B311,
   PGI24/B76, PGI24/B302]
FX Consejo Nacional de Investigaciones Cientificas y Tecnicas, Grant/Award
   Number: PUE22920170100017CO; Agencia Nacional de Promocion de la Ciencia
   y la Tecnologia, Grant/Award Number: PICT2018-01182; Universidad
   Nacional del Sur, Grant/Award Numbers: PGI 24/B311, PGI24/B76,
   PGI24/B302
CR AEBI H, 1984, METHOD ENZYMOL, V105, P121
   Alley DE, 2010, J GERONTOL A-BIOL, V65, P111, DOI 10.1093/gerona/glp177
   Almeda-Valdés P, 2009, ANN HEPATOL, V8, pS18, DOI 10.1016/S1665-2681(19)31822-8
   ALTMAN J, 1975, ANIM BEHAV, V23, P896, DOI 10.1016/0003-3472(75)90114-1
   Ando K, 2009, FREE RADICAL BIO MED, V47, P213, DOI 10.1016/j.freeradbiomed.2009.04.030
   Anekar A. A., 2021, ENCY CLIN NEUROPSYCH, P1853
   Asghar ZA, 2016, SCI REP-UK, V6, DOI 10.1038/srep25091
   Bilbo SD, 2010, FASEB J, V24, P2104, DOI 10.1096/fj.09-144014
   Blaton Victor, 2007, EJIFCC, V18, P15
   Bonnin A, 2011, NEUROSCIENCE, V197, P1, DOI 10.1016/j.neuroscience.2011.10.005
   BREDER CD, 1995, J COMP NEUROL, V355, P296, DOI 10.1002/cne.903550208
   Calabria L. K., 2013, ISRN NEUROSCIENCE, V2013
   Castro MC, 2014, BBA-GEN SUBJECTS, V1840, P1145, DOI 10.1016/j.bbagen.2013.12.005
   Ching RHH, 2011, J NUTR, V141, P1664, DOI 10.3945/jn.111.142299
   Cho G. J., 2018, ENDO 2018 100 ANN M
   Choi CS, 2015, J NUTR BIOCHEM, V26, P1520, DOI 10.1016/j.jnutbio.2015.07.018
   Choudhary Prema Ram, 2018, Journal of Dietary Supplements, V15, P499, DOI 10.1080/19390211.2017.1358233
   Cigliano L, 2018, MOL NEUROBIOL, V55, P2869, DOI 10.1007/s12035-017-0518-2
   Cirulli F, 2013, CAM HBK BEHAV GENET, P88
   Coronati M, 2022, NUTRIENTS, V14, DOI 10.3390/nu14061127
   Costa LG, 2004, ANNU REV PHARMACOL, V44, P87, DOI 10.1146/annurev.pharmtox.44.101802.121424
   Council NR, 1995, NUTR REQ LAB AN
   Dekker MJ, 2010, AM J PHYSIOL-ENDOC M, V299, pE685, DOI 10.1152/ajpendo.00283.2010
   Dencker A, 2016, BMC PREGNANCY CHILDB, V16, DOI 10.1186/s12884-016-0969-x
   Denizli M, 2022, FRONT CELL INFECT MI, V12, DOI 10.3389/fcimb.2022.940937
   Dias JP, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012622
   DiNicolantonio J. J., 2018, PROG CARDIOVASC DIS
   ELLMAN GL, 1959, ARCH BIOCHEM BIOPHYS, V82, P70, DOI 10.1016/0003-9861(59)90090-6
   Erdman JW, 2010, J NUTR, V140, P1400, DOI 10.3945/jn.110.123851
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Flagel SB, 2002, AM J PHYSIOL-REG I, V282, pR55, DOI 10.1152/ajpregu.2002.282.1.R55
   Godfrey KM, 2000, AM J CLIN NUTR, V71, p1344S, DOI 10.1093/ajcn/71.5.1344s
   Gonçalves LK, 2017, NEUROSCI LETT, V661, P29, DOI 10.1016/j.neulet.2017.09.042
   Gopez JJ, 2005, NEUROSURGERY, V56, P590, DOI 10.1227/01.NEU.0000154060.14900.8F
   Guillemot-Legris O, 2017, TRENDS NEUROSCI, V40, P237, DOI 10.1016/j.tins.2017.02.005
   Heyser Charles J, 2004, Curr Protoc Neurosci, VChapter 8, DOI 10.1002/0471142301.ns0818s25
   Ho D, 2022, INT J DEV NEUROSCI, V82, P815, DOI 10.1002/jdn.10235
   Hopps E, 2010, NUTR METAB CARDIOVAS, V20, P72, DOI 10.1016/j.numecd.2009.06.002
   Horvath Gabor, 2015, Adv Neurobiol, V10, P149, DOI 10.1007/978-1-4939-1372-5_8
   Hsu CN, 2016, FRONT PHYSIOL, V7, DOI 10.3389/fphys.2016.00299
   Huang WC, 1999, NEUROSCI LETT, V275, P25, DOI 10.1016/S0304-3940(99)00704-1
   Janssen I, 2002, AM J CLIN NUTR, V75, P683, DOI 10.1093/ajcn/75.4.683
   Jiménez JA, 2021, J NEURODEV DISORD, V13, DOI 10.1186/s11689-020-09353-y
   Johnson RJ, 2007, AM J CLIN NUTR, V86, P899
   Kakkar R, 1997, LIFE SCI, V60, P667, DOI 10.1016/S0024-3205(96)00702-3
   Kuang HZ, 2014, J NUTR BIOCHEM, V25, P985, DOI 10.1016/j.jnutbio.2014.04.012
   Leitner Y, 2000, J CHILD NEUROL, V15, P781, DOI 10.1177/088307380001501202
   Li YK, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/1571705
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   Lumey LH, 2011, ANNU REV PUBL HEALTH, V32, P237, DOI 10.1146/annurev-publhealth-031210-101230
   Mizuno G, 2021, NUTR RES, V92, P40, DOI 10.1016/j.nutres.2021.06.002
   Mortensen OH, 2014, J CEREBR BLOOD F MET, V34, P1205, DOI 10.1038/jcbfm.2014.72
   Nguyen AT, 2017, JOVE-J VIS EXP, DOI 10.3791/55261
   Nishimura Y, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/6685204
   Novelli ELB, 2007, LAB ANIM-UK, V41, P111, DOI 10.1258/002367707779399518
   O'Connor TM, 2006, PEDIATRICS, V118, pE1010, DOI 10.1542/peds.2005-2348
   Ochoa M, 2014, APPL ANIM BEHAV SCI, V157, P61, DOI 10.1016/j.applanim.2014.05.010
   OJEDA SR, 2006, PHYSL REPROD, P2061
   Rains ME, 2021, BRAIN SCI, V11, DOI 10.3390/brainsci11010078
   Redondo N, 2014, FOOD FUNCT, V5, P1686, DOI [10.1039/c4fo00181h, 10.1039/C4FO00181H]
   Rehman K, 2016, CRIT REV EUKAR GENE, V26, P317, DOI 10.1615/CritRevEukaryotGeneExpr.2016016782
   Rice D, 2000, ENVIRON HEALTH PERSP, V108, P511, DOI 10.1289/ehp.00108s3511
   Rivell A, 2019, TRENDS NEUROSCI, V42, P709, DOI 10.1016/j.tins.2019.08.006
   Rivera HM, 2015, FRONT NEUROSCI-SWITZ, V9, DOI 10.3389/fnins.2015.00194
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Rodrigo S, 2016, MOL NUTR FOOD RES, V60, P2700, DOI 10.1002/mnfr.201600193
   Rutledge AC, 2007, NUTR REV, V65, pS13, DOI 10.1301/nr.2007.jun.S13-S23
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Saltiel AR, 2017, J CLIN INVEST, V127, P1, DOI [10.1172/JCI92035, 10.1172/jci92035]
   Schaffler A., 2022, INNERE MED HEIDELBER, V64, P313
   Shi YN, 2021, CHINESE MED J-PEKING, V134, P1276, DOI 10.1097/CM9.0000000000001545
   SIMSON EL, 1982, PHYSIOL BEHAV, V29, P371, DOI 10.1016/0031-9384(82)90028-2
   Singh A, 2019, MOLECULES, V24, DOI 10.3390/molecules24081583
   Smirnov K, 2019, BEHAV BRAIN RES, V374, DOI 10.1016/j.bbr.2019.112143
   Smith EVL, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms232012215
   Soujanya M. G. S., 2014, J INFERT REPROD BIOL, V2, P115
   Spagnuolo MS, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010001
   Tain YL, 2018, NUTRIENTS, V10, DOI 10.3390/nu10010056
   Tain YL, 2014, J PINEAL RES, V57, P80, DOI 10.1111/jpi.12145
   ter Horst KW, 2017, NUTRIENTS, V9, DOI 10.3390/nu9090981
   Thomas EL, 2012, OBESITY, V20, P76, DOI 10.1038/oby.2011.142
   Vickers MH, 2011, ENDOCRINOLOGY, V152, P1378, DOI 10.1210/en.2010-1093
   Vos Miriam B, 2008, Medscape J Med, V10, P160
   Weiss R, 2013, ANN NY ACAD SCI, V1281, P123, DOI 10.1111/nyas.12030
   Wells PG, 2009, TOXICOL SCI, V108, P4, DOI 10.1093/toxsci/kfn263
   Williams L, 2014, BBA-MOL BASIS DIS, V1842, P507, DOI 10.1016/j.bbadis.2013.07.006
   Workman AD, 2013, J NEUROSCI, V33, P7368, DOI 10.1523/JNEUROSCI.5746-12.2013
   World Health Organization, 2015, NUTR FOOD SAF
   Wu CW, 2019, AM J PHYSIOL-ENDOC M, V316, pE622, DOI 10.1152/ajpendo.00408.2018
   Wu KLH, 2016, NEUROBIOL LEARN MEM, V130, P105, DOI 10.1016/j.nlm.2016.02.004
   Yamazaki M, 2018, FASEB J, V32, P2549, DOI 10.1096/fj.201700783RR
   Yang LL, 2017, AM J PUBLIC HEALTH, V107, P1095, DOI 10.2105/AJPH.2017.303762
   Zeiss CJ, 2021, TOXICOL PATHOL, V49, P1368, DOI 10.1177/01926233211046933
NR 93
TC 2
Z9 2
U1 2
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1932-8451
EI 1932-846X
J9 DEV NEUROBIOL
JI Dev. Neurobiol.
PD JUL
PY 2023
VL 83
IS 5-6
BP 167
EP 183
DI 10.1002/dneu.22921
EA JUL 2023
PG 17
WC Developmental Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology; Neurosciences & Neurology
GA R8LD1
UT WOS:001026906700001
PM 37435772
OA Bronze
DA 2025-06-11
ER

PT J
AU Zakariaa, EM
   Abdel-Ghanya, RH
   Elgharbawya, AS
   Alsemeh, AE
   Metwallya, SS
AF Zakariaa, Esraa M.
   Abdel-Ghanya, Rasha H.
   Elgharbawya, Atef S.
   Alsemeh, Amira Ebrahim
   Metwallya, Sami S.
TI A novel approach to repositioning memantine for metabolic
   syndrome-induced steatohepatitis: Modulation of hepatic autophagy,
   inflammation, and fibrosis
SO LIFE SCIENCES
LA English
DT Article
DE Memantine; Nonalcoholic steatohepatitis; Hepatic autophagy; Metabolic
   syndrome; Oxidative stress; Pioglitazone
ID FATTY LIVER-DISEASE; OXIDATIVE STRESS; OBESITY; PIOGLITAZONE; RECEPTORS;
   SYSTEM; RATS; DIET
AB Aims: This study investigated the possible hepatoprotective effects of memantine, compared to pioglitazone, in rat steatohepatitis, emphasizing its role in modulating hepatic autophagy.Main methods: Metabolic syndrome (MetS) was provoked in adult male Wistar rats by a high fructose/fat/salt regimen for eight weeks. Then, rats were administered either memantine or pioglitazone daily for 10 weeks (both at 20 mg/kg, orally). An oral glucose tolerance test (OGTT) was done at the end of the study, and serum liver enzymes, lipids, and fasting blood glucose were measured. Also, hepatic contents of inflammatory, oxidative, and autophagy markers were quantified. Additionally, histopathological examinations of general hepatic structure and glycogen content were performed.Key findings: Compared to the MetS rats, memantine normalized fasting serum insulin, Homeostatic Model Assessment (HOMA-IR), serum lipids, and liver enzymes (ALT and AST). Memantine also markedly reduced hepatic inflammatory markers; NF-kappa B and TNF-alpha. In addition, hepatic NRF2 and GSH were augmented, while hepatic MDA was reduced by memantine. Interestingly, livers of the memantine group showed elevated Beclin1 and LC3 and reduced p62 contents compared to the MetS group indicating that memantine preserved hepatic autophagy. Histopathological examination revealed that memantine ameliorated hepatic steatosis and inflam-mation. Pioglitazone also mitigated most of the steatohepatitis-related changes, however, memantine was more effective in most of the studied parameters.Significance: The hepatoprotective effect of memantine against steatohepatitis is mediated, at least partly, through conserving hepatic autophagy along with anti-inflammatory, antioxidant, and anti-fibrotic effects.
C1 [Zakariaa, Esraa M.; Abdel-Ghanya, Rasha H.; Elgharbawya, Atef S.; Metwallya, Sami S.] Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig 44519, Egypt.
   [Alsemeh, Amira Ebrahim] Zagazig Univ, Fac Med, Dept Anat, Zagazig 44519, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Egyptian Knowledge
   Bank (EKB); Zagazig University
RP Zakariaa, EM (corresponding author), Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig 44519, Egypt.
EM emzakaria@zu.edu.eg
RI Zakaria, Esraa Mohammed Naguib/GYD-7862-2022; Alsemeh,
   Amira/LWH-9728-2024
OI , Esraa M Zakaria/0000-0002-1132-2254; Salah, Sami/0009-0009-1767-3897
CR Abd El-Hameed NM, 2021, LIFE SCI, V285, DOI 10.1016/j.lfs.2021.119983
   Ahmadian E, 2017, DRUG RES, V67, P217, DOI 10.1055/s-0042-123034
   Amin SN, 2017, CAN J PHYSIOL PHARM, V95, P721, DOI 10.1139/cjpp-2016-0556
   Amir M, 2011, EXPERT REV GASTROENT, V5, P159, DOI [10.1586/egh.11.4, 10.1586/EGH.11.4]
   Bae YS, 2022, EXP MOL MED, V54, P1109, DOI 10.1038/s12276-022-00818-9
   Bjorkoy G, 2009, METHOD ENZYMOL, V452, P181, DOI 10.1016/S0076-6879(08)03612-4
   Bozic M, 2015, EXPERT OPIN THER TAR, V19, P399, DOI 10.1517/14728222.2014.983900
   Chen ZG, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0572-9
   Collino M, 2010, BRIT J PHARMACOL, V160, P1892, DOI 10.1111/j.1476-5381.2010.00671.x
   Cui F, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.00013
   Deng SN, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00015
   Dietrich P, 2014, BEST PRACT RES CL GA, V28, P637, DOI 10.1016/j.bpg.2014.07.008
   Eftekhari A, 2016, XENOBIOTICA, V46, P369, DOI 10.3109/00498254.2015.1078522
   Esteghamati A, 2010, NUTR METAB, V7, DOI 10.1186/1743-7075-7-26
   Ferreira Marcelo, 2011, Int Arch Med, V4, P5, DOI 10.1186/1755-7682-4-5
   Glick D, 2010, J PATHOL, V221, P3, DOI 10.1002/path.2697
   He CC, 2010, CURR OPIN CELL BIOL, V22, P140, DOI 10.1016/j.ceb.2010.01.001
   He Q, 2016, BIOCHEM BIOPH RES CO, V476, P196, DOI 10.1016/j.bbrc.2016.05.086
   Hegazy M, 2020, EUR J PHARMACOL, V885, DOI 10.1016/j.ejphar.2020.173383
   Hirano K, 2019, BIOCHEM BIOPH RES CO, V518, P161, DOI 10.1016/j.bbrc.2019.08.025
   Hsiao PJ, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-09702-3
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Huang XT, 2021, THERANOSTICS, V11, P2247, DOI 10.7150/thno.51666
   Ibrahim SM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0117516
   JEEVANANDAM M, 1991, METABOLISM, V40, P385, DOI 10.1016/0026-0495(91)90149-Q
   Jeong O, 2019, NUTR METAB, V16, DOI 10.1186/s12986-019-0364-5
   Kawaguchi K, 2004, BIOCHEM BIOPH RES CO, V315, P187, DOI 10.1016/J.BBRC.2004.01.038
   Khalaf SS, 2019, N-S ARCH PHARMACOL, V392, P685, DOI 10.1007/s00210-019-01616-3
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Kouroumalis E, 2021, WORLD J HEPATOL, V13, DOI 10.4254/wjh.v13.i1.6
   Koyama Y, 2017, J CLIN INVEST, V127, P55, DOI 10.1172/JCI88881
   Kucera O, 2014, WORLD J GASTROENTERO, V20, P8364, DOI 10.3748/wjg.v20.i26.8364
   Lark D S, 2012, Int J Obes Suppl, V2, pS31
   Lavallard VJ, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/120179
   Li P, 2021, BMC NEUROSCI, V22, DOI 10.1186/s12868-021-00647-y
   Liu HY, 2009, J BIOL CHEM, V284, P31484, DOI 10.1074/jbc.M109.033936
   Lupp A, 2003, EXP TOXICOL PATHOL, V54, P441, DOI 10.1078/0940-2993-00280
   Ma XW, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9040837
   Malhi H, 2008, SEMIN LIVER DIS, V28, P360, DOI 10.1055/s-0028-1091980
   Malnick SDH, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms232416226
   Maltais-Payette I, 2019, NUTR METAB CARDIOVAS, V29, P1353, DOI 10.1016/j.numecd.2019.08.015
   Namkoong S, 2018, MOL CELLS, V41, P3, DOI 10.14348/molcells.2018.2213
   Novelli ELB, 2007, LAB ANIM-UK, V41, P111, DOI 10.1258/002367707779399518
   Panchal SK, 2012, J NUTR, V142, P1026, DOI 10.3945/jn.111.157263
   Rada P, 2020, CELL DEATH DIS, V11, DOI 10.1038/s41419-020-03003-w
   Rogov V, 2014, MOL CELL, V53, P167, DOI 10.1016/j.molcel.2013.12.014
   Rojas M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13072254
   Seki E, 2015, HEPATOLOGY, V61, P1066, DOI 10.1002/hep.27332
   Shafiei-Irannejad V, 2021, EUR J PHARMACOL, V910, DOI 10.1016/j.ejphar.2021.174455
   Sharma S, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025269
   Shibl NG, 2022, LIFE SCI, V307, DOI 10.1016/j.lfs.2022.120891
   Smith KL, 2015, NEUROPSYCHOPHARMACOL, V40, P1163, DOI 10.1038/npp.2014.299
   Tanida Isei, 2008, V445, P77, DOI 10.1007/978-1-59745-157-4_4
   Taniguchi K, 2016, FEBS LETT, V590, P2375, DOI 10.1002/1873-3468.12301
   Trocoli A, 2011, AM J CANCER RES, V1, P629
   Wang P, 2008, PHYSIOL BEHAV, V94, P198, DOI 10.1016/j.physbeh.2007.11.008
   Xu Ping, 2006, J Zhejiang Univ Sci B, V7, P627, DOI 10.1631/jzus.2006.B0627
   Xu WH, 2008, LAB INVEST, V88, P1068, DOI 10.1038/labinvest.2008.75
   Yang JM, 2019, WORLD J GASTROENTERO, V25, P5105, DOI 10.3748/wjg.v25.i34.5105
   Yang L, 2010, CELL METAB, V11, P467, DOI 10.1016/j.cmet.2010.04.005
   Yuan GJ, 2004, WORLD J GASTROENTERO, V10, P1047
   Zhang D, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.689111
   Zhao N, 2018, CELL MOL LIFE SCI, V75, P3143, DOI 10.1007/s00018-018-2852-6
   Zhong F, 2020, DIGESTION, V101, P522, DOI 10.1159/000501851
   Zhou W, 2022, CELL DEATH DISCOV, V8, DOI 10.1038/s41420-022-01022-4
NR 65
TC 3
Z9 3
U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD APR 15
PY 2023
VL 319
AR 121509
DI 10.1016/j.lfs.2023.121509
EA MAR 2023
PG 12
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 0A0NA
UT WOS:000951525700001
PM 36822316
DA 2025-06-11
ER

PT J
AU Swiatkiewicz, I
   Mila-Kierzenkowska, C
   Wozniak, A
   Szewczyk-Golec, K
   Nuszkiewicz, J
   Wróblewska, J
   Rajewski, P
   Eussen, SJPM
   Færch, K
   Manoogian, ENC
   Panda, S
   Taub, PR
AF Swiatkiewicz, Iwona
   Mila-Kierzenkowska, Celestyna
   Wozniak, Alina
   Szewczyk-Golec, Karolina
   Nuszkiewicz, Jaroslaw
   Wroblewska, Joanna
   Rajewski, Pawel
   Eussen, Simone J. P. M.
   Faerch, Kristine
   Manoogian, Emily N. C.
   Panda, Satchidananda
   Taub, Pam R.
TI Pilot Clinical Trial of Time-Restricted Eating in Patients with
   Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE time-restricted eating; metabolic syndrome; eating pattern; clinical
   trial; m-health applications; cardiometabolic risks; health outcomes;
   body weight; circadian rhythm; dietary assessment methodologies
AB Metabolic syndrome (MetS) and erratic eating patterns are associated with circadian rhythm disruption which contributes to an increased cardiometabolic risks. Restricting eating period (time-restricted eating, TRE) can restore robust circadian rhythms and improve cardiometabolic health. We describe a protocol of the Time-Restricted Eating on Metabolic and Neuroendocrine homeostasis, Inflammation, and Oxidative Stress (TREMNIOS) pilot clinical trial in Polish adult patients with MetS and eating period of >= 14 h/day. The study aims to test the feasibility of TRE intervention and methodology for evaluating its efficacy for improving metabolic, neuroendocrine, inflammatory, oxidative stress and cardiac biomarkers, and daily rhythms of behavior for such population. Participants will apply 10-h TRE over a 12-week monitored intervention followed by a 12-week self-directed intervention. Changes in eating window, body weight and composition, biomarkers, and rhythms of behavior will be evaluated. Dietary intake, sleep, activity and wellbeing will be monitored with the myCircadianClock application and questionnaires. Adherence to TRE defined as the proportion of days recorded with app during the monitored intervention in which participants satisfied 10-h TRE is the primary outcome. TREMNIOS will also provide an exploratory framework to depict post-TRE changes in cardiometabolic outcomes and behavior rhythms. This protocol extends previous TRE-related protocols by targeting European population with diagnosed MetS and including long-term intervention, validated tools for monitoring dietary intake and adherence, and comprehensive range of biomarkers. TREMNIOS trial will lay the groundwork for a large-scale randomized controlled trial to determine TRE efficacy for improving cardiometabolic health in MetS population.
C1 [Swiatkiewicz, Iwona] Nicolaus Copernicus Univ, Coll Med, Dept Cardiol & Internal Med, PL-85094 Bydgoszcz, Poland.
   [Swiatkiewicz, Iwona; Taub, Pam R.] Univ Calif San Diego, Div Cardiovasc Med, La Jolla, CA 92037 USA.
   [Mila-Kierzenkowska, Celestyna; Wozniak, Alina; Szewczyk-Golec, Karolina; Nuszkiewicz, Jaroslaw; Wroblewska, Joanna] Nicolaus Copernicus Univ, Coll Med, Dept Med Biol & Biochem, PL-85092 Bydgoszcz, Poland.
   [Rajewski, Pawel] Ctr Obes & Metab Disorders Treatment, PL-85676 Bydgoszcz, Poland.
   [Eussen, Simone J. P. M.] Maastricht Univ, Dept Epidemiol, NL-6200 MD Maastricht, Netherlands.
   [Eussen, Simone J. P. M.] Maastricht Univ, Sch Cardiovasc Dis CARIM, NL-6200 MD Maastricht, Netherlands.
   [Faerch, Kristine] Steno Diabet Ctr Copenhagen, DK-2820 Gentofte, Denmark.
   [Faerch, Kristine] Univ Copenhagen, Dept Biomed Sci, DK-2200 Copenhagen, Denmark.
   [Manoogian, Emily N. C.; Panda, Satchidananda] Salk Inst Biol Studies, La Jolla, CA 92037 USA.
C3 Nicolaus Copernicus University; University of California System;
   University of California San Diego; Nicolaus Copernicus University;
   Maastricht University; Maastricht University; Steno Diabetes Center;
   University of Copenhagen; Salk Institute
RP Swiatkiewicz, I (corresponding author), Nicolaus Copernicus Univ, Coll Med, Dept Cardiol & Internal Med, PL-85094 Bydgoszcz, Poland.; Swiatkiewicz, I (corresponding author), Univ Calif San Diego, Div Cardiovasc Med, La Jolla, CA 92037 USA.
EM iwona.swiatkiewicz@gmail.com; celestyna@o2.pl; alina-wozniak@wp.pl;
   karosz@cm.umk.pl; jnuszkiewicz@cm.umk.pl; jwroblewskapraca@gmail.com;
   rajson@wp.pl; simone.eussen@maastrichtuniversity.nl;
   kristine.faerch@regionh.dk; emily.manoogian@gmail.com; panda@salk.edu;
   ptaub@health.ucsd.edu
RI Wróblewska, Joanna/G-8607-2014; Mila-Kierzenkowska,
   Celestyna/F-1858-2014; eussen, simone/JAC-5744-2023; Swiatkiewicz,
   Iwona/H-4279-2014; Szewczyk-Golec, Karolina/E-9110-2014; Wozniak,
   Alina/H-4699-2014; Nuszkiewicz, Jaroslaw/AAI-6787-2021
OI Faerch, Kristine/0000-0002-6127-0448; Taub, Pam/0000-0002-0684-0655;
   Manoogian, Emily Nicole/0000-0001-9718-9310; Rajewski,
   Pawel/0000-0001-9796-8840; Szewczyk-Golec, Karolina/0000-0001-8123-3882;
   Wozniak, Alina/0000-0002-4492-4796; Wroblewska,
   Joanna/0000-0002-8188-8296; Nuszkiewicz, Jaroslaw/0000-0003-1378-5065;
   Eussen, Simone/0000-0003-0559-6838
FU Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
FX The study is funded by Collegium Medicum, Nicolaus Copernicus
   University, Bydgoszcz, Poland. This research received no external
   funding.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Anton SD, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071500
   Antoni R, 2018, J NUTR SCI, V7, DOI 10.1017/jns.2018.13
   Asher G, 2015, CELL, V161, P84, DOI 10.1016/j.cell.2015.03.015
   Cahill LE, 2013, CIRCULATION, V128, P337, DOI 10.1161/CIRCULATIONAHA.113.001474
   Carlson O, 2007, METABOLISM, V56, P1729, DOI 10.1016/j.metabol.2007.07.018
   Chaix A, 2019, ANNU REV NUTR, V39, P291, DOI 10.1146/annurev-nutr-082018-124320
   Chaix A, 2014, CELL METAB, V20, P991, DOI 10.1016/j.cmet.2014.11.001
   Chellappa SL, 2019, TRENDS ENDOCRIN MET, V30, P767, DOI 10.1016/j.tem.2019.07.008
   Chow LS, 2020, OBESITY, V28, P860, DOI [10.1002/oby.22756, 10.1002/oby.22785]
   Chung H, 2016, METABOLISM, V65, P1743, DOI 10.1016/j.metabol.2016.09.006
   Cienfuegos S, 2020, CELL METAB, V32, P366, DOI 10.1016/j.cmet.2020.06.018
   de Cabo R, 2019, NEW ENGL J MED, V381, P2541, DOI 10.1056/NEJMra1905136
   Eckel RH, 2010, LANCET, V375, P181, DOI 10.1016/S0140-6736(09)61794-3
   Faul F, 2007, BEHAV RES METHODS, V39, P175, DOI 10.3758/BF03193146
   Feinman RD, 2015, NUTRITION, V31, P1, DOI 10.1016/j.nut.2014.06.011
   Franco OH, 2009, CIRCULATION, V120, P1943, DOI 10.1161/CIRCULATIONAHA.109.855817
   Gabel Kelsey, 2018, Nutr Healthy Aging, V4, P345, DOI 10.3233/NHA-170036
   Garaulet M, 2020, TRENDS ENDOCRIN MET, V31, P192, DOI 10.1016/j.tem.2019.11.011
   Gill S, 2015, CELL METAB, V22, P789, DOI 10.1016/j.cmet.2015.09.005
   Gill S, 2015, SCIENCE, V347, P1265, DOI 10.1126/science.1256682
   Gupta NJ, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0172852
   Hatori M, 2012, CELL METAB, V15, P848, DOI 10.1016/j.cmet.2012.04.019
   Heymsfield SB, 2007, AM J CLIN NUTR, V85, P346, DOI 10.1093/ajcn/85.2.346
   Hutchison AT, 2019, OBESITY, V27, P724, DOI 10.1002/oby.22449
   International Diabetes Federation, CONS WORLDW DEF MET
   Jamshed H, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061234
   Kant AK, 2015, J ACAD NUTR DIET, V115, P50, DOI 10.1016/j.jand.2014.06.354
   Kesztyüs D, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122854
   Kubica A, 2015, PHARMACOLOGY, V95, P50, DOI 10.1159/000371392
   LeCheminant JD, 2013, BRIT J NUTR, V110, P2108, DOI 10.1017/S0007114513001359
   Lowe DA, 2020, JAMA INTERN MED, V180, P1491, DOI 10.1001/jamainternmed.2020.4153
   Martens CR, 2020, GEROSCIENCE, V42, P667, DOI 10.1007/s11357-020-00156-6
   Mason IC, 2020, DIABETOLOGIA, V63, P462, DOI 10.1007/s00125-019-05059-6
   McAllister MJ, 2020, NUTR RES, V75, P32, DOI 10.1016/j.nutres.2019.12.001
   Moro T, 2016, J TRANSL MED, V14, DOI 10.1186/s12967-016-1044-0
   Panda S, 2016, SCIENCE, V354, P1008, DOI 10.1126/science.aah4967
   Parr EB, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113228
   Parr EB, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020505
   Pot GK, 2016, P NUTR SOC, V75, P475, DOI 10.1017/S0029665116000239
   Queiroz JD, 2021, CRIT REV FOOD SCI, V61, P2863, DOI 10.1080/10408398.2020.1789550
   Ravussin E, 2019, OBESITY, V27, P1244, DOI 10.1002/oby.22518
   Regmi P, 2020, ISCIENCE, V23, DOI 10.1016/j.isci.2020.101161
   Riou J, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0119161
   Roth GA, 2020, J AM COLL CARDIOL, V76, P2982, DOI 10.1016/j.jacc.2020.11.010
   Scheer FAJL, 2009, P NATL ACAD SCI USA, V106, P4453, DOI 10.1073/pnas.0808180106
   Scuteri A, 2015, EUR J PREV CARDIOL, V22, P486, DOI 10.1177/2047487314525529
   Scuteri A, 2010, EUR HEART J, V31, P602, DOI 10.1093/eurheartj/ehp491
   Sperling LS, 2015, J AM COLL CARDIOL, V66, P1050, DOI 10.1016/j.jacc.2015.06.1328
   St-Onge MP, 2017, CIRCULATION, V135, pE96, DOI 10.1161/CIR.0000000000000476
   Stote KS, 2007, AM J CLIN NUTR, V85, P981, DOI 10.1093/ajcn/85.4.981
   Suliga E, 2017, NUTRIENTS, V9, DOI 10.3390/nu9121366
   Sutton EF, 2018, CELL METAB, V27, P1212, DOI 10.1016/j.cmet.2018.04.010
   Swiatkiewicz I, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010221
   Swiatkiewicz I, 2018, KARDIOL POL, V76, P821, DOI 10.5603/KP.a2018.0091
   Sygnowska E, 2012, KARDIOL POL, V70, P718
   Szewczyk-Golec K, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/8494107
   Szewczyk-Golec K, 2015, J PINEAL RES, V59, P277, DOI 10.1111/jpi.12257
   Tinsley GM, 2019, AM J CLIN NUTR, V110, P628, DOI 10.1093/ajcn/nqz126
   Tinsley GM, 2017, EUR J SPORT SCI, V17, P200, DOI 10.1080/17461391.2016.1223173
   Virani SS, 2020, CIRCULATION, V141, pE139, DOI 10.1161/CIR.0000000000000757
   Vollmers C, 2009, P NATL ACAD SCI USA, V106, P21453, DOI 10.1073/pnas.0909591106
   Wagner R, 2021, NAT MED, V27, P49, DOI 10.1038/s41591-020-1116-9
   Wilkinson MJ, 2020, CELL METAB, V31, P92, DOI 10.1016/j.cmet.2019.11.004
   Zarrinpar A, 2016, TRENDS ENDOCRIN MET, V27, P69, DOI 10.1016/j.tem.2015.11.007
NR 65
TC 15
Z9 16
U1 0
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2021
VL 13
IS 2
AR 346
DI 10.3390/nu13020346
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA QO1LZ
UT WOS:000622909600001
PM 33498955
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU June, RK
   Liu-Bryan, R
   Long, FX
   Griffin, TM
AF June, Ronald K.
   Liu-Bryan, Ru
   Long, Fanxing
   Griffin, Timothy M.
TI Emerging role of metabolic signaling in synovial joint remodeling and
   osteoarthritis
SO JOURNAL OF ORTHOPAEDIC RESEARCH
LA English
DT Review
DE metabolic syndrome; obesity; bone; cartilage; osteoarthritis
ID ACTIVATED PROTEIN-KINASE; ENDOPLASMIC-RETICULUM STRESS; RADIOGRAPHIC
   KNEE OSTEOARTHRITIS; MITOCHONDRIAL DYSFUNCTION; CATABOLIC RESPONSES;
   GENE-EXPRESSION; ADIPOSE-TISSUE; LIFETIME RISK; NITRIC-OXIDE; OBESITY
AB Obesity and associated metabolic diseases collectively referred to as the metabolic syndrome increase the risk of skeletal and synovial joint diseases, including osteoarthritis (OA). The relationship between obesity and musculoskeletal diseases is complex, involving biomechanical, dietary, genetic, inflammatory, and metabolic factors. Recent findings illustrate how changes in cellular metabolism and metabolic signaling pathways alter skeletal development, remodeling, and homeostasis, especially in response to biomechanical and inflammatory stressors. Consequently, a better understanding of the energy metabolism of diarthrodial joint cells and tissues, including bone, cartilage, and synovium, may lead to new strategies to treat or prevent synovial joint diseases such as OA. This rationale was the basis of a workshop presented at the 2016 Annual ORS Meeting in Orlando, FL on the emerging role of metabolic signaling in synovial joint remodeling and OA. The topics we covered included (i) the relationship between metabolic syndrome and OA in clinical and pre-clinical studies; (ii) the effect of biomechanical loading on chondrocyte metabolism; (iii) the effect of Wnt signaling on osteoblast carbohydrate and amino acid metabolism with respect to bone anabolism; and (iv) the role of AMP-activated protein kinase in chondrocyte energetic and biomechanical stress responses in the context of cartilage injury, aging, and OA. Although challenges exist for measuring in vivo changes in synovial joint tissue metabolism, the findings presented herein provide multiple lines of evidence to support a central role for disrupted cellular energy metabolism in the pathogenesis of OA. (c) 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:2048-2058, 2016.
C1 [June, Ronald K.] Montana State Univ, Dept Mech & Ind Engn, POB 173800, Bozeman, MT 59717 USA.
   [June, Ronald K.] Montana State Univ, Dept Cell Biol & Neurosci, POB 173800, Bozeman, MT 59717 USA.
   [Liu-Bryan, Ru] Univ Calif San Diego, Dept Med, VA San Diego Healthcare Syst, San Diego, CA 92103 USA.
   [Long, Fanxing] Washington Univ, Sch Med, Dept Dev Biol, Dept Orthopaed Surg, St Louis, MO USA.
   [Griffin, Timothy M.] Oklahoma Med Res Fdn, Aging & Metab Res Program, 825 NE 13th St,MS 21, Oklahoma City, OK 73104 USA.
   [Griffin, Timothy M.] Univ Oklahoma, Hlth Sci Ctr, Dept Biochem & Mol Biol, 825 NE 13th St,MS 21, Oklahoma City, OK 73104 USA.
   [Griffin, Timothy M.] Univ Oklahoma, Hlth Sci Ctr, Dept Physiol, 825 NE 13th St,MS 21, Oklahoma City, OK 73104 USA.
   [Griffin, Timothy M.] Univ Oklahoma, Hlth Sci Ctr, Dept Geriatr Med, 825 NE 13th St,MS 21, Oklahoma City, OK 73104 USA.
C3 Montana State University System; Montana State University Bozeman;
   Montana State University System; Montana State University Bozeman;
   University of California System; University of California San Diego; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   San Diego Healthcare System; Washington University (WUSTL); Oklahoma
   Medical Research Foundation; University of Oklahoma System; University
   of Oklahoma Health Sciences Center; University of Oklahoma System;
   University of Oklahoma Health Sciences Center; University of Oklahoma
   System; University of Oklahoma Health Sciences Center
RP June, RK (corresponding author), Montana State Univ, Dept Mech & Ind Engn, POB 173800, Bozeman, MT 59717 USA.; June, RK (corresponding author), Montana State Univ, Dept Cell Biol & Neurosci, POB 173800, Bozeman, MT 59717 USA.; Griffin, TM (corresponding author), Oklahoma Med Res Fdn, Aging & Metab Res Program, 825 NE 13th St,MS 21, Oklahoma City, OK 73104 USA.; Griffin, TM (corresponding author), Univ Oklahoma, Hlth Sci Ctr, Dept Biochem & Mol Biol, 825 NE 13th St,MS 21, Oklahoma City, OK 73104 USA.; Griffin, TM (corresponding author), Univ Oklahoma, Hlth Sci Ctr, Dept Physiol, 825 NE 13th St,MS 21, Oklahoma City, OK 73104 USA.; Griffin, TM (corresponding author), Univ Oklahoma, Hlth Sci Ctr, Dept Geriatr Med, 825 NE 13th St,MS 21, Oklahoma City, OK 73104 USA.
EM rjune@montana.edu; tim-griffin@omrf.org
RI Griffin, Timothy/V-8838-2019
FU National Institute of Arthritis and Musculoskeletal and Skin Diseases
   [R01 AR060456, AR055923, R01AR1067966, R03AR066828]; National Institute
   on Aging [R01AG049058]; Department of Veterans Affairs [1I01BX002234];
   Arthritis Foundation [6045]; National Science Foundation [1342420,
   1554708]; Div Of Civil, Mechanical, & Manufact Inn; Directorate For
   Engineering [1342420, 1554708] Funding Source: National Science
   Foundation
FX Grant sponsor: National Institute of Arthritis and Musculoskeletal and
   Skin Diseases; Grant numbers: R01 AR060456, AR055923, R01AR1067966,
   R03AR066828; Grant sponsor: National Institute on Aging; Grant number:
   R01AG049058; Grant sponsor: Department of Veterans Affairs; Grant
   number: 1I01BX002234; Grant sponsor: Arthritis Foundation; Grant number:
   6045; Grant sponsor: National Science Foundation; Grant numbers:
   1342420, 1554708.
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Alberts B., 2002, Molecular Biology of the Cell, V4
   Berenbaum F, 2013, OSTEOARTHR CARTILAGE, V21, P16, DOI 10.1016/j.joca.2012.11.012
   Blanco FJ, 2004, MITOCHONDRION, V4, P715, DOI 10.1016/j.mito.2004.07.022
   Blanco FJ, 2011, NAT REV RHEUMATOL, V7, P161, DOI 10.1038/nrrheum.2010.213
   Bohensky J, 2010, PEDIATR NEPHROL, V25, P633, DOI 10.1007/s00467-009-1310-y
   BORLE AB, 1960, J BIOL CHEM, V235, P1206
   Brooks PM, 2006, CLIN RHEUMATOL, V25, P778, DOI 10.1007/s10067-006-0240-3
   Calvet J, 2016, SCAND J RHEUMATOL, V45, P41, DOI 10.3109/03009742.2015.1054875
   Caramés B, 2012, ARTHRITIS RHEUM-US, V64, P1182, DOI 10.1002/art.33444
   Caramés B, 2010, ARTHRITIS RHEUM-US, V62, P791, DOI 10.1002/art.27305
   Chu CR, 2015, J ORTHOP RES, V33, P939, DOI 10.1002/jor.22817
   COHN DV, 1962, J BIOL CHEM, V237, P615
   Coleman MC, 2016, ARTHRITIS RHEUMATOL, V68, P662, DOI 10.1002/art.39460
   Courties A, 2015, OSTEOARTHR CARTILAGE, V23, P1955, DOI 10.1016/j.joca.2015.05.016
   de Munter W, 2016, RHEUMATOLOGY, V55, P16, DOI 10.1093/rheumatology/kev270
   Dufey E, 2014, AM J PHYSIOL-CELL PH, V307, pC582, DOI 10.1152/ajpcell.00258.2014
   Dumond H, 2003, ARTHRITIS RHEUM, V48, P3118, DOI 10.1002/art.11303
   Engström G, 2009, OSTEOARTHR CARTILAGE, V17, P168, DOI 10.1016/j.joca.2008.07.003
   Esen E, 2015, J BONE MINER RES, V30, P1959, DOI 10.1002/jbmr.2556
   Esen E, 2014, CURR OSTEOPOROS REP, V12, P433, DOI 10.1007/s11914-014-0235-y
   Esen E, 2013, CELL METAB, V17, P745, DOI 10.1016/j.cmet.2013.03.017
   Eymard F, 2015, OSTEOARTHR CARTILAGE, V23, P851, DOI 10.1016/j.joca.2015.01.013
   Fowler-Brown A, 2015, ARTHRITIS RHEUMATOL, V67, P169, DOI 10.1002/art.38913
   Fullerton MD, 2013, MOL CELL ENDOCRINOL, V366, P224, DOI 10.1016/j.mce.2012.02.004
   Gierman LM, 2014, ANN RHEUM DIS, V73, P921, DOI 10.1136/annrheumdis-2013-203248
   Griffin TM, 2016, BIOCHIMIE, V124, P74, DOI 10.1016/j.biochi.2015.10.013
   Griffin TM, 2010, ARTHRITIS RES THER, V12, DOI 10.1186/ar3068
   Hamada D, 2016, ARTHRITIS RHEUMATOL, V68, P1392, DOI 10.1002/art.39561
   Hardie DG, 2012, CHEM BIOL, V19, P1222, DOI 10.1016/j.chembiol.2012.08.019
   Hawker GA, 2014, OSTEOARTHR CARTILAGE, V22, P1953, DOI 10.1016/j.joca.2014.06.018
   Hoeven TA, 2013, ANN RHEUM DIS, V72, P646, DOI 10.1136/annrheumdis-2011-201178
   Hosseini A, 2010, OSTEOARTHR CARTILAGE, V18, P909, DOI 10.1016/j.joca.2010.04.011
   Hui W, 2012, ANN RHEUM DIS, V71, P455, DOI 10.1136/annrheumdis-2011-200372
   Husa M, 2013, ARTHRITIS RES THER, V15, DOI 10.1186/ar4415
   Hussain SM, 2014, SEMIN ARTHRITIS RHEU, V43, P429, DOI 10.1016/j.semarthrit.2013.07.013
   Hwang JT, 2009, NEW BIOTECHNOL, V26, P17, DOI 10.1016/j.nbt.2009.03.005
   Issa RI, 2012, PATHOBIOL AGING AGE, V2, DOI 10.3402/pba.v2i0.17470
   Johnson CH, 2016, NAT REV MOL CELL BIO, V17, P451, DOI 10.1038/nrm.2016.25
   Jutila AA, 2014, ARCH BIOCHEM BIOPHYS, V545, P116, DOI 10.1016/j.abb.2014.01.011
   Kaelin WG, 2013, CELL, V153, P56, DOI 10.1016/j.cell.2013.03.004
   Karner CM, 2016, J BIOL CHEM, V291, P13028, DOI 10.1074/jbc.M115.708578
   Karner CM, 2015, J CLIN INVEST, V125, P551, DOI 10.1172/JCI78470
   Karvonen-Gutierrez CA, 2012, OSTEOARTHR CARTILAGE, V20, P614, DOI 10.1016/j.joca.2012.02.644
   Karvonen-Gutierrez CA, 2014, ANN RHEUM DIS, V73, P883, DOI 10.1136/annrheumdis-2012-202685
   Katz JD, 2010, CURR OPIN RHEUMATOL, V22, P512, DOI 10.1097/BOR.0b013e32833bfb4b
   KIAER T, 1988, CLIN ORTHOP RELAT R, P149
   Kluzek S, 2015, BIOMARKERS, V20, P519, DOI 10.3109/1354750X.2014.948914
   Lamming DW, 2013, J CLIN INVEST, V123, P980, DOI 10.1172/JCI64099
   Lane RS, 2015, ARTHRITIS RES THER, V17, DOI 10.1186/s13075-015-0566-9
   Le Clanche S, 2016, BIOCHIMIE, V121, P238, DOI 10.1016/j.biochi.2015.12.008
   Lee S, 2015, MOD RHEUMATOL, V25, P292, DOI 10.3109/14397595.2014.939393
   Liu TF, 2012, J LEUKOCYTE BIOL, V92, P499, DOI 10.1189/jlb.0212078
   Liu-Bryan R, 2016, ARTHRITIS RHEUM, V66, pS1288
   López-Otín C, 2013, CELL, V153, P1194, DOI 10.1016/j.cell.2013.05.039
   Losina E, 2013, ARTHRIT CARE RES, V65, P703, DOI 10.1002/acr.21898
   Marsin AS, 2000, CURR BIOL, V10, P1247, DOI 10.1016/S0960-9822(00)00742-9
   Martel-Pelletier J, 2016, RHEUMATOLOGY, V55, P680, DOI 10.1093/rheumatology/kev408
   Messier SP, 2009, MED CLIN N AM, V93, P145, DOI 10.1016/j.mcna.2008.09.011
   Miller RH, 2015, GAIT POSTURE, V41, P326, DOI 10.1016/j.gaitpost.2014.10.009
   Minor CA, 2015, ANN M ORS 2015 LAS V
   Morrell KC, 2005, P NATL ACAD SCI USA, V102, P14819, DOI 10.1073/pnas.0507117102
   Muoio DM, 2014, CELL, V159, P1253, DOI 10.1016/j.cell.2014.11.034
   Murphy L, 2008, ARTHRIT RHEUM-ARTHR, V59, P1207, DOI 10.1002/art.24021
   Muthuri SG, 2011, ARTHRIT CARE RES, V63, P982, DOI 10.1002/acr.20464
   NAJAFIPOUR H, 1995, EXP PHYSIOL, V80, P209, DOI 10.1113/expphysiol.1995.sp003841
   Nelson D.L., 2008, LEHNIGER PRINCIPLES, V4th
   Neumann E, 2016, NAT REV RHEUMATOL, V12, P296, DOI 10.1038/nrrheum.2016.49
   O'Neill LAJ, 2013, NATURE, V493, P346, DOI 10.1038/nature11862
   Oliver BL, 2005, J CELL PHYSIOL, V204, P45, DOI 10.1002/jcp.20261
   Peansukmanee S, 2009, J ORTHOP RES, V27, P529, DOI 10.1002/jor.20772
   PECK WA, 1964, SCIENCE, V146, P1476, DOI 10.1126/science.146.3650.1476
   Petursson F, 2013, ARTHRITIS RES THER, V15, DOI 10.1186/ar4254
   Puenpatom RA, 2009, POSTGRAD MED, V121, P9, DOI 10.3810/pgm.2009.11.2073
   Rai MF, 2011, CRIT REV EUKAR GENE, V21, P131, DOI 10.1615/CritRevEukarGeneExpr.v21.i2.30
   Salinas D, 2015, ANN M ORS 2015 LAS V
   Salminen A, 2012, AGEING RES REV, V11, P230, DOI 10.1016/j.arr.2011.12.005
   Sasaki H, 2012, ARTHRITIS RHEUM-US, V64, P1920, DOI 10.1002/art.34323
   Scanzello CR, 2012, BONE, V51, P249, DOI 10.1016/j.bone.2012.02.012
   Sellam J, 2013, JOINT BONE SPINE, V80, P568, DOI 10.1016/j.jbspin.2013.09.007
   Shin D, 2014, J CLIN ENDOCR METAB, V99, P3177, DOI 10.1210/jc.2014-1043
   Shyh-Chang N, 2013, DEVELOPMENT, V140, P2535, DOI 10.1242/dev.091777
   Sowers M, 2009, ARTHRIT CARE RES, V61, P1328, DOI 10.1002/art.24739
   Steinberg GR, 2009, PHYSIOL REV, V89, P1025, DOI [10.1152/physrev.00011.2008, 10.15252/embj.201488104]
   Stephanopoulos G., 1998, METABOLIC ENG PRINCI
   Sutter EG, 2015, AM J SPORT MED, V43, P370, DOI 10.1177/0363546514559821
   Takada K, 2013, BIOMED REP, V1, P315, DOI 10.3892/br.2013.52
   Takada K, 2011, INT J EXP PATHOL, V92, P232, DOI 10.1111/j.1365-2613.2010.00758.x
   Terkeltaub R, 2011, ARTHRITIS RHEUM-US, V63, P1928, DOI 10.1002/art.30333
   Thijssen E, 2015, RHEUMATOLOGY, V54, P588, DOI 10.1093/rheumatology/keu464
   Vaamonde-García C, 2012, ARTHRITIS RHEUM-US, V64, P2927, DOI 10.1002/art.34508
   Visser AW, 2015, ANN RHEUM DIS, V74, P1842, DOI 10.1136/annrheumdis-2013-205012
   Wang X, 2015, OSTEOARTHR CARTILAGE, V23, P22, DOI 10.1016/j.joca.2014.10.002
   Wang Y, 2015, ARTHRITIS RHEUMATOL, V67, P2141, DOI 10.1002/art.39182
   Witczak CA, 2008, CELL MOL LIFE SCI, V65, P3737, DOI 10.1007/s00018-008-8244-6
   Wong RJ, 2015, JAMA-J AM MED ASSOC, V314, P950, DOI 10.1001/jama.2015.8628
   Wu CL, 2015, ANN RHEUM DIS, V74, P2076, DOI 10.1136/annrheumdis-2014-205601
   Yamabe S, 2013, FEBS J, V280, P1617, DOI 10.1111/febs.12170
   Yoshimura N, 2012, OSTEOARTHR CARTILAGE, V20, P1217, DOI 10.1016/j.joca.2012.06.006
   Yoshimura N, 2011, J RHEUMATOL, V38, P921, DOI 10.3899/jrheum.100569
   Yusuf E, 2010, ANN RHEUM DIS, V69, P761, DOI 10.1136/ard.2008.106930
   Zhang KZ, 2006, NEUROLOGY, V66, pS102, DOI 10.1212/01.wnl.0000192306.98198.ec
   Zhao XL, 2014, ARTHRITIS RHEUMATOL, V66, P3073, DOI 10.1002/art.38791
   Zhuo Q, 2012, NAT REV RHEUMATOL, V8, P729, DOI 10.1038/nrrheum.2012.135
   Zignego DL, 2015, J BIOMECH, V48, P4253, DOI 10.1016/j.jbiomech.2015.10.038
NR 105
TC 62
Z9 69
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0736-0266
EI 1554-527X
J9 J ORTHOP RES
JI J. Orthop. Res.
PD DEC
PY 2016
VL 34
IS 12
BP 2048
EP 2058
DI 10.1002/jor.23420
PG 11
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA EI5LQ
UT WOS:000392536500004
PM 27605370
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Alosaimi, FD
   Abalhassan, MF
   Alhabbad, AA
   Fallata, EO
   Haddad, BA
   AlQattan, NI
   Alassiry, MZ
AF Alosaimi, Fahad D.
   Abalhassan, Mohammed F.
   Alhabbad, Abdulhadi A.
   Fallata, Ebtihaj O.
   Haddad, Bander A.
   AlQattan, Nada, I
   Alassiry, Mohammed Z.
TI Prevalence and determinants of physical activity in a mixed sample of
   psychiatric patients in Saudi Arabia
SO SAUDI MEDICAL JOURNAL
LA English
DT Article
ID SEVERE MENTAL-ILLNESS; SEDENTARY BEHAVIOR; METABOLIC SYNDROME; ANXIETY
   DISORDERS; BIPOLAR DISORDER; ALL-CAUSE; EXERCISE; DEPRESSION;
   ASSOCIATION; MORTALITY
AB Objectives: To estimate prevalence of physical activity and its associations with various psychiatric disorders and the use of psychotropic medications.
   Methods: A cross-sectional observational study was carried out between July 2012 and June 2014. Patients were enrolled from a number of hospitals located in 5 regions of the Kingdom of Saudi Arabia.
   Results: A total of 1185 patients were included in current analysis: 796 were outpatients, and 389 were inpatients. Out of 1,185 patients, 153 (12.9%) were physically active. Much higher rates of physical activity were reported among males than females (15.9% versus 9.6%, p<0.001). According to the univariate analysis, higher rates of physical activity were positively correlated with primary bipolar disorders, the use of antianxiety medications and, to a lesser extent, use of antipsychotic medications, but they were negatively correlated with primary anxiety disorders, use of antidepressant medications, and use of multiple psychotropic medications. The associations between physical activity and primary bipolar disorders (odds ratio [OR]=2.47, p=0.002), use of antianxiety medications (OR=3.58, p=0.003), and use of multiple psychotropic medications (OR=0.33, p<0.001) remained significant after adjusting for demographic and clinical characteristics.
   Conclusion: We report a variable but generally low prevalence of physical activity among a large, mixed sample of psychiatric patients in Saudi Arabia. These findings may highlight the importance of assessing physical activity status of psychiatric patients and the critical need for physical activity promotion programs among this group of disadvantaged patients.
C1 [Alosaimi, Fahad D.] King Saud Univ, Dept Psychiat, Riyadh, Saudi Arabia.
   [Haddad, Bander A.] Al Imam Mohammad Bin Saud Univ, Dept Neurosci, Riyadh, Saudi Arabia.
   [Abalhassan, Mohammed F.] Prince Sattam Bin Abdulaziz Univ, Dept Med, Alkharj, Saudi Arabia.
   [Alhabbad, Abdulhadi A.] Prince Mohammed Med City, Dept Psychiat, Aljoafi, Saudi Arabia.
   [Fallata, Ebtihaj O.] Mental Hlth Hosp, Dept Psychiat, Jeddah, Saudi Arabia.
   [Alassiry, Mohammed Z.] Mental Hlth Hosp, Dept Psychiat, Abha, Saudi Arabia.
   [AlQattan, Nada, I] Al Amal Complex Mental Hlth, Dept Psychiat, Dammam, Saudi Arabia.
C3 King Saud University; Imam Mohammad Ibn Saud Islamic University (IMSIU);
   Prince Sattam Bin Abdulaziz University; Prince Mohammed Medical City
RP Alosaimi, FD (corresponding author), King Saud Univ, Dept Psychiat, Riyadh, Saudi Arabia.
EM dr.fahad.alosaimi@gmail.com
RI Alosaimi, Fahad/JDW-3312-2023
OI Alosaimi, Fahad/0000-0003-1027-5836
FU College of Medicine Research Center, Deanship of Scientific Research,
   King Saud University
FX The authors extend their sincere appreciation for the support they
   received from the College of Medicine Research Center, Deanship of
   Scientific Research, King Saud University. The authors also express
   their gratitude to Ms. Fatima Jama and Dr. Aiman El-Saed for their
   assistance with data entry and analysis, respectively.
CR Al-Hazzaa HM, 2011, INT J BEHAV NUTR PHY, V8, DOI 10.1186/1479-5868-8-140
   Al-Nozha MM, 2007, SAUDI MED J, V28, P559
   Al-Nuaim AA, 2012, J NUTR METAB, V2012, DOI 10.1155/2012/417589
   Al-Zalabani AH, 2015, J TAIBAH UNIV MED SC, V10, P208, DOI 10.1016/j.jtumed.2014.11.001
   Alosaimi FD, 2017, GEN HOSP PSYCHIAT, V45, P62, DOI 10.1016/j.genhosppsych.2016.12.007
   Alosaimi FD, 2016, NEUROPSYCH DIS TREAT, V12, P897, DOI 10.2147/NDT.S100405
   Alsubaie ASR, 2015, INT J HEALTH SCI-IJH, V9, P400
   Amin TT, 2012, ASIAN PAC J CANCER P, V13, P351, DOI 10.7314/APJCP.2012.13.1.351
   Amin TT, 2011, J PHYS ACT HEALTH, V8, P775, DOI 10.1123/jpah.8.6.775
   [Anonymous], PHYS ACT AD
   [Anonymous], 2000, DIAGN STAT MAN MENT
   Carek PJ, 2011, INT J PSYCHIAT MED, V41, P15, DOI 10.2190/PM.41.1.c
   Centorrino F, 2012, HUM PSYCHOPHARM CLIN, V27, P521, DOI 10.1002/hup.2257
   Choong E, 2012, J PSYCHIATR RES, V46, P540, DOI 10.1016/j.jpsychires.2012.01.014
   Chuang HT, 2008, CAN J PSYCHIAT, V53, P260, DOI 10.1177/070674370805300407
   Chwastiak LA, 2011, PSYCHOSOMATICS, V52, P230, DOI 10.1016/j.psym.2010.12.009
   de Wit LM, 2010, DEPRESS ANXIETY, V27, P1057, DOI 10.1002/da.20738
   Eijsvogels TMH, 2015, JAMA-J AM MED ASSOC, V314, P1915, DOI 10.1001/jama.2015.10858
   Hales RE, 2008, AM J PSYCHIAT, V165, P1220
   Harvey SB, 2010, BRIT J PSYCHIAT, V197, P357, DOI 10.1192/bjp.bp.109.075176
   Hupin D, 2015, BRIT J SPORT MED, V49, DOI 10.1136/bjsports-2014-094306
   Janney CA, 2014, J AFFECT DISORDERS, V152, P498, DOI 10.1016/j.jad.2013.09.009
   Knöchel C, 2012, PROG NEUROBIOL, V96, P46, DOI 10.1016/j.pneurobio.2011.11.007
   Koenig HG, 2013, INT J PSYCHIAT MED, V46, P223, DOI 10.2190/PM.46.3.a
   Kyu HH, 2016, BMJ-BRIT MED J, V354, DOI 10.1136/bmj.i3857
   Mabry R, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-3642-4
   Mammen G, 2013, AM J PREV MED, V45, P649, DOI 10.1016/j.amepre.2013.08.001
   Mangerud WL, 2014, CHILD ADOL PSYCH MEN, V8, DOI 10.1186/1753-2000-8-2
   McDevitt J, 2006, J NURS SCHOLARSHIP, V38, P50, DOI 10.1111/j.1547-5069.2006.00077.x
   Min JA, 2013, QUAL LIFE RES, V22, P231, DOI 10.1007/s11136-012-0153-3
   Nocon M, 2008, EUR J CARDIOV PREV R, V15, P239, DOI 10.1097/HJR.0b013e3282f55e09
   Nyboe L, 2013, NORD J PSYCHIAT, V67, P43, DOI 10.3109/08039488.2012.675588
   Osborn DPJ, 2007, ARCH GEN PSYCHIAT, V64, P242, DOI 10.1001/archpsyc.64.2.242
   Pasco JA, 2011, INT PSYCHOGERIATR, V23, P292, DOI 10.1017/S1041610210001833
   Rebar AL, 2015, HEALTH PSYCHOL REV, V9, P366, DOI 10.1080/17437199.2015.1022901
   Richardson CR, 2005, PSYCHIAT SERV, V56, P324, DOI 10.1176/appi.ps.56.3.324
   Rocha Saulo Vasconcelos, 2012, Rev. bras. epidemiol., V15, P871, DOI 10.1590/S1415-790X2012000400017
   Ross R, 2015, ANN INTERN MED, V162, P325, DOI 10.7326/M14-1189
   Saudi Ministry of Health, 2005, WHO STEPWISE APPR NC
   Ströhle A, 2009, J NEURAL TRANSM, V116, P777, DOI 10.1007/s00702-008-0092-x
   Stubbs B, 2016, J AFFECT DISORDERS, V190, P457, DOI 10.1016/j.jad.2015.10.019
   Sylvia LG, 2013, J AFFECT DISORDERS, V151, P722, DOI 10.1016/j.jad.2013.07.031
   Ussher M, 2007, PSYCHIAT SERV, V58, P405, DOI 10.1176/appi.ps.58.3.405
   Vancampfort D, 2016, J AFFECT DISORDERS, V201, P145, DOI 10.1016/j.jad.2016.05.020
   Vancampfort D, 2016, GEN HOSP PSYCHIAT, V39, P15, DOI 10.1016/j.genhosppsych.2015.11.008
   Vancampfort D, 2013, PSYCHIAT RES, V207, P25, DOI 10.1016/j.psychres.2012.09.026
   Walker ER, 2015, JAMA PSYCHIAT, V72, P334, DOI 10.1001/jamapsychiatry.2014.2502
   Wee CC, 1999, JAMA-J AM MED ASSOC, V282, P1583, DOI 10.1001/jama.282.16.1583
   Woodcock J, 2011, INT J EPIDEMIOL, V40, P121, DOI 10.1093/ije/dyq104
   Zechner MR, 2016, PSYCHIATR REHABIL J, V39, P321, DOI 10.1037/prj0000191
NR 50
TC 5
Z9 5
U1 0
U2 5
PU SAUDI MED J
PI RIYADH
PA ARMED FORCES HOSPITAL, PO BOX 7897,, RIYADH 11159, SAUDI ARABIA
SN 0379-5284
J9 SAUDI MED J
JI Saudi Med. J.
PD APR
PY 2018
VL 39
IS 4
BP 400
EP 410
DI 10.15537/smj.2018.4.21796
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA GQ0PT
UT WOS:000441322400012
PM 29619493
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Matsuura, N
   Asano, C
   Nagasawa, K
   Ito, S
   Sano, Y
   Minagawa, Y
   Yamada, Y
   Hattori, T
   Watanabe, S
   Murohara, T
   Nagata, K
AF Matsuura, Natsumi
   Asano, Chiharu
   Nagasawa, Kai
   Ito, Shogo
   Sano, Yusuke
   Minagawa, Yuji
   Yamada, Yuichiro
   Hattori, Takuya
   Watanabe, Shogo
   Murohara, Toyoaki
   Nagata, Kohzo
TI Effects of pioglitazone on cardiac and adipose tissue pathology in rats
   with metabolic syndrome
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Metabolic syndrome; Thiazolidinedione; Cardiac remodeling; Inflammation;
   Adipose tissue; Glucose metabolism
ID NECROSIS-FACTOR-ALPHA; ACTIVATED PROTEIN-KINASE; HEART-FAILURE;
   INSULIN-RESISTANCE; ANIMAL-MODEL; DAHLS.Z-LEPR(FA)/LEPR(FA) RATS;
   OXIDATIVE STRESS; GENE-EXPRESSION; NADPH OXIDASE; FOOD-INTAKE
AB Background: Pioglitazone is a thiazolidinedione drug that acts as an insulin sensitizer. We recently characterized DahlS. Z-Lepr(fa)/Lepr(fa) (DS/obese) rats, derived from a cross between Dahl salt-sensitive and Zucker rats, as a new animal model of metabolic syndrome. We have now investigated the effects of pioglitazone on cardiac and adipose tissue pathology in this model.
   Methods and results: DS/obese rats were treated with pioglitazone (2.5 mg/kg per day, per os) from 9 to 13 weeks of age. Age-matched homozygous lean (DahlS. Z-Lepr(+)/Lepr(+), or DS/lean) littermates served as controls. Pioglitazone increased body weight and food intake in DS/obese rats. It also ameliorated left ventricular (LV) hypertrophy, fibrosis, and diastolic dysfunction as well as attenuated cardiac oxidative stress and inflammation, without lowering blood pressure, in DS/obese rats, but it had no effect on these parameters in DS/lean rats. In addition, pioglitazone increased visceral and subcutaneous fat mass but alleviated adipocyte hypertrophy and inflammation in visceral adipose tissue in DS/obese rats. Furthermore, pioglitazone increased the serum concentration of adiponectin, induced activation of AMP-activated protein kinase (AMPK) in the heart, as well as ameliorated glucose intolerance and insulin resistance in DS/obese rats.
   Conclusions: Treatment of DS/obese rats with pioglitazone exacerbated obesity but attenuated LV hypertrophy, fibrosis, and diastolic dysfunction, with these latter effects being associated with the activation of cardiac AMPK signaling likely as a result of the stimulation of adiponectin secretion. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Matsuura, Natsumi; Nagasawa, Kai; Ito, Shogo; Sano, Yusuke; Yamada, Yuichiro; Hattori, Takuya; Watanabe, Shogo; Nagata, Kohzo] Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Nagoya, Aichi 4618673, Japan.
   [Asano, Chiharu; Minagawa, Yuji] Nagoya Univ, Sch Hlth Sci, Dept Med Technol, Nagoya, Aichi 4618673, Japan.
   [Murohara, Toyoaki] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi 4618673, Japan.
C3 Nagoya University; Nagoya University; Nagoya University
RP Nagata, K (corresponding author), Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Higashi Ku, 1-1-20 Daikominami, Nagoya, Aichi 4618673, Japan.
EM nagata@met.nagoya-u.ac.jp
RI Murohara, Toyoaki/M-4958-2014
FU Kyowa Hakko Kirin Co. Ltd. (Tokyo, Japan); Ajinomoto Pharmaceuticals
   Co., Ltd. (Tokyo, Japan); Astellas Pharma Inc. (Tokyo, Japan); Mochida
   Pharmaceutical Co., Ltd. (Tokyo, Japan); Mitsubishi Tanabe Pharma
   Corporation (Osaka, Japan); Takeda Pharmaceutical Company Limited
   (Osaka, Japan); Daiichi-Sankyo Company, Limited (Tokyo, Japan); Japanese
   government
FX This study was supported by unrestricted research grants from Kyowa
   Hakko Kirin Co. Ltd. (Tokyo, Japan), Ajinomoto Pharmaceuticals Co., Ltd.
   (Tokyo, Japan), Astellas Pharma Inc. (Tokyo, Japan), Mochida
   Pharmaceutical Co., Ltd. (Tokyo, Japan), Mitsubishi Tanabe Pharma
   Corporation (Osaka, Japan), Takeda Pharmaceutical Company Limited
   (Osaka, Japan), Daiichi-Sankyo Company, Limited (Tokyo, Japan) and Dr.
   Nagata (Nagoya University) as well as by Management Expenses Grants from
   the Japanese government to Nagoya University.
CR Ahmed MS, 2004, J MOL CELL CARDIOL, V36, P393, DOI 10.1016/j.yjmcc.2003.12.004
   Berger J, 2002, ANNU REV MED, V53, P409, DOI 10.1146/annurev.med.53.082901.104018
   Boustany CM, 2004, AM J PHYSIOL-REG I, V287, pR943, DOI 10.1152/ajpregu.00265.2004
   Dentali F, 2009, SEMIN THROMB HEMOST, V35, P451, DOI 10.1055/s-0029-1234140
   DRYDEN S, 1994, EUR J CLIN INVEST, V24, P293, DOI 10.1111/j.1365-2362.1994.tb01089.x
   Elmarakby AA, 2005, HYPERTENSION, V45, P283, DOI 10.1161/01.HYP.0000153051.56460.6a
   Fujioka D, 2006, AM J PHYSIOL-HEART C, V290, pH2409, DOI 10.1152/ajpheart.00987.2005
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Guan YF, 2005, NAT MED, V11, P861, DOI 10.1038/nm1278
   Hallakou S, 1997, DIABETES, V46, P1393, DOI 10.2337/diabetes.46.9.1393
   Hattori T, 2011, NUTR DIABETES, V1, DOI 10.1038/nutd.2010.1
   HOFMANN C, 1994, ENDOCRINOLOGY, V134, P264, DOI 10.1210/en.134.1.264
   Hopkins TA, 2007, CARDIOVASC RES, V74, P11, DOI 10.1016/j.cardiores.2006.10.009
   Horman S, 2006, J BIOL CHEM, V281, P5335, DOI 10.1074/jbc.M506850200
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   HOTAMISLIGIL GS, 1994, P NATL ACAD SCI USA, V91, P4854, DOI 10.1073/pnas.91.11.4854
   Kadowaki T, 2005, ENDOCR REV, V26, P439, DOI 10.1210/er.2005-0005
   Kajimura S, 2010, CELL METAB, V11, P257, DOI 10.1016/j.cmet.2010.03.005
   Kato MF, 2008, J HYPERTENS, V26, P1669, DOI 10.1097/HJH.0b013e328302f0f7
   Kudoh A, 2011, LIFE SCI, V88, P1055, DOI 10.1016/j.lfs.2011.04.001
   LeBrasseur NK, 2006, AM J PHYSIOL-ENDOC M, V291, pE175, DOI 10.1152/ajpendo.00453.2005
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Miles PDG, 1997, DIABETES, V46, P1678, DOI 10.2337/diabetes.46.11.1678
   Minokoshi Y, 2004, NATURE, V428, P569, DOI 10.1038/nature02440
   Miyachi M, 2009, HYPERTENSION, V53, P701, DOI 10.1161/HYPERTENSIONAHA.108.127290
   Miyata K, 2005, J AM SOC NEPHROL, V16, P2906, DOI 10.1681/ASN.2005040390
   Murase T, 2012, HYPERTENSION, V59, P694, DOI 10.1161/HYPERTENSIONAHA.111.180976
   Murase T, 2012, HYPERTENS RES, V35, P186, DOI 10.1038/hr.2011.157
   Nagata K, 2006, HYPERTENSION, V47, P656, DOI 10.1161/01.HYP.0000203772.78696.67
   Nagata K, 2002, HYPERTENSION, V40, P168, DOI 10.1161/01.HYP.0000026668.50222.1E
   NAGATA K, 1995, J AM COLL CARDIOL, V25, P295, DOI 10.1016/0735-1097(94)00369-2
   Oana F, 2005, METABOLISM, V54, P995, DOI 10.1016/j.metabol.2005.02.016
   Ohno H, 2012, CELL METAB, V15, P395, DOI 10.1016/j.cmet.2012.01.019
   Okuno A, 1998, J CLIN INVEST, V101, P1354, DOI 10.1172/JCI1235
   Peraldi P, 1997, J CLIN INVEST, V100, P1863, DOI 10.1172/JCI119715
   Permana PA, 2009, AM J PHYSIOL-ENDOC M, V296, pE1076, DOI 10.1152/ajpendo.91013.2008
   Rasouli N, 2012, PHARMACOGENET GENOM, V22, P484, DOI 10.1097/FPC.0b013e328352a72e
   Rose AJ, 2010, J STEROID BIOCHEM, V122, P10, DOI 10.1016/j.jsbmb.2010.02.010
   SAHN DJ, 1978, CIRCULATION, V58, P1072, DOI 10.1161/01.CIR.58.6.1072
   Saitoh Y, 2007, DIABETES RES CLIN PR, V77, P351, DOI 10.1016/j.diabres.2007.01.016
   Sakata Y, 2004, CIRCULATION, V109, P2143, DOI 10.1161/01.CIR.0000125741.88712.77
   Sales CH, 2014, CLIN NUTR, V33, P879, DOI 10.1016/j.clnu.2013.10.004
   Samuelsson AM, 2006, AM J PHYSIOL-HEART C, V291, pH787, DOI 10.1152/ajpheart.00974.2005
   SCHWARTZ MW, 1992, ENDOCR REV, V13, P387, DOI 10.1210/er.13.3.387
   Shi H, 2006, J CLIN INVEST, V116, P3015, DOI 10.1172/JCI28898
   Shibata R, 2009, CIRC J, V73, P608, DOI 10.1253/circj.CJ-09-0057
   Staab CA, 2010, J STEROID BIOCHEM, V119, P56, DOI 10.1016/j.jsbmb.2009.12.013
   STRACK AM, 1995, AM J PHYSIOL-REG I, V268, pR142, DOI 10.1152/ajpregu.1995.268.1.R142
   Takahashi K, 2003, J BIOL CHEM, V278, P46654, DOI 10.1074/jbc.M309895200
   Tiikkainen M, 2004, DIABETES, V53, P2169, DOI 10.2337/diabetes.53.8.2169
   Usukura M, 2009, STEROIDS, V74, P978, DOI 10.1016/j.steroids.2009.07.006
   Xu JL, 2005, HYPERTENSION, V46, P719, DOI 10.1161/01.HYP.0000185189.46698.15
   Yamada T, 2009, EUR J PHARMACOL, V615, P163, DOI 10.1016/j.ejphar.2009.05.028
   Zhang P, 2008, HYPERTENSION, V52, P918, DOI 10.1161/HYPERTENSIONAHA.108.114702
NR 54
TC 41
Z9 42
U1 1
U2 9
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD JAN 20
PY 2015
VL 179
BP 360
EP 369
DI 10.1016/j.ijcard.2014.11.099
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AW2AC
UT WOS:000346089400099
PM 25464487
DA 2025-06-11
ER

PT J
AU Bradley, R
   Fitzpatrick, AL
   Jenny, NS
   Lee, DH
   Jacobs, DR
AF Bradley, Ryan
   Fitzpatrick, Annette L.
   Jenny, Nancy S.
   Lee, Duk-Hee
   Jacobs, David R., Jr.
TI Associations between total serum GGT activity and metabolic risk: MESA
SO BIOMARKERS IN MEDICINE
LA English
DT Article
DE gamma-glutamyltransferase; GGT; glutathione; metabolic syndrome;
   oxidative stress; Type 2 diabetes
ID GAMMA-GLUTAMYL-TRANSFERASE; OXIDATIVE STRESS; ALANINE AMINOTRANSFERASE;
   INSULIN-RESISTANCE; HEALTHY-MEN; BETA-CELL; PLASMA; HEART;
   TRANSPEPTIDASE; GLUTATHIONE
AB Aim: To evaluate associations between total serum GGT activity, metabolic risk factors and prevalent metabolic disease in MESA. Patients & methods: Continuous associations between GGT and fasting blood glucose (FBG), fasting insulin, HbA(1c) and Homeostasis Model Assessment Index of Insulin Resistance (HOMA-IR) were evaluated in the entire MESA cohort and in metabolic disease subgroups using linear regression models incrementally adjusted for age, gender, site, race, lifestyle, traditional risk factors and medications. Cross-sectional odds of prevalent impaired FBG, metabolic syndrome and Type 2 diabetes were calculated for GGT quintiles in the entire cohort and in subgroups defined by age (< or 65 years) and ethnicity. Results: In multivariable models, significant associations were present between GGT activity and FBG, fasting insulin, HbA(1c) and HOMA-IR, with the interaction between GGT and BMI affecting the association between GGT and HOMA-IR as well as the association between BMI and HOMA-IR (p < 0.0001). Adjusted odds ratios (95% CIs) of prevalent impaired FBG, metabolic syndrome and Type 2 diabetes for quintile 5 versus 1 in the entire cohort were 2.4 (1.7-3.5), 3.3 (2.5-4.5) and 2.8 (1.8-4.4), respectively (p < 0.0001). GGT associations weakened with age. The significance of linear trends for increased prevalent metabolic disease by increasing GGT quintile varied by ethnicity. Conclusion: GGT is strongly associated with both cardiovascular and metabolic risk factors, including prevalent metabolic disease, in the MESA cohort.
C1 [Bradley, Ryan] Bastyr Univ, Res Inst, San Diego, CA 92121 USA.
   [Fitzpatrick, Annette L.] Univ Washington, Seattle, WA 98155 USA.
   [Jenny, Nancy S.] Univ Vermont, Coll Med, Lab Clin Biochem Res, Colchester, VT 05446 USA.
   [Lee, Duk-Hee] Kyungpook Natl Univ, Sch Med, Taegu 700842, South Korea.
   [Jacobs, David R., Jr.] Univ Minnesota, Div Epidemiol & Community Hlth, Minneapolis, MN 55454 USA.
C3 University of Washington; University of Washington Seattle; University
   of Vermont; Kyungpook National University (KNU); University of Minnesota
   System; University of Minnesota Twin Cities
RP Bradley, R (corresponding author), Bastyr Univ, Res Inst, 4106 Sorrento Valley Blvd, San Diego, CA 92121 USA.
EM rbradley@bastyr.edu
RI Jacobs, David/G-5405-2011
OI Jacobs, David/0000-0002-7232-0543
FU National Heart, Lung and Blood Institute [N01-HC-95159-95166]; National
   Center for Research Resources [1KL2RR025015]
FX This research was made possible by contracts N01-HC-95159-95166 from the
   National Heart, Lung and Blood Institute, and 1KL2RR025015 from the
   National Center for Research Resources. The authors have no other
   relevant affiliations or financial involvement with any organization or
   entity with a financial interest in or financial conflict with the
   subject matter or materials discussed in the manuscript apart from those
   disclosed.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   André P, 2006, DIABETOLOGIA, V49, P2599, DOI 10.1007/s00125-006-0418-x
   [Anonymous], 2012, DIABETES CARE, V35, pS11, DOI [10.2337/dc35-S011, 10.2337/dc12-s004]
   Bild DE, 2002, AM J EPIDEMIOL, V156, P871, DOI 10.1093/aje/kwf113
   Bonnet F, 2011, DIABETES, V60, P1660, DOI 10.2337/db10-1806
   BRAIDE S A, 1989, Journal of Environmental Pathology Toxicology and Oncology, V9, P429
   Brownlee M, 2005, DIABETES, V54, P1615, DOI 10.2337/diabetes.54.6.1615
   Chévez-Barrios P, 2000, EXP EYE RES, V71, P575, DOI 10.1006/exer.2000.0913
   Dickinson DA, 2002, ANN NY ACAD SCI, V973, P488, DOI 10.1111/j.1749-6632.2002.tb04690.x
   Evans JL, 2002, ENDOCR REV, V23, P599, DOI 10.1210/er.2001-0039
   Franzini M, 2008, ANAL BIOCHEM, V374, P1, DOI 10.1016/j.ab.2007.10.025
   Franzini M, 2013, CLIN CHIM ACTA, V417, P19, DOI 10.1016/j.cca.2012.12.002
   Franzini M, 2013, DRUG ALCOHOL DEPEN, V127, P239, DOI 10.1016/j.drugalcdep.2012.06.004
   Franzini M, 2012, LIVER INT, V32, P629, DOI 10.1111/j.1478-3231.2011.02673.x
   Franzini M, 2009, BIOMARKERS, V14, P486, DOI 10.3109/13547500903093757
   Fraser A, 2007, ARTERIOSCL THROM VAS, V27, P2729, DOI 10.1161/ATVBAHA.107.152298
   Fraser A, 2009, DIABETES CARE, V32, P741, DOI 10.2337/dc08-1870
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Huseby NE, 2003, FREE RADICAL RES, V37, P99, DOI 10.1080/1071576021000036434
   Lee DH, 2004, AM J CLIN NUTR, V79, P600
   Lee DH, 2009, EUR J CARDIOV PREV R, V16, P16, DOI 10.1097/HJR.0b013e32830aba5c
   Lee DH, 2009, FREE RADICAL RES, V43, P533, DOI 10.1080/10715760902893324
   Lim JS, 2007, CLIN CHEM, V53, P1092, DOI 10.1373/clinchem.2006.079814
   Lim JS, 2004, FREE RADICAL BIO MED, V37, P1018, DOI 10.1016/j.freeradbiomed.2004.06.032
   Liu CF, 2012, INT J CLIN PRACT, V66, P692, DOI 10.1111/j.1742-1241.2012.02959.x
   Liu CF, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048878
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mayne ST, 2003, J NUTR, V133, p933S, DOI 10.1093/jn/133.3.933S
   Meisinger C, 2006, ATHEROSCLEROSIS, V189, P297, DOI 10.1016/j.atherosclerosis.2006.01.010
   Meisinger C, 2005, J INTERN MED, V258, P527, DOI 10.1111/j.1365-2796.2005.01572.x
   Onat A, 2012, OBESITY, V20, P842, DOI 10.1038/oby.2011.136
   Paolicchi A, 2006, ATHEROSCLEROSIS, V186, P80, DOI 10.1016/j.atherosclerosis.2005.07.012
   Nguyen QM, 2011, DIABETES CARE, V34, P2603, DOI 10.2337/dc11-0919
   Ravuri C, 2011, FREE RADICAL RES, V45, P600, DOI 10.3109/10715762.2011.564164
   Robertson RP, 2007, CELL BIOCHEM BIOPHYS, V48, P139, DOI 10.1007/s12013-007-0026-5
   Ruhl CE, 2009, GASTROENTEROLOGY, V136, P477, DOI 10.1053/j.gastro.2008.10.052
   SATOH T, 1980, RES COMMUN CHEM PATH, V30, P151
   Sedda V, 2008, FREE RADICAL RES, V42, P135, DOI 10.1080/10715760701836821
   SELINGER MJ, 1982, CLIN CHIM ACTA, V125, P283, DOI 10.1016/0009-8981(82)90258-3
   SILBER PM, 1986, ANAL BIOCHEM, V158, P68, DOI 10.1016/0003-2697(86)90590-7
   Wannamethee SG, 2012, ARTERIOSCL THROM VAS, V32, P830, DOI 10.1161/ATVBAHA.111.240457
   Whitfield JB, 2001, CRIT REV CL LAB SCI, V38, P263, DOI 10.1080/20014091084227
   Will Y, 2000, HEPATOLOGY, V32, P740, DOI 10.1053/jhep.2000.17913
NR 43
TC 24
Z9 27
U1 1
U2 16
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1752-0363
EI 1752-0371
J9 BIOMARK MED
JI Biomark. Med.
PD OCT
PY 2013
VL 7
IS 5
BP 709
EP 721
DI 10.2217/bmm.13.71
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 219AF
UT WOS:000324474800011
PM 24044563
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Li, N
   Wang, R
   Hu, PH
   Lu, WT
   Zhao, XC
   Wang, L
   Song, M
   Gao, YY
   An, CX
   Bashir, S
   Wang, XY
AF Li, Na
   Wang, Ran
   Hu, Peihua
   Lu, Wenting
   Zhao, Xiaochuan
   Wang, Lan
   Song, Mei
   Gao, Yuanyuan
   An, Cuixia
   Bashir, Shahid
   Wang, Xueyi
TI Effect of night shift work on metabolic syndrome in adults who suffered
   from earthquake stress in early life
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE pregnancy; infancy; earthquake stress; metabolic syndrome; night shift
   work; adulthood
ID PREVALENCE
AB ObjectiveTo examine the role of night shift work on the risk of metabolic syndrome (MetS) in adults suffered from earthquakes prenatally or as infants and to analyse the effect of stress on factors that influence MetS in this population. MethodsWe included 870 subjects from 2014 to 2015. All subjects work as miners for the Kailuan Mining Group and were born were living in Tangshan. Participants were classified into two groups on basis of their work schedules: day shift and night shift. They were further classified into the prenatal exposure group, the infancy exposure group, and the control group based on their age during the Tangshan earthquake. This study was conducted 38 years after the earthquake. Participants' general demographic data, smoking and drinking habits, as well as work schedules were collected. All participants' sleep status was assessed with the Pittsburgh Sleep Quality Index. The measurement of all subjects' waist circumference and blood pressure was made, and triglycerides, fasting blood glucose, high-density lipoproteins, and low-density lipoproteins were measured by collecting blood samples. The definition of MetS was made after the guidelines for preventing and controlling type 2 diabetes in China (2017 Edition). ResultsA total of 187 (21.5%) workers were determined to have MetS. The incidence of MetS was greatly higher in night shift workers who were exposed to an earthquake during infancy than in day shift workers (& chi;(2) = 8.053, p = 0.005). A multivariate logistic regression analysis displayed male participants had a higher risk develop MetS than female participants (p = 0.042, OR = 0.368, 95% CI = 0.140, 0.965). Current smokers (p = 0.030, OR = 1.520, 95%CI = 1.042, 2.218) and participants who sleep fewer than 7 h per night (p = 0.015, OR = 1.638, 95%CI = 1.101, 2.437) had a higher risk of MetS. Prenatal earthquake stress was also a risk element for MetS (p = 0.012, OR = 1.644, 95%CI = 1.115, 2.423). ConclusionThe risk of MetS is significantly higher in night shift workers exposed to earthquake stress during infancy than day shift workers. Earthquake exposure during pregnancy is an independent risk factor for MetS. Smoking and sleeping less than 7 h have a higher risk of MetS than the control group.
C1 [Li, Na; Wang, Ran; Hu, Peihua; Lu, Wenting; Zhao, Xiaochuan; Wang, Lan; Song, Mei; Gao, Yuanyuan; An, Cuixia; Wang, Xueyi] Hebei Med Univ, Hosp 1, Dept Psychiat, Shijiazhuang, Peoples R China.
   [Li, Na; Wang, Ran; Hu, Peihua; Lu, Wenting; Zhao, Xiaochuan; Wang, Lan; Song, Mei; Gao, Yuanyuan; An, Cuixia; Wang, Xueyi] Hebei Med Univ, Mental Hlth Ctr, Shijiazhuang, Peoples R China.
   [Li, Na; Wang, Ran; Hu, Peihua; Lu, Wenting; Zhao, Xiaochuan; Wang, Lan; Song, Mei; Gao, Yuanyuan; An, Cuixia; Wang, Xueyi] Clin Med Res Ctr Psychiat & Psychol Disorders Hebe, Shijiazhuang, Peoples R China.
   [Bashir, Shahid] King Fahad Specialist Hosp, Saudi Arabia Neurosci Ctr, Dammam, Saudi Arabia.
C3 Hebei Medical University; Hebei Medical University
RP Wang, XY (corresponding author), Hebei Med Univ, Hosp 1, Dept Psychiat, Shijiazhuang, Peoples R China.; Wang, XY (corresponding author), Hebei Med Univ, Mental Hlth Ctr, Shijiazhuang, Peoples R China.; Wang, XY (corresponding author), Clin Med Res Ctr Psychiat & Psychol Disorders Hebe, Shijiazhuang, Peoples R China.
EM ydyywxy@163.com
RI Bashir, Shahid/AFC-6566-2022; gao, yuanyuan/GSE-5627-2022; han,
   wei/ABG-2691-2021; Wang, Ran/GRX-9114-2022; Bashir, Shahid/HOA-8856-2023
OI Bashir, Shahid/0000-0001-6286-6895
FU Samp;T Program of Hebei [SG2021189]; Project of Clinical Medical
   Research Center for Psychiatric and Psychological Disorders of Hebei
   Province [199776245D]; Provincial Science and Technology Program of
   Hebei Province [21377711D]; Hebei Medical University Clinical Research
   Innovation Team [2022LCTD-A1]; Introduce Foreign Intellectual Projects
   of Finance Department in Hebei Province [YZ202204]; Medical Research
   Projects from Health Commission of Hebei Province [20210418]
FX This study was supported by the S & amp;T Program of Hebei (SG2021189),
   Project of Clinical Medical Research Center for Psychiatric and
   Psychological Disorders of Hebei Province (199776245D), Provincial
   Science and Technology Program of Hebei Province (21377711D), Hebei
   Medical University Clinical Research Innovation Team (2022LCTD-A1) and
   Introduce Foreign Intellectual Projects of Finance Department in Hebei
   Province (YZ202204). Medical Research Projects from Health Commission of
   Hebei Province (20210418).
CR An CX, 2014, INT J CLIN EXP MED, V7, P4441
   Bayon V, 2022, BMJ OPEN, V12, DOI 10.1136/bmjopen-2021-053591
   Boisvenue JJ, 2023, METAB SYNDR RELAT D, V21, P133, DOI 10.1089/met.2022.0065
   Bunea IM, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/s41398-017-0032-3
   Burgueño AL, 2020, INT J OBESITY, V44, P1, DOI 10.1038/s41366-019-0423-z
   Cheng WJ, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0261349
   [中华医学会糖尿病学分会 Chinese Diabetes Society], 2018, [中国实用内科杂志, Chinese Journal of Practical Internal Medicine], V38, P292
   Cho SH, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-07626-1
   Cristofori F, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.578386
   Delpierre C, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-3484-0
   Doom JR, 2019, J PEDIATR-US, V209, P85, DOI 10.1016/j.jpeds.2019.01.058
   Du R, 2020, J AM HEART ASSOC, V9, DOI 10.1161/JAHA.119.014175
   Godoy LC, 2021, JAMA CARDIOL, V6, P228, DOI 10.1001/jamacardio.2020.6050
   Grilo LF, 2021, EUR J CLIN INVEST, V51, DOI 10.1111/eci.13625
   Hanlon EC, 2016, SLEEP, V39, P653, DOI 10.5665/sleep.5546
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Hsu CN, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222111872
   Huang ZG, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.857985
   Kazemi M, 2023, DIABETOL METAB SYNDR, V15, DOI 10.1186/s13098-023-01072-3
   Li CH, 2019, NAT REV ENDOCRINOL, V15, P313, DOI 10.1038/s41574-019-0195-5
   Li N, 2020, J CLIN HYPERTENS, V22, P2354, DOI 10.1111/jch.14083
   Ljevak I, 2021, ACTA CLIN CROAT, V60, P476, DOI 10.20471/acc.2021.60.03.19
   Mavrouli M, 2023, MICROORGANISMS, V11, DOI 10.3390/microorganisms11020419
   Mosavat M, 2021, OBESITY FACTS, V14, P214, DOI 10.1159/000514095
   Nobile S, 2022, J PERS MED, V12, DOI 10.3390/jpm12020157
   O'Connor DB, 2021, ANNU REV PSYCHOL, V72, P663, DOI 10.1146/annurev-psych-062520-122331
   Park EJ, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19094949
   Poplawski J, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-69866-3
   Possamai-Della T, 2023, MOL NEUROBIOL, V60, P5013, DOI 10.1007/s12035-023-03348-1
   Primack C, 2021, NURS CLIN N AM, V56, P565, DOI 10.1016/j.cnur.2021.07.012
   Reutrakul S, 2018, METABOLISM, V84, P56, DOI 10.1016/j.metabol.2018.02.010
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Schulz LC, 2010, P NATL ACAD SCI USA, V107, P16757, DOI 10.1073/pnas.1012911107
   Stoccoro A, 2023, GENES-BASEL, V14, DOI 10.3390/genes14040836
   Takahashi Shuko, 2020, Metabol Open, V7, P100042, DOI 10.1016/j.metop.2020.100042
   van Egmond LT, 2023, OBESITY, V31, P635, DOI 10.1002/oby.23616
   Wang ZH, 2019, EUR J CLIN NUTR, V73, P724, DOI 10.1038/s41430-018-0211-1
   Wei ZK, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23031706
   Yao F, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124475
   Yatsunenko T, 2012, NATURE, V486, P222, DOI 10.1038/nature11053
   Zarocostas John, 2010, BMJ, V341, pc7065, DOI 10.1136/bmj.c7065
NR 41
TC 0
Z9 0
U1 1
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD JUL 20
PY 2023
VL 11
AR 1139113
DI 10.3389/fpubh.2023.1139113
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA O1SO2
UT WOS:001041690000001
PM 37546325
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Liva, K
   Panagiotopoulos, AA
   Foscolou, A
   Amerikanou, C
   Vitali, A
   Zioulis, S
   Argyri, K
   Panoutsopoulos, GI
   Kaliora, AC
   Gioxari, A
AF Liva, Konstantina
   Panagiotopoulos, Athanasios A.
   Foscolou, Alexandra
   Amerikanou, Charalampia
   Vitali, Alkistis
   Zioulis, Stavros
   Argyri, Konstantina
   Panoutsopoulos, Georgios I.
   Kaliora, Andriana C.
   Gioxari, Aristea
TI High Polyphenol Extra Virgin Olive Oil and Metabolically Unhealthy
   Obesity: A Scoping Review of Preclinical Data and Clinical Trials
SO CLINICS AND PRACTICE
LA English
DT Review
DE extra virgin olive oil; polyphenols; obesity; metabolic syndrome;
   hydroxytyrosol; tyrosol; oxidative stress; inflammation
ID PHENOLIC-COMPOUNDS; LIPID PROFILE; GLOBAL BURDEN; OLEIC-ACID; RICH;
   SUPPLEMENTATION; CONSUMPTION; LIVER; DIET
AB Background/Objectives: During the last decade, there has been an increased interest in phenolic compound-rich natural products as natural therapies for regulating the molecular pathways behind central obesity and associated metabolic disorders. The present scoping review presents the outcomes of clinical and preclinical studies examining the anti-obesity effects of high phenolic extra virgin olive oil (HP-EVOO) and its possible underlying molecular mechanisms. Methods: Studies published between 2014 and 2024 were searched via MEDLINE, Scopus, Cochrane, the Web of Science, Semantic Scholar, Google Scholar, Science.gov, and Clinicaltrials.gov databases. A combination of keywords and Boolean logic was used to search throughout the last decade in all databases, including "hyperglycemia" or "hypertension" or "metabolic syndrome" or "dyslipidemia" or "hyperlipidemia" or "hypoglycemia" or "obesity" or "macrovascular diabetic complications" or "microvascular diabetic complications" or "cardiovascular disease" or "overweight" or "insulin sensitivity" or "insulin resistance" and "extra virgin olive oil" or "high phenolic olive oil" and "human" or "animal model". Results: The 10-year literature survey identified 21 studies in both animal models and humans, indicating that HP-EVOO improves inflammation, glycemic control, oxidative stress and endothelial function, potentially protecting against metabolic syndrome, hypertension and type 2 diabetes, even compared to EVOO. Moreover, HP-EVOO's antiplatelet effect and improvement in HDL functionality reduce cardiovascular risk. Conclusions: The evidence presented in this study demonstrates that HP-EVOO represents an effective preventive and therapeutic dietary approach to cardiometabolic diseases.
C1 [Liva, Konstantina; Panagiotopoulos, Athanasios A.; Foscolou, Alexandra; Vitali, Alkistis; Zioulis, Stavros; Argyri, Konstantina; Panoutsopoulos, Georgios I.; Gioxari, Aristea] Univ Peloponnese, Sch Hlth Sci, Dept Nutr Sci & Dietet, Antikalamos 24100, Kalamata, Greece.
   [Amerikanou, Charalampia; Kaliora, Andriana C.] Harokopio Univ, Sch Hlth Sci & Educ, Dept Dietet & Nutr Sci, 70 El Venizelou Ave, Athens 17676, Greece.
C3 Harokopio University Athens
RP Gioxari, A (corresponding author), Univ Peloponnese, Sch Hlth Sci, Dept Nutr Sci & Dietet, Antikalamos 24100, Kalamata, Greece.
EM k.liva@go.uop.gr; ath.panagiotopoulos@go.uop.gr;
   alexandra.foscolou@go.uop.gr; camer@hua.gr; kargyri@uop.gr;
   gpanouts@uop.gr; akaliora@hua.gr; a.gioxari@go.uop.gr
RI Panagiotopoulos, Athanasios/JBJ-6143-2023; Amerikanou,
   Charalampia/ABE-1634-2022; Kaliora, Andriana/AAM-2912-2021; Gioxari,
   Aristea/AAA-1163-2021
OI Panagiotopoulos, Athanasios A./0000-0002-8015-0484
CR Alvarez-Amor L, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-87761-3
   Amerikanou C, 2022, NUTRIENTS, V14, DOI 10.3390/nu14235064
   Rincón-Cervera MA, 2016, NUTRITION, V32, P1254, DOI 10.1016/j.nut.2016.04.006
   Bigagli E, 2018, LIFESTYLE GENOM, V11, P99, DOI 10.1159/000495516
   Chew NWS, 2023, CELL METAB, V35, P414, DOI 10.1016/j.cmet.2023.02.003
   Coppens P., 2012, Eur. Food Feed Law Rev
   Dayi Taygun, 2022, J Prev Med Hyg, V63, pE56, DOI 10.15167/2421-4248/jpmh2022.63.2S3.2747
   Rodriguez-Pérez MD, 2023, NUTRIENTS, V15, DOI 10.3390/nu15020377
   Dominguez LJ, 2023, EXP GERONTOL, V174, DOI 10.1016/j.exger.2023.112121
   Estruch R, 2018, NEW ENGL J MED, V378, DOI [10.1056/NEJMoa1800389, 10.1056/NEJMoa1200303, 10.1056/nejmoa1800389]
   europa.eu, 2024, Overweight and Obesity-BMI Statistics
   Farràs M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030601
   Farràs M, 2015, MOL NUTR FOOD RES, V59, P1758, DOI 10.1002/mnfr.201500030
   Finicelli M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13113831
   Foscolou A, 2018, MATURITAS, V118, P60, DOI 10.1016/j.maturitas.2018.10.013
   Francisco V, 2019, J AGR FOOD CHEM, V67, P3845, DOI 10.1021/acs.jafc.8b06723
   Gioxari A, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph192215347
   Halder S., 2023, Eur. J. Med. Health Sci, V5, P101, DOI [10.34104/ejmhs.023.01010107, DOI 10.34104/EJMHS.023.01010107]
   Higgins JPT, 2024, Cochrane Handbook for Systematic Reviews of Interventions version 6.5
   Hildebrandt X, 2023, CELL DEATH DIFFER, V30, P279, DOI 10.1038/s41418-022-01062-4
   Jurado-Ruiz E, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-47904-z
   Jurado-Ruiz E, 2017, MOL NUTR FOOD RES, V61, DOI [10.1002/mnfr.201770034, 10.1002/mnfr.201600549]
   Kaliora AC, 2019, J MED FOOD, V22, P729, DOI 10.1089/jmf.2018.0020
   Kany S, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20236008
   Katsa ME, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25020908
   Katsarou AI, 2016, EUR J NUTR, V55, P1283, DOI 10.1007/s00394-015-0947-5
   Katsarou AI, 2015, INT J FOOD SCI NUTR, V66, P766, DOI 10.3109/09637486.2015.1088936
   Khandouzi N, 2021, INT J FOOD SCI NUTR, V72, P548, DOI 10.1080/09637486.2020.1841123
   Lafraxo H, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/9949056
   Lama A, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600418
   Liberale L, 2024, INT J CARDIOL, V400, DOI 10.1016/j.ijcard.2024.131791
   Lu Y, 2024, FOOD SCI HUM WELL, V13, P529, DOI 10.26599/FSHW.2022.9250047
   Luque-Sierra A, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201800295
   Martín-Peláez S, 2017, EUR J NUTR, V56, P663, DOI 10.1007/s00394-015-1110-z
   Martín-Peláez S, 2016, NUTRIENTS, V8, DOI 10.3390/nu8040213
   Mehmood A, 2020, FOOD SCI NUTR, V8, P4639, DOI 10.1002/fsn3.1668
   Milhem F, 2023, METABOLITES, V13, DOI 10.3390/metabo13091016
   Murray CJL, 2020, LANCET, V396, P1223, DOI [10.1016/S0140-6736(20)30752-2, 10.1016/S0140-6736(20)30925-9]
   Neeland IJ, 2024, NAT REV DIS PRIMERS, V10, DOI 10.1038/s41572-024-00563-5
   Okunogbe A, 2021, BMJ GLOB HEALTH, V6, DOI 10.1136/bmjgh-2021-006351
   Papadaki A, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113342
   Pastor R, 2021, FREE RADICAL BIO MED, V172, P372, DOI 10.1016/j.freeradbiomed.2021.06.017
   Patti AM, 2020, METABOLITES, V10, DOI 10.3390/metabo10100392
   Pedret A, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201800456
   Piccolella S, 2019, J PHARMACEUT BIOMED, V175, DOI 10.1016/j.jpba.2019.07.022
   Pojero F, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24010380
   Quetglas-Llabrés MM, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12040833
   Rizzo M, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25158311
   Romani A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081776
   Roth GA, 2020, J AM COLL CARDIOL, V76, P2982, DOI 10.1016/j.jacc.2020.11.010
   Ruiz-García I, 2023, CLIN NUTR, V42, P1389, DOI 10.1016/j.clnu.2023.06.027
   Ruocco C, 2022, NUTR METAB CARDIOVAS, V32, P1571, DOI 10.1016/j.numecd.2022.03.020
   Sanchez-Rodriguez E, 2018, NUTRIENTS, V10, DOI 10.3390/nu10050626
   Santangelo C, 2016, J ENDOCRINOL INVEST, V39, P1295, DOI 10.1007/s40618-016-0506-9
   Sarapis K, 2020, NUTRIENTS, V12, DOI 10.3390/nu12082272
   Seidita A, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.980429
   Serreli G, 2024, CELLS-BASEL, V13, DOI 10.3390/cells13181555
   Swarup S., 2024, STATPEARLS
   World Health Organization, 2024, Obesity and Overweight. WHO Fact Sheets
NR 59
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 2039-7275
EI 2039-7283
J9 CLINICS PRACT
JI Clin. Pract.
PD MAR 7
PY 2025
VL 15
IS 3
AR 54
DI 10.3390/clinpract15030054
PG 19
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA 0OE5T
UT WOS:001452037800001
PM 40136590
OA gold
DA 2025-06-11
ER

PT J
AU Ittichaicharoen, J
   Phrommintikul, A
   Chattipakorn, N
   Chattipakorn, S
AF Ittichaicharoen, Jitjiroj
   Phrommintikul, Arintaya
   Chattipakorn, Nipon
   Chattipakorn, Siriporn
TI Reduced salivary amylase activity in metabolic syndrome patients with
   obesity could be improved by treatment with a dipeptidyl peptidase IV
   inhibitor
SO CLINICAL ORAL INVESTIGATIONS
LA English
DT Article
DE Obesity; Metabolic syndrome; Salivary gland function; Amylase activity;
   Vildagliptin
ID DIABETES-MELLITUS; ALPHA-AMYLASE; MITOCHONDRIAL-FUNCTION; SYSTEMIC
   INFLAMMATION; OXIDATIVE STRESS; GLYCEMIC CONTROL; GLUCOSE;
   HYPERGLYCEMIA; GLYCATION; GLANDS
AB ObjectivesThe present study is to investigate the salivary gland function of metabolic syndrome (MetS) patients, as indicated by salivary flow rate, amylase activity, and salivary oxidative stress, by measuring MDA level.Materials and methodsOne hundred and eighty-one MetS patients from Maharaj Nakorn Chiang Mai Hospital were enrolled onto this study. The metabolic parameters of each patient were collected and evaluated. Unstimulated saliva was also collected for 5min. Salivary gland functions, including salivary flow rate, amylase activity, and salivary MDA levels, were investigated.ResultsHigh levels of triglycerides, high-density lipoprotein, blood pressure, and waist circumference in MetS patients did not show a correlation with altered salivary gland function. However, a decrease in salivary flow rate was observed in MetS patients with hyperglycemia. In addition, decreased amylase activity was found in MetS patients with obesity (BMI23kg/m(2)). Salivary amylase activity of MetS patients treated with dipeptidyl peptidase IV (DPP-IV) inhibitor was significantly greater than that observed in MetS patients without a DPP-IV inhibitor. Moreover, the salivary amylase activity in MetS patients was found to be independently positively correlated with DPP-IV inhibitor therapy (r=0.708, p<0.01).ConclusionThese findings suggest that obesity and hyperglycemia in MetS patients were associated with the impairment of salivary glands. Treatment with a DPP-IV inhibitor was found to exert beneficial effects on the salivary gland.Clinical relevanceThis study demonstrated the impairment of salivary glands of MetS patients and the beneficial effect of DPP-IV inhibitor treatment in the salivary glands.
C1 [Ittichaicharoen, Jitjiroj; Chattipakorn, Siriporn] Chiang Mai Univ, Fac Dent, Dept Oral Biol & Diagnost Sci, Chiang Mai 50200, Thailand.
   [Ittichaicharoen, Jitjiroj; Chattipakorn, Nipon; Chattipakorn, Siriporn] Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Neurophysiol Unit, Chiang Mai 50200, Thailand.
   [Ittichaicharoen, Jitjiroj; Phrommintikul, Arintaya; Chattipakorn, Nipon; Chattipakorn, Siriporn] Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai 50200, Thailand.
   [Phrommintikul, Arintaya] Chiang Mai Univ, Fac Med, Dept Internal Med, Cardiol Unit, Chiang Mai 50200, Thailand.
   [Chattipakorn, Nipon] Chiang Mai Univ, Fac Med, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai 50200, Thailand.
C3 Chiang Mai University; Chiang Mai University; Chiang Mai University;
   Chiang Mai University; Chiang Mai University
RP Chattipakorn, S (corresponding author), Chiang Mai Univ, Fac Dent, Dept Oral Biol & Diagnost Sci, Chiang Mai 50200, Thailand.; Chattipakorn, S (corresponding author), Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Neurophysiol Unit, Chiang Mai 50200, Thailand.; Chattipakorn, S (corresponding author), Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai 50200, Thailand.
EM scchattipakorn@gmail.com
RI Phrommintikul, Arintaya/X-1881-2019; Chattipakorn, Nipon/AAJ-4049-2021
OI Chattipakorn, Siriporn/0000-0003-1677-7052; Phrommintikul,
   Arintaya/0000-0003-3986-1951
FU TRF-Senior Research Scholar [RTA6080003, RSA5780040]; Chiang Mai
   University [PHD/021/2556]; NSTDA Research Chair Grant from the National
   Science and Technology Development Agency Thailand; Chiang Mai
   University Center of Excellence Award; National Research Council of
   Thailand
FX TRF-Senior Research Scholar RTA6080003 (SC) and RSA5780040 (AP); the
   National Research Council of Thailand (SC); a CMU50th Anniversary grant
   by Chiang Mai University (PHD/021/2556 JI & a NSTDA Research Chair Grant
   from the National Science and Technology Development Agency Thailand
   (NC) and a Chiang Mai University Center of Excellence Award (NC).
CR Al-Rawi NH, 2011, DIABETES VASC DIS RE, V8, P22, DOI 10.1177/1479164110390243
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Amerongen AVN, 2002, ORAL DIS, V8, P12, DOI 10.1034/j.1601-0825.2002.1o816.x
   Andersson AB, 1998, EUR J ORAL SCI, V106, P931, DOI 10.1046/j.0909-8836.1998.eos106505.x
   [Anonymous], 2006, The IDF consensus worldwide definition of the metabolic syndrome
   Apaijai N, 2014, CARDIOVASC DRUG THER, V28, P549, DOI 10.1007/s10557-014-6553-6
   Apaijai N, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0102374
   ASKING B, 1985, ACTA PHYSIOL SCAND, V124, P535, DOI 10.1111/j.1748-1716.1985.tb00045.x
   Aydin S, 2007, J BIOCHEM MOL BIOL, V40, P29
   Barba C, 2004, LANCET, V363, P157, DOI 10.1016/s0140-6736(03)15268-3
   Bernardi Maria Jose, 2007, Oral Health Prev Dent, V5, P73
   Bonnefond A, 2017, BMC MED, V15, DOI 10.1186/s12916-017-0784-x
   Canale MP, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/865965
   Chavez EM, 2000, ORAL SURG ORAL MED O, V89, P305, DOI 10.1016/S1079-2104(00)70093-X
   Dey A, 2010, LIFE SCI, V87, P197, DOI 10.1016/j.lfs.2010.06.007
   Dodds MWJ, 1997, ORAL SURG ORAL MED O, V83, P465, DOI 10.1016/S1079-2104(97)90147-5
   Dodds MWJ, 2000, COMMUNITY DENT ORAL, V28, P373, DOI 10.1034/j.1600-0528.2000.028005373.x
   Falchi M, 2014, NAT GENET, V46, P492, DOI 10.1038/ng.2939
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Hayward Michele C, 2009, Semin Oncol Nurs, V25, P203, DOI 10.1016/j.soncn.2009.05.003
   Holst JJ, 2007, PHYSIOL REV, V87, P1409, DOI 10.1152/physrev.00034.2006
   Huang H, 2004, FRONT BIOSCI-LANDMRK, V9, P1100, DOI 10.2741/1298
   HUNT JV, 1988, BIOCHEM J, V256, P205, DOI 10.1042/bj2560205
   Ittichaicharoen J, 2017, APPL PHYSIOL NUTR ME, V42, P420, DOI 10.1139/apnm-2016-0545
   Kogawa EM, 2016, CLIN ORAL INVEST, V20, P2083, DOI 10.1007/s00784-015-1705-z
   Malicka B, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000005211
   Malicka B, 2014, ADV CLIN EXP MED, V23, P225, DOI 10.17219/acem/37067
   Mandel AL, 2012, J NUTR, V142, P853, DOI 10.3945/jn.111.156984
   Motamedi S, 2017, METAB BRAIN DIS, V32, P651, DOI 10.1007/s11011-017-9997-0
   Nakajima K, 2016, WORLD J DIABETES, V7, P112, DOI 10.4239/wjd.v7.i6.112
   Nakajima K, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-34
   Nater UM, 2009, PSYCHONEUROENDOCRINO, V34, P486, DOI 10.1016/j.psyneuen.2009.01.014
   Noble R E, 2000, J Oral Sci, V42, P83
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Ono R, 2015, J ORAL BIOSCI, V57, P200, DOI 10.1016/j.job.2015.06.002
   Palmeira CM, 2007, TOXICOL APPL PHARM, V225, P214, DOI 10.1016/j.taap.2007.07.015
   Proctor GB, 2007, AUTON NEUROSCI-BASIC, V133, P3, DOI 10.1016/j.autneu.2006.10.006
   Puttaswamy KA, 2017, J INT SOC PREV COMMU, V7, P28, DOI 10.4103/2231-0762.200703
   Radhika T, 2014, ORAL MAXILLOFAC PATH, V5, P413, DOI 10.5005/jp-journals-10037-1001
   Rodrigues L, 2015, ARCH ORAL BIOL, V60, P854, DOI 10.1016/j.archoralbio.2015.02.015
   Rolo AP, 2006, TOXICOL APPL PHARM, V212, P167, DOI 10.1016/j.taap.2006.01.003
   Saleh J, 2015, ARCH ORAL BIOL, V60, P242, DOI 10.1016/j.archoralbio.2014.10.004
   Samaranayake L, 2007, INT DENT J, V57, P295, DOI 10.1111/j.1875-595X.2007.tb00135.x
   Sarnáglia GD, 2016, PARASITOLOGY, V143, P1647, DOI 10.1017/S003118201600127X
   Seals DR, 2004, DIABETES, V53, P276, DOI 10.2337/diabetes.53.2.276
   Segal AW, 2008, INT J BIOCHEM CELL B, V40, P604, DOI 10.1016/j.biocel.2007.10.003
   Sivasinprasasn S, 2015, AGE, V37, DOI 10.1007/s11357-015-9766-0
   Smriti Komal, 2016, J Oral Biol Craniofac Res, V6, P41, DOI 10.1016/j.jobcr.2015.12.004
   Thorp AA, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/341583
   Ueda H, 2013, OBES RES CLIN PRACT, V7, pE321, DOI 10.1016/j.orcp.2013.05.001
   Vaishnava P, 2011, AM J MED, V124, P997, DOI 10.1016/j.amjmed.2011.04.035
   Viljakainen H, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0131883
   Yim MB, 2001, ANN NY ACAD SCI, V928, P48, DOI 10.1111/j.1749-6632.2001.tb05634.x
NR 53
TC 2
Z9 2
U1 0
U2 24
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1432-6981
EI 1436-3771
J9 CLIN ORAL INVEST
JI Clin. Oral Investig.
PD DEC
PY 2018
VL 22
IS 9
BP 3113
EP 3120
DI 10.1007/s00784-018-2402-5
PG 8
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA GZ5VC
UT WOS:000449496900018
PM 29520469
DA 2025-06-11
ER

PT J
AU Andres, AM
   Kooren, JA
   Parker, SJ
   Tucker, KC
   Ravindran, N
   Ito, BR
   Huang, CQ
   Venkatraman, V
   Van Eyk, JE
   Gottlieb, RA
   Mentzer, RM
AF Andres, Allen M.
   Kooren, Joel A.
   Parker, Sarah J.
   Tucker, Kyle C.
   Ravindran, Nandini
   Ito, Bruce R.
   Huang, Chengqun
   Venkatraman, Vidya
   Van Eyk, Jennifer E.
   Gottlieb, Roberta A.
   Mentzer, Robert M., Jr.
TI Discordant signaling and autophagy response to fasting in hearts of
   obese mice: Implications for ischemia tolerance
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE metabolic syndrome; peroxisome proliferator-activated
   receptor-alpha/gamma; mammalian target of rapamycin; proteomics
ID METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; MYOCARDIAL PROTECTION;
   INFARCT SIZE; REPERFUSION; ACTIVATION; SKYLINE; GLUCOSE; MTORC1; MS/MS
AB Autophagy is regulated by nutrient and energy status and plays an adaptive role during nutrient deprivation and ischemic stress. Metabolic syndrome (MetS) is a hypernutritive state characterized by obesity, dyslipidemia, elevated fasting blood glucose levels, and insulin resistance. It has also been associated with impaired autophagic flux and larger-sized infarcts. We hypothesized that dietinduced obesity (DIO) affects nutrient sensing, explaining the observed cardiac impaired autophagy. We subjected male friend virus B NIH (FVBN) mice to a high-fat diet, which resulted in increased weight gain, fat deposition, hyperglycemia, insulin resistance, and larger infarcts after myocardial ischemia-reperfusion. Autophagic flux was impaired after 4 wk on a high-fat diet. To interrogate nutrientsensing pathways, DIO mice were subjected to overnight fasting, and hearts were processed for biochemical and proteomic analysis. Obese mice failed to upregulate LC3-II or to clear p62/SQSTM1 after fasting, although mRNA for LC3B and p62/SQSTM1 were appropriately upregulated in both groups, demonstrating an intact transcriptional response to fasting. Energy-and nutrient-sensing signal transduction pathways[AMPK and mammalian target of rapamycin (mTOR)] also responded appropriately to fasting, although mTOR was more profoundly suppressed in obese mice. Proteomic quantitative analysis of the hearts under fed and fasted conditions revealed broad changes in protein networks involved in oxidative phosphorylation, autophagy, oxidative stress, protein homeostasis, and contractile machinery. In many instances, the fasting response was quite discordant between lean and DIO mice. Network analysis implicated the peroxisome proliferator-activated receptor and mTOR regulatory nodes. Hearts of obese mice exhibited impaired autophagy, altered proteome, and discordant response to nutrient deprivation.
C1 [Andres, Allen M.; Kooren, Joel A.; Parker, Sarah J.; Tucker, Kyle C.; Huang, Chengqun; Venkatraman, Vidya; Van Eyk, Jennifer E.; Gottlieb, Roberta A.; Mentzer, Robert M., Jr.] Cedars Sinai Heart Inst, 8700 Beverly Blvd, Los Angeles, CA 90048 USA.
   [Andres, Allen M.; Kooren, Joel A.; Parker, Sarah J.; Tucker, Kyle C.; Huang, Chengqun; Venkatraman, Vidya; Van Eyk, Jennifer E.; Gottlieb, Roberta A.; Mentzer, Robert M., Jr.] Dept Med, Los Angeles, CA USA.
   [Andres, Allen M.; Kooren, Joel A.; Parker, Sarah J.; Tucker, Kyle C.; Huang, Chengqun; Venkatraman, Vidya; Van Eyk, Jennifer E.; Gottlieb, Roberta A.; Mentzer, Robert M., Jr.] Cedars Sinai Med Ctr, Barbra Streisand Womens Heart Ctr, Los Angeles, CA 90048 USA.
   [Ravindran, Nandini; Ito, Bruce R.] San Diego State Univ, Donald P Shiley BioSci Ctr, San Diego, CA 92182 USA.
C3 Cedars Sinai Medical Center; Cedars Sinai Medical Center; California
   State University System; San Diego State University
RP Andres, AM (corresponding author), Cedars Sinai Heart Inst, 8700 Beverly Blvd, Los Angeles, CA 90048 USA.
EM Allen.Andres@cshs.org
OI Van Eyk, Jennifer/0000-0001-9050-148X
FU National Heart, Lung, and Blood Institute [P01-HL-112730]; American
   Heart Association SDG Grant [15SDG23230013]; American Heart Association
   (AHA) [15SDG23230013] Funding Source: American Heart Association (AHA)
FX This work was supported by National Heart, Lung, and Blood Institute
   Grant P01-HL-112730 (to R. A. Gottlieb) and American Heart Association
   SDG Grant 15SDG23230013 (to A. M. Andres).
CR Andersen PS, 2012, BIOCHEM RES INT, V2012, DOI 10.1155/2012/685108
   Behl C, 2011, AUTOPHAGY, V7, P795, DOI 10.4161/auto.7.7.15844
   Bolli R, 2004, CIRC RES, V95, P125, DOI 10.1161/01.RES.0000137171.97172.d7
   Bouhidel O, 2008, AM J PHYSIOL-HEART C, V295, pH1580, DOI 10.1152/ajpheart.00379.2008
   Buettner R, 2007, OBESITY, V15, P798, DOI 10.1038/oby.2007.608
   Choi M, 2014, BIOINFORMATICS, V30, P2524, DOI 10.1093/bioinformatics/btu305
   Clavijo LC, 2006, CARDIOVASC REVASCULA, V7, P7, DOI 10.1016/j.carrev.2005.10.007
   Colasanti T, 2014, CELL DEATH DIS, V5, DOI 10.1038/cddis.2014.211
   Eng JK, 2013, PROTEOMICS, V13, P22, DOI 10.1002/pmic.201200439
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Giricz Z, 2012, J CARDIOVASC PHARM, V60, P125, DOI 10.1097/FJC.0b013e318256ce10
   Gottlieb RA, J MOL CELL IN PRESS
   Grundy SM, 2002, CIRCULATION, V105, P2696, DOI 10.1161/01.CIR.0000020650.86137.84
   Huang CQ, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020975
   Huang CQ, 2010, J CARDIOVASC TRANSL, V3, P365, DOI 10.1007/s12265-010-9189-3
   Jahania SM, 2013, J AM COLL SURGEONS, V216, P719, DOI 10.1016/j.jamcollsurg.2012.12.034
   Jaishy B, 2015, J LIPID RES, V56, P546, DOI 10.1194/jlr.M055152
   Kakhniashvili DG, 2004, MOL CELL PROTEOMICS, V3, P501, DOI 10.1074/mcp.M300132-MCP200
   Kane Lesley A, 2007, Methods Mol Biol, V357, P87
   Kaushik G, 2015, SCI TRANSL MED, V7, DOI 10.1126/scitranslmed.aaa5843
   Kazlauskiene L, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/s13098-015-0096-2
   Keller A, 2002, ANAL CHEM, V74, P5383, DOI 10.1021/ac025747h
   Kennedy AJ, 2010, DIS MODEL MECH, V3, P156, DOI 10.1242/dmm.003467
   Kim J, 2011, NAT CELL BIOL, V13, P132, DOI 10.1038/ncb2152
   Klionsky DJ, 2000, SCIENCE, V290, P1717, DOI 10.1126/science.290.5497.1717
   Lipinski MM, 2010, P NATL ACAD SCI USA, V107, P14164, DOI 10.1073/pnas.1009485107
   Ma XC, 2012, AUTOPHAGY, V8, P1394, DOI 10.4161/auto.21036
   Ma XC, 2012, CIRCULATION, V125, P3170, DOI 10.1161/CIRCULATIONAHA.111.041814
   MacLean B, 2010, BIOINFORMATICS, V26, P966, DOI 10.1093/bioinformatics/btq054
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Matsui Y, 2007, CIRC RES, V100, P914, DOI 10.1161/01.RES.0000261924.76669.36
   Miura T, 2008, BASIC RES CARDIOL, V103, P501, DOI 10.1007/s00395-008-0743-y
   Montgomery MK, 2013, DIABETOLOGIA, V56, P1129, DOI 10.1007/s00125-013-2846-8
   Nakadera E, 2016, BIOCHEM BIOPH RES CO, V469, P1104, DOI 10.1016/j.bbrc.2015.12.010
   Ni HM, 2011, AUTOPHAGY, V7, P188, DOI 10.4161/auto.7.2.14181
   Panchal SK, 2011, J BIOMED BIOTECHNOL, DOI 10.1155/2011/351982
   Perry CN, 2009, METHOD ENZYMOL, V453, P325, DOI 10.1016/S0076-6879(08)04016-0
   Pourpirali S, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0129750
   Reuter TY., 2007, Drug Discov. Today Dis. Models, V4, P3, DOI [DOI 10.1016/J.DDMOD.2007.09.004, 10.1016/J.DDMOD.2007.09.004, 10.1016/j.ddmod.2007.09.004]
   Sancak Y, 2010, CELL, V141, P290, DOI 10.1016/j.cell.2010.02.024
   Saric A, 2016, MOL BIOL CELL, V27, P321, DOI 10.1091/mbc.E15-05-0272
   Scherz-Shouval R, 2011, TRENDS BIOCHEM SCI, V36, P30, DOI 10.1016/j.tibs.2010.07.007
   Schilling B, 2012, MOL CELL PROTEOMICS, V11, P202, DOI 10.1074/mcp.M112.017707
   Schwartz Longacre L, 2011, CIRCULATION, V124, P1172, DOI 10.1161/CIRCULATIONAHA.111.032698
   Stransky LA, 2015, J BIOL CHEM, V290, P27360, DOI 10.1074/jbc.M115.659128
   Weikel KA, 2015, AM J PHYSIOL-CELL PH, V308, pC249, DOI 10.1152/ajpcell.00265.2014
   Yu L, 2010, NATURE, V465, P942, DOI 10.1038/nature09076
   Zoncu R, 2011, SCIENCE, V334, P678, DOI 10.1126/science.1207056
NR 48
TC 26
Z9 26
U1 0
U2 1
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD JUL
PY 2016
VL 311
IS 1
BP H219
EP H228
DI 10.1152/ajpheart.00041.2016
PG 10
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA DY3CZ
UT WOS:000384969700023
PM 27199111
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Cordero-Herrera, I
   Kozyra, M
   Zhuge, ZB
   Haworth, SM
   Moretti, C
   Peleli, M
   Caldeira-Dias, M
   Jahandideh, A
   Han, HR
   Cruz, JD
   Kleschyov, AL
   Montenegro, MF
   Ingelman-Sundberg, M
   Weitzberg, E
   Lundberg, JO
   Carlstrom, M
AF Cordero-Herrera, Isabel
   Kozyra, Mikael
   Zhuge, Zhengbing
   Haworth, Sarah McCann
   Moretti, Chiara
   Peleli, Maria
   Caldeira-Dias, Mayara
   Jahandideh, Arghavan
   Han Huirong
   Cruz, Josiane de Campos
   Kleschyov, Andrei L.
   Montenegro, Marcelo F.
   Ingelman-Sundberg, Magnus
   Weitzberg, Eddie
   Lundberg, Jon O.
   Carlstrom, Mattias
TI AMP-activated protein kinase activation and NADPH oxidase inhibition by
   inorganic nitrate and nitrite prevent liver steatosis
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE nitrate; nitrite; nitric oxide; steatosis; microbiota
ID METABOLIC SYNDROME; XANTHINE OXIDOREDUCTASE; INSULIN-RESISTANCE;
   ABDOMINAL OBESITY; REDUCTION; ASSOCIATION; MODULATION; GENERATION;
   PATHWAY; RISK
AB Advanced age and unhealthy dietary habits contribute to the increasing incidence of obesity and type 2 diabetes. These metabolic disorders, which are often accompanied by oxidative stress and compromised nitric oxide (NO) signaling, increase the risk of adverse cardiovascular complications and development of fatty liver disease. Here, we investigated the therapeutic effects of dietary nitrate, which is found in high levels in green leafy vegetables, on liver steatosis associated with metabolic syndrome. Dietary nitrate fuels a nitrate-nitrite-NO signaling pathway, which prevented many features of metabolic syndrome and liver steatosis that developed in mice fed a high-fat diet, with or without combination with an inhibitor of NOS (L-NAME). These favorable effects of nitrate were absent in germ-free mice, demonstrating the central importance of host microbiota in bioactivation of nitrate. In a human liver cell line (HepG2) and in a validated hepatic 3D model with primary human hepatocyte spheroids, nitrite treatment reduced the degree of metabolically induced steatosis (i.e., high glucose, insulin, and free fatty acids), as well as drug-induced steatosis (i.e., amiodarone). Mechanistically, the salutary metabolic effects of nitrate and nitrite can be ascribed to nitrite-derived formation of NO species and activation of soluble guanylyl cyclase, where xanthine oxidoreductase is proposed to mediate the reduction of nitrite. Boosting this nitrate-nitrite-NO pathway results in attenuation of NADPH oxidase-derived oxidative stress and stimulation of AMP-activated protein kinase and downstream signaling pathways regulating lipogenesis, fatty acid oxidation, and glucose homeostasis. These findings may have implications for novel nutrition-based preventive and therapeutic strategies against liver steatosis associated with metabolic dysfunction.
C1 [Cordero-Herrera, Isabel; Kozyra, Mikael; Zhuge, Zhengbing; Haworth, Sarah McCann; Moretti, Chiara; Peleli, Maria; Caldeira-Dias, Mayara; Jahandideh, Arghavan; Han Huirong; Cruz, Josiane de Campos; Kleschyov, Andrei L.; Montenegro, Marcelo F.; Ingelman-Sundberg, Magnus; Weitzberg, Eddie; Lundberg, Jon O.; Carlstrom, Mattias] Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden.
   [Kleschyov, Andrei L.] Freiberg Instruments Ltd, Lab Biophys, D-09599 Freiberg, Germany.
   [Weitzberg, Eddie] Karolinska Univ Hosp, Dept Perioperat Med & Intens Care, S-17176 Stockholm, Sweden.
C3 Karolinska Institutet; Karolinska Institutet; Karolinska University
   Hospital
RP Lundberg, JO; Carlstrom, M (corresponding author), Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden.
EM jon.lundberg@ki.se; mattias.carlstrom@ki.se
RI Kleschyov, Andrei/AAQ-7749-2021; Cruz, Josiane/L-9780-2017; Han,
   Huirong/JXM-0776-2024; Peleli, Maria/AAQ-2326-2021; Montenegro,
   Marcelo/AAX-7172-2020; Ingelman-Sundberg, Magnus/ABD-9302-2021;
   Carlstrom, Mattias/E-7350-2015; zhuge, zhengbing/E-8210-2017
OI Carlstrom, Mattias/0000-0001-9923-8729; Freitas Montenegro,
   Marcelo/0000-0001-9137-8145; McCann Haworth, Sarah/0000-0002-4299-5486;
   Moretti, Chiara/0000-0002-0434-0278; Ingelman-Sundberg,
   Magnus/0000-0002-7255-9079; Lundberg, Jon/0000-0002-0174-5210;
   Kleshchev, Andrey/0000-0003-2300-1236; zhuge,
   zhengbing/0000-0002-6002-6670
FU Novo Nordisk postdoctoral fellowship; Swedish Research Council
   [2015-02760, 2016-01381]; Swedish Heart and Lung Foundation [20140448,
   20170124]; Novo-Nordisk [2-4078/2014]; European Research Council
   Advanced Grant (ERC-AdG) Project HEPASPHER Grant [742020]; Karolinska
   Institutet [2-3707/2013, 2-1930/2016]; Knut and Alice Wallenberg
   Foundation [KAW2008.0149];  [2-560/2015]
FX We thank Freiberg Instruments Ltd for the use of their EPR equipment
   (Magnettech MiniScope MS5000). We thank Glucox Biotech AB Stockholm for
   the kind gift of their NADPH oxidase inhibitors (GLX481304 and
   GLX7013114). We thank Carina Nihlen, Annika Olsson, Margareta
   Stensdotter, and Inger Johansson (Karolinska Institutet) for technical
   assistance. I.C.-H. is supported by a Novo Nordisk postdoctoral
   fellowship run in partnership with the Karolinska Institutet. This work
   was supported by Swedish Research Council Grants 2015-02760 and
   2016-01381, by Swedish Heart and Lung Foundation Grants 20140448 and
   20170124, by Novo-Nordisk Grant 2-4078/2014, by European Research
   Council Advanced Grant (ERC-AdG) Project HEPASPHER Grant Agreement
   742020, and by research funds (2-560/2015) and internal Karolinska
   Institutet funding for doctoral education (KID) (2-3707/2013 and
   2-1930/2016). M.K. was funded by an MD PhD program [Clinical Scientist
   Training Programme (CSTP)] grant from the Karolinska Institutet. The
   confocal microscope used was obtained by funding from the Knut and Alice
   Wallenberg Foundation (Grant KAW2008.0149).
CR Ahluwalia A, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.116.003402
   Appel LJ, 1997, NEW ENGL J MED, V336, P1117, DOI 10.1056/NEJM199704173361601
   Bazzano LA, 2008, DIABETES CARE, V31, P1311, DOI 10.2337/dc08-0080
   BELL CC, 2016, SCI REP, V6
   Bondonno CP, 2017, STROKE, V48, P1724, DOI [10.1161/STROKEAHA.117.016844, 10.1161/strokeaha.117.016844]
   Bressler J, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0079466
   Cantu-Medellin N, 2013, NITRIC OXIDE-BIOL CH, V34, P19, DOI 10.1016/j.niox.2013.02.081
   Carlström M, 2010, P NATL ACAD SCI USA, V107, P17716, DOI 10.1073/pnas.1008872107
   CARTER P, 2010, BMJ BRIT MED J, V341
   Cook S, 2003, SWISS MED WKLY, V133, P360
   Deshmukh AS, 2010, DIABETOLOGIA, V53, P1142, DOI 10.1007/s00125-010-1716-x
   Després JP, 2008, ARTERIOSCL THROM VAS, V28, P1039, DOI 10.1161/ATVBAHA.107.159228
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Diehl AM, 2017, NEW ENGL J MED, V377, P2063, DOI 10.1056/NEJMra1503519
   Fernandez ML, 2004, THROMB HAEMOSTASIS, V92, P413, DOI 10.1160/TH04-02-0103
   Gao X, 2015, HYPERTENSION, V65, P161, DOI 10.1161/HYPERTENSIONAHA.114.04222
   Ghasemi A, 2017, NITRIC OXIDE-BIOL CH, V70, P9, DOI 10.1016/j.niox.2017.08.003
   Helms CC, 2017, BIOL CHEM, V398, P319, DOI 10.1515/hsz-2016-0263
   Hezel M, 2016, FREE RADICAL BIO MED, V99, P87, DOI 10.1016/j.freeradbiomed.2016.07.025
   Huang LY, 2010, NITRIC OXIDE-BIOL CH, V22, P191, DOI 10.1016/j.niox.2010.01.004
   Huang PL, 2009, TRENDS ENDOCRIN MET, V20, P295, DOI 10.1016/j.tem.2009.03.005
   Jansson EÅ, 2008, NAT CHEM BIOL, V4, P411, DOI 10.1038/nchembio.92
   Khambata RS, 2015, ANTIOXID REDOX SIGN, V23, P340, DOI 10.1089/ars.2015.6254
   Kleschyov AL, 2000, BIOCHEM BIOPH RES CO, V275, P672, DOI 10.1006/bbrc.2000.3361
   Kleschyov AL, 2017, FREE RADICAL BIO MED, V112, P544, DOI 10.1016/j.freeradbiomed.2017.08.025
   Kozyra M, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-32722-6
   Larsen FJ, 2011, CELL METAB, V13, P149, DOI 10.1016/j.cmet.2011.01.004
   Liese AD, 2009, DIABETES CARE, V32, P1434, DOI 10.2337/dc09-0228
   Litvinova L, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00020
   Lundberg JO, 2004, FREE RADICAL BIO MED, V37, P395, DOI 10.1016/j.freeradbiomed.2004.04.027
   Lundberg JO, 2008, NAT REV DRUG DISCOV, V7, DOI [10.1038/nrd2466-c2, 10.1038/nrd2466]
   Lundberg JO, 2015, NAT REV DRUG DISCOV, V14, P623, DOI 10.1038/nrd4623
   Lundberg JO, 2011, CARDIOVASC RES, V89, P525, DOI 10.1093/cvr/cvq325
   Lundberg JO, 2009, NAT CHEM BIOL, V5, P865, DOI 10.1038/nchembio.260
   Montenegro MF, 2011, FREE RADICAL BIO MED, V51, P144, DOI 10.1016/j.freeradbiomed.2011.04.005
   Monti LD, 2003, DIABETES, V52, P1270, DOI 10.2337/diabetes.52.5.1270
   Nyström T, 2012, FREE RADICAL BIO MED, V53, P1017, DOI 10.1016/j.freeradbiomed.2012.06.031
   Peleli M, 2016, FREE RADICAL BIO MED, V99, P472, DOI 10.1016/j.freeradbiomed.2016.09.004
   Peleli M, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00222
   Ruderman NB, 2013, J CLIN INVEST, V123, P2764, DOI 10.1172/JCI67227
   van Faassen EE, 2009, MED RES REV, V29, P683, DOI 10.1002/med.20151
   Vanin AF, 2016, NITRIC OXIDE-BIOL CH, V54, P15, DOI 10.1016/j.niox.2016.01.006
   Winerdal M, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0170545
   Yang T, 2017, REDOX BIOL, V13, P320, DOI 10.1016/j.redox.2017.06.002
   Yang T, 2015, FREE RADICAL BIO MED, V83, P159, DOI 10.1016/j.freeradbiomed.2015.02.016
NR 45
TC 74
Z9 80
U1 1
U2 31
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
EI 1091-6490
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD JAN 2
PY 2019
VL 116
IS 1
BP 217
EP 226
DI 10.1073/pnas.1809406115
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA HG1IT
UT WOS:000454707700036
PM 30559212
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Zaki, M
   Basha, W
   El-Bassyouni, HT
   El-Toukhy, S
   Hussein, T
AF Zaki, Moushira
   Basha, Walaa
   El-Bassyouni, Hala T.
   El-Toukhy, Safinaz
   Hussein, Tamer
TI Evaluation of DNA damage profile in obese women and its association to
   risk of metabolic syndrome, polycystic ovary syndrome and recurrent
   preeclampsia
SO GENES & DISEASES
LA English
DT Article
DE DNA damage; Metabolic components; Obesity; PCOS; Recurrent preeclampsia
ID OXIDATIVE STRESS; INFLAMMATION; ANTIOXIDANTS; LYMPHOCYTES; HEALTH; PCOS
AB Metabolic syndrome (MS) is a cluster of metabolic abnormalities. Obesity and MS are always accompanied by elevated oxidative stress which might affect cellular bio-molecules such as DNA. The aim of the present study is to investigate DNA damage profile in obese premenopausal women and its relation to the risk of MS, polycystic ovary syndrome (PCOS) and history of recurrent pre-eclampsia. The study included 90 obese women included cases with MS (n = 30), PCOS (n = 30) and previous history of recurrent preeclampsia (n = 30) and, age-matched healthy non-obese control women (n = 50). The assessment of leukocyte DNA damage was done by comet assay for all cases and controls. Anthropometry and biochemical parameters have been measured. Results showed that mean percent of DNA damage was significantly higher in MS, PCOS as well as in women with the recurrent preeclampsia as compared to healthy controls. The high level of mean DNA damage frequency in obese women was significantly associated with the increased number of metabolic syndrome components. Cases with 2, 3 and 3-5 components showed significantly higher levels of DNA damage than controls. Moreover, cases with 3-5 MS components showed significant higher DNA compared to those with the two components. Regarding PCOS, significant positive association between the mean frequency of DNA damage and waist circumference was observed. The study suggests that metabolic abnormalities, PCOS and recurrent pre-eclampsia might be contributed in development of DNA damage in obese women. DNA damage can serve as an early marker for obesity complications in premenopausal women. Copyright (C) 2018, Chongqing Medical University.
C1 [Zaki, Moushira; Basha, Walaa] Natl Res Ctr, Med Res Div, Biol Anthropol Dept, Cairo, Egypt.
   [El-Bassyouni, Hala T.] Natl Res Ctr, Clin Genet Dept, Cairo, Egypt.
   [El-Toukhy, Safinaz] Natl Res Ctr, Med Res Div, Med Biochem Dept, Cairo, Egypt.
   [Hussein, Tamer] Natl Res Ctr, Med Res Div, Reprod Hlth Res Dept, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); National Research Centre (NRC); Egyptian
   Knowledge Bank (EKB); National Research Centre (NRC); Egyptian Knowledge
   Bank (EKB); National Research Centre (NRC); Egyptian Knowledge Bank
   (EKB); National Research Centre (NRC)
RP Zaki, M (corresponding author), Natl Res Ctr, Med Res Div, Biol Anthropol Dept, Cairo, Egypt.
EM moushiraz@yahoo.com
RI eltoukhy, safinaz/M-1245-2019; El-Bassyouni, Hala/A-1955-2016; Basha,
   Walaa/B-4365-2016
OI El-Bassyouni, Hala/0000-0001-9825-1219; Basha,
   Walaa/0000-0002-4159-8139; Taha, Tamer/0000-0002-7091-3441
FU National Research Center, Egypt
FX Authors acknowledge the financial assistance provided by National
   Research Center, Egypt.
CR Alanbay I, 2012, ARCH GYNECOL OBSTET, V286, P1065, DOI 10.1007/s00404-012-2425-0
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Andreassi MG, 2008, J MOL MED, V86, P1033, DOI 10.1007/s00109-008-0358-7
   [Anonymous], WHO CHILD GROWTH STA
   Arroyo-Johnson C, 2016, GASTROENTEROL CLIN N, V45, P571, DOI 10.1016/j.gtc.2016.07.012
   Blaton VH, 2008, BIOCHEM MEDICA, V18, P14
   Bukhari SA, 2010, MOL BIOL REP, V37, P289, DOI 10.1007/s11033-009-9686-0
   Demirbag R, 2006, INT J CLIN PRACT, V60, P1187, DOI 10.1111/j.1742-1241.2006.01042.x
   Esteghamati A, 2013, AM J MED SCI, V346, P26, DOI 10.1097/MAJ.0b013e31826485de
   FERRANNINI E, 1991, DIABETOLOGIA, V34, P416, DOI 10.1007/BF00403180
   Fujimaki A, 2011, PLACENTA, V32, P367, DOI 10.1016/j.placenta.2011.02.004
   Furness DLF, 2010, MUTAGENESIS, V25, P489, DOI 10.1093/mutage/geq032
   Giovannelli L, 2002, CARCINOGENESIS, V23, P1483, DOI 10.1093/carcin/23.9.1483
   Goodarzi MT, 2010, J CLIN LAB ANAL, V24, P72, DOI 10.1002/jcla.20328
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Harma M, 2005, EUR J OBSTET GYN R B, V118, P47, DOI 10.1016/j.ejogrb.2004.04.012
   Hilali N, 2013, EUR J OBSTET GYN R B, V170, P377, DOI 10.1016/j.ejogrb.2013.07.031
   Hunt KJ, 2004, CIRCULATION, V110, P1251, DOI 10.1161/01.CIR.0000140762.04598.F9
   Jayawardena R, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-380
   Jonard S, 2005, HUM REPROD, V20, P2893, DOI 10.1093/humrep/dei159
   Kebapcilar AG, 2014, ARCH GYNECOL OBSTET, V290, P1255, DOI 10.1007/s00404-014-3353-y
   Mert I, 2012, J OBSTET GYNAECOL RE, V38, P658, DOI 10.1111/j.1447-0756.2011.01771.x
   Moran LJ, 2008, MUTAT RES-FUND MOL M, V639, P55, DOI 10.1016/j.mrfmmm.2007.11.007
   Ode KL, 2009, REV ENDOCR METAB DIS, V10, P167, DOI 10.1007/s11154-009-9115-7
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Qiao Q, 2010, EUR J CLIN NUTR, V64, P30, DOI 10.1038/ejcn.2009.93
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   Rytter E, 2009, BRIT J NUTR, V101, P1423, DOI 10.1017/S0007114508076204
   Scarpato R, 2011, FASEB J, V25, P685, DOI 10.1096/fj.10-168427
   SHIGENAGA MK, 1991, FREE RADICAL BIO MED, V10, P211, DOI 10.1016/0891-5849(91)90078-H
   SINGH NP, 1988, EXP CELL RES, V175, P184, DOI 10.1016/0014-4827(88)90265-0
   Siti HN, 2015, VASC PHARMACOL, V71, P40, DOI 10.1016/j.vph.2015.03.005
   Tanner JM., 1969, Human Biology. A Guide to Field Methods, P1
   Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
   Vassalle C, 2009, CLIN BIOCHEM, V42, P739, DOI 10.1016/j.clinbiochem.2008.11.017
   Violante FS, 2003, ENVIRON RES, V91, P135, DOI 10.1016/S0013-9351(02)00060-9
   Wiktor H, 2004, VIRCHOWS ARCH, V445, P74, DOI 10.1007/s00428-004-1024-2
   Yesilada E, 2006, EUR J ENDOCRINOL, V154, P563, DOI 10.1530/eje.1.02117
   Zaki M, 2018, GENE REP, V10, P42, DOI 10.1016/j.genrep.2017.10.012
NR 39
TC 23
Z9 26
U1 1
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2352-4820
EI 2352-3042
J9 GENES DIS
JI Genes Dis.
PD DEC
PY 2018
VL 5
IS 4
BP 367
EP 373
DI 10.1016/j.gendis.2018.03.001
PG 7
WC Biochemistry & Molecular Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA HE1SJ
UT WOS:000453053300011
PM 30591939
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Koziróg, M
   Poliwczak, AR
   Duchnowicz, P
   Koter-Michalak, M
   Sikora, J
   Broncel, M
AF Kozirog, Marzena
   Poliwczak, Adam Rafal
   Duchnowicz, Piotr
   Koter-Michalak, Maria
   Sikora, Joanna
   Broncel, Marlena
TI Melatonin treatment improves blood pressure, lipid profile, and
   parameters of oxidative stress in patients with metabolic syndrome
SO JOURNAL OF PINEAL RESEARCH
LA English
DT Article
DE blood pressure; melatonin; metabolic syndrome; oxidative stress
ID ESSENTIAL-HYPERTENSION; RATS; CHOLESTEROL; AUTOXIDATION; DAMAGE; WOMEN;
   DIET
AB Experimental studies have proven that melatonin has many beneficial pleiotropic actions. The aim of this study was to assess melatonin efficacy in patients with metabolic syndrome (MS). The study included 33 healthy volunteers (who were not treated with melatonin) and 30 patients with MS, who did not respond to 3-month lifestyle modification. Patients with MS were treated with melatonin (5 mg/day, 2 hr before bedtime) for 2 months. The following parameters were studied: systolic and diastolic blood pressure (SBP, DBP), levels of glucose, serum lipids, C-reactive protein, fibrinogen, activities of antioxidative enzymes: catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), thiobarbituric acid reactive substrates (TBARS). After 2-month therapy in comparison with baseline, the following significant changes were measured: systolic blood pressure (132.8 +/- 9.8 versus 120.5 +/- 11.0 mmHg, P < 0.001), DBP (81.7 +/- 8.8 versus 75 +/- 7.4 mmHg, P < 0.01), low-density lipoprotein cholesterol (LDL-C) (149.7 +/- 26.4 versus 139.9 +/- 30.2 mg/dL, P < 0.05), TBARS (0.5 +/- 0.2 versus 0.4 +/- 0.1 mu m/gHb, P < 0.01), and CAT (245.9 +/- 46.9 versus 276.8 +/- 39.4 U/gHb). Melatonin administered for 2 months significantly improved antioxidative defense (increase in CAT activity, decrease in TBARS level) and lipid profile (decrease in LDL-C), and lowered blood pressure. We conclude that melatonin therapy may be of benefit for patients with MS, particularly with arterial hypertension. Further studies with higher doses of melatonin or prolonged supplementation are awaited.
C1 [Kozirog, Marzena; Poliwczak, Adam Rafal; Broncel, Marlena] Med Univ Lodz, Dept Internal Dis & Clin Pharmacol, PL-91347 Lodz, Poland.
   [Duchnowicz, Piotr; Koter-Michalak, Maria] Univ Lodz, Dept Environm Pollut Biophys, PL-90131 Lodz, Poland.
   [Sikora, Joanna] Med Univ Lodz, Dept Pharmaceut Chem & Drug Anal, PL-91347 Lodz, Poland.
C3 Medical University Lodz; University of Lodz; Medical University Lodz
RP Broncel, M (corresponding author), Med Univ Lodz, Dept Internal Dis & Clin Pharmacol, Kniaziewicza St 1-5, PL-91347 Lodz, Poland.
EM marlena.broncel@umed.lodz.pl
RI Sikora, Joanna/J-5197-2012; Poliwczak, Adam/AAT-6218-2020; Duchnowicz,
   Piotr/F-2162-2018
OI Duchnowicz, Piotr/0000-0002-3514-9716; Sikora,
   Joanna/0000-0001-7044-9696; Broncel, Marlena/0000-0003-3659-8115;
   Poliwczak, Adam/0000-0002-5281-0318; Koter-Michalak,
   Maria/0000-0001-8660-4136
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Allegra M, 2003, J PINEAL RES, V34, P1, DOI 10.1034/j.1600-079X.2003.02112.x
   BEERS RF, 1952, J BIOL CHEM, V195, P133
   Cagnacci A, 2005, AM J HYPERTENS, V18, P1614, DOI 10.1016/j.amjhyper.2005.05.008
   Carampin P, 2003, J PINEAL RES, V34, P134, DOI 10.1034/j.1600-079X.2003.00020.x
   Cavallo A, 2004, PEDIATR DIABETES, V5, P26, DOI 10.1111/j.1399-543X.2004.00031.x
   Cavallo A, 2004, J PINEAL RES, V36, P262, DOI 10.1111/j.1600-079X.2004.00126.x
   CHAN TY, 1995, ENDOCR RES, V21, P681, DOI 10.1080/07435809509030483
   Dauchy RT, 2003, COMPARATIVE MED, V53, P186
   De Filippis D, 2008, J PINEAL RES, V44, P45, DOI 10.1111/j.1600-079X.2007.00526.x
   Ding CN, 2001, ACTA PHARMACOL SIN, V22, P997
   DRABKIN DL, 1946, J BIOL CHEM, V164, P703
   Gitto E, 2009, J PINEAL RES, V46, P128, DOI 10.1111/j.1600-079X.2008.00649.x
   Grossman E, 2006, AM J MED, V119, P898, DOI 10.1016/j.amjmed.2006.02.002
   Hardeland R, 2009, J PINEAL RES, V47, P109, DOI 10.1111/j.1600-079X.2009.00701.x
   Hoyos M, 2000, J PINEAL RES, V28, P150
   Hussain SAR, 2007, J PINEAL RES, V42, P267, DOI 10.1111/j.1600-079X.2006.00415.x
   Jonas M, 2003, BLOOD PRESSURE, V12, P19, DOI 10.1080/08037050310000418
   Jung KH, 2010, J PINEAL RES, V48, P239, DOI 10.1111/j.1600-079X.2010.00748.x
   Kedziora-Kornatowska K, 2008, J PINEAL RES, V45, P312, DOI 10.1111/j.1600-079X.2008.00592.x
   Kedziora-Kornatowska K, 2009, J PINEAL RES, V46, P333, DOI 10.1111/j.1600-079X.2009.00666.x
   Lee YD, 2009, J PINEAL RES, V46, P53, DOI 10.1111/j.1600-079X.2008.00621.x
   MISRA HP, 1972, J BIOL CHEM, V247, P3170
   MULLERWIELAND D, 1994, BIOCHEM BIOPH RES CO, V203, P416, DOI 10.1006/bbrc.1994.2198
   Okatani Y, 2001, EUR J PHARMACOL, V417, P125, DOI 10.1016/S0014-2999(01)00802-0
   Pan M, 2006, J PINEAL RES, V41, P79, DOI 10.1111/j.1600-079X.2006.00346.x
   Pechánová O, 2007, EUR J PHARMACOL, V561, P129, DOI 10.1016/j.ejphar.2007.01.035
   Reiter RJ, 2002, J PHARM PHARMACOL, V54, P1299, DOI 10.1211/002235702760345374
   Reiter RJ, 2009, CRIT REV BIOCHEM MOL, V44, P175, DOI 10.1080/10409230903044914
   RICEEVANS CA, 1991, FREE RADICAL RES, P194
   Robeva R, 2008, J PINEAL RES, V44, P52, DOI 10.1111/j.1600-079X.2007.00527.x
   Rodriguez C, 2004, J PINEAL RES, V36, P1, DOI 10.1046/j.1600-079X.2003.00092.x
   Samantaray S, 2008, J PINEAL RES, V44, P348, DOI 10.1111/j.1600-079X.2007.00534.x
   Sanchez-Mateos S, 2007, MATURITAS, V58, P91, DOI 10.1016/j.maturitas.2007.06.006
   Scheer FAJL, 2004, HYPERTENSION, V43, P192, DOI 10.1161/01.HYP.0000113293.15186.3b
   Simko F, 2009, J PINEAL RES, V47, P127, DOI 10.1111/j.1600-079X.2009.00697.x
   Stergiou GS, 2002, STROKE, V33, P1480, DOI 10.1161/01.STR.0000016971.48972.14
   Stern MP, 2004, DIABETES CARE, V27, P2676, DOI 10.2337/diacare.27.11.2676
   STOCKS J, 1971, BRIT J HAEMATOL, V20, P95, DOI 10.1111/j.1365-2141.1971.tb00790.x
   Tamura H, 2008, J PINEAL RES, V45, P101, DOI 10.1111/j.1600-079X.2008.00561.x
   Tamura H, 2008, J PINEAL RES, V44, P280, DOI 10.1111/j.1600-079X.2007.00524.X
   Tan DX, 2007, J PINEAL RES, V42, P28, DOI 10.1111/j.1600-079X.2006.00407.x
   Tengattini S, 2008, J PINEAL RES, V44, P16, DOI 10.1111/j.1600-079X.2007.00518.x
   Zeman M, 2005, LIFE SCI, V76, P1795, DOI 10.1016/j.lfs.2004.08.034
NR 44
TC 223
Z9 229
U1 2
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3098
EI 1600-079X
J9 J PINEAL RES
JI J. Pineal Res.
PD APR
PY 2011
VL 50
IS 3
BP 261
EP 266
DI 10.1111/j.1600-079X.2010.00835.x
PG 6
WC Endocrinology & Metabolism; Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Physiology
GA 733KW
UT WOS:000288262600004
PM 21138476
DA 2025-06-11
ER

PT J
AU Leber, B
   Tripolt, NJ
   Blattl, D
   Eder, M
   Wascher, TC
   Pieber, TR
   Stauber, R
   Sourij, H
   Oettl, K
   Stadlbauer, V
AF Leber, B.
   Tripolt, N. J.
   Blattl, D.
   Eder, M.
   Wascher, T. C.
   Pieber, T. R.
   Stauber, R.
   Sourij, H.
   Oettl, K.
   Stadlbauer, V.
TI The influence of probiotic supplementation on gut permeability in
   patients with metabolic syndrome: an open label, randomized pilot study
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE endotoxin; gut permeability; metabolic syndrome; Lactobacillus casei
   Shirota
ID DIET-INDUCED OBESITY; POLYMORPHONUCLEAR LEUKOCYTES CONSTITUTE; OXIDATIVE
   STRESS; INTESTINAL PERMEABILITY; INSULIN-RESISTANCE; POSSIBLE LINK;
   HUMAN SERUM; INFLAMMATION; ENDOTOXEMIA; MICROBIOTA
AB BACKGROUND/OBJECTIVES: Obesity and metabolic disorders are linked to inflammation via gut microbiota and/or gut permeability. Gut-derived endotoxin triggers inflammation leading to metabolic syndrome (MetS) and contributing to oxidative stress. We intended to investigate the effect of Lactobacillus casei Shirota on gut permeability, presence of endotoxin and neutrophil function in MetS.
   SUBJECTS/METHODS: Patients with MetS were randomized to receive 3 x 6.5 x 10(9) CFU L. casei Shirota (probiotic group) or not for 3 months. Gut permeability was assessed by a differential sugar absorption method and by determination of diaminooxidase serum levels, endotoxin by an adapted limulus amoebocyte lysate assay, neutrophil function and toll-like receptor (TLR) expression by flow cytometry and ELISA was used to detect lipopolysaccharide-binding protein (LBP) and soluble CD14 (sCD14) levels.
   RESULTS: Twenty-eight patients and 10 healthy controls were included. Gut permeability was significantly increased in MetS compared with controls but did not differ between patient groups. None of the patients were positive for endotoxin. LBP and sCD14 levels were not significantly different from healthy controls. High-sensitive C-reactive protein and LBP levels slightly but significantly increased after 3 months within the probiotics group. Neutrophil function and TLR expression did not differ from healthy controls or within the patient groups.
   CONCLUSIONS: Gut permeability of MetS patients was increased significantly compared with healthy controls. L. casei Shirota administration in the MetS patients did not have any influence on any parameter tested possibly due to too-short study duration or underdosing of L. casei Shirota.
C1 [Tripolt, N. J.; Eder, M.; Sourij, H.] Med Univ Graz, Cardiovasc Diabetol Res Grp, Div Endocrinol & Metab, Dept Internal Med, A-8010 Graz, Austria.
   [Leber, B.; Blattl, D.] Med Univ Graz, Dept Surg, Div Transplantat Surg, A-8010 Graz, Austria.
   [Wascher, T. C.] Hanusch Hosp, Dept Med 1, Vienna, Austria.
   [Stauber, R.; Stadlbauer, V.] Med Univ Graz, Div Gastroenterol & Hepatol, Dept Internal Med, A-8010 Graz, Austria.
   [Oettl, K.] Med Univ Graz, Inst Physiol Chem, A-8010 Graz, Austria.
C3 Medical University of Graz; Medical University of Graz; WGKK - Hanusch
   Hospital; Medical University of Graz; Medical University of Graz
RP Sourij, H (corresponding author), Med Univ Graz, Cardiovasc Diabetol Res Grp, Div Endocrinol & Metab, Dept Internal Med, Auenbruggerpl 15, A-8010 Graz, Austria.
EM ha.sourij@medunigraz.at
RI Tripolt, Norbert/AFP-4429-2022; Sourij, Harald/V-3370-2019
OI Tripolt, Norbert/0000-0002-7566-2047; Stadlbauer,
   Vanessa/0000-0001-5508-8271; Oettl, Karl/0000-0001-9792-5760; Sourij,
   Harald/0000-0003-3510-9594; Pieber, Thomas/0000-0003-3554-0405
FU Yakult Europe; Oesterreichische Nationalbank [12930, 13699]; Austrian
   Science Fund [P24362]; Styrian Government [A3-16.M-1/2011-25]
FX This work was supported in part by Yakult Europe. BL, ME and NJT are
   supported by funds of the Oesterreichische Nationalbank (Anniversary
   Fund, project numbers: 12930 to VS and 13699 to HS), the Austrian
   Science Fund (project P24362 to VS) and the Styrian Government (project
   A3-16.M-1/2011-25 to HS). We thank the team of the 'Centre for medical
   Research' (ZMF) of the Medical University of Graz for technical support.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Bäckhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Creely SJ, 2007, AM J PHYSIOL-ENDOC M, V292, pE740, DOI 10.1152/ajpendo.00302.2006
   Farah R, 2010, MINERVA CARDIOANGIOL, V58, P175
   Farhadi A, 2008, LIVER INT, V28, P1026, DOI 10.1111/j.1478-3231.2008.01723.x
   ISOLAURI E, 1993, GASTROENTEROLOGY, V105, P1643, DOI 10.1016/0016-5085(93)91059-Q
   Lassenius MI, 2011, DIABETES CARE, V34, P1809, DOI 10.2337/dc10-2197
   Leber B, 2012, TRANSL RES, V159, P487, DOI 10.1016/j.trsl.2011.12.005
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Ley RE, 2010, CURR OPIN GASTROEN, V26, P5, DOI 10.1097/MOG.0b013e328333d751
   Li ZP, 2003, HEPATOLOGY, V37, P343, DOI 10.1053/jhep.2003.50048
   Manco M, 2010, ENDOCR REV, V31, P817, DOI 10.1210/er.2009-0030
   Mazor R, 2008, ATHEROSCLEROSIS, V197, P937, DOI 10.1016/j.atherosclerosis.2007.08.014
   Membrez M, 2008, FASEB J, V22, P2416, DOI 10.1096/fj.07-102723
   Naito E, 2011, J APPL MICROBIOL, V110, P650, DOI 10.1111/j.1365-2672.2010.04922.x
   Pascual S, 2003, HEPATO-GASTROENTEROL, V50, P1482
   Sandek A, 2007, J AM COLL CARDIOL, V50, P1561, DOI 10.1016/j.jacc.2007.07.016
   Sheu WHH, 2008, OBESITY, V16, P1033, DOI 10.1038/oby.2008.37
   Solá E, 2009, OBES SURG, V19, P571, DOI 10.1007/s11695-008-9772-8
   Song WB, 2009, WORLD J GASTROENTERO, V15, P3916, DOI 10.3748/wjg.15.3916
   Stadlbauer V, 2008, J HEPATOL, V48, P945, DOI 10.1016/j.jhep.2008.02.015
   Stadlbauer V, 2007, J HEPATOL, V47, P726, DOI 10.1016/j.jhep.2007.08.001
   SUTHERLAND LR, 1994, LANCET, V343, P998, DOI 10.1016/S0140-6736(94)90125-2
   Tilg H, 2011, J CLIN INVEST, V121, P2126, DOI 10.1172/JCI58109
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Wolowczuk I, 2008, CLIN DEV IMMUNOL, P1, DOI 10.1155/2008/639803
   Zakostelska Z, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027961
NR 30
TC 88
Z9 104
U1 0
U2 33
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0954-3007
EI 1476-5640
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD OCT
PY 2012
VL 66
IS 10
BP 1110
EP 1115
DI 10.1038/ejcn.2012.103
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 018FS
UT WOS:000309646100007
PM 22872030
OA Bronze
DA 2025-06-11
ER

PT J
AU López-Uriarte, P
   Nogués, R
   Saez, G
   Bulló, M
   Romeu, M
   Masana, L
   Tormos, C
   Casas-Agustench, P
   Salas-Salvadó, J
AF Lopez-Uriarte, Patricia
   Nogues, Rosa
   Saez, Guillermo
   Bullo, Monica
   Romeu, Marta
   Masana, Lluis
   Tormos, Carmen
   Casas-Agustench, Patricia
   Salas-Salvado, Jordi
TI Effect of nut consumption on oxidative stress and the endothelial
   function in metabolic syndrome
SO CLINICAL NUTRITION
LA English
DT Article
DE Nuts; Antioxidant capacity; Lipid oxidation; DNA damage; Endothelial
   function; Metabolic syndrome
ID LOW-DENSITY-LIPOPROTEIN; RANDOMIZED CROSSOVER TRIAL; ABSORBENCY CAPACITY
   ASSAY; ENRICHED DIET INCREASES; CORONARY-HEART-DISEASE; DNA-DAMAGE;
   IN-VITRO; HYPERCHOLESTEROLEMIC SUBJECTS; CARDIOVASCULAR-DISEASE; ALMOND
   CONSUMPTION
AB Background & aims: Oxidative stress has a key role in atherosclerosis, cancer and other chronic diseases. Some bioactive compounds in nuts have been implicated in antioxidant activities. Objective: We assessed how nut consumption affected several markers of oxidation and endothelial function (EF) in metabolic syndrome (MetS) patients.
   Patients and methods: A randomized, controlled, parallel feeding trial was conducted on 50 MetS adults who were recommended a healthy diet supplemented or not with 30 g of mixed nuts (Nut and Control groups, respectively) every day for 12 weeks. The plasma antioxidant capacity (AC), oxidized LDL (oxLDL), conjugated diene (CD) formation, urine 8-isoprostanes, DNA damage assessed by yield of urine 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG), and EF assessed by peripheral artery tonometry (PAT) and biochemical markers, were measured at baseline and the end of the intervention.
   Results: No significant differences in changes between groups were observed in AC, oxLM, CD, 8-isoprostanes or EF during the intervention, whereas the reduction in DNA damage was significant in the Nut group compared to Control group (P < 0.001).
   Conclusion: Nut consumption has no deleterious effect on lipid oxidation. The decrease in DNA damage observed in this study could contribute to explain the beneficial effects of regular nut consumption on some MetS features and several chronic diseases. (c) 2009 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Lopez-Uriarte, Patricia; Bullo, Monica; Casas-Agustench, Patricia; Salas-Salvado, Jordi] Univ Rovira & Virgili, Hosp Univ St Joan de Reus, Fac Med & Hlth Sci, Human Nutr Unit,IISPV, Tarragona 43201, Spain.
   [Nogues, Rosa; Romeu, Marta] Univ Rovira & Virgili, Fac Med & Hlth Sci, Pharmacol Unit, E-43201 Reus, Spain.
   [Saez, Guillermo; Tormos, Carmen] Univ Valencia, Med Sch Valencia, Dept Biochem & Mol Biol, Valencia, Spain.
   [Bullo, Monica; Salas-Salvado, Jordi] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr 06 03, Madrid, Spain.
   [Masana, Lluis] Univ Rovira & Virgili, Hosp Univ St Joan de Reus, Fac Med & Hlth Sci, Unit Lipids & Atherosclerosis,IISPV, E-43201 Reus, Spain.
   [Masana, Lluis] CIBERDEM Diabet & Associated Metab Dis, Barcelona, Spain.
C3 Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV); Universitat Rovira i Virgili; University of Valencia;
   Instituto de Salud Carlos III; Universitat Rovira i Virgili; Institut
   d'Investigacio Sanitaria Pere Virgili (IISPV); CIBER - Centro de
   Investigacion Biomedica en Red; CIBERDEM
RP Salas-Salvadó, J (corresponding author), Univ Rovira & Virgili, Hosp Univ St Joan de Reus, Fac Med & Hlth Sci, Human Nutr Unit,IISPV, St Llorenc 21, Tarragona 43201, Spain.
EM jordi.salas@urv.cat
RI ROMEU, MARTA/O-7129-2019; MASANA, LUIS/M-7002-2019; Casas,
   Patricia/KBC-3404-2024; Lopez-Uriarte, Patricia/J-2527-2016; Bullo,
   Monica/F-2925-2016; , Patricia Casas-Agustench/M-7762-2014; ROMEU,
   MARTA/A-8468-2014; Salas-Salvado, Jordi/C-7229-2017; Lopez Uriarte,
   Patricia Josefina/D-5481-2011
OI Bullo, Monica/0000-0002-0218-7046; , Patricia
   Casas-Agustench/0000-0003-4424-1087; ROMEU, MARTA/0000-0002-2131-1858;
   Salas-Salvado, Jordi/0000-0003-2700-7459; Saez,
   Guillermo/0000-0002-8164-4048; Lopez Uriarte, Patricia
   Josefina/0000-0002-8459-5368; Masana, Luis/0000-0002-0789-4954
FU International Nut Council, Reus, Spain; Spanish Ministry of Education
   and Science [CICYT-AGL2005-0365]; Spanish Ministry of Health [RTIC
   RD06/0045]; International Nut Council; Generalitat de Catalunya's
   Department of Universities; Research and the Information Society;
   European Social Funds
FX J. Salas-Salvado has received research funding from the International
   Nut Council, Reus, Spain. He is a nonpaid member of the Scientific
   Advisory Board of the International Nut Council. Monica Bullo, Patricia
   Casas-Agustench, Patricia Lopez-Uriarte, Lluis Masana, Rosa Nogues,
   Marta Romeu, Guillermo Saez and Carmen Tormos, no conflict of interest.
   This study was supported by the Spanish Ministry of Education and
   Science (CICYT-AGL2005-0365), Spanish Ministry of Health (RTIC
   RD06/0045), and the International Nut Council. Borges S.A. (Reus, Spain)
   donated the walnuts used in this study. CIBER Fisiopatologia de la
   Obesidad y Nutricion (CIBEROBN) is an initiative of ISCIII. Patricia
   Lopez-Uriarte is the recipient of a predoctoral fellowship from the
   Generalitat de Catalunya's Department of Universities, Research and the
   Information Society and the European Social Funds. We thank Adriana
   Gomez-Flores for her collaboration in the acquisition of the nutritional
   data.
CR AMES BN, 1989, FREE RADICAL RES COM, V7, P121, DOI 10.3109/10715768909087933
   Anderson KJ, 2001, J NUTR, V131, P2837, DOI 10.1093/jn/131.11.2837
   [Anonymous], NUTR METAB CARD 1221
   BERRY EM, 1991, AM J CLIN NUTR, V53, P899, DOI 10.1093/ajcn/53.4.899
   Blomhoff R, 2006, BRIT J NUTR, V96, pS52, DOI 10.1017/BJN20061864
   Brown AA, 2001, AM J CLIN NUTR, V73, P673
   BROWN RK, 1995, FREE RADICAL BIO MED, V18, P801, DOI 10.1016/0891-5849(94)00172-G
   CAO GH, 1993, FREE RADICAL BIO MED, V14, P303, DOI 10.1016/0891-5849(93)90027-R
   CHEN CY, 2008, ASIA PAC J CLIN NUTR, V17
   Cooke MS, 2000, FREE RADICAL RES, V32, P381, DOI 10.1080/10715760000300391
   Cortés B, 2006, J AM COLL CARDIOL, V48, P1666, DOI 10.1016/j.jacc.2006.06.057
   Davis L, 2007, EUR J NUTR, V46, P155, DOI 10.1007/s00394-007-0647-x
   ELOSUA R, 1994, AM J EPIDEMIOL, V139, P1197, DOI 10.1093/oxfordjournals.aje.a116966
   Espinosa O, 2007, FREE RADICAL RES, V41, P546, DOI 10.1080/10715760601164050
   Haddad E, 2006, NUTR RES, V26, P397, DOI 10.1016/j.nutres.2006.06.022
   Hansson GK, 2005, NEW ENGL J MED, V352, P1685, DOI 10.1056/NEJMra043430
   Hargrove RL, 2001, J NUTR, V131, P1758, DOI 10.1093/jn/131.6.1758
   Hyson DA, 2002, J NUTR, V132, P703, DOI 10.1093/jn/132.4.703
   Iwamoto M, 2002, EUR J CLIN NUTR, V56, P629, DOI 10.1038/sj.ejcn.1601400
   Jenkins DJA, 2008, J NUTR, V138, P908, DOI 10.1093/jn/138.5.908
   Jenkins DJA, 2002, CIRCULATION, V106, P1327, DOI 10.1161/01.CIR.0000028421.91733.20
   Jia XD, 2006, NUTR CANCER, V54, P179, DOI 10.1207/s15327914nc5402_4
   Johnson RK, 2000, J AM DIET ASSOC, V100, P769, DOI 10.1016/S0002-8223(00)00225-X
   Kalliomäki TM, 2009, CANCER LETT, V282, P98, DOI 10.1016/j.canlet.2009.03.009
   Kelly JH, 2006, BRIT J NUTR, V96, pS61, DOI 10.1017/BJN20061865
   KLEINVELD HA, 1992, CLIN CHEM, V38, P2066
   Kocyigit A, 2006, NUTR METAB CARDIOVAS, V16, P202, DOI 10.1016/j.numecd.2005.08.004
   Krauss RM, 2000, CIRCULATION, V102, P2284
   Kris-Etherton PM, 1999, AM J CLIN NUTR, V70, p504S, DOI 10.1093/ajcn/70.3.504s
   Li N, 2007, J NUTR, V137, P2717, DOI 10.1093/jn/137.12.2717
   López-Uriarte P, 2009, NUTR REV, V67, P497, DOI 10.1111/j.1753-4887.2009.00223.x
   Martinez-Hervas S, 2008, ATHEROSCLEROSIS, V199, P384, DOI 10.1016/j.atherosclerosis.2007.11.023
   Mukuddem-Petersen J, 2005, J NUTR, V135, P2082, DOI 10.1093/jn/135.9.2082
   Muñoz S, 2001, J LIPID RES, V42, P2069
   Oliva MR, 1997, MOL CARCINOGEN, V18, P232, DOI 10.1002/(SICI)1098-2744(199704)18:4<232::AID-MC7>3.3.CO;2-5
   Ou BX, 2001, J AGR FOOD CHEM, V49, P4619, DOI 10.1021/jf010586o
   REAVEN P, 1993, J CLIN INVEST, V91, P668, DOI 10.1172/JCI116247
   Ros E, 2004, CIRCULATION, V109, P1609, DOI 10.1161/01.CIR.0000124477.91474.FF
   Ros E, 2009, AM J CLIN NUTR, V89, pS1649, DOI 10.3945/ajcn.2009.26736R
   Rozanski A, 2001, CIRCULATION, V103, P2084
   Sáez GT, 2004, AM J HYPERTENS, V17, P809, DOI 10.1016/j.amjhyper.2004.05.022
   Salas-Salvadó J, 2008, ARCH INTERN MED, V168, P2449, DOI 10.1001/archinte.168.22.2449
   Schutte AE, 2006, AM J HYPERTENS, V19, P629, DOI 10.1016/j.amjhyper.2005.12.014
   Spranger T, 1998, CHEM PHYS LIPIDS, V91, P39, DOI 10.1016/S0009-3084(97)00092-3
   Sudheer AR, 2007, TOXICOLOGY, V230, P11, DOI 10.1016/j.tox.2006.10.010
   Tapsell LC, 2004, DIABETES CARE, V27, P2777, DOI 10.2337/diacare.27.12.2777
   Thomas MJ, 1996, J NUTR, V126, pS1058, DOI 10.1093/jn/126.suppl_4.1058S
   Valavanidis A, 2009, J ENVIRON SCI HEAL C, V27, P120, DOI 10.1080/10590500902885684
   Wu LL, 2004, CLIN CHIM ACTA, V339, P1, DOI 10.1016/j.cccn.2003.09.010
   Zambón D, 2000, ANN INTERN MED, V132, P538, DOI 10.7326/0003-4819-132-7-200004040-00039
NR 50
TC 87
Z9 99
U1 1
U2 28
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD JUN
PY 2010
VL 29
IS 3
BP 373
EP 380
DI 10.1016/j.clnu.2009.12.008
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 619EX
UT WOS:000279413100016
PM 20064680
DA 2025-06-11
ER

PT J
AU Arredondo, M
   Fuentes, M
   Jorquera, D
   Candia, V
   Carrasco, E
   Leiva, E
   Mujica, V
   Hertrampf, E
   Pérez, F
AF Arredondo, Miguel
   Fuentes, Marcela
   Jorquera, Denisse
   Candia, Valeria
   Carrasco, Elena
   Leiva, Elba
   Mujica, Veronica
   Hertrampf, Eva
   Perez, Francisco
TI Cross-Talk Between Body Iron Stores and Diabetes: Iron Stores are
   Associated with Activity and Microsatellite Polymorphism of the Heme
   Oxygenase and Type 2 Diabetes
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Type 2 diabetes mellitus; Metabolic syndrome; Iron; Heme oxygenase;
   Microsatellite polymorphism
ID GENE PROMOTER; METABOLIC SYNDROME; SERUM FERRITIN; SUSCEPTIBILITY; RISK;
   EXPRESSION; DNA
AB To assess the relationship between the length of (GT) (n) repeats in HO-1 gene promoter and heme oxygenase (HO) enzymatic activity in mononuclear cells with iron (Fe) stores in type 2 diabetic mellitus (DM2) patients and metabolic syndrome (MS) subjects, we studied 163 patients with DM2, 185 with MS, and 120 controls subjects. We evaluated iron status (hemoglobin and serum Fe, ferritin, and transferrin receptor), and we determined the length of (GT) (n) repeats in HO-1 gene promoter by capillary electrophoresis and HO enzymatic activity in mononuclear cells and assessed the relationship between these results and Fe stores. Only 1/163, 6/185, and 7/120 had iron deficiency anemia in DM2 patients, MS subjects, and controls, respectively. No iron overload (ferritin > 200 mu g/L) was detected in all the subjects studied. DM2 patients had higher iron deposits, total body iron, and heme oxygenase activity (a suggestion of high oxidative stress condition) than MS subjects and controls. In DM2, we found a positive association between serum iron and HO activity. There were no difference in allelic frequency between the three groups; however, among DM2 and MS patients, the frequency of short/medium (SM) genotype of (GT) (n) repetition was increased and medium/medium (MM) genotype of (GT) (n) repetition was lower than controls. These results imply that DM2 patients and individuals with MS carrying SM repeats might have higher susceptibility to develop diabetes consequences. This increased susceptibility could be Fe-mediated oxidative stress.
C1 [Arredondo, Miguel; Fuentes, Marcela; Jorquera, Denisse; Candia, Valeria; Hertrampf, Eva] Univ Chile, Micronutrient Lab, Nutr Inst & Food Technol INTA, Santiago, Chile.
   [Carrasco, Elena] Univ Chile, Fac Med, Dept Med, Diabet Unit, Santiago, Chile.
   [Leiva, Elba; Mujica, Veronica] Univ Talca, Dept Clin Biochem & Immunohematol, Fac Hlth Sci, Talca, Chile.
   [Perez, Francisco] Univ Chile, Fac Med, Dept Nutr, Santiago, Chile.
C3 Universidad de Chile; Universidad de Chile; Universidad de Talca;
   Universidad de Chile
RP Arredondo, M (corresponding author), Univ Chile, Micronutrient Lab, Nutr Inst & Food Technol INTA, El Libano 5524, Santiago, Chile.
EM marredon@inta.cl
RI Perez Rodríguez, Francisco/GRN-8495-2022; Jorquera,
   Denisse/JNR-2853-2023
OI Mujica, Veronica/0000-0001-6290-410X; Jorquera,
   Denisse/0000-0002-8907-6022
FU Fondo Nacional de Ciencia y Tecnologia (FONDECYT), Chile [1051006,
   1085173]
FX This work was supported by Fondo Nacional de Ciencia y Tecnologia
   (FONDECYT) grant # 1051006 and 1085173, Chile.
CR Alissa EM, 2007, J TRACE ELEM MED BIO, V21, P242, DOI 10.1016/j.jtemb.2007.05.002
   Amer Diabet Assoc, 2009, DIABETES CARE, V32, pS13, DOI 10.2337/dc09-S013
   Arredondo M, 2008, BIOL TRACE ELEM RES, V125, P109, DOI 10.1007/s12011-008-8161-4
   Arredondo M, 2007, AM J CLIN NUTR, V86, P1347, DOI 10.1093/ajcn/86.5.1347
   Avery CL, 2006, DIABETOLOGIA, V49, P2329, DOI 10.1007/s00125-006-0375-4
   Bustos P, 2007, NUTR METAB CARDIOVAS, V17, P581, DOI 10.1016/j.numecd.2006.06.001
   Chen YH, 2002, HUM GENET, V111, P1, DOI 10.1007/s00439-002-0769-4
   Cosso L, 2001, FREE RADICAL RES, V34, P189, DOI 10.1080/10715760100300171
   Dandona P, 1996, LANCET, V347, P444, DOI 10.1016/S0140-6736(96)90013-6
   Ford ES, 1999, DIABETES CARE, V22, P1978, DOI 10.2337/diacare.22.12.1978
   Giugliano D, 1996, DIABETES CARE, V19, P257, DOI 10.2337/diacare.19.3.257
   Hirai H, 2003, BLOOD, V102, P1619, DOI 10.1182/blood-2002-12-3733
   Hu FB, 2004, DIABETES, V53, P693, DOI 10.2337/diabetes.53.3.693
   Jiang R, 2004, JAMA-J AM MED ASSOC, V291, P711, DOI 10.1001/jama.291.6.711
   LAVROVSKY Y, 1994, P NATL ACAD SCI USA, V91, P5987, DOI 10.1073/pnas.91.13.5987
   Laybutt DR, 2002, DIABETES, V51, P413, DOI 10.2337/diabetes.51.2.413
   Leiva E, 2007, DIABETES RES CLIN PR, V78, P196, DOI 10.1016/j.diabres.2007.03.018
   Mojiminiyi OA, 2008, NUTR METAB CARDIOVAS, V18, P559, DOI 10.1016/j.numecd.2007.07.007
   National Cholesterol education Program, 2005, NIH PUBL
   NAYLOR LH, 1990, NUCLEIC ACIDS RES, V18, P1595, DOI 10.1093/nar/18.6.1595
   Okinaga S, 1996, BLOOD, V87, P5074, DOI 10.1182/blood.V87.12.5074.bloodjournal87125074
   Witte DL, 1996, CLIN CHIM ACTA, V245, P139, DOI 10.1016/0009-8981(95)06212-2
   Wood RJ, 2001, AM J CLIN NUTR, V73, P638
   Wrede CE, 2006, EUR J ENDOCRINOL, V154, P333, DOI 10.1530/eje.1.02083
   Yamada N, 2000, AM J HUM GENET, V66, P187, DOI 10.1086/302729
NR 25
TC 20
Z9 20
U1 0
U2 8
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD NOV
PY 2011
VL 143
IS 2
BP 625
EP 636
DI 10.1007/s12011-010-8895-7
PG 12
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 829UH
UT WOS:000295609300004
PM 21080099
DA 2025-06-11
ER

PT J
AU Demirbag, R
   Yilmaz, R
   Gur, M
   Celik, H
   Guzel, S
   Selek, S
   Kocyigit, A
AF Demirbag, R.
   Yilmaz, R.
   Gur, M.
   Celik, H.
   Guzel, S.
   Selek, S.
   Kocyigit, A.
TI DNA damage in metabolic syndrome and its association with antioxidative
   and oxidative measurements
SO INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
LA English
DT Article
DE metabolic syndrome; DNA damage; total antioxidant capacity
ID INSULIN-RESISTANCE; STRESS; SEVERITY; GLUCOSE; MARKERS; DISEASE; PLASMA;
   AGE
AB The purpose of this study was to assess DNA damage levels in subjects with metabolic syndrome (MetS). Sixty-five subjects with MetS and 65 controls were enrolled in this study. Levels of DNA damage, total antioxidant capacity (TAC), total peroxide and oxidative stress index (OSI) were measured. We found that DNA damage levels were significantly increased [155.5 (60-264) vs. 93.2 (0-208) arbitrary units; p < 0.001] and TAC levels were significantly decreased in MetS than in control (1.34 +/- 0.27 vs. 55 +/- 0.33 mmol Trolox equivalent/l; p < 0.001). A significant falling trend in TAC levels and a significant rising trend in DNA damage values with the increase in the number of metabolic disturbances (ANOVA p < 0.001 for both) were observed. Total peroxide (30.9 +/- 4.9 vs. 21.3 +/- 2.5 mu mol H2O2/l; p < 0.001) and OSI levels [2.4 (1.3-3.8) vs. 1.4 (0.7-2.3) arbitrary units; p < 0.001] were significantly higher in the subjects with MetS than in controls. We found significant negative correlation between DNA damage and TAC levels in MetS (r = -0.656, p < 0.001) and in control (r = -0.546, p < 0.001). In multiple linear regression analysis, age, body mass index, presence of MetS and number of the componens of MetS were independent predictors of log-transformed DNA damage (p < 0.05, for all). DNA damage is increased in patients with MetS. The increase in DNA damage might be occur because of the increase in the imbalance between the production of oxidants and antioxidant defences in subjects with MetS.
C1 Harran Univ, Fac Med, Dept Cardiol, Sanliurfa, Turkey.
   Harran Univ, Fac Med, Dept Clin Biochem, Sanliurfa, Turkey.
C3 Harran University; Harran University
RP Demirbag, R (corresponding author), PK 112, Sanliurfa, Turkey.
EM rdemirbag@yahoo.com
RI Kocyigit, Abdurrahim/P-8685-2019; ÇELİK, HACİ/AAL-5433-2020; Demirbag,
   Recep/Z-2369-2019; SELEK, Sahabettin/N-9323-2019
OI Demirbag, Recep/0000-0001-7831-2715; SELEK,
   Sahabettin/0000-0003-1235-3957
CR Andreassi MG, 2003, MUTAT RES-REV MUTAT, V543, P67, DOI 10.1016/S1383-5742(02)00089-3
   Andreassi MG, 2002, J AM COLL CARDIOL, V40, P862, DOI 10.1016/S0735-1097(02)02042-9
   Beckman KB, 1998, PHYSIOL REV, V78, P547, DOI 10.1152/physrev.1998.78.2.547
   Beltowski J, 2000, J PHYSIOL PHARMACOL, V51, P883
   Bonnefont-Rousselot D, 2002, CURR OPIN CLIN NUTR, V5, P561, DOI 10.1097/00075197-200209000-00016
   Botto N, 2002, CORONARY ARTERY DIS, V13, P269, DOI 10.1097/00019501-200208000-00004
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Collins AR, 1999, BIOESSAYS, V21, P238, DOI 10.1002/(SICI)1521-1878(199903)21:3<238::AID-BIES8>3.0.CO;2-3
   Demirbag R, 2005, MUTAT RES-FUND MOL M, V578, P298, DOI 10.1016/j.mrfmmm.2005.05.005
   Demirbag R, 2005, CAN J CARDIOL, V21, P851
   Demirbag R, 2005, MUTAT RES-FUND MOL M, V570, P197, DOI 10.1016/j.mrfmmm.2004.11.003
   Erel O, 2004, CLIN BIOCHEM, V37, P112, DOI 10.1016/j.clinbiochem.2003.10.014
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Goukassian D, 2000, FASEB J, V14, P1325, DOI 10.1096/fj.14.10.1325
   Grundy SM, 1999, AM J CARDIOL, V83, p25F
   HALLIWELL B, 1994, LANCET, V344, P721, DOI 10.1016/S0140-6736(94)92211-X
   Harangi M, 2002, MUTAT RES-GEN TOX EN, V513, P17, DOI 10.1016/S1383-5718(01)00285-6
   Inoguchi T, 2000, DIABETES, V49, P1939, DOI 10.2337/diabetes.49.11.1939
   Kendall DM, 2002, AM J MANAG CARE, V8, pS635
   Koracevic D, 2001, J CLIN PATHOL, V54, P356, DOI 10.1136/jcp.54.5.356
   Lee KU, 2001, DIABETES RES CLIN PR, V54, pS29, DOI 10.1016/S0168-8227(01)00332-1
   Lipinski B, 2001, J DIABETES COMPLICAT, V15, P203, DOI 10.1016/S1056-8727(01)00143-X
   Maritim AC, 2003, J BIOCHEM MOL TOXIC, V17, P24, DOI 10.1002/jbt.10058
   Marnett LJ, 2000, CARCINOGENESIS, V21, P361, DOI 10.1093/carcin/21.3.361
   Meigs JB, 2002, AM J MANAG CARE, V8, pS283
   Negishi H, 2001, J HYPERTENS, V19, P529, DOI 10.1097/00004872-200103001-00002
   Paolisso G, 1999, EUR J CLIN INVEST, V29, P758
   Riccardi G, 2004, EUR J NUTR, V43, P7, DOI 10.1007/s00394-004-1202-7
   SINGH NP, 1988, EXP CELL RES, V175, P184, DOI 10.1016/0014-4827(88)90265-0
   Trevisan M, 2001, AM J EPIDEMIOL, V154, P348, DOI 10.1093/aje/154.4.348
   Young IS, 2001, J CLIN PATHOL, V54, P176, DOI 10.1136/jcp.54.3.176
NR 31
TC 59
Z9 64
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-5031
EI 1742-1241
J9 INT J CLIN PRACT
JI Int. J. Clin. Pract.
PD OCT
PY 2006
VL 60
IS 10
BP 1187
EP 1193
DI 10.1111/j.1742-1241.2006.01042.x
PG 7
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA 082RG
UT WOS:000240404300011
PM 16981963
DA 2025-06-11
ER

PT J
AU Efthymiou, D
   Zekakos, DX
   Papatriantafyllou, E
   Ziagkas, E
   Petrelis, AN
   Vassilopoulou, E
AF Efthymiou, Dimitris
   Zekakos, Dimitrios X.
   Papatriantafyllou, Evangelia
   Ziagkas, Efthimis
   Petrelis, Alexandros N.
   Vassilopoulou, Emilia
TI Gait Alterations in the Prediction of Metabolic Syndrome in Patients
   With Schizophrenia: A Pilot Study With PODOSmart ® Insoles
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE antipsychotics; metabolic syndrome; gait analysis; inflammation;
   gaitline; speed; weight; PODOSmart (R)
ID C-REACTIVE PROTEIN; WEIGHT-GAIN; ANTIPSYCHOTICS; DISORDERS; ANKLE;
   DISTURBANCES; OUTPATIENTS; MECHANISMS; PSYCHOSIS; CHILDREN
AB Background:& nbsp;Second-generation antipsychotics (APs) are associated with metabolic syndrome (MetS), characterized by abnormal pro-inflammatory cytokine production and oxidative stress due to the reduced antioxidant systems, and neurological effects, including mobility impairment. This pilot study investigated relationships between inflammatory-metabolic biomarkers, MetS and gait alterations in patients with psychosis treated with APs.& nbsp;Methods:& nbsp;Patients with psychosis treated with APs, 20 with MetS (MPS group) and 20 without MetS (PS group) were studied, usinganthropometric data, blood measurements and gait analysis performed with the PODOSmart (R) gait analysis device.& nbsp;Results and Discussion:& nbsp;The MPS group had significantly higher mean body mass index (BMI) and arterial blood pressure (BP) than the PS group. PODOSmart (R) gait analysis recorded significant differences between groups in pronation-supination at Heel Off (HO), gaitline HO and gaitline Toe Off (TO). Multifactorial elastic net regression models demonstrated significant association with MetS of inflammatory markers, specific AP2 treatment, gender, age; BMI; BP and smoking (accuracy lambda = 0.08), and in relation to gait parameters (accuracy lambda = 0.750), the three pronation- supination variables, i.e., at HO, flat foot in (AP2 related) and TO, and propulsion speed. The gait parameters were at the edges of the model, thus indicating a more significant role of these parameters compared to the other clinical variables. Early diagnosis of MetS in patients with schizophrenia via identification of gait alterations can be a screening measure for serious cardiovascular complications related to psychosis and APs, to enable timely dietary intervention that can control the pro-inflammatory state and reduce oxidative stress.
C1 [Efthymiou, Dimitris] Aristotle Univ Thessaloniki, Sch Med, Dept Psychiat, Div Neurosci, Thessaloniki, Greece.
   [Zekakos, Dimitrios X.; Petrelis, Alexandros N.] Digitsole SAS, Nancy, France.
   [Papatriantafyllou, Evangelia; Vassilopoulou, Emilia] Int Hellen Univ, Dept Nutr Sci & Dietet, Thessaloniki, Greece.
   [Ziagkas, Efthimis] Aristotle Univ Thessaloniki, Lab Motor Behav, Thessaloniki, Greece.
C3 Aristotle University of Thessaloniki; International Hellenic University;
   Aristotle University of Thessaloniki
RP Vassilopoulou, E (corresponding author), Int Hellen Univ, Dept Nutr Sci & Dietet, Thessaloniki, Greece.
EM vassilopoulouemilia@gmail.com
RI ; Vassilopoulou, Emilia/AAE-7270-2021
OI Petrelis, Alexandros/0000-0001-9156-4896; Vassilopoulou,
   Emilia/0000-0002-2665-5908
FU Digitsole SAS, Nancy, France
FX This research was funded by Digitsole SAS, Nancy, France.
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Anderson FC, 2004, J BIOMECH, V37, P731, DOI 10.1016/j.jbiomech.2003.09.018
   Andreassen OA, 2017, AM J PSYCHIAT, V174, P616, DOI 10.1176/appi.ajp.2017.17040409
   [Anonymous], GAIT PATTERN AN OVER
   Bak M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094112
   Barton BB, 2020, EXPERT OPIN DRUG SAF, V19, P295, DOI 10.1080/14740338.2020.1713091
   Bozymski KM, 2018, COMMUNITY MENT HLT J, V54, P717, DOI 10.1007/s10597-017-0203-y
   Bradley AJ, 2010, J PSYCHOPHARMACOL, V24, P91, DOI 10.1177/1359786810385491
   Caroff SN, 2011, NEUROL CLIN, V29, P127, DOI 10.1016/j.ncl.2010.10.002
   Chadda RK, 2013, J PHARMACOL PHARMACO, V4, P176, DOI 10.4103/0976-500X.114596
   Chen JH, 2018, INT J CLIN EXP PATHO, V11, P5969
   Cuervo M, 1996, J PEDIATR ORTHOP B, V5, P35, DOI 10.1097/01202412-199605010-00007
   Dehelean L, 2019, ACTA ENDOCRINOL-BUCH, V15, P342, DOI 10.4183/aeb.2019.342
   del Campo A, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00144
   DSouza R. S., 2021, EXTRAPYRAMIDAL SYMPT
   Eskelinen S, 2015, NORD J PSYCHIAT, V69, P339, DOI 10.3109/08039488.2014.983544
   Feldman R, 2019, HUM MOVEMENT SCI, V67, DOI 10.1016/j.humov.2019.102513
   Fernández-Garcia JC, 2013, CURR VASC PHARMACOL, V11, P906, DOI 10.2174/15701611113116660175
   Fisher E, 2020, TRANSL PSYCHIAT, V10, DOI 10.1038/s41398-020-00927-x
   Flyckt L, 1999, PSYCHIAT RES, V86, P113, DOI 10.1016/S0165-1781(99)00027-X
   Pato CM, 2017, REV PSIQUIATR SALUD, V10, P38, DOI 10.1016/j.rpsm.2016.09.003
   Goff DC, 2021, JAMA-J AM MED ASSOC, V325, P175, DOI 10.1001/jama.2020.19048
   Hailey D, 2000, DISABIL REHABIL, V22, P275, DOI 10.1080/096382800296737
   Harrow M, 2022, PSYCHOL MED, V52, P2681, DOI 10.1017/S0033291720004778
   Harvey PD, 2012, WORLD PSYCHIATRY, V11, P73, DOI 10.1016/j.wpsyc.2012.05.004
   Howell AM, 2013, IEEE T BIO-MED ENG, V60, P3284, DOI 10.1109/TBME.2013.2250972
   Jacomb I, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.02230
   MALHOTRA D, 1984, J BONE JOINT SURG BR, V66, P381, DOI 10.1302/0301-620X.66B3.6373777
   MANSOUR JM, 1982, J BIOMECH, V15, P51, DOI 10.1016/0021-9290(82)90034-3
   Manu P, 2015, ACTA PSYCHIAT SCAND, V132, P97, DOI 10.1111/acps.12445
   MENA D, 1981, J BIOMECH, V14, P823, DOI 10.1016/0021-9290(81)90010-5
   Metcalf SA, 2017, BRAIN BEHAV IMMUN, V59, P253, DOI 10.1016/j.bbi.2016.09.008
   Miller BJ, 2013, BRAIN BEHAV IMMUN, V31, P82, DOI 10.1016/j.bbi.2012.08.016
   Mondelli V, 2015, SCHIZOPHRENIA BULL, V41, P1162, DOI 10.1093/schbul/sbv028
   Nonnekes J, 2020, NEUROLOGY, V94, P1093, DOI 10.1212/WNL.0000000000009649
   Okoro CA, 2006, BMC PUBLIC HEALTH, V6, DOI 10.1186/1471-2458-6-282
   Osimo EF, 2018, PSYCHONEUROENDOCRINO, V91, P226, DOI 10.1016/j.psyneuen.2018.02.031
   Ozdemir Meltem, 2019, Radiol Case Rep, V14, P1027, DOI 10.1016/j.radcr.2019.05.035
   Peluso MJ, 2012, BRIT J PSYCHIAT, V200, P387, DOI 10.1192/bjp.bp.111.101485
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Perry J, 2010, GAIT ANALYSIS: NORMAL AND PATHOLOGICAL FUNCTION, SECOND EDITION, P1
   Pillinger T, 2020, LANCET PSYCHIAT, V7, P64, DOI 10.1016/S2215-0366(19)30416-X
   PISTOIA F, 1987, SKELETAL RADIOL, V16, P447, DOI 10.1007/BF00350538
   Presta V, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0245661
   Putzhammer A, 2005, PSYCHIAT CLIN NEUROS, V59, P303, DOI 10.1111/j.1440-1819.2005.01375.x
   Reynolds GP, 2017, J PSYCHOPHARMACOL, V31, P1430, DOI 10.1177/0269881117722987
   Saggio G, 2021, IEEE SENS J, V21, P1616, DOI 10.1109/JSEN.2020.3016642
   Schmitt A, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00690
   Schneider-Thoma J, 2018, LANCET PSYCHIAT, V5, P653, DOI 10.1016/S2215-0366(18)30177-9
   Simon SR, 2004, J BIOMECH, V37, P1869, DOI 10.1016/j.jbiomech.2004.02.047
   Spertus J, 2018, NPJ SCHIZOPHR, V4, DOI 10.1038/s41537-018-0053-9
   Stevens Jonathan R, 2014, Prim Care Companion CNS Disord, V16, DOI 10.4088/PCC.13f01514
   Stevens PM, 1999, J PEDIATR ORTHOPED, V19, P515, DOI 10.1097/00004694-199907000-00018
   Tandon R, 2020, ANN GEN PSYCHIATR, V19, DOI 10.1186/s12991-020-00292-5
   Tune JD, 2017, TRANSL RES, V183, P57, DOI 10.1016/j.trsl.2017.01.001
   van Beers RJ, 2013, J NEUROPHYSIOL, V109, P969, DOI 10.1152/jn.00706.2012
   Vassilopoulou E, 2021, J PERS MED, V11, DOI 10.3390/jpm11111189
   Ventriglio A, 2019, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00744
   Veronese N, 2018, J AM MED DIR ASSOC, V19, P981, DOI 10.1016/j.jamda.2018.06.007
NR 59
TC 4
Z9 4
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JAN 27
PY 2022
VL 13
AR 756600
DI 10.3389/fpsyt.2022.756600
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA YW9GZ
UT WOS:000753720700001
PM 35153872
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pourgholi, L
   Pourgholi, F
   Ziaee, S
   Goodarzynejad, H
   Hosseindokht, M
   Boroumand, M
   Mandegary, A
AF Pourgholi, Leyla
   Pourgholi, Fatemeh
   Ziaee, Shayan
   Goodarzynejad, Hamidreza
   Hosseindokht, Maryam
   Boroumand, Mohammadali
   Mandegary, Ali
TI The association between CYBA gene C242T variant and risk of
   metabolic syndrome
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE C242T polymorphism; CYBA gene; metabolic syndrome; NADPH oxidase;
   phoxp22; ROS
ID P22 PHOX GENE; OXIDATIVE STRESS; NAD(P)H OXIDASE; POLYMORPHISM;
   PREVALENCE; P22(PHOX); DISEASE; POPULATION
AB Background Both inflammation and oxidative stress may contribute to pathogenesis of metabolic syndrome (MetS). The C242T polymorphism (rs4673) in the CYBA gene, as the main components of NAD (P) H oxidase, causes inter-individual variability in the enzyme activity. We aimed to investigate the association between this polymorphism with MetS and its components. Methods Two hundred nine patients with MetS and 232 controls were included in this study. MetS was defined based on NCEP ATP-III A criteria with some modifications. The C242T polymorphism within CYBA gene was determined by using PCR-based restriction fragment length polymorphism (PCR-RFLP) method. Results After applying a multiple logistic regression model with adjusting for potential confounders of MetS including, age, sex, body mass index, hypertension, used medications, and diabetes mellitus, C242T polymorphism was found to be associated with the presence of MetS in men but not in the total population or in women. T allele as compared to C allele was associated with decreased odds of MetS in men (adjusted OR = 0.42, 95% CI = 0.24-0.74;P = .003), but not in women (adjusted OR = 1.03, 95% CI = 0.07-1.61;P = .890), or in the total population (adjusted OR = 0.72, 95% CI = 0.51-1.02;P = .063). Conclusion This study shows that T allele of C242T polymorphism in CYBA gene is protective against MetS in Iranian men but not in women. Further cohort studies with larger sample size in subgroups of men and women are required to confirm such association in other racial or ethnic group.
C1 [Pourgholi, Leyla; Ziaee, Shayan; Hosseindokht, Maryam; Boroumand, Mohammadali] Univ Tehran Med Sci, Tehran Heart Ctr, Dept Pathol & Lab Med, Tehran, Iran.
   [Pourgholi, Leyla; Mandegary, Ali] Kerman Univ Med Sci, Sch Pharm, Dept Pharmacol & Toxicol, POB 7616911319, Kerman, Iran.
   [Pourgholi, Fatemeh] Tabriz Univ Med Sci, Fac Med, Dept Immunol, Tabriz, Iran.
   [Goodarzynejad, Hamidreza] Univ Tehran Med Sci, Tehran Heart Ctr, Dept Cardiac Res, Tehran, Iran.
   [Mandegary, Ali] Kerman Univ Med Sci, Physiol Res Ctr, Inst Neuropharmacol, Kerman, Iran.
C3 Tehran University of Medical Sciences; Kerman University of Medical
   Sciences; Tabriz University of Medical Science; Tehran University of
   Medical Sciences; Kerman University of Medical Sciences
RP Mandegary, A (corresponding author), Kerman Univ Med Sci, Sch Pharm, Dept Pharmacol & Toxicol, POB 7616911319, Kerman, Iran.; Boroumand, M (corresponding author), Univ Tehran Med Sci, Tehran Heart Ctr, Dept Clin Pathol & Lab Med, POB 1411713138, Tehran, Iran.
EM maboroumand@yahoo.com; alimandegary@kmu.ac.ir
RI Goodarzynejad, Hamidreza/AFJ-2865-2022; Mandegary, Ali/O-9809-2017
OI Mandegary, Ali/0000-0002-1065-9349
CR Azizi F, 2003, DIABETES RES CLIN PR, V61, P29, DOI 10.1016/S0168-8227(03)00066-4
   Biberstine-Kinkade KJ, 2002, J BIOL CHEM, V277, P30368, DOI 10.1074/jbc.M203993200
   Biberstine-Kinkade KJ, 2001, J BIOL CHEM, V276, P31105, DOI 10.1074/jbc.M103327200
   Bonomini F, 2015, AGING DIS, V6, P109, DOI 10.14336/AD.2014.0305
   Delavari A, 2009, DIABETES CARE, V32, P1092, DOI 10.2337/dc08-1800
   DINAUER MC, 1990, J CLIN INVEST, V86, P1729, DOI 10.1172/JCI114898
   Drummond GR, 2011, NAT REV DRUG DISCOV, V10, P453, DOI 10.1038/nrd3403
   Fan M, 2006, AM HEART J, V152, P538, DOI 10.1016/j.ahj.2006.02.018
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Ge JY, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031926
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Harris MF, 2013, AUST FAM PHYSICIAN, V42, P524
   Hayaishi-Okano R, 2003, DIABETES CARE, V26, P458, DOI 10.2337/diacare.26.2.458
   Hayaishi-Okano Rieko, 2002, J Atheroscler Thromb, V9, P200
   Helal O, 2011, NUTR METAB CARDIOVAS, V21, P665, DOI 10.1016/j.numecd.2010.01.004
   Ilkun O, 2013, CURR PHARM DESIGN, V19, P4806, DOI 10.2174/1381612811319270003
   Inoue N, 1998, CIRCULATION, V97, P135, DOI 10.1161/01.CIR.97.2.135
   José GS, 2008, CLIN SCI, V114, P173, DOI 10.1042/CS20070130
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Mandegary A, 2015, TRANSPL IMMUNOL, V32, P46, DOI 10.1016/j.trim.2014.08.004
   Yubero-Serrano EM, 2013, EXP MOL MED, V45, DOI 10.1038/emm.2013.53
   Mohebbi I, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031790
   Noshad S, 2017, J DIABETES, V9, P518, DOI 10.1111/1753-0407.12438
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Pourgholi L, 2016, TOXICOL APPL PHARM, V309, P37, DOI 10.1016/j.taap.2016.08.026
   Rousset F, 2020, REDOX BIOL, V30, DOI 10.1016/j.redox.2020.101434
   Schreiber R, 2012, DIABETIC MED, V29, pE55, DOI 10.1111/j.1464-5491.2012.03594.x
   Shahbazian H, 2013, J DIABETES METAB DIS, V12, DOI 10.1186/2251-6581-12-11
   Soccio M, 2005, EUR J CLIN INVEST, V35, P305, DOI 10.1111/j.1365-2362.2005.01500.x
   Stancáková A, 2014, REV ENDOCR METAB DIS, V15, P243, DOI 10.1007/s11154-014-9293-9
   UshioFukai M, 1996, J BIOL CHEM, V271, P23317, DOI 10.1074/jbc.271.38.23317
   Xu QM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0084251
NR 32
TC 4
Z9 4
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD SEP
PY 2020
VL 50
IS 9
AR e13275
DI 10.1111/eci.13275
EA JUL 2020
PG 7
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA NG3XQ
UT WOS:000553214700001
PM 32406080
DA 2025-06-11
ER

PT J
AU Akçay, NC
   Ömeroglu, S
   Dizakar, SÖA
   Kavutçu, M
   Türkoglu, I
   Esmekaya, MA
   Peker, TV
AF Akcay, Neslihan Coskun
   Omeroglu, Suna
   Dizakar, Saadet Ozen Akarca
   Kavutcu, Mustafa
   Turkoglu, Ismail
   Esmekaya, Meric Arda
   Peker, Tuncay Veysel
TI The effects of melatonin on possible damage that will occur on
   adipocytokines and liver tissue by coadministration of fructose and
   bisphenol a (BPA)
SO ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
LA English
DT Article
DE Bisphenol A; Melatonin; Metabolic syndrome; Liver; Adipocytokine;
   Fructose
ID OXIDATIVE STRESS; VISCERAL ADIPOSITY; METABOLIC SYNDROME; DIETARY
   FRUCTOSE; ADIPONECTIN; PREVENTS; CELL; CONSUMPTION; INHIBITION;
   MECHANISMS
AB BPA, one of the environmental endocrine disruptors, and fructose, reason of liver steatosis which is frequently encountered in the daily diet, contribute to the formation of metabolic syndrome (MetS). This study examines the possible effects of concurrent fructose and BPA administration on MetS and determines the effects of melatonin on this process. In the seven identified groups, a total of forty-two adult male Sprague Dawley rats were treated by following fructose, BPA, and melatonin amounts, separately and together: group 1 (control), group 2 (10% aqueous fructose), group 3 (25 mg/kg BPA), group 4 (10% fructose + 25 mg/kg BPA), group 5 (10% fructose + 20 mg/kg melatonin), group 6 (25 mg/kg BPA + 20 mg/kg melatonin), and group 7 (10% fructose + 25 mg/kg BPA + 20 mg/kg melatonin). At the end of 60 days, histochemical, immunohistochemical, and biochemical procedures were performed on liver tissue. As a result, it was seen that BPA and fructose + BPA induced morphological alteration and inflammation and increased intracellular lipid quantity and amount of collagen and reticular fibers. The percentage of apoptotic liver cells stained by annexin V-FITC/PI was lower in group 7 compared to the group 4 (p < 0,001) and also in group 6 compared to the group 3 (p = 0.014). Both BPA and fructose application caused an increase in lipid peroxidation level due to the increase of oxidative stress. Application of melatonin induced antioxidant enzyme activity and reduced lipid peroxidation level. Our results indicate that fructose and BPA administration triggered the formation of MetS, whereas melatonin healed these variations, although not entirely.
C1 [Akcay, Neslihan Coskun] Hacettepe Univ, Dept Obstet & Gynecol, Vitro Fertilizat Unit, Fac Med, 2th Floor, TR-06230 Ankara, Turkey.
   [Omeroglu, Suna; Dizakar, Saadet Ozen Akarca; Turkoglu, Ismail] Gazi Univ, Dept Histol & Embryol, Fac Med, Deans Bldg,4th Floor, TR-06560 Ankara, Turkey.
   [Kavutcu, Mustafa] Gazi Univ, Dept Biochem, Fac Med, Deans Bldg,5th Floor, TR-06560 Ankara, Turkey.
   [Esmekaya, Meric Arda] Gazi Univ, Dept Biophys, Fac Med, Deans Bldg,5th Floor, TR-06560 Ankara, Turkey.
   [Peker, Tuncay Veysel] Gazi Univ, Dept Anat, Fac Med, Deans Bldg,2th Floor, TR-06560 Ankara, Turkey.
C3 Hacettepe University; Gazi University; Gazi University; Gazi University;
   Gazi University
RP Akçay, NC (corresponding author), Hacettepe Univ, Dept Obstet & Gynecol, Vitro Fertilizat Unit, Fac Med, 2th Floor, TR-06230 Ankara, Turkey.
EM neslihancoskun@hacettepe.edu.tr; sunaer@gazi.edu.tr;
   ozenakarca@gmail.com; kavutcu@gazi.edu.tr; ismailt.turkoglu@gmail.com;
   mericarda@yahoo.com; tpeker@gazi.edu.tr
RI Türkoğlu, İsmail/JRY-1673-2023; DİZAKAR, Saadet Özen/AAA-1367-2021;
   COSKUN AKCAY, Neslihan/JZS-9230-2024; Peker, tuncay/ABI-3436-2020
OI Turkoglu, Ismail/0000-0002-0567-5459
FU Scientific Researches Project Unit at Gazi University [01/2015-06]
FX This study was funded by the Scientific Researches Project Unit at Gazi
   University (Project number 01/2015-06).
CR AEBI H, 1984, METHOD ENZYMOL, V105, P121
   Agil A, 2015, J PINEAL RES, V59, P70, DOI 10.1111/jpi.12241
   Bray GA, 2004, AM J CLIN NUTR, V79, P537
   Buechler C, 2011, WORLD J GASTROENTERO, V17, P2801, DOI 10.3748/wjg.v17.i23.2801
   Cardinali DR, 2011, NEUROENDOCRINOLOGY, V93, P133, DOI 10.1159/000324699
   Castro MC, 2012, CLIN SCI, V123, P681, DOI 10.1042/CS20110665
   Dallio M, 2018, ALIMENT PHARM THER, V47, P826, DOI 10.1111/apt.14499
   Deng WS, 2016, EXP THER MED, V11, P1955, DOI 10.3892/etm.2016.3160
   Deng YF, 2010, ANN NY ACAD SCI, V1212, pE1, DOI 10.1111/j.1749-6632.2010.05875.x
   Durak I, 1996, J CLIN LAB ANAL, V10, P17, DOI 10.1002/(SICI)1098-2825(1996)10:1<17::AID-JCLA4>3.3.CO;2-6
   Emila S, 2013, ROLE BISPHENOL HUMAN, V3, P1
   Esmekaya MA, 2013, CELL BIOCHEM BIOPHYS, V67, P1371, DOI 10.1007/s12013-013-9669-6
   Girard A, 2006, NUTRITION, V22, P758, DOI 10.1016/j.nut.2006.05.006
   Guérin P, 2001, HUM REPROD UPDATE, V7, P175, DOI 10.1093/humupd/7.2.175
   HABIG WH, 1974, J BIOL CHEM, V249, P7130
   Han YH, 2008, ONCOL REP, V20, P689, DOI 10.3892/or_00000061
   Havel PJ, 2005, NUTR REV, V63, P133, DOI [10.1301/nr.2005.may.133-157, 10.1111/j.1753-4887.2005.tb00132.x]
   Henriques Mônica Souza de Miranda, 2014, J. Bras. Patol. Med. Lab., V50, P136, DOI 10.5935/1676-2444.20140007
   HOCKENBERY D, 1990, NATURE, V348, P334, DOI 10.1038/348334a0
   Hüttemann M, 2011, MITOCHONDRION, V11, P369, DOI 10.1016/j.mito.2011.01.010
   Hugo ER, 2008, ENVIRON HEALTH PERSP, V116, P1642, DOI 10.1289/ehp.11537
   Hussein RM, 2013, LIFE SCI J, V10, P1050
   Jarukamjorn K, 2016, SCIENTIFICA, V2016, DOI 10.1155/2016/5029414
   Koziróg M, 2011, J PINEAL RES, V50, P261, DOI 10.1111/j.1600-079X.2010.00835.x
   Li WF, 2016, FOOD FUNCT, V7, P2420, DOI 10.1039/c6fo00038j
   Lozano I, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0074-1
   Ma H, 2015, ANN HEPATOL, V14, P108, DOI 10.1016/S1665-2681(19)30807-5
   Maithili Karpaga Selvi Nachimuthu, 2015, Sci Pharm, V83, P159, DOI 10.3797/scipharm.1408-16
   Miller A, 2008, CURR OPIN GASTROEN, V24, P204, DOI 10.1097/MOG.0b013e3282f3f4c4
   Palmieri VO, 2006, J NUTR, V136, P3022, DOI 10.1093/jn/136.12.3022
   Prokop Z, 2004, REACT FUNCT POLYM, V60, P77, DOI 10.1016/j.reactfunctpolym.2004.02.013
   Roche HM, 2005, P NUTR SOC, V64, P371, DOI 10.1079/PNS2005445
   Rogers JA, 2013, MOL IMMUNOL, V53, P421, DOI 10.1016/j.molimm.2012.09.013
   Rubin BS, 2011, J STEROID BIOCHEM, V127, P27, DOI 10.1016/j.jsbmb.2011.05.002
   Rutledge AC, 2007, NUTR REV, V65, pS13, DOI 10.1301/nr.2007.jun.S13-S23
   Sahin I, 2011, MOL CELL BIOCHEM, V355, P299, DOI 10.1007/s11010-011-0867-5
   Sangai NP, 2014, TOXICOL IND HEALTH, V30, P581, DOI 10.1177/0748233712457438
   Sheehan DM, 2000, P SOC EXP BIOL MED, V224, P57, DOI 10.1046/j.1525-1373.2000.22401.x
   Smaili SS, 2000, J BIOENERG BIOMEMBR, V32, P35, DOI 10.1023/A:1005508311495
   Song ZY, 2008, HEPATOLOGY, V47, P867, DOI 10.1002/hep.22074
   Stanhope KL, 2008, CURR OPIN LIPIDOL, V19, P16, DOI 10.1097/MOL.0b013e3282f2b24a
   Sumit JS, 2007, BIOCH CELL BIOL, V83, P86
   Suthar H, 2014, INT J ADV LIFE SCI, V7, P11
   Tappy L, 2010, NUTRITION, V26, P1044, DOI 10.1016/j.nut.2010.02.014
   VANYE TM, 1993, J SURG RES, V55, P553, DOI 10.1006/jsre.1993.1183
   Xia W, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0090443
   Zhou L, 2015, INT IMMUNOPHARMACOL, V29, P462, DOI 10.1016/j.intimp.2015.10.012
NR 47
TC 10
Z9 10
U1 1
U2 16
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0944-1344
EI 1614-7499
J9 ENVIRON SCI POLLUT R
JI Environ. Sci. Pollut. Res.
PD MAY
PY 2020
VL 27
IS 14
BP 16231
EP 16245
DI 10.1007/s11356-020-08041-7
EA MAR 2020
PG 15
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA LP3LH
UT WOS:000517720600018
PM 32124283
DA 2025-06-11
ER

PT J
AU Morrison, FG
   Logue, MW
   Guetta, R
   Maniates, H
   Stone, A
   Schichman, SA
   McGlinchey, RE
   Milberg, WP
   Miller, MW
   Wolf, EJ
AF Morrison, Filomene G.
   Logue, Mark W.
   Guetta, Rachel
   Maniates, Hannah
   Stone, Annjanette
   Schichman, Steven A.
   McGlinchey, Regina E.
   Milberg, William P.
   Miller, Mark W.
   Wolf, Erika J.
TI Investiption of bidirectional longitudinal associations between advanced
   epigenetic age and peripheral biomarkers of inflammation and metabolic
   syndrome
SO AGING-US
LA English
DT Article
DE epigenetic age; DNA methylation age; longitudinal; C-reactive protein;
   metabolic syndrome
ID POSTTRAUMATIC-STRESS-DISORDER; DNA METHYLATION AGE; ALL-CAUSE MORTALITY;
   PTSD; RISK; POPULATION; SENESCENCE; DISEASE; CANCER; LOAD
AB Epigenetic age estimations based on DNA methylation (DNAm) can predict human chronological age with a high level of accuracy. These DNAm age algorithms can also be used to index advanced cellular age, when estimated DNAm age exceeds chronological age. Advanced DNAm age has been associated with several diseases and metabolic and inflammatory pathology, but the causal direction of this association is unclear. The goal of this study was to examine potential bidirectional associations between advanced epigenetic age and metabolic and inflammatory markers over time in a longitudinal cohort of 179 veterans with a high prevalence of posttraumatic stress disorder (PTSD) who were assessed over the course of two years. Analyses focused on two commonly investigated metrics of advanced DNAm age derived from the Horvath (developed across multiple tissue types) and Hannum (developed in whole blood) DNAm age algorithms. Results of cross-lagged panel models revealed that advanced Hannum DNAm age at Time 1 (T1) was associated with increased (i.e., accounting for T1 levels) metabolic syndrome (MetS) severity at Time 2 (T2; p = < 0.001). This association was specific to worsening lipid panels and indicators of abdominal obesity (p = 0.001). In contrast, no baseline measures of inflammation or metabolic pathology were associated with changes in advanced epigenetic age over time. No associations emerged between advanced Horvath DNAm age and any of the examined biological parameters. Results suggest that advanced epigenetic age, when measured using an algorithm developed in whole blood, may be a prognostic marker of pathological metabolic processes. This carries implications for understanding pathways linking advanced epigenetic age to morbidity and mortality.
C1 [Morrison, Filomene G.; Logue, Mark W.; Guetta, Rachel; Maniates, Hannah; Miller, Mark W.; Wolf, Erika J.] VA Boston Healthcare Syst, Natl Ctr, PTSD, Boston, MA 02130 USA.
   [Morrison, Filomene G.; Logue, Mark W.; Miller, Mark W.; Wolf, Erika J.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA.
   [Logue, Mark W.] Boston Univ, Sch Med, Biomed Genet, Boston, MA 02118 USA.
   [Stone, Annjanette; Schichman, Steven A.] Cent Arkansas Vet Healthcare Syst, Res Serv, Pharmacogen Anal Lab, Little Rock, AR 72205 USA.
   [McGlinchey, Regina E.; Milberg, William P.] VA Boston Healthcare Syst, Geriatr Res Educ & Clin Ctr, Boston, MA 02130 USA.
   [McGlinchey, Regina E.; Milberg, William P.] VA Boston Healthcare Syst, Translat Res Ctr TBI & Stress Disorders, Boston, MA 02130 USA.
   [McGlinchey, Regina E.; Milberg, William P.] Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; Boston University; Boston University; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); Central
   Arkansas Veterans Healthcare System; Geriatric Research Education &
   Clinical Center; Harvard University; Harvard University Medical
   Affiliates; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Boston Healthcare System; Harvard University;
   Harvard University Medical Affiliates; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); VA Boston Healthcare
   System; Harvard University; Harvard Medical School
RP Wolf, EJ (corresponding author), VA Boston Healthcare Syst, Natl Ctr, PTSD, Boston, MA 02130 USA.; Wolf, EJ (corresponding author), Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA.
EM Erika.Wolf@va.gov
RI Miller, Mark/G-7322-2011; McGlinchey, Regina/R-1971-2016
OI Wolf, Erika/0000-0003-2666-2435; Guetta, Rachel/0000-0002-7271-9917
FU Merit Review Award from United States (U.S.) Department of Veterans
   Affairs Clinical Sciences R&D (CSRD) Service [I01 CX-001276-01];
   Presidential Early Career Award for Scientists and Engineers (PECASE
   2013A); NIA [R0350204413]; NIMH [R21MH102834]; Translational Research
   Center for TBI and Stress Disorders (TRACTS), a VA Rehabilitation
   Research and Development Traumatic Brain Injury Center of Excellence
   [B9254-C]; Cooperative Studies Program, Department of Veterans Affairs;
   National Institute of Mental Health award [5T32MH019836-18]
FX This work was supported by Merit Review Award Number I01 CX-001276-01
   from the United States (U.S.) Department of Veterans Affairs Clinical
   Sciences R&D (CSRD) Service and by a Presidential Early Career Award for
   Scientists and Engineers (PECASE 2013A) to EJW, as administered by U.S.
   Department of Veterans Affairs Office of Research and Development.
   Funding for this work is also supported by NIA R0350204413 to EJW, NIMH
   grant R21MH102834 to MWM and the Translational Research Center for TBI
   and Stress Disorders (TRACTS), a VA Rehabilitation Research and
   Development Traumatic Brain Injury Center of Excellence (B9254-C), and
   the Cooperative Studies Program, Department of Veterans Affairs. FGM's
   contribution to this work was supported by National Institute of Mental
   Health award #5T32MH019836-18.
CR Aiello AE, 2016, PSYCHONEUROENDOCRINO, V67, P133, DOI 10.1016/j.psyneuen.2016.01.024
   [Anonymous], 1995, CLIN ADM PTSD SCALE
   Aryee MJ, 2014, BIOINFORMATICS, V30, P1363, DOI 10.1093/bioinformatics/btu049
   Baker DJ, 2008, NAT CELL BIOL, V10, P825, DOI 10.1038/ncb1744
   Barfield RT, 2014, GENET EPIDEMIOL, V38, P231, DOI 10.1002/gepi.21789
   Baylis D, 2013, AGE, V35, P963, DOI 10.1007/s11357-012-9396-8
   Berent-Maoz B, 2012, BLOOD, V119, P5715, DOI 10.1182/blood-2011-12-400002
   Breitling LP, 2016, CLIN EPIGENETICS, V8, DOI 10.1186/s13148-016-0186-5
   CHAN JM, 1994, DIABETES CARE, V17, P961, DOI 10.2337/diacare.17.9.961
   Chang CC, 2015, GIGASCIENCE, V4, DOI 10.1186/s13742-015-0047-8
   Chen BH, 2016, AGING-US, V8, P1844, DOI 10.18632/aging.101020
   Chen HN, 2011, NATURE, V478, P349, DOI 10.1038/nature10502
   Chen YA, 2013, EPIGENETICS-US, V8, P203, DOI 10.4161/epi.23470
   Christiansen L, 2016, AGING CELL, V15, P149, DOI 10.1111/acel.12421
   Epel ES, 2009, HORM-INT J ENDOCRINO, V8, P7, DOI 10.14310/horm.2002.1217
   FERGUSON FG, 1995, J GERONTOL A-BIOL, V50, pB378, DOI 10.1093/gerona/50A.6.B378
   Fortin JP, 2017, BIOINFORMATICS, V33, P558, DOI 10.1093/bioinformatics/btw691
   Fülöp T, 2016, REV INVEST CLIN, V68, P84
   Gardner JP, 2005, CIRCULATION, V111, P2171, DOI 10.1161/01.CIR.0000163550.70487.0B
   Grant CD, 2017, GEROSCIENCE, V39, P475, DOI 10.1007/s11357-017-0001-z
   Hadad N, 2018, NEUROBIOL AGING, V67, P53, DOI 10.1016/j.neurobiolaging.2018.03.009
   Hahn O, 2017, GENOME BIOL, V18, DOI 10.1186/s13059-017-1187-1
   Hannum G, 2013, MOL CELL, V49, P359, DOI 10.1016/j.molcel.2012.10.016
   Holbrook JD, 2017, EPIGENOMICS-UK, V9, P1143, DOI 10.2217/epi-2017-0032
   Horvath S, 2018, NAT REV GENET, V19, P371, DOI 10.1038/s41576-018-0004-3
   Horvath S, 2013, GENOME BIOL, V14, DOI 10.1186/gb-2013-14-10-r115
   Houseman EA, 2012, BMC BIOINFORMATICS, V13, DOI 10.1186/1471-2105-13-86
   Irvin MR, 2018, CLIN EPIGENETICS, V10, DOI 10.1186/s13148-018-0481-4
   Jaffe AE, 2014, GENOME BIOL, V15, DOI 10.1186/gb-2014-15-2-r31
   Johnson WE, 2007, BIOSTATISTICS, V8, P118, DOI 10.1093/biostatistics/kxj037
   Levine ME, 2015, AGING-US, V7, P1198, DOI 10.18632/aging.100864
   Logue MW, 2013, MOL PSYCHIATR, V18, P937, DOI 10.1038/mp.2012.113
   Logue MW, 2017, EPIGENOMICS-UK, V9, P1363, DOI 10.2217/epi-2017-0078
   Lowe D, 2016, ONCOTARGET, V7, P8524, DOI 10.18632/oncotarget.7383
   Maegawa S, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00607-3
   Marioni RE, 2015, GENOME BIOL, V16, DOI 10.1186/s13059-015-0584-6
   McEwen BS, 2017, METABOLISM, V69, pS21, DOI 10.1016/j.metabol.2017.01.018
   McGlinchey RE, 2017, INT J METH PSYCH RES, V26, DOI 10.1002/mpr.1556
   Miller MW, 2018, BRAIN BEHAV IMMUN, V67, P194, DOI 10.1016/j.bbi.2017.08.022
   Muthn L. K., 1998, MPLUS USERS GUIDE
   Nevalainen T, 2017, CLIN EPIGENETICS, V9, DOI 10.1186/s13148-016-0301-7
   O'Donovan A, 2015, BIOL PSYCHIAT, V77, P365, DOI 10.1016/j.biopsych.2014.06.015
   Pawelec G, 2006, EXP GERONTOL, V41, P1239, DOI 10.1016/j.exger.2006.09.005
   Perna L, 2016, CLIN EPIGENETICS, V8, DOI 10.1186/s13148-016-0228-z
   Pidsley R, 2013, BMC GENOMICS, V14, DOI 10.1186/1471-2164-14-293
   Quach A, 2017, AGING-US, V9, P419, DOI 10.18632/aging.101168
   Ratanatharathorn A, 2017, AM J MED GENET B, V174, P619, DOI 10.1002/ajmg.b.32568
   Singh T, 2011, AGEING RES REV, V10, P319, DOI 10.1016/j.arr.2010.11.002
   Tian Y, 2017, BIOINFORMATICS, V33, P3982, DOI 10.1093/bioinformatics/btx513
   Wikby A, 2005, J GERONTOL A-BIOL, V60, P556, DOI 10.1093/gerona/60.5.556
   Wolf EJ, 2016, PSYCHOL MED, V46, P2215, DOI 10.1017/S0033291716000817
   Wolf EJ, 2019, PSYCHOL MED, V49, P791, DOI 10.1017/S0033291718001411
   Wolf EJ, 2018, PSYCHONEUROENDOCRINO, V92, P123, DOI 10.1016/j.psyneuen.2017.12.007
   Wolf EJ, 2018, PSYCHOSOM MED, V80, P42, DOI 10.1097/PSY.0000000000000506
   Wolf EJ, 2017, CURR PSYCHIAT REP, V19, DOI 10.1007/s11920-017-0823-5
   Wolf EJ, 2016, PSYCHIAT ANN, V46, P527, DOI 10.3928/00485713-20160729-01
   Wolf EJ, 2016, BIOL PSYCHIAT, V80, P363, DOI 10.1016/j.biopsych.2015.11.023
   Wolf EJ, 2016, PSYCHONEUROENDOCRINO, V63, P155, DOI 10.1016/j.psyneuen.2015.09.020
   Zheng YN, 2016, EBIOMEDICINE, V5, P68, DOI 10.1016/j.ebiom.2016.02.008
NR 59
TC 22
Z9 23
U1 0
U2 8
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD JUN 15
PY 2019
VL 11
IS 11
BP 3487
EP 3504
DI 10.18632/aging.101992
PG 18
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cell Biology; Geriatrics & Gerontology
GA ID6ON
UT WOS:000471798500009
PM 31173577
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kornicka, K
   Szlapka-Kosarzewska, J
   Smieszek, A
   Marycz, K
AF Kornicka, Katarzyna
   Szlapka-Kosarzewska, Jolanta
   Smieszek, Agnieszka
   Marycz, Krzysztof
TI 5-Azacytydine and resveratrol reverse senescence and ageing of adipose
   stem cells via modulation of mitochondrial dynamics and autophagy
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Article
DE adipose-derived mesenchymal stem cells; autophagy; metabolic syndrome;
   mitochondria; mitophagy; stem cells
ID ENDOPLASMIC-RETICULUM STRESS; OXIDATIVE STRESS; INSULIN SENSITIVITY;
   METABOLIC SYNDROME; GENE-EXPRESSION; DNA METHYLATION; DIFFERENTIATION;
   OSTEOGENESIS; CYTOKINE; PROTECTS
AB Obesity and endocrine disorders have become prevalent issues in the field of both human and veterinary medicine. Equine metabolic syndrome is a complex disorder involving alternation in metabolism and chronic systemic inflammation. It has been shown that unfavourable microenvironment of inflamed adipose tissue negatively affects adipose stem cell population (ASC) residing within, markedly limiting their therapeutic potential. ASCs(EMS) are characterized by increased senescence apoptosis, excessive accumulation of reactive oxygen species (ROS), mitochondria deterioration and "autophagic flux." The aim of the present study was to evaluate whether treatment of ASCs(EMS) with a combination of 5-azacytydine (AZA) and resveratrol (RES) would reverse aged phenotype of these cells. For this reason, we performed the following analyzes: molecular biology (RT-PCR), microscopic (immunofluorescence, TEM) and flow cytometry (JC-1, ROS, Ki67). We evaluated the mitochondrial status, dynamics and clearance as well as autophagic pathways. Furthermore, we investigated epigenetic alternations in treated cells by measuring the expression of TET genes and analysis of DNA methylation status. We have demonstrated that AZA/RES treatment of ASCs(EMS) is able to rejuvenate these cells by modulating mitochondrial dynamics, in particular by promoting mitochondrial fusion over fission. After AZA/RES treatment, ASCs(EMS) were characterized by increased proliferation rate, decreased apoptosis and senescence and lower ROS accumulation. Our findings offer a novel approach and potential targets for the beneficial effects of AZA/RES in ameliorating stem cell dysfunctions.
C1 [Kornicka, Katarzyna; Szlapka-Kosarzewska, Jolanta; Smieszek, Agnieszka; Marycz, Krzysztof] Univ Environm & Life Sci Wroclaw, Fac Biol & Anim Sci, Dept Expt Biol, Wroclaw, Poland.
   [Marycz, Krzysztof] Justus Liebig Univ, Equine Clin, Fac Vet Med, Equine Surg, Giessen, Germany.
C3 Wroclaw University of Environmental & Life Sciences; Justus Liebig
   University Giessen
RP Kornicka, K (corresponding author), Univ Environm & Life Sci Wroclaw, Fac Biol & Anim Sci, Dept Expt Biol, Wroclaw, Poland.
EM katarzyna.kornicka@upwr.edu.pl
RI Smieszek, Agnieszka/A-4887-2017
OI Smieszek, Agnieszka/0000-0002-7314-9821
FU Narodowe Centrum Nauki [2016/21/B/NZ7/01111]
FX Narodowe Centrum Nauki, Grant/Award Number: 2016/21/B/NZ7/01111
CR Armour SM, 2009, AGING-US, V1, P515, DOI 10.18632/aging.100056
   Baur JA, 2006, NATURE, V444, P337, DOI 10.1038/nature05354
   Bhullar KS, 2015, BBA-MOL BASIS DIS, V1852, P1209, DOI 10.1016/j.bbadis.2015.01.012
   Borst SE, 2004, ENDOCRINE, V23, P177, DOI 10.1385/ENDO:23:2-3:177
   Burns TA, 2010, J VET INTERN MED, V24, P932, DOI 10.1111/j.1939-1676.2010.0551.x
   CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1006/abio.1987.9999
   Fang B, 2007, TRANSPL P, V39, P3358, DOI 10.1016/j.transproceed.2007.08.103
   Flamment M, 2012, TRENDS ENDOCRIN MET, V23, P381, DOI 10.1016/j.tem.2012.06.003
   Gaballah HH, 2016, CHEM-BIOL INTERACT, V251, P10, DOI 10.1016/j.cbi.2016.03.023
   Giovannelli L, 2011, J GERONTOL A-BIOL, V66, P9, DOI 10.1093/gerona/glq161
   Gonzalez-Rey E, 2010, ANN RHEUM DIS, V69, P241, DOI 10.1136/ard.2008.101881
   Gonzalez-Rey E, 2009, GUT, V58, P929, DOI 10.1136/gut.2008.168534
   Graham RM, 2016, EXP MOL MED, V48, DOI 10.1038/emm.2015.116
   Gülçin I, 2010, INNOV FOOD SCI EMERG, V11, P210, DOI 10.1016/j.ifset.2009.07.002
   Guo L, 2017, STEM CELLS INT, V2017, DOI 10.1155/2017/1651325
   Ho TT, 2017, NATURE, V543, P205, DOI 10.1038/nature21388
   Huang YP, 2011, CELL CYCLE, V10, P3938, DOI 10.4161/cc.10.22.18107
   Ido Y, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0115341
   Kilic Eren M, 2015, PLOS ONE, V10
   Kornicka K, 2017, RSC ADV, V7, P24070, DOI 10.1039/c7ra02334k
   Kornicka K, 2018, STEM CELL REV REP, V14, P337, DOI 10.1007/s12015-018-9809-x
   Kornicka K, 2017, J CELL MOL MED, V21, P387, DOI 10.1111/jcmm.12972
   Kornicka K, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/309169
   Lagouge M, 2006, CELL, V127, P1109, DOI 10.1016/j.cell.2006.11.013
   Latorre E, 2017, BMC CELL BIOL, V18, DOI 10.1186/s12860-017-0147-7
   Lee WYW, 2017, J ORTHOP TRANSL, V9, P76, DOI 10.1016/j.jot.2017.03.005
   Lei M, 2008, ACTA PHARMACOL SIN, V29, P1350, DOI 10.1111/j.1745-7254.2008.00880.x
   Liu K, 2014, AM J CLIN NUTR, V99, P1510, DOI 10.3945/ajcn.113.082024
   Lu B, 2018, MOL MED REP, V17, P5021, DOI 10.3892/mmr.2018.8492
   Maredziak M, 2015, STEM CELLS INT, V2015, DOI 10.1155/2015/379093
   Maredziak M, 2015, IN VITRO CELL DEV-AN, V51, P230, DOI 10.1007/s11626-014-9828-0
   Marycz K, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19010165
   Marycz K, 2018, RES VET SCI, V118, P115, DOI 10.1016/j.rvsc.2018.01.015
   Marycz K, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/3718468
   Marycz K, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/4710326
   Marycz K, 2016, J CELL MOL MED, V20, P2384, DOI 10.1111/jcmm.12932
   Marycz K, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/651097
   Marycz K, 2014, J NANOMATER, V2014, DOI 10.1155/2014/350579
   Michalak I, 2011, MICROCHIM ACTA, V172, P65, DOI 10.1007/s00604-010-0468-0
   Moore LD, 2013, NEUROPSYCHOPHARMACOL, V38, P23, DOI 10.1038/npp.2012.112
   Morgan RA, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0163815
   Owens SD, 2016, STEM CELLS INT, V2016, DOI 10.1155/2016/5830103
   Ozcan L, 2012, ANNU REV MED, V63, P317, DOI 10.1146/annurev-med-043010-144749
   Paduano F, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18102140
   Pandey KB, 2009, APPL PHYSIOL NUTR ME, V34, P1093, DOI 10.1139/H09-115
   Park JW, 2007, ONCOL REP, V18, P1269
   Pezzanite LM, 2015, STEM CELL RES THER, V6, DOI 10.1186/s13287-015-0053-x
   Pileggi A, 2012, DIABETES, V61, P1355, DOI 10.2337/db12-0355
   Pinarli FA, 2013, PEDIATR HEMAT ONCOL, V30, P226, DOI 10.3109/08880018.2012.762962
   Riordan NH, 2009, J TRANSL MED, V7, DOI 10.1186/1479-5876-7-29
   Rui YF, 2015, SCI REP-UK, V5, DOI 10.1038/srep11056
   Rusin M, 2009, MECH AGEING DEV, V130, P528, DOI 10.1016/j.mad.2009.06.005
   Salemi S, 2011, CELL RES, V22
   Seeliger C, 2013, CELL TRANSPLANT, V22, P119, DOI 10.3727/096368912X638946
   Svajger U, 2012, INT REV IMMUNOL, V31, P202, DOI 10.3109/08830185.2012.665108
   Thatcher CD, 2012, J VET INTERN MED, V26, P1413, DOI 10.1111/j.1939-1676.2012.00995.x
   Treiber K, 2009, VET IMMUNOL IMMUNOP, V129, P216, DOI 10.1016/j.vetimm.2008.11.004
   Tseng PC, 2011, J BONE MINER RES, V26, P2552, DOI 10.1002/jbmr.460
   Ungvari Z, 2011, EXERC SPORT SCI REV, V39, P128, DOI 10.1097/JES.0b013e3182141f80
   Vick MM, 2008, AM J VET RES, V69, P130, DOI 10.2460/ajvr.69.1.130
   Woodward AD, 2013, J EQUINE VET SCI, V33, P460, DOI 10.1016/j.jevs.2012.08.007
   Yan XY, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0090846
   Yen GC, 2003, FREE RADICAL RES, V37, P509, DOI 10.1080/1071576031000083099
   Zang L, 2017, DIABETOL METAB SYNDR, V9, DOI 10.1186/s13098-017-0233-1
NR 64
TC 64
Z9 72
U1 0
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD JAN
PY 2019
VL 23
IS 1
BP 237
EP 259
DI 10.1111/jcmm.13914
PG 23
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA HF7MI
UT WOS:000454423300021
PM 30370650
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Morita, Y
   Ohta, M
   Inoue, T
   Honda, T
   Konno, Y
   Eguchi, Y
   Yamato, H
AF Morita, Yusaku
   Ohta, Masanori
   Inoue, Tomohiro
   Honda, Toru
   Konno, Yoshimasa
   Eguchi, Yasumasa
   Yamato, Hiroshi
TI Sense of coherence is significantly associated with both metabolic
   syndrome and lifestyle in Japanese computer software office workers
SO INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH
LA English
DT Article
DE Metabolic syndrome; Lifestyle; Sense of coherence; Job stressor;
   Atherosclerotic risk factors
ID BODY-MASS INDEX; CORONARY-HEART-DISEASE; MYOCARDIAL-INFARCTION;
   ANTONOVSKYS SENSE; JOB STRESS; HEALTH; MORTALITY; RISK; ENVIRONMENT;
   SMOKING
AB Sense of coherence (SOC) is an individual characteristic related to a positive life orientation, leading to effective coping. Little is known about the relationship between SOC and metabolic syndrome (MetS). This cross-sectional study aimed at testing the hypothesis that workers with a strong SOC have fewer atherosclerotic risk factors, including MetS, and healthier lifestyle behaviors.
   One hundred and sixty-seven computer software workers aged 20-64 years underwent a periodical health examination including assessment of body mass index, waist circumference, blood pressure, blood lipid levels, fasting blood sugar (FBS) levels and lifestyle behaviors (walking duration, smoking status, nutrition, alcohol consumption, and sleep duration). During this period, the participants also completed a 29-item questionnaire of SOC and the Brief Job Stress Questionnaire to assess job stressors such as job strain and workplace social support.
   Our results showed that the participants with a stronger SOC were likely to walk for at least 1 h a day, to eat slowly or at a moderate speed, and to sleep for at least 6 h. Compared with the participants with the weakest SOC, those with the strongest SOC had a significantly lower odds ratio (OR) for being overweight (OR = 0.31; 95% confidence interval (CI): 0.11-0.81), and having higher FBS levels (OR = 0.11; 95% CI: 0.02-0.54), dyslipidemia (OR = 0.29; 95% CI: 0.09-0.84), and MetS (OR = 0.12; 95% CI: 0.02-0.63), even after adjusting for age, gender and job stressors.
   High SOC is associated with a healthy lifestyle and fewer atherosclerotic risk factors, including MetS.
C1 [Morita, Yusaku; Ohta, Masanori; Inoue, Tomohiro; Honda, Toru; Konno, Yoshimasa; Eguchi, Yasumasa; Yamato, Hiroshi] Univ Occupat & Environm Hlth, Inst Ind Ecol Sci, Dept Hlth Dev, Kitakyushu, Fukuoka 8078555, Japan.
C3 University of Occupational & Environmental Health - Japan
RP Morita, Y (corresponding author), Univ Occupat & Environm Hlth, Inst Ind Ecol Sci, Dept Hlth Dev, Yahatanishi Ku, 1-1 Iseigaoka, Kitakyushu, Fukuoka 8078555, Japan.
EM morita@med.uoeh-u.ac.jp
RI Ohta, M./AAO-6885-2020; Morita, Yusaku/AAZ-8698-2021
OI Morita, Yusaku/0000-0002-5828-3483; Ohta, Masanori/0000-0001-9642-514X
CR Agardh EE, 2003, DIABETES CARE, V26, P719, DOI 10.2337/diacare.26.3.719
   Albertsen K, 2001, WORK STRESS, V15, P241, DOI 10.1080/02678370110066562
   [Anonymous], 2005, J Jpn Soc Intern
   Antonovsky A., 1987, J NERV MENT DIS, V177, P439
   Brummett BH, 2006, J RES PERS, V40, P222, DOI 10.1016/j.jrp.2004.12.002
   Cederlund RI, 2010, BMC MUSCULOSKEL DIS, V11, DOI 10.1186/1471-2474-11-286
   Cohen SK, 1995, MEASUREING STRESS GU
   Eriksson M, 2005, J EPIDEMIOL COMMUN H, V59, P460, DOI 10.1136/jech.2003.018085
   Eriksson M, 2006, J EPIDEMIOL COMMUN H, V60, P376, DOI 10.1136/jech.2005.041616
   Grundy SM, 2000, ENDOCRINE, V13, P155, DOI 10.1385/ENDO:13:2:155
   Höge T, 2004, J OCCUP HEALTH PSYCH, V9, P195, DOI 10.1037/1076-8998.9.3.195
   Ilanne-Parikka P, 2008, DIABETES CARE, V31, P805, DOI 10.2337/dc07-1117
   Japan Industrial Safety and Health Association, 2014, GUID STRESS CHECK
   JOHNSON JV, 1988, AM J PUBLIC HEALTH, V78, P1336, DOI 10.2105/AJPH.78.10.1336
   Karasek R.A., 1998, PsycTESTS Dataset, DOI DOI 10.1037/T03609-000
   Kato M, 2000, STUDY PREVENTION WOR, P1
   Kawada T, 2011, WORK, V40, P393, DOI 10.3233/WOR-2011-1251
   Knutsson A, 1999, OCCUP ENVIRON MED, V56, P46, DOI 10.1136/oem.56.1.46
   Kouvonen AM, 2008, BMC PUBLIC HEALTH, V8, DOI 10.1186/1471-2458-8-46
   Kuuppelomäki M, 2003, INT J NURS STUD, V40, P383, DOI 10.1016/S0020-7489(02)00103-7
   Lin YS, 2005, ANN EPIDEMIOL, V15, P590, DOI 10.1016/j.annepidem.2004.10.010
   Lindfors P, 2005, INT J BEHAV MED, V12, P98, DOI 10.1207/s15327558ijbm1202_7
   Marshall NS, 2008, SLEEP MED REV, V12, P289, DOI 10.1016/j.smrv.2008.03.001
   Nakamura H, 2003, J OCCUP HEALTH, V45, P278, DOI 10.1539/joh.45.278
   Nakamura T, 2001, JPN CIRC J, V65, P11, DOI 10.1253/jcj.65.11
   Niaura R, 2000, PSYCHOSOM MED, V62, P7, DOI 10.1097/00006842-200001000-00002
   Noda H, 2005, J AM COLL CARDIOL, V46, P1761, DOI 10.1016/j.jacc.2005.07.038
   Ozasa K, 2007, ASIAN PAC J CANCER P, V8, P89
   Peter R, 2002, J EPIDEMIOL COMMUN H, V56, P294, DOI 10.1136/jech.56.4.294
   Poppius E, 1999, SOC SCI MED, V49, P109, DOI 10.1016/S0277-9536(99)00105-7
   Sagara Takiko, 2009, Environmental Health and Preventive Medicine, V14, P319, DOI 10.1007/s12199-009-0100-2
   Saito A, 2012, APPETITE, V59, P252, DOI 10.1016/j.appet.2012.05.009
   Shimomitsu T.., 2000, The Ministry of Labor sponsored grant for the prevention of work-related illness: The 1999 report
   Surtees P, 2003, AM J EPIDEMIOL, V158, P1202, DOI 10.1093/aje/kwg272
   Svartvik L, 2000, SCAND J PRIM HEALTH, V18, P177
   Teraoka S, 2013, TOHOKU J EXP MED, V229, P5, DOI 10.1620/tjem.229.5
   [The Ministry of Health Law [Internet], 2011, SUMM VIT STAT
   Wainwright NWJ, 2008, J EPIDEMIOL COMMUN H, V62, P829, DOI 10.1136/jech.2007.066464
   Wainwright NWJ, 2007, J EPIDEMIOL COMMUN H, V61, DOI 10.1136/jech.2006.056275
   Yamazaki Y, 1999, QUALITY NURSING, V5, P824
NR 40
TC 14
Z9 14
U1 1
U2 10
PU NOFER INST OCCUPATIONAL MEDICINE, POLAND
PI LODZ
PA SW TERESY 8, LODZ, 91-348, POLAND
SN 1232-1087
EI 1896-494X
J9 INT J OCCUP MED ENV
JI Int. J. Occup. Med. Environ. Health
PD DEC
PY 2014
VL 27
IS 6
BP 967
EP 979
DI 10.2478/s13382-014-0322-4
PG 13
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA AY6ND
UT WOS:000347682000008
PM 25556337
OA gold
DA 2025-06-11
ER

PT J
AU Akase, T
   Nagase, T
   Huang, LJ
   Ibuki, A
   Minematsu, T
   Nakagami, G
   Ohta, Y
   Shimada, T
   Aburada, M
   Sugama, J
   Sanada, H
AF Akase, Tomoko
   Nagase, Takashi
   Huang, Lijuan
   Ibuki, Ai
   Minematsu, Takeo
   Nakagami, Gojiro
   Ohta, Yasunori
   Shimada, Tsutomu
   Aburada, Masaki
   Sugama, Junko
   Sanada, Hiromi
TI Aging-Like Skin Changes Induced by Ultraviolet Irradiation in an Animal
   Model of Metabolic Syndrome
SO BIOLOGICAL RESEARCH FOR NURSING
LA English
DT Article
DE aging; skin; ultraviolet irradiation; metabolic syndrome
ID MOUSE; DAMAGE; RESISTANCE; COLLAGEN
AB Both physiological skin aging and pathologic photo-aging caused by ultraviolet (UV) irradiation are mediated by latent inflammation and oxidative stress. Although numerous animal skin-aging models have used UV irradiation, most require massive doses or long-term irradiation. To establish a more refined skin-aging model, we focused on an animal model of metabolic syndrome (MS) because MS involves damage to various organs via oxidative stress or inflammation, similar to the changes associated with aging. We hypothesized that MS skin might exhibit more aging-like changes after milder, shorter-term UV irradiation than would normal animal skin under similar conditions, thus providing a useful model for skin aging. The authors therefore examined the skin from Tsumura Suzuki obese diabetic (TSOD) mice (MS model) and control Tsumura Suzuki non-obese (TSNO) mice before and after UV irradiation. Skin from TSOD mice had a thinner epidermis and dermis, a thicker fatty layer, reduced density and convolution of the fragmented collagen fibers, and upregulated expression of tumor necrosis factor (TNF)-alpha, a dual marker for inflammation and aging, compared to the skin from TSNO mice. UV irradiation affected TSOD skin more severely than TSNO skin, resulting in various changes resembling those in aged human skin, including damage to the dermis and subcutaneous fatty tissue, infiltration of inflammatory cells, and further upregulation of TNF-alpha expression. These results suggest that UV-irradiated TSOD mice may provide a new model of skin aging and imply that skin from humans with MS is more susceptible to UV- or aging-related damage than normal human skin.
C1 [Sanada, Hiromi] Univ Tokyo, Grad Sch Med, Dept Gerontol Nursing Wound Care Management, Div Hlth Sci & Nursing,Bunkyo Ku, Tokyo 1130033, Japan.
   [Minematsu, Takeo; Sugama, Junko] Univ Tokyo, Grad Sch Med, Dept Adv Skin Care Miss Paris, Tokyo 1130033, Japan.
   [Ohta, Yasunori] Toranomon Gen Hosp, Dept Pathol, Tokyo, Japan.
   [Shimada, Tsutomu; Aburada, Masaki] Musashino Univ, Pharmaceut Sci Res Inst, Tokyo, Japan.
C3 University of Tokyo; University of Tokyo; Toranomon Hospital
RP Sanada, H (corresponding author), Univ Tokyo, Grad Sch Med, Dept Gerontol Nursing Wound Care Management, Div Hlth Sci & Nursing,Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan.
EM hsanada-tky@umin.ac.jp
RI SUGAMA, Junko/J-8410-2015; Nakagami, Gojiro/V-9093-2019
OI Nakagami, Gojiro/0000-0002-9650-2464; Minematsu,
   Takeo/0000-0001-5859-7290
FU MEXT (Ministry of Education Culture, Sports, Science and Technology)
   [21659494]; Grants-in-Aid for Scientific Research [21659494] Funding
   Source: KAKEN
FX The authors disclosed receipt of the following financial support for the
   research and/or authorship of this article: This work was supported by a
   grant-in-aid for scientific research from MEXT (Ministry of Education
   Culture, Sports, Science and Technology; No. 21659494).
CR [Anonymous], 1996, GUID CAR US LAB AN
   Baumann L, 2007, J PATHOL, V211, P241, DOI 10.1002/path.2098
   Callaghan T. M., 2008, International Journal of Cosmetic Science, V30, P313, DOI 10.1111/j.1468-2494.2008.00454.x
   Cohen AD, 2008, DERMATOLOGY, V216, P152, DOI 10.1159/000111512
   Craven NM, 1997, BRIT J DERMATOL, V137, P344
   El-Domyati M, 2002, EXP DERMATOL, V11, P398, DOI 10.1034/j.1600-0625.2002.110502.x
   ENSER M, 1984, DIABETOLOGIA, V27, P44
   Ezure T, 2010, EXP DERMATOL, V19, P878, DOI 10.1111/j.1600-0625.2009.00970.x
   Goto M, 2008, BIOSCI TRENDS, V2, P218
   Haratake A, 1997, J INVEST DERMATOL, V108, P769, DOI 10.1111/1523-1747.ep12292163
   Iizuka S, 2005, EXP ANIM TOKYO, V54, P71, DOI 10.1538/expanim.54.71
   Inomata S, 2003, J INVEST DERMATOL, V120, P128, DOI 10.1046/j.1523-1747.2003.12021.x
   Khaskhely NM, 2002, CLIN DIAGN LAB IMMUN, V9, P677, DOI 10.1128/CDLI.9.3.677-686.2002
   Kim YG, 2009, EUR J PHARMACOL, V602, P148, DOI 10.1016/j.ejphar.2008.11.021
   Kobayashi S, 2006, YAKUGAKU ZASSHI, V126, P677, DOI 10.1248/yakushi.126.677
   Kuroo M, 1997, NATURE, V390, P45, DOI 10.1038/36285
   LAVKER RM, 1979, J INVEST DERMATOL, V73, P59, DOI 10.1111/1523-1747.ep12532763
   Manya H, 2010, YAKUGAKU ZASSHI, V130, P3, DOI 10.1248/yakushi.130.3
   Nagase M, 2006, J AM SOC NEPHROL, V17, P3438, DOI 10.1681/ASN.2006080944
   Nagase T, 2009, STUD MECHANOBIOL TIS, V1, P301
   Oberyszyn TM, 1998, MOL CARCINOGEN, V22, P16
   Paolisso G, 1998, AM J PHYSIOL-ENDOC M, V275, pE294, DOI 10.1152/ajpendo.1998.275.2.E294
   Paz ML, 2008, CYTOKINE, V44, P70, DOI 10.1016/j.cyto.2008.06.012
   Seo MY, 2009, J BIOSCI BIOENG, V107, P266, DOI 10.1016/j.jbiosc.2008.11.016
   Smalls LK, 2006, SKIN RES TECHNOL, V12, P43, DOI 10.1111/j.0909-725X.2006.00135.x
   Suzuki W, 1999, EXP ANIM TOKYO, V48, P181, DOI 10.1538/expanim.48.181
   SUZUKI W, 2002, DIABETES FRONTIER, V13, P106
   SUZUKI W, 1999, LAB ANIMAL SCI TECHN, V11, P99
   SUZUKI W, 2005, LAB ANIMAL SCI TECHN, V17, P112
   SUZUKI W, 1998, DIABETES FRONT, V9, P485
   Takahashi A, 2006, METABOLISM, V55, P1664, DOI 10.1016/j.metabol.2006.08.007
   TAKEDA T, 1994, ARCH GERONTOL GERIAT, V19, P185, DOI 10.1016/0167-4943(94)90039-6
   Yasuoka S, 2005, PHOTOCHEM PHOTOBIOL, V81, P908, DOI 10.1562/2004-09-02-RA-300R2.1
NR 33
TC 23
Z9 24
U1 0
U2 17
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1099-8004
EI 1552-4175
J9 BIOL RES NURS
JI Biol. Res. Nurs.
PD APR
PY 2012
VL 14
IS 2
BP 180
EP 187
DI 10.1177/1099800411401013
PG 8
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nursing
GA 930HL
UT WOS:000303128200009
PM 21444332
DA 2025-06-11
ER

PT J
AU Park, SK
   Schwartz, J
   Weisskopf, M
   Sparrow, D
   Vokonas, PS
   Wright, RO
   Coull, B
   Nie, HL
   Hu, H
AF Park, Sung Kyun
   Schwartz, Joel
   Weisskopf, Marc
   Sparrow, David
   Vokonas, Pantel S.
   Wright, Robert O.
   Coull, Brent
   Nie, Huiling
   Hu, Howard
TI Low-level lead exposure, metabolic syndrome, and heart rate variability:
   The VA Normative Aging Study
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE autonomic nervous system; bone lead; heart rate variability;
   hypertension; metabolic syndrome
ID CARDIOVASCULAR-DISEASE; BLOOD-PRESSURE; LIPID-PEROXIDATION;
   ATHEROSCLEROSIS RISK; AUTONOMIC FUNCTION; OXIDATIVE STRESS;
   RENAL-FUNCTION; NITRIC-OXIDE; BONE LEAD; HYPERTENSION
AB BACKGROUND: Altered heart rate variability (HRV), a marker of poor cardiac autonomic function, has been associated with sudden cardiac death and heart failure.
   OBJECTIVE: We examined the association of low-level lead exposure measured in bone by K-X-ray fluorescence with alterations in HRV, and whether metabolic syndrome (MetS) or its individual components modify those associations.
   METHODS: HRV measures [power in high-frequency (HFnorm) and low-frequency (LFnorm) in normalized units, and LF/HF] were taken among 413 elderly men from the Normative Aging Study. MetS was defined as subjects having three or more of the following criteria: abdominal obesity, hypertriglyceridemia, low high-density lipoprotein, high blood pressure, and high fasting glucose.
   RESULTS: Of the subjects, 32% were identified as having MetS. Inverse but nonstatistically significant associations of both tibia and patella lead levels with HFnorm and nonstatistically significant positive relations with LFnorm and LF/HF were found in the entire cohort. There was a graded, statistically significant reduction in HFnorm and increases in LFnorm and LF/HF in association with an increase in patella lead as the number of metabolic abnormalities increased. We also observed that higher patella lead was consistently associated with lower HFnorm, and higher LFnorm and LF/HF among subjects with MetS or its individual components. No statistically significant interaction between MetS and tibia lead was observed.
   CONCLUSION: The results suggest that elderly men with MetS were more susceptible to autonomic dysfunction in association with chronic lead exposure as measured in patella. The modification by MetS is consistent with a role for oxidative stress in lead toxicity on the cardiovascular system.
C1 Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.
   Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med,Channing Lab, Boston, MA 02115 USA.
   Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA.
   Boston Univ, Sch Med, VA Normat Aging, Vet Affairs Boston Healthcare Syst, Boston, MA 02215 USA.
   Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health; Harvard
   University; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Harvard Medical School; Harvard University; Harvard T.H. Chan
   School of Public Health; Boston University; Harvard University; Harvard
   University Medical Affiliates; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); VA Boston Healthcare System;
   Boston University
RP Park, SK (corresponding author), Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, SPH 2,M6240,109 S Observ St, Ann Arbor, MI 48109 USA.
EM sungkyun@umich.edu
RI Schwartz, Joel/JRY-6780-2023; Hu, Howard/AAV-5360-2021
OI Hu, Howard/0000-0002-3676-2707; Park, Sung Kyun/0000-0001-9981-6250
FU NIEHS NIH HHS [R01 ES010798, ES05257, T32 ES07069, ES10798, P42-ES05947,
   P30 ES000002, P42 ES005947, T32 ES007069, ES00002, R01 ES005257] Funding
   Source: Medline
CR AHNVE S, 1982, CIRCULATION, V65, P435, DOI 10.1161/01.CIR.65.3.435
   BELL B, 1972, AGING HUM DEVELOP, V3, P5, DOI 10.2190/GGVP-XLB5-PC3N-EF0G
   Böckelmann I, 2002, J OCCUP ENVIRON MED, V44, P59
   Burger D E, 1990, Basic Life Sci, V55, P287
   Camm AJ, 1996, CIRCULATION, V93, P1043
   Cheng YW, 1998, AM J CARDIOL, V82, P594, DOI 10.1016/S0002-9149(98)00402-0
   Chowdhary S, 2002, CLIN SCI, V102, P397, DOI 10.1042/CS20010230
   Ding YX, 2000, AM J HYPERTENS, V13, P552, DOI 10.1016/S0895-7061(99)00226-5
   Dursun N, 2005, BIOL TRACE ELEM RES, V104, P141, DOI 10.1385/BTER:104:2:141
   Eilers PHC, 1996, STAT SCI, V11, P89, DOI 10.1214/ss/1038425655
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   Fracasso ME, 2002, MUTAT RES-GEN TOX EN, V515, P159, DOI 10.1016/S1383-5718(02)00012-8
   GENNART JP, 1992, INT ARCH OCC ENV HEA, V64, P49, DOI 10.1007/BF00625951
   Gerritsen J, 2001, DIABETES CARE, V24, P1793, DOI 10.2337/diacare.24.10.1793
   Gurer H, 2000, FREE RADICAL BIO MED, V29, P927, DOI 10.1016/S0891-5849(00)00413-5
   Hemingway H, 2005, CIRCULATION, V111, P3071, DOI 10.1161/CIRCULATIONAHA.104.497347
   Hu H, 1998, ENVIRON HEALTH PERSP, V106, P1, DOI 10.2307/3433626
   Hu H, 1996, JAMA-J AM MED ASSOC, V275, P1171, DOI 10.1001/jama.275.15.1171
   Jhun HJ, 2005, INT ARCH OCC ENV HEA, V78, P243, DOI 10.1007/s00420-004-0591-5
   Kim R, 1997, AM J EPIDEMIOL, V146, P586, DOI 10.1093/oxfordjournals.aje.a009318
   KOBER TE, 1976, NATURE, V262, P704, DOI 10.1038/262704a0
   Korrick SA, 1999, AM J PUBLIC HEALTH, V89, P330, DOI 10.2105/AJPH.89.3.330
   Kristal-Boneh E, 2000, J CARDIOVASC RISK, V7, P141
   Liao DP, 1998, DIABETES CARE, V21, P2116, DOI 10.2337/diacare.21.12.2116
   Lustberg M, 2002, ARCH INTERN MED, V162, P2443, DOI 10.1001/archinte.162.21.2443
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Moller DE, 2005, ANNU REV MED, V56, P45, DOI 10.1146/annurev.med.56.082103.104751
   MURATA K, 1993, ENVIRON RES, V61, P323, DOI 10.1006/enrs.1993.1077
   MURATA K, 1991, AM J IND MED, V20, P663, DOI 10.1002/ajim.4700200509
   Nash D, 2003, JAMA-J AM MED ASSOC, V289, P1523, DOI 10.1001/jama.289.12.1523
   Öktem F, 2004, ARCH TOXICOL, V78, P681, DOI 10.1007/s00204-004-0597-5
   Park SK, 2005, ENVIRON HEALTH PERSP, V113, P304, DOI 10.1289/ehp.7447
   Pikkujämsä SM, 1998, AM J HYPERTENS, V11, P523, DOI 10.1016/S0895-7061(98)00035-1
   ROSNER B, 1983, TECHNOMETRICS, V25, P165, DOI 10.2307/1268549
   SANDHIR R, 1994, MOL CELL BIOCHEM, V131, P25, DOI 10.1007/BF01075721
   SANDHIR R, 1995, BIOL TRACE ELEM RES, V48, P91, DOI 10.1007/BF02789081
   Schroeder EB, 2003, HYPERTENSION, V42, P1106, DOI 10.1161/01.HYP.0000100444.71069.73
   SCHWARTZ J, 1991, ENVIRON HEALTH PERSP, V91, P71, DOI 10.2307/3430985
   Singh JP, 1998, HYPERTENSION, V32, P293, DOI 10.1161/01.HYP.32.2.293
   Tapanainen JM, 2002, AM J CARDIOL, V90, P347, DOI 10.1016/S0002-9149(02)02488-8
   TERUYA K, 1991, INT ARCH OCC ENV HEA, V62, P549, DOI 10.1007/BF00381107
   The R Foundation for Statistical Computing, 2006, R PROJ STAT COMP
   Tsaih SW, 2004, ENVIRON HEALTH PERSP, V112, P1178, DOI 10.1289/ehp.7024
   Tsuji H, 1996, CIRCULATION, V94, P2850, DOI 10.1161/01.CIR.94.11.2850
   Vaziri ND, 2002, J HYPERTENS, V20, pS15
   Wood SN, 2000, J ROY STAT SOC B, V62, P413, DOI 10.1111/1467-9868.00240
   Ye XB, 1999, J TOXICOL ENV HEAL A, V57, P161, DOI 10.1080/009841099157737
NR 48
TC 67
Z9 75
U1 0
U2 11
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
   RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD NOV
PY 2006
VL 114
IS 11
BP 1718
EP 1724
DI 10.1289/ehp.8992
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA 102OS
UT WOS:000241822300033
PM 17107858
OA Green Submitted, Green Published, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Peixoto-Silva, N
   Conceiçao, EPS
   Carvalho, JC
   Lima, NS
   Nogueira-Neto, JF
   de Oliveira, E
   Moura, EG
   Lisboa, PC
AF Peixoto-Silva, Nayara
   Conceicao, Ellen P. S.
   Carvalho, Janaine C.
   Lima, Natalia S.
   Nogueira-Neto, Jose Firmino
   de Oliveira, Elaine
   Moura, Egberto G.
   Lisboa, Patricia C.
TI Does bromocriptine play a role in decreasing oxidative stress for early
   weaned programmed obesity?
SO LIFE SCIENCES
LA English
DT Article
DE Early weaning; Bromocriptine; Obesity; Liver disease; Antioxidant system
ID MATERNAL PROLACTIN INHIBITION; LACTATION PROGRAMS; METABOLIC SYNDROME;
   LEPTIN RESISTANCE; RATS; MODEL; DYSFUNCTION; STEATOSIS; SIRTUINS; FAT
AB Aims: Studies have demonstrated that early weaning can promote metabolic syndrome during adulthood and that obesity increases oxidative stress. Thus, we aimed to evaluate redox status in a pharmacological early weaning rodent model programmed for metabolic syndrome at adulthood.
   Main methods: Lactating dams were randomly assigned into 2 groups: the early weaning group (BRO), which was treated intraperitoneally with bromocriptine (1 mg/day) to inhibit prolactin secretion for the last 3 days of lactation, and the control group (C), which received the BRO diluent for the same time period. The offspring were killed at 90 (PN90) and 180 (PN180) days after birth.
   Key findings: Early weaning induced greater visceral adiposity and dyslipidemia. At PN90, the BRO offspring showed glucose intolerance with normoinsulinemia and increased plasma and liver superoxide dismutase, and liver glutathione peroxidase activities, which reduced the liver malondialdehyde but not the increased plasma malondialdehyde levels. However, the BRO offspring showed insulin resistance at PN180 and increased plasma glutathione peroxidase, liver superoxide dismutase, and catalase activities. These changes reduced the plasma and liver malondialdehyde levels, which aided in hepatocyte architecture preservation. Additionally, we observed that sirtuin 1 was overexpressed in the BRO group at PN90, but the increased expression was not maintained through PN180, which suggests unfavorable metabolic conditions in the older offspring.
   Significance: Despite the observed obesity and glucose homeostasis dysfunction, our data suggest that the early weaning programming induced by bromocriptine can improve the offspring's redox status and may prevent liver damage during adulthood. (C) 2013 Elsevier Inc All rights reserved.
C1 [Peixoto-Silva, Nayara; Conceicao, Ellen P. S.; Carvalho, Janaine C.; Lima, Natalia S.; de Oliveira, Elaine; Moura, Egberto G.; Lisboa, Patricia C.] Roberto Alcantara Gomes Biol Inst, Dept Physiol Sci, Rio De Janeiro, Brazil.
   [Nogueira-Neto, Jose Firmino] Univ Estado Rio De Janeiro, Sch Med, Lab Lipids, Rio De Janeiro, Brazil.
C3 Universidade do Estado do Rio de Janeiro
RP Lisboa, PC (corresponding author), Univ Estado Rio de Janeiro, Dept Ciencias Fisiol, Inst Biol, 5 Andar,Av 28 Setembro 87, BR-20551030 Rio De Janeiro, RJ, Brazil.
EM pclisboa@uerj.br
RI Moura, Egberto/ABA-6188-2021; Peixoto-Silva, Nayara/P-5072-2015; Lima,
   Natalia Sarmanho/KMA-7618-2024; Lisboa, Patricia/H-8336-2015; Moura,
   Egberto/H-1270-2012
OI Lisboa, Patricia/0000-0002-2477-4364; Conceicao Furber,
   Ellen/0000-0003-0370-1032; Moura, Egberto/0000-0002-1159-7549
FU National Council for Scientific and Technological Development (Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq);
   Coordination for the Enhancement of Higher Education Personnel
   (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -CAPES);
   State of Rio de Janeiro Carlos Chagas Filho Research Foundation
   (Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de
   Janeiro -FAPERJ)
FX All authors are grateful to Miss Monica Moura and Mr. Ulisses Risso
   Siqueira for technical assistance. This research was supported by the
   National Council for Scientific and Technological Development (Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq), the
   Coordination for the Enhancement of Higher Education Personnel
   (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -CAPES) and
   the State of Rio de Janeiro Carlos Chagas Filho Research Foundation
   (Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de
   Janeiro -FAPERJ).
CR Bonomo IT, 2008, J ENDOCRINOL, V198, P331, DOI 10.1677/JOE-07-0505
   Bonomo IT, 2007, J ENDOCRINOL, V192, P339, DOI 10.1677/joe.1.06952
   Bonomo IT, 2005, HORM METAB RES, V37, P220, DOI 10.1055/s-2005-861381
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Casimiro-Lopes G, 2012, HORM METAB RES, V44, P123, DOI 10.1055/s-0031-1299711
   Colak Y., 2011, MED SCI MONITOR, V17, P5
   Conceiçao EPS, 2013, EUR J NUTR, V52, P1393, DOI 10.1007/s00394-012-0448-8
   Conceiçao EPS, 2013, J NUTR BIOCHEM, V24, P81, DOI 10.1016/j.jnutbio.2012.02.010
   Davis LM, 2006, J HEPATOL, V45, P439, DOI 10.1016/j.jhep.2006.03.019
   Davis LM, 2009, NEUROENDOCRINOLOGY, V89, P152, DOI 10.1159/000170586
   de Moura EG, 2009, J PHYSIOL-LONDON, V587, P4919, DOI 10.1113/jphysiol.2009.176289
   Drummond GB, 2009, J PHYSIOL-LONDON, V587, P713, DOI 10.1113/jphysiol.2008.167387
   Dunmore SJ, 2013, J ENDOCRINOL, V216, pT37, DOI 10.1530/JOE-12-0278
   Franco JG, 2013, J NUTR BIOCHEM, V24, P960, DOI 10.1016/j.jnutbio.2012.06.019
   Guarente L, 2006, NATURE, V444, P868, DOI 10.1038/nature05486
   Kaeberlein M, 2005, J BIOL CHEM, V280, P17038, DOI 10.1074/jbc.M500655200
   Kar S, 2012, FREE RADICAL RES, V46, P1496, DOI 10.3109/10715762.2012.731052
   Kassab A, 2012, BIOCHIMIE, V94, P1837, DOI 10.1016/j.biochi.2012.01.020
   Kline AE, 2004, J NEUROTRAUM, V21, P1712, DOI 10.1089/neu.2004.21.1712
   Lima NS, 2013, HORM METAB RES, V45, P22, DOI 10.1055/s-0032-1323703
   Lima ND, 2011, BRIT J NUTR, V105, P1405, DOI 10.1017/S0007114510005064
   Oddy Wendy H, 2012, Breastfeed Rev, V20, P7
   Oliveira LD, 2011, BEHAV PROCESS, V86, P75, DOI 10.1016/j.beproc.2010.09.005
   Peixoto-Silva N, 2011, BRIT J NUTR, V106, P1364, DOI 10.1017/S0007114511001735
   Pfluger PT, 2008, P NATL ACAD SCI USA, V105, P9793, DOI 10.1073/pnas.0802917105
   Popovic M, 2008, MOLECULES, V13, P2249, DOI 10.3390/molecules13092249
   Savini I, 2013, INT J MOL SCI, V14, P10497, DOI 10.3390/ijms140510497
   Sloan S, 2008, CHILD CARE HLTH DEV, V34, P59, DOI 10.1111/j.1365-2214.2007.00771.x
   YOSHIKAWA T, 1994, J NEUROCHEM, V62, P1034
NR 29
TC 13
Z9 13
U1 0
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JAN 24
PY 2014
VL 95
IS 1
BP 14
EP 21
DI 10.1016/j.lfs.2013.12.013
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 297MS
UT WOS:000330260200003
PM 24361363
DA 2025-06-11
ER

PT J
AU Singhal, J
   Nagaprashantha, L
   Vatsyayan, R
   Awasthi, S
   Singhal, SS
AF Singhal, Jyotsana
   Nagaprashantha, Lokesh
   Vatsyayan, Rit
   Awasthi, Sanjay
   Singhal, Sharad S.
TI RLIP76, a Glutathione-Conjugate Transporter, Plays a Major Role in the
   Pathogenesis of Metabolic Syndrome
SO PLOS ONE
LA English
DT Article
ID ATP-DEPENDENT TRANSPORT; OXIDATIVE STRESS; FRUCTOSE 1,6-DIPHOSPHATASE;
   INSULIN-SECRETION; SKELETAL-MUSCLE; PROTEIN; LIVER; ENDOCYTOSIS;
   INHIBITION; EXPRESSION
AB Purpose: Characteristic hypoglycemia, hypotriglyceridemia, hypocholesterolemia, lower body mass, and fat as well as pronounced insulin-sensitivity of RLIP76(-/-) mice suggested to us the possibility that elevation of RLIP76 in response to stress could itself elicit metabolic syndrome (MSy). Indeed, if it were required for MSy, drugs used to treat MSy should have no effect on RLIP76(-/-) mice.
   Research Design and Methods: Blood glucose (BG) and lipid measurements were performed in RLIP76(+/+) and RLIP76(-/-) mice, using Ascensia Elite Glucometer (R) for glucose and ID Labs kits for cholesterol and triglycerides assays. The ultimate effectors of gluconeogenesis are the three enzymes: PEPCK, F-1,6-BPase, and G6Pase, and their expression is regulated by PPAR gamma and AMPK. The activity of these enzymes was tested by protocols standardized by us. Expressions of RLIP76, PPAR alpha, PPAR gamma, HMGCR, pJNK, pAkt, and AMPK were performed by Western-blot and tissue staining.
   Results: The concomitant activation of AMPK and PPAR gamma by inhibiting transport activity of RLIP76, despite inhibited activity of key glucocorticoid-regulated hepatic gluconeogenic enzymes like PEPCK, G6Pase and F-1,6-BP in RLIP76(-/-) mice, is a salient finding of our studies. The decrease in RLIP76 protein expression by rosiglitazone and metformin is associated with an up-regulation of PPAR gamma and AMPK.
   Conclusions/Significance: All four drugs, rosiglitazone, metformin, gemfibrozil and atorvastatin failed to affect glucose and lipid metabolism in RLIP76(-/-) mice. Studies confirmed a model in which RLIP76 plays a central role in the pathogenesis of MSy and RLIP76 loss causes profound and global alterations of MSy signaling functions. RLIP76 is a novel target for single-molecule therapeutics for metabolic syndrome.
C1 [Singhal, Jyotsana; Nagaprashantha, Lokesh; Awasthi, Sanjay; Singhal, Sharad S.] Natl Med Ctr, Beckman Res Inst, Dept Diabet & Metab Dis Res, Duarte, CA USA.
   [Vatsyayan, Rit] Univ N Texas, Hlth Sci Ctr, Dept Mol Biol & Immunol, Ft Worth, TX USA.
C3 City of Hope; Beckman Research Institute of City of Hope; University of
   North Texas System; University of North Texas Health Science Center
RP Singhal, J (corresponding author), Natl Med Ctr, Beckman Res Inst, Dept Diabet & Metab Dis Res, Duarte, CA USA.
EM ssinghal@coh.org
RI Nagaprashantha, Lokesh/A-6661-2012; Awasthi, Sanjay/R-4904-2019;
   Singhal, Ashutosh/H-6725-2019
OI Dalasanur Nagaprashantha, Lokesh PG/0000-0001-7041-1970; Singhal,
   Jyotsana/0009-0004-0119-9370; Awasthi, Sanjay/0000-0002-5214-5717
FU National Institutes of Health [CA 77495]; Cancer Research Foundation of
   North Texas
FX This work was supported in part by National Institutes of Health Grant
   CA 77495 and Cancer Research Foundation of North Texas. The funders had
   no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
CR Anisimov VN, 2010, AGING-US, V2, P945, DOI 10.18632/aging.100245
   Anisimov VN, 2010, AGING-US, V2, P760, DOI 10.18632/aging.100230
   Annaloro C, 2008, BONE MARROW TRANSPL, V41, P797, DOI 10.1038/sj.bmt.1705972
   Awasthi S, 2000, BIOCHEMISTRY-US, V39, P9327, DOI 10.1021/bi992964c
   Awasthi S, 2005, CANCER RES, V65, P6022, DOI 10.1158/0008-5472.CAN-05-0968
   Awasthi S, 2003, INT J CANCER, V106, P635, DOI 10.1002/ijc.11260
   Awasthi S, 2010, DIABETES, V59, P714, DOI 10.2337/db09-0911
   Belgardt BF, 2010, AGING-US, V2, P621, DOI 10.18632/aging.100192
   Belgardt BF, 2010, P NATL ACAD SCI USA, V107, P6028, DOI 10.1073/pnas.1001796107
   Cefalu WT, 2008, DIAB MET SYND CLIN R, V2, P208, DOI 10.1016/j.dsx.2008.04.001
   Diehl AM, 2004, GUT, V53, P923, DOI 10.1136/gut.2003.037309
   Ding QR, 2009, CELL RES, V19, P317, DOI 10.1038/cr.2008.299
   Evans JL, 2003, DIABETES, V52, P1, DOI 10.2337/diabetes.52.1.1
   Evans JL, 2005, ANTIOXID REDOX SIGN, V7, P1040, DOI 10.1089/ars.2005.7.1040
   FONSECA MA, 2005, CLIN CORNERSTONE, V7, P61
   GIEROW P, 1980, ANAL BIOCHEM, V101, P305, DOI 10.1016/0003-2697(80)90191-8
   Ginsberg Henry N, 2009, J Cardiometab Syndr, V4, P113, DOI 10.1111/j.1559-4572.2008.00044.x
   Han R, 2007, DIABETOLOGIA, V50, P1960, DOI 10.1007/s00125-007-0752-7
   Hayes JD, 1995, CRIT REV BIOCHEM MOL, V30, P445, DOI 10.3109/10409239509083491
   Ikeda M, 1998, J BIOL CHEM, V273, P814, DOI 10.1074/jbc.273.2.814
   Jakoby W B, 1978, Adv Enzymol Relat Areas Mol Biol, V46, P383
   Jones TH, 2010, J DIABETES, V2, P146, DOI 10.1111/j.1753-0407.2010.00085.x
   JULLIENFLORES V, 1995, J BIOL CHEM, V270, P22473, DOI 10.1074/jbc.270.38.22473
   Krishnaswami Ashok, 2010, Perm J, V14, P64
   Kurucz I, 2002, DIABETES, V51, P1102, DOI 10.2337/diabetes.51.4.1102
   Lagouge M, 2006, CELL, V127, P1109, DOI 10.1016/j.cell.2006.11.013
   Maechler P, 1999, J BIOL CHEM, V274, P27905, DOI 10.1074/jbc.274.39.27905
   Mäuser W, 2007, EUR J PHARMACOL, V564, P37, DOI 10.1016/j.ejphar.2007.02.024
   Nagaprashantha LD, 2011, CARCINOGENESIS, V32, P568, DOI 10.1093/carcin/bgr021
   OPIE LH, 1967, BIOCHEM J, V104, P353, DOI 10.1042/bj1040353
   Pessler D, 2001, DIABETOLOGIA, V44, P2156, DOI 10.1007/s001250100024
   Pollak M, 2010, CANCER PREV RES, V3, P1060, DOI 10.1158/1940-6207.CAPR-10-0175
   Puglianiello Antonella, 2006, Review of Diabetic Studies, V3, P54, DOI 10.1900/RDS.2006.3.54
   Robertson RP, 2004, DIABETES, V53, pS119, DOI 10.2337/diabetes.53.2007.S119
   Rossé C, 2003, J BIOL CHEM, V278, P30597, DOI 10.1074/jbc.M302191200
   Sakai K, 2003, BIOCHEM BIOPH RES CO, V300, P216, DOI 10.1016/S0006-291X(02)02832-2
   Sanguino E, 2004, BIOCHEM PHARMACOL, V67, P157, DOI 10.1016/j.bcp.2003.08.034
   Sharma R, 2004, INT J CANCER, V112, P934, DOI 10.1002/ijc.20516
   Singhal J, 2008, INT J RADIAT ONCOL, V72, P553, DOI 10.1016/j.ijrobp.2008.06.1497
   Singhal SS, 2008, J BIOL CHEM, V283, P19714, DOI 10.1074/jbc.M708703200
   Singhal SS, 2007, CANCER RES, V67, P4382, DOI 10.1158/0008-5472.CAN-06-4124
   Singhal SS, 2011, MOL CANCER THER, V10, P16, DOI 10.1158/1535-7163.MCT-10-0699
   Singhal SS, 2009, CANCER LETT, V283, P152, DOI 10.1016/j.canlet.2009.03.033
   Singhal SS, 2009, CANCER RES, V69, P4244, DOI 10.1158/0008-5472.CAN-08-3521
   Singhal SS, 2009, BIOCHEM PHARMACOL, V77, P761, DOI 10.1016/j.bcp.2008.10.006
   Singhal SS, 2009, INT J ONCOL, V34, P191, DOI 10.3892/ijo_00000141
   Singhal SS, 2006, CANCER RES, V66, P2354, DOI 10.1158/0008-5472.CAN-05-3534
   TAKETA K, 1965, J BIOL CHEM, V240, P651
   Talior I, 2003, AM J PHYSIOL-ENDOC M, V285, pE295, DOI 10.1152/ajpendo.00044.2003
   Tenenbaum A, 2003, CARDIOVASC DIABETOL, V2, DOI 10.1186/1475-2840-2-4
   Tiedge M, 1997, DIABETES, V46, P1733, DOI 10.2337/diabetes.46.11.1733
   Tomkin GH, 2009, CURR OPIN LIPIDOL, V20, P10, DOI 10.1097/MOL.0b013e32831ac56c
   Vatsyayan R, 2010, BIOCHEM PHARMACOL, V79, P1699, DOI 10.1016/j.bcp.2010.01.016
   Vetterli L, 2011, AGING-US, V3, P444, DOI 10.18632/aging.100304
NR 54
TC 41
Z9 44
U1 0
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 13
PY 2011
VL 6
IS 9
AR e24688
DI 10.1371/journal.pone.0024688
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 825ZV
UT WOS:000295321800049
PM 21931813
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Kosinski, C
   Rossel, JB
   Gross, J
   Helbling, C
   Quansah, DY
   Collet, TH
   Puder, JJ
AF Kosinski, Christophe
   Rossel, Jean-Benoit
   Gross, Justine
   Helbling, Celine
   Quansah, Dan Yedu
   Collet, Tinh-Hai
   Puder, Jardena J.
TI Adverse metabolic outcomes in the early and late postpartum after
   gestational diabetes are broader than glucose control
SO BMJ OPEN DIABETES RESEARCH & CARE
LA English
DT Article; Proceedings Paper
CT International DIP Symposium on Diabetes, Hypertension, Metabolic
   Syndrome and Preganancy
CY MAY 29-JUN 01, 2019
CL Florence, ITALY
ID LONG-TERM RISK; WEIGHT CHANGE; WOMEN; HISTORY; DEPRESSION; PREDICTORS;
   PREGNANCY; MELLITUS; GDM
AB Introduction: Gestational diabetes mellitus is associated with an increased cardiovascular risk. To better target preventive measures, we performed an in-depth characterization of cardiometabolic risk factors in a cohort of women with gestational diabetes in the early (6-8 weeks) and late (1 year) postpartum.
   Research design and methods: Prospective cohort of 622 women followed in a university gestational diabetes clinic between 2011 and 2017. 162 patients who attended the late postpartum visit were analyzed in a nested long-term cohort starting in 2015. Metabolic syndrome (MetS) was based on the International Diabetes Federation definition, and then having at least two additional criteria of the MetS (blood pressure, triglycerides, high-density lipoprotein (HDL) cholesterol, plasma glucose above or below the International Diabetes Federation cut-offs).
   Results: Compared with prepregnancy, weight retention was 4.8 +/- 6.0 kg in the early postpartum, and the prevalence of obesity, pre-diabetes, MetS-body mass index (BMI) and MetS-waist circumference (WC) were 28.8%, 28.9%, 10.3% and 23.8%, respectively. Compared with the early postpartum, weight did not change and waist circumference decreased by 2.6 +/- 0.6 cm in the late postpartum. However, the prevalence of obesity, pre-diabetes, MetS-WC and MetS-BMI increased (relative increase: 11% for obesity, 82% for pre-diabetes, 50% for MetS-WC, 100% for MetS-BMI; all p <= 0.001).
   Predictors for obesity were the use of glucose-lowering treatment during pregnancy and the prepregnancy BMI. Predictors for pre-diabetes were the early postpartum fasting glucose value and family history of diabetes. Finally, systolic blood pressure in pregnancy and in the early postpartum, the 2-hour post oral glucose tolerance test glycemia and the HDL-cholesterol predicted the development of MetS (all p<0.05).
   Conclusions: The prevalence of metabolic complications increased in the late postpartum, mainly due to an increase in fasting glucose and obesity, although weight did not change. We identified predictors of late postpartum obesity, pre-diabetes and MetS that could lead to high-risk identification and targeted preventions.
C1 [Kosinski, Christophe; Gross, Justine; Helbling, Celine; Collet, Tinh-Hai] Lausanne Univ Hosp, Serv Endocrinol Diabet & Metab, Lausanne, Switzerland.
   [Kosinski, Christophe; Rossel, Jean-Benoit; Gross, Justine; Helbling, Celine; Quansah, Dan Yedu; Collet, Tinh-Hai; Puder, Jardena J.] Univ Lausanne, Lausanne, Switzerland.
   [Rossel, Jean-Benoit; Gross, Justine; Quansah, Dan Yedu; Puder, Jardena J.] Lausanne Univ Hosp, Serv Obstet, Dept Woman Mother Child, Lausanne, Switzerland.
   [Collet, Tinh-Hai] Geneva Univ Hosp, Serv Endocrinol Diabetol Nutr & Therapeut Educ, Geneva, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; University of Lausanne; Centre Hospitalier
   Universitaire Vaudois (CHUV); University of Geneva
RP Kosinski, C (corresponding author), Lausanne Univ Hosp, Serv Endocrinol Diabet & Metab, Lausanne, Switzerland.; Kosinski, C (corresponding author), Univ Lausanne, Lausanne, Switzerland.
EM christophe.kosinski@chuv.ch
RI Collet, Tinh-Hai/I-4462-2019; Kosinski, Christophe/ABB-6319-2021;
   Quansah, Dan/B-8499-2018
OI Rossel, Jean-Benoit/0000-0001-5803-3233; Quansah,
   Dan/0000-0002-3091-9400; Kosinski, Christophe/0000-0002-7544-498X;
   Collet, Tinh-Hai/0000-0002-3243-1222; Puder, Jardena/0000-0002-0460-7614
FU Swiss National Science Foundation [SNF 32003B-176119]; Leenaards
   Foundation; Vontobel Foundation; Swiss Society of Endocrinology and
   Diabetes; Swiss Multiple Sclerosis Society; Novo Nordisk
FX This study is a pilot of a project grant by the Swiss National Science
   Foundation (SNF 32003B--176119). The cohort database received an
   unrestricted educational grant from Novo Nordisk. T--HC research is
   supported by grants from the Swiss National Science Foundation, the
   Leenaards Foundation, the Vontobel Foundation, the Swiss Society of
   Endocrinology and Diabetes, and the Swiss Multiple Sclerosis Society.
CR Ajala O, 2015, DIABETES RES CLIN PR, V110, P309, DOI 10.1016/j.diabres.2015.10.004
   Akinci B, 2011, GYNECOL ENDOCRINOL, V27, P361, DOI 10.3109/09513590.2010.492885
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Amer Diabet Assoc, 2021, DIABETES CARE, V44, pS200, DOI 10.2337/dc21-S014
   Amer Diabet Assoc, 2021, DIABETES CARE, V44, pS15, DOI 10.2337/dc21-S002
   Amorim AR, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005627.pub2
   Antoniou MC, 2020, J CLIN MED, V9, DOI 10.3390/jcm9082409
   Antoniou MC, 2019, BMC PREGNANCY CHILDB, V19, DOI 10.1186/s12884-019-2610-2
   Bao W, 2015, DIABETOLOGIA, V58, P1212, DOI 10.1007/s00125-015-3537-4
   Barquiel B, 2014, DIABETES METAB, V40, P204, DOI 10.1016/j.diabet.2013.12.011
   Bellamy L, 2009, LANCET, V373, P1773, DOI 10.1016/S0140-6736(09)60731-5
   Casey BM, 2020, AM J PERINAT, V37, P475, DOI 10.1055/s-0039-1681058
   CATALANO PM, 1991, AM J OBSTET GYNECOL, V165, P914, DOI 10.1016/0002-9378(91)90438-W
   Cho NH, 2018, DIABETES RES CLIN PR, V138, P271, DOI 10.1016/j.diabres.2018.02.023
   COUSTAN DR, 1993, AM J OBSTET GYNECOL, V168, P1139, DOI 10.1016/0002-9378(93)90358-P
   Deputy NP, 2018, MMWR-MORBID MORTAL W, V67, P1201, DOI 10.15585/mmwr.mm6743a2
   Eckel RH, 2010, LANCET, V375, P181, DOI 10.1016/S0140-6736(09)61794-3
   Gilbert L, 2021, PSYCHONEUROENDOCRINO, V124, DOI 10.1016/j.psyneuen.2020.105095
   Goyal A, 2019, DIABETOLOGIA, V62, P1357, DOI 10.1007/s00125-019-4903-4
   Gunderson EP, 2021, CIRCULATION, V143, P974, DOI 10.1161/CIRCULATIONAHA.120.047320
   Hakkarainen H, 2018, BMC PREGNANCY CHILDB, V18, DOI 10.1186/s12884-018-1958-z
   Hakkarainen H, 2016, GYNECOL ENDOCRINOL, V32, P920, DOI 10.1080/09513590.2016.1198764
   Henkel V, 2003, BRIT MED J, V326, P200, DOI 10.1136/bmj.326.7382.200
   Huvinen E, 2018, ACTA DIABETOL, V55, P493, DOI 10.1007/s00592-018-1118-y
   Jeppsson JO, 2002, CLIN CHEM LAB MED, V40, P78, DOI 10.1515/CCLM.2002.016
   Kasher-Meron M, 2017, DIABETES-METAB RES, V33, DOI 10.1002/dmrr.2909
   Kramer CK, 2019, DIABETOLOGIA, V62, P905, DOI 10.1007/s00125-019-4840-2
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Li W, 2015, DIABETIC MED, V32, P1492, DOI 10.1111/dme.12790
   Löbner K, 2006, DIABETES, V55, P792, DOI 10.2337/diabetes.55.03.06.db05-0746
   Matthey S, 2006, ARCH WOMEN MENT HLTH, V9, P309, DOI 10.1007/s00737-006-0152-x
   Metzger BE, 2010, DIABETES CARE, V33, P676, DOI 10.2337/dc09-1848
   Noctor E, 2015, WORLD J DIABETES, V6, P234, DOI 10.4239/wjd.v6.i2.234
   Nouhjah S, 2018, DIABETES METAB SYND, V12, P317, DOI 10.1016/j.dsx.2017.12.027
   Quansah DY, 2021, DIABETOL METAB SYNDR, V13, DOI 10.1186/s13098-021-00650-7
   Quansah DY, 2020, DIABETES RES CLIN PR, V165, DOI 10.1016/j.diabres.2020.108238
   Quansah DY, 2021, J HEALTH PSYCHOL, V26, P1168, DOI 10.1177/1359105319869814
   Quansah DY, 2019, EAT BEHAV, V34, DOI 10.1016/j.eatbeh.2019.101304
   Rayanagoudar G, 2016, DIABETOLOGIA, V59, P1403, DOI 10.1007/s00125-016-3927-2
   Rosselet Patricia, 2017, Rev Med Suisse, V13, P1305
   Rüetschi JR, 2016, BJOG-INT J OBSTET GY, V123, P2219, DOI 10.1111/1471-0528.13857
   Shen Y, 2019, DIABETES RES CLIN PR, V150, P219, DOI 10.1016/j.diabres.2019.03.030
   Skajaa GO, 2020, BMJ OPEN DIAB RES CA, V8, DOI 10.1136/bmjdrc-2020-001728
   Tobias DK, 2017, JAMA INTERN MED, V177, P1735, DOI 10.1001/jamainternmed.2017.2790
   Topp CW, 2015, PSYCHOTHER PSYCHOSOM, V84, DOI 10.1159/000376585
   Waters TP, 2020, DIABETOLOGIA, V63, P385, DOI 10.1007/s00125-019-05051-0
   Wood Jamie R, 2012, J Diabetes Sci Technol, V6, P380
   Xu YH, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0087863
   Yefet E, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0881-6
   Ziegler AG, 2012, DIABETES, V61, P3167, DOI 10.2337/db12-0393
NR 50
TC 4
Z9 4
U1 0
U2 5
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
EI 2052-4897
J9 BMJ OPEN DIAB RES CA
JI BMJ Open Diab. Res. Care
PD NOV
PY 2021
VL 9
IS 2
AR e002382
DI 10.1136/bmjdrc-2021-002382
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism
GA WU4HB
UT WOS:000716506600001
PM 34750153
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dongre, P
   Majumdar, A
AF Dongre, Prashant
   Majumdar, Anuradha
TI Network pharmacology analysis of Chandraprabha Vati: A new
   hope for the treatment of Metabolic Syndrome
SO JOURNAL OF AYURVEDA AND INTEGRATIVE MEDICINE
LA English
DT Article
DE Network pharmacology; Metabolic syndrome (MetS); Chandraprabha vati
   (CPV); Binding DB; Cytoscape; GO enrichment
ID ANTIDIABETIC ACTIVITY; CYPERUS-ROTUNDUS; DRUG DISCOVERY; INFLAMMATION;
   HYPERLIPIDEMIA; CROSSTALK; RECEPTORS; EXTRACT; INSULIN; OBESITY
AB Background: Drug research is increasingly using Network Pharmacology (NP) to tackle complex conditions like Metabolic Syndrome (MetS), which is characterized by obesity, hyperglycemia, and dyslipidemia. Single-action drugs are inadequate to treat MetS, which is marked by a range of complications including glucose intolerance, hyperlipidemia, mitochondrial dysfunction, and inflammation. Objectives: To analyze Chandraprabha vati using Network Pharmacology to assess its potential in alleviating MetSrelated complications. Material and methods: The genes related to MetS, inflammation, and the target genes of the CPV components were identified using network pharmacology tools like DisgNET and BindingDB. Followed by mapping of the CPV target genes with the genes implicated in MetS and inflammation to identify putative potential targets. Gene ontology, pathway enrichment analysis, and STRING database were employed for further exploration. Furthermore, drug-target-protein interactions network were visualized using Cytoscape 3.9.1. Results: The results showed that out of the 225 target genes of the CPV components, 33 overlapping and 19 nonoverlapping genes could be potential targets for MetS. Similarly, 14 overlapping and 7 non-overlapping genes could be potential targets for inflammation. The CPV bioactives target genes were found to be involved in lipid and insulin homeostasis via several pathways revealed by the pathway analysis. The importance of CPV in treating MetS was supported by GO enrichment data; this could be due to its potential to influence pathways linked to metabolism, ER stress, mitochondrial dysfunction, oxidative stress, and inflammation. Conclusions: These results offer a promising approach to developing treatment and repurposing CPV for complex conditions such as MetS.
C1 [Dongre, Prashant; Majumdar, Anuradha] Bombay Coll Pharm, Dept Pharmacol, Mumbai 400098, India.
RP Majumdar, A (corresponding author), Bombay Coll Pharm, Dept Pharmacol, Mumbai 400098, India.
EM anuradha.majumdar@gmail.com
CR Abbate A, 2020, CIRC RES, V126, P1260, DOI 10.1161/CIRCRESAHA.120.315937
   Agostini L, 2004, IMMUNITY, V20, P319, DOI 10.1016/S1074-7613(04)00046-9
   Aguirre GA, 2016, J TRANSL MED, V14, DOI 10.1186/s12967-015-0762-z
   Asha B., 2011, Journal of Chemical and Pharmaceutical Research, V3, P452
   Bairoch A, 2005, NUCLEIC ACIDS RES, V33, pD154, DOI 10.1093/nar/gki070
   Barros RPA, 2011, CELL METAB, V14, P289, DOI 10.1016/j.cmet.2011.08.005
   Bhalerao S, 2014, Annals of Plant Sciences, V3, P770
   Bhalwar Rajvir, 2020, Med J Armed Forces India, V76, P8, DOI 10.1016/j.mjafi.2019.12.001
   Bhandari U, 2008, INDIAN J EXP BIOL, V46, P607
   Bing C, 2015, ADIPOCYTE, V4, P149, DOI 10.4161/21623945.2014.979661
   Boumiza S, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-99577-2
   Caër C, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-02660-w
   Carrasco-Gallardo Carlos, 2012, Int J Alzheimers Dis, V2012, P674142, DOI 10.1155/2012/674142
   Castro AM., 2017, Revista Medica del Hospital General de Mexico, V80, P101, DOI [10.1016/j.hgmx.2016.06, DOI 10.1016/J.HGMX.2016.06]
   Chandran U, 2017, INNOVATIVE APPROACHES IN DRUG DISCOVERY: ETHNOPHARMACOLOGY, SYSTEMS BIOLOGY, AND HOLISTIC TARGETING, P127, DOI 10.1016/B978-0-12-801814-9.00005-2
   Chandran U, 2015, COMB CHEM HIGH T SCR, V18, P846, DOI 10.2174/1386207318666151019093606
   Chandran Uma, 2015, Proceedings of the Indian National Science Academy, V81, P561
   Chao Wen-Wan, 2010, Chin Med, V5, P17, DOI 10.1186/1749-8546-5-17
   Chao WW, 2010, J AGR FOOD CHEM, V58, P2505, DOI 10.1021/jf903629j
   Chaudhary A. K., 2011, Pharmacognosy Journal, V3, P12, DOI 10.5530/pj.2011.23.2
   Chen SD, 2011, INT J MOL SCI, V12, P7199, DOI 10.3390/ijms12107199
   Choudhary Dr Anand K, 2007, Bhaisajyaratavali of shri govinda dasgi, VI, P2592
   Clemmons DR, 2012, ENDOCRIN METAB CLIN, V41, P425, DOI 10.1016/j.ecl.2012.04.017
   Csép K, 2017, ACTA ENDOCRINOL-BUCH, V13, P161, DOI 10.4183/aeb.2017.161
   de Jong H, 2003, BIOINFORMATICS, V19, P336, DOI 10.1093/bioinformatics/btf851
   de Souza CO, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.715877
   Devasani K, 2019, Obes Med, V16, P1
   Di S, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/7043402
   Eisele PS, 2014, SEMIN IMMUNOPATHOL, V36, P27, DOI 10.1007/s00281-013-0406-4
   Furuhashi M, 2014, CLIN MED INSIGHTS-CA, V8, P23, DOI 10.4137/CMC.S17067
   Gao L, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-017-18325-7
   Government of India Ministry of Health and Family Welfare, 2003, New Delhi: department of Ayurveda, yoga and naturopathy US and H. Ayurvedic formulary of India part -1, P512
   Harun-Or-Rashid M., 2006, Pakistan Journal of Biological Sciences, V9, P2261, DOI 10.3923/pjbs.2006.2261.2266
   Hauner H, 2005, P NUTR SOC, V64, P163, DOI 10.1079/PNS2005428
   Jahan N, 2012, INT J AGRIC BIOL, V14, P989
   Jensen LJ, 2009, NUCLEIC ACIDS RES, V37, pD412, DOI 10.1093/nar/gkn760
   Ju Y, 2016, AFR HEALTH SCI, V16, P1000, DOI 10.4314/ahs.v16i4.16
   Kadlec AO, 2016, ARTERIOSCL THROM VAS, V36, P1467, DOI 10.1161/ATVBAHA.116.307123
   Kaleem M, 2005, Indian J Physiol Pharmacol, V49, P65
   Korikanthimath V. S., 1999, Journal of Plantation Crops, V27, P230
   Kralisch S, 2005, FEBS LETT, V579, P6417, DOI 10.1016/j.febslet.2005.10.033
   Kulloli R. N., 2013, Journal of Medicinal Plants Research, V7, P2043
   Kuroda M, 2005, BIOL PHARM BULL, V28, P937, DOI 10.1248/bpb.28.937
   Lee EL, 2022, DRUG SAFETY, V45, P713, DOI 10.1007/s40264-022-01189-w
   Li S, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/138460
   Li S, 2010, BMC BIOINFORMATICS, V11, DOI 10.1186/1471-2105-11-S11-S6
   Li WW, 2017, FRONT PHARMACOL, V8, P15, DOI 10.3389/fphar.2017.00074
   Liu TQ, 2007, NUCLEIC ACIDS RES, V35, pD198, DOI 10.1093/nar/gkl999
   Luo F, 2014, MOL BIOSYST, V10, P1912, DOI 10.1039/c4mb00105b
   Mali R. G., 2008, International Journal of Green Pharmacy, V2, P194
   Mukherjee PK, 2007, PHARM BIOL, V45, P651, DOI 10.1080/13880200701538724
   Murali YK, 2007, EXP CLIN ENDOCR DIAB, V115, P641, DOI 10.1055/s-2007-982500
   Nabi SA, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-37
   Naseri M, 2010, J Med Plants, V9, P57
   OGURA M, 1978, PLANTA MED, V33, P128, DOI 10.1055/s-0028-1097367
   Okoli CO, 2010, AFR J BIOTECHNOL, V9, P248
   Pandey PS, 2019, Int J Pharm Sci Rev Res, V59, P140
   Pathan M, 2015, PROTEOMICS, V15, P2597, DOI 10.1002/pmic.201400515
   Patwardhan B, 2015, INTEGRATIVE APPROACHES FOR HEALTH: BIOMEDICAL RESEARCH, AYURVEDA AND YOGA, P1
   Patwardhan B, 2014, COMB CHEM HIGH T SCR, V17, P97, DOI 10.2174/138620731702140119160627
   Piñero J, 2015, DATABASE-OXFORD, DOI 10.1093/database/bav028
   Popko K, 2010, EUR J MED RES, V15, P120
   Potdar D, 2012, FITOTERAPIA, V83, P817, DOI 10.1016/j.fitote.2012.04.012
   Prisilla David Hansi, 2012, Asian Pacific Journal of Tropical Biomedicine, V2, pS941
   Rafeeq MM, 2016, PHARMACOGENOMICS, V17, P2015, DOI 10.2217/pgs.16.30
   Rajan A, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-31560-w
   Raman Karthik, 2014, Syst Synth Biol, V8, P73, DOI 10.1007/s11693-013-9123-5
   Ranawat AK, 2017, Int J Complement Altern Med, V5, P1
   Raut N. A., 2014, Research Journal of Pharmaceutical, Biological and Chemical Sciences, V5, P137
   Raut NA, 2006, FITOTERAPIA, V77, P585, DOI 10.1016/j.fitote.2006.09.006
   Ribeiro P. R. E., 2020, Journal of Medicinal Plants Research, V14, P326, DOI 10.5897/JMPR2020.6966
   Richa Singh Richa Singh, 2012, Pharmacognosy Journal, V4, P1, DOI 10.5530/pj.2012.28.1
   Rius-Pérez S, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/1452696
   Rocha FG, 2020, J ETHNOPHARMACOL, V254, DOI 10.1016/j.jep.2020.112709
   Rouka E, 2020, MICROB PATHOGENESIS, V141, DOI 10.1016/j.micpath.2020.104000
   Ruszkowska-Ciastek B, 2014, J ZHEJIANG UNIV-SC B, V15, P575, DOI 10.1631/jzus.B1400024
   Sabu MC, 2009, INDIAN J EXP BIOL, V47, P270
   Saha S, 2012, ANC SCI LIFE, V31, P151, DOI 10.4103/0257-7941.107344
   Samad F, 2013, BLOOD, V122, P3415, DOI 10.1182/blood-2013-05-427708
   Sarup P, 2015, SCIENTIFICA, V2015, DOI 10.1155/2015/138039
   Semwal B. C., 2009, International Journal of Green Pharmacy, V3, P259, DOI 10.4103/0973-8258.56288
   Sengupta A., 2009, Mol Targets Ther Uses Spices Mod Uses Anc Med, P65, DOI 10.1142/9789812837912_0003
   Shanmugam Manoharan Shanmugam Manoharan, 2007, Journal of Biological Sciences, V7, P161
   Shannon P, 2003, GENOME RES, V13, P2498, DOI 10.1101/gr.1239303
   Sharma A., 2018, International Journal of Current Research, V10, P65758
   Sharma H, 2011, J ALTERN COMPLEM MED, V17, P491, DOI 10.1089/acm.2010.0396
   Sharma Komal Sharma Komal, 2011, International Journal of Research in Ayurveda and Pharmacy (IJRAP), V2, P383
   Sharma V, 2020, J CLIN MED, V9, DOI 10.3390/jcm9041176
   Shukla Babita, 2021, Clinical Phytoscience, V7, DOI 10.1186/s40816-021-00271-7
   Sivapalan S.R.S., 2013, Int. J. Sci. Res. Publ, V3, P2250
   Stanely P, 2000, J ETHNOPHARMACOL, V70, P9, DOI 10.1016/S0378-8741(99)00136-1
   Stark K, 2021, NAT REV CARDIOL, V18, P666, DOI 10.1038/s41569-021-00552-1
   Sumayya Saied, 2007, J Basic Appl Sci, V3, P1
   Suresh P., 1995, Sachitra Ayurved, V49, P395
   Tirgar PR, 2011, Pharmacologyonline, V2, P556
   Trivedi N. A., 2004, Indian Journal of Pharmacology, V36, P373
   Ukani M D, 1996, Anc Sci Life, V16, P166
   Varghese R, 2022, CURR RES PHYSIOL, V5, P36, DOI 10.1016/j.crphys.2021.12.004
   VERMA SK, 1988, INDIAN J MED RES, V87, P356
   Wanjari MM, 2016, J AYURVEDA INTEGR ME, V7, P144, DOI 10.1016/j.jaim.2016.08.010
   WHO Media Team G, WHO establishes the Global Centre for Traditional Medicine in India
   Wu HS, 2009, J ETHNOPHARMACOL, V123, P288, DOI 10.1016/j.jep.2009.03.004
   Xiang SY, 2019, COMPUT BIOL MED, V110, P1, DOI 10.1016/j.compbiomed.2019.05.007
   Yang RH, 2007, CIRC RES, V101, P545, DOI 10.1161/CIRCRESAHA.107.156596
   Yang YJ, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-08737-6
   Yu MX, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/5801591
   Zafar MI, 2018, DIABETOL METAB SYNDR, V10, DOI 10.1186/s13098-018-0363-0
   Zafar MI, 2017, BIOSCIENCE REP, V37, DOI 10.1042/BSR20171089
   Zhang Y, 2015, ACTA PHARMACOL SIN, V36, P71, DOI 10.1038/aps.2014.120
   Zimmermann GR, 2007, DRUG DISCOV TODAY, V12, P34, DOI 10.1016/j.drudis.2006.11.008
NR 110
TC 0
Z9 0
U1 1
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0975-9476
EI 0976-2809
J9 J AYURVEDA INTEGR ME
JI J. Ayurveda Integr. Med.
PD MAY-JUN
PY 2024
VL 15
IS 3
AR 100902
DI 10.1016/j.jaim.2024.100902
EA MAY 2024
PG 13
WC Integrative & Complementary Medicine
WE Emerging Sources Citation Index (ESCI)
SC Integrative & Complementary Medicine
GA UK5J3
UT WOS:001247962500001
PM 38821011
OA gold
DA 2025-06-11
ER

PT J
AU García-García, FJ
   Monistrol-Mula, A
   Cardellach, F
   Garrabou, G
AF Josep Garcia-Garcia, Francesc
   Monistrol-Mula, Anna
   Cardellach, Francesc
   Garrabou, Gloria
TI Nutrition, Bioenergetics, and Metabolic Syndrome
SO NUTRIENTS
LA English
DT Review
DE mitochondria; metabolic syndrome; mitochondrial dysfunction; balanced
   diet; nutrients; lifestyle
ID POLYUNSATURATED FATTY-ACIDS; IMPROVES INSULIN SENSITIVITY;
   CARDIOVASCULAR RISK-FACTORS; SKELETAL-MUSCLE CELLS; AGED GARLIC EXTRACT;
   VIRGIN OLIVE OIL; OXIDATIVE STRESS; KETOGENIC DIET; MITOCHONDRIAL
   DYSFUNCTION; BLOOD-PRESSURE
AB According to the World Health Organization (WHO), the global nutrition report shows that whilst part of the world's population starves, the other part suffers from obesity and associated complications. A balanced diet counterparts these extreme conditions with the proper proportion, composition, quantity, and presence of macronutrients, micronutrients, and bioactive compounds. However, little is known on the way these components exert any influence on our health. These nutrients aiming to feed our bodies, our tissues, and our cells, first need to reach mitochondria, where they are decomposed into CO2 and H2O to obtain energy. Mitochondria are the powerhouse of the cell and mainly responsible for nutrients metabolism, but they are also the main source of oxidative stress and cell death by apoptosis. Unappropriated nutrients may support mitochondrial to become the Trojan horse in the cell. This review aims to provide an approach to the role that some nutrients exert on mitochondria as a major contributor to high prevalent Western conditions including metabolic syndrome (MetS), a constellation of pathologic conditions which promotes type II diabetes and cardiovascular risk. Clinical and experimental data extracted from in vitro animal and cell models further demonstrated in patients, support the idea that a balanced diet, in a healthy lifestyle context, promotes proper bioenergetic and mitochondrial function, becoming the best medicine to prevent the onset and progression of MetS. Any advance in the prevention and management of these prevalent complications help to face these challenging global health problems, by ameliorating the quality of life of patients and reducing the associated sociosanitary burden.
C1 [Josep Garcia-Garcia, Francesc; Monistrol-Mula, Anna; Cardellach, Francesc; Garrabou, Gloria] Univ Barcelona, Hosp Clin Barcelona, Muscle Res & Mitochondrial Funct Lab, Internal Med Dept,Fac Med,CELLEX IDIBAPS, Barcelona 08036, Spain.
   [Josep Garcia-Garcia, Francesc; Monistrol-Mula, Anna; Cardellach, Francesc; Garrabou, Gloria] CIBERER Ctr Biomed Res Network Rare Dis, Madrid 28029, Spain.
C3 University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; CIBER -
   Centro de Investigacion Biomedica en Red; CIBERER
RP Garrabou, G (corresponding author), Univ Barcelona, Hosp Clin Barcelona, Muscle Res & Mitochondrial Funct Lab, Internal Med Dept,Fac Med,CELLEX IDIBAPS, Barcelona 08036, Spain.; Garrabou, G (corresponding author), CIBERER Ctr Biomed Res Network Rare Dis, Madrid 28029, Spain.
EM fjgarcia@ub.edu; annamoni95@gmail.com; fcardell@clinic.cat;
   garrabou@clinic.cat
RI Monistrol-Mula, Anna/GPX-5402-2022
OI Monistrol Mula, Anna/0000-0001-5879-3558; Garrabou,
   Gloria/0000-0001-8973-9933; Garcia Garcia, Francesc
   Josep/0000-0001-9021-0324; Cardellach, Francesc/0000-0003-3286-3436
FU Fondo de Investigaciones Sanitarias of the Instituto de Salud Carlos III
   (ISCIII) [PI1800498, PI1800451]; Centro de Investigacion Biomedica en
   Red de Enfermedades Raras (CIBERER), all initiatives of ISCIII; FEDER
   (`Una manera de hacer Europa'); Fundacio Privada Cellex; Suports a Grups
   de Recerca [2017 SGR 893]; CERCA programs from the Generalitat de
   Catalunya
FX The funders had no role in the study design, data collection and
   interpretation, or the decision to submit the work for publication, but
   contributed to support staff and material resources. This work was
   supported by funds from the Fondo de Investigaciones Sanitarias of the
   Instituto de Salud Carlos III (ISCIII) (grant numbers PI1800498 and
   PI1800451), the Centro de Investigacion Biomedica en Red de Enfermedades
   Raras (CIBERER), all initiatives of ISCIII and FEDER (`Una manera de
   hacer Europa'), as well as Fundacio Privada Cellex and Suports a Grups
   de Recerca (grant code 2017 SGR 893) and CERCA programs from the
   Generalitat de Catalunya.
CR Acin-Perez R, 2010, FASEB J, V24, P627, DOI 10.1096/fj.09-142281
   Agarwal S, 1998, LIPIDS, V33, P981, DOI 10.1007/s11745-998-0295-6
   Agostoni C, 2010, EFSA J, V8, DOI 10.2903/j.efsa.2010.1459
   Alehagen U, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0174880
   Allen MD, 2019, JCI INSIGHT, V4, DOI 10.1172/jci.insight.130949
   Andreasen AS, 2010, BRIT J NUTR, V104, P1831, DOI 10.1017/S0007114510002874
   [Anonymous], 2018, OXID MED CELL LONGEV, DOI DOI 10.1155/2018/4637861
   [Anonymous], 2016, NUTRIENTS, DOI DOI 10.3390/nu8030128
   [Anonymous], 2017, OXID MED CELL LONGEV
   [Anonymous], 2017, Microbiome
   [Anonymous], 2012, BRIT J NUTR, DOI DOI 10.1017/S0007114511003163
   [Anonymous], 2020, NUTRIENTS
   [Anonymous], NIH OFF DIET S
   [Anonymous], 2009, MORT BURD DIS ATTR S
   [Anonymous], 2019, INT J MOL SCI
   Aon MA, 2015, ANTIOXID REDOX SIGN, V22, P1563, DOI 10.1089/ars.2014.6123
   Area-Gomez E, 2012, EMBO J, V31, P4106, DOI 10.1038/emboj.2012.202
   Armani A, 2017, FASEB J, V31, P4240, DOI 10.1096/fj.201601125RRR
   Arola-Arnal A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025982
   Aron-Wisnewsky J, 2019, CURR DIABETES REP, V19, DOI 10.1007/s11892-019-1180-z
   Aschner P, 2010, EXPERT REV CARDIOVAS, V8, P407, DOI 10.1586/ERC.10.13
   Asgary S, 2019, REV ENDOCR METAB DIS, V20, P173, DOI 10.1007/s11154-019-09494-z
   Ashoori M, 2014, BRIT J NUTR, V111, P1985, DOI 10.1017/S0007114514000178
   Badimon L, 2019, CURR MED CHEM, V26, P3639, DOI 10.2174/0929867324666170428103206
   Bahmani F, 2016, BRIT J NUTR, V116, P1222, DOI 10.1017/S0007114516003251
   Baillie RA, 1999, PROSTAG LEUKOTR ESS, V60, P351, DOI 10.1016/S0952-3278(99)80011-8
   Bárcena C, 2018, INT REV CEL MOL BIO, V340, P35, DOI 10.1016/bs.ircmb.2018.05.002
   Barreto FM, 2014, NUTRITION, V30, P939, DOI 10.1016/j.nut.2013.12.004
   Basu A, 2010, J NUTR, V140, P1582, DOI 10.3945/jn.110.124701
   Baughman JM, 2011, NATURE, V476, P341, DOI 10.1038/nature10234
   Bell EL, 2011, MOL CELL, V42, P561, DOI 10.1016/j.molcel.2011.05.008
   Bentley-Lewis R, 2007, NAT CLIN PRACT ENDOC, V3, P696, DOI 10.1038/ncpendmet0616
   Berg AH, 2005, CIRC RES, V96, P939, DOI 10.1161/01.RES.0000163635.62927.34
   Bernatoniene J, 2018, MOLECULES, V23, DOI 10.3390/molecules23040965
   Berthold HK, 2012, J HYPERTENS, V30, P1328, DOI 10.1097/HJH.0b013e32835414df
   Bhatti JS, 2017, BBA-MOL BASIS DIS, V1863, P1066, DOI 10.1016/j.bbadis.2016.11.010
   Bigagli E, 2017, INT IMMUNOPHARMACOL, V43, P147, DOI 10.1016/j.intimp.2016.12.012
   Borujeni MJS, 2018, J CELL BIOCHEM, V119, P1257, DOI 10.1002/jcb.26271
   Bouzid MA, 2015, SPORTS MED, V45, P1245, DOI 10.1007/s40279-015-0348-1
   Brioche T, 2016, CURR PHARM DESIGN, V22, P2664, DOI 10.2174/1381612822666160219120531
   Bugiani M, 2006, BRAIN DEV-JPN, V28, P576, DOI 10.1016/j.braindev.2006.04.001
   Bullon P, 2016, EXPERIENTIA SUPPL, V107, P129, DOI 10.1007/978-3-319-43589-3_6
   Burge MR, 2001, METABOLISM, V50, P171, DOI 10.1053/meta.2001.20194
   Bussler S, 2017, HORM RES PAEDIAT, V88, P181, DOI 10.1159/000479510
   Campbell Amy P, 2017, Diabetes Spectr, V30, P76, DOI 10.2337/ds16-0084
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cantó C, 2009, NATURE, V458, P1056, DOI 10.1038/nature07813
   Cardinali DP, 2017, CELL MOL LIFE SCI, V74, P3941, DOI 10.1007/s00018-017-2611-0
   Castellano JM, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9110683
   Cena H, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020334
   Chaâbane M, 2016, BIOL TRACE ELEM RES, V169, P261, DOI 10.1007/s12011-015-0426-0
   Chassaing B, 2017, GUT, V66, P1414, DOI 10.1136/gutjnl-2016-313099
   Chen HC, 2007, CELL, V130, P548, DOI 10.1016/j.cell.2007.06.026
   Chen HC, 2010, CELL, V141, P280, DOI 10.1016/j.cell.2010.02.026
   Cheng ZY, 2013, ANTIOXID REDOX SIGN, V19, P240, DOI 10.1089/ars.2013.5255
   Choo HJ, 2006, DIABETOLOGIA, V49, P784, DOI 10.1007/s00125-006-0170-2
   Choudhary Prema Ram, 2018, Journal of Dietary Supplements, V15, P499, DOI 10.1080/19390211.2017.1358233
   Cohen HY, 2004, SCIENCE, V305, P390, DOI 10.1126/science.1099196
   Coll T, 2008, J BIOL CHEM, V283, P11107, DOI 10.1074/jbc.M708700200
   Contreras L, 2010, BBA-BIOENERGETICS, V1797, P607, DOI 10.1016/j.bbabio.2010.05.005
   Cooper SA, 2007, AM J PHYSIOL-HEART C, V293, pH2009, DOI 10.1152/ajpheart.00522.2007
   Couillard C, 2005, J CLIN ENDOCR METAB, V90, P6454, DOI 10.1210/jc.2004-2438
   Coyne T, 2005, AM J CLIN NUTR, V82, P685, DOI 10.1093/ajcn/82.3.685
   Dabke K, 2019, J CLIN INVEST, V129, P4050, DOI 10.1172/JCI129194
   Danial NN, 2013, J CHILD NEUROL, V28, P1027, DOI 10.1177/0883073813487598
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   De Giorgis V, 2013, SEIZURE-EUR J EPILEP, V22, P803, DOI 10.1016/j.seizure.2013.07.003
   de Oliveira MR, 2016, BBA-GEN SUBJECTS, V1860, P727, DOI 10.1016/j.bbagen.2016.01.017
   de Oliveira MR, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/140267
   De Pauw A, 2009, AM J PATHOL, V175, P927, DOI 10.2353/ajpath.2009.081155
   De Vadder F, 2016, CELL METAB, V24, P151, DOI 10.1016/j.cmet.2016.06.013
   Debbabi M, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17121973
   Depeint F, 2006, CHEM-BIOL INTERACT, V163, P94, DOI 10.1016/j.cbi.2006.04.014
   Desai MS, 2016, CELL, V167, P1339, DOI 10.1016/j.cell.2016.10.043
   Després JP, 2008, ARTERIOSCL THROM VAS, V28, P1039, DOI 10.1161/ATVBAHA.107.159228
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Devall M, 2014, EPIGENOMICS-UK, V6, P665, DOI [10.2217/EPI.14.50, 10.2217/epi.14.50]
   Devaraj S, 2008, J AM COLL NUTR, V27, P267, DOI 10.1080/07315724.2008.10719699
   Devries S, 2014, AM J MED, V127, P804, DOI 10.1016/j.amjmed.2014.04.003
   Dewulf EM, 2013, GUT, V62, P1112, DOI 10.1136/gutjnl-2012-303304
   Dillon SM, 2017, AIDS, V31, P510, DOI 10.1097/QAD.0000000000001366
   Due A, 2008, AM J CLIN NUTR, V87, P855, DOI 10.1093/ajcn/87.4.855
   Duthie SJ, 1996, CANCER RES, V56, P1291
   Engelhard YN, 2006, AM HEART J, V151, DOI 10.1016/j.ahj.2005.05.008
   Estruch R, 2013, NEW ENGL J MED, V368, P1279, DOI 10.1056/NEJMoa1200303
   Everts HB, 2002, IUBMB LIFE, V53, P295, DOI 10.1080/15216540213465
   Fabiani R, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092056
   Fan HL, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.00252
   Fan J, 2014, NATURE, V510, P298, DOI 10.1038/nature13236
   Farag HAM, 2018, DIABETOL METAB SYNDR, V10, DOI 10.1186/s13098-018-0384-8
   Fernandez-Mejia C, 2005, J NUTR BIOCHEM, V16, P424, DOI 10.1016/j.jnutbio.2005.03.018
   Fillmore N, 2014, BRIT J PHARMACOL, V171, P2080, DOI 10.1111/bph.12475
   Finicelli M, 2019, J CELL PHYSIOL, V234, P5807, DOI 10.1002/jcp.27506
   Finkel T, 2009, NATURE, V460, P587, DOI 10.1038/nature08197
   Flachs P, 2005, DIABETOLOGIA, V48, P2365, DOI 10.1007/s00125-005-1944-7
   Food and Agriculture Organization World Health Organization, 2006, PROB FOOD HLTH NUTR
   Food and Nutrition Board/Institute of Medicine, 2001, Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc
   Fujita K, 2006, CIRC J, V70, P1437, DOI 10.1253/circj.70.1437
   Fujita N, 2011, HEPATOL RES, V41, P287, DOI 10.1111/j.1872-034X.2011.00787.x
   Gallagher IJ, 2010, GENOME MED, V2, DOI 10.1186/gm130
   Garone C, 2013, JAMA NEUROL, V70, P1177, DOI 10.1001/jamaneurol.2013.3197
   Cano PG, 2013, OBESITY, V21, P2310, DOI 10.1002/oby.20330
   Gazdar AF, 2017, NAT REV CANCER, V17, P725, DOI [10.1038/nrc.2017.106, 10.1038/nrc.2017.87]
   Geiger J, 2017, CELL MOL LIFE SCI, V74, P631, DOI 10.1007/s00018-016-2342-7
   Geto Z, 2020, J INFLAMM RES, V13, P97, DOI 10.2147/JIR.S232009
   Ghavipour M, 2015, CLIN NUTR, V34, P805, DOI 10.1016/j.clnu.2014.10.012
   Gilijamse PW, 2020, NPJ BIOFILMS MICROME, V6, DOI 10.1038/s41522-020-0127-0
   Gillingham LG, 2011, LIPIDS, V46, P209, DOI 10.1007/s11745-010-3524-y
   Giordano C, 2014, FRONT NEUROL, V5, DOI 10.3389/fneur.2014.00063
   Godala M, 2017, ADV CLIN EXP MED, V26, P581, DOI 10.17219/acem/62453
   Gómez-Valadés AG, 2017, CURR DIABETES REV, V13, P370, DOI 10.2174/1573399812666151012115229
   Goncalves A, 2017, CURR OPIN CLIN NUTR, V20, P492, DOI 10.1097/MCO.0000000000000412
   González-Barroso MM, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003850
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Guerendiain M, 2017, CLIN NUTR, V36, P209, DOI 10.1016/j.clnu.2015.11.001
   Gunes S, 2017, BIOL TRACE ELEM RES, V177, P107, DOI 10.1007/s12011-016-0858-1
   Haack TB, 2010, NAT GENET, V42, P1131, DOI 10.1038/ng.706
   Hall AB, 2017, NAT REV GENET, V18, DOI 10.1038/nrg.2017.63
   Hamanaka RB, 2010, TRENDS BIOCHEM SCI, V35, P505, DOI 10.1016/j.tibs.2010.04.002
   Hammerling Ulrich, 2016, Subcell Biochem, V81, P201
   Han GM, 2017, EUR J INTEGR MED, V13, P34, DOI 10.1016/j.eujim.2017.07.002
   Han GM, 2016, NUTR RES, V36, P402, DOI 10.1016/j.nutres.2016.01.003
   Hasani M, 2018, HORM METAB RES, V50, P715, DOI 10.1055/a-0749-6655
   Hemingway C, 2001, PEDIATRICS, V108, P898, DOI 10.1542/peds.108.4.898
   Heng K. S., 2015, Malaysian Journal of Nutrition, V21, P231
   Henique C, 2010, J BIOL CHEM, V285, P36818, DOI 10.1074/jbc.M110.170431
   Hirschey MD, 2011, MOL CELL, V44, P177, DOI 10.1016/j.molcel.2011.07.019
   Holm T, 2001, TRANSPLANTATION, V72, P706, DOI 10.1097/00007890-200108270-00025
   Hu J, 2018, REGUL TOXICOL PHARM, V95, P412, DOI 10.1016/j.yrtph.2018.03.019
   Hughes SD, 2014, J NEUROCHEM, V129, P426, DOI 10.1111/jnc.12646
   Imamura F, 2015, LANCET GLOB HEALTH, V3, pE132, DOI 10.1016/S2214-109X(14)70381-X
   Jang H, 2020, CLIN NUTR, V39, P765, DOI 10.1016/j.clnu.2019.03.032
   Janiszewski PM, 2009, OBESITY, V17, pS3, DOI 10.1038/oby.2009.382
   Jayarathne Shasika, 2017, Prev Nutr Food Sci, V22, P251, DOI 10.3746/pnf.2017.22.4.251
   Jiang W, 2016, WORLD J GASTROENTERO, V22, P10180, DOI 10.3748/wjg.v22.i46.10180
   Joseph SV, 2016, CRIT REV FOOD SCI, V56, P419, DOI 10.1080/10408398.2013.767221
   Kadooka Y, 2013, BRIT J NUTR, V110, P1696, DOI 10.1017/S0007114513001037
   Kanagasabai T, 2019, METAB SYNDR RELAT D, V17, P29, DOI 10.1089/met.2018.0080
   Kang CH, 2012, ANN NY ACAD SCI, V1271, P110, DOI 10.1111/j.1749-6632.2012.06738.x
   Karimi M, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0225857
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Katzmarzyk PT, 2003, MED SCI SPORT EXER, V35, P1703, DOI 10.1249/01.MSS.0000089337.73244.9B
   Kelley DE, 2002, DIABETES, V51, P2944, DOI 10.2337/diabetes.51.10.2944
   Kerr JS, 2017, TRENDS NEUROSCI, V40, P151, DOI 10.1016/j.tins.2017.01.002
   Kim EJ, 2012, J NUTR BIOCHEM, V23, P1552, DOI 10.1016/j.jnutbio.2011.10.008
   Kim JA, 2008, CIRC RES, V102, P401, DOI 10.1161/CIRCRESAHA.107.165472
   Kim J, 2016, PUBLIC HEALTH, V135, P30, DOI 10.1016/j.puhe.2016.01.002
   Kobyliak N, 2018, DIABETES METAB SYND, V12, P617, DOI 10.1016/j.dsx.2018.04.015
   Koekkoek WAC, 2016, NUTR CLIN PRACT, V31, P457, DOI 10.1177/0884533616653832
   Kong KW, 2010, MOLECULES, V15, P959, DOI 10.3390/molecules15020959
   Kowaltowski AJ, 2009, FREE RADICAL BIO MED, V47, P333, DOI 10.1016/j.freeradbiomed.2009.05.004
   Krebs M, 2005, DIABETES OBES METAB, V7, P621, DOI 10.1111/j.1463-1326.2004.00439.x
   Kuszak AJ, 2018, ANNU REV PATHOL-MECH, V13, P163, DOI 10.1146/annurev-pathol-020117-043644
   Laclaustra M, 2009, CIRC-CARDIOVASC QUAL, V2, P369, DOI 10.1161/CIRCOUTCOMES.108.831552
   Lane N, 2010, NATURE, V467, P929, DOI 10.1038/nature09486
   Lanza IR, 2013, AM J PHYSIOL-ENDOC M, V304, pE1391, DOI 10.1152/ajpendo.00584.2012
   Lassenius MI, 2011, DIABETES CARE, V34, P1809, DOI 10.2337/dc10-2197
   Lawson LD, 2018, NUTRIENTS, V10, DOI 10.3390/nu10070812
   Leckey JJ, 2018, FASEB J, V32, P2979, DOI 10.1096/fj.201700993R
   Lee CG, 2019, J NUTR BIOCHEM, V64, P13, DOI 10.1016/j.jnutbio.2018.09.014
   Lee HS, 2016, J MED FOOD, V19, P823, DOI 10.1089/jmf.2016.3674
   Lee IC, 2014, FOOD CHEM TOXICOL, V63, P174, DOI 10.1016/j.fct.2013.11.006
   Lee KW, 2014, J MED FOOD, V17, P43, DOI 10.1089/jmf.2013.3049
   Lee S, 2018, MOL CELLS, V41, P1000, DOI 10.14348/molcells.2018.0438
   Leguisamo NM, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-100
   Lepretti M, 2018, NUTRIENTS, V10, DOI 10.3390/nu10030350
   Li WS, 2017, CHEM-BIOL INTERACT, V261, P27, DOI 10.1016/j.cbi.2016.11.021
   Liesa M, 2013, CELL METAB, V17, P491, DOI 10.1016/j.cmet.2013.03.002
   Liguori A, 2013, J TRADIT CHIN MED, V33, P322, DOI 10.1016/S0254-6272(13)60173-9
   Lill R, 2008, ANNU REV BIOCHEM, V77, P669, DOI 10.1146/annurev.biochem.76.052705.162653
   Lim JH, 2013, J BIOL CHEM, V288, P7117, DOI 10.1074/jbc.M112.415729
   Linseisen J, 2009, EUR J CLIN NUTR, V63, pS61, DOI 10.1038/ejcn.2009.75
   Lionetti L, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0092753
   Liu R, 2020, J NUTR BIOCHEM, V79, DOI 10.1016/j.jnutbio.2019.108330
   Locke A, 2018, AM FAM PHYSICIAN, V97, P721
   Lomb DJ, 2010, BBA-PROTEINS PROTEOM, V1804, P1652, DOI 10.1016/j.bbapap.2009.11.021
   Lombard DB, 2008, J INTERN MED, V263, P128, DOI 10.1111/j.1365-2796.2007.01902.x
   Lombard DB, 2007, MOL CELL BIOL, V27, P8807, DOI 10.1128/MCB.01636-07
   López-Crisosto C, 2015, BBA-MOL BASIS DIS, V1852, P2096, DOI 10.1016/j.bbadis.2015.07.011
   Lorente-Cebrián S, 2009, CLIN SCI, V117, P243, DOI 10.1042/CS20090020
   Lu C, 2012, CELL METAB, V16, P9, DOI 10.1016/j.cmet.2012.06.001
   Marques-Rocha JL, 2016, NUTRITION, V32, P48, DOI 10.1016/j.nut.2015.06.008
   Luvizotto RAM, 2015, HUM EXP TOXICOL, V34, P612, DOI 10.1177/0960327114551395
   Lymbury RS, 2010, MOL NUTR FOOD RES, V54, P1436, DOI 10.1002/mnfr.201000012
   Madreiter-Sokolowski CT, 2017, NUTRIENTS, V9, DOI 10.3390/nu9101117
   Magnúsdóttir S, 2015, FRONT GENET, V6, DOI 10.3389/fgene.2015.00148
   Mansego ML, 2011, J HYPERTENS, V29, P492, DOI 10.1097/HJH.0b013e328341f1b2
   Manzetti S, 2014, BIOCHEMISTRY-US, V53, P821, DOI 10.1021/bi401618y
   Marcason Wendy, 2015, J Acad Nutr Diet, V115, P1744, DOI 10.1016/j.jand.2015.08.002
   Mathewson ND, 2016, NAT IMMUNOL, V17, P505, DOI 10.1038/ni.3400
   Matos HR, 2006, BRAZ J MED BIOL RES, V39, P203, DOI 10.1590/S0100-879X2006000200006
   Matsumoto S, 2016, J NUTR, V146, p427S, DOI 10.3945/jn.114.202424
   McCarty MF, 2000, MED HYPOTHESES, V55, P189, DOI 10.1054/mehy.1999.1011
   McDonald TJW, 2017, EPILEPSY CURR, V17, P346, DOI 10.5698/1535-7597.17.6.346
   McLelland GL, 2018, ELIFE, V7, DOI 10.7554/eLife.32866
   Menotti A, 2015, NUTR METAB CARDIOVAS, V25, P245, DOI 10.1016/j.numecd.2014.12.001
   Mermigkis C, 2013, SLEEP BREATH, V17, P1129, DOI 10.1007/s11325-013-0816-5
   Meyer JN, 2017, TOXICOLOGY, V391, P42, DOI 10.1016/j.tox.2017.07.019
   Micó V, 2016, PLANT FOOD HUM NUTR, V71, P102, DOI 10.1007/s11130-016-0534-9
   Mishra S, 2019, LIFE SCI, V218, P96, DOI 10.1016/j.lfs.2018.12.035
   Monteith GR, 2017, NAT REV CANCER, V17, P367, DOI 10.1038/nrc.2017.18
   Moreno-Indias I, 2016, FOOD FUNCT, V7, P1775, DOI [10.1039/C5FO00886G, 10.1039/c5fo00886g]
   Motawi TMK, 2009, J PHARM PHARMACOL, V61, P1339, DOI [10.1211/jpp/61.10.0010, 10.1211/jpp.61.10.0010]
   Mousavi SM, 2019, OBES REV, V20, P487, DOI 10.1111/obr.12775
   Mueller AS, 2006, J NUTR BIOCHEM, V17, P548, DOI 10.1016/j.jnutbio.2005.10.006
   Muller FL, 2004, J BIOL CHEM, V279, P49064, DOI 10.1074/jbc.M407715200
   Murphy MP, 2009, BIOCHEM J, V417, P1, DOI 10.1042/BJ20081386
   Nakamura S, 2009, J BIOL CHEM, V284, P14809, DOI 10.1074/jbc.M901488200
   Neal EG, 2010, J HUM NUTR DIET, V23, P113, DOI 10.1111/j.1365-277X.2010.01043.x
   Negishi H, 2004, J NUTR, V134, P38, DOI 10.1093/jn/134.1.38
   Nisoli E, 2007, CIRC RES, V100, P795, DOI 10.1161/01.RES.0000259591.97107.6c
   North BJ, 2004, GENOME BIOL, V5, DOI 10.1186/gb-2004-5-5-224
   Nunnari J, 2012, CELL, V148, P1145, DOI 10.1016/j.cell.2012.02.035
   O'Mahoney LL, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0740-x
   Obri A, 2019, CELL STRESS, V3, P208, DOI 10.15698/cst2019.07.191
   Olsen RKJ, 2007, BRAIN, V130, P2045, DOI 10.1093/brain/awm135
   Onakpoya I, 2014, NUTR METAB CARDIOVAS, V24, P823, DOI 10.1016/j.numecd.2014.01.016
   Ortega FJ, 2015, J NUTR BIOCHEM, V26, P1095, DOI 10.1016/j.jnutbio.2015.05.001
   Palomer X, 2018, TRENDS ENDOCRIN MET, V29, P178, DOI 10.1016/j.tem.2017.11.009
   Parikh S, 2009, CURR TREAT OPTION N, V11, P414, DOI 10.1007/s11940-009-0046-0
   Parish R., 2005, CURR DIABETES REP, V5, P177, DOI DOI 10.1007/S11892-005-0006-3
   Pastore A, 2014, J INHERIT METAB DIS, V37, P125, DOI 10.1007/s10545-013-9605-3
   Patel A, 2010, EPILEPSIA, V51, P1277, DOI 10.1111/j.1528-1167.2009.02488.x
   Peeters AV, 2008, HUM GENET, V124, P431, DOI 10.1007/s00439-008-0567-8
   Peng W, 2019, BIOL TRACE ELEM RES, V191, P189, DOI 10.1007/s12011-018-1599-0
   Perdomo L, 2015, CARDIOVASC DIABETOL, V14, DOI 10.1186/s12933-015-0237-9
   Pérez-Martínez P, 2017, NUTR REV, V75, P307, DOI 10.1093/nutrit/nux014
   Perry RJ, 2016, NATURE, V534, P213, DOI 10.1038/nature18309
   Peterson CT, 2015, CLIN EXP IMMUNOL, V179, P363, DOI 10.1111/cei.12474
   Pheiffer C, 2016, J PHYSIOL BIOCHEM, V72, P25, DOI 10.1007/s13105-015-0454-4
   Pieczenik SR, 2007, EXP MOL PATHOL, V83, P84, DOI 10.1016/j.yexmp.2006.09.008
   Piletic K, 2016, ARCH TOXICOL, V90, P2405, DOI 10.1007/s00204-016-1815-7
   Pirola L, 2004, DIABETOLOGIA, V47, P170, DOI 10.1007/s00125-003-1313-3
   Popkin BM, 2010, NUTR REV, V68, P439, DOI 10.1111/j.1753-4887.2010.00304.x
   Power GW, 1997, J NUTR, V127, P2142, DOI 10.1093/jn/127.11.2142
   Prasad P, 2016, DIABETES METAB SYND, V10, P105, DOI 10.1016/j.dsx.2015.02.014
   Prashanth A, 2014, NUTR METAB, V11, DOI 10.1186/1743-7075-11-45
   Prashanth Lingamaneni., 2015, J DR NTR U HLTH SCI, V4, P75
   Quesada I, 2020, CURR HYPERTENS REP, V22, DOI 10.1007/s11906-019-1009-9
   Raymond MR, 2016, J OCCUP ENVIRON MED, V58, P676, DOI 10.1097/JOM.0000000000000757
   Riad K, 2018, FRONT NUTR, V5, DOI 10.3389/fnut.2018.00122
   Ricca C, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19061672
   Ried K, 2016, INTEGR BLOOD PRESS C, V9, P9, DOI 10.2147/IBPC.S93335
   Ristow M, 2014, NAT MED, V20, P709, DOI 10.1038/nm.3624
   Ristow M, 2010, EXP GERONTOL, V45, P410, DOI 10.1016/j.exger.2010.03.014
   Ro S, 2013, CELL RES, V23, P759, DOI 10.1038/cr.2013.37
   Roberfroid M, 2010, BRIT J NUTR, V104, pS1, DOI 10.1017/S0007114510003363
   Rocha M, 2014, MED RES REV, V34, P160, DOI 10.1002/med.21285
   Rocha M, 2013, CURR PHARM DESIGN, V19, P5730, DOI 10.2174/13816128113199990373
   Rodríguez-Monforte M, 2017, EUR J NUTR, V56, P925, DOI 10.1007/s00394-016-1305-y
   Roh T, 2018, FOOD CHEM TOXICOL, V114, P11, DOI 10.1016/j.fct.2018.02.017
   Ruz M, 2019, BIOL TRACE ELEM RES, V188, P177, DOI 10.1007/s12011-018-1611-8
   Sacks D, 2018, INT J STROKE, V13, P612, DOI [10.1177/1747493018778713, 10.1016/j.jvir.2017.11.026]
   Sagun KC, 2005, FASEB J, V19, P1657, DOI 10.1096/fj.05-4107com
   Saibandith B, 2017, MOLECULES, V22, DOI 10.3390/molecules22071082
   Saini RK, 2017, 3 BIOTECH, V7, DOI 10.1007/s13205-017-0666-0
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sargsyan E, 2016, BBA-MOL CELL BIOL L, V1861, P1151, DOI 10.1016/j.bbalip.2016.06.012
   Sato Y, 2000, MUSCLE NERVE, V23, P1069, DOI 10.1002/1097-4598(200007)23:7<1069::AID-MUS9>3.0.CO;2-0
   Schlicker C, 2008, J MOL BIOL, V382, P790, DOI 10.1016/j.jmb.2008.07.048
   Schoeler NE, 2020, EPILEPSIA OPEN, V5, P73, DOI 10.1002/epi4.12371
   Schwer B, 2008, CELL METAB, V7, P104, DOI 10.1016/j.cmet.2007.11.006
   Schwingshackl L, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-154
   Sergi D, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00532
   Shang A, 2019, FOODS, V8, DOI 10.3390/foods8070246
   Shenkin A, 2006, CLIN NUTR, V25, P1, DOI 10.1016/j.clnu.2005.11.006
   Shin IS, 2013, FOOD CHEM TOXICOL, V62, P506, DOI 10.1016/j.fct.2013.09.012
   Siddiqui S, 2013, TOXICOL APPL PHARM, V273, P314, DOI 10.1016/j.taap.2013.09.004
   Silvagno F, 2017, MOL CELL ENDOCRINOL, V450, P24, DOI 10.1016/j.mce.2017.04.013
   Simopoulos AP, 2006, BIOMED PHARMACOTHER, V60, P502, DOI 10.1016/j.biopha.2006.07.080
   Sliter DA, 2018, NATURE, V561, P258, DOI 10.1038/s41586-018-0448-9
   Smith RL, 2018, ENDOCR REV, V39, P489, DOI 10.1210/er.2017-00211
   Smits LP, 2013, GASTROENTEROLOGY, V145, P946, DOI 10.1053/j.gastro.2013.08.058
   Snow JW, 2013, RNA BIOL, V10, P1107, DOI 10.4161/rna.24909
   Sonnenburg ED, 2016, NATURE, V529, P212, DOI 10.1038/nature16504
   Spinelli JB, 2018, NAT CELL BIOL, V20, P745, DOI 10.1038/s41556-018-0124-1
   Sulaiman M, 2010, AM J PHYSIOL-HEART C, V298, pH833, DOI 10.1152/ajpheart.00418.2009
   Sultana MR, 2016, LIFE SCI, V164, P42, DOI 10.1016/j.lfs.2016.08.030
   Sun C, 2007, CELL METAB, V6, P307, DOI 10.1016/j.cmet.2007.08.014
   Sun K, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047791
   Supakul L, 2014, EUR J NUTR, V53, P919, DOI 10.1007/s00394-013-0595-6
   Suzuki MM, 2008, NAT REV GENET, V9, P465, DOI 10.1038/nrg2341
   Taivassalo T, 2001, ANN NEUROL, V50, P133, DOI 10.1002/ana.1050
   Tarnopolsky MA, 2011, AMINO ACIDS, V40, P1397, DOI 10.1007/s00726-011-0876-4
   The World Health Organization, Healthy diet
   Title AC, 2015, J BIOL CHEM, V290, P23680, DOI 10.1074/jbc.M115.676734
   Togliatto G, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18091988
   Tomaro-Duchesneau C, 2014, APPL MICROBIOL BIOT, V98, P115, DOI 10.1007/s00253-013-5252-8
   Diaz-Gerevini GT, 2016, NUTRITION, V32, P174, DOI 10.1016/j.nut.2015.08.017
   Tomé-Carneiro J, 2013, PHARMACOL RES, V72, P69, DOI 10.1016/j.phrs.2013.03.011
   Tortosa-Caparrós E, 2017, CRIT REV FOOD SCI, V57, P3421, DOI 10.1080/10408398.2015.1126549
   Tsuneki Hiroshi, 2004, BMC Pharmacology, V4, P18, DOI 10.1186/1471-2210-4-18
   Tutunchi H, 2020, ADV NUTR, V11, P864, DOI 10.1093/advances/nmaa013
   Urpi-Sarda M, 2012, PHARMACOL RES, V65, P577, DOI 10.1016/j.phrs.2012.03.006
   Vafeiadou K, 2015, AM J CLIN NUTR, V102, P40, DOI 10.3945/ajcn.114.097089
   van Dam RM, 2002, ANN INTERN MED, V136, P201, DOI 10.7326/0003-4819-136-3-200202050-00008
   Vang O, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019881
   Veech RL, 2004, PROSTAG LEUKOTR ESS, V70, P309, DOI 10.1016/j.plefa.2003.09.007
   Vidali S, 2015, INT J BIOCHEM CELL B, V63, P55, DOI 10.1016/j.biocel.2015.01.022
   Wai T, 2016, TRENDS ENDOCRIN MET, V27, P105, DOI 10.1016/j.tem.2015.12.001
   Wan Y, 2019, GUT, V68, P1417, DOI 10.1136/gutjnl-2018-317609
   Wang CG, 2006, NAT CELL BIOL, V8, P1025, DOI 10.1038/ncb1468
   Wang SY, 2016, MOL MED REP, V14, P3086, DOI 10.3892/mmr.2016.5651
   Wang X, 2014, TOXICOL LETT, V224, P16, DOI 10.1016/j.toxlet.2013.10.005
   Warburton DER, 2006, CAN MED ASSOC J, V174, P801, DOI 10.1503/cmaj.051351
   Wei J, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0130876
   Wesselink E, 2019, CLIN NUTR, V38, P982, DOI 10.1016/j.clnu.2018.08.032
   Weyrich P, 2008, BMC MED GENET, V9, DOI 10.1186/1471-2350-9-100
   Wimalawansa SJ, 2018, J STEROID BIOCHEM, V175, P177, DOI 10.1016/j.jsbmb.2016.09.017
   Wojtczak L, 2003, BIOFACTORS, V17, P61, DOI 10.1002/biof.5520170107
   Wong SK, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00444
   Xiao HB, 2012, PHARMACOL REP, V64, P889, DOI 10.1016/S1734-1140(12)70883-6
   Yassour M, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0271-6
   Yin JL, 2019, ANAL CHEM, V91, P8415, DOI 10.1021/acs.analchem.9b01293
   Youle RJ, 2011, NAT REV MOL CELL BIO, V12, P9, DOI 10.1038/nrm3028
   Yousaf S, 2014, FOOD FUNCT, V5, P545, DOI 10.1039/c3fo60203f
   Yuzefovych L, 2010, AM J PHYSIOL-ENDOC M, V299, pE1096, DOI 10.1152/ajpendo.00238.2010
   Zang QS, 2012, AM J PHYSIOL-HEART C, V302, pH1847, DOI 10.1152/ajpheart.00203.2011
   Zeb I, 2018, CORONARY ARTERY DIS, V29, P325, DOI 10.1097/MCA.0000000000000587
   Zeng ZH, 2017, EXP CLIN ENDOCR DIAB, V125, P610, DOI 10.1055/s-0043-101919
   Zhang L, 2012, CELL RES, V22, P107, DOI 10.1038/cr.2011.158
   Zhang LF, 2020, ANN TRANSL MED, V8, DOI 10.21037/atm.2019.10.113
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zhang YM, 2019, J ETHNOPHARMACOL, V231, P486, DOI 10.1016/j.jep.2018.11.030
   Zhao BT, 2017, FOOD CHEM TOXICOL, V109, P505, DOI 10.1016/j.fct.2017.09.050
   Zhao RZ, 2019, INT J MOL MED, V44, P3, DOI 10.3892/ijmm.2019.4188
   Zheng Z, 2015, MOL MED REP, V11, P4149, DOI 10.3892/mmr.2015.3318
   Zhou J, 2013, FREE RADICAL BIO MED, V65, P1548, DOI 10.1016/j.freeradbiomed.2013.07.012
   Zidani S, 2017, J NUTR BIOCHEM, V40, P164, DOI 10.1016/j.jnutbio.2016.11.001
NR 329
TC 33
Z9 38
U1 0
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2020
VL 12
IS 9
AR 2785
DI 10.3390/nu12092785
PG 38
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OF6UL
UT WOS:000581339900001
PM 32933003
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wei, J
   Sun, X
   Chen, YJ
   Li, YY
   Song, LQ
   Zhou, Z
   Xu, B
   Lin, Y
   Xu, SQ
AF Wei, Jie
   Sun, Xia
   Chen, Yajie
   Li, Yuanyuan
   Song, Liqiong
   Zhou, Zhao
   Xu, Bing
   Lin, Yi
   Xu, Shunqing
TI Perinatal exposure to bisphenol A exacerbates nonalcoholic
   steatohepatitis-like phenotype in male rat offspring fed on a high-fat
   diet
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
DE bisphenol A; steatosis; insulin resistance; oxidative stress;
   inflammation; fibrosis
ID HOMEOSTASIS MODEL ASSESSMENT; TYPE-2 DIABETES-MELLITUS; LIVER-DISEASE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; GENE-EXPRESSION; MOUSE-LIVER;
   PPAR-ALPHA; MICE; SENSITIVITY
AB Bisphenol A (BPA) is one of the environmental endocrine disrupting chemicals, which is present ubiquitously in daily life. Accumulating evidence indicates that exposure to BPA contributes to metabolic syndrome. In this study, we examined whether perinatal exposure to BPA predisposed offspring to fatty liver disease: the hepatic manifestation of metabolic syndrome. Wistar rats were exposed to 50 mu g/kg per day BPA or corn oil throughout gestation and lactation by oral gavage. Offspring were fed a standard chow diet (SD) or a high-fat diet (HFD) after weaning. Effects of BPA were assessed by examination of hepatic morphology, biochemical analysis, and the hepatic expression of genes and/or proteins involved in lipogenesis, fatty acid oxidation, gluconeogenesis, insulin signaling, inflammation, and fibrosis. On a SD, the offspring of rats exposed to BPA exhibited moderate hepatic steatosis and altered expression of insulin signaling elements in the liver, but with normal liver function. On a HFD, the offspring of rats exposed to BPA showed a nonalcoholic steatohepatitis-like phenotype, characterized by extensive accumulation of lipids, large lipid droplets, profound ballooning degeneration, impaired liver function, increased inflammation, and even mild fibrosis in the liver. Perinatal exposure to BPA worsened the hepatic damage caused by the HFD in the rat offspring. The additive effects of BPA correlated with higher levels of hepatic oxidative stress. Collectively, exposure to BPA may be a new risk factor for the development of fatty liver disease and further studies should assess whether this finding is also relevant to the human population.
C1 [Li, Yuanyuan; Song, Liqiong; Zhou, Zhao; Xu, Bing; Xu, Shunqing] Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, Minist Educ,Key Lab Environm & Hlth, Wuhan 430030, Peoples R China.
   [Li, Yuanyuan; Song, Liqiong; Zhou, Zhao; Xu, Bing; Xu, Shunqing] Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, Minist Environm Protect, Wuhan 430030, Peoples R China.
   [Li, Yuanyuan; Song, Liqiong; Zhou, Zhao; Xu, Bing; Xu, Shunqing] Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, State Key Lab Environm Hlth Incubating, Wuhan 430030, Peoples R China.
   [Sun, Xia; Chen, Yajie; Lin, Yi] Chinese Acad Sci, Inst Urban Environm, Dept Environm & Mol Toxicol, Key Lab Urban Environm & Hlth, Xiamen 361021, Peoples R China.
   [Wei, Jie] Xiamen Univ, Coll Med, Dept Basic Med Sci, Xiamen 361102, Peoples R China.
C3 Ministry of Education - China; Huazhong University of Science &
   Technology; Huazhong University of Science & Technology; Huazhong
   University of Science & Technology; Chinese Academy of Sciences;
   Institute of Urban Environment, CAS; Xiamen University
RP Xu, SQ (corresponding author), Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, Minist Educ,Key Lab Environm & Hlth, Wuhan 430030, Peoples R China.
EM ylin@iue.ac.cn; xust@hust.edu.cn
RI chen, yundai/I-4353-2019; œSun, Xia/F-9084-2018; Li,
   Yuanyuan/GRS-1755-2022
OI Li, Yuanyuan/0000-0003-4967-3890; Xu, Shunqing/0000-0002-7771-3821; Sun,
   Xia/0000-0001-7733-9502; Chen, Yajie/0000-0001-6567-0396
FU National Program on Key Basic Research Project of China (973 Program)
   [2012CB722401]; National Natural Science Foundation of China [81030051,
   21177046, 21207128]; R&D Special Fund for Public Welfare Industry
   (Environment) [201309048]; National Basic Research Development Program
   of China [2008CB418206]; Fundamental Research Funds for the Central
   Universities, Huazhong University of Science and Technology [2012QN240,
   2012TS072]; Natural Science Foundation of Fujian Province, China
   [2013J05033]
FX This work was supported by the National Program on Key Basic Research
   Project of China (973 Program) (2012CB722401), the National Natural
   Science Foundation of China (81030051, 21177046, and 21207128), the R&D
   Special Fund for Public Welfare Industry (Environment) (201309048), the
   National Basic Research Development Program of China (2008CB418206), the
   Fundamental Research Funds for the Central Universities, Huazhong
   University of Science and Technology (2012QN240 and 2012TS072), and the
   Natural Science Foundation of Fujian Province, China (2013J05033).
CR Alonso-Magdalena P, 2011, NAT REV ENDOCRINOL, V7, P346, DOI 10.1038/nrendo.2011.56
   Alonso-Magdalena P, 2010, ENVIRON HEALTH PERSP, V118, P1243, DOI 10.1289/ehp.1001993
   Avissar-Whiting M, 2010, REPROD TOXICOL, V29, P401, DOI 10.1016/j.reprotox.2010.04.004
   Azzalini L, 2010, HEPATOLOGY, V51, P1567, DOI 10.1002/hep.23516
   Batista TM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033814
   Bayol SA, 2010, ENDOCRINOLOGY, V151, P1451, DOI 10.1210/en.2009-1192
   Bernal AJ, 2010, BIRTH DEFECTS RES A, V88, P938, DOI 10.1002/bdra.20685
   Bonora E, 2000, DIABETES CARE, V23, P57, DOI 10.2337/diacare.23.1.57
   Chan SMH, 2013, DIABETES, V62, P2095, DOI 10.2337/db12-1397
   Chen H, 2005, DIABETES, V54, P1914, DOI 10.2337/diabetes.54.7.1914
   Cohen JC, 2011, SCIENCE, V332, P1519, DOI 10.1126/science.1204265
   Diamanti-Kandarakis E, 2009, ENDOCR REV, V30, P293, DOI 10.1210/er.2009-0002
   Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI23621
   Fan JG, 2005, J GASTROEN HEPATOL, V20, P1825, DOI 10.1111/j.1440-1746.2005.04058.x
   Farrell GC, 2006, HEPATOLOGY, V43, pS99, DOI 10.1002/hep.20973
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   Friedman TC, 2012, ENDOCRINOLOGY, V153, P5809, DOI 10.1210/en.2012-1750
   Hamaguchi M, 2005, ANN INTERN MED, V143, P722, DOI 10.7326/0003-4819-143-10-200511150-00009
   Huc L, 2012, TOXICOL IN VITRO, V26, P709, DOI 10.1016/j.tiv.2012.03.017
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   Lang IA, 2008, JAMA-J AM MED ASSOC, V300, P1303, DOI 10.1001/jama.300.11.1303
   Ma Y, 2013, DIABETOLOGIA, V56, P2059, DOI 10.1007/s00125-013-2944-7
   Marchesini G, 2005, CURR OPIN LIPIDOL, V16, P421, DOI 10.1097/01.mol.0000174153.53683.f2
   Marmugi A, 2012, HEPATOLOGY, V55, P395, DOI 10.1002/hep.24685
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McCurdy CE, 2009, J CLIN INVEST, V119, P323, DOI 10.1172/JCI32661
   MCGARRY JD, 1980, ANNU REV BIOCHEM, V49, P395, DOI 10.1146/annurev.bi.49.070180.002143
   Nagakawa Y, 2005, HEPATOLOGY, V42, P208, DOI 10.1002/hep.20755
   Oben JA, 2010, J HEPATOL, V52, P913, DOI 10.1016/j.jhep.2009.12.042
   Reddy JK, 2001, AM J PHYSIOL-GASTR L, V281, pG1333, DOI 10.1152/ajpgi.2001.281.6.G1333
   REDGRAVE T G, 1970, Journal of Clinical Investigation, V49, P465, DOI 10.1172/JCI106255
   Rubin BS, 2009, MOL CELL ENDOCRINOL, V304, P55, DOI 10.1016/j.mce.2009.02.023
   Saal FSV, 2012, MOL CELL ENDOCRINOL, V354, P74, DOI 10.1016/j.mce.2012.01.001
   Santra A, 2007, TOXICOL APPL PHARM, V220, P146, DOI 10.1016/j.taap.2006.12.029
   Shankar A, 2012, ENVIRON HEALTH PERSP, V120, P1297, DOI 10.1289/ehp.1104114
   Shen L, 2014, TOXICOL APPL PHARM, V274, P263, DOI 10.1016/j.taap.2013.11.009
   Shimomura I, 2000, MOL CELL, V6, P77, DOI 10.1016/S1097-2765(00)00009-5
   Singh S, 2012, INT J MOL SCI, V13, P10143, DOI 10.3390/ijms130810143
   Somm E, 2009, ENVIRON HEALTH PERSP, V117, P1549, DOI 10.1289/ehp.11342
   Tan HH, 2009, J IMMUNOTOXICOL, V6, P266, DOI 10.1080/15476910903241704
   Tomaru M, 2007, INT J MOL MED, V19, P17
   Tong M, 2009, J ALZHEIMERS DIS, V17, P827, DOI 10.3233/JAD-2009-1115
   Utzschneider KM, 2006, J CLIN ENDOCR METAB, V91, P4753, DOI 10.1210/jc.2006-0587
   Veiga-Lopez A, 2013, ENDOCRINOLOGY, V154, P1873, DOI 10.1210/en.2012-2129
   Wei J, 2011, ENDOCRINOLOGY, V152, P3049, DOI 10.1210/en.2011-0045
NR 45
TC 91
Z9 98
U1 3
U2 43
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD SEP
PY 2014
VL 222
IS 3
BP 313
EP 325
DI 10.1530/JOE-14-0356
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AP2CW
UT WOS:000341881100008
PM 25112833
OA Bronze
DA 2025-06-11
ER

PT J
AU Ibrahim, MA
   Amin, EF
   Ibrahim, SA
   Abdelzaher, WY
   Abdelrahman, AM
AF Ibrahim, Mohamed A.
   Amin, Entesar F.
   Ibrahim, Salwa A.
   Abdelzaher, Walaa Y.
   Abdelrahman, Aly M.
TI Montelukast and irbesartan ameliorate metabolic and hepatic disorders in
   fructose-induced metabolic syndrome in rats
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Fructose-induced metabolic syndrome; Montelukast; Irbesartan
ID INSULIN-RESISTANCE; DEFENSE SYSTEM; LIVER; ANTAGONIST; THERAPY; DISEASE;
   OBESITY; DAMAGE; MODEL
AB Metabolic syndrome (MetS) is a global health problem Elucidation of the role of 5- lipooxygenase/leukotriene pathway and renin angiotensin system in the pathogenesis of MetS suggests a variety of potential therapies worthy of testing. The present work investigated the effect of montelukast, a leukotriene antagonist and/or irbesartan, an angiotensin II-receptor blocker, in the prevention of fructose induced MetS in rats. Rats were allocated into 9 groups and treated for 6 weeks as follow: normal control; MetS group (received 20% fructose); MetS + montelukast groups (treated with montelukast, 5, 10, and 20 mg/kg/day, respectively); MetS + irbesartan groups (treated withirbesartan 15, 30, and 45 mg/kg/day, respectively); and MetS + montelukast + irbesartan group (co treated with montelukast 5 mg/kg plus irbesartan 15 mg/g). Metabolic parameters (visceral fat index, liver index, insulin resistance, and serum lipid profile), oxidative stress markers (malondialdehyde, reduced glutathione, and catalase), and inflammatory mediators (tumor necrosis factor-alpha, and uric acid) were measured. Expression of caspase-3 in hepatic tissues was detected by immunohistochemistry. Liver injury was evaluated by histopathological examination and serum alanine aminotransferase (ALT). Montelukast, irbesartan, and their combination caused significant attenuation in metabolic and hepatic disorders. Their effect was associated with attenuation of oxidative stress markers, inflammatory mediators, and caspase-3 expression. This study highlighted the protective effects of montelukast and irbesartan against fructose-induced metabolic and hepatic disorders. The protective effect of either drug relics, at least in part, on their antioxidant and antiinflammatory effect, as well as on the reduction of caspase-3 expression in hepatic tissue. (C) 2013 Elsevier B.V. All rights reserved
C1 [Ibrahim, Mohamed A.; Amin, Entesar F.; Ibrahim, Salwa A.; Abdelzaher, Walaa Y.; Abdelrahman, Aly M.] Menia Univ, Fac Med, Dept Pharmacol, El Minia, Egypt.
C3 Egyptian Knowledge Bank (EKB); Minia University
RP Ibrahim, MA (corresponding author), Menia Univ, Fac Med, Dept Pharmacol, El Minia, Egypt.
EM maim69@yahoo.com
RI Abdelzaher, Walaa/W-1092-2019
OI Ibrahim, Mohamed/0000-0002-3203-944X; Afify, Entesar/0000-0003-2963-5555
CR Anjaneyulu M, 2004, AM J NEPHROL, V24, P488, DOI 10.1159/000080722
   Astrup A, 2000, Obes Rev, V1, P57, DOI 10.1046/j.1467-789x.2000.00013.x
   Benninger MS, 2009, CLIN MED INSIGHTS-TH, V1, P1253
   Buege J A, 1978, Methods Enzymol, V52, P302
   Capra V, 2004, PHARMACOL RES, V50, P1, DOI 10.1016/j.phrs.2003.12.012
   Coskun AK, 2011, THESCIENTIFICWORLDJO, V11, P1341, DOI 10.1100/tsw.2011.122
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   Dengiz GO, 2007, J PHARMACOL SCI, V105, P94, DOI 10.1254/jphs.FP0070122
   Ding WX, 2004, J CELL MOL MED, V8, P445, DOI 10.1111/j.1582-4934.2004.tb00469.x
   Faure P, 1999, DIABETES, V48, P353, DOI 10.2337/diabetes.48.2.353
   Hansen PA, 1997, AM J PHYSIOL-REG I, V273, pR1704, DOI 10.1152/ajpregu.1997.273.5.R1704
   Hansson L, 1999, LANCET, V353, P611, DOI 10.1016/S0140-6736(98)05012-0
   Ibrahim M, 2011, EUR J PHARMACOL, V659, P289, DOI 10.1016/j.ejphar.2011.03.016
   Khan BV, 2001, J AM COLL CARDIOL, V38, P1662, DOI 10.1016/S0735-1097(01)01615-1
   Kose E, 2012, SCI WORLD J, DOI 10.1100/2012/987508
   Martínez-Clemente M, 2011, CURR OPIN CLIN NUTR, V14, P347, DOI 10.1097/MCO.0b013e32834777fa
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Nakagawa T, 2006, AM J PHYSIOL-RENAL, V290, pF625, DOI 10.1152/ajprenal.00140.2005
   Ogihara T, 2008, HYPERTENSION, V51, P393, DOI 10.1161/HYPERTENSIONAHA.107.098475
   Otunctemur A, 2013, RENAL FAILURE, V35, P403, DOI 10.3109/0886022X.2012.761040
   Özkan E, 2010, PANCREAS, V39, P1041, DOI 10.1097/MPA.0b013e3181db2dfd
   Panchal SK, 2012, J NUTR, V142, P1026, DOI 10.3945/jn.111.157263
   Parhofer KG, 2007, CARDIOVASC DIABETOL, V6, DOI 10.1186/1475-2840-6-36
   Rector RS, 2008, WORLD J GASTROENTERO, V14, P185, DOI 10.3748/wjg.14.185
   Riccioni G, 2007, CURR MED CHEM, V14, P1966
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Stellato D, 2012, INTERN EMERG MED, V7, P5, DOI 10.1007/s11739-011-0642-3
   Takai S, 2011, J PHARMACOL SCI, V116, P309, DOI 10.1254/jphs.11053FP
   Tugtepe H, 2007, EUR J PHARMACOL, V557, P69, DOI 10.1016/j.ejphar.2006.11.009
NR 29
TC 27
Z9 29
U1 0
U2 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD FEB 5
PY 2014
VL 724
BP 204
EP 210
DI 10.1016/j.ejphar.2013.12.024
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AA5LM
UT WOS:000331140500025
PM 24370493
DA 2025-06-11
ER

PT J
AU Lankinen, M
   Schwab, U
   Gopalacharyulu, PV
   Seppänen-Laakso, T
   Yetukuri, L
   Sysi-Aho, M
   Kallio, P
   Suortti, T
   Laaksonen, DE
   Gylling, H
   Poutanen, K
   Kolehmainen, M
   Oresic, M
AF Lankinen, M.
   Schwab, U.
   Gopalacharyulu, P. V.
   Seppanen-Laakso, T.
   Yetukuri, L.
   Sysi-Aho, M.
   Kallio, P.
   Suortti, T.
   Laaksonen, D. E.
   Gylling, H.
   Poutanen, K.
   Kolehmainen, M.
   Oresic, M.
TI Dietary carbohydrate modification alters serum metabolic profiles in
   individuals with the metabolic syndrome
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Metabolic syndrome; Diet; Metabolomics; Lipidomics
ID WHOLE-GRAIN; CARDIOVASCULAR-DISEASE; INSULIN SENSITIVITY;
   LIPID-PEROXIDATION; GENE-EXPRESSION; ADIPOSE-TISSUE; INFLAMMATION;
   MARKERS; FIBER; SECRETION
AB Background and aims: Whole-grain cereals and diets with a low glycemic index may protect against the development of type 2 diabetes and heart disease, but the mechanisms are poorly understood. We studied the effect of carbohydrate modification on serum metabolic profiles, including lipids and branched chain amino acids, and dependencies between these and specific gene expression pathways in adipose tissue.
   Methods and results: Twenty subjects with metabolic syndrome were selected from the larger FUNGENUT study population, randomized either to a diet high in oat and wheat bread and potato (OWP) or rye bread and pasta (RP). Serum metabolomics analyses were performed using ultra-performance liquid chromatography coupled to electrospray ionization mass spectrometry (UPLC/MS), gas chromatography (GC) and UPLC.
   In the OWP group multiple proinflammatory lysophosphatidylcholines increased, while in the RP group docosahexaenoic acid (DHA 22:6n-3) increased and isoleucine decreased. mRNA expression of stress reactions- and adipose tissue differentiation-related genes were up-regulated in adipose tissue in the OWP group. In the RP group, however, pathways related to stress reactions and insulin signaling and energy metabolism were down-regulated. The lipid profiles had the strongest association with the changes in the adipose tissue differentiation pathway when using the elastic net regression model of the lipidomic profiles on selected pathways. Conclusion: Our results suggest that the dietary carbohydrate modification alters the serum metabolic profile, especially in lysoPC species, and may, thus, contribute to proinflammatory processes which in turn promote adverse changes in insulin and glucose metabolism. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Lankinen, M.; Schwab, U.; Gylling, H.] Univ Kuopio, Dept Clin Nutr, Sch Publ Hlth & Clin Nutr, FI-70211 Kuopio, Finland.
   [Lankinen, M.; Gopalacharyulu, P. V.; Seppanen-Laakso, T.; Yetukuri, L.; Sysi-Aho, M.; Suortti, T.; Poutanen, K.; Oresic, M.] VTT Tech Res Ctr Finland, Espoo, Finland.
   [Schwab, U.; Laaksonen, D. E.; Gylling, H.] Kuopio Univ Hosp, Inst Clin Med, SF-70210 Kuopio, Finland.
   [Kallio, P.; Poutanen, K.; Kolehmainen, M.] Univ Kuopio, Sch Publ Hlth & Clin Nutr, Food & Hlth Res Ctr, Dept Clin Nutr, FI-70211 Kuopio, Finland.
   [Laaksonen, D. E.] Univ Kuopio, Inst Biomed, FI-70211 Kuopio, Finland.
C3 University of Eastern Finland; VTT Technical Research Center Finland;
   University of Eastern Finland; University of Eastern Finland Hospital;
   Kuopio University Hospital; University of Eastern Finland; University of
   Eastern Finland
RP Lankinen, M (corresponding author), Univ Kuopio, Dept Clin Nutr, Sch Publ Hlth & Clin Nutr, POB 1627, FI-70211 Kuopio, Finland.
EM Maria.Lankinen@uku.fi
RI Kolehmainen, Marjukka/JFS-1563-2023; Oresic, Matej/K-7673-2016;
   Peddinti, Gopal/G-4872-2016
OI Lankinen, Maria/0000-0002-9158-283X; Oresic, Matej/0000-0002-2856-9165;
   Peddinti, Gopal/0000-0002-8767-968X; Kolehmainen,
   Marjukka/0000-0002-3770-2538
FU Fazer bakeries Ltd; Vaasan Et Vaasan oy; Technology Development Center
   of Finland; Academy of Finland [117996, 209445, 210449]; Sigrid Juselius
   Foundation; Academy of Finland (AKA) [210449, 209445, 117996] Funding
   Source: Academy of Finland (AKA)
FX Sources of Support for research: This work was supported by Fazer
   bakeries Ltd, Vaasan Et Vaasan oy, and the Technology Development Center
   of Finland and the Academy of Finland (no 117996 to MO, no 209445 to MK,
   no 210449 to HG), and the Sigrid Juselius Foundation.
CR Aiyar N, 2007, MOL CELL BIOCHEM, V295, P113, DOI 10.1007/s11010-006-9280-x
   Ajani UA, 2004, J NUTR, V134, P1181, DOI 10.1093/jn/134.5.1181
   Andersson A, 2007, J NUTR, V137, P1401, DOI 10.1093/jn/137.6.1401
   [Anonymous], 2007, R: A language and environment for statistical computing
   BIRGHAM SA, 1988, MANUAL METHODOLOGY F
   *DEP NUTR NAT PUBL, 2003, PUBL NAT PUBL HLTH I
   Erkkilä A, 2008, PROG LIPID RES, V47, P172, DOI 10.1016/j.plipres.2008.01.004
   Fernandez-Quintela A, 2007, PUBLIC HEALTH NUTR, V10, P1126, DOI 10.1017/S1368980007000602
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Gauthier B, 1999, ATHEROSCLEROSIS, V142, P301, DOI 10.1016/S0021-9150(98)00245-7
   Gibney MJ, 2005, AM J CLIN NUTR, V82, P497, DOI 10.1093/ajcn/82.3.497
   Huang YH, 1999, CLIN EXP IMMUNOL, V116, P326
   Jang Y, 2001, ARTERIOSCL THROM VAS, V21, P2065, DOI 10.1161/hq1201.100258
   Juntunen KS, 2003, AM J CLIN NUTR, V77, P385
   Kallio P, 2008, AM J CLIN NUTR, V87, P1497, DOI 10.1093/ajcn/87.5.1497
   Kallio P, 2007, AM J CLIN NUTR, V85, P1417, DOI 10.1093/ajcn/85.5.1417
   Katajamaa M, 2006, BIOINFORMATICS, V22, P634, DOI 10.1093/bioinformatics/btk039
   Laaksonen DE, 2004, ANN MED, V36, P332, DOI 10.1080/07853890410031849
   Laaksonen DE, 2005, AM J CLIN NUTR, V82, P1218, DOI 10.1093/ajcn/82.6.1218
   Liese AD, 2003, AM J CLIN NUTR, V78, P965, DOI 10.1093/ajcn/78.5.965
   Michalska A, 2007, J AGR FOOD CHEM, V55, P734, DOI 10.1021/jf062425w
   Oresic M, 2006, EXPERT REV MOL DIAGN, V6, P575, DOI 10.1586/14737159.6.4.575
   Pietiläinen KH, 2008, PLOS MED, V5, DOI 10.1371/journal.pmed.0050051
   Qi L, 2006, DIABETES CARE, V29, P207, DOI 10.2337/diacare.29.02.06.dc05-1903
   Schwab U, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002630
   Seal CJ, 2006, P NUTR SOC, V65, P24, DOI 10.1079/PNS2005482
   Smith SC, 2007, AM J MED, V120, pS3, DOI 10.1016/j.amjmed.2007.01.002
   Storey JD, 2002, J ROY STAT SOC B, V64, P479, DOI 10.1111/1467-9868.00346
   Storey JD, 2003, P NATL ACAD SCI USA, V100, P9440, DOI 10.1073/pnas.1530509100
   Subramanian A, 2005, P NATL ACAD SCI USA, V102, P15545, DOI 10.1073/pnas.0506580102
   Wenk MR, 2005, NAT REV DRUG DISCOV, V4, P594, DOI 10.1038/nrd1776
   WOLD S, 1987, CHEMOMETR INTELL LAB, V2, P37, DOI 10.1016/0169-7439(87)80084-9
   Wymann MP, 2008, NAT REV MOL CELL BIO, V9, P162, DOI 10.1038/nrm2335
   Zou H, 2005, J R STAT SOC B, V67, P301, DOI 10.1111/j.1467-9868.2005.00503.x
NR 34
TC 40
Z9 44
U1 0
U2 35
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD MAY
PY 2010
VL 20
IS 4
BP 249
EP 257
DI 10.1016/j.numecd.2009.04.009
PG 9
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 612IU
UT WOS:000278891900005
PM 19553094
DA 2025-06-11
ER

PT J
AU Hupa-Breier, KL
   Schenk, H
   Campos-Murguia, A
   Wellhöner, F
   Heidrich, B
   Dywicki, J
   Hartleben, B
   Böker, C
   Mall, J
   Terkamp, C
   Wilkens, L
   Becker, F
   Rudolph, KL
   Manns, MP
   Mederacke, YS
   Marhenke, S
   Redeker, H
   Lieber, M
   Iordanidis, K
   Taubert, R
   Wedemeyer, H
   Noyan, F
   Hardtke-Wolenski, M
   Jaeckel, E
AF Hupa-Breier, Katharina L.
   Schenk, Heiko
   Campos-Murguia, Alejandro
   Wellhoener, Freya
   Heidrich, Benjamin
   Dywicki, Janine
   Hartleben, Bjoern
   Boeker, Clara
   Mall, Julian
   Terkamp, Christoph
   Wilkens, Ludwig
   Becker, Friedrich
   Rudolph, Karl Lenhard
   Manns, Michael Peter
   Mederacke, Young-Seon
   Marhenke, Silke
   Redeker, Hanna
   Lieber, Maren
   Iordanidis, Konstantinos
   Taubert, Richard
   Wedemeyer, Heiner
   Noyan, Fatih
   Hardtke-Wolenski, Matthias
   Jaeckel, Elmar
TI Novel translational mouse models of metabolic dysfunction-associated
   steatotic liver disease comparable to human MASLD with severe obesity
SO MOLECULAR METABOLISM
LA English
DT Article
DE Metabolic dysfunction-associated steatotic liver disease; Metabolic
   syndrome; Mouse model; Kidney injury; Non-alcoholic fatty liver disease
ID NONALCOHOLIC FATTY LIVER; INSULIN SENSITIVITY; GUT MICROBIOME; KIDNEY
   INJURY; GENE; PATHOGENESIS; INFLAMMATION; CIRRHOSIS; SYSTEM; NAFLD
AB Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common cause of chronic liver disease, especially in patients with severe obesity. However, current mouse models for MASLD do not reflect the polygenetic background nor the metabolic changes in this population. Therefore, we investigated two novel mouse models of MASLD with a polygenetic background for the metabolic syndrome. Methods: TALLYHO/JngJ mice and NONcNZO10/LtJ mice were fed a high-fat- high-carbohydrate (HF-HC) diet with a surplus of cholesterol diet. A second group of TH mice was additional treated with empagliflozin. Results: After sixteen weeks of feeding, both strains developed metabolic syndrome with severe obesity and histological manifestation of steatohepatitis, which was associated with significantly increased intrahepatic CD8+cells, CD4+cells and Tregs, contributing to a significant increase in pro-inflammatory and pro-fibrotic gene activation as well as ER stress and oxidative stress. In comparison with the human transcriptomic signature, we could demonstrate a good metabolic similarity, especially for the TH mouse model. Furthermore, TH mice also developed signs of kidney injury as an extrahepatic comorbidity of MASLD. Additional treatment with empagliflozin in TH mice attenuates hepatic steatosis and improves histological manifestation of MASH. Conclusions: Overall, we have developed two promising new mouse models that are suitable for preclinical studies of MASLD as they recapitulate most of the key features of MASLD. (c) 2025 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Hupa-Breier, Katharina L.; Campos-Murguia, Alejandro; Wellhoener, Freya; Heidrich, Benjamin; Dywicki, Janine; Terkamp, Christoph; Manns, Michael Peter; Mederacke, Young-Seon; Marhenke, Silke; Redeker, Hanna; Lieber, Maren; Iordanidis, Konstantinos; Taubert, Richard; Wedemeyer, Heiner; Noyan, Fatih; Hardtke-Wolenski, Matthias; Jaeckel, Elmar] Hannover Med Sch, Dept Gastroenterol Hepatol Infect Dis & Endocrinol, Carl Neuberg Str 1, D-30625 Hannover, Germany.
   [Schenk, Heiko] Hannover Med Sch, Dept Nephrol & Hypertens, Hannover, Germany.
   [Hartleben, Bjoern] Hannover Med Sch, Inst Pathol, Hannover, Germany.
   [Becker, Friedrich; Rudolph, Karl Lenhard] Leibniz Inst Aging, Fritz Lipmann Inst FLI, Res Grp Stem Cell & Metab Aging, D-07745 Jena, Germany.
   [Boeker, Clara; Mall, Julian] Klinikum Nordstadt, Dept Gen Visceral Vasc & Bariatr Surg, D-30167 Hannover, Germany.
   [Wilkens, Ludwig] Nordstadt Hosp Hannover, Dept Pathol, D-30167 Hannover, Germany.
   [Hardtke-Wolenski, Matthias] Univ Duisburg Essen, Univ Hosp Essen, Inst Med Microbiol, Essen, Germany.
   [Jaeckel, Elmar] Univ Toronto, United Hlth Network, Toronto Gen Hosp, Ajmera Transplant Ctr, Toronto, ON, Canada.
C3 Hannover Medical School; Hannover Medical School; Hannover Medical
   School; Leibniz Association; Leibniz Institut fur Alternsforschung -
   Fritz-Lipmann-Institut (FLI); University of Duisburg Essen; University
   of Toronto; University Health Network Toronto; Toronto General Hospital
RP Hupa-Breier, KL (corresponding author), Hannover Med Sch, Dept Gastroenterol Hepatol Infect Dis & Endocrinol, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM hupa.katharina@mh-hannover.de
RI Manns, Michael/AFG-3063-2022; Noyan, Fatih/B-9449-2018;
   Hardtke-Wolenski, Matthias/I-2993-2019
OI Hardtke-Wolenski, Matthias/0000-0002-2827-7787
FU Deutsche Forschungsgemeinschaft [SFB 738, SFB TR127]; HiLF program
   (Hochschulinterne Leistungsforderung) of Hannover Medical School;
   PRACTIS - Clinician Scientist Program of Hannover Medical School [ME
   3696/3-1]; German Research Foundation (DFG) [ME 3696/3-1]
FX The authors were supported by grants from the Deutsche
   Forschungsgemeinschaft (SFB 738, SFB TR127) as well as by the HiLF
   program (Hochschulinterne Leistungsforderung) of Hannover Medical
   School. Katharina Hupa-Breier and Heiko Schenk were supported by the
   PRACTIS - Clinician Scientist Program of Hannover Medical School, funded
   by the German Research Foundation (DFG, ME 3696/3-1). The funders had no
   influence on study design, data collection and analysis, decision to
   publish or preparation of the manuscript.
CR Adare A, 2009, PHYS REV LETT, V103, DOI 10.1103/PhysRevLett.103.012003
   Al-Humadi H, 2012, DIGEST DIS SCI, V57, P3168, DOI 10.1007/s10620-012-2299-9
   Androutsakos T, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23063107
   Asgharpour A, 2016, J HEPATOL, V65, P579, DOI 10.1016/j.jhep.2016.05.005
   Bedi O, 2019, J CLIN EXP HEPATOL, V9, P607, DOI 10.1016/j.jceh.2018.10.004
   Bissig-Choisat B, 2021, JHEP REP, V3, DOI 10.1016/j.jhepr.2021.100281
   Brown E, 2021, LANCET, V398, P262, DOI 10.1016/S0140-6736(21)00536-5
   Brown GT, 2016, METABOLISM, V65, P1080, DOI 10.1016/j.metabol.2015.11.008
   Byrne CD, 2020, J HEPATOL, V72, P785, DOI 10.1016/j.jhep.2020.01.013
   Cheung KS, 2024, HEPATOLOGY, V80, P916, DOI 10.1097/HEP.0000000000000855
   Cho YR, 2007, AM J PHYSIOL-ENDOC M, V293, pE327, DOI 10.1152/ajpendo.00376.2006
   Coilly A, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-56235-y
   Colosimo S, 2023, NUTR METAB CARDIOVAS, V33, P640, DOI 10.1016/j.numecd.2022.12.010
   Dai X, 2024, FRONT BIOSCI-LANDMRK, V29, DOI 10.31083/j.fbl2902062
   DeFronzo RA, 2017, DIABETES OBES METAB, V19, P1353, DOI 10.1111/dom.12982
   DeFronzo RA, 2017, NAT REV NEPHROL, V13, P11, DOI 10.1038/nrneph.2016.170
   Deji N, 2009, AM J PHYSIOL-RENAL, V296, pF118, DOI 10.1152/ajprenal.00110.2008
   Del Chierico F, 2017, HEPATOLOGY, V65, P451, DOI 10.1002/hep.28572
   Deng CJ, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms232012376
   Denvir J, 2016, BMC GENOMICS, V17, DOI 10.1186/s12864-016-3245-6
   Dudek M, 2021, NATURE, V592, DOI 10.1038/s41586-021-03233-8
   Endig J, 2016, CANCER CELL, V30, P308, DOI 10.1016/j.ccell.2016.06.009
   Eslam M, 2020, GASTROENTEROLOGY, V158, P1999, DOI 10.1053/j.gastro.2019.11.312
   Miquilena-Colina ME, 2011, GUT, V60, P1394, DOI 10.1136/gut.2010.222844
   Farrell G, 2019, HEPATOLOGY, V69, P2241, DOI 10.1002/hep.30333
   Fede G, 2012, J HEPATOL, V56, P810, DOI 10.1016/j.jhep.2011.10.016
   Franko A, 2017, MOL METAB, V6, P256, DOI 10.1016/j.molmet.2016.12.007
   Geidl-Flueck B, 2023, J ENDOCRINOL, V257, DOI 10.1530/JOE-22-0270
   Giles DA, 2017, NAT MED, V23, P829, DOI 10.1038/nm.4346
   Gómez-Zorita S, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092156
   Hagstrom Hannes, 2024, Lancet Gastroenterol Hepatol, V9, P944, DOI 10.1016/S2468-1253(24)00193-6
   Hagström H, 2018, GUT, V67, P1536, DOI 10.1136/gutjnl-2016-313622
   Hardtke-Wolenski M, 2013, HEPATOLOGY, V58, P718, DOI 10.1002/hep.26380
   Harrison SA, 2023, NAT MED, V29, DOI 10.1038/s41591-023-02603-1
   Hebbard L, 2011, NAT REV GASTRO HEPAT, V8, P34, DOI 10.1038/nrgastro.2010.191
   Heidrich B, 2018, LIVER INT, V38, P50, DOI 10.1111/liv.13485
   Huebbe P, 2024, AGING DIS, V15, P259, DOI 10.14336/AD.2023.0530
   Hupa-Breier KL, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9040353
   Ibrahim SH, 2016, DIGEST DIS SCI, V61, P1325, DOI 10.1007/s10620-015-3977-1
   Im YR, 2021, HEPATOLOGY, V74, P1884, DOI 10.1002/hep.31897
   Kahl S, 2020, DIABETES CARE, V43, P298, DOI 10.2337/dc19-0641
   Kanehisa M, 2016, NUCLEIC ACIDS RES, V44, pD457, DOI 10.1093/nar/gkv1070
   Kanwar P, 2016, CLIN LIVER DIS, V20, P225, DOI 10.1016/j.cld.2015.10.002
   Kashani K, 2017, CLIN CHEM LAB MED, V55, P1074, DOI 10.1515/cclm-2016-0973
   Kawaguchi T, 2024, J GASTROENTEROL, V59, P836, DOI 10.1007/s00535-024-02122-x
   Kelly KJ, 2015, AM J NEPHROL, V41, P48, DOI 10.1159/000371426
   Kendall TJ, 2023, NAT MED, V29, DOI 10.1038/s41591-023-02602-2
   Kim JH, 2005, PHYSIOL GENOMICS, V22, P171, DOI 10.1152/physiolgenomics.00197.2004
   Kim Jung Han, 2012, Methods Mol Biol, V933, P75, DOI 10.1007/978-1-62703-068-7_6
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Koliaki C, 2015, CELL METAB, V21, P739, DOI 10.1016/j.cmet.2015.04.004
   Krenkel O, 2018, HEPATOLOGY, V67, P1270, DOI 10.1002/hep.29544
   Kuchay MS, 2018, DIABETES CARE, V41, P1801, DOI 10.2337/dc18-0165
   Lee Y, 2019, CLIN GASTROENTEROL H, V17, P1040, DOI 10.1016/j.cgh.2018.10.017
   Lei YT, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.01223
   Li YY, 2023, LIVER INT, V43, P1170, DOI 10.1111/liv.15571
   Liu WH, 2024, CELL METAB, V36, DOI 10.1016/j.cmet.2024.08.005
   Loomba R, 2023, LANCET GASTROENTEROL, V8, P511, DOI 10.1016/S2468-1253(23)00068-7
   Loomba R, 2017, CELL METAB, V25, P1054, DOI 10.1016/j.cmet.2017.04.001
   Ma C, 2016, NATURE, V531, P253, DOI 10.1038/nature16969
   Machado MV, 2016, GASTROENTEROLOGY, V150, P1769, DOI 10.1053/j.gastro.2016.02.066
   Mao XH, 2024, GUT, V73, P2054, DOI 10.1136/gutjnl-2024-332481
   Marakala V, 2022, CLIN CHIM ACTA, V536, P135, DOI 10.1016/j.cca.2022.08.029
   Marin RD, 2019, METHODSX, V6, P918, DOI 10.1016/j.mex.2019.04.010
   Meijnikman AS, 2025, J HEPATOL, V82, P760, DOI 10.1016/j.jhep.2024.11.025
   Mezzano S, 2004, NEPHROL DIAL TRANSPL, V19, P2505, DOI 10.1093/ndt/gfh207
   Moreno-Vedia J, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10010197
   Nagaya T, 2010, J HEPATOL, V53, P724, DOI 10.1016/j.jhep.2010.04.033
   Najt CP, 2016, AM J PHYSIOL-GASTR L, V310, pG726, DOI 10.1152/ajpgi.00436.2015
   Nati M, 2016, REV ENDOCR METAB DIS, V17, P29, DOI 10.1007/s11154-016-9339-2
   Navarro-González JF, 2008, J AM SOC NEPHROL, V19, P433, DOI 10.1681/ASN.2007091048
   Lopez AMCO, 2024, SCI REP-UK, V14, DOI 10.1038/s41598-024-52603-5
   Quesada-Vázquez S, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9010176
   Rada P, 2020, CELL DEATH DIS, V11, DOI 10.1038/s41419-020-03003-w
   Rahman K, 2017, J CLIN INVEST, V127, P2904, DOI 10.1172/JCI75005
   Rau M, 2016, J IMMUNOL, V196, P97, DOI 10.4049/jimmunol.1501175
   Raverdy V, 2024, METABOLISM, V153, DOI 10.1016/j.metabol.2024.155790
   Riazi K, 2022, LANCET GASTROENTEROL, V7, P851, DOI 10.1016/S2468-1253(22)00165-0
   Rinella ME, 2023, J HEPATOL, V79, P1542, DOI 10.1016/j.jhep.2023.06.003
   Riordan JD, 2014, MAMM GENOME, V25, P473, DOI 10.1007/s00335-014-9521-3
   Safari Z, 2019, CELL MOL LIFE SCI, V76, P1541, DOI 10.1007/s00018-019-03011-w
   Saxena R, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0268260
   Schindelin J, 2012, NAT METHODS, V9, P676, DOI [10.1038/NMETH.2019, 10.1038/nmeth.2019]
   Shen TH, 2024, DIABETES OBES METAB, V26, P5116, DOI 10.1111/dom.15853
   Shin SK, 2018, PFLUG ARCH EUR J PHY, V470, P1721, DOI 10.1007/s00424-018-2195-z
   Sun DQ, 2021, METABOLISM, V115, DOI 10.1016/j.metabol.2020.154433
   Sutti S, 2020, NAT REV GASTRO HEPAT, V17, P81, DOI 10.1038/s41575-019-0210-2
   Tacke F, 2022, Z GASTROENTEROL, V60, P733, DOI DOI 10.1055/a-1880-2388
   Teufel A, 2016, GASTROENTEROLOGY, V151, P513, DOI 10.1053/j.gastro.2016.05.051
   Tilg H, 2016, GUT, V65, P2035, DOI 10.1136/gutjnl-2016-312729
   Tozzi M, 2024, DIABETES, V73, DOI 10.2337/db24-1642-P
   Tsai KF, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10081166
   Tsai TH, 2017, AUTOPHAGY, V13, P1130, DOI 10.1080/15548627.2017.1319544
   Tsouka S, 2024, COMMUN MED-LONDON, V4, DOI 10.1038/s43856-024-00465-3
   Vacca M, 2024, NAT METAB, V6, P1178, DOI 10.1038/s42255-024-01043-6
   Vairetti M, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10030364
   Vonderlin J, 2023, CELL MOL GASTROENTER, V15, P1311, DOI 10.1016/j.jcmgh.2023.03.002
   Wang H, 2021, J HEPATOL, V75, P1271, DOI 10.1016/j.jhep.2021.07.032
   Wang QL, 2021, J CLIN TRANSL HEPATO, V9, P90, DOI 10.14218/JCTH.2020.00104
   Wang YY, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11050799
   Wen YM, 2021, CRIT REV CL LAB SCI, V58, P354, DOI 10.1080/10408363.2021.1879000
   Wilson CG, 2016, ENDOCRINOLOGY, V157, P570, DOI 10.1210/en.2015-1866
   Younossi ZM, 2025, CLIN MOL HEPATOL, V31, DOI 10.3350/cmh.2024.0431
NR 103
TC 0
Z9 0
U1 3
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-8778
J9 MOL METAB
JI Mol. Metab.
PD MAR
PY 2025
VL 93
AR 102104
DI 10.1016/j.molmet.2025.102104
EA JAN 2025
PG 18
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA U9I4Z
UT WOS:001414839800001
PM 39855563
OA gold
DA 2025-06-11
ER

PT J
AU Tomassoni, D
   Nwankwo, IE
   Gabrielli, MG
   Bhatt, S
   Muhammad, AB
   Lokhandwala, MF
   Tayebati, SK
   Amenta, F
AF Tomassoni, Daniele
   Nwankwo, Innocent Ejike
   Gabrielli, Maria Gabriella
   Bhatt, Siddhartha
   Muhammad, Abdul Bari
   Lokhandwala, Mustafa F.
   Tayebati, Seyed Khosrow
   Amenta, Francesco
TI Astrogliosis in the brain of obese Zucker rat: A model of metabolic
   syndrome
SO NEUROSCIENCE LETTERS
LA English
DT Article
DE Metabolic syndrome; Obese Zucker rats; Brain; Astrogliosis
ID FIBRILLARY ACIDIC PROTEIN; SPONTANEOUSLY HYPERTENSIVE-RATS;
   ALZHEIMERS-DISEASE; OXIDATIVE STRESS; RISK-FACTORS; ASTROCYTES;
   DEMENTIA; GFAP; HIPPOCAMPUS; EXPRESSION
AB Metabolic syndrome (MetS) is a disorder characterized primarily by the development of insulin resistance. Insulin resistance and subsequent hyperinsulinemia, originating from abdominal obesity, increases the risk of cerebrovascular and cardiovascular disease and all-cause mortality. Obesity is probably a risk factor for Alzheimer's disease and vascular dementia and is associated with impaired cognitive function. The obese Zucker rat (OZR) represents a model of type 2 diabetes exhibiting a moderate degree of arterial hypertension and of increased oxidative stress. To clarify the possible relationships between MetS and brain damage, the present study has investigated brain microanatomy in OZRs compared with their littermate controls lean Zucker rats (LZRs). Male OZRs and LZRs of 12 weeks of age were used. Their brain was processed for immunochemical and immunohistochemical analysis of glial fibrillaiy acidic protein (GFAP). In frontal and parietal cortex of OZRs a significant increase in the number of GFAP immunoreactive astrocytes was observed. Similar findings were found in the hippocampus, where an increased number of GFAP immunoreactive astrocytes were detected in the CA1 and CA3 subfields and dentate gyrus of OZRs compared to the LZRs. These findings indicating the occurrence of brain injury accompanied by astrogliosis in OZRs suggest that these rats, developed as an animal model of type 2 diabetes, may also represent a model for assessing the influence of MetS on brain. The identification of neurodegenerative changes in OZRs may represent the first step for better characterizing neuronal involvement in this model of MetS and possible treatment for countering it. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
C1 [Tomassoni, Daniele; Gabrielli, Maria Gabriella] Univ Camerino, Sch Biosci & Biotechnol, I-62032 Camerino, MC, Italy.
   [Nwankwo, Innocent Ejike; Tayebati, Seyed Khosrow; Amenta, Francesco] Univ Camerino, Sch Med & Hlth Prod, I-62032 Camerino, Italy.
   [Bhatt, Siddhartha; Muhammad, Abdul Bari; Lokhandwala, Mustafa F.] Univ Houston, Coll Pharm, Heart & Kidney Inst, Houston, TX 77204 USA.
C3 University of Camerino; University of Camerino; University of Houston
   System; University of Houston
RP Tomassoni, D (corresponding author), Univ Camerino, Sch Biosci & Biotechnol, Via Gentile 3 Varano, I-62032 Camerino, MC, Italy.
EM daniele.tomassoni@unicam.it
RI Tayebati, Seyed/AGK-8739-2022
OI NWANKWO, EJIKE/0000-0002-1166-9709
CR de Artiñano AA, 2009, BRIT J NUTR, V102, P1246, DOI 10.1017/S0007114509990729
   Bates KA, 2007, NEUROBIOL AGING, V28, P995, DOI 10.1016/j.neurobiolaging.2006.05.003
   BEACH TG, 1989, GLIA, V2, P420, DOI 10.1002/glia.440020605
   Bignami A., 1980, ADV CELL NEUROBIOL, V1, P285, DOI 10.1016/B978-0-12-008301-5.50012-1
   Bond CE, 2007, GLIA, V55, P1348, DOI 10.1002/glia.20547
   Catalani A, 2002, MECH AGEING DEV, V123, P481, DOI 10.1016/S0047-6374(01)00356-6
   Cheung WM, 1999, CHINESE J PHYSIOL, V42, P227
   Czlonkowska A, 2011, J NEUROIMMUNOL, V231, P78, DOI 10.1016/j.jneuroim.2010.09.020
   Etgen T, 2011, DTSCH ARZTEBL INT, V108, P743, DOI 10.3238/arztebl.2011.0743
   Gazdzinski S, 2008, ANN NEUROL, V63, P652, DOI 10.1002/ana.21377
   Grundy SM, 2007, J CLIN ENDOCR METAB, V92, P399, DOI 10.1210/jc.2006-0513
   HATTEN ME, 1991, GLIA, V4, P233, DOI 10.1002/glia.440040215
   LATOV N, 1979, DEV BIOL, V72, P381, DOI 10.1016/0012-1606(79)90127-1
   LINNEMANN D, 1994, NEUROBIOL AGING, V15, P651, DOI 10.1016/0197-4580(94)00060-3
   Lusis AJ, 2008, NAT REV GENET, V9, P819, DOI 10.1038/nrg2468
   Malhotra S.K., 2001, NEUROGLIA AGING BRAI, P27
   Michikawa M, 2003, J NEUROSCI RES, V72, P141, DOI 10.1002/jnr.10585
   Milionis HJ, 2008, CNS SPECTRUMS, V13, P606, DOI 10.1017/S1092852900016886
   NICHOLS NR, 1993, NEUROBIOL AGING, V14, P421, DOI 10.1016/0197-4580(93)90100-P
   Osmond JM, 2009, HYPERTENSION, V53, P381, DOI 10.1161/HYPERTENSIONAHA.108.124149
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Sabbatini M, 2002, MECH AGEING DEV, V123, P547, DOI 10.1016/S0047-6374(01)00362-1
   Sickmann HM, 2010, J CEREBR BLOOD F MET, V30, P1527, DOI 10.1038/jcbfm.2010.61
   Sofroniew MV, 2005, NEUROSCIENTIST, V11, P400, DOI 10.1177/1073858405278321
   Stapleton Phoebe A, 2008, Pathophysiology, V15, P79, DOI 10.1016/j.pathophys.2008.04.007
   TAKAMIYA Y, 1988, DEV BRAIN RES, V38, P201, DOI 10.1016/0165-3806(88)90045-4
   Tomassoni D, 2004, CLIN EXP HYPERTENS, V26, P305, DOI 10.1081/CEH-120034136
   Tomassoni D, 2004, CLIN EXP HYPERTENS, V26, P335, DOI 10.1081/CEH-120034138
   Unger JW, 1998, MICROSC RES TECHNIQ, V43, P24, DOI 10.1002/(SICI)1097-0029(19981001)43:1<24::AID-JEMT4>3.0.CO;2-P
   Whitmer RA, 2005, NEUROLOGY, V64, P277, DOI 10.1212/01.WNL.0000149519.47454.F2
NR 30
TC 48
Z9 53
U1 0
U2 11
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0304-3940
EI 1872-7972
J9 NEUROSCI LETT
JI Neurosci. Lett.
PD MAY 24
PY 2013
VL 543
BP 136
EP 141
DI 10.1016/j.neulet.2013.03.025
PG 6
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 154BH
UT WOS:000319646000027
PM 23545209
DA 2025-06-11
ER

PT J
AU Cat, AND
   Jaisser, F
AF Cat, Aurelie Nguyen Dinh
   Jaisser, Frederic
TI Extrarenal effects of aldosterone
SO CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
LA English
DT Review
DE aldosterone; fibrogenic and proinflammatory effects; metabolic syndrome;
   mineralocorticoid receptor; receptor tyrosine kinases
ID VASCULAR SMOOTH-MUSCLE; PERIVASCULAR ADIPOSE-TISSUE; SPONTANEOUSLY
   HYPERTENSIVE-RATS; NITRIC-OXIDE SYNTHASE; MINERALOCORTICOID RECEPTOR
   EXPRESSION; INDUCED CARDIAC FIBROSIS; NF-KAPPA-B; ANGIOTENSIN-II;
   OXIDATIVE STRESS; INSULIN-RESISTANCE
AB Purpose of review
   The renal distal tubule has been considered for a long time as the main cellular target of aldosterone, where the hormone enhances sodium reabsorption and potassium secretion. However, other cell types in nonepithelial tissues, such as the heart, the vessels, adipose tissue, and macrophages, are now also recognized as targets for aldosterone. The functions that aldosterone exerts in these nonclassical target tissues are still a matter of debate. This review will highlight the recent findings on the extrarenal effects of aldosterone.
   Recent findings
   Numerous studies showed that aldosterone exerts profibrotic and proinflammatory effects, but one or more cofactors such as salt, angiotensin II, and oxidative stress are required. Moreover, inflammation and macrophage infiltration are a prerequisite to aldosterone-induced cardiac fibrosis. This underlines a key role for aldosterone and the mineralocorticoid receptor in macrophages. Inflammatory effects of aldosterone in vascular smooth muscle cells involve trafficking to lipid rafts/caveolae through receptor tyrosine kinases. Finally, a growing body of evidence indicates a prominent role of aldosterone/mineralocorticoid receptor in the metabolic syndrome, in insulin resistance, and in adipocyte biology.
   Summary
   The idiom from Socrates, 'the more we learn, the less we know', can be applied to aldosterone with its different facets and its pleiotropic effects. There is clear evidence for rapid nongenomic effects of aldosterone, mineralocorticoid receptor-dependent and mineralocorticoid receptor-independent signaling, in the heart, the vessels, and other nonepithelial tissues, leading to inflammation, fibrosis, and progression of cardiovascular diseases including hypertension and metabolic syndrome.
C1 [Cat, Aurelie Nguyen Dinh] Univ Ottawa, Kidney Res Ctr, Ottawa Hosp, Res Inst, Ottawa, ON K1H 8M5, Canada.
   [Jaisser, Frederic] Univ Paris 06, INSERM, Ctr Rech Cordeliers, UMR Team 1 872, Paris, France.
C3 University of Ottawa; Ottawa Hospital Research Institute; Sorbonne
   Universite; Universite Paris Cite; Institut National de la Sante et de
   la Recherche Medicale (Inserm)
RP Cat, AND (corresponding author), Univ Ottawa, Kidney Res Ctr, Ottawa Hosp, Res Inst, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada.
EM cattuong.ndc@gmail.com
RI CAT, Aurelie/H-8182-2013; Jaisser, Frederic/P-4287-2017
OI Jaisser, Frederic/0000-0001-9051-1901
FU Canadian Institute of Health Research (CIHR); INSERM; Leducq foundation;
   Transatlantic Network on Hypertension
FX A.N.D.C. is supported by the Canadian Institute of Health Research
   (CIHR). Grants from INSERM, the Leducq foundation and Transatlantic
   Network on Hypertension supported this work.
CR Ambroisine ML, 2007, CIRCULATION, V116, P2435, DOI 10.1161/CIRCULATIONAHA.107.722009
   Aurelie NDC, 2011, HYPERTENSION, V58, P479, DOI 10.1161/HYPERTENSIONAHA.110.168872
   Balfagón G, 2004, REGUL PEPTIDES, V120, P253, DOI 10.1016/j.regpep.2004.03.016
   Bertocchio JP, 2011, KIDNEY INT, V79, P1051, DOI 10.1038/ki.2011.48
   Boldyreff B, 2003, NEPHROL DIAL TRANSPL, V18, P1693, DOI 10.1093/ndt/gfg265
   Brandes RP, 2007, BRIT J PHARMACOL, V151, P303, DOI 10.1038/sj.bjp.0707229
   Briet M, 2011, CURR HYPERTENS REP, V13, P163, DOI 10.1007/s11906-011-0182-2
   BRILLA CG, 1993, J MOL CELL CARDIOL, V25, P563, DOI 10.1006/jmcc.1993.1066
   BRILLA CG, 1990, CIRC RES, V67, P1355, DOI 10.1161/01.RES.67.6.1355
   Brücher R, 2007, OBESITY, V15, P1643, DOI 10.1038/oby.2007.196
   Callera GE, 2005, HYPERTENSION, V46, P1032, DOI 10.1161/01.HYP.0000176588.51027.35
   Callera GE, 2005, HYPERTENSION, V45, P773, DOI 10.1161/01.HYP.0000154365.30593.d3
   Callera GE, 2011, CARDIOVASC RES, V91, P720, DOI 10.1093/cvr/cvr131
   Caprio M, 2007, FASEB J, V21, P2185, DOI 10.1096/fj.06-7970com
   Caprio M, 2011, ENDOCRINOLOGY, V152, P113, DOI 10.1210/en.2010-0674
   Cat AND, 2010, FASEB J, V24, P2454, DOI 10.1096/fj.09-147926
   Chansel D, 2006, FASEB J, V20, P1936, DOI 10.1096/fj.05-5328fje
   Christ M, 1999, CIRCULATION, V99, P1485, DOI 10.1161/01.CIR.99.11.1485
   CHRIST M, 1995, BIOCHEM BIOPH RES CO, V213, P123, DOI 10.1006/bbrc.1995.2106
   Dartsch T, 2013, INT J CARDIOL, V164, P170, DOI 10.1016/j.ijcard.2011.06.100
   De Mello WC, 2006, J RENIN-ANGIO-ALDO S, V7, P40, DOI 10.3317/jraas.2006.005
   Delano FA, 2004, MICROCIRCULATION, V11, P69, DOI 10.1080/10739680490266207
   Di Zhang A, 2008, HYPERTENSION, V52, P1060, DOI 10.1161/HYPERTENSIONAHA.108.117531
   Dooley R, 2012, MOL CELL ENDOCRINOL, V350, P223, DOI 10.1016/j.mce.2011.07.019
   Dorrance AM, 2009, HYPERTENSION, V54, P451, DOI 10.1161/HYPERTENSIONAHA.109.135855
   Ehrhart-Bornstein M, 2004, ENDOCR RES, V30, P865, DOI 10.1081/ERC-200044122
   Engeli S, 2003, INT J BIOCHEM CELL B, V35, P807, DOI 10.1016/S1357-2725(02)00311-4
   Eringa EC, 2007, MICROCIRCULATION, V14, P389, DOI 10.1080/10739680701303584
   Farman N, 2010, EXP DERMATOL, V19, P100, DOI 10.1111/j.1600-0625.2009.01011.x
   Favre J, 2011, AM J PHYSIOL-HEART C, V300, pH2035, DOI 10.1152/ajpheart.00552.2010
   Feldman RD, 2010, CAN J CARDIOL, V26, p22A, DOI 10.1016/S0828-282X(10)71057-6
   Fels J, 2010, BBA-MOL BASIS DIS, V1802, P1193, DOI 10.1016/j.bbadis.2010.03.006
   Fels J, 2010, PFLUG ARCH EUR J PHY, V460, P915, DOI 10.1007/s00424-010-0871-8
   Fernandes D, 2008, SHOCK, V30, P10, DOI 10.1097/SHK.0b013e3181818518
   Fraccarollo D, 2011, CIRCULATION, V123, P400, DOI 10.1161/CIRCULATIONAHA.110.983023
   Galic S, 2010, MOL CELL ENDOCRINOL, V316, P129, DOI 10.1016/j.mce.2009.08.018
   Galvez B, 2006, ARTERIOSCL THROM VAS, V26, P1297, DOI 10.1161/01.ATV.0000220381.40739.dd
   Garnier A, 2004, CIRCULATION, V110, P1819, DOI 10.1161/01.CIR.0000142858.44680.27
   Gekle M, 1996, P NATL ACAD SCI USA, V93, P10500, DOI 10.1073/pnas.93.19.10500
   Gekle M, 2009, PFLUG ARCH EUR J PHY, V458, P231, DOI 10.1007/s00424-008-0616-0
   Gilbert KC, 2010, CURR OPIN ENDOCRINOL, V17, P199, DOI 10.1097/MED.0b013e3283391989
   Goette A, 2001, AM J CARDIOL, V88, P906, DOI 10.1016/S0002-9149(01)01905-1
   Gómez AM, 2009, CIRCULATION, V119, P2179, DOI 10.1161/CIRCULATIONAHA.108.805804
   Gomez-Sanchez CE, 2011, STEROIDS, V76, P1541, DOI 10.1016/j.steroids.2011.09.004
   Gomez-Sanchez EP, 2011, TRENDS ENDOCRIN MET, V22, P179, DOI 10.1016/j.tem.2011.02.001
   Gorzelniak K, 2002, J HYPERTENS, V20, P965, DOI 10.1097/00004872-200205000-00032
   Griol-Charhbili V, 2011, HYPERTENSION, V57, P238, DOI 10.1161/HYPERTENSIONAHA.110.153619
   Gros R, 2011, HYPERTENSION, V57, P442, DOI 10.1161/HYPERTENSIONAHA.110.161653
   Grossmann C, 2005, MOL ENDOCRINOL, V19, P1697, DOI 10.1210/me.2004-0469
   Grossmann C, 2007, MOL CELL ENDOCRINOL, V277, P6, DOI 10.1016/j.mce.2007.07.001
   Hernández-Díaz I, 2010, ENDOCRINOLOGY, V151, P3888, DOI 10.1210/en.2010-0099
   Holzman JL, 2007, AM J PHYSIOL-RENAL, V292, pF1219, DOI 10.1152/ajprenal.00214.2006
   Hsueh WA, 2011, J CLIN HYPERTENS, V13, P224, DOI 10.1111/j.1751-7176.2011.00449.x
   Jaffe IZ, 2010, J CLIN INVEST, V120, P3891, DOI 10.1172/JCI40205
   Jaisser F, 2011, HYPERTENSION, V57, P679, DOI 10.1161/HYPERTENSIONAHA.110.164962
   Johar S, 2006, FASEB J, V20, P1546, DOI 10.1096/fj.05-4642fje
   Kiyosue A, 2011, HYPERTENS RES, V34, P1283, DOI 10.1038/hr.2011.119
   Kobayashi N, 2006, HYPERTENSION, V47, P671, DOI 10.1161/01.HYP.0000203148.42892.7a
   Kraus D, 2005, HORM METAB RES, V37, P455, DOI 10.1055/s-2005-870240
   Krug AW, 2003, J BIOL CHEM, V278, P43060, DOI 10.1074/jbc.M308134200
   Kusche-Vihrog K, 2011, HYPERTENSION, V57, P231, DOI 10.1161/HYPERTENSIONAHA.110.163444
   Kusche-Vihrog K, 2010, STEROIDS, V75, P544, DOI 10.1016/j.steroids.2009.09.003
   Lalevée N, 2005, CARDIOVASC RES, V67, P216, DOI 10.1016/j.cardiores.2005.05.009
   LARIVIERE R, 1993, HYPERTENSION, V21, P294, DOI 10.1161/01.HYP.21.3.294
   Lastra G, 2010, NAT REV CARDIOL, V7, P577, DOI 10.1038/nrcardio.2010.123
   Le Moëllic C, 2004, J AM SOC NEPHROL, V15, P1145
   Lemarie CA, 2008, J MOL MED, V86, P673, DOI 10.1007/s00109-008-0323-5
   Leopold JA, 2007, NAT MED, V13, P189, DOI 10.1038/nm1545
   Leopold JA, 2009, J CARDIOVASC PHARM, V54, P465, DOI 10.1097/FJC.0b013e3181c37ddc
   Leopold JA, 2009, NAT MED, V15, P1093, DOI 10.1038/nm0909-1093b
   Li RCX, 2000, AM J PHYSIOL-HEART C, V279, pH1679, DOI 10.1152/ajpheart.2000.279.4.H1679
   Liu SL, 2003, CIRCULATION, V108, P2400, DOI 10.1161/01.CIR.0000093188.53554.44
   LOMBES M, 1992, CIRC RES, V71, P503, DOI 10.1161/01.RES.71.3.503
   Lother A, 2011, HYPERTENSION, V57, P746, DOI 10.1161/HYPERTENSIONAHA.110.163287
   Lu H, 2007, AM J PHYSIOL-ENDOC M, V292, pE1280, DOI 10.1152/ajpendo.00277.2006
   Luther JM, 2011, DIABETOLOGIA, V54, P2152, DOI 10.1007/s00125-011-2158-9
   Luther JM, 2011, TRENDS PHARMACOL SCI, V32, P734, DOI 10.1016/j.tips.2011.07.006
   Manegold JC, 1999, CELL MOL BIOL, V45, P805
   Marney AM, 2007, CLIN SCI, V113, P267, DOI 10.1042/CS20070123
   Marzolla V, 2012, MOL CELL ENDOCRINOL, V350, P281, DOI 10.1016/j.mce.2011.09.011
   McCurley A, 2012, MOL CELL ENDOCRINOL, V350, P256, DOI 10.1016/j.mce.2011.06.014
   Mehta VB, 2005, J IMMUNOL, V175, P1911, DOI 10.4049/jimmunol.175.3.1911
   Messaoudi S, 2012, MOL CELL ENDOCRINOL, V350, P266, DOI 10.1016/j.mce.2011.06.038
   Michea L, 2005, ENDOCRINOLOGY, V146, P973, DOI 10.1210/en.2004-1130
   Mihailidou AS, 2006, STEROIDS, V71, P277, DOI 10.1016/j.steroids.2005.09.017
   Milliez P, 2005, J AM COLL CARDIOL, V45, P1243, DOI 10.1016/j.jacc.2005.01.015
   Morello F, 2009, CARDIOVASC RES, V82, P261, DOI 10.1093/cvr/cvn325
   Newfell BG, 2011, ARTERIOSCL THROM VAS, V31, P1871, DOI 10.1161/ATVBAHA.111.229070
   Oberleithner H, 2004, HYPERTENSION, V43, P952, DOI 10.1161/01.HYP.0000123572.45556.a5
   Olivares-Reyes JA, 2009, MOL CELL ENDOCRINOL, V302, P128, DOI 10.1016/j.mce.2008.12.011
   Ouvrard-Pascaud A, 2005, CIRCULATION, V111, P3025, DOI 10.1161/CIRCULATIONAHA.104.503706
   Park JB, 2001, HYPERTENSION, V37, P1444, DOI 10.1161/01.HYP.37.6.1444
   Paul M, 2006, PHYSIOL REV, V86, P747, DOI 10.1152/physrev.00036.2005
   Pérez FR, 2009, HYPERTENSION, V53, P1000, DOI 10.1161/HYPERTENSIONAHA.108.128520
   Perrier R, 2005, J PHYSIOL-LONDON, V569, P153, DOI 10.1113/jphysiol.2005.092692
   Pitt B, 2003, NEW ENGL J MED, V348, P1309, DOI 10.1056/NEJMoa030207
   Pitt B, 1999, NEW ENGL J MED, V341, P709, DOI 10.1056/NEJM199909023411001
   Pu Q, 2003, HYPERTENSION, V42, P49, DOI 10.1161/01.HYP.0000078357.92682.EC
   Qu JX, 2009, CIRC RES, V104, P365, DOI 10.1161/CIRCRESAHA.108.184044
   Reil JC, 2012, EUR HEART J, V33, P2098, DOI 10.1093/eurheartj/ehr266
   Rickard AJ, 2009, HYPERTENSION, V54, P537, DOI 10.1161/HYPERTENSIONAHA.109.131110
   ROBERT V, 1994, HYPERTENSION, V24, P30, DOI 10.1161/01.HYP.24.1.30
   ROBERT V, 1995, HYPERTENSION, V26, P971, DOI 10.1161/01.HYP.26.6.971
   Rocha R, 2002, ENDOCRINOLOGY, V143, P4828, DOI 10.1210/en.2002-220120
   Samuel JL, 2010, NAT REV CARDIOL, V7, P125, DOI 10.1038/nrcardio.2009.244
   Sanz-Rosa D, 2005, ANTIOXID REDOX SIGN, V7, P1294, DOI 10.1089/ars.2005.7.1294
   Sarzani R, 2008, INT J OBESITY, V32, P259, DOI 10.1038/sj.ijo.0803724
   Schiffrin EL, 2006, HYPERTENSION, V47, P312, DOI 10.1161/01.HYP.0000201443.63240.a7
   Silvestre JS, 1998, J BIOL CHEM, V273, P4883, DOI 10.1074/jbc.273.9.4883
   Skott O, 2006, PHARMACOL THERAPEUT, V111, P495, DOI 10.1016/j.pharmthera.2005.10.010
   SOLTIS EE, 1991, CLIN EXP HYPERTENS A, V13, P277, DOI 10.3109/10641969109042063
   Sowers JR, 2007, KIDNEY INT, V71, P719, DOI 10.1038/sj.ki.5002006
   Sowers JR, 2009, ANN INTERN MED, V150, P776, DOI 10.7326/0003-4819-150-11-200906020-00005
   Stas S, 2007, ENDOCRINOLOGY, V148, P3773, DOI 10.1210/en.2006-1691
   Stiefel P, 2011, INT J HYPERTENS, V2011, DOI 10.4061/2011/685238
   Sugiyama T, 2005, ENDOCRINOLOGY, V146, P3900, DOI 10.1210/en.2004-1674
   Sun Y, 2002, AM J PATHOL, V161, P1773, DOI 10.1016/S0002-9440(10)64454-9
   Swynghedauw B, 1999, PHYSIOL REV, V79, P215, DOI 10.1152/physrev.1999.79.1.215
   TAKEDA Y, 1995, HYPERTENSION, V25, P170, DOI 10.1161/01.HYP.25.2.170
   Tasatargil A, 2009, J RENIN-ANGIO-ALDO S, V10, P127, DOI 10.1177/1470320309343655
   Thai HM, 2006, J CARD FAIL, V12, P240, DOI 10.1016/j.cardfail.2006.01.002
   Touyz RM, 2009, CIRC RES, V104, P9, DOI 10.1161/CIRCRESAHA.108.191288
   Tsai CT, 2010, J AM COLL CARDIOL, V55, P758, DOI 10.1016/j.jacc.2009.09.045
   Uhrenholt TR, 2003, CIRC RES, V93, P1258, DOI 10.1161/01.RES.0000106135.02935.E1
   Usher MG, 2010, J CLIN INVEST, V120, P3350, DOI 10.1172/JCI41080
   Viengchareun Say, 2007, Nucl Recept Signal, V5, pe012, DOI 10.1621/nrs.05012
   Virdis A, 2002, HYPERTENSION, V40, P504, DOI 10.1161/01.HYP.0000034738.79310.06
   Virdis A, 2007, CURR PHARM DESIGN, V13, P1693, DOI 10.2174/138161207780831365
   Wada T, 2009, ENDOCRINOLOGY, V150, P1662, DOI 10.1210/en.2008-1018
   WEBER KT, 1993, CARDIOVASC RES, V27, P341, DOI 10.1093/cvr/27.3.341
   WEBER KT, 1989, J AM COLL CARDIOL, V13, P1637, DOI 10.1016/0735-1097(89)90360-4
   WEHLING M, 1994, BIOCHEM BIOPH RES CO, V204, P475, DOI 10.1006/bbrc.1994.2484
   Whaley-Connell A, 2010, PROG CARDIOVASC DIS, V52, P401, DOI 10.1016/j.pcad.2009.12.004
   Withers SB, 2011, ARTERIOSCL THROM VAS, V31, P908, DOI 10.1161/ATVBAHA.110.221705
   Xu J, 2006, HYPERTENSION, V47, pE8, DOI 10.1161/01.HYP.0000200657.31938.8c
   Young M, 2004, ENDOCRINOLOGY, V145, P3153, DOI 10.1210/en.2004-0005
   Young MJ, 2012, MOL CELL ENDOCRINOL, V350, P248, DOI 10.1016/j.mce.2011.09.008
   Zennaro MC, 2009, TRENDS ENDOCRIN MET, V20, P444, DOI 10.1016/j.tem.2009.05.006
   Zhao J, 2010, BRIT J PHARMACOL, V159, P1584, DOI 10.1111/j.1476-5381.2009.00551.x
   Zhao M, 2010, FASEB J, V24, P3405, DOI 10.1096/fj.09-154344
NR 140
TC 85
Z9 85
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1062-4821
EI 1473-6543
J9 CURR OPIN NEPHROL HY
JI Curr. Opin. Nephrol. Hypertens.
PD MAR
PY 2012
VL 21
IS 2
BP 147
EP 156
DI 10.1097/MNH.0b013e32834fb25b
PG 10
WC Urology & Nephrology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology; Cardiovascular System & Cardiology
GA 894DC
UT WOS:000300406200006
PM 22240440
DA 2025-06-11
ER

PT J
AU Kobori, M
   Akimoto, Y
   Takahashi, Y
   Kimura, T
AF Kobori, Masuko
   Akimoto, Yukari
   Takahashi, Yumiko
   Kimura, Toshiyuki
TI Combined Effect of Quercetin and Fish Oil on Oxidative Stress in the
   Liver of Mice Fed a Western-Style Diet
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE quercetin; antioxidant; fish oil; DHA; Western diet; liver; epididymal
   adipose tissue
ID LIPID-PEROXIDATION PRODUCTS; FATTY-ACIDS; CARDIOVASCULAR-DISEASE;
   DOCOSAHEXAENOIC ACID; METABOLIC SYNDROME; ADIPOSE-TISSUE; RISK;
   UNSATURATION; PATHOGENESIS; INFLAMMATION
AB To study the combined effect of the flavonoid quercetin and fish oil containing co-3 fatty acids on preventing diet-induced metabolic syndrome, we fed mice with a control diet, a high-fat, high-sucrose, and high-cholesterol Western-style diet (Western diet), a Western diet supplemented with 0.05% quercetin, a Western diet containing 5% fish oil rich in docosahexaenoic acid (DHA) (DHA diet), or a DHA diet supplemented with 0.05% quercetin. After 18 weeks of feeding, fish oil potentiated the suppression of lipid peroxidation by quercetin in the liver but not in the epididymal adipose tissue. Fish oil but not quercetin suppressed the accumulation of non-esterified fatty acids and the expression of fatty acid synthase in the liver of Western-diet-fed mice. Thus, the combination of quercetin and DHA-rich fish oil may partly alleviate non-alcoholic fatty liver disease by reducing oxidative stress and suppressing fatty acid synthesis.
C1 [Kobori, Masuko; Akimoto, Yukari; Takahashi, Yumiko; Kimura, Toshiyuki] Natl Agr & Food Res Org, Food Res Inst, Tsukuba, Ibaraki 3058642, Japan.
C3 National Agriculture & Food Research Organization - Japan
RP Kobori, M (corresponding author), Natl Agr & Food Res Org, Food Res Inst, Tsukuba, Ibaraki 3058642, Japan.
EM kobori@affrc.go.jp
FU Skylark Food Science Institute; Project of the NARO Bio-oriented
   Technology Research Advancement Institution R&D matching funds on the
   Field for Knowledge Integration and Innovation
FX This work was financially supported in part by grants from the Skylark
   Food Science Institute (to Masuko Kobori) and the Project of the NARO
   Bio-oriented Technology Research Advancement Institution R&D matching
   funds on the Field for Knowledge Integration and Innovation.
CR Adriouch S, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111587
   Ashraf NU, 2015, FREE RADICAL RES, V49, P1405, DOI 10.3109/10715762.2015.1078461
   Clarke SD, 2001, J NUTR, V131, P1129, DOI 10.1093/jn/131.4.1129
   Cobbina E, 2017, DRUG METAB REV, V49, P197, DOI 10.1080/03602532.2017.1293683
   Fabiani R, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092056
   GARG ML, 1988, BIOCHIM BIOPHYS ACTA, V962, P330, DOI 10.1016/0005-2760(88)90262-7
   Heidemann C, 2008, CIRCULATION, V118, P230, DOI 10.1161/CIRCULATIONAHA.108.771881
   Hu CC, 2004, OBES RES, V12, P1264, DOI 10.1038/oby.2004.160
   Huh JY, 2014, MOL CELLS, V37, P365, DOI 10.14348/molcells.2014.0074
   Kobori M, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-27105-w
   Kobori M, 2016, MOL NUTR FOOD RES, V60, P300, DOI 10.1002/mnfr.201500595
   Kobori M, 2011, MOL NUTR FOOD RES, V55, P530, DOI 10.1002/mnfr.201000392
   Liu XM, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201601003
   Martinez J. A., 2013, J PHYSL BIOCH, V69
   Matsuzaka T, 2009, J MOL MED, V87, P379, DOI 10.1007/s00109-009-0449-0
   Mitjavila MT, 1996, LIPIDS, V31, P661, DOI 10.1007/BF02523839
   Moreno JJ, 2003, J NUTR BIOCHEM, V14, P182, DOI 10.1016/S0955-2863(02)00294-2
   Moreno JJ, 2001, J NUTR, V131, P2145, DOI 10.1093/jn/131.8.2145
   Moreno JJ, 2009, J PHARMACOL EXP THER, V331, P1111, DOI 10.1124/jpet.109.157891
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Nishimura S, 2009, NAT MED, V15, P914, DOI 10.1038/nm.1964
   Özogul Y, 2009, INT J FOOD SCI NUTR, V60, P464, DOI [10.1080/09637480701425650, 10.1080/09637480701838175]
   Pereira MA, 2009, INT J ENV RES PUB HE, V6, P2568, DOI 10.3390/ijerph6102568
   Rienks J, 2018, AM J CLIN NUTR, V108, P49, DOI 10.1093/ajcn/nqy083
   Rodríguez-Monforte M, 2017, EUR J NUTR, V56, P925, DOI 10.1007/s00394-016-1305-y
   SAITO M, 1985, Japanese Journal of Nutrition, V43, P301
   Si TL, 2016, MOL MED REP, V14, P499, DOI 10.3892/mmr.2016.5259
   Song JH, 2000, J NUTR, V130, P3028, DOI 10.1093/jn/130.12.3028
   Sun GY, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20040932
   Suzuki-Kemuriyama N, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0157580
   Torris C, 2018, NUTRIENTS, V10, DOI 10.3390/nu10070952
   Tresserra-Rimbau A, 2018, BIOCHEM PHARMACOL, V156, P186, DOI 10.1016/j.bcp.2018.07.050
   Wang HH, 2004, CARDIOVASC RES, V61, P169, DOI 10.1016/j.cardiores.2003.11.002
   Wang X, 2014, BMJ-BRIT MED J, V349, DOI 10.1136/bmj.g4490
   Wang X, 2014, BRIT J NUTR, V111, P1, DOI 10.1017/S000711451300278X
   Wensveen FM, 2015, NAT IMMUNOL, V16, P376, DOI 10.1038/ni.3120
   Wiktorowska-Owczarek A, 2015, ADV CLIN EXP MED, V24, P931, DOI 10.17219/acem/31243
   Xu H, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000010686
   Yamazaki T, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19124107
   Yang JCZ, 2019, NUTRIENTS, V11, DOI 10.3390/nu11040872
   Yoshida Y, 2015, J OLEO SCI, V64, P347, DOI 10.5650/jos.ess14281
NR 41
TC 10
Z9 10
U1 0
U2 35
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD NOV 18
PY 2020
VL 68
IS 46
BP 13267
EP 13275
DI 10.1021/acs.jafc.0c02984
PG 9
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA OW5JM
UT WOS:000592922700053
PM 32786869
DA 2025-06-11
ER

PT J
AU Wan, MX
   Li, Q
   Lei, QY
   Zhou, D
   Wang, S
AF Wan, Meixia
   Li, Qing
   Lei, Qianya
   Zhou, Dan
   Wang, Shu
TI Polyphenols and Polysaccharides from Morus alba L. Fruit
   Attenuate High-Fat Diet-Induced Metabolic Syndrome Modifying the Gut
   Microbiota and Metabolite Profile
SO FOODS
LA English
DT Article
DE Morus alba L. fruit; polyphenols; polysaccharides; metabolic syndrome;
   gut microbiota; untargeted fecal metabolomics
ID INTESTINAL MICROBIOTA; OXIDATIVE STRESS; KIDNEY-DISEASE; MULBERRY;
   ACTIVATION; INFLAMMATION; DYSBIOSIS; NAFLD
AB Morus alba L. fruit, a medicinal and edible fruit in East Asia, showed potential health-promoting effects against metabolic syndrome (MetS). However, both the protective effects and mechanisms of different fractions extracted from Morus alba L. fruit against MetS remain unclear. Additionally, the gut microbiota and its metabolites are regarded as key factors in the development of MetS. This study aimed to investigate the potential role of polyphenols and polysaccharides derived from Morus alba L. fruit against MetS in high-fat diet (HFD)-fed mice, individually and in combination, focusing on remodeling effects on gut microbiota and metabolite profiles. In the study, polyphenols and polysaccharides derived from Morus alba L. fruit improved the traditional pharmacodynamic parameters of MetS, including reductions in body weight (BW) and fat accumulation, improvement in insulin resistance, regulation of dyslipidemia, prevention of pathological changes in liver, kidney and proximal colon tissue, and suppressive actions against oxidative stress. In particular, the group treated with polyphenols and polysaccharides in combination showed better efficacy. The relative abundance of beneficial bacterial genera Muribaculum and Lachnospiraceae_NK4A136_group were increased to various degrees, while opportunistic pathogens such as Prevotella_2, Bacteroides, Faecalibacterium and Fusobacterium were markedly decreased after treatments. Moreover, fecal metabolite profiles revealed 23 differential metabolites related to treatments with polyphenols and polysaccharides derived from Morus alba L. fruit, individually and in combination. Altogether, these results demonstrated that polyphenols and polysaccharides derived from Morus alba L. fruit attenuated MetS in HFD-fed mice, and improved the gut microbiota composition and fecal metabolite profiles.
C1 [Wan, Meixia; Li, Qing; Lei, Qianya; Zhou, Dan; Wang, Shu] Sichuan Univ, West China Sch Pharm, Chengdu 610041, Peoples R China.
   [Wan, Meixia] Longdong Univ, Qibo Coll Med, Qingyang 745000, Peoples R China.
C3 Sichuan University; Longdong University
RP Wang, S (corresponding author), Sichuan Univ, West China Sch Pharm, Chengdu 610041, Peoples R China.
EM wanmeixia2010@126.com; 18381476874@163.com; lqy2205@126.com;
   wendyzz12@163.com; wang_shu@scu.edu.cn
RI Li, Qing/GZM-3164-2022
FU Sichuan Science and Technology Program [2020YFS0031]; Longdong
   University [XYZK1606]
FX This research was funded by Sichuan Science and Technology Program,
   grant number 2020YFS0031, and Longdong University, grant number
   XYZK1606.
CR Albillos A, 2020, J HEPATOL, V72, P558, DOI 10.1016/j.jhep.2019.10.003
   Aron-Wisnewsky J, 2016, NAT REV NEPHROL, V12, P169, DOI 10.1038/nrneph.2015.191
   Bäckhed F, 2005, SCIENCE, V307, P1915, DOI 10.1126/science.1104816
   Bao L, 2021, DIABET METAB SYND OB, V14, P4671, DOI 10.2147/DMSO.S337979
   Böhler M, 2022, CLIN BIOCHEM, V102, P26, DOI 10.1016/j.clinbiochem.2022.01.009
   Bovolini A, 2021, INT J SPORTS MED, V42, P199, DOI 10.1055/a-1263-0898
   Canfora EE, 2019, NAT REV ENDOCRINOL, V15, P261, DOI 10.1038/s41574-019-0156-z
   Chan AML, 2021, NUTRIENTS, V13, DOI 10.3390/nu13082497
   Chang BY, 2021, FOODS, V10, DOI 10.3390/foods10081966
   Chen M, 2021, J ETHNOPHARMACOL, V268, DOI 10.1016/j.jep.2020.113695
   Chen T, 2022, MOLECULES, V27, DOI 10.3390/molecules27092688
   Chen WG, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039743
   Chu HK, 2019, GUT, V68, P359, DOI 10.1136/gutjnl-2018-316307
   Croci S, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051389
   Crozier A, 2010, MOL ASPECTS MED, V31, P446, DOI 10.1016/j.mam.2010.09.007
   Declèves AE, 2019, J LIPID RES, V60, P937, DOI 10.1194/jlr.M088690
   Do MH, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020301
   Fraga CG, 2019, FOOD FUNCT, V10, P514, DOI [10.1039/c8fo01997e, 10.1039/C8FO01997E]
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Han H, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/3256241
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Henao-Mejia J, 2012, NATURE, V482, P179, DOI 10.1038/nature10809
   Hess PL, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.117.006103
   Hu BF, 2020, PHARMACOL RES, V159, DOI 10.1016/j.phrs.2020.104942
   Hu TG, 2019, FOOD FUNCT, V10, P1513, DOI 10.1039/c9fo00132h
   Huang SM, 2019, FOOD FUNCT, V10, P3224, DOI [10.1039/c9fo00263d, 10.1039/C9FO00263D]
   Innes JK, 2018, PROSTAG LEUKOTR ESS, V132, P41, DOI 10.1016/j.plefa.2018.03.004
   Iwasa M, 2015, OBES RES CLIN PRACT, V9, P293, DOI 10.1016/j.orcp.2015.01.003
   Jiang XW, 2019, CRIT REV FOOD SCI, V59, P921, DOI 10.1080/10408398.2018.1491022
   Jiao YK, 2017, J ETHNOPHARMACOL, V199, P119, DOI 10.1016/j.jep.2017.02.003
   Kasprzak-Drozd K, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22073715
   Kim I, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9030242
   Klaassen CD, 2015, DRUG METAB DISPOS, V43, P1505, DOI 10.1124/dmd.115.065698
   Levy M, 2017, NAT REV IMMUNOL, V17, P219, DOI 10.1038/nri.2017.7
   Lim MY, 2017, GUT, V66, P1031, DOI 10.1136/gutjnl-2015-311326
   Long XS, 2020, FOOD FUNCT, V11, P4249, DOI [10.1039/d0fo00427h, 10.1039/D0FO00427H]
   Lu HF, 2020, J GINSENG RES, V44, P238, DOI 10.1016/j.jgr.2018.10.005
   Ma H, 2022, FOOD SCI HUM WELL, V11, P11, DOI 10.1016/j.fshw.2021.07.002
   Ma LY, 2020, GUT MICROBES, V12, DOI 10.1080/19490976.2020.1832857
   Mafra D, 2014, FUTURE MICROBIOL, V9, P399, DOI 10.2217/fmb.13.165
   Mahboubi M, 2019, PHARMACOL RES, V146, DOI 10.1016/j.phrs.2019.104341
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   Mehedint MG, 2013, CURR OPIN CLIN NUTR, V16, P339, DOI 10.1097/MCO.0b013e3283600d46
   National Pharmacopoeia Commission, 2020, Pharmacopoeia of the People's Republic of China
   Niewiadomska J, 2022, BIOLOGY-BASEL, V11, DOI 10.3390/biology11040559
   Palachai N, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/5972575
   Parker BJ, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.00906
   Poloncová K, 2011, GEN PHYSIOL BIOPHYS, V30, pS25, DOI 10.4149/gpb_2011_SI1_25
   Rau M, 2018, UNITED EUR GASTROENT, V6, P1496, DOI 10.1177/2050640618804444
   Rodrigues EL, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20020301
   Sun CY, 2022, FRONT MICROBIOL, V13, DOI 10.3389/fmicb.2022.859206
   Szeto HH, 2017, J AM SOC NEPHROL, V28, P1437, DOI 10.1681/ASN.2016070761
   Tang C, 2019, FOOD FUNCT, V10, P2290, DOI [10.1039/c8fo01946k, 10.1039/C8FO01946K]
   Turnbaugh PJ, 2009, SCI TRANSL MED, V1, DOI 10.1126/scitranslmed.3000322
   Villard A, 2021, ACTA PHYSIOL, V231, DOI 10.1111/apha.13600
   Wainwright P, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17030367
   Wang YZ, 2021, GUT MICROBES, V13, P1, DOI 10.1080/19490976.2020.1865708
   Watanabe H, 2010, DIABETES-METAB RES, V26, P26, DOI 10.1002/dmrr.1058
   Wei HL, 2018, AM J CHINESE MED, V46, P1743, DOI 10.1142/S0192415X1850088X
   Wu T, 2016, MOL NUTR FOOD RES, V60, P687, DOI 10.1002/mnfr.201500734
   Xie GX, 2014, J PROTEOME RES, V13, P4062, DOI 10.1021/pr500434s
   Yokota A., 2017, Amino Acid Fermentation
   Zeb F, 2020, NUTRITION, V78, DOI 10.1016/j.nut.2020.110797
   Zhang F, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-32958-2
   Zhang HX, 2018, ANTIOXIDANTS-BASEL, V7, DOI 10.3390/antiox7050069
   Zhang Q, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00522
   Zhang TH, 2018, NUTRIENTS, V10, DOI 10.3390/nu10081055
   Zhang ZM, 2021, J CHROMATOGR B, V1174, DOI 10.1016/j.jchromb.2021.122728
NR 68
TC 14
Z9 14
U1 8
U2 74
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD JUN
PY 2022
VL 11
IS 12
AR 1818
DI 10.3390/foods11121818
PG 20
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 2K8ZB
UT WOS:000816616200001
PM 35742014
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Portincasa, P
   Krawczyk, M
   Smyk, W
   Lammert, F
   Di Ciaula, A
AF Portincasa, Piero
   Krawczyk, Marcin
   Smyk, Wiktor
   Lammert, Frank
   Di Ciaula, Agostino
TI COVID-19 and non-alcoholic fatty liver disease: Two intersecting
   pandemics
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Review
DE fatty liver; mitochondria; nitrosative stress; oxidative stress;
   SARS-CoV-2
ID METABOLIC SYNDROME; CLINICAL CHARACTERISTICS; FUNCTIONAL RECEPTOR;
   CARDIOVASCULAR RISK; INSULIN-RESISTANCE; LIFE-STYLE; OBESITY;
   CORONAVIRUS; INFLAMMATION; INJURY
AB Background Initial evidence from China suggests that most vulnerable subjects to COVID-19 infection suffer from pre-existing illness, including metabolic abnormalities. The pandemic characteristics and high-lethality rate of COVID-19 infection have raised concerns about interactions between virus pathobiology and components of the metabolic syndrome. Methods We harmonized the information from the recent existing literature on COVID-19 acute pandemic and mechanisms of damage in non-alcoholic fatty liver disease (NAFLD), as an example of chronic (non-communicable) metabolic pandemic. Results COVID-19-infected patients are more fragile with underlying metabolic illness, including hypertension, cardiovascular disease, type 2 diabetes, chronic lung diseases (e.g. asthma, chronic obstructive pulmonary disease and emphysema) and metabolic syndrome. During metabolic abnormalities, expansion of metabolically active fat ('overfat condition') parallels chronic inflammatory changes, development of insulin resistance and accumulation of fat in configuring NAFLD. The deleterious interplay of inflammatory pathways chronically active in NAFLD and acutely in COVID-19-infected patients, can explain liver damage in a subgroup of patients and might condition a worse outcome in metabolically compromised NAFLD patients. In a subgroup of patients with NAFLD, the underlying liver fibrosis might represent an additional and independent risk factor for severe COVID-19 illness, irrespective of metabolic comorbidities. Conclusions NAFLD can play a role in the outcome of COVID-19 illness due to frequent association with comorbidities. Initial evidences suggest that increased liver fibrosis in NAFLD might affect COVID-19 outcome. In addition, long-term monitoring of post-COVID-19 NAFLD patients is advisable, to document further deterioration of liver damage. Further studies are required in this field.
C1 [Portincasa, Piero; Di Ciaula, Agostino] Univ Bari Aldo Moro, Dept Biomed Sci & Human Oncol, Clin Med A Murri, Bari, Italy.
   [Krawczyk, Marcin; Lammert, Frank] Saarland Univ, Med Ctr, Dept Med 2, Homburg, Germany.
   [Krawczyk, Marcin] Med Univ Warsaw, Ctr Preclin Res, Dept Gen Transplant & Liver Surg, Lab Metab Liver Dis, Warsaw, Poland.
   [Smyk, Wiktor] Med Univ Warsaw, Dept Gen Transplant & Liver Surg, Liver & Internal Med Unit, Warsaw, Poland.
C3 Universita degli Studi di Bari Aldo Moro; Universitatsklinikum des
   Saarlandes; Medical University of Warsaw; Medical University of Warsaw
RP Portincasa, P (corresponding author), Univ Aldo Moro, Dept Biomed Sci & Human Oncol, Clin Med A Murri, Med Sch,Policlin Hosp, Piazza G Cesare 11, I-70124 Bari, Italy.
EM piero.portincasa@uniba.it
RI Krawczyk, Marcin/AAG-4356-2020; portincasa, piero/J-7245-2018; Di
   Ciaula, Agostino/AAW-3499-2021; Di Ciaula, Agostino/M-4300-2017
OI Di Ciaula, Agostino/0000-0002-5476-7376; Krawczyk,
   Marcin/0000-0002-0113-0777; portincasa, piero/0000-0001-5359-1471
FU European Union's Horizon 2020 Research and Innovation framework, under
   the Marie SklodowskaCurie Grant Agreement [734719, 722619]
FX The present paper originates in the context of the projects FOIE GRAS
   (#722619) and mtFOIE GRAS (#734719), which have received funding from
   the European Union's Horizon 2020 Research and Innovation framework,
   under the Marie SklodowskaCurie Grant Agreement.
CR Albano D, 2020, J NUCL MED, V61, P632, DOI 10.2967/jnumed.120.246256
   Bai L, 2019, J MOL MED, V97, P593, DOI 10.1007/s00109-019-01765-1
   Baik I, 2000, ARCH INTERN MED, V160, P3082, DOI 10.1001/archinte.160.20.3082
   Bangash MN, 2020, LANCET GASTROENTEROL, V5, P529, DOI 10.1016/S2468-1253(20)30084-4
   Bellentani S, 2010, DIGEST DIS, V28, P155, DOI 10.1159/000282080
   Bindom SM, 2009, MOL CELL ENDOCRINOL, V302, P193, DOI 10.1016/j.mce.2008.09.020
   Biquard L, 2020, J HEPATOL, V73, P717, DOI 10.1016/j.jhep.2020.04.035
   Boeckmans J, 2020, ARCH TOXICOL, V94, P1367, DOI 10.1007/s00204-020-02734-1
   Byrne CD, 2022, GUT, V71, P1695, DOI 10.1136/gutjnl-2021-325965
   Cai JJ, 2019, HEPATOLOGY, V70, P1026, DOI 10.1002/hep.30506
   Cai JJ, 2019, ANNU REV PATHOL-MECH, V14, P153, DOI 10.1146/annurev-pathmechdis-012418-013003
   Centers for Disease Control and Prevention, 2020, PEOPL WHO AR HIGH RI
   Chai X, 2020, bioRxiv, DOI [10.1101/2020.02.03.931766, 10.1101/2020.02.03.931766]
   Chen JD, 2019, AM J PHYSIOL-ENDOC M, V317, pE710, DOI 10.1152/ajpendo.00052.2019
   Chen JX, 2019, AGING-US, V11, P10839, DOI 10.18632/aging.102488
   Chen T, 2020, BMJ-BRIT MED J, V368, DOI [10.1136/bmj.m1091, 10.1136/bmj.m1295]
   Cholankeril G, 2020, GASTROENTEROLOGY, V159, P775, DOI 10.1053/j.gastro.2020.04.008
   D'Adamo E, 2010, METABOLISM, V59, P671, DOI 10.1016/j.metabol.2009.09.012
   Dar WA, 2019, LIVER INT, V39, DOI 10.1111/liv.14091
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Di Palo DM, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020564
   EASL, 2016, OBESITY FACTS, V9, P65, DOI [10.1159/000443344, 10.1007/s00125-016-3902-y, 10.1016/j.jhep.2015.11.004]
   Eslam M, 2020, GASTROENTEROLOGY, V158, P1999, DOI 10.1053/j.gastro.2019.11.312
   Esser N, 2015, EXPERT OPIN INV DRUG, V24, P283, DOI 10.1517/13543784.2015.974804
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   European Centre for Disease Prevention and Control, 2020, COVID 19 PAND
   Feldman A, 2019, DIABETES METAB, V45, P132, DOI 10.1016/j.diabet.2018.09.003
   Feng G, 2020, J CLIN TRANSL HEPATO, V8, P18, DOI 10.14218/JCTH.2020.00018
   Feng ZJ, 2020, CHINA CDC WEEKLY, V2, P113, DOI [10.3760/cma.j.issn.0254-6450.2020.02.003, 10.46234/ccdcw2020.032]
   Fracanzani AL, 2008, HEPATOLOGY, V48, P792, DOI 10.1002/hep.22429
   Frasca D, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00071
   Fricker ZP, 2019, CLIN GASTROENTEROL H, V17, P1157, DOI 10.1016/j.cgh.2018.11.037
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Gao B, 2016, GASTROENTEROLOGY, V150, P1704, DOI 10.1053/j.gastro.2016.01.025
   Gao QY, 2020, J DIGEST DIS, V21, P125, DOI 10.1111/1751-2980.12851
   Gonzalez FJ, 2018, NAT REV ENDOCRINOL, V15, P21, DOI 10.1038/s41574-018-0096-z
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Grundy SM, 2016, J INVEST MED, V64, P1082, DOI 10.1136/jim-2016-000155
   Grundy SM, 2004, AM J CLIN NUTR, V80, P1
   Gu JY, 2020, GASTROENTEROLOGY, V158, P1518, DOI 10.1053/j.gastro.2020.02.054
   Guan WJ, 2020, NEW ENGL J MED, V382, P1861, DOI 10.1056/NEJMc2005203
   Guo T, 2020, JAMA CARDIOL, V5, P811, DOI 10.1001/jamacardio.2020.1017
   Guo WN, 2020, DIABETES-METAB RES, V36, DOI 10.1002/dmrr.3319
   Hamming I, 2004, J PATHOL, V203, P631, DOI 10.1002/path.1570
   Han SW, 2020, CANCER MED-US, V9, P6667, DOI 10.1002/cam4.3289
   Henry BM, 2020, CLIN CHEM LAB MED, V58, P1021, DOI 10.1515/cclm-2020-0369
   Hernández A, 2020, BBA-MOL BASIS DIS, V1866, DOI 10.1016/j.bbadis.2020.165753
   Hoffmann Markus, 2020, bioRxiv, DOI [10.1016/j.ebiom.2021.103255, 10.1101/2020.08.05.237651]
   Huang CL, 2020, LANCET, V395, P497, DOI 10.1016/S0140-6736(20)30183-5
   Jager J, 2016, J INTERN MED, V280, P209, DOI 10.1111/joim.12483
   Jarrar MH, 2008, ALIMENT PHARM THER, V27, P412, DOI 10.1111/j.1365-2036.2007.03586.x
   Jenne CN, 2013, NAT IMMUNOL, V14, P996, DOI 10.1038/ni.2691
   Ji D, 2020, HEPATOL INT, V14, P701, DOI 10.1007/s12072-020-10058-6
   Jia HP, 2005, J VIROL, V79, P14614, DOI 10.1128/JVI.79.23.14614-14621.2005
   Jones DS, 2020, NEW ENGL J MED, V382, P1681, DOI 10.1056/NEJMp2004361
   Kalligeros M, 2020, OBESITY, V28, P1200, DOI 10.1002/oby.22859
   Kass DA, 2020, LANCET, V395, P1544, DOI 10.1016/S0140-6736(20)31024-2
   Kim LJ, 2011, OBESITY, V19, P1265, DOI 10.1038/oby.2010.291
   Koster A, 2010, OBESITY, V18, P2354, DOI 10.1038/oby.2010.86
   Li J, 2020, J CLIN TRANSL HEPATO, V8, P13, DOI 10.14218/JCTH.2020.00019
   Li WH, 2003, NATURE, V426, P450, DOI 10.1038/nature02145
   Liang WC, 2020, GUT, V69, P1141, DOI 10.1136/gutjnl-2020-320832
   Lin L, 2020, GUT, V69, P997, DOI 10.1136/gutjnl-2020-321013
   Liu DL, 2020, IEEE INT CONF ELECTR, P195, DOI 10.1109/iceiec49280.2020.9152232
   Liu Jing, 2020, EBioMedicine, V55, P102763, DOI 10.1016/j.ebiom.2020.102763
   Ma JT, 2017, J HEPATOL, V66, P390, DOI 10.1016/j.jhep.2016.09.022
   Maddaloni E, 2020, DIABETES-METAB RES, V36, DOI 10.1002/dmrr.3321
   Madjid M, 2021, JAMA CARDIOL, V6, P360, DOI 10.1001/jamacardio.2020.5794
   Maffetone PB, 2017, FRONT PUBLIC HEALTH, V5, DOI 10.3389/fpubh.2017.00290
   Maffetone PB, 2017, FRONT PUBLIC HEALTH, V5, DOI 10.3389/fpubh.2017.00190
   Maffetone PB, 2017, FRONT PUBLIC HEALTH, V4, DOI 10.3389/fpubh.2016.00279
   Mehta P, 2020, LANCET, V395, P1033, DOI 10.1016/S0140-6736(20)30628-0
   Méndez-Sánchez N, 2020, J CLIN TRANSL HEPATO, V8, P109, DOI 10.14218/JCTH.2020.00024
   Molina-Molina E, 2018, EUR J CLIN INVEST, V48, DOI 10.1111/eci.12958
   Molina-Molina E, 2019, CLIN RES HEPATOL GAS, V43, P638, DOI 10.1016/j.clinre.2019.04.005
   Moser JAS, 2019, INFLUENZA OTHER RESP, V13, P3, DOI 10.1111/irv.12618
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Nobel YR, 2020, GASTROENTEROLOGY, V159, P373, DOI 10.1053/j.gastro.2020.04.017
   Nseir WB, 2019, QJM-INT J MED, V112, P95, DOI 10.1093/qjmed/hcy227
   Nseir W, 2011, DIGEST DIS SCI, V56, P3328, DOI 10.1007/s10620-011-1736-5
   Osborn O, 2012, NAT MED, V18, P363, DOI 10.1038/nm.2627
   Paizis G, 2005, GUT, V54, P1790, DOI 10.1136/gut.2004.062398
   Paulsen J, 2017, INT J EPIDEMIOL, V46, P1573, DOI 10.1093/ije/dyx091
   Pedersen SF, 2020, J CLIN INVEST, V130, P2202, DOI 10.1172/JCI137647
   Petrilli Christopher M., 2020, The BMJ, V369, DOI 10.1136/bmj.m1966
   Poulain M, 2006, CAN MED ASSOC J, V174, P1293, DOI 10.1503/cmaj.051299
   Prins GH, 2020, LIVER INT, V40, P2568, DOI 10.1111/liv.14484
   Qi FR, 2020, BIOCHEM BIOPH RES CO, V526, P135, DOI 10.1016/j.bbrc.2020.03.044
   Rinella ME, 2015, JAMA-J AM MED ASSOC, V313, P2263, DOI 10.1001/jama.2015.5370
   Rismanbaf A, 2020, ARCH ACAD EMERG MED, V8
   Rodríguez A, 2010, MED INTENSIVA, V34, P87, DOI 10.1016/j.medin.2009.12.005
   Rothan HA, 2020, J AUTOIMMUN, V109, DOI 10.1016/j.jaut.2020.102433
   Ruderman N, 1998, DIABETES, V47, P699, DOI 10.2337/diabetes.47.5.699
   RUDERMAN NB, 1981, AM J CLIN NUTR, V34, P1617, DOI 10.1093/ajcn/34.8.1617
   Schwimmer JB, 2008, CIRCULATION, V118, P277, DOI 10.1161/CIRCULATIONAHA.107.739920
   Simon TG, 2018, INT J CARDIOL, V259, P198, DOI 10.1016/j.ijcard.2018.01.046
   Simonnet A, 2020, OBESITY, V28, P1195, DOI 10.1002/oby.22831
   Smyk W, 2020, EUR J CLIN INVEST, V50, DOI 10.1111/eci.13276
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Stenholm S, 2010, CLIN ENDOCRINOL, V73, P55, DOI 10.1111/j.1365-2265.2009.03742.x
   The human protein atlas, 2020, ACE2 PROT EXPR SUMM
   Uhlen M, 2015, SCIENCE, V347, DOI 10.1126/science.1260419
   Van Kerkhove MD, 2011, PLOS MED, V8, DOI 10.1371/journal.pmed.1001053
   Vecchié A, 2018, EUR J INTERN MED, V48, P6, DOI 10.1016/j.ejim.2017.10.020
   Verelst F, 2020, EUROSURVEILLANCE, V25, P13, DOI 10.2807/1560-7917.ES.2020.25.13.2000323
   Wang DW, 2020, JAMA-J AM MED ASSOC, V323, P1061, DOI 10.1001/jama.2020.1585
   Wang Y, 2020, RES AGING, V42, P281, DOI 10.1177/0164027520930973
   World Health Organization, 2020, COR DIS COVID 19 PAN
   Xu Zhe, 2020, Lancet Respir Med, V8, P420, DOI 10.1016/S2213-2600(20)30076-X
   Zhang C, 2020, LANCET GASTROENTEROL, V5, P428, DOI 10.1016/S2468-1253(20)30057-1
   Zhao Y, 2020, SINGLE CELL RNA EXPR, DOI DOI 10.1101/2020.01.26.919985
   Zheng KI, 2020, METABOLISM, V108, DOI 10.1016/j.metabol.2020.154244
   Zheng YY, 2020, NAT REV CARDIOL, V17, P259, DOI 10.1038/s41569-020-0360-5
   Zhou F, 2020, LANCET, V395, P1054, DOI 10.1016/S0140-6736(20)30566-3
   Zou X, 2020, FRONT MED-PRC, V14, P185, DOI 10.1007/s11684-020-0754-0
NR 115
TC 92
Z9 96
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD OCT
PY 2020
VL 50
IS 10
AR e13338
DI 10.1111/eci.13338
EA AUG 2020
PG 10
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA NW6XF
UT WOS:000562462900001
PM 32589264
OA Green Published
DA 2025-06-11
ER

PT J
AU Boskovic, M
   Bundalo, M
   Zivkovic, M
   Stanisic, J
   Kostic, M
   Koricanac, G
   Stankovic, A
AF Boskovic, Maja
   Bundalo, Maja
   Zivkovic, Maja
   Stanisic, Jelena
   Kostic, Milan
   Koricanac, Goran
   Stankovic, Aleksandra
TI Estradiol ameliorates antioxidant axis SIRT1-FoxO3a-MnSOD/catalase in
   the heart of fructose-fed ovariectomized rats
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Metabolic syndrome; Fructose; Estradiol; Heart; miRNA
ID ACTIVATED PROTEIN-KINASE; NADPH OXIDASE ACTIVATION; ENERGY SENSING
   NETWORK; OXIDATIVE STRESS; INSULIN-RESISTANCE; VASCULAR DYSFUNCTION;
   FEMALE RATS; RICH DIET; SIRT1; AMPK
AB Harmful effects of fructose-rich diet (FRD) were predominantly observed in males, suggesting protective effects of estrogens. Little is known about AMPK/sirtuin-1 (SIRT1)/forkhead box O3 (FoxO3a)/manganese superoxide dismutase (MnSOD)/catalase signaling in the heart in state of metabolic syndrome and oxidative stress induced by fructose over-consumption. We investigated the effect of 10% FRD on expression of AMPK-SIRT1-FoxO3a-MnSOD/catalase axis in myocardium and potentially beneficial effect of 17 beta-estradiol replacement. The expression of NADPH oxidase 4 (Nox4) and miRNA-155, unfavorable regulators of this axis, were also investigated. FRD significantly increased AMPK and decreased FoxO3a activity, decreased SIRT1, MnSOD and Nox4 protein expression while E2 reverted these changes, except for Nox4, and increased catalase protein level. E2 diminished Nox4 and MnSOD mRNA level in FRD ovariectomized rats. These results suggest independent response of AMPK and SIRT to FRD treatment. The proposed signaling in the heart should be further investigated in the prooxidative and antioxidative milieu.
C1 [Boskovic, Maja; Bundalo, Maja; Zivkovic, Maja; Stankovic, Aleksandra] Univ Belgrade, Vinca Inst Nucl Sci, Lab Radiobiol & Mol Genet, Belgrade, Serbia.
   [Stanisic, Jelena; Kostic, Milan; Koricanac, Goran] Univ Belgrade, Vinca Inst Nucl Sci, Lab Mol Biol & Endocrinol, Belgrade, Serbia.
   [Bundalo, Maja] Univ Hosp Wurzburg, Inst Expt Biomed, Wurzburg, Germany.
C3 University of Belgrade; University of Belgrade; University of Wurzburg
RP Stankovic, A (corresponding author), Vinca Inst Nucl Sci, Lab Radiobiol & Mol Genet, POB 522, Belgrade 11000, Serbia.
EM alexas@vinca.rs
RI Korićanac, Goran/ABF-6544-2021; Stankovic, Aleksandra/T-1064-2018;
   Kostic, Milan/IUM-1526-2023; Zivkovic, Maja/T-1038-2018
OI Zivkovic, Maja/0000-0002-0447-6626; Kostic, Milan/0000-0003-4680-5835;
   Boskovic, Maja/0000-0003-0167-2522; Jakovljevic,
   Jelena/0000-0002-4365-9169; Koricanac, Goran/0000-0002-9852-3330
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [OI175085, III 41009]
FX This work was supported by The Ministry of Education, Science and
   Technological Development of the Republic of Serbia (grant numbers
   OI175085, III 41009).
CR Akar F, 2012, FOOD CHEM TOXICOL, V50, P2135, DOI 10.1016/j.fct.2012.03.061
   Arias-Loza PA, 2013, PFLUG ARCH EUR J PHY, V465, P739, DOI 10.1007/s00424-013-1247-7
   Behr M, 2011, FOOD CHEM TOXICOL, V49, P2681, DOI 10.1016/j.fct.2011.07.039
   Boily G, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001759
   Brown LM, 2010, J STEROID BIOCHEM, V122, P65, DOI 10.1016/j.jsbmb.2009.12.005
   Bundalo M, 2015, HORM METAB RES, V47, P521, DOI 10.1055/s-0034-1394373
   Bundalo M, 2017, EUR J PHARMACOL, V811, P141, DOI 10.1016/j.ejphar.2017.06.003
   Campos C, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/218749
   Cantó C, 2009, NATURE, V458, P1056, DOI 10.1038/nature07813
   Cantó C, 2009, CURR OPIN LIPIDOL, V20, P98, DOI 10.1097/MOL.0b013e328328d0a4
   Cavarape A, 2001, J ENDOCRINOL INVEST, V24, P838, DOI 10.1007/BF03343940
   Cha SH, 2008, P NATL ACAD SCI USA, V105, P16871, DOI 10.1073/pnas.0809255105
   Chen D, 2008, GENE DEV, V22, P1753, DOI 10.1101/gad.1650608
   Cheng L, 2010, J CARD FAIL, V16, pS35, DOI 10.1016/j.cardfail.2010.06.118
   Cheng PW, 2014, BRIT J PHARMACOL, V171, P2739, DOI 10.1111/bph.12648
   Cohen HY, 2004, SCIENCE, V305, P390, DOI 10.1126/science.1099196
   Conti FF, 2014, BMC CARDIOVASC DISOR, V14, DOI 10.1186/1471-2261-14-185
   Delbosc S, 2005, ATHEROSCLEROSIS, V179, P43, DOI 10.1016/j.atherosclerosis.2004.10.018
   Federico M, 2017, J PHYSIOL-LONDON, V595, P4089, DOI 10.1113/JP273714
   Flues K, 2010, MATURITAS, V65, P267, DOI 10.1016/j.maturitas.2009.11.007
   FRIDOVICH I, 1995, ANNU REV BIOCHEM, V64, P97, DOI 10.1146/annurev.bi.64.070195.000525
   Fulco M, 2008, DEV CELL, V14, P661, DOI 10.1016/j.devcel.2008.02.004
   Galipeau D, 2002, AM J PHYSIOL-HEART C, V283, pH2478, DOI 10.1152/ajpheart.00243.2002
   Ginsburg ES, 1998, GYNECOL OBSTET INVES, V45, P45, DOI 10.1159/000009923
   Gray SP, 2016, ARTERIOSCL THROM VAS, V36, P295, DOI 10.1161/ATVBAHA.115.307012
   Hawley SA, 2005, CELL METAB, V2, P9, DOI 10.1016/j.cmet.2005.05.009
   Hou XY, 2008, J BIOL CHEM, V283, P20015, DOI 10.1074/jbc.M802187200
   Zarzuelo MJ, 2013, BIOCHEM PHARMACOL, V85, P1288, DOI 10.1016/j.bcp.2013.02.015
   Klotz LO, 2015, REDOX BIOL, V6, P51, DOI 10.1016/j.redox.2015.06.019
   Koo HY, 2009, BIOCHEM BIOPH RES CO, V390, P285, DOI 10.1016/j.bbrc.2009.09.109
   Kops GJPL, 2002, NATURE, V419, P316, DOI 10.1038/nature01036
   Koricanac G, 2009, CELL BIOCHEM FUNCT, V27, P102, DOI 10.1002/cbf.1542
   Kuroda J, 2010, P NATL ACAD SCI USA, V107, P15565, DOI 10.1073/pnas.1002178107
   Lan F, 2008, J BIOL CHEM, V283, P27628, DOI 10.1074/jbc.M805711200
   Lanaspa MA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048801
   Li Y, 2014, BIOCHEM BIOPH RES CO, V455, P113, DOI 10.1016/j.bbrc.2014.10.123
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   MAENPAA PH, 1968, SCIENCE, V161, P1253, DOI 10.1126/science.161.3847.1253
   Mesnage R, 2017, FOOD CHEM TOXICOL, V108, P30, DOI 10.1016/j.fct.2017.07.025
   Nagata D, 2004, CIRCULATION, V110, P444, DOI 10.1161/01.CIR.0000136025.96811.76
   Nanni S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0062522
   Noriega LG, 2011, EMBO REP, V12, P1069, DOI 10.1038/embor.2011.151
   Nyby MD, 2007, HYPERTENS RES, V30, P451, DOI 10.1291/hypres.30.451
   Olmos Y, 2013, ANTIOXID REDOX SIGN, V19, P1507, DOI 10.1089/ars.2012.4713
   Papadimitriou A, 2015, AM J PHYSIOL-RENAL, V308, pF209, DOI 10.1152/ajprenal.00252.2014
   Patel S, 2018, BIOMED PHARMACOTHER, V102, P403, DOI 10.1016/j.biopha.2018.03.078
   Patisaul HB, 2010, FRONT NEUROENDOCRIN, V31, P400, DOI 10.1016/j.yfrne.2010.03.003
   Pektas MB, 2015, CELL PHYSIOL BIOCHEM, V37, P1407, DOI 10.1159/000430405
   Price NL, 2012, CELL METAB, V15, P675, DOI 10.1016/j.cmet.2012.04.003
   Rabinovitch RC, 2017, CELL REP, V21, P1, DOI 10.1016/j.celrep.2017.09.026
   Radika Mutlur Krishnamoorthy, 2015, Journal of Basic and Clinical Physiology and Pharmacology, V26, P563, DOI 10.1515/jbcpp-2014-0122
   Rattanavichit Y, 2016, AM J PHYSIOL-REG I, V311, pR1200, DOI 10.1152/ajpregu.00230.2016
   Romero-Calvo I, 2010, ANAL BIOCHEM, V401, P318, DOI 10.1016/j.ab.2010.02.036
   Ruderman NB, 2013, J CLIN INVEST, V123, P2764, DOI 10.1172/JCI67227
   Ruderman NB, 2010, AM J PHYSIOL-ENDOC M, V298, pE751, DOI 10.1152/ajpendo.00745.2009
   Schröder K, 2012, CIRC RES, V110, P1217, DOI 10.1161/CIRCRESAHA.112.267054
   Shen T, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/713894
   Stirone C, 2005, MOL PHARMACOL, V68, P959, DOI 10.1124/mol.105.014662
   Strehlow K, 2003, CIRC RES, V93, P170, DOI 10.1161/01.RES.0000082334.17947.11
   Suchankova G, 2009, BIOCHEM BIOPH RES CO, V378, P836, DOI 10.1016/j.bbrc.2008.11.130
   Sun Y, 2014, PHARMACOL RES, V89, P19, DOI 10.1016/j.phrs.2014.07.006
   Suwa M, 2008, METABOLISM, V57, P986, DOI 10.1016/j.metabol.2008.02.017
   Tan WQ, 2008, J BIOL CHEM, V283, P29730, DOI 10.1074/jbc.M805514200
   Tran LT, 2009, MOL CELL BIOCHEM, V332, P145, DOI 10.1007/s11010-009-0184-4
   Vasudevan H, 2005, AM J PHYSIOL-HEART C, V289, pH1335, DOI 10.1152/ajpheart.00399.2005
   Vogel C, 2012, NAT REV GENET, V13, P227, DOI 10.1038/nrg3185
   Yamakuchi M, 2008, P NATL ACAD SCI USA, V105, P13421, DOI 10.1073/pnas.0801613105
   Yamamoto M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016841
   Zakula Z, 2011, EUR J NUTR, V50, P543, DOI 10.1007/s00394-010-0161-4
   Zhang T, 2002, J BIOL CHEM, V277, P1261, DOI 10.1074/jbc.M108525200
NR 70
TC 7
Z9 8
U1 0
U2 26
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JAN
PY 2019
VL 52
BP 690
EP 698
DI 10.1016/j.jff.2018.11.053
PG 9
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA HH4KR
UT WOS:000455691800073
DA 2025-06-11
ER

PT J
AU Nour, OA
   Ghoniem, HA
   Nader, MA
   Suddek, GM
AF Nour, Omnia A.
   Ghoniem, Hamdy A.
   Nader, Manar A.
   Suddek, Ghada M.
TI Impact of protocatechuic acid on high fat diet-induced metabolic
   syndrome sequelae in rats
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE High fat diet; Metabolic syndrome; Protocatechuic acid; Adiponectin;
   pAkt; Free fatty acids; IL-1b
ID ADIPOSE-TISSUE DYSFUNCTION; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   ESTABLISHED ATHEROSCLEROSIS; ENDOTHELIAL DYSFUNCTION; RISK-FACTORS;
   BETA-CELL; OBESITY; ADIPONECTIN; GLUCOSE
AB The study aimed to assess the possible protective impact of protocatechuic acid (PCA) on high fat diet (HFD)induced metabolic syndrome (Mets) sequelae in rats. Forty-two male Sprague-Dawley (SD) rats were randomly grouped as follows: CTR group; PCA group; HFD group; HFD-PCA group and HFD-MET group. Rats were fed on standard diet or HFD for 14 weeks. HFD-fed rats exhibited significant decreases in food intake and adiponectin (ADP) level; yet, body weight and anthropometrical parameters were significantly increased. Moreover, insulin sensitivity was impaired as indicated by significant elevation in glucose AUC during oral glucose tolerance test (OGTT), fasting serum glucose, fasting serum insulin and homeostasis model assessment of insulin resistance (HOMA-IR) index. Furthermore, chronic HFD feeding elicited significant increases in serum lipid profile and free fatty acids (FFAs) with concomitant hepatic steatosis. Additionally, serum C-reactive protein (CRP), interleukin 1b (Il-1b) and monocyte chemoattractant protein 1(MCP-1) levels were increased. Also, HFD-fed rats exhibited an increase in MDA level, while superoxide dismutase (SOD) and glutathione (GSH) activities were decreased. Moreover, the insulin-signaling pathway was markedly impaired in soleus muscles as indicated by a decrease in insulin-induced AKT phosphorylation. Histopathologically, adipose tissues showed significant increase in adipocyte size. Also, flow cytometry analysis of adipose tissue confirmed a significant increase in the percentage of number of CD68+ cells. PCA administration succeeded to attenuate HFD-induced obesity, insulin resistance, oxidative stress and inflammation. In conclusion, PCA administration could protect against HFD-induced Mets, possibly via its hypoglycemic, insulin-sensitizing, anti-oxidant and anti-inflammatory effects.
C1 [Nour, Omnia A.; Ghoniem, Hamdy A.; Nader, Manar A.; Suddek, Ghada M.] Mansoura Univ, Fac Pharm, Dept Pharmacol & Toxicol, Mansoura, Egypt.
C3 Egyptian Knowledge Bank (EKB); Mansoura University
RP Nour, OA (corresponding author), Mansoura Univ, Fac Pharm, Dept Pharmacol & Toxicol, Mansoura, Egypt.
EM asilsamy@gmail.com
RI Suddek, Ghada/HPE-4718-2023
OI Suddek, Ghada/0000-0002-3283-9471
CR Abeyrathna P, 2015, VASC PHARMACOL, V74, P38, DOI 10.1016/j.vph.2015.05.008
   Ablat A, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1610-x
   Al Olayan EM, 2020, SCI TOTAL ENVIRON, V723, DOI 10.1016/j.scitotenv.2020.137969
   Amar J, 2011, EMBO MOL MED, V3, P559, DOI 10.1002/emmm.201100159
   Amini FG, 2012, J RES MED SCI, V17, P621
   Bays HE, 2013, J CLIN LIPIDOL, V7, P304, DOI 10.1016/j.jacl.2013.04.001
   Bhattacharjee N, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00251
   Brunner H, 2005, J HYPERTENS, V23, P233, DOI 10.1097/00004872-200502000-00001
   Chan J, 2016, DRUG METAB DISPOS, V44, P534, DOI 10.1124/dmd.115.067942
   Choi BK, 2016, ASIAN PAC J TROP MED, V9, P616, DOI 10.1016/j.apjtm.2016.05.017
   Cnop M, 2003, DIABETOLOGIA, V46, P459, DOI 10.1007/s00125-003-1074-z
   Condorelli RA, 2013, J ENDOCRINOL INVEST, V36, P770, DOI 10.3275/8950
   Dai SS, 2018, BIOMED PHARMACOTHER, V100, P93, DOI 10.1016/j.biopha.2018.01.111
   Delahaye LB, 2018, APPL PHYSIOL NUTR ME, V43, P1033, DOI 10.1139/apnm-2017-0706
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   El-Magd NFA, 2018, LIFE SCI, V193, P159, DOI 10.1016/j.lfs.2017.11.005
   El-Sonbaty YA, 2019, BIOCHIMIE, V167, P119, DOI 10.1016/j.biochi.2019.09.011
   ELLMAN GL, 1959, ARCH BIOCHEM BIOPHYS, V82, P70, DOI 10.1016/0003-9861(59)90090-6
   Fasshauer M, 2004, FEBS LETT, V558, P27, DOI 10.1016/S0014-5793(03)01525-4
   Fasshauer M, 2015, TRENDS PHARMACOL SCI, V36, P461, DOI 10.1016/j.tips.2015.04.014
   Fitzgibbons TP, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.113.000582
   Frayn KN, 2001, P NUTR SOC, V60, P375, DOI 10.1079/PNS200195
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Goossens GH, 2008, PHYSIOL BEHAV, V94, P206, DOI 10.1016/j.physbeh.2007.10.010
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Han L, 2019, J AGR FOOD CHEM, V67, P7060, DOI 10.1021/acs.jafc.9b02647
   Harini R, 2010, REDOX REP, V15, P71, DOI 10.1179/174329210X12650506623285
   Hassan S, 2011, SAUDI J BIOL SCI, V18, P333, DOI 10.1016/j.sjbs.2011.01.005
   Hattori Y, 2003, DIABETOLOGIA, V46, P1543, DOI 10.1007/s00125-003-1224-3
   HernandezMunoz R, 1997, HEPATOLOGY, V26, P1100
   Kalupahana NS, 2012, MOL ASPECTS MED, V33, P26, DOI 10.1016/j.mam.2011.10.011
   Kang ZC, 2013, BASIC CLIN PHARMACOL, V113, P221, DOI 10.1111/bcpt.12094
   Khan AK, 2015, ACTA POL PHARM, V72, P643
   Kietadisorn R, 2012, AM J PHYSIOL-ENDOC M, V302, pE481, DOI 10.1152/ajpendo.00540.2011
   Klop B, 2013, NUTRIENTS, V5, P1218, DOI 10.3390/nu5041218
   Koene RJ, 2016, CIRCULATION, V133, P1104, DOI 10.1161/CIRCULATIONAHA.115.020406
   Laakso M, 2015, CURR DIABETES REP, V15, DOI 10.1007/s11892-015-0684-4
   Lauby-Secretan B, 2016, NEW ENGL J MED, V375, P794, DOI 10.1056/NEJMsr1606602
   Le JM, 2018, BIOCHEM BIOPH RES CO, V500, P484, DOI 10.1016/j.bbrc.2018.04.108
   Levine YC, 2007, J BIOL CHEM, V282, P20351, DOI 10.1074/jbc.M702182200
   Lewis GF, 1997, DIABETES, V46, P1111, DOI 10.2337/diabetes.46.7.1111
   Li Q, 2020, INFLAMM RES, V69, P1027, DOI 10.1007/s00011-020-01379-1
   Li XH, 2018, IRAN J BASIC MED SCI, V21, P502, DOI 10.22038/IJBMS.2018.27346.6674
   Liang YJ, 2019, PROBIOTICS ANTIMICRO, V11, P175, DOI 10.1007/s12602-017-9378-3
   Lin WQ, 2015, MOL NUTR FOOD RES, V59, P1803, DOI 10.1002/mnfr.201400925
   Lin YK, 2009, J ETHNOPHARMACOL, V125, P51, DOI 10.1016/j.jep.2009.06.014
   Lionetti L, 2007, INT J OBESITY, V31, P1596, DOI 10.1038/sj.ijo.0803636
   Liu CQ, 2016, MOL NUTR FOOD RES, V60, P2141, DOI 10.1002/mnfr.201600002
   Maithilikarpagaselvi Nachimuthu, 2016, J Complement Integr Med, V13, P137, DOI 10.1515/jcim-2015-0070
   Manna P, 2015, METAB SYNDR RELAT D, V13, P423, DOI 10.1089/met.2015.0095
   Manning BD, 2017, CELL, V169, P381, DOI 10.1016/j.cell.2017.04.001
   MARKLUND S, 1974, EUR J BIOCHEM, V47, P469
   Masella R, 2012, CURR MED CHEM, V19, P2901
   Matheus VA, 2017, EXP BIOL MED, V242, P1214, DOI 10.1177/1535370217708188
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   McCuskey RS, 2004, HEPATOLOGY, V40, P386, DOI 10.1002/hep.20302
   McGown C, 2014, CLIN LIVER DIS, V18, P41, DOI 10.1016/j.cld.2013.09.012
   Moreira PI, 2010, METHODS MOL BIOL, V610, P419, DOI 10.1007/978-1-60327-029-8_25
   Mori Y, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0947-5
   Novelli ELB, 2007, LAB ANIM-UK, V41, P111, DOI 10.1258/002367707779399518
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   Okuno Y, 2018, DIABETES, V67, P1113, DOI 10.2337/db17-1032
   Ormazabal P, 2018, INT J OBESITY, V42, P2012, DOI 10.1038/s41366-018-0075-4
   Othman A.I., 2019, Clinical Phytoscience, V5, P48, DOI DOI 10.1186/S40816-019-0140-0
   PAIGEN B, 1987, ATHEROSCLEROSIS, V64, P215, DOI 10.1016/0021-9150(87)90249-8
   Panee J, 2012, CYTOKINE, V60, P1, DOI 10.1016/j.cyto.2012.06.018
   PEPYS MB, 1977, CLIN EXP IMMUNOL, V30, P32
   Polyzos SA, 2012, J CLIN GASTROENTEROL, V46, P272, DOI 10.1097/MCG.0b013e31824587e0
   Poudyal H, 2010, J NUTR, V140, P946, DOI 10.3945/jn.109.117812
   Qatanani M, 2007, GENE DEV, V21, P1443, DOI 10.1101/gad.1550907
   Reilly MP, 2003, CIRCULATION, V108, P1546, DOI 10.1161/01.CIR.0000088846.10655.E0
   Roberts CK, 2013, COMPR PHYSIOL, V3, P1, DOI 10.1002/cphy.c110062
   Rospond B, 2019, PHARMACOL REP, V71, P1, DOI 10.1016/j.pharep.2018.09.005
   Rudich A, 1998, DIABETES, V47, P1562, DOI 10.2337/diabetes.47.10.1562
   Sacks FM, 2015, CURR OPIN LIPIDOL, V26, P56, DOI 10.1097/MOL.0000000000000146
   Safaeian L, 2018, BIOMED PHARMACOTHER, V100, P147, DOI 10.1016/j.biopha.2018.01.107
   Scazzocchio B, 2015, MOL NUTR FOOD RES, V59, P1472, DOI 10.1002/mnfr.201400816
   Schenk S, 2008, J CLIN INVEST, V118, P2992, DOI 10.1172/JCI34260
   Singh GM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0065174
   Srinivasan K, 2005, PHARMACOL RES, V52, P313, DOI 10.1016/j.phrs.2005.05.004
   Suganami T, 2005, ARTERIOSCL THROM VAS, V25, P2062, DOI 10.1161/01.ATV.0000183883.72263.13
   Tinkov AA, 2015, J TRACE ELEM MED BIO, V29, P176, DOI 10.1016/j.jtemb.2014.07.006
   Turer AT, 2012, DIABETOLOGIA, V55, P2319, DOI 10.1007/s00125-012-2598-x
   Wang Y, 2019, MOL MED, V25, DOI 10.1186/s10020-019-0075-4
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Wiesenthal SR, 1999, DIABETES, V48, P766, DOI 10.2337/diabetes.48.4.766
   Williams EP, 2015, CURR OBES REP, V4, P363, DOI 10.1007/s13679-015-0169-4
   Xiao CT, 2016, DIABETES, V65, P1767, DOI 10.2337/db16-0046
   Xu XL, 2019, CONNECT TISSUE RES, V60, P571, DOI 10.1080/03008207.2019.1601187
   Yamauchi T, 2002, NAT MED, V8, P1288, DOI 10.1038/nm788
   Yang LL, 2014, FREE RADICAL BIO MED, V68, P260, DOI 10.1016/j.freeradbiomed.2013.12.026
   Yang ZH, 2006, CLIN MED RES, V4, P53, DOI 10.3121/cmr.4.1.53
   Yao QY, 2019, J BIOL CHEM, V294, P3284, DOI [10.1074/jbc.ra118.004411, 10.1074/jbc.RA118.004411]
   Yu YH, 2005, CIRC RES, V96, P1042, DOI 10.1161/01.RES.0000165803.47776.38
NR 96
TC 12
Z9 12
U1 0
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD SEP 15
PY 2021
VL 907
AR 174257
DI 10.1016/j.ejphar.2021.174257
EA JUN 2021
PG 19
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA UF3DO
UT WOS:000688457500001
PM 34129881
DA 2025-06-11
ER

PT J
AU Shearer, GC
   Borkowski, K
   Puumala, SL
   Harris, WS
   Pedersen, TL
   Newman, JW
AF Shearer, Gregory C.
   Borkowski, Kamil
   Puumala, Susan L.
   Harris, William S.
   Pedersen, Theresa L.
   Newman, John W.
TI Abnormal lipoprotein oxylipins in metabolic syndrome and partial
   correction by omega-3 fatty acids
SO PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
LA English
DT Article
DE Lipoproteins; VLDL; LDL; HDL; Oxylipins; Lipid mediators; Epoxides;
   Metabolic syndrome; Omega-3 fatty acids; EPA; DHA; Omega-3 acid ethyl
   esters
ID ACTIVATES PPAR-ALPHA; EPOXYEICOSATRIENOIC ACIDS; ENDOTHELIAL-CELLS;
   LIPID MEDIATORS; FATTY-ACIDS; CHOLESTEROL; VLDL; RESOLUTION; HYDROLYSIS;
   OVERWEIGHT
AB Metabolic syndrome (MetSyn) is characterized by chronic inflammation which mediates the associated high risk for cardiovascular and other diseases. Oxylipins are a superclass of lipid mediators with potent bioactivities in inflammation, vascular biology, and more. While their role as locally produced agents is appreciated, most oxylipins in plasma are found in lipoproteins suggesting defective regulation of inflammation could be mediated by the elevated VLDL and low HDL levels characteristic of MetSyn. Our objective was to compare the oxylipin composition of VLDL, LDL, and HDL in 14 optimally healthy individuals and 31 MetSyn patients, and then to determine the effects of treating MetSyn subjects with 4 g/day of prescription omega-3 fatty acids (P-OM3) on lipoprotein oxylipin profiles. We compared oxylipin compositions of healthy (14) and MetSyn (31) subjects followed by randomization and assignment to 4 g/d P-OM3 for 16 weeks using LC/MS/MS. Compared to healthy subjects, MetSyn is characterized by abnormalities of (1) pro-inflammatory, arachidonate-derived oxylipins from the lipoxygenase pathway in HDL; and (2) oxylipins mostly not derived from arachidonate in VLDL. P-OM3 treatment corrected many components of these abnormalities, reducing the burden of inflammatory mediators within peripherally circulating lipoproteins that could interfere with, or enhance, local effectors of inflammatory stress. We conclude that MetSyn is associated with a disruption of lipoprotein oxylipin patterns consistent with greater inflammatory stress, and the partial correction of these dysoxylipinemias by treatment with omega-3 fatty acids could explain some of their beneficial effects.
C1 [Shearer, Gregory C.; Puumala, Susan L.; Harris, William S.] Sanford Res, Sioux Falls, SD USA.
   [Shearer, Gregory C.; Harris, William S.] Univ South Dakota, Sanford Sch Med, Sioux Falls, SD USA.
   [Shearer, Gregory C.; Borkowski, Kamil] Penn State Univ, Dept Nutr Sci, University Pk, PA 16802 USA.
   [Borkowski, Kamil] Univ Calif Davis, UC Davis Genome Ctr, West Coast Metabol Ctr, Davis, CA 95616 USA.
   [Pedersen, Theresa L.; Newman, John W.] ARS, Obes & Metab Res Unit, USDA, Western Human Nutr Res Ctr, Davis, CA USA.
   [Newman, John W.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
C3 Sanford Health; University of South Dakota; Pennsylvania Commonwealth
   System of Higher Education (PCSHE); Pennsylvania State University; Penn
   State Behrend; Pennsylvania State University - University Park;
   University of California System; University of California Davis; United
   States Department of Agriculture (USDA); University of California
   System; University of California Davis
RP Shearer, GC (corresponding author), Penn State Univ, 110 Chandlee Lab, University Pk, PA 16802 USA.
EM gcs13@psu.edu
RI Shearer, Gregory/B-7309-2014; Harris, William/T-1674-2019
OI Newman, John/0000-0001-9632-6571; Puumala, Susan/0000-0002-6850-6855
FU National Institute of Health [5 R01 DK061486, U24 DK097154]; Abbott
   (Niaspan); GlaxoSmithKline (Lovaza) [LVZ113350]; USDA
   [5306-51530-019-00D, 2032-51530-022-00D]; GlaxoSmithKline [LVZ113350]
FX National Institute of Health (5 R01 DK061486, U24 DK097154) and
   pharmaceuticals from Abbott (Niaspan) and GlaxoSmithKline (Lovaza &
   grant support - LVZ113350), and USDA intramural projects
   5306-51530-019-00D and 2032-51530-022-00D.
CR Ahmed W, 2006, CIRC RES, V98, P490, DOI 10.1161/01.RES.0000205846.46812.be
   Assmann G, 2007, EUR J CLIN INVEST, V37, P925, DOI 10.1111/j.1365-2362.2007.01888.x
   Augustine AH, 2014, PROSTAG LEUKOTR ESS, V90, P69, DOI 10.1016/j.plefa.2013.12.003
   Bittner V, 2009, AM HEART J, V157, P548, DOI 10.1016/j.ahj.2008.11.014
   Block RC, 2010, PROSTAG LEUKOTR ESS, V82, P87, DOI 10.1016/j.plefa.2009.12.005
   Borja MS, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0182217
   Brown JE, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024124
   Campbell WB, 1996, CIRC RES, V78, P415, DOI 10.1161/01.RES.78.3.415
   Chen JH, 2011, CIRCULATION, V123, P584, DOI 10.1161/CIRCULATIONAHA.110.971853
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Davidson MH, 2007, CLIN THER, V29, P1354, DOI 10.1016/j.clinthera.2007.07.018
   De Felice C, 2012, GENES NUTR, V7, P447, DOI 10.1007/s12263-012-0285-7
   Dichtl W, 1999, CIRC RES, V84, P1085, DOI 10.1161/01.RES.84.9.1085
   Fang X, 1999, HYPERTENSION, V34, P1242, DOI 10.1161/01.HYP.34.6.1242
   Fornoni A, 2005, CURR HYPERTENS REP, V7, P88, DOI 10.1007/s11906-005-0080-6
   Gentleman RC, 2004, GENOME BIOL, V5, DOI 10.1186/gb-2004-5-10-r80
   Gertow K, 2011, ATHEROSCLEROSIS, V215, P411, DOI 10.1016/j.atherosclerosis.2011.01.015
   Grant GE, 2009, PROSTAG OTH LIPID M, V89, P98, DOI 10.1016/j.prostaglandins.2009.05.002
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Harris W S, 1997, J Cardiovasc Risk, V4, P385, DOI 10.1097/00043798-199710000-00011
   Harris WS, 2004, PREV MED, V39, P212, DOI 10.1016/j.ypmed.2004.02.030
   Hersberger M, 2003, DRUGS, V63, P1907, DOI 10.2165/00003495-200363180-00003
   HU SL, 1993, EUR J PHARMACOL, V230, P215, DOI 10.1016/0014-2999(93)90805-R
   Itoh T, 2008, NAT STRUCT MOL BIOL, V15, P924, DOI 10.1038/nsmb.1474
   Johnson WE, 2007, BIOSTATISTICS, V8, P118, DOI 10.1093/biostatistics/kxj037
   Keenan A.H., 2012, Journal of Lipid Research
   KINSELL LW, 1961, DIABETES, V10, P316, DOI 10.2337/diab.10.4.316
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Langfelder P, 2008, BMC BIOINFORMATICS, V9, DOI 10.1186/1471-2105-9-559
   Lazarus SC, 1998, AM J MANAG CARE, V4, P841
   Leek J. T., 2011, SVA SURROGATE VARIAB
   Luria A, 2007, J BIOL CHEM, V282, P2891, DOI 10.1074/jbc.M608057200
   Newman J. W., 2007, J LIPID RES
   Newman JW, 2007, J LIPID RES, V48, P1792, DOI 10.1194/jlr.M700146-JLR200
   Newman JW, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0111471
   Pallast S, 2010, J CEREBR BLOOD F MET, V30, P1157, DOI 10.1038/jcbfm.2009.281
   Ruby MA, 2010, J LIPID RES, V51, P2275, DOI 10.1194/jlr.M005561
   Savinova OV, 2015, ATHEROSCLEROSIS, V240, P520, DOI 10.1016/j.atherosclerosis.2015.04.793
   Savinova OV, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0104833
   Schwab JM, 2006, CURR OPIN PHARMACOL, V6, P414, DOI 10.1016/j.coph.2006.02.006
   Serhan CN, 2014, NATURE, V510, P92, DOI 10.1038/nature13479
   Shearer GC, 2012, J LIPID RES, V53, P2429, DOI 10.1194/jlr.P022392
   Shearer GC, 2010, J LIPID RES, V51, P2074, DOI 10.1194/M900193-JLR200
   Shearer GC, 2008, PROSTAG LEUKOTR ESS, V79, P215, DOI 10.1016/j.plefa.2008.09.023
   Ting HJ, 2007, CIRC RES, V100, P381, DOI 10.1161/01.RES.0000258023.76515.a3
   Tschernatsch MMO, 2006, ATHEROSCLEROSIS, V189, P310, DOI 10.1016/j.atherosclerosis.2006.01.007
   Vriens J, 2005, CIRC RES, V97, P908, DOI 10.1161/01.RES.0000187474.47805.30
   Wang LM, 2009, J LIPID RES, V50, P204, DOI 10.1194/jlr.M700505-JLR200
   Whatling C, 2007, EXPERT OPIN INV DRUG, V16, P1879, DOI 10.1517/13543784.16.12.1879
   Wittwer J, 2007, PROSTAG LEUKOTR ESS, V77, P67, DOI 10.1016/j.plefa.2007.08.001
   Yokoyama M, 2007, LANCET, V369, P1090, DOI 10.1016/S0140-6736(07)60527-3
   Ziouzenkova O, 2003, P NATL ACAD SCI USA, V100, P2730, DOI 10.1073/pnas.0538015100
NR 52
TC 36
Z9 39
U1 1
U2 7
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0952-3278
EI 1532-2823
J9 PROSTAG LEUKOTR ESS
JI Prostaglandins Leukot. Essent. Fatty Acids
PD JAN
PY 2018
VL 128
BP 1
EP 10
DI 10.1016/j.plefa.2017.10.006
PG 10
WC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
GA FW3IZ
UT WOS:000425201400002
PM 29413356
OA Bronze
DA 2025-06-11
ER

PT J
AU Rodriguez-Iturbe, B
   Johnson, RJ
   Lanaspa, MA
   Nakagawa, T
   Garcia-Arroyo, FE
   Sánchez-Lozada, LG
AF Rodriguez-Iturbe, Bernardo
   Johnson, Richard J.
   Lanaspa, Miguel A.
   Nakagawa, Takahiko
   Garcia-Arroyo, Fernando E.
   Sanchez-Lozada, Laura G.
TI Sirtuin deficiency and the adverse effects of fructose and uric acid
   synthesis
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Review
DE fructose; metabolic syndrome; NAD(+); sirtuins; uric acid
ID FATTY LIVER-DISEASE; CHRONIC KIDNEY-DISEASE; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; MITOCHONDRIAL DYSFUNCTION; ENDOTHELIAL DYSFUNCTION;
   NAD(+) HOMEOSTASIS; HEPATIC STEATOSIS; ACTIVATION; HYPERURICEMIA
AB Fructose metabolism and hyperuricemia have been shown to drive insulin resistance, metabolic syndrome, hepatic steatosis, hypertension, inflammation, and innate immune reactivity in experimental studies. We suggest that these adverse effects are at least in part the result of suppressed activity of sirtuins, particularly Sirtuin1. Deficiency of sirtuin deacetylations is a consequence of reduced bioavailability of its cofactor nicotinamide adenine dinucleotide (NAD(+)). Uric acid-induced inflammation and oxidative stress consume NAD(+) and activation of the polyol pathway of fructose and uric acid synthesis also reduces the NAD(+)-to-NADH ratio. Variability in the compensatory regeneration of NAD(+) could result in variable recovery of sirtuin activity that may explain the inconsistent benefits of treatments directed to reduce uric acid in clinical trials. Here, we review the pathogenesis of the metabolic dysregulation driven by hyperuricemia and their potential relationship with sirtuin deficiency. In addition, we discuss therapeutic options directed to increase NAD(+) and sirtuins activity that may improve the adverse effects resulting from fructose and uric acid synthesis.
C1 [Rodriguez-Iturbe, Bernardo] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Nephrol & Mineral Metab, Mexico City, DF, Mexico.
   [Rodriguez-Iturbe, Bernardo; Garcia-Arroyo, Fernando E.; Sanchez-Lozada, Laura G.] Inst Nacl Cardiol Ignacio Chavez, Dept Cardiorenal Physiopathol, Mexico City, DF, Mexico.
   [Johnson, Richard J.] Univ Colorado, Div Renal Dis & Hypertens, Denver, CO 80202 USA.
   [Johnson, Richard J.] Rocky Mt Reg Vet Affairs Med Ctr, Kidney Dis Div, Denver, CO USA.
   [Lanaspa, Miguel A.] Oregon Hlth & Sci Univ, Div Nephrol & Hypertens, Portland, OR 97201 USA.
   [Nakagawa, Takahiko] Rakuwakai Otowa Hosp, Dept Nephrol, Kyoto, Japan.
C3 Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico; National Institute of Cardiology - Mexico; University of
   Colorado System; University of Colorado Denver; Oregon Health & Science
   University
RP Rodriguez-Iturbe, B (corresponding author), Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Nephrol & Mineral Metab, Mexico City, DF, Mexico.; Rodriguez-Iturbe, B; Sánchez-Lozada, LG (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Cardiorenal Physiopathol, Mexico City, DF, Mexico.
EM brodriguezIturbe@gmail.com
RI Sanchez-Lozada, Laura/AAS-2104-2021; Rodriguez-Iturbe,
   Bernardo/KFX-2910-2024; Lanaspa, Miguel/AAO-4971-2020
OI Sanchez-Lozada, Laura-Gabriela/0000-0003-0348-9617; Johnson,
   Richard/0000-0003-3312-8193; Garcia Arroyo, Fernando
   Enrique/0000-0003-1545-9765
FU National Institutes of Health [1RO1DK109408-01A1, RO1 DK108859-01];
   Veterans Affairs Merit [BXI01BX004511]; National Institute of Cardiology
   Ignacio Chavez; FONACYT, Venezuela [S1-2001001097, 2005000283]; IVIC,
   Venezuela [803, 1093]
FX GRANTS R. J. Johnson and M. A. Lanaspa were supported by National
   Institutes of Health Grants 1RO1DK109408-01A1 (to R. J.J.) , RO1
   DK108859-01 (to R.J.J.) , and Veterans Affairs Merit BXI01BX004511 (to
   R.J.J.) . Research in L. G. Sanchez-Lozada and F. E. Garcia-Arroyo was
   supported by Direct Expenditure Funds authorized to the Basic Research
   Subdirectorate of the National Institute of Cardiology Ignacio Chavez.
   Research in B. Rodriguez-Iturbe was supported by Grants S1-2001001097
   and 2005000283 (FONACYT, Venezuela) and by Grants 803 and 1093 (IVIC,
   Venezuela) .
CR Abdelmalek MF, 2012, HEPATOLOGY, V56, P952, DOI 10.1002/hep.25741
   Anderson KA, 2017, BBA-BIOENERGETICS, V1858, P991, DOI 10.1016/j.bbabio.2017.09.005
   Andres-Hernando A, 2021, JCI INSIGHT, V6, DOI 10.1172/jci.insight.140848
   Andres-Hernando A, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms14181
   [Anonymous], IN PLOS BIOL 4, P295, DOI [10.1371/journal.pbio.0040031, DOI 10.1371/JOURNAL.PBIO.0040031]
   Ardid-Ruiz A, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111757
   Badve SV, 2020, NEW ENGL J MED, V382, P2504, DOI 10.1056/NEJMoa1915833
   Bohata J, 2021, ARTHRITIS RES THER, V23, DOI 10.1186/s13075-021-02569-w
   Bordone L, 2006, PLOS BIOL, V4, P210, DOI 10.1371/journal.pbio.0040031
   Borghi C, 2020, EUR J INTERN MED, V80, P1, DOI 10.1016/j.ejim.2020.07.006
   Braidy N, 2019, ANTIOXID REDOX SIGN, V30, P251, DOI 10.1089/ars.2017.7269
   Brunet A, 2004, SCIENCE, V303, P2011, DOI 10.1126/science.1094637
   Chao YM, 2020, J BIOMED SCI, V27, DOI 10.1186/s12929-020-00660-z
   Chen YL, 2016, EXP THER MED, V12, P2241, DOI 10.3892/etm.2016.3605
   Cheng Y, 2016, BIOCHEM BIOPH RES CO, V474, P57, DOI 10.1016/j.bbrc.2016.04.065
   Cicerchi C, 2014, FASEB J, V28, P3339, DOI 10.1096/fj.13-243634
   Cimen H, 2010, BIOCHEMISTRY-US, V49, P304, DOI 10.1021/bi901627u
   COHEN AM, 1965, DIABETES, V14, P84, DOI 10.2337/diab.14.2.84
   Cristóbal-Garcia M, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/535686
   Curry AM, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.752117
   Cuyàs E, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00657
   de Gregorio E, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21113858
   Dellinger RW, 2017, NPJ AGING MECH DIS, V3, DOI 10.1038/s41514-017-0016-9
   Dikalova AE, 2020, CIRC RES, V126, P439, DOI 10.1161/CIRCRESAHA.119.315767
   Dikalova AE, 2017, CIRC RES, V121, P564, DOI 10.1161/CIRCRESAHA.117.310933
   Ding RB, 2017, INT J BIOL SCI, V13, P852, DOI 10.7150/ijbs.19370
   Doke T, 2018, METABOLISM, V85, P161, DOI 10.1016/j.metabol.2018.03.020
   Doria A, 2020, NEW ENGL J MED, V382, P2493, DOI 10.1056/NEJMoa1916624
   Drel VR, 2006, FREE RADICAL BIO MED, V40, P1454, DOI 10.1016/j.freeradbiomed.2005.12.034
   Fan H, 2013, KIDNEY INT, V83, P404, DOI 10.1038/ki.2012.394
   de Castro VMF, 2017, CLIN BIOCHEM, V50, P1289, DOI 10.1016/j.clinbiochem.2017.07.013
   Frescas D, 2005, J BIOL CHEM, V280, P20589, DOI 10.1074/jbc.M412357200
   Funk JA, 2013, TOXICOL APPL PHARM, V273, P345, DOI 10.1016/j.taap.2013.09.026
   Gaikwad A, 2001, J BIOL CHEM, V276, P22559, DOI 10.1074/jbc.M101053200
   García-Arroyo FE, 2019, FREE RADICAL BIO MED, V141, P182, DOI 10.1016/j.freeradbiomed.2019.06.016
   García-Arroyo FE, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0202901
   Garcia-ArroyoFE GonzagaG, 2019, FREE RADICAL BIO MED, V152, P865, DOI [10.1016/j. freeradbiomed.2019.06.016, DOI 10.1016/J.FREERADBIOMED.2019.06.016]
   Gerhart-Hines Z, 2007, EMBO J, V26, P1913, DOI 10.1038/sj.emboj.7601633
   Goldberg A, 2021, AM J NEPHROL, V52, P837, DOI 10.1159/000519491
   Grolla AA, 2020, J BIOL CHEM, V295, P3635, DOI 10.1074/jbc.RA119.010571
   Guo J, 2019, CIRC RES, V124, P1448, DOI 10.1161/CIRCRESAHA.118.314032
   Hallows WC, 2012, J BIOL CHEM, V287, P3850, DOI 10.1074/jbc.M111.317404
   Hao CM, 2010, J AM SOC NEPHROL, V21, P1620, DOI 10.1681/ASN.2010010046
   Hariharan N, 2010, CIRC RES, V107, P1470, DOI 10.1161/CIRCRESAHA.110.227371
   Hirschey MD, 2011, MOL CELL, V44, P177, DOI 10.1016/j.molcel.2011.07.019
   Hong Q, 2012, CELL CALCIUM, V51, P402, DOI 10.1016/j.ceca.2012.01.003
   Huang B, 2009, MOL CELL BIOL, V29, P1375, DOI 10.1128/MCB.01365-08
   Ishikawa K, 2015, SCI REP-UK, V5, DOI 10.1038/srep16386
   Jampoka Kanisa, 2018, Microrna, V7, P215, DOI 10.2174/2211536607666180531093302
   Johnson RJ, 2020, J INTERN MED, V287, P252, DOI 10.1111/joim.12993
   Johnson RJ, 2018, AM J KIDNEY DIS, V71, P851, DOI 10.1053/j.ajkd.2017.12.009
   Joosten LAB, 2020, NAT REV RHEUMATOL, V16, P75, DOI 10.1038/s41584-019-0334-3
   Kane AE, 2018, CIRC RES, V123, P868, DOI 10.1161/CIRCRESAHA.118.312498
   Katsyuba E, 2020, NAT METAB, V2, P9, DOI 10.1038/s42255-019-0161-5
   Kim SM, 2015, AM J PHYSIOL-RENAL, V308, pF993, DOI 10.1152/ajprenal.00637.2014
   Kimura Y, 2020, ARTERIOSCL THROM VAS, V40, P570, DOI 10.1161/ATVBAHA.119.313224
   King C, 2018, CONTRIB NEPHROL, V192, P88, DOI 10.1159/000484283
   Kitade M, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00187
   Klauser AS, 2019, JAMA CARDIOL, V4, P1019, DOI 10.1001/jamacardio.2019.3201
   Koh MY, 2012, TRENDS BIOCHEM SCI, V37, P364, DOI 10.1016/j.tibs.2012.06.004
   Kuang JY, 2017, DIABETES, V66, P1159, DOI 10.2337/db16-1225
   Lanaspa MA, 2018, P NATL ACAD SCI USA, V115, P3138, DOI 10.1073/pnas.1713837115
   Lanaspa MA, 2014, J AM SOC NEPHROL, V25, P2526, DOI 10.1681/ASN.2013080901
   Lanaspa MA, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3434
   Lanaspa MA, 2012, J BIOL CHEM, V287, P40732, DOI 10.1074/jbc.M112.399899
   Lanaspa MA, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0047948, 10.1371/journal.pone.0048801]
   Lee IH, 2008, P NATL ACAD SCI USA, V105, P3374, DOI 10.1073/pnas.0712145105
   Lee MCI, 2014, BIOCHEMISTRY-US, V53, P6615, DOI 10.1021/bi500582r
   Li HG, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20092155
   Li X, 2007, MOL CELL, V28, P91, DOI 10.1016/j.molcel.2007.07.032
   Li X, 2017, BMJ-BRIT MED J, V357, DOI 10.1136/bmj.j2376
   Liu GW, 2015, P NATL ACAD SCI USA, V112, pE957, DOI 10.1073/pnas.1420419112
   Liu L, 2018, CELL METAB, V27, P1067, DOI 10.1016/j.cmet.2018.03.018
   Liu TF, 2012, J BIOL CHEM, V287, P25758, DOI 10.1074/jbc.M112.362343
   Liu XM, 2018, RENAL FAILURE, V40, P289, DOI 10.1080/0886022X.2018.1456463
   Liu Y, 2008, NATURE, V456, P269, DOI 10.1038/nature07349
   Long JK, 2019, MOL MED, V25, DOI 10.1186/s10020-019-0085-2
   Mariani S, 2015, ENDOCRINE, V49, P711, DOI 10.1007/s12020-014-0465-x
   Martens CR, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-03421-7
   Martin AN, 2018, J IMMUNOL RES, V2018, DOI 10.1155/2018/2402593
   Martín-Guerrero SM, 2020, BIOCHEM J, V477, P4491, DOI 10.1042/BCJ20200525
   Martinon F, 2006, NATURE, V440, P237, DOI 10.1038/nature04516
   Mattagajasingh I, 2007, P NATL ACAD SCI USA, V104, P14855, DOI 10.1073/pnas.0704329104
   Mauer M, 2018, CONTRIB NEPHROL, V192, P103, DOI 10.1159/000484284
   Mehr AP, 2018, NAT MED, V24, P1351, DOI 10.1038/s41591-018-0138-z
   Mendes KL, 2017, CYTOKINE GROWTH F R, V38, P98, DOI 10.1016/j.cytogfr.2017.11.001
   Min ZY, 2019, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00783
   Miyazaki R, 2008, ARTERIOSCL THROM VAS, V28, P1263, DOI 10.1161/ATVBAHA.108.166991
   Morigi M, 2018, J AM SOC NEPHROL, V29, P1799, DOI 10.1681/ASN.2017111218
   Morikawa N, 2021, HYPERTENSION, V78, P1211, DOI 10.1161/HYPERTENSIONAHA.121.17555
   Nadtochiy SM, 2018, J MOL CELL CARDIOL, V121, P155, DOI 10.1016/j.yjmcc.2018.06.007
   Nakagawa T, 2020, J AM SOC NEPHROL, V31, P898, DOI 10.1681/ASN.2019101015
   Nemoto S, 2005, J BIOL CHEM, V280, P16456, DOI 10.1074/jbc.M501485200
   Nogueiras R, 2012, PHYSIOL REV, V92, P1479, DOI 10.1152/physrev.00022.2011
   Packer M, 2020, CIRC-HEART FAIL, V13, DOI 10.1161/CIRCHEARTFAILURE.120.007197
   Park TJ, 2017, SCIENCE, V356, P305, DOI 10.1126/science.aab3896
   Pfluger PT, 2008, P NATL ACAD SCI USA, V105, P9793, DOI 10.1073/pnas.0802917105
   Picard F, 2004, NATURE, V429, P771, DOI 10.1038/nature02583
   Ponugoti B, 2010, J BIOL CHEM, V285, P33959, DOI 10.1074/jbc.M110.122978
   Price NL, 2012, CELL METAB, V15, P675, DOI 10.1016/j.cmet.2012.04.003
   Purushotham A, 2009, CELL METAB, V9, P327, DOI 10.1016/j.cmet.2009.02.006
   Qiao YJ, 2018, TOXICOL LETT, V284, P37, DOI 10.1016/j.toxlet.2017.11.031
   Ralto KM, 2020, NAT REV NEPHROL, V16, P99, DOI 10.1038/s41581-019-0216-6
   Ramakrishnan G, 2014, J BIOL CHEM, V289, P6054, DOI 10.1074/jbc.M113.537266
   Rebollo A, 2014, BBA-MOL CELL BIOL L, V1841, P514, DOI 10.1016/j.bbalip.2014.01.002
   Ren ZN, 2022, ACTA PHARMACOL SIN, V43, P1264, DOI 10.1038/s41401-021-00744-y
   Rodrigo S, 2016, MOL NUTR FOOD RES, V60, P2700, DOI 10.1002/mnfr.201600193
   Rodriguez-Iturbe B, 2017, PHYSIOL REV, V97, P1127, DOI 10.1152/physrev.00031.2016
   Roncal CA, 2007, AM J PHYSIOL-RENAL, V292, pF116, DOI 10.1152/ajprenal.00160.2006
   Sampson AL, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009460.pub2
   Sánchez-Lozada LG, 2008, AM J PHYSIOL-RENAL, V295, pF1134, DOI 10.1152/ajprenal.00104.2008
   Sanchez-Lozada LG, 2020, AM J HYPERTENS, V33, P583, DOI 10.1093/ajh/hpaa044
   Sanchez-Lozada LG, 2019, J BIOL CHEM, V294, P4272, DOI 10.1074/jbc.RA118.006158
   Sánchez-Lozada LG, 2012, NEPHRON EXP NEPHROL, V121, pE71, DOI 10.1159/000345509
   Sánchez-Lozada LG, 2006, CURR OPIN NEPHROL HY, V15, P30, DOI 10.1097/01.mnh.0000199010.33929.7f
   Sasaki T, 2015, FRONT ENDOCRINOL, V6, DOI 10.3389/fendo.2015.00109
   Sato Y, 2019, NAT REV NEPHROL, V15, P767, DOI 10.1038/s41581-019-0174-z
   Schug TT, 2010, MOL CELL BIOL, V30, P4712, DOI 10.1128/MCB.00657-10
   Shinozaki S, 2014, SCI SIGNAL, V7, DOI 10.1126/scisignal.2005375
   Singh CK, 2018, ANTIOXID REDOX SIGN, V28, P643, DOI 10.1089/ars.2017.7290
   Singh M, 2010, J ALZHEIMERS DIS, V21, P229, DOI 10.3233/JAD-2010-091729
   Song ZL, 2017, J NEUROPHYSIOL, V117, P646, DOI 10.1152/jn.00781.2016
   Stromland O, 2019, BIOCHEM SOC T, V47, P119, DOI 10.1042/BST20180417
   Su XL, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0187550
   Sun K, 2020, J CELL MOL MED, V24, P7439, DOI 10.1111/jcmm.15365
   Sundaresan NR, 2011, SCI SIGNAL, V4, DOI 10.1126/scisignal.2001465
   Swe MT, 2019, CLIN SCI, V133, P2415, DOI 10.1042/CS20190863
   Tan SX, 2015, J BIOL CHEM, V290, P11337, DOI 10.1074/jbc.M114.623686
   Tarrago MG, 2018, CELL METAB, V27, P1081, DOI 10.1016/j.cmet.2018.03.016
   Tissenbaum HA, 2001, NATURE, V410, P227, DOI 10.1038/35065638
   Traba J, 2015, J CLIN INVEST, V125, P4592, DOI 10.1172/JCI83260
   Tran M, 2011, J CLIN INVEST, V121, P4003, DOI 10.1172/JCI58662
   Vachharajani VT, 2016, J IMMUNOL RES, V2016, DOI 10.1155/2016/8167273
   Vaupel P, 2021, J PHYSIOL-LONDON, V599, P1745, DOI 10.1113/JP278810
   Wang CH, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21155266
   Wang F, 2007, AGING CELL, V6, P505, DOI 10.1111/j.1474-9726.2007.00304.x
   Wang F, 2009, MOL BIOL CELL, V20, P801, DOI 10.1091/mbc.E08-06-0647
   Wang G, 2014, CELL, V158, P1324, DOI 10.1016/j.cell.2014.07.040
   Wang J, 2016, ENDOCRINE, V53, P443, DOI 10.1007/s12020-016-0896-7
   Wang YJ, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.755060
   Wen SJ, 2021, BIOCHEM BIOPH RES CO, V581, P6, DOI 10.1016/j.bbrc.2021.10.010
   Wu SS, 2023, CELL BIOL TOXICOL, V39, P237, DOI 10.1007/s10565-021-09649-2
   Wu T, 2014, ANN CLIN LAB SCI, V44, P410
   Wu YT, 2013, BBA-MOL BASIS DIS, V1832, P216, DOI 10.1016/j.bbadis.2012.10.002
   Xiong XW, 2017, J ENDOCRINOL, V233, P307, DOI 10.1530/JOE-17-0033
   Yang XD, 2010, MOL CELL BIOL, V30, P2170, DOI 10.1128/MCB.01343-09
   Yang XL, 2019, BIOMED PHARMACOTHER, V109, P1163, DOI 10.1016/j.biopha.2018.10.129
   Yang XY, 2017, J CLIN INVEST, V127, P1505, DOI 10.1172/JCI88574
   Yasuda I, 2021, J AM SOC NEPHROL, V32, P1355, DOI 10.1681/ASN.2020081188
   Yeung F, 2004, EMBO J, V23, P2369, DOI 10.1038/sj.emboj.7600244
   Yip K, 2020, CURR OPIN RHEUMATOL, V32, P71, DOI 10.1097/BOR.0000000000000679
   Yu MA, 2010, J HYPERTENS, V28, P1234, DOI 10.1097/HJH.0b013e328337da1d
   Yue Y, 2022, CAN J PHYSIOL PHARM, V100, P125, DOI 10.1139/cjpp-2021-0287
   Zhang B, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/3159801
   Zhang HL, 2020, J CELL MOL MED, V24, P8849, DOI 10.1111/jcmm.15523
   Zhang HH, 2015, EXP BIOL MED, V240, P557, DOI 10.1177/1535370214557218
   Zhang JN, 2009, J CLIN INVEST, V119, P3048, DOI 10.1172/JCI38902
   Zhang R, 2010, J BIOL CHEM, V285, P7097, DOI 10.1074/jbc.M109.038604
   Zhang XM, 2021, MOL MED REP, V24, DOI 10.3892/mmr.2021.12203
   Zheng JF, 2005, AM J PHYSIOL-RENAL, V288, pF387, DOI 10.1152/ajprenal.00436.2003
   Zheng ML, 2019, J CELL MOL MED, V23, P3995, DOI 10.1111/jcmm.14285
   Zhou S, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00748
   Zhou Y, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039738
NR 163
TC 8
Z9 8
U1 2
U2 17
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD MAY
PY 2022
VL 322
IS 5
BP R347
EP R359
DI 10.1152/ajpregu.00238.2021
PG 13
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 0N7JB
UT WOS:000783009200001
PM 35271385
OA Green Published
DA 2025-06-11
ER

PT J
AU Berdowska, I
   Matusiewicz, M
   Fecka, I
AF Berdowska, Izabela
   Matusiewicz, Malgorzata
   Fecka, Izabela
TI Methylglyoxal in Cardiometabolic Disorders: Routes Leading to Pathology
   Counterbalanced by Treatment Strategies
SO MOLECULES
LA English
DT Review
DE methylglyoxal; glyoxalase; advanced glycation end products; MG-H1;
   metabolic syndrome; insulin resistance; diabetes mellitus;
   cardiovascular disease; metformin; methylglyoxal scavengers
ID GLYCATION END-PRODUCTS; HUMAN SERUM-ALBUMIN; CORONARY-HEART-DISEASE;
   GLYOXALASE-I OVEREXPRESSION; SMOOTH-MUSCLE-CELLS; INCIDENT
   CARDIOVASCULAR-DISEASE; ALPHA-DICARBONYL COMPOUNDS; LOW-DENSITY
   LIPOPROTEINS; COA REDUCTASE INHIBITOR; MONOCYTIC THP-1 CELLS
AB Methylglyoxal (MGO) is the major compound belonging to reactive carbonyl species (RCS) responsible for the generation of advanced glycation end products (AGEs). Its upregulation, followed by deleterious effects at the cellular and systemic levels, is associated with metabolic disturbances (hyperglycemia/hyperinsulinemia/insulin resistance/hyperlipidemia/inflammatory processes/carbonyl stress/oxidative stress/hypoxia). Therefore, it is implicated in a variety of disorders, including metabolic syndrome, diabetes mellitus, and cardiovascular diseases. In this review, an interplay between pathways leading to MGO generation and scavenging is addressed in regard to this system's impairment in pathology. The issues associated with mechanistic MGO involvement in pathological processes, as well as the discussion on its possible causative role in cardiometabolic diseases, are enclosed. Finally, the main strategies aimed at MGO and its AGEs downregulation with respect to cardiometabolic disorders treatment are addressed. Potential glycation inhibitors and MGO scavengers are discussed, as well as the mechanisms of their action.
C1 [Berdowska, Izabela; Matusiewicz, Malgorzata] Wroclaw Med Univ, Dept Med Biochem, PL-50368 Wroclaw, Poland.
   [Fecka, Izabela] Wroclaw Med Univ, Dept Pharmacognosy & Herbal Med, Wroclaw, Poland.
C3 Wroclaw Medical University; Wroclaw Medical University
RP Berdowska, I (corresponding author), Wroclaw Med Univ, Dept Med Biochem, PL-50368 Wroclaw, Poland.; Fecka, I (corresponding author), Wroclaw Med Univ, Dept Pharmacognosy & Herbal Med, Wroclaw, Poland.
EM izabela.berdowska@umw.edu.pl; malgorzata.matusiewicz@umw.edu.pl;
   izabela.fecka@umw.edu.pl
RI Matusiewicz, Malgorzata/H-1081-2011; Berdowska, Izabela/AAZ-4016-2021;
   Fecka, Izabela/AAS-8974-2021
OI Fecka, Izabela/0000-0002-1139-4581; Matusiewicz,
   Malgorzata/0000-0003-4624-0109
CR Abordo EA, 1997, IMMUNOL LETT, V58, P139, DOI 10.1016/S0165-2478(97)00080-1
   Adeshara K, 2016, MOL BIOL REP, V43, P195, DOI 10.1007/s11033-016-3947-5
   Adeshara KA, 2018, INT J BIOL MACROMOL, V119, P1154, DOI 10.1016/j.ijbiomac.2018.08.026
   Ahmed LA, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0232413
   Ahmed N, 2005, J BIOL CHEM, V280, P5724, DOI 10.1074/jbc.M410973200
   Ahmed N, 2002, BIOCHEM J, V364, P1
   Ahmed N, 2003, INVEST OPHTH VIS SCI, V44, P5287, DOI 10.1167/iovs.03-0573
   Ahmed N, 2005, ANN NY ACAD SCI, V1043, P260, DOI 10.1196/annals.1333.031
   Amponsah-Offeh M, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12020281
   Arribas-Lorenzo G, 2010, J AGR FOOD CHEM, V58, P2966, DOI 10.1021/jf902815p
   Aviram M, 1998, ATHEROSCLEROSIS, V138, P271, DOI 10.1016/S0021-9150(98)00032-X
   Baba SP, 2009, DIABETES, V58, P2486, DOI 10.2337/db09-0375
   Baden T, 2008, BIOCHEM BIOPH RES CO, V373, P253, DOI 10.1016/j.bbrc.2008.06.023
   Baidoshvili A, 2004, ATHEROSCLEROSIS, V174, P287, DOI 10.1016/j.atherosclerosis.2004.02.012
   Bednarska K, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms241713168
   Bednarska K, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms221810026
   Beisswenger PJ, 1999, DIABETES, V48, P198, DOI 10.2337/diabetes.48.1.198
   Berge K, 2023, MED SCI SPORT EXER, V55, P1143, DOI 10.1249/MSS.0000000000003152
   Berlanga J, 2005, CLIN SCI, V109, P83, DOI 10.1042/CS20050026
   Bhuiyan MNI, 2017, BIOSCI BIOTECH BIOCH, V81, P882, DOI 10.1080/09168451.2017.1282805
   Bierhaus A, 2009, DIABETOLOGIA, V52, P2251, DOI 10.1007/s00125-009-1458-9
   Bierhaus A, 2012, NAT MED, V18, P926, DOI 10.1038/nm.2750
   Bo JS, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2029854
   Boekholdt SM, 2005, ARTERIOSCL THROM VAS, V25, P839, DOI 10.1161/01.ATV.0000157933.19424.b7
   Bolton WK, 2004, AM J NEPHROL, V24, P32, DOI 10.1159/000075627
   Booth AA, 1996, BIOCHEM BIOPH RES CO, V220, P113, DOI 10.1006/bbrc.1996.0366
   Borg DJ, 2016, GLYCOCONJUGATE J, V33, P653, DOI 10.1007/s10719-016-9691-1
   Bose T, 2013, ARCH BIOCHEM BIOPHYS, V529, P99, DOI 10.1016/j.abb.2012.12.001
   Braun JD, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-37937-1
   Brouwers O, 2010, DIABETOLOGIA, V53, P989, DOI 10.1007/s00125-010-1677-0
   Brouwers O, 2008, ANN NY ACAD SCI, V1126, P231, DOI 10.1196/annals.1433.017
   Brouwers O, 2016, GLYCOCONJUGATE J, V33, P627, DOI 10.1007/s10719-016-9681-3
   Brouwers O, 2014, DIABETOLOGIA, V57, P224, DOI 10.1007/s00125-013-3088-5
   Brouwers O, 2013, INT J MOL SCI, V14, P15724, DOI 10.3390/ijms140815724
   Brouwers O, 2011, J BIOL CHEM, V286, P1374, DOI 10.1074/jbc.M110.144097
   Brown BE, 2006, DIABETOLOGIA, V49, P775, DOI 10.1007/s00125-006-0137-3
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Brownlee M, 2005, DIABETES, V54, P1615, DOI 10.2337/diabetes.54.6.1615
   Busch M, 2006, AM J KIDNEY DIS, V48, P571, DOI 10.1053/j.ajkd.2006.07.009
   Chang TJ, 2005, FREE RADICAL BIO MED, V38, P286, DOI 10.1016/j.freeradbiomed.2004.10.034
   Chang TJ, 2011, FASEB J, V25, P1746, DOI 10.1096/fj.10-178053
   Chen HJC, 2015, CHEM RES TOXICOL, V28, P2377, DOI 10.1021/acs.chemrestox.5b00380
   Chou CK, 2015, J PHARMACEUT BIOMED, V116, P65, DOI 10.1016/j.jpba.2015.06.014
   CHRISTOPHER MM, 1995, METABOLISM, V44, P287, DOI 10.1016/0026-0495(95)90156-6
   Chu P, 2017, VASC PHARMACOL, V91, P26, DOI 10.1016/j.vph.2016.08.012
   Colzani M, 2016, CHEMMEDCHEM, V11, P1778, DOI 10.1002/cmdc.201500552
   Degen J, 2013, J AGR FOOD CHEM, V61, P10253, DOI 10.1021/jf304946p
   Degen J, 2012, J AGR FOOD CHEM, V60, P7071, DOI 10.1021/jf301306g
   Deng J., 2009, J. Chin. Physician, V11, P913, DOI DOI 10.3760/CMA.J.ISSN.1008-1372.2009.07.016
   Deng JX, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.637021
   Dhar A, 2011, DIABETES, V60, P899, DOI 10.2337/db10-0627
   Dhar A, 2010, BRIT J PHARMACOL, V161, P1843, DOI 10.1111/j.1476-5381.2010.01017.x
   Dhar A, 2010, BRIT J PHARMACOL, V159, P166, DOI 10.1111/j.1476-5381.2009.00469.x
   Dhar I, 2014, AM J HYPERTENS, V27, P308, DOI 10.1093/ajh/hpt281
   Dobler D, 2006, DIABETES, V55, P1961, DOI 10.2337/db05-1634
   Dolgacheva LP, 2019, J BIOENERG BIOMEMBR, V51, P175, DOI 10.1007/s10863-019-09798-4
   Dong LZ, 2024, CRIT REV FOOD SCI, V64, P9495, DOI 10.1080/10408398.2023.2213768
   Dong LZ, 2023, FOOD CHEM, V417, DOI 10.1016/j.foodchem.2023.135861
   Du XL, 2006, J CLIN INVEST, V116, P1071, DOI 10.1172/JCI23354
   Ebara T, 2000, J CLIN INVEST, V105, P1807, DOI 10.1172/JCI8283
   Engelbrecht B, 2014, HORM METAB RES, V46, P77, DOI 10.1055/s-0033-1357121
   Eringa EC, 2013, REV ENDOCR METAB DIS, V14, P39, DOI 10.1007/s11154-013-9239-7
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Fan X, 2003, ARCH BIOCHEM BIOPHYS, V409, P274, DOI 10.1016/S0003-9861(02)00599-4
   Fang X, 2021, MOL MED REP, V23, DOI 10.3892/mmr.2021.11840
   Faure P, 2005, DIABETES METAB, V31, P169, DOI 10.1016/S1262-3636(07)70183-0
   Fiory F, 2011, DIABETOLOGIA, V54, P2941, DOI 10.1007/s00125-011-2280-8
   Fishman SL, 2018, MOL MED, V24, DOI 10.1186/s10020-018-0060-3
   Fleming T, 2012, DIABETOLOGIA, V55, P1151, DOI 10.1007/s00125-012-2452-1
   Forbes JM, 2013, PHYSIOL REV, V93, P137, DOI 10.1152/physrev.00045.2011
   Fosmark DS, 2006, METABOLISM, V55, P232, DOI 10.1016/j.metabol.2005.08.017
   Francisco FA, 2018, EUR J NUTR, V57, P477, DOI 10.1007/s00394-016-1330-x
   Fukuda K, 2015, BIOCHEM BIOPH RES CO, V457, P23, DOI 10.1016/j.bbrc.2014.12.063
   Galligan JJ, 2018, P NATL ACAD SCI USA, V115, P9228, DOI 10.1073/pnas.1802901115
   Geoffrion M, 2014, PHYSIOL REP, V2, DOI 10.14814/phy2.12043
   Giacco F, 2010, CIRC RES, V107, P1058, DOI 10.1161/CIRCRESAHA.110.223545
   Godfrey L, 2014, NUTR DIABETES, V4, DOI 10.1038/nutd.2014.31
   Grosso G, 2017, AM J EPIDEMIOL, V185, P1304, DOI 10.1093/aje/kww207
   Gugliucci A, 2017, ADV NUTR, V8, P54, DOI 10.3945/an.116.013912
   Gugliucci A, 2016, MED HYPOTHESES, V93, P87, DOI 10.1016/j.mehy.2016.05.026
   Gul OO, 2010, METABOLISM, V59, P64, DOI 10.1016/j.metabol.2009.07.006
   Guo Q, 2009, J HYPERTENS, V27, P1664, DOI 10.1097/HJH.0b013e32832c419a
   Hagiwara S, 2009, METABOLISM, V58, P934, DOI 10.1016/j.metabol.2009.02.033
   Haller H, 2017, BIOMED RES INT, V2017, DOI 10.1155/2017/1909258
   Hanssen NMJ, 2021, DIABETES METAB, V47, DOI 10.1016/j.diabet.2020.02.002
   Hanssen NMJ, 2023, BIOMED PHARMACOTHER, V158, DOI 10.1016/j.biopha.2022.114211
   Hanssen NMJ, 2018, DIABETES CARE, V41, P1689, DOI 10.2337/dc18-0159
   Hanssen NMJ, 2017, DIABETES, V66, P2278, DOI 10.2337/db16-1578
   Hanssen NMJ, 2015, DIABETES, V64, P257, DOI 10.2337/db13-1864
   Hanssen NMJ, 2014, CARDIOVASC RES, V104, P160, DOI 10.1093/cvr/cvu189
   Hanssen NMJ, 2014, EUR HEART J, V35, P1137, DOI 10.1093/eurheartj/eht402
   Hanssen NMJ, 2013, J CLIN ENDOCR METAB, V98, pE1369, DOI 10.1210/jc.2013-1068
   HARDING JJ, 1989, ACTA OPHTHALMOL, V67, P518
   Hernandez-Castillo C, 2021, CHEM RES TOXICOL, V34, P2424, DOI 10.1021/acs.chemrestox.1c00221
   Hoffmann GR, 2009, DOSE-RESPONSE, V7, P1, DOI 10.2203/dose-response.08-023.Hoffmann
   Holovko OO, 2024, MOL CRYST LIQ CRYST, V768, P29, DOI 10.1080/15421406.2023.2238505
   Hüttl M, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9090803
   Huxley RR, 2003, EUR J CLIN NUTR, V57, P904, DOI 10.1038/sj.ejcn.1601624
   Hwang AR, 2018, KOREAN J PHYSIOL PHA, V22, P193
   Hwang AR, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0178278
   Indurthi VSK, 2014, EUR J PHARM SCI, V59, P58, DOI 10.1016/j.ejps.2014.04.002
   Irshad Z, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-44358-1
   Ishibashi Y, 2012, METABOLISM, V61, P1067, DOI 10.1016/j.metabol.2012.01.006
   Jack MM, 2011, DIABETOLOGIA, V54, P2174, DOI 10.1007/s00125-011-2196-3
   Jacobson R, 2014, THROMB RES, V134, P1350, DOI 10.1016/j.thromres.2014.09.038
   Jakus V, 1999, LIFE SCI, V65, P1991, DOI 10.1016/S0024-3205(99)00462-2
   Jang JH, 2017, J CELL MOL MED, V21, P2720, DOI 10.1111/jcmm.13188
   Jararnillo R, 2017, CHEM RES TOXICOL, V30, P689, DOI 10.1021/acs.chemrestox.6b00414
   Jia XM, 2007, MOL CELL BIOCHEM, V306, P133, DOI 10.1007/s11010-007-9563-x
   Jia XM, 2006, FASEB J, V20, P1555, DOI 10.1096/fj.05-5478fje
   Jiang WL, 2015, THROMB RES, V135, P459, DOI 10.1016/j.thromres.2014.12.016
   Jinnouchi Y, 2006, CLIN EXP MED, V6, P191, DOI 10.1007/s10238-006-0115-6
   Kalapos MP, 2013, DIABETES RES CLIN PR, V99, P260, DOI 10.1016/j.diabres.2012.11.003
   Kerkeni M, 2014, THROMB RES, V134, P633, DOI 10.1016/j.thromres.2014.07.008
   Kiho T, 2005, CLIN CHIM ACTA, V358, P139, DOI 10.1016/j.cccn.2005.02.012
   Kilhovd BK, 2009, ATHEROSCLEROSIS, V205, P590, DOI 10.1016/j.atherosclerosis.2008.12.041
   Kilhovd BK, 2005, ARTERIOSCL THROM VAS, V25, P815, DOI 10.1161/01.ATV.0000158380.44231.fe
   Kilhovd BK, 2003, METABOLISM, V52, P163, DOI 10.1053/meta.2003.50035
   Kim JH, 2018, J TOXICOL ENV HEAL A, V81, P266, DOI 10.1080/15287394.2018.1440185
   Kim Y, 2017, CLIN NUTR ESPEN, V20, P68, DOI 10.1016/j.clnesp.2017.03.004
   King AJF, 2012, BRIT J PHARMACOL, V166, P877, DOI 10.1111/j.1476-5381.2012.01911.x
   Kinsky OR, 2016, CHEM RES TOXICOL, V29, P227, DOI 10.1021/acs.chemrestox.5b00497
   Kirça M, 2022, J RECEPT SIG TRANSD, V42, P279, DOI 10.1080/10799893.2021.1918167
   Klöpfer A, 2011, J AGR FOOD CHEM, V59, P394, DOI 10.1021/jf103116c
   Kosmachevskaya OV, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10020253
   Koya D, 1997, J CLIN INVEST, V100, P115, DOI 10.1172/JCI119503
   Koyama H, 2014, ATHEROSCLEROSIS, V234, P329, DOI 10.1016/j.atherosclerosis.2014.03.025
   Kurosaki Y, 2013, J CLIN LAB ANAL, V27, P231, DOI 10.1002/jcla.21591
   Lankin V, 2014, MOL CELL BIOCHEM, V395, P241, DOI 10.1007/s11010-014-2131-2
   Lee GH, 1996, NATURE, V379, P632, DOI 10.1038/379632a0
   Lee JH, 2021, INT J BIOL MACROMOL, V187, P409, DOI 10.1016/j.ijbiomac.2021.07.058
   Lee JY, 2012, HUM MOL GENET, V21, P3215, DOI 10.1093/hmg/dds155
   Lee KY, 2018, VASC PHARMACOL, V102, P21, DOI 10.1016/j.vph.2018.01.001
   Lemieux I, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113501
   Li H, 2006, KIDNEY INT, V69, P388, DOI 10.1038/sj.ki.5000064
   Li WG, 2008, EXP BIOL MED, V233, P176, DOI 10.3181/0705-BC-131
   Libby P, 2021, NATURE, V592, P524, DOI 10.1038/s41586-021-03392-8
   Lieuw-a-Fa MLM, 2006, THROMB HAEMOSTASIS, V95, P320, DOI 10.1160/TH05-04-0248
   Lim HH, 2020, J FOOD COMPOS ANAL, V92, DOI 10.1016/j.jfca.2020.103584
   Liu GM, 2017, J AGR FOOD CHEM, V65, P2233, DOI 10.1021/acs.jafc.6b05811
   Liu HT, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046720
   Liu JH, 2011, CARDIOVASC RES, V92, P494, DOI 10.1093/cvr/cvr239
   Liu XM, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201601003
   Liu YQ, 2016, MOL PHARMACOL, V89, P313, DOI 10.1124/mol.115.102004
   LO TWC, 1994, J BIOL CHEM, V269, P32299
   Lu L, 2011, J ZHEJIANG UNIV-SC B, V12, P652, DOI 10.1631/jzus.B1101004
   Lu QG, 2019, BIOSCIENCE REP, V39, DOI 10.1042/BSR20181995
   Lu Y, 2014, LANCET, V383, P970, DOI 10.1016/S0140-6736(13)61836-X
   Contreras CL, 2017, FASEB J, V31
   LYLES GA, 1992, BIOCHEM PHARMACOL, V43, P1409, DOI 10.1016/0006-2952(92)90196-P
   Ma H, 2009, J CELL MOL MED, V13, P1751, DOI 10.1111/j.1582-4934.2008.00547.x
   Maessen DE, 2016, DIABETES, V65, P956, DOI 10.2337/db15-1390
   Mäkinen VP, 2014, PLOS GENET, V10, DOI 10.1371/journal.pgen.1004502
   Martins AMTBS, 2001, FEBS LETT, V499, P41, DOI 10.1016/S0014-5793(01)02519-4
   Marx N, 2004, DIABETES, V53, P2662, DOI 10.2337/diabetes.53.10.2662
   Masania J, 2016, GLYCOCONJUGATE J, V33, P581, DOI 10.1007/s10719-016-9692-0
   Matafome P, 2012, ARCH PHYSIOL BIOCHEM, V118, P58, DOI 10.3109/13813455.2012.658065
   Matafome P, 2017, MED RES REV, V37, P368, DOI 10.1002/med.21410
   McCarty MF, 2016, OPEN HEART, V3, DOI 10.1136/openhrt-2015-000365
   MCLELLAN AC, 1992, ANAL BIOCHEM, V206, P12, DOI 10.1016/S0003-2697(05)80004-1
   MCLELLAN AC, 1994, CLIN SCI, V87, P21, DOI 10.1042/cs0870021
   MCLELLAN AC, 1992, ANAL BIOCHEM, V206, P17, DOI 10.1016/S0003-2697(05)80005-3
   Metz TO, 2003, J BIOL CHEM, V278, P42012, DOI 10.1074/jbc.M304292200
   Mey JT, 2018, FRONT CARDIOVASC MED, V5, DOI 10.3389/fcvm.2018.00117
   Micek A, 2021, MOL NUTR FOOD RES, V65, DOI 10.1002/mnfr.202001019
   Miller A.G., 2009, Investig. Ophthalmol. Vis. Sci, V50
   Miller AG, 2010, DIABETES, V59, P3208, DOI 10.2337/db10-0552
   Minjares M, 2023, CELLS-BASEL, V12, DOI 10.3390/cells12091341
   Mirra P, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00046
   Mirra P, 2017, BBA-MOL BASIS DIS, V1863, P440, DOI 10.1016/j.bbadis.2016.11.018
   Miyata T, 2002, J AM SOC NEPHROL, V13, P2478, DOI 10.1097/01.ASN.0000032418.67267.F2
   Miyazawa N, 2010, FREE RADICAL RES, V44, P101, DOI 10.3109/10715760903321788
   Monnier VM, 2013, J DIABETES COMPLICAT, V27, P141, DOI 10.1016/j.jdiacomp.2012.10.004
   Morcos M, 2008, AGING CELL, V7, P260, DOI 10.1111/j.1474-9726.2008.00371.x
   Morgenstern J, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9100939
   Morgenstern J, 2017, J BIOL CHEM, V292, P3224, DOI 10.1074/jbc.M116.760132
   Mortera RR, 2019, FRONT BIOSCI-LANDMRK, V24, P186, DOI 10.2741/4713
   Mukohda M, 2013, J VET MED SCI, V75, P151, DOI 10.1292/jvms.12-0345
   Mukohda M, 2012, J PHARMACOL SCI, V120, P26, DOI 10.1254/jphs.12088FP
   Mukohda M, 2009, J PHARMACOL SCI, V109, P305, DOI 10.1254/jphs.08300FP
   Nangaku M, 2003, J AM SOC NEPHROL, V14, P1212, DOI 10.1097/01.ASN.0000062961.76776.C1
   Naomi ND, 2023, NUTR DIABETES, V13, DOI 10.1038/s41387-023-00237-3
   Natalucci S, 2003, EXP PHYSIOL, V88, P399, DOI 10.1113/eph8802565
   Natalucci S, 2000, EXP PHYSIOL, V85, P775
   Niedzielski M, 2020, BIOMED PHARMACOTHER, V129, DOI 10.1016/j.biopha.2020.110388
   Nigro C, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8070749
   Nigro C, 2019, BBA-MOL BASIS DIS, V1865, P73, DOI 10.1016/j.bbadis.2018.10.014
   Nigro C, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19020522
   Nigro C, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18010188
   Nigro C, 2014, DIABETOLOGIA, V57, P1485, DOI 10.1007/s00125-014-3243-7
   Nin JW, 2011, DIABETES CARE, V34, P442, DOI 10.2337/dc10-1087
   Oba T, 2012, ENVIRON TOXICOL PHAR, V34, P117, DOI 10.1016/j.etap.2012.03.007
   Ogawa S, 2010, HYPERTENSION, V56, P471, DOI 10.1161/HYPERTENSIONAHA.110.156786
   Oh S, 2019, J NUTR BIOCHEM, V72, DOI 10.1016/j.jnutbio.2019.04.001
   Oya T, 1999, J BIOL CHEM, V274, P18492, DOI 10.1074/jbc.274.26.18492
   Ozdemir AM, 2008, AM J NEPHROL, V28, P14, DOI 10.1159/000108757
   Papetti A, 2014, FOOD CHEM, V164, P259, DOI 10.1016/j.foodchem.2014.05.022
   Peters AS, 2019, VASA, V48, P186, DOI 10.1024/0301-1526/a000762
   Pfaff DH, 2017, J BIOL CHEM, V292, P685, DOI 10.1074/jbc.M116.743823
   PHILLIPS SA, 1993, BIOCHEM PHARMACOL, V46, P805, DOI 10.1016/0006-2952(93)90488-I
   PHILLIPS SA, 1993, EUR J BIOCHEM, V212, P101, DOI 10.1111/j.1432-1033.1993.tb17638.x
   Prantner D, 2021, J LEUKOCYTE BIOL, V109, P605, DOI 10.1002/JLB.3A0520-745RR
   Qais FA, 2021, INT J BIOL MACROMOL, V169, P143, DOI 10.1016/j.ijbiomac.2020.12.096
   Qiao YN, 2022, FRONT PHYSIOL, V13, DOI 10.3389/fphys.2022.931931
   Quade-Lyssy P, 2013, J LIPID RES, V54, P3052, DOI 10.1194/jlr.M038968
   Queisser MA, 2010, DIABETES, V59, P670, DOI 10.2337/db08-1565
   Rabbani N, 2021, NUTRIENTS, V13, DOI 10.3390/nu13072374
   Rabbani N, 2011, DIABETES, V60, P1973, DOI 10.2337/db11-0085
   Rabbani N, 2012, AMINO ACIDS, V42, P1133, DOI 10.1007/s00726-010-0783-0
   Rabbani N, 2010, DIABETES, V59, P1038, DOI 10.2337/db09-1455
   Folz R, 2021, DIABETOLOGIA, V64, P2131, DOI 10.1007/s00125-021-05539-8
   Rahbar S, 2000, CLIN CHIM ACTA, V301, P65, DOI 10.1016/S0009-8981(00)00327-2
   Ramis R, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8090344
   Rasheed S, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0190509
   Raval AD, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009403.pub2
   Ravi R, 2020, LIFE SCI, V246, DOI 10.1016/j.lfs.2020.117397
   Ravichandran M, 2018, CELL METAB, V27, P914, DOI 10.1016/j.cmet.2018.02.004
   Recabarren-Leiva D, 2021, INT J BIOL MACROMOL, V166, P1149, DOI 10.1016/j.ijbiomac.2020.10.270
   Ren J, 2021, NAT REV CARDIOL, V18, P499, DOI 10.1038/s41569-021-00511-w
   Ren XM, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-017-0531-9
   RENDELL M, 1986, J LAB CLIN MED, V108, P286
   Reyaz A, 2020, J DIABETES METAB DIS, V19, P515, DOI 10.1007/s40200-020-00543-y
   Ribeiro ML, 2006, GRAEF ARCH CLIN EXP, V244, P1591, DOI 10.1007/s00417-006-0318-2
   Riboulet-Chavey A, 2006, DIABETES, V55, P1289, DOI 10.2337/db05-0857
   Richarme G, 2017, SCIENCE, V357, P208, DOI 10.1126/science.aag1095
   Richarme G, 2015, J BIOL CHEM, V290, P1885, DOI 10.1074/jbc.M114.597815
   ROBERTS KA, 1990, EXP EYE RES, V50, P157, DOI 10.1016/0014-4835(90)90226-K
   Rodrigues T, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-01730-3
   Rodrigues T, 2013, ARCH PHYSIOL BIOCHEM, V119, P209, DOI 10.3109/13813455.2013.812121
   Ruggiero-Lopez D, 1999, BIOCHEM PHARMACOL, V58, P1765, DOI 10.1016/S0006-2952(99)00263-4
   Salazar J, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18147236
   Sambon M, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22115418
   Santos AN, 2017, MECH AGEING DEV, V166, P24, DOI 10.1016/j.mad.2017.07.009
   Schalkwijk CG, 2020, PHYSIOL REV, V100, P407, DOI 10.1152/physrev.00001.2019
   Schalkwijk CG, 2023, TRENDS ENDOCRIN MET, V34, P49, DOI 10.1016/j.tem.2022.11.004
   Schalkwijk CG, 2005, CLIN SCI, V109, P143, DOI 10.1042/CS20050025
   Scharnagl H, 2007, EXP CLIN ENDOCR DIAB, V115, P372, DOI 10.1055/s-2007-973830
   Scheijen Jean L J M, 2012, Exp Diabetes Res, V2012, P234812, DOI 10.1155/2012/234812
   Schumacher D, 2018, MOL METAB, V18, P143, DOI 10.1016/j.molmet.2018.09.005
   Schwedler SB, 2002, KIDNEY INT, V62, P301, DOI 10.1046/j.1523-1755.2002.00423.x
   Semba RD, 2009, J AM GERIATR SOC, V57, P1874, DOI 10.1111/j.1532-5415.2009.02438.x
   Semba RD, 2009, AGING CLIN EXP RES, V21, P182
   Semo D, 2023, J CLIN MED, V12, DOI 10.3390/jcm12041356
   Sena CM, 2012, PHARMACOL RES, V65, P497, DOI 10.1016/j.phrs.2012.03.004
   Shamsaldeen YA, 2016, CURR DRUG METAB, V17, P359, DOI 10.2174/1389200217666151222155216
   Shinohara M, 1998, J CLIN INVEST, V101, P1142, DOI 10.1172/JCI119885
   Smolders S, 2020, ACTA NEUROPATHOL COM, V8, DOI 10.1186/s40478-020-00935-4
   Sobal G, 2001, BIOCHEM PHARMACOL, V61, P373, DOI 10.1016/S0006-2952(00)00548-7
   Silva MS, 2013, BIOCHEM J, V453, P1, DOI 10.1042/BJ20121743
   Spadaccio C, 2014, THROMB RES, V133, P418, DOI 10.1016/j.thromres.2013.12.023
   Stratmann B, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23116186
   Stratmann B, 2016, SCI REP-UK, V6, DOI 10.1038/srep37737
   Su Y, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-134
   Subramanian U, 2017, GLYCOCONJUGATE J, V34, P255, DOI 10.1007/s10719-016-9760-5
   Synold T, 2008, CHEM RES TOXICOL, V21, P2148, DOI 10.1021/tx800224y
   Sztalryd C, 2017, BBA-MOL CELL BIOL L, V1862, P1221, DOI 10.1016/j.bbalip.2017.07.009
   Takahashi H, 2015, DIABETES, V64, P1262, DOI 10.2337/db14-0576
   THORNALLEY PJ, 1988, BIOCHEM J, V254, P751, DOI 10.1042/bj2540751
   Thornalley PJ, 2003, ARCH BIOCHEM BIOPHYS, V419, P31, DOI 10.1016/j.abb.2003.08.013
   Tikellis C, 2014, DIABETES, V63, P3915, DOI 10.2337/db13-0932
   Toprak C, 2019, EURASIAN J MED, V51, P285, DOI 10.5152/eurasianjmed.2019.18434
   Tsokanos FF, 2021, THROMB HAEMOSTASIS, V121, P1464, DOI 10.1055/s-0041-1726346
   Tusa I, 2023, CELLS-BASEL, V12, DOI 10.3390/cells12081154
   Unoki-Kubota H, 2010, PROTEIN PEPTIDE LETT, V17, P1177, DOI 10.2174/092986610791760423
   van den Eynde MDG, 2023, DIABETES OBES METAB, V25, P1280, DOI 10.1111/dom.14977
   Van den Eynde MDG, 2018, J NUTR, V148, P1911, DOI 10.1093/jn/nxy236
   van Eupen MGA, 2013, DIABETOLOGIA, V56, P1845, DOI 10.1007/s00125-013-2919-8
   VANBOEKEL MAM, 1992, BIOCHIM BIOPHYS ACTA, V1120, P201, DOI 10.1016/0167-4838(92)90270-N
   Varona JF, 2019, ARCH MED RES, V50, P20, DOI 10.1016/j.arcmed.2019.05.003
   Vasdev S, 1998, MOL CELL BIOCHEM, V181, P1, DOI 10.1023/A:1006844222963
   Voziyan PA, 2002, J BIOL CHEM, V277, P3397, DOI 10.1074/jbc.M109935200
   Vulesevic B, 2016, DIABETES, V65, P1699, DOI 10.2337/db15-0568
   Vulesevic B, 2014, CARDIOVASC RES, V101, P306, DOI 10.1093/cvr/cvt259
   Wang FL, 2021, FRONT CELL DEV BIOL, V9, DOI 10.3389/fcell.2021.742483
   Wang G, 2022, CELL DEATH DIS, V13, DOI 10.1038/s41419-021-04478-x
   Wang HL, 2023, SIGNAL TRANSDUCT TAR, V8, DOI 10.1038/s41392-023-01347-1
   Wang H, 2006, LIFE SCI, V79, P2448, DOI 10.1016/j.lfs.2006.08.009
   Wang H, 2009, BIOCHEM PHARMACOL, V77, P1709, DOI 10.1016/j.bcp.2009.02.024
   Wang T, 2015, BIOORG MED CHEM LETT, V25, P4881, DOI 10.1016/j.bmcl.2015.06.013
   Wang X, 2014, BRIT J NUTR, V111, P1, DOI 10.1017/S000711451300278X
   Wang XX, 2008, J HYPERTENS, V26, P765, DOI 10.1097/HJH.0b013e3282f4a13c
   Wang XX, 2007, AM J HYPERTENS, V20, P629, DOI 10.1016/j.amjhyper.2006.12.003
   Wang XX, 2005, J HYPERTENS, V23, P1565, DOI 10.1097/01.hjh.0000173778.85233.1b
   Wang XX, 2004, KIDNEY INT, V66, P2315, DOI 10.1111/j.1523-1755.2004.66034.x
   Wang YH, 2019, AM J PHYSIOL-CELL PH, V317, pC68, DOI 10.1152/ajpcell.00117.2018
   Watanabe H, 2000, BIOCHEM J, V349, P813, DOI 10.1042/bj3490813
   Westwood ME, 1996, IMMUNOL LETT, V50, P17, DOI 10.1016/0165-2478(96)02496-0
   Wu LY, 2002, HYPERTENSION, V39, P809, DOI 10.1161/hy0302.105207
   Yamagishi SI, 2008, EXPERT OPIN INV DRUG, V17, P983, DOI 10.1517/13543784.17.7.983 
   Yoon SJ, 2009, EXP MOL MED, V41, P802, DOI 10.3858/emm.2009.41.11.086
   Zemva J, 2017, REDOX BIOL, V13, P674, DOI 10.1016/j.redox.2017.08.007
   Zhang XD, 2023, CLIN SCI, V137, P697, DOI 10.1042/CS20220753
   Zhang XM, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-87561-9
   Zhang XY, 2015, SCI CHINA LIFE SCI, V58, P101, DOI 10.1007/s11427-014-4792-1
   Zheng J, 2021, TRENDS FOOD SCI TECH, V107, P201, DOI 10.1016/j.tifs.2020.10.031
   Zhou YJ, 2018, CELL PHYSIOL BIOCHEM, V51, P1119, DOI 10.1159/000495491
NR 296
TC 7
Z9 7
U1 7
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD DEC
PY 2023
VL 28
IS 23
AR 7742
DI 10.3390/molecules28237742
PG 53
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA AE5A4
UT WOS:001116788500001
PM 38067472
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Wahba, NS
   Ghareib, SA
   Abdel-Ghany, RH
   Abdel-Aal, M
   Alsemeh, AE
AF Wahba, Nehal S.
   Ghareib, Salah A.
   Abdel-Ghany, Rasha H.
   Abdel-Aal, Mohamed
   Alsemeh, Amira E.
TI Vitamin D3 potentiates the nephroprotective effects of metformin in a
   rat model of metabolic syndrome: role of AMPK/SIRT1 activation and DPP-4
   inhibition
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE metabolic syndrome; nephropathy; metformin; vitamin D3; AMPK/SIRT1;
   DPP-4; RAAS
ID GLYCATION END-PRODUCTS; DENSITY-LIPOPROTEIN CHOLESTEROL;
   RENIN-ANGIOTENSIN SYSTEM; GLUCAGON-LIKE PEPTIDE-1; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; D SUPPLEMENTATION; OXIDATIVE STRESS; HIGH GLUCOSE;
   URIC-ACID
AB The current study aimed to investigate the molecular mechanisms of metformin and vitamin D3-induced nephroprotection in a metabolic syndrome (MetS) rat model, evaluating the capacity of vitamin D3 to potentiate metformin action. MetS was induced by 10% fructose in drinking water and 3% salt in the diet. After 6 weeks, serum lipid profile and uric acid were measured, an oral glucose tolerance test (OGTT) was performed, and kidney function was investigated. In conjunction with the same concentrations of fructose and salt feeding, MetS rats with significant weight gain, dyslipidemia, hyperuricemia, and dysglycemia were treated orally with metformin (200 mg/kg), vitamin D3 (10 lg/kg), or both daily for 6 weeks. At the end of the study period, anthropometrical parameters were recorded, OGTT was reperformed, urine and blood samples were collected, and tissue samples were harvested at sacrifice. MetS rats showed dramatically declined renal function, enhanced intrarenal oxidative stress and inflammation, and extravagant renal histopathological damage with interstitial fibrosis. Metformin and vitamin D3 significantly reversed all the aforementioned deleterious effects in MetS rats. The study has verified the nephroprotective effects of metformin and vitamin D3 in MetS, accentuating the critical role of AMP-activated protein kinase/sirtuin-1 activation and dipeptidyl peptidase-4 inhibition. Given the synergistic effects of the combination, vitamin D3 is worth being investigated as an additional therapeutic agent for preventing MetS-induced nephropathy.
C1 [Wahba, Nehal S.; Ghareib, Salah A.; Abdel-Ghany, Rasha H.; Abdel-Aal, Mohamed] Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig, Egypt.
   [Alsemeh, Amira E.] Zagazig Univ, Fac Human Med, Dept Anat & Embryol, Zagazig, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Egyptian Knowledge
   Bank (EKB); Zagazig University
RP Wahba, NS (corresponding author), Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig, Egypt.
EM nehalsamirwahba@gmail.com
RI abdalaal, mohamed/JGD-9871-2023; Atteiah, salah/I-1537-2012; Alsemeh,
   Amira/LWH-9728-2024; Wahba, Nehal/AAX-3271-2021
OI Wahba, Nehal/0000-0002-8637-9204; Ghareib, Salah/0009-0005-5718-321X
CR Abdallah HM, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1340-5
   Adhikary L, 2004, DIABETOLOGIA, V47, P1210, DOI 10.1007/s00125-004-1437-0
   AEBI H, 1984, METHOD ENZYMOL, V105, P121
   Alkharfy KM, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-113
   Anderson KA, 2017, BBA-BIOENERGETICS, V1858, P991, DOI 10.1016/j.bbabio.2017.09.005
   Andrews ES, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0205831
   [Anonymous], 2017, WORLD CLIN J MED SCI
   Ayina CNA, 2016, LIPIDS HEALTH DIS, V15, DOI 10.1186/s12944-016-0264-x
   Bakhshalizadeh S, 2018, CELL BIOCHEM FUNCT, V36, P183, DOI 10.1002/cbf.3330
   Baldwin W, 2011, DIABETES, V60, P1258, DOI 10.2337/db10-0916
   Beraldo JI, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20081940
   Bidwell AJ, 2017, NUTRIENTS, V9, DOI 10.3390/nu9060549
   Bosi PL, 2008, BRAZ ARCH BIOL TECHN, V51, P295, DOI 10.1590/S1516-89132008000200009
   Cai XL, 2019, DIABETOL METAB SYNDR, V11, DOI 10.1186/s13098-019-0418-x
   Cantó C, 2012, PHARMACOL REV, V64, P166, DOI 10.1124/pr.110.003905
   Chen I-Chun, 2018, Oncotarget, V9, P9285, DOI 10.18632/oncotarget.24290
   Chen XR, 2004, J IMMUNOASS IMMUNOCH, V25, P81, DOI 10.1081/IAS-120027228
   Cheng CLL, 2012, CLIN INVEST MED, V35, pE282
   Corremans R, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20010042
   Crawford SO, 2010, INT J EPIDEMIOL, V39, P1647, DOI 10.1093/ije/dyq126
   Crofts C. A. P., 2015, DIABESITY, V1, P34, DOI [DOI 10.15562/DIABESITY.2015.19, 10.15562/diabesity.2015.19]
   Cuyàs E, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00657
   De Broe ME, 2018, NEPHRON, V138, P261, DOI 10.1159/000481951
   Dikalov SI, 2013, ANTIOXID REDOX SIGN, V19, P1085, DOI 10.1089/ars.2012.4604
   Drury RA., 1980, Carletons Histological Techniques, V5th, P125
   Duong JK, 2013, CLIN PHARMACOKINET, V52, P373, DOI 10.1007/s40262-013-0046-9
   El Talees AA, 2018, BENHA MED J, V35, P67, DOI 10.4103/bmfj.bmfj_3_17
   Farah LXS, 2016, AM J PHYSIOL-RENAL, V310, pF123, DOI 10.1152/ajprenal.00394.2015
   FAWCETT JK, 1960, J CLIN PATHOL, V13, P156, DOI 10.1136/jcp.13.2.156
   Fish R., 2011, Anesthesia and analgesia in laboratory animals
   FOSSATI P, 1980, CLIN CHEM, V26, P227
   FOSSATI P, 1982, CLIN CHEM, V28, P2077
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Gallagher EJ, 2010, MT SINAI J MED, V77, P511, DOI 10.1002/msj.20212
   Giannarelli R, 2003, DIABETES METAB, V29, pS28
   Gong L, 2012, PHARMACOGENET GENOM, V22, P820, DOI 10.1097/FPC.0b013e3283559b22
   Greco EA, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071506
   GROVE TH, 1979, CLIN CHEM, V25, P560
   Gu JH, 2016, KIDNEY BLOOD PRESS R, V41, P848, DOI 10.1159/000452588
   Han TS, 2017, HYPERTENSION, V70, P703, DOI [10.1161/HYPERTENSIONAHA.117.09508, 10.1161/hypertensionaha.117.09508]
   He L, 2009, CELL, V137, P635, DOI 10.1016/j.cell.2009.03.016
   Henry RJ, 1974, CLIN CHEM PRINCIPLES
   Hernández JS, 2014, J CELL MOL MED, V18, P709, DOI 10.1111/jcmm.12220
   Hinke SA, 2002, BIOCHEM BIOPH RES CO, V291, P1302, DOI 10.1006/bbrc.2002.6607
   Huang XZ, 2014, J CELL BIOCHEM, V115, P996, DOI 10.1002/jcb.24748
   Hussain A, 2018, CUREUS J MED SCIENCE, V10, DOI 10.7759/cureus.3158
   Imano H., 2014, Circulation, V129, pAP455, DOI [10.1161/circ.129.suppl_1.p455, DOI 10.1161/CIRC.129.SUPPL_1.P455]
   Ishibashi Y, 2012, HORM METAB RES, V44, P891, DOI 10.1055/s-0032-1321878
   Jeon SM, 2018, EXP MOL MED, V50, DOI 10.1038/s12276-018-0038-9
   Jin J, 2017, KOREAN J INTERN MED, V32, P314, DOI 10.3904/kjim.2015.394
   Johnson RJ, 2013, DIABETES, V62, P3307, DOI 10.2337/db12-1814
   Kabel A.M., 2016, IJPSR, V2, P103, DOI [10.25141/2471-6782-2016-2.0103, DOI 10.25141/2471-6782-2016-2.0103, 10.25141/ 2471-6782-2016-2.0103]
   Kahn SE, 2003, DIABETOLOGIA, V46, P3, DOI 10.1007/s00125-002-1009-0
   Kanauchi M, 2002, DIABETES CARE, V25, P1891, DOI 10.2337/diacare.25.10.1891
   Kaplan A., 1984, ClinChem, P436
   Kiernan J.A., 1999, SHOCK, V12, P479, DOI DOI 10.1097/00024382-199912000-00012
   Kirpichnikov D, 2002, ANN INTERN MED, V137, P25, DOI 10.7326/0003-4819-137-1-200207020-00009
   Lanaspa MA, 2018, P NATL ACAD SCI USA, V115, P3138, DOI 10.1073/pnas.1713837115
   Lee YS, 2016, MEDIAT INFLAMM, V2016, DOI 10.1155/2016/3094642
   Li CG, 2013, CURR OPIN RHEUMATOL, V25, P210, DOI 10.1097/BOR.0b013e32835d951e
   Li Jian-Mei, 2008, Chinese Journal of Natural Medicines, V6, P466, DOI 10.3724/SP.J.1009.2008.00466
   Lindsay JR, 2005, DIABETIC MED, V22, P654, DOI 10.1111/j.1464-5491.2005.01461.x
   Liu J, 2019, BIOSCIENCE REP, V39, DOI 10.1042/BSR20181994
   Luo H, 2015, J AM HEART ASSOC, V4, DOI 10.1161/JAHA.114.001559
   Manna P, 2017, ARCH BIOCHEM BIOPHYS, V615, P22, DOI 10.1016/j.abb.2017.01.002
   Mannucci E, 2001, DIABETES CARE, V24, P489, DOI 10.2337/diacare.24.3.489
   Marampon F, 2013, J HYPERTENS, V31, P1972, DOI 10.1097/HJH.0b013e3283638b32
   Martin SS, 2008, J AM COLL CARDIOL, V52, P1201, DOI 10.1016/j.jacc.2008.05.060
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   MEIATTINI F, 1978, CLIN CHEM, V24, P2161
   Migoya EM, 2007, DIABETES, V56, pA74
   Naini AE, 2016, J RES MED SCI, V21, DOI 10.4103/1735-1995.175144
   Nakashima A, 2016, WORLD J DIABETES, V7, P89, DOI 10.4239/wjd.v7.i5.89
   Nelson LE, 2012, AM J PHYSIOL-CELL PH, V303, pC4, DOI 10.1152/ajpcell.00296.2011
   Novelli ELB, 2007, LAB ANIM-UK, V41, P111, DOI 10.1258/002367707779399518
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   Ohno T, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0124081
   Okabe K, 2019, J BIOMED SCI, V26, DOI 10.1186/s12929-019-0527-8
   Omidian M, 2019, DIABETOL METAB SYNDR, V11, DOI 10.1186/s13098-019-0479-x
   Pan QJ, 2020, AGING-US, V12, P8742, DOI 10.18632/aging.103095
   Park JE, 2018, J OBES METAB SYNDR, V27, P223, DOI 10.7570/jomes.2018.27.4.223
   Patanè G, 2000, DIABETES, V49, P735, DOI 10.2337/diabetes.49.5.735
   Perfil'ev VY, 2017, REGUL MECH BIOSYST, V8, P644, DOI 10.15421/021799
   Perlstein TS, 2004, KIDNEY INT, V66, P1465, DOI 10.1111/j.1523-1755.2004.00909.x
   Piwkowska A, 2010, BIOCHEM BIOPH RES CO, V393, P268, DOI 10.1016/j.bbrc.2010.01.119
   Pollak N, 2007, BIOCHEM J, V402, P205, DOI 10.1042/BJ20061638
   Porsti IH, 2008, KIDNEY INT, V74, P1371, DOI 10.1038/ki.2008.424
   Prietl B, 2013, NUTRIENTS, V5, P2502, DOI 10.3390/nu5072502
   Raimundo M, 2011, CARDIOL RES PRACT, V2011, DOI 10.4061/2011/747861
   Rhee CM, 2017, NEPHRON, V135, P147, DOI 10.1159/000450862
   Rosset R, 2016, CURR HYPERTENS REP, V18, DOI 10.1007/s11906-016-0652-7
   Sánchez-Lozada LG, 2008, AM J PHYSIOL-RENAL, V295, pF1134, DOI 10.1152/ajprenal.00104.2008
   Sanchez-Lozada LG, 2007, AM J PHYSIOL-RENAL, V292, pF423, DOI 10.1152/ajprenal.00124.2006
   Sanit J, 2019, EXP THER MED, V18, P1701, DOI 10.3892/etm.2019.7763
   Schrauben SJ, 2019, BMC NEPHROL, V20, DOI 10.1186/s12882-019-1220-6
   Shanik MH, 2008, DIABETES CARE, V31, pS262, DOI 10.2337/dc08-s264
   Shin Jang-Woo, 2010, [Journal of Korean Medicine, 대한한의학회지], V31, P1
   Skov J, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00023
   Uribarri J, 2011, DIABETES CARE, V34, P1610, DOI 10.2337/dc11-0091
   Velimirovic M, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/3273654
   Wan C, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/7813072
   Wang WN, 2019, J MOL MED, V97, P291, DOI 10.1007/s00109-019-01743-7
   Wu AHB., 2006, Tietz clinical guide to laboratory tests-E-book, V4
   Wu C. -C., 2017, SIVAKUMAR GOWDER, DOI [10.5772/64517, DOI 10.5772/64517]
   Yamagishi S, 2010, OXID MED CELL LONGEV, V3, P101, DOI 10.4161/oxim.3.2.11148
   Yang KK, 2016, J RENIN-ANGIO-ALDO S, V17, DOI 10.1177/1470320316673231
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI13505
   Zhu XX, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027081
NR 108
TC 6
Z9 7
U1 0
U2 9
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD JUN
PY 2021
VL 99
IS 6
BP 687
EP 699
DI 10.1139/cjpp-2020-0435
PG 13
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA SW4HR
UT WOS:000664477100014
PM 33108744
DA 2025-06-11
ER

PT J
AU Alemany, M
AF Alemany, Maria
TI Relationship between energy dense diets and white adipose tissue
   inflammation in metabolic syndrome
SO NUTRITION RESEARCH
LA English
DT Review
DE Metabolic syndrome; Inflammation; Endoplasmic reticulum stress;
   Ponderostat; Insulin resistance; White adipose tissue
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; LOW-GRADE
   INFLAMMATION; INSULIN-RESISTANCE; BODY-WEIGHT; ENDOTHELIAL DYSFUNCTION;
   OLEOYL-ESTRONE; BLOOD-FLOW; SUBCLINICAL INFLAMMATION; MACROPHAGE
   INFILTRATION
AB Metabolic syndrome (MS) is a widespread pathologic state that manifests as multiple intertwined diseases affecting the entire body. This review analyzes the contribution of adipose tissue inflammation to its development. The main factor in the appearance of MS is an excess of dietary energy (largely fats), eliciting insulin resistance and creating the problem of excess energy disposal. Under these conditions, amino acid catabolism is diminished, which indirectly alters the production of nitric oxide and affects blood flow regulation. The oxidation of nitric oxide to nitrite and nitrate affects microbiota composition and functions. Adipose tissue cannot incorporate excessive nutrients after cell enlargement and loss of function. Tissue damage is a form of aggression, and the response is proinflammatory cytokine release. Cytokines favor the massive penetration of immune system cells, such as macrophages, which unsuccessfully try to fight an elusive danger for which they are not prepared. The consequence is low-level maintenance of the inflammatory state, which affects endoplasmic reticulum function and the endothelial response to excess regulatory mechanisms affecting blood flow and substrate/oxygen supply. When inflammation becomes chronic, the pathologic consequences are disseminated throughout the body because unused substrates and signals from adipose tissue affect energy partitioning and organ function. This maintenance of an unbalanced state ultimately results in the establishment of MS and associated pathologies. New research should focus on identifying ways to disarm the inflammatory response of adipose tissue when the dangers of dietary excess have already been controlled. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Alemany, Maria] Univ Barcelona, Fac Biol, Dept Nutr & Food Sci, E-08028 Barcelona, Spain.
   [Alemany, Maria] Inst Hlth Carlos III, CIBER Obes & Nutr, Madrid, Spain.
C3 University of Barcelona; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN
RP Alemany, M (corresponding author), Univ Barcelona, Fac Biol, Dept Nutr & Food Sci, 643 Av Diagonal, E-08028 Barcelona, Spain.
EM malemany@ub.edu
RI Alemany, Maria/H-5224-2011
OI Alemany, Maria/0000-0002-9783-8293
FU Plan Nacional de Investigacion en Biomedicina of the Government of Spain
   [SAF2009-11739]
FX This work was supported by grant SAF2009-11739 from the Plan Nacional de
   Investigacion en Biomedicina of the Government of Spain.
CR Adán C, 1999, INT J OBESITY, V23, P366, DOI 10.1038/sj.ijo.0800828
   Alemany M., 2012, FRONT ENDOCRINOL, V3
   Alemany M, 2012, J ENDOCRINOL METAB, V2, P155, DOI 10.4021/jem116w
   Alemany M, 2012, HORM-INT J ENDOCRINO, V11, P272, DOI 10.14310/horm.2002.1356
   Alemany M, 2012, NUTR RES REV, V25, P18, DOI 10.1017/S0954422411000163
   Alemany M, 2011, J CLIN ENDOCR METAB, V96, P66, DOI 10.1210/jc.2010-2541
   Anelli T, 2002, EMBO J, V21, P835, DOI 10.1093/emboj/21.4.835
   Apovian CM, 2008, ARTERIOSCL THROM VAS, V28, P1654, DOI 10.1161/ATVBAHA.108.170316
   BAILEY CJ, 1985, NUTR RES, V5, P1003, DOI 10.1016/S0271-5317(85)80114-7
   Balistreri CR, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/802078
   BARBER T, 1985, BIOCHEM J, V230, P675, DOI 10.1042/bj2300675
   Barbosa-Tessmann IP, 2000, J BIOL CHEM, V275, P26976
   BARER GR, 1952, BRIT J EXP PATHOL, V33, P123
   Barnes PJ, 2006, BRIT J PHARMACOL, V148, P245, DOI 10.1038/sj.bjp.0706736
   Ben Lazreg T, 2007, BIOL RHYTHM RES, V38, P9, DOI 10.1080/09291010600831380
   Bi MX, 2005, EMBO J, V24, P3470, DOI 10.1038/sj.emboj.7600777
   Björntorp P, 1999, ANN NY ACAD SCI, V892, P297, DOI 10.1111/j.1749-6632.1999.tb07803.x
   Boden G, 2009, DIABETES, V58, P518, DOI 10.2337/db08-1746
   Boivin MA, 2007, AM J PHYSIOL-GASTR L, V292, pG590, DOI 10.1152/ajpgi.00252.2006
   BRADLEY P, 1978, AM J CLIN NUTR, V31, P1975, DOI 10.1093/ajcn/31.11.1975
   Buijs RM, 2006, J NEUROENDOCRINOL, V18, P715, DOI 10.1111/j.1365-2826.2006.01456.x
   Cabanac M, 2001, INT J OBESITY, V25, pS7, DOI 10.1038/sj.ijo.0801904
   Calabro P, 2005, J AM COLL CARDIOL, V46, P1112, DOI 10.1016/j.jacc.2005.06.017
   Cancello R, 2006, BJOG-INT J OBSTET GY, V113, P1141, DOI 10.1111/j.1471-0528.2006.01004.x
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Canova NK, 2008, TOXICOL MECH METHOD, V18, P63, DOI 10.1080/15376510701738421
   Celsus AC, 1722, AULUS CORNELIUM CELS, P1
   Cheung O, 2008, SEMIN LIVER DIS, V28, P351, DOI 10.1055/s-0028-1091979
   Chow L, 2010, METABOLISM, V59, P70, DOI 10.1016/j.metabol.2009.07.009
   Coleman RA, 2004, PROG LIPID RES, V43, P134, DOI 10.1016/S0163-7827(03)00051-1
   Conde J, 2011, BIOFACTORS, V37, P413, DOI 10.1002/biof.185
   Cori CF, 1927, J BIOL CHEM, V74
   Cornier MA, 2008, ENDOCR REV, V29, P777, DOI 10.1210/er.2008-0024
   Creely SJ, 2007, AM J PHYSIOL-ENDOC M, V292, pE740, DOI 10.1152/ajpendo.00302.2006
   D'Antonio M, 2009, J NEUROSCI RES, V87, P3241, DOI 10.1002/jnr.22066
   Das UN, 2002, PROSTAG LEUKOTR ESS, V67, P1, DOI 10.1054/plef.2002.0374
   De Pauw A, 2009, AM J PATHOL, V175, P927, DOI 10.2353/ajpath.2009.081155
   Degawa-Yamauchi M, 2005, OBES RES, V13, P662, DOI 10.1038/oby.2005.74
   Delaporte E, 2008, ANN DERMATOL VENER, V135, pS269, DOI 10.1016/S0151-9638(08)70547-7
   Delzenne NM, 2010, INT DAIRY J, V20, P277, DOI 10.1016/j.idairyj.2009.11.006
   Deng ZB, 2009, DIABETES, V58, P2498, DOI 10.2337/db09-0216
   Desroches S, 2007, APPL PHYSIOL NUTR ME, V32, P23, DOI 10.1139/h06-095
   DIGIROLAMO M, 1992, FASEB J, V6, P2405, DOI 10.1096/fasebj.6.7.1563593
   Drapeau V, 2004, AM J CLIN NUTR, V80, P29
   Dulloo AG, 2001, INT J OBESITY, V25, pS22, DOI 10.1038/sj.ijo.0801907
   Duncan B B, 2001, Sao Paulo Med J, V119, P122
   EATON SB, 1992, LIPIDS, V27, P814, DOI 10.1007/BF02535856
   EATON SB, 1985, NEW ENGL J MED, V312, P283, DOI 10.1056/NEJM198501313120505
   Eming SA, 2007, J INVEST DERMATOL, V127, P514, DOI 10.1038/sj.jid.5700701
   Eringa EC, 2007, MICROCIRCULATION, V14, P389, DOI 10.1080/10739680701303584
   ESTEVE M, 1993, BIOCHEM MOL BIOL INT, V29, P1069
   Fain JN, 2006, VITAM HORM, V74, P443, DOI 10.1016/S0083-6729(06)74018-3
   Fargnoli JL, 2010, EUR J ENDOCRINOL, V162, P281, DOI 10.1530/EJE-09-0555
   FELIG P, 1969, J CLIN INVEST, V48, P584, DOI 10.1172/JCI106017
   Ferrante AW, 2007, J INTERN MED, V262, P408, DOI 10.1111/j.1365-2796.2007.01852.x
   Flamment M, 2010, CURR OPIN LIPIDOL, V21, P239, DOI 10.1097/MOL.0b013e3283395e5c
   Fleming ME, 2005, COLORECTAL DIS, V7, P128, DOI 10.1111/j.1463-1318.2004.00764.x
   Franchimont D, 2004, ANN NY ACAD SCI, V1024, P124, DOI 10.1196/annals.1321.009
   Gibson D M, 1972, Adv Enzyme Regul, V10, P187, DOI 10.1016/0065-2571(72)90014-3
   Gluckman PD, 2004, TRENDS ENDOCRIN MET, V15, P183, DOI 10.1016/j.tem.2004.03.002
   Goldstein RE, 2002, AM J PHYSIOL-ENDOC M, V283, pE946, DOI 10.1152/ajpendo.00320.2002
   GRANGER DN, 1994, J LEUKOCYTE BIOL, V55, P662, DOI 10.1002/jlb.55.5.662
   Gregor MF, 2007, J LIPID RES, V48, P1905, DOI 10.1194/jlr.R700007-JLR200
   Haas JT, 2009, CURR OPIN LIPIDOL, V20, P206, DOI 10.1097/MOL.0b013e32832b2024
   HALE DE, 1992, J PEDIATR-US, V121, P1, DOI 10.1016/S0022-3476(05)82532-6
   HARVEY JW, 1976, J CELL PHYSIOL, V89, P219, DOI 10.1002/jcp.1040890205
   Hauner H, 2002, EUR J CLIN NUTR, V56, pS25, DOI 10.1038/sj.ejcn.1601350
   Hermoso M, 2003, IUBMB LIFE, V55, P497, DOI 10.1080/15216540310001642072
   Hoffmann IS, 2009, NUTR METAB CARDIOVAS, V19, P123, DOI 10.1016/j.numecd.2008.02.011
   Hosogai N, 2007, DIABETES, V56, P901, DOI 10.2337/db06-0911
   Hotamisligil GS, 2008, INT J OBESITY, V32, pS52, DOI 10.1038/ijo.2008.238
   Hotamisligil GS, 2010, NAT MED, V16, P396, DOI 10.1038/nm0410-396
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   Hube F, 1996, HORM METAB RES, V28, P690, DOI 10.1055/s-2007-979879
   Hussain SG, 2007, CURR SCI INDIA, V93, P1684
   Ingelsson E, 2008, EUR J CLIN INVEST, V38, P502, DOI 10.1111/j.1365-2362.2008.01962.x
   Jaggers JR, 2009, EUR J CANCER, V45, P1831, DOI 10.1016/j.ejca.2009.01.031
   Johnson RJ, 2007, AM J CLIN NUTR, V86, P899
   Karadag AS, 2010, INT J DERMATOL, V49, P642, DOI 10.1111/j.1365-4632.2009.04358.x
   KATO T, 1973, J NEUROCHEM, V20, P151, DOI 10.1111/j.1471-4159.1973.tb12112.x
   Kaufman RJ, 2002, NAT REV MOL CELL BIO, V3, P411, DOI 10.1038/nrm829
   Khoa D Nguyen, 2011, Nature Medicine, P43
   Kintscher U, 2008, ARTERIOSCL THROM VAS, V28, P1304, DOI 10.1161/ATVBAHA.108.165100
   Kobayasi R, 2010, J HYPERTENS, V28, P2111, DOI 10.1097/HJH.0b013e32833ca68c
   Labayen I, 2006, J NUTR, V136, P147, DOI 10.1093/jn/136.1.147
   Leibel RL, 2002, NUTR REV, V60, pS15, DOI 10.1301/002966402320634788
   Leung-Pineda V, 2002, J BIOL CHEM, V277, P16585, DOI 10.1074/jbc.M110972200
   Levin BE, 2005, ENDOCRINOLOGY, V146, P1674, DOI 10.1210/en.2005-0013
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Li H, 2008, METABOLISM, V57, P1704, DOI 10.1016/j.metabol.2008.07.029
   Loeser JD, 1999, LANCET, V353, P1607, DOI 10.1016/S0140-6736(99)01311-2
   Lumeng CN, 2007, DIABETES, V56, P16, DOI 10.2337/db06-1076
   Maachi M, 2004, INT J OBESITY, V28, P993, DOI 10.1038/sj.ijo.0802718
   MACADAMS MR, 1986, ANN INTERN MED, V104, P648, DOI 10.7326/0003-4819-104-5-648
   MacGlashan Donald Jr., 2003, Journal of Allergy and Clinical Immunology, V112, pS53, DOI 10.1016/S0091-6749(03)01877-3
   Maderna P, 2003, BBA-MOL BASIS DIS, V1639, P141, DOI 10.1016/j.bbadis.2003.09.004
   MAJNO G, 1961, J BIOPHYS BIOCHEM CY, V11, P571, DOI 10.1083/jcb.11.3.571
   Manco M, 2010, ENDOCR REV, V31, P817, DOI 10.1210/er.2009-0030
   Marchesi C, 2009, HYPERTENSION, V54, P1384, DOI 10.1161/HYPERTENSIONAHA.109.138305
   Marcolongo P, 2008, BIOCHEM PHARMACOL, V76, P382, DOI 10.1016/j.bcp.2008.05.027
   Matsuo Y, 2008, CIRC J, V72, P2046, DOI 10.1253/circj.CJ-08-0337
   Mauras N, 2010, J CLIN ENDOCR METAB, V95, P1060, DOI 10.1210/jc.2009-1887
   Maury E, 2010, MOL CELL ENDOCRINOL, V314, P1, DOI 10.1016/j.mce.2009.07.031
   May RC, 1996, KIDNEY INT, V49, P679, DOI 10.1038/ki.1996.96
   McGuckin MA, 2010, AM J PHYSIOL-GASTR L, V298, pG820, DOI 10.1152/ajpgi.00063.2010
   Meijer K, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017154
   Melanson EL, 2009, ANN NUTR METAB, V55, P229, DOI 10.1159/000229004
   Misra A, 2010, J AM COLL NUTR, V29, p289S, DOI 10.1080/07315724.2010.10719844
   Monteiro R, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/289645
   Muñoz S, 2010, DIABETOLOGIA, V53, P2417, DOI 10.1007/s00125-010-1840-7
   Murphy C, 1998, CLIN SCI, V95, P397, DOI 10.1042/CS19980194
   Najzer M, 2006, NATURE, V444, P1009
   Natsui K, 2006, OSTEOPOROSIS INT, V17, P105, DOI 10.1007/s00198-005-1923-3
   NOUGUES J, 1993, INT J OBESITY, V17, P159
   OCONNELL RC, 1974, J CLIN ENDOCR METAB, V39, P555, DOI 10.1210/jcem-39-3-555
   Odermatt A, 2006, MOL CELL ENDOCRINOL, V248, P15, DOI 10.1016/j.mce.2005.11.040
   Oswal A, 2010, OBESITY, V18, P221, DOI 10.1038/oby.2009.228
   Ota T, 2008, J CLIN INVEST, V118, P316, DOI 10.1172/JCI32752
   Ouchi N, 2007, CLIN CHIM ACTA, V380, P24, DOI 10.1016/j.cca.2007.01.026
   PALOU A, 1981, HORM METAB RES, V13, P326, DOI 10.1055/s-2007-1019258
   Pasarica M, 2009, DIABETES, V58, P718, DOI 10.2337/db08-1098
   Pereira MA, 2006, INT J OBESITY, V30, pS28, DOI 10.1038/sj.ijo.0803489
   Polotsky VY, 2010, PHYSIOL GENOMICS, V41, P306, DOI 10.1152/physiolgenomics.00091.2009
   Ragheb R, 2009, BIOCHEM BIOPH RES CO, V389, P211, DOI 10.1016/j.bbrc.2009.08.106
   Rao RV, 2004, CELL DEATH DIFFER, V11, P372, DOI 10.1038/sj.cdd.4401378
   Rao RV, 2004, CURR OPIN CELL BIOL, V16, P653, DOI 10.1016/j.ceb.2004.09.012
   Remesar X, 2012, MED RES REV, V32, P1263, DOI 10.1002/med.20240
   Reutrakul S, 2004, THYROID, V14, P311, DOI 10.1089/105072504323030988
   Reynolds RM, 2003, DIABETES OBES METAB, V5, P5, DOI 10.1046/j.1463-1326.2003.00221.x
   Rizvi AA, 2007, CHINESE MED J-PEKING, V120, P1918, DOI 10.1097/00029330-200711010-00014
   Roche HM, 2005, P NUTR SOC, V64, P371, DOI 10.1079/PNS2005445
   Ron D, 2007, NAT REV MOL CELL BIO, V8, P519, DOI 10.1038/nrm2199
   Rosenthal SR, 1939, J EXP MED, V70, P415, DOI 10.1084/jem.70.4.415
   Russo A, 2008, EUR J CANCER, V44, P293, DOI 10.1016/j.ejca.2007.11.005
   Ruzzin J, 2005, DIABETOLOGIA, V48, P2119, DOI 10.1007/s00125-005-1886-0
   Ryan TJ, 2006, LYMPHOLOGY, V39, P49
   Saad MF, 1997, J CLIN ENDOCR METAB, V82, P579, DOI 10.1210/jc.82.2.579
   Salgado-Somoza A, 2012, CLIN ENDOCRINOL, V76, P51, DOI 10.1111/j.1365-2265.2011.04140.x
   Saltiel AR, 2001, NATURE, V414, P799, DOI 10.1038/414799a
   Sanchis D, 1996, INT J OBESITY, V20, P588
   Schäffler A, 2005, NEUROPEPTIDES, V39, P363, DOI 10.1016/j.npep.2005.06.003
   Scheuner D, 2008, ENDOCR REV, V29, P317, DOI 10.1210/er.2007-0039
   Schmitz-Peiffer C, 2000, CELL SIGNAL, V12, P583, DOI 10.1016/S0898-6568(00)00110-8
   Schwartz MW, 2001, EXP BIOL MED, V226, P978, DOI 10.1177/153537020122601103
   Serhan CN, 2005, NAT IMMUNOL, V6, P1191, DOI 10.1038/ni1276
   Sherwood Edward R, 2004, Best Pract Res Clin Anaesthesiol, V18, P385, DOI 10.1016/S1521-6896(03)00116-2
   Sorrells SF, 2009, NEURON, V64, P33, DOI 10.1016/j.neuron.2009.09.032
   Sorrentino MJ, 2005, AM J CARDIOL, V96, p3E, DOI 10.1016/j.amjcard.2005.05.008
   Su HL, 2002, J VIROL, V76, P4162, DOI 10.1128/JVI.76.9.4162-4171.2002
   Summers LKM, 1996, CLIN SCI, V91, P679, DOI 10.1042/cs0910679
   Száraz P, 2010, INT J BIOCHEM CELL B, V42, P157, DOI 10.1016/j.biocel.2009.10.004
   Szegezdi E, 2006, EMBO REP, V7, P880, DOI 10.1038/sj.embor.7400779
   Tappy L, 2010, PHYSIOL REV, V90, P23, DOI 10.1152/physrev.00019.2009
   Tarricone E, 2006, ANN NY ACAD SCI, V1069, P472, DOI 10.1196/annals.1351.046
   Teijeira-Fernandez E, 2011, CYTOKINE, V54, P185, DOI 10.1016/j.cyto.2011.01.016
   Tischner D, 2007, MOL CELL ENDOCRINOL, V275, P62, DOI 10.1016/j.mce.2007.03.007
   Trayhurn P, 2004, BRIT J NUTR, V92, P347, DOI 10.1079/BJN20041213
   Trayhurn P, 2008, BRIT J NUTR, V100, P227, DOI 10.1017/S0007114508971282
   TUBIASH HS, 1951, AM J PUBLIC HEALTH, V41, P833
   Turhan H, 2004, AM HEART J, V148, P789, DOI 10.1016/j.ahj.2004.05.016
   Uddén J, 2002, HORM METAB RES, V34, P698, DOI 10.1055/s-2002-38257
   Vachharajani V, 2009, IUBMB LIFE, V61, P424, DOI 10.1002/iub.169
   Valle M, 2005, DIABETES METAB, V31, P55, DOI 10.1016/S1262-3636(07)70167-2
   van Dijk SJ, 2009, AM J CLIN NUTR, V90, P1656, DOI 10.3945/ajcn.2009.27792
   Vilà R, 2011, J STEROID BIOCHEM, V124, P99, DOI 10.1016/j.jsbmb.2011.01.017
   Voeltz GK, 2002, EMBO REP, V3, P944, DOI 10.1093/embo-reports/kvf202
   Volek JS, 2005, NUTR METAB, V2
   von der Weid PY, 2010, ALIMENT PHARM THER, V32, P697, DOI 10.1111/j.1365-2036.2010.04407.x
   Wang D, 2006, ENDOCRINOLOGY, V147, P943, DOI 10.1210/en.2005-0570
   Wang P, 2008, PHYSIOL BEHAV, V94, P198, DOI 10.1016/j.physbeh.2007.11.008
   Wang Y, 2009, INT J OBESITY, V33, P621, DOI 10.1038/ijo.2009.45
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   WEST DB, 1987, AM J PHYSIOL, V253, pR228, DOI 10.1152/ajpregu.1987.253.2.R228
   WILLIAMS TJ, 1977, NATURE, V270, P530, DOI 10.1038/270530a0
   Wisse BE, 2004, J AM SOC NEPHROL, V15, P2792, DOI 10.1097/01.ASN.0000141966.69934.21
   Wisse BE, 2009, CELL METAB, V10, P241, DOI 10.1016/j.cmet.2009.09.003
   Woods SC, 2008, J CLIN ENDOCR METAB, V93, pS37, DOI 10.1210/jc.2008-1630
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yeager MP, 2011, DOSE-RESPONSE, V9, P332, DOI 10.2203/dose-response.10-013.Yeager
   Yin J, 2009, AM J PHYSIOL-ENDOC M, V296, pE333, DOI 10.1152/ajpendo.90760.2008
   Zhang L, 2011, AM J PHYSIOL-ENDOC M, V301, pE599, DOI 10.1152/ajpendo.00059.2011
   Zhang P, 2009, ARTERIOSCL THROM VAS, V29, P67, DOI 10.1161/ATVBAHA.108.178061
   ZHANG YY, 1994, NATURE, V372, P425, DOI 10.1038/372425a0
   Zimmermann MB, 2008, INT J OBESITY, V32, pS11, DOI 10.1038/ijo.2008.202
NR 184
TC 21
Z9 25
U1 0
U2 26
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD JAN
PY 2013
VL 33
IS 1
BP 1
EP 11
DI 10.1016/j.nutres.2012.11.013
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 084TE
UT WOS:000314561200001
PM 23351404
DA 2025-06-11
ER

PT J
AU Koskinen, J
   Magnussen, CG
   Wuertz, P
   Soininen, P
   Kangas, AJ
   Viikari, JSA
   Kahonen, M
   Loo, BM
   Jula, A
   Ahotupa, M
   Lehtimaki, T
   Ala-Korpela, M
   Juonala, M
   Raitakari, OT
AF Koskinen, Juha
   Magnussen, Costan G.
   Wuertz, Peter
   Soininen, Pasi
   Kangas, Antti J.
   Viikari, Jorma S. A.
   Kahonen, Mika
   Loo, Britt-Marie
   Jula, Antti
   Ahotupa, Markku
   Lehtimaki, Terho
   Ala-Korpela, Mika
   Juonala, Markus
   Raitakari, Olli T.
TI Apolipoprotein B, oxidized low-density lipoprotein, and LDL particle
   size in predicting the incidence of metabolic syndrome: the
   Cardiovascular Risk in Young Finns study
SO EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
LA English
DT Article
DE Apolipoproteins; lipids; lipoproteins; metabolic syndrome; oxidative
   stress
ID INTIMA-MEDIA THICKNESS; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   CHOLESTEROL; ASSOCIATION; OBESITY; PLASMA; NUMBER; MEN
AB Objective: To test whether serum apolipoprotein B (apoB) and low-density lipoprotein (LDL) particle characteristics (oxidation and mean particle size) predict the incidence of metabolic syndrome (MetS).
   Methods: The 6-year follow-up study included 1429 adults (baseline mean age 31.5). Lipids, apoB, and apoA1 were measured at baseline in 2001. LDL oxidation was measured with monoclonal antibody-based enzyme-linked immunosorbent assay (oxLDL-prot) and with a method measuring oxidized lipids in LDL (oxLDL-lipids). Mean LDL particle size was calculated from proton nuclear magnetic resonance spectroscopy data.
   Results: Increased concentrations of both oxLDL-measures were associated with increased apoB levels but not with LDL particle size. The odds ratios (95% confidence intervals) for MetS incidence during a 6-year follow up by quartiles of apoB were 2.0 (1.0-3.8) for the second quartile, 3.1 (1.7-5.7) for the third quartile, and 4.2 (2.3-7.6) for the fourth quartile. This association remained after adjusting for age, sex, body mass index, homeostasis model assessment for insulin resistance, C-reactive protein, smoking, LDL cholesterol, oxidized LDL measures (p <= 0.01) in addition to risk factors comprising the MetS (p = 0.03). OxLDL-prot and oxLDL-lipids levels were not independently associated with incident MetS after adjusting for apoB. Mean LDL particle size was not associated with the incidence of MetS.
   Conclusion: ApoB is associated with increased risk of MetS incidence. We found no clear evidence to suggest that increased LDL oxidation or small mean LDL particle size would facilitate the development of MetS.
C1 [Koskinen, Juha; Magnussen, Costan G.; Juonala, Markus; Raitakari, Olli T.] Univ Turku, Turku, Finland.
   [Magnussen, Costan G.] Univ Tasmania, Hobart, Tas 7001, Australia.
   [Wuertz, Peter; Soininen, Pasi; Kangas, Antti J.; Ala-Korpela, Mika] Univ Oulu, Oulu, Finland.
   [Soininen, Pasi; Ala-Korpela, Mika] Univ Eastern Finland, Kuopio, Finland.
   [Viikari, Jorma S. A.; Juonala, Markus; Raitakari, Olli T.] Turku Univ Hosp, FIN-20520 Turku, Finland.
   [Kahonen, Mika; Lehtimaki, Terho] Univ Tampere, FIN-33101 Tampere, Finland.
   [Kahonen, Mika; Lehtimaki, Terho] Tampere Univ Hosp, Tampere, Finland.
   [Loo, Britt-Marie; Jula, Antti] Natl Inst Hlth & Welf, Turku, Finland.
C3 University of Turku; University of Tasmania; University of Oulu;
   University of Eastern Finland; University of Turku; Tampere University;
   Tampere University; Tampere University Hospital; Finland National
   Institute for Health & Welfare
RP Koskinen, J (corresponding author), Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Kiinamyllynkatu 10, FI-20520 Turku, Finland.
EM jkkosk@utu.fi
RI Lehtimäki, Terho/AAD-1094-2022; Gratten, Jacob/G-1485-2011; Raitakari,
   Olli/AAQ-7389-2021; Magnussen, Costan/AAA-8260-2020; Magnussen,
   Costan/J-7177-2014
OI Magnussen, Costan/0000-0002-6238-5730; Ala-Korpela,
   Mika/0000-0001-5905-1206; Wurtz, Peter/0000-0002-5832-0221; Juonala,
   Markus/0000-0001-9498-364X; Kahonen, Mika/0000-0002-4510-7341;
   Lehtimaki, Terho/0000-0002-2555-4427; Kangas, Antti/0000-0001-7492-1732
FU Academy of Finland [117797, 121584, 126925, 137870, 129429]; Social
   Insurance Institution of Finland; Instrumentarium Science Foundation;
   Finnish government; Turku University Hospitals; Jenny and Antti Wihuri
   Foundation; Finnish Foundation for Cardiovascular Research; Turku
   University Foundation; Turku University; Juho Vainio Foundation; Lydia
   Maria Julin Foundation; Aarne and Aili Turunen foundation; Tampere
   Tuberculosis Foundation; Finnish Medical Foundation; Paavo Nurmi
   Foundation; Finnish Cultural Foundation; Academy of Finland (AKA)
   [117797, 137870, 129429] Funding Source: Academy of Finland (AKA)
FX This work was supported by the Academy of Finland (grant numbers 117797,
   121584, 126925, 137870, 129429), Social Insurance Institution of
   Finland, Instrumentarium Science Foundation, Finnish government grants
   to Tampere, Kuopio and Turku University Hospitals, Jenny and Antti
   Wihuri Foundation, Finnish Foundation for Cardiovascular Research, Turku
   University Foundation, Turku University, Juho Vainio Foundation, Lydia
   Maria Julin Foundation, Aarne and Aili Turunen foundation, Tampere
   Tuberculosis Foundation, Finnish Medical Foundation, Paavo Nurmi
   Foundation and Finnish Cultural Foundation.
CR Ahotupa M, 1999, FREE RADICAL BIO MED, V27, P1141, DOI 10.1016/S0891-5849(99)00201-4
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Bamba V, 2007, GASTROENTEROLOGY, V132, P2181, DOI 10.1053/j.gastro.2007.03.056
   Barter PJ, 2006, J INTERN MED, V259, P247, DOI 10.1111/j.1365-2796.2006.01616.x
   Carmena R, 2004, CIRCULATION, V109, P2, DOI 10.1161/01.CIR.0000131511.50734.44
   CHAIT A, 1993, AM J MED, V94, P350, DOI 10.1016/0002-9343(93)90144-E
   Cromwell WC, 2006, AM J CARDIOL, V98, P1599, DOI 10.1016/j.amjcard.2006.07.036
   ESTERBAUER H, 1992, FREE RADICAL BIO MED, V13, P341, DOI 10.1016/0891-5849(92)90181-F
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Ginsberg HN, 2006, OBESITY, V14, p41S, DOI 10.1038/oby.2006.281
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Holvoet P, 2004, DIABETES, V53, P1068, DOI 10.2337/diabetes.53.4.1068
   Holvoet P, 2008, JAMA-J AM MED ASSOC, V299, P2287, DOI 10.1001/jama.299.19.2287
   Hulthe J, 2000, J INTERN MED, V248, P42, DOI 10.1046/j.1365-2796.2000.00698.x
   Juonala M, 2004, J INTERN MED, V255, P457, DOI 10.1111/j.1365-2796.2004.01308.x
   Kathiresan S, 2006, CIRCULATION, V113, P20, DOI 10.1161/CIRCULATIONAHA.105.567107
   Knuiman MW, 2009, EUR J CARDIOV PREV R, V16, P235, DOI 10.1097/HJR.0b013e32832955fc
   Kondo T, 2011, EUR J CARDIOVASC PRE
   Koskinen J, 2010, CIRCULATION, V121, P392, DOI 10.1161/CIRCULATIONAHA.109.894584
   Koskinen J, 2009, CIRCULATION, V120, P229, DOI 10.1161/CIRCULATIONAHA.108.845065
   Lamarche B, 1998, CORONARY ARTERY DIS, V9, P473, DOI 10.1097/00019501-199809080-00002
   Maddux BA, 2001, DIABETES, V50, P404, DOI 10.2337/diabetes.50.2.404
   Masella R, 2006, FEBS LETT, V580, P2421, DOI 10.1016/j.febslet.2006.03.068
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mora S, 2007, ATHEROSCLEROSIS, V192, P211, DOI 10.1016/j.atherosclerosis.2006.05.007
   Onat A, 2007, INT J OBESITY, V31, P1119, DOI 10.1038/sj.ijo.0803552
   Öörni K, 2005, ARTERIOSCL THROM VAS, V25, P1678, DOI 10.1161/01.ATV.0000168912.42941.60
   Park K, 2009, DIABETES CARE, V32, P1302, DOI 10.2337/dc09-0259
   Rizzo M, 2007, DIABETES-METAB RES, V23, P14, DOI 10.1002/dmrr.694
   Sigurdardottir V, 2002, J INTERN MED, V252, P440, DOI 10.1046/j.1365-2796.2002.01054.x
   Sjogren P, 2005, ARTERIOSCL THROM VAS, V25, P2580, DOI 10.1161/01.ATV.0000190675.08857.3d
   Sniderman AD, 2001, ANN INTERN MED, V135, P447, DOI 10.7326/0003-4819-135-6-200109180-00014
   Soininen P, 2009, ANALYST, V134, P1781, DOI 10.1039/b910205a
   Würtz P, 2011, MOL BIOSYST, V7, P385, DOI 10.1039/c0mb00066c
NR 35
TC 17
Z9 17
U1 0
U2 11
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 2047-4873
EI 2047-4881
J9 EUR J PREV CARDIOL
JI Eur. J. Prev. Cardiol.
PD DEC
PY 2012
VL 19
IS 6
BP 1296
EP 1303
DI 10.1177/1741826711425343
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 083ZM
UT WOS:000314505600010
PM 21960651
OA Bronze
DA 2025-06-11
ER

PT J
AU Mochel, JP
   Ward, JL
   Blondel, T
   Kundu, D
   Merodio, MM
   Zemirline, C
   Guillot, E
   Giebelhaus, RT
   de la Mata, P
   Iennarella-Servantez, CA
   Blong, A
   Nam, SL
   Harynuk, JJ
   Suchodolski, J
   Tvarijonaviciute, A
   Cerón, JJ
   Bourgois-Mochel, A
   Zannad, F
   Sattar, N
   Allenspach, K
AF Mochel, Jonathan P.
   Ward, Jessica L.
   Blondel, Thomas
   Kundu, Debosmita
   Merodio, Maria M.
   Zemirline, Claudine
   Guillot, Emilie
   Giebelhaus, Ryland T.
   de la Mata, Paulina
   Iennarella-Servantez, Chelsea A.
   Blong, April
   Nam, Seo Lin
   Harynuk, James J.
   Suchodolski, Jan
   Tvarijonaviciute, Asta
   Ceron, Jose Joaquin
   Bourgois-Mochel, Agnes
   Zannad, Faiez
   Sattar, Naveed
   Allenspach, Karin
TI Preclinical modeling of metabolic syndrome to study the pleiotropic
   effects of novel antidiabetic therapy independent of obesity
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Western diet; Metabolic syndrome; Cardiorenal metabolic diseases; One
   health
ID FERRIC-REDUCING ABILITY; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   BLOOD-PRESSURE; ANIMAL-MODELS; NT-PROBNP; DOG; ASSAY; FAT; VALIDATION
AB Cardiovascular-kidney-metabolic health reflects the interactions between metabolic risk factors, chronic kidney disease, and the cardiovascular system. A growing body of literature suggests that metabolic syndrome (MetS) in individuals of normal weight is associated with a high prevalence of cardiovascular diseases and an increased mortality. The aim of this study was to establish a non-invasive preclinical model of MetS in support of future research focusing on the effects of novel antidiabetic therapies beyond glucose reduction, independent of obesity. Eighteen healthy adult Beagle dogs were fed an isocaloric Western diet (WD) for ten weeks. Biospecimens were collected at baseline (BAS1) and after ten weeks of WD feeding (BAS2) for measurement of blood pressure (BP), serum chemistry, lipoprotein profiling, blood glucose, glucagon, insulin secretion, NT-proBNP, angiotensins, oxidative stress biomarkers, serum, urine, and fecal metabolomics. Differences between BAS1 and BAS2 were analyzed using non-parametric Wilcoxon signed-rank testing. The isocaloric WD model induced significant variations in several markers of MetS, including elevated BP, increased glucose concentrations, and reduced HDL-cholesterol. It also caused an increase in circulating NT-proBNP levels, a decrease in serum bicarbonate, and significant changes in general metabolism, lipids, and biogenic amines. Short-term, isocaloric feeding with a WD in dogs replicated key biological features of MetS while also causing low-grade metabolic acidosis and elevating natriuretic peptides. These findings support the use of the WD canine model for studying the metabolic effects of new antidiabetic therapies independent of obesity.
C1 [Mochel, Jonathan P.; Bourgois-Mochel, Agnes; Allenspach, Karin] Univ Georgia, Coll Vet Med, Dept Pathol, Precis One Hlth Initiat, 501 DW Brooks Dr, Athens, GA 30602 USA.
   [Mochel, Jonathan P.; Kundu, Debosmita; Iennarella-Servantez, Chelsea A.; Bourgois-Mochel, Agnes; Allenspach, Karin] Iowa State Univ, SMART Pharmacol, Ames, IA 50011 USA.
   [Ward, Jessica L.; Merodio, Maria M.; Blong, April] Iowa State Univ, Vet Clin Sci, Ames, IA 50011 USA.
   [Blondel, Thomas; Zemirline, Claudine; Guillot, Emilie] Ceva Sante Anim, F-33500 Libourne, France.
   [Giebelhaus, Ryland T.; de la Mata, Paulina; Nam, Seo Lin; Harynuk, James J.] Univ Alberta, Dept Chem, Metabol Innovat Ctr, Edmonton, AB T6G 2G2, Canada.
   [Suchodolski, Jan] Texas A&M Univ, Gastrointestinal Lab, College Stn, TX 77845 USA.
   [Tvarijonaviciute, Asta; Ceron, Jose Joaquin] Univ Murcia, Interdisciplinary Lab Clin Anal Interlab UMU, Sch Vet, Reg Campus Int Excellence Campus Mare Nostrum, Murcia 30100, Spain.
   [Zannad, Faiez] Univ Lorraine, Ctr Invest Clin Plurithemat 1433, F-54000 Nancy, France.
   [Zannad, Faiez] CHRU Nancy, Inserm U1116, FCRIN INI CRCT, F-54000 Nancy, France.
   [Sattar, Naveed] Univ Glasgow, BHF Glasgow Cardiovasc Res Ctr, Sch Cardiovasc & Metab Hlth, 126 Univ Pl, Glasgow G12 8TA, Lanark, Scotland.
C3 University System of Georgia; University of Georgia; Iowa State
   University; Iowa State University; Ceva Sante Animale; University of
   Alberta; Texas A&M University System; Texas A&M University College
   Station; University of Murcia; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite de Lorraine; CHU de Nancy;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   University of Glasgow
RP Mochel, JP (corresponding author), Univ Georgia, Coll Vet Med, Dept Pathol, Precis One Hlth Initiat, 501 DW Brooks Dr, Athens, GA 30602 USA.; Mochel, JP (corresponding author), Iowa State Univ, SMART Pharmacol, Ames, IA 50011 USA.
EM jpmochel@uga.edu
RI Mochel, Jon/AAR-3496-2021; Blong, April/B-5373-2017; Sattar,
   Naveed/AFN-0504-2022; Harynuk, James/AAJ-9376-2020
OI Mochel, Jonathan/0000-0002-0997-3111; Giebelhaus,
   Ryland/0000-0002-7625-3077
FU Ceva Sante Animale, Libourne (France)
FX This study was sponsored by Ceva Sante Animale, 33500 Libourne (France).
CR Acierno MJ, 2018, J VET INTERN MED, V32, P1803, DOI 10.1111/jvim.15331
   Adamson C, 2021, EUR J HEART FAIL, V23, P1662, DOI 10.1002/ejhf.2308
   Adutwum LA, 2017, ANAL BIOANAL CHEM, V409, P6699, DOI 10.1007/s00216-017-0628-8
   Akinkuolie AO, 2014, CIRC-CARDIOVASC QUAL, V7, P55, DOI 10.1161/CIRCOUTCOMES.113.000675
   Alberti A, 2000, RES CHEM INTERMEDIAT, V26, P253, DOI 10.1163/156856700X00769
   Aleksandrova K, 2021, REDOX BIOL, V42, DOI 10.1016/j.redox.2021.101869
   Alves SP, 2006, J DAIRY SCI, V89, P170, DOI 10.3168/jds.S0022-0302(06)72081-1
   Amjad S, 2021, MOL METAB, V49, DOI 10.1016/j.molmet.2021.101195
   Arnao MB, 1996, ANAL BIOCHEM, V236, P255, DOI 10.1006/abio.1996.0164
   Bamgbola Oluwatoyin Fatai, 2022, Curr Treat Options Pediatr, V8, P96, DOI 10.1007/s40746-022-00240-3
   BATLLE D, 1982, ADV EXP MED BIOL, V151, P239
   Bayes-Genis A, 2023, EUR J HEART FAIL, V25, P1891, DOI 10.1002/ejhf.3036
   Benzie IFF, 1996, ANAL BIOCHEM, V239, P70, DOI 10.1006/abio.1996.0292
   Birkeland KI, 2019, DIABETES OBES METAB, V21, P968, DOI 10.1111/dom.13612
   Bnhegyi G., 2004, Vitamin C, Function and Biochemistry in Animals and Plants, P35, DOI [10.1201/9780203500002-3, DOI 10.1201/9780203500002-3]
   Boden G, 2015, SCI TRANSL MED, V7, DOI 10.1126/scitranslmed.aac4765
   Bolsoni-Lopes A, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-199
   Burger M., 2023, Metabolic acidosis
   Butler J, 2021, EUR HEART J, V42, P1203, DOI 10.1093/eurheartj/ehaa1007
   Campos C, 2009, ANAL BIOCHEM, V392, P37, DOI 10.1016/j.ab.2009.05.024
   Cavaghan MK, 2000, J CLIN INVEST, V106, P329, DOI 10.1172/JCI10761
   Centers for Disease Control and Prevention, National Diabetes Statistics Report. Coexisting conditions and complications
   Chiofalo B, 2020, J VET BEHAV, V37, P86, DOI 10.1016/j.jveb.2019.12.003
   Costa Carolina M. da, 2006, J. Bras. Patol. Med. Lab., V42, P345, DOI 10.1590/S1676-24442006000500006
   Cruz MM, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0710-z
   Domenig O, 2016, SCI REP-UK, V6, DOI 10.1038/srep33678
   Duan RS, 2020, BMC NEUROL, V20, DOI 10.1186/s12883-020-01989-6
   Erel O, 2005, CLIN BIOCHEM, V38, P1103, DOI 10.1016/j.clinbiochem.2005.08.008
   Frühbeck G, 2014, NUTR RES REV, V27, P63, DOI 10.1017/S095442241400002X
   German AJ, 2006, J NUTR, V136, p2031S, DOI 10.1093/jn/136.7.2031S
   Giebelhaus Ryland T, 2022, F1000Res, V11, P1191, DOI 10.12688/f1000research.124194.2
   Giebelhaus RT, 2022, J CHROMATOGR A, V1682, DOI 10.1016/j.chroma.2022.463499
   Gilmore KM, 2015, EXP GERONTOL, V71, P14, DOI 10.1016/j.exger.2015.08.008
   González-Arostegui LG, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11020424
   Gordon I, 2009, PLOS MED, V6, DOI 10.1371/journal.pmed.1000161
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Guo Z, 2020, CLIN CHEM, V66, P483, DOI 10.1093/clinchem/hvaa001
   Heart Disease andStroke Statistics, 2023, Circulation, V147, P00, DOI [10.1161/CIR.0000000000001123, DOI 10.1161/CIR.0000000000001123, DOI 10.1161/CIR.0000000000001184]
   Herrington WG, 2022, NEPHROL DIAL TRANSPL, V37, P1317, DOI 10.1093/ndt/gfac040
   Hishikawa D, 2014, J LIPID RES, V55, P799, DOI 10.1194/jlr.R046094
   Hooper L, 2015, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD011737, 10.1002/14651858.CD011737.pub2]
   Hussain A, 2021, J AM COLL CARDIOL, V77, P559, DOI 10.1016/j.jacc.2020.11.063
   Iennarella-Servantez CA, 2021, J ANIM SCI, V99, P58
   Inzucchi SE, 2020, DIABETES OBES METAB, V22, P631, DOI 10.1111/dom.13938
   Jacob JA, 2016, JAMA-J AM MED ASSOC, V315, P1550, DOI 10.1001/jama.2016.0082
   Jang IS, 2023, IRISH VET J, V76, DOI 10.1186/s13620-023-00233-0
   JOCELYN PC, 1987, METHOD ENZYMOL, V143, P44
   Johnson MC, 2005, COMP CONT EDUC PRACT, V27, P361
   Jose Lahm Cardoso Mauro, 2016, Vet Med Int, V2016, P8675283, DOI 10.1155/2016/8675283
   Kadowaki T, 2022, DIABETES OBES METAB, V24, P2283, DOI 10.1111/dom.14829
   Kaeberlein M, 2016, MAMM GENOME, V27, P279, DOI 10.1007/s00335-016-9638-7
   Kalaitzidis R, 2005, AM J KIDNEY DIS, V45, P851, DOI 10.1053/j.ajkd.2005.01.005
   Kapun AP, 2012, RES VET SCI, V92, P469, DOI 10.1016/j.rvsc.2011.04.014
   Kleinert M, 2018, NAT REV ENDOCRINOL, V14, P140, DOI 10.1038/nrendo.2017.161
   Kopper JJ, 2021, FRONT TOXICOL, V3, DOI 10.3389/ftox.2021.773953
   Kosiborod MN, 2023, NEW ENGL J MED, V389, P1069, DOI 10.1056/NEJMoa2306963
   Lambert DC, 2022, KIDNEY360, V3, P1842, DOI 10.34067/KID.0002402022
   Larner C. D., 2012, PhD thesis
   LITTMAN MP, 1994, J VET INTERN MED, V8, P79, DOI 10.1111/j.1939-1676.1994.tb03202.x
   Lyu Y, 2022, FRONT VET SCI, V9, DOI 10.3389/fvets.2022.801863
   Amigo JM, 2008, TRAC-TREND ANAL CHEM, V27, P714, DOI 10.1016/j.trac.2008.05.011
   Masters AK, 2018, AM J VET RES, V79, P411, DOI 10.2460/ajvr.79.4.411
   Matsuzawa-Nagata N, 2008, METABOLISM, V57, P1071, DOI 10.1016/j.metabol.2008.03.010
   Matyash V, 2008, J LIPID RES, V49, P1137, DOI 10.1194/jlr.D700041-JLR200
   McMurray JJV, 2019, EUR J HEART FAIL, V21, P1402, DOI 10.1002/ejhf.1548
   Minamoto T, 2019, J FELINE MED SURG, V21, P363, DOI 10.1177/1098612X18780060
   Mochel JP, 2019, EUR J PHARM SCI, V128, P103, DOI 10.1016/j.ejps.2018.11.037
   Mochel JP, 2015, REV PHYSIOL BIOCH P, V169, P43, DOI 10.1007/112_2015_27
   Mochel JP, 2015, PHARM RES-DORDR, V32, P1931, DOI 10.1007/s11095-014-1587-9
   Moinard A, 2020, FRONT VET SCI, V7, DOI 10.3389/fvets.2020.566282
   Monnerie S, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-019-56909-7
   Nathan DM, 2015, LANCET DIABETES ENDO, V3, P866, DOI 10.1016/S2213-8587(15)00291-0
   National Health and Nutrition Examination Survey, NHANES 2015-2016: Males and Females over 20 years)
   National Heart Lung and Blood Institute (NHLBI), What is metabolic syndrome?
   National Research Council, 2006, Nutrient Requirements of Dogs and Cats
   Neal B, 2017, NEW ENGL J MED, V377, P644, DOI 10.1056/NEJMoa1611925
   Newsome PN, 2023, J HEPATOL, V79, P1557, DOI 10.1016/j.jhep.2023.07.033
   Oyama K, 2022, EUR HEART J, V43, P2958, DOI 10.1093/eurheartj/ehab530
   Packer M, 2020, EUR J HEART FAIL, V22, P2393, DOI 10.1002/ejhf.2065
   Peña C, 2014, J VET MED SCI, V76, P1305, DOI 10.1292/jvms.13-0475
   Rubio CP, 2018, RES VET SCI, V121, P85, DOI 10.1016/j.rvsc.2018.09.007
   Rubio CP, 2017, J VET DIAGN INVEST, V29, P574, DOI 10.1177/1040638717693883
   Rubio CP, 2016, J VET DIAGN INVEST, V28, P693, DOI 10.1177/1040638716664939
   Persson F, 2018, DIABETES OBES METAB, V20, P344, DOI 10.1111/dom.13077
   Qu WY, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.849060
   R, A Language and Environment for Statistical Computing
   Rix I., Glucagon Physiology, DOI https://www.ncbi.nlm.nih.gov/books/NBK279127/
   Romero-Corral A, 2010, EUR HEART J, V31, P737, DOI [10.1093/eurheartj/ehn347, 10.1093/eurheartj/ehp487]
   Schneider B, 2018, CPT-PHARMACOMET SYST, V7, P65, DOI 10.1002/psp4.12262
   Schneider BK, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-30453-x
   Sebbag L, 2020, MED RES REV, V40, P2566, DOI 10.1002/med.21716
   Seok J, 2013, P NATL ACAD SCI USA, V110, P3507, DOI 10.1073/pnas.1222878110
   Sharma S., 2023, StatPearls internet
   Shi TH, 2020, PREV CHRONIC DIS, V17, DOI 10.5888/pcd17.200020
   Shimodaira M, 2017, ANN NUTR METAB, V71, P150, DOI 10.1159/000480354
   Singletary GE, 2012, J VET INTERN MED, V26, P1330, DOI 10.1111/j.1939-1676.2012.1000.x
   Sinkov NA, 2011, TALANTA, V83, P1079, DOI 10.1016/j.talanta.2010.10.025
   Siri-Tarino PW, 2010, AM J CLIN NUTR, V91, P502, DOI 10.3945/ajcn.2008.26285
   Sivaprakasam S, 2016, PHARMACOL THERAPEUT, V164, P144, DOI 10.1016/j.pharmthera.2016.04.007
   Sotillo S, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-29771-x
   Stoian Marilena, 2014, Maedica (Bucur), V9, P255
   Sumner LW, 2007, METABOLOMICS, V3, P211, DOI 10.1007/s11306-007-0082-2
   Sun HR, 2023, METABOLITES, V13, DOI 10.3390/metabo13040554
   Sun K, 2014, CLIN NUTR, V33, P521, DOI 10.1016/j.clnu.2013.07.010
   Superko HR, 2012, J CLIN LIPIDOL, V6, P496, DOI 10.1016/j.jacl.2012.03.001
   Surjana D, 2010, J NUCLEIC ACIDS, V2010, DOI 10.4061/2010/157591
   Tatzber F, 2003, ANAL BIOCHEM, V316, P147, DOI 10.1016/S0003-2697(02)00652-8
   Tropf M, 2017, J VET INTERN MED, V31, P1000, DOI 10.1111/jvim.14775
   Tvarijonaviciute A, 2012, BMC VET RES, V8, DOI 10.1186/1746-6148-8-147
   Tvarijonaviciute A, 2012, AM J VET RES, V73, P34, DOI 10.2460/ajvr.73.1.34
   Vasquez-Rios G, 2019, J MED CASE REP, V13, DOI 10.1186/s13256-019-2056-1
   Vecchiato CG, 2023, FRONT MICROBIOL, V13, DOI 10.3389/fmicb.2022.1050474
   Verk B, 2017, J VET DIAGN INVEST, V29, P636, DOI 10.1177/1040638717711995
   Ward JL, 2022, J VET INTERN MED, V36, P897, DOI 10.1111/jvim.16401
   Ward JL, 2021, J VET INTERN MED, V35, P2102, DOI 10.1111/jvim.16236
   Waring MJ, 2015, NAT REV DRUG DISCOV, V14, P475, DOI 10.1038/nrd4609
   Wheeler DC, 2020, NEPHROL DIAL TRANSPL, V35, P1700, DOI 10.1093/ndt/gfaa234
   Wieërs MLAJ, 2024, PFLUG ARCH EUR J PHY, V476, P427, DOI 10.1007/s00424-024-02910-7
   Wilshaw J, 2021, J VET INTERN MED, V35, P755, DOI 10.1111/jvim.16083
   WitkoSarsat V, 1996, KIDNEY INT, V49, P1304, DOI 10.1038/ki.1996.186
   Xenoulis PG, 2010, VET J, V183, P12, DOI 10.1016/j.tvjl.2008.10.011
   Xue JH, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.1019615
   Yin W, 2012, J LIPID RES, V53, P51, DOI 10.1194/jlr.M019927
   Zinman B, 2016, NEW ENGL J MED, V374, P1094, DOI 10.1056/NEJMc1600827
   Zoufaly A, 2020, LANCET RESP MED, V8, P1154, DOI 10.1016/S2213-2600(20)30418-5
   Zushin PJH, 2023, J CLIN INVEST, V133, DOI 10.1172/JCI175824
NR 126
TC 2
Z9 2
U1 2
U2 3
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 5
PY 2024
VL 14
IS 1
AR 20665
DI 10.1038/s41598-024-71202-y
PG 22
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 0WO2U
UT WOS:001457725800029
PM 39237601
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Feng, GF
   Feng, LM
   Zhao, Y
AF Feng, Guofang
   Feng, Limin
   Zhao, Ying
TI Association between ratio of γ-glutamyl transpeptidase to high-density
   lipoprotein cholesterol and prevalence of nonalcoholic fatty liver
   disease and metabolic syndrome: a cross-sectional study
SO ANNALS OF TRANSLATIONAL MEDICINE
LA English
DT Article
DE Nonalcoholic fatty liver disease (NAFLD); gamma-glutamyl transpeptidase
   (GGT); high-density lipoprotein cholesterol (HDL-C); metabolic syndrome
   (MS)
ID OXIDATIVE STRESS; RISK; STEATOHEPATITIS; TRANSFERASE; PREDICTORS;
   REDUCTION; FIBROSIS; CHILDREN; WEIGHT; CELLS
AB Background: Metabolic risk factors including obesity, insulin resistance, dyslipidemia, metabolic syndrome (MS), and diabetes are associated with nonalcoholic fatty liver disease (NAFLD). gamma-Glutamyl transpeptidase (GGT) and high- density lipoprotein cholesterol (HDL-C) are associated with insulin resistance, dyslipidemia, oxidative stress, and obesity. We investigated the associations between GGT/HDL-C ratio and prevalence of NAFLD in a Chinese population.
   Methods: The study included 1,813 NAFLD (526 females, 1,287 males) and 4,513 non-NAFLD (3,077 females, 1,436 males) participants. The diagnosis of NAFLD was based on ultrasonography.
   Results: Participants with NAFLD had higher GGT/HDL-C ratio, BMI, WC, TG, TC, and HOMAIR, but lower HDL-C than participants without NAFLD. GGT/HDL-C ratio was significantly associated with prevalence of NAFLD. Specifically, for each 1 unit increase in GGT/HDL-C ratio, the prevalence of NAFLD will increase by 0.3%. As GGT/HDL-C ratio quartiles increased, prevalence of NAFLD/MS in Q4 (highest GGT/HDL-C ratio quartile) was 6.362/3.968 times higher than that in Q1 (lowest GGT/HDL-C ratio quartile). The AUC [0.799 (0.788-0.810)] for GGT/HDL-C ratio was significantly higher than those for GGT and HDL-C alone.
   Conclusions: The present results suggest that GGT/HDL-C ratio can be used as a predictive factor for prevalence of NAFLD after adjustment for confounding variables.
C1 [Feng, Guofang] Zhejiang Univ, Womens Hosp, Sch Med, Hangzhou 310006, Peoples R China.
   [Feng, Limin; Zhao, Ying] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Clin Lab, Qingchun Rd 79, Hangzhou 310003, Peoples R China.
   [Feng, Limin; Zhao, Ying] Key Lab Clin In Vitro Diagnost Tech Zhejiang Prov, Qingchun Rd 79, Hangzhou 310003, Peoples R China.
C3 Zhejiang University; Zhejiang University
RP Zhao, Y (corresponding author), Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Clin Lab, Qingchun Rd 79, Hangzhou 310003, Peoples R China.; Zhao, Y (corresponding author), Key Lab Clin In Vitro Diagnost Tech Zhejiang Prov, Qingchun Rd 79, Hangzhou 310003, Peoples R China.
EM yingzhao@zju.edu.cn
FU Science and Technology Project [LGF19H040017]; Natural Science
   Foundation [LY20H200005]; Education Department of Zhejiang Province
   [Y201636519]
FX This work was supported by grants from the Science and Technology
   Project (LGF19H040017), Natural Science Foundation (LY20H200005), and
   Education Department (Y201636519) of Zhejiang Province.
CR Alam S, 2019, J TRANSL INTERN MED, V7, P106, DOI 10.2478/jtim-2019-0023
   Alam S, 2013, WORLD J HEPATOL, V5, P281, DOI 10.4254/wjh.v5.i5.281
   Albracht-Schulte K, 2019, DIABET METAB SYND OB, V12, P863, DOI 10.2147/DMSO.S203937
   Alkassabany YM, 2014, ARAB J GASTROENTEROL, V15, P76, DOI 10.1016/j.ajg.2014.05.002
   Barbalho SM, 2019, J VASC BRAS, V18
   Borrelli A, 2018, REDOX BIOL, V15, P467, DOI 10.1016/j.redox.2018.01.009
   Can AS, 2010, BMC ENDOCR DISORD, V10, DOI 10.1186/1472-6823-10-18
   Chen HS, 2019, DIABET METAB SYND OB, V12, P2117, DOI 10.2147/DMSO.S219363
   Chen SH, 2011, J DIGEST DIS, V12, P125, DOI 10.1111/j.1751-2980.2011.00487.x
   Cho J, 2017, BIOMED RES INT, V2017, DOI 10.1155/2017/8728017
   Corey KE, 2015, ALIMENT PHARM THER, V41, P301, DOI 10.1111/apt.13035
   Corey KE, 2015, J PEDIATR GASTR NUTR, V60, P360, DOI 10.1097/MPG.0000000000000584
   DeFilippis AP, 2013, ATHEROSCLEROSIS, V227, P429, DOI 10.1016/j.atherosclerosis.2013.01.022
   Dowla S, 2018, J CLIN LIPIDOL, V12, P981, DOI 10.1016/j.jacl.2018.03.089
   Fadaei R, 2019, ARCH PHYSIOL BIOCHEM, V125, P19, DOI 10.1080/13813455.2018.1429475
   Fan NG, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/3805372
   Fang YL, 2018, WORLD J GASTROENTERO, V24, P2974, DOI 10.3748/wjg.v24.i27.2974
   Farrell GC, 2013, NAT REV GASTRO HEPAT, V10, P307, DOI 10.1038/nrgastro.2013.34
   Cruz MAF, 2015, GASTROENTEROL RES, V8, P260, DOI 10.14740/gr685w
   Hossain IA, 2016, DIABETES METAB SYND, V10, pS25, DOI 10.1016/j.dsx.2015.09.005
   Karp DR, 2001, J BIOL CHEM, V276, P3798, DOI 10.1074/jbc.M008484200
   Kasapoglu B, 2016, INDIAN J MED RES, V143, P30, DOI 10.4103/0971-5916.178585
   Klisic A, 2019, MINERVA MED, V110, P191, DOI 10.23736/S0026-4806.19.05978-0
   Klisic A, 2018, EXP CLIN ENDOCR DIAB, V126, P371, DOI 10.1055/s-0043-118667
   Mansour-Ghanaei R, 2019, J FAM MED PRIM CARE, V8, P923, DOI 10.4103/jfmpc.jfmpc_243_18
   National Workshop on Fatty Liver and Alcoholic Liver Disease CSoH Chinese Medical Association; Fatty Liver Expert Committee Chinese Medical Doctor Association, 2018, ZHONGHUA GAN ZANG BI, V26, P195
   Ndrepepa G, 2018, CLIN CHIM ACTA, V476, P130, DOI 10.1016/j.cca.2017.11.026
   Novakovic Tatjana, 2014, Med Arch, V68, P22
   Preuss HG, 2018, J AM COLL NUTR, V37, P457, DOI 10.1080/07315724.2018.1443292
   Ren XX, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0154345
   Saoi M, 2019, J PROTEOME RES
   Wang P, 2017, ANALYST, V142, P1813, DOI 10.1039/c7an00229g
   Weng JP, 2016, DIABETES-METAB RES, V32, P442, DOI 10.1002/dmrr.2827
   Wu KT, 2016, J CLIN LIPIDOL, V10, P420, DOI 10.1016/j.jacl.2015.12.026
   Yang MH, 2016, J CLIN LIPIDOL, V10, P289, DOI 10.1016/j.jacl.2015.11.017
   Yin JJ, 2014, STAT MED, V33, P985, DOI 10.1002/sim.5992
   Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431
NR 37
TC 32
Z9 35
U1 1
U2 15
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2305-5839
EI 2305-5847
J9 ANN TRANSL MED
JI ANN. TRANSL. MED.
PD MAY
PY 2020
VL 8
IS 10
AR 634
DI 10.21037/atm-19-4516
PG 11
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA LU8TW
UT WOS:000538022300024
PM 32566571
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Suriyaprom, K
   Kaewprasert, S
   Putpadungwipon, P
   Namjuntra, P
   Klongthalay, S
AF Suriyaprom, Kanjana
   Kaewprasert, Sarunya
   Putpadungwipon, Pumpath
   Namjuntra, Pisit
   Klongthalay, Suwit
TI Association of antioxidant status and inflammatory markers with
   metabolic syndrome in Thais
SO JOURNAL OF HEALTH POPULATION AND NUTRITION
LA English
DT Article
DE Metabolic syndrome; Antioxidant status; Inflammatory markers;
   Hematological parameters; Thai
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; OBESITY; SERUM; ERYTHROCYTES;
   BIOMARKERS; WOMEN
AB BackgroundAn oxidant/antioxidant disequilibrium has been suggested as having a role in the pathogenesis of some diseases. Metabolic syndrome (MS) is significantly associated with cardiovascular disease and type 2 diabetes. The pathogenesis of MS is complex and not well understood. The purposes of the present study were to compare enzymatic and non-enzyme antioxidants, anthropometric, hematological, and biochemical findings between subjects with MS and without MS and to evaluate the relationship between antioxidant status and hematological parameters with the components of MS.MethodsMetabolic syndrome was assessed by using the modified National Cholesterol Education Program, Adult Treatment Panel III criteria. Three hundred Thais, 124 with MS and 176 without MS, were included in the study. Each subject was tested for erythrocyte superoxide dismutase (SOD), glutathione peroxidase, (GPX), catalase (CAT), albumin and vitamin C levels, and hematological findings.ResultsSubjects with MS had lower SOD and CAT levels than those without MS (p<0.01). Subjects with MS had lower vitamin C and albumin levels than those without MS (p<0.05). The hematological findings were not significantly different between those with and without MS except the white blood cell (WBC) count which was significantly higher in those with MS. SOD and CAT levels were significantly positively associated with HDL-C levels and negatively associated with components of MS. After adjusting for potential covariates, we found lower SOD and vitamin C levels and higher WBC counts were significantly associated with MS (p<0.05).ConclusionsThese findings suggest an alteration in antioxidant status and an increase in inflammatory markers are associated with MS and its components among Thais; subjects with MS may be more likely to have oxidative stress problems.
C1 [Suriyaprom, Kanjana; Putpadungwipon, Pumpath; Namjuntra, Pisit; Klongthalay, Suwit] Rangsit Univ, Fac Med Technol, Paholyothin Rd, Pathum Thani 12000, Thailand.
   [Kaewprasert, Sarunya] Mahidol Univ, Fac Trop Med, Dept Trop Nutr & Food Sci, 420-6 Rajvithi Rd, Bangkok 10400, Thailand.
C3 Rangsit University; Mahidol University
RP Suriyaprom, K (corresponding author), Rangsit Univ, Fac Med Technol, Paholyothin Rd, Pathum Thani 12000, Thailand.
EM kanjana.su@rsu.ac.th
RI K, Suriyaprom/H-2911-2019
FU Rangsit University, Thailand
FX The project was supported by funds from Rangsit University, Thailand.
CR AEBI H, 1984, METHOD ENZYMOL, V105, P121
   Aekplakorn W, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-854
   Al-gaithy ZK, 2012, WORLD J EMERG SURG, V7, DOI 10.1186/1749-7922-7-32
   Amirkhizi F, 2014, OBES RES CLIN PRACT, V8, pE26, DOI 10.1016/j.orcp.2012.07.004
   Baradaran A, 2014, J RES MED SCI, V19, P358
   Bogdanska J J, 2003, Bratisl Lek Listy, V104, P108
   Bowie AG, 2000, J IMMUNOL, V165, P7180, DOI 10.4049/jimmunol.165.12.7180
   Bryan S, 2013, CAN J PHYSIOL PHARM, V91, P22, DOI 10.1139/cjpp-2012-0295
   Cardona F, 2008, EUR J CLIN INVEST, V38, P510, DOI 10.1111/j.1365-2362.2008.01959.x
   Chen SS, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0050456, 10.1371/journal.pone.0049275, 10.1371/journal.pone.0045763, 10.1371/journal.pone.0036784]
   Choi SW, 2008, FREE RADICAL BIO MED, V44, P1217, DOI 10.1016/j.freeradbiomed.2007.12.005
   Dacie JV, 2007, PRACTICAL HAEMATOLOG
   De Marchi E, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/564961
   Farhangi MA, 2013, J HEALTH POPUL NUTR, V31, P58
   Fernandez-Real JM, 2001, J CLIN ENDOCR METAB, V86, P1154, DOI 10.1210/jc.86.3.1154
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Godala Malgorzata, 2015, Pol Merkur Lekarski, V38, P258
   GUTTERIDGE JMC, 1986, BIOCHIM BIOPHYS ACTA, V869, P119, DOI 10.1016/0167-4838(86)90286-4
   Harnroongroj Talabporn, 2002, J Med Assoc Thai, V85, P17
   Jonas MI, 2015, INT J MOL SCI, V16, P25817, DOI 10.3390/ijms161025817
   Karaouzene N, 2011, NUTR METAB CARDIOVAS, V21, P792, DOI 10.1016/j.numecd.2010.02.007
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   KIRKMAN HN, 1987, J BIOL CHEM, V262, P660
   Lebovitz HE, 2001, EXP CLIN ENDOCR DIAB, V109, pS135, DOI 10.1055/s-2001-18576
   LIU TZ, 1982, CLIN CHEM, V28, P2225
   MACKNESS MI, 1993, ATHEROSCLEROSIS, V104, P129, DOI 10.1016/0021-9150(93)90183-U
   Mansego ML, 2011, INT J MOL SCI, V12, P6146, DOI 10.3390/ijms12096146
   Mozumdar A, 2011, DIABETES CARE, V34, P216, DOI 10.2337/dc10-0879
   Nillakupt Kamolthip, 2010, J Med Assoc Thai, V93 Suppl 6, pS179
   Panek Jozefa, 2012, Pol Przegl Chir, V84, P230, DOI 10.2478/v10035-012-0038-8
   García OP, 2013, NUTRIENTS, V5, P5012, DOI 10.3390/nu5125012
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Roche M, 2008, FEBS LETT, V582, P1783, DOI 10.1016/j.febslet.2008.04.057
   Ruderman NB, 2013, J CLIN INVEST, V123, P2764, DOI 10.1172/JCI67227
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Viroonudomphol Duangkamol, 2000, Southeast Asian Journal of Tropical Medicine and Public Health, V31, P325
   Wang YY, 2004, J DIABETES COMPLICAT, V18, P322, DOI 10.1016/S1056-8727(04)00003-0
   Yokota T, 2013, DIABETES CARE, V36, P1341, DOI 10.2337/dc12-1161
   Ziobro A, 2013, MOL CELL BIOCHEM, V378, P267, DOI 10.1007/s11010-013-1617-7
NR 39
TC 27
Z9 29
U1 1
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1606-0997
EI 2072-1315
J9 J HEALTH POPUL NUTR
JI J. Heatlh Popul. Nutr.
PD JAN 3
PY 2019
VL 38
AR 1
DI 10.1186/s41043-018-0158-9
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA HG3RC
UT WOS:000454891100001
PM 30606264
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mancini, A
   Di Segni, C
   Bruno, C
   Olivieri, G
   Guidi, F
   Silvestrini, A
   Meucci, E
   Orlando, P
   Silvestri, S
   Tiano, L
   Pontecorvi, A
AF Mancini, Antonio
   Di Segni, Chantal
   Bruno, Carmine
   Olivieri, Giulio
   Guidi, Francesco
   Silvestrini, Andrea
   Meucci, Elisabetta
   Orlando, Patrick
   Silvestri, Sonia
   Tiano, Luca
   Pontecorvi, Alfredo
TI Oxidative stress in adult growth hormone deficiency: different plasma
   antioxidant patterns in comparison with metabolic syndrome
SO ENDOCRINE
LA English
DT Article
DE Pituitary; Antioxidants; Coenzyme Q10; Insulin-resistance; Metabolic
   syndrome; Precision medicine
ID FACTOR-I; MITOCHONDRIAL PROTECTION; LIFE-SPAN; RESISTANCE
AB Background and aims Growth hormone deficiency (GHD) is a condition associated with increased cardiovascular risk and insulin-resistance. Oxidative stress (OS) could be a mechanism underlying both these phenomena. In order to investigate plasma antioxidant defenses in such condition, we evaluated adults with GHD, compared with controls and metabolic syndrome patients (MetS), studying plasma total antioxidant capacity (TAC) and coenzyme Q10 (CoQ10, lipophilic antioxidant) levels, both in its oxidized and reduced forms, correlating this data with metabolic and hormonal pattern.
   Materials and methods In this case-control study, 51 GHD, 36 controls, and 35 MetS were enrolled. An evaluation of hormonal and metabolic parameters was performed. TAC was measured using the system metmyoglobin -H2O2 and the chromogen ABTS, whose radical form is spectroscopically revealed; latency time (LAG) in the appearance of ABTS. is proportional to antioxidant in sample. CoQ10 was assayed by electrochemical method.
   Results Despite HOMA index was higher in both GHD and MetS (2.2 +/- 0.3 and 3.1 +/- 0.3 vs. 1.2 +/- 0.2 in controls), only in MetS we observed lower LAG levels (64.5 +/- 3.1 s vs. 82.8 +/- 5.8 in GHD and 80.6 +/- 6.6 in controls), suggesting an increased consumption of antioxidants. LAG significantly correlated with uric acid only in MetS (r(2) = 0.65, p < 0.001), suggesting a different pattern of antioxidants. CoQ10 exhibited a trend toward lower levels in GHD, although not significant.
   Conclusions Our data indicate that GHD, although sharing with MetS various metabolic features, including increased HOMA levels, showed a different pattern of plasma antioxidants, suggesting inadequate reactivity toward radical production rather than an antioxidants consumption as in MetS.
C1 [Mancini, Antonio; Di Segni, Chantal; Bruno, Carmine; Olivieri, Giulio; Pontecorvi, Alfredo] Univ Cattolica Sacro Cuore, Operat Unit Endocrinol, Largo A Gemelli 8, I-00168 Rome, Italy.
   [Guidi, Francesco] Univ Cattolica Sacro Cuore, Dept Obstet & Gynecol, Largo A Gemelli 8, I-00168 Rome, Italy.
   [Silvestrini, Andrea; Meucci, Elisabetta] Univ Cattolica Sacro Cuore, Inst Biochem & Clin Biochem, Largo F Vito 1, I-00168 Rome, Italy.
   [Orlando, Patrick; Silvestri, Sonia; Tiano, Luca] Polytech Univ Marche, Dept Life & Environm Sci, Via Brecce Bianche, I-60131 Ancona, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; Catholic University of the
   Sacred Heart; Marche Polytechnic University
RP Mancini, A (corresponding author), Univ Cattolica Sacro Cuore, Operat Unit Endocrinol, Largo A Gemelli 8, I-00168 Rome, Italy.; Silvestrini, A (corresponding author), Univ Cattolica Sacro Cuore, Inst Biochem & Clin Biochem, Largo F Vito 1, I-00168 Rome, Italy.
EM mancini.giac@mclink.it; andrea.silvestrini@unicatt.it
RI Guidi, Francesco/AAS-9209-2021; Bruno, Carmine/CAA-0347-2022; Tiano,
   Luca/ABC-2341-2020; Orlando, Patrick/LSJ-0851-2024; Olivieri,
   Giulio/GXH-8425-2022; Pontecorvi, Alfredo/K-5146-2016; Silvestrini,
   Andrea/B-3410-2009
OI Olivieri, Giulio/0000-0002-8465-3265; Bruno,
   Carmine/0000-0002-3489-0238; Silvestri, Sonia/0000-0003-3302-4335;
   Silvestrini, Andrea/0000-0002-2005-3746; Tiano,
   Luca/0000-0002-7519-7106; PONTECORVI, Alfredo/0000-0003-0570-6865;
   Orlando, Patrick/0000-0002-4203-9611
CR Abdu T. A. M., 2001, CLIN ENDOCRINOL
   Aguirre GA, 2016, J TRANSL MED, V14, DOI 10.1186/s12967-015-0762-z
   [Anonymous], ENERGY AND DEFENCE
   [Anonymous], ENDOCRINOL METAB
   Beshyah S. A., 1995, CLIN ENDOCRINOL
   Bonora E., 2000, Diabetes Care
   Brown-Borg H. M., 1999, ENDOCRINOLOGY
   Brown-Borg H. M., 1999, ENDOCRINE
   Capalbo D., 2017, ENDOCRINE
   Colao A., 2001, CLIN ENDOCRINOL
   Fontana L, 2010, SCIENCE, V328, P321, DOI 10.1126/science.1172539
   Galimov A., 2017, J MOL MED
   García-Fernández M, 2008, ENDOCRINOLOGY, V149, P2433, DOI 10.1210/en.2007-1190
   Giovannini L, 2015, ENDOCR J, V62, P1037, DOI 10.1507/endocrj.EJ15-0337
   Giustina A., 1995, EUR J ENDOCRINOL
   Guevara-Aguirre J, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3001845
   Hauck S. J., 2002, HORM METAB RES
   Holzenberger M, 2003, NATURE, V421, P182, DOI 10.1038/nature01298
   Johansson J. O., 1994, ARTER THROMB
   Jorgensen J. O., 1989, LANCET
   Leonsson M., 2003, CLIN ENDOCRINOL
   Libber S. M., 1990, MEDICINE
   Littarru G. P., 2005, CURR OPIN CLIN NUTR
   Lonn L., 1996, OBES RES
   Mancini A., 2015, CLIN NUTR
   Mancini A., 2010, J ENDOCRINOL INVEST
   Matsuda T., 1998, J PARENTER ENTER NUT
   Matthews DR., 1985, Diabetologia
   Mazziotti G., 2013, NAT REV ENDOCRINOL
   Meucci E., 2003, FERTIL STERIL
   Mohn A, 2005, CLIN ENDOCRINOL, V63, P537, DOI 10.1111/j.1365-2265.2005.02378.x
   Palmiero C. R., 2012, CARDIOL REV
   Pérez R, 2008, WORLD J GASTROENTERO, V14, P2731, DOI 10.3748/wjg.14.2731
   Puche JE, 2008, ENDOCRINOLOGY, V149, P2620, DOI 10.1210/en.2007-1563
   Rice-Evans C., 1994, METHODS ENZYMOL
   Rollo CD, 1996, CAN J ZOOL, V74, P606, DOI 10.1139/z96-070
   Sanz A., 2005, BIOGERONTOLOGY
   Sarafidis PA, 2007, J HUM HYPERTENS, V21, P709, DOI 10.1038/sj.jhh.1002201
   Scacchi M., 2006, J ENDOCRINOL INVEST
   Seiva F. R. F., 2008, GROWTH HORM IGF RES
   Skhanov S., 2001, FEBBS LETT
   Smith J. C., 2002, CLIN ENDOCRINOL
   Suh Y, 2008, P NATL ACAD SCI USA, V105, P3438, DOI 10.1073/pnas.0705467105
   Titterington JS, 2009, ENDOCRINOLOGY, V150, P5478, DOI 10.1210/en.2009-0283
   Verhelst J, 2009, EUR J ENDOCRINOL, V161, pS41, DOI 10.1530/EJE-09-0291
NR 45
TC 14
Z9 15
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD JAN
PY 2018
VL 59
IS 1
BP 130
EP 136
DI 10.1007/s12020-017-1468-1
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FS6OZ
UT WOS:000419918000016
PM 29143180
DA 2025-06-11
ER

PT J
AU Quetglas-Llabrés, MM
   Monserrat-Mesquida, M
   Bouzas, C
   Mateos, D
   Ugarriza, L
   Gómez, C
   Tur, JA
   Sureda, A
AF Quetglas-Llabres, Maria Magdalena
   Monserrat-Mesquida, Margalida
   Bouzas, Cristina
   Mateos, David
   Ugarriza, Lucia
   Gomez, Cristina
   Tur, Josep A.
   Sureda, Antoni
TI Oxidative Stress and Inflammatory Biomarkers Are Related to High Intake
   of Ultra-Processed Food in Old Adults with Metabolic Syndrome
SO ANTIOXIDANTS
LA English
DT Article
DE ultra-processed food; NOVA; metabolic syndrome; oxidative stress;
   inflammation
ID CONSUMPTION; MYELOPEROXIDASE; ACTIVATION; MECHANISMS; EXPRESSION;
   PLASMA; DIET
AB In the last few decades the consumption of ultra-processed foods (UPFs) worldwide has substantially augmented. Increasing evidence suggests that high UPF consumption is associated with an increase in non-communicable diseases, being overweight, and obesity. The aim of this study was to assess how UPF consumption affects oxidative and inflammatory status in the plasma, neutrophils, and urine of old adults with metabolic syndrome. Participants (n = 92) were classified into two groups according to UPF consumption. Dietary intakes were measured by a validated semi-quantitative 143-item food frequency questionnaire and UPF consumption was determined according to the NOVA classification system. Low UPF consumers showed higher adherence to the Mediterranean diet than high UPF consumers. A high intake of fiber and a high concentration of polyphenols in urine were also observed in subjects with low UPF consumption. Despite the absence of differences in biochemical profile, oxidative and inflammatory biomarkers showed some significant changes. Catalase and superoxide dismutase activities were lower in high UPF consumers, whereas myeloperoxidase activity was higher. ROS production in neutrophils stimulated with zymosan was higher in high UPF consumers than in low UPF consumers. Biomarkers such as xanthine oxidase, tumor necrosis factor a (TNFa), interleukin (IL)-6, IL-15, and leptin levels were higher in participants with high intake of UPF. No differences were found in malondialdehyde and other inflammatory cytokines. The current study evidenced that MetS participants with high UPF consumption have a more pro-oxidant and inflammatory profile than those with low UPF consumption, despite showing similar blood biochemical profiles.
C1 [Quetglas-Llabres, Maria Magdalena; Monserrat-Mesquida, Margalida; Bouzas, Cristina; Mateos, David; Ugarriza, Lucia; Gomez, Cristina; Tur, Josep A.; Sureda, Antoni] Univ Balear Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.
   [Quetglas-Llabres, Maria Magdalena; Monserrat-Mesquida, Margalida; Bouzas, Cristina; Mateos, David; Ugarriza, Lucia; Gomez, Cristina; Tur, Josep A.; Sureda, Antoni] Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca 07120, Spain.
   [Monserrat-Mesquida, Margalida; Bouzas, Cristina; Mateos, David; Ugarriza, Lucia; Tur, Josep A.; Sureda, Antoni] Inst Salud Carlos III, Physiopathol Obes & Nutr CIBEROBN, Madrid 28029, Spain.
   [Gomez, Cristina] Univ Hosp Son Espases, Clin Anal Serv, Palma De Mallorca 07198, Spain.
C3 Institut Investigacio Sanitaria Illes Balears (IdISBa); CIBER - Centro
   de Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos
   III; Hospital Universitari Son Espases
RP Tur, JA (corresponding author), Univ Balear Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Tur, JA (corresponding author), Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca 07120, Spain.; Tur, JA (corresponding author), Inst Salud Carlos III, Physiopathol Obes & Nutr CIBEROBN, Madrid 28029, Spain.
EM pep.tur@uib.es
RI Tur, Josep/AAE-5748-2020; Bouzas, Cristina/AAE-2069-2019; Mesquida,
   Margalida/AAB-4773-2019; Sureda, Antoni/N-9588-2019; Quetglas Llabrés,
   Maria/AAA-4412-2019; Mateos, David/N-7366-2018; Tur, Josep/F-5576-2014
OI , Antoni/0000-0001-8656-6838; GOMEZ COBO, CRISTINA/0000-0002-9776-4730;
   Monserrat Mesquida, Margalida/0000-0002-8856-135X; Tur,
   Josep/0000-0002-6940-0761; Bouzas Velasco, Cristina/0000-0002-1407-8461;
   Quetglas Llabres, Maria Magdalena/0000-0003-4155-7780
FU The authors especially thank the participants for their enthusiastic
   collaboration, the personnel for outstanding support, and exceptional
   effort. CIBEROBN is an initiative of Instituto de Salud Carlos III,
   Spain.; CIBEROBN is an initiative of Instituto de Salud Carlos III,
   Spain
FX The authors especially thank the participants for their enthusiastic
   collaboration, the personnel for outstanding support, and exceptional
   effort. CIBEROBN is an initiative of Instituto de Salud Carlos III,
   Spain.
CR AEBI H, 1984, METHOD ENZYMOL, V105, P121
   AINSWORTH BE, 1993, MED SCI SPORT EXER, V25, P71, DOI 10.1249/00005768-199301000-00011
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Anandan A, 2020, ANN NY ACAD SCI, V1459, P19, DOI 10.1111/nyas.14244
   Anatoliotakis N, 2013, CURR TOP MED CHEM, V13, P115, DOI 10.2174/1568026611313020004
   [Anonymous], 2015, Tablas de Composicion de Alimentos, Guia de Practicas (Spanish Food Com-Position Tables)
   [Anonymous], 2009, Plant Phenolics and Human Health: Biochemistry, Nutrition and Pharmacology, DOI DOI 10.1002/9780470531792
   Ares G, 2016, APPETITE, V105, P611, DOI 10.1016/j.appet.2016.06.028
   Bahrampour N, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.932225
   Barbosa LB, 2023, INT J EQUITY HEALTH, V22, DOI 10.1186/s12939-022-01816-z
   Beslay M, 2020, PLOS MED, V17, DOI 10.1371/journal.pmed.1003256
   Bouzas C, 2020, NUTRIENTS, V12, DOI 10.3390/nu12072114
   Capeillère-Blandin C, 1998, BIOCHEM J, V336, P395, DOI 10.1042/bj3360395
   Coletro HN, 2023, INT J FOOD SCI NUTR, V74, P338, DOI 10.1080/09637486.2023.2190058
   Díaz MC, 2020, REV CHIL NUTR, V47, P808, DOI [10.4067/S0717-75182020000500808, 10.4067/s0717-75182020000500808]
   Contreras-Rodriguez O, 2022, REV ENDOCR METAB DIS, V23, P697, DOI 10.1007/s11154-022-09711-2
   da Silva A, 2021, PUBLIC HEALTH NUTR, V24, P3331, DOI 10.1017/S136898002000378X
   DeSalvo KB, 2016, JAMA-J AM MED ASSOC, V315, P457, DOI 10.1001/jama.2015.18396
   Dinu M, 2022, NUTRIENTS, V14, DOI 10.3390/nu14102073
   Donat-Vargas C, 2021, J NUTR, V151, P2390, DOI 10.1093/jn/nxab118
   dos Santos FS, 2023, BRIT J NUTR, V129, P1552, DOI 10.1017/S0007114522000551
   Martins GMD, 2022, PUBLIC HEALTH NUTR, V25, P591, DOI 10.1017/S1368980021004523
   Elizabeth L, 2020, NUTRIENTS, V12, DOI 10.3390/nu12071955
   Fardet A, 2016, FOOD FUNCT, V7, P2338, DOI [10.1039/c6fo00107f, 10.1039/C6FO00107F]
   Fernandes AE, 2023, NUTR METAB CARDIOVAS, V33, P84, DOI 10.1016/j.numecd.2022.09.025
   Fernández-Ballarth JD, 2010, BRIT J NUTR, V103, P1808, DOI 10.1017/S0007114509993837
   Galland L, 2010, NUTR CLIN PRACT, V25, P634, DOI 10.1177/0884533610385703
   Guo L, 2020, J CELL MOL MED, V24, P7094, DOI 10.1111/jcmm.15296
   Hwang DH, 2016, EUR J PHARMACOL, V785, P24, DOI 10.1016/j.ejphar.2016.04.024
   Juul F, 2021, ADV NUTR, V12, P1673, DOI 10.1093/advances/nmab049
   Kearney J, 2010, PHILOS T R SOC B, V365, P2793, DOI 10.1098/rstb.2010.0149
   Konieczna J, 2022, NUTRIENTS, V14, DOI 10.3390/nu14194142
   Kubiliene L, 2015, BMC COMPLEM ALTERN M, V15, DOI 10.1186/s12906-015-0677-5
   Leo EEM, 2021, NUTRITION, V91-92, DOI 10.1016/j.nut.2021.111419
   Levy RB, 2021, CLIN NUTR, V40, P3608, DOI 10.1016/j.clnu.2020.12.018
   Lopez-Garcia E, 2004, AM J CLIN NUTR, V80, P1029, DOI 10.1093/ajcn/80.4.1029
   Quetglas-Llabrés MM, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11050901
   Makni-Maalej K, 2013, BIOCHEM PHARMACOL, V85, P92, DOI 10.1016/j.bcp.2012.10.010
   Mataix-Verdu J., 2013, Tablas de Composicion de Alimentos, V5th
   MCCORD JM, 1969, J BIOL CHEM, V244, P6049
   Menezes CA, 2023, NUTRIENTS, V15, DOI 10.3390/nu15020381
   Mertens E, 2022, EUR J NUTR, V61, P1521, DOI 10.1007/s00394-021-02733-7
   Millar SR, 2022, EUR J NUTR, V61, P3377, DOI 10.1007/s00394-022-02892-1
   Monteiro C.A., 2019, ULTRA PROCESSED FOOD, P1
   Monteiro CA, 2019, PUBLIC HEALTH NUTR, V22, P936, DOI 10.1017/S1368980018003762
   Montero-Salazar H, 2020, BMC MED, V18, DOI 10.1186/s12916-020-01678-8
   Mullen W, 2006, BRIT J NUTR, V96, P107, DOI 10.1079/BJN20061809
   Pan F, 2023, NUTRIENTS, V15, DOI 10.3390/nu15030752
   Poti JM, 2017, CURR OBES REP, V6, P420, DOI 10.1007/s13679-017-0285-4
   Poulsen HE, 2019, FREE RADICAL BIO MED, V145, P336, DOI 10.1016/j.freeradbiomed.2019.10.001
   Song ZY, 2023, FOOD RES INT, V167, DOI 10.1016/j.foodres.2023.112730
   Stocker R, 2004, PHYSIOL REV, V84, P1381, DOI 10.1152/physrev.00047.2003
   Suksatan W, 2022, NUTRIENTS, V14, DOI 10.3390/nu14010174
   Talens Oliag P, 2020, Rev. Com. Cient. AESAN
   Vadillo E, 2012, REV INVEST CLIN, V64, P461
   Wassmann S, 2004, HYPERTENSION, V44, P381, DOI 10.1161/01.HYP.0000142232.29764.a7
   Wuttge DM, 2001, AM J PATHOL, V159, P417, DOI 10.1016/S0002-9440(10)61712-9
NR 57
TC 16
Z9 16
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD AUG
PY 2023
VL 12
IS 8
AR 1532
DI 10.3390/antiox12081532
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA Q2QM2
UT WOS:001056012900001
PM 37627527
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chung, JY
   Seo, MS
   Shim, JY
   Lee, YJ
AF Chung, Ji-Youn
   Seo, Min-Seok
   Shim, Jae-Yong
   Lee, Yong-Jae
TI Sex differences in the relationship between blood mercury concentration
   and metabolic syndrome risk
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE Mercury; Metabolic syndrome; Oxidative stress; Sex differences
ID OXIDATIVE STRESS; METHYLMERCURY EXPOSURE; MYOCARDIAL-INFARCTION;
   LIPID-PEROXIDATION; INSULIN-RESISTANCE; INORGANIC MERCURY; KOREAN
   ADULTS; TREATED RATS; HEALTH; NEUROTOXICITY
AB Background Mercury exposure enhances free radical production and reduces activity of anti-oxidant enzymes, resulting in detrimental health effects. Some researchers have reported an association between blood mercury and increased risk of metabolic syndrome (MetS); however, sex differences in the relationship were not fully considered.
   Aim To examine the sex differences in the relationship between blood mercury concentration and the increased risk of MetS in Korean men and women.
   Materials and methods A nationwide cross-sectional study was conducted to examine the relationship between blood mercury concentration and MetS in 2,976 men and 3,074 women over 19 years of age (aged 19-87 years), using data from the 2010-2012 Korean National Health and Nutrition Examination Survey (KNHANES-V). Multiple logistic regression analysis was used to assess the relationship between blood mercury concentration and the prevalence risk of MetS after adjusting for confounding variables.
   Results Compared to the lowest quartile of blood mercury concentration, the OR (95 % CI) for MetS of the highest quartile in men was 1.62 (1.15-2.28) after adjusting for age, smoking status, alcohol consumption, regular exercise, and BMI. Similarly, in multiple logistic regression analysis using log2-transformed blood mercury as a continuous variable, the OR (95 % CI) for having MetS with doubling of blood mercury was 1.20 (1.05-1.36) after adjusting for the same co-variables. However, the relationship was not observed in women after adjusting for the same co-variables.
   Conclusions Blood mercury concentration was independently associated with an increased risk of MetS in men.
C1 [Chung, Ji-Youn] Seoul Red Cross Hosp, Dept Family Med, Seoul, South Korea.
   [Seo, Min-Seok; Shim, Jae-Yong; Lee, Yong-Jae] Yonsei Univ, Coll Med, Dept Family Med, Seoul 135720, South Korea.
   [Seo, Min-Seok] Yonsei Univ, Grad Sch Med, Seoul 120749, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University
RP Lee, YJ (corresponding author), Yonsei Univ, Coll Med, Dept Family Med, 211 Eonju Ro, Seoul 135720, South Korea.
EM ukyjhome@yuhs.ac
RI Lee, Yong Jae/GLR-4153-2022; Shim, Jae Yong/GLU-2862-2022; Seo,
   Minseok/JXM-0791-2024
OI Seo, Minseok/0000-0001-5551-4891; Shim, JaeYong/0000-0002-9561-9230;
   Lee, Yong-Jae/0000-0002-6697-476X
CR Auger N, 2005, NEUROTOXICOLOGY, V26, P149, DOI 10.1016/j.neuro.2004.12.005
   Borrás C, 2003, FREE RADICAL BIO MED, V34, P546, DOI 10.1016/S0891-5849(02)01356-4
   Cranmer M, 1996, NEUROTOXICOLOGY, V17, P9
   Elnakish MT, 2013, J PATHOL, V231, P290, DOI 10.1002/path.4255
   Eom SY, 2014, INT ARCH OCC ENV HEA, V87, P501, DOI 10.1007/s00420-013-0891-8
   Evans JL, 2005, ANTIOXID REDOX SIGN, V7, P1040, DOI 10.1089/ars.2005.7.1040
   Fortuño A, 2006, DIABETES, V55, P209, DOI 10.2337/diabetes.55.1.209
   Glass DC, 2001, ANN OCCUP HYG, V45, P275, DOI 10.1016/S0003-4878(01)00022-9
   Grundy SM, 2004, ARTERIOSCL THROM VAS, V24, pE13, DOI 10.1161/01.ATV.0000111245.75752.C6
   Houston MC, 2007, ALTERN THER HEALTH M, V13, P128
   Hultman P, 2001, J AUTOIMMUN, V17, P27, DOI 10.1006/jaut.2001.0521
   InSug O, 1997, TOXICOLOGY, V124, P211, DOI 10.1016/S0300-483X(97)00153-4
   JANSSON G, 1993, FREE RADICAL RES COM, V18, P87, DOI 10.3109/10715769309147345
   Jeong HS, 1991, RES REP ENV SCI TECH, V9, P61
   Kim NS, 2011, INT ARCH OCC ENV HEA, V84, P53, DOI 10.1007/s00420-010-0522-6
   Kim YS, 1982, KOREAN J ENV HLTH, V18, P105
   Lee BK, 1999, TOXICOL LETT, V108, P149, DOI 10.1016/S0378-4274(99)00083-1
   Lee BK, 2013, AM J IND MED, V56, P682, DOI 10.1002/ajim.22107
   Lee SY, 2007, DIABETES RES CLIN PR, V75, P72, DOI 10.1016/j.diabres.2006.04.013
   MAGOS L, 1987, ARCH TOXICOL, V60, P422, DOI 10.1007/BF00302384
   Mahaffey Kathryn R, 2005, Trans Am Clin Climatol Assoc, V116, P127
   Mahaffey KR, 2004, ENVIRON HEALTH PERSP, V112, P562, DOI 10.1289/ehp.6587
   Murata K, 2006, INT ARCH OCC ENV HEA, V79, P379, DOI 10.1007/s00420-005-0064-5
   Olivieri G, 2002, NEUROSCIENCE, V113, P849, DOI 10.1016/S0306-4522(02)00211-7
   Ratcliffe HE, 1996, J TOXICOL ENV HEALTH, V49, P221, DOI 10.1080/009841096160817
   Rhee S.Y., 2008, CARDIOVASC DIABETOL, V9, P12
   Romeo GR, 2012, ARTERIOSCL THROM VAS, V32, P1771, DOI 10.1161/ATVBAHA.111.241869
   RUNGBY J, 1992, PHARMACOL TOXICOL, V70, P205, DOI 10.1111/j.1600-0773.1992.tb00458.x
   Salonen JT, 2000, ATHEROSCLEROSIS, V148, P265, DOI 10.1016/S0021-9150(99)00272-5
   SALONEN JT, 1995, CIRCULATION, V91, P645, DOI 10.1161/01.CIR.91.3.645
   Schulz C, 2007, INT J HYG ENVIR HEAL, V210, P271, DOI 10.1016/j.ijheh.2007.01.034
   Taskiran D, 1997, NEUROREPORT, V8, P881, DOI 10.1097/00001756-199703030-00013
   THOMAS DJ, 1987, ENVIRON RES, V43, P203, DOI 10.1016/S0013-9351(87)80072-5
   THOMAS DJ, 1986, ENVIRON RES, V41, P219, DOI 10.1016/S0013-9351(86)80184-0
   Watanabe T, 2000, CLIN CHIM ACTA, V301, P169, DOI 10.1016/S0009-8981(00)00340-5
NR 35
TC 19
Z9 19
U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD JAN
PY 2015
VL 38
IS 1
BP 65
EP 71
DI 10.1007/s40618-014-0132-3
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CC9IH
UT WOS:000350681800007
PM 25053396
DA 2025-06-11
ER

PT J
AU Title, LM
   Lonn, E
   Charbonneau, F
   Fung, M
   Mather, KJ
   Verma, S
   Anderson, TJ
AF Title, Lawrence M.
   Lonn, Evan
   Charbonneau, Francois
   Fung, Marinda
   Mather, Kieren J.
   Verma, Subodh
   Anderson, Todd J.
TI Relationship between brachial artery flow-mediated dilatation, hyperemic
   shear stress, and the metabolic syndrome
SO VASCULAR MEDICINE
LA English
DT Article
DE endothelium; insulin resistance; metabolic syndrome; obesity;
   vasodilation
ID INSULIN-RESISTANCE; ENDOTHELIAL FUNCTION; NITRIC-OXIDE; DISEASE;
   VASODILATION; DYSFUNCTION; DILATION; ADULTS; ASSOCIATION; REACTIVITY
AB Metabolic syndrome (MetSyn) may predispose to cardiovascular disease (CVD) by causing vascular dysfunction. This study aimed to determine the association of MetSyn with vascular function, as assessed by brachial artery flow-mediated dilatation (FMD) and hyperemic shear stress (HSS). A total of 1,417 male firefighters without established diabetes and CVD were classified for MetSyn, according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP) definition. MetSyn was present in 267 individuals (19%). Although FMD was lower in those with versus without MetSyn (8.1 +/- 4.1 vs 8.7 +/- 4.0%; p = 0.02), this was not significant after adjusting for baseline differences (age, smoking, and brachial artery diameter) (p = 0.2). However, HSS was significantly lower in those with versus without MetSyn (72.0 +/- 27.8 vs 80.9 +/- 24.8 dyne/cm(2); p < 0.001), and there was a significant inverse graded relationship with the number of NCEP criteria present (mean HSS for those with 0, 1, 2, 3, 4, and 5 criteria: 83.2 +/- 22.5, 82.2 +/- 24.7, 76.5 +/- 27.2, 74.3 +/- 27.4, 66.5 +/- 28.4, 67.1 +/- 27.6 dyne/cm(2); p < 0.001 for trend). The individual NCEP criteria of abdominal obesity, systolic hypertension, and impaired fasting glucose were independent predictors for HSS. In conclusion, MetSyn was not associated with impaired FMD. Alternatively, HSS, a measure of microvascular function, was significantly lower in those with MetSyn. Thus, MetSyn may contribute to CVD by causing microvascular dysfunction.
C1 [Title, Lawrence M.] Dalhousie Univ, Div Cardiol, Halifax, NS, Canada.
   [Lonn, Evan] McMaster Univ, Div Cardiol, Hamilton, ON, Canada.
   [Charbonneau, Francois; Fung, Marinda; Anderson, Todd J.] Univ Calgary, Div Cardiol, Calgary, AB, Canada.
   [Mather, Kieren J.] Indiana Univ, Div Endocrinol, Indianapolis, IN 46204 USA.
   [Verma, Subodh] Univ Toronto, Div Cardiovasc Surg, Toronto, ON, Canada.
C3 Dalhousie University; McMaster University; University of Calgary;
   Indiana University System; Indiana University Indianapolis; University
   of Toronto
RP Title, LM (corresponding author), Queen Elizabeth 2 Hlth Sci Ctr, Div Cardiol, 6876-1796 Summer St, Halifax, NS B3H 3A7, Canada.
EM ltitle@dal.ca
RI Verma, Subodh/HCH-3619-2022; Mather, Kieren/ABE-4117-2020
FU Heart and Stroke Foundation of Alberta; Canadian Institute of Health
   Research; Pfizer Canada
FX This study was supported by grants from the Heart and Stroke Foundation
   of Alberta, Canadian Institute of Health Research, and Pfizer Canada.
CR Anderson TJ, 2003, CAN J CARDIOL, V19, P61
   Anderson TJ, 2000, J AM COLL CARDIOL, V35, P60, DOI 10.1016/S0735-1097(99)00537-9
   Bahia Luciana, 2006, Clinics, V61, P433, DOI 10.1590/S1807-59322006000500010
   Beckman JA, 2007, DIABETES CARE, V30, P1226, DOI 10.2337/dc06-2142
   Bonora E, 2000, DIABETES CARE, V23, P57, DOI 10.2337/diacare.23.1.57
   CELERMAJER DS, 1992, LANCET, V340, P1111, DOI 10.1016/0140-6736(92)93147-F
   Corretti MC, 2002, J AM COLL CARDIOL, V39, P257, DOI 10.1016/S0735-1097(01)01746-6
   Grundy SM, 2006, J AM COLL CARDIOL, V47, P1093, DOI 10.1016/j.jacc.2005.11.046
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Hamburg NM, 2008, AM J CARDIOL, V101, P82, DOI 10.1016/j.amjcard.2007.07.053
   Hamburg NM, 2007, ARTERIOSCL THROM VAS, V27, P2650, DOI 10.1161/ATVBAHA.107.153288
   Higashi Y, 2001, AM J CARDIOL, V87, P121, DOI 10.1016/S0002-9149(00)01288-1
   Joannides R, 2006, FUND CLIN PHARMACOL, V20, P311, DOI 10.1111/j.1472-8206.2006.00406.x
   JOANNIDES R, 1995, CIRCULATION, V91, P1314, DOI 10.1161/01.CIR.91.5.1314
   Kahn R, 2005, DIABETOLOGIA, V48, P1684, DOI 10.1007/s00125-005-1876-2
   Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lind L, 2008, ATHEROSCLEROSIS, V196, P795, DOI 10.1016/j.atherosclerosis.2007.01.014
   Lorenzo C, 2003, DIABETES CARE, V26, P3153, DOI 10.2337/diacare.26.11.3153
   LOSCALZO J, 1994, CIRCULATION, V90, P2556, DOI 10.1161/01.CIR.90.5.2556
   Lteif A, 2004, CAN J CARDIOL, V20, p66B
   Lteif AA, 2005, CIRCULATION, V112, P32, DOI 10.1161/CIRCULATIONAHA.104.520130
   MCNAMEE CJ, 1994, CIRC RES, V74, P1126, DOI 10.1161/01.RES.74.6.1126
   Meredith IT, 1996, AM J PHYSIOL-HEART C, V270, pH1435, DOI 10.1152/ajpheart.1996.270.4.H1435
   Mitchell GF, 2004, HYPERTENSION, V44, P134, DOI 10.1161/01.HYP.0000137305.77635.68
   O'Brien SF, 1998, CAN J PHYSIOL PHARM, V76, P72, DOI 10.1139/cjpp-76-1-72
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Reilly MP, 2004, CIRCULATION, V110, P803, DOI 10.1161/01.CIR.0000138740.84883.9C
   Sattar N, 2003, CIRCULATION, V108, P414, DOI 10.1161/01.CIR.0000080897.52664.94
   Solymoss BC, 2003, CORONARY ARTERY DIS, V14, P207, DOI 10.1097/01.mca.0000065744.52558.9f
   Tzou WS, 2005, J AM COLL CARDIOL, V46, P457, DOI 10.1016/j.jacc.2005.04.046
   Wendelhag I, 2002, J INTERN MED, V252, P305, DOI 10.1046/j.1365-2796.2002.01036.x
   Yan RT, 2005, J AM COLL CARDIOL, V45, P1980, DOI 10.1016/j.jacc.2004.12.079
   Yeboah J, 2007, CIRCULATION, V115, P2390, DOI 10.1161/CIRCULATIONAHA.106.678276
NR 35
TC 35
Z9 41
U1 0
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1358-863X
EI 1477-0377
J9 VASC MED
JI Vasc. Med.
PD NOV
PY 2008
VL 13
IS 4
BP 263
EP 270
DI 10.1177/1358863X08095154
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 364MK
UT WOS:000260339600004
PM 18940902
OA Green Published
DA 2025-06-11
ER

PT J
AU Wilar, G
   Suhandi, C
   Fukunaga, K
   Shigeno, M
   Kawahata, I
   Abdulah, R
   Sasaki, T
AF Wilar, Gofarana
   Suhandi, Cecep
   Fukunaga, Kohji
   Shigeno, Masanori
   Kawahata, Ichiro
   Abdulah, Rizky
   Sasaki, Takuya
TI Effects of nanocurcumin supplementation on metabolic syndrome: A
   systematic review and meta-analysis of randomized controlled trials
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Nanocurcumin; Metabolic syndrome; Inflammatory markers; Oxidative
   stress; Meta-analysis
ID DOUBLE-BLIND; DIABETES-MELLITUS; NANO-CURCUMIN; HEMODIALYSIS;
   INFLAMMATION; DIFFERENCE; DIAGNOSIS; MARKERS
AB Background: Metabolic syndrome (MetS) encompasses metabolic risk factors like elevated blood glucose, abnormal lipid levels, and hypertension. Nanocurcumin, a nanoscale formulation of curcumin, may offer therapeutic benefits for MetS management. This systematic review and meta-analysis evaluates the impact of nanocurcumin supplementation on key MetS parameters. Methods: A systematic literature search identified 20 randomized controlled trials (RCTs) with 1394 participants. Data were pooled using a random-effects model, and standardized mean differences (SMDs) were calculated for key outcomes. Results: Nanocurcumin supplementation significantly improved waist circumference (WC) (standardized mean difference (SMD): -0.30 cm), fasting blood sugar (FBS) (SMD: -0.34 mg/dL), HbA1c (SMD: -0.33 %), and quantitative insulin sensitivity check index (QUICKI) score (SMD: 0.73). Lipid profile parameters, including total cholesterol (SMD: -0.18 mg/dL), LDL-C (SMD: -0.16 mg/dL), and HDL-C (SMD: 0.32 mg/dL), also reduced significantly. Improvement in diastolic blood pressure (DBP) (SMD: -0.32 mmHg), total antioxidant capacity (TAC) (SMD: 0.44 mmol/L), malondialdehyde (MDA) (SMD: -0.37 mmol/L), tumor necrosis factor-alpha (TNF-alpha) (SMD: -2.30 ng/L), interleukin-6 (IL-6) (SMD: -1.07 ng/L), and high-sensitivity C-reactive protein (hs-CRP) (SMD: -0.34 mg/L) were observed. Conclusion: Nanocurcumin supplementation significantly improves multiple MetS-related parameters, including anthropometric measures, glycemic control, lipid profile, blood pressure, oxidative stress markers, and inflammatory biomarkers. These findings highlight nanocurcumin's potential as an effective adjunctive therapy for managing MetS. However, the variability in study participant ages, treatment durations, and sample sizes suggests the need for further well-designed RCTs to establish optimal usage guidelines.
C1 [Wilar, Gofarana; Suhandi, Cecep; Abdulah, Rizky] Univ Padjadjaran, Fac Pharm, Dept Pharmacol & Clin Pharm, Sumedang 45363, Indonesia.
   [Suhandi, Cecep] Univ Padjadjaran, Fac Pharm, Dept Pharmaceut & Pharmaceut Technol, Sumedang 45363, Indonesia.
   [Fukunaga, Kohji; Kawahata, Ichiro; Sasaki, Takuya] Tohoku Univ, Grad Sch Pharmaceut Sci, Dept Pharmacol, Sendai 9808578, Japan.
   [Fukunaga, Kohji] Tohoku Univ, Grad Sch Pharmaceut Sci, Dept CNS Drug Innovat, Sendai 9808578, Japan.
   [Shigeno, Masanori] Tohoku Univ, Grad Sch Pharmaceut Sci, Dept Biophys Chem, Sendai 9808578, Japan.
C3 Universitas Padjadjaran; Universitas Padjadjaran; Tohoku University;
   Tohoku University; Tohoku University
RP Wilar, G (corresponding author), Univ Padjadjaran, Fac Pharm, Dept Pharmacol & Clin Pharm, Sumedang 45363, Indonesia.
EM g.wilar@unpad.ac.id
RI Abdulah, Rizky/A-6282-2015; Kawahata, Ichiro/A-6443-2017
OI Kawahata, Ichiro/0000-0002-5916-7847
FU Article Review Grant from Universitas Padjadjaran
   [2357/UN6.3.1/PT.00/2024]; Kakenhi
FX This work was primarily supported by the Article Review Grant from
   Universitas Padjadjaran (grant numbers 2357/UN6.3.1/PT.00/2024) (GW) and
   additionally supported by Kakenhi (IK) .
CR Abassi Z, 2022, FRONT CARDIOVASC MED, V9, DOI 10.3389/fcvm.2022.933215
   Afshar GV, 2020, IRAN J KIDNEY DIS, V14, P52
   Alhashemi SH, 2022, AVICENNA J PHYTOMEDI, V12, P503, DOI [10.22038/ajp.2022.20201, 10.22038/AJP.2022.20201]
   Amalraj Augustine, 2017, J Tradit Complement Med, V7, P205, DOI 10.1016/j.jtcme.2016.05.005
   Aminuddin M, 2023, OPEN VET J, V13, P11, DOI 10.5455/OVJ.2023.v13.i1.2
   Andrade C, 2020, J CLIN PSYCHIAT, V81, DOI 10.4088/JCP.20f13681
   [Anonymous], 2020, The Chemistry and Bioactive Components of Turmeric, DOI [10.1039/9781788015936, DOI 10.1039/9781788015936]
   Asadi S, 2020, PHYTOTHER RES, V34, P896, DOI 10.1002/ptr.6571
   Asadi S, 2019, COMPLEMENT THER MED, V43, P253, DOI 10.1016/j.ctim.2019.02.014
   Asghari KM, 2024, NUTR DIABETES, V14, DOI 10.1038/s41387-024-00274-6
   Ashtary-Larky D, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10071015
   Bateni Z, 2021, PHYTOTHER RES, V35, P3945, DOI 10.1002/ptr.7109
   Bateni Z, 2022, J HERB MED, V31, DOI 10.1016/j.hermed.2021.100531
   Bertoncini-Silva C, 2024, ANTIOXIDANTS-BASEL, V13, DOI 10.3390/antiox13030331
   Carresi C, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051504
   Chan LS, 2013, AM J PUBLIC HEALTH, V103, pE24, DOI 10.2105/AJPH.2013.301580
   Colca JR, 2022, MOL METAB, V55, DOI 10.1016/j.molmet.2021.101409
   Cumpston M, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.ED000142
   Dastani M, 2023, BIOFACTORS, V49, P108, DOI 10.1002/biof.1874
   Dehzad MJ, 2023, PHYTOTHER RES, V37, P1703, DOI 10.1002/ptr.7800
   Dehzad MJ, 2023, CYTOKINE, V164, DOI 10.1016/j.cyto.2023.156144
   Dei Cas M, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092147
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Farhoudi L, 2022, INT J PHARMACEUT, V617, DOI 10.1016/j.ijpharm.2022.121622
   Figlioli G, 2024, PHARMACOL RES, V208, DOI 10.1016/j.phrs.2024.107401
   Futuhi Farzaneh, 2022, J Complement Integr Med, V19, P531, DOI 10.1515/jcim-2022-0082
   Ghoran SH, 2022, MOLECULES, V27, DOI 10.3390/molecules27165236
   Gopi S, 2017, PHYTOTHER RES, V31, P1883, DOI 10.1002/ptr.5931
   Gornicka J, 2023, LIFE-BASEL, V13, DOI 10.3390/life13010207
   Guyatt G, 2011, J CLIN EPIDEMIOL, V64, P383, DOI 10.1016/j.jclinepi.2010.04.026
   Hajihashemi P., 2024, Int. Arch. Health Sci., DOI 10.48307iahsj.2024.444695.1148
   Hewlings SJ, 2017, FOODS, V6, DOI 10.3390/foods6100092
   Higgins J.P.T., 2022, Cochrane
   Higgins J.PT., Chapter 8: Assessing risk of bias in a randomized trial
   Imenshahidi M, 2024, BIOMED PHARMACOTHER, V171, DOI 10.1016/j.biopha.2024.116169
   Iweala E. J., 2023, PHARM RES MOD CHIN M, V6, P100222, DOI [DOI 10.1016/J.PRMCM.2023.100222, 10.1016/j.prmcm.2023.100222]
   Jazayeri-Tehrani SA, 2019, NUTR METAB, V16, DOI 10.1186/s12986-019-0331-1
   Jha BK, 2023, DIABETOLOGY, V4, P134, DOI 10.3390/diabetology4020015
   Jin WL, 2021, NEUROREHAB NEURAL RE, V35, P576, DOI 10.1177/15459683211011232
   Kanda H, 2023, ARAB J CHEM, V16, DOI 10.1016/j.arabjc.2023.104585
   Keutmann S, 2020, DIABETES THER, V11, P293, DOI 10.1007/s13300-019-00740-w
   Kim HL, 2022, KOREAN CIRC J, V52, P93, DOI 10.4070/kcj.2021.0328
   Kocaadam B, 2017, CRIT REV FOOD SCI, V57, P2889, DOI 10.1080/10408398.2015.1077195
   Kocher A, 2016, MOL NUTR FOOD RES, V60, P1555, DOI 10.1002/mnfr.201501034
   Li WZ, 2023, JMIR PUBLIC HLTH SUR, V9, DOI 10.2196/44073
   Lukkunaprasit T, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-33023-3
   Mamsharifi P, 2023, HELIYON, V9, DOI 10.1016/j.heliyon.2023.e21249
   Mohamed S.M., 2023, Food Chem Adv, V3, DOI 10.1016/j.focha.2023.100335
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Mokhtari M, 2021, PHYTOTHER RES, V35, P2099, DOI 10.1002/ptr.6957
   Moon JH, 2015, J CLIN LIPIDOL, V9, P334, DOI 10.1016/j.jacl.2015.01.009
   Naghdi A, 2022, J CARDIOVASC THORAC, V14, P128, DOI 10.34172/jcvtr.2022.23
   Rodrigues HCN, 2021, CLIN NUTR ESPEN, V44, P136, DOI 10.1016/j.clnesp.2021.06.006
   Noubiap JJ, 2022, DIABETES RES CLIN PR, V188, DOI 10.1016/j.diabres.2022.109924
   Osali A, 2020, DIABETOL METAB SYNDR, V12, DOI 10.1186/s13098-020-00532-4
   Peng Y, 2021, DRUG DES DEV THER, V15, P4503, DOI 10.2147/DDDT.S327378
   Porro C, 2023, MOLECULES, V28, DOI 10.3390/molecules28052418
   Pratyush Daliparthy Devi, 2012, Indian J Endocrinol Metab, V16, P112, DOI 10.4103/2230-8210.91205
   Qiu LJ, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1216708
   Rahimi HR, 2016, AVICENNA J PHYTOMEDI, V6, P567
   Rezaei M, 2024, BMC NUTR, V10, DOI 10.1186/s40795-024-00877-3
   Salehi B, 2020, J CLIN MED, V9, DOI 10.3390/jcm9030746
   Sathyabhama M, 2022, BIOMOLECULES, V12, DOI 10.3390/biom12101405
   Sedighiyan M, 2022, BMC RES NOTES, V15, DOI 10.1186/s13104-022-06074-4
   Shafabakhsh R, 2020, IRAN J KIDNEY DIS, V14, P290
   Sherwani SI, 2016, BIOMARK INSIGHTS, V11, P95, DOI [10.4137/BMI.S38440, 10.4137/BMIMI.S38440]
   Sinha B, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-72967-8
   Soltani M, 2024, TRIALS, V25, DOI 10.1186/s13063-024-08354-9
   Stanciu S, 2023, METABOLITES, V13, DOI 10.3390/metabo13010087
   Sterne JAC, 2011, BMJ-BRIT MED J, V343, DOI 10.1136/bmj.d4002
   Sun Q, 2024, J FUNCT FOODS, V122, DOI 10.1016/j.jff.2024.106476
   Sun Z, 2023, CRIT REV FOOD SCI, V63, P9282, DOI 10.1080/10408398.2022.2067826
   Syukri M, 2020, DIABETES METAB SYND, V14, P2069, DOI 10.1016/j.dsx.2020.10.019
   Thota RN, 2019, LIPIDS HEALTH DIS, V18, DOI 10.1186/s12944-019-0967-x
   Tirandi A, 2022, EUR J CLIN INVEST, V52, DOI 10.1111/eci.13693
   Vafadar-Afshar G, 2021, HEMODIAL INT, V25, P232, DOI 10.1111/hdi.12911
   Varaprasad K., 2024, Nano-Struct. Nano-Objects, V40, DOI [10.1016/j.nanoso.2024.101352, DOI 10.1016/J.NANOSO.2024.101352]
   Zhang TQ, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/4471944
   Zou TD, 2021, NUTRITION, V90, DOI 10.1016/j.nut.2021.111263
NR 79
TC 1
Z9 1
U1 1
U2 1
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD MAR
PY 2025
VL 213
AR 107641
DI 10.1016/j.phrs.2025.107641
EA FEB 2025
PG 20
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA W6H3T
UT WOS:001419557800001
PM 39894187
OA hybrid
DA 2025-06-11
ER

PT J
AU Goutzourelas, N
   Orfanou, M
   Charizanis, I
   Leon, G
   Spandidos, DA
   Kouretas, D
AF Goutzourelas, Nikolaos
   Orfanou, Marina
   Charizanis, Ioannis
   Leon, George
   Spandidos, Demetrios A.
   Kouretas, Demetrios
TI GSH levels affect weight loss in individuals with metabolic syndrome and
   obesity following dietary therapy
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE metabolic syndrome; obesity; oxidative stress; glutathione; weight loss
ID GLUTATHIONE-S-TRANSFERASE; TYPE-2 DIABETES-MELLITUS; ALPHA-KETOGLUTARATE
   DEHYDROGENASE; OXIDATIVE STRESS; INSULIN-RESISTANCE; LIPID-METABOLISM;
   REDOX STATUS; LIPOIC ACID; EXERCISE; COMPLICATIONS
AB This study examined the effects of redox status markers on metabolic syndrome (MetS) and obesity before and after dietary intervention and exercise for weight loss. A total of 103 adults suffering from MetS and obesity participated in this study and followed a personalized diet plan for 6 months. Body weight, body fat (BF) percentage (BF%), respiratory quotient (RQ) and the redox status markers, reduced glutathione (GSH), thiobarbituric acid reactive substances (TBARS) and protein carbonyls (CARB), were measured twice in each individual, before and after intervention. Dietary intervention resulted in weight loss, a reduction in BF% and a decrease in RQ. The GSH levels were significantly decreased following intervention, while the levels of TBARS and CARB were not affected Based on the initial GSH levels, the patients were divided into 2 groups as follows: The high GSH group (GSH, >3.5 mu mol/g Hb) and the low GSH group (GSH <3.5 mu mol/g Hb). Greater weight and BF loss were observed in patients with high GSH levels. It was observed that patients with MetS and obesity with high GSH values responded better to the dietary therapy, exhibiting more significant changes in weight and BF%. This finding underscores the importance of identifying redox status markers, particularly GSH, in obese patients with MetS. Knowing the levels of GSH may aid in developing a better design of an individualized dietary plan for individuals who wish to lose weight.
C1 [Goutzourelas, Nikolaos; Kouretas, Demetrios] Univ Thessaly, Dept Biochem & Biotechnol, Viopolis 41500, Larissa, Greece.
   [Goutzourelas, Nikolaos; Orfanou, Marina; Leon, George] Eatwalk IKE, Athens 15124, Greece.
   [Charizanis, Ioannis] Obes Med Ctr, Thessaloniki 55133, Greece.
   [Spandidos, Demetrios A.] Univ Crete, Med Sch, Lab Clin Virol, Iraklion 71409, Greece.
C3 University of Crete
RP Kouretas, D (corresponding author), Univ Thessaly, Dept Biochem & Biotechnol, Viopolis 41500, Larissa, Greece.
EM dkouret@uth.gr
RI KOURETAS, DEMETRIOS/ABE-8519-2020
OI Spandidos, Demetrios/0000-0002-1146-931X
CR Abete I, 2010, NUTR REV, V68, P214, DOI 10.1111/j.1753-4887.2010.00280.x
   Adamo KB, 2012, INT J ENV RES PUB HE, V9, P1263, DOI 10.3390/ijerph9041263
   Ades PA, 2014, PROG CARDIOVASC DIS, V56, P448, DOI 10.1016/j.pcad.2013.09.009
   Akbar S., 2011, The British Journal of Diabetes and Vascular Disease, V11, P62
   Applegate MAB, 2008, BIOCHEMISTRY-US, V47, P473, DOI 10.1021/bi7017464
   Aroor AR, 2014, DIABETES, V63, P2216, DOI 10.2337/db14-0424
   Balkau B, 2002, DIABETES METAB, V28, P364
   Bid HK, 2010, J POSTGRAD MED, V56, P176, DOI 10.4103/0022-3859.68633
   Bloomer RJ, 2008, GENDER MED, V5, P218, DOI 10.1016/j.genm.2008.07.002
   Bouret S, 2015, PHYSIOL REV, V95, P47, DOI 10.1152/physrev.00007.2014
   Bulló M, 2013, CURR VASC PHARMACOL, V11, P928, DOI 10.2174/15701611113116660174
   De Sousa SMC, 2016, BEST PRACT RES CL OB, V37, P140, DOI 10.1016/j.bpobgyn.2016.01.006
   Deponte M, 2013, BBA-GEN SUBJECTS, V1830, P3217, DOI 10.1016/j.bbagen.2012.09.018
   Emili A, 2007, CAN FAM PHYSICIAN, V53, P1203
   Erol A, 2014, LANCET, V384, P853, DOI 10.1016/S0140-6736(14)61486-0
   Felizola SJA., 2015, ResearchGate, DOI DOI 10.13140/RG.2.1.4502.4804
   Ferland A, 2011, CURR HYPERTENS REP, V13, P456, DOI 10.1007/s11906-011-0221-z
   Findeisen HM, 2011, OBESITY, V19, P2429, DOI 10.1038/oby.2011.298
   Folli F, 2011, CURR DIABETES REV, V7, P313, DOI 10.2174/157339911797415585
   Ghosh J, 1998, P NATL ACAD SCI USA, V95, P13182, DOI 10.1073/pnas.95.22.13182
   Giacco F, 2010, CIRC RES, V107, P1058, DOI 10.1161/CIRCRESAHA.110.223545
   GRIFFITH OW, 1979, J BIOL CHEM, V254, P7558
   Ha CY, 2012, CLIN ENDOCRINOL, V76, P674, DOI 10.1111/j.1365-2265.2011.04244.x
   Halliwell B, 2009, FREE RADICAL BIO MED, V46, P531, DOI 10.1016/j.freeradbiomed.2008.11.008
   Hutcheson R, 2012, EXP DIABETES RES, DOI 10.1155/2012/271028
   Jiménez-Osorio AS, 2014, INT J MOL SCI, V15, P20290, DOI 10.3390/ijms151120290
   Jumpertz R, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041503
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Keane D, 2013, CURR VASC PHARMACOL, V11, P842, DOI 10.2174/15701611113116660173
   Keles MS, 2001, CAN J NEUROL SCI, V28, P141, DOI 10.1017/S0317167100052823
   Kendig EL, 2011, TOXICOL APPL PHARM, V257, P338, DOI 10.1016/j.taap.2011.09.017
   Kil IS, 2005, J BIOL CHEM, V280, P10846, DOI 10.1074/jbc.M411306200
   Kolyva AS, 2014, NUTR DIABETES, V4, DOI 10.1038/nutd.2014.34
   Kuzuya M, 2008, AM J CLIN NUTR, V87, P1939, DOI 10.1093/ajcn/87.6.1939
   Lin AH, 2012, J AGR FOOD CHEM, V60, P6537, DOI 10.1021/jf301567m
   Liu XJ, 2014, SCI CHINA LIFE SCI, V57, P729, DOI 10.1007/s11427-014-4668-4
   Matthaiou CM, 2014, FOOD CHEM TOXICOL, V73, P1, DOI 10.1016/j.fct.2014.07.027
   Mazzetti AP, 2015, NEUROCHEM INT, V82, P10, DOI 10.1016/j.neuint.2015.01.008
   McClung JP, 2004, P NATL ACAD SCI USA, V101, P8852, DOI 10.1073/pnas.0308096101
   McLain AL, 2013, FREE RADICAL BIO MED, V61, P161, DOI 10.1016/j.freeradbiomed.2013.03.020
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   Mylonas C, 1999, IN VIVO, V13, P295
   Neyestani TR, 2007, J ENDOCRINOL INVEST, V30, P833, DOI 10.1007/BF03349224
   Nikooyeh B, 2016, DIABETES-METAB RES, V32, P260, DOI 10.1002/dmrr.2718
   Nogiec C, 2015, MOL METAB, V4, P151, DOI 10.1016/j.molmet.2014.12.012
   Orient A, 2007, NEPHROL DIAL TRANSPL, V22, P1281, DOI 10.1093/ndt/gfm077
   Patsoukis N, 2004, NEUROSCI LETT, V357, P83, DOI 10.1016/j.neulet.2003.10.080
   Pérez S, 2015, REDOX BIOL, V5, P1, DOI 10.1016/j.redox.2015.01.014
   Pi JB, 2010, J BIOL CHEM, V285, P9292, DOI 10.1074/jbc.M109.093955
   Picklo MJ, 2015, NUTR REV, V73, P858, DOI 10.1093/nutrit/nuv042
   Reddy Y. N., 2004, Indian Journal of Tuberculosis, V51, P213
   Roberts CK, 2013, COMPR PHYSIOL, V3, P1, DOI 10.1002/cphy.c110062
   Root MM, 2013, INT J VITAM NUTR RES, V83, P224, DOI 10.1024/0300-9831/a000164
   Samaras A, 2014, FOOD CHEM TOXICOL, V69, P231, DOI 10.1016/j.fct.2014.03.029
   Sarma S, 2016, CARDIOL CLIN, V34, P603, DOI 10.1016/j.ccl.2016.06.009
   Scuteri A, 2015, EUR J PREV CARDIOL, V22, P486, DOI 10.1177/2047487314525529
   Seo HA, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/184598
   Shehzad A, 2011, EUR J NUTR, V50, P151, DOI 10.1007/s00394-011-0188-1
   Shibata T, 2011, J BIOL CHEM, V286, P42150, DOI 10.1074/jbc.M111.308049
   Sofer S, 2015, ADV NUTR, V6, P214, DOI 10.3945/an.114.007518
   Spanidis Y, 2016, EXP THER MED, V11, P895, DOI 10.3892/etm.2016.2968
   Spanidis Y, 2015, IN VIVO, V29, P595
   Stagos D, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/204615
   Strasser B, 2013, ANN NY ACAD SCI, V1281, P141, DOI 10.1111/j.1749-6632.2012.06785.x
   Sutin AR, 2010, AGE, V32, P513, DOI 10.1007/s11357-010-9153-9
   Tang ST, 2013, GENE, V530, P301, DOI 10.1016/j.gene.2013.08.043
   Thangavel N, 2017, INT J MED CHEM, V2017, DOI 10.1155/2017/1069718
   Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
   Vomhof-DeKrey EE, 2012, J NUTR BIOCHEM, V23, P1201, DOI 10.1016/j.jnutbio.2012.03.005
   Wang XD, 2008, DIABETOLOGIA, V51, P1515, DOI 10.1007/s00125-008-1055-3
   Wang XD, 2011, ANTIOXID REDOX SIGN, V14, P391, DOI 10.1089/ars.2010.3302
   Watson JD, 2014, LANCET, V383, P841, DOI 10.1016/S0140-6736(13)62365-X
   Wikner C, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061763
   Wilson PWF, 2003, CIRCULATION, V108, P1422, DOI 10.1161/01.CIR.0000089505.34741.E5
NR 74
TC 18
Z9 23
U1 0
U2 0
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD AUG
PY 2018
VL 16
IS 2
BP 635
EP 642
DI 10.3892/etm.2018.6204
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GR1GO
UT WOS:000442280500023
PM 30116319
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Aguilera-Méndez, A
   Alvarez-Delgado, C
   Hernández-Godinez, D
   Fernandez-Mejia, C
AF Aguilera-Mendez, Asdrubal
   Alvarez-Delgado, Carolina
   Hernandez-Godinez, Daniel
   Fernandez-Mejia, Cristina
TI Hepatic Diseases Related to Triglyceride Metabolism
SO MINI-REVIEWS IN MEDICINAL CHEMISTRY
LA English
DT Review
DE Hepatic disease; inflammation; insulin resistance; liver; metabolism;
   triglycerides
ID FATTY LIVER-DISEASE; ENDOPLASMIC-RETICULUM STRESS; NONALCOHOLIC
   STEATOHEPATITIS; HEPATOCELLULAR-CARCINOMA; GUT MICROBIOTA; RISK-FACTORS;
   PROTEIN; MECHANISMS; STEATOSIS; ACTIVATION
AB Triglycerides participate in key metabolic functions such as energy storage, thermal insulation and as deposit for essential and non-essential fatty acids that can be used as precursors for the synthesis of structural and functional phospholipids. The liver is a central organ in the regulation of triglyceride metabolism, and it participates in triglyceride synthesis, export, uptake and oxidation. The metabolic syndrome and associated diseases are among the main concerns of public health worldwide. One of the metabolic syndrome components is impaired triglyceride metabolism. Diseases associated with the metabolic syndrome promote the appearance of hepatic alterations e. g., non-alcoholic steatosis, steatohepatitis, fibrosis, cirrhosis and cancer. In this article, we review the molecular actions involved in impaired triglyceride metabolism and its association with hepatic diseases. We discuss mechanisms that reconcile the chronic inflammation and insulin resistance, and new concepts on the role of intestinal micro-flora permeability and proliferation in fatty liver etiology. We also describe the participation of oxidative stress in the progression of events leading from steatosis to steatohepatitis and fibrosis. Finally, we provide information regarding the mechanisms that link fatty acid accumulation during steatosis with changes in growth factors and cytokines that lead to the development of neoplastic cells. One of the main medical concerns vis-a-vis hepatic diseases is the lack of symptoms at the onset of the illness and, as result, its late diagnosis. The understandings of the molecular mechanisms that underlie hepatic diseases could help design strategies towards establishing markers for their accurate and timely diagnosis.
C1 [Aguilera-Mendez, Asdrubal; Hernandez-Godinez, Daniel] Univ Michoacana, Morelia 58030, Michoacan, Mexico.
   [Aguilera-Mendez, Asdrubal; Alvarez-Delgado, Carolina; Fernandez-Mejia, Cristina] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Unidad Genet Nutr, Inst Nacl Pediat, Mexico City 04530, DF, Mexico.
C3 Universidad Michoacana de San Nicolas de Hidalgo; Universidad Nacional
   Autonoma de Mexico
RP Fernandez-Mejia, C (corresponding author), Univ Nacl Autonoma Mexico, Inst Invest Biomed, Unidad Genet Nutr, Inst Nacl Pediat, Av Iman 1,Cuarto Piso, Mexico City 04530, DF, Mexico.
EM crisfern@biomedicas.unam.mx
RI Aguilera-Méndez, Asdrubal/AAG-4797-2020; Alvarez-Delgado,
   Carolina/B-8195-2015
OI Aguilera Mendez, Asdrubal/0000-0003-0326-2068; Alvarez-Delgado,
   Carolina/0000-0002-4567-1081
FU Consejo Nacional de Ciencia y Tecnologia [99294-M]; Direccion General de
   Asuntos del Personal Academico, Universidad Nacional Autonoma de Mexico
   [IN214811]; CONACYT [99294-M, CVU/Becario 91634]; PROMEP [UMSNH-208];
   Instituto de Ciencia y Tecnologia del Distrito Federal (ICyTDF)
   [ICYTDF/SRI/PB/4/2012]
FX Supported by a research grant from the Consejo Nacional de Ciencia y
   Tecnologia 99294-M, the Direccion General de Asuntos del Personal
   Academico, Universidad Nacional Autonoma de Mexico IN214811. Asdrubal
   Aguilera is recipient of the CONACYT and PROMEP scholarship number
   CVU/Becario 91634 and UMSNH-208 respectively. Carolina Alvarez-Delgado
   is a recipient of a postdoctoral fellowship stipend from CONACyT
   (99294-M) and from the Instituto de Ciencia y Tecnologia del Distrito
   Federal (ICyTDF), fellowship: ICYTDF/SRI/PB/4/2012. We acknowledge that
   the authors Asdrubal Aguilera-Mendez, Carolina Alvarez-Delgado, Daniel
   Hernandez-Godinez and Cristina Fernandez-Mejia have no financial
   interest or other contractual agreements that might cause conflicts of
   interest or be perceived as causing conflicts of interest in any company
   or organization sponsoring the research.
CR Adams LA, 2006, POSTGRAD MED J, V82, P315, DOI 10.1136/pgmj.2005.042200
   Albano E, 2005, GUT, V54, P987, DOI 10.1136/gut.2004.057968
   Almeda-Valdés P, 2009, ANN HEPATOL, V8, pS18, DOI 10.1016/S1665-2681(19)31822-8
   Angulo P, 2002, J GASTROEN HEPATOL, V17, pS186, DOI 10.1046/j.1440-1746.17.s1.10.x
   Ankoma-Sey V, 1999, NEWS PHYSIOL SCI, V14, P149
   [Anonymous], 2011, NATL VITAL STAT REP
   Aravalli RN, 2013, ARCH TOXICOL, V87, P227, DOI 10.1007/s00204-012-0931-2
   Avramoglu RK, 2006, CLIN CHIM ACTA, V368, P1, DOI 10.1016/j.cca.2005.12.026
   Bäckhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Bell SJ, 1997, J AM DIET ASSOC, V97, P280, DOI 10.1016/S0002-8223(97)00072-2
   Borena W, 2012, INT J CANCER, V131, P193, DOI 10.1002/ijc.26338
   Campos E, 2013, MED INT MEX, V29, P20
   Cazanave SC, 2010, CLIN LIPIDOL, V5, P71, DOI 10.2217/CLP.09.85
   Cichoz-Lach H, 2010, J PHYSIOL PHARMACOL, V61, P577
   Coleman RA, 2004, PROG LIPID RES, V43, P134, DOI 10.1016/S0163-7827(03)00051-1
   Cortez-Pinto H, 1999, JAMA-J AM MED ASSOC, V282, P1659, DOI 10.1001/jama.282.17.1659
   Cortez-Pinto H, 2006, J HEPATOL, V44, P197, DOI 10.1016/j.jhep.2005.09.002
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   Souza Mônica Rodrigues de Araújo, 2012, Arq. Gastroenterol., V49, P89, DOI 10.1590/S0004-28032012000100015
   DRENICK EJ, 1982, GASTROENTEROLOGY, V82, P535
   Du T, 2011, FREE RADICAL BIO MED, V51, P2060, DOI 10.1016/j.freeradbiomed.2011.09.006
   Duvnjak M, 2007, WORLD J GASTROENTERO, V13, P4539, DOI 10.3748/wjg.v13.i34.4539
   Edmison John, 2007, Clin Liver Dis, V11, P75, DOI 10.1016/j.cld.2007.02.011
   Fausto N, 2006, HEPATOLOGY, V43, pS45, DOI 10.1002/hep.20969
   Ferré P, 2010, DIABETES OBES METAB, V12, P83, DOI 10.1111/j.1463-1326.2010.01275.x
   Ganji A., 2011, MIDDLE E J DIG DIS, V1, P56
   Garcia-Tsao G, 2010, HEPATOLOGY, V51, P1445, DOI 10.1002/hep.23478
   Iwaisako K, 2012, J GASTROEN HEPATOL, V27, P65, DOI 10.1111/j.1440-1746.2011.07002.x
   Jaeschke H, 2006, AM J PHYSIOL-GASTR L, V290, pG1083, DOI 10.1152/ajpgi.00568.2005
   Jump DB, 2005, J NUTR, V135, P2503, DOI 10.1093/jn/135.11.2503
   Koek GH, 2011, CLIN CHIM ACTA, V412, P1297, DOI 10.1016/j.cca.2011.04.013
   Larter CZ, 2008, J GASTROEN HEPATOL, V23, P267, DOI 10.1111/j.1440-1746.2007.05157.x
   Lettéron P, 2003, HEPATOLOGY, V38, P133, DOI 10.1053/jhep.2003.50309
   Lin SB, 2006, MOL ENDOCRINOL, V20, P3376, DOI 10.1210/me.2006-0177
   Lonardo A, 2004, GASTROENTEROLOGY, V126, P586, DOI 10.1053/j.gastro.2003.11.020
   Machado MV, 2012, ANN HEPATOL, V11, P440, DOI 10.1016/S1665-2681(19)31457-7
   MAHER JJ, 1988, J CLIN INVEST, V82, P450, DOI 10.1172/JCI113618
   Marchesini G, 2005, CURR OPIN LIPIDOL, V16, P421, DOI 10.1097/01.mol.0000174153.53683.f2
   Marra F, 2005, Eur Rev Med Pharmacol Sci, V9, P279
   Marra F, 2008, TRENDS MOL MED, V14, P72, DOI 10.1016/j.molmed.2007.12.003
   Musso G, 2011, ANN MED, V43, P617, DOI 10.3109/07853890.2010.518623
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Paredes AH, 2012, CLIN LIVER DIS, V16, P397, DOI 10.1016/j.cld.2012.03.005
   Park EJ, 2010, CELL, V140, P197, DOI 10.1016/j.cell.2009.12.052
   Paschos P, 2009, HIPPOKRATIA, V13, P9
   PIJLS KE, 2013, LIVER INT
   Pircalaboiu Lucretia, 2010, Rom J Intern Med, V48, P193
   Puri P, 2008, GASTROENTEROLOGY, V134, P568, DOI 10.1053/j.gastro.2007.10.039
   Reddy JK, 2006, AM J PHYSIOL-GASTR L, V290, pG852, DOI 10.1152/ajpgi.00521.2005
   Rippe RA, 2004, GASTROENTEROLOGY, V127, P1260, DOI 10.1053/j.gastro.2004.08.028
   ROBERTS E, 2008, NONALCOHOLIC STEATOS, P253
   Saadeh S, 2002, GASTROENTEROLOGY, V123, P745, DOI 10.1053/gast.2002.35354
   Sánchez A, 2004, HEPATOLOGY, V39, P376, DOI 10.1002/hep.20040
   Sánchez DM, 2005, MED CLIN-BARCELONA, V125, P108, DOI 10.1157/13076737
   Schreuder TCMA, 2008, WORLD J GASTROENTERO, V14, P2474, DOI 10.3748/wjg.14.2474
   Sohrabpour AA, 2012, ALIMENT PHARM THER, V36, P824, DOI 10.1111/apt.12044
   Srivastava SK, 2011, CHEM-BIOL INTERACT, V191, P330, DOI 10.1016/j.cbi.2011.02.023
   Starley BQ, 2010, HEPATOLOGY, V51, P1820, DOI 10.1002/hep.23594
   Tarantino G, 2007, J GASTROEN HEPATOL, V22, P293, DOI 10.1111/j.1440-1746.2007.04824.x
   Targher G, 2010, J HEPATOL, V53, P713, DOI 10.1016/j.jhep.2010.04.030
   Vacca M, 2011, WIRES SYST BIOL MED, V3, P562, DOI 10.1002/wsbm.137
   Vernon G, 2011, ALIMENT PHARM THER, V34, P274, DOI 10.1111/j.1365-2036.2011.04724.x
   Wang D, 2006, ENDOCRINOLOGY, V147, P943, DOI 10.1210/en.2005-0570
   White DL, 2012, CLIN GASTROENTEROL H, V10, P1342, DOI 10.1016/j.cgh.2012.10.001
   Yilmaz Y, 2012, ALIMENT PHARM THER, V36, P815, DOI 10.1111/apt.12046
   Yoshimoto S, 2013, NATURE, V499, P97, DOI 10.1038/nature12347
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI13505
NR 67
TC 14
Z9 14
U1 1
U2 27
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-5575
EI 1875-5607
J9 MINI-REV MED CHEM
JI Mini-Rev. Med. Chem.
PD OCT
PY 2013
VL 13
IS 12
BP 1691
EP 1699
PG 9
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 220IR
UT WOS:000324576900001
PM 24059726
DA 2025-06-11
ER

PT J
AU Mainini, G
   Ercolano, S
   De Simone, R
   Iavarone, I
   Lizza, R
   Passaro, M
AF Mainini, Giampaolo
   Ercolano, Salvatore
   De Simone, Raffaella
   Iavarone, Irene
   Lizza, Rosalia
   Passaro, Mario
TI Dietary Supplementation of Myo-Inositol, Cocoa Polyphenols, and Soy
   Isoflavones Improves Vasomotor Symptoms and Metabolic Profile in
   Menopausal Women with Metabolic Syndrome: A Retrospective Clinical Study
SO MEDICINA-LITHUANIA
LA English
DT Article
DE menopause; metabolic syndrome; vasomotor symptoms; myo-Inositol; cocoa
   polyphenols; soy isoflavones
ID POSTMENOPAUSAL WOMEN; BLOOD-PRESSURE; PREVENTION; MANAGEMENT; HORMONE;
   DISEASE; HEALTH
AB Background and Objectives: Hormonal changes physiologically occurring in menopausal women may increase the risk of developing metabolic and vasomotor disturbances, which contribute to increase the risk of developing other concomitant pathologies, such as metabolic syndrome (MetS). Materials and Methods: Retrospective data from 200 menopausal women with MetS and vasomotor symptoms taking one sachet per day of the dietary supplement INOFOLIC (R) NRT (Farmares srl, Rome, Italy) were collected. Each sachet consisted of myo-Inositol (2000 mg), cocoa polyphenols (30 mg), and soy isoflavones (80 mg, of which 50 mg is genistin). Patients recorded their symptoms through a medical questionnaire at the beginning of the administration (T0) and after 6 months (T1). Results: We observed an improvement in both the frequency and the severity of hot flushes: increased percentage of 2-3 hot flushes (28 at T0 vs. 65% at T1, p value < 0.001) and decreased percentage of 4-9 hot flushes (54% at T0 vs. 18% at T1, p value < 0.001). Moreover, symptoms of depression improved after supplementation (87% at T0 vs. 56% at T1 of patients reported moderate depression symptoms, p value < 0.001). Regarding metabolic profile, women improved body mass index and waist circumference with a reduction in the percentage of overweight and obesity women (88% at T0 vs. 51% at T1, p value = 0.01; 14% at T0 vs. 9% at T1, p value = 0.04). In addition, the number of women suffering from non-insulin dependent diabetes reduced (26% at T0 vs. 16% at T1, p value = 0.04). Conclusions: These data corroborate previously observed beneficial effects of the oral administration of myo-Inositol, cocoa polyphenols, and soy isoflavones against menopausal symptoms in the study population. Considering the promising results of the present study, further prospective controlled clinical trials are needed to deeply understand and support the efficacy of these natural compounds for the management of menopausal symptoms.
C1 [Mainini, Giampaolo; Ercolano, Salvatore; De Simone, Raffaella; Iavarone, Irene; Lizza, Rosalia; Passaro, Mario] Soc Campano Calabro Apulo Lucana Ginecol Ostetrici, I-80133 Naples, Italy.
RP Mainini, G (corresponding author), Soc Campano Calabro Apulo Lucana Ginecol Ostetrici, I-80133 Naples, Italy.
EM giampaolomainini@libero.it
RI Iavarone, Irene/JQP-0981-2023
OI Iavarone, Irene/0000-0003-3057-661X
FU Farmares s.r.l, Rome, Italy
FX No Statement Available
CR Agrinier N, 2010, MATURITAS, V65, P237, DOI 10.1016/j.maturitas.2009.11.023
   Avis NE, 2015, JAMA INTERN MED, V175, P531, DOI 10.1001/jamainternmed.2014.8063
   Bevilacqua A, 2018, INT J ENDOCRINOL, V2018, DOI 10.1155/2018/1968450
   Chaimani A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076654
   Chen LR, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22063212
   D'Anna R, 2014, INT J ENDOCRINOL, V2014, DOI 10.1155/2014/653561
   Dennerstein L, 2007, HUM REPROD UPDATE, V13, P551, DOI 10.1093/humupd/dmm022
   El Khoudary SR, 2018, ARTERIOSCL THROM VAS, V38, P2236, DOI 10.1161/ATVBAHA.118.311017
   Garcia-Yu IA, 2022, NUTR NEUROSCI, V25, P1147, DOI 10.1080/1028415X.2020.1840119
   Garcia-Yu IA, 2021, BRIT J NUTR, V125, P548, DOI 10.1017/S0007114520003086
   Garcia-Yu IA, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2018-024095
   Giordano D, 2011, MENOPAUSE, V18, P102, DOI 10.1097/gme.0b013e3181e8e1b1
   Grady D, 2006, NEW ENGL J MED, V355, P2338, DOI 10.1056/NEJMcp054015
   Grassi D, 2005, HYPERTENSION, V46, P398, DOI 10.1161/01.HYP.0000174990.46027.70
   Grassi D, 2005, AM J CLIN NUTR, V81, P611
   Irum N, 2023, FRONT BEHAV NEUROSCI, V17, DOI 10.3389/fnbeh.2023.1185522
   Islam MA, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/5137431
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jaimez RE, 2022, PEERJ, V10, DOI 10.7717/peerj.12676
   Johnson A, 2019, J EVID-BASED INTEGR, V24, DOI 10.1177/2515690X19829380
   Kwon SH, 2007, INT J PHARMACEUT, V337, P148, DOI 10.1016/j.ijpharm.2006.12.046
   Limbana T, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.9966
   Liu ZM, 2013, J OBES, V2013, DOI 10.1155/2013/359763
   Lobo RA, 2014, CLIMACTERIC, V17, P540, DOI 10.3109/13697137.2014.933411
   Ma J, 2006, MENOPAUSE, V13, P506, DOI 10.1097/01.gme.0000179047.00748.53
   Maclennan A H, 2004, Cochrane Database Syst Rev, pCD002978, DOI 10.1002/14651858.CD002978.pub2
   Mehta J, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.564781
   Okamoto T, 2016, CLIN INTERV AGING, V11, P1645, DOI 10.2147/CIA.S118152
   Peacock K., 2018, Menopause
   Pintova S, 2019, CANCER CHEMOTH PHARM, V84, P591, DOI 10.1007/s00280-019-03886-3
   Posadzki P, 2013, MATURITAS, V75, P34, DOI 10.1016/j.maturitas.2013.02.005
   Rossouw JE, 2002, JAMA-J AM MED ASSOC, V288, P321, DOI 10.1001/jama.288.3.321
   Santamaria A, 2012, CLIMACTERIC, V15, P490, DOI 10.3109/13697137.2011.631063
   Santoro N, 2015, ENDOCRIN METAB CLIN, V44, P497, DOI 10.1016/j.ecl.2015.05.001
   Sarri G, 2015, BMJ-BRIT MED J, V351, DOI 10.1136/bmj.h5746
   Sathyapalan T, 2018, NUTR METAB CARDIOVAS, V28, P691, DOI 10.1016/j.numecd.2018.03.007
   Sobenin IA, 2016, CURR PHARM DESIGN, V22, P152, DOI 10.2174/1381612822666151112150520
   Sorrenti V, 2020, NUTRIENTS, V12, DOI 10.3390/nu12071908
   Su BYW, 2018, J ALTERN COMPLEM MED, V24, P850, DOI 10.1089/acm.2017.0118
   Sussman M, 2015, BMC WOMENS HEALTH, V15, DOI 10.1186/s12905-015-0217-y
   Taechakraichana Nimit, 2002, Journal of the Medical Association of Thailand, V85, pS1
   Takahashi TA, 2015, MED CLIN N AM, V99, P521, DOI 10.1016/j.mcna.2015.01.006
   Tangney CC, 2013, CURR ATHEROSCLER REP, V15, DOI 10.1007/s11883-013-0324-x
   Thangavel P, 2019, MOLECULES, V24, DOI 10.3390/molecules24213892
   Thurston RC, 2008, CIRCULATION, V118, P1234, DOI 10.1161/CIRCULATIONAHA.108.776823
   Utian Wulf H, 2005, Health Qual Life Outcomes, V3, P47, DOI 10.1186/1477-7525-3-47
   Wang L, 2021, FOOD FUNCT, V12, P4995, DOI [10.1039/d0fo03254a, 10.1039/D0FO03254A]
   Whelton PK, 2018, J AM COLL CARDIOL, V71, pE127, DOI 10.1016/j.jacc.2017.11.006
   Yang R, 2021, EUR J NUTR, V60, P2155, DOI 10.1007/s00394-020-02403-0
   Yu LD, 2021, NUTRIENTS, V13, DOI 10.3390/nu13093048
   Zaw JJT, 2018, AGEING RES REV, V48, P79, DOI 10.1016/j.arr.2018.10.005
   Zhu DS, 2020, AM J OBSTET GYNECOL, V223, DOI 10.1016/j.ajog.2020.06.039
NR 52
TC 3
Z9 3
U1 1
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD APR
PY 2024
VL 60
IS 4
AR 598
DI 10.3390/medicina60040598
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA PA0W2
UT WOS:001211251700001
PM 38674244
OA gold
DA 2025-06-11
ER

PT J
AU Thaker, PH
   Sood, AK
   Ramondetta, LM
AF Thaker, Premal H.
   Sood, Anil K.
   Ramondetta, Lois M.
TI Importance of adrenergic pathways in women's cancers
SO CANCER BIOMARKERS
LA English
DT Article
DE Gynecologic malignancies; adrenergic pathways; ovarian cancer;
   endometrial cancer; cervical cancer
ID ENDOTHELIAL GROWTH-FACTOR; SQUAMOUS-CELL CARCINOMA;
   POLYCYSTIC-OVARY-SYNDROME; CERVICAL-CANCER; TUMOR ANGIOGENESIS;
   UP-REGULATION; METABOLIC SYNDROME; SOCIAL SUPPORT; CHRONIC STRESS;
   RISK-FACTORS
AB The importance of adrenergic pathways in cancer has long been suspected, but now there is mounting epidemiological, preclinical, and clinical evidence of its importance in gynecologic cancers. To date, most of these effects are mediated primarily through the beta 2 adrenergic receptor activation of the tumor cell cyclic AMP-protein kinase A signaling pathway. This review will discuss the current knowledge about the neuroendocrine stress response in gynecologic tumor biology.
C1 [Thaker, Premal H.] Washington Univ, Sch Med, St Louis, MO USA.
   [Sood, Anil K.; Ramondetta, Lois M.] Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol, Houston, TX 77030 USA.
   [Sood, Anil K.] Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA.
   [Sood, Anil K.] Univ Texas MD Anderson Canc Ctr, Ctr RNA Interference & Noncoding RNA, Houston, TX 77030 USA.
C3 Washington University (WUSTL); University of Texas System; UTMD Anderson
   Cancer Center; University of Texas System; UTMD Anderson Cancer Center;
   University of Texas System; UTMD Anderson Cancer Center
RP Ramondetta, LM (corresponding author), Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol, 1155 Herman Pressler Unit 1362, Houston, TX 77030 USA.
EM thakerp@wudosis.wustl.edu; lramonde@mdanderson.org
FU National Institutes of Health [CA109298, CA140933-01, P50 CA083639, P50
   CA098258, U54 CA151668]
FX Financial support was provided by the National Institutes of Health
   (CA109298, CA140933-01, P50 CA083639, P50 CA098258, U54 CA151668).
CR AGUADO LI, 1982, ENDOCRINOLOGY, V110, P1124, DOI 10.1210/endo-110-4-1124
   Al-Wadei HAN, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0029915
   Al-Wadei MH, 2012, MOL CANCER RES, V10, P239, DOI 10.1158/1541-7786.MCR-11-0332
   Antoni MH, 2006, NAT REV CANCER, V6, P240, DOI 10.1038/nrc1820
   Bancroft CC, 2001, CLIN CANCER RES, V7, P435
   BARRIA A, 1993, ENDOCRINOLOGY, V133, P2696, DOI 10.1210/en.133.6.2696
   Benson S, 2009, PSYCHONEUROENDOCRINO, V34, P727, DOI 10.1016/j.psyneuen.2008.12.001
   Bermúdez-Morales VH, 2011, MOL MED REP, V4, P369, DOI 10.3892/mmr.2011.429
   Bleil ME, 2012, MENOPAUSE
   Botting SK, 2010, TRANSL ONCOL, V3, P170, DOI 10.1593/tlo.09292
   Breen KM, 2006, FRONT NEUROENDOCRIN, V27, P233, DOI 10.1016/j.yfrne.2006.03.335
   Carrasco GA, 2003, EUR J PHARMACOL, V463, P235, DOI 10.1016/S0014-2999(03)01285-8
   Chen JJW, 2003, CLIN CANCER RES, V9, P729
   Chittenden BG, 2009, REPROD BIOMED ONLINE, V19, P398, DOI 10.1016/S1472-6483(10)60175-7
   Chrousos GP, 2009, NAT REV ENDOCRINOL, V5, P374, DOI 10.1038/nrendo.2009.106
   Clere N, 2007, EXP CELL RES, V313, P3239, DOI 10.1016/j.yexcr.2007.06.029
   Coker AL, 2003, PSYCHOSOM MED, V65, P644, DOI 10.1097/01.PSY.0000041471.57895.08
   Cole SW, 2012, CLIN CANCER RES, V18, P1201, DOI 10.1158/1078-0432.CCR-11-0641
   Cooper RA, 1999, BRIT J CANCER, V81, P354, DOI 10.1038/sj.bjc.6690700
   Cooper RA, 1998, CLIN CANCER RES, V4, P2795
   Cramer DW, 2012, HEMATOL ONCOL CLIN N, V26, P1, DOI 10.1016/j.hoc.2011.10.009
   Curtin NM, 2009, BRAIN BEHAV IMMUN, V23, P371, DOI 10.1016/j.bbi.2008.12.010
   D'Albora H, 2002, MICROSC RES TECHNIQ, V59, P484, DOI 10.1002/jemt.10231
   De Punzio C, 1998, EUR J GYNAECOL ONCOL, V19, P287
   de Rooij J, 1998, NATURE, V396, P474, DOI 10.1038/24884
   Diamanti-Kandarakis E, 2006, ANN NY ACAD SCI, V1083, P54, DOI 10.1196/annals.1367.006
   Diaz E, 2011, GYNECOL ONCOL, V120, pS2
   Dinh TV, 1996, OBSTET GYNECOL, V87, P751, DOI 10.1016/0029-7844(96)00039-7
   Dugan LL, 1999, J BIOL CHEM, V274, P25842, DOI 10.1074/jbc.274.36.25842
   EUSTACE D, 1993, GYNECOL ONCOL, V50, P15, DOI 10.1006/gyno.1993.1156
   Friedenreich CM, 2011, CANCER EPIDEM BIOMAR, V20, P2384, DOI 10.1158/1055-9965.EPI-11-0715
   Fujimoto J, 2000, CANCER RES, V60, P2632
   Gaffney DK, 2003, INT J RADIAT ONCOL, V56, P922, DOI 10.1016/S0360-3016(03)00209-8
   Glaser R, 2005, NAT REV IMMUNOL, V5, P243, DOI 10.1038/nri1571
   Glaser R, 2005, BRAIN BEHAV IMMUN, V19, P91, DOI 10.1016/j.bbi.2004.09.001
   Harlow BL, 1998, CANCER EPIDEM BIOMAR, V7, P697
   Hunn J, 2012, CLIN OBSTET GYNECOL, V55, P3, DOI 10.1097/GRF.0b013e31824b4611
   Iwamoto I, 2003, OBSTET GYNECOL, V102, P506, DOI 10.1016/S0029-7844(03)00578-7
   Jensen KE, 2012, CANC EPIDEMIOL BIOMA
   Jensen SE, 2007, BRAIN BEHAV IMMUN, V21, P758, DOI 10.1016/j.bbi.2007.01.003
   Kalantaridou SN, 2004, J REPROD IMMUNOL, V62, P61, DOI 10.1016/j.jri.2003.09.004
   Kim YH, 2010, GYNECOL ONCOL, V119, P232, DOI 10.1016/j.ygyno.2010.07.035
   Kuo LE, 2008, ANN NY ACAD SCI, V1148, P232, DOI 10.1196/annals.1410.035
   Lambert GW, 2010, PHARMACOL THERAPEUT, V126, P159, DOI 10.1016/j.pharmthera.2010.02.002
   Landen CN, 2007, CANCER RES, V67, P10389, DOI 10.1158/0008-5472.CAN-07-0858
   Lane D, 2005, AM J REPROD IMMUNOL, V53, P153, DOI 10.1111/j.1600-0897.2005.00259.x
   Lee JS, 2003, ANAL QUANT CYTOL, V25, P303
   Li P, 2009, DRUG CHEM TOXICOL, V32, P175, DOI 10.1080/01480540902875253
   Liu X, 2008, J CELL BIOCHEM, V105, P53, DOI 10.1002/jcb.21802
   Lutgendorf SK, 1999, J GERONTOL A-BIOL, V54, pM434, DOI 10.1093/gerona/54.9.M434
   Lutgendorf SK, 2005, BRAIN BEHAV IMMUN, V19, P185, DOI 10.1016/j.bbi.2004.11.003
   Lutgendorf SK, 2003, CLIN CANCER RES, V9, P4514
   Lutgendorf SK, 2002, CANCER-AM CANCER SOC, V95, P808, DOI 10.1002/cncr.10739
   Lutgendorf SK, 2008, CLIN CANCER RES, V14, P6839, DOI 10.1158/1078-0432.CCR-08-0230
   Lutgendorf SK, 2008, J CLIN ONCOL, V26, P4820, DOI 10.1200/JCO.2007.14.1978
   Lutgendorf SK, 2008, BRAIN BEHAV IMMUN, V22, P890, DOI 10.1016/j.bbi.2007.12.012
   Lutgendorf SK, 2012, J CLIN ONCOL, V30, P2885, DOI 10.1200/JCO.2011.39.4411
   Lutgendorf SK, 2011, BRAIN BEHAV IMMUN, V25, P250, DOI 10.1016/j.bbi.2010.10.012
   Lutgendorf SK, 2010, BRAIN BEHAV IMMUN, V24, P1231, DOI 10.1016/j.bbi.2010.06.014
   Lutgendorf SK, 2009, BRAIN BEHAV IMMUN, V23, P176, DOI 10.1016/j.bbi.2008.04.155
   Mackay HJ, 2010, GYNECOL ONCOL, V116, P163, DOI 10.1016/j.ygyno.2009.08.012
   Mathur RS, 2000, AM J REPROD IMMUNOL, V44, P114, DOI 10.1111/j.8755-8920.2000.440207.x
   Mayerhofer A, 1996, ENDOCRINOLOGY, V137, P5662, DOI 10.1210/en.137.12.5662
   Mayerhofer A, 1997, ENDOCRINOLOGY, V138, P3320, DOI 10.1210/en.138.8.3320
   Mayerhofer A, 1998, P NATL ACAD SCI USA, V95, P10990, DOI 10.1073/pnas.95.18.10990
   Miller KD, 2020, CA Cancer J Clin, V70, P7, DOI [10.3322/caac.21590, DOI 10.3322/CAAC.21590]
   Moreno-Smith M, 2011, CLIN CANCER RES, V17, P3649, DOI 10.1158/1078-0432.CCR-10-2441
   Moser C, 2000, CAN J PHYSIOL PHARM, V78, P134, DOI 10.1139/cjpp-78-2-134
   Nelson EL, 2008, CLIN CANCER RES, V14, P2111, DOI 10.1158/1078-0432.CCR-07-1632
   Pal L, 2010, FERTIL STERIL, V93, P1074, DOI 10.1016/j.fertnstert.2008.10.069
   Pereira DB, 2005, PSYCHOSOM MED, V67, P1152
   Salvador S, 2009, INT J GYNECOL CANCER, V19, P58, DOI 10.1111/IGC.0b013e318199009c
   Samir R, 2010, AM J OBSTET GYNECOL, V202, DOI 10.1016/j.ajog.2009.11.034
   Santos IN, 2006, STRESS, V9, P69, DOI 10.1080/10253890600771858
   Shang ZJ, 2009, J ORAL PATHOL MED, V38, P371, DOI 10.1111/j.1600-0714.2008.00691.x
   Shin VY, 2008, TOXICOL APPL PHARM, V233, P254, DOI 10.1016/j.taap.2008.08.012
   Sood AK, 2006, CLIN CANCER RES, V12, P369, DOI 10.1158/1078-0432.CCR-05-1698
   Sood AK, 2010, J CLIN INVEST, V120, P1515, DOI 10.1172/JCI40802
   Srivastava S, 2009, BIOSCI TRENDS, V3, P144
   Storch CH, 2010, BRIT J DERMATOL, V163, P269, DOI 10.1111/j.1365-2133.2010.09848.x
   Takahashi H, 2004, ARCH DERMATOL RES, V296, P74, DOI 10.1007/s00403-004-0478-z
   Thaker PH, 2008, SEMIN CANCER BIOL, V18, P164, DOI 10.1016/j.semcancer.2007.12.005
   Thaker PH, 2006, NAT MED, V12, P939, DOI 10.1038/nm1447
   Tjiong MY, 1999, GYNECOL ONCOL, V73, P285, DOI 10.1006/gyno.1999.5358
   Trials.gov C, 2011, THER TARG STRESS FAC
   Turkson J, 2004, EXPERT OPIN THER TAR, V8, P409, DOI 10.1517/14728222.8.5.409
   Walboomers JMM, 1999, J PATHOL, V189, P12, DOI 10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F
   Wenzel L, 2005, GYNECOL ONCOL, V97, P310, DOI 10.1016/j.ygyno.2005.01.010
   Wright JD, 2006, GYNECOL ONCOL, V103, P489, DOI 10.1016/j.ygyno.2006.03.023
   Wypior G, 2011, J REPROD IMMUNOL, V90, P67, DOI 10.1016/j.jri.2011.04.009
   Xu L, 2000, ONCOL RES, V12, P97, DOI 10.3727/096504001108747567
   ZHOU DH, 1993, ENDOCRINOLOGY, V133, P2523, DOI 10.1210/en.133.6.2523
NR 92
TC 15
Z9 16
U1 0
U2 5
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1574-0153
EI 1875-8592
J9 CANCER BIOMARK
JI Cancer Biomark.
PY 2013
VL 13
IS 3
BP 145
EP 154
DI 10.3233/CBM-130324
PG 10
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 195QQ
UT WOS:000322719100003
PM 23912486
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Reljic, D
   Herrmann, HJ
   Neurath, MF
   Zopf, Y
AF Reljic, Dejan
   Herrmann, Hans J.
   Neurath, Markus F.
   Zopf, Yurdagul
TI Iron Beats Electricity: Resistance Training but Not Whole-Body
   Electromyostimulation Improves Cardiometabolic Health in Obese Metabolic
   Syndrome Patients during Caloric Restriction-A Randomized-Controlled
   Study
SO NUTRIENTS
LA English
DT Article
DE exercise; obesity; fasting; muscle mass; strength training;
   cardiovascular disease; hypertension; electrical stimulation; muscular
   strength; psychological health
ID MUSCLE-FIBER-TYPE; INDIVIDUALIZED NUTRITIONAL SUPPORT; WEIGHT-LOSS
   INTERVENTIONS; HUMAN SKELETAL-MUSCLE; QUALITY-OF-LIFE;
   PHYSICAL-ACTIVITY; SARCOPENIC OBESITY; BLOOD-PRESSURE; PROTEIN
   SUPPLEMENTATION; ENERGY-RESTRICTION
AB Caloric restriction (CR) and exercise are cornerstones in the treatment of obesity and cardiometabolic disorders. Recently, whole body electromyostimulation (WB-EMS) has emerged as a more time-efficient alternative to traditional resistance training (RT). However, the effects of WB-EMS compared to RT on cardiometabolic health in obese metabolic syndrome (MetS) patients performed during CR are still unclear. In total, 118 obese MetS patients (52.7 +/- 11.8 years, BMI: 38.1 +/- 6.9 kg/m(2)) undergoing CR over 12 weeks (aim: -500 kcal deficit/day) were randomly allocated to either WB-EMS, single-set RT (1-RT), 3-set RT (3-RT) or an inactive control group (CON). Primary outcome was MetS severity (MetS z-score). Secondary outcomes were body composition, muscle strength and quality of life (QoL). All groups significantly reduced body weight (similar to 3%) and fat mass (similar to 2.6 kg) but only 1-RT and 3-RT preserved skeletal muscle mass (SMM). All exercise groups increased muscle strength in major muscle groups (20-103%). However, only the two RT-groups improved MetS z-score (1-RT: -1.34, p = 0.003; 3-RT: -2.06, p < 0.001) and QoL (1-RT: +6%, p = 0.027; 3-RT: +12%, p < 0.001), while WB-EMS and CON had no impact on these outcomes. We conclude that traditional RT has superior effects on cardiometabolic health, SMM and QoL in obese MetS patients undergoing CR than WB-EMS.
C1 [Reljic, Dejan; Herrmann, Hans J.; Zopf, Yurdagul] Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, Dept Med 1, Hector Ctr Nutr Exercise & Sports, D-91054 Erlangen, Germany.
   [Reljic, Dejan; Herrmann, Hans J.; Neurath, Markus F.; Zopf, Yurdagul] Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, German Ctr Immunotherapy DZI, D-91054 Erlangen, Germany.
   [Neurath, Markus F.] Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, Dept Med 1, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg;
   University of Erlangen Nuremberg
RP Reljic, D (corresponding author), Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, Dept Med 1, Hector Ctr Nutr Exercise & Sports, D-91054 Erlangen, Germany.; Reljic, D (corresponding author), Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, German Ctr Immunotherapy DZI, D-91054 Erlangen, Germany.
EM dejan.reljic@uk-erlangen.de; hans.herrmann@uk-erlangen.de;
   markus.neurath@uk-erlangen.de; yurdaguel.zopf@uk-erlangen.de
RI Reljic, Dejan/CAG-1377-2022
OI Herrmann, Hans Joachim/0000-0002-3021-8022; Reljic,
   Dejan/0000-0001-8049-1775
FU H.W. & J. Hector Foundation; Manfred Roth Foundation; Research
   Foundation for Medicine at the University Hospital Erlangen
FX This study has been supported by the H.W. & J. Hector Foundation, the
   Manfred Roth Foundation, and Research Foundation for Medicine at the
   University Hospital Erlangen.
CR Al-Nimr Rima Itani, 2019, Journal of Nutrition in Gerontology and Geriatrics, V38, P50, DOI 10.1080/21551197.2018.1544533
   Al-Ozairi E, 2021, J CLIN ENDOCR METAB, V106, P309, DOI 10.1210/clinem/dgaa835
   Andersen RE, 2009, J PHYS ACT HEALTH, V6, P651, DOI 10.1123/jpah.6.5.651
   [Anonymous], 2016, J Sports Res
   [Anonymous], 2017, NEW ENGL J MED
   Baskin KK, 2015, CELL METAB, V21, P237, DOI 10.1016/j.cmet.2014.12.021
   Bosy-Westphal A, 2017, EUR J CLIN NUTR, V71, P1061, DOI 10.1038/ejcn.2017.27
   Bosy-Westphal A, 2009, AM J CLIN NUTR, V90, P993, DOI 10.3945/ajcn.2008.27402
   Brzycki M., 1993, JOPERD, V64, P88, DOI [10.1080/07303084.1993.10606684, DOI 10.1080/07303084.1993.10606684]
   Carels RA, 2008, ANN BEHAV MED, V35, pS43, DOI 10.1016/j.eatbeh.2007.12.003
   Caristia S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12082290
   Chooi YC, 2019, METABOLISM, V92, P6, DOI 10.1016/j.metabol.2018.09.005
   Ciciliot S, 2013, INT J BIOCHEM CELL B, V45, P2191, DOI 10.1016/j.biocel.2013.05.016
   Cioffi I, 2018, J TRANSL MED, V16, DOI 10.1186/s12967-018-1748-4
   Cohen J., 1988, STAT POWER ANAL BEHA, DOI [10.4324/9780203771587, DOI 10.4324/9780203771587]
   Correa-Rodríguez M, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111742
   DeNysschen CA, 2009, J INT SOC SPORT NUTR, V6, DOI 10.1186/1550-2783-6-8
   Dohoney P., 2002, Journal of Exercise Physiology Online, V5, P54, DOI DOI 10.1519/R-15304.1
   Donnelly JE, 2009, MED SCI SPORT EXER, V41, P459, DOI 10.1249/MSS.0b013e3181949333
   Dreibati B., 2010, Annals of Physical and Rehabilitation Medicine, V53, P266, DOI 10.1016/j.rehab.2010.03.004
   Ettehad D, 2016, LANCET, V387, P957, DOI 10.1016/S0140-6736(15)01225-8
   Filipovic A, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.01187
   Filipovic A, 2012, J STRENGTH COND RES, V26, P2600, DOI 10.1519/JSC.0b013e31823f2cd1
   Fisher G, 2017, EUR J APPL PHYSIOL, V117, P1413, DOI 10.1007/s00421-017-3634-9
   Fragala MS, 2015, SPORTS MED, V45, P641, DOI 10.1007/s40279-015-0305-z
   Fritzsche D, 2010, HERZ, V35, P34, DOI 10.1007/s00059-010-3268-8
   Galancho-Reina I, 2019, CARDIOMETABOLIC HLTH, V3, P1
   Galvao DA, 2004, J STRENGTH COND RES, V18, P660
   Garber CE, 2011, MED SCI SPORT EXER, V43, P1334, DOI 10.1249/MSS.0b013e318213fefb
   Gibson AA, 2017, BEHAV SCI, V7, DOI 10.3390/bs7030044
   Gillison FB, 2009, SOC SCI MED, V68, P1700, DOI 10.1016/j.socscimed.2009.02.028
   Goodpaster BH, 2002, OBES RES, V10, P575, DOI 10.1038/oby.2002.78
   Gregory CM, 2005, PHYS THER, V85, P358, DOI 10.1093/ptj/85.4.358
   Grochtdreis T, 2019, EUR J HEALTH ECON, V20, P933, DOI 10.1007/s10198-019-01054-1
   Haraldstad K, 2017, EUR REV AGING PHYS A, V14, DOI 10.1186/s11556-017-0177-3
   Hendrie GA, 2018, NUTRIENTS, V10, DOI 10.3390/nu10020197
   Hernelahti M, 2005, HYPERTENSION, V45, P1019, DOI 10.1161/01.HYP.0000165023.09921.34
   Higgs C, 2016, J PRIM HEALTH CARE, V8, P130, DOI 10.1071/HC15038
   Hsu KJ, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092163
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Hui WS, 2010, EUR J EPIDEMIOL, V25, P375, DOI 10.1007/s10654-010-9459-z
   Jensen B, 2019, OBESITY FACTS, V12, P307, DOI 10.1159/000499607
   Jochem C, 2019, J AM MED DIR ASSOC, V20, P1213, DOI 10.1016/j.jamda.2019.05.015
   Johnson JL, 2007, AM J CARDIOL, V100, P1759, DOI 10.1016/j.amjcard.2007.07.027
   Kemmler W, 2016, OSTEOPOROSIS INT, V27, P3261, DOI 10.1007/s00198-016-3662-z
   Kemmler W, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/9236809
   Kemmler W, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00573
   Kemmler W, 2017, CLIN INTERV AGING, V12, P1503, DOI 10.2147/CIA.S137987
   Kemmler W, 2016, BIOMED RES INT, V2016, DOI 10.1155/2016/9705287
   Kemmler W, 2010, J STRENGTH COND RES, V24, P1880, DOI 10.1519/JSC.0b013e3181ddaeee
   Knox ECL, 2014, EUR J PUBLIC HEALTH, V24, P195, DOI 10.1093/eurpub/ckt060
   Law MR, 2009, BMJ-BRIT MED J, V338, DOI 10.1136/bmj.b1665
   Lonnie M, 2018, NUTRIENTS, V10, DOI 10.3390/nu10030360
   Mann S, 2014, SPORTS MED, V44, P211, DOI 10.1007/s40279-013-0110-5
   Marra M, 2019, CONTRAST MEDIA MOL I, DOI 10.1155/2019/3548284
   Mauvais-Jarvis F, 2020, DIABETES, V69, P1857, DOI 10.2337/dbi19-0023
   Morgan PT, 2020, FRONT NUTR, V7, DOI 10.3389/fnut.2020.569904
   Moroshko I, 2011, OBES REV, V12, P912, DOI 10.1111/j.1467-789X.2011.00915.x
   Morton RW, 2019, J PHYSIOL-LONDON, V597, P4601, DOI 10.1113/JP278056
   Myers J, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071652
   Nascimento MA., 2007, RevBras Med Esporte, V13, p40e, DOI DOI 10.1590/S1517-86922007000100011
   National Strength Conditioning Association, 2012, NSCAS GUID TEST ASS
   Pano-Rodriguez A, 2019, BMC COMPLEM ALTERN M, V19, DOI 10.1186/s12906-019-2485-9
   Petersen A, 2020, METABOLISM, V110, DOI 10.1016/j.metabol.2020.154317
   Ramos JS, 2017, METAB SYNDR RELAT D, V15, P319, DOI 10.1089/met.2017.0042
   Ravelli MN, 2020, FRONT NUTR, V7, DOI 10.3389/fnut.2020.00090
   Reljic D, 2020, J PHYSIOL PHARMACOL, V71, P89, DOI 10.26402/jpp.2020.1.08
   Reljic D, 2016, SCAND J MED SCI SPOR, V26, P507, DOI 10.1111/sms.12485
   Reljic D, 2020, J TRANSL MED, V18, DOI 10.1186/s12967-020-02592-6
   Reynolds JM, 2006, J STRENGTH COND RES, V20, P584, DOI 10.1519/00124278-200608000-00020
   Ross Robert, 2008, Can J Cardiol, V24 Suppl D, p25D
   Sardeli AV, 2018, NUTRIENTS, V10, DOI 10.3390/nu10040423
   Schink K, 2020, EUR J CANCER CARE, V29, DOI 10.1111/ecc.13199
   Schink K, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01808
   Schink K, 2018, BMC CANCER, V18, DOI 10.1186/s12885-018-4790-y
   SIMONEAU JA, 1995, FASEB J, V9, P1091, DOI 10.1096/fasebj.9.11.7649409
   Stöllberger C, 2019, BMJ OPEN SPORT EXERC, V5, DOI 10.1136/bmjsem-2019-000619
   Strasser B, 2011, J OBES, V2011, DOI 10.1155/2011/482564
   Stuart CA, 2013, J CLIN ENDOCR METAB, V98, P2027, DOI 10.1210/jc.2012-3876
   Tholl U, 2016, BLOOD PRESS MONIT, V21, P197, DOI 10.1097/MBP.0000000000000186
   Thompson WR., 2010, ACSM's Guidelines for Exercise Testing and Prescription, V8th
   Tudor-Locke C, 2010, INT J BEHAV NUTR PHY, V7, DOI 10.1186/1479-5868-7-60
   van Buuren F, 2013, CLIN RES CARDIOL, V102, P523, DOI 10.1007/s00392-013-0562-5
   Ward LC, 2012, CURR OPIN CLIN NUTR, V15, P424, DOI 10.1097/MCO.0b013e328356b944
   Weinheimer EM, 2012, J NUTR, V142, P1532, DOI 10.3945/jn.111.153619
   Weiss EP, 2017, MED SCI SPORT EXER, V49, P206, DOI 10.1249/MSS.0000000000001074
   Westcott WL, 2012, CURR SPORT MED REP, V11, P209, DOI 10.1249/JSR.0b013e31825dabb8
   Whelton PK, 2018, J AM COLL CARDIOL, V71, P2275, DOI 10.1016/j.jacc.2018.03.016
   WHO, 2010, SCREENING DONATED BLOOD FOR TRANSFUSION: TRANSMISSIBLE INFECTIONS, P1
   Willert S, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.01012
   Willoughby D, 2018, NUTRIENTS, V10, DOI 10.3390/nu10121876
   Wilson JM, 2012, J STRENGTH COND RES, V26, P1724, DOI 10.1519/JSC.0b013e318234eb6f
   Wirtz N, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.01336
   Wittmann K, 2016, CLIN INTERV AGING, V11, P1697, DOI 10.2147/CIA.S116430
   Yan RH, 2019, HYPERTENS RES, V42, P1561, DOI 10.1038/s41440-019-0281-z
NR 95
TC 15
Z9 15
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2021
VL 13
IS 5
AR 1640
DI 10.3390/nu13051640
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ST3KV
UT WOS:000662347800001
PM 34068089
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jorge, JM
   Golas, A
   Patel, N
   Gonzalvo, JP
   Murr, MM
AF Jorge, Jay M.
   Golas, Adam
   Patel, Niketa
   Gonzalvo, John Paul
   Murr, Michel M.
TI Management of nonalcoholic fatty liver disease and the role of bariatric
   surgery: a brief review for surgeons
SO SURGERY FOR OBESITY AND RELATED DISEASES
LA English
DT Review
DE Liver fibrosis; Cirrhosis; Inflammation; Oxidative stress; Lipid
   metabolism; Lipogenesis; Fatty acid oxidation; Diabetes; Metabolic
   syndrome; Insulin resistance; Insulin sensitivity; Guidelines
ID Y GASTRIC BYPASS; ADVANCED FIBROSIS; OXIDATIVE STRESS; WEIGHT-LOSS;
   STEATOHEPATITIS; PLACEBO; INFLAMMATION; FEATURES; OUTCOMES; NAFLD
AB Nonalcoholic fatty liver disease (NAFLD) is closely linked to the metabolic syndrome and is highly prevalent in bariatric patients. The criterion standard to diagnose NAFLD is a liver biopsy specifically to detect inflammatory changes characteristic of nonalcoholic steatohepatitis. Technologic advancements will improve the accuracy of current noninvasive modalities. Modification of risk factors via food management is important to prevent the progression of NAFLD to nonalcoholic steatohepatitis and cirrhosis. Several clinical trials are underway for pharmacologic treatment of NAFLD; currently the mainstay of treatment is insulin sensitizers and vitamin E. There is strong evidence bariatric surgery improves biochemical and histologic features of NAFLD and therefore, bariatric surgery should be considered as a treatment of NAFLD in patients with obesity. Gastric bypass exhibits antilipogenic, antiinflammatory, antioxidant, and antidiabetic properties in the livers of laboratory animals; thereby, providing a unique window to study regulation of body adiposity and insulin resistance. (C) 2020 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.
C1 [Jorge, Jay M.; Golas, Adam; Patel, Niketa; Gonzalvo, John Paul; Murr, Michel M.] AdventHlth Tampa, Bariatr & Metab Inst, 3000 Med Pk Dr,Suite 490, Tampa, FL 33613 USA.
C3 Adventist Health Services; AdventHealth; (AdventHealth) West Florida
   Division; West Florida Hospital; AdventHealth Tampa
RP Murr, MM (corresponding author), AdventHlth Tampa, Bariatr & Metab Inst, 3000 Med Pk Dr,Suite 490, Tampa, FL 33613 USA.
EM michel.murr@adventhealth.com
RI Patel, Niketa/HTN-6638-2023
OI Patel, Niketa A./0000-0003-4811-8596
CR Angulo P, 2007, HEPATOLOGY, V45, P846, DOI 10.1002/hep.21496
   Bower G, 2015, OBES SURG, V25, P2280, DOI 10.1007/s11695-015-1691-x
   Buzzetti E, 2016, METABOLISM, V65, P1038, DOI 10.1016/j.metabol.2015.12.012
   Carter D, 2018, CLIN LIVER DIS, V22, P213, DOI 10.1016/j.cld.2017.08.015
   Carter G, 2015, BBA CLIN, V4, P102, DOI 10.1016/j.bbacli.2015.09.001
   Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI 10.1002/hep.29367
   Charlton MR, 2011, GASTROENTEROLOGY, V141, P1249, DOI 10.1053/j.gastro.2011.06.061
   Cui J, 2016, J HEPATOL, V65, P369, DOI 10.1016/j.jhep.2016.04.021
   Cusi K, 2014, J HEPATOL, V60, P167, DOI 10.1016/j.jhep.2013.07.042
   Eslam M, 2018, J HEPATOL, V68, P268, DOI 10.1016/j.jhep.2017.09.003
   Ezquerro S, 2020, INT J OBESITY, V44, P475, DOI 10.1038/s41366-019-0420-2
   Fakhry TK, 2019, SURG OBES RELAT DIS, V15, P502, DOI 10.1016/j.soard.2018.12.002
   Guha IN, 2008, HEPATOLOGY, V47, P455, DOI 10.1002/hep.21984
   Loomba R, 2014, HEPATOLOGY, V60, P1920, DOI 10.1002/hep.27362
   McPherson S, 2010, GUT, V59, P1265, DOI 10.1136/gut.2010.216077
   Neuschwander-Tetri BA, 2015, LANCET, V385, P956, DOI 10.1016/S0140-6736(14)61933-4
   Parikh MP, 2019, CLIN LIVER DIS, V23, P363, DOI 10.1016/j.cld.2019.01.001
   Peng Y., 2009, Journal of Surgical Research, V151, P244
   Peng YH, 2017, SURGERY, V162, P59, DOI 10.1016/j.surg.2017.01.012
   Peng YH, 2013, SURG OBES RELAT DIS, V9, P429, DOI 10.1016/j.soard.2011.06.012
   Peng YH, 2012, SURG OBES RELAT DIS, V8, P73, DOI 10.1016/j.soard.2011.07.019
   Peng YH, 2010, J GASTROINTEST SURG, V14, P221, DOI 10.1007/s11605-009-1102-5
   Peng YH, 2009, J GASTROINTEST SURG, V13, P2043, DOI 10.1007/s11605-009-1032-2
   Promrat K, 2010, HEPATOLOGY, V51, P121, DOI 10.1002/hep.23276
   Rideout DA, 2010, SURG OBES RELAT DIS, V6, P676, DOI 10.1016/j.soard.2010.05.017
   Rinella ME, 2015, JAMA-J AM MED ASSOC, V313, P2263, DOI 10.1001/jama.2015.5370
   Sanyal AJ, 2006, HEPATOLOGY, V43, P682, DOI 10.1002/hep.21103
   Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929
   Shalhub S, 2004, OBES SURG, V14, P54, DOI 10.1381/096089204772787293
   Shi Y, 2019, CELL CHEM BIOL, V26, P319, DOI 10.1016/j.chembiol.2018.11.012
   Sumida Y, 2018, J GASTROENTEROL, V53, P362, DOI 10.1007/s00535-017-1415-1
   Taitano AA, 2015, J GASTROINTEST SURG, V19, P429, DOI 10.1007/s11605-014-2678-y
   Verbeek J, 2015, GUT, V64, P673, DOI 10.1136/gutjnl-2014-306748
   Vilar-Gomez E, 2015, GASTROENTEROLOGY, V149, P367, DOI 10.1053/j.gastro.2015.04.005
   Zein CO, 2011, HEPATOLOGY, V54, P1610, DOI 10.1002/hep.24544
NR 35
TC 4
Z9 4
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1550-7289
EI 1878-7533
J9 SURG OBES RELAT DIS
JI Surg. Obes. Relat. Dis.
PD MAY
PY 2020
VL 16
IS 5
BP 699
EP 703
DI 10.1016/j.soard.2020.01.028
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA LF4FG
UT WOS:000527374300019
PM 32151552
DA 2025-06-11
ER

PT J
AU Ramli, NZ
   Chin, KY
   Zarkasi, KA
   Ahmad, F
AF Ramli, Nur Zuliani
   Chin, Kok-Yong
   Zarkasi, Khairul Anwar
   Ahmad, Fairus
TI A Review on the Protective Effects of Honey against Metabolic Syndrome
SO NUTRIENTS
LA English
DT Review
DE honey; diabetes mellitus; dyslipidemia; hypertension; obesity
ID OBESITY-RELATED HYPERTENSION; CARDIOVASCULAR RISK-FACTORS; SUGAR-FREE
   DIET; NATURAL HONEY; BLOOD-PRESSURE; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; OXIDATIVE STRESS; ADIPOSE-TISSUE; WEIGHT-GAIN
AB Metabolic syndrome (MetS) is a cluster of diseases comprising of obesity, diabetes mellitus, dyslipidemia, and hypertension. There are numerous pre-clinical as well as human studies reporting the protective effects of honey against MetS. Honey is a nutritional food low in glycemic index. Honey intake reduces blood sugar levels and prevents excessive weight gain. It also improves lipid metabolism by reducing total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and increasing high-density lipoprotein (HDL), which leads to decreased risk of atherogenesis. In addition, honey enhances insulin sensitivity that further stabilizes blood glucose levels and protects the pancreas from overstimulation brought on by insulin resistance. Furthermore, antioxidative properties of honey help in reducing oxidative stress, which is one of the central mechanisms in MetS. Lastly, honey protects the vasculature from endothelial dysfunction and remodelling. Therefore, there is a strong potential for honey supplementation to be integrated into the management of MetS, both as preventive as well as adjunct therapeutic agents.
C1 [Ramli, Nur Zuliani; Ahmad, Fairus] Univ Kebangsaan Malaysia, Dept Anat, UKM Med Ctr, Fac Med, Kuala Lumpur 56000, Malaysia.
   [Ramli, Nur Zuliani; Zarkasi, Khairul Anwar] Univ Malaysia Sabah, Dept Biomed Sci & Therapeut, Fac Med & Hlth Sci, Kota Kinabalu 88400, Sabah, Malaysia.
   [Chin, Kok-Yong] Univ Kebangsaan Malaysia, Dept Pharmacol, UKM Med Ctr, Fac Med, Kuala Lumpur 56000, Malaysia.
   [Zarkasi, Khairul Anwar] Univ Kebangsaan Malaysia, Dept Biochem, UKM Med Ctr, Fac Med, Kuala Lumpur 56000, Malaysia.
C3 Universiti Kebangsaan Malaysia; Universiti Malaysia Sabah; Universiti
   Kebangsaan Malaysia; Universiti Kebangsaan Malaysia
RP Ahmad, F (corresponding author), Univ Kebangsaan Malaysia, Dept Anat, UKM Med Ctr, Fac Med, Kuala Lumpur 56000, Malaysia.
EM nurzuliani@ums.edu.my; chinkokyong@ppukm.ukm.edu.my;
   khairul.anwar@ums.edu.my; fairusahmad@ukm.edu.my
RI Ramli, Nur Zuliani/AAB-3789-2021; Zarkasi, Khairul Anwar/HDN-0080-2022;
   Chin, Kok-Yong/B-6309-2015
OI Ahmad, Fairus/0000-0002-2452-6459; Chin, Kok-Yong/0000-0001-6628-1552;
   Ramli, Nur Zuliani/0000-0001-6700-3706; Zarkasi, Khairul
   Anwar/0000-0003-0766-6537
FU Universiti Kebangsaan Malaysia [FF-2017-446, GUP-2017-060]
FX This work was funded by grants FF-2017-446 and GUP-2017-060 from
   Universiti Kebangsaan Malaysia.
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Ahmed S, 2013, MALAYS J MED SCI, V20, P6
   Ajibola A, 2013, INDIAN J EXP BIOL, V51, P303
   Al-Waili N, 2003, EUR J MED RES, V8, P295
   Al-Waili N, 2013, J MED FOOD, V16, P1063, DOI 10.1089/jmf.2012.0285
   Al-Waili Noori S., 2003, Journal of Medicinal Food, V6, P359, DOI 10.1089/109662003772519921
   Al-Waili NS, 2004, J MED FOOD, V7, P100, DOI 10.1089/109662004322984789
   Alamshah A, 2017, INT J OBESITY, V41, P1693, DOI 10.1038/ijo.2017.164
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Aluko E. O., 2013, British Journal of Medicine and Medical Research, V3, P2214
   Aluko EO., 2014, FRONT SCI, V4, P8, DOI [10.5923/j.fs.20140401.02, DOI 10.5923/J.FS.20140401.02]
   Anand S, 2018, MOLECULES, V23, DOI 10.3390/molecules23010108
   Arabmoazzen S, 2015, IRAN J BASIC MED SCI, V18, P745
   Aschner P, 2017, DIABETES RES CLIN PR, V132, P169, DOI 10.1016/j.diabres.2017.09.002
   Aziz MSA, 2017, BIOMED PHARMACOTHER, V89, P135, DOI 10.1016/j.biopha.2017.02.026
   Bahrami M, 2009, INT J FOOD SCI NUTR, V60, P618, DOI 10.3109/09637480801990389
   Bilkisu M. M., 2011, RES PHARM BIOTECHNOL, V3, P118
   Bogdanov S, 2008, J AM COLL NUTR, V27, P677, DOI 10.1080/07315724.2008.10719745
   Bourgoin F, 2008, AM J PHYSIOL-HEART C, V295, pH1044, DOI 10.1152/ajpheart.00516.2008
   Buratti S, 2007, TALANTA, V71, P1387, DOI 10.1016/j.talanta.2006.07.006
   Busserolles J, 2002, J NUTR, V132, P3379, DOI 10.1093/jn/132.11.3379
   Chepulis L, 2008, J FOOD SCI, V73, pH1, DOI 10.1111/j.1750-3841.2007.00592.x
   Chepulis LM, 2007, J FOOD SCI, V72, pS224, DOI 10.1111/j.1750-3841.2007.00286.x
   Codex Alimentarius Commission, 2001, REV COD STAND HON CO
   Crane E., 2009, Encyclopedia of Insects, P459
   Dell'Omo G, 2004, ATHEROSCLEROSIS, V172, P383, DOI 10.1016/j.atherosclerosis.2003.11.013
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Després JP, 2006, ANN MED, V38, P52, DOI 10.1080/07853890500383895
   Engeli S, 2000, HYPERTENSION, V35, P1270, DOI 10.1161/01.HYP.35.6.1270
   Erejuwa OO, 2010, ANN ENDOCRINOL-PARIS, V71, P291, DOI 10.1016/j.ando.2010.03.003
   Erejuwa OO, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030095
   Erejuwa OO, 2012, OXID MED CELL LONGEV, V2012, DOI 10.1155/2012/374037
   Erejuwa OO, 2011, INT J MOL SCI, V12, P1888, DOI 10.3390/ijms12031888
   Feás X, 2010, INT J FOOD SCI TECH, V45, P1255, DOI 10.1111/j.1365-2621.2010.02268.x
   Galal RM, 2012, ARCH IRAN MED, V15, P674, DOI 0121511/AIM.006
   Ganeshpurkar Aditya, 2013, Ayu, V34, P109, DOI 10.4103/0974-8520.115446
   Ghasemi A, 2014, ACTA PHYSIOL HUNG, V101, P408, DOI 10.1556/APhysiol.101.2014.4.2
   Gomes T, 2011, MOLECULES, V16, P5374, DOI 10.3390/molecules16075374
   Gordan R, 2015, WORLD J CARDIOL, V7, P204, DOI 10.4330/wjc.v7.i4.204
   Grundy SM, 2006, NAT REV DRUG DISCOV, V5, P294, DOI 10.1038/nrd2005
   Gupta R., 2016, Res Rev J Med Health Sci, V5, P1
   Hemmati M., 2015, J. Pharm. Pharmacol, V3, P278, DOI [DOI 10.17265/2328-2150/2015.06.004, 10.17265/2328-2150/2015.06.004]
   Hsieh CC, 2016, J FOOD DRUG ANAL, V24, P754, DOI 10.1016/j.jfda.2016.03.005
   Iglesias A, 2012, MOLECULES, V17, P8561, DOI 10.3390/molecules17078561
   Jalal DI, 2010, J AM SOC NEPHROL, V21, P1543, DOI 10.1681/ASN.2009111111
   Jamnik J, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2016-013191
   Jansen SA, 2012, CARDIOVASC TOXICOL, V12, P208, DOI 10.1007/s12012-012-9162-2
   Jürgens H, 2005, OBES RES, V13, P1146, DOI 10.1038/oby.2005.136
   Karlsson C, 1998, J CLIN ENDOCR METAB, V83, P3925, DOI 10.1210/jc.83.11.3925
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kek SP, 2017, FOOD ANAL METHOD, V10, P19, DOI 10.1007/s12161-016-0544-0
   Khalil MI, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/286051
   Kolovou GD, 2005, POSTGRAD MED J, V81, P358, DOI 10.1136/pgmj.2004.025601
   Krishnasree V, 2017, INDIAN J TRADIT KNOW, V16, P134
   Landsberg L, 2001, J HYPERTENS, V19, P523, DOI 10.1097/00004872-200103001-00001
   Landsberg L, 2013, OBESITY, V21, P8, DOI 10.1002/oby.20181
   Li SS, 2009, JAMA-J AM MED ASSOC, V302, P179, DOI 10.1001/jama.2009.976
   Libby P, 2011, NATURE, V473, P317, DOI 10.1038/nature10146
   Maher RL, 2014, EXPERT OPIN DRUG SAF, V13, P57, DOI 10.1517/14740338.2013.827660
   Maiuolo J, 2016, INT J CARDIOL, V213, P8, DOI 10.1016/j.ijcard.2015.08.109
   Mamikutty N, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/263897
   Matsuzawa Y, 2011, J ATHEROSCLER THROMB, V18, P629, DOI 10.5551/jat.7922
   Mohamud WNW, 2011, DIABETES RES CLIN PR, V91, P239, DOI 10.1016/j.diabres.2010.11.025
   Münstedt K, 2009, J MED FOOD, V12, P624, DOI 10.1089/jmf.2008.0188
   Mushtaq R, 2011, PAK J ZOOL, V43, P161
   Negre-Salvayre A, 2010, FREE RADICAL RES, V44, P1125, DOI 10.3109/10715762.2010.498478
   Nemoseck TM, 2011, NUTR RES, V31, P55, DOI 10.1016/j.nutres.2010.11.002
   Nordestgaard BG, 2016, CIRC RES, V118, P547, DOI 10.1161/CIRCRESAHA.115.306249
   Öztasan N, 2005, TURK J VET ANIM SCI, V29, P1093
   Pires J, 2009, J SCI FOOD AGR, V89, P1862, DOI 10.1002/jsfa.3663
   Potenza MV, 2009, NUTR CLIN PRACT, V24, P560, DOI 10.1177/0884533609342436
   Rahmouni K, 2010, CURR HYPERTENS REV, V6, P104, DOI 10.2174/157340210791170994
   RAIVIO KO, 1975, METABOLISM, V24, P861, DOI 10.1016/0026-0495(75)90133-X
   Ranasinghe P, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4041-1
   Rao PV, 2016, REV BRAS FARMACOGN, V26, P657, DOI 10.1016/j.bjp.2016.01.012
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Rojo AI, 2008, MOL CELL NEUROSCI, V39, P125, DOI 10.1016/j.mcn.2008.06.007
   Romero-Silva S, 2011, LETT DRUG DES DISCOV, V8, P69, DOI 10.2174/157018011793663912
   Saba ZH, 2013, MED HEALTH-KUALA LUM, V8, P3
   Samson SL, 2014, ENDOCRIN METAB CLIN, V43, P1, DOI 10.1016/j.ecl.2013.09.009
   Sarwar N, 2010, LANCET, V375, P2215, DOI 10.1016/s0140-6736(10)60484-9
   Satarupta R., 2014, Asian Journal of Chemical and Pharmaceutical Research, V2, P96
   Schulz E, 2011, HYPERTENS RES, V34, P665, DOI 10.1038/hr.2011.39
   Shapiro MD, 2016, CIRC RES, V118, P732, DOI 10.1161/CIRCRESAHA.115.306471
   Shin JA, 2013, J DIABETES INVEST, V4, P334, DOI 10.1111/jdi.12075
   Shulman GI, 2014, NEW ENGL J MED, V371, P1131, DOI 10.1056/NEJMra1011035
   Simonds SE, 2014, CELL, V159, P1404, DOI 10.1016/j.cell.2014.10.058
   Solayman M, 2016, COMPR REV FOOD SCI F, V15, P219, DOI 10.1111/1541-4337.12182
   Song XY, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0049545
   Sonia T.A., 2014, Oral Delivery of Insulin, P1
   Srivatsan R, 2009, ARCH IRAN MED, V12, P121
   Stanhope KL, 2009, J CLIN INVEST, V119, P1322, DOI 10.1172/JCI37385
   Stincone A, 2015, BIOL REV, V90, P927, DOI 10.1111/brv.12140
   Sun SZ, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-89
   Suzuki K, 2000, ELECTROPHORESIS, V21, P285, DOI 10.1002/(SICI)1522-2683(20000101)21:2<285::AID-ELPS285>3.0.CO;2-5
   Vallianou N., 2014, General Medicine Journal, V2, P1
   Wong SK, 2016, NUTRIENTS, V8, DOI 10.3390/nu8060347
   Yadav A, 2013, CLIN CHIM ACTA, V417, P80, DOI 10.1016/j.cca.2012.12.007
   Yaghoobi N, 2008, THESCIENTIFICWORLDJO, V8, P463, DOI 10.1100/tsw.2008.64
   Yong Y.K., 2016, P 26 SCI M INT SOC H, pe328
   Zhang X, 2015, ANTIOXID REDOX SIGN, V22, P848, DOI 10.1089/ars.2014.5868
   Zhang Y, 2008, CELL MOL LIFE SCI, V65, P3699, DOI 10.1007/s00018-008-8295-8
NR 105
TC 51
Z9 55
U1 0
U2 30
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2018
VL 10
IS 8
AR 1009
DI 10.3390/nu10081009
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GU9PD
UT WOS:000445680200057
PM 30072671
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Marycz, K
   Weiss, C
   Smieszek, A
   Kornicka, K
AF Marycz, Krzysztof
   Weiss, Christine
   Smieszek, Agnieszka
   Kornicka, Katarzyna
TI Evaluation of Oxidative Stress and Mitophagy during Adipogenic
   Differentiation of Adipose-Derived Stem Cells Isolated from Equine
   Metabolic Syndrome (EMS) Horses
SO STEM CELLS INTERNATIONAL
LA English
DT Article
ID INSULIN-RESISTANCE; TISSUE; AUTOPHAGY; EXPRESSION; RECEPTOR; GENES;
   ALPHA; LIVER; IL-6
AB Mesenchymal stem cells (MSCs) are frequently used in both human and veterinary medicine because their unique properties, such as modulating the immune response and differentiating into multiple lineages, make them a valuable tool in cell-based therapies. However, many studies have indicated the age-, lifestyle-, and disease-related deterioration of MSC regenerative characteristics. However, it still needs to be elucidated how the patient's health status affects the effectiveness of MSC differentiation. In the present study, we isolated mesenchymal stem cells from adipose tissue (adipose-derived mesenchymal stem cells (ASCs)) from horses diagnosed with equine metabolic syndrome (EMS), a common metabolic disorder characterized by pathological obesity and insulin resistance. We investigated the metabolic status of isolated cells during adipogenic differentiation using multiple research methods, such as flow cytometry, PCR, immunofluorescence, or transmission and confocal microscopy. The results indicated the impaired differentiation potential of ASCEMS. Excessive ROS accumulation and ER stress are most likely the major factors limiting the multipotency of these cells. However, we observed autophagic flux during differentiation as a protective mechanism that allows cells to maintain homeostasis and remove dysfunctional mitochondria.
C1 [Marycz, Krzysztof; Smieszek, Agnieszka; Kornicka, Katarzyna] Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt, Norwida 25, PL-50375 Wroclaw, Poland.
   [Marycz, Krzysztof] Wroclaw Res Ctr EIT, Stablowicka 147, PL-54066 Wroclaw, Poland.
   [Weiss, Christine] PferdePraxis Dr Med Vet Daniel Weiss, Postmatte 14, CH-8807 Freienbach, Switzerland.
C3 Wroclaw University of Environmental & Life Sciences
RP Marycz, K (corresponding author), Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt, Norwida 25, PL-50375 Wroclaw, Poland.
EM krzysztof.marycz@upwr.edu.pl
RI Smieszek, Agnieszka/A-4887-2017
OI Smieszek, Agnieszka/0000-0002-7314-9821
FU National Science Centre, Poland [2016/21/B/NZ7/01111]; Wroclaw Centre of
   Biotechnology programme from the Leading National Research Centre (KNOW)
FX This research was supported by the National Science Centre, Poland
   through Grant no. 2016/21/B/NZ7/01111 "Modulation mitochondrial
   metabolism and dynamics and targeting DNA methylation of adipose-derived
   mesenchymal stromal stem cell (ASC) using resveratrol and 5-azacytydin
   as a therapeutic strategy in the course of equine metabolic syndrome
   (EMS)." This publication was supported by the Wroclaw Centre of
   Biotechnology programme from the Leading National Research Centre (KNOW)
   for years 2014-2018.
CR Abdi R, 2008, DIABETES, V57, P1759, DOI 10.2337/db08-0180
   Barone AAL, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/383685
   Basinska K, 2015, J VET SCI, V16, P113, DOI [10.4142/jvs.2015.16.1.113, 10.4142/jvs.2015.16.1.107]
   CAPLAN AI, 1991, J ORTHOP RES, V9, P641, DOI 10.1002/jor.1100090504
   Chamberlain G, 2007, STEM CELLS, V25, P2739, DOI 10.1634/stemcells.2007-0197
   CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1006/abio.1987.9999
   Collino F, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011803
   Cuervo A. M., 2011, TRENDS GENET, V24, P604
   Cuervo AM, 2005, AUTOPHAGY, V1, P131, DOI 10.4161/auto.1.3.2017
   Meirelles LDS, 2006, J CELL SCI, V119, P2204, DOI 10.1242/jcs.02932
   Dubois SG, 2006, OBESITY, V14, P1543, DOI 10.1038/oby.2006.178
   Fernández-Trasancos A, 2014, J CELL PHYSIOL, V229, P1722, DOI 10.1002/jcp.24619
   Forni MF, 2016, STEM CELLS, V34, P743, DOI 10.1002/stem.2248
   Frank N, 2009, J EQUINE VET SCI, V29, P259, DOI 10.1016/j.jevs.2009.04.183
   Grzesiak Jakub, 2011, Int J Stem Cells, V4, P99
   Gustafson B, 2015, TRENDS ENDOCRIN MET, V26, P193, DOI 10.1016/j.tem.2015.01.006
   Hashemian SJ, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/675103
   Huh JE, 2013, BBA-MOL CELL RES, V1833, P2608, DOI 10.1016/j.bbamcr.2013.06.025
   Jaganjac M, 2017, REDOX BIOL, V12, P483, DOI 10.1016/j.redox.2017.03.012
   Jansen HJ, 2012, ENDOCRINOLOGY, V153, P5866, DOI 10.1210/en.2012-1625
   Jumabay M, 2015, J CELL PHYSIOL, V230, P2821, DOI 10.1002/jcp.25012
   Kang HS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0058417
   Kawasaki N, 2012, SCI REP-UK, V2, DOI 10.1038/srep00799
   Kovsan J, 2011, J CLIN ENDOCR METAB, V96, pE268, DOI 10.1210/jc.2010-1681
   Liu LF, 2015, DIABETOLOGIA, V58, P1579, DOI 10.1007/s00125-015-3603-y
   Mandal S, 2011, STEM CELLS, V29, P486, DOI 10.1002/stem.590
   Maredziak M, 2015, IN VITRO CELL DEV-AN, V51, P230, DOI 10.1007/s11626-014-9828-0
   Marycz K, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19010165
   Marycz K, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/3718468
   Marycz K, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/4710326
   Marycz K, 2016, J CELL MOL MED, V20, P2384, DOI 10.1111/jcmm.12932
   Marycz K, 2016, STEM CELLS INT, V2016, DOI 10.1155/2016/5756901
   Memon RA, 2000, ENDOCRINOLOGY, V141, P4021, DOI 10.1210/en.141.11.4021
   Minamino T, 2009, NAT MED, V15, P1082, DOI 10.1038/nm.2014
   NAWROCKA D, 2017, OXID MED CELL LONGEV, V2017, DOI DOI 10.1155/2017/3027109
   Nawrocka D, 2017, MAR DRUGS, V15, DOI 10.3390/md15080237
   Pérez-Campo FM, 2015, CURR GENOMICS, V16, P368, DOI 10.2174/1389202916666150817202559
   Starosta R, 2013, POLYHEDRON, V50, P481, DOI 10.1016/j.poly.2012.11.033
   Suszynska M, 2014, J OVARIAN RES, V7, DOI 10.1186/1757-2215-7-66
   Xu M, 2015, ELIFE, V4, DOI 10.7554/eLife.12997
   Yang J, 2012, OBESITY, V20, P932, DOI 10.1038/oby.2011.371
   Yasuda-Yamahara M, 2015, BIOCHEM BIOPH RES CO, V465, P249, DOI 10.1016/j.bbrc.2015.08.010
   Zhang SJ, 2014, STEM CELLS, V32, P1616, DOI 10.1002/stem.1632
NR 43
TC 38
Z9 38
U1 0
U2 4
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-966X
EI 1687-9678
J9 STEM CELLS INT
JI Stem Cells Int.
PY 2018
VL 2018
AR 5340756
DI 10.1155/2018/5340756
PG 18
WC Cell & Tissue Engineering
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA GK0XY
UT WOS:000435837000001
PM 29977307
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Manojlovic-Stojanoski, M
   Nestorovic, N
   Petkovic, B
   Balind, SR
   Ristic, N
   Trifunovic, S
   Ajdzanovic, V
   Filipovic, B
   Sosic-Jurjevic, B
   Milosevic, V
AF Manojlovic-Stojanoski, Milica
   Nestorovic, Natasa
   Petkovic, Branka
   Balind, Snezana Raus
   Ristic, Natasa
   Trifunovic, Svetlana
   Ajdzanovic, Vladimir
   Filipovic, Branko
   Sosic-Jurjevic, Branka
   Milosevic, Verica
TI The effects of prenatal dexamethasone exposure and fructose challenge on
   pituitary-adrenocortical activity and anxiety-like behavior in female
   offspring
SO TISSUE & CELL
LA English
DT Article
DE Adrenal gland; Stereology; Programming; Dexamethasone; Fructose
ID ENDOTHELIAL GROWTH-FACTOR; GLUCOCORTICOID TREATMENT; METABOLIC SYNDROME;
   DIET; EXPRESSION; DECREASES; SECRETION; TISSUE; MICE; RAT
AB Prenatal glucocorticoid overexposure could largely influence pituitary-adrenal activity and anxiety-like behavior in offspring. Our aim was to study the possible potentiating effect of moderate dose of fructose - common ingredient of today's diet - on prenatal glucocorticoid treatment-induced hypothalamo-pituitary-adrenal (HPA) axis changes. Pregnant female rats were treated with multiple dexamethasone (Dx) doses (3 x 0.5 mg/kg/b.m. Dx; 16th-18th gestational day). Half of female offspring from control and Dx treated dams were supplemented with 10% fructose solution, from weaning fill adulthood. Immunohistochemistry, unbiased stereological evaluation and hormonal analysis are used to provide the morpho-functional state of pituitary and adrenal gland. Anxiety-like behavior was assessed using the light/dark box WA and the elevated plus maze test. Prenatally Dx exposed females, with or without fructose consumption, had markedly reduced adrenocortical volume (p < 0.05) comparing to controls. Increased basal plasma ACTH level in these females (p < 0.05) maintained corticosterone concentration at control level produced by smaller adrenal glands. In parallel, anxiety-like behavior was shown by both tests used. In conclusion, prenatal Dx exposure cause negative psychophysiological outcome reflected in increased HPA axis activity and anxiety behavior in female offspring, while moderately increased fructose consumption failed to evoke any alteration or to potentiate effects of prenatal Dx exposure.
C1 [Manojlovic-Stojanoski, Milica; Nestorovic, Natasa; Petkovic, Branka; Balind, Snezana Raus; Ristic, Natasa; Trifunovic, Svetlana; Ajdzanovic, Vladimir; Filipovic, Branko; Sosic-Jurjevic, Branka; Milosevic, Verica] Univ Belgrade, Inst Biol Res Sinisa Stankovic, Natl Inst Republ Serbia, 142 Despota Stefana Blvd, Belgrade 11060, Serbia.
C3 University of Belgrade
RP Manojlovic-Stojanoski, M (corresponding author), Univ Belgrade, Inst Biol Res Sinisa Stankovic, Natl Inst Republ Serbia, 142 Despota Stefana Blvd, Belgrade 11060, Serbia.
EM manojlo@ibiss.bg.ac.rs
RI Dinic, Svetlana/C-8348-2017; Ristić, Nataša/O-8974-2016; Nestorovic,
   Natasa/C-6412-2016; Manojlovic-Stojanoski, Milica/JNS-5001-2023;
   Sosic-Jurjevic, Branka/AHD-4810-2022; Petkovic, Branka/GNH-5614-2022
OI Raus Balind, Snezana/0000-0003-1657-4677; Nestorovic,
   Natasa/0000-0001-6218-988X; Ajdzanovic, Vladimir/0000-0002-6540-9603; ,
   Svetlana/0000-0002-9141-5732; Filipovic, Branko/0000-0001-5352-763X;
   Manojlovic-Stojanoski, Milica/0000-0003-0511-8799; Sosic-Jurjevic,
   Branka/0000-0002-5496-0619; Petkovic, Branka/0000-0001-7817-4092
FU Ministry of Education and Technological Development [173009]
FX This work was supported by the Ministry of Education and Technological
   Development, Grant number 173009. The Ministry's involvement was only of
   financial nature.
CR Agnew EJ, 2018, J MOL ENDOCRINOL, V61, pR61, DOI 10.1530/JME-18-0077
   Ajdzanovic V, 2015, ACTA HISTOCHEM, V117, P528, DOI 10.1016/j.acthis.2015.04.002
   Alexander N, 2012, J CLIN ENDOCR METAB, V97, P3538, DOI 10.1210/jc.2012-1970
   Barker DJP, 2002, TRENDS ENDOCRIN MET, V13, P364, DOI 10.1016/S1043-2760(02)00689-6
   Basciano Heather, 2005, Nutr Metab (Lond), V2, P5, DOI 10.1186/1743-7075-2-5
   Bukhari SHF, 2018, LIFE SCI, V197, P114, DOI 10.1016/j.lfs.2018.02.010
   Carbone DL, 2012, ENDOCRINOLOGY, V153, P295, DOI 10.1210/en.2011-1601
   Carson R, 2016, STEROIDS, V114, P25, DOI 10.1016/j.steroids.2016.05.012
   Cottrell EC, 2009, FRONT BEHAV NEUROSCI, V3, DOI 10.3389/neuro.08.019.2009
   Culpepper L, 2009, J CLIN PSYCHIAT, V70, P20, DOI 10.4088/JCP.s.7002.04
   Dorph-Petersen KA, 2001, J MICROSC-OXFORD, V204, P232, DOI 10.1046/j.1365-2818.2001.00958.x
   Engeland WC, 2005, AM J PHYSIOL-ENDOC M, V288, pE298, DOI 10.1152/ajpendo.00307.2004
   Ferrara N, 1999, KIDNEY INT, V56, P794, DOI 10.1046/j.1523-1755.1999.00610.x
   Flandreau E., 2012, Chronic overexpression of corticotropin-releasing factor from the central amygdala produces HPA axis hyperactivity and behavioral anxiety associated with gene-expression changes in the hippocampus and paraventricular nucleus of the hypothalamus
   Fuller PJ, 2009, HORMONES, BRAIN AND BEHAVIOR, VOLS 1-5, 2ND EDITION, P1421
   Gancheva S, 2017, INT J EXP PATHOL, V98, P296, DOI 10.1111/iep.12254
   Garcia-Rizo C, 2015, ACTA PSYCHIAT SCAND, V131, P18, DOI 10.1111/acps.12309
   Goel N, 2014, COMPR PHYSIOL, V4, P1121, DOI 10.1002/cphy.c130054
   Harrell CS, 2015, PSYCHONEUROENDOCRINO, V62, P252, DOI 10.1016/j.psyneuen.2015.08.025
   Harris A, 2011, HORM BEHAV, V59, P279, DOI 10.1016/j.yhbeh.2010.06.007
   Hiroi R, 2016, NEUROSCIENCE, V320, P43, DOI 10.1016/j.neuroscience.2016.01.055
   Holmes MC, 2006, J NEUROSCI, V26, P3840, DOI 10.1523/JNEUROSCI.4464-05.2006
   Huang LT, 2011, PEDIATR RES, V69, p19R, DOI 10.1203/PDR.0b013e318212c29b
   John CD, 2006, J NEUROENDOCRINOL, V18, P949, DOI 10.1111/j.1365-2826.2006.01493.x
   Kapoor A, 2008, BRAIN RES REV, V57, P586, DOI 10.1016/j.brainresrev.2007.06.013
   Kovacevic S, 2014, EUR J NUTR, V53, P1409, DOI 10.1007/s00394-013-0644-1
   LIGGINS GC, 1972, PEDIATRICS, V50, P515
   Martin EI, 2009, PSYCHIAT CLIN N AM, V32, P549, DOI 10.1016/j.psc.2009.05.004
   Nagano M, 2008, NEUROSCI RES, V60, P364, DOI 10.1016/j.neures.2007.12.005
   Noorlander CW, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0085671
   Nousen EK, 2013, NEUROENDOCRINOLOGY, V98, P254, DOI 10.1159/000355632
   Rabadán-Diehl C, 2013, J DEV ORIG HLTH DIS, V4, P3, DOI 10.1017/S2040174412000487
   Raglan GB, 2017, ENDOCR CONNECT, V6, pR1, DOI 10.1530/EC-16-0100
   Roberts D, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004454.pub3
   Ruggiero C, 2016, FRONT ENDOCRINOL, V7, DOI 10.3389/fendo.2016.00024
   Shifren JL, 1998, J CLIN ENDOCR METAB, V83, P1342, DOI 10.1210/jc.83.4.1342
   Shoener JA, 2006, AM J PHYSIOL-REG I, V290, pR1366, DOI 10.1152/ajpregu.00757.2004
   TAKAHASHI LK, 1992, BRAIN RES, V574, P131, DOI 10.1016/0006-8993(92)90809-N
   Tappy L, 2010, PHYSIOL REV, V90, P23, DOI 10.1152/physrev.00019.2009
   Tonstad S., 2007, Metabolic Syndrome and Related Disorders, V5, P174, DOI 10.1089/met.2006.0037
   Vinson GP, 2016, FRONT NEUROSCI-SWITZ, V10, DOI 10.3389/fnins.2016.00238
NR 41
TC 3
Z9 3
U1 0
U2 1
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0040-8166
J9 TISSUE CELL
JI Tissue Cell
PD FEB
PY 2020
VL 62
AR 101309
DI 10.1016/j.tice.2019.101309
PG 10
WC Anatomy & Morphology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anatomy & Morphology; Cell Biology
GA KE9TC
UT WOS:000508892200006
PM 32433017
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Rodríguez-Fierros, FL
   Guarner-Lans, V
   Soto, ME
   Manzano-Pech, L
   Díaz-Díaz, E
   Soria-Castro, E
   Rubio-Ruiz, ME
   Jiménez-Trejo, F
   Pérez-Torres, I
AF Rodriguez-Fierros, Felix Leao
   Guarner-Lans, Veronica
   Soto, Maria Elena
   Manzano-Pech, Linaloe
   Diaz-Diaz, Eulises
   Soria-Castro, Elizabeth
   Rubio-Ruiz, Maria Esther
   Jimenez-Trejo, Francisco
   Perez-Torres, Israel
TI Modulation of Renal Function in a Metabolic Syndrome Rat Model by
   Antioxidants in Hibiscus sabdariffa L.
SO MOLECULES
LA English
DT Article
DE metabolic syndrome; Hibiscus sabdariffa L; oxidative stress; kidney;
   renal function
AB Metabolic syndrome (MS) is the association of three or more pathologies among which obesity, hypertension, insulin resistance, dyslipidemia, and diabetes are included. It causes oxidative stress (OS) and renal dysfunction. Hibiscus sabdariffa L. (HSL) is a source of natural antioxidants that may control the renal damage caused by the MS. The objective of this work was to evaluate the effect of a 2% HSL infusion on renal function in a MS rat model induced by the administration of 30% sucrose in drinking water. 24 male Wistar rats were divided into 3 groups: Control rats, MS rats and MS + HSL rats. MS rats had increased body weight, systolic blood pressure, triglycerides, insulin, HOMA index, and leptin (p <= 0.04). Renal function was impaired by an increase in perfusion pressure in the isolated and perfused kidney, albuminuria (p <= 0.03), and by a decrease in clearance of creatinine (p <= 0.04). The activity of some antioxidant enzymes including the superoxide dismutase isoforms, peroxidases, glutathione peroxidase, glutathione-S-transferase was decreased (p <= 0.05). Lipoperoxidation and carbonylation were increased (p <= 0.001). The nitrates/nitrites ratio, total antioxidant capacity, glutathione levels and vitamin C were decreased (p <= 0.03). The treatment with 2% HSL reversed these alterations. The results suggest that the treatment with 2% HSL infusion protects renal function through its natural antioxidants which favor an improved renal vascular response. The infusion contributes to the increase in the glomerular filtration rate, by promoting an increase in the enzymatic and non-enzymatic antioxidant systems leading to a decrease in OS and reestablishing the normal renal function.
C1 [Rodriguez-Fierros, Felix Leao; Manzano-Pech, Linaloe; Soria-Castro, Elizabeth; Perez-Torres, Israel] Inst Nacl Cardiol Ignacio Chavez, Dept Cardiovasc Biomed, Juan Badiano 1,Secc XVI, Mexico City 14080, DF, Mexico.
   [Guarner-Lans, Veronica; Rubio-Ruiz, Maria Esther] Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Juan Badiano 1,Secc XVI, Mexico City 14080, DF, Mexico.
   [Soto, Maria Elena] Inst Nacl Cardiol Ignacio Chavez, Dept Immunol, Juan Badiano 1,Secc XVI, Mexico City 14080, DF, Mexico.
   [Diaz-Diaz, Eulises] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Vasco de Quiroga 15,Secc XVI, Mexico City 14000, DF, Mexico.
   [Jimenez-Trejo, Francisco] Inst Nacl Pediat, Dept Reprod Biol, Insurgentes Sur 3700-C, Mexico City 04530, DF, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico; National Institute of Cardiology - Mexico;
   Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico
RP Pérez-Torres, I (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Cardiovasc Biomed, Juan Badiano 1,Secc XVI, Mexico City 14080, DF, Mexico.
EM felixleao@hotmail.com; gualanv@yahoo.com; mesoto50@hotmail.com;
   loe_mana@hotmail.com; eulisesd@yahoo.com; elizabethsoria824@gmail.com;
   esther_rubio_ruiz@yahoo.com; trejofj@hotmail.com;
   israel.perez@cardiologia.org.mx
RI Pérez Torres, Israel/AAE-2579-2022; Guarner-Lans, Verónica/AFW-3723-2022
OI Soto, Maria Elena/0000-0003-1332-2888; Perez-Torres,
   Israel/0000-0001-6510-2954; Guarner-Lans, Veronica/0000-0002-2655-7590;
   Rubio-Ruiz, Maria Esther/0000-0002-8844-2078
FU Postgraduate Section in the Program of Maestria y Doctorado en Ciencias
   de la Produccion y de la Salud Animal of the UNAM
FX We thank the Postgraduate Section in the Program of Maestria y Doctorado
   en Ciencias de la Produccion y de la Salud Animal of the UNAM for a
   scholarship to Felix Leao Rodriguez-Fierros. We thank Benito Chavez
   Renteria for histology technical support.
CR Adler S, 2004, AM J PHYSIOL-RENAL, V287, pF907, DOI 10.1152/ajprenal.00060.2004
   Aisa-Alvarez A, 2020, MEDICINA-LITHUANIA, V56, DOI 10.3390/medicina56110619
   Ali BH, 2017, J PHARM PHARMACOL, V69, P1219, DOI 10.1111/jphp.12748
   Azadmanesh J, 2018, ANTIOXIDANTS-BASEL, V7, DOI 10.3390/antiox7020025
   Bajic VP, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/5028181
   BENGERSHOM E, 1975, CLIN CHEM, V21, P1795
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Bretón-Romero R, 2014, REDOX BIOL, V2, P529, DOI 10.1016/j.redox.2014.02.005
   Chou ST, 2016, J ETHNOPHARMACOL, V194, P617, DOI 10.1016/j.jep.2016.10.059
   Correia AG, 2000, HYPERTENSION, V35, P965, DOI 10.1161/01.HYP.35.4.965
   Cseko C, 2004, J APPL PHYSIOL, V97, P1130, DOI 10.1152/japplphysiol.00106.2004
   Curtis JM, 2010, DIABETES, V59, P1132, DOI 10.2337/db09-1105
   Diez-Echave P, 2020, FOOD RES INT, V127, DOI 10.1016/j.foodres.2019.108722
   Soto ME, 2016, MEDIAT INFLAMM, V2016, DOI 10.1155/2016/8625203
   Erdei N, 2007, AM J PHYSIOL-HEART C, V292, pH649, DOI 10.1152/ajpheart.00596.2006
   Rubio-Ruiz ME, 2019, MOLECULES, V24, DOI 10.3390/molecules24071297
   Ghadge AA, 2019, CYTOKINE, V121, DOI 10.1016/j.cyto.2019.154735
   Goyal MM, 2010, PROTEIN CELL, V1, P888, DOI 10.1007/s13238-010-0113-z
   Hashimoto S, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0242332
   Hatoum OA, 2005, AM J PHYSIOL-HEART C, V288, pH48, DOI 10.1152/ajpheart.00663.2004
   Ighodaro OM, 2018, ALEX J MED, V54, P287, DOI 10.1016/j.ajme.2017.09.001
   Imig JD, 2000, GEN PHARMACOL-VASC S, V34, P409, DOI 10.1016/S0306-3623(01)00078-7
   Jaffe M., 1886, Z PHYSL CHEM, V10, P391, DOI DOI 10.1515/BCHM1.1886.10.5.391
   JAGOTA SK, 1982, ANAL BIOCHEM, V127, P178, DOI 10.1016/0003-2697(82)90162-2
   Jia Z, 1999, FOOD CHEM, V64, P555, DOI 10.1016/S0308-8146(98)00102-2
   Joven J, 2014, MOL NUTR FOOD RES, V58, P1374, DOI 10.1002/mnfr.201300774
   Jung O, 2003, CIRC RES, V93, P622, DOI 10.1161/01.RES.0000092140.81594.A8
   Kanner J, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9090797
   Krata N, 2018, ARCH IMMUNOL THER EX, V66, P211, DOI 10.1007/s00005-017-0496-0
   Lee J, 2005, J AOAC INT, V88, P1269
   Lee WC, 2009, J AGR FOOD CHEM, V57, P2206, DOI 10.1021/jf802993s
   Lim YC, 2017, CARDIOVASC TOXICOL, V17, P251, DOI 10.1007/s12012-016-9379-6
   Lin CY, 2009, J AGR FOOD CHEM, V57, P6661, DOI 10.1021/jf9015202
   Liu YW, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/5384909
   Locatelli F, 2006, J AM SOC NEPHROL, V17, pS81, DOI 10.1681/ASN.2005121332
   Makino A, 2003, HYPERTENSION, V42, P25, DOI 10.1161/01.HYP.0000074903.96928.91
   Zúñiga-Muñoz AM, 2017, VASA, V46, P177, DOI 10.1024/0301-1526/a000609
   Melchert A., 2016, ASIAN J ANIM VET ADV, V11, P693, DOI [10.3923/ajava.2016.693.700, DOI 10.3923/AJAVA.2016.693.700]
   Mirochnitchenko O, 1999, J BIOL CHEM, V274, P10349, DOI 10.1074/jbc.274.15.10349
   Nashar K, 2014, DIABET METAB SYND OB, V7, P421, DOI 10.2147/DMSO.S45183
   Nwachukwu DC, 2017, J PHYSIOL SCI, V67, P227, DOI 10.1007/s12576-016-0458-z
   Ojulari OV, 2019, MOLECULES, V24, DOI 10.3390/molecules24010210
   Ozbek E, 2012, INT J NEPHROL, V2012, DOI 10.1155/2012/465897
   Park SW, 2015, PFLUG ARCH EUR J PHY, V467, P285, DOI 10.1007/s00424-014-1513-3
   Pérez-Torres I, 2011, CURR TOP MED CHEM, V11, P1694
   Pérez-Torres I, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22041786
   Pérez-Torres I, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/1724194
   Pérez-Torres I, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18102098
   Pérez-Torres I, 2014, CLIN EXP HYPERTENS, V36, P123, DOI 10.3109/10641963.2013.789046
   Perez-Torres Israel, 2013, Cardiovascular & Hematological Agents in Medicinal Chemistry, V11, P25
   Pérez-Torres I, 2010, METABOLISM, V59, P414, DOI 10.1016/j.metabol.2009.08.014
   Pérez-Torres I, 2009, FREE RADICAL RES, V43, P761, DOI 10.1080/10715760903045296
   Prakash PA, 2009, SENSORS-BASEL, V9, P1821, DOI 10.3390/s90301821
   Rafikova O, 2008, METABOLISM, V57, P1434, DOI 10.1016/j.metabol.2008.05.014
   Raza H, 2011, FEBS J, V278, P4243, DOI 10.1111/j.1742-4658.2011.08358.x
   Riaz G, 2018, BIOMED PHARMACOTHER, V102, P575, DOI 10.1016/j.biopha.2018.03.023
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Rybka J, 2011, CARDIOVASC TOXICOL, V11, P1, DOI 10.1007/s12012-010-9096-5
   Samsam-Shariat SZ, 2014, ARYA ATHEROSCLER, V10, P218
   Rie S, 2007, BIOCHEM PHARMACOL, V74, P1619, DOI 10.1016/j.bcp.2007.08.008
   Sharma M, 2016, DIABETES METAB SYND, V10, P194, DOI 10.1016/j.dsx.2016.06.006
   Sies H, 2017, REDOX BIOL, V11, P613, DOI 10.1016/j.redox.2016.12.035
   Vávrová L, 2013, OBESITY FACTS, V6, P39, DOI 10.1159/000348569
   Wang S, 2014, J NUTR BIOCHEM, V25, P1, DOI 10.1016/j.jnutbio.2013.09.001
   Whitin JC, 2002, AM J PHYSIOL-RENAL, V283, pF20, DOI 10.1152/ajprenal.00014.2001
   Yang YS, 2013, J AGR FOOD CHEM, V61, P7545, DOI 10.1021/jf4020735
   Zuniga-Munoz A.M., 2013, ENDOC AGEN MED CHEM, V13, P1
   Zuo L, 2015, ACTA PHYSIOL, V214, P329, DOI 10.1111/apha.12515
NR 68
TC 16
Z9 16
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD APR
PY 2021
VL 26
IS 7
AR 2074
DI 10.3390/molecules26072074
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA RL1IA
UT WOS:000638734500001
PM 33916540
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lucena, S
   Coelho, AV
   Anjo, SI
   Manadas, B
   Mrljak, V
   Silva, FCE
   Lamy, E
   Tvarijonaviciute, A
AF Lucena, Sonia
   Coelho, Ana Varela
   Anjo, Sandra I.
   Manadas, Bruno
   Mrljak, Vladimir
   Capela e Silva, Fernando
   Lamy, Elsa
   Tvarijonaviciute, Asta
TI Comparative proteomic analysis of saliva from dogs with and without
   obesity-related metabolic dysfuntion
SO JOURNAL OF PROTEOMICS
LA English
DT Article
DE Dog; Saliva; Proteome; Obesity; Metabolic syndrome
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; SERUM; CYTOKINES; PROFILE
AB Dogs develop only some of the components of the human metabolic syndrome (MetS). Thus, in order to study possible MetS-related alterations in dogs, human MetS criteria were adapted to define canine MetS or so-called obesity-related metabolic dysfunction (ORMD). The main objective of this study was to identify changes in the salivary proteome of obese dogs with ORMD in comparison with obese dogs without ORMD which may constitute potential salivary biomarkers for assessing ORMD. In a first phase, 12 adult obese dogs with ORMD (N = 6) and without ORMD (N = 6) were included in the study. Subsequently, and with the aim of validating and strengthening the results, additional 12 obese dogs (6 with and 6 without ORMD) were tested in an independent experiment following the same protocol. Saliva samples were subjected to a quantitative proteomics analysis and the levels of nine salivary proteins were found to be significantly different between groups, among them those which had greatest fold-change were proteins involved in glycolysis and oxidative stress. In conclusion, despite metabolic syndrome to include different combinations of diseases, the observation of differences in salivary proteome suggests a potential of this fluid to understand the pathophysiology of the disease.
   Significance: This is the first study evaluating proteomes of saliva in dogs, as a non invasive sample, in order to increase knowledge about the metabolic/physiopathological changes related to obesity-related metabolic dysfunction (ORMD) together with the identification of potential biomarkers for its diagnosis. As approximately 20% of dogs with naturally occurring obesity were described to suffer ORMD associated with insulin resistance and hypoadiponectinemia, the fact that indicate possible links between ORMD and associated diseases.
C1 [Lucena, Sonia; Capela e Silva, Fernando; Lamy, Elsa] Univ Evora, Inst Agr & Environm Environm Sci ICAAM, Evora, Portugal.
   [Lucena, Sonia] Univ Evora, Sch Sci & Technol, Dept Vet Med, Evora, Portugal.
   [Coelho, Ana Varela] Univ Nova Lisboa, Inst Chem & Biol Technol ITQB, Lisbon, Portugal.
   [Anjo, Sandra I.; Manadas, Bruno] Univ Coimbra, CNC Ctr Neurosci & Cell Biol, Coimbra, Portugal.
   [Anjo, Sandra I.] Univ Coimbra, Fac Med, Coimbra, Portugal.
   [Mrljak, Vladimir] Univ Zagreb, Fac Vet Med, Clin Internal Dieaases, Heinzelova 55, Zagreb 10000, Croatia.
   [Capela e Silva, Fernando] Univ Evora, Sch Sci & Technol, Dept Biol, Evora, Portugal.
   [Tvarijonaviciute, Asta] Univ Murcia, Interlab UMU, Reg Campus Int Excellence, Campus Mare Nostrum, Ed 16,4a Pl,Campus Espinardo, E-30100 Murcia, Spain.
C3 University of Evora; University of Evora; Universidade Nova de Lisboa;
   Universidade de Coimbra; Universidade de Coimbra; University of Zagreb;
   University of Evora; University of Murcia
RP Tvarijonaviciute, A (corresponding author), Univ Murcia, Interlab UMU, Reg Campus Int Excellence, Campus Mare Nostrum, Ed 16,4a Pl,Campus Espinardo, E-30100 Murcia, Spain.
EM asta@um.es
RI Manadas, Bruno/A-7667-2012; Capela e Silva, Fernando/L-3261-2014;
   Coelho, Ana/H-8885-2012; Tvarijonaviciute, Asta/U-4303-2017; Anjo,
   Sandra/P-4479-2015; Lamy, Elsa/L-2309-2014
OI Manadas, Bruno/0000-0002-2087-4042; Coelho, Ana/0000-0002-6143-4203;
   Tvarijonaviciute, Asta/0000-0002-5323-5001; Mrljak,
   Vladimir/0000-0002-0723-7815; Anjo, Sandra/0000-0003-2180-3518; Lucena,
   Sonia/0000-0002-0607-5295; Lamy, Elsa/0000-0002-9370-1337
FU national funding through Portuguese Science Foundation (FCT)
   [UID/AGR/00115/2013]; Robles Chillida Foundation through its support
   program for the promotion on research in Health Sciences; European
   Regional Development Fund (ERDF) through the COMPETE 2020 - Operational
   Programme for Competitiveness and Internationalisation and Portuguese
   national funds via FCT [POCI-01-0145-FEDER-029311,
   POCI-01-0145-FEDER-007440, UID/NEU/04539/2013,
   POCI-01-0145-FEDER-016428, SAICTPAC/0010/2015,
   POCI-01-0145-FEDER-016795, PTDC/NEU-SCC/7051/2014]; National Mass
   Spectrometry Network (RNEM) [POCI-01-0145-FEDER-402-022125,
   ROTEIRO/0028/2013]; FCT [IF/01778/2013]; program "Juan de la Cierva
   Incorporacion" of `Ministerio de Economia y Competitividad', Spain
FX This paper was funded by national funding through Portuguese Science
   Foundation (FCT) under the project UID/AGR/00115/2013 (ICAAM -University
   of Evora) and by a grant from the Robles Chillida Foundation through its
   support program for the promotion on research in Health Sciences. This
   work was also financed by the European Regional Development Fund (ERDF)
   through the COMPETE 2020 - Operational Programme for Competitiveness and
   Internationalisation and Portuguese national funds via FCT, under
   projects: POCI-01-0145-FEDER-029311; POCI-01-0145-FEDER-007440 (ref.;
   UID/NEU/04539/2013), POCI-01-0145-FEDER-016428 (ref.:
   SAICTPAC/0010/2015), and POCI-01-0145-FEDER-016795 (ref.:
   PTDC/NEU-SCC/7051/2014); and by The National Mass Spectrometry Network
   (RNEM) under the contract POCI-01-0145-FEDER-402-022125 (ref.:
   ROTEIRO/0028/2013). The authors also had financial support from FCT in
   the form of Elsa Lamy's FCT investigator contract IF/01778/2013. Asta
   Tvarijonaviciute was supported by the program "Juan de la Cierva
   Incorporacion" of `Ministerio de Economia y Competitividad', Spain,
   through a postdoctoral grant. Funders had no role in study design, data
   collection, analysis, interpretation, or writing of the report.
CR Al-Rawi NH, 2011, DIABETES VASC DIS RE, V8, P22, DOI 10.1177/1479164110390243
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Bao LY, 2012, FEBS J, V279, P4576, DOI 10.1111/febs.12044
   Bodey AR, 1996, J SMALL ANIM PRACT, V37, P116, DOI 10.1111/j.1748-5827.1996.tb02358.x
   Castagnola M, 2017, ACTA OTORHINOLARYNGO, V37, P94, DOI 10.14639/0392-100X-1598
   Chauhan A, 2016, J CLIN LAB ANAL, V30, P649, DOI 10.1002/jcla.21917
   CHIKAMUNE T, 1995, J VET MED SCI, V57, P595, DOI 10.1292/jvms.57.595
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Giacco F, 2010, CIRC RES, V107, P1058, DOI 10.1161/CIRCRESAHA.110.223545
   Gillet LC, 2012, MOL CELL PROTEOMICS, V11, DOI 10.1074/mcp.O111.016717
   Goodson JM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0098799
   Guo X, 2012, ACTA PHARM SIN B, V2, P358, DOI 10.1016/j.apsb.2012.06.002
   Hamzah S. A., 2018, KURDISTAN J APPL RES, V3, P58
   Jensen-Jarolim E, 2016, ALLERGY, V71, P286, DOI 10.1111/all.12797
   Laflamme D, 1997, VET CLIN N AM-SMALL, V27, P1561, DOI 10.1016/S0195-5616(97)50139-2
   Law IKM, 2010, DIABETES, V59, P872, DOI 10.2337/db09-1541
   Lucena S., 2018, BIO MED RES INT, P1
   Lund E. M., 2006, International Journal of Applied Research in Veterinary Medicine, V4, P177
   Nakhjavani M, 2013, META GENE, V1, P1, DOI 10.1016/j.mgene.2013.09.002
   Pasha S, 2018, PROTEOMICS, V18, DOI 10.1002/pmic.201700293
   Piantedosi D, 2016, VET J, V216, P72, DOI 10.1016/j.tvjl.2016.07.002
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Sennels L, 2009, BMC BIOINFORMATICS, V10, DOI 10.1186/1471-2105-10-179
   Shi P, 2015, PLOS ONE, V10
   Simmons RK, 2010, DIABETOLOGIA, V53, P600, DOI 10.1007/s00125-009-1620-4
   Tang WH, 2008, J PROTEOME RES, V7, P3661, DOI 10.1021/pr070492f
   Torres SMF, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0191307
   Tvarijonaviciute A, 2019, VET J, V244, P51, DOI 10.1016/j.tvjl.2018.12.006
   Tvarijonaviciute  A., 2016, BMC VET RES, V12
   Tvarijonaviciute  A., 2014, VET CLIN PATHOL, V43
   Tvarijonaviciute A, 2012, BMC VET RES, V8, DOI 10.1186/1746-6148-8-147
   Velladath S.U., 2011, WEBMED CENTRAL CLIN, V2
   Verkest KR, 2011, DOMEST ANIM ENDOCRIN, V41, P24, DOI 10.1016/j.domaniend.2011.02.001
   Verkest KR, 2014, VET J, V199, P24, DOI 10.1016/j.tvjl.2013.09.057
   Xia Jianguo, 2016, Curr Protoc Bioinformatics, V55, DOI 10.1002/cpbi.11
   Xu YZ, 2005, AM J PHYSIOL-RENAL, V289, pF1040, DOI 10.1152/ajprenal.00076.2005
NR 36
TC 12
Z9 12
U1 0
U2 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1874-3919
EI 1876-7737
J9 J PROTEOMICS
JI J. Proteomics
PD JUN 15
PY 2019
VL 201
BP 65
EP 72
DI 10.1016/j.jprot.2019.04.010
PG 8
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA HZ9ED
UT WOS:000469157700007
PM 30991157
OA Green Published
DA 2025-06-11
ER

PT J
AU Regnault, C
   Usal, M
   Veyrenc, S
   Couturier, K
   Batandier, C
   Bulteau, AL
   Lejon, D
   Sapin, A
   Combourieu, B
   Chetiveaux, M
   Le May, C
   Lafond, T
   Raveton, M
   Reynaud, S
AF Regnault, Christophe
   Usal, Marie
   Veyrenc, Sylvie
   Couturier, Karine
   Batandier, Cecile
   Bulteau, Anne-Laure
   Lejon, David
   Sapin, Alexandre
   Combourieu, Bruno
   Chetiveaux, Maud
   Le May, Cedric
   Lafond, Thomas
   Raveton, Muriel
   Reynaud, Stephane
TI Unexpected metabolic disorders induced by endocrine disruptors in
   Xenopus tropicalis provide new lead for understanding amphibian
   decline
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE endocrine disruptors; metabolic syndrome; transgenerational; amphibian
   population decline; Xenopus tropicalis
ID NONALCOHOLIC FATTY LIVER; BISPHENOL-A EXPOSURE; ENDOPLASMIC-RETICULUM
   STRESS; THYROID-HORMONE; INSULIN-RESISTANCE; NUCLEAR RECEPTORS;
   AROMATASE EXPRESSION; METAMORPHOSIS ASSAY; HERBICIDE ATRAZINE;
   GLUCOSE-METABOLISM
AB Despite numerous studies suggesting that amphibians are highly sensitive to endocrine disruptors (EDs), both their role in the decline of populations and the underlying mechanisms remain unclear. This study showed that frogs exposed throughout their life cycle to ED concentrations low enough to be considered safe for drinking water, developed a prediabetes phenotype and, more commonly, a metabolic syndrome. Female Xenopus tropicalis exposed from tadpole stage to benzo(a) pyrene or triclosan at concentrations of 50 ng.L-1 displayed glucose intolerance syndrome, liver steatosis, liver mitochondrial dysfunction, liver transcriptomic signature, and pancreatic insulin hypersecretion, all typical of a prediabetes state. This metabolic syndrome led to progeny whose metamorphosis was delayed and occurred while the individuals were both smaller and lighter, all factors that have been linked to reduced adult recruitment and likelihood of reproduction. We found that F-1 animals did indeed have reduced reproductive success, demonstrating a lower fitness in ED-exposed Xenopus. Moreover, after 1 year of depuration, Xenopus that had been exposed to benzo(a) pyrene still displayed hepatic disorders and a marked insulin secretory defect resulting in glucose intolerance. Our results demonstrate that amphibians are highly sensitive to EDs at concentrations well below the thresholds reported to induce stress in other vertebrates. This study introduces EDs as a possible key contributing factor to amphibian population decline through metabolism disruption. Overall, our results show that EDs cause metabolic disorders, which is in agreement with epidemiological studies suggesting that environmental EDs might be one of the principal causes of metabolic disease in humans.
C1 [Regnault, Christophe; Usal, Marie; Veyrenc, Sylvie; Raveton, Muriel; Reynaud, Stephane] Univ Savoie Mt Blanc, Univ Grenoble Alpes, CNRS, LECA, F-38000 Grenoble, France.
   [Couturier, Karine; Batandier, Cecile] Univ Grenoble Alpes, INSERM, LBFA, F-38000 Grenoble, France.
   [Bulteau, Anne-Laure] Univ Lyon 1, Inst Genom Fonct Lyon, CNRS, UMR 5242,Ecole Normale Super Lyon, F-69000 Lyon, France.
   [Lejon, David; Sapin, Alexandre; Combourieu, Bruno] Rovaltain Res Co, F-26300 Alixan, France.
   [Chetiveaux, Maud; Le May, Cedric] Univ Nantes, Plate Forme Therassay, Inst Thorax, INSERM,CNRS, F-44007 Nantes, France.
   [Lafond, Thomas] Univ Rennes 1, Ctr Ressources Biol Xenopes, CNRS, Unite Mixte Serv 3387, F-35042 Rennes, France.
C3 Universite Savoie Mont Blanc; Communaute Universite Grenoble Alpes;
   Universite Grenoble Alpes (UGA); Centre National de la Recherche
   Scientifique (CNRS); Communaute Universite Grenoble Alpes; Universite
   Grenoble Alpes (UGA); Institut National de la Sante et de la Recherche
   Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS);
   CNRS - National Institute for Biology (INSB); CHU Lyon; Ecole Normale
   Superieure de Lyon (ENS de LYON); Universite Claude Bernard Lyon 1;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Nantes Universite; CHU de Nantes; Centre National de la Recherche
   Scientifique (CNRS); Universite de Rennes; Centre National de la
   Recherche Scientifique (CNRS)
RP Reynaud, S (corresponding author), Univ Savoie Mt Blanc, Univ Grenoble Alpes, CNRS, LECA, F-38000 Grenoble, France.
EM stephane.reynaud@univ-grenoble-alpes.fr
RI Le May, cedric/D-2691-2009; bulteau, anne-laure/AAN-4004-2020; Raveton,
   Muriel/K-1403-2013; Reynaud, Stephane/H-5493-2013
OI Reynaud, Stephane/0000-0003-0248-0602; veyrenc,
   sylvie/0000-0003-2894-3820
FU Communaute d'Universites et Etablissements Universite Grenoble-Alpes
   Initiatives de Recherche Strategiques Initiatives d'Excellence Grant;
   Federative Structure Environnemental and Systems Biology (BEeSy) of the
   Grenoble-Alpes University; French Ministry of Higher Education and
   Research; Region Auvergne-Rhone-Alpes
FX We thank Kim Barrett (Version Originale) and Oliver Ross
   (XpertScientific) for the English review of the revised manuscript. This
   work was funded by Communaute d'Universites et Etablissements Universite
   Grenoble-Alpes Initiatives de Recherche Strategiques Initiatives
   d'Excellence Grant and by the Federative Structure Environnemental and
   Systems Biology (BEeSy) of the Grenoble-Alpes University. C.R. received
   funding from the French Ministry of Higher Education and Research. M.U.
   was funded by the Region Auvergne-Rhone-Alpes.
CR Alonso-Magdalena P, 2010, ENVIRON HEALTH PERSP, V118, P1243, DOI 10.1289/ehp.1001993
   [Anonymous], 2012, State of the science of endocrine disrupting chemicals: Summary for decision-makers
   [Anonymous], 2003, GUID DRINK WAT QUAL, VThird
   Bechmann LP, 2012, J HEPATOL, V56, P952, DOI 10.1016/j.jhep.2011.08.025
   Bensellam M, 2016, DIABETOLOGIA, V59, P1492, DOI 10.1007/s00125-016-3947-y
   Blair BD, 2013, CHEMOSPHERE, V93, P2116, DOI 10.1016/j.chemosphere.2013.07.057
   Bolger AM, 2014, BIOINFORMATICS, V30, P2114, DOI 10.1093/bioinformatics/btu170
   BRISMAR K, 1994, J CLIN ENDOCR METAB, V79, P872, DOI 10.1210/jc.79.3.872
   Bulteau AL, 2003, BIOCHEMISTRY-US, V42, P14846, DOI 10.1021/bi0353979
   Bulteau AL, 2002, ARCH BIOCHEM BIOPHYS, V397, P298, DOI 10.1006/abbi.2001.2663
   Burri L, 2010, PPAR RES, V2010, DOI 10.1155/2010/542359
   Canada H, 2016, GUID CAN DRINK WAT Q
   Carey C, 1999, DEV COMP IMMUNOL, V23, P459, DOI 10.1016/S0145-305X(99)00028-2
   Casals-Casas C, 2011, ANNU REV PHYSIOL, V73, P135, DOI 10.1146/annurev-physiol-012110-142200
   Cave MC, 2016, BBA-GENE REGUL MECH, V1859, P1083, DOI 10.1016/j.bbagrm.2016.03.002
   Cevasco A, 2008, COMP BIOCHEM PHYS C, V147, P241, DOI 10.1016/j.cbpc.2007.10.001
   Chai LH, 2016, ECOTOXICOLOGY, V25, P1600, DOI 10.1007/s10646-016-1715-x
   Chen JL, 2014, J LIPID RES, V55, P32, DOI 10.1194/jlr.M039453
   Chevalier N, 2015, DIABETES METAB, V41, P107, DOI 10.1016/j.diabet.2014.09.005
   Chevalier N, 2015, REV ENDOCR METAB DIS, V16, P299, DOI 10.1007/s11154-016-9333-8
   Chevalier N, 2016, PRESSE MED, V45, P88, DOI 10.1016/j.lpm.2015.08.008
   Crump D, 2002, ENVIRON HEALTH PERSP, V110, P1199, DOI 10.1289/ehp.021101199
   de Vito J, 1999, J HERPETOL, V33, P504
   DiCroce L, 1997, PFLUG ARCH EUR J PHY, V435, P107, DOI 10.1007/s004240050489
   Duarte-Guterman P, 2014, GEN COMP ENDOCR, V203, P69, DOI 10.1016/j.ygcen.2014.03.015
   DUNNETT CW, 1955, J AM STAT ASSOC, V50, P1096, DOI 10.2307/2281208
   Fan WQ, 2007, ENVIRON HEALTH PERSP, V115, P720, DOI 10.1289/ehp.9758
   Fan W, 2007, BIOCHEM BIOPH RES CO, V355, P1012, DOI 10.1016/j.bbrc.2007.02.062
   Fedorenkova A, 2012, ENVIRON TOXICOL CHEM, V31, P1416, DOI 10.1002/etc.1831
   Garait B, 2005, FREE RADICAL BIO MED, V39, P1249, DOI 10.1016/j.freeradbiomed.2005.06.026
   Hammond SA, 2015, GEN COMP ENDOCR, V219, P6, DOI 10.1016/j.ygcen.2014.12.001
   Hayes T, 2002, NATURE, V419, P895, DOI 10.1038/419895a
   Hayes TB, 2010, J EXP BIOL, V213, P921, DOI 10.1242/jeb.040865
   Hayes TB, 2002, P NATL ACAD SCI USA, V99, P5476, DOI 10.1073/pnas.082121499
   Hayes TB, 2006, ENVIRON HEALTH PERSP, V114, P134, DOI 10.1289/ehp.8067
   Hayes TB, 2006, ENVIRON HEALTH PERSP, V114, P40, DOI 10.1289/ehp.8051
   Hayes TB, 2011, J STEROID BIOCHEM, V127, P64, DOI 10.1016/j.jsbmb.2011.03.015
   Hayes TB, 2010, P NATL ACAD SCI USA, V107, P4612, DOI 10.1073/pnas.0909519107
   Helbing Caren C., 2012, Frontiers in Genetics, V3, P37, DOI 10.3389/fgene.2012.00037
   Hinther A, 2011, ENVIRON SCI TECHNOL, V45, P5395, DOI 10.1021/es1041942
   Hothorn LA, 2016, COMMUN STAT-THEOR M, V45, P3332, DOI 10.1080/03610926.2014.902225
   Huang DW, 2009, NUCLEIC ACIDS RES, V37, P1, DOI 10.1093/nar/gkn923
   Jiang Y, 2014, TOXICOL LETT, V228, P85, DOI 10.1016/j.toxlet.2014.04.013
   Kaplan M, 2009, NATURE, DOI [10.1038/news.2009.1048, DOI 10.1038/NEWS.2009.1048]
   Kasuga M, 2006, J CLIN INVEST, V116, P1756, DOI 10.1172/JCI29189
   Kiesecker JM, 2002, P NATL ACAD SCI USA, V99, P9900, DOI 10.1073/pnas.152098899
   Koliaki C, 2015, CELL METAB, V21, P739, DOI 10.1016/j.cmet.2015.04.004
   Langlois VS, 2010, GEN COMP ENDOCR, V166, P417, DOI 10.1016/j.ygcen.2009.11.004
   Lindström A, 2002, ENVIRON SCI TECHNOL, V36, P2322, DOI 10.1021/es0114254
   Lips KR, 2008, PLOS BIOL, V6, P441, DOI 10.1371/journal.pbio.0060072
   Michurina SV, 2016, WORLD J DIABETES, V7, P534, DOI 10.4239/wjd.v7.i19.534
   Miyata K, 2012, J TOXICOL PATHOL, V25, P1, DOI 10.1293/tox.25.1
   Mondul A, 2015, J NUTR, V145, P1687, DOI 10.3945/jn.115.210633
   Moyer BJ, 2016, TOXICOL APPL PHARM, V300, P13, DOI 10.1016/j.taap.2016.03.011
   Musso G, 2013, PROG LIPID RES, V52, P175, DOI 10.1016/j.plipres.2012.11.002
   Nagaya T, 2010, J HEPATOL, V53, P724, DOI 10.1016/j.jhep.2010.04.033
   Naik A, 2013, GENOMICS, V102, P84, DOI 10.1016/j.ygeno.2013.03.007
   Olivares-Rubio HF, 2015, ECOTOXICOLOGY, V24, P664, DOI 10.1007/s10646-014-1414-4
   Opitz R, 2005, ENVIRON TOXICOL CHEM, V24, P653, DOI 10.1897/04-214R.1
   Orton F, 2015, BIOL REV, V90, P1100, DOI 10.1111/brv.12147
   Otoda T, 2013, DIABETES, V62, P811, DOI 10.2337/db11-1652
   Pagliassotti MJ, 2016, METABOLISM, V65, P1238, DOI 10.1016/j.metabol.2016.05.002
   Paul KB, 2013, TOXICOL IN VITRO, V27, P2049, DOI 10.1016/j.tiv.2013.07.008
   Pei LM, 2006, NAT MED, V12, P1048, DOI 10.1038/nm1471
   Petersen G. I., 2007, STUDY ENHANCING ENDO
   Petersen KF, 2007, P NATL ACAD SCI USA, V104, P12587, DOI 10.1073/pnas.0705408104
   Regnault C, 2016, CHEMOSPHERE, V155, P519, DOI 10.1016/j.chemosphere.2016.04.047
   Regnault C, 2014, BMC GENOMICS, V15, DOI 10.1186/1471-2164-15-666
   Roelants K, 2007, P NATL ACAD SCI USA, V104, P887, DOI 10.1073/pnas.0608378104
   Saeed AI, 2003, BIOTECHNIQUES, V34, P374, DOI 10.2144/03342mt01
   Säfholm M, 2014, PHILOS T R SOC B, V369, DOI 10.1098/rstb.2013.0577
   Satyarengga Medha, 2017, AACE Clin Case Rep, V3, pe255, DOI 10.4158/EP161483.CR
   Schultz MM, 2012, ARCH ENVIRON CON TOX, V63, P114, DOI 10.1007/s00244-011-9748-x
   Showell C, 2009, COLD SPRING HARB PRO, V2009
   SMITH DC, 1987, ECOLOGY, V68, P344, DOI 10.2307/1939265
   Susiarjo M, 2015, ENDOCRINOLOGY, V156, P2049, DOI 10.1210/en.2014-2027
   Taft JD, 2018, TOXICOL SCI, V161, P196, DOI 10.1093/toxsci/kfx213
   Takahashi Y, 2014, WORLD J GASTROENTERO, V20, P15539, DOI 10.3748/wjg.v20.i42.15539
   Trapido M, 1996, HYDROBIOLOGIA, V338, P185, DOI 10.1007/BF00031723
   Trapnell C, 2012, NAT PROTOC, V7, P562, DOI 10.1038/nprot.2012.016
   Trapnell C, 2009, BIOINFORMATICS, V25, P1105, DOI 10.1093/bioinformatics/btp120
   United States Environmental Protection Agency, 2010, FED REG
   Urbatzka R, 2007, COMP BIOCHEM PHYS C, V144, P310, DOI 10.1016/j.cbpc.2006.10.008
   US Environmental Protection Agency, 2014, EDSP21 DASHB END DIS
   Wang F, 2018, CHEMOSPHERE, V193, P695, DOI 10.1016/j.chemosphere.2017.11.088
   Yamaguchi K, 2007, HEPATOLOGY, V45, P1366, DOI 10.1002/hep.21655
   Zhou Z, 2017, AQUAT TOXICOL, V191, P175, DOI 10.1016/j.aquatox.2017.08.009
NR 87
TC 46
Z9 52
U1 1
U2 58
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAY 8
PY 2018
VL 115
IS 19
BP E4416
EP E4425
DI 10.1073/pnas.1721267115
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GF0RQ
UT WOS:000431639100015
PM 29686083
OA Green Submitted, Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Belli, AA
   Gok, SO
   Akbaba, G
   Etgu, F
   Dogan, G
AF Akin Belli, Asli
   Ozbas Gok, Seyran
   Akbaba, Gulhan
   Etgu, Fatma
   Dogan, Gursoy
TI The relationship between rosacea and insulin resistance and metabolic
   syndrome
SO EUROPEAN JOURNAL OF DERMATOLOGY
LA English
DT Article
DE cardiovascular diseases; insulin resistance; metabolic syndrome; rosacea
ID ENDOPLASMIC-RETICULUM STRESS; CARDIOVASCULAR RISK-FACTORS; PEPTIDE
   LL-37; ER STRESS; INFLAMMASOME; PATHOGENESIS; ACTIVATION
AB Background: Rosacea is a chronic inflammatory skin disease affecting the face. A positive correlation has been found between rosacea and cardiovascular diseases. Objectives: We sought to investigate the relation between rosacea and metabolic syndrome (MS) and insulin resistance (IR). Materials and methods: Between January and June 2015, a case-control study including 47 age-, gender-, and body mass index (BMI)-matched rosacea patients and 50 controls was conducted. Demographic data, clinical features of rosacea patients, anthropometric measures, laboratory findings, blood pressure levels, BMI, smoking history, alcohol consumption, sports life, family history of cardiovascular disease, and presence of MS and IR were recorded. Results: Forty-seven rosacea patients (12 men and 35 women; age range: 35-68 years) and 50 controls (11 men and 39 women; age range: 38-78 years) were included in our study. Of 47 rosacea patients, 24 had erythematotelangiectatic type, 22 had papulopustular type, and one had phymatous type. Whereas the rate of IR was significantly higher in the rosacea group, there was no significant difference in the rate of MS between rosacea and the control group (p = 0.009 and p = 0.186, respectively). In addition, the rosacea group had significantly higher fasting blood glucose, total cholesterol, and systolic and diastolic blood pressure levels (p < 0.05). Mean levels of LDL, triglyceride, total cholesterol and CRP were significantly higher than in the control group (p < 0.05). Conclusion: Our findings suggest that there is a relationship between rosacea and IR and some parameters of cardiovascular risk factors. We recommend investigation of IR in rosacea patients.
C1 [Akin Belli, Asli; Dogan, Gursoy] Kocman Univ Training & Res Hosp, Dept Dermatol, Mugla, Turkey.
   [Ozbas Gok, Seyran] Artvin Hopa State Hosp, Dept Dermatol, Artvin, Turkey.
   [Akbaba, Gulhan] Mugla Sitki Kocman Univ Training & Res Hosp, Dept Endocrinol & Metab Dis, Mugla, Turkey.
   [Etgu, Fatma] Ardahan State Hosp, Dept Dermatol, Ardahan, Turkey.
C3 Artvin State Hospital; Hopa State Hospital; Ardahan State Hospital
RP Belli, AA (corresponding author), Kocman Univ Training & Res Hosp, Dept Dermatol, Mugla, Turkey.
EM dr_asliakin@hotmail.com
OI Etgu, Fatma/0000-0003-1214-3327
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Arias-Santiago S, 2011, AM J MED, V124, P543, DOI 10.1016/j.amjmed.2010.12.025
   Benachour H, 2009, NUTR METAB CARDIOVAS, V19, P720, DOI 10.1016/j.numecd.2009.01.001
   Bonomini F, 2008, HISTOL HISTOPATHOL, V23, P381, DOI 10.14670/HH-23.381
   Casas C, 2012, EXP DERMATOL, V21, P906, DOI 10.1111/exd.12030
   Crawford GH, 2004, J AM ACAD DERMATOL, V51, P327, DOI 10.1016/j.jaad.2004.03.030
   Cribier B., 2011, ANN DERMATOL VENER, V138, P184
   Duman N, 2014, J EUR ACAD DERMATOL, V28, P1165, DOI 10.1111/jdv.12234
   Edfeldt K, 2006, ARTERIOSCL THROM VAS, V26, P1551, DOI 10.1161/01.ATV.0000223901.08459.57
   Elssner A, 2004, J IMMUNOL, V172, P4987, DOI 10.4049/jimmunol.172.8.4987
   Gupta AK, 2005, J EUR ACAD DERMATOL, V19, P273, DOI 10.1111/j.1468-3083.2005.01216.x
   Hua TC, 2015, J AM ACAD DERMATOL, V73, P249, DOI 10.1016/j.jaad.2015.04.028
   Kim OK, 2015, ANN NUTR METAB, V67, P218, DOI 10.1159/000440905
   Kim S, 2014, INNATE IMMUN-LONDON, V20, P799, DOI 10.1177/1753425913508593
   Koczulla R, 2003, J CLIN INVEST, V111, P1665, DOI 10.1172/JCI200317545
   Luna-Luna M, 2015, ARCH MED RES, V46, P392, DOI 10.1016/j.arcmed.2015.05.007
   Meigs JB, 2007, DIABETES CARE, V30, P2529, DOI 10.2337/dc07-0817
   Melnik BC, 2015, ACTA DERM VENEREOL
   Melnik BC, 2014, EXP DERMATOL, V23, P868, DOI 10.1111/exd.12517
   Menu P, 2012, CELL DEATH DIS, V3, DOI 10.1038/cddis.2011.132
   Parodi A, 2014, AM J CLIN DERMATOL, V15, P371, DOI 10.1007/s40257-014-0074-8
   Rainer BM, 2015, J AM ACAD DERMATOL, V73, P604, DOI 10.1016/j.jaad.2015.07.009
   Salzer S, 2014, J DERMATOL SCI, V76, P173, DOI 10.1016/j.jdermsci.2014.09.002
   Steinhoff M, 2013, J AM ACAD DERMATOL, V69, pS15, DOI 10.1016/j.jaad.2013.04.045
   Takci Z, 2015, J EUR ACAD DERMATOL, V29, P367, DOI 10.1111/jdv.12556
   Two AM, 2015, J AM ACAD DERMATOL, V72, P749, DOI 10.1016/j.jaad.2014.08.028
   Wu H, 2015, INFLAMMATION, V38, P2076, DOI 10.1007/s10753-015-0189-y
   Yamasaki K, 2011, J INVEST DERM SYMP P, V15, P12, DOI 10.1038/jidsymp.2011.4
NR 28
TC 56
Z9 57
U1 0
U2 13
PU JOHN LIBBEY EUROTEXT LTD
PI MONTROUGE
PA 127 AVE DE LA REPUBLIQUE, 92120 MONTROUGE, FRANCE
SN 1167-1122
EI 1952-4013
J9 EUR J DERMATOL
JI Eur. J. Dermatol.
PD MAY-JUN
PY 2016
VL 26
IS 3
BP 260
EP 264
DI 10.1684/ejd.2016.2748
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA DP8YC
UT WOS:000378782900006
PM 27328660
DA 2025-06-11
ER

PT J
AU Radosavljevic, T
   Brankovic, M
   Samardzic, J
   Djuretic, J
   Vukicevic, D
   Vucevic, D
   Jakovljevic, V
AF Radosavljevic, Tatjana
   Brankovic, Milica
   Samardzic, Janko
   Djuretic, Jasmina
   Vukicevic, Dusan
   Vucevic, Danijela
   Jakovljevic, Vladimir
TI Altered Mitochondrial Function in MASLD: Key Features and Promising
   Therapeutic Approaches
SO ANTIOXIDANTS
LA English
DT Review
DE mitochondria; MASLD; MASH; mitochondrial dysfunction; metabolic
   syndrome; oxidative stress; mitochondrial quality control
ID STEATOTIC LIVER-DISEASE; TARGETED ANTIOXIDANT; LIPID-METABOLISM; HEPATIC
   STEATOSIS; CONTROLLED-TRIAL; MITO-TEMPO; DYSFUNCTION; MITOPHAGY; MICE;
   MECHANISMS
AB Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD), encompasses a range of liver conditions from steatosis to nonalcoholic steatohepatitis (NASH). Its prevalence, especially among patients with metabolic syndrome, highlights its growing global impact. The pathogenesis of MASLD involves metabolic dysregulation, inflammation, oxidative stress, genetic factors and, notably, mitochondrial dysfunction. Recent studies underscore the critical role of mitochondrial dysfunction in MASLD's progression. Therapeutically, enhancing mitochondrial function has gained interest, along with lifestyle changes and pharmacological interventions targeting mitochondrial processes. The FDA's approval of resmetirom for metabolic-associated steatohepatitis (MASH) with fibrosis marks a significant step. While resmetirom represents progress, further research is essential to understand MASLD-related mitochondrial dysfunction fully. Innovative strategies like gene editing and small-molecule modulators, alongside lifestyle interventions, can potentially improve MASLD treatment. Drug repurposing and new targets will advance MASLD therapy, addressing its increasing global burden. Therefore, this review aims to provide a better understanding of the role of mitochondrial dysfunction in MASLD and identify more effective preventive and treatment strategies.
C1 [Radosavljevic, Tatjana; Vucevic, Danijela] Univ Belgrade, Inst Pathophysiol Ljubodrag Buba Mihailovic, Fac Med, Belgrade 11000, Serbia.
   [Brankovic, Milica; Samardzic, Janko] Univ Belgrade, Inst Pharmacol Clin Pharmacol & Toxicol, Fac Med, Belgrade 11000, Serbia.
   [Djuretic, Jasmina] Univ Belgrade, Fac Pharm, Dept Pathobiol, Belgrade 11000, Serbia.
   [Vukicevic, Dusan] Uniklin Mannheim, Theodor Kutyer Ufer 1-3, D-68167 Mannheim, Germany.
   [Jakovljevic, Vladimir] Univ Kragujevac, Fac Med Sci, Dept Physiol, Svetozara Markovica 69, Kragujevac 34000, Serbia.
   [Jakovljevic, Vladimir] Univ Kragujevac, Ctr Excellence Study Redox Balance Cardiovasc & Me, Svetozara Markovica 69, Kragujevac 34000, Serbia.
   [Jakovljevic, Vladimir] First Moscow State Med Univ IM Sechenov, Dept Human Pathol, Trubetskaya St 8, Str 2, Moscow 119991, Russia.
C3 University of Belgrade; University of Belgrade; University of Belgrade;
   Ruprecht Karls University Heidelberg; University of Kragujevac;
   University of Kragujevac; Sechenov First Moscow State Medical University
RP Radosavljevic, T (corresponding author), Univ Belgrade, Inst Pathophysiol Ljubodrag Buba Mihailovic, Fac Med, Belgrade 11000, Serbia.
EM tatjana.radosavljevic@med.bg.ac.rs; milicabrankovic137@yahoo.com;
   jankomedico@yahoo.es; jasmina.djuretic@pharmacy.bg.ac.rs;
   vukdusan@hotmail.com; danijela.vucevic@med.bg.ac.rs;
   drvladakgbg@gmail.com
RI Radosavljević, Tatjana/AAE-2792-2020; Samardzic, Janko/H-7897-2019
OI Samardzic, Janko/0000-0002-8464-4924; Djuretic,
   Jasmina/0000-0002-8457-4962; Radosavljevic, Tatjana/0000-0002-1701-3313
FU Faculty of Medical Sciences, University of Kragujevac [JP 27/20];
   Ministry of Science, Technical Development, and Innovation of the
   Republic of Serbia [451-03-47/2023-01/200111, 451-03-66/2024-03/200110,
   451-03-65/2024-03/200161, 451-03-66/2024-03/200161]
FX This research was supported by the Faculty of Medical Sciences,
   University of Kragujevac (JP 27/20) and the Ministry of Science,
   Technical Development, and Innovation of the Republic of Serbia through
   Grant Agreements Nos. 451-03-47/2023-01/200111,
   451-03-66/2024-03/200110, 451-03-65/2024-03/200161, and
   451-03-66/2024-03/200161.
CR Akbari R, 2021, BMC PHARMACOL TOXICO, V22, DOI 10.1186/s40360-021-00524-8
   Ala M, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/1197061
   Allen ME, 2020, COMMUN BIOL, V3, DOI 10.1038/s42003-020-1101-3
   [Anonymous], 2020, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction (CHARM)
   Arumugam MK, 2023, BIOLOGY-BASEL, V12, DOI 10.3390/biology12101311
   Atici AE, 2023, FRONT CELL DEV BIOL, V11, DOI 10.3389/fcell.2023.1290046
   Augustyniak J, 2019, MOL NEUROBIOL, V56, P4346, DOI 10.1007/s12035-018-1368-2
   Belosludtsev KN, 2021, MITOCHONDRION, V59, P246, DOI 10.1016/j.mito.2021.06.008
   Belosludtseva NV, 2021, B EXP BIOL MED+, V171, P601, DOI [10.1007/s10517-021-05277-2, 10.47056/0365-9615-2021-171-5-572-576]
   Benova A, 2022, MOL METAB, V65, DOI 10.1016/j.molmet.2022.101598
   BioSpace, Inventiva Announces Positive Results from the Phase II, LEGEND, Proof-of-Concept Study Combining Lanifibranor with Empagliflozin in Patients with MASH/NASH and T2D
   Boeckmans J, 2019, PHARMACOL RES, V144, P377, DOI 10.1016/j.phrs.2019.04.016
   Caputo V, 2023, NUTRIENTS, V15, DOI 10.3390/nu15224757
   Casanova A, 2023, FRONT PHYSIOL, V14, DOI 10.3389/fphys.2023.1114231
   Chang N, 2024, SCI REP-UK, V14, DOI 10.1038/s41598-024-55923-8
   Chatfield KC, 2019, JACC-BASIC TRANSL SC, V4, P147, DOI 10.1016/j.jacbts.2018.12.005
   Chen JW, 2022, FRONT CELL NEUROSCI, V16, DOI 10.3389/fncel.2022.803718
   Chen MC, 2023, TOXICOL RES-UK, DOI 10.1093/toxres/tfad007
   Chen W, 2023, SIGNAL TRANSDUCT TAR, V8, DOI 10.1038/s41392-023-01547-9
   Chen WJ, 2024, NPJ PRECIS ONCOL, V8, DOI 10.1038/s41698-024-00536-7
   Cheung KS, 2024, HEPATOLOGY, V80, P916, DOI 10.1097/HEP.0000000000000855
   Cho K, 2022, OBES REV, V23, DOI 10.1111/obr.13464
   Chu QF, 2021, ANAL CELL PATHOL, V2021, DOI 10.1155/2021/8900122
   Chun HJ, 2023, METABOLISM, V145, DOI 10.1016/j.metabol.2023.155612
   Civiletto G, 2015, CELL METAB, V21, P845, DOI 10.1016/j.cmet.2015.04.016
   Clemente-Suárez VJ, 2023, NUTRIENTS, V15, DOI 10.3390/nu15122749
   Clinicaltrials.gov, A Study of MSDC-0602K to Assess Glycemic Control and Cardiovascular Outcomes in Patients with Pre-T2D or T2D and NAFLD/NASH
   Corona JC, 2016, FREE RADICAL BIO MED, V100, P153, DOI 10.1016/j.freeradbiomed.2016.06.023
   Da Dalt L, 2024, CARDIOVASC RES, V119, P2917, DOI 10.1093/cvr/cvad169
   Dabravolski SA, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23105371
   Dabravolski SA, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22094459
   de Maranon AM, 2022, REDOX BIOL, V53, DOI 10.1016/j.redox.2022.102342
   Ding QQ, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10092463
   Diniz MS, 2022, DIABETOLOGY, V3, P583, DOI 10.3390/diabetology3040044
   Doblado L, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22083903
   Docherty S, 2022, BMC SPORTS SCI MED R, V14, DOI 10.1186/s13102-022-00397-2
   Dong YZ, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11050893
   Dorn GW, 2013, TOXICOL PATHOL, V41, P227, DOI 10.1177/0192623312466961
   Farzanegi P, 2019, EUR J SPORT SCI, V19, P994, DOI 10.1080/17461391.2019.1571114
   FDA, Approves First Treatment for COVID-19
   Francque SM, 2021, NEW ENGL J MED, V385, P1547, DOI 10.1056/NEJMoa2036205
   Fujisawa K, 2009, BIOCHEM BIOPH RES CO, V379, P43, DOI 10.1016/j.bbrc.2008.11.141
   Gager GM, 2021, BIOMED PHARMACOTHER, V143, DOI 10.1016/j.biopha.2021.112169
   Galloway CA, 2014, AM J PHYSIOL-GASTR L, V307, pG632, DOI 10.1152/ajpgi.00182.2014
   Gao S, 2021, TRENDS CELL BIOL, V31, P62, DOI 10.1016/j.tcb.2020.09.008
   Garcia-Martinez I, 2016, J CLIN INVEST, V126, P859, DOI 10.1172/JCI83885
   Geng Y, 2020, BBA-MOL BASIS DIS, V1866, DOI 10.1016/j.bbadis.2019.165621
   Genua Idoia, 2024, Diabetes Spectr, V37, P48, DOI 10.2337/dsi23-0012
   Glick D, 2012, MOL CELL BIOL, V32, P2570, DOI 10.1128/MCB.00167-12
   Gong F, 2019, BIOCHEM BIOPH RES CO, V514, P593, DOI 10.1016/j.bbrc.2019.04.069
   Goyal O, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-78342-x
   Green A, 2022, FRONT CELL DEV BIOL, V10, DOI 10.3389/fcell.2022.1010232
   Grygiel-Górniak B, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-17
   Gui ZC, 2024, BIOFACTORS, V50, P145, DOI 10.1002/biof.1998
   Harris J, 2018, MITOCHONDRION, V41, P2, DOI 10.1016/j.mito.2017.10.009
   Harrison SA, 2024, NEW ENGL J MED, V390, P497, DOI 10.1056/NEJMoa2309000
   Heinle JW, 2023, NUTRIENTS, V15, DOI 10.3390/nu15112452
   Hodges WT, 2022, J BIOL CHEM, V298, DOI 10.1016/j.jbc.2021.101554
   García-Berumen CI, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.1089130
   Hernández-Alvarez MI, 2019, CELL, V177, P881, DOI 10.1016/j.cell.2019.04.010
   Jang H, 2024, JAMA INTERN MED, V184, P375, DOI 10.1001/jamainternmed.2023.8029
   Jiang Y, 2021, LIPIDS HEALTH DIS, V20, DOI 10.1186/s12944-021-01461-5
   Jiang YX, 2024, LIPIDS HEALTH DIS, V23, DOI 10.1186/s12944-024-02092-2
   Jomova K, 2023, ARCH TOXICOL, V97, P2499, DOI 10.1007/s00204-023-03562-9
   Kalavalapalli S, 2018, AM J PHYSIOL-ENDOC M, V315, pE163, DOI 10.1152/ajpendo.00023.2018
   Kamm DR, 2021, J BIOL CHEM, V296, DOI 10.1016/j.jbc.2021.100807
   Karim Gres, 2023, touchREV Endocrinol, V19, P60, DOI 10.17925/EE.2023.19.1.60
   Karimi A, 2023, J FOOD BIOCHEM, V2023, DOI 10.1155/2023/7277060
   Karkucinska-Wieckowska A, 2022, EUR J CLIN INVEST, V52, DOI 10.1111/eci.13622
   Kawamura T, 2018, ANTIOXIDANTS-BASEL, V7, DOI 10.3390/antiox7090119
   Kent AC, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/6626484
   Koizumi T, 2023, FRONT CARDIOVASC MED, V10, DOI 10.3389/fcvm.2023.1005408
   Kowalczyk P, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222413384
   Kowdley KV, 2024, NEW ENGL J MED, V390, P795, DOI 10.1056/NEJMoa2306185
   Krawczyk M, 2023, BIOMOLECULES, V13, DOI 10.3390/biom13091402
   Kumar DP, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-66458-z
   Kyriakoudi S, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22094617
   Lambona C, 2024, J MED CHEM, V67, P1662, DOI 10.1021/acs.jmedchem.3c01979
   LaMoia TE, 2022, P NATL ACAD SCI USA, V119, DOI 10.1073/pnas.2122287119
   Lazarus JV, 2024, NAT MED, V30, P3402, DOI 10.1038/s41591-024-02958-z
   Lebovitz HE, 2019, CURR DIABETES REP, V19, DOI 10.1007/s11892-019-1270-y
   Lee HK, 2023, NAT COMMUN, V14, DOI 10.1038/s41467-023-42564-0
   Lee YM, 2006, NUTRITION, V22, P956, DOI 10.1016/j.nut.2005.12.014
   Legaki AI, 2022, CURR OBES REP, V11, P126, DOI 10.1007/s13679-022-00473-1
   Li LR, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.589273
   Li SD, 2024, ANN HEPATOL, V29, DOI 10.1016/j.aohep.2023.101174
   Li SA, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/6617256
   Liu JT, 2023, J HEMATOL ONCOL, V16, DOI 10.1186/s13045-023-01512-7
   Luo YF, 2021, IMMUN INFLAMM DIS, V9, P59, DOI 10.1002/iid3.391
   Lyu Y, 2023, EUR J PHARMACOL, V942, DOI 10.1016/j.ejphar.2023.175531
   Ma Y, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11010091
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Makino A, 2011, AM J PHYSIOL-REG I, V300, pR1296, DOI 10.1152/ajpregu.00437.2010
   Martínez-Rojas MA, 2024, JCI INSIGHT, V9, DOI 10.1172/jci.insight.173675
   Medina-Remón A, 2017, BRIT J CLIN PHARMACO, V83, P114, DOI 10.1111/bcp.12986
   Mellemkjær A, 2024, EUR J INTERN MED, V122, P28, DOI 10.1016/j.ejim.2023.11.012
   Meng H, 2019, FRONT AGING NEUROSCI, V11, DOI 10.3389/fnagi.2019.00313
   Miryan M, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1062008
   Morishita A, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0261310
   Natap.org, RESOLVE-IT Phase 3 of Elafibranor in NASH: Final Results of the Week 72 Interim Surrogate Efficacy Analysis
   Ndakotsu A, 2022, CUREUS J MED SCIENCE, V14, DOI 10.7759/cureus.25380
   Newman NJ, 2023, BRAIN, V146, P1328, DOI 10.1093/brain/awac421
   Nie QL, 2024, J TRANSL MED, V22, DOI 10.1186/s12967-024-05011-2
   Ore A, 2019, MEDICINA-LITHUANIA, V55, DOI 10.3390/medicina55020026
   Oskuye ZZ, 2024, HELIYON, V10, DOI 10.1016/j.heliyon.2024.e28158
   Pawlak M, 2015, J HEPATOL, V62, P720, DOI 10.1016/j.jhep.2014.10.039
   Perazza F, 2024, METABOLITES, V14, DOI 10.3390/metabo14040186
   Pharaoh G, 2023, GEROSCIENCE, V45, P3529, DOI 10.1007/s11357-023-00861-y
   Phoolchund AGS, 2024, CANCERS, V16, DOI 10.3390/cancers16020259
   Pipitone RM, 2023, THER ADV ENDOCRINOL, V14, DOI 10.1177/20420188221145549
   Popov LD, 2020, J CELL MOL MED, V24, P4892, DOI 10.1111/jcmm.15194
   Razzak IA, 2024, J CLIN MED, V13, DOI 10.3390/jcm13030880
   Rey V., 2023, Kinases and Phosphatases, V1, P181, DOI [10.3390/kinasesphosphatases1030012, DOI 10.3390/KINASESPHOSPHATASES1030012]
   Rezaei A, 2023, CRYOBIOLOGY, V110, P36, DOI 10.1016/j.cryobiol.2022.12.019
   Rinella ME, 2023, J HEPATOL, V79, P1542, DOI 10.1016/j.jhep.2023.06.003
   Roca-Agujetas V, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/3809308
   Rodríguez AG, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24054394
   Sandoval-Acuña C, 2014, ARCH BIOCHEM BIOPHYS, V559, P75, DOI 10.1016/j.abb.2014.05.017
   Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929
   Seidemann L, 2021, MOLECULES, V26, DOI 10.3390/molecules26041156
   Serviddio G, 2010, J PHARMACOL EXP THER, V332, P922, DOI 10.1124/jpet.109.161612
   Shetty S, 2021, MITOCHONDRION, V58, P123, DOI 10.1016/j.mito.2021.03.001
   Shin S, 2023, J OBES METAB SYNDR, V32, P289
   Skov V, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002466
   Suga T, 2020, WORLD J HEPATOL, V12, P350, DOI 10.4254/wjh.v12.i7.350
   Sulaimon LA, 2022, ADV REDOX RES, V5, DOI 10.1016/j.arres.2022.100037
   Tang JX, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21113820
   Teodoro JS, 2013, MITOCHONDRION, V13, P637, DOI 10.1016/j.mito.2013.09.002
   Undamatla R, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-34710-x
   Van Meeteren MJW, 2020, EXPERT OPIN INV DRUG, V29, P117, DOI 10.1080/13543784.2020.1668375
   Varanita T, 2015, CELL METAB, V21, P834, DOI 10.1016/j.cmet.2015.05.007
   Veskovic M, 2019, EUR J PHARMACOL, V848, P39, DOI 10.1016/j.ejphar.2019.01.043
   Vial G, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00294
   Wang PY, 2010, CIRC RES, V106, P911, DOI 10.1161/CIRCRESAHA.109.206185
   Wang PF, 2022, MEDIAT INFLAMM, V2022, DOI 10.1155/2022/6394199
   Wang SL, 2023, SIGNAL TRANSDUCT TAR, V8, DOI 10.1038/s41392-023-01503-7
   Wang SY, 2022, FRONT CELL DEV BIOL, V10, DOI 10.3389/fcell.2022.848214
   Wang SW, 2020, NUTR DIABETES, V10, DOI 10.1038/s41387-020-00130-3
   Wang YY, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10020210
   Wei WX, 2024, CELL MOL LIFE SCI, V81, DOI 10.1007/s00018-023-05093-z
   Williamson J, 2020, REDOX BIOL, V36, DOI 10.1016/j.redox.2020.101673
   Xia WM, 2024, NAT METAB, V6, P273, DOI 10.1038/s42255-024-00978-0
   Xu J, 2020, BBA-MOL BASIS DIS, V1866, DOI 10.1016/j.bbadis.2020.165756
   Xu JQ, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.796207
   Yamada T, 2022, ISCIENCE, V25, DOI 10.1016/j.isci.2022.103996
   Yang KM, 2023, NUTRIENTS, V15, DOI 10.3390/nu15183970
   Yoo J, 2023, DIABETES, V72, DOI 10.2337/db23-1599-P
   Young C.F., 2023, Endocrines, V4, P630, DOI [10.3390/endocrines4030045, DOI 10.3390/ENDOCRINES4030045]
   Zang MW, 2022, TRENDS ENDOCRIN MET, V33, P801, DOI 10.1016/j.tem.2022.10.004
   Zerihun M, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24065785
   Zhang MJ, 2023, BIOMED PHARMACOTHER, V167, DOI 10.1016/j.biopha.2023.115623
   Zhang T, 2023, LIFE SCI, V329, DOI 10.1016/j.lfs.2023.121943
   Zhao FJ, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.749756
   Zheng P, 2023, J CLIN BIOCHEM NUTR, V73, P61, DOI 10.3164/jcbn.22-73
   Zhou T, 2019, REDOX BIOL, V21, DOI 10.1016/j.redox.2019.101120
   Zhu W, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10123306
   Zou YY, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1162485
NR 157
TC 11
Z9 11
U1 13
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD AUG
PY 2024
VL 13
IS 8
AR 906
DI 10.3390/antiox13080906
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA E8V3I
UT WOS:001305716300001
PM 39199152
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Colle, R
   de Larminat, D
   Rotenberg, S
   Hozer, F
   Hardy, P
   Verstuyft, C
   Fève, B
   Corruble, E
AF Colle, R.
   de Larminat, D.
   Rotenberg, S.
   Hozer, F.
   Hardy, P.
   Verstuyft, C.
   Feve, B.
   Corruble, E.
TI PPAR-γ Agonists for the Treatment of Major Depression: A Review
SO PHARMACOPSYCHIATRY
LA English
DT Review
DE major depression; PPAR-gamma agonists; pioglitazone; efficacy; safety
ID TYPE-2 DIABETES-MELLITUS; PROLIFERATOR-ACTIVATED RECEPTORS; PIOGLITAZONE
   ADJUNCTIVE THERAPY; METABOLIC SYNDROME; DOUBLE-BLIND; MACROVASCULAR
   EVENTS; BIPOLAR DISORDER; CLINICAL-TRIAL; METAANALYSIS;
   THIAZOLIDINEDIONES
AB Introduction Selective agonists of the nuclear transcription factor peroxisome proliferator-activated receptor-gamma (PPAR-gamma) are used for the treatment of type 2 diabetes. We reviewed their efficacy and safety for the treatment of major depression and the association of their potential antidepressant effects with changes in biomarkers of metabolism and inflammation.
   Methods From 8 studies, 4 open-label trials, and 4 randomized controlled trials (RCT) (3 vs. placebo and 1 vs. metformin), 448 patients with major depression were included, of which 209 patients received PPAR-gamma agonists (pioglitazone or rosiglitazone) for 6-12 weeks, either alone or in add-on therapy to conventional treatments.
   Results PPAR-gamma agonists have antidepressant effects in the 4 open-label studies and in 3 out of 4 RCT. No major adverse event was reported. Improvement in depression scores was associated with improvement in 3 biomarkers of insulin resistance (homeostatic model assessment [HOMA-IR], oral glucose tolerance test, and fasting plasma glucose) and 1 biomarker of inflammation (interleukin-6) among 21 biomarkers studied.
   Conclusion PPAR-gamma agonists may have antidepressant properties, which need to be assessed in further studies of major depressive episodes.
C1 [Colle, R.; de Larminat, D.; Rotenberg, S.; Hozer, F.; Hardy, P.; Verstuyft, C.; Corruble, E.] Univ Paris Sud, Le Kremlin Bicetre, France.
   [Colle, R.; de Larminat, D.; Rotenberg, S.; Hozer, F.; Hardy, P.; Corruble, E.] INSERM, UMRS 1178, Le Kremlin Bicetre, France.
   [Colle, R.; de Larminat, D.; Rotenberg, S.; Hozer, F.; Hardy, P.; Verstuyft, C.; Corruble, E.] Hop Univ Paris Sud, Hop Bicetre, Assistance Publ Hop Paris, Le Kremlin Bicetre, France.
   [Colle, R.; de Larminat, D.; Rotenberg, S.; Hozer, F.; Hardy, P.; Corruble, E.] Dept Psychiat, Le Kremlin Bicetre, France.
   [Verstuyft, C.] INSERM, Ctr IMVA, UMR S1184, F-75654 Paris 13, France.
   [Verstuyft, C.] Serv Genet Mol Pharmacogenet & Hormonol, Paris, France.
   [Feve, B.] Sorbonne Univ, Univ Pierre & Marie Curie, INSERM, Ctr Rech St Antoine,UMR S938, Paris, France.
   [Feve, B.] Inst Hosp Univ ICAN, Paris, France.
   [Feve, B.] Hop St Antoine, Assistance Publ Hop Paris, Serv Endocrinol, Paris, France.
C3 Universite Paris Saclay; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Paris Cite; Universite Paris
   Saclay; Assistance Publique Hopitaux Paris (APHP); Universite Paris
   Cite; Hopital Universitaire Saint-Louis - APHP; Hopital Universitaire
   Antoine-Beclere - APHP; Hopital Universitaire Bicetre - APHP; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Sorbonne
   Universite; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Assistance Publique Hopitaux Paris (APHP); Sorbonne
   Universite; Hopital Universitaire Saint-Antoine - APHP; Universite Paris
   Cite; Hopital Universitaire Saint-Louis - APHP
RP Colle, R (corresponding author), CHU Bicetre, Dept Psychiat, 78 Rue Gen Leclerc, Le Kremlin Bicetre, France.
EM romaincolle@hotmail.com
RI verstuyft, celine/AAU-3343-2021; Colle, Romain/IQV-1876-2023
OI verstuyft, celine/0000-0002-8534-224X; Hozer, Franz/0000-0003-4592-0532;
   Colle, Romain/0000-0002-2549-4495; Feve, Bruno/0000-0001-6577-9009
FU Astra-Zeneca; Sanofi; NovoNordisk; MSD
FX Romain Colle, Delphine de Larminat, Samuel Rotenberg, Franz Hozer,
   Patrick Hardy, Celine Verstuyft, and Emmanuelle Corruble declare no
   potential conflict of interest. Bruno Feve has received conference fees
   for Astra-Zeneca, Sanofi, NovoNordisk, and MSD and consulting fees from
   Sanofi.
CR Ahmed AAE, 2009, BEHAV PHARMACOL, V20, P635, DOI 10.1097/FBP.0b013e328331b9bf
   Bellucci PN, 2016, J PHARM PRACT
   Brundin P, 2015, NAT REV NEUROL, V11, P553, DOI 10.1038/nrneurol.2015.150
   Carta AR, 2013, CURR DRUG TARGETS, V14, P743, DOI 10.2174/1389450111314070004
   Chen YC, 2012, MOL NEUROBIOL, V46, P114, DOI 10.1007/s12035-012-8259-8
   Cimini A, 2008, STEM CELL REV, V4, P293, DOI 10.1007/s12015-008-9024-2
   Consoli A, 2013, DIABETES OBES METAB, V15, P967, DOI 10.1111/dom.12101
   Corruble E, 2015, WORLD PSYCHIATRY, V14, P366, DOI 10.1002/wps.20260
   Doehner W, 2012, INT J CARDIOL, V162, P20, DOI 10.1016/j.ijcard.2011.09.039
   Dormandy JA, 2009, ATHEROSCLEROSIS, V202, P272, DOI 10.1016/j.atherosclerosis.2008.03.002
   Dormandy JA, 2005, LANCET, V366, P1279, DOI 10.1016/S0140-6736(05)67528-9
   Erdmann E, 2007, DIABETES CARE, V30, P2773, DOI 10.2337/dc07-0717
   Erdmann E, 2007, J AM COLL CARDIOL, V49, P1772, DOI 10.1016/j.jacc.2006.12.048
   García-Bueno B, 2010, INT J NEUROPSYCHOPH, V13, P1411, DOI 10.1017/S1461145710000970
   Gold PW, 2013, MOL PSYCHIATR, V18, P154, DOI 10.1038/mp.2012.167
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Hu YZ, 2015, EXP THER MED, V10, P1109, DOI 10.3892/etm.2015.2593
   Idris I, 2012, ARCH INTERN MED, V172, P1005, DOI 10.1001/archinternmed.2012.1938
   Iqbal S, 2015, NUTRITION, V31, P901, DOI 10.1016/j.nut.2014.12.014
   Jacob AN, 2007, DIABETES OBES METAB, V9, P386, DOI 10.1111/j.1463-1326.2006.00622.x
   Kapadia R, 2008, FRONT BIOSCI-LANDMRK, V13, P1813, DOI 10.2741/2802
   Kashani L, 2013, PSYCHONEUROENDOCRINO, V38, P767, DOI 10.1016/j.psyneuen.2012.08.010
   Kemp DE, 2014, CNS DRUGS, V28, P571, DOI 10.1007/s40263-014-0158-2
   Kemp DE, 2012, J AFFECT DISORDERS, V136, P1164, DOI 10.1016/j.jad.2011.06.033
   Kemp DE, 2009, AM J PSYCHIAT, V166, P619, DOI 10.1176/appi.ajp.2008.08081195
   Köhler O, 2016, CURR NEUROPHARMACOL, V14, P732, DOI 10.2174/1570159X14666151208113700
   Köhler O, 2014, JAMA PSYCHIAT, V71, P1381, DOI 10.1001/jamapsychiatry.2014.1611
   Kotake D, 2013, EUR J PHARMACOL, V707, P95, DOI 10.1016/j.ejphar.2013.03.033
   Kovacs P, 2005, BEST PRACT RES CL EN, V19, P625, DOI 10.1016/j.beem.2005.07.003
   Lecca D, 2015, NEUROSCIENCE, V302, P23, DOI 10.1016/j.neuroscience.2015.04.026
   Lin KW, 2015, PSYCHIAT RES, V230, P846, DOI 10.1016/j.psychres.2015.10.013
   Lincoff AM, 2007, JAMA-J AM MED ASSOC, V298, P1180, DOI 10.1001/jama.298.10.1180
   Lincoff AM, 2014, JAMA-J AM MED ASSOC, V311, P1515, DOI 10.1001/jama.2014.3321
   Loke YK, 2011, BRIT MED J, V342, DOI 10.1136/bmj.d1309
   LU JM, 1988, CHINESE MED J-PEKING, V101, P587
   Matthews L, 2009, ENDOCRINOLOGY, V150, P75, DOI 10.1210/en.2008-0196
   Mazzone T, 2006, JAMA-J AM MED ASSOC, V296, P2572, DOI 10.1001/jama.296.21.joc60158
   Moreno S, 2004, NEUROSCIENCE, V123, P131, DOI 10.1016/j.neuroscience.2003.08.064
   Nissen SE, 2008, JAMA-J AM MED ASSOC, V299, P1561, DOI 10.1001/jama.299.13.1561
   Domecq JP, 2015, J CLIN ENDOCR METAB, V100, P363, DOI 10.1210/jc.2014-3421
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Perlis RH, 2006, AM J PSYCHIAT, V163, P217, DOI 10.1176/appi.ajp.163.2.217
   Pershadsingh HA, 2004, J NEUROINFLAMM, V1, DOI 10.1186/1742-2094-1-3
   Rasgon NL, 2010, THESCIENTIFICWORLDJO, V10, P321, DOI 10.1100/tsw.2010.32
   Rhee SJ, 2014, PROG NEURO-PSYCHOPH, V54, P223, DOI 10.1016/j.pnpbp.2014.06.006
   Roohafza Hamidreza, 2014, Int Sch Res Notices, V2014, P697617, DOI 10.1155/2014/697617
   Rosa AO, 2008, PROG NEURO-PSYCHOPH, V32, P1549, DOI 10.1016/j.pnpbp.2008.05.020
   Rosen CJ, 2010, NEW ENGL J MED, V363, P803, DOI 10.1056/NEJMp1008233
   Sadaghiani MS, 2011, BEHAV BRAIN RES, V224, P336, DOI 10.1016/j.bbr.2011.06.011
   Sato T, 2011, NEUROBIOL AGING, V32, P1626, DOI 10.1016/j.neurobiolaging.2009.10.009
   Schernthaner G, 2013, DIABETES CARE, V36, pS155, DOI 10.2337/dcS13-2031
   Sepanjnia K, 2012, NEUROPSYCHOPHARMACOL, V37, P2093, DOI 10.1038/npp.2012.58
   Skerrett R, 2015, J BIOL CHEM, V290, P21591, DOI 10.1074/jbc.M115.652008
   Sonino N, 2002, PROG NEURO-PSYCHOPH, V26, P1011, DOI 10.1016/S0278-5846(02)00252-X
   Tontonoz P, 2008, ANNU REV BIOCHEM, V77, P289, DOI 10.1146/annurev.biochem.77.061307.091829
   Trivedi MH, 2004, PSYCHOL MED, V34, P73, DOI 10.1017/S0033291703001107
   van Wijk JPH, 2003, ARTERIOSCL THROM VAS, V23, P1744, DOI 10.1161/01.ATV.0000090521.25968.4D
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Wilcox R, 2007, STROKE, V38, P865, DOI 10.1161/01.STR.0000257974.06317.49
   Wu JS, 2016, MOL NEUROBIOL, V53, P3626, DOI 10.1007/s12035-015-9294-z
   Zeinoddini A, 2015, DEPRESS ANXIETY, V32, P167, DOI 10.1002/da.22340
   Zhu ZN, 2014, BONE, V68, P115, DOI 10.1016/j.bone.2014.08.010
NR 62
TC 77
Z9 81
U1 0
U2 16
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0176-3679
EI 1439-0795
J9 PHARMACOPSYCHIATRY
JI Pharmacopsychiatry
PD MAR
PY 2017
VL 50
IS 2
BP 49
EP 55
DI 10.1055/s-0042-120120
PG 7
WC Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy; Psychiatry
GA ER3JR
UT WOS:000398693600001
PM 27978584
DA 2025-06-11
ER

PT J
AU Gasparro, R
   Gambino, G
   Duca, G
   Di Majo, D
   Di Liberto, V
   Tinnirello, V
   Urone, G
   Ricciardi, N
   Frinchi, M
   Ganji, NR
   Vergilio, G
   Zummo, FP
   Rappa, F
   Fontana, S
   Conigliaro, A
   Sardo, P
   Ferraro, G
   Alessandro, R
   Raimondo, S
AF Gasparro, Roberta
   Gambino, Giuditta
   Duca, Giulia
   Di Majo, Danila
   Di Liberto, Valentina
   Tinnirello, Vincenza
   Urone, Giulia
   Ricciardi, Nicolo
   Frinchi, Monica
   Ganji, Nima Rabienezhad
   Vergilio, Giuseppe
   Zummo, Francesco Paolo
   Rappa, Francesca
   Fontana, Simona
   Conigliaro, Alice
   Sardo, Pierangelo
   Ferraro, Giuseppe
   Alessandro, Riccardo
   Raimondo, Stefania
TI Protective effects of lemon nanovesicles: evidence of the Nrf2/HO-1
   pathway contribution from in vitro hepatocytes and in vivo high-fat
   diet-fed rats
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Lemon-derived nanovesicles; Oxidative stress; Liver; High-fat diet fed
   rats; Metabolic syndrome
ID OXIDATIVE STRESS; LIPID-PEROXIDATION; ANTIOXIDANT; PLASMA; NRF2;
   ACTIVATION
AB The cross-talk between plant-derived nanovesicles (PDNVs) and mammalian cells has been explored by several investigations, underlining the capability of these natural nanovesicles to regulate several molecular pathways. Additionally, PDNVs possess biological proprieties that make them applicable against pathological conditions, such as hepatic diseases. In this study we explored the antioxidant properties of lemon-derived nanovesicles, isolated at laboratory (LNVs) and industrial scale (iLNVs) in human healthy hepatocytes (THLE-2) and in metabolic syndrome induced by a high-fat diet (HFD) in the rat. Our findings demonstrate that in THLE-2 cells, LNVs and iLNVs decrease ROS production and upregulate the expression of antioxidant mediators, Nrf2 and HO1. Furthermore, the in vivo assessment reveals that the oral administration of iLNVs improves glucose tolerance and lipid dysmetabolism, ameliorates biometric parameters and systemic redox homeostasis, and upregulates Nrf2/HO-1 signaling in HFD rat liver. Consequently, we believe LNVs/iLNVs might be a promising approach for managing hepatic and dysmetabolic disorders.
C1 [Gasparro, Roberta; Duca, Giulia; Tinnirello, Vincenza; Ganji, Nima Rabienezhad; Fontana, Simona; Conigliaro, Alice; Alessandro, Riccardo; Raimondo, Stefania] Univ Palermo, Dept Biomed Nurosci & Adv Diagnost Bi N D, Sect Biol & Genet, I-90133 Palermo, Italy.
   [Gambino, Giuditta; Di Majo, Danila; Di Liberto, Valentina; Urone, Giulia; Ricciardi, Nicolo; Frinchi, Monica; Sardo, Pierangelo; Ferraro, Giuseppe] Univ Palermo, Dept Biomed Nurosci & Adv Diagnost Bi N D, Sect Human Physiol, I-90134 Palermo, Italy.
   [Vergilio, Giuseppe; Zummo, Francesco Paolo; Rappa, Francesca] Univ Palermo, Inst Human Anat & Histol, Dept Biomed Neurosci & Adv Diagnost BIND, I-90127 Palermo, Italy.
   [Rappa, Francesca] Natl Res Council Italy CNR, Inst Translat Pharmacol, I-90146 Palermo, Italy.
   [Conigliaro, Alice] Univ Palermo, ATeN Adv Technol Network Ctr, Viale Sci, I-90128 Palermo, Italy.
   [Conigliaro, Alice; Alessandro, Riccardo; Raimondo, Stefania] Univ Palermo, Navhetec Srl, Palermo, Italy.
   [Alessandro, Riccardo] Natl Res Council CNR, Inst Biomed Res & Innovat IRIB, I-90146 Palermo, Italy.
C3 University of Palermo; University of Palermo; University of Palermo;
   Consiglio Nazionale delle Ricerche (CNR); Istituto di Farmacologia
   Traslazionale (IFT-CNR); University of Palermo; University of Palermo;
   Consiglio Nazionale delle Ricerche (CNR); Istituto Ricerca l'Innovazione
   Biomedica (IRIB-CNR)
RP Raimondo, S (corresponding author), Univ Palermo, Dept Biomed Nurosci & Adv Diagnost Bi N D, Sect Biol & Genet, I-90133 Palermo, Italy.
EM stefania.raimondo@unipa.it
RI Di+Liberto, Valentina/ACL-0264-2022; Di Majo, Danila/A-9078-2015;
   Francesca, Rappa/ADW-8431-2022; Ganji, Nima/ADX-0319-2022; Zummo,
   Francesco Paolo/HME-2405-2023; Tinnirello, Vincenza/MBG-9139-2025;
   Conigliaro, Alice/ACW-5549-2022; Fontana, Simona/AAI-9072-2020
OI Frinchi, Monica/0000-0002-1061-5725; Rabie Nezhad Ganji,
   Nima/0000-0001-9408-3721; Tinnirello, Vincenza/0009-0001-0715-370X;
   Gambino, Giuditta/0000-0001-8155-2808
FU University of Palermo [1105/2023]
FX This work was fund by a grant from the University of Palermo (Incentivi
   ad attivita' di ricerca interdisciplinare, numero repertorio: 1105/2023;
   principal investigator Stefania Raimondo. Collaborators: Giuditta
   Gambino, Riccardo Alessandro, Giuseppe Ferraro) and in part by FFR 2023
   from the University of Palermo to Valentina Di Liberto. R. G., G.D. and
   V.T. are PhD students in "Biomedicina, Neuroscienze e Diagnostica
   Avanzata" at the University of Palermo.
CR Alcaraz MJ, 2020, FREE RADICAL BIO MED, V157, P83, DOI 10.1016/j.freeradbiomed.2019.12.007
   Asrani SK, 2019, J HEPATOL, V70, P151, DOI 10.1016/j.jhep.2018.09.014
   Beltowski J, 2000, J PHYSIOL PHARMACOL, V51, P883
   Berger E, 2020, MOL THER-METH CLIN D, V18, P880, DOI 10.1016/j.omtm.2020.08.009
   Biswas S, 2006, BIOCHEM PHARMACOL, V71, P551, DOI 10.1016/j.bcp.2005.10.044
   Bovi APD, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.595371
   Bulua AC, 2011, J EXP MED, V208, P519, DOI 10.1084/jem.20102049
   Chen L, 2022, CRIT REV FOOD SCI, V62, P7730, DOI 10.1080/10408398.2021.1917508
   Chorley BN, 2012, NUCLEIC ACIDS RES, V40, P7416, DOI 10.1093/nar/gks409
   COMPORTI M, 1989, CHEM-BIOL INTERACT, V72, P1, DOI 10.1016/0009-2797(89)90016-1
   Deng ZB, 2017, MOL THER, V25, P1641, DOI 10.1016/j.ymthe.2017.01.025
   Di Majo D, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12010089
   Dodson M, 2022, DIABETES, V71, P2463, DOI 10.2337/db22-0623
   Dong DD, 2022, FASEB J, V36, DOI 10.1096/fj.202101567R
   Elmarakby AA, 2010, CLIN SCI, V118, P291, DOI 10.1042/CS20090395
   Feng JJ, 2023, ADV MATER, V35, DOI 10.1002/adma.202207826
   Feng TL, 2024, INTERD MED, V2, DOI 10.1002/INMD.20230029
   FREI B, 1986, BIOCHEMISTRY-US, V25, P4438, DOI 10.1021/bi00363a040
   Gambino G, 2024, J FUNCT FOODS, V112, DOI 10.1016/j.jff.2023.105964
   Gambino G, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12051121
   Gluschko A, 2018, CELL HOST MICROBE, V23, P324, DOI 10.1016/j.chom.2018.01.018
   Halilovic A, 2016, ANTIOXID REDOX SIGN, V24, P1072, DOI 10.1089/ars.2015.6532
   Herb M, 2019, SCI SIGNAL, V12, DOI 10.1126/scisignal.aar5926
   Herrera G, 2023, NEUROPHARMACOLOGY, V239, DOI 10.1016/j.neuropharm.2023.109688
   Hirotsu Y, 2012, NUCLEIC ACIDS RES, V40, P10228, DOI 10.1093/nar/gks827
   Hobeika C, 2020, J VISC SURG, V157, P231, DOI 10.1016/j.jviscsurg.2019.11.004
   Huang WC, 2022, NUTR METAB, V19, DOI 10.1186/s12986-022-00644-w
   Hussain A, 2021, MOLECULES, V26, DOI 10.3390/molecules26020302
   Hwang JH, 2023, J CONTROL RELEASE, V355, P184, DOI 10.1016/j.jconrel.2023.01.071
   Itoh K, 1999, GENE DEV, V13, P76, DOI 10.1101/gad.13.1.76
   Kim DK, 2021, PHARMACEUTICS, V13, DOI 10.3390/pharmaceutics13081203
   Kim IH, 2015, CURR OPIN GASTROEN, V31, P184, DOI 10.1097/MOG.0000000000000176
   Kim MK, 2021, TISSUE ENG REGEN MED, V18, P561, DOI 10.1007/s13770-021-00367-8
   Koek GH, 2011, CLIN CHIM ACTA, V412, P1297, DOI 10.1016/j.cca.2011.04.013
   Kumar M., 2021, Journal of Scientific Research, V65, P57, DOI [DOI 10.37398/JSR.2021.650308, 10.37398/jsr.2021.650308]
   Lasker S, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-56538-0
   Lee BH, 2023, FOOD FUNCT, V14, P8942, DOI [10.1039/d3fo01608k, 10.1039/D3FO01608K]
   Lee S, 2017, FREE RADICAL RES, V51, P179, DOI 10.1080/10715762.2017.1291939
   Liu JF, 2023, PHYTOMEDICINE, V112, DOI 10.1016/j.phymed.2023.154679
   Liu NJ, 2020, MOL PLANT, V13, P1523, DOI 10.1016/j.molp.2020.07.016
   Liu XN, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/7161592
   Loor G, 2010, FREE RADICAL BIO MED, V49, P1925, DOI 10.1016/j.freeradbiomed.2010.09.021
   Manjunatha H, 2007, CAN J PHYSIOL PHARM, V85, P588, DOI 10.1139/Y07-044
   Mansouri A, 2018, GASTROENTEROLOGY, V155, P629, DOI 10.1053/j.gastro.2018.06.083
   Meineri G, 2017, J APPL ANIM RES, V45, P315, DOI 10.1080/09712119.2016.1190734
   Mu JY, 2014, MOL NUTR FOOD RES, V58, P1561, DOI 10.1002/mnfr.201300729
   Muriel P, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/9037051
   Nanizawa E, 2022, NUTRITION, V101, DOI 10.1016/j.nut.2022.111710
   Nohl H, 2003, BIOCHEM SOC T, V31, P1308
   Ortenzi VH, 2024, APPL PHYSIOL NUTR ME, V49, P1083, DOI [10.1139/apnm-2023-04571083, 10.1139/apnm-2023-0457]
   Pinedo M, 2021, J EXTRACELL VESICLES, V10, DOI 10.1002/jev2.12048
   Raimondo S, 2022, J CELL MOL MED, V26, P4195, DOI 10.1111/jcmm.17404
   Raimondo S, 2015, ONCOTARGET, V6, P19514, DOI 10.18632/oncotarget.4004
   Rodríguez-Correa E, 2020, NUTR DIABETES, V10, DOI 10.1038/s41387-020-0127-4
   Rojkind M, 2002, CELL MOL LIFE SCI, V59, P1872, DOI 10.1007/PL00012511
   Rozendaal YJW, 2018, PLOS COMPUT BIOL, V14, DOI 10.1371/journal.pcbi.1006145
   Savci Y, 2021, FOOD FUNCT, V12, P5144, DOI [10.1039/d0fo02953j, 10.1039/D0FO02953J]
   Stojsavljevic S, 2014, WORLD J GASTROENTERO, V20, P18070, DOI 10.3748/wjg.v20.i48.18070
   Tinnirello V., 2024, Pharm., V174, DOI [DOI 10.1016/J.BIOPHA.2024.116514, 10.1016/j.biopha.2024.116514]
   Turell L, 2013, FREE RADICAL BIO MED, V65, P244, DOI 10.1016/j.freeradbiomed.2013.05.050
   TZENG WF, 1995, J MOL CELL CARDIOL, V27, P1999, DOI 10.1016/0022-2828(95)90021-7
   Urzi O, 2023, ISCIENCE, V26, DOI 10.1016/j.isci.2023.107041
   Wang Y, 2022, CRIT REV FOOD SCI, V62, P3833, DOI 10.1080/10408398.2020.1870035
   Wu BD, 2024, ADV SCI, V11, DOI 10.1002/advs.202307630
   Xiao J, 2018, PEERJ, V6, DOI 10.7717/peerj.5186
   Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431
   Zhao WJ, 2022, ACTA PHARMACOL SIN, V43, P645, DOI 10.1038/s41401-021-00681-w
   Zhao X, 2023, BIOMATER ADV, V154, DOI 10.1016/j.bioadv.2023.213592
   Zhou JM, 2022, FRONT CELL DEV BIOL, V10, DOI 10.3389/fcell.2022.826204
   Zhuang XY, 2015, J EXTRACELL VESICLES, V4, DOI 10.3402/jev.v4.28713
NR 70
TC 1
Z9 1
U1 7
U2 11
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD NOV
PY 2024
VL 180
AR 117532
DI 10.1016/j.biopha.2024.117532
EA OCT 2024
PG 14
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA I7O3U
UT WOS:001332111700001
PM 39383731
OA gold
DA 2025-06-11
ER

PT J
AU Zerach, G
   Shevlin, M
   Solomon, Z
AF Zerach, Gadi
   Shevlin, Mark
   Solomon, Zahava
TI Associations Between Hardiness, C-Reactive Protein, and Telomere Length
   Among Former Prisoners of War
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE PTSD; hardiness; CRP; telomere length; veterans
ID POSTTRAUMATIC-STRESS-DISORDER; REPATRIATED PRISONERS; METABOLIC
   SYNDROME; II PRISONERS; HEALTH; SENESCENCE; ADJUSTMENT; MORTALITY;
   RESPONSES; CAPTIVITY
AB Background: War captivity and posttraumatic stress disorder (PTSD) are known to be associated with several poor health outcomes of an accelerated aging process. However, the contribution of personality protective factors to this phenomenon are rarely studied. The present 24-year prospective study examined associations between psychological hardiness and three health outcomes: C-reactive protein (CRP) levels, metabolic syndrome (MetS), and telomere length (TL). Method: Eighty-eight Israeli former prisoners of war (ex-POWs) were assessed 18 (T1) and 42 (T2) years after repatriation. Data on hardiness was collected at T1 while leukocyte TL, CRP, and MetS data was collected 42 years after the war. Results: While adjusting for age, body mass index (BMI), self-rated health, depressive and PTSD symptoms at T2, higher levels of hardiness at T1 predicted decreased CRP and longer TL at T2. Conclusions: Long-term health vulnerabilities of traumatized ex-POWs are manifested in an accelerated aging process and cellular senescence. Raising awareness of the importance of protective factors such as veterans' hardiness might be associated with improving their longevity and well-being.
C1 [Zerach, Gadi] Ariel Univ, Dept Behav Sci & Psychol, IL-40700 Ariel, Israel.
   [Shevlin, Mark] Ulster Univ, Sch Psychol, Coleraine, Londonderry, North Ireland.
   [Solomon, Zahava] Tel Aviv Univ, Ctr Excellence Mass Trauma Res, Tel Aviv, Israel.
C3 Ariel University; Ulster University; Tel Aviv University
RP Zerach, G (corresponding author), Ariel Univ, Dept Behav Sci & Psychol, IL-40700 Ariel, Israel.
EM gadize@ariel.ac.il
RI Zerach, Gadi/GLU-1118-2022; Shevlin, Mark/I-3242-2017
OI Shevlin, Mark/0000-0001-6262-5223
CR American Psychiatric Association (APA), 2013, Diagnostic and Statistical Manual of Mental Disorders, V5th ed
   Amris K, 2015, PAIN MANAG, V5, P5, DOI [10.2217/PMT.14.50, 10.2217/pmt.14.50]
   Bartone P T., 2015, Military Behavioral Health, V3, P274, DOI [DOI 10.1080/21635781.2015.1085931, 10.1080/21635781.2015.1085931]
   Bartone PT, 2007, PSYCHOL REP, V101, P943, DOI 10.2466/PRO.101.3.943-944
   Bartone PT, 2016, PSYCHOL HEALTH MED, V21, P743, DOI 10.1080/13548506.2015.1120323
   Basoglu M, 2009, AM J ORTHOPSYCHIAT, V79, P135, DOI 10.1037/a0015681
   Benyamini Y, 1999, RES AGING, V21, P392, DOI 10.1177/0164027599213002
   Connolly SL, 2018, J TRAUMA STRESS, V31, P676, DOI 10.1002/jts.22325
   Derogatis L.R., 1977, SCL 90 MANUAL
   Dolbier CL, 2001, J BEHAV MED, V24, P219, DOI 10.1023/A:1010762606006
   DRORY Y, 1991, ARCH PHYS MED REHAB, V72, P326
   Edmondson D, 2013, PROG CARDIOVASC DIS, V55, P548, DOI 10.1016/j.pcad.2013.03.004
   Enders CK, 2001, STRUCT EQU MODELING, V8, P128, DOI 10.1207/S15328007SEM0801_7
   Eschleman KJ, 2010, INT J STRESS MANAGE, V17, P277, DOI 10.1037/a0020476
   Ikin JF, 2010, J AFFECT DISORDERS, V125, P279, DOI 10.1016/j.jad.2009.12.005
   Jukic M, 2019, PSYCHIAT DANUB, V31, P189, DOI 10.24869/psyd.2019.189
   Kang HK, 2006, ANN EPIDEMIOL, V16, P381, DOI 10.1016/j.annepidem.2005.03.004
   King DW, 2015, CLIN PSYCHOL SCI, V3, P861, DOI 10.1177/2167702614554448
   Krauss S. W., 2018, TRAUMATOLOGY, V25, P2016
   Lindqvist D, 2017, BRAIN BEHAV IMMUN, V59, P260, DOI 10.1016/j.bbi.2016.09.012
   Lohr JB, 2015, AM J GERIAT PSYCHIAT, V23, P709, DOI 10.1016/j.jagp.2015.04.001
   Maddi S.R., 1987, Health Promotion Evaluation, P101
   Maddi SR., 2006, J POSIT PSYCHOL, V1, P160, DOI [10.1080/17439760600619609, DOI 10.1080/17439760600619609]
   Mukaka MM, 2012, MALAWI MED J, V24, P69
   Muthen L.K., 2010, Mplus User's Guide (Version 6.0)
   Nice DS, 1996, JAMA-J AM MED ASSOC, V276, P375, DOI 10.1001/jama.276.5.375
   O'Donovan A, 2015, PSYCHONEUROENDOCRINO, V51, P557, DOI 10.1016/j.psyneuen.2014.11.010
   Rintamaki LS, 2009, J AM GERIATR SOC, V57, P2257, DOI 10.1111/j.1532-5415.2009.02608.x
   Rogowski O, 2005, CLIN CHIM ACTA, V358, P151, DOI 10.1016/j.cccn.2005.02.024
   Sandvik AM, 2020, J POLICE CRIM PSYCHO, V35, P504, DOI 10.1007/s11896-019-09323-8
   Sandvik AM, 2013, PSYCHOL HEALTH MED, V18, P705, DOI 10.1080/13548506.2013.772304
   Sattar N, 2003, CIRCULATION, V108, P414, DOI 10.1161/01.CIR.0000080897.52664.94
   Segovia F, 2015, PSYCHOL TRAUMA-US, V7, P222, DOI 10.1037/a0037902
   Shalev I, 2014, MOL PSYCHIATR, V19, P1163, DOI 10.1038/mp.2013.183
   SOLOMON Z, 1993, ISRAEL J PSYCHIAT, V30, P110
   Solomon Z, 2017, J CLIN PSYCHIAT, V78, pE1180, DOI 10.4088/JCP.16m11344
   Solomon Z, 2014, J BEHAV MED, V37, P849, DOI 10.1007/s10865-013-9544-3
   Stein JY, 2018, J AFFECT DISORDERS, V238, P129, DOI 10.1016/j.jad.2018.05.037
   Thomassen ÅG, 2018, MIL PSYCHOL, V30, P142, DOI 10.1080/08995605.2018.1425065
   Uziel O, 2007, EXP GERONTOL, V42, P971, DOI 10.1016/j.exger.2007.07.005
   WIEBE DJ, 1991, J PERS SOC PSYCHOL, V60, P89
   Wolf EJ, 2016, PSYCHOL MED, V46, P2215, DOI 10.1017/S0033291716000817
   Xue C, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0120270
   Yuan KH, 2000, SOCIOL METHODOL, V30, P165, DOI 10.1111/0081-1750.00078
   Zerach G, 2017, J AFFECT DISORDERS, V218, P176, DOI 10.1016/j.jad.2017.04.025
NR 45
TC 4
Z9 6
U1 0
U2 9
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD NOV
PY 2020
VL 39
IS 11
BP 1007
EP 1012
DI 10.1037/hea0001030
PG 6
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA OH2EX
UT WOS:000582383700007
PM 32969697
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Paltoglou, G
   Raftopoulou, C
   Nicolaides, NC
   Genitsaridi, SM
   Karampatsou, SI
   Papadopoulou, M
   Kassari, P
   Charmandari, E
AF Paltoglou, George
   Raftopoulou, Christina
   Nicolaides, Nicolas C.
   Genitsaridi, Sofia M.
   Karampatsou, Sofia I.
   Papadopoulou, Marina
   Kassari, Penio
   Charmandari, Evangelia
TI A Comprehensive, Multidisciplinary, Personalized, Lifestyle Intervention
   Program Is Associated with Increased Leukocyte Telomere Length in
   Children and Adolescents with Overweight and Obesity
SO NUTRIENTS
LA English
DT Article
DE overweight; obesity; leukocyte telomere length; childhood; adolescence
ID TO-HEIGHT RATIO; INSULIN-RESISTANCE; CARDIOMETABOLIC RISK; OXIDATIVE
   STRESS; PULSE PRESSURE; INFLAMMATION; INDEX; MORTALITY; PRESCHOOL;
   ACCURACY
AB Leucocyte telomere length (LTL) is a robust marker of biological aging and is associated with obesity and cardiometabolic risk factors in childhood and adolescence. We investigated the effect of a structured, comprehensive, multidisciplinary, personalized, lifestyle intervention program of healthy diet and physical exercise on LTL in 508 children and adolescents (239 males, 269 females; 282 prepubertal, 226 pubertal), aged 10.14 +/- 0.13 years. Participants were classified as obese (n = 267, 52.6%), overweight (n = 174, 34.2%), or of normal BMI (n = 67, 13.2%) according to the International Obesity Task Force (IOTF) cutoff points and were studied prospectively for one year. We demonstrated that LTL increased significantly after 1 year of the lifestyle interventions, irrespective of gender, pubertal status, or body mass index (BMI). Waist circumference was the best negative predictor of LTL at initial assessment. The implementation of the lifestyle interventions also resulted in a significant improvement in clinical (BMI, BMI z-score and waist to height ratio) and body composition indices of obesity, inflammatory markers, hepatic enzymes, glycated hemoglobin (HbA1C), quantitative insulin sensitivity check index (QUICKI), and lipid profile in all participants. These findings indicate that the increased LTL may be associated with a more favorable metabolic profile and decreased morbidity later in life.
C1 [Paltoglou, George; Nicolaides, Nicolas C.; Genitsaridi, Sofia M.; Karampatsou, Sofia I.; Papadopoulou, Marina; Kassari, Penio; Charmandari, Evangelia] Natl & Kapodistrian Univ, Aghia Sophia Childrens Hosp, Athens Med Sch, Dept Pediat 1,Div Endocrinol Metab & Diabet, Athens 11527, Greece.
   [Raftopoulou, Christina; Charmandari, Evangelia] Acad Athens, Biomed Res Fdn, Ctr Clin Expt Surg & Translat Res, Div Endocrinol & Metab, Athens 11527, Greece.
C3 National & Kapodistrian University of Athens; The Aghia Sophia
   Children's Hospital; Academy of Athens
RP Charmandari, E (corresponding author), Natl & Kapodistrian Univ, Aghia Sophia Childrens Hosp, Athens Med Sch, Dept Pediat 1,Div Endocrinol Metab & Diabet, Athens 11527, Greece.; Charmandari, E (corresponding author), Acad Athens, Biomed Res Fdn, Ctr Clin Expt Surg & Translat Res, Div Endocrinol & Metab, Athens 11527, Greece.
EM gpaltoglou@gmail.com; xraftopoulou@yahoo.gr; nicolaidesnc@gmail.com;
   sgenitsaridi@gmail.com; karampatsousi@gmail.com;
   marinageorpap@gmail.com; peniokassari@gmail.com;
   evangelia.charmandari@googlemail.com
RI Charmandari, Evangelia/AAF-2038-2019; Paltoglou, George/B-6944-2019
OI Charmandari, Evangelia/0000-0002-0851-6998; Paltoglou,
   George/0000-0003-4300-7061; Raftopoulou, Christina/0000-0002-5132-2822;
   Kassari, Penio/0000-0003-2464-1825
FU European Regional Development Fund of the European Union; Greek national
   funds through the Operational Program Competitiveness, Entrepreneurship
   and Innovation [T1EDK-01386, MIS: 5030543]
FX This research was cofinanced by the European Regional Development Fund
   of the European Union and Greek national funds through the Operational
   Program Competitiveness, Entrepreneurship and Innovation, under the call
   RESEARCH-CREATE-INNOVATE (project code: T1EDK-01386, MIS: 5030543,
   Acronym: PEDOBESITY).
CR Afshin A, 2017, NEW ENGL J MED, V377, P13, DOI 10.1056/NEJMoa1614362
   Al-Attas OS, 2010, ACTA PAEDIATR, V99, P896, DOI 10.1111/j.1651-2227.2010.01720.x
   [Anonymous], 2015, LANCET, DOI DOI 10.1016/S0140-6736(14)61746-3
   Ashwell M, 2012, OBES REV, V13, P275, DOI 10.1111/j.1467-789X.2011.00952.x
   Aviv A, 2009, AM J EPIDEMIOL, V169, P323, DOI 10.1093/aje/kwn338
   Bacopoulou F, 2015, BMC PEDIATR, V15, DOI 10.1186/s12887-015-0366-z
   Baxter SD, 2006, NUTR RES, V26, P241, DOI 10.1016/j.nutres.2006.05.005
   Benetos A, 2001, HYPERTENSION, V37, P381, DOI 10.1161/01.HYP.37.2.381
   Buxton JL, 2011, J CLIN ENDOCR METAB, V96, P1500, DOI 10.1210/jc.2010-2924
   Carulli L, 2016, MOL GENET METAB, V118, P138, DOI 10.1016/j.ymgme.2016.04.003
   Cawthon RM, 2009, NUCLEIC ACIDS RES, V37, DOI 10.1093/nar/gkn1027
   Cawthon RM, 2003, LANCET, V361, P393, DOI 10.1016/S0140-6736(03)12384-7
   Chiotis D., 2004, Ann. Clin. Pediatr. Univ. Atheniensis, V51, P139
   Chung IH, 2016, YONSEI MED J, V57, P658, DOI 10.3349/ymj.2016.57.3.658
   Cole TJ, 2000, BMJ-BRIT MED J, V320, P1240, DOI 10.1136/bmj.320.7244.1240
   Conboy IM, 2005, NATURE, V433, P760, DOI 10.1038/nature03260
   Conway JM, 2004, J AM DIET ASSOC, V104, P595, DOI 10.1016/j.jada.2004.01.007
   Duarte LC, 2014, AGE, V36, DOI 10.1007/s11357-014-9731-3
   Epel E, 2012, CANCER PREV RES, V5, P1163, DOI 10.1158/1940-6207.CAPR-12-0370
   Friedemann C, 2012, BMJ-BRIT MED J, V345, DOI 10.1136/bmj.e4759
   García-Calzón S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0089828
   Gems D, 2014, AGING-US, V6, P84, DOI 10.18632/aging.100640
   Genitsaridi SM, 2020, HORM RES PAEDIAT, V93, P94, DOI 10.1159/000507760
   Groop PH, 2005, NAT CLIN PRACT ENDOC, V1, P100, DOI 10.1038/ncpendmet0046
   Haycock PC, 2014, BMJ-BRIT MED J, V349, DOI 10.1136/bmj.g4227
   Jeanclos E, 2000, HYPERTENSION, V36, P195, DOI 10.1161/01.HYP.36.2.195
   Kassari P, 2018, EUR J CLIN INVEST, V48, DOI 10.1111/eci.12887
   Kjaer TW, 2018, CLIN OBES, V8, P88, DOI 10.1111/cob.12233
   Kumanyika S, 2020, NEW ENGL J MED, V383, P2197, DOI 10.1056/NEJMp2029646
   Lam BCC, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0122985
   Lamprokostopoulou A, 2019, EUR J CLIN INVEST, V49, DOI 10.1111/eci.13178
   López-Otín C, 2013, CELL, V153, P1194, DOI 10.1016/j.cell.2013.05.039
   Lu WS, 2013, EXP CELL RES, V319, P133, DOI 10.1016/j.yexcr.2012.09.005
   Maffeis C, 2008, J PEDIATR-US, V152, P207, DOI 10.1016/j.jpeds.2007.09.021
   Martin ASG, 2006, AM J CLIN NUTR, V83, p461S, DOI 10.1093/ajcn/83.2.461s
   McGrath M, 2007, CANCER EPIDEM BIOMAR, V16, P815, DOI 10.1158/1055-9965.EPI-06-0961
   Nordfjäll K, 2008, OBESITY, V16, P2682, DOI 10.1038/oby.2008.413
   Okuda K, 2002, PEDIATR RES, V52, P377, DOI 10.1203/01.PDR.0000022341.72856.72
   Paltoglou G, 2019, ENDOCRINE, V66, P370, DOI 10.1007/s12020-019-02037-1
   Paltoglou G, 2017, ENDOCRINE, V55, P925, DOI 10.1007/s12020-017-1227-3
   Reinehr T, 2010, MOL CELL ENDOCRINOL, V316, P165, DOI 10.1016/j.mce.2009.06.005
   Révész D, 2014, J CLIN ENDOCR METAB, V99, P4607, DOI 10.1210/jc.2014-1851
   Ridker PM, 2000, NEW ENGL J MED, V342, P836, DOI 10.1056/NEJM200003233421202
   Salpea KD, 2010, ATHEROSCLEROSIS, V209, P42, DOI 10.1016/j.atherosclerosis.2009.09.070
   Song X, 2015, NUTR METAB CARDIOVAS, V25, P295, DOI 10.1016/j.numecd.2014.09.004
   Speliotes EK, 2010, HEPATOLOGY, V51, P1979, DOI 10.1002/hep.23593
   Sun Q, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038374
   Tragomalou A, 2020, NUTRIENTS, V12, DOI 10.3390/nu12092858
   Tragomalou A, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051380
   Valdes AM, 2007, OSTEOPOROSIS INT, V18, P1203, DOI 10.1007/s00198-007-0357-5
   Van Horn L, 2010, J AM DIET ASSOC, V110, P1638, DOI 10.1016/j.jada.2010.08.018
   Wojcicki JM, 2018, CHILD OBES, V14, P149, DOI 10.1089/chi.2017.0159
   Yajnik CS, 2015, DIABETOLOGIA, V58, P1626, DOI 10.1007/s00125-015-3602-z
   Zannolli R, 2008, ACTA PAEDIATR, V97, P952, DOI 10.1111/j.1651-2227.2008.00783.x
   Zhao ZR, 2014, J CELL PHYSIOL, V229, P1323, DOI 10.1002/jcp.24537
   Zhu HD, 2011, J PEDIATR-US, V158, P215, DOI 10.1016/j.jpeds.2010.08.007
NR 56
TC 13
Z9 14
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2021
VL 13
IS 8
AR 2682
DI 10.3390/nu13082682
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA UH5QY
UT WOS:000689986400001
PM 34444842
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sallam, HS
   Tuvdendorj, DR
   Jialal, I
   Chandalia, M
   Abate, N
AF Sallam, Hanaa S.
   Tuvdendorj, Demidmaa R.
   Jialal, Ishwarlal
   Chandalia, Manisha
   Abate, Nicola
TI Therapeutic lifestyle change intervention improved metabolic syndrome
   criteria and is complementary to amlodipine/atorvastatin
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Article
DE Amlodipine/atorvastatin; Therapeutic lifestyle; Ox-LDL; Oxidative
   stress; Metabolic syndrome
ID OXIDATIVE STRESS; ADIPOSE-TISSUE; BLOOD-PRESSURE; INSULIN SENSITIVITY;
   CARDIOVASCULAR RISK; WEIGHT-LOSS; OBESE; EXERCISE; ADULTS; CHOLESTEROL
AB Aims: To examine whether addition of amlodipine (5 mg)/atorvastatin (10 mg) A/A to Therapeutic Lifestyle change intervention (TLC) would beneficially modulate Metabolic Syndrome (MetS) and oxidized low-density lipoprotein (Ox-LDL) levels.
   Methods: Patients with MetS (n = 53) were randomized to TLC + placebo or TLC + A/A for 12 months. Anthropometric measurements, blood pressure (BP), lipid profile, plasma Ox-LDL, and area under the curve of free fatty acid (AUC(FFA)) during oral glucose tolerance test, a marker of adipose tissue health, were assessed before and after the intervention.
   Results: Twenty-six patients completed the study with an overall improvement of MetS (p = 0.02). TLC + placebo was beneficial in reversing MetS comparable to TLC + A/A (54% vs. 39%; p = 0.08). Both treatments decreased systolic BP (p <= 0.01). TLC + A/A also decreased diastolic BP and triglyceride levels. The changes in Ox-LDL levels directly correlated with changes in weight in the TLC-placebo group (r = 0.64; p = 0.04). AUC(FFA) determined the loss of fat mass (r = 0.472, p = 0.03).
   Conclusions: 1) Addition of A/A has the advantage of improving the lipid profile and BP; but TLC alone was comparable to TLC + A/A in improving MetS: 2) weight change determines the TLC-associated change in Ox-LDL levels; and 3) AT metabolic health is a significant predictor of TLC-associated loss of body fat mass. (C) 2019 Elsevier Inc. All rights reserved.
C1 [Sallam, Hanaa S.; Tuvdendorj, Demidmaa R.; Abate, Nicola] Univ Texas Med Branch, Dept Internal Med, Galveston, TX 77555 USA.
   [Chandalia, Manisha; Abate, Nicola] Bay Area Metab Hlth, Baytown, TX USA.
   [Jialal, Ishwarlal] Calif North State Univ, Coll Med, Elk Grove, CA USA.
   [Sallam, Hanaa S.] Suez Canal Univ, Fac Med, Dept Physiol, Ismailia, Egypt.
C3 University of Texas System; University of Texas Medical Branch
   Galveston; Egyptian Knowledge Bank (EKB); Suez Canal University
RP Abate, N (corresponding author), Univ Texas Med Branch, Dept Internal Med, Div Endocrinol, Galveston, TX 77555 USA.
EM nicola.abate13@gmail.com
RI Sallam, Hanaa/ABD-7361-2020; Tuvdendorj, Demidmaa/AAC-4196-2019
FU Pfizer Inc.; Clinical and Translational Science Award from the National
   Center for Advancing Translational Sciences, National Institutes of
   Health [UL1 TR001439]; Mentored Career Development (KL2) Award from the
   National Center for Advancing Translational Sciences, National
   Institutes of Health [KL2TR001441]; Institute for Translational Sciences
   at the University of Texas Medical Branch
FX This study was funded by Pfizer Inc., and conducted with the support of
   the Institute for Translational Sciences at the University ofTexas
   Medical Branch, supported in part by a Clinical and Translational
   Science Award (UL1 TR001439) and Mentored Career Development (KL2) Award
   (KL2TR001441) from the National Center for Advancing Translational
   Sciences, National Institutes of Health. The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the National Institutes of Health.
CR ABATE N, 1995, J CLIN INVEST, V96, P88, DOI 10.1172/JCI118083
   Abate N, 2002, J CLIN ENDOCR METAB, V87, P4522, DOI 10.1210/jc.2002-020567
   Al-Mahmood AK, 2007, J ATHEROSCLER THROMB, V14, P122, DOI 10.5551/jat.14.122
   Altieri MS, 2015, SURG OBES RELAT DIS, V11, P431, DOI 10.1016/j.soard.2014.09.019
   Andersen CJ, 2013, REV ENDOCR METAB DIS, V14, P241, DOI 10.1007/s11154-013-9251-y
   Andreassi MG, 2009, MUTAT RES-FUND MOL M, V667, P35, DOI 10.1016/j.mrfmmm.2008.10.018
   Aranda JF, 2013, FREE RADICAL BIO MED, V64, P31, DOI 10.1016/j.freeradbiomed.2013.07.014
   Armstrong C, 2014, AM FAM PHYSICIAN, V90, P503
   Bachar A, 2014, DIABETES RES CLIN PR, V106, P511, DOI 10.1016/j.diabres.2014.09.055
   Bassi N, 2014, AM J MED, V127, DOI 10.1016/j.amjmed.2014.06.035
   Beavers Kristen M, 2011, Front Biosci (Schol Ed), V3, P168
   Beltrán-Sánchez H, 2013, J AM COLL CARDIOL, V62, P697, DOI 10.1016/j.jacc.2013.05.064
   Brown T, 2009, OBES REV, V10, P627, DOI 10.1111/j.1467-789X.2009.00641.x
   Brozek J., 1961, Tech Meas Body Compos., P223
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   de Glisezinski I, 2003, AM J PHYSIOL-ENDOC M, V285, pE984, DOI 10.1152/ajpendo.00152.2003
   Dimitriadis G, 2007, DIABETES CARE, V30, P3128, DOI 10.2337/dc07-0699
   Feldman RD, 2012, CURR MED RES OPIN, V28, P1421, DOI 10.1185/03007995.2012.713339
   Ferdinand KC, 2009, J CLIN HYPERTENS, V11, P585, DOI 10.1111/j.1751-7176.2009.00062.x
   Foster GD, 2001, ARCH INTERN MED, V161, P2133, DOI 10.1001/archinte.161.17.2133
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Hickner RC, 2012, OBESITY, V20, P1174, DOI 10.1038/oby.2011.91
   Jialal I, 2012, J CLIN ENDOCR METAB, V97, pE1844, DOI 10.1210/jc.2012-2498
   Jocken JWE, 2008, DIABETOLOGIA, V51, P320, DOI 10.1007/s00125-007-0866-y
   Marwick TH, 2009, CIRCULATION, V119, P3244, DOI 10.1161/CIRCULATIONAHA.109.192521
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Oh EG, 2013, BIOL RES NURS, V15, P48, DOI 10.1177/1099800411416637
   Pennathur S, 2017, J DIABETES COMPLICAT, V31, P1437, DOI 10.1016/j.jdiacomp.2017.03.008
   Perlstein TS, 2012, CLIN SCI, V122, P193, DOI 10.1042/CS20110284
   Singh U, 2008, AM J CARDIOL, V102, P321, DOI 10.1016/j.amjcard.2008.03.057
   Souza DR, 2015, SCAND J MED SCI SPOR, V25, P53, DOI 10.1111/sms.12152
   Svetkey LP, 2012, OBESITY, V20, P1820, DOI 10.1038/oby.2011.88
   Tanaka M, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-56
   Thomas TR, 2010, J APPL PHYSIOL, V109, P3, DOI 10.1152/japplphysiol.01361.2009
   Tuvdendorj D, 2013, AM J PHYSIOL-ENDOC M, V305, pE999, DOI 10.1152/ajpendo.00194.2013
   Villareal DT, 2006, AM J CLIN NUTR, V84, P1317, DOI 10.1093/ajcn/84.6.1317
   Yamaoka K, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-138
NR 37
TC 2
Z9 2
U1 1
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD MAR
PY 2020
VL 34
IS 3
AR 107480
DI 10.1016/j.jdiacomp.2019.107480
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA KO3KH
UT WOS:000515446800011
PM 31902653
DA 2025-06-11
ER

PT J
AU Kaya, A
   Koçyigit, C
   Çatli, G
   Özkan, EB
   Dündar, BN
AF Kaya, Abdurrahman
   Kocyigit, Cemil
   Catli, Gonul
   Ozkan, Elif Busra
   Dundar, Bumin Nuri
TI The Relationship Between Glycemic Variability and Inflammatory Markers
   in Obese Children with Insulin Resistance and Metabolic Syndrome
SO JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
LA English
DT Article
DE Glycemic variability; metabolic syndrome; interleukin-6; adiponectin
ID ENDOTHELIAL FUNCTION; OXIDATIVE STRESS; TURKISH CHILDREN; ADOLESCENTS;
   ADIPONECTIN; GLUCOSE
AB Objective: Increased glycemic variability (GV) is associated with increased oxidative stress, vascular complications, and mortality in metabolic syndrome (MS) and diabetes mellitus patients. To investigate the relationship between GV and inflammatory parameters in obese children with insulin resistance (IR) and to elucidate their effects on the development of MS.
   Methods: Fifty obese adolescents with IR were included in the study. All patients underwent anthropometric measurements, body fat analysis, and continuous glucose monitoring system (CGMS) for 24 hours. Serum lipids, adiponectin, and interleukin-6 (IL-6) levels were measured. GV coefficient (GVC) was calculated using the standard deviation and the average glucose value obtained by CGMS. IR was diagnosed according to the results of oral glucose tolerance test (OGTT). MS was diagnosed according to the modified World Health Organization and the International Diabetes Federation criteria.
   Results: Twenty-seven of the patients had MS and the remaining had only IR. Body fat mass, HbA1c, IL-6 levels, and peak insulin levels in the OGTT were significantly higher in the group with MS, but there was no difference in adiponectin levels. GVC was not different between the groups, but GVC significantly positively correlated with homeostasis model of assessment for IR, as well as with fasting, peak, and total insulin levels when all the patients were analyzed, while no significant relation was detected with adiponectin and IL-6 levels.
   Conclusion: This study suggests that GV is not different among obese adolescents with IR and MS. There seems to be a significant association between GV and IR parameters. However, other diagnostic criteria of MS (hypertension and/or dyslipidemia) or elevated IL-6 levels does not cause further increase in GV.
C1 [Kaya, Abdurrahman] Tepec Training & Res Hosp, Clin Pediat, Izmir, Turkey.
   [Kocyigit, Cemil; Catli, Gonul; Dundar, Bumin Nuri] Izmir Katip Celebi Univ, Fac Med, Dept Pediat Endocrinol, Izmir, Turkey.
   [Ozkan, Elif Busra] Izmir Katip Celebi Univ, Fac Med, Izmir, Turkey.
C3 Izmir Tepecik Training & Research Hospital; Izmir Katip Celebi
   University; Izmir Katip Celebi University
RP Dündar, BN (corresponding author), Izmir Katip Celebi Univ, Fac Med, Dept Pediat Endocrinol, Izmir, Turkey.
EM bumindundar@gmail.com
RI koçyiğit, cemil/JYP-4433-2024; Catli, Gönül/AFT-1499-2022; Dündar,
   Bumin/JVE-1747-2024
OI Dundar, Bumin N/0000-0002-7506-061X; Catli, Gonul/0000-0002-0488-6377
CR Balkau B, 1999, DIABETIC MED, V16, P442
   Bundak R, 2006, ACTA PAEDIATR, V95, P194, DOI 10.1080/08035250500334738
   Buscemi S, 2009, DIABETES, V58, pA107
   Ceriello A, 2008, DIABETES, V57, P1349, DOI 10.2337/db08-0063
   Garanty-Bogacka B, 2011, ENDOKRYNOL POL, V62, P499
   Hatipoglu N, 2008, EUR J PEDIATR, V167, P383, DOI 10.1007/s00431-007-0502-3
   Huang KC, 2004, OBES RES, V12, P119, DOI 10.1038/oby.2004.16
   Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2548, DOI 10.1210/jc.2004-0395
   Makni E, 2013, OBESITY FACTS, V6, P393, DOI 10.1159/000354574
   Mirza S, 2012, CYTOKINE, V57, P136, DOI 10.1016/j.cyto.2011.09.029
   Moses RG, 2016, DIABETES CARE, V39, P13, DOI 10.2337/dci15-0030
   Natl High Blood Pressure Educ Prog, 2004, PEDIATRICS, V114, P555
   Panagopoulou P, 2008, J PEDIATR GASTR NUTR, V47, P356, DOI 10.1097/MPG.0b013e31817fcb67
   Saisho Y, 2014, INT J MOL SCI, V15, P18381, DOI 10.3390/ijms151018381
   Valerio G, 2006, NUTR METAB CARDIOVAS, V16, P279, DOI 10.1016/j.numecd.2005.12.007
   Zimmet P, 2007, PEDIATR DIABETES, V8, P299, DOI 10.1111/j.1399-5448.2007.00271.x
NR 16
TC 19
Z9 19
U1 0
U2 5
PU GALENOS YAYINCILIK
PI FINDIKZADE
PA ERKAN MOR, MOLLA GURANI CAD 21-1, FINDIKZADE, ISTANBUL 34093, TURKEY
SN 1308-5727
EI 1308-5735
J9 J CLIN RES PEDIATR E
JI J. Clin Res. Pediatr. Endocrinol.
PD SEP
PY 2017
VL 9
IS 3
BP 202
EP 207
DI 10.4274/jcrpe.4031
PG 6
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA FG5TV
UT WOS:000410406300003
PM 28163257
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Yu, H
   Yi, XZ
   Gao, X
   Ji, J
   Liu, ZY
   Xia, GH
   Li, CA
   Zhang, XY
   Shen, XR
AF Yu, Hui
   Yi, Xiangzhou
   Gao, Xia
   Ji, Jun
   Liu, Zhongyuan
   Xia, Guanghua
   Li, Chuan
   Zhang, Xueying
   Shen, Xuanri
TI Tilapia-Head Chondroitin Sulfate Protects against Nonalcoholic Fatty
   Liver Disease via Modulating the Gut-Liver Axis in High-Fat-Diet-Fed
   C57BL/6 Mice
SO FOODS
LA English
DT Article
DE tilapia head; chondroitin sulfate; nonalcoholic fatty liver disease;
   gut-liver axis
ID METABOLIC SYNDROME; OXIDATIVE STRESS; MICROBIOTA; POLYSACCHARIDES;
   OLIGOSACCHARIDES; PRODUCTS; EXTRACT
AB We isolated and characterized tilapia-head chondroitin sulfate (TH-CS) and explored its biological activity and mechanisms of action as an oral supplement for nonalcoholic fatty liver disease (NAFLD) induced by a high-fat diet (HFD) in mice. The results showed that treatment with TH-CS for 8 weeks alleviated the development of NAFLD, as evidenced by the notable improvement in liver damage, blood lipid accumulation and insulin resistance (IR). Meanwhile, TH-CS treatment reduced the expression of proinflammatory cytokines and normalized oxidative stress. Additionally, the analysis of 16S rDNA sequencing revealed that TH-CS could restore gut microbiota balance and increase the relative abundance of short-chain fatty acid (SCFA)-producing bacteria. Furthermore, SCFAs produced by related bacteria can further improve lipid metabolism and IR by regulating lipid synthesis signals. In conclusion, TH-CS is an effective dietary supplement for the prevention of NAFLD, and may serve as a potential supplementary treatment for lipid-related metabolic syndrome.
C1 [Yu, Hui; Yi, Xiangzhou; Gao, Xia; Ji, Jun; Liu, Zhongyuan; Xia, Guanghua; Li, Chuan; Zhang, Xueying; Shen, Xuanri] Hainan Univ, Hainan Engn Res Ctr Aquat Resources Efficient Uti, Haikou 570228, Hainan, Peoples R China.
   [Yu, Hui; Yi, Xiangzhou; Gao, Xia; Ji, Jun; Liu, Zhongyuan; Xia, Guanghua; Li, Chuan; Zhang, Xueying; Shen, Xuanri] Hainan Univ, Coll Food Sci & Technol, Haikou 570228, Hainan, Peoples R China.
   [Liu, Zhongyuan; Xia, Guanghua; Li, Chuan; Zhang, Xueying; Shen, Xuanri] Dalian Polytech Univ, Collaborat Innovat Ctr Marine Food Deep Proc, Dalian 116000, Peoples R China.
C3 Hainan University; Hainan University; Dalian Polytechnic University
RP Shen, XR (corresponding author), Hainan Univ, Hainan Engn Res Ctr Aquat Resources Efficient Uti, Haikou 570228, Hainan, Peoples R China.; Shen, XR (corresponding author), Hainan Univ, Coll Food Sci & Technol, Haikou 570228, Hainan, Peoples R China.; Shen, XR (corresponding author), Dalian Polytech Univ, Collaborat Innovat Ctr Marine Food Deep Proc, Dalian 116000, Peoples R China.
EM yuhui19970607@163.com; xiangzhouyi1995@hainanu.edu.cn;
   gaoxia20202021@163.com; jijunbest@126.com; liuzhongyuan999@126.com;
   xiaguanghua@vip.163.com; lichuanbest@126.com; 994257@hainanu.edu.cn;
   xuanrishen@hainanu.edu.cn
RI Xia, Guanghua/AAN-1812-2021; Yi, Xiangzhou/GZG-3068-2022; zhang,
   xueying/JMB-7808-2023
FU National Key R&D Programs of China [2018YFD0901103]; Project of Haikou
   Ocean and Fisheries Bureau [HHCL201804]
FX This research was funded by the National Key R&D Programs of China,
   grant number 2018YFD0901103 and the Project of Haikou Ocean and
   Fisheries Bureau, grant number HHCL201804.
CR Vázquez JA, 2019, CARBOHYD POLYM, V210, P302, DOI 10.1016/j.carbpol.2019.01.075
   Bougatef H, 2019, INT J BIOL MACROMOL, V134, P405, DOI 10.1016/j.ijbiomac.2019.05.036
   Buzzetti E, 2016, METABOLISM, V65, P1038, DOI 10.1016/j.metabol.2015.12.012
   Cheng F, 2017, FOOD FUNCT, V8, P1475, DOI [10.1039/c6fo01332e, 10.1039/C6FO01332E]
   Dahlhoff C, 2014, MOL METAB, V3, P565, DOI 10.1016/j.molmet.2014.04.010
   Ding XQ, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/9734560
   Feldstein AE, 2004, HEPATOLOGY, V40, P185, DOI 10.1002/hep.20283
   Han KH, 2006, BIOSCI BIOTECH BIOCH, V70, P1432, DOI 10.1271/bbb.50670
   Heeba GH, 2015, ENVIRON TOXICOL PHAR, V40, P907, DOI 10.1016/j.etap.2015.10.003
   Khan HM, 2013, PAK VET J, V33, P471
   Kim KJ, 2012, FITOTERAPIA, V83, P1105, DOI 10.1016/j.fitote.2012.04.027
   Kindt A, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05767-4
   KOSAKAI M, 1979, ANAL BIOCHEM, V93, P295, DOI 10.1016/S0003-2697(79)80083-4
   Leung C, 2016, NAT REV GASTRO HEPAT, V13, P412, DOI 10.1038/nrgastro.2016.85
   Li DM, 2021, J AGR FOOD CHEM, V69, P6829, DOI 10.1021/acs.jafc.1c02532
   Li L, 2015, J PHARMACOL SCI, V127, P244, DOI 10.1016/j.jphs.2014.12.001
   Li S, 2018, CARBOHYD POLYM, V201, P634, DOI 10.1016/j.carbpol.2018.08.020
   Li W, 2019, CARBOHYD POLYM, V214, P303, DOI 10.1016/j.carbpol.2019.03.025
   Li WF, 2016, MOL NUTR FOOD RES, V60, P502, DOI 10.1002/mnfr.201500547
   Ma P, 2020, FOOD SCI NUTR, V8, P3212, DOI 10.1002/fsn3.1581
   Magni P, 2015, EUR J INTERN MED, V26, P82, DOI 10.1016/j.ejim.2015.01.002
   Martel-Pelletier J, 2015, MOLECULES, V20, P4277, DOI 10.3390/molecules20034277
   Medeiros LHC, 2021, BRAZ J MED BIOL RES, V54, DOI [10.1590/1414-431X2020e10730, 10.1590/1414-431x2020e10730]
   Milic S, 2014, WORLD J GASTROENTERO, V20, P9330, DOI 10.3748/wjg.v20.i28.9330
   Nakano Takuo, 2010, Recent Pat Food Nutr Agric, V2, P61, DOI 10.2174/1876142911002010061
   Novoa-Carballal R, 2017, CARBOHYD POLYM, V157, P31, DOI 10.1016/j.carbpol.2016.09.050
   Orak HH, 2012, FOOD SCI BIOTECHNOL, V21, P373, DOI 10.1007/s10068-012-0049-6
   Ormazabal V, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0762-4
   Pan JQ, 2021, J GASTROEN HEPATOL, V36, P3438, DOI 10.1111/jgh.15627
   Patel S, 2012, 3 BIOTECH, V2, P171, DOI 10.1007/s13205-012-0061-9
   Sarzanini C, 2000, J CHROMATOGR A, V884, P251, DOI 10.1016/S0021-9673(00)00252-1
   Seol BG, 2020, NUTR RES PRACT, V14, P175, DOI 10.4162/nrp.2020.14.3.175
   Shang QS, 2016, INT J BIOL MACROMOL, V89, P489, DOI 10.1016/j.ijbiomac.2016.04.091
   Sikder K, 2018, CELL PHYSIOL BIOCHEM, V48, P1317, DOI 10.1159/000492091
   Tripathi A, 2018, NAT REV GASTRO HEPAT, V15, P397, DOI 10.1038/s41575-018-0011-z
   Wang XJ, 2019, CARBOHYD POLYM, V207, P191, DOI 10.1016/j.carbpol.2018.11.086
   Wang XL, 2018, CARBOHYD POLYM, V195, P601, DOI 10.1016/j.carbpol.2018.05.003
   Wu S, 2020, INT J BIOL MACROMOL, V164, P2062, DOI 10.1016/j.ijbiomac.2020.08.010
   Yan ZG, 2015, INT J BIOL MACROMOL, V80, P573, DOI 10.1016/j.ijbiomac.2015.05.054
   Yilmaz Y, 2012, ALIMENT PHARM THER, V36, P815, DOI 10.1111/apt.12046
   Yu Y, 2018, CARBOHYD POLYM, V183, P91, DOI 10.1016/j.carbpol.2017.12.009
   Zivkovic AM, 2007, AM J CLIN NUTR, V86, P285, DOI 10.1093/ajcn/86.2.285
NR 42
TC 8
Z9 8
U1 4
U2 56
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD APR
PY 2022
VL 11
IS 7
AR 922
DI 10.3390/foods11070922
PG 19
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 0L2SN
UT WOS:000781329800001
PM 35407014
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gaspar, RS
   Trostchansky, A
   Paes, AMD
AF Gaspar, Renato Simoes
   Trostchansky, Andres
   de Andrade Paes, Antonio Marcus
TI Potential Role of Protein Disulfide Isomerase in Metabolic
   Syndrome-Derived Platelet Hyperactivity
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID VASCULAR SMOOTH-MUSCLE; TRANSIENT ISCHEMIC ATTACK; NADPH-OXIDASE 1;
   NITRIC-OXIDE; OXIDATIVE STRESS; CARDIOVASCULAR RISK; THROMBUS FORMATION;
   INSULIN-RECEPTOR; NAD(P)H OXIDASE; ACTIVATION
AB Metabolic Syndrome (MetS) has become a worldwide epidemic, alongside with a high socioeconomic cost, and its diagnostic criteria must include at least three out of the five features: visceral obesity, hypertension, dyslipidemia, insulin resistance, and high fasting glucose levels. MetS shows an increased oxidative stress associated with platelet hyperactivation, an essential component for thrombus formation and ischemic events in MetS patients. Platelet aggregation is governed by the peroxide tone and the activity of Protein Disulfide Isomerase (PDI) at the cell membrane. PDI redox active sites present active cysteine residues that can be susceptible to changes in plasma oxidative state, as observed in MetS. However, there is a lack of knowledge about the relationship between PDI and platelet hyperactivation under MetS and its metabolic features, in spite of PDI being a mediator of important pathways implicated in MetS-induced platelet hyperactivation, such as insulin resistance and nitric oxide dysfunction. Thus, the aim of this review is to analyze data available in the literature as an attempt to support a possible role for PDI in MetS-induced platelet hyperactivation.
C1 [Gaspar, Renato Simoes; de Andrade Paes, Antonio Marcus] Univ Fed Maranhao, Dept Physiol Sci, Lab Expt Physiol, Sao Luis, MA, Brazil.
   [Trostchansky, Andres] Univ Republica, Dept Bioquim, Montevideo, Uruguay.
   [Trostchansky, Andres] Univ Republica, Fac Med, Ctr Free Rad & Biomed Res, Montevideo, Uruguay.
   [Trostchansky, Andres; de Andrade Paes, Antonio Marcus] Univ Fed Maranhao, Hlth Sci Grad Program, Biol & Hlth Sci Ctr, Sao Luis, MA, Brazil.
C3 Universidade Federal do Maranhao; Universidad de la Republica, Uruguay;
   Universidad de la Republica, Uruguay; Universidade Federal do Maranhao
RP Paes, AMD (corresponding author), Univ Fed Maranhao, Dept Physiol Sci, Lab Expt Physiol, Sao Luis, MA, Brazil.; Paes, AMD (corresponding author), Univ Fed Maranhao, Hlth Sci Grad Program, Biol & Hlth Sci Ctr, Sao Luis, MA, Brazil.
EM marcuspaes@ufma.br
RI Gaspar, Renato/N-7061-2019; Trostchansky, Andres/I-5624-2019; Paes,
   Antonio Marcus de Andrade/C-7174-2013
OI Simoes Gaspar, Renato/0000-0001-6639-9470; Trostchansky,
   Andres/0000-0002-9721-7577; Paes, Antonio Marcus de
   Andrade/0000-0002-3803-9803
FU Fundacao de Amparo a Pesquisa e ao Desenvolvimento Cientifico e
   Tecnologico do Maranhao, FAPEMA [APP 0395/12, ESTAGIO 0814/13, APCINTER
   02698/14]; Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico, CNPq [485251/2012-4]; CSIC grupos I+D [536]; FAPEMA
   [PVI-05558/15]
FX The authors thank the Fundacao de Amparo a Pesquisa e ao Desenvolvimento
   Cientifico e Tecnologico do Maranhao, FAPEMA (APP 0395/12, ESTAGIO
   0814/13, APCINTER 02698/14) and Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico, CNPq (485251/2012-4). Andres Trostchansky was
   supported by CSIC grupos I+D 2014 (536) and FAPEMA (PVI-05558/15).
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Anderson RA, 2004, EUR J HEART FAIL, V6, P47, DOI 10.1016/S1388-9842(03)00038-2
   Andrews NP, 2001, J AM COLL CARDIOL, V37, P510, DOI 10.1016/S0735-1097(00)01114-1
   Anfossi G, 2008, CURR VASC PHARMACOL, V6, P313, DOI 10.2174/157016108785909760
   Audoly LP, 2000, CIRCULATION, V101, P2833, DOI 10.1161/01.CIR.101.24.2833
   Banerjee Debipriya, 2016, Int J Biomed Sci, V12, P25
   Bell SE, 2007, BIOCHEM J, V403, P283, DOI 10.1042/BJ20061146
   BLATTER LA, 1994, CELL CALCIUM, V15, P122, DOI 10.1016/0143-4160(94)90051-5
   Brown AS, 1998, CARDIOVASC RES, V40, P380, DOI 10.1016/S0008-6363(98)00182-5
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Burgess JK, 2000, J BIOL CHEM, V275, P9758, DOI 10.1074/jbc.275.13.9758
   CHEN K, 1992, BLOOD, V79, P2226
   Chiu J, 2015, SEMIN THROMB HEMOST, V41, P765, DOI 10.1055/s-0035-1564047
   Cho J, 2012, BLOOD, V120, P647, DOI 10.1182/blood-2011-08-372532
   Clempus RE, 2007, ARTERIOSCL THROM VAS, V27, P42, DOI 10.1161/01.ATV.0000251500.94478.18
   Crescente M, 2016, ARTERIOSCL THROM VAS, V36, P1164, DOI 10.1161/ATVBAHA.116.307461
   DarleyUsmar V, 1996, PHARM RES-DORDR, V13, P649, DOI 10.1023/A:1016079012214
   Davì G, 2002, JAMA-J AM MED ASSOC, V288, P2008, DOI 10.1001/jama.288.16.2008
   DEGRAAF JC, 1992, CIRCULATION, V85, P2284, DOI 10.1161/01.CIR.85.6.2284
   Delaney MK, 2016, ARTERIOSCL THROM VAS, V36, P846, DOI 10.1161/ATVBAHA.116.307308
   Drummond GR, 2014, TRENDS ENDOCRIN MET, V25, P452, DOI 10.1016/j.tem.2014.06.012
   Essex DW, 2009, ANTIOXID REDOX SIGN, V11, P1191, DOI [10.1089/ars.2008.2322, 10.1089/ARS.2008.2322]
   Essex DW, 1999, BIOCHEMISTRY-US, V38, P10398, DOI 10.1021/bi990694s
   ESSEX DW, 1995, BLOOD, V86, P2168, DOI 10.1182/blood.V86.6.2168.bloodjournal8662168
   FALCON C, 1988, BIOCHEM BIOPH RES CO, V157, P1190, DOI 10.1016/S0006-291X(88)81000-3
   Fernandes DC, 2009, ARCH BIOCHEM BIOPHYS, V484, P197, DOI 10.1016/j.abb.2009.01.022
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Freedman JE, 1997, J CLIN INVEST, V100, P350, DOI 10.1172/JCI119540
   Fuentes E, 2016, LIFE SCI, V148, P17, DOI 10.1016/j.lfs.2016.02.026
   Gambim MH, 2007, CRIT CARE, V11, DOI 10.1186/cc6133
   Go YM, 2011, FREE RADICAL BIO MED, V50, P495, DOI 10.1016/j.freeradbiomed.2010.11.029
   Griendling KK, 2006, ANTIOXID REDOX SIGN, V8, P1443, DOI 10.1089/ars.2006.8.1443
   HAJEK AS, 1979, J CLIN INVEST, V63, P1060, DOI 10.1172/JCI109375
   Heckler EJ, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0143523
   Heckler EJ, 2013, BIOCHEM J, V452, P161, DOI 10.1042/BJ20130298
   Hink U, 2001, CIRC RES, V88, pE14
   HOLMGREN A, 1979, J BIOL CHEM, V254, P9627
   Hotchkiss KA, 1996, BIOCHEMISTRY-US, V35, P9761, DOI 10.1021/bi9603938
   Janiszewski M, 2005, J BIOL CHEM, V280, P40813, DOI 10.1074/jbc.M509255200
   Janiszewski M, 2004, CRIT CARE MED, V32, P818, DOI 10.1097/01.CCM.0000114829.17746.19
   Jennings LK, 2009, THROMB HAEMOSTASIS, V102, P248, DOI 10.1160/TH09-03-0192
   Jones DP, 2010, DIABETES OBES METAB, V12, P116, DOI 10.1111/j.1463-1326.2010.01266.x
   Jones DP, 2006, ANTIOXID REDOX SIGN, V8, P1865, DOI 10.1089/ars.2006.8.1865
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kitada M, 2010, J DIABETES INVEST, V1, P77, DOI 10.1111/j.2040-1124.2010.00018.x
   Konieczynska M, 2014, THROMB HAEMOSTASIS, V111, P685, DOI 10.1160/TH13-07-0566
   Kwon HW, 2016, J GINSENG RES, V40, P76, DOI 10.1016/j.jgr.2015.05.004
   Lahav J, 2003, BLOOD, V102, P2085, DOI 10.1182/blood-2002-06-1646
   Lambeth JD, 2007, FREE RADICAL BIO MED, V43, P319, DOI 10.1016/j.freeradbiomed.2007.03.028
   Lassègue B, 2012, CIRC RES, V110, P1364, DOI 10.1161/CIRCRESAHA.111.243972
   Lassègue B, 2010, ARTERIOSCL THROM VAS, V30, P653, DOI 10.1161/ATVBAHA.108.181610
   Laurindo FRM, 2008, ANTIOXID REDOX SIGN, V10, P1101, DOI 10.1089/ars.2007.2011
   Lee MY, 2009, ARTERIOSCL THROM VAS, V29, P480, DOI 10.1161/ATVBAHA.108.181925
   Lerman A, 2005, CIRCULATION, V111, P363, DOI 10.1161/01.CIR.0000153339.27064.14
   Magwenzi S, 2015, BLOOD, V125, P2693, DOI 10.1182/blood-2014-05-574491
   Martyn KD, 2006, CELL SIGNAL, V18, P69, DOI 10.1016/j.cellsig.2005.03.023
   Masquio DCL, 2015, BRIT J NUTR, V113, P1920, DOI 10.1017/S0007114515001129
   Mathew M, 2010, CARDIOVASC DIABETOL, V9, DOI 10.1186/1475-2840-9-9
   Monteiro PF, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-5
   Paes AMD, 2011, J LEUKOCYTE BIOL, V90, P799, DOI 10.1189/jlb.0610324
   Paneni F, 2013, EUR HEART J, V34, P2436, DOI 10.1093/eurheartj/eht149
   Papaharalambus CA, 2007, TRENDS CARDIOVAS MED, V17, P48, DOI 10.1016/j.tcm.2006.11.005
   Patrono C, 2005, CURR OPIN PHARMACOL, V5, P198, DOI 10.1016/j.coph.2004.11.003
   Patrono C, 2015, J AM COLL CARDIOL, V66, P74, DOI 10.1016/j.jacc.2015.05.012
   Pescatore LA, 2012, J BIOL CHEM, V287, P29290, DOI 10.1074/jbc.M112.394551
   Pignatelli P, 2011, ARTERIOSCL THROM VAS, V31, P423, DOI 10.1161/ATVBAHA.110.217885
   Ramachandran N, 2001, P NATL ACAD SCI USA, V98, P9539, DOI 10.1073/pnas.171180998
   Raturi A, 2008, BBA-BIOMEMBRANES, V1778, P2790, DOI 10.1016/j.bbamem.2008.07.003
   Reinhardt C, 2008, J CLIN INVEST, V118, P1110, DOI 10.1172/JCI32376
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Robertson RP, 2004, DIABETES, V53, pS119, DOI 10.2337/diabetes.53.2007.S119
   Root P, 2004, BIOCHEM J, V382, P575, DOI 10.1042/BJ20040759
   Russo I, 2004, THROMB RES, V114, P265, DOI 10.1016/j.thromres.2004.06.036
   da Fonseca LJS, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/898501
   Santilli F, 2012, OBES REV, V13, P27, DOI 10.1111/j.1467-789X.2011.00930.x
   Santilli F, 2015, FREE RADICAL BIO MED, V80, P101, DOI 10.1016/j.freeradbiomed.2014.12.010
   Santos CXC, 2009, J LEUKOCYTE BIOL, V86, P989, DOI 10.1189/jlb.0608354
   Schildknecht S, 2008, FREE RADICAL BIO MED, V45, P512, DOI 10.1016/j.freeradbiomed.2008.04.042
   Schwaller M, 2003, J BIOL CHEM, V278, P7154, DOI 10.1074/jbc.M211036200
   Seno T, 2001, THROMB RES, V103, P399, DOI 10.1016/S0049-3848(01)00341-3
   Spanidis Y, 2016, EXP THER MED, V11, P895, DOI 10.3892/etm.2016.2968
   Suslova TE, 2015, FRONT PHYSIOL, V5, DOI 10.3389/fphys.2014.00501
   TOUYZ RM, 1994, J HYPERTENS, V12, P1255
   Towfighi A, 2008, CURR DIABETES REP, V8, P37, DOI 10.1007/s11892-008-0008-z
   Trostchansky A, 2007, FREE RADICAL BIO MED, V42, P1029, DOI 10.1016/j.freeradbiomed.2007.01.009
   Trovati M, 1997, DIABETES, V46, P742, DOI 10.2337/diabetes.46.5.742
   TROVATI M, 1995, DIABETES, V44, P1318, DOI 10.2337/diabetes.44.11.1318
   TROVATI M, 1988, DIABETES, V37, P780, DOI 10.2337/diabetes.37.6.780
   Tsimerman G, 2011, THROMB HAEMOSTASIS, V106, P310, DOI 10.1160/TH10-11-0712
   UDVARDY M, 1985, EXPERIENTIA, V41, P422, DOI 10.1007/BF02004539
   Uehara T, 2006, NATURE, V441, P513, DOI 10.1038/nature04782
   Van Buul JD, 2005, ANTIOXID REDOX SIGN, V7, P308, DOI 10.1089/ars.2005.7.308
   van Rooy MJ, 2015, CARDIOVASC DIABETOL, V14, DOI 10.1186/s12933-015-0249-5
   van Rooy MJ, 2015, THROMB RES, V135, P434, DOI 10.1016/j.thromres.2014.12.030
   Vara D, 2013, BRIT J PHARMACOL, V168, P212, DOI 10.1111/j.1476-5381.2012.02130.x
   Vinik AI, 2001, DIABETES CARE, V24, P1476, DOI 10.2337/diacare.24.8.1476
   Vizioli L, 2009, INT J CLIN PRACT, V63, P1509, DOI 10.1111/j.1742-1241.2009.02070.x
   Wan SW, 2012, J CELL BIOCHEM, V113, P1681, DOI 10.1002/jcb.24037
   Wang C, 2013, ANTIOXID REDOX SIGN, V19, P44, DOI 10.1089/ars.2012.4630
   Wang GR, 1998, P NATL ACAD SCI USA, V95, P4888, DOI 10.1073/pnas.95.9.4888
   Zai A, 1999, J CLIN INVEST, V103, P393, DOI 10.1172/JCI4890
   Zhou JS, 2015, J CLIN INVEST, V125, P4391, DOI 10.1172/JCI80319
NR 103
TC 12
Z9 13
U1 0
U2 4
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2016
VL 2016
AR 2423547
DI 10.1155/2016/2423547
PG 10
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA EF8FF
UT WOS:000390563700001
PM 28053690
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Piva, SJ
   Duarte, MMMF
   Da Cruz, IBM
   Coelho, AC
   Moreira, APL
   Tonello, R
   Garcia, SC
   Moresco, RN
AF Piva, Silvia J.
   Duarte, Marta M. M. F.
   Da Cruz, Ivana B. M.
   Coelho, Adriane C.
   Moreira, Ana Paula L.
   Tonello, Raquel
   Garcia, Solange C.
   Moresco, Rafael N.
TI Ischemia-modified albumin as an oxidative stress biomarker in obesity
SO CLINICAL BIOCHEMISTRY
LA English
DT Article
DE Human serum albumin; Obesity; Oxidative stress
ID METABOLIC SYNDROME; ASSOCIATION; INFLAMMATION; PLASMA; LIPIDS
AB Objective: We evaluated the levels of ischemia-modified albumin (IMA) and its association with body mass index (BMI) in patients who are obese.
   Design and methods: Fasting glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, malondialdehyde, and IMA levels were assessed in 148 subjects.
   Results: IMA, malondialdehyde, and fasting glucose levels were significantly higher while the HDL cholesterol levels were lower in obese population.
   Conclusions: IMA levels increase in overweight and obese subjects. (C) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
C1 [Piva, Silvia J.; Moresco, Rafael N.] Univ Fed Santa Maria, Ctr Ciencias Saude, Dept Anal Clin & Toxicol, Lab Bioquim Clin, BR-97105900 Santa Maria, RS, Brazil.
   [Piva, Silvia J.; Moreira, Ana Paula L.; Moresco, Rafael N.] Univ Fed Santa Maria, Ctr Ciencias Saude, Programa Posgrad Cieencias Farmaceut, BR-97105900 Santa Maria, RS, Brazil.
   [Duarte, Marta M. M. F.] Univ Luterana Brasil, Dept Ciencias Saude, Santa Maria, RS, Brazil.
   [Da Cruz, Ivana B. M.; Garcia, Solange C.; Moresco, Rafael N.] Univ Fed Santa Maria, Ctr Ciencias Saude, Programa Posgrad & Farmacol, BR-97105900 Santa Maria, RS, Brazil.
   [Da Cruz, Ivana B. M.; Tonello, Raquel] Univ Fed Santa Maria, Ctr Ciencias Saude, Programa Posgrad Bioquim Toxciol, BR-97105900 Santa Maria, RS, Brazil.
   [Coelho, Adriane C.] Hosp Univ Santa Maria, Santa Maria, RS, Brazil.
   [Garcia, Solange C.] Univ Fed Rio Grande do Sul, Dept Anal, Lab Toxicol, Porto Alegre, RS, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal de
   Santa Maria (UFSM); Universidade Luterana do Brasil; Universidade
   Federal de Santa Maria (UFSM); Universidade Federal de Santa Maria
   (UFSM); Universidade Federal do Rio Grande do Sul
RP Moresco, RN (corresponding author), Univ Fed Santa Maria, Ctr Ciencias Saude, Dept Anal Clin & Toxicol, Lab Bioquim Clin, Ave Roraima 1000,Predio 26,Sala 1216, BR-97105900 Santa Maria, RS, Brazil.
EM rnmoresco@yahoo.com.br
RI Garcia, Solange/J-3039-2013; da Cruz; Manica da Cruz, Ivana/G-4329-2012;
   Moresco, Rafael/K-6118-2017
OI Garcia, Solange/0000-0003-3752-5751; da Cruz; Manica da Cruz,
   Ivana/0000-0003-3008-6899; Tonello, Raquel/0000-0002-2175-9804; Moresco,
   Rafael/0000-0003-3072-5080
CR Bhagavan NV, 2009, CLIN CHEM, V55, P1588, DOI 10.1373/clinchem.2008.123315
   Bourdon E, 1999, FASEB J, V13, P233, DOI 10.1096/fasebj.13.2.233
   Duarte MMMF, 2009, CLIN BIOCHEM, V42, P666, DOI 10.1016/j.clinbiochem.2009.01.010
   Flegal KM, 2010, JAMA-J AM MED ASSOC, V303, P235, DOI 10.1001/jama.2009.2014
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Grotto D, 2007, J PHARMACEUT BIOMED, V43, P619, DOI 10.1016/j.jpba.2006.07.030
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Kaefer M, 2010, CLIN BIOCHEM, V43, P450, DOI 10.1016/j.clinbiochem.2009.11.018
   Malnick SDH, 2006, QJM-INT J MED, V99, P565, DOI 10.1093/qjmed/hcl085
   Gottlieb MGV, 2010, J CLIN ENDOCR METAB, V95, P586, DOI 10.1210/jc.2009-1592
   Vincent HK, 2006, INT J OBESITY, V30, P400, DOI 10.1038/sj.ijo.0803177
NR 11
TC 62
Z9 67
U1 2
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
EI 1873-2933
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD MAR
PY 2011
VL 44
IS 4
BP 345
EP 347
DI 10.1016/j.clinbiochem.2010.12.001
PG 3
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 724FN
UT WOS:000287561600015
PM 21159315
DA 2025-06-11
ER

PT J
AU Freitas, C
   Deschênes, S
   Au, BN
   Smith, K
   Schmitz, N
AF Freitas, Cassandra
   Deschenes, Sonya
   Au, Bonnie
   Smith, Kimberley
   Schmitz, Norbert
TI Risk of Diabetes in Older Adults with Co-Occurring Depressive Symptoms
   and Cardiometabolic Abnormalities: Prospective Analysis from the English
   Longitudinal Study of Ageing
SO PLOS ONE
LA English
DT Article
ID METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; TYPE-2; METAANALYSIS;
   ASSOCIATION; PREVALENCE; OBESITY; HYPERTENSION; INFLAMMATION; AGREEMENT
AB High depressive symptoms and cardiometabolic abnormalities are independently associated with an increased risk of diabetes. The purpose of this study was to assess the association of co-occurring depressive symptoms and cardiometabolic abnormalities on risk of diabetes in a representative sample of the English population aged 50 years and older. Data were from the English Longitudinal Study of Ageing. The sample comprised of 4454 participants without diabetes at baseline. High depressive symptoms were based on a score of 4 or more on the 8-item binary Centre for Epidemiologic Studies-Depression scale. Cardiometabolic abnormalities were defined as 3 or more cardiometabolic risk factors (hypertension, impaired glycemic control, systemic inflammation, low high-density lipoprotein cholesterol, high triglycerides, and central obesity). Cox proportional hazards regressions assessed the association between co-occurring depressive symptoms and cardiometabolic abnormalities with incidence of diabetes. Multiple imputation by chained equations was performed to account for missing data. Covariates included age, sex, education, income, smoking status, physical activity, alcohol consumption, and cardiovascular comorbidity. The follow-up period consisted of 106 months, during which 193 participants reported a diagnosis of diabetes. Diabetes incidence rates were compared across the following four groups: 1) no or low depressive symptoms and no cardiometabolic abnormalities (reference group, n = 2717); 2) high depressive symptoms only (n = 338); 3) cardiometabolic abnormalities only (n = 1180); and 4) high depressive symptoms and cardiometabolic abnormalities (n = 219). Compared to the reference group, the hazard ratio for diabetes was 1.29 (95% CI 0.63, 2.64) for those with high depressive symptoms only, 3.88 (95% CI 2.77, 5.44) for those with cardiometabolic abnormalities only, and 5.56 (95% CI 3.45, 8.94) for those with both high depressive symptoms and cardiometabolic abnormalities, after adjusting for socio-demographic, lifestyle and clinical variables. These findings suggest that those with high depressive symptoms and cardiometabolic abnormalities are at a particularly increased risk of type 2 diabetes.
C1 [Freitas, Cassandra; Schmitz, Norbert] McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.
   [Freitas, Cassandra; Deschenes, Sonya; Schmitz, Norbert] Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada.
   [Deschenes, Sonya; Schmitz, Norbert] McGill Univ, Dept Psychiat, Montreal, PQ, Canada.
   [Au, Bonnie] Sunnybrook Hlth Sci Ctr, Primary Care Res Unit, Toronto, ON M4N 3M5, Canada.
   [Smith, Kimberley] Brunel Univ London, Dept Life Sci, Uxbridge, Middx, England.
C3 McGill University; McGill University; University of Toronto; Sunnybrook
   Research Institute; Sunnybrook Health Science Center; Brunel University
RP Freitas, C (corresponding author), McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.; Freitas, C (corresponding author), Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada.
EM cassandra.freitas@mail.mcgill.ca
RI Deschenes, Sonya/G-6341-2017; Schmitz, Norbert/AAH-3624-2020; Schmitz,
   Norbert/A-5177-2010
OI Smith, Kimberley/0000-0002-1323-627X; Schmitz,
   Norbert/0000-0001-7777-6323
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Andersson T, 2005, EUR J EPIDEMIOL, V20, P575, DOI 10.1007/s10654-005-7835-x
   [Anonymous], 2021, Modern Epidemiology
   [Anonymous], 2015, MY COMM AW PROGR OLD
   [Anonymous], INT J EPIDEMIOLOGY
   [Anonymous], 2014, DIAB PUBL HLTH RES M
   Assmann SF, 1996, EPIDEMIOLOGY, V7, P286, DOI 10.1097/00001648-199605000-00012
   Au B, 2014, J PSYCHOSOM RES, V77, P180, DOI 10.1016/j.jpsychores.2014.07.012
   Azur MJ, 2011, INT J METH PSYCH RES, V20, P40, DOI 10.1002/mpr.329
   Council S, 1992, ALLIED DUNBAR NATL F
   Cracknell R., 2010, Key Issues for the New Parliament, V2010, P44
   Demakakos P, 2010, DIABETOLOGIA, V53, P1877, DOI 10.1007/s00125-010-1785-x
   Demakakos P, 2010, DIABETES CARE, V33, P792, DOI 10.2337/dc09-1663
   El Fakiri F, 2007, J CLIN EPIDEMIOL, V60, P1271, DOI 10.1016/j.jclinepi.2007.02.014
   Ervin R Bethene, 2009, Natl Health Stat Report, P1
   Esteve E, 2005, CLIN NUTR, V24, P16, DOI 10.1016/j.clnu.2004.08.004
   Ford ES, 2008, CARDIOVASC DIABETOL, V7, DOI 10.1186/1475-2840-7-35
   Freitas C, 2015, INT J GERIATR PSYCHI
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Hamer M, 2009, PSYCHONEUROENDOCRINO, V34, P1050, DOI 10.1016/j.psyneuen.2009.02.004
   Holman N, 2011, DIABETIC MED, V28, P575, DOI 10.1111/j.1464-5491.2010.03216.x
   International Diabetes Federation, 2014, IDF DIAB ATL UPD POS
   Jacoby R., 2002, Psychiatry in the Elderly, V3rd
   Jokela M, 2014, MOL PSYCHIATR, V19, P910, DOI 10.1038/mp.2013.162
   Jones C, 2013, WALES SCOTLAND UK
   Jones GRD, 2011, MED J AUSTRALIA, V195, P45, DOI 10.5694/j.1326-5377.2011.tb03190.x
   Kirkman MS, 2012, DIABETES CARE, V35, P2650, DOI 10.2337/dc12-1801
   Knol MJ, 2006, DIABETOLOGIA, V49, P837, DOI 10.1007/s00125-006-0159-x
   Lichtenstein AH, 2006, CIRCULATION, V114, P82, DOI 10.1161/CIRCULATIONAHA.106.176158
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Musselman DL, 2003, BIOL PSYCHIAT, V54, P317, DOI 10.1016/S0006-3223(03)00569-9
   Nathan DM, 2009, DIABETES CARE, V32, P1327, DOI 10.2337/dc09-9033
   Saad MAN, 2014, ARQ BRAS CARDIOL, V102, P263, DOI 10.5935/abc.20140013
   Okura Y, J CLIN EPIDEMIOLOGY, V57, P1096
   Osborn O, 2012, NAT MED, V18, P363, DOI 10.1038/nm.2627
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Patel SB, 2008, CURR HYPERTENS REP, V10, P131, DOI 10.1007/s11906-008-0025-y
   Pearson TA, 2003, CIRCULATION, V107, P499, DOI 10.1161/01.CIR.0000052939.59093.45
   Penninx BWJH, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-129
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Raghunathan TE, 2004, ANNU REV PUBL HEALTH, V25, P99, DOI 10.1146/annurev.publhealth.25.102802.124410
   Rotella F, 2013, J CLIN PSYCHIAT, V74, P32, DOI 10.4088/JCP.12r07922
   Rothman K., 2002, EPIDEMIOLOGY INTRO
   Schmitz N, 2007, PSYCHOSOM MED, V69, P332, DOI 10.1097/PSY.0b013e31804259e0
   Steffick DE, 2000, DOCUMENTION AFFECTIV
   The University of Wisconsin-Madison Social Science Computing Cooperative, 2013, MULT IMP STAT
   Turvey C L, 1999, Int Psychogeriatr, V11, P139, DOI 10.1017/S1041610299005694
   van Dieren S, 2010, EUR J CARDIOV PREV R, V17, pS3, DOI 10.1097/01.hjr.0000368191.86614.5a
   Vogelzangs N, 2011, J CLIN PSYCHIAT, V72, P598, DOI 10.4088/JCP.10m06559
   Wang X, 2013, DIABETES CARE, V36, P166, DOI 10.2337/dc12-0702
   Whiting DR, 2011, DIABETES RES CLIN PR, V94, P311, DOI 10.1016/j.diabres.2011.10.029
   Wildman RP, 2008, ARCH INTERN MED, V168, P1617, DOI 10.1001/archinte.168.15.1617
NR 53
TC 13
Z9 17
U1 0
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 26
PY 2016
VL 11
IS 5
AR e0155741
DI 10.1371/journal.pone.0155741
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA DN2GQ
UT WOS:000376882500030
PM 27227974
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Gapelyuk, A
   Wessel, N
   Fischer, R
   Zacharzowsky, U
   Koch, L
   Selbig, D
   Schütt, H
   Sawitzki, B
   Lutt, FC
   Dietz, R
   Schirdewan, A
AF Gapelyuk, Andrej
   Wessel, Niels
   Fischer, Robert
   Zacharzowsky, Udo
   Koch, Lydia
   Selbig, Daniela
   Schuett, Henry
   Sawitzki, Bianca
   Lutt, Friedrich C.
   Dietz, Rainer
   Schirdewan, Alexander
TI Detection of patients with coronary artery disease using cardiac
   magnetic field mapping at rest
SO JOURNAL OF ELECTROCARDIOLOGY
LA English
DT Article
DE cardiac magnetic field mapping; coronary artery
ID ISCHEMIC-HEART-DISEASE; MYOCARDIAL ABNORMALITY; ST DEPRESSION;
   SYNDROME-X; MAGNETOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; ENDOTHELIUM;
   MECHANISM; DIAGNOSIS; SIGNAL
AB We studied the use of cardiac magnetic field mapping to detect patients with CAD without subjecting them to stress. Fifty-nine healthy control subjects and 10 1 patients with CAD without previous MI were included. The optimal positions for detecting CAD were located in the left superior parasternal and in the inferior midsternal area. Values for ST slope, ST shift, T peak amplitude, ST-T integral, and magnetic field map orientation differed significantly between the 2 groups. Three parameters together in a inultivariate analysis yielded a sensitivity of 84% and a specificity of 83% in distinguishing patients with CAD from control subjects. We suggest that cardiac magnetic field mapping is a promising technique to identify patients with CAD. (c) 2007 Elsevier Inc. All rights reserved.
C1 HELIOS Klin, Franz Volhard Klin, Fac Med Charite, Berlin, Germany.
   Univ Potsdam, Dept Phys, Potsdam, Germany.
   Max Delbruck Ctr Mol Med, Berlin, Germany.
C3 Helios Kliniken; Berlin Institute of Health; Free University of Berlin;
   Humboldt University of Berlin; Charite Universitatsmedizin Berlin;
   Franz-Volhard Clinical Research Center; University of Potsdam; Helmholtz
   Association; Max Delbruck Center for Molecular Medicine
RP Schirdewan, A (corresponding author), HELIOS Klin, Franz Volhard Klin, Fac Med Charite, Berlin, Germany.
EM alexander.schirdewan@charite.de
OI Wessel, Niels/0000-0003-0922-9971; Luft, Friedrich/0000-0002-8635-1199
CR Britten MB, 1999, J INTERN MED, V245, P315, DOI 10.1046/j.1365-2796.1999.00449.x
   DETRANO R, 1991, J ELECTROCARDIOL S, V24, P54
   Dutz S, 2006, PHYS MED BIOL, V51, P145, DOI 10.1088/0031-9155/51/1/011
   Faley MI, 2002, APPL PHYS LETT, V81, P2406, DOI 10.1063/1.1508419
   Froelicher VF, 1998, ANN INTERN MED, V128, P965, DOI 10.7326/0003-4819-128-12_Part_1-199806150-00001
   GIANROSSI R, 1989, CIRCULATION, V80, P87, DOI 10.1161/01.CIR.80.1.87
   Gibbons RJ, 1997, J AM COLL CARDIOL, V30, P260
   Hailer B, 2005, PACE, V28, P8, DOI 10.1111/j.1540-8159.2005.09318.x
   Hanninen H., 2000, Annals of Noninvasive Electrocardiology, V5, P147, DOI 10.1111/j.1542-474X.2000.tb00380.x
   HANNINEN H, 2002, ANN MED, P24
   Hopenfeld B, 2004, J CARDIOVASC ELECTR, V15, P1200, DOI 10.1046/j.1540-8167.2004.04072.x
   Kandori A, 2001, MED BIOL ENG COMPUT, V39, P21, DOI 10.1007/BF02345262
   Kandori A, 2001, MED BIOL ENG COMPUT, V39, P29, DOI 10.1007/BF02345263
   Koch H, 2004, J ELECTROCARDIOL, V37, P117, DOI 10.1016/j.jelectrocard.2004.08.035
   Koller A, 2002, MICROCIRCULATION, V9, P277, DOI 10.1038/sj.mn.7800142
   KORNREICH F, 1991, CIRCULATION, V84, P2442, DOI 10.1161/01.CIR.84.6.2442
   KOSCH O, 2001, BIOMAG 2000, P553
   LANT J, 1990, J ELECTROCARDIOL, V23, P315, DOI 10.1016/0022-0736(90)90121-H
   Leder U, 1998, INT J CARDIOL, V64, P83, DOI 10.1016/S0167-5273(97)00326-4
   MALMIVUO J, 2000, INT J BIOELECTROMAGN, V2, P1
   Malmivuo J., 2012, Bioelectromagnetism: Principles and Applications of Bioelectric and Biomagnetic Fields
   MASERI A, 1985, AM J CARDIOL, V56, pE31
   Maslennikov Yu., 2002, P 13 INT C BIOM BIOM, P946
   NABEL EG, 1990, J AM COLL CARDIOL, V16, P349, DOI 10.1016/0735-1097(90)90584-C
   Panting JR, 2002, NEW ENGL J MED, V346, P1948, DOI 10.1056/NEJMoa012369
   PLONSEY R, 1972, IEEE T BIO-MED ENG, VBM19, P239, DOI 10.1109/TBME.1972.324123
   RUSH S, 1975, IEEE T BIO-MED ENG, VBM22, P157, DOI 10.1109/TBME.1975.324555
   Satake O, 2004, CIRC J, V68, P220, DOI 10.1253/circj.68.220
   SILTANEN P, 1989, COMPREHENSIVE ELECTR, V2, P1408
   Simula S, 2002, J NUCL MED, V43, P1
   STUART RJ, 1980, CHEST, V77, P94, DOI 10.1378/chest.77.1.94
   Takala P, 2002, BASIC RES CARDIOL, V97, P88, DOI 10.1007/s395-002-8391-y
   Tsukada K, 2000, INT J CARDIAC IMAG, V16, P55, DOI 10.1023/A:1006376326755
   Turkmen M, 2004, JPN HEART J, V45, P419, DOI 10.1536/jhj.45.419
   VANLEEUWEN P, 1997, BIOMED TECH BERL, V42, P32
   VANLEEUWEN P, 1999, MED BIOL ENG COMPUT, V37, P1482
NR 36
TC 18
Z9 18
U1 1
U2 7
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI PHILADELPHIA
PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA
SN 0022-0736
J9 J ELECTROCARDIOL
JI J. Electrocardiol.
PD SEP-OCT
PY 2007
VL 40
IS 5
BP 401
EP 407
DI 10.1016/j.jelectrocard.2007.03.013
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 211EU
UT WOS:000249507900008
PM 17531250
DA 2025-06-11
ER

PT J
AU Araújo, JR
   Martel, F
   Keating, E
AF Araujo, Joao Ricardo
   Martel, Fatima
   Keating, Elisa
TI Exposure to non-nutritive sweeteners during pregnancy and lactation:
   Impact in programming of metabolic diseases in the progeny later in life
SO REPRODUCTIVE TOXICOLOGY
LA English
DT Review
DE Non-nutritive sweeteners; Pregnancy; Fetal programming; Metabolic
   syndrome
ID HIGH-INTENSITY SWEETENERS; ARTIFICIAL SWEETENERS; ACESULFAME-K;
   BODY-WEIGHT; FOOD-INTAKE; PRETERM DELIVERY; OXIDATIVE STRESS; GUT
   MICROBIOTA; ASPARTAME; RAT
AB The nutritional environment during embryonic, fetal and neonatal development plays a crucial role in the offspring's risk of developing diseases later in life. Although non-nutritive sweeteners (NNS) provide sweet taste without contributing to energy intake, animal studies showed that long-term consumption of NSS, particularly aspartame, starting during the perigestational period may predispose the offspring to develop obesity and metabolic syndrome later in life. In this paper, we review the impact of NNS exposure during the perigestational period on the long-term disease risk of the offspring, with a particular focus on metabolic diseases. Some mechanisms underlying NNS adverse metabolic effects have been proposed, such as an increase in intestinal glucose absorption, alterations in intestinal microbiota, induction of oxidative stress and a dysregulation of appetite and reward responses. The data reviewed herein suggest that NNS consumption by pregnant and lactating women should be looked with particular caution and requires further research. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Araujo, Joao Ricardo; Martel, Fatima; Keating, Elisa] Univ Porto, Dept Biochem FCT U38, Fac Med, P-4200319 Porto, Portugal.
   [Keating, Elisa] Portuguese Catholic Univ, Sch Biotechnol, Ctr Biotechnol & Fine Chem, P-4200702 Porto, Portugal.
C3 Universidade do Porto; Universidade Catolica Portuguesa
RP Araújo, JR (corresponding author), Univ Porto, Dept Biochem FCT U38, Fac Med, P-4200319 Porto, Portugal.
EM jaraujo@med.up.pt
RI Martel, Felix/JFJ-0587-2023; Araújo, João/GRY-7522-2022; Keating,
   Elisa/JDW-8704-2023
OI Keating, Elisa/0000-0002-3904-9907; Martel, Fatima/0000-0002-0525-3416;
   Araujo, Joao Ricardo/0000-0003-2491-1047
FU Fundacao para a Ciencia e a Tecnologia (FCT); COMPETE; QREN; FEDER
   [SFRH/BD/63086/2009]; Fundação para a Ciência e a Tecnologia
   [SFRH/BD/63086/2009] Funding Source: FCT
FX This work was supported by Fundacao para a Ciencia e a Tecnologia (FCT)
   and COMPETE, QREN and FEDER (SFRH/BD/63086/2009).
CR Abdel-Salam OME, 2012, NEUROTOX RES, V21, P245, DOI 10.1007/s12640-011-9264-9
   Abhilash M, 2011, FOOD CHEM TOXICOL, V49, P1203, DOI 10.1016/j.fct.2011.02.019
   Abou-Donia MB, 2008, J TOXICOL ENV HEAL A, V71, P1415, DOI 10.1080/15287390802328630
   Bellisle F, 2012, J NUTR, V142, p1149S, DOI 10.3945/jn.111.149583
   Brenseke B, 2013, J PREGNANCY, V2013, DOI 10.1155/2013/368461
   Brown RJ, 2010, INT J PEDIATR OBES, V5, P305, DOI 10.3109/17477160903497027
   Chen ML, 2013, CHEM SENSES, V38, P447, DOI 10.1093/chemse/bjt001
   Collison KS, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-58
   Collison KS, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031570
   CONG WN, 2013, PLOS ONE, V13
   EFSA (European Food Safety Authority), 2010, EFSA J, V8, P1507
   Englund-Ögge L, 2012, AM J CLIN NUTR, V96, P552, DOI 10.3945/ajcn.111.031567
   *FDA, 2014, FOOD ADDITIVES PERMI
   Feng ZH, 2012, ANTIOXID REDOX SIGN, V16, P275, DOI 10.1089/ars.2010.3750
   Fitch C, 2012, J ACAD NUTR DIET, V112, P739, DOI 10.1016/j.jand.2012.03.009
   Flint HJ, 2012, NAT REV GASTRO HEPAT, V9, P577, DOI 10.1038/nrgastro.2012.156
   Fowler SP, 2008, OBESITY, V16, P1894, DOI 10.1038/oby.2008.284
   Gardner C, 2012, DIABETES CARE, V35, P1798, DOI 10.2337/dc12-9002
   Halldorsson TI, 2010, AM J CLIN NUTR, V92, P626, DOI 10.3945/ajcn.2009.28968
   Ilbäck NG, 2003, FOOD ADDIT CONTAM A, V20, P99, DOI 10.1080/0265203021000042896
   Ishimaru Y, 2009, J DENT RES, V88, P212, DOI 10.1177/0022034508330212
   Johnson RJ, 2013, DIABETES, V62, P3307, DOI 10.2337/db12-1814
   Jou MY, 2012, PEDIATR RES, V71, P228, DOI 10.1038/pr.2011.44
   Kille JW, 2000, FOOD CHEM TOXICOL, V38, pS43, DOI 10.1016/S0278-6915(00)00027-2
   KLINE J, 1978, AM J OBSTET GYNECOL, V130, P708, DOI 10.1016/0002-9378(78)90333-2
   Lakshmy R, 2013, REV ENDOCR METAB DIS, V14, P229, DOI 10.1007/s11154-013-9266-4
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Liu B, 2011, J NEUROSCI, V31, P11070, DOI 10.1523/JNEUROSCI.0791-11.2011
   Ludwig DS, 2013, JAMA-J AM MED ASSOC, V310, P33, DOI 10.1001/jama.2013.6562
   Mace OJ, 2007, J PHYSIOL-LONDON, V582, P379, DOI 10.1113/jphysiol.2007.130906
   Magnuson BA, 2007, CRIT REV TOXICOL, V37, P629, DOI 10.1080/10408440701516184
   Magnuson B, 2008, ENVIRON HEALTH PERSP, V116, pA239, DOI 10.1289/ehp.10881
   Margolskee RF, 2007, P NATL ACAD SCI USA, V104, P15075, DOI 10.1073/pnas.0706678104
   Maslova E, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057261
   Mischke M, 2013, AM J PHYSIOL-REG I, V304, pR1065, DOI 10.1152/ajpregu.00551.2012
   Nettleton JA, 2009, DIABETES CARE, V32, P688, DOI 10.2337/dc08-1799
   Oron-Herman M, 2008, AM J HYPERTENS, V21, P1018, DOI 10.1038/ajh.2008.218
   Parlee SD, 2014, ENDOCRINOLOGY, V155, P1313, DOI 10.1210/en.2013-1995
   Pepino MY, 2011, CURR OPIN CLIN NUTR, V14, P391, DOI 10.1097/MCO.0b013e3283468e7e
   Pereira MA, 2013, CURR ATHEROSCLER REP, V15, DOI 10.1007/s11883-013-0375-z
   Pérez-Torres I, 2011, CAN J PHYSIOL PHARM, V89, P899, DOI [10.1139/y11-086, 10.1139/Y11-086]
   Raben A, 2002, AM J CLIN NUTR, V76, P721, DOI 10.1093/ajcn/76.4.721
   Ramos EJB, 2005, NUTRITION, V21, P269, DOI 10.1016/j.nut.2004.06.021
   RAWANA S, 1993, J NUTR, V123, P2158
   Rawls JF, 2007, CELL HOST MICROBE, V2, P73, DOI 10.1016/j.chom.2007.07.006
   Rexhaj E, 2011, AM J PHYSIOL-HEART C, V301, pH247, DOI 10.1152/ajpheart.01309.2010
   Roseboom TJ, 2001, MOL CELL ENDOCRINOL, V185, P93, DOI 10.1016/S0303-7207(01)00721-3
   Samuelsson AM, 2013, FRONT PHYSIOL, V4, DOI 10.3389/fphys.2013.00014
   Sato S, 2013, AM J PHYSIOL-GASTR L, V304, pG708, DOI 10.1152/ajpgi.00282.2012
   Soffritti M, 2006, ENVIRON HEALTH PERSP, V114, P379, DOI 10.1289/ehp.8711
   Soffritti M, 2008, BASIC CLIN PHARMACOL, V102, P118, DOI 10.1111/j.1742-7843.2007.00200.x
   Soffritti M, 2007, ENVIRON HEALTH PERSP, V115, P1293, DOI 10.1289/ehp.10271
   Soffritti M, 2010, AM J IND MED, V53, P1197, DOI 10.1002/ajim.20896
   STURTEVANT FM, 1985, INT J FERTIL, V30, P85
   Swartz TD, 2012, BRIT J NUTR, V107, P621, DOI 10.1017/S0007114511003412
   Swithers SE, 2013, TRENDS ENDOCRIN MET, V24, P431, DOI 10.1016/j.tem.2013.05.005
   Swithers SE, 2013, BEHAV NEUROSCI, V127, P262, DOI 10.1037/a0031717
   Swithers SE, 2009, BEHAV NEUROSCI, V123, P772, DOI 10.1037/a0016139
   Sylvetsky A, 2011, PEDIATR CLIN N AM, V58, P1467, DOI 10.1016/j.pcl.2011.09.007
   Thompson LP, 2012, J PREGNANCY, V2012, DOI 10.1155/2012/582748
   TORDOFF MG, 1990, AM J CLIN NUTR, V51, P963, DOI 10.1093/ajcn/51.6.963
   Trocho C, 1998, LIFE SCI, V63, P337, DOI 10.1016/S0024-3205(98)00282-3
   Vickers MH, 2011, ENDOCRINOLOGY, V152, P1378, DOI 10.1210/en.2010-1093
   Vijay-Kumar M, 2007, J CLIN INVEST, V117, P3909, DOI 10.1172/JCI33084
   Wu TZ, 2012, AM J CLIN NUTR, V95, P78, DOI 10.3945/ajcn.111.021543
   YODYINGYUAD V, 1991, HUM REPROD, V6, P158, DOI 10.1093/oxfordjournals.humrep.a137251
   Zhang GH, 2011, CHEM SENSES, V36, P763, DOI 10.1093/chemse/bjr050
   Zheng Y, 2013, J GASTROINTEST SURG, V17, P153, DOI 10.1007/s11605-012-1998-z
NR 69
TC 45
Z9 49
U1 0
U2 85
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0890-6238
J9 REPROD TOXICOL
JI Reprod. Toxicol.
PD NOV
PY 2014
VL 49
BP 196
EP 201
DI 10.1016/j.reprotox.2014.09.007
PG 6
WC Reproductive Biology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Reproductive Biology; Toxicology
GA AT9PC
UT WOS:000345257900020
PM 25263228
DA 2025-06-11
ER

PT J
AU Semchyshyn, HM
AF Semchyshyn, H. M.
TI Fructation In Vivo: Detrimental and Protective Effects of
   Fructose
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Review
ID BOVINE SERUM-ALBUMIN; MAILLARD REACTION; OXIDATIVE STRESS; DIETARY
   FRUCTOSE; NONENZYMATIC GLYCATION; SUPEROXIDE-DISMUTASE; METABOLIC
   SYNDROME; DIABETES-MELLITUS; PROTEIN GLYCATION; CARBONYL STRESS
AB There is compelling evidence that long-term intake of excessive fructose can have deleterious side effects in different experimental models. However, the role of fructose in vivo remains controversial, since acute temporary application of fructose is found to protect yeast as well as animal tissues against exogenous oxidative stress. This review suggests the involvement of reactive carbonyl and oxygen species in both the cytotoxic and defensive effects of fructose. Potential mechanisms of the generation of reactive species by fructose in the nonenzymatic reactions, their implication in the detrimental and protective effects of fructose are discussed.
C1 Vassyl Stefanyk Precarpathian Natl Univ, Dept Biochem & Biotechnol, UA-76025 Ivano Frankivsk, Ukraine.
C3 Ministry of Education & Science of Ukraine; Vasyl Stefanyk Precarpathian
   National University
RP Semchyshyn, HM (corresponding author), Vassyl Stefanyk Precarpathian Natl Univ, Dept Biochem & Biotechnol, 57 Shevchenko St, UA-76025 Ivano Frankivsk, Ukraine.
EM semchyshyn@pu.if.ua
RI Semchyshyn, Halyna/AAW-1597-2021
OI Semchyshyn, Halyna/0000-0002-5967-2165
CR [Anonymous], 2011, LEPTIN HORMONAL FUNC
   [Anonymous], ACS S SERIES
   Bayliak MM, 2007, CENT EUR J BIOL, V2, P326, DOI 10.2478/s11535-007-0021-2
   Berry DB, 2008, MOL BIOL CELL, V19, P4580, DOI 10.1091/mbc.E07-07-0680
   Bogdanovic J, 2008, EUR BIOPHYS J BIOPHY, V37, P1241, DOI 10.1007/s00249-008-0260-9
   Bray GA, 2013, ADV NUTR, V4, P220, DOI 10.3945/an.112.002816
   Brieger K, 2012, SWISS MED WKLY, V142, DOI 10.4414/smw.2012.13659
   BUNN HF, 1981, SCIENCE, V213, P222, DOI 10.1126/science.12192669
   CERAMI A, 1985, J AM GERIATR SOC, V33, P626, DOI 10.1111/j.1532-5415.1985.tb06319.x
   Cocinero EJ, 2013, J AM CHEM SOC, V135, P2845, DOI 10.1021/ja312393m
   COLLINSON LP, 1992, J GEN MICROBIOL, V138, P329, DOI 10.1099/00221287-138-2-329
   Cummings BP, 2010, AM J PHYSIOL-REG I, V298, pR1343, DOI 10.1152/ajpregu.00468.2009
   Dekker MJ, 2010, AM J PHYSIOL-ENDOC M, V299, pE685, DOI 10.1152/ajpendo.00283.2010
   DILLS WL, 1993, AM J CLIN NUTR, V58, P779, DOI 10.1093/ajcn/58.5.779S
   Dong QA, 2010, CHEM-BIOL INTERACT, V188, P31, DOI 10.1016/j.cbi.2010.06.006
   DYER DG, 1991, Z ERNAHRUNGSWISS, V30, P29, DOI 10.1007/BF01910730
   Ellis EM, 2007, PHARMACOL THERAPEUT, V115, P13, DOI 10.1016/j.pharmthera.2007.03.015
   Finot PA., 1982, DIABETES, V31, P22, DOI DOI 10.2337/DIAB.31.3.S22
   Forman HJ, 2010, ANN NY ACAD SCI, V1203, P35, DOI 10.1111/j.1749-6632.2010.05551.x
   Gaby AR, 2005, ALTERN MED REV, V10, P294
   HAYASHI T, 1980, AGR BIOL CHEM TOKYO, V44, P2575, DOI 10.1080/00021369.1980.10864377
   HAYWARD LD, 1977, CARBOHYD RES, V53, P13
   HODGE JE, 1953, J AGR FOOD CHEM, V1, P928, DOI 10.1021/jf60015a004
   HUNT JV, 1988, BIOCHEM J, V256, P205, DOI 10.1042/bj2560205
   Inoue Y, 2011, SEMIN CELL DEV BIOL, V22, P278, DOI 10.1016/j.semcdb.2011.02.002
   Jochen FA, 2002, BBA-MOL CELL RES, V1542, P82, DOI 10.1016/S0167-4889(01)00169-0
   Johnson RJ, 2007, AM J CLIN NUTR, V86, P899
   Karalius VP, 2013, ADV CHRONIC KIDNEY D, V20, P157, DOI 10.1053/j.ackd.2012.12.005
   Krajcovicová-Kudlácková M, 2002, PHYSIOL RES, V51, P313, DOI 10.33549/physiolres.930200
   Lanaspa MA, 2011, SEMIN NEPHROL, V31, P426, DOI 10.1016/j.semnephrol.2011.08.006
   Lawrence GD, 2008, CARBOHYD RES, V343, P626, DOI 10.1016/j.carres.2007.12.016
   Lee O, 2009, CHEM-BIOL INTERACT, V178, P332, DOI 10.1016/j.cbi.2008.10.011
   Levi B, 2003, J NUTR BIOCHEM, V14, P49, DOI 10.1016/S0955-2863(02)00254-1
   Levi B, 1998, J NUTR, V128, P1442, DOI 10.1093/jn/128.9.1442
   Levi B, 2001, J NUTR BIOCHEM, V12, P235, DOI 10.1016/S0955-2863(00)00158-3
   Lopes RP, 2006, INFLAMM RES, V55, P354, DOI 10.1007/s00011-006-6044-8
   Lozins'ka L M, 2011, Ukr Biokhim Zh (1999), V83, P67
   Lushchak OV, 2011, COMP BIOCHEM PHYS A, V160, P27, DOI 10.1016/j.cbpa.2011.04.019
   Lushchak VI, 2011, COMP BIOCHEM PHYS C, V153, P175, DOI 10.1016/j.cbpc.2010.10.004
   MacAllister SL, 2011, CHEM-BIOL INTERACT, V191, P308, DOI 10.1016/j.cbi.2011.01.017
   Maillard LC, 1912, CR HEBD ACAD SCI, V155, P1554
   Maillard LC, 1912, CR HEBD ACAD SCI, V154, P66
   Marangos P J, 1998, Expert Opin Investig Drugs, V7, P615, DOI 10.1517/13543784.7.4.615
   Mesquita A, 2010, P NATL ACAD SCI USA, V107, P15123, DOI 10.1073/pnas.1004432107
   Miyata T, 1999, KIDNEY INT, V55, P389, DOI 10.1046/j.1523-1755.1999.00302.x
   Moheimani F, 2010, BBA-MOL BASIS DIS, V1802, P561, DOI 10.1016/j.bbadis.2010.02.007
   MONNIER VM, 1981, SCIENCE, V211, P491, DOI 10.1126/science.6779377
   MULLARKEY CJ, 1990, BIOCHEM BIOPH RES CO, V173, P932, DOI 10.1016/S0006-291X(05)80875-7
   Muntané J, 2006, CRIT CARE MED, V34, P927, DOI 10.1097/01.CCM.0000202436.45295.6E
   Peng XF, 2011, FOOD FUNCT, V2, P289, DOI 10.1039/c1fo10034c
   Pohanka M., 2013, FOLIA MICROBIOLOGICA
   RAHBAR S, 1969, BIOCHEM BIOPH RES CO, V36, P838, DOI 10.1016/0006-291X(69)90685-8
   RAHBAR S, 1968, CLIN CHIM ACTA, V20, P381, DOI 10.1016/0009-8981(68)90293-3
   Rangsansarid J, 2008, J OLEO SCI, V57, P539, DOI 10.5650/jos.57.539
   Rebollo A, 2012, WORLD J GASTROENTERO, V18, P6552, DOI 10.3748/wjg.v18.i45.6552
   Reihl O, 2004, CARBOHYD RES, V339, P1609, DOI 10.1016/j.carres.2004.03.024
   Riedel BJ, 2004, ANESTH ANALG, V98, P20, DOI 10.1213/01.ANE.0000094336.97693.90
   Rippe JM, 2013, ADV NUTR, V4, P236, DOI 10.3945/an.112.002824
   Robert L, 2011, PATHOL BIOL, V59, P321, DOI 10.1016/j.patbio.2011.04.007
   Robert L, 2010, PATHOL BIOL, V58, P200, DOI 10.1016/j.patbio.2009.09.004
   Sakai Makoto, 2002, Kobe Journal of Medical Sciences, V48, P125
   Sáchez-Lozada LG, 2008, AM J CLIN NUTR, V88, P1189, DOI 10.3945/ajcn.2008.26812
   Semchyshyn H, 2009, CENT EUR J BIOL, V4, P142, DOI 10.2478/s11535-009-0005-5
   Semchyshyn HM, 2012, FEMS YEAST RES, V12, P761, DOI 10.1111/j.1567-1364.2012.00826.x
   Semchyshyn HM, 2011, REDOX REP, V16, P15, DOI 10.1179/174329211X12968219310954
   Semchyshyn HM, 2011, CARBOHYD RES, V346, P933, DOI 10.1016/j.carres.2011.03.005
   Semchyshyn HM, 2012, OXIDATIVE STRESS MOL, V16, P15
   Shumaev KB, 2009, BIOCHEMISTRY-MOSCOW+, V74, P461, DOI 10.1134/S0006297909040154
   Smuda M, 2011, J AGR FOOD CHEM, V59, P13254, DOI 10.1021/jf203346b
   Soleimani M, 2011, ACTA PHYSIOL, V201, P55, DOI 10.1111/j.1748-1716.2010.02167.x
   Spasojevic I, 2012, OXID MED CELL LONGEV, V2012, DOI 10.1155/2012/596019
   Spasojevic I, 2009, CARBOHYD RES, V344, P80, DOI 10.1016/j.carres.2008.09.025
   Spaspjevic I, 2009, CARBOHYD RES, V344, P1676, DOI 10.1016/j.carres.2009.05.023
   Stanhope KL, 2013, CURR OPIN LIPIDOL, V24, P198, DOI 10.1097/MOL.0b013e3283613bca
   Stanhope KL, 2009, J CLIN INVEST, V119, P1322, DOI 10.1172/JCI37385
   SUAREZ G, 1989, J BIOL CHEM, V264, P3674
   SUAREZ G, 1991, BIOCHIM BIOPHYS ACTA, V1075, P12, DOI 10.1016/0304-4165(91)90068-R
   Takamiya R, 2003, FASEB J, V17, P938, DOI 10.1096/fj.02-0768fje
   Tappy L, 2012, BMC BIOL, V10, DOI 10.1186/1741-7007-10-42
   Tappy L, 2010, NUTRITION, V26, P1044, DOI 10.1016/j.nut.2010.02.014
   Tappy L, 2010, PHYSIOL REV, V90, P23, DOI 10.1152/physrev.00019.2009
   Tessier FJ, 2010, PATHOL BIOL, V58, P214, DOI 10.1016/j.patbio.2009.09.014
   THORNALLEY P, 1984, BIOCHIM BIOPHYS ACTA, V797, P276, DOI 10.1016/0304-4165(84)90131-4
   Thornalley PJ, 2005, ANN NY ACAD SCI, V1043, P111, DOI 10.1196/annals.1333.014
   THORNALLEY PJ, 1990, BIOCHEM J, V269, P1
   Turk Z, 2010, PHYSIOL RES, V59, P147, DOI 10.33549/physiolres.931585
   Valeri F, 1997, FREE RADICAL BIO MED, V22, P257, DOI 10.1016/S0891-5849(96)00331-0
   Vilà L, 2011, J NUTR BIOCHEM, V22, P741, DOI 10.1016/j.jnutbio.2010.06.005
   White JS, 2013, ADV NUTR, V4, P246, DOI 10.3945/an.112.003137
   Wijewickreme AN, 1997, J AGR FOOD CHEM, V45, P4577, DOI 10.1021/jf970041n
   WOLFF SP, 1991, FREE RADICAL BIO MED, V10, P339, DOI 10.1016/0891-5849(91)90040-A
   Xue MZ, 2011, SEMIN CELL DEV BIOL, V22, P293, DOI 10.1016/j.semcdb.2011.02.013
   Yang K, 2011, CHEM-BIOL INTERACT, V191, P315, DOI 10.1016/j.cbi.2011.02.027
   YATSCOFF RW, 1984, CLIN CHEM, V30, P446
   Yeboah FK, 1999, J AGR FOOD CHEM, V47, P3164, DOI 10.1021/jf981289v
   Yim MB, 2001, ANN NY ACAD SCI, V928, P48, DOI 10.1111/j.1749-6632.2001.tb05634.x
NR 96
TC 46
Z9 49
U1 1
U2 12
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2013
VL 2013
AR 343914
DI 10.1155/2013/343914
PG 9
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 194OR
UT WOS:000322643100001
PM 23984346
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Araldi, E
   Suarez, Y
AF Araldi, Elisa
   Suarez, Yajaira
TI MicroRNAs as regulators of endothelial cell functions in cardiometabolic
   diseases
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
LA English
DT Article
DE Endothelial cells; Metabolic syndrome; MicroRNAs; Atherosclerosis; Type
   2 diabetes; Cardiovascular disease
ID FLOW-DEPENDENT REGULATION; SMOOTH-MUSCLE-CELLS; IN-VIVO;
   CARDIOVASCULAR-DISEASE; INFLAMMATORY RESPONSE; GROWTH-FACTOR;
   SHEAR-STRESS; ANGIOGENIC RESPONSE; SIGNALING PATHWAYS;
   INSULIN-RESISTANCE
AB Endothelial cells (ECs) provide nutrients and oxygen essential for tissue homeostasis. Metabolic imbalances and other environmental stimuli, like cytokines or low shear stress, trigger endothelial inflammation, increase permeability, compromise vascular tone, promote cell proliferation, and ultimately cause cell death. These factors contribute to EC dysfunction, which is crucial in the development of cardiometabolic diseases. microRNAs (miRNAs) are small non-coding RNAs that have important functions in the regulation of ECs. In the present review, we discuss the role of miRNAs in various aspects of EC pathology in cardiometabolic diseases like atherosclerosis, type 2 diabetes, obesity, and the metabolic syndrome, and in complication of those pathologies, like ischemia. We also discuss the potential therapeutic applications of miRNAs in promoting angiogenesis and neovascularization in tissues where the endothelium is damaged in different cardiometabolic diseases. This article is part of a Special Issue entitled: MicroRNAs and lipid/energy metabolism and related diseases edited by Carlos Fernandez-Hernando and Yajaira Suarez. (C) 2016 Elsevier B.V. All rights reserved.
C1 Yale Univ, Sch Med, Program Integrat Cell Signaling & Neurobiol Metab, Sect Comparat Med,Dept Pathol, 10 Amistad St,Amistad Res Bldg 301-B, New Haven, CT 06520 USA.
   Yale Univ, Sch Med, Vasc Biol & Therapeut Program, 10 Amistad St,Amistad Res Bldg 301-B, New Haven, CT 06520 USA.
C3 Yale University; Yale University
RP Suarez, Y (corresponding author), Yale Univ, Sch Med, 10 Amistad St,Amistad Res Bldg 301-B, New Haven, CT 06520 USA.
EM yajaira.suarez@yale.edu
RI Araldi, Elisa/AAZ-5946-2021
OI Suarez, Yajaira/0000-0003-4549-2953; Araldi, Elisa/0000-0002-6596-6784
FU National Institutes of Health [R01HL105945]; American Heart Association
   [16GRNT26420047]; American Heart Association (AHA) [16GRNT26420047]
   Funding Source: American Heart Association (AHA)
FX The authors apologize to the many scientists whose contributions to the
   field could not be acknowledged owing to space limitations. YS
   laboratory is supported by grants from the National Institutes of Health
   (R01HL105945) and the American Heart Association (16GRNT26420047).
CR Aiello LP, 1997, OPHTHALMIC RES, V29, P354, DOI 10.1159/000268033
   Ambros V, 2004, NATURE, V431, P350, DOI 10.1038/nature02871
   [Anonymous], INT J VASC MED
   [Anonymous], 2015, GLOB STAT REP NONC D
   Araldi E, 2015, CURR VASC PHARMACOL, V13, P291, DOI 10.2174/15701611113119990012
   Atkins GB, 2007, CIRC RES, V100, P1686, DOI 10.1161/01.RES.0000267856.00713.0a
   Avogaro A, 2005, CLIN CHIM ACTA, V360, P9, DOI 10.1016/j.cccn.2005.04.020
   Bao MH, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0106540
   Bartel DP, 2009, CELL, V136, P215, DOI 10.1016/j.cell.2009.01.002
   Böhm F, 2007, CARDIOVASC RES, V76, P8, DOI 10.1016/j.cardiores.2007.06.004
   Bommer GT, 2007, CURR BIOL, V17, P1298, DOI 10.1016/j.cub.2007.06.068
   Bonauer A, 2009, SCIENCE, V324, P1710, DOI 10.1126/science.1174381
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Caporali A, 2011, CIRCULATION, V123, P282, DOI 10.1161/CIRCULATIONAHA.110.952325
   Carmeliet P, 2005, NATURE, V438, P932, DOI 10.1038/nature04478
   Cersosimo E, 2006, DIABETES-METAB RES, V22, P423, DOI 10.1002/dmrr.634
   Chamorro-Jorganes A., 2015, CIRCULATION RES
   Chamorro-Jorganes A, 2014, J CELL SCI, V127, P1169, DOI 10.1242/jcs.130518
   Chamorro-Jorganes A, 2013, PHARMACOL RES, V75, P15, DOI 10.1016/j.phrs.2013.04.002
   Chamorro-Jorganes A, 2011, ARTERIOSCL THROM VAS, V31, P2595, DOI 10.1161/ATVBAHA.111.236521
   Chen KC, 2011, J CELL SCI, V124, P4115, DOI 10.1242/jcs.092767
   Chen LJ, 2015, CIRC RES, V116, P1157, DOI 10.1161/CIRCRESAHA.116.305987
   Chen T, 2009, CARDIOVASC RES, V83, P131, DOI 10.1093/cvr/cvp121
   Cheng HS, 2013, EMBO MOL MED, V5, P1017, DOI 10.1002/emmm.201202318
   Cines DB, 1998, BLOOD, V91, P3527
   Conserva F, 2013, J NEPHROL, V26, P811, DOI 10.5301/jn.5000262
   Cooper JA, 2005, ATHEROSCLEROSIS, V181, P93, DOI 10.1016/j.atherosclerosis.2004.12.026
   Cross MJ, 2001, TRENDS PHARMACOL SCI, V22, P201, DOI 10.1016/S0165-6147(00)01676-X
   Dai G, 2007, CIRC RES, V101, P723, DOI 10.1161/CIRCRESAHA.107.152942
   Dangwal S, 2014, ANNU REV PHARMACOL, V54, P185, DOI 10.1146/annurev-pharmtox-011613-135957
   Dangwal S, 2012, THROMB HAEMOSTASIS, V108, P599, DOI 10.1160/TH12-03-0211
   Daniel JM, 2014, CARDIOVASC RES, V103, P564, DOI 10.1093/cvr/cvu162
   Davignon J, 2004, CIRCULATION, V109, P27, DOI 10.1161/01.CIR.0000131515.03336.f8
   Davis S, 2006, NUCLEIC ACIDS RES, V34, P2294, DOI 10.1093/nar/gkl183
   Demolli S, 2015, J MOL CELL CARDIOL, V88, P111, DOI 10.1016/j.yjmcc.2015.10.009
   Dentelli P, 2010, ARTERIOSCL THROM VAS, V30, P1562, DOI 10.1161/ATVBAHA.110.206201
   Fan WD, 2015, J CELL SCI, V128, P70, DOI 10.1242/jcs.154252
   Fang Y, 2012, ARTERIOSCL THROM VAS, V32, P979, DOI 10.1161/ATVBAHA.111.244053
   Fang Y, 2010, P NATL ACAD SCI USA, V107, P13450, DOI 10.1073/pnas.1002120107
   Fasanaro P, 2008, J BIOL CHEM, V283, P15878, DOI 10.1074/jbc.M800731200
   Feng B, 2014, LIFE SCI, V118, P275, DOI 10.1016/j.lfs.2014.10.001
   Fichtlscherer S, 2011, ARTERIOSCL THROM VAS, V31, P2383, DOI 10.1161/ATVBAHA.111.226696
   Filipowicz W, 2008, NAT REV GENET, V9, P102, DOI 10.1038/nrg2290
   Fish JE, 2008, DEV CELL, V15, P272, DOI 10.1016/j.devcel.2008.07.008
   Fornoni A, 2005, CURR HYPERTENS REP, V7, P88, DOI 10.1007/s11906-005-0080-6
   Ghosh G, 2010, J CLIN INVEST, V120, P4141, DOI 10.1172/JCI42980
   Glass CK, 2001, CELL, V104, P503, DOI 10.1016/S0092-8674(01)00238-0
   Goligorsky MS, 2005, AM J PHYSIOL-RENAL, V288, pF871, DOI 10.1152/ajprenal.00333.2004
   Hanson M, 2005, HEART, V91, P864, DOI 10.1136/hrt.2004.047381
   HANSSON GK, 1983, AM J PATHOL, V112, P278
   Hergenreider E, 2012, NAT CELL BIOL, V14, P249, DOI 10.1038/ncb2441
   Hilgendorf I, 2015, ARTERIOSCL THROM VAS, V35, P272, DOI 10.1161/ATVBAHA.114.303565
   Hinkel R, 2013, CIRCULATION, V128, P1066, DOI 10.1161/CIRCULATIONAHA.113.001904
   Hu SJ, 2010, CIRCULATION, V122, pS124, DOI 10.1161/CIRCULATIONAHA.109.928424
   Huang YQ, 2014, BMC NEPHROL, V15, DOI 10.1186/1471-2369-15-142
   Iaconetti C, 2012, BASIC RES CARDIOL, V107, DOI 10.1007/s00395-012-0296-y
   Kahn BB, 2000, J CLIN INVEST, V106, P473, DOI 10.1172/JCI10842
   Kantharidis P, 2011, DIABETES, V60, P1832, DOI 10.2337/db11-0082
   Khan Zia Ali, 2003, Exp Diabesity Res, V4, P287, DOI 10.1155/EDR.2003.287
   Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213
   Kuhnert F, 2008, DEVELOPMENT, V135, P3989, DOI 10.1242/dev.029736
   Landskroner-Eiger S, 2015, P NATL ACAD SCI USA, V112, P12812, DOI 10.1073/pnas.1507094112
   Lia D, 2010, J HYPERTENS, V28, P1646, DOI 10.1097/HJH.0b013e32833a4922
   Liao YC, 2014, J AM COLL CARDIOL, V63, P1685, DOI 10.1016/j.jacc.2013.09.069
   Loyer X, 2014, CIRC RES, V114, P434, DOI 10.1161/CIRCRESAHA.114.302213
   Magenta A, 2011, CELL DEATH DIFFER, V18, P1628, DOI 10.1038/cdd.2011.42
   McArthur K, 2011, DIABETES, V60, P1314, DOI 10.2337/db10-1557
   Michiels C, 2003, J CELL PHYSIOL, V196, P430, DOI 10.1002/jcp.10333
   Moller DE, 2005, ANNU REV MED, V56, P45, DOI 10.1146/annurev.med.56.082103.104751
   Napoli C, 2000, FASEB J, V14, P1996, DOI 10.1096/fj.99-0986com
   Ni CW, 2011, AM J PHYSIOL-HEART C, V300, pH1762, DOI 10.1152/ajpheart.00829.2010
   Njock MS, 2015, BLOOD, V125, P3202, DOI 10.1182/blood-2014-11-611046
   O'Riordan E, 2005, KIDNEY INT, V67, P1654, DOI 10.1111/j.1523-1755.2005.00256.x
   Ottosen S, 2015, ANTIMICROB AGENTS CH, V59, P599, DOI 10.1128/AAC.04220-14
   Panieri E, 2015, CELL MOL LIFE SCI, V72, P3281, DOI 10.1007/s00018-015-1928-9
   Parmar KM, 2006, J CLIN INVEST, V116, P49, DOI 10.1172/JCI24787
   Pearson JD, 2000, LUPUS, V9, P183, DOI 10.1191/096120300678828299
   POBER JS, 1990, TRANSPLANTATION, V50, P537, DOI 10.1097/00007890-199010000-00001
   Poliseno L, 2006, BLOOD, V108, P3068, DOI 10.1182/blood-2006-01-012369
   Pushparaj PN, 2008, J DENT RES, V87, P992, DOI 10.1177/154405910808701109
   Qin B, 2011, BIOCHEM BIOPH RES CO, V410, P127, DOI 10.1016/j.bbrc.2011.05.118
   Qin XM, 2010, P NATL ACAD SCI USA, V107, P3240, DOI 10.1073/pnas.0914882107
   Roberts LD, 2013, CELL METAB, V18, P43, DOI 10.1016/j.cmet.2013.05.009
   Sakao S, 2005, FASEB J, V19, P1178, DOI 10.1096/fj.04-3261fje
   Schober A, 2014, NAT MED, V20, P368, DOI 10.1038/nm.3487
   Schober A, 2012, THROMB HAEMOSTASIS, V107, P603, DOI 10.1160/TH12-02-0122
   Semo J, 2014, EUR HEART J, V35, P3212, DOI 10.1093/eurheartj/eht041
   Shilo S, 2008, ARTERIOSCL THROM VAS, V28, P471, DOI 10.1161/ATVBAHA.107.160655
   Son DJ, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms4000
   Soutschek J, 2004, NATURE, V432, P173, DOI 10.1038/nature03121
   STERN MP, 1995, DIABETES, V44, P369, DOI 10.2337/diabetes.44.4.369
   Suárez Y, 2008, P NATL ACAD SCI USA, V105, P14082, DOI 10.1073/pnas.0804597105
   Suárez Y, 2007, CIRC RES, V100, P1164, DOI 10.1161/01.RES.0000265065.26744.17
   Suárez Y, 2010, J IMMUNOL, V184, P21, DOI 10.4049/jimmunol.0902369
   Sumpio BE, 2002, INT J BIOCHEM CELL B, V34, P1508, DOI 10.1016/S1357-2725(02)00075-4
   Sun HX, 2012, HYPERTENSION, V60, P1407, DOI 10.1161/HYPERTENSIONAHA.112.197301
   Sun XH, 2014, CIRC RES, V114, P32, DOI 10.1161/CIRCRESAHA.113.302089
   Sun XH, 2012, J CLIN INVEST, V122, P1973, DOI 10.1172/JCI61495
   Tardy Y, 1997, ARTERIOSCL THROM VAS, V17, P3102, DOI 10.1161/01.ATV.17.11.3102
   Thompson RC, 2013, LANCET, V381, P1211, DOI 10.1016/S0140-6736(13)60598-X
   Thum T, 2012, CARDIOVASC RES, V93, P543, DOI 10.1093/cvr/cvs085
   van Solingen C, 2015, CURR VASC PHARMACOL, V13, P341
   van Solingen C, 2011, CARDIOVASC RES, V92, P449, DOI 10.1093/cvr/cvr227
   van Solingen C, 2009, J CELL MOL MED, V13, P1577, DOI 10.1111/j.1582-4934.2008.00613.x
   Verma S, 2003, CIRCULATION, V108, P2054, DOI 10.1161/01.CIR.0000089191.72957.ED
   Wang KC, 2014, ARTERIOSCL THROM VAS, V34, P1437, DOI 10.1161/ATVBAHA.114.303473
   Wang KC, 2010, P NATL ACAD SCI USA, V107, P3234, DOI 10.1073/pnas.0914825107
   Wang SS, 2008, DEV CELL, V15, P261, DOI 10.1016/j.devcel.2008.07.002
   Warboys CM, 2014, ARTERIOSCL THROM VAS, V34, P985, DOI 10.1161/ATVBAHA.114.303415
   Weber M, 2010, BIOCHEM BIOPH RES CO, V393, P643, DOI 10.1016/j.bbrc.2010.02.045
   Wu W, 2011, CIRCULATION, V124, P633, DOI 10.1161/CIRCULATIONAHA.110.005108
   YANAGISAWA M, 1988, NATURE, V332, P411, DOI 10.1038/332411a0
   Young A, 2009, ARTERIOSCL THROM VAS, V29, P1902, DOI 10.1161/ATVBAHA.109.193540
   Zaccagnini G, 2014, ANTIOXID REDOX SIGN, V21, P1177, DOI 10.1089/ars.2013.5206
   Zakkar M, 2009, ARTERIOSCL THROM VAS, V29, P1851, DOI 10.1161/ATVBAHA.109.193375
   Zhou J, 2011, P NATL ACAD SCI USA, V108, P10355, DOI 10.1073/pnas.1107052108
NR 116
TC 43
Z9 45
U1 1
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1388-1981
EI 1879-2618
J9 BBA-MOL CELL BIOL L
JI Biochim. Biophys. Acta Mol. Cell Biol. Lipids
PD DEC
PY 2016
VL 1861
IS 12
SI SI
BP 2094
EP 2103
DI 10.1016/j.bbalip.2016.01.013
PN B
PG 10
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA ED0QD
UT WOS:000388546100009
PM 26825686
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Garay-Sevilla, ME
   Beeri, MS
   de la Maza, MP
   Rojas, A
   Salazar-Villanea, S
   Uribarri, J
AF Garay-Sevilla, M. E.
   Beeri, M. S.
   de la Maza, M. P.
   Rojas, A.
   Salazar-Villanea, S.
   Uribarri, J.
TI The potential role of dietary advanced glycation endproducts in the
   development of chronic non-infectious diseases: a narrative review
SO NUTRITION RESEARCH REVIEWS
LA English
DT Review
DE Glycation; Oxidative stress; Diabetes; Metabolic syndrome; CVD;
   Dementia; Sarcopenia
ID OXIDATION PROTEIN PRODUCTS; NF-KAPPA-B; CACO-2 CELL MONOLAYERS;
   END-PRODUCTS; ALZHEIMERS-DISEASE; ENDOTHELIAL FUNCTION; METABOLIC
   SYNDROME; DIABETES-MELLITUS; OXIDANT STRESS; EPSILON-CARBOXYMETHYLLYSINE
AB Increasing clinical and experimental evidence accumulated during the past few decades supports an important role for dietary advanced glycation endproducts (AGE) in the pathogenesis of many chronic non-infectious diseases, such as type 2 diabetes, CVD and others, that are reaching epidemic proportions in the Western world. Although AGE are compounds widely recognised as generated in excess in the body in diabetic patients, the potential importance of exogenous AGE, mostly of dietary origin, has been largely ignored in the general nutrition audience. In the present review we aim to describe dietary AGE, their mechanisms of formation and absorption into the body as well as their main mechanisms of action. We will present in detail current evidence of their potential role in the development of several chronic non-infectious clinical conditions, some general suggestions on how to restrict them in the diet and evidence regarding the potential benefits of lowering their consumption.
C1 [Garay-Sevilla, M. E.] Univ Guanajuato, Med Sci Dept, Guanajuato, Mexico.
   [Beeri, M. S.] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
   [Beeri, M. S.] Sheba Med Ctr, Joseph Sagol Neurosci Ctr, Ramat Gan, Israel.
   [de la Maza, M. P.] Univ Chile, Inst Nutr & Food Technol Dr Fernando Monckeberg B, Santiago, Chile.
   [Rojas, A.] Catholic Univ Maule, Fac Med, Biomed Res Labs, Talca, Chile.
   [Salazar-Villanea, S.] Univ Costa Rica, Dept Anim Sci, San Jose, Costa Rica.
   [Uribarri, J.] Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA.
C3 Universidad de Guanajuato; Icahn School of Medicine at Mount Sinai;
   Chaim Sheba Medical Center; Tel Aviv University; Universidad de Chile;
   Universidad Catolica del Maule; Universidad Costa Rica; Icahn School of
   Medicine at Mount Sinai
RP Uribarri, J (corresponding author), Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA.
EM Jaime.uribarri@mountsinai.org
RI Uribarri, Jaime/ADX-7655-2022; Rojas, Armando/D-2647-2014
OI uribarri, jaime/0000-0001-9826-1134; Garay-Sevilla, Ma.
   Eugenia/0000-0002-6758-3197; Rojas, Armando/0000-0001-9911-7142; Salazar
   Villanea, Sergio/0000-0002-0332-6263
CR Abe R, 2008, CURR PHARM DESIGN, V14, P940, DOI 10.2174/138161208784139765
   Acevedo A, 2018, FREE RADICAL BIO MED, V116, P101, DOI 10.1016/j.freeradbiomed.2018.01.008
   Ahmad S, 2018, SEMIN CANCER BIOL, V49, P29, DOI 10.1016/j.semcancer.2017.10.005
   Ahmed N, 2005, J NEUROCHEM, V92, P255, DOI 10.1111/j.1471-4159.2004.02864.x
   Alleyn M, 2019, J CELL COMMUN SIGNAL, V13, P119, DOI 10.1007/s12079-018-0474-2
   Anderson MM, 2003, DIABETES, V52, P2137, DOI 10.2337/diabetes.52.8.2137
   Anderson MM, 1999, J CLIN INVEST, V104, P103, DOI 10.1172/JCI3042
   [Anonymous], 2019, QUALITY MANAGEMENT, V11, pS1007
   [Anonymous], 2017, DIABETOLOGIE STOF S2, V12, pS94, DOI 10.1055/s-0043-115953
   Aragno M, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040385
   Arvanitakis Z, 1999, REV NEUROL-FRANCE, V155, P113
   Assar SH, 2009, AMINO ACIDS, V36, P317, DOI 10.1007/s00726-008-0071-4
   Bains Y, 2017, FITOTERAPIA, V120, P1, DOI 10.1016/j.fitote.2017.05.003
   Bär KJ, 2003, NEUROBIOL AGING, V24, P333, DOI 10.1016/S0197-4580(02)00086-6
   Baye E, 2017, SCI REP, V7, P43, DOI [10.1038/s41598-017-00119-6, DOI 10.1038/S41598-017-00119-6]
   Baye E, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-04214-6
   Bierhaus A, 2001, DIABETES, V50, P2792, DOI 10.2337/diabetes.50.12.2792
   Birlouez-Aragon I, 2010, AM J CLIN NUTR, V91, P1220, DOI 10.3945/ajcn.2009.28737
   Blaser H, 2016, TRENDS CELL BIOL, V26, P249, DOI 10.1016/j.tcb.2015.12.002
   Buelna-Chontal M, 2013, CELL SIGNAL, V25, P2548, DOI 10.1016/j.cellsig.2013.08.007
   Cai WJ, 2007, AM J PATHOL, V170, P1893, DOI 10.2353/ajpath.2007.061281
   Cai WJ, 2014, P NATL ACAD SCI USA, V111, P4940, DOI 10.1073/pnas.1316013111
   Cai WJ, 2012, P NATL ACAD SCI USA, V109, P15888, DOI 10.1073/pnas.1205847109
   Cao W, 2014, KIDNEY INT SUPPL, V4, P102, DOI 10.1038/kisup.2014.19
   Cerami C, 1997, P NATL ACAD SCI USA, V94, P13915, DOI 10.1073/pnas.94.25.13915
   Chen YJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0066611
   Cheng A, 2013, INT J BIOL SCI, V9, P94, DOI 10.7150/ijbs.5246
   Coughlan MT, 2009, J AM SOC NEPHROL, V20, P742, DOI 10.1681/ASN.2008050514
   Cristani M, 2016, CURR MED CHEM, V23, P3862, DOI 10.2174/0929867323666160902154748
   Cruz-Jentoft AJ, 2019, AGE AGEING, V48, P16, DOI 10.1093/ageing/afy169
   Dalal M, 2009, J GERONTOL A-BIOL, V64, P132, DOI 10.1093/gerona/gln018
   Davis KE, 2015, BRIT J NUTR, V114, P1797, DOI 10.1017/S0007114515003487
   de Courten B, 2016, AM J CLIN NUTR, V103, P1426, DOI 10.3945/ajcn.115.125427
   DeChristopher LR, 2016, NUTR DIABETES, V6, DOI 10.1038/nutd.2016.46
   Di Pino A, 2016, J CLIN LIPIDOL, V10, P1098, DOI 10.1016/j.jacl.2016.07.001
   Drenth H, 2016, EUR REV AGING PHYS A, V13, DOI 10.1186/s11556-016-0163-1
   Eguchi Y, 2018, EUR SPINE J, V27, P597, DOI 10.1007/s00586-017-5370-6
   Elnakish MT, 2013, J PATHOL, V231, P290, DOI 10.1002/path.4255
   Forrester SJ, 2018, CIRC RES, V122, P877, DOI 10.1161/CIRCRESAHA.117.311401
   Förster A, 2005, ANN NY ACAD SCI, V1043, P474, DOI 10.1196/annals.1333.054
   Geissler S, 2010, J AGR FOOD CHEM, V58, P2543, DOI 10.1021/jf903791u
   Gironés X, 2004, FREE RADICAL BIO MED, V36, P1241, DOI 10.1016/j.freeradbiomed.2004.02.006
   Gloire G, 2006, BIOCHEM PHARMACOL, V72, P1493, DOI 10.1016/j.bcp.2006.04.011
   Gloire G, 2009, ANTIOXID REDOX SIGN, V11, P2209, DOI [10.1089/ars.2009.2463, 10.1089/ARS.2009.2463]
   Goldberg T, 2004, J AM DIET ASSOC, V104, P1287, DOI 10.1016/j.jada.2004.05.214
   González I, 2013, IMMUNOBIOLOGY, V218, P790, DOI 10.1016/j.imbio.2012.09.005
   Grunwald S, 2006, BRIT J NUTR, V95, P1221, DOI 10.1079/BJN20061793
   Gugliucci A, 2009, ANN NUTR METAB, V54, P197, DOI 10.1159/000217817
   Guo JC, 2008, J AM SOC NEPHROL, V19, P961, DOI 10.1681/ASN.2007101109
   Guo ZJ, 2008, ANTIOXID REDOX SIGN, V10, P1699, DOI 10.1089/ars.2007.1999
   Macías-Cervantes MH, 2015, NUTRITION, V31, P446, DOI 10.1016/j.nut.2014.10.004
   Haus JM, 2007, J APPL PHYSIOL, V103, P2068, DOI 10.1152/japplphysiol.00670.2007
   Hellwig M, 2019, J AGR FOOD CHEM, V67, P1963, DOI 10.1021/acs.jafc.8b06748
   Hellwig M, 2014, AMINO ACIDS, V46, P289, DOI 10.1007/s00726-013-1501-5
   Hellwig M, 2011, CHEMBIOCHEM, V12, P1270, DOI 10.1002/cbic.201000759
   Hellwig M, 2009, J AGR FOOD CHEM, V57, P6474, DOI 10.1021/jf901224p
   Henning RJ, 2018, FUTUR CARDIOL, V14, DOI 10.2217/fca-2018-0045
   Hoffmann MH, 2018, FREE RADICAL BIO MED, V125, P62, DOI 10.1016/j.freeradbiomed.2018.03.016
   Hofmann MA, 1999, CELL, V97, P889, DOI 10.1111/j.1365-2222.2011.03714.x
   Hordijk PL, 2006, CIRC RES, V98, P453, DOI 10.1161/01.RES.0000204727.46710.5e
   Hudson BI, 2018, ANNU REV MED, V69, P349, DOI 10.1146/annurev-med-041316-085215
   Hudson BI, 2011, ATHEROSCLEROSIS, V216, P192, DOI 10.1016/j.atherosclerosis.2011.01.024
   Hudson BI, 2008, J BIOL CHEM, V283, P34457, DOI 10.1074/jbc.M801465200
   Iwashige Kenichi, 2004, Journal of Physiological Anthropology and Applied Human Science, V23, P19, DOI 10.2114/jpa.23.19
   Kato M, 2017, GERIATR GERONTOL INT, V17, P785, DOI 10.1111/ggi.12787
   Kellow NJ, 2015, NUTR REV, V73, P737, DOI 10.1093/nutrit/nuv030
   Kierdorf K, 2013, J LEUKOCYTE BIOL, V94, P55, DOI 10.1189/jlb.1012519
   Koschinsky T, 1997, P NATL ACAD SCI USA, V94, P6474, DOI 10.1073/pnas.94.12.6474
   Li Y, 2017, FREE RADICAL BIO MED, V109, P33, DOI 10.1016/j.freeradbiomed.2017.02.049
   Lin JA, 2018, J AGR FOOD CHEM, V66, P2065, DOI 10.1021/acs.jafc.7b05943
   Liu ZW, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00477
   Lopez-Moreno J, 2016, J AM GERIATR SOC, V64, P901, DOI 10.1111/jgs.14062
   Luévano-Contreras C, 2013, J CLIN BIOCHEM NUTR, V52, P22, DOI 10.3164/jcbn.12-40
   Lüth HJ, 2005, CEREB CORTEX, V15, P211, DOI 10.1093/cercor/bhh123
   Rodriguez JM, 2015, NUTR HOSP, V31, P2511, DOI 10.3305/nh.2015.31.6.8936
   Mark AB, 2014, DIABETES CARE, V37, P88, DOI 10.2337/dc13-0842
   Martinez-Saez N, 2019, FOOD RES INT, V118, P72, DOI 10.1016/j.foodres.2017.09.056
   Meli M, 2002, J ALZHEIMERS DIS, V4, P93, DOI 10.3233/JAD-2002-4203
   MIKI S, 1993, BIOCHEM BIOPH RES CO, V196, P984, DOI 10.1006/bbrc.1993.2346
   Moran C, 2015, DIABETES, V64, P279, DOI 10.2337/db14-0506
   Mori H, 2017, J DIABETES INVEST, V8, P377, DOI 10.1111/jdi.12582
   Negrean M, 2007, AM J CLIN NUTR, V85, P1236, DOI 10.1093/ajcn/85.5.1236
   OBRIEN J, 1989, CRIT REV FOOD SCI, V28, P211, DOI 10.1080/10408398909527499
   Ott C, 2014, REDOX BIOL, V2, P411, DOI 10.1016/j.redox.2013.12.016
   Palanissami G, 2018, HORM CANCER-US, V9, P295, DOI 10.1007/s12672-018-0342-9
   Petry A, 2010, ANTIOXID REDOX SIGN, V13, P467, DOI 10.1089/ars.2009.3026
   Raman KG, 2006, AM J PHYSIOL-GASTR L, V291, pG556, DOI 10.1152/ajpgi.00055.2006
   Ramasamy R, 2016, EXPERT OPIN THER TAR, V20, P431, DOI 10.1517/14728222.2016.1111873
   Raucci A, 2008, FASEB J, V22, P3716, DOI 10.1096/fj.08-109033
   Reynaert NL, 2016, INT J BIOCHEM CELL B, V81, P403, DOI 10.1016/j.biocel.2016.06.016
   Riehl A, 2009, CELL COMMUN SIGNAL, V7, DOI 10.1186/1478-811X-7-12
   Roglic G, 2016, Global report on psoriasis
   Rojas A., 2018, DIETARY AGES THEIR R, P37, DOI [10.1201/9781315120041-4, DOI 10.1201/9781315120041-4]
   Rojas A, 2018, CARCINOGENESIS, V39, P515, DOI 10.1093/carcin/bgy012
   Rojas A, 2013, CELL SIGNAL, V25, P609, DOI 10.1016/j.cellsig.2012.11.022
   Rojas A, 2010, CARCINOGENESIS, V31, P334, DOI 10.1093/carcin/bgp322
   ROSENBERG IH, 1995, ANN INTERN MED, V123, P727, DOI 10.7326/0003-4819-123-9-199511010-00014
   Sakaguchi M, 2014, J BIOL CHEM, V289, P23389, DOI 10.1074/jbc.M114.573071
   Sakaguchi M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023132
   Salazar-Villanea S, 2017, J AM OIL CHEM SOC, V94, P619, DOI 10.1007/s11746-017-2960-8
   Salazar-Villanea S, 2016, J ANIM SCI BIOTECHNO, V7, DOI 10.1186/s40104-016-0120-x
   Santilli F, 2009, CURR MED CHEM, V16, P940, DOI 10.2174/092986709787581888
   Sasaki N, 1998, AM J PATHOL, V153, P1149, DOI 10.1016/S0002-9440(10)65659-3
   Scheijen JLJM, 2016, FOOD CHEM, V190, P1145, DOI 10.1016/j.foodchem.2015.06.049
   Schiekofer S, 2006, EXP CLIN ENDOCR DIAB, V114, P160, DOI 10.1055/s-2006-924081
   Seiquer I, 2014, MOL NUTR FOOD RES, V58, P1552, DOI 10.1002/mnfr.201300847
   Semba RD, 2014, J NUTR, V144, P1037, DOI 10.3945/jn.113.189480
   Sharma C, 2015, J FOOD SCI TECH MYS, V52, P7561, DOI 10.1007/s13197-015-1851-y
   Stirban A, 2008, ANN NY ACAD SCI, V1126, P276, DOI 10.1196/annals.1433.042
   Stirban A, 2006, DIABETES CARE, V29, P2064, DOI 10.2337/dc06-0531
   Su GY, 2018, RSC ADV, V8, P35870, DOI 10.1039/c8ra02585a
   Takeda A, 2001, ACTA NEUROPATHOL, V101, P27
   The Lancet Haematology, 2018, LANCET HAEMATOL, V5, pe127
   Thome J, 1996, LIFE SCI, V59, P679, DOI 10.1016/0024-3205(96)00349-9
   Turner DP, 2017, ADV CANCER RES, V133, P1, DOI 10.1016/bs.acr.2016.08.001
   Turner RC, 1998, BMJ-BRIT MED J, V316, P823, DOI 10.1136/bmj.316.7134.823
   Uribarri J, 2003, J AM SOC NEPHROL, V14, P728, DOI 10.1097/01.ASN.0000051593.41395.B9
   Uribarri J, 2007, DIABETES CARE, V30, P2579, DOI 10.2337/dc07-0320
   Uribarri J, 2015, ADV NUTR, V6, P461, DOI 10.3945/an.115.008433
   Uribarri J, 2011, DIABETES CARE, V34, P1610, DOI 10.2337/dc11-0091
   Uribarri J, 2010, J AM DIET ASSOC, V110, P911, DOI 10.1016/j.jada.2010.03.018
   Vaziri ND, 2016, NEPHROL DIAL TRANSPL, V31, P737, DOI 10.1093/ndt/gfv095
   Vistoli G, 2013, FREE RADICAL RES, V47, P3, DOI 10.3109/10715762.2013.815348
   VITEK MP, 1994, P NATL ACAD SCI USA, V91, P4766, DOI 10.1073/pnas.91.11.4766
   Vlassara H, 2002, P NATL ACAD SCI USA, V99, P15596, DOI 10.1073/pnas.242407999
   Vlassara H, 2016, DIABETOLOGIA, V59, P2181, DOI 10.1007/s00125-016-4053-x
   Vlassara H, 2014, CURR DIABETES REP, V14, DOI 10.1007/s11892-013-0453-1
   Vlassara H, 2009, KIDNEY INT, V76, pS3, DOI 10.1038/ki.2009.401
   Vlassara H, 2009, J CLIN ENDOCR METAB, V94, P4483, DOI 10.1210/jc.2009-0089
   Walter KR, 2019, BREAST CANCER RES TR, V173, P559, DOI 10.1007/s10549-018-4992-7
   WAUTIER JL, 1994, P NATL ACAD SCI USA, V91, P7742, DOI 10.1073/pnas.91.16.7742
   Wautier MP, 2017, DIABETES METAB SYND, V11, P305, DOI 10.1016/j.dsx.2016.09.009
   West RK, 2014, MECH AGEING DEV, V140, P10, DOI 10.1016/j.mad.2014.07.001
   Witko-Sarsat V, 1998, J IMMUNOL, V161, P2524
   WitkoSarsat V, 1996, KIDNEY INT, V49, P1304, DOI 10.1038/ki.1996.186
   Wu Q, 2016, APOPTOSIS, V21, P36, DOI 10.1007/s10495-015-1191-4
   Yaffe K, 2011, NEUROLOGY, V77, P1351, DOI 10.1212/WNL.0b013e3182315a56
   Yamamoto Y, 2012, KIDNEY INT, V82, P733, DOI 10.1038/ki.2012.163
   YAN SD, 1994, P NATL ACAD SCI USA, V91, P7787, DOI 10.1073/pnas.91.16.7787
   YAN SD, 1994, J BIOL CHEM, V269, P9889
   Yan SD, 1996, NATURE, V382, P685, DOI 10.1038/382685a0
   Yan SF, 2008, NAT CLIN PRACT ENDOC, V4, P285, DOI 10.1038/ncpendmet0786
   Young KG, 2010, BBA-MOL CELL RES, V1803, P183, DOI 10.1016/j.bbamcr.2008.09.017
   Zhang JX, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/4350965
   Zhang L, 2008, J BIOL CHEM, V283, P35507, DOI 10.1074/jbc.M806948200
   Zhao D, 2017, FOOD RES INT, V102, P313, DOI 10.1016/j.foodres.2017.10.002
   Zhao D, 2017, J AGR FOOD CHEM, V65, P5778, DOI 10.1021/acs.jafc.7b01951
   Zhou LL, 2012, KIDNEY INT, V82, P759, DOI 10.1038/ki.2012.184
   2008, AM J PHYSL, V294, pC145
NR 149
TC 36
Z9 37
U1 1
U2 38
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0954-4224
EI 1475-2700
J9 NUTR RES REV
JI Nutr. Res. Rev.
PD DEC
PY 2020
VL 33
IS 2
BP 298
EP 311
AR PII S0954422420000104
DI 10.1017/S0954422420000104
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OO9FQ
UT WOS:000587679400009
PM 32238213
DA 2025-06-11
ER

PT J
AU Benberin, VV
   Sibagatova, AS
   Nagimtayeva, AA
   Akhmetova, KM
   Voshchenkova, TA
AF Benberin, Valery V.
   Sibagatova, Ainur S.
   Nagimtayeva, Almagul A.
   Akhmetova, Kamshat M.
   Voshchenkova, Tamara A.
TI RETRACTED: Systematisation of biological protectors for managing the
   metabolic syndrome development (Retracted article. See MAY, 2023)
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Article; Retracted Publication
DE Bioprotectors; Homeostasis; Cardiometabolic diseases; Regulation of
   homeostasis
ID HOMEOSTASIS
AB Background Metabolic syndrome (MS) is becoming a major health risk in the world. Disorders of homeostasis are a trigger for MS and subsequent cardiometabolic diseases (CMDs). Its physiological role can be supported by biological protectors (BP). The purpose of this study is to develop a BP system for managing the MS development. Methods Within the framework of the case-control study, 3000 participants aged 20-60 years formed 2 groups: the main group and the control group. Results The study compared traditional markers of oxidative stress, chronic inflammation, and insulin resistance, which reflect the state of homeostasis. The BP system, proposed based on the concept of maintaining homeostasis, offers the following points for investigating the possibilities of therapeutic intervention: confronting dysregulation of homeostasis, resisting chronic inflammation and oxidative stress, resisting the consequences of disturbed homeostasis. This approach not only contributed to the understanding of general biological processes, but also provided a targeted search and development of BP to maintain the stability of homeostasis with MS. Conclusions The study results provided insight into new opportunities in the MS management.
C1 [Benberin, Valery V.] Med Ctr Hosp Presidents Affairs Adm Republ Kazakh, Adm Dept, 80 Mangilik El Ave, Nur Sultan 010000, Kazakhstan.
   [Sibagatova, Ainur S.] Med Ctr Hosp Presidents Affairs Adm Republ Kazakh, Sect Clin Res, 80 Mangilik El Ave, Nur Sultan 010000, Kazakhstan.
   [Nagimtayeva, Almagul A.; Akhmetova, Kamshat M.; Voshchenkova, Tamara A.] Med Ctr Hosp Presidents Affairs Adm Republ Kazakh, Gerontol Ctr, 80 Mangilik El Ave, Nur Sultan 010000, Kazakhstan.
RP Benberin, VV (corresponding author), Med Ctr Hosp Presidents Affairs Adm Republ Kazakh, Adm Dept, 80 Mangilik El Ave, Nur Sultan 010000, Kazakhstan.
EM benberin5892@kpi.com.de
FU Committee of Science under the Ministry of Education and Science of the
   Republic of Kazakhstan [BR05236375]
FX The study was carried out within the framework of the technological
   programme BR05236375 "Study of the features concerning genetic risk of
   diseases associated with metabolic syndrome in the Kazakh population, by
   order of the State Institution " Committee of Science under the Ministry
   of Education and Science of the Republic of Kazakhstan".
CR Aleksandrova K, 2018, CLIN CHEM, V64, P142, DOI 10.1373/clinchem.2017.275172
   Aliper A, 2017, AGING-US, V9, P2245, DOI 10.18632/aging.101319
   Armani A, 2017, FASEB J, V31, P4240, DOI 10.1096/fj.201601125RRR
   Carnagarin R, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1069-2
   Chala Inna, 2021, Scientific Horizons, V24, P14, DOI 10.48077/scihor.24(1).2021.14-21
   Czech MP, 2020, MOL METAB, V34, P27, DOI 10.1016/j.molmet.2019.12.014
   Emanuelli B, 2008, P NATL ACAD SCI USA, V105, P3545, DOI 10.1073/pnas.0712275105
   Fatima N, 2020, PFLUG ARCH EUR J PHY, V472, P513, DOI 10.1007/s00424-020-02381-6
   Figueira I, 2016, MECH AGEING DEV, V160, P69, DOI 10.1016/j.mad.2016.09.009
   Flaa A, 2008, METABOLISM, V57, P1422, DOI 10.1016/j.metabol.2008.05.012
   Goyal A, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-124
   Kim EC, 2019, BMB REP, V52, P47
   Kim J, 2018, MOL CELLS, V41, P11, DOI 10.14348/molcells.2018.2228
   Kotas ME, 2015, CELL, V160, P816, DOI 10.1016/j.cell.2015.02.010
   Kovalenko M., 2021, SCI HORIZONS, V24, P54
   Li SY, 2019, J TISSUE ENG REGEN M, V13, P143, DOI 10.1002/term.2775
   McMillen IC, 2005, PHYSIOL REV, V85, P571, DOI 10.1152/physrev.00053.2003
   Moskalev A, 2017, AGING DIS, V8, P354, DOI 10.14336/AD.2016.1022
   Nishiyama K, 2018, NEUROCHEM RES, V43, P19, DOI 10.1007/s11064-017-2269-x
   Simmons RK, 2010, DIABETOLOGIA, V53, P600, DOI 10.1007/s00125-009-1620-4
   Veen LV, 2020, NPJ DIGIT MED, V3, DOI 10.1038/s41746-020-0283-x
   Vona R, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8267234
   Yizhak K, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3632
NR 23
TC 1
Z9 1
U1 0
U2 2
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD DEC
PY 2021
VL 20
IS 2
BP 1449
EP 1454
DI 10.1007/s40200-021-00883-3
EA AUG 2021
PG 6
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA XE9GG
UT WOS:000691508000002
PM 34900796
OA Green Published
DA 2025-06-11
ER

PT J
AU Sferrazzo, G
   Palmeri, R
   Vanella, L
   Parafati, L
   Ronsisvalle, S
   Biondi, A
   Basile, F
   Li Volti, G
   Barbagallo, I
AF Sferrazzo, Giuseppe
   Palmeri, Rosa
   Vanella, Luca
   Parafati, Lucia
   Ronsisvalle, Simone
   Biondi, Antonio
   Basile, Francesco
   Li Volti, Giovanni
   Barbagallo, Ignazio
TI Mangifera indica L. Leaf Extract Induces Adiponectin and Regulates
   Adipogenesis
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE oxidative stress; metabolic syndrome; adipocyte; adiponectin; mangiferin
ID HIGH-FAT DIET; ADIPOSE-TISSUE; INSULIN SENSITIVITY; PPAR-GAMMA; OBESITY;
   MICE; MANGO; RESPONSES; HYPERLIPIDEMIA; CARDIOMYOPATHY
AB Natural bioactive compounds may be used in obese patients because of their ability to impact on various key mechanisms involved in the complex pathophysiological mechanisms of such condition. The aim of this study was to investigate the effect of a Mangifera indica L. leaf extract (MLE) on adipogenic differentiation of murine preadipocyte cells. 3T3-L1 cells were treated during their differentiation with various concentrations of (Mangifera indica L.) leaves extract (MLE) (750, 380, 150, 75 and 35 mu g) in order to assess their lipid content, adiponectin production, expression profile of genes involved in lipid metabolism, oxidative stress and inflammation. Our results showed that MLE was particularly enriched in polyphenols (46.30 +/- 0.083 mg/g) and that pharmacological treatment of cells resulted in a significant increase of adiponectin levels and reduction of intracellular lipid content. Consistently with these results, MLE resulted in a significant decrease of the expression of genes involved in lipid metabolism (FAS, PPARG, DGAT1, DGAT2, and SCD-1). In conclusion, our results suggest that MLE may represent a possible pharmacological tool for obese or metabolic syndrome patients.
C1 [Sferrazzo, Giuseppe; Vanella, Luca; Ronsisvalle, Simone; Barbagallo, Ignazio] Univ Catania, Dept Drug Sci, Biochem Sect, Viale A Doria 6, I-95125 Catania, Italy.
   [Palmeri, Rosa; Parafati, Lucia] Univ Catania, Dept Agr Food & Environm, Via S Sofia, I-95125 Catania, Italy.
   [Biondi, Antonio; Basile, Francesco] Univ Catania, Dept Gen Surg & Med Surg Specialties, Via S Sofia 87, I-95125 Catania, Italy.
   [Li Volti, Giovanni] Univ Catania, Dept Biomed & Biotechnol Sci, Via S Sofia 87, I-95125 Catania, Italy.
   [Li Volti, Giovanni] EuroMediterranean Inst Sci & Technol, Via Michele Miraglia 20, I-90139 Palermo, Italy.
C3 University of Catania; University of Catania; University of Catania;
   University of Catania
RP Li Volti, G (corresponding author), Univ Catania, Dept Biomed & Biotechnol Sci, Via S Sofia 87, I-95125 Catania, Italy.; Li Volti, G (corresponding author), EuroMediterranean Inst Sci & Technol, Via Michele Miraglia 20, I-90139 Palermo, Italy.
EM livolti@unict.it
RI parafati, lucia/ISB-1841-2023; Ronsisvalle, Simone/AAD-7995-2019; Volti,
   Giovanni/A-2435-2008; PALMERI, Rosa/AAK-6035-2020; Vanella,
   Luca/J-7354-2016; Biondi, Antonio/C-9190-2013
OI Vanella, Luca/0000-0002-6314-6029; Barbagallo,
   Ignazio/0000-0002-7761-0662; Basile, Francesco/0000-0001-6831-5840;
   PALMERI, Rosa/0000-0002-7660-5781; Parafati, Lucia/0000-0002-1228-4181;
   Li Volti, Giovanni/0000-0002-8678-2183; Biondi,
   Antonio/0000-0002-9374-779X
FU University of Catania
FX This work was supported by a grant from the University of Catania (FIR
   2016-2018, PI: Giovanni Li Volti).
CR Abdullah ASH, 2015, BMC COMPLEM ALTERN M, V15, DOI 10.1186/s12906-015-0575-x
   Achari AE, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18061321
   Aiello D, 2015, J PLANT PATHOL, V97, P273
   [Anonymous], EVID BASED COMPL ALT
   [Anonymous], BIOCH ADIPONECTIN
   Arita Y, 1999, BIOCHEM BIOPH RES CO, V257, P79, DOI 10.1006/bbrc.1999.0255
   Barbagallo I, 2014, CURR PHARM DESIGN, V20, P4970
   Beckman CH, 2000, PHYSIOL MOL PLANT P, V57, P101, DOI 10.1006/pmpp.2000.0287
   Burton-Freeman BM, 2017, FOOD FUNCT, V8, P3010, DOI [10.1039/c7fO00190h, 10.1039/c7fo00190h, 10.1039/C7FO00190H]
   Cao J, 2017, AM J PHYSIOL-HEART C, V313, pH368, DOI 10.1152/ajpheart.00093.2017
   Cao J, 2012, HYPERTENSION, V60, P467, DOI 10.1161/HYPERTENSIONAHA.112.193805
   Fried SK, 1998, J CLIN ENDOCR METAB, V83, P847, DOI 10.1210/jc.83.3.847
   Gazwi HSS, 2019, J PHARMACEUT BIOMED, V164, P112, DOI 10.1016/j.jpba.2018.10.027
   Guo FC, 2017, FOOD FUNCT, V8, P2455, DOI 10.1039/c7fo00081b
   Heimark D, 2014, ENDOCR J, V61, P111, DOI 10.1507/endocrj.EJ13-0423
   Hou J, 2013, CAN J PHYSIOL PHARM, V91, P759, DOI 10.1139/cjpp-2013-0090
   Hou NN, 2016, J MOL CELL CARDIOL, V99, P188, DOI 10.1016/j.yjmcc.2016.09.005
   Illesca P, 2019, BIOMED PHARMACOTHER, V109, P2472, DOI 10.1016/j.biopha.2018.11.120
   Kim JY, 2007, J CLIN INVEST, V117, P2621, DOI 10.1172/JCI31021
   Kozuka C, 2013, OBES RES CLIN PRACT, V7, pE165, DOI 10.1016/j.orcp.2013.02.003
   Li M, 2008, DIABETES, V57, P1526, DOI 10.2337/db07-1764
   Li SS, 2009, JAMA-J AM MED ASSOC, V302, P179, DOI 10.1001/jama.2009.976
   Ling LT, 2009, FOOD CHEM, V113, P1154, DOI 10.1016/j.foodchem.2008.09.004
   Liu X, 2015, EXP PHYSIOL, V100, P865, DOI 10.1113/EP085116
   Maeda N, 2002, NAT MED, V8, P731, DOI 10.1038/nm724
   Meneses MA, 2015, J FOOD ENG, V163, P45, DOI 10.1016/j.jfoodeng.2015.04.025
   Na LX, 2015, SCI REP-UK, V5, DOI 10.1038/srep10344
   Nawrocki AR, 2006, J BIOL CHEM, V281, P2654, DOI 10.1074/jbc.M505311200
   Niu YC, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030782
   Sellés AJN, 2015, CURR PHARM BIOTECHNO, V16, P272, DOI 10.2174/138920101603150202143532
   Ouchi N, 2003, CURR OPIN LIPIDOL, V14, P561, DOI 10.1097/00041433-200312000-00003
   Peng X, 2016, FOOD CHEM, V190, P207, DOI 10.1016/j.foodchem.2015.05.088
   Pokorski M, 2018, RESP PHYSIOL NEUROBI, V255, P30, DOI 10.1016/j.resp.2018.05.005
   Ramírez NM, 2017, BIOMED PHARMACOTHER, V91, P938, DOI 10.1016/j.biopha.2017.05.015
   Ronsisvalle S, 2019, NAT PROD RES, V33, P843, DOI 10.1080/14786419.2017.1413568
   Rosalie R, 2018, J PLANT PHYSIOL, V224, P75, DOI 10.1016/j.jplph.2018.03.011
   Rudich A, 1998, DIABETES, V47, P1562, DOI 10.2337/diabetes.47.10.1562
   Samaras K, 2010, OBESITY, V18, P884, DOI 10.1038/oby.2009.443
   Scalbert A, 2005, AM J CLIN NUTR, V81, p215S, DOI 10.1093/ajcn/81.1.215S
   Schieber A., 2000, Innovative Food Science & Emerging Technologies, V1, P161, DOI 10.1016/S1466-8564(00)00015-1
   Shokrpour M, 2019, GYNECOL ENDOCRINOL, V35, P406, DOI 10.1080/09513590.2018.1540570
   Toita R, 2016, BIOMATERIALS, V110, P81, DOI 10.1016/j.biomaterials.2016.09.018
   Tsuchida A, 2005, DIABETES, V54, P3358, DOI 10.2337/diabetes.54.12.3358
   Turer AT, 2012, DIABETOLOGIA, V55, P2319, DOI 10.1007/s00125-012-2598-x
   Unfer V, 2012, GYNECOL ENDOCRINOL, V28, P509, DOI 10.3109/09513590.2011.650660
   Vanella L, 2014, UROLOGY, V83, DOI 10.1016/j.urology.2014.03.007
   Vazquez Roncero A., 1973, Grasas y Aceites, V24, P350
   Yang L, 2018, MOLECULES, V23, DOI 10.3390/molecules23040762
   Zhang Y, 2013, FOOD CHEM, V141, P2896, DOI 10.1016/j.foodchem.2013.05.121
   Zhu JK, 2016, CELL, V167, P313, DOI 10.1016/j.cell.2016.08.029
NR 50
TC 13
Z9 13
U1 0
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL 1
PY 2019
VL 20
IS 13
AR 3211
DI 10.3390/ijms20133211
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA IL1EG
UT WOS:000477041100099
PM 31261958
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Rasgon, NL
   Kenna, HA
   Williams, KE
   Powers, B
   Wroolie, T
   Schatzberg, AF
AF Rasgon, Natalie L.
   Kenna, Heather A.
   Williams, Katherine E.
   Powers, Bevin
   Wroolie, Tonita
   Schatzberg, Alan F.
TI Rosiglitazone Add-On in Treatment of Depressed Patients with Insulin
   Resistance: a Pilot Study
SO THESCIENTIFICWORLDJOURNAL
LA English
DT Article
DE insulin resistance; depression; Matsuda Index; rosiglitazone
ID GLUCOSE-TOLERANCE; CARDIOVASCULAR-DISEASE; REPRODUCTIVE FUNCTION;
   AFFECTIVE-DISORDERS; METABOLIC SYNDROME; WOMEN; RISK; SENSITIVITY;
   SYMPTOMS
AB A number of cross-sectional studies have suggested an association between insulin resistance (IR) and affective disorders. However, limited data exist on potential changes in IR in a prospective treatment of depression. The present pilot study tested the hypothesis that improvement of IR with the addition of an insulin-sensitizing agent would improve mood in nondiabetic patients with unipolar or bipolar depression, who had surrogate blood markers suggestive of IR. Surrogate IR-criteria blood markers were fasting plasma glucose >100 mg/dl or triglyceride (TG) to high density lipoprotein (HDL) ratio >3.0. Open-label rosiglitazone, titrated to a dose of 8 mg/day, was administered for 12 weeks to 12 patients with depressive disorder receiving treatment as usual (TAU). Eight patients who completed the 12-week study exhibited significant declines in both depression severity by the Hamilton Depression Rating Scale and the Clinical Global Impression scale, with moderate effect sizes noted. Modest improvement in Matsuda Index scores was also noted at 12 weeks, yet declines in depression severity scores were not associated with improvements in the endocrine markers (Matsuda Index, TG/HDL ratio, and body mass index). These results suggest the potential novel use for an insulin-sensitizing agent in the treatment of depressive disorders. Larger placebocontrolled studies are warranted.
C1 [Rasgon, Natalie L.; Kenna, Heather A.; Williams, Katherine E.; Powers, Bevin; Wroolie, Tonita] Stanford Univ, Sch Med, Stanford Ctr Neurosci Womens Hlth, Stanford, CA 94305 USA.
   [Schatzberg, Alan F.] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Mood Disorders Program, Stanford, CA USA.
C3 Stanford University; Stanford University
RP Rasgon, NL (corresponding author), Stanford Univ, Sch Med, Stanford Ctr Neurosci Womens Hlth, Stanford, CA 94305 USA.
EM nrasgon@stanford.edu; hkenna@stanford.edu; elliew@stanford.edu;
   bnpowers@stanford.edu; twroolie@stanford.edu; afschatz@stanford.edu
RI Rasgon, Natalie/ABH-9813-2020
FU National Center for Research Resources, National Institutes of Health
   [M01 RR-00070]
FX This study was supported in part by grant M01 RR-00070 from the National
   Center for Research Resources, National Institutes of Health.
CR Abbasi F, 2008, AM J CARDIOL, V102, P64, DOI 10.1016/j.amjcard.2008.02.097
   Amer Diabet Assoc, 2008, DIABETES CARE, V31, pS12, DOI 10.2337/dc08-S012
   CASPER RC, 1977, PSYCHONEUROENDOCRINO, V2, P105, DOI 10.1016/0306-4530(77)90016-6
   Chiba M, 2000, METABOLISM, V49, P1145, DOI 10.1053/meta.2000.8611
   Cleland JGF, 2007, LANCET, V370, P1103, DOI 10.1016/S0140-6736(07)61488-3
   DUNAIF A, 1989, DIABETES, V38, P1165, DOI 10.2337/diabetes.38.9.1165
   Everson-Rose SA, 2004, DIABETES CARE, V27, P2856, DOI 10.2337/diacare.27.12.2856
   FREEMAN H, 1946, ARCH NEURO PSYCHIATR, V56, P74, DOI 10.1001/archneurpsyc.1946.02300180084007
   Gans ROB, 2006, MED CLIN N AM, V90, P573, DOI 10.1016/j.mcna.2006.05.002
   Gold P.W., 2005, SOC BIOL PSYCH 60 AN
   Matsuda M, 1999, DIABETES CARE, V22, P1462, DOI 10.2337/diacare.22.9.1462
   McCowan PK, 1931, J MENT SCI, V77, P525, DOI 10.1192/bjp.77.318.525
   McIntyre RS, 2009, CURR DIABETES REP, V9, P51, DOI 10.1007/s11892-009-0010-0
   McLaughlin T, 2005, AM J CARDIOL, V96, P399, DOI 10.1016/j.amjcard.2005.03.085
   McLaughlin T, 2003, ANN INTERN MED, V139, P802, DOI 10.7326/0003-4819-139-10-200311180-00007
   MENNAPERPER M, 1984, PSYCHONEUROENDOCRINO, V9, P161, DOI 10.1016/0306-4530(84)90035-0
   MUELLER PS, 1969, ARCH GEN PSYCHIAT, V21, P587
   MUELLER PS, 1969, ARCH GEN PSYCHIAT, V21, P470
   NATHAN RS, 1981, PSYCHIAT RES, V4, P291, DOI 10.1016/0165-1781(81)90031-7
   Nissen SE, 2007, NEW ENGL J MED, V356, P2457, DOI 10.1056/NEJMoa072761
   Okamura F, 2000, METABOLISM, V49, P1255, DOI 10.1053/meta.2000.9515
   Pan A, 2008, J AFFECT DISORDERS, V109, P75, DOI 10.1016/j.jad.2007.11.002
   PRYCE IG, 1958, J MENT SCI, V104, P421, DOI 10.1192/bjp.104.435.421
   Rasgon N, 2004, J GERONTOL A-BIOL, V59, P178
   Rasgon N, 2001, AM J GERIAT PSYCHIAT, V9, P444, DOI 10.1176/appi.ajgp.9.4.444
   Rasgon N.L., 2002, 155 ANN M AM PSYCH A
   Rasgon NL, 2005, NEUROBIOL AGING, V26, pS103
   Rasgon NL, 2005, J AFFECT DISORDERS, V89, P217, DOI 10.1016/j.jad.2005.08.002
   Rasgon NL, 2005, BIPOLAR DISORD, V7, P246, DOI 10.1111/j.1399-5618.2005.00201.x
   Rasgon NL, 2003, J AFFECT DISORDERS, V74, P299, DOI 10.1016/S0165-0327(02)00117-9
   SACHAR EJ, 1971, ARCH GEN PSYCHIAT, V25, P263
   Stemmle PG, 2008, J PSYCHIATR RES, V43, P341, DOI 10.1016/j.jpsychires.2008.04.003
   Weber-Hamann B, 2006, J CLIN PSYCHIAT, V67, P1856, DOI 10.4088/JCP.v67n1204
   WINOKUR A, 1988, AM J PSYCHIAT, V145, P325
   Wolkowitz O M, 2001, World J Biol Psychiatry, V2, P115
   WRIGHT JH, 1978, BRIT J PSYCHIAT, V132, P386, DOI 10.1192/bjp.132.4.386
NR 36
TC 82
Z9 91
U1 0
U2 2
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1537-744X
J9 THESCIENTIFICWORLDJO
JI TheScientificWorldJOURNAL
PY 2010
VL 10
BP 321
EP 328
DI 10.1100/tsw.2010.32
PG 8
WC Environmental Sciences; Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Science & Technology - Other Topics
GA 560WL
UT WOS:000274935000007
PM 20191245
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Ostrov, I
   Gong, YJ
   Zuk, JB
   Wickramasinghe, PCK
   Tmenova, I
   Roopchand, DE
   Zhao, LP
   Raskin, I
AF Ostrov, Ievgeniia
   Gong, Yongjia
   Zuk, Joshua B.
   Wickramasinghe, Purni C. K.
   Tmenova, Irina
   Roopchand, Diana E.
   Zhao, Liping
   Raskin, Ilya
TI Elemental iron protects gut microbiota against oxygen-induced dysbiosis
SO PLOS ONE
LA English
DT Article
ID OXIDATIVE STRESS; AKKERMANSIA-MUCINIPHILA; METABOLIC SYNDROME;
   PATHOGENESIS; HEALTH; CROSSTALK; DISEASES; TISSUE; MODEL; DIET
AB Gut dysbiosis induced by oxygen and reactive oxygen species may be related to the development of inflammation, resulting in metabolic syndrome and associated-conditions in the gut. Here we show that elemental iron can serve as an antioxidant and reverse the oxygen-induced dysbiosis. Fecal samples from three healthy donors were fermented with elemental iron and/or oxygen. 16S rRNA analysis revealed that elemental iron reversed the oxygen-induced disruption of Shannon index diversity of the gut microbiota.The bacteria lacking enzymatic antioxidant systems also increased after iron treatment. Inter-individual differences, which corresponded to iron oxidation patterns, were observed for the tested donors. Gut bacteria responding to oxygen and iron treatments were identified as guilds, among which, Escherichia-Shigella was promoted by oxygen and depressed by elemental iron, while changes in bacteria such as Bifidobacterium, Blautia, Eubacterium, Ruminococcaceae, Flavonifractor, Oscillibacter, and Lachnospiraceae were reversed by elemental iron after oxygen treatment. Short-chain fatty acid production was inhibited by oxygen and this effect was partially reversed by elemental iron. These results suggested that elemental iron can regulate the oxygen/ROS state and protect the gut microbiota from oxidative stress.
C1 [Ostrov, Ievgeniia; Zuk, Joshua B.; Tmenova, Irina; Raskin, Ilya] Rutgers State Univ, Sch Environm & Biol Sci, Dept Plant Biol, New Brunswick, NJ 08854 USA.
   [Gong, Yongjia; Wickramasinghe, Purni C. K.; Roopchand, Diana E.] Rutgers State Univ, Sch Environm & Biol Sci, Dept Food Sci, New Brunswick, NJ USA.
   [Zhao, Liping] Rutgers State Univ, Sch Environm & Biol Sci, Dept Biochem & Microbiol, New Brunswick, NJ USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University System; Rutgers University New Brunswick; Rutgers University
   System; Rutgers University New Brunswick
RP Raskin, I (corresponding author), Rutgers State Univ, Sch Environm & Biol Sci, Dept Plant Biol, New Brunswick, NJ 08854 USA.
EM raskin@rutgers.edu
RI Zhao, Liping/AEA-4833-2022
OI Raskin, Ilya/0000-0002-3025-8112
FU U.S.-Israel Binational Agricultural Research and Development Fund (BARD)
   (Vaadia-BARD Postdoctoral Fellowship) [Fl-580-2018]; NIH / NCCIH
   Postdoctoral Training Grant [5T32AT004094]; NIH / ODS / NCCIH Botanical
   Center Grant [P50 AT002776]
FX <STRONG> </STRONG>This work was supported by the U.S.-Israel Binational
   Agricultural Research and Development Fund (BARD) (Vaadia-BARD
   Postdoctoral Fellowship Proposal No. Fl-580-2018 to I.O.), the NIH /
   NCCIH Postdoctoral Training Grant (5T32AT004094 to J.B.Z.), and by NIH /
   ODS / NCCIH Botanical Center Grant (P50 AT002776 to I.R.). The funders
   had no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
CR Abbaspour N, 2014, J RES MED SCI, V19, P164
   Agus A, 2016, SCI REP-UK, V6, DOI 10.1038/srep19032
   Apprill A, 2015, AQUAT MICROB ECOL, V75, P129, DOI 10.3354/ame01753
   Avelar Thalia M. T., 2015, J. Bras. Patol. Med. Lab., V51, P231
   Baldelli V, 2021, MICROORGANISMS, V9, DOI 10.3390/microorganisms9040697
   Barrett E, 2012, J APPL MICROBIOL, V113, P411, DOI 10.1111/j.1365-2672.2012.05344.x
   BLAND JM, 1995, BRIT MED J, V310, P446, DOI 10.1136/bmj.310.6977.446
   Bokulich NA, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0470-z
   Bolyen E, 2019, NAT BIOTECHNOL, V37, P852, DOI 10.1038/s41587-019-0209-9
   Byndloss MX, 2017, SCIENCE, V357, P570, DOI 10.1126/science.aam9949
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Camilleri M, 2019, GUT, V68, P1516, DOI 10.1136/gutjnl-2019-318427
   Carroll IM, 2012, NEUROGASTROENT MOTIL, V24, P521, DOI 10.1111/j.1365-2982.2012.01891.x
   Chang CJ, 2019, J FOOD DRUG ANAL, V27, P615, DOI 10.1016/j.jfda.2018.12.011
   Chen JJ, 2012, BRIT J NUTR, V107, P1429, DOI 10.1017/S0007114511004491
   Chen LP, 2014, MEDICINE, V93, DOI 10.1097/MD.0000000000000051
   Cianci R, 2022, CURR MED CHEM, V29, P3189, DOI 10.2174/0929867329666220105121124
   Costea PI, 2017, NAT BIOTECHNOL, V35, P1069, DOI 10.1038/nbt.3960
   CUMMINGS JH, 1979, AM J CLIN NUTR, V32, P2094, DOI 10.1093/ajcn/32.10.2094
   Curtis MM, 2014, CELL HOST MICROBE, V16, P759, DOI 10.1016/j.chom.2014.11.005
   den Hartigh LJ, 2018, J NUTR, V148, P562, DOI 10.1093/jn/nxy011
   Derrien M, 2004, INT J SYST EVOL MICR, V54, P1469, DOI 10.1099/ijs.0.02873-0
   Dubourg G, 2016, BMJ OPEN GASTROENTER, V3, DOI 10.1136/bmjgast-2016-000080
   Guss JD, 2019, OSTEOARTHR CARTILAGE, V27, P129, DOI 10.1016/j.joca.2018.07.020
   Hopps E, 2010, NUTR METAB CARDIOVAS, V20, P72, DOI 10.1016/j.numecd.2009.06.002
   Kelly CJ, 2015, CELL HOST MICROBE, V17, P662, DOI 10.1016/j.chom.2015.03.005
   Kundra P, 2021, MOL NUTR FOOD RES, V65, DOI 10.1002/mnfr.201901271
   Liu G, 2018, BIOMED RES INT, V2018, DOI 10.1155/2018/5606845
   Liu XM, 2021, GUT MICROBES, V13, DOI 10.1080/19490976.2021.1875796
   Long WM, 2015, SCI REP-UK, V5, DOI 10.1038/srep13469
   Mahjoub S, 2012, CASP J INTERN MED, V3, P386
   Maier E, 2015, NUTRIENTS, V7, P45, DOI 10.3390/nu7010045
   Mallick H, 2021, PLOS COMPUT BIOL, V17, DOI 10.1371/journal.pcbi.1009442
   Martin M., 2011, CUTADAPT REMOVES ADA, V17, P3, DOI DOI 10.14806/EJ.17.1.200
   Miquel S, 2015, MBIO, V6, DOI 10.1128/mBio.00300-15
   Miyauchi T, 2014, J NEUROTRAUM, V31, P773, DOI 10.1089/neu.2013.3181
   Moreno-Indias I, 2016, FOOD FUNCT, V7, P1775, DOI [10.1039/C5FO00886G, 10.1039/c5fo00886g]
   Nallu A, 2017, TRANSL RES, V179, P24, DOI 10.1016/j.trsl.2016.04.007
   Ng KM, 2013, NATURE, V502, P96, DOI 10.1038/nature12503
   Oliphant K, 2019, MICROBIOME, V7, DOI 10.1186/s40168-019-0704-8
   Palmieri VO, 2006, J NUTR, V136, P3022, DOI 10.1093/jn/136.12.3022
   Parada AE, 2016, ENVIRON MICROBIOL, V18, P1403, DOI 10.1111/1462-2920.13023
   Phipps O, 2020, NUTRIENTS, V12, DOI 10.3390/nu12092512
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   Rigottier-Gois L, 2013, ISME J, V7, P1256, DOI 10.1038/ismej.2013.80
   Rivera-Chávez F, 2017, FREE RADICAL BIO MED, V105, P93, DOI 10.1016/j.freeradbiomed.2016.09.022
   Roopchand DE, 2015, DIABETES, V64, P2847, DOI 10.2337/db14-1916
   Sekirov I, 2010, PHYSIOL REV, V90, P859, DOI 10.1152/physrev.00045.2009
   Shi YS, 2020, BIOINFORMATICS, V36, P4099, DOI 10.1093/bioinformatics/btaa276
   Shin J, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.01137
   Spahis S, 2017, ANTIOXID REDOX SIGN, V26, P445, DOI 10.1089/ars.2016.6756
   Tang WHW, 2017, CIRC RES, V120, P1183, DOI 10.1161/CIRCRESAHA.117.309715
   Thorkildsen LT, 2013, GASTROENT RES PRACT, V2013, DOI 10.1155/2013/636785
   Tomasello G, 2016, BIOMED PAP, V160, P461, DOI 10.5507/bp.2016.052
   Vacca M, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8040573
   Van Buiten CB, 2021, FREE RADICAL BIO MED, V168, P203, DOI 10.1016/j.freeradbiomed.2021.03.032
   Vona R, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8267234
   Wang J., 2018, PREPRINT
   Winn NC, 2020, JCI INSIGHT, V5, DOI 10.1172/jci.insight.132964
   Wrzosek L, 2013, BMC BIOL, V11, DOI 10.1186/1741-7007-11-61
   Wu GJ, 2021, GENOME MED, V13, DOI 10.1186/s13073-021-00840-y
   Wu ZQ, 2021, MICROBIOME, V9, DOI 10.1186/s40168-020-00965-z
   Yilmaz B, 2018, PHARMACEUTICALS-BASE, V11, DOI 10.3390/ph11040098
   Yu Z, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-25041-4
   Zhao LP, 2013, NAT REV MICROBIOL, V11, P639, DOI 10.1038/nrmicro3089
NR 65
TC 0
Z9 0
U1 2
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 27
PY 2024
VL 19
IS 2
AR e0298592
DI 10.1371/journal.pone.0298592
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA MV9G9
UT WOS:001196523000040
PM 38412144
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Beltrame, JF
   Crea, F
   Camici, P
AF Beltrame, John F.
   Crea, Filippo
   Camici, Paolo
TI Advances in Coronary Microvascular Dysfunction
SO HEART LUNG AND CIRCULATION
LA English
DT Article; Proceedings Paper
CT 56th Annual Scientific Meeting of the
   Cardiac-Society-of-Australia-and-New-Zealand
CY AUG 07-10, 2008
CL Adelaide, AUSTRALIA
SP Cardiac Soc Australia & New Zealand
DE Microcirculation; Syndrome X; Coronary flow reserve; Coronary heart
   disease
ID MYOCARDIAL BLOOD-FLOW; CONVERTING ENZYME-INHIBITION; EXERCISE-INDUCED
   ANGINA; ST-SEGMENT DEPRESSION; CARDIAC SYNDROME-X; CHEST-PAIN;
   ARTERY-DISEASE; VASODILATOR RESERVE; PECTORIS; ISCHEMIA
AB Considerable focus has been directed towards coronary arterial disease in the management of coronary heart disease, however the coronary microcirculation plays a major role in the regulation of coronary blood flow. Thus while we have multiple medical and revascularisation therapies to treat large vessel coronary artery disease, therapies directed towards the microcirculation are very limited.
   This review paper summarises important aspects of coronary microvascular dysfunction including (a) methods of assessment, (b) clinical classification of associated disorders, (c) possible pathophysiological mechanisms, and (d) potential therapies. Hence this will provide important background to advancing our understanding and management of coronary heart disease by targeting the coronary microcirculation.
C1 [Beltrame, John F.] Univ Adelaide, Cardiol Unit, Queen Elizabeth Hosp, Lyell McEwin Hlth Serv, Adelaide, SA, Australia.
   [Crea, Filippo] Univ Cattolica Sacro Cuore, Inst Cardiol, I-00168 Rome, Italy.
   [Camici, Paolo] Univ London Imperial Coll Sci Technol & Med, Ctr Clin Sci, London, England.
   [Camici, Paolo] Univ London Imperial Coll Sci Technol & Med, NHLI, London, England.
C3 University of Adelaide; Lyell McEwin Hospital; Catholic University of
   the Sacred Heart; IRCCS Policlinico Gemelli; Imperial College London;
   Imperial College London
RP Beltrame, JF (corresponding author), Queen Elizabeth Hosp, Cardiol Unit, 28 Woodville Rd, Woodville, SA 5011, Australia.
EM john.beltrame@adelaide.edu.au
RI Camici, Paolo/AAN-1959-2020; Crea, Filippo/AAC-9754-2022; Beltrame,
   John/C-1687-2017
FU MRC [MC_U120084164] Funding Source: UKRI
CR Abbate A, 2008, EUR HEART J, V29, P1795, DOI 10.1093/eurheartj/ehn281
   Al Suwaidi J, 1999, ANN INTERN MED, V131, P838, DOI 10.7326/0003-4819-131-11-199912070-00007
   ARBOGAST R, 1973, AM J CARDIOL, V32, P257, DOI 10.1016/S0002-9149(73)80130-4
   *AUSTR I HLTH WELF, 2004, CVD27 AIHW NAT HEART
   Beltrame JF, 2005, EUR HEART J, V26, P946, DOI 10.1093/eurheartj/ehi242
   Beltrame JF, 2004, J AM COLL CARDIOL, V44, P57, DOI 10.1016/j.jacc.2004.03.055
   Beltrame JF, 2003, AM HEART J, V146, P84, DOI 10.1016/S0002-8703(03)00124-8
   Beltrame JF, 2002, CARDIOLOGY, V97, P197, DOI 10.1159/000063121
   BELTRAME JF, 2006, BRAUNWALDS HEART DIS
   BELTRAME JF, 2008, HEART LUNG CIRC S3, V17, pS100
   Botker HE, 1998, AM J CARDIOL, V82, P1352, DOI 10.1016/S0002-9149(98)00640-7
   BOTKER HE, 1993, LANCET, V342, P136
   Bottcher M, 1999, CIRCULATION, V99, P1795
   Camici PG, 2007, EUR HEART J, V28, P1539, DOI 10.1093/eurheartj/ehm167
   Camici PG, 2007, NEW ENGL J MED, V356, P830, DOI 10.1056/NEJMra061889
   CAMICI PG, 1992, CIRCULATION, V86, P179, DOI 10.1161/01.CIR.86.1.179
   CAMICI PG, 1991, J AM COLL CARDIOL, V17, P1461, DOI 10.1016/0735-1097(91)90632-J
   CANNON RO, 1983, J AM COLL CARDIOL, V1, P1359, DOI 10.1016/S0735-1097(83)80037-0
   CANNON RO, 1994, NEW ENGL J MED, V330, P1411, DOI 10.1056/NEJM199405193302003
   Cecchi F, 2003, NEW ENGL J MED, V349, P1027, DOI 10.1056/NEJMoa025050
   Chauhan A, 1997, EUR HEART J, V18, P60
   Chen JW, 2002, AM J CARDIOL, V90, P974, DOI 10.1016/S0002-9149(02)02664-4
   Chen JW, 1997, AM J CARDIOL, V80, P32
   Cunningham C, 2000, AM J CARDIOL, V85, P653, DOI 10.1016/S0002-9149(99)00828-0
   DAYANIKLI F, 1994, CIRCULATION, V90, P808, DOI 10.1161/01.CIR.90.2.808
   Di Carli MF, 2003, J AM COLL CARDIOL, V41, P1387, DOI 10.1016/S0735-1097(03)00166-9
   EGASHIRA K, 1993, NEW ENGL J MED, V328, P1659, DOI 10.1056/NEJM199306103282302
   Elliott PM, 2006, HEART, V92, P357, DOI 10.1136/hrt.2004.054015
   Elliott PM, 1997, HEART, V77, P523, DOI 10.1136/hrt.77.6.523
   EPSTEIN SE, 1991, CIRCULATION, V83, P73
   GALASSI AR, 1993, AM J CARDIOL, V72, P134, DOI 10.1016/0002-9149(93)90148-6
   GALASSI AR, 1989, AM J CARDIOL, V64, P264, DOI 10.1016/0002-9149(89)90517-1
   GHAFFARI N, 2008, HEART LUNG CIRC S, V17, pS236
   GOULD KL, 1974, AM J CARDIOL, V33, P87, DOI 10.1016/0002-9149(74)90743-7
   Gregorini L, 1999, CIRCULATION, V99, P482, DOI 10.1161/01.CIR.99.4.482
   Gregorini L, 1998, J AM COLL CARDIOL, V31, P992, DOI 10.1016/S0735-1097(98)00055-2
   INOUE T, 1993, AM HEART J, V125, P93, DOI 10.1016/0002-8703(93)90061-D
   Julius BK, 1997, CIRCULATION, V95, P892
   Kaski JC, 1999, DEV CARDIOVASC MED, V213, P1
   KASKI JC, 1994, J AM COLL CARDIOL, V23, P652, DOI 10.1016/0735-1097(94)90750-1
   Kaufmann PA, 2000, J AM COLL CARDIOL, V36, P103, DOI 10.1016/S0735-1097(00)00697-5
   Kaufmann PA, 2000, CIRCULATION, V102, P1233, DOI 10.1161/01.CIR.102.11.1233
   Kaufmann PA, 2005, J NUCL MED, V46, P75
   Kayikcioglu M, 2003, EUR HEART J, V24, P1999, DOI 10.1016/S0195-668X(03)00478-0
   KEMP HG, 1973, AM J MED, V54, P735, DOI 10.1016/0002-9343(73)90060-0
   Kume T, 2005, CIRC J, V69, P934, DOI 10.1253/circj.69.934
   Kurtoglu N, 2001, AM J CARDIOL, V87, P777, DOI 10.1016/S0002-9149(00)01503-4
   LAGERQVIST B, 1992, BRIT HEART J, V68, P282
   Laine H, 1998, J AM COLL CARDIOL, V32, P147, DOI 10.1016/S0735-1097(98)00222-8
   Lanza G A, 1997, G Ital Cardiol, V27, P50
   Lanza GA, 1999, AM J CARDIOL, V84, P854, DOI 10.1016/S0002-9149(99)00450-6
   LANZA GA, 2005, EUR HEART J, V9, P9
   LESLIE S, 2005, HEART LUNG CIRC, V14, pS81
   LIKOFF W, 1967, NEW ENGL J MED, V276, P1063, DOI 10.1056/NEJM196705112761904
   LUCARINI AR, 1992, CLIN EXP HYPERTENS A, V14, P55, DOI 10.3109/10641969209036171
   Mangieri E, 1996, CATHETER CARDIO DIAG, V37, P375, DOI 10.1002/(SICI)1097-0304(199604)37:4<375::AID-CCD7>3.0.CO;2-8
   Marzilli M, 2002, J AM COLL CARDIOL, V40, P2102, DOI 10.1016/S0735-1097(02)02590-1
   MASERI A, 1991, J AM COLL CARDIOL, V17, P499, DOI 10.1016/S0735-1097(10)80122-6
   MASERI A, 1995, ISCHEMIC HEART DIS R, P507
   MASERI A, 1995, ISCHEMIC HEART DIS R, V4, P71
   Mohri M, 2003, J AM COLL CARDIOL, V41, P15, DOI 10.1016/S0735-1097(02)02632-3
   MOSSERI M, 1986, CIRCULATION, V74, P964, DOI 10.1161/01.CIR.74.5.964
   Muller JM, 1996, CARDIOVASC RES, V32, P668, DOI 10.1016/0008-6363(96)00111-3
   Nalbantgil, 1999, Int J Angiol, V8, P40, DOI 10.1007/BF01616842
   NEMES A, 2002, J AM COLL CARDIOL  S, V9, pB256
   Panting JR, 2002, NEW ENGL J MED, V346, P1948, DOI 10.1056/NEJMoa012369
   PUPITA G, 1990, NEW ENGL J MED, V323, P514, DOI 10.1056/NEJM199008233230804
   Rosano GMC, 1996, J AM COLL CARDIOL, V28, P1500
   Rosen SD, 2002, HEART, V87, P513, DOI 10.1136/heart.87.6.513
   ROSEN SD, 1994, CIRCULATION, V90, P50, DOI 10.1161/01.CIR.90.1.50
   SAMBUCETI G, 1993, AM J CARDIOL, V72, P538, DOI 10.1016/0002-9149(93)90348-G
   Shimokawa H, 2008, J CARDIOL, V52, P67, DOI 10.1016/j.jjcc.2008.07.016
   Spyrou N, 2000, AM J PHYSIOL-HEART C, V279, pH2634, DOI 10.1152/ajpheart.2000.279.6.H2634
   Sun HT, 2002, J AM COLL CARDIOL, V39, P847, DOI 10.1016/S0735-1097(02)01690-X
   TAMBE AA, 1972, AM HEART J, V84, P66, DOI 10.1016/0002-8703(72)90307-9
   Toyota E, 2001, J NUCL CARDIOL, V8, P599, DOI 10.1067/mnc.2001.118068
   UREN NG, 1993, J AM COLL CARDIOL, V21, P612, DOI 10.1016/0735-1097(93)90092-F
   UREN NG, 1994, NEW ENGL J MED, V331, P222, DOI 10.1056/NEJM199407283310402
   Yang EH, 2004, AM J CARDIOL, V94, P685, DOI 10.1016/j.amjcard.2004.05.046
   Yokoyama I, 1997, J AM COLL CARDIOL, V30, P1472, DOI 10.1016/S0735-1097(97)00327-6
NR 80
TC 50
Z9 54
U1 1
U2 16
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1443-9506
EI 1444-2892
J9 HEART LUNG CIRC
JI Heart Lung Circ.
PD FEB
PY 2009
VL 18
IS 1
BP 19
EP 27
DI 10.1016/j.hlc.2008.11.002
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology
GA 414LY
UT WOS:000263866500005
PM 19119077
DA 2025-06-11
ER

PT J
AU Folchetti, LD
   Monfort-Pires, M
   de Barros, CR
   Martini, LA
   Ferreira, SRG
AF Folchetti, Luciana Dias
   Monfort-Pires, Milena
   de Barros, Camila R.
   Martini, Ligia Araujo
   Gouvea Ferreira, Sandra Roberta
TI Association of fruits and vegetables consumption and related-vitamins
   with inflammatory and oxidative stress markers in prediabetic
   individuals
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Fruits and vegetables; Vitamins; Oxidative stress; Insulin resistance;
   Inflammation
ID NUTRITION EXAMINATION SURVEY; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; DIETARY-INTAKE; NATURAL ANTIOXIDANTS;
   NATIONAL-HEALTH; YOUNG-ADULTS; US ADULTS; RISK; METAANALYSIS
AB Background: Dietary guidelines of 5 servings per day of fruits and vegetables (FV) offer a reasonable amount of vitamins to control organic processes, which may contribute to a favorable cardiometabolic profile. This study aimed at investigating whether the intake of the FV group as well as pro-vitamin A carotenoids and vitamins C and E were associated with circulating markers of oxidative stress, inflammation and insulin resistance in Brazilians individuals at cardiometabolic risk.
   Methods: This cross-sectional study included 205 individuals screened for diabetes prevention program in a healthcare center from the School of Public Health, University of Sao Paulo, conducted in 2008. Possible associations of consumption of FV group, as well as pro-vitamin A carotenoids and vitamins C and E, with circulating markers of oxidative stress (superoxide dismutase - SOD and oxidized LDL - oxLDL), inflammation (C reactive protein, TNF-alpha and adiponectin) and insulin resistance (HOMA-IR) were investigated. Pearson correlation coefficient, ANOVA and multiple linear regression were employed.
   Results: The sample (64.7% women) had a mean age of 54.1 +/- 12.7 years and body mass index of 30.7 +/- 5.7 kg/m2. Dietary, physical activity, anthropometric and laboratory data were obtained. Participants consumed a mean of 3.8 servings/day of FV; their FV intake was categorized into three groups: < 2.5, 2.5-5.0 and >5.0 servings/day. Significant trends for lower waist circumference (103.4 +/- 13.6 vs. 100.1 +/- 12.2 vs. 98.2 +/- 12.7 cm, p-trend < 0.05) and higher adiponectin concentrations (10.4 +/- 1.8 vs. 11.9 +/- 1.9 vs. 13.6 +/- 2.1 ng/mL, p-trend <0.05) were detected across categories. Associations between SOD concentrations (beta 0.172 [ 0.110-0.688]) with FV consumption and between oxLDL concentrations with vitamins C (beta -0.333 [-2.568 - -0.218]) and E (beta -0.354 [-1.131- -0.110]) intakes, adjusted for age, gender, BMI, saturated fat intake, smoking and physical activity were found. Similar results were observed for the associations between oxLDL and FV intake, but significance disappeared adding adjustment for saturated fat, smoking and physical activity.
   Conclusion: Our data suggest that the intake of FV or selected vitamins may be useful for identifying the oxidative stress and inflammation involved in the genesis of cardiometabolic diseases and for motivating at-risk patients for changing dietary habits.
C1 [Folchetti, Luciana Dias; Monfort-Pires, Milena; de Barros, Camila R.; Martini, Ligia Araujo; Gouvea Ferreira, Sandra Roberta] Univ Sao Paulo, Fac Saude Publ, Dept Nutr, BR-01246904 Sao Paulo, Brazil.
C3 Universidade de Sao Paulo
RP Ferreira, SRG (corresponding author), Univ Sao Paulo, Fac Saude Publ, Dept Nutr, Av Dr Arnaldo 715, BR-01246904 Sao Paulo, Brazil.
EM sandrafv@usp.br
RI Martini, Ligia/C-7279-2012; Folchetti, Luciana/B-2597-2016; Ferreira,
   Sandra/B-9840-2012; Stefanadis, Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454; Monfort-Pires,
   Milena/0000-0002-1652-8083; Ferreira, Sandra/0000-0002-7015-7391; Araujo
   Martini, Ligia/0000-0001-8409-2907
FU Sao Paulo Foundation for Research Support - FAPESP; Coordination for
   Improvement of Graduate Personnel - CAPES (Brazil)
FX This work was supported by a grant from The Sao Paulo Foundation for
   Research Support - FAPESP and from Coordination for Improvement of
   Graduate Personnel - CAPES (Brazil).
CR ADA - American Diabetes Association, 2012, DIABETES CARE S1, V35, pS62
   [Anonymous], 2002, Diet, Nutrition and the Prevention of Chronic Diseases
   [Anonymous], 2005, Tabela para avaliacao de consumo alimentar em medidas caseiras
   [Anonymous], 2007, DEV EVALUATION HLTH
   Bazzano LA, 2002, AM J CLIN NUTR, V76, P93
   Beydoun MA, 2011, J NUTR, V141, P903, DOI 10.3945/jn.110.136580
   Boeing H, 2012, EUR J NUTR, V51, P637, DOI 10.1007/s00394-012-0380-y
   Bruun JM, 2003, AM J PHYSIOL-ENDOC M, V285, pE527, DOI 10.1152/ajpendo.00110.2003
   Carter P, 2010, BMJ-BRIT MED J, V341, DOI 10.1136/bmj.c4229
   Cooper AJ, 2012, EUR J CLIN NUTR, V66, P1082, DOI 10.1038/ejcn.2012.85
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   Detopoulou P, 2010, EUR J CLIN NUTR, V64, P161, DOI 10.1038/ejcn.2009.130
   Dragsted LO, 2004, AM J CLIN NUTR, V79, P1060
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Galic S, 2010, MOL CELL ENDOCRINOL, V316, P129, DOI 10.1016/j.mce.2009.08.018
   Geloneze B, 2006, DIABETES RES CLIN PR, V72, P219, DOI 10.1016/j.diabres.2005.10.017
   Helmersson J, 2009, BRIT J NUTR, V101, P1775, DOI 10.1017/S0007114508147377
   Henriksen EJ, 2011, FREE RADICAL BIO MED, V51, P993, DOI 10.1016/j.freeradbiomed.2010.12.005
   Hermsdorff HHM, 2012, BRIT J NUTR, V107, P1119, DOI 10.1017/S0007114511004235
   Hermsdorff HHM, 2010, NUTR METAB, V7, DOI 10.1186/1743-7075-7-42
   Institute of Medicine, 2000, DRI REP DIET REF INT
   Institute of Medicine, 2001, DRI REP DIET REF INT
   Jacobs DR, 2003, AM J CLIN NUTR, V78, p508S, DOI 10.1093/ajcn/78.3.508S
   Joshipura KJ, 2001, ANN INTERN MED, V134, P1106, DOI 10.7326/0003-4819-134-12-200106190-00010
   Kaaks R, 2006, ANN EPIDEMIOL, V16, P377, DOI 10.1016/j.annepidem.2005.06.057
   Kizhakekuttu TJ, 2010, CARDIOVASC THER, V28, pe20, DOI 10.1111/j.1755-5922.2010.00137.x
   Landete JM, 2013, CRIT REV FOOD SCI, V53, P706, DOI 10.1080/10408398.2011.555018
   Liu RH, 2013, ADV NUTR, V4, p384S, DOI 10.3945/an.112.003517
   Liu S, 2000, AM J CLIN NUTR, V72, P922
   Núñez-Córdoba JM, 2011, CURR TOP MED CHEM, V11, P1861
   Pomerleau J, 2004, J NUTR, V134, P1175, DOI 10.1093/jn/134.5.1175
   Rains JL, 2011, FREE RADICAL BIO MED, V50, P567, DOI 10.1016/j.freeradbiomed.2010.12.006
   Reifen R, 2002, P NUTR SOC, V61, P397, DOI 10.1079/PNS2002172
   Reuter S, 2010, FREE RADICAL BIO MED, V49, P1603, DOI 10.1016/j.freeradbiomed.2010.09.006
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Saltiel AR, 2001, NATURE, V414, P799, DOI 10.1038/414799a
   Sartorellii DS, 2005, DIABETES CARE, V28, P2240, DOI 10.2337/diacare.28.9.2240
   Sluijs I, 2009, J NUTR, V139, P987, DOI 10.3945/jn.108.101451
   Soory Mena, 2009, Infectious Disorders - Drug Targets, V9, P400
   Tomey KM, 2007, J NUTR, V137, P2412, DOI 10.1093/jn/137.11.2412
   Traber MG, 2011, FREE RADICAL BIO MED, V51, P1000, DOI 10.1016/j.freeradbiomed.2011.05.017
   Van Guilder GP, 2006, OBESITY, V14, P2127, DOI 10.1038/oby.2006.248
   World Health Organization, 2004, JOINT WHO FAO EXP CO
   Yeon JY, 2012, PREV MED, V54, pS109, DOI 10.1016/j.ypmed.2011.12.026
NR 44
TC 22
Z9 25
U1 0
U2 20
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD FEB 18
PY 2014
VL 6
AR 22
DI 10.1186/1758-5996-6-22
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AB9HW
UT WOS:000332103600001
PM 24548603
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kalra, S
   Kumar, KVSH
AF Kalra, Sanjay
   Kumar, K. V. S. Hari
TI Seven Sinful Sisters: Seven Smart Solutions to Stop Diabetes
SO JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION
LA English
DT Article
DE Diabetes; hypertension; metabolic syndrome; obesity; prevention; public
   health; salutogenesis
AB This article describes a Seven Sinful Sisters and Smart Solutions (FIVE S) concept, which lists seven contributory factors of diabetes, and seven potential solutions to help prevent its spread. The Seven Sinful Sisters include Sugar, Salt, Saturated fat, Spirits (alcohol), Sitting time (sedentary life style), Steroids (including other drugs) and Stress. Seven Smart salutogenic Solutions are use of Self-restraint, Small size portions, Spices (nutrition -based remedies, including sugar and salt substitutes), Slimnastics (a synonym for aerobic exercise), high Spirit (a positive attitude), health Sleep/Siesta, and enjoyment of Sunday (or Stress management).
C1 [Kalra, Sanjay] Bharti Hosp, Dept Endocrinol, Karnal, India.
   [Kumar, K. V. S. Hari] R&R Hosp, Dept Endocrinol, New Delhi, India.
RP Kalra, S (corresponding author), Bharti Hosp, Dept Endocrinol, Karnal, India.
EM brideknl@gmail.com
CR Page-Reeves J, 2013, QUAL REP, V18
   Sharma R, 2017, J SOC HLTH DIABETES, V5, P12
   Tunceli K, 2005, DIABETES CARE, V28, P2662, DOI 10.2337/diacare.28.11.2662
NR 3
TC 1
Z9 1
U1 0
U2 3
PU PAKISTAN MEDICAL ASSOC
PI KARACHI
PA PMA HOUSE, AGA KHAN III RD, KARACHI, 00000, PAKISTAN
SN 0030-9982
J9 J PAK MED ASSOC
JI J. Pak. Med. Assoc.
PD NOV
PY 2018
VL 68
IS 11
BP 1727
EP 1728
PG 2
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA HC8BN
UT WOS:000452026500036
PM 30410162
DA 2025-06-11
ER

PT J
AU Petta, S
   Muratore, C
   Craxì, A
AF Petta, S.
   Muratore, C.
   Craxi, A.
TI Non-alcoholic fatty liver disease pathogenesis: The present and the
   future
SO DIGESTIVE AND LIVER DISEASE
LA English
DT Review
DE Insulin resistance; Non-alcoholic fatty liver disease; Non-alcoholic
   steatohepatitis; Steatosis
ID ACTIVATED-RECEPTOR-ALPHA; CHRONIC HEPATITIS-C; TRIGLYCERIDE TRANSFER
   PROTEIN; ENDOPLASMIC-RETICULUM STRESS; NECROSIS-FACTOR-ALPHA;
   NF-KAPPA-B; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE-STRESS;
   ANGIOTENSIN-II
AB Non-alcoholic fatty liver disease is the clinical hepatic expression of metabolic syndrome. The prevalence of non-alcoholic fatty liver disease is around 20-30%, and with a rapid increase in the metabolic risk factors in the general population, non-alcoholic fatty liver disease has become the most common cause of liver disease worldwide. A fraction (20-30%) of non-alcoholic fatty liver disease patients develop a potentially progressive hepatic disorder, namely non-alcoholic steatohepatitis, leading to end-stage liver disease. The pathogenesis of non-alcoholic fatty liver disease is not entirely understood, and even if insulin resistance is a major pathogenetic key, many other factors are implicated in both liver fat accumulation and disease progression to non-alcoholic steatohepatitis. In this review we aim to examine the literature, principally concerning human non-alcoholic fatty liver disease pathogenesis, and to identify the newest, most promising clinical and basic research data. (C) 2009 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
C1 [Petta, S.; Craxi, A.] Univ Palermo, Di Bi MIS, Cattedra & Unita Operat Gastroenterol, Palermo, Italy.
   [Muratore, C.] Univ Palermo, Dipartimento Materno Infantile, Div Neuropsichiatria Infantile, Palermo, Italy.
C3 University of Palermo; University of Palermo
RP Petta, S (corresponding author), Piazza Clin 2, I-90127 Palermo, Italy.
EM petsa@inwind.it
RI ; Craxi, Antonio/K-9529-2016
OI Petta, Salvatore/0000-0002-0822-9673; Craxi, Antonio/0000-0002-4480-9544
CR ADACHI Y, 1995, GASTROENTEROLOGY, V108, P218, DOI 10.1016/0016-5085(95)90027-6
   Adams LA, 2005, GASTROENTEROLOGY, V129, P113, DOI 10.1053/j.gastro.2005.04.014
   Adams LA, 2004, AM J GASTROENTEROL, V99, P2365, DOI 10.1111/j.1572-0241.2004.40064.x
   Adams LA, 2004, HEPATOLOGY, V39, P909, DOI 10.1002/hep.20140
   Angulo P, 2004, J HEPATOL, V41, P943, DOI 10.1016/j.jhep.2004.08.020
   [Anonymous], AM J MED S1
   Aoyama T, 1998, J BIOL CHEM, V273, P5678, DOI 10.1074/jbc.273.10.5678
   Arsov T, 2006, BIOCHEM BIOPH RES CO, V342, P1152, DOI 10.1016/j.bbrc.2006.02.032
   Ashton JC, 2004, J CARDIOVASC PHARM, V44, P517, DOI 10.1097/00005344-200411000-00001
   Balasubramanian S, 1998, HEPATOLOGY, V27, P62, DOI 10.1002/hep.510270111
   Battaglino R, 2004, J BONE MINER RES, V19, P1420, DOI 10.1359/JBMR.040606
   Bednarek-Tupikowska G, 2000, Med Sci Monit, V6, P40
   Bedogni G, 2005, HEPATOLOGY, V42, P44, DOI 10.1002/hep.20734
   Belfort R, 2006, NEW ENGL J MED, V355, P2297, DOI 10.1056/NEJMoa060326
   Beltowski Jerzy, 2003, Med Sci Monit, V9, pRA55
   Beraza N, 2008, GUT, V57, P655, DOI 10.1136/gut.2007.134288
   Bergamini CM, 2004, CURR PHARM DESIGN, V10, P1611, DOI 10.2174/1381612043384664
   Bergheim I, 2008, J HEPATOL, V48, P983, DOI 10.1016/j.jhep.2008.01.035
   Bifulco M, 2001, FASEB J, V15, P2745, DOI 10.1096/fj.01-0320fje
   Blindenbacher A, 2003, HEPATOLOGY, V38, P674, DOI 10.1053/jhep.2003.50378
   BOUCHER BJ, 1995, DIABETOLOGIA, V38, P1239, DOI 10.1007/BF00422375
   Browning JD, 2004, HEPATOLOGY, V40, P1387, DOI 10.1002/hep.20466
   Browning JD, 2004, J CLIN INVEST, V114, P147, DOI 10.1172/JCI200422422
   Bugianesi E, 2005, HEPATOLOGY, V42, P987, DOI 10.1002/hep.20920
   Bugianesi E, 2005, AM J GASTROENTEROL, V100, P1082, DOI 10.1111/j.1572-0241.2005.41583.x
   Bugianesi E, 2005, J CLIN ENDOCR METAB, V90, P3498, DOI 10.1210/jc.2004-2240
   Bugianesi E, 2006, HEPATOLOGY, V44, P1648, DOI 10.1002/hep.21429
   BULBRING E, 1958, BRIT J PHARM CHEMOTH, V13, P444
   Cai DS, 2005, NAT MED, V11, P183, DOI 10.1038/nm1166
   Carmiel-Haggai M, 2004, FASEB J, V18, P136, DOI 10.1096/fj.04-2291fje
   Chalasani N, 2004, AM J GASTROENTEROL, V99, P1497, DOI 10.1111/j.1572-0241.2004.30159.x
   Chalasani N, 2003, AM J GASTROENTEROL, V98, P2771, DOI [10.1016/j.amjgastroenterol.2003.09.037, 10.1111/j.1572-0241.2003.08767.x]
   Chao L, 2000, J CLIN INVEST, V106, P1221, DOI 10.1172/JCI11245
   Charlton M, 2008, HEPATOLOGY, V47, P484, DOI 10.1002/hep.22063
   Cheung O, 2007, HEPATOLOGY, V46, P1091, DOI 10.1002/hep.21803
   Chitturi S, 2002, HEPATOLOGY, V35, P373, DOI 10.1053/jhep.2002.30692
   Chitturi S, 2002, HEPATOLOGY, V36, P403, DOI 10.1053/jhep.2002.34738
   Chiu KC, 2004, AM J CLIN NUTR, V79, P820
   Choudhury Jayanta, 2004, Clin Liver Dis, V8, P575, DOI 10.1016/j.cld.2004.04.006
   Clément S, 2008, HEPATOLOGY, V48, P799, DOI 10.1002/hep.22404
   Crespo J, 2001, HEPATOLOGY, V34, P1158, DOI 10.1053/jhep.2001.29628
   Cressman DE, 1996, SCIENCE, V274, P1379, DOI 10.1126/science.274.5291.1379
   Czaja MJ, 2007, SEMIN LIVER DIS, V27, P378, DOI 10.1055/s-2007-991514
   Day CP, 2006, GASTROENTEROLOGY, V130, P207, DOI 10.1053/j.gastro.2005.11.017
   de Alwis NMW, 2007, SEMIN LIVER DIS, V27, P44, DOI 10.1055/s-2006-960170
   DECKER K, 1990, EUR J BIOCHEM, V192, P245, DOI 10.1111/j.1432-1033.1990.tb19222.x
   Denechaud PD, 2008, FEBS LETT, V582, P68, DOI 10.1016/j.febslet.2007.07.084
   Deng QG, 2005, HEPATOLOGY, V42, P905, DOI 10.1002/hep.20877
   Dentin R, 2006, DIABETES, V55, P2159, DOI 10.2337/db06-0200
   Desvergne B, 2007, VITAM HORM, V75, P1, DOI 10.1016/S0083-6729(06)75001-4
   Deutsch DG, 1997, J CLIN INVEST, V100, P1538, DOI 10.1172/JCI119677
   Dhatariya K, 2005, DIABETES, V54, P765, DOI 10.2337/diabetes.54.3.765
   Di Marzo V, 2004, NAT REV DRUG DISCOV, V3, P771, DOI 10.1038/nrd1495
   Ding XK, 2005, AM J PATHOL, V166, P1655, DOI 10.1016/S0002-9440(10)62476-5
   Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI23621
   DRENICK EJ, 1982, GASTROENTEROLOGY, V82, P535
   Edvardsson U, 1999, J LIPID RES, V40, P1177
   Ekstedt M, 2006, HEPATOLOGY, V44, P865, DOI 10.1002/hep.21327
   El-Assal O, 2004, CELL MOL IMMUNOL, V1, P205
   ESTERBAUER H, 1991, FREE RADICAL BIO MED, V11, P81, DOI 10.1016/0891-5849(91)90192-6
   Fabbrini E, 2008, GASTROENTEROLOGY, V134, P424, DOI 10.1053/j.gastro.2007.11.038
   Fassio E, 2004, HEPATOLOGY, V40, P820, DOI 10.1002/hep.20410
   Feldstein AE, 2005, FRONT BIOSCI-LANDMRK, V10, P3093, DOI 10.2741/1765
   Feldstein AE, 2004, HEPATOLOGY, V40, P185, DOI 10.1002/hep.20283
   Feldstein AE, 2003, GASTROENTEROLOGY, V125, P437, DOI 10.1016/S0016-5085(03)00907-7
   Feldstein AE, 2003, J HEPATOL, V39, P978, DOI 10.1016/S0168-8278(03)00460-4
   Ford ES, 2005, DIABETES CARE, V28, P1228, DOI 10.2337/diacare.28.5.1228
   Gambino R, 2007, HEPATOLOGY, V45, P1097, DOI 10.1002/hep.21631
   Gao ZG, 2004, MOL ENDOCRINOL, V18, P2024, DOI 10.1210/me.2003-0383
   Gary-Bobo M, 2007, HEPATOLOGY, V46, P122, DOI 10.1002/hep.21641
   Gavrilova O, 2003, J BIOL CHEM, V278, P34268, DOI 10.1074/jbc.M300043200
   Graham TE, 2006, NEW ENGL J MED, V354, P2552, DOI 10.1056/NEJMoa054862
   Haukeland JW, 2006, J HEPATOL, V44, P1167, DOI 10.1016/j.jhep.2006.02.011
   Hensley K, 2000, CARCINOGENESIS, V21, P983, DOI 10.1093/carcin/21.5.983
   Hertz R, 1998, TOXICOL LETT, V103, P85, DOI 10.1016/S0378-4274(98)00290-2
   Hézode C, 2005, HEPATOLOGY, V42, P63, DOI 10.1002/hep.20733
   Hezode C, 2008, GASTROENTEROLOGY, V134, P432, DOI 10.1053/j.gastro.2007.11.039
   Hirose A, 2007, HEPATOLOGY, V45, P1375, DOI 10.1002/hep.21638
   Hocking MP, 1998, DIGEST DIS SCI, V43, P2493, DOI 10.1023/A:1026698602714
   Holden PR, 1999, J MOL ENDOCRINOL, V22, P1, DOI 10.1677/jme.0.0220001
   Howard JK, 2006, TRENDS ENDOCRIN MET, V17, P365, DOI 10.1016/j.tem.2006.09.007
   Huang XD, 2008, WORLD J GASTROENTERO, V14, P2888, DOI 10.3748/wjg.14.2888
   Hui JM, 2004, HEPATOLOGY, V40, P46, DOI 10.1002/hep.20280
   Ikejima K, 2001, HEPATOLOGY, V34, P288, DOI 10.1053/jhep.2001.26518
   Ip E, 2003, HEPATOLOGY, V38, P123, DOI 10.1053/jhep.2003.50307
   Janke J, 2006, DIABETES, V55, P2805, DOI 10.2337/db06-0616
   Javor ED, 2005, HEPATOLOGY, V41, P753, DOI 10.1002/hep.20672
   Jin XL, 2006, HEPATOLOGY, V43, P474, DOI 10.1002/hep.21087
   Julien B, 2005, GASTROENTEROLOGY, V128, P742, DOI 10.1053/j.gastro.2004.12.050
   Kakuma T, 2000, P NATL ACAD SCI USA, V97, P8536, DOI 10.1073/pnas.97.15.8536
   KANAYAMA T, 2002, J BIOL CHEM, V277, P19353
   Kaser S, 2005, GUT, V54, P117, DOI 10.1136/gut.2003.037010
   Kashireddy PV, 2004, HEPATOL RES, V30, P104, DOI 10.1016/j.hepres.2004.06.004
   Kechagias S, 2008, GUT, V57, P649, DOI 10.1136/gut.2007.131797
   Kloeting N, 2007, CELL METAB, V6, P79, DOI 10.1016/j.cmet.2007.06.002
   Klover PJ, 2005, ENDOCRINOLOGY, V146, P3417, DOI 10.1210/en.2004-1468
   Kugelmas M, 2003, HEPATOLOGY, V38, P413, DOI 10.1053/jhep.2003.50316
   Kumar RN, 2001, ANAESTHESIA, V56, P1059, DOI 10.1046/j.1365-2044.2001.02269.x
   Lam TKT, 2002, AM J PHYSIOL-ENDOC M, V283, pE682, DOI 10.1152/ajpendo.00038.2002
   Larter CZ, 2006, J HEPATOL, V44, P253, DOI 10.1016/j.jhep.2005.11.030
   Lee JY, 2006, MOL CELLS, V21, P174
   Lesurtel M, 2006, SCIENCE, V312, P104, DOI 10.1126/science.1123842
   Li ZP, 2003, HEPATOLOGY, V37, P343, DOI 10.1053/jhep.2003.50048
   Lieber CS, 2004, AM J CLIN NUTR, V79, P502
   Lin HY, 2008, HEPATOLOGY, V47, P1924, DOI 10.1002/hep.22252
   Loguercio C, 2005, J CLIN GASTROENTEROL, V39, P540, DOI 10.1097/01.mcg.0000165671.25272.0f
   Lord GM, 1998, NATURE, V394, P897, DOI 10.1038/29795
   Louet JF, 2001, BIOCHEM J, V354, P189, DOI 10.1042/0264-6021:3540189
   Malhi H, 2006, J BIOL CHEM, V281, P12093, DOI 10.1074/jbc.M510660200
   Mantzoros CS, 1999, ANN INTERN MED, V130, P671, DOI 10.7326/0003-4819-130-8-199904200-00014
   Marchesini G, 2003, HEPATOLOGY, V37, P917, DOI 10.1053/jhep.2003.50161
   Marchesini G, 1999, AM J MED, V107, P450, DOI 10.1016/S0002-9343(99)00271-5
   Marchesini G, 2001, DIABETES, V50, P1844, DOI 10.2337/diabetes.50.8.1844
   Martín-Romero C, 2000, CELL IMMUNOL, V199, P15, DOI 10.1006/cimm.1999.1594
   Masaki T, 2004, HEPATOLOGY, V40, P177, DOI 10.1002/hep.20282
   Matarese G, 2005, J IMMUNOL, V174, P3137, DOI 10.4049/jimmunol.174.6.3137
   Matsusue K, 2003, J CLIN INVEST, V111, P737, DOI 10.1172/JCI200317223
   McAllister SD, 2002, PROSTAG LEUKOTR ESS, V66, P161, DOI 10.1054/plef.2001.0344
   Mendez-Sanchez N, 2007, LIVER INT, V27, P215, DOI 10.1111/j.1478-3231.2006.01401.x
   Miele L, 2008, GASTROENTEROLOGY, V135, P282, DOI 10.1053/j.gastro.2008.04.004
   Mitro N, 2007, NATURE, V445, P219, DOI 10.1038/nature05449
   Musso G, 2005, HEPATOLOGY, V42, P1175, DOI 10.1002/hep.20896
   Musso G, 2003, HEPATOLOGY, V37, P909, DOI 10.1053/jhep.2003.50132
   Musso G, 2009, PROG LIPID RES, V48, P1, DOI 10.1016/j.plipres.2008.08.001
   Musso G, 2008, HEPATOLOGY, V47, P1167, DOI 10.1002/hep.22142
   Nair S, 2001, AM J GASTROENTEROL, V96, P1200, DOI 10.1111/j.1572-0241.2001.03702.x
   Namikawa C, 2004, J HEPATOL, V40, P781, DOI 10.1016/j.jhep.2004.01.028
   NANJI AA, 1994, P SOC EXP BIOL MED, V205, P243
   Nieto N, 2006, HEPATOLOGY, V44, P1487, DOI 10.1002/hep.21427
   Nobili V, 2006, EUR J ENDOCRINOL, V155, P735, DOI 10.1530/eje.1.02288
   Nocito A, 2007, GASTROENTEROLOGY, V133, P608, DOI 10.1053/j.gastro.2007.05.019
   Ohishi T, 2001, HEPATOL RES, V21, P147, DOI 10.1016/S1386-6346(01)00102-4
   Osei-Hyiaman D, 2005, J CLIN INVEST, V115, P1298, DOI 10.1172/JCI200523057
   Ouchi N, 2000, CIRCULATION, V102, P1296, DOI 10.1161/01.CIR.102.11.1296
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Pacher P, 2006, PHARMACOL REV, V58, P389, DOI 10.1124/pr.58.3.2
   Palmer CNA, 1998, MOL PHARMACOL, V53, P14, DOI 10.1124/mol.53.1.14
   PALMER M, 1990, GASTROENTEROLOGY, V99, P1408, DOI 10.1016/0016-5085(90)91169-7
   Paradis V, 2001, HEPATOLOGY, V34, P738, DOI 10.1053/jhep.2001.28055
   Park SH, 2007, J AM COLL NUTR, V26, P321, DOI 10.1080/07315724.2007.10719618
   Pérez-Carreras M, 2003, HEPATOLOGY, V38, P999, DOI 10.1053/jhep.2003.50398
   Pertwee RG, 1999, CURR MED CHEM, V6, P635
   Peters JM, 1996, MOL PHARMACOL, V50, P67
   Petta S, 2008, HEPATOLOGY, V48, P28, DOI 10.1002/hep.22316
   Pfützner A, 2005, HORM METAB RES, V37, P510, DOI 10.1055/s-870320
   Piomelli D, 2000, TRENDS PHARMACOL SCI, V21, P218, DOI 10.1016/S0165-6147(00)01482-6
   Pirola L, 2004, DIABETOLOGIA, V47, P170, DOI 10.1007/s00125-003-1313-3
   Poniachik J, 2006, CYTOKINE, V33, P252, DOI 10.1016/j.cyto.2006.02.006
   Puri P, 2007, HEPATOLOGY, V46, P1081, DOI 10.1002/hep.21763
   Ratziu V, 2000, GASTROENTEROLOGY, V118, P1117, DOI 10.1016/S0016-5085(00)70364-7
   Reaven GM, 2005, CLIN CHEM, V51, P931, DOI 10.1373/clinchem.2005.048611
   Reddy JK, 2001, ANNU REV NUTR, V21, P193, DOI 10.1146/annurev.nutr.21.1.193
   REDDY JK, 1994, ANNU REV NUTR, V14, P343, DOI 10.1146/annurev.nu.14.070194.002015
   Rivera CA, 2007, J HEPATOL, V47, P571, DOI 10.1016/j.jhep.2007.04.019
   Romeo S, 2008, NAT GENET, V40, P1461, DOI 10.1038/ng.257
   Ronti T, 2006, CLIN ENDOCRINOL, V64, P355, DOI 10.1111/j.1365-2265.2006.02474.x
   Sabaté JM, 2008, OBES SURG, V18, P371, DOI 10.1007/s11695-007-9398-2
   Sahai A, 2004, AM J PHYSIOL-GASTR L, V287, pG1035, DOI 10.1152/ajpgi.00199.2004
   Sanyal AJ, 2001, GASTROENTEROLOGY, V120, P1183, DOI 10.1053/gast.2001.23256
   Sanyal Arun J, 2002, Gastroenterology, V123, P1705, DOI 10.1053/gast.2002.36572
   Satapathy SK, 2007, J GASTROEN HEPATOL, V22, P634, DOI 10.1111/j.1440-1746.2006.04756.x
   Scheen AJ, 2008, J NEUROENDOCRINOL, V20, P139, DOI 10.1111/j.1365-2826.2008.01681.x
   SCHOONJANS K, 1995, J BIOL CHEM, V270, P19269, DOI 10.1074/jbc.270.33.19269
   Schwabe RF, 2006, GASTROENTEROLOGY, V130, P1886, DOI 10.1053/j.gastro.2006.01.038
   Seki S, 2002, J HEPATOL, V37, P56, DOI 10.1016/S0168-8278(02)00073-9
   Semple RK, 2006, J CLIN INVEST, V116, P581, DOI 10.1172/JCI28003
   Seo JA, 2008, CLIN ENDOCRINOL, V68, P555, DOI 10.1111/j.1365-2265.2007.03072.x
   Shimada M, 2007, AM J GASTROENTEROL, V102, P1931, DOI 10.1111/j.1572-0241.2007.01322.x
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Solga SF, 2008, J CLIN GASTROENTEROL, V42, P1117, DOI 10.1097/MCG.0b013e31816d920c
   Solinas G, 2006, P NATL ACAD SCI USA, V103, P16454, DOI 10.1073/pnas.0607626103
   Sowers JR, 2002, NEW ENGL J MED, V346, P1999, DOI 10.1056/NEJMe020054
   Stefan N, 2007, DIABETES CARE, V30, P1173, DOI 10.2337/dc06-2342
   Sumida Y, 2003, J HEPATOL, V38, P32, DOI 10.1016/S0168-8278(02)00331-8
   Suzuki A, 2005, J HEPATOL, V43, P1060, DOI 10.1016/j.jhep.2005.06.008
   Svegliati-Baroni G, 1999, HEPATOLOGY, V29, P1743, DOI 10.1002/hep.510290632
   Targher G, 2007, NUTR METAB CARDIOVAS, V17, P517, DOI 10.1016/j.numecd.2006.04.002
   Taylor R, 2008, DIABETOLOGIA, V51, P1781, DOI 10.1007/s00125-008-1116-7
   Teixeira-Clerc F, 2006, NAT MED, V12, P671, DOI 10.1038/nm1421
   Tendler D, 2007, DIGEST DIS SCI, V52, P589, DOI 10.1007/s10620-006-9433-5
   Tetri LH, 2008, AM J PHYSIOL-GASTR L, V295, pG987, DOI 10.1152/ajpgi.90272.2008
   Thomas EL, 2005, GUT, V54, P122, DOI 10.1136/gut.2003.036566
   Tilg H, 2006, GASTROENTEROLOGY, V131, P934, DOI 10.1053/j.gastro.2006.05.054
   Tomita K, 2006, GUT, V55, P415, DOI 10.1136/gut.2005.071118
   Tomita K, 2008, HEPATOLOGY, V48, P458, DOI 10.1002/hep.22365
   TONTONOZ P, 1994, CELL, V79, P1147, DOI 10.1016/0092-8674(94)90006-X
   Toshimitsu K, 2007, NUTRITION, V23, P46, DOI 10.1016/j.nut.2006.09.004
   Ueki K, 2004, MOL CELL BIOL, V24, P5434, DOI 10.1128/MCB.24.12.5434-5446.2004
   Ueki K, 2004, P NATL ACAD SCI USA, V101, P10422, DOI 10.1073/pnas.0402511101
   Ueki M, 2006, J GASTROENTEROL, V41, P996, DOI 10.1007/s00535-006-1891-1
   Ueno T, 1997, J HEPATOL, V27, P103, DOI 10.1016/S0168-8278(97)80287-5
   Unger RH, 2002, ANNU REV MED, V53, P319, DOI 10.1146/annurev.med.53.082901.104057
   Uygun A, 2000, AM J GASTROENTEROL, V95, P3584
   van der Poorten D, 2008, HEPATOLOGY, V48, P449, DOI 10.1002/hep.22350
   Virkamäki A, 1999, J CLIN INVEST, V103, P931, DOI 10.1172/JCI6609
   Walker JM, 2002, CHEM PHYS LIPIDS, V121, P159, DOI 10.1016/S0009-3084(02)00152-4
   Wang D, 2006, ENDOCRINOLOGY, V147, P943, DOI 10.1210/en.2005-0570
   WANLESS IR, 1990, HEPATOLOGY, V12, P1106, DOI 10.1002/hep.1840120505
   Wei Y, 2008, J HEPATOL, V49, P417, DOI 10.1016/j.jhep.2008.03.018
   Wieckowska A, 2006, HEPATOLOGY, V44, P27, DOI 10.1002/hep.21223
   Wolf AM, 2004, BIOCHEM BIOPH RES CO, V323, P630, DOI 10.1016/j.bbrc.2004.08.145
   Woods SC, 2007, AM J MED, V120, pS9, DOI 10.1016/j.amjmed.2006.11.013
   Yamaguchi K, 2007, HEPATOLOGY, V45, P1366, DOI 10.1002/hep.21655
   Yang Q, 2005, NATURE, V436, P356, DOI 10.1038/nature03711
   Yang SQ, 2000, ARCH BIOCHEM BIOPHYS, V378, P259, DOI 10.1006/abbi.2000.1829
   Yesilova Z, 2005, AM J GASTROENTEROL, V100, P850, DOI 10.1111/j.1572-0241.2005.41500.x
   Yokohama S, 2004, HEPATOLOGY, V40, P1222, DOI 10.1002/hep.20420
   Zhou J, 2008, GASTROENTEROLOGY, V134, P556, DOI 10.1053/j.gastro.2007.11.037
NR 208
TC 212
Z9 237
U1 7
U2 79
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1590-8658
EI 1878-3562
J9 DIGEST LIVER DIS
JI Dig. Liver Dis.
PD SEP
PY 2009
VL 41
IS 9
BP 615
EP 625
DI 10.1016/j.dld.2009.01.004
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 493JG
UT WOS:000269732100001
PM 19223251
DA 2025-06-11
ER

PT J
AU Charlton, RA
   McQuaid, GA
   Bishop, L
   Wallace, GL
AF Charlton, Rebecca A.
   McQuaid, Goldie A.
   Bishop, Lauren
   Wallace, Gregory L.
TI Cardiovascular risk and emotion regulation contribute to depression
   symptomatology in middle-aged and older autistic adults
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Ageing; Autism; Cardiovascular risk factors; Depression; Emotion
   regulation; Later-life; Physical health
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; EXECUTIVE FUNCTION; SPECTRUM
   DISORDER; MAJOR DEPRESSION; VASCULAR RISK; YOUNG-ADULTS; HEALTH;
   DISEASE; ASSOCIATIONS
AB Background: Cardiovascular risk factors (CVRF) and executive function difficulties increase during later-life and are associated with depression symptoms among non-autistic older people. These associations, however, have not yet been explored among middle-aged and older autistic people.Methods: Using data collected via Simons Foundation Powering Autism Research (SPARK), Research Match, we examined the frequency of CVRF, and associations between CVRF, executive function and depression symptoms in 387 middle-aged and older autistic people (aged 40-83 years).Results: Autistic adults reported high rates of CVRF (two, 28.9%; three or more, 23.2%). Rates of high cholesterol and obesity were greater among middle-aged and older autistic adults compared to the general population. CVRF, age, and emotion regulation (but not inhibitory control), were significantly associated with depression symptoms in middle-aged and older autistic adults.Conclusions: CVRF occur at high rates in middle-aged and older autistic adults, and it is important that healthcare providers monitor risk factors in order to implement preventative strategies. CVRF are associated with depressive symptoms among middle-aged and older autistic adults, but may not be as important as difficulties with emotion regulation.
C1 [Charlton, Rebecca A.] Goldsmiths Univ London, Dept Psychol, London, England.
   [McQuaid, Goldie A.] George Mason Univ, Dept Psychol, Fairfax, VA USA.
   [Bishop, Lauren] Univ Wisconsin Madison, Sandra Rosenbaum Sch Social Work, Madison, WI USA.
   [Bishop, Lauren] Univ Wisconsin Madison, Waisman Ctr, Madison, WI USA.
   [Wallace, Gregory L.] George Washington Univ, Dept Speech Language & Hearing Sci, Fairfax, VA USA.
   [Charlton, Rebecca A.] Goldsmiths Univ London, Dept Psychol, London SE14 6NW, England.
C3 University of London; Goldsmiths University London; George Mason
   University; University of Wisconsin System; University of Wisconsin
   Madison; University of Wisconsin System; University of Wisconsin
   Madison; George Washington University; University of London; Goldsmiths
   University London
RP Charlton, RA (corresponding author), Goldsmiths Univ London, Dept Psychol, London SE14 6NW, England.
EM r.charlton@gold.ac.uk
RI Bishop, Lauren/AAH-5691-2021; Wallace, Gregory/H-2158-2018
OI Bishop, Lauren/0000-0003-1269-4129; McQuaid, Goldie/0000-0003-3614-616X;
   Wallace, Gregory/0000-0003-0329-5054
FU George Washington University [11808]; Fulbright Visiting Scholar
   program; Eunice Kennedy Shriver National Institute of Child Health and
   Human Development [U54HD090256]
FX The author (s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: The George
   Washington University start-up funds to Gregory Wallace; Autism Speaks
   (Grant number: 11808) to Goldie McQuaid; the Fulbright Visiting Scholar
   program to Rebecca Charlton; and the Eunice Kennedy Shriver National
   Institute of Child Health and Human Development (Grant number:
   U54HD090256) to the Waisman Center.
CR Akbaraly TN, 2009, DIABETES CARE, V32, P499, DOI 10.2337/dc08-1358
   Alexopoulos GS, 2019, TRANSL PSYCHIAT, V9, DOI 10.1038/s41398-019-0514-6
   Alexopoulos GS, 1997, ARCH GEN PSYCHIAT, V54, P915
   Alexopoulos GS, 2005, BIOL PSYCHIAT, V58, P204, DOI 10.1016/j.biopsych.2005.04.024
   Almeida OP, 2009, AM J GERIAT PSYCHIAT, V17, P889, DOI 10.1097/JGP.0b013e3181b047e3
   Arnold SRC, 2020, J AUTISM DEV DISORD, V50, P2217, DOI 10.1007/s10803-019-03947-9
   Barch DM, 2012, AM J GERIAT PSYCHIAT, V20, P682, DOI 10.1097/JGP.0b013e318246b6cb
   Barkley R. A., 2011, Barkley Deficits in Executive Functioning Scale (BDEFS for Adults)
   Barkley R.A., 2014, Handbook of executive functioning, P245, DOI [10.1007/978-1-4614-8106-515, DOI 10.1007/978-1-4614-8106-515, DOI 10.1007/978-1-4614-8106-5_15]
   Barkley RA, 2011, J PSYCHOPATHOL BEHAV, V33, P137, DOI 10.1007/s10862-011-9217-x
   Bhalla R. K., 2011, B C MED J, V53, P357
   Bishop-Fitzpatrick L, 2019, RES AUTISM SPECT DIS, V63, P34, DOI 10.1016/j.rasd.2019.01.001
   Bishop-Fitzpatrick L, 2018, AUTISM RES, V11, P1120, DOI 10.1002/aur.1960
   Butnoriene J, 2018, BMC PSYCHIATRY, V18, DOI 10.1186/s12888-017-1576-8
   Cassidy SA, 2018, AUTISM RES, V11, P738, DOI 10.1002/aur.1922
   Charlton RA, 2006, NEUROLOGY, V66, P217, DOI 10.1212/01.wnl.0000194256.15247.83
   Charlton RA, 2014, AM J GERIAT PSYCHIAT, V22, P936, DOI 10.1016/j.jagp.2013.01.074
   Conner CM, 2021, AUTISM RES, V14, P169, DOI 10.1002/aur.2450
   Conry MC, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-692
   Corp I. B. M., 2020, IBM SPSS STAT WIND V
   Croen LA, 2015, AUTISM, V19, P814, DOI 10.1177/1362361315577517
   Daviglus ML, 2003, ARCH INTERN MED, V163, P2460, DOI 10.1001/archinte.163.20.2460
   Dietz PM, 2020, J AUTISM DEV DISORD, V50, P4258, DOI 10.1007/s10803-020-04494-4
   Dijkhuis RR, 2017, AUTISM, V21, P896, DOI 10.1177/1362361316655525
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   Feliciano P, 2018, NEURON, V97, P488, DOI 10.1016/j.neuron.2018.01.015
   Foley DL, 2010, TWIN RES HUM GENET, V13, P347, DOI 10.1375/twin.13.4.347
   Fombonne E, 2022, J AUTISM DEV DISORD, V52, P3383, DOI 10.1007/s10803-021-05218-y
   Hajjar I, 2009, J GERONTOL A-BIOL, V64, P994, DOI 10.1093/gerona/glp075
   Hand BN, 2020, AUTISM, V24, P755, DOI 10.1177/1362361319890793
   Happé FG, 2016, J AUTISM DEV DISORD, V46, P3469, DOI 10.1007/s10803-016-2886-2
   Heun R, 2005, EUR PSYCHIAT, V20, P199, DOI 10.1016/j.eurpsy.2004.09.036
   Isaacowitz DM, 2018, PSYCHOL AGING, V33, P361, DOI 10.1037/pag0000231
   Johnston K, 2019, J AUTISM DEV DISORD, V49, P4181, DOI 10.1007/s10803-019-04133-7
   Joormann J, 2016, BEHAV RES THER, V86, P35, DOI 10.1016/j.brat.2016.07.007
   Katz R, 2010, AM J GERIAT PSYCHIAT, V18, P1017, DOI 10.1097/JGP.0b013e3181d695f2
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Lamar M, 2015, CURR ALZHEIMER RES, V12, P640, DOI 10.2174/1567205012666150701102325
   Leritz EC, 2011, CURR CARDIOVASC RISK, V5, P407, DOI 10.1007/s12170-011-0189-x
   Mahmood SS, 2014, LANCET, V383, P999, DOI 10.1016/S0140-6736(13)61752-3
   Manning KJ, 2018, J AM GERIATR SOC, V66, pS17, DOI 10.1111/jgs.15353
   Marazziti D, 2014, CNS SPECTRUMS, V19, P293, DOI 10.1017/S1092852913000667
   Mason D, 2022, AUTISM ADULTHOOD, V4, P164, DOI 10.1089/aut.2021.0041
   Mason D, 2018, AUTISM RES, V11, P1138, DOI 10.1002/aur.1965
   Mather M, 2012, ANN NY ACAD SCI, V1251, P33, DOI 10.1111/j.1749-6632.2012.06471.x
   Mazefsky CA, 2013, J AM ACAD CHILD PSY, V52, P679, DOI 10.1016/j.jaac.2013.05.006
   Morie KP, 2019, J AUTISM DEV DISORD, V49, P2935, DOI 10.1007/s10803-019-04020-1
   Moulton CD, 2015, LANCET DIABETES ENDO, V3, P461, DOI 10.1016/S2213-8587(15)00134-5
   Nishtala A, 2014, ALZ DIS ASSOC DIS, V28, P16, DOI 10.1097/WAD.0b013e3182a715bc
   Olaya B, 2019, BMC GERIATR, V19, DOI 10.1186/s12877-019-1350-5
   Pause C., 2021, Multicultural Responsiveness in Counselling and Psychology, DOI DOI 10.1007/978-3-030-55427-9_9
   REAVEN GM, 1993, ANNU REV MED, V44, P121, DOI 10.1146/annurev.med.44.1.121
   Repousi N, 2018, J AFFECT DISORDERS, V237, P56, DOI 10.1016/j.jad.2018.04.102
   Román GC, 2002, LANCET NEUROL, V1, P426, DOI 10.1016/S1474-4422(02)00190-4
   Smoski MJ, 2014, AM J GERIAT PSYCHIAT, V22, P898, DOI 10.1016/j.jagp.2013.01.070
   Tournoy J, 2010, DIABETES-METAB RES, V26, P668, DOI 10.1002/dmrr.1144
   Wallace GL, 2016, J AUTISM DEV DISORD, V46, P1071, DOI 10.1007/s10803-015-2655-7
NR 57
TC 4
Z9 4
U1 1
U2 8
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD MAR
PY 2023
VL 101
AR 102089
DI 10.1016/j.rasd.2022.102089
EA DEC 2022
PG 9
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
WE Social Science Citation Index (SSCI)
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 7O4CJ
UT WOS:000907973200001
OA Green Submitted, Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Jiménez-Osorio, AS
   González-Reyes, S
   Pedraza-Chaverri, J
AF Sarai Jimenez-Osorio, Angelica
   Gonzalez-Reyes, Susana
   Pedraza-Chaverri, Jose
TI Natural Nrf2 activators in diabetes
SO CLINICA CHIMICA ACTA
LA English
DT Review
DE Prediabetes; Diabetes; Nrf2; Curcumin; Sulforaphane; Resveratrol;
   Vitamin D; Heme-oxygenase-1; Glutathione reductase; Glutathione
   peroxidase; Gamma-glutamate-cysteine ligase
ID VITAMIN-D SUPPLEMENTATION; LIFE-STYLE INTERVENTION; IMPAIRED
   GLUCOSE-TOLERANCE; INDUCED INSULIN-RESISTANCE; UP-REGULATES NRF2;
   OXIDATIVE STRESS; DOUBLE-BLIND; RESVERATROL SUPPLEMENTATION; ENDOTHELIAL
   FUNCTION; METABOLIC SYNDROME
AB Prediabetes and diabetes are rising worldwide. Control of blood glucose is crucial to prevent or delay diabetic complications that frequently result in increased morbidity and mortality. Most strategies include medical treatment and changes in lifestyle and diet. Some nutraceutical compounds have been recognized as adjuvants in diabetes control. Many of them can activate the nuclear factor (erythroid-derived 2)-like 2 (Nrf2), which has been recognized as a master regulator of the antioxidant response. Recent studies have described the role of Nrf2 in obesity, metabolic syndrome, nephropathy, retinopathy and neuropathy, where its activation prevents the development of diabetes and its complications. It has been demonstrated that natural compounds derived from plants, vegetables, fungi and micronutrients (such as curcumin, sulforaphane, resveratrol and vitamin D among others) can activate Nrf2 and, thus, promote antioxidant pathways to mitigate oxidative stress and hyperglycemic damage. The role of some natural Nrf2 activators and its effect in diabetes is discussed. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Sarai Jimenez-Osorio, Angelica; Gonzalez-Reyes, Susana; Pedraza-Chaverri, Jose] Univ Nacl Autonoma Mexico, Dept Biol, Fac Chem, Univ City 04510, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico
RP Pedraza-Chaverri, J (corresponding author), Univ Nacl Autonoma Mexico, Dept Biol, Fac Chem, Univ City 04510, DF, Mexico.
EM joas17@hotmail.com; suxan05@gmail.com; pedraza@unam.mx
RI Jiménez-Osorio, Angélica/X-7119-2019
OI Jimenez-Osorio, Angelica Sarai/0000-0001-5108-0205; Gonzalez-Reyes,
   Susana/0000-0003-2260-8415
FU Consejo Nacional de Ciencia y Tecnologia (CONACYT)
   [SALUD-2013-01-201519, 252008]
FX This projeet was supported by Consejo Nacional de Ciencia y Tecnologia
   (CONACYT, Grant numbers SALUD-2013-01-201519 and 252008).
CR Ackermann RT, 2008, AM J PREV MED, V35, P357, DOI 10.1016/j.amepre.2008.06.035
   Alibasic Esad, 2013, Mater Sociomed, V25, P80, DOI 10.5455/msm.2013.25.80-82
   Alkharfy KM, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-113
   Amer Diabet Assoc, 2014, DIABETES CARE, V37, pS14, DOI 10.2337/dc14-S014
   Ang SH, 2015, CLIN CHIM ACTA, V439, P202, DOI 10.1016/j.cca.2014.10.019
   [Anonymous], EVID BASED COMPLEMEN
   [Anonymous], 2013, DIABETES ATLAS, V6th
   [Anonymous], J DIABETES
   [Anonymous], DEF DAIGN DIAB MELL
   [Anonymous], DRUGS
   Arambasic J, 2013, EUR J NUTR, V52, P1461, DOI 10.1007/s00394-012-0452-z
   Avenell A, 2009, AGE AGEING, V38, P606, DOI 10.1093/ageing/afp109
   Babu PS, 1998, MOL CELL BIOCHEM, V181, P87, DOI 10.1023/A:1006821828706
   Bahadoran Z, 2013, J DIABETES METAB DIS, V12, DOI 10.1186/2251-6581-12-43
   Bahadoran Z, 2013, J MED FOOD, V16, P375, DOI 10.1089/jmf.2012.2559
   Bahadoran Z, 2012, INT J FOOD SCI NUTR, V63, P767, DOI 10.3109/09637486.2012.665043
   Baird L, 2011, ARCH TOXICOL, V85, P241, DOI 10.1007/s00204-011-0674-5
   Bhatt JK, 2012, NUTR RES, V32, P537, DOI 10.1016/j.nutres.2012.06.003
   Bitar MS, 2011, AM J PHYSIOL-ENDOC M, V301, pE1119, DOI 10.1152/ajpendo.00047.2011
   Blonde L, 2009, DIABETES OBES METAB, V11, P623, DOI 10.1111/j.1463-1326.2009.01060.x
   BOHAN E M, 1961, Del Med J, V33, P297
   Boyle JP, 2010, POPUL HEALTH METR, V8, DOI 10.1186/1478-7954-8-29
   Bray GA, 2009, LANCET, V374, P1677, DOI 10.1016/S0140-6736(09)61457-4
   Breslavsky A, 2013, CLIN NUTR, V32, P970, DOI 10.1016/j.clnu.2013.01.020
   Ceriello A, 2008, DIABETES, V57, P1349, DOI 10.2337/db08-0063
   Chang WC, 2015, MOLECULES, V20, P2786, DOI 10.3390/molecules20022786
   Cheng AS, 2012, J AGR FOOD CHEM, V60, P9180, DOI 10.1021/jf302831d
   Chiasson JL, 2003, JAMA-J AM MED ASSOC, V290, P486, DOI 10.1001/jama.290.4.486
   Chiu J, 2009, NUTRITION, V25, P964, DOI 10.1016/j.nut.2008.12.007
   Choi KM, 2014, J NUTR BIOCHEM, V25, P201, DOI 10.1016/j.jnutbio.2013.10.007
   Chuengsamarn S, 2014, J NUTR BIOCHEM, V25, P144, DOI 10.1016/j.jnutbio.2013.09.013
   Chuengsamarn S, 2012, DIABETES CARE, V35, P2121, DOI 10.2337/dc12-0116
   Clark AL, 2014, DIABETES, V63, P1457, DOI 10.2337/db14-0108
   Davidson MB, 2013, DIABETES CARE, V36, P260, DOI 10.2337/dc12-1204
   de Boer IH, 2008, DIABETES CARE, V31, P701, DOI 10.2337/dc07-1829
   Di Cesar DJ, 2006, DIABETES CARE, V29, P174, DOI 10.2337/diacare.29.1.174
   Esatbeyoglu T, 2012, ANGEW CHEM INT EDIT, V51, P5308, DOI 10.1002/anie.201107724
   Evert AB, 2014, DIABETES CARE, V37, pS120, DOI 10.2337/dc14-S120
   Farmer A, 2007, BMJ-BRIT MED J, V335, P132, DOI 10.1136/bmj.39247.447431.BE
   Fiorentino A, 2009, J AGR FOOD CHEM, V57, P4148, DOI 10.1021/jf900210z
   Ganjali S, 2014, SCI WORLD J, DOI 10.1155/2014/898361
   Gao D., 2014, Arch Pharm Res
   Gauthier Bernard, 2014, Can Pharm J (Ott), V147, P45, DOI 10.1177/1715163513506547
   Gujral UP, 2015, DIABETES CARE, V38, P1312, DOI 10.2337/dc15-0032
   Hayes JD, 2014, TRENDS BIOCHEM SCI, V39, P199, DOI 10.1016/j.tibs.2014.02.002
   He HJ, 2012, WORLD J DIABETES, V3, P94, DOI 10.4239/wjd.v3.i5.94
   He XQ, 2009, J MOL CELL CARDIOL, V46, P47, DOI 10.1016/j.yjmcc.2008.10.007
   Herman WH, 2012, DIABETES CARE, V35, P723, DOI 10.2337/dc11-1468
   Holman RR, 2008, NEW ENGL J MED, V359, P1577, DOI 10.1056/NEJMoa0806470
   Hsu WH, 2012, J AGR FOOD CHEM, V60, P1666, DOI 10.1021/jf204327c
   Hsu YY, 2013, TOXICOL APPL PHARM, V272, P787, DOI 10.1016/j.taap.2013.08.008
   Hwang SM, 2012, INT J MOL SCI, V13, P1258, DOI 10.3390/ijms13011258
   Inzucchi SE, 2012, DIABETOLOGIA, V55, P1577, DOI 10.1007/s00125-012-2534-0
   Itoh K, 1997, BIOCHEM BIOPH RES CO, V236, P313, DOI 10.1006/bbrc.1997.6943
   Jiang T, 2010, DIABETES, V59, P850, DOI 10.2337/db09-1342
   Jiménez-Osorio AS, 2014, INT J MOL SCI, V15, P20290, DOI 10.3390/ijms151120290
   Kang KA, 2009, BIOTECHNOL BIOPROC E, V14, P295, DOI 10.1007/s12257-008-0196-z
   Katoh Y, 2005, ARCH BIOCHEM BIOPHYS, V433, P342, DOI 10.1016/j.abb.2004.10.012
   Kawai Y, 2011, J BIOL CHEM, V286, P7629, DOI 10.1074/jbc.M110.208173
   Khajehdehi P, 2011, SCAND J UROL NEPHROL, V45, P365, DOI 10.3109/00365599.2011.585622
   Kim SH, 2010, CARDIOVASC RES, V87, P713, DOI 10.1093/cvr/cvq089
   Knop FK, 2013, DIABETIC MED, V30, P1214, DOI 10.1111/dme.12231
   Knowler William C, 2002, N Engl J Med, V346, P393, DOI 10.1056/NEJMoa012512
   Kobayashi A, 2004, MOL CELL BIOL, V24, P7130, DOI 10.1128/MCB.24.16.7130-7139.2004
   Kowluru RA, 2003, FREE RADICAL RES, V37, P1169, DOI 10.1080/10715760310001604189
   Kramer CK, 2014, DIABETES CARE, V37, P1116, DOI 10.2337/dc13-2591
   Kumar A, 2013, CURR MED CHEM, V20, P4640, DOI 10.2174/09298673113209990151
   Lee BH, 2013, FREE RADICAL BIO MED, V60, P7, DOI 10.1016/j.freeradbiomed.2013.01.030
   Lee BH, 2012, FREE RADICAL BIO MED, V53, P2008, DOI 10.1016/j.freeradbiomed.2012.09.025
   Lee CC, 2014, PHARM BIOL, V52, P628, DOI 10.3109/13880209.2013.860555
   Lee CL, 2010, J AGR FOOD CHEM, V58, P9013, DOI 10.1021/jf101982v
   Lee YJ, 2015, CLIN EXP DERMATOL, V40, P192, DOI 10.1111/ced.12487
   Ley SH, 2014, LANCET, V383, P1999, DOI 10.1016/S0140-6736(14)60613-9
   Li H, 2011, CELL SIGNAL, V23, P1625, DOI 10.1016/j.cellsig.2011.05.016
   Liang K, 2014, DIABETES TECHNOL THE, V16, P853, DOI 10.1089/dia.2014.0157
   Lindström J, 2006, LANCET, V368, P1673, DOI 10.1016/S0140-6736(06)69701-8
   Lipska KJ, 2011, DIABETES CARE, V34, P1431, DOI 10.2337/dc10-2361
   Liu TS, 2014, J ENDOCRINOL INVEST, V37, P645, DOI 10.1007/s40618-014-0086-5
   Lowe LP, 1997, DIABETES CARE, V20, P163, DOI 10.2337/diacare.20.2.163
   Maruthur NM, 2013, J GEN INTERN MED, V28, P1629, DOI 10.1007/s11606-013-2548-4
   Masjedi F, 2013, IRAN J PHARM RES, V12, P325
   MATHEW PT, 1973, INDIAN J BIOCHEM BIO, V10, P209
   Méndez-del Villar M, 2014, METAB SYNDR RELAT D, V12, P497, DOI 10.1089/met.2014.0082
   Mitri J, 2011, AM J CLIN NUTR, V94, P486, DOI 10.3945/ajcn.111.011684
   Mohammadi A, 2013, PHYTOTHER RES, V27, P374, DOI 10.1002/ptr.4715
   Monnier L, 2006, JAMA-J AM MED ASSOC, V295, P1681, DOI 10.1001/jama.295.14.1681
   Motohashi H, 2002, GENE, V294, P1, DOI 10.1016/S0378-1119(02)00788-6
   Mozzini C, 2015, FREE RADICAL RES, V49, P244, DOI 10.3109/10715762.2014.997229
   Mukai N, 2014, J DIABETES INVEST, V5, P162, DOI 10.1111/jdi.12136
   Na LX, 2013, MOL NUTR FOOD RES, V57, P1569, DOI 10.1002/mnfr.201200131
   Nakai K, 2014, AM J HYPERTENS, V27, P586, DOI 10.1093/ajh/hpt160
   Narayan KMV, 2002, BMJ-BRIT MED J, V325, P403, DOI 10.1136/bmj.325.7361.403
   Negrette-Guzmán M, 2013, FREE RADICAL BIO MED, V65, P1078, DOI 10.1016/j.freeradbiomed.2013.08.182
   Orchard TJ, 2005, ANN INTERN MED, V142, P611, DOI 10.7326/0003-4819-142-8-200504190-00009
   Padiya R, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094228
   Padiya R, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-53
   Palsamy P, 2011, BBA-MOL BASIS DIS, V1812, P719, DOI 10.1016/j.bbadis.2011.03.008
   Panahi Y, 2014, COMPLEMENT THER MED, V22, P851, DOI 10.1016/j.ctim.2014.07.006
   Patakova P, 2013, J IND MICROBIOL BIOT, V40, P169, DOI 10.1007/s10295-012-1216-8
   Pi JB, 2010, TOXICOL APPL PHARM, V244, P77, DOI 10.1016/j.taap.2009.05.025
   Polonsky WH, 2011, DIABETES CARE, V34, P262, DOI 10.2337/dc10-1732
   Poulsen MM, 2013, DIABETES, V62, P1186, DOI 10.2337/db12-0975
   Pugazhenthi S, 2007, AM J PHYSIOL-ENDOC M, V293, pE645, DOI 10.1152/ajpendo.00111.2007
   Ramprasath T, 2012, BIOCHEM BIOPH RES CO, V428, P389, DOI 10.1016/j.bbrc.2012.10.064
   Rivera-Mancía S, 2015, EUR J PHARMACOL, V756, P30, DOI 10.1016/j.ejphar.2015.02.045
   Ryu OH, 2014, KOREAN J INTERN MED, V29, P620
   Sadi G, 2014, MOL CELL BIOCHEM, V393, P111, DOI 10.1007/s11010-014-2051-1
   Sahin K, 2012, BIOL TRACE ELEM RES, V150, P291, DOI 10.1007/s12011-012-9475-9
   Salehpour A, 2013, DIABETIC MED, V30, P1477, DOI 10.1111/dme.12273
   Shakibaei M, 2009, MOL NUTR FOOD RES, V53, P115, DOI 10.1002/mnfr.200800148
   SHAMOON H, 1993, NEW ENGL J MED, V329, P977, DOI 10.1056/NEJM199307293290502
   Shang GG, 2015, J NUTR BIOCHEM, V26, P596, DOI 10.1016/j.jnutbio.2014.12.008
   Sobenin IA, 2008, ACTA DIABETOL, V45, P1, DOI 10.1007/s00592-007-0011-x
   Song MY, 2009, TOXICOL APPL PHARM, V235, P57, DOI 10.1016/j.taap.2008.11.007
   Soric MM, 2012, J DIABETES, V4, P104, DOI 10.1111/j.1753-0407.2011.00164.x
   Sorkin JD, 2014, J NUTR, V144, P734, DOI 10.3945/jn.114.190660
   Sugden JA, 2008, DIABETIC MED, V25, P320, DOI 10.1111/j.1464-5491.2007.02360.x
   Surh YJ, 2008, PLANTA MED, V74, P1526, DOI 10.1055/s-0028-1088302
   Szkudelski T, 2011, ANN NY ACAD SCI, V1215, P34, DOI 10.1111/j.1749-6632.2010.05844.x
   Tan Y, 2011, DIABETES, V60, P625, DOI 10.2337/db10-1164
   Trujillo J, 2014, ARCH PHARM, V347, P873, DOI 10.1002/ardp.201400266
   Tsai CY, 2013, INT J CARDIOL, V168, P1286, DOI 10.1016/j.ijcard.2012.12.004
   Turner RC, 1998, LANCET, V352, P837, DOI 10.1016/s0140-6736(98)07019-6
   Turpaev KT, 2013, BIOCHEMISTRY-MOSCOW+, V78, P111, DOI 10.1134/S0006297913020016
   Ungvari Z, 2011, AM J PHYSIOL-HEART C, V300, pH1133, DOI 10.1152/ajpheart.00402.2010
   Uruno A, 2013, MOL CELL BIOL, V33, P2996, DOI 10.1128/MCB.00225-13
   Velmurugan GV, 2013, CARDIOVASC RES, V100, P143, DOI 10.1093/cvr/cvt125
   von Hurst PR, 2010, BRIT J NUTR, V103, P549, DOI 10.1017/S0007114509992017
   Wallia A, 2014, JAMA-J AM MED ASSOC, V311, P2315, DOI 10.1001/jama.2014.5951
   Wang LK, 2014, INT J MOL SCI, V15, P16226, DOI 10.3390/ijms150916226
   Wang X, 2013, MOL CELL ENDOCRINOL, V376, P70, DOI 10.1016/j.mce.2013.06.014
   Wang X, 2011, TOXICOL IN VITRO, V25, P839, DOI 10.1016/j.tiv.2011.02.004
   Wang YG, 2014, AM J PHYSIOL-ENDOC M, V307, pE14, DOI 10.1152/ajpendo.00702.2013
   Weisberg SP, 2008, ENDOCRINOLOGY, V149, P3549, DOI 10.1210/en.2008-0262
   Wise Jacqui, 2014, BMJ, V348, pg3791, DOI 10.1136/bmj.g3791
   Wolf AM, 2004, DIABETES CARE, V27, P1570, DOI 10.2337/diacare.27.7.1570
   Xue MZ, 2008, DIABETES, V57, P2809, DOI 10.2337/db06-1003
   Yang Y, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/145641
   Yiu YF, 2013, ATHEROSCLEROSIS, V227, P140, DOI 10.1016/j.atherosclerosis.2012.12.013
   Yoh K, 2008, GENES CELLS, V13, P1159, DOI 10.1111/j.1365-2443.2008.01234.x
   Zao ZF, 2013, INT J OPHTHALMOL-CHI, V6, P422, DOI 10.3980/j.issn.2222-3959.2013.04.02
   Zeymer U, 2004, EUR J CARDIOV PREV R, V11, P412, DOI 10.1097/00149831-200410000-00009
   Zhang DD, 2004, MOL CELL BIOL, V24, P10941, DOI 10.1128/MCB.24.24.10941-10953.2004
   Zhang DW, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/636053
   Zhang XL, 2015, MOL MED REP, V12, P1347, DOI 10.3892/mmr.2015.3556
   Zhang XL, 2014, BIOL TRACE ELEM RES, V158, P259, DOI 10.1007/s12011-014-9922-x
   Zhang ZG, 2014, J MOL CELL CARDIOL, V77, P42, DOI 10.1016/j.yjmcc.2014.09.022
   Zheng HT, 2011, DIABETES, V60, P3055, DOI 10.2337/db11-0807
NR 148
TC 114
Z9 121
U1 1
U2 65
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD AUG 25
PY 2015
VL 448
BP 182
EP 192
DI 10.1016/j.cca.2015.07.009
PG 11
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA CQ8OZ
UT WOS:000360869300030
PM 26165427
DA 2025-06-11
ER

PT J
AU Assies, J
   Mocking, RJT
   Lok, A
   Koeter, MWJ
   Bockting, CLH
   Visser, I
   Pouwer, F
   Ruhé, HG
   Schene, AH
AF Assies, Johanna
   Mocking, Roel J. T.
   Lok, Anja
   Koeter, Maarten W. J.
   Bockting, Claudi L. H.
   Visser, Ieke
   Pouwer, Francois
   Ruhe, Henricus G.
   Schene, Aart H.
TI Erythrocyte fatty acid profiles and plasma homocysteine, folate and
   vitamin B6 and B12 in recurrent depression:
   Implications for co-morbidity with cardiovascular disease
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Polyunsaturated fatty acids; Chain length; Unsaturation index;
   Peroxidation index; One-carbon cycle; Cardiovascular disease; Oxidative
   stress
ID CORONARY-HEART-DISEASE; DOCOSAHEXAENOIC ACID; OXIDATIVE STRESS;
   METABOLIC SYNDROME; N-3; OMEGA-3-FATTY-ACIDS; DISORDER; RISK;
   HYPERHOMOCYSTEINEMIA; POLYMORPHISM
AB Oxidative stress induced interactions between fatty acid (FA) and one-carbon metabolism may be involved in co-occurrence of major depressive disorder (MDD) and cardiovascular disease (CVD), which have been scarcely studied together. In 137 recurrent MDD-patients vs. 73 age- and sex-matched healthy controls, we simultaneously measured key components of one-carbon metabolism in plasma (homocysteine, folate, vitamins B-6 and B-12), and of FA-metabolism in red blood cell membranes [main polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA), docosahexaenoic acid (DMA), and arachidonic acid (AA) and structural FA-indices (chain length, unsaturation, peroxidation)]. Results show significant positive associations of folate with EPA, DHA, and the peroxidation index, which were similar in patients and controls. After correction for confounders, these associations were lost except for EPA. Associations between B-vitamins and FA-parameters were non-significant, but also similar in patients and controls. Homocysteine and DHA were significantly less negatively associated in patients than in controls. In conclusion, these data indicate similarities but also differences in associations between parameters of one-carbon and FA-metabolism in recurrent MDD patients vs. controls, which may reflect differences in handling of oxidative stress. Further research should test the consequences of these differences, particularly the premature development of CVD in MDD. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Assies, Johanna; Mocking, Roel J. T.; Lok, Anja; Koeter, Maarten W. J.; Visser, Ieke; Ruhe, Henricus G.; Schene, Aart H.] Univ Amsterdam, Acad Med Ctr, Dept Psychiat, Program Mood Disorders, NL-1105 AZ Amsterdam, Netherlands.
   [Lok, Anja] Arq Psychotrauma Expert Grp, Diemen, Netherlands.
   [Bockting, Claudi L. H.] Univ Groningen, Dept Clin Psychol, Groningen, Netherlands.
   [Bockting, Claudi L. H.] Univ Utrecht, Dept Clin & Hlth Psychol, Utrecht, Netherlands.
   [Pouwer, Francois] Tilburg Univ, Dept Med & Clin Psychol, Ctr Res Psychol Somat Dis CoRPS, NL-5000 LE Tilburg, Netherlands.
   [Ruhe, Henricus G.] Univ Groningen, Univ Med Ctr Groningen, Univ Ctr Psychiat, Program Mood & Anxiety Disorders, NL-9700 AB Groningen, Netherlands.
   [Schene, Aart H.] Radboud Univ Nijmegen Med Ctr, Dept Psychiat, Nijmegen, Netherlands.
   [Schene, Aart H.] Radboud Univ Nijmegen Med Ctr, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam; Arq
   Psychotrauma Expert Group; University of Groningen; Utrecht University;
   Tilburg University; University of Groningen; Radboud University
   Nijmegen; Radboud University Nijmegen
RP Assies, J (corresponding author), Univ Amsterdam, Acad Med Ctr, Dept Psychiat, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
EM j.assies@amc.uva.nl
RI Bockting, Claudi/K-3768-2019; Ruhe, Henricus/K-8764-2012; Schene,
   A.H./H-8085-2014; Mocking, Roel/H-8131-2012
OI Mocking, Roel/0000-0003-3543-3810; Pouwer, Frans/0000-0002-8172-9818;
   Bockting, Claudi L.H./0000-0002-9220-9244
CR Assies J, 2004, PROSTAG LEUKOTR ESS, V70, P349, DOI 10.1016/j.plefa.2003.12.009
   Assies J, 2014, ACTA PSYCHIAT SCAND, V130, P163, DOI 10.1111/acps.12265
   Assies J, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010635
   Baek D, 2013, PROSTAG LEUKOTR ESS, V89, P291, DOI 10.1016/j.plefa.2013.09.008
   Berstad P, 2007, AM J CLIN NUTR, V85, P1598, DOI 10.1093/ajcn/85.6.1598
   Bjelland I, 2003, ARCH GEN PSYCHIAT, V60, P618, DOI 10.1001/archpsyc.60.6.618
   Bockting CLH, 2005, J CONSULT CLIN PSYCH, V73, P647, DOI 10.1037/0022-006X.73.4.647
   Bottiglieri T, 2005, PROG NEURO-PSYCHOPH, V29, P1103, DOI 10.1016/j.pnpbp.2005.06.021
   Carver JD, 2001, BRAIN RES BULL, V56, P79, DOI 10.1016/S0361-9230(01)00551-2
   Crowe FL, 2008, J NUTR, V138, P551, DOI 10.1093/jn/138.3.551
   Davidson MH, 2013, CURR OPIN LIPIDOL, V24, P467, DOI 10.1097/MOL.0000000000000019
   Delmastro-Greenwood M, 2014, ANNU REV PHYSIOL, V76, P79, DOI 10.1146/annurev-physiol-021113-170341
   Devlin AM, 2009, CLIN LIPIDOL, V4, P159, DOI 10.2217/CLP.09.3
   Dodd S, 2008, INT J NEUROPSYCHOPH, V11, P179
   Donders ART, 2006, J CLIN EPIDEMIOL, V59, P1087, DOI 10.1016/j.jclinepi.2006.01.014
   First M.B., 1996, User Guide for the Structured Clinical Interview for DSM-IV Axis I Disorders
   Forman HJ, 2009, MOL ASPECTS MED, V30, P1, DOI 10.1016/j.mam.2008.08.006
   Fuchs D, 2001, CLIN CHEM LAB MED, V39, P691, DOI 10.1515/CCLM.2001.113
   Giustarini D, 2009, CRIT REV CL LAB SCI, V46, P241, DOI 10.3109/10408360903142326
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Graham JW, 2009, ANNU REV PSYCHOL, V60, P549, DOI 10.1146/annurev.psych.58.110405.085530
   Guest J, 2013, LIPIDS HEALTH DIS, V12, DOI 10.1186/1476-511X-12-79
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Harris WS, 2008, ATHEROSCLEROSIS, V197, P12, DOI 10.1016/j.atherosclerosis.2007.11.008
   Hoffman M, 2011, MED HYPOTHESES, V77, P1088, DOI 10.1016/j.mehy.2011.09.009
   Howard D., 2014, PLOS ONE, V9, P1
   Huang T, 2013, BRIT J NUTR, V109, P1688, DOI 10.1017/S000711451200356X
   Huang T, 2012, ASIA PAC J CLIN NUTR, V21, P394
   Huang T, 2012, NUTR J, V11, DOI 10.1186/1475-2891-11-6
   Huang T, 2011, NUTRITION, V27, P863, DOI 10.1016/j.nut.2010.12.011
   Hulbert AJ, 2007, PHYSIOL REV, V87, P1175, DOI 10.1152/physrev.00047.2006
   Humphrey LL, 2008, MAYO CLIN PROC, V83, P1203, DOI 10.4065/83.11.1203
   Kahl KG, 2012, EUR ARCH PSY CLIN N, V262, P313, DOI 10.1007/s00406-011-0277-4
   Kale A, 2010, PSYCHIAT RES, V175, P47, DOI 10.1016/j.psychres.2009.01.013
   Kim JM, 2008, BRIT J PSYCHIAT, V192, P268, DOI 10.1192/bjp.bp.107.039511
   Kume A, 2013, NUTR METAB, V10, DOI 10.1186/1743-7075-10-41
   Li D, 2007, PROSTAG LEUKOTR ESS, V76, P293, DOI 10.1016/j.plefa.2007.02.003
   Li D, 2006, LIPIDS, V41, P85, DOI 10.1007/s11745-006-5074-x
   Lin PY, 2010, BIOL PSYCHIAT, V68, P140, DOI 10.1016/j.biopsych.2010.03.018
   Lok A, 2014, J AFFECT DISORDERS, V166, P115, DOI 10.1016/j.jad.2014.04.048
   Lok A, 2012, PSYCHONEUROENDOCRINO, V37, P892, DOI 10.1016/j.psyneuen.2011.10.005
   Lu Y, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030880
   McGowan, BRAIN RES, V1237, P12
   McIntyre RS, 2009, CURR DIABETES REP, V9, P51, DOI 10.1007/s11892-009-0010-0
   McNamara RK, 2013, PROSTAG LEUKOTR ESS, V88, P33, DOI 10.1016/j.plefa.2012.03.011
   McNamara RK, 2009, PROSTAG LEUKOTR ESS, V81, P223, DOI 10.1016/j.plefa.2009.05.017
   Mocking RJT, 2013, PSYCHONEUROENDOCRINO, V38, P1607, DOI 10.1016/j.psyneuen.2013.01.013
   Mocking RJT, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0049431
   Mocking RJT, 2012, LIPIDS, V47, P541, DOI 10.1007/s11745-012-3665-2
   Morris MS, 2003, PSYCHOTHER PSYCHOSOM, V72, P80, DOI 10.1159/000068692
   Mozaffarian D, 2011, J AM COLL CARDIOL, V58, P2047, DOI 10.1016/j.jacc.2011.06.063
   Murakami K, 2008, NUTRITION, V24, P140, DOI 10.1016/j.nut.2007.10.013
   Nabi H, 2013, PSYCHONEUROENDOCRINO, V38, P2309, DOI 10.1016/j.psyneuen.2013.04.018
   Naviaux RK, 2014, MITOCHONDRION, V16, P7, DOI 10.1016/j.mito.2013.08.006
   Naviaux RK, 2012, J PHARMACOL EXP THER, V342, P608, DOI 10.1124/jpet.112.192120
   Obeid R, 2009, FEBS LETT, V583, P1215, DOI 10.1016/j.febslet.2009.03.038
   Piolot A, 2003, J LAB CLIN MED, V141, P41, DOI 10.1067/mlc.2003.3
   Piomelli D, 2007, NAT REV NEUROSCI, V8, P743, DOI 10.1038/nrn2233
   Pita ML, 2000, THROMB HAEMOSTASIS, V84, P420
   Pooya S, 2010, NUTR METAB CARDIOVAS, V20, P326, DOI 10.1016/j.numecd.2009.04.002
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Schiavone S, 2013, ANTIOXID REDOX SIGN, V18, P1475, DOI 10.1089/ars.2012.4720
   Selley ML, 2007, NEUROBIOL AGING, V28, P1834, DOI 10.1016/j.neurobiolaging.2006.08.003
   Severus WE, 2001, HARVARD REV PSYCHIAT, V9, P280, DOI 10.1080/10673220127910
   Stanger O, 2009, EXPERT REV NEUROTHER, V9, P1393, DOI 10.1586/ERN.09.75
   Terlecky Stanley R, 2012, World J Biol Chem, V3, P93, DOI 10.4331/wjbc.v3.i5.93
   Wang ZM, 2012, NUTR METAB CARDIOVAS, V22, P890, DOI 10.1016/j.numecd.2011.04.011
   Zeman M, 2006, J NUTR BIOCHEM, V17, P379, DOI 10.1016/j.jnutbio.2005.08.007
   Zhao M, 2012, J NUTR, V142, P1791, DOI 10.3945/jn.112.163246
NR 69
TC 13
Z9 13
U1 0
U2 27
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD OCT 30
PY 2015
VL 229
IS 3
BP 992
EP 998
DI 10.1016/j.psychres.2015.06.025
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CS5TN
UT WOS:000362141300047
PM 26260568
OA Green Published
DA 2025-06-11
ER

PT J
AU Bulka, CM
   Persky, VW
   Daviglus, ML
   Durazo-Arvizu, RA
   Argos, M
AF Bulka, Catherine M.
   Persky, Victoria W.
   Daviglus, Martha L.
   Durazo-Arvizu, Ramon A.
   Argos, Maria
TI Multiple metal exposures and metabolic syndrome: A cross-sectional
   analysis of the National Health and Nutrition Examination Survey
   2011-2014
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE Toxic metals; Essential metals; Metabolic syndrome; Epidemiology
ID BLOOD LEAD LEVEL; SERUM SELENIUM; PRESSURE; ASSOCIATION; MERCURY;
   WEIGHT; ZINC; POPULATION; PREVALENCE; ELEMENTS
AB Background: Epidemiologic studies suggest toxic metals are linked with diabetes and cardiovascular disease, while experimental studies indicate nutritionally essential metals are involved in the metabolism of macro nutrients and defense against oxidative stress.
   Objectives: We sought to evaluate how essential and toxic metals are cross-sectionally related to metabolic syndrome, a clustering of cardiometabolic conditions.
   Methods: Using data from the 2011-2014 National Health and Nutrition Examination Survey (n = 1088), we characterized metal concentrations as measured in spot urine (arsenic, cadmium, and inorganic/elemental mercury), whole blood (manganese, lead, methylmercury, and selenium), and serum (copper and zinc) samples. Principal component analysis was performed to derive patterns of exposures. Metabolic syndrome was defined according to the 2009 Joint Scientific Statement as the presence of >= 3 of the following conditions: high blood pressure, high triglycerides, low HDL cholesterol, high fasting glucose, and abdominal obesity.
   Results: After adjustment for potential confounders, prevalence ratios for metabolic syndrome comparing the highest to the lowest quartiles were 1.41 (95% CI: 1.18-1.67) for the arsenic-inorganic/elemental mercury pattern, 0.95 (0.78-1.16) for the methylmercury-manganese pattern, 0.73 (0.57-0.94) for the cadmium-lead pattern, 0.91 (0.76-1.10) for the copper pattern, and 1.36 (1.13-1.63) for the selenium-zinc pattern. The positive associations observed for the arsenic-inorganic/elemental mercury pattern were due to an elevated prevalence of high blood pressure, low HDL cholesterol, and high triglycerides among those with greater exposures. Associations for the selenium-zinc pattern were driven by a positive relationship with high triglycerides. Greater lead-cadmium co-exposures were related to a lower prevalence of dyslipidemia and abdominal obesity.
   Conclusions: These cross-sectional findings suggest both toxic and essential metal exposures may contribute to cardiometabolic health, but need to be confirmed with prospective data.
C1 [Bulka, Catherine M.; Persky, Victoria W.; Argos, Maria] Univ Illinois, Sch Publ Hlth, Div Epidemiol & Biostat, 1603 W Taylor St, Chicago, IL 60612 USA.
   [Daviglus, Martha L.; Durazo-Arvizu, Ramon A.] Univ Illinois, Coll Med, Inst Minor Hlth Res, Chicago, IL USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of Illinois System;
   University of Illinois Chicago; University of Illinois Chicago Hospital
RP Bulka, CM (corresponding author), Univ Illinois, Sch Publ Hlth, Div Epidemiol & Biostat, 1603 W Taylor St, Chicago, IL 60612 USA.
EM cbulka2@uic.edu
FU National Heart, Lung, and Blood Institute (NHLBI) [T32-HL125294]
FX Catherine M. Bulka was supported by the National Heart, Lung, and Blood
   Institute (NHLBI) T32-HL125294.
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   [Anonymous], 2008, Okla Nurse, V53, P25
   [Anonymous], 2012, ENVIRON HEALTH PERSP, DOI DOI 10.1289/ehp.1103988
   [Anonymous], A F T S A D R A TOX
   [Anonymous], A F T S A D R A TOX
   [Anonymous], CURR CONTENTS SOC BE
   [Anonymous], CURR ENV HLTH REP
   [Anonymous], A F T S A D R A TOX
   [Anonymous], A F T S A D R A TOX
   [Anonymous], AM J EPIDEMIOL
   Ashton K, 2009, AM J CLIN NUTR, V89, p2025S, DOI 10.3945/ajcn.2009.27230F
   Bleys J, 2008, AM J CLIN NUTR, V88, P416
   Bleys J, 2007, DIABETES CARE, V30, P829, DOI 10.2337/dc06-1726
   Bridges CC, 2005, TOXICOL APPL PHARM, V204, P274, DOI 10.1016/j.taap.2004.09.007
   Bulka CM, 2017, ENVIRON HEALTH PERSP, V125, DOI 10.1289/EHP1202
   Centers for Disease Control and Prevention (CDC), 2017, 4 CDCP
   Danzeisen R, 2007, BRIT J NUTR, V98, P676, DOI 10.1017/S0007114507798951
   Davis MA, 2017, SCI TOTAL ENVIRON, V586, P1237, DOI 10.1016/j.scitotenv.2017.02.119
   Dickerson AS, 2015, SCI TOTAL ENVIRON, V536, P245, DOI 10.1016/j.scitotenv.2015.07.024
   Eshak E.S., 2017, Clin Nutr
   Feng WQ, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0123520
   Franceschini N, 2017, J HUM HYPERTENS, V31, P225, DOI 10.1038/jhh.2016.67
   Gallagher CM, 2010, ENVIRON HEALTH PERSP, V118, P1676, DOI 10.1289/ehp.1002077
   Gil F, 2015, FOOD CHEM TOXICOL, V80, P287, DOI 10.1016/j.fct.2015.03.025
   Grau-Perez M, 2017, ENVIRON HEALTH PERSP, V125, DOI [10.1289/EHP2566, 10.1289/ehp2566]
   Grundy SM, 2016, TRENDS CARDIOVAS MED, V26, P364, DOI 10.1016/j.tcm.2015.10.004
   Han SG, 1999, ENVIRON HEALTH PERSP, V107, P657, DOI 10.2307/3434458
   Hays SM, 2015, ENVIRON HEALTH PERSP, V123, P293, DOI 10.1289/ehp.1408944
   He K, 2013, DIABETES CARE, V36, P1584, DOI 10.2337/dc12-1842
   Hu H, 2007, ENVIRON HEALTH PERSP, V115, P455, DOI 10.1289/ehp.9783
   Johnson Clifford L, 2014, Vital Health Stat 2, P1
   Jones MR, 2016, AM J EPIDEMIOL, V184, P590, DOI 10.1093/aje/kww097
   Kobal AB, 2003, J TRACE ELEM MED BIO, V17, P261
   KORN EL, 1991, AM J PUBLIC HEALTH, V81, P1166, DOI 10.2105/AJPH.81.9.1166
   Lee BK, 2011, ENVIRON RES, V111, P797, DOI 10.1016/j.envres.2011.05.005
   Mirel Lisa B, 2013, Vital Health Stat 2, P1
   Mortensen ME, 2014, ENVIRON RES, V134, P257, DOI 10.1016/j.envres.2014.07.019
   Muka T, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0129116
   Muller CJ, 2014, INT J EPIDEMIOL, V43, P962, DOI 10.1093/ije/dyu029
   Navas-Acien A, 2008, EPIDEMIOLOGY, V19, P496, DOI 10.1097/EDE.0b013e31816a2400
   Navas-Acien A, 2008, CURR OPIN LIPIDOL, V19, P43, DOI 10.1097/MOL.0b013e3282f2b261
   Obeid O, 2008, BIOL TRACE ELEM RES, V123, P58, DOI 10.1007/s12011-008-8112-0
   Padilla MA, 2010, INT J ENV RES PUB HE, V7, P3332, DOI 10.3390/ijerph7093332
   PENNINGTON J A T, 1990, Journal of Food Composition and Analysis, V3, P166, DOI 10.1016/0889-1575(90)90022-E
   Powell SR, 2000, J NUTR, V130, p1447S, DOI 10.1093/jn/130.5.1447S
   Riedt CS, 2009, J EXPO SCI ENV EPID, V19, P90, DOI 10.1038/jes.2008.5
   Scinicariello F, 2013, TOXICOL APPL PHARM, V273, P516, DOI 10.1016/j.taap.2013.09.022
   Seo JA, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0105990
   Shan ZL, 2016, ENVIRON HEALTH PERSP, V124, P1876, DOI 10.1289/EHP176
   Sigel A, 2009, R SOC CHEM, V5
   Stranges S, 2010, NUTR METAB CARDIOVAS, V20, P754, DOI 10.1016/j.numecd.2010.10.001
   Sun Q, 2009, DIABETES CARE, V32, P629, DOI 10.2337/dc08-1913
   Suzuki T, 2016, J CLIN BIOCHEM NUTR, V58, P48, DOI 10.3164/jcbn.15-71
   Yang CC, 2017, J CLIN LIPIDOL, V11, P234, DOI 10.1016/j.jacl.2016.12.010
   Zhang H, 2010, ENVIRON SCI TECHNOL, V44, P4499, DOI 10.1021/es903565t
NR 56
TC 128
Z9 134
U1 1
U2 64
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
EI 1096-0953
J9 ENVIRON RES
JI Environ. Res.
PD JAN
PY 2019
VL 168
BP 397
EP 405
DI 10.1016/j.envres.2018.10.022
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA HE0ED
UT WOS:000452938700042
PM 30388496
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Zhang, X
   Lerman, LO
AF Zhang, Xin
   Lerman, Lilach O.
TI The metabolic syndrome and chronic kidney disease
SO TRANSLATIONAL RESEARCH
LA English
DT Review
ID OBESITY-RELATED GLOMERULOPATHY; MESANGIAL CELL HYPERTROPHY;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; NAD(P)H
   OXIDASE; INTRAABDOMINAL PRESSURE; INDUCED HYPERTENSION;
   THERAPEUTIC-TARGET; RESPIRATORY-CHAIN
AB The metabolic syndrome (MetS) is a cluster of cardiovascular risk factors including insulin resistance (IR), dyslipidemia, and hypertension, which may also foster development of chronic kidney disease. The mechanisms of MetS-induced kidney disease are not fully understood. The purpose of this review is to summarize recent discoveries regarding the impact of MetS on the kidney, particularly on the renal microvasculature and cellular mitochondria. Fundamental manifestations of MetS include IR and adipose tissue expansion, the latter promoting chronic inflammation and oxidative stress that exacerbate IR. Those in turn can elicit various kidney injurious events through endothelial dysfunction, activation of the renin-angiotensin-aldosterone system, and adipokine imbalance. Inflammation and IR are also major contributors to microvascular remodeling and podocyte injury. Hence, these events may result in hypertension, albuminuria, and parenchymal damage. In addition, dyslipidemia and excessive nutrient availability may impair mitochondrial function and thereby promote progression of kidney cell damage. Elucidation of the link between MetS and kidney injury may help develop preventative measures and possibly novel therapeutic targets to alleviate and avert development of renal manifestations.
C1 [Zhang, Xin; Lerman, Lilach O.] Mayo Clin, Div Nephrol & Hypertens, 200 First St SW, Rochester, MN 55905 USA.
C3 Mayo Clinic
RP Lerman, LO (corresponding author), Mayo Clin, Div Nephrol & Hypertens, 200 First St SW, Rochester, MN 55905 USA.
EM lerman.lilach@mayo.edu
RI Lerman, Lilach/M-4962-2017
FU NIH [DK104273, DK102325, DK73608, DK100081, HL123160]
FX This work was partly supported by NIH Grants DK104273, DK102325,
   DK73608, DK100081, and HL123160.
CR Abadir PM, 2011, P NATL ACAD SCI USA, V108, P14849, DOI 10.1073/pnas.1101507108
   Abd El-Kader MS, 2013, AFR HEALTH SCI, V13, P682, DOI 10.4314/ahs.v13i3.23
   Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Al-Shanti N, 2012, J CELL BIOCHEM, V113, P923, DOI 10.1002/jcb.23420
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alexander MP, 2009, AM J KIDNEY DIS, V53, P751, DOI 10.1053/j.ajkd.2009.01.255
   Armitage JA, 2012, HYPERTENSION, V60, P163, DOI 10.1161/HYPERTENSIONAHA.111.190413
   Axelsson J, 2006, KIDNEY INT, V69, P596, DOI 10.1038/sj.ki.5000089
   Bahceci M, 2007, J ENDOCRINOL INVEST, V30, P210, DOI 10.1007/BF03347427
   Baldwin W, 2011, DIABETES, V60, P1258, DOI 10.2337/db10-0916
   Block K, 2008, J BIOL CHEM, V283, P24061, DOI 10.1074/jbc.M803964200
   Block K, 2009, P NATL ACAD SCI USA, V106, P14385, DOI 10.1073/pnas.0906805106
   Bondi CD, 2010, J AM SOC NEPHROL, V21, P93, DOI 10.1681/ASN.2009020146
   Bonnard C, 2008, J CLIN INVEST, V118, P789, DOI 10.1172/JCI32601
   BRAND MD, 1987, BIOL REV, V62, P141, DOI 10.1111/j.1469-185X.1987.tb01265.x
   Brands MW, 2012, AM J PHYSIOL-REG I, V303, pR1101, DOI 10.1152/ajpregu.00390.2012
   Briones AM, 2012, HYPERTENSION, V59, P1069, DOI 10.1161/HYPERTENSIONAHA.111.190223
   BROWN GC, 1992, BIOCHEM J, V284, P1
   Buglioni A, 2015, HYPERTENSION, V65, P45, DOI 10.1161/HYPERTENSIONAHA.114.03936
   Burlacu A, 2015, J AM HEART ASSOC, V4, DOI 10.1161/JAHA.115.002379
   Buscemi S, 2009, DIABETES RES CLIN PR, V86, P177, DOI 10.1016/j.diabres.2009.09.015
   Busch M, 2010, EUR J CLIN INVEST, V40, P742, DOI 10.1111/j.1365-2362.2010.02317.x
   BUTLEN D, 1988, PFLUG ARCH EUR J PHY, V412, P604, DOI 10.1007/BF00583761
   Carlyle M, 2002, HYPERTENSION, V39, P496, DOI 10.1161/hy0202.104398
   Chade AR, 2016, AM J NEPHROL, V44, P354, DOI 10.1159/000452365
   Chen HM, 2006, AM J KIDNEY DIS, V48, P772, DOI 10.1053/j.ajkd.2006.07.025
   Chen J, 2003, J AM SOC NEPHROL, V14, P469, DOI 10.1097/01.ASN.0000046029.53933.09
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Chen KH, 2011, CHEM-BIOL INTERACT, V190, P45, DOI 10.1016/j.cbi.2011.01.033
   Choi HK, 2007, AM J MED, V120, P442, DOI 10.1016/j.amjmed.2006.06.040
   Cobb WS, 2005, J SURG RES, V129, P231, DOI 10.1016/j.jss.2005.06.015
   COHEN AJ, 1989, AM J PHYSIOL, V257, pF580, DOI 10.1152/ajprenal.1989.257.4.F580
   Costa Carla, 2007, Angiogenesis, V10, P149, DOI 10.1007/s10456-007-9074-0
   Cushman William C, 2002, J Clin Hypertens (Greenwich), V4, P393
   D'Agati VD, 2016, NAT REV NEPHROL, V12, P453, DOI 10.1038/nrneph.2016.75
   Danziger J, 2008, NEPHROL DIAL TRANSPL, V23, P2733, DOI 10.1093/ndt/gfn260
   Davies MR, 2005, J AM SOC NEPHROL, V16, P917, DOI 10.1681/ASN.2004100835
   De Benedetti F, 2001, ENDOCRINOLOGY, V142, P4818, DOI 10.1210/en.142.11.4818
   De Cosmo S, 2013, NEPHROL DIAL TRANSPL, V28, P29, DOI 10.1093/ndt/gfs290
   de Vries APJ, 2004, AM J TRANSPLANT, V4, P1675, DOI 10.1111/j.1600-6143.2004.00558.x
   DeFina LF, 2012, J INVEST MED, V60, P1164, DOI 10.2310/JIM.0b013e318275656a
   Dikalov SI, 2013, ANTIOXID REDOX SIGN, V19, P1085, DOI 10.1089/ars.2012.4604
   Dominguez J, 2007, AM J PHYSIOL-RENAL, V293, pF670, DOI 10.1152/ajprenal.00021.2007
   Duchen MR, 2010, ESSAYS BIOCHEM, V47, P115, DOI [10.1042/bse0470115, 10.1042/BSE0470115]
   Dugan LL, 2013, J CLIN INVEST, V123, P4888, DOI 10.1172/JCI66218
   Eid AA, 2013, MOL CELL BIOL, V33, P3439, DOI 10.1128/MCB.00217-13
   Eid AA, 2013, DIABETES, V62, P2935, DOI 10.2337/db12-1504
   Eid AA, 2010, J BIOL CHEM, V285, P37503, DOI 10.1074/jbc.M110.136796
   Eid AA, 2009, DIABETES, V58, P1201, DOI 10.2337/db08-1536
   Eirin A, 2016, HDB EXP PHARM
   Eirin A, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.115.003118
   Eirin A, 2015, HYPERTENSION, V65, P264, DOI 10.1161/HYPERTENSIONAHA.114.04598
   Engeli S, 2005, HYPERTENSION, V45, P356, DOI 10.1161/01.HYP.0000154361.47683.d3
   Forsythe LKS, 2008, NUTR RES REV, V21, P117, DOI 10.1017/S0954422408138732
   Fortuño A, 2006, DIABETES, V55, P209, DOI 10.2337/diabetes.55.1.209
   FRIEDMAN JE, 1991, AM J PHYSIOL, V261, pE87, DOI 10.1152/ajpendo.1991.261.1.E87
   Fujita T, 2008, J MOL MED, V86, P729, DOI 10.1007/s00109-008-0343-1
   Fuku N, 2007, AM J HUM GENET, V80, P407, DOI 10.1086/512202
   Fukuda A, 2012, J AM SOC NEPHROL, V23, P1351, DOI 10.1681/ASN.2012030271
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Geiszt M, 2000, P NATL ACAD SCI USA, V97, P8010, DOI 10.1073/pnas.130135897
   Gödel M, 2011, J CLIN INVEST, V121, P2197, DOI 10.1172/JCI44774
   Goldfine AB, 2010, ANN INTERN MED, V152, P346, DOI 10.7326/0003-4819-152-6-201003160-00004
   Goldfine AB, 2008, CTS-CLIN TRANSL SCI, V1, P36, DOI 10.1111/j.1752-8062.2008.00026.x
   Granata S, 2015, NUTR METAB, V12, DOI 10.1186/s12986-015-0044-z
   Groop PH, 2005, NAT CLIN PRACT ENDOC, V1, P100, DOI 10.1038/ncpendmet0046
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Habeeballah H, 2016, EXP PHYSIOL, V101, P791, DOI 10.1113/EP085723
   Hale LJ, 2013, AM J PHYSIOL-RENAL, V305, pF182, DOI 10.1152/ajprenal.00548.2012
   HALL JE, 1993, HYPERTENSION, V22, P292, DOI 10.1161/01.HYP.22.3.292
   Hall JE, 2015, CIRC RES, V116, P991, DOI 10.1161/CIRCRESAHA.116.305697
   Hall ME, 2014, INT J NEPHROL RENOV, V7, P75, DOI 10.2147/IJNRD.S39739
   Hayashi K, 1997, KIDNEY INT, V51, P1507, DOI 10.1038/ki.1997.207
   Hoehn KL, 2009, P NATL ACAD SCI USA, V106, P17787, DOI 10.1073/pnas.0902380106
   Hoehner CM, 2002, J AM SOC NEPHROL, V13, DOI 10.1097/01.ASN.0000015762.92814.85
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Huang PL, 2005, CIRC RES, V96, P1129, DOI 10.1161/01.RES.0000170705.56583.45
   Jheng HF, 2015, DIS MODEL MECH, V8, P1311, DOI 10.1242/dmm.019398
   Kambham N, 2001, KIDNEY INT, V59, P1498, DOI 10.1046/j.1523-1755.2001.0590041498.x
   Khosla UM, 2005, KIDNEY INT, V67, P1739, DOI 10.1111/j.1523-1755.2005.00273.x
   Kim EY, 2012, AM J PHYSIOL-RENAL, V302, pF298, DOI 10.1152/ajprenal.00423.2011
   Kim EY, 2011, J CELL PHYSIOL, V226, P2307, DOI 10.1002/jcp.22567
   Kim YW, 2014, BLOOD, V123, P625, DOI 10.1182/blood-2013-09-512749
   Kosari S, 2012, J NEUROENDOCRINOL, V24, P1432, DOI 10.1111/j.1365-2826.2012.02352.x
   Koziel R, 2013, BIOCHEM J, V452, P231, DOI 10.1042/BJ20121778
   Kriz W, 1998, NEPHROL DIAL TRANSPL, V13, P2781, DOI 10.1093/ndt/13.11.2781
   KRIZ W, 1995, J AM SOC NEPHROL, V5, P1731
   Kümpers P, 2007, AM J PHYSIOL-RENAL, V293, pF1355, DOI 10.1152/ajprenal.00003.2007
   Kurella M, 2005, J AM SOC NEPHROL, V16, P2134, DOI 10.1681/ASN.2005010106
   Kusminski CM, 2005, CLIN SCI, V109, P243, DOI 10.1042/CS20050078
   Lee HK, 1998, DIABETES RES CLIN PR, V42, P161, DOI 10.1016/S0168-8227(98)00110-7
   Lee MPS, 2005, INT J OBESITY, V29, P1395, DOI 10.1038/sj.ijo.0803031
   Lerman LO, 2011, REV ESP CARDIOL, V64, P358, DOI 10.1016/j.recesp.2011.01.005
   Li L, 2014, BMC NEPHROL, V15, DOI 10.1186/1471-2369-15-122
   Li SZ, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0159230
   Li ZL, 2012, ARTERIOSCL THROM VAS, V32, P1132, DOI 10.1161/ATVBAHA.111.244061
   Li ZL, 2011, AM J PHYSIOL-RENAL, V301, pF1078, DOI 10.1152/ajprenal.00333.2011
   Locatelli F, 2006, J AM SOC NEPHROL, V17, pS81, DOI 10.1681/ASN.2005121332
   Lovisa S, 2016, TRENDS ENDOCRIN MET, V27, P681, DOI 10.1016/j.tem.2016.06.004
   Luk AOY, 2008, DIABETES CARE, V31, P2357, DOI 10.2337/dc08-0971
   Ma ST, 2016, J UROLOGY, V195, P1152, DOI 10.1016/j.juro.2015.08.105
   Mazzali M, 2001, HYPERTENSION, V38, P1101, DOI 10.1161/hy1101.092839
   Menzaghi C, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038414
   Miller AW, 2002, HYPERTENSION, V40, P78, DOI 10.1161/01.HYP.0000022806.87281.62
   Mima A, 2011, KIDNEY INT, V79, P883, DOI 10.1038/ki.2010.526
   Mitsuishi M, 2009, DIABETES, V58, P710, DOI 10.2337/db08-0949
   Miyamoto S, 2013, NEPHROL DIAL TRANSPL, V28, P15, DOI 10.1093/ndt/gft261
   MOSTBECK GH, 1991, J ULTRAS MED, V10, P189, DOI 10.7863/jum.1991.10.4.189
   Nakagawa T, 2003, CURR OPIN NEPHROL HY, V12, P233, DOI 10.1097/00041552-200305000-00003
   Nakagawa T, 2006, AM J PHYSIOL-RENAL, V290, pF625, DOI 10.1152/ajprenal.00140.2005
   NAKAMURA R, 1983, J CLIN INVEST, V72, P388, DOI 10.1172/JCI110979
   Namikoshi T, 2008, HYPERTENS RES, V31, P745, DOI 10.1291/hypres.31.745
   NESTLER JE, 1990, DIABETES, V39, P1212, DOI 10.2337/diabetes.39.10.1212
   Nunnari J, 2012, CELL, V148, P1145, DOI 10.1016/j.cell.2012.02.035
   Ohashi K, 2006, HYPERTENSION, V47, P1108, DOI 10.1161/01.HYP.0000222368.43759.a1
   Pandey D, 2014, CIRC RES, V115, P450, DOI 10.1161/CIRCRESAHA.115.304262
   Papadimitriou A, 2014, CELL PHYSIOL BIOCHEM, V34, P1260, DOI 10.1159/000366336
   Porrini E, 2006, AM J KIDNEY DIS, V48, P134, DOI 10.1053/j.ajkd.2006.04.078
   Rüster C, 2013, NEPHROL DIAL TRANSPL, V28, P8, DOI 10.1093/ndt/gft191
   Rutkowski JM, 2013, J AM SOC NEPHROL, V24, P268, DOI 10.1681/ASN.2012040414
   Sanchez-Lozada LG, 2007, AM J PHYSIOL-RENAL, V292, pF423, DOI 10.1152/ajprenal.00124.2006
   Sarafidis PA, 2007, J CLIN ENDOCR METAB, V92, P379, DOI 10.1210/jc.2006-1819
   Sharma K, 2008, J CLIN INVEST, V118, P1645, DOI 10.1172/JCI32691
   Sharma K, 2014, KIDNEY INT SUPPL, V4, P113, DOI 10.1038/kisup.2014.21
   Sharma K, 2013, J AM SOC NEPHROL, V24, P1901, DOI 10.1681/ASN.2013020126
   Sharma K, 2009, KIDNEY INT, V76, P145, DOI 10.1038/ki.2009.137
   Stanley TL, 2011, J CLIN ENDOCR METAB, V96, pE146, DOI 10.1210/jc.2010-1170
   Sugerman H, 1997, J INTERN MED, V241, P71, DOI 10.1046/j.1365-2796.1997.89104000.x
   Sur Genel, 2014, Maedica (Bucur), V9, P15
   Takabe W, 2010, ARTERIOSCL THROM VAS, V30, P436, DOI 10.1161/ATVBAHA.109.202135
   ter Maaten JC, 2000, EUR J CLIN INVEST, V30, P1090, DOI 10.1046/j.1365-2362.2000.00749.x
   Tobar A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0075547
   Vicent D, 2003, J CLIN INVEST, V111, P1373, DOI 10.1172/JCI200315211
   Wallace DC, 2010, ANNU REV PATHOL-MECH, V5, P297, DOI 10.1146/annurev.pathol.4.110807.092314
   Wang SN, 2001, KIDNEY INT, V60, P96, DOI 10.1046/j.1523-1755.2001.00776.x
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Whaley-Connell A, 2008, HYPERTENSION, V51, P474, DOI 10.1161/HYPERTENSIONAHA.107.102467
   Wiggins JE, 2005, J AM SOC NEPHROL, V16, P2953, DOI 10.1681/ASN.2005050488
   Wingler M, 2001, FREE RADICAL BIO MED, V31, P1456, DOI 10.1016/S0891-5849(01)00727-4
   Yoo TW, 2005, CIRC J, V69, P928, DOI 10.1253/circj.69.928
   Yvan-Charvet L, 2011, KIDNEY INT, V79, P162, DOI 10.1038/ki.2010.391
   Zhang X, 2013, AM J PHYSIOL-RENAL, V305, pF265, DOI 10.1152/ajprenal.00043.2013
   Zhou RB, 2010, NAT IMMUNOL, V11, P136, DOI 10.1038/ni.1831
   Zhu CH, 2011, AM J PATHOL, V178, P2020, DOI 10.1016/j.ajpath.2011.01.029
NR 144
TC 102
Z9 108
U1 0
U2 22
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1931-5244
EI 1878-1810
J9 TRANSL RES
JI Transl. Res.
PD MAY
PY 2017
VL 183
BP 14
EP 25
DI 10.1016/j.trsl.2016.12.004
PG 12
WC Medical Laboratory Technology; Medicine, General & Internal; Medicine,
   Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology; General & Internal Medicine; Research &
   Experimental Medicine
GA EU3TL
UT WOS:000400953800002
PM 28025032
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Iplikci, B
   Can, B
   Iplikci, A
   Sargin, M
AF Iplikci, Busra
   Can, Bulent
   Iplikci, Ayberk
   Sargin, Mehmet
TI How Does Metabolic Syndrome Affect Sexual Function in Obese Women?
SO KONURALP TIP DERGISI
LA English
DT Article
DE Bioelectrical Impedance; Female Sexual Dysfunction; Metabolic Syndrome;
   Obesity
ID INDEX FSFI; DYSFUNCTION; PREVALENCE
AB Objective: Metabolic syndrome (MetS) is significant public health concern with a rising prevalence. MetS leads to diseases such as diabetes mellitus, arterial hypertension (HTN) and atherosclerotic heart disease, as well as female sexual dysfunction (FSD). However, the relationship of MetS to female sexual function in obese woman is unclear. In our study, obese women and obese women with MetS were compared. We aimed to determine whether there was a difference between the two groups in terms of FSD. Method: The study included 114 patients, aged 21-51, who visited the obesity outpatient clinic of our center from January to April 2022. Patients who met the study criteria answered the sociodemographic data questionnaire, Female Sexual Function Index (FSFI), and the Beck Depression Inventory (BDI). Anthropometric measurements and blood pressure assessments were conducted during the visit, and blood tests were recorded. Results: Seventy-three (64%) patients were only obese, and 41 (36%) had a diagnosis of MetS with obesity. There was no significant difference between the two groups in terms of demographic data, clinical features, BDI scores, and FSFI total score. Lubrication, one of the FSFI subparameters, was found to be low in the group with MetS (p=0.028), while there was no difference in other subparameters. Conclusion: In this study, we showed that lubrication as a sign of arousal problem is affected by MetS. Patients with risk factors for FSD such as MetS, obesity, HTN, diabetes mellitus should not be ignored. Thus, it will be possible to prevent the effects of FSD on general health.
C1 [Iplikci, Busra; Sargin, Mehmet] Istanbul Medeniyet Univ, Fac Med, Dept Family Med, Istanbul, Turkiye.
   [Can, Bulent] Istanbul Medeniyet Univ, Fac Med, Dept Endocrinol, Istanbul, Turkiye.
   [Iplikci, Ayberk] Istanbul Medeniyet Univ, Fac Med, Dept Urol, Istanbul, Turkiye.
C3 Istanbul Medeniyet University; Istanbul Medeniyet University; Istanbul
   Medeniyet University
RP Iplikci, A (corresponding author), Istanbul Medeniyet Univ, Fac Med, Dept Urol, Istanbul, Turkiye.
EM ayberkiplikci@gmail.com
RI Iplikci, Ayberk/GPX-8439-2022; Can, Bülent/JCE-0561-2023; SARGIN,
   Mehmet/GLT-5402-2022
OI Iplikci, Ayberk/0000-0002-5822-7799
CR Adolfsson B, 2004, OBES RES, V12, P1702, DOI 10.1038/oby.2004.211
   Althof SE, 2005, J SEX MED, V2, P793, DOI 10.1111/j.1743-6109.2005.00145.x
   [Anonymous], 2016, Obesity and overweight fact sheet
   Bajos N, 2010, BRIT MED J, V340, DOI 10.1136/bmj.c2573
   Berman JR, 2001, UROL CLIN N AM, V28, P405, DOI 10.1016/S0094-0143(05)70148-8
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Davis SR, 2004, J SEX MED, V1, P82, DOI 10.1111/j.1743-6109.2004.10112.x
   De Franciscis P, 2013, CLIN EXP OBSTET GYN, V40, P58
   Doumas M, 2012, J HYPERTENS, V30, P1263, DOI 10.1097/HJH.0b013e328352664f
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Esposito K, 2005, INT J IMPOT RES, V17, P224, DOI 10.1038/sj.ijir.3901310
   Garcia S, 2008, J SEX MED, V5, P1208, DOI 10.1111/j.1743-6109.2007.00718.x
   Giuliano F, 2013, PROG UROL, V23, P629, DOI 10.1016/j.purol.2013.01.010
   Graziottin A, 2007, J SEX MED, V4, P211, DOI 10.1111/j.1743-6109.2007.00447.x
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Hisli N., 1989, Turk Psikoloji Dergisi, V23, P3, DOI DOI 10.1023/A:1025573315492
   Kadioglu P, 2010, BJU INT, V106, P1357, DOI 10.1111/j.1464-410X.2010.09348.x
   Kirchengast S, 1996, MATURITAS, V23, P63, DOI 10.1016/0378-5122(95)00954-X
   Laumann EO, 1999, JAMA-J AM MED ASSOC, V281, P537, DOI 10.1001/jama.281.6.537
   Oksuz E, 2006, J UROLOGY, V175, P654, DOI 10.1016/S0022-5347(05)00149-7
   OKSUZ E., 2005, Sendrom, V17, P54
   Rosen R, 2000, J SEX MARITAL THER, V26, P191, DOI 10.1080/009262300278597
   Traish AM, 2010, J SEX MED, V7, P2925, DOI 10.1111/j.1743-6109.2010.01903.x
   Turkiye Endokrinoloji ve Metabolizma Dernegi, Obezite tani ve tedavi kilavuzu 2019, V8
   Wiegel M, 2005, J SEX MARITAL THER, V31, P1, DOI 10.1080/00926230590475206
   Zimmet P, 2005, J ATHEROSCLER THROMB, V12, P295, DOI 10.5551/jat.12.295
NR 26
TC 0
Z9 0
U1 0
U2 0
PU DUZCE UNIV, FAC MEDICINE
PI DUZCE
PA KONURALP CAMPUS YORUK MAH CENTER, DUZCE, 81620, Turkiye
SN 1309-3878
J9 KONURALP TIP DERG
JI Konuralp Tip Derg.
PY 2024
VL 16
IS 3
BP 311
EP 316
DI 10.18521/ktd.1524374
PG 6
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA N3C8Y
UT WOS:001363168300002
OA gold
DA 2025-06-11
ER

PT J
AU Fikry, H
   Saleh, LA
   Sadek, DR
   Alkhalek, HAA
AF Fikry, Heba
   Saleh, Lobna A.
   Sadek, Doaa Ramadan
   Alkhalek, Hadwa Ali Abd
TI The possible protective effect of luteolin on cardiovascular and hepatic
   changes in metabolic syndrome rat model
SO CELL AND TISSUE RESEARCH
LA English
DT Article
DE Metabolic syndrome; Fructose; Liver; Heart; Rats; Histological
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; HIGH-FRUCTOSE; DIETARY
   FRUCTOSE; OXIDATIVE STRESS; ADIPOSE-TISSUE; STELLATE CELLS; TNF-ALPHA;
   KAPPA-B; FIBROSIS
AB The metabolic syndrome, or MetS, is currently a global health concern. The anti-inflammatory, anti-proliferative, and antioxidant properties of luteolin are some of its advantageous pharmacological characteristics. This research was designed to establish a MetS rat model and investigate the possible protective effect of luteolin on cardiovascular, hepatic, and metabolic changes in diet-induced metabolic syndrome in rats. Forty adult male albino rats were split into four groups: a negative control group, a group treated with luteolin, a group induced MetS (fed 20% fructose), and a group treated with luteolin (fed 20% fructose and given luteolin). Following the experiment after 8 weeks, biochemical, histological (light and electron), and immunohistochemistry analyses were performed on liver and heart tissues. Serum levels of cTnI, CK-MB, and LDH were significantly elevated in response to the cardiovascular effect of MetS. Furthermore, compared to the negative control group, the MetS group showed a marked increase in lipid peroxidation in the cardiac and hepatic tissues, as evidenced by elevated levels of MDA and a decline in the antioxidant defense system, as demonstrated by lower activities of GSH and SOD. The fatty liver-induced group exhibited histological alterations, including disrupted hepatic architecture, dilated and congested central veins, blood sinusoids, and portal veins. In addition to nuclear structural alterations, most hepatocytes displayed varying degrees of cytoplasmic vacuolation, mitochondrial alterations, and endoplasmic reticulum dilatation. These alterations were linked to inflammatory cellular infiltrations, collagen fiber deposition, active hepatic stellate cells, and scattered hypertrophied Kupffer cells, as demonstrated by electron microscopy and validated by immunohistochemical analysis. It is interesting to note that eosinophils were seen between the liver cells and in dilated blood sinusoids. Moreover, the biochemical (hepatic and cardiac) and histological (liver) changes were significantly less severe in luteolin-treated rat on a high-fructose diet. These results suggested that luteolin protects against a type of metabolic syndrome that is produced experimentally.
C1 [Fikry, Heba; Sadek, Doaa Ramadan; Alkhalek, Hadwa Ali Abd] Ain Shams Univ, Fac Med, Dept Histol & Cell Biol, Khalifa El Maamon St,Abbasiya Sq, Cairo, Egypt.
   [Saleh, Lobna A.] Ain Shams Univ, Fac Med, Dept Clin Pharmacol, Khalifa El Maamon St,Abbasiya Sq, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Ain Shams University; Egyptian Knowledge
   Bank (EKB); Ain Shams University
RP Fikry, H (corresponding author), Ain Shams Univ, Fac Med, Dept Histol & Cell Biol, Khalifa El Maamon St,Abbasiya Sq, Cairo, Egypt.
EM hebafikry@med.asu.edu.eg; Lobnasaleh_80@yahoo.com;
   d.sadek@med.asu.edu.eg; Hadwa.ali@gmail.com
RI fikry, heba/GRN-8415-2022
OI fikry, heba/0000-0002-0046-9875
CR Abdel-Razek HA., 2017, MENOUFIA MED J, V30, P286, DOI [10.4103/1110-2098.211506, DOI 10.4103/1110-2098.211506]
   Abdulla MH, 2011, EUR J NUTR, V50, P251, DOI 10.1007/s00394-010-0133-8
   Abo-Youssef AM, 2015, INDIAN J PHARMACOL, V47, P620, DOI 10.4103/0253-7613.169577
   Abu-Elsaad N, 2019, PHARMACOL REP, V71, P688, DOI 10.1016/j.pharep.2019.03.009
   Abu-Elsaad N, 2018, INFLAMMATION, V41, P221, DOI 10.1007/s10753-017-0680-8
   Ahmed ESA, 2022, INT J IMMUNOPATH PH, V36, DOI 10.1177/03946320221137435
   Akila P, 2017, BIOMED PHARMACOTHER, V85, P582, DOI 10.1016/j.biopha.2016.11.067
   Al-Hail N, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00659
   Al-Megrin WA, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9010010
   Al-Rasheed NM, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/1092015
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Albrahim T, 2021, BIOMED PHARMACOTHER, V141, DOI 10.1016/j.biopha.2021.111831
   Ali ES, 2019, TRENDS ENDOCRIN MET, V30, P270, DOI 10.1016/j.tem.2019.02.005
   Allameh A, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12091653
   Andrade N, 2020, EUR J NUTR, V59, P151, DOI 10.1007/s00394-019-01895-9
   Aoun R, 2022, DIABETOL METAB SYNDR, V14, DOI 10.1186/s13098-022-00800-5
   Arruda HS, 2020, J FUNCT FOODS, V75, DOI 10.1016/j.jff.2020.104203
   Ashokkumar P, 2008, BIOMED PHARMACOTHER, V62, P590, DOI 10.1016/j.biopha.2008.06.031
   Aydin S, 2014, NUTRITION, V30, P1, DOI 10.1016/j.nut.2013.05.013
   Aziz N, 2018, J ETHNOPHARMACOL, V225, P342, DOI 10.1016/j.jep.2018.05.019
   Badmus OO, 2022, CLIN SCI, V136, P1347, DOI 10.1042/CS20220572
   Batchuluun B, 2022, NAT REV DRUG DISCOV, V21, P283, DOI 10.1038/s41573-021-00367-2
   Batudeligen, 2023, DRUG DES DEV THER, V17, P1819, DOI 10.2147/DDDT.S402864
   Bilginoglu A, 2019, J CHIN MED ASSOC, V82, P452, DOI 10.1097/JCMA.0000000000000103
   Bratoeva K, 2018, METAB SYNDR RELAT D, V16, P350, DOI 10.1089/met.2017.0162
   Caliceti C, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040395
   Caporali S, 2022, NUTRIENTS, V14, DOI 10.3390/nu14061155
   Catrysse L, 2017, TRENDS CELL BIOL, V27, P417, DOI 10.1016/j.tcb.2017.01.006
   Chan AML, 2021, NUTRIENTS, V13, DOI 10.3390/nu13082497
   Chen LY, 2023, J FUNCT FOODS, V102, DOI 10.1016/j.jff.2023.105461
   Chung SW, 2013, KOREAN J FAM MED, V34, P420, DOI 10.4082/kjfm.2013.34.6.420
   Cui HY, 2022, CHEMOSPHERE, V308, DOI 10.1016/j.chemosphere.2022.136543
   Dar AA, 2021, HUM EXP TOXICOL, V40, P1194, DOI 10.1177/0960327121991905
   de Oliveira MC, 2023, METABOLISM, V146, DOI 10.1016/j.metabol.2023.155613
   Denisenko YK, 2020, J OBES, V2020, DOI 10.1155/2020/5762395
   Di Luccia B, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0134893
   Donaldson J, 2019, J SCI FOOD AGR, V99, P6954, DOI 10.1002/jsfa.9984
   Douard Veronique, 2008, Am J Physiol Endocrinol Metab, V295, pE227, DOI 10.1152/ajpendo.90245.2008
   Duarte N, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/984578
   El-Bassossy HM, 2013, PHYTOTHER RES, V27, P1678, DOI 10.1002/ptr.4917
   El-Mehi AE, 2020, FOLIA MORPHOL, V79, P690, DOI 10.5603/FM.a2019.0139
   El-mehi AE., 2023, EGYPT J HISTOL, V46, P796
   Elwan WM., 2022, EGYPT J HISTOL, V45, P1189
   Engin A, 2017, ADV EXP MED BIOL, V960, P1, DOI 10.1007/978-3-319-48382-5_1
   Engstler AJ, 2016, GUT, V65, P1564, DOI 10.1136/gutjnl-2014-308379
   Fakhruddin S, 2018, EXP PHYSIOL, V103, P236, DOI 10.1113/EP086604
   Feng M, 2018, INT J BIOL SCI, V14, P1033, DOI 10.7150/ijbs.25589
   Frank M, 2012, ENDOCR PRACT, V18, P387, DOI 10.4158/EP11316.OR
   Furukawa S., 2004, Journal of Clinical Investigation, V114, P1752, DOI 10.1172/JCI21625
   Gadd VL, 2014, HEPATOLOGY, V59, P1393, DOI 10.1002/hep.26937
   Gao HL, 2023, NUTRIENTS, V15, DOI 10.3390/nu15030502
   Gentile D, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01094
   Gentile D, 2018, NUTR RES REV, V31, P239, DOI 10.1017/S0954422418000082
   Gibson-Corley KN, 2013, VET PATHOL, V50, P1007, DOI 10.1177/0300985813485099
   Giussani M, 2022, FRONT MED-LAUSANNE, V9, DOI 10.3389/fmed.2022.792949
   Hassan NF., 2018, J MICROSCOPY ULTRAST, V6, P44, DOI [10.4103/JMAU.JMAU518, DOI 10.4103/JMAU.JMAU_5_18, 10.4103/jmau.jmau5_18, DOI 10.4103/JMAU.JMAU518]
   Hattori H, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9050541
   Diniz MDHS, 2020, CAD SAUDE PUBLICA, V36, DOI [10.1590/0102-311x00072120, 10.1590/0102-311X00072120]
   Huang HB, 2018, IRAN J BASIC MED SCI, V21, P267, DOI 10.22038/ijbms.2018.26110.6415
   Huang Q, 2015, J FUNCT FOODS, V19, P487, DOI 10.1016/j.jff.2015.09.020
   Guzmán-Gerónimo RI, 2017, J MED FOOD, V20, P110, DOI [10.1089/jmf.2016.0087, 10.1089/jmf.2016.3851]
   Jacob A, 2021, HELIYON, V7, DOI 10.1016/j.heliyon.2021.e07845
   Jan R, 2019, ADV PHARM BULL, V9, P205, DOI 10.15171/apb.2019.024
   Jang C, 2018, CELL METAB, V27, P351, DOI 10.1016/j.cmet.2017.12.016
   Janssen JAMJL, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23158178
   Jensen T, 2018, J HEPATOL, V68, P1063, DOI 10.1016/j.jhep.2018.01.019
   Jia ZQ, 2015, J NUTR BIOCHEM, V26, P293, DOI 10.1016/j.jnutbio.2014.11.008
   Jiang YH, 2022, PPAR RES, V2022, DOI 10.1155/2022/8161946
   Jin X, 2023, ACTA PHARM SIN B, V13, P2403, DOI 10.1016/j.apsb.2023.01.012
   Jones M.L., 2008, THEORY PRACTICE HIST, V6, P135, DOI DOI 10.1016/B978-0-443-10279-0.50017-8
   Kelany ME, 2017, CAN J PHYSIOL PHARM, V95, P140, DOI 10.1139/cjpp-2016-0152
   Khadrawy SM, 2023, FOODS, V12, DOI 10.3390/foods12061223
   Khayyat L., 2012, The Journal of American Science, V8, P688
   Khomich O, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9010024
   Kim JY, 2017, INT J MOL MED, V39, P1188, DOI 10.3892/ijmm.2017.2922
   Kohli R, 2010, HEPATOLOGY, V52, P934, DOI 10.1002/hep.23797
   Kolodziejczyk AA, 2019, EMBO MOL MED, V11, DOI 10.15252/emmm.201809302
   Kubacka M, 2019, NUTR METAB CARDIOVAS, V29, P751, DOI 10.1016/j.numecd.2019.04.003
   Kucera O, 2014, WORLD J GASTROENTERO, V20, P8364, DOI 10.3748/wjg.v20.i26.8364
   Kwitek AE, 2019, METHODS MOL BIOL, V2018, P269, DOI 10.1007/978-1-4939-9581-3_13
   Kwon EY, 2018, NUTRIENTS, V10, DOI 10.3390/nu10080979
   Kwon EY, 2015, DIABETES, V64, P1658, DOI 10.2337/db14-0631
   Lee EH, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-28371-4
   Lee Jai Sun, 2015, ScientificWorldJournal, V2015, P306326, DOI 10.1155/2015/306326
   Lelis DD, 2020, LIFE SCI, V259, DOI 10.1016/j.lfs.2020.118235
   Li J, 2015, LIVER INT, V35, P1222, DOI 10.1111/liv.12638
   Lim JS, 2010, NAT REV GASTRO HEPAT, V7, P251, DOI 10.1038/nrgastro.2010.41
   Lodhi S, 2020, J TRADIT COMPL MED, V10, P60, DOI 10.1016/j.jtcme.2019.02.004
   Lotowska JM, 2014, WORLD J GASTROENTERO, V20, P4335, DOI 10.3748/wjg.v20.i15.4335
   Lubawy Michalina, 2023, Int J Environ Res Public Health, V20, DOI 10.3390/ijerph20043596
   Mamikutty N, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/895961
   Mamikutty N, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/263897
   Mansy SS, 2010, ULTRASTRUCT PATHOL, V34, P62, DOI 10.3109/01913120903506645
   Merino B, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010094
   Mert H, 2022, ARCH PHYSIOL BIOCHEM, V128, P1539, DOI 10.1080/13813455.2020.1781900
   Miao LC, 2023, FOOD SCI HUM WELL, V12, P1991, DOI 10.1016/j.fshw.2023.03.021
   Muriel P, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22136969
   Nafady Allam Mohamed, 2017, J Microsc Ultrastruct, V5, P21, DOI 10.1016/j.jmau.2016.04.003
   Nergiz-Unal R, 2020, NUTRITION, V79-80, DOI 10.1016/j.nut.2020.110954
   Neuman MG, 2019, THER DRUG MONIT, V41, P227, DOI 10.1097/FTD.0000000000000610
   Nguyen-Lefebvre AT., 2015, J Enzymol Metabol, V1, P101
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Odum EP, 2018, DIABETES METAB SYND, V12, P141, DOI 10.1016/j.dsx.2017.12.001
   Panchal SK, 2012, J NUTR, V142, P1026, DOI 10.3945/jn.111.157263
   Parim B, 2019, HEART FAIL REV, V24, P279, DOI 10.1007/s10741-018-9749-1
   Pop C, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9111073
   Prasatthong P, 2021, EUR J NUTR, V60, P833, DOI 10.1007/s00394-020-02291-4
   Qian LB, 2010, PHARMACOL RES, V61, P281, DOI 10.1016/j.phrs.2009.10.004
   Rabie EM, 2015, EUR J PHARMACOL, V760, P145, DOI 10.1016/j.ejphar.2015.04.019
   Ragab SMM, 2015, LIPIDS HEALTH DIS, V14, DOI 10.1186/s12944-015-0087-1
   Ramírez-Higuera A, 2020, J MED FOOD, V23, P305, DOI 10.1089/jmf.2019.0177
   Ramos-Tovar E, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9121279
   Rodríguez-Correa E, 2020, NUTR DIABETES, V10, DOI 10.1038/s41387-020-0127-4
   Roehlen N, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9040875
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Salib JY, 2013, PHARMACOGN RES, V5, P22, DOI 10.4103/0974-8490.105644
   Shahraki Mohammd Reza, 2011, Acta Med Iran, V49, P277
   Shi TH, 2020, PREV CHRONIC DIS, V17, DOI 10.5888/pcd17.200020
   Si HW, 2014, EUR J NUTR, V53, P269, DOI 10.1007/s00394-013-0525-7
   Siasos G, 2013, CURR MED CHEM, V20, P2641, DOI 10.2174/0929867311320210003
   Softic S, 2020, CRIT REV CL LAB SCI, V57, P308, DOI 10.1080/10408363.2019.1711360
   Soliman M.E.-S., 2014, MENOUFIA MED J, V27, P801, DOI [10.4103/1110-2098.132753, DOI 10.4103/1110-2098.149789, 10.4103/1110-2098.149789]
   Spahis S, 2017, ANTIOXID REDOX SIGN, V26, P445, DOI 10.1089/ars.2016.6756
   Stanciu S, 2023, METABOLITES, V13, DOI 10.3390/metabo13010087
   Steenson S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061781
   Suvarna S.K., 2019, Bancroft's Theory And Practice Of Histological Techniques, DOI [10.1016/B978-0-7020-6864-5.00010-4, DOI 10.1016/B978-0-7020-6864-5.00010-4]
   Taskinen MR, 2019, NUTRIENTS, V11, DOI 10.3390/nu11091987
   ter Horst KW, 2017, NUTRIENTS, V9, DOI 10.3390/nu9090981
   Tilg H, 2020, NAT REV GASTRO HEPAT, V17, P387, DOI 10.1038/s41575-020-0316-6
   Tran LT, 2009, MOL CELL BIOCHEM, V332, P145, DOI 10.1007/s11010-009-0184-4
   Upaganlawar A, 2010, INT J PHARMACOL, V6, P645, DOI 10.3923/ijp.2010.645.651
   Venkateshan S, 2016, AVICENNA J PHYTOMEDI, V6, P516
   Wang O, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0118135
   Xiao C, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/2719252
   Xin X, 2020, NUTR METAB, V17, DOI 10.1186/s12986-020-00462-y
   Xu N, 2014, MOL NUTR FOOD RES, V58, P1258, DOI 10.1002/mnfr.201300830
   Zaki MSA, 2020, INT J MORPHOL, V38, P278
   Zaki SM, 2019, FOLIA MORPHOL, V78, P124, DOI 10.5603/FM.a2018.0063
   Zhang DM, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040335
   Zhang YC, 2013, FOOD CHEM TOXICOL, V59, P272, DOI 10.1016/j.fct.2013.05.058
NR 140
TC 2
Z9 2
U1 5
U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0302-766X
EI 1432-0878
J9 CELL TISSUE RES
JI Cell Tissue Res.
PD JAN
PY 2025
VL 399
IS 1
BP 27
EP 60
DI 10.1007/s00441-024-03927-1
EA NOV 2024
PG 34
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA S6U3E
UT WOS:001350179900001
PM 39514020
DA 2025-06-11
ER

PT J
AU Soeiro-de-Souza, MG
   Gold, PW
   Brunoni, AR
   de Sousa, RT
   Zanetti, MV
   Carvalho, AF
   Gattaz, WF
   Machado-Vieira, R
   Teixeira, AL
AF Soeiro-de-Souza, Marcio Gerhardt
   Gold, Philip W.
   Brunoni, Andre R.
   de Sousa, Rafael T.
   Zanetti, Marcus V.
   Carvalho, Andre F.
   Gattaz, Wagner Farid
   Machado-Vieira, Rodrigo
   Teixeira, Antonio Lucio
TI Lithium Decreases Plasma Adiponectin Levels in Bipolar Depression
SO NEUROSCIENCE LETTERS
LA English
DT Article
DE Lithium; Adiponectin; Bipolar; Disorder; Depression; Metabolic;
   Treatment
ID MOOD DISORDERS; LEPTIN; OBESITY; RESISTIN; INFLAMMATION; ADIPOKINES
AB Lithium, a first line treatment for bipolar disorder (BD), has been associated with significant weight gain, but the mechanisms underlying this phenomenon are still unclear. It has been suggested that changes in production/release of adipokines - molecules secreted by adipose tissue presenting anti-inflammatory (adiponectin) and pro-inflammatory (leptin, resistin) properties - might be implicated. Adiponectin, resistin and leptin were assessed in 25 acutely depressed BD individuals (88% medication-free and 68% treatment-naive) at baseline and after 6 weeks of lithium therapy, and in 23 healthy controls matched by age. The 21-item Hamilton Depression Rating Scale was used to assess depression severity. Levels of adiponectin significantly decreased after lithium monotherapy, while the levels of resistin and leptin remained stable after the follow-up period. Adipokine levels during depressive episodes in BD did not differ compared to controls. Pretreatment levels of leptin were higher in remitters and changes in resistin levels were negatively correlated to improvement of depressive symptoms with lithium. Our findings shed light in this pathophysiological process, which might be associated with metabolic syndrome, inflammation and other medical comorbidities in BD. Published by Elsevier Ireland Ltd.
C1 [Soeiro-de-Souza, Marcio Gerhardt] Univ Sao Paulo, Dept & Inst Psychiat, Mood Disorders Unit GRUDA, BR-05508 Sao Paulo, Brazil.
   [Gold, Philip W.; Machado-Vieira, Rodrigo] NIMH, NIH, Bethesda, MD 20892 USA.
   [Brunoni, Andre R.] Univ Sao Paulo, Serv Interdisciplinary Neuromodulat, Interdisciplinary Ctr Appl Neuromodulat, Dept & Inst Psychiat,Univ Hosp, Ribeirao Preto, Brazil.
   [de Sousa, Rafael T.; Zanetti, Marcus V.; Gattaz, Wagner Farid; Machado-Vieira, Rodrigo] Univ Sao Paulo, Dept & Inst Psychiat, Lab Neurosci, BR-05508 Sao Paulo, Brazil.
   [Zanetti, Marcus V.; Gattaz, Wagner Farid; Machado-Vieira, Rodrigo] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, Ribeirao Preto, Brazil.
   [Carvalho, Andre F.] Univ Fed Ceara, Fac Med, Psychiat Res Grp, Fortaleza, Ceara, Brazil.
   [Teixeira, Antonio Lucio] Univ Minas Gerais UFMG, Div Neurol, Neuropsychiat Branch, Belo Horizonte, MG, Brazil.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Mental Health (NIMH); Universidade de Sao Paulo; Universidade Federal do
   Ceara
RP Machado-Vieira, R (corresponding author), Sch Med, Inst & Dept Psychiat, Rua Ovidio Pires de Campos 785, BR-01060970 Sao Paulo, Brazil.
EM marciogss@gmail.com; machadovieirar@gmail.com
RI Gattaz, Wagner/C-4456-2012; Carvalho, Andre/AEZ-4001-2022; Zanetti,
   Marcus/A-9013-2008; Teixeira, Antonio/N-3315-2014; Soeiro-de-Souza,
   M./J-9430-2012; MACHADO-VIEIRA, RODRIGO/D-8293-2012; Russowsky Brunoni,
   Andre/H-8394-2012
OI Teixeira, Antonio Lucio/0000-0002-9621-5422; Gerhardt Soeiro-de-Souza,
   Marcio/0000-0002-9293-3128; MACHADO-VIEIRA, RODRIGO/0000-0002-4830-1190;
   Russowsky Brunoni, Andre/0000-0002-6310-3571
FU Sao Paulo Research Foundation (FAPESP, Brazil) [2009/14891-9]; CNPq;
   Fapemig; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [09/14891-9] Funding Source: FAPESP
FX This study was sponsored by Sao Paulo Research Foundation (FAPESP,
   Brazil) (2009/14891-9), CNPq, and Fapemig.
CR Ahima RS, 2006, OBESITY, V14, p9S, DOI 10.1038/oby.2006.276
   Atmaca M., NEUROPSYCHOBIOLOGY, V46
   Barbosa IG, 2012, J PSYCHIATR RES, V46, P389, DOI 10.1016/j.jpsychires.2011.11.010
   Berg AH, 2005, CIRC RES, V96, P939, DOI 10.1161/01.RES.0000163635.62927.34
   Brunetti L, 2004, EUR J PHARMACOL, V493, P41, DOI 10.1016/j.ejphar.2004.04.020
   Cizza G, 2010, J CLIN PSYCHIAT, V71, P1079, DOI 10.4088/JCP.09m05314blu
   De Hert M, 2009, WORLD PSYCHIATRY, V8, P15
   Elmquist JK, 1998, J COMP NEUROL, V395, P535
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   Fagiolini A, 2003, AM J PSYCHIAT, V160, P112, DOI 10.1176/appi.ajp.160.1.112
   Jamaluddin MS, 2012, BRIT J PHARMACOL, V165, P622, DOI 10.1111/j.1476-5381.2011.01369.x
   Jamison KayRedfield., 2007, Manic-Depressive Illness: Bipolar Disorders and Recurrent Depression, V2nd
   Jow GM, 2006, J AFFECT DISORDERS, V90, P21, DOI 10.1016/j.jad.2005.09.015
   Kemp DE, 2010, BIPOLAR DISORD, V12, P404, DOI 10.1111/j.1399-5618.2010.00823.x
   Kraus T, 2001, NEUROENDOCRINOLOGY, V73, P243, DOI 10.1159/000054641
   Lee EB, 2011, J NEUROSCI, V31, P14361, DOI 10.1523/JNEUROSCI.3171-11.2011
   Lehto SM, 2010, ACTA PSYCHIAT SCAND, V121, P209, DOI 10.1111/j.1600-0447.2009.01463.x
   Leo R, 2006, NEUROSCI LETT, V407, P211, DOI 10.1016/j.neulet.2006.08.043
   Livingstone C, 2006, J PSYCHOPHARMACOL, V20, P347, DOI 10.1177/0269881105057515
   Lu XY, 2007, CURR OPIN PHARMACOL, V7, P648, DOI 10.1016/j.coph.2007.10.010
   Lu XY, 2006, P NATL ACAD SCI USA, V103, P1593, DOI 10.1073/pnas.0508901103
   McElroy SL, 2004, J CLIN PSYCHIAT, V65, P634
   McElroy SL, 2009, J CLIN PSYCHIAT, V70, P12, DOI 10.4088/JCP.7075su1c.03
   Ouchi N, 2003, CURR OPIN LIPIDOL, V14, P561, DOI 10.1097/00041433-200312000-00003
   Ouchi N, 2011, NAT REV IMMUNOL, V11, P85, DOI 10.1038/nri2921
   PESELOW ED, 1980, J AFFECT DISORDERS, V2, P303, DOI 10.1016/0165-0327(80)90031-2
   Steppan CM, 2001, NATURE, V409, P307, DOI 10.1038/35053000
   Torrent C, 2008, ACTA PSYCHIAT SCAND, V118, P4, DOI 10.1111/j.1600-0447.2008.01204.x
   Yatham LN, 2013, BIPOLAR DISORD, V15, P1, DOI 10.1111/bdi.12025
   Yim CY, 2012, EUR PSYCHIAT, V27, P223, DOI 10.1016/j.eurpsy.2011.02.004
   ZHANG YY, 1994, NATURE, V372, P425, DOI 10.1038/372425a0
NR 31
TC 32
Z9 32
U1 0
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0304-3940
EI 1872-7972
J9 NEUROSCI LETT
JI Neurosci. Lett.
PD APR 3
PY 2014
VL 564
BP 111
EP 114
DI 10.1016/j.neulet.2014.02.005
PG 4
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA AF8SK
UT WOS:000334985700022
PM 24525248
DA 2025-06-11
ER

PT J
AU Jackson, SE
   Steptoe, A
AF Jackson, Sarah E.
   Steptoe, Andrew
TI Obesity, perceived weight discrimination, and hair cortisol: a
   population-based study
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Obesity; Weight-related discrimination; Stigma; Stress; Cortisol
ID METABOLIC SYNDROME; SCALP HAIR; STRESS; STIGMA; BIAS; ASSOCIATIONS;
   PREVALENCE; PREDICTORS; REDUCTION; MEDIATION
AB Background and purpose: Stigmatization of individuals with obesity is pervasive and may act as a psychological stressor. The present study examined whether perceived weight discrimination mediated the relationship between obesity and cortisol, an objective marker of chronic stress, in a population-based sample.
   Methods: Data were from the English Longitudinal Study of Ageing (n = 1872). Height and weight were objectively measured in 2008/09. Experiences of weight-related discrimination were reported via questionnaire in 2010/11. Hair cortisol concentrations were determined from the scalp-nearest 2 cm hair segment in 2012/13. Mediation analyses tested the role of perceived weight discrimination in the associations between obesity and BMI and hair cortisol concentration, adjusting for age, sex, ethnicity, socio-economic status, smoking status, depression and hair-related factors.
   Results: Obesity, BMI and perceived weight discrimination were positively related to hair cortisol (all p < .01). Perceived weight discrimination significantly mediated associations between obesity and hair cortisol (beta = 0.021, SE = 0.007, 95% CI 0.007-0.036) and BMI and hair cortisol (beta = 0.001, SE = 0.0004, 95% CI 0.0004-0.002), accounting for 19% of the total effect of obesity and 23% of the total effect of BMI on hair cortisol.
   Conclusions: Perceived weight discrimination is an important mediator of the association between obesity and cortisol. Interventions combating weight stigma and discrimination or promoting strategies for coping with stress could help to lessen the psychological and physiological burden of obesity.
C1 [Jackson, Sarah E.; Steptoe, Andrew] UCL, Dept Behav Sci & Hlth, 1-19 Torrington Pl, London WC1E 6BT, England.
C3 University of London; University College London
RP Jackson, SE (corresponding author), UCL, Dept Behav Sci & Hlth, 1-19 Torrington Pl, London WC1E 6BT, England.
EM s.e.jackson@ucl.ac.uk
RI Steptoe, Andrew/Y-2440-2019; Jackson, Sarah/J-9046-2019
OI Jackson, Sarah/0000-0001-5658-6168
FU Cancer Research UK [C1418/A14133]
FX This work was supported by a grant from Cancer Research UK
   (C1418/A14133).
CR Anagnostis P, 2009, J CLIN ENDOCR METAB, V94, P2692, DOI 10.1210/jc.2009-0370
   Andreyeva T, 2008, OBESITY, V16, P1129, DOI 10.1038/oby.2008.35
   BARON RM, 1986, J PERS SOC PSYCHOL, V51, P1173, DOI 10.1037/0022-3514.51.6.1173
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   Born JM, 2010, INT J OBESITY, V34, P172, DOI 10.1038/ijo.2009.221
   Burkhauser RV, 2008, J HEALTH ECON, V27, P519, DOI 10.1016/j.jhealeco.2007.05.005
   Cohen S, 2007, JAMA-J AM MED ASSOC, V298, P1685, DOI 10.1001/jama.298.14.1685
   Dahl R, 2006, RESP MED, V100, P1307, DOI 10.1016/j.rmed.2005.11.020
   Dallman MF, 2003, P NATL ACAD SCI USA, V100, P11696, DOI 10.1073/pnas.1934666100
   Daníelsdóttir S, 2010, OBESITY FACTS, V3, P47, DOI 10.1159/000277067
   DemakaKos P, 2015, J EPIDEMIOL COMMUNIT, V2015, DOI [10.1136/jedi-2015-206173, DOI 10.1136/JEDI-2015-206173]
   DeRosia ED, STATE CODE PERFORMIN
   Feller S, 2014, PSYCHONEUROENDOCRINO, V39, P132, DOI 10.1016/j.psyneuen.2013.10.007
   Gao W, 2013, J CHROMATOGR B, V928, P1, DOI 10.1016/j.jchromb.2013.03.008
   Gloor JL., 2016, Stigma and Health, V1, P269, DOI DOI 10.1037/SAH0000030
   Groesz LM, 2012, APPETITE, V58, P717, DOI 10.1016/j.appet.2011.11.028
   Hatzenbuehler ML, 2009, OBESITY, V17, P2033, DOI 10.1038/oby.2009.131
   Himmelstein MS, 2015, OBESITY, V23, P368, DOI 10.1002/oby.20959
   Jackson SE, 2015, INT J OBESITY, V39, P858, DOI 10.1038/ijo.2014.186
   Jackson SE, 2017, OBESITY, V25, P539, DOI 10.1002/oby.21733
   Jackson SE, 2016, OBESITY, V24, P2515, DOI 10.1002/oby.21657
   Jackson SE, 2015, OBESITY, V23, P1105, DOI 10.1002/oby.21052
   Jackson SE, 2014, OBESITY, V22, P2485, DOI 10.1002/oby.20891
   Kandiah J, 2006, NUTR RES, V26, P118, DOI 10.1016/j.nutres.2005.11.010
   Kintz P, 2006, THER DRUG MONIT, V28, P442, DOI 10.1097/01.ftd.0000211811.27558.b5
   Lee M, 2014, BODY IMAGE, V11, P251, DOI 10.1016/j.bodyim.2014.03.003
   Manenschijn L, 2011, J CLIN ENDOCR METAB, V96, pE1862, DOI 10.1210/jc.2011-1551
   Manenschijn L, 2011, STEROIDS, V76, P1032, DOI 10.1016/j.steroids.2011.04.005
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Noppe G, 2016, INT J OBESITY, V40, P1503, DOI 10.1038/ijo.2016.113
   Pearl RL, 2017, OBESITY, V25, P317, DOI 10.1002/oby.21716
   Peckett AJ, 2011, METABOLISM, V60, P1500, DOI 10.1016/j.metabol.2011.06.012
   Pervanidou P, 2011, INT J PEDIATR OBES, V6, P21, DOI 10.3109/17477166.2011.615996
   Phinney JS, 1998, J APPL SOC PSYCHOL, V28, P937, DOI 10.1111/j.1559-1816.1998.tb01661.x
   Preacher KJ, 2004, BEHAV RES METH INS C, V36, P717, DOI 10.3758/BF03206553
   Puhl R, 2001, OBES RES, V9, P788, DOI 10.1038/oby.2001.108
   Puhl RM, 2008, INT J OBESITY, V32, P992, DOI 10.1038/ijo.2008.22
   Puhl R, 2015, CURR OBES REP, V4, P182, DOI 10.1007/s13679-015-0153-z
   Puhl RM, 2006, OBESITY, V14, P1802, DOI 10.1038/oby.2006.208
   Puhl RM, 2009, OBESITY, V17, P941, DOI 10.1038/oby.2008.636
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Rodriguez ACI, 2015, PSYCHONEUROENDOCRINO, V62, P301, DOI 10.1016/j.psyneuen.2015.08.014
   Schvey NA, 2014, PSYCHOSOM MED, V76, P156, DOI 10.1097/PSY.0000000000000031
   Seacat JD, 2016, J HEALTH PSYCHOL, V21, P228, DOI 10.1177/1359105314525067
   Shrout PE, 2002, PSYCHOL METHODS, V7, P422, DOI 10.1037//1082-989X.7.4.422
   Sobel M.E., 1982, SOCIOLOGICAL METHODO, P290, DOI DOI 10.2307/270723
   Stalder T, 2017, PSYCHONEUROENDOCRINO, V77, P261, DOI 10.1016/j.psyneuen.2016.12.017
   Stalder T, 2012, BRAIN BEHAV IMMUN, V26, P1019, DOI 10.1016/j.bbi.2012.02.002
   Stalder T, 2012, PSYCHONEUROENDOCRINO, V37, P602, DOI 10.1016/j.psyneuen.2011.08.007
   Steptoe A, 2013, INT J EPIDEMIOL, V42, P1640, DOI 10.1093/ije/dys168
   Tomiyama AJ, 2014, APPETITE, V82, P8, DOI 10.1016/j.appet.2014.06.108
   Tomiyama AJ, 2014, HEALTH PSYCHOL, V33, P862, DOI 10.1037/hea0000107
   Torres SJ, 2007, NUTRITION, V23, P887, DOI 10.1016/j.nut.2007.08.008
   Turvey C L, 1999, Int Psychogeriatr, V11, P139, DOI 10.1017/S1041610299005694
   Vartanian LR, 2014, J CONTEXTUAL BEHAV S, V3, P196, DOI 10.1016/j.jcbs.2014.01.003
   Veldhorst MAB, 2014, J CLIN ENDOCR METAB, V99, P285, DOI 10.1210/jc.2013-2924
   Wester VL, 2014, OBESITY, V22, P1956, DOI 10.1002/oby.20795
   WILLIAMSON DF, 1993, ANN INTERN MED, V119, P646, DOI 10.7326/0003-4819-119-7_Part_2-199310011-00004
NR 58
TC 33
Z9 38
U1 2
U2 26
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD DEC
PY 2018
VL 98
BP 67
EP 73
DI 10.1016/j.psyneuen.2018.08.018
PG 7
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA HA6HR
UT WOS:000450381100010
PM 30118922
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Lehman, BJ
   Taylor, SE
   Kiefe, CI
   Seeman, TE
AF Lehman, BJ
   Taylor, SE
   Kiefe, CI
   Seeman, TE
TI Relation of childhood socioeconomic status and family environment to
   adult metabolic functioning in the CARDIA study
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE stress; family; health; SES; comorbidities; HPA
ID 3RD NATIONAL-HEALTH; NEGATIVE EMOTIONS; PHYSICAL HEALTH; SOCIAL TIES;
   HOSTILITY; STRESS; MEN; CONSEQUENCES; ASSOCIATION; MEDIATORS
AB Objective: Low SES and a conflict-ridden, neglectful, or harsh family environment in childhood have been linked to a high rate of physical health disorders in adulthood. The objective of the present investigation was to evaluate a model of the pathways that may help to explain these links and to relate them to metabolic functioning (MF) in the Coronary Artery Risk Development In Young Adults (CARDIA) dataset. Methods: Participants (n = 3225) in the year 15 assessment of CARDIA, age 33 to 45 years, completed measures of childhood socioeconomic status (SES), risky early family environment (RF), adult psychosocial functioning (PsyF, a latent factor measured by depression, hostility, positive and negative social contacts), and adult SES. Indicators of the latent factor MF were assessed, specifically, cholesterol, insulin, glucose, triglycerides, and waist circumference. Results: The overall prevalence of metabolic syndrome was 9.7%. Structural equation modeling indicated that childhood SES and RF are associated with MF via their association with PsyF (standardized path coefficients: childhood SES to RF -0.13, RF to PsyF 0.44, PsyF to MF 0.09, all p < .05), but also directly (coefficient from childhood SES to MF -0.12,p < .05), with good overall model fit. When this model was tested separately for race-sex subgroups, it fit best for white women, fit well for African-American women and white men, but did not fit well for African-American men. Conclusions: These results indicate that childhood SES and early family environment contribute to metabolic functioning through pathways of depression, hostility, and poor quality of social contacts.
C1 Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA.
   Univ Calif Los Angeles, Dept Geriatr, Los Angeles, CA 90095 USA.
   Univ Alabama Birmingham, Div Prevent Med, Birmingham, AL USA.
   Vet Affairs Med Ctr, Birmingham, AL USA.
   Western Washington Univ, Dept Psychol, Bellingham, WA 98225 USA.
C3 University of California System; University of California Los Angeles;
   University of California System; University of California Los Angeles;
   University of Alabama System; University of Alabama Birmingham; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Western Washington University
RP Univ Calif Los Angeles, Dept Psychol, 1282A Franz Hall, Los Angeles, CA 90095 USA.
EM taylors@psych.ucla.edu
RI Lehman, Barbara/H-4798-2019
OI Lehman, Barbara/0000-0002-2887-3466
FU National Institute of Mental Health [T32MH015750] Funding Source: NIH
   RePORTER; NHLBI NIH HHS [N01-HC-48050, N01-HC-95095, N01-HC-45134,
   N01-HC-48049, N01-HC-48048, N01-HC-05187, N01-HC-48047] Funding Source:
   Medline; NIMH NIH HHS [MH15750] Funding Source: Medline
CR Adler NE, 2000, HEALTH PSYCHOL, V19, P586, DOI 10.1037/0278-6133.19.6.586
   ADLER NE, 1993, JAMA-J AM MED ASSOC, V269, P3140, DOI 10.1001/jama.269.24.3140
   Bachorik P S, 1986, Methods Enzymol, V129, P78
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   Chen E, 2002, PSYCHOL BULL, V128, P295, DOI 10.1037/0033-2909.128.2.295
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   COHEN, IN PRESS PSYCHOSOM M
   Cohen S, 1997, JAMA-J AM MED ASSOC, V277, P1940
   Cutter G R, 1991, Control Clin Trials, V12, p1S, DOI 10.1016/0197-2456(91)90002-4
   Dallongeville J, 2004, ANN NUTR METAB, V48, P43, DOI 10.1159/000075304
   DEMBROSKI TM, 1985, PSYCHOSOM MED, V47, P219, DOI 10.1097/00006842-198505000-00001
   DODGE KA, 1994, CHILD DEV, V65, P649, DOI 10.1111/j.1467-8624.1994.tb00774.x
   Emery RE, 1998, AM PSYCHOL, V53, P121, DOI 10.1037/0003-066X.53.2.121
   Evans GW, 2004, AM PSYCHOL, V59, P77, DOI 10.1037/0003-066X.59.2.77
   Feldman PJ, 2003, HEALTH PSYCHOL, V22, P398, DOI 10.1037/0278-6133.22.4.398
   Felitti VJ, 1998, AM J PREV MED, V14, P245, DOI 10.1016/S0749-3797(98)00017-8
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   FRASURESMITH N, 1995, HEALTH PSYCHOL, V14, P388, DOI 10.1037/0278-6133.14.5.388
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   FRIEDMAN GD, 1988, J CLIN EPIDEMIOL, V41, P1105, DOI 10.1016/0895-4356(88)90080-7
   Gallo LC, 2003, PSYCHOL BULL, V129, P10, DOI 10.1037//0033-2909.129.1.10
   Groop L, 2001, J INTERN MED, V250, P105, DOI 10.1046/j.1365-2796.2001.00864.x
   HERBERT TB, 1993, PSYCHOL BULL, V113, P472, DOI 10.1037/0033-2909.113.3.472
   HOUSE JS, 1988, SCIENCE, V241, P540, DOI 10.1037/0003-066X.59.8.676
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lindblad U, 2001, AM J EPIDEMIOL, V153, P481, DOI 10.1093/aje/153.5.481
   MARTIN LR, 1995, HEALTH PSYCHOL, V14, P381, DOI 10.1037/0278-6133.14.5.381
   McDonald RP, 2002, PSYCHOL METHODS, V7, P64, DOI 10.1037//1082-989X.7.1.64
   McEwen BS, 1999, ANN NY ACAD SCI, V896, P30, DOI 10.1111/j.1749-6632.1999.tb08103.x
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   McLoyd VC, 1998, AM PSYCHOL, V53, P185, DOI 10.1037/0003-066X.53.2.185
   Niaura R, 2002, HEALTH PSYCHOL, V21, P588, DOI 10.1037//0278-6133.21.6.588
   RADLOFF LS, 1977, APPL PSYCH MEAS, V1, P105
   Räikkönen K, 2003, HEALTH PSYCHOL, V22, P279, DOI 10.1037/0278-6133.22.3.279
   Repetti RL, 2002, PSYCHOL BULL, V128, P330, DOI 10.1037/0033-2909.128.2.330
   Russek LG, 1997, J BEHAV MED, V20, P1, DOI 10.1023/A:1025525428213
   Satorra A., 1994, LATENT VARIABLES ANA, P399, DOI DOI 10.2307/2291370
   SCHUSTER TL, 1990, AM J COMMUN PSYCHOL, V18, P423, DOI 10.1007/BF00938116
   Seeman TE, 1997, ARCH INTERN MED, V157, P2259
   Seeman TE, 1996, ANN EPIDEMIOL, V6, P442, DOI 10.1016/S1047-2797(96)00095-6
   SLEIN MW, 1950, J BIOL CHEM, V186, P763
   Spielberger CD., 1999, The use of psychological testing for treatment planning and outcomes assessment, V2, P993, DOI DOI 10.1002/9780470479216.CORPSY0943
   Taylor S.E., 2000, Socioeconomic status and health in industrial nations: social, psychological and biological pathways, P210
   Taylor SE, 2004, J PERS, V72, P1365, DOI 10.1111/j.1467-6494.2004.00300.x
   Trevisan M, 1998, AM J EPIDEMIOL, V148, P958
   Walker EA, 1999, AM J MED, V107, P332, DOI 10.1016/S0002-9343(99)00235-1
   Warnick G R, 1986, Methods Enzymol, V129, P101
   WARNICK GR, 1982, CLIN CHEM, V28, P1379
NR 49
TC 142
Z9 163
U1 0
U2 19
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD NOV-DEC
PY 2005
VL 67
IS 6
BP 846
EP 854
DI 10.1097/01.psy.0000188443.48405.eb
PG 9
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 989QZ
UT WOS:000233690100004
PM 16314588
DA 2025-06-11
ER

PT J
AU Ehrlich, KB
AF Ehrlich, Katherine B.
TI How Does the Social World Shape Health Across the Lifespan? Insights and
   New Directions
SO AMERICAN PSYCHOLOGIST
LA English
DT Article
DE social determinants of health; stress; health disparities; inflammation;
   chronic disease
ID ADVERSE CHILDHOOD EXPERIENCES; ANTIBODY-RESPONSE; INFLUENZA VACCINATION;
   SOCIOECONOMIC-STATUS; METABOLIC SYNDROME; IMMUNE-RESPONSE;
   SEX-DIFFERENCES; YOUNG; INFLAMMATION; DEPRESSION
AB Decades of research highlight the connections between stressful life experiences-particularly those experienced in childhood-and physical health across the lifespan. In recent years, studies at the intersection of social and biomedical science have provided intriguing insights into the biological mechanisms that might explain how chronic and acute stressors give rise to health problems, sometimes decades later in life. To date, efforts to understand these connections have relied on a handful of study designs, and these studies have revealed important observations about how stressful experiences are thought to shape health. At the same time, these study designs have some drawbacks that limit the conclusions that can be drawn about the role of the social world for health. This article provides an overview of research on social determinants of health and includes a discussion of conceptual and methodological directions for the field to consider.
C1 [Ehrlich, Katherine B.] Univ Georgia, Dept Psychol, 125 Baldwin St, Athens, GA 30602 USA.
   [Ehrlich, Katherine B.] Univ Georgia, Ctr Family Res, Athens, GA 30602 USA.
C3 University System of Georgia; University of Georgia; University System
   of Georgia; University of Georgia
RP Ehrlich, KB (corresponding author), Univ Georgia, Dept Psychol, 125 Baldwin St, Athens, GA 30602 USA.
EM kehrlich@uga.edu
OI Ehrlich, Katherine/0000-0002-8958-6161
FU NIH Common Fund [DP2 MD013947]; Jacobs Foundation (Early Career Research
   Fellowship) [2018-1288-07]; Brain and Behavior Research Foundation
   [27302]
FX I am grateful to Kelsey L. Corallo and Sarah M. Lyle for their helpful
   comments on a draft of this article. Preparation of this article was
   supported by the NIH Common Fund (DP2 MD013947), the Jacobs Foundation
   (Early Career Research Fellowship, 2018-1288-07), and the Brain and
   Behavior Research Foundation (Young Investigator Grant 27302).
CR Agency for Healthcare Research and Quality, 2018, 2018 NAT HEALTHC QUA
   Allen JP, 2018, DEV PSYCHOPATHOL, V30, P1435, DOI 10.1017/S0954579417001754
   Allen JP, 2015, PSYCHOL SCI, V26, P1574, DOI 10.1177/0956797615594118
   [Anonymous], 2016, DEV PSYCHOPATHOLOGY, DOI DOI 10.1002/9781119125556.DEVPSY311
   Arnett MJ, 2016, J URBAN HEALTH, V93, P456, DOI 10.1007/s11524-016-0054-9
   Baldwin JR, 2019, JAMA PSYCHIAT, V76, P584, DOI 10.1001/jamapsychiatry.2019.0097
   Baldwin JR, 2018, BRAIN BEHAV IMMUN, V67, P211, DOI 10.1016/j.bbi.2017.08.025
   BARKER DJP, 1990, BRIT MED J, V301, P1111, DOI 10.1136/bmj.301.6761.1111
   Bernard K, 2019, PEDIATR OBES, V14, DOI 10.1111/ijpo.12510
   Bernard K, 2019, ATTACH HUM DEV, V21, P5, DOI 10.1080/14616734.2018.1541513
   Blakemore SJ, 2007, PSYCHOLOGIST, V20, P600
   Bloom B., 2012, Summary health statistics for U.S. children: National health interview survey
   Bowker JC, 2010, J SOC PERS RELAT, V27, P707, DOI 10.1177/0265407510373259
   Brody GH, 2018, HEALTH PSYCHOL, V37, P1107, DOI 10.1037/hea0000674
   Brody GH, 2017, PREV MED, V100, P117, DOI 10.1016/j.ypmed.2017.04.017
   Brody GH, 2016, PEDIATRICS, V138, DOI 10.1542/peds.2016-1042
   Burns VE, 2003, J PSYCHOSOM RES, V55, P569, DOI 10.1016/S0022-3999(03)00073-4
   Busse WW, 2001, NEW ENGL J MED, V344, P350, DOI 10.1056/NEJM200102013440507
   Busso DS, 2017, PSYCHOSOM MED, V79, P162, DOI 10.1097/PSY.0000000000000369
   Cardel Michelle, 2011, Open Obes J, V3, P17
   Centers for Disease Control and Prevention, 2018, HIV SURV REP
   Centers for Disease Control and Prevention, 2019, HLTH US
   Chen E, 2011, MOL PSYCHIATR, V16, P729, DOI 10.1038/mp.2010.53
   Chen E, 2008, IMMUNOL ALLERGY CLIN, V28, P649, DOI 10.1016/j.iac.2008.03.007
   Chen E, 2006, J ALLERGY CLIN IMMUN, V117, P1014, DOI 10.1016/j.jaci.2006.01.036
   Chen E, 2013, CHILD DEV, V84, P1241, DOI 10.1111/cdev.12037
   Claussen B, 2003, J EPIDEMIOL COMMUN H, V57, P40, DOI 10.1136/jech.57.1.40
   Cornier MA, 2008, ENDOCR REV, V29, P777, DOI 10.1210/er.2008-0024
   Crouch JL, 2000, J COMMUNITY PSYCHOL, V28, P625, DOI 10.1002/1520-6629(200011)28:6<625::AID-JCOP6>3.0.CO;2-R
   Danese A, 2009, ARCH PEDIAT ADOL MED, V163, P1135, DOI 10.1001/archpediatrics.2009.214
   Duncan GE, 2004, DIABETES CARE, V27, P2438, DOI 10.2337/diacare.27.10.2438
   Ehrlich K. B., 2020, MALTREATMENT E UNPUB
   Ehrlich KB, 2019, CHILD DEV, V90, pE718, DOI 10.1111/cdev.13098
   Ehrlich KB, 2019, CHILD DEV, V90, P1272, DOI 10.1111/cdev.13003
   Ehrlich KB, 2016, DEV PSYCHOPATHOL, V28, P1273, DOI 10.1017/S0954579416000845
   Ehrlich KB, 2015, DEV PSYCHOPATHOL, V27, P1547, DOI 10.1017/S0954579415000930
   Ehrlich KB, 2015, HEALTH PSYCHOL, V34, P896, DOI 10.1037/hea0000213
   Farrell AK, 2019, ATTACH HUM DEV, V21, P70, DOI 10.1080/14616734.2018.1541517
   Felitti VJ, 1998, AM J PREV MED, V14, P245, DOI 10.1016/S0749-3797(98)00017-8
   Field T, 2004, INFANT BEHAV DEV, V27, P216, DOI 10.1016/j.infbeh.2003.09.010
   Furman D, 2014, P NATL ACAD SCI USA, V111, P869, DOI 10.1073/pnas.1321060111
   Gluckman PD, 2006, DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, P33, DOI 10.1017/CBO9780511544699.004
   Gordon AM, 2019, PSYCHOSOM MED, V81, P739, DOI 10.1097/PSY.0000000000000669
   Goyal MK, 2020, PEDIATRICS, V146, DOI 10.1542/peds.2020-009951
   Hagiwara N, 2013, SOC SCI MED, V87, P123, DOI 10.1016/j.socscimed.2013.03.016
   Hardt J, 2004, J CHILD PSYCHOL PSYC, V45, P260, DOI 10.1111/j.1469-7610.2004.00218.x
   Heijmans BT, 2008, P NATL ACAD SCI USA, V105, P17046, DOI 10.1073/pnas.0806560105
   Janicki-Deverts D, 2014, BRAIN BEHAV IMMUN, V40, P174, DOI 10.1016/j.bbi.2014.03.010
   Kaugars AS, 2004, J PEDIATR PSYCHOL, V29, P475, DOI 10.1093/jpepsy/jsh051
   Kiecolt-Glaser JK, 2009, PERSPECT PSYCHOL SCI, V4, P367, DOI 10.1111/j.1745-6924.2009.01139.x
   Klein SL, 2016, NAT REV IMMUNOL, V16, P626, DOI 10.1038/nri.2016.90
   Krause N, 1998, J AGING HEALTH, V10, P395, DOI 10.1177/089826439801000401
   Larson MR, 2002, PSYCHOSOM MED, V64, P113
   Lule E., 2006, DIS CONTROL PRIORITI, V2nd, P217
   McLaughlin KA, 2014, NEUROSCI BIOBEHAV R, V47, P578, DOI 10.1016/j.neubiorev.2014.10.012
   Miller G, 2009, ANNU REV PSYCHOL, V60, P501, DOI 10.1146/annurev.psych.60.110707.163551
   Miller GE, 2016, HEALTH PSYCHOL, V35, P1225, DOI 10.1037/hea0000398
   Miller GE, 2014, P NATL ACAD SCI USA, V111, P11287, DOI 10.1073/pnas.1406578111
   Miller GE, 2011, PSYCHOL SCI, V22, P1591, DOI 10.1177/0956797611419170
   Nathan C, 2010, CELL, V140, P871, DOI 10.1016/j.cell.2010.02.029
   O'Connor TG, 2015, BRAIN BEHAV IMMUN, V48, P265, DOI 10.1016/j.bbi.2015.04.002
   O'Connor TG, 2014, DEV PSYCHOPATHOL, V26, P1567, DOI 10.1017/S0954579414001242
   O'Connor TG, 2013, BRAIN BEHAV IMMUN, V32, P21, DOI 10.1016/j.bbi.2013.02.002
   Pedersen AF, 2009, BRAIN BEHAV IMMUN, V23, P427, DOI 10.1016/j.bbi.2009.01.004
   Repetti RL, 2002, PSYCHOL BULL, V128, P330, DOI 10.1037/0033-2909.128.2.330
   Reuben A, 2016, J CHILD PSYCHOL PSYC, V57, P1103, DOI 10.1111/jcpp.12621
   Richardson LD, 2010, MT SINAI J MED, V77, P166, DOI 10.1002/msj.20174
   Rieker P. P., 2005, Journals of Gerontology. Series B, Psychological Sciences and Social Sciences, V60, pS40
   Sandman CA, 2012, PSYCHOL SCI, V23, P93, DOI 10.1177/0956797611422073
   Segerstrom SC, 2008, BRAIN BEHAV IMMUN, V22, P744, DOI 10.1016/j.bbi.2007.11.004
   Shalowitz MU, 2001, AMBUL PEDIATR, V1, P185, DOI 10.1367/1539-4409(2001)001<0185:TROLSA>2.0.CO;2
   Shonkoff JP, 2012, PEDIATRICS, V129, pE232, DOI 10.1542/peds.2011-2663
   U.S. Department of Labor Bureau of Labor Statistics, 2019, JOB FLEX WORK SCHED
   Wang YF, 2020, INT J EPIDEMIOL, V49, P810, DOI 10.1093/ije/dyz273
   Yancy CW, 2020, JAMA-J AM MED ASSOC, V323, P1891, DOI 10.1001/jama.2020.6548
   Young ES, 2021, DEV PSYCHOPATHOL, V33, P301, DOI 10.1017/S0954579419001779
NR 76
TC 5
Z9 5
U1 1
U2 5
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0003-066X
EI 1935-990X
J9 AM PSYCHOL
JI Am. Psychol.
PD DEC
PY 2020
VL 75
IS 9
BP 1231
EP 1241
DI 10.1037/amp0000757
PG 11
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA PO1FB
UT WOS:000604915200010
PM 33382288
OA hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Viscogliosi, G
   Donfrancesco, C
   Palmieri, L
   Giampaoli, S
AF Viscogliosi, Giovanni
   Donfrancesco, Chiara
   Palmieri, Luigi
   Giampaoli, Simona
TI The metabolic syndrome and 10-year cognitive and functional decline in
   very old men. A population-based study
SO ARCHIVES OF GERONTOLOGY AND GERIATRICS
LA English
DT Article
DE Metabolic syndrome; Cognitive decline; Functional disability; Incidence
ID ASSOCIATION; HEALTH; RISK; DEPRESSION; IMPAIRMENT; DISABILITY; FRAILTY;
   LIFE; AGE
AB Objectives: To describe longitudinal relationships of metabolic syndrome (MetS) to cognitive decline and functional disability in a sample of older non-institutionalized men.
   Methods: data from 1991 to 2000 of the Italian cohorts of the Finland, Italy, the Netherlands, Elderly (FINE) study, were used. Global cognitive function and functional disability, defined as limitations in mobility, basic (ADLs) and instrumental activities of daily living (IADLs) were screened in 1991 and 2000. MetS was defined according to the NCEP ATP-III criteria.
   Results: The study sample consisted of 195 men, baseline age 76.1 +/- 3.1 years. Baseline MetS was prospectively associated with greater 10-year cognitive and functional decline in ADLs and IADLs. After multiple adjustment including age, education, marital status, ApoE epsilon 4 allele, cerebrovascular disease and initial cognitive and depressive status, MetS predicted cognitive decline (B = - 1.684, 95% CI = - 2.202 to - 1.167, p < 0.001) and risk of IADLs (OR = 1.09, 95% CI = 1.01-1.20, p = 0.048) and ADLs disability (OR = 1.35, 95% CI = 1.12-1.62, p < 0.001). Interestingly, such associations were not attributable to individual altered components of MetS nor to their sum. Incident disability in ADLs and IADLs were not explained by parallel decline in cognitive function.
   Conclusions: MetS as an entity was associated with accelerated cognitive and functional decline in a population-based sample of very old men. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Viscogliosi, Giovanni; Donfrancesco, Chiara; Palmieri, Luigi; Giampaoli, Simona] Natl Inst Hlth, Dept Epidemiol Surveillance & Promot Hlth, Rome, Italy.
   [Viscogliosi, Giovanni] Sapienza Univ, Dept Cardiovasc Resp Nephrol Anesthesiol & Geriat, Dept Gerontol, Rome, Italy.
C3 Istituto Superiore di Sanita (ISS); Sapienza University Rome
RP Viscogliosi, G (corresponding author), Sapienza Univ, Via Giano Della Bella 34, I-00162 Rome, Italy.
EM giovanni.viscogliosi@libero.it
RI donfrancesco, chiara/K-1460-2016; Palmieri, Luigi/O-1845-2017
OI donfrancesco, chiara/0000-0002-8040-5571; Palmieri,
   Luigi/0000-0002-4298-2642
FU CUORE Project - Epidemiology of Cardiovascular diseases - Italian
   National Institute of Health
FX The Italian section of the FINE study was supported by the CUORE Project
   - Epidemiology of Cardiovascular diseases, supported by the Italian
   National Institute of Health.
CR Blazer DG, 2006, J AM GERIATR SOC, V54, P502, DOI 10.1111/j.1532-5415.2005.00607.x
   Carriere I, 2014, J GERONTOL A-BIOL, V69, P79, DOI 10.1093/gerona/glt101
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   FOLSTEIN MF, 1975, J PSYCHIAT RES, V12, P189, DOI 10.1016/0022-3956(75)90026-6
   Giampaoli S, 1999, AGE AGEING, V28, P283, DOI 10.1093/ageing/28.3.283
   Gorelick PB, 2011, STROKE, V42, P2672, DOI 10.1161/STR.0b013e3182299496
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Hoppmann C, 2009, GERONTOLOGY, V55, P449, DOI 10.1159/000211948
   Kim B, 2015, EXP MOL MED, V47, DOI 10.1038/emm.2015.3
   Lin F, 2015, INT J GERIATR PSYCH, V30, P64, DOI 10.1002/gps.4115
   Liu CL, 2013, J NUTR HEALTH AGING, V17, P523, DOI 10.1007/s12603-013-0010-2
   Menotti A, 2001, EUR HEART J, V22, P573, DOI 10.1053/euhj.2000.2402
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Penninx BWJH, 2009, J GERONTOL A-BIOL, V64, P96, DOI 10.1093/gerona/gln005
   Roriz-Cruz M, 2007, J AM GERIATR SOC, V55, P374, DOI 10.1111/j.1532-5415.2007.01068.x
   Siervo M, 2014, J ALZHEIMERS DIS, V41, P151, DOI 10.3233/JAD-132279
   Stenholm S, 2010, J GERONTOL A-BIOL, V65, P84, DOI 10.1093/gerona/glp150
   Viscogliosi G., 2015, PSYCHIAT CLIN NEUROS, V106, P92
   Viscogliosi G, 2016, AM J GERIAT PSYCHIAT, V24, P359, DOI 10.1016/j.jagp.2015.09.001
   Viscogliosi G, 2016, J AM MED DIR ASSOC, V17, P364, DOI 10.1016/j.jamda.2016.01.005
   Yaffe K, 2007, J AM GERIATR SOC, V55, P758, DOI 10.1111/j.1532-5415.2007.01139.x
   ZUNG WWK, 1965, SELF RAT DEPR SCAL, V12, P63
NR 22
TC 19
Z9 20
U1 0
U2 7
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-4943
EI 1872-6976
J9 ARCH GERONTOL GERIAT
JI Arch. Gerontol. Geriatr.
PD MAY-JUN
PY 2017
VL 70
BP 62
EP 66
DI 10.1016/j.archger.2016.12.008
PG 5
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA ES4EF
UT WOS:000399481500009
PM 28076836
DA 2025-06-11
ER

PT J
AU Alemany, M
AF Alemany, Maria
TI Utilization of dietary glucose in the metabolic syndrome
SO NUTRITION & METABOLISM
LA English
DT Review
DE metabolic syndrome; insulin resistance; adipose tissue; hyperlipidemia;
   glycolysis; glucose fate
ID BROWN ADIPOSE-TISSUE; INDUCED INSULIN-RESISTANCE; FATTY LIVER-DISEASE;
   DENSITY-LIPOPROTEIN CHOLESTEROL; ENDOPLASMIC-RETICULUM STRESS; HUMAN
   SKELETAL-MUSCLE; DE-NOVO LIPOGENESIS; LACTATE PRODUCTION; FOOD-INTAKE;
   RAT-LIVER
AB This review is focused on the fate of dietary glucose under conditions of chronically high energy (largely fat) intake, evolving into the metabolic syndrome. We are adapted to carbohydrate-rich diets similar to those of our ancestors. Glucose is the main energy staple, but fats are our main energy reserves. Starvation drastically reduces glucose availability, forcing the body to shift to fatty acids as main energy substrate, sparing glucose and amino acids. We are not prepared for excess dietary energy, our main defenses being decreased food intake and increased energy expenditure, largely enhanced metabolic activity and thermogenesis. High lipid availability is a powerful factor decreasing glucose and amino acid oxidation. Present-day diets are often hyperenergetic, high on lipids, with abundant protein and limited amounts of starchy carbohydrates. Dietary lipids favor their metabolic processing, saving glucose, which additionally spares amino acids. The glucose excess elicits hyperinsulinemia, which may derive, in the end, into insulin resistance. The available systems of energy disposal could not cope with the excess of substrates, since they are geared for saving not for spendthrift, which results in an unbearable overload of the storage mechanisms. Adipose tissue is the last energy sink, it has to store the energy that cannot be used otherwise. However, adipose tissue growth also has limits, and the excess of energy induces inflammation, helped by the ineffective intervention of the immune system. However, even under this acute situation, the excess of glucose remains, favoring its final conversion to fat. The sum of inflammatory signals and deranged substrate handling induce most of the metabolic syndrome traits: insulin resistance, obesity, diabetes, liver steatosis, hyperlipidemia and their compounded combined effects. Thus, a maintained excess of energy in the diet may result in difficulties in the disposal of glucose, eliciting inflammation and the development of the metabolic syndrome
C1 [Alemany, Maria] Univ Barcelona, Fac Biol, Dept Nutr & Food Sci, Barcelona, Spain.
   [Alemany, Maria] Inst Hlth Carlos III, CIBER Obes & Nutr, Madrid, Spain.
C3 University of Barcelona; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN
RP Alemany, M (corresponding author), Univ Barcelona, Fac Biol, Dept Nutr & Food Sci, Barcelona, Spain.
EM malemany@ub.edu
RI Alemany, Maria/H-5224-2011
OI Alemany, Maria/0000-0002-9783-8293
FU Government of Spain [SAF2009-11739]
FX Supported by grant SAF2009-11739 of the Plan Nacional de Investigacion
   en Biomedicina of the Government of Spain.
CR Aarsland A, 1997, AM J CLIN NUTR, V65, P1774, DOI 10.1093/ajcn/65.6.1774
   Alemany M, 2011, J CLIN ENDOCR METAB, V96, P66, DOI 10.1210/jc.2010-2541
   Alemany M, 2006, CURR NUTR FOOD SCI, V2, P141, DOI 10.2174/157340106776818817
   Alenezi MY, 2004, J CLIN ENDOCR METAB, V89, P761, DOI 10.1210/jc.2003-031213
   Anthony K, 2006, DIABETES, V55, P2986, DOI 10.2337/db06-0376
   Ardevol A, 1996, INT J OBESITY, V20, P837
   Aridor M, 1999, NAT MED, V5, P745, DOI 10.1038/10466
   ATRENS DM, 1987, BRAIN RES BULL, V18, P303, DOI 10.1016/0361-9230(87)90007-4
   Attie AD, 2009, J LIPID RES, V50, pS395, DOI 10.1194/jlr.R800057-JLR200
   Ayyobi AF, 2003, AM J CARDIOL, V92, p27J, DOI 10.1016/S0002-9149(03)00613-1
   AZAIN MJ, 1989, AM J PHYSIOL, V257, pR822, DOI 10.1152/ajpregu.1989.257.4.R822
   Barb CR, 2004, DOMEST ANIM ENDOCRIN, V26, P201, DOI 10.1016/j.domaniend.2003.10.004
   BARZILAI N, 1993, J BIOL CHEM, V268, P25019
   BELL RM, 1981, J LIPID RES, V22, P391
   Beneke G, 1973, ACTA ENDOCRINOL-COP, V71, pS174
   BJORNTORP P, 1976, FRONT MATRIX BIOL, V2, P37
   Blundell JE, 1996, ANNU REV NUTR, V16, P285, DOI 10.1146/annurev.nutr.16.1.285
   Bobyleva V, 1998, FEBS LETT, V430, P409, DOI 10.1016/S0014-5793(98)00700-5
   BODY DR, 1988, PROG LIPID RES, V27, P39, DOI 10.1016/0163-7827(88)90004-5
   BOULTON KL, 1992, METABOLISM, V41, P556, DOI 10.1016/0026-0495(92)90219-Z
   Bozzini C, 2005, DIABETES CARE, V28, P2061, DOI 10.2337/diacare.28.8.2061
   Bruce CR, 2005, DIABETES, V54, P3154, DOI 10.2337/diabetes.54.11.3154
   Cahill GF, 2006, ANNU REV NUTR, V26, P1, DOI 10.1146/annurev.nutr.26.061505.111258
   Cancello R, 2006, BJOG-INT J OBSTET GY, V113, P1141, DOI 10.1111/j.1471-0528.2006.01004.x
   CHRISTLIEB AR, 1987, AM J CARDIOL, V60, pI61
   Cinti S, 2005, PROSTAG LEUKOTR ESS, V73, P9, DOI 10.1016/j.plefa.2005.04.010
   Civitarese AE, 2006, CELL METAB, V4, P75, DOI 10.1016/j.cmet.2006.05.002
   COSTA G, 1968, NATURE, V218, P546, DOI 10.1038/218546a0
   de Luis DA, 2008, DIABETES RES CLIN PR, V79, P74, DOI 10.1016/j.diabres.2007.07.015
   de Meijer VE, 2010, METABOLISM, V59, P1092, DOI 10.1016/j.metabol.2009.11.006
   Desco MC, 2002, DIABETES, V51, P1118, DOI 10.2337/diabetes.51.4.1118
   DESPRES JP, 1993, NUTRITION, V9, P452
   DIGIROLAMO M, 1992, FASEB J, V6, P2405, DOI 10.1096/fasebj.6.7.1563593
   Diraison F, 2002, AM J PHYSIOL-ENDOC M, V282, pE46, DOI 10.1152/ajpendo.2002.282.1.E46
   Duffaut C, 2009, BIOCHEM BIOPH RES CO, V384, P482, DOI 10.1016/j.bbrc.2009.05.002
   Eaton SB, 2000, EUR J NUTR, V39, P67, DOI 10.1007/s003940070032
   EATON SB, 1985, NEW ENGL J MED, V312, P283, DOI 10.1056/NEJM198501313120505
   EFENDIC S, 1974, DIABETES, V23, P161, DOI 10.2337/diab.23.3.161
   ELIA M, 1990, CLIN SCI, V78, P579, DOI 10.1042/cs0780579
   Engeli S, 2000, HYPERTENSION, V35, P1270, DOI 10.1161/01.HYP.35.6.1270
   ERNSTER L, 1962, J CELL BIOL, V15, P541, DOI 10.1083/jcb.15.3.541
   ESTEVE M, 1992, INT J OBESITY, V16, P237
   ESTEVE M, 1993, BIOCHEM MOL BIOL INT, V29, P1069
   Faintrenie G, 1996, AM J PHYSIOL-CELL PH, V270, pC1061, DOI 10.1152/ajpcell.1996.270.4.C1061
   FELBER JP, 1988, DIABETES METAB REV, V4, P691, DOI 10.1002/dmr.5610040706
   FELIG P, 1969, J CLIN INVEST, V48, P584, DOI 10.1172/JCI106017
   FELIG P, 1969, NEW ENGL J MED, V281, P811, DOI 10.1056/NEJM196910092811503
   Flamment M, 2010, CURR OPIN LIPIDOL, V21, P239, DOI 10.1097/MOL.0b013e3283395e5c
   Flint A, 2006, AM J CLIN NUTR, V84, P1365, DOI 10.1093/ajcn/84.6.1365
   Foster DL, 1999, BIOL REPROD, V60, P205, DOI 10.1095/biolreprod60.2.205
   FOSTER DO, 1978, CAN J PHYSIOL PHARM, V56, P110, DOI 10.1139/y78-015
   Francini F, 2009, CAN J PHYSIOL PHARM, V87, P702, DOI [10.1139/Y09-064, 10.1139/y09-064]
   Lambert APF, 2009, DIFFERENTIATION, V77, P221, DOI 10.1016/j.diff.2008.10.016
   Frayn KN, 2002, DIABETOLOGIA, V45, P1201, DOI 10.1007/s00125-002-0873-y
   FREDHOLM BB, 1970, ACTA PHYSIOL SCAND, V79, P564, DOI 10.1111/j.1748-1716.1970.tb04759.x
   Freedland Eric S, 2004, Nutr Metab (Lond), V1, P12, DOI 10.1186/1743-7075-1-12
   GEELEN MJH, 1984, FEBS LETT, V175, P8, DOI 10.1016/0014-5793(84)80558-X
   Gertow K, 2006, EUR J CLIN NUTR, V60, P1406, DOI 10.1038/sj.ejcn.1602471
   Girardier L., 1983, P50
   Grattagliano I, 2008, J NUTR BIOCHEM, V19, P491, DOI 10.1016/j.jnutbio.2007.06.011
   Griffin ME, 1999, DIABETES, V48, P1270, DOI 10.2337/diabetes.48.6.1270
   Guerrero-Romero F, 2002, ACTA DIABETOL, V39, P209, DOI 10.1007/s005920200036
   Gylling H, 2007, TRANSL RES, V149, P310, DOI 10.1016/j.trsl.2006.11.012
   Haag M, 2005, MED SCI MONITOR, V11, pRA359
   HAGSTROM E, 1990, AM J PHYSIOL, V258, pE888, DOI 10.1152/ajpendo.1990.258.5.E888
   HARVEY JW, 1976, J CELL PHYSIOL, V89, P219, DOI 10.1002/jcp.1040890205
   HATTORI K, 1991, HUM BIOL, V63, P53
   Heckler BK, 1997, AM J PHYSIOL-ENDOC M, V272, pE957, DOI 10.1152/ajpendo.1997.272.6.E957
   HELLERSTEIN MK, 1991, J CLIN INVEST, V87, P1841, DOI 10.1172/JCI115206
   Hellerstein MK, 1999, EUR J CLIN NUTR, V53, pS53, DOI 10.1038/sj.ejcn.1600744
   Henrichot E, 2005, ARTERIOSCL THROM VAS, V25, P2594, DOI 10.1161/01.ATV.0000188508.40052.35
   HERZBERG GR, 1988, BRIT J NUTR, V59, P233, DOI 10.1079/BJN19880030
   HIGGINS JA, 1984, J LIPID RES, V25, P1295
   HILPERT P, 1963, AM J PHYSIOL, V205, P337, DOI 10.1152/ajplegacy.1963.205.2.337
   HIRSCH J, 1969, J LIPID RES, V10, P77
   Hoffstedt J, 2004, J CLIN ENDOCR METAB, V89, P1391, DOI 10.1210/jc.2003-031458
   HOLNESS MJ, 1988, BIOCHEM J, V252, P325, DOI 10.1042/bj2520325
   Hosogai N, 2007, DIABETES, V56, P901, DOI 10.2337/db06-0911
   Hwu CM, 2009, QJM-INT J MED, V102, P705, DOI 10.1093/qjmed/hcp107
   Iannuzzi A, 2009, HEART VESSELS, V24, P419, DOI 10.1007/s00380-008-1138-6
   Ichiki T, 2010, CIRC J, V74, P1300, DOI 10.1253/circj.CJ-10-0466
   IOSSA S, 1991, J ENDOCRINOL, V131, P67, DOI 10.1677/joe.0.1310067
   JANSKY L, 1995, PHYSIOL REV, V75, P237, DOI 10.1152/physrev.1995.75.2.237
   JENKINS DJA, 1987, AM J CLIN NUTR, V46, P968, DOI 10.1093/ajcn/46.6.968
   Jeppesen J, 2006, ATHEROSCLEROSIS, V189, P369, DOI 10.1016/j.atherosclerosis.2005.12.010
   Juge-Aubry CE, 2005, BEST PRACT RES CL EN, V19, P547, DOI 10.1016/j.beem.2005.07.009
   JUNGAS RL, 1964, BIOCHEMISTRY-US, V3, P1696, DOI 10.1021/bi00899a017
   Kabashima T, 2003, P NATL ACAD SCI USA, V100, P5107, DOI 10.1073/pnas.0730817100
   Kashyap SR, 2009, OBESITY, V17, P1696, DOI 10.1038/oby.2009.89
   KATO T, 1973, J NEUROCHEM, V20, P151, DOI 10.1111/j.1471-4159.1973.tb12112.x
   Kelley DE, 2000, DIABETES, V49, P677, DOI 10.2337/diabetes.49.5.677
   KELLEY DE, 1990, AM J PHYSIOL, V258, pE923, DOI 10.1152/ajpendo.1990.258.6.E923
   KENNEDY ML, 1987, J NUTR, V117, P886, DOI 10.1093/jn/117.5.886
   KILLINGER DW, 1995, J STEROID BIOCHEM, V52, P195, DOI 10.1016/0960-0760(94)00164-H
   Kleessen B, 2001, BRIT J NUTR, V86, P291, DOI 10.1079/BJN2001403
   Klein S, 1996, DIABETES, V45, P984, DOI 10.2337/diabetes.45.7.984
   Kolwankar D, 2007, CLIN GASTROENTEROL H, V5, P388, DOI 10.1016/j.cgh.2006.12.021
   Koonen DPY, 2010, DIABETES, V59, P1366, DOI 10.2337/db09-1142
   Kus V, 2008, AM J PHYSIOL-ENDOC M, V295, pE356, DOI 10.1152/ajpendo.90256.2008
   Lapierre LR, 2007, FUTURE LIPIDOL, V2, P173, DOI 10.2217/17460875.2.2.173
   Lavrovsky Y, 2000, EXP GERONTOL, V35, P521, DOI 10.1016/S0531-5565(00)00118-2
   LAWRENCE JC, 1986, J BIOL CHEM, V261, P669
   Lee MJ, 2008, OBESITY, V16, P1178, DOI 10.1038/oby.2008.207
   Lee P, 2010, AM J PHYSIOL-ENDOC M, V299, pE601, DOI 10.1152/ajpendo.00298.2010
   Leibel RL, 2002, NUTR REV, V60, pS15, DOI 10.1301/002966402320634788
   LEVINE GM, 1982, AM J PHYSIOL, V242, pG455, DOI 10.1152/ajpgi.1982.242.5.G455
   Lewis GF, 2005, CIRC RES, V96, P1221, DOI 10.1161/01.RES.0000170946.56981.5c
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Li ZZ, 2009, J BIOL CHEM, V284, P5637, DOI 10.1074/jbc.M807616200
   Lumeng CN, 2007, DIABETES, V56, P16, DOI 10.2337/db06-1076
   MA SWY, 1989, CAN J PHYSIOL PHARM, V67, P376, DOI 10.1139/y89-061
   MA SWY, 1987, CAN J PHYSIOL PHARM, V65, P1802, DOI 10.1139/y87-281
   MARIN P, 1992, METABOLISM, V41, P1242, DOI 10.1016/0026-0495(92)90016-4
   Markan KR, 2010, MOL CELL ENDOCRINOL, V318, P54, DOI 10.1016/j.mce.2009.08.013
   Martin JF, 2000, J NUTR, V130, P741, DOI 10.1093/jn/130.4.741
   Maury E, 2010, MOL CELL ENDOCRINOL, V314, P1, DOI 10.1016/j.mce.2009.07.031
   McClain DA, 2005, AM J PHYSIOL-ENDOC M, V288, pE973, DOI 10.1152/ajpendo.00549.2004
   MCDANIEL HG, 1975, AM J PHYSIOL, V229, P1569, DOI 10.1152/ajplegacy.1975.229.6.1569
   MCKEE G, 1990, COMP BIOCHEM PHYS A, V96, P485, DOI 10.1016/0300-9629(90)90666-G
   McLaughlin T, 2010, DIABETOLOGIA, V53, P369, DOI 10.1007/s00125-009-1496-3
   Meijer K, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017154
   MILLER BG, 1979, BRIT J NUTR, V42, P185, DOI 10.1079/BJN19790106
   MISBIN RI, 1976, AM J PHYSIOL, V230, P171, DOI 10.1152/ajplegacy.1976.230.1.171
   Mizuno H, 2008, CELLS TISSUES ORGANS, V187, P177, DOI 10.1159/000110805
   Mojiminiyi OA, 2008, NUTR METAB CARDIOVAS, V18, P559, DOI 10.1016/j.numecd.2007.07.007
   MORALES LM, 1994, BIOCHEM BIOPH RES CO, V199, P1151, DOI 10.1006/bbrc.1994.1351
   Mueckler M, 2001, J CLIN INVEST, V107, P1211, DOI 10.1172/JCI13020
   Muñoz S, 2010, DIABETOLOGIA, V53, P2417, DOI 10.1007/s00125-010-1840-7
   Nakagawa T, 2005, NAT CLIN PRACT NEPHR, V1, P80, DOI 10.1038/ncpneph0019
   OCONNELL RC, 1974, J CLIN ENDOCR METAB, V39, P555, DOI 10.1210/jcem-39-3-555
   Oswal A, 2007, OBES REV, V8, P293, DOI 10.1111/j.1467-789X.2007.00378.x
   Oswal A, 2010, OBESITY, V18, P221, DOI 10.1038/oby.2009.228
   Ouchi N, 2007, CLIN CHIM ACTA, V380, P24, DOI 10.1016/j.cca.2007.01.026
   PEASE RJ, 1987, EUR J BIOCHEM, V164, P251, DOI 10.1111/j.1432-1033.1987.tb11018.x
   PECKHAM SC, 1962, J NUTR, V77, P187, DOI 10.1093/jn/77.2.187
   PERKINS MN, 1981, NATURE, V289, P401, DOI 10.1038/289401a0
   Pettinelli P, 2009, BBA-MOL BASIS DIS, V1792, P1080, DOI 10.1016/j.bbadis.2009.08.015
   Pickering C, 2009, PSYCHOPHARMACOLOGY, V204, P431, DOI 10.1007/s00213-009-1474-y
   Pihlajamäki J, 2004, J LIPID RES, V45, P507, DOI 10.1194/jlr.M300368-JLR200
   Poulos SP, 2010, MOL CELL ENDOCRINOL, V323, P20, DOI 10.1016/j.mce.2009.12.011
   Price ER, 2008, J EXP BIOL, V211, P29, DOI 10.1242/jeb.009340
   Puig JG, 2008, CURR OPIN RHEUMATOL, V20, P187, DOI 10.1097/BOR.0b013e3282f4b1ed
   Quinkler M, 2004, J ENDOCRINOL, V183, P331, DOI 10.1677/joe.1.05762
   Qvisth V, 2008, J CLIN ENDOCR METAB, V93, P240, DOI 10.1210/jc.2007-1313
   RAFECAS I, 1995, J CLIN ENDOCR METAB, V80, P693, DOI 10.1210/jc.80.2.693
   Ragheb R, 2009, BIOCHEM BIOPH RES CO, V389, P211, DOI 10.1016/j.bbrc.2009.08.106
   Rajala MW, 2003, ENDOCRINOLOGY, V144, P3765, DOI 10.1210/en.2003-0580
   Ravikumar B, 2005, AM J PHYSIOL-ENDOC M, V288, pE789, DOI 10.1152/ajpendo.00557.2004
   Ravussin E, 2010, CURR DIABETES REP, V10, P90, DOI 10.1007/s11892-010-0092-8
   Remesar X, 2002, INT J OBESITY, V26, P1092, DOI 10.1038/sj.ijo.0802056
   Reusch JEB, 2002, AM J CARDIOL, V90, p19G
   RICHTER EA, 1988, BIOCHEM J, V252, P733, DOI 10.1042/bj2520733
   RICQUIER D, 1986, J BIOL CHEM, V261, P13905
   RIOU JP, 1986, METABOLISM, V35, P608, DOI 10.1016/0026-0495(86)90165-4
   Romero MD, 2007, NUTR METAB, V4, DOI 10.1186/1743-7075-4-26
   ROMIJN JA, 1990, METABOLISM, V39, P525, DOI 10.1016/0026-0495(90)90012-2
   Saad MF, 2004, HYPERTENSION, V43, P1324, DOI 10.1161/01.HYP.0000128019.19363.f9
   Sacks HS, 2007, AM HEART J, V153, P907, DOI 10.1016/j.ahj.2007.03.019
   Saito K, 2006, BBA-MOL CELL BIOL L, V1761, P709, DOI 10.1016/j.bbalip.2006.04.016
   Salmon D M, 1974, Biochem J, V142, P611
   Saltiel AR, 2001, NATURE, V414, P799, DOI 10.1038/414799a
   SAUDEK CD, 1976, AM J MED, V60, P117, DOI 10.1016/0002-9343(76)90540-4
   Scherer PE, 2006, DIABETES, V55, P1537, DOI 10.2337/db06-0263
   SCHMIDTNIELSEN K, 1975, ANIMAL PHYSL, P208
   SCHUTZ Y, 1985, INT J OBESITY, V9, P111
   Schwarz JM, 2003, AM J CLIN NUTR, V77, P43, DOI 10.1093/ajcn/77.1.43
   Shen W, 2009, NUTR METAB, V6, DOI 10.1186/1743-7075-6-17
   Silvestri E, 2005, ACTA PHYSIOL SCAND, V184, P265, DOI 10.1111/j.1365-201X.2005.01463.x
   Simonen P, 2011, J HEPATOL, V54, P153, DOI 10.1016/j.jhep.2010.05.037
   Skilton MR, 2008, BRIT J NUTR, V100, P400, DOI 10.1017/S0007114507898655
   Sorensen LB, 2003, INT J OBESITY, V27, P1152, DOI 10.1038/sj.ijo.0802391
   Sorisky A, 2000, INT J OBESITY, V24, pS3, DOI 10.1038/sj.ijo.0801491
   Spiroglou SG, 2010, J ATHEROSCLER THROMB, V17, P115
   Stich V, 2000, J APPL PHYSIOL, V88, P1277, DOI 10.1152/jappl.2000.88.4.1277
   Stienstra R, 2010, HEPATOLOGY, V51, P511, DOI 10.1002/hep.23337
   STROMBLAD G, 1986, METABOLISM, V35, P323, DOI 10.1016/0026-0495(86)90148-4
   Subramanian S, 2008, ARTERIOSCL THROM VAS, V28, P685, DOI 10.1161/ATVBAHA.107.157685
   TAYLOR SI, 1974, ARCH BIOCHEM BIOPHYS, V164, P12, DOI 10.1016/0003-9861(74)90002-2
   Tilg H, 2010, J CLIN GASTROENTEROL, V44, pS16, DOI 10.1097/MCG.0b013e3181dd8b64
   To WWK, 2009, AUST NZ J OBSTET GYN, V49, P34, DOI 10.1111/j.1479-828X.2008.00933.x
   Trayhurn P, 2004, BRIT J NUTR, V92, P347, DOI 10.1079/BJN20041213
   Ulrich P, 2001, RECENT PROG HORM RES, V56, P1, DOI 10.1210/rp.56.1.1
   Wang D, 2006, ENDOCRINOLOGY, V147, P943, DOI 10.1210/en.2005-0570
   Wang Q, 1997, DIABETES, V46, P335, DOI 10.2337/diabetes.46.3.335
   Watve MG, 2007, BMC EVOL BIOL, V7, DOI 10.1186/1471-2148-7-61
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Wood IS, 2007, BIOCHEM BIOPH RES CO, V361, P468, DOI 10.1016/j.bbrc.2007.07.032
   Woods SC, 2006, PHILOS T R SOC B, V361, P1219, DOI 10.1098/rstb.2006.1858
   Yang WS, 2001, J CLIN ENDOCR METAB, V86, P3815, DOI 10.1210/jc.86.8.3815
   Yanoff LB, 2007, INT J OBESITY, V31, P1412, DOI 10.1038/sj.ijo.0803625
   Yanovski S, 2003, J NUTR, V133, p835S, DOI 10.1093/jn/133.3.835S
   Yea K, 2009, J BIOL CHEM, V284, P33833, DOI 10.1074/jbc.M109.024869
   YOUNG P, 1985, BIOCHEM BIOPH RES CO, V130, P241, DOI 10.1016/0006-291X(85)90408-5
   ZHANG YY, 1994, NATURE, V372, P425, DOI 10.1038/372425a0
   Zheng H, 2009, INT J OBESITY, V33, pS8, DOI 10.1038/ijo.2009.65
   Zuk PA, 2002, MOL BIOL CELL, V13, P4279, DOI 10.1091/mbc.E02-02-0105
   ZURLO F, 1990, J CLIN INVEST, V86, P1423, DOI 10.1172/JCI114857
NR 197
TC 17
Z9 18
U1 0
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD OCT 26
PY 2011
VL 8
AR 74
DI 10.1186/1743-7075-8-74
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 853DI
UT WOS:000297406000001
PM 22029632
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tefagh, G
   Payab, M
   Qorbani, M
   Sharifi, F
   Sharifi, Y
   Shirvani, MSE
   Pourghazi, F
   Atlasi, R
   Shadman, Z
   Rezaei, N
   Mohammadi-Vajari, E
   Larijani, B
   Ebrahimpur, M
AF Tefagh, Ghazale
   Payab, Moloud
   Qorbani, Mostafa
   Sharifi, Farshad
   Sharifi, Yasaman
   Shirvani, Mahbubeh Sadat Ebrahimnegad
   Pourghazi, Farzad
   Atlasi, Rasha
   Shadman, Zhaleh
   Rezaei, Nafiseh
   Mohammadi-Vajari, Erfan
   Larijani, Bagher
   Ebrahimpur, Mahbube
TI Effect of vitamin E supplementation on cardiometabolic risk factors,
   inflammatory and oxidative markers and hormonal functions in PCOS
   (polycystic ovary syndrome): a systematic review and meta-analysis
SO SCIENTIFIC REPORTS
LA English
DT Article
ID E CO-SUPPLEMENTATION; INSULIN-RESISTANCE; GENE-EXPRESSION;
   OMEGA-3-FATTY-ACIDS; PATHOPHYSIOLOGY; DYSLIPIDEMIA; PARAMETERS; OMEGA-3;
   STRESS; LIPIDS
AB Polycystic ovary syndrome (PCOS) is a common endocrinopathy among reproductive-age women. Various therapeutical approaches are currently used to manage or control symptoms associated with PCOS. This systematic review intended to assess the effects of Vit E supplementation on cardiometabolic risk factors, inflammatory and oxidative markers, and hormonal functions in PCOS women based on the clinical trial's results. The databases including PubMed, Scopus, Cochrane, Web of Science, and Embase were used to find all relevant studies. The authors reviewed all relevant clinical trials via systematic evaluation of abstracts and titles. Searches were conducted on August 1, 2020. After the initial search and reading of the article's title and abstract, 353 articles were reviewed; finally, 12 articles met the inclusion criteria. Vitamin E supplementation improves lipid profile, decreases insulin and HOMA-IR levels. Furthermore, while Vitamin E supplementation decreases LH and testosterone concentrations, it increases FSH and progestrone concentrations. The following meta-analysis showed that vitamin E supplementation made statistically significant improvements in triglyceride (TG) and low-density lipoproteins (LDL) levels, meanwhile, pooled mean difference for waist circumference (WC) and HOMA-IR were also statistically significant. Supplementary regimens containing vitamin E can positively affect metabolic and hormonal parameters in women with PCOS.
C1 [Tefagh, Ghazale] Univ Tehran Med Sci, Adv Diagnost & Intervent Radiol Res Ctr, Imam Khomeini Hosp Complex, Tehran, Iran.
   [Payab, Moloud; Sharifi, Yasaman; Pourghazi, Farzad; Larijani, Bagher] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, First Floor,10 Jalal Al Ahmad St,North Kargar Ave, Tehran 1411713137, Iran.
   [Qorbani, Mostafa] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.
   [Sharifi, Farshad; Shadman, Zhaleh; Ebrahimpur, Mahbube] Univ Tehran Med Sci, Elderly Hlth Res Ctr, Endocrinol & Metab Populat Sci Inst, First Floor,10 Jalal Al Ahmad St,North Kargar Ave, Tehran 1411713137, Iran.
   [Shirvani, Mahbubeh Sadat Ebrahimnegad] Iran Univ Med Sci, Sch Med, Dept Emergency Med, Tehran, Iran.
   [Atlasi, Rasha] Univ Tehran Med Sci, Evidence Based Practice Res Ctr, Endocrinol & Metab Res Inst, Tehran, Iran.
   [Rezaei, Nafiseh] Univ Tehran Med Sci, Paramed Fac, Dept Med Lib & Informat Sci, Tehran, Iran.
   [Rezaei, Nafiseh] Hamadan Univ Med Sci, Paramed Fac, Dept Med Lib & Informat Sci, Hamadan, Hamadan, Iran.
   [Mohammadi-Vajari, Erfan] Guilan Univ Med Sci, Sch Med, Rasht, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Alborz University of Medical Sciences; Tehran University of
   Medical Sciences; Iran University of Medical Sciences; Tehran University
   of Medical Sciences; Tehran University of Medical Sciences; Hamadan
   University of Medical Sciences; Guilan University of Medical Sciences
RP Payab, M (corresponding author), Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, First Floor,10 Jalal Al Ahmad St,North Kargar Ave, Tehran 1411713137, Iran.; Ebrahimpur, M (corresponding author), Univ Tehran Med Sci, Elderly Hlth Res Ctr, Endocrinol & Metab Populat Sci Inst, First Floor,10 Jalal Al Ahmad St,North Kargar Ave, Tehran 1411713137, Iran.
EM moloudpayab@gmail.com; m-ebrahimpur@tums.ac.ir
RI Pourghazi, Farzad/KYD-7103-2024; Qorbani, Mostafa/M-8171-2017; Sharifi,
   Yasaman/AAU-5007-2021; Atlasi, Rasha/HKW-2346-2023; Rezaei,
   Nafiseh/JDM-8067-2023; Mohammadi-Vajari, Erfan/AAW-6515-2021; larijani,
   Bagher/ABE-3315-2020
OI Mohammadi-Vajari, Erfan/0000-0002-9849-3485; Pourghazi,
   Farzad/0000-0002-9684-1466; Larijani, Bagher/0000-0001-5386-7597;
   Rezaei, Nafiseh/0000-0002-5763-4974; Sharifi,
   Yasaman/0000-0001-5563-6311; Tefagh, Ghazale/0000-0002-1119-6438
FU Tehran University of Medical Sciences (Endocrinology and Metabolism
   Research Center)
FX Implementation of this study was sponsored by the Tehran University of
   Medical Sciences (Endocrinology and Metabolism Research Center).
CR Anagnostis P, 2018, METABOLISM, V86, P33, DOI 10.1016/j.metabol.2017.09.016
   Asbaghi O, 2019, DIAB MET SYND CLIN R, V13, P2525, DOI 10.1016/j.dsx.2019.07.001
   Azziz R, 2004, J CLIN ENDOCR METAB, V89, P2745, DOI 10.1210/jc.2003-032046
   Boots CE, 2015, SEMIN REPROD MED, V33, P270, DOI 10.1055/s-0035-1554928
   Chakraborty P, 2013, BIOL TRACE ELEM RES, V152, P9, DOI 10.1007/s12011-012-9592-5
   Chang Wenlu, 2014, Wei Sheng Yan Jiu, V43, P713
   Chen JJ, 2020, BMC COMPLEMENT MED, V20, DOI [10.1186/s12870-020-02554-6, 10.1186/s12906-020-2872-2]
   Diamanti-Kandarakis E, 2007, TRENDS ENDOCRIN MET, V18, P280, DOI 10.1016/j.tem.2007.07.004
   Dou M, 2009, NUTR RES, V29, P519, DOI 10.1016/j.nutres.2009.07.001
   Ebrahimi FA, 2017, EXP CLIN ENDOCR DIAB, V125, P353, DOI 10.1055/s-0042-117773
   Guyatt GH, 2008, BRIT MED J, V336, P924, DOI 10.1136/bmj.39489.470347.AD
   Hager M, 2019, ARCH GYNECOL OBSTET, V300, P455, DOI 10.1007/s00404-019-05194-w
   Izadi A, 2019, ARCH MED RES, V50, P1, DOI 10.1016/j.arcmed.2019.04.004
   Izadi A, 2019, J CLIN ENDOCR METAB, V104, P319, DOI 10.1210/jc.2018-01221
   Jamil AS, 2015, REPROD HEALTH, V12, DOI 10.1186/1742-4755-12-7
   Jamilian M, 2019, HORM METAB RES, V51, P100, DOI 10.1055/a-0749-6431
   Jamilian M, 2018, J AFFECT DISORDERS, V229, P41, DOI 10.1016/j.jad.2017.12.049
   Macut D, 2013, FRONT HORM RES, V40, P51, DOI 10.1159/000341683
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Niki E, 2014, FREE RADICAL BIO MED, V66, P3, DOI 10.1016/j.freeradbiomed.2013.03.022
   Ovalle F, 2002, FERTIL STERIL, V77, P1095, DOI 10.1016/S0015-0282(02)03111-4
   Panti A. A., 2018, International Journal of Reproduction, Contraception, Obstetrics and Gynecology, V7, P1667, DOI [10.18203/2320-1770.ijrcog20181892, DOI 10.18203/2320-1770.IJRCOG20181892]
   Rahmani E, 2017, MOL CELL ENDOCRINOL, V439, P247, DOI 10.1016/j.mce.2016.09.008
   Sadeghi F, 2020, INT J VITAM NUTR RES, V90, P477, DOI 10.1024/0300-9831/a000588
   Schunemann H BJ., 2013, GRADE Handbook
   Sepidarkish M, 2020, CLIN NUTR, V39, P1019, DOI 10.1016/j.clnu.2019.05.004
   Shokrpour M, 2019, BIOL TRACE ELEM RES, V191, P54, DOI 10.1007/s12011-018-1602-9
   Shorakae S, 2015, SEMIN REPROD MED, V33, P257, DOI 10.1055/s-0035-1556568
   Talari Hamid Reza, 2018, Oman Med J, V33, P473, DOI 10.5001/omj.2018.88
   Teede HJ, 2011, MED J AUSTRALIA, V195, pS69, DOI 10.5694/mja11.10915
   Tsilchorozidou T, 2004, CLIN ENDOCRINOL, V60, P1, DOI 10.1046/j.1365-2265.2003.01842.x
   Zhang Dan, 2008, Sichuan Da Xue Xue Bao Yi Xue Ban, V39, P421
NR 32
TC 20
Z9 20
U1 0
U2 9
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 6
PY 2022
VL 12
IS 1
AR 5770
DI 10.1038/s41598-022-09082-3
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 0J5SN
UT WOS:000780164200015
PM 35388031
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Oluwagbemigun, K
   Anesi, A
   Ulaszewska, M
   Clarke, G
   Alexy, U
   Schmid, M
   Roden, M
   Herder, C
   Mattivi, F
   Nöthlings, U
AF Oluwagbemigun, Kolade
   Anesi, Andrea
   Ulaszewska, Maria
   Clarke, Gerard
   Alexy, Ute
   Schmid, Matthias
   Roden, Michael
   Herder, Christian
   Mattivi, Fulvio
   Noethlings, Ute
TI Longitudinal relationship of amino acids and indole metabolites with
   long-term body mass index and cardiometabolic risk markers in young
   individuals
SO SCIENTIFIC REPORTS
LA English
DT Article
ID INSULIN-RESISTANCE; BRANCHED-CHAIN; HUMAN GUT; METABOLOMIC PROFILES;
   KYNURENINE PATHWAY; CHILDHOOD OBESITY; OXIDATIVE STRESS; TRYPTOPHAN;
   BIOMARKERS; PLASMA
AB Amino acid metabolites in biofluids are associated with high body mass index (BMI) and cardiometabolic abnormalities. However, prospective investigations regarding these associations are few, particularly among young individuals. Moreover, little is presently known about the impact of long-term high BMI. Using data from the DOrtmund Nutritional and Anthropometric Longitudinally Designed study (111 males and 107 females), we prospectively investigated relations between repeatedly measured urinary levels of 33 metabolites and (1) previously identified long-term BMI trajectory groups from childhood into late adolescence and (2) cardiometabolic risk markers in late adolescence-young adulthood, in sex-specific linear mixed regression models. Males with long-term overweight had lower indole-3-acetic acid when compared to others. Further, methionine, isoleucine, tryptophan, xanthurenic acid, and indole-3-carboxaldehyde were negatively associated with C-reactive protein (CRP), but 5-hydroxyindole-3-acetic acid was positively associated with CRP. No associations were observed in females. Long-term overweight from childhood into late adolescence is associated with decreased urinary levels of gut bacteria-derived indole-3-acetic acid, and several urinary amino acids, including gut bacteria-derived indole-3-carboxaldehyde are associated with elevated CRP later on in life. Taken together, our data suggest that indole metabolites, and their gut bacteria producers play potentially important roles in overweight-related inflammation.
C1 [Oluwagbemigun, Kolade; Alexy, Ute; Noethlings, Ute] Univ Bonn, Dept Nutr & Food Sci, Nutr Epidemiol, Bonn, Germany.
   [Anesi, Andrea; Ulaszewska, Maria; Mattivi, Fulvio] Fdn Edmund Mach FEM, Dept Food Qual & Nutr, Res & Innovat Ctr, San Michele All Adige, Italy.
   [Clarke, Gerard] Univ Coll Cork, APC Microbiome Ireland, Cork, Ireland.
   [Clarke, Gerard] Univ Coll Cork, INFANT Res Ctr, Cork, Ireland.
   [Clarke, Gerard] Univ Coll Cork, Dept Psychiat & Neurobehav Sci, Cork, Ireland.
   [Schmid, Matthias] Univ Bonn, Univ Hosp Bonn, Dept Med Biometry Informat & Epidemiol, Bonn, Germany.
   [Roden, Michael; Herder, Christian] Heinrich Heine Univ Dusseldorf, Fac Med, Div Endocrinol & Diabetol, Dusseldorf, Germany.
   [Herder, Christian] Heinrich Heine Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Ctr, Inst Clin Diabetol, Dusseldorf, Germany.
   [Herder, Christian] German Ctr Diabet Res DZD, Munich, Germany.
   [Mattivi, Fulvio] Univ Trento, Dept Phys, San Michele All Adige, Italy.
C3 University of Bonn; Fondazione Edmund Mach; University College Cork;
   University College Cork; University College Cork; University of Bonn;
   Heinrich Heine University Dusseldorf; Heinrich Heine University
   Dusseldorf; Leibniz Association; Deutsches Diabetes-Zentrum (DDZ);
   German Center for Diabetes Research (DZD); University of Trento
RP Oluwagbemigun, K (corresponding author), Univ Bonn, Dept Nutr & Food Sci, Nutr Epidemiol, Bonn, Germany.
EM koluwagb@uni-bonn.de
RI Nöthlings, Ute/B-2713-2010; Roden, Michael/AAD-3843-2019; Oluwagbemigun,
   Kolade/AAV-2041-2021; Ulaszewska, Maria/AAI-2595-2019; Anesi,
   Andrea/ACJ-6729-2022; Alexy, Ute/E-8589-2018; Clarke,
   Gerard/Y-2551-2019; MATTIVI, FULVIO/B-7645-2011
OI MATTIVI, FULVIO/0000-0003-4935-5876; Ulaszewska,
   Maria/0000-0002-0929-2359; Anesi, Andrea/0000-0002-9334-2610;
   Oluwagbemigun, Kolade/0000-0002-9454-5970; Alexy,
   Ute/0000-0002-1488-5175; Nothlings, Ute/0000-0002-5789-2252; Schmid,
   Matthias/0000-0002-0788-0317; Clarke, Gerard/0000-0001-9771-3979
FU project "Metabolic HEALTH through nutrition, microbiota and tryptophan
   bioMARKers" of the EU Joint Programming Initiative "A Healthy Diet for a
   Healthy Life" (ERA HDHL -HEALTHMARK); Federal Ministry of Education and
   Research (BMBF), Germany [01EA1705A]; Science Foundation Ireland,
   Ireland [16/ERA-HDHL/3362]; Ministry of Education, University and
   Research (MIUR), Italy [CUP D43C17000100006]; Ministry of Science and
   Research of North Rhine Westphalia, Germany; German Research
   Association; German Federal Ministry of Health; Ministry of Culture and
   Science of the State North Rhine-Westphalia; BMBF; "DietBody-Brain
   (DietBB)" Competence Cluster in Nutrition Research - BMBF [FKZ:
   01EA1809A]; Science Foundation Ireland (SFI) [16/ERA-HDHL/3362] Funding
   Source: Science Foundation Ireland (SFI)
FX The authors would like to appreciate the DONALD study participants and
   their families for their interest, time, commitment, and provision of
   their data. We also acknowledge the support of the staffs at the study
   centre for data collection and processing of urine and blood samples. We
   also thank Stefan Benda for his support in formatting the figures. This
   study was financially supported by the project "Metabolic HEALTH through
   nutrition, microbiota and tryptophan bioMARKers in the frame of the EU
   Joint Programming Initiative "A Healthy Diet for a Healthy Life" (ERA
   HDHL -HEALTHMARK) and the respective national funding organizations: the
   Federal Ministry of Education and Research (BMBF), Germany (grant
   number: 01EA1705A), Science Foundation Ireland, Ireland (grant number,
   16/ERA-HDHL/3362), and the Ministry of Education, University and
   Research (MIUR), Italy (CUP D43C17000100006). The DONALD study is
   supported by the Ministry of Science and Research of North Rhine
   Westphalia, Germany. Biomarker measurements were funded by the German
   Research Association. The German Diabetes Center is funded by the German
   Federal Ministry of Health and the Ministry of Culture and Science of
   the State North Rhine-Westphalia. This study was also supported in part
   by a grant from the BMBF to the German Center for Diabetes Research (DZD
   e.V.). This study was also supported by the "DietBody-Brain (DietBB)"
   Competence Cluster in Nutrition Research funded by the BMBF, FKZ:
   01EA1809A. The funding sources had no influence on study design; in the
   collection, analysis, and interpretation of data; in the writing of the
   report; and in the decision to submit the paper for publication.
CR Adams SH, 2011, ADV NUTR, V2, P445, DOI 10.3945/an.111.000737
   Afarideh M, 2015, ENDOCR PRACT, V21, P711, DOI 10.4158/EP14442.OR
   Anesi A, 2019, METABOLITES, V9, DOI 10.3390/metabo9110261
   [Anonymous], 2012, FOOD NUTR SCI, V3, P548, DOI [10.4236/fns.2012.34077, DOI 10.4236/FNS.2012.34077]
   Barat P, 2016, PSYCHONEUROENDOCRINO, V74, P158, DOI 10.1016/j.psyneuen.2016.09.002
   Butte NF, 2015, AM J CLIN NUTR, V102, P256, DOI 10.3945/ajcn.115.111872
   Buyken AE, 2012, BUNDESGESUNDHEITSBLA, V55, P875, DOI 10.1007/s00103-012-1503-6
   Chen GC, 2018, BRIT J NUTR, V119, P1057, DOI [10.1017/S0007114518000119, 10.1017/s0007114518000119]
   Chung ST, 2018, ANN NY ACAD SCI, V1411, P166, DOI 10.1111/nyas.13602
   Comitato R, 2015, CRIT REV FOOD SCI, V55, P227, DOI 10.1080/10408398.2011.651177
   Corcuff JB, 2017, ENDOCR CONNECT, V6, pR87, DOI 10.1530/EC-17-0071
   DeBoer MD, 2013, NUTRITION, V29, P379, DOI 10.1016/j.nut.2012.07.003
   Descamps HC, 2019, EBIOMEDICINE, V44, P747, DOI 10.1016/j.ebiom.2019.05.063
   Diederichs T, 2017, NUTRIENTS, V9, DOI 10.3390/nu9060591
   Dou L, 2015, J AM SOC NEPHROL, V26, P876, DOI 10.1681/ASN.2013121283
   Ellulu MS, 2017, ARCH MED SCI, V13, P851, DOI 10.5114/aoms.2016.58928
   Elshorbagy AK, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0044166
   Farook VS, 2015, PEDIATR OBES, V10, P320, DOI 10.1111/ijpo.270
   Favennec M, 2015, OBESITY, V23, P2066, DOI 10.1002/oby.21199
   Ferreira DLS, 2017, PLOS MED, V14, DOI 10.1371/journal.pmed.1002376
   Galgani J.E., 2016, Metabolic Syndrome, P327, DOI DOI 10.1007/978-3-319-11251-0_21
   Gancheva S, 2018, PHYSIOL REV, V98, P1371, DOI 10.1152/physrev.00015.2017
   Geserick M, 2018, NEW ENGL J MED, V379, P1303, DOI 10.1056/NEJMoa1803527
   Goletzke J, 2014, J NUTR, V144, P1586, DOI 10.3945/jn.114.193391
   Güngör NK, 2014, J CLIN RES PEDIATR E, V6, P129, DOI [10.4274/jcrpe.1471, 10.4274/Jcrpe.1471]
   Herman MA, 2010, J BIOL CHEM, V285, P11348, DOI 10.1074/jbc.M109.075184
   Huque MH, 2018, BMC MED RES METHODOL, V18, DOI 10.1186/s12874-018-0615-6
   Jaglin M, 2018, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00216
   Kennedy PJ, 2017, NEUROPHARMACOLOGY, V112, P399, DOI 10.1016/j.neuropharm.2016.07.002
   Keszthelyi D, 2009, NEUROGASTROENT MOTIL, V21, P1239, DOI 10.1111/j.1365-2982.2009.01370.x
   Kosek MN, 2016, AM J TROP MED HYG, V95, P928, DOI 10.4269/ajtmh.16-0037
   Lee A, 2015, OBES RES CLIN PRACT, V9, P336, DOI 10.1016/j.orcp.2014.10.220
   Liu Y, 2018, ALLERGY ASTHMA IMMUN, V10, P628, DOI 10.4168/aair.2018.10.6.628
   Maes M, 2007, NEUROENDOCRINOL LETT, V28, P826
   Mangge H, 2014, OBESITY, V22, P195, DOI 10.1002/oby.20491
   Marcobal A, 2013, ISME J, V7, P1933, DOI 10.1038/ismej.2013.89
   Martínez Y, 2017, AMINO ACIDS, V49, P2091, DOI 10.1007/s00726-017-2494-2
   McCormack SE, 2013, PEDIATR OBES, V8, P52, DOI 10.1111/j.2047-6310.2012.00087.x
   Mellor AL, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01360
   Mihalik SJ, 2012, DIABETES CARE, V35, P605, DOI [10.2337/DC11-1577, 10.2337/dc11-1577]
   Morris C, 2012, P NUTR SOC, V71, P634, DOI 10.1017/S0029665112000699
   Newbern D, 2014, J CLIN ENDOCR METAB, V99, P4730, DOI 10.1210/jc.2014-2080
   Newgard CB, 2017, CELL METAB, V25, P43, DOI 10.1016/j.cmet.2016.09.018
   Nikolaus S, 2017, GASTROENTEROLOGY, V153, P1504, DOI 10.1053/j.gastro.2017.08.028
   Nocito A, 2007, GASTROENTEROLOGY, V133, P608, DOI 10.1053/j.gastro.2007.05.019
   Ocampo JR, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/646909
   Oluwagbemigun K, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0813-5
   Osadchiy V, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0201772
   Perng W, 2018, OBESITY, V26, P916, DOI 10.1002/oby.22164
   Perng W, 2014, OBESITY, V22, P2570, DOI 10.1002/oby.20901
   Pitchika A, 2018, DIABETOLOGIA, V61, P2319, DOI 10.1007/s00125-018-4688-x
   POLBERGER SKT, 1990, PEDIATRICS, V86, P909
   Popa M, 1989, Endocrinologie, V27, P29
   Remer T, 2002, AM J CLIN NUTR, V75, P561, DOI 10.1093/ajcn/75.3.561
   Roager HM, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05470-4
   Russell WR, 2013, MOL NUTR FOOD RES, V57, P523, DOI 10.1002/mnfr.201200594
   SAXENA R N, 1984, Indian Journal of Physiology and Pharmacology, V28, P299
   Shoaie S, 2015, CELL METAB, V22, P320, DOI 10.1016/j.cmet.2015.07.001
   Swimm A, 2018, BLOOD, V132, P2506, DOI 10.1182/blood-2018-03-838193
   Takada A, 2019, Bioactive food as dietary interventions for diabetes, P265
   Twisk J, 2013, J CLIN EPIDEMIOL, V66, P1022, DOI 10.1016/j.jclinepi.2013.03.017
   Virtue AT, 2019, SCI TRANSL MED, V11, DOI 10.1126/scitranslmed.aav1892
   Waclawiková B, 2018, PHARMACEUTICALS-BASE, V11, DOI 10.3390/ph11030063
   Wang YF, 2016, CIRC RES, V119, P222, DOI 10.1161/CIRCRESAHA.116.308559
   Weischendorff S, 2019, BIOL BLOOD MARROW TR, V25, P1432, DOI 10.1016/j.bbmt.2019.03.018
   Wikoff WR, 2009, P NATL ACAD SCI USA, V106, P3698, DOI 10.1073/pnas.0812874106
   World Health Organization, 2016, Report of the commission on ending childhood obesity
   Würtz P, 2013, DIABETES CARE, V36, P648, DOI 10.2337/dc12-0895
   Yamakado M, 2015, SCI REP-UK, V5, DOI 10.1038/srep11918
   Zhang SH, 2017, J ANIM SCI BIOTECHNO, V8, DOI 10.1186/s40104-016-0139-z
   Zhao X, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/8160545
   Zuo H, 2016, AM J EPIDEMIOL, V183, P249, DOI 10.1093/aje/kwv242
NR 72
TC 16
Z9 17
U1 0
U2 7
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 14
PY 2020
VL 10
IS 1
AR 6399
DI 10.1038/s41598-020-63313-z
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA ND8OX
UT WOS:000562163200010
PM 32286421
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kim, HY
   Okubo, T
   Juneja, LR
   Yokozawa, T
AF Kim, Hyun Young
   Okubo, Tsutomu
   Juneja, Lekh Raj
   Yokozawa, Takako
TI The protective role of amla (Emblica officinalis Gaertn.) against
   fructose-induced metabolic syndrome in a rat model
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Amla; High-fructose diet; Metabolic syndrome; Sterol regulatory
   element-binding protein-1; NF-kappa B
ID FACTOR-KAPPA-B; RECEPTOR-ALPHA EXPRESSION; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; ANTIOXIDANT ACTIVITY; CARDIAC-HYPERTROPHY; PHYLLANTHUS-EMBLICA;
   LIPID-PEROXIDATION; DIABETES-MELLITUS; ENDOTHELIAL-CELLS
AB We investigated the effects of amla (Emblica officinalis Gaertn.) on fructose-induced metabolic syndrome using a rat model. Male Wistar rats were fed a high-fructose (65 %) diet or standard chow for I week, and treated with an ethyl acetate (EtOAc) extract of amla, a polyphenol-rich fraction, at 10 or 20 mg/kg body weight per d, or vehicle, for 2 weeks. Serum glucose, TAG, total cholesterol and blood pressure levels of the high-fructose diet-fed rats were increased compared with those of the normal rats (P<0.001). However, the EtOAc extract of amla ameliorated the high fructose-induced metabolic syndrome, including hypertriacylglycerolaemia and hypercholesterolaemia. Also, the elevated levels of hepatic TAG and total cholesterol in rats given the high-fructose diet were significantly reduced by 33-8 and 24-6 %, respectively (P<0.001), on the administration of the EtOAc extract of amla at the dose of 20 mg/kg with the regulation of sterol regulatory element-binding protein (SREBP)-I expression. The protein levels of PPAR alpha. and SREBP-2 were not affected by the feeding of the high-fructose diet or EtOAc extract of amla. In addition, oral administration of the amla extract at the dose of 20 mg/kg significantly inhibited the increased serum and hepatic mitochondrial thiobarbituric acid-reactive substance levels (21.1 and 43.1%, respectively; P<0.001). Furthermore, the amla extract inhibited the increase of cyclo-oxygenase-2 with the regulation of NF-kappa B and bcl-2 proteins in the liver, while the elevated expression level of bax was significantly decreased by 8.5 and 10.2% at the doses of 10 and 20mg/kg body weight per d, respectively. These findings suggest that fructose-induced metabolic syndrome is attenuated by the polyphenol-rich fraction of amla.
C1 [Kim, Hyun Young; Yokozawa, Takako] Toyama Univ, Inst Nat Med, Toyama 9300194, Japan.
   [Kim, Hyun Young] Jinju Natl Univ, Dept Food Sci, Jinju 660758, South Korea.
   [Okubo, Tsutomu; Juneja, Lekh Raj] Taiyo Kagaku Co Ltd, Bionutr Div, Yokaichi 5100844, Japan.
C3 University of Toyama; TAIYO KAGAKU CO., LTD.
RP Yokozawa, T (corresponding author), Toyama Univ, Inst Nat Med, 2630 Sugitani, Toyama 9300194, Japan.
EM yokozawa@inm.u-toyama.ac.jp
FU Ministry of Education, Culture, Sports, Science, and Technology, Japan
   [19500661]; Grants-in-Aid for Scientific Research [19500661] Funding
   Source: KAKEN
FX The present study was supported in part by Grants-in-Aid (C) from the
   Ministry of Education, Culture, Sports, Science, and Technology, Japan
   (no. 19500661 to T. Y.).
CR Ackerman Z, 2005, HYPERTENSION, V45, P1012, DOI 10.1161/01.HYP.0000164570.20420.67
   Al-Awwadi NA, 2004, J AGR FOOD CHEM, V52, P5593, DOI 10.1021/jf049295g
   Al-Awwadi NA, 2005, J AGR FOOD CHEM, V53, P151, DOI 10.1021/jf048919f
   Aljada A, 2001, J CLIN ENDOCR METAB, V86, P3250, DOI 10.1210/jc.86.7.3250
   Anila L, 2003, FOOD CHEM, V83, P569, DOI 10.1016/S0308-8146(03)00155-9
   Anila L, 2002, J ETHNOPHARMACOL, V79, P81, DOI 10.1016/S0378-8741(01)00361-0
   [Anonymous], 1996, GUID CAR US LAB AN
   Aoyama T, 1998, J BIOL CHEM, V273, P5678, DOI 10.1074/jbc.273.10.5678
   ASMAWI MZ, 1993, J PHARM PHARMACOL, V45, P581, DOI 10.1111/j.2042-7158.1993.tb05605.x
   Baldwin AS, 2001, J CLIN INVEST, V107, P3, DOI 10.1172/JCI11891
   Bandyopadhyay SK, 2000, J ETHNOPHARMACOL, V70, P171, DOI 10.1016/S0378-8741(99)00146-4
   Barzilay JI, 2001, DIABETES, V50, P2384, DOI 10.2337/diabetes.50.10.2384
   Basciano Heather, 2005, Nutr Metab (Lond), V2, P5, DOI 10.1186/1743-7075-2-5
   Bhattacharya Arunabh, 1999, Indian Journal of Experimental Biology, V37, P676
   Browning JD, 2004, J CLIN INVEST, V114, P147, DOI 10.1172/JCI200422422
   Buege J A, 1978, Methods Enzymol, V52, P302
   Catena C, 2003, AM J HYPERTENS, V16, P973, DOI 10.1016/S0895-7061(03)01002-1
   Chung HY, 2002, MICROSC RES TECHNIQ, V59, P264, DOI 10.1002/jemt.10203
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   Delbosc S, 2005, ATHEROSCLEROSIS, V179, P43, DOI 10.1016/j.atherosclerosis.2004.10.018
   DEOKAR AB, 1998, 125 MED PLANTS GROWN, P48
   Dichtl W, 1999, CIRC RES, V84, P1085, DOI 10.1161/01.RES.84.9.1085
   Dimo T, 2001, PHYTOMEDICINE, V8, P101, DOI 10.1078/0944-7113-00014
   Elliott SS, 2002, AM J CLIN NUTR, V76, P911, DOI 10.1093/ajcn/76.5.911
   ELMEKKAWY S, 1995, CHEM PHARM BULL, V43, P641, DOI 10.1248/cpb.43.641
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   Fried SK, 2003, AM J CLIN NUTR, V78, p873S, DOI 10.1093/ajcn/78.4.873S
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   GERRITS PM, 1993, AM J CLIN NUTR, V58, P796
   Ghanim H, 2001, J CLIN ENDOCR METAB, V86, P1306, DOI 10.1210/jc.86.3.1306
   Ginsberg HN, 2002, CIRCULATION, V106, P2137, DOI 10.1161/01.CIR.0000035280.64322.31
   HALLFRISCH J, 1983, AM J CLIN NUTR, V37, P740, DOI 10.1093/ajcn/37.5.740
   HALLFRISCH J, 1990, FASEB J, V4, P2652, DOI 10.1096/fasebj.4.9.2189777
   HAVEL RJ, 1955, J CLIN INVEST, V34, P1345, DOI 10.1172/JCI103182
   HIGLEY NA, 1991, FOOD TECHNOL-CHICAGO, V45, P118
   HWANG IS, 1987, HYPERTENSION, V10, P512, DOI 10.1161/01.HYP.10.5.512
   ITZHAKI RF, 1964, ANAL BIOCHEM, V9, P401, DOI 10.1016/0003-2697(64)90200-3
   Johnson D., 1967, Methods Enzymol., V10, P94, DOI DOI 10.1016/0076-6879(67)10018-9
   Jose JK, 2001, J ETHNOPHARMACOL, V75, P65, DOI 10.1016/S0378-8741(00)00378-0
   Jose JK, 1995, J CLIN BIOCHEM NUTR, V19, P63, DOI 10.3164/jcbn.19.63
   JUNG K, 1985, FEBS LETT, V183, P167, DOI 10.1016/0014-5793(85)80977-7
   Kang DG, 2004, BIOL PHARM BULL, V27, P1779, DOI 10.1248/bpb.27.1779
   Kelley GL, 2004, ENDOCRINOLOGY, V145, P548, DOI 10.1210/en.2003-1167
   Kersten S, 2000, NATURE, V405, P421, DOI 10.1038/35013000
   Kim HJ, 2005, J NUTR SCI VITAMINOL, V51, P413, DOI 10.3177/jnsv.51.413
   LAEMMLI UK, 1970, NATURE, V227, P680, DOI 10.1038/227680a0
   Leone TC, 1999, P NATL ACAD SCI USA, V96, P7473, DOI 10.1073/pnas.96.13.7473
   Levi B, 1998, J NUTR, V128, P1442, DOI 10.1093/jn/128.9.1442
   Li QT, 2002, NAT REV IMMUNOL, V2, P725, DOI 10.1038/nri910
   MCFARLAND KF, 1979, DIABETES, V28, P1011, DOI 10.2337/diabetes.28.11.1011
   Miatello R, 2005, AM J HYPERTENS, V18, P864, DOI 10.1016/j.amjhyper.2004.12.012
   Miyazaki M, 2004, J BIOL CHEM, V279, P25164, DOI 10.1074/jbc.M402781200
   NAITO C, 1978, JPN J GERIATR, V15, P187
   Palmer CNA, 1998, MOL PHARMACOL, V53, P14, DOI 10.1124/mol.53.1.14
   Perry L.M., 1980, Medicinal Plants of East and Southeast Asia: Attributed Properties and Uses, P149
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Roglans N, 2002, J PHARMACOL EXP THER, V302, P232, DOI 10.1124/jpet.302.1.232
   Sabu MC, 2002, J ETHNOPHARMACOL, V81, P155, DOI 10.1016/S0378-8741(02)00034-X
   Sakurai H, 1996, BBA-MOL BASIS DIS, V1316, P132, DOI 10.1016/0925-4439(96)00022-1
   Sarti C, 2006, J DIABETES COMPLICAT, V20, P121, DOI 10.1016/j.jdiacomp.2005.06.014
   Sasaki M, 2001, MECH AGEING DEV, V122, P1695, DOI 10.1016/S0047-6374(01)00281-0
   Schoonjans K, 1997, CURR OPIN LIPIDOL, V8, P159, DOI 10.1097/00041433-199706000-00006
   Smith S, 1998, ENV NUTR, V11, P7
   Sonnenberg GE, 2004, OBES RES, V12, P180, DOI 10.1038/oby.2004.24
   Stentz FB, 2004, DIABETES, V53, P2079, DOI 10.2337/diabetes.53.8.2079
   THAKUR CP, 1985, EXPERIENTIA, V41, P423, DOI 10.1007/BF02004540
   THORBURN AW, 1989, AM J CLIN NUTR, V49, P1155, DOI 10.1093/ajcn/49.6.1155
   TOBEY TA, 1982, METABOLISM, V31, P608, DOI 10.1016/0026-0495(82)90100-7
   UUSITUPA MIJ, 1994, AM J CLIN NUTR, V59, p753S, DOI 10.1093/ajcn/59.3.753S
   VUILLEUMIER S, 1993, AM J CLIN NUTR, V58, P733
   Williams CM, 2004, BIOCHEM SOC T, V32, P994, DOI 10.1042/BST0320994
   Wu LY, 2004, EUR J NUTR, V43, P116, DOI 10.1007/s00394-004-0450-x
   Yokozawa T, 2007, BRIT J NUTR, V97, P1187, DOI 10.1017/S0007114507691971
   Yokozawa T, 2007, J AGR FOOD CHEM, V55, P7744, DOI 10.1021/jf072105s
   Zhang YJ, 2001, CHEM PHARM BULL, V49, P537, DOI 10.1248/cpb.49.537
NR 76
TC 70
Z9 75
U1 2
U2 16
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD FEB 28
PY 2010
VL 103
IS 4
BP 502
EP 512
DI 10.1017/S0007114509991978
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 559EM
UT WOS:000274804900006
PM 19878614
OA Bronze
DA 2025-06-11
ER

PT J
AU Nuotio-Antar, AM
   Hachey, DL
   Hasty, AH
AF Nuotio-Antar, Alli M.
   Hachey, David L.
   Hasty, Alyssa H.
TI Carbenoxolone treatment attenuates symptoms of metabolic syndrome and
   atherogenesis in obese, hyperlipidemic mice
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE 11 beta-hydroxysteroid dehydrogenase type 1; obesity; agouti;
   low-density; lipoprotein receptor
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; HEPATIC INSULIN
   SENSITIVITY; GAP-JUNCTIONAL COMMUNICATION; ADIPOSE-TISSUE;
   GLUCOCORTICOID-RECEPTOR; SELECTIVE-INHIBITION; VISCERAL OBESITY; CHRONIC
   STRESS; EXPRESSION; CORTISOL
AB Nuotio-Antar AM, Hachey DL, Hasty AH. Carbenoxolone treatment attenuates symptoms of metabolic syndrome and atherogenesis in obese, hyperlipidemic mice. Am J Physiol Endocrinol Metab 293: E1517-E1528, 2007. First published September 18, 2007; doi: 10.1152/ajpendo.00522.2007. - Glucocorticoids, which are well established to regulate body fat mass distribution, adipocyte lipolysis, hepatic gluconeogenesis, and hepatocyte VLDL secretion, are speculated to play a role in the pathology of metabolic syndrome. Recent focus has been on the activity of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1), which is capable of regenerating, and thus amplifying, glucocorticoids in key metabolic tissues such as liver and adipose tissue. To determine the effects of global 11 beta-HSD1 inhibition on metabolic syndrome risk factors, we subcutaneously injected "Western"-type diet-fed hyperlipidemic mice displaying moderate or severe obesity [LDL receptor ( LDLR)-deficient (LDLR-/-) mice and mice derived from heterozygous agouti (A(y)/a) and homozygous LDLR-/- breeding pairs (A(y)/a; LDLR-/- mice)] with the nonselective 11 beta-HSD inhibitor carbenoxolone for 4 wk. Body composition throughout the study, end-point fasting plasma, and extent of hepatic steatosis and atherosclerosis were assessed. This route of treatment led to detection of high levels of carbenoxolone in liver and fat and resulted in decreased weight gain due to reduced body fat mass in both mouse models. However, only A(y)/a; LDLR-/- mice showed an effect of 11 beta-HSD1 inhibition on fasting insulin and plasma lipids, coincident with a reduction in VLDL due to mildly increased VLDL clearance and dramatically decreased hepatic triglyceride production. A(y)/a; LDLR-/- mice also showed a greater effect of the drug on reducing atherosclerotic lesion formation. These findings indicate that subcutaneous injection of an 11 beta-HSD1 inhibitor allows for the targeting of the enzyme in not only liver, but also adipose tissue, and attenuates many metabolic syndrome risk factors, with more pronounced effects in cases of severe obesity and hyperlipidemia.
C1 Vanderbilt Univ, Ctr Med, Dept Mol Physiol & Biophys, Nashville, TN 37232 USA.
   Vanderbilt Univ, Ctr Med, Dept Pharmacol, Nashville, TN 37232 USA.
C3 Vanderbilt University; Vanderbilt University
RP Hasty, AH (corresponding author), 702 Light Hall,23rd Ave S, Nashville, TN 37027 USA.
EM alyssa.hasty@vanderbilt.edu
RI Hasty, Alyssa/AAA-2757-2020
OI Hasty, Alyssa/0000-0001-7302-8045; Antar, Alli/0000-0002-1830-4868
FU NIDDK NIH HHS [DK0588404, DK020593, DK-59637] Funding Source: Medline
CR Alberts P, 2003, ENDOCRINOLOGY, V144, P4755, DOI 10.1210/en.2003-0344
   Alberts P, 2002, DIABETOLOGIA, V45, P1528, DOI 10.1007/s00125-002-0959-6
   Andrew R, 2005, DIABETES, V54, P1364, DOI 10.2337/diabetes.54.5.1364
   Andrews RC, 2003, J CLIN ENDOCR METAB, V88, P285, DOI 10.1210/jc.2002-021194
   Barf T, 2002, J MED CHEM, V45, P3813, DOI 10.1021/jm025530f
   Berthiaume M, 2007, AM J PHYSIOL-ENDOC M, V293, pE1045, DOI 10.1152/ajpendo.00276.2007
   Berthiaume M, 2007, ENDOCRINOLOGY, V148, P2391, DOI 10.1210/en.2006-1199
   Bujalska IJ, 1997, LANCET, V349, P1210, DOI 10.1016/S0140-6736(96)11222-8
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Coenen KR, 2007, AM J PHYSIOL-ENDOC M, V293, pE492, DOI 10.1152/ajpendo.00171.2007
   Coenen KR, 2007, DIABETES, V56, P564, DOI 10.2337/db06-1375
   DAVIDSON JS, 1988, J PHARMACOL EXP THER, V246, P1104
   Dolinsky VW, 2004, BIOCHEM J, V378, P967, DOI 10.1042/BJ20031320
   Eugenín EA, 1998, AM J PHYSIOL-GASTR L, V274, pG1109, DOI 10.1152/ajpgi.1998.274.6.G1109
   Eugenín EA, 2003, J IMMUNOL, V170, P1320, DOI 10.4049/jimmunol.170.3.1320
   Fan W, 1997, NATURE, V385, P165, DOI 10.1038/385165a0
   Gilham D, 2003, FASEB J, V17, P1685, DOI 10.1096/fj.02-0728fje
   Gregoire FM, 1998, PHYSIOL REV, V78, P783, DOI 10.1152/physrev.1998.78.3.783
   Hermanowski-Vosatka A, 2005, J EXP MED, V202, P517, DOI 10.1084/jem.20050119
   JEANRENAUD B, 1960, J BIOL CHEM, V235, P2217
   Kannisto K, 2004, J CLIN ENDOCR METAB, V89, P4414, DOI 10.1210/jc.2004-0153
   Kershaw EE, 2005, DIABETES, V54, P1023, DOI 10.2337/diabetes.54.4.1023
   Kotelevtsev Y, 1997, P NATL ACAD SCI USA, V94, P14924, DOI 10.1073/pnas.94.26.14924
   LATIF SA, 1992, STEROIDS, V57, P494, DOI 10.1016/0039-128X(92)90044-A
   Leshchenko Y, 2006, BMC NEUROSCI, V7, DOI 10.1186/1471-2202-7-3
   Livingstone DEW, 2003, J PHARMACOL EXP THER, V305, P167, DOI 10.1124/jpet.102.044842
   Livingstone DEW, 2000, J ENDOCRINOL, V167, P533, DOI 10.1677/joe.0.1670533
   Masuzaki H, 2003, J CLIN INVEST, V112, P83, DOI [10.1172/JCI200317845, 10.1172/JCI17845]
   Masuzaki H, 2001, SCIENCE, V294, P2166, DOI 10.1126/science.1066285
   Masuzaki Hiroaki, 2003, Current Drug Targets - Immune Endocrine and Metabolic Disorders, V3, P255
   MERCER WR, 1992, ENDOCRINOLOGY, V130, P540, DOI 10.1210/en.130.1.540
   MONDER C, 1993, J STEROID BIOCHEM, V45, P161, DOI 10.1016/0960-0760(93)90136-K
   Morton NM, 2004, DIABETES, V53, P931, DOI 10.2337/diabetes.53.4.931
   Morton NM, 2001, J BIOL CHEM, V276, P41293, DOI 10.1074/jbc.M103676200
   Nathanson MH, 1999, GASTROENTEROLOGY, V116, P1176, DOI 10.1016/S0016-5085(99)70021-1
   Nelles E, 1996, P NATL ACAD SCI USA, V93, P9565, DOI 10.1073/pnas.93.18.9565
   Newell-Price J, 2006, LANCET, V367, P1605, DOI 10.1016/S0140-6736(06)68699-6
   Nuotio-Antar AM, 2006, J STEROID BIOCHEM, V99, P93, DOI 10.1016/j.jsbmb.2006.01.011
   Obici S, 2002, J CLIN INVEST, V109, P1599, DOI [10.1172/JCI0215258, 10.1172/JCI200215258]
   PAIGEN B, 1987, ATHEROSCLEROSIS, V68, P231, DOI 10.1016/0021-9150(87)90202-4
   Paterson JM, 2004, P NATL ACAD SCI USA, V101, P7088, DOI 10.1073/pnas.0305524101
   Peeke PM, 1995, ANN NY ACAD SCI, V771, P665, DOI 10.1111/j.1749-6632.1995.tb44719.x
   PRINCEN HMG, 1989, BIOCHEM J, V262, P341, DOI 10.1042/bj2620341
   Quinkler M, 2003, J CLIN ENDOCR METAB, V88, P2384, DOI 10.1210/jc.2003-030138
   Rask E, 2001, J CLIN ENDOCR METAB, V86, P1418, DOI 10.1210/jc.86.3.1418
   Rauz S, 2003, QJM-INT J MED, V96, P481, DOI 10.1093/qjmed/hcg085
   REBUFFESCRIVE M, 1992, PHYSIOL BEHAV, V52, P583, DOI 10.1016/0031-9384(92)90351-2
   ROLAND BL, 1995, MOL CELL ENDOCRINOL, V111, pR1, DOI 10.1016/0303-7207(95)03559-P
   Rönquist-Nii Y, 2005, J PHARMACEUT BIOMED, V37, P341, DOI 10.1016/j.jpba.2004.10.044
   Sandeep TC, 2005, DIABETES, V54, P872, DOI 10.2337/diabetes.54.3.872
   Saraswathi V, 2006, J LIPID RES, V47, P1406, DOI 10.1194/jlr.M600159-JLR200
   SISTARE FD, 1985, J BIOL CHEM, V260, P2754
   Stollenwerk MM, 2005, ATHEROSCLEROSIS, V179, P247, DOI 10.1016/j.atherosclerosis.2004.12.002
   TASKINEN MR, 1983, J CLIN ENDOCR METAB, V57, P619, DOI 10.1210/jcem-57-3-619
   Tomlinson JW, 2007, J CLIN ENDOCR METAB, V92, P857, DOI 10.1210/jc.2006-2325
   WALKER BR, 1995, J CLIN ENDOCR METAB, V80, P3155, DOI 10.1210/jc.80.11.3155
   WALKER BR, 1992, CLIN ENDOCRINOL, V37, P483, DOI 10.1111/j.1365-2265.1992.tb01478.x
   Weisberg AD, 2005, ARTERIOSCL THROM VAS, V25, P365, DOI 10.1161/01.ATV.0000152356.85791.52
   Yanagiya T, 2007, OBESITY, V15, P572, DOI 10.1038/oby.2007.547
   Zhang YL, 2004, J BIOL CHEM, V279, P19362, DOI 10.1074/jbc.M400220200
   2000, WORLD HLTH ORGAN TEC, V894, P1
NR 61
TC 61
Z9 66
U1 0
U2 8
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD DEC
PY 2007
VL 293
IS 6
BP E1517
EP E1528
DI 10.1152/ajpendo.00522.2007
PG 12
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 239HU
UT WOS:000251510200007
PM 17878220
DA 2025-06-11
ER

PT J
AU Liu, TM
   Xu, Y
   Yi, CX
   Tong, QC
   Cai, DS
AF Liu, Tiemin
   Xu, Yong
   Yi, Chun-Xia
   Tong, Qingchun
   Cai, Dongsheng
TI The hypothalamus for whole-body physiology: from metabolism to aging
SO PROTEIN & CELL
LA English
DT Review
DE neuron; metabolism; hypothalamus; obesity; aging
ID ESTROGEN-RECEPTOR-ALPHA; HIGH-FAT-DIET; NF-KAPPA-B;
   NUCLEUS-TRACTUS-SOLITARIUS; DEPRESSION-LIKE BEHAVIORS; NEURONS REGULATE
   ENERGY; SEROTONIN 2C RECEPTORS; CENTRAL-NERVOUS-SYSTEM; BROWN
   ADIPOSE-TISSUE; DORSAL RAPHE NUCLEUS
AB Obesity and aging are two important epidemic factors for metabolic syndrome and many other health issues, which contribute to devastating diseases such as cardiovascular diseases, stroke and cancers. The brain plays a central role in controlling metabolic physiology in that it integrates information from other metabolic organs, sends regulatory projections and orchestrates the whole-body function. Emerging studies suggest that brain dysfunction in sensing various internal cues or processing external cues may have profound effects on metabolic and other physiological functions. This review highlights brain dysfunction linked to genetic mutations, sex, brain inflammation, microbiota, stress as causes for whole-body pathophysiology, arguing brain dysfunction as a root cause for the epidemic of aging and obesity-related disorders. We also speculate key issues that need to be addressed on how to reveal relevant brain dysfunction that underlines the development of these disorders and diseases in order to develop new treatment strategies against these health problems.
C1 [Liu, Tiemin] Fudan Univ, Inst Metab & Integrat Biol, State Key Lab Genet Engn, Dept Endocrinol & Metab,Human Phenome Inst, Shanghai 200438, Peoples R China.
   [Liu, Tiemin] Fudan Univ, Collaborat Innovat Ctr Genet & Dev, Zhongshan Hosp, Sch Life Sci, Shanghai 200438, Peoples R China.
   [Xu, Yong] Baylor Coll Med, Dept Pediat, Dept Mol & Cellular Biol, Childrens Nutr Res Ctr, One Baylor Plaza, Houston, TX 77030 USA.
   [Yi, Chun-Xia] Univ Amsterdam, Dept Endocrinol & Metab, Amsterdam Univ Med Ctr, Amsterdam Gastroenterol Endocrinol Metab, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
   [Tong, Qingchun] Univ Texas McGovern Med Sch, Dept Neurobiol & Anat, Brown Fdn Inst Mol Med, Grad Program Neurosci MD Anderson UTHlth Gr, Houston, TX 77030 USA.
   [Cai, Dongsheng] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA.
C3 Fudan University; Fudan University; Baylor College of Medicine;
   University of Amsterdam; Montefiore Medical Center; Albert Einstein
   College of Medicine; Yeshiva University
RP Liu, TM (corresponding author), Fudan Univ, Inst Metab & Integrat Biol, State Key Lab Genet Engn, Dept Endocrinol & Metab,Human Phenome Inst, Shanghai 200438, Peoples R China.; Liu, TM (corresponding author), Fudan Univ, Collaborat Innovat Ctr Genet & Dev, Zhongshan Hosp, Sch Life Sci, Shanghai 200438, Peoples R China.; Tong, QC (corresponding author), Univ Texas McGovern Med Sch, Dept Neurobiol & Anat, Brown Fdn Inst Mol Med, Grad Program Neurosci MD Anderson UTHlth Gr, Houston, TX 77030 USA.; Cai, DS (corresponding author), Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA.
EM tiemin_liu@fudan.edu.cn; qingchun.tong@uth.tmc.edu;
   dongsheng.cai@einsteinmed.org
RI Cai, Dongsheng/CAH-8271-2022; çŽ‹, æ/AAU-6965-2020; Yi,
   Chun-Xia/J-4068-2016
OI Xu, Yong/0000-0002-4908-1572; Liu, Tiemin/0000-0003-2077-7653; Yi,
   Chun-Xia/0000-0003-1184-4615; Tong, Qingchun/0000-0002-4561-2540
FU National Key RAMP;D Program of China [2019YFA0801900, 2018YFA0800300];
   National Natural Science Foundation of China [91749104, 31971074];
   Science and Technology Innovation Action Plan of Shanghai Science and
   Technology Committee [18140901300]; Open Research Fund of the National
   Key Laboratory of Genetic Engineering [SKLGE1803]; Shanghai Pujiang
   Talent Project [18PJ1400700]
FX We apologize for not being able to cite many additional important
   contributions from peers due to space limitation. This study was funded
   by the National Key R&D Program of China
   (2019YFA0801900,2018YFA0800300), the National Natural Science Foundation
   of China (91749104 and 31971074), the Science and Technology Innovation
   Action Plan of Shanghai Science and Technology Committee (18140901300),
   the Open Research Fund of the National Key Laboratory of Genetic
   Engineering (SKLGE1803), the Shanghai Pujiang Talent Project
   (18PJ1400700) to T.L., and Dr. Tong is the holder of Cullen Chair in
   Molecular Medicine at McGovern Medical School of UTHealth.
CR Adak A, 2019, CELL MOL LIFE SCI, V76, P473, DOI 10.1007/s00018-018-2943-4
   Al Tuwaijri A, 2019, J PEDIATR ENDOCR MET, V32, P409, DOI 10.1515/jpem-2018-0505
   Alcedo J, 2004, NEURON, V41, P45, DOI 10.1016/S0896-6273(03)00816-X
   Alkemade A, 2012, J CLIN ENDOCR METAB, V97, pE925, DOI 10.1210/jc.2011-3259
   Apfeld J, 1999, NATURE, V402, P804, DOI 10.1038/45544
   Appiakannan HS, 2019, PHYSIOL BEHAV, V204, P100, DOI 10.1016/j.physbeh.2019.01.014
   Arnold AP, 2014, EXP NEUROL, V259, P2, DOI 10.1016/j.expneurol.2014.01.021
   Artan M, 2016, GENE DEV, V30, P1047, DOI 10.1101/gad.279448.116
   Asarian L, 2007, ENDOCRINOLOGY, V148, P5656, DOI 10.1210/en.2007-0341
   Attia E, 2010, ANNU REV MED, V61, P425, DOI 10.1146/annurev.med.050208.200745
   Auvinen HE, 2012, J ENDOCRINOL, V214, P191, DOI 10.1530/JOE-12-0056
   Bäckhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Baraboi ED, 2010, EUR J NEUROSCI, V32, P826, DOI 10.1111/j.1460-9568.2010.07318.x
   Baron R, 2014, AGING CELL, V13, P584, DOI 10.1111/acel.12210
   Bartolomucci A, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004331
   Baruch K, 2014, SCIENCE, V346, P89, DOI 10.1126/science.1252945
   Barzilai N, 2016, CELL METAB, V23, P1060, DOI 10.1016/j.cmet.2016.05.011
   Baufeld C, 2016, ACTA NEUROPATHOL, V132, P361, DOI 10.1007/s00401-016-1595-4
   Benz V, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0037794
   Berglund ED, 2013, J CLIN INVEST, V123, P5061, DOI 10.1172/JCI70338
   Berry A, 2012, PSYCHONEUROENDOCRINO, V37, P762, DOI 10.1016/j.psyneuen.2011.09.007
   Beutler LR, 2020, ELIFE, V9, DOI 10.7554/eLife.55909
   Block ML, 2007, NAT REV NEUROSCI, V8, P57, DOI 10.1038/nrn2038
   Boulais J, 2010, MOL SYST BIOL, V6, DOI 10.1038/msb.2010.80
   Bravo JA, 2011, P NATL ACAD SCI USA, V108, P16050, DOI 10.1073/pnas.1102999108
   Breton J, 2016, CELL METAB, V23, P324, DOI 10.1016/j.cmet.2015.10.017
   Brighton CA, 2015, ENDOCRINOLOGY, V156, P3961, DOI 10.1210/en.2015-1321
   BROADWELL RD, 1983, P NATL ACAD SCI-BIOL, V80, P7352, DOI 10.1073/pnas.80.23.7352
   Buckman LB, 2015, MOL METAB, V4, P58, DOI 10.1016/j.molmet.2014.10.001
   Burke LK, 2014, ENDOCRINOLOGY, V155, P3732, DOI 10.1210/en.2014-1223
   Burnett CJ, 2016, NEURON, V92, P187, DOI 10.1016/j.neuron.2016.08.032
   Burns JC, 2020, ELIFE, V9, DOI 10.7554/eLife.57495
   BUTERA PC, 1989, BRAIN RES, V491, P266, DOI 10.1016/0006-8993(89)90062-0
   Cai DS, 2019, CELL METAB, V30, P19, DOI 10.1016/j.cmet.2019.05.021
   Callewaert F, 2009, FASEB J, V23, P232, DOI 10.1096/fj.08-113456
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2019, NAT METAB, V1, P34, DOI 10.1038/s42255-018-0017-4
   Cani PD, 2004, BRIT J NUTR, V92, P521, DOI 10.1079/BJN20041225
   Cannon B, 2004, PHYSIOL REV, V84, P277, DOI 10.1152/physrev.00015.2003
   Cao XH, 2014, J CLIN INVEST, V124, P4351, DOI 10.1172/JCI74726
   Cassidy RM, 2019, SCI ADV, V5, DOI 10.1126/sciadv.aav1640
   Chen XQ, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002709
   Chen YC, 2016, DEV CELL, V39, P209, DOI 10.1016/j.devcel.2016.08.021
   Chiba S, 2012, PROG NEURO-PSYCHOPH, V39, P112, DOI 10.1016/j.pnpbp.2012.05.018
   Clément K, 1998, NATURE, V392, P398, DOI 10.1038/32911
   Clemente JC, 2012, CELL, V148, P1258, DOI 10.1016/j.cell.2012.01.035
   Cohen P, 2001, J CLIN INVEST, V108, P1113, DOI 10.1172/JCI13914
   Correa SM, 2015, CELL REP, V10, P62, DOI 10.1016/j.celrep.2014.12.011
   Cryan JF, 2019, PHYSIOL REV, V99, P1877, DOI 10.1152/physrev.00018.2018
   D'Agostino G, 2018, CELL METAB, V28, P619, DOI 10.1016/j.cmet.2018.07.017
   d'Anglemont de Tassigny X, 2007, P NATL ACAD SCI USA, V104, P10714, DOI 10.1073/pnas.0704114104
   Dalby MJ, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-33928-4
   Dallman MF, 2010, TRENDS ENDOCRIN MET, V21, P159, DOI 10.1016/j.tem.2009.10.004
   Dalmasso C, 2011, PHYSIOL BEHAV, V104, P398, DOI 10.1016/j.physbeh.2011.04.029
   Davis KE, 2014, HORM BEHAV, V66, P196, DOI 10.1016/j.yhbeh.2014.02.004
   de Souza FSJ, 2011, EUR J PHARMACOL, V660, P181, DOI 10.1016/j.ejphar.2010.10.114
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   De Vries GJ, 2002, J NEUROSCI, V22, P9005
   Delzenne NM, 2005, BRIT J NUTR, V93, pS157, DOI 10.1079/BJN20041342
   Deussing JM, 2018, PHYSIOL REV, V98, P2225, DOI 10.1152/physrev.00042.2017
   Dietrich MO, 2015, CELL, V160, P1222, DOI 10.1016/j.cell.2015.02.024
   Dorfman MD, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms14556
   DREWETT RF, 1973, NATURE, V242, P476, DOI 10.1038/242476a0
   Durieux J, 2011, CELL, V144, P79, DOI 10.1016/j.cell.2010.12.016
   Encinas JM, 2011, CELL STEM CELL, V8, P566, DOI 10.1016/j.stem.2011.03.010
   Fagman JB, 2015, FASEB J, V29, P1540, DOI 10.1096/fj.14-259234
   Fan WQ, 2005, DIABETES, V54, P1000, DOI 10.2337/diabetes.54.4.1000
   Farooqi IS, 2008, FRONT HORM RES, V36, P1, DOI 10.1159/000115333
   Farooqi IS, 2006, ENDOCR REV, V27, P710, DOI 10.1210/er.2006-0040
   Finan B, 2012, NAT MED, V18, P1847, DOI 10.1038/nm.3009
   Flier JS, 2004, CELL, V116, P337, DOI 10.1016/S0092-8674(03)01081-X
   Foryst-Ludwig A, 2008, PLOS GENET, V4, DOI 10.1371/journal.pgen.1000108
   FRIEDMAN DB, 1988, GENETICS, V118, P75
   FRIEDMAN DB, 1988, J GERONTOL, V43, pB102, DOI 10.1093/geronj/43.4.B102
   Friedman J, 2016, J CLIN INVEST, V126, P4727, DOI 10.1172/JCI91578
   Gao Q, 2007, NAT MED, V13, P89, DOI 10.1038/nm1525
   Gao Y, 2017, CELL REP, V18, P583, DOI 10.1016/j.celrep.2016.12.072
   Gao YQ, 2017, CELL REP, V20, P3034, DOI 10.1016/j.celrep.2017.09.008
   Gao YQ, 2017, MOL METAB, V6, P897, DOI 10.1016/j.molmet.2017.06.008
   Gao Y, 2014, GLIA, V62, P17, DOI 10.1002/glia.22580
   García-Cáceres C, 2019, NAT NEUROSCI, V22, P7, DOI 10.1038/s41593-018-0286-y
   García-Cáceres C, 2016, CELL, V166, P867, DOI 10.1016/j.cell.2016.07.028
   García-Eguren G, 2019, J ENDOCRINOL, V242, P65, DOI 10.1530/JOE-19-0168
   Geary N, 2001, ENDOCRINOLOGY, V142, P4751, DOI 10.1210/en.142.11.4751
   Gerisch B, 2001, DEV CELL, V1, P841, DOI 10.1016/S1534-5807(01)00085-5
   Ginhoux F, 2010, SCIENCE, V330, P841, DOI 10.1126/science.1194637
   Godier LR, 2014, FRONT PSYCHOL, V5, DOI 10.3389/fpsyg.2014.00778
   Goldmann T, 2016, NAT IMMUNOL, V17, P797, DOI 10.1038/ni.3423
   Gomes JAS, 2020, J NUTR BIOCHEM, V77, DOI 10.1016/j.jnutbio.2019.108317
   GOODFELLOW PN, 1993, ANNU REV GENET, V27, P71, DOI 10.1146/annurev.ge.27.120193.000443
   Goswami C, 2018, J NUTR BIOCHEM, V57, P130, DOI 10.1016/j.jnutbio.2018.03.009
   Grabert K, 2016, NAT NEUROSCI, V19, P504, DOI 10.1038/nn.4222
   Greenberg DA, 2006, NAT MED, V12, P884, DOI 10.1038/nm0806-884
   Grove KL, 2010, INT J OBESITY, V34, P989, DOI 10.1038/ijo.2010.12
   Grumbach MM, 1999, J CLIN ENDOCR METAB, V84, P4677, DOI 10.1210/jc.84.12.4677
   Haas E, 2009, CIRC RES, V104, P288, DOI 10.1161/CIRCRESAHA.108.190892
   Harris RBS, 2017, HORM BEHAV, V89, P64, DOI 10.1016/j.yhbeh.2016.12.008
   Harris RBS, 2015, AM J PHYSIOL-REG I, V308, pR250, DOI 10.1152/ajpregu.00361.2014
   Hatori M, 2012, CELL METAB, V15, P848, DOI 10.1016/j.cmet.2012.04.019
   Heine PA, 2000, P NATL ACAD SCI USA, V97, P12729, DOI 10.1073/pnas.97.23.12729
   Heneka MT, 2015, LANCET NEUROL, V14, P388, DOI 10.1016/S1474-4422(15)70016-5
   Herzog H, 2020, NAT REV ENDOCRINOL, V16, P75, DOI 10.1038/s41574-019-0298-z
   Hildrum B, 2007, BMC PUBLIC HEALTH, V7, DOI 10.1186/1471-2458-7-220
   Holder JL, 2000, HUM MOL GENET, V9, P101
   Hong KW, 2012, OBESITY, V20, P1871, DOI 10.1038/oby.2011.352
   Hood S, 2018, FRONT BEHAV NEUROSCI, V12, DOI 10.3389/fnbeh.2018.00004
   Horvath TL, 2010, P NATL ACAD SCI USA, V107, P14875, DOI 10.1073/pnas.1004282107
   Horvath TL, 2005, NAT NEUROSCI, V8, P561, DOI 10.1038/nn1453
   Huang QL, 1998, ENDOCRINOLOGY, V139, P1524, DOI 10.1210/en.139.4.1524
   Huszar D, 1997, CELL, V88, P131, DOI 10.1016/S0092-8674(00)81865-6
   Inada H, 2006, GENETICS, V172, P2239, DOI 10.1534/genetics.105.050013
   Ishii M, 2015, CELL METAB, V22, P761, DOI 10.1016/j.cmet.2015.08.016
   Jameson KG, 2020, MOL CELL, V78, P577, DOI 10.1016/j.molcel.2020.03.006
   Jarvie BC, 2012, J COMP NEUROL, V520, P3863, DOI 10.1002/cne.23127
   Jennings JH, 2015, CELL, V160, P516, DOI 10.1016/j.cell.2014.12.026
   Jeong Dae-Eun, 2012, Frontiers in Genetics, V3, P218, DOI 10.3389/fgene.2012.00218
   Jia KL, 2002, DEVELOPMENT, V129, P221
   Jones MEE, 2000, P NATL ACAD SCI USA, V97, P12735, DOI 10.1073/pnas.97.23.12735
   Kalsbeek MJT, 2020, JCI INSIGHT, V5, DOI 10.1172/jci.insight.133868
   Kalyani M, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0166416
   Karaki S, 2006, CELL TISSUE RES, V324, P353, DOI 10.1007/s00441-005-0140-x
   KENYON C, 1993, NATURE, V366, P461, DOI 10.1038/366461a0
   Kenyon CJ, 2010, NATURE, V464, P504, DOI 10.1038/nature08980
   Kessler RC, 1997, ANNU REV PSYCHOL, V48, P191, DOI 10.1146/annurev.psych.48.1.191
   Kim ER, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-17578-7
   Kim ER, 2015, J NEUROSCI, V35, P10440, DOI 10.1523/JNEUROSCI.1110-15.2015
   Kim JG, 2014, NAT NEUROSCI, V17, P908, DOI 10.1038/nn.3725
   Kim JD, 2019, CELL METAB, V30, P952, DOI 10.1016/j.cmet.2019.08.010
   Kliewer SA, 2015, DIGEST DIS, V33, P327, DOI 10.1159/000371670
   Klingbeil E, 2018, AM J PHYSIOL-REG I, V315, pR1254, DOI 10.1152/ajpregu.00037.2018
   Kothari V, 2016, J INFLAMM RES, V9, P27, DOI 10.2147/JIR.S86917
   KOWALSKI C, 1992, BRAIN RES, V582, P38, DOI 10.1016/0006-8993(92)90314-Y
   Krieger JP, 2016, DIABETES, V65, P34, DOI 10.2337/db15-0973
   Krieger JP, 2015, PHYSIOL BEHAV, V152, P372, DOI 10.1016/j.physbeh.2015.06.001
   Krude H, 1998, NAT GENET, V19, P155, DOI 10.1038/509
   Kuno R, 2005, J NEUROIMMUNOL, V162, P89, DOI 10.1016/j.jneuroim.2005.01.015
   Lagerlöf O, 2016, SCIENCE, V351, P1293, DOI 10.1126/science.aad5494
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Lee SJ, 2009, CURR BIOL, V19, P715, DOI 10.1016/j.cub.2009.03.041
   Li G, 2005, DIABETOLOGIA, V48, P2376, DOI 10.1007/s00125-005-1943-8
   Li JX, 2012, NAT CELL BIOL, V14, P999, DOI 10.1038/ncb2562
   Li Y, 2018, NEURON, V97, P911, DOI 10.1016/j.neuron.2018.01.005
   Li Z, 2018, GUT, V67, P1269, DOI 10.1136/gutjnl-2017-314050
   Liao GY, 2019, P NATL ACAD SCI USA, V116, P3256, DOI 10.1073/pnas.1815744116
   Lin HY, 2005, DIABETES, V54, P1717, DOI 10.2337/diabetes.54.6.1717
   Liu YZ, 2014, BMC GASTROENTEROL, V14, DOI 10.1186/1471-230X-14-106
   Locke AE, 2015, NATURE, V518, P197, DOI 10.1038/nature14177
   Loid P, 2018, AM J MED GENET A, V176, P1972, DOI 10.1002/ajmg.a.40370
   Loskutova N, 2010, J ALZHEIMERS DIS, V20, P313, DOI 10.3233/JAD-2010-1364
   Lutter M, 2008, NAT NEUROSCI, V11, P752, DOI 10.1038/nn.2139
   Malyala A, 2008, J COMP NEUROL, V506, P895, DOI 10.1002/cne.21584
   Mangieri LR, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-017-02534-9
   Maniscalco JW, 2017, PHYSIOL BEHAV, V176, P195, DOI 10.1016/j.physbeh.2017.01.027
   de Morentin PBM, 2014, CELL METAB, V20, P41, DOI 10.1016/j.cmet.2014.03.031
   Masuda T, 2020, CELL REP, V30, P1271, DOI 10.1016/j.celrep.2020.01.010
   MATSUMOTO A, 1980, BRAIN RES, V190, P238, DOI 10.1016/0006-8993(80)91173-7
   Mattar L, 2012, PSYCHIAT RES, V200, P513, DOI 10.1016/j.psychres.2012.04.032
   Mauvais-Jarvis F, 2020, LANCET, V396, P565, DOI 10.1016/S0140-6736(20)31561-0
   Mazier W, 2019, MOL METAB, V28, P151, DOI 10.1016/j.molmet.2019.08.005
   Mazzone CM, 2020, NAT NEUROSCI, V23, P1253, DOI 10.1038/s41593-020-0684-9
   Meier SM, 2019, JAMA PSYCHIAT, V76, P924, DOI 10.1001/jamapsychiatry.2019.1119
   Melhorn SJ, 2010, AM J PHYSIOL-REG I, V299, pR813, DOI 10.1152/ajpregu.00820.2009
   Merchenthaler I, 2004, J COMP NEUROL, V473, P270, DOI 10.1002/cne.20128
   Michel C, 2005, HORM BEHAV, V48, P172, DOI 10.1016/j.yhbeh.2005.02.004
   Milanova IV, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00424
   MILLER MM, 1995, NEUROENDOCRINOLOGY, V61, P542, DOI 10.1159/000126878
   Mitchell RW, 2011, J NEUROCHEM, V117, P735, DOI 10.1111/j.1471-4159.2011.07245.x
   Molofsky AV, 2006, NATURE, V443, P448, DOI 10.1038/nature05091
   Mori T, 2006, GLIA, V54, P21, DOI 10.1002/glia.20350
   Morris JZ, 1996, NATURE, V382, P536, DOI 10.1038/382536a0
   Morselli E, 2016, INT J OBESITY, V40, P206, DOI 10.1038/ijo.2015.114
   Murphy KG, 2006, NATURE, V444, P854, DOI 10.1038/nature05484
   Murphy KG, 2005, J NEUROENDOCRINOL, V17, P519, DOI 10.1111/j.1365-2826.2005.01328.x
   Musatov S, 2007, P NATL ACAD SCI USA, V104, P2501, DOI 10.1073/pnas.0610787104
   Nasrallah CM, 2014, NAT REV ENDOCRINOL, V10, P650, DOI 10.1038/nrendo.2014.160
   Nederkoorn C, 2015, APPETITE, V93, P57, DOI 10.1016/j.appet.2015.03.032
   Nieh EH, 2015, CELL, V160, P528, DOI 10.1016/j.cell.2015.01.003
   Nohara K, 2013, AM J PHYSIOL-ENDOC M, V304, pE1321, DOI 10.1152/ajpendo.00620.2012
   Nohara K, 2011, ENDOCRINOLOGY, V152, P1661, DOI 10.1210/en.2010-1288
   Nonogaki K, 1998, NAT MED, V4, P1152, DOI 10.1038/2647
   O'Neill LAJ, 2016, NAT REV IMMUNOL, V16, P553, DOI 10.1038/nri.2016.70
   Oeckinghaus A, 2011, NAT IMMUNOL, V12, P695, DOI 10.1038/ni.2065
   Okamoto S, 2018, CELL REP, V22, P706, DOI 10.1016/j.celrep.2017.11.102
   Okura T, 2003, INT J OBESITY, V27, P1020, DOI 10.1038/sj.ijo.0802378
   Olah M, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-19737-2
   Ong CKS, 2007, CLIN MED RES, V5, P17, DOI 10.3121/cmr.2007.698
   Osterlund M, 1998, MOL BRAIN RES, V54, P175, DOI 10.1016/S0169-328X(97)00351-3
   Domecq JP, 2015, J CLIN ENDOCR METAB, V100, P363, DOI 10.1210/jc.2014-3421
   Padilla SL, 2016, NAT NEUROSCI, V19, P734, DOI 10.1038/nn.4274
   Paladini CA, 2014, NEUROSCIENCE, V282, P109, DOI 10.1016/j.neuroscience.2014.07.032
   Palmer BF, 2015, MOL CELL ENDOCRINOL, V402, P113, DOI 10.1016/j.mce.2014.11.029
   PALMER K, 1986, PHYSIOL BEHAV, V37, P187, DOI 10.1016/0031-9384(86)90404-X
   Patriquin Michelle A, 2017, Chronic Stress (Thousand Oaks), V1, DOI 10.1177/2470547017703993
   Patterson E, 2016, POSTGRAD MED J, V92, P286, DOI 10.1136/postgradmedj-2015-133285
   Perdiguero EG, 2015, NATURE, V518, P547, DOI 10.1038/nature13989
   Perry VH, 2010, NAT REV NEUROL, V6, P193, DOI 10.1038/nrneurol.2010.17
   Pivonello R, 2015, ENDOCR REV, V36, P385, DOI 10.1210/er.2013-1048
   Pizzagalli DA, 2014, ANNU REV CLIN PSYCHO, V10, P393, DOI 10.1146/annurev-clinpsy-050212-185606
   Prinz M, 2014, NAT REV NEUROSCI, V15, P300, DOI 10.1038/nrn3722
   Qiu J, 2018, ENDOCRINOLOGY, V159, P647, DOI 10.1210/en.2017-00793
   Qiu J, 2014, CELL METAB, V19, P682, DOI 10.1016/j.cmet.2014.03.004
   Qiu J, 2010, J NEUROSCI, V30, P1560, DOI 10.1523/JNEUROSCI.4816-09.2010
   Qu N, 2020, MOL PSYCHIATR, V25, P1006, DOI 10.1038/s41380-019-0506-1
   Ramachandrappa S, 2013, J CLIN INVEST, V123, P3042, DOI 10.1172/JCI68016
   Ramadori G, 2010, CELL METAB, V12, P78, DOI 10.1016/j.cmet.2010.05.010
   Ransohoff RM, 2016, NAT NEUROSCI, V19, P987, DOI 10.1038/nn.4338
   Razzoli Maria, 2015, Front Nutr, V1
   Razzoli M, 2017, NEUROSCI BIOBEHAV R, V76, P154, DOI 10.1016/j.neubiorev.2017.01.026
   Razzoli M, 2016, TRENDS ENDOCRIN MET, V27, P504, DOI 10.1016/j.tem.2016.04.007
   Ren DC, 2007, J CLIN INVEST, V117, P397, DOI 10.1172/JCI29417
   Reue K, 2017, PHYSIOL BEHAV, V176, P174, DOI 10.1016/j.physbeh.2017.02.040
   Riera CE, 2014, CELL, V157, P1023, DOI 10.1016/j.cell.2014.03.051
   Robichaud M, 2005, J NEUROENDOCRINOL, V17, P179, DOI 10.1111/j.1365-2826.2005.01292.x
   Rogers NH, 2009, ENDOCRINOLOGY, V150, P2161, DOI 10.1210/en.2008-1405
   Rottiers V, 2006, DEV CELL, V10, P473, DOI 10.1016/j.devcel.2006.02.008
   Round JL, 2009, NAT REV IMMUNOL, V9, P313, DOI 10.1038/nri2515
   Ruan HB, 2014, CELL, V159, P306, DOI 10.1016/j.cell.2014.09.010
   Ruud J, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms15259
   Sadagurski M, 2017, AGING CELL, V16, P652, DOI 10.1111/acel.12590
   Saito K, 2015, OBESITY, V23, P919, DOI 10.1002/oby.21099
   Samuel P, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0048425
   Santollo J, 2011, HORM BEHAV, V60, P86, DOI 10.1016/j.yhbeh.2011.03.009
   Sato T, 2003, BIOCHEM BIOPH RES CO, V300, P167, DOI 10.1016/S0006-291X(02)02774-2
   Satoh A, 2013, CELL METAB, V18, P416, DOI 10.1016/j.cmet.2013.07.013
   Schlenker EH, 2006, BRAIN RES, V1123, P89, DOI 10.1016/j.brainres.2006.09.035
   SCHWARTZ SM, 1981, AM J PHYSIOL, V240, pE499, DOI 10.1152/ajpendo.1981.240.5.E499
   Seib DRM, 2015, GERONTOLOGY, V61, P327, DOI 10.1159/000368575
   Seminara SB, 2003, NEW ENGL J MED, V349, P1614, DOI 10.1056/NEJMoa035322
   Shalata A, 2013, AM J HUM GENET, V93, P1061, DOI 10.1016/j.ajhg.2013.10.025
   Sharma G, 2013, ENDOCRINOLOGY, V154, P4136, DOI 10.1210/en.2013-1357
   Shen WJ, 2017, BBA-MOL BASIS DIS, V1863, P2477, DOI 10.1016/j.bbadis.2017.05.007
   Shi HF, 2009, FRONT NEUROENDOCRIN, V30, P396, DOI 10.1016/j.yfrne.2009.03.004
   Siervo M, 2009, HORM METAB RES, V41, P261, DOI 10.1055/s-0028-1119377
   Siljee JE, 2018, NAT GENET, V50, P180, DOI 10.1038/s41588-017-0020-9
   Sinha R, 2013, BIOL PSYCHIAT, V73, P827, DOI 10.1016/j.biopsych.2013.01.032
   SMITH EP, 1994, NEW ENGL J MED, V331, P1056, DOI 10.1056/NEJM199410203311604
   SNIDER WD, 1994, CELL, V77, P627, DOI 10.1016/0092-8674(94)90048-5
   Sominsky Luba, 2014, Front Psychol, V5, P434, DOI 10.3389/fpsyg.2014.00434
   Speakman JR, 2015, CURR OBES REP, V4, P73, DOI 10.1007/s13679-015-0143-1
   Srinivasan R, 2016, NEURON, V92, P1181, DOI 10.1016/j.neuron.2016.11.030
   Stamatakis AM, 2016, J NEUROSCI, V36, P302, DOI 10.1523/JNEUROSCI.1202-15.2016
   Stengel A, 2014, FRONT NEUROSCI-SWITZ, V8, DOI [10.3389/fnins.2014.00052, 10.3389/fnhum.2014.00595]
   Stergiakouli E, 2014, OBESITY, V22, P2252, DOI 10.1002/oby.20840
   Streit WJ, 2014, ACTA NEUROPATHOL COM, V2, DOI 10.1186/s40478-014-0142-6
   Stubbins RE, 2012, EUR J NUTR, V51, P861, DOI 10.1007/s00394-011-0266-4
   Su XH, 2012, CELL METAB, V16, P511, DOI 10.1016/j.cmet.2012.09.006
   Sugiyama MG, 2012, BIOCHEM CELL BIOL, V90, P124, DOI [10.1139/O11-067, 10.1139/o11-067]
   Sun F, 2013, AGING CELL, V12, P978, DOI 10.1111/acel.12134
   Swarbrick MM, 2011, OBESITY, V19, P2394, DOI 10.1038/oby.2011.79
   Sweeney P, 2017, TRENDS ENDOCRIN MET, V28, P437, DOI 10.1016/j.tem.2017.02.006
   Syková E, 2004, NEUROSCIENCE, V129, P861, DOI 10.1016/j.neuroscience.2004.06.077
   Tannenbaum C, 2016, BIOL SEX DIFFER, V7, DOI 10.1186/s13293-016-0066-x
   Tatsumi K, 2018, FRONT NEUROANAT, V12, DOI 10.3389/fnana.2018.00008
   Tay TL, 2017, NAT NEUROSCI, V20, P793, DOI 10.1038/nn.4547
   Taylor RC, 2013, CELL, V153, P1435, DOI 10.1016/j.cell.2013.05.042
   TECOTT LH, 1995, NATURE, V374, P542, DOI 10.1038/374542a0
   Terrill SJ, 2018, PHYSIOL BEHAV, V192, P17, DOI 10.1016/j.physbeh.2018.03.001
   Thaler JP, 2012, J CLIN INVEST, V122, P153, DOI 10.1172/JCI59660
   Thomson AW, 2009, NAT REV IMMUNOL, V9, P324, DOI 10.1038/nri2546
   Timmerman R, 2018, FRONT CELL NEUROSCI, V12, DOI 10.3389/fncel.2018.00242
   Timper K, 2017, DIS MODEL MECH, V10, P679, DOI 10.1242/dmm.026609
   Tolson KP, 2016, ENDOCRINOLOGY, V157, P4192, DOI 10.1210/en.2016-1501
   Tolson KP, 2014, J CLIN INVEST, V124, P3075, DOI 10.1172/JCI71075
   Tolson KP, 2010, J NEUROSCI, V30, P3803, DOI 10.1523/JNEUROSCI.5444-09.2010
   Tomiyama AJ, 2019, ANNU REV PSYCHOL, V70, P703, DOI 10.1146/annurev-psych-010418-102936
   Tramunt B, 2020, DIABETOLOGIA, V63, P453, DOI 10.1007/s00125-019-05040-3
   Tsai SF, 2018, NEUROENDOCRINOLOGY, V107, P147, DOI 10.1159/000491018
   Turcot V, 2018, NAT GENET, V50, P26, DOI 10.1038/s41588-017-0011-x
   Turer EE, 2018, DIS MODEL MECH, V11, DOI 10.1242/dmm.035451
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Tye KM, 2018, NEURON, V100, P436, DOI 10.1016/j.neuron.2018.10.001
   Ulrich-Lai YM, 2009, NAT REV NEUROSCI, V10, P397, DOI 10.1038/nrn2647
   Valdearcos M, 2017, CELL METAB, V26, P185, DOI 10.1016/j.cmet.2017.05.015
   Van Wagoner NJ, 1999, J NEUROIMMUNOL, V100, P124, DOI 10.1016/S0165-5728(99)00187-3
   vanVeen JE, 2019, SINGLE CELL PROFILIN, DOI [10.1101/549725, DOI 10.1101/549725]
   Venzala E, 2013, EUR NEUROPSYCHOPHARM, V23, P697, DOI 10.1016/j.euroneuro.2012.05.010
   Vercruysse P, 2018, FRONT MOL NEUROSCI, V11, DOI 10.3389/fnmol.2018.00002
   Veyrat-Durebex C, 2013, NEUROPEPTIDES, V47, P163, DOI 10.1016/j.npep.2013.01.001
   Vicente-Gutierrez C, 2019, NAT METAB, V1, P201, DOI 10.1038/s42255-018-0031-6
   Villeda SA, 2011, NATURE, V477, P90, DOI 10.1038/nature10357
   Wahl S, 2017, NATURE, V541, P81, DOI 10.1038/nature20784
   Wallen WJ, 2001, J NUTR, V131, P2351, DOI 10.1093/jn/131.9.2351
   Walters RG, 2010, NATURE, V463, P671, DOI 10.1038/nature08727
   Wang CM, 2019, J MOL ENDOCRINOL, V62, pR129, DOI 10.1530/JME-18-0165
   Wang CM, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-03796-7
   Wang ZS, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006979
   Webb EA, 2013, BRAIN, V136, P3096, DOI 10.1093/brain/awt218
   Wolden-Hanson T, 2004, AM J PHYSIOL-REG I, V287, pR138, DOI 10.1152/ajpregu.00465.2003
   WOODWARD CJH, 1989, BRIT J NUTR, V61, P445, DOI 10.1079/BJN19890134
   World Health Organization, 2015, Report on the Indians, P260
   Wu MV, 2009, CELL, V139, P61, DOI 10.1016/j.cell.2009.07.036
   Wu ZF, 2015, J NEUROSCI, V35, P3312, DOI 10.1523/JNEUROSCI.3720-14.2015
   Xiao R, 2015, J COMP PHYSIOL A, V201, P857, DOI 10.1007/s00359-015-1021-8
   Xiao YZ, 2020, CELL METAB, V31, P534, DOI 10.1016/j.cmet.2020.01.002
   Xu AW, 2007, ENDOCRINOLOGY, V148, P72, DOI 10.1210/en.2006-1119
   Xu BJ, 2003, NAT NEUROSCI, V6, P736, DOI 10.1038/nn1073
   Xu P, 2013, P NATL ACAD SCI USA, V110, P10759, DOI 10.1073/pnas.1308195110
   Xu PW, 2017, BIOL PSYCHIAT, V81, P737, DOI 10.1016/j.biopsych.2016.06.005
   Xu PW, 2015, J CLIN INVEST, V125, P2861, DOI 10.1172/JCI80941
   Xu Y, 2011, CELL METAB, V14, P453, DOI 10.1016/j.cmet.2011.08.009
   Xu Y, 2008, NEURON, V60, P582, DOI 10.1016/j.neuron.2008.09.033
   Xu YZ, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-11399-z
   Yan JQ, 2014, NAT MED, V20, P1001, DOI 10.1038/nm.3616
   Yang SB, 2012, NEURON, V75, P425, DOI 10.1016/j.neuron.2012.03.043
   Yang YB, 2014, OBESITY, V22, P2147, DOI 10.1002/oby.20811
   Yang YJ, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-08737-6
   Yaswen L, 1999, NAT MED, V5, P1066, DOI 10.1038/12506
   Yau YHC, 2013, MINERVA ENDOCRINOL, V38, P255
   Yeo GSH, 2004, NAT NEUROSCI, V7, P1187, DOI 10.1038/nn1336
   Yeo GSH, 1998, NAT GENET, V20, P111, DOI 10.1038/2404
   Yi CX, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms15143
   Yi CX, 2006, ENDOCRINOLOGY, V147, P283, DOI 10.1210/en.2005-1051
   Yu IC, 2013, DIABETES, V62, P411, DOI 10.2337/db12-0135
   Zhang G, 2013, NATURE, V497, P211, DOI 10.1038/nature12143
   Zhang YL, 2017, NATURE, V548, P52, DOI 10.1038/nature23282
   Zhang YL, 2017, CELL METAB, V25, P1091, DOI 10.1016/j.cmet.2017.04.002
   Zhu CJ, 2020, EMBO REP, V21, DOI 10.15252/embr.201949210
   Zhu LR, 2013, ENDOCRINOLOGY, V154, P150, DOI 10.1210/en.2012-2007
NR 318
TC 68
Z9 73
U1 2
U2 35
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1674-800X
EI 1674-8018
J9 PROTEIN CELL
JI Protein Cell
PD JUN
PY 2022
VL 13
IS 6
BP 394
EP 421
DI 10.1007/s13238-021-00834-x
EA APR 2021
PG 28
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 1D6BF
UT WOS:000637685700001
PM 33826123
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sági, B
   Késoi, I
   Vas, T
   Csiky, B
   Nagy, J
   Kovács, T
AF Sagi, Balazs
   Kesoi, Istvan
   Vas, Tibor
   Csiky, Botond
   Nagy, Judit
   Kovacs, Tibor
TI The prognostic role of heart rate recovery after exercise and metabolic
   syndrome in IgA nephropathy
SO BMC NEPHROLOGY
LA English
DT Article
DE Heart rate recovery; Chronic kidney disease; IgA nephropathy; Renal
   function; Cardiovascular risk
ID CHRONIC KIDNEY-DISEASE; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE;
   ASSOCIATION; PREDICTOR; MORTALITY; CAPACITY; MEN; HYPERGLYCEMIA;
   INFLAMMATION
AB Background Cardiovascular (CV) morbidity and mortality are higher in chronic kidney disease (CKD) than in the general population. Reduced heart rate recovery (HRR) is an independent risk factor for CV disease. The aim of the study was to determine the prognostic role of HRR in a homogenous group of CKD patients. Methods One hundred and twenty-five IgA nephropathy patients (82 male, 43 female, age 54.7 +/- 13 years) with CKD stage 1-4 were investigated and followed for average 70 months. We performed a graded exercise treadmill stress test. HRR was derived from the difference of the peak heart rate and the heart rate at 1 min after exercise. Patients were divided into two groups by the mean HRR value (22.9 beats/min). The composite (CV and renal) endpoints included all-cause mortality and any CV event such as stroke, myocardial infarction, revascularisation (CV) and end-stage renal disease, renal replacement therapy (renal). Results Patients with reduced HRR (< 23 bpm) had significantly more end point events (22/62 patients vs. 9/53 patients, p = 0.013) compared to the higher HRR (>= 23 bpm). Of the secondary the endpoints (CV or renal separately) rate of the renal endpoint was significantly higher in the lower HRR group (p = 0.029), while there was no significant difference in the CV endpoint between the two HRR groups (p = 0.285). Independent predictors of survival were eGFR and diabetes mellitus by using Cox regression analysis. Kaplan-Meier curves showed significant differences in metabolic syndrome and non-metabolic syndrome when examined at the combined endpoints (cardiovascular and renal) or at each endpoint separately. The primary endpoint rate was increased significantly with the increased number of metabolic syndrome component (Met.sy. comp. 0 vs. Met. sy. comp. 2+, primary endpoints, p = 0.012). Conclusion Our results showed that reduced HRR measured by treadmill exercise test has a predictive value for the prognosis of IgA nephropathy. The presence of metabolic syndrome may worsen the prognosis of IgA nephropathy.
C1 [Sagi, Balazs; Vas, Tibor; Csiky, Botond; Nagy, Judit; Kovacs, Tibor] Univ Pecs, Diabetol Ctr, Clin Ctr Med Sch, Dept Internal Med & Nephrol 2, Pacsirta St 1, H-7624 Pecs, Hungary.
   [Sagi, Balazs; Csiky, Botond] Fresenius Med Care Dialysis Ctr Pecs, Pecs, Hungary.
   [Kesoi, Istvan] Min Rehabil & Nighttime Sanat, Internal Med Dept, Hlth Ctr Komlo, Komlo, Hungary.
C3 University of Pecs
RP Nagy, J (corresponding author), Univ Pecs, Diabetol Ctr, Clin Ctr Med Sch, Dept Internal Med & Nephrol 2, Pacsirta St 1, H-7624 Pecs, Hungary.
EM judit.nagy@aok.pte.hu
CR Ali Kizilbash M, 2006, EUR HEART J, V27, P1592, DOI 10.1093/eurheartj/ehl043
   ARAI Y, 1989, AM J PHYSIOL, V256, pH132, DOI 10.1152/ajpheart.1989.256.1.H132
   Bikbov B, 2020, LANCET, V395, P709, DOI 10.1016/S0140-6736(20)30045-3
   Buchheit M, 2006, AM J PHYSIOL-HEART C, V291, pH451, DOI 10.1152/ajpheart.00008.2006
   Campos C, 2012, POSTGRAD MED, V124, P90, DOI 10.3810/pgm.2012.11.2615
   Carreira MAMQ, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0128123
   Chen MS, 2004, CIRCULATION, V110, P2851, DOI 10.1161/01.CIR.0000147539.39775.F4
   Cheng YLJ, 2003, DIABETES CARE, V26, P2052, DOI 10.2337/diacare.26.7.2052
   Cole CR, 2000, ANN INTERN MED, V132, P552, DOI 10.7326/0003-4819-132-7-200004040-00007
   Cole CR, 1999, NEW ENGL J MED, V341, P1351, DOI 10.1056/NEJM199910283411804
   CONVERSE RL, 1992, NEW ENGL J MED, V327, P1912, DOI 10.1056/NEJM199212313272704
   Davel AP, 2011, BRAZ J MED BIOL RES, V44, P920, DOI 10.1590/S0100-879X2011007500104
   Floege J, 2000, J AM SOC NEPHROL, V11, P2395, DOI 10.1681/ASN.V11122395
   Gayda M, 2012, CAN J CARDIOL, V28, P201, DOI 10.1016/j.cjca.2011.12.004
   Gibbons RJ, 2002, CIRCULATION, V106, P1883, DOI 10.1161/01.CIR.0000034670.06526.15
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Hevener AL, 2010, OBES REV, V11, P635, DOI 10.1111/j.1467-789X.2009.00691.x
   Huang PH, 2004, AM J CARDIOL, V93, P10, DOI 10.1016/j.amjcard.2003.09.004
   Ie EHY, 2006, NEPHROL DIAL TRANSPL, V21, P1474, DOI 10.1093/ndt/gfl167
   IMAI K, 1994, J AM COLL CARDIOL, V24, P1529, DOI 10.1016/0735-1097(94)90150-3
   Jae SY, 2008, ATHEROSCLEROSIS, V196, P256, DOI 10.1016/j.atherosclerosis.2006.10.023
   Jouven X, 2000, NEW ENGL J MED, V343, P826, DOI 10.1056/NEJM200009213431201
   Jouven X, 2005, NEW ENGL J MED, V352, P1951, DOI 10.1056/NEJMoa043012
   Kaya EB, 2009, TEX HEART I J, V36, P282
   Késöi I, 2010, NEPHROL DIAL TRANSPL, V25, P509, DOI 10.1093/ndt/gfp504
   Kiba T, 2004, PANCREAS, V29, pE51, DOI 10.1097/00006676-200408000-00019
   Kirkman DL, 2019, AM J PHYSIOL-RENAL, V316, pF898, DOI 10.1152/ajprenal.00539.2018
   Klein IHHT, 2003, J AM SOC NEPHROL, V14, P425, DOI 10.1097/01.ASN.0000045049.72965.B7
   Klein IHHT, 2001, J AM SOC NEPHROL, V12, P2427, DOI 10.1681/ASN.V12112427
   Lahiri MK, 2008, J AM COLL CARDIOL, V51, P1725, DOI 10.1016/j.jacc.2008.01.038
   Lauer Michael S, 2009, Cleve Clin J Med, V76 Suppl 2, pS18, DOI 10.3949/ccjm.76.s2.04
   do Prado DML, 2011, LUPUS, V20, P717, DOI 10.1177/0961203310397081
   Lipinski MJ, 2005, J CARD FAIL, V11, P624, DOI 10.1016/j.cardfail.2005.06.429
   McManus D, 2007, AM J KIDNEY DIS, V49, P365, DOI 10.1053/j.ajkd.2006.12.016
   Messias LR, 2011, ARQ BRAS CARDIOL, V96, P370, DOI 10.1590/S0066-782X2011005000044
   Mora S, 2003, JAMA-J AM MED ASSOC, V290, P1600, DOI 10.1001/jama.290.12.1600
   Myers J, 2002, NEW ENGL J MED, V346, P793, DOI 10.1056/NEJMoa011858
   Ozkayar N, 2015, HIPPOKRATIA, V19, P109
   Paisley KE, 2003, KIDNEY INT, V63, P624, DOI 10.1046/j.1523-1755.2003.00768.x
   Qiu SH, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.117.005505
   Shetler K, 2001, J AM COLL CARDIOL, V38, P1980, DOI 10.1016/S0735-1097(01)01652-7
   Shlipak MG, 2002, KIDNEY INT, V62, P997, DOI 10.1046/j.1523-1755.2002.00522.x
   Singh JP, 2000, AM J CARDIOL, V86, P309, DOI 10.1016/S0002-9149(00)00920-6
   Spies C, 2005, AM J CARDIOL, V95, P1175, DOI 10.1016/j.amjcard.2005.01.045
   Trimarchi H, 2021, NEPHROL DIAL TRANSPL, V36, P581, DOI 10.1093/ndt/gfz241
   Turgut D, 2020, TURK J NEPHROL, V29, P28, DOI 10.5152/turkjnephrol.2020.3633
   Vanholder R, 2005, NEPHROL DIAL TRANSPL, V20, P1048, DOI 10.1093/ndt/gfh813
   Vink EE, 2013, CURR HYPERTENS REP, V15, P95, DOI 10.1007/s11906-013-0328-5
   Vivekananthan DP, 2003, J AM COLL CARDIOL, V42, P831, DOI 10.1016/S0735-1097(03)00833-7
   von Känel R, 2009, J CARDIOL, V53, P248, DOI 10.1016/j.jjcc.2008.11.008
NR 50
TC 2
Z9 2
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2369
J9 BMC NEPHROL
JI BMC Nephrol.
PD NOV 23
PY 2021
VL 22
IS 1
AR 390
DI 10.1186/s12882-021-02596-4
PG 11
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA XB8PJ
UT WOS:000721584700001
PM 34809611
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Vareka, T
   Vecka, M
   Jirák, R
   Tvrzická, E
   Macásek, J
   Zák, A
   Zeman, M
AF Vareka, Tomas
   Vecka, Marek
   Jirak, Roman
   Tvrzicka, Eva
   Macasek, Jaroslav
   Zak, Ales
   Zeman, Miroslav
TI Plasma fatty acid profile in depressive disorder resembles insulin
   resistance state
SO NEUROENDOCRINOLOGY LETTERS
LA English
DT Article
DE fatty acids; depressive disorder; insulin resistance; delta-6-desaturase
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; OXIDATIVE STRESS
AB BACKGROUND: Depressive disorder is related to an increased risk of type 2 diabetes mellitus (DM2) and cardiovascular disease (CVD). Insulin resistance (IR), connected with altered fatty acid (FA) composition, namely with decreased proportion of polyunsaturated FA could participate in these associations. The aim of the study was to investigate the composition of FA in plasma cholesterol esters (CE) and phosphatidylcholine (PC) as well as indices of insulin resistance and oxidative stress in the patients with depressive disorder.
   MATERIALS AND METHODS: Parameters of lipid and glucose homeostasis, concentrations of FA in plasma cholesteryl esters (CE) and phosphatidylcholine (PC) and conjugated dienes in LDL were investigated in a group of 47 patients (9M/38F) with depression and compared with 47 control persons (16M/31F). Delta-9 desaturase (D9D) and D6D desaturase were estimated as product to precursor fatty acid ratios.
   RESULTS: In depressive patients increased concentrations of palmitoleic acid and total monounsaturated FA with decreased proportion of total polyunsaturated FA n-6 (PUFA n-6) (all p<0.05) in CE were found, while in PC increased proportion of saturated FA was observed (p<0.05). Moreover, index of D6D activity was significantly increased in PC and CE (p<0.05). Concomitantly, in depressive patients higher levels of plasma triacylglycerols (p<0.05), conjugated dienes in LDL (p<0.001) and HOMA index of IR (p<0.05) were found.
   CONCLUSIONS: Esterified FA composition of depressive patients revealed changes, similar to those, usually observed in insulin resistance. Dysregulation of FA could participate in the pathogenesis of depression and be associated with an increased risk of CVD and DM2.
C1 [Vareka, Tomas; Vecka, Marek; Tvrzicka, Eva; Macasek, Jaroslav; Zak, Ales; Zeman, Miroslav] Charles Univ Prague, Fac Med 1, Dept Internal Med 4, Prague 12808 2, Czech Republic.
   [Jirak, Roman] Charles Univ Prague, Fac Med 1, Dept Psychiat, Prague 12808 2, Czech Republic.
C3 Charles University Prague; Charles University Prague; General University
   Hospital Prague
RP Zeman, M (corresponding author), Charles Univ Prague, Fac Med 1, Dept Internal Med 4, U Nemocnice 2, Prague 12808 2, Czech Republic.
EM mirozem@seznam.cz
RI Vareka, Tomas/B-5246-2017; Vecka, Marek/A-3560-2008; Zak,
   Ales/G-8318-2016; Zeman, Miroslav/J-5281-2016; Macasek,
   Jaroslav/G-8337-2016; Tvrzicka, Eva/Q-6300-2016; Jirak,
   Roman/O-1658-2017
OI Vareka, Tomas/0000-0001-5390-8272; Vecka, Marek/0000-0002-3269-1817;
   Zak, Ales/0000-0002-1698-6068; Zeman, Miroslav/0000-0001-5338-603X;
   Macasek, Jaroslav/0000-0002-8009-8970; Tvrzicka,
   Eva/0000-0003-0794-8454; Jirak, Roman/0000-0002-8061-9668
FU IGA Ministry of Health, The Czech Republic [NT/13199]; Charles
   University in Prague, 1st Faculty of Medicine [PRVOUK-P25/LF1/2]
FX The study was supported by the grant NT/13199, IGA Ministry of Health,
   The Czech Republic and by the Research project of Charles University in
   Prague, 1st Faculty of Medicine - PRVOUK-P25/LF1/2.
CR Assies J, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010635
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   HIBBELN JR, 1995, AM J CLIN NUTR, V62, P1
   Kodydková J, 2009, CLIN BIOCHEM, V42, P1368, DOI 10.1016/j.clinbiochem.2009.06.006
   Kröger J, 2012, CURR OPIN LIPIDOL, V23, P4, DOI 10.1097/MOL.0b013e32834d2dc5
   Lindgärde F, 2006, AM J CLIN NUTR, V84, P1009, DOI 10.1093/ajcn/84.5.1009
   Liu YH, 2011, J PSYCHIATR RES, V45, P269, DOI 10.1016/j.jpsychires.2010.06.010
   Tsuboi H, 2012, CLIN NUTR
   ULBRICHT TLV, 1991, LANCET, V338, P985, DOI 10.1016/0140-6736(91)91846-M
   Wannamethee SG, 2005, ARCH INTERN MED, V165, P2644, DOI 10.1001/archinte.165.22.2644
   Warensjo E, 2007, THESIS UPPSALA U SWE
   Zák A, 2007, TOHOKU J EXP MED, V212, P359, DOI 10.1620/tjem.212.359
   Zeman M, 2009, NEUROENDOCRINOL LETT, V30, P387
NR 13
TC 12
Z9 12
U1 0
U2 7
PU MAGHIRA & MAAS PUBLICATIONS
PI MUNSBACH
PA MAGHIRA & MAAS S A R L, 6C, RUE GABRIEL LIPPMANN, L-5365 MUNSBACH,
   LUXEMBOURG
SN 0172-780X
EI 2354-4716
J9 NEUROENDOCRINOL LETT
JI Neuroendocrinol. Lett.
PY 2012
VL 33
SU 2
BP 83
EP 86
PG 4
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 052CN
UT WOS:000312175400016
PM 23183516
DA 2025-06-11
ER

PT J
AU Armon, G
   Shirom, A
   Berliner, S
   Shapira, I
   Melamed, S
AF Armon, Galit
   Shirom, Arie
   Berliner, Shlomo
   Shapira, Itzhak
   Melamed, Samuel
TI A prospective study of the association between obesity and burnout among
   apparently healthy men and women
SO JOURNAL OF OCCUPATIONAL HEALTH PSYCHOLOGY
LA English
DT Article
DE obesity; burnout; prospective design; gender difference; depression
ID BODY-MASS-INDEX; STRESS-INDUCED CORTISOL; 3RD NATIONAL-HEALTH;
   RISK-FACTORS; DEPRESSIVE SYMPTOMS; WAIST CIRCUMFERENCE; METABOLIC
   SYNDROME; VITAL EXHAUSTION; WEIGHT-GAIN; PSYCHOLOGICAL WORKLOAD
AB The authors prospectively tested the hypothesis that obesity predicts burnout and the reverse-causation hypothesis that burnout predicts obesity. Respondents were 724 men and 340 women, apparently healthy employees, who underwent routine periodic health examinations at 2 points of time about 18 months apart. Obesity was assessed by body mass index, waist-hip ratio, and waist circumference. In regression analyses, done separately for men and women, the authors controlled for depressive symptomatology, sport activity, and Time I levels of the criterion. The hypothesis that burnout predicts obesity was not supported. The authors found that Time I measures of obesity predicted reductions rather than the hypothesized elevations of Time 2 burnout levels. The authors also found that for male respondents with relatively higher levels of Time 1 burnout, the higher their level of Time I obesity measure, the lower their level of T2 burnout.
C1 [Armon, Galit; Shirom, Arie] Tel Aviv Univ, Fac Management, IL-69978 Tel Aviv, Israel.
   [Berliner, Shlomo; Shapira, Itzhak] Tel Aviv Sourasky Med Ctr, Tel Aviv, Israel.
   [Berliner, Shlomo; Shapira, Itzhak] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel.
   [Melamed, Samuel] Tel Aviv Univ, Sackler Fac Med, Dept Epidemiol & Prevent Med, IL-69978 Tel Aviv, Israel.
C3 Tel Aviv University; Tel Aviv University; Sackler Faculty of Medicine;
   Tel Aviv Sourasky Medical Center; Tel Aviv University; Sackler Faculty
   of Medicine; Tel Aviv University; Sackler Faculty of Medicine
RP Shirom, A (corresponding author), Tel Aviv Univ, Fac Management, Ramat Aviv,POB 39010, IL-69978 Tel Aviv, Israel.
EM ashirom@post.tau.ac.il
CR Agunis H, 2004, REGRESSION ANAL CATE
   Aiken K. S., 1991, MULTIPLE REGRESSION
   Andersen RE, 1998, JAMA-J AM MED ASSOC, V279, P938, DOI 10.1001/jama.279.12.938
   [Anonymous], 2003, Handbook of occupational health psychology, DOI [DOI 10.1037/10474-012, 10.1037/10474-012]
   APPELS A, 1993, J PSYCHOSOM RES, V37, P881, DOI 10.1016/0022-3999(93)90177-H
   APPELS A, 1988, EUR HEART J, V9, P758, DOI 10.1093/eurheartj/9.7.758
   Behn A, 2006, CURR OPIN CARDIOL, V21, P353, DOI 10.1097/01.hco.0000231406.84554.96
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   Brown ES, 2004, BIOL PSYCHIAT, V55, P1, DOI 10.1016/S0006-3223(03)00473-6
   Brown WJ, 1998, INT J OBESITY, V22, P520, DOI 10.1038/sj.ijo.0800617
   Carpenter KM, 2000, AM J PUBLIC HEALTH, V90, P251, DOI 10.2105/AJPH.90.2.251
   CREWS DJ, 1987, MED SCI SPORT EXER, V19, pS114
   CRISP AH, 1976, BRIT MED J, V1, P7, DOI 10.1136/bmj.1.6000.7
   Dallman MF, 2005, BRAIN BEHAV IMMUN, V19, P275, DOI 10.1016/j.bbi.2004.11.004
   Dallman MF, 2003, P NATL ACAD SCI USA, V100, P11696, DOI 10.1073/pnas.1934666100
   Davis JA, 1985, The logic of causal order
   De Vente W, 2003, OCCUP ENVIRON MED, V60, P54, DOI 10.1136/oem.60.suppl_1.i54
   Després JP, 2006, ANN MED, V38, P52, DOI 10.1080/07853890500383895
   Dietrich AJ, 2003, J AM BOARD FAM PRACT, V16, P107, DOI 10.3122/jabfm.16.2.107
   Douglas KM, 2004, PSYCHOSOM MED, V66, P679, DOI 10.1097/01.psy.0000138132.66332.85
   Epel EE, 1999, OBES RES, V7, P9, DOI 10.1002/j.1550-8528.1999.tb00385.x
   Epel ES, 2000, PSYCHOSOM MED, V62, P623, DOI 10.1097/00006842-200009000-00005
   Fabricatore AN, 2004, CLIN DERMATOL, V22, P332, DOI 10.1016/j.clindermatol.2004.01.006
   Faith MS, 2004, CURR OPIN PSYCHIATR, V17, P9, DOI 10.1097/00001504-200401000-00003
   Finkelstein EA, 2005, ANNU REV PUBL HEALTH, V26, P239, DOI 10.1146/annurev.publhealth.26.021304.144628
   Fogelholm M, 2006, INT J OBESITY, V30, P962, DOI 10.1038/sj.ijo.0803243
   Fogelholm M, 2000, Obes Rev, V1, P95, DOI 10.1046/j.1467-789x.2000.00016.x
   Glass DC, 1996, PSYCHOL HEALTH, V11, P23, DOI 10.1080/08870449608401975
   GREENO CG, 1994, PSYCHOL BULL, V115, P444, DOI 10.1037/0033-2909.115.3.444
   Hallman T, 2001, J CARDIOVASC RISK, V8, P39, DOI 10.1097/00043798-200102000-00006
   Hamer M, 2006, BIOL PSYCHOL, V71, P183, DOI 10.1016/j.biopsycho.2005.04.004
   Hampton T, 2006, JAMA-J AM MED ASSOC, V296, P1573, DOI 10.1001/jama.296.13.1573
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Hobfoll S. E., 2000, Handbook of organization behavior, P57, DOI DOI 10.1037/0003-066X.44.3.513
   HOBFOLL SE, 1989, AM PSYCHOL, V44, P513, DOI 10.1037/0003-066X.44.3.513
   Hobfoll SE., 1988, The ecology of stress, DOI DOI 10.1002/
   Jasienska G, 2005, WOMEN HEALTH ISS, V15, P145, DOI 10.1016/j.whi.2005.02.002
   *JOINT WHO FAO CON, 2003, DIET NUTR PREV CHR D
   Kivimäki M, 2006, INT J OBESITY, V30, P982, DOI 10.1038/sj.ijo.0803229
   Koertge JC, 2003, INT J BEHAV MED, V10, P44, DOI 10.1207/S15327558IJBM1001_04
   Kouvonen A, 2005, PSYCHOSOM MED, V67, P577, DOI 10.1097/01.psy.0000170330.08704.62
   Kress AM, 2006, J PSYCHOSOM RES, V60, P263, DOI 10.1016/j.jpsychores.2005.08.011
   Kronenberg F, 2000, ATHEROSCLEROSIS, V153, P433, DOI 10.1016/S0021-9150(00)00426-3
   Lallukka T, 2005, INT J OBESITY, V29, P909, DOI 10.1038/sj.ijo.0802962
   Lean MEJ, 2000, P NUTR SOC, V59, P331, DOI 10.1017/S0029665100000379
   Lim WJ, 2005, ARCH INTERN MED, V165, P910, DOI 10.1001/archinte.165.8.910
   Lubetkin EI, 2003, AM J PREV MED, V24, P354, DOI 10.1016/S0749-3797(03)00017-5
   Magnusson PKE, 2006, AM J EPIDEMIOL, V163, P1, DOI 10.1093/aje/kwj002
   Maier SF, 1998, PSYCHOL REV, V105, P83, DOI 10.1037/0033-295X.105.1.83
   McElroy SL, 2004, J CLIN PSYCHIAT, V65, P634
   MELAMED S, 1992, BEHAV MED, V18, P53, DOI 10.1080/08964289.1992.9935172
   MELAMED S, 2006, PSYCHOSOM MED, V86, P8763
   Melamed S., 2006, INT J STRESS MANAGE, V13, P176, DOI DOI 10.1037/1072-5245.13.2.176
   Melamed S, 2006, PSYCHOL BULL, V132, P327, DOI 10.1037/0033-2909.132.3.327
   Moch SL, 2003, ENDOCRINE, V21, P267, DOI 10.1385/ENDO:21:3:267
   Moyer A E, 1994, Obes Res, V2, P255
   Nease DE, 2003, J FAM PRACTICE, V52, P118
   Nemeroff CB, 1996, MOL PSYCHIATR, V1, P336
   Olshansky SJ, 2005, NEW ENGL J MED, V352, P1138, DOI 10.1056/NEJMsr043743
   Onyike CU, 2003, AM J EPIDEMIOL, V158, P1139, DOI 10.1093/aje/kwg275
   Ostry AS, 2006, BMC PUBLIC HEALTH, V6, DOI 10.1186/1471-2458-6-53
   Overgaard D, 2004, INT J OBESITY, V28, P1072, DOI 10.1038/sj.ijo.0802720
   Overgaard D, 2004, OCCUP MED-OXFORD, V54, P35, DOI 10.1093/occmed/kqg135
   Pecoraro N, 2004, ENDOCRINOLOGY, V145, P3754, DOI 10.1210/en.2004-0305
   Prescott E, 2003, INT J EPIDEMIOL, V32, P990, DOI 10.1093/ije/dyg235
   Puhl RM, 2006, OBESITY, V14, P1802, DOI 10.1038/oby.2006.208
   Roberts RE, 2002, ANN BEHAV MED, V24, P169, DOI 10.1207/S15324796ABM2403_02
   Rosenthal R., 2000, Contrasts and Effect Sizes in Behavioral Research: A Correlational Approach
   Rosmond R, 2004, MED HYPOTHESES, V62, P976, DOI 10.1016/j.mehy.2003.12.030
   Rosmond R, 2005, PSYCHONEUROENDOCRINO, V30, P1, DOI 10.1016/j.psyneuen.2004.05.007
   Schaufeli W., 1998, The burnout companion to study and practice: A critical analysis, V1st, DOI 10.1201/9781003062745
   Shen W, 2006, OBESITY, V14, P727, DOI 10.1038/oby.2006.83
   Shirom A, 1997, J Occup Health Psychol, V2, P275, DOI 10.1037/1076-8998.2.4.275
   Shirom A, 2006, J OCCUP HEALTH PSYCH, V11, P328, DOI 10.1037/1076-8998.11.4.328
   Shirom A, 2005, INT REV IND ORGAN PS, V20, P269
   Snijder MB, 2006, INT J EPIDEMIOL, V35, P83, DOI 10.1093/ije/dyi253
   SPITZER RL, 1994, JAMA-J AM MED ASSOC, V272, P1749, DOI 10.1001/jama.272.22.1749
   Spitzer RL, 1999, JAMA-J AM MED ASSOC, V282, P1737, DOI 10.1001/jama.282.18.1737
   Steptoe A, 2005, INT J OBESITY, V29, P1329, DOI 10.1038/sj.ijo.0803011
   Steptoe A, 2004, INT J OBESITY, V28, P1168, DOI 10.1038/sj.ijo.0802715
   Suls J, 2005, PSYCHOL BULL, V131, P260, DOI 10.1037/0033-2909.131.2.260
   Sundström J, 2006, BMJ-BRIT MED J, V332, P878, DOI 10.1136/bmj.38766.624097.1F
   Vgontzas AN, 1998, ARCH INTERN MED, V158, P1333, DOI 10.1001/archinte.158.12.1333
   Villareal DT, 2005, OBES RES, V13, P1849, DOI 10.1038/oby.2005.228
   Wallerius S, 2003, J ENDOCRINOL INVEST, V26, P616, DOI 10.1007/BF03347017
   Weinbrenner T, 2006, AM J CLIN NUTR, V83, P30
   *WHO, 2001, MENT HLTH NEW UNF NE
   Yusuf S, 2005, LANCET, V366, P1640, DOI 10.1016/S0140-6736(05)67663-5
   Zamboni M, 2005, INT J OBESITY, V29, P1011, DOI 10.1038/sj.ijo.0803005
NR 89
TC 33
Z9 40
U1 0
U2 19
PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA
SN 1076-8998
EI 1939-1307
J9 J OCCUP HEALTH PSYCH
JI J. Occup. Health Psychol.
PD JAN
PY 2008
VL 13
IS 1
BP 43
EP 57
DI 10.1037/1076-8998.13.1.43
PG 15
WC Public, Environmental & Occupational Health; Psychology, Applied
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Psychology
GA 254VI
UT WOS:000252615700005
PM 18211168
DA 2025-06-11
ER

PT J
AU Shi, ZM
   Tuomilehto, J
   Kronfeld-Schor, N
   Alberti, G
   Stern, N
   El-Osta, A
   Chai, ZL
   Bilu, C
   Einat, H
   Zimmet, P
AF Shi, Zumin
   Tuomilehto, Jaakko
   Kronfeld-Schor, Noga
   Alberti, George
   Stern, Naftali
   El-Osta, Assam
   Chai, Zhonglin
   Bilu, Carmel
   Einat, Haim
   Zimmet, Paul
TI The Circadian Syndrome Is a Significant and Stronger Predictor for
   Cardiovascular Disease than the Metabolic Syndrome-The NHANES Survey
   during 2005-2016
SO NUTRIENTS
LA English
DT Article
DE circadian syndrome; metabolic syndrome; cardiovascular disease; adults;
   NHANES
ID UNITED-STATES; SLEEP; PREVALENCE; CONSEQUENCES; MORTALITY; VALIDITY;
   GENETICS; RISK
AB The study aimed to compare the predictive value of the Circadian Syndrome (CircS) and Metabolic Syndrome (MetS) for cardiovascular disease (CVD). We used data of 12,156 adults aged >= 20 years who attended National Health and Nutrition Examination Survey (NHANES) 2005-2016. Mortality was obtained from the registry updated to 2019. The CircS was defined based on components of the MetS, in addition to short sleep and depression. Both the MetS and CircS were directly associated with self-reported history of CVD. The odds ratios for prevalent CVD associated with the CircS and MetS, respectively, were 2.92 (95% confidence interval (CI) 2.21-3.86) and 3.20 (2.38-4.30) in men, and 3.27 (2.34-4.59) and 3.04 (2.15-4.30) in women. The CircS had a better predictive power for prevalent CVD than that of MetS, as indicated by the higher positive predictive value (PPV); in men, the PPV for prevalent CVD with CircS was 23.1% and with MetS 20.9%, and in women these were 17.9% vs. 16.4%, respectively. However, the PPV of the CircS and MetS did not differ for the CVD mortality prediction. Women with CircS alone had a higher risk for both prevalent CVD and CVD mortality than those with MetS alone. In conclusion, the CircS is a significant and stronger predictor for CVD than the MetS in US adults.
C1 [Shi, Zumin] Qatar Univ, Coll Hlth Sci, Human Nutr Dept, QU Hlth, Doha 2713, Qatar.
   [Tuomilehto, Jaakko] Univ Helsinki, Dept Publ Hlth, Helsinki 00014, Finland.
   [Tuomilehto, Jaakko] Finnish Inst Hlth & Welf, Populat Hlth Unit, Helsinki 00280, Finland.
   [Tuomilehto, Jaakko] King Abdulaziz Univ, Saudi Diabet Res Grp, Jeddah 21589, Saudi Arabia.
   [Kronfeld-Schor, Noga; Bilu, Carmel] Tel Aviv Univ, Sch Zool, IL-6997801 Tel Aviv, Israel.
   [Alberti, George] Imperial Coll London, Dept Endocrinol & Metab, London SW7 2BX, England.
   [Stern, Naftali; Zimmet, Paul] Tel Aviv Med Ctr & Sch Med, Sagol Ctr Epigenet Aging & Metab, IL-6997801 Tel Aviv, Israel.
   [Stern, Naftali] Tel Aviv Univ, Sackler Fac Med, IL-6997801 Tel Aviv, Israel.
   [Stern, Naftali] Tel Aviv Univ, Sagol Sch Neurosci, IL-6997801 Tel Aviv, Israel.
   [El-Osta, Assam; Chai, Zhonglin; Zimmet, Paul] Monash Univ, Cent Clin Sch, Dept Diabet, Melbourne, Vic 3004, Australia.
   [El-Osta, Assam] Chinese Univ Hong Kong, Hong Kong Inst Diabet & Obes, Hong Kong, Peoples R China.
C3 Qatar University; University of Helsinki; King Abdulaziz University; Tel
   Aviv University; Imperial College London; Tel Aviv University; Sackler
   Faculty of Medicine; Tel Aviv University; Sackler Faculty of Medicine;
   Tel Aviv University; Monash University; Chinese University of Hong Kong
RP Shi, ZM (corresponding author), Qatar Univ, Coll Hlth Sci, Human Nutr Dept, QU Hlth, Doha 2713, Qatar.
EM zumin@qu.edu.qa
RI Shi, Zumin/A-1093-2009; CHAI, ZHONGLIN/X-1342-2019; Zimmet,
   Paul/H-7635-2013; tuomilehto, jaakko/E-6504-2011; Kronfeld-Schor,
   Noga/AAU-3792-2020
OI Chai, Zhonglin/0000-0001-8182-8579; El-Osta, Assam/0000-0001-7968-7375;
   Shi, Zumin/0000-0002-3099-3299; El-Osta, Assam/0000-0003-2969-9137;
   Kronfeld-Schor, Noga/0000-0002-5224-3341
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Allada R, 2021, NEW ENGL J MED, V384, P550, DOI 10.1056/NEJMra1802337
   Barr ELM, 2009, INTERN MED J, V39, P49, DOI 10.1111/j.1445-5994.2008.01864.x
   Cao YT, 2016, NUTRITION, V32, P970, DOI 10.1016/j.nut.2016.02.012
   Cao YT, 2016, NUTRIENTS, V8, DOI 10.3390/nu8040207
   Cho Y, 2015, CHRONOBIOL INT, V32, P1294, DOI 10.3109/07420528.2015.1073158
   Engstad T, 2000, STROKE, V31, P1602, DOI 10.1161/01.STR.31.7.1602
   Flemons WW, 1999, SLEEP, V22, P667, DOI 10.1093/sleep/22.5.667
   García MC, 2016, MMWR-MORBID MORTAL W, V65, P1245, DOI 10.15585/mmwr.mm6545a1
   Groop L, 2000, BRIT J NUTR, V83, pS39
   Hall JC, 2020, EUR HEART J, V41, P4535, DOI 10.1093/eurheartj/ehaa329
   Hall MH, 2018, AM PSYCHOL, V73, P994, DOI 10.1037/amp0000362
   Hare DL, 2014, EUR HEART J, V35, P1365, DOI 10.1093/eurheartj/eht462
   Heron Melonie, 2016, Natl Vital Stat Rep, V65, P1
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Hu G, 2004, ARCH INTERN MED, V164, P1066, DOI 10.1001/archinte.164.10.1066
   Huang TY, 2019, DIABETES CARE, V42, P1422, DOI 10.2337/dc19-0596
   Ikegami K, 2019, NAT REV ENDOCRINOL, V15, P590, DOI 10.1038/s41574-019-0237-z
   Johnson Clifford L, 2013, Vital Health Stat 2, P1
   Kantermann T, 2007, CURR BIOL, V17, P1996, DOI 10.1016/j.cub.2007.10.025
   Khan S, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.6616
   Knutson KL, 2007, SLEEP MED REV, V11, P163, DOI 10.1016/j.smrv.2007.01.002
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Le MH, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0173499
   Manfredini R, 2018, INTERN EMERG MED, V13, P641, DOI 10.1007/s11739-018-1900-4
   Maury E, 2010, CIRC RES, V106, P447, DOI 10.1161/CIRCRESAHA.109.208355
   Cruz MME, 2019, EUR J INTERN MED, V60, P1, DOI 10.1016/j.ejim.2019.01.001
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Ogden CL, 2018, MMWR-MORBID MORTAL W, V67, P186, DOI 10.15585/mmwr.mm6706a3
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Rodsutti J, 2004, SLEEP, V27, P694, DOI 10.1093/sleep/27.4.694
   Roth GA, 2020, J AM COLL CARDIOL, V76, P2982, DOI 10.1016/j.jacc.2020.11.010
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Scheer FAJL, 2009, P NATL ACAD SCI USA, V106, P4453, DOI 10.1073/pnas.0808180106
   Shi Z, 2021, J INTERN MED, V289, P851, DOI 10.1111/joim.13204
   Wang YL, 2022, FRONT NEUROL, V13, DOI 10.3389/fneur.2022.946172
   Xiong Y, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.715830
   Zimmet P, 2019, J INTERN MED, V286, P181, DOI 10.1111/joim.12924
NR 39
TC 19
Z9 20
U1 7
U2 26
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2022
VL 14
IS 24
AR 5317
DI 10.3390/nu14245317
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 7G7QN
UT WOS:000902713900001
PM 36558476
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Malkowska, P
AF Malkowska, Paulina
TI Positive Effects of Physical Activity on Insulin Signaling
SO CURRENT ISSUES IN MOLECULAR BIOLOGY
LA English
DT Review
DE physical activity; insulin sensitivity; metabolic health; inflammation;
   insulin signaling; exercise interventions; type 2 diabetes; metabolic
   syndrome
ID HORMONE-SENSITIVE LIPASE; BETA-CELL FUNCTION; STIMULATED GLUCOSE-UPTAKE;
   ACTIVATED PROTEIN-KINASE; SKELETAL-MUSCLE; ADIPOSE-TISSUE; METABOLIC
   SYNDROME; GLYCOGEN-SYNTHASE; TRANSCRIPTION FACTORS; RADICAL GENERATION
AB Physical activity is integral to metabolic health, particularly in addressing insulin resistance and related disorders such as type 2 diabetes mellitus (T2DM). Studies consistently demonstrate a strong association between physical activity levels and insulin sensitivity. Regular exercise interventions were shown to significantly improve glycemic control, highlighting exercise as a recommended therapeutic strategy for reducing insulin resistance. Physical inactivity is closely linked to islet cell insufficiency, exacerbating insulin resistance through various pathways including ER stress, mitochondrial dysfunction, oxidative stress, and inflammation. Conversely, physical training and exercise preserve and restore islet function, enhancing peripheral insulin sensitivity. Exercise interventions stimulate beta-cell proliferation through increased circulating levels of growth factors, further emphasizing its role in maintaining pancreatic health and glucose metabolism. Furthermore, sedentary lifestyles contribute to elevated oxidative stress levels and ceramide production, impairing insulin signaling and glucose metabolism. Regular exercise induces anti-inflammatory responses, enhances antioxidant defenses, and promotes mitochondrial function, thereby improving insulin sensitivity and metabolic efficiency. Encouraging individuals to adopt active lifestyles and engage in regular exercise is crucial for preventing and managing insulin resistance and related metabolic disorders, ultimately promoting overall health and well-being.
C1 [Malkowska, Paulina] Univ Szczecin, Inst Phys Culture Sci, PL-71065 Szczecin, Poland.
C3 University of Szczecin
RP Malkowska, P (corresponding author), Univ Szczecin, Inst Phys Culture Sci, PL-71065 Szczecin, Poland.
EM paulina.malkowska@usz.edu.pl
RI Niedźwiedzka-Rystwej, Paulina/T-6496-2019
OI Malkowska, Paulina/0000-0003-2430-5020
CR Adamopoulos S, 2001, EUR HEART J, V22, P791, DOI 10.1053/euhj.2000.2285
   Agius L, 2015, MOL ASPECTS MED, V46, P34, DOI 10.1016/j.mam.2015.09.002
   Ahmed B, 2021, BIOMED PHARMACOTHER, V137, DOI 10.1016/j.biopha.2021.111315
   Albert JS, 2014, NEW ENGL J MED, V370, P2307, DOI 10.1056/NEJMoa1315496
   Alghadir AH, 2016, INT J DIABETES DEV C, V36, P59, DOI 10.1007/s13410-015-0420-2
   Alibegovic AC, 2010, AM J PHYSIOL-ENDOC M, V299, pE752, DOI 10.1152/ajpendo.00590.2009
   Arkan MC, 2005, NAT MED, V11, P191, DOI 10.1038/nm1185
   Ashraf A, 2021, CURR DIABETES REV, V17, P198, DOI 10.2174/1573399816666200604122345
   Barseem NF, 2015, EGYPT PEDIATR ASSO, V63, P19, DOI 10.1016/j.epag.2014.12.001
   BEGUM N, 1995, J BIOL CHEM, V270, P709, DOI 10.1074/jbc.270.2.709
   Bejma J, 1999, J APPL PHYSIOL, V87, P465, DOI 10.1152/jappl.1999.87.1.465
   Belfiore A, 2017, ENDOCR REV, V38, P379, DOI 10.1210/er.2017-00073
   Belman JP, 2014, REV ENDOCR METAB DIS, V15, P55, DOI 10.1007/s11154-013-9276-2
   Benedetti MG, 2018, BIOMED RES INT, V2018, DOI 10.1155/2018/4840531
   Bergman BC, 2016, DIABETOLOGIA, V59, P785, DOI 10.1007/s00125-015-3850-y
   Bergouignan A, 2009, DIABETES, V58, P367, DOI 10.2337/db08-0263
   Besse-Patin Aurele, 2014, Int J Cell Biol, V2014, P519153, DOI 10.1155/2014/519153
   Bhatti JS, 2017, BBA-MOL BASIS DIS, V1863, P1066, DOI 10.1016/j.bbadis.2016.11.010
   Bienso RS, 2012, DIABETES, V61, P1090, DOI 10.2337/db11-0884
   Bilet L, 2020, DIABETOLOGIA, V63, P1211, DOI 10.1007/s00125-020-05128-1
   Bird Stephen R, 2016, BMJ Open Sport Exerc Med, V2, pe000143, DOI 10.1136/bmjsem-2016-000143
   Bloem CJ, 2008, J CLIN ENDOCR METAB, V93, P387, DOI 10.1210/jc.2007-1734
   Brady MJ, 2001, RECENT PROG HORM RES, V56, P157, DOI 10.1210/rp.56.1.157
   Brasaemle DL, 2007, J LIPID RES, V48, P2547, DOI 10.1194/jlr.R700014-JLR200
   Bugianesi E, 2005, HEPATOLOGY, V42, P987, DOI 10.1002/hep.20920
   Caliber M, 2021, CURR OPIN PHARMACOL, V58, P83, DOI 10.1016/j.coph.2021.04.002
   Carvalho MA, 2012, ENDOCRINOLOGY, V153, P5261, DOI 10.1210/en.2012-1400
   CASPERSEN CJ, 1985, PUBLIC HEALTH REP, V100, P126
   Cherrington AD, 1998, DIABETOLOGIA, V41, P987, DOI 10.1007/s001250051021
   Chibalin AV, 2000, P NATL ACAD SCI USA, V97, P38, DOI 10.1073/pnas.97.1.38
   Chistiakov DA, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/238463
   Chiu TT, 2011, CELL SIGNAL, V23, P1546, DOI 10.1016/j.cellsig.2011.05.022
   Choi YH, 2006, J CLIN INVEST, V116, P3240, DOI 10.1172/JCI24867
   Christakis MK, 2020, MENOPAUSE, V27, P999, DOI 10.1097/GME.0000000000001575
   Cohen P, 2001, NAT REV MOL CELL BIO, V2, P769, DOI 10.1038/35096075
   Conn VS, 2014, J PRIM CARE COMMUNIT, V5, P211, DOI 10.1177/2150131913520328
   Copps KD, 2012, DIABETOLOGIA, V55, P2565, DOI 10.1007/s00125-012-2644-8
   CROSS DAE, 1995, NATURE, V378, P785, DOI 10.1038/378785a0
   De Meyts P, 2008, TRENDS BIOCHEM SCI, V33, P376, DOI 10.1016/j.tibs.2008.06.003
   De Paoli M, 2021, AM J PATHOL, V191, P1490, DOI 10.1016/j.ajpath.2021.05.011
   Dela F, 2004, AM J PHYSIOL-ENDOC M, V287, pE1024, DOI 10.1152/ajpendo.00056.2004
   Delghingaro-Augusto V, 2012, AM J PHYSIOL-ENDOC M, V302, pE254, DOI 10.1152/ajpendo.00360.2011
   Delibegovic M, 2003, DIABETES, V52, P596, DOI 10.2337/diabetes.52.3.596
   Distefano G, 2018, J CACHEXIA SARCOPENI, V9, P279, DOI 10.1002/jcsm.12272
   Dong XC, 2008, CELL METAB, V8, P65, DOI 10.1016/j.cmet.2008.06.006
   Drew BG, 2015, J BIOL CHEM, V290, P5566, DOI 10.1074/jbc.M114.606459
   Eaton SB, 2017, RES Q EXERCISE SPORT, V88, P1, DOI 10.1080/02701367.2016.1268519
   Eberlé D, 2004, BIOCHIMIE, V86, P839, DOI 10.1016/j.biochi.2004.09.018
   Esposito K, 2003, JAMA-J AM MED ASSOC, V289, P1799, DOI 10.1001/jama.289.14.1799
   Febbraio MA, 2002, FASEB J, V16, P1335, DOI 10.1096/fj.01-0876rev
   Figueiredo PA, 2009, J GERONTOL A-BIOL, V64, P927, DOI 10.1093/gerona/glp066
   Geng YN, 2021, HEPATOL INT, V15, P21, DOI 10.1007/s12072-020-10121-2
   Gomes RM, 2013, CELL PHYSIOL BIOCHEM, V32, P310, DOI 10.1159/000354439
   Hales KG, 2004, MITOCHONDRION, V4, P285, DOI 10.1016/j.mito.2004.05.007
   Hall C, 2020, EXP MOL MED, V52, P911
   Han S, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-27182-y
   Hassan RH, 2016, J BIOL CHEM, V291, P3019, DOI 10.1074/jbc.M115.686949
   Hawley JA, 2004, DIABETES-METAB RES, V20, P383, DOI 10.1002/dmrr.505
   Hays NP, 2006, METABOLISM, V55, P525, DOI 10.1016/j.metabol.2005.11.005
   Heinonen S, 2017, DIABETOLOGIA, V60, P169, DOI 10.1007/s00125-016-4121-2
   Hilder TL, 2003, FEBS LETT, V553, P63, DOI 10.1016/S0014-5793(03)00972-4
   Hojbjerre L, 2011, DIABETES CARE, V34, P2265, DOI 10.2337/dc11-0631
   Holm C, 2003, BIOCHEM SOC T, V31, P1120, DOI 10.1042/BST0311120
   Horita S, 2016, BIOMED RES INT, V2016, DOI 10.1155/2016/5825170
   Horton JD, 2002, J CLIN INVEST, V109, P1125, DOI 10.1172/JCI200215593
   Hubbard SR, 2013, CSH PERSPECT BIOL, V5, DOI 10.1101/cshperspect.a008946
   Hudish LI, 2019, J CLIN INVEST, V129, P4001, DOI 10.1172/JCI129188
   James DE, 2021, NAT REV MOL CELL BIO, V22, P751, DOI 10.1038/s41580-021-00390-6
   Jaworski K, 2007, AM J PHYSIOL-GASTR L, V293, pG1, DOI 10.1152/ajpgi.00554.2006
   Jelenik T, 2017, DIABETES, V66, P2241, DOI 10.2337/db16-1147
   Jenkins NT, 2011, MED SCI SPORT EXER, V43, P2231, DOI 10.1249/MSS.0b013e318223b5f9
   Juan CA, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22094642
   Jurczak MJ, 2008, J CELL BIOCHEM, V104, P435, DOI 10.1002/jcb.21634
   Kahn SE, 2003, DIABETOLOGIA, V46, P3, DOI 10.1007/s00125-002-1009-0
   Kasuga M, 2006, J CLIN INVEST, V116, P1756, DOI 10.1172/JCI29189
   Kawai T, 2021, AM J PHYSIOL-CELL PH, V320, pC375, DOI 10.1152/ajpcell.00379.2020
   Kersten S, 2001, EMBO REP, V2, P282, DOI 10.1093/embo-reports/kve071
   Keshel Tyler E, 2015, J Obes Weight Loss Ther, V5
   Khalid M, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22168590
   Kolb H, 2022, BMC MED, V20, DOI 10.1186/s12916-022-02672-y
   Kosmas CE, 2023, J INT MED RES, V51, DOI 10.1177/03000605231164548
   Kozakiewicz M, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/5123628
   Krycer JR, 2010, TRENDS ENDOCRIN MET, V21, P268, DOI 10.1016/j.tem.2010.01.001
   Kumar AS, 2019, ANN PHYS REHABIL MED, V62, P98, DOI 10.1016/j.rehab.2018.11.001
   Kwon OS, 2015, AM J PHYSIOL-ENDOC M, V309, pE11, DOI 10.1152/ajpendo.00124.2015
   Langlet F, 2017, CELL, V171, P824, DOI 10.1016/j.cell.2017.09.045
   Lee SF, 2015, INT J CLIN PRACT, V69, P1159, DOI 10.1111/ijcp.12679
   Lee SH, 2022, DIABETES METAB J, V46, P15, DOI 10.4093/dmj.2021.0280
   Lee S, 2019, DIABETOLOGIA, V62, P1048, DOI 10.1007/s00125-019-4866-5
   Lee-Odegård S, 2022, METABOLITES, V12, DOI 10.3390/metabo12030208
   Leeuwenburgh C, 1997, AM J PHYSIOL-REG I, V272, pR363, DOI 10.1152/ajpregu.1997.272.1.R363
   Leeuwenburgh C, 1999, FREE RADICAL BIO MED, V27, P186, DOI 10.1016/S0891-5849(99)00071-4
   LEEUWENBURGH C, 1994, AM J PHYSIOL, V267, pR439, DOI 10.1152/ajpregu.1994.267.2.R439
   Leto D, 2012, NAT REV MOL CELL BIO, V13, P383, DOI 10.1038/nrm3351
   Li SJ, 2010, P NATL ACAD SCI USA, V107, P3441, DOI 10.1073/pnas.0914798107
   Li YC, 2014, PHYSIOL REP, V2, DOI 10.14814/phy2.12187
   Lipke K, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11050844
   London A, 2021, J CLIN MED, V10, DOI 10.3390/jcm10030390
   Malkowska P, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms241311156
   Marcinkiewicz A, 2006, J BIOL CHEM, V281, P11901, DOI 10.1074/jbc.M600171200
   Masenga SK, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24097898
   Merz KE, 2020, COMPR PHYSIOL, V10, P785, DOI 10.1002/cphy.c190029
   Morigny P, 2016, BIOCHIMIE, V125, P259, DOI 10.1016/j.biochi.2015.10.024
   Narendran P, 2015, DIABETOLOGIA, V58, P10, DOI 10.1007/s00125-014-3412-8
   Newgard CB, 2000, DIABETES, V49, P1967, DOI 10.2337/diabetes.49.12.1967
   Niemann MJ, 2020, J DIABETES RES, V2020, DOI 10.1155/2020/7694825
   Nystoriak Matthew A, 2018, Front Cardiovasc Med, V5, P135, DOI 10.3389/fcvm.2018.00135
   Park SS, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21061949
   Perreault L, 2018, JCI INSIGHT, V3, DOI 10.1172/jci.insight.96805
   Perry RJ, 2015, CELL, V160, P745, DOI 10.1016/j.cell.2015.01.012
   Petersen MC, 2018, PHYSIOL REV, V98, P2133, DOI 10.1152/physrev.00063.2017
   Phillips CM, 2017, INT J BEHAV NUTR PHY, V14, DOI 10.1186/s12966-017-0594-8
   Pinckard K, 2019, FRONT CARDIOVASC MED, V6, DOI 10.3389/fcvm.2019.00069
   Pizzino G, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/8416763
   de Almeida AJPO, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/1225578
   POWERS SK, 1993, AM J PHYSIOL, V265, pH2094, DOI 10.1152/ajpheart.1993.265.6.H2094
   Powers SK, 1999, MED SCI SPORT EXER, V31, P987, DOI 10.1097/00005768-199907000-00011
   Pu D, 2017, CLIMACTERIC, V20, P583, DOI 10.1080/13697137.2017.1386649
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Rebrin K, 1996, J CLIN INVEST, V98, P741, DOI 10.1172/JCI118846
   Regensteiner JG, 2015, MED SCI SPORT EXER, V47, P58, DOI 10.1249/MSS.0000000000000371
   Rehman D., 2019, Sex Differences in Exercise Response in Type 2 Diabetes
   Reidy PT, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21041514
   Reidy PT, 2018, J PHYSIOL-LONDON, V596, P5217, DOI 10.1113/JP276798
   Resjö S, 2002, CELL SIGNAL, V14, P231, DOI 10.1016/S0898-6568(01)00238-8
   Rieusset J, 1999, DIABETES, V48, P699, DOI 10.2337/diabetes.48.4.699
   Rivers SL, 2019, ENDOCRINOLOGY, V160, P1021, DOI 10.1210/en.2018-01061
   Roden M, 2019, NATURE, V576, P51, DOI 10.1038/s41586-019-1797-8
   Ros S, 2009, J BIOL CHEM, V284, P6370, DOI 10.1074/jbc.M808576200
   Saltiel AR, 2001, NATURE, V414, P799, DOI 10.1038/414799a
   Schenk S, 2008, J CLIN INVEST, V118, P2992, DOI 10.1172/JCI34260
   Schmitz-Peiffer C, 2008, DIABETES, V57, P1774, DOI 10.2337/db07-1769
   Schuch FB, 2021, TRENDS PSYCHIATR PSY, V43, P177
   Sergi D, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00532
   Shamsuzzaman ASM, 2004, CIRCULATION, V109, P2181, DOI 10.1161/01.CIR.0000127960.28627.75
   Slentz CA, 2009, DIABETES CARE, V32, P1807, DOI 10.2337/dc09-0032
   Snel M, 2012, INT J ENDOCRINOL, V2012, DOI 10.1155/2012/983814
   Stefan N, 2002, HORM METAB RES, V34, P469, DOI 10.1055/s-2002-34785
   STRALFORS P, 1989, EUR J BIOCHEM, V182, P379, DOI 10.1111/j.1432-1033.1989.tb14842.x
   Sung KC, 2018, ATHEROSCLEROSIS, V275, P50, DOI 10.1016/j.atherosclerosis.2018.05.042
   Suzuki K, 2002, EXERC IMMUNOL REV, V8, P6
   Suzuki Y, 2001, MOL CELL BIOL, V21, P2683, DOI 10.1128/MCB.21.8.2683-2694.2001
   Sylow L, 2014, CELL SIGNAL, V26, P323, DOI 10.1016/j.cellsig.2013.11.007
   Sylow L, 2013, DIABETES, V62, P1865, DOI 10.2337/db12-1148
   Sztalryd C, 2003, J CELL BIOL, V161, P1093, DOI 10.1083/jcb.200210169
   Tzivion G, 2011, BBA-MOL CELL RES, V1813, P1938, DOI 10.1016/j.bbamcr.2011.06.002
   Ueda S, 2010, FASEB J, V24, P2254, DOI 10.1096/fj.09-137380
   Virtanen KA, 2002, J CLIN ENDOCR METAB, V87, P3902, DOI 10.1210/jc.87.8.3902
   Wen Y, 2022, DIABETES RES CLIN PR, V187, DOI 10.1016/j.diabres.2022.109860
   Yan HY, 2024, BIOMOLECULES, V14, DOI 10.3390/biom14020243
   Yang A, 2020, BIOCHEM J, V477, P985, DOI 10.1042/BCJ20190468
   Yaribeygi H, 2021, J DIABETES RES, V2021, DOI 10.1155/2021/3331865
   Yaribeygi H, 2019, J CELL PHYSIOL, V234, P12385, DOI 10.1002/jcp.28066
   Yoon H, 2021, MOL CELL, V81, P3708, DOI 10.1016/j.molcel.2021.08.027
   Youle RJ, 2012, SCIENCE, V337, P1062, DOI 10.1126/science.1219855
   Youngren JF, 2007, CELL MOL LIFE SCI, V64, P873, DOI 10.1007/s00018-007-6359-9
   Yung JHM, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9030706
   Zarotsky V, 2014, ANDROLOGY-US, V2, P819, DOI 10.1111/andr.274
   Zechner R, 2015, EMBO MOL MED, V7, P359, DOI 10.15252/emmm.201404846
   Zhao XF, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1149239
   Zhou ZQ, 2020, SCI TRANSL MED, V12, DOI 10.1126/scitranslmed.aax8096
NR 161
TC 14
Z9 14
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1467-3037
EI 1467-3045
J9 CURR ISSUES MOL BIOL
JI Curr. Issues Mol. Biol.
PD JUN
PY 2024
VL 46
IS 6
BP 5467
EP 5487
DI 10.3390/cimb46060327
PG 21
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA WJ1V3
UT WOS:001254421000001
PM 38920999
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Uçkan, K
   Demir, H
   Turan, K
   Sarikaya, E
   Demir, C
AF Uckan, Kazim
   Demir, Halit
   Turan, Kasim
   Sarikaya, Eren
   Demir, Canan
TI Role of Oxidative Stress in Obese and Nonobese PCOS Patients
SO INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
LA English
DT Article
ID POLYCYSTIC-OVARY-SYNDROME; INSULIN-RESISTANCE; ENDOTHELIAL DYSFUNCTION;
   WOMEN; RISK; YOUNG; MALONDIALDEHYDE; ANTIOXIDANTS; PREVALENCE; CONSENSUS
AB Objective. The aim of this study was to evaluate the relationship between the oxidant-antioxidant status, endothelial dysfunction, lipid metabolism, and metabolic syndrome risk in women with polycystic ovary syndrome (PCOS). Materials and Methods. Forty-five obese (BMI > 30 kg/m2) woman diagnosed with PCOS in the study, forty-five nonobese (BMI < 30 kg/m(2)) PCOS diagnosis working groups, and forty-nine healthy control groups were created with patients. Serum malondialdehyde (MDA) levels with antioxidant activities, such as SOD, GSH, GPx, and CAT activities, were measured by spectrophotometry. Results. There was a statistically significant difference in the mean serum MDA level in the obese PCOS group compared to the nonobese group and the control group (p < 0.001). When the antioxidant parameters, such as SOD, GPx, GSH, and CAT, were compared with the healthy control group, nonobese, and obese PCOS groups, the difference between the groups was statistically significant (p < 0.001). A positive correlation was observed between MDA and BMI, triglyceride, LDL, SBP, DBP, and HOMA-IR in the PCOS patient group. Conclusion. Oxidative stress and decreased antioxidant parameters in PCOS patients were correlated with hyperinsulinemia, hypertension, and dyslipidemia findings, and we think that this oxidative stress condition may contribute to metabolic syndrome and cardiovascular diseases in PCOS patients.
C1 [Uckan, Kazim] Van Training & Res Hosp, Dept Obstet & Gynecol, Van, Turkey.
   [Demir, Halit] Van Yuzuncu Yil Univ, Dept Biochem, Van, Turkey.
   [Turan, Kasim; Sarikaya, Eren] Clin Obstet & Gynecol Dr KasimTuran, Van, Turkey.
   [Demir, Canan] Van Yuzuncu Yil Univ, Vocat Sch Hlth Serv, Van, Turkey.
C3 Van Training & Research Hospital; Yuzuncu Yil University; Yuzuncu Yil
   University
RP Uçkan, K (corresponding author), Van Training & Res Hosp, Dept Obstet & Gynecol, Van, Turkey.
EM druckan65@hotmail.com
RI DEMIR, Canan/GWM-8855-2022; Sarikaya, Eren/GWZ-7526-2022
OI DEMIR, Canan/0000-0002-4204-9756; Sarikaya, Eren/0000-0002-5644-0713
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Amini L, 2015, INT J REPROD BIOMED, V13, P1
   Baptiste CG, 2010, J STEROID BIOCHEM, V122, P42, DOI 10.1016/j.jsbmb.2009.12.010
   Blair SA, 2013, J REPROD MED, V58, P107
   Blank SK, 2007, SEMIN REPROD MED, V25, P352, DOI 10.1055/s-2007-984741
   Calderon-Margalit R, 2014, ARTERIOSCL THROM VAS, V34, P2688, DOI 10.1161/ATVBAHA.114.304136
   Chang J, 2004, FERTIL STERIL, V81, P19, DOI 10.1016/j.fertnstert.2003.10.004
   Christy NA, 2005, ANN PHARMACOTHER, V39, P1517, DOI 10.1345/aph.1G025
   Desai V, 2014, J CLIN DIAGN RES, V8, pCC1, DOI 10.7860/JCDR/2014/8125.4530
   Enechukwu Chukwunonso Isaiah, 2019, Obstet Gynecol Sci, V62, P335
   Fauser BCJM, 2012, FERTIL STERIL, V97, P28, DOI 10.1016/j.fertnstert.2011.09.024
   Fenkci V, 2003, FERTIL STERIL, V80, P123, DOI 10.1016/S0015-0282(03)00571-5
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Glintborg D, 2015, EUR J ENDOCRINOL, V172, P627, DOI 10.1530/EJE-14-1108
   González F, 2006, J CLIN ENDOCR METAB, V91, P336, DOI 10.1210/jc.2005-1696
   Góth L, 2000, LANCET, V356, P1820, DOI 10.1016/S0140-6736(00)03238-4
   Hsueh AJW, 2015, ENDOCR REV, V36, P1, DOI 10.1210/er.2014-1020
   Jung HH, 2004, AM J NEPHROL, V24, P537, DOI 10.1159/000081731
   Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213
   Kuhl H, 2005, CLIMACTERIC, V8, P3, DOI 10.1080/13697130500148875
   Kurdoglu Z, 2012, J ENDOCRINOL INVEST, V35, P317, DOI 10.3275/7682
   Kusçu NK, 2009, ACTA OBSTET GYN SCAN, V88, P612, DOI 10.1080/00016340902859315
   Ladson G, 2011, FERTIL STERIL, V95, P1059, DOI 10.1016/j.fertnstert.2010.12.002
   Lamos EM, 2017, EXPERT REV CLIN PHAR, V10, P401, DOI 10.1080/17512433.2017.1292125
   Lee JY, 2010, CURR WOMENS HEALTH R, V6, P96, DOI 10.2174/157340410791321336
   Legro RS, 2016, BEST PRACT RES CL OB, V37, P152, DOI 10.1016/j.bpobgyn.2016.08.001
   Liu SH, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011302
   Lord J, 2004, CURR OPIN OBSTET GYN, V16, P481, DOI 10.1097/00001703-200412000-00008
   Luque-Ramírez M, 2015, EXPERT OPIN THER TAR, V19, P1545, DOI 10.1517/14728222.2015.1075511
   Meldrum DR, 2017, FERTIL STERIL, V107, DOI 10.1016/j.fertnstert.2017.02.110
   Mohan S. K., 2009, Biology and Medicine, V1, P44
   Moran C, 2010, GYNECOL OBSTET INVES, V69, P274, DOI 10.1159/000277640
   Oakley AE, 2009, ENDOCR REV, V30, P713, DOI 10.1210/er.2009-0005
   Piao MJ, 2011, TOXICOL LETT, V201, P92, DOI 10.1016/j.toxlet.2010.12.010
   Sabuncu T, 2001, CLIN BIOCHEM, V34, P407, DOI 10.1016/S0009-9120(01)00245-4
   Savic-Radojevic A, 2015, HORM-INT J ENDOCRINO, V14, P101, DOI 10.14310/horm.2002.1525
   Seghinsara AM, 2019, CELL J, V21, P210, DOI 10.22074/cellj.2019.5733
   Senoner T, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092090
   Shi YH, 2014, EUR J OBSTET GYN R B, V173, P66, DOI 10.1016/j.ejogrb.2013.11.011
   Shokoohi M., 2019, Asian Pacific Journal of Reproduction, V8, P148, DOI 10.4103/2305-0500.262831
   Sitruk-Ware R, 2013, BEST PRACT RES CL EN, V27, P13, DOI 10.1016/j.beem.2012.09.004
   Takeda Eiji, 2005, J Med Invest, V52 Suppl, P259, DOI 10.2152/jmi.52.259
   Tehrani FR, 2014, REPROD BIOL ENDOCRIN, V12, DOI 10.1186/1477-7827-12-89
   Tsilchorozidou T, 2004, CLIN ENDOCRINOL, V60, P1, DOI 10.1046/j.1365-2265.2003.01842.x
   Tsutsumi R, 2009, ENDOCR J, V56, P729, DOI 10.1507/endocrj.K09E-185
   Turan V, 2015, J PEDIATR ADOL GYNEC, V28, P119, DOI 10.1016/j.jpag.2014.05.003
   Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
   Victor VM, 2009, J CLIN ENDOCR METAB, V94, P3505, DOI 10.1210/jc.2009-0466
   Wang HF, 2011, AFR J BIOTECHNOL, V10, P9213
   Wang HS, 2019, ARCH GYNECOL OBSTET, V300, P1413, DOI 10.1007/s00404-019-05305-7
   WHO, 2011, WORLD REPORT ON DISABILITY, P1
   Yildiz BO, 2015, J CLIN ENDOCR METAB, V100, P794, DOI 10.1210/jc.2014-3196
   Zhang JX, 2012, HUM REPROD, V27, P2484, DOI 10.1093/humrep/des191
NR 53
TC 49
Z9 51
U1 3
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-5031
EI 1742-1241
J9 INT J CLIN PRACT
JI Int. J. Clin. Pract.
PD FEB 9
PY 2022
VL 2022
AR 4579831
DI 10.1155/2022/4579831
PG 9
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA 0B8UD
UT WOS:000774902200001
PM 35685525
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Page, S
   Chandhoke, V
   Baranova, A
AF Page, S.
   Chandhoke, V.
   Baranova, A.
TI Melanin and melanogenesis in adipose tissue: possible mechanisms for
   abating oxidative stress and inflammation?
SO OBESITY REVIEWS
LA English
DT Review
DE Melanin; metabolic syndrome; inflammation; obesity
ID MELANOCYTE-STIMULATING HORMONE; GENE-ENVIRONMENT INTERACTION;
   ELECTRON-SPIN-RESONANCE; FATTY LIVER-DISEASE; ALPHA-MSH; METABOLIC
   SYNDROME; INSULIN-RESISTANCE; MELANOCORTIN-1 RECEPTOR;
   PLASMA-CONCENTRATIONS; SYNTHETIC MELANINS
AB P>Obesity has become a worldwide epidemic and can lead to multiple chronic diseases. Adipose tissue is increasingly thought to play an active role in obesity-related pathologies such as insulin resistance and non-alcoholic fatty liver disease. Obesity has been strongly associated with systemic inflammation and, to a lesser degree, with oxidative stress, although the causal relationships among these factors are unclear. A recent study demonstrating an expression of the components of the melanogenic pathway and the presence of melanin in visceral adipose has raised questions regarding the possible role of melanogenesis in adipose tissue. As this study also found larger amounts of melanin in the adipose tissue of obese patients relative to lean ones, we hypothesize that melanin, a pigment known for its antioxidant and anti-inflammatory properties, may scavenge reactive oxygen species and abate oxidative stress and inflammation in adipose tissue. This review considers the evidence to support such a hypothesis, and speculates on the role of melanin within adipocytes. Furthermore, we consider whether the alpha-melanocyte-stimulating hormone or its synthetic analogues could be used to stimulate melanin production in adipocytes, should the hypothesis be supported in future experiments.
C1 [Page, S.; Chandhoke, V.; Baranova, A.] George Mason Univ, Dept Mol & Microbiol, Coll Sci, Fairfax, VA 22030 USA.
   [Page, S.; Baranova, A.] Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA USA.
C3 George Mason University; Inova Fairfax Hospital
RP Baranova, A (corresponding author), George Mason Univ, Dept Mol & Microbiol, Coll Sci, David King Hall,MSN 3E1, Fairfax, VA 22030 USA.
EM abaranov@gmu.edu
RI Baranova, Ancha/B-4608-2012
OI Baranova, Ancha/0000-0001-6810-5982
CR Andreassi MG, 2009, MUTAT RES-FUND MOL M, V667, P35, DOI 10.1016/j.mrfmmm.2008.10.018
   [Anonymous], 2009, Obesity and Overweight
   Bergamini CM, 2004, CURR PHARM DESIGN, V10, P1611, DOI 10.2174/1381612043384664
   Bhardwaj RS, 1996, J IMMUNOL, V156, P2517
   BLUHER M, 2009, CURR OPIN LIPIDOL
   Böhm M, 2005, J BIOL CHEM, V280, P5795, DOI 10.1074/jbc.M406334200
   Böhm M, 2002, J INVEST DERMATOL, V118, P533, DOI 10.1046/j.0022-202x.2001.01704.x
   Brzoska T, 1999, ANN NY ACAD SCI, V885, P230
   Brzoska T, 2008, ENDOCR REV, V29, P581, DOI 10.1210/er.2007-0027
   Buscà R, 2000, PIGM CELL RES, V13, P60, DOI 10.1034/j.1600-0749.2000.130203.x
   BUSTAMANTE J, 1993, PIGM CELL RES, V6, P348, DOI 10.1111/j.1600-0749.1993.tb00612.x
   Caballería L, 2008, BMC GASTROENTEROL, V8, DOI 10.1186/1471-230X-8-44
   Cardones AR, 2009, ARCH DERMATOL, V145, P441, DOI 10.1001/archdermatol.2008.623
   Chen R, 2007, J BIOL CHEM, V282, P24842, DOI 10.1074/jbc.M702865200
   Colombo G, 2002, NEUROIMMUNOMODULAT, V10, P208, DOI 10.1159/000068323
   Coyne T, 2009, BRIT J NUTR, V102, P1668, DOI 10.1017/S000711450999081X
   de Luca C, 2008, FEBS LETT, V582, P97, DOI 10.1016/j.febslet.2007.11.057
   DIGIROLAMO M, 1975, AM J PHYSIOL, V229, P107, DOI 10.1152/ajplegacy.1975.229.1.107
   Donahoo WT, 2009, METABOLISM, V58, P16, DOI 10.1016/j.metabol.2008.07.028
   EZZAHIR A, 1989, J PHOTOCH PHOTOBIO B, V3, P341, DOI 10.1016/1011-1344(89)80038-7
   Fain JN, 2008, METABOLISM, V57, P1005, DOI 10.1016/j.metabol.2008.02.019
   Fain JN, 2006, VITAM HORM, V74, P443, DOI 10.1016/S0083-6729(06)74018-3
   Fujita K, 2006, CIRC J, V70, P1437, DOI 10.1253/circj.70.1437
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gavrila A, 2005, J CLIN ENDOCR METAB, V90, P1047, DOI 10.1210/jc.2004-1124
   Getting SJ, 2002, ARTHRITIS RHEUM, V46, P2765, DOI 10.1002/art.10526
   Glassford AJ, 2007, AM J PHYSIOL-ENDOC M, V293, pE1590, DOI 10.1152/ajpendo.00490.2007
   Gonindard C, 1996, PIGM CELL RES, V9, P148, DOI 10.1111/j.1600-0749.1996.tb00103.x
   Greenfield JR, 2009, NEW ENGL J MED, V360, P44, DOI 10.1056/NEJMoa0803085
   Guzy RD, 2005, CELL METAB, V1, P401, DOI 10.1016/j.cmet.2005.05.001
   Hadley ME, 2006, PEPTIDES, V27, P921, DOI 10.1016/j.peptides.2005.01.029
   Hagiwara S, 2009, METABOLISM, V58, P934, DOI 10.1016/j.metabol.2009.02.033
   Hallschmid M, 2004, PHYSIOL BEHAV, V83, P55, DOI 10.1016/j.physbeh.2004.07.023
   Herrling T, 2008, SPECTROCHIM ACTA A, V69, P1429, DOI 10.1016/j.saa.2007.09.030
   Hill RP, 2005, PEPTIDES, V26, P1150, DOI 10.1016/j.peptides.2005.01.019
   Hoch M, 2007, OBESITY, V15, P40, DOI 10.1038/oby.2007.525
   Hoggard N, 2004, CLIN ENDOCRINOL, V61, P31, DOI 10.1111/j.1365-2265.2004.02056.x
   Ito S, 2003, PIGM CELL RES, V16, P523, DOI 10.1034/j.1600-0749.2003.00072.x
   ITO S, 1989, Journal of Investigative Dermatology, V92, p261S, DOI 10.1111/1523-1747.ep13076587
   Jahovic N, 2004, PEPTIDES, V25, P129, DOI 10.1016/j.peptides.2003.11.008
   Jarrar MH, 2008, ALIMENT PHARM THER, V27, P412, DOI 10.1111/j.1365-2036.2007.03586.x
   Jo SK, 2001, J KOREAN MED SCI, V16, P603, DOI 10.3346/jkms.2001.16.5.603
   Kabon B, 2004, ANESTHESIOLOGY, V100, P274, DOI 10.1097/00000542-200402000-00015
   Karalis KP, 2009, FEBS J, V276, P5747, DOI 10.1111/j.1742-4658.2009.07304.x
   Katsuki A, 2000, INT J OBESITY, V24, P1260, DOI 10.1038/sj.ijo.0801400
   Kobayashi N, 1998, J INVEST DERMATOL, V110, P806, DOI 10.1046/j.1523-1747.1998.00178.x
   KOKOT A, 2008, EXP DERMATOL, V17, P286
   KORYTOWSKI W, 1986, BIOCHIM BIOPHYS ACTA, V882, P145, DOI 10.1016/0304-4165(86)90149-2
   Krol ES, 1998, CHEM RES TOXICOL, V11, P1434, DOI 10.1021/tx980114c
   Lee SY, 2004, TRANSPLANTATION, V78, P1756, DOI 10.1097/01.TP.0000144332.44435.AB
   Li CL, 2006, AM J PHYSIOL-RENAL, V290, pF384, DOI 10.1152/ajprenal.00282.2004
   LIPTON JM, 1994, ANN NY ACAD SCI, V741, P137, DOI 10.1111/j.1749-6632.1994.tb23095.x
   LUGER TA, 1993, ANN NY ACAD SCI, V680, P567, DOI 10.1111/j.1749-6632.1993.tb19741.x
   Manna SX, 2006, EUR J IMMUNOL, V36, P754, DOI 10.1002/eji.200535209
   Mohagheghpour N, 2000, CELL IMMUNOL, V199, P25, DOI 10.1006/cimm.1999.1599
   MONTAGNA W, 1991, J AM ACAD DERMATOL, V24, P929, DOI 10.1016/0190-9622(91)70148-U
   Morandini R, 1998, J CELL PHYSIOL, V175, P276, DOI 10.1002/(SICI)1097-4652(199806)175:3<276::AID-JCP5>3.0.CO;2-L
   MORELLI JG, 1993, J INVEST DERMATOL, V100, pS191
   MURPHY MT, 1983, SCIENCE, V221, P192, DOI 10.1126/science.6602381
   Nakamuta M, 2008, INT J MOL MED, V22, P663, DOI 10.3892/ijmm_00000070
   Nam SY, 2001, J CLIN ENDOCR METAB, V86, P4849, DOI 10.1210/jc.86.10.4849
   Nathan C, 2008, MOL MED, V14, P485, DOI 10.2119/2008-00038.Nathan
   Nishida T, 2004, INT IMMUNOPHARMACOL, V4, P1059, DOI 10.1016/j.intimp.2004.04.011
   Nofsinger JB, 2002, FREE RADICAL BIO MED, V32, P720, DOI 10.1016/S0891-5849(02)00763-3
   O'Rourke RW, 2009, SURGERY, V145, P255, DOI 10.1016/j.surg.2008.08.038
   Ogden CL, 2006, JAMA-J AM MED ASSOC, V295, P1549, DOI 10.1001/jama.295.13.1549
   Oktar BK, 2004, PROSTAG LEUKOTR ESS, V71, P1, DOI 10.1016/j.plefa.2003.11.009
   Park HY, 2009, CELL MOL LIFE SCI, V66, P1493, DOI 10.1007/s00018-009-8703-8
   POREBSKABUDNY M, 1992, BIOCHIM BIOPHYS ACTA, V1116, P11, DOI 10.1016/0304-4165(92)90121-A
   Prota G., 1992, Melanins and melanogenesis
   Qi L, 2008, NUTR REV, V66, P684, DOI 10.1111/j.1753-4887.2008.00128.x
   Raap U, 2003, J IMMUNOL, V171, P353, DOI 10.4049/jimmunol.171.1.353
   Rajora N, 1997, J NEUROSCI, V17, P2181
   Randhawa M, 2009, FASEB J, V23, P835, DOI 10.1096/fj.08-116327
   Rivera L, 2009, BIOCHEM PHARMACOL, V77, P1053, DOI 10.1016/j.bcp.2008.11.027
   Romao I, 2008, J AM DIET ASSOC, V108, pS24, DOI 10.1016/j.jada.2008.01.022
   Rózanowska M, 1999, FREE RADICAL BIO MED, V26, P518, DOI 10.1016/S0891-5849(98)00234-2
   SARNA T, 1985, PHOTOCHEM PHOTOBIOL, V42, P529, DOI 10.1111/j.1751-1097.1985.tb01605.x
   SARNA T, 1986, BIOCHIM BIOPHYS ACTA, V883, P162, DOI 10.1016/0304-4165(86)90147-9
   SARNA T, 1992, J PHOTOCH PHOTOBIO B, V12, P215, DOI 10.1016/1011-1344(92)85027-R
   Schallreuter KU, 2008, EXP DERMATOL, V17, P395, DOI 10.1111/j.1600-0625.2007.00675.x
   SCHMITZ S, 1995, PHOTOCHEM PHOTOBIOL, V61, P650, DOI 10.1111/j.1751-1097.1995.tb09883.x
   Seagle BLL, 2005, J AM CHEM SOC, V127, P11220, DOI 10.1021/ja052773z
   SEALY RC, 1984, PHOTOCHEM PHOTOBIOL, V40, P453, DOI 10.1111/j.1751-1097.1984.tb04617.x
   Skurk T, 2007, J CLIN ENDOCR METAB, V92, P1023, DOI 10.1210/jc.2006-1055
   Song MJ, 2006, BIOCHEM BIOPH RES CO, V346, P739, DOI 10.1016/j.bbrc.2006.05.170
   STAR RA, 1995, P NATL ACAD SCI USA, V92, P8016, DOI 10.1073/pnas.92.17.8016
   Takeuchi S, 2004, P NATL ACAD SCI USA, V101, P15076, DOI 10.1073/pnas.0403994101
   THODY AJ, 1985, ACTA ENDOCRINOL-COP, V110, P313, DOI 10.1530/acta.0.1100313
   TOMITA Y, 1992, PIGM CELL RES, V5, P357, DOI 10.1111/j.1600-0749.1992.tb00562.x
   Trayhurn Paul, 2008, Archives of Physiology and Biochemistry, V114, P267, DOI [10.1080/13813450802306602, 10.1080/13813450802306602 ]
   Valverde P, 1996, Exp Dermatol, V5, P247, DOI 10.1111/j.1600-0625.1996.tb00125.x
   Vincent HK, 2006, INT J OBESITY, V30, P400, DOI 10.1038/sj.ijo.0803177
   Wang B, 2007, PFLUG ARCH EUR J PHY, V455, P479, DOI 10.1007/s00424-007-0301-8
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Wild SH, 2006, BMJ-BRIT MED J, V333, P1009, DOI 10.1136/bmj.39024.568738.43
   Wildman RP, 2009, CURR OPIN CLIN NUTR, V12, P438, DOI 10.1097/MCO.0b013e32832c6db7
   WOLBARSHT ML, 1981, APPL OPTICS, V20, P2184, DOI 10.1364/AO.20.002184
   Yoon SW, 2008, OSTEOARTHR CARTILAGE, V16, P115, DOI 10.1016/j.joca.2007.05.026
   Zou L, 2004, SHOCK, V22, P453, DOI 10.1097/01.shk.0000142255.15759.de
NR 100
TC 50
Z9 58
U1 1
U2 23
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1467-7881
J9 OBES REV
JI Obes. Rev.
PD MAY
PY 2011
VL 12
IS 501
BP e21
EP e31
DI 10.1111/j.1467-789X.2010.00773.x
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 752JN
UT WOS:000289687500005
PM 20576005
DA 2025-06-11
ER

PT J
AU Yang, M
   Xu, HY
   Yang, L
   Jiang, JJ
   Dong, BR
AF Yang, Ming
   Xu, Hanyue
   Yang, Ling
   Jiang, Jiaojiao
   Dong, Birong
TI Metabolic syndrome and disability in Chinese nonagenarians and
   centenarians
SO AGING CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Article
DE Activities of daily living; Disability; Metabolic syndrome
ID GENDER-DIFFERENCES; PREVALENCE; DECLINE; HEALTH; INTERLEUKIN-6;
   ASSOCIATION; DEPRESSION; DISEASE; IMPACT; LIFE
AB Background Little is known about the relationship between metabolic syndrome (MetS) and disability in the oldest old.
   Aims To investigate the possible association between MetS and disability among community-dwelling older adults aged >= 90 years.
   Methods This was a secondary analysis of a cross-sectional study. MetS was defined by the International Diabetes Federation Criteria. Activities of daily living (ADL) and instrumental activities of daily living (IADL) disabilities were evaluated using the physical self-maintenance scale and the Lawton-Brody IADL scale, respectively.
   Results We included 725 participants (mean age: 93.8 +/- 3.1 years). The prevalence of MetS was 13.0% in women and 9.8% in men, respectively. In women, ADL and IADL disabilities were more prevalent in the MetS group compared with the non-MetS group (ADL: 43.1 vs. 30.6%, p = 0.044; IADL: 73.8 vs. 59.8%, p = 0.030). After adjusting for relevant confounders, participants with MetS was associated with an increased risk of either ADL (odds ratio [OR] 1.81, 95% confidence interval [CI] 1.22-3.45) or IADL disability (OR 2.12, 95% CI 1.31-4.78) compared with those without MetS. In men, similar results were found with respect to the prevalence of ADL or IADL disability and the adjusted ORs, but the results were not statistically significant.
   Conclusion MetS is associated with an increased risk of either ADL or IADL disability in a study population of long-lived adults, especially in women.
C1 [Yang, Ming; Dong, Birong] Sichuan Univ, West China Hosp, Ctr Gerontol & Geriatr, 37 Guoxue Lane, Chengdu, Sichuan, Peoples R China.
   [Xu, Hanyue] Sichuan Univ, West China Sch Med, 37 Guoxue Lane, Chengdu, Sichuan, Peoples R China.
   [Yang, Ling] Sichuan Univ, West China Hosp, Outpatient Dept, 37 Guoxue Lane, Chengdu, Sichuan, Peoples R China.
   [Jiang, Jiaojiao] Sichuan Univ, West China Hosp, Ctr Rehabil, 37 Guoxue Lane, Chengdu, Sichuan, Peoples R China.
C3 Sichuan University; Sichuan University; Sichuan University; Sichuan
   University
RP Yang, M (corresponding author), Sichuan Univ, West China Hosp, Ctr Gerontol & Geriatr, 37 Guoxue Lane, Chengdu, Sichuan, Peoples R China.
EM yangmier@gmail.com
RI Yang, Ming/A-4973-2014
OI Yang, Ming/0000-0002-1875-1692
FU Construction Fund for Subjects of West China Hospital of Sichuan
   University [XK05001] Funding Source: Medline; the project of Science and
   Technology Bureau of Sichuan Province [2006Z09-006-4] Funding Source:
   Medline; the Sichuan Provincial Science and Technology Department
   [2016JY0058] Funding Source: Medline
CR Adams RJ, 2005, DIABETES CARE, V28, P2777, DOI 10.2337/diacare.28.11.2777
   Beigh SH, 2012, BIOINFORMATION, V8, P613, DOI 10.6026/97320630008613
   Blaum CS, 2007, J GERONTOL A-BIOL, V62, P766, DOI 10.1093/gerona/62.7.766
   Botoseneanu A, 2015, J AM GERIATR SOC, V63, P222, DOI 10.1111/jgs.13205
   Boudreau DM, 2009, METAB SYNDR RELAT D, V7, P305, DOI 10.1089/met.2008.0070
   Carriere I, 2014, J GERONTOL A-BIOL, V69, P79, DOI 10.1093/gerona/glt101
   Cesari M, 2015, J GERONTOL A-BIOL, V70, P457, DOI 10.1093/gerona/glu181
   Chan ACM, 1996, J AGING HEALTH, V8, P238, DOI 10.1177/089826439600800205
   Denys K, 2009, ACTA CLIN BELG, V64, P23, DOI 10.1179/acb.2009.006
   Ferrucci L, 2002, J AM GERIATR SOC, V50, P1947, DOI 10.1046/j.1532-5415.2002.50605.x
   Ghosh A, 2011, CARDIOVASC J AFR, V22, P295
   Grenon SM, 2014, J VASC SURG, V59, P1025, DOI 10.1016/j.jvs.2013.10.084
   Guarner V, 2015, INTERD T GERONT GERI, V40, P99, DOI 10.1159/000364934
   Ishii S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0112718
   KATZMAN R, 1988, J CLIN EPIDEMIOL, V41, P971, DOI 10.1016/0895-4356(88)90034-0
   Laudisio A, 2014, CLIN NUTR, V33, P626, DOI 10.1016/j.clnu.2013.08.005
   LAWTON MP, 1969, GERONTOLOGIST, V9, P179, DOI 10.1093/geront/9.3_Part_1.179
   Lee Jihye, 2016, J Prev Med Public Health, V49, P35, DOI 10.3961/jpmph.15.055
   Liaw FY, 2016, SCI REP-UK, V6, DOI 10.1038/srep22750
   Lu Yan-hui, 2006, Zhonghua Yi Xue Za Zhi, V86, P386
   Mabry RM, 2010, DIABETIC MED, V27, P593, DOI 10.1111/j.1464-5491.2010.02998.x
   Maher RL, 2014, EXPERT OPIN DRUG SAF, V13, P57, DOI 10.1517/14740338.2013.827660
   Makizako H, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2015-008462
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   Murtagh KN, 2004, AM J PUBLIC HEALTH, V94, P1406, DOI 10.2105/AJPH.94.8.1406
   Penninx BWJH, 2009, J GERONTOL A-BIOL, V64, P96, DOI 10.1093/gerona/gln005
   Peron EP, 2011, AM J GERIATR PHARMAC, V9, P378, DOI 10.1016/j.amjopharm.2011.10.002
   Roriz-Cruz M, 2007, J AM GERIATR SOC, V55, P374, DOI 10.1111/j.1532-5415.2007.01068.x
   Scuteri A, 2015, EUR J PREV CARDIOL, V22, P486, DOI 10.1177/2047487314525529
   Scuteri A, 2014, J ALZHEIMERS DIS, V42, pS401, DOI 10.3233/JAD-141416
   Scuteri A, 2011, ATHEROSCLEROSIS, V215, P459, DOI 10.1016/j.atherosclerosis.2010.12.023
   Taaffe DR, 2000, J GERONTOL A-BIOL, V55, pM709, DOI 10.1093/gerona/55.12.M709
   Yang M, 2014, J AM MED DIR ASSOC, V15, p[303, e1]
NR 34
TC 5
Z9 7
U1 0
U2 13
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1594-0667
EI 1720-8319
J9 AGING CLIN EXP RES
JI Aging Clin. Exp. Res.
PD AUG
PY 2018
VL 30
IS 8
BP 943
EP 949
DI 10.1007/s40520-017-0877-6
PG 7
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA GO1UR
UT WOS:000439744400007
PM 29235077
OA Green Published
DA 2025-06-11
ER

PT J
AU Gholami, A
   Doustmohammadian, A
   Shamshirgaran, SM
   Aminisani, N
   Azimi-Nezhad, M
   Abasi, H
   Hariri, M
AF Gholami, Ali
   Doustmohammadian, Azam
   Shamshirgaran, Seyed Morteza
   Aminisani, Nayyereh
   Azimi-Nezhad, Mohsen
   Abasi, Hamid
   Hariri, Mitra
TI Association Between Metabolic Syndrome and Health-Related Quality of
   Life in Older Adults: Findings from the IRanian Longitudinal Study on
   Ageing
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE metabolic syndrome; quality of life; aged
ID SELF-RATED HEALTH; SLEEP DURATION; DEPRESSION; DIAGNOSIS; OBESITY
AB Objectives: There are some studies without consensus on the association between metabolic syndrome (MetS) and health-related quality of life (HRQoL) and few studies among elderly participants; therefore, the aim of this study is evaluating the association between MetS and HRQoL between elderly participants after adjusting for possible confounding factors.Methods: A cross-sectional analysis was conducted with the data from baseline phase of the IRanian Longitudinal Study on Ageing. The MetS diagnosis was conducted based on the National Cholesterol Education Program Adult Treatment Panel III guidelines. The participants were 3452 subjects aged >= 60 years with and without MetS. The Prospective Epidemiological Research Studies in Iran version of the SF-12 questionnaire was used to examine subjects' perspectives on their well-being and general health level. The association between MetS and HRQoL was evaluated through multivariable linear regression model after adjusting for possible covariates.Results: MetS independently had an inverse association with subscales of HRQoL including physical functioning, physical problems, general health, social functioning, and emotional problems, even after fully adjusting for studied confounding factors. An inverse association was also observed between MetS and both mental component summary and physical component summary in the fully adjusted model.Conclusion: Older adults with MetS had a relatively worse physical and mental HRQoL in comparison with individuals without MetS. Independent of any underlying factors, the inverse association of MetS with HRQoL emphasizes the necessity of routine screening and treatment of MetS in older populations.
C1 [Gholami, Ali; Hariri, Mitra] Neyshabur Univ Med Sci, Noncommunicable Dis Res Ctr, Janbazan Ave, Neyshabur 1413993186, Iran.
   [Gholami, Ali] Neyshabur Univ Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Neyshabur, Iran.
   [Doustmohammadian, Azam] Iran Univ Med Sci, Firoozgar Hosp, Gastrointestinal & Liver Dis Res Ctr GILDRC, Tehran, Iran.
   [Shamshirgaran, Seyed Morteza; Aminisani, Nayyereh; Azimi-Nezhad, Mohsen] Neyshabur Univ Med Sci, Healthy Ageing Res Ctr, Neyshabur, Iran.
   [Abasi, Hamid] Neyshabur Univ Med Sci, Publ Hlth Dept, Neyshabur, Iran.
C3 Iran University of Medical Sciences
RP Hariri, M (corresponding author), Neyshabur Univ Med Sci, Noncommunicable Dis Res Ctr, Janbazan Ave, Neyshabur 1413993186, Iran.
EM hariri.mitra@yahoo.com
RI Doustmohammadian, Azam/HNQ-0687-2023; Shamshirgaran, Seyed/P-9524-2017;
   Gholami, Ali/I-1626-2018
FU Neyshabur University of Medical Sciences [3099]
FX The study was funded by Neyshabur University of Medical Sciences (grant
   number: 3099).
CR Akbaraly TN, 2009, DIABETES CARE, V32, P499, DOI 10.2337/dc08-1358
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Aminisani N, 2022, INT J EPIDEMIOL, V51, pe177, DOI 10.1093/ije/dyab272
   Anisimova AS, 2018, AGING-US, V10, P4269, DOI 10.18632/aging.101721
   [Anonymous], Statistical Methods and Data Analytics
   Arner P, 2022, J INTERN MED, V291, P611, DOI 10.1111/joim.13435
   Azimi-Nezhad M, 2022, J DIABETES METAB DIS, V21, P263, DOI 10.1007/s40200-022-00969-6
   Azizi F, 2010, ARCH IRAN MED, V13, P243
   Bilska K, 2023, NUTRIENTS, V15, DOI 10.3390/nu15214532
   Botoseneanu A, 2015, J AM GERIATR SOC, V63, P222, DOI 10.1111/jgs.13205
   Chang JH, 2015, INT J OCCUP MED ENV, V28, P1011, DOI 10.13075/ijomeh.1896.00359
   Corica F, 2008, INT J OBESITY, V32, P185, DOI 10.1038/sj.ijo.0803687
   Corica F, 2006, OBESITY, V14, P1429, DOI 10.1038/oby.2006.162
   Esteghamati A, 2009, DIABETIC MED, V26, P745, DOI 10.1111/j.1464-5491.2009.02756.x
   Fang PH, 2023, AGEING RES REV, V84, DOI 10.1016/j.arr.2022.101829
   Ford ES, 2008, ANN EPIDEMIOL, V18, P165, DOI 10.1016/j.annepidem.2007.10.009
   Frisman GH, 2009, EUR J CARDIOVASC NUR, V8, P207, DOI 10.1016/j.ejcnurse.2009.01.004
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Han JH, 2009, INT J CLIN PRACT, V63, P735, DOI 10.1111/j.1742-1241.2009.02021.x
   Hatami H, 2016, ARCH IRAN MED, V19, P577, DOI 0161908/AIM.0010
   Hatami O, 2021, BMC GERIATR, V21, DOI 10.1186/s12877-021-02337-0
   Hjellset VT, 2011, J IMMIGR MINOR HEALT, V13, P732, DOI 10.1007/s10903-010-9409-6
   Kalter-Leibovici O, 2010, ARCH INTERN MED, V170, P970, DOI 10.1001/archinternmed.2010.103
   Katano S, 2012, QUAL LIFE RES, V21, P1165, DOI 10.1007/s11136-011-0029-y
   Laudisio A, 2013, EUR J NUTR, V52, P307, DOI 10.1007/s00394-012-0337-1
   Limon VM, 2020, QUAL LIFE RES, V29, P2063, DOI 10.1007/s11136-020-02479-5
   Lin YH, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-99767-y
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Marcos-Delgado A, 2020, MED FAM-SEMERGEN, V46, P524, DOI 10.1016/j.semerg.2020.03.003
   Matsui K, 2020, SLEEP MED, V76, P80, DOI 10.1016/j.sleep.2020.10.012
   Montazeri A, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-341
   Noto S, 2023, HEALTHCARE-BASEL, V11, DOI 10.3390/healthcare11152131
   Okosun IS, 2013, DIABETES METAB SYND, V7, P154, DOI 10.1016/j.dsx.2013.06.007
   Orgaz P., 2015, J GEN PRACT, V03, P1
   Pakalska-Korcala A, 2008, KARDIOL POL, V66, P500
   Park SS, 2011, DIABETES RES CLIN PR, V91, P381, DOI 10.1016/j.diabres.2010.11.010
   Poustchi H, 2018, AM J EPIDEMIOL, V187, P647, DOI 10.1093/aje/kwx314
   Power M, 1998, SOC SCI MED, V46, P1569, DOI 10.1016/s0277-9536(98)00009-4
   Ramírez-Vélez Róbinson, 2008, Rev. salud pública, V10, P529
   Roriz-Cruz M, 2007, J AM GERIATR SOC, V55, P374, DOI 10.1111/j.1532-5415.2007.01068.x
   Rouch I, 2014, J NUTR HEALTH AGING, V18, P840, DOI [10.1007/s12603-014-0557-6, 10.1007/s12603-014-0488-2]
   Saboya PP, 2016, REV LAT-AM ENFERM, V24, DOI 10.1590/1518-8345.1573.2848
   Shin JA, 2013, J DIABETES INVEST, V4, P334, DOI 10.1111/jdi.12075
   Siboni FS, 2019, INT J PREVENTIVE MED, V10, DOI 10.4103/ijpvm.IJPVM_429_17
   Singh AK, 2013, CURR OPIN NEPHROL HY, V22, P198, DOI 10.1097/MNH.0b013e32835dda78
   WHO, 2004, LANCET, V363, P902, DOI 10.1016/S0140-6736(03)15268-3
   World Health Organization, Noncommunicable diseases-SEARO 2020
   World Health Organization, 2000, World Health Organ Tech Rep Ser, DOI DOI 10.1596/0-1952-1129-4
   Zhang KX, 2023, FRONT PUBLIC HEALTH, V11, DOI 10.3389/fpubh.2023.1253506
NR 49
TC 0
Z9 0
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD OCT 1
PY 2024
VL 22
IS 8
BP 575
EP 582
DI 10.1089/met.2023.0049
EA JUL 2024
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA I1R4I
UT WOS:001260937500001
PM 38959090
DA 2025-06-11
ER

PT J
AU Martinelli, I
   Tomassoni, D
   Moruzzi, M
   Roy, P
   Cifani, C
   Amenta, F
   Tayebati, SK
AF Martinelli, Ilenia
   Tomassoni, Daniele
   Moruzzi, Michele
   Roy, Proshanta
   Cifani, Carlo
   Amenta, Francesco
   Tayebati, Seyed Khosrow
TI Cardiovascular Changes Related to Metabolic Syndrome: Evidence in Obese
   Zucker Rats
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE heart; inflammation; obesity; oxidative stress; Zucker rats
ID EPICARDIAL ADIPOSE-TISSUE; NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN;
   OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; MYOCARDIAL-INFARCTION;
   LIPID-PEROXIDATION; ANIMAL-MODEL; INFLAMMATION; HEART
AB Metabolic syndrome (MetS) is a predictor of cardiovascular diseases, commonly associated with oxidative stress and inflammation. However, the pathogenic mechanisms are not yet fully elucidated. The aim of the study is to evaluate the oxidative status and inflammation in the heart of obese Zucker rats (OZRs) and lean Zucker rats (LZRs) at different ages. Morphological and morphometric analyses were performed in the heart. To study the oxidative status, the malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), protein oxidation, and antioxidant enzymes were measured in plasma and heart. To elucidate the inflammatory markers involved, immunohistochemistry and Western blot were performed for cellular adhesion molecules and proinflammatory cytokines. OZRs were characterized by hypertension, hyperlipidemia, hyperglycemia, and insulin resistance. The obesity increased MDA and decreased the activities of superoxide dismutase (SOD) in plasma as well as in the heart, associated with cardiomyocytes hypertrophy. OxyBlot in plasma and in heart showed an increase of oxidativestate proteins in OZRs. Vascular cell adhesion molecule-1, interleukin-6, and tumor necrosis factor-alpha expressions in OZRs were higher than those of LZRs. However, these processes did not induce apoptosis or necrosis of cardiomyocytes. Thus, MetS induces the lipid peroxidation and decreased antioxidant defense that leads to heart tissue changes and coronary inflammation.
C1 [Martinelli, Ilenia; Cifani, Carlo; Amenta, Francesco; Tayebati, Seyed Khosrow] Sch Pharm, Camerino 62032, Italy.
   [Martinelli, Ilenia; Cifani, Carlo; Amenta, Francesco; Tayebati, Seyed Khosrow] Univ Camerino, Camerino 62032, Italy.
   [Tomassoni, Daniele; Roy, Proshanta] Univ Camerino, Sch Biosci & Vet Med, Camerino 62032, Italy.
   [Moruzzi, Michele] Univ Leipzig, Dept Med, Leipzig 04103, Germany.
C3 University of Camerino; University of Camerino; Leipzig University
RP Tayebati, SK (corresponding author), Sch Pharm, Camerino 62032, Italy.; Tayebati, SK (corresponding author), Univ Camerino, Camerino 62032, Italy.
EM ilenia.martinelli@unicam.it; daniele.tomassoni@unicam.it;
   Michele.Moruzzi@medizin.uni-leipzig.de;
   proshanta.roy@studenti.unicam.it; carlo.cifani@unicam.it;
   francesco.amenta@unicam.it; khosrow.tayebati@unicam.it
RI Cifani, Carlo/AAC-5456-2022; Tayebati, Seyed/AGK-8739-2022
OI Roy, Proshanta/0000-0001-6482-6117; Tayebati, Seyed
   Khosrow/0000-0002-7219-6917; MARTINELLI, ILENIA/0000-0002-7702-7784;
   Cifani, Carlo/0000-0001-6180-828X
FU University of Camerino
FX This research was funded by the University of Camerino.
CR de Artiñano AA, 2009, BRIT J NUTR, V102, P1246, DOI 10.1017/S0007114509990729
   Alicka M, 2018, STEM CELLS INT, V2018, DOI 10.1155/2018/4274361
   Amenta F, 2003, HYPERTENSION, V41, P1330, DOI 10.1161/01.HYP.0000070116.11304.23
   Armutcu F, 2008, CLIN CHEM LAB MED, V46, P785, DOI 10.1515/CCLM.2008.166
   Bajaj NS, 2018, J AM COLL CARDIOL, V72, P707, DOI 10.1016/j.jacc.2018.05.049
   Banday AA, 2005, DIABETES, V54, P2219, DOI 10.2337/diabetes.54.7.2219
   Bender SB, 2015, HYPERTENSION, V65, P1082, DOI 10.1161/HYPERTENSIONAHA.114.04912
   Blankenberg S, 2003, NEW ENGL J MED, V349, P1605, DOI 10.1056/NEJMoa030535
   Bondia-Pons I, 2012, J PHYSIOL BIOCHEM, V68, P701, DOI 10.1007/s13105-012-0154-2
   Chandel NS, 2001, J BIOL CHEM, V276, P42728, DOI 10.1074/jbc.M103074200
   De Marchi E, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/564961
   Deshpande M, 2016, CELL BIOCHEM FUNCT, V34, P334, DOI 10.1002/cbf.3195
   Després JP, 2008, ARTERIOSCL THROM VAS, V28, P1039, DOI 10.1161/ATVBAHA.107.159228
   DHALLA AK, 1994, AM J PHYSIOL, V266, pH1280, DOI 10.1152/ajpheart.1994.266.4.H1280
   Ebenezer PJ, 2009, OBESITY, V17, P1994, DOI 10.1038/oby.2009.137
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Engin A, 2017, ADV EXP MED BIOL, V960, P1, DOI 10.1007/978-3-319-48382-5_1
   Esposito K, 2004, NUTR METAB CARDIOVAS, V14, P228, DOI 10.1016/S0939-4753(04)80048-6
   Ferenczyova K, 2020, MOLECULES, V25, DOI 10.3390/molecules25010187
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Fortuño A, 2006, DIABETES, V55, P209, DOI 10.2337/diabetes.55.1.209
   Francisqueti FV, 2017, REV ASSOC MED BRAS, V63, P85
   Freeman LM, 1999, J AM VET MED ASSOC, V215, P644
   Giugliano D, 2006, J AM COLL CARDIOL, V48, P677, DOI 10.1016/j.jacc.2006.03.052
   Grandl G, 2018, SEMIN IMMUNOPATHOL, V40, P215, DOI 10.1007/s00281-017-0666-5
   Hajjar DP, 2013, AM J PATHOL, V182, P1474, DOI 10.1016/j.ajpath.2013.01.010
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Hensley K, 2000, FREE RADICAL BIO MED, V28, P1456, DOI 10.1016/S0891-5849(00)00252-5
   Hill MF, 1996, AM J PATHOL, V148, P291
   JANERO DR, 1990, FREE RADICAL BIO MED, V9, P515, DOI 10.1016/0891-5849(90)90131-2
   Karam BS, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-017-0604-9
   Lacobellis G, 2008, HORM METAB RES, V40, P442, DOI 10.1055/s-2008-1062724
   Lavrovsky Y, 2000, EXP GERONTOL, V35, P521, DOI 10.1016/S0531-5565(00)00118-2
   Li RK, 1998, FREE RADICAL BIO MED, V24, P252, DOI 10.1016/S0891-5849(97)00224-4
   Libby P, 2002, CIRCULATION, V105, P1135, DOI 10.1161/hc0902.104353
   Vieira RAL, 2014, NUTR HOSP, V30, P223, DOI [10.3305/nh.2014.30.2.7416, 10.3305/nh.2014.30.2.741]
   Maedler K, 2011, HANDB EXP PHARMACOL, V203, P257, DOI 10.1007/978-3-642-17214-4_11
   Malnick SDH, 2006, QJM-INT J MED, V99, P565, DOI 10.1093/qjmed/hcl085
   Marseglia L, 2015, INT J MOL SCI, V16, P378, DOI 10.3390/ijms16010378
   Martinelli I., 2003, ACCUMULATION EXTRACE
   Martinelli I, 2017, CNS NEUROL DISORD-DR, V16, P664, DOI 10.2174/1871527316666170428123853
   Maulik SK, 2012, TOXICOL MECH METHOD, V22, P359, DOI 10.3109/15376516.2012.666650
   Mittwede PN, 2016, SHOCK, V45, P349, DOI 10.1097/SHK.0000000000000512
   Murase T, 2012, HYPERTENS RES, V35, P186, DOI 10.1038/hr.2011.157
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Otani H, 2011, ANTIOXID REDOX SIGN, V15, P1911, DOI 10.1089/ars.2010.3739
   Packer M, 2018, J AM COLL CARDIOL, V71, P2360, DOI 10.1016/j.jacc.2018.03.509
   Palmieri VO, 2006, J NUTR, V136, P3022, DOI 10.1093/jn/136.12.3022
   Picchi A, 2006, CIRC RES, V99, P69, DOI 10.1161/01.RES.0000229685.37402.80
   Poirier P, 2006, CIRCULATION, V113, P898, DOI 10.1161/CIRCULATIONAHA.106.171016
   Porres JM, 2020, EUR J NUTR, V59, P3473, DOI 10.1007/s00394-020-02181-9
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   Ridker PM, 2000, CIRCULATION, V101, P2149, DOI 10.1161/01.CIR.101.18.2149
   Ridker PM, 2004, CIRCULATION, V109, P2818, DOI 10.1161/01.CIR.0000132467.45278.59
   Ridker PM, 2000, CIRCULATION, V101, P1767, DOI 10.1161/01.CIR.101.15.1767
   Riojas-Hernández A, 2015, LIFE SCI, V141, P32, DOI 10.1016/j.lfs.2015.09.018
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Russo I, 2008, ENDOCRINOLOGY, V149, P1480, DOI 10.1210/en.2007-0920
   Santilli F, 2015, CURR MED CHEM, V22, P582, DOI 10.2174/0929867322666141128163739
   Sikaris Ken A, 2004, Clin Biochem Rev, V25, P165
   Steven S, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/7092151
   Taddei S, 2003, CURR PHARM DESIGN, V9, P2385, DOI 10.2174/1381612033453866
   Tayebati SK, 2016, CLIN EXP HYPERTENS, V38, P30, DOI 10.3109/10641963.2015.1047950
   Tomassoni D, 2013, NEUROSCI LETT, V543, P136, DOI 10.1016/j.neulet.2013.03.025
   Tsikas D, 2017, ANAL BIOCHEM, V524, P13, DOI 10.1016/j.ab.2016.10.021
   Tune JD, 2017, TRANSL RES, V183, P57, DOI 10.1016/j.trsl.2017.01.001
   Uosaki H, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023657
   Vazzana N, 2011, CURR MED CHEM, V18, P5267, DOI 10.2174/092986711798184299
   Wang TT, 2018, CYTOKINE GROWTH F R, V44, P38, DOI 10.1016/j.cytogfr.2018.10.002
   Wang ZX, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/535918
   Woodiwiss AJ, 2015, CURR HYPERTENS REP, V17, DOI 10.1007/s11906-015-0539-z
   Zanni MV, 2010, CLIN ENDOCRINOL, V73, P48, DOI 10.1111/j.1365-2265.2009.03741.x
NR 72
TC 27
Z9 27
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2020
VL 21
IS 6
AR 2035
DI 10.3390/ijms21062035
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA LJ0UU
UT WOS:000529890200131
PM 32188150
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Joshi, P
   Joshi, S
   Semwal, DK
   Verma, K
   Dwivedi, J
   Sharma, S
AF Joshi, Priyanka
   Joshi, Sushil
   Semwal, Deepak Kumar
   Verma, Kanika
   Dwivedi, Jaya
   Sharma, Swapnil
TI Role of curcumin in ameliorating hypertension and associated conditions:
   a mechanistic insight
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Curcumin; Turmeric; Anti-hypertensive activity; Oxidative stress; Nitric
   oxide
ID NF-KAPPA-B; NITRIC-OXIDE SYNTHASE; TUMOR-NECROSIS-FACTOR; PULMONARY
   ARTERIAL-HYPERTENSION; MICROVASCULAR ENDOTHELIAL-CELLS;
   ANGIOTENSIN-CONVERTING ENZYME; INDUCED INFLAMMATORY RESPONSE; INDUCED
   VASCULAR DYSFUNCTION; ISCHEMIA-REPERFUSION INJURY; OXIDATIVE STRESS
AB Curcumin, belongs to the curcuminoid family, is a natural phenolic compound, presenting low bioavailability and pleiotropic activity. Since ancient times, curcumin has been in use as food spices and folk remedy to treat cough, cold, cuts and wounds, and skin diseases. Preclinical and clinical studies have indicated that curcumin acts a promising therapeutic agent in the management of a wide array of health issues, viz., hyperlipidemia, metabolic syndrome, anxiety, arthritis, cancer and inflammatory diseases. Owing to its enormous potential, recent research has been focused on the synthesis of curcumin and its analogues for the management of metabolic disorders. In the current scenario, hypertension is considered as a key risk factor due to its involvement in various pathogeneses. Mechanistically, curcumin and its analogues like hexahydrocurcumin, tetrahydrocurcumin, etc. have been reported to elicit anti-hypertensive effect through diverse signalling pathways, viz., pathway mediated by Nrf2-ARE, NF-kB, NO/cGMP/PDE5/MMPs, RAAS/ACE, HAT/HDAC, G0/G1/apoptosis, CYP3A4, UCP2/PARP, VEGF/STAT/AXL/tyrosine kinase and TGF-beta/Smad-mediated pathways. Thus, the present review has been aimed to highlight different molecular pathways involved in the amelioration of hypertension and associated conditions.
C1 [Joshi, Priyanka; Verma, Kanika; Sharma, Swapnil] Banasthali Vidyapith, Dept Pharm, Banasthali 304022, Rajasthan, India.
   [Joshi, Priyanka; Joshi, Sushil] Patanjali Ayurved Ltd, R&D, Patanjali Food & Herbal Pk, Haridwar, Uttarakhand, India.
   [Semwal, Deepak Kumar] Uttarakhand Ayurved Univ, Fac Biomed Sci, Dept Phytochem, Dehra Dun, Uttarakhand, India.
   [Dwivedi, Jaya] Banasthali Vidyapith, Dept Chem, Banasthali, Rajasthan, India.
C3 Banasthali Vidyapith; Banasthali Vidyapith
RP Sharma, S (corresponding author), Banasthali Vidyapith, Dept Pharm, Banasthali 304022, Rajasthan, India.
EM skspharmacology@gmail.com
RI Sharma, Swapnil/AAV-4850-2020; Verma, Kanika/GZA-3489-2022; Semwal,
   Deepak/K-4380-2016
OI Semwal, Deepak/0000-0003-3105-0759; Sharma, Swapnil/0000-0003-2639-7096
CR Abarikwu SO, 2012, J BIOCHEM MOL TOXIC, V26, P477, DOI 10.1002/jbt.21449
   Abe Y, 1999, PHARMACOL RES, V39, P41, DOI 10.1006/phrs.1998.0404
   ADAMS ML, 1992, LIFE SCI, V50, pPL35, DOI 10.1016/0024-3205(92)90384-2
   Aggarwal BB, 2007, BIOCHEM PHARMACOL, V73, P1024, DOI 10.1016/j.bcp.2006.12.010
   Aggarwal BB, 2009, TRENDS PHARMACOL SCI, V30, P85, DOI 10.1016/j.tips.2008.11.002
   Akinyemi AJ, 2016, PLANTA MED, V82, P612, DOI 10.1055/s-0042-102062
   Akinyemi AJ, 2015, J FUNCT FOODS, V17, P792, DOI 10.1016/j.jff.2015.06.011
   Alajbegovic Salem, 2013, Med Arch, V67, P174
   Alamgir ANM, 2017, PROG DRUG RES, V73, P1, DOI 10.1007/978-3-319-63862-1
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   ALVAREZ JG, 1987, J ANDROL, V8, P338
   Anderson JL, 2017, NEW ENGL J MED, V376, P2053, DOI 10.1056/NEJMra1606915
   ANDERSON S, 1986, J HYPERTENS, V4, pS242
   Anderson WP, 2000, HYPERTENSION, V36, P648, DOI 10.1161/01.HYP.36.4.648
   Anrather J, 2006, J BIOL CHEM, V281, P5657, DOI 10.1074/jbc.M506172200
   Ara C, 2006, CELL BIOCHEM FUNCT, V24, P443, DOI 10.1002/cbf.1245
   Asari Y, 2018, CLIN RHEUMATOL, V37, P3373, DOI 10.1007/s10067-018-4142-y
   Azu OO, 2015, ANDROLOGIA, V47, P123, DOI 10.1111/and.12233
   BAEUERLE PA, 1994, ANNU REV IMMUNOL, V12, P141, DOI 10.1146/annurev.iy.12.040194.001041
   Bagchi D, 1997, FREE RADICAL BIO MED, V22, P471, DOI 10.1016/S0891-5849(96)00352-8
   Balasuriya BWN., 2011, HLTH DIS, V5, P172
   Balkau B, 1999, DIABETIC MED, V16, P442
   Baqi N, 1996, J AM SOC NEPHROL, V7, P924
   BARNETT AH, 1994, BRIT MED BULL, V50, P397, DOI 10.1093/oxfordjournals.bmb.a072899
   Barst RJ, 2004, J AM COLL CARDIOL, V43, p40S, DOI 10.1016/j.jacc.2004.02.032
   BECKMAN JS, 1990, P NATL ACAD SCI USA, V87, P1620, DOI 10.1073/pnas.87.4.1620
   Beckman JS, 1996, AM J PHYSIOL-CELL PH, V271, pC1424
   Bengmark S, 2006, JPEN-PARENTER ENTER, V30, P45, DOI 10.1177/014860710603000145
   Berridge MJ, 2003, NAT REV MOL CELL BIO, V4, P517, DOI 10.1038/nrm1155
   Bharti AC, 2003, J IMMUNOL, V171, P3863, DOI 10.4049/jimmunol.171.7.3863
   Bhullar KS, 2013, MOLECULES, V18, P5389, DOI 10.3390/molecules18055389
   Binion DG, 2008, GUT, V57, P1509, DOI 10.1136/gut.2008.152496
   Boonla O, 2014, NITRIC OXIDE-BIOL CH, V42, P44, DOI 10.1016/j.niox.2014.09.001
   Bouvet C, 2005, HYPERTENSION, V45, P432, DOI 10.1161/01.HYP.0000154680.44184.01
   Braga VA, 2011, BRAZ J MED BIOL RES, V44, P871, DOI 10.1590/S0100-879X2011007500088
   BREDT DS, 1994, ANNU REV BIOCHEM, V63, P175, DOI 10.1146/annurev.bi.63.070194.001135
   Briones AM, 2009, HYPERTENSION, V54, P142, DOI 10.1161/HYPERTENSIONAHA.109.133710
   Bronte E, 2013, MED HYPOTHESES, V81, P923, DOI 10.1016/j.mehy.2013.08.016
   Cai WY, 2008, NEUROPHARMACOLOGY, V55, P127, DOI 10.1016/j.neuropharm.2008.04.023
   Camacho-Barquero L, 2007, INT IMMUNOPHARMACOL, V7, P333, DOI 10.1016/j.intimp.2006.11.006
   Carranza A, 2011, LIFE SCI, V88, P307, DOI 10.1016/j.lfs.2010.12.005
   Castro MA, 2008, ATHEROSCLEROSIS, V198, P320, DOI 10.1016/j.atherosclerosis.2007.10.011
   Chakravarti N, 2010, CANCER PREV RES, V3, P331, DOI 10.1158/1940-6207.CAPR-09-0076
   CHAN MMY, 1995, BIOCHEM PHARMACOL, V49, P1551, DOI 10.1016/0006-2952(95)00171-U
   Chatziantoniou C., 1998, ROLE ENDOTHELIN J CL, V101, P2780, DOI DOI 10.1172/JCI2132
   Chen HW, 1998, BRIT J PHARMACOL, V124, P1029, DOI 10.1038/sj.bjp.0701914
   Chiu J, 2009, NUTRITION, V25, P964, DOI 10.1016/j.nut.2008.12.007
   Chrysant SG, 2013, CURR HYPERTENS REP, V15, P475, DOI 10.1007/s11906-013-0377-9
   Chwalisz K, 1998, HUM REPROD, V13, P245, DOI 10.1093/humrep/13.2.245
   Cione E, 2020, MOLECULES, V25, DOI 10.3390/molecules25010063
   Coban D, 2012, MOL NUTR FOOD RES, V56, P1270, DOI 10.1002/mnfr.201100818
   Cohly HHP, 1998, FREE RADICAL BIO MED, V24, P49, DOI 10.1016/S0891-5849(97)00140-8
   COOKE JP, 1991, J CLIN INVEST, V88, P1663, DOI 10.1172/JCI115481
   Cruz C, 2007, AM J PHYSIOL-RENAL, V293, pF1691, DOI 10.1152/ajprenal.00235.2007
   Cuadrado A, 2009, EXPERT OPIN THER TAR, V13, P319, DOI [10.1517/13543780802716501, 10.1517/13543780802716501 ]
   Cuypers A, 2010, BIOMETALS, V23, P927, DOI 10.1007/s10534-010-9329-x
   Day SM, 2003, CIRCULATION, V107, P2601, DOI 10.1161/01.CIR.0000066910.02844.D0
   Debelle L, 1999, INT J BIOCHEM CELL B, V31, P261, DOI 10.1016/S1357-2725(98)00098-3
   Devadasu VR, 2012, EUR J PHARM BIOPHARM, V80, P578, DOI 10.1016/j.ejpb.2011.12.008
   Dinkova-Kostova AT, 2008, MOL NUTR FOOD RES, V52, pS128, DOI 10.1002/mnfr.200700195
   DOLLERY CM, 1995, CIRC RES, V77, P863, DOI 10.1161/01.RES.77.5.863
   DONADIO JV, 1995, LUPUS, V4, P109, DOI 10.1177/096120339500400206
   Dorta DJ, 2003, J INORG BIOCHEM, V97, P251, DOI 10.1016/S0162-0134(03)00314-3
   Duron E, 2008, VASC HEALTH RISK MAN, V4, P363
   Düsing R, 2003, BLOOD PRESSURE, V12, P29, DOI 10.1080/08038020310021967
   Einhorn Daniel, 2003, Endocr Pract, V9, P237
   Ejaz A, 2009, J NUTR, V139, P919, DOI 10.3945/jn.108.100966
   El-Bassossy HM, 2011, N-S ARCH PHARMACOL, V384, P277, DOI 10.1007/s00210-011-0669-z
   El-Bassossy HM, 2009, BRIT J PHARMACOL, V158, P1527, DOI 10.1111/j.1476-5381.2009.00419.x
   Emre S, 2001, NEPHRON, V87, P118, DOI 10.1159/000045899
   Endemann DH, 2004, J AM SOC NEPHROL, V15, P1983, DOI 10.1097/01.ASN.0000132474.50966.DA
   Epstein J, 2010, BRIT J NUTR, V103, P1545, DOI 10.1017/S0007114509993667
   Eum KD, 2008, SCI TOTAL ENVIRON, V407, P147, DOI 10.1016/j.scitotenv.2008.08.037
   Eybl V, 2006, TOXICOLOGY, V225, P150, DOI 10.1016/j.tox.2006.05.011
   Fan J, 2012, NUTRITION, V28, P1068, DOI 10.1016/j.nut.2012.02.006
   Fazal Y, 2015, J RENIN-ANGIO-ALDO S, V16, P1046, DOI 10.1177/1470320314545777
   Felmeden DC, 2005, EXPERT OPIN INV DRUG, V14, P1319, DOI 10.1517/13543784.14.11.1319
   Fernandez M, 2004, GASTROENTEROLOGY, V126, P886, DOI 10.1053/j.gastro.2003.12.012
   Fiorillo C, 2008, FREE RADICAL BIO MED, V45, P839, DOI 10.1016/j.freeradbiomed.2008.06.013
   Flammer AJ, 2012, CIRCULATION, V126, P753, DOI 10.1161/CIRCULATIONAHA.112.093245
   Fleenor BS, 2013, EXP GERONTOL, V48, P269, DOI 10.1016/j.exger.2012.10.008
   Fresquet F, 2006, BRIT J PHARMACOL, V148, P714, DOI 10.1038/sj.bjp.0706779
   Fukui T, 1997, CIRC RES, V80, P45, DOI 10.1161/01.RES.80.1.45
   Fuller B, 2003, CRYOBIOLOGY, V46, P284, DOI 10.1016/S0011-2240(03)00027-0
   Galiè N, 2004, EUR HEART J, V25, P2243, DOI 10.1016/j.ehj.2004.09.014
   Gauss KA, 2007, J LEUKOCYTE BIOL, V82, P729, DOI 10.1189/jlb.1206735
   Ghayur MN, 2005, VASC PHARMACOL, V43, P234, DOI 10.1016/j.vph.2005.07.003
   Gosline J, 2002, PHILOS T R SOC B, V357, P121, DOI 10.1098/rstb.2001.1022
   GRIFFITHS MJD, 1993, BRIT J PHARMACOL, V110, P963, DOI 10.1111/j.1476-5381.1993.tb13907.x
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Guimaraes DD, 2012, CLIN EXP PHARMACOL P, V39, P373, DOI 10.1111/j.1440-1681.2012.05679.x
   Guo Y., 2010, FARMACIA, V68, P2
   Gupta B, 1999, INT J IMMUNOPHARMACO, V21, P745, DOI 10.1016/S0192-0561(99)00050-8
   Guyton AC., 1996, TXB MED PHYSL
   Haefliger JA, 1999, ARTERIOSCL THROM VAS, V19, P1615, DOI 10.1161/01.ATV.19.7.1615
   Han Y, 2019, J NUTR BIOCHEM, V72, DOI 10.1016/j.jnutbio.2019.07.003
   Heiss EH, 2009, J BIOL CHEM, V284, P31579, DOI 10.1074/jbc.M109.009175
   Higashi Y, 2014, TRENDS CARDIOVAS MED, V24, P165, DOI 10.1016/j.tcm.2013.12.001
   Hijriani Nursela, 2020, J Basic Clin Physiol Pharmacol, V30, DOI 10.1515/jbcpp-2019-0280
   Hirose F, 2004, HYPERTENSION, V43, P1098, DOI 10.1161/01.HYP.0000123069.02156.8a
   Hlavacková L, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-72
   Hsu SJ, 2017, BIOSCIENCE REP, V37, DOI [10.1042/BSR20171015, 10.1042/bsr20171015]
   HUANG HC, 1992, EUR J PHARMACOL, V221, P381
   Huang HC, 2000, SCAND J GASTROENTERO, V35, P1308
   Humphrey JD, 2008, HYPERTENSION, V52, P195, DOI 10.1161/HYPERTENSIONAHA.107.103440
   Iwakiri Y, 2014, J HEPATOL, V61, P912, DOI 10.1016/j.jhep.2014.05.047
   Jackson WF, 2000, HYPERTENSION, V35, P173, DOI 10.1161/01.HYP.35.1.173
   JEYENDRAN RS, 1984, J REPROD FERTIL, V70, P219
   Jiang L, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2016-014316
   Jiang N, 2020, PHARM BIOL, V58, P465, DOI 10.1080/13880209.2020.1764060
   Joe B, 1997, LIPIDS, V32, P1173, DOI 10.1007/s11745-997-0151-8
   Jordan JD, 2016, HYPERT STROKE, P151
   Joshi P, 2021, MINI-REV MED CHEM, V21, P2434, DOI 10.2174/1389557521666210122153823
   Joshi P, 2021, IND CROP PROD, V162, DOI 10.1016/j.indcrop.2021.113278
   Kam A, 2015, J PHARM PHARM SCI, V18, P424, DOI 10.18433/J3ZC8G
   Kamanna VS, 2012, AM J NEPHROL, V35, P114, DOI 10.1159/000334939
   Kansanen E, 2012, FREE RADICAL BIO MED, V52, P973, DOI 10.1016/j.freeradbiomed.2011.11.038
   Kapakos G, 2012, INDIAN J BIOCHEM BIO, V49, P306
   Karatepe O, 2009, TRANSPL P, V41, P3611, DOI 10.1016/j.transproceed.2009.08.002
   KEELEY FW, 1991, LAB INVEST, V64, P499
   Khajehdehi P, 2012, J RENAL NUTR, V22, P50, DOI 10.1053/j.jrn.2011.03.002
   Khalfi F, 1998, BIOL PHARM BULL, V21, P109
   Kim HJ, 2010, AM J PHYSIOL-RENAL, V298, pF662, DOI 10.1152/ajprenal.00421.2009
   KIM YC, 1995, J UROLOGY, V153, P807, DOI 10.1016/S0022-5347(01)67727-9
   Kitamoto S, 2000, CIRCULATION, V102, P806, DOI 10.1161/01.CIR.102.7.806
   Kruangtip O, 2015, J PHARM PHARMACOL, V67, P87, DOI 10.1111/jphp.12302
   Kshirsagar AV, 2000, AM J KIDNEY DIS, V35, P695, DOI 10.1016/S0272-6386(00)70018-7
   Kukongviriyapan U, 2016, TOHOKU J EXP MED, V239, P25, DOI 10.1620/tjem.239.25
   Kukongviriyapan U, 2014, NUTRIENTS, V6, P1194, DOI 10.3390/nu6031194
   Kusaka Y, 2000, AM J PHYSIOL-HEART C, V279, pH1087, DOI 10.1152/ajpheart.2000.279.3.H1087
   Lan C, 2018, BMC CARDIOVASC DISOR, V18, DOI 10.1186/s12872-018-0768-6
   Landmesser U, 2003, J CLIN INVEST, V111, P1201, DOI 10.1172/JCI200314172
   Landmesser U, 2007, ARTERIOSCL THROM VAS, V27, P943, DOI 10.1161/01.ATV.0000258415.32883.bf
   Lee BK, 2012, AM J IND MED, V55, P1060, DOI 10.1002/ajim.22078
   Lee KU, 2005, CIRC RES, V96, P1200, DOI 10.1161/01.RES.0000170075.73039.5b
   Lee MS, 2011, ENVIRON RES, V111, P171, DOI 10.1016/j.envres.2010.10.006
   Lee MY, 2008, ANTIOXID REDOX SIGN, V10, P1045, DOI 10.1089/ars.2007.1986
   Lei J, 2013, NITRIC OXIDE-BIOL CH, V35, P175, DOI 10.1016/j.niox.2013.09.004
   Lekshmi PC, 2014, J FOOD SCI TECH MYS, V51, P3910, DOI 10.1007/s13197-013-0953-7
   Lemarié CA, 2010, J MOL CELL CARDIOL, V48, P433, DOI 10.1016/j.yjmcc.2009.09.018
   Leong XinFang Leong XinFang, 2018, Biomedical & Pharmacology Journal, V11, P1829
   Li Jun-Li, 2014, Zhongguo Ying Yong Sheng Li Xue Za Zhi, V30, P451
   Li MY, 2014, MOL MED REP, V10, P3261, DOI 10.3892/mmr.2014.2615
   Li WH, 2003, NATURE, V426, P450, DOI 10.1038/nature02145
   Ling Y, 2012, AM J RESP CRIT CARE, V186, P790, DOI 10.1164/rccm.201203-0383OC
   Liu F, 2000, FREE RADICAL BIO MED, V28, P55, DOI 10.1016/S0891-5849(99)00196-3
   LIU J, 1991, CELL, V66, P807, DOI 10.1016/0092-8674(91)90124-H
   Liu XJ, 2009, J BIOL CHEM, V284, P15564, DOI 10.1074/jbc.M806584200
   Liu YZ, 2008, J CARDIOVASC PHARM, V52, P422, DOI 10.1097/FJC.0b013e31818aed93
   López-Ongil S, 1998, BRIT J PHARMACOL, V124, P447, DOI 10.1038/sj.bjp.0701847
   Mahmoud MF, 2012, ARCH PHARM RES, V35, P155, DOI 10.1007/s12272-012-0117-8
   Mahmoud MF, 2014, PHARM BIOL, V52, P972, DOI 10.3109/13880209.2013.874465
   Majithiya JB, 2005, J CARDIOVASC PHARM, V46, P697, DOI 10.1097/01.fjc.0000183720.85014.24
   Majithiya JB, 2005, J TRACE ELEM MED BIO, V18, P211, DOI 10.1016/j.jtemb.2004.12.001
   Mallick C, 2007, BIOL PHARM BULL, V30, P84, DOI 10.1248/bpb.30.84
   Manjunatha H, 2007, CAN J PHYSIOL PHARM, V85, P588, DOI 10.1139/Y07-044
   Marini R, 1999, REV RHUM, V66, P303
   Martinez MLL, 2008, EUR J PHARMACOL, V591, P224, DOI 10.1016/j.ejphar.2008.06.096
   Mattiasson G, 2006, ANTIOXID REDOX SIGN, V8, P1, DOI 10.1089/ars.2006.8.1
   MCCALL TB, 1989, BIOCHEM J, V261, P293, DOI 10.1042/bj2610293
   McLaughlin VV, 2011, CURR PROB CARDIOLOGY, V36, P461, DOI 10.1016/j.cpcardiol.2011.08.002
   Mehta PK, 2007, AM J PHYSIOL-CELL PH, V292, pC82, DOI 10.1152/ajpcell.00287.2006
   Meng Z, 2014, ACTA PHARMACOL SIN, V35, P1247, DOI 10.1038/aps.2014.63
   Metzler M., 2013, CURCUMIN UPTAKE META, V39, P14
   Mochida H, 2002, EUR J PHARMACOL, V440, P45, DOI 10.1016/S0014-2999(02)01339-0
   Molina-Jijón E, 2011, FREE RADICAL BIO MED, V51, P1543, DOI 10.1016/j.freeradbiomed.2011.07.018
   MONCADA S, 1991, EUR J CLIN INVEST, V21, P361, DOI 10.1111/j.1365-2362.1991.tb01383.x
   Moohammadaree A, 2015, PHYTOTHER RES, V29, P1806, DOI 10.1002/ptr.5448
   Motterlini R, 2000, FREE RADICAL BIO MED, V28, P1303, DOI 10.1016/S0891-5849(00)00294-X
   Murugan P, 2007, BASIC CLIN PHARMACOL, V101, P241, DOI 10.1111/j.1742-7843.2007.00109.x
   Murugan P, 2006, LIFE SCI, V79, P1720, DOI 10.1016/j.lfs.2006.06.001
   Nair AR, 2013, INT J MOL SCI, V14, P6116, DOI 10.3390/ijms14036116
   Nakmareong S, 2012, HYPERTENS RES, V35, P418, DOI 10.1038/hr.2011.180
   Nakmareong S, 2011, N-S ARCH PHARMACOL, V383, P519, DOI 10.1007/s00210-011-0624-z
   Newby AC, 2006, CARDIOVASC RES, V69, P614, DOI 10.1016/j.cardiores.2005.08.002
   Nwokocha CR, 2013, CARDIOVASC TOXICOL, V13, P357, DOI 10.1007/s12012-013-9216-0
   Ogah OS, 2012, WORLD J CARDIOL, V4, P327, DOI 10.4330/wjc.v4.i12.327
   Okuno S, 2004, J NEUROSCI, V24, P7879, DOI 10.1523/JNEUROSCI.1745-04.2004
   Olsén L, 2012, INT J HYG ENVIR HEAL, V215, P411, DOI 10.1016/j.ijheh.2011.11.004
   ONER G, 1995, BIOL TRACE ELEM RES, V48, P111, DOI 10.1007/BF02789083
   Oudot A, 2010, J SEX MED, V7, P79, DOI 10.1111/j.1743-6109.2009.01551.x
   Pan MH, 2000, BIOCHEM PHARMACOL, V60, P1665, DOI 10.1016/S0006-2952(00)00489-5
   Pan Y, 2013, J NUTR BIOCHEM, V24, P146, DOI 10.1016/j.jnutbio.2012.03.012
   Pan Y, 2012, BRIT J PHARMACOL, V166, P1169, DOI 10.1111/j.1476-5381.2012.01854.x
   Panahi Y, 2017, DRUG RES, V67, P244, DOI 10.1055/s-0043-100019
   Panighini A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0064863
   Pantazis P, 2010, ALTERN THER HEALTH M, V16, P12
   Paravicini TM, 2008, DIABETES CARE, V31, pS170, DOI 10.2337/dc08-s247
   Pari L, 2005, J PHARM PHARM SCI, V8, P115
   Pari L, 2007, J MED FOOD, V10, P323, DOI 10.1089/jmf.2006.058
   Park CB, 2015, BIOORGAN MED CHEM, V23, P6673, DOI 10.1016/j.bmc.2015.09.004
   Patel J, 2009, INDIAN J BIOCHEM BIO, V46, P66
   Patel P., 2017, INSIGHTS BLOOD PRESS, V3, P327, DOI [10.21767/2471-9897.1000015, DOI 10.21767/2471-9897.1000015]
   Perez-Torres Israel, 2013, Cardiovascular & Hematological Agents in Medicinal Chemistry, V11, P25
   Preez R.D., 2019, Nutrients, V11, P1542, DOI [10.3390/nu11071542, DOI 10.3390/NU11071542]
   Price LC, 2012, CHEST, V141, P210, DOI 10.1378/chest.11-0793
   Priyadarsini KI, 2009, J PHOTOCH PHOTOBIO C, V10, P81, DOI 10.1016/j.jphotochemrev.2009.05.001
   Prozialeck WC, 2006, LIFE SCI, V79, P1493, DOI 10.1016/j.lfs.2006.05.007
   PROZIALECK WC, 1991, BIOCHEM BIOPH RES CO, V181, P1118, DOI 10.1016/0006-291X(91)92054-N
   Prozialeck WC, 2000, TOXICOL APPL PHARM, V164, P231, DOI 10.1006/taap.2000.8905
   Rabinovitch M, 2008, J CLIN INVEST, V118, P2372, DOI 10.1172/JCI33452
   Rachmawati H, 2016, SCI PHARM, V84, P131, DOI 10.3797/scipharm.ISP.2015.05
   Rahman I, 2006, BIOCHEM PHARMACOL, V72, P1439, DOI 10.1016/j.bcp.2006.07.004
   Raitakari OT, 2000, BRIT J CLIN PHARMACO, V50, P397, DOI 10.1046/j.1365-2125.2000.00277.x
   Ramaswami G, 2004, J VASC SURG, V40, P1216, DOI 10.1016/j.jvs.2004.09.021
   García-Niño WR, 2014, FOOD CHEM TOXICOL, V69, P182, DOI 10.1016/j.fct.2014.04.016
   Rebolledo A, 2010, CARDIOVASC DIABETOL, V9, DOI 10.1186/1475-2840-9-65
   Rm C., 1992, J CLINI INVEST, V90, P1116, DOI [10.1172/JCI115929, DOI 10.1172/JCI115929]
   RUBY AJ, 1995, CANCER LETT, V94, P79, DOI 10.1016/0304-3835(95)03827-J
   Rungseesantivanon S, 2010, BMC COMPLEM ALTERN M, V10, DOI 10.1186/1472-6882-10-57
   Sagiroglu T, 2014, TOXICOL IND HEALTH, V30, P316, DOI 10.1177/0748233712456065
   Sánchez M, 2006, J HYPERTENS, V24, P75, DOI 10.1097/01.hjh.0000198029.22472.d9
   Sánchez-Lozada LG, 2005, KIDNEY INT, V67, P237, DOI 10.1111/j.1523-1755.2005.00074.x
   Sandur SK, 2007, CARCINOGENESIS, V28, P1765, DOI 10.1093/carcin/bgm123
   Sangartit W., 2013, SRINAGARIND MED J, V28, P271
   Sangartit W, 2016, VASC PHARMACOL, V87, P199, DOI 10.1016/j.vph.2016.10.001
   Santillo M, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00194
   Santos-Parker JR, 2017, AGING-US, V9, P187, DOI 10.18632/aging.101149
   Sarr M, 2006, CARDIOVASC RES, V71, P794, DOI 10.1016/j.cardiores.2006.05.022
   Sassi ML., 2001, CARBOXYTERMINAL DEGR, P305
   Satarug S, 2005, TOXICOL LETT, V157, P57, DOI 10.1016/j.toxlet.2005.01.004
   SATTA J, 1995, J VASC SURG, V22, P155, DOI 10.1016/S0741-5214(95)70110-9
   Schermuly RT, 2011, NAT REV CARDIOL, V8, P443, DOI 10.1038/nrcardio.2011.87
   SCHOEFFTER P, 1987, BIOCHEM PHARMACOL, V36, P3965, DOI 10.1016/0006-2952(87)90465-5
   Schulz E, 2008, ANTIOXID REDOX SIGN, V10, P1115, DOI 10.1089/ars.2007.1989
   Scipioni A, 2009, J BIOMED BIOTECHNOL, DOI 10.1155/2009/932961
   Senoner T, 2020, HEART, V106, P1040, DOI 10.1136/heartjnl-2020-316717
   Shapiro SD, 1998, CURR OPIN CELL BIOL, V10, P602, DOI 10.1016/S0955-0674(98)80035-5
   Sharma B, 2013, PHARMACOL BIOCHEM BE, V103, P821, DOI 10.1016/j.pbb.2012.11.011
   Silver FH, 2001, CRIT REV BIOMED ENG, V29, P279, DOI 10.1615/CritRevBiomedEng.v29.i3.10
   SINGH S, 1995, J BIOL CHEM, V270, P24995, DOI 10.1074/jbc.270.42.24995
   Singh VP, 2014, KOREAN J PHYSIOL PHA, V18, P1, DOI 10.4196/kjpp.2014.18.1.1
   Skoczynska A, 2005, HUM EXP TOXICOL, V24, P353, DOI 10.1191/0960327105ht536oa
   Soares MP, 2004, J IMMUNOL, V172, P3553, DOI 10.4049/jimmunol.172.6.3553
   Soetikno V, 2011, MOL NUTR FOOD RES, V55, P1655, DOI 10.1002/mnfr.201100080
   Soetikno V, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-35
   Solà E, 2010, HEPATOLOGY, V52, P1783, DOI 10.1002/hep.23893
   Sompamit K, 2010, TOXICOL LETT, V198, P77, DOI 10.1016/j.toxlet.2010.04.007
   Sompamit K, 2009, EUR J PHARMACOL, V616, P192, DOI 10.1016/j.ejphar.2009.06.014
   Somparn P, 2007, BIOL PHARM BULL, V30, P74, DOI 10.1248/bpb.30.74
   Sreejayan, 1997, J PHARM PHARMACOL, V49, P105, DOI 10.1111/j.2042-7158.1997.tb06761.x
   Srivastava G, 2009, J CARDIOVASC PHARM T, V14, P22, DOI 10.1177/1074248408329608
   Strimpakos AS, 2008, ANTIOXID REDOX SIGN, V10, P511, DOI 10.1089/ars.2007.1769
   Sunagawa Y., 2011, CIRCULATION, V75, P2150
   Suphim B, 2010, FOOD CHEM TOXICOL, V48, P2265, DOI 10.1016/j.fct.2010.05.059
   Suresh D, 2010, INDIAN J MED RES, V131, P682
   Tajsic T, 2011, COMPR PHYSIOL, V1, P295, DOI 10.1002/cphy.c100026
   Tapia E, 2012, OXID MED CELL LONGEV, V2012, DOI 10.1155/2012/269039
   Tellez-Plaza M, 2008, ENVIRON HEALTH PERSP, V116, P51, DOI 10.1289/ehp.10764
   Thimmulappa RK, 2006, J CLIN INVEST, V116, P984, DOI 10.1172/JCI25790
   Tian XY, 2012, CIRC RES, V110, P1211, DOI [10.1161/CIRCRESAHA.111.262170, 10.1161/circresaha.111.262170]
   Toth P, 2015, AGING CELL, V14, P1034, DOI 10.1111/acel.12372
   Touyz RM, 2004, HISTOCHEM CELL BIOL, V122, P339, DOI 10.1007/s00418-004-0696-7
   Trujillo J, 2013, REDOX BIOL, V1, P448, DOI 10.1016/j.redox.2013.09.003
   Ungvari Z, 2003, CIRCULATION, V108, P1253, DOI 10.1161/01.CIR.0000079165.84309.4D
   van der Loo B, 2000, J EXP MED, V192, P1731, DOI 10.1084/jem.192.12.1731
   Versari D, 2009, BRIT J PHARMACOL, V157, P527, DOI 10.1111/j.1476-5381.2009.00240.x
   Waisberg M, 2003, TOXICOLOGY, V192, P95, DOI 10.1016/S0300-483X(03)00305-6
   Walter A, 2008, J VASC RES, V45, P386, DOI 10.1159/000121408
   Wang J, 2012, INFLAMMATION, V35, P859, DOI 10.1007/s10753-011-9387-4
   Wang YD, 2004, FREE RADICAL BIO MED, V36, P1434, DOI 10.1016/j.freeradbiomed.2004.03.010
   Washington Benny, 2006, Int J Environ Res Public Health, V3, P323, DOI 10.3390/ijerph2006030040
   Wedgwood S, 2005, AM J PHYSIOL-LUNG C, V288, pL480, DOI 10.1152/ajplung.00283.2004
   Wikiera-Magott Irena, 2005, Wiad Lek, V58 Suppl 1, P50
   Willis A I, 2004, Vasc Endovascular Surg, V38, P11, DOI 10.1177/153857440403800102
   Wong SL, 2011, ARTERIOSCL THROM VAS, V31, P1169, DOI 10.1161/ATVBAHA.110.216044
   Wong TY, 2001, SURV OPHTHALMOL, V46, P59, DOI 10.1016/S0039-6257(01)00234-X
   Wong WT, 2010, CIRC RES, V107, P984, DOI 10.1161/CIRCRESAHA.110.222794
   Wongcharoen W, 2009, INT J CARDIOL, V133, P145, DOI 10.1016/j.ijcard.2009.01.073
   Wongeakin N, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/161346
   Wu F, 2008, J CELL PHYSIOL, V217, P207, DOI 10.1002/jcp.21495
   [谢骏 Xie Jun], 2014, [上海交通大学学报. 医学版, Journal of Shanghai Jiaotong University .Medical Science], V34, P1737
   Xie ZL, 2008, DIABETES, V57, P3222, DOI 10.2337/db08-0610
   Xu PH, 2007, VASC PHARMACOL, V47, P25, DOI 10.1016/j.vph.2007.03.003
   Yang Y, 2013, CELL SIGNAL, V25, P615, DOI 10.1016/j.cellsig.2012.11.025
   Yao QY, 2013, TOXICOL LETT, V222, P72, DOI 10.1016/j.toxlet.2013.06.240
   Yao YG, 2016, SCI REP-UK, V6, DOI 10.1038/srep25579
   Yoopan N, 2008, TOXICOL LETT, V176, P157, DOI 10.1016/j.toxlet.2007.11.002
   Zachary I, 2001, CARDIOVASC RES, V49, P568, DOI 10.1016/S0008-6363(00)00268-6
   Zalba G, 2001, HYPERTENSION, V38, P1395, DOI 10.1161/hy1201.099611
   Zhang F, 2014, J CELL MOL MED, V18, P1392, DOI 10.1111/jcmm.12286
   Zhang L, 2008, ACTA PHARMACOL SIN, V29, P800, DOI [10.1111/j.1745-7254.2008.00813.x, 10.1111/j.1745-7254.2008.00803.x]
   Zhao HG, 2010, TOXICOL LETT, V192, P356, DOI 10.1016/j.toxlet.2009.11.011
   Zhou HY, 2011, CURR DRUG TARGETS, V12, P332, DOI 10.2174/138945011794815356
   Zhuang XD, 2016, DRUG DES DEV THER, V10, DOI 10.2147/DDDT.S96315
NR 285
TC 11
Z9 11
U1 4
U2 25
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD OCT
PY 2022
VL 477
IS 10
BP 2359
EP 2385
DI 10.1007/s11010-022-04447-8
EA MAY 2022
PG 27
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 4S0LJ
UT WOS:000795769800001
PM 35569080
DA 2025-06-11
ER

PT J
AU Guleria, A
   Chandna, S
AF Guleria, Ayushi
   Chandna, Sudhir
TI ATM kinase: Much more than a DNA damage responsive protein
SO DNA REPAIR
LA English
DT Review
DE DNA damage; ATM activation; Oxidative stress; Metabolic syndrome;
   Neurodegenration
ID DOUBLE-STRAND BREAKS; GROWTH-FACTOR-I; ATAXIA-TELANGIECTASIA GENE;
   S-PHASE CHECKPOINT; OXIDATIVE STRESS; DEFICIENT MICE;
   IONIZING-RADIATION; SIGNALING PATHWAYS; G(2) CHECKPOINT; MITOCHONDRIAL
   DYSFUNCTION
AB ATM, mutation of which causes Ataxia telangiectasia, has emerged as a cardinal multifunctional protein kinase during past two decades as evidenced by various studies from around the globe. Further to its well established and predominant role in DNA damage response, ATM has also been understood to help in maintaining overall functional integrity of cells; since its mutation, inactivation or deficiency results in a variety of pathological manifestations besides DNA damage. These include oxidative stress, metabolic syndrome, mitochondrial dysfunction as well as neurodegeneration. Recently, high throughput screening using proteomics, metabolomics and transcriptomic studies revealed several proteins which might be acting as substrates of ATM. Studies that can help in identifying effective regulatory controls within the ATM-mediated pathways/mechanisms can help in developing better therapeutics. In fact, more in-depth understanding of ATM-dependent cellular signals could also help in the treatment of variety of other disease conditions since these pathways seem to control many critical cellular functions. In this review, we have attempted to put together a detailed yet lucid picture of the present-day understanding of ATM's role in various pathophysiological conditions involving DNA damage and beyond. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Guleria, Ayushi; Chandna, Sudhir] Inst Nucl Med & Allied Sci, Div Nat Radiat Response Mech, Delhi 110054, India.
C3 Defence Research & Development Organisation (DRDO); Institute of Nuclear
   Medicine & Allied Sciences (INMAS)
RP Chandna, S (corresponding author), Inst Nucl Med & Allied Sci, Div Nat Radiat Response Mech, Delhi 110054, India.
EM sudhirchandna@yahoo.com
RI Chandna, Sudhir/HPD-6329-2023
OI Chandna, Sudhir/0000-0001-8210-5786
FU Defence Research and Development Organization (DRDO) [INM-311-1-5,
   TD-15/INM-313]
FX We wish to thank the Defence Research and Development Organization
   (DRDO) for providing financial support through projects INM-311-1-5 and
   TD-15/INM-313.
CR Aguilar-Quesada R, 2007, BMC MOL BIOL, V8, DOI 10.1186/1471-2199-8-29
   Ahel D, 2009, SCIENCE, V325, P1240, DOI 10.1126/science.1177321
   Alexander A, 2010, P NATL ACAD SCI USA, V107, P4153, DOI 10.1073/pnas.0913860107
   Ali A, 2004, GENE DEV, V18, P249, DOI 10.1101/gad.1176004
   Allen DR, 2001, GENE DEV, V15, P554, DOI 10.1101/gad.869001
   Ambrose M, 2007, HUM MOL GENET, V16, P2154, DOI 10.1093/hmg/ddm166
   Andegeko Y, 2001, J BIOL CHEM, V276, P38224
   Armata HL, 2010, MOL CELL BIOL, V30, P5787, DOI 10.1128/MCB.00347-10
   Bakkenist CJ, 2003, NATURE, V421, P499, DOI 10.1038/nature01368
   BAR RS, 1978, NEW ENGL J MED, V298, P1164, DOI 10.1056/NEJM197805252982103
   Barlow C, 1996, CELL, V86, P159, DOI 10.1016/S0092-8674(00)80086-0
   Barzilai A, 2002, DNA REPAIR, V1, P3, DOI 10.1016/S1568-7864(01)00007-6
   Bhoumik A, 2008, J BIOL CHEM, V283, P17605, DOI 10.1074/jbc.M802030200
   Bin W, 2007, P NATL ACAD SCI USA, V104, P20759, DOI 10.1073/pnas.0710061104
   BODER E, 1958, PEDIATRICS, V21, P526
   Boder E, 1963, LITTLE CLUB CLIN DEV, V8, P110
   Boder E., 1957, U S CALIFORNIA MED B, V9
   Boisvert FM, 2005, CELL CYCLE, V4, P1834, DOI 10.4161/cc.4.12.2250
   Boisvert FM, 2005, CELL CYCLE, V4, P981, DOI 10.4161/cc.4.7.1830
   Botuyan MV, 2006, CELL, V127, P1361, DOI 10.1016/j.cell.2006.10.043
   Browne SE, 2004, FREE RADICAL BIO MED, V36, P938, DOI 10.1016/j.freeradbiomed.2004.01.003
   Carlessi L, 2009, CELL DEATH DIFFER, V16, P795, DOI 10.1038/cdd.2009.10
   Carney JP, 1998, CELL, V93, P477, DOI 10.1016/S0092-8674(00)81175-7
   Carro E, 2003, MOL NEUROBIOL, V27, P153, DOI 10.1385/MN:27:2:153
   Carrozza MJ, 2003, TRENDS GENET, V19, P321, DOI 10.1016/S0168-9525(03)00115-X
   Castellví-Bel S, 1999, HUM MUTAT, V14, P156, DOI 10.1002/(SICI)1098-1004(1999)14:2<156::AID-HUMU7>3.0.CO;2-E
   Chen C, 2009, CELL CYCLE, V8, P1158, DOI 10.4161/cc.8.8.8139
   Chen P, 2003, J NEUROSCI, V23, P11453
   Chen YM, 2001, J NEUROCHEM, V77, P1601, DOI 10.1046/j.1471-4159.2001.00374.x
   Cheng Q, 2009, EMBO J, V28, P3857, DOI 10.1038/emboj.2009.294
   Chou DM, 2010, P NATL ACAD SCI USA, V107, P18475, DOI 10.1073/pnas.1012946107
   Cook PJ, 2009, NATURE, V458, P591, DOI 10.1038/nature07849
   Cosentino C, 2011, EMBO J, V30, P546, DOI 10.1038/emboj.2010.330
   Cunningham JT, 2007, NATURE, V450, P736, DOI 10.1038/nature06322
   de Jager M, 2001, MOL CELL, V8, P1129, DOI 10.1016/S1097-2765(01)00381-1
   DEAN SW, 1988, CANCER RES, V48, P5374
   DENG CX, 1995, CELL, V82, P675, DOI 10.1016/0092-8674(95)90039-X
   Desagher S, 1996, J NEUROSCI, V16, P2553
   Desai-Mehta A, 2001, MOL CELL BIOL, V21, P2184, DOI 10.1128/MCB.21.6.2184-2191.2001
   Doil C, 2009, CELL, V136, P435, DOI 10.1016/j.cell.2008.12.041
   Du LT, 2009, J EXP MED, V206, P2285, DOI 10.1084/jem.20081940
   Eaton JS, 2007, J CLIN INVEST, V117, P2723, DOI 10.1172/JCI31604
   Falck J, 2005, NATURE, V434, P605, DOI 10.1038/nature03442
   Flatt PM, 2000, MOL CELL BIOL, V20, P4210, DOI 10.1128/MCB.20.12.4210-4223.2000
   Flynn A, 1996, CANCER SURV, V27, P293
   Fu XA, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002009
   GATTI RA, 1988, NATURE, V336, P577, DOI 10.1038/336577a0
   Gontijo AMDC, 2003, BIOCHIMIE, V85, P1133, DOI 10.1016/j.biochi.2003.10.018
   Goodarzi AA, 2004, EMBO J, V23, P4451, DOI 10.1038/sj.emboj.7600455
   Gueven N, 2006, FREE RADICAL BIO MED, V41, P992, DOI 10.1016/j.freeradbiomed.2006.06.018
   Guo Z, 2010, SCIENCE, V330, P517, DOI 10.1126/science.1192912
   Gupta A, 2005, MOL CELL BIOL, V25, P5292, DOI 10.1128/MCB.25.12.5292-5305.2005
   Hardie DG, 2006, J PHYSIOL-LONDON, V574, P7, DOI 10.1113/jphysiol.2006.108944
   Huyen Y, 2004, NATURE, V432, P406, DOI 10.1038/nature03114
   Innocente SA, 1999, P NATL ACAD SCI USA, V96, P2147, DOI 10.1073/pnas.96.5.2147
   Jin SQ, 2002, ONCOGENE, V21, P8696, DOI 10.1038/sj.onc.1206034
   Jung MR, 2012, ADV EXP MED BIOL, V720, P181, DOI 10.1007/978-1-4614-0254-1_15
   Kamsler A, 2001, CANCER RES, V61, P1849
   Kanu N, 2007, EMBO J, V26, P2933, DOI 10.1038/sj.emboj.7601733
   Kanu N, 2010, J BIOL CHEM, V285, P38534, DOI 10.1074/jbc.M110.145896
   Kastan MB, 2001, ACTA ONCOL, V40, P686
   Kim H, 2007, NAT STRUCT MOL BIOL, V14, P710, DOI 10.1038/nsmb1277
   Kim J, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016615
   Kim J, 2009, J BIOL CHEM, V284, P14396, DOI 10.1074/jbc.M808116200
   Kitagawa R, 2004, GENE DEV, V18, P1423, DOI 10.1101/gad.1200304
   Kolas NK, 2007, SCIENCE, V318, P1637, DOI 10.1126/science.1150034
   Kozlov S, 2003, J BIOL CHEM, V278, P9309, DOI 10.1074/jbc.M300003200
   Kozlov SV, 2006, EMBO J, V25, P3504, DOI 10.1038/sj.emboj.7601231
   Kozlov SV, 2011, J BIOL CHEM, V286, P9107, DOI 10.1074/jbc.M110.204065
   Krüger A, 2011, SCI SIGNAL, V4, DOI 10.1126/scisignal.2001959
   Lai CH, 2004, P NATL ACAD SCI USA, V101, P15676, DOI 10.1073/pnas.0405155101
   LANGE E, 1995, AM J HUM GENET, V57, P112
   Lee JH, 2005, SCIENCE, V308, P551, DOI 10.1126/science.1108297
   Lee SA, 2001, J BIOL CHEM, V276, P11783, DOI 10.1074/jbc.M004517200
   Lee Y, 2000, GENE DEV, V14, P2576, DOI 10.1101/gad.837100
   Lee Y, 2001, J NEUROSCI, V21, P6687, DOI 10.1523/JNEUROSCI.21-17-06687.2001
   Legube G, 2002, EMBO J, V21, P1704, DOI 10.1093/emboj/21.7.1704
   Li XZ, 2010, MOL CELL BIOL, V30, P5335, DOI 10.1128/MCB.00350-10
   Lim DS, 2000, NATURE, V404, P613, DOI 10.1038/35007091
   LIU JP, 1993, CELL, V75, P59, DOI 10.1016/0092-8674(93)90679-K
   Liu N, 2005, LAB INVEST, V85, P1471, DOI 10.1038/labinvest.3700354
   Llorca O, 2003, ONCOGENE, V22, P3867, DOI 10.1038/sj.onc.1206649
   Lu XB, 2005, CELL CYCLE, V4, P1060
   Lukas J, 2011, NAT CELL BIOL, V13, P1161, DOI 10.1038/ncb2344
   Mailand N, 2000, SCIENCE, V288, P1425, DOI 10.1126/science.288.5470.1425
   Mailand N, 2007, CELL, V131, P887, DOI 10.1016/j.cell.2007.09.040
   Matsuoka S, 2007, SCIENCE, V316, P1160, DOI 10.1126/science.1140321
   McBride HM, 2006, CURR BIOL, V16, pR551, DOI 10.1016/j.cub.2006.06.054
   Melixetian M, 2009, NAT CELL BIOL, V11, P1247, DOI 10.1038/ncb1969
   Miles PD, 2007, AM J PHYSIOL-ENDOC M, V293, pE70, DOI 10.1152/ajpendo.00259.2006
   Moon SH, 2010, CELL CYCLE, V9, P2092, DOI 10.4161/cc.9.11.11810
   Paull TT, 1998, MOL CELL, V1, P969, DOI 10.1016/S1097-2765(00)80097-0
   Pei HD, 2011, NATURE, V470, P124, DOI 10.1038/nature09658
   Peng CY, 1997, SCIENCE, V277, P1501, DOI 10.1126/science.277.5331.1501
   Peretz S, 2001, P NATL ACAD SCI USA, V98, P1676, DOI 10.1073/pnas.041416598
   Perlman Susan L, 2012, Handb Clin Neurol, V103, P307, DOI 10.1016/B978-0-444-51892-7.00019-X
   Perry J, 2003, CELL, V112, P151, DOI 10.1016/S0092-8674(03)00033-3
   Plans V, 2006, J CELL BIOCHEM, V97, P572, DOI 10.1002/jcb.20587
   Rass U, 2007, CELL, V130, P991, DOI 10.1016/j.cell.2007.08.043
   Reichenbach J, 1999, CLIN EXP IMMUNOL, V117, P535
   Reichenbach J, 2002, ANTIOXID REDOX SIGN, V4, P465, DOI 10.1089/15230860260196254
   Reliene R, 2004, CANCER RES, V64, P5148, DOI 10.1158/0008-5472.CAN-04-0442
   Reliene R, 2008, FOOD CHEM TOXICOL, V46, P1371, DOI 10.1016/j.fct.2007.08.028
   Rogakou EP, 1999, J CELL BIOL, V146, P905, DOI 10.1083/jcb.146.5.905
   Rogakou EP, 1998, J BIOL CHEM, V273, P5858, DOI 10.1074/jbc.273.10.5858
   Ruf A, 1996, P NATL ACAD SCI USA, V93, P7481, DOI 10.1073/pnas.93.15.7481
   Saito S, 2002, J BIOL CHEM, V277, P12491, DOI 10.1074/jbc.C200093200
   Sancar A, 2004, ANNU REV BIOCHEM, V73, P39, DOI 10.1146/annurev.biochem.73.011303.073723
   Savic V, 2009, MOL CELL, V34, P298, DOI 10.1016/j.molcel.2009.04.012
   SCHALCH DS, 1970, NEW ENGL J MED, V282, P1396, DOI 10.1056/NEJM197006182822503
   Schneider JG, 2006, CELL METAB, V4, P377, DOI 10.1016/j.cmet.2006.10.002
   Schubert R, 2004, HUM MOL GENET, V13, P1793, DOI 10.1093/hmg/ddh189
   Shao G, 2009, P NATL ACAD SCI USA, V106, P3166, DOI 10.1073/pnas.0807485106
   Shiloh Y, 2003, NAT REV CANCER, V3, P155, DOI 10.1038/nrc1011
   SHILOH Y, 1982, EXP CELL RES, V140, P191, DOI 10.1016/0014-4827(82)90169-0
   Shreeram S, 2006, MOL CELL, V23, P757, DOI 10.1016/j.molcel.2006.07.010
   Sobhian B, 2007, SCIENCE, V316, P1198, DOI 10.1126/science.1139516
   Stewart GS, 1999, CELL, V99, P577, DOI 10.1016/S0092-8674(00)81547-0
   Stokes MP, 2007, P NATL ACAD SCI USA, V104, P19855, DOI 10.1073/pnas.0707579104
   Stucki M, 2005, CELL, V123, P1213, DOI 10.1016/j.cell.2005.09.038
   Sun YL, 2007, MOL CELL BIOL, V27, P8502, DOI 10.1128/MCB.01382-07
   Sun YL, 2010, CELL CYCLE, V9, P930, DOI 10.4161/cc.9.5.10931
   Sun YL, 2005, P NATL ACAD SCI USA, V102, P13182, DOI 10.1073/pnas.0504211102
   SWIFT M, 1986, AM J HUM GENET, V39, P573
   Takao N, 2000, FEBS LETT, V472, P133, DOI 10.1016/S0014-5793(00)01422-8
   Taniguchi T, 2002, CELL, V109, P459, DOI 10.1016/S0092-8674(02)00747-X
   Uziel T, 2003, EMBO J, V22, P5612, DOI 10.1093/emboj/cdg541
   Valentin-Vega YA, 2012, BLOOD, V119, P1490, DOI 10.1182/blood-2011-08-373639
   Viniegra JG, 2005, J BIOL CHEM, V280, P4029, DOI 10.1074/jbc.M410344200
   Watters D, 1999, J BIOL CHEM, V274, P34277, DOI 10.1074/jbc.274.48.34277
   Westermann B, 2010, NAT REV MOL CELL BIO, V11, P872, DOI 10.1038/nrm3013
   Xu B, 2002, CANCER RES, V62, P4588
   Xu B, 2001, MOL CELL BIOL, V21, P3445, DOI 10.1128/MCB.21.10.3445-3450.2001
   Yan J, 2007, CANCER RES, V67, P6647, DOI 10.1158/0008-5472.CAN-07-0924
   Yan QS, 2009, MOL CELL, V36, P110, DOI 10.1016/j.molcel.2009.08.019
   Yang DQ, 2000, NAT CELL BIOL, V2, P893, DOI 10.1038/35046542
   Yarden RI, 2002, NAT GENET, V30, P285, DOI 10.1038/ng837
   You ZS, 2005, MOL CELL BIOL, V25, P5363, DOI 10.1128/MCB.25.13.5363-5379.2005
   Yu XC, 2006, GENE DEV, V20, P1721, DOI 10.1101/gad.1431006
   Zhang N, 1998, ONCOGENE, V17, P811, DOI 10.1038/sj.onc.1202007
   Zhou KX, 2011, NAT GENET, V43, P117, DOI 10.1038/ng.735
   Ziv Y, 1997, ONCOGENE, V15, P159, DOI 10.1038/sj.onc.1201319
NR 142
TC 115
Z9 127
U1 2
U2 37
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1568-7864
EI 1568-7856
J9 DNA REPAIR
JI DNA Repair
PD MAR
PY 2016
VL 39
BP 1
EP 20
DI 10.1016/j.dnarep.2015.12.009
PG 20
WC Genetics & Heredity; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Toxicology
GA DH6YJ
UT WOS:000372937700001
PM 26777338
DA 2025-06-11
ER

PT J
AU Sircu, V
   Colesnic, SI
   Covantsev, S
   Corlateanu, O
   Sukhotko, A
   Popovici, C
   Corlateanu, A
AF Sircu, Victoria
   Colesnic, Silvia-Iaroslava
   Covantsev, Serghei
   Corlateanu, Olga
   Sukhotko, Anna
   Popovici, Cristian
   Corlateanu, Alexandru
TI The Burden of Comorbidities in Obstructive Sleep Apnea and the
   Pathophysiologic Mechanisms and Effects of CPAP
SO CLOCKS & SLEEP
LA English
DT Review
DE OSAS; CPAP; diabetes mellitus; hypertension; ischemic heart disease;
   stroke; renal failure
ID POSITIVE AIRWAY PRESSURE; CHRONIC KIDNEY-DISEASE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; CANCER INCIDENCE; BREAST-CANCER; ASSOCIATION; STROKE;
   RISK; DEPRESSION
AB Micro-arousals and the repeated desaturation of oxyhemoglobin, which are typical in obstructive sleep apnea syndrome (OSAS), have adverse effects on the health of patients, leading to a wide range of complications such as cardiovascular (arterial hypertension, pulmonary hypertension, chronic heart failure, arrhythmias, myocardial infarction), cerebrovascular (strokes), metabolic (insulin resistance, obesity, diabetes mellitus, metabolic syndrome), gastrointestinal (non-alcoholic liver disease), urinary (chronic renal failure), and neuropsychiatric complications as well as a wide range of malignancies. These, in turn, have multilateral effects on familial, occupational, and social life, as well as increasing the risks of road traffic accidents and accidents at the workplace. Awareness, timely screening, and the prevention of complications play important roles in diagnosing and treating comorbid conditions. This review focuses on comorbidities in OSAS and the effect of Continuous Positive Airway Pressure (CPAP) therapy on their prognoses.
C1 [Sircu, Victoria; Colesnic, Silvia-Iaroslava; Popovici, Cristian; Corlateanu, Alexandru] State Univ Med, Dept Internal Med, Div Pneumol & Allergol, Pharm Nicolae Testemitanu, MD-2004 Kishinev, Moldova.
   [Covantsev, Serghei] Botkin Hosp, Dept Clin Res & Dev, Moscow 125284, Russia.
   [Covantsev, Serghei] Botkin Hosp, Dept Emergency Med 76, Moscow 125284, Russia.
   [Corlateanu, Olga] State Univ Med, Dept Internal Med, Pharm Nicolae Testemitanu, MD-2004 Kishinev, Moldova.
   [Sukhotko, Anna] Botkin Hosp, Dept Gen Oncol 71, Moscow 125284, Russia.
RP Corlateanu, A (corresponding author), State Univ Med, Dept Internal Med, Div Pneumol & Allergol, Pharm Nicolae Testemitanu, MD-2004 Kishinev, Moldova.
EM sircu.victoria@yahoo.com; aroslavakolesnik@gmail.com;
   kovantsev.s.d@gmail.com; olga.corlateanu@usmf.md; syxotya26@yandex.ru;
   cris.popovici9@gmail.com; alexandru.corlateanu@usmf.md
RI Corlateanu, Olga/AAC-9828-2020; Corlateanu, Alexandru/ABO-2279-2022;
   Serghei, Covantev/H-9669-2019; Corlateanu, Alexandru/G-3509-2013
OI Serghei, Covantev/0000-0001-7236-5699; Corlateanu,
   Alexandru/0000-0002-3278-436X
CR Alexiev F, 2018, J THORAC DIS, V10, pS4244, DOI 10.21037/jtd.2018.12.66
   Aloia MS, 2005, SLEEP MED, V6, P115, DOI 10.1016/j.sleep.2004.09.003
   Altintas N, 2013, EUR RESPIR J, V42
   Andrade AG, 2018, J ALZHEIMERS DIS, V64, pS255, DOI 10.3233/JAD-179936
   Antza C, 2022, J ENDOCRINOL, V252, P125, DOI 10.1530/JOE-21-0155
   Baron KG, 2017, INT J OBESITY, V41, P203, DOI 10.1038/ijo.2016.194
   Beaudin AE, 2022, SLEEP, V45, DOI 10.1093/sleep/zsab267
   Becker HF, 1998, THORAX, V53, pS29, DOI 10.1136/thx.53.2008.S29
   Black HR, 1997, ARCH INTERN MED, V157, P2413
   Bonsignore MR, 2019, MULTIDISCIP RESP MED, V14, DOI 10.1186/s40248-019-0172-9
   Campos-Rodriguez F, 2013, AM J RESP CRIT CARE, V187, P99, DOI 10.1164/rccm.201209-1671OC
   Chang WP, 2014, SLEEP MED, V15, P1016, DOI 10.1016/j.sleep.2014.05.026
   Chen CY, 2020, SLEEP MED, V66, P15, DOI 10.1016/j.sleep.2019.02.016
   Chen JC, 2014, SLEEP MED, V15, P749, DOI 10.1016/j.sleep.2013.11.782
   Chen LD, 2018, CLIN RESPIR J, V12, P373, DOI 10.1111/crj.12554
   Chobanian AV, 2003, JAMA-J AM MED ASSOC, V289, P2560, DOI 10.1001/jama.289.19.2560
   Chou KT, 2012, AM J MED, V125, P374, DOI 10.1016/j.amjmed.2011.07.003
   Corlateanu A, 2017, BREATHE, V13, P137, DOI 10.1183/20734735.007717
   Digby JW, 2017, EUR RESPIR J, V50, DOI 10.1183/1393003.congress-2017.OA3210
   Djonlagic I, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0085918
   Dziewas R, 2007, J NEUROL NEUROSUR PS, V78, P295, DOI 10.1136/jnnp.2006.102806
   Einhorn Daniel, 2007, Endocr Pract, V13, P355
   Ejaz Shakir M, 2011, Innov Clin Neurosci, V8, P17
   Emamian F, 2016, FRONT AGING NEUROSCI, V8, DOI 10.3389/fnagi.2016.00078
   Emiley P., 2012, J EMERG MED, V43, P208, DOI [10.1016/j.jemermed.2012.05.026, DOI 10.1016/J.JEMERMED.2012.05.026]
   FLETCHER EC, 1985, ANN INTERN MED, V103, P190, DOI 10.7326/0003-4819-103-2-190
   FRANKLIN KA, 1995, LANCET, V345, P1085, DOI 10.1016/S0140-6736(95)90820-X
   Garvey JF, 2015, J THORAC DIS, V7, P920, DOI 10.3978/j.issn.2072-1439.2015.04.52
   Ghiasi F, 2017, J RES MED SCI, V22, DOI 10.4103/jrms.JRMS_523_16
   Good DC, 1996, STROKE, V27, P252, DOI 10.1161/01.STR.27.2.252
   Gottlieb DJ, 2010, CIRCULATION, V122, P352, DOI 10.1161/CIRCULATIONAHA.109.901801
   Gottlieb DJ, 2005, ARCH INTERN MED, V165, P863, DOI 10.1001/archinte.165.8.863
   Gozal D, 2016, SLEEP, V39, P1493, DOI 10.5665/sleep.6004
   Gozal D, 2016, SLEEP MED REV, V27, P43, DOI 10.1016/j.smrv.2015.05.006
   Gozal D, 2014, ONCOIMMUNOLOGY, V3, DOI 10.4161/onci.28326
   Guest JF, 2014, DIABETES CARE, V37, P1263, DOI 10.2337/dc13-2539
   Hakim F, 2014, CANCER RES, V74, P1329, DOI 10.1158/0008-5472.CAN-13-3014
   HANLY P, 1993, AM J CARDIOL, V71, P1341, DOI 10.1016/0002-9149(93)90552-N
   Hanly PJ, 2015, J CLIN SLEEP MED, V11, P845, DOI 10.5664/jcsm.4928
   Hersi AS, 2010, ANN THORAC MED, V5, P10, DOI 10.4103/1817-1737.58954
   Hirono H, 2021, WORLD J CLIN CASES, V9, P5112, DOI 10.12998/wjcc.v9.i19.5112
   Hobzova M, 2015, EUR RESPIR J, V46, DOI 10.1183/13993003.congress-2015.PA2332
   HOFFSTEIN V, 1994, CHEST, V106, P466, DOI 10.1378/chest.106.2.466
   Huang J, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.727959
   Hyun MK, 2019, BMC GASTROENTEROL, V19, DOI 10.1186/s12876-019-0945-9
   Ifergane G, 2016, STROKE, V47, P1207, DOI 10.1161/STROKEAHA.115.011749
   Kelly A, 2010, SLEEP, V33, P1185, DOI 10.1093/sleep/33.9.1185
   Kendzerska T, 2021, CANCER EPIDEM BIOMAR, V30, P295, DOI 10.1158/1055-9965.EPI-20-0975
   Kendzerska T, 2017, EUR RESPIR J, V49, DOI 10.1183/13993003.01361-2016
   Khanijow Vikesh, 2015, Gastroenterol Hepatol (N Y), V11, P817
   Kontogianni K, 2007, ENVIRON MOL MUTAGEN, V48, P722, DOI 10.1002/em.20351
   Koo Dae Lim, 2020, Journal of sleep medicine, V17, P73, DOI 10.13078/jsm.200008
   Koren D, 2011, DIABETES CARE, V34, P2442, DOI 10.2337/dc11-1093
   Lam JCM, 2010, EUR RESPIR J, V35, P138, DOI 10.1183/09031936.00047709
   Lee DB, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24054547
   Leproult R, 1997, SLEEP, V20, P865
   Li QJ, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-27784-0
   Lin CH, 2020, CHEST, V157, P673, DOI 10.1016/j.chest.2019.09.004
   Lin CH, 2018, CURR OPIN PULM MED, V24, P549, DOI 10.1097/MCP.0000000000000525
   Lüdemann P, 2001, J NEUROL NEUROSUR PS, V70, P685, DOI 10.1136/jnnp.70.5.685
   Luo JH, 2013, AM J EPIDEMIOL, V177, P42, DOI 10.1093/aje/kws193
   Marin-Oto M, 2019, MULTIDISCIP RESP MED, V14, DOI 10.1186/s40248-019-0186-3
   Marrone O, 2020, CURR SLEEP MED REP, V6, P85, DOI 10.1007/s40675-020-00176-w
   Marshall NS, 2014, J CLIN SLEEP MED, V10, P355, DOI 10.5664/jcsm.3600
   Masuda T, 2011, NEPHROL DIAL TRANSPL, V26, P2289, DOI 10.1093/ndt/gfq756
   Mayer P, 1999, AM J RESP CRIT CARE, V159, P213, DOI 10.1164/ajrccm.159.1.9709051
   McElroy JA, 2006, J SLEEP RES, V15, P241, DOI 10.1111/j.1365-2869.2006.00523.x
   Mesarwi OA, 2019, AM J RESP CRIT CARE, V199, P830, DOI 10.1164/rccm.201806-1109TR
   Narkiewicz K, 1999, CIRCULATION, V100, P2332, DOI 10.1161/01.CIR.100.23.2332
   Netzer N, 1998, STROKE, V29, P87, DOI 10.1161/01.STR.29.1.87
   Nicholl DDM, 2012, CHEST, V141, P1422, DOI 10.1378/chest.11-1809
   Odajiu I, 2022, RESP MED, V201, DOI 10.1016/j.rmed.2022.106952
   Olafiranye O, 2013, AM J RESP CRIT CARE, V188, P1394, DOI 10.1164/rccm.201310-1923ED
   Ozkok A, 2014, CLIN EXP HYPERTENS, V36, P211, DOI 10.3109/10641963.2013.804546
   Pack AI, 2006, AM J RESP CRIT CARE, V173, P7, DOI 10.1164/rccm.200509-1478OE
   Papanas N, 2009, VASC HEALTH RISK MAN, V5, P751
   Parati G, 2013, EUR RESPIR J, V41, P523, DOI 10.1183/09031936.00226711
   Peker Y, 2000, AM J RESP CRIT CARE, V162, P81, DOI 10.1164/ajrccm.162.1.9905035
   Peng YH, 2014, THROMB RES, V134, P340, DOI 10.1016/j.thromres.2014.06.009
   Peppard PE, 2000, NEW ENGL J MED, V342, P1378, DOI 10.1056/NEJM200005113421901
   Petta S, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0142210
   Porto F, 2017, ARQ BRAS CARDIOL, V108, P361, DOI 10.5935/abc.20170031
   Rizza S, 2021, ACTA DIABETOL, V58, P1111, DOI 10.1007/s00592-021-01676-z
   Rizza S, 2020, NUTR METAB CARDIOVAS, V30, P1826, DOI 10.1016/j.numecd.2020.05.028
   Rofstad EK, 2010, INT J CANCER, V127, P1535, DOI 10.1002/ijc.25176
   Rossi VA, 2013, EUR RESPIR J, V41, P1439, DOI 10.1183/09031936.00128412
   Schroder Carmen M, 2005, Ann Gen Psychiatry, V4, P13, DOI 10.1186/1744-859X-4-13
   Shahar E, 2001, AM J RESP CRIT CARE, V163, P19, DOI 10.1164/ajrccm.163.1.2001008
   Shamsuzzaman ASM, 2003, JAMA-J AM MED ASSOC, V290, P1906, DOI 10.1001/jama.290.14.1906
   Sharma S, 2016, STROKE VASC NEUROL, V1, P185, DOI 10.1136/svn-2016-000038
   Shoib S, 2017, J NEUROSCI RURAL PRA, V8, P346, DOI 10.4103/jnrp.jnrp_462_16
   Sillah A, 2018, CANCER CAUSE CONTROL, V29, P987, DOI 10.1007/s10552-018-1073-5
   Taheri S, 2004, PLOS MED, V1, P210, DOI 10.1371/journal.pmed.0010062
   Tan MMC, 2022, J CLIN MED, V11, DOI 10.3390/jcm11154466
   Tatti Patrizio, 2013, J Diabetes Sci Technol, V7, P743
   Tosun A, 2008, CLINICS, V63, P625, DOI 10.1590/S1807-59322008000500010
   West SD, 2006, THORAX, V61, P945, DOI 10.1136/thx.2005.057745
   West SD, 2007, THORAX, V62, P969, DOI 10.1136/thx.2006.074351
   Whelton PK, 2018, JAMA-J AM MED ASSOC, V320, P1749, DOI 10.1001/jama.2018.16755
   Xu PH, 2019, CHEST, V156, P743, DOI 10.1016/j.chest.2019.04.130
   Yagihara F, 2012, CLINICS, V67, P565, DOI 10.6061/clinics/2012(06)04
   Yamauchi M, 2005, CHEST, V127, P1674, DOI 10.1378/chest.127.5.1674
   Yeh NC, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000002293
   YOUNG T, 1993, NEW ENGL J MED, V328, P1230, DOI 10.1056/NEJM199304293281704
   Yu K, 2018, EUR REV MED PHARMACO, V22, P4261, DOI 10.26355/eurrev_201807_15422
   Zamarrón E, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-85023-w
   Zozina VI, 2021, COPD, V18, P114, DOI 10.1080/15412555.2020.1849084
NR 107
TC 16
Z9 17
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2624-5175
J9 CLOCKS SLEEP
JI Clocks Sleep
PD JUN
PY 2023
VL 5
IS 2
BP 333
EP 349
DI 10.3390/clockssleep5020025
PG 17
WC Clinical Neurology; Neurosciences
WE Emerging Sources Citation Index (ESCI)
SC Neurosciences & Neurology
GA K1TO8
UT WOS:001014340600001
PM 37366660
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Lai, YC
   Yew, YW
AF Lai, Yi Chun
   Yew, Yik Weng
TI Psoriasis as an Independent Risk Factor for Cardiovascular Disease: An
   Epidemiologic Analysis Using a National Database
SO JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
LA English
DT Article
DE psoriasis; dermatology; inflammatory dermatoses
ID MYOCARDIAL-INFARCTION; OXIDATIVE STRESS; PLAQUE PSORIASIS; ALCOHOL;
   EVENTS; COHORT; ATHEROSCLEROSIS; METAANALYSIS; MORTALITY; SMOKING
AB Background: Psoriasis is known to be associated with metabolic syndrome, a well-established risk factor for ischemic heart disease and stroke. Emerging evidence indicates that psoriasis is an independent risk factor for cardiovascular disease and stroke.
   Objective: To evaluate whether psoriasis is independently associated with myocardial infarction (MI), ischemic heart disease (MI, angina pectoris, or coronary heart disease), and stroke, we conducted a cross-sectional study using the US National Health and Nutrition Examination Survey (NHANES) database.
   Methods: Data on clinical history of psoriasis, MI, angina pectoris, coronary heart disease, and stroke from the questionnaire as well as laboratory parameters on serum lipid and uric acid levels in the cycle years 2003-2006 and 2009-2012 were analyzed. Multivariate analysis with logistic regression modelling was performed with the aforementioned cardiovascular events or stroke as the dependent variables and with risk factors such as age, gender, ethnic group, current smoking status, alcohol consumption, metabolic syndrome, hyperuricemia, and psoriasis as independent variables.
   Results: There were 520 cases of psoriasis, and 108 of them had metabolic syndrome (20.8%). Well-established cardiovascular risk factors such as age, gender, ethnic group, smoking, alcohol consumption, metabolic syndrome, and hyperuricemia were also found to have significant associations with MI and ischemic heart disease (all P values <.001). Psoriatic patients were at significantly higher risks of developing MI (odds ratio [OR] 2.24; 95% CI: 1.27-3.95; P = .005) and ischemic heart disease (OR 1.90; 95% CI: 1.18-3.05; P = .008), but not stroke (OR 1.01; 95% CI: 0.48-2.16; P = .744), after adjustment was made for major cardiovascular risk factors.
   Conclusion: This study provides epidemiological evidence that psoriasis may be independently associated with the development of MI and ischemic heart disease. Physicians should be cognizant of any underlying cardiovascular risk factors, especially among psoriatic patients with metabolic syndrome, and manage them according to national guidelines.
C1 [Lai, Yi Chun; Yew, Yik Weng] Harvard Univ, TH Chan Sch Publ Hlth, Boston, MA 02115 USA.
   [Yew, Yik Weng] Natl Skin Ctr, 1 Mandalay Rd, Singapore 308205, Singapore.
C3 Harvard University; Harvard T.H. Chan School of Public Health; National
   Skin Centre
RP Yew, YW (corresponding author), Natl Skin Ctr, 1 Mandalay Rd, Singapore 308205, Singapore.
EM yikweng.yew@mail.harvard.edu
RI Weng, Yew/AGQ-4775-2022
OI Yew, Yik Weng/0000-0001-8915-306X
CR Ahlehoff O, 2011, J INTERN MED, V270, P147, DOI 10.1111/j.1365-2796.2010.02310.x
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Boehncke WH, 2011, EXP DERMATOL, V20, P303, DOI 10.1111/j.1600-0625.2011.01261.x
   Brauchli YB, 2009, BRIT J DERMATOL, V160, P1048, DOI 10.1111/j.1365-2133.2008.09020.x
   Butler R, 2000, HYPERTENSION, V35, P746, DOI 10.1161/01.HYP.35.3.746
   Chen JH, 2012, CLIN RHEUMATOL, V31, P239, DOI 10.1007/s10067-011-1802-6
   Davidovici BB, 2010, J INVEST DERMATOL, V130, P1785, DOI 10.1038/jid.2010.103
   Dhingra S, 2007, AM J PHYSIOL-HEART C, V293, pH3524, DOI 10.1152/ajpheart.00919.2007
   Dommasch ED, 2013, J AM ACAD DERMATOL, V68, P863, DOI 10.1016/j.jaad.2013.01.011
   Dowlatshahi EA, 2013, J INVEST DERMATOL, V133, P2347, DOI 10.1038/jid.2013.131
   Gelfand JM, 2006, JAMA-J AM MED ASSOC, V296, P1735, DOI 10.1001/jama.296.14.1735
   Gisondi P, 2009, DERMATOLOGY, V218, P110, DOI 10.1159/000182256
   Grundy SM, 2005, CIRCULATION, V112, pE285, DOI 10.1161/CIRCULATIONAHA.105.169405
   Hashmi S, 2006, CORONARY ARTERY DIS, V17, P699, DOI 10.1097/01.mca.0000236288.94553.b4
   Jousilahti P, 1999, CIRCULATION, V99, P1165, DOI 10.1161/01.cir.99.9.1165
   Kaye JA, 2008, BRIT J DERMATOL, V159, P895, DOI 10.1111/j.1365-2133.2008.08707.x
   Li WQ, 2012, BRIT J DERMATOL, V166, P811, DOI 10.1111/j.1365-2133.2011.10774.x
   Libby P, 2011, NATURE, V473, P317, DOI 10.1038/nature10146
   Lin HW, 2011, J AM ACAD DERMATOL, V64, P495, DOI 10.1016/j.jaad.2010.01.050
   Ludwig RJ, 2007, BRIT J DERMATOL, V156, P271, DOI 10.1111/j.1365-2133.2006.07562.x
   Matsumoto C, 2014, J CARDIOPULM REHABIL, V34, P159, DOI 10.1097/HCR.0000000000000042
   McAleer MA, 2011, BRIT J DERMATOL, V164, P1256, DOI 10.1111/j.1365-2133.2011.10345.x
   Mercuro G, 2004, AM J CARDIOL, V94, P932, DOI 10.1016/j.amjcard.2004.06.032
   Miller IM, 2013, J AM ACAD DERMATOL, V69, P1014, DOI 10.1016/j.jaad.2013.06.053
   Neimann AL, 2006, J AM ACAD DERMATOL, V55, P829, DOI 10.1016/j.jaad.2006.08.040
   Parisi R, 2015, J INVEST DERMATOL, V135, P2189, DOI 10.1038/jid.2015.87
   Pietrzak A, 2013, INT J DERMATOL, V52, P153, DOI 10.1111/j.1365-4632.2012.05584.x
   Poikolainen K, 1999, ARCH DERMATOL, V135, P1490, DOI 10.1001/archderm.135.12.1490
   Rachakonda TD, 2014, J AM ACAD DERMATOL, V70, P512, DOI 10.1016/j.jaad.2013.11.013
   Rocha-Pereira P, 2001, CLIN CHIM ACTA, V303, P33, DOI 10.1016/S0009-8981(00)00358-2
   Ryan C, 2015, DERMATOL CLIN, V33, P41, DOI 10.1016/j.det.2014.09.004
   Torii K, 2011, EXP DERMATOL, V20, P371, DOI 10.1111/j.1600-0625.2010.01224.x
   Tzellos T, 2013, J EUR ACAD DERMATOL, V27, P622, DOI 10.1111/j.1468-3083.2012.04500.x
   Wakkee M, 2007, ATHEROSCLEROSIS, V190, P1, DOI 10.1016/j.atherosclerosis.2006.07.011
   Wolk K, 2009, ACTA DERM-VENEREOL, V89, P492, DOI 10.2340/00015555-0711
   Wu JJ, J DERMATOLOG TREAT
   Zhao G, 2013, ATHEROSCLEROSIS, V231, P61, DOI 10.1016/j.atherosclerosis.2013.08.023
NR 37
TC 45
Z9 46
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1203-4754
EI 1615-7109
J9 J CUTAN MED SURG
JI J. Cutan. Med. Surg.
PD JUL-AUG
PY 2016
VL 20
IS 4
BP 327
EP 333
DI 10.1177/1203475415602842
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA DP5OA
UT WOS:000378545700008
PM 26316538
DA 2025-06-11
ER

PT J
AU Cho, KI
   Sakuma, I
   Sohn, IS
   Jo, SH
   Koh, KK
AF Cho, Kyoung Im
   Sakuma, Ichiro
   Sohn, Il Suk
   Jo, Sang-Ho
   Koh, Kwang Kon
TI Inflammatory and metabolic mechanisms underlying the calcific aortic
   valve disease
SO ATHEROSCLEROSIS
LA English
DT Review
DE Calcific aortic valve disease; Cardiometabolic risk factors;
   Inflammation; Oxidation; Ossification
ID ANGIOTENSIN-CONVERTING-ENZYME; OXIDATION-SPECIFIC BIOMARKERS;
   LOW-DENSITY-LIPOPROTEIN; VASCULAR CALCIFICATION; OXIDIZED PHOSPHOLIPIDS;
   ELEVATED LIPOPROTEIN(A); LP(A) LIPOPROTEIN; CLINICAL FACTORS; HUMAN
   CORONARY; STENOSIS
AB Although calcific aortic stenosis is a very common disease with major adverse cardiovascular events and healthcare costs, there are no effective medical interventions to delay or halt its progression. Cardiometabolic risk factors, including smoking and male sex, are linked to aortic stenosis. Emerging studies have identified important regulatory roles for immunological and inflammatory responses, including oxidized lipids, various cytokines, and biomineralization. Recent clinical and experimental studies in atherosclerosis and osteoporosis have demonstrated that oxidative stress and oxidized lipids decrease bone formation in the skeletal system while they increase bone formation in the cardiovascular system. Multidisciplinary factors contribute to vascular calcification, including inflammation and metabolic regulation of osteogenesis in the cardiovascular system via similar signaling pathways as bone formation.
   Calcific aortic valve disease (CAVD) is no longer considered a simple passive process of calcium deposition that occurs with advanced age. Biomineralization in CAVD is a complex, regulated process that involves valvular, circulating, bone marrow-derived cells, macrophage heterogeneity and genetic factors along with biochemical and mechanical factors. The current review will discuss the recently discovered important role of inflammation, metabolic risk factors, and molecular and cellular mechanisms that promote CAVD, as well as the link between osteogenic signals in the skeletal and cardiovascular systems. This may inform future therapeutic strategies for CAVD progression.
C1 [Cho, Kyoung Im] Kosin Univ, Gospel Hosp, Dept Cardiol, Busan, South Korea.
   [Sakuma, Ichiro] Hokko Mem Clin, Cardiovasc Med, Sapporo, Hokkaido, Japan.
   [Sakuma, Ichiro] Hlth Sci Univ Hokkaido, Tobetsu, Japan.
   [Sohn, Il Suk] Kyung Hee Univ Hosp Gangdong, Dept Cardiol, Cardiovasc Ctr, Seoul, South Korea.
   [Jo, Sang-Ho] Hanlym Univ Hosp Pyungchon, Dept Cardiol, Pyongchon, South Korea.
   [Koh, Kwang Kon] Gachon Univ, Gil Med Ctr, Dept Cardiovasc Med, Ctr Heart, Incheon, South Korea.
   [Koh, Kwang Kon] Gachon Cardiovasc Res Inst, Incheon, South Korea.
C3 Health Sciences University of Hokkaido; Kyung Hee University; Kyung Hee
   University Hospital; Gachon University
RP Koh, KK (corresponding author), Gachon Univ, Cardiometab Syndrome Unit, Dept Cardiovasc Med, Gil Med Ctr, 774 Beongil 21, Incheon 21565, South Korea.
EM kwangk@gilhospital.com
RI Cho, Young-Seok/J-5670-2012; SOHN, ILSUK/AAI-1097-2020
OI SOHN, IL SUK/0000-0001-8004-5185
FU Korea Health Industry Development Institute (KHIDI) - Ministry of Health
   and Welfare, Korea [HI15C0987, HI14C1135]; Korean Society of
   CardioMetabolic Syndrome
FX This work was supported by a grant from the Korea Health Technology R&D
   Project through the Korea Health Industry Development Institute (KHIDI)
   funded by the Ministry of Health and Welfare, Korea (HI15C0987 &
   HI14C1135) and the Korean Society of CardioMetabolic Syndrome.
CR Abedin M, 2006, CIRC RES, V98, P727, DOI 10.1161/01.RES.0000216009.68958.e6
   Abedin M, 2004, ARTERIOSCL THROM VAS, V24, P1161, DOI 10.1161/01.ATV.0000133194.94939.42
   Al Kindi M, 2017, CAN J CARDIOL, V33, P658, DOI 10.1016/j.cjca.2017.02.001
   Albanese I, 2017, ARTERIOSCL THROM VAS, V37, P543, DOI 10.1161/ATVBAHA.116.308394
   [Anonymous], GLOBAL CARDIOL SCI P
   Arsenault BJ, 2014, CIRC-CARDIOVASC GENE, V7, P304, DOI 10.1161/CIRCGENETICS.113.000400
   Awan Z, 2008, ARTERIOSCL THROM VAS, V28, P777, DOI 10.1161/ATVBAHA.107.160408
   Bittner V, 2016, CIRCULATION, V134, P1695, DOI 10.1161/CIRCULATIONAHA.116.023687
   Boonmark NW, 1997, CLIN GENET, V52, P355
   Capoulade R, 2015, J AM COLL CARDIOL, V66, P1236, DOI 10.1016/j.jacc.2015.07.020
   Chan KL, 2010, CIRCULATION, V121, P306, DOI 10.1161/CIRCULATIONAHA.109.900027
   Cho KI, 2018, CIRC J, V82, P937, DOI 10.1253/circj.CJ-17-1445
   Cho KI, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0161530
   Choi B, 2017, CIRCULATION, V135, P1935, DOI 10.1161/CIRCULATIONAHA.116.024270
   Clarke R, 2009, NEW ENGL J MED, V361, P2518, DOI 10.1056/NEJMoa0902604
   Côte C, 2008, HEART, V94, P1175, DOI 10.1136/hrt.2007.125740
   Cowell SJ, 2005, NEW ENGL J MED, V352, P2389, DOI 10.1056/NEJMoa043876
   Demer LL, 2014, ARTERIOSCL THROM VAS, V34, P715, DOI 10.1161/ATVBAHA.113.302070
   Dichtl W, 2008, AM J CARDIOL, V102, P743, DOI 10.1016/j.amjcard.2008.04.060
   Doyon M, 2013, CARDIOVASC RES, V97, P331, DOI 10.1093/cvr/cvs325
   Dweck MR, 2012, J AM COLL CARDIOL, V60, P1854, DOI 10.1016/j.jacc.2012.02.093
   Elder DHJ, 2013, EXPERT REV CARDIOVAS, V11, P107, DOI [10.1586/ERC.12.143, 10.1586/erc.12.143]
   EVERHART JE, 1988, DIABETOLOGIA, V31, P16
   Fadini GP, 2012, EXP DIABETES RES, DOI 10.1155/2012/921685
   Farhat GN, 2006, J BONE MINER RES, V21, P1839, DOI 10.1359/JBMR.060903
   Flammer AJ, 2012, J CLIN ENDOCR METAB, V97, P4761, DOI 10.1210/jc.2012-2642
   Garg V, 2005, NATURE, V437, P270, DOI 10.1038/nature03940
   Giachelli CM, 2017, ARTERIOSCL THROM VAS, V37, P387, DOI 10.1161/ATVBAHA.116.308842
   Goettsch C, 2017, ARTERIOSCL THROM VAS, V37, P1005, DOI 10.1161/ATVBAHA.116.308932
   Goettsch C, 2016, J CLIN INVEST, V126, P1323, DOI 10.1172/JCI80851
   Hak AE, 2000, ARTERIOSCL THROM VAS, V20, P1926, DOI 10.1161/01.ATV.20.8.1926
   Hodonsky CJ, 2017, CIRCULATION, V135
   Hung MY, 2014, J AM COLL CARDIOL, V63, P478, DOI 10.1016/j.jacc.2013.08.1639
   Hutcheson JD, 2015, SEMIN CELL DEV BIOL, V46, P68, DOI 10.1016/j.semcdb.2015.09.004
   Kamstrup PR, 2014, J AM COLL CARDIOL, V63, P470, DOI 10.1016/j.jacc.2013.09.038
   Kamstrup PR, 2012, ARTERIOSCL THROM VAS, V32, P1732, DOI 10.1161/ATVBAHA.112.248765
   Kamstrup PR, 2009, JAMA-J AM MED ASSOC, V301, P2331, DOI 10.1001/jama.2009.801
   Katz R, 2006, CIRCULATION, V113, P2113, DOI 10.1161/CIRCULATIONAHA.105.598086
   Koh KK, 2017, CIRCULATION, V136, P1668, DOI 10.1161/CIRCULATIONAHA.117.029815
   Koh KK, 2017, CIRCULATION, V135, pE1006, DOI 10.1161/CIRCULATIONAHA.116.026821
   Kurtz CE, 2010, MEDICINE, V89, P349, DOI 10.1097/MD.0b013e3181fe5648
   Lee CS, 2016, SCI REP-UK, V6, DOI 10.1038/srep29393
   Li X, 2015, J CELL BIOCHEM, V116, P2354, DOI 10.1002/jcb.25186
   Linefsky JP, 2011, J AM COLL CARDIOL, V58, P291, DOI 10.1016/j.jacc.2010.11.073
   Merryman WD, 2013, CURR CARDIOL REP, V15, DOI 10.1007/s11886-013-0355-5
   Mohty D, 2008, ARTERIOSCL THROM VAS, V28, P187, DOI 10.1161/ATVBAHA.107.154989
   Moura LM, 2007, J AM COLL CARDIOL, V49, P554, DOI 10.1016/j.jacc.2006.07.072
   Mundy G, 1999, SCIENCE, V286, P1946, DOI 10.1126/science.286.5446.1946
   Novaro GM, 2007, J AM COLL CARDIOL, V50, P1992, DOI 10.1016/j.jacc.2007.07.064
   O'Brien KD, 2002, CIRCULATION, V106, P2224, DOI 10.1161/01.CIR.0000035655.45453.D2
   OBrien KD, 1996, ARTERIOSCL THROM VAS, V16, P523, DOI 10.1161/01.ATV.16.4.523
   Oh PC, 2016, KOREAN J INTERN MED, V31, P237
   Otto CM, 2014, NEW ENGL J MED, V371, P744, DOI 10.1056/NEJMra1313875
   Owens DS, 2010, AM J CARDIOL, V105, P701, DOI 10.1016/j.amjcard.2009.10.071
   Ozkan J, 2017, EUR HEART J, V38, P2697, DOI 10.1093/eurheartj/ehx470
   Rajamannan NM, 2017, CAN J CARDIOL, V33, P594, DOI 10.1016/j.cjca.2017.03.001
   Rajamannan NM, 2011, CIRCULATION, V124, P1783, DOI 10.1161/CIRCULATIONAHA.110.006767
   Ravandi A, 2014, J AM COLL CARDIOL, V63, P1961, DOI 10.1016/j.jacc.2014.01.055
   Rogers MA, 2017, CIRC RES, V121, P220, DOI 10.1161/CIRCRESAHA.116.310293
   Rogers MA, 2017, CIRC RES, V121, P5, DOI 10.1161/CIRCRESAHA.117.311219
   Rossebo AB, 2008, NEW ENGL J MED, V359, P1343, DOI 10.1056/NEJMoa0804602
   Saremi A, 2012, DIABETES CARE, V35, P2390, DOI 10.2337/dc12-0464
   Schieffer B, 2000, CIRCULATION, V101, P1372, DOI 10.1161/01.CIR.101.12.1372
   Shavelle DM, 2002, LANCET, V359, P1125, DOI 10.1016/S0140-6736(02)08161-8
   Sinha A, 2013, DIABETES VASC DIS RE, V10, P410, DOI 10.1177/1479164113485101
   Stewart BF, 1997, J AM COLL CARDIOL, V29, P630, DOI 10.1016/S0735-1097(96)00563-3
   Thaden JJ, 2014, PROG CARDIOVASC DIS, V56, P565, DOI 10.1016/j.pcad.2014.02.006
   Thanassoulis G, 2013, NEW ENGL J MED, V368, P503, DOI 10.1056/NEJMoa1109034
   Tintut Y, 2004, ARTERIOSCL THROM VAS, V24, pE6, DOI 10.1161/01.ATV.0000112023.62695.7f
   Towler DA, 2013, CIRC RES, V113, P198, DOI 10.1161/CIRCRESAHA.113.300155
   Tsimikas S, 2005, NEW ENGL J MED, V353, P46, DOI 10.1056/NEJMoa043175
   Tsimikas S, 2014, J AM COLL CARDIOL, V63, P1724, DOI 10.1016/j.jacc.2013.12.030
   Tsimikas S, 2012, J AM COLL CARDIOL, V60, P2218, DOI 10.1016/j.jacc.2012.08.979
   Tsimikas S, 2010, J AM COLL CARDIOL, V56, P946, DOI 10.1016/j.jacc.2010.04.048
   van der Valk FM, 2016, CIRCULATION, V134, P611, DOI 10.1161/CIRCULATIONAHA.116.020838
   van Dijk RA, 2012, J LIPID RES, V53, P2773, DOI 10.1194/jlr.P030890
   Vattikuti R, 2004, AM J PHYSIOL-ENDOC M, V286, pE686, DOI 10.1152/ajpendo.00552.2003
   WATANABE Y, 1989, RHEUMATOL INT, V9, P25, DOI 10.1007/BF00270286
   Yutzey KE, 2014, ARTERIOSCL THROM VAS, V34, P2387, DOI 10.1161/ATVBAHA.114.302523
NR 79
TC 96
Z9 104
U1 0
U2 41
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD OCT
PY 2018
VL 277
BP 60
EP 65
DI 10.1016/j.atherosclerosis.2018.08.029
PG 6
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GV2HG
UT WOS:000445908000010
PM 30173080
DA 2025-06-11
ER

PT J
AU Muriel, P
   López-Sánchez, P
   Ramos-Tovar, E
AF Muriel, Pablo
   Lopez-Sanchez, Pedro
   Ramos-Tovar, Erika
TI Fructose and the Liver
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE liver; fructose; uric acid; NLRP3; oxidative stress; inflammation
ID NF-KAPPA-B; FATTY LIVER; OXIDATIVE STRESS; URIC-ACID; DIETARY FRUCTOSE;
   HEPATOCELLULAR-CARCINOMA; LIPID-ACCUMULATION; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; NONALCOHOLIC STEATOHEPATITIS
AB Chronic diseases represent a major challenge in world health. Metabolic syndrome is a constellation of disturbances affecting several organs, and it has been proposed to be a liver-centered condition. Fructose overconsumption may result in insulin resistance, oxidative stress, inflammation, elevated uric acid levels, increased blood pressure, and increased triglyceride concentrations in both the blood and liver. Non-alcoholic fatty liver disease (NAFLD) is a term widely used to describe excessive fatty infiltration in the liver in the absence of alcohol, autoimmune disorders, or viral hepatitis; it is attributed to obesity, high sugar and fat consumption, and sedentarism. If untreated, NAFLD can progress to nonalcoholic steatohepatitis (NASH), characterized by inflammation and mild fibrosis in addition to fat infiltration and, eventually, advanced scar tissue deposition, cirrhosis, and finally liver cancer, which constitutes the culmination of the disease. Notably, fructose is recognized as a major mediator of NAFLD, as a significant correlation between fructose intake and the degree of inflammation and fibrosis has been found in preclinical and clinical studies. Moreover, fructose is a risk factor for liver cancer development. Interestingly, fructose induces a number of proinflammatory, fibrogenic, and oncogenic signaling pathways that explain its deleterious effects in the body, especially in the liver.
C1 [Muriel, Pablo] Cinvestav IPN, Dept Pharmacol, Lab Expt Hepatol, Apartado Postal 14-740, Mexico City 07300, DF, Mexico.
   [Lopez-Sanchez, Pedro; Ramos-Tovar, Erika] Sch Higher Educ Med IPN, Postgrad Studies & Res Sect, Plan San Luis Diaz Miron S-N Casco Santo Tomas, Mexico City 11340, Mexico.
C3 CINVESTAV - Centro de Investigacion y de Estudios Avanzados del
   Instituto Politecnico Nacional
RP Ramos-Tovar, E (corresponding author), Sch Higher Educ Med IPN, Postgrad Studies & Res Sect, Plan San Luis Diaz Miron S-N Casco Santo Tomas, Mexico City 11340, Mexico.
EM pmuriel@cinvestav.mx; pelosa651018@yahoo.com; erikaramost@gmail.com
RI Ramos-Tovar, Erika/HRB-9713-2023; Muriel, Pablo/H-5156-2017; Lopez,
   Pedro/A-1283-2008
OI Muriel, Pablo/0000-0002-2236-6631; Lopez, Pedro/0000-0002-8089-9794;
   Ramos-Tovar, Erika/0000-0002-6616-9760
FU Consejo Nacional de Ciencia y Tecnologia through the Ciencia de Frontera
   funding program [53358]
FX This work was financially supported by Consejo Nacional de Ciencia y
   Tecnologia through the Ciencia de Frontera funding program, grant number
   53358.
CR Afonina IS, 2017, NAT IMMUNOL, V18, P861, DOI 10.1038/ni.3772
   Afzali A, 2010, HEPATOLOGY, V52, P578, DOI 10.1002/hep.23717
   Al-Jawadi A, 2020, J NUTR, V150, P1722, DOI 10.1093/jn/nxaa113
   Albano E, 2005, ALIMENT PHARM THER, V22, P71, DOI 10.1111/j.1365-2036.2005.02601.x
   Aldaba-Muruato LR, 2012, BBA-GEN SUBJECTS, V1820, P65, DOI 10.1016/j.bbagen.2011.09.018
   Ali ES, 2019, TRENDS ENDOCRIN MET, V30, P270, DOI 10.1016/j.tem.2019.02.005
   Andres-Hernando A, 2020, CELL METAB, V32, P117, DOI 10.1016/j.cmet.2020.05.012
   Andres-Hernando A, 2019, CURR OPIN CLIN NUTR, V22, P289, DOI 10.1097/MCO.0000000000000573
   [Anonymous], 2015, Guideline: sugars intake for adults and children
   Anstee QM, 2013, NAT REV GASTRO HEPAT, V10, P330, DOI 10.1038/nrgastro.2013.41
   Arauz J, 2016, ANN HEPATOL, V15, P160, DOI 10.5604/16652681.1193701
   Arroyave-Ospina JC, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10020174
   Artlett Carol M, 2012, Open Rheumatol J, V6, P80, DOI 10.2174/1874312901206010080
   Ballestri S, 2016, HEPATOL RES, V46, P1074, DOI 10.1111/hepr.12656
   Barnes PJ, 1997, NEW ENGL J MED, V336, P1066, DOI 10.1056/NEJM199704103361506
   Barone S, 2009, J BIOL CHEM, V284, P5056, DOI 10.1074/jbc.M808128200
   Basto-Abreu A, 2018, PLOS MED, V15, DOI 10.1371/journal.pmed.1002664
   Bates J, 2020, J HEPATOL, V73, P896, DOI 10.1016/j.jhep.2020.04.037
   Bellentani S, 2017, LIVER INT, V37, P81, DOI 10.1111/liv.13299
   Bellezza I, 2018, BBA-MOL CELL RES, V1865, P721, DOI 10.1016/j.bbamcr.2018.02.010
   Bergheim I, 2008, J HEPATOL, V48, P983, DOI 10.1016/j.jhep.2008.01.035
   Berthoud HR, 2020, PHYSIOL BEHAV, V222, DOI 10.1016/j.physbeh.2020.112959
   Bjornstad P, 2015, DIABETOLOGIA, V58, P1993, DOI 10.1007/s00125-015-3650-4
   Bodnaruc AM, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0153-3
   Boeckmans J, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9010037
   Braga TT, 2017, SCI REP-UK, V7, DOI 10.1038/srep39884
   Brennan P, 2020, WORLD J GASTROENTERO, V26, P1683, DOI 10.3748/wjg.v26.i15.1683
   Bu PC, 2018, CELL METAB, V27, P1249, DOI 10.1016/j.cmet.2018.04.003
   Caliceti C, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040395
   Calvente CJ, 2020, MOL THER, V28, P653, DOI 10.1016/j.ymthe.2019.09.013
   Chartoumpekis DV, 2018, JCI INSIGHT, V3, DOI 10.1172/jci.insight.97735
   Chen L, 2019, FRONT ONCOL, V9, DOI 10.3389/fonc.2019.01412
   Cho YE, 2021, HEPATOLOGY, V73, P2180, DOI 10.1002/hep.30652
   Cioffi F, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040323
   Dai BH, 2013, CELL DEATH DIS, V4, DOI 10.1038/cddis.2013.134
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   Diggle CP, 2009, J HISTOCHEM CYTOCHEM, V57, P763, DOI 10.1369/jhc.2009.953190
   Do MH, 2018, NUTRIENTS, V10, DOI 10.3390/nu10060761
   Dong XL, 2014, ALCOHOL CLIN EXP RES, V38, P68, DOI 10.1111/acer.12209
   Eckel RH, 2010, LANCET, V375, P181, DOI 10.1016/S0140-6736(09)61794-3
   Engstler AJ, 2016, GUT, V65, P1564, DOI 10.1136/gutjnl-2014-308379
   Farrell GC, 2012, AM J PHYSIOL-GASTR L, V303, pG9, DOI 10.1152/ajpgi.00008.2012
   Feng XJ, 2020, PROG LIPID RES, V77, DOI 10.1016/j.plipres.2019.101006
   Ferraris RP, 2018, ANNU REV NUTR, V38, P41, DOI 10.1146/annurev-nutr-082117-051707
   Figueroa-Romero C, 2008, REV ENDOCR METAB DIS, V9, P301, DOI 10.1007/s11154-008-9104-2
   Fisher FM, 2017, MOL METAB, V6, P14, DOI 10.1016/j.molmet.2016.11.008
   Francey C, 2019, CLIN NUTR ESPEN, V29, P125, DOI 10.1016/j.clnesp.2018.11.008
   Francque S, 2015, J HEPATOL, V63, P164, DOI 10.1016/j.jhep.2015.02.019
   Glendinning JI, 2017, AM J PHYSIOL-REG I, V312, pR597, DOI 10.1152/ajpregu.00433.2016
   Goedeke L, 2018, HEPATOLOGY, V68, P2197, DOI 10.1002/hep.30097
   Gonzalez-Vicente A, 2019, AM J PHYSIOL-RENAL, V316, pF473, DOI 10.1152/ajprenal.00247.2018
   Hannou SA, 2018, J CLIN INVEST, V128, P545, DOI 10.1172/JCI96702
   Hanousková B, 2019, J NUTR BIOCHEM, V68, P42, DOI 10.1016/j.jnutbio.2019.03.001
   Hayashi M, 2021, NUTR CANCER, V73, P996, DOI 10.1080/01635581.2020.1779758
   Healy ME, 2016, SCI REP-UK, V6, DOI 10.1038/srep22292
   Healy ME, 2015, J HEPATOL, V62, P599, DOI 10.1016/j.jhep.2014.10.024
   Herman MA, 2016, TRENDS ENDOCRIN MET, V27, P719, DOI 10.1016/j.tem.2016.06.005
   Hieronimus B, 2020, CURR OPIN LIPIDOL, V31, P20, DOI 10.1097/MOL.0000000000000653
   Hieronimus B, 2019, J CLIN MED, V8, DOI 10.3390/jcm8070913
   Hussain SP, 2003, NAT REV CANCER, V3, P276, DOI 10.1038/nrc1046
   Ichigo Y, 2019, PHYSIOL RES, V68, P1021, DOI 10.33549/physiolres.934226
   Ignat SR, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9020461
   Ishihara Y, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20112652
   Jaeschke H, 2011, J GASTROEN HEPATOL, V26, P173, DOI 10.1111/j.1440-1746.2010.06592.x
   Jaganjac M, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9111151
   Jaiswal N, 2015, APOPTOSIS, V20, P930, DOI 10.1007/s10495-015-1128-y
   Jang C, 2020, NAT METAB, V2, P586, DOI 10.1038/s42255-020-0222-9
   Jang C, 2018, CELL METAB, V27, P351, DOI 10.1016/j.cmet.2017.12.016
   Jegatheesan P, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030230
   Jensen T, 2018, J HEPATOL, V68, P1063, DOI 10.1016/j.jhep.2018.01.019
   Jhang JJ, 2015, CELL MOL IMMUNOL, V12, P424, DOI 10.1038/cmi.2014.65
   Jiang Joy X, 2014, Adv Hepatol, V2014
   Johnson RK, 2009, CIRCULATION, V120, P1011, DOI 10.1161/CIRCULATIONAHA.109.192627
   Jones HF, 2011, AM J PHYSIOL-GASTR L, V300, pG202, DOI 10.1152/ajpgi.00457.2010
   Kaneko C, 2017, BBA-GEN SUBJECTS, V1861, P559, DOI 10.1016/j.bbagen.2016.11.042
   Kanwal F, 2020, HEPATOLOGY, V71, P808, DOI 10.1002/hep.31014
   Kellett GL, 2008, ANNU REV NUTR, V28, P35, DOI 10.1146/annurev.nutr.28.061807.155518
   Kennedy L, 2021, HEPATOLOGY, V73, P2092, DOI 10.1002/hep.30843
   Khosla UM, 2005, KIDNEY INT, V67, P1739, DOI 10.1111/j.1523-1755.2005.00273.x
   Kim J, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-19263-1
   Kim M, 2017, JCI INSIGHT, V2, DOI 10.1172/jci.insight.96703
   Kim SK, 2019, BIOCHEM BIOPH RES CO, V511, P725, DOI 10.1016/j.bbrc.2019.02.141
   Kishida K, 2017, AM J PHYSIOL-GASTR L, V312, pG592, DOI 10.1152/ajpgi.00416.2016
   Kmietowicz Z, 2012, BMJ-BRIT MED J, V345, DOI 10.1136/bmj.e7994
   Koek GH, 2011, CLIN CHIM ACTA, V412, P1297, DOI 10.1016/j.cca.2011.04.013
   Koliaki Chrysi, 2010, Int J Pept, V2010, DOI 10.1155/2010/710852
   Kolodziejczyk AA, 2019, EMBO MOL MED, V11, DOI 10.15252/emmm.201809302
   Krause N, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9122635
   Kucera O, 2014, WORLD J GASTROENTERO, V20, P8364, DOI 10.3748/wjg.v20.i26.8364
   Lambertz J, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01159
   Lanaspa MA, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3434
   Lee HJ, 2018, BMB REP, V51, P429, DOI 10.5483/BMBRep.2018.51.9.197
   Lee O, 2009, CHEM-BIOL INTERACT, V178, P332, DOI 10.1016/j.cbi.2008.10.011
   Li LC, 2013, AM J PHYSIOL-HEART C, V304, pH874, DOI 10.1152/ajpheart.00096.2012
   Lian CY, 2020, CHEM-BIOL INTERACT, V330, DOI 10.1016/j.cbi.2020.109199
   Liang JQ, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-06931-6
   Lim JS, 2010, NAT REV GASTRO HEPAT, V7, P251, DOI 10.1038/nrgastro.2010.41
   Lin HY, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9041041
   Lin S, 2020, LIVER INT, V40, P2082, DOI 10.1111/liv.14548
   Lonardo A, 2015, DIGEST LIVER DIS, V47, P181, DOI 10.1016/j.dld.2014.09.020
   Lowette Katrien, 2015, Front Nutr, V2, P5, DOI 10.3389/fnut.2015.00005
   Lu SC, 2009, MOL ASPECTS MED, V30, P42, DOI 10.1016/j.mam.2008.05.005
   Lustig RH, 2010, J AM DIET ASSOC, V110, P1307, DOI 10.1016/j.jada.2010.06.008
   Marengo A, 2016, ANNU REV MED, V67, P103, DOI 10.1146/annurev-med-090514-013832
   Margini C, 2016, LIVER INT, V36, P317, DOI 10.1111/liv.13031
   Mastrocola R, 2018, J NUTR BIOCHEM, V55, P185, DOI 10.1016/j.jnutbio.2018.02.003
   Matsumoto M, 2018, FREE RADICAL BIO MED, V115, P412, DOI 10.1016/j.freeradbiomed.2017.12.019
   Mazzoli A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112670
   Mellouk Z, 2012, MOL MED REP, V6, P1399, DOI 10.3892/mmr.2012.1091
   Merino B, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010094
   MILLER WC, 1994, J AM DIET ASSOC, V94, P612, DOI 10.1016/0002-8223(94)90155-4
   Milutinovic DV, 2020, MOL NUTR FOOD RES, V64, DOI 10.1002/mnfr.201901141
   Moine L, 2018, WORLD J GASTROENTERO, V24, P4979, DOI 10.3748/wjg.v24.i44.4979
   Montgomery MK, 2015, ENDOCR CONNECT, V4, DOI 10.1530/EC-14-0092
   Muhidin SO, 2012, J OBES, V2012, DOI 10.1155/2012/637538
   Nagaoki Y, 2012, HEPATOL RES, V42, P368, DOI 10.1111/j.1872-034X.2011.00929.x
   Nakagawa T, 2006, AM J PHYSIOL-RENAL, V290, pF625, DOI 10.1152/ajprenal.00140.2005
   Nakagawa T, 2020, CANCER METAB, V8, DOI 10.1186/s40170-020-00222-9
   Ndrepepa G, 2018, CLIN CHIM ACTA, V484, P150, DOI 10.1016/j.cca.2018.05.046
   Nergiz-Unal R, 2020, NUTRITION, V79-80, DOI 10.1016/j.nut.2020.110954
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Nigro D, 2017, J NUTR BIOCHEM, V42, P160, DOI 10.1016/j.jnutbio.2017.01.010
   Noblet B, 2021, ISCIENCE, V24, DOI 10.1016/j.isci.2021.102218
   Novelle MG, 2021, ISCIENCE, V24, DOI 10.1016/j.isci.2021.102071
   Ochoa M, 2015, EUR J NUTR, V54, P1, DOI 10.1007/s00394-014-0776-y
   Ohashi K, 2015, BIOCHEM BIOPH RES CO, V468, P185, DOI 10.1016/j.bbrc.2015.10.134
   Oral A, 2019, MEDICINA-LITHUANIA, V55, DOI 10.3390/medicina55090600
   Pan J.H., 2019, CURR DEV NUTR, V3, DOI [10.1093/cdn/nzz037.P15-011-19, DOI 10.1093/CDN/NZZ037.P15-011-19]
   Pan JH, 2021, FOOD FUNCT, V12, P656, DOI [10.1039/d0fo02286a, 10.1039/D0FO02286A]
   Pan JH, 2019, BRIT J NUTR, V122, P769, DOI 10.1017/S0007114519001612
   Paschos P, 2018, CURR VASC PHARMACOL, V16, P269, DOI 10.2174/1570161115666170621082237
   Patel C, 2015, AM J PHYSIOL-REG I, V309, pR499, DOI 10.1152/ajpregu.00128.2015
   Pereira RM, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040405
   Powell ES, 2016, J ACAD NUTR DIET, V116, P1543, DOI 10.1016/j.jand.2016.06.003
   Rahman K, 2016, GASTROENTEROLOGY, V151, P733, DOI 10.1053/j.gastro.2016.06.022
   Rahman R, 2013, WORLD J GASTRO ONCOL, V5, P186, DOI 10.4251/wjgo.v5.i9.186
   Ramos-Tovar E, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9121279
   Ramos-Tovar E, 2020, J APPL TOXICOL, V40, P151, DOI 10.1002/jat.3880
   Rebollo A, 2014, BBA-MOL CELL BIOL L, V1841, P514, DOI 10.1016/j.bbalip.2014.01.002
   Roomi Mudassar Ali, 2019, J Ayub Med Coll Abbottabad, V31, P252
   Rosas-Villegas A, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040393
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sanchez-Lozada LG, 2019, J BIOL CHEM, V294, P4272, DOI 10.1074/jbc.RA118.006158
   Santhekadur PK, 2020, GENES DIS, V7, P163, DOI 10.1016/j.gendis.2019.10.001
   Sanyal AJ, 2001, GASTROENTEROLOGY, V120, P1183, DOI 10.1053/gast.2001.23256
   Seki Kenichiro, 2018, Oncotarget, V9, P28638, DOI 10.18632/oncotarget.25587
   Sekiya M, 2008, BIOCHEM BIOPH RES CO, V375, P602, DOI 10.1016/j.bbrc.2008.08.068
   Sergi D, 2021, MOL NUTR FOOD RES, V65, DOI 10.1002/mnfr.201900934
   Shah A, 2020, ISCIENCE, V23, DOI 10.1016/j.isci.2020.101521
   Shepherd EL, 2021, JHEP REP, V3, DOI 10.1016/j.jhepr.2020.100217
   Shi JH, 2020, DIABETES, V69, P591, DOI 10.2337/db19-0388
   Simeonova D, 2018, CURR TOP MED CHEM, V18, P1641, DOI 10.2174/1568026618666181115100610
   Softic S, 2020, CRIT REV CL LAB SCI, V57, P308, DOI 10.1080/10408363.2019.1711360
   Softic S, 2019, CELL METAB, V30, P735, DOI 10.1016/j.cmet.2019.09.003
   Softic S, 2017, J CLIN INVEST, V127, P4059, DOI 10.1172/JCI94585
   Softic S, 2016, DIGEST DIS SCI, V61, P1282, DOI 10.1007/s10620-016-4054-0
   Song Byoung-Joon, 2015, Adv Pharmacol, V74, P303, DOI 10.1016/bs.apha.2015.04.002
   Spiga R, 2017, ARTERIOSCL THROM VAS, V37, P1241, DOI 10.1161/ATVBAHA.117.309128
   Spindel ON, 2012, ANTIOXID REDOX SIGN, V16, P587, DOI 10.1089/ars.2011.4137
   Stanhope KL, 2009, J CLIN INVEST, V119, P1322, DOI 10.1172/JCI37385
   Steenson S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061781
   Streba LAM, 2015, WORLD J GASTROENTERO, V21, P4103, DOI 10.3748/wjg.v21.i14.4103
   Takanashi M, 2019, ARTERIOSCL THROM VAS, V39, P373, DOI 10.1161/ATVBAHA.118.311931
   Tappy L, 2018, J EXP BIOL, V221, DOI 10.1242/jeb.164202
   Taskinen MR, 2019, NUTRIENTS, V11, DOI 10.3390/nu11091987
   Taylor PM, 2014, AM J CLIN NUTR, V99, p223S, DOI 10.3945/ajcn.113.070086
   Todoric J, 2020, NAT METAB, V2, P1034, DOI 10.1038/s42255-020-0261-2
   Vos MB, 2013, HEPATOLOGY, V57, P2525, DOI 10.1002/hep.26299
   Wagnerberger S, 2012, BRIT J NUTR, V107, P1727, DOI 10.1017/S0007114511004983
   Wan XY, 2016, J HEPATOL, V64, P925, DOI 10.1016/j.jhep.2015.11.022
   Wang M, 2020, HEPATOLOGY, V72, P1617, DOI 10.1002/hep.31197
   Welzel TM, 2011, HEPATOLOGY, V54, P463, DOI 10.1002/hep.24397
   Wong MCS, 2017, SCI REP-UK, V7, DOI 10.1038/srep45846
   Wong VWS, 2021, CLIN GASTROENTEROL H, V19, P2161, DOI 10.1016/j.cgh.2020.10.046
   Wree A, 2014, HEPATOLOGY, V59, P898, DOI 10.1002/hep.26592
   Wu XQ, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01728
   Xu DW, 2019, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01428
   Yamazaki M, 2020, J NUTR BIOCHEM, V82, DOI 10.1016/j.jnutbio.2020.108386
   Yang Y, 2016, GENET MOL RES, V15, DOI 10.4238/gmr.15028644
   Yau AMW, 2014, NUTRITION, V30, P1344, DOI 10.1016/j.nut.2014.03.023
   Yki-Järvinen H, 2014, LANCET DIABETES ENDO, V2, P901, DOI 10.1016/S2213-8587(14)70032-4
   Yun Y, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0190194
   Zarfeshani A, 2015, J CLIN MED, V4, P1938, DOI 10.3390/jcm4111938
   Zhang CW, 2020, BIOMED PHARMACOTHER, V131, DOI 10.1016/j.biopha.2020.110795
   Zhang DQ, 2021, HEPATOL COMMUN, V5, P992, DOI 10.1002/hep4.1683
   Zhang X, 2015, ANTIOXID REDOX SIGN, V22, P848, DOI 10.1089/ars.2014.5868
   Zhao S, 2020, NATURE, V579, P586, DOI 10.1038/s41586-020-2101-7
   Zhao XJ, 2018, REDOX BIOL, V18, P124, DOI 10.1016/j.redox.2018.07.002
   Zhou RB, 2010, NAT IMMUNOL, V11, P136, DOI 10.1038/ni.1831
   Zhou Y, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039738
   Zhu LX, 2013, HEPATOLOGY, V57, P601, DOI 10.1002/hep.26093
   Zwarts I, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-45803-x
NR 192
TC 86
Z9 91
U1 7
U2 46
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL
PY 2021
VL 22
IS 13
AR 6969
DI 10.3390/ijms22136969
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA TF8YA
UT WOS:000671000100001
PM 34203484
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mali, VR
   Ning, RZ
   Chen, JL
   Yang, XP
   Xu, J
   Palaniyandi, SS
AF Mali, Vishal R.
   Ning, Ruizhuo
   Chen, Jieli
   Yang, Xiao-Ping
   Xu, Jiang
   Palaniyandi, Suresh S.
TI Impairment of aldehyde dehydrogenase-2 by 4-hydroxy-2-nonenal adduct
   formation and cardiomyocyte hypertrophy in mice fed a high-fat diet and
   injected with low-dose streptozotocin
SO EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Article
DE metabolic syndrome; type-2 diabetes mellitus; 4-hydroxy-2-nonenal;
   diabetic cardiac complications; Aldehyde dehydrogenase 2; cardiomyocyte
   hypertrophy
ID ADVANCED GLYCATION; OXIDATIVE STRESS; LIPID-PEROXIDATION;
   MYOCARDIAL-INFARCTION; CONTRACTILE FUNCTION; ALDH2; INHIBITION; RAT;
   DYSFUNCTION; MODEL
AB Reactive aldehydes such as 4-hydroxy-2-nonenal (4HNE) are generated in the myocardium in cardiac disease. 4HNE and other toxic aldehydes form adducts with proteins, leading to cell damage and organ dysfunction. Aldehyde dehydrogenases (ALDHs) metabolize toxic aldehydes such as 4HNE into nontoxic metabolites. Both ALDH levels and activity are reduced in cardiac disease. We examined whether reduced ALDH2 activity contributes to cardiomyocyte hypertrophy in mice fed a high-fat diet and injected with low-dose streptozotocin (STZ). These mice exhibited most of the characteristics of metabolic syndrome/type-2 diabetes mellitus (DM): increased blood glucose levels depicting hyperglycemia (415.2 +/- 18.7 mg/dL vs. 265.2 +/- 7.6 mg/dL; P < 0.05), glucose intolerance with normal plasma insulin levels, suggesting insulin resistance and obesity as evident from increased weight (44 +/- 3.1 vs. 34.50 +/- 1.32 g; P < 0.05) and body fat. Myocardial ALDH2 activity was 60% lower in these mice (0.1 +/- 0.012 vs. 0.04 +/- 0.015 mu mol/min/mg protein; P < 0.05). Myocardial 4HNE levels were also elevated in the hyperglycemic hearts. Co-immunoprecipitation study showed that 4HNE formed adducts on myocardial ALDH2 protein in the mice exhibiting metabolic syndrome/type-2 DM, and they had obvious cardiac hypertrophy compared with controls as evident from increased heart weight (HW), HW to tibial length ratio, left ventricular (LV) mass and cardiomyocyte hypertrophy. Cardiomyocyte hypertrophy was correlated inversely with ALDH2 activity (R-2 = 0.7; P < 0.05). Finally, cardiac dysfunction was observed in mice with metabolic syndrome/type-2 DM. Therefore, we conclude that reduced ALDH2 activity may contribute to cardiac hypertrophy and dysfunction in mice presenting with some of the characteristics of metabolic syndrome/type-2 DM when on a high-fat diet and low-dose STZ injection.
C1 [Mali, Vishal R.; Yang, Xiao-Ping; Xu, Jiang; Palaniyandi, Suresh S.] Henry Ford Hlth Syst, Dept Internal Med, Div Hypertens & Vasc Res, Detroit, MI 48202 USA.
   [Ning, Ruizhuo; Chen, Jieli] Henry Ford Hlth Syst, Dept Neurol, Detroit, MI 48202 USA.
   [Palaniyandi, Suresh S.] Wayne State Univ, Dept Physiol, Detroit, MI 48202 USA.
C3 Henry Ford Health System; Henry Ford Hospital; Henry Ford Health System;
   Henry Ford Hospital; Wayne State University
RP Palaniyandi, SS (corresponding author), Henry Ford Hlth Syst, Dept Internal Med, Div Hypertens & Vasc Res, Detroit, MI 48202 USA.
EM spalani2@hfhs.org
RI ning, ruizhuo/E-6401-2012
FU National Institute on Aging [AG031811, 1R41NS080329]; Henry Ford Health
   System
FX The authors thank Prof. William Beierwaltes for his critical comments.
   This work was supported by the National Institute on Aging Grants
   AG031811 (J.C.), 1R41NS080329 (J.C.), and an internal grant from Henry
   Ford Health System (S.S.P.).
CR Amamoto K, 2002, HYPERTENS RES, V25, P857
   Arulmozhi DK, 2008, J PHARM PHARMACOL, V60, P1167, DOI 10.1211/jpp.60.9.0008
   Bardag-Gorce F, 2005, EXP MOL PATHOL, V78, P109, DOI 10.1016/j.yexmp.2004.10.005
   Calabrese V, 2007, CELL STRESS CHAPERON, V12, P299, DOI 10.1379/CSC-270.1
   Camp TM, 2003, DIABETOLOGIA, V46, P1438, DOI 10.1007/s00125-003-1200-y
   Cantero AV, 2007, FASEB J, V21, P3096, DOI 10.1096/fj.06-7536com
   Chang YC, 2012, BMC CARDIOVASC DISOR, V12, DOI 10.1186/1471-2261-12-58
   Chen CH, 2008, SCIENCE, V321, P1493, DOI 10.1126/science.1158554
   Cohn JA, 1996, ARCH BIOCHEM BIOPHYS, V328, P158, DOI 10.1006/abbi.1996.0156
   Eaton P, 1999, AM J PHYSIOL-HEART C, V276, pH935, DOI 10.1152/ajpheart.1999.276.3.H935
   ESTERBAUER H, 1991, FREE RADICAL BIO MED, V11, P81, DOI 10.1016/0891-5849(91)90192-6
   Feng BA, 2008, AM J PHYSIOL-ENDOC M, V294, pE1119, DOI 10.1152/ajpendo.00029.2008
   Ferrington DA, 2004, FEBS LETT, V578, P217, DOI 10.1016/j.febslet.2004.11.003
   Forbes SP, 2008, BIOCHEMISTRY-US, V47, P1819, DOI 10.1021/bi701659n
   Furfaro AL, 2005, BIOFACTORS, V24, P291, DOI 10.1002/biof.5520240134
   Hamblin M, 2007, J MOL CELL CARDIOL, V42, P884, DOI 10.1016/j.yjmcc.2006.12.018
   Hintz KK, 2003, ALCOHOL CLIN EXP RES, V27, P1090, DOI 10.1097/01.ALC.0000075823.73536.DD
   Horie K, 1997, J CLIN INVEST, V100, P2995, DOI 10.1172/JCI119853
   Hsueh W, 2007, CIRC RES, V100, P1415, DOI 10.1161/01.RES.0000266449.37396.1f
   Isom AL, 2004, J AM SOC MASS SPECTR, V15, P1136, DOI 10.1016/j.jasms.2004.03.013
   Jo SA, 2007, CLIN CHIM ACTA, V382, P43, DOI 10.1016/j.cca.2007.03.016
   Lagranha CJ, 2010, CIRC RES, V106, P1681, DOI 10.1161/CIRCRESAHA.109.213645
   Lashin OM, 2006, FREE RADICAL BIO MED, V40, P886, DOI 10.1016/j.freeradbiomed.2005.10.040
   Li SY, 2009, J MOL CELL CARDIOL, V47, P247, DOI 10.1016/j.yjmcc.2009.03.017
   Lucas DT, 1998, P NATL ACAD SCI USA, V95, P510, DOI 10.1073/pnas.95.2.510
   Ma H, 2011, EUR HEART J, V32, P1025, DOI 10.1093/eurheartj/ehq253
   Ma H, 2009, J AM COLL CARDIOL, V54, P2187, DOI 10.1016/j.jacc.2009.04.100
   Murata C, 2004, DIABETES RES CLIN PR, V66, pS145, DOI 10.1016/j.diabres.2003.11.022
   Murata CT, 2003, METABOLISM, V52, P1096, DOI 10.1016/S0026-0495(03)00183-5
   Nakamura K, 2009, J CARD FAIL, V15, P709, DOI 10.1016/j.cardfail.2009.04.008
   Palaniyandi SS, 2007, EXP BIOL MED, V232, P1213, DOI 10.3181/0703-RM-85
   Palaniyandi SS, 2010, FASEB J, V24
   Panchal SK, 2011, J BIOMED BIOTECHNOL, DOI 10.1155/2011/351982
   Reed MJ, 2000, METABOLISM, V49, P1390, DOI 10.1053/meta.2000.17721
   Roede JR, 2010, ENVIRON MOL MUTAGEN, V51, P380, DOI 10.1002/em.20553
   Salem KA, 2009, PHARMACOL RES, V59, P235, DOI 10.1016/j.phrs.2009.01.003
   Selvakumar D, 2012, BIOCHEM J, V443, P463, DOI 10.1042/BJ20111255
   Singh R, 2001, DIABETOLOGIA, V44, P129, DOI 10.1007/s001250051591
   Sourris KC, 2009, AM J NEPHROL, V30, P323, DOI 10.1159/000226586
   Srinivasan K, 2005, PHARMACOL RES, V52, P313, DOI 10.1016/j.phrs.2005.05.004
   SURWIT RS, 1988, DIABETES, V37, P1163, DOI 10.2337/diabetes.37.9.1163
   Suzuki Y, 2004, ALCOHOL CLIN EXP RES, V28, p111S, DOI 10.1097/01.ALC.0000133583.44581.99
   Takagi S, 2002, HYPERTENS RES, V25, P677
   Traverso N, 2002, FREE RADICAL BIO MED, V32, P350, DOI 10.1016/S0891-5849(01)00811-5
   Uchida K, 2000, FREE RADICAL BIO MED, V28, P1685, DOI 10.1016/S0891-5849(00)00226-4
   Vasiliou V, 2000, CHEM-BIOL INTERACT, V129, P1, DOI 10.1016/S0009-2797(00)00211-8
   Wang JL, 2011, MOL MED, V17, P172, DOI 10.2119/molmed.2010.00114
   Winzell MS, 2004, DIABETES, V53, pS215, DOI 10.2337/diabetes.53.suppl_3.S215
   Wold LE, 2004, BIOCHEM BIOPH RES CO, V318, P1066, DOI 10.1016/j.bbrc.2004.04.138
   Xiao J, 2010, BIOL PHARM BULL, V33, P444, DOI 10.1248/bpb.33.444
   Yamagishi S, 2009, PHARMACOL RES, V60, P174, DOI 10.1016/j.phrs.2009.01.006
   Yang XP, 1999, AM J PHYSIOL-HEART C, V277, pH1967, DOI 10.1152/ajpheart.1999.277.5.H1967
   Ye G, 2004, DIABETES, V53, P1336, DOI 10.2337/diabetes.53.5.1336
   Zhang M, 2008, EXP DIABETES RES, DOI 10.1155/2008/704045
   Zhang YM, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-40
   Zhang YM, 2011, PHARMACOL THERAPEUT, V132, P86, DOI 10.1016/j.pharmthera.2011.05.008
   Zhang YM, 2010, AUTOPHAGY, V6, P1212, DOI 10.4161/auto.6.8.13652
NR 57
TC 51
Z9 53
U1 0
U2 16
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1535-3702
EI 1535-3699
J9 EXP BIOL MED
JI Exp. Biol. Med.
PD MAY
PY 2014
VL 239
IS 5
BP 610
EP 618
DI 10.1177/1535370213520109
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AG6EM
UT WOS:000335511500011
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Rodríguez-Pérez, C
   García-Villanova, B
   Guerra-Hernández, E
   Verardo, V
AF Rodriguez-Perez, Celia
   Garcia-Villanova, Belen
   Guerra-Hernandez, Eduardo
   Verardo, Vito
TI Grape Seeds Proanthocyanidins: An Overview of In Vivo Bioactivity in
   Animal Models
SO NUTRIENTS
LA English
DT Review
DE grape seed by-products; proanthocyanidins; metabolic syndrome; chronic
   diseases; in vivo animal studies
ID OXIDATIVE STRESS; PHENOLIC-COMPOUNDS; PROCYANIDINS; EXTRACT;
   INFLAMMATION; ANTIOXIDANT; ANTHOCYANINS; BIOSYNTHESIS; ACCUMULATION;
   HYPERTENSION
AB Over the last decade, proanthocyanidins (PACs) are attracting attention not only from the food industry but also from public health organizations due to their health benefits. It is well-known that grapes are a good source of PACs and for that reason, the industry is also focused on grape by-products identification and bioactivity evaluation. Grape seeds extract (GSPE) is a rich source of PACs, mainly composed of monomeric catechin and epicatechin, gallic acid and polymeric and oligomeric proanthocyanidins. Thus, this review encompasses the state-of-art structure and the most recent evidence about the impact of GSPE on chronic diseases, with a focus on oxidative stress, inflammation and metabolic syndrome (MeS)-related disorders such as obesity, diabetes and cardiovascular risk disease in vivo to offer new perspectives in the field that allow further research. Despite the controversial results, is undeniable that PACs from grape seeds are highly antioxidants, thus, the capacity of GSPE to improve oxidative stress might mediate the inflammation process and the progress of MeS-related pathologies. However, further well-design animal studies with standardized dosages and GSPE composition are necessary to shed light into the cause-effect relationship in a more accurate way to later allow a deeper study of the effect of GSPE in humans.
C1 [Rodriguez-Perez, Celia; Garcia-Villanova, Belen; Guerra-Hernandez, Eduardo; Verardo, Vito] Univ Granada, Dept Nutr & Food Sci, Campus Cartuja, E-18071 Granada, Spain.
   [Rodriguez-Perez, Celia; Verardo, Vito] Univ Granada, Biomed Res Ctr, Inst Nutr & Food Technol INYTA Jose Mataix, Ave Conocimiento S-N, E-18071 Granada, Spain.
C3 University of Granada; University of Granada
RP Verardo, V (corresponding author), Univ Granada, Dept Nutr & Food Sci, Campus Cartuja, E-18071 Granada, Spain.; Verardo, V (corresponding author), Univ Granada, Biomed Res Ctr, Inst Nutr & Food Technol INYTA Jose Mataix, Ave Conocimiento S-N, E-18071 Granada, Spain.
EM celiarp@ugr.es; belenv@ugr.es; ejguerra@ugr.es; vitoverardo@ugr.es
RI Rodríguez-Pérez, Celia/R-7378-2019; Guerra-Hernandez,
   Eduardo/K-9562-2014; verardo, vito/W-2878-2017
OI Guerra-Hernandez, Eduardo/0000-0002-2841-7743; Garcia-Villanova Ruiz,
   Belen/0000-0001-5114-300X; Rodriguez-Perez, Celia/0000-0002-7233-6481;
   verardo, vito/0000-0003-0723-5163
FU Spanish Ministry of Economy and Competitiveness (MINECO)
   [RYC-2015-18795]
FX Vito Verardo thanks the Spanish Ministry of Economy and Competitiveness
   (MINECO) for "Ramon y Cajal" contract (RYC-2015-18795).
CR Bagchi D, 2000, TOXICOLOGY, V148, P187, DOI 10.1016/S0300-483X(00)00210-9
   Bagchi D, 2014, MUTAT RES-FUND MOL M, V768, P69, DOI 10.1016/j.mrfmmm.2014.04.004
   Barba FJ, 2015, FOOD BIOPROCESS TECH, V8, P1139, DOI 10.1007/s11947-015-1482-3
   Bashir N, 2019, BIOSCIENCE REP, V39, DOI 10.1042/BSR20180515
   Bombai G, 2017, J SCI FOOD AGR, V97, P3058, DOI 10.1002/jsfa.8151
   Bordiga M, 2019, INT J FOOD SCI TECH, V54, P933, DOI 10.1111/ijfs.14118
   Caimari A, 2013, INT J OBESITY, V37, P576, DOI 10.1038/ijo.2012.75
   Cassano A, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19020351
   Cedó L, 2013, FOOD CHEM, V138, P524, DOI 10.1016/j.foodchem.2012.10.088
   Chen FZ, 2019, J NUTR BIOCHEM, V67, P72, DOI 10.1016/j.jnutbio.2019.01.013
   Chen MS, 2017, J AGR FOOD CHEM, V65, P1598, DOI 10.1021/acs.jafc.6b05609
   Chen SZ, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0126457
   de Freitas VAP, 1998, PHYTOCHEMISTRY, V49, P1435, DOI 10.1016/S0031-9422(98)00107-1
   Di Mauro MD, 2017, EUR FOOD RES TECHNOL, V243, P1895, DOI 10.1007/s00217-017-2893-3
   Ding Y, 2013, NUTR METAB, V10, DOI 10.1186/1743-7075-10-51
   ESCRIBANOBAILON T, 1992, J AGR FOOD CHEM, V40, P1794, DOI 10.1021/jf00022a013
   Favaretto F, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0109540
   Fernández-Iglesias A, 2014, MOL NUTR FOOD RES, V58, P727, DOI 10.1002/mnfr.201300455
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Fuleki T, 1997, J AGR FOOD CHEM, V45, P1156, DOI 10.1021/jf960493k
   Genebra T, 2014, INT J MOL SCI, V15, P11862, DOI 10.3390/ijms150711862
   Ginés I, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201800912
   Ginés I, 2018, NUTRIENTS, V10, DOI 10.3390/nu10030315
   González-Quilen C, 2019, NUTRIENTS, V11, DOI 10.3390/nu11050979
   Gracia KC, 2017, J CLIN MED, V6, DOI 10.3390/jcm6020022
   Gu LW, 2004, J NUTR, V134, P613, DOI 10.1093/jn/134.3.613
   He F, 2008, MOLECULES, V13, P2674, DOI 10.3390/molecules13102674
   Huang LL, 2015, J NUTR BIOCHEM, V26, P841, DOI 10.1016/j.jnutbio.2015.03.007
   Johnson MH, 2013, MOL NUTR FOOD RES, V57, P1182, DOI 10.1002/mnfr.201200678
   Salvadó MJ, 2015, FOOD FUNCT, V6, P1053, DOI 10.1039/c4fo01035c
   Kanoski SE, 2016, AM J PHYSIOL-REG I, V310, pR885, DOI 10.1152/ajpregu.00520.2015
   Kawakami K, 2011, BIOSCI BIOTECH BIOCH, V75, P1435, DOI 10.1271/bbb.100926
   Kuhnert S, 2015, J FUNCT FOODS, V15, P225, DOI 10.1016/j.jff.2015.03.031
   Li SG, 2015, BIOMED ENVIRON SCI, V28, P272, DOI 10.3967/bes2015.038
   Li WG, 2001, ACTA PHARMACOL SIN, V22, P1117
   Liu W, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201601082
   Liu XC, 2018, FOOD NUTR RES, V62, DOI 10.29219/fnr.v62.1421
   Lu JJ, 2018, FOOD CHEM TOXICOL, V116, P59, DOI 10.1016/j.fct.2018.03.034
   Lucarini M, 2018, MOLECULES, V23, DOI 10.3390/molecules23081888
   Ma ZF, 2017, ANTIOXIDANTS-BASEL, V6, DOI 10.3390/antiox6030071
   Machado NFL, 2017, MOLECULES, V22, DOI 10.3390/molecules22020286
   Maki KC, 2018, J AM COLL NUTR, V37, P121, DOI 10.1080/07315724.2017.1370398
   Mancuso P, 2016, IMMUNOTARGETS THER, V5, P47, DOI 10.2147/ITT.S73223
   Margalef M, 2015, J AGR FOOD CHEM, V63, P9996, DOI 10.1021/acs.jafc.5b03856
   MIDDLETON E, 1992, BIOCHEM PHARMACOL, V43, P1167, DOI 10.1016/0006-2952(92)90489-6
   Montagut G, 2010, J NUTR BIOCHEM, V21, P961, DOI 10.1016/j.jnutbio.2009.08.001
   Montero L, 2013, ANAL BIOANAL CHEM, V405, P4627, DOI 10.1007/s00216-012-6567-5
   Nawaz H, 2006, SEP PURIF TECHNOL, V48, P176, DOI 10.1016/j.seppur.2005.07.006
   Nazima B, 2016, HUM EXP TOXICOL, V35, P428, DOI 10.1177/0960327115591376
   Neilson AP, 2016, ANNU REV FOOD SCI T, V7, P43, DOI 10.1146/annurev-food-022814-015604
   Nelson RH, 2013, PRIMARY CARE, V40, P195, DOI 10.1016/j.pop.2012.11.003
   Nie Y, 2019, ADV NUTR, V10, P464, DOI 10.1093/advances/nmy118
   Niu Q, 2018, J TOXICOL SCI, V43, P311, DOI 10.2131/jts.43.311
   Nunes MA, 2016, TRENDS FOOD SCI TECH, V57, P31, DOI 10.1016/j.tifs.2016.08.017
   Pascual-Serrano A, 2017, INT J OBESITY, V41, P1246, DOI 10.1038/ijo.2017.90
   Pascual-Serrano A, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19092632
   Pasini F, 2019, MOLECULES, V24, DOI 10.3390/molecules24040677
   Prior RL, 2001, J AGR FOOD CHEM, V49, P1270, DOI 10.1021/jf001211q
   Prodanov M, 2013, J FOOD COMPOS ANAL, V31, P284, DOI 10.1016/j.jfca.2013.06.003
   Quiñones M, 2013, FOOD RES INT, V51, P587, DOI 10.1016/j.foodres.2013.01.023
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   Rauf A, 2019, BIOMED PHARMACOTHER, V116, DOI 10.1016/j.biopha.2019.108999
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Rodríguez-Pérez C, 2019, CRIT REV FOOD SCI, V59, P1212, DOI 10.1080/10408398.2017.1399859
   Rodríguez-Pérez C, 2016, FOOD FUNCT, V7, P1564, DOI [10.1039/C5FO01441G, 10.1039/c5fo01441g]
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Serrano J, 2017, EUR J NUTR, V56, P1629, DOI 10.1007/s00394-016-1209-x
   Serrano J, 2016, NUTRIENTS, V8, DOI 10.3390/nu8100652
   Silva V, 2018, FOOD CONTROL, V92, P516, DOI 10.1016/j.foodcont.2018.05.031
   Smeriglio A, 2017, BRIT J PHARMACOL, V174, P1244, DOI 10.1111/bph.13630
   Sundararajan A, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0201969
   Tang GY, 2018, MOLECULES, V23, DOI 10.3390/molecules23102598
   Terra X, 2011, J NUTR BIOCHEM, V22, P380, DOI 10.1016/j.jnutbio.2010.03.006
   Terra X, 2009, J NUTR BIOCHEM, V20, P210, DOI 10.1016/j.jnutbio.2008.02.005
   Thiruchenduran M, 2011, CARDIOVASC PATHOL, V20, P361, DOI 10.1016/j.carpath.2010.09.002
   Tomasello B, 2017, ONCOL LETT, V13, P441, DOI 10.3892/ol.2016.5449
   Travaglia F, 2011, J FOOD SCI, V76, pC742, DOI 10.1111/j.1750-3841.2011.02194.x
   Wang EH, 2019, RSC ADV, V9, P11842, DOI 10.1039/c9ra01017c
   Wang XH, 2013, PHYTOTHER RES, V27, P869, DOI 10.1002/ptr.4793
   Weseler AR, 2017, NUTR J, V16, DOI 10.1186/s12937-016-0218-1
   Winiarska-Mieczan A, 2018, BIOMETALS, V31, P909, DOI 10.1007/s10534-018-0153-z
   Yang L., 2018, BioMed Research International, P1, DOI DOI 10.1155/2018/8584136
   Yogalakshmi B, 2014, J CELL COMMUN SIGNAL, V8, P13, DOI 10.1007/s12079-013-0210-x
   Zhu F, 2019, CRIT REV FOOD SCI, V59, P1521, DOI 10.1080/10408398.2017.1418284
NR 84
TC 110
Z9 116
U1 13
U2 104
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2019
VL 11
IS 10
AR 2435
DI 10.3390/nu11102435
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA JP4HG
UT WOS:000498227300176
PM 31614852
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nusslock, R
   Miller, GE
AF Nusslock, Robin
   Miller, Gregory E.
TI Early-Life Adversity and Physical and Emotional Health Across the
   Lifespan: A Neuroimmune Network Hypothesis
SO BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Depression; Heart disease; Inflammation; Maltreatment; Poverty; Stress
ID CHILDHOOD SOCIOECONOMIC CIRCUMSTANCES; CAUSE-SPECIFIC MORTALITY; EARLY
   EXPERIENCE; CARDIOVASCULAR-DISEASE; INFLAMMATORY PROCESSES; DEPRESSIVE
   SYMPTOMS; INSULIN-RESISTANCE; METABOLIC SYNDROME; TELOMERE LENGTH;
   MATERNAL STRESS
AB Children who experience chronic stressors are vulnerable to emotional and physical health problems across the lifespan. This phenomenon raises questions for scientists and clinicians alike. How does adversity get under the skin of the developing child? Through what mechanisms does it confer vulnerability to a heterogeneous set of mental and physical illnesses? And how does it instantiate risk across different life stages, engendering vulnerability to conditions that develop shortly after stressor exposure-like depression-and conditions that manifest decades later, like heart disease? Although answers to these questions have started to emerge, research has typically focused on single diseases or organ systems. To understand the plethora of health problems associated with childhood adversity, we argue that the field needs a second generation of research that recognizes multidirectional transactions among biological systems. To help facilitate this process, we propose a neuroimmune network hypothesis as a heuristic framework for organizing knowledge from disparate literatures and as a springboard for generating integrative research. Drawing on existing data, we argue that early-life adversity amplifies crosstalk between peripheral inflammation and neural circuitries subserving threat-related, reward-related, and executive control-related processes. This crosstalk results in chronic low-grade inflammation, thereby contributing to adiposity, insulin resistance, and other predisease states. In the brain, inflammatory mediators act on cortico-amygdala threat and cortico-basal ganglia reward, circuitries in a manner that predisposes individuals to self-medicating behaviors like smoking, drug use, and consumption of high-fat diets. Acting in concert with inflammation, these behaviors accelerate the pathogenesis of emotional and physical health problems.
C1 [Nusslock, Robin; Miller, Gregory E.] Northwestern Univ, Dept Psychol, 2029 Sheridan Rd,Swift Hall, Evanston, IL 60202 USA.
   [Miller, Gregory E.] Northwestern Univ, Inst Policy Res, Evanston, IL 60202 USA.
C3 Northwestern University; Northwestern University
RP Miller, GE (corresponding author), Northwestern Univ, Dept Psychol, 2029 Sheridan Rd,Swift Hall, Evanston, IL 60202 USA.
EM greg.miller@northwestern.edu
OI Nusslock, Robin/0000-0001-6283-7824; Miller, Gregory/0000-0002-7217-1082
FU National Institute of Mental Health [R01 MH100117]; National Institute
   on Drug Abuse [P30 DA027827]; National Heart, Lung, and Blood Institute
   [R01 HL 122328]
FX Preparation of this article was supported by grants from the National
   Institute of Mental Health (Grant No. R01 MH100117), National Institute
   on Drug Abuse (Grant No. P30 DA027827), and National Heart, Lung, and
   Blood Institute (Grant No. R01 HL 122328).
CR Andersson IJ, 2009, AM J PHYSIOL-REG I, V296, pR663, DOI 10.1152/ajpregu.90768.2008
   Anisman H, 2009, J PSYCHIATR NEUROSCI, V34, P4
   Avitsur R, 2006, BRAIN BEHAV IMMUN, V20, P339, DOI 10.1016/j.bbi.2005.09.006
   Azad MB, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038669
   Blum K., 2000, J PSYCHOACTIVE DRUGS, V32, P1, DOI [DOI 10.1080/02791072.2000.10736099, 10.1080/02791072, DOI 10.1080/02791072]
   Bowirrat A, 2005, AM J MED GENET B, V132B, P29, DOI 10.1002/ajmg.b.30080
   Braveman PA, 2010, AM J PUBLIC HEALTH, V100, pS186, DOI 10.2105/AJPH.2009.166082
   Broyles ST, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0045419
   Capuron L, 2000, J CLIN ONCOL, V18, P2143, DOI 10.1200/JCO.2000.18.10.2143
   Capuron L, 2012, ARCH GEN PSYCHIAT, V69, P1044, DOI 10.1001/archgenpsychiatry.2011.2094
   Chen E, 2004, CHILD DEV, V75, P1039, DOI 10.1111/j.1467-8624.2004.00724.x
   Chen E, 2003, HEALTH PSYCHOL, V22, P106, DOI 10.1037/0278-6133.22.1.106
   Chen E, 2006, J ALLERGY CLIN IMMUN, V117, P1014, DOI 10.1016/j.jaci.2006.01.036
   Chen E, 2012, PERSPECT PSYCHOL SCI, V7, P135, DOI 10.1177/1745691612436694
   Cicchetti D, 2005, ANNU REV CLIN PSYCHO, V1, P409, DOI 10.1146/annurev.clinpsy.1.102803.144029
   CLOVER RD, 1989, J FAM PRACTICE, V28, P535
   Cohen S, 2013, BRAIN BEHAV IMMUN, V34, P31, DOI 10.1016/j.bbi.2013.06.009
   Coller JK, 2012, PHARMACOL THERAPEUT, V134, P219, DOI 10.1016/j.pharmthera.2012.01.008
   Costello EJ, 2013, DRUG ALCOHOL DEPEN, V133, P712, DOI 10.1016/j.drugalcdep.2013.08.027
   Danese A, 2014, MOL PSYCHIATR, V19, P544, DOI 10.1038/mp.2013.54
   Danese A, 2011, MOL PSYCHIATR, V16, P244, DOI 10.1038/mp.2010.5
   Danese A, 2008, ARCH GEN PSYCHIAT, V65, P409, DOI 10.1001/archpsyc.65.4.409
   Danese A, 2007, P NATL ACAD SCI USA, V104, P1319, DOI 10.1073/pnas.0610362104
   Danese A, 2012, PHYSIOL BEHAV, V106, P29, DOI 10.1016/j.physbeh.2011.08.019
   Danese A, 2009, ARCH PEDIAT ADOL MED, V163, P1135, DOI 10.1001/archpediatrics.2009.214
   Dannlowski U, 2013, HUM BRAIN MAPP, V34, P2899, DOI 10.1002/hbm.22112
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   Davis M, 2001, MOL PSYCHIATR, V6, P13, DOI 10.1038/sj.mp.4000812
   Dillon DG, 2009, BIOL PSYCHIAT, V66, P206, DOI 10.1016/j.biopsych.2009.02.019
   Dodge KA, 2006, DEV PSYCHOPATHOL, V18, P791, DOI 10.1017/S0954579406060391
   Dong MX, 2004, CIRCULATION, V110, P1761, DOI 10.1161/01.CIR.0000143074.54995.7F
   Doyle WJ, 2005, CURR ALLERGY ASTHM R, V5, P173, DOI 10.1007/s11882-005-0034-8
   Dube SR, 2009, PSYCHOSOM MED, V71, P243, DOI 10.1097/PSY.0b013e3181907888
   Edmiston EE, 2011, ARCH PEDIAT ADOL MED, V165, P1069, DOI 10.1001/archpediatrics.2011.565
   Eisenberger NI, 2010, BIOL PSYCHIAT, V68, P748, DOI 10.1016/j.biopsych.2010.06.010
   Elovainio M, 2012, SOC SCI MED, V74, P923, DOI 10.1016/j.socscimed.2011.12.017
   Enoch MA, 2011, PSYCHOPHARMACOLOGY, V214, P17, DOI 10.1007/s00213-010-1916-6
   Evans GW, 2004, AM PSYCHOL, V59, P77, DOI 10.1037/0003-066X.59.2.77
   Felitti VJ, 1998, AM J PREV MED, V14, P245, DOI 10.1016/S0749-3797(98)00017-8
   Frank MG, 2007, BRAIN BEHAV IMMUN, V21, P47, DOI 10.1016/j.bbi.2006.03.005
   Frank MG, 2011, BRAIN BEHAV IMMUN, V25, pS21, DOI 10.1016/j.bbi.2011.01.005
   Gabard-Durnam LJ, 2014, NEUROIMAGE, V95, P193, DOI 10.1016/j.neuroimage.2014.03.038
   Galobardes B, 2008, J EPIDEMIOL COMMUN H, V62, P387, DOI 10.1136/jech.2007.065508
   Galobardes B, 2006, ANN EPIDEMIOL, V16, P91, DOI 10.1016/j.annepidem.2005.06.053
   Gee DG, 2013, P NATL ACAD SCI USA, V110, P15638, DOI 10.1073/pnas.1307893110
   Gee DG, 2013, J NEUROSCI, V33, P4584, DOI 10.1523/JNEUROSCI.3446-12.2013
   Gianaros PJ, 2013, CEREB CORTEX, V23, P2058, DOI 10.1093/cercor/bhs191
   Gianaros PJ, 2011, CEREB CORTEX, V21, P896, DOI 10.1093/cercor/bhq160
   Goodman E, 2007, PSYCHOSOM MED, V69, P61, DOI 10.1097/01.psy.0000249732.96753.8f
   Guyer AE, 2006, J AM ACAD CHILD PSY, V45, P1059, DOI 10.1097/01.chi.0000227882.50404.11
   Haber SN, 2010, NEUROPSYCHOPHARMACOL, V35, P4, DOI 10.1038/npp.2009.129
   Handschin C, 2008, NATURE, V454, P463, DOI 10.1038/nature07206
   Hanson JL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0080954
   Hanson JL, 2012, J NEUROSCI, V32, P7917, DOI 10.1523/JNEUROSCI.0307-12.2012
   Haroon E, 2012, NEUROPSYCHOPHARMACOL, V37, P137, DOI 10.1038/npp.2011.205
   Harrison NA, 2009, BIOL PSYCHIAT, V66, P407, DOI 10.1016/j.biopsych.2009.03.015
   Herringa RJ, 2013, P NATL ACAD SCI USA, V110, P19119, DOI 10.1073/pnas.1310766110
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Hutchinson MR, 2011, PHARMACOL REV, V63, P772, DOI 10.1124/pr.110.004135
   Inagaki TK, 2012, NEUROIMAGE, V59, P3222, DOI 10.1016/j.neuroimage.2011.10.090
   Irwin MR, 2011, NAT REV IMMUNOL, V11, P625, DOI 10.1038/nri3042
   Johnson PM, 2010, NAT NEUROSCI, V13, P635, DOI 10.1038/nn.2519
   Johnson RC, 2011, AM J PUBLIC HEALTH, V101, P2317, DOI 10.2105/AJPH.2011.300252
   Keinan-Boker L, 2009, JNCI-J NATL CANCER I, V101, P1489, DOI 10.1093/jnci/djp327
   Khandaker GM, 2014, JAMA PSYCHIAT, V71, P1121, DOI 10.1001/jamapsychiatry.2014.1332
   Kiecolt-Glaser JK, 2011, PSYCHOSOM MED, V73, P16, DOI 10.1097/PSY.0b013e31820573b6
   Kiecolt-Glaser JK, 2010, PSYCHOSOM MED, V72, P365, DOI 10.1097/PSY.0b013e3181dbf489
   Kim P, 2013, P NATL ACAD SCI USA, V110, P18442, DOI 10.1073/pnas.1308240110
   Kivimäki M, 2006, HEART, V92, P474, DOI 10.1136/hrt.2005.067108
   Langenberg C, 2006, AM J PUBLIC HEALTH, V96, P2216, DOI 10.2105/AJPH.2004.049429
   Lawlor DA, 2006, AM J EPIDEMIOL, V164, P907, DOI 10.1093/aje/kwj319
   Lawson GM, 2013, DEVELOPMENTAL SCI, V16, P641, DOI 10.1111/desc.12096
   Lee FS, 2014, SCIENCE, V346, P547, DOI 10.1126/science.1260497
   Lehman BJ, 2005, PSYCHOSOM MED, V67, P846, DOI 10.1097/01.psy.0000188443.48405.eb
   Leppänen JM, 2009, NAT REV NEUROSCI, V10, P37, DOI 10.1038/nrn2554
   Libby P, 2009, J AM COLL CARDIOL, V54, P2129, DOI 10.1016/j.jacc.2009.09.009
   Loucks EB, 2010, SOC SCI MED, V71, P187, DOI 10.1016/j.socscimed.2010.03.012
   Luby J, 2013, JAMA PEDIATR, V167, P1135, DOI 10.1001/jamapediatrics.2013.3139
   Lupien SJ, 2009, NAT REV NEUROSCI, V10, P434, DOI 10.1038/nrn2639
   Maier SF, 1998, PSYCHOL REV, V105, P83, DOI 10.1037/0033-295X.105.1.83
   Mantovani A, 2008, NATURE, V454, P436, DOI 10.1038/nature07205
   Marsland AL, 2008, BIOL PSYCHIAT, V64, P484, DOI 10.1016/j.biopsych.2008.04.016
   Matthews K, 2003, NEUROSCI BIOBEHAV R, V27, P45, DOI 10.1016/S0149-7634(03)00008-3
   Matthews KA, 2014, BRAIN BEHAV IMMUN, V36, P29, DOI 10.1016/j.bbi.2013.09.013
   Matthews KA, 2011, SOC SCI MED, V73, P768, DOI 10.1016/j.socscimed.2011.06.017
   Matthews KA, 2010, BRAIN BEHAV IMMUN, V24, P96, DOI 10.1016/j.bbi.2009.08.005
   McCrory EJ, 2013, BRIT J PSYCHIAT, V202, P269, DOI 10.1192/bjp.bp.112.116624
   McEwen BS, 2010, ANN NY ACAD SCI, V1186, P190, DOI 10.1111/j.1749-6632.2009.05331.x
   McLaughlin KA, 2012, ARCH GEN PSYCHIAT, V69, P1151, DOI 10.1001/archgenpsychiatry.2011.2277
   Mehta MA, 2010, J COGNITIVE NEUROSCI, V22, P2316, DOI 10.1162/jocn.2009.21394
   Melchior M, 2007, AM J EPIDEMIOL, V166, P966, DOI 10.1093/aje/kwm155
   Meyer U, 2013, PROG NEURO-PSYCHOPH, V42, P20, DOI 10.1016/j.pnpbp.2011.11.003
   Midei AJ, 2013, HEALTH PSYCHOL, V32, P121, DOI 10.1037/a0027891
   Miller AH, 2013, DEPRESS ANXIETY, V30, P297, DOI 10.1002/da.22084
   Miller AH, 2009, BIOL PSYCHIAT, V65, P732, DOI 10.1016/j.biopsych.2008.11.029
   Miller GE, 2012, BIOL PSYCHIAT, V72, P34, DOI 10.1016/j.biopsych.2012.02.034
   Miller GE, 2011, PSYCHOL SCI, V22, P1591, DOI 10.1177/0956797611419170
   Miller GE, 2011, PSYCHOL BULL, V137, P959, DOI 10.1037/a0024768
   Miller GE, 2010, PSYCHOL SCI, V21, P848, DOI 10.1177/0956797610370161
   Miller GE, 2009, P NATL ACAD SCI USA, V106, P14716, DOI 10.1073/pnas.0902971106
   Musselman DL, 2001, NEW ENGL J MED, V344, P961, DOI 10.1056/NEJM200103293441303
   Nathan C, 2010, CELL, V140, P871, DOI 10.1016/j.cell.2010.02.029
   Noble KG, 2012, DEVELOPMENTAL SCI, V15, P516, DOI 10.1111/j.1467-7687.2012.01147.x
   Odegaard JI, 2013, SCIENCE, V339, P172, DOI 10.1126/science.1230721
   PHILLIPS GD, 1994, PSYCHOPHARMACOLOGY, V115, P419, DOI 10.1007/BF02245085
   Phillips M, 2008, MOL PSYCHIATR, V13, P833, DOI 10.1038/mp.2008.65
   Pollak SD, 2003, J ABNORM PSYCHOL, V112, P323, DOI 10.1037/0021-843X.112.3.323
   Pollak SD, 2002, P NATL ACAD SCI USA, V99, P9072, DOI 10.1073/pnas.142165999
   Pollak SD, 2002, DEV PSYCHOL, V38, P784, DOI 10.1037/0012-1649.38.5.784
   Pollak SD, 2008, CURR DIR PSYCHOL SCI, V17, P370, DOI 10.1111/j.1467-8721.2008.00608.x
   Prescott SL, 2006, PAEDIATR RESPIR REV, V7, P89, DOI 10.1016/j.prrv.2006.03.001
   Price JL, 2010, NEUROPSYCHOPHARMACOL, V35, P192, DOI 10.1038/npp.2009.104
   Pryce CR, 2004, BIOL PSYCHIAT, V56, P72, DOI 10.1016/j.biopsych.2004.05.002
   Raison CL, 2013, JAMA PSYCHIAT, V70, P31, DOI 10.1001/2013.jamapsychiatry.4
   Raison CL, 2003, AM J PSYCHIAT, V160, P1554, DOI 10.1176/appi.ajp.160.9.1554
   Reiss F, 2013, SOC SCI MED, V90, P24, DOI 10.1016/j.socscimed.2013.04.026
   Rich-Edwards JW, 2012, CIRCULATION, V126, P920, DOI 10.1161/CIRCULATIONAHA.111.076877
   Ridker PM, 2007, NUTR REV, V65, pS253, DOI 10.1301/nr.2007.dec.S253-S259
   Rodrigues SM, 2009, ANNU REV NEUROSCI, V32, P289, DOI 10.1146/annurev.neuro.051508.135620
   Rook GAW, 2014, CLIN EXP IMMUNOL, V177, P1, DOI 10.1111/cei.12269
   Sapolsky RM, 2000, ENDOCR REV, V21, P55, DOI 10.1210/er.21.1.55
   Satizabal CL, 2012, NEUROLOGY, V78, P720, DOI 10.1212/WNL.0b013e318248e50f
   Schreier HMC, 2014, PSYCHOSOM MED, V76, P460, DOI 10.1097/PSY.0000000000000078
   Schreier HMC, 2010, BRAIN BEHAV IMMUN, V24, P1324, DOI 10.1016/j.bbi.2010.06.007
   Scrivo R, 2011, AUTOIMMUN REV, V10, P369, DOI 10.1016/j.autrev.2010.12.006
   Shankardass K, 2009, P NATL ACAD SCI USA, V106, P12406, DOI 10.1073/pnas.0812910106
   Sheridan MA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035744
   Shonkoff JP, 2009, JAMA-J AM MED ASSOC, V301, P2252, DOI 10.1001/jama.2009.754
   Slavich GM, 2014, PSYCHOL BULL, V140, P774, DOI 10.1037/a0035302
   Slopen N, 2013, PSYCHONEUROENDOCRINO, V38, P188, DOI 10.1016/j.psyneuen.2012.05.013
   Sternberg EM, 2006, NAT REV IMMUNOL, V6, P318, DOI 10.1038/nri1810
   Stewart JC, 2009, BRAIN BEHAV IMMUN, V23, P936, DOI 10.1016/j.bbi.2009.04.011
   Stice E, 2008, SCIENCE, V322, P449, DOI 10.1126/science.1161550
   Taylor SE, 2006, BIOL PSYCHIAT, V60, P296, DOI 10.1016/j.biopsych.2005.09.027
   Teicher MH, 2013, AM J PSYCHIAT, V170, P1114, DOI 10.1176/appi.ajp.2013.12070957
   Thurston RC, 2014, STROKE, V45, P2246, DOI 10.1161/STROKEAHA.114.005928
   Tottenham N, 2011, DEVELOPMENTAL SCI, V14, P190, DOI 10.1111/j.1467-7687.2010.00971.x
   van Harmelen AL, 2013, SOC COGN AFFECT NEUR, V8, P362, DOI 10.1093/scan/nss007
   Volkow N D, 2012, Curr Top Behav Neurosci, V11, P1, DOI 10.1007/7854_2011_169
   Volkow ND, 2003, J CLIN INVEST, V111, P1444, DOI 10.1172/JCI200318533
   Volkow ND, 2007, ARCH NEUROL-CHICAGO, V64, P1575, DOI 10.1001/archneur.64.11.1575
   Webster JI, 2002, ANNU REV IMMUNOL, V20, P125, DOI 10.1146/annurev.immunol.20.082401.104914
   Widom CS, 2007, J STUD ALCOHOL DRUGS, V68, P317, DOI 10.15288/jsad.2007.68.317
   Wohleb ES, 2013, J NEUROSCI, V33, P13820, DOI 10.1523/JNEUROSCI.1671-13.2013
   Wohleb ES, 2011, J NEUROSCI, V31, P6277, DOI 10.1523/JNEUROSCI.0450-11.2011
   Wright RJ, 2004, AM J PUBLIC HEALTH, V94, P625, DOI 10.2105/AJPH.94.4.625
   Wright RJ, 2010, AM J RESP CRIT CARE, V182, P25, DOI 10.1164/rccm.200904-0637OC
   Yanbaeva DG, 2007, CHEST, V131, P1557, DOI 10.1378/chest.06-2179
   Ziol-Guest KM, 2012, P NATL ACAD SCI USA, V109, P17289, DOI 10.1073/pnas.1203167109
NR 149
TC 445
Z9 511
U1 7
U2 246
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD JUL 1
PY 2016
VL 80
IS 1
BP 23
EP 32
DI 10.1016/j.biopsych.2015.05.017
PG 10
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA DO8TB
UT WOS:000378055600009
PM 26166230
OA Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Auvinen, P
   Mäntyselkä, P
   Koponen, H
   Kautiainen, H
   Korniloff, K
   Ahonen, T
   Vanhala, M
AF Auvinen, Piritta
   Mantyselka, Pekka
   Koponen, Hannu
   Kautiainen, Hannu
   Korniloff, Katariina
   Ahonen, Tiina
   Vanhala, Mauno
TI Prevalence of restless legs symptoms according to depressive symptoms
   and depression type: a cross-sectional study
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Restless legs syndrome; depressive disorder; melancholia; depression;
   primary health care
ID WILLIS-EKBOM DISEASE; CLINICAL CHARACTERISTICS; GENERAL-POPULATION;
   METABOLIC SYNDROME; PRIMARY-CARE; RISK-FACTORS; SYNDROME RLS; ADULTS;
   EPIDEMIOLOGY; ASSOCIATION
AB Background: Restless legs syndrome is a sensorimotor disorder and it is associated with several other diseases especially mental illnesses.Aims: To analyze the relationship between the symptoms of restless legs syndrome and the severity of depressive symptoms and the prevalence of restless legs symptoms in depression subtypes.Methods: A cross-sectional study of primary care patients in the Central Finland Hospital District. The prevalence of restless legs symptoms was studied in 706 patients with increased depressive symptoms and 426 controls without a psychiatric diagnosis by using a structured questionnaire. The depressive symptoms were evaluated with the Beck Depression Inventory (BDI) and the psychiatric diagnosis was confirmed by means of a diagnostic interview (Mini-International Neuropsychiatric Interview). The subjects with increased depressive symptoms were divided into three groups (subjects with depressive symptoms without a depression diagnosis, melancholic depression and non-melancholic depression).Results: In the whole study population, the prevalence of restless legs symptoms increased with the severity of depressive symptoms. The prevalence of restless legs symptoms was highest in the melancholic and non-melancholic depressive patients (52 and 46%, respectively) and then in subjects with depressive symptoms without a depression diagnosis (43.4%), but the prevalence was also substantial (24.6%) in subjects without a psychiatric diagnosis.Conclusions: Restless legs symptoms are very common in primary care among subjects with depression, regardless of the depression type. The prevalence of restless legs symptoms increased with increasing severity of depressive symptoms, regardless of the diagnosis. These findings should be considered in clinical evaluation and treatment of patients visiting their physician due to restless legs or depressive symptoms.
C1 [Auvinen, Piritta; Mantyselka, Pekka] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Gen Practice Unit, POB 1627, FI-70211 Kuopio, Finland.
   [Mantyselka, Pekka] Kuopio Univ Hosp, Primary Hlth Care Unit, Kuopio, Finland.
   [Koponen, Hannu] Univ Helsinki, Dept Psychiat, Helsinki, Finland.
   [Koponen, Hannu] Helsinki Univ Hosp, Helsinki, Finland.
   [Kautiainen, Hannu] Kuopio Univ Hosp, Primary Hlth Care Unit, Kuopio, Finland.
   [Kautiainen, Hannu] Univ Helsinki, Unit Primary Hlth Care, Cent Hosp, Helsinki, Finland.
   [Kautiainen, Hannu] Univ Helsinki, Dept Gen Practice, Helsinki, Finland.
   [Korniloff, Katariina] JAMK Univ Appl Sci, Sch Hlth & Social Studies, Jyvaskyla, Finland.
   [Ahonen, Tiina] Cent Finland Cent Hosp, Primary Hlth Care Unit, Jyvaskyla, Finland.
   [Vanhala, Mauno] Cent Finland Cent Hosp, Jyvaskyla, Finland.
C3 University of Eastern Finland; Kuopio University Hospital; University of
   Eastern Finland; University of Eastern Finland Hospital; University of
   Helsinki; University of Helsinki; Helsinki University Central Hospital;
   Kuopio University Hospital; University of Eastern Finland; University of
   Eastern Finland Hospital; University of Helsinki; Helsinki University
   Central Hospital; University of Helsinki; Jyvaskyla University of
   Applied Sciences; Central Finland Central Hospital; Central Finland
   Central Hospital
RP Auvinen, P (corresponding author), Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Gen Practice Unit, POB 1627, FI-70211 Kuopio, Finland.
EM pirau@student.uef.fi
OI Koponen, Hannu/0000-0002-7368-1869; Korniloff,
   Katariina/0000-0002-0753-1483
FU Central Finland Hospital District; Northern Savo Hospital District;
   Central Finland Health Care District
FX This study was supported by the Central Finland Hospital District, the
   Northern Savo Hospital District and Central Finland Health Care
   District.
CR Allen RP, 2014, NEW ENGL J MED, V370, P621, DOI 10.1056/NEJMoa1303646
   Allen RP, 2010, SLEEP MED, V11, P31, DOI 10.1016/j.sleep.2009.03.007
   Allen RP, 2003, SLEEP MED, V4, P101, DOI 10.1016/S1389-9457(03)00010-8
   Allen RP, 2005, ARCH INTERN MED, V165, P1286, DOI 10.1001/archinte.165.11.1286
   BECK AT, 1961, COMPR PSYCHIAT, V2, P163, DOI 10.1016/S0010-440X(61)80020-5
   Benediktsdottir B, 2010, SLEEP MED, V11, P1043, DOI 10.1016/j.sleep.2010.08.006
   Bogan RK, 2015, ANN MED, V47, P269, DOI 10.3109/07853890.2015.1025825
   De Vito K, 2014, MOVEMENT DISORD, V29, P1044, DOI 10.1002/mds.25860
   Earley CJ, 2010, SLEEP MED, V11, P807, DOI 10.1016/j.sleep.2010.07.007
   Ferri R, 2007, EUR J NEUROL, V14, P1016, DOI 10.1111/j.1468-1331.2007.01862.x
   Garcia-Borreguero D, 2013, SLEEP MED, V14, P675, DOI 10.1016/j.sleep.2013.05.016
   Happe S, 2008, J NEUROL, V255, P1365, DOI 10.1007/s00415-008-0922-7
   Happe S, 2009, SLEEP MED, V10, P295, DOI 10.1016/j.sleep.2008.01.002
   Harald B, 2012, J AFFECT DISORDERS, V139, P126, DOI 10.1016/j.jad.2011.07.015
   Hening W, 2004, SLEEP MED, V5, P237, DOI 10.1016/j.sleep.2004.03.006
   Hening Wayne A, 2002, Curr Neurol Neurosci Rep, V2, P186, DOI 10.1007/s11910-002-0029-y
   Hornyak M, 2005, J CLIN PSYCHIAT, V66, P1139, DOI 10.4088/JCP.v66n0909
   Jones R, 2013, BEHAV NEUROL, V26, P283, DOI [10.3233/BEN-2012-120271, 10.1155/2013/585439]
   Juuti AK, 2010, ACTA NEUROL SCAND, V122, P63, DOI 10.1111/j.1600-0404.2009.01262.x
   Kim WH, 2012, INT J GERIATR PSYCH, V27, P565, DOI 10.1002/gps.2754
   Koponen H, 2015, NORD J PSYCHIAT, V69, P262, DOI 10.3109/08039488.2014.972451
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Mackie S, 2015, CNS DRUGS, V29, P351, DOI 10.1007/s40263-015-0250-2
   Müller MJ, 2016, NORD J PSYCHIAT, V70, P329, DOI 10.3109/08039488.2015.1112832
   Nichols DA, 2003, ARCH INTERN MED, V163, P2323, DOI 10.1001/archinte.163.19.2323
   Nomura T, 2008, MOVEMENT DISORD, V23, P2363, DOI 10.1002/mds.22274
   Ohayon MM, 2002, J PSYCHOSOM RES, V53, P547, DOI 10.1016/S0022-3999(02)00443-9
   Ondo W, 1996, NEUROLOGY, V47, P1435, DOI 10.1212/WNL.47.6.1435
   Ovaskainen Y, 2009, PSYCHIAT RES, V167, P73, DOI 10.1016/j.psychres.2007.12.004
   Pettersson A, 2015, NORD J PSYCHIAT, V69, P497, DOI 10.3109/08039488.2015.1008568
   Phillips B, 2000, ARCH INTERN MED, V160, P2137, DOI 10.1001/archinte.160.14.2137
   Salminen AV, 2014, NEUROLOGY, V82, P1856, DOI 10.1212/WNL.0000000000000454
   Schlesinger I, 2009, MOVEMENT DISORD, V24, P1587, DOI 10.1002/mds.22486
   Seppälä J, 2012, J AFFECT DISORDERS, V136, P543, DOI 10.1016/j.jad.2011.10.032
   Sheehan D.V., 1994, MINI INT NEUROPSYCHI
   Stiasny-Kolster K, 2004, J NEUROL, V251, P39, DOI 10.1007/s00415-004-1609-3
   Szentkiralyi A, 2013, PSYCHOSOM MED, V75, P359, DOI 10.1097/PSY.0b013e31828bbbf1
   Takahashi M, 2015, SLEEP MED, V16, P871, DOI 10.1016/j.sleep.2015.03.006
   Taylor M, 2002, MELANCHOLIA CLIN GUI
   Teychenne M, 2008, PREV MED, V46, P397, DOI 10.1016/j.ypmed.2008.01.009
   Trenkwalder C, 2004, CLIN NEUROPHYSIOL, V115, P1975, DOI 10.1016/j.clinph.2004.01.031
   Tzonova D, 2012, SLEEP MED, V13, P151, DOI 10.1016/j.sleep.2011.09.015
   Ulfberg J, 2001, MOVEMENT DISORD, V16, P1159, DOI 10.1002/mds.1209
   Ulfberg J, 2007, SLEEP MED, V8, P768, DOI 10.1016/j.sleep.2006.11.015
   Vanhala M, 2009, ACTA PSYCHIAT SCAND, V119, P137, DOI 10.1111/j.1600-0447.2008.01283.x
   Wesström J, 2008, CLIMACTERIC, V11, P422, DOI 10.1080/13697130802359683
   Winkelmann J, 2005, J NEUROL, V252, P67, DOI 10.1007/s00415-005-0604-7
   Winkelmann J, 2007, NAT GENET, V39, P1000, DOI 10.1038/ng2099
NR 48
TC 12
Z9 12
U1 0
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0803-9488
EI 1502-4725
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PY 2018
VL 72
IS 1
BP 51
EP 56
DI 10.1080/08039488.2017.1385849
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FP7UY
UT WOS:000417846400008
PM 28990833
DA 2025-06-11
ER

PT J
AU Gurudev, S
   Pise, G
   Manohar, N
   Sanagoudar, V
   Rao, K
   Patil, MN
AF Gurudev, Shradha
   Pise, Gajanan
   Manohar, Naveen
   Sanagoudar, Vinitha
   Rao, Kiran
   Patil, Malteshgauda N.
TI Clinico-Epidemiological Study of Papulosquamous Disorders in Childhood
   at a Tertiary Care Hospital in South India
SO INDIAN JOURNAL OF PAEDIATRIC DERMATOLOGY
LA English
DT Article
DE Anthropometry; child; metabolic syndrome; papulosquamous disorders;
   psoriasis
ID LICHEN-STRIATUS; METABOLIC SYNDROME; PSORIASIS; CHILDREN; DERMATOSES;
   FEATURES; DISEASES; INFANTS; PATTERN; PLANUS
AB Introduction: Papulosquamous disorders in children differ from those in adults in terms of presentations, treatments, and prognosis. The aim of this study was to add to the existing data regarding the presentation of pediatric papulosquamous disorders and analyze the metabolic parameters in children with psoriasis. Materials and Methods: This observational study included 83 patients (age, 0-18 years) with clinically diagnosed papulosquamous disorders. Demographic data and detailed clinical history were collected followed by a detailed clinical examination. In children with psoriasis, we assessed the parameters of metabolic health, such as anthropometry and blood chemistry. The outcomes are expressed as percentages and proportions. Results: Papulosquamous disorders constituted 2.3% of all the pediatric dermatoses with a male-to-female ratio of 1.7:1. They were commonly noted in the age group of 7-12 years. Psoriasis vulgaris (26.5%) was the most common disease followed by lichen planus (19.2%), seborrheic dermatitis (16.8%), pityriasis rosea (13.2%), lichen striatus (12%), lichen nitidus (7.2%), pityriasis lichenoides chronica (3.6%), and pityriasis rubra pilaris (1.20%). None of the 22 patients with psoriasis fulfilled the criteria for metabolic syndrome. However, aberrant serum levels included elevated fasting glucose (n = 5, 22.7%), elevated fasting triglycerides (n = 3, 13.6%), and decreased high-density lipoproteins (n = 2, 9.1%). Anthropometric abnormalities were also not noted. Conclusions: Understanding the morphological and epidemiological features of pediatric papulosquamous disorders can aid in early diagnosis, treatment, and counseling the patients and parents, which can alleviate their anxiety and improve the psychological distress.
C1 [Gurudev, Shradha; Pise, Gajanan; Manohar, Naveen; Sanagoudar, Vinitha; Rao, Kiran; Patil, Malteshgauda N.] Belagavi Inst Med Sci, Head Dept Dermatol, Belagavi, India.
RP Pise, G (corresponding author), Belagavi Inst Med Sci, Dept Dermatol, Room 24,Dr. BR Ambedkar Rd, Belagavi 590001, India.
EM gajananpise@gmail.com
RI Manohar, Naveen/IAO-3584-2023
CR Abagge KT, 2004, PEDIATR DERMATOL, V21, P440, DOI 10.1111/j.0736-8046.2004.21403.x
   Adhicari P, 2016, Int Organ Sci Res J Dent Med Sci, V15, P10
   Al-Mendalawi M. D., 2012, Eastern Mediterranean Health Journal, V18, P365
   ALFOUZAN AS, 1994, PEDIATR DERMATOL, V11, P116, DOI 10.1111/j.1525-1470.1994.tb00563.x
   Banerjee Sabyasachi, 2010, Indian J Dermatol, V55, P44, DOI 10.4103/0019-5154.60351
   Blauvelt A, Fitzpatrick's Dermatology in General Medicine, V7th
   Capella GL, 2000, CLIN DERMATOL, V18, P701, DOI 10.1016/S0738-081X(00)00155-3
   Chatproedprai Susheera, 2008, Journal of the Medical Association of Thailand, V91, P1356
   Das S., 2017, INDIAN J PAEDIATR DE, V18, P89
   Dogra S, 2003, PEDIATR DERMATOL, V20, P470, DOI 10.1111/j.1525-1470.2003.20602.x
   Dogra S, 2010, INDIAN J DERMATOL VE, V76, P357, DOI 10.4103/0378-6323.66580
   Elfaituri S S., 2015, Indian J Paediatr Dermatol, V16, P64
   Ersoy-Evans S, 2007, J AM ACAD DERMATOL, V56, P205, DOI 10.1016/j.jaad.2006.08.023
   Foley P, 2003, ARCH DERMATOL, V139, P318, DOI 10.1001/archderm.139.3.318
   Goldminz AM, 2013, PEDIATR DERMATOL, V30, P700, DOI 10.1111/pde.12218
   Gül Ü, 2008, PEDIATR DERMATOL, V25, P277, DOI 10.1111/j.1525-1470.2008.00656.x
   Gündüz Ö, 2009, PEDIATR DERMATOL, V26, P750, DOI 10.1111/j.1525-1470.2009.00866.x
   Handa S, 2002, INT J DERMATOL, V41, P423, DOI 10.1046/j.1365-4362.2002.01522.x
   Hauber K, 2000, EUR J DERMATOL, V10, P536
   Hebert AA, 1996, Contemp Pediatr, V13, P69
   Kanwar AJ, 2010, CLIN EXP DERMATOL, V35, P257, DOI 10.1111/j.1365-2230.2009.03613.x
   Karthikeyan Kaliaperumal, 2004, Indian Pediatr, V41, P373
   Kumar B, 2004, INT J DERMATOL, V43, P654, DOI 10.1111/j.1365-4632.2004.02182.x
   Kumar Vijay, 1993, Journal of Dermatology (Tokyo), V20, P175
   LAPINS NA, 1978, CUTIS, V21, P634
   Morris A, 2001, PEDIATR DERMATOL, V18, P188, DOI 10.1046/j.1525-1470.2001.018003188.x
   Nair PS, 2007, INDIAN J DERMATOL VE, V73, P100, DOI 10.4103/0378-6323.31894
   NANDA A, 1990, PEDIATR DERMATOL, V7, P19, DOI 10.1111/j.1525-1470.1990.tb01067.x
   NYFORS A, 1975, BRIT J DERMATOL, V92, P437, DOI 10.1111/j.1365-2133.1975.tb03105.x
   Patrizi A, 2004, PEDIATR DERMATOL, V21, P197, DOI 10.1111/j.0736-8046.2004.21302.x
   Pietrzak A, 2017, CLIN EXP DERMATOL, V42, P131, DOI 10.1111/ced.13014
   Sacchidanand S, 2014, INDIAN J PEDIATR, V81, P375, DOI 10.1007/s12098-012-0904-8
   Sterling J., 2004, Textbook of Dermatology, V7th, P79
   Taieb A., 2006, Textbook of Pediatric Dermatology, V2nd, P813
   Torres T, 2014, EUR J DERMATOL, V24, P229, DOI 10.1684/ejd.2014.2291
   Vetrichewel TP., 2006, 34 NATL C INDIAN ASS, P333
   Zapata Roman G, 1981, Med Cutan Ibero Lat Am, V9, P323
NR 37
TC 1
Z9 1
U1 0
U2 0
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 2319-7250
EI 2319-7269
J9 INDIAN J PAEDIATR DE
JI Indian J. Paediatr. Dermatol.
PD APR-JUN
PY 2023
VL 24
IS 2
BP 121
EP 128
DI 10.4103/ijpd.ijpd_50_22
PG 8
WC Dermatology; Pediatrics
WE Emerging Sources Citation Index (ESCI)
SC Dermatology; Pediatrics
GA Y6XQ6
UT WOS:001106675400003
OA gold
DA 2025-06-11
ER

PT J
AU Shen, BJ
   Farrell, KA
   Penedo, FJ
   Schneiderman, N
   Orth-Gomer, K
AF Shen, Biing-Jiun
   Farrell, Kristen A.
   Penedo, Frank J.
   Schneiderman, Neil
   Orth-Gomer, Kristina
TI Waist Circumference Moderates the Association Between Marital Stress and
   C-reactive Protein in Middle-Aged Healthy Women
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Article
DE C-reactive protein; Marital stress; Waist circumference; Apolipoprotein;
   Women
ID SOCIOECONOMIC-STATUS; PSYCHOSOCIAL STRESS; METABOLIC SYNDROME;
   APOLIPOPROTEIN-B; OBESE SUBJECTS; INFLAMMATION; RESPONSES; RISK;
   INTERLEUKIN-6; ATHEROSCLEROSIS
AB The relationships among stress, obesity, and inflammation in women remain unclear. This study examined the relationships among marital stress, waist circumference, and C-reactive protein (CRP) in 201 healthy women from the Stockholm Female Coronary Risk Study. We tested whether marital stress was associated with CRP and whether this association was moderated by waist circumference. Hierarchical multiple regression revealed that after adjusting for age, occupation status, fasting glucose, apolipoprotein A1, apolipoprotein B, blood pressure, smoking, and menopausal status, marital stress was not directly associated with CRP. However, waist circumference significantly moderated the association between marital stress and CRP (p=0.012) such that marital stress was significantly associated with higher CRP among women with larger waist circumferences but not in those with smaller waists. More obese women may be particularly vulnerable to the effects of marital stress by manifesting higher inflammation.
C1 [Shen, Biing-Jiun] Univ So Calif, Dept Psychol, Los Angeles, CA 90089 USA.
   [Farrell, Kristen A.; Penedo, Frank J.; Schneiderman, Neil] Univ Miami, Miami, FL USA.
   [Orth-Gomer, Kristina] Karolinska Inst, Stockholm, Sweden.
   [Orth-Gomer, Kristina] Free & Humboldt Univ, Charite Univ Med, Berlin, Germany.
C3 University of Southern California; University of Miami; Karolinska
   Institutet; Berlin Institute of Health; Free University of Berlin;
   Humboldt University of Berlin; Charite Universitatsmedizin Berlin
RP Shen, BJ (corresponding author), Univ So Calif, Dept Psychol, 3620 S McClintock Ave,SGM 501, Los Angeles, CA 90089 USA.
EM bjshen@usc.edu
RI She, Ji/AAW-6150-2021
CR [Anonymous], 2002, APPL MULTIPLE REGRES, DOI DOI 10.4324/9780203774441
   Benson S, 2009, PSYCHONEUROENDOCRINO, V34, P727, DOI 10.1016/j.psyneuen.2008.12.001
   Benson S, 2009, PSYCHONEUROENDOCRINO, V34, P181, DOI 10.1016/j.psyneuen.2008.08.019
   Black PH, 2002, BRAIN BEHAV IMMUN, V16, P622, DOI 10.1016/S0889-1591(02)00021-1
   Bonnet F, 2005, ATHEROSCLEROSIS, V178, P339, DOI 10.1016/j.atherosclerosis.2004.08.035
   Brotman DJ, 2005, J CLIN ENDOCR METAB, V90, P3202, DOI 10.1210/jc.2004-2379
   Brummett BH, 2010, PSYCHOSOM MED, V72, P333, DOI 10.1097/PSY.0b013e3181d2f104
   Cizza G, 2009, HORM METAB RES, V41, P641, DOI 10.1055/s-0029-1220717
   Davis MC, 2008, BRAIN BEHAV IMMUN, V22, P24, DOI 10.1016/j.bbi.2007.06.013
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Drapeau V, 2003, PANMINERVA MED, V45, P189
   Faraj M, 2006, DIABETOLOGIA, V49, P1637, DOI 10.1007/s00125-006-0259-7
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Fried SK, 1998, J CLIN ENDOCR METAB, V83, P847, DOI 10.1210/jc.83.3.847
   Gallinelli A, 2000, FERTIL STERIL, V73, P812, DOI 10.1016/S0015-0282(99)00601-9
   García-Lorda P, 2006, INT J OBESITY, V30, P468, DOI 10.1038/sj.ijo.0803182
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hamer M, 2008, PHYSIOL BEHAV, V94, P536, DOI 10.1016/j.physbeh.2008.03.010
   JUNGNER I, 1992, INT J CLIN LAB RES, V21, P247, DOI 10.1007/BF02591655
   KIDDY DS, 1990, CLIN ENDOCRINOL, V32, P213, DOI 10.1111/j.1365-2265.1990.tb00857.x
   Kiecolt-Glaser JK, 2005, ARCH GEN PSYCHIAT, V62, P1377, DOI 10.1001/archpsyc.62.12.1377
   Koster A, 2008, AM J EPIDEMIOL, V167, P1465, DOI 10.1093/aje/kwn079
   Langelaan S, 2007, INT J BEHAV MED, V14, P213, DOI 10.1007/BF03002995
   Li JJ, 2004, MED HYPOTHESES, V62, P499, DOI 10.1016/j.mehy.2003.12.014
   Libby P, 2006, AM J CLIN NUTR, V83, p456S
   Libby P, 2004, AM J MED, V116, P9, DOI 10.1016/j.amjmed.2004.02.006
   Matthews KA, 2010, BRAIN BEHAV IMMUN, V24, P96, DOI 10.1016/j.bbi.2009.08.005
   McDade TW, 2006, PSYCHOSOM MED, V68, P376, DOI 10.1097/01.psy.0000221371.43607.64
   Melamed S, 2004, PSYCHOSOM MED, V66, P484, DOI 10.1097/01.psy.0000130963.52755.b9
   Nabi H, 2008, ARTERIOSCL THROM VAS, V28, P1398, DOI 10.1161/ATVBAHA.108.167239
   Orth-Gomer K, 1997, Lakartidningen, V94, P635
   OrthGomer K, 1997, CIRCULATION, V95, P329
   ORTHGOMER K, 2000, JAMA-J AM MED ASSOC, V294, P3008
   Owen N, 2003, BRAIN BEHAV IMMUN, V17, P286, DOI 10.1016/S0889-1591(03)00058-8
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Raison CL, 2003, AM J PSYCHIAT, V160, P1554, DOI 10.1176/appi.ajp.160.9.1554
   Ranjit N, 2007, ARCH INTERN MED, V167, P174, DOI 10.1001/archinte.167.2.174
   Ridker PM, 1999, CIRCULATION, V100, P713, DOI 10.1161/01.CIR.100.7.713
   RIEPPONEN P, 1987, SCAND J CLIN LAB INV, V47, P739
   Rohrer L, 2004, CURR OPIN LIPIDOL, V15, P269, DOI 10.1097/00041433-200406000-00006
   Stewart JC, 2008, PSYCHOSOM MED, V70, P197, DOI 10.1097/PSY.0b013e3181642a0b
   von Känel R, 2008, J THROMB THROMBOLYS, V25, P165, DOI 10.1007/s11239-007-0035-7
   Wamala SP, 1999, ARTERIOSCL THROM VAS, V19, P485, DOI 10.1161/01.ATV.19.3.485
   Wamala SP, 1999, DIABETES CARE, V22, P1999, DOI 10.2337/diacare.22.12.1999
NR 44
TC 14
Z9 18
U1 0
U2 6
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD DEC
PY 2010
VL 40
IS 3
BP 258
EP 264
DI 10.1007/s12160-010-9211-7
PG 7
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA 717JZ
UT WOS:000287041100003
PM 20658213
OA Bronze
DA 2025-06-11
ER

PT J
AU McCrindle, BW
AF McCrindle, Brian W.
TI Cardiovascular Consequences of Childhood Obesity
SO CANADIAN JOURNAL OF CARDIOLOGY
LA English
DT Review
ID TYPE-2 DIABETES-MELLITUS; INTIMA-MEDIA THICKNESS; BODY-MASS INDEX;
   RISK-FACTORS; PHYSICAL-ACTIVITY; BLOOD-PRESSURE; WEIGHT-GAIN; SCIENTIFIC
   STATEMENT; VASCULAR DYSFUNCTION; ENDOTHELIAL FUNCTION
AB Childhood and adolescent overweight and obesity is an important and increasingly prevalent public health problem in Canada and worldwide. High adiposity in youth is indicated in clinical practice by plotting body mass index on appropriate percentile charts normed for age and sex, although waist measures might be a further tool. High adiposity can lead to adiposopathy in youth, with associated increases in inflammation and oxidative stress, changes in adipokines, and endocrinopathy. This is manifest as cardiometabolic risk factors in similar patterns to those in noted in obese adults. Obesity and cardiometabolic risk factors have been shown to be associated with vascular changes indicative of early atherosclerosis, and ventricular hypertrophy, dilation, and dysfunction. These cardiovascular consequences are evident in youth, but childhood obesity is also predictive of similar consequences in adulthood. Childhood obesity and risk factors have been shown to track into adulthood and worsen in most individuals. The result is an exponential acceleration of atherosclerosis, which can be predicted to translate into an epidemic of premature cardiovascular disease and events. A change in paradigm is needed toward preventing and curing atherosclerosis and not just preventing cardiovascular disease. This would necessarily create an imperative for preventing and treating childhood obesity. Urgent attention, policy, and action are needed to avoid the enormous future social and health care costs associated with the cardiovascular consequences of obesity in youth.
C1 [McCrindle, Brian W.] Univ Toronto, Hosp Sick Children, Dept Pediat, Labatt Family Heart Ctr, Toronto, ON M5G 1X8, Canada.
C3 University of Toronto; Hospital for Sick Children (SickKids); Labatt
   Family Heart Centre
RP McCrindle, BW (corresponding author), Hosp Sick Children, 555 Univ Ave, Toronto, ON M5G 1X8, Canada.
EM brian.mccrindle@sickkids.ca
FU CIBC World Markets Endowed Chair in Child Health Research
FX Supported in part by the CIBC World Markets Endowed Chair in Child
   Health Research.
CR Alp H, 2013, CAN J CARDIOL, V29, P1118, DOI 10.1016/j.cjca.2012.07.846
   Anis AH, 2010, OBES REV, V11, P31, DOI 10.1111/j.1467-789X.2009.00579.x
   [Anonymous], 2013, INT PREV MAN CHILDH
   Bays HE, 2011, J AM COLL CARDIOL, V57, P2461, DOI 10.1016/j.jacc.2011.02.038
   Bazzano LA, 2011, CLIN CARDIOL, V34, P153, DOI 10.1002/clc.20896
   Berenson GS, 1998, NEW ENGL J MED, V338, P1650, DOI 10.1056/NEJM199806043382302
   Brumbaugh DE, 2012, J CLIN ENDOCR METAB, V97, pE1099, DOI 10.1210/jc.2011-3243
   Chang Y, 2014, J AM COLL CARDIOL, V63, P2679, DOI 10.1016/j.jacc.2014.03.042
   Cohen M, 2014, OBESITY, V22, P1280, DOI 10.1002/oby.20674
   Copeland KC, 2013, PEDIATRICS, V131, P364, DOI 10.1542/peds.2012-3494
   Cote AT, 2013, J AM COLL CARDIOL, V62, P1309, DOI 10.1016/j.jacc.2013.07.042
   Deshmukh-Taskar P, 2006, EUR J CLIN NUTR, V60, P48, DOI 10.1038/sj.ejcn.1602266
   Di Salvo G, 2006, EUR HEART J, V27, P2689, DOI 10.1093/eurheartj/ehl163
   Dong ML, 2013, J MOL CELL CARDIOL, V55, P111, DOI 10.1016/j.yjmcc.2012.08.023
   Evelein AMV, 2013, J CLIN ENDOCR METAB, V98, P794, DOI 10.1210/jc.2012-3208
   Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents, 2011, Pediatrics, V128 Suppl 5, pS213, DOI 10.1542/peds.2009-2107C
   Farpour-Lambert NJ, 2009, J AM COLL CARDIOL, V54, P2396, DOI 10.1016/j.jacc.2009.08.030
   Freedman DS, 2008, INT J OBESITY, V32, P749, DOI 10.1038/sj.ijo.0803798
   Friedemann C, 2012, BMJ-BRIT MED J, V345, DOI 10.1136/bmj.e4759
   Halbach SM, 2013, CURR HYPERTENS REP, V15, P224, DOI 10.1007/s11906-013-0334-7
   Huang F, 2011, CHILD CARE HLTH DEV, V37, P377, DOI 10.1111/j.1365-2214.2010.01173.x
   Janssen I, 2011, OBES REV, V12, P397, DOI 10.1111/j.1467-789X.2010.00815.x
   Janssen I, 2013, CAN J DIABETES, V37, P90, DOI 10.1016/j.jcjd.2013.02.059
   Janssen I, 2012, OBESITY, V20, P916, DOI 10.1038/oby.2011.122
   Javed A, PEDIAT OBES
   Juonala M, 2010, CIRCULATION, V122, P2514, DOI 10.1161/CIRCULATIONAHA.110.966465
   Kelishadi R, 2008, CLIN CHEM, V54, P147, DOI 10.1373/clinchem.2007.089953
   Kelly AS, 2004, J PEDIATR-US, V145, P731, DOI 10.1016/j.jpeds.2004.08.004
   Kennedy MJ, 2013, PEDIATR DRUGS, V15, P335, DOI 10.1007/s40272-013-0028-2
   Khoury M, 2013, J AM COLL CARDIOL, V62, P742, DOI 10.1016/j.jacc.2013.01.026
   Khoury M, 2012, ARCH PEDIAT ADOL MED, V166, P719, DOI 10.1001/archpediatrics.2012.126
   Koopman LP, 2012, J AM SOC ECHOCARDIOG, V25, P401, DOI 10.1016/j.echo.2011.12.018
   Kramer CK, 2013, ANN INTERN MED, V159, P758, DOI 10.7326/0003-4819-159-11-201312030-00008
   Li SX, 2012, AM J EPIDEMIOL, V176, pS142, DOI 10.1093/aje/kws236
   Lim S, 2014, ARTERIOSCL THROM VAS, V34, P1820, DOI 10.1161/ATVBAHA.114.303035
   Magnussen CG, 2010, CIRCULATION, V122, P1604, DOI 10.1161/CIRCULATIONAHA.110.940809
   Manco M, 2013, ATHEROSCLEROSIS, V226, P490, DOI 10.1016/j.atherosclerosis.2012.11.023
   Maximova K, 2013, CAN J CARDIOL, V29, P976, DOI 10.1016/j.cjca.2012.08.013
   McCrindle BW, 2013, CIRCULATION, V128, P2162, DOI 10.1161/CIRCULATIONAHA.113.002411
   McDonagh MS, 2014, JAMA PEDIATR, V168, P178, DOI 10.1001/jamapediatrics.2013.4200
   McGill HC, 1998, AM J CARDIOL, V82, p30T
   McGill HC, 2002, CIRCULATION, V105, P2712, DOI 10.1161/01.CIR.0000018121.67607.CE
   Meyer AA, 2006, J AM COLL CARDIOL, V48, P1865, DOI 10.1016/j.jacc.2006.07.035
   Montero D, 2012, OBES REV, V13, P441, DOI 10.1111/j.1467-789X.2011.00956.x
   Murphy ECS, 2009, INT J PEDIATR OBES, V4, P205, DOI 10.3109/17477160902846187
   Neovius M, 2005, INT J OBESITY, V29, P163, DOI 10.1038/sj.ijo.0802867
   NEWMAN WP, 1986, NEW ENGL J MED, V314, P138, DOI 10.1056/NEJM198601163140302
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Olza J., 2014, Public Health Nutr, V2, P1
   Oude Luttikhuis H, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001872.pub2
   Owen CG, 2005, PEDIATRICS, V115, P1367, DOI 10.1542/peds.2004-1176
   Park JH, 2012, BMC PEDIATR, V12, DOI 10.1186/1471-2431-12-111
   Poirier P, 2006, CIRCULATION, V113, P898, DOI 10.1161/CIRCULATIONAHA.106.171016
   Potter CM, 2013, J EPIDEMIOL COMMUN H, V67, P1032, DOI 10.1136/jech-2012-201978
   Reilly JJ, 2010, J HUM NUTR DIET, V23, P205, DOI 10.1111/j.1365-277X.2010.01054.x
   Roberts KC, 2012, HEALTH REP, V23, P37
   Robinson JG, 2014, J AM COLL CARDIOL, V63, P2779, DOI 10.1016/j.jacc.2014.04.009
   Segovia SA, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/418975
   Shields M, 2010, INT J PEDIATR OBES, V5, P265, DOI 10.3109/17477160903268282
   Skilton MR, 2014, ATHEROSCLEROSIS, V233, P370, DOI 10.1016/j.atherosclerosis.2014.01.020
   Skilton MR, 2013, PEDIATRICS, V131, pE1821, DOI 10.1542/peds.2012-2789
   Steinberger J, 2009, CIRCULATION, V119, P628, DOI 10.1161/CIRCULATIONAHA.108.191394
   Tapp RJ, 2014, BMC CARDIOVASC DISOR, V14, DOI 10.1186/1471-2261-14-79
   Urbina EM, 2009, HYPERTENSION, V54, P919, DOI 10.1161/HYPERTENSIONAHA.109.192639
   Viner RM, 2010, OBES REV, V11, P593, DOI 10.1111/j.1467-789X.2009.00651.x
   Wang YF, 2008, OBESITY, V16, P2323, DOI 10.1038/oby.2008.351
   Watts K, 2004, J AM COLL CARDIOL, V43, P1823, DOI 10.1016/j.jacc.2004.01.032
   Watts K, 2004, J PEDIATR-US, V144, P620, DOI 10.1016/j.jpeds.2004.02.027
   Whitlock EP, 2010, PEDIATRICS, V125, pE396, DOI 10.1542/peds.2009-1955
   Woo KS, 2004, CIRCULATION, V109, P1981, DOI 10.1161/01.CIR.0000126599.47470.BE
NR 70
TC 106
Z9 130
U1 0
U2 36
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0828-282X
EI 1916-7075
J9 CAN J CARDIOL
JI Can. J. Cardiol.
PD FEB
PY 2015
VL 31
IS 2
DI 10.1016/j.cjca.2014.08.017
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CD1FX
UT WOS:000350821300011
PM 25661547
DA 2025-06-11
ER

PT J
AU Khedr, NF
   Zahran, ES
   Ebeid, AM
   Melek, ST
   Werida, RH
AF Khedr, Naglaa F.
   Zahran, Enas S.
   Ebeid, Abla M.
   Melek, Samuel T.
   Werida, Rehab H.
TI Effect of green coffee on miR-133a, miR-155 and inflammatory biomarkers
   in obese individuals
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Adiponectin; Green coffee; Metabolic syndrome; miR-133a; miR-155;
   Resistin
ID DENSITY-LIPOPROTEIN CHOLESTEROL; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   GLUCOSE; PLASMA; ALPHA; MIRNA; ACID
AB ObjectivesMetabolic syndrome is a cluster of conditions that increases the risk of atherosclerotic cardiovascular diseases. The current study was a randomized, double blind, placebo-controlled study that aimed to determine the impact of green coffee (GC) in obese patients with metabolic syndrome through analysis of miRNA-155, miRNA-133a and the inflammatory biomarkers such as resistin, TNF-alpha, total sialic acid, homocysteine, high sensitivity C-reactive protein (hs-CRP), and the anti-inflammatory cytokine, adiponectin.MethodsOne hundred-sixty obese patients were randomly supplemented either with GC capsules (800 mg) or placebo daily for six months. Both groups were advised to take a balanced diet. Blood samples were collected at baseline and after six months of supplementation.ResultsGC supplementation for 6 months reduced BMI (p = 0.002), waist circumference (p = 0.038), blood glucose (p = 0.002), HbA1c% (p = 0.000), Insulin (p = 0.000), systolic blood pressure (p = 0.005), diastolic BP (p = 0.001) compared with placebo. GC significantly decreased total cholesterol (TC, p = 0.000), LDL-C (p = 0.001), triglycerides (TG, p = 0.002) and increased HDL-C (p = 0.008) compared with placebo group. In addition, GC significantly (p <= 0.005) reduced total sialic acid, homocysteine, resistin, TNF-alpha, hs-CRP and the oxidative stress marker malondialdehyde (MDA), but increased serum adiponectin (p = 0.000) compared to placebo group. There was a significant reduction in the gene expression of miR-133a (p = 0.000) in GC group as compared with baseline levels and with the control placebo group (p = 0.001) after 6 months.ConclusionGC administration modulated metabolic syndrome by decreasing BMI, high BP, blood glucose, dyslipidemia, miRNA-133a and inflammatory biomarkers that constitute risk factors for cardiovascular diseases.ClinicalTrials.gov registration No. is NCT05688917.ConclusionGC administration modulated metabolic syndrome by decreasing BMI, high BP, blood glucose, dyslipidemia, miRNA-133a and inflammatory biomarkers that constitute risk factors for cardiovascular diseases.ClinicalTrials.gov registration No. is NCT05688917.
C1 [Khedr, Naglaa F.] Tanta Univ, Fac Pharm, Biochem Dept, Med Complex, Al Baher St, Tanta 31527, Egypt.
   [Zahran, Enas S.] Menoufia Univ, Fac Med, Internal Med Dept, Shibin Al Kawm, Egypt.
   [Ebeid, Abla M.] AL Delta Univ, Fac Pharm, Clin Pharm Dept, Gamasa, Egypt.
   [Melek, Samuel T.] Natl Org Drug Control & Res NODCAR, Dept Parasitol & Blood Res, Cairo 12654, Egypt.
   [Werida, Rehab H.] Damanhour Univ, Fac Pharm, Clin Pharm Dept, Damanhour, Egypt.
C3 Egyptian Knowledge Bank (EKB); Tanta University; Egyptian Knowledge Bank
   (EKB); Menofia University; Delta University for Science & Technology;
   National Organization for Drug Control & Research (NODCAR); Egyptian
   Knowledge Bank (EKB); Damanhour University
RP Khedr, NF (corresponding author), Tanta Univ, Fac Pharm, Biochem Dept, Med Complex, Al Baher St, Tanta 31527, Egypt.; Werida, RH (corresponding author), Damanhour Univ, Fac Pharm, Clin Pharm Dept, Damanhour, Egypt.
EM naglaa.khedr@pharm.tanta.edu.eg; rehabwrieda@pharm.dmu.edu.eg
RI Werida, Rehab/AAU-2278-2021
OI khedr, naglaa/0000-0003-4539-8940
FU Tanta University; Faculty of Pharmacy, Tanta University
FX The authors thank medical staff members of the Internal Medicine
   Department, Faculty of Medicine, Menoufia University, Egypt, for helping
   in the recruitment of participants. Authors also thank the Faculty of
   Pharmacy, Tanta University and the Faculty of Pharmacy, at Damanhour and
   Delta University for supporting the research.
CR Agbu P, 2021, NAT REV MOL CELL BIO, V22, P425, DOI 10.1038/s41580-021-00354-w
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   ALLAIN CC, 1974, CLIN CHEM, V20, P470
   Asbaghi O, 2020, NUTR J, V19, DOI 10.1186/s12937-020-00587-z
   AUBREELECAT A, 1989, ANAL BIOCHEM, V178, P427, DOI 10.1016/0003-2697(89)90665-9
   BUCOLO G, 1973, CLIN CHEM, V19, P476
   Caro-Gómez E, 2019, NUTRIENTS, V11, DOI 10.3390/nu11030497
   Cerda A, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22031468
   Chakraborty C, 2014, WIRES RNA, V5, P697, DOI 10.1002/wrna.1240
   Chen H, 2020, COMPLEMENT THER MED, V52, DOI 10.1016/j.ctim.2020.102498
   Corp I.B.M., 2023, IBM SPSS Statistics for Windows. Version 29.0.2.0
   Daily ZA, 2023, BMC ORAL HEALTH, V23, DOI 10.1186/s12903-023-03584-w
   de Gonzalo-Calvo D, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-00070-6
   DURRINGTON PN, 1982, CRC CR REV CL LAB SC, V18, P31, DOI 10.3109/10408368209082589
   DWEK RA, 1993, ANNU REV BIOCHEM, V62, P65, DOI 10.1146/annurev.bi.62.070193.000433
   El-Kersh DM, 2023, FOOD CHEM TOXICOL, V179, DOI 10.1016/j.fct.2023.113971
   Ellulu MS, 2017, ARCH MED SCI, V13, P851, DOI 10.5114/aoms.2016.58928
   Engin A, 2017, ADV EXP MED BIOL, V960, P1, DOI 10.1007/978-3-319-48382-5_1
   Fodor A, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22126337
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Grzelczyk J, 2020, J THERM ANAL CALORIM, V142, P877, DOI 10.1007/s10973-020-09801-w
   Heyn GS, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.563816
   Huang JH, 2023, FRONT PHARMACOL, V14, DOI 10.3389/fphar.2023.1218015
   Hwang SJ, 2014, INFLAMM RES, V63, P81, DOI 10.1007/s00011-013-0674-4
   Jeszka-Skowron M, 2016, EUR FOOD RES TECHNOL, V242, P1403, DOI 10.1007/s00217-016-2643-y
   Johnson C, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01297
   Khalili-Moghadam S, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1241844
   Kim H., 2017, FASEB J, V31, P3, DOI [10.1096/fasebj.31.1supplement.46.3, DOI 10.1096/FASEBJ.31.1SUPPLEMENT.46.3]
   Kim NH, 2020, CLIN NUTR, V39, P910, DOI 10.1016/j.clnu.2019.03.033
   Liang N, 2016, NUTRIENTS, V8, DOI 10.3390/nu8010016
   Lukitasari M., 2017, Asian J Pharmaceutical Clin Res, V10, P279, DOI [10.12688/f1000research.55470.1, DOI 10.22159/AJPCR.2017.V10I9.19329, 10.22159/ajpcr.2017.v10i9.19329, DOI 10.2159/AJPCR.2017.V10I9.19329]
   Lukitasari M, 2020, J ADV PHARM TECHNOL, V11, P81, DOI 10.4103/japtr.JAPTR_116_19
   Maitrias P, 2017, ARTERIOSCL THROM VAS, V37, P1608, DOI 10.1161/ATVBAHA.117.309233
   Malo E, 2011, METAB SYNDR RELAT D, V9, P203, DOI 10.1089/met.2010.0106
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Meng SX, 2013, EVID-BASED COMPL ALT, V2013, DOI [10.1155/2013/801457, 10.1155/2013/702196]
   Meuth VML, 2023, OBESITIES-BASEL, V3, P243, DOI 10.3390/obesities3030020
   Morvaridi M, 2020, J DIABETES METAB DIS, V19, P645, DOI 10.1007/s40200-020-00536-x
   Nikpayam O, 2019, DIABETOL METAB SYNDR, V11, DOI 10.1186/s13098-019-0489-8
   Ochiai R, 2004, HYPERTENS RES, V27, P731, DOI 10.1291/hypres.27.731
   Ohishi T, 2021, MOLECULES, V26, DOI 10.3390/molecules26020453
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   Panyathep A, 2023, FOODS, V12, DOI 10.3390/foods12142648
   Patel H, 2015, CURR RES NUTR FOOD S, V3, P263, DOI 10.12944/CRNFSJ.3.3.10
   Qureshi R, 2013, BMC MED GENOMICS, V6, DOI 10.1186/1755-8794-6-S1-S14
   Rakhshandehroo M, 2010, PPAR RES, V2010, DOI 10.1155/2010/612089
   Rohman MS, 2023, BENI-SUEF U J BASIC, V12, DOI 10.1186/s43088-023-00381-w
   Roshan H, 2018, BRIT J NUTR, V119, P250, DOI 10.1017/S0007114517003439
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Salamat S, 2019, EUR J INTEGR MED, V28, P109, DOI 10.1016/j.eujim.2019.05.001
   Sánchez-Margalet V, 2002, J NUTR BIOCHEM, V13, P75, DOI 10.1016/S0955-2863(01)00197-8
   Seliem EM, 2022, LIFE-BASEL, V12, DOI 10.3390/life12050693
   Shokouh P, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092074
   Sudeep HV, 2021, SAGE OPEN MED, V9, DOI 10.1177/20503121211002590
   Summerhill VI, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20143561
   Sun L, 2015, MOL MED REP, V11, P4039, DOI 10.3892/mmr.2015.3246
   Tzanavari T, 2010, CURR DIR AUTOIMMUN, V11, P145, DOI 10.1159/000289203
   Verma N, 2024, J AM NUTR ASSOC, V43, P315, DOI 10.1080/27697061.2023.2284994
   Wang L, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.943911
   WHO, 2003, WHO TECH REP SER, V916, P1
   Yang XM, 2022, BMC WOMENS HEALTH, V22, DOI 10.1186/s12905-022-01994-6
   Yung JHM, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9030706
   Zhang C, 2019, LIPIDS HEALTH DIS, V18, DOI 10.1186/s12944-019-1113-5
   Zhou Y, 2022, CARDIOL J, V29, P284, DOI 10.5603/CJ.a2020.0034
NR 64
TC 0
Z9 0
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD OCT 28
PY 2024
VL 16
IS 1
AR 256
DI 10.1186/s13098-024-01478-7
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA K5R4N
UT WOS:001344442100001
PM 39468643
OA Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Martins, AC
   Ferrer, B
   Tinkov, AA
   Caito, S
   Deza-Ponzio, R
   Skalny, AV
   Bowman, AB
   Aschner, M
AF Martins, Airton C.
   Ferrer, Beatriz
   Tinkov, Alexey A.
   Caito, Samuel
   Deza-Ponzio, Romina
   Skalny, Anatoly V.
   Bowman, Aaron B.
   Aschner, Michael
TI Association between Heavy Metals, Metalloids and Metabolic Syndrome: New
   Insights and Approaches
SO TOXICS
LA English
DT Review
DE arsenic; cadmium; diabetes; hypertension; lead; mercury; obesity
ID WHITE ADIPOSE-TISSUE; ARSENIC EXPOSURE; CADMIUM EXPOSURE; OXIDATIVE
   STRESS; NATIONAL-HEALTH; URINARY CADMIUM; METHYL MERCURY; BODY-WEIGHT;
   INSULIN-SECRETION; ENDOTHELIAL-CELLS
AB Metabolic syndrome (MetS) is an important public health issue that affects millions of people around the world and is growing to pandemic-like proportions. This syndrome is defined by the World Health Organization (WHO) as a pathologic condition characterized by abdominal obesity, insulin resistance, hypertension, and hyperlipidemia. Moreover, the etiology of MetS is multifactorial, involving many environmental factors, including toxicant exposures. Several studies have associated MetS with heavy metals exposure, which is the focus of this review. Environmental and/or occupational exposure to heavy metals are a major risk, contributing to the development of chronic diseases. Of particular note, toxic metals such as mercury, lead, and cadmium may contribute to the development of MetS by altering oxidative stress, IL-6 signaling, apoptosis, altered lipoprotein metabolism, fluid shear stress and atherosclerosis, and other mechanisms. In this review, we discuss the known and potential roles of heavy metals in MetS etiology as well as potential targeted pathways that are associated with MetS. Furthermore, we describe how new approaches involving proteomic and transcriptome analysis, as well as bioinformatic tools, may help bring about an understanding of the involvement of heavy metals and metalloids in MetS.
C1 [Martins, Airton C.; Ferrer, Beatriz; Deza-Ponzio, Romina; Aschner, Michael] Albert Einstein Coll Med, Dept Mol Pharmacol, New York, NY 10461 USA.
   [Tinkov, Alexey A.; Skalny, Anatoly V.] Yaroslavl State Univ, Lab Ecobiomonitoring & Qual Control, Yaroslavl 150003, Russia.
   [Tinkov, Alexey A.; Skalny, Anatoly V.] Sechenov Univ, IM Sechenov First Moscow State Med Univ, Moscow 119435, Russia.
   [Caito, Samuel] Husson Univ, Sch Pharm, Bangor, ME 04401 USA.
   [Bowman, Aaron B.] Purdue Univ, Sch Hlth Sci, W Lafayette, IN 47907 USA.
C3 Yeshiva University; Yaroslavl State University; Sechenov First Moscow
   State Medical University; Husson University; Purdue University System;
   Purdue University
RP Aschner, M (corresponding author), Albert Einstein Coll Med, Dept Mol Pharmacol, New York, NY 10461 USA.
EM airton.dacunhamartinsjunior@einsteinmed.edu; tinkov.a.a@gmail.com;
   bowma117@purdue.edu; michael.aschner@einsteinmed.edu
RI Skalny, Anatoly/J-3953-2019; Tinkov, Alexey/H-5842-2016; Aschner,
   Michael/ACO-6461-2022; C. Martins, Airton/I-8463-2017
OI C. Martins, Airton/0000-0002-2157-5984; aschner,
   michael/0000-0002-2619-1656; Bowman, Aaron/0000-0001-8728-3346; Deza
   Ponzio, Romina/0000-0002-4591-168X
FU Russian Ministry of Science and Higher Education [FENZ-2023-0004];
   National Institute of Environmental Health (NIEHS) [R01ES10563,
   R01ES07331]
FX A.A.T. and A.V.S. were supported by the Russian Ministry of Science and
   Higher Education, Project No. FENZ-2023-0004. MA and ABB were supported
   in part by grants from the National Institute of Environmental Health
   (NIEHS) R01ES10563 and R01ES07331.
CR Abuawad A, 2021, ENVIRON INT, V149, DOI 10.1016/j.envint.2021.106401
   Afolabi OK, 2012, EXCLI J, V11, P677
   Aja PM, 2020, LIFE SCI, V259, DOI 10.1016/j.lfs.2020.118268
   Al-Naemi HA, 2020, ENVIRON SCI POLLUT R, V27, P16246, DOI 10.1007/s11356-020-08116-5
   Alam RTM, 2021, ENVIRON SCI POLLUT R, V28, P31391, DOI 10.1007/s11356-021-13014-5
   Amiri A, 2021, HELIYON, V7, DOI 10.1016/j.heliyon.2021.e06409
   Angeli JK, 2013, FREE RADICAL BIO MED, V65, P838, DOI 10.1016/j.freeradbiomed.2013.08.167
   Aramjoo H, 2022, ENVIRON SCI POLLUT R, V29, P35682, DOI 10.1007/s11356-021-17777-9
   Attia SM, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.1010817
   Attia SM, 2022, EXPOS HEALTH, V14, P171, DOI 10.1007/s12403-021-00427-3
   Ayoub N, 2021, BIOL TRACE ELEM RES, V199, P3625, DOI 10.1007/s12011-020-02502-3
   Ba Q, 2017, ENVIRON HEALTH PERSP, V125, P437, DOI 10.1289/EHP360
   Bae J, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-50965-9
   Balarastaghi S, 2022, BIOMED PHARMACOTHER, V151, DOI 10.1016/j.biopha.2022.113135
   Barnes DM, 2003, TOXICOL SCI, V75, P368, DOI 10.1093/toxsci/kfg195
   Barregard L, 2021, ENVIRON HEALTH PERSP, V129, DOI 10.1289/EHP8523
   Beck R, 2019, ARCH TOXICOL, V93, P3099, DOI 10.1007/s00204-019-02574-8
   Beezhold K, 2017, TOXICOL LETT, V265, P147, DOI 10.1016/j.toxlet.2016.12.002
   BERTHOUD HR, 1976, TOXICOL APPL PHARM, V36, P19, DOI 10.1016/0041-008X(76)90023-5
   Betanzos-Robledo L, 2022, NEW DIR CHILD ADOLES, V2022, P37, DOI 10.1002/cad.20463
   Block JP, 2009, AM J EPIDEMIOL, V170, P181, DOI 10.1093/aje/kwp104
   Brockman JD, 2011, BIOL TRACE ELEM RES, V144, P812, DOI 10.1007/s12011-011-9019-8
   Buha A, 2020, TOXICS, V8, DOI 10.3390/toxics8030063
   Bulka CM, 2019, ENVIRON RES, V168, P397, DOI 10.1016/j.envres.2018.10.022
   Bulka CM, 2017, ENVIRON HEALTH PERSP, V125, DOI 10.1289/EHP1202
   Caciari T, 2013, INT J OCCUP MED ENV, V26, P440, DOI 10.2478/s13382-013-0111-5
   Caglayan C, 2019, J FOOD BIOCHEM, V43, DOI 10.1111/jfbc.12720
   Caito Samuel, 2017, Adv Neurobiol, V18, P3, DOI 10.1007/978-3-319-60189-2_1
   Caito SW, 2020, TOXICOL SCI, V174, P112, DOI 10.1093/toxsci/kfz244
   Caito SW, 2018, TOXICOL SCI, V161, P443, DOI 10.1093/toxsci/kfx226
   Calderón-DuPont D, 2023, TOXICOL APPL PHARM, V468, DOI 10.1016/j.taap.2023.116428
   Castriota F, 2020, AM J PHYSIOL-ENDOC M, V318, pE667, DOI 10.1152/ajpendo.00282.2019
   Castriota F, 2020, ENVIRON HEALTH PERSP, V128, DOI 10.1289/EHP4517
   Castriota F, 2018, ENVIRON RES, V167, P248, DOI 10.1016/j.envres.2018.07.022
   Ceja-Galicia ZA, 2017, MOL CELL ENDOCRINOL, V452, P25, DOI 10.1016/j.mce.2017.05.008
   Chauhan S, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20112755
   Chen JW, 2012, CHEMOSPHERE, V88, P432, DOI 10.1016/j.chemosphere.2012.02.059
   Chen SM, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00772
   Chen YW, 2006, CHEM RES TOXICOL, V19, P1080, DOI 10.1021/tx0600705
   Chen Y, 2019, ENVIRON RES, V178, DOI 10.1016/j.envres.2019.108681
   Cheng J, 2021, J TRACE ELEM MED BIO, V67, DOI 10.1016/j.jtemb.2021.126778
   Chi L, 2019, ENVIRON HEALTH PERSP, V127, DOI 10.1289/EHP4415
   Cho HW, 2020, SCI TOTAL ENVIRON, V709, DOI 10.1016/j.scitotenv.2019.135965
   Cho KY, 2021, CHILDREN-BASEL, V8, DOI 10.3390/children8121087
   Cifuentes F, 2009, INT J TOXICOL, V28, P534, DOI 10.1177/1091581809345924
   Clarkson TW, 2006, CRIT REV TOXICOL, V36, P609, DOI 10.1080/10408440600845619
   Crawford N, 2021, TOXICS, V9, DOI 10.3390/toxics9110287
   da Costa CS, 2021, ENVIRON POLLUT, V269, DOI 10.1016/j.envpol.2020.116154
   Dias LKM, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000028162
   Donnelly JE, 2009, MED SCI SPORT EXER, V41, P459, DOI 10.1249/MSS.0b013e3181949333
   dos Santos AA, 2016, J TRACE ELEM MED BIO, V38, P99, DOI 10.1016/j.jtemb.2016.03.001
   Douillet C, 2017, ARCH TOXICOL, V91, P2617, DOI 10.1007/s00204-016-1890-9
   Dover EN, 2018, ARCH TOXICOL, V92, P693, DOI 10.1007/s00204-017-2074-y
   DUBUC PU, 1973, PHYSIOL BEHAV, V10, P677, DOI 10.1016/0031-9384(73)90143-1
   Duc HN, 2022, BIOL TRACE ELEM RES, V200, P3554, DOI 10.1007/s12011-021-02972-z
   Duc HN, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10050808
   DUTTA HM, 1986, B ENVIRON CONTAM TOX, V36, P181, DOI 10.1007/BF01623492
   Echeverría R, 2019, SCI TOTAL ENVIRON, V670, P1028, DOI 10.1016/j.scitotenv.2019.03.114
   Edwards JR, 2009, TOXICOL APPL PHARM, V238, P289, DOI 10.1016/j.taap.2009.03.007
   Eick SM, 2020, CURR ENV HLTH REP, V7, P343, DOI 10.1007/s40572-020-00288-z
   Eick SM, 2019, ENVIRON RES, V172, P578, DOI 10.1016/j.envres.2019.03.013
   Sarmiento-Ortega VE, 2023, BIOL TRACE ELEM RES, V201, P3903, DOI 10.1007/s12011-022-03471-5
   Fagerberg B, 2021, J INTERN MED, V290, P1153, DOI 10.1111/joim.13350
   Fan Y, 2017, NUTRIENTS, V9, DOI 10.3390/nu9020104
   Farkhondeh T, 2019, J CELL PHYSIOL, V234, P12516, DOI 10.1002/jcp.28112
   Farzan SF, 2017, ENVIRON HEALTH PERSP, V125, DOI [10.1289/EHP2062, 10.1289/ehp2062]
   Ferrer B, 2021, FOOD CHEM TOXICOL, V147, DOI 10.1016/j.fct.2020.111924
   Ferrer B, 2018, TOXICOL SCI, V163, P557, DOI 10.1093/toxsci/kfy052
   Filippini T, 2022, ENVIRON INT, V158, DOI 10.1016/j.envint.2021.106920
   Fitzgerald R, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22010360
   Gao YF, 2018, ONCOTARGET, V9, P4915, DOI 10.18632/oncotarget.23518
   Gao Y, 2018, TOXICOL APPL PHARM, V353, P15, DOI 10.1016/j.taap.2018.05.032
   Gasser M, 2022, TOXICOLOGY, V470, DOI 10.1016/j.tox.2022.153153
   Ghaedrahmat Z, 2021, J TRACE ELEM MED BIO, V66, DOI 10.1016/j.jtemb.2021.126757
   Gong YY, 2021, ADV SCI, V8, DOI 10.1002/advs.202002715
   Goodarzi MO, 2018, LANCET DIABETES ENDO, V6, P223, DOI 10.1016/S2213-8587(17)30200-0
   Grau-Perez M, 2022, ARTERIOSCL THROM VAS, V42, P87, DOI 10.1161/ATVBAHA.121.316358
   Grau-Perez M, 2018, ENVIRON POLLUT, V235, P948, DOI 10.1016/j.envpol.2018.01.008
   Grau-Perez M, 2017, ENVIRON HEALTH PERSP, V125, DOI [10.1289/EHP2566, 10.1289/ehp2566]
   Green AJ, 2018, INT J OBESITY, V42, P1285, DOI 10.1038/s41366-018-0036-y
   Guaraldi G, 2017, AIDS, V31, pS147, DOI [10.1097/QAD.0000000000001483, 10.1097/qad.0000000000001483]
   Guo FF, 2019, ENVIRON SCI POLLUT R, V26, P19272, DOI 10.1007/s11356-019-04943-3
   Guo L, 2015, J BIOL CHEM, V290, P755, DOI 10.1074/jbc.R114.619957
   Hales Craig M, 2020, NCHS Data Brief, P1, DOI 10.21608/seaf.2020.162168
   Han SJ, 2015, INT J ENV RES PUB HE, V12, P11396, DOI 10.3390/ijerph120911396
   Hanna-Attisha M, 2016, AM J PUBLIC HEALTH, V106, P283, DOI 10.2105/AJPH.2015.303003
   Hong HH, 2022, SCI TOTAL ENVIRON, V849, DOI 10.1016/j.scitotenv.2022.157819
   Hong HH, 2022, J TRACE ELEM MED BIO, V71, DOI 10.1016/j.jtemb.2022.126952
   Hong HH, 2022, ENVIRON INT, V161, DOI 10.1016/j.envint.2022.107139
   Hou H, 2017, ENVIRON SCI POLLUT R, V24, P10621, DOI 10.1007/s11356-017-8743-9
   Hou YY, 2013, ENVIRON HEALTH PERSP, V121, P237, DOI 10.1289/ehp.1205731
   Huang CC, 2019, TOXICOLOGY, V425, DOI 10.1016/j.tox.2019.152252
   Huang M, 2019, ARCH TOXICOL, V93, P2525, DOI 10.1007/s00204-019-02526-2
   Huang WY, 2022, INT J OBESITY, V46, P1435, DOI 10.1038/s41366-022-01127-x
   Iacomino G, 2017, GENES NUTR, V12, DOI 10.1186/s12263-017-0577-z
   Ibáñez-Ventoso C, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002818
   Jacquet A, 2019, CHEMOSPHERE, V219, P109, DOI 10.1016/j.chemosphere.2018.11.137
   Jeon J, 2021, J TRACE ELEM MED BIO, V64, DOI 10.1016/j.jtemb.2020.126678
   Jia P, 2021, OBES REV, V22, DOI 10.1111/obr.13158
   Jia X, 2020, J HAZARD MATER, V399, DOI 10.1016/j.jhazmat.2020.123034
   Jiang F, 2018, ENDOCRINE, V61, P258, DOI 10.1007/s12020-018-1623-3
   Jyoti U, 2016, N-S ARCH PHARMACOL, V389, P167, DOI 10.1007/s00210-015-1184-4
   Karatela S, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16122238
   Kaufman JA, 2021, ENVIRON RES, V195, DOI 10.1016/j.envres.2021.110864
   Kawakami T, 2012, TOXICOL APPL PHARM, V258, P32, DOI 10.1016/j.taap.2011.10.004
   Kawakami T, 2010, TOXICOLOGY, V267, P20, DOI 10.1016/j.tox.2009.07.022
   Kazemifar Amir Mohammad, 2020, Environ Anal Health Toxicol, V35, pe2020006, DOI 10.5620/eaht.e2020006
   Khan F, 2020, ECOTOX ENVIRON SAFE, V201, DOI 10.1016/j.ecoenv.2020.110802
   Khan F, 2017, FOOD CHEM TOXICOL, V107, P406, DOI 10.1016/j.fct.2017.07.021
   Kijani S, 2017, ATHEROSCLEROSIS, V263, pE1, DOI 10.1016/j.atherosclerosis.2017.06.034
   Kim DW, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19063181
   Kirkley AG, 2018, AM J PHYSIOL-REG I, V314, pR294, DOI 10.1152/ajpregu.00522.2016
   Knani L, 2019, J PINEAL RES, V67, DOI 10.1111/jpi.12597
   Kukongviriyapan U, 2014, NUTRIENTS, V6, P1194, DOI 10.3390/nu6031194
   Kumar WM, 2019, FASEB J, V33
   Leocádio PCL, 2020, ECOTOX ENVIRON SAFE, V204, DOI 10.1016/j.ecoenv.2020.111036
   Landrigan PJ, 2005, ENVIRON HEALTH PERSP, V113, P1230, DOI 10.1289/ehp.7571
   Leasure JL, 2008, ENVIRON HEALTH PERSP, V116, P355, DOI 10.1289/ehp.10862
   Lee EJ, 2012, DRUG CHEM TOXICOL, V35, P225, DOI 10.3109/01480545.2011.591401
   Lee K, 2018, INT ARCH OCC ENV HEA, V91, P185, DOI 10.1007/s00420-017-1269-0
   Lee MY, 2003, ENVIRON HEALTH PERSP, V111, P513, DOI 10.1289/ehp.5916
   Lee S, 2020, TOXICS, V8, DOI 10.3390/toxics8030047
   Leung AKC, 2024, CURR PEDIATR REV, V20, P2, DOI 10.2174/1573396318666220801093225
   Li FJ, 2022, CHEMOSPHERE, V308, DOI 10.1016/j.chemosphere.2022.136396
   Li TZ, 2022, NUTRIENTS, V14, DOI 10.3390/nu14194038
   Li WQ, 2021, ECOTOX ENVIRON SAFE, V215, DOI 10.1016/j.ecoenv.2021.112130
   Li XR, 2022, EXP THER MED, V23, DOI 10.3892/etm.2022.11282
   Li YY, 2020, ARCH TOXICOL, V94, P1955, DOI 10.1007/s00204-020-02729-y
   Li YJ, 2017, ENVIRON SCI POLLUT R, V24, P10083, DOI 10.1007/s11356-017-8610-8
   Liang H, 2021, J APPL TOXICOL, V41, P775, DOI 10.1002/jat.4115
   Liang XP, 2021, EUR HEART J, V42, P2420
   Lu LP, 2023, J EXPO SCI ENV EPID, V33, P846, DOI 10.1038/s41370-022-00444-7
   Luo HG, 2021, ENVIRON POLLUT, V290, DOI 10.1016/j.envpol.2021.118043
   Luo TY, 2022, LIPIDS HEALTH DIS, V21, DOI 10.1186/s12944-022-01743-6
   Ma YQ, 2017, CHEMOSPHERE, V167, P454, DOI 10.1016/j.chemosphere.2016.10.025
   MAGOS L, 1982, NEUROBEH TOXICOL TER, V4, P643
   Mao Q, 2023, CHEMOSPHERE, V313, DOI 10.1016/j.chemosphere.2022.137441
   Maqbool F, 2016, FOOD CHEM TOXICOL, V93, P119, DOI 10.1016/j.fct.2016.05.005
   Martins AC, 2021, CURR OPIN TOXICOL, V25, P30, DOI 10.1016/j.cotox.2021.03.002
   Martins AC, 2021, CURR HYPERTENS REV, V17, P14, DOI 10.2174/1573402117666210121102405
   Martins AD, 2018, J TOXICOL ENV HEAL B, V21, P61, DOI 10.1080/10937404.2018.1432025
   Martins AD, 2015, J TOXICOL ENV HEAL A, V78, P1073, DOI 10.1080/15287394.2015.1055527
   Mondal V, 2020, ENVIRON INT, V143, DOI 10.1016/j.envint.2020.105890
   Moon MK, 2022, ENVIRON RES, V204, DOI 10.1016/j.envres.2021.111888
   Moon SS, 2017, DIABETES METAB J, V41, P96, DOI 10.4093/dmj.2017.41.2.96
   Mostafalou S, 2015, ENVIRON TOXICOL PHAR, V39, P16, DOI 10.1016/j.etap.2014.11.001
   Moynihan M, 2019, FRONT PUBLIC HEALTH, V7, DOI 10.3389/fpubh.2019.00061
   Nakano T, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22020739
   Nascimento TS, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms232213837
   National Institutes of Health, 2022, National Heart, Lung, and Blood Institute
   Nguyen J, 2022, TOXICS, V10, DOI 10.3390/toxics10030107
   Nie XM, 2016, ENVIRON SCI POLLUT R, V23, P18714, DOI 10.1007/s11356-016-7078-2
   Nielsen T, 2022, CHEM RES TOXICOL, V35, P77, DOI 10.1021/acs.chemrestox.1c00306
   Noor N, 2018, ENVIRON INT, V121, P349, DOI 10.1016/j.envint.2018.08.029
   Oken E, 2008, AM J EPIDEMIOL, V167, P1171, DOI 10.1093/aje/kwn034
   Oliveira TF, 2019, BIOL TRACE ELEM RES, V187, P163, DOI 10.1007/s12011-018-1359-1
   Oliver-Williams C, 2018, J AM SOC HYPERTENS, V12, P426, DOI 10.1016/j.jash.2018.03.002
   Osorio-Yáñez C, 2017, TOXICOL IN VITRO, V42, P281, DOI 10.1016/j.tiv.2017.05.008
   Panico P, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.878280
   Park K, 2016, NUTRIENTS, V8, DOI 10.3390/nu8070424
   Park SS, 2017, EPIGENOMICS-UK, V9, P57, DOI 10.2217/epi-2016-0047
   Park YJ, 2019, PUBLIC HEALTH NURS, V36, P118, DOI 10.1111/phn.12548
   Pei P, 2019, FOOD CHEM TOXICOL, V125, P392, DOI 10.1016/j.fct.2019.01.015
   Peña-Fernández A, 2014, ENVIRON INT, V72, P176, DOI 10.1016/j.envint.2014.04.007
   Almenara CCP, 2020, CURR PHARM DESIGN, V26, P3667, DOI 10.2174/1381612826666200415172338
   Díaz MFFP, 2019, J TRACE ELEM MED BIO, V52, P239, DOI 10.1016/j.jtemb.2019.01.007
   Pinheiro JEG, 2020, TOXICOL LETT, V333, P80, DOI 10.1016/j.toxlet.2020.07.027
   Qiu TM, 2023, CELL BIOL TOXICOL, V39, P2165, DOI 10.1007/s10565-022-09703-7
   Qu C, 2022, NUTRIENTS, V14, DOI 10.3390/nu14193993
   Rahaman MS, 2023, CHEMOSPHERE, V318, DOI 10.1016/j.chemosphere.2023.137911
   Ramdas M, 2018, J TRACE ELEM MED BIO, V50, P263, DOI 10.1016/j.jtemb.2018.07.006
   Rehman K, 2018, J CELL BIOCHEM, V119, P157, DOI 10.1002/jcb.26234
   Renu K, 2018, TOXICOL LETT, V284, P86, DOI 10.1016/j.toxlet.2017.11.032
   Rizzetti DA, 2019, TOXICOLOGY, V418, P41, DOI 10.1016/j.tox.2019.02.013
   Rolls Barbara J., 2003, Nutr Today, V38, P42, DOI 10.1097/00017285-200303000-00004
   Rotter I, 2015, INT J ENV RES PUB HE, V12, P3944, DOI 10.3390/ijerph120403944
   Sakamoto M, 2004, DEV BRAIN RES, V152, P171, DOI 10.1016/j.devbrainres.2004.06.016
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Salcedo-Bellido I, 2021, SCI TOTAL ENVIRON, V780, DOI 10.1016/j.scitotenv.2021.146359
   Sanborn MD, 2002, CAN MED ASSOC J, V166, P1287
   Sarath TS, 2014, TOXICOL APPL PHARM, V280, P443, DOI 10.1016/j.taap.2014.08.032
   Sarker MK, 2022, EXPOS HEALTH, V14, P595, DOI 10.1007/s12403-021-00437-1
   SCHROEDER HA, 1975, J NUTR, V105, P452, DOI 10.1093/jn/105.4.452
   Scinicariello F, 2013, TOXICOL APPL PHARM, V273, P516, DOI 10.1016/j.taap.2013.09.022
   Shao WT, 2017, ENVIRON SCI POLLUT R, V24, P11573, DOI 10.1007/s11356-017-8803-1
   Shin Yi-Yeon, 2018, Korean J Pediatr, V61, P121, DOI 10.3345/kjp.2018.61.4.121
   Silva JL, 2021, TOXICOL RES-GER, V37, P311, DOI 10.1007/s43188-020-00066-x
   Silva LFN, 2017, ENVIRON HEALTH PERSP, V125, DOI [10.1289/EHP806, 10.1289/ehp806]
   Singh DP, 2023, MOL BIOL REP, V50, P1033, DOI 10.1007/s11033-022-07992-z
   Skalny AV, 2021, BIOL TRACE ELEM RES, V199, P2874, DOI 10.1007/s12011-020-02430-2
   Smith AR, 2023, EPIDEMIOLOGY, V34, P80, DOI 10.1097/EDE.0000000000001560
   Song Y, 2019, TOXICOLOGY, V424, DOI 10.1016/j.tox.2019.05.012
   Spratlen MJ, 2018, AM J EPIDEMIOL, V187, P1598, DOI 10.1093/aje/kwy048
   Srisuporn P, 2023, INT J HYG ENVIR HEAL, V250, DOI 10.1016/j.ijheh.2023.114124
   Stahr S, 2021, EXPOS HEALTH, V13, P269, DOI 10.1007/s12403-020-00381-6
   Su CT, 2012, SCI TOTAL ENVIRON, V414, P152, DOI 10.1016/j.scitotenv.2011.10.023
   Sun Q, 2019, TOXICOL SCI, V167, P116, DOI 10.1093/toxsci/kfy150
   Sung TC, 2015, BIOMED RES INT-UK, V2015, DOI 10.1155/2015/368087
   Taheri S, 2004, PLOS MED, V1, P210, DOI 10.1371/journal.pmed.0010062
   Takanezawa Y, 2023, TOXICOLOGY, V486, DOI 10.1016/j.tox.2023.153446
   Tang L, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-13694-5
   Tinant G, 2021, CHEMOSPHERE, V263, DOI 10.1016/j.chemosphere.2020.127917
   Tinkov Alexey A, 2021, Fac Rev, V10, P32, DOI 10.12703/r/10-32
   Tinkov AA, 2018, ENVIRON RES, V162, P240, DOI 10.1016/j.envres.2018.01.008
   Tinkov AA, 2017, SCI TOTAL ENVIRON, V601, P741, DOI 10.1016/j.scitotenv.2017.05.224
   Tripathi D, 2020, FEBS J, V287, P3141, DOI 10.1111/febs.15322
   Tsai TL, 2019, ENVIRON INT, V126, P260, DOI 10.1016/j.envint.2019.02.038
   Tyrrell JB, 2017, J TRACE ELEM MED BIO, V39, P221, DOI 10.1016/j.jtemb.2016.10.007
   Vallée A, 2020, ENVIRON SCI POLLUT R, V27, P10748, DOI 10.1007/s11356-019-07249-6
   Virgolini Miriam B, 2021, Adv Neurotoxicol, V5, P159, DOI 10.1016/bs.ant.2020.11.002
   Waghe P, 2017, BIOL TRACE ELEM RES, V176, P350, DOI 10.1007/s12011-016-0851-8
   Waghe P, 2015, CHEM-BIOL INTERACT, V237, P104, DOI 10.1016/j.cbi.2015.06.014
   Wan Y, 2023, FOOD CHEM TOXICOL, V173, DOI 10.1016/j.fct.2023.113603
   Wang GY, 2019, BMC MED, V17, DOI 10.1186/s12916-019-1442-2
   Wang NA, 2022, FOOD CHEM TOXICOL, V170, DOI 10.1016/j.fct.2022.113451
   Wang Q, 2018, SCI TOTAL ENVIRON, V643, P270, DOI 10.1016/j.scitotenv.2018.06.105
   Wang SL, 2007, ENVIRON INT, V33, P805, DOI 10.1016/j.envint.2007.03.004
   Wang X, 2018, TOXICOL LETT, V290, P46, DOI 10.1016/j.toxlet.2018.03.020
   Wang X, 2022, ENVIRON RES, V210, DOI 10.1016/j.envres.2022.112976
   Wang X, 2018, ENVIRON INT, V121, P683, DOI 10.1016/j.envint.2018.09.035
   Warwick M, 2021, J TRACE ELEM MED BIO, V67, DOI 10.1016/j.jtemb.2021.126771
   Wauson EM, 2002, TOXICOL SCI, V65, P211, DOI 10.1093/toxsci/65.2.211
   Wei S, 2020, J HAZARD MATER, V384, DOI 10.1016/j.jhazmat.2019.121390
   Weiden PJ, 2004, SCHIZOPHR RES, V66, P51, DOI 10.1016/S0920-9964(02)00498-X
   Wisessaowapak C, 2021, TOXICOL LETT, V349, P40, DOI 10.1016/j.toxlet.2021.06.002
   Wong WPS, 2021, TOXICOL APPL PHARM, V433, DOI 10.1016/j.taap.2021.115756
   Wu CB, 2022, ENVIRON TOXICOL PHAR, V96, DOI 10.1016/j.etap.2022.103981
   Wu H, 2021, TOXICOLOGY, V457, DOI 10.1016/j.tox.2021.152790
   Wu M, 2017, ONCOTARGET, V8, P113129, DOI 10.18632/oncotarget.21991
   Wu W, 2018, FOOD CHEM TOXICOL, V111, P19, DOI 10.1016/j.fct.2017.10.043
   Xiao LL, 2021, ENVIRON RES, V192, DOI 10.1016/j.envres.2020.110259
   Xiao LL, 2019, ENVIRON POLLUT, V255, DOI 10.1016/j.envpol.2019.113341
   Xu HD, 2021, J TRACE ELEM MED BIO, V63, DOI 10.1016/j.jtemb.2020.126651
   Xu LQ, 2021, ECOTOX ENVIRON SAFE, V223, DOI 10.1016/j.ecoenv.2021.112572
   Xu LQ, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17072536
   Xu YJ, 2022, ENDOCR J, V69, P361, DOI 10.1507/endocrj.EJ21-0115
   Yadav S, 2013, TOXICOL IN VITRO, V27, P211, DOI 10.1016/j.tiv.2012.10.012
   Yamamoto M, 2019, J APPL TOXICOL, V39, P221, DOI 10.1002/jat.3710
   Yamamoto M, 2014, J APPL TOXICOL, V34, P914, DOI 10.1002/jat.2954
   Yang CY, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23052858
   Yang HT, 2007, FOOD CHEM TOXICOL, V45, P2479, DOI 10.1016/j.fct.2007.05.024
   Yang JS, 2021, ECOTOX ENVIRON SAFE, V222, DOI 10.1016/j.ecoenv.2021.112501
   Yang L, 2019, INT J BIOCHEM CELL B, V112, P50, DOI 10.1016/j.biocel.2019.05.001
   Yi SJ, 2021, SCI TOTAL ENVIRON, V777, DOI 10.1016/j.scitotenv.2021.146006
   You Chang-Hun, 2011, J Prev Med Public Health, V44, P218, DOI 10.3961/jpmph.2011.44.5.218
   Yu YX, 2017, SCI TOTAL ENVIRON, V580, P69, DOI 10.1016/j.scitotenv.2016.11.204
   Zareba G, 2008, J APPL TOXICOL, V28, P535, DOI 10.1002/jat.1307
   Zhang CB, 2017, ARCH TOXICOL, V91, P3811, DOI 10.1007/s00204-017-2076-9
   Zhang JX, 2022, ECOTOX ENVIRON SAFE, V244, DOI 10.1016/j.ecoenv.2022.114057
   Zhang JY, 2021, ECOTOX ENVIRON SAFE, V223, DOI 10.1016/j.ecoenv.2021.112590
   Zhang YQ, 2019, ENVIRON INT, V123, P325, DOI 10.1016/j.envint.2018.11.076
   Zhao JX, 2021, ENVIRON POLLUT, V289, DOI 10.1016/j.envpol.2021.117914
   Zhao YN, 2021, TOXICOL MECH METHOD, V31, P188, DOI 10.1080/15376516.2020.1864537
   Zhong QA, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18091905
   Zhou JL, 2022, CHEMOSPHERE, V291, DOI 10.1016/j.chemosphere.2021.132953
   Zhou ML, 2022, ECOTOX ENVIRON SAFE, V231, DOI 10.1016/j.ecoenv.2022.113218
   Zhu YH, 2022, FOOD CHEM TOXICOL, V160, DOI 10.1016/j.fct.2021.112771
   Zuo Z, 2019, SCI TOTAL ENVIRON, V668, P310, DOI 10.1016/j.scitotenv.2019.03.008
NR 258
TC 15
Z9 15
U1 2
U2 16
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2305-6304
J9 TOXICS
JI Toxics
PD AUG
PY 2023
VL 11
IS 8
AR 670
DI 10.3390/toxics11080670
PG 29
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA Q4FI6
UT WOS:001057088400001
PM 37624175
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wu, XY
   Liang, DJ
   Sun, JF
   Lin, YY
   Wu, SJ
AF Wu, Xiaoyun
   Liang, Dongjie
   Sun, Junfang
   Lin, Yanyan
   Wu, Shengjie
TI Association Between Sex-Specific Serum Gamma-Glutamyltransferase and
   Incidence of Hypertension in a Chinese Population Without Metabolic
   Syndrome: A Prospective Observational Study
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Article
DE gamma-glutamyltransferase; hypertension; metabolic syndrome;
   sex-specific; Chinese population
ID FATTY LIVER-DISEASE; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE;
   RISK-FACTORS; GLUTAMYLTRANSFERASE; INFLAMMATION; PREDICTOR; ENZYMES;
   CANCER; LEVEL
AB Background: Higher serum gamma-glutamyltransferase (GGT) is associated with high risk of hypertension. We aimed to examine the association between sex-specific serum GGT levels and incident of hypertension in a Chinese population without metabolic syndrome.
   Methods: Participants who were free of hypertension and metabolic syndrome from the First Affiliated Hospital of Wenzhou Medical University between 2009 and 2014 were included. Participants were grouped into sex-specific quartiles of GGT levels (Q1-Q4) defined as: <= 19, 20-26, 27-38, and >= 39 U/L for male; <= 12, 13-15, 16-19, and >= 20 U/L for female. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for incidence of hypertension according to sex-specific quartiles of GGT levels. Kaplan-Meier analysis and interaction analysis were conducted.
   Results: Among 38,806 participants included (average age 36.0 years, 54.0% men), 4,505 of them developed hypertension. In the overall study population, using Q1 as the reference group, participants in Q2, Q3, and Q4 showed a higher risk of developing hypertension, with HRs (95% CIs) of 1.126 (1.029-1.232), 1.187 (1.083-1.302), and 1.300 (1.182-1.431), respectively (P < 0.001), after adjusting for known confounders. Sex-specific analysis showed that the adjusted HRs for participants in Q4 (reference: Q1) were greater in females [1.321 (1.100-1.586, P < 0.001)] than in males [1.268 (1.133-1.420, P < 0.001)] (P for interaction = 0.047). Moreover, interaction analysis showed that this association was consistently observed when the participants were stratified by age, body mass index, and fatty liver status.
   Conclusion: Among Chinese adults without metabolic syndrome, serum GGT level was positively associated with incidence of hypertension, and the association was stronger in females than in males.
C1 [Wu, Xiaoyun] Wenzhou Med Univ, Dept Rehabil, Affiliated Hosp 1, Wenzhou, Peoples R China.
   [Liang, Dongjie; Sun, Junfang; Wu, Shengjie] Wenzhou Med Univ, Dept Cardiol, Affiliated Hosp 1, Wenzhou, Peoples R China.
   [Liang, Dongjie; Wu, Shengjie] Key Lab Cardiovasc Dis Wenzhou, Wenzhou, Peoples R China.
   [Lin, Yanyan] Wenzhou Med Univ, Dept Neurol, Affiliated Hosp 1, Wenzhou, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University; Wenzhou Medical
   University
RP Wu, SJ (corresponding author), Wenzhou Med Univ, Dept Cardiol, Affiliated Hosp 1, Wenzhou, Peoples R China.; Wu, SJ (corresponding author), Key Lab Cardiovasc Dis Wenzhou, Wenzhou, Peoples R China.
EM wusj120@163.com
RI liang, dongjie/ABD-0926-2022
CR Ali SS, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0097-7
   Bonnet F, 2017, J HYPERTENS, V35, P493, DOI 10.1097/HJH.0000000000001204
   Bulusu S, 2016, ANN CLIN BIOCHEM, V53, P312, DOI 10.1177/0004563215597010
   Cantero I, 2017, NUTRIENTS, V9, DOI 10.3390/nu9070667
   Cheung BMY, 2011, CLIN CHIM ACTA, V412, P1326, DOI 10.1016/j.cca.2011.03.030
   Chow CK, 2013, JAMA-J AM MED ASSOC, V310, P959, DOI 10.1001/jama.2013.184182
   Dietrich S, 2016, HYPERTENSION, V68, P471, DOI 10.1161/HYPERTENSIONAHA.116.07292
   Emdin M, 2005, CIRCULATION, V112, P2078, DOI 10.1161/CIRCULATIONAHA.105.571919
   Fan JG, 2007, J GASTROEN HEPATOL, V22, P794, DOI 10.1111/j.1440-1746.2007.04952.x
   Ford ES, 2008, DIABETES CARE, V31, P1138, DOI 10.2337/dc08-1138
   Guthold R, 2020, LANCET CHILD ADOLESC, V4, P23, DOI 10.1016/S2352-4642(19)30323-2
   Guzik TJ, 2017, HYPERTENSION, V70, P660, DOI 10.1161/HYPERTENSIONAHA.117.07802
   Jimba S, 2009, METAB SYNDR RELAT D, V7, P411, DOI 10.1089/met.2008.0082
   Jung CH, 2011, CLIN ENDOCRINOL, V75, P328, DOI 10.1111/j.1365-2265.2011.04060.x
   Kim CH, 2009, DIABETES-METAB RES, V25, P64, DOI 10.1002/dmrr.890
   Kim NH, 2012, CLIN EXP HYPERTENS, V34, P402, DOI 10.3109/10641963.2012.665539
   Koehler EM, 2013, CLIN GASTROENTEROL H, V11, P1201, DOI 10.1016/j.cgh.2012.12.031
   Kunutsor SK, 2016, LIVER INT, V36, P1723, DOI 10.1111/liv.13221
   Kunutsor SK, 2015, J HYPERTENS, V33, P2373, DOI 10.1097/HJH.0000000000000763
   Kunutsor SK, 2015, ATHEROSCLEROSIS, V238, P356, DOI 10.1016/j.atherosclerosis.2014.12.045
   Lee DH, 2004, J HUM HYPERTENS, V18, P803, DOI 10.1038/sj.jhh.1001742
   Lee DH, 2003, CLIN CHEM, V49, P1358, DOI 10.1373/49.8.1358
   Li M, 2015, J HYPERTENS, V33, P704, DOI 10.1097/HJH.0000000000000462
   Lin CM, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-09719-8
   Ndrepepa G, 2016, ANN TRANSL MED, V4, DOI 10.21037/atm.2016.12.27
   Olsen MH, 2015, LANCET, V386, P637, DOI 10.1016/S0140-6736(15)61178-3
   Ryoo JH, 2015, INT J CARDIOL, V183, P258, DOI 10.1016/j.ijcard.2014.10.152
   Saw J, 2017, J AM COLL CARDIOL, V69, P262, DOI 10.1016/j.jacc.2016.10.019
   Seo Y, 2017, CIRC J, V81, P783, DOI 10.1253/circj.CJ-17-0409
   Stranges S, 2005, HYPERTENSION, V46, P1186, DOI 10.1161/01.HYP.0000185688.81320.4d
   Wassmann S, 2001, CIRCULATION, V103, P435
   Whitfield JB, 2001, CRIT REV CL LAB SCI, V38, P263, DOI 10.1080/20014091084227
   Wu SJ, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000000842
   Wu SJ, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000000802
NR 34
TC 4
Z9 6
U1 0
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD APR 16
PY 2021
VL 8
AR 644044
DI 10.3389/fcvm.2021.644044
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA RU9CC
UT WOS:000645436600001
PM 33937358
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Shivappa, N
   Hébert, JR
   Veronese, N
   Caruso, MG
   Notarnicola, M
   Maggi, S
   Stubbs, B
   Firth, J
   Fornaro, M
   Solmi, M
AF Shivappa, Nitin
   Hebert, James R.
   Veronese, Nicola
   Caruso, Maria Gabriella
   Notarnicola, Maria
   Maggi, Stefania
   Stubbs, Brendon
   Firth, Joseph
   Fornaro, Michele
   Solmi, Marco
TI The relationship between the dietary inflammatory index
   (DII<SUP>®</SUP>) and incident depressive symptoms: A longitudinal
   cohort study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Health behavior; Neuroimmunology; Old age
ID METABOLIC SYNDROME; MAJOR DEPRESSION; RISK-FACTOR; METAANALYSIS;
   ASSOCIATION; PREVALENCE; DISEASE; OBESITY; CANCER; WOMEN
AB Background: Diet is a common source of inflammation, and inflammation is associated with depression. We examined the association between the dietary inflammatory index (DII (R)), a validated measure of inflammatory potential of the diet, and risk of depression in a cohort of older North American adults.
   Methods: This longitudinal study, with a follow-up of 8 years, included 3648 participants (1577 males, 2071 females; mean age: 60.6 years) with/at risk of knee osteoarthritis. DII (R) scores were calculated using the validated Block Brief 2000 Food-Frequency Questionnaire. Center for Epidemiological Studies Depression-20 scale was used to define depressive symptoms. The relationship between baseline DII (R) score and incident depression was assessed through Cox's regression analysis, adjusted for potential confounders, and reported as hazard ratios (HRs).
   Results: In total, 837 individuals (310 men and 527 women) developed incident depressive symptoms over the course of 8 years. Participants in the most pro-inflammatory group (quartile 4) had approximately 24% higher risk of developing depressive symptoms compared to subjects with the most anti-inflammatory diet (HR: 1.24; 95% CI: 1.01-1.53; p = 0.04).
   Conclusion: These results suggest that a pro-inflammatory diet may be associated with higher incidence of depressive symptoms in a cohort of older Americans. Transitioning to a more anti-inflammatory diet may reduce depression risk.
C1 [Shivappa, Nitin; Hebert, James R.] Univ South Carolina, Arnold Sch Publ Hlth, Canc Prevent & Control Program, Columbia, SC 29208 USA.
   [Shivappa, Nitin; Hebert, James R.] Univ South Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA.
   [Shivappa, Nitin; Hebert, James R.] Connecting Hlth Innovat LLC, Columbia, SC 29201 USA.
   [Veronese, Nicola; Maggi, Stefania] CNR, Neurosci Inst, Aging Branch, Padua, Italy.
   [Veronese, Nicola; Caruso, Maria Gabriella; Notarnicola, Maria] IRCCS S de Bellis, Natl Inst Gastroenterol, Res Hosp, Lab Nutr Biochem, Bari, Italy.
   [Veronese, Nicola; Caruso, Maria Gabriella] IRCCS S de Bellis, Natl Inst Gastroenterol, Res Hosp, Ambulatory Clin Nutr, Bari, Italy.
   [Stubbs, Brendon] South London & Maudsley NHS Fdn Trust, London, England.
   [Stubbs, Brendon] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England.
   [Stubbs, Brendon] Anglia Ruskin Univ, Fac Hlth Social Care & Educ, Chelmsford, England.
   [Firth, Joseph] Univ Western Sydney, NICM Hlth Res Inst, Sydney, NSW, Australia.
   [Fornaro, Michele] Univ Naples Federico II, Dept Psychiat, Naples, Italy.
   [Solmi, Marco] Univ Padua, Psychiat Unit, Dept Neurosci, Via Giustiniani, I-35128 Padua 2, Italy.
C3 University of South Carolina System; University of South Carolina
   Columbia; University of South Carolina System; University of South
   Carolina Columbia; Connecting Health Innovations LLC; Consiglio
   Nazionale delle Ricerche (CNR); IRCCS Saverio de Bellis; IRCCS Saverio
   de Bellis; South London & Maudsley NHS Trust; University of London;
   King's College London; Anglia Ruskin University; Western Sydney
   University; University of Naples Federico II; University of Padua
RP Solmi, M (corresponding author), Univ Padua, Psychiat Unit, Dept Neurosci, Via Giustiniani, I-35128 Padua 2, Italy.
EM marco.solmi83@gmail.com
RI Stubbs, Brendon/X-1904-2018; solmi, marco/K-3906-2018; Shivappa,
   Nitin/X-2215-2018; Firth, Joseph/JOZ-1679-2023; Hebert,
   James/IUO-5628-2023; Veronese, Nicola/K-4343-2018; Stubbs,
   Brendon/C-5696-2015
OI Veronese, Nicola/0000-0002-9328-289X; Fornaro,
   Michele/0000-0002-9647-0853; Caruso, Maria
   Gabriella/0000-0003-4518-6307; Stubbs, Brendon/0000-0001-7387-3791;
   solmi, marco/0000-0003-4877-7233
FU National Institutes of Health, a branch of the Department of Health and
   Human Services [N01-AR-2-2258, N01-AR-2-2259, N01-AR-2-2260,
   N01-AR-2-2261, N01-AR-2-2262]; Merck Research Laboratories; Novartis
   Pharmaceuticals Corporation; GlaxoSmithKline; Pfizer, Inc.; United
   States National Institute for Diabetes, Digestive and Kidney Diseases
   [R44DK103377]
FX The OAI is a public-private partnership comprised of five contracts
   (N01-AR-2-2258; N01-AR-2-2259; N01-AR-2-2260; N01-AR-2-2261;
   N01-AR-2-2262) funded by the National Institutes of Health, a branch of
   the Department of Health and Human Services, and conducted by the OAI
   Study Investigators. Private funding partners include Merck Research
   Laboratories; Novartis Pharmaceuticals Corporation, GlaxoSmithKline; and
   Pfizer, Inc. Private sector funding for the OAI is managed by the
   Foundation for the http://dx.doi.org/10.13039/100000002. This manuscript
   was prepared using an OAI public use data set and does not necessarily
   reflect the opinions or views of the OAI investigators, the NIH, or the
   private funding partners. NS and JRH were supported by the United States
   National Institute for Diabetes, Digestive and Kidney Diseases (grant
   no. R44DK103377). Sponsor's role: the sponsors had no role in the
   design, methods, subject recruitment, data collection, analysis or
   preparation of this paper.
CR Adjibade M, 2017, J NUTR, V147, P879, DOI 10.3945/jn.116.245167
   Aeberli I, 2011, AM J CLIN NUTR, V94, P479, DOI 10.3945/ajcn.111.013540
   Akbaraly TN, 2016, CLIN PSYCHOL SCI, V4, P1125, DOI 10.1177/2167702616645777
   [Anonymous], J AM MED DIRECTORS A
   [Anonymous], DEMENTIA RISK ESTIMA
   [Anonymous], J NUTR HLTH AGING
   [Anonymous], J BONE MINER RES OFF
   [Anonymous], 2009, TOLERANCE VARIANCE I
   [Anonymous], CLIN NUTR EDINBURGH
   [Anonymous], AGE AGEING
   [Anonymous], 1982, SOCIAL SCI MED
   [Anonymous], MOL NEUROBIOL
   Bennett S, 2014, MATURITAS, V79, P184, DOI 10.1016/j.maturitas.2014.05.009
   Block G, 1990, Epidemiology, V1, P58, DOI 10.1097/00001648-199001000-00013
   Bromet E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-90
   Cavicchia PP, 2009, J NUTR, V139, P2365, DOI 10.3945/jn.109.114025
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   Eby GA, 2006, MED HYPOTHESES, V67, P362, DOI 10.1016/j.mehy.2006.01.047
   Ferrari AJ, 2013, PLOS MED, V10, DOI 10.1371/journal.pmed.1001547
   Fuster D, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000000607
   Ghazavi A, 2013, IMMUNOL LETT, V153, P22, DOI 10.1016/j.imlet.2013.07.001
   González-Reimers E, 2014, WORLD J GASTROENTERO, V20, P14660, DOI 10.3748/wjg.v20.i40.14660
   Hackett ML, 2014, INT J STROKE, V9, P1017, DOI 10.1111/ijs.12357
   Jacka FN, 2017, BMC MED, V15, DOI 10.1186/s12916-017-0791-y
   JONCKHEERE AR, 1954, BIOMETRIKA, V41, P133, DOI 10.2307/2333011
   Katz JN, 1996, MED CARE, V34, P73, DOI 10.1097/00005650-199601000-00006
   Kessler RC, 2013, ANNU REV PUBL HEALTH, V34, P119, DOI 10.1146/annurev-publhealth-031912-114409
   Köhler CA, 2017, ACTA PSYCHIAT SCAND, V135, P373, DOI 10.1111/acps.12698
   Lichtman JH, 2014, CIRCULATION, V129, P1350, DOI 10.1161/CIR.0000000000000019
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Ng QX, 2018, J AFFECT DISORDERS, V228, P13, DOI 10.1016/j.jad.2017.11.063
   Rackley S, 2012, PSYCHIAT CLIN N AM, V35, P231, DOI 10.1016/j.psc.2011.11.001
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Ramallal R, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0135221
   Read JR, 2017, J AFFECT DISORDERS, V221, P36, DOI 10.1016/j.jad.2017.06.009
   Rotella F, 2013, DIABETES RES CLIN PR, V99, P98, DOI 10.1016/j.diabres.2012.11.022
   Rotella F, 2013, J CLIN PSYCHIAT, V74, P32, DOI 10.4088/JCP.12r07922
   Sánchez-Villegas A, 2015, BRIT J NUTR, V114, P1471, DOI 10.1017/S0007114515003074
   Sanchez-Villegas A, 2013, BMC MED, V11, DOI [10.1186/1741-7015-11-3, 10.1186/1741-7015-11-208]
   Shivappa N, 2016, BRIT J NUTR, V116, P1077, DOI 10.1017/S0007114516002853
   Shivappa N, 2014, PUBLIC HEALTH NUTR, V17, P1825, DOI 10.1017/S1368980013002565
   Shivappa N, 2014, PUBLIC HEALTH NUTR, V17, P1689, DOI 10.1017/S1368980013002115
   Slyepchenko A, 2016, CURR PHARM DESIGN, V22, P6087, DOI 10.2174/1381612822666160922165706
   SMITH RS, 1991, MED HYPOTHESES, V35, P298, DOI 10.1016/0306-9877(91)90272-Z
   Tabung FK, 2015, ANN EPIDEMIOL, V25, P398, DOI 10.1016/j.annepidem.2015.03.009
   Tabung FK, 2015, CANCER CAUSE CONTROL, V26, P399, DOI 10.1007/s10552-014-0515-y
   Tsilidis KK, 2015, BMJ-BRIT MED J, V350, DOI 10.1136/bmj.g7607
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vos T, 2015, LANCET, V386, P743, DOI 10.1016/S0140-6736(15)60692-4
   Washburn RA, 1999, J CLIN EPIDEMIOL, V52, P643, DOI 10.1016/S0895-4356(99)00049-9
   Willett WC, 1997, AM J CLIN NUTR, V65, P1220, DOI 10.1093/ajcn/65.4.1220S
   Wirth MD, 2017, HEALTH PSYCHOL, V36, P760, DOI 10.1037/hea0000514
   Wirth MD, 2014, J OCCUP ENVIRON MED, V56, P986, DOI 10.1097/JOM.0000000000000213
   Wohleb ES, 2016, NAT REV NEUROSCI, V17, P497, DOI 10.1038/nrn.2016.69
   Wood LG, 2015, CLIN EXP ALLERGY, V45, P177, DOI 10.1111/cea.12323
   Wu Q, 2016, MEDICINE, V95, P1, DOI 10.1097/MD.0000000000002815
   Yirmiya R, 2015, TRENDS NEUROSCI, V38, P637, DOI 10.1016/j.tins.2015.08.001
   Zunszain Patricia A, 2013, Curr Top Behav Neurosci, V14, P135, DOI 10.1007/7854_2012_211
NR 58
TC 55
Z9 57
U1 6
U2 26
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD AUG 1
PY 2018
VL 235
BP 39
EP 44
DI 10.1016/j.jad.2018.04.014
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA GG4SQ
UT WOS:000432686900006
PM 29649709
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Radhakrishnan, R
   Kaser, M
   Guloksuz, S
AF Radhakrishnan, Rajiv
   Kaser, Muzaffer
   Guloksuz, Sinan
TI The Link Between the Immune System, Environment, and Psychosis
SO SCHIZOPHRENIA BULLETIN
LA English
DT Article
DE psychosis; schizophrenia; inflammation; immune system; cytokine;
   environment; cannabis; social defeat; childhood trauma
ID PERIPHERAL INFLAMMATION; SCHIZOPHRENIA; NEUROINFLAMMATION;
   PSYCHOPATHOLOGY; ASSOCIATION; DEPRESSION; DISORDERS; STRESS; RISK; PET
AB The last decade has witnessed a burgeoning interest in studies exploring the link between psychosis spectrum disorders (PSD) and altered immune function. While epidemiological and clinical studies point to evidence for increased peripheral inflammatory markers in PSD, it is not clear whether peripheral inflammation correlates with central inflammation in the brain. Furthermore, these studies are confounded by multiple methodological and disorder-related factors such as antipsychotic medications, smoking, obesity, and metabolic syndrome, all of which independently contribute to altered inflammation. Clinical and animal studies provide encouraging evidence that inflammatory processes can define-trans-diagnostic neuropsychiatric domains such as-positive/negative valence, affective dysregulation, and cognitive impairment. In this commentary, we speculate on whether inflammation-mediated pathways may serve as a final-common pathway for environmental risk factors of early-childhood adversity, adolescent cannabis use, social exclusion, and on the possible mechanisms mediating the pathophysiology of PSD. We propose an integrative framework and suggest future research strategies that may help disentangle the link between immune dysfunction and PSD.
C1 [Radhakrishnan, Rajiv; Guloksuz, Sinan] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA.
   [Kaser, Muzaffer] Univ Cambridge, Dept Psychiat, Cambridge, England.
   [Kaser, Muzaffer] Cambridgeshire & Peterborough NHS Fdn Trust, Cambridge, England.
   [Guloksuz, Sinan] Maastricht Univ, Med Ctr, Dept Psychiat & Psychol, POB 616, NL-6200 MD Maastricht, Netherlands.
C3 Yale University; University of Cambridge; Maastricht University
RP Guloksuz, S (corresponding author), Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA.; Guloksuz, S (corresponding author), Maastricht Univ, Med Ctr, Dept Psychiat & Psychol, POB 616, NL-6200 MD Maastricht, Netherlands.
EM sinan.guloksuz@maastrichtuniversity.nl
RI Kaser, Muzaffer/N-7799-2013; Guloksuz, Sinan/AAH-1076-2019;
   Radhakrishnan, Rajiv/ADP-4678-2022
OI Radhakrishnan, Rajiv/0000-0002-8220-655X; Kaser,
   Muzaffer/0000-0002-1106-1613; Guloksuz, Sinan/0000-0002-6626-1874
FU European Community [HEALTH-F2-2009-241909]; Dana Foundation David
   Mahoney Program; Thomas P. Detre Award in Translational Neuroscience
   Research
FX S.G. would like to acknowledge the European Community's Seventh
   Framework Program under grant agreement no. HEALTH-F2-2009-241909
   (Project EU-GEI). R.R. is supported by the Dana Foundation David Mahoney
   Program and Thomas P. Detre Award in Translational Neuroscience
   Research.
CR Alexandre K, 2017, SCHIZOPHR B
   Altinoz M, 2016, MOL PSYCHIAT
   [Anonymous], BRAIN BEHAV IMMUN
   Baumeister D, 2016, MOL PSYCHIATR, V21, P642, DOI 10.1038/mp.2015.67
   Brodin P, 2015, CELL, V160, P37, DOI 10.1016/j.cell.2014.12.020
   Bulzacka E, 2016, SCHIZOPHRENIA BULL, V42, P1290, DOI 10.1093/schbul/sbw029
   Cabrera B, 2016, PSYCHOL MED, V46, P2133, DOI 10.1017/S0033291716000659
   Calcia MA, 2016, PSYCHOPHARMACOLOGY, V233, P1637, DOI 10.1007/s00213-016-4218-9
   Capuron L, 2017, CURR TOP BEHAV NEURO, V31, P31, DOI 10.1007/7854_2016_14
   Churchill L, 2006, BRAIN RES, V1120, P64, DOI 10.1016/j.brainres.2006.08.083
   Cole SW, 2014, PLOS GENET, V10, DOI 10.1371/journal.pgen.1004601
   Coughlin JM, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.40
   Danese A, 2017, NEUROPSYCHOPHARMACOL, V42, P99, DOI 10.1038/npp.2016.198
   Doorduin J, 2009, J NUCL MED, V50, P1801, DOI 10.2967/jnumed.109.066647
   Goldsmith DR, 2016, MOL PSYCHIATR, V21, P1696, DOI 10.1038/mp.2016.3
   Guloksuz S, 2015, PSYCHOL MED, V45, P2389, DOI 10.1017/S0033291715000380
   Harrison NA, 2014, BIOL PSYCHIAT, V76, P585, DOI 10.1016/j.biopsych.2014.01.005
   Howes OD, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/tp.2016.278
   Kenk M, 2015, SCHIZOPHRENIA BULL, V41, P85, DOI 10.1093/schbul/sbu157
   Khandaker GM, 2014, JAMA PSYCHIAT, V71, P1121, DOI 10.1001/jamapsychiatry.2014.1332
   Kozela E, 2016, J NEUROINFLAMM, V13, DOI 10.1186/s12974-016-0603-x
   McAfoose J, 2009, NEUROSCI BIOBEHAV R, V33, P355, DOI 10.1016/j.neubiorev.2008.10.005
   Morris G, 2016, CURR PHARM DESIGN, V22, P963, DOI 10.2174/1381612822666151215102420
   Notter T, 2017, MOL PSYCHIAT
   Perkins DO, 2015, SCHIZOPHRENIA BULL, V41, P419, DOI 10.1093/schbul/sbu099
   Pishva E, 2014, SOC PSYCH PSYCH EPID, V49, P337, DOI 10.1007/s00127-014-0831-2
   Radhakrishnan R, 2014, FRONT PSYCHIATRY, V5, DOI 10.3389/fpsyt.2014.00054
   Ripke S, 2014, NATURE, V511, P421, DOI 10.1038/nature13595
   Schiermeier Q, 2016, NATURE, V532, P18, DOI [10.1038/nature.2016.19672, 10.1038/nature.2016.20893]
   Schwieler L, 2015, J PSYCHIATR NEUROSCI, V40, P126, DOI 10.1503/jpn.140126
   Sekar A, 2016, NATURE, V530, P177, DOI 10.1038/nature16549
   Selten J-P., 2016, SCHIZOPHR RES
   Shirts BH, 2008, SCHIZOPHR RES, V106, P268, DOI 10.1016/j.schres.2008.07.017
   Suárez-Pinilla P, 2014, BRAIN BEHAV IMMUN, V40, P269, DOI 10.1016/j.bbi.2014.01.018
   Trépanier MO, 2016, MOL PSYCHIATR, V21, P1009, DOI 10.1038/mp.2016.90
   van Os J, 2014, SCHIZOPHRENIA BULL, V40, P729, DOI 10.1093/schbul/sbu069
   Zamberletti E, 2015, EUR NEUROPSYCHOPHARM, V25, P2404, DOI 10.1016/j.euroneuro.2015.09.021
NR 37
TC 65
Z9 66
U1 3
U2 26
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0586-7614
EI 1745-1701
J9 SCHIZOPHRENIA BULL
JI Schizophr. Bull.
PD JUL
PY 2017
VL 43
IS 4
BP 693
EP 697
DI 10.1093/schbul/sbx057
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EX6HU
UT WOS:000403344200006
PM 28969353
OA Green Published
DA 2025-06-11
ER

PT J
AU Zangara, MT
   Johnston, I
   Johnson, EE
   McDonald, C
AF Zangara, Megan T.
   Johnston, Isabel
   Johnson, Erin E.
   McDonald, Christine
TI Mediators of Metabolism: An Unconventional Role for NOD1 and NOD2
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE NLR; metabolism; ER stress; mitochondria; hypoxia; high fat diet;
   metabolic syndrome; insulin resistance; obesity; diabetes
ID INNATE IMMUNE-RESPONSES; INSULIN-RESISTANCE; ER STRESS; ADIPOSE-TISSUE;
   INDUCED INFLAMMATION; ACTIVATION; EXPRESSION; OBESITY; DYSBIOSIS;
   GLUCOSE
AB In addition to their classical roles as bacterial sensors, NOD1 and NOD2 have been implicated as mediators of metabolic disease. Increased expression of NOD1 and/or NOD2 has been reported in a range of human metabolic diseases, including obesity, diabetes, non-alcoholic fatty liver disease, and metabolic syndrome. Although NOD1 and NOD2 share intracellular signaling pathway components, they are differentially upregulated on a cellular level and have opposing impacts on metabolic disease development in mouse models. These NOD-like receptors may directly mediate signaling downstream of cell stressors, such as endoplasmic reticulum stress and calcium influx, or in response to metabolic signals, such as fatty acids and glucose. Other studies suggest that stimulation of NOD1 or NOD2 by their bacterial ligands can result in inflammation, altered insulin responses, increased reactive oxygen signaling, and mitochondrial dysfunction. The activating stimuli for NOD1 and NOD2 in the context of metabolic disease are controversial and may be a combination of both metabolic and circulating bacterial ligands. In this review, we will summarize the current knowledge of how NOD1 and NOD2 may mediate metabolism in health and disease, as well as highlight areas of future investigation.
C1 [Zangara, Megan T.; Johnston, Isabel; Johnson, Erin E.; McDonald, Christine] Cleveland Clin, Lerner Res Inst, Dept Inflammat & Immun, Cleveland, OH 44195 USA.
   [Zangara, Megan T.; McDonald, Christine] Case Western Reserve Univ, Cleveland Clin, Dept Mol Med, Lerner Coll Med, Cleveland, OH 44106 USA.
   [Johnson, Erin E.] John Carroll Univ, Dept Biol, University Hts, OH 44118 USA.
C3 Cleveland Clinic Foundation; University System of Ohio; Case Western
   Reserve University; Cleveland Clinic Foundation; University System of
   Ohio; John Carroll University
RP McDonald, C (corresponding author), Cleveland Clin, Lerner Res Inst, Dept Inflammat & Immun, Cleveland, OH 44195 USA.; McDonald, C (corresponding author), Case Western Reserve Univ, Cleveland Clin, Dept Mol Med, Lerner Coll Med, Cleveland, OH 44106 USA.
EM zangarm@ccf.org; johnsti@ccf.org; exjohnson@jcu.edu; mcdonac2@ccf.org
RI Zangara, Megan/JGD-4769-2023
OI Zangara, Megan/0000-0002-0884-9936; McDonald,
   Christine/0000-0002-6745-9487; Johnston, Isabel/0000-0002-2770-2841
FU Office of the Assistant Secretary of Defense for Health Affairs through
   the Congressionally Directed Medical Research Programs Peer Reviewed
   Medical Research Program [W81XWH1910488 (PR181846)]
FX This research was supported by the Office of the Assistant Secretary of
   Defense for Health Affairs through the Congressionally Directed Medical
   Research Programs Peer Reviewed Medical Research Program under Award No.
   W81XWH1910488 (PR181846) and philanthropic support from Cure for IBD and
   the McDonald Family Trust. Opinions, interpretations, conclusions, and
   recommendations are those of the authors and are not necessarily
   endorsed by the funders.
CR Afshin A, 2017, NEW ENGL J MED, V377, P13, DOI 10.1056/NEJMoa1614362
   Amar J, 2011, EMBO MOL MED, V3, P559, DOI 10.1002/emmm.201100159
   Bae J, 2014, AM J PHYSIOL-CELL PH, V306, pC918, DOI 10.1152/ajpcell.00249.2013
   Carlos D, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.01265
   Caruso R, 2014, IMMUNITY, V41, P898, DOI 10.1016/j.immuni.2014.12.010
   Cascio G, 2012, CURR DIABETES REV, V8, P2, DOI 10.2174/157339912798829241
   Cavallari JF, 2020, AM J PHYSIOL-ENDOC M, V319, pE305, DOI 10.1152/ajpendo.00181.2020
   Cavallari JF, 2020, AM J PHYSIOL-ENDOC M, V318, pE579, DOI 10.1152/ajpendo.00033.2020
   Cavallari JF, 2017, CELL METAB, V25, P1063, DOI 10.1016/j.cmet.2017.03.021
   Chan KL, 2017, CELL REP, V18, P2415, DOI 10.1016/j.celrep.2017.02.027
   Chapman TP, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.01495
   Chi W, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0097675
   Costa FRC, 2016, J EXP MED, V213, P1223, DOI 10.1084/jem.20150744
   Cuda C, 2012, GENES NUTR, V7, P427, DOI 10.1007/s12263-012-0287-5
   de Kort S, 2011, OBES REV, V12, P449, DOI 10.1111/j.1467-789X.2010.00845.x
   DeFronzo RA, 2009, DIABETES CARE, V32, pS157, DOI 10.2337/dc09-S302
   Denou E, 2015, EMBO MOL MED, V7, P259, DOI 10.15252/emmm.201404169
   Du PC, 2013, KIDNEY INT, V84, P265, DOI 10.1038/ki.2013.113
   Eguchi J, 2013, DIABETES, V62, P3394, DOI 10.2337/db12-1327
   Fan YH, 2016, P NATL ACAD SCI USA, V113, pE7818, DOI 10.1073/pnas.1611711113
   Hetz C, 2012, NAT REV MOL CELL BIO, V13, P89, DOI 10.1038/nrm3270
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Huang C, 2019, CELL REP, V29, P4525, DOI 10.1016/j.celrep.2019.11.105
   Huang W, 2016, EXP CLIN ENDOCR DIAB, V124, P512, DOI 10.1055/s-0042-105641
   Keestra-Gounder AM, 2016, NATURE, V532, P394, DOI 10.1038/nature17631
   Kim MS, 2011, NUTR RES PRACT, V5, P219, DOI 10.4162/nrp.2011.5.3.219
   Kwon MY, 2019, BMB REP, V52, P665, DOI 10.5483/BMBRep.2019.52.11.176
   Lappas M, 2014, J ENDOCRINOL, V222, P99, DOI 10.1530/JOE-14-0179
   le Roux CW, 2021, NAT REV ENDOCRINOL, V17, P71, DOI 10.1038/s41574-020-00449-y
   Levy A, 2020, P NATL ACAD SCI USA, V117, P1994, DOI 10.1073/pnas.1902788117
   Ma XD, 2020, EXP MOL PATHOL, V117, DOI 10.1016/j.yexmp.2020.104525
   Martinez-Medina M, 2014, GUT, V63, P116, DOI 10.1136/gutjnl-2012-304119
   Maurya CK, 2015, FREE RADICAL BIO MED, V89, P158, DOI 10.1016/j.freeradbiomed.2015.07.154
   Mendez JM, 2019, INFECT IMMUN, V87, DOI 10.1128/IAI.00826-18
   Molinaro R, 2019, J BIOL CHEM, V294, P9007, DOI 10.1074/jbc.RA119.007997
   Morigny P, 2016, BIOCHIMIE, V125, P259, DOI 10.1016/j.biochi.2015.10.024
   Mukherjee T, 2019, ARCH BIOCHEM BIOPHYS, V670, P69, DOI 10.1016/j.abb.2018.12.022
   Murugina NE, 2020, J BIOL CHEM, V295, P3099, DOI 10.1074/jbc.RA119.010589
   Nagpal R, 2018, J DIABETES RES, V2018, DOI 10.1155/2018/3462092
   Oakes SA, 2015, ANNU REV PATHOL-MECH, V10, P173, DOI 10.1146/annurev-pathol-012513-104649
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Ozbayer C, 2017, J CLIN PHARM THER, V42, P98, DOI 10.1111/jcpt.12482
   Purohit JS, 2013, BIOCHEM CELL BIOL, V91, P428, DOI 10.1139/bcb-2013-0049
   Rodriguez-Nunez I, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-00484-2
   Ruiz E, 2020, GUT MICROBES, V11, P350, DOI 10.1080/19490976.2019.1611152
   Schertzer JD, 2011, DIABETES, V60, P2206, DOI 10.2337/db11-0004
   Shiny A, 2013, CYTOKINE, V64, P564, DOI 10.1016/j.cyto.2013.08.003
   Singh K, 2018, GLIA, V66, P2427, DOI 10.1002/glia.23482
   Tamrakar AK, 2010, ENDOCRINOLOGY, V151, P5624, DOI 10.1210/en.2010-0437
   Thaiss CA, 2018, SCIENCE, V359, P1376, DOI 10.1126/science.aar3318
   Watanabe T, 2008, J CLIN INVEST, V118, P545, DOI [10.1172/JC133145, 10.1172/JCI33145]
   Waters H, 2018, AM OBESITY CRISIS EC
   Wellen KE, 2010, MOL CELL, V40, P323, DOI 10.1016/j.molcel.2010.10.004
   Winzell MS, 2004, DIABETES, V53, pS215, DOI 10.2337/diabetes.53.suppl_3.S215
   Zhang ZF, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18010031
   Zhao L, 2007, J BIOL CHEM, V282, P11618, DOI 10.1074/jbc.M608644200
   Zhao L, 2011, AM J PHYSIOL-ENDOC M, V301, pE587, DOI 10.1152/ajpendo.00709.2010
   Zhou YJ, 2012, DIABETES METAB, V38, P538, DOI 10.1016/j.diabet.2012.08.001
   Zhou YJ, 2015, OBESITY, V23, P1394, DOI 10.1002/oby.21113
   Zhou Yi-jun, 2013, Chinese Medical Sciences Journal, V28, P211
NR 60
TC 24
Z9 26
U1 2
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB
PY 2021
VL 22
IS 3
AR 1156
DI 10.3390/ijms22031156
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA QD1PC
UT WOS:000615298400001
PM 33503814
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Liu, PJ
   Liao, EC
   Guo, CH
   Lu, MP
   Liao, H
   Liu, KL
AF Liu, P. J.
   Liao, E. C.
   Guo, C. H.
   Lu, M. P.
   Liao, H.
   Liu, K. L.
TI PHYTOCHEMICAL AND NUTRITIONAL SUPPLEMENT THERAPY FOR PATIENTS WITH
   SEVERE OBSTRUCTIVE SLEEP APNEA
SO CURRENT TOPICS IN NUTRACEUTICAL RESEARCH
LA English
DT Article
DE Inflammation; Nutritional Intervention; Oxidative Stress; Sleep Apnea;
   Supplement Therapy
ID OXIDATIVE STRESS; ENDOTHELIAL FUNCTION; PROTEIN; OBESITY; DISEASE; DIET;
   RISK
AB Obstructive sleep apnea is an increasingly common disease highly associated with metabolic syndrome. Lifestyle nzodifi cations and weight control are recommended for obese patients with obstructive sleep apnea. We designed a single-arm pre-post clinical trial assessing 29 male participants aged 39.17 +/- 7.30 years with severe obstructive sleep apnea. They received a 12 week intervention consisting of a specific pbytochemical-containing medical functional food fish oil vitamin C, and coenzyme Q10. Anthropometric measurements, polysomnography, Epworth Sleepiness Scale scores, health-related quality of life assessment, and multiple biochemical parameters were assessed. After the intervention, participants showed significant decreases in body weight; body mass index; neck, waist, and hip circumferences; waist-to-hip ratio; and body fat percentage. The apnea-hypopnea index decreased from 53.43 +/- 18.82 to 34.38 +/- 24.41 (P < 0.001). Oxygen desaturation index and Epworth Sleepiness Scale scores also decreased significantly. Participants experienced reductions in systolic and diastolic blood pressure (P = 0.004), and significantly fewer in metabolic syndrome variables (P = 0.001). Our results suggest that specific phytochemical-containing medical food and nutritional supplement intervention can lower anthroponzetric and metabolic variables, oxidative stress, inflammatory status, apnea-hypopnea index, and oxygen desaturation index, and improve quality of life in obese subjects with severe obstructive sleep apnea.
C1 [Liu, P. J.] Cheng Ching Gen Hosp, Chung Kang Branch, Dept Otolaryngol, 966 Sec 4,Taiwan Blvd, Taichung 40764, Taiwan.
   [Liu, P. J.] Cheng Ching Gen Hosp, Chung Kang Branch, Sleep Ctr, 966 Sec 4,Taiwan Blvd, Taichung 40764, Taiwan.
   [Liao, E. C.] Mackay Med Coll, Dept Med, 46 Sec 3,Zhongzheng Rd, New Taipei 25245, Taiwan.
   [Guo, C. H.] Hung Kuang Univ, Inst Biomed Nutr, 1018 Sec 6,Taiwan Blvd, New Taipei 43302, Taiwan.
   [Lu, M. P.] Hung Kuang Univ, Dept Nutr, 5F 21,Ln 266,Dexing E Rd, Taipei 11148, Taiwan.
   [Liao, H.] Taipei Med Univ, Sch Nutr & Hlth Sci, 4F,17,Ln 113,Hsia Men St, Taipei 10082, Taiwan.
   [Liu, K. L.] Chung Shan Med Univ, Chung Shan Med Univ Hosp, Dept Nutr, Sch Nutr, 110 Sec 1,Jianguo N Rd, Taichung 40201, Taiwan.
C3 Mackay Medical College; Taipei Medical University; Chung Shan Medical
   University; Chung Shan Medical University Hospital
RP Liu, KL (corresponding author), Chung Shan Med Univ, Chung Shan Med Univ Hosp, Dept Nutr, Sch Nutr, 110 Sec 1,Jianguo N Rd, Taichung 40201, Taiwan.
EM kaililiu@csmu.edu.tw
CR Alzoghaibi Mohammed A, 2005, Sleep Breath, V9, P119, DOI 10.1007/s11325-005-0022-1
   Araghi MH, 2013, SLEEP, V36, P1553, DOI 10.5665/sleep.3056
   Asghari A, 2013, EUR ARCH OTO-RHINO-L, V270, P1131, DOI 10.1007/s00405-012-2157-6
   Chen PC, 2013, J NUTR HEALTH AGING, V17, P639, DOI 10.1007/s12603-013-0023-x
   DAVIES RJO, 1992, THORAX, V47, P101, DOI 10.1136/thx.47.2.101
   Dyugovskaya L, 2005, ANN NY ACAD SCI, V1051, P340, DOI 10.1196/annals.1361.076
   Eckert Danny J, 2008, Proc Am Thorac Soc, V5, P144, DOI 10.1513/pats.200707-114MG
   Grebe M, 2006, AM J RESP CRIT CARE, V173, P897, DOI 10.1164/rccm.200508-1223OC
   Johansson K, 2009, BMJ-BRIT MED J, V339, DOI 10.1136/bmj.b4609
   Ladesich JB, 2011, J CLIN SLEEP MED, V7, P391, DOI 10.5664/JCSM.1198
   Lee SD, 2012, SLEEP BREATH, V16, P511, DOI 10.1007/s11325-011-0536-7
   Lerman RH, 2010, J CLIN LIPIDOL, V4, P59, DOI 10.1016/j.jacl.2009.11.002
   Lerman RH, 2008, NUTR METAB, V5, DOI 10.1186/1743-7075-5-29
   Lui MMS, 2009, CHEST, V135, P950, DOI 10.1378/chest.08-1798
   Lukaczer D, 2006, NUTRITION, V22, P104, DOI 10.1016/j.nut.2005.05.007
   Minich DM, 2010, J NUTR METAB, V2010, DOI 10.1155/2010/467316
   Minville C, 2014, CHEST, V145, P525, DOI 10.1378/chest.13-0938
   Nadeem R, 2013, J CLIN SLEEP MED, V9, P1003, DOI 10.5664/jcsm.3070
   Ntalapascha M, 2013, SLEEP BREATH, V17, P549, DOI 10.1007/s11325-012-0718-y
   Papandreou C, 2012, EUR RESPIR J, V39, P1398, DOI 10.1183/09031936.00103411
   Peppard PE, 2000, JAMA-J AM MED ASSOC, V284, P3015, DOI 10.1001/jama.284.23.3015
   Quinzii CM, 2010, DEV DISABIL RES REV, V16, P183, DOI 10.1002/ddrr.108
   Sawyer AM, 2011, SLEEP MED REV, V15, P343, DOI 10.1016/j.smrv.2011.01.003
   Stål PS, 2012, RESPIRATION, V83, P407, DOI 10.1159/000336040
   Tousoulis D, 2014, ATHEROSCLEROSIS, V232, P10, DOI 10.1016/j.atherosclerosis.2013.10.014
   Yamauchi M, 2008, ANTIOXID REDOX SIGN, V10, P755, DOI 10.1089/ars.2007.1946
   Young T, 2008, SLEEP, V31, P1071
NR 27
TC 0
Z9 0
U1 0
U2 5
PU NEW CENTURY HEALTH PUBLISHERS, LLC
PI COPPELL
PA PO BOX 175, COPPELL, TX 75019 USA
SN 1540-7535
J9 CURR TOP NUTRACEUT R
JI Curr. Top. Nutraceutical Res.
PY 2017
VL 15
IS 2
BP 87
EP 95
PG 9
WC Nutrition & Dietetics; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Pharmacology & Pharmacy
GA FH8DM
UT WOS:000411422000006
DA 2025-06-11
ER

PT J
AU Benharrat, LI
   Senouci, A
   Benhabib, W
   Mekki, K
AF Benharrat, Latifa Imen
   Senouci, Azzeddine
   Benhabib, Wassila
   Mekki, Khedidja
TI Omega 3 Supplementation Improves Inflammation and Antioxidant Defense in
   Women with Polycystic Ovary Syndrome
SO CURRENT NUTRITION & FOOD SCIENCE
LA English
DT Article
DE Oxidative status; Inflammation; Metabolic syndrome; Omega 3;
   Dyslipidemia; Hyperglycemia; Polycystic ovary syndrome
ID OXIDATIVE STRESS; OMEGA-3-FATTY-ACIDS
AB Background: Polycystic ovary syndrome (PCOS) is the most common female endocrine disorder and is accompanied by metabolic syndrome (MS), a risk factor for cardiovascular disorders.
   Objective: To evaluate the effect of Omega 3 on the improvement of some metabolic parameters.
   Materials/methods: Sixty women (29 +/- 6 years) with PCOS and MS were randomized into two groups: 30 received supplementation with omega-3 (Doppelherz, Activ, Germany), 3g/day (1g per capsule and 3 capsules/day), (180mg Eicosapentaenoic Acid (EPA)/120mg Docosahexaenoic Acid DHA per day), and 30 were used as controls. Blood samples were drawn at baseline (T0), 3 weeks (T1) and 6 weeks (T2) after start of treatment. We analysed glycemia, lipid profile, markers of inflammation and oxidative stress.
   Results: In omega-3 group compared to control, a reduction (p<0.05) in glucose levels was noted at T1 and T2. C-reactive protein (CRP) concentrations were decreased (-25%) at T2. Oxidative stress remain unchanged, but the activity of superoxide dismutase increased as well as the concentrations of Catalase and thiols at T1 and T2 (p<0.001).
   Conclusion: Omega 3 supplementation improves hyperglycemia, inflammation, and antioxidant defense in PCOS women with MS, and may lead to decreased cardiovascular complications.
C1 [Benharrat, Latifa Imen; Senouci, Azzeddine; Mekki, Khedidja] Univ Oran1, Fac Nat & Life Sci, Lab Clin & Metab Nutr, Oran 31100, Algeria.
   [Benhabib, Wassila] Univ Hosp Oran, Dept Epidemiol, Oran 31037, Algeria.
RP Mekki, K (corresponding author), Univ Oran1, Fac Nat & Life Sci, Lab Clin & Metab Nutr, Themat Agcy Res Hlth Sci, Oran, Algeria.
EM khmekki@hotmail.com
RI SENOUCI, Azzeddine/LKK-0511-2024; MEKKI, Khedidja/K-3832-2016
OI MEKKI, Khedidja/0000-0001-8783-3088; Senouci,
   Azzeddine/0000-0003-4684-6602
FU Thematic Agency of Research in Health Sciences; Oran, Algeria
FX This work was supported by the Thematic Agency of Research in Health
   Sciences. Oran, Algeria
CR ABDELAZIM IA, 2015, ASIAN PAC J REPROD, V4, P44, DOI DOI 10.1016/S2305-0500(14)60057-9
   Barber TM, 2019, CLIN MED INSIGHTS-RE, V13, DOI 10.1177/1179558119874042
   Barrea L, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102278
   Calder PC, 2015, BBA-MOL CELL BIOL L, V1851, P469, DOI 10.1016/j.bbalip.2014.08.010
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Douglas CC, 2006, FERTIL STERIL, V86, P411, DOI 10.1016/j.fertnstert.2005.12.054
   Enechukwu Chukwunonso Isaiah, 2019, Obstet Gynecol Sci, V62, P335
   Faghfoori Z, 2017, DIABETES METAB SYND, V11, pS429, DOI 10.1016/j.dsx.2017.03.030
   Gao HQ, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0528-0
   GOTH L, 1991, CLIN CHIM ACTA, V196, P143, DOI 10.1016/0009-8981(91)90067-M
   Innes JK, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21041362
   Jaliseh HK, 2017, FERTIL STERIL, V108, P1078, DOI 10.1016/j.fertnstert.2017.09.004
   Jamilian M, 2018, J AFFECT DISORDERS, V238, P32, DOI 10.1016/j.jad.2018.05.027
   Hidalgo-Mora JJ, 2020, MATURITAS, V132, P65, DOI 10.1016/j.maturitas.2019.12.002
   Khani B, 2017, J RES MED SCI, V22, DOI 10.4103/jrms.JRMS_644_16
   Koivuaho E, 2019, INT J OBESITY, V43, P1370, DOI 10.1038/s41366-019-0318-z
   LEVINE RL, 1990, METHOD ENZYMOL, V186, P464
   MARKLUND S, 1974, EUR J BIOCHEM, V47, P469
   Meital LT, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-49362-z
   Mohammadi M, 2019, INT J PREVENTIVE MED, V10, DOI 10.4103/ijpvm.IJPVM_576_17
   Phelan N, 2011, AM J CLIN NUTR, V93, P652, DOI 10.3945/ajcn.110.005538
   QUINTANILHA AT, 1982, BIOPHYS J, V37, P68, DOI 10.1016/S0006-3495(82)84603-1
   Rahmani E, 2017, MOL CELL ENDOCRINOL, V439, P247, DOI 10.1016/j.mce.2016.09.008
   Ranasinha S, 2015, CLIN ENDOCRINOL, V83, P879, DOI 10.1111/cen.12830
   SEDLAK J, 1968, ANAL BIOCHEM, V25, P192, DOI 10.1016/0003-2697(68)90092-4
   Vona R, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8267234
   Wang R, 2017, HUM REPROD, V32, P261, DOI 10.1093/humrep/dew287
   Woodman RJ, 2002, AM J CLIN NUTR, V76, P1007, DOI 10.1093/ajcn/76.5.1007
   Yang KL, 2018, REPROD BIOL ENDOCRIN, V16, DOI 10.1186/s12958-018-0346-x
NR 29
TC 1
Z9 1
U1 0
U2 6
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-4013
EI 2212-3881
J9 CURR NUTR FOOD SCI
JI Curr. Nutr. Food Sci.
PY 2022
VL 18
IS 2
BP 193
EP 200
DI 10.2174/1573401317666211104121725
PG 8
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA 1Z0HR
UT WOS:000808515900009
DA 2025-06-11
ER

PT J
AU Camacho, A
   Larsen, B
   McClelland, RL
   Morgan, C
   Criqui, MH
   Cushman, M
   Allison, MA
AF Camacho, Alvaro
   Larsen, Britta
   McClelland, Robyn L.
   Morgan, Cindy
   Criqui, Michael H.
   Cushman, Mary
   Allison, Matthew A.
TI Association of subsyndromal and depressive symptoms with inflammatory
   markers among different ethnic groups: The multi-ethnic study of
   atherosclerosis (MESA)
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Subsyndromal depression; Inflammation; Cardiovascular disease;
   Depressive states
ID CORONARY-HEART-DISEASE; SELF-RATED HEALTH; METABOLIC SYNDROME; COGNITIVE
   DECLINE; ANXIETY; WOMEN; RISK; MEDICATIONS; MIGRATION; HISTORY
AB Objective: Depressive symptoms are associated with inflammation yet the association between inflammation and different levels of depression remains unclear. Therefore, we studied the association of subsyndromal and depressive symptoms with inflammatory markers in a large multi ethnic cohort.
   Methods: C-reactive protein (CRP) (n=6269), interleukin-6 (IL-6) (n=6135) and tumor necrosis factor alpha (TNF-alpha) (n=1830) were measured in selected participants from the multi ethnic study of atherosclerosis (MESA). Subsyndromal depressive symptoms were defined as a CES-D value from 8 to 15, depressive symptoms as a CES-D >= 16 and normal as a CES-D <= 7. Depressive states (subsyndromal and depressed) were entered into multivariable linear regression models incrementally adjusting for demographic, behavioral, biologic and comorbidities.
   Results: Among 6289 participants not taking antidepressants and free from CVD, the mean age was 622, while 52% were women, 36.4% were Caucasian, 28.9% African-American, 22.3% Hispanics and 12.4% Chinese-American. Of the total, 24.2% had subsyndromal depression and 11.8% had depressive symptoms. Compared to the non depressed group and after controlling for demographics, there was no association between both subsyndromal and depressive symptoms with log CRP (beta = 0.01, p=0.80 and beta=-0.05, p=0.25 respectively), log IL-6 (beta=0.01, p=0.71 and beta=-0.04, p=0.07 respectively) and log TNF-alpha (beta=-0.03, p=0.29 and beta=0.06, p=0.18 respectively). Moreover, fully adjusted models showed no significant associations for log IL-6 and log TNF-alpha and the different depressive categories. However, with Full adjustment, we found a significant inverse association between depressive symptoms and In CRP (alpha=-0.10, p=0.01) that was not present for subsyndromal depression (beta=-0.05, p=0.11).
   Conclusion: Among participants not taking anti-depressants, subsyndromal depression is not associated with inflammation. However, depressive symptoms measured by CES-D >= 16 are associated with a lower inflammation (CRP). (C) 2014 Elsevier B.V. All rights reserved
C1 [Camacho, Alvaro; Larsen, Britta; Morgan, Cindy; Criqui, Michael H.; Allison, Matthew A.] Univ Calif San Diego, Dept Family & Prevent Med, San Diego, CA 92103 USA.
   [McClelland, Robyn L.] Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
   [Cushman, Mary] Univ Vermont, Dept Med, Burlington, VT USA.
C3 University of California System; University of California San Diego;
   University of Washington; University of Washington Seattle; University
   of Vermont
RP Camacho, A (corresponding author), 2417,Marshall Ave Suite 1, Imperial, CA 92251 USA.
EM acamacho@ucsd.edu
RI Criqui, Michael/AFT-6067-2022; Cushman, Mary/K-1157-2019
OI Cushman, Mary/0000-0002-7871-6143; Allison, Matthew/0000-0003-0777-8272
FU NHLBI NIH HHS [T32HL079891, N01-HC-95159, N01 HC095169, N01 HC095159,
   T32 HL079891] Funding Source: Medline
CR [Anonymous], 2008, DIABETES CARE, V31
   [Anonymous], 2000, DIAGN STAT MAN MENT
   Bild DE, 2002, AM J EPIDEMIOL, V156, P871, DOI 10.1093/aje/kwf113
   Breslau J, 2011, ARCH GEN PSYCHIAT, V68, P428, DOI 10.1001/archgenpsychiatry.2011.21
   Bruce ML, 2010, AM J GERIAT PSYCHIAT, V18, P189, DOI 10.1097/JGP.0b013e3181cb87f7
   Camacho A, 2013, MED HYPOTHESES, V81, P577, DOI 10.1016/j.mehy.2013.07.006
   Capuron L, 2008, BIOL PSYCHIAT, V64, P896, DOI 10.1016/j.biopsych.2008.05.019
   Cho HJ, 2009, BIOL PSYCHIAT, V66, P871, DOI 10.1016/j.biopsych.2009.06.008
   Danese A, 2008, ARCH GEN PSYCHIAT, V65, P409, DOI 10.1001/archpsyc.65.4.409
   Danner M, 2003, PSYCHOSOM MED, V65, P347, DOI 10.1097/01.PSY.0000041542.29808.01
   Delaney JAC, 2009, PHARMACOEPIDEM DR S, V18, P545, DOI 10.1002/pds.1751
   Dinan TG, 2009, CURR OPIN PSYCHIATR, V22, P32, DOI 10.1097/YCO.0b013e328315a561
   Fagundes CP, 2012, BRAIN BEHAV IMMUN
   Familiar I, 2011, J AFFECT DISORDERS, V130, P83, DOI 10.1016/j.jad.2010.09.025
   Gegenava T, 2011, Georgian Med News, P34
   González-Tejera G, 2005, J CHILD PSYCHOL PSYC, V46, P888, DOI 10.1111/j.1469-7610.2005.00370.x
   Greden John F., 2001, Journal of Clinical Psychiatry, V62, P26
   Hamer M., 2012, DIALOGUES CARDIOVASC, V17, P107
   Hauser W., 2013, COCHRANE DATABASE SY, V1
   Janszky I, 2005, BRAIN BEHAV IMMUN, V19, P555, DOI 10.1016/j.bbi.2005.01.001
   Judd LL, 2002, PSYCHIAT CLIN N AM, V25, P685, DOI 10.1016/S0193-953X(02)00026-6
   Kipper-Galperin M, 1999, INT J DEV NEUROSCI, V17, P765, DOI 10.1016/S0736-5748(99)00067-2
   Kop WJ, 2002, AM J CARDIOL, V89, P419, DOI 10.1016/S0002-9149(01)02264-0
   Lekander M, 2004, PSYCHOSOM MED, V66, P559, DOI 10.1097/01.psy.0000130491.95823.94
   Libby P, 1999, CIRCULATION, V100, P1148, DOI 10.1161/01.CIR.100.11.1148
   Liukkonen T, 2006, BIOL PSYCHIAT, V60, P825, DOI 10.1016/j.biopsych.2006.02.016
   Maes M, 2009, METAB BRAIN DIS, V24, P27, DOI 10.1007/s11011-008-9118-1
   Matthews KA, 2007, PSYCHOSOM MED, V69, P124, DOI 10.1097/01.psy.0000256574.30389.1b
   Miller AH, 2009, BIOL PSYCHIAT, V65, P732, DOI 10.1016/j.biopsych.2008.11.029
   Morris AA, 2011, PSYCHOSOM MED, V73, P462, DOI 10.1097/PSY.0b013e318222379c
   Musselman DL, 1998, ARCH GEN PSYCHIAT, V55, P580, DOI 10.1001/archpsyc.55.7.580
   Otte C, 2004, BIOL PSYCHIAT, V56, P241, DOI 10.1016/j.biopsych.2004.06.003
   Patton GC, 1998, AM J PUBLIC HEALTH, V88, P1518, DOI 10.2105/AJPH.88.10.1518
   Penninx BWJH, 2003, BIOL PSYCHIAT, V54, P566, DOI 10.1016/S0006-3223(02)01811-5
   PSATY BM, 1992, J CLIN EPIDEMIOL, V45, P683, DOI 10.1016/0895-4356(92)90143-B
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Ranjit N, 2007, ARCH INTERN MED, V167, P174, DOI 10.1001/archinte.167.2.174
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Roy B, 2010, PSYCHOSOM MED, V72, P134, DOI 10.1097/PSY.0b013e3181cb981b
   Schins A, 2005, J PSYCHIATR RES, V39, P137, DOI 10.1016/j.jpsychires.2004.05.009
   SPITZER RL, 1992, ARCH GEN PSYCHIAT, V49, P624
   Steptoe A, 2003, PSYCHOL MED, V33, P667, DOI 10.1017/S0033291702007250
   Sullivan MD, 2013, JAMA PSYCHIAT, V70, P1041, DOI 10.1001/jamapsychiatry.2013.1965
   Tiemeier H, 2003, EPIDEMIOLOGY, V14, P103, DOI 10.1097/00001648-200301000-00025
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
   Vahia IV, 2010, AM J GERIAT PSYCHIAT, V18, P212, DOI 10.1097/JGP.0b013e3181b7f10e
   VanItallie TB, 2005, METABOLISM, V54, P39, DOI 10.1016/j.metabol.2005.01.012
   Wassertheil-Smoller S, 2004, ARCH INTERN MED, V164, P289, DOI 10.1001/archinte.164.3.289
   Whooley MA, 2007, BIOL PSYCHIAT, V62, P314, DOI 10.1016/j.biopsych.2006.10.016
   Yaffe K, 2007, J AM GERIATR SOC, V55, P758, DOI 10.1111/j.1532-5415.2007.01139.x
   Zhang K., 2012, BRAIN RES
NR 51
TC 17
Z9 19
U1 0
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD AUG 1
PY 2014
VL 164
BP 165
EP 170
DI 10.1016/j.jad.2014.04.018
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA AH9BX
UT WOS:000336436000026
PM 24856570
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Tyagi, A
   Cohen, M
AF Tyagi, Anupama
   Cohen, Marc
TI Yoga and Hypertension: A Systematic Review
SO ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
LA English
DT Article
ID GUIDED BREATHING EXERCISES; AMBULATORY BLOOD-PRESSURE; TYPE-2
   DIABETES-MELLITUS; HEART-RATE-VARIABILITY; QUALITY-OF-LIFE;
   RISK-FACTORS; HATHA-YOGA; NONPHARMACOLOGIC TREATMENT;
   CARDIOVASCULAR-DISEASE; TREATING HYPERTENSION
AB Lifestyle modification is a cornerstone of hypertension (HPT) treatment, yet most recommendations currently focus on diet and exercise and do not consider stress reduction strategies. Yoga is a spiritual path that may reduce blood pressure (BP) through reducing stress, increasing parasympathetic activation, and altering baroreceptor sensitivity; however, despite reviews on yoga and cardiovascular disease, diabetes, metabolic syndrome, and anxiety that suggest yoga may reduce BP, no comprehensive review has yet focused on yoga and HPT. A systematic review of all published studies on yoga and HPT was performed revealing 39 cohort studies, 30 nonrandomized, controlled trials (NRCTs), 48 randomized, controlled trials (RCTs), and 3 case reports with durations ranging from 1 wk to 4 y and involving a total of 6693 subjects. Most studies reported that yoga effectively reduced BP in both normotensive and hypertensive populations. These studies suggest that yoga is an effective adjunct therapy for HPT and worthy of inclusion in clinical guidelines, yet the great heterogeneity of yoga practices and the variable quality of the research makes it difficult to recommend any specific yoga practice for HPT. Future research needs to focus on high quality clinical trials along with studies on the mechanisms of action of different yoga practices.
C1 [Tyagi, Anupama] RMIT Univ, Sch Hlth Sci, Bundoora, Vic, Australia.
   [Cohen, Marc] RMIT Univ, Sch Hlth Sci, Melbourne, Vic, Australia.
C3 Royal Melbourne Institute of Technology (RMIT); Royal Melbourne
   Institute of Technology (RMIT)
RP Cohen, M (corresponding author), RMIT Univ, Sch Hlth Sci, Melbourne, Vic, Australia.
EM marc.cohen@rmit.edu.au
RI Cohen, Marc/GWV-0933-2022
OI Cohen, Marc/0000-0002-5876-6565
CR Agte Vaishali V, 2011, Indian J Physiol Pharmacol, V55, P183
   Aljasir B, 2010, EVID-BASED COMPL ALT, V7, P399, DOI 10.1093/ecam/nen027
   Altena MR, 2009, BLOOD PRESSURE, V18, P273, DOI 10.1080/08037050903272925
   Anderson DE, 2010, J HUM HYPERTENS, V24, P807, DOI 10.1038/jhh.2010.18
   ANDREWS G, 1982, BMJ-BRIT MED J, V284, P1523, DOI 10.1136/bmj.284.6328.1523
   Anita Herur Anita Herur, 2010, Al Ameen Journal of Medical Sciences, V3, P337
   [Anonymous], BIOMEDICINE SCOPUS
   [Anonymous], CLIN RHEUMATOL
   [Anonymous], J ALTERN COMPLEME S1
   [Anonymous], 1984, Journal of Psychological Researches, DOI DOI 10.1080/15377903.2013.863259
   [Anonymous], J INDIAN PSYCHOL
   [Anonymous], INDIAN J OCCUP THERP
   [Anonymous], AVIATION MED
   [Anonymous], EVID BASED COMPLEMEN
   [Anonymous], 2011, EVID BASED COMPLEMEN
   [Anonymous], YOGA MIMAMSA
   [Anonymous], 2019, HYP AD DIAGN MAN
   [Anonymous], COCHRANE DATABASE SY
   [Anonymous], J EXERC PHYSL ONLINE
   [Anonymous], J INDIAN ACAD APPL P
   [Anonymous], BR J SPORTS MED
   [Anonymous], GUID MAN HYP DOCTR
   [Anonymous], INDIAN J PHYSL PHARM
   [Anonymous], J NUTR METAB
   [Anonymous], 2011, J Phys Educ Sport Manag
   [Anonymous], ASS PHYS IND CARD SO
   [Anonymous], EVID REP TECHNOL ASS
   [Anonymous], YOGA CARDIOVASCULAR
   [Anonymous], PREV CARDIOL
   [Anonymous], STRESS MANAG YOGA ME
   [Anonymous], MASTER GUIDE MEDIATI
   Bagga O P, 1983, Indian Heart J, V35, P39
   Barnes VA, 2008, ETHNIC DIS, V18, P1
   Bernardi L, 2001, J HYPERTENS, V19, P2221, DOI 10.1097/00004872-200112000-00016
   Bernardi L, 2001, BRIT MED J, V323, P1446, DOI 10.1136/bmj.323.7327.1446
   Bernardi L, 2007, EUR J APPL PHYSIOL, V99, P511, DOI 10.1007/s00421-006-0373-8
   BHARGAVA R, 1988, Indian Journal of Physiology and Pharmacology, V32, P257
   Bhavanani Ananda Balayogi, 2011, Int J Yoga Therap, P73
   Bhavanani Ananda Balayogi, 2003, Indian Journal of Physiology and Pharmacology, V47, P297
   Bowman AJ, 1997, EUR J CLIN INVEST, V27, P443, DOI 10.1046/j.1365-2362.1997.1340681.x
   BROWNSTEIN AH, 1989, AVIAT SPACE ENVIR MD, V60, P684
   Cade WT, 2010, HIV MED, V11, P379, DOI 10.1111/j.1468-1293.2009.00801.x
   Chaudhary A K, 1988, J Assoc Physicians India, V36, P721
   Chen KM, 2008, J CLIN NURS, V17, P2634, DOI 10.1111/j.1365-2702.2008.02338.x
   Chen Kuei-Min, 2008, J Nurs Res, V16, P37
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   Chung SC, 2012, J ALTERN COMPLEM MED, V18, P589, DOI 10.1089/acm.2011.0038
   Cohen Beth E., 2008, Metabolic Syndrome and Related Disorders, V6, P223, DOI 10.1089/met.2008.0016
   Cowen VS, 2005, J BODYW MOV THER, V9, P211, DOI 10.1016/j.jbmt.2004.08.001
   CUSUMANO JA, 1993, APPL PSYCHOL-INT REV, V42, P77, DOI 10.1111/j.1464-0597.1993.tb00725.x
   Damodaran A, 2002, J Assoc Physicians India, V50, P633
   DATEY K K, 1980, Journal of Postgraduate Medicine (Bombay), V26, P68
   DATEY KK, 1969, ANGIOLOGY, V20, P325, DOI 10.1177/000331976902000602
   Deepa T, 2012, J CLIN DIAGN RES, V6, P21
   Devi S K, 1986, Anc Sci Life, V6, P112
   Dickinson HO, 2006, J HYPERTENS, V24, P215, DOI 10.1097/01.hjh.0000199800.72563.26
   Dolgoff-Kaspar R, 2012, ALTERN THER HEALTH M, V18, P61
   Ebnezar John, 2011, Int J Yoga, V4, P55, DOI 10.4103/0973-6131.85486
   Elliot William J, 2004, J Clin Hypertens (Greenwich), V6, P553, DOI 10.1111/j.1524-6175.2004.03553.x
   Elliott William J, 2006, MedGenMed, V8, P23
   Gokal R, 2007, J ALTERN COMPLEM MED, V13, P1056, DOI 10.1089/acm.2007.0679
   Gopal Aravind, 2011, Int J Yoga, V4, P26, DOI 10.4103/0973-6131.78178
   Granath Jens, 2006, Cognitive Behaviour Therapy, V35, P3, DOI 10.1080/16506070500401292
   GREENBERG G, 1985, BMJ-BRIT MED J, V291, P97
   Gregoski MJ, 2011, J ADOLESCENT HEALTH, V48, P59, DOI 10.1016/j.jadohealth.2010.05.019
   Grossman E, 2001, J HUM HYPERTENS, V15, P263, DOI 10.1038/sj.jhh.1001147
   Guarracino J. L., 2006, Topics in Clinical Nutrition, V21, P108
   Gupta P.K., 2010, Journal of the Indian Academy of Applied Psychology, V36, P159
   Gupta R, 2010, INDIAN J MED RES, V132, P531
   Haaz S, 2011, RHEUM DIS CLIN N AM, V37, P33, DOI 10.1016/j.rdc.2010.11.001
   HABER D, 1983, INT J AGING HUM DEV, V17, P169, DOI 10.2190/HU5C-32FH-APVU-N6FY
   HAFNER RJ, 1982, BIOFEEDBACK SELF-REG, V7, P305, DOI 10.1007/BF00998923
   Harinath K, 2004, J ALTERN COMPLEM MED, V10, P261, DOI 10.1089/107555304323062257
   Hegde Shreelaxmi V, 2012, Complement Ther Clin Pract, V18, P151, DOI 10.1016/j.ctcp.2012.04.002
   Hegde SV, 2011, DIABETES CARE, V34, P2208, DOI 10.2337/dc10-2430
   Herur A, 2011, BIOMED RES-INDIA, V22, P499
   Hutchinson S., 2003, Focus on Alternative and Complementary Therapies, V8, P144
   Innes KE, 2005, J AM BOARD FAM PRACT, V18, P491, DOI 10.3122/jabfm.18.6.491
   Innes KE, 2007, EVID-BASED COMPL ALT, V4, P469, DOI 10.1093/ecam/nel103
   Innes KE, 2013, J ALTERN COMPLEM MED, V19, P527, DOI 10.1089/acm.2012.0330
   Jain Nidhi, 2005, Indian J Physiol Pharmacol, V49, P469
   Jain Sangeeta, 2010, Indian J Physiol Pharmacol, V54, P183
   Jaju Deepali S, 2011, Sultan Qaboos Univ Med J, V11, P221
   Javnbakht M, 2009, Complement Ther Clin Pract, V15, P102, DOI 10.1016/j.ctcp.2009.01.003
   Jayasinghe SR, 2004, EUR J CARDIOV PREV R, V11, P369, DOI 10.1097/00149831-200410000-00002
   JOSEPH S, 1981, INDIAN J MED RES, V74, P120
   Kaplan MS, 2003, NUTR METAB CARDIOVAS, V13, P52, DOI 10.1016/S0939-4753(03)80168-0
   Karunagari K., 2007, SINGAPORE NURSING J, V34, P47
   Kaushik RM, 2006, COMPLEMENT THER MED, V14, P120, DOI 10.1016/j.ctim.2005.11.007
   Kearney PM, 2005, LANCET, V365, P217, DOI 10.1016/S0140-6736(05)70151-3
   Kelly Z., 2009, International Association of Yoga Therapists, V19, P103
   Khalsa SBS, 2004, APPL PSYCHOPHYS BIOF, V29, P269, DOI 10.1007/s10484-004-0387-0
   Khatri Deepali, 2007, Diabetes Res Clin Pract, V78, pe9, DOI 10.1016/j.diabres.2007.05.002
   Kim S, 2012, J SPORT SCI MED, V11, P322
   Kirkwood G, 2005, BRIT J SPORT MED, V39, P884, DOI 10.1136/bjsm.2005.018069
   Konar Debbindu, 2000, Indian Journal of Physiology and Pharmacology, V44, P392
   Lakshmikanthan C, 1979, J Assoc Physicians India, V27, P1055
   Latha, 1991, Journal of Indian Psychology, V9, P36
   Lee JA, 2012, MENOPAUSE, V19, P296, DOI 10.1097/gme.0b013e31822d59a2
   Lee MS, 2009, MENOPAUSE, V16, P602, DOI 10.1097/gme.0b013e31818ffe39
   Lewington S, 2002, LANCET, V360, P1903, DOI 10.1016/S0140-6736(02)11911-8
   Logtenberg SJ, 2007, J HYPERTENS, V25, P241, DOI 10.1097/HJH.0b013e32801040d5
   Madanmohan, 2005, Indian Journal of Physiology and Pharmacology, V49, P313
   Madanmohan, 2004, Indian Journal of Physiology and Pharmacology, V48, P461
   Madanmohan, 2002, Indian Journal of Physiology and Pharmacology, V46, P307
   Madanmohan, 2004, Indian J Physiol Pharmacol, V48, P370
   Madanmohan, 2008, Indian J Physiol Pharmacol, V52, P164
   Mancia G, 2007, EUR HEART J, V28, P1462, DOI 10.1093/eurheartj/ehm236
   McCaffrey Ruth, 2005, Holist Nurs Pract, V19, P173
   Mehta P, 2010, J EVID-BASED INTEGR, V15, P156, DOI 10.1177/1533210110387405
   Meles E, 2004, AM J HYPERTENS, V17, P370, DOI 10.1016/j.amjhyper.2003.12.009
   Modesti PA, 2010, J HYPERTENS, V28, P1097, DOI 10.1097/HJH.0b013e3283362762
   Moseley JV, 2006, PSYCHOSOM MED, V68, P833, DOI 10.1097/01.psy.0000238453.11324.d5
   Mourya M, 2009, J ALTERN COMPLEM MED, V15, P711, DOI 10.1089/acm.2008.0609
   Murthy Niranjan Murthy Niranjan, 2009, Journal of Chinese Clinical Medicine, V4, P139
   Murthy S N, 2011, Complement Ther Clin Pract, V17, P9, DOI 10.1016/j.ctcp.2010.08.005
   Murugesan R., 2000, Indian Journal of Physiology and Pharmacology, V44, P207
   NAGARATHNA R, 1985, BMJ-BRIT MED J, V291, P1077, DOI 10.1136/bmj.291.6502.1077
   Narkiewicz K, 2006, HYPERTENSION, V47, P51, DOI 10.1161/01.HYP.0000197613.47649.02
   Okonta NR, 2012, HOLIST NURS PRACT, V26, P137, DOI 10.1097/HNP.0b013e31824ef647
   Pal A, 2011, COMPLEMENT THER MED, V19, P122, DOI 10.1016/j.ctim.2011.05.001
   Pandic S., 2008, CVD PREVENTION CONTR, V3, P163
   Parshad O, 2011, W INDIAN MED J, V60, P148
   Patel C, 1976, J R Coll Gen Pract, V26, P211
   Patel C, 1977, J R Coll Gen Pract, V27, P401
   PATEL C, 1976, ANGIOLOGY, V27, P106, DOI 10.1177/000331977602700204
   PATEL C, 1981, BMJ-BRIT MED J, V282, P2005, DOI 10.1136/bmj.282.6281.2005
   PATEL C, 1975, LANCET, V1, P62
   PATEL C, 1975, LANCET, V2, P93
   PATEL C, 1988, BMJ-BRIT MED J, V296, P21, DOI 10.1136/bmj.296.6614.21
   PATEL C, 1985, BMJ-BRIT MED J, V290, P1103, DOI 10.1136/bmj.290.6475.1103
   PATEL CH, 1973, LANCET, V2, P1053
   Posadzki P, 2011, J ASTHMA, V48, P632, DOI 10.3109/02770903.2011.584358
   Rabi DM, 2011, CAN J CARDIOL, V27, P415, DOI 10.1016/j.cjca.2011.03.015
   Rainforth MV, 2007, CURR HYPERTENS REP, V9, P520, DOI 10.1007/s11906-007-0094-3
   RAJU PS, 1994, INDIAN J MED RES, V100, P81
   Ramos-Jimenez Arnulfo, 2009, Int J Yoga, V2, P49, DOI 10.4103/0973-6131.60044
   RAPPAPORT AF, 1977, BEHAV THER, V8, P269, DOI 10.1016/S0005-7894(77)80279-7
   Ray U. S., 2001, Indian Journal of Physiology and Pharmacology, V45, P37
   Rosenthal T, 2001, AM J HYPERTENS, V14, P74, DOI 10.1016/S0895-7061(00)01235-8
   SACHDEVA U, 1994, HOMEOSTASIS HLTH DIS, V35, P264
   Saptharishi Lg, 2009, Indian J Community Med, V34, P329, DOI 10.4103/0970-0218.58393
   SATYANARAYANA M, 1992, Indian Journal of Physiology and Pharmacology, V36, P88
   Saxena Tarun, 2009, Int J Yoga, V2, P22, DOI 10.4103/0973-6131.53838
   Schein MH, 2009, J HUM HYPERTENS, V23, P325, DOI 10.1038/jhh.2008.135
   Schein MH, 2001, J HUM HYPERTENS, V15, P271, DOI 10.1038/sj.jhh.1001148
   Schmidt T, 1997, ACTA PHYSIOL SCAND, V161, P158
   Selvamurthy W., 1998, Indian Journal of Physiology and Pharmacology, V42, P205
   Shankardevananda S, 2014, The Effects of Yoga on Hypertension
   Sharma G, 2007, J BODYW MOV THER, V11, P173, DOI 10.1016/j.jbmt.2007.01.002
   Sharma M, 2012, J EVID-BASED INTEGR, V17, P199, DOI 10.1177/2156587212452144
   Singh Savita, 2004, J Assoc Physicians India, V52, P203
   Singh Vijay Kumar, 2011, Indian J Physiol Pharmacol, V55, P329
   Sivasankaran S, 2006, CLIN CARDIOL, V29, P393, DOI 10.1002/clc.4960290905
   Skoro-Kondza L, 2009, BMC HEALTH SERV RES, V9, DOI 10.1186/1472-6963-9-33
   Smith C, 2007, COMPLEMENT THER MED, V15, P77, DOI 10.1016/j.ctim.2006.05.001
   Smith KB, 2009, PSYCHO-ONCOLOGY, V18, P465, DOI 10.1002/pon.1411
   Srivastava R D, 2005, Indian J Physiol Pharmacol, V49, P475
   Subbalakshmi NK., 2005, Thai J Physiol Sci, V18, P10
   SUNDAR S, 1984, ACTA CARDIOL, V39, P203
   Talukdar B, 1996, Indian J Clin Biochem, V11, P129, DOI [/10.1007/BF02896430, DOI 10.1007/BF02896430]
   Taylor AG, 2010, EXPLORE-NY, V6, P29, DOI 10.1016/j.explore.2009.10.004
   Telles S, 1993, Indian J Med Sci, V47, P235
   Thomley BS, 2011, EXPLORE-NY, V7, P27, DOI 10.1016/j.explore.2010.10.004
   Tracy BL, 2013, J STRENGTH COND RES, V27, P822, DOI 10.1519/JSC.0b013e31825c340f
   Udupa K.N., 1985, STRESS ITS MANAGEMEN
   Udupa Kaviraja, 2003, Indian J Physiol Pharmacol, V47, P27
   UDUPA KN, 1975, INDIAN J MED RES, V63, P1062
   UDUPA KN, 1975, INDIAN J MED RES, V63, P620
   Uebelacker LA, 2010, J PSYCHIATR PRACT, V16, P22, DOI 10.1097/01.pra.0000367775.88388.96
   Upadhyay Dhungel K, 2008, Nepal Med Coll J, V10, P25
   Vaishali V.A., 2008, ALTERN COMPLEMENT TH, V14, P96, DOI [DOI 10.1089/act.2008.14204, 10.1089/act.2008.14204]
   VANMONTFRANS GA, 1990, BRIT MED J, V300, P1368, DOI 10.1136/bmj.300.6736.1368
   Veerabhadrappa Shashikala G, 2011, J Cardiovasc Dis Res, V2, P223, DOI 10.4103/0975-3583.89806
   Vijayalakshmi P., 2004, Indian Journal of Physiology and Pharmacology, V48, P59
   Viskoper R, 2003, AM J HYPERTENS, V16, P484, DOI 10.1016/S0895-7061(03)00571-5
   Vogler Juliane, 2011, Int J Yoga Therap, P61
   Wang SZ, 2010, J ALTERN COMPLEM MED, V16, P1039, DOI 10.1089/acm.2009.0577
   Whelton PK, 2002, JAMA-J AM MED ASSOC, V288, P1882, DOI 10.1001/jama.288.15.1882
   Williams B, 2004, J HUM HYPERTENS, V18, P139, DOI 10.1038/sj.jhh.1001683
   World Health Organization, 2024, Promoting Wellbeing.
   World Health Organization (WHO), 2007, Prevention of cardiovascular disease
   Yang K, 2007, EVID-BASED COMPL ALT, V4, P487, DOI 10.1093/ecam/nem154
NR 183
TC 41
Z9 50
U1 0
U2 24
PU InnoVision Professional Media
PI Eagan
PA 3470 Washington Drive Suite 102, Eagan, MN 55122, UNITED STATES
SN 1078-6791
J9 ALTERN THER HEALTH M
JI Altern. Ther. Health Med.
PD MAR-APR
PY 2014
VL 20
IS 2
BP 32
EP 59
PG 28
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA AZ2YD
UT WOS:000348094300005
PM 24657958
DA 2025-06-11
ER

PT J
AU Bjoernsdottir, S
   Ulfsdottir, H
   Gudmundsson, EF
   Sveinsdottir, K
   Isberg, AP
   Dobies, B
   Magnusdottir, GEA
   Gunnarsdottir, T
   Karlsdottir, T
   Bjornsdottir, G
   Sigurdsson, S
   Oddsson, S
   Gudnason, V
AF Bjoernsdottir, Sigridur
   Ulfsdottir, Hildigunnur
   Gudmundsson, Elias Freyr
   Sveinsdottir, Kolbrun
   Isberg, Ari Pall
   Dobies, Bartosz
   Magnusdottir, Gudlaug Erla Akerlie
   Gunnarsdottir, Thrudur
   Karlsdottir, Tekla
   Bjornsdottir, Gudlaug
   Sigurdsson, Sigurdur
   Oddsson, Saemundur
   Gudnason, Vilmundur
TI User Engagement, Acceptability, and Clinical Markers in a Digital Health
   Program for Nonalcoholic Fatty Liver Disease: Prospective, Single-Arm
   Feasibility Study
SO JMIR CARDIO
LA English
DT Article
DE digital health program; nonalcoholic fatty liver disease; NAFLD;
   cardiometabolic health; digital therapeutics; liver; chronic; hepatic;
   cardiometabolic; cardiovascular; cardiology; weight; acceptability;
   digital health; metabolic syndrome; diabetic; diabetes; diabetics; type
   2; BMI; lifestyle; exercise; physical activity; coaching; diet; dietary;
   nutrition; nutritional; patient education; coach; feasibility; fat; body
   composition
ID WEIGHT-LOSS; LIFE-STYLE; ASSOCIATION; STEATOSIS; NAFLD; RISK
AB Background: Nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in the world. Common comorbidities are central obesity, type 2 diabetes mellitus, dyslipidemia, and metabolic syndrome. Cardiovascular disease is the most common cause of death among people with NAFLD, and lifestyle changes can improve health outcomes. Objective: This study aims to explore the acceptability of a digital health program in terms of engagement, retention, and user satisfaction in addition to exploring changes in clinical outcomes, such as weight, cardiometabolic risk factors, and health-related quality of life. Methods: We conducted a prospective, open-label, single-arm, 12-week study including 38 individuals with either a BMI >30, metabolic syndrome, or type 2 diabetes mellitus and NAFLD screened by FibroScan. An NAFLD-specific digital health program focused on disease education, lowering carbohydrates in the diet, food logging, increasing activity level, reducing stress, and healthy lifestyle coaching was offered to participants. The coach provided weekly feedback on food logs and other in-app activities and opportunities for participants to ask questions. The coaching was active throughout the 12-week intervention period. The primary outcome was feasibility and acceptability of the 12-week program, assessed through patient engagement, retention, and satisfaction with the program. Secondary outcomes included changes in weight, liver fat, body composition, and other cardiometabolic clinical parameters at baseline and 12 weeks. Results: In total, 38 individuals were included in the study (median age 59.5, IQR 46.3-68.8 years; n=23, 61% female). Overall, 34 (89%) participants completed the program and 29 (76%) were active during the 12-week program period. The median satisfaction score was 6.3 (IQR 5.8-6.7) of 7. Mean weight loss was 3.5 (SD 3.7) kg (P<.001) or 3.2% (SD 3.4%), with a 2.2 (SD 2.7) kg reduction in fat mass (P<.001). Relative liver fat reduction was 19.4% (SD 23.9%). Systolic blood pressure was reduced by 6.0 (SD 13.5) mmHg (P=.009). The median reduction was 0.14 (IQR 0-0.47) mmol/L for triglyceride levels (P=.003), 3.2 (IQR 0.0-5.4) mu U/ml for serum insulin (s-insulin) levels (P=.003), and 0.5 (IQR -0.7 to 3.8) mmol/mol for hemoglobin A(1c) (HbA(1c)) levels (P=.03). Participants who were highly engaged (ie, who used the app at least 5 days per week) had greater weight loss and liver fat reduction. Conclusions: The 12-week-long digital health program was feasible for individuals with NAFLD, receiving high user engagement, retention, and satisfaction. Improved liver-specific and cardiometabolic health was observed, and more engaged participants showed greater improvements. This digital health program could provide a new tool to improve health outcomes in people with NAFLD.
C1 [Bjoernsdottir, Sigridur] Karolinska Inst, Dept Endocrinol Metab & Diabet, Solnavagen 1, S-17177 Stockholm, Sweden.
   [Ulfsdottir, Hildigunnur; Gudmundsson, Elias Freyr; Sveinsdottir, Kolbrun; Isberg, Ari Pall; Dobies, Bartosz; Magnusdottir, Gudlaug Erla Akerlie; Gunnarsdottir, Thrudur; Oddsson, Saemundur] Sidekick Hlth, Kopavogur, Iceland.
   [Bjornsdottir, Gudlaug; Sigurdsson, Sigurdur; Gudnason, Vilmundur] Iceland Heart Assoc, Kopavogur, Iceland.
   [Bjornsdottir, Gudlaug; Sigurdsson, Sigurdur; Gudnason, Vilmundur] Univ Iceland, Fac Med, Sch Hlth Sci, Reykjavik, Iceland.
C3 Karolinska Institutet; Icelandic Heart Association; University of
   Iceland
RP Bjoernsdottir, S (corresponding author), Karolinska Inst, Dept Endocrinol Metab & Diabet, Solnavagen 1, S-17177 Stockholm, Sweden.
EM sigridur.bjornsdottir@ki.se
RI Gudnason, Vilmundur/AAE-7126-2019
OI Bjornsdottir, Sigridur/0000-0002-3320-5972; Ulfsdottir,
   Hildigunnur/0009-0004-0301-7710; , Bartosz Dobies/0009-0000-8851-3692;
   Isberg, Ari Pall/0000-0002-7957-6285; Gudmundsson, Elias
   Freyr/0000-0002-7661-4872; Akerlie Magnusdottir, Gudlaug
   Erla/0009-0002-8441-0017; Sveinsdottir, Kolbrun/0009-0001-3148-5210
CR Amagai S, 2022, J MED INTERNET RES, V24, DOI 10.2196/35120
   Andersen K, 2022, LAEKNABLADID, V108, P346, DOI 10.17992/lbl.2022.0708.701
   Berlowitz DR, 2017, NEW ENGL J MED, V377, P733, DOI 10.1056/NEJMoa1611179
   Berzigotti A, 2021, J HEPATOL, V75, P659, DOI 10.1016/j.jhep.2021.05.025
   Bress AP, 2017, NEW ENGL J MED, V377, P745, DOI 10.1056/NEJMsa1616035
   Budd J, 2020, AM J MED, V133, P536, DOI 10.1016/j.amjmed.2020.01.007
   Byrne CD, 2020, J HEPATOL, V72, P785, DOI 10.1016/j.jhep.2020.01.013
   Caussy C, 2018, HEPATOLOGY, V68, P763, DOI 10.1002/hep.29797
   Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI 10.1002/hep.29367
   Cusi K, 2022, ENDOCR PRACT, V28, P528, DOI 10.1016/j.eprac.2022.03.010
   EASL, 2016, OBESITY FACTS, V9, P65, DOI [10.1159/000443344, 10.1007/s00125-016-3902-y, 10.1016/j.jhep.2015.11.004]
   Eddowes PJ, 2019, GASTROENTEROLOGY, V156, P1717, DOI 10.1053/j.gastro.2019.01.042
   El Khoury CF, 2019, J ACAD NUTR DIET, V119, P626, DOI 10.1016/j.jand.2018.11.010
   Fernando DH, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20205037
   Ferraioli G, 2021, J MED ULTRASON, V48, P489, DOI 10.1007/s10396-021-01106-1
   França M, 2017, ABDOM RADIOL, V42, P1434, DOI 10.1007/s00261-017-1048-0
   Friedman SL, 2018, NAT MED, V24, P908, DOI 10.1038/s41591-018-0104-9
   Frohme J, 2020, HEPATOBIL SURG NUTR, V9, P543, DOI 10.21037/hbsn.2020.03.03
   Galiero R, 2021, REV CARDIOVASC MED, V22, P755, DOI 10.31083/j.rcm2203082
   Godoy-Matos AF, 2020, DIABETOL METAB SYNDR, V12, DOI 10.1186/s13098-020-00570-y
   Hardy OT, 2012, CURR OPIN ENDOCRINOL, V19, P81, DOI 10.1097/MED.0b013e3283514e13
   Hull H, 2009, J CLIN DENSITOM, V12, P95, DOI 10.1016/j.jocd.2008.09.004
   Jiandani Dishay, 2016, BMC Obes, V3, P14, DOI 10.1186/s40608-016-0098-0
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Kneeman JM, 2012, THER ADV GASTROENTER, V5, P199, DOI 10.1177/1756283X11430859
   Lim SL, 2020, JMIR MHEALTH UHEALTH, V8, DOI 10.2196/14802
   Loomba R, 2020, HEPATOLOGY, V72, P1219, DOI 10.1002/hep.31121
   Mantovani A, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22052350
   Mazzotti A, 2018, J HEPATOL, V69, P1155, DOI 10.1016/j.jhep.2018.07.013
   Mohr DC, 2011, J MED INTERNET RES, V13, DOI 10.2196/jmir.1602
   Morisky DE, 2008, J CLIN HYPERTENS, V10, P348, DOI 10.1111/j.1751-7176.2008.07572.x
   Moroshko I, 2011, OBES REV, V12, P912, DOI 10.1111/j.1467-789X.2011.00915.x
   Polyzos SA, 2019, METABOLISM, V92, P82, DOI 10.1016/j.metabol.2018.11.014
   Pratap A, 2020, NPJ DIGIT MED, V3, DOI 10.1038/s41746-020-0224-8
   Rinella ME, 2015, JAMA-J AM MED ASSOC, V313, P2263, DOI 10.1001/jama.2015.5370
   Sanyal AJ, 2019, NAT REV GASTRO HEPAT, V16, P377, DOI 10.1038/s41575-019-0144-8
   Stine JG, 2021, CLIN GASTROENTEROL H, V19, P2274, DOI 10.1016/j.cgh.2020.08.061
   Sumida Y, 2021, LIFE-BASEL, V11, DOI 10.3390/life11020143
   Svansdottir E, 2013, EUR J PREV CARDIOL, V20, P322, DOI 10.1177/2047487312441723
   Targher G, 2020, GUT, V69, P1691, DOI 10.1136/gutjnl-2020-320622
   Vilar-Gomez E, 2015, GASTROENTEROLOGY, V149, P367, DOI 10.1053/j.gastro.2015.04.005
   Younossi ZM, 2019, J HEPATOL, V71, P793, DOI 10.1016/j.jhep.2019.06.021
   Younossi ZM, 2019, HEPATOLOGY, V69, P564, DOI 10.1002/hep.30254
   Younossi ZM, 2017, CLIN GASTROENTEROL H, V15, P1144, DOI 10.1016/j.cgh.2017.05.029
   Younossi ZM, 2016, HEPATOLOGY, V64, P1577, DOI 10.1002/hep.28785
   Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431
   Zatterale F, 2020, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.01607
   Zhang XR, 2020, CLIN MOL HEPATOL, V26, P128, DOI 10.3350/cmh.2019.0001n
   Zhou LM, 2019, JMIR MHEALTH UHEALTH, V7, DOI 10.2196/11500
NR 49
TC 0
Z9 0
U1 1
U2 4
PU JMIR PUBLICATIONS, INC
PI TORONTO
PA 130 QUEENS QUAY East, Unit 1100, TORONTO, ON M5A 0P6, CANADA
EI 2561-1011
J9 JMIR CARDIO
JI JMIR Cardio
PY 2024
VL 8
AR e52576
DI 10.2196/52576
PG 15
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA W3Y4Y
UT WOS:001417972500001
PM 38152892
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Pirmoradi, MR
   Asgharzadeh, A
   Birashk, B
   Gharraee, B
   Salehian, R
   Ostadrahimi, AR
AF Pirmoradi, Mohammad Reza
   Asgharzadeh, Ali
   Birashk, Behrooz
   Gharraee, Banafsheh
   Salehian, Razieh
   Ostadrahimi, Ali Reza
TI Acceptance, Mindfulness, and Compassionate-Based Intervention in
   Overweight and Obese Women and its Effect on Metabolic Syndrome
   Components: A Randomized Controlled Trial
SO CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES
LA English
DT Article
DE Overweight; Obesity; Acceptance; Mindfulness; Self-compassion;
   Randomized controlled trial
ID QUALITY-OF-LIFE; BODY-IMAGE; SYMPTOMS; ANXIETY; STYLES
AB Objectives: This study aimed to examine the efficacy of acceptance, mindfulness, and compassion (Kg-free) on obese and overweight women diagnosed with metabolic syndrome components. Materials and Methods: In this randomized controlled trial, 52 obese and overweight women with body mass index (BMI) >= 25 were evaluated in two intervention and control groups, The intervention was implemented weekly. Triglyceride (TG), high-density lipoprotein (HDL), fasting blood sugar (FBS), blood pressure (BP), BMI, and waistline measurements thyroid tests were assessed measured as the main outcome, and life-quality and sexual function improvement as its secondary outcome in pre, post and follow-up phase. Results: The study results indicated that the acceptance, mindfulness, and compassion (Kg-free) protocol was effective on the BMI, waistline, TG level, BP (systolic and diastolic index), quality of life, and sexual function in women with overweight and obesity, but fasting BP and HDL level did not significant (d=0.001-0.50; significant at the 0.001 level). Conclusions: The present trial was carried out aiming to examine the efficacy of group intervention based on acceptance, mindfulness, and compassion on obese and overweighed women and its effect on the components of metabolic syndrome, including the waistline, BMI, BP, FBS, TG, HDL, the quality of life, and the sexual function. Our results showed that group intervention based on acceptance, mindfulness, and compassion could reduce the BMI of the individuals in the intervention group compared to the control group. Moreover, the present study provided further evidence that this intervention bears an essential part in the psychological interventions for individuals struggling with overweight and obesity.
C1 [Pirmoradi, Mohammad Reza; Asgharzadeh, Ali; Birashk, Behrooz; Gharraee, Banafsheh] Iran Univ Med Sci, Tehran Inst Psychiat, Sch Behav Sci & Mental Hlth, Tehran, Iran.
   [Salehian, Razieh] Iran Univ Med Sci, Rasoul E Akram Hosp, Sch Med, Dept Psychiat, Tehran, Iran.
   [Ostadrahimi, Ali Reza] Tabriz Univ Med Sci, Nutr Res Ctr, Tabriz, Iran.
C3 Iran University of Medical Sciences; Iran University of Medical
   Sciences; Tabriz University of Medical Science
RP Asgharzadeh, A (corresponding author), Iran Univ Med Sci, Tehran Inst Psychiat, Sch Behav Sci & Mental Hlth, Tehran, Iran.
EM ali.asgharzadeh72@gmail.com
RI Gharraee, Banafsheh/O-2535-2018; Salehian, Razieh/B-2043-2019
CR Amini M, 2007, J Res Med Sci, V12, P315
   [Anonymous], 1996, WHOQOL BREF
   Baer RA, 2006, ASSESSMENT, V13, P27, DOI 10.1177/1073191105283504
   Bidadian M, 2013, Quarterly Journal of Health Psychology, V2, P22
   Cappelleri JC, 2009, INT J OBESITY, V33, P611, DOI 10.1038/ijo.2009.74
   Cash TF, 2002, INT J EAT DISORDER, V31, P455, DOI 10.1002/eat.10033
   Daubenmier J, 2016, OBESITY, V24, P794, DOI 10.1002/oby.21396
   Duarte C, 2015, CLIN PSYCHOL PSYCHOT, V22, P656, DOI 10.1002/cpp.1925
   Ebrahimi A, 2017, Journal of Thought & Behavior in Clinical Psychology, V11, P27
   Ebrahimi A, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.707291
   Ebrahimi A, 2021, FRONT PSYCHOL, V12, DOI 10.3389/fpsyg.2021.664736
   Ebrahimi A, 2017, IRAN J PSYCHIAT CLIN, V23, P278, DOI 10.29252/nirp.ijpcp.23.3.278
   Fallahi E, 2006, Med J Tabriz Univ Med Sci Health Serv, V28, P85
   Gilbert J., 2014, Journal of Compassionate Health Care, V1, P9, DOI DOI 10.1186/S40639-014-0009-5
   Gilbert P, 2004, BRIT J CLIN PSYCHOL, V43, P31, DOI 10.1348/014466504772812959
   Grundy SM, 2016, TRENDS CARDIOVAS MED, V26, P364, DOI 10.1016/j.tcm.2015.10.004
   Hayes S.C., 2008, International Journal of Behavior Consultation and Therapy, V4, P30, DOI DOI 10.1037/H0100865
   Heydarinasab L., 2013, INT J BEHAV SCI, V7, P229
   Hilbert A, 2015, OBESITY FACTS, V8, P293, DOI 10.1159/000438681
   García-Mendizábal MJ, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-120
   Kearney DJ, 2011, ALIMENT PHARM THER, V34, P363, DOI 10.1111/j.1365-2036.2011.04731.x
   Kelly AC, 2013, BRIT J CLIN PSYCHOL, V52, P148, DOI 10.1111/bjc.12006
   Kofman MD, 2010, OBESITY, V18, P1938, DOI 10.1038/oby.2010.27
   Kristeller Jean L, 2011, Eat Disord, V19, P49, DOI 10.1080/10640266.2011.533605
   Lee TM, 2017, thesis, DOI [10.13023/etd.2017.054, DOI 10.13023/ETD.2017.054]
   Marchiori D, 2014, APPETITE, V75, P40, DOI 10.1016/j.appet.2013.12.009
   Mohammadi K, 2008, Payesh, V7, P269
   Motallebi A, 2021, ASEAN Journal Psychiatry, V22, P1
   Muennig P, 2006, AM J PUBLIC HEALTH, V96, P1662, DOI 10.2105/AJPH.2005.068874
   Neff KD, 2003, SELF IDENTITY, V2, P223, DOI 10.1080/15298860390209035
   Nejat S., 2006, J SCH PUBLIC HLTH I, V4, P1, DOI DOI 10.1007/S00038-010-0174-Z
   O'Reilly GA, 2014, OBES REV, V15, P453, DOI 10.1111/obr.12156
   Ouwens MA, 2015, APPETITE, V87, P62, DOI 10.1016/j.appet.2014.11.030
   Palmeira L, 2017, APPETITE, V112, P107, DOI 10.1016/j.appet.2017.01.027
   Palmeira L, 2016, J CONTEXT BEHAV SCI, V5, P193, DOI 10.1016/j.jcbs.2016.06.001
   Pinto-Gouveia J, 2017, CLIN PSYCHOL PSYCHOT, V24, P1090, DOI 10.1002/cpp.2072
   Rajabi GR., 2011, RES CLIN PSYCHOL COU, V1, P171, DOI [10.1016/j.cpr.2021.102088, DOI 10.22067/IJAP.V1I2.9837]
   Riener Raphaela, 2006, Eat Behav, V7, P309, DOI 10.1016/j.eatbeh.2005.11.004
   Rosenzweig S, 2007, ALTERN THER HEALTH M, V13, P36
   Salmoirago-Blotcher E, 2015, CONTEMP CLIN TRIALS, V41, P248, DOI 10.1016/j.cct.2015.02.004
   Stefan N, 2020, NAT REV ENDOCRINOL, V16, P341, DOI 10.1038/s41574-020-0364-6
   World Health Organization, 2011, Waist circumference and waist-hip ratio: report of a WHO expert consultation
NR 42
TC 1
Z9 1
U1 3
U2 3
PU ARAS PART MEDICAL INT PRESS
PI TABRIZ
PA NO 1, S SHAREATI ST, 5138815941, TABRIZ, 00000, IRAN
SN 2148-9696
J9 CRESCENT J MED BIOL
JI Crescent J. Med. Biol. Sci.
PD OCT
PY 2024
VL 11
IS 4
BP 195
EP 206
DI 10.34172/cjmb.2023.25
PG 12
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA K8M5R
UT WOS:001346382400006
DA 2025-06-11
ER

PT J
AU Straub, RH
AF Straub, Rainer H.
TI Insulin resistance, selfish brain, and selfish immune system: an
   evolutionarily positively selected program used in chronic inflammatory
   diseases
SO ARTHRITIS RESEARCH & THERAPY
LA English
DT Review
ID BETA-CELL FUNCTION; OBESITY-RELATED HYPERTENSION; ACTIVE
   RHEUMATOID-ARTHRITIS; NECROSIS-FACTOR-ALPHA; METABOLIC SYNDROME;
   GLUCOSE-METABOLISM; MENTAL STRESS; JOB STRAIN; INFLIXIMAB TREATMENT;
   DIABETES-MELLITUS
AB Insulin resistance (IR) is a general phenomenon of many physiological states, disease states, and diseases. IR has been described in diabetes mellitus, obesity, infection, sepsis, trauma, painful states such as postoperative pain and migraine, schizophrenia, major depression, chronic mental stress, and others. In arthritis, abnormalities of glucose homeostasis were described in 1920; and in 1950 combined glucose and insulin tests unmistakably demonstrated IR. The phenomenon is now described in rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, polymyalgia rheumatica, and others. In chronic inflammatory diseases, cytokine-neutralizing strategies normalize insulin sensitivity. This paper delineates that IR is either based on inflammatory factors (activation of the immune/repair system) or on the brain (mental activation via stress axes). Due to the selfishness of the immune system and the selfishness of the brain, both can induce IR independent of each other. Consequently, the immune system can block the brain (for example, by sickness behavior)and the brain can block the immune system (for example, stress-induced immune system alterations). Based on considerations of evolutionary medicine, it is discussed that obesity per se is not a disease. Obesity-related IR depends on provoking factors from either the immune system or the brain. Chronic inflammation and/or stress axis activation are thus needed for obesity-related IR. Due to redundant pathways in stimulating IR, a simple one factor-neutralizing strategy might help in chronic inflammatory diseases (inflammation is the key), but not in obesity-related IR. The new considerations towards IR are interrelated to the published theories of IR (thrifty genotype, thrifty phenotype, and others).
C1 Univ Hosp, Dept Internal Med, Div Rheumatol, Lab Expt Rheumatol & Neuroendocrine Immunol, D-93042 Regensburg, Germany.
C3 University of Regensburg
RP Straub, RH (corresponding author), Univ Hosp, Dept Internal Med, Div Rheumatol, Lab Expt Rheumatol & Neuroendocrine Immunol, D-93042 Regensburg, Germany.
EM rainer.straub@ukr.de
OI Straub, Rainer H/0000-0003-1165-4555
FU Horizon Pharma Inc.
FX This supplement was proposed, developed and commissioned by Arthritis
   Research & Therapy and was funded by an educational grant from Horizon
   Pharma Inc. All published articles were independently prepared by the
   authors and have undergone peer review in accordance with the journal's
   standard policies and processes. Horizon Pharma Inc had no input into
   the topics covered or the articles themselves. The Supplement Editor was
   appointed by the journal and declares that they have no competing
   interests.
CR Abdul-Ghani MA, 2007, DIABETES CARE, V30, P89, DOI 10.2337/dc06-1519
   Agardh EE, 2003, DIABETES CARE, V26, P719, DOI 10.2337/diacare.26.3.719
   Aggarwal B, 2009, J GEN INTERN MED, V24, P93, DOI 10.1007/s11606-008-0852-1
   Aletaha D, 2010, ARTHRITIS RHEUM-US, V62, P2569, DOI 10.1002/art.27584
   ARENDT EC, 1956, J CLIN ENDOCR METAB, V16, P367, DOI 10.1210/jcem-16-3-367
   BERGMAN RN, 1979, AM J PHYSIOL, V236, pE667, DOI 10.1152/ajpendo.1979.236.6.E667
   Björntorp P, 2001, LANCET, V358, P1006, DOI 10.1016/S0140-6736(01)06110-4
   Björntorp P, 1999, DIABETES-METAB RES, V15, P427
   Blaxter KL., 1989, ENERGY METABOLISM AN
   Block JP, 2009, AM J EPIDEMIOL, V170, P181, DOI 10.1093/aje/kwp104
   Borai A, 2011, BMC MED RES METHODOL, V11, DOI 10.1186/1471-2288-11-158
   Borella P, 1999, PSYCHONEUROENDOCRINO, V24, P613, DOI 10.1016/S0306-4530(99)00016-5
   Boyer D, 2010, PHILOS T R SOC A, V368, P5645, DOI 10.1098/rsta.2010.0275
   Brunner EJ, 2007, AM J EPIDEMIOL, V165, P828, DOI 10.1093/aje/kwk058
   Butterfield W. J. H., 1965, Diabetologia, V1, P43, DOI 10.1007/BF01338715
   CAHILL GF, 1979, METABOLISM, V28, P389, DOI 10.1016/0026-0495(79)90043-X
   Calder PC, 2007, CURR OPIN CLIN NUTR, V10, P531, DOI 10.1097/MCO.0b013e3281e72ad4
   Capellino S, 2014, ANN NY ACAD SCI, V1317, P24, DOI 10.1111/nyas.12398
   Capellino S, 2010, ANN RHEUM DIS, V69, P1853, DOI 10.1136/ard.2009.119701
   Capistrant BD, 2014, AM J GERIAT PSYCHIAT, V22, P766, DOI 10.1016/j.jagp.2013.01.073
   Castagnetta LA, 2003, J RHEUMATOL, V30, P2597
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   CHROUSOS GP, 2006, ANN NEW YORK ACAD SC
   CIARALDI TP, 1982, DIABETES, V31, P1016, DOI 10.2337/diacare.31.11.1016
   COLLINS JOHN, 1957, MED JOUR AUSTRALIA II, V44, P467
   Dallman MF, 2010, TRENDS ENDOCRIN MET, V21, P159, DOI 10.1016/j.tem.2009.10.004
   DEFRONZO RA, 1979, AM J PHYSIOL, V237, pE214
   DEFRONZO RA, 1988, DIABETES, V37, P667, DOI 10.2337/diab.37.6.667
   DeFronzo RA, 2009, DIABETES, V58, P773, DOI 10.2337/db09-9028
   Dessein PH, 2006, ARTHRITIS RHEUM-US, V54, P2765, DOI 10.1002/art.22053
   Dubreuil M, 2014, RHEUMATOLOGY, V53, P346, DOI 10.1093/rheumatology/ket343
   Edwards C, 2012, J CLIN ENDOCR METAB, V97, P1443, DOI 10.1210/jc.2011-2879
   Edwards EM, 2012, J OCCUP ENVIRON MED, V54, P1447, DOI 10.1097/JOM.0b013e3182783f27
   Ehrhart-Bornstein M, 1998, ENDOCR REV, V19, P101, DOI 10.1210/er.19.2.101
   Esquirol Y, 2009, CHRONOBIOL INT, V26, P544, DOI 10.1080/07420520902821176
   Fall T, 2014, MOL CELL ENDOCRINOL, V382, P740, DOI 10.1016/j.mce.2012.08.018
   FEINGOLD KR, 1992, DIABETES, V41, P97, DOI 10.2337/diab.41.2.S97
   Fernández-Real JM, 1999, DIABETOLOGIA, V42, P1367, DOI 10.1007/s001250051451
   Ferrer B, 2014, BRAIN BEHAV IMMUN, V40, P121, DOI 10.1016/j.bbi.2014.03.001
   Fleischman A, 2008, DIABETES CARE, V31, P289, DOI 10.2337/dc07-1338
   Fredman L, 2010, J GERONTOL A-BIOL, V65, P565, DOI 10.1093/gerona/glq025
   GARVEY WT, 1986, DIABETES, V35, P258, DOI 10.2337/diabetes.35.3.258
   *GEIG PHARM, 1973, WISS TAB
   Glass CK, 2012, CELL METAB, V15, P635, DOI 10.1016/j.cmet.2012.04.001
   Gluckman PD, 2004, TRENDS ENDOCRIN MET, V15, P183, DOI 10.1016/j.tem.2004.03.002
   Goldfine AB, 2011, CLIN CHEM, V57, P162, DOI 10.1373/clinchem.2010.148833
   Goldfine AB, 2010, ANN INTERN MED, V152, P346, DOI 10.7326/0003-4819-152-6-201003160-00004
   Gonzalez-Gay MA, 2006, CLIN EXP RHEUMATOL, V24, P83
   Graham G, 1940, Br Med J, V2, P479
   Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
   Greisen J, 2001, ANESTHESIOLOGY, V95, P578, DOI 10.1097/00000542-200109000-00007
   GRUNBERGER G, 1984, SCIENCE, V223, P932, DOI 10.1126/science.6141638
   HALES CN, 1992, DIABETOLOGIA, V35, P595, DOI 10.1093/ije/dyt133
   Hales CN, 2001, BRIT MED BULL, V60, P5, DOI 10.1093/bmb/60.1.5
   Himsworth HP, 1936, LANCET, V1, P127
   Hitze Britta, 2010, Front Neuroenergetics, V2, P7, DOI 10.3389/fnene.2010.00007
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Hotamisligil GS, 2008, NAT REV IMMUNOL, V8, P923, DOI 10.1038/nri2449
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Iemitsu M, 2000, MED SCI SPORT EXER, V32, P2067, DOI 10.1097/00005768-200012000-00016
   Ikmal SIQS, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/698567
   Jauch-Chara K, 2014, PROG NEUROBIOL, V114, P84, DOI 10.1016/j.pneurobio.2013.12.001
   Jin CC, 2013, CELL METAB, V17, P873, DOI 10.1016/j.cmet.2013.05.011
   Johnson AMF, 2013, CELL, V152, P673, DOI 10.1016/j.cell.2013.01.041
   Joslin EP, 1916, CAN MED ASSOC J, V6, P673
   Kaaja R, 2007, INT J CLIN PHARM TH, V45, P394
   KASUGA M, 1982, NATURE, V298, P667, DOI 10.1038/298667a0
   Keen-Rhinehart E, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00213
   KeltikangasJarvinen L, 1996, METABOLISM, V45, P614, DOI 10.1016/S0026-0495(96)90033-5
   Kiecolt-Glaser JK, 2003, P NATL ACAD SCI USA, V100, P9090, DOI 10.1073/pnas.1531903100
   Kiortsis DN, 2006, J RHEUMATOL, V33, P921
   Kiortsis DN, 2005, ANN RHEUM DIS, V64, P765, DOI 10.1136/ard.2004.026534
   Kitano H, 2004, DIABETES, V53, pS6, DOI 10.2337/diabetes.53.suppl_3.S6
   Kivimäki M, 2006, SCAND J WORK ENV HEA, V32, P431, DOI 10.5271/sjweh.1049
   Korkeila M, 1998, INT J OBESITY, V22, P949, DOI 10.1038/sj.ijo.0800694
   KRIEGER DR, 1988, AM J HYPERTENS, V1, P84, DOI 10.1093/ajh/1.1.84
   Kuipers RS, 2010, BRIT J NUTR, V104, P1666, DOI 10.1017/S0007114510002679
   Kuzawa CW, 1998, YEARB PHYS ANTHROPOL, V41, P177
   Landsberg L, 1999, ANN NY ACAD SCI, V892, P84, DOI 10.1111/j.1749-6632.1999.tb07787.x
   Landsberg L, 2013, J CLIN HYPERTENS, V15, P14, DOI 10.1111/jch.12049
   Larsen CM, 2007, NEW ENGL J MED, V356, P1517, DOI 10.1056/NEJMoa065213
   Levitan RD, 2013, CURR PSYCHIAT REP, V15, DOI 10.1007/s11920-013-0408-x
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   LIEFMANN R, 1950, ACTA MED SCAND, V136, P226
   Lutgendorf SK, 1999, J GERONTOL A-BIOL, V54, pM434, DOI 10.1093/gerona/54.9.M434
   Mahajan A, 2014, NAT GENET, V46, P234, DOI 10.1038/ng.2897
   Mahfoud F, 2011, CIRCULATION, V123, P1940, DOI 10.1161/CIRCULATIONAHA.110.991869
   McAlonan GM, 2007, CAN J PSYCHIAT, V52, P241, DOI 10.1177/070674370705200406
   Meyer-Hermann ME, 2005, J IMMUNOL, V174, P2489, DOI 10.4049/jimmunol.174.5.2489
   MOBERG E, 1994, DIABETOLOGIA, V37, P247
   MOLLER DE, 1991, NEW ENGL J MED, V325, P938
   Montague CT, 1997, NATURE, V387, P903, DOI 10.1038/43185
   Müller N, 2013, PSYCHIAT DANUB, V25, P292
   Müller N, 2002, AM J PSYCHIAT, V159, P1029, DOI 10.1176/appi.ajp.159.6.1029
   Mullington JM, 2009, PROG CARDIOVASC DIS, V51, P294, DOI 10.1016/j.pcad.2008.10.003
   Myers MG, 2012, NATURE, V491, P357, DOI 10.1038/nature11705
   Nairne JS, 2010, COGNITIVE PSYCHOL, V61, P1, DOI 10.1016/j.cogpsych.2010.01.005
   Nakae J, 2008, FEBS LETT, V582, P54, DOI 10.1016/j.febslet.2007.11.025
   Neel JV, 1999, NUTR REV, V57, pS2, DOI 10.1111/j.1753-4887.1999.tb01782.x
   NEEL JV, 1962, AM J HUM GENET, V14, P353
   Osborn O, 2012, NAT MED, V18, P363, DOI 10.1038/nm.2627
   PABST R, 1974, RES EXP MED, V164, P247, DOI 10.1007/BF01851943
   Pemberton R, 1920, ARCH INTERN MED, V25, P243, DOI 10.1001/archinte.1920.00090320014003
   Peters A, 2004, NEUROSCI BIOBEHAV R, V28, P143, DOI 10.1016/j.neubiorev.2004.03.002
   Peters Achim, 2009, Front Neuroenergetics, V1, P2, DOI 10.3389/neuro.14.002.2009
   Pongratz G, 2013, NAT REV RHEUMATOL, V9, P117, DOI 10.1038/nrrheum.2012.181
   Quine S, 1993, Health Soc Work, V18, P114
   Rabinowitch IM, 1924, CAN MED ASSOC J, V14, P481
   RANDLE PJ, 1963, LANCET, V1, P785
   Rassow J, 2008, BIOCHEMISTRY
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Reaven GM, 1998, DIABETOLOGIA, V41, P482, DOI 10.1007/s001250050933
   Reeves KW, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-685
   Rolfe DFS, 1997, PHYSIOL REV, V77, P731, DOI 10.1152/physrev.1997.77.3.731
   Root HF, 1929, NEW ENGL J MED, V201, P0201, DOI 10.1056/NEJM192908012010501
   Roseboom TJ, 2012, PLACENTA, V33, pE40, DOI 10.1016/j.placenta.2012.07.018
   Rosenblat JD, 2014, PROG NEURO-PSYCHOPH, V53, P23, DOI 10.1016/j.pnpbp.2014.01.013
   Schenk S, 2008, J CLIN INVEST, V118, P2992, DOI 10.1172/JCI34260
   Schultz O, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0014328
   Schwartz MW, 2004, J CLIN ENDOCR METAB, V89, P5889, DOI 10.1210/jc.2004-0906
   Sebert S, 2011, AM J CLIN NUTR, V94, p1953S, DOI 10.3945/ajcn.110.001040
   Seematter G, 2000, AM J PHYSIOL-ENDOC M, V279, pE799, DOI 10.1152/ajpendo.2000.279.4.E799
   Serlachius A, 2007, PHYSIOL BEHAV, V92, P548, DOI 10.1016/j.physbeh.2007.04.032
   SHEN SW, 1970, J CLIN INVEST, V49, P2151, DOI 10.1172/JCI106433
   Shoelson SE, 2007, GASTROENTEROLOGY, V132, P2169, DOI 10.1053/j.gastro.2007.03.059
   Sjögren E, 2006, BRAIN BEHAV IMMUN, V20, P270, DOI 10.1016/j.bbi.2005.08.001
   Spalding KL, 2008, NATURE, V453, P783, DOI 10.1038/nature06902
   Stagakis I, 2012, ARTHRITIS RES THER, V14, DOI 10.1186/ar3874
   Straub RH, 2010, J INTERN MED, V267, P543, DOI 10.1111/j.1365-2796.2010.02218.x
   Straub RH, 2012, J MOL MED, V90, P523, DOI 10.1007/s00109-012-0861-8
   Straub RH, 2002, ARTHRITIS RHEUM, V46, P654, DOI 10.1002/art.10177
   Straub RH, 1998, J CLIN ENDOCR METAB, V83, P2012, DOI 10.1210/jc.83.6.2012
   SVENSON KLG, 1987, METABOLISM, V36, P940, DOI 10.1016/0026-0495(87)90128-4
   Taubes G, 2012, NATURE, V492, P155, DOI 10.1038/492155a
   Thomsen V, 1936, ACTA MED SCAND, P918
   Tsigos C, 1997, NEUROENDOCRINOLOGY, V66, P54, DOI 10.1159/000127219
   Tso T, 2004, CLIN RHEUMATOL, V23, P416, DOI 10.1007/s10067-004-0908-5
   UCHIDA I, 1988, BRIT J SURG, V75, P557, DOI 10.1002/bjs.1800750618
   Vaisse C, 1998, NAT GENET, V20, P113, DOI 10.1038/2407
   VANPRAAG HM, 1965, PSYCHOPHARMACOLOGIA, V8, P67, DOI 10.1007/BF00405362
   von Känel R, 2011, J AM GERIATR SOC, V59, P2037, DOI 10.1111/j.1532-5415.2011.03634.x
   Wolfe RR, 1997, BAILLIERE CLIN ENDOC, V11, P645, DOI 10.1016/S0950-351X(97)80926-3
   YALOW RS, 1960, J CLIN INVEST, V39, P1157, DOI 10.1172/JCI104130
   Zunhammer M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0084911
NR 144
TC 56
Z9 57
U1 1
U2 21
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1478-6354
EI 1478-6362
J9 ARTHRITIS RES THER
JI Arthritis Res. Ther.
PY 2014
VL 16
SU 2
AR S4
DI 10.1186/ar4688
PG 15
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA AX9JC
UT WOS:000347218300005
PM 25608958
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, KM
   Han, SM
   Min, IK
   Heo, K
   Kim, WJ
   Chu, MK
AF Kim, Kyung Min
   Han, Seung Min
   Min, In Kyung
   Heo, Kyoung
   Kim, Won-Joo
   Chu, Min Kyung
TI Weekend catch-up sleep and depression: results from a nationally
   representative sample in Korea
SO SLEEP MEDICINE
LA English
DT Article
DE Depressive disorder; Sleep; Epidemiology; Chronobiology phenomena
ID SOCIAL JETLAG; METABOLIC SYNDROME; ASSOCIATION; HEALTH; POPULATION;
   EPIDEMIOLOGY; CHRONOTYPE; PREVALENCE; NUTRITION; DURATION
AB Background: There is limited information on the association between weekend catch-up sleep (CUS), which has beneficial effects on health, and depression. This study aimed to investigate the association between CUS and depression in adults. Methods: We used the data of the Seventh Korea National Health and Nutrition Examination Survey, 2016. Depression was defined as Patient Health Questionnaire-9 score >10. We categorized CUS duration as <0, 0 < to 1, 1 < to 2, and >2 h. Results: Of 5550 eligible participants, 3286 (54.9%), 1033 (19.5%), 723 (14.7%) and 508 (10.9%) had CUS duration <0, 0 < to 1,1 < to 2, and >2 h, respectively; of these, the prevalence of depression was 7.0%, 4.2%, 2.9%, and 6.0%, respectively. Multivariable regression analyses including covariates revealed that individuals with CUS duration 1 < to 2 h had a significantly decreased risk of depression compared to individuals with CUS duration <0 h (odds ratio [OR] = 0.517, 95% CI = 0.309-0.865). Individuals with CUS duration 0 < to 1 h (OR = 0.731, 95% CI = 0.505-1.060) and >2 h (OR = 1.164, 95% CI = 0.718-1.886) showed no significantly different risk of depression. Conclusions: The risk of depression in individuals with CUS duration 1 < to 2 h was lower than for those with CUS duration <0 h. This finding provides a better understanding on the association between CUS and depression; and can be a basis for better management of depression. (c) 2021 Elsevier B.V. All rights reserved.
C1 [Kim, Kyung Min] Yonsei Univ, Yongin Severance Hosp, Dept Neurol, Coll Med, Yongin, South Korea.
   [Han, Seung Min; Heo, Kyoung; Chu, Min Kyung] Yonsei Univ, Severance Hosp, Dept Neurol, Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea.
   [Min, In Kyung] Yonsei Univ, Dept Biomed Syst Informat, Biostat Collaborat Unit, Coll Med, Seoul, South Korea.
   [Kim, Won-Joo] Yonsei Univ, Gangnam Severance Hosp, Dept Neurol, Coll Med, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University Health System; Yonsei University; Yonsei University
   Health System; Yonsei University; Yonsei University Health System
RP Chu, MK (corresponding author), Yonsei Univ, Severance Hosp, Dept Neurol, Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea.
EM chumk@yonsei.ac.kr
RI Kim, Kyung/N-6095-2017; Kim, Kyung/F-3470-2010; Hahn, Seung
   min/MBH-8374-2025
OI Chu, Min Kyung/0000-0001-6221-1346; Kim, Won-Joo/0000-0002-5850-010X;
   Kim, Kyung Min/0000-0002-0261-1687
FU National Research Foundation of Korea (NRF) - Korean government (MSIT)
   [2019R1F1A1052841]
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korean government (MSIT) (2019R1F1A1052841).
CR Adan A, 2012, CHRONOBIOL INT, V29, P1153, DOI 10.3109/07420528.2012.719971
   Andrade L, 2003, INT J METH PSYCH RES, V12, P3, DOI 10.1002/mpr.138
   [Anonymous], 2013, subjects, DOI 10.1001/jama.2013.281053
   Association AP, 2013, Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
   Au J, 2017, J AFFECT DISORDERS, V218, P93, DOI 10.1016/j.jad.2017.04.021
   Basnet S, 2017, CHRONOBIOL INT, V34, P462, DOI 10.1080/07420528.2017.1295050
   Bjelland I, 2008, SOC SCI MED, V66, P1334, DOI 10.1016/j.socscimed.2007.12.019
   CAMACHO TC, 1991, AM J EPIDEMIOL, V134, P220, DOI 10.1093/oxfordjournals.aje.a116074
   CARSKADON MA, 1993, SLEEP, V16, P258, DOI 10.1093/sleep/16.3.258
   Choi HS, 2007, KOREAN J FAM MED, V28, P114
   Depner CM, 2019, CURR BIOL, V29, P957, DOI 10.1016/j.cub.2019.01.069
   Fang H, 2019, J CELL MOL MED, V23, P2324, DOI 10.1111/jcmm.14170
   Fava M, 2004, J CLIN PSYCHIAT, V65, P27
   Ferrari AJ, 2013, PLOS MED, V10, DOI 10.1371/journal.pmed.1001547
   Fluharty M, 2017, NICOTINE TOB RES, V19, P3, DOI 10.1093/ntr/ntw140
   Gupta Rakesh M, 2002, Med Health R I, V85, P86
   Henderson SEM, 2019, CHRONOBIOL INT, V36, P1316, DOI 10.1080/07420528.2019.1636813
   Hertenstein E, 2019, SLEEP MED REV, V43, P96, DOI 10.1016/j.smrv.2018.10.006
   Hublin C, 2001, SLEEP, V24, P392, DOI 10.1093/sleep/24.4.392
   Hwangbo Y, 2013, SLEEP MED, V14, P549, DOI 10.1016/j.sleep.2013.02.009
   Im HJ, 2017, SLEEP, V40, DOI 10.1093/sleep/zsx089
   Islam Z, 2018, SLEEP MED, V51, P53, DOI 10.1016/j.sleep.2018.07.003
   Kang SG, 2014, COMPR PSYCHIAT, V55, P319, DOI 10.1016/j.comppsych.2013.08.023
   Kantermann T, 2013, WORK, V46, P273, DOI 10.3233/WOR-121531
   Killick R, 2015, CLIN ENDOCRINOL, V83, P498, DOI 10.1111/cen.12747
   Koo DL, 2021, J SLEEP RES, V30, DOI 10.1111/jsr.13063
   Korea Centers for Disease Control and Prevention, KOR NAT HLTH NUTR EX
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Kweon S, 2014, INT J EPIDEMIOL, V43, P69, DOI 10.1093/ije/dyt228
   Lane JM, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms10889
   Lee J, 2018, J OCCUP ENVIRON MED, V60, P775, DOI 10.1097/JOM.0000000000001359
   Leger D, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0045204
   Lockley SW, 1999, J SLEEP RES, V8, P175, DOI 10.1046/j.1365-2869.1999.00155.x
   Maske UE, 2015, BMC PSYCHIATRY, V15, DOI 10.1186/s12888-015-0463-4
   Merikanto I, 2015, J AFFECT DISORDERS, V188, P143, DOI 10.1016/j.jad.2015.08.061
   Organization WH, Global physical activity questionnaire (GPAQ) analysis guide
   Parsons MJ, 2015, INT J OBESITY, V39, P842, DOI 10.1038/ijo.2014.201
   Roenneberg T, 2007, SLEEP MED REV, V11, P429, DOI 10.1016/j.smrv.2007.07.005
   Schaetz L, 2020, IMPACT EMPLOYER PROV
   SCHRADER H, 1993, J SLEEP RES, V2, P51, DOI 10.1111/j.1365-2869.1993.tb00061.x
   Son SM, 2020, DIABET METAB SYND OB, V13, P1465, DOI 10.2147/DMSO.S247898
   Sullivan LE, 2005, AM J MED, V118, P330, DOI 10.1016/j.amjmed.2005.01.007
   van den Berg JF, 2018, CHRONOBIOL INT, V35, P1248, DOI 10.1080/07420528.2018.1470531
   Vos T, 2016, LANCET, V388, P1545, DOI 10.1016/s0140-6736(16)31678-6
   WILSON SH, 1993, PUBLIC HEALTH, V107, P153, DOI 10.1016/S0033-3506(05)80436-6
   WING JK, 1990, ARCH GEN PSYCHIAT, V47, P589
   Wittmann M, 2006, CHRONOBIOL INT, V23, P497, DOI 10.1080/07420520500545979
   Zhai L, 2015, DEPRESS ANXIETY, V32, P664, DOI 10.1002/da.22386
NR 48
TC 21
Z9 21
U1 4
U2 26
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1389-9457
EI 1878-5506
J9 SLEEP MED
JI Sleep Med.
PD NOV
PY 2021
VL 87
BP 62
EP 68
DI 10.1016/j.sleep.2021.02.058
EA SEP 2021
PG 7
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA UX7NZ
UT WOS:000701028700009
PM 34520972
DA 2025-06-11
ER

PT J
AU Bengesser, SA
   Lackner, N
   Birner, A
   Platzer, M
   Fellendorf, FT
   Queissner, R
   Filic, K
   Reininghaus, B
   Wallner-Liebmann, SJ
   Mangge, H
   Zelzer, S
   Fuchs, D
   Kapfhammer, HP
   McIntyre, RS
   Reininghaus, EZ
AF Bengesser, Susanne A.
   Lackner, Nina
   Birner, Armin
   Platzer, Martina
   Fellendorf, Frederike T.
   Queissner, Robert
   Filic, Kristijan
   Reininghaus, Bernd
   Wallner-Liebmann, Sandra J.
   Mangge, Harald
   Zelzer, Sieglinde
   Fuchs, Dietmar
   Kapfhammer, Hans-Peter
   McIntyre, Roger S.
   Reininghaus, Eva Z.
TI Mood Stabilizers, Oxidative Stress and Antioxidative Defense in Euthymia
   of Bipolar Disorder
SO CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
LA English
DT Article
DE Oxidative stress; antioxidative parameters; malondialdehyde; carbonyl
   proteins; glutathione S-transferase
ID GLUTATHIONE-S-TRANSFERASE; ANIMAL-MODEL; LIPID-PEROXIDATION;
   NITRIC-OXIDE; SUPEROXIDE-DISMUTASE; METABOLIC SYNDROME; AUTOIMMUNE
   RESPONSES; MAJOR DEPRESSION; DNA-DAMAGE; LITHIUM
AB Background: Hitherto literature indicates that mood stabilizers exert variable effects on oxidative and antioxidative systems, which are involved in the pathogenesis of Bipolar Disorder. Herein we primarily sought to characterize markers of peripheral oxidative stress during euthymia in adults with Bipolar Disorder under current intake of different mood stabilizers (lithium, anticonvulsants and atypical antipsychotics/AAPs).
   Methods: Peripheral oxidative stress parameters (TBARS/Thiobarbituric acid-reactive-substances, MDA/malondial-dehyde and carbonyl proteins) and antioxidative markers (SOD/Cu/Zn superoxide dismutase, GST/glutathione S-transferase and TAC/total antioxidative capacity) were measured in serum of 115 euthymic bipolar individuals (50 females, 65 males; HAMD<11 and YMRS<8). Differences in (anti) oxidative markers between bipolar participants treated with different mood stabilizing medication were tested with MANCOVAS and ANCOVAS with SPSS.21.
   Results: Bipolar individuals taking lithium had significantly lower oxidative parameters than test persons without lithium (multivariate effect for MDA and TBARS: F(2/182)= 3.956, p= 0.021; univariate effect for MDA: F(2/182)= 7.880, p= 0.006, Partial eta 2=0.041). Subjects with AAPs had significantly higher MDA and TBARS levels compared to participants without AAPs (multivariate effect F(2/182)= 3.122, p= 0.046, Partial eta 2=0.033). Patients taking anticonvulsants had significantly lower GST levels than patients without antiepileptic medication (F(1/165)= 4.501, p= 0.035, Partial eta 2= 0.027).
   Conclusion: Lithium taking participants had the lowest MDA and TBARS levels, while AAP taking test persons had high oxidative stress markers. The observed effects on oxidative markers may provide a mechanistic basis for understanding lithium's neuroprotective effects.
C1 [Bengesser, Susanne A.; Lackner, Nina; Birner, Armin; Platzer, Martina; Fellendorf, Frederike T.; Queissner, Robert; Filic, Kristijan; Kapfhammer, Hans-Peter; Reininghaus, Eva Z.] Med Univ Graz, Dept Psychiat, Auenbruggerpl 31, A-8036 Graz, Austria.
   [Wallner-Liebmann, Sandra J.] Med Univ Graz, Dept Pathophysiol & Immunol, A-8036 Graz, Austria.
   [Mangge, Harald; Zelzer, Sieglinde] Med Univ Graz, Clin Dept Med & Chem Lab Diagnost, A-8036 Graz, Austria.
   [Fuchs, Dietmar] Med Univ Graz, Dept Chem Lab Diagnost, A-8036 Graz, Austria.
   [Reininghaus, Bernd] Therapiezentrum Justuspk, Bad Hall, Austria.
   [McIntyre, Roger S.] Univ Toronto, Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.
C3 Medical University of Graz; Medical University of Graz; Medical
   University of Graz; Medical University of Graz; University of Toronto;
   University Health Network Toronto
RP Lackner, N (corresponding author), Med Univ Graz, Dept Psychiat, Auenbruggerpl 31, A-8036 Graz, Austria.
EM Nina.Lackner@medunigraz.at
RI Fuchs, Dietmar/AAL-8011-2021; McIntyre, Roger/AAU-1000-2020
OI Reininghaus, Eva/0000-0001-5964-4087; Mangge,
   Harald/0000-0003-4067-247X; Fellendorf, Frederike/0000-0001-7215-3848
FU "Stadt Graz" (Project: "Fettstoffwechselstorungen und anthropometrische
   Besonderheiten bei PatientInnen mit bipolarer affektiver Storung");
   "Osterreichische kardiologische Gesellschaft" (Project: "BIPFAT -
   neurobiological background of cardiovascular comorbidities and obesity
   in bipolar disorder")
FX The pilot study was funded by the "Stadt Graz" (Project:
   "Fettstoffwechselstorungen und anthropometrische Besonderheiten bei
   PatientInnen mit bipolarer affektiver Storung") and the "Osterreichische
   kardiologische Gesellschaft" (Project: "BIPFAT - neurobiological
   background of cardiovascular comorbidities and obesity in bipolar
   disorder").
CR Albayrak A, 2013, INT IMMUNOPHARMACOL, V16, P35, DOI 10.1016/j.intimp.2013.03.018
   Andreazza AC, 2008, J AFFECT DISORDERS, V111, P135, DOI 10.1016/j.jad.2008.04.013
   Andreazza AC, 2008, J PSYCHIATR NEUROSCI, V33, P516
   Andreazza AC, 2009, J PSYCHIATR NEUROSCI, V34
   [Anonymous], KOMPENDIUM PRAKTISCH
   Bakare A, 2009, NEUROSCI LETT, V455, P70, DOI 10.1016/j.neulet.2009.03.022
   Banerjee U, 2012, PROG NEURO-PSYCHOPH, V37, P56, DOI 10.1016/j.pnpbp.2011.12.006
   BENGESSER S., 2013, GENETICS BIPOLAR DIS
   Bengesser SA, 2015, J AFFECT DISORDERS, V172, P367, DOI 10.1016/j.jad.2014.10.014
   Berk M, 2011, NEUROSCI BIOBEHAV R, V35, P804, DOI 10.1016/j.neubiorev.2010.10.001
   Bortolasci CC, 2014, J AFFECT DISORDERS, V159, P23, DOI 10.1016/j.jad.2014.02.018
   Contreras-Shannon V, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059012
   Cosi C, 2005, BRAIN RES, V1043, P32, DOI 10.1016/j.brainres.2005.02.072
   Cui J, 2007, NEUROSCIENCE, V144, P1447, DOI 10.1016/j.neuroscience.2006.11.010
   da-Rosa DD, 2012, PSYCHIAT RES, V198, P521, DOI 10.1016/j.psychres.2012.01.019
   Dalvi SM, 2013, MALAYS J MED SCI, V20, P21
   Diniz BS, 2013, NEUROPSYCH DIS TREAT, V9, P493, DOI 10.2147/NDT.S33086
   Fagiolini A, 2008, J CLIN PSYCHIAT, V69, P678, DOI 10.4088/JCP.v69n0423c
   Feng HL, 2008, NEUROSCIENCE, V155, P567, DOI 10.1016/j.neuroscience.2008.06.040
   Forlenza OV, 2012, DRUG AGING, V29, P335, DOI 10.2165/11599180-000000000-00000
   Frey BN, 2007, PROG NEURO-PSYCHOPH, V31, P283, DOI 10.1016/j.pnpbp.2006.06.011
   Frey BN, 2006, J PSYCHIATR NEUROSCI, V31, P326
   Garcia-Portilla MP, 2009, J AFFECT DISORDERS, V115, P302, DOI 10.1016/j.jad.2008.09.008
   Gawryluk JW, 2011, INT J NEUROPSYCHOPH, V14, P1069, DOI 10.1017/S1461145711000617
   Gergerlioglu HS, 2007, PROG NEURO-PSYCHOPH, V31, P697, DOI 10.1016/j.pnpbp.2006.12.020
   Ghedim FV, 2012, J PSYCHIATR RES, V46, P1569, DOI 10.1016/j.jpsychires.2012.08.010
   He J, 2004, BRAIN RES, V1018, P186, DOI 10.1016/j.brainres.2004.05.060
   Himmerich H, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/806162
   Hoogendoorn B, 2004, HUM MUTAT, V24, P35, DOI 10.1002/humu.20061
   Jornada LK, 2011, J PSYCHIATR RES, V45, P162, DOI 10.1016/j.jpsychires.2010.05.011
   Kapczinski F, 2011, J PSYCHIATR RES, V45, P156, DOI 10.1016/j.jpsychires.2010.05.015
   Khairova R, 2012, MOL MED REP, V5, P680, DOI 10.3892/mmr.2011.732
   Kuloglu M, 2002, CELL BIOCHEM FUNCT, V20, P171, DOI 10.1002/cbf.940
   Lai JS, 2006, EUR J PHARMACOL, V539, P18, DOI 10.1016/j.ejphar.2006.03.076
   Lenaz G, 2000, BBA-BIOENERGETICS, V1459, P397, DOI 10.1016/S0005-2728(00)00177-8
   Macêdo DS, 2012, BIPOLAR DISORD, V14, P707, DOI 10.1111/j.1399-5618.2012.01046.x
   Ximenes JCM, 2013, N-S ARCH PHARMACOL, V386, P575, DOI 10.1007/s00210-013-0853-4
   Machado-Vieira R, 2007, NEUROSCI LETT, V421, P33, DOI 10.1016/j.neulet.2007.05.016
   Maes M, 2013, ACTA PSYCHIAT SCAND, V127, P344, DOI 10.1111/j.1600-0447.2012.01908.x
   Maes M, 2013, J AFFECT DISORDERS, V149, P23, DOI 10.1016/j.jad.2012.06.039
   Maes M, 2011, PROG NEURO-PSYCHOPH, V35, P676, DOI 10.1016/j.pnpbp.2010.05.004
   Magliaro BC, 2009, BRAIN RES, V1283, P14, DOI 10.1016/j.brainres.2009.05.063
   Mangge H, 2004, CLIN CHEM LAB MED, V42, P467, DOI 10.1515/CCLM.2004.081
   Mangge H, 2010, CURR MED CHEM, V17, P4511, DOI 10.2174/092986710794183006
   Martins MR, 2008, NEUROTOX RES, V13, P63, DOI 10.1007/BF03033368
   McIntyre RS, 2010, ADV THER, V27, P828, DOI 10.1007/s12325-010-0072-z
   McIntyre RS, 2010, J AFFECT DISORDERS, V126, P366, DOI 10.1016/j.jad.2010.04.012
   Moylan S, 2013, MOL PSYCHIATR, V18, P595, DOI 10.1038/mp.2012.33
   Nciri R, 2013, INT J NEUROPSYCHOPH, V16, P365, DOI 10.1017/S1461145712000132
   Ozcan ME, 2004, INT CLIN PSYCHOPHARM, V19, P89, DOI 10.1097/01.yic.0000110796.97676.89
   Peng L, 2013, SCHIZOPHR RES, V147, P14, DOI 10.1016/j.schres.2013.03.006
   Pillai A, 2007, J PSYCHIATR RES, V41, P372, DOI 10.1016/j.jpsychires.2006.01.011
   Quiroz JA, 2010, NEUROPSYCHOBIOLOGY, V62, P50, DOI 10.1159/000314310
   Ranjekar PK, 2003, PSYCHIAT RES, V121, P109, DOI 10.1016/S0165-1781(03)00220-8
   Reininghaus EZ, 2014, NERVENARZT, V85, P1099, DOI 10.1007/s00115-013-3962-x
   Reininghaus EZ, 2014, BIPOLAR DISORD, V16, P432, DOI 10.1111/bdi.12166
   Reinke A, 2004, NEUROSCI LETT, V372, P157, DOI 10.1016/j.neulet.2004.09.032
   Rezaei Z, 2012, PSYCHIAT RES, V198, P166, DOI 10.1016/j.psychres.2011.09.002
   Riadh N, 2011, BIOMETALS, V24, P747, DOI 10.1007/s10534-011-9433-6
   Rodríguez-Santiago B, 2010, MOL PSYCHIATR, V15, P1023, DOI 10.1038/mp.2009.53
   Savas HA, 2006, WORLD J BIOL PSYCHIA, V7, P51, DOI 10.1080/15622970510029993
   Selek S, 2008, J AFFECT DISORDERS, V107, P89, DOI 10.1016/j.jad.2007.08.006
   Shao L, 2008, NEUROSCIENCE, V151, P518, DOI 10.1016/j.neuroscience.2007.10.041
   Soczynska JK, 2011, NEUROMOL MED, V13, P93, DOI 10.1007/s12017-010-8140-8
   Stefanescu C, 2012, J AFFECT DISORDERS, V143, P34, DOI 10.1016/j.jad.2012.05.022
   Tsai SY, 2012, J AFFECT DISORDERS, V136, P110, DOI 10.1016/j.jad.2011.08.022
   Türkez H, 2010, TOXICOL IND HEALTH, V26, P583, DOI 10.1177/0748233710373090
   Vancampfort D, 2013, AM J PSYCHIAT, V170, P265, DOI 10.1176/appi.ajp.2012.12050620
   Vargas HO, 2013, J AFFECT DISORDERS, V150, P923, DOI 10.1016/j.jad.2013.05.016
   Wang JF, 2004, J NEUROCHEM, V88, P1477, DOI 10.1046/j.1471-4159.2003.02276.x
   Wang JF, 2003, NEUROSCIENCE, V116, P485, DOI 10.1016/S0306-4522(02)00655-3
   Yang MC, 2011, PSYCHOPHARMACOLOGY, V217, P397, DOI 10.1007/s00213-011-2291-7
   Yazicioglu RA, 2007, TOHOKU J EXP MED, V213, P79, DOI 10.1620/tjem.213.79
   Yulug B, 2006, BRAIN RES BULL, V69, P656, DOI 10.1016/j.brainresbull.2006.03.017
NR 74
TC 22
Z9 27
U1 0
U2 12
PU BENTHAM SCIENCE PUBL
PI BUSUM
PA PO BOX 294, BUSUM, 1400 AG, NETHERLANDS
SN 1871-5273
EI 1996-3181
J9 CNS NEUROL DISORD-DR
JI CNS Neurol. Disord.-Drug Targets
PY 2016
VL 15
IS 4
BP 381
EP 389
DI 10.2174/1871527315666160321104059
PG 9
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA DI9DU
UT WOS:000373802500004
PM 26996179
DA 2025-06-11
ER

PT J
AU Mariana, M
   Castelo-Branco, M
   Soares, AM
   Cairrao, E
AF Mariana, Melissa
   Castelo-Branco, Miguel
   Soares, Amadeu M.
   Cairrao, Elisa
TI Phthalates' exposure leads to an increasing concern on cardiovascular
   health
SO JOURNAL OF HAZARDOUS MATERIALS
LA English
DT Review
DE Endocrine disrupting compounds; Plasticizers; Human health;
   Cardiovascular diseases; Cardiometabolic risk factors
ID CORONARY-HEART-DISEASE; BODY-MASS INDEX; ENDOCRINE-DISRUPTING CHEMICALS;
   BISPHENOL-A; METABOLITE CONCENTRATIONS; URINARY CONCENTRATIONS;
   BLOOD-PRESSURE; CARDIOMETABOLIC RISK; INSULIN-RESISTANCE; OXIDATIVE
   STRESS
AB Being an essential component in the plastics industry, phthalates are ubiquitous in the environment and in everyday life. They are considered environmental contaminants that have been classified as endocrine-disrupting compounds. Despite di-2-ethylhexyl phthalate (DEHP) being the most common plasticizer and the most studied to date, there are many others that, in addition to being widely used in the plastic, are also applied in the medical and pharmaceutical industries and cosmetics. Due to their wide use, phthalates are easily absorbed by the human body where they can disrupt the endocrine system by binding to molecular targets and interfering with hormonal homeostasis. Thus, phthalates exposure has been implicated in the development of several diseases in different age groups. Collecting information from the most recent available literature, this review aims to relate human phthalates' exposure with the development of cardiovascular diseases throughout all ages. Overall, most of the studies presented demonstrated an association between phthalates and several cardiovascular diseases, either from prenatal or postnatal exposure, affecting foetuses, infants, children, young and older adults. However, the mechanisms underlying these effects remain poorly explored. Thus, considering the cardiovascular diseases incidence worldwide and the constant human exposure to phthalates, this topic should be extensively studied to understand the mechanisms involved.
C1 [Mariana, Melissa; Castelo-Branco, Miguel; Cairrao, Elisa] Univ Beira Interior, CICS UBI Hlth Sci Res Ctr, P-6200506 Covilha, Portugal.
   [Castelo-Branco, Miguel; Cairrao, Elisa] Univ Beira Interior, FCS UBI Fac Hlth Sci, P-6200506 Covilha, Portugal.
   [Soares, Amadeu M.] Univ Aveiro, CESAM Ctr Environm & Marine Studies, Dept Biol, P-3810193 Aveiro, Portugal.
   [Cairrao, Elisa] Univ Beira Interior, Ctr Invest Ciencias Saude, Ave Infante D Henr s-n, P-6200506 Covilha, Portugal.
C3 Universidade da Beira Interior; Universidade da Beira Interior;
   Universidade de Aveiro; Universidade da Beira Interior
RP Cairrao, E (corresponding author), Univ Beira Interior, Ctr Invest Ciencias Saude, Ave Infante D Henr s-n, P-6200506 Covilha, Portugal.
EM ecairrao@fcsaude.ubi.pt
RI Sousa, Miguel/F-7869-2010; Soares, Amadeu/A-8304-2008; Cairrao,
   Elisa/AAB-1164-2020
OI Soares, Amadeu/0000-0003-0879-9470; Mariana,
   Melissa/0000-0003-1875-0144; Cairrao, Elisa/0000-0002-4823-5701
FU Portuguese Foundation for Science and Technology/MCTES [UIDB/00709/2020,
   UIDP/00709/2020]; FCT; FCT/MCTES [2020.07020. BD];  [UIDP/50017/2020 +
   UIDB/50017/2020 + LA/P/0094/2020]
FX This work was developed within the scope of the CICS-UBI projects
   UIDB/00709/2020 and UIDP/00709/2020, financed by national funds through
   the Portuguese Foundation for Science and Technology/MCTES. Melissa
   Mariana acknowledges the PhD fellowship from FCT (Reference: 2020.07020.
   BD) . Thanks are due to FCT/MCTES for the financial support to CESAM
   (UIDP/50017/2020 + UIDB/50017/2020 + LA/P/0094/2020) , through national
   funds. The authors would like to acknowledge to the anonymous reviewers
   for their suggestions and significant contribution for the improvement
   of the manuscript. To make the figures we used pictures from Smart
   Servier Medical Art, licensed under a Creative Commons Attribution 3.0
   unported license (https://smart.servier.com /) .
CR Agay-Shay K, 2015, ENVIRON HEALTH PERSP, V123, P1030, DOI 10.1289/ehp.1409049
   Al-Bazi MM, 2022, ENVIRON SCI POLLUT R, V29, P28743, DOI 10.1007/s11356-021-18361-x
   Amin MM, 2018, CHEMOSPHERE, V211, P547, DOI 10.1016/j.chemosphere.2018.07.172
   Amin MM, 2018, ENVIRON SCI POLLUT R, V25, P11143, DOI 10.1007/s11356-018-1413-8
   Ashley-Martin J, 2021, INT J HYG ENVIR HEAL, V232, DOI 10.1016/j.ijheh.2021.113689
   Attina TM, 2015, J CLIN ENDOCR METAB, V100, P2640, DOI 10.1210/jc.2015-1686
   Bai CH, 2022, ENVIRON RES, V207, DOI 10.1016/j.envres.2021.112657
   Bai PY, 2017, ENVIRON RES, V158, P366, DOI 10.1016/j.envres.2017.06.021
   Barrett ES, 2022, ENVIRON INT, V160, DOI 10.1016/j.envint.2022.107078
   BARRY YA, 1989, J THORAC CARDIOV SUR, V97, P900
   Bauer M, 2012, SWISS MED WKLY, V142, DOI 10.4414/smw.2012.13705
   Bedell SM, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph182010627
   Bellavia A, 2017, INT J HYG ENVIR HEAL, V220, P1347, DOI 10.1016/j.ijheh.2017.09.005
   Benjamin S, 2017, J HAZARD MATER, V340, P360, DOI 10.1016/j.jhazmat.2017.06.036
   Berger K, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18041796
   Berman YE, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18094725
   Berman YE, 2021, ENVIRON RES, V195, DOI 10.1016/j.envres.2020.110313
   Botton J, 2016, ENVIRON RES, V151, P601, DOI 10.1016/j.envres.2016.08.033
   Bräuner EV, 2022, ENVIRON INT, V158, DOI 10.1016/j.envint.2021.106987
   Buckley JP, 2016, EPIDEMIOLOGY, V27, P449, DOI 10.1097/EDE.0000000000000436
   Buckley JP, 2016, ENVIRON HEALTH PERSP, V124, P507, DOI 10.1289/ehp.1509788
   Cai FS, 2023, ENVIRON POLLUT, V316, DOI 10.1016/j.envpol.2022.120536
   Campbell JL, 2018, ENVIRON INT, V113, P91, DOI 10.1016/j.envint.2018.01.023
   Campesi I, 2021, LIFE-BASEL, V11, DOI 10.3390/life11010052
   Cantonwine DE, 2016, ENVIRON HEALTH PERSP, V124, P1651, DOI 10.1289/EHP188
   Carlsson A, 2018, ENDOCR CONNECT, V7, P232, DOI 10.1530/EC-17-0344
   Chang CH, 2020, SCI TOTAL ENVIRON, V737, DOI 10.1016/j.scitotenv.2020.139833
   Chang WH, 2021, SCI TOTAL ENVIRON, V786, DOI 10.1016/j.scitotenv.2021.147371
   Chatterjee A, 2012, CAN FAM PHYSICIAN, V58, P389
   Chen CW, 2021, TOXICS, V9, DOI 10.3390/toxics9120351
   Chen CY, 2015, SCI TOTAL ENVIRON, V517, P125, DOI 10.1016/j.scitotenv.2015.02.021
   Chen SY, 2017, ENVIRON POLLUT, V225, P112, DOI 10.1016/j.envpol.2017.03.037
   Dales RE, 2018, SCI TOTAL ENVIRON, V612, P1287, DOI 10.1016/j.scitotenv.2017.09.009
   Das MT, 2021, J HAZARD MATER, V409, DOI 10.1016/j.jhazmat.2020.124496
   Deierlein AL, 2022, ENVIRON RES, V209, DOI 10.1016/j.envres.2022.112835
   Dirinck E, 2015, ENVIRON RES, V137, P419, DOI 10.1016/j.envres.2015.01.010
   Dirtu AC, 2013, ENVIRON INT, V59, P344, DOI 10.1016/j.envint.2013.06.023
   Dong RH, 2018, ENVIRON INT, V121, P340, DOI 10.1016/j.envint.2018.09.028
   Dong RH, 2017, INT J ENV RES PUB HE, V14, DOI 10.3390/ijerph14060598
   Duan YS, 2021, ENVIRON INT, V155, DOI 10.1016/j.envint.2021.106609
   Duan YS, 2019, SCI TOTAL ENVIRON, V670, P41, DOI 10.1016/j.scitotenv.2019.03.192
   Duan YS, 2017, ENVIRON INT, V109, P53, DOI 10.1016/j.envint.2017.09.002
   EPA U.S.E.P.A., 2014, PRIOR POLL LIST US
   Farnbach K, 2019, J PERINATOL, V39, P1528, DOI 10.1038/s41372-019-0457-z
   Filardi T, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020525
   Fisher BG, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00099
   Gaffney B, 2021, INTEGR BLOOD PRESS C, V14, P179, DOI 10.2147/IBPC.S286957
   Gao H, 2021, ENVIRON INT, V155, DOI 10.1016/j.envint.2021.106677
   Gillum N, 2009, TOXICOL APPL PHARM, V236, P25, DOI 10.1016/j.taap.2008.12.027
   Guess M, 2022, MATERIALS, V15, DOI 10.3390/ma15030724
   Guo J, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17113857
   Güven C, 2016, FOOD CHEM TOXICOL, V93, P41, DOI 10.1016/j.fct.2016.04.023
   Han XY, 2020, ECOTOX ENVIRON SAFE, V189, DOI 10.1016/j.ecoenv.2019.109944
   Harley KG, 2017, PEDIATR RES, V82, P405, DOI 10.1038/pr.2017.112
   Harley KG, 2016, ENVIRON HEALTH PERSP, V124, P1600, DOI 10.1289/ehp.1510514
   Heggeseth BC, 2019, ENVIRON RES, V175, P22, DOI 10.1016/j.envres.2019.04.036
   Hill M, 2021, PHYSIOL RES, V70, pS617, DOI 10.33549/physiolres.934794
   Hoffman MR., 2020, StatPearls
   Hoppin JA, 2002, ENVIRON HEALTH PERSP, V110, P515, DOI 10.1289/ehp.02110515
   Jaimes R, 2019, CIRC-ARRHYTHMIA ELEC, V12, DOI 10.1161/CIRCEP.119.007294
   James-Todd T, 2022, ENVIRON INT, V161, DOI 10.1016/j.envint.2022.107099
   James-Todd T, 2012, ENVIRON HEALTH PERSP, V120, P1307, DOI 10.1289/ehp.1104717
   James-Todd TM, 2018, ENVIRON HEALTH-GLOB, V17, DOI 10.1186/s12940-018-0399-5
   James-Todd TM, 2016, ENVIRON INT, V96, P118, DOI 10.1016/j.envint.2016.09.009
   James-Todd TM, 2016, ENVIRON HEALTH-GLOB, V15, DOI 10.1186/s12940-016-0136-x
   Javeed A, 2022, COMPUT MATH METHOD M, V2022, DOI 10.1155/2022/9288452
   Jenkins R., 2021, TOXICS, V9
   Jenkins R, 2019, PEDIATR NEPHROL, V34, P1413, DOI 10.1007/s00467-019-04244-4
   Kang Y., 2019, ANN OCCUP ENVIRON ME, V31, P23
   Kim JH, 2016, J EPIDEMIOL COMMUN H, V70, P466, DOI 10.1136/jech-2015-206315
   Kim SM, 2015, TOXICOL IN VITRO, V30, P383, DOI 10.1016/j.tiv.2015.09.026
   Kim Shin Hye, 2014, Ann Pediatr Endocrinol Metab, V19, P69, DOI 10.6065/apem.2014.19.2.69
   Kim S, 2015, SCI TOTAL ENVIRON, V508, P13, DOI 10.1016/j.scitotenv.2014.11.019
   Kolena B, 2022, TOXICS, V10, DOI 10.3390/toxics10030143
   Kupsco A, 2021, ENVIRON RES, V192, DOI 10.1016/j.envres.2020.110341
   Kvandová M, 2016, PHYSIOL RES, V65, pS343, DOI 10.33549/physiolres.933439
   Lalan S, 2018, J PEDIATR-US, V202, P163, DOI 10.1016/j.jpeds.2018.06.007
   Latini G, 2003, ENVIRON HEALTH PERSP, V111, P1783, DOI 10.1289/ehp.6202
   Lee I, 2021, ENVIRON INT, V146, DOI 10.1016/j.envint.2020.106227
   Li AJ, 2019, ENVIRON INT, V126, P153, DOI 10.1016/j.envint.2019.01.082
   Li YL, 2020, ECOTOX ENVIRON SAFE, V201, DOI 10.1016/j.ecoenv.2020.110749
   Liang QX, 2022, INT J GEN MED, V15, P179, DOI 10.2147/IJGM.S335895
   Lin CY, 2022, SCI TOTAL ENVIRON, V808, DOI 10.1016/j.scitotenv.2021.152054
   Lin CY, 2020, ENVIRON POLLUT, V265, DOI 10.1016/j.envpol.2020.114912
   Lin CY, 2016, ENVIRON INT, V92-93, P157, DOI 10.1016/j.envint.2016.04.006
   Lind PM, 2011, ATHEROSCLEROSIS, V218, P207, DOI 10.1016/j.atherosclerosis.2011.05.001
   Liu J, 2022, THERANOSTICS, V12, P1342, DOI 10.7150/thno.65778
   Lodrini AM, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.750510
   Lorigo M, 2022, MOL ASPECTS MED, V87, DOI 10.1016/j.mam.2021.101054
   Lorigo M, 2020, J CARDIOVASC TRANSL, V13, P55, DOI 10.1007/s12265-019-09939-5
   Louis GMB, 2019, EPIDEMIOLOGY, V30, pS65, DOI 10.1097/EDE.0000000000001082
   Main KM, 2006, ENVIRON HEALTH PERSP, V114, P270, DOI 10.1289/ehp.8075
   Mansouri V, 2019, ENVIRON SCI POLLUT R, V26, P18604, DOI 10.1007/s11356-019-05123-z
   Maresca MM, 2016, ENVIRON HEALTH PERSP, V124, P514, DOI 10.1289/ehp.1408750
   Mariana M, 2022, CELL MOL NEUROBIOL, V42, P2289, DOI 10.1007/s10571-021-01103-5
   Mariana M, 2016, ENVIRON INT, V94, P758, DOI 10.1016/j.envint.2016.07.004
   Martínez-Ibarra A, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20133343
   Marx RG, 2015, J BONE JOINT SURG AM, V97A, P1, DOI 10.2106/JBJS.N.01112
   Mathew L, 2021, SCI TOTAL ENVIRON, V796, DOI 10.1016/j.scitotenv.2021.148898
   Meeker JD, 2009, PHILOS T R SOC B, V364, P2097, DOI 10.1098/rstb.2008.0268
   Melough MMM, 2022, ENVIRON RES, V211, DOI 10.1016/j.envres.2022.113049
   Mengozzi A, 2021, ENVIRON RES, V192, DOI 10.1016/j.envres.2020.110316
   Nam D, 2020, ANN OCCUP ENVIRON ME, V32, DOI 10.35371/aoem.2020.32.e34
   NCBI-National Center for Biotechnology Information, 2022, PubChem Compound Summary for CID 16723172, Sulfoxaflor
   Noor N, 2019, INT J HYG ENVIR HEAL, V222, P395, DOI 10.1016/j.ijheh.2018.12.005
   OCEBM Levels of Evidence Working Group, 2011, OXFORD LEVELS EVIDEN, P2
   Osman AM, 2010, REPROD TOXICOL, V30, P322, DOI 10.1016/j.reprotox.2010.05.084
   Pacovsky J, 2011, Rozhl Chir, V90, P478
   Pepin ME, 2019, AM J PHYSIOL-HEART C, V317, pH674, DOI 10.1152/ajpheart.00016.2019
   Peres GM, 2018, J CARDIOVASC DEV DIS, V5, DOI 10.3390/jcdd5010003
   Philips E.M., 2017, REPROD TOXICOL
   Philips EM, 2020, ENVIRON INT, V135, DOI 10.1016/j.envint.2019.105342
   Philips EM, 2019, HUM REPROD, V34, P365, DOI 10.1093/humrep/dey364
   Piecha R, 2016, CENT EUR J PUBL HEAL, V24, P297, DOI 10.21101/cejph.a4704
   Posnack NG, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0121927
   Posnack NG, 2011, TOXICOLOGY, V279, P54, DOI 10.1016/j.tox.2010.09.007
   Prasad B, 2021, ENVIRON SCI-PROC IMP, V23, P389, DOI [10.1039/d0em00396d, 10.1039/D0EM00396D]
   Preau JL, 2010, ENVIRON HEALTH PERSP, V118, P1748, DOI 10.1289/ehp.1002231
   Processing E., 2019, EFSA J, V17
   Rashid H, 2020, ENDOCR METAB IMMUNE, V20, P633, DOI 10.2174/1871530319666191022100141
   Rifai N, 2001, CLIN CHEM, V47, P403
   Robledo CA, 2015, INT J HYG ENVIR HEAL, V218, P324, DOI 10.1016/j.ijheh.2015.01.005
   Rodríguez-Carmona Y, 2019, ENVIRON RES, V169, P26, DOI 10.1016/j.envres.2018.10.014
   Rolfo A, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061744
   Rudel RA, 2011, ENVIRON HEALTH PERSP, V119, P914, DOI 10.1289/ehp.1003170
   Ruiz D, 2018, DIABETES CARE, V41, P193, DOI 10.2337/dc16-2765
   Schaftenaar F, 2016, CURR OPIN LIPIDOL, V27, P209, DOI 10.1097/MOL.0000000000000302
   Shaffer RM, 2019, ENVIRON INT, V123, P588, DOI 10.1016/j.envint.2018.12.021
   Shang JJ, 2019, TOXICOL SCI, V168, P78, DOI 10.1093/toxsci/kfy276
   Shapiro GD, 2015, ENVIRON INT, V83, P63, DOI 10.1016/j.envint.2015.05.016
   Shim YH, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16040671
   Shiue I, 2013, EUR J NEUROL, V20, P728, DOI 10.1111/j.1468-1331.2012.03862.x
   Shiue I, 2015, ENVIRON SCI POLLUT R, V22, P1299, DOI 10.1007/s11356-014-3468-5
   Shoaff J, 2017, ENVIRON HEALTH PERSP, V125, DOI 10.1289/EHP1022
   Silva CCV, 2021, OBESITY, V29, P409, DOI 10.1002/oby.23082
   Silva MJ, 2005, ARCH TOXICOL, V79, P647, DOI 10.1007/s00204-005-0674-4
   Sol CM, 2020, ENVIRON INT, V144, DOI 10.1016/j.envint.2020.106063
   Sol CM, 2020, ENVIRON INT, V138, DOI 10.1016/j.envint.2020.105677
   Song B, 2015, INT J CLIN EXP MED, V8, P13195
   Song JW, 2010, PLAST RECONSTR SURG, V126, P2234, DOI 10.1097/PRS.0b013e3181f44abc
   Soomro MH, 2021, J GYNECOL OBSTET HUM, V50, DOI 10.1016/j.jogoh.2021.102216
   Su TC, 2019, ENVIRON POLLUT, V250, P586, DOI 10.1016/j.envpol.2019.04.006
   Su TC, 2019, ECOTOX ENVIRON SAFE, V173, P37, DOI 10.1016/j.ecoenv.2019.02.021
   Sun Q, 2014, ENVIRON HEALTH PERSP, V122, P616, DOI 10.1289/ehp.1307201
   Sutton ALM, 2018, OBSTET GYN CLIN N AM, V45, P333, DOI 10.1016/j.ogc.2018.01.012
   Svensson K, 2011, ENVIRON RES, V111, P792, DOI 10.1016/j.envres.2011.05.015
   Svoboda LK, 2020, EPIGENETICS INSIGHTS, V13, DOI 10.1177/2516865720939971
   Tran V, 2017, J DEV ORIG HLTH DIS, V8, P196, DOI [10.1017/S2040174416000763, 10.1017/s2040174416000763]
   Tranfo G., 2014, Journal of Environmental Protection, V05, P1411, DOI DOI 10.4236/JEP.2014.514135
   Trasande L, 2022, ENVIRON POLLUT, V292, DOI 10.1016/j.envpol.2021.118021
   Trasande L, 2015, HYPERTENSION, V66, P301, DOI 10.1161/HYPERTENSIONAHA.115.05603
   Tsatsakis A.M., 2019, ENCY ENV HLTH, P163, DOI DOI 10.1016/B978-0-12-409548-9.11434-4
   Tsochatzis ED, 2017, CRIT REV ANAL CHEM, V47, P279, DOI 10.1080/10408347.2016.1273754
   Vafeiadi M, 2018, FRONT PUBLIC HEALTH, V6, DOI 10.3389/fpubh.2018.00327
   Valvi D, 2015, ENVIRON HEALTH PERSP, V123, P1022, DOI 10.1289/ehp.1408887
   van der Meer TP, 2021, ENVIRON RES, V192, DOI 10.1016/j.envres.2020.110262
   van der Meer TP, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-66284-3
   Vrijheid Martine, 2020, Environ Health Perspect, V128, P67009, DOI 10.1289/EHP5975
   Vuong AM, 2021, ENVIRON INT, V156, DOI 10.1016/j.envint.2021.106747
   Wang YX, 2016, ENVIRON POLLUT, V211, P173, DOI 10.1016/j.envpol.2015.12.052
   Wang YD, 2020, ENVIRON POLLUT, V264, DOI 10.1016/j.envpol.2020.114723
   Wang Y, 2019, TOXICS, V7, DOI 10.3390/toxics7020021
   Wang ZZ, 2021, J APPL TOXICOL, V41, P618, DOI 10.1002/jat.4070
   Warembourg C, 2019, J AM COLL CARDIOL, V74, P1317, DOI 10.1016/j.jacc.2019.06.069
   Warembourg C, 2019, INT J HYG ENVIR HEAL, V222, P446, DOI 10.1016/j.ijheh.2018.12.011
   Werner EF, 2015, ENVIRON HEALTH-GLOB, V14, DOI 10.1186/s12940-015-0062-3
   WHO (World Health Organization), 2021, Obesity and overweight
   Wiberg B, 2014, ENVIRON RES, V133, P348, DOI 10.1016/j.envres.2014.06.009
   Wu HT, 2021, ENVIRON HEALTH PERSP, V129, DOI 10.1289/EHP8562
   Wu HT, 2021, ENVIRON INT, V155, DOI 10.1016/j.envint.2021.106612
   Xia B, 2018, ENVIRON INT, V121, P159, DOI 10.1016/j.envint.2018.09.001
   Yamaguchi R, 2019, AM J MED SCI, V357, P492, DOI 10.1016/j.amjms.2019.02.012
   Yao Y, 2020, ENVIRON INT, V143, DOI 10.1016/j.envint.2020.105958
   Zakai NA, 2017, THROMB HAEMOSTASIS, V117, P618, DOI 10.1160/TH16-07-0519
   Zamora AN, 2021, FRONT PUBLIC HEALTH, V9, DOI 10.3389/fpubh.2021.620769
   Zeng GW, 2022, ENVIRON HEALTH-GLOB, V21, DOI 10.1186/s12940-022-00841-3
   Zettergren A, 2021, ENVIRON RES, V192, DOI 10.1016/j.envres.2020.110249
   Zhang HJ, 2021, ENVIRON SCI POLLUT R, V28, P58113, DOI 10.1007/s11356-021-14807-4
   Zhang SH, 2018, ENVIRON SCI POLLUT R, V25, P15934, DOI 10.1007/s11356-018-1845-1
   Zhang W, 2017, TOXICOL APPL PHARM, V316, P17, DOI 10.1016/j.taap.2016.12.010
   Zhang YW, 2018, SCI TOTAL ENVIRON, V613, P1573, DOI 10.1016/j.scitotenv.2017.08.319
   Zhang YH, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0104852
   Zhang YQ, 2019, ENVIRON INT, V123, P325, DOI 10.1016/j.envint.2018.11.076
   Zukin H, 2021, ENVIRON RES, V194, DOI 10.1016/j.envres.2021.110712
NR 184
TC 61
Z9 66
U1 17
U2 66
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0304-3894
EI 1873-3336
J9 J HAZARD MATER
JI J. Hazard. Mater.
PD SEP 5
PY 2023
VL 457
AR 131680
DI 10.1016/j.jhazmat.2023.131680
EA JUN 2023
PG 21
WC Engineering, Environmental; Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Environmental Sciences & Ecology
GA K0OL0
UT WOS:001013526800001
PM 37269565
OA hybrid
DA 2025-06-11
ER

PT J
AU Sarafidis, PA
   Bakris, GL
AF Sarafidis, Pantelis A.
   Bakris, George L.
TI The antinatriuretic effect of insulin: An unappreciated mechanism for
   hypertension associated with insulin resistance?
SO AMERICAN JOURNAL OF NEPHROLOGY
LA English
DT Review
DE insulin; sodium retention; insulin resistance; hyperinsulinemia; salt
   sensitivity; oxidative stress
ID SALT-SENSITIVE HYPERTENSION; BLOOD-PRESSURE RESPONSE; ANGIOTENSINOGEN
   GENE-EXPRESSION; CARDIOVASCULAR RISK-FACTORS; DIETARY-SODIUM CHLORIDE;
   PROTEIN-KINASE PATHWAY; PROXIMAL TUBULAR CELLS; SMOOTH-MUSCLE-CELLS;
   OXIDATIVE STRESS; RENAL SODIUM
AB Insulin resistance is proposed to be causally related to the metabolic syndrome disorders, but a direct cause-and-effect relationship between insulin resistance and hypertension was not originally obvious. Previous data suggested that insulin promotes sodium retention from the kidney, and thus research efforts focused on this action among several other possible pathways connecting insulin resistance and hyperinsulinemia with hypertension. A review of numerous studies provides evidence that this antinatriuretic effect of insulin is preserved in states of metabolic insulin resistance, representing a major mechanism for blood pressure elevation. More recent experimental and clinical studies have added data about the exact tubular sites of this insulin action, its relation with the respective insulin action on potassium handling, its possible role in the development of salt sensitivity in essential hypertension, as well as the involvement of oxidant stress in these associations. This review summarizes the current state of knowledge in this area and attempts to highlight an important but rather overlooked pathway for hypertension development in the metabolic syndrome, the influence of high insulin levels leading to volume expansion. Copyright (c) 2007 S. Karger AG, Basel.
C1 Aristotle Univ Thessaloniki, Dept Med 1, AHEPA Hosp, GR-54066 Thessaloniki, Greece.
   Univ Chicago, Dept Med, Div Endocrine, Hypertens Ctr, Chicago, IL 60637 USA.
C3 Aristotle University of Thessaloniki; Ahepa University Hospital;
   University of Chicago
RP Sarafidis, PA (corresponding author), Aristotle Univ Thessaloniki, Dept Med 1, AHEPA Hosp, St Kiriakidi 1, GR-54066 Thessaloniki, Greece.
EM psarafidis11@yahoo.gr
RI Bakris, George/AFC-1168-2022; Sarafidis, Pantelis/AFO-2131-2022
OI Sarafidis, Pantelis/0000-0002-9174-4018
CR [Anonymous], CLIN HYPERTENSION
   BANK N, 1990, J CLIN INVEST, V86, P309, DOI 10.1172/JCI114700
   BAUM M, 1987, J CLIN INVEST, V79, P1104, DOI 10.1172/JCI112925
   Bayorh MA, 2004, AM J HYPERTENS, V17, P31, DOI 10.1016/j.amjhyper.2003.08.003
   Bigazzi R, 1996, AM J HYPERTENS, V9, P24, DOI 10.1016/0895-7061(95)00268-5
   BUTLEN D, 1988, PFLUG ARCH EUR J PHY, V412, P604, DOI 10.1007/BF00583761
   Ceriello A, 2000, METABOLISM, V49, P27, DOI 10.1016/S0026-0495(00)80082-7
   Chen X, 2001, ENDOCRINOLOGY, V142, P2577, DOI 10.1210/en.142.6.2577
   COSTEROUSSE O, 1993, BIOCHEM J, V290, P33, DOI 10.1042/bj2900033
   DEFRONZO RA, 1976, J CLIN INVEST, V58, P83, DOI 10.1172/JCI108463
   DEFRONZO RA, 1991, DIABETES CARE, V14, P173, DOI 10.2337/diacare.14.3.173
   DEFRONZO RA, 1981, DIABETOLOGIA, V21, P165, DOI 10.1007/BF00252649
   DEFRONZO RA, 1975, J CLIN INVEST, V55, P845, DOI 10.1172/JCI107996
   delaSierra A, 1996, CLIN SCI, V91, P155, DOI 10.1042/cs0910155
   Dengel DR, 1998, AM J PHYSIOL-ENDOC M, V274, pE403, DOI 10.1152/ajpendo.1998.274.3.E403
   EGAN BM, 1994, HYPERTENSION S1, V23, P1
   Facchini FS, 2000, AM J CLIN NUTR, V72, P776
   Ferrannini E, 1999, EUR J CLIN INVEST, V29, P842
   FERRI C, 1994, DIABETOLOGIA, V37, P308, DOI 10.1007/BF00398059
   FIDELMAN ML, 1982, AM J PHYSIOL, V242, pC121, DOI 10.1152/ajpcell.1982.242.1.C121
   FINCH D, 1990, HYPERTENSION, V15, P514, DOI 10.1161/01.HYP.15.5.514
   FRIEDBERG CE, 1991, KIDNEY INT, V40, P251, DOI 10.1038/ki.1991.207
   Fuenmayor N, 1998, AM J HYPERTENS, V11, P397, DOI 10.1016/S0895-7061(97)00490-1
   Galletti F, 1997, AM J HYPERTENS, V10, P462
   Giner V, 2000, HYPERTENSION, V35, P512, DOI 10.1161/01.HYP.35.1.512
   Giner V, 2001, J HUM HYPERTENS, V15, P481, DOI 10.1038/sj.jhh.1001216
   GUYTON AC, 1992, HYPERTENSION, V19, pI2, DOI 10.1161/01.HYP.19.1_Suppl.I2
   HAFFNER SM, 1993, J CLIN ENDOCR METAB, V76, P541, DOI 10.1210/jc.76.3.541
   HALL JE, 1991, AM J PHYSIOL, V260, pF663, DOI 10.1152/ajprenal.1991.260.5.F663
   HAMMERMAN MR, 1985, AM J PHYSIOL, V249, pF1, DOI 10.1152/ajprenal.1985.249.1.F1
   HANNEDOUCHE TP, 1990, KIDNEY INT, V37, P1126, DOI 10.1038/ki.1990.95
   Hansen LL, 1999, J BIOL CHEM, V274, P25078, DOI 10.1074/jbc.274.35.25078
   Harte AL, 2003, DIABETES OBES METAB, V5, P462, DOI 10.1046/j.1463-1326.2003.00274.x
   Hayden MR, 2005, AM J NEPHROL, V25, P553, DOI 10.1159/000088810
   IWAOKA T, 1994, AM J HYPERTENS, V7, P460, DOI 10.1093/ajh/7.5.460
   JAMERSON KA, 1993, HYPERTENSION, V21, P618, DOI 10.1161/01.HYP.21.5.618
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   Kamide K, 2000, J HYPERTENS, V18, P1051, DOI 10.1097/00004872-200018080-00009
   Kashiwagi A, 1999, AM J PHYSIOL-ENDOC M, V277, pE976, DOI 10.1152/ajpendo.1999.277.6.E976
   KIRCHNER KA, 1988, AM J PHYSIOL, V255, pF1206, DOI 10.1152/ajprenal.1988.255.6.F1206
   Kitiyakara C, 2003, J AM SOC NEPHROL, V14, P2775, DOI 10.1097/01.ASN.0000092145.90389.65
   KRIEGERBRAUER HI, 1992, J CLIN INVEST, V89, P1006, DOI 10.1172/JCI115641
   Kuroda S, 1999, J HUM HYPERTENS, V13, P257, DOI 10.1038/sj.jhh.1000800
   Laffer CL, 2006, HYPERTENSION, V47, P434, DOI 10.1161/01.HYP.0000202480.06735.82
   Laight DW, 1999, EUR J PHARMACOL, V377, P89, DOI 10.1016/S0014-2999(99)00407-0
   Landsberg L, 2001, J HYPERTENS, V19, P523, DOI 10.1097/00004872-200103001-00001
   LEMBO G, 1994, AM J PHYSIOL, V266, pE242, DOI 10.1152/ajpendo.1994.266.2.E242
   LIND L, 1992, AM J HYPERTENS, V5, P502, DOI 10.1093/ajh/5.8.502
   Meng SM, 2003, HYPERTENSION, V41, P1346, DOI 10.1161/01.HYP.0000070028.99408.E8
   Meng SM, 2002, AM J PHYSIOL-REG I, V283, pR732, DOI 10.1152/ajpregu.00346.2001
   MILLER JH, 1954, J APPL PHYSIOL, V6, P509, DOI 10.1152/jappl.1954.6.8.509
   Muscelli E, 1996, AM J HYPERTENS, V9, P746, DOI 10.1016/0895-7061(96)00098-2
   NATALI A, 1993, CLIN SCI, V85, P327, DOI 10.1042/cs0850327
   Navar LG, 2002, HYPERTENSION, V39, P316, DOI 10.1161/hy0202.103821
   Nishiyama A, 2002, J AM SOC NEPHROL, V13, DOI 10.1097/01.ASN.0000026610.48842.CB
   NIZET A, 1971, PFLUG ARCH EUR J PHY, V323, P11, DOI 10.1007/BF00586561
   NOSADINI R, 1993, KIDNEY INT, V44, P139, DOI 10.1038/ki.1993.224
   Ogihara T, 2002, HYPERTENSION, V40, P872, DOI 10.1161/01.HYP.0000040262.48405.A8
   Park JB, 2002, AM J HYPERTENS, V15, P78, DOI 10.1016/S0895-7061(01)02233-6
   Pearce D, 2001, TRENDS ENDOCRIN MET, V12, P341, DOI 10.1016/S1043-2760(01)00439-8
   Pedersen O, 1999, EXP CLIN ENDOCR DIAB, V107, P113, DOI 10.1055/s-0029-1212085
   Quinones Galvan Alfredo, 1995, American Journal of Physiology, V268, pE1
   QuinonesGalvan A, 1997, J NEPHROL, V10, P188
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   ROCCHINI AP, 1989, HYPERTENSION, V14, P367, DOI 10.1161/01.HYP.14.4.367
   Rocchini AP, 2002, AM J HYPERTENS, V15, p50S, DOI 10.1016/S0895-7061(01)02299-3
   ROCCHINI AP, 1987, HYPERTENSION, V9, P64
   ROCCHINI AP, 1989, NEW ENGL J MED, V321, P580, DOI 10.1056/NEJM198908313210905
   Rocchini AP, 2000, NUTR METAB CARDIOVAS, V10, P287
   ROCCHINI AP, 1990, HYPERTENSION, V15, P861, DOI 10.1161/01.HYP.15.6.861
   Rodríguez-Iturbe B, 2004, AM J PHYSIOL-RENAL, V286, pF606, DOI 10.1152/ajprenal.00269.2003
   Rodriguez-Iturbe B, 2002, J HYPERTENS, V20, pS9
   Rodríguez-Iturbe B, 2002, AM J PHYSIOL-RENAL, V282, pF191, DOI 10.1152/ajprenal.0197.2001
   Rudich A, 1997, AM J PHYSIOL-ENDOC M, V272, pE935, DOI 10.1152/ajpendo.1997.272.5.E935
   Rudich A, 1998, DIABETES, V47, P1562, DOI 10.2337/diabetes.47.10.1562
   Sarafidis PA, 2006, AM J HYPERTENS, V19, P646, DOI 10.1016/j.amjhyper.2005.12.017
   Sarafidis PA, 2006, AM J NEPHROL, V26, P232, DOI 10.1159/000093632
   Sartori C, 1999, J HYPERTENS, V17, P1517, DOI 10.1097/00004872-199917110-00003
   Schnackenberg CG, 2002, AM J PHYSIOL-REG I, V282, pR335, DOI 10.1152/ajpregu.00605.2001
   Schnackenberg CG, 2000, AM J PHYSIOL-RENAL, V279, pF302, DOI 10.1152/ajprenal.2000.279.2.F302
   Sechi LA, 1999, J HYPERTENS, V17, P1229, DOI 10.1097/00004872-199917090-00001
   SECHI LA, 1994, AM J PHYSIOL, V266, pF31, DOI 10.1152/ajprenal.1994.266.1.F31
   Sharma A M, 1996, Blood Press Suppl, V1, P59
   SHARMA AM, 1991, J HYPERTENS, V9, P329, DOI 10.1097/00004872-199104000-00004
   SHARMA AM, 1993, HYPERTENSION, V21, P273, DOI 10.1161/01.HYP.21.3.273
   SKOTT P, 1989, DIABETOLOGIA, V32, P694
   STENVINKEL P, 1992, DIABETOLOGIA, V35, P1042, DOI 10.1007/BF02221679
   ter Maaten JC, 2001, J HYPERTENS, V19, P1633, DOI 10.1097/00004872-200109000-00016
   ter Maaten JC, 1999, EUR J CLIN INVEST, V29, P189
   Tirosh A, 1999, J BIOL CHEM, V274, P10595, DOI 10.1074/jbc.274.15.10595
   TOMIYAMA H, 1992, HYPERTENSION, V20, P596, DOI 10.1161/01.HYP.20.5.596
   Trolliet MR, 2001, KIDNEY BLOOD PRESS R, V24, P116, DOI 10.1159/000054217
   Tuck ML, 2004, J HYPERTENS, V22, P1779, DOI 10.1097/00004872-200409000-00023
   Wilcox CS, 2005, AM J PHYSIOL-REG I, V289, pR913, DOI 10.1152/ajpregu.00250.2005
   Wilcox CS, 2005, AM J PHYSIOL-HEART C, V288, pH3, DOI 10.1152/ajpheart.00854.2004
   Xu L, 1999, HORM METAB RES, V31, P278, DOI 10.1055/s-2007-978733
   ZAVARONI I, 1995, AM J HYPERTENS, V8, P855, DOI 10.1016/0895-7061(95)00152-F
   Zhang JJ, 2004, KIDNEY INT, V66, P722, DOI 10.1111/j.1523-1755.2004.00794.x
   Zhang SL, 2002, J ENDOCRINOL, V172, P333, DOI 10.1677/joe.0.1720333
   Zhang SL, 1999, ENDOCRINOLOGY, V140, P5285, DOI 10.1210/en.140.11.5285
   Zou AP, 2001, HYPERTENSION, V37, P547, DOI 10.1161/01.HYP.37.2.547
NR 101
TC 62
Z9 66
U1 0
U2 3
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-8095
J9 AM J NEPHROL
JI Am. J. Nephrol.
PY 2007
VL 27
IS 1
BP 44
EP 54
DI 10.1159/000098955
PG 11
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 136XC
UT WOS:000244256400007
PM 17245074
DA 2025-06-11
ER

PT J
AU Rice, AJ
   Schvey, NA
   Shank, LM
   Neyland, MKH
   Lavender, JM
   Solomon, S
   Hennigan, K
   Schindler, R
   Sbrocco, T
   Jorgensen, S
   Stephens, M
   Haigney, M
   Klein, DA
   Quinlan, J
   Yanovski, JA
   Tanofsky-Kraff, M
AF Rice, Alexander J.
   Schvey, Natasha A.
   Shank, Lisa M.
   Neyland, M. K. Higgins
   Lavender, Jason M.
   Solomon, Senait
   Hennigan, Kathrin
   Schindler, Rachel
   Sbrocco, Tracy
   Jorgensen, Sarah
   Stephens, Mark
   Haigney, Mark
   Klein, David A.
   Quinlan, Jeffrey
   Yanovski, Jack A.
   Tanofsky-Kraff, Marian
TI Weight-Based Teasing and Metabolic Syndrome Components among Adolescent
   Military Dependents at Risk for Adult Obesity
SO CHILDHOOD OBESITY
LA English
DT Article
DE adolescents; metabolic syndrome; military; obesity; overweight;
   weight-based teasing
ID BULLYING VICTIMIZATION; BIAS INTERNALIZATION; STIGMA; CHILDHOOD;
   OVERWEIGHT; HEALTH; DISCRIMINATION; EXPERIENCES; CORTISOL; CHILDREN
AB Background: Among adults, weight stigma is associated with markers of poor cardiometabolic health. Although weight-based teasing (WBT) is common among youth with high body weight, few studies have examined its associations with cardiometabolic markers. Owing to unique stressors (e.g., parental deployment and frequent moves), military-dependent youth may be at particularly high risk for obesity, WBT, and poor cardiometabolic health. We, therefore, assessed associations between WBT and cardiometabolic health markers among adolescent military dependents presenting for a weight gain prevention trial.
   Methods: Participants underwent fasting phlebotomy; had fasting weight, height, and waist circumference measured; and completed assessments of WBT, anxiety, and loss-of-control eating. Multivariate analysis of covariance, adjusting for relevant covariates including demographics and body composition, was used to examine differences in metabolic syndrome (MetS) components (waist circumference, systolic and diastolic blood pressure, high-density lipoprotein cholesterol, triglycerides, and glucose) between youth reporting WBT and youth reporting no WBT. Bootstrapped models examined whether WBT mediated the relationship between BMIz and MetS components.
   Results: Data from 142 youth (57.7% female; 14.4 +/- 1.6 years; 51.2% non-Hispanic White, 20.9% non-Hispanic Black; BMIz: 1.9 +/- 0.4) were analyzed. WBT was not significantly associated with any MetS component. Relationships were observed between BMIz and all MetS components (except systolic blood pressure and glucose), although WBT did not significantly mediate these relationships (p's > 0.05).
   Conclusions: This study did not find support for a relationship between WBT and MetS components in adolescent military dependents at risk for adult obesity. Prospective research is needed to determine whether associations between WBT and adverse cardiometabolic outcomes emerge primarily in adulthood.
C1 [Rice, Alexander J.; Shank, Lisa M.; Neyland, M. K. Higgins; Lavender, Jason M.; Hennigan, Kathrin; Schindler, Rachel; Haigney, Mark; Tanofsky-Kraff, Marian] Uniformed Serv Univ Hlth Sci, Dept Med, Room A3060, Bethesda, MD 20814 USA.
   [Rice, Alexander J.; Shank, Lisa M.; Neyland, M. K. Higgins; Lavender, Jason M.; Solomon, Senait; Hennigan, Kathrin; Schindler, Rachel; Haigney, Mark; Tanofsky-Kraff, Marian] Uniformed Serv Univ Hlth Sci, Mil Cardiovasc Outcomes Res MiCOR Program, Bethesda, MD 20814 USA.
   [Rice, Alexander J.; Shank, Lisa M.; Neyland, M. K. Higgins; Lavender, Jason M.; Hennigan, Kathrin; Schindler, Rachel] Metis Fdn, San Antonio, TX USA.
   [Schvey, Natasha A.; Shank, Lisa M.; Solomon, Senait; Sbrocco, Tracy; Tanofsky-Kraff, Marian] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
   [Schvey, Natasha A.; Shank, Lisa M.; Yanovski, Jack A.; Tanofsky-Kraff, Marian] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Growth & Obes, Div Intramural Res, NIH,DHHS, Bethesda, MD USA.
   [Solomon, Senait] Henry M Jackson Fdn Adv Mil Med HJF, Bethesda, MD USA.
   [Jorgensen, Sarah] Ft Belvoir Community Hosp, Ft Belvoir, VA USA.
   [Stephens, Mark] Penn State Univ, State Coll, PA USA.
   [Klein, David A.; Quinlan, Jeffrey] Uniformed Serv Univ Hlth Sci, Dept Family Med, Bethesda, MD 20814 USA.
   [Klein, David A.] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA.
C3 Uniformed Services University of the Health Sciences - USA; Uniformed
   Services University of the Health Sciences - USA; Uniformed Services
   University of the Health Sciences - USA; National Institutes of Health
   (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child
   Health & Human Development (NICHD); Division of Intramural Research
   (DIR); Henry M. Jackson Foundation for the Advancement of Military
   Medicine, Inc; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); Pennsylvania State University; Pennsylvania State University -
   University Park; Uniformed Services University of the Health Sciences -
   USA; Uniformed Services University of the Health Sciences - USA
RP Schvey, NA (corresponding author), Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM natasha.schvey@usuhs.edu
RI Stephens, Mark/A-2679-2015; Shank, Lisa/I-7079-2015
OI , Mark/0000-0003-0156-1638; Jorgensen, Sarah/0000-0003-4167-4688;
   Quinlan, Jeffrey/0000-0001-9335-6820; Rice,
   Alexander/0009-0003-9902-807X; Haigney, Mark/0000-0001-6449-4386;
   Yanovski, Jack/0000-0001-8542-1637
FU NIDDK [1R01DK104115-01]; Defense Health Agency [MED 83-10180]; Eunice
   Kennedy Shriver National Institute of Child Health and Human Development
   [ZIA-HD-00641]
FX This research was supported by NIDDK 1R01DK104115-01 to M.T.-K., and the
   Defense Health Agency, MED 83-10180 to M.H. J.A.Y. is supported by the
   Intramural Research Program, Eunice Kennedy Shriver National Institute
   of Child Health and Human Development, ZIA-HD-00641.
CR Aboujaoude E, 2015, J ADOLESCENT HEALTH, V57, P10, DOI 10.1016/j.jadohealth.2015.04.011
   Agudelo GM, 2014, METAB SYNDR RELAT D, V12, P202, DOI 10.1089/met.2013.0127
   Andersen LG, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0014126
   Baker JL, 2007, NEW ENGL J MED, V357, P2329, DOI 10.1056/NEJMoa072515
   Bowes L, 2010, J CHILD PSYCHOL PSYC, V51, P809, DOI 10.1111/j.1469-7610.2010.02216.x
   Butte NF, 2005, PEDIATR RES, V58, P1243, DOI 10.1203/01.pdr.0000185272.46705.18
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Copeland WE, 2014, P NATL ACAD SCI USA, V111, P7570, DOI 10.1073/pnas.1323641111
   Creech SK, 2014, PROF PSYCHOL-RES PR, V45, P452, DOI 10.1037/a0035055
   Eisenberg ME, 2006, J ADOLESCENT HEALTH, V38, P675, DOI 10.1016/j.jadohealth.2005.07.002
   Fairburn Christopher G., 1993, P317
   Goldfield G, 2010, PAED CHILD HEALT-CAN, V15, P283, DOI 10.1093/pch/15.5.283
   Greenleaf C, 2014, J SCHOOL HEALTH, V84, P49, DOI 10.1111/josh.12118
   Gustafson JK, 2009, J CLIN ENDOCR METAB, V94, P4828, DOI 10.1210/jc.2008-2665
   Hannon TS, 2006, PEDIATR RES, V60, P759, DOI 10.1203/01.pdr.0000246097.73031.27
   Hayden-Wade HA, 2005, OBES RES, V13, P1381, DOI 10.1038/oby.2005.167
   Hayes A. F., 2017, INTRO MEDIATION MODE
   Neyland MKH, 2020, INT J EAT DISORDER, V53, P201, DOI 10.1002/eat.23180
   Hilbert A, 2014, OBESITY, V22, P79, DOI 10.1002/oby.20561
   Hilbert A, 2013, J ABNORM PSYCHOL, V122, P684, DOI 10.1037/a0033330
   Himmelstein MS, 2015, OBESITY, V23, P368, DOI 10.1002/oby.20959
   Hughes K, 2017, LANCET PUBLIC HEALTH, V2, pE356, DOI 10.1016/S2468-2667(17)30118-4
   Hunger JM, 2015, SOC PERSONAL PSYCHOL, V9, P255, DOI 10.1111/spc3.12172
   Jackson SE, 2018, PSYCHONEUROENDOCRINO, V98, P67, DOI 10.1016/j.psyneuen.2018.08.018
   Johnson W, 2019, INT J OBESITY, V43, P1578, DOI 10.1038/s41366-018-0192-0
   Kaeppler C, 2020, CHILD YOUTH CARE FOR, V49, P581, DOI 10.1007/s10566-020-09544-7
   Kleykamp MA, 2006, SOC SCI QUART, V87, P272, DOI 10.1111/j.1540-6237.2006.00380.x
   Kuczmarski RJ, 2002, Advance Data, V11, P1
   Kuk JL, 2018, CLIN OBES, V8, P305, DOI 10.1111/cob.12263
   Lampard AM, 2014, J YOUTH ADOLESCENCE, V43, P1770, DOI 10.1007/s10964-013-0086-3
   Libbey HP, 2008, OBESITY, V16, pS24, DOI 10.1038/oby.2008.455
   Major B, 2014, J EXP SOC PSYCHOL, V51, P74, DOI 10.1016/j.jesp.2013.11.009
   Matthews KA, 2017, PSYCHOL SCI, V28, P808, DOI 10.1177/0956797617697700
   Muennig P, 2008, BMC PUBLIC HEALTH, V8, DOI 10.1186/1471-2458-8-128
   Nicosia N, 2017, PUBLIC HEALTH REP, V132, P93, DOI 10.1177/0033354916679995
   O'Brien KS, 2016, APPETITE, V102, P70, DOI 10.1016/j.appet.2016.02.032
   O'Neal CW, 2018, J CHILD FAM STUD, V27, P3250, DOI 10.1007/s10826-018-1149-6
   Park N, 2011, AM PSYCHOL, V66, P65, DOI 10.1037/a0021249
   Pearlman AT, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17010024
   Pont SJ, 2017, PEDIATRICS, V140, DOI 10.1542/peds.2017-3034
   Puhl R., 2002, Eating disorders and obesity: A comprehensive handbook, V2nd, P108
   Puhl R, 2015, CURR OBES REP, V4, P182, DOI 10.1007/s13679-015-0153-z
   Puhl RM, 2017, PREV MED, V100, P173, DOI 10.1016/j.ypmed.2017.04.023
   Puhl RM, 2012, J YOUTH ADOLESCENCE, V41, P27, DOI 10.1007/s10964-011-9713-z
   Puhl RM, 2011, J SCHOOL HEALTH, V81, P696, DOI 10.1111/j.1746-1561.2011.00646.x
   Sapouna M, 2013, CHILD ABUSE NEGLECT, V37, P997, DOI 10.1016/j.chiabu.2013.05.009
   Schvey N.A., 2017, STIGMA HEALTH, V2, P281, DOI [10.1037/sah0000057, DOI 10.1037/SAH0000057]
   Schvey NA, 2021, PEDIATR OBES, V16, DOI 10.1111/ijpo.12729
   Schvey NA, 2019, PEDIATR OBES, V14, DOI 10.1111/ijpo.12538
   Schvey NA, 2016, J ADOLESCENT HEALTH, V58, P104, DOI 10.1016/j.jadohealth.2015.09.010
   Schvey NA, 2015, INT J EAT DISORDER, V48, P790, DOI 10.1002/eat.22424
   Schvey NA, 2014, PSYCHOSOM MED, V76, P156, DOI 10.1097/PSY.0000000000000031
   Schvey NA, 2011, OBESITY, V19, P1957, DOI 10.1038/oby.2011.204
   Sen Y, 2008, EUR J PEDIATR, V167, P1183, DOI 10.1007/s00431-007-0658-x
   Sonneville KR, 2013, JAMA PEDIATR, V167, P149, DOI 10.1001/2013.jamapediatrics.12
   Spahlholz J, 2016, OBES REV, V17, P43, DOI 10.1111/obr.12343
   Spielberger CD, 1973, STAIC PRELIMINARY MA, pt973
   Suglia SF, 2018, CIRCULATION, V137, pE15, DOI 10.1161/CIR.0000000000000536
   Sutin AR, 2014, OBESITY, V22, P1959, DOI 10.1002/oby.20789
   Tabachnick B. G., 2019, Using Multivariate Statistics, V7th, DOI DOI 10.1037/022267
   Takizawa R, 2015, PSYCHOL MED, V45, P2705, DOI 10.1017/S0033291715000653
   Tanofsky-Kraff M, 2012, INT J OBESITY, V36, P956, DOI 10.1038/ijo.2011.259
   Tanofsky-Kraff M, 2017, J CONSULT CLIN PSYCH, V85, P218, DOI 10.1037/ccp0000153
   Tanofsky-Kraff M, 2014, AM J CLIN NUTR, V100, P1010, DOI 10.3945/ajcn.114.092536
   Taylor NL, 2011, J ADOLESCENT RES, V26, P178, DOI 10.1177/0743558410371128
   THOMPSON JK, 1995, J PERS ASSESS, V65, P146, DOI 10.1207/s15327752jpa6501_11
   Tomiyama AJ, 2014, HEALTH PSYCHOL, V33, P862, DOI 10.1037/hea0000107
   Tsenkova VK, 2011, ANN BEHAV MED, V41, P243, DOI 10.1007/s12160-010-9238-9
   Vadiveloo M, 2017, ANN BEHAV MED, V51, P94, DOI 10.1007/s12160-016-9831-7
   van Gammeren AJ, 2008, CLIN CHEM LAB MED, V46, P863, DOI 10.1515/CCLM.2008.159
   Vartanian LR, 2008, J HEALTH PSYCHOL, V13, P131, DOI 10.1177/1359105307084318
   Waasdorp CE, 2007, MIL MED, V172, P962, DOI 10.7205/MILMED.172.9.962
   Waasdorp TE, 2018, AM J ORTHOPSYCHIAT, V88, P483, DOI 10.1037/ort0000294
NR 73
TC 1
Z9 2
U1 0
U2 7
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2153-2168
EI 2153-2176
J9 CHILD OBES
JI Child Obes.
PD MAR 1
PY 2021
VL 17
IS 2
BP 116
EP 124
DI 10.1089/chi.2020.0256
EA JAN 2021
PG 9
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA QY0AJ
UT WOS:000607615900001
PM 33434443
OA Green Published
DA 2025-06-11
ER

PT J
AU Lira, ME
   Loomis, AK
   Paciga, SA
   Lloyd, DB
   Thompson, JF
AF Lira, Maruja E.
   Loomis, A. Katrina
   Paciga, Sara A.
   Lloyd, David B.
   Thompson, John F.
TI Expression of CETP and of splice variants induces the same level of ER
   stress despite secretion efficiency differences
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE HDL-cholesterol; atherosclerosis; Alu sequence; endoplasmic reticulum;
   cholesteryl ester transfer protein
ID ESTER TRANSFER PROTEIN; ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE
   SYNDROME; HDL-CHOLESTEROL LEVELS; MESSENGER-RNA; ADIPOSE-TISSUE; TAQIB
   POLYMORPHISM; GENE; INHIBITION; DISEASE
AB The cholesteryl ester transfer protein (CETP) gene has been associated with a variety of phenotypes, including HDL-cholesterol levels and, more sporadically, with cardiovascular disease, obesity, and extreme longevity. Alterations of CETP activity levels can be caused by single-base polymorphisms as well as by alternative splicing. In addition to the previously characterized alternative splicing that skips exon 9, we found additional minor variants and characterized the activity of the resultant proteins. The novel variants skipped exon 9 sequences and inserted one of two in-frame exons from Alu-derived intronic sequences. None of the alternatively spliced variants are efficiently secreted, and co-expression of them inhibits wild-type CETP secretion. Expression of the alternative spliced variants causes an induction of genes linked to the endoplasmic reticulum (ER) stress response, including the neighboring HERPUD1 (homocysteine- and ER stress-inducible protein, ubiquitin- like domain-containing) gene. Unexpectedly, even though wild-type CETP is secreted much more efficiently than spliced variants, it induces the same degree of stress response as spliced variants, whereas a control secreted protein does not. CETP plays a complex role in modulating ER stress, with its expression inducing the response and its cholesteryl ester transfer activity and differential splicing modulating the response in other ways.-Lira, M. E., A. K. Loomis, S. A. Paciga, D. B. Lloyd, and J. F. Thompson. Expression of CETP and of splice variants induces the same level of ER stress despite secretion efficiency differences.
C1 [Lira, Maruja E.; Loomis, A. Katrina; Paciga, Sara A.; Lloyd, David B.; Thompson, John F.] Pfizer Global Res & Dev, Mol Med, Groton, CT 06340 USA.
C3 Pfizer; Pfizer USA
RP Lira, ME (corresponding author), Pfizer Global Res & Dev, Mol Med, Groton, CT 06340 USA.
EM jthompson@helicosbio.com
OI Thompson, John/0000-0001-8568-3311
CR Alonso AL, 2003, MOL CELL BIOCHEM, V245, P173, DOI 10.1023/A:1022832531473
   ARAI T, 1994, ARTERIOSCLER THROMB, V14, P1129, DOI 10.1161/01.ATV.14.7.1129
   Blencowe BJ, 2006, CELL, V126, P37, DOI 10.1016/j.cell.2006.06.023
   Boekholdt SM, 2004, CURR OPIN LIPIDOL, V15, P393, DOI 10.1097/01.mol.0000137226.54278.60
   Boekholdt SM, 2003, J LIPID RES, V44, P1080, DOI 10.1194/jlr.R200018-JLR200
   Dessí M, 1997, MOL CELL BIOCHEM, V177, P107, DOI 10.1023/A:1006823601032
   DRAYNA D, 1987, NATURE, V327, P632, DOI 10.1038/327632a0
   Gotoda T, 1997, ARTERIOSCL THROM VAS, V17, P1376, DOI 10.1161/01.ATV.17.7.1376
   Greaves KA, 2003, METABOLISM, V52, P282, DOI 10.1053/meta.2003.50045
   Gregor MF, 2007, J LIPID RES, V48, P1905, DOI 10.1194/jlr.R700007-JLR200
   Hayashibe H, 1997, ATHEROSCLEROSIS, V129, P53, DOI 10.1016/S0021-9150(96)06014-5
   Heilbronn LK, 2002, ATHEROSCLEROSIS, V162, P419, DOI 10.1016/S0021-9150(01)00733-X
   INAZU A, 1992, BIOCHEMISTRY-US, V31, P2352, DOI 10.1021/bi00123a021
   Izem L, 2007, J BIOL CHEM, V282, P21856, DOI 10.1074/jbc.M701075200
   JIANG XC, 1991, J BIOL CHEM, V266, P4631
   Klerkx AHEM, 2006, ARTERIOSCL THROM VAS, V26, P706, DOI 10.1161/01.ATV.0000205595.19612.c9
   Kokame K, 2000, J BIOL CHEM, V275, P32846, DOI 10.1074/jbc.M002063200
   Lloyd DB, 2005, J BIOL CHEM, V280, P14918, DOI 10.1074/jbc.M500523200
   MacLean PS, 2005, J CLIN ENDOCR METAB, V90, P2250, DOI 10.1210/jc.2004-1325
   Myoishi M, 2007, CIRCULATION, V116, P1226, DOI 10.1161/CIRCULATIONAHA.106.682054
   Qiu XY, 2007, NAT STRUCT MOL BIOL, V14, P106, DOI 10.1038/nsmb1197
   QUINET E, 1993, J BIOL CHEM, V268, P16891
   Radeau T, 1998, ATHEROSCLEROSIS, V139, P369, DOI 10.1016/S0021-9150(98)00051-3
   Radeau T, 1995, J LIPID RES, V36, P2552
   Sakai N, 1996, J LIPID RES, V37, P2065
   Schröder M, 2005, MUTAT RES-FUND MOL M, V569, P29, DOI 10.1016/j.mrfmmm.2004.06.056
   Sorek R, 2004, MOL CELL, V14, P221, DOI 10.1016/S1097-2765(04)00181-9
   Thompson JF, 2005, ATHEROSCLEROSIS, V181, P45, DOI 10.1016/j.atherosclerosis.2005.01.015
   Vassiliou G, 2004, J LIPID RES, V45, P1683, DOI 10.1194/jlr.M400051-JLR200
   Vohl MC, 1999, INT J OBESITY, V23, P918, DOI 10.1038/sj.ijo.0800972
   Weitgasser R, 2004, BIOMED PHARMACOTHER, V58, P619, DOI 10.1016/j.biopha.2004.09.010
NR 31
TC 19
Z9 20
U1 0
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD SEP
PY 2008
VL 49
IS 9
BP 1955
EP 1962
DI 10.1194/jlr.M800078-JLR200
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 337YX
UT WOS:000258472500011
PM 18509195
OA hybrid
DA 2025-06-11
ER

PT J
AU Delos Reyes, FSLG
   Mamaril, ACC
   Matias, TJP
   Tronco, MKV
   Samson, GR
   Javier, ND
   Fadriquela, A
   Antonio, JM
   Sajo, MEJV
AF Delos Reyes, Felippe Steven Louis G.
   Mamaril, Adrian Carlo C.
   Matias, Trisha Joy P.
   Tronco, Mary Kathleen V.
   Samson, Gabriel R.
   Javier, Nyczl D.
   Fadriquela, Ailyn
   Antonio, Jayson M.
   Sajo, Ma Easter Joy V.
TI The Search for the Elixir of Life: On the Therapeutic Potential of
   Alkaline Reduced Water in Metabolic Syndromes
SO PROCESSES
LA English
DT Review
DE metabolic syndrome; alkaline ionized water; alkaline-ionized water;
   alkaline reduced water; obesity; diabetes; cancer; non-alcoholic fatty
   liver disease; microbiota; exercise
ID HYDROGEN-RICH WATER; FATTY LIVER-DISEASE; ELECTROLYZED WATER; OXIDATIVE
   STRESS; GUT MICROBIOTA; DIABETES-MELLITUS; ADIPOSE-TISSUE;
   ANIMAL-MODELS; CANCER; HEALTH
AB Our body composition is enormously influenced by our lifestyle choices, which affect our health and longevity. Nutrition and physical activities both impact overall metabolic condition, thus, a positive energy balance causes oxidative stress and inflammation, hastening the development of metabolic syndrome. With this knowledge, boosting endogenous and exogenous antioxidants has emerged as a therapeutic strategy for combating metabolic disorders. One of the promising therapeutic inventions is the use of alkaline reduced water (ARW). Aside from its hydrating and non-caloric properties, ARW has demonstrated strong antioxidant and anti-inflammatory properties that can help stabilize physiologic turmoil caused by oxidative stress and inflammation. This review article is a synthesis of studies where we elaborate on the intra- and extracellular effects of drinking ARW, and relate these to the pathophysiology of common metabolic disorders, such as obesity, diabetes mellitus, non-alcoholic fatty liver disease, and some cancers. Highlighting the health-promoting benefits of ARW, we also emphasize the importance of maintaining a healthy lifestyle by incorporating exercise and practicing a balanced diet as forms of habit.
C1 [Delos Reyes, Felippe Steven Louis G.; Mamaril, Adrian Carlo C.; Matias, Trisha Joy P.; Tronco, Mary Kathleen V.; Samson, Gabriel R.; Javier, Nyczl D.; Antonio, Jayson M.; Sajo, Ma Easter Joy V.] Univ Philippines Baguio, Dept Biol, Coll Sci, Baguio 2600, Philippines.
   [Fadriquela, Ailyn] Yonsei Univ, Wonju Coll Med, Dept Lab Med, Wonju 26426, South Korea.
   [Antonio, Jayson M.] Yonsei Univ, Wonju Coll Med, Dept Microbiol, Wonju 26426, South Korea.
C3 University of the Philippines System; University of the Philippines
   Baguio; Yonsei University; Yonsei University
RP Sajo, MEJV (corresponding author), Univ Philippines Baguio, Dept Biol, Coll Sci, Baguio 2600, Philippines.
EM fgdelosreyes@up.edu.ph; acmamaril2@up.edu.ph; tpmatias@up.edu.ph;
   mvtronco@up.edu.ph; grsamson@up.edu.ph; ndjavier@up.edu.ph;
   ailyn@yonsei.ac.kr; fyeflowright03@gmail.com; mvsajo@up.edu.ph
RI Fadriquela, Ailyn/JEZ-2749-2023; Sajo, Ma Easter Joy/HJB-4349-2022;
   Antonio, Jayson/JAN-6264-2023
OI Delos Reyes, Felippe Steven Louis/0000-0002-2270-4055; Matias, Trisha
   Joy/0000-0001-6413-2107; Fadriquela, Ailyn/0000-0002-7860-4539; Antonio,
   Jayson/0000-0001-6855-5617; Mamaril, Adrian Carlo/0000-0002-2842-0790;
   Tronco, Mary Kathleen/0000-0003-0311-0558
CR Ahmed B, 2021, BIOMED PHARMACOTHER, V137, DOI 10.1016/j.biopha.2021.111315
   Al-Asmakh M, 2015, J MICROBIOL BIOTECHN, V25, P1583, DOI 10.4014/jmb.1501.01039
   Al-Hilu SA, 2020, INT J MICROBIOL, V2020, DOI 10.1155/2020/4639761
   Al-Maskari F., LIFESTYLE DISEASES: an economic burden on the health services
   Anand P, 2008, PHARM RES-DORDR, V25, P2097, DOI 10.1007/s11095-008-9661-9
   Angeles-Agdeppa I, 2020, NUTR J, V19, DOI 10.1186/s12937-020-00597-x
   Argilés JM, 2018, NAT REV ENDOCRINOL, V15, P9, DOI 10.1038/s41574-018-0123-0
   Aron-Wisnewsky J, 2016, NAT REV NEPHROL, V12, P169, DOI 10.1038/nrneph.2015.191
   Bäckhed F, 2005, SCIENCE, V307, P1915, DOI 10.1126/science.1104816
   Bose S, 2020, MOL CELL, V80, DOI 10.1016/j.molcel.2020.10.006
   Brauns J, 2020, PROCESSES, V8, DOI 10.3390/pr8020248
   Chaffer CL, 2011, SCIENCE, V331, P1559, DOI 10.1126/science.1203543
   Chaves VE, 2011, BIOCHIMIE, V93, P1631, DOI 10.1016/j.biochi.2011.05.018
   Chycki J, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0205708
   Chycki J, 2017, BIOL SPORT, V34, P255, DOI 10.5114/biolsport.2017.66003
   Cian C, 2001, INT J PSYCHOPHYSIOL, V42, P243, DOI 10.1016/S0167-8760(01)00142-8
   Connolly JL., 2003, HOLLAND FREI CANC ME
   Coyle EF, 2004, J SPORT SCI, V22, P39, DOI 10.1080/0264041031000140545
   de La Serre CB, 2010, AM J PHYSIOL-GASTR L, V299, pG440, DOI 10.1152/ajpgi.00098.2010
   Deen D, 2004, AM FAM PHYSICIAN, V69, P2875
   El-Zimaity H, 2018, ANN NY ACAD SCI, V1434, P319, DOI 10.1111/nyas.13858
   Forouzanfar MH, 2016, LANCET, V388, P1659, DOI 10.1016/S0140-6736(16)31679-8
   Fouad YA, 2017, AM J CANCER RES, V7, P1016
   Gevers D, 2012, PLOS BIOL, V10, DOI 10.1371/journal.pbio.1001377
   GROOP LC, 1989, J CLIN INVEST, V84, P205, DOI 10.1172/JCI114142
   Hackshaw AK, 1997, BMJ-BRIT MED J, V315, P980, DOI 10.1136/bmj.315.7114.980
   Hanahan D, 2000, CELL, V100, P57, DOI 10.1016/S0092-8674(00)81683-9
   Hansen TH, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-34761-5
   Heimann E, 2015, ADIPOCYTE, V4, P81, DOI 10.4161/21623945.2014.960694
   Henry M, 2013, WATER-SUI, V5, P2094, DOI 10.3390/w5042094
   Higashimura Y, 2018, MED GAS RES, V8, P6, DOI 10.4103/2045-9912.229597
   Huang KC, 2006, KIDNEY INT, V70, P391, DOI 10.1038/sj.ki.5001576
   Huang KC, 2003, KIDNEY INT, V64, P704, DOI 10.1046/j.1523-1755.2003.00118.x
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Huang YR, 2008, FOOD CONTROL, V19, P329, DOI 10.1016/j.foodcont.2007.08.012
   Ignacio Rosa Mistica C, 2014, J Lifestyle Med, V4, P1, DOI 10.15280/jlm.2014.4.1.1
   Ignacio RMC, 2013, BIOL PHARM BULL, V36, P1052, DOI 10.1248/bpb.b12-00781
   Iio A, 2013, MED GAS RES, V3, DOI 10.1186/2045-9912-3-6
   Inoue-Choi M, 2018, INT J CANCER, V142, P271, DOI 10.1002/ijc.31059
   Jackson K, 2018, WORLD J GASTROENTERO, V24, P5095, DOI 10.3748/wjg.v24.i45.5095
   Jia BL, 2019, PLOS PATHOG, V15, DOI 10.1371/journal.ppat.1007954
   Jin D, 2006, BIOSCI BIOTECH BIOCH, V70, P31, DOI 10.1271/bbb.70.31
   Kajiyama S, 2008, NUTR RES, V28, P137, DOI 10.1016/j.nutres.2008.01.008
   Kamimura N, 2011, OBESITY, V19, P1396, DOI 10.1038/oby.2011.6
   Karpinski TM, 2019, MICROORGANISMS, V7, DOI 10.3390/microorganisms7010020
   Kawai D, 2012, HEPATOLOGY, V56, P912, DOI 10.1002/hep.25782
   Kim JM., 1997, KOREAN J LAB ANIM SC, V13, P187
   Kim MJ, 2006, LIFE SCI, V79, P2288, DOI 10.1016/j.lfs.2006.07.027
   Kim NH, 2002, J KOREAN MED SCI, V17, P571, DOI 10.3346/jkms.2002.17.4.571
   Kim SK, 2019, MOL CELL TOXICOL, V15, P431, DOI 10.1007/s13273-019-0047-3
   Kinjo T, 2012, CYTOTECHNOLOGY, V64, P357, DOI 10.1007/s10616-012-9469-7
   Koh EJ, 2019, MOL CELL TOXICOL, V15, P1, DOI 10.1007/s13273-019-0001-4
   Koseki M, 2007, J FOOD SCI, V72, pS298, DOI 10.1111/j.1750-3841.2007.00384.x
   Kostic AD, 2013, GENE DEV, V27, P701, DOI 10.1101/gad.212522.112
   Kumar V., 2014, Robbins & Cotran Pathologic Basis of Disease (Robbins Pathology)
   Kumar V, 2017, Robbins basic pathology e-book
   Laborda-Illanes A, 2020, CANCERS, V12, DOI 10.3390/cancers12092465
   Lee AY, 2006, APPL BIOCHEM BIOTECH, V135, P133
   Lee EYHP, 2010, CSH PERSPECT BIOL, V2, DOI 10.1101/cshperspect.a003236
   Lee K.-J., 2004, J INT SOC LIFE INF S, V22, P302
   Lee K.-J, 2020, J FOOD DRUG ANAL, V20, DOI [10.38212/2224-6614.2099, DOI 10.38212/2224-6614.2099]
   Lee Kyu Jae, 2006, [Biomedical Science Letters, 대한의생명과학회지], V12, P1
   Lee Kyu Jae, 2007, [Biomedical Science Letters, 대한의생명과학회지], V13, P83
   Lee KJ, 2009, BIOL PHARM BULL, V32, P456, DOI 10.1248/bpb.32.456
   Li YP, 2011, CYTOTECHNOLOGY, V63, P119, DOI 10.1007/s10616-010-9317-6
   Lim S, 2014, REV ENDOCR METAB DIS, V15, P329, DOI 10.1007/s11154-014-9298-4
   Lindenmeyer CC, 2018, CLIN LIVER DIS, V22, P11, DOI 10.1016/j.cld.2017.08.003
   Ma C, 2018, SCIENCE, V360, DOI 10.1126/science.aan5931
   Magro M, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/3084126
   Maurizi G, 2018, J CELL PHYSIOL, V233, P88, DOI 10.1002/jcp.25855
   Mendrick DL, 2018, TOXICOL SCI, V162, P36, DOI 10.1093/toxsci/kfx233
   Miller KD, 2019, CA-CANCER J CLIN, V69, P363, DOI 10.3322/caac.21565
   Montain SJ, 2008, CURR SPORT MED REP, V7, P187, DOI 10.1249/JSR.0b013e31817f005f
   Murphy EF, 2010, GUT, V59, P1635, DOI 10.1136/gut.2010.215665
   Nagpal R, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.02897
   Nilsson PM, 2019, EUR J PREV CARDIOL, V26, P33, DOI 10.1177/2047487319886404
   O'Toole PW, 2020, J INTERN MED, V287, P271, DOI 10.1111/joim.13021
   Ostojic SM, 2014, RES SPORTS MED, V22, P49, DOI 10.1080/15438627.2013.852092
   Park J, 2017, MOL CELL TOXICOL, V13, P1, DOI 10.1007/s13273-017-0001-1
   PATE RR, 1995, JAMA-J AM MED ASSOC, V273, P402, DOI 10.1001/jama.273.5.402
   Petta S, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17122082
   Pullingr CR, 2002, J CLIN INVEST, V110, P109, DOI 10.1172/JCI200215387
   Qin JJ, 2010, NATURE, V464, P59, DOI 10.1038/nature08821
   Qureshi K, 2007, WORLD J GASTROENTERO, V13, P3540, DOI 10.3748/wjg.v13.i26.3540
   Ramadhan A, 2021, PAK J MED HEALTH SCI, V15, P1449, DOI 10.53350/pjmhs211551449
   Remig V, 2010, J AM DIET ASSOC, V110, P585, DOI 10.1016/j.jada.2009.12.024
   Rias YA, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9100946
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Sahai E, 2005, CURR OPIN GENET DEV, V15, P87, DOI 10.1016/j.gde.2004.12.002
   Sakurai T, 2011, ONCOLOGY-BASEL, V81, P24, DOI 10.1159/000333256
   Samson SL, 2014, ENDOCRIN METAB CLIN, V43, P1, DOI 10.1016/j.ecl.2013.09.009
   Schipper HS, 2012, J CLIN INVEST, V122, P3343, DOI 10.1172/JCI62739
   Scoccianti C, 2015, CANCER EPIDEMIOL, V39, pS67, DOI 10.1016/j.canep.2015.01.007
   Sharma VR, 2021, SEMIN CANCER BIOL, V70, P61, DOI 10.1016/j.semcancer.2020.07.006
   Shin DW, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/9147914
   Shirahata S, 2012, TRENDS FOOD SCI TECH, V23, P124, DOI 10.1016/j.tifs.2011.10.009
   SIEGERT CEH, 1995, AM J GASTROENTEROL, V90, P1528
   Sikaris Ken A, 2004, Clin Biochem Rev, V25, P165
   Silva YP, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00025
   Singh P., 2019, Obesity Medicine, V16, P100140, DOI DOI 10.1016/J.OBMED.2019.100140
   Siswantoro E., 2017, J Diabetes Mellitus, V7, P249, DOI [10.4236/jdm.2017.74020, DOI 10.4236/JDM.2017.74020]
   Srivastava AK, 2012, INDIAN J PHARMACOL, V44, P155, DOI 10.4103/0253-7613.93579
   Steeg PS, 2006, NAT MED, V12, P895, DOI 10.1038/nm1469
   Tanaka Y, 2021, MED GAS RES, V11, P138, DOI 10.4103/2045-9912.318858
   Tanaka Y, 2018, MED GAS RES, V8, P160, DOI 10.4103/2045-9912.248267
   Tomasetti C, 2017, SCIENCE, V355, P1330, DOI 10.1126/science.aaf9011
   Topping DL, 2001, PHYSIOL REV, V81, P1031, DOI 10.1152/physrev.2001.81.3.1031
   Vergara D, 2019, J ONCOL, V2019, DOI 10.1155/2019/1253727
   Vorobjeva NV, 2005, MED HYPOTHESES, V64, P543, DOI 10.1016/j.mehy.2004.07.038
   Wagh Arati, 2004, Expert Rev Cardiovasc Ther, V2, P213, DOI 10.1586/14779072.2.2.213
   Watanabe Toshi, 1997, Journal of Toxicological Sciences, V22, P141
   West R, 2009, COPD, V6, P277, DOI 10.1080/15412550903049181
   Wiley NC, 2017, J ANIM SCI, V95, P3225, DOI 10.2527/jas.2016.1256
   World Health Organization, Non communicable diseases
   Wu SG, 2009, NAT MED, V15, P1016, DOI 10.1038/nm.2015
   Wu S, 2016, NATURE, V529, P43, DOI 10.1038/nature16166
   Xue JL, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-81
   Yan HX, 2011, BIOSCI BIOTECH BIOCH, V75, P1295, DOI 10.1271/bbb.110072
   Ye J, 2008, BIOL PHARM BULL, V31, P19, DOI 10.1248/bpb.31.19
   Yoon YS, 2011, FOOD CHEM TOXICOL, V49, P1814, DOI 10.1016/j.fct.2011.04.033
   Yu JS, 2016, GASTROENT RES PRACT, V2016, DOI 10.1155/2016/2862173
   Zajac A, 2017, J NUTR HLTH FOOD SCI, V5, DOI [10.15226/jnhfs.2017.00194, DOI 10.15226/JNHFS.2017.00194]
   Zhai X, 2017, MOL MED REP, V15, P1305, DOI 10.3892/mmr.2017.6120
   Zhang JL, 2021, GENES DIS, V8, P581, DOI 10.1016/j.gendis.2020.08.002
NR 124
TC 11
Z9 11
U1 3
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9717
J9 PROCESSES
JI Processes
PD NOV
PY 2021
VL 9
IS 11
AR 1876
DI 10.3390/pr9111876
PG 20
WC Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA XF5MJ
UT WOS:000724113900001
OA gold
DA 2025-06-11
ER

PT J
AU Saidi, AO
   Akintayo, CO
   Atuma, CL
   Mahmud, H
   Sabinari, IW
   Oniyide, AA
   Aturamu, A
   Agunbiade, TB
   Olaniyi, KS
AF Saidi, Azeezat O.
   Akintayo, Christopher O.
   Atuma, Chukwubueze L.
   Mahmud, Hadiza
   Sabinari, Isaiah W.
   Oniyide, Adesola A.
   Aturamu, Ayodeji
   Agunbiade, Toluwani B.
   Olaniyi, Kehinde S.
TI Melatonin supplementation preserves testicular function by attenuating
   lactate production and oxidative stress in high fat diet-induced obese
   rat model
SO THERIOGENOLOGY
LA English
DT Article
DE High fat; Lactate; Melatonin; Oxidative stress; Testicular function
ID METABOLIC SYNDROME; SODIUM-ACETATE; DAMAGE; INSULIN; TESTOSTERONE;
   HOMEOSTASIS; DYSFUNCTION; EXPRESSION; GLUCOSE; PROTEIN
AB Metabolic syndrome, including obesity has been documented as a critical factor in male reproductive dysfunction with subsequent reduction in male fertility. The therapeutic potential of melatonin has been demonstrated against oxidative stress-induced pathologies. Therefore, the present study investigated the effects of melatonin on testicular dysfunction associated with high fat diet (FD)-induced obese rat model, and the possible involvement of peroxisome proliferator-activated receptor-gamma (PPAR-gamma). Adult male Wistar rats (n = 6/group) were used: control group received vehicle (normal saline), obese group received 40% FD, melatonin-treated group received melatonin (4 mg/kg), and obese plus melatonin group received melatonin and 40% FD and the treatment lasted for 12 weeks. High fat diet caused increased body weight and testicular triglyceride, total cholesterol, malondialdehyde, gamma-glutamyl transferase, lactate production and lactate/pyruvate ratio as well as decreased glutathione/glutathione peroxidase, nitric oxide and PPAR-gamma and circulating testosterone. Nevertheless, all these alterations were attenuated when supplemented with melatonin. Taken together, these results demonstrates that FD-induced obesity causes testicular dysfunction. In addition, the results suggest that melatonin supplementation protects against obesity-associated testicular dysfunction and this effect is accompanied by upregulation of PPAR-gamma. (C) 2022 Elsevier Inc. All rights reserved.
C1 [Saidi, Azeezat O.; Akintayo, Christopher O.; Atuma, Chukwubueze L.; Mahmud, Hadiza; Oniyide, Adesola A.; Aturamu, Ayodeji; Olaniyi, Kehinde S.] Afe Babalola Univ, Dept Physiol, Coll Med & Hlth Sci, Ado Ekiti 360101, Nigeria.
   [Sabinari, Isaiah W.; Olaniyi, Kehinde S.] Univ Ilorin, HOPE Cardiometabol Res Team Dept Physiol, Coll Hlth Sci, P M B, 1515, Ilorin, Nigeria.
   [Agunbiade, Toluwani B.] Afe Babalola Univ, Dept Med Microbiol, Coll Med & Hlth Sci, Ado Ekiti 360101, Nigeria.
C3 University of Ilorin
RP Olaniyi, KS (corresponding author), Afe Babalola Univ, Dept Physiol, Coll Med & Hlth Sci, Ado Ekiti 360101, Nigeria.; Olaniyi, KS (corresponding author), Univ Ilorin, HOPE Cardiometabol Res Team Dept Physiol, Coll Hlth Sci, P M B, 1515, Ilorin, Nigeria.
EM olaniyisk@abuad.edu.ng
RI Olaniyi, Kehinde/GPK-5850-2022
OI Olaniyi, Kehinde/0000-0002-8229-9688
CR Agil A, 2011, J PINEAL RES, V50, P207, DOI 10.1111/j.1600-079X.2010.00830.x
   Aitken RJ, 2014, ASIAN J ANDROL, V16, P31, DOI 10.4103/1008-682X.122203
   Akinola OB, 2015, MIDDLE EAST FERTIL S, V20, P271, DOI 10.1016/j.mefs.2015.04.003
   Allam MAM, 2022, J PHARM PHARMACOL, V74, P573, DOI 10.1093/jpp/rgab083
   Barish GD, 2006, J CLIN INVEST, V116, P590, DOI 10.1172/JCI27955
   Buettner R, 2007, OBESITY, V15, P798, DOI 10.1038/oby.2007.608
   Chabra A, 2014, HUM EXP TOXICOL, V33, P185, DOI 10.1177/0960327113489052
   Chen C, 2019, ANDROLOGIA, V51, DOI 10.1111/and.13323
   Chien D, 2000, AM J PHYSIOL-ENDOC M, V279, pE259, DOI 10.1152/ajpendo.2000.279.2.E259
   Cipolla-Neto J, 2014, J PINEAL RES, V56, P371, DOI 10.1111/jpi.12137
   Dandona P, 2011, J CLIN ENDOCR METAB, V96, P2643, DOI 10.1210/jc.2010-2724
   Donner DG, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0138019
   Duale N, 2014, ANDROLOGY-US, V2, P234, DOI 10.1111/j.2047-2927.2013.00178.x
   ELLMAN GL, 1959, ARCH BIOCHEM BIOPHYS, V82, P70, DOI 10.1016/0003-9861(59)90090-6
   Fan Y, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0120775
   Förstermann U, 2010, PFLUG ARCH EUR J PHY, V459, P923, DOI 10.1007/s00424-010-0808-2
   Gallo A, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10071131
   Gould DC, 2007, INT J CLIN PRACT, V61, P341, DOI 10.1111/j.1742-1241.2006.01239.x
   Granchi C, 2010, CURR MED CHEM, V17, P672, DOI 10.2174/092986710790416263
   Huang JC, 2008, PPAR RES, V2008, DOI 10.1155/2008/732303
   Jarvis S, 2020, INT J OBESITY, V44, P1958, DOI 10.1038/s41366-020-0595-6
   Jing J, 2020, CELL DEATH DIS, V11, DOI 10.1038/s41419-020-02751-z
   Khalil SS, 2021, CAN J PHYSIOL PHARM, V99, P708, DOI 10.1139/cjpp-2020-0499
   Michiue T, 2013, LEGAL MED-TOKYO, V15, P79, DOI 10.1016/j.legalmed.2012.09.003
   Miller M.A., 2017, Pathologic Basis of Veterinary Disease, P2, DOI DOI 10.1016/B978-0-323-35775-3.00001-1
   Montserrat A, 2018, BMC GENOMICS, V19, P1
   Musa E, 2021, PAN AFR MED J, V38, DOI 10.11604/pamj.2021.38.292.25719
   Olaniyi KS, 2021, CYTOKINE, V142, DOI 10.1016/j.cyto.2021.155501
   Olaniyi KS, 2021, BIOCHIMIE, V184, P52, DOI 10.1016/j.biochi.2021.02.004
   Olaniyi KS, 2020, NUTRITION, V77, DOI 10.1016/j.nut.2020.110789
   Ozen OA, 2008, SYST BIOL REPROD MED, V54, P169, DOI 10.1080/19396360802422402
   PASQUALI R, 1991, METABOLISM, V40, P101, DOI 10.1016/0026-0495(91)90199-7
   Paterniti I, 2017, MOL NEUROBIOL, V54, P5973, DOI 10.1007/s12035-016-0131-9
   Puchalski SS, 2003, ENDOCRINE, V21, P163, DOI 10.1385/ENDO:21:2:163
   Ríos-Lugo MJ, 2010, J PINEAL RES, V49, P342, DOI 10.1111/j.1600-079X.2010.00798.x
   Schultz R, 1999, ENDOCRINOLOGY, V140, P2968, DOI 10.1210/en.140.7.2968
   Sener G, 2003, LIFE SCI, V74, P563, DOI 10.1016/j.lfs.2003.05.011
   Shirai T, 2016, NUTR RES, V36, P262, DOI 10.1016/j.nutres.2015.11.018
   Stefater MA, 2010, GASTROENTEROLOGY, V138, P2426, DOI 10.1053/j.gastro.2010.02.059
   Tsai EC, 2004, DIABETES CARE, V27, P861, DOI 10.2337/diacare.27.4.861
   Unger RH, 2010, BBA-MOL CELL BIOL L, V1801, P209, DOI 10.1016/j.bbalip.2009.10.006
   Usman TO, 2018, J NUTR BIOCHEM, V62, P65, DOI 10.1016/j.jnutbio.2018.08.018
   Wang C, 2011, DIABETES CARE, V34, P1669, DOI 10.2337/dc10-2339
   Wang HL, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19051325
   Xu DJ, 2020, J PINEAL RES, V69, DOI 10.1111/jpi.12690
   Yaribeygi H, 2020, CRIT REV EUKAR GENE, V30, P93, DOI 10.1615/CritRevEukaryotGeneExpr.2020027918
   Yu K, 2018, MOLECULES, V23, DOI 10.3390/molecules23020447
   Zhang K, 2012, ANDROLOGIA, V44, P230, DOI 10.1111/j.1439-0272.2012.01272.x
   Zhou JF, 2008, J PINEAL RES, V45, P157, DOI 10.1111/j.1600-079X.2008.00570.x
NR 49
TC 5
Z9 5
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0093-691X
EI 1879-3231
J9 THERIOGENOLOGY
JI Theriogenology
PD JUL 15
PY 2022
VL 187
BP 19
EP 26
DI 10.1016/j.theriogenology.2022.02.029
EA APR 2022
PG 8
WC Reproductive Biology; Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Reproductive Biology; Veterinary Sciences
GA 6E1CR
UT WOS:000883122900003
PM 35500423
DA 2025-06-11
ER

PT J
AU González, CY
   Estrada, JA
   Oros-Pantoja, R
   Colín-Ferreyra, MD
   Benitez-Arciniega, AD
   Piña, AES
   Aguirre-Garrido, JF
AF Gonzalez, Cristian Yuriana
   Estrada, Jose Antonio
   Oros-Pantoja, Rigoberto
   Colin-Ferreyra, Maria del Carmen
   Benitez-Arciniega, Alejandra Donaji
   Soto Pina, Alexandra Estela
   Aguirre-Garrido, Jose Felix
TI The Gut Microbiota Is Involved in the Regulation of Cognitive
   Flexibility in Adolescent BALB/c Mice Exposed to Chronic Physical Stress
   and a High-Fat Diet
SO MICROORGANISMS
LA English
DT Article
DE attentional set-shifting test; chronic stress; cognitive flexibility;
   high-fat diet; gut microbiota; prefrontal cortex
ID RNA GENE DATABASE; METABOLIC SYNDROME; MOUSE MODEL; DISEASE; DEPRESSION;
   GREENGENES; BACTERIA; RISK
AB Dysfunction in the prefrontal cortex can lead to cognitive inflexibility due to multifactorial causes as included cardiometabolic disorders, stress, inadequate diets, as well as an imbalance of the gut-brain axis microbiota. However, these risk factors have not been evaluated jointly. The purpose of this study was to evaluate the effect of physical stress (MS: Male Stress and FS: Female Stress) and high-fat diet (MD: Male Diet and FD: Female Diet) supplementation on the gut microbiota and cognitive flexibility. Methods: The study was performed on 47 mice, 30 male (M) and 17 female (F) BALBc, exposed to chronic stress physical (S) and high-fat diet (D). Cognitive flexibility was evaluated using the Attentional Set-Shifting Test (ASST) and the gut microbiota composition in terms of relative abundance (%) and alpha-beta diversity. Results: Results showed that S and D reduced cognitive flexibility in male and female mice (p < 0.0001). Significant changes occurred in Alistipes spp. (MM vs. MS:MD; p < 0.0001), Barnesiella spp. (FC vs. FS; p = 0.0002; FC vs. FD, p = 0.0033); Dorea spp. (MC vs. MD, p = 0.0008; MM vs. MD, p < 0.0001) and Lactobacillus spp. (MC vs. MD and FM vs. FS, p < 0.0001; FM vs. MD, p = 0.0393) genera among groups. Predictive functional analysis (QIIME2 and PICRUSt2) showed a significant increase in the expression of histidine kinase, alanine dehydrogenase, glutamine synthase, glutamate synthase, arginine succinyl synthase, and tryptophan synthase genes (p < 0.05), the latter being a precursor of serotonin (5-HT). Conclusions: Chronic physical stress and a high-fat diet modify cognitive flexibility and the composition and predictive function of the gut microbiota.
C1 [Gonzalez, Cristian Yuriana; Estrada, Jose Antonio; Oros-Pantoja, Rigoberto; Colin-Ferreyra, Maria del Carmen; Benitez-Arciniega, Alejandra Donaji; Soto Pina, Alexandra Estela] Autonomous Univ State Mexico, Sch Med, Paseo Tollocan & Jesus Carranza, Toluca De Lerdo 50180, State Of Mexico, Mexico.
   [Aguirre-Garrido, Jose Felix] Autonomous Metropolitan Univ Lerma, Dept Biotechnol & Environm Microbiol, Hidalgo Pte 46, Lerma 52006, State Of Mexico, Mexico.
C3 Universidad Autonoma del Estado de Mexico
RP Piña, AES (corresponding author), Autonomous Univ State Mexico, Sch Med, Paseo Tollocan & Jesus Carranza, Toluca De Lerdo 50180, State Of Mexico, Mexico.
EM cgonzalez002@alumno.uaemex.mx; jaestradag@uaemex.mx; rorosp@uaemex.mx;
   mdcolinf@uaemex.mx; abeniteza@uaemex.mx; aesotop@uaemex.mx;
   j.aguirre@correo.ler.uam.mx
RI Fernández-González, Antonio/H-5942-2015; Oros-Pantoja,
   Rigoberto/O-1494-2019; Estrada, José/B-1500-2016; Soto,
   Alexandra/AAH-4797-2021; Oros-Pantoja, Rigoberto/B-3370-2016
OI Oros-Pantoja, Rigoberto/0000-0001-5441-0863; Aguirre Garrido, Jose
   Felix/0000-0002-4017-3753; Gonzalez, Cristian
   Yuriana/0000-0001-8285-7814; Soto Pina, Alexandra
   Estela/0000-0002-3289-5510
FU Secretaria de Investigacion y Estudios Avanzados of Universidad Autonoma
   del Estado de Mexico [6199-2020CIB]
FX This research was funded by the Secretaria de Investigacion y Estudios
   Avanzados of Universidad Autonoma del Estado de Mexico (Project number:
   6199-2020CIB).
CR Afzaal M, 2022, FRONT MICROBIOL, V13, DOI 10.3389/fmicb.2022.999001
   [Anonymous], 1999, NOM-062-ZOO
   [Anonymous], 2024, Repositorio de Tesis DGBSDI
   [Anonymous], 2014, Health and the Gut
   Arnoriaga-Rodríguez M, 2019, REV ENDOCR METAB DIS, V20, P473, DOI 10.1007/s11154-019-09537-5
   Badji A, 2023, AGEING RES REV, V90, DOI 10.1016/j.arr.2023.102042
   Beck D, 2022, HUM BRAIN MAPP, V43, P700, DOI 10.1002/hbm.25680
   Beurel E, 2024, GUT MICROBES, V16, DOI 10.1080/19490976.2024.2327409
   Birrell JM, 2000, J NEUROSCI, V20, P4320
   Bisgaard H, 2011, J ALLERGY CLIN IMMUN, V128, P646, DOI 10.1016/j.jaci.2011.04.060
   Bissonette GB, 2012, NEUROPHARMACOLOGY, V62, P1168, DOI 10.1016/j.neuropharm.2011.03.011
   Bremner JD, 2020, NUTRIENTS, V12, DOI 10.3390/nu12082428
   Brown VJ, 2016, CURR TOP BEHAV NEURO, V28, P363, DOI 10.1007/7854_2015_5002
   Cai HY, 2022, FOOD NUTR RES, V66, DOI 10.29219/fnr.v66.7974
   Cervenka I, 2017, SCIENCE, V357, DOI 10.1126/science.aaf9794
   Colacicco G, 2002, BEHAV BRAIN RES, V132, P95, DOI 10.1016/S0166-4328(01)00391-6
   Cole JR, 2014, NUCLEIC ACIDS RES, V42, pD633, DOI 10.1093/nar/gkt1244
   Dalley J., 2023, Transl. Psychiatry, V13, P81
   de Noronha SISR, 2024, BIOL RES, V57, DOI 10.1186/s40659-024-00505-1
   Deng YY, 2021, GUT MICROBES, V13, DOI 10.1080/19490976.2020.1869501
   DeSantis TZ, 2006, APPL ENVIRON MICROB, V72, P5069, DOI 10.1128/AEM.03006-05
   Douglas GM, 2020, NAT BIOTECHNOL, V38, P685, DOI 10.1038/s41587-020-0548-6
   Feola B, 2020, NEUROPSYCHOLOGIA, V148, DOI 10.1016/j.neuropsychologia.2020.107636
   Flores-Reséndiz C, 2019, J PEDIATR PSYCHOL, V44, P208, DOI 10.1093/jpepsy/jsy074
   Forte N, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21051554
   Foster JA, 2017, NEUROBIOL STRESS, V7, P124, DOI 10.1016/j.ynstr.2017.03.001
   Fransen F, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.00754
   Fu C, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15020231
   github, PICRUSt2 Tutorial (v2.3.0 Beta)
   Hamamah S, 2023, NUTRIENTS, V15, DOI 10.3390/nu15153365
   Heisler JM, 2015, JOVE-J VIS EXP, DOI 10.3791/51944
   Herculano B, 2013, J ALZHEIMERS DIS, V33, P983, DOI 10.3233/JAD-2012-121324
   Hua YA, 2022, NUTR METAB, V19, DOI 10.1186/s12986-022-00675-3
   Imdad S, 2024, SCI REP-UK, V14, DOI 10.1038/s41598-024-52852-4
   Jin YZ, 2023, LANCET HEALTH LONGEV, V4, pE265, DOI 10.1016/S2666-7568(23)00054-5
   Kanehisa M, 2000, NUCLEIC ACIDS RES, V28, P27, DOI 10.1093/nar/28.1.27
   Karlsson F, 2013, DIABETES, V62, P3341, DOI 10.2337/db13-0844
   Keefe CR, 2023, PLOS COMPUT BIOL, V19, DOI 10.1371/journal.pcbi.1011676
   Kim CS, 2021, J GERONTOL A-BIOL, V76, P32, DOI 10.1093/gerona/glaa090
   Kim GH, 2023, CLIN EXP PEDIATR, V66, P274, DOI 10.3345/cep.2021.01550
   Kim YS, 2020, WORLD J MENS HEALTH, V38, P48, DOI 10.5534/wjmh.190009
   Klindworth A, 2013, NUCLEIC ACIDS RES, V41, DOI 10.1093/nar/gks808
   Kozich JJ, 2013, APPL ENVIRON MICROB, V79, P5112, DOI 10.1128/AEM.01043-13
   Kropp DR, 2024, BRAIN BEHAV IMMUN-HL, V37, DOI 10.1016/j.bbih.2024.100755
   Kumar SA, 2016, BRIT J NUTR, V116, P1502, DOI 10.1017/S0007114516003627
   Lapiz-Bluhm MDS, 2008, J NEUROENDOCRINOL, V20, P1115, DOI 10.1111/j.1365-2826.2008.01772.x
   Lapiz-Bluhm MDS, 2009, PSYCHOPHARMACOLOGY, V202, P329, DOI 10.1007/s00213-008-1224-6
   Lee S, 2018, EXP NEUROBIOL, V27, P277, DOI 10.5607/en.2018.27.4.277
   Leigh SJ, 2020, BBA-MOL BASIS DIS, V1866, DOI 10.1016/j.bbadis.2020.165767
   Liu XN, 2021, CELL METAB, V33, P923, DOI 10.1016/j.cmet.2021.02.002
   Madison A, 2019, CURR OPIN BEHAV SCI, V28, P105, DOI 10.1016/j.cobeha.2019.01.011
   Marano G, 2023, WORLD J GASTROENTERO, V29, P5945, DOI 10.3748/wjg.v29.i45.5945
   May AA, 2016, PHYSIOL BEHAV, V165, P392, DOI 10.1016/j.physbeh.2016.08.025
   McDonald D, 2012, ISME J, V6, P610, DOI 10.1038/ismej.2011.139
   McLean FH, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-30265-4
   mdpi, The Gut Microbiome and Female Health
   Miralbell J, 2013, CEREBROVASC DIS, V36, P98, DOI 10.1159/000352059
   Morys J, 2024, FRONT MOL NEUROSCI, V17, DOI 10.3389/fnmol.2024.1415567
   Murphy EA, 2015, CURR OPIN CLIN NUTR, V18, P515, DOI 10.1097/MCO.0000000000000209
   Newman LA, 2011, DEV PSYCHOBIOL, V53, P391, DOI 10.1002/dev.20537
   Org E, 2016, GUT MICROBES, V7, P313, DOI 10.1080/19490976.2016.1203502
   Oros-Pantoja R, 2014, FASEB J, V28
   Parks DH, 2014, BIOINFORMATICS, V30, P3123, DOI 10.1093/bioinformatics/btu494
   Parks DH, 2010, BIOINFORMATICS, V26, P715, DOI 10.1093/bioinformatics/btq041
   Quast C, 2013, NUCLEIC ACIDS RES, V41, pD590, DOI 10.1093/nar/gks1219
   Queiroz SAL, 2022, FRONT PSYCHIATRY, V13, DOI 10.3389/fpsyt.2022.872594
   Quesada-Vazquez S, 2023, CELL REP MED, V4, DOI 10.1016/j.xcrm.2023.101341
   Ratsika A, 2024, BRAIN BEHAV IMMUN, V121, P317, DOI 10.1016/j.bbi.2024.07.020
   Reichelt AC, 2019, FOOD FUNCT, V10, P1985, DOI [10.1039/C8FO02118J, 10.1039/c8fo02118j]
   Rognes T, 2016, PEERJ, V4, DOI 10.7717/peerj.2584
   Romaní-Pérez M, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22115830
   Ruiz-Vargas J., 2005, Las Claves del Mobbing, P35
   Schloss PD, 2020, APPL ENVIRON MICROB, V86, DOI 10.1128/AEM.02343-19
   Schwarcz R, 2002, J PHARMACOL EXP THER, V303, P1, DOI 10.1124/jpet.102.034439
   Shobeiri P, 2022, BIOL SEX DIFFER, V13, DOI 10.1186/s13293-022-00422-6
   Tait DS, 2018, NEUROSCI BIOBEHAV R, V89, P72, DOI 10.1016/j.neubiorev.2018.02.013
   Van Hul M, 2023, NAT REV ENDOCRINOL, V19, P258, DOI 10.1038/s41574-022-00794-0
   Wallace J, 2014, J PSYCHOPHARMACOL, V28, P691, DOI 10.1177/0269881114531663
   Wang QW, 2023, PROTEIN CELL, V14, P762, DOI 10.1093/procel/pwad026
   Wang YC, 2023, FRONT AGING NEUROSCI, V15, DOI 10.3389/fnagi.2023.1229559
   Warmbrunn MV, 2024, GUT MICROBES, V16, DOI 10.1080/19490976.2024.2370616
   Watson LS, 2020, BEHAV BRAIN RES, V382, DOI 10.1016/j.bbr.2019.112454
   Xu Y, 2022, AMB EXPRESS, V12, DOI 10.1186/s13568-022-01387-w
   Yanguas-Casás N, 2021, NEUROBIOL DIS, V159, DOI 10.1016/j.nbd.2021.105495
   Young JW, 2010, COGN AFFECT BEHAV NE, V10, P243, DOI 10.3758/CABN.10.2.243
   Yu HN, 2021, FOOD FUNCT, V12, P6416, DOI [10.1039/D1FO00044F, 10.1039/d1fo00044f]
   Zhu XY, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms242316733
NR 87
TC 0
Z9 0
U1 7
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-2607
J9 MICROORGANISMS
JI Microorganisms
PD DEC
PY 2024
VL 12
IS 12
AR 2542
DI 10.3390/microorganisms12122542
PG 18
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA Q6H6X
UT WOS:001385669800001
PM 39770745
OA gold
DA 2025-06-11
ER

PT J
AU Jeh, SU
   Yoon, S
   Choi, JH
   Do, J
   Seo, DH
   Lee, SW
   Choi, SM
   Lee, C
   Kam, SC
   Hwa, JS
   Chung, KH
   Kang, HW
   Hyun, JS
AF Jeh, Seong Uk
   Yoon, Sol
   Choi, Jae Hwi
   Do, Jungmo
   Seo, Deok Ha
   Lee, Sin Woo
   Choi, See Min
   Lee, Chunwoo
   Kam, Sung Chul
   Hwa, Jeong Seok
   Chung, Ky Hyun
   Kang, Ho Won
   Hyun, Jae Seog
TI Metabolic Syndrome Is an Independent Risk Factor for Acquired Premature
   Ejaculation
SO WORLD JOURNAL OF MENS HEALTH
LA English
DT Article
DE Metabolic syndrome; Obesity; Premature ejaculation; Risk factors; Sexual
   dysfunctions; Type 2 diabetes
ID AD-HOC COMMITTEE; INTERNATIONAL-SOCIETY; ERECTILE DYSFUNCTION;
   TESTOSTERONE LEVELS; SEXUAL ATTITUDES; NITRIC-OXIDE; PREVALENCE; MEN;
   ASSOCIATIONS; DEFINITION
AB Purpose: To determine the role of metabolic syndrome (MetS) as a risk factor for acquired premature ejaculation (PE) after considering the various risk factors, such as lower urinary tract symptoms, erectile dysfunction, hypogonadism, and prostatitis.
   Materials and Methods: From January 2012 to January 2017, records of 1,029 men were analyzed. We performed multivariate analysis to identify risk factors for PE, including the covariate of age, marital status, International Prostate Symptom Score, International Index of Erectile Function (IIEF) score, National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) score, serum testosterone levels, and all components of MetS. Acquired PE was defined as self-reported intravaginal ejaculation latency time <= 3 minutes, and MetS was diagnosed using the modified National Cholesterol Education Program Adult Treatment Panel III criteria.
   Results: Of 1,029 men, 74 subjects (7.2%) had acquired PE and 111 (10.8%) had MetS. Multivariate analysis showed that the IIEF overall satisfaction score (odds ratio [OR]=0.67, p<0.001), NIH-CPSI pain score (OR=1.07, p=0.035), NIH-CPSI voiding score (OR=1.17, p=0.032), and presence of MetS (OR=2.20, p=0.022) were significantly correlated with the prevalence of acquired PE. In addition, the Male Sexual Health Questionnaire for Ejaculatory Dysfunction scores and ejaculation anxiety scores progressively decreased as the number of components of MetS increased.
   Conclusions: MetS may be an independent predisposing factor for the development of acquired PE. Effective prevention and treatment of MetS could also be important for the prevention and treatment of acquired PE.
C1 [Jeh, Seong Uk; Yoon, Sol; Choi, Jae Hwi; Lee, Sin Woo; Choi, See Min; Hwa, Jeong Seok; Chung, Ky Hyun; Hyun, Jae Seog] Gyeongsang Natl Univ, Gyeongsang Natl Univ Hosp, Dept Urol, Sch Med, 79 Gangnam Ro, Jinju 52727, South Korea.
   [Do, Jungmo; Seo, Deok Ha; Lee, Chunwoo; Kam, Sung Chul] Gyeongsang Natl Univ, Dept Urol, Changwon Hosp, Chang Won, South Korea.
   [Kang, Ho Won] Chungbuk Natl Univ, Dept Urol, Coll Med, Cheongju, South Korea.
C3 Gyeongsang National University; Gyeongsang National University Hospital;
   Gyeongsang National University; Chungbuk National University
RP Hyun, JS (corresponding author), Gyeongsang Natl Univ, Gyeongsang Natl Univ Hosp, Dept Urol, Sch Med, 79 Gangnam Ro, Jinju 52727, South Korea.
EM hyunjs@gnu.ac.kr
RI Kim, Seul Kee/A-6076-2015; Choi, See Min/G-8227-2014
OI Lee, Sin Woo/0000-0002-3050-6366; Choi, See Min/0000-0002-6599-2640;
   Lee, Chunwoo/0000-0002-5846-7039; Jeh, Seong Uk/0000-0003-3808-8768;
   Yoon, Sol/0000-0002-3627-3858; KAM, SUNG CHUL/0000-0001-5403-3623
CR Bolat D, 2017, INT J IMPOT RES, V29, P105, DOI 10.1038/ijir.2017.3
   Corona G, 2013, PREMATURE EJACULATIO, P289
   Corona G, 2008, J SEX MED, V5, P1991, DOI 10.1111/j.1743-6109.2008.00803.x
   El-Nashaar A, 2007, J SEX MED, V4, P491, DOI 10.1111/j.1743-6109.2006.00243.x
   Gonen M, 2005, J ANDROL, V26, P601, DOI 10.2164/jandrol.04159
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Heidler S, 2007, J UROLOGY, V177, P651, DOI 10.1016/j.juro.2006.09.043
   Jern P, 2014, SEX MED-UK, V2, P107, DOI 10.1002/sm2.34
   Laumann EO, 2005, INT J IMPOT RES, V17, P39, DOI 10.1038/sj.ijir.3901250
   Lee SW, 2013, INT J IMPOT RES, V25, P12, DOI 10.1038/ijir.2012.27
   Lee WK, 2013, J SEX MED, V10, P2832, DOI 10.1111/jsm.12287
   McMahon CG, 2012, J SEX MED, V9, P454, DOI 10.1111/j.1743-6109.2011.02507.x
   McMahon CG, 2005, J SEX MED, V2, P368, DOI 10.1111/j.1743-6109.2005.20351.x
   McMahon CG, 2008, J SEX MED, V5, P1590, DOI 10.1111/j.1743-6109.2008.00901.x
   Muldoon MF, 2004, J CLIN ENDOCR METAB, V89, P266, DOI 10.1210/jc.2003-031295
   Nicolosi A, 2004, UROLOGY, V64, P991, DOI 10.1016/j.urology.2004.06.055
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Porst H, 2007, EUR UROL, V51, P816, DOI 10.1016/j.eururo.2006.07.004
   Rosmond R, 2002, ANN NY ACAD SCI, V967, P571
   Serefoglu EC, 2014, J SEX MED, V11, P1423, DOI 10.1111/jsm.12524
   Shoelson SE, 2007, GASTROENTEROLOGY, V132, P2169, DOI 10.1053/j.gastro.2007.03.059
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Sullivan ME, 1999, CARDIOVASC RES, V43, P658, DOI 10.1016/S0008-6363(99)00135-2
   Takeuchi T, 2009, DIABETES METAB, V35, P32, DOI 10.1016/j.diabet.2008.06.006
   Vallance P, 2001, HEART, V85, P342, DOI 10.1136/heart.85.3.342
   Waldinger MD, 1998, BEHAV BRAIN RES, V92, P111, DOI 10.1016/S0166-4328(97)00183-6
   Wein AJ, 2009, BJU INT, V103, P33, DOI 10.1111/j.1464-410X.2009.08447.x
   Wheatcroft SB, 2003, DIABETIC MED, V20, P255, DOI 10.1046/j.1464-5491.2003.00869.x
   WHO, 2000, AIR QUALITY GUIDELIN, VSecond Edition, P11
NR 29
TC 17
Z9 18
U1 0
U2 3
PU KOREAN SOC SEXUAL MEDICINE & ANDROLOGY
PI GWANGJU
PA DEPT UROLOGY, CHONNAM NATL UNIV MEDICAL SCH, 671 JEBONG-RO, DONG-GU,
   GWANGJU, 501-757, SOUTH KOREA
SN 2287-4208
EI 2287-4690
J9 WORLD J MENS HEALTH
JI World J. Mens Health
PD MAY
PY 2019
VL 37
IS 2
BP 226
EP 233
DI 10.5534/wjmh.180062
PG 8
WC Andrology; Health Care Sciences & Services; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Health Care Sciences & Services; Urology &
   Nephrology
GA HU7PV
UT WOS:000465475300012
PM 30588783
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Motta, AB
AF Motta, A. B.
TI Mechanisms Involved in Metformin Action in the Treatment of Polycystic
   Ovary Syndrome
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Polycystic ovary syndrome (PCOS); metformin; diabetes; adolescents;
   pregnancy; ovulation; cardiovascular
ID ACTIVATED PROTEIN-KINASE; MIGRATION INHIBITORY FACTOR; FACTOR-KAPPA-B;
   INNATE IMMUNE-RESPONSES; NECROSIS-FACTOR-ALPHA; FACTOR MIF; INSULIN
   SENSITIVITY; MONONUCLEAR-CELLS; OXIDATIVE STRESS; MESSENGER-RNA
AB The N, N' dimethyl-biguanide : Metformin is an antidiabetic drug that increases glucose utilization in insulin-sensitive tissues. As Polycystic Ovary Syndrome ( PCOS) and diabetes share some altered parameters-such as abnormal glucose: insulin ratio, altered lipidic metabolism and insulin-resistance syndrome-the use of metformin has become increasingly accepted and widespread in the treatment of PCOS. Currently, metformin is used to induce ovulation and during early pregnancy in PCOS patients, however, a complete knowledge of the metformin action has not been achieved yet. This review describes beyond the classical reproductive action of metformin and explores other benefits of the drug. In addition, the present work discusses the molecular mechanisms involved further than the classical pathway that involves the AMP-activated protein kinase.
C1 Univ Buenos Aires, Fac Med, Lab Fisiopatol, CEFYBO, RA-1121 Buenos Aires, DF, Argentina.
C3 University of Buenos Aires
RP Motta, AB (corresponding author), Univ Buenos Aires, Fac Med, Lab Fisiopatol, CEFYBO, Paraguay 2155, RA-1121 Buenos Aires, DF, Argentina.
EM aliciabmotta@yahoo.com
FU Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT) [PICT
   949]
FX The author wants to thank the support obtained from Agencia Nacional de
   Promocion Cientifica y Tecnologica (ANPCyT), PICT 949.
CR Abbott DH, 2002, J ENDOCRINOL, V174, DOI 10.1677/joe.0.1740001
   Alimova IN, 2009, CELL CYCLE, V8, P909, DOI 10.4161/cc.8.6.7933
   Aljada A, 2006, METABOLISM, V55, P1177, DOI 10.1016/j.metabol.2006.04.016
   Asunción M, 2000, J CLIN ENDOCR METAB, V85, P2434, DOI 10.1210/jc.85.7.2434
   Motta DAB, 2008, CURR PHARM DESIGN, V14, P2121
   Birdsall MA, 1997, ANN INTERN MED, V126, P32, DOI 10.7326/0003-4819-126-1-199701010-00005
   Bonnefont-Rousselot D, 2003, METABOLISM, V52, P586, DOI 10.1053/meta.2003.50093
   Ceriello A, 2000, METABOLISM, V49, P27, DOI 10.1016/S0026-0495(00)80082-7
   Chu NV, 2002, DIABETES CARE, V25, P542, DOI 10.2337/diacare.25.3.542
   DAHLGREN E, 1992, ACTA OBSTET GYN SCAN, V71, P599, DOI 10.3109/00016349209006227
   Dandona P, 2004, J CLIN ENDOCR METAB, V89, P5043, DOI 10.1210/jc.2004-0436
   Diamanti-Kandarakis E, 2005, EUR J ENDOCRINOL, V152, P749, DOI 10.1530/eje.1.01910
   El-Mir MY, 2000, J BIOL CHEM, V275, P223, DOI 10.1074/jbc.275.1.223
   Elia E, 2006, MOL HUM REPROD, V12, P475, DOI 10.1093/molehr/gal057
   ELIA EM, 2009, MOL HUM REP IN PRESS
   EWIS SA, 1995, J APPL TOXICOL, V15, P387, DOI 10.1002/jat.2550150508
   Faure P, 1999, DIABETES, V48, P353, DOI 10.2337/diabetes.48.2.353
   Ferri C, 1998, DIABETES, V47, P660, DOI 10.2337/diabetes.47.4.660
   FRANKS S, 1995, NEW ENGL J MED, V333, P853, DOI 10.1056/NEJM199509283331307
   Frederich M, 2002, J BIOL CHEM, V277, P1928, DOI 10.1074/jbc.M107128200
   Froidevaux C, 2001, CRIT CARE MED, V29, pS13, DOI 10.1097/00003246-200107001-00006
   Froment P, 2006, PPAR RES, V2006, DOI 10.1155/PPAR/2006/73986
   Fryer LGD, 2002, J BIOL CHEM, V277, P25226, DOI 10.1074/jbc.M202489200
   Glueck CJ, 2001, METABOLISM, V50, P856, DOI 10.1053/meta.2001.24192
   Gonzalez F, 1999, METABOLISM, V48, P437, DOI 10.1016/S0026-0495(99)90100-2
   González F, 2006, J CLIN ENDOCR METAB, V91, P1508, DOI 10.1210/jc.2005-2327
   Hawley SA, 2002, DIABETES, V51, P2420, DOI 10.2337/diabetes.51.8.2420
   Heutling D, 2008, J CLIN ENDOCR METAB, V93, P82, DOI 10.1210/jc.2007-0842
   Isoda K, 2006, ARTERIOSCL THROM VAS, V26, P611, DOI 10.1161/01.ATV.0000201938.78044.75
   Jakubowicz DJ, 2001, J CLIN ENDOCR METAB, V86, P1126, DOI 10.1210/jc.86.3.1126
   Karastergiou K, 2008, CURR PHARM DESIGN, V14, P2527, DOI 10.2174/138161208786071272
   Khouri H, 2004, EUR J BIOCHEM, V271, P4745, DOI 10.1111/j.1432-1033.2004.04438.x
   Legro RS, 2008, J CLIN ENDOCR METAB, V93, P792, DOI 10.1210/jc.2007-1736
   McCredie RJ, 1998, J AM COLL CARDIOL, V32, P1331, DOI 10.1016/S0735-1097(98)00416-1
   Minokoshi Y, 2002, NATURE, V415, P339, DOI 10.1038/415339a
   Mitchell RA, 2002, P NATL ACAD SCI USA, V99, P345, DOI 10.1073/pnas.012511599
   Moghetti P, 2000, J CLIN ENDOCR METAB, V85, P139, DOI 10.1210/jc.85.1.139
   Mohanty P, 2000, J CLIN ENDOCR METAB, V85, P2970, DOI 10.1210/jc.85.8.2970
   Mohanty P, 2004, J CLIN ENDOCR METAB, V89, P2728, DOI 10.1210/jc.2003-032103
   Mongiovì M, 2008, CURR PHARM DESIGN, V14, P736, DOI 10.2174/138161208784007725
   Musi N, 2002, DIABETES, V51, P2074, DOI 10.2337/diabetes.51.7.2074
   Owen MR, 2000, BIOCHEM J, V348, P607, DOI 10.1042/0264-6021:3480607
   Palomba S, 2006, HUM REPROD, V21, P457, DOI 10.1093/humrep/dei351
   Pavlovic D, 2000, DIABETES OBES METAB, V2, P251, DOI 10.1046/j.1463-1326.2000.00089.x
   Pierpoint T, 1998, J CLIN EPIDEMIOL, V51, P581, DOI 10.1016/S0895-4356(98)00035-3
   PREVELIC GM, 1995, CLIN ENDOCRINOL OXF, V43, P677
   Reaven GM, 1996, CIRCULATION, V93, P1780, DOI 10.1161/01.CIR.93.10.1780
   Roger T, 2001, J ENDOTOXIN RES, V7, P456, DOI 10.1177/09680519010070061101
   Rösen P, 2001, DIABETES-METAB RES, V17, P189, DOI 10.1002/dmrr.196
   Ruggiero-Lopez D, 1999, BIOCHEM PHARMACOL, V58, P1765, DOI 10.1016/S0006-2952(99)00263-4
   Sander V, 2006, REPRODUCTION, V131, P591, DOI 10.1530/rep.1.00941
   Solano ME, 2008, CLIN EXP IMMUNOL, V153, P289, DOI 10.1111/j.1365-2249.2008.03696.x
   Solano ME, 2006, REPROD FERT DEVELOP, V18, P533, DOI 10.1071/RD05099
   Srividhya S, 2002, J Biochem Mol Biol Biophys, V6, P379, DOI 10.1080/1025814021000024280
   Tanaka Y, 1999, EUR J PHARMACOL, V376, P17, DOI 10.1016/S0014-2999(99)00342-8
   Tessier D, 1999, METABOLISM, V48, P897, DOI 10.1016/S0026-0495(99)90226-3
   Trivin F, 1999, ANN BIOL CLIN-PARIS, V57, P445
   Woods A, 2003, CURR BIOL, V13, P2004, DOI 10.1016/j.cub.2003.10.031
   Yang TL, 2005, N-S ARCH PHARMACOL, V371, P401, DOI 10.1007/s00210-005-1060-8
   Youssef S, 1999, KIDNEY INT, V55, P907, DOI 10.1046/j.1523-1755.1999.055003907.x
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI13505
   Zou MH, 2004, J BIOL CHEM, V279, P43940, DOI 10.1074/jbc.M404421200
NR 62
TC 7
Z9 8
U1 0
U2 7
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD SEP
PY 2009
VL 15
IS 26
BP 3074
EP 3077
DI 10.2174/138161209789058101
PG 4
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 485TZ
UT WOS:000269149000008
PM 19754381
OA Green Published
DA 2025-06-11
ER

PT J
AU Lupachyk, S
   Watcho, P
   Obrosov, AA
   Stavniichuk, R
   Obrosova, IG
AF Lupachyk, Sergey
   Watcho, Pierre
   Obrosov, Alexander A.
   Stavniichuk, Roman
   Obrosova, Irma G.
TI Endoplasmic reticulum stress contributes to prediabetic peripheral
   neuropathy
SO EXPERIMENTAL NEUROLOGY
LA English
DT Article
DE Diabetic peripheral neuropathy; Endoplasmic reticulum stress; Eukaryotic
   initiation factor-2 alpha; High-fat diet fed mouse; Motor nerve
   conduction velocity; Prediabetic peripheral neuropathy; Salubrinal;
   Sensory nerve conduction velocity; Streptozotocin; Trimethylamine oxide;
   Unfolded protein response; Zucker (fa/fa) rat
ID ALDOSE REDUCTASE INHIBITION; IMPAIRED GLUCOSE-TOLERANCE; ZUCKER DIABETIC
   FATTY; NERVE-FIBER DENSITY; OXIDATIVE-STRESS; METABOLIC SYNDROME; MOUSE
   MODEL; CHRONIC COMPLICATIONS; ANTIOXIDANT DEFENSE; INSULIN SENSITIVITY
AB Growing evidence suggests that prediabetes and metabolic syndrome are associated with increased risk for the development of microvascular complications including retinopathy, nephropathy, and, most commonly, peripheral painful neuropathy and/or autonomic neuropathy. The etiology of these disabling neuropathies is unclear, and several clinical and experimental studies implicated obesity, impaired fasting glycemia/impaired glucose tolerance, elevated triglyceride and non-esterified fatty acids, as well as oxidative-nitrative stress. Endoplasmic reticulum stress resulting from abnormal folding of newly synthesized proteins and leading to the impairment of metabolism, transcriptional regulation, and gene expression, is emerging as a key mechanism of metabolic diseases including obesity and diabetes. We evaluated the role for this phenomenon in prediabetic neuropathy using two animal models i.e., Zucker (fa/fa) rats and high-fat diet fed mice which displayed obesity and impaired glucose tolerance in the absence of overt hyperglycemia. Endoplasmic reticulum stress manifest in upregulation of the glucose-regulated proteins BiP/GRP78 and GRP94 of unfolded protein response was identified in the sciatic nerve of Zucker rats. A chemical chaperone, trimethylamine oxide, blunted endoplasmic reticulum stress and alleviated sensory nerve conduction velocity deficit, thermal and mechanical hypoalgesia, and tactile allodynia. A selective inhibitor of eukaiyotic initiation factor-2 alpha dephosphorylation, salubrinal, improved glucose intolerance and alleviated peripheral nerve dysfunction in high-fat diet fed mice. Our findings suggest an important role of endoplasmic reticulum stress in the neurobiology of prediabetic peripheral neuropathy, and identify a new therapeutic target. (c) 2013 Elsevier Inc. All rights reserved.
C1 [Lupachyk, Sergey; Watcho, Pierre; Obrosov, Alexander A.; Stavniichuk, Roman; Obrosova, Irma G.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center
RP Obrosova, IG (corresponding author), Louisiana State Univ Syst, Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM obrosoig@pbrc.edu
FU National Institutes of Health [RO1DK074517, RO1DK077141, RO1DK081147]
FX S.L., P.W., A.A.O., R.S., and I.G.O. were partially supported by the
   National Institutes of Health grants RO1DK074517, RO1DK077141, and
   RO1DK081147 (all to I.G.O.).
CR Bonadonna RC, 2006, DIABETES CARE, V29, P2701, DOI 10.2337/dc06-0942
   Boulton AJM, 2005, DIABETES CARE, V28, P956, DOI 10.2337/diacare.28.4.956
   Boyce M, 2005, SCIENCE, V307, P935, DOI 10.1126/science.1101902
   Cnop M, 2007, J BIOL CHEM, V282, P3989, DOI 10.1074/jbc.M607627200
   Coppey L, 2011, NEUROPHARMACOLOGY, V60, P259, DOI 10.1016/j.neuropharm.2010.09.008
   Costa LA, 2004, DIABETIC MED, V21, P252, DOI 10.1111/j.1464-5491.2004.01124.x
   Drel VR, 2007, INT J MOL MED, V20, P783
   Drel VR, 2010, ENDOCRINOLOGY, V151, P2547, DOI 10.1210/en.2009-1342
   Dyck PJ, 2007, MUSCLE NERVE, V36, P536, DOI 10.1002/mus.20846
   Eizirik DL, 2008, ENDOCR REV, V29, P42, DOI 10.1210/er.2007-0015
   Fu SN, 2012, CELL METAB, V15, P623, DOI 10.1016/j.cmet.2012.03.007
   Fu SN, 2011, NATURE, V473, P528, DOI 10.1038/nature09968
   Henriksen EJ, 2011, FREE RADICAL BIO MED, V51, P993, DOI 10.1016/j.freeradbiomed.2010.12.005
   Hoehn KL, 2009, P NATL ACAD SCI USA, V106, P17787, DOI 10.1073/pnas.0902380106
   Hotamisligil GS, 2010, NAT MED, V16, P396, DOI 10.1038/nm0410-396
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   Hummasti S, 2010, CIRC RES, V107, P579, DOI 10.1161/CIRCRESAHA.110.225698
   Isomaa B, 2001, DIABETOLOGIA, V44, P1148, DOI 10.1007/s001250100615
   Kars M, 2010, DIABETES, V59, P1899, DOI 10.2337/db10-0308
   Kato N, 2000, DIABETES RES CLIN PR, V50, P77, DOI 10.1016/S0168-8227(00)00164-9
   Kaufman RJ, 2010, DIABETES OBES METAB, V12, P99, DOI 10.1111/j.1463-1326.2010.01281.x
   Kharroubi I, 2004, ENDOCRINOLOGY, V145, P5087, DOI 10.1210/en.2004-0478
   Lauria G, 2005, J PERIPHER NERV SYST, V10, P202, DOI 10.1111/j.1085-9489.2005.0010210.x
   Longo KA, 2011, J PHARMACOL EXP THER, V339, P115, DOI 10.1124/jpet.111.183764
   Lupachyk S, 2012, FREE RADICAL BIO MED, V52, P1255, DOI 10.1016/j.freeradbiomed.2012.01.029
   Maris M, 2012, DIABETOLOGIA, V55, P1167, DOI 10.1007/s00125-011-2427-7
   Muellenbach EA, 2008, METABOLISM, V57, P1465, DOI 10.1016/j.metabol.2008.05.018
   Obrosova IG, 2004, DIABETES, V53, P711, DOI 10.2337/diabetes.53.3.711
   Obrosova IG, 2008, FREE RADICAL BIO MED, V44, P972, DOI 10.1016/j.freeradbiomed.2007.09.013
   Obrosova IG, 2007, DIABETES, V56, P2598, DOI 10.2337/db06-1176
   Oltman CL, 2008, OBESITY, V16, P82, DOI 10.1038/oby.2007.19
   Oltman CL, 2005, AM J PHYSIOL-ENDOC M, V289, pE113, DOI 10.1152/ajpendo.00594.2004
   Pallet N, 2008, AM J TRANSPLANT, V8, P2283, DOI 10.1111/j.1600-6143.2008.02396.x
   Pittenger GL, 2005, METAB SYNDR RELAT D, V3, P113, DOI 10.1089/met.2005.3.113
   Saxena S, 2009, NAT NEUROSCI, V12, P627, DOI 10.1038/nn.2297
   Shertzer HG, 2008, BIOCHEM PHARMACOL, V75, P1402, DOI 10.1016/j.bcp.2007.12.003
   Shevalye H, 2012, DIABETES, V61, P2126, DOI 10.2337/db11-1524
   Shevalye H, 2012, ENDOCRINOLOGY, V153, P1152, DOI 10.1210/en.2011-1997
   Sims-Robinson C, 2012, DIABETOLOGIA, V55, P2276, DOI 10.1007/s00125-012-2573-6
   Sinnreich M, 2005, NEUROLOGIST, V11, P63, DOI 10.1097/01.nrl.0000156314.24508.ed
   Smith AG, 2008, J NEUROL SCI, V273, P25, DOI 10.1016/j.jns.2008.06.005
   Smith AG, 2006, DIABETES CARE, V29, P1294, DOI 10.2337/dc06-0224
   Smith AG, 2001, NEUROLOGY, V57, P1701, DOI 10.1212/WNL.57.9.1701
   Sokka AL, 2007, J NEUROSCI, V27, P901, DOI 10.1523/JNEUROSCI.4289-06.2007
   Sparks LM, 2005, DIABETES, V54, P1926, DOI 10.2337/diabetes.54.7.1926
   Stavniichuk R, 2010, FREE RADICAL BIO MED, V49, P1036, DOI 10.1016/j.freeradbiomed.2010.06.016
   Sumner CJ, 2003, NEUROLOGY, V60, P108, DOI 10.1212/WNL.60.1.108
   Tesfaye S, 2005, NEW ENGL J MED, V352, P341, DOI 10.1056/NEJMoa032782
   Tesfaye S, 2010, DIABETES CARE, V33, P2285, DOI 10.2337/dc10-1303
   Tong XY, 2010, CIRC RES, V107, P975, DOI 10.1161/CIRCRESAHA.110.221242
   Veves A, 2008, PAIN MED, V9, P660, DOI 10.1111/j.1526-4637.2007.00347.x
   Vincent AM, 2009, DIABETES, V58, P2376, DOI 10.2337/db09-0047
   Watcho P, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/268547
   Wei P, 2004, DIABETOLOGIA, V47, P1541, DOI 10.1007/s00125-004-1489-1
   Weisberg SP, 2008, ENDOCRINOLOGY, V149, P3549, DOI 10.1210/en.2008-0262
   Wiggin TD, 2009, DIABETES, V58, P1634, DOI 10.2337/db08-1771
   Wu CT, 2011, FREE RADICAL BIO MED, V51, P671, DOI 10.1016/j.freeradbiomed.2011.04.038
   Wu J, 2010, AM J PATHOL, V176, P2163, DOI 10.2353/ajpath.2010.090386
   YAGIHASHI S, 1982, HORM METAB RES, V14, P10, DOI 10.1055/s-2007-1018908
   ZAWALICH WS, 1995, BIOCHEM BIOPH RES CO, V209, P974, DOI 10.1006/bbrc.1995.1593
   Zhong YM, 2012, DIABETES, V61, P492, DOI 10.2337/db11-0315
   Zhou YT, 1998, P NATL ACAD SCI USA, V95, P8898, DOI 10.1073/pnas.95.15.8898
   Zhu Y, 2008, J NEUROSCI, V28, P2168, DOI 10.1523/JNEUROSCI.5232-07.2008
   Ziegler D, 2004, DIABETES CARE, V27, P2178, DOI 10.2337/diacare.27.9.2178
   Ziegler D, 2009, PAIN MED, V10, P393, DOI 10.1111/j.1526-4637.2008.00555.x
NR 65
TC 60
Z9 70
U1 0
U2 27
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0014-4886
J9 EXP NEUROL
JI Exp. Neurol.
PD SEP
PY 2013
VL 247
BP 342
EP 348
DI 10.1016/j.expneurol.2012.11.001
PG 7
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 204VO
UT WOS:000323399600043
PM 23142188
DA 2025-06-11
ER

PT J
AU Alarcón, YB
   González, FB
   Beiza, IRC
   González, ED
   Ramos, JAC
   Arciniega, ADB
   Ramos, RV
   Piña, AES
AF Becerril Alarcon, Yizel
   Bastida Gonzalez, Fernando
   Camacho Beiza, Isidro Roberto
   Davila Gonzalez, Eduardo
   Cruz Ramos, Jose Alfonso
   Benitez Arciniega, Alejandra Donaji
   Valdes Ramos, Roxana
   Soto Pina, Alexandra Estela
TI Association of GSTT1, GSTM1 and GSTP1 (Ile105Val)
   mRNA Expression with Cardiometabolic Risk Parameters in Women with
   Breast Cancer and Comorbidities
SO CARDIOGENETICS
LA English
DT Article
DE Glutathione S-transferase genotypes; cardiometabolic risk; breast
   cancer; comorbidities
ID GLUTATHIONE-S-TRANSFERASE; GENETIC POLYMORPHISMS; P1 POLYMORPHISMS;
   SUSCEPTIBILITY; POPULATION; DISEASE; ENZYMES; MARKERS
AB Breast cancer (BC) and cardiometabolic diseases share a multifactorial and modifiable etiology, modulated by complex molecular pathways. Glutathione S-transferase (GST) plays a critical role, providing protection against xenobiotics and regulating levels of enzymes and proteins in the cell. GST variants have a significant impact on susceptibility to diseases whose pathogenesis involves oxidative stress, as is the case in many inflammatory diseases such as BC and cardiometabolic pathologies. However, the expression of these polymorphic variants has not been studied in BC. This study aimed to evaluate the presence of GST mRNA isoforms and their association with clinical and cardiometabolic parameters in women with BC. This was a case-control study, and a total of 57 participants were recruited. Concentrations of glucose and lipids in blood were measured in all the participants. GST variants (GSTT1, GSTM1 and GSTP1 Ile105Val polymorphism) were evaluated in all the participants by real-time PCR analysis. There was a significant association (p < 0.05) between the frequency of GSTP1 and LDL-c in the BC group. However, the control group showed significant associations between blood pressure with GSTT1 and GSTP1 variants with total cholesterol (TC), LDL-c, VLDL-c and triacylglycerols (TG). Therefore, GSTT1 and GSTP1 variants could be emerging biomarkers to discriminate between BC cases related or not to cardiometabolic disease factors.
C1 [Becerril Alarcon, Yizel; Benitez Arciniega, Alejandra Donaji; Valdes Ramos, Roxana; Soto Pina, Alexandra Estela] Univ Autonoma Estado Mexico, Fac Med, Toluca 50120, Mexico.
   [Bastida Gonzalez, Fernando; Davila Gonzalez, Eduardo] Lab Estatal Salud Publ Estado Mexico, Lab Biol Mol, Toluca 50130, Mexico.
   [Camacho Beiza, Isidro Roberto] Inst Salud Estado Mexico, Unidad Especializada Med Detecc Canc Mama, Toluca 50180, Mexico.
   [Cruz Ramos, Jose Alfonso] Inst Jalisciense Cancerol, Guadalajara 44280, Jalisco, Mexico.
RP Piña, AES (corresponding author), Univ Autonoma Estado Mexico, Fac Med, Toluca 50120, Mexico.
EM ybecerrila048@alumno.uaemex.mx; mijomeil@hotmail.com;
   camacho_beiza@hotmail.com; lalodevl@gmail.com; josealfonsocr@gmail.com;
   abeniteza@uaemex.mx; rvaldesr@uaemex.mx; aesotop@uaemex.mx
RI valdes-ramos, roxana/B-2184-2016; Soto, Alexandra/AAH-4797-2021;
   Cruz-Ramos, Jose Alfonso/T-1387-2018
OI Cruz-Ramos, Jose Alfonso/0000-0002-5791-612X; Valdes-Ramos,
   Roxana/0000-0003-0093-886X; BECERRIL ALARCON, YIZEL/0000-0001-6219-7361
FU Autonomous Mexico State University [4755/2019/CI]
FX This study was supported by Autonomous Mexico State University (Project
   number 4755/2019/CI).
CR Afrand M, 2015, IRAN J PUBLIC HEALTH, V44, P673
   AL-Eitan LN, 2019, ONCOTARGETS THER, V12, P7757, DOI 10.2147/OTT.S207255
   Alriyahee F.A.A., 2019, INT J PHARM QUAL ASS, V10, P242, DOI [10.25258/ijpqa.10.2.5, DOI 10.25258/IJPQA.10.2.5]
   Antonini-Canterin F, 2019, MONALDI ARCH CHEST D, V89, DOI 10.4081/monaldi.2019.1007
   Arand M, 1996, ANAL BIOCHEM, V236, P184, DOI 10.1006/abio.1996.0153
   Bengtsson ÅK, 2004, BLOOD, V104, P1404, DOI 10.1182/blood-2003-10-3380
   BOARD PG, 1989, ANN HUM GENET, V53, P205, DOI 10.1111/j.1469-1809.1989.tb01786.x
   Buono G, 2020, BREAST CANCER RES TR, V182, P401, DOI 10.1007/s10549-020-05701-7
   Campos CZ, 2018, CLIN EXP MED, V18, P27, DOI 10.1007/s10238-017-0461-6
   Canto P, 2008, HYPERTENS RES, V31, P1015, DOI 10.1291/hypres.31.1015
   Cardoso-Peña E, 2020, INT J ENDOCRINOL, V2020, DOI 10.1155/2020/8874916
   Chatterjee A, 2018, CANCER LETT, V433, P33, DOI 10.1016/j.canlet.2018.06.028
   Chielle EO, 2017, EXP CLIN ENDOCR DIAB, V125, P335, DOI 10.1055/s-0042-105279
   Costa-Urrutia P, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph182312659
   Cuevas S, 2019, PHARMACOGENOMICS J, V19, P315, DOI 10.1038/s41397-019-0082-4
   Direccion General de Epidemiologia, 2021, PAN EP ENF TRANSM ME
   Figueiras-Graillet L.M., 2020, CARDIOVASC METAB SCI, V31, P76, DOI [10.35366/95587, DOI 10.35366/95587]
   Flores-Reséndiz C, 2019, J PEDIATR PSYCHOL, V44, P208, DOI 10.1093/jpepsy/jsy074
   Garcia-Estevez L, 2019, BREAST CANCER RES, V21, DOI 10.1186/s13058-019-1124-1
   Ge BH, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0118897
   Ghosn B, 2020, NUTR J, V19, DOI 10.1186/s12937-020-0520-9
   Han JH, 2015, NUTR RES PRACT, V9, P49, DOI 10.4162/nrp.2015.9.1.49
   Huerta-Chagoya A, 2020, GENES-BASEL, V11, DOI 10.3390/genes11010114
   Hussain T, 2018, J GENET, V97, P523, DOI 10.1007/s12041-018-0946-4
   Hwang J, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-62200-x
   Jaramillo-Rangel G, 2015, GENET MOL RES, V14, P6465, DOI 10.4238/2015.June.11.22
   Kimi L, 2016, BIOCHEM GENET, V54, P41, DOI 10.1007/s10528-015-9698-5
   Knight TR, 2007, TOXICOL SCI, V100, P513, DOI 10.1093/toxsci/kfm233
   Koene RJ, 2016, CIRCULATION, V133, P1104, DOI 10.1161/CIRCULATIONAHA.115.020406
   Ma J, 2017, ONCOTARGET, V8, P72939, DOI 10.18632/oncotarget.18513
   Madu CO, 2020, J CANCER, V11, P4474, DOI 10.7150/jca.44313
   Oniki K, 2008, PHARMACOGENET GENOM, V18, P275, DOI 10.1097/FPC.0b013e3282f56176
   Pahwa S, 2017, J CLIN DIAGN RES, V11, pBC5, DOI 10.7860/JCDR/2017/23846.9281
   Patnaik JL, 2011, BREAST CANCER RES, V13, DOI 10.1186/bcr2901
   PEMBLE S, 1994, BIOCHEM J, V300, P271, DOI 10.1042/bj3000271
   Pérez-Morales R, 2008, HUM BIOL, V80, P457, DOI 10.3378/1534-6617-80.4.457
   Possuelo LG, 2013, REV BRAS GINECOL OBS, V35, P569, DOI 10.1590/S0100-72032013001200007
   Rajagopal T, 2021, BREAST CANCER RES TR, V186, P823, DOI 10.1007/s10549-020-06028-z
   Rodriguez CJ, 2014, AM J MED, V127, P1186, DOI 10.1016/j.amjmed.2014.07.026
   Rong SL, 2019, J HUM HYPERTENS, V33, P454, DOI 10.1038/s41371-018-0133-3
   Salimi S, 2015, IRAN J PUBLIC HEALTH, V44, P814
   Segovia-Mendoza M, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.00348
   Shamah-Levy Teresa, 2020, Salud pública Méx, V62, P614
   Singh RR, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10050701
   Song ZW, 2016, THER CLIN RISK MANAG, V12, P763, DOI 10.2147/TCRM.S104339
   Soto-Quintana O., 2011, J CANC THER, V2, P354, DOI [10.4236/jct.2011.23048, DOI 10.4236/JCT.2011.23048]
   Turck N, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043830
   Unger LW, 2019, WIEN KLIN WOCHENSCHR, V131, P395, DOI 10.1007/s00508-019-01544-5
   Upadhyay RK, 2015, J LIPIDS, V2015, DOI 10.1155/2015/971453
   Wang GY, 2006, BIOCHEM BIOPH RES CO, V341, P310, DOI 10.1016/j.bbrc.2005.12.195
   Yuan YV, 2003, J NUTR, V133, P679, DOI 10.1093/jn/133.3.679
   Zhang J, 2018, J BIOL CHEM, V293, P4366, DOI 10.1074/jbc.M117.814327
   Zhu Qiu-Li, 2010, Cancers (Basel), V2, P721, DOI 10.3390/cancers2020721
NR 53
TC 0
Z9 0
U1 2
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2035-8253
EI 2035-8148
J9 CARDIOGENETICS
JI Cardiogenetics
PD SEP
PY 2022
VL 12
IS 3
BP 235
EP 245
DI 10.3390/cardiogenetics12030022
PG 11
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA 4T7YU
UT WOS:000858328300001
OA gold
DA 2025-06-11
ER

PT J
AU Pingali, U
   Nutalapati, C
   Gundagani, S
AF Pingali, Usharani
   Nutalapati, Chandrasekhar
   Gundagani, Srinivas
TI Effect of Omega-3 Fatty Acid Alone and in Combination with Proprietary
   Chromium Complex on Endothelial Function in Subjects with Metabolic
   Syndrome: A Randomized, Double-Blind, Parallel-Group Clinical Study
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID PERIPHERAL ARTERIAL-DISEASE; TYPE-2 DIABETES-MELLITUS; OXIDATIVE STRESS;
   FISH-OIL; PHYLLANTHUS-EMBLICA; INSULIN-RESISTANCE; LIPID PROFILE;
   NITRIC-OXIDE; INFLAMMATION; SUPPLEMENTATION
AB Metabolic syndrome (MetS) represents a cluster of metabolic abnormalities that include hypertension, central obesity, insulin resistance, and dyslipidemia and is strongly associated with an increased risk of diabetes, cardiovascular diseases (CVD), and all-cause mortality. Early diagnosis is important to employ lifestyle and risk factor modification. Existing therapies are limited. Studies report positive effect of omega-3 fatty acids (omega-3FA) on symptoms of metabolic syndrome. The present study was undertaken to evaluate the effect of omega-3FA alone and in combination with proprietary chromium complex (PCC) on endothelial function in subjects with metabolic syndrome. In this randomized, double-blind, parallel-group study, subjects were enrolled into the study after ethics committee (EC) approval and informed consent. Eligible subjects were randomized to receive omega-3FA concentrate 2000 mg (Group A-18 subjects), omega-3FA concentrate 2000 mg + PCC200 mcg (Group B-19 subjects), and omega-3FA concentrate 2000 mg + PCC400 mcg (Group C-21 subjects) daily for 12 weeks. Endothelial dysfunction as measured by reflection index (RI), biomarkers of oxidative stress (NO, MDA, and glutathione), and inflammation (hsCRP, endothelin-1, ICAM-1, and VCAM-1) were evaluated at baseline, 4, and 12 weeks. Lipid-profile and platelet-aggregation tests were performed at baseline and 12 weeks. Adverse drug reactions were recorded. Compliance was assessed by pill count method. GraphPad Prism8 was used for statistical analysis. Significant changes were seen from 4 weeks onwards in all the parameters evaluated. Significant improvement in RI% (mean +/- SD = -2.56 +/- 0.77 to -3.27 +/- 0.67-group A, -2.33 +/- 0.76 to 4.72 +/- 0.79-group B; -2.39 +/- 1.13 to 6.46 +/- 1.00-group C) was seen at 12 weeks. Significant improvement in biomarkers of oxidative stress and inflammation was seen with all the treatment groups. Similarly, significant improvement in lipid profile was seen in group B and group C, while group A showed change in HDL, VLDL, and TG. Group C demonstrated the best response in the parameters evaluated. Three patients in group C reported gastrointestinal adverse events, which resolved spontaneously; none stopped the therapy. So, the addition of PCC to omega-3FA may prove to have beneficial effect in reducing cardiovascular morbidity in MetS patients.
C1 [Pingali, Usharani; Nutalapati, Chandrasekhar; Gundagani, Srinivas] Nizams Inst Med Sci, Dept Clin Pharmacol & Therapeut, Hyderabad 500082, Telangana, India.
C3 Nizam's Institute of Medical Sciences
RP Pingali, U (corresponding author), Nizams Inst Med Sci, Dept Clin Pharmacol & Therapeut, Hyderabad 500082, Telangana, India.
EM ushapingali@yahoo.com
OI Pingali, Usharani/0000-0002-9300-8022
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   An WS, 2009, AM J PHYSIOL-RENAL, V297, pF895, DOI 10.1152/ajprenal.00217.2009
   Aouacheri O, 2015, CAN J DIABETES, V39, P44, DOI 10.1016/j.jcjd.2014.03.002
   Asemi Z, 2016, INT UROL NEPHROL, V48, P1887, DOI 10.1007/s11255-016-1399-4
   Barbato JE, 2005, AM J PHYSIOL-HEART C, V289, pH228, DOI 10.1152/ajpheart.00982.2004
   Calder PC, 2013, BRIT J CLIN PHARMACO, V75, P645, DOI 10.1111/j.1365-2125.2012.04374.x
   Chowienczyk PJ, 1999, J AM COLL CARDIOL, V34, P2007, DOI 10.1016/S0735-1097(99)00441-6
   Cicero AFG, 2016, PHYTOMEDICINE, V23, P1134, DOI 10.1016/j.phymed.2015.11.009
   Cicero AFG, 2016, ARCH MED SCI, V12, P507, DOI 10.5114/aoms.2016.59923
   CREAGER MA, 1992, J CLIN INVEST, V90, P1248, DOI 10.1172/JCI115987
   Das A, 2019, J AM COLL NUTR, V38, P526, DOI 10.1080/07315724.2018.1564088
   Davel AP, 2018, J AM HEART ASSOC, V7, DOI 10.1161/JAHA.117.007675
   Deanfield JE, 2007, CIRCULATION, V115, P1285, DOI 10.1161/CIRCULATIONAHA.106.652859
   Demircan N, 2008, MED SCI MONITOR, V14, pCR97
   ELLMAN GL, 1959, ARCH BIOCHEM BIOPHYS, V82, P70, DOI 10.1016/0003-9861(59)90090-6
   Endo J, 2016, J CARDIOL, V67, P22, DOI 10.1016/j.jjcc.2015.08.002
   Fahs CA, 2010, APPL PHYSIOL NUTR ME, V35, P294, DOI 10.1139/H10-020
   Goutzourelas N, 2018, EXP THER MED, V16, P635, DOI 10.3892/etm.2018.6204
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Guerrero-Romero F, 2006, DIABETES-METAB RES, V22, P471, DOI 10.1002/dmrr.644
   International Diabetes Federation, 2017, IDF CONS WORLDW DEF
   Jialal I, 2016, CLIN BIOCHEM, V49, P505, DOI 10.1016/j.clinbiochem.2015.12.009
   Joukar S, 2014, CARDIOVASC TOXICOL, V14, P214, DOI 10.1007/s12012-014-9245-3
   Koh KK, 2008, INT J CARDIOL, V124, P149, DOI 10.1016/j.ijcard.2007.04.080
   Kressel G, 2009, ATHEROSCLEROSIS, V202, P263, DOI 10.1016/j.atherosclerosis.2008.04.012
   Lim S, 2014, REV ENDOCR METAB DIS, V15, P329, DOI 10.1007/s11154-014-9298-4
   Mackay I, 2012, ATHEROSCLEROSIS, V221, P514, DOI 10.1016/j.atherosclerosis.2011.12.041
   Maulucci G, 2018, J CLIN LIPIDOL, V12, P669, DOI 10.1016/j.jacl.2018.02.004
   Mendrick DL, 2018, TOXICOL SCI, V162, P36, DOI 10.1093/toxsci/kfx233
   Millasseau SC, 2002, CLIN SCI, V103, P371, DOI 10.1042/cs1030371
   Naidu MUR, 2007, INDIAN J PHARMACOL, V39, P168, DOI 10.4103/0253-7613.33439
   Naqshbandi A, 2013, HUM EXP TOXICOL, V32, P385, DOI 10.1177/0960327112438929
   NEATON JD, 1992, ARCH INTERN MED, V152, P1490, DOI 10.1001/archinte.152.7.1490
   Olijhoek JK, 2004, EUR HEART J, V25, P342, DOI 10.1016/j.ehj.2003.12.007
   Pingali U, 2020, DIABET METAB SYND OB, V13, P31, DOI 10.2147/DMSO.S220046
   Rambaran C, 2008, BRIT J CLIN PHARMACO, V65, P238, DOI 10.1111/j.1365-2125.2007.03006.x
   Rameshrad M, 2019, DARU, V27, P341, DOI 10.1007/s40199-019-00238-7
   Sawada T, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-016-0437-y
   Schiano V, 2008, CLIN NUTR, V27, P241, DOI 10.1016/j.clnu.2007.11.007
   Shidfar F, 2008, East Mediterr Health J, V14, P305
   Skulas-Ray AC, 2011, AM J CLIN NUTR, V93, P243, DOI 10.3945/ajcn.110.003871
   Sorto-Gomez Tania E, 2016, Am J Neurodegener Dis, V5, P145
   Sun Ya-xun, 2006, Zhejiang Da Xue Xue Bao Yi Xue Ban, V35, P315
   Usharani P, 2017, INT J PHARM SCI RES, V8, P2267, DOI 10.13040/IJPSR.0975-8232.8(5).2267-76
   Usharani P, 2014, INT J PHARM SCI RES, V5, P2687, DOI 10.13040/IJPSR.0975-8232.5(6).2687-97
   Usharani P, 2013, DIABET METAB SYND OB, V6, P275, DOI 10.2147/DMSO.S46341
   Verma S, 2003, CIRCULATION, V108, P2054, DOI 10.1161/01.CIR.0000089191.72957.ED
   Vidyasagar J., 2004, Indian Journal of Pharmacology, V36, P76
   Wilson PWF, 2005, CIRCULATION, V112, P3066, DOI 10.1161/CIRCULATIONAHA.105.539528
   Wong CY, 2010, DIABETIC MED, V27, P54, DOI 10.1111/j.1464-5491.2009.02869.x
   World Med Assoc, 2013, JAMA-J AM MED ASSOC, V310, P2191, DOI 10.1001/jama.2013.281053
   Yamada H, 2008, ARTERIOSCL THROM VAS, V28, P2173, DOI 10.1161/ATVBAHA.108.171736
   Yao DD, 2004, MICROCHIM ACTA, V147, P1, DOI 10.1007/s00604-004-0212-8
   Yokoyama Mitsuhiro, 2009, Nihon Ronen Igakkai Zasshi, V46, P22
   Zafar U, 2018, HORM-INT J ENDOCRINO, V17, P299, DOI 10.1007/s42000-018-0051-3
NR 56
TC 1
Z9 1
U1 2
U2 10
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD JUN 25
PY 2021
VL 2021
AR 2972610
DI 10.1155/2021/2972610
PG 12
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA TH1SI
UT WOS:000671874500001
PM 34257675
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Foss-Freitas, MC
   Ferraz, RC
   Monteiro, LZ
   Gomes, PM
   Iwakura, R
   de Freitas, LCC
   Foss, MC
AF Foss-Freitas, Maria C.
   Ferraz, Rafael C.
   Monteiro, Luciana Z.
   Gomes, Patricia M.
   Iwakura, Ricardo
   de Freitas, Luiz Carlos C.
   Foss, Milton C.
TI Endoplasmic reticulum stress activation in adipose tissue induces
   metabolic syndrome in individuals with familial partial lipodystrophy of
   the Dunnigan type
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Familial partial lipodystrophy; Dunnigan type; Endoplasmic reticulum
   stress; Insulin resistance
ID BLOOD MONONUCLEAR-CELLS; UNFOLDED PROTEIN RESPONSE;
   NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE; TRANSLATIONAL CONTROL;
   DIABETIC-PATIENTS; LINKS OBESITY; IN-VITRO; CHAPERONIN; COMPLEX
AB Background: Familial partial lipodystrophy of the Dunnigan type is one of the most common inherited lipodystrophies variables. These individuals have important metabolic disorders that cause predisposition to various diseases. In this study we aimed to demonstrate the relation between the metabolic abnormalities, inflammatory profile and the expression of genes involved in the activation of the endoplasmic reticulum stress (ERS) in subjects with FPLD.
   Methods: We evaluated 14 female FPLD patients and compared with 13 female healthy individuals. The subjects were paired with their respective BMI and age and categorized into two groups: Familial partial lipodystrophy of the Dunnigan type (FPLD) and control. Patients were fasted for 12 h before blood collection for measurement of HbA1c, glucose, insulin, lipids and inflammatory markers. Subcutaneous adipose tissue was collected by puncture aspiration of submental region during ambulatorial surgical aesthetic procedure.
   Results: We demonstrate that patients with FPLD show increased HbA1c (p < 0.01), fasting glucose (p < 0.002) and triglycerides (p < 0.005) while HDL/cholesterol (p < 0.001) was lower when compared to healthy individuals. We found that 64.2% FPLD patients had metabolic syndrome according to International Diabetes Federation definition. We also observe increased AUC of glucose (p < 0.001) and insulin during oGTT, featuring a frame of hyperglycemia and hyperinsulinemia, suggesting insulin resistance. Also we found hyperactivation of several genes responsible for ERS such as ATF-4 (p < 0.01), ATF-6 (p < 0.01), EIF2 alpha 3K (p < 0.005), CCT4 (p < 0.001), CHOP (p < 0.01), CALR (p < 0.001) and CANX (p < 0.005), that corroborate the idea that diabetes mellitus and metabolic syndrome are associated with direct damage to the endoplasmic reticulum homeostasis. Ultimately, we note that individuals with lipodystrophy have an increase in serum interleukins, keys of the inflammatory process, as IL-1 beta, TNF-alpha and IL-6 (p < 0.05 all), compared with healthy individuals, which can be the trigger to insulin resistance in this population.
   Conclusion: Individuals with FPLD besides having typical dysfunctions of metabolic syndrome, show a hyperactivation of ERS associated with increased systemic inflammatory profile, which together may explain the complex clinical aspect of this diseases.
C1 [Foss-Freitas, Maria C.; Ferraz, Rafael C.; Gomes, Patricia M.; Foss, Milton C.] Univ Sao Paulo, Sch Med Ribeirao Preto, Div Endocrinol & Metab, Dept Med, Ribeirao Preto, SP, Brazil.
   [Monteiro, Luciana Z.] Univ Brasilia UNB, Brasilia, DF, Brazil.
   [Iwakura, Ricardo; de Freitas, Luiz Carlos C.] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Opthalmol Otolaryngol Head & Neck Surg, Ribeirao Preto, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade de Brasilia; Universidade de Sao
   Paulo
RP Foss-Freitas, MC (corresponding author), Univ Sao Paulo, Sch Med Ribeirao Preto, Div Endocrinol & Metab, Dept Med, Ribeirao Preto, SP, Brazil.
EM crisfoss@fmrp.usp.br
RI Gomes, Patricia/D-7103-2019; Foss-Freitas, Maria/AAV-5971-2021; Conti de
   Freitas, Luiz Carlos/F-1226-2013; Ferraz-Bannitz, Rafael/C-2390-2018;
   Foss-Freitas, Maria Cristina/F-1197-2013
OI Conti de Freitas, Luiz Carlos/0000-0002-2153-6512; Ferraz-Bannitz,
   Rafael/0000-0003-4496-4883; Monteiro, Luciana/0000-0001-7484-1185;
   Foss-Freitas, Maria Cristina/0000-0002-1350-1125
FU FAEPA
FX FAEPA.
CR Benito Manuel, 2011, Archives of Physiology and Biochemistry, V117, P96, DOI 10.3109/13813455.2011.563748
   Beraldo RA, 2015, EUR J CLIN NUTR, V69, P274, DOI 10.1038/ejcn.2014.149
   Coe H, 2009, GEN PHYSIOL BIOPHYS, V28, pF96
   Dinges WL, 2005, J INVEST MED, V53, P15, DOI 10.2310/6650.2005.00001
   Donadille B, 2005, DIABETES METAB, V31, P527, DOI 10.1016/S1262-3636(07)70227-6
   Foss-Freitas MC, 2007, BRAZ J MED BIOL RES, V40, P671, DOI 10.1590/S0100-879X2006005000107
   Foss-Freitas MC, 2008, DIABETES RES CLIN PR, V82, P329, DOI 10.1016/j.diabres.2008.09.003
   Foss-Freitas MC, 2006, ANN NY ACAD SCI, V1079, P177, DOI 10.1196/annals.1375.027
   Foss-Freitas Maria Cristina, 2006, Sao Paulo Med. J., V124, P219, DOI 10.1590/S1516-31802006000400009
   Garg A, 2004, ENDOCRIN METAB CLIN, V33, P305, DOI 10.1016/j.ecl.2004.03.003
   Garg A, 2011, J CLIN ENDOCR METAB, V96, P3313, DOI 10.1210/jc.2011-1159
   Garg A, 2009, BBA-MOL CELL BIOL L, V1791, P507, DOI 10.1016/j.bbalip.2008.12.014
   Geloneze B, 2009, ARQ BRAS ENDOCRINOL, V53, P281, DOI 10.1590/S0004-27302009000200020
   Harding HP, 2001, MOL CELL, V7, P1153, DOI 10.1016/S1097-2765(01)00264-7
   Harding HP, 2002, ANNU REV CELL DEV BI, V18, P575, DOI 10.1146/annurev.cellbio.18.011402.160624
   HARING HU, 1985, J CELL BIOCHEM, V28, P171, DOI 10.1002/jcb.240280209
   Herbst KL, 2003, DIABETES CARE, V26, P1819, DOI 10.2337/diacare.26.6.1819
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Jacob KN, 2006, MOL GENET METAB, V87, P289, DOI 10.1016/j.ymgme.2005.10.018
   Kahn C Ronald, 2003, Exp Diabesity Res, V4, P169, DOI 10.1155/EDR.2003.169
   Kaneto H, 2005, J MOL MED, V83, P429, DOI 10.1007/s00109-005-0640-x
   Kaufman RJ, 1999, GENE DEV, V13, P1211, DOI 10.1101/gad.13.10.1211
   KUBOTA H, 1995, EUR J BIOCHEM, V230, P3, DOI 10.1111/j.1432-1033.1995.0003i.x
   Lima LM, 2007, ARQ BRAS ENDOCRINOL, V51, P956, DOI 10.1590/S0004-27302007000600010
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McNelis JC, 2014, IMMUNITY, V41, P36, DOI 10.1016/j.immuni.2014.05.010
   Monteiro Luciana Z, 2012, Indian J Endocrinol Metab, V16, P136, DOI 10.4103/2230-8210.91209
   Mori K, 2000, CELL, V101, P451, DOI 10.1016/S0092-8674(00)80855-7
   Ou HY, ENDOCRINOLOGY
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Peraldi P, 1996, J BIOL CHEM, V271, P13018, DOI 10.1074/jbc.271.22.13018
   Ron D, 2002, J CLIN INVEST, V110, P1383, DOI 10.1172/JCI200216784
   Sánchez P, 2015, J CLIN ENDOCR METAB, V100, pE964, DOI 10.1210/jc.2014-4528
   Sartipy P, 2003, J BIOL CHEM, V278, P52298, DOI 10.1074/jbc.M306922200
   Scheuner D, 2008, ENDOCR REV, V29, P317, DOI 10.1210/er.2007-0039
   Shen YH, 2004, MOL CELL BIOL, V24, P407, DOI 10.1128/MCB.24.1.407-419.2004
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Spiess C, 2004, TRENDS CELL BIOL, V14, P598, DOI 10.1016/j.tcb.2004.09.015
   Steppan CM, 2001, NATURE, V409, P307, DOI 10.1038/35053000
   STERNLICHT H, 1993, P NATL ACAD SCI USA, V90, P9422, DOI 10.1073/pnas.90.20.9422
   Yam AY, 2008, NAT STRUCT MOL BIOL, V15, P1255, DOI 10.1038/nsmb.1515
   Zhang YJ, 2017, J CELL MOL MED, V21, P3761, DOI 10.1111/jcmm.13285
NR 42
TC 13
Z9 13
U1 0
U2 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD FEB 9
PY 2018
VL 10
AR 6
DI 10.1186/s13098-017-0301-6
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FW1WS
UT WOS:000425091700001
PM 29449893
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Luo, ZC
   Fraser, WD
   Julien, P
   Deal, CL
   Audibert, F
   Smith, GN
   Xiong, X
   Walker, M
AF Luo, ZC
   Fraser, WD
   Julien, P
   Deal, CL
   Audibert, F
   Smith, GN
   Xiong, X
   Walker, M
TI Tracing the origins of "fetal origins" of adult diseases: Programming by
   oxidative stress?
SO MEDICAL HYPOTHESES
LA English
DT Article
ID DEPENDENT DIABETES-MELLITUS; LOW-BIRTH-WEIGHT; INSULIN-RESISTANCE;
   THRIFTY PHENOTYPE; BLOOD-PRESSURE; CHANGING PATTERNS; PRETERM INFANTS;
   UNITED-STATES; GROWTH; TRENDS
AB Too small size at birth (due to poor fetal growth and/or preterm delivery) has been associated with substantially elevated risks of the metabolic syndrome (dislipidemia, insulin resistance, hypertension), type 2 diabetes and cardiovascular disease in adulthood. The mechanisms of such "fetal origins" or "programming" of disease phenomenon remain unresolved. Too large size at birth seems also associated with an increased risk. Many known or suspected causes of or conditions associated with adverse (poor or excessive) fetal growth or preterm birth have been associated with oxidative stress. Plausibly, oxidative stress may be a common link underlying the superficial "programming" associations between adverse fetal growth or preterm birth and elevated risks of certain chronic diseases. The mechanisms of oxidative stress programming may be through directly modulating gene expression or indirectly through the effects of certain oxidized molecules. Experimental investigations have well demonstrated the rote of redox balance in modulating gene expression, and recent studies indicate that both the insulin functional axis and blood pressure could be sensitive targets to oxidative stress programming. Adverse programming may occur without affecting fetal growth, but more frequently among low birth weight infants merely because they more frequently experienced known or unknown conditions with oxidative insults. As oxidative stress levels are easily modifiable during pregnancy and early postnatal periods (which are plausible critical windows), the hypothesis, if proved valid, will suggest new measures that could be very helpful on fighting the increasing epidemic of the metabolic syndrome, type 2 diabetes and cardiovascular disease. Currently, there are several ongoing large randomized trials of antioxidant supplementation to counter oxidative stress during pregnancy for the prevention of preeclampsia. It would be invaluable if long-term follow-ups of infants born to women in such trials could be realized to test the oxidative stress programming hypothesis in such experimental trial settings. (c) 2005 Elsevier Ltd. All rights reserved.
C1 Univ Montreal, St Justine Hosp, Dept Obstet & Gynecol, Montreal, PQ H3T 1C5, Canada.
   Quebec Lipid Res Ctr, Laval, PQ, Canada.
   Univ Montreal, St Justine Hosp, Dept Pediat, Montreal, PQ, Canada.
   Queens Univ, Dept Obstet & Gynecol, Kingston, ON K7L 3N6, Canada.
   Tulane Univ, Dept Epidemiol, New Orleans, LA 70118 USA.
   Univ Ottawa, Dept Obstet & Gynecol, Ottawa, ON K1N 6N5, Canada.
C3 Universite de Montreal; Centre Hospitalier Universitaire Sainte-Justine;
   Universite de Montreal; Centre Hospitalier Universitaire Sainte-Justine;
   Queens University - Canada; Tulane University; University of Ottawa
RP Univ Montreal, St Justine Hosp, Dept Obstet & Gynecol, Room 4981,3175 Cote St Catherine, Montreal, PQ H3T 1C5, Canada.
EM zhong-cheng.luo@recherche-ste-justine.qc.ca
RI Luo, Zhong-Cheng/T-3882-2017; Audibert, François/AAL-1265-2020; Julien,
   Pierre/AGO-7542-2022; Smith, Graeme/ABB-6863-2021
OI Audibert, Francois/0000-0002-2697-3826; Smith,
   Graeme/0000-0002-3128-4523
CR Ananth CV, 2002, SEMIN PERINATOL, V26, P260, DOI 10.1053/sper.2002.34772
   Antonisamy B, 1996, J TROP PEDIATRICS, V42, P339, DOI 10.1093/tropej/42.6.339
   Arikan S, 2001, GYNECOL OBSTET INVES, V51, P145, DOI 10.1159/000052913
   Barford D, 2004, CURR OPIN STRUC BIOL, V14, P679, DOI 10.1016/j.sbi.2004.09.012
   BARKER DJP, 1993, DIABETOLOGIA, V36, P62, DOI 10.1007/BF00399095
   BARKER DJP, 1995, BRIT MED J, V311, P171, DOI 10.1136/bmj.311.6998.171
   Basu S, 2004, FREE RADICAL RES, V38, P105, DOI 10.1080/10715760310001646895
   Baydas G, 2002, ARCH MED RES, V33, P276, DOI 10.1016/S0188-4409(02)00356-9
   Bertram CE, 2001, BRIT MED BULL, V60, P103, DOI 10.1093/bmb/60.1.103
   Block G, 2002, AM J EPIDEMIOL, V156, P274, DOI 10.1093/aje/kwf029
   Branum AM, 2002, PAEDIATR PERINAT EP, V16, P8, DOI 10.1046/j.1365-3016.2002.00394.x
   Burke A, 2003, PROG CARDIOVASC DIS, V46, P79, DOI 10.1016/S0033-0620(03)00076-8
   Cianfarani S, 1999, ARCH DIS CHILD-FETAL, V81, pF71, DOI 10.1136/fn.81.1.F71
   Dabelea D, 1999, DIABETES CARE, V22, P944, DOI 10.2337/diacare.22.6.944
   Dröge W, 2002, PHYSIOL REV, V82, P47, DOI 10.1152/physrev.00018.2001
   Franco MD, 2002, J CARDIOVASC PHARM, V40, P501, DOI 10.1097/00005344-200210000-00002
   FRASER WD, 2003, INT TRIAL ANTIOXIDAN
   Frostegard Johan, 2002, Autoimmunity Reviews, V1, P233, DOI 10.1016/S1568-9972(02)00059-9
   Gluckman PD, 2004, SCIENCE, V305, P1733, DOI 10.1126/science.1095292
   Gupta Piyush, 2004, BMC Pediatr, V4, P14, DOI 10.1186/1471-2431-4-14
   HALES CN, 1992, DIABETOLOGIA, V35, P595, DOI 10.1093/ije/dyt133
   HALES CN, 1991, BMJ-BRIT MED J, V303, P1019, DOI 10.1136/bmj.303.6809.1019
   Hales CN, 2001, BRIT MED BULL, V60, P5, DOI 10.1093/bmb/60.1.5
   Hancock JT, 2001, BIOCHEM SOC T, V29, P345, DOI 10.1042/0300-5127:0290345
   Higdon JV, 2003, ARTERIOSCL THROM VAS, V23, P365, DOI 10.1161/01.ATV.0000063608.43095.E2
   Itabe H, 2003, BIOL PHARM BULL, V26, P1, DOI 10.1248/bpb.26.1
   Laloi C, 2004, CURR OPIN PLANT BIOL, V7, P323, DOI 10.1016/j.pbi.2004.03.005
   LAUNER LJ, 1993, BMJ-BRIT MED J, V307, P1451, DOI 10.1136/bmj.307.6917.1451
   Linning KD, 2004, PANCREAS, V29, pE64, DOI 10.1097/00006676-200410000-00015
   Lucas A, 1998, J NUTR, V128, p401S, DOI 10.1093/jn/128.2.401S
   MCCANCE DR, 1994, BRIT MED J, V308, P942, DOI 10.1136/bmj.308.6934.942
   Morken NH, 2005, ACTA OBSTET GYN SCAN, V84, P558, DOI 10.1111/j.0001-6349.2005.00765.x
   MORROW JD, 1992, PROSTAGLANDINS, V44, P155, DOI 10.1016/0090-6980(92)90077-7
   Ogita H, 2004, ENDOTHELIUM-J ENDOTH, V11, P123, DOI 10.1080/10623320490482664
   Peuchant E, 2004, CLIN BIOCHEM, V37, P293, DOI 10.1016/j.clinbiochem.2003.12.005
   Pratico D, 1996, J BIOL CHEM, V271, P14916, DOI 10.1074/jbc.271.25.14916
   Racasan S, 2004, HYPERTENSION, V44, P83, DOI 10.1161/01.HYP.0000133251.40322.20
   Raijmakers MTM, 2004, HYPERTENSION, V44, P374, DOI 10.1161/01.HYP.0000141085.98320.01
   Roberts JM, 2002, PLACENTA, V23, P359, DOI 10.1053/plac.2002.0819
   Schwartz R, 1999, DIABETES CARE, V22, P1201, DOI 10.2337/diacare.22.7.1201
   Singhal A, 2004, LANCET, V363, P1642, DOI 10.1016/S0140-6736(04)16210-7
   Singhal A, 2003, LANCET, V361, P1089, DOI 10.1016/S0140-6736(03)12895-4
   Singhal A, 2001, LANCET, V357, P413, DOI 10.1016/S0140-6736(00)04004-6
   Singhal A, 2004, LANCET, V363, P1571, DOI 10.1016/S0140-6736(04)16198-9
   Surkan PJ, 2004, OBSTET GYNECOL, V104, P720, DOI 10.1097/01.AOG.0000141442.59573.cd
   Turpaev KT, 2002, BIOCHEMISTRY-MOSCOW+, V67, P281, DOI 10.1023/A:1014819832003
   van der Vaart H, 2004, THORAX, V59, P713, DOI 10.1136/thx.2003.012468
   Wang XL, 2004, DIABETES, V53, P129, DOI 10.2337/diabetes.53.1.129
   Willcox JK, 2004, CRIT REV FOOD SCI, V44, P275, DOI 10.1080/10408690490468489
   Yajnik CS, 2004, J NUTR, V134, P205, DOI 10.1093/jn/134.1.205
NR 50
TC 182
Z9 211
U1 1
U2 13
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PY 2006
VL 66
IS 1
BP 38
EP 44
DI 10.1016/j.mehy.2005.08.020
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 994MR
UT WOS:000234036400006
PM 16198060
DA 2025-06-11
ER

PT J
AU Courties, A
   Sellam, J
AF Courties, Alice
   Sellam, Jeremie
TI Osteoarthritis and type 2 diabetes mellitus: What are the links?
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Review
DE Osteoarthritis; Metabolic syndrome; Diabetes mellitus; Oxidative stress;
   Glucose
ID GLYCATION END-PRODUCTS; HUMAN ARTICULAR CHONDROCYTES;
   NECROSIS-FACTOR-ALPHA; HIGH-FAT DIET; NF-KAPPA-B; HIGH GLUCOSE; HAND
   OSTEOARTHRITIS; KNEE OSTEOARTHRITIS; MESSENGER-RNA; UP-REGULATION
AB Osteoarthritis (OA) is the most frequent joint disorder and one of the leading cause of disability. During a long time, it was considered as the consequence of aging and mechanical stress on cartilage. Recent advances in the knowledge of OA have highlighted that it is a whole joint disease with early modifications of synovium and subchondral bone but also that it is associated with obesity and metabolic syndrome through systemic mechanisms. In the past year, type 2 diabetes has been described in two meta-analyzes as an independent risk factor for OA. In vivo models of diabetes corroborated epidemiological studies. Indeed, diabetic rodents display a spontaneous and a more severe experimental OA than their non-diabetic counterparts, which can be partially prevented by diabetes treatment (insulin, pioglitazone). The negative impact of diabetes on joints could be explain by the induction of oxidative stress and pro-inflammatory cytokines but also by advanced age products accumulation in joint tissues exposed to chronic high glucose concentration. Insulin resistance might also impair joint tissue because of a local insulin resistance of diabetic synovial membrane but also by the systemic low grade inflammation state related to obesity and insulin resistant state. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 DHU i2B, St Antoine Hosp, AP HP, Dept Rheumatol, Paris, France.
   Univ Paris 06, Sorbonne Univ, DHU i2B, Inserm UMR S 938, Paris, France.
C3 Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital
   Universitaire Saint-Antoine - APHP; Institut National de la Sante et de
   la Recherche Medicale (Inserm); Sorbonne Universite
RP Sellam, J (corresponding author), Hop St Antoine, Serv Rhumatol, 184 Rue Faubourg St Antoine, F-75012 Paris, France.
EM Jeremie.sellam@aphp.fr
FU ROAD network (Fondation Arthritis Jacques Courtin); French Society of
   Rheumatology; Assistance Publique des Hopitaux de Paris (AP-HP)
FX The present work was supported by the ROAD network (Fondation Arthritis
   Jacques Courtin). A. Courties was supported by the French Society of
   Rheumatology and the Assistance Publique des Hopitaux de Paris (AP-HP).
CR Aguiari P, 2008, P NATL ACAD SCI USA, V105, P1226, DOI 10.1073/pnas.0711402105
   Alvarez-Garcia O, 2014, ARTHRITIS RHEUMATOL, V66, P1779, DOI 10.1002/art.38399
   [Anonymous], ARTHRITIS RHEUMATOL
   Atayde SA, 2012, HISTOL HISTOPATHOL, V27, P1471, DOI 10.14670/HH-27.1471
   Bijlsma JWJ, 2011, LANCET, V377, P2115, DOI 10.1016/S0140-6736(11)60243-2
   Chen YJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0066611
   Chen YJ, 2015, J ORTHOP RES, V33, P373, DOI 10.1002/jor.22770
   CIMMINO MA, 1990, CLIN EXP RHEUMATOL, V8, P251
   Collins KH, 2015, OSTEOARTHR CARTILAGE, V23, P1989, DOI 10.1016/j.joca.2015.03.014
   Courties A, 2015, OSTEOARTHR CARTILAGE, V23, P1955, DOI 10.1016/j.joca.2015.05.016
   Cramer C, 2010, STEM CELLS DEV, V19, P1875, DOI 10.1089/scd.2010.0009
   Dahaghin S, 2007, ANN RHEUM DIS, V66, P916, DOI 10.1136/ard.2005.045724
   Davies-Tuck ML, 2012, MATURITAS, V72, P373, DOI 10.1016/j.maturitas.2012.05.013
   El Karib AO, 2016, ARCH PHYSIOL BIOCHEM, V122, P148, DOI 10.3109/13813455.2016.1159698
   Eymard F, 2015, OSTEOARTHR CARTILAGE, V23, P851, DOI 10.1016/j.joca.2015.01.013
   Felson DT, 2003, ANN INTERN MED, V139, P330, DOI 10.7326/0003-4819-139-5_Part_1-200309020-00008
   Franke S, 2011, CLIN EXP RHEUMATOL, V29, P650
   Frey N, 2016, OSTEOARTHR CARTILAGE, V24, P1535, DOI 10.1016/j.joca.2016.04.005
   Fu DP, 2016, ANN CLIN LAB SCI, V46, P353
   Garessus EDG, 2016, OSTEOARTHR CARTILAGE, V24, P1541, DOI 10.1016/j.joca.2016.04.007
   Gómez R, 2011, ANN RHEUM DIS, V70, P2052, DOI 10.1136/ard.2010.145672
   Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
   Griffin TM, 2012, ARTHRITIS RHEUM-US, V64, P443, DOI 10.1002/art.33332
   Griffin TM, 2009, ARTHRITIS RHEUM-US, V60, P2935, DOI 10.1002/art.24854
   Gu HL, 2016, NUTRIENTS, V8, DOI 10.3390/nu8040233
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   HOTAMISLIGIL GS, 1995, J CLIN INVEST, V95, P2409, DOI 10.1172/JCI117936
   Huang ZM, 2016, OSTEOARTHR CARTILAGE, V24, P1246, DOI 10.1016/j.joca.2016.02.009
   Huang ZY, 2016, OSTEOARTHRITIS CARTI
   Hui W, 2012, ANN RHEUM DIS, V71, P455, DOI 10.1136/annrheumdis-2011-200372
   Hussain SM, 2014, SEMIN ARTHRITIS RHEU, V43, P429, DOI 10.1016/j.semarthrit.2013.07.013
   Laiguillon MC, 2015, OSTEOARTHR CARTILAGE, V23, P1513, DOI 10.1016/j.joca.2015.04.026
   Laiguillon MC, 2014, ARTHRITIS RES THER, V16, DOI 10.1186/ar4467
   Louati K, 2015, RMD OPEN, V1, DOI 10.1136/rmdopen-2015-000077
   Magnusson K, 2016, OSTEOARTHR CARTILAGE, V24, pS209, DOI 10.1016/j.joca.2016.01.406
   Magnusson K, 2015, ARTHRIT CARE RES, V67, P187, DOI 10.1002/acr.22460
   Mobasheri A, 2002, CELL BIOL INT, V26, P297, DOI 10.1006/cbir.2001.0850
   Mooney RA, 2011, ARTHRITIS RES THER, V13, DOI 10.1186/ar3529
   Nielen JTH, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000003739
   Onur T, 2014, BONE JOINT RES, V3, P203, DOI 10.1302/2046-3758.36.2000244
   Oren TW, 2011, J REHABIL RES DEV, V48, P1195, DOI 10.1682/JRRD.2010.09.0186
   Puenpatom RA, 2009, POSTGRAD MED, V121, P9, DOI 10.3810/pgm.2009.11.2073
   Rasheed Z, 2012, BBA-MOL CELL RES, V1823, P2179, DOI 10.1016/j.bbamcr.2012.08.021
   Rasheed Z, 2011, RHEUMATOLOGY, V50, P838, DOI 10.1093/rheumatology/keq380
   Ribeiro M, 2016, OSTEOARTHR CARTILAGE, V24, P731, DOI 10.1016/j.joca.2015.10.017
   Ribeiro M, 2016, OSTEOARTHRITIS CARTI
   Rosa SC, 2011, J CELL BIOCHEM, V112, P2813, DOI 10.1002/jcb.23196
   Rosa SC, 2009, ARTHRITIS RES THER, V11, DOI 10.1186/ar2713
   Schett G, 2013, DIABETES CARE, V36, P403, DOI 10.2337/dc12-0924
   Sellam J, 2010, NAT REV RHEUMATOL, V6, P625, DOI 10.1038/nrrheum.2010.159
   Shikhman AR, 2001, J IMMUNOL, V167, P7001, DOI 10.4049/jimmunol.167.12.7001
   Simopoulou T, 2007, OSTEOARTHR CARTILAGE, V15, P872, DOI 10.1016/j.joca.2007.01.018
   Tang CH, 2007, J IMMUNOL, V179, P5483, DOI 10.4049/jimmunol.179.8.5483
   Tomi AL, 2016, ANN RHEUM DIS
   Tong KM, 2011, J CELL BIOCHEM, V112, P1431, DOI 10.1002/jcb.23059
   Tsai CH, 2013, BBA-GEN SUBJECTS, V1830, P2649, DOI 10.1016/j.bbagen.2012.12.017
   Tsai TL, 2013, OSTEOARTHR CARTILAGE, V21, P368, DOI 10.1016/j.joca.2012.11.001
   Vaamonde-Garcia C, 2015, ARTHRITIS RHEUMA S10, V67
   Visser AW, 2015, ANN RHEUM DIS, V74, P1842, DOI 10.1136/annrheumdis-2013-205012
   WAINE H, 1961, Tufts Folia Med, V7, P13
   Wang JY, 2016, GENET MOL RES, V15, DOI 10.4238/gmr.15037753
   Wang Y, 2008, OSTEOARTHR CARTILAGE, V16, P579, DOI 10.1016/j.joca.2007.09.007
   Wang ZJ, 2016, ACTA MATER, V121, P78, DOI 10.1016/j.actamat.2016.08.085
   Wen CY, 2013, OSTEOARTHR CARTILAGE, V21, P1716, DOI 10.1016/j.joca.2013.06.027
   Williams MF, 2016, J DIABETES COMPLICAT, V30, P944, DOI 10.1016/j.jdiacomp.2016.02.016
   Woolf AD, 2003, B WORLD HEALTH ORGAN, V81, P646
   Wu CL, 2015, ANN RHEUM DIS, V74, P2076, DOI 10.1136/annrheumdis-2014-205601
   Yang S, 2015, ANN RHEUM DIS, V74, P595, DOI 10.1136/annrheumdis-2013-204355
   Yoshimura N, 2012, OSTEOARTHR CARTILAGE, V20, P1217, DOI 10.1016/j.joca.2012.06.006
   Yusuf E, 2010, ANN RHEUM DIS, V69, P761, DOI 10.1136/ard.2008.106930
   Zhang ZQ, 2010, ARTHRITIS RHEUM-US, V62, P1993, DOI 10.1002/art.27473
   Zhang ZJ, 2014, INT J MOL SCI, V15, P17242, DOI 10.3390/ijms151017242
NR 72
TC 116
Z9 127
U1 0
U2 23
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD DEC
PY 2016
VL 122
BP 198
EP 206
DI 10.1016/j.diabres.2016.10.021
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EF6TH
UT WOS:000390463200025
PM 27889689
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Coplan, JD
   Kolavennu, V
   Abdallah, CG
   Mathew, SJ
   Perera, TD
   Pantol, G
   Carpenter, D
   Tang, C
AF Coplan, Jeremy D.
   Kolavennu, Venu
   Abdallah, Chadi G.
   Mathew, Sanjay J.
   Perera, Tarique D.
   Pantol, Gustavo
   Carpenter, David
   Tang, Cheuk
TI Patterns of anterior versus posterior white matter fractional
   anistotropy concordance in adult nonhuman primates: Effects of early
   life stress
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
ID CORTICOTROPIN-RELEASING-FACTOR; CORPUS-CALLOSUM; GENERALIZED ANXIETY;
   METABOLIC SYNDROME; CHRONIC PAIN; CHILD-ABUSE; DIFFUSION; DEPRESSION;
   RILUZOLE; DISORDER
AB Introduction: Functional neuroimaging studies report global prefrontal dysconnectivity in mood disorders, supporting the notion of widespread disruptions in brain networks. Microscopic alterations in white matter (WM) tracts - which possess neuroplastic properties and play a central role in brain connectivity are interrogated herein in the context of brain dysconnectivity. Early life stress (ELS), an antecedent to human mood disorders, induces WM alterations in volumetrics and integrity. We hypothesized that nonhuman primate infants exposed to ELS would exhibit persistent impairments in both frontal and posterior concordance of WM integrity, therefore contributing to global brain dysconnectivity.
   Methods: Using a 3T MRI, diffusion tensor imaging (DTI) was performed on 21 adult male Bonnet macaques, 12 of whom had been raised under variable foraging demand (VFD) conditions and nine of whom had been raised under normative conditions (Non-VFD). As representative of anterior regions, fractional anisotropy (FA) concordance between anterior corpus callosum (ACorpusC) and anterior limb of the internal capsule (ALIC) was examined. For posterior regions, FA concordance between posterior corpus callosum (PCorpusC) and posterior limb of the internal capsule (PLICA) and between PCorpusC and occipital WM was examined. Examination of posterior FA was explored in the context of frontal markers of neuroplasticity.
   Results: A concordant relationship for FA between left ALIC and ACorpusC was evident in Non-VFD-reared subjects, but significantly absent in VFD-reared subjects. For left posterior regions, FA concordance between PLICA and PCorpusC and occipital WM and PCorpusC was evident in VFD-reared and not Non-VFDreared subjects. The posterior concordance in VFD was significantly distinguishable from the deficit in anterior concordance FA in VFD.
   Conclusions: The findings support the view that disrupted emotional integrity of the maternal-infant attachment process affects normative synchronous development of frontal white matter tracts but creates errant posterior concordance and also disrupts an inverse relationship between posterior white matter tracts and markers of neuroplasticity. We provide preliminary evidence that a concordant relationship between capsular-callosal FA may become discordant, providing a putative mechanism for prefrontal functional brain dysconnectivity. Published by Elsevier B.V.
C1 [Coplan, Jeremy D.] Suny Downstate Med Ctr, Dept Psychiat & Behav Sci, Brooklyn, NY 11203 USA.
   [Kolavennu, Venu] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA.
   [Abdallah, Chadi G.] VA Natl Ctr PTSD, Clin Neurosci Div, West Haven, CT USA.
   [Mathew, Sanjay J.] Michael E Debakey VA Med Ctr, Mental Hlth Care Line, Houston, TX USA.
   [Perera, Tarique D.] Columbia Univ, Dept Psychiat, Coll Phys & Surg, New York State Psychiat Inst, New York, NY USA.
   [Pantol, Gustavo; Carpenter, David; Tang, Cheuk] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
   [Pantol, Gustavo; Carpenter, David; Tang, Cheuk] Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY 10029 USA.
   [Pantol, Gustavo; Carpenter, David; Tang, Cheuk] Icahn Sch Med Mt Sinai, Dept Radiol, New York, NY 10029 USA.
   [Mathew, Sanjay J.] Baylor Coll Med, Menninger Dept Psychiat, Houston, TX 77030 USA.
C3 State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University; Yale University; Baylor College of Medicine; Baylor
   College Medical Hospital; Columbia University; New York State Psychiatry
   Institute; Icahn School of Medicine at Mount Sinai; Icahn School of
   Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Baylor
   College of Medicine
RP Coplan, JD (corresponding author), Suny Downstate Med Ctr, Box 120,450 Clarkson Ave, Brooklyn, NY 11203 USA.
EM Jeremy.Coplan@Downstate.edu
RI Mathew, Sanjay/J-2830-2014; Abdallah, Chadi/M-9969-2017
OI Abdallah, Chadi/0000-0001-5783-6181
FU Pfizer Pharmaceuticals; GSK; Corcept; Neurocrine; Allergan; AstraZeneca;
   Bristol-Myers Squibb; Cephalon, Inc.; Johnson Johnson; Naurex; Noven;
   Roche; Takeda; National Institutes of Health (NIH)/National Institute of
   Mental Health (NIMH) [R01MH081870]; NIH National Center for Advancing
   Translational Sciences [UL1TR000067]; Department of Veterans Affairs;
   NARSAD Independent Investigator Award
FX Dr Coplan is a speaker for Pfizer, Forest, BMS, GSK, Eli Lilly and
   Sunovion. He has received grants from Pfizer Pharmaceuticals, GSK,
   Corcept and Neurocrine. He has served on the advisory board of Pfizer,
   Otsuka, Lundbeck and Corcept.Dr. Mathew has received consulting fees or
   research support from Allergan, AstraZeneca, Bristol-Myers Squibb,
   Cephalon, Inc., Corcept, Johnson & Johnson, Naurex, Noven, Roche, and
   Takeda. The ketamine research was supported by National Institutes of
   Health (NIH)/National Institute of Mental Health (NIMH) grant
   R01MH081870, UL1TR000067 from the NIH National Center for Advancing
   Translational Sciences, Department of Veterans Affairs, and a NARSAD
   Independent Investigator Award, and supported with resources and the use
   of facilities at the Michael E. DeBakey VA Medical Center, Houston, TX.
CR Abdallah CG, 2014, PSYCHOTHER PSYCHOSOM, V83, P298, DOI 10.1159/000361078
   Abdallah CG, 2013, EUR NEUROPSYCHOPHARM, V23, P276, DOI 10.1016/j.euroneuro.2012.05.009
   Abdallah CG, 2012, NEUROSCI LETT, V530, P103, DOI 10.1016/j.neulet.2012.09.054
   Ackerman PT, 1998, CHILD ABUSE NEGLECT, V22, P759, DOI 10.1016/S0145-2134(98)00062-3
   Agartz I, 2001, NEUROREPORT, V12, P2251, DOI 10.1097/00001756-200107200-00041
   Anticevic A, 2014, BIOL PSYCHIAT, V75, P595, DOI 10.1016/j.biopsych.2013.10.021
   Anticevic A, 2013, BIOL PSYCHIAT, V73, P565, DOI 10.1016/j.biopsych.2012.07.031
   Barr CS, 2004, BIOL PSYCHIAT, V55, P733, DOI 10.1016/j.biopsych.2003.12.008
   Beaulieu C, 2002, NMR BIOMED, V15, P435, DOI 10.1002/nbm.782
   Bengtsson SL, 2005, NAT NEUROSCI, V8, P1148, DOI 10.1038/nn1516
   Brennan BP, 2010, NEUROPSYCHOPHARMACOL, V35, P834, DOI 10.1038/npp.2009.191
   Carlson Paul J, 2006, NeuroRx, V3, P22, DOI 10.1016/j.nurx.2005.12.009
   Choi S, 2015, J AFFECT DISORDERS, V172, P74, DOI 10.1016/j.jad.2014.09.042
   COHEN J, 1973, EDUC PSYCHOL MEAS, V33, P107, DOI 10.1177/001316447303300111
   Coplan JD, 2005, CNS SPECTRUMS, V10, P530, DOI 10.1017/S109285290001018X
   Coplan JD, 1996, P NATL ACAD SCI USA, V93, P1619, DOI 10.1073/pnas.93.4.1619
   Coplan JD, 1995, PSYCHIAT CLIN N AM, V18, P727, DOI 10.1016/S0193-953X(18)30020-0
   Coplan JD, 2014, FRONT BEHAV NEUROSCI, V8, DOI 10.3389/fnbeh.2014.00440
   Coplan JD, 2014, NEURAL PLAST, V2014, DOI 10.1155/2014/917981
   Coplan JD, 2014, FRONT BEHAV NEUROSCI, V8, DOI 10.3389/fnbeh.2014.00342
   Coplan JD, 2011, PHYSIOL BEHAV, V103, P535, DOI 10.1016/j.physbeh.2011.03.020
   Coplan JD, 2010, NEUROSCI LETT, V480, P93, DOI 10.1016/j.neulet.2010.06.012
   Danese A, 2008, ARCH GEN PSYCHIAT, V65, P409, DOI 10.1001/archpsyc.65.4.409
   Danese A, 2009, ARCH PEDIAT ADOL MED, V163, P1135, DOI 10.1001/archpediatrics.2009.214
   De Bellis M.D., 1994, CHILD ADOL PSYCH CL, V3, P663
   Du YZ, 2003, DEV NEUROSCI-BASEL, V25, P116, DOI 10.1159/000072261
   Du YZ, 2006, MOL CELL NEUROSCI, V31, P366, DOI 10.1016/j.mcn.2005.11.001
   Efron B., 2012, J AM STAT ASSOC, V99, P96
   Foong J, 2002, NEUROREPORT, V13, P333, DOI 10.1097/00001756-200203040-00017
   Gonzalez A, 2012, J PSYCHIATR RES, V46, P1475, DOI 10.1016/j.jpsychires.2012.08.004
   Hasan KM, 2004, MAGN RESON MED, V51, P413, DOI 10.1002/mrm.10682
   Hepgul N, 2012, PSYCHOL MED, V42, P1893, DOI 10.1017/S0033291711002947
   Hosang GM, 2013, CHILD ABUSE NEGLECT, V37, P374, DOI 10.1016/j.chiabu.2012.09.018
   Jackowski A, 2011, PSYCHIAT RES-NEUROIM, V192, P37, DOI 10.1016/j.pscychresns.2010.11.006
   Jackowski AP, 2008, PSYCHIAT RES-NEUROIM, V162, P256, DOI 10.1016/j.pscychresns.2007.08.006
   Kaufman D, 2005, J CLIN ENDOCR METAB, V90, P404, DOI 10.1210/jc.2004-0452
   Kaufman J, 2006, BIOL PSYCHIAT, V59, P673, DOI 10.1016/j.biopsych.2005.10.026
   Kendler KS, 2004, PSYCHOL MED, V34, P1475, DOI 10.1017/S003329170400265X
   Liu D, 1997, SCIENCE, V277, P1659, DOI 10.1126/science.277.5332.1659
   Liu F, 2010, BRAIN RES, V1343, P37, DOI 10.1016/j.brainres.2010.04.064
   Mathew SJ, 2005, AM J PSYCHIAT, V162, P2379, DOI 10.1176/appi.ajp.162.12.2379
   Mathew SJ, 2003, BIOL PSYCHIAT, V54, P727, DOI 10.1016/S0006-3223(03)00004-0
   McTigue DM, 2001, J NEUROSCI, V21, P3392, DOI 10.1523/JNEUROSCI.21-10-03392.2001
   Meaney Michael J, 2005, Dialogues Clin Neurosci, V7, P103
   Moeller FG, 2005, NEUROPSYCHOPHARMACOL, V30, P610, DOI 10.1038/sj.npp.1300617
   Molteni R, 2004, NEUROSCIENCE, V123, P429, DOI 10.1016/j.neuroscience.2003.09.020
   Nobuhara K, 2004, NEUROPSYCHOBIOLOGY, V50, P48, DOI 10.1159/000077941
   Palaniyappan L, 2010, J MENT HEALTH, V19, P157, DOI 10.3109/09638230903469129
   Perera TD, 2007, J NEUROSCI, V27, P4894, DOI 10.1523/JNEUROSCI.0237-07.2007
   Perera TD, 2011, NEURAL PLAST, V2011, DOI 10.1155/2011/875307
   Plotsky PM, 2005, NEUROPSYCHOPHARMACOL, V30, P2192, DOI 10.1038/sj.npp.1300769
   Putnam MC, 2010, J COGNITIVE NEUROSCI, V22, P1662, DOI 10.1162/jocn.2009.21290
   Roceri M, 2004, BIOL PSYCHIAT, V55, P708, DOI 10.1016/j.biopsych.2003.12.011
   ROSENBLUM LA, 1984, CHILD DEV, V55, P305, DOI 10.2307/1129854
   Rosenblum LA, 2001, DEV PSYCHOBIOL, V39, P40, DOI 10.1002/dev.1026
   Saariaho TH, 2011, SCAND J PSYCHOL, V52, P146, DOI 10.1111/j.1467-9450.2010.00849.x
   Salat DH, 2005, ANN NY ACAD SCI, V1064, P37, DOI 10.1196/annals.1340.009
   Sullivan GM, 1999, BIOL PSYCHIAT, V46, P1205, DOI 10.1016/S0006-3223(99)00246-2
   van der Kolk BA, 2003, CHILD ADOL PSYCH CL, V12, P293, DOI 10.1016/S1056-4993(03)00003-8
   Walsh CA, 2007, J INTERPERS VIOLENCE, V22, P1536, DOI 10.1177/0886260507306484
   Wang LF, 2014, HUM BRAIN MAPP, V35, P1154, DOI 10.1002/hbm.22241
   Wong AW, 2013, J NEUROSCI, V33, P4947, DOI 10.1523/JNEUROSCI.3990-12.2013
   Yang GJ, 2014, P NATL ACAD SCI USA, V111, P7438, DOI 10.1073/pnas.1405289111
   Zhang J, 2013, MOL PSYCHIATR, V18, P268, DOI 10.1038/mp.2012.46
NR 64
TC 8
Z9 8
U1 0
U2 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD MAR 1
PY 2016
VL 192
BP 167
EP 175
DI 10.1016/j.jad.2015.11.049
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA DB8UG
UT WOS:000368791600024
PM 26735328
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Fiedorowicz, JG
   Solomon, DA
   Endicott, J
   Leon, AC
   Li, CS
   Rice, JP
   Coryell, WH
AF Fiedorowicz, Jess G.
   Solomon, David A.
   Endicott, Jean
   Leon, Andrew C.
   Li, Chunshan
   Rice, John P.
   Coryell, William H.
TI Manic/Hypomanic Symptom Burden and Cardiovascular Mortality in Bipolar
   Disorder
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE adult; bipolar disorder; cardiovascular mortality; mania; prospective
   cohort study; risk factors
ID METABOLIC SYNDROME; RISK-FACTORS; MYOCARDIAL-INFARCTION;
   DIABETES-MELLITUS; WEIGHT-GAIN; FOLLOW-UP; SCHIZOAFFECTIVE DISORDER;
   ATYPICAL ANTIPSYCHOTICS; PSYCHIATRIC-DISORDERS; DEPRESSED-PATIENTS
AB Objectives: To compare the risk for cardiovascular mortality between bipolar I and bipolar II subtypes and determine correlates of cardiovascular mortality. Bipolar disorder conveys an increased risk of cardiovascular mortality. Methods: Participants with major affective disorders were recruited for the National Institute of Mental Health Collaborative Depression Study and followed prospectively for up to 25 years. A total of 435 participants met the diagnostic criteria for bipolar I (n = 288) or bipolar II (n = 147) disorder based on Research Diagnostic Criteria at intake and measures of psychiatric symptoms during follow-up. Diagnostic subtypes were contrasted by cardiovascular mortality risk using Cox proportional hazards regression. Affective symptom burden (the proportion of time with clinically significant manic/hypomanic or depressive symptoms) and treatment exposure were additionally included in the models. Results: Thirty-three participants died from cardiovascular causes. Participants with bipolar I disorder had more than double the cardiovascular mortality risk of those with bipolar It disorder, after controlling for age and gender (hazard ratio = 2.35, 95% Confidence Interval = 1.04-5.33; p = .04). The observed difference in cardiovascular mortality between these subtypes was at least partially confounded by the burden of clinically significant manic/hypomanic symptoms which predicted cardiovascular mortality independent of diagnosis, treatment exposure, age, gender, and cardiovascular risk factors at intake. Selective serotonin uptake inhibitors seemed protective although they were introduced late in follow-up. Depressive symptom burden was not related to cardiovascular mortality. Conclusions: Participants with bipolar I disorder may face a greater risk of cardiovascular mortality than those with bipolar II disorder. This difference in cardiovascular mortality risk may reflect manic/hypomanic symptom burden.
C1 [Fiedorowicz, Jess G.; Coryell, William H.] Univ Iowa Hosp & Clin, Roy J & Lucille A Carver Coll Med, Dept Psychiat, Iowa City, IA 52242 USA.
   [Solomon, David A.] Brown Univ, Dept Psychiat & Human Behav, Warren Alpert Med Sch, Providence, RI 02912 USA.
   [Endicott, Jean] Columbia Univ, Coll Phys & Surg, Dept Psychiat, New York, NY USA.
   [Endicott, Jean] New York State Psychiat Inst & Hosp, New York, NY 10032 USA.
   [Leon, Andrew C.; Li, Chunshan] Cornell Univ, Weill Med Coll, Dept Psychiat, New York, NY 10021 USA.
   [Rice, John P.] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA.
C3 University of Iowa; Brown University; Columbia University; New York
   State Psychiatry Institute; Cornell University; Weill Cornell Medicine;
   Washington University (WUSTL)
RP Fiedorowicz, JG (corresponding author), 200 Hawkins Dr W278GH, Iowa City, IA 52242 USA.
EM jess-fiedorowicz@uiowa.edu
RI Fiedorowicz, Jess/I-2512-2019
OI Fiedorowicz, Jess/0000-0003-2057-4071; coryell,
   william/0000-0003-3989-7276
FU National Institute of Mental Health [5R01MH025416, 5R01MH023864,
   5R01MH025478, 5R01MH025430, 5R01MH029957]; Nellie Ball Trust Research
   Fund; NARSAD Young Investigator Awar; Janserm Pharmaceutica; Abbott;
   Bristol-Meyers; Cyberonics; Intemeuron; Merck; Parkc-Davis; Pfizer;
   UpJohn; Wyeth-Ayerst;  [L30 MH075180]
FX This study was funded by Grant 5R01MH025416 to 33 (W.H.C.), Grant
   5R01MH023864 to 35 (J.E.), Grant 5R01MH025478 to 33 (M. Keller), Grant
   5R01MH025430 to 33 (J.P.R.), and Grant 5R01MH029957 to 30 (W.A.
   Scheftner) from the National Institute of Mental Health. Dr. Fiedorowicz
   is supported by Grant L30 MH075180 to 02, the Nellie Ball Trust Research
   Fund, and a NARSAD Young Investigator Award. He has also received
   research support for participating in a colleague's
   investigator-initiated study with Eli Lilly. Dr Solomon has served as an
   investigator for research funded by Janserm Pharmaceutica, as a
   consultant to Solvay Pharmaceuticals, Shire, and Novartis, and has
   served on the lecture bureaus of AstraZeneca, Pfizer, GlaxoSmithKline,
   and Shire. Dr. Endicott has received research support from Abbott,
   Bristol-Meyers, Cyberonics, Intemeuron, Merck, Parkc-Davis, Pfizer,
   UpJohn, and Wyeth-Ayerst; has served as a consultant or advisory board
   member for Abbott, AstraZeneca, Berlex, Bristol-Myers Squibb,
   Cyberonics, Eli Lilly, GlaxoSmithKIine, Novartis, Otsuka, Janssen,
   Ovation, Pfizer, Sanofi-Synthelabo Research, and Wyeth-Ayerst. Dr. Leon
   has served Data and Safety Monitoring Boards for Pfizer, Dainippon
   Sumitomo Pharma America, and Organon. He is a Consultant/Advisor to the
   Food and Drug Administration, NIMH, Cyberonics, and MedAvante. Dr. Rice
   is listed as an inventor on a patent (US 20070258898) held by Perlegen
   Sciences, covering the use of certain SNPs in determining the diagnosis,
   prognosis, and treatment of addiction. Mr. Li and Dr. Coryell have no
   disclosures or conflicts of interest to report.
CR Adland ML, 1947, PSYCHIAT QUART, V21, P38, DOI 10.1007/BF01674767
   Alstrom C.H., 1942, ACTA PSYCH NEUROL, V17, P1
   Angst F, 2002, J AFFECT DISORDERS, V68, P167, DOI 10.1016/S0165-0327(01)00377-9
   Angst Jules, 2005, Arch Suicide Res, V9, P279, DOI 10.1080/13811110590929488
   Arsenault-Lapierre G, 2004, BMC PSYCHIATRY, V4, DOI 10.1186/1471-244X-4-37
   Barefoot JC, 1996, CIRCULATION, V93, P1976, DOI 10.1161/01.CIR.93.11.1976
   Bell L., 1849, American Journal of Insanity, V6, P97
   Birkenaes AB, 2007, J CLIN PSYCHIAT, V68, P917, DOI 10.4088/JCP.v68n0614
   BLACK DW, 1987, J NERV MENT DIS, V175, P674, DOI 10.1097/00005053-198711000-00005
   BOTHWELL S, 1977, AM J ORTHOPSYCHIAT, V47, P231, DOI 10.1111/j.1939-0025.1977.tb00978.x
   BROADHEAD WE, 1990, JAMA-J AM MED ASSOC, V264, P2524, DOI 10.1001/jama.264.19.2524
   Cardenas J, 2008, J AFFECT DISORDERS, V106, P91, DOI 10.1016/j.jad.2007.05.030
   Carlson C, 2005, EUR NEUROPSYCHOPHARM
   Cassidy F, 1999, AM J PSYCHIAT, V156, P1417
   Chen YW, 1996, BIOL PSYCHIAT, V39, P896, DOI 10.1016/0006-3223(95)00295-2
   Coryell W, 1999, PSYCHOSOM MED, V61, P755, DOI 10.1097/00006842-199911000-00006
   CORYELL W, 1989, PSYCHOL MED, V19, P129, DOI 10.1017/S0033291700011090
   CORYELL W, 1987, AM J PSYCHIAT, V144, P309
   Coryell W, 2002, ACTA PSYCHIAT SCAND, V105, P218, DOI 10.1034/j.1600-0447.2002.1o127.x
   CORYELL W, 1993, AM J PSYCHIAT, V150, P720
   Derby IM, 1933, PSYCHIAT QUART, V7, P436, DOI 10.1007/BF01563541
   DINESEN H, 1984, ACTA NEUROL SCAND, V70, P65
   ENDICOTT J, 1978, ARCH GEN PSYCHIAT, V35, P837
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   Fiedorowicz JG, 2009, PSYCHOL MED, V39, P763, DOI 10.1017/S0033291708004078
   Fiedorowicz JG, 2008, ANN CLIN PSYCHIATRY, V20, P131, DOI 10.1080/10401230802177722
   FRASURESMITH N, 1995, CIRCULATION, V91, P999, DOI 10.1161/01.CIR.91.4.999
   Garcia-Portilla MP, 2008, J AFFECT DISORDERS, V106, P197, DOI 10.1016/j.jad.2007.06.002
   Gaulin BD, 1999, AM J PSYCHIAT, V156, P1270
   Gianfrancesco F, 2003, J CLIN PSYCHOPHARM, V23, P328, DOI 10.1097/01.jcp.0000085404.08426.3a
   Guo JJ, 2006, J CLIN PSYCHIAT, V67, P1055, DOI 10.4088/JCP.v67n0707
   Halperin Demian, 2007, Dialogues Clin Neurosci, V9, P47
   He Y, 2006, J AM COLL CARDIOL, V47, P1588, DOI 10.1016/j.jacc.2005.11.074
   Henderson DC, 2000, AM J PSYCHIAT, V157, P975, DOI 10.1176/appi.ajp.157.6.975
   Henderson DC, 2005, ARCH GEN PSYCHIAT, V62, P19, DOI 10.1001/archpsyc.62.1.19
   HERMIDA OG, 1994, BRIT J PHARMACOL, V111, P861, DOI 10.1111/j.1476-5381.1994.tb14817.x
   Huang TL, 2005, SCHIZOPHR RES, V80, P55, DOI 10.1016/j.schres.2005.05.001
   Johannessen L, 2006, J AFFECT DISORDERS, V95, P13, DOI 10.1016/j.jad.2006.03.027
   Judd LL, 2003, INT J NEUROPSYCHOPH, V6, P127, DOI 10.1017/S1461145703003341
   Judd LL, 2005, ARCH GEN PSYCHIAT, V62, P1322, DOI 10.1001/archpsyc.62.12.1322
   Judd LL, 2003, J AFFECT DISORDERS, V73, P19, DOI 10.1016/S0165-0327(02)00324-5
   Judd LL, 2002, ARCH GEN PSYCHIAT, V59, P530, DOI 10.1001/archpsyc.59.6.530
   Judd LL, 2003, ARCH GEN PSYCHIAT, V60, P261, DOI 10.1001/archpsyc.60.3.261
   Kallner G, 2000, PHARMACOPSYCHIATRY, V33, P8, DOI 10.1055/s-2000-7965
   KELLER MB, 1987, ARCH GEN PSYCHIAT, V44, P540
   Kilbourne AM, 2004, BIPOLAR DISORD, V6, P368, DOI 10.1111/j.1399-5618.2004.00138.x
   Kilbourne AM, 2007, PSYCHOSOMATICS, V48, P412, DOI 10.1176/appi.psy.48.5.412
   Kreyenbuhl J, 2006, J NERV MENT DIS, V194, P404, DOI 10.1097/01.nmd.0000221177.51089.7d
   Lambert BL, 2005, PHARMACOEPIDEM DR S, V14, P417, DOI 10.1002/pds.1092
   Laursen TM, 2007, J CLIN PSYCHIAT, V68, P899, DOI 10.4088/JCP.v68n0612
   Lespérance F, 2002, CIRCULATION, V105, P1049, DOI 10.1161/hc0902.104707
   Lin HC, 2008, PSYCHOSOM MED, V70, P73, DOI 10.1097/PSY.0b013e31815c1e93
   Lopez AD, 2005, GLOBALIZATION HEALTH, V1, DOI 10.1186/1744-8603-1-5
   Maggi S, 2006, J GERONTOL A-BIOL, V61, P505, DOI 10.1093/gerona/61.5.505
   McElroy SL, 2002, J CLIN PSYCHIAT, V63, P207, DOI 10.4088/JCP.v63n0306
   MURPHY JM, 1987, ARCH GEN PSYCHIAT, V44, P473
   ODEGARD ORNULF, 1951, ACTA GENET ET STATIST MED, V2, P141
   Ollendorf Daniel A, 2004, MedGenMed, V6, P5
   Ösby U, 2001, ARCH GEN PSYCHIAT, V58, P844, DOI 10.1001/archpsyc.58.9.844
   Osser DN, 1999, J CLIN PSYCHIAT, V60, P767, DOI 10.4088/JCP.v60n1109
   Pylvänen V, 2002, EPILEPSIA, V43, P514, DOI 10.1046/j.1528-1157.2002.31501.x
   RAY I, 1853, AM J INSANITY, V10, P95
   Teixeira PJR, 2007, REV BRAS PSIQUIATR, V29, P330, DOI 10.1590/S1516-44462007000400007
   RODRIGUEZGIL JE, 1993, ARCH BIOCHEM BIOPHYS, V301, P411, DOI 10.1006/abbi.1993.1164
   Rutledge T, 2006, ARCH GEN PSYCHIAT, V63, P874, DOI 10.1001/archpsyc.63.8.874
   Sachs G, 2006, BIPOLAR DISORD, V8, P175, DOI 10.1111/j.1399-5618.2006.00308.x
   Sernyak MJ, 2005, J CLIN PSYCHIAT, V66, P1463, DOI 10.4088/JCP.v66n1117
   Shah Amy, 2006, Ann Clin Psychiatry, V18, P239, DOI 10.1080/10401230600948423
   SHARMA R, 1994, J AFFECT DISORDERS, V31, P91, DOI 10.1016/0165-0327(94)90112-0
   Simon GE, 2006, ARCH GEN PSYCHIAT, V63, P824, DOI 10.1001/archpsyc.63.7.824
   SIMONSICK EM, 1995, PSYCHOSOM MED, V57, P427, DOI 10.1097/00006842-199509000-00003
   Simpson GM, 2005, AM J MANAG CARE, V11, pS235
   SPITZER RL, 1978, ARCH GEN PSYCHIAT, V35, P773, DOI 10.1001/archpsyc.1978.01770300115013
   Spivak B, 1999, CLIN NEUROPHARMACOL, V22, P98, DOI 10.1097/00002826-199903000-00006
   TABATA I, 1994, DIABETES, V43, P903, DOI 10.2337/diabetes.43.7.903
   Taylor CB, 2005, ARCH GEN PSYCHIAT, V62, P792, DOI 10.1001/archpsyc.62.7.792
   TSUANG MT, 1980, BRIT J PSYCHIAT, V136, P239, DOI 10.1192/bjp.136.3.239
   van Winkel R, 2008, BIPOLAR DISORD, V10, P342, DOI 10.1111/j.1399-5618.2007.00520.x
   VENDSBORG PB, 1976, ACTA PSYCHIAT SCAND, V53, P139, DOI 10.1111/j.1600-0447.1976.tb00067.x
   VESTERGAARD P, 1987, NEUROPSYCHOBIOLOGY, V17, P130, DOI 10.1159/000118351
   Volavka J, 2002, AM J PSYCHIAT, V159, P255, DOI 10.1176/appi.ajp.159.2.255
   WEEKE A, 1987, J AFFECT DISORDERS, V13, P287, DOI 10.1016/0165-0327(87)90049-8
   YATES WR, 1987, J AFFECT DISORDERS, V12, P129, DOI 10.1016/0165-0327(87)90004-8
   Yilmaz E, 2001, ACTA NEUROL BELG, V101, P217
   Yumru M, 2007, J AFFECT DISORDERS, V98, P247, DOI 10.1016/j.jad.2006.08.009
   ZILBER N, 1989, ACTA PSYCHIAT SCAND, V79, P248, DOI 10.1111/j.1600-0447.1989.tb10254.x
   Zipursky RB, 2005, BRIT J PSYCHIAT, V187, P537, DOI 10.1192/bjp.187.6.537
NR 87
TC 106
Z9 109
U1 2
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0033-3174
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JUL-AUG
PY 2009
VL 71
IS 6
BP 598
EP 606
DI 10.1097/PSY.0b013e3181acee26
PG 9
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 471JA
UT WOS:000268052100002
PM 19561163
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Demir, B
   Demir, E
   Aciksari, G
   Uygun, T
   Utku, IK
   Gedikbasi, A
   Caglar, I
   Pirhan, O
   Tureli, HO
   Oflar, E
   Ungan, I
   Ciftci, S
   Karakaya, O
AF Demir, Bulent
   Demir, Esra
   Aciksari, Gonul
   Uygun, Turgut
   Utku, Irem Kirac
   Gedikbasi, Asuman
   Caglar, IlkerMurat
   Pirhan, Osman
   Tureli, Hande Oktay
   Oflar, Ersan
   Ungan, Ismail
   Ciftci, Serkan
   Karakaya, Osman
TI The Association between the Epicardial Adipose Tissue Thickness and
   Oxidative Stress Parameters in Isolated Metabolic Syndrome Patients: A
   Multimarker Approach
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID SERUM PARAOXONASE; ARYLESTERASE ACTIVITIES; INSULIN-RESISTANCE; VISCERAL
   FAT; OBESITY; CHILDREN; DISEASE
AB The risk for cardiovascular diseases and type 2 diabetes mellitus significantly increases in the patient population with metabolic syndrome (MeS). The present study aimed to investigate the association between the epicardial adipose tissue thickness (EATT) and the oxidative stress parameters in MeS patients. The study included 181 patients as a patient group of 92 consecutive patients with MeS and a control group of 89 consecutive patients with similar age and gender. EATT was evaluated by transthoracic echocardiography. Serum levels of total oxidant status (TOS), total antioxidative capacity (TAS), paraoxonase-1 (PON-1), and arylesterase activities were measured. EATT was higher in the MeS group compared to the control group (6.0 +/- 2.0 mm and 4.0 +/- 1.0 mm, resp.; P < 0.001). The level of TOS was higher in the MeS group compared to the control group (P < 0.001). Additionally, the TAS level was higher in the MeS group compared to the control group (P < 0.001). Furthermore, the serum levels of PON-1 and arylesterase were lower in the MeS group compared to the control group (P < 0.001). EAT may cause an increased risk of cardiovascular diseases by leading to increased oxidative stress in patients with MeS.
C1 [Demir, Bulent; Uygun, Turgut; Caglar, IlkerMurat; Pirhan, Osman; Tureli, Hande Oktay; Oflar, Ersan; Ungan, Ismail; Ciftci, Serkan; Karakaya, Osman] Bakirkoy Dr Sadi Konuk Educ & Res Hosp, Dept Cardiol, TR-34156 Istanbul, Turkey.
   [Demir, Esra; Utku, Irem Kirac] Bakirkoy Dr Sadi Konuk Educ & Res Hosp, Dept Internal Med, TR-34156 Istanbul, Turkey.
   [Aciksari, Gonul] Istinye State Hosp, Dept Cardiol, Istanbul, Turkey.
   [Gedikbasi, Asuman] Bakirkoy Dr Sadi Konuk Educ & Res Hosp, Dept Biochem, TR-34156 Istanbul, Turkey.
C3 Bakirkoy Dr. Sadi Konuk Research & Training Hospital; Bakirkoy Dr. Sadi
   Konuk Research & Training Hospital; Istinye State Hospital; Bakirkoy Dr.
   Sadi Konuk Research & Training Hospital
RP Demir, B (corresponding author), Bakirkoy Dr Sadi Konuk Educ & Res Hosp, Dept Cardiol, Tevfik Saglam Caddesi 11, TR-34156 Istanbul, Turkey.
EM drbdmr06@hotmail.com
RI Gedikbasi, Asuman/AAE-3613-2020; Demir, Bulent/KVC-1688-2024; aciksari,
   gonul/LXW-1995-2024; Karakaya, Osman/KPB-5126-2024; kirac utku,
   irem/GPS-9145-2022; Pirhan, Osman/JAN-8491-2023
OI Aciksari, Gonul/0000-0002-8380-3065; Demir, Bulent/0000-0003-1767-408X
CR Alexopoulos N, 2014, ATHEROSCLEROSIS, V233, P104, DOI 10.1016/j.atherosclerosis.2013.12.023
   [Anonymous], 2005, IDF CONS WORLDW DEF
   Bertaso AG, 2013, ARQ BRAS CARDIOL, V101, pE18
   Blachnio-Zabielska AU, 2012, LIPIDS, V47, P1131, DOI 10.1007/s11745-012-3722-x
   Demircan N, 2008, MED SCI MONITOR, V14, pCR97
   Elnakish MT, 2013, J PATHOL, V231, P290, DOI 10.1002/path.4255
   Erel O, 2004, CLIN BIOCHEM, V37, P112, DOI 10.1016/j.clinbiochem.2003.10.014
   Erel O, 2005, CLIN BIOCHEM, V38, P1103, DOI 10.1016/j.clinbiochem.2005.08.008
   Ertem AG, 2014, ANATOL J CARDIOL, V14, P115, DOI 10.5152/akd.2014.4742
   Faienza MF, 2012, HORM RES PAEDIAT, V78, P158, DOI 10.1159/000342642
   Muñoz MJF, 2014, REV ESP CARDIOL, V67, P436, DOI [10.1016/j.rec.2013.10.011, 10.1016/j.recesp.2013.10.013]
   Fujita K, 2006, CIRC J, V70, P1437, DOI 10.1253/circj.70.1437
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Galili O, 2007, AM J PHYSIOL-HEART C, V292, pH904, DOI 10.1152/ajpheart.00628.2006
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hashemi M, 2011, EUR J ENDOCRINOL, V164, P219, DOI 10.1530/EJE-10-0881
   Hopps E, 2010, NUTR METAB CARDIOVAS, V20, P72, DOI 10.1016/j.numecd.2009.06.002
   Iacobellis G, 2005, CYTOKINE, V29, P251, DOI 10.1016/j.cyto.2004.11.002
   Jayakumari N, 2009, J CLIN BIOCHEM NUTR, V45, P278, DOI 10.3164/jcbn.08-255
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mazurek T, 2003, CIRCULATION, V108, P2460, DOI 10.1161/01.CIR.0000099542.57313.C5
   Onat A, 2007, ATHEROSCLEROSIS, V191, P182, DOI 10.1016/j.atherosclerosis.2006.03.012
   Ozturk E, 2011, INT J GYNECOL CANCER, V21, P149, DOI 10.1097/IGC.0b013e3182021c59
   Park JS, 2010, CARDIOVASC DIABETOL, V9, DOI 10.1186/1475-2840-9-29
   Pierdomenico SD, 2013, AM J CARDIOL, V111, P73, DOI 10.1016/j.amjcard.2012.08.044
   Rabkin SW, 2014, METAB SYNDR RELAT D, V12, P31, DOI 10.1089/met.2013.0107
   Salgado-Somoza A, 2010, AM J PHYSIOL-HEART C, V299, pH202, DOI 10.1152/ajpheart.00120.2010
   Sun MX, 2012, OBESITY, V20, P2233, DOI 10.1038/oby.2012.63
   Tabur S, 2010, EUR J ENDOCRINOL, V162, P535, DOI 10.1530/EJE-09-0732
   Torun E, 2014, J PEDIATR ENDOCR MET, V27, P667, DOI 10.1515/jpem-2013-0337
NR 32
TC 16
Z9 19
U1 0
U2 6
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2014
VL 2014
AR 954045
DI 10.1155/2014/954045
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AT6EY
UT WOS:000345033100001
PM 25530760
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Vieira, TD
   Freitas, FV
   Neto, LCBS
   Borçoi, AR
   Mendes, SO
   Olinda, AS
   Moreno, IAA
   Quaioto, BR
   de Souza, MLM
   Barbosa, WM
   Arpini, JK
   Sorroche, BP
   Pinheiro, JD
   Archanjo, AB
   dos Santos, JG
   Arantes, LMRB
   de Oliveira, DR
   da Silva, AMA
AF Vieira, Tamires dos Santos
   Freitas, Flavia Vitorino
   Neto, Luiz Claudio Barreto Silva
   Borcoi, Aline Ribeiro
   Mendes, Suzanny Oliveira
   Olinda, Amanda Sgrancio
   Moreno, Ivana Alece Arantes
   Quaioto, Barbara Risse
   de Souza, Marcele Lorentz Mattos
   Barbosa, Wagner Miranda
   Arpini, Juliana Kruger
   Sorroche, Bruna Pereira
   Pinheiro, Julia de Assis
   Archanjo, Anderson Barros
   dos Santos, Joaquim Gasparini
   Arantes, Lidia Maria Rebolho Batista
   de Oliveira, Daniela Rodrigues
   da Silva, Adriana Madeira Alvares
TI An industrialized diet as a determinant of methylation in the 1F region
   of the NR3C1 gene promoter
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE food consumption; lifestyle; metabolic stress; chronic diseases; diet's
   composition; epigenetic mechanisms; industrialized diet
ID GLUCOCORTICOID-RECEPTOR GENE; DEPRESSION INVENTORY-II; DNA METHYLATION;
   CHILDHOOD MALTREATMENT; METABOLIC SYNDROME; STRESS; PATTERNS; DISORDER;
   OBESITY; QUANTIFICATION
AB Background: Dietary composition can modify gene expression, favoring the development of chronic diseases via epigenetic mechanisms. Objective: Our study aimed to investigate the relationship between dietary patterns and NR3C1 gene methylation in users of the Brazilian Public Unified Health System (SUS). Methods: We recruited 250 adult volunteers and evaluated their socioeconomic status, psychosocial characteristics, lifestyle, and anthropometrics. Peripheral blood was collected and evaluated for cortisol levels, glycemia, lipid profile, and insulin resistance; methylation of CpGs 40-47 of the 1F region of the NR3C1 gene was also measured. Factors associated with degree of methylation were evaluated using generalized linear models (p < 0.05). Lifestyle variables and health variables were included as confounding factors. Results: The findings of our cross-sectional study indicated an association between NR3C1 DNA methylation and intake of processed foods. We also observed relevant associations of average NR3C1 DNA across the segment analyzed, methylation in component 1 (40-43), and methylation in component 2 (44-47) with a pattern of consumption of industrialized products in relation to BMI, serum cortisol levels, and lipid profile. These results may indicate a relationship between methylation and metabolic changes related to the stress response. Conclusion: These findings suggest an association of methylation and metabolic alterations with stress response. In addition, the present study highlights the significant role of diet quality as a stress-inducing factor that influences NR3C1 methylation. This relationship is further linked to changes in psychosocial factors, lifestyle choices, and cardiometabolic variables, including glucose levels, insulin resistance, and hyperlipidemia.
C1 [Vieira, Tamires dos Santos; Borcoi, Aline Ribeiro; Olinda, Amanda Sgrancio; Moreno, Ivana Alece Arantes; Quaioto, Barbara Risse; de Souza, Marcele Lorentz Mattos; Pinheiro, Julia de Assis; Archanjo, Anderson Barros; dos Santos, Joaquim Gasparini; da Silva, Adriana Madeira Alvares] Univ Fed Espirito Santo, Program Postgrad Biotechnol Renorbio, Vitoria, Brazil.
   [Freitas, Flavia Vitorino; Barbosa, Wagner Miranda] Univ Fed Espirito Santo, Dept Pharm & Nutr, Alegre, Brazil.
   [Neto, Luiz Claudio Barreto Silva] Univ Fed Espirito Santo, Program Postgrad Nutr & Hlth, Vitoria, Brazil.
   [Mendes, Suzanny Oliveira; da Silva, Adriana Madeira Alvares] Univ Fed Espirito Santo, Dept Morphol, Vitoria, Brazil.
   [Arpini, Juliana Kruger] Univ Fed Espirito Santo, Dept Biol, Alegre, Brazil.
   [Sorroche, Bruna Pereira; Arantes, Lidia Maria Rebolho Batista] Barretos Canc Hosp, Mol Oncol Res Ctr, Barretos, Brazil.
   [de Oliveira, Daniela Rodrigues] Coll Wisconsin, Dept Pharmacol & Med Toxicol, Milwaukee, WI USA.
C3 Universidade Federal do Espirito Santo; Universidade Federal do Espirito
   Santo; Universidade Federal do Espirito Santo; Universidade Federal do
   Espirito Santo; Universidade Federal do Espirito Santo; Hospital de
   Cancer de Barretos; Medical College of Wisconsin
RP Vieira, TD (corresponding author), Univ Fed Espirito Santo, Program Postgrad Biotechnol Renorbio, Vitoria, Brazil.
EM tamiresvieiraalim@gmail.com
RI Neto, Luiz/IWE-4412-2023; Álvares-da-Silva, Adriana/J-2912-2018;
   Sgrancio Olinda, Amanda/JXY-5673-2024; Quaioto, Bárbara/JCD-9609-2023;
   Archanjo, Anderson/Q-5245-2017; Borcoi, Aline/AAE-1281-2020; Pereira
   Sorroche, Bruna/ABA-2666-2020
OI Pereira Sorroche, Bruna/0000-0001-9802-8236
FU FAPES through the Research Programs of the Unified Health System - PPSUS
   [PPSUS 10/2013- 65883616/2014]; PPSUS [05/2015 - 59874713515/2016];
   FAPES/CNPq - PDCTR [11/2019- 557/2020]
FX This study received support from the Fundac & atilde;o de Amparo a
   Pesquisa e Inovac & atilde;o do Estado do Espirito Santo - FAPES through
   the Research Programs of the Unified Health System - PPSUS (PPSUS
   10/2013- 65883616/2014 and PPSUS 05/2015 - 59874713515/2016) and
   FAPES/CNPq - PDCTR (11/2019- 557/2020). We are grateful for the
   financial support provided by these organizations.r This study received
   support from the Fundac & atilde;o de Amparo a Pesquisa e Inovac &
   atilde;o do Estado do Espirito Santo - FAPES through the Research
   Programs of the Unified Health System - PPSUS (PPSUS 10/2013-
   65883616/2014 and PPSUS 05/2015 - 59874713515/2016) and FAPES/CNPq -
   PDCTR (11/2019- 557/2020). We are grateful for the financial support
   provided by these organizations.
CR Alegra-Torres JA, 2011, EPIGENOMICS-UK, V3, P267, DOI [10.2217/EPI.11.22, 10.2217/epi.11.22]
   Argentieri MA, 2017, EBIOMEDICINE, V18, P327, DOI 10.1016/j.ebiom.2017.03.044
   Arnau RC, 2001, HEALTH PSYCHOL, V20, P112, DOI 10.1037//0278-6133.20.2.112
   Ashwell M, 2005, INT J FOOD SCI NUTR, V56, P303, DOI 10.1080/09637480500195066
   Banatvala N, 2023, Noncommunicable Diseases: A Compendium
   Barchitta M, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081843
   Beck AT, 1996, J PERS ASSESS, V67, P588, DOI 10.1207/s15327752jpa6703_13
   Berry A, 2022, EUR J NEUROSCI, V55, P2326, DOI 10.1111/ejn.15181
   Booij L, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0119061
   Borçoi AR, 2021, STRESS, V24, P814, DOI 10.1080/10253890.2021.1923692
   Borcoi AR, 2020, J PSYCHIATR RES, V121, P24, DOI 10.1016/j.jpsychires.2019.10.011
   Braithwaite EC, 2015, EPIGENETICS-US, V10, P408, DOI 10.1080/15592294.2015.1039221
   Bustamante AC, 2016, J AFFECT DISORDERS, V206, P181, DOI 10.1016/j.jad.2016.07.038
   Canhada SL, 2023, DIABETES CARE, V46, P369, DOI 10.2337/dc22-1505
   Silva BCC, 2007, ARQ BRAS ENDOCRINOL, V51, P625, DOI 10.1590/S0004-27302007000400018
   Cattafesta M, 2019, CIENC SAUDE COLETIVA, V24, P3909, DOI 10.1590/1413-812320182410.31342017
   Chamberlain JA, 2018, AM J CLIN NUTR, V108, P611, DOI 10.1093/ajcn/nqy119
   Chau CMY, 2014, FRONT BEHAV NEUROSCI, V8, DOI 10.3389/fnbeh.2014.00409
   Colella S, 2003, BIOTECHNIQUES, V35, P146, DOI 10.2144/03351md01
   Crujeiras AB, 2017, SCI REP-UK, V7, DOI 10.1038/srep41903
   Daskalakis NP, 2014, FRONT NEUROSCI-SWITZ, V8, DOI 10.3389/fnins.2014.00369
   Pinheiro JD, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-86189-z
   Selem SSD, 2014, J ACAD NUTR DIET, V114, P1216, DOI 10.1016/j.jand.2014.01.007
   De Oliveira JEP., 2015, Diretrizes da Sociedade Brasileira de Diabetes: 2014-2015
   Di Sante J, 2018, PSYCHONEUROENDOCRINO, V97, P196, DOI 10.1016/j.psyneuen.2018.07.019
   Freitas FV, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0197699
   Gómez-Pérez D, 2021, INT J BEHAV MED, V28, P292, DOI 10.1007/s12529-020-09917-1
   Guerrero-Romero F, 2016, ARCH MED RES, V47, P382, DOI 10.1016/j.arcmed.2016.08.012
   Hamid Hamada, 2004, Transcult Psychiatry, V41, P487, DOI 10.1177/1363461504047931
   Hardin JW., 2012, Generalized Estimating Equations, V2nd, P277
   Hongyu K., 2016, ES - Engineering and Science, V1, P83
   IBGE, 2019, Pesquisa de Orcamentos Familiares, 2017-2018: Primeiros Resultados, P64
   Jia TY, 2021, MOL PSYCHIATR, V26, P3884, DOI 10.1038/s41380-019-0605-z
   Jones PA, 2001, SCIENCE, V293, P1068, DOI 10.1126/science.1063852
   Juruena Mario F, 2004, Braz. J. Psychiatry, V26, P189, DOI 10.1590/S1516-44462004000300009
   Kadam I, 2021, NUTRIENTS, V13, DOI 10.3390/nu13103555
   Kadayifci FZ, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19124055
   Kember RL, 2012, BRAIN BEHAV, V2, P455, DOI 10.1002/brb3.69
   Kino T, 2002, J ALLERGY CLIN IMMUN, V109, P609, DOI 10.1067/mai.2002. 123708
   Labonté B, 2014, TRANSL PSYCHIAT, V4, DOI 10.1038/tp.2014.3
   Lee J, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-82053-2
   Lopes ACS., 2010, NUTR PAUTA, V18, P40
   Mahmood S, 2013, J DEV ORIG HLTH DIS, V4, P479, DOI 10.1017/S2040174413000238
   [Anonymous], 2010, Arq. Bras. Cardiol., V95, pI, DOI [10.5935/abc.20160153, 10.5935/abc.20160152]
   Martín-Blanco A, 2014, J PSYCHIATR RES, V57, P34, DOI 10.1016/j.jpsychires.2014.06.011
   de Souza MLM, 2022, LIFE SCI, V309, DOI 10.1016/j.lfs.2022.120940
   McCabe CF, 2022, J NUTR BIOCHEM, V101, DOI 10.1016/j.jnutbio.2022.108938
   Melo Silvia Pereira da Silva de Carvalho, 2020, Rev. bras. epidemiol., V23, pe200036, DOI 10.1590/1980-549720200036
   Michels N, 2019, NUTR RES REV, V32, P282, DOI 10.1017/S0954422419000143
   Natale F, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11172661
   Nicoletti CF, 2020, EUR J CLIN NUTR, V74, P1345, DOI 10.1038/s41430-020-0660-1
   Nogueira VC, 2019, Cienc Saude Coletiva, V24, P761, DOI [10.1590/1413-81232018243.03362017, DOI 10.1590/1413-81232018243.03362017]
   NORGAN NG, 1988, ERGONOMICS, V31, P1493, DOI 10.1080/00140138808966796
   Obeid R, 2013, NUTRIENTS, V5, P3481, DOI 10.3390/nu5093481
   Oberlander TF, 2008, EPIGENETICS-US, V3, P97, DOI 10.4161/epi.3.2.6034
   Palma-Gudiel H, 2015, NEUROSCI BIOBEHAV R, V55, P520, DOI 10.1016/j.neubiorev.2015.05.016
   Park JH, 2018, INT J OBESITY, V42, P244, DOI 10.1038/ijo.2017.203
   Perng W, 2014, NUTR METAB CARDIOVAS, V24, P614, DOI 10.1016/j.numecd.2013.11.011
   Perroud N, 2014, BRIT J PSYCHIAT, V204, P30, DOI 10.1192/bjp.bp.112.120055
   Pitanga Francisco José Gondim, 2004, Rev. bras. epidemiol., V7, P259
   PNS - Pesquisa Nacional de Saude, 2023, About us
   Portela A, 2010, NAT BIOTECHNOL, V28, P1057, DOI 10.1038/nbt.1685
   Quinta F., 2019, Guia Alimentar para a Populacao Brasileira. Nupens | Nucleo de Pesquisas Epidemiologicas em Nutricao e Saude
   Ricci C, 2019, INT J FOOD SCI NUTR, V70, P738, DOI 10.1080/09637486.2019.1566445
   Salazar LA., 1998, Clin Chem, V45, P2016, DOI [10.1093/clinchem/45.11.2016, DOI 10.1093/CLINCHEM/45.11.2016]
   Segall-Correa A. M., 2009, Seguranca Alimentar e Nutricional, V16, P1
   Seifu CN, 2021, PUBLIC HEALTH NUTR, V24, P6390, DOI 10.1017/S1368980021000823
   Sichieri R., 2007, Epidemiologia Nutricional
   Steiger H, 2013, INT J EAT DISORDER, V46, P246, DOI 10.1002/eat.22113
   Tost J, 2003, BIOTECHNIQUES, V35, P152, DOI 10.2144/03351md02
   Tremblay AJ, 2004, CLIN BIOCHEM, V37, P785, DOI 10.1016/j.clinbiochem.2004.03.008
   Turner JD, 2005, J MOL ENDOCRINOL, V35, P283, DOI 10.1677/jme.1.01822
   Tyrka AR, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.112
   VALDEZ R, 1991, J CLIN EPIDEMIOL, V44, P955, DOI 10.1016/0895-4356(91)90059-I
   van der Knaap LJ, 2014, TRANSL PSYCHIAT, V4, DOI 10.1038/tp.2014.22
   Vangeel EB, 2018, J PSYCHOSOM RES, V104, P55, DOI 10.1016/j.jpsychores.2017.11.011
   Velasquez-Melendez G, 2017, J AM COLL NUTR, V36, P99, DOI 10.1080/07315724.2016.1191975
   Verfaillie Tom, 2010, Int J Cell Biol, V2010, P930509, DOI 10.1155/2010/930509
   Vialou V, 2013, ANNU REV PHARMACOL, V53, P59, DOI 10.1146/annurev-pharmtox-010611-134540
   Vukojevic V, 2014, J NEUROSCI, V34, P10274, DOI 10.1523/JNEUROSCI.1526-14.2014
   Wang YP, 2013, REV BRAS PSIQUIATR, V35, P416, DOI 10.1590/1516-4446-2012-1048
   WHO Consultation, 2000, WHO TECH REP SER, V894, P1
NR 82
TC 0
Z9 0
U1 1
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD APR 3
PY 2024
VL 11
AR 1168715
DI 10.3389/fnut.2024.1168715
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA NX9I5
UT WOS:001203866200001
PM 38633601
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Liu, JH
   Qian, YX
   Ma, QH
   Sun, HP
   Xu, Y
   Pan, CW
AF Liu, Jing-Hong
   Qian, Yu-Xi
   Ma, Qing-Hua
   Sun, Hong-Peng
   Xu, Yong
   Pan, Chen-Wei
TI Depressive symptoms and metabolic syndrome components among older
   Chinese adults
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Depressive symptoms; Metabolic syndrome components; Public health;
   Epidemiology
ID QUALITY-OF-LIFE; BLOOD-PRESSURE; SEX; PREVALENCE; ANXIETY; RISK;
   ASSOCIATION; SEVERITY; DISORDER; SAMPLES
AB Background Few studies examined associations between depressive symptoms and metabolic syndrome (MetS) among older Chinese adults. Considering that the prevalence of depressive symptoms is high in older Chinese adults, we aimed to examine associations of depressive symptoms with MetS and its components in older Chinese adults. Methods Data from a community-based cross-sectional study of 4579 Chinese adults aged 60 years or older were analyzed. Depressive symptoms were assessed using the nine-item Patient Health Questionnaire. The presence of MetS was defined based on the Adult Treatment Panel III criteria, which include obesity, reduced blood high-density lipoprotein, high blood pressure (BP), elevated fasting plasma glucose and hypertriglyceridemia. A participant was considered as having MetS if he or she met at least three of the above-mentioned criteria. Results In all participants, depressive symptoms were related to elevated fasting plasma glucose (>= 7.0 mmol/L) (adjusted odds ratio [OR] = 1.50, 95% confidence interval [CI] [1.00-2.20]) and diabetes (adjusted OR = 1.50, 95% CI [1.01-2.20]). The associations of depressive symptoms with MetS and its components were not significant among women. However, there was a negative association between depressive symptoms and elevated systolic BP (>= 130 mm Hg) (OR = 0.59, 95% CI [0.4-0.9]), and similar findings were observed after adjusting for lifestyle-related variables in men. Conclusions In older Chinese adults, depressive symptoms were negatively associated with elevated systolic BP in men while these findings were not found in women.
C1 [Liu, Jing-Hong; Qian, Yu-Xi; Sun, Hong-Peng; Xu, Yong; Pan, Chen-Wei] Soochow Univ, Coll Med, Sch Publ Hlth, 199 Ren Ai Rd, Suzhou 215123, Peoples R China.
   [Ma, Qing-Hua] 3rd Peoples Hosp Xiangcheng Dist, Suzhou, Peoples R China.
C3 Soochow University - China
RP Pan, CW (corresponding author), Soochow Univ, Coll Med, Sch Publ Hlth, 199 Ren Ai Rd, Suzhou 215123, Peoples R China.
EM pcwonly@gmail.com
RI Ma, Qinghua/KPA-8692-2024; Pan, Chen-Wei/L-7174-2019; Sun,
   Hongpeng/JUF-6741-2023
OI Pan, Chen-Wei/0000-0003-3362-4613
FU Science and Technology Bureau of Xiangcheng District in Suzhou, China
   [XJ201706]; Health Commission of Suzhou [GSWS2019090]
FX This study was supported by the Science and Technology Bureau of
   Xiangcheng District in Suzhou, China under Grant No. XJ201706 and the
   Health Commission of Suzhou under Grant No. GSWS2019090.
CR Badr H, 2017, AGING MENT HEALTH, V21, P975, DOI 10.1080/13607863.2016.1186153
   Barnes JN, 2017, EXP PHYSIOL, V102, P1385, DOI 10.1113/EP086531
   Block A, 2016, NORD J PSYCHIAT, V70, P611, DOI 10.1080/08039488.2016.1191535
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   DeBoer MD, 2015, J AM COLL CARDIOL, V66, P756, DOI 10.1016/j.jacc.2015.05.061
   Diniz BS, 2012, J PSYCHIATR RES, V46, P1081, DOI 10.1016/j.jpsychires.2012.04.028
   Forlani C, 2014, AM J GERIAT PSYCHIAT, V22, P370, DOI 10.1016/j.jagp.2012.08.015
   Gonçalves-Pereira M, 2019, J AFFECT DISORDERS, V246, P674, DOI 10.1016/j.jad.2018.12.067
   Graham E, 2017, INT J GERIATR PSYCH, V32, P1450, DOI 10.1002/gps.4634
   Gurka MJ, 2016, PSYCHONEUROENDOCRINO, V68, P82, DOI 10.1016/j.psyneuen.2016.02.030
   Hildrum B, 2009, ACTA PSYCHIAT SCAND, V120, P14, DOI 10.1111/j.1600-0447.2008.01315.x
   Hildrum B, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-601
   Joseph JJ, 2017, ANN NY ACAD SCI, V1391, P20, DOI 10.1111/nyas.13217
   Karl T, 2007, PEPTIDES, V28, P326, DOI 10.1016/j.peptides.2006.07.027
   Kloner RA, 2016, J AM COLL CARDIOL, V67, P545, DOI 10.1016/j.jacc.2015.12.005
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Kroenke K, 2010, GEN HOSP PSYCHIAT, V32, P345, DOI 10.1016/j.genhosppsych.2010.03.006
   Li D, 2014, ARCH GERONTOL GERIAT, V58, P1, DOI 10.1016/j.archger.2013.07.016
   Licht CMM, 2009, HYPERTENSION, V53, P631, DOI 10.1161/HYPERTENSIONAHA.108.126698
   Luppa M, 2012, J AFFECT DISORDERS, V136, P212, DOI 10.1016/j.jad.2010.11.033
   Marijnissen RM, 2013, J AFFECT DISORDERS, V151, P1138, DOI 10.1016/j.jad.2013.07.029
   Michalkiewicz M, 2003, HYPERTENSION, V41, P1056, DOI 10.1161/01.HYP.0000066623.64368.4E
   Niu K, 2008, HYPERTENS RES, V31, P409, DOI 10.1291/hypres.31.409
   Organization W.H., 2017, Depression and other common mental disorders: Global health estimates
   Pan CW, 2018, ARCH GERONTOL GERIAT, V76, P6, DOI 10.1016/j.archger.2018.01.008
   Pan CW, 2015, SCI REP-UK, V5, DOI 10.1038/srep17301
   Peng YF, 2017, ADV CLIN EXP MED, V26, P665, DOI 10.17219/acem/63023
   Rethorst CD, 2014, J CLIN PSYCHIAT, V75, pE1428, DOI 10.4088/JCP.14m09009
   Sabanayagam C, 2011, INVEST OPHTH VIS SCI, V52, P2397, DOI 10.1167/iovs.10-6373
   Scuteri A, 2009, AGING CLIN EXP RES, V21, P292
   Sekita A, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-862
   Shinn EH, 2001, AM J HYPERTENS, V14, P660, DOI 10.1016/S0895-7061(01)01304-8
   Sjöberg L, 2017, J AFFECT DISORDERS, V221, P123, DOI 10.1016/j.jad.2017.06.011
   Spitzer RL, 1999, JAMA-J AM MED ASSOC, V282, P1737, DOI 10.1001/jama.282.18.1737
   Steffens DC, 2002, STROKE, V33, P1636, DOI 10.1161/01.STR.0000018405.59799.D5
   Stunkard AJ, 2003, BIOL PSYCHIAT, V54, P330, DOI 10.1016/S0006-3223(03)00608-5
   Sutin AR, 2010, J AFFECT DISORDERS, V127, P241, DOI 10.1016/j.jad.2010.06.004
   Tikhonoff V, 2014, J HYPERTENS, V32, P1590, DOI 10.1097/HJH.0000000000000244
   Van der Kooy K, 2007, INT J GERIATR PSYCH, V22, P613, DOI 10.1002/gps.1723
   Viscogliosi G, 2013, INT J GERIATR PSYCH, V28, P242, DOI 10.1002/gps.3817
   Vogelzangs N, 2008, ARCH GEN PSYCHIAT, V65, P1386, DOI 10.1001/archpsyc.65.12.1386
   Wang HF, 2016, OPTOMETRY VISION SCI, V93, P1479, DOI 10.1097/OPX.0000000000000960
   Yu M, 2015, CAN J DIABETES, V39, P266, DOI 10.1016/j.jcjd.2014.11.006
NR 43
TC 15
Z9 16
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD FEB 18
PY 2020
VL 12
IS 1
AR 18
DI 10.1186/s13098-020-00526-2
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA KQ9HR
UT WOS:000517232300002
PM 32099584
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jatana, S
   Abbadi, A
   Ponti, AK
   West, GA
   Braga-Neto, MB
   Smith, JL
   Marino-Melendez, A
   Willard, B
   Nagy, LE
   de la Motte, C
AF Jatana, Samreen
   Abbadi, Amina
   Ponti, Andras K.
   West, Gail A.
   Braga-Neto, Manuel B.
   Smith, Jordyn L.
   Marino-Melendez, Armando
   Willard, Belinda
   Nagy, Laura E.
   de la Motte, Carol
TI Hyperglycemic environments directly compromise intestinal epithelial
   barrier function in an organoid model and hyaluronan (∼35 kDa) protects
   via a layilin dependent mechanism
SO MATRIX BIOLOGY
LA English
DT Article
DE Hyperglycemia; Metabolic syndrome; Hyaluronan; Intestinal barrier;
   Organoids; Apoptosis; Layilin
ID IN-VITRO; HIGH GLUCOSE; STEM-CELLS; ZO-1; INFLAMMATION
AB Background: Metabolic syndrome and diabetes in obese individuals are strong risk factors for development of inflammatory bowel disease (IBD) and colorectal cancer. The pathogenic mechanisms of low-grade metabolic inflammation, including chronic hyperglycemic stress, in disrupting gut homeostasis are poorly understood. In this study, we sought to understand the impact of a hyperglycemic environment on intestinal barrier integrity and the protective effects of small molecular weight (35 kDa) hyaluronan on epithelial barrier function.
   Methods: Intestinal organoids derived from mouse colon were grown in normal glucose media (5 mM) or high glucose media (25 mM) to study the impact of hyperglycemic stress on the intestinal barrier. Additionally, organoids were pretreated with 35 kDa hyaluronan (HA35) to investigate the effect of hyaluronan on epithelial barrier under high glucose stress. Immunoblotting as well as confocal imaging was used to understand changes in barrier proteins, quantitative as well as spatial distribution, respectively. Alterations in barrier function were measured using trans-epithelial electrical resistance and fluorescein isothiocyanate flux assays. Untargeted proteomics analysis was performed to elucidate mechanisms by which HA35 exerts a protective effect on the barrier. Intestinal organoids derived from receptor knockout mice specific to various HA receptors were utilized to understand the role of HA receptors in barrier protection under high glucose conditions.
   Results: We found that high glucose stress decreased the protein expression as well as spatial distribution of two key barrier proteins, zona occludens-1 (ZO-1) and occludin. HA35 prevented the degradation or loss of ZO-1 and maintained the spatial distribution of both ZO-1 and occludin under hyperglycemic stress. Functionally, we also observed a protective effect of HA35 on the epithelial barrier under high glucose conditions. We found that HA receptor, layilin, was involved in preventing barrier protein loss (ZO-1) as well as maintaining spatial distribution of ZO-1 and occludin. Additionally, proteomics analysis showed that cell death and survival was the primary pathway upregulated in organoids treated with HA35 under high glucose stress. We found that XIAP associated factor 1 (Xaf1) was modulated by HA35 thereby regulating apoptotic cell death in the intestinal organoid system. Finally, we observed that spatial organization of both focal adhesion kinase (FAK) as well as Factin was mediated by HA35 via layilin.
   Conclusion: Our results highlight the impact of hyperglycemic stress on the intestinal barrier function. This is of clinical relevance, as impaired barrier function has been observed in individuals with metabolic syndrome. Additionally, we demonstrate barrier protective effects of HA35 through its receptor layilin and modulation of cellular apoptosis under high glucose stress.
C1 [Jatana, Samreen; Abbadi, Amina; West, Gail A.; Smith, Jordyn L.; Marino-Melendez, Armando; Nagy, Laura E.; de la Motte, Carol] Cleveland Clin, Lerner Res Inst, Dept Inflammat & Immun, Cleveland, OH USA.
   [Ponti, Andras K.] Cleveland Clin, Lerner Res Inst, Dept Cardiovasc & Metab Sci, Cleveland, OH USA.
   [Braga-Neto, Manuel B.] Cleveland Clin Fdn, Digest Dis & Surg Inst, Dept Gastroenterol Hepatol & Nutr, Cleveland, OH USA.
   [Willard, Belinda] Cleveland Clin, Lerner Res Inst, Proteom & Metab Core, Cleveland, OH USA.
   [Nagy, Laura E.] Cleveland Clin, Northern Ohio Alcohol Ctr, Dept Inflammat & Immun, Cleveland, OH USA.
   [Nagy, Laura E.; de la Motte, Carol] Cleveland Clin, Dept Gastroenterol & Hepatol, Cleveland, OH USA.
   [Nagy, Laura E.] Case Western Reserve Univ, Cleveland Clin, Lerner Coll Med, Dept Mol Med, Cleveland, OH USA.
C3 Cleveland Clinic Foundation; Cleveland Clinic Foundation; Cleveland
   Clinic Foundation; Cleveland Clinic Foundation; Cleveland Clinic
   Foundation; Cleveland Clinic Foundation; University System of Ohio; Case
   Western Reserve University; Cleveland Clinic Foundation
RP Jatana, S; de la Motte, C (corresponding author), Cleveland Clin, Lerner Res Inst, Cleveland, OH 44195 USA.
EM jatanas@ccf.org; delamoc@ccf.org
RI Nagarajan, Arun/HIZ-8452-2022
OI Jatana, Samreen/0000-0001-8255-7045; Braga Neto, Manuel
   B/0000-0001-8451-1753
FU National Institutes of Health (NIH) [R01AA023764]; Department of Defense
   (DOD) [PR190724/W81XWH2010235]; Crohn's and Colitis Foundation Research
   Fellowship Award [662997]; NIH Shared Instrumentation Grant
   [1S10OD019972-01, S10 OD030398]
FX This work was supported by National Institutes of Health (NIH) grant
   R01AA023764 and Department of Defense (DOD) grant PR190724/W81XWH2010235
   to LEN and CdlM. This study was also funded by the Crohn's and Colitis
   Foundation Research Fellowship Award (Award# 662997) to SJ. This work
   utilized the Leica SP8 confocal microscope that was purchased with from
   the NIH Shared Instrumentation Grant 1S10OD019972-01. The Bruker timsTof
   Pro2 instrument used for pro-teomics analysis was purchased via an NIH
   Shared Instrument Grant, S10 OD030398.
CR Aliluev A, 2021, NAT METAB, V3, P1202, DOI 10.1038/s42255-021-00458-9
   Balda MS, 2003, J CELL BIOL, V160, P423, DOI 10.1083/jcb.200210020
   Bass MD, 1999, BIOCHEM J, V341, P257, DOI 10.1042/0264-6021:3410257
   Bellar A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11051135
   Bellos DA, 2019, ALCOHOL CLIN EXP RES, V43, P1848, DOI 10.1111/acer.14140
   Bhat AA, 2019, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01942
   Calderwood DA, 2013, NAT REV MOL CELL BIO, V14, P503, DOI 10.1038/nrm3624
   Carvalho AM, 2023, ADV HEALTHC MATER, V12, DOI 10.1002/adhm.202202118
   Chen M, 2023, CELL REP, V42, DOI 10.1016/j.celrep.2023.112690
   Co JY, 2021, NAT PROTOC, V16, P5171, DOI 10.1038/s41596-021-00607-0
   Cong X, 2020, CELL SIGNAL, V66, DOI 10.1016/j.cellsig.2019.109485
   De Filippis A, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21144929
   de la Motte CA, 2011, AM J PHYSIOL-GASTR L, V301, pG945, DOI 10.1152/ajpgi.00063.2011
   Di Tommaso N, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph182312836
   Dubois N, 2023, BIOCHEM PHARMACOL, V216, DOI 10.1016/j.bcp.2023.115765
   Glasgow JE, 2022, CELL CHEM BIOL, V29, P597, DOI 10.1016/j.chembiol.2022.01.003
   González-Mariscal L, 2008, BBA-BIOMEMBRANES, V1778, P729, DOI 10.1016/j.bbamem.2007.08.018
   Gunasekaran A, 2020, PEDIATR RES, V87, P1177, DOI 10.1038/s41390-019-0563-9
   Hill DR, 2013, J BIOL CHEM, V288, P29090, DOI 10.1074/jbc.M113.468629
   Hotamisligil GS, 2017, NATURE, V542, P177, DOI 10.1038/nature21363
   Hyun CK, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22179139
   Jeong SI, 2018, CELL DEATH DIS, V9, DOI 10.1038/s41419-018-0867-4
   Kadry YA, 2020, BBA-BIOMEMBRANES, V1862, DOI 10.1016/j.bbamem.2020.183206
   Kang EA, 2019, J CLIN MED, V8, DOI 10.3390/jcm8030343
   Kessler SP, 2018, J HISTOCHEM CYTOCHEM, V66, P273, DOI 10.1369/0022155417746775
   Kim Y, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.00569
   Kim Y, 2018, MATRIX BIOL, V66, P93, DOI 10.1016/j.matbio.2017.09.003
   Kim Y, 2017, MATRIX BIOL, V62, P28, DOI 10.1016/j.matbio.2016.11.001
   Kuo WT, 2022, ANN NY ACAD SCI, V1514, P21, DOI 10.1111/nyas.14798
   Kuo WT, 2021, GASTROENTEROLOGY, V161, P1924, DOI 10.1053/j.gastro.2021.08.047
   Kuo WT, 2019, GASTROENTEROLOGY, V157, P1323, DOI 10.1053/j.gastro.2019.07.058
   Lawler T, 2023, JAMA NETW OPEN, V6, DOI 10.1001/jamanetworkopen.2023.43333
   Lechuga S, 2023, FRONT IMMUNOL, V14, DOI 10.3389/fimmu.2023.1108289
   Li ML, 2017, EXP THER MED, V14, P1732, DOI 10.3892/etm.2017.4651
   Lin CY, 2015, WORLD J GASTROENTERO, V21, P2047, DOI 10.3748/wjg.v21.i7.2047
   Ma BW, 2023, BMC CANCER, V23, DOI 10.1186/s12885-023-11077-w
   Ma YJ, 2013, BBA-MOL BASIS DIS, V1832, P151, DOI 10.1016/j.bbadis.2012.10.006
   Manning BD, 2017, CELL, V169, P381, DOI 10.1016/j.cell.2017.04.001
   Miyoshi H, 2013, NAT PROTOC, V8, P2471, DOI 10.1038/nprot.2013.153
   Owen KA, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023123
   Peng Y, 2022, FRONT ONCOL, V12, DOI 10.3389/fonc.2022.819128
   Petrey AC, 2014, FRONT IMMUNOL, V5, DOI 10.3389/fimmu.2014.00101
   Phelps NH, 2024, LANCET, V403, P1027, DOI 10.1016/S0140-6736(23)02750-2
   Priest C, 2019, NAT METAB, V1, P1177, DOI 10.1038/s42255-019-0145-5
   Ray S, 2023, MATRIX BIOL, V115, P71, DOI 10.1016/j.matbio.2022.11.008
   Riedel S, 2022, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.833544
   Sang MM, 2022, WORLD J DIABETES, V13, P126, DOI 10.4239/wjd.v13.i2.126
   Sato T, 2009, NATURE, V459, P262, DOI 10.1038/nature07935
   Schleh MW, 2023, SCI TRANSL MED, V15, DOI 10.1126/scitranslmed.adf9382
   Shen LJ, 2019, BMC ENDOCR DISORD, V19, DOI 10.1186/s12902-019-0354-7
   Singh R, 2019, NAT REV MOL CELL BIO, V20, P175, DOI 10.1038/s41580-018-0089-8
   Soler AP, 1999, CARCINOGENESIS, V20, P1425, DOI 10.1093/carcin/20.8.1425
   Thaiss CA, 2018, SCIENCE, V359, P1376, DOI 10.1126/science.aar3318
   VanDussen KL, 2019, STEM CELL RES, V37, DOI 10.1016/j.scr.2019.101430
   Vulcan A, 2017, BMC CANCER, V17, DOI 10.1186/s12885-017-3874-4
   Wang J, 2009, CARCINOGENESIS, V30, P1507, DOI 10.1093/carcin/bgp155
   Wang YF, 2022, DIABETOL METAB SYNDR, V14, DOI 10.1186/s13098-022-00943-5
   Xu JL, 2012, STEM CELLS, V30, P1885, DOI 10.1002/stem.1172
   Xu JM, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2016-011430
   Yuan JH, 2021, J DIABETES COMPLICAT, V35, DOI 10.1016/j.jdiacomp.2020.107766
   Zhang XF, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.742584
   Zihni C, 2016, NAT REV MOL CELL BIO, V17, P564, DOI 10.1038/nrm.2016.80
NR 62
TC 3
Z9 3
U1 2
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0945-053X
EI 1569-1802
J9 MATRIX BIOL
JI Matrix Biol.
PD NOV
PY 2024
VL 133
BP 116
EP 133
DI 10.1016/j.matbio.2024.08.007
EA SEP 2024
PG 18
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA Q7M8S
UT WOS:001386482200001
PM 39187208
OA hybrid
DA 2025-06-11
ER

PT J
AU Puustinen, PJ
   Koponen, H
   Kautiainen, H
   Mäntyselkä, P
   Vanhala, M
AF Puustinen, Pekka Johannes
   Koponen, Hannu
   Kautiainen, Hannu
   Mantyselka, Pekka
   Vanhala, Mauno
TI Psychological Distress Predicts the Development of the Metabolic
   Syndrome: A Prospective Population-Based Study
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE psychological distress; General Health Questionnaire; metabolic
   syndrome; health behaviors; C-reactive protein; inflammation
ID STRESSFUL LIFE EVENTS; C-REACTIVE PROTEIN; DEPRESSIVE SYMPTOMS;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; YOUNG-ADULTS; HEALTH; RISK;
   ANXIETY; INFLAMMATION
AB Objective: To examine prospectively the association of psychological distress with the development of the metabolic syndrome (MetS) and the potential influence of demographic characteristics, health behaviors, and inflammation in this association. Methods: A total of 466 (n = 185 males; 281 females) subjects, aged 36 to 56 years, and free of MetS at baseline, participated in a population-based study from 1997 to 1998 and again from 2004 to 2005. Mean observation time was 6.4 years. Various clinical, biochemical, and behavioral factors were measured at baseline, including assessment of psychological distress using the 12-item General Health Questionnaire. The development of MetS was measured at follow-up based on National Cholesterol Education Program criteria. Results: Subjects with high psychological distress at baseline (General Health Questionnaire scores, 4-12) were more than twice as likely to develop MetS than those with low psychological distress (odds ratio, 2.18; 95% confidence interval, 1.30-3.64). Adjustments for 1) age, gender, and sociodemographic variables; 2) health behaviors (smoking, alcohol use, and leisure time physical activity); and 3) C-reactive protein in the analysis diminished the odds of developing MetS in the distressed group (odds ratio, 1.87; 95% confidence interval, 1.83 and 1.81, respectively); however, the association remained statistically significant (p=.025-.038). Conclusions: Psychological distress at baseline increases the risk of developing MetS during follow-up. This association remained robust after adjusting for age, gender, sociodemographic variables, baseline health behaviors, and C-reactive protein. These prospective findings are evidence of a significant association between psychological distress and the development of MetS.
C1 [Puustinen, Pekka Johannes] Ctr Social & Hlth Serv, Kuopio 70101, Finland.
   [Mantyselka, Pekka] Univ Eastern Finland, Sch Med, Unit Primary Hlth Care, Kuopio, Finland.
   [Koponen, Hannu; Kautiainen, Hannu] Univ Eastern Finland, Dept Psychiat, Kuopio, Finland.
   Kuopio Univ Hosp, Unit Family Practice, SF-70210 Kuopio, Finland.
   [Koponen, Hannu; Kautiainen, Hannu; Vanhala, Mauno] Cent Hosp Middle Finland, Unit Family Practice, Jyvaskyla, Finland.
   ORTON, Rehabil Unit, Helsinki, Finland.
C3 University of Eastern Finland; University of Eastern Finland; Kuopio
   University Hospital; University of Eastern Finland; University of
   Eastern Finland Hospital; Central Finland Central Hospital
RP Puustinen, PJ (corresponding author), Ctr Social & Hlth Serv, PL 227, Kuopio 70101, Finland.
EM puustinenpekka@hotmail.com
CR ADLER N, 1994, ANNU REV PSYCHOL, V45, P229, DOI 10.1146/annurev.psych.45.1.229
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   Brborovic O, 2009, COLLEGIUM ANTROPOL, V33, P93
   Capuron L, 2008, BIOL PSYCHIAT, V64, P896, DOI 10.1016/j.biopsych.2008.05.019
   Carroll D, 2009, BIOL PSYCHIAT, V66, P91, DOI 10.1016/j.biopsych.2009.02.020
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cohen BE, 2010, PSYCHIAT RES, V175, P133, DOI 10.1016/j.psychres.2009.02.004
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   Elovainio M, 2009, PSYCHOSOM MED, V71, P423, DOI 10.1097/PSY.0b013e31819e333a
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   Ford ES, 2005, DIABETES CARE, V28, P2745, DOI 10.2337/diacare.28.11.2745
   Goldbacher EM, 2007, ANN BEHAV MED, V34, P240, DOI 10.1007/BF02874549
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Goldberg D.P., 1972, DETECTION PSYCHIAT I, V21
   Goldberg DP, 1997, PSYCHOL MED, V27, P191, DOI 10.1017/S0033291796004242
   Grundy SM, 2006, DIABETES CARE, V29, P1689, DOI 10.2337/dc05-2307
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hamer M, 2008, J AM COLL CARDIOL, V52, P2156, DOI 10.1016/j.jacc.2008.08.057
   Han TS, 2002, DIABETES CARE, V25, P2016, DOI 10.2337/diacare.25.11.2016
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Hildrum B, 2009, ACTA PSYCHIAT SCAND, V120, P14, DOI 10.1111/j.1600-0447.2008.01315.x
   Holi MM, 2003, NORD J PSYCHIAT, V57, P233, DOI 10.1080/08039480310001418
   Hotopf M, 1998, SOC PSYCH PSYCH EPID, V33, P27
   KAHN RA, 2006, DIABETES CARE, V29, P163
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Laudisio A, 2009, J GERIATR PSYCH NEUR, V22, P215, DOI 10.1177/0891988709335793
   Lipsanen T, 2004, PSYCHOPATHOLOGY, V37, P200, DOI 10.1159/000080132
   Miettola J, 2008, SCAND J PRIM HEALTH, V26, P203, DOI 10.1080/02813430802117624
   Muhtz C, 2009, PSYCHONEUROENDOCRINO, V34, P1004, DOI 10.1016/j.psyneuen.2009.01.016
   Nagano M, 2004, METAB SYNDR RELAT D, V2, P172, DOI 10.1089/met.2004.2.172
   Pulkki-Råback L, 2009, HEALTH PSYCHOL, V28, P108, DOI 10.1037/a0012646
   Pyykkönen AJ, 2010, DIABETES CARE, V33, P378, DOI 10.2337/dc09-1027
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Räikkönen K, 2007, DIABETES CARE, V30, P872, DOI 10.2337/dc06-1857
   Rosolova H, 2009, Vnitr Lek, V55, P650
   Saltevo J, 2007, MEDIAT INFLAMM, V2007, DOI 10.1155/2007/93573
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Suarez EC, 2006, BRAIN BEHAV IMMUN, V20, P331, DOI 10.1016/j.bbi.2005.09.005
   Takeuchi T, 2009, DIABETES METAB, V35, P32, DOI 10.1016/j.diabet.2008.06.006
   Toker S, 2008, DEPRESS ANXIETY, V25, P661, DOI 10.1002/da.20379
   Vanhala M, 2009, ACTA PSYCHIAT SCAND, V119, P137, DOI 10.1111/j.1600-0447.2008.01283.x
   Viinamäki H, 2009, ACTA PSYCHIAT SCAND, V120, P23, DOI 10.1111/j.1600-0447.2008.01333.x
   Vitaliano PP, 2002, PSYCHOSOM MED, V64, P418, DOI 10.1097/00006842-200205000-00006
   Vogelzangs N, 2007, J GERONTOL A-BIOL, V62, P563, DOI 10.1093/gerona/62.5.563
   Vogelzangs N, 2007, PSYCHONEUROENDOCRINO, V32, P151, DOI 10.1016/j.psyneuen.2006.11.009
   Williams P., 1988, A Users Guide to the General Health Questionnaire
   Zambon A, 2005, ALIMENT PHARM THER, V22, P20, DOI 10.1111/j.1365-2036.2005.02589.x
NR 51
TC 56
Z9 65
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD FEB-MAR
PY 2011
VL 73
IS 2
BP 158
EP 165
DI 10.1097/PSY.0b013e3182037315
PG 8
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 725QY
UT WOS:000287662200006
PM 21148808
DA 2025-06-11
ER

PT J
AU McGrath-Morrow, SA
   Collaco, JM
   Crawford, TO
   Carson, KA
   Lefton-Greif, MA
   Zeitlin, P
   Lederman, HM
AF McGrath-Morrow, Sharon A.
   Collaco, J. Michael
   Crawford, Thomas O.
   Carson, Kathryn A.
   Lefton-Greif, Maureen A.
   Zeitlin, Pamela
   Lederman, Howard M.
TI Elevated Serum IL-8 Levels in Ataxia Telangiectasia
SO JOURNAL OF PEDIATRICS
LA English
DT Article
ID METABOLIC SYNDROME; ATM; STRESS; GENE
AB Serum interleukin (IL)-8 levels were measured in 50 patients with ataxia telangiectasia (A-T) and 22 without A-T. In a cross-sectional study, the geometric mean of IL-8 level was significantly higher in the patients with A-T (P <. 0001). Elevated serum IL-8 levels in patients with A-T suggest that systemic inflammation may contribute to the disease phenotype. (J Pediatr 2010; 156: 682-4)
C1 [McGrath-Morrow, Sharon A.] Johns Hopkins Med Inst, Dept Pediat, Div Pediat Pulmonol, Baltimore, MD 21287 USA.
   [Lederman, Howard M.] Johns Hopkins Med Inst, Div Pediat Allergy & Immunol, Baltimore, MD 21287 USA.
   [Crawford, Thomas O.] Johns Hopkins Med Inst, Dept Neurol, Baltimore, MD 21287 USA.
   [Carson, Kathryn A.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
C3 Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins
   University; Johns Hopkins Medicine; Johns Hopkins University; Johns
   Hopkins Medicine; Johns Hopkins University; Johns Hopkins Bloomberg
   School of Public Health
RP McGrath-Morrow, SA (corresponding author), Johns Hopkins Med Inst, Dept Pediat, Div Pediat Pulmonol, Suite 3029,200 N Wolfe St, Baltimore, MD 21287 USA.
EM smorrow@jhmi.edu
RI McGrath-Morrow, Sharon/JMC-0464-2023; Crawford, Thomas/E-6307-2012
OI Zeitlin, Pamela/0000-0002-2719-1834
FU National Center for Research Resources, a component of the National
   Institutes of Health (NIH); NIH Roadmap for Medical Research [UL1RR
   025005]; Johns Hopkins Hospital Pediatric Clinical Research Center [UL1
   RR 025005]
FX Supported by the AT Children's Project, National Center for Research
   Resources, a component of the National Institutes of Health (NIH); NIH
   Roadmap for Medical Research Grant UL1RR 025005 (to K. C.); and Johns
   Hopkins Hospital Pediatric Clinical Research Center Grant UL1 RR 025005
   (to S. M.- M., T. C., P. Z., and H. L.). The authors declare no
   conflicts of interest.
CR Barzilai A, 2002, DNA REPAIR, V1, P3, DOI 10.1016/S1568-7864(01)00007-6
   Cabana MD, 1998, PEDIATRICS, V102, P98, DOI 10.1542/peds.102.1.98
   Giovannelli A, 1998, J NEUROIMMUNOL, V92, P122, DOI 10.1016/S0165-5728(98)00192-1
   MATSUMOTO T, 1993, CLIN EXP IMMUNOL, V93, P149
   McKinnon PJ, 2004, EMBO REP, V5, P772, DOI 10.1038/sj.embor.7400210
   Niwa Y, 2000, ARCH DERMATOL RES, V292, P391, DOI 10.1007/s004030000148
   SAVITSKY K, 1995, SCIENCE, V268, P1749, DOI 10.1126/science.7792600
   Schneider JG, 2006, CELL METAB, V4, P377, DOI 10.1016/j.cmet.2006.10.002
   Shoelson SE, 2006, CELL METAB, V4, P337, DOI 10.1016/j.cmet.2006.10.009
   THEATRE E, 2009, AM J RESP CELL MOL B
   Zhang J, 2008, AM J CLIN PATHOL, V129, P526, DOI 10.1309/W01Y0B808EMEH12L
NR 11
TC 38
Z9 40
U1 0
U2 1
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
J9 J PEDIATR-US
JI J. Pediatr.
PD APR
PY 2010
VL 156
IS 4
BP 682
EP U213
DI 10.1016/j.jpeds.2009.12.007
PG 4
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 572CR
UT WOS:000275805000032
PM 20171651
DA 2025-06-11
ER

PT J
AU Perrone, MG
   Santandrea, E
   Bleve, L
   Vitale, P
   Colabufo, NA
   Jockers, R
   Milazzo, FM
   Sciarroni, AF
   Scilimati, A
AF Perrone, Maria Grazia
   Santandrea, Ernesto
   Bleve, Laura
   Vitale, Paola
   Colabufo, Nicola Antonio
   Jockers, Ralf
   Milazzo, Ferdinando Maria
   Sciarroni, Anna Floriana
   Scilimati, Antonio
TI Stereospecific synthesis and bio-activity of novel
   β3-adrenoceptor agonists and inverse agonists
SO BIOORGANIC & MEDICINAL CHEMISTRY
LA English
DT Article
DE agonist; inverse agonist; beta(3)-adrenoceptor; (alpha S : beta S)- and
   (alpha S : beta R)-2-{4-[2-(2-hydroxy-2
   phenylethylamino)ethyl]phenoxy}propanoic acid; obesity; type 2 diabetes;
   heart failure; cachexia; metabolic syndrome; overactive bladder; preterm
   labour; anxiety and depressive disorders; DELFIA
ID BETA(3) ADRENERGIC-RECEPTOR; CARBOXYL-PROMOTED ENHANCEMENT; FREQUENT
   URINATION; PHARMACOLOGICAL CHARACTERIZATION; PART 1; POTENT; DISCOVERY;
   IDENTIFICATION; ADRENOCEPTOR; DERIVATIVES
AB Since it is widely distributed into the body, beta(3)-adrenoceptor is becoming an attractive target for the treatment of several pathologies such as obesity, type 2 diabetes, metabolic syndrome, cachexia, overactive bladder, ulcero-inflammatory disorder of the gut, preterm labour, anxiety and depressive disorders, and heart failure. New compounds belonging to the class of arylethanolamines bearing one or two stereogenic centres were prepared in good yields as racemates and optically active forms. They were, then, evaluated for their intrinsic activity towards beta(3)-adrenoceptor and their affinity for beta(1)- and beta(2)-adrenergic receptors. Stereochemical features were found to play a crucial role in determining the behaviour of such compounds. In particular, alpha-racemic, (alpha R)- and (alpha S)2-14-[2-(2-hydroxy-2-phenylethylamino)ethyl]phenoxy)-2- methylpropanoic acid, (alpha-rac, beta-rac)-, (alpha R, beta S)- and (alpha R, beta R)- 2- 4-[2-(2-hydroxy-2-phenylethylamino)ethyl]phenoxylpropanoic acid were found to be endowed with beta(3)-adrenoceptor agonistic activity. Whereas, (alpha S, beta S)- and (alpha S, beta R)-2-14-[2-(2-hydroxy-2-phenylethylamino)ethyl]phenoxy propanoic acid behaved as beta(3)-adrenoceptor inverse agonists. Such compounds showed no affinity for beta(1)- and beta(2)-adrenergic receptor, respectively. Thus, resulting highly selective beta(3)-adrenoceptor ligands. (C) 2007 Elsevier Ltd. All rights reserved.
C1 [Perrone, Maria Grazia; Santandrea, Ernesto; Bleve, Laura; Vitale, Paola; Colabufo, Nicola Antonio; Scilimati, Antonio] Univ Bari, Dept Farmacochim, I-70125 Bari, Italy.
   [Jockers, Ralf] Univ Paris, CNRS 8104, Inst Cochin Inserm U567, F-75014 Paris, France.
   [Milazzo, Ferdinando Maria; Sciarroni, Anna Floriana] Sigma Tau Pharmaceut Co, Dipartimento Endocrinol & Metabolismo, I-00040 Pomezia, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Centre National de la
   Recherche Scientifique (CNRS); Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Paris Cite; Leadiant Biosciences
RP Scilimati, A (corresponding author), Univ Bari, Dept Farmacochim, Via E Orabona 4, I-70125 Bari, Italy.
EM ascilimati@farmchim.uniba.it
RI Jockers, Ralf/Q-2100-2019; vitale, paola/A-3370-2014
OI vitale, paola/0000-0001-8132-2893; Scilimati,
   Antonio/0000-0003-2740-6425; Perrone, Maria Grazia/0000-0003-4195-5228
CR ARCH JRS, 1989, P NUTR SOC, V48, P215, DOI 10.1079/PNS19890032
   Baker JG, 2003, MOL PHARMACOL, V64, P1357, DOI 10.1124/mol.64.6.1357
   Baker JG, 2005, MOL PHARMACOL, V68, P1645, DOI 10.1124/mol.105.015461
   Berglund P, 1999, TETRAHEDRON-ASYMMETR, V10, P4191, DOI 10.1016/S0957-4166(99)00438-3
   Brockunier LL, 2001, BIOORG MED CHEM LETT, V11, P379, DOI 10.1016/S0960-894X(00)00669-7
   Candelore MR, 1999, J PHARMACOL EXP THER, V290, P649
   Costa T, 2005, TRENDS PHARMACOL SCI, V26, P618, DOI 10.1016/j.tips.2005.10.009
   Croci T, 2007, J PHARMACOL EXP THER, V321, P1118, DOI 10.1124/jpet.106.119123
   Dallanoce C, 2007, BIOORGAN MED CHEM, V15, P2533, DOI 10.1016/j.bmc.2007.01.056
   Dow RL, 2004, BIOORG MED CHEM LETT, V14, P3235, DOI 10.1016/j.bmcl.2004.03.089
   EMORINE LJ, 1989, SCIENCE, V245, P1118, DOI 10.1126/science.2570461
   Fisher LG, 1996, BIOORG MED CHEM LETT, V6, P2253, DOI 10.1016/0960-894X(96)00417-9
   Gabriel D, 2003, ASSAY DRUG DEV TECHN, V1, P291, DOI 10.1089/15406580360545107
   Gavai AV, 2001, BIOORG MED CHEM LETT, V11, P3041, DOI 10.1016/S0960-894X(01)00629-1
   *GRAPHPAD SOFTW IN, GRAPHPAD PRISM SOFTW
   Harada H, 2003, BIOORG MED CHEM LETT, V13, P1301, DOI 10.1016/S0960-894X(03)00073-8
   Hieble JP, 2007, CURR TOP MED CHEM, V7, P207, DOI 10.2174/156802607779318208
   Kashaw SK, 2003, BIOORG MED CHEM LETT, V13, P2481, DOI 10.1016/S0960-894X(03)00491-8
   Kaumann AJ, 1996, BRIT J PHARMACOL, V118, P2085, DOI 10.1111/j.1476-5381.1996.tb15648.x
   LANDS AM, 1967, NATURE, V214, P597, DOI 10.1038/214597a0
   Lohse MJ, 2003, INT CONGR SER, V1249, P55, DOI 10.1016/S0531-5131(03)00678-2
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   Maack K, 2001, BRIT J PHARMACOL, V132, P1817, DOI 10.1038/sj.bjp.0703992
   Manara L, 1996, BRIT J PHARMACOL, V117, P435, DOI 10.1111/j.1476-5381.1996.tb15209.x
   Mizuno K, 2005, BIOORGAN MED CHEM, V13, P855, DOI 10.1016/j.bmc.2004.10.032
   Mizuno K, 2004, BIOORG MED CHEM LETT, V14, P5959, DOI 10.1016/j.bmcl.2004.10.035
   Nakajima Y, 2005, BIOORG MED CHEM LETT, V15, P251, DOI 10.1016/j.bmcl.2004.11.001
   Nandakumar K, 2005, PHARMACOLOGY, V74, P1, DOI 10.1159/000082861
   Otera J, 1997, TETRAHEDRON, V53, P13633, DOI 10.1016/S0040-4020(97)00900-9
   Perrone MG, 2006, BIOORGAN MED CHEM, V14, P1207, DOI 10.1016/j.bmc.2005.09.046
   Perrone MG, 2005, EUR J MED CHEM, V40, P143, DOI 10.1016/j.ejmech.2004.09.018
   Pott C, 2006, PHARMAZIE, V61, P255
   Rozec B, 2006, PHARMACOL THERAPEUT, V111, P652, DOI 10.1016/j.pharmthera.2005.12.002
   Sawa M, 2006, CURR MED CHEM, V13, P25, DOI 10.2174/092986706775198015
   SCILIMATI A, 2006, Patent No. 2006000820
   Sher PM, 1997, MED CHEM RES, V7, P109
   Sher PM, 1997, BIOORG MED CHEM LETT, V7, P1583, DOI 10.1016/S0960-894X(97)00266-7
   Shih TL, 1999, BIOORG MED CHEM LETT, V9, P1251, DOI 10.1016/S0960-894X(99)00182-1
   Soudijn W, 2005, MED RES REV, V25, P398, DOI 10.1002/med.20031
   Steffan RJ, 2002, BIOORG MED CHEM LETT, V12, P2957, DOI 10.1016/S0960-894X(02)00607-8
   STEMMELIN J, 2007, NEUROPSYCHOPHARMACOL, V1, P1
   Strange PG, 2002, TRENDS PHARMACOL SCI, V23, P89, DOI 10.1016/S0165-6147(02)01993-4
   Strosberg AD, 1997, TRENDS PHARMACOL SCI, V18, P52
   Strosberg AD, 1996, TRENDS PHARMACOL SCI, V17, P373, DOI 10.1016/S0165-6147(96)80011-3
   Strosberg AD, 2000, B3 ADRENORECEPTOR, P1
   Tanaka N, 2003, J MED CHEM, V46, P105, DOI 10.1021/jm020177z
   Tanaka N, 2001, BIOORGAN MED CHEM, V9, P3265, DOI 10.1016/S0968-0896(01)00240-1
   Tanaka N, 2001, J MED CHEM, V44, P1436, DOI 10.1021/jm000455z
   TATE KM, 1991, EUR J BIOCHEM, V196, P357, DOI 10.1111/j.1432-1033.1991.tb15824.x
   Tisdale Michael J, 2003, J Support Oncol, V1, P159
   Uehling DE, 2006, J MED CHEM, V49, P2758, DOI 10.1021/jm0509445
   Uehling DE, 2002, J MED CHEM, V45, P567, DOI 10.1021/jm0101500
   Weber AE, 1998, BIOORG MED CHEM LETT, V8, P1101, DOI 10.1016/S0960-894X(98)00169-3
NR 53
TC 21
Z9 23
U1 0
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0968-0896
EI 1464-3391
J9 BIOORGAN MED CHEM
JI Bioorg. Med. Chem.
PD MAR 1
PY 2008
VL 16
IS 5
BP 2473
EP 2488
DI 10.1016/j.bmc.2007.11.060
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry,
   Organic
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
GA 288RB
UT WOS:000255002400028
PM 18083578
DA 2025-06-11
ER

PT J
AU Li, AH
   Lee, BC
   Chen, KC
   Weng, CS
   Chu, SH
AF Li, Ai-Hsien
   Lee, Bai-Chin
   Chen, Kuo-Chin
   Weng, Ching-Sung
   Chu, Shu-Hsun
TI Brachial Artery Flow-Mediated Vasodilation in Patients With Cardiac
   Syndrome X
SO ANGIOLOGY
LA English
DT Article
DE cardiac syndrome X; endothelium; flow-mediated vasodilatation;
   endothelin-1
ID NORMAL CORONARY ARTERIOGRAMS; ENDOTHELIAL DYSFUNCTION; CHEST-PAIN;
   MYOCARDIAL-PERFUSION; ANGINA-PECTORIS; DISEASE; DILATION; ANGIOGRAMS;
   THICKNESS
AB Cardiac syndrome X (CSX) differs from coronary artery disease (CAD) and is characterized by angina, positive stress test, and patent coronary arteries. The probable mechanism is a microvascular disorder associated with endothelial dysfunction. In this study, brachial artery flow-mediated vasodilation was used as well as the endothelin-1 assay to assess endothelial function in patients with cardiac syndrome X (CSX), coronary artery disease (CAD), and healthy controls. All subjects underwent a 2-step brachial artery flow-related vasodilatation test. Serum endothelin-1, one of the most potent constricting factors, was measured for all participants. Patients with CSX had a lower brachial artery dilation ratio than controls but higher than that of CAD patients. Control subjects and CSX patients had higher endothelin-1 levels than CAD patients. CSX patients were found to have worse endothelial function than health), volunteers, but patients with CAD had even worse endothelium function than CSX patients.
C1 [Li, Ai-Hsien; Weng, Ching-Sung] Chung Yuan Christian Univ, Dept Biomed Engn, Chungli, Taiwan.
   [Li, Ai-Hsien; Lee, Bai-Chin] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan.
   [Li, Ai-Hsien; Chen, Kuo-Chin; Chu, Shu-Hsun] Far Eastern Mem Hosp, Ctr Cardiovasc, Taipei, Taiwan.
C3 Chung Yuan Christian University; National Taiwan University; National
   Taiwan University Hospital; Far Eastern Memorial Hospital
RP Weng, CS (corresponding author), 200 Chung Pei Rd, Chungli, Taiwan.
EM las1012.tw@yahoo.com.tw
RI Lee, Chien-Chang/HHM-5986-2022
OI LEE, BAI-CHIN/0000-0002-7381-4318; Chu, Shu-Hsun/0000-0001-9652-3604
CR Bellamy MF, 1998, CARDIOVASC RES, V40, P410, DOI 10.1016/S0008-6363(98)00184-9
   BOTKER HE, 1996, AM J CARDIOL, V78, P178
   CELERMAJER DS, 1992, LANCET, V340, P1111, DOI 10.1016/0140-6736(92)93147-F
   Cox ID, 2000, CLIN CARDIOL, V23, P645
   Cox ID, 1999, J AM COLL CARDIOL, V34, P455, DOI 10.1016/S0735-1097(99)00224-7
   Crea F, 2004, HEART, V90, P457, DOI 10.1136/hrt.2003.020594
   Desideri G, 2000, CIRCULATION, V102, P2359, DOI 10.1161/01.CIR.102.19.2359
   EGASHIRA K, 1993, NEW ENGL J MED, V328, P1659, DOI 10.1056/NEJM199306103282302
   Enderle MD, 1998, HEART, V80, P349, DOI 10.1136/hrt.80.4.349
   Hasdai D, 1997, CIRCULATION, V96, P3390
   Kaski JC, 2004, CIRCULATION, V109, P568, DOI 10.1161/01.CIR.0000116601.58103.62
   KASKI JC, 1995, BRIT HEART J, V74, P620
   KEMP HG, 1973, AM J MED, V54, P735, DOI 10.1016/0002-9343(73)90060-0
   Kolasinska-Kloch W, 2002, SCAND J CLIN LAB INV, V62, P7, DOI 10.1080/003655102753517145
   Masci PG, 2005, AM J CARDIOL, V95, P1478, DOI 10.1016/j.amjcard.2005.02.018
   Moens AL, 2005, CHEST, V127, P2254, DOI 10.1378/chest.127.6.2254
   Neunteufl T, 1997, ATHEROSCLEROSIS, V129, P111, DOI 10.1016/S0021-9150(96)06018-2
   Rigo F, 2002, AM J CARDIOL, V89, P1141, DOI 10.1016/S0002-9149(02)02292-0
   Sanderson JE, 1997, CARDIOLOGY, V88, P414, DOI 10.1159/000177370
   Schroeder S, 1999, AM HEART J, V138, P731, DOI 10.1016/S0002-8703(99)70189-4
   Teragawa H, 2001, AM J CARDIOL, V88, P1147, DOI 10.1016/S0002-9149(01)02051-3
   WIEDERMANN JG, 1995, J AM COLL CARDIOL, V25, P1310, DOI 10.1016/0735-1097(94)00556-6
NR 22
TC 5
Z9 5
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD OCT-NOV
PY 2008
VL 59
IS 5
BP 581
EP 586
DI 10.1177/0003319707308032
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 366LR
UT WOS:000260483500008
PM 18388101
DA 2025-06-11
ER

PT J
AU Nagasawa, K
   Matsuura, N
   Takeshita, Y
   Ito, S
   Sano, Y
   Yamada, Y
   Uchinaka, A
   Murohara, T
   Nagata, K
AF Nagasawa, K.
   Matsuura, N.
   Takeshita, Y.
   Ito, S.
   Sano, Y.
   Yamada, Y.
   Uchinaka, A.
   Murohara, T.
   Nagata, K.
TI Attenuation of cold stress-induced exacerbation of cardiac and adipose
   tissue pathology and metabolic disorders in a rat model of metabolic
   syndrome by the glucocorticoid receptor antagonist RU486
SO NUTRITION & DIABETES
LA English
DT Article
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; NECROSIS-FACTOR-ALPHA;
   DIASTOLIC DYSFUNCTION; INDUCED HYPERTENSION; HEART-FAILURE; CORTISOL
   SECRETION; NEUROPEPTIDE-Y; BLOOD-PRESSURE; ANIMAL-MODEL; OBESITY
AB OBJECTIVES: Chronic stress affects the central nervous system as well as endocrine, metabolic and immune systems. However, the effects of cold stress on cardiovascular and metabolic disorders in metabolic syndrome (MetS) have remained unclear. We recently characterized DahlS.Z-Lepr(fa)/Lepr(fa) (DS/obese) rats, derived from a cross between Dahl salt-sensitive and Zucker rats, as a new animal model of MetS. We have now investigated the effects of chronic cold stress and glucocorticoid receptor (GR) blockade on cardiac and adipose tissue pathology as well as on metabolic parameters in this model.
   METHODS: DS/obese rats were exposed to cold stress (immersion in ice-cold water to a depth of 1-2 cm for 2 h per day) with or without subcutaneous injection of the GR antagonist RU486 (2 mg kg(-1) day(-1)) for 4 weeks beginning at 9 weeks of age. Age-matched homozygous lean (DahlS.Z-Lepr(+)/Lepr(+)) littermates served as a control.
   RESULTS: Chronic cold stress exacerbated hypertension as well as left ventricular (LV) hypertrophy, fibrosis and diastolic dysfunction in DS/obese rats in a manner sensitive to RU486 treatment. Cold stress with or without RU486 did not affect body weight or fat mass. In contrast, cold stress further increased cardiac oxidative stress as well as macrophage infiltration and proinflammatory gene expression in LV and visceral fat tissue, with all of these effects being attenuated by RU486. Cold stress also further increased GR and 11 beta-hydroxysteroid dehydrogenase type 1 mRNA and protein abundance in LV and visceral adipose tissue, and these effects were again inhibited by RU486. In addition, RU486 ameliorated the stress-induced aggravation of dyslipidemia, glucose intolerance and insulin resistance in DS/obese rats.
   CONCLUSIONS: Our results implicate GR signaling in cold stress-induced exacerbation of cardiac and adipose tissue pathology as well as of abnormal glucose and lipid metabolism in a rat model of MetS.
C1 [Nagasawa, K.; Matsuura, N.; Takeshita, Y.; Ito, S.; Sano, Y.; Yamada, Y.; Uchinaka, A.; Nagata, K.] Dept Pathophysiol Lab Sci, Nagoya, Aichi, Japan.
   [Murohara, T.] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi 4648601, Japan.
C3 Nagoya University
RP Nagata, K (corresponding author), Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Higashi Ku, 1-1-20 Daikominami, Nagoya, Aichi 4618673, Japan.
EM nagata@met.nagoya-u.ac.jp
RI Murohara, Toyoaki/M-4958-2014
FU Ministry of Education, Culture, Sports, Science, and Technology of Japan
   [24590690]; Grants-in-Aid for Scientific Research [24590690] Funding
   Source: KAKEN
FX We thank Dr Shogo Watanabe for technical assistance. This work was
   supported by a grant from the Ministry of Education, Culture, Sports,
   Science, and Technology of Japan (no. 24590690 to KN).
CR Arnaldi G, 2003, J CLIN ENDOCR METAB, V88, P5593, DOI 10.1210/jc.2003-030871
   Bradham WS, 2002, CARDIOVASC RES, V53, P822, DOI 10.1016/S0008-6363(01)00503-X
   Dhuper S, 2011, OBESITY, V19, P128, DOI 10.1038/oby.2010.134
   Esler M, 2006, HYPERTENSION, V48, P787, DOI 10.1161/01.HYP.0000242642.42177.49
   EVANS RM, 1988, SCIENCE, V240, P889, DOI 10.1126/science.3283939
   Filipovsky J, 1996, J HYPERTENS, V14, P229, DOI 10.1097/00004872-199602000-00012
   Hall JE, 2010, J BIOL CHEM, V285, P17271, DOI 10.1074/jbc.R110.113175
   Hattori T, 2011, NUTR DIABETES, V1, DOI 10.1038/nutd.2010.1
   Hattori T, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.114.001312
   Hattori T, 2013, NAGOYA J MED SCI, V75, P81
   Hermoso MA, 2004, MOL CELL BIOL, V24, P4743, DOI 10.1128/MCB.24.11.4743-4756.2004
   Hu LX, 2006, AM J HYPERTENS, V19, P413, DOI 10.1016/j.amjhyper.2005.09.023
   Kamei N, 2006, J BIOL CHEM, V281, P26602, DOI 10.1074/jbc.M601284200
   Kato MF, 2008, J HYPERTENS, V26, P1669, DOI 10.1097/HJH.0b013e328302f0f7
   Kotsis V, 2010, HYPERTENS RES, V33, P386, DOI 10.1038/hr.2010.9
   Kuo LE, 2007, NAT MED, V13, P803, DOI 10.1038/nm1611
   Kuo LE, 2008, ANN NY ACAD SCI, V1148, P232, DOI 10.1196/annals.1410.035
   Lister K, 2006, CARDIOVASC RES, V70, P555, DOI 10.1016/j.cardiores.2006.02.010
   Masuzaki H, 2003, J CLIN INVEST, V112, P83, DOI [10.1172/JCI200317845, 10.1172/JCI17845]
   Masuzaki H, 2001, SCIENCE, V294, P2166, DOI 10.1126/science.1066285
   Matsuura N, 2015, AM J PHYSIOL-HEART C, V308, pH1275, DOI 10.1152/ajpheart.00906.2014
   Matsuura N, 2015, INT J CARDIOL, V179, P360, DOI 10.1016/j.ijcard.2014.11.099
   McKenna NJ, 1999, ENDOCR REV, V20, P321, DOI 10.1210/er.20.3.321
   Meléndez GC, 2010, HYPERTENSION, V56, P225, DOI 10.1161/HYPERTENSIONAHA.109.148635
   Mikurube Hajime, 2005, Nihon Koshu Eisei Zasshi, V52, P987
   Miyata K, 2005, J AM SOC NEPHROL, V16, P2906, DOI 10.1681/ASN.2005040390
   Montagne CT, 2000, DIABETES, V49, P883, DOI 10.2337/diabetes.49.6.883
   Morton NM, 2008, FRONT HORM RES, V36, P146, DOI 10.1159/000115363
   Murase T, 2012, HYPERTENS RES, V35, P186, DOI 10.1038/hr.2011.157
   Nagata K, 2006, HYPERTENSION, V47, P656, DOI 10.1161/01.HYP.0000203772.78696.67
   Nagata K, 2002, HYPERTENSION, V40, P168, DOI 10.1161/01.HYP.0000026668.50222.1E
   Pacák K, 2001, ENDOCR REV, V22, P502, DOI 10.1210/er.22.4.502
   Reynolds RM, 2001, J CLIN ENDOCR METAB, V86, P245, DOI 10.1210/jc.86.1.245
   Rickard AJ, 2006, ENDOCRINOLOGY, V147, P5901, DOI 10.1210/en.2006-0658
   Rose AJ, 2010, J STEROID BIOCHEM, V122, P10, DOI 10.1016/j.jsbmb.2010.02.010
   Rosmond R, 1998, J CLIN ENDOCR METAB, V83, P1853, DOI 10.1210/jc.83.6.1853
   Sakata Y, 2004, CIRCULATION, V109, P2143, DOI 10.1161/01.CIR.0000125741.88712.77
   Staab CA, 2010, J STEROID BIOCHEM, V119, P56, DOI 10.1016/j.jsbmb.2009.12.013
   Takatsu M, 2013, HYPERTENSION, V62, P957, DOI 10.1161/HYPERTENSIONAHA.113.02093
   Takatsu M, 2012, J HYPERTENS, V30, P1845, DOI 10.1097/HJH.0b013e3283567645
   Takeshita Y, 2015, HYPERTENS RES, V38, P741, DOI 10.1038/hr.2015.77
   Vandevyver S, 2013, ENDOCRINOLOGY, V154, P993, DOI 10.1210/en.2012-2045
   Walker BR, 1998, HYPERTENSION, V31, P891, DOI 10.1161/01.HYP.31.4.891
   Walker BR, 2007, EUR J ENDOCRINOL, V157, P545, DOI 10.1530/EJE-07-0455
   Wang Minghan, 2005, Nutr Metab (Lond), V2, P3, DOI 10.1186/1743-7075-2-3
   Weber KT, 2004, HYPERTENSION, V43, P716, DOI 10.1161/01.HYP.0000118586.38323.5b
   Whitehurst RM, 1999, J MOL CELL CARDIOL, V31, P1551, DOI 10.1006/jmcc.1999.0990
   Wilckens T, 1997, IMMUNOL TODAY, V18, P418, DOI 10.1016/S0167-5699(97)01111-0
   Xu JL, 2005, HYPERTENSION, V46, P719, DOI 10.1161/01.HYP.0000185189.46698.15
   Yamada T, 2009, EUR J PHARMACOL, V615, P163, DOI 10.1016/j.ejphar.2009.05.028
   Zhang Y, 2005, AM J HYPERTENS, V18, P910, DOI 10.1016/j.amjhyper.2005.02.017
NR 51
TC 14
Z9 17
U1 5
U2 15
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2044-4052
J9 NUTR DIABETES
JI Nutr. Diabetes
PD APR 25
PY 2016
VL 6
AR e207
DI 10.1038/nutd.2016.14
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA DK2IO
UT WOS:000374738100004
PM 27110688
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sone, H
   Horikawa, C
   Tanaka-Mizuno, S
   Kawasaki, R
   Fujihara, K
   Moriya, T
   Araki, A
   Tanaka, S
   Akanuma, Y
AF Sone, Hirohito
   Horikawa, Chika
   Tanaka-Mizuno, Sachiko
   Kawasaki, Ryo
   Fujihara, Kazuya
   Moriya, Tatsumi
   Araki, Atsushi
   Tanaka, Shiro
   Akanuma, Yasuo
TI Japan Diabetes Complications Study: Revisiting one of the first
   large-scale clinical studies in East Asians with diabetes
SO JOURNAL OF DIABETES INVESTIGATION
LA English
DT Review; Early Access
DE East Asia; large-scale clinical study; Lifestyle
ID CORONARY-HEART-DISEASE; RENAL-FUNCTION DECLINE; ALL-CAUSE MORTALITY;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; PHYSICAL-ACTIVITY;
   RISK-FACTOR; TYPE-2; RETINOPATHY; PREDICTOR
AB This review highlights the significance of the Japan Diabetes Complications Study (JDCS), one of the earliest large-scale studies of people with type 2 diabetes outside Europe and the United States, in understanding type 2 diabetes mellitus among East Asian populations, particularly in Japan. Historically, large-scale clinical studies on type 2 diabetes mellitus have predominantly focused on Western populations, despite East Asians comprising the largest proportion of diabetic patients globally. The JDCS, which was initiated in 1996, enrolled 2,033 Japanese type 2 diabetes mellitus patients. It aimed to evaluate the effects of intensive lifestyle interventions on diabetic complications. The study demonstrated that lifestyle-focused interventions significantly reduced the risk of stroke and other complications compared to conventional treatment. Key findings of its sub-analyses include the unique characteristics of Japanese patients with type 2 diabetes mellitus, such as their lower body mass index (BMI) compared to Western counterparts and a stronger association between even modest BMI increases and beta cell dysfunction. Additionally, the JDCS provided insights into the risk factors for nephropathy, retinopathy, and macrovascular complications, emphasizing the importance of controlling blood pressure, glycemia, and lifestyle factors. The study also explored the impact of diet, exercise, and mental health on diabetic outcomes, revealing the protective effects of physical activity and a balanced diet, while highlighting the risks associated with high salt intake and depression. A risk prediction model tailored to Japanese patients was also developed. Overall, this study made a significant contribution to the evidence-based management of type 2 diabetes mellitus in East Asia.
C1 [Sone, Hirohito; Fujihara, Kazuya] Niigata Univ, Fac Med, Dept Hematol Endocrinol & Metab, Niigata, Japan.
   [Horikawa, Chika] Univ Niigata Prefecture, Fac Human Life Studies, Dept Hlth & Nutr, Niigata, Japan.
   [Tanaka-Mizuno, Sachiko] Kobe Pharmaceut Univ, Lab Epidemiol & Prevent, Kobe, Japan.
   [Kawasaki, Ryo] Osaka Univ, Grad Sch Med, Dept Social Med, Div Publ Hlth, Osaka, Japan.
   [Moriya, Tatsumi] Kitasato Univ, Hlth Care Ctr, Sagamihara, Japan.
   [Araki, Atsushi] Tokyo Metropolitan Inst Geriatr & Gerontol, Dept Diabet Metab & Endocrinol, Tokyo, Japan.
   [Tanaka, Shiro] Kyoto Univ, Grad Sch Med, Dept Clin Biostat, Kyoto, Japan.
   [Akanuma, Yasuo] Asahi Life Fdn, Inst Med Sci, Tokyo, Japan.
C3 Niigata University; University Niigata Prefecture; Kobe Pharmaceutical
   University; The University of Osaka; Kitasato University; Kyoto
   University; Asahi Life Foundation
RP Sone, H (corresponding author), Niigata Univ, Fac Med, Dept Hematol Endocrinol & Metab, Niigata, Japan.
EM sone@med.niigata-u.ac.jp
RI Horikawa, Chika/MBG-7140-2025; Kawasaki, Ryo/B-8859-2015; Araki,
   Atsushi/JVE-0081-2024; 田中, 司朗/GON-6916-2022; Sone,
   Hirohito/ABC-9346-2021
OI Sone, Hirohito/0000-0003-1263-2817; Fujihara, Kazuya/0000-0001-6725-4169
FU The Japan Society for the Promotion of Science; Ministry of Health,
   Labour and Welfare of Japan; Japan Society for the Promotion of Science
FX We would like to express our sincere gratitude and condolences to the
   late Prof. Nobuhiro Yamada and the late Prof. Yasuo Ohashi, who were
   founding members of the JDCS. In addition, we would like to express our
   deepest gratitude to the many study group members and participants who
   cooperated with the JDCS, including Prof. Satoshi Iimuro
   (biostatistics), Prof. Shun Ishibashi (macroangiopathy), Prof. Shigehiro
   Katayama (nephropathy), Prof. Hidetoshi Yamashita (retinopathy), and
   Prof. Yukio Yoshimura (nutritional therapy). The JDCS was financially
   supported by the Ministry of Health, Labour and Welfare of Japan and the
   Japan Society for the Promotion of Science.
CR Budhathoki S, 2019, JAMA INTERN MED, V179, P1509, DOI 10.1001/jamainternmed.2019.2806
   Fujihara K, 2020, BMJ OPEN DIAB RES CA, V8, DOI 10.1136/bmjdrc-2019-000901
   Horikawa C, 2020, EUR J NUTR, V59, P1585, DOI 10.1007/s00394-019-02014-4
   Horikawa C, 2019, EUR J NUTR, V58, P281, DOI 10.1007/s00394-017-1592-y
   Horikawa C, 2017, NUTRIENTS, V9, DOI 10.3390/nu9020113
   Horikawa C, 2014, J CLIN ENDOCR METAB, V99, P3635, DOI 10.1210/jc.2013-4315
   Horikawa C, 2014, J DIABETES INVEST, V5, P176, DOI 10.1111/jdi.12146
   Katayama S, 2011, DIABETOLOGIA, V54, P1025, DOI 10.1007/s00125-010-2025-0
   Kawasaki R, 2011, DIABETOLOGIA, V54, P2288, DOI 10.1007/s00125-011-2199-0
   Kawasaki R, 2013, OPHTHALMOLOGY, V120, P574, DOI 10.1016/j.ophtha.2012.08.029
   Kodama S, 2013, DIABETES CARE, V36, P471, DOI 10.2337/dc12-0783
   Kodama S, 2009, DIABETES CARE, V32, P959, DOI 10.2337/dc08-1716
   Li L, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.780557
   Matsuba I, 2012, DIABETES CARE, V35, P1853, DOI 10.2337/dc12-0156
   Matsunaga S, 2017, J PSYCHOSOM RES, V99, P34, DOI 10.1016/j.jpsychores.2017.05.020
   Moriya T, 2017, J DIABETES COMPLICAT, V31, P473, DOI 10.1016/j.jdiacomp.2016.06.020
   Moriya T, 2013, DIABETES CARE, V36, P2803, DOI 10.2337/dc12-2327
   Naghshi S, 2020, BMJ-BRIT MED J, V370, DOI 10.1136/bmj.m2412
   Osawa T, 2021, J INVEST MED, V69, P724, DOI 10.1136/jim-2020-001489
   Osawa T, 2019, DIABETES-METAB RES, V35, DOI 10.1002/dmrr.3120
   Qi L, 2007, DIABETES CARE, V30, P101, DOI 10.2337/dc06-1686
   Reynolds AN, 2020, PLOS MED, V17, DOI 10.1371/journal.pmed.1003053
   Saito K, 2007, DIABETES CARE, V30, P1286, DOI 10.2337/dc06-2149
   Sone H, 2005, DIABETES CARE, V28, P1463, DOI 10.2337/diacare.28.6.1463
   Sone H, 2006, DIABETES CARE, V29, P145, DOI 10.2337/diacare.29.01.06.dc05-1341
   Sone H, 2013, DIABETOLOGIA, V56, P1021, DOI 10.1007/s00125-012-2810-z
   Sone H, 2002, HORM METAB RES, V34, P509, DOI 10.1055/s-2002-34791
   Sone H, 2010, DIABETOLOGIA, V53, P419, DOI 10.1007/s00125-009-1622-2
   Sone H, 2003, LANCET, V361, P85, DOI 10.1016/S0140-6736(03)12151-4
   Sone H, 2012, DIABETES CARE, V35, P1150, DOI 10.2337/dc11-1412
   Sone H, 2011, J CLIN ENDOCR METAB, V96, P3448, DOI 10.1210/jc.2011-0622
   Takeuchi M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13103428
   Tanaka S, 2017, DIABETES METAB, V43, P424, DOI 10.1016/j.diabet.2017.06.002
   Tanaka S, 2014, J CLIN ENDOCR METAB, V99, pE2692, DOI 10.1210/jc.2014-1855
   Tanaka S, 2014, INT J EPIDEMIOL, V43, P1054, DOI 10.1093/ije/dyt057
   Tanaka S, 2013, DIABETES CARE, V36, P3916, DOI 10.2337/dc13-0654
   Tanaka S, 2013, DIABETES CARE, V36, P1193, DOI 10.2337/dc12-0958
   Tanaka S, 2013, EPIDEMIOLOGY, V24, P204, DOI 10.1097/EDE.0b013e318281725e
   Ueki K, 2017, LANCET DIABETES ENDO, V5, P951, DOI 10.1016/S2213-8587(17)30327-3
   Yamada MH, 2021, DIABETES CARE, V44, P2124, DOI 10.2337/dc20-2252
   Yamamoto M, 2019, INVEST OPHTH VIS SCI, V60, P2685, DOI 10.1167/iovs.19-26749
   Yamamoto M, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.118.010627
   Yamaoka T, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061629
NR 43
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2040-1116
EI 2040-1124
J9 J DIABETES INVEST
JI J. Diabetes Investig.
PD 2024 DEC 24
PY 2024
DI 10.1111/jdi.14394
EA DEC 2024
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA Q0W3Z
UT WOS:001381993700001
PM 39716905
OA gold
DA 2025-06-11
ER

PT J
AU Veru-Lesmes, F
   Rho, A
   King, S
   Joober, R
   Pruessner, M
   Malla, A
   Iyer, SN
AF Veru-Lesmes, Franz
   Rho, Aldanie
   King, Suzanne
   Joober, Ridha
   Pruessner, Marita
   Malla, Ashok
   Iyer, Srividya N.
TI Social Determinants of Health and Preclinical Glycemic Control in Newly
   Diagnosed First-Episode Psychosis Patients
SO CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
LA English
DT Article
DE first episode psychosis; social determinants; biopsychosocial; child
   maltreatment; race; immigrant mental health; income inequality
ID BODY-MASS INDEX; CHILDHOOD TRAUMA; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; ETHNIC-GROUPS; OBESITY; SCHIZOPHRENIA; METAANALYSIS; RISK;
   ASSOCIATIONS
AB Background: The abnormally high incidence of disorders of glucose metabolism (DGM) in psychotic-spectrum disorders (PSD) has often been attributed to the side effects of antipsychotics and unhealthy lifestyles. The influence of social determinants of health has been largely ignored, despite ample evidence linking social adversity with both PSD and DGM. The aim of this study is to examine the influence of well-established social determinants of health on preclinical levels of glycated hemoglobin (HbA1c) in a sample of first-episode psychosis (FEP) patients.
   Methods: In a sample of newly admitted FEP patients, univariate analyses were used to select the main predictors of HbA1c levels from the following social determinants of health: childhood trauma, immigrant background, visible minority status, and indices of social and material deprivation. The predictors identified in the univariate analyses were tested in multivariate linear regression models including age, sex, BMI, depression, and physical anergia (proxy of sedentary behaviour) as covariates.
   Results: Univariate analyses identified visible minority status and childhood physical abuse as predictors of HbA1c. After controlling for covariates, minority status significantly predicted higher levels of glycated hemoglobin ( = 0.23; P = 0.01), and physical abuse had a marginally significant effect ( = 0.23; P = 0.06). Other predictors were not significantly associated.
   Conclusion: FEP patients from a visible minority or who were victims of childhood physical abuse have higher levels of HbA1c at admission compared with other patients. This might suggest an increase in risk for the development of future DGM. If confirmed, preventive strategies could be tailored for these groups.
C1 [Veru-Lesmes, Franz; Rho, Aldanie; Joober, Ridha; Pruessner, Marita; Malla, Ashok; Iyer, Srividya N.] Prevent & Early Intervent Program Psychosis, Montreal, PQ, Canada.
   [Veru-Lesmes, Franz; Rho, Aldanie; King, Suzanne; Joober, Ridha; Pruessner, Marita; Malla, Ashok; Iyer, Srividya N.] Douglas Mental Hlth Univ Inst, 6875 LaSalle Blvd, Montreal, PQ H4H 1R3, Canada.
   [Veru-Lesmes, Franz; King, Suzanne; Joober, Ridha; Pruessner, Marita; Malla, Ashok; Iyer, Srividya N.] McGill Univ, Dept Psychiat, Montreal, PQ, Canada.
   [Pruessner, Marita] Univ Konstanz, Dept Psychol, Constance, Germany.
C3 McGill University; University of Konstanz
RP Iyer, SN (corresponding author), Douglas Mental Hlth Univ Inst, 6875 LaSalle Blvd, Montreal, PQ H4H 1R3, Canada.
EM srividya.iyer@mcgill.ca
RI King, Suzanne/AAM-8541-2020; Iyer, Srividya/AAU-2256-2021
OI Iyer, Srividya/0000-0001-5367-9086; Rho, Aldanie/0000-0001-8063-6655
FU Canadian Institutes of Health Research; National Institute of Mental
   Health [MH093303]; Fonds de recherche du Quebec - Sante; Canada Research
   Chairs Program; Fonds de recherche du Quebec-Sante; Schizophrenia
   Society of Canada Foundation; Canadian College of
   Neuropsychopharmacology
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: The present
   project was funded by operating grants from the Canadian Institutes of
   Health Research and the National Institute of Mental Health (MH093303).
   Dr. S.N. Iyer has received salary awards from the Fonds de recherche du
   Quebec - Sante and from the Canadian Institutes of Health Research. Dr.
   A. Malla is supported by the Canada Research Chairs Program. Dr. R.
   Joober has received salary awards from the Fonds de recherche du Quebec
   - Sante. Dr. F. Veru-Lesmes is supported through a doctoral training
   award granted by the Fonds de recherche du Quebec-Sante, and a doctoral
   studentship from the Schizophrenia Society of Canada Foundation and
   Canadian College of Neuropsychopharmacology.
CR ADDINGTON D, 1993, BRIT J PSYCHIAT, V163, P39, DOI 10.1192/S0007125000292581
   Anderson KK, 2012, CAN J PSYCHIAT, V57, P626, DOI 10.1177/070674371205701007
   Andreasen N.C., 1984, Scale for the assessment of negative symptoms (SANS)
   Andreasen NC., 1984, The Scale for the Assessment of Positive Symptoms (SAPS)
   Auchincloss AH, 2008, EPIDEMIOLOGY, V19, P146, DOI 10.1097/EDE.0b013e31815c480
   Bernstein DP, 2003, CHILD ABUSE NEGLECT, V27, P169, DOI 10.1016/S0145-2134(02)00541-0
   Boydell J, 2004, SOC PSYCH PSYCH EPID, V39, P597, DOI 10.1007/s00127-004-0789-6
   Cassidy CM, 2010, J CLIN PSYCHOPHARM, V30, P64, DOI 10.1097/JCP.0b013e3181ca03df
   Chiu M, 2011, DIABETES CARE, V34, P1741, DOI 10.2337/dc10-2300
   Cozier YC, 2014, AM J EPIDEMIOL, V179, P875, DOI 10.1093/aje/kwu004
   Danese A, 2014, MOL PSYCHIATR, V19, P544, DOI 10.1038/mp.2013.54
   Dankner R, 2013, DIABETES-METAB RES, V29, P1, DOI 10.1002/dmrr.2373
   Dankner R, 2009, DIABETES CARE, V32, P1464, DOI 10.2337/dc09-0153
   Dave JM, 2009, J AM DIET ASSOC, V109, P697, DOI 10.1016/j.jada.2008.12.017
   Deurenberg P, 1998, INT J OBESITY, V22, P1164, DOI 10.1038/sj/ijo/0800741
   Duncan AE, 2015, PREV CHRONIC DIS, V12, DOI 10.5888/pcd12.140434
   Færch K, 2010, DIABETOLOGIA, V53, P858, DOI 10.1007/s00125-010-1673-4
   Falkner B, 2014, CURR HYPERTENS REP, V16, DOI 10.1007/s11906-014-0449-5
   Ford PB, 2008, NUTR REV, V66, P216, DOI 10.1111/j.1753-4887.2008.00026.x
   Gallagher D, 1996, AM J EPIDEMIOL, V143, P228, DOI 10.1093/oxfordjournals.aje.a008733
   Geer EB, 2009, GENDER MED, V6, P60, DOI 10.1016/j.genm.2009.02.002
   GOLDMAN HH, 1992, AM J PSYCHIAT, V149, P1148
   GOLDSTEIN DE, 1984, CRC CR REV CL LAB SC, V21, P187, DOI 10.3109/10408368409165782
   GOTTFRIED AW, 1985, MERRILL PALMER QUART, V31, P85
   Hall WJ, 2015, AM J PUBLIC HEALTH, V105, pE60, DOI 10.2105/AJPH.2015.302903
   Heymsfield SB, 2016, OBES REV, V17, P262, DOI 10.1111/obr.12358
   Hjorthoj C, 2017, LANCET PSYCHIAT, V4, P295, DOI 10.1016/S2215-0366(17)30078-0
   Holt RIG, 2009, DIABETES OBES METAB, V11, P665, DOI 10.1111/j.1463-1326.2009.01038.x
   Huang H, 2015, METABOLISM, V64, P1408, DOI 10.1016/j.metabol.2015.08.019
   Ishizawa H, 2016, J URBAN AFF, V38, P298, DOI 10.1111/juaf.12208
   Iyer S, 2015, J NERV MENT DIS, V203, P356, DOI 10.1097/NMD.0000000000000288
   Khun K, 2008, REGARD DEFAVORISATIO
   Kirkbride JB, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031660
   Kohen D, 2004, BRIT J PSYCHIAT, V184, pS64, DOI 10.1192/bjp.184.47.s64
   Leao TS, 2006, J NERV MENT DIS, V194, P27, DOI 10.1097/01.nmd.0000195312.81334.81
   Lee C, 2014, SOC SCI MED, V105, P122, DOI 10.1016/j.socscimed.2014.01.017
   Lewis TT, 2011, AM J EPIDEMIOL, V173, P1223, DOI 10.1093/aje/kwq466
   Marshall BDL, 2013, AM J PUBLIC HEALTH, V103, pE69, DOI 10.2105/AJPH.2013.301257
   McGrath J, 2008, EPIDEMIOL REV, V30, P67, DOI 10.1093/epirev/mxn001
   McIntyre R.S., 2005, Can. J. Diabetes, V29, P122
   Norman RMG, 2004, PSYCHOL MED, V34, P255, DOI 10.1017/S0033291703001119
   O'Donoghue B, 2016, PSYCHOL MED, V46, P1367, DOI 10.1017/S003329171500286X
   Olson DE, 2010, DIABETES CARE, V33, P2184, DOI 10.2337/dc10-0433
   Pampalon R, 2000, Chronic Dis Can, V21, P104
   Perry BI, 2016, LANCET PSYCHIAT, V3, P1049, DOI 10.1016/S2215-0366(16)30262-0
   Ross CE, 2001, J HEALTH SOC BEHAV, V42, P258, DOI 10.2307/3090214
   Rossen LM, 2014, J EPIDEMIOL COMMUN H, V68, P123, DOI 10.1136/jech-2012-202245
   Samele C, 2007, SOC PSYCH PSYCH EPID, V42, P117, DOI 10.1007/s00127-006-0135-2
   Senese LC, 2009, EPIDEMIOL REV, V31, P21, DOI 10.1093/epirev/mxp006
   Statistics Canada, 2017, PREV STAND VIS MIN
   Stevens J, 2003, INT J OBESITY, V27, P1297, DOI 10.1038/sj.ijo.0802417
   Stubbs B, 2015, ACTA PSYCHIAT SCAND, V132, P144, DOI 10.1111/acps.12439
   Tamashiro KL, 2011, STRESS, V14, P468, DOI 10.3109/10253890.2011.606341
   Varese F, 2012, SCHIZOPHRENIA BULL, V38, P661, DOI 10.1093/schbul/sbs050
   Vlassopoulos A, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-1013
   Wang L, 2013, SOC SCI MED, V98, P8, DOI 10.1016/j.socscimed.2013.08.040
   Wang Y, 2007, EPIDEMIOL REV, V29, P6, DOI 10.1093/epirev/mxm007
   Wells JCK, 2012, OBES REV, V13, P14, DOI 10.1111/j.1467-789X.2012.01034.x
   Wilcox S, 2013, NUTR RES, V33, P636, DOI 10.1016/j.nutres.2013.05.007
   Zeigler-Johnson C, 2013, J NATL MED ASSOC, V105, P173, DOI 10.1016/S0027-9684(15)30107-3
NR 60
TC 15
Z9 15
U1 0
U2 14
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0706-7437
EI 1497-0015
J9 CAN J PSYCHIAT
JI Can. J. Psychiat.-Rev. Can. Psychiat.
PD AUG
PY 2018
VL 63
IS 8
BP 547
EP 556
DI 10.1177/0706743718762097
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GQ0DX
UT WOS:000441288000006
PM 29661027
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Mourtzi, N
   Yannakoulia, M
   Ntanasi, E
   Kosmidis, MH
   Anastasiou, CA
   Dardiotis, E
   Hadjigeorgiou, G
   Megalou, M
   Sakka, P
   Scarmeas, N
AF Mourtzi, N.
   Yannakoulia, M.
   Ntanasi, E.
   Kosmidis, M. H.
   Anastasiou, C. A.
   Dardiotis, E.
   Hadjigeorgiou, G.
   Megalou, M.
   Sakka, P.
   Scarmeas, N.
TI History of induced abortions and frailty in older Greek women: results
   from the HELIAD study
SO EUROPEAN GERIATRIC MEDICINE
LA English
DT Article
DE Frailty; Abortions; Women; Greece
ID GERIATRIC DEPRESSION SCALE; METABOLIC SYNDROME; RHEUMATOID-ARTHRITIS;
   INSULIN-RESISTANCE; CHINESE WOMEN; MENTAL-HEALTH; ADULTS;
   MICROCHIMERISM; ASSOCIATION; RISK
AB Purpose Women are almost twice as likely as men to develop frailty and early-traumatic experiences related to reproduction may have a role to play. The purpose of this study was to investigate the association between a history of induced abortions and risk of frailty.
   Methods 1062 women aged >= 65 years from the HELIAD study were included in the present cross-sectional study. Frailty was assessed by frailty index and Fried definitions. The history of abortion and of other reproductive experiences (age onset of menstruation, age of menopause, number of offspring, and number of miscarriages) was obtained by all participants. Logistic and linear regression analyses were performed to examine whether the number of abortions was related to frailty.
   Results When frailty was defined with frailty index, women with 1 or 2 abortions had 1.7 higher risk of frailty compared to women with no history of abortions, while those with more than 3 abortions had more than a twofold higher risk of frailty. Two supplementary analyses excluding women with surgical operations' history and women with dementia revealed similar results. When frailty was defined with Fried definition, the analysis was marginally significant when abortion was inserted as a categorical variable. Women with more than 3 abortions showed 2.4 higher risk of frailty compared to women with no history of abortion.
   Conclusion The number of induced abortions was associated with moderate higher odds of frailty, when frailty was defined according to frailty index. A similar trend was revealed in the model with Fried definition after trichotomization of abortions.
C1 [Mourtzi, N.; Anastasiou, C. A.; Scarmeas, N.] Univ Athens, Aeginit Hosp, Neurol Clin 1, Dept Social Med Psychiat & Neurol, Vasilissis Sofias 72, Athens 11528, Greece.
   [Yannakoulia, M.; Ntanasi, E.; Anastasiou, C. A.] Harokopio Univ, Dept Nutr & Dietet, Athens, Greece.
   [Kosmidis, M. H.] Aristotle Univ Thessaloniki, Sch Psychol, Lab Cognit Neurosci, Thessaloniki, Greece.
   [Dardiotis, E.; Hadjigeorgiou, G.] Univ Thessaly, Sch Med, Larisa, Greece.
   [Megalou, M.] Biomed Diagnost Lab, Athens, Greece.
   [Ntanasi, E.; Sakka, P.] Athens Assoc Alzheimers Dis & Related Disorders, Maroussi, Greece.
   [Scarmeas, N.] Columbia Univ, Gertrude H Sergievsky Ctr, Dept Neurol, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10027 USA.
C3 National & Kapodistrian University of Athens; Harokopio University
   Athens; Aristotle University of Thessaloniki; University of Thessaly;
   Columbia University
RP Scarmeas, N (corresponding author), Univ Athens, Aeginit Hosp, Neurol Clin 1, Dept Social Med Psychiat & Neurol, Vasilissis Sofias 72, Athens 11528, Greece.; Scarmeas, N (corresponding author), Columbia Univ, Gertrude H Sergievsky Ctr, Dept Neurol, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10027 USA.
EM ns257@cumc.columbia.edu
RI Kosmidis, Mary/AAN-2104-2021; Scarmeas, Nikolaos/AAD-2512-2020
OI Dardiotis, Efthimios/0000-0003-2957-641X; Anastasiou,
   Costas/0000-0002-3536-3034; Yannakoulia, Mary/0000-0003-2171-7337;
   Kosmidis, Mary/0000-0001-8790-1220; Ntanasi, Eva/0000-0001-9311-0994
FU Alzheimer's Association [IIRG-09-133014]; ESPA-EU program Excellence
   Grant (ARISTEIA) [189 10276/8/9/2011]; Ministry for Health and Social
   Solidarity (Greece) [Delta(sic)2beta/omicroniotakappa0.51657/14.4.2009]
FX This study was supported by the Grants: IIRG-09-133014 from the
   Alzheimer's Association, 189 10276/8/9/2011 from the ESPA-EU program
   Excellence Grant (ARISTEIA) and the Delta(sic)2 beta/omicron iota kappa
   0.51657/14.4.2009 of the Ministry for Health and Social Solidarity
   (Greece).
CR Abbud M, 2002, TRANSPL P, V34, P2951, DOI 10.1016/S0041-1345(02)03501-7
   Anastasiou CA, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0182048
   Barile-Fabris Leonor A, 2016, Rev Med Inst Mex Seguro Soc, V54 Suppl 2, pS210
   Barmpouti A, 2015, THESIS
   Barzilay JI, 2007, ARCH INTERN MED, V167, P635, DOI 10.1001/archinte.167.7.635
   Bountziouka V, 2012, NUTR METAB CARDIOVAS, V22, P659, DOI 10.1016/j.numecd.2010.10.015
   Claridge AM, 2013, WOMEN HEALTH, V53, P777, DOI 10.1080/03630242.2013.831018
   Cruz GI, 2017, ANN RHEUM DIS, V76, P1405, DOI 10.1136/annrheumdis-2016-210662
   Dardiotis E, 2014, NEUROEPIDEMIOLOGY, V43, P9, DOI 10.1159/000362723
   Fine-Davis M, 2017, REPORT
   Fountoulakis KN, 1999, AGING CLIN EXP RES, V11, P367, DOI 10.1007/BF03339814
   Freitag Simone, 2016, Geriatrics (Basel), V1, DOI 10.3390/geriatrics1040026
   Fried LP, 2001, J GERONTOL A-BIOL, V56, pM146, DOI 10.1093/gerona/56.3.M146
   Gobbens RJJ, 2010, J NUTR HEALTH AGING, V14, P175, DOI 10.1007/s12603-010-0045-6
   Gordon EH, 2017, EXP GERONTOL, V89, P30, DOI 10.1016/j.exger.2016.12.021
   Gottfredson LS, 2004, J PERS SOC PSYCHOL, V86, P174, DOI 10.1037/0022-3514.86.1.174
   Hubbard RE, 2011, MATURITAS, V69, P203, DOI 10.1016/j.maturitas.2011.04.006
   Katz PP, 2016, ARTHRITIS RHEUMATOL, P68
   Kavouras S.A., 2016, Sci Sports, V31, pe47
   Kinsella K, 2005, POPUL BULL, V60, P3
   Lenze EJ, 2001, AM J GERIAT PSYCHIAT, V9, P113, DOI 10.1176/appi.ajgp.9.2.113
   Lohman M, 2016, J GERONTOL B-PSYCHOL, V71, P630, DOI 10.1093/geronb/gbu180
   Major B, 2009, AM PSYCHOL, V64, P863, DOI 10.1037/a0017497
   Miech RP, 2010, INT J CLIN EXP MED, V3, P164
   Mitnitski A, 2005, J AM GERIATR SOC, V53, P2184, DOI 10.1111/j.1532-5415.2005.00506.x
   Ntanasi E, 2018, J AM MED DIR ASSOC, V19, P315, DOI 10.1016/j.jamda.2017.11.005
   Ortolá R, 2016, J GERONTOL A-BIOL, V71, P251, DOI 10.1093/gerona/glv125
   POSNER BM, 1993, AM J PUBLIC HEALTH, V83, P972, DOI 10.2105/AJPH.83.7.972
   Rak JM, 2009, ARTHRITIS RHEUM-US, V60, P73, DOI 10.1002/art.24224
   Reardon DC, 2002, BRIT MED J, V324, P151, DOI 10.1136/bmj.324.7330.151
   Rockwood K, 2007, J GERONTOL A-BIOL, V62, P722, DOI 10.1093/gerona/62.7.722
   Roubenoff R, 2004, OBES RES, V12, P887, DOI 10.1038/oby.2004.107
   SHEIKH J I, 1986, Clinical Gerontologist, V5, P165
   Smit E, 2013, BRIT J NUTR, V110, P172, DOI 10.1017/S000711451200459X
   Stenholm S, 2011, J GERONTOL A-BIOL, V66, P341, DOI 10.1093/gerona/glq226
   Thorp JM, 2003, OBSTET GYNECOL SURV, V58, P67, DOI 10.1097/00006254-200301000-00023
   Tsapanou A, 2017, NEUROBIOL LEARN MEM, V141, P217, DOI 10.1016/j.nlm.2017.04.011
   Viscogliosi G, 2016, J AM MED DIR ASSOC, V17, P956, DOI 10.1016/j.jamda.2016.06.018
   Wu J, 2015, J WOMENS HEALTH, V24, P602, DOI 10.1089/jwh.2014.5134
   Xu BH, 2013, FRONT MED-PRC, V7, P132, DOI 10.1007/s11684-013-0250-x
   YESAVAGE JA, 1988, PSYCHOPHARMACOL BULL, V24, P709
NR 41
TC 7
Z9 8
U1 1
U2 13
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1878-7649
EI 1878-7657
J9 EUR GERIATR MED
JI Eur. Geriatr. Med.
PD JUN
PY 2018
VL 9
IS 3
BP 301
EP 310
DI 10.1007/s41999-018-0047-1
PG 10
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA GH4ND
UT WOS:000433379500004
PM 34654241
DA 2025-06-11
ER

PT J
AU Sernyak, MJ
AF Sernyak, Michael J.
TI Implementation of monitoring and management guidelines for
   second-generation antipsychotics
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article; Proceedings Paper
CT Meeting on Strategies to Integrate Physical Health Care Into Mental
   Health
CY AUG 28, 2006
CL Philadelphia, PA
ID MEDICAL-CARE; SCHIZOPHRENIA; MORTALITY
AB It has long been known that psychiatric patients experience increased morbidity and mortality associated with a range of physical disorders. Lifestyle, inadequate health care, and a variety of other factors all contribute to the poor physical health of people with severe mental illness. Second-generation antipsychotics have gained widespread acceptance for the management of patients with schizophrenia and other forms of severe mental illness. While demonstrating several advantages over first-generation antipsychotics, second-generation antipsychotics have been found to cause or exacerbate several metabolic disorders, including diabetes, obesity, dyslipidemia, and metabolic syndrome. These disorders are closely linked and consistently associated with the development of cardiovascular disease, with varying prevalence rates depending on the second-generation antipsychotic used. As a result, several authoritative guidelines have been developed for the monitoring and management of metabolic disturbances in schizophrenia and other forms of severe mental illness. Specifically, the guidelines and recommendations generated from the Mount Sinai Conference on Medical Monitoring and the American Diabetes Association/American Psychiatric Association Consensus Development Conference on Antipsychotic Drugs and Obesity and Diabetes call for a more integrated and cooperative approach between primary care physicians and mental health care providers to improve the quality of health care for people with severe mental illness. By routinely performing physical health monitoring, referrals, and/or treatment for patients with schizophrenia and other forms of severe mental illness, mental health care providers can take a lead role in transforming the current system of fragmented mental and physical health services into a system focused on early intervention, wellness, and recovery.
C1 Yale Univ, Sch Med, Dept Psychiat, West Haven, CT 06516 USA.
   Vet Affairs Connecticut Healthcare Syst, West Haven, CT USA.
C3 Yale University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Connecticut Healthcare System
RP Sernyak, MJ (corresponding author), Yale Univ, Sch Med, Dept Psychiat, 950 Campbell Ave, West Haven, CT 06516 USA.
EM michael.sernyak@yale.edu
CR Allison DB, 1999, J CLIN PSYCHIAT, V60, P215, DOI 10.4088/JCP.v60n0402
   *AM PSYCH ASS, 2006, PSYCHIAT NEWS, V41, P34
   Amer Diabet Assoc, 2004, DIABETES CARE, V27, P596, DOI 10.2337/diacare.27.2.596
   *BAZ CTR MENT HLTH, 2003, PRES COMM OFF PRESCR
   *BRIT ASS PSYCH, 2005, J PSYCHOPHARMACOL S, V19, P118
   BUOTE BJ, 2004, BOSTON GLOBE    0118
   Bushe C, 2004, BRIT J PSYCHIAT, V184, pS67, DOI 10.1192/bjp.184.47.s67
   Carney CP, 1998, PSYCHIATR SERV, V49, P1594, DOI 10.1176/ps.49.12.1594
   Cohn TA, 2006, CAN J PSYCHIAT, V51, P492, DOI 10.1177/070674370605100804
   Colton Craig W, 2006, Prev Chronic Dis, V3, pA42
   Cuffel B, 2006, 159 ANN M AM PSYCH A
   Dixon L, 1999, J NERV MENT DIS, V187, P496, DOI 10.1097/00005053-199908000-00006
   Druss BG, 2001, ARCH GEN PSYCHIAT, V58, P861, DOI 10.1001/archpsyc.58.9.861
   Fagiolini A, 2003, AM J PSYCHIAT, V160, P112, DOI 10.1176/appi.ajp.160.1.112
   Field M.J., 1992, Guidelines for clinical practice: from development to use
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Haffner SM, 1998, NEW ENGL J MED, V339, P229, DOI 10.1056/NEJM199807233390404
   Joukamaa M, 2001, BRIT J PSYCHIAT, V179, P498, DOI 10.1192/bjp.179.6.498
   Kane JM, 2004, J CLIN PSYCHIAT, V65, P1447, DOI 10.4088/JCP.v65n1102
   Koyanagi C., 2004, Get it together. How to integrate physical and mental health care for people with serious mental disorders: a report by the Bazelon Center for Mental Health Law
   Lambert Timothy J R, 2003, Med J Aust, V178, pS67
   Marder SR, 2004, AM J PSYCHIAT, V161, P1334, DOI 10.1176/appi.ajp.161.8.1334
   Miller CL, 2003, PSYCHIAT SERV, V54, P1158, DOI 10.1176/appi.ps.54.8.1158
   Newcomer JW, 2007, J CLIN PSYCHIAT, V68, P8
   Newcomer John W, 2004, J Clin Psychopharmacol, V24, pS1, DOI 10.1097/01.jcp.0000142281.85207.d5
   *NPC, 2004, DIS MAN SCHIZ
   Ösby U, 2000, BRIT MED J, V321, P483, DOI 10.1136/bmj.321.7259.483
   Richardson CR, 2005, PSYCHIAT SERV, V56, P324, DOI 10.1176/appi.ps.56.3.324
   Rosack J., 2003, Psychiatric News, V38, P1
   Sernyak MJ, 2002, AM J PSYCHIAT, V159, P561, DOI 10.1176/appi.ajp.159.4.561
   SHARFSTEIN S, 2006, PSYCHIAT NEWS, V38, P3
   WILLIE GS, 2001, CLIN DIABETES, V19, P170
NR 32
TC 31
Z9 33
U1 0
U2 8
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PY 2007
VL 68
SU 4
BP 14
EP 18
PG 5
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S); Conference Proceedings Citation Index - Social Science &amp; Humanities (CPCI-SSH)
SC Psychology; Psychiatry
GA 167PD
UT WOS:000246462700003
PM 17539695
DA 2025-06-11
ER

PT J
AU Zha, BS
   Wan, XS
   Zhang, XX
   Zha, WB
   Zhou, J
   Wabitsch, M
   Wang, GJ
   Lyall, V
   Hylemon, PB
   Zhou, HP
AF Zha, Beth S.
   Wan, Xiaoshan
   Zhang, Xiaoxuan
   Zha, Weibin
   Zhou, Jun
   Wabitsch, Martin
   Wang, Guangji
   Lyall, Vijay
   Hylemon, Phillip B.
   Zhou, Huiping
TI HIV Protease Inhibitors Disrupt Lipid Metabolism by Activating
   Endoplasmic Reticulum Stress and Inhibiting Autophagy Activity in
   Adipocytes
SO PLOS ONE
LA English
DT Article
ID ADIPOSE-TISSUE; INFECTED PATIENTS; GENE-EXPRESSION; IN-VITRO; INSULIN
   SENSITIVITY; ANTIRETROVIRAL TREATMENT; ADIPOKINE SECRETION; CELLULAR
   MECHANISMS; HUMAN PREADIPOCYTES; P-GLYCOPROTEIN
AB Background: HIV protease inhibitors (PI) are core components of Highly Active Antiretroviral Therapy (HAART), the most effective treatment for HIV infection currently available. However, HIV PIs have now been linked to lipodystrophy and dyslipidemia, which are major risk factors for cardiovascular disease and metabolic syndrome. Our previous studies have shown that HIV PIs activate endoplasmic reticulum (ER) stress and disrupt lipid metabolism in hepatocytes and macrophages. Yet, little is known on how HIV PIs disrupt lipid metabolism in adipocytes, a major cell type involved in the pathogenesis of metabolic syndrome.
   Methodology and Principal Findings: Cultured and primary mouse adipocytes and human adipocytes were used to examine the effect of frequently used HIV PIs in the clinic, lopinavir/ritonavir, on adipocyte differentiation and further identify the underlying molecular mechanism of HIV PI-induced dysregulation of lipid metabolism in adipocytes. The results indicated that lopinavir alone or in combination with ritonavir, significantly activated the ER stress response, inhibited cell differentiation, and induced cell apoptosis in adipocytes. In addition, HIV PI-induced ER stress was closely linked to inhibition of autophagy activity. We also identified through the use of primary adipocytes of CHOP-/- mice that CHOP, the major transcriptional factor of the ER stress signaling pathway, is involved in lopinavir/ritonavir-induced inhibition of cell differentiation in adipocytes. In addition, lopinavir/ritonavir-induced ER stress appears to be associated with inhibition of autophagy activity in adipocytes.
   Conclusion and Significance: Activation of ER stress and impairment of autophagy activity are involved in HIV PI-induced dysregulation of lipid metabolism in adipocytes. The key components of ER stress and autophagy signaling pathways are potential therapeutic targets for HIV PI-induced metabolic side effects in HIV patients.
C1 [Zha, Beth S.; Zha, Weibin; Hylemon, Phillip B.; Zhou, Huiping] Virginia Commonwealth Univ, Dept Microbiol & Immunol, Sch Med, Richmond, VA 23298 USA.
   [Wan, Xiaoshan; Zhou, Jun; Zhou, Huiping] Wenzhou Med Coll, Sch Pharm, Wenzhou, Zhejiang, Peoples R China.
   [Zhang, Xiaoxuan; Zha, Weibin; Wang, Guangji] China Pharmaceut Univ, Key Lab Drug Metab & Pharmacokinet, Nanjing, Jiangsu, Peoples R China.
   [Wabitsch, Martin] Univ Ulm, Div Pediat Endocrinol & Diabet, D-89069 Ulm, Germany.
   [Lyall, Vijay] Virginia Commonwealth Univ, Dept Physiol & Biophys, Sch Med, Richmond, VA USA.
   [Hylemon, Phillip B.; Zhou, Huiping] McGuire Vet Affairs Med Ctr, Richmond, VA USA.
C3 Virginia Commonwealth University; Wenzhou Medical University; China
   Pharmaceutical University; Ulm University; Virginia Commonwealth
   University; Hunter Holmes McGuire Veterinary Affairs Medical Center
RP Zhou, HP (corresponding author), Virginia Commonwealth Univ, Dept Microbiol & Immunol, Sch Med, Richmond, VA 23298 USA.
EM hzhou@vcu.edu
RI Zha, Beth Shoshana/JXM-0505-2024; Zhou, Huiping/H-6875-2019
FU National Institutes of Health [R21 AI068432, R01 AT004148,
   1F30DK085856-02]; VA Merit Award [1I01BX001390]; VCU Presidential
   Research Incentive Program Award; School of Medicine; VCU; National
   Science Foundation of China [81070245, 81270489]; VCU Department of
   Anatomy and Neurobiology Microscopy Facility; NIH-NINDS [5P30NS047463];
   NIH [DC011569]; NIH-NINDS Center [5P30NS047463]
FX The study was supported by: National Institutes of Health grants to
   Huiping Zhou (R21 AI068432, R01 AT004148) and to Beth Zha
   (1F30DK085856-02); and VA Merit Award (1I01BX001390 to Huiping Zhou).
   This study is partially supported by the VCU Presidential Research
   Incentive Program Award (Huiping Zhou), School of Medicine, VCU Bridge
   funding (Huiping Zhou) and National Science Foundation of China (Grant
   81070245 and 81270489 to Huiping Zhou). Microscopy was performed at the
   VCU Department of Anatomy and Neurobiology Microscopy Facility,
   supported, in part, with funding from NIH-NINDS Center core grant
   (5P30NS047463). The study was also supported by NIH DC011569 to Vijay
   Lyall and NIH-NINDS Center Core grant (5P30NS047463). The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
CR Ahima RS, 2000, TRENDS ENDOCRIN MET, V11, P327, DOI 10.1016/S1043-2760(00)00301-5
   Bays HE, 2008, INT J CLIN PRACT, V62, P1474, DOI 10.1111/j.1742-1241.2008.01848.x
   Belfort R, 2010, J CLIN ENDOCR METAB, V95, P829, DOI 10.1210/jc.2009-1487
   Bjorkoy G, 2009, METHOD ENZYMOL, V452, P181, DOI 10.1016/S0076-6879(08)03612-4
   Bobbert T, 2009, CLIN ENDOCRINOL, V71, P507, DOI 10.1111/j.1365-2265.2008.03519.x
   Calza L, 2008, INT J STD AIDS, V19, P541, DOI 10.1258/ijsa.2008.007322
   Capel E, 2012, ANTIVIR THER, V17, P549, DOI 10.3851/IMP1988
   Carr A, 1998, NEW ENGL J MED, V339, P1296, DOI 10.1056/NEJM199810293391806
   Cianflone K, 2006, ANTIVIR THER, V11, P681
   Czaja MJ, 2011, AM J PHYSIOL-CELL PH, V298, pC973
   Djedaini M, 2009, BIOCHEM BIOPH RES CO, V386, P96, DOI 10.1016/j.bbrc.2009.05.148
   Dong HQ, 2011, TRENDS ENDOCRIN MET, V22, P234, DOI 10.1016/j.tem.2011.02.003
   Elens L, 2009, PHARMACOGENOMICS, V10, P1589, DOI [10.2217/pgs.09.88, 10.2217/PGS.09.88]
   Estrada Vicente, 2008, Enferm Infecc Microbiol Clin, V26 Suppl 10, P10
   Fiorenza CG, 2011, NAT REV ENDOCRINOL, V7, P137, DOI 10.1038/nrendo.2010.199
   Flint OP, 2009, TOXICOL PATHOL, V37, P65, DOI 10.1177/0192623308327119
   Ford J, 2004, J ANTIMICROB CHEMOTH, V54, P982, DOI 10.1093/jac/dkh487
   Friis-Moller N, 2007, NEW ENGL J MED, V356, P1723, DOI 10.1056/NEJMoa062744
   Gagnon A, 1998, LANCET, V352, P1032, DOI 10.1016/S0140-6736(05)60074-8
   Gallego-Escuredo JM, 2010, CURR HIV RES, V8, P545, DOI 10.2174/157016210793499222
   Ganley IG, 2011, MOL CELL, V42, P731, DOI 10.1016/j.molcel.2011.04.024
   Gibellini L, 2012, AIDS, V26, P2017, DOI 10.1097/QAD.0b013e328359b8be
   Gills J, 2007, CLIN CANCER RES, V13, P5183, DOI 10.1158/1078-0432.CCR-07-0161
   Giralt M, 2011, BEST PRACT RES CL EN, V25, P487, DOI 10.1016/j.beem.2010.12.001
   Goudeau H, 1998, DEV BIOL, V193, P225, DOI 10.1006/dbio.1997.8799
   GREENSPAN P, 1985, J CELL BIOL, V100, P965, DOI 10.1083/jcb.100.3.965
   Grigem S, 2005, HORM METAB RES, V37, P602, DOI 10.1055/s-2005-870526
   Guallar JP, 2008, AIDS, V22, P575, DOI 10.1097/QAD.0b013e3282f56b40
   Gustafson B, 2010, J ATHEROSCLER THROMB, V17, P332, DOI 10.5551/jat.3939
   Hennessy M, 2004, ANTIVIR THER, V9, P115
   Hennessy M, 2003, ANTIVIR THER, V8, P191
   Jackson A, 2011, J ANTIMICROB CHEMOTH, V66, P635, DOI 10.1093/jac/dkq468
   Jones SP, 2008, AIDS, V22, P1293, DOI 10.1097/QAD.0b013e3283021a4f
   Jones SP, 2005, ANTIVIR THER, V10, P207
   Kaplowitz N, 2007, SEMIN LIVER DIS, V27, P367, DOI 10.1055/s-2007-991513
   Komiya K, 2010, BIOCHEM BIOPH RES CO, V401, P561, DOI 10.1016/j.bbrc.2010.09.101
   Lafeuillade A, 2004, HIV CLIN TRIALS, V5, P392, DOI 10.1310/Q0TG-0V50-9JML-638U
   Lagathu C, 2005, BIOCHIMIE, V87, P65, DOI 10.1016/j.biochi.2004.12.007
   Lagathu C, 2007, ANTIVIR THER, V12, P489
   Lenhard JM, 2000, ANTIVIR RES, V47, P121, DOI 10.1016/S0166-3542(00)00102-9
   Lin JH, 2008, ANNU REV PATHOL-MECH, V3, P399, DOI 10.1146/annurev.pathmechdis.3.121806.151434
   Lionetti L, 2009, NUTR METAB CARDIOVAS, V19, P146, DOI 10.1016/j.numecd.2008.10.010
   McLean K, 2009, GYNECOL ONCOL, V112, P623, DOI 10.1016/j.ygyno.2008.11.028
   Meaden ER, 2002, J ANTIMICROB CHEMOTH, V50, P583, DOI 10.1093/jac/dkf161
   Mello AF, 2011, J ANTIMICROB CHEMOTH, V66, P1573, DOI 10.1093/jac/dkr151
   Noor MA, 2006, AIDS, V20, P1813, DOI 10.1097/01.aids.0000244200.11006.55
   Ogata M, 2006, MOL CELL BIOL, V26, P9220, DOI 10.1128/MCB.01453-06
   Or-Tzadikario S, 2010, TISSUE ENG PART C-ME, V16, P1167, DOI [10.1089/ten.tec.2009.0755, 10.1089/ten.TEC.2009.0755]
   Pacenti M, 2006, AIDS, V20, P1691, DOI 10.1097/01.aids.0000242815.80462.5a
   Pankiv S, 2007, J BIOL CHEM, V282, P24131, DOI 10.1074/jbc.M702824200
   Parker RA, 2005, MOL PHARMACOL, V67, P1909, DOI 10.1124/mol.104.010165
   Rasouli N, 2008, J CLIN ENDOCR METAB, V93, pS64, DOI 10.1210/jc.2008-1613
   Rhee MS, 2010, J CLIN PHARMACOL, V50, P392, DOI 10.1177/0091270009339739
   Robenek H., 2010, Journal of Lipids, V2011, P1
   Roberts Esteban A., 2008, V445, P111, DOI 10.1007/978-1-59745-157-4_6
   Singh R, 2009, J CLIN INVEST, V119, P3329, DOI 10.1172/JCI39228
   Singh R, 2009, NATURE, V458, P1131, DOI 10.1038/nature07976
   Sriburi R, 2004, J CELL BIOL, V167, P35, DOI 10.1083/jcb.200406136
   Sriburi R, 2007, J BIOL CHEM, V282, P7024, DOI 10.1074/jbc.M609490200
   Torres M, 2011, PLOS ONE, V5
   Toth Ambrus, 2007, Cardiovascular & Hematological Disorders - Drug Targets, V7, P205, DOI 10.2174/187152907781745260
   Vernochet C, 2005, J BIOL CHEM, V280, P2238, DOI 10.1074/jbc.M408687200
   Virtue S, 2010, BBA-MOL CELL BIOL L, V1801, P338, DOI 10.1016/j.bbalip.2009.12.006
   Wabitsch M, 2001, INT J OBESITY, V25, P8, DOI 10.1038/sj.ijo.0801520
   Walther TC, 2009, BBA-MOL CELL BIOL L, V1791, P459, DOI 10.1016/j.bbalip.2008.10.009
   Wang Y, 2012, HEPATOLOGY
   Williams K, 2004, BIOCHEM PHARMACOL, V67, P255, DOI 10.1016/j.bcp.2003.08.044
   Wu XD, 2010, GASTROENTEROLOGY, V138, P197, DOI 10.1053/j.gastro.2009.08.054
   Yorimitsu T, 2007, TRENDS CELL BIOL, V17, P279, DOI 10.1016/j.tcb.2007.04.005
   Yoshida H, 2007, FEBS J, V274, P630, DOI 10.1111/j.1742-4658.2007.05639.x
   Yu ZG, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002321
   Zha WB, 2012, CURR DRUG METAB, V13, P1174, DOI 10.2174/138920012802850119
   Zhou HP, 2005, MOL PHARMACOL, V68, P690, DOI 10.1124/mol.105.012898
   Zhou Huiping, 2007, Atherosclerosis, V195, pe134, DOI 10.1016/j.atherosclerosis.2007.04.008
   Zhou HP, 2006, FUTURE LIPIDOL, V1, P163, DOI 10.2217/17460875.1.2.163
   Zhou HP, 2006, AM J PHYSIOL-GASTR L, V291, pG1071, DOI 10.1152/ajpgi.00182.2006
   Zhou J, 2005, CIRCULATION, V111, P1814, DOI 10.1161/01.CIR.0000160864.31351.C1
   Zhou L, 2011, AUTOPHAGY, V6, P1196
   Zhu L, 2010, ANTIVIR THER, V15, P1107, DOI 10.3851/IMP1673
NR 79
TC 62
Z9 67
U1 0
U2 29
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 22
PY 2013
VL 8
IS 3
AR e59514
DI 10.1371/journal.pone.0059514
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 111VQ
UT WOS:000316549400067
PM 23533630
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Romain, AJ
   Avignon, A
   Macioce, V
   Boegner, C
   Attalin, A
   Sultan, A
AF Romain, A. J.
   Avignon, A.
   Macioce, V
   Boegner, C.
   Attalin, A.
   Sultan, A.
TI Patterns of eating behavior in people with severe obesity seeking weight
   loss treatment: An exploratory study
SO APPETITE
LA English
DT Article
DE Eating behavior; Cluster; Depression; Quality of life; Physical
   activity; Emotional eating
ID QUALITY-OF-LIFE; PHYSICAL-ACTIVITY; DEPRESSIVE SYMPTOMS; QUESTIONNAIRE;
   VALIDATION; ASSOCIATION; PHENOTYPES; ADULTS
AB Although subjects with severe obesity need specific interventions, knowledge about their eating behavior, physical and mental health profiles remains insufficient. This cross-sectional study aimed to identify profiles of individuals with severe obesity based on clinical, psychological and eating behavior characteristics. We included 126 participants (103 women; mean age: 47.2 +/- 13.9 years; mean BMI: 41.0 +/- 5.7 kg/m(2)). Cluster analyses were performed to identify profiles based on age, waist circumference, eating behavior, depressive symptoms, food-related quality of life and physical activity. Metabolic syndrome components and type 2 diabetes prevalence were compared between the clusters. Three clusters were identified. Cluster 1 labeled struggling with food (48% of the population) had high scores on both emotional eating and uncontrolled eating, low score on comfort with food and they had depressive symptoms. Cluster 2, low loss of eating control (29%), had low scores on emotional eating and uncontrolled eating, and high quality of life in the psychosocial dimension. Cluster 3, pleasure from eating (22%), had the greatest score on comfort with food, the highest physical activity level, and depressive symptoms. In cluster 2, prevalence of type 2 diabetes was higher, although not statistically significant. Otherwise, no differences were found between clusters. Conclusion: Subjects with severe obesity have different profiles, partly explained by their eating behavior, associated with clinical and behavioral patterns. Further studies should confirm this cluster structure and assess how these profiles impact the evolution of obesity and whether they can help to improve the personalization of care programs.
C1 [Romain, A. J.; Avignon, A.; Boegner, C.; Attalin, A.; Sultan, A.] Univ Montpellier, Dept Nutr & Diabet, CHU Montpellier, 371 Ave Doyen Gaston Giraud, F-34295 Montpellier, France.
   [Macioce, V] Univ Montpellier, Clin Res & Epidemiol Unit, CHU Montpellier, 39 Ave Charles Flahault, F-34295 Montpellier, France.
   [Avignon, A.; Attalin, A.] Univ Montpellier, Inst Desbrest Epidemiol & Publ Hlth, INSERM, UMR 1302, Montpellier, France.
   [Sultan, A.] INSERM, U1046, Physiol & Expt Med Heart & Muscles, F-34295 Montpellier, France.
   [Romain, A. J.] Univ Montreal, Fac Med, Sch Kinesiol & Phys Act Sci, Montreal, PQ H3T 1J4, Canada.
   [Romain, A. J.] Montreal Mental Hlth Univ Inst Res Ctr, Montreal, PQ H1N 3V2, Canada.
C3 Universite de Montpellier; CHU de Montpellier; Universite de
   Montpellier; CHU de Montpellier; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite de Montpellier; Universite de
   Montpellier; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite de Montreal
RP Avignon, A (corresponding author), Dept Endocrinol Diabetol Nutr, 371 Ave Doyen Gaston Giraud, F-34295 Montpellier, France.
EM a-avignon@chu-montpellier.fr
RI Romain, Ahmed/AAP-5893-2020
OI Romain, Ahmed Jerome/0000-0003-1690-1375
FU Montpellier University Hospital [AOI 9110/2013-A00272-43]
FX This study was supported by a grant from Montpellier University Hospital
   (AOI 9110/2013-A00272-43).
CR Acosta A, 2021, OBESITY, V29, P662, DOI 10.1002/oby.23120
   Andrade AM, 2010, PATIENT EDUC COUNS, V79, P320, DOI 10.1016/j.pec.2010.01.006
   Annesi JJ, 2016, EAT WEIGHT DISORD-ST, V21, P289, DOI 10.1007/s40519-015-0209-9
   Baillot A, 2018, MENT HEALTH PHYS ACT, V14, P1, DOI 10.1016/j.mhpa.2017.12.004
   Baillot A, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0119017
   Bastin A, 2019, CLIN OBES, V9, DOI 10.1111/cob.12287
   Bouhlal S, 2017, APPETITE, V111, P142, DOI 10.1016/j.appet.2016.12.006
   Brogan A, 2013, PSYCHOL HEALTH, V28, P714, DOI 10.1080/08870446.2012.760033
   Bull FC, 2009, J PHYS ACT HEALTH, V6, P790, DOI 10.1123/jpah.6.6.790
   Carraça EV, 2011, INT J BEHAV NUTR PHY, V8, DOI 10.1186/1479-5868-8-75
   de Lauzon B, 2004, J NUTR, V134, P2372
   Dohle S, 2014, PSYCHOL HEALTH, V29, P1062, DOI 10.1080/08870446.2014.909042
   Fabricatore AN, 2005, OBES SURG, V15, P304, DOI 10.1381/0960892053576578
   Fontaine K R, 2001, Obes Rev, V2, P173, DOI 10.1046/j.1467-789x.2001.00032.x
   FUHRER R, 1989, Psychiatrie and Psychobiologie, V4, P163
   Ghachenn A, 2019, CLIN OBES, V9, DOI 10.1111/cob.12295
   Goldschmidt AB, 2014, INT J EAT DISORDER, V47, P281, DOI 10.1002/eat.22188
   Gruszka W, 2020, EAT WEIGHT DISORD-ST, V25, P283, DOI 10.1007/s40519-018-0578-y
   HOLM S, 1979, SCAND J STAT, V6, P65
   Jepsen R, 2015, J OBES, V2015, DOI 10.1155/2015/314194
   Jepsen R, 2013, HEALTH QUAL LIFE OUT, V11, DOI 10.1186/1477-7525-11-187
   Kivimäki M, 2017, LANCET PUBLIC HEALTH, V2, pE277, DOI 10.1016/S2468-2667(17)30074-9
   Konttinen H, 2010, AM J CLIN NUTR, V92, P1031, DOI 10.3945/ajcn.2010.29732
   Lluch A, 1996, EUR PSYCHIAT, V11, P198, DOI 10.1016/0924-9338(96)88391-X
   Ogden LG, 2012, OBESITY, V20, P2039, DOI 10.1038/oby.2012.79
   Pentikäinen S, 2018, APPETITE, V120, P212, DOI 10.1016/j.appet.2017.09.001
   Romain AJ, 2018, J AFFECT DISORDERS, V225, P381, DOI 10.1016/j.jad.2017.08.065
   Twells Laurie K, 2014, CMAJ Open, V2, pE18, DOI 10.9778/cmajo.20130016
   van de Laar FA, 2006, DIABETIC MED, V23, P788, DOI 10.1111/j.1464-5491.2006.01885.x
   van Strien T, 2007, HEALTH PSYCHOL, V26, P105, DOI 10.1037/0278-6133.26.1.105
   van Strien T, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1000-x
   VANSTRIEN T, 1986, INT J EAT DISORDER, V5, P295, DOI 10.1002/1098-108X(198602)5:2<295::AID-EAT2260050209>3.0.CO;2-T
   Vittengl JR, 2018, PSYCHIAT RES, V264, P254, DOI 10.1016/j.psychres.2018.03.023
   WEISSMAN MM, 1977, AM J EPIDEMIOL, V106, P203, DOI 10.1093/oxfordjournals.aje.a112455
   Ziegler O, 2005, DIABETES METAB, V31, P273, DOI 10.1016/S1262-3636(07)70194-5
NR 35
TC 5
Z9 6
U1 1
U2 5
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0195-6663
EI 1095-8304
J9 APPETITE
JI Appetite
PD FEB 1
PY 2022
VL 169
AR 105797
DI 10.1016/j.appet.2021.105797
EA JAN 2022
PG 7
WC Behavioral Sciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Nutrition & Dietetics
GA 2T5YP
UT WOS:000822550200003
PM 34752827
OA Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Protsenko, M
   Kerkelä, M
   Miettunen, J
   Auvinen, J
   Järvelin, MR
   Jones, PB
   Gissler, M
   Veijola, J
AF Protsenko, Maria
   Kerkela, Martta
   Miettunen, Jouko
   Auvinen, Juha
   Jarvelin, Marjo-Riitta
   Jones, Peter B.
   Gissler, Mika
   Veijola, Juha
TI Cardiometabolic Disorders in the Offspring of Parents With Severe Mental
   Illness
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE schizophrenia; bipolar disorder; depression; metabolic syndrome;
   offspring; cohort study; CI = confidence interval; CRHC = Care Register
   for Health Care; HR = hazard ratio; NFBC1966=Northern Finland Birth
   Cohort 1966; SMI = severe mental illness
ID MAJOR DEPRESSIVE DISORDER; ALCOHOL-CONSUMPTION; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; RISK; SCHIZOPHRENIA; DISEASE; OBESITY; ASSOCIATIONS;
   METAANALYSIS
AB Objective The elevated prevalence of cardiometabolic disorders is consistently reported in patients with severe mental illness (SMI). We explored the association between parental SMI and offspring cardiometabolic morbidity. Our hypothesis was that offspring of people with SMI have increased morbidity risk. Method The Northern Finland Birth Cohort 1966 is a study of offspring whose date of birth was expected in 1966. The follow-up lasted until 2015 (49 years). The final study sample included 11,175 children. We used parental SMI as the exposure in the study. The following cardiometabolic disorders were used as outcome measures: diabetes mellitus, hypertension, hyperlipidemia, coronary artery disease, obesity, and cerebrovascular disorders. Results There were 139 (14.7%; hazard ratios [HR] = 1.63; 95% confidence interval [CI] = 1.36-1.94) children of parents with SMI who developed cardiometabolic disorder during follow-up and 957 (9.4%) in the comparison cohort. Statistically significant HRs were found in males (HR = 1.95; 95% CI =1.56-2.44), but not in females (HR = 1.29; 95% CI = 0.96-1.73). Conclusions Having a cardiometabolic disorder was associated with male offspring of parents with SMI. Our findings suggest that there is an elevated risk of coronary artery disease, hyperlipidemia, obesity, and hypertension in the male offspring of parents with SMI. Our results suggest that the somatic health of offspring of parents with SMI should also be considered in addition to their mental health in clinical practice.
C1 [Protsenko, Maria; Kerkela, Martta; Veijola, Juha] Univ Oulu, Dept Psychiat, Oulu, Finland.
   [Miettunen, Jouko; Auvinen, Juha; Jarvelin, Marjo-Riitta] Univ Oulu, Res Unit Clin Neurosci, Oulu, Finland.
   [Miettunen, Jouko; Auvinen, Juha; Jarvelin, Marjo-Riitta] Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland.
   [Miettunen, Jouko; Veijola, Juha] Oulu Univ Hosp, Med Res Ctr Oulu, Oulu, Finland.
   [Gissler, Mika] Finnish Inst Hlth & Welf, Informat Serv Dept, Helsinki, Finland.
   [Gissler, Mika] Univ Turku, Res Ctr Child Psychiat, Turku, Finland.
   [Gissler, Mika] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden.
   [Veijola, Juha] Univ Hosp Oulu, Dept Psychiat, Oulu, Finland.
   [Jones, Peter B.] Univ Cambridge, Dept Psychiat, Cambridge, England.
C3 University of Oulu; University of Oulu; University of Oulu; University
   of Oulu; University of Turku; Karolinska Institutet; University of
   Cambridge
RP Protsenko, M (corresponding author), Univ Oulu, Peltolantie 17, Oulu 90014, Finland.
EM maria.protsenko@oulu.fi; martta.kerkela@oulu.fi;
   jouko.miettunen@oulu.fi; juha.auvinen@oulu.fi;
   m.jarvelin@imperial.ac.uk; pbj21@cam.ac.uk; mika.gissler@thl.fi;
   juha.veijola@oulu.fi
RI Miettunen, Jouko/AAC-4334-2019; Jones, Peter/AGE-5945-2022
OI Jones, Peter Brian/0000-0002-0387-880X; Kerkela,
   Martta/0000-0002-1181-2632; Protsenko, Maria/0000-0001-5540-9039
FU University of Oulu [24000692]; Oulu University Hospital [24301140]; ERDF
   European Regional Development Fund [539/2010 A31592]
FX The authors declare that they have no conflict of interest. The Northern
   Finland Birth Cohort 1966 received financial support from University of
   Oulu Grant No. 24000692, Oulu University Hospital Grant No. 24301140,
   and ERDF European Regional Development Fund Grant No. 539/2010 A31592.
CR Andreassen OA, 2013, AM J HUM GENET, V92, P197, DOI 10.1016/j.ajhg.2013.01.001
   Anjum S, 2019, DIABETES METAB SYND, V13, P12, DOI 10.1016/j.dsx.2018.08.013
   [Anonymous], 2019, NFBC1966
   Benros ME, 2014, AM J PSYCHIAT, V171, P218, DOI 10.1176/appi.ajp.2013.13010086
   Chen DC, 2016, PSYCHOL MED, V46, P3219, DOI 10.1017/S0033291716001902
   Christakis NA, 2007, NEW ENGL J MED, V357, P370, DOI 10.1056/NEJMsa066082
   Correll CU, 2014, JAMA PSYCHIAT, V71, P1350, DOI 10.1001/jamapsychiatry.2014.1314
   Countryman AJ, 2013, ANN BEHAV MED, V45, P121, DOI 10.1007/s12160-012-9428-8
   de Wit L, 2010, PSYCHIAT RES, V178, P230, DOI 10.1016/j.psychres.2009.04.015
   Donofrio B, 2014, CHILD DEV PERSPECT, V8, P151, DOI 10.1111/cdep.12078
   Du D, 2017, EUR J PREV CARDIOL, V24, P1967, DOI 10.1177/2047487317724008
   Fedewa MV, 2014, PEDIATRICS, V133, pE163, DOI 10.1542/peds.2013-2718
   Gastaldelli A, 2010, CURR PHARM DESIGN, V16, P2526, DOI 10.2174/138161210792062858
   Gough Stephen C L, 2005, J Psychopharmacol, V19, P47, DOI 10.1177/0269881105058380
   Horikoshi M, 2013, NAT GENET, V45, P76, DOI 10.1038/ng.2477
   Koponen H, 2008, ACTA PSYCHIAT SCAND, V117, P337, DOI 10.1111/j.1600-0447.2008.01154.x
   Laursen TM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0067133
   Laursen TM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024597
   Levinson DF, 2014, BIOL PSYCHIAT, V76, P510, DOI 10.1016/j.biopsych.2014.07.029
   Liu YL, 2013, BMC MED GENOMICS, V6, DOI 10.1186/1755-8794-6-S1-S17
   Maudsley H., 1886, PATHOLOGY MIND
   Möller-Leimkühler AM, 2012, EUR ARCH PSY CLIN N, V262, P157, DOI 10.1007/s00406-011-0215-5
   Moilanen K, 2003, SOC PSYCH PSYCH EPID, V38, P305, DOI 10.1007/s00127-003-0638-z
   Morden NE, 2012, GEN HOSP PSYCHIAT, V34, P368, DOI 10.1016/j.genhosppsych.2012.02.009
   Mothi SS, 2015, SCHIZOPHR RES, V165, P103, DOI 10.1016/j.schres.2015.03.034
   Mukamal KJ, 2016, ALCOHOL CLIN EXP RES, V40, P2283, DOI 10.1111/acer.13231
   MUKHERJEE S, 1989, LANCET, V1, P495
   Nordentoft M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055176
   Padmanabhan JL, 2016, J PSYCHIATR RES, V77, P52, DOI 10.1016/j.jpsychires.2016.02.015
   Postolache TT, 2019, AM J MED GENET B, V180, P186, DOI 10.1002/ajmg.b.32712
   Rasic D, 2014, SCHIZOPHRENIA BULL, V40, P28, DOI 10.1093/schbul/sbt114
   Robson D, 2007, INT J NURS STUD, V44, P457, DOI 10.1016/j.ijnurstu.2006.07.013
   Ruetsch O, 2005, ENCEPHALE, V31, P507
   Rustad JK, 2011, PSYCHONEUROENDOCRINO, V36, P1276, DOI 10.1016/j.psyneuen.2011.03.005
   Smith C.J., 2004, Child and Family Social Work, V9, P3, DOI [DOI 10.1111/J.1365-2206.2004.00312.X, 10.1111/j.1365-2206.2004.00312.x]
   Stein A, 2014, LANCET, V384, P1800, DOI 10.1016/S0140-6736(14)61277-0
   Sturm R, 2002, HEALTH AFFAIR, V21, P245, DOI 10.1377/hlthaff.21.2.245
   Sund R, 2012, SCAND J PUBLIC HEALT, V40, P505, DOI 10.1177/1403494812456637
   Tammelin T, 2003, AM J PREV MED, V24, P22, DOI 10.1016/S0749-3797(02)00575-5
   van Welie H, 2013, SCHIZOPHR RES, V143, P354, DOI 10.1016/j.schres.2012.11.011
   Wandell P, 2014, J PSYCHOSOM RES, V77, P169, DOI 10.1016/j.jpsychores.2014.06.012
   Yang JL, 2012, PSYCHIAT RES, V198, P183, DOI 10.1016/j.psychres.2011.12.014
NR 42
TC 2
Z9 2
U1 2
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JAN
PY 2022
VL 84
IS 1
BP 2
EP 9
DI 10.1097/PSY.0000000000001022
PG 8
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA XP2YK
UT WOS:000730736200006
PM 34913885
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Chiu, S
   Woodbury-Fariña, MA
   Shad, MU
   Husni, M
   Copen, J
   Bureau, Y
   Cernovsky, Z
   Hou, JJ
   Raheb, H
   Terpstra, K
   Sanchez, V
   Hategan, A
   Kaushal, M
   Campbell, R
AF Chiu, Simon
   Woodbury-Farina, Michel A.
   Shad, Mujeeb U.
   Husni, Mariwan
   Copen, John
   Bureau, Yves
   Cernovsky, Zack
   Hou, J. Jurui
   Raheb, Hana
   Terpstra, Kristen
   Sanchez, Veronica
   Hategan, Ana
   Kaushal, Mike
   Campbell, Robbie
CA St Joseph Hlth Care
TI The Role of Nutrient-Based Epigenetic Changes in Buffering Against
   Stress, Aging, and Alzheimer's Disease
SO PSYCHIATRIC CLINICS OF NORTH AMERICA
LA English
DT Article
DE Alzheimer dementia; Cognition; Stress; Epigenetics diet; Nutraceuticals
ID MILD COGNITIVE IMPAIRMENT; SUPPLEMENTATION IMPROVES MEMORY;
   RISK-FACTORS; MEDITERRANEAN DIET; DNA METHYLATION; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; GLUCOCORTICOID-RECEPTOR; HISTONE ACETYLATION;
   ADENOSINE RECEPTORS
AB Converging evidence identifies stress-related disorders as putative risk factors for Alzheimer Disease (AD). This article reviews evidence on the complex interplay of stress, aging, and genes-epigenetics interactions. The recent classification of AD into preclinical, mild cognitive impairment, and AD offers a window for intervention to prevent, delay, or modify the course of AD. Evidence in support of the cognitive effects of epigenetics-based diet, and nutraceuticals is reviewed. A proactive epigenetics diet and nutraceuticals program holds promise as potential buffer against the negative impact of aging and stress responses on cognition, and can optimize vascular, metabolic, and brain health in the community.
C1 [Chiu, Simon; Campbell, Robbie] Univ Western Ontario, Schulich Sch Med & Dent, Dept Psychiat, London, ON N6G 4X8, Canada.
   [Woodbury-Farina, Michel A.] Univ Puerto Rico, Sch Med, Dept Psychiat, San Juan, PR 00918 USA.
   [Shad, Mujeeb U.] Oregon Hlth & Sci Univ, Dept Psychiat, Portland, OR 97239 USA.
   [Husni, Mariwan] Lakehead Univ, Northern Ontario Med Sch, Thunder Bay, ON P7B 5E1, Canada.
   [Husni, Mariwan] Univ London Imperial Coll Sci Technol & Med, Fac Med, London SW7 2AZ, England.
   [Copen, John] Vancouver Isl Hlth Author, Dept Psychiat, Victoria, BC, Canada.
   [Copen, John] Univ Victoria, Isl Med Program, Univ British Columbia Victoria Med Campus, Victoria, BC V8N 1M5, Canada.
   [Bureau, Yves] Univ Western Ontario, Schulich Sch Med & Dent, Dept Med Biophys, London, ON N6G 4X8, Canada.
   [Hou, J. Jurui; Raheb, Hana] St Joseph Hlth Care, Lawson Hlth Res Inst, Epigenet Res Grp, London, ON N6A 4V2, Canada.
   [Terpstra, Kristen] Univ Toronto, Fac Nursing, Lawrence S Bloomberg, Accelerated BScN Nursing Program, Toronto, ON M5T 1P8, Canada.
   [Sanchez, Veronica] McGill Univ, Meakins Christie Labs, Montreal, PQ H2X 2P2, Canada.
   [Hategan, Ana; Kaushal, Mike] McMaster Univ Hlth Sci, St Josephs Healthcare Hamilton, Geriatr Psychiat Div, Hamilton, ON L8N 3K7, Canada.
C3 Western University (University of Western Ontario); University of Puerto
   Rico; University of Puerto Rico Medical Sciences Campus; Oregon Health &
   Science University; Lakehead University; Imperial College London;
   Vancouver Island Health Authority; University of Victoria; Western
   University (University of Western Ontario); Western University
   (University of Western Ontario); University Western Ontario Hospital;
   University of Toronto; McGill University; McMaster University; McMaster
   University Hospital
RP Chiu, S (corresponding author), Reg Mental Hlth Care London, 850 Highbury Ave, London, ON N6A 4H1, Canada.
EM schiu3207@rogers.com
RI Shad, Mujeeb/GRY-0012-2022
OI Shad, Mujeeb/0000-0002-5136-9452
CR Adwan L, 2013, PHARMACOL THERAPEUT, V139, P41, DOI 10.1016/j.pharmthera.2013.03.010
   Agis-Balboa RC, 2013, J ALZHEIMERS DIS, V33, P35, DOI 10.3233/JAD-2012-121009
   Akbarian S, 2013, JAMA NEUROL, V70, P711, DOI 10.1001/jamaneurol.2013.1459
   Alagiakrishnan K, 2013, DISCOV MED, V16, P277
   [Anonymous], 2014, PUBLIC HLTH NUTR
   Arab L, 2013, ADV NUTR, V4, P115, DOI 10.3945/an.112.002717
   Arab L, 2011, J ALZHEIMERS DIS, V27, P553, DOI 10.3233/JAD-2011-110431
   Barrachina M, 2009, J NEUROPATH EXP NEUR, V68, P880, DOI 10.1097/NEN.0b013e3181af2e46
   Bauer ME, 2010, NEUROIMMUNOMODULAT, V17, P192, DOI 10.1159/000258721
   Baum L, 2008, J CLIN PSYCHOPHARM, V28, P110, DOI 10.1097/jcp.0b013e318160862c
   Bekkering P, 2013, EXPERT REV CLIN IMMU, V9, P1031, DOI 10.1586/1744666X.2013.848793
   Berger SL, 2009, GENE DEV, V23, P781, DOI 10.1101/gad.1787609
   Berr C, 2009, DEMENT GERIATR COGN, V28, P357, DOI 10.1159/000253483
   Bihaqi SW, 2012, CURR ALZHEIMER RES, V9, P574
   Binnewijzend MAA, 2013, RADIOLOGY, V267, P221, DOI 10.1148/radiol.12120928
   Bookheimer SY, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/946298
   Brondino N, 2014, SCI WORLD J, DOI 10.1155/2014/174282
   Butterfield DA, 2014, BBA-MOL BASIS DIS, V1842, P1693, DOI 10.1016/j.bbadis.2014.06.010
   Cacciapuoti F, 2013, J THROMB THROMBOLYS, V36, P258, DOI 10.1007/s11239-012-0856-x
   Calabrese EJ, 2002, HUM EXP TOXICOL, V21, P91, DOI 10.1191/0960327102ht217oa
   Campbell NL, 2013, CLIN GERIATR MED, V29, P873, DOI 10.1016/j.cger.2013.07.009
   Cederholm T, 2013, ADV NUTR, V4, P672, DOI 10.3945/an.113.004556
   Chen ZC, 2013, PROG NEUROBIOL, V108, P21, DOI 10.1016/j.pneurobio.2013.06.004
   Cherniack EP, 2012, BRIT J NUTR, V108, P794, DOI 10.1017/S0007114512000669
   Chin D, 2013, CURR MED CHEM, V20, P3955
   Chiu S, AM PSYCH ASS ANN M P
   Chiu Simon, 2013, J Complement Integr Med, V10, DOI 10.1515/jcim-2013-0020
   Choi SE, 2013, MOL CELLS, V36, P385, DOI 10.1007/s10059-013-0297-1
   Cimini A, 2013, J CELL BIOCHEM, V114, P2209, DOI 10.1002/jcb.24548
   Cohen A. D., 2014, NEUROBIOL DIS
   Conreas D, 2014, OXID MED CELL LONGEV, V2014, P1
   Coppedè F, 2014, FRONT GENET, V5, DOI 10.3389/fgene.2014.00220
   Costanza A, 2011, NEUROPATH APPL NEURO, V37, P570, DOI 10.1111/j.1365-2990.2011.01186.x
   Costenla AR, 2010, J ALZHEIMERS DIS, V20, pS25, DOI 10.3233/JAD-2010-091384
   De Felice FG, 2014, ALZHEIMERS DEMENT, V10, pS26, DOI 10.1016/j.jalz.2013.12.004
   de Kloet ER, 2013, EUR J PHARMACOL, V719, P53, DOI 10.1016/j.ejphar.2013.04.053
   Desideri G, 2012, HYPERTENSION, V60, P794, DOI 10.1161/HYPERTENSIONAHA.112.193060
   Devore EE, 2012, ANN NEUROL, V72, P135, DOI 10.1002/ana.23594
   Diniz BS, 2013, BRIT J PSYCHIAT, V202, P329, DOI 10.1192/bjp.bp.112.118307
   Elmenhorst D, 2012, J NUCL MED, V53, P1723, DOI 10.2967/jnumed.112.105114
   Féart C, 2013, P NUTR SOC, V72, P140, DOI 10.1017/S0029665112002959
   Fleminger S, 2003, J NEUROL NEUROSUR PS, V74, P857, DOI 10.1136/jnnp.74.7.857
   Freiherr J, 2013, CNS DRUGS, V27, P505, DOI 10.1007/s40263-013-0076-8
   Frisardi V, 2010, J ALZHEIMERS DIS, V22, P715, DOI 10.3233/JAD-2010-100942
   Frisoni GB, 2013, NEUROLOGY, V81, P487, DOI 10.1212/WNL.0b013e31829d86e8
   Fuso A, 2011, NEUROBIOL AGING, V32, P1192, DOI 10.1016/j.neurobiolaging.2011.01.012
   Ganguly R, 2012, MOL NUTR FOOD RES, V56, P1090, DOI 10.1002/mnfr.201100700
   Geuze E, 2005, MOL PSYCHIATR, V10, P160, DOI 10.1038/sj.mp.4001579
   Golier JA, 2006, ANN NY ACAD SCI, V1071, P54, DOI 10.1196/annals.1364.006
   Govindarajan N, 2013, EMBO MOL MED, V5, P52, DOI 10.1002/emmm.201201923
   Gräff J, 2012, NATURE, V483, P222, DOI 10.1038/nature10849
   Granzotto A, 2014, FRONT AGING NEUROSCI, V6, DOI 10.3389/fnagi.2014.00095
   Greenberg MS, 2014, ALZHEIMERS DEMENT, V10, pS155, DOI 10.1016/j.jalz.2014.04.008
   Griffiths BB, 2014, NEUROSCIENCE, V275, P420, DOI 10.1016/j.neuroscience.2014.06.041
   Guan J.S., 2014, Experimental neurology
   Hardy TM, 2011, EPIGENOMICS-UK, V3, P503, DOI [10.2217/EPI.11.71, 10.2217/epi.11.71]
   Heo JH, 2008, EUR J NEUROL, V15, P865, DOI 10.1111/j.1468-1331.2008.02157.x
   Heo JH, 2011, J GINSENG RES, V35, P457, DOI 10.5142/jgr.2011.35.4.457
   Hermida AP, 2012, EXPERT REV NEUROTHER, V12, P1339, DOI [10.1586/ern.12.127, 10.1586/ERN.12.127]
   Hooper L, 2012, AM J CLIN NUTR, V95, P740, DOI 10.3945/ajcn.111.023457
   Houston I, 2013, NEUROPSYCHOPHARMACOL, V38, P183, DOI 10.1038/npp.2012.78
   Hubbard BP, 2014, TRENDS PHARMACOL SCI, V35, P146, DOI 10.1016/j.tips.2013.12.004
   Hugo J, 2014, CLIN GERIATR MED, V30, P421, DOI 10.1016/j.cger.2014.04.001
   Iraola-Guzmán S, 2011, CLIN GENET, V80, P1, DOI 10.1111/j.1399-0004.2011.01673.x
   Jarome TJ., 2014, Neurobiol Learn Mem
   Jayasena T, 2013, AGEING RES REV, V12, P867, DOI 10.1016/j.arr.2013.06.003
   Jesky R, 2011, PHYTOTHER RES, V25, P1105, DOI 10.1002/ptr.3388
   Jiang T, 2013, CURR ALZHEIMER RES, V10, P852
   Joëls M, 2012, PHARMACOL REV, V64, P901, DOI 10.1124/pr.112.005892
   Jordan BD, 2013, NAT REV NEUROL, V9, P222, DOI 10.1038/nrneurol.2013.33
   Joseph JA, 2009, J NUTR, V139, p1813S, DOI 10.3945/jn.109.108266
   Kang KA, 2013, INT J ONCOL, V43, P1907, DOI 10.3892/ijo.2013.2129
   Kannappan R, 2011, MOL NEUROBIOL, V44, P142, DOI 10.1007/s12035-011-8168-2
   Kavanagh DH, 2013, MOL PSYCHIATR, V18, P540, DOI 10.1038/mp.2013.13
   Kelleher RJ, 2013, AM J CARDIOVASC DIS, V3, P197
   Kesse-Guyot E, 2013, AM J CLIN NUTR, V97, P369, DOI 10.3945/ajcn.112.047993
   Kim DH, 2014, GENE, V545, P185, DOI 10.1016/j.gene.2014.05.031
   Klengel T, 2014, NEUROPHARMACOLOGY, V80, P115, DOI 10.1016/j.neuropharm.2014.01.013
   Kovacic JC, 2012, MT SINAI J MED, V79, P664, DOI 10.1002/msj.21347
   Krikorian R, 2010, J AGR FOOD CHEM, V58, P3996, DOI 10.1021/jf9029332
   Krikorian R, 2010, BRIT J NUTR, V103, P730, DOI 10.1017/S0007114509992364
   Kugel S, 2014, TRENDS BIOCHEM SCI, V39, P72, DOI 10.1016/j.tibs.2013.12.002
   Lee ST, 2008, ALZ DIS ASSOC DIS, V22, P222, DOI 10.1097/WAD.0b013e31816c92e6
   Leszek J, 2012, J NEUROL SCI, V323, P25, DOI 10.1016/j.jns.2012.09.010
   Loef Martin, 2013, Journal of Nutrition in Gerontology and Geriatrics, V32, P1, DOI 10.1080/21551197.2012.752335
   Lu HY, 2013, FRONT AGING NEUROSCI, V5, DOI 10.3389/fnagi.2013.00085
   Lu J, 2013, P NATL ACAD SCI USA, V110, P10747, DOI 10.1073/pnas.1308950110
   Madugundu GS, 2014, NUCLEIC ACIDS RES, V42, P7450, DOI 10.1093/nar/gku334
   Mahan AL, 2012, TRENDS NEUROSCI, V35, P24, DOI 10.1016/j.tins.2011.06.007
   Mahlknecht U, 2012, ADV EXP MED BIOL, V739, P252, DOI 10.1007/978-1-4614-1704-0_16
   Malouf R, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004514.pub2
   Martin SL, 2013, CURR MED CHEM, V20, P4050
   Martinez-Lapiscina EH, 2013, J NUTR HEALTH AGING, V17, P544, DOI 10.1007/s12603-013-0027-6
   Maruszak A, 2014, J ALZHEIMERS DIS, V38, P11, DOI 10.3233/JAD-131004
   Mastroeni D, 2011, NEUROBIOL AGING, V32, P1161, DOI 10.1016/j.neurobiolaging.2010.08.017
   Mattson Mark P, 2008, TRENDS NEUROSCI, V29, P631
   McEwen BS, 2008, EUR J PHARMACOL, V583, P174, DOI 10.1016/j.ejphar.2007.11.071
   McGowan DP, 2011, PLOS ONE, V6
   McGowan Patrick O, 2013, Front Psychiatry, V4, P110, DOI 10.3389/fpsyt.2013.00110
   McGowan PO, 2009, NAT NEUROSCI, V12, P342, DOI 10.1038/nn.2270
   Medhi B, 2013, NEUROL SCI, V34, P1719, DOI 10.1007/s10072-013-1454-1
   Mifsud KR, 2011, BRAIN BEHAV IMMUN, V25, P1305, DOI 10.1016/j.bbi.2011.06.005
   Mill J, 2011, NEUROBIOL AGING, V32, P1188, DOI 10.1016/j.neurobiolaging.2010.10.021
   Mostofsky E, 2012, CIRC-HEART FAIL, V5, P401, DOI 10.1161/CIRCHEARTFAILURE.112.967299
   Mucalo I, 2012, COLLEGIUM ANTROPOL, V36, P1435
   Müller M, 2014, NEUROBIOL AGING, V35, P152, DOI 10.1016/j.neurobiolaging.2013.07.005
   Munir KM, 2013, AM J PHYSIOL-ENDOC M, V305, pE679, DOI 10.1152/ajpendo.00377.2013
   Nehlig A, 2013, BRIT J CLIN PHARMACO, V75, P716, DOI 10.1111/j.1365-2125.2012.04378.x
   Nguyen AD, 2013, TRENDS ENDOCRIN MET, V24, P597, DOI 10.1016/j.tem.2013.08.003
   Nicolakakis N, 2011, J CEREBR BLOOD F MET, V31, P1354, DOI 10.1038/jcbfm.2011.43
   Nicolia V, 2010, J ALZHEIMERS DIS, V19, P895, DOI 10.3233/JAD-2010-1284
   Noble JM, 2013, NEUROPSYCHOL REV, V23, P273, DOI 10.1007/s11065-013-9239-0
   Noguchi-Shinohara M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0096013
   Nooyens ACJ, 2014, BRIT J NUTR, V111, P715, DOI 10.1017/S0007114513002845
   O'Brien J, 2014, J NUTR HEALTH AGING, V18, P496, DOI 10.1007/s12603-014-0014-6
   Oberlander TF, 2008, EPIGENETICS-US, V3, P97, DOI 10.4161/epi.3.2.6034
   Pace TWW, 2011, BRAIN BEHAV IMMUN, V25, P6, DOI 10.1016/j.bbi.2010.10.003
   Paneni F, 2013, ATHEROSCLEROSIS, V230, P191, DOI 10.1016/j.atherosclerosis.2013.07.003
   Panickar Kiran S., 2013, Central Nervous System Agents in Medicinal Chemistry, V13, P13
   Pasinetti GM, 2012, PLANTA MED, V78, P1614, DOI 10.1055/s-0032-1315377
   Peixoto L, 2013, NEUROPSYCHOPHARMACOL, V38, P62, DOI 10.1038/npp.2012.86
   Pohanka M, 2014, CURR MED CHEM, V21, P356
   Poulsen MM, 2013, ANN NY ACAD SCI, V1290, P74, DOI 10.1111/nyas.12141
   Radad K, 2011, CNS NEUROSCI THER, V17, P761, DOI 10.1111/j.1755-5949.2010.00208.x
   Raghavan A, 2012, NEURODEGENER DIS, V9, P1, DOI 10.1159/000329724
   Reitz C, 2014, BIOCHEM PHARMACOL, V88, P640, DOI 10.1016/j.bcp.2013.12.024
   Resick PA, 2012, J TRAUMA STRESS, V25, P241, DOI 10.1002/jts.21699
   Reul JMHM, 2014, FRONT PSYCHIATRY, V5, DOI [10.3389/fpsyt.2014.00005, 10.3389/fpsyt.2004.0005]
   Ringman JM, 2012, ALZHEIMERS RES THER, V4, DOI 10.1186/alzrt146
   Ritchie K, 2007, NEUROLOGY, V69, P536, DOI 10.1212/01.wnl.0000266670.35219.0c
   Rusiecki Jennifer A, 2013, Front Psychiatry, V4, P56, DOI 10.3389/fpsyt.2013.00056
   Rusiecki JA, 2012, EPIGENOMICS-UK, V4, P29, DOI [10.2217/EPI.11.116, 10.2217/epi.11.116]
   Ryan JP, 2014, J GERIATR PSYCH NEUR, V27, P47, DOI 10.1177/0891988713516543
   Samieri C, 2013, ANN INTERN MED, V159, P584, DOI 10.7326/0003-4819-159-9-201311050-00004
   Samieri C, 2013, EPIDEMIOLOGY, V24, P490, DOI 10.1097/EDE.0b013e318294a065
   Sato N, 2013, FRONT AGING NEUROSCI, V5, DOI 10.3389/fnagi.2013.00064
   Schmidt A, 2014, PSYCHOPHARMACOLOGY B
   Schmidt MV, 2013, NEUROSCIENCE, V250, P112, DOI 10.1016/j.neuroscience.2013.06.059
   Schmidt U, 2013, DIS MARKERS, V2013, P43, DOI 10.1155/2013/835876
   Schneider LS, 2014, J INTERN MED, V275, P251, DOI 10.1111/joim.12191
   Schonrock N, 2012, CELL MOL LIFE SCI, V69, P3543, DOI 10.1007/s00018-012-1125-z
   Shergis JL, 2013, PHYTOTHER RES, V27, P949, DOI 10.1002/ptr.4832
   Shukitt-Hale B, 2012, GERONTOLOGY, V58, P518, DOI 10.1159/000341101
   Sibener L, 2014, ALZHEIMERS DEMENT, V10, pS105, DOI 10.1016/j.jalz.2014.04.011
   Silva-Vargas V, 2013, CURR OPIN NEUROBIOL, V23, P935, DOI 10.1016/j.conb.2013.09.004
   Sokolov AN, 2013, NEUROSCI BIOBEHAV R, V37, P2445, DOI 10.1016/j.neubiorev.2013.06.013
   Solfrizzi V, 2011, EXPERT REV NEUROTHER, V11, P677, DOI [10.1586/ERN.11.56, 10.1586/ern.11.56]
   Sorond FA, 2013, NEUROLOGY, V81, P904, DOI 10.1212/WNL.0b013e3182a351aa
   Sperling RA, 2013, NAT REV NEUROL, V9, P54, DOI 10.1038/nrneurol.2012.241
   Srikanth V, 2011, NEUROBIOL AGING, V32, P763, DOI 10.1016/j.neurobiolaging.2009.04.016
   Stankiewicz AM, 2013, BRAIN RES BULL, V98, P76, DOI 10.1016/j.brainresbull.2013.07.003
   Stein TD, 2014, ALZHEIMERS RES THER, V6, DOI 10.1186/alzrt234
   Stilling RM, 2011, NEUROBIOL LEARN MEM, V96, P19, DOI 10.1016/j.nlm.2011.04.002
   Strong MJ, 2007, MOL CELL NEUROSCI, V35, P320, DOI 10.1016/j.mcn.2007.03.007
   Sultan FA, 2011, EPIGENOMICS-UK, V3, P157, DOI [10.2217/EPI.11.6, 10.2217/epi.11.6]
   Suphioglu C, 2010, BRIT J NUTR, V103, P344, DOI 10.1017/S0007114509991826
   Takeda S, 2011, MOL BIOSYST, V7, P1822, DOI 10.1039/c0mb00302f
   Tammen SA, 2013, MOL ASPECTS MED, V34, P753, DOI 10.1016/j.mam.2012.07.018
   Tan L, 2013, MOL NEUROBIOL, V47, P382, DOI 10.1007/s12035-012-8359-5
   Telese F, 2013, NEURON, V77, P606, DOI 10.1016/j.neuron.2013.01.034
   Thakur VS, 2012, INT J ONCOL, V41, P353, DOI 10.3892/ijo.2012.1449
   Thies W, 2013, ALZHEIMERS DEMENT, V9, P208, DOI 10.1016/j.jalz.2013.02.003
   Tiribuzi R, 2014, NEUROBIOL AGING, V35, P345, DOI 10.1016/j.neurobiolaging.2013.08.003
   Trollope AF, 2012, EXP NEUROL, V233, P3, DOI 10.1016/j.expneurol.2011.03.022
   Veerappan CS, 2013, NEUROTHERAPEUTICS, V10, P709, DOI 10.1007/s13311-013-0219-0
   Veitch DP, 2013, CURR ALZHEIMER RES, V10, P907, DOI 10.2174/15672050113109990142
   Vercambre MN, 2013, J ALZHEIMERS DIS, V35, P413, DOI 10.3233/JAD-122371
   Walker MP, 2013, AGE, V35, P519, DOI 10.1007/s11357-011-9375-5
   Wang J, 2013, AGEING RES REV, V12, P1024, DOI 10.1016/j.arr.2013.05.003
   Wang Y, 2012, PHARMACOL THERAPEUT, V136, P305, DOI 10.1016/j.pharmthera.2012.08.009
   Wierenga CE, 2014, J ALZHEIMERS DIS
   Williams RJ, 2012, FREE RADICAL BIO MED, V52, P35, DOI 10.1016/j.freeradbiomed.2011.09.010
   Wolkowitz Owen M, 2011, Dialogues Clin Neurosci, V13, P25
   Wright R, 2013, PEDIATRICS, V132, pS216, DOI 10.1542/peds.2013-1032F
   Yaffe K, 2010, ARCH GEN PSYCHIAT, V67, P608, DOI 10.1001/archgenpsychiatry.2010.61
   Yates KF, 2012, ARTERIOSCL THROM VAS, V32, P2060, DOI 10.1161/ATVBAHA.112.252759
   Yuan HD, 2012, J GINSENG RES, V36, P27, DOI 10.5142/jgr.2012.36.1.27
   Zannas AS, 2014, NEUROSCIENCE, V264, P157, DOI 10.1016/j.neuroscience.2013.12.003
   Zawia NH, 2009, FREE RADICAL BIO MED, V46, P1241, DOI 10.1016/j.freeradbiomed.2009.02.006
   Zhang Y, 2013, NEUROPSYCHOPHARMACOL, V38, P111, DOI 10.1038/npp.2012.149
NR 180
TC 19
Z9 21
U1 2
U2 39
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0193-953X
EI 1558-3147
J9 PSYCHIAT CLIN N AM
JI Psychiatr. Clin. North Amer.
PD DEC
PY 2014
VL 37
IS 4
BP 591
EP +
DI 10.1016/j.psc.2014.09.001
PG 35
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA AX0CB
UT WOS:000346620000009
PM 25455068
DA 2025-06-11
ER

PT J
AU Jurek, JM
   Xifré, B
   Rusu, EC
   Clavero-Mestres, H
   Mahmoudian, R
   Aguilar, C
   Riesco, D
   Chicote, JU
   Martinez, S
   Vives, M
   Sabench, F
   Auguet, T
AF Jurek, Joanna Michalina
   Xifre, Belen
   Rusu, Elena Cristina
   Clavero-Mestres, Helena
   Mahmoudian, Razieh
   Aguilar, Carmen
   Riesco, David
   Ugarte Chicote, Javier
   Martinez, Salome
   Vives, Marga
   Sabench, Fatima
   Auguet, Teresa
TI Differential Profiles of Gut Microbiota-Derived Metabolites of Bile
   Acids and Propionate as Potential Predictors of Depressive Disorder in
   Women with Morbid Obesity at High Risk of Metabolic
   Dysfunction-Associated Steatotic Liver Disease-A Pilot Study
SO CURRENT ISSUES IN MOLECULAR BIOLOGY
LA English
DT Article
DE depression; metabolic dysfunction-associated steatotic liver disease;
   bile acids; microbial metabolites; obesity
ID MASLD
AB Metabolic dysfunction-associated steatotic liver disease (MASLD) is a liver condition linked to cardiometabolic diseases and mental health issues, with studies highlighting disruptions in gut microbiota activity, including bile acid (BA) metabolism. Therefore, the main aim of this exploratory analysis was to assess microbiota-derived metabolites, specifically BAs and short-chain fatty acids (SCFAs), as potential biomarkers of depressive disorder (DD) in women with morbid obesity at MASLD risk. In this pilot study, 33 females with morbid obesity who were scheduled for bariatric surgery were evaluated. Medical and clinical data were collected, and microbial metabolites from pre-surgery blood samples were analyzed. Patients were stratified according to the presence of DD. Analysis with Spearman's rank test was used to assess correlations and logistic regression models were built to evaluate biomarkers as predictors of DD risk using both receiver operating characteristic (ROC) and precision-recall curves. In this cohort, 30.3% of females were reported to have DD, in addition to significantly elevated levels of certain BAs and SCFAs, including glycodeoxycholic acid (GDCA) and propionate, which were also correlated with some metabolic biomarkers. However, there were no differences in the incidence of MASLD or metabolic syndrome between patients with DD or without. In conclusion, microbiota-derived metabolites such as GDCA and propionate may influence DD risk in females with morbid obesity; however, their potential use as predictive biomarkers should be further investigated to confirm their role in psycho-metabolic conditions.
C1 [Jurek, Joanna Michalina; Rusu, Elena Cristina; Clavero-Mestres, Helena; Mahmoudian, Razieh; Aguilar, Carmen; Riesco, David; Ugarte Chicote, Javier; Martinez, Salome; Sabench, Fatima; Auguet, Teresa] Univ Rovira & Virgili URV, Inst Invest Sanitaria Pere Virgili IISPV, Dept Med & Cirurg, Grp Recerca GEMMAIR AGAUR Med Aplicada URV, Mallafre Guasch 4, Tarragona 43007, Spain.
   [Xifre, Belen] Hosp Vendrell, Serv Med Interna, Ctra Barcelona S-N, Tarragona 43700, Spain.
   [Riesco, David; Auguet, Teresa] Hosp Univ Tarragona Joan XXIII, Serv Med Interna, Mallafre Guasch, Mallafre Guasch 4, Tarragona 43007, Spain.
   [Ugarte Chicote, Javier; Martinez, Salome] Hosp Univ Tarragona Joan XXIII, Serv Anat Patol, Mallafre Guasch 4, Tarragona 43007, Spain.
   [Vives, Marga; Sabench, Fatima] Univ Rovira & Virgili URV, Inst Invest Sanitaria Pere Virgili IISPV, Hosp St Joan Reus, Dept Med & Cirurgia,Serv Cirurgia, Avinguda Doctor Josep Laporte 2, Reus 43204, Spain.
C3 Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV); Universitat Rovira i Virgili; Hospital Universitari De
   Tarragona Joan XXIII; Universitat Rovira i Virgili; Hospital
   Universitari De Tarragona Joan XXIII; Universitat Rovira i Virgili;
   Institut d'Investigacio Sanitaria Pere Virgili (IISPV)
RP Auguet, T (corresponding author), Univ Rovira & Virgili URV, Inst Invest Sanitaria Pere Virgili IISPV, Dept Med & Cirurg, Grp Recerca GEMMAIR AGAUR Med Aplicada URV, Mallafre Guasch 4, Tarragona 43007, Spain.; Auguet, T (corresponding author), Hosp Univ Tarragona Joan XXIII, Serv Med Interna, Mallafre Guasch, Mallafre Guasch 4, Tarragona 43007, Spain.
EM joanna.michalina.jurek@gmail.com; elena.cristina.rusu@gmail.com;
   helena.clavero@urv.cat; tauguet.hj23.ics@gencat.cat
RI Auguet, Teresa/AAC-5838-2020; Sabench, Fatima/HSG-1966-2023
FU Agencia de Gestio d'Ajuts Universitaris de Recerca (AGAUR) [SGR 00030];
   URV [2021-10-837-AUGUET, 2023POST-INV-10, E-43-20232-0070021]
FX This research received external funding from Agencia de Gestio d'Ajuts
   Universitaris de Recerca (AGAUR 2021 SGR 00030 to Teresa Auguet) via
   Investigador actiu Program from the URV (2021-10-837-AUGUET to Teresa
   Auguet), via Programa INVESTIGO-URV-Codigo: 2023POST-INV-10 by Next
   Generation EU, and via Programa INVESTIGO-IISPV-Codigo:
   E-43-20232-0070021 by Next Generation EU.
CR Åström H, 2024, LIVER INT, V44, P2551, DOI 10.1111/liv.16019
   Auguet T, 2022, PROCESSES, V10, DOI 10.3390/pr10010143
   Auguet T, 2014, INT J MOL SCI, V15, P22173, DOI 10.3390/ijms151222173
   Bonilla-Jaime H, 2022, CURR NEUROPHARMACOL, V20, P384, DOI 10.2174/1570159X19666210609161447
   Brunt EM, 1999, AM J GASTROENTEROL, V94, P2467, DOI 10.1111/j.1572-0241.1999.01377.x
   Cai HW, 2023, J AFFECT DISORDERS, V334, P332, DOI 10.1016/j.jad.2023.04.093
   Chan WK, 2023, J OBES METAB SYNDR, V32, P197, DOI 10.7570/jomes23052
   Chen SM, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1268865
   Custodio RJP, 2023, CELLS-BASEL, V12, DOI 10.3390/cells12182331
   de Groot Mary, 2023, Am J Med Open, V9, P100039, DOI 10.1016/j.ajmo.2023.100039
   Di Ciaula A, 2017, ANN HEPATOL, V16, pS4, DOI 10.5604/01.3001.0010.5493
   Drevets WC, 2022, NAT REV DRUG DISCOV, V21, P224, DOI 10.1038/s41573-021-00368-1
   Faraj SS, 2023, ANN MED SURG, V85, P2291, DOI 10.1097/MS9.0000000000000679
   Ferrell JM, 2019, DIABETES METAB J, V43, P257
   Ha SK, 2025, GUT, V74, P141, DOI 10.1136/gutjnl-2024-332398
   Hashimoto K, 2022, PSYCHIAT CLIN NEUROS, V76, P281, DOI 10.1111/pcn.13370
   Hassamal S, 2023, FRONT PSYCHIATRY, V14, DOI 10.3389/fpsyt.2023.1130989
   Iwaki M, 2023, HEPATOL COMMUN, V7, DOI 10.1097/HC9.0000000000000285
   Kany S, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20236008
   Kessing LV, 2020, DIABETES CARE, V43, P3050, DOI 10.2337/dc20-1561
   Kimura I, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00085
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Lai JM, 2023, BIOMOLECULES, V13, DOI 10.3390/biom13091356
   Li HX, 2023, BMC PSYCHIATRY, V23, DOI 10.1186/s12888-023-04684-1
   Li Tiangang, 2024, eGastroenterology, V2, DOI 10.1136/egastro-2024-100074
   Li Y, 2023, CELL DEATH DIS, V14, DOI 10.1038/s41419-023-06111-5
   Liang JX, 2023, J HEPATOL, V79, DOI 10.1016/j.jhep.2023.04.025
   Liu C, 2021, ADV SCI, V8, DOI 10.1002/advs.202004433
   Liu JJ, 2023, NPJ BIOFILMS MICROBI, V9, DOI 10.1038/s41522-023-00399-z
   Liu LX, 2023, EBIOMEDICINE, V90, DOI 10.1016/j.ebiom.2023.104527
   Liu XF, 2023, FRONT IMMUNOL, V14, DOI 10.3389/fimmu.2023.1186892
   Luo M, 2023, WORLD J GASTROENTERO, V29, P144, DOI 10.3748/wjg.v29.i1.144
   MahmoudianDehkordi S, 2022, FRONT NEUROSCI-SWITZ, V16, DOI 10.3389/fnins.2022.937906
   Markowitz SM, 2011, PSYCHOSOMATICS, V52, P1, DOI 10.1016/j.psym.2010.11.007
   Ntona S, 2023, NEUROCHEM INT, V163, DOI 10.1016/j.neuint.2023.105484
   Ortiz-López N, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.954869
   Park S, 2024, BIOMEDICINES, V12, DOI 10.3390/biomedicines12040873
   Pedregosa F, 2011, J MACH LEARN RES, V12, P2825
   Popov J, 2024, NUTRIENTS, V16, DOI 10.3390/nu16111668
   Rasouli N, 2008, J CLIN ENDOCR METAB, V93, pS64, DOI 10.1210/jc.2008-1613
   Silva YP, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00025
   Skonieczna-Zydecka K, 2018, NUTRIENTS, V10, DOI 10.3390/nu10121939
   Sternby H, 2021, BIOMOLECULES, V11, DOI 10.3390/biom11040591
   Sun N, 2022, PSYCHIAT CLIN NEUROS, V76, P321, DOI 10.1111/pcn.13368
   Szczesniak O, 2016, NUTR NEUROSCI, V19, P279, DOI 10.1179/1476830515Y.0000000007
   Targher G, 2024, GUT, V73, P691, DOI 10.1136/gutjnl-2023-330595
   Tomkin GH, 2016, J TRANSL INTERN MED, V4, P73, DOI 10.1515/jtim-2016-0018
   Tung TH, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10071594
   Velazquez-Villegas LA, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-017-02068-0
   Wang HX, 2021, NUTR NEUROSCI, V24, P885, DOI 10.1080/1028415X.2019.1691856
   Wang Yanyan, 2024, Med Rev (2021), V4, P262, DOI 10.1515/mr-2024-0020
   Wu LR, 2022, PROTEOMICS, V22, DOI 10.1002/pmic.202100324
   Xiao JL, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.691696
   Yan MY, 2023, SIGNAL TRANSDUCT TAR, V8, DOI 10.1038/s41392-023-01673-4
   Youssef NA, 2013, LIVER INT, V33, P1062, DOI 10.1111/liv.12165
   Zhou J, 2021, HEPATOMA RES, V7, DOI 10.20517/2394-5079.2020.134
NR 56
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1467-3037
EI 1467-3045
J9 CURR ISSUES MOL BIOL
JI Curr. Issues Mol. Biol.
PD MAY 12
PY 2025
VL 47
IS 5
AR 353
DI 10.3390/cimb47050353
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 3AH7K
UT WOS:001495575200001
DA 2025-06-11
ER

PT J
AU Wang, Q
   Zhu, XC
   Liu, H
   Ran, MS
   Fang, DZ
AF Wang, Qian
   Zhu, Xing Chun
   Liu, Hui
   Ran, Mao Sheng
   Fang, Ding Zhi
TI A longitudinal study of the association of adiponectin gene rs1501299
   with depression in Chinese Han adolescents after Wenchuan earthquake
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Adiponectin; Genetic variation; Depression; Adolescent; Earthquake
ID CORONARY-ARTERY-DISEASE; MAJOR DEPRESSION; METABOLIC SYNDROME; SERUM
   ADIPONECTIN; PLASMA; RISK; SYMPTOMS; RESISTIN; ATHEROSCLEROSIS;
   POLYMORPHISMS
AB Background: Previous studies showed inconsistent results of the association between plasma adiponectin and depression. The aim of this study is to longitudinally investigate the association of adiponectin is 1501299 with depression in Chinese Han adolescents who experienced the 2008 Wenchuan earthquake.
   Method: Variants of adiponectin rs1501299 were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Depressive symptoms were assessed by Beck Depression Inventory (BDI) among 746 high school students at 6, 12 and 18 months after the earthquake.
   Results: The female T allele carriers of adiponectin rs1501299 had lower prevalence of depression (p=0.008) and BDI scores (p=0.024) than the female GG homozygotes at 18 months, but not at 6 or 12 months after the earthquake, which were significantly reduced (p=0.022 for the prevalence and p < 0.001 for the scores) in the female T allele carriers at 18 months after the earthquake when compared with those at 12 months. In addition, the major predictors of depression for the GG homozygotes were gender and age at 6, 12 and 18 months after earthquake. On the other hand, the major predictor for the T allele carriers was gender at 6, 12 and 18 months after earthquake.
   Limitations: There were some limitations in the present study. First, adiponectin expressions including serum adiponectin and mRNA in adipose tissues were not measured. Second, the effect of body mass index was not evaluated.
   Conclusions: The adiponectin T allele is associated with reduced prevalence of depression and lower BDI scores of female adolescents in the later stage of rehabilitation of depression. (C) 2015 Elsevier By. All rights reserved.
C1 [Wang, Qian; Zhu, Xing Chun; Liu, Hui; Fang, Ding Zhi] Sichuan Univ, West China Sch Preclin & Forens Med, Dept Biochem & Mol Biol, Chengdu 610064, Peoples R China.
   [Ran, Mao Sheng] Univ Hong Kong, Dept Social Work & Social Adm, Hong Kong, Hong Kong, Peoples R China.
C3 Sichuan University; University of Hong Kong
RP Ran, MS (corresponding author), Univ Hong Kong, Dept Social Work & Social Adm, Hong Kong, Hong Kong, Peoples R China.
EM ranmaosh@yahoo.com; dzfang@scu.edu.cn
RI Ran, Mao-Sheng/I-7957-2013
OI Ran, Mao-Sheng/0000-0001-7343-3729
FU National Natural Science Foundation of China [81370375]
FX The study was supported by the National Natural Science Foundation of
   China (Grant no. 81370375). Dr. Ding Zhi Fang is the recipient of the
   grant.
CR AlSaleh A, 2011, AM J CLIN NUTR, V94, P262, DOI 10.3945/ajcn.111.014209
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   Brislin R.W., 1976, Translation: Applications and Research, P1
   Delaigle AM, 2004, ENDOCRINOLOGY, V145, P5589, DOI 10.1210/en.2004-0503
   Diniz BS, 2012, J PSYCHIATR RES, V46, P1081, DOI 10.1016/j.jpsychires.2012.04.028
   Filippi E, 2005, J MOL MED, V83, P711, DOI 10.1007/s00109-005-0667-z
   Fredriksson J, 2006, INT J OBESITY, V30, P226, DOI 10.1038/sj.ijo.0803138
   Hara K, 2002, DIABETES, V51, P536, DOI 10.2337/diabetes.51.2.536
   Hotta K, 2000, ARTERIOSCL THROM VAS, V20, P1595, DOI 10.1161/01.ATV.20.6.1595
   Hryhorczuk C, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00177
   Krízová J, 2008, PHYSIOL RES, V57, P539, DOI 10.33549/physiolres.931195
   Lehto SM, 2010, ACTA PSYCHIAT SCAND, V121, P209, DOI 10.1111/j.1600-0447.2009.01463.x
   Leo R, 2006, NEUROSCI LETT, V407, P211, DOI 10.1016/j.neulet.2006.08.043
   Liu J, 2012, P NATL ACAD SCI USA, V109, P12248, DOI 10.1073/pnas.1202835109
   Marijnissen RM, 2013, J AFFECT DISORDERS, V151, P1138, DOI 10.1016/j.jad.2013.07.029
   Mclntyre R. S., 2006, CAN J PSYCHIAT, V51, P274
   Narita K, 2008, PROG NEURO-PSYCHOPH, V32, P124, DOI 10.1016/j.pnpbp.2007.07.022
   Okamoto Y, 2002, CIRCULATION, V106, P2767, DOI 10.1161/01.CIR.0000042707.50032.19
   Pan A, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001392
   Pariante CM, 2008, TRENDS NEUROSCI, V31, P464, DOI 10.1016/j.tins.2008.06.006
   Piñeiro R, 2005, FEBS LETT, V579, P5163, DOI 10.1016/j.febslet.2005.07.098
   Pischon T, 2004, JAMA-J AM MED ASSOC, V291, P1730, DOI 10.1001/jama.291.14.1730
   Pyrzak B, 2013, ADV EXP MED BIOL, V756, P247, DOI 10.1007/978-94-007-4549-0_31
   Ruggiero KJ, 2012, DISASTER MED PUBLIC, V6, P26, DOI 10.1001/dmp.2012.7
   Rumsfeld JS, 2005, CIRCULATION, V111, P250, DOI 10.1161/01.CIR.0000154573.62822.89
   SHEK DTL, 1991, J CLIN PSYCHOL, V47, P381, DOI 10.1002/1097-4679(199105)47:3<381::AID-JCLP2270470309>3.0.CO;2-D
   Tang BH, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-623
   Tong GX, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-67
   Wang Y, 2006, ARCH CLIN NEUROPSYCH, V21, P339, DOI 10.1016/j.acn.2006.03.006
   Weber-Hamann B, 2007, J PSYCHIATR RES, V41, P344, DOI 10.1016/j.jpsychires.2006.01.002
   Wilhelm CJ, 2013, PHARMACOL BIOCHEM BE, V103, P643, DOI 10.1016/j.pbb.2012.11.001
   Xu AM, 2005, J BIOL CHEM, V280, P18073, DOI 10.1074/jbc.M414231200
   Yang WS, 2001, J CLIN ENDOCR METAB, V86, P3815, DOI 10.1210/jc.86.8.3815
   Zhang Z, 2012, PSYCHOL MED, V42, P1687, DOI 10.1017/S0033291711002844
NR 34
TC 8
Z9 8
U1 0
U2 23
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD APR 1
PY 2015
VL 175
BP 86
EP 91
DI 10.1016/j.jad.2014.12.056
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA CD3JL
UT WOS:000350974300009
PM 25597795
DA 2025-06-11
ER

PT J
AU Jaarsma, C
   Vink, H
   van Haare, J
   Bekkers, SCAM
   van Rooijen, BD
   Backes, WH
   Wildberger, JE
   Crijns, HJ
   van Teeffelen, J
   Schalla, S
AF Jaarsma, Caroline
   Vink, Hans
   van Haare, Judith
   Bekkers, Sebastiaan C. A. M.
   van Rooijen, Bart D.
   Backes, Walter H.
   Wildberger, Joachim E.
   Crijns, Harry J.
   van Teeffelen, Jurgen
   Schalla, Simon
TI Non-invasive assessment of microvascular dysfunction in patients with
   microvascular angina
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Endothelium; Imaging; Magnetic resonance imaging; Microcirculation;
   Syndrome X
ID CARDIAC SYNDROME-X; CARDIOVASCULAR MAGNETIC-RESONANCE;
   CORONARY-ARTERY-DISEASE; TRANSMURAL MYOCARDIAL-PERFUSION; GLYCOCALYX
   BARRIER PROPERTIES; ENDOTHELIAL GLYCOCALYX; CHEST-PAIN; ISCHEMIA;
   RESERVE; FLOW
AB Background: We aimed to evaluate the microvascular function in patients with microvascular angina (MVA) by assessing 1) the endothelial glycocalyx barrier properties using sublingual microscopy, and 2) the myocardial perfusion reserve using cardiovascular magnetic resonance (CMR) imaging.
   Methods: Sublingual microscopy was performed in 13MVA patients (angina pectoris, ST-depression on treadmill testing, normal coronary angiogram) and comparedwith 2 control groups of 13 volunteers and 14 patients with known obstructive coronary artery disease (CAD). To test the glycocalyx-mediated microvascular responsiveness, the erythrocyte perfused boundary region (PBR) was assessed at baseline and after nitroglycerin challenge.
   Results: The baseline PBR of MVA patients was similar to controls with CAD (p = 0.72), and larger than in volunteers (p = 0.02). Only the volunteers demonstrated a significant increase in PBR after nitroglycerin (p = 0.03). In the 13MVA patients, adenosine stress CMR perfusion imaging was performed. Although a significant increase in myocardial perfusion was observed in both the subendocardiumand subepicardium during stress, the subendocardial perfusion reserve was significantly lower (p = 0.02). The PBR responsiveness of the sublingual microvasculature showed a strong correlation with the transmural myocardial perfusion reserve (r = 0.86, p < 0.001).
   Conclusions: Patients with MVA can be characterized by microvascular glycocalyx dysfunction using sublingual microscopy. The strong correlation between sublingual PBR responsiveness and myocardial perfusion reserve suggests that the glycocalyx may play an important role in the regulation of microvascular volume for myocardial perfusion and supports the concept of impaired glycocalyx barrier properties in MVA. (C) 2017 Elsevier B.V. All rights reserved.
C1 [Jaarsma, Caroline; Bekkers, Sebastiaan C. A. M.; Crijns, Harry J.; Schalla, Simon] Maastricht Univ, Med Ctr, Dept Cardiol, P Debyelaan 25,POB 5800, NL-6202 AZ Maastricht, Netherlands.
   [Bekkers, Sebastiaan C. A. M.; van Rooijen, Bart D.; Backes, Walter H.; Wildberger, Joachim E.; Schalla, Simon] Maastricht Univ, Med Ctr, Dept Radiol & Nucl Med, Maastricht, Netherlands.
   [Vink, Hans; van Haare, Judith; van Teeffelen, Jurgen] Maastricht Univ, Dept Physiol, Maastricht, Netherlands.
   [Vink, Hans; van Haare, Judith; Bekkers, Sebastiaan C. A. M.; Wildberger, Joachim E.; Crijns, Harry J.; van Teeffelen, Jurgen; Schalla, Simon] Maastricht Univ, Cardiovasc Res Inst Maastricht CARIM, Maastricht, Netherlands.
C3 Maastricht University; Maastricht University Medical Centre (MUMC);
   Maastricht University; Maastricht University; Maastricht University
RP Schalla, S (corresponding author), Maastricht Univ, Med Ctr, Dept Cardiol, P Debyelaan 25,POB 5800, NL-6202 AZ Maastricht, Netherlands.
EM s.schalla@mumc.nl
RI Bekkers, Sebastiaan/Y-1484-2019; Crijns, Harry/ACF-4932-2022
OI Wildberger, Joachim/0000-0002-4810-6854
FU Netherlands Heart Foundation [2009B056]
FX This study was supported by the Netherlands Heart Foundation (grant
   #2009B056).
CR Algranati D, 2011, AM J PHYSIOL-HEART C, V300, pH1090, DOI 10.1152/ajpheart.00473.2010
   Becker BF, 2010, CARDIOVASC RES, V87, P300, DOI 10.1093/cvr/cvq137
   Brands J, 2010, AM J PHYSIOL-HEART C, V298, pH515, DOI 10.1152/ajpheart.01306.2008
   Broekhuizen LN, 2010, DIABETOLOGIA, V53, P2646, DOI 10.1007/s00125-010-1910-x
   CANNON RO, 1988, AM J CARDIOL, V61, P1338, DOI 10.1016/0002-9149(88)91180-0
   Cerqueira MD, 2002, CIRCULATION, V105, P539, DOI 10.1161/hc0402.102975
   Crea F, 2004, HEART, V90, P457, DOI 10.1136/hrt.2003.020594
   Goedhart PT, 2007, OPT EXPRESS, V15, P15101, DOI 10.1364/OE.15.015101
   HOFFMAN JIE, 1985, J BIOMECH ENG-T ASME, V107, P2, DOI 10.1115/1.3138516
   HOFFMAN JIE, 1987, PROG CARDIOVASC DIS, V29, P429, DOI 10.1016/0033-0620(87)90016-8
   Ichihara T, 2009, MAGN RESON MED, V62, P373, DOI 10.1002/mrm.22018
   Ishimori ML, 2011, JACC-CARDIOVASC IMAG, V4, P27, DOI 10.1016/j.jcmg.2010.09.019
   Karamitsos TD, 2012, CIRC-CARDIOVASC IMAG, V5, P194, DOI 10.1161/CIRCIMAGING.111.969667
   Kobayashi Y, 2010, ARTHRITIS RES THER, V12, DOI 10.1186/ar3131
   Kurita T, 2009, EUR HEART J, V30, P444, DOI 10.1093/eurheartj/ehn521
   Lanza GA, 2007, HEART, V93, P159, DOI 10.1136/hrt.2005.067330
   Lanza GA, 2008, J AM COLL CARDIOL, V51, P466, DOI 10.1016/j.jacc.2007.08.060
   Larghat A, 2012, INT J CARDIOVAS IMAG, V28, P1499, DOI 10.1007/s10554-011-9982-3
   Lee DH, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0096477
   Lockie T, 2011, J AM COLL CARDIOL, V57, P70, DOI 10.1016/j.jacc.2010.09.019
   Martens RJH, 2013, CEREBROVASC DIS, V35, P451, DOI 10.1159/000348854
   Mehta PK, 2011, JACC-CARDIOVASC IMAG, V4, P514, DOI 10.1016/j.jcmg.2011.03.007
   Montalescot G, 2013, EUR HEART J, V34, P2949, DOI 10.1093/eurheartj/eht296
   Muehling OM, 2003, J AM COLL CARDIOL, V42, P1054, DOI 10.1016/S0735-1097(03)00924-0
   Mulders TA, 2013, INT J CARDIOL, V168, P5026, DOI 10.1016/j.ijcard.2013.07.166
   Nieuwdorp M, 2006, DIABETES, V55, P1127, DOI 10.2337/diabetes.55.04.06.db05-1619
   Nieuwdorp M, 2006, DIABETES, V55, P480, DOI 10.2337/diabetes.55.02.06.db05-1103
   Nieuwdorp M, 2005, CURR OPIN LIPIDOL, V16, P507, DOI 10.1097/01.mol.0000181325.08926.9c
   Panting JR, 2002, NEW ENGL J MED, V346, P1948, DOI 10.1056/NEJMoa012369
   PATLAK CS, 1983, J CEREBR BLOOD F MET, V3, P1, DOI 10.1038/jcbfm.1983.1
   Plein S, 2007, MAGN RESON MED, V58, P777, DOI 10.1002/mrm.21381
   Pries AR, 2017, EUR HEART J, V38, P478, DOI 10.1093/eurheartj/ehv760
   Thomson LEJ, 2015, CIRC-CARDIOVASC IMAG, V8, DOI 10.1161/CIRCIMAGING.114.002481
   Van Teeffelen JWGE, 2008, J PHYSIOL-LONDON, V586, P3207, DOI 10.1113/jphysiol.2008.152975
   VanTeeffelen JW, 2007, TRENDS CARDIOVAS MED, V17, P101, DOI 10.1016/j.tcm.2007.02.002
   VanTeeffelen JWGE, 2010, CARDIOVASC RES, V87, P311, DOI 10.1093/cvr/cvq114
   Vermeltfoort IAC, 2007, EUR HEART J, V28, P1554, DOI 10.1093/eurheartj/ehm088
   Vlahu CA, 2012, J AM SOC NEPHROL, V23, P1900, DOI 10.1681/ASN.2011121181
NR 38
TC 18
Z9 19
U1 0
U2 18
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD DEC 1
PY 2017
VL 248
BP 433
EP 439
DI 10.1016/j.ijcard.2017.05.010
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FH8JG
UT WOS:000411439900080
PM 28733074
OA hybrid
DA 2025-06-11
ER

PT J
AU Berenbaum, F
AF Berenbaum, Francis
TI Republished viewpoint: Diabetes-induced osteoarthritis: from a new
   paradigm to a new phenotype
SO POSTGRADUATE MEDICAL JOURNAL
LA English
DT Article
ID GLYCATION END-PRODUCTS; METABOLIC SYNDROME; OXIDATIVE STRESS; ARTICULAR
   CHONDROCYTES; GLUCOSE-TRANSPORT; KNEE; CARTILAGE; HYPERGLYCEMIA;
   INFLAMMATION; ACTIVATION
AB Several epidemiological and experimental data support the hypothesis that diabetes could be an independent risk factor for osteoarthritis (OA), at least in some patients, leading to the concept of a diabetes-induced OA phenotype. If confirmed, this new paradigm will have a dramatic impact on prevention of QA intiation and progression.
C1 Univ Paris 06, Hop St Antoine, APHP, Dept Rheumatol, Paris, France.
C3 Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital
   Universitaire Saint-Antoine - APHP; Universite Paris Cite; Hopital
   Universitaire Hotel-Dieu - APHP; Hopital Universitaire Ambroise-Pare -
   APHP
RP Berenbaum, F (corresponding author), Univ Paris 06, Hop St Antoine, APHP, Dept Rheumatol, Paris, France.
EM francis.berenbaum@sat.aphp.fr
RI Berenbaum, Francis/AAO-5690-2020
OI berenbaum, francis/0000-0001-8252-7815
CR A Mobasheii, 2008, ADV ANAT EMBRYOL CEL, P200
   ANDERSON JJ, 1988, AM J EPIDEMIOL, V128, P179, DOI 10.1093/oxfordjournals.aje.a114939
   Atayde SA, 2010, ARTHRITIS RHEUM S10, V62, pS368
   BROWNLEE M, 1988, NEW ENGL J MED, V318, P1315
   Cadwell BL., 2010, J Data Sci, V8, P173
   Cecil DL, 2005, J IMMUNOL, V175, P8296, DOI 10.4049/jimmunol.175.12.8296
   CIMMINO MA, 1990, CLIN EXP RHEUMATOL, V8, P251
   Engström G, 2009, OSTEOARTHR CARTILAGE, V17, P168, DOI 10.1016/j.joca.2008.07.003
   Esposito K, 2002, CIRCULATION, V106, P2067, DOI 10.1161/01.CIR.0000034509.14906.AE
   Frey MI, 1996, J RHEUMATOL, V23, P716
   HART DJ, 1995, J RHEUMATOL, V22, P1118
   Henrotin YE, 2003, OSTEOARTHR CARTILAGE, V11, P747, DOI 10.1016/S1063-4584(03)00150-X
   Herrero-Beaumont G, 2009, SEMIN ARTHRITIS RHEU, V39, P71, DOI 10.1016/j.semarthrit.2009.03.006
   Hurley MV, 1999, RHEUM DIS CLIN N AM, V25, P283, DOI 10.1016/S0889-857X(05)70068-5
   Igarashi M, 1999, J CLIN INVEST, V103, P185, DOI 10.1172/JCI3326
   KELLEY KM, 1993, DIABETES, V42, P463, DOI 10.2337/diabetes.42.3.463
   Ling PR, 2003, METABOLISM, V52, P868, DOI 10.1016/S0026-0495(03)00057-X
   Loeser RF, 2005, ARTHRITIS RHEUM, V52, P2376, DOI 10.1002/art.21199
   MAROUDAS A, 1968, Journal of Bone and Joint Surgery British Volume, V50B, P166
   McNulty AL, 2005, ARTHRITIS RHEUM-US, V52, P2676, DOI 10.1002/art.21254
   Pottie P, 2006, ANN RHEUM DIS, V65, P1403, DOI 10.1136/ard.2006.061994
   Puenpatom RA, 2009, POSTGRAD MED, V121, P9, DOI 10.3810/pgm.2009.11.2073
   Ramasamy R, 2005, GLYCOBIOLOGY, V15, p16R, DOI 10.1093/glycob/cwi053
   Rosa SC, 2009, ARTHRITIS RES THER, V11, DOI 10.1186/ar2713
   Schett G, 2009, ARTHRITIS RHEUM-US, V60, P2381, DOI 10.1002/art.24757
   Shakoor N, 2008, ARTHRIT RHEUM-ARTHR, V59, P1237, DOI 10.1002/art.24004
   Shikhman AR, 2001, J IMMUNOL, V167, P7001, DOI 10.4049/jimmunol.167.12.7001
   Slemenda C, 1997, ANN INTERN MED, V127, P97, DOI 10.7326/0003-4819-127-2-199707150-00001
   Stannus O, 2010, OSTEOARTHR CARTILAGE, V18, P1441, DOI 10.1016/j.joca.2010.08.016
   Steenvoorden MMC, 2006, ARTHRITIS RHEUM-US, V54, P253, DOI 10.1002/art.21523
   Stürmer T, 2001, SCAND J RHEUMATOL, V30, P169
   van Sloten TT, 2011, DIABETES RES CLIN PR, V91, P32, DOI 10.1016/j.diabres.2010.09.030
   Velasquez MT, 2010, METAB SYNDR RELAT D, V8, P295, DOI 10.1089/met.2009.0110
   Verzijl N, 2002, ARTHRITIS RHEUM, V46, P114, DOI 10.1002/1529-0131(200201)46:1<114::AID-ART10025>3.0.CO;2-P
   WAINE H, 1961, Tufts Folia Med, V7, P13
   Yan SF, 2010, CIRC RES, V106, P842, DOI 10.1161/CIRCRESAHA.109.212217
   Yerneni KKV, 1999, DIABETES, V48, P855, DOI 10.2337/diabetes.48.4.855
NR 37
TC 45
Z9 53
U1 0
U2 6
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0032-5473
EI 1469-0756
J9 POSTGRAD MED J
JI Postgrad. Med. J.
PD APR
PY 2012
VL 88
IS 1038
BP 240
EP 242
DI 10.1136/pgmj.2010.146399rep
PG 3
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 916QS
UT WOS:000302118900010
PM 22441236
DA 2025-06-11
ER

PT J
AU Thalitaya, MD
   Udu, V
   Nicholls, M
   Clark, T
   Prasher, VP
AF Thalitaya, Madhusudan Deepak
   Udu, Victor
   Nicholls, Maggie
   Clark, Terry
   Prasher, Verinder P.
TI POMHS 9B-ANTIPSYCHOTIC PRESCRIBING IN PEOPLE WITH A LEARNING DISABILITY
SO PSYCHIATRIA DANUBINA
LA English
DT Article
DE antipsyschotic prescribing; learning diisabilty
AB Introduction: Prescribing Observatory for Mental Health (POMH-UK) runs national audit-based quality improvement programmes open to all specialist mental health services in the UK to help improve prescribing practice in discrete areas.
   Aims: The baseline sample and this re-audit represent the largest audits of antipsychotic prescribing in PWLD that have been conducted to date; and thus provide the most generalisable picture of such prescribing nationally.
   Methodology: A case note audit of use of antipsychotic medication in PWLD was conducted using standard data collection tool provided by POMH-UK. Trust wide, 7 clinical teams in Essex and Bedfordshire & Luton, participated in the re-audit. Analysis and benchmarking was conducted centrally by POMH-UK and an individualised Trust report was compiled by POMH-UK for local review and consideration.
   Standards: The indication for treatment with antipsychotic medication should be documented in the clinical records (Deb 2006). The continuing need for antipsychotic medication should be reviewed at least once a year (Deb 2006). Side effects of antipsychotic medication should be reviewed at least once a year. This review should include assessment for the presence of extrapyramidal side effects (EPS), and screening for the 4 aspects of the metabolic syndrome: obesity, hypertension, impaired glucose tolerance and dyslipidaemia (NICE schizophrenia guideline update CG82, 2009).
   Findings: Out of three standards measured, Standard One maintained 100% throughout the baseline and re-audit and Standard Two achieved over 90% throughout baseline and re-audit. Standard 3 has improved from baseline to re-audit. Overall, there has been clear improvement in all 3 standards from baseline audit.
C1 [Thalitaya, Madhusudan Deepak; Udu, Victor; Nicholls, Maggie; Clark, Terry; Prasher, Verinder P.] S Essex Partnership Univ NHS Fdn Trust, Twinwoods Med Ctr, Clapham MK41 6AT, Beds, England.
RP Thalitaya, MD (corresponding author), S Essex Partnership Univ NHS Fdn Trust, Twinwoods Med Ctr, Milton Rd, Clapham MK41 6AT, Beds, England.
EM Deepak.thalitaya@sept.nhs.uk
CR Deb S., 2006, Using medication to manage behaviour problems among adults with a learning disability: quick reference guide
   *NICE, 2009, NICE CLIN GUID MAN S
NR 2
TC 2
Z9 2
U1 0
U2 3
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PD SEP
PY 2011
VL 23
SU 1
BP S50
EP S56
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 822DG
UT WOS:000295023500013
PM 21894103
DA 2025-06-11
ER

PT J
AU Bahijri, S
   Borai, A
   Ajabnoor, G
   Khaliq, AA
   AlQassas, I
   Al-Shehri, D
   Chrousos, G
AF Bahijri, Suhad
   Borai, Anwar
   Ajabnoor, Ghada
   Khaliq, Altaf Abdul
   AlQassas, Ibrahim
   Al-Shehri, Dhafer
   Chrousos, George
TI Relative Metabolic Stability, but Disrupted Circadian Cortisol Secretion
   during the Fasting Month of Ramadan
SO PLOS ONE
LA English
DT Article
ID SLEEP-DEPRIVATION; GENE-EXPRESSION; CONSEQUENCES; STRESS; PLASMA;
   DEPRESSION; RHYTHM; MODEL; ACTH
AB Background: Chronic feeding and sleep schedule disturbances are stressors that exert damaging effects on the organism. Practicing Muslims in Saudi Arabia go through strict Ramadan fasting from dawn till sunset for one month yearly. Modern era Ramadan practices in Saudi Arabia are associated with disturbed feeding and sleep patterns, namely abstaining from food and water and increasing daytime sleep, and staying awake and receiving food and water till dawn.
   Hypothesis: Strict Ramadan practices in Saudi Arabia may influence metabolism, sleep and circadian cortisol secretion.
   Protocol: Young, male Ramadan practitioners were evaluated before and two weeks into the Ramadan. Blood samples were collected at 9.00 am and 9.00 pm for measurements of metabolic parameters and cortisol. Saliva was collected serially during the day for cortisol determinations.
   Results: Ramadan practitioners had relative metabolic stability or changes expected by the pattern of feeding. However, the cortisol circadian rhythm was abolished and circulating insulin levels and HOMA index were increased during this period.
   Discussion: The flattening of the cortisol rhythm is typical of conditions associated with chronic stress or endogenous hypercortisolism and associated with insulin resistance.
   Conclusions: Modern Ramadan practices in Saudi Arabia are associated with evening hypercortisolism and increased insulin resistance. These changes might contribute to the high prevalence of chronic stress-related conditions, such as central obesity, hypertension, metabolic syndrome and diabetes mellitus type 2, and their cardiovascular sequelae observed in the Kingdom.
C1 [Bahijri, Suhad; Ajabnoor, Ghada] King Abdulaziz Univ, Fac Med, Dept Clin Biochem, Jeddah 21413, Saudi Arabia.
   [Bahijri, Suhad; Borai, Anwar; Ajabnoor, Ghada; Khaliq, Altaf Abdul; AlQassas, Ibrahim; Al-Shehri, Dhafer; Chrousos, George] King Abdulaziz Univ, King Fahd Med Res Ctr, Saudi Diabet Study Res Grp, Jeddah 21413, Saudi Arabia.
   [Borai, Anwar] King Abdul Aziz Med City, King Abdullah Int Med Res Ctr, Jeddah, Saudi Arabia.
   [Khaliq, Altaf Abdul] Um Alqura Univ, Fac Allied Med Sci, Dept Clin Biochem, Mecca, Saudi Arabia.
   [Chrousos, George] Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Dept Pediat, GR-11527 Athens, Greece.
C3 King Abdulaziz University; King Abdulaziz University; King Saud Bin
   Abdulaziz University for Health Sciences; King Abdulaziz Medical City -
   Jeddah; Umm Al-Qura University; Athens Medical School; National &
   Kapodistrian University of Athens; The Aghia Sophia Children's Hospital
RP Borai, A (corresponding author), King Abdulaziz Univ, King Fahd Med Res Ctr, Saudi Diabet Study Res Grp, Jeddah 21413, Saudi Arabia.
EM boraiaa@ngha.med.sa
RI ABDULKHALIQ, ALTAF/JNE-7040-2023; AlShehri, Dhafer/B-5950-2015; Bahijri,
   Suhad/AAF-4141-2020; ajabnoor, ghada/H-5128-2012; Chrousos,
   George/G-8702-2011
OI ABDULKHALIQ, ALTAF AHMED/0000-0002-8148-1103; Bahijri,
   Suhad/0000-0001-6674-5409
FU deanship of research at King Abdulaziz University - Jeddah-Kingdom of
   Saudi Arabia [HiCi/1432-6-2]
FX This study was supported by the deanship of research at King Abdulaziz
   University - Jeddah-Kingdom of Saudi Arabia under grant number
   (HiCi/1432-6-2) as part of a main research project conducted by "Saudi
   Diabetes Study Research Group''. The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
CR ALHADRAMY MS, 1988, EUR J CLIN NUTR, V42, P359
   [Anonymous], P 8 HAW INT C ARTS H
   Asher G, 2008, CELL, V134, P317, DOI 10.1016/j.cell.2008.06.050
   Bao AM, 2008, BRAIN RES REV, V57, P531, DOI 10.1016/j.brainresrev.2007.04.005
   Ben Salem L, 2002, ANN ENDOCRINOL-PARIS, V63, P497
   Charmandari E, 2005, ANNU REV PHYSIOL, V67, P259, DOI 10.1146/annurev.physiol.67.040403.120816
   Charmandari E, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025612
   Chrousos G, 2001, Endocrinology and Metabolism, DOI DOI 10.1126/STKE.3042005PE48
   Chrousos George P, 2005, Sci STKE, V2005, ppe48, DOI 10.1126/stke.3042005pe48
   Eng J, 2003, RADIOLOGY, V227, P309, DOI 10.1148/radiol.2272012051
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Friedman TC, 1996, ENDOCR J, V43, P645, DOI 10.1507/endocrj.43.645
   Froy O, 2010, AGING-US, V2, P7, DOI 10.18632/aging.100116
   Hirayama J, 2007, NATURE, V450, P1086, DOI 10.1038/nature06394
   Kino T., 2005, TEC BEHAV N 1, P295, DOI 10.1016/S0921-0709(05)80017-3
   Kino T, 2011, ENDOCR DEV, V20, P116, DOI 10.1159/000321232
   Kluge M, 2007, J PSYCHIATR RES, V41, P928, DOI 10.1016/j.jpsychires.2006.08.005
   Knutson KL, 2007, SLEEP MED REV, V11, P163, DOI 10.1016/j.smrv.2007.01.002
   Knutsson A, 1989, Scand J Soc Med Suppl, V44, P1
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Maurovich-Horvat E, 2008, Prague Med Rep, V109, P275
   Nader N, 2010, TRENDS ENDOCRIN MET, V21, P277, DOI 10.1016/j.tem.2009.12.011
   Nader N, 2009, FASEB J, V23, P1572, DOI 10.1096/fj.08-117697
   Nakahata Y, 2008, CELL, V134, P329, DOI 10.1016/j.cell.2008.07.002
   Paslakis G, 2011, PSYCHONEUROENDOCRINO, V36, P691, DOI 10.1016/j.psyneuen.2010.10.002
   Pervanidou P, 2012, METABOLISM, V61, P611, DOI 10.1016/j.metabol.2011.10.005
   Russ SJ, 2012, PSYCHONEUROENDOCRINO, V37, P462, DOI 10.1016/j.psyneuen.2011.07.014
   Scheer FAJL, 2009, P NATL ACAD SCI USA, V106, P4453, DOI 10.1073/pnas.0808180106
   Shearer WT, 2001, J ALLERGY CLIN IMMUN, V107, P165, DOI 10.1067/mai.2001.112270
   Suwazono Y, 2008, OBESITY, V16, P1887, DOI 10.1038/oby.2008.298
   Van Cauter E, 2007, HORM RES, V67, P2, DOI 10.1159/000097543
NR 31
TC 71
Z9 74
U1 2
U2 16
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 18
PY 2013
VL 8
IS 4
AR e60917
DI 10.1371/journal.pone.0060917
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 130IU
UT WOS:000317908700010
PM 23637777
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Miles, LW
   Williams, N
   Luthy, KE
   Eden, L
AF Miles, Leslie W.
   Williams, Nathalia
   Luthy, Karlen E.
   Eden, Lacey
TI Adult Vaccination Rates in the Mentally Ill Population: An Outpatient
   Improvement Project
SO JOURNAL OF THE AMERICAN PSYCHIATRIC NURSES ASSOCIATION
LA English
DT Article
DE health services; patient satisfaction; quantitative research; serious
   mental illness
ID METABOLIC SYNDROME; IMMUNIZATION; ILLNESS; HEALTH; CARE; PEOPLE;
   SCHIZOPHRENIA; OLDER; NEED
AB Background: Adults who suffer with severe and persistent mental illness (SPMI) rarely access medical care to receive preventive vaccines. Aims: To increase the rate of vaccines among the SPMI population in an outpatient community mental health center (CMHC). Methods: A review of the literature identified a gap between the general population and SPMI clients in receiving preventive vaccinations. An initial mixed-method convenience survey of SPMI clients (n = 392) provided information on current vaccination status, demographics, beliefs, and interest in receiving vaccines. A vaccination program was developed to address identified barriers and increase vaccination rates. Postintervention data were collected through a mixed-method convenience survey of SPMI clients (n = 60) who participated in immunizations clinics to evaluate client satisfaction. A partnership between the health department and CMHC was developed to deliver vaccines in a nontraditional site. Vaccines administered included annual influenza; hepatitis A; hepatitis B; herpes zoster; measles, mumps, and rubella; pneumococcal; and tetanus, diphtheria, and pertussis (Tdap). Results: More than 1,000 vaccines were administered in the first 8 months, with a significant increase in vaccination rates over baseline for individual vaccines ranging from 18.75% to 83%. Postintervention survey results found a 95% satisfaction rate. Conclusions: Implementation of a vaccination program in a nontraditional site that facilitates access for SPMI clients can promote an overwhelming increase in the vaccination rates for this underserved population. Results suggest that the integration of mental health and CMHC services can have a profound positive effect on SPMI population health.
C1 [Miles, Leslie W.; Williams, Nathalia; Luthy, Karlen E.; Eden, Lacey] Brigham Young Univ, 500 KMBL, Provo, UT 84602 USA.
C3 Brigham Young University
RP Miles, LW (corresponding author), Brigham Young Univ, 500 KMBL, Provo, UT 84602 USA.
EM leslie-miles@byu.edu
OI Miles, Leslie/0000-0002-1964-8929
CR Alpert PT, 2015, HOME HLTH CARE MAN P, V27, P41, DOI 10.1177/1084822314537071
   Breivik Harald, 2015, J Pain Palliat Care Pharmacother, V29, P187, DOI 10.3109/15360288.2015.1037525
   Bridges CB, 2014, MMWR-MORBID MORTAL W, V63, P110
   Carney CP, 2006, J GEN INTERN MED, V21, P1133, DOI 10.1111/j.1525-1497.2006.00563.x
   Carrà G, 2014, SOC PSYCH PSYCH EPID, V49, P1739, DOI 10.1007/s00127-014-0835-y
   Castillo EG, 2015, J AM PSYCHIAT NURSES, V21, P233, DOI 10.1177/1078390315598607
   Centers for Disease Control and Prevention, 2011, VACC INF STAT
   Centers for Disease Control and Prevention, 2019, AD VACC RES AD VACC
   Centers for Disease Control and Prevention, 2016, GUID PUBL IMM MAN
   Centers for Disease Control and Prevention, 2012, ADV COMM IMM PRACT M
   Centers for Disease Control and Prevention, 2008, VACC COV US AD NAT I
   Centers for Medicare and Medicaid Services, 2018, IMM
   Clubhouse International, 2016, WHAT WE DO
   Decoux Michelle, 2005, Issues Ment Health Nurs, V26, P935, DOI 10.1080/01612840500248221
   Druss BG, 2008, PSYCHIAT SERV, V59, P917, DOI 10.1176/ps.2008.59.8.917
   Goad JA, 2013, ANN FAM MED, V11, P429, DOI 10.1370/afm.1542
   Iltis AS, 2013, JAMA PSYCHIAT, V70, P1363, DOI 10.1001/jamapsychiatry.2013.2105
   Jeste DV, 2006, SCHIZOPHRENIA BULL, V32, P121
   Johnson DR, 2008, AM J MED, V121, pS28, DOI 10.1016/j.amjmed.2008.05.005
   Kaufman Erin Anne, 2012, Issues Ment Health Nurs, V33, P172, DOI 10.3109/01612840.2011.638415
   Lin MT, 2012, SOC PSYCH PSYCH EPID, V47, P939, DOI 10.1007/s00127-011-0401-9
   Lorenz RA, 2013, INT J PSYCHIAT MED, V46, P1, DOI 10.2190/PM.46.1.a
   Mangurian C, 2013, PSYCHIAT SERV, V64, P597, DOI 10.1176/appi.ps.002542012
   National Foundation for Infectious Diseases, 2008, SAV LIV INT VACC AD
   National Institute of Mental Health, 2014, SER MENT ILLN US AD
   Ngamruengphong S, 2015, SOUTH MED J, V108, P510, DOI 10.14423/SMJ.0000000000000334
   Nuorti J. P., 2010, Morbidity and Mortality Weekly Report, V59, P1102
   Rittle C, 2014, WORKPLACE HEALTH SAF, V62, P468, DOI 10.3928/21650799-20140909-01
   Rockwell PG, 2015, J FAM PRACTICE, V64, P625
   Savoy M, 2016, AM FAM PHYSICIAN, V93, P317
   Seminog OO, 2013, THORAX, V68, P171, DOI 10.1136/thoraxjnl-2012-202480
   Shefer A, 1999, EPIDEMIOL REV, V21, P96, DOI 10.1093/oxfordjournals.epirev.a017992
   Sowers W, 2016, COMMUNITY MENT HLT J, V52, P379, DOI 10.1007/s10597-015-9983-0
   Tosh G, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008567.pub3
   U. S. Department of Health and Human Services-Office of Disease Prevention and a. Health Promotion, 2017, HLTH PEOPL 2020 IMM
   Utah Bureau of Epidemiology, 2012, PERT WEEKL SUMM
   van Hasselt FM, 2015, INT J METH PSYCH RES, V24, P83, DOI 10.1002/mpr.1456
   van Hasselt FM, 2013, BMC HEALTH SERV RES, V13, DOI 10.1186/1472-6963-13-426
   van Hasselt FM, 2013, INT J MENT HEALTH NU, V22, P249, DOI 10.1111/j.1447-0349.2012.00859.x
   Williams WW, 2016, MMWR SURVEILL SUMM, V65, P1, DOI 10.15585/mmwr.ss6501a1
   Wright-Berryman JL, 2016, J SOC SERV RES, V42, P281, DOI 10.1080/01488376.2015.1093580
NR 41
TC 56
Z9 57
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1078-3903
EI 1532-5725
J9 J AM PSYCHIAT NURSES
JI J. Am. Psych. Nurses Assoc.
PD MAR
PY 2020
VL 26
IS 2
BP 172
EP 180
DI 10.1177/1078390319831763
PG 9
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA LA3KY
UT WOS:000523850500006
PM 30866701
DA 2025-06-11
ER

PT J
AU Varga, B
   Kassai, F
   Szabó, G
   Kovács, P
   Fischer, J
   Gyertyán, I
AF Varga, Balazs
   Kassai, Ferenc
   Szabo, Gyorgy
   Kovacs, Peter
   Fischer, Janos
   Gyertyan, Istvan
TI Pharmacological comparison of traditional and non-traditional
   cannabinoid receptor 1 blockers in rodent models in vivo
SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
LA English
DT Article
DE Cannabinoid; Antagonist; Pharmacological; Comparison; Obesity; Anxiety
ID CB1 RECEPTOR; FOOD-INTAKE; ULTRASONIC VOCALIZATION; ANTAGONIST
   RIMONABANT; EMOTIONAL REACTIVITY; SELECTIVE ANTAGONIST;
   METABOLIC-DISORDERS; LEPTIN RESISTANCE; INVERSE AGONISM; ANXIETY-LIKE
AB Cannabinoid receptor 1 (CB1R) antagonists have been proven to be effective anti-obesity drugs; however, psychiatric side effects have halted their pharmaceutical development worldwide. Despite the emergence of next generation CB1R blockers, a preclinical head to head comparison of the anti-obesity and psychiatric side effect profiles of the key compounds has not been performed. Here, we compared classical CB1R antagonists (rimonabant, taranabant, otenabant, ibipinabant, and surinabant) and non-traditional CB1R blockers (the partial agonist 0-1269, the neutral antagonists VCHSR and LH-21 and the peripherally acting inverse agonist JD-5037) using an in vivo screening cascade. First, the potencies of these compounds to reduce CB1R agonist-induced hypothermia and decrease fasting-induced food intake were determined. Then, equipotent doses of the non-toxic compounds were compared in a diet-induced obesity (DIO) test, which includes measurements of metabolic syndrome markers. Psychiatric side effects were assessed by measuring anxiogenicity in an ultrasonic vocalization test. All classical CB1R blockers were centrally acting appetite suppressants and decreased body weight and food intake in an obesity-dependent manner, with only slight effects on metabolic syndrome markers. In addition, all classical CB1R blockers increased ultrasonic vocalization. Surprisingly, none of the non-classical CB1R blockers was eligible for the DIO comparison and side effect profiling. 0-1269 and LH-21 induced convulsive behavior, whereas VCHSR and JD-5037 were devoid of any in vivo activity. The classical CB1R blockers displayed similar therapeutic and side effect profiles in vivo, whereas the available non-traditional CB1R blockers were not appropriate tools for testing the therapeutic potential of alternative CB1R inhibitors.
C1 [Varga, Balazs; Kassai, Ferenc; Szabo, Gyorgy; Kovacs, Peter; Fischer, Janos; Gyertyan, Istvan] Gedeon Richter Plc, 10,POB 27, H-1475 Budapest, Hungary.
   [Kassai, Ferenc; Gyertyan, Istvan] Semmelweis Univ, Dept Pharmacol & Pharmacotherapy, MTA SE NAP Cognit Translat Behav Pharmacol Grp B, Nagyvarad Ter 4, H-1089 Budapest, Hungary.
   [Kassai, Ferenc; Gyertyan, Istvan] Hungarian Acad Sci, Res Ctr Nat Sci, Inst Cognit Neurosci & Psychol, Magyar Tudosok Korutja 2, H-1117 Budapest, Hungary.
   [Kovacs, Peter] Berlin Chem A Menarini Magyarorszag Kft, Neumann Janos U 1, H-2040 Budaors, Hungary.
C3 Gedeon Richter Chemistry Works; Semmelweis University; Hungarian Academy
   of Sciences; HUN-REN; HUN-REN Research Centre for Natural Sciences;
   Institute of Cognitive Neuroscience & Psychology - HAS
RP Varga, B (corresponding author), Gedeon Richter Plc, Gyomroi Ut 19-21, H-1103 Budapest, Hungary.
EM b.varga@richter.hu
RI Varga, Balázs/K-5637-2019; Gyertyan, Istvan/K-2174-2017
OI Kovacs, Peter/0000-0001-5732-7432; Gyertyan, Istvan/0000-0002-5727-1974;
   Varga, Balazs/0000-0002-2925-7868
FU Gedeon Richter Plc
FX The study was funded by Gedeon Richter Plc.
CR [Anonymous], AM J PHYSL REGUL INT
   Bellocchio L, 2006, CURR OPIN PHARMACOL, V6, P586, DOI 10.1016/j.coph.2006.09.001
   Beyer CE, 2010, NEUROBIOL DIS, V39, P148, DOI 10.1016/j.nbd.2010.03.020
   BUCKETT WR, 1988, PROG NEURO-PSYCHOPH, V12, P575, DOI 10.1016/0278-5846(88)90003-6
   Chen RZ, 2008, EUR J PHARMACOL, V584, P338, DOI 10.1016/j.ejphar.2008.02.029
   Chorvat RJ, 2013, BIOORG MED CHEM LETT, V23, P4751, DOI 10.1016/j.bmcl.2013.06.066
   Chorvat RJ, 2012, BIOORG MED CHEM LETT, V22, P6173, DOI 10.1016/j.bmcl.2012.08.004
   Colombo G, 1998, LIFE SCI, V63, pPL113, DOI 10.1016/S0024-3205(98)00322-1
   Cota D, 2009, OBESITY, V17, P1641, DOI 10.1038/oby.2009.84
   De Ross J, 2008, PROG NEURO-PSYCHOPH, V32, P794, DOI 10.1016/j.pnpbp.2007.12.013
   Doggrell SA, 2005, EXPERT OPIN INV DRUG, V14, P339, DOI 10.1517/13543784.14.3.339
   Erkekoglu P., 2008, FABAD J PHARM SCI, V33, P95
   Fong TM, 2008, EXPERT OPIN INV DRUG, V17, P321, DOI [10.1517/13543784.17.3.321, 10.1517/13543784.17.3.321 ]
   Fong TM, 2007, J PHARMACOL EXP THER, V321, P1013, DOI 10.1124/jpet.106.118737
   Gamble-George JC, 2013, PSYCHOPHARMACOLOGY, V228, P401, DOI 10.1007/s00213-013-3042-8
   Gómez R, 2002, J NEUROSCI, V22, P9612
   Griebel G, 2005, BIOL PSYCHIAT, V57, P261, DOI 10.1016/j.biopsych.2004.10.032
   Griffith DA, 2009, J MED CHEM, V52, P234, DOI 10.1021/jm8012932
   Hadcock JR, 2010, BIOCHEM BIOPH RES CO, V394, P366, DOI 10.1016/j.bbrc.2010.03.015
   Haller J, 2007, EUR J NEUROSCI, V25, P2445, DOI 10.1111/j.1460-9568.2007.05476.x
   Haller J, 2004, EUR J NEUROSCI, V19, P1906, DOI 10.1111/j.1460-9568.2004.03293.x
   Haller J, 2002, EUR J NEUROSCI, V16, P1395, DOI 10.1046/j.1460-9568.2002.02192.x
   Heal DJ, 2009, BRIT J CLIN PHARMACO, V68, P861, DOI 10.1111/j.1365-2125.2009.03549.x
   Huang P, 2010, NEUROSCI LETT, V475, P165, DOI 10.1016/j.neulet.2010.03.071
   Jagerovic N, 2004, J MED CHEM, V47, P2939, DOI 10.1021/jm031099y
   Janero DR, 2009, EXPERT OPIN EMERG DR, V14, P43, DOI [10.1517/14728210902736568 , 10.1517/14728210902736568]
   Jbilo O, 2005, FASEB J, V19, P1567, DOI 10.1096/fj.04-3177fje
   Jelen P, 2003, BEHAV BRAIN RES, V141, P63, DOI 10.1016/S0166-4328(02)00321-2
   Kassai F, 2012, PROG NEURO-PSYCHOPH, V36, P128, DOI 10.1016/j.pnpbp.2011.10.012
   Kirkham TC, 2002, BRIT J PHARMACOL, V136, P550, DOI 10.1038/sj.bjp.0704767
   Kroes RA, 2007, BEHAV BRAIN RES, V182, P290, DOI 10.1016/j.bbr.2007.03.022
   Lange JHM, 2005, BIOORG MED CHEM LETT, V15, P4794, DOI 10.1016/j.bmcl.2005.07.054
   Lange JHM, 2004, J MED CHEM, V47, P627, DOI 10.1021/jm031019q
   Le Foll B, 2009, PSYCHOPHARMACOLOGY, V205, P171, DOI 10.1007/s00213-009-1506-7
   Manca I, 2013, EUR J MED CHEM, V62, P256, DOI 10.1016/j.ejmech.2012.12.056
   Mashiko S, 2008, OBESITY, V16, P1510, DOI 10.1038/oby.2008.223
   Need AB, 2006, PSYCHOPHARMACOLOGY, V184, P26, DOI 10.1007/s00213-005-0234-x
   O'Keefe L, 2014, DIABETES OBES METAB, V16, P294, DOI 10.1111/dom.12144
   Osei-Hyiaman D, 2008, J CLIN INVEST, V118, P3160, DOI 10.1172/JCI34827
   Pacher P, 2006, PHARMACOL REV, V58, P389, DOI 10.1124/pr.58.3.2
   Pavon FJ, 2006, NEUROPHARMACOLOGY, V51, P358, DOI 10.1016/j.neuropharm.2006.03.029
   Perio A, 1996, BEHAV PHARMACOL, V7, P65
   Pertwee RG, 2005, LIFE SCI, V76, P1307, DOI 10.1016/j.lfs.2004.10.025
   Rinaldi-Carmona M, 2004, J PHARMACOL EXP THER, V310, P905, DOI 10.1124/jpet.104.067884
   RINALDICARMONA M, 1994, FEBS LETT, V350, P240, DOI 10.1016/0014-5793(94)00773-X
   Roche M, 2007, EUR J NEUROSCI, V26, P2643, DOI 10.1111/j.1460-9568.2007.05861.x
   Rodgers RJ, 2003, EUR J NEUROSCI, V17, P1279, DOI 10.1046/j.1460-9568.2003.02548.x
   Rohrbach K, 2012, DIABETES OBES METAB, V14, P555, DOI 10.1111/j.1463-1326.2012.01563.x
   Sharma MK, 2014, EUR J MED CHEM, V79, P298, DOI 10.1016/j.ejmech.2014.04.011
   Silvestri C, 2012, EXPERT OPIN INV DRUG, V21, P1309, DOI 10.1517/13543784.2012.704019
   Son MH, 2010, INT J OBESITY, V34, P547, DOI 10.1038/ijo.2009.253
   SUGRUE MF, 1987, PHARMACOL THERAPEUT, V32, P145, DOI 10.1016/0163-7258(87)90057-X
   Szabó G, 2009, J MED CHEM, V52, P4329, DOI 10.1021/jm900179y
   Tam J, 2012, CELL METAB, V16, P167, DOI 10.1016/j.cmet.2012.07.002
   Tam J, 2010, J CLIN INVEST, V120, P2953, DOI 10.1172/JCI42551
   Thornton-Jones ZD, 2006, PHARMACOL BIOCHEM BE, V84, P353, DOI 10.1016/j.pbb.2006.06.001
   Varga B, 2012, PHARMACOL BIOCHEM BE, V103, P425, DOI 10.1016/j.pbb.2012.09.016
   Ward SJ, 2011, OBESITY, V19, P1325, DOI 10.1038/oby.2011.69
   Wiley JL, 2005, BRIT J PHARMACOL, V145, P293, DOI 10.1038/sj.bjp.0706157
   Wiley JL, 2001, J PHARMACOL EXP THER, V296, P1013
NR 60
TC 5
Z9 5
U1 1
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0091-3057
J9 PHARMACOL BIOCHEM BE
JI Pharmacol. Biochem. Behav.
PD AUG
PY 2017
VL 159
BP 24
EP 35
DI 10.1016/j.pbb.2017.06.012
PG 12
WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy
GA FE4IS
UT WOS:000408178200005
PM 28666894
DA 2025-06-11
ER

PT S
AU Woodward, A
   Klonizakis, M
   Broom, D
AF Woodward, Amie
   Klonizakis, Markos
   Broom, David
BE Xiao, J
TI Exercise and Polycystic Ovary Syndrome
SO PHYSICAL EXERCISE FOR HUMAN HEALTH
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
DE Polycystic ovary syndrome; Exercise; Physical activity; Reproductive
   health; Cardiovascular disease
ID CARDIOVASCULAR-DISEASE RISK; OBSTRUCTIVE SLEEP-APNEA;
   INSULIN-RESISTANCE; OBESE WOMEN; MENTAL-HEALTH; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; AEROBIC EXERCISE; TRAINING-PROGRAM; ANDROGEN EXCESS
AB Polycystic ovary syndrome (PCOS) is a complex endocrinopathy affecting both the metabolism and reproductive system of women of reproductive age. Prevalence ranges from 6.1-19.9% depending on the criteria used to give a diagnosis. PCOS accounts for approximately 80% of women with anovulatory infertility, and causes disruption at various stages of the reproductive axis. Evidence suggests lifestyle modification should be the first line of therapy for women with PCOS. Several studies have examined the impact of exercise interventions on reproductive function, with results indicating improvements in menstrual and/or ovulation frequency following exercise. Enhanced insulin sensitivity underpins the mechanisms of how exercise restores reproductive function. Women with PCOS typically have a cluster of metabolic abnormalities that are risk factors for CVD. There is irrefutable evidence that exercise mitigates CVD risk factors in women with PCOS. The mechanism by which exercise improves many CVD risk factors is again associated with improved insulin sensitivity and decreased hyperinsulinemia. In addition to cardiometabolic and reproductive complications, PCOS has been associated with an increased prevalence of mental health disorders. Exercise improves psychological well-being in women with PCOS, dependent on certain physiological factors. An optimal dose-response relationship to exercise in PCOS may not be feasible because of the highly individualised characteristics of the disorder. Guidelines for PCOS suggest at least 150 min of physical activity per week. Evidence confirms that this should form the basis of any clinician or healthcare professional prescription.
C1 [Woodward, Amie; Klonizakis, Markos; Broom, David] Sheffield Hallam Univ, Ctr Sport & Exercise Sci, Fac Hlth & Wellbeing, Sheffield, S Yorkshire, England.
C3 Sheffield Hallam University
RP Broom, D (corresponding author), Sheffield Hallam Univ, Ctr Sport & Exercise Sci, Fac Hlth & Wellbeing, Sheffield, S Yorkshire, England.
EM d.r.broom@shu.ac.uk
RI Woodward, Amie/LUZ-5979-2024; Klonizakis, Markos/A-3680-2009
OI Klonizakis, Markos/0000-0002-8864-4403; Woodward,
   Amie/0000-0002-9579-4012; Broom, David/0000-0002-0305-937X
CR Adams JM, 2004, J CLIN ENDOCR METAB, V89, P4343, DOI 10.1210/jc.2003-031600
   Amer SA, 2013, REPROD BIOL ENDOCRIN, V11, DOI 10.1186/1477-7827-11-115
   [Anonymous], 2013, EvidenceBased Complementary and Alternative Medicine
   [Anonymous], 1992, POLYCYSTIC OVARY SYN
   Aye MM, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00592
   Azziz R, 2004, J CLIN ENDOCR METAB, V89, P2745, DOI 10.1210/jc.2003-032046
   Azziz R, 2006, J CLIN ENDOCR METAB, V91, P4237, DOI 10.1210/jc.2006-0178
   Azziz R, 2009, FERTIL STERIL, V91, P456, DOI 10.1016/j.fertnstert.2008.06.035
   Banting LK, 2014, BMC WOMENS HEALTH, V14, DOI 10.1186/1472-6874-14-51
   Baptiste CG, 2010, J STEROID BIOCHEM, V122, P42, DOI 10.1016/j.jsbmb.2009.12.010
   Beavers KM, 2010, CLIN CHIM ACTA, V411, P785, DOI 10.1016/j.cca.2010.02.069
   Benham JL, 2018, CLIN OBES, V8, P275, DOI 10.1111/cob.12258
   Benson S, 2009, PSYCHONEUROENDOCRINO, V34, P727, DOI 10.1016/j.psyneuen.2008.12.001
   Blay SL, 2016, NEUROPSYCH DIS TREAT, V12, P2895, DOI 10.2147/NDT.S91700
   Brown AJ, 2009, MED SCI SPORT EXER, V41, P497, DOI 10.1249/MSS.0b013e31818c6c0c
   BROWN JD, 1988, HEALTH PSYCHOL, V7, P341, DOI 10.1037/0278-6133.7.4.341
   Burks HR, 2014, Polycystic Ovary Syndrome, P3, DOI [10.1007/978-1-4614-8394-6_1/TABLES/2, DOI 10.1007/978-1-4614-8394-6_1/TABLES/2, DOI 10.1007/978-1-4614-8394-6_1]
   BYRNE A, 1993, J PSYCHOSOM RES, V37, P565, DOI 10.1016/0022-3999(93)90050-P
   Çakiroglu Y, 2016, J ENDOCRINOL INVEST, V39, P899, DOI 10.1007/s40618-016-0446-4
   Calan M, 2016, ENDOCR RES, V41, P261, DOI 10.3109/07435800.2015.1135442
   Calan M, 2016, ENDOCRINE, V53, P271, DOI 10.1007/s12020-016-0875-z
   Carmina E, 2004, FERTIL STERIL, V82, P661, DOI 10.1016/j.fertnstert.2004.01.041
   Carmina E, 2007, J CLIN ENDOCR METAB, V92, P2500, DOI 10.1210/jc.2006-2725
   Carpentier AC, 2008, DIABETES METAB, V34, P97, DOI 10.1016/j.diabet.2007.10.009
   Carroll S, 2004, SPORTS MED, V34, P371, DOI 10.2165/00007256-200434060-00004
   Cheema BS, 2014, SPORTS MED, V44, P1197, DOI 10.1007/s40279-014-0206-6
   Conte F, 2015, SPORTS MED, V45, P497, DOI 10.1007/s40279-014-0291-6
   Covington JD, 2016, BIOCHIMIE, V124, P27, DOI 10.1016/j.biochi.2014.10.028
   Dantzer R, 2001, BRAIN BEHAV IMMUN, V15, P7, DOI 10.1006/brbi.2000.0613
   Davari-Tanha Fatemeh, 2014, Acta Med Iran, V52, P46
   Dewailly D, 2016, BEST PRACT RES CL OB, V37, P5, DOI 10.1016/j.bpobgyn.2016.03.009
   DiLorenzo TM, 1999, PREV MED, V28, P75, DOI 10.1006/pmed.1998.0385
   Dokras A, 2013, STEROIDS, V78, P773, DOI 10.1016/j.steroids.2013.04.009
   Domecq JP, 2013, J CLIN ENDOCR METAB, V98, P4655, DOI 10.1210/jc.2013-2385
   Duleba AJ, 2012, FERTIL STERIL, V97, P7, DOI 10.1016/j.fertnstert.2011.11.023
   Durstine JL, 2001, SPORTS MED, V31, P1033, DOI 10.2165/00007256-200131150-00002
   Fleshner M, 2005, EXERC SPORT SCI REV, V33, P120
   Fontaine KR, 1999, QUAL LIFE RES, V8, P275, DOI 10.1023/A:1008835602894
   Galletly C, 2007, APPETITE, V49, P590, DOI 10.1016/j.appet.2007.03.222
   Gambineri A, 2002, INT J OBESITY, V26, P883, DOI 10.1038/sj.ijo.0801994
   Giallauria F, 2008, CLIN ENDOCRINOL, V69, P792, DOI 10.1111/j.1365-2265.2008.03305.x
   Gill S., 2014, Polycystic ovary syndrome: Current and emerging concepts, P81
   Ginsberg HN, 2005, ARCH MED RES, V36, P232, DOI 10.1016/j.arcmed.2005.01.005
   González F, 2012, STEROIDS, V77, P300, DOI 10.1016/j.steroids.2011.12.003
   Hachmi LBS, 2006, ARCH MAL COEUR VAISS, V99, P687
   Hagberg JM, 2000, SPORTS MED, V30, P193, DOI 10.2165/00007256-200030030-00004
   Halverstadt A, 2007, METABOLISM, V56, P444, DOI 10.1016/j.metabol.2006.10.019
   Harrison CL, 2012, CLIN ENDOCRINOL, V76, P351, DOI 10.1111/j.1365-2265.2011.04160.x
   Harrison CL, 2011, HUM REPROD UPDATE, V17, P171, DOI 10.1093/humupd/dmq045
   Himelein MJ, 2006, OBSTET GYNECOL SURV, V61, P723, DOI 10.1097/01.ogx.0000243772.33357.84
   Hussain A, 2015, INDIAN J PSYCHOL MED, V37, P66, DOI 10.4103/0253-7176.150822
   Hutchison SK, 2011, J CLIN ENDOCR METAB, V96, pE48, DOI 10.1210/jc.2010-0828
   Janssen I, 2004, AM J CLIN NUTR, V79, P379
   Joham AE, 2016, SEMIN REPROD MED, V34, P93, DOI 10.1055/s-0035-1571195
   Joham AE, 2015, AM J HYPERTENS, V28, P847, DOI 10.1093/ajh/hpu251
   Katzmarzyk PT, 2003, MED SCI SPORT EXER, V35, P1703, DOI 10.1249/01.MSS.0000089337.73244.9B
   Kaukua J, 2003, INT J OBESITY, V27, P1072, DOI 10.1038/sj.ijo.0802366
   Kerchner A, 2009, FERTIL STERIL, V91, P207, DOI 10.1016/j.fertnstert.2007.11.022
   Khani B, 2014, IRAN J REPROD MED, V12, P73
   Kim Jin Ju, 2013, Obstet Gynecol Sci, V56, P137
   Krystock A., 2014, Polycystic Ovary Syndrome: Current and Emerging Concepts, P147, DOI [DOI 10.1007/978-1-4614-8394-6_9, 10.1007/978-1-4614-8394-6_9]
   Ladson G, 2011, FERTIL STERIL, V95, P6
   Ladson G, 2011, FERTIL STERIL, V95, P1059, DOI 10.1016/j.fertnstert.2010.12.002
   Lamb JD, 2001, AM J OBSTET GYNECOL, V204, P6
   Legro R.S., 2000, ENDOTEXT S DARTMOUTH
   Legro RS, 2012, SEMIN REPROD MED, V30, P496, DOI 10.1055/s-0032-1328878
   Liao LM, 2008, GYNECOL ENDOCRINOL, V24, P555, DOI 10.1080/09513590802288226
   Mahoney D, 2014, J AM ASSOC NURSE PRA, V26, P301, DOI 10.1002/2327-6924.12073
   Mann S, 2014, SPORTS MED, V44, P211, DOI 10.1007/s40279-013-0110-5
   March WA, 2010, HUM REPROD, V25, P544, DOI 10.1093/humrep/dep399
   McCartney CR, 2002, SEMIN REPROD MED, V20, P317, DOI 10.1055/s-2002-36706
   McDonnell R, 2017, WOMENS HEALTH, V13, P89, DOI 10.1177/1745505717731971
   Meyer ML, 2012, HUM REPROD UPDATE, V18, P112, DOI 10.1093/humupd/dmr046
   Moran LJ, 2009, FERTIL STERIL, V92, P1966, DOI 10.1016/j.fertnstert.2008.09.018
   Ndefo Uche Anadu, 2013, P T, V38, P336
   Nidhi Ram, 2012, Int J Yoga, V5, P112, DOI 10.4103/0973-6131.98223
   Norman RJ, 2004, HUM REPROD UPDATE, V10, P267, DOI 10.1093/humupd/dmh018
   Orio F, 2005, J CLIN ENDOCR METAB, V90, P2, DOI 10.1210/jc.2004-0628
   Palomba S, 2008, HUM REPROD, V23, P642, DOI 10.1093/humrep/dem391
   Papadakis G, 2017, MINERVA ENDOCRINOL, V42, P340, DOI 10.23736/S0391-1977.17.02609-8
   Pericleous P, 2018, BMJ OPEN SPORT EXERC, V4, DOI 10.1136/bmjsem-2018-000372
   Petersen KF, 2007, P NATL ACAD SCI USA, V104, P12587, DOI 10.1073/pnas.0705408104
   Richter EA, 2013, PHYSIOL REV, V93, P993, DOI 10.1152/physrev.00038.2012
   Romero-Corral A, 2010, CHEST, V137, P711, DOI 10.1378/chest.09-0360
   Rotterdam E-S, 2003, FERTIL STERIL, V81, P19
   Sadeeqa S, 2018, J PHARM BIOALLIED SC, V10, P55, DOI [10.4103/JPBS.JPBS_1_18, 10.4103/jpbs.JPBS_1_18]
   Sattar SA, 2006, FOOD MICROBIOL FOOD, P265
   Scaruffi E, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00185
   Senn JJ, 2002, DIABETES, V51, P3391, DOI 10.2337/diabetes.51.12.3391
   Sirmans SM, 2014, CLIN EPIDEMIOL, V6, P1, DOI 10.2147/CLEP.S37559
   Stanford KI, 2014, ADV PHYSIOL EDUC, V38, P308, DOI 10.1152/advan.00080.2014
   Stener-Victorin E, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-131
   Tan J, 2017, CHINESE MED J-PEKING, V130, P262, DOI 10.4103/0366-6999.198916
   Teede HJ, 2006, ENDOCRINE, V30, P45, DOI 10.1385/ENDO:30:1:45
   Teede HJ, 2011, MED J AUSTRALIA, V195, pS69, DOI 10.5694/mja11.10915
   Thomson RL, 2008, J CLIN ENDOCR METAB, V93, P3373, DOI 10.1210/jc.2008-0751
   Thomson RL, 2010, FERTIL STERIL, V94, P1812, DOI 10.1016/j.fertnstert.2009.11.001
   Torrealday S., 2014, Polycystic ovary syndrome: Current and emerging concepts pp, P205
   Tsutsumi R, 2009, ENDOCR J, V56, P729, DOI 10.1507/endocrj.K09E-185
   Vgontzas AN, 2001, J CLIN ENDOCR METAB, V86, P517, DOI 10.1210/jc.86.2.517
   Vigorito C, 2007, J CLIN ENDOCR METAB, V92, P1379, DOI 10.1210/jc.2006-2794
   Vizza L, 2016, BMC SPORTS SCI MED R, V8, DOI 10.1186/s13102-016-0039-8
   Walston JD, 2012, CURR OPIN RHEUMATOL, V24, P623, DOI 10.1097/BOR.0b013e328358d59b
   Wild RA, 2010, J CLIN ENDOCR METAB, V95, P2038, DOI 10.1210/jc.2009-2724
   Woo HY, 2012, ENDOCR J, V59, P781, DOI 10.1507/endocrj.EJ12-0055
   Yildiz BO, 2012, HUM REPROD, V27, P3067, DOI 10.1093/humrep/des232
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
   Zhou MS, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-12
NR 108
TC 32
Z9 33
U1 5
U2 42
PU SPRINGER-VERLAG SINGAPORE PTE LTD
PI SINGAPORE
PA 152 BEACH ROAD, #21-01/04 GATEWAY EAST, SINGAPORE, 189721, SINGAPORE
SN 0065-2598
EI 2214-8019
BN 978-981-15-1792-1; 978-981-15-1791-4
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2020
VL 1228
BP 123
EP 136
DI 10.1007/978-981-15-1792-1_8
D2 10.1007/978-981-15-1792-1
PG 14
WC Medicine, Research & Experimental; Physiology; Sport Sciences
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Physiology; Sport Sciences
GA BQ5AS
UT WOS:000596720900008
PM 32342454
DA 2025-06-11
ER

PT J
AU Yaribeygi, H
   Farrokhi, FR
   Butler, AE
   Sahebkar, A
AF Yaribeygi, Habib
   Farrokhi, Farin Rashid
   Butler, Alexandra E.
   Sahebkar, Amirhossein
TI Insulin resistance: Review of the underlying molecular mechanisms
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Review
DE diabetes mellitus; GLUT-4; insulin receptor substrate; insulin
   resistance; insulin sensitivity; insulin signaling; oxidative stress;
   TNF-alpha
ID ENDOPLASMIC-RETICULUM STRESS; OXIDATIVE STRESS; DIABETES-MELLITUS;
   ADIPOSE-TISSUE; MICE LACKING; TNF-ALPHA; ER-STRESS; METABOLIC
   CONSEQUENCES; TARGETED DISRUPTION; RECEPTOR ANTIBODIES
AB Most human cells utilize glucose as the primary substrate, cellular uptake requiring insulin. Insulin signaling is therefore critical for these tissues. However, decrease in insulin sensitivity due to the disruption of various molecular pathways causes insulin resistance (IR). IR underpins many metabolic disorders such as type 2 diabetes and metabolic syndrome, impairments in insulin signaling disrupting entry of glucose into the adipocytes, and skeletal muscle cells. Although the exact underlying cause of IR has not been fully elucidated, a number of major mechanisms, including oxidative stress, inflammation, insulin receptor mutations, endoplasmic reticulum stress, and mitochondrial dysfunction have been suggested. In this review, we consider the role these cellular mechanisms play in the development of IR.
C1 [Yaribeygi, Habib; Farrokhi, Farin Rashid] Shahid Beheshti Univ Med Sci, Chron Kidney Dis Res Ctr, Tehran, Iran.
   [Butler, Alexandra E.] Qatar Biomed Res Inst, Diabetes Res Ctr, Doha, Qatar.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran.
C3 Shahid Beheshti University Medical Sciences; Qatar Foundation (QF);
   Hamad Bin Khalifa University-Qatar; Qatar Biomedical Research Institute
   (QBRI); Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences; Mashhad University of Medical Sciences
RP Yaribeygi, H (corresponding author), Shahid Beheshti Univ Med Sci, Chron Kidney Dis Res Ctr, Tehran, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad 9177948564, Iran.
EM habib.yari@yahoo.com; sahebkara@mums.ac.ir
RI farokhi, farin/G-6473-2017; Sahebkar, Amirhossein/B-5124-2018;
   Yaribeygi, Habib/R-8998-2019
OI Yaribeygi, Habib/0000-0002-1706-6212; Butler,
   Alexandra/0000-0002-5762-3917
CR Aguirre V, 2002, J BIOL CHEM, V277, P1531, DOI 10.1074/jbc.M101521200
   Ahlqvist E, 2015, NAT REV NEPHROL, V11, P277, DOI 10.1038/nrneph.2015.37
   Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
   [Anonymous], J CELLULAR PHYSL
   Avruch J, 1998, MOL CELL BIOCHEM, V182, P31, DOI 10.1023/A:1006823109415
   Banhegyi G, 2007, ANN NY ACAD SCI, V1113, P58, DOI 10.1196/annals.1391.007
   BATARSEH H, 1988, CLIN EXP IMMUNOL, V71, P85
   Beeson M, 2003, DIABETES, V52, P1926, DOI 10.2337/diabetes.52.8.1926
   Boden G, 2008, DIABETES, V57, P2438, DOI 10.2337/db08-0604
   Chen Yu, 2015, Methods Mol Biol, V1298, P173, DOI 10.1007/978-1-4939-2569-8_14
   Cheng ZY, 2010, TRENDS ENDOCRIN MET, V21, P589, DOI 10.1016/j.tem.2010.06.005
   Copps KD, 2012, DIABETOLOGIA, V55, P2565, DOI 10.1007/s00125-012-2644-8
   Dandona P, 2004, TRENDS IMMUNOL, V25, P4, DOI 10.1016/j.it.2003.10.013
   De Wit S, 2008, DIABETES CARE, V31, P1224, DOI 10.2337/dc07-2013
   Eck MJ, 1996, CELL, V85, P695, DOI 10.1016/S0092-8674(00)81236-2
   Elchebly M, 1999, SCIENCE, V283, P1544, DOI 10.1126/science.283.5407.1544
   Elmarakby AA, 2012, CARDIOVASC THER, V30, P49, DOI 10.1111/j.1755-5922.2010.00218.x
   Evans JL, 2005, ANTIOXID REDOX SIGN, V7, P1040, DOI 10.1089/ars.2005.7.1040
   Færch K, 2016, DIABETES, V65, P3473, DOI 10.2337/db16-0240
   Fantuzzi G, 2005, J ALLERGY CLIN IMMUN, V115, P911, DOI 10.1016/j.jaci.2005.02.023
   FEINSTEIN R, 1993, J BIOL CHEM, V268, P26055
   FINK RI, 1983, J CLIN INVEST, V71, P1523, DOI 10.1172/JCI110908
   Flamment M, 2012, TRENDS ENDOCRIN MET, V23, P381, DOI 10.1016/j.tem.2012.06.003
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gailliot MT, 2007, PERS SOC PSYCHOL REV, V11, P303, DOI 10.1177/1088868307303030
   GOODYEAR LJ, 1995, J CLIN INVEST, V95, P2195, DOI 10.1172/JCI117909
   Hall JE., 2021, Guyton and Hall textbook of medical physiology, V14th
   Han J, 2013, NAT CELL BIOL, V15, P481, DOI 10.1038/ncb2738
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Ho CK, 2016, MOL GENET METAB, V119, P288, DOI 10.1016/j.ymgme.2016.09.007
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Huang SH, 2007, CELL METAB, V5, P237, DOI 10.1016/j.cmet.2007.03.006
   Hundal RS, 2002, J CLIN INVEST, V109, P1321, DOI 10.1172/JCI200214955
   Hurrle S, 2017, BIOMED J, V40, P257, DOI 10.1016/j.bj.2017.06.007
   JOHANSSON JO, 1995, METABOLISM, V44, P1126, DOI 10.1016/0026-0495(95)90004-7
   Kahn BB, 2000, J CLIN INVEST, V106, P473, DOI 10.1172/JCI10842
   Kahn SE, 2014, LANCET, V383, P1068, DOI 10.1016/S0140-6736(13)62154-6
   Kasuga A, 1999, J AUTOIMMUN, V12, P131, DOI 10.1006/jaut.1998.0261
   Kim YB, 1999, J CLIN INVEST, V104, P733, DOI 10.1172/JCI6928
   Kiselyov VV, 2009, MOL SYST BIOL, V5, DOI 10.1038/msb.2008.78
   Klaman LD, 2000, MOL CELL BIOL, V20, P5479, DOI 10.1128/MCB.20.15.5479-5489.2000
   Koeppen B.M., 2017, Berne and Levy Physiology E-Book
   KOHRT WM, 1993, DIABETES, V42, P273, DOI 10.2337/diabetes.42.2.273
   Kojima M, 2005, PHYSIOL REV, V85, P495, DOI 10.1152/physrev.00012.2004
   Koren S, 2007, BEST PRACT RES CL EN, V21, P621, DOI 10.1016/j.beem.2007.08.004
   Liu M, 2014, VITAM HORM, V95, P35, DOI 10.1016/B978-0-12-800174-5.00002-8
   MABERLY GF, 1982, DIABETOLOGIA, V23, P333
   Maiza JC, 2013, DIABETES CARE, V36, pE77, DOI 10.2337/dc12-2664
   Maraschin Jorge de Faria, 2012, Adv Exp Med Biol, V771, P12
   MISBIN RI, 1981, J CLIN ENDOCR METAB, V52, P177, DOI 10.1210/jcem-52-2-177
   Moraes-Vieira PM, 2016, DIABETES, V65, P1808, DOI 10.2337/db16-0221
   Moreira PI, 2010, METHODS MOL BIOL, V610, P419, DOI 10.1007/978-1-60327-029-8_25
   Nakatani Y, 2005, J BIOL CHEM, V280, P847, DOI 10.1074/jbc.M411860200
   Ogurtsova K, 2017, DIABETES RES CLIN PR, V128, P40, DOI 10.1016/j.diabres.2017.03.024
   Olatunbosun ST, 2017, INSULIN RESISTANCE
   Pan Y, 2015, EXP CLIN ENDOCR DIAB, V123, P170, DOI 10.1055/s-0034-1395658
   PAULSEN EP, 1979, DIABETES, V28, P640, DOI 10.2337/diabetes.28.7.640
   Peraldi P, 1998, MOL CELL BIOCHEM, V182, P169, DOI 10.1023/A:1006865715292
   Perry RJ, 2014, NATURE, V510, P84, DOI 10.1038/nature13478
   Petersen KF, 2002, J CLIN INVEST, V109, P1345, DOI 10.1172/JCI0215001
   Pöykkö SM, 2003, DIABETES, V52, P2546, DOI 10.2337/diabetes.52.10.2546
   Purnell JQ, 2003, J CLIN ENDOCR METAB, V88, P5747, DOI 10.1210/jc.2003-030513
   Rahmanto AS, 2010, FREE RADICAL BIO MED, V48, P1071, DOI 10.1016/j.freeradbiomed.2010.01.025
   Rains JL, 2011, FREE RADICAL BIO MED, V50, P567, DOI 10.1016/j.freeradbiomed.2010.12.006
   Ropelle ER, 2006, J PHYSIOL-LONDON, V577, P997, DOI 10.1113/jphysiol.2006.120006
   Rui LY, 2002, J BIOL CHEM, V277, P42394, DOI 10.1074/jbc.C200444200
   Rutter GA, 2015, BIOCHEM J, V466, P203, DOI 10.1042/BJ20141384
   Salvadó L, 2015, TRENDS ENDOCRIN MET, V26, P438, DOI 10.1016/j.tem.2015.05.007
   Samuel VT, 2016, J CLIN INVEST, V126, P12, DOI 10.1172/JCI77812
   SCHERER PE, 1995, J BIOL CHEM, V270, P26746, DOI 10.1074/jbc.270.45.26746
   SCHLESSINGER J, 1980, NATURE, V286, P729, DOI 10.1038/286729a0
   Sebastián D, 2012, P NATL ACAD SCI USA, V109, P5523, DOI 10.1073/pnas.1108220109
   Sesti G, 2006, BEST PRACT RES CL EN, V20, P665, DOI 10.1016/j.beem.2006.09.007
   Shimomura I, 1999, NATURE, V401, P73, DOI 10.1038/43448
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Skarulis MC, 2010, J CLIN ENDOCR METAB, V95, P256, DOI 10.1210/jc.2009-0543
   Smith U, 1999, ANN NY ACAD SCI, V892, P119, DOI 10.1111/j.1749-6632.1999.tb07790.x
   Song XM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0068516
   Sun C, 2007, CELL METAB, V6, P307, DOI 10.1016/j.cmet.2007.08.014
   TAMEMOTO H, 1994, NATURE, V372, P182, DOI 10.1038/372182a0
   Taniguchi CM, 2006, NAT REV MOL CELL BIO, V7, P85, DOI 10.1038/nrm1837
   TAYLOR SI, 1990, DIABETES CARE, V13, P257, DOI 10.2337/diacare.13.3.257
   Thota P, 2017, GYNECOL ENDOCRINOL, V33, P179, DOI 10.1080/09513590.2016.1273897
   Tilg H, 2008, MOL MED, V14, P222, DOI 10.2119/2007-00119.Tilg
   Topp BG, 2007, AM J PHYSIOL-ENDOC M, V293, pE1730, DOI 10.1152/ajpendo.00572.2007
   Uruska A, 2010, EXP CLIN ENDOCR DIAB, V118, P478, DOI 10.1055/s-0030-1249635
   Uysal KT, 1998, ENDOCRINOLOGY, V139, P4832, DOI 10.1210/en.139.12.4832
   Uysal KT, 1997, NATURE, V389, P610, DOI 10.1038/39335
   Ventre J, 1997, DIABETES, V46, P1526, DOI 10.2337/diabetes.46.9.1526
   Wandel S, 1995, N-S ARCH PHARMACOL, V353, P36
   Weiss M., 2014, Insulin biosynthesis, secretion
   Westermeier F, 2015, BBA-MOL CELL RES, V1853, P1113, DOI 10.1016/j.bbamcr.2015.02.005
   Wierzbicki AS, 2008, CURR MED RES OPIN, V24, P609, DOI 10.1185/030079908X272742
   Williamson MK, 2018, VIRUSES-BASEL, V10, DOI 10.3390/v10030114
   Xie H, 1996, AM J PHYSIOL-ENDOC M, V271, pE587, DOI 10.1152/ajpendo.1996.271.3.E587
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yang L, 2010, CELL METAB, V11, P467, DOI 10.1016/j.cmet.2010.04.005
   Yaribeygi H, 2018, J CELL BIOCHEM, V119, P6080, DOI 10.1002/jcb.26806
   Yenush L, 1996, J BIOL CHEM, V271, P24300, DOI 10.1074/jbc.271.39.24300
   Yip SC, 2010, TRENDS BIOCHEM SCI, V35, P442, DOI 10.1016/j.tibs.2010.03.004
   Yu IC, 2014, DIABETES, V63, P3180, DOI 10.2337/db13-1505
   Yuan MS, 2001, SCIENCE, V293, P1673, DOI 10.1126/science.1061620
   Zaccardi F, 2016, POSTGRAD MED J, V92, P63, DOI 10.1136/postgradmedj-2015-133281
NR 103
TC 594
Z9 651
U1 29
U2 535
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD JUN
PY 2019
VL 234
IS 6
BP 8152
EP 8161
DI 10.1002/jcp.27603
PG 10
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA HM2QU
UT WOS:000459314500044
PM 30317615
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Sloan, RP
   Shapiro, PA
   McKinley, PS
   Bartels, M
   Shimbo, D
   Lauriola, V
   Karmally, W
   Pavlicova, M
   Choi, CJ
   Choo, TH
   Scodes, JM
   Flood, P
   Tracey, KJ
AF Sloan, Richard P.
   Shapiro, Peter A.
   McKinley, Paula S.
   Bartels, Matthew
   Shimbo, Daichi
   Lauriola, Vincenzo
   Karmally, Wahida
   Pavlicova, Martina
   Choi, C. Jean
   Choo, Tse-Hwei
   Scodes, Jennifer M.
   Flood, Pamela
   Tracey, Kevin J.
TI Aerobic Exercise Training and Inducible Inflammation: Results of a
   Randomized Controlled Trial in Healthy, Young Adults
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE clinical trial; exercise training; inflammation
ID C-REACTIVE PROTEIN; BLOOD MONONUCLEAR-CELLS; PHYSICAL-ACTIVITY;
   WEIGHT-LOSS; GLUCOCORTICOID-RECEPTOR; DEPRESSIVE SYMPTOMS; OXIDATIVE
   STRESS; PSYCHOLOGICAL STRESS; METABOLIC SYNDROME; RISK-FACTORS
AB Background-Consensus panels regularly recommend aerobic exercise for its health-promoting properties, due in part to presumed anti-inflammatory effects, but many studies show no such effect, possibly related to study differences in participants, interventions, inflammatory markers, and statistical approaches. This variability makes an unequivocal determination of the anti-inflammatory effects of aerobic training elusive.
   Methods and Results-We conducted a randomized controlled trial of 12 weeks of aerobic exercise training or a wait list control condition followed by 4 weeks of sedentary deconditioning on lipopolysaccharide (0, 0.1, and 1.0 ng/mL)-inducible tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), and on toll-like receptor 4 in 119 healthy, sedentary young adults. Aerobic capacity by cardiopulmonary exercise testing was measured at study entry (T1) and after training (T2) and deconditioning (T3). Despite a 15% increase in maximal oxygen consumption, there were no changes in inflammatory markers. Additional analyses revealed a differential longitudinal aerobic exercise training effect by lipopolysaccharide level in inducible TNF-alpha (P=0.08) and IL-6 (P=0.011), showing T1 to T2 increases rather than decreases in inducible (lipopolysaccharide 0.1, 1.0 versus 0.0 ng/mL) TNF-alpha (51% increase, P=0.041) and IL-6 (42% increase, P=0.11), and significant T2 to T3 decreases in inducible TNF-alpha (54% decrease, P=0.007) and IL-6 (55% decrease, P<0.001). There were no significant changes in either group at the 0.0 ng/mL lipopolysaccharide level for TNF-alpha or IL-6.
   Conclusions-The failure to support the primary hypotheses and the unexpected post hoc findings of an exercise-training-induced proinflammatory response raise questions about whether and under what conditions exercise training has anti-inflammatory effects.
C1 [Sloan, Richard P.; McKinley, Paula S.; Lauriola, Vincenzo] Columbia Univ, Div Behav Med, Dept Psychiat, Mailman Sch Publ Hlth,Med Ctr, New York, NY USA.
   [Shapiro, Peter A.] Columbia Univ, Div Consultat Liaison Psychiat, Dept Psychiat, Mailman Sch Publ Hlth,Med Ctr, New York, NY USA.
   [Bartels, Matthew] Columbia Univ, Dept Rehabil Med, Mailman Sch Publ Hlth, Med Ctr, New York, NY USA.
   [Shimbo, Daichi] Columbia Univ, Dept Med, Mailman Sch Publ Hlth, Med Ctr, New York, NY USA.
   [Flood, Pamela] Columbia Univ, Dept Anesthesiol, Mailman Sch Publ Hlth, Med Ctr, New York, NY USA.
   [Pavlicova, Martina] Columbia Univ, Dept Biostat, Mailman Sch Publ Hlth, Med Ctr, New York, NY USA.
   [Karmally, Wahida] Columbia Univ, Irving Inst Clin & Translat Res, Med Ctr, New York, NY USA.
   [Sloan, Richard P.; Choi, C. Jean; Choo, Tse-Hwei; Scodes, Jennifer M.] New York State Psychiat Inst & Hosp, New York, NY 10032 USA.
   [Tracey, Kevin J.] Northwell Hlth, Feinstein Inst Med Res, Manhassett, NY USA.
   [McKinley, Paula S.] Montefiore Med Ctr, Div Gen Internal Med, Dept Med, 111 E 210th St, Bronx, NY 10467 USA.
   [Bartels, Matthew] Montefiore Med Ctr, Dept Rehabil Med, 111 E 210th St, Bronx, NY 10467 USA.
   [Flood, Pamela] Anesthesia Dept, Stanford, CA USA.
C3 Columbia University; Columbia University; Columbia University; Columbia
   University; Columbia University; Columbia University; Columbia
   University; New York State Psychiatry Institute; Northwell Health;
   Montefiore Medical Center; Albert Einstein College of Medicine;
   Montefiore Medical Center; Albert Einstein College of Medicine
RP Sloan, RP (corresponding author), Columbia Univ, Div Behav Med, Dept Psychiat, Med Ctr, 622 West 168th St, New York, NY 10032 USA.
EM rps7@columbia.edu
RI Pavlicova, Martina/ITU-3238-2023; Lauriola, Vincenzo/MCY-6392-2025;
   Flood, Pamela/C-2371-2019; McKinley, Paula/B-8666-2012
OI Flood, Pamela/0000-0001-7023-3924; Lauriola,
   Vincenzo/0000-0002-1761-7686; Tracey, Kevin J/0000-0003-1884-6314
FU National Heart, Lung, and Blood Institute (Sloan) [R01 HL094423]; NIH
   Center for Advancing Translational Sciences [UL1 TR001873]; Nathaniel
   Wharton Fund
FX This study was supported by Grant R01 HL094423 from the National Heart,
   Lung, and Blood Institute (Sloan), Grant UL1 TR001873 from the NIH
   Center for Advancing Translational Sciences, and the Nathaniel Wharton
   Fund.
CR Aschbacher K, 2013, PSYCHONEUROENDOCRINO, V38, P1698, DOI 10.1016/j.psyneuen.2013.02.004
   Auerbach P, 2013, AM J PHYSIOL-REG I, V305, pR490, DOI 10.1152/ajpregu.00575.2012
   Bladbjerg EM, 2011, BRIT J NUTR, V106, P123, DOI 10.1017/S0007114510005829
   Bonifazi M, 2009, J ENDOCRINOL INVEST, V32, P816, DOI [10.1007/BF03345751, 10.3275/6428]
   Chen CW, 2016, J APPL PHYSIOL, V121, P870, DOI 10.1152/japplphysiol.00393.2016
   Chen C, 2017, FRONT NEUROENDOCRIN, V44, P83, DOI 10.1016/j.yfrne.2016.12.001
   Chen JW, 2010, J IMMUNOL METHODS, V357, P33, DOI 10.1016/j.jim.2010.03.006
   Choi KM, 2012, J CLIN ENDOCR METAB, V97, P3751, DOI 10.1210/jc.2012-1951
   Christiansen T, 2010, AM J PHYSIOL-ENDOC M, V298, pE824, DOI 10.1152/ajpendo.00574.2009
   Church TS, 2010, MED SCI SPORT EXER, V42, P708, DOI 10.1249/MSS.0b013e3181c03a43
   Criswell DS, 2004, IMMUNOL LETT, V95, P213, DOI 10.1016/j.imlet.2004.07.012
   Cyranowski JM, 2007, BRAIN BEHAV IMMUN, V21, P229, DOI 10.1016/j.bbi.2006.07.005
   Dhabhar FS, 2014, IMMUNOL RES, V58, P193, DOI 10.1007/s12026-014-8517-0
   Dhabhar FS, 2010, BRAIN BEHAV IMMUN, V24, P127, DOI 10.1016/j.bbi.2009.09.004
   Dhabhar FS, 1997, BRAIN BEHAV IMMUN, V11, P286, DOI 10.1006/brbi.1997.0508
   DIENSTBIER RA, 1989, PSYCHOL REV, V96, P84, DOI 10.1037/0033-295X.96.1.84
   Donges CE, 2010, MED SCI SPORT EXER, V42, P304, DOI 10.1249/MSS.0b013e3181b117ca
   Donnelly JE, 2003, ARCH INTERN MED, V163, P1343, DOI 10.1001/archinte.163.11.1343
   Duclos M, 1999, CLIN ENDOCRINOL, V51, P749, DOI 10.1046/j.1365-2265.1999.00878.x
   Ford ES, 2002, EPIDEMIOLOGY, V13, P561, DOI 10.1097/00001648-200209000-00012
   Frellstedt L, 2014, AM J RESP CELL MOL, V51, P135, DOI 10.1165/rcmb.2013-0341OC
   Gerber M, 2013, STRESS, V16, P593, DOI 10.3109/10253890.2013.823599
   Grasso G, 1997, LIFE SCI, V61, P301, DOI 10.1016/S0024-3205(97)00386-X
   Hamer M, 2012, CIRCULATION, V126, P928, DOI 10.1161/CIRCULATIONAHA.112.103879
   Itoh CE, 2004, BIOCHEM BIOPH RES CO, V322, P979, DOI 10.1016/j.bbrc.2004.08.050
   Jacobs AK, 2002, J AM COLL CARDIOL, V39, P1608, DOI 10.1016/S0735-1097(02)01835-1
   Johannsen NM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031319
   Keller C, 2005, J APPL PHYSIOL, V99, P2075, DOI 10.1152/japplphysiol.00590.2005
   King DE, 2003, MED SCI SPORT EXER, V35, P575, DOI 10.1249/01.MSS.0000058440.28108.CC
   Kizaki T, 2008, BIOCHEM BIOPH RES CO, V372, P152, DOI 10.1016/j.bbrc.2008.05.005
   Kohut ML, 2006, BRAIN BEHAV IMMUN, V20, P201, DOI 10.1016/j.bbi.2005.12.002
   Krause M, 2014, EUR J APPL PHYSIOL, V114, P251, DOI 10.1007/s00421-013-2769-6
   Lakka TA, 2005, EUR HEART J, V26, P2018, DOI 10.1093/eurheartj/ehi394
   Libardi CA, 2011, J SPORT SCI, V29, P1573, DOI 10.1080/02640414.2011.609896
   Marsland AL, 2017, BRAIN BEHAV IMMUN, V64, P208, DOI 10.1016/j.bbi.2017.01.011
   Martín-Cordero L, 2011, NEUROIMMUNOMODULAT, V18, P123, DOI 10.1159/000322053
   McKinley PS, 2009, PSYCHOPHYSIOLOGY, V46, P904, DOI 10.1111/j.1469-8986.2009.00811.x
   Miller GE, 2005, PSYCHOSOM MED, V67, P679, DOI 10.1097/01.psy.0000174172.82428.ce
   Miller GE, 2002, HEALTH PSYCHOL, V21, P531, DOI 10.1037//0278-6133.21.6.531
   Miller GE, 2010, PSYCHOL SCI, V21, P848, DOI 10.1177/0956797610370161
   Mulligan NW, 2003, CAN J EXP PSYCHOL, V57, P152, DOI 10.1037/h0087422
   Nikseresht M, 2014, J STRENGTH COND RES, V28, P3399, DOI 10.1519/JSC.0000000000000553
   Okita K, 2004, ARTERIOSCL THROM VAS, V24, P1868, DOI 10.1161/01.ATV.0000140199.14930.32
   Olesen J, 2015, J APPL PHYSIOL, V118, P818, DOI 10.1152/japplphysiol.00725.2014
   Olesen J, 2014, J PHYSIOL-LONDON, V592, P1873, DOI 10.1113/jphysiol.2013.270256
   PECHAR GS, 1974, J APPL PHYSIOL, V36, P753, DOI 10.1152/jappl.1974.36.6.753
   Peijie C, 2004, J SPORT MED PHYS FIT, V44, P322
   Peppler WT, 2016, AM J PHYSIOL-REG I, V310, pR934, DOI 10.1152/ajpregu.00497.2015
   Rauramaa R, 2004, ANN INTERN MED, V140, P1007, DOI 10.7326/0003-4819-140-12-200406150-00010
   Rawson ES, 2003, MED SCI SPORT EXER, V35, P1160, DOI 10.1249/01.MSS.0000074565.79230.AB
   Roberts CK, 2006, J APPL PHYSIOL, V100, P1657, DOI 10.1152/japplphysiol.01292.2005
   Rönn T, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003572
   Serhan CN, 2014, NATURE, V510, P92, DOI 10.1038/nature13479
   Serhan CN, 2005, NAT IMMUNOL, V6, P1191, DOI 10.1038/ni1276
   Shafer J.L., 1997, ANAL INCOMPLETE MULT
   Shirato K, 2017, MEDIAT INFLAMM, V2017, DOI 10.1155/2017/9290416
   Silva TS, 2008, HORM METAB RES, V40, P718, DOI 10.1055/s-2008-1078727
   Silverman MN, 2012, ANN NY ACAD SCI, V1261, P55, DOI 10.1111/j.1749-6632.2012.06633.x
   Skoluda N, 2012, PSYCHONEUROENDOCRINO, V37, P611, DOI 10.1016/j.psyneuen.2011.09.001
   Sloan RP, 2007, J APPL PHYSIOL, V103, P1007, DOI 10.1152/japplphysiol.00147.2007
   Silva TSE, 2010, HORM RES PAEDIAT, V74, P6, DOI 10.1159/000313586
   Stewart LK, 2005, BRAIN BEHAV IMMUN, V19, P389, DOI 10.1016/j.bbi.2005.04.003
   Suarez EC, 2004, PSYCHONEUROENDOCRINO, V29, P1119, DOI 10.1016/j.psyneuen.2004.01.002
   Suarez EC, 2002, BRAIN BEHAV IMMUN, V16, P675, DOI 10.1016/S0889-1591(02)00019-3
   Sugiura H, 2002, ACTA PHYSIOL SCAND, V174, P247, DOI 10.1046/j.1365-201x.2002.00930.x
   TANAKA H, 1994, SPORTS MED, V18, P330, DOI 10.2165/00007256-199418050-00005
   Thompson AM, 2008, CONTEMP CLIN TRIALS, V29, P418, DOI 10.1016/j.cct.2007.09.009
   Thompson D, 2010, J APPL PHYSIOL, V108, P769, DOI 10.1152/japplphysiol.00822.2009
   Timmerman KL, 2008, J LEUKOCYTE BIOL, V84, P1271, DOI 10.1189/jlb.0408244
   van den Biggelaar AHJ, 2007, EXP GERONTOL, V42, P693, DOI 10.1016/j.exger.2007.01.011
   Verdaet D, 2004, ATHEROSCLEROSIS, V176, P303, DOI 10.1016/j.atherosclerosis.2004.05.007
   Wagner G, 2015, J CEREBR BLOOD F MET, V35, P1570, DOI 10.1038/jcbfm.2015.125
   Wang CH, 2014, GERIATR NURS, V35, P212, DOI 10.1016/j.gerinurse.2014.02.001
   Wannamethee SG, 2002, CIRCULATION, V105, P1785, DOI 10.1161/01.CIR.0000016346.14762.71
   Woods JA, 2012, AGING DIS, V3, P130
NR 75
TC 22
Z9 23
U1 2
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD SEP 4
PY 2018
VL 7
IS 17
AR e010201
DI 10.1161/JAHA.118.010201
PG 20
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA HD8KL
UT WOS:000452804600026
PM 30371169
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Joseph, G
   Soler, A
   Hutcheson, R
   Hunter, I
   Bradford, C
   Hutcheson, B
   Gotlinger, KH
   Jiang, HL
   Falck, JR
   Proctor, S
   Schwartzman, ML
   Rocic, P
AF Joseph, Gregory
   Soler, Amanda
   Hutcheson, Rebecca
   Hunter, Ian
   Bradford, Chastity
   Hutcheson, Brenda
   Gotlinger, Katherine H.
   Jiang, Houli
   Falck, John R.
   Proctor, Spencer
   Schwartzman, Michal Laniado
   Rocic, Petra
TI Elevated 20-HETE impairs coronary collateral growth in metabolic
   syndrome via endothelial dysfunction
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE 20-HETE; miR-145; arteriogenesis; endothelial dysfunction; neutrophils
ID 20-HYDROXYEICOSATETRAENOIC ACID SYNTHESIS; ANGIOTENSIN-II; INFLAMMATORY
   CYTOKINES; RECEPTOR BLOCKADE; HUMAN NEUTROPHILS; ARACHIDONIC-ACID;
   OXIDATIVE STRESS; KAPPA-B; HYPERTENSION; ACTIVATION
AB Coronary collateral growth (CCG) is impaired in metabolic syndrome (MetS). microRNA-145 (miR-145-Adv) delivery to our rat model of MetS (JCR) completely restored and neutrophil depletion significantly improved CCG. We determined whether low endogenous levels of miR-145 in MetS allowed for elevated production of 20-hydroxyeicosatetraenoic acid (20-HETE), which, in turn, resulted in excessive neutrophil accumulation and endothelial dysfunction leading to impaired CCG. Rats underwent 0-9 days of repetitive ischemia (RI). RI-induced cardiac CYP4F (neutrophil-specific 20-HETE synthase) expression and 20-HETE levels were increased (4-fold) in JCR vs. normal rats. miR-145-Adv and 20-HETE antagonists abolished and neutrophil depletion (blocking antibodies) reduced (similar to 60%) RI-induced increases in CYP4F expression and 20-HETE production in JCR rats. Impaired CCG in JCR rats (collateral-dependent blood flow using microspheres) was completely restored by 20-HETE antagonists [collateral-dependent zone (CZ)/normal zone (NZ) flow ratio was 0.76 +/- 0.07 in JCR +/- 20-SOLA, 0.84 +/- 0.05 in JCR + 20-HEDGE vs. 0.11 +/- 0.02 in JCR vs. 0.84 +/- 0.03 in normal rats]. In JCR rats, elevated 20-HETE was associated with excessive expression of endothelial adhesion molecules and neutrophil infiltration, which were reversed by miR-145-Adv. Endothelium-dependent vasodilation of coronary arteries, endothelial nitric oxide synthase (eNOS) Ser1179 phosphorylation, eNOS-dependent NO center dot- production and endothelial cell survival were compromised in JCR rats. These parameters of endothelial dysfunction were completely reversed by 20-HETE antagonism or miR-145-Adv delivery, whereas neutrophil depletion resulted in partial reversal similar to 70%). We conclude that low miR-145 in MetS allows for increased 20-HETE, mainly from neutrophils, which compromises endothelial cell survival and function leading to impaired CCG. 20-HETE antagonists could provide viable therapy for restoration of CCG in MetS.
   NEW & NOTEWORTHY Elevated 20-hydroxyeicosatetraenoic acid (20-HETE) impairs coronary collateral growth (CCG) in metabolic syndrome by eliciting endothelial dysfunction and apoptosis via excessive neutrophil infiltration. 20-HETE antagonists completely restore coronary collateral growth in metabolic syndrome. mi-croRNA-145 (miR-145) is an upstream regulator of 20-HETE production in metabolic syndrome; low expression of miR-145 in metabolic syndrome promotes elevated production of 20-HETE.
C1 [Joseph, Gregory; Soler, Amanda; Hutcheson, Rebecca; Hunter, Ian; Hutcheson, Brenda; Gotlinger, Katherine H.; Jiang, Houli; Schwartzman, Michal Laniado; Rocic, Petra] New York Med Coll, Dept Pharmacol, BSB 502 Dana Rd, Valhalla, NY 10595 USA.
   [Bradford, Chastity] Tuskegee Univ, Dept Biol, Tuskegee, AL USA.
   [Falck, John R.] Univ Texas Southwestern Med Ctr, Dept Pharmacol, Dallas, TX USA.
   [Proctor, Spencer] Univ Alberta, Alberta Inst Human Nutr, Metabol & Cardiovasc Dis Lab, Edmonton, AB, Canada.
C3 New York Medical College; Tuskegee University; University of Texas
   System; University of Texas Southwestern Medical Center Dallas;
   University of Alberta
RP Rocic, P (corresponding author), New York Med Coll, Dept Pharmacol, BSB 502 Dana Rd, Valhalla, NY 10595 USA.
EM petra_rocic@nymc.edu
RI Proctor, Spencer/F-2774-2012; Falck, John/B-3030-2011
OI Bradford, Chastity/0000-0001-7460-6134; Proctor,
   Spencer/0000-0002-7597-5262; Rocic, Petra/0000-0002-5781-3075
FU National Heart, Lung, and Blood Institute [R01-HL-093052, P01-HL-034300]
FX This work was supported by National Heart, Lung, and Blood Institute
   Grants R01-HL-093052 (to P. Rocic) and P01-HL-034300 (to M. L.
   Schwartzman).
CR Akbulut T, 2009, AM J PHYSIOL-RENAL, V297, pF662, DOI 10.1152/ajprenal.00146.2009
   AlonsoGalicia M, 1997, HYPERTENSION, V29, P320, DOI 10.1161/01.HYP.29.1.320
   Aoki M, 2001, HYPERTENSION, V38, P48, DOI 10.1161/01.HYP.38.1.48
   Archer SL, 2003, CIRCULATION, V107, P769, DOI 10.1161/01.CIR.0000047278.28407.C2
   Bang L, 1999, CARDIOVASC RES, V43, P772, DOI 10.1016/S0008-6363(99)00116-9
   Boerth NJ, 1997, J VASC RES, V34, P245, DOI 10.1159/000159231
   Borin TF, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0116247
   Buschmann I, 2003, MICROCIRCULATION, V10, P371, DOI 10.1038/sj.mn.7800199
   Buschmann I, 1999, NEWS PHYSIOL SCI, V14, P121
   Carmeliet P, 2000, NAT MED, V6, P389, DOI 10.1038/74651
   Carrao ACR, 2009, ARTERIOSCL THROM VAS, V29, P1817, DOI 10.1161/ATVBAHA.109.186445
   Chen L, 2016, VASC PHARMACOL, V83, P57, DOI 10.1016/j.vph.2016.04.002
   Chen L, 2014, J PHARMACOL EXP THER, V348, P442, DOI 10.1124/jpet.113.210120
   Chen L, 2012, PROSTAG OTH LIPID M, V98, P63, DOI 10.1016/j.prostaglandins.2011.12.005
   Chen P, 2005, AM J PATHOL, V166, P615, DOI 10.1016/S0002-9440(10)62282-1
   Cheng J, 2008, AM J PHYSIOL-HEART C, V294, pH1018, DOI 10.1152/ajpheart.01172.2007
   Cheng J, 2010, J PHARMACOL EXP THER, V332, P57, DOI 10.1124/jpet.109.159863
   de Muinck ED, 2009, ANTIOXID REDOX SIGN, V11, P2025, DOI [10.1089/ars.2009.2495, 10.1089/ARS.2009.2495]
   Degen A, 2014, CURR CARDIOL REV, V10, P65, DOI 10.2174/1573403X113099990027
   Dhanasekaran A, 2009, AM J PHYSIOL-HEART C, V296, pH777, DOI 10.1152/ajpheart.01087.2008
   Ding H, 2005, VASC HEALTH RISK MAN, V1, P55, DOI 10.2147/vhrm.1.1.55.58939
   Ding Y, 2013, AM J PHYSIOL-RENAL, V305, pF753, DOI 10.1152/ajprenal.00292.2013
   Dodd T, 2013, ARTERIOSCL THROM VAS, V33, P1339, DOI 10.1161/ATVBAHA.113.301533
   Dodd T, 2011, J MOL CELL CARDIOL, V51, P1015, DOI 10.1016/j.yjmcc.2011.08.012
   Epstein SE, 2001, CARDIOVASC RES, V49, P532, DOI 10.1016/S0008-6363(00)00217-0
   ESCALANTE B, 1994, AM J PHYSIOL, V266, pC1775, DOI 10.1152/ajpcell.1994.266.6.C1775
   Fava C, 2012, PROSTAG OTH LIPID M, V98, P31, DOI 10.1016/j.prostaglandins.2012.03.001
   Gangadhariah MH, 2015, J AM SOC NEPHROL, V26, P597, DOI 10.1681/ASN.2013090980
   Garcia V, 2015, AM J PHYSIOL-REG I, V309, pR71, DOI 10.1152/ajpregu.00039.2015
   Gauthier KM, 2005, HYPERTENSION, V45, P666, DOI 10.1161/01.HYP.0000153462.06604.5d
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Guo AM, 2007, J PHARMACOL EXP THER, V321, P18, DOI 10.1124/jpet.106.115360
   Guo AM, 2011, J PHARMACOL EXP THER, V338, P421, DOI 10.1124/jpet.111.179036
   Guo AM, 2009, AM J PHYSIOL-HEART C, V297, pH602, DOI 10.1152/ajpheart.00874.2008
   Guzik TJ, 2002, HYPERTENSION, V39, P1088, DOI 10.1161/01.HYP.0000018041.48432.B5
   Hadi HAR, 2005, VASC HEALTH RISK MAN, V1, P183
   Harder DR, 1997, J VASC RES, V34, P237, DOI 10.1159/000159228
   Hoopes SL, 2015, PROSTAG OTH LIPID M, V120, P9, DOI 10.1016/j.prostaglandins.2015.03.002
   Hutcheson R, 2015, AM J PHYSIOL-HEART C, V308, pH1323, DOI 10.1152/ajpheart.00654.2014
   Hutcheson R, 2014, FASEB J, V28, P4088, DOI 10.1096/fj.14-251223
   Hutcheson R, 2013, ARTERIOSCL THROM VAS, V33, P727, DOI 10.1161/ATVBAHA.112.301116
   Hutcheson R, 2012, EXP DIABETES RES, DOI 10.1155/2012/271028
   Iantorno M, 2014, J BIOL REG HOMEOS AG, V28, P169
   Inoue K, 2009, AM J PHYSIOL-RENAL, V297, pF875, DOI 10.1152/ajprenal.00364.2009
   Ishizuka T, 2008, J PHARMACOL EXP THER, V324, P103, DOI 10.1124/jpet.107.130336
   Jadhav R, 2011, AM J PHYSIOL-HEART C, V300, pH1938, DOI 10.1152/ajpheart.00282.2010
   KAUSER K, 1991, CIRC RES, V68, P1154, DOI 10.1161/01.RES.68.4.1154
   Kobayashi N, 2005, ARTERIOSCL THROM VAS, V25, P2114, DOI 10.1161/01.ATV.0000178993.13222.f2
   Kojda G, 1999, CARDIOVASC RES, V43, P562, DOI 10.1016/S0008-6363(99)00169-8
   Laffer CL, 2004, HYPERTENSION, V43, P388, DOI 10.1161/01.HYP.0000112224.87290.3a
   Lai GR, 2012, MOL ENDOCRINOL, V26, P1907, DOI 10.1210/me.2012-1139
   Liang CJ, 2008, J LIPID RES, V49, P66, DOI 10.1194/jlr.M700155-JLR200
   Liu ZJ, 2003, MOL CELL BIOL, V23, P14, DOI 10.1128/MCB.23.1.14-25.2003
   Matsunaga T, 2000, CIRCULATION, V102, P3098
   MCNAMEE CJ, 1994, CIRC RES, V74, P1126, DOI 10.1161/01.RES.74.6.1126
   Moraes F, 2013, CIRC RES, V113, P1076, DOI 10.1161/CIRCRESAHA.113.301340
   Mouquet F, 2009, EUR HEART J, V30, P840, DOI 10.1093/eurheartj/ehn569
   NATARAJAN R, 1993, P NATL ACAD SCI USA, V90, P4947, DOI 10.1073/pnas.90.11.4947
   Reed R, 2008, ARTERIOSCL THROM VAS, V28, P61, DOI 10.1161/ATVBAHA.107.154294
   Reed R, 2009, AM J PHYSIOL-HEART C, V296, pH1811, DOI 10.1152/ajpheart.00920.2008
   Regner KR, 2009, KIDNEY INT, V75, P511, DOI 10.1038/ki.2008.600
   Rocic P, 2007, AM J PHYSIOL-HEART C, V292, pH2729, DOI 10.1152/ajpheart.01330.2006
   Rocic P, 2012, VASC PHARMACOL, V57, P179, DOI 10.1016/j.vph.2012.02.001
   Sánchez-Mendoza A, 2000, BIOCHEM BIOPH RES CO, V272, P423, DOI 10.1006/bbrc.2000.2807
   Santhanam AVR, 2012, J NEUROCHEM, V122, P1211, DOI 10.1111/j.1471-4159.2012.07872.x
   Sasmaz H, 2009, ANGIOLOGY, V60, P164, DOI 10.1177/0003319708316007
   Savoia C, 2011, INT J HYPERTENS, V2011, DOI 10.4061/2011/281240
   Scatena M, 2007, ARTERIOSCL THROM VAS, V27, P2302, DOI 10.1161/ATVBAHA.107.144824
   Schaper W, 2003, ARTERIOSCL THROM VAS, V23, P1143, DOI 10.1161/01.ATV.0000069625.11230.96
   Schaper W, 2009, BASIC RES CARDIOL, V104, P5, DOI 10.1007/s00395-008-0760-x
   Singh H, 2007, HYPERTENSION, V50, P123, DOI 10.1161/HYPERTENSIONAHA.107.089599
   Toyota E, 2005, CIRCULATION, V112, P2108, DOI 10.1161/CIRCULATIONAHA.104.526954
   Tsai IJ, 2011, AM J PHYSIOL-HEART C, V300, pH1194, DOI 10.1152/ajpheart.00733.2010
   TSAO PS, 1992, AM HEART J, V123, P1464, DOI 10.1016/0002-8703(92)90796-X
   Tsihlis ND, 2011, CELL BIOCHEM BIOPHYS, V60, P89, DOI 10.1007/s12013-011-9179-3
   Uno K, 2004, J PHARMACOL EXP THER, V309, P995, DOI 10.1124/jpet.103.061283
   van den Oever IAM, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/792393
   van Royen N, 2001, CARDIOVASC RES, V49, P543, DOI 10.1016/S0008-6363(00)00206-6
   Wang JH, 1997, SHOCK, V8, P357, DOI 10.1097/00024382-199711000-00007
   Wang JS, 2006, CIRC RES, V98, P962, DOI 10.1161/01.RES.0000217283.98806.a6
   Ward NC, 2004, CIRCULATION, V110, P438, DOI 10.1161/01.CIR.0000136808.72912.D9
   Woodfin A, 2009, BLOOD, V113, P6246, DOI 10.1182/blood-2008-11-188375
   Wu CC, 2014, CARDIOL REV, V22, P1, DOI 10.1097/CRD.0b013e3182961659
   Yang HT, 2001, AM J PHYSIOL-HEART C, V280, pH1097, DOI 10.1152/ajpheart.2001.280.3.H1097
   Yang JY, 2009, AM J PHYSIOL-HEART C, V297, pH1208, DOI 10.1152/ajpheart.00396.2009
   Yun J, 2009, ANTIOXID REDOX SIGN, V11, P1961, DOI [10.1089/ars.2009.2476, 10.1089/ARS.2009.2476]
   ZOU AP, 1994, AM J PHYSIOL, V266, pF934, DOI 10.1152/ajprenal.1994.266.6.F934
NR 87
TC 32
Z9 39
U1 2
U2 10
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD MAR
PY 2017
VL 312
IS 3
BP H528
EP H540
DI 10.1152/ajpheart.00561.2016
PG 13
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA EQ1DC
UT WOS:000397808500018
PM 28011587
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Williams, G
AF Williams, Graeme
TI Aromatase up-regulation, insulin and raised intracellular oestrogens in
   men, induce adiposity, metabolic syndrome and prostate disease, via
   aberrant ER-α and GPER signalling
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article
DE Aromatase; ER-alpha; GPER; Obesity; Metabolic syndrome; Prostate disease
ID BREAST-CANCER CELLS; SERUM LEPTIN LEVELS; ERECTILE DYSFUNCTION;
   SEX-HORMONES; RECEPTOR-ALPHA; NONGENOMIC ACTIONS; RISK-FACTORS;
   ENDOCRINE DISRUPTORS; MESSENGER-RNA; BODY-FAT
AB For some years now, reduced testosterone levels have been related to obesity, insulin resistance, type 2 diabetes, heart disease, benign prostatic hypertrophy and even prostate cancer - often considered guilty more by association, than actual cause - with little attention paid to the important role of increased intracellular oestrogen, in the pathogenesis of these chronic diseases.
   In the final stage of the steroidogenic cascade, testosterone is metabolised to oestradiol by P450 aromatase, in the cytoplasm of adipocytes, breast cells, endothelial cells and prostate cells, to increase intracellular oestradiol concentration at the expense of testosterone.
   It follows therefore, that any compound that up-regulates aromatase, or any molecule that mimics oestrogen, will not only increase the activation of the mainly proliferative, classic ER-alpha, oestrogen receptors to induce adipogenesis and growth disorders in oestrogen-sensitive tissues, but also activate the recently identified transmembrane G protein-coupled oestrogen receptors (GPER), and deleteriously alter important intracellular signalling sequences, that promote mitogenic growth and endothelial damage.
   This paper simplifies how stress, xeno-oestrogens, poor dietary choices and reactive toxins up-regulate aromatase to increase intracellular oestradiol production; how oestradiol in combination with leptin and insulin cause insulin resistance and leptin resistance through aberrant serine phosphorylation; how the increased oestradiol, insulin and leptin stimulate rapid, non-genomic G protein-coupled phosphorylation cascades, to increase fat deposition and create the vasoconstrictive, dyslipidemic features of metabolic syndrome; how aberrant GPER signalling induces benign prostatic hypertrophy; and how increased intracellular oestradiol stimulates mitogenic change and tumour-cell activators, to cause prostate cancer.
   In essence, the up-regulation of aromatase produces increased intracellular oestradiol, increases ER-alpha activation and increases GPER activation, in combination with insulin, to cause aberrant downstream transduction signaling, and thus induce metabolic syndrome and mitogenic prostate growth.
   To understand this fact, that raised intracellular oestradiol levels in men, induce and promote obesity, gynecomastia, metabolic syndrome, type two diabetes, benign prostatic hypertrophy and prostate cancer, rather than low testosterone, represents a shift in medical thinking, a new awareness, that will reduce the rising incidence of obesity, metabolic syndrome and prostate disease, and significantly improve the health of men worldwide. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
C1 Metab Endocrinol & Clin Res, Noosa Heads, Qld 4567, Australia.
RP Williams, G (corresponding author), Metab Endocrinol & Clin Res, POB 1574, Noosa Heads, Qld 4567, Australia.
EM graemewilliams8@bigpond.com
CR Al-Hunayan A, 2007, BJU INT, V99, P130, DOI 10.1111/j.1464-410X.2006.06550.x
   [Anonymous], 2006, National Chronic Disease Strategy
   [Anonymous], 2010, LANGE GANONGS REV ME
   [Anonymous], IDF DIAB ATL
   Bal K, 2007, UROLOGY, V69, P356, DOI 10.1016/j.urology.2006.09.057
   Banks AS, 2000, J BIOL CHEM, V275, P14563, DOI 10.1074/jbc.275.19.14563
   Bardin A, 2004, ENDOCR-RELAT CANCER, V11, P537, DOI 10.1677/erc.1.00800
   Bastard JP, 2006, EUR CYTOKINE NETW, V17, P4
   Biddinger SB, 2006, ANNU REV PHYSIOL, V68, P123, DOI 10.1146/annurev.physiol.68.040104.124723
   Borugian MJ, 2003, AM J EPIDEMIOL, V158, P963, DOI 10.1093/aje/kwg236
   Carr B., 2005, HARRISONS PRINCIPLES, P2201
   Carruba G, 2006, ANN NY ACAD SCI, V1089, P201, DOI 10.1196/annals.1386.027
   Castracane VD, 1998, FERTIL STERIL, V70, P472, DOI 10.1016/S0015-0282(98)00187-3
   Catalano S, 2004, J BIOL CHEM, V279, P19908, DOI 10.1074/jbc.M313191200
   Catalano S, 2003, J BIOL CHEM, V278, P28668, DOI 10.1074/jbc.M301695200
   Catalano S, 2009, J CELL PHYSIOL, V218, P490, DOI 10.1002/jcp.21622
   Cirillo D, 2008, J CELL BIOCHEM, V105, P956, DOI 10.1002/jcb.21911
   Corona G, 2009, INT J ANDROL, V32, P720, DOI 10.1111/j.1365-2605.2009.00952.x
   Daghestani MH, 2007, SAUDI MED J, V28, P1191
   Dallman MF, 2007, CURR ALZHEIMER RES, V4, P199, DOI 10.2174/156720507780362236
   Dees C, 1997, MOL CARCINOGEN, V18, P107, DOI 10.1002/(SICI)1098-2744(199702)18:2<107::AID-MC6>3.0.CO;2-D
   Demir T, 2006, INT J UROL, V13, P385, DOI 10.1111/j.1442-2042.2006.01310.x
   Dhindsa S, 2004, J CLIN ENDOCR METAB, V89, P5462, DOI 10.1210/jc.2004-0804
   Dieudonné MN, 2006, J STEROID BIOCHEM, V99, P189, DOI 10.1016/j.jsbmb.2006.01.007
   Ding EL, 2006, JAMA-J AM MED ASSOC, V295, P1288, DOI 10.1001/jama.295.11.1288
   Dundar B, 2005, J PEDIATR ENDOCR MET, V18, P929
   Dyck DJ, 2006, ACTA PHYSIOL, V186, P5, DOI 10.1111/j.1748-1716.2005.01502.x
   Eaton CB, 2007, INT J IMPOT RES, V19, P218, DOI 10.1038/sj.ijir.3901519
   Ellem SJ, 2007, NAT REV CANCER, V7, P621, DOI 10.1038/nrc2174
   Esposito K, 2005, DIABETES CARE, V28, P1201, DOI 10.2337/diacare.28.5.1201
   Faulconnier Y, 2003, REPROD NUTR DEV, V43, P237, DOI 10.1051/rnd:2003018
   Filardo E, 2007, ENDOCRINOLOGY, V148, P3236, DOI 10.1210/en.2006-1605
   Filardo EJ, 2000, MOL ENDOCRINOL, V14, P1649, DOI 10.1210/me.14.10.1649
   Foster MT, 2009, ENDOCRINOLOGY, V150, P2325, DOI 10.1210/en.2008-1426
   Fujita N, 2003, EXP BIOL MED, V228, P1156, DOI 10.1177/153537020322801009
   Gann PH, 1996, J NATL CANCER I, V88, P1118, DOI 10.1093/jnci/88.16.1118
   García-Arencibia M, 2005, LEUKEMIA RES, V29, P79, DOI 10.1016/j.leukres.2004.05.012
   Geisler J, 2007, J STEROID BIOCHEM, V104, P27, DOI 10.1016/j.jsbmb.2006.09.040
   Gong ZH, 2006, CANCER EPIDEM BIOMAR, V15, P1977, DOI 10.1158/1055-9965.EPI-06-0477
   González C, 2002, STEROIDS, V67, P993, DOI 10.1016/S0039-128X(02)00073-9
   Grosse Y, 2009, LANCET ONCOL, V10, P13, DOI 10.1016/S1470-2045(08)70286-9
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Gustafsson O, 1996, BRIT J UROL, V77, P433, DOI 10.1046/j.1464-410X.1996.89120.x
   HAFFNER SM, 1994, METABOLISM, V43, P599, DOI 10.1016/0026-0495(94)90202-X
   HAFFNER SM, 1994, DIABETES, V43, P212, DOI 10.2337/diabetes.43.2.212
   Hak AE, 2002, J CLIN ENDOCR METAB, V87, P3632, DOI 10.1210/jc.87.8.3632
   Hammarsten J, 2005, EUR J CANCER, V41, P2887, DOI 10.1016/j.ejca.2005.09.003
   Hammarsten J, 2004, BLOOD PRESSURE, V13, P47, DOI 10.1080/08037050310025735
   Hammarsten J, 1998, PROSTATE CANCER P D, V1, P157, DOI 10.1038/sj.pcan.4500221
   Hammarsten J, 2009, PROSTATE CANCER P D, V12, P160, DOI 10.1038/pcan.2008.50
   Heidler S, 2007, J UROLOGY, V177, P651, DOI 10.1016/j.juro.2006.09.043
   Hennige AM, 2006, FASEB J, V20, P1206, DOI 10.1096/fj.05-4635fje
   HILF R, 1985, ENDOCRINOLOGY, V116, P154, DOI 10.1210/endo-116-1-154
   Ho SC, 1999, INT J OBESITY, V23, P246, DOI 10.1038/sj.ijo.0800801
   Hsing AW, 2001, JNCI-J NATL CANCER I, V93, P783, DOI 10.1093/jnci/93.10.783
   Iguchi T, 2008, INT J ANDROL, V31, P263, DOI 10.1111/j.1365-2605.2008.00863.x
   Irigaray P, 2007, BIOMED PHARMACOTHER, V61, P665, DOI 10.1016/j.biopha.2007.10.008
   Ishida-Takahashi R, 2006, MOL CELL BIOL, V26, P4063, DOI 10.1128/MCB.01589-05
   Kaaks Rudolf, 2004, Novartis Found Symp, V262, P247
   Kellerer M, 2001, DIABETOLOGIA, V44, P1125, DOI 10.1007/s001250100614
   Key TJ, 2003, J NATL CANCER I, V95, P1218, DOI 10.1093/jnci/djg022
   Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213
   Kinoshita Y, 2003, CANCER RES, V63, P3546
   Kojima H, 2010, J HEALTH SCI, V56, P374, DOI 10.1248/jhs.56.374
   Laaksonen DE, 2003, EUR J ENDOCRINOL, V149, P601, DOI 10.1530/eje.0.1490601
   Lapauw B, 2009, EUR J ENDOCRINOL, V160, P397, DOI 10.1530/EJE-08-0881
   Laukkanen JA, 2004, CANCER EPIDEM BIOMAR, V13, P1646
   Laville N, 2006, TOXICOLOGY, V228, P98, DOI 10.1016/j.tox.2006.08.021
   Lieb W, 2009, DIABETES CARE, V32, P612, DOI 10.2337/dc08-1596
   Lindsay RS, 2004, CLIN ENDOCRINOL, V61, P353, DOI 10.1111/j.1365-2265.2004.02104.x
   Livingstone C, 2002, CLIN SCI, V102, P151, DOI 10.1042/cs1020151
   Manderson JG, 2003, AM J OBSTET GYNECOL, V188, P1326, DOI 10.1067/mob.2003.276
   Mistry T, 2007, EUR UROL, V52, P46, DOI 10.1016/j.eururo.2007.03.054
   Morley J.E., 2000, MAYO CLIN P, V75, P83
   Murakami H, 2001, J STEROID BIOCHEM, V79, P67, DOI 10.1016/S0960-0760(01)00128-5
   Nadal A, 2000, P NATL ACAD SCI USA, V97, P11603, DOI 10.1073/pnas.97.21.11603
   Newbold RR, 2008, INT J ANDROL, V31, P201, DOI 10.1111/j.1365-2605.2007.00858.x
   Nilsson R, 2000, TOXICOL PATHOL, V28, P420, DOI 10.1177/019262330002800311
   Osuna JA, 2006, ARCH ANDROLOGY, V52, P355, DOI 10.1080/01485010600692017
   Ozden C, 2007, EUR UROL, V51, P199, DOI 10.1016/j.eururo.2006.05.040
   Pausova Z, 2006, CURR OPIN NEPHROL HY, V15, P173, DOI 10.1097/01.mnh.0000214775.42103.a5
   Petersen KR, 2002, DAN MED BULL, V49, P43
   Phillips GB, 2003, METABOLISM, V52, P784, DOI 10.1016/S0026-0495(03)00072-6
   Prins GS, 2008, ENDOCR-RELAT CANCER, V15, P649, DOI 10.1677/ERC-08-0043
   Prins GS, 2008, STEROIDS, V73, P233, DOI 10.1016/j.steroids.2007.10.013
   Prossnitz ER, 2009, PROSTAG OTH LIPID M, V89, P89, DOI 10.1016/j.prostaglandins.2009.05.001
   Rhoden EL, 2004, NEW ENGL J MED, V350, P482, DOI 10.1056/NEJMra022251
   Risbridger GP, 2003, ENDOCR-RELAT CANCER, V10, P187, DOI 10.1677/erc.0.0100187
   Samad F., 2007, ADIPOSE ESTROGEN INC
   Santner SJ, 1997, J CLIN ENDOCR METAB, V82, P200, DOI 10.1210/jc.82.1.200
   Saxena NK, 2007, J BIOL CHEM, V282, P13316, DOI 10.1074/jbc.M609798200
   Saxena NK, 2007, CANCER RES, V67, P2497, DOI 10.1158/0008-5472.CAN-06-3075
   Schatzl G, 2001, PROSTATE, V47, P52
   Schlumpf M, 2004, TOXICOLOGY, V205, P113, DOI 10.1016/j.tox.2004.06.043
   Shin JH, 2007, STEROIDS, V72, P592, DOI 10.1016/j.steroids.2007.03.013
   Stattin P, 2004, INT J CANCER, V108, P418, DOI 10.1002/ijc.11572
   Suganami T, 2010, J LEUKOCYTE BIOL, V88, P33, DOI 10.1189/jlb.0210072
   Sulkowska M, 2006, PATHOL ONCOL RES, V12, P69, DOI 10.1007/BF02893446
   Tanaka M, 2001, HORM RES, V56, P98, DOI 10.1159/000048099
   Thomas T, 2000, METABOLISM, V49, P1278, DOI 10.1053/meta.2000.9519
   Thornton MJ, 2006, J INVEST DERMATOL, V126, P2010, DOI 10.1038/sj.jid.5700344
   Uddin S, 2010, ENDOCR-RELAT CANCER, V17, P191, DOI 10.1677/ERC-09-0153
   Vecchione C, 2002, DIABETES, V51, P168, DOI 10.2337/diabetes.51.1.168
   Vona-Davis L, 2007, OBES REV, V8, P395, DOI 10.1111/j.1467-789X.2007.00396.x
   Watson CS, 2007, MOL CELL ENDOCRINOL, V274, P1, DOI 10.1016/j.mce.2007.05.011
   Watson CS, 2008, FASEB J, V22, P3328, DOI 10.1096/fj.08-107672
   Watson CS, 2007, STEROIDS, V72, P124, DOI 10.1016/j.steroids.2006.11.002
   Williams GP, 2010, EUR J CANCER PREV, V19, P256, DOI 10.1097/CEJ.0b013e328338f7d2
   World Health Organisation Global Infobase, 2004, WHO GLOB INF 2004 20
NR 109
TC 86
Z9 91
U1 0
U2 19
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD APR 4
PY 2012
VL 351
IS 2
BP 269
EP 278
DI 10.1016/j.mce.2011.12.017
PG 10
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 913VW
UT WOS:000301906500014
PM 22233684
DA 2025-06-11
ER

PT J
AU Abe, K
   Kuo, L
   Zukowska, Z
AF Abe, Ken
   Kuo, Lydia
   Zukowska, Zofia
TI Neuropeptide Y is a mediator of chronic vascular and metabolic
   maladaptations to stress and hypernutrition
SO EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Article; Proceedings Paper
CT Annual FASEB Experimental Biology Meeting
CY APR 21, 2009
CL San Diego, CA
DE atherosclerosis; cardiovascular disease; metabolic syndrome;
   neuropeptide Y; obesity; stress
ID SMOOTH-MUSCLE-CELLS; RAT CAROTID-ARTERY; ADIPOSE-TISSUE;
   SYMPATHETIC-NERVES; NERVOUS-SYSTEM; MESSENGER-RNA; IMMUNE-SYSTEM;
   BONE-MARROW; COLD STRESS; NPY
AB Neuropeptide Y (NPY) is a central neuromodulator and peripheral sympathetic neurotransmitter that also has important regulatory roles in cardiovascular, neuroendocrine, immune and metabolic functions during stress. Focusing on the peripheral actions of the peptide in rodent models, we summarize recent studies from our laboratory demonstrating that stress-induced release of NPY mediates accelerated atherosclerosis/restenosis, obesity and metabolic-like syndrome, particularly when combined with a high fat, high sugar diet. In this review, we propose mechanisms of NPY's actions, its receptors and cellular substrates that increase the risk for cardiovascular and metabolic diseases when chronic stress is associated with pre-existing vascular injury and/or states of hypernutrition.
C1 [Abe, Ken; Kuo, Lydia; Zukowska, Zofia] Georgetown Univ, Med Ctr, Dept Physiol & Biophys, Washington, DC 20057 USA.
C3 Georgetown University
RP Zukowska, Z (corresponding author), Georgetown Univ, Med Ctr, Dept Physiol & Biophys, 3900 Reservoir Rd NW, Washington, DC 20057 USA.
EM zzukow01@georgetown.edu
FU NHLBI NIH HHS [5R01HL067357-09] Funding Source: Medline
CR ALLEN JM, 1986, NEUROSCIENCE, V19, P1251, DOI 10.1016/0306-4522(86)90139-9
   Bedoui S, 2003, J NEUROIMMUNOL, V134, P1, DOI 10.1016/S0165-5728(02)00424-1
   Bedoui S, 2001, J NEUROIMMUNOL, V117, P125, DOI 10.1016/S0165-5728(01)00328-9
   Bedoui S, 2007, PEPTIDES, V28, P373, DOI 10.1016/j.peptides.2006.07.029
   CASTAGNE V, 1987, REGUL PEPTIDES, V19, P55, DOI 10.1016/0167-0115(87)90074-7
   Combettes M, 2007, THERAPIE, V62, P293, DOI 10.2515/therapie:2007054
   Dark J, 2008, AM J PHYSIOL-REG I, V294, pR236, DOI 10.1152/ajpregu.00587.2007
   Ekstrand AJ, 2003, P NATL ACAD SCI USA, V100, P6033, DOI 10.1073/pnas.1135965100
   ERICSSON A, 1991, EXP CELL RES, V192, P604, DOI 10.1016/0014-4827(91)90082-6
   ERICSSON A, 1987, P NATL ACAD SCI USA, V84, P5585, DOI 10.1073/pnas.84.16.5585
   ERICSSON A, 1987, IMMUNOL REV, V100, P261, DOI 10.1111/j.1600-065X.1987.tb00535.x
   ERLINGE D, 1994, REGUL PEPTIDES, V50, P259, DOI 10.1016/0167-0115(94)90006-X
   FALLGREN B, 1993, J AUTONOM NERV SYST, V44, P151, DOI 10.1016/0165-1838(93)90027-R
   Gluck EF, 2006, AM J PHYSIOL-REG I, V291, pR1303, DOI 10.1152/ajpregu.00232.2006
   Grant DS, 2000, ADV EXP MED BIOL, V476, P139
   Han SP, 1998, AM J PHYSIOL-HEART C, V274, pH290, DOI 10.1152/ajpheart.1998.274.1.H290
   Han SP, 1998, PEPTIDES, V19, P351, DOI 10.1016/S0196-9781(97)00297-0
   HEMSEN A, 1991, AGENTS ACTIONS, V34, P429, DOI 10.1007/BF01988740
   Kallio J, 2001, J CLIN ENDOCR METAB, V86, P5348, DOI 10.1210/jc.86.11.5348
   Karvonen MK, 2001, ATHEROSCLEROSIS, V159, P145, DOI 10.1016/S0021-9150(01)00468-3
   Kos K, 2007, AM J PHYSIOL-ENDOC M, V293, pE1335, DOI 10.1152/ajpendo.00333.2007
   Kuo LE, 2007, NAT MED, V13, P803, DOI 10.1038/nm1611
   Langin D, 2006, PHARMACOL RES, V53, P482, DOI 10.1016/j.phrs.2006.03.009
   Lavebratt C, 2006, INT J OBESITY, V30, P453, DOI 10.1038/sj.ijo.0803188
   Lee EW, 2003, J CLIN INVEST, V111, P1853, DOI 10.1172/JCI200316929
   Lee EW, 2003, PEPTIDES, V24, P99, DOI 10.1016/S0196-9781(02)00281-4
   Li LJ, 2005, ARTERIOSCL THROM VAS, V25, P2075, DOI 10.1161/01.ATV.0000179601.19888.19
   Li LJ, 2003, ARTERIOSCL THROM VAS, V23, P1204, DOI 10.1161/01.ATV.0000071349.30914.25
   MORRIS M, 1987, J CARDIOVASC PHARM, V9, P541, DOI 10.1097/00005344-198705000-00006
   Movafagh S, 2006, FASEB J, V20, P1924, DOI 10.1096/fj.05-4770fje
   MYERS AK, 1993, REGUL PEPTIDES, V47, P239, DOI 10.1016/0167-0115(93)90391-K
   Nie M, 1998, REGUL PEPTIDES, V75-6, P207, DOI 10.1016/S0167-0115(98)00070-6
   Pons J, 2003, CAN J PHYSIOL PHARM, V81, P177, DOI 10.1139/Y02-166
   Pons Jennifer, 2004, Curr Opin Investig Drugs, V5, P957
   Ritchie SA, 2007, NUTR METAB CARDIOVAS, V17, P319, DOI 10.1016/j.numecd.2006.07.005
   Robidoux J, 2004, ANNU REV PHARMACOL, V44, P297, DOI 10.1146/annurev.pharmtox.44.101802.121659
   Ruohonen S, 2009, PEPTIDES, V30, P715, DOI 10.1016/j.peptides.2008.12.009
   SCHWARZ H, 1994, J NEUROIMMUNOL, V51, P53, DOI 10.1016/0165-5728(94)90128-7
   Shah SH, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000318
   Straub RH, 2000, J LEUKOCYTE BIOL, V67, P553, DOI 10.1002/jlb.67.4.553
   Tabarowski Z, 1996, ACTA HISTOCHEM, V98, P453, DOI 10.1016/S0065-1281(96)80013-4
   TATEMOTO K, 1982, P NATL ACAD SCI-BIOL, V79, P5485, DOI 10.1073/pnas.79.18.5485
   Torres SJ, 2007, NUTRITION, V23, P887, DOI 10.1016/j.nut.2007.08.008
   Turtzo LC, 2002, HORM METAB RES, V34, P607, DOI 10.1055/s-2002-38245
   Wheway J, 2007, PEPTIDES, V28, P453, DOI 10.1016/j.peptides.2006.09.030
   Yang KP, 2008, FASEB J, V22, P2452, DOI 10.1096/fj.07-100735
   Zukowska-Grojec Z, 1998, CIRC RES, V83, P187, DOI 10.1161/01.RES.83.2.187
   ZUKOWSKAGROJEC Z, 1988, LIFE SCI, V42, P1615, DOI 10.1016/0024-3205(88)90440-7
   ZUKOWSKAGROJEC Z, 1988, SYNAPSE, V2, P293, DOI 10.1002/syn.890020319
   ZUKOWSKAGROJEC Z, 1993, PEPTIDES, V14, P263, DOI 10.1016/0196-9781(93)90040-N
   ZukowskaGrojec Z, 1995, ANN NY ACAD SCI, V771, P219, DOI 10.1111/j.1749-6632.1995.tb44683.x
NR 51
TC 27
Z9 31
U1 0
U2 3
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1535-3702
EI 1535-3699
J9 EXP BIOL MED
JI Exp. Biol. Med.
PD OCT
PY 2010
VL 235
IS 10
BP 1179
EP 1184
DI 10.1258/ebm.2010.009136
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Research & Experimental Medicine
GA 670VN
UT WOS:000283455500006
PM 20881322
DA 2025-06-11
ER

PT J
AU Pignatelli, P
   Menichelli, D
   Pastori, D
   Violi, F
AF Pignatelli, Pasquale
   Menichelli, Danilo
   Pastori, Daniele
   Violi, Francesco
TI Oxidative stress and cardiovascular disease: new insights
SO KARDIOLOGIA POLSKA
LA English
DT Review
DE oxidative stress; cardiovascular diseases; NADPH oxidase
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-ARTERY-DISEASE;
   EXTRACELLULAR-SUPEROXIDE DISMUTASE; NITRIC-OXIDE SYNTHASE; NADPH
   OXIDASE; OXIDIZED LDL; LIPID-PEROXIDATION; MEDITERRANEAN DIET;
   HEART-DISEASE; INDEPENDENT PREDICTOR
AB The role of oxidative stress in the onset and progression of atherosclerosis and its impact on the development of cardiovascular events has been widely described.
   Thus, increased oxidative stress has been described in several atherosclerotic risk factors, such as hypertension, dyslipidaemia, peripheral artery disease, metabolic syndrome, diabetes, and obesity.
   Among others, specific oxidative pathways involving both pro-oxidant and antioxidant enzymes seem to play a major role in the production of reactive oxidant species (ROS), such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, myeloperoxidase, superoxide dismutase, and glutathione peroxidase.
   In this review, we will discuss: 1) the most relevant enzyme systems involved in the formation and detoxification of ROS, 2) the relationship between oxidative stress and cardiovascular risk, and 3) therapeutic implications to modulate oxidative stress.
C1 [Pignatelli, Pasquale; Menichelli, Danilo; Pastori, Daniele; Violi, Francesco] Sapienza Univ Rome, Atherothrombosis Ctr, Clin Med 1, Dept Internal Med & Med Specialties, Rome, Italy.
C3 Sapienza University Rome
RP Violi, F (corresponding author), 1 Clin Med, Viale Policlin 155, I-00161 Rome, Italy.
EM francesco.violi@uniroma1.it
RI Violi, Francesco/K-1509-2016; pastori, daniele/J-7087-2016; Menichelli,
   Danilo/W-5498-2018; pignatelli, pasquale/K-2116-2016
OI pastori, daniele/0000-0001-6357-5213; Menichelli,
   Danilo/0000-0001-9467-5903; pignatelli, pasquale/0000-0002-2265-7455
CR Aiello RJ, 2002, ARTERIOSCL THROM VAS, V22, P443, DOI 10.1161/hq0302.105593
   Ali Z, 2009, VASC MED, V14, P215, DOI 10.1177/1358863X08101999
   Arca M, 2008, ARTERIOSCL THROM VAS, V28, P752, DOI 10.1161/ATVBAHA.107.154823
   Azumi H, 1999, CIRCULATION, V100, P1494, DOI 10.1161/01.CIR.100.14.1494
   Bäck M, 2005, P NATL ACAD SCI USA, V102, P17501, DOI 10.1073/pnas.0505845102
   Bäck M, 2009, CARDIOVASC DRUG THER, V23, P41, DOI 10.1007/s10557-008-6140-9
   Baldus S, 2003, CIRCULATION, V108, P1440, DOI 10.1161/01.CIR.0000090690.67322.51
   Ballinger SW, 2002, CIRCULATION, V106, P544, DOI 10.1161/01.CIR.0000023921.93743.89
   Barry-Lane PA, 2001, J CLIN INVEST, V108, P1513, DOI 10.1172/JCI200111927
   Basili S, 2014, DIGEST LIVER DIS, V46, P632, DOI 10.1016/j.dld.2014.02.021
   Basu S, 2008, ANTIOXID REDOX SIGN, V10, P1405, DOI 10.1089/ars.2007.1956
   Bertazzi PA, 2014, ANTIOXID REDOX SIGN, V21, P46, DOI 10.1089/ars.2013.5694
   Brennan M, 2003, NEW ENGL J MED, V349, P1595, DOI 10.1056/NEJMoa035003
   Brevetti G, 2008, EUR HEART J, V29, P224, DOI 10.1093/eurheartj/ehm587
   Cangemi R, 2013, INT J CARDIOL, V168, P3241, DOI 10.1016/j.ijcard.2013.04.142
   Carnevale R, 2016, CHEST, V150, P606, DOI 10.1016/j.chest.2016.04.012
   Carnevale R, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.114.000920
   Carnevale R, 2013, J AM HEART ASSOC, V2, DOI 10.1161/JAHA.113.000198
   Carr AC, 2000, ARTERIOSCL THROM VAS, V20, P1716, DOI 10.1161/01.ATV.20.7.1716
   Channon KM, 2004, TRENDS CARDIOVAS MED, V14, P323, DOI 10.1016/j.tcm.2004.10.003
   Chen M, 2013, J CARDIOVASC PHARM, V62, P320, DOI 10.1097/FJC.0b013e31829be05b
   Cipollone F, 2000, CIRCULATION, V102, P1007, DOI 10.1161/01.CIR.102.9.1007
   Cyrus T, 2001, CIRCULATION, V103, P2277
   DAUGHERTY A, 1994, J CLIN INVEST, V94, P437, DOI 10.1172/JCI117342
   Davi G, 2005, ANTIOXID REDOX SIGN, V7, P256, DOI 10.1089/ars.2005.7.256
   Davì G, 2002, JAMA-J AM MED ASSOC, V288, P2008, DOI 10.1001/jama.288.16.2008
   Davì G, 1999, CIRCULATION, V99, P224
   deLorgeril M, 1996, J AM COLL CARDIOL, V28, P1103, DOI 10.1016/S0735-1097(96)00280-X
   Devarajan A, 2011, ANTIOXID REDOX SIGN, V14, P341, DOI 10.1089/ars.2010.3430
   Ehara S, 2001, CIRCULATION, V103, P1955, DOI 10.1161/01.cir.103.15.1955
   Estruch R, 2013, NEW ENGL J MED, V368, P1279, DOI 10.1056/NEJMoa1200303
   Funk CD, 2002, PROSTAG OTH LIPID M, V68-9, P303, DOI 10.1016/S0090-6980(02)00036-9
   Garramone A, 2018, INTERN EMERG MED, V13, P183, DOI 10.1007/s11739-017-1750-5
   Germanò G, 2004, J HYPERTENS, V22, P1151, DOI 10.1097/01.hjh.0000125411.50839.6e
   GEY KF, 1991, AM J CLIN NUTR, V53, pS326, DOI 10.1093/ajcn/53.1.326S
   Guo Z, 2008, FREE RADICAL BIO MED, V44, P343, DOI 10.1016/j.freeradbiomed.2007.09.009
   Holvoet P, 1998, CIRCULATION, V98, P1487, DOI 10.1161/01.CIR.98.15.1487
   Holvoet P, 2004, DIABETES, V53, P1068, DOI 10.2337/diabetes.53.4.1068
   Johnston N, 2006, INT J CARDIOL, V113, P167, DOI 10.1016/j.ijcard.2005.11.006
   Judkins CP, 2010, AM J PHYSIOL-HEART C, V298, pH24, DOI 10.1152/ajpheart.00799.2009
   Kaviarasan S, 2009, J CLIN BIOCHEM NUTR, V45, P1, DOI 10.3164/jcbn.08-266
   Khan SQ, 2007, HEART, V93, P826, DOI 10.1136/hrt.2006.091041
   Kim JY, 2008, AM J CLIN NUTR, V88, P630, DOI 10.1093/ajcn/88.3.630
   Koenig W, 2011, CLIN CHEM, V57, P1196, DOI 10.1373/clinchem.2011.165134
   Kuhlencordt PJ, 2001, CIRCULATION, V104, P448, DOI 10.1161/hc2901.091399
   Kuhns DB, 2010, NEW ENGL J MED, V363, P2600, DOI 10.1056/NEJMoa1007097
   Kutter D, 2000, ACTA HAEMATOL-BASEL, V104, P10, DOI 10.1159/000041062
   Laukkanen MO, 2000, GENE, V254, P173, DOI 10.1016/S0378-1119(00)00272-9
   LeLeiko RM, 2009, AM J CARDIOL, V104, P638, DOI 10.1016/j.amjcard.2009.04.047
   Levitan I, 2010, ANTIOXID REDOX SIGN, V13, P39, DOI 10.1089/ars.2009.2733
   Lim SS, 2012, LANCET, V380, P2224, DOI 10.1016/S0140-6736(12)61766-8
   Liu YN, 2013, CIRC-CARDIOVASC IMAG, V6, P74, DOI 10.1161/CIRCIMAGING.112.975193
   Loffredo L, 2013, INT J CARDIOL, V165, P184, DOI 10.1016/j.ijcard.2012.01.069
   Loffredo L, 2013, ANTIOXID REDOX SIGN, V18, P1491, DOI 10.1089/ars.2012.4987
   Madamanchi NR, 2005, ARTERIOSCL THROM VAS, V25, P950, DOI 10.1161/01.ATV.0000161050.77646.68
   Mocatta TJ, 2007, J AM COLL CARDIOL, V49, P1993, DOI 10.1016/j.jacc.2007.02.040
   Morrow DA, 2008, EUR HEART J, V29, P1096, DOI 10.1093/eurheartj/ehn071
   Niemann B, 2017, J AM COLL CARDIOL, V70, P230, DOI 10.1016/j.jacc.2017.05.043
   Pastori D, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.116.003682
   Pastori D, 2016, ANTIOXID REDOX SIGN, V25, P751, DOI 10.1089/ars.2016.6839
   Pastori D, 2015, ANTIOXID REDOX SIGN, V23, P682, DOI 10.1089/ars.2015.6326
   Pastori D, 2014, INTERN EMERG MED, V9, P123, DOI 10.1007/s11739-013-0999-6
   Peters EA, 2001, FREE RADICAL BIO MED, V31, P1442, DOI 10.1016/S0891-5849(01)00725-0
   Pignatelli P, 2007, J THROMB HAEMOST, V5, P1170, DOI 10.1111/j.1538-7836.2007.02533.x
   Pignatelli P, 2009, ATHEROSCLEROSIS, V205, P239, DOI 10.1016/j.atherosclerosis.2008.10.025
   Pignatelli P, 2015, THROMB HAEMOSTASIS, V113, P617, DOI 10.1160/TH14-07-0571
   Pignatelli P, 2012, BIOCHEM PHARMACOL, V84, P1635, DOI 10.1016/j.bcp.2012.09.011
   Pignatelli P, 2012, CIRCULATION, V126, P92, DOI 10.1161/CIRCULATIONAHA.112.095554
   Pignatelli P, 2011, ARTERIOSCL THROM VAS, V31, P423, DOI 10.1161/ATVBAHA.110.217885
   Quesada IM, 2015, ATHEROSCLEROSIS, V242, P469, DOI 10.1016/j.atherosclerosis.2015.08.011
   Rose AH, 2015, THROMB HAEMOSTASIS, V113, P494, DOI 10.1160/TH14-07-0603
   Schürks M, 2010, BMJ-BRIT MED J, V341, DOI 10.1136/bmj.c5702
   Shih DM, 2007, CIRC RES, V100, P1200, DOI 10.1161/01.RES.0000264499.48737.69
   Shih DM, 1998, NATURE, V394, P284, DOI 10.1038/28406
   Shih DM, 2000, J BIOL CHEM, V275, P17527, DOI 10.1074/jbc.M910376199
   Shimada K, 2004, ATHEROSCLEROSIS, V174, P343, DOI 10.1016/j.atherosclerosis.2004.01.029
   Shishehbor MH, 2006, FREE RADICAL BIO MED, V41, P1678, DOI 10.1016/j.freeradbiomed.2006.09.001
   Sibley CT, 2014, CIRCULATION, V130, P2031, DOI 10.1161/CIRCULATIONAHA.113.006824
   Sies H, 2015, REDOX BIOL, V4, P180, DOI 10.1016/j.redox.2015.01.002
   SINGH RB, 1995, AM J CARDIOL, V76, P1233, DOI 10.1016/S0002-9149(99)80348-8
   Stefanska J, 2012, EXP LUNG RES, V38, P90, DOI 10.3109/01902148.2011.649823
   Stefanska J, 2010, PULM PHARMACOL THER, V23, P48, DOI 10.1016/j.pupt.2009.09.003
   Takatsu H, 2001, BIOCHEM BIOPH RES CO, V285, P84, DOI 10.1006/bbrc.2001.5114
   Tang WHW, 2006, AM J CARDIOL, V98, P796, DOI 10.1016/j.amjcard.2006.04.018
   Torzewski M, 2007, ARTERIOSCL THROM VAS, V27, P850, DOI 10.1161/01.ATV.0000258809.47285.07
   Tsai IJ, 2009, FREE RADICAL BIO MED, V46, P263, DOI 10.1016/j.freeradbiomed.2008.10.028
   Vassalle C, 2004, J INTERN MED, V256, P308, DOI 10.1111/j.1365-2796.2004.01373.x
   Violi F, 2017, ANTIOXID REDOX SIGN, V27, P1083, DOI 10.1089/ars.2016.6963
   Violi F, 2017, ARTERIOSCL THROM VAS, V37, P218, DOI 10.1161/ATVBAHA.116.308351
   Violi F, 2015, ANTIOXID REDOX SIGN, V23, P514, DOI 10.1089/ars.2013.5790
   Violi F, 2013, ARTERIOSCL THROM VAS, V33, P406, DOI 10.1161/ATVBAHA.112.300438
   Violi F, 2010, CIRCULATION, V121, P1033, DOI 10.1161/CIRCULATIONAHA.109.880211
   Violi F, 2009, CIRCULATION, V120, P1616, DOI 10.1161/CIRCULATIONAHA.109.877191
   Wang B, 2006, ATHEROSCLEROSIS, V184, P425, DOI 10.1016/j.atherosclerosis.2005.05.008
   Wang XL, 1998, ARTERIOSCL THROM VAS, V18, P1915, DOI 10.1161/01.ATV.18.12.1915
   Wilson PWF, 2006, ATHEROSCLEROSIS, V189, P364, DOI 10.1016/j.atherosclerosis.2005.12.013
   Wu TY, 2006, J AM COLL CARDIOL, V48, P973, DOI 10.1016/j.jacc.2006.03.057
   Yang H, 2004, CIRC RES, V95, P1075, DOI 10.1161/01.RES.0000149564.49410.0d
   Zhang RL, 2002, J BIOL CHEM, V277, P46116, DOI 10.1074/jbc.M209124200
   Zhang ZL, 2001, JAMA-J AM MED ASSOC, V286, P2136, DOI 10.1001/jama.286.17.2136
NR 100
TC 160
Z9 173
U1 6
U2 78
PU POLISH CARDIAC SOC-POLSKIE TOWARZYSTWO KARDIOLOGICZNE
PI WARSZAWA
PA UL STAWKI 3 A LOK 1-2, WARSZAWA, POLAND
SN 0022-9032
EI 1897-4279
J9 KARDIOL POL
JI Kardiol. Pol.
PY 2018
VL 76
IS 4
BP 713
EP 722
DI 10.5603/KP.a2018.0071
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GC8KC
UT WOS:000430041800004
PM 29537483
DA 2025-06-11
ER

PT J
AU Beebe-Dimmer, JL
   Ruterbusch, JJ
   Harper, FWK
   Baird, TM
   Finlay, DG
   Rundle, AG
   Pandolfi, SS
   Hastert, TA
   Schwartz, KL
   Bepler, G
   Simon, MS
   Mantey, J
   Abrams, J
   Albrecht, TL
   Schwartz, AG
AF Beebe-Dimmer, Jennifer L.
   Ruterbusch, Julie J.
   Harper, Felicity W. K.
   Baird, Tara M.
   Finlay, David G.
   Rundle, Andrew G.
   Pandolfi, Stephanie S.
   Hastert, Theresa A.
   Schwartz, Kendra L.
   Bepler, Gerold
   Simon, Michael S.
   Mantey, Julia
   Abrams, Judy
   Albrecht, Teri L.
   Schwartz, Ann G.
TI Physical activity and quality of life in African American cancer
   survivors: The Detroit Research on Cancer Survivors study
SO CANCER
LA English
DT Article
DE anxiety; breast cancer; colorectal cancer; depression; exercise; health
   disparities; lung cancer; prostate cancer
ID BREAST-CANCER; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; INDUCED
   CARDIOTOXICITY; TUMOR CHARACTERISTICS; RACIAL DISPARITIES; ETHNIC
   DISPARITIES; RISK; METAANALYSIS; RELIABILITY
AB Background The benefit of regular exercise in improving cancer outcomes is well established. The American Cancer Society (ACS) released a recommendation that cancer survivors should engage in at least 150 minutes of moderate to vigorous physical activity (PA) per week; however, few report meeting this recommendation. This study examined the patterns and correlates of meeting ACS PA recommendations in the Detroit Research on Cancer Survivors (ROCS) cohort of African American cancer survivors.
   Methods Detroit ROCS participants completed baseline and yearly follow-up surveys to update their health and health behaviors, including PA. This study examined participation in PA by select characteristics and reported health-related quality of life (HRQOL) as measured with the Functional Assessment of Cancer Therapy and Patient-Reported Outcomes Measurement Information System instruments.
   Results Among the first 1500 ROCS participants, 60% reported participating in regular PA, with 24% reporting >= 150 min/wk. Although there were no differences by sex, prostate cancer survivors were the most likely to report participating in regular PA, whereas lung cancer survivors were the least likely (P = .022). Survivors who reported participating in regular PA reported higher HRQOL (P < .001) and lower depression (P = .040).
   Conclusions Just 24% of African American cancer survivors reported meeting the ACS guidelines for PA at the baseline, but it was encouraging to see increases in activity over time. Because of the established benefits of regular exercise observed in this study and others, identifying and reducing barriers to regular PA among African American cancer survivors are critical for improving outcomes and minimizing disparities.
C1 [Beebe-Dimmer, Jennifer L.; Ruterbusch, Julie J.; Harper, Felicity W. K.; Baird, Tara M.; Finlay, David G.; Pandolfi, Stephanie S.; Hastert, Theresa A.; Schwartz, Kendra L.; Bepler, Gerold; Simon, Michael S.; Mantey, Julia; Abrams, Judy; Albrecht, Teri L.; Schwartz, Ann G.] Barbara Ann Karmanos Canc Inst, 4100 John R St, Detroit, MI 48201 USA.
   [Beebe-Dimmer, Jennifer L.; Ruterbusch, Julie J.; Harper, Felicity W. K.; Baird, Tara M.; Pandolfi, Stephanie S.; Hastert, Theresa A.; Schwartz, Kendra L.; Bepler, Gerold; Simon, Michael S.; Mantey, Julia; Abrams, Judy; Albrecht, Teri L.; Schwartz, Ann G.] Wayne State Sch Med, Dept Oncol, Detroit, MI USA.
   [Rundle, Andrew G.] Columbia Univ, Mailman Sch Publ Hlth, New York, NY USA.
C3 Barbara Ann Karmanos Cancer Institute; Wayne State University; Columbia
   University
RP Beebe-Dimmer, JL (corresponding author), Barbara Ann Karmanos Canc Inst, 4100 John R St, Detroit, MI 48201 USA.
EM dimmerj@karmanos.org
RI Harper, Felicity/AAE-3601-2019; Rundle, Andrew/A-5282-2009
OI Rundle, Andrew/0000-0003-0211-7707
FU National Cancer Institute of the National Institutes of Health [U01
   CA199240, P30 CA022453]; Barbara Ann Karmanos Cancer Institute;
   Metropolitan Detroit Cancer Surveillance System (Detroit Surveillance,
   Epidemiology, and End Results Cancer Registry) [HHSN-261201300011I];
   General Motors Foundation
FX This work was supported by the National Cancer Institute of the National
   Institutes of Health (U01 CA199240 and P30 CA022453), the Barbara Ann
   Karmanos Cancer Institute, the Metropolitan Detroit Cancer Surveillance
   System (Detroit Surveillance, Epidemiology, and End Results Cancer
   Registry contract HHSN-261201300011I), and the General Motors
   Foundation.
CR Ashing-Giwa K, 2013, QUAL LIFE RES, V22, P295, DOI 10.1007/s11136-012-0140-8
   Beebe-Dimmer JL, 2007, CANCER-AM CANCER SOC, V109, P875, DOI 10.1002/cncr.22461
   Beebe-Dimmer JL, 2019, CANCER EPIDEM BIOMAR, V28, P666, DOI 10.1158/1055-9965.EPI-18-0123
   Bradshaw PT, 2016, EPIDEMIOLOGY, V27, P6, DOI 10.1097/EDE.0000000000000394
   Buffart LM, 2017, CANCER TREAT REV, V52, P91, DOI 10.1016/j.ctrv.2016.11.010
   CELLA DF, 1993, J CLIN ONCOL, V11, P570, DOI 10.1200/JCO.1993.11.3.570
   Cho H, 2013, AM J EPIDEMIOL, V178, P339, DOI 10.1093/aje/kws580
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   Darby SC, 2013, NEW ENGL J MED, V368, P987, DOI 10.1056/NEJMoa1209825
   Demark-Wahnefried W, 2018, CA-CANCER J CLIN, V68, P64, DOI 10.3322/caac.21441
   DeSantis CE, 2019, CA-CANCER J CLIN, V69, P211, DOI 10.3322/caac.21555
   Ellis L, 2018, J CLIN ONCOL, V36, P25, DOI 10.1200/JCO.2017.74.2049
   Esposito K, 2012, DIABETES CARE, V35, P2402, DOI 10.2337/dc12-0336
   Ferrer RA, 2011, ANN BEHAV MED, V41, P32, DOI 10.1007/s12160-010-9225-1
   Glenn BA, 2018, J PSYCHOSOC ONCOL, V36, P418, DOI 10.1080/07347332.2018.1448031
   Hammarsten J, 2018, NAT REV UROL, V15, P321, DOI 10.1038/nrurol.2018.8
   Iyengar NM, 2016, J CLIN ONCOL, V34, P4270, DOI 10.1200/JCO.2016.67.4283
   Jemal A, 2007, CA-CANCER J CLIN, V57, P43, DOI 10.3322/canjclin.57.1.43
   Jensen RE, 2015, QUAL LIFE RES, V24, P2333, DOI 10.1007/s11136-015-0992-9
   Kabat GC, 2017, CANCER EPIDEM BIOMAR, V26, P1730, DOI 10.1158/1055-9965.EPI-17-0495
   Keating NL, 2006, J CLIN ONCOL, V24, P4448, DOI 10.1200/JCO.2006.06.2497
   Lee RE, 2011, J COMMUN HEALTH, V36, P1011, DOI 10.1007/s10900-011-9403-5
   Mihalcea DJ, 2017, AM J THER, V24, pE3, DOI 10.1097/MJT.0000000000000453
   Miller KD, 2016, CA-CANCER J CLIN, V66, P271, DOI 10.3322/caac.21349
   Morris AM, 2010, J AM COLL SURGEONS, V211, P105, DOI 10.1016/j.jamcollsurg.2010.02.051
   Nicolazzi MA, 2018, EUR REV MED PHARMACO, V22, P2175, DOI 10.26355/eurrev_201804_14752
   Park NJ, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184174
   Patnaik JL, 2011, BREAST CANCER RES, V13, DOI 10.1186/bcr2901
   Paxton RJ, 2019, FRONT ONCOL, V9, DOI 10.3389/fonc.2019.00003
   Paxton RJ, 2012, CANCER-AM CANCER SOC, V118, P4024, DOI 10.1002/cncr.27389
   Pietro Giuliano Di, 2016, Int Neurourol J, V20, pS112
   Quach CW, 2016, QUAL LIFE RES, V25, P2811, DOI 10.1007/s11136-016-1325-3
   Rock Cheryl L, 2012, CA Cancer J Clin, V62, P243, DOI 10.3322/caac.21142
   Schalet BD, 2016, J CLIN EPIDEMIOL, V73, P112, DOI 10.1016/j.jclinepi.2015.08.039
   Shavers VL, 2002, JNCI-J NATL CANCER I, V94, P334
   Silsbury Z, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2015-008430
   Simon MS, 2018, CANCER-AM CANCER SOC, V124, P1798, DOI 10.1002/cncr.31230
   Speck RM, 2010, J CANCER SURVIV, V4, P87, DOI 10.1007/s11764-009-0110-5
   Tao L, 2015, CANCER EPIDEM BIOMAR, V24, P1039, DOI 10.1158/1055-9965.EPI-15-0243
   Tarasenko Y, 2017, J AM GERIATR SOC, V65, pE39, DOI 10.1111/jgs.14589
   Tarasenko YN, 2018, CANCER CAUSE CONTROL, V29, P475, DOI 10.1007/s10552-018-1017-0
   van Veen MR, 2019, SUPPORT CARE CANCER, V27, P4565, DOI 10.1007/s00520-019-04735-y
   Warner ET, 2015, J CLIN ONCOL, V33, P2254, DOI 10.1200/JCO.2014.57.1349
   Webster Kimberly, 2003, Health Qual Life Outcomes, V1, P79, DOI 10.1186/1477-7525-1-79
   White A, 2010, CANCER-AM CANCER SOC, V116, P4622, DOI 10.1002/cncr.25395
NR 45
TC 35
Z9 38
U1 5
U2 35
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0008-543X
EI 1097-0142
J9 CANCER-AM CANCER SOC
JI Cancer
PD JAN 1
PY 2020
VL 126
IS 9
BP 1987
EP 1994
DI 10.1002/cncr.32725
EA FEB 2020
PG 8
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology
GA LC6DN
UT WOS:000515116100001
PM 32090322
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Cano-Ibáñez, N
   Serra-Majem, L
   Martín-Peláez, S
   Martínez-González, MA
   Salas-Salvadó, J
   Piquer, MDC
   Lassale, C
   Hernandez, JAM
   Alonso-Gómez, AM
   Wärnberg, J
   Lopez, JV
   Romaguera, D
   López-Miranda, J
   Estruch, R
   Gómez-Pérez, AM
   Santos-Lozano, JM
   Fernández-Aranda, F
   Bueno-Cavanillas, A
   Tur, JA
   Martín, V
   Sala, XP
   Delgado-Rodríguez, M
   Martín, PM
   Vidal, J
   Cárdenas, JJ
   Ruiz, LD
   Ros, E
   Buil-Cosiales, P
   Becerra-Tomás, N
   Saiz, C
   Muñoz-Perez, MA
   Abete, I
   Tojal-Sierra, L
   Fernández-Barceló, O
   Bernabé-Casanova, A
   Konieczna, J
   García-Ríos, A
   Casas, R
   Bernal-López, MR
   Lapetra, J
   Toledo, E
   Gómez-Martínez, C
   Coltell, O
   Malcampo-Manrúbia, M
   Zulet, MA
   Sorto-Sánchez, C
   Gea, A
   Hernández-Fleta, JL
   Niño, OC
   Sánchez-Villegas, A
AF Cano-Ibanez, Naomi
   Serra-Majem, Lluis
   Martin-Pelaez, Sandra
   Angel Martinez-Gonzalez, Miguel
   Salas-Salvado, Jordi
   Corella Piquer, Maria Dolores
   Lassale, Camille
   Martinez Hernandez, Jose Alfredo
   Alonso-Gomez, Angel M.
   Warnberg, Julia
   Vioque Lopez, Jesus
   Romaguera, Dora
   Lopez-Miranda, Jose
   Estruch, Ramon
   Maria Gomez-Perez, Ana
   Manuel Santos-Lozano, Jose
   Fernandez-Aranda, Fernando
   Bueno-Cavanillas, Aurora
   Tur, Josep A.
   Martin, Vicente
   Pinto Sala, Xavier
   Delgado-Rodriguez, Miguel
   Matia Martin, Pilar
   Vidal, Josep
   Cardenas, Jersy J.
   Daimiel Ruiz, Lidia
   Ros, Emilio
   Buil-Cosiales, Pilar
   Becerra-Tomas, Nerea
   Saiz, Carmen
   Munoz-Perez, Miguel-Angel
   Abete, Itziar
   Tojal-Sierra, Lucas
   Fernandez-Barcelo, Olga
   Bernabe-Casanova, Andrea
   Konieczna, Jadwiga
   Garcia-Rios, Antonio
   Casas, Rosa
   Rosa Bernal-Lopez, Maria
   Lapetra, Jose
   Toledo, Estefania
   Gomez-Martinez, Carlos
   Coltell, Oscar
   Malcampo-Manrubia, Mireia
   Angeles Zulet, Maria
   Sorto-Sanchez, Carolina
   Gea, Alfredo
   Luis Hernandez-Fleta, Jose
   Castaner Nino, Olga
   Sanchez-Villegas, Almudena
TI Association between the Prime Diet Quality Score and depressive symptoms
   in a Mediterranean population with metabolic syndrome. Cross-sectional
   and 2-year follow-up assessment from PREDIMED-PLUS study
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Prime diet quality score; Depressive symptomatology; Metabolic syndrome;
   PREDIMED-plus study
ID PHYSICAL-ACTIVITY QUESTIONNAIRE; FOOD FREQUENCY QUESTIONNAIRE; PATTERNS;
   RISK; VALIDATION; DISEASE; METAANALYSIS; NUTRIENTS; BURDEN; BRAIN
AB The burden of depression is increasing worldwide, specifically in older adults. Unhealthy dietary patterns may partly explain this phenomenon. In the Spanish PREDIMED-Plus study, we explored (1) the cross-sectional association between the adherence to the Prime Diet Quality Score (PDQS), an a priori-defined high-quality food pattern, and the prevalence of depressive symptoms at baseline (cross-sectional analysis) and (2) the prospective association of baseline PDQS with changes in depressive symptomatology after 2 years of follow-up. After exclusions, we assessed 6612 participants in the cross-sectional analysis and 5523 participants in the prospective analysis. An energy-adjusted high-quality dietary score (PDQS) was assessed using a validated FFQ. The cross-sectional association between PDQS and the prevalence of depression or presence of depressive symptoms and the prospective changes in depressive symptoms were evaluated through multivariable regression models (logistic and linear models and mixed linear-effects models). PDQS was inversely associated with depressive status in the cross-sectional analysis. Participants in the highest quintile of PDQS (Q5) showed a significantly reduced odds of depression prevalence as compared to participants in the lowest quartile of PDQS (Q1) (OR (95 %) CI = 0 center dot 82 (0 center dot 68, 0 center dot 98))). The baseline prevalence of depression decreased across PDQS quintiles (P (for trend) = 0 center dot 015). A statistically significant association between PDQS and changes in depressive symptoms after 2-years follow-up was found (beta (95 %) CI = -0 center dot 67 z-score (-1 center dot 17, -0 center dot 18). A higher PDQS was cross-sectionally related to a lower depressive status. Nevertheless, the null finding in our prospective analysis raises the possibility of reverse causality. Further prospective investigation is required to ascertain the association between PDQS and changes in depressive symptoms along time.
C1 [Cano-Ibanez, Naomi; Martin-Pelaez, Sandra; Bueno-Cavanillas, Aurora] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain.
   [Cano-Ibanez, Naomi; Vioque Lopez, Jesus; Bueno-Cavanillas, Aurora; Martin, Vicente; Delgado-Rodriguez, Miguel; Buil-Cosiales, Pilar] Inst Hlth Carlos III, Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain.
   [Cano-Ibanez, Naomi; Martin-Pelaez, Sandra; Bueno-Cavanillas, Aurora] Inst Invest Biosanit Granada Ibs GRANADA, Granada, Spain.
   [Serra-Majem, Lluis; Angel Martinez-Gonzalez, Miguel; Salas-Salvado, Jordi; Corella Piquer, Maria Dolores; Lassale, Camille; Alonso-Gomez, Angel M.; Warnberg, Julia; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Maria Gomez-Perez, Ana; Manuel Santos-Lozano, Jose; Fernandez-Aranda, Fernando; Tur, Josep A.; Pinto Sala, Xavier; Ros, Emilio; Becerra-Tomas, Nerea; Saiz, Carmen; Abete, Itziar; Tojal-Sierra, Lucas; Fernandez-Barcelo, Olga; Konieczna, Jadwiga; Garcia-Rios, Antonio; Casas, Rosa; Rosa Bernal-Lopez, Maria; Lapetra, Jose; Toledo, Estefania; Gomez-Martinez, Carlos; Coltell, Oscar; Angeles Zulet, Maria; Sorto-Sanchez, Carolina; Gea, Alfredo; Sanchez-Villegas, Almudena] Inst Salud Carlos III ISCIII, MP Fisiopatol Obesidad & Nutr CIBERobn, Consorcio CIBER, Madrid, Spain.
   [Serra-Majem, Lluis; Sanchez-Villegas, Almudena] Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci IUIBS, Las Palmas Gran Canaria, Spain.
   [Angel Martinez-Gonzalez, Miguel; Buil-Cosiales, Pilar; Abete, Itziar; Toledo, Estefania; Angeles Zulet, Maria; Gea, Alfredo] Univ Navarra, Dept Prevent Med & Publ Hlth, IDISNA, Pamplona, Spain.
   [Angel Martinez-Gonzalez, Miguel] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
   [Salas-Salvado, Jordi; Becerra-Tomas, Nerea; Gomez-Martinez, Carlos] Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Unitat Nutr Humana, Reus, Spain.
   [Salas-Salvado, Jordi; Becerra-Tomas, Nerea; Gomez-Martinez, Carlos] Hosp Univ San Joan Reus, Human Nutr Unit, Reus, Spain.
   [Salas-Salvado, Jordi; Becerra-Tomas, Nerea; Gomez-Martinez, Carlos] Inst Invest Sanitaria Pere Virgili IISPV, Reus, Spain.
   [Corella Piquer, Maria Dolores; Saiz, Carmen] Univ Valencia, Dept Prevent Med, Valencia, Spain.
   [Lassale, Camille; Malcampo-Manrubia, Mireia; Castaner Nino, Olga] Hosp del Mar Med Res Inst IMIM, Cardiovasc Risk & Nutr Res Grp, Barcelona, Spain.
   [Martinez Hernandez, Jose Alfredo; Abete, Itziar; Angeles Zulet, Maria] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, IdisNA, Pamplona, Spain.
   [Martinez Hernandez, Jose Alfredo; Daimiel Ruiz, Lidia] CEI UAM CSIC, Nutr Control Epigenome Precis Nutr & Obes Program, Madrid, Spain.
   [Alonso-Gomez, Angel M.; Tojal-Sierra, Lucas; Sorto-Sanchez, Carolina] Univ Basque Country UPV EHU, Araba Univ Hosp, Bioaraba Hlth Res Inst, Cardiovasc Resp & Metab Area,Osakidetza Basque Hl, Vitoria, Spain.
   [Warnberg, Julia; Fernandez-Barcelo, Olga] Univ Malaga, Sch Hlth Sci, Dept Nursing, Inst Invest Biomed Malaga IBIMA, Malaga, Spain.
   [Vioque Lopez, Jesus] Inst Invest Sanitario & Biomed Alicante, ISABIAL UMH, Alicante, Spain.
   [Romaguera, Dora; Konieczna, Jadwiga] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca, Spain.
   [Lopez-Miranda, Jose; Garcia-Rios, Antonio] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Dept Internal Med, Cordoba, Spain.
   [Estruch, Ramon; Casas, Rosa] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Internal Med, Barcelona, Spain.
   [Maria Gomez-Perez, Ana; Rosa Bernal-Lopez, Maria] Univ Malaga, Virgen de la Victoria Hosp, Inst Invest Biomed Malga IBIMA, Dept Endocrinol, Malaga, Spain.
   [Manuel Santos-Lozano, Jose; Lapetra, Jose] Dist Sanitario Atenc Primaria Sevilla, Res Unit, Dept Family Med, Seville, Spain.
   [Fernandez-Aranda, Fernando] Univ Barcelona, Univ Hosp Bellvitge IDIBELL, Dept Psychiat, Barcelona, Spain.
   [Fernandez-Aranda, Fernando] Univ Barcelona, Sch Med & Hlth Sci, Barcelona, Spain.
   [Tur, Josep A.] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain.
   [Martin, Vicente] Univ Leon, Inst Biomed IBIOMED, Leon, Spain.
   [Pinto Sala, Xavier] Hosp Univ Bellvitge, Lipids & Vasc Risk Unit, Internal Med, Barcelona, Spain.
   [Delgado-Rodriguez, Miguel] Univ Jaen, Ctr Adv Studies Olive Grove & Olive Oils, Jaen, Spain.
   [Matia Martin, Pilar] Inst Invest Sanitaria Hosp Clin San Carlos IdISSC, Dept Endocrinol & Nutr, Madrid, Spain.
   [Vidal, Josep] Inst Salud Carlos III ISCIII, CIBER Diabet & Enfermedades Metab CIBERDEM, Madrid, Spain.
   [Vidal, Josep] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol, Barcelona, Spain.
   [Cardenas, Jersy J.] Univ Autonoma, Hosp Fdn Jimenez Diaz, Inst Invest Biomed IISFJD, Dept Endocrinol & Nutr, Madrid, Spain.
   [Ros, Emilio] Hosp Clin Barcelona, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol & Nutr, Lipid Clin, Barcelona, Spain.
   [Buil-Cosiales, Pilar] Inst Invest Sanitaria Navarra IdiSNA, Serv Navarro Salud Osasunbidea, Pamplona, Navarra, Spain.
   [Munoz-Perez, Miguel-Angel] Inst Catala Salut, Primary Care Div, Unitat Suport Recerca Atencio Primaria Barcelona, IDIAP Jordi Gol, Barcelona, Spain.
   [Bernabe-Casanova, Andrea] Ctr Salud Raval Elche, Alicante, Spain.
   [Coltell, Oscar] Univ Jaume 1, Dept Comp Languages & Syst, Castellon de La Plana, Spain.
   [Luis Hernandez-Fleta, Jose] Hosp Dr Negrin, Psychiat Serv, Las Palmas Gran Canaria, Spain.
   [Sanchez-Villegas, Almudena] Univ Publ Navarra UPNA, ISFOOD Inst Innovat & Sustainable Dev Food Chain, Inst Invest Sanitaria Navarra, IdiSNA, Pamplona, Spain.
C3 University of Granada; CIBER - Centro de Investigacion Biomedica en Red;
   CIBERESP; Instituto de Investigacion Biosanitaria IBS Granada;
   Universidad de Las Palmas de Gran Canaria; University of Navarra;
   Harvard University; Harvard T.H. Chan School of Public Health;
   Universitat Rovira i Virgili; Universitat Rovira i Virgili; Institut
   d'Investigacio Sanitaria Pere Virgili (IISPV); University of Valencia;
   Hospital del Mar Research Institute; Hospital del Mar; University of
   Navarra; Consejo Superior de Investigaciones Cientificas (CSIC);
   Bioaraba Health Research Institute; University Hospital of Araba;
   University of Basque Country; Instituto de Investigacion Biomedica de
   Malaga y Plataforma en Nanomedicina (IBIMA); Universidad de Malaga;
   General University Hospital of Alicante; Universidad Miguel Hernandez de
   Elche; Universitat d'Alacant; Instituto de Investigacion Sanitaria y
   Biomedica de Alicante (ISABIAL); Institut Investigacio Sanitaria Illes
   Balears (IdISBa); Universidad de Cordoba; University of Barcelona;
   Hospital Clinic de Barcelona; IDIBAPS; Universidad de Malaga; Instituto
   de Investigacion Biomedica de Malaga y Plataforma en Nanomedicina
   (IBIMA); University of Barcelona; Institut d'Investigacio Biomedica de
   Bellvitge (IDIBELL); Bellvitge University Hospital; University of
   Barcelona; Universitat de les Illes Balears; Universidad de Leon;
   Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge
   University Hospital; University of Barcelona; Universidad de Jaen; CIBER
   - Centro de Investigacion Biomedica en Red; CIBERDEM; University of
   Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Fundacion Jimenez
   Diaz; Autonomous University of Madrid; University of Barcelona; Hospital
   Clinic de Barcelona; IDIBAPS; Servicio Navarro de Salud - Osasunbidea;
   Universitat Jaume I; Universidad Publica de Navarra
RP Cano-Ibáñez, N (corresponding author), Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain.; Cano-Ibáñez, N (corresponding author), Inst Hlth Carlos III, Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain.; Cano-Ibáñez, N (corresponding author), Inst Invest Biosanit Granada Ibs GRANADA, Granada, Spain.
EM ncaiba@ugr.es
RI Sureda, Antoni/N-9588-2019; Tur, Josep/AAE-5748-2020; Martinez,
   Sandra/HSG-4592-2023; Sanchez-Villegas, Almudena/T-6733-2019;
   Bueno-Cavanillas, Aurora/O-1513-2015; Rodríguez, Miguel/KCZ-1828-2024;
   MARTIN-PELAEZ, SANDRA/G-4945-2015; ALONSO GOMEZ, ANGEL/HLG-2476-2023;
   Pintó, Xavier/AGI-4297-2022; Coltell, Oscar/AAA-9936-2019; Hernández
   Fleta, Jose Luis/IUM-7005-2023; Lassale, Camille/ABE-7813-2020;
   Castaner, Olga/F-1533-2013; Fernández-Barceló, Olga/AAO-6485-2021;
   Estruch, Ramon/AAZ-3723-2020; Lopez-Miranda, Jose/Y-8306-2019;
   Romaguera, Dora/ABE-7004-2020; Toledo, Estefania/H-6211-2014; Lapetra,
   Jose/F-2552-2015; Vidal, Josep/MIK-6936-2025; Warnberg,
   Julia/G-1390-2011; Abad-Gurumeta, Alfredo/M-2337-2019; Konieczna,
   Jadwiga/AAB-2817-2020; Casas, Rosa/ABD-1915-2020; Martinez-Gonzalez,
   Miguel/AAE-7669-2019; Salas-Salvado, Jordi/C-7229-2017; Martin,
   Vicente/A-1597-2008; Becerra-Tomas, Nerea/H-3937-2018; FERNANDEZ-ARANDA,
   FERNANDO/L-9762-2014; Delgado Rodriguez, Miguel/H-4940-2017;
   Daimiel-Ruiz, Lidia Angeles/M-7779-2014; Gomez Martinez,
   Carlos/AGJ-6387-2022
OI Tojal Sierra, Lucas/0000-0001-5338-9601; Cano-Ibanez,
   Naomi/0000-0002-3640-5486; Salas-Salvado, Jordi/0000-0003-2700-7459;
   Martin, Vicente/0000-0003-0552-2804; Becerra-Tomas,
   Nerea/0000-0002-4429-6507; Buil-Cosiales, Pilar/0000-0002-8586-577X;
   FERNANDEZ-ARANDA, FERNANDO/0000-0002-2968-9898; Munoz,
   Miguel-Angel/0000-0002-4083-3248; Delgado Rodriguez,
   Miguel/0000-0002-3838-2548; MARTIN PELAEZ, SANDRA/0000-0002-2193-3913;
   Hernandez Fleta, Jose Luis/0000-0001-8083-9647; Lassale,
   Camille/0000-0002-9340-2708; Daimiel-Ruiz, Lidia
   Angeles/0000-0001-9898-6629; Casas, Rosa/0000-0002-0211-9166; Sanchez
   Villegas, Almudena/0000-0001-7733-9238; Lopez-Miranda,
   Jose/0000-0002-8844-0718; Fernandez-Barcelo, Olga/0000-0002-7629-627X;
   Cardenas, Jersy Jair/0000-0002-2485-484X; Gomez Martinez,
   Carlos/0000-0002-3077-6702
FU European Research Council [340918]; Spanish Government, ISCIII through
   the Fondo de Investigacion para la Salud (FIS); European Regional
   Development Fund [PI13/00673, PI13/00492, PI13/00272, PI13/01123,
   PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056,
   PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919,
   PI14/00853, PI14/01374, PI16/00473]; Especial Action Project entitled:
   'Implementacion y Evaluacion de una intervencion intensiva sobre la
   actividad fisica Cohorte PREDIMED-Plus' [2013ACUP00194]; Consejeria de
   Salud de la Junta de Andalucia [PI0458/2013, PS0358/2016, PI0137/2018];
   Generalitat Valenciana; SEMERGEN grant; CIBEROBN and FEDER funds
   [CB06/03]; International Nut&Dried Fruit Council-FESNAD [201302];
   Department of Health, Generalitt de Cataluna by the calls "Accio
   instrumental de programes de recerca orientatsenlambit de la recercaila
   innovacio en salut" [SLT006/17/00246]; Pla estrategic de recerca i
   innovacio en salut (PERIS) [SLT006/17/00246]; EU
   [Eat2beNICE/h2020-sfs-2016-2, 728,018, PRIME/h2020-SC1-BHC2018-2020,
   847,879]; The European Regional Development Fund [PI16/00662,
   PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366,
   PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347,
   PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508,
   PI17/01732, PI17/00926]
FX The PREDIMED-Plus trial was supported by the European Research Council
   (Advanced Research Grant 2013-2018; 340918) grant to Miguel Angel
   Martinez-Gonzalez and by the official funding agency for biomedical
   research of the Spanish Government, ISCIII through the Fondo de
   Investigacion para la Salud (FIS), which is co-funded by the European
   Regional Development Fund (four coordinated FIS projects led by Jordi
   Salas-Salvado and Josep Vidal), including the following projects:
   PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233,
   PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636,
   PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374,
   PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533,
   PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183,
   PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215,
   PI17/01441, PI17/00508, PI17/01732 and PI17/00926. The Especial Action
   Project entitled: 'Implementacion y Evaluacion de una intervencion
   intensiva sobre la actividad fisica Cohorte PREDIMED-Plus' grant to
   Jordi Salas-Salvado, the Recercaixa grant to Jordi Salas-Salvado
   (2013ACUP00194), grants from the Consejeria de Salud de la Junta de
   Andalucia (PI0458/2013; PS0358/2016; PI0137/2018), the PROMETEO/2017/017
   grant from the Generalitat Valenciana, the SEMERGEN grant and CIBEROBN
   and FEDER funds (CB06/03), ISCIII. International Nut&Dried Fruit
   Council-FESNAD N degrees 201302: Miguel Angel Martinez-Gonzalez (PI).
   None of the funding sources took part in the design, collection,
   analysis or interpretation of the data or in the decision to submit the
   manuscript for publication. Fernando Fernandez-Aranda and the study was
   partially funded by the following grants: SLT006/17/00246, by the
   Department of Health, Generalitt de Cataluna by the calls "Accio
   instrumental de programes de recerca orientatsenlambit de la recercaila
   innovacio en salut" and "Pla estrategic de recerca i innovacio en salut
   (PERIS)". We thank CERCA Programme/Generalitt de Catalunya for
   institutional support. This research was also partially funded by
   EU-H2020 Grants (Eat2beNICE/h2020-sfs-2016-2; ref.728,018; and
   PRIME/h2020-SC1-BHC2018-2020; ref: 847,879) The corresponding author had
   full access to all the data in the study and had final responsibility to
   submit for publication.
CR Ainsworth BE, 2011, MED SCI SPORT EXER, V43, P1575, DOI 10.1249/MSS.0b013e31821ece12
   Akbaraly TN, 2016, CLIN PSYCHOL SCI, V4, P1125, DOI 10.1177/2167702616645777
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alvarez-Alvarez I, 2020, EUR J NUTR, V59, P1219, DOI 10.1007/s00394-019-01982-x
   Bergmans RS, 2017, PREV MED, V99, P313, DOI 10.1016/j.ypmed.2017.03.016
   Bourre JM, 2006, J NUTR HEALTH AGING, V10, P377
   Burrows K, 2020, J AFFECT DISORDERS, V263, P99, DOI 10.1016/j.jad.2019.11.160
   Dipnall JF, 2015, J AFFECT DISORDERS, V174, P215, DOI 10.1016/j.jad.2014.11.030
   ELOSUA R, 1994, AM J EPIDEMIOL, V139, P1197, DOI 10.1093/oxfordjournals.aje.a116966
   Elosua R, 2000, MED SCI SPORT EXER, V32, P1431, DOI 10.1097/00005768-200008000-00011
   Freeman MP, 2006, J CLIN PSYCHIAT, V67, P1954, DOI 10.4088/JCP.v67n1217
   Fung TT, 2018, AM J CLIN NUTR, V107, P120, DOI 10.1093/ajcn/nqx015
   Gibson-Smith D, 2018, J PSYCHIATR RES, V106, P1, DOI 10.1016/j.jpsychires.2018.09.006
   Gicevic S, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0195103
   Gómez-Pinilla F, 2008, NAT REV NEUROSCI, V9, P568, DOI 10.1038/nrn2421
   Hu FB, 2002, CURR OPIN LIPIDOL, V13, P3, DOI 10.1097/00041433-200202000-00002
   Ibáñez I, 2010, BEHAV PSYCHOL, V18, P35
   Konttinen H, 2010, APPETITE, V54, P473, DOI 10.1016/j.appet.2010.01.014
   Lai JS, 2014, AM J CLIN NUTR, V99, P181, DOI 10.3945/ajcn.113.069880
   Lang UE, 2015, CELL PHYSIOL BIOCHEM, V37, P1029, DOI 10.1159/000430229
   Lara E, 2015, REV PSIQUIATR SALUD, V8, P207, DOI 10.1016/j.rpsm.2014.09.001
   Li Y, 2017, PSYCHIAT RES, V253, P373, DOI 10.1016/j.psychres.2017.04.020
   Lopez AD, 2006, LANCET, V367, P1747, DOI 10.1016/S0140-6736(06)68770-9
   Martínez-Gonázlez MA, 2016, P NUTR SOC, V75, P139, DOI 10.1017/S0029665116000045
   Martínez-González MA, 2019, INT J EPIDEMIOL, V48, P387, DOI 10.1093/ije/dyy225
   MARTINMORENO JM, 1993, INT J EPIDEMIOL, V22, P512, DOI 10.1093/ije/22.3.512
   Miller AH, 2009, BIOL PSYCHIAT, V65, P732, DOI 10.1016/j.biopsych.2008.11.029
   Molendijk M, 2018, J AFFECT DISORDERS, V226, P346, DOI 10.1016/j.jad.2017.09.022
   Nanri A, 2020, CLIN NUTR, V39, P1951, DOI 10.1016/j.clnu.2019.08.021
   Nicolaou M, 2020, PSYCHOL MED, V50, P1872, DOI 10.1017/S0033291719001958
   Ortega Y, 2018, PRIM CARE DIABETES, V12, P163, DOI 10.1016/j.pcd.2017.09.002
   Quirk SE, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-175
   Rajapakshe OBW, 2019, PSYCHOGERIATRICS, V19, P202, DOI 10.1111/psyg.12389
   Rifas-Shiman SL, 2001, PUBLIC HEALTH NUTR, V4, P249, DOI 10.1079/PHN200061
   Sanchez-Villegas A, 2013, BMC MED, V11, DOI [10.1186/1741-7015-11-3, 10.1186/1741-7015-11-208]
   Schulze MB, 2003, BRIT J NUTR, V89, P409, DOI 10.1079/BJN2002778
   Skarupski KA, 2013, J NUTR HEALTH AGING, V17, P441, DOI 10.1007/s12603-012-0437-x
   Sobocki P, 2006, J MENT HEALTH POLICY, V9, P87
   Willet W., 2013, NUTR EPIDEMIOLOGY
   World Health Organization, 2017, Global Hepatitis Report 2017
NR 40
TC 12
Z9 12
U1 1
U2 17
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD SEP 28
PY 2022
VL 128
IS 6
BP 1170
EP 1179
AR PII S0007114521004323
DI 10.1017/S0007114521004323
EA OCT 2021
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 3U1FJ
UT WOS:000744721900001
PM 34713791
DA 2025-06-11
ER

PT J
AU Patel, PJ
   Hayward, KL
   Rudra, R
   Horsfall, LU
   Hossain, F
   Williams, S
   Johnson, T
   Brown, NN
   Saad, N
   Clouston, AD
   Stuart, KA
   Valery, PC
   Irvine, KM
   Russell, AW
   Powell, EE
AF Patel, Preya Janubhai
   Hayward, Kelly Lee
   Rudra, Rathiga
   Horsfall, Leigh Ula
   Hossain, Fabrina
   Williams, Suzanne
   Johnson, Tracey
   Brown, Nigel Neil
   Saad, Nivene
   Clouston, Andrew Donald
   Stuart, Katherine Anne
   Valery, Patricia Casarolli
   Irvine, Katharine Margaret
   Russell, Anthony William
   Powell, Elizabeth Ellen
TI Multimorbidity and polypharmacy in diabetic patients with NAFLD:
   Implications for disease severity and management
SO MEDICINE
LA English
DT Article
DE cirrhosis; liver disease; steatohepatitis; steatosis; transient
   elastography
ID FATTY LIVER-DISEASE; PROTON PUMP INHIBITORS; NONALCOHOLIC
   STEATOHEPATITIS; SIGNIFICANT FIBROSIS; RISK; MELLITUS; THERAPY; INJURY;
   DEPRESSION; ANXIETY
AB An observational study describing the number and type of chronic conditions and medications taken by diabetic patients with NAFLD and identifying characteristics that may impact liver disease severity or clinical management.Adults with type 2 diabetes have a high prevalence of nonalcoholic fatty liver disease (NAFLD) and increased risk of developing advanced liver disease. Appropriate management should consider the characteristics of the diabetic NAFLD population, as comorbid conditions and medications may increase the complexity of treatment strategies.Diabetic patients with NAFLD at risk of clinically significant liver disease (as assessed by the FIB-4 or NAFLD fibrosis scores) were recruited consecutively from the Endocrine clinic or primary care. Medical conditions, medication history, anthropometric measurements, and laboratory tests were obtained during assessment. NAFLD severity was classified by transient elastography and liver ultrasound into no advanced disease (LSM< 8.2 kPa) or clinically significant liver disease (LSM 8.2 kPa).The most common coexistent chronic conditions were metabolic syndrome (94%), self-reported depression (44%), ischaemic heart disease (32%), and obstructive sleep apnoea (32%). Polypharmacy or hyperpolypharmacy was present in 59% and 31% of patients respectively. Elevated LSM (8.2 kPa) suggesting significant liver disease was present in 37% of this at-risk cohort. Increasing obesity and abdominal girth were both independently associated with likelihood of having significant liver disease.There is a high burden of multimorbidity and polypharmacy in diabetic NAFLD patients, highlighting the importance of multidisciplinary management to address their complex health care needs and ensure optimal medical treatment.
C1 [Patel, Preya Janubhai; Horsfall, Leigh Ula; Stuart, Katherine Anne; Powell, Elizabeth Ellen] Univ Queensland, Princess Alexandra Hosp, Dept Gastroenterol & Hepatol, Brisbane, Qld, Australia.
   [Patel, Preya Janubhai; Rudra, Rathiga; Horsfall, Leigh Ula; Clouston, Andrew Donald; Irvine, Katharine Margaret; Powell, Elizabeth Ellen] Univ Queensland, Ctr Liver Dis Res, Translat Res Inst, Sch Med, Brisbane, Qld, Australia.
   [Hayward, Kelly Lee] Univ Queensland, Sch Med, Brisbane, Qld, Australia.
   [Hayward, Kelly Lee] Princess Alexandra Hosp, Pharm Dept, Brisbane, Qld, Australia.
   [Hossain, Fabrina; Williams, Suzanne; Johnson, Tracey] Princess Alexandra Hosp, Inala Primary Care, Brisbane, Qld, Australia.
   [Brown, Nigel Neil] Princess Alexandra Hosp, Pathol Queensland, Brisbane, Qld, Australia.
   [Saad, Nivene] Princess Alexandra Hosp, Dept Radiol, Brisbane, Qld, Australia.
   [Valery, Patricia Casarolli] Princess Alexandra Hosp, QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia.
   [Russell, Anthony William] Princess Alexandra Hosp, Dept Endocrinol, Brisbane, Qld, Australia.
C3 University of Queensland; Princess Alexandra Hospital; University of
   Queensland; University of Queensland; Princess Alexandra Hospital;
   Princess Alexandra Hospital; Princess Alexandra Hospital; Princess
   Alexandra Hospital; QIMR Berghofer Medical Research Institute; Princess
   Alexandra Hospital; Princess Alexandra Hospital
RP Powell, EE (corresponding author), Princess Alexandra Hosp, Dept Gastroenterol & Hepatol, Ipswich Rd, Woolloongabba, Qld 4102, Australia.
EM e.powell@uq.edu.au
RI Valery, Patricia/AAV-5448-2020; Clouston, Andrew/E-7199-2011; Valery,
   Patricia/G-6230-2013; Russell, Anthony/A-8807-2011; Powell,
   Elizabeth/B-4455-2011; Irvine, Katharine/A-5559-2011
OI Hayward, Kelly/0000-0001-6115-3420; Valery,
   Patricia/0000-0002-8823-3006; Russell, Anthony/0000-0003-4902-6693;
   Patel, Preya/0000-0002-2433-6794; Russell, Anthony/0000-0001-7886-8844;
   Powell, Elizabeth/0000-0001-5008-8061; Irvine,
   Katharine/0000-0002-6716-1605
FU Pathology Queensland-Study, Education and Research Trust Fund;
   Australian National Health and Medical Research Council [1083090]
FX This study was funded by the Pathology Queensland-Study, Education and
   Research Trust Fund.r PCV was supported by the Australian National
   Health and Medical Research Council (Career Development Fellowship
   #1083090).
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Angulo P, 2007, HEPATOLOGY, V45, P846, DOI 10.1002/hep.21496
   Anstee QM, 2013, NAT REV GASTRO HEPAT, V10, P330, DOI 10.1038/nrgastro.2013.41
   Aron-Wisnewsky J, 2016, METABOLISM, V65, P1124, DOI 10.1016/j.metabol.2016.05.004
   Beverly EA, 2011, DIABETIC MED, V28, P781, DOI 10.1111/j.1464-5491.2011.03282.x
   Bhatt DL, 2008, AM J GASTROENTEROL, V103, P2890, DOI 10.1111/j.1572-0241.2008.02216.x
   Brunt EM, 1999, AM J GASTROENTEROL, V94, P2467, DOI 10.1111/j.1572-0241.1999.01377.x
   Bugianesi E, 2005, AM J GASTROENTEROL, V100, P1082, DOI 10.1111/j.1572-0241.2005.41583.x
   Byrne CD, 2015, J HEPATOL, V62, pS47, DOI 10.1016/j.jhep.2014.12.012
   Calderón-Larrañaga A, 2016, INT J CARDIOL, V207, P310, DOI 10.1016/j.ijcard.2016.01.069
   Carbone LJ, 2016, J GASTROEN HEPATOL, V31, P23, DOI 10.1111/jgh.13026
   Cassinotto C, 2016, HEPATOLOGY, V63, P1817, DOI 10.1002/hep.28394
   Cusi K, 2016, DIABETOLOGIA, V59, P1112, DOI 10.1007/s00125-016-3952-1
   Dongiovanni P, 2015, J HEPATOL, V63, P705, DOI 10.1016/j.jhep.2015.05.006
   Eslami L, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008623.pub2
   Fromenty B, 2013, J HEPATOL, V58, P824, DOI 10.1016/j.jhep.2012.12.018
   Georgescu EF, 2008, ADV THER, V25, P1141, DOI 10.1007/s12325-008-0110-2
   Gruneir A, 2016, CAN J DIABETES, V40, P35, DOI 10.1016/j.jcjd.2015.09.002
   Harrison SA, 2015, HEPATOLOGY, V62, P1652, DOI 10.1002/hep.28275
   Hayward K, 2015, J GASTROEN HEPATOL, V30, P101
   Imhann F, 2016, GUT, V65, P740, DOI 10.1136/gutjnl-2015-310376
   Kahn SE, 2006, NATURE, V444, P840, DOI 10.1038/nature05482
   Kennedy M, 2013, AUST FAM PHYSICIAN, V42, P207
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Lemoine M, 2012, J HEPATOL, V56, P20, DOI 10.1016/j.jhep.2011.09.002
   Leung C, 2016, NAT REV GASTRO HEPAT, V13, P412, DOI 10.1038/nrgastro.2016.85
   Lewis PO, 2016, PHARMACOTHERAPY, V36, P986, DOI 10.1002/phar.1801
   Lonardo A, 2016, METABOLISM, V65, P1136, DOI 10.1016/j.metabol.2015.09.017
   Lonardo A, 2015, DIGEST LIVER DIS, V47, P997, DOI 10.1016/j.dld.2015.08.004
   Mastromarino Vittoria, 2014, Curr Heart Fail Rep, V11, P212, DOI 10.1007/s11897-014-0186-8
   McPherson S, 2010, GUT, V59, P1265, DOI 10.1136/gut.2010.216077
   Michaut A, 2016, TOXICOL APPL PHARM, V292, P40, DOI 10.1016/j.taap.2015.12.020
   Nascimbeni F, 2016, BMJ OPEN GASTROENTER, V3, DOI 10.1136/bmjgast-2015-000075
   Neuschwander-Tetri BA, 2015, LANCET, V385, P956, DOI 10.1016/S0140-6736(14)61933-4
   Pastori D, 2015, DIGEST LIVER DIS, V47, P4, DOI 10.1016/j.dld.2014.07.170
   Piette JD, 2006, DIABETES CARE, V29, P725, DOI 10.2337/diacare.29.03.06.dc05-2078
   Piva SR, 2015, CLIN GERIATR MED, V31, P67, DOI 10.1016/j.cger.2014.08.019
   Saadeh S, 2002, GASTROENTEROLOGY, V123, P745, DOI 10.1053/gast.2002.35354
   Schneider M, 2017, NEUROSCI BIOBEHAV R, V76, P336, DOI 10.1016/j.neubiorev.2016.06.002
   Simpson SH, 2006, BMJ-BRIT MED J, V333, P15, DOI 10.1136/bmj.38875.675486.55
   Sterling RK, 2006, HEPATOLOGY, V43, P1317, DOI 10.1002/hep.21178
   Stewart KE, 2015, LIVER INT, V35, P936, DOI 10.1111/liv.12483
   Strekalova T, 2015, BRAIN BEHAV IMMUN, V48, P42, DOI 10.1016/j.bbi.2015.02.015
   Tarantino G, 2007, HEPATOL RES, V37, P410, DOI 10.1111/j.1872-034X.2007.00072.x
   Teljeur C, 2013, EUR J GEN PRACT, V19, P17, DOI 10.3109/13814788.2012.714768
   Tran-Duy A, 2015, INT J CLIN PRACT, V69, P1088, DOI 10.1111/ijcp.12634
   World Health Organization, diagnosis of diabetes mellitus and intermediate hyperglycaemia: report of a
   Yang YX, 2006, JAMA-J AM MED ASSOC, V296, P2947, DOI 10.1001/jama.296.24.2947
   Youssef NA, 2013, LIVER INT, V33, P1062, DOI 10.1111/liv.12165
   Yu SJ, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000002159
   Zoppini G, 2014, AM J GASTROENTEROL, V109, P1020, DOI 10.1038/ajg.2014.132
NR 51
TC 42
Z9 43
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUN
PY 2017
VL 96
IS 26
AR e6761
DI 10.1097/MD.0000000000006761
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EZ8FB
UT WOS:000404958900002
PM 28658094
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Grover, S
   Chakrabarti, S
   Sahoo, S
AF Grover, Sandeep
   Chakrabarti, Subho
   Sahoo, Swapnajeet
TI Prevalence and clinical correlates of residual symptoms in remitted
   patients with bipolar disorder: An exploratory study
SO INDIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Bipolar disorder; depression; mania; residual symptoms
ID SUBSYNDROMAL DEPRESSIVE SYMPTOMS; TREATMENT ENHANCEMENT PROGRAM;
   RATING-SCALE; METABOLIC SYNDROME; SLEEP DISTURBANCE; NATURAL-HISTORY;
   ILLNESS COURSE; MOOD SYMPTOMS; CLOZAPINE; THERAPY
AB Objective: This cross-sectional study aimed to evaluate the prevalence and factors associated with residual symptoms (both depressive and manic) in subjects with bipolar disorder (BD). Materials and Methods: A total of 844 subjects diagnosed BD with an illness of 2 years' duration and minimum of two lifetime episodes and in clinical remission were evaluated for residual symptoms using Hamilton Depression Rating Scale (HAM-D) and Young Mania Rating Scale (YMRS). Based on the severity of residual symptoms, the study groups were divided into four groups. Results: Sixty-nine percent of the subjects had residual depressive symptoms (i.e., HAM-D score in the range of 1-7) and 59% had residual manic symptoms (i.e., YMRS score in the range of 1-7). The most common residual depressive symptom was psychic anxiety (34%) followed by impaired insight (29%). The most common manic symptom was poor insight (31%) followed by sleep disturbances (25%). Subjects with both sets of residual symptoms had onset of BD at a relatively young age, when compared to those with only residual depressive symptoms. Presence of any comorbid physical illness and substance abuse disorder was significantly higher in those with both sets of residual symptoms. Conclusions: The present study suggests that a substantial proportion of patients with BD have residual symptoms of both types. Comorbid physical illness and substance use were associated with residual symptoms. Identification and management of residual symptoms are highly essential to improve the overall outcome of patients with BD.
C1 [Grover, Sandeep; Chakrabarti, Subho; Sahoo, Swapnajeet] Postgrad Inst Med Educ & Res, Dept Psychiat, Chandigarh 160012, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh
RP Grover, S (corresponding author), Postgrad Inst Med Educ & Res, Dept Psychiat, Chandigarh 160012, India.
EM drsandeepg2002@yahoo.com
RI Grover, Sandeep/U-5297-2019; SAHOO, SWAPNAJEET/AAZ-5445-2020
OI chakrabarti, subho/0000-0001-6023-2194; Grover,
   Sandeep/0000-0002-2714-2055
CR Altshuler LL, 2006, J CLIN PSYCHIAT, V67, P1551, DOI 10.4088/JCP.v67n1009
   Angst J, 2000, BIOL PSYCHIAT, V48, P445, DOI 10.1016/S0006-3223(00)00909-4
   Baldassano CF, 2006, J CLIN PSYCHIAT, V67, P8
   BANOV MD, 1994, J CLIN PSYCHIAT, V55, P295
   Belzeaux R, 2013, J AFFECT DISORDERS, V151, P1009, DOI 10.1016/j.jad.2013.08.028
   Benazzi F, 2002, AM J PSYCHIAT, V159, P882, DOI 10.1176/appi.ajp.159.5.882
   Benazzi F, 2001, PSYCHOTHER PSYCHOSOM, V70, P232, DOI 10.1159/000056260
   Bonnín CM, 2010, J AFFECT DISORDERS, V121, P156, DOI 10.1016/j.jad.2009.05.014
   Calabrese JR, 1996, AM J PSYCHIAT, V153, P759
   Chang JS, 2006, J CLIN PSYCHIAT, V67, P461, DOI 10.4088/JCP.v67n0318
   Chengappa KNR, 2003, BIPOLAR DISORD, V5, P1, DOI 10.1034/j.1399-5618.2003.02237.x
   Cretu JB, 2016, J AFFECT DISORDERS, V190, P162, DOI 10.1016/j.jad.2015.09.076
   Freeman MP, 1998, AM J PSYCHIAT, V155, P12, DOI 10.1176/ajp.155.1.12
   Gitlin M, 2006, MOL PSYCHIATR, V11, P227, DOI 10.1038/sj.mp.4001793
   Gitlin MJ, 2011, J CLIN PSYCHIAT, V72, P692, DOI 10.4088/JCP.09m05291gre
   GITLIN MJ, 1995, AM J PSYCHIAT, V152, P1635
   Goldberg JF, 2007, AM J PSYCHIAT, V164, P1348, DOI 10.1176/appi.ajp.2007.05122032
   Grover S, 2014, NORD J PSYCHIAT, V68, P72, DOI 10.3109/08039488.2012.754052
   Gruber J, 2009, J AFFECT DISORDERS, V114, P41, DOI 10.1016/j.jad.2008.06.028
   Gutiérrez-Rojas L, 2011, PSYCHIAT RES, V186, P254, DOI 10.1016/j.psychres.2010.06.020
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Judd LL, 2005, ARCH GEN PSYCHIAT, V62, P1322, DOI 10.1001/archpsyc.62.12.1322
   Judd LL, 2003, ARCH GEN PSYCHIAT, V60, P261, DOI 10.1001/archpsyc.60.3.261
   Kaya E, 2007, PROG NEURO-PSYCHOPH, V31, P1387, DOI 10.1016/j.pnpbp.2007.06.003
   Keitner GI, 1996, COMPR PSYCHIAT, V37, P362, DOI 10.1016/S0010-440X(96)90018-8
   Krishnan KRR, 2005, PSYCHOSOM MED, V67, P1, DOI 10.1097/01.psy.0000151489.36347.18
   Lorenzo-Luaces L, 2018, J AFFECT DISORDERS, V227, P379, DOI 10.1016/j.jad.2017.11.028
   Malhotra N, 2013, J AFFECT DISORDERS, V150, P653, DOI 10.1016/j.jad.2013.03.010
   Marangell LB, 2009, J AFFECT DISORDERS, V114, P58, DOI 10.1016/j.jad.2008.07.006
   Marangell LB, 2004, J CLIN PSYCHIAT, V65, P24
   Mazza M, 2009, J AFFECT DISORDERS, V115, P27, DOI 10.1016/j.jad.2008.08.019
   Meyer B, 2006, EVID-BASED MENT HEAL, V9, P84, DOI 10.1136/ebmh.9.3.84
   Mittal VA, 2011, PSYCHIAT RES, V189, P158, DOI 10.1016/j.psychres.2011.06.006
   Murru A, 2018, EUR ARCH PSY CLIN N, V268, P749, DOI 10.1007/s00406-017-0811-0
   Muti M, 2011, EUR PSYCHIAT, V26
   Neogi R, 2016, WORLD J PSYCHIATR, V6, P431, DOI 10.5498/wjp.v6.i4.431
   Nierenberg AA, 1999, J CLIN PSYCHIAT, V60, P221, DOI 10.4088/JCP.v60n0403
   Perlis RH, 2006, AM J PSYCHIAT, V163, P217, DOI 10.1176/appi.ajp.163.2.217
   Perlis RH, 2009, BIPOLAR DISORD, V11, P391, DOI 10.1111/j.1399-5618.2009.00686.x
   Peters A, 2014, PSYCHOL MED, V44, P3455, DOI 10.1017/S0033291714000804
   Poon SH, 2015, CURR NEUROPHARMACOL, V13, P592, DOI 10.2174/1570159X13666150630171954
   Ram Dushad, 2010, Indian J Psychiatry, V52, P367, DOI 10.4103/0019-5545.74314
   Reischies FM, 2002, NEUROPSYCHOBIOLOGY, V46, P22, DOI 10.1159/000068020
   Rosa AR, 2009, BIPOLAR DISORD, V11, P401, DOI 10.1111/j.1399-5618.2009.00698.x
   ROYBYRNE P, 1985, ACTA PSYCHIAT SCAND, V71, P1, DOI 10.1111/j.1600-0447.1985.tb10510.x
   Samalin L, 2016, ACTA PSYCHIAT SCAND, V134, P57, DOI 10.1111/acps.12568
   Samalin L, 2017, J AFFECT DISORDERS, V210, P280, DOI 10.1016/j.jad.2016.12.054
   Samalin L, 2016, BIPOLAR DISORD, V18, P164, DOI 10.1111/bdi.12376
   Samalin L, 2014, J AFFECT DISORDERS, V159, P94, DOI 10.1016/j.jad.2014.02.023
   Serafini G, 2018, EUR ARCH PSY CLIN N, V268, P757, DOI 10.1007/s00406-018-0875-5
   Sheehan DV, 1998, J CLIN PSYCHIAT, V59, P22, DOI 10.4088/JCP.09m05305whi
   Suppes T, 1999, AM J PSYCHIAT, V156, P1164
   Sylvia LG, 2012, J PSYCHOPHARMACOL, V26, P1108, DOI 10.1177/0269881111421973
   Tohen M, 2003, AM J PSYCHIAT, V160, P2099, DOI 10.1176/appi.ajp.160.12.2099
   Tohen M, 2009, BIPOLAR DISORD, V11, P453, DOI 10.1111/j.1399-5618.2009.00726.x
   Vieta E, 2008, J AFFECT DISORDERS, V107, P169, DOI 10.1016/j.jad.2007.08.007
   WEHR TA, 1987, AM J PSYCHIAT, V144, P201
   Yon L, 2012, INT CLIN PSYCHOPHARM, V28, pe56
   YOUNG RC, 1978, BRIT J PSYCHIAT, V133, P429, DOI 10.1192/bjp.133.5.429
   ZARATE CA, 1995, J CLIN PSYCHIAT, V56, P108
   Zimmerman M, 2004, INT CLIN PSYCHOPHARM, V19, P1, DOI 10.1097/00004850-200401000-00001
NR 61
TC 14
Z9 14
U1 0
U2 1
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 0019-5545
EI 1998-3794
J9 INDIAN J PSYCHIAT
JI Indian J. Psychiatry
PD MAY-JUN
PY 2020
VL 62
IS 3
BP 295
EP 305
DI 10.4103/psychiatry.IndianJPsychiatry_760_19
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA LT7TA
UT WOS:000537267800011
PM 32773873
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Raue, S
   Wedekind, D
   Wiltfang, J
   Schmidt, U
AF Raue, Stefan
   Wedekind, Dirk
   Wiltfang, Jens
   Schmidt, Ulrike
TI The Role of Proopiomelanocortin and α-Melanocyte-Stimulating Hormone in
   the Metabolic Syndrome in Psychiatric Disorders: A Narrative Mini-Review
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE posttraumatic stress disorder; schizophrenia; metabolic syndrome; HPA
   axis; proopiomelanocortin (POMC); PTSD; melanocyte stimulating hormone
   (MSH)
ID POSTTRAUMATIC-STRESS-DISORDER; MAJOR DEPRESSIVE DISORDER; INDUCED
   WEIGHT-GAIN; PHYSICAL ILLNESS; BIPOLAR DISORDER; SCHIZOPHRENIA; OBESITY;
   PREVALENCE; RECEPTOR; OVERWEIGHT
AB The metabolic syndrome (MetS) comprises abdominal obesity, preclinical or full diabetes type 2, arterial hypertension, and dyslipidemia and affects a significant proportion of the general population with a remarkably higher prevalence in patients suffering from psychiatric disorders. However, studies exploring the pathogenetic link between MetS and psychiatric diseases are rare. Here, we aim to narrow this gap in knowledge by providing a narrative review on this topic that focuses on two psychiatric diseases, namely on schizophrenia and posttraumatic stress disorder (PTSD) since we assume them to be associated with two different main causalities of MetS: in schizophrenia, MetS evidently develops or aggravates in response to antipsychotic drug treatment while it assumingly develops in response to stress-induced endocrine and/or epigenetic alterations in PTSD. First, we compared the prevalences of MetS and associated pathologies (which we took from the latest meta-analyses) among different psychiatric disorders and were surprised that the prevalences of arterial hypertension and hyperglycemia in PTSD almost doubles those of the other psychiatric disorders. Next, we performed a literature search on the neurobiology of MetS and found numerous articles describing a role for proopiomelanocortin (POMC) in MetS. Thus, we concentrated further analysis on POMC and one of its downstream effector hormones, alpha-melanocyte-stimulating hormone (alpha-MSH). We found some evidence for a role of POMC in both PTSD and schizophrenia, in particular in antipsychotic-induced MetS, as well as for alpha-MSH in schizophrenia, but, surprisingly, no study on alpha-MSH in PTSD. Taken together, our synopsis reveals, first, a potential interaction between the POMC system and stress in the assumingly at least partially shared pathogenesis of psychiatric disorders and MetS, second, that modulation of the POMC system, in particular of the melanocortin 3 and 4 receptors, might be a promising target for the treatment of MetS and, third, that the DNA methylation status of POMC might speculatively be a promising biomarker for MetS in general and, possibly, in particular in the context of stress-related psychiatric conditions such as PTSD. To best of our knowledge, this is the first review on the role of the POMC system in MetS in psychiatric disorders.
C1 [Raue, Stefan; Schmidt, Ulrike] Univ Med Ctr Gottingen UMG, Psychotrauma Treatment Unit, Gottingen, Germany.
   [Raue, Stefan; Schmidt, Ulrike] Univ Med Ctr Gottingen UMG, RG Stress Modulat Neurodegenerat, Dept Psychiat & Psychotherapy, Gottingen, Germany.
   [Wedekind, Dirk; Wiltfang, Jens] Georg August Univ Univ, Med Ctr Gottingen, Dept Psychiat & Psychotherapy, Gottingen, Germany.
   [Wiltfang, Jens] German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany.
   [Wiltfang, Jens] Univ Aveiro, Dept Med Sci, IBiMED, Aveiro, Portugal.
   [Schmidt, Ulrike] Maastricht Univ, Med Ctr, Dept Psychiat & Neuropsychol, Sch Mental Hlth & Neurosci MHeNs, Maastricht, Netherlands.
C3 Helmholtz Association; German Center for Neurodegenerative Diseases
   (DZNE); Universidade de Aveiro; Maastricht University
RP Schmidt, U (corresponding author), Univ Med Ctr Gottingen UMG, Psychotrauma Treatment Unit, Gottingen, Germany.; Schmidt, U (corresponding author), Univ Med Ctr Gottingen UMG, RG Stress Modulat Neurodegenerat, Dept Psychiat & Psychotherapy, Gottingen, Germany.; Schmidt, U (corresponding author), Maastricht Univ, Med Ctr, Dept Psychiat & Neuropsychol, Sch Mental Hlth & Neurosci MHeNs, Maastricht, Netherlands.
EM ulrike.schmidt@med.uni-goettingen.de
RI Schmidt, Ulrike/KXQ-6095-2024
OI Wiltfang, Jens/0000-0003-1492-5330
FU Open Access Publication Funds of the Gottingen University
FX We acknowledge support by the Open Access Publication Funds of the
   Gottingen University.
CR Ak M, 2013, PSYCHONEUROENDOCRINO, V38, P341, DOI 10.1016/j.psyneuen.2012.06.012
   Allison DB, 1999, AM J PSYCHIAT, V156, P1686
   Amare AT, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/tp.2016.261
   American Psychiatric Association, 2013, DIAGN STAT MAN MENT, V5th, P947
   Asaad T, 2017, MIDDLE E CURR PSYCHI, V24, P93, DOI [10.1097/01.XME.0000516722.23761.98, DOI 10.1097/01.XME.0000516722.23761.98]
   Bak M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094112
   Bakirtzi G, 2015, THESIS
   Berglund ED, 2013, J CLIN INVEST, V123, P5061, DOI 10.1172/JCI70338
   Berthoud HR, 2008, ANNU REV PSYCHOL, V59, P55, DOI 10.1146/annurev.psych.59.103006.093551
   Björntorp P, 2000, NUTRITION, V16, P924, DOI 10.1016/S0899-9007(00)00422-6
   Carroll D, 2009, BIOL PSYCHIAT, V66, P91, DOI 10.1016/j.biopsych.2009.02.020
   Chilcoat HD, 1998, ADDICT BEHAV, V23, P827, DOI 10.1016/S0306-4603(98)00069-0
   Cohrs S, 2006, PSYCHOPHARMACOLOGY, V185, P11, DOI 10.1007/s00213-005-0279-x
   Craft S, 2009, ARCH NEUROL-CHICAGO, V66, P300, DOI 10.1001/archneurol.2009.27
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P138
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   del Campo A, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00144
   Duncan AE, 2015, CHILD ABUSE NEGLECT, V45, P154, DOI 10.1016/j.chiabu.2015.02.007
   Ehrlich S, 2010, J PSYCHIATR RES, V44, P827, DOI 10.1016/j.jpsychires.2010.01.011
   Engin A, 2017, ADV EXP MED BIOL, V960, P1, DOI 10.1007/978-3-319-48382-5_1
   Fani L, 2014, INT J OBESITY, V38, P163, DOI 10.1038/ijo.2013.80
   Foster-Schubert KE, 2006, ENDOCR REV, V27, P779, DOI 10.1210/er.2006-0041
   Freyberg Z, 2017, FRONT NEUROSCI-SWITZ, V11, DOI 10.3389/fnins.2017.00432
   Fries GR, 2016, CURR MOL PHARMACOL, V9, P126, DOI 10.2174/1874467208666150519114435
   Frodl T, 2013, NEUROBIOL DIS, V52, P24, DOI 10.1016/j.nbd.2012.03.012
   Geoffroy PA, 2015, CURR PHARM DESIGN, V21, P3352, DOI 10.2174/1381612821666150619093448
   Greenberg MS, 2014, ALZHEIMERS DEMENT, V10, pS155, DOI 10.1016/j.jalz.2014.04.008
   Haddad PM, 2014, PATIENT-RELAT OUTCOM, V5, P43, DOI 10.2147/PROM.S42735
   Hecker T, 2016, DEV PSYCHOPATHOL, V28, P1401, DOI 10.1017/S0954579415001248
   Himmerich H, 2015, ENDOCR METAB IMMUNE, V15, P252, DOI 10.2174/1871530315666150623092031
   Holtzman CW, 2013, NEUROSCIENCE, V249, P172, DOI 10.1016/j.neuroscience.2012.12.017
   Hummer M, 1995, EUR NEUROPSYCHOPHARM, V5, P437, DOI 10.1016/0924-977X(95)00012-E
   Jensen MD, 2014, J AM COLL CARDIOL, V63, P2985, DOI 10.1016/j.jacc.2013.11.004
   Katzmarzyk PT, 2005, DIABETES CARE, V28, P391, DOI 10.2337/diacare.28.2.391
   Kesebir Sermin, 2018, J Clin Med Res, V10, P453, DOI 10.14740/jocmr3389w
   Kring SII, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006696
   Kucerova J, 2015, BIOMED PAP, V159, P208, DOI 10.5507/bp.2014.060
   Kusumi I, 2015, PSYCHIAT CLIN NEUROS, V69, P243, DOI 10.1111/pcn.12242
   Labad J, 2019, PSYCHONEUROENDOCRINO, V102, P24, DOI 10.1016/j.psyneuen.2018.11.028
   Labad J, 2018, PSYCHIAT RES, V265, P284, DOI 10.1016/j.psychres.2018.05.018
   Lamberti JS, 2006, AM J PSYCHIAT, V163, P1273, DOI 10.1176/appi.ajp.163.7.1273
   Lett TAP, 2012, MOL PSYCHIATR, V17, P242, DOI 10.1038/mp.2011.109
   Li JW, 2017, NAT BIOMED ENG, V1, DOI 10.1038/s41551-017-0082
   Lian JM, 2015, PHARMACOL RES, V95-96, P20, DOI 10.1016/j.phrs.2015.03.004
   Lian JM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0104160
   Lindenmayer JP, 2003, AM J PSYCHIAT, V160, P290, DOI 10.1176/appi.ajp.160.2.290
   Liu J, 2013, INT J NEUROPSYCHOPH, V16, P105, DOI 10.1017/S146114571100174X
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Malan-Müller S, 2016, SCHIZOPHR RES, V170, P1, DOI 10.1016/j.schres.2015.11.011
   Mercer AJ, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00019
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P295, DOI 10.1093/schbul/sbs082
   Moleres A, 2013, FASEB J, V27, P2504, DOI 10.1096/fj.12-215566
   Monte AS, 2017, BEHAV BRAIN RES, V331, P30, DOI 10.1016/j.bbr.2017.04.057
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   Moraitis AG, 2017, J STEROID BIOCHEM, V165, P114, DOI 10.1016/j.jsbmb.2016.03.023
   Neredumilli P, 2014, ARCH MENT HLTH, V15, P245, DOI [10.1155/2012/572848, DOI 10.1155/2012/572848]
   Nguyen LT, 2017, J MOL ENDOCRINOL, V59, P81, DOI 10.1530/JME-17-0056
   Palasz A, 2016, PHARMACOL REP, V68, P292, DOI 10.1016/j.pharep.2015.09.012
   Panariello F, 2012, J OBES, V2012, DOI 10.1155/2012/572848
   Pariante CM, 2003, J NEUROENDOCRINOL, V15, P811
   Patel Krishna R, 2014, P T, V39, P638
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   de Melo LGP, 2017, PROG NEURO-PSYCHOPH, V78, P34, DOI 10.1016/j.pnpbp.2017.04.027
   Plagemann A, 2009, J PHYSIOL-LONDON, V587, P4963, DOI 10.1113/jphysiol.2009.176156
   Qi XL, 2015, ADDICT BIOL, V20, P324, DOI 10.1111/adb.12129
   Roseberry AG, 2015, NEUROSCI BIOBEHAV R, V56, P15, DOI 10.1016/j.neubiorev.2015.06.020
   Rosenbaum S, 2015, METABOLISM, V64, P926, DOI [10.1016/j.metabol.2015.04.009, 10.1016/j.metabol.2015.01.016]
   Scott KA, 2012, CURR OBES REP, V1, DOI 10.1007/s13679-011-0006-3
   Serova LI, 2013, BEHAV BRAIN RES, V250, P139, DOI 10.1016/j.bbr.2013.05.006
   Shams TA, 2014, CURR PSYCHIAT REP, V16, DOI 10.1007/s11920-014-0473-9
   Simsek S, 2017, ASIA-PAC PSYCHIAT, V9, DOI 10.1111/appy.12264
   Suliman S, 2016, HARVARD REV PSYCHIAT, V24, P271, DOI 10.1097/HRP.0000000000000106
   Tagami K, 2016, NEUROPEPTIDES, V58, P93, DOI 10.1016/j.npep.2015.12.010
   Toda C, 2017, ANNU REV PHYSIOL, V79, P209, DOI 10.1146/annurev-physiol-022516-034110
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vancampfort D, 2016, ALCOHOL ALCOHOLISM, V51, P515, DOI 10.1093/alcalc/agw040
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vancampfort D, 2013, AM J PSYCHIAT, V170, P265, DOI 10.1176/appi.ajp.2012.12050620
   Wakabayashi I, 2014, ALCOHOL CLIN EXP RES, V38, P1689, DOI 10.1111/acer.12425
   Weissberger GH, 2018, NEUROSCI BIOBEHAV R, V94, P49, DOI 10.1016/j.neubiorev.2018.08.009
   Wichmann S, 2017, PSYCHONEUROENDOCRINO, V83, P135, DOI 10.1016/j.psyneuen.2017.06.005
   Zaba M, 2015, PSYCHONEUROENDOCRINO, V55, P102, DOI 10.1016/j.psyneuen.2015.02.005
   Zhang JP, 2016, SCHIZOPHRENIA BULL, V42, P1418, DOI 10.1093/schbul/sbw058
NR 84
TC 11
Z9 11
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD NOV 14
PY 2019
VL 10
AR 834
DI 10.3389/fpsyt.2019.00834
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA JR2KR
UT WOS:000499461000001
PM 31798479
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bivanco-Lima, D
   Santos, ID
   Wang, YP
   Viana, MC
   Andrade, LH
   Lotufo, PA
   Benseñor, IJM
AF Bivanco-Lima, Danielle
   Santos, Itamar de Souza
   Wang, Yuan-Pang
   Viana, Maria Carmen
   Andrade, Laura Helena
   Lotufo, Paulo Andrade
   Bensenor, Isabela Judith Martins
TI Cardiovascular risk factors and major depressive disorder: a
   cross-sectional study in Sao Paulo, Brazil
SO SAO PAULO MEDICAL JOURNAL
LA English
DT Article
DE Depression; Risk factors; Cardiovascular diseases; Depressive disorder,
   major; Depressive disorders; Cardiovascular risk; Major depressive
   disorder; Depressed individuals; Lifestyle and risk factors
ID METABOLIC SYNDROME; HEALTH-SURVEY; SYMPTOMS; DISEASE; ASSOCIATION;
   OBESITY; METAANALYSIS; INDIVIDUALS; MORTALITY; SYNDEMICS
AB BACKGROUND: Cardiovascular risk factors can mediate the association between depression and cardiovascular diseases.
   OBJECTIVE: To evaluate cardiovascular risk factors in adult individuals with and without histories of major depression in the metropolitan region of Sao Paulo, Brazil.
   DESIGN AND SETTING: Cross-sectional study in Sao Paulo (SP), Brazil.
   METHODS: This study evaluated 423 individuals without any lifetime diagnosis of major depression and 203 individuals with a previous diagnosis of major depression (n = 626). The participants underwent a psychiatric evaluation using a structured clinical interview (SCID-1), an anthropometric evaluation and a clinical evaluation that included blood pressure measurement and assessment of fasting blood glucose, lipid profile and physical activity levels.
   RESULTS: Individuals with histories of major depression were more likely to be female (P < 0.0001). Individuals with lifetime diagnoses of major depression were more likely to be current smokers (odds ratio, OR 1.61; 95% confidence interval, CI 1.01-2.59) and to have diabetes (OR 1.79; 95% CI 1.01-3.21); and less likely to be obese (OR 0.58; 95% CI 0.35-0.94).
   CONCLUSION: Individuals with major depression had higher odds of presenting tobacco smoking and diabetes, and lower odds of being obese. Healthcare professionals need to be aware of this, so as to increase the rates of diagnosis and treatment in this population.
C1 [Bivanco-Lima, Danielle; Santos, Itamar de Souza; Wang, Yuan-Pang; Viana, Maria Carmen; Andrade, Laura Helena; Lotufo, Paulo Andrade; Bensenor, Isabela Judith Martins] Univ Sao Paulo, Sect Psychiat Epidemiol LIM 23, Inst Psychiat, Fac Med FMUSP, Sao Paulo, SP, Brazil.
   [Bivanco-Lima, Danielle] Fac Ciencias Med Santa Casa Sao Paulo FCMSP, Dept Publ Hlth, Sao Paulo, SP, Brazil.
   [Santos, Itamar de Souza; Lotufo, Paulo Andrade; Bensenor, Isabela Judith Martins] Univ Sao Paulo, Hosp Univ HU, Ctr Clin & Epidemiol Res, Sao Paulo, SP, Brazil.
   [Santos, Itamar de Souza; Lotufo, Paulo Andrade; Bensenor, Isabela Judith Martins] Univ Sao Paulo, Dept Internal Med, Fac Med FMUSP, Sao Paulo, SP, Brazil.
   [Wang, Yuan-Pang; Andrade, Laura Helena] Univ Sao Paulo, Sect Psychiat Epidemiol LIM 23, Inst Psychiat, Hosp Clin FMUSP,Fac Med, Sao Paulo, SP, Brazil.
   [Viana, Maria Carmen] Univ Fed Espirito Santo UFES, Postgrad Program Collect Hlth, Vitoria, ES, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade de
   Sao Paulo; Universidade de Sao Paulo; Universidade Federal do Espirito
   Santo
RP Bivanco-Lima, D (corresponding author), R Doutor Cesario Mota Jr 61,5 Andar,Sala 03, BR-01221020 Sao Paulo, SP, Brazil.
EM danielle.bivanco@gmail.com
RI Bensenor, Isabela/L-3306-2017; Andrade, Laura Helena/F-3023-2010; Wang,
   Yuan-Pang/A-4863-2008; Santos, Itamar/K-7055-2012; Lotufo,
   Paulo/A-9843-2008
OI Bivanco-Lima, Danielle/0000-0001-9243-0232; Andrade, Laura
   Helena/0000-0002-2362-3521; Wang, Yuan-Pang/0000-0001-7076-8312;
   Bensenor, Isabela/0000-0002-6723-5678; Santos,
   Itamar/0000-0003-3212-8466; Lotufo, Paulo/0000-0002-4856-8450
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (Sao Paulo Research
   Foundation) [FAPESP 03/00204-3]; Fundo de Apoio a Ciencia e Tecnologia
   de Vitoria (FACITEC, Vitoria [Municipal] Fund for the of Science and
   Technology) [002/2003]; Conselho Nacional de Desenvolvimento Cientifico
   e Tecnologico (Brazilian National Council for Scientific and
   Technological Development) [CNPq 307933/2019-9]; United States National
   Institutes of Mental Health [R01-MH070884]; MacArthur Foundation; Pfizer
   Foundation; United States Public Health Service [R13-MH066849,
   R01-MH069864, R01-DA016558]; Fogarty International Center [FIRCA
   R03-TW006481]; Pan-American Health Organization; Eli Lilly and Company
   Foundation; Ortho-McNeil Pharmaceutical; GlaxoSmithKline; Bristol-Myers
   Squibb and Shire; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
   (FAPESP) [03/00204-3] Funding Source: FAPESP
FX The Sao Paulo Megacity Mental Health Survey was funded by the Fundacao
   de Amparo a Pesquisa do Estado de Sao Paulo (Sao Paulo Research
   Foundation; FAPESP 03/00204-3), and Fundo de Apoio a Ciencia e
   Tecnologia de Vitoria (FACITEC, Vitoria [Municipal] Fund for the Support
   of Science and Technology; 002/2003 for instrument development). The
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (Brazilian
   National Council for Scientific and Technological Development; CNPq
   307933/2019-9) supported Dr. L. H. Andrade. The Sao Paulo Megacity
   Mental Health Survey was conducted in conjunction with the World Health
   Organization World Mental Health Survey Initiative. The main
   coordination center activities at Harvard University were supported by
   the United States National Institutes of Mental Health (R01-MH070884),
   John D. and Catherine T. MacArthur Foundation, Pfizer Foundation and
   United States Public Health Service (R13-MH066849, R01-MH069864 and
   R01-DA016558), as well as by the Fogarty International Center (FIRCA
   R03-TW006481), Pan-American Health Organization, Eli Lilly and Company
   Foundation, Ortho-McNeil Pharmaceutical, GlaxoSmithKline, Bristol-Myers
   Squibb and Shire. A complete list of the World Mental Health
   publications can be found at http://www.hcp.med.harvard.edu/wmh/.None of
   the sponsors had any role in the design, analysis, interpretation of
   results or preparation of this paper
CR Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
   Andersohn F, 2009, AM J PSYCHIAT, V166, P591, DOI 10.1176/appi.ajp.2008.08071065
   Appleton KM, 2013, J AFFECT DISORDERS, V151, P632, DOI 10.1016/j.jad.2013.07.010
   Bivanco-Lima D, 2013, REV ASSOC MED BRAS, V59, P298, DOI 10.1016/j.ramb.2012.12.006
   Bonnet F, 2005, ATHEROSCLEROSIS, V178, P339, DOI 10.1016/j.atherosclerosis.2004.08.035
   Borcoi AR, 2020, J PSYCHIATR RES, V121, P24, DOI 10.1016/j.jpsychires.2019.10.011
   Centers for Disease Control and Prevention (CDC). National Center for Health Statistics (NCHS), 2004, NATL HLTH NUTR EXAMI
   Chang CK, 2010, BMC PSYCHIATRY, V10, DOI 10.1186/1471-244X-10-77
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   Cuijpers P, 2019, CURR PSYCHIAT REP, V21, DOI 10.1007/s11920-019-1117-x
   Diderichsen F, 2019, SSM-POPUL HLTH, V7, DOI 10.1016/j.ssmph.2018.11.002
   Dinas PC, 2011, IRISH J MED SCI, V180, P319, DOI 10.1007/s11845-010-0633-9
   FerroLuzzi A, 1995, WHO TECH REP SER, V854, P1
   First MB., 2002, STRUCTURED CLIN INTE
   Gomes AP, 2019, REV SAUDE PUBL, V53, DOI [10.11606/S1518-8787.2019053001119, 10.11606/s1518-8787.2019053001119]
   Pitanga FJG, 2018, ARQ BRAS CARDIOL, V110, P36, DOI 10.5935/abc.20170178
   Goodwin RD, 2017, DRUG ALCOHOL DEPEN, V173, P191, DOI 10.1016/j.drugalcdep.2016.11.038
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Jacka FN, 2007, PSYCHOSOMATICS, V48, P54, DOI 10.1176/appi.psy.48.1.54
   Knol MJ, 2006, DIABETOLOGIA, V49, P837, DOI 10.1007/s00125-006-0159-x
   Konttinen H, 2010, AM J CLIN NUTR, V92, P1031, DOI 10.3945/ajcn.2010.29732
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178, DOI 10.4088/JCP.v69n0202
   Lawrence D, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-285
   Lin EHB, 2008, J PSYCHOSOM RES, V65, P571, DOI 10.1016/j.jpsychores.2008.06.007
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Matsudo S., 2001, REV BRASILEIRA ATIVI, V6, P5
   Mendenhall E, 2017, LANCET, V389, P951, DOI 10.1016/S0140-6736(17)30402-6
   Mendenhall E, 2016, MED ANTHROPOL Q, V30, P462, DOI 10.1111/maq.12215
   Mendenhall E, 2014, DIABETES RES CLIN PR, V103, P276, DOI 10.1016/j.diabres.2014.01.001
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Mommersteeg PMC, 2013, DIABETIC MED, V30, pE208, DOI 10.1111/dme.12193
   Moulton CD, 2015, LANCET DIABETES ENDO, V3, P461, DOI 10.1016/S2213-8587(15)00134-5
   Nicholson A, 2006, EUR HEART J, V27, P2763, DOI 10.1093/eurheartj/ehl338
   Paulitsch RG, 2021, J HEALTH PSYCHOL, V26, P2020, DOI 10.1177/1359105319897778
   Qin TT, 2017, SCI REP-UK, V7, DOI 10.1038/srep39940
   Roth GA, 2018, LANCET, V392, P1736, DOI 10.1016/S0140-6736(18)32203-7
   Roy T, 2012, J AFFECT DISORDERS, V142, pS8, DOI 10.1016/S0165-0327(12)70004-6
   Seo Y, 2018, PSYCHIAT RES, V263, P88, DOI 10.1016/j.psychres.2018.02.052
   Simon GE, 2006, ARCH GEN PSYCHIAT, V63, P824, DOI 10.1001/archpsyc.63.7.824
   Strine TW, 2008, GEN HOSP PSYCHIAT, V30, P127, DOI 10.1016/j.genhosppsych.2007.12.008
   Timonen M, 2006, MOL PSYCHIATR, V11, P929, DOI 10.1038/sj.mp.4001838
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Viana MC, 2009, REV BRAS PSIQUIATR, V31, P375, DOI 10.1590/S1516-44462009000400016
   Rocha SAV, 2019, J BRAS PNEUMOL, V45
   Weaver LJ, 2014, MED ANTHROPOL, V33, P92, DOI 10.1080/01459740.2013.808637
   Wiltink J, 2011, J AFFECT DISORDERS, V130, P429, DOI 10.1016/j.jad.2010.10.041
   World Health Organization, 2018, MENT HLTH PRIM CAR I
   Wulsin LR, 2003, PSYCHOSOM MED, V65, P201, DOI 10.1097/01.PSY.0000058371.50240.E3
NR 48
TC 2
Z9 2
U1 1
U2 4
PU ASSOCIACAO PAULISTA MEDICINA
PI SAO PAULO
PA AV BRIG LUIS ANTONIO, 278-7 ANDAR, SAO PAULO, CEP01318-901, BRAZIL
SN 1516-3180
J9 SAO PAULO MED J
JI Sao Paulo Med. J.
PD JUL-AUG
PY 2021
VL 139
IS 4
BP 364
EP 371
DI 10.1590/1516-3180.2020.0054.R1.1802021
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA TU5CJ
UT WOS:000681054100009
PM 34161521
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yuan, Q
   Zeng, ZL
   Yang, SQ
   Li, AQ
   Zu, XY
   Liu, JH
AF Yuan, Qing
   Zeng, Z. L.
   Yang, Shiqi
   Li, Anqi
   Zu, Xuyu
   Liu, Jianghua
TI Mitochondrial Stress in Metabolic Inflammation: Modest Benefits and Full
   Losses
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID TARGETED ANTIOXIDANT MITOQ; HIGH-FAT-DIET; ADIPOSE-TISSUE; CALORIC
   RESTRICTION; OXIDATIVE STRESS; INSULIN-RESISTANCE; SKELETAL-MUSCLE;
   COMPLEX-II; OBESITY; EXERCISE
AB Energy intake and metabolic balance are the pillars of health preservation. Overnutrition causes nonspecific, persistently low inflammatory state known as metabolic inflammation. This condition contributes to the pathophysiology of various metabolic disorders, such as atherosclerosis, obesity, diabetes mellitus, and metabolic syndrome. The mitochondria maintain the balance of energy metabolism. Excessive energy stress can lead to mitochondrial dysfunction, which promotes metabolic inflammation. The inflammatory environment further impairs mitochondrial function. Accordingly, excellent organism design keeps the body metabolically healthy in the context of mitochondrial dysfunction, and moderate mitochondrial stress can have a beneficial effect. This review summarises the research progress on the multifaceted characterisation of mitochondrial dysfunction and its role in metabolic inflammation.
C1 [Yuan, Qing; Zeng, Z. L.; Yang, Shiqi; Li, Anqi; Zu, Xuyu; Liu, Jianghua] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Metab & Endocrinol, Hengyang, Peoples R China.
   [Yuan, Qing; Zeng, Z. L.; Yang, Shiqi; Li, Anqi; Liu, Jianghua] Univ South China, Hengyang, Peoples R China.
C3 University of South China; University of South China
RP Zu, XY; Liu, JH (corresponding author), Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Metab & Endocrinol, Hengyang, Peoples R China.; Liu, JH (corresponding author), Univ South China, Hengyang, Peoples R China.
EM 1398169303@qq.com; zzl@usc.edu.cn; 784770822@qq.com; 315788889@qq.com;
   476969758@qq.com; jianghua990@126.com
RI Li, Anqi/GPT-2444-2022; qing, yuan/HPI-2135-2023; ZhaoLin,
   Zeng/W-8649-2018
OI ZhaoLin, Zeng/0000-0002-9479-3982; liu, jianghua/0000-0003-3010-5113
FU National Natural Science Foundation of China; Hunan Natural Science
   Foundation; Postgraduate Scientific Research Innovation Project of Hunan
   Province;  [82270939];  [2022JJ70036];  [CX20210917]
FX AcknowledgmentsThis work is supported by the National Natural Science
   Foundation of China (No. 82270939), Hunan Natural Science Foundation
   (2022JJ70036), and the Postgraduate Scientific Research Innovation
   Project of Hunan Province (CX20210917).
CR Alexopoulos SJ, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-16298-2
   Anderson AP, 2020, NUCLEIC ACIDS RES, V48, P817, DOI 10.1093/nar/gkz1018
   Archibald JM, 2015, CURR BIOL, V25, pR911, DOI 10.1016/j.cub.2015.07.055
   Asterholm IW, 2014, CELL METAB, V20, P103, DOI 10.1016/j.cmet.2014.05.005
   Axelrod CL, 2020, EMBO MOL MED, V12, DOI 10.15252/emmm.202012088
   Axelrod CL, 2019, ACTA PHYSIOL, V225, DOI 10.1111/apha.13216
   Bach D, 2005, DIABETES, V54, P2685, DOI 10.2337/diabetes.54.9.2685
   Bean C, 2021, NAT METAB, V3, P1633, DOI 10.1038/s42255-021-00497-2
   Bonekamp NA, 2020, NATURE, V588, P712, DOI 10.1038/s41586-020-03048-z
   Boutens L, 2018, DIABETOLOGIA, V61, P942, DOI 10.1007/s00125-017-4526-6
   Bravo-Sagua R, 2017, COMPR PHYSIOL, V7, P623, DOI 10.1002/cphy.c160013
   Brestoff JR, 2021, CELL METAB, V33, P270, DOI 10.1016/j.cmet.2020.11.008
   Cecchini G, 2003, ANNU REV BIOCHEM, V72, P77, DOI 10.1146/annurev.biochem.72.121801.161700
   Chakrabarti R, 2021, NATURE, V593, P346, DOI 10.1038/d41586-021-01173-x
   Chen SY, 2021, METABOLISM, V117, DOI 10.1016/j.metabol.2021.154724
   Cheng CF, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19113447
   Cienfuegos S, 2020, CELL METAB, V32, P366, DOI 10.1016/j.cmet.2020.06.018
   Davinelli S, 2020, TRENDS ENDOCRIN MET, V31, P536, DOI 10.1016/j.tem.2020.02.011
   de Marañón AM, 2021, ANTIOXID REDOX SIGN, V35, P377, DOI 10.1089/ars.2021.0019
   Penaforte FRD, 2019, PSYCHIAT RES, V271, P715, DOI 10.1016/j.psychres.2018.11.070
   Della Guardia L, 2021, CYTOKINE GROWTH F R, V62, P83, DOI 10.1016/j.cytogfr.2021.09.003
   Deretic V, 2021, IMMUNITY, V54, P437, DOI 10.1016/j.immuni.2021.01.018
   Diaz-Vegas A, 2020, ENDOCR REV, V41, P491, DOI 10.1210/endrev/bnaa005
   Dubé JJ, 2020, J CLIN ENDOCR METAB, V105, DOI 10.1210/clinem/dgz272
   Edwards R, 2020, BIOL CHEM, V401, P737, DOI 10.1515/hsz-2020-0114
   Escribano-Lopez I, 2016, REDOX BIOL, V10, P200, DOI 10.1016/j.redox.2016.10.017
   Esteban-Martínez L, 2018, AUTOPHAGY, V14, P915, DOI 10.1080/15548627.2017.1332567
   Fan MR, 2020, NATURE, V582, P129, DOI 10.1038/s41586-020-2309-6
   Fang WJ, 2018, ACTA PHARMACOL SIN, V39, P59, DOI 10.1038/aps.2017.50
   Fernandez-Vizarra E, 2021, FEBS LETT, V595, P1062, DOI 10.1002/1873-3468.13995
   Filiou MD, 2011, BIOL PSYCHIAT, V70, P1074, DOI 10.1016/j.biopsych.2011.06.009
   Finley LWS, 2012, P NATL ACAD SCI USA, V109, P2931, DOI 10.1073/pnas.1115813109
   Finocchietto P, 2022, PHARMACOL RES, V178, DOI 10.1016/j.phrs.2021.106028
   Fisher-Wellman KH, 2019, CELL REP, V26, P1557, DOI 10.1016/j.celrep.2019.01.057
   Fisher-Wellman KH, 2018, CELL REP, V24, P3593, DOI 10.1016/j.celrep.2018.08.091
   Flockhart M, 2021, CELL METAB, V33, P957, DOI 10.1016/j.cmet.2021.02.017
   Fonseca TB, 2019, NATURE, V570, pE34, DOI 10.1038/s41586-019-1296-y
   Foote K, 2018, AGING CELL, V17, DOI 10.1111/acel.12773
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gan L, 2018, TOXICOL APPL PHARM, V341, P1, DOI 10.1016/j.taap.2018.01.003
   Gao P, 2020, DIABETES, V69, P165, DOI 10.2337/db19-0526
   Gao S, 2021, TRENDS CELL BIOL, V31, P62, DOI 10.1016/j.tcb.2020.09.008
   Gebara E, 2021, BIOL PSYCHIAT, V89, P1033, DOI 10.1016/j.biopsych.2020.12.003
   Geng Y, 2020, BBA-MOL BASIS DIS, V1866, DOI 10.1016/j.bbadis.2019.165621
   Giacomello M, 2020, NAT REV MOL CELL BIO, V21, P204, DOI 10.1038/s41580-020-0210-7
   Gong LL, 2020, LIFE SCI, V242, DOI 10.1016/j.lfs.2019.117212
   Gupta A, 2021, BBA-BIOENERGETICS, V1862, DOI 10.1016/j.bbabio.2020.148323
   Habich M, 2019, BRIT J PHARMACOL, V176, P514, DOI 10.1111/bph.14480
   Heinonen S, 2015, DIABETES, V64, P3135, DOI 10.2337/db14-1937
   Heo JW, 2021, FASEB J, V35, DOI 10.1096/fj.202002394R
   Hofer SJ, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.717343
   Holowko J, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071461
   Honecker J, 2021, INT J OBESITY, V45, P2108, DOI 10.1038/s41366-021-00883-6
   Hoppins S, 2011, MOL CELL, V41, P150, DOI 10.1016/j.molcel.2010.11.030
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Houzelle A, 2021, DIABETOLOGIA, V64, P424, DOI 10.1007/s00125-020-05335-w
   Hu L, 2019, THERANOSTICS, V9, P3687, DOI 10.7150/thno.33684
   Huang T, 2021, SCI ADV, V7, DOI 10.1126/sciadv.abj0534
   Huang YJ, 2019, AGING-US, V11, P2217, DOI 10.18632/aging.101910
   Huangyang PW, 2020, CELL METAB, V31, P174, DOI 10.1016/j.cmet.2019.10.012
   Iverson TM, 2013, BBA-BIOENERGETICS, V1827, P648, DOI 10.1016/j.bbabio.2012.09.008
   Jian CS, 2020, CELL METAB, V31, P892, DOI 10.1016/j.cmet.2020.04.011
   Jiang HW, 2019, DIABETES, V68, P2197, DOI 10.2337/db19-0589
   Jiang Q, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/8837893
   Johnson J, 2022, AUTOPHAGY, V18, P465, DOI 10.1080/15548627.2021.2014769
   Jonckheere AI, 2012, J INHERIT METAB DIS, V35, P211, DOI 10.1007/s10545-011-9382-9
   Judge A, 2020, ESSAYS BIOCHEM, V64, P607, DOI 10.1042/EBC20190041
   Kadenbach B, 2015, MITOCHONDRION, V24, P64, DOI 10.1016/j.mito.2015.07.002
   Kanikowska D, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10071018
   Kato H, 2015, J PINEAL RES, V59, P267, DOI 10.1111/jpi.12259
   Kawanishi N, 2010, EXERC IMMUNOL REV, V16, P105
   Khalafi M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12040925
   Khoo WY, 2020, J NUTR BIOCHEM, V76, DOI 10.1016/j.jnutbio.2019.108262
   Kim HJ, 2012, BBA-MOL CELL RES, V1823, P1604, DOI 10.1016/j.bbamcr.2012.04.008
   Kleele T, 2021, NATURE, V593, P435, DOI 10.1038/s41586-021-03510-6
   Ko MS, 2021, AUTOPHAGY, V17, P1205, DOI 10.1080/15548627.2020.1753002
   Kraus F, 2021, NATURE, V590, P57, DOI 10.1038/s41586-021-03214-x
   Lanza IR, 2012, CELL METAB, V16, P777, DOI 10.1016/j.cmet.2012.11.003
   Lei P, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201800795
   Lennicke C, 2021, MOL CELL, V81, P3691, DOI 10.1016/j.molcel.2021.08.018
   Li C, 2020, FRONT CELL DEV BIOL, V8, DOI 10.3389/fcell.2020.00796
   Li YJ, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-12912-0
   Li Y, 2022, CELL DEATH DIS, V13, DOI 10.1038/s41419-021-04469-y
   Liu L, 2021, EMBO REP, V22, DOI 10.15252/embr.202050629
   Liu SS, 2021, CELL METAB, V33, P1974, DOI 10.1016/j.cmet.2021.06.013
   Liu Y, 2020, SIGNAL TRANSDUCT TAR, V5, DOI 10.1038/s41392-020-0155-5
   Liu Y, 2021, NAT CHEM BIOL, V17, P298, DOI 10.1038/s41589-020-00723-0
   Luo SY, 2018, P NATL ACAD SCI USA, V115, P13039, DOI 10.1073/pnas.1810946115
   Ma S, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/9286458
   Ma WQ, 2019, MOL CELL ENDOCRINOL, V479, P39, DOI 10.1016/j.mce.2018.08.012
   Mancini G, 2019, CELL REP, V26, P2849, DOI 10.1016/j.celrep.2019.02.039
   Maneechote C, 2019, CLIN SCI, V133, P2431, DOI 10.1042/CS20190960
   Marín-Royo G, 2019, FASEB J, V33, P12060, DOI 10.1096/fj.201900347RR
   Masand R, 2018, CELL METAB, V27, P616, DOI 10.1016/j.cmet.2018.01.018
   Mason SA, 2022, DIABETES OBES METAB, V24, P1047, DOI 10.1111/dom.14669
   Mehrabani S, 2020, J CACHEXIA SARCOPENI, V11, P1447, DOI 10.1002/jcsm.12611
   Mercer JR, 2012, FREE RADICAL BIO MED, V52, P841, DOI 10.1016/j.freeradbiomed.2011.11.026
   Miotto PM, 2018, DIABETES, V67, P2199, DOI 10.2337/db18-0417
   Morio B, 2021, CELL CALCIUM, V94, DOI 10.1016/j.ceca.2020.102336
   Mousavi SR, 2020, LAB ANIMAL, V49, P119, DOI 10.1038/s41684-020-0503-7
   Nicholls TJ, 2018, TRENDS BIOCHEM SCI, V43, P869, DOI 10.1016/j.tibs.2018.08.007
   Nishida Y, 2020, J CACHEXIA SARCOPENI, V11, P241, DOI 10.1002/jcsm.12530
   Nisr RB, 2019, CELL MOL LIFE SCI, V76, P4887, DOI 10.1007/s00018-019-03148-8
   Nuevo-Tapioles C, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-17384-1
   Onishi M, 2021, EMBO J, V40, DOI 10.15252/embj.2020104705
   Pardo R, 2019, FASEB J, V33, P2343, DOI 10.1096/fj.201800310R
   Pataky MW, 2021, CELL METAB, V33, P847, DOI 10.1016/j.cmet.2021.04.008
   Pereira RO, 2017, EMBO J, V36, P2126, DOI 10.15252/embj.201696179
   Pérez S, 2019, J PATHOL, V247, P48, DOI 10.1002/path.5166
   Perry RJ, 2018, CELL METAB, V27, P210, DOI 10.1016/j.cmet.2017.10.004
   Popov LD, 2020, J CELL MOL MED, V24, P4892, DOI 10.1111/jcmm.15194
   Protasoni M, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22020586
   Rafiei H, 2019, NUTRIENTS, V11, DOI 10.3390/nu11030541
   Reilly SM, 2017, NAT REV ENDOCRINOL, V13, P633, DOI 10.1038/nrendo.2017.90
   Ren T, 2017, ONCOGENE, V36, P5897, DOI 10.1038/onc.2017.167
   Rodriguez-Cuenca S, 2021, FASEB J, V35, DOI 10.1096/fj.202100262RR
   Rodriguez-Cuenca S, 2010, FREE RADICAL BIO MED, V48, P161, DOI 10.1016/j.freeradbiomed.2009.10.039
   Roh HT, 2017, J SPORT HEALTH SCI, V6, P447, DOI 10.1016/j.jshs.2016.07.006
   Rutter J, 2010, MITOCHONDRION, V10, P393, DOI 10.1016/j.mito.2010.03.001
   Saltiel AR, 2012, CELL METAB, V15, P798, DOI 10.1016/j.cmet.2012.03.001
   Shao D, 2020, CIRCULATION, V142, P983, DOI 10.1161/CIRCULATIONAHA.119.043319
   Sheldon RD, 2016, J HEPATOL, V64, P171, DOI 10.1016/j.jhep.2015.08.022
   Shimada S, 2017, EMBO J, V36, P291, DOI 10.15252/embj.201695021
   Shin SK, 2020, REDOX BIOL, V37, DOI 10.1016/j.redox.2020.101749
   Singh B, 2018, CELL DEATH DIS, V9, DOI 10.1038/s41419-018-0765-9
   Sliter DA, 2018, NATURE, V561, P258, DOI 10.1038/s41586-018-0448-9
   Sousa JS, 2018, SUBCELL BIOCHEM, V87, P167, DOI 10.1007/978-981-10-7757-9_7
   Spadaro O, 2022, SCIENCE, V375, P671, DOI 10.1126/science.abg7292
   Spinelli JB, 2021, SCIENCE, V374, P1227, DOI 10.1126/science.abi7495
   Teodoro BG, 2014, J PINEAL RES, V57, P155, DOI 10.1111/jpi.12157
   Tian Y, 2016, CELL, V165, P1197, DOI 10.1016/j.cell.2016.04.011
   Tomar D, 2019, CELL REP, V26, P3709, DOI 10.1016/j.celrep.2019.02.107
   Tong MM, 2019, CIRC RES, V124, P1360, DOI 10.1161/CIRCRESAHA.118.314607
   TRUMPOWER BL, 1990, J BIOL CHEM, V265, P11409
   Vernochet C, 2012, CELL METAB, V16, P765, DOI 10.1016/j.cmet.2012.10.016
   Vinothkumar KR, 2014, NATURE, V515, P80, DOI 10.1038/nature13686
   Wai T, 2016, TRENDS ENDOCRIN MET, V27, P105, DOI 10.1016/j.tem.2015.12.001
   Wall CE, 2015, P NATL ACAD SCI USA, V112, P8714, DOI 10.1073/pnas.1509930112
   Wang NN, 2017, LIFE SCI, V191, P122, DOI 10.1016/j.lfs.2017.08.023
   Wang QL, 2017, DIABETES, V66, P193, DOI 10.2337/db16-0915
   Weir HJ, 2017, CELL METAB, V26, P884, DOI 10.1016/j.cmet.2017.09.024
   Wensveen FM, 2015, EUR J IMMUNOL, V45, P2446, DOI 10.1002/eji.201545502
   Wright LE, 2017, AM J PHYSIOL-ENDOC M, V313, pE641, DOI 10.1152/ajpendo.00143.2016
   Wu LW, 2020, BRIT J PHARMACOL, V177, P3760, DOI 10.1111/bph.15099
   Xu DQ, 2020, ACTA PHARMACOL SIN, V41, P791, DOI 10.1038/s41401-019-0345-2
   Yamada Y, 2020, ADV DRUG DELIVER REV, V154, P187, DOI 10.1016/j.addr.2020.09.010
   Yan CJ, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8040379
   Yang J, 2021, CRIT REV FOOD SCI, V61, P3857, DOI 10.1080/10408398.2020.1809344
   Yin XL, 2016, HUM MOL GENET, V25, P1739, DOI 10.1093/hmg/ddw045
   Yoshikawa S, 2015, CHEM REV, V115, P1936, DOI 10.1021/cr500266a
   Yu LM, 2021, J PINEAL RES, V70, DOI 10.1111/jpi.12698
   Yu TZ, 2006, P NATL ACAD SCI USA, V103, P2653, DOI 10.1073/pnas.0511154103
   Yu WH, 2020, REDOX BIOL, V37, DOI 10.1016/j.redox.2020.101761
   Zeng Z, 2022, FRONT CARDIOVASC MED, V9, DOI 10.3389/fcvm.2022.879752
   Zeng ZL, 2020, EXP CELL RES, V393, DOI 10.1016/j.yexcr.2020.112108
   Zhao LL, 2020, CHEM RES TOXICOL, V33, P2491, DOI 10.1021/acs.chemrestox.0c00083
   Zhao M, 2021, THERANOSTICS, V11, P1845, DOI 10.7150/thno.50905
   Zhao M, 2021, ACS NANO, V15, P1519, DOI 10.1021/acsnano.0c08947
   Zhou B, 2018, J CLIN INVEST, V128, P3716, DOI 10.1172/JCI120849
   Zhou H, 2018, J PINEAL RES, V64, DOI 10.1111/jpi.12450
   Zhou RB, 2011, NATURE, V469, P221, DOI 10.1038/nature09663
   Zhu D, 2020, SCI ADV, V6, DOI 10.1126/sciadv.abb2529
   Zickermann V, 2008, J BIOENERG BIOMEMBR, V40, P475, DOI 10.1007/s10863-008-9171-9
NR 163
TC 17
Z9 18
U1 4
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD NOV 22
PY 2022
VL 2022
AR 8803404
DI 10.1155/2022/8803404
PG 17
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 6T0VA
UT WOS:000893400300001
PM 36457729
OA hybrid
DA 2025-06-11
ER

PT J
AU Frangou, S
   Shirali, M
   Adams, MJ
   Howard, DM
   Gibson, J
   Hall, LS
   Smith, BH
   Padmanabhan, S
   Murray, AD
   Porteous, DJ
   Haley, CS
   Deary, IJ
   Clarke, TK
   McIntosh, AM
AF Frangou, Sophia
   Shirali, Masoud
   Adams, Mark J.
   Howard, David M.
   Gibson, Jude
   Hall, Lynsey S.
   Smith, Blair H.
   Padmanabhan, Sandosh
   Murray, Alison D.
   Porteous, David J.
   Haley, Chris S.
   Deary, Ian J.
   Clarke, Toni-Kim
   McIntosh, Andrew M.
TI Insulin resistance: Genetic associations with depression and cognition
   in population based cohorts
SO EXPERIMENTAL NEUROLOGY
LA English
DT Article
DE Insulin resistance; Mendelian randomization; Polygenic risk scores;
   Genetic association; Depression; Cognition
ID METABOLIC SYNDROME; MENDELIAN RANDOMIZATION; DIABETES-MELLITUS;
   BIDIRECTIONAL ASSOCIATION; PROVISIONAL REPORT; PHYSICAL-ACTIVITY; VERBAL
   FLUENCY; LIFE-SPAN; RISK; GLUCOSE
AB Insulin resistance, broadly defined as the reduced ability of insulin to exert its biological action, has been associated with depression and cognitive dysfunction in observational studies. However, it is unclear whether these associations are causal and whether they might be underpinned by other shared factors. To address this knowledge gap, we capitalized on the stability of genetic biomarkers through the lifetime, and on their unidirectional relationship with depression and cognition. Specifically, we determined the association between quantitative measures of cognitive function and depression and genetic instruments of insulin resistance traits in two large-scale population samples, the Generation Scotland: Scottish Family Health Study (GS: SFHS; N = 19,994) and in the UK Biobank (N = 331,374). In the GS:SFHS, the polygenic risk score (PRS) for fasting insulin was associated with verbal intelligence and depression while the PRS for the homeostasis model assessment of insulin resistance was associated with verbal intelligence. Despite this overlap in genetic architecture, Mendelian randomization analyses in the GS:SFHS and in the UK Biobank samples did not yield evidence for causal associations from insulin resistance traits to either depression or cognition. These findings may be due to weak genetic instruments, limited cognitive measures and insufficient power but they may also indicate the need to identify other biological mechanisms that may mediate the relationship from insulin resistance to depression and cognition.
C1 [Frangou, Sophia] Icahn Sch Med Mt Sinai, Dept Psychiat, 1425 Madison Ave, New York, NY 10029 USA.
   [Shirali, Masoud; Adams, Mark J.; Howard, David M.; Gibson, Jude; Hall, Lynsey S.; Clarke, Toni-Kim; McIntosh, Andrew M.] Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh, Midlothian, Scotland.
   [Smith, Blair H.] Univ Dundee, Ninewells Hosp & Med Sch, Div Populat Hlth Sci, Dundee, Scotland.
   [Padmanabhan, Sandosh] Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland.
   [Murray, Alison D.] Univ Aberdeen, Aberdeen Biomed Imaging Ctr, Aberdeen, Scotland.
   [Porteous, David J.; Deary, Ian J.; McIntosh, Andrew M.] Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.
   [Porteous, David J.] Univ Edinburgh, Inst Genet & Mol Med, Ctr Genom & Expt Med, Generat Scotland,Med Genet Sect, Edinburgh, Midlothian, Scotland.
   [Haley, Chris S.] Univ Edinburgh, Inst Genet & Mol Med, Human Genet Unit, Med Res Council, Edinburgh, Midlothian, Scotland.
   [Deary, Ian J.; McIntosh, Andrew M.] Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland.
C3 Icahn School of Medicine at Mount Sinai; Royal Infirmary of Edinburgh;
   University of Edinburgh; University of Dundee; University of Glasgow;
   University of Aberdeen; University of Edinburgh; University of
   Edinburgh; UK Research & Innovation (UKRI); Medical Research Council UK
   (MRC); University of Edinburgh; University of Edinburgh
RP Frangou, S (corresponding author), Icahn Sch Med Mt Sinai, Dept Psychiat, 1425 Madison Ave, New York, NY 10029 USA.
EM sophia.frangou@mssm.edu
RI Frangou, Sophia/A-2672-2013; Murray, Alison/H-6250-2017; Haley,
   Chris/F-3110-2013; Deary, Ian/C-6297-2009; Porteous,
   David/MAI-3874-2025; Howard, David/I-6500-2019; Clarke,
   Toni/AAE-7069-2019; Smith, Blair/G-2834-2012; Shirali,
   Masoud/GYH-0339-2022; McIntosh, Andrew/B-9379-2008
OI Murray, Alison/0000-0003-4915-4847; Clarke,
   Toni-Kim/0000-0002-7745-6351; Padmanabhan, Sandosh/0000-0003-3869-5808;
   Howard, David/0000-0002-6005-1972; Smith, Blair/0000-0002-5362-9430;
   Shirali, Masoud/0000-0002-5401-0541; McIntosh,
   Andrew/0000-0002-0198-4588
FU Wellcome Trust [104036/Z/14/Z]; Medical Research Council; National
   Institute of Mental Health, USA [R01MH113619, R01MH116147]; consortium
   for Psychopathology and Allostatic load across the Life Span (PALS); Dr.
   Mortimer and Theresa Sackler Foundation; cross council Lifelong Health
   and Wellbeing Initiative [MR/K026992/1]; Chief Scientist Office of the
   Scottish Government Health Directorates [CZD/16/6]; Scottish Funding
   Council [HR03006]; Biotechnology and Biological Sciences Research
   Council; MRC [G0700704, MC_UU_00007/10] Funding Source: UKRI
FX We are grateful to the families who took part in GS:SFHS, general
   practitioners and the Scottish School of Primary Care for their help in
   recruitment, and the whole GS:SFHS team that includes academic
   researchers, clinic staff, laboratory technicians, clerical workers, IT
   staff, statisticians and research managers. The research reported here,
   and the genotyping of GS:SFHS samples was funded by the Wellcome Trust,
   (Wellcome Trust Strategic Award 'STratifying Resilience and Depression
   Longitudinally' (STRADL) Reference 104036/Z/14/Z) and by the Medical
   Research Council. SF acknowledges support from the National Institute of
   Mental Health, USA (R01MH113619; R01MH116147) and the consortium for
   Psychopathology and Allostatic load across the Life Span (PALS;
   https://www.pals-network.org) AMM acknowledges the financial support
   received from the Dr. Mortimer and Theresa Sackler Foundation. IJD and
   AMM are members of The University of Edinburgh Centre for Cognitive
   Ageing and Cognitive Epidemiology, part of the cross council Lifelong
   Health and Wellbeing Initiative (MR/K026992/1). Generation Scotland
   received core support from the Chief Scientist Office of the Scottish
   Government Health Directorates (CZD/16/6) and the Scottish Funding
   Council (HR03006). Funding from the Biotechnology and Biological
   Sciences Research Council and Medical Research Council is gratefully
   acknowledged.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Alvarez EO, 2009, BEHAV BRAIN RES, V198, P224, DOI 10.1016/j.bbr.2008.11.001
   [Anonymous], ACTA PSYCHIAT SCAND
   [Anonymous], PSYCHOSOM MED
   [Anonymous], NAT GENET
   [Anonymous], NEUROSCIENCE
   [Anonymous], GUIDE USING MILL HIL
   [Anonymous], 2013, NAT GENET
   [Anonymous], ELIFE
   [Anonymous], INT J EPIDEMIOL
   Balkau B, 1999, DIABETIC MED, V16, P442
   Benedict C, 2012, DIABETES CARE, V35, P488, DOI 10.2337/dc11-2075
   Benton AL, 1976, Multilingual Aphasia Examination
   BERGMAN RN, 1987, J CLIN INVEST, V79, P790, DOI 10.1172/JCI112886
   Biessels GJ, 2006, LANCET NEUROL, V5, P64, DOI 10.1016/S1474-4422(05)70284-2
   Bowden J, 2015, INT J EPIDEMIOL, V44, P512, DOI 10.1093/ije/dyv080
   Bulik-Sullivan B, 2015, NAT GENET, V47, P1236, DOI 10.1038/ng.3406
   Burgess S, 2013, GENET EPIDEMIOL, V37, P658, DOI 10.1002/gepi.21758
   Bycroft C, 2018, NATURE, V562, P203, DOI 10.1038/s41586-018-0579-z
   Cheng CM, 2003, J NEUROSCI RES, V73, P1, DOI 10.1002/jnr.10634
   Cheng ZY, 2010, TRENDS ENDOCRIN MET, V21, P589, DOI 10.1016/j.tem.2010.06.005
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   Cooper C, 2015, AM J PSYCHIAT, V172, P323, DOI 10.1176/appi.ajp.2014.14070878
   Cosway R, 2001, DIABETIC MED, V18, P803, DOI 10.1046/j.1464-5491.2001.00577.x
   Craft S, 2004, LANCET NEUROL, V3, P169, DOI 10.1016/S1474-4422(04)00681-7
   Davey Smith G, 2014, HUM MOL GENET, V23, pR89, DOI 10.1093/hmg/ddu328
   Derakhshan F, 2013, CURR DIABETES REV, V9, P102
   Dou JT, 2005, LEARN MEMORY, V12, P646, DOI 10.1101/lm.88005
   Dupuis J, 2010, NAT GENET, V42, P105, DOI 10.1038/ng.520
   Ekblad LL, 2015, DIABETOLOGIA, V58, P2545, DOI 10.1007/s00125-015-3715-4
   Euesden J, 2015, BIOINFORMATICS, V31, P1466, DOI 10.1093/bioinformatics/btu848
   Genuth S, 2007, NEW ENGL J MED, V356, P1842
   Golden SH, 2008, JAMA-J AM MED ASSOC, V299, P2751, DOI 10.1001/jama.299.23.2751
   Govind S, 2001, J CELL BIOL, V152, P579, DOI 10.1083/jcb.152.3.579
   Grossniklaus DA, 2012, EUR J CARDIOVASC NUR, V11, P423, DOI 10.1016/j.ejcnurse.2011.03.008
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hagenaars SP, 2016, MOL PSYCHIATR, V21, P1624, DOI 10.1038/mp.2015.225
   Hiles SA, 2016, DEPRESS ANXIETY, V33, P754, DOI 10.1002/da.22512
   Howard DM, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-03819-3
   Kan C, 2013, DIABETES CARE, V36, P480, DOI 10.2337/dc12-1442
   Knol MJ, 2006, DIABETOLOGIA, V49, P837, DOI 10.1007/s00125-006-0159-x
   Konttinen H, 2010, AM J CLIN NUTR, V92, P1031, DOI 10.3945/ajcn.2010.29732
   LAAKSO M, 1993, AM J EPIDEMIOL, V137, P959, DOI 10.1093/oxfordjournals.aje.a116768
   Lamport DJ, 2009, NEUROSCI BIOBEHAV R, V33, P394, DOI 10.1016/j.neubiorev.2008.10.008
   Leibson C L, 1997, Ann N Y Acad Sci, V826, P422, DOI 10.1111/j.1749-6632.1997.tb48496.x
   Li NS, 2014, ATHEROSCLEROSIS, V233, P130, DOI 10.1016/j.atherosclerosis.2013.12.013
   Liu Y, 2012, J AFFECT DISORDERS, V139, P230, DOI 10.1016/j.jad.2011.08.003
   Luciano M, 2014, DIABETIC MED, V31, P714, DOI 10.1111/dme.12389
   Luciano M, 2018, NAT GENET, V50, P6, DOI 10.1038/s41588-017-0013-8
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Marijnissen RM, 2017, PSYCHOL MED, V47, P1041, DOI 10.1017/S0033291716003196
   Marioni RE, 2016, EUR J HUM GENET, V24, P919, DOI 10.1038/ejhg.2015.210
   Marseglia A, 2016, J ALZHEIMERS DIS, V53, P1069, DOI 10.3233/JAD-160266
   Matsuda M, 1999, DIABETES CARE, V22, P1462, DOI 10.2337/diacare.22.9.1462
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Mielke JG, 2006, NEUROSCIENCE, V143, P165, DOI 10.1016/j.neuroscience.2006.07.055
   Mottus R, 2013, J PSYCHOSOM RES, V75, P275, DOI 10.1016/j.jpsychores.2013.06.032
   Nelson TJ, 2008, EUR J PHARMACOL, V585, P76, DOI 10.1016/j.ejphar.2008.01.051
   Neumann KF, 2008, CURR ALZHEIMER RES, V5, P438, DOI 10.2174/156720508785908919
   Ott A, 1999, NEUROLOGY, V53, P1937, DOI 10.1212/WNL.53.9.1937
   Palta P, 2014, J INT NEUROPSYCH SOC, V20, P278, DOI 10.1017/S1355617713001483
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Peila R, 2002, DIABETES, V51, P1256, DOI 10.2337/diabetes.51.4.1256
   Penninx BWJH, 2017, NEUROSCI BIOBEHAV R, V74, P277, DOI 10.1016/j.neubiorev.2016.07.003
   Preiss K, 2013, OBES REV, V14, P906, DOI 10.1111/obr.12052
   Purcell SM, 2009, NATURE, V460, P748, DOI 10.1038/nature08185
   Richardson TG, 2019, ELIFE, V8, DOI 10.7554/eLife.43657
   Riederer P, 2017, J NEURAL TRANSM, V124, P1431, DOI 10.1007/s00702-017-1763-2
   Sadanand S, 2016, DIABETES-METAB RES, V32, P132, DOI 10.1002/dmrr.2664
   Serretti A, 2010, J CLIN PSYCHIAT, V71, P1259, DOI 10.4088/JCP.09r05346blu
   Singh MK, 2019, HORM BEHAV, V108, P73, DOI 10.1016/j.yhbeh.2018.03.009
   Skeberdis VA, 2001, P NATL ACAD SCI USA, V98, P3561, DOI 10.1073/pnas.051634698
   Smith BH, 2006, BMC MED GENET, V7, DOI 10.1186/1471-2350-7-74
   Smith GD, 2004, INT J EPIDEMIOL, V33, P30, DOI 10.1093/ije/dyh132
   Solovieff N, 2013, NAT REV GENET, V14, P483, DOI 10.1038/nrg3461
   Stiles BL, 2009, ADV DRUG DELIVER REV, V61, P1276, DOI 10.1016/j.addr.2009.07.017
   Takeda S, 2010, P NATL ACAD SCI USA, V107, P7036, DOI 10.1073/pnas.1000645107
   Valenciano AI, 2006, J NEUROCHEM, V99, P524, DOI 10.1111/j.1471-4159.2006.04043.x
   Vallance JK, 2011, PREV MED, V53, P284, DOI 10.1016/j.ypmed.2011.07.013
   Van Petten C, 2004, NEUROPSYCHOLOGIA, V42, P1394, DOI 10.1016/j.neuropsychologia.2004.04.006
   Vogelzangs N, 2014, NEUROPSYCHOPHARMACOL, V39, P1624, DOI 10.1038/npp.2014.9
   Vogelzangs N, 2011, J CLIN PSYCHIAT, V72, P598, DOI 10.4088/JCP.10m06559
   Wang X, 2003, J NEUROSCI, V23, P9852
   Wechsler D., 1997, Wechsler memory scale-third edition (WMS-III)
   Wickelgren I, 1998, SCIENCE, V280, P517, DOI 10.1126/science.280.5363.517
   WOZNIAK M, 1993, NEUROCHEM INT, V22, P1, DOI 10.1016/0197-0186(93)90062-A
   Yates KF, 2012, ARTERIOSCL THROM VAS, V32, P2060, DOI 10.1161/ATVBAHA.112.252759
   Young SE, 2006, DIABETES CARE, V29, P2688, DOI 10.2337/dc06-0915
   Zeng YN, 2016, EBIOMEDICINE, V14, P161, DOI 10.1016/j.ebiom.2016.11.003
   Zhao WQ, 2001, MOL CELL ENDOCRINOL, V177, P125, DOI 10.1016/S0303-7207(01)00455-5
NR 92
TC 15
Z9 15
U1 1
U2 17
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0014-4886
EI 1090-2430
J9 EXP NEUROL
JI Exp. Neurol.
PD JUN
PY 2019
VL 316
BP 20
EP 26
DI 10.1016/j.expneurol.2019.04.001
PG 7
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA HX8NV
UT WOS:000467663500003
PM 30965038
OA Green Published, Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Kristensen, M
   Nierenberg, AA
   Ostergaard, SD
AF Kristensen, M.
   Nierenberg, A. A.
   Ostergaard, S. D.
TI Face and predictive validity of the ClockΔ19 mouse as an animal
   model for bipolar disorder: a systematic review
SO MOLECULAR PSYCHIATRY
LA English
DT Review
ID PSYCHIATRY WFSBP GUIDELINES; DEPRESSION-RELATED BEHAVIOR; METABOLIC
   SYNDROME; BIOLOGICAL TREATMENT; WORLD FEDERATION;
   SCHIZOPHRENIA-PATIENTS; CLOCK; LITHIUM; MANIA; DOPAMINE
AB Mice carrying the circadian locomotor output cycles Kaput delta 19 N-ethyl-N-nitrosoure (ENU) mutation (Clock Delta 19) are used as an animal model for bipolar disorder (BD). We aimed to systematically review the face validity (phenotypical and pathophysiological resemblance with BD) and predictive validity (responsiveness to treatments used in BD) of this model in adherence with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. We carried out a systematic search of the databases PubMed and Embase, combining search terms covering BD and Clock Delta 19. The 22 studies included in the review (from a total of 1281 identified records) show that the behavioral phenotype of the Clock Delta 19 mouse is characterized by hyperactivity, decreased anxiety-like behavior, decreased depression-like behavior and increased preference for rewarding stimuli. This is highly consistent with mania in humans. Moreover, the Clock Delta 19 mouse exhibits rapid mood cycling (a manic-like phenotype during the day followed by euthymia at night), which is consistent with BD. Chronic administration of lithium, a drug with well established mood-stabilizing effect in humans with BD, reverses the majority of the bipolar-like traits and most of the neurobiological abnormalities observed in the Clock Delta 19 mouse. In conclusion, the Clock Delta 19 mouse has substantial face validity as an animal model for BD. The predictive validity of the Clock Delta 19 mouse has primarily been investigated via studies using lithium challenge. Therefore, further studies are needed to determine how the Clock Delta 19 mouse responds to other mood-stabilizing treatments of BD such as valproate, lamotrigine, carbamazepine, oxcarbazepine, antipsychotics, electroconvulsive therapy and various light interventions.
C1 [Kristensen, M.; Ostergaard, S. D.] Aarhus Univ Hosp, Psychosis Res Unit, Risskov, Denmark.
   [Kristensen, M.; Ostergaard, S. D.] Aarhus Univ, Dept Clin Med, Aarhus, Denmark.
   [Nierenberg, A. A.] Harvard Med Sch, Massachusetts Gen Hosp, Bipolar Clin & Res Program, Boston, MA USA.
   [Ostergaard, S. D.] Aarhus Univ, Aarhus Inst Adv Studies, Aarhus, Denmark.
C3 Aarhus University; Aarhus University; Harvard University; Harvard
   University Medical Affiliates; Massachusetts General Hospital; Harvard
   Medical School; Aarhus University
RP Ostergaard, SD (corresponding author), Aarhus Univ Hosp, Dept Clin Med, Psychosis Res Unit, Skovagervej 2, DK-8240 Risskov, Denmark.
EM soeoes@rm.dk
RI Nierenberg, ANierenberg/IAR-5549-2023
OI Ostergaard, Soren Dinesen/0000-0002-8032-6208
FU Lundbeck Foundation [R165-2013-15320]
FX We are thankful to research librarian Helene Sognstrup, Aarhus
   University Library-Psychiatry, Aarhus, Denmark. SDO is supported by a
   grant from the Lundbeck Foundation (R165-2013-15320).
CR Acheson DT, 2015, J AFFECT DISORDERS, V185, P230, DOI 10.1016/j.jad.2015.06.053
   [Anonymous], PSYCHIATRICA PREGRED
   [Anonymous], J AM ACAD CHILD ADOL
   [Anonymous], BEHAV SCI BASEL
   Arey RN, 2014, MOL PSYCHIATR, V19, P342, DOI 10.1038/mp.2013.12
   Arey R, 2012, BEHAV PHARMACOL, V23, P392, DOI 10.1097/FBP.0b013e32835651fd
   Beaulé C, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007476
   BECH P, 1976, EUR J CLIN PHARMACOL, V10, P331, DOI 10.1007/BF00565622
   Benedetti F, 2003, AM J MED GENET B, V123B, P23, DOI 10.1002/ajmg.b.20038
   Benedetti F, 2007, AM J MED GENET B, V144B, P631, DOI 10.1002/ajmg.b.30475
   Bernardi RE, 2014, BEHAV NEUROSCI, V128, P468, DOI 10.1037/a0037020
   Bernardi RE, 2013, DRUG ALCOHOL DEPEN, V133, P733, DOI 10.1016/j.drugalcdep.2013.08.024
   Bollettini I, 2017, CHRONOBIOL INT, V34, P212, DOI 10.1080/07420528.2016.1260026
   Bowden CL, 2006, AM J PSYCHIAT, V163, P1199, DOI 10.1176/appi.ajp.163.7.1199
   Cassidy F, 2001, BIPOLAR DISORD, V3, P181, DOI 10.1034/j.1399-5618.2001.30403.x
   Chen G, 1999, J NEUROCHEM, V72, P1327, DOI 10.1046/j.1471-4159.2000.0721327.x
   Coque L, 2011, NEUROPSYCHOPHARMACOL, V36, P1478, DOI 10.1038/npp.2011.33
   Cosgrove VE, 2016, BIOL PSYCHIAT, V79, P62, DOI 10.1016/j.biopsych.2015.09.002
   Cousins DA, 2009, BIPOLAR DISORD, V11, P787, DOI 10.1111/j.1399-5618.2009.00760.x
   Craddock N, 2013, LANCET, V381, P1654, DOI 10.1016/S0140-6736(13)60855-7
   Cryan JF, 2004, MOL PSYCHIATR, V9, P326, DOI 10.1038/sj.mp.4001457
   de Bartolomeis A, 2014, J PSYCHOPHARMACOL, V28, P505, DOI 10.1177/0269881114523864
   Di Nicola M, 2014, J AFFECT DISORDERS, V167, P285, DOI 10.1016/j.jad.2014.06.023
   Diazgranados N, 2010, ARCH GEN PSYCHIAT, V67, P793, DOI 10.1001/archgenpsychiatry.2010.90
   Dzirasa K, 2011, J NEUROSCI, V31, P6449, DOI 10.1523/JNEUROSCI.6144-10.2011
   Dzirasa K, 2010, J NEUROSCI, V30, P16314, DOI 10.1523/JNEUROSCI.4289-10.2010
   Easton A, 2003, GENES BRAIN BEHAV, V2, P11, DOI 10.1034/j.1601-183X.2003.00002.x
   Eastwood SL, 2010, BIOL PSYCHIAT, V67, P1010, DOI 10.1016/j.biopsych.2009.12.004
   Edgar N, 2013, BIOL PSYCHIAT, V73, p150S
   Ehrlich A, 2015, PSYCHIAT RES-NEUROIM, V233, P73, DOI 10.1016/j.pscychresns.2015.05.010
   Elmslie JL, 2001, J CLIN PSYCHIAT, V62, P486, DOI 10.4088/JCP.v62n0614
   Etain B, 2011, EUR NEUROPSYCHOPHARM, V21, pS676, DOI 10.1016/j.euroneuro.2011.07.007
   Fletcher K, 2013, J AFFECT DISORDERS, V150, P50, DOI 10.1016/j.jad.2013.02.018
   Gitlin M, 2016, INT J BIPOLAR DISORD, V4, DOI 10.1186/s40345-016-0068-y
   Gold AK, 2016, NAT SCI SLEEP, V8, P207, DOI 10.2147/NSS.S85754
   Goldstein BI, 2013, J AM ACAD CHILD PSY, V52, P1026, DOI 10.1016/j.jaac.2013.07.009
   Gonzalez R, 2014, J CLIN PSYCHIAT, V75, pE323, DOI 10.4088/JCP.13r08507
   Grande I, 2016, LANCET, V387, P1561, DOI 10.1016/S0140-6736(15)00241-X
   Grunze H, 2013, WORLD J BIOL PSYCHIA, V14, P154, DOI 10.3109/15622975.2013.770551
   Grunze H, 2010, WORLD J BIOL PSYCHIA, V11, P81, DOI 10.3109/15622970903555881
   Grunze H, 2009, WORLD J BIOL PSYCHIA, V10, P85, DOI 10.1080/15622970902823202
   Hashimoto K, 2007, BIOL PSYCHIAT, V62, P1310, DOI 10.1016/j.biopsych.2007.03.017
   Heffner JL, 2011, BIPOLAR DISORD, V13, P439, DOI 10.1111/j.1399-5618.2011.00943.x
   Henriksen TEG, 2016, BIPOLAR DISORD, V18, P221, DOI 10.1111/bdi.12390
   Hong M, 1997, J BIOL CHEM, V272, P25326, DOI 10.1074/jbc.272.40.25326
   Johnson SL, 2005, CLIN PSYCHOL REV, V25, P1008, DOI 10.1016/j.cpr.2005.06.004
   Kim SW, 2006, J AFFECT DISORDERS, V92, P109, DOI 10.1016/j.jad.2005.12.040
   King DP, 1997, CELL, V89, P641, DOI 10.1016/S0092-8674(00)80245-7
   King DP, 1997, GENETICS, V146, P1049
   Kopeykina I, 2016, J AFFECT DISORDERS, V195, P1, DOI 10.1016/j.jad.2016.01.035
   Kozikowski AP, 2011, CHEMMEDCHEM, V6, P1593, DOI 10.1002/cmdc.201100188
   Logan R, 2014, NEUROPSYCHOPHARMACOL, V39, pS603
   MacCabe JH, 2010, BRIT J PSYCHIAT, V196, P109, DOI 10.1192/bjp.bp.108.060368
   Marengo E, 2015, PSYCHIAT RES, V230, P835, DOI 10.1016/j.psychres.2015.10.021
   McClung CA, 2005, P NATL ACAD SCI USA, V102, P9377, DOI 10.1073/pnas.0503584102
   McElroy SL, 2014, J CLIN PSYCHIAT, V75, P46, DOI [10.4088/JCP.13010tx4c, 10.4088/JCP.13r08634]
   Minassian A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024185
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Moon JH, 2016, EBIOMEDICINE, V11, P285, DOI 10.1016/j.ebiom.2016.08.019
   Mukherjee S, 2010, BIOL PSYCHIAT, V68, P503, DOI 10.1016/j.biopsych.2010.04.031
   Naglich A, 2017, CNS DRUGS, V31, P665, DOI 10.1007/s40263-017-0449-5
   Naylor E, 2000, J NEUROSCI, V20, P8138
   Nestler EJ, 2010, NAT NEUROSCI, V13, P1161, DOI 10.1038/nn.2647
   Ozburn AR, 2013, NEUROPSYCHOPHARMACOL, V38, P2393, DOI 10.1038/npp.2013.138
   Ozburn AR, 2012, PSYCHOPHARMACOLOGY, V223, P169, DOI 10.1007/s00213-012-2704-2
   Perry W, 2001, BIOL PSYCHIAT, V50, P418, DOI 10.1016/S0006-3223(01)01184-2
   Perry W, 2010, PSYCHIAT RES, V178, P84, DOI 10.1016/j.psychres.2010.04.032
   Perugi G, 2017, CURR NEUROPHARMACOL, V15, P359, DOI 10.2174/1570159X14666161017233642
   Phillips ML, 2013, LANCET, V381, P1663, DOI 10.1016/S0140-6736(13)60989-7
   Power RA, 2015, NAT NEUROSCI, V18, P953, DOI 10.1038/nn.4040
   Prisciandaro JJ, 2011, PSYCHIAT RES, V188, P361, DOI 10.1016/j.psychres.2011.04.030
   Teixeira PJR, 2007, REV BRAS PSIQUIATR, V29, P330, DOI 10.1590/S1516-44462007000400007
   Roybal K, 2007, P NATL ACAD SCI USA, V104, P6406, DOI 10.1073/pnas.0609625104
   Sachs G, 2006, BIPOLAR DISORD, V8, P175, DOI 10.1111/j.1399-5618.2006.00308.x
   Sidor MM, 2015, MOL PSYCHIATR, V20, P1406, DOI 10.1038/mp.2014.167
   Sidor MM, 2011, NEUROPSYCHOPHARMACOL, V36, pS92
   Spencer S, 2012, J NEUROCHEM, V123, P124, DOI 10.1111/j.1471-4159.2012.07857.x
   Turek FW, 2005, SCIENCE, V308, P1043, DOI 10.1126/science.1108750
   van Enkhuizen J, 2013, BEHAV BRAIN RES, V249, P44, DOI 10.1016/j.bbr.2013.04.023
   Vancampfort D, 2013, AM J PSYCHIAT, V170, P265, DOI 10.1176/appi.ajp.2012.12050620
   VITATERNA MH, 1994, SCIENCE, V264, P719, DOI 10.1126/science.8171325
   Vreeker A, 2016, PSYCHOL MED, V46, P807, DOI 10.1017/S0033291715002299
   Whitton AE, 2015, CURR OPIN PSYCHIATR, V28, P7, DOI 10.1097/YCO.0000000000000122
   Zarate CA Jr, 2012, BIOL PSYCHIAT, V71, P939, DOI 10.1016/j.biopsych.2011.12.010
   Zhan L, 2011, NEUROPATH APPL NEURO, V37, P206, DOI 10.1111/j.1365-2990.2010.01128.x
NR 85
TC 27
Z9 29
U1 0
U2 14
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD JAN
PY 2018
VL 23
IS 1
BP 70
EP 80
DI 10.1038/mp.2017.192
PG 11
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA FT8ZF
UT WOS:000423441000010
PM 29112195
DA 2025-06-11
ER

PT J
AU Theodosis-Nobelos, P
   Rekka, EA
AF Theodosis-Nobelos, Panagiotis
   Rekka, Eleni A.
TI The Antioxidant Potential of Vitamins and Their Implication in Metabolic
   Abnormalities
SO NUTRIENTS
LA English
DT Review
DE vitamins; oxidative stress; antioxidant activity; metabolic disorders;
   degenerative conditions
ID GLYCATION END-PRODUCTS; TRANS-RETINOIC ACID; OXIDATIVE STRESS;
   HYDROGEN-SULFIDE; HEART-FAILURE; FREE-RADICALS; D DEFICIENCY; LIPOIC
   ACID; IN-VITRO; MITOCHONDRIAL DYSFUNCTION
AB Vitamins are micronutrients necessary for the normal function of the body. Although each vitamin has different physicochemical properties and a specific role in maintaining life, they may also possess a common characteristic, i.e., antioxidant activity. Oxidative stress can harm all the main biological structures leading to protein, DNA and lipid oxidation, with concomitant impairment of the cell. It has been established that oxidative stress is implicated in several pathological conditions such as atherosclerosis, diabetes, obesity, inflammation and metabolic syndrome. In this review we investigate the influence of oxidative stress on the above conditions, examine the interrelation between oxidative stress and inflammation and point out the importance of vitamins in these processes, especially in oxidative load manipulation and metabolic abnormalities.
C1 [Theodosis-Nobelos, Panagiotis] Frederick Univ, Sch Hlth Sci, Dept Pharm, CY-1036 Nicosia, Cyprus.
   [Rekka, Eleni A.] Aristotelian Univ Thessaloniki, Sch Pharm, Dept Pharmaceut Chem, Thessaloniki 54124, Greece.
C3 Aristotle University of Thessaloniki
RP Theodosis-Nobelos, P (corresponding author), Frederick Univ, Sch Hlth Sci, Dept Pharm, CY-1036 Nicosia, Cyprus.
EM hsc.np@frederick.ac.cy; rekka@pharm.auth.gr
RI Thedosis-Nobelos, Panagiotis/MCK-4639-2025
OI Thedosis-Nompelos, Panagiotis/0000-0003-3153-6425
FX This research received no external funding.
CR Abd El-Aal A, 2018, DIABETES METAB SYND, V12, P483, DOI 10.1016/j.dsx.2018.03.013
   Abdulkhaleq LA, 2018, VET WORLD, V11, P627, DOI 10.14202/vetworld.2018.627-635
   Abdullah KM, 2018, BIOMED PHARMACOTHER, V105, P1223, DOI 10.1016/j.biopha.2018.06.085
   Al-Gubory KH, 2012, REPROD BIOMED ONLINE, V25, P551, DOI 10.1016/j.rbmo.2012.08.004
   Alexopoulos N, 2014, ATHEROSCLEROSIS, V233, P104, DOI 10.1016/j.atherosclerosis.2013.12.023
   Amisten S, 2017, ENDOCR J, V64, P325, DOI 10.1507/endocrj.EJ16-0338
   Anderson EJ, 2009, J CLIN INVEST, V119, P573, DOI 10.1172/JCI37048
   Arakawa E, 2003, J CARDIOVASC PHARM, V42, P745, DOI 10.1097/00005344-200312000-00008
   Araki A, 2017, GERIATR GERONTOL INT, V17, P1168, DOI 10.1111/ggi.12843
   Asadipooya K, 2019, J ENDOCR SOC, V3, P1799, DOI 10.1210/js.2019-00160
   Ashoori M, 2014, BRIT J NUTR, V111, P1985, DOI 10.1017/S0007114514000178
   Bâ A, 2008, CELL MOL NEUROBIOL, V28, P923, DOI 10.1007/s10571-008-9297-7
   Basta Giuseppina, 2004, Recenti Progressi in Medicina, V95, P67
   Bayraktutan U, 2000, ARTERIOSCL THROM VAS, V20, P1903, DOI 10.1161/01.ATV.20.8.1903
   Beharka AA, 2002, FREE RADICAL BIO MED, V32, P503, DOI 10.1016/S0891-5849(01)00817-6
   Bellingan GJ, 1996, J IMMUNOL, V157, P2577
   Beltramo E, 2021, ACTA DIABETOL, V58, P1433, DOI 10.1007/s00592-021-01752-4
   Berridge MJ, 2015, BIOCHEM BIOPH RES CO, V460, P53, DOI 10.1016/j.bbrc.2015.01.008
   Berridge MJ, 2015, BIOCHEM SOC T, V43, P349, DOI 10.1042/BST20140279
   Beydoun MA, 2011, J NUTR, V141, P903, DOI 10.3945/jn.110.136580
   Bhatia M, 2005, IUBMB LIFE, V57, P603, DOI 10.1080/15216540500217875
   Bikle DD, 2014, CHEM BIOL, V21, P319, DOI 10.1016/j.chembiol.2013.12.016
   Booker SJ, 2004, CHEM BIOL, V11, P10, DOI 10.1016/j.chembiol.2004.01.002
   Bradley RD, 2014, ATHEROSCLEROSIS, V233, P387, DOI 10.1016/j.atherosclerosis.2014.01.010
   BROUET I, 1995, BIOCHEM BIOPH RES CO, V206, P533, DOI 10.1006/bbrc.1995.1076
   Caturano A, 2023, CURR ISSUES MOL BIOL, V45, P6651, DOI 10.3390/cimb45080420
   Chang H, 2013, EXP THER MED, V5, P1129, DOI 10.3892/etm.2013.971
   Chen G, 2010, MITOCHONDRION, V10, P614, DOI 10.1016/j.mito.2010.08.001
   Cho KH, 2009, AM J PHYSIOL-RENAL, V297, pF106, DOI 10.1152/ajprenal.00126.2009
   Chung M, 2009, ATHEROSCLEROSIS, V205, P342, DOI 10.1016/j.atherosclerosis.2008.12.011
   Chung SSM, 2003, J AM SOC NEPHROL, V14, pS233, DOI 10.1097/01.ASN.0000077408.15865.06
   Codoñer-Franch P, 2012, J PEDIATR-US, V161, P848, DOI 10.1016/j.jpeds.2012.04.046
   Cojic M, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.610893
   Coussens LM, 2002, NATURE, V420, P860, DOI 10.1038/nature01322
   Dalto DB, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030189
   de Oliveira MR, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/140267
   Del Ben Maria, 2012, ISRN Obes, V2012, P960427, DOI 10.5402/2012/960427
   Delhalle S, 2002, ONCOGENE, V21, P3917, DOI 10.1038/sj.onc.1205489
   Demirci B, 2014, BRATISL MED J, V115, P190, DOI 10.4149/BLL_2014_040
   DiNicolantonio JJ, 2018, PROG CARDIOVASC DIS, V61, P27, DOI 10.1016/j.pcad.2018.01.009
   Dominguez-López I, 2024, J SCI FOOD AGR, V104, P875, DOI 10.1002/jsfa.12976
   Dröge W, 2002, PHYSIOL REV, V82, P47, DOI 10.1152/physrev.00018.2001
   Du JJ, 2018, PARKINSONISM RELAT D, V57, P58, DOI 10.1016/j.parkreldis.2018.07.017
   DUVALL E, 1985, IMMUNOLOGY, V56, P351
   Eidelman RS, 2004, ARCH INTERN MED, V164, P1552, DOI 10.1001/archinte.164.14.1552
   Erba F, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25042241
   Evans M, 2014, VASC HEALTH RISK MAN, V10, P89, DOI 10.2147/VHRM.S57116
   Farbstein D, 2010, MOLECULES, V15, P8098, DOI 10.3390/molecules15118098
   Fedotcheva N. I., 2012, Biofizika, V57, P820
   Feng L, 2014, FISH PHYSIOL BIOCHEM, V40, P499, DOI 10.1007/s10695-013-9861-z
   Forbes JM, 2008, DIABETES, V57, P1446, DOI 10.2337/db08-0057
   Forman HJ, 2002, AM J RESP CRIT CARE, V166, pS4, DOI 10.1164/rccm.2206007
   Friso Simonetta, 2012, Subcell Biochem, V56, P265, DOI 10.1007/978-94-007-2199-9_14
   Furukawa S., 2004, Journal of Clinical Investigation, V114, P1752, DOI 10.1172/JCI21625
   Gad A, 2018, INT J VET SCI MED, V6, P279, DOI 10.1016/j.ijvsm.2018.09.003
   Ganji SH, 2015, METABOLISM, V64, P982, DOI 10.1016/j.metabol.2015.05.002
   GANT TW, 1988, CHEM-BIOL INTERACT, V65, P157, DOI 10.1016/0009-2797(88)90052-X
   Gautam N., 2024, Hydrophilic Vitamins in Health and Disease, VVolume 29
   Glynn RJ, 2007, CIRCULATION, V116, P1497, DOI 10.1161/CIRCULATIONAHA.107.716407
   Godson C, 2000, J IMMUNOL, V164, P1663, DOI 10.4049/jimmunol.164.4.1663
   Golli F, 2010, BIOFACTORS, V36, P33, DOI 10.1002/biof.75
   Gomes MB, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-80
   Hajrezaie M, 2015, SCI REP-UK, V5, DOI 10.1038/srep12379
   Hakola L, 2024, EUR J NUTR, V63, P1329, DOI 10.1007/s00394-024-03346-6
   Halliwell B., 1999, Free Radicals in Biology and Medicine, V3rd ed., P208
   HAMBERG M, 1967, J BIOL CHEM, V242, P5336
   Harris E, 2024, JAMA-J AM MED ASSOC, V331, DOI 10.1001/jama.2024.1566
   [Anonymous], 2022, Circulation, V145, pe1033, DOI [10.1161/CIR.0000000000001063, 10.1161/CIR.0000000000001073]
   Ho RC, 2000, NUTR RES, V20, P1201, DOI 10.1016/S0271-5317(00)00201-3
   Holick MF, 2008, AM J CLIN NUTR, V87, p1080S
   Holvoet P, 2008, Verh K Acad Geneeskd Belg, V70, P193
   Hong JI, 2004, CARCINOGENESIS, V25, P1671, DOI 10.1093/carcin/bgh165
   HULTQUIST DE, 1993, AM J HEMATOL, V42, P13, DOI 10.1002/ajh.2830420105
   Hussain SP, 2007, INT J CANCER, V121, P2373, DOI 10.1002/ijc.23173
   Hussain SP, 2003, NAT REV CANCER, V3, P276, DOI 10.1038/nrc1046
   Ivanova D, 2018, REDOX BIOL, V16, P352, DOI 10.1016/j.redox.2018.03.013
   Jafari M, 2018, INDIAN HEART J, V70, pS111, DOI 10.1016/j.ihj.2018.01.031
   Jain A, 2015, J CARD FAIL, V21, P1000, DOI 10.1016/j.cardfail.2015.10.005
   Jiang Q, 2014, FREE RADICAL BIO MED, V72, P76, DOI 10.1016/j.freeradbiomed.2014.03.035
   Joshi R, 2001, FREE RADICAL BIO MED, V30, P1390, DOI 10.1016/S0891-5849(01)00543-3
   Jung S, 2017, NUTR METAB CARDIOVAS, V27, P806, DOI 10.1016/j.numecd.2017.05.008
   Kang JB, 2019, LAB ANIM RES, V35, DOI 10.1186/s42826-019-0018-9
   Kannan K, 2004, FREE RADICAL BIO MED, V36, P423, DOI 10.1016/j.freeradbiomed.2003.09.012
   Kedziora-Kornatowska K, 2010, ARCH MED SCI, V6, P513, DOI 10.5114/aoms.2010.14461
   Khatana C, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/5245308
   Khobrani M, 2023, SAUDI PHARM J, V31, P655, DOI 10.1016/j.jsps.2023.03.005
   Kim GH, 2015, EXP NEUROBIOL, V24, P325, DOI 10.5607/en.2015.24.4.325
   Kim J, 2016, NUTR RES PRACT, V10, P386, DOI 10.4162/nrp.2016.10.4.386
   Kolaczkowska E, 2010, IMMUNOBIOLOGY, V215, P492, DOI 10.1016/j.imbio.2009.07.001
   Lee BJ, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-79
   Lehmann B, 2010, DERMATOL THER, V23, P2, DOI 10.1111/j.1529-8019.2009.01286.x
   Lesková E, 2006, J FOOD COMPOS ANAL, V19, P252, DOI 10.1016/j.jfca.2005.04.014
   LEVY EJ, 1993, P NATL ACAD SCI USA, V90, P9171, DOI 10.1073/pnas.90.19.9171
   Li JR, 2009, J NEUROSCI RES, V87, P1997, DOI 10.1002/jnr.22029
   Li JL, 2012, J BIOMED SCI, V19, DOI 10.1186/1423-0127-19-32
   Li JR, 2003, J NEUROSCI, V23, P5816
   Li NS, 2014, ATHEROSCLEROSIS, V233, P130, DOI 10.1016/j.atherosclerosis.2013.12.013
   Li YP, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.116.003768
   Liang ZX, 2023, APOPTOSIS, V28, P485, DOI 10.1007/s10495-022-01801-5
   Liu KF, 2024, ARCH GERONTOL GERIAT, V117, DOI 10.1016/j.archger.2023.105230
   Liu YL, 2014, ADV CANCER RES, V122, P69, DOI 10.1016/B978-0-12-420117-0.00002-5
   Lukienko PI, 2000, B EXP BIOL MED+, V130, P874, DOI 10.1023/A:1015318413076
   Malivindi R, 2018, J CELL PHYSIOL, V233, P9526, DOI 10.1002/jcp.26872
   Masuda T, 2013, J AGR FOOD CHEM, V61, P1097, DOI 10.1021/jf304775x
   Matsuda M, 2013, OBES RES CLIN PRACT, V7, pE330, DOI 10.1016/j.orcp.2013.05.004
   Matxain JM, 2006, J PHYS CHEM A, V110, P13068, DOI 10.1021/jp065115p
   McCarty MF, 2016, MED HYPOTHESES, V95, P45, DOI 10.1016/j.mehy.2016.08.002
   Medzhitov R, 2008, NATURE, V454, P428, DOI 10.1038/nature07201
   Mikhailidis DP, 2011, CURR VASC PHARMACOL, V9, P533
   Mirhosseini N, 2017, J CLIN ENDOCR METAB, V102, P3097, DOI 10.1210/jc.2017-01024
   Miyazawa T, 2019, IUBMB LIFE, V71, P430, DOI 10.1002/iub.2008
   Morris TT, 2014, J CHROMATOGR B, V958, P16, DOI 10.1016/j.jchromb.2014.03.012
   Moses G, 2021, AUST PRESCR, V44, P119, DOI 10.18773/austprescr.2021.029
   Mosharov E, 2000, BIOCHEMISTRY-US, V39, P13005, DOI 10.1021/bi001088w
   Nakai K, 2014, AM J HYPERTENS, V27, P586, DOI 10.1093/ajh/hpt160
   Nakano E, 2001, BRIT J NUTR, V86, P637, DOI 10.1079/BJN2001478
   Nga NTT, 2019, VIETNAM J CHEM, V57, P485, DOI 10.1002/vjch.201900081
   Norman PE, 2014, CIRC RES, V114, P379, DOI 10.1161/CIRCRESAHA.113.301241
   Nosratabadi S, 2023, DIAB MET SYND CLIN R, V17, DOI 10.1016/j.dsx.2023.102824
   Obeid R, 2011, MED HYPOTHESES, V77, P884, DOI 10.1016/j.mehy.2011.08.002
   Ohta BK, 2002, J AM CHEM SOC, V124, P12064, DOI 10.1021/ja0205481
   Pacher P, 2007, PHYSIOL REV, V87, P315, DOI 10.1152/physrev.00029.2006
   Packer L, 2001, NUTRITION, V17, P888, DOI 10.1016/S0899-9007(01)00658-X
   Padayatty SJ, 2003, J AM COLL NUTR, V22, P18, DOI 10.1080/07315724.2003.10719272
   Padmanabhan S, 2019, NUTR CANCER, V71, P100, DOI 10.1080/01635581.2018.1513047
   Pekala J, 2011, CURR DRUG METAB, V12, P667, DOI 10.2174/138920011796504536
   Penberthy W.T., 2020, Present knowledge in nutrition, P289
   Pham CG, 2004, CELL, V119, P529, DOI 10.1016/j.cell.2004.10.017
   Pilz S, 2008, J CLIN ENDOCR METAB, V93, P3927, DOI 10.1210/jc.2008-0784
   Pizzino G, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/8416763
   Plummer SM, 1999, ONCOGENE, V18, P6013, DOI 10.1038/sj.onc.1202980
   Politis A, 2010, J ALZHEIMERS DIS, V19, P481, DOI 10.3233/JAD-2010-1252
   Popa DS, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10040566
   Powers HJ, 2003, AM J CLIN NUTR, V77, P1352
   Prigge ST, 1997, BIOCHIMIE, V79, P629, DOI 10.1016/S0300-9084(97)83495-5
   Qu H, 2018, J AM HEART ASSOC, V7, DOI [10.1161/JAHA.118.009835, 10.1161/jaha.118.009835]
   Rennen H.J.J.M., 2006, Diagnostic Nuclear Medicine, V2nd ed., P114
   Reuter S, 2010, FREE RADICAL BIO MED, V49, P1603, DOI 10.1016/j.freeradbiomed.2010.09.006
   Ricca C, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19061672
   Rietjens IMCM, 2002, ENVIRON TOXICOL PHAR, V11, P321, DOI 10.1016/S1382-6689(02)00003-0
   Riverón-Negrete L, 2016, BIOMED RES INT, V2016, DOI 10.1155/2016/7276463
   Robinson Irina, 2006, Endocr Pract, V12, P576
   Rodriguez-Melendez R, 2009, J NUTR, V139, P429, DOI 10.3945/jn.108.101840
   Rovira-Llopis S, 2017, REDOX BIOL, V11, P637, DOI 10.1016/j.redox.2017.01.013
   Rungratanawanich W, 2021, EXP MOL MED, V53, P168, DOI 10.1038/s12276-021-00561-7
   Safarinejad MR, 2010, INT J IMPOT RES, V22, P298, DOI 10.1038/ijir.2010.20
   Saljooghi AS, 2010, TOXICOL IND HEALTH, V26, P195, DOI 10.1177/0748233710362375
   Sanlioglu S, 2001, J BIOL CHEM, V276, P30188, DOI 10.1074/jbc.M102061200
   Sarir H, 2015, J RES MED SCI, V20, P1177, DOI 10.4103/1735-1995.172986
   Satapathy S, 2020, COMPLEMENT THER MED, V53, DOI 10.1016/j.ctim.2020.102526
   Sato H, 2013, NEUROSCIENCE, V248, P345, DOI 10.1016/j.neuroscience.2013.06.010
   Schniertshauer D, 2016, PHOTOCHEM PHOTOBIOL, V92, P488, DOI 10.1111/php.12583
   Schulze-Osthoff K, 1998, EUR J BIOCHEM, V254, P439, DOI 10.1046/j.1432-1327.1998.2540439.x
   SchulzeOsthoff K, 1997, INT J VITAM NUTR RES, V67, P336
   Sekiguchi F, 2014, BIOCHEM BIOPH RES CO, V445, P225, DOI 10.1016/j.bbrc.2014.01.185
   Sengupta Avery, 2013, Pak J Biol Sci, V16, P59, DOI 10.3923/pjbs.2013.59.66
   Sghaier R, 2019, FREE RADICAL RES, V53, P535, DOI 10.1080/10715762.2019.1612891
   Shimizu H, 2018, J CELL PHYSIOL, V233, P607, DOI 10.1002/jcp.25921
   Siasos G, 2018, ANN TRANSL MED, V6, DOI 10.21037/atm.2018.06.21
   Smith WL, 2019, J BIOL CHEM, V294, P1697, DOI 10.1074/jbc.TM118.006295
   Song C, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-00796-3
   Stirban A, 2006, DIABETES CARE, V29, P2064, DOI 10.2337/dc06-0531
   Storkey C, 2014, FREE RADICAL BIO MED, V73, P60, DOI 10.1016/j.freeradbiomed.2014.04.024
   Sun PF, 2022, FRONT CARDIOVASC MED, V9, DOI 10.3389/fcvm.2022.906232
   Sutton G, 2019, AM J HYPERTENS, V32, P813, DOI 10.1093/ajh/hpz091
   Suwannasom N, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21030950
   Takemura Y, 2010, BIOCHEM BIOPH RES CO, V394, P249, DOI 10.1016/j.bbrc.2010.02.012
   Tan BL, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112579
   Taylor JK, 2015, REDOX REP, V20, DOI 10.1179/1351000214Y.0000000103
   Taylor NL, 2004, PLANT PHYSIOL, V134, P838, DOI 10.1104/pp.103.035675
   Terruzzi I, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/5678548
   Tetich A, 2004, J STEROID BIOCHEM, V89-90, P365, DOI 10.1016/j.jsbmb.2004.03.018
   Theodosis-Nobelos P, 2021, MOL BIOL REP, V48, P6539, DOI 10.1007/s11033-021-06643-z
   Theodosis-Nobelos P, 2021, MINI-REV MED CHEM, V21, P10, DOI 10.2174/1389557520666200807132617
   Theodosis-Nobelos P, 2020, MOLECULES, V25, DOI 10.3390/molecules25010019
   Theodosis-Nobelos P, 2017, BIOORG MED CHEM LETT, V27, P4800, DOI 10.1016/j.bmcl.2017.09.054
   TOYOSAKI T, 1992, J AGR FOOD CHEM, V40, P1727, DOI 10.1021/jf00022a001
   Traber MG, 2008, NUTR REV, V66, P624, DOI 10.1111/j.1753-4887.2008.00123.x
   Trasino Steven E, 2015, Diabetes Manag (Lond), V5, P359
   Trasino SE, 2015, J BIOL CHEM, V290, P1456, DOI 10.1074/jbc.M114.616763
   Trueblood NA, 2000, AM J PHYSIOL-HEART C, V279, pH764, DOI 10.1152/ajpheart.2000.279.2.H764
   Trujillo Madia, 2007, V44, P83
   Tseng AHH, 2013, FREE RADICAL BIO MED, V63, P222, DOI 10.1016/j.freeradbiomed.2013.05.002
   Tsiakitzis K, 2005, ARCH PHARM, V338, P315, DOI 10.1002/ardp.200400946
   Tsolaki E, 2014, CURR TOP MED CHEM, V14, P2462, DOI 10.2174/1568026614666141203120425
   Tupe RS, 2011, BRIT J NUTR, V105, P1741, DOI 10.1017/S0007114510005520
   Urvalek AM, 2014, J BIOL CHEM, V289, P19519, DOI 10.1074/jbc.M114.556555
   van de Lagemaat EE, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020482
   Verdrengh M, 2005, INFLAMM RES, V54, P390, DOI 10.1007/s00011-005-1372-7
   Wadhwa S, 2013, CANCER LETT, V337, P8, DOI 10.1016/j.canlet.2013.05.027
   Wallace JL, 2007, TRENDS PHARMACOL SCI, V28, P501, DOI 10.1016/j.tips.2007.09.003
   Wang GG, 2011, HEART INT, V6, P75, DOI 10.4081/hi.2011.e21
   Wang TJ, 2008, CIRCULATION, V117, P503, DOI 10.1161/CIRCULATIONAHA.107.706127
   Watanabe Reiko, 2015, Clin Calcium, V25, P373, DOI CliCa1503373380
   Wautier MP, 2001, AM J PHYSIOL-ENDOC M, V280, pE685, DOI 10.1152/ajpendo.2001.280.5.E685
   Wimalawansa SJ, 2019, BIOLOGY-BASEL, V8, DOI 10.3390/biology8020030
   Wojtczak L, 2003, BIOFACTORS, V17, P61, DOI 10.1002/biof.5520170107
   Wu JQ, 2013, PROG NEURO-PSYCHOPH, V46, P200, DOI 10.1016/j.pnpbp.2013.02.015
   Wu WH, 2013, ACTA BIOCH BIOPH SIN, V45, P18, DOI 10.1093/abbs/gms104
   Yan XY, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000022272
   Younis N, 2009, ATHEROSCLEROSIS, V202, P162, DOI 10.1016/j.atherosclerosis.2008.04.036
   Zhang PN, 2021, J DIABETES RES, V2021, DOI 10.1155/2021/1010268
   Zhang YJ, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.1046800
NR 203
TC 3
Z9 3
U1 9
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2024
VL 16
IS 16
AR 2740
DI 10.3390/nu16162740
PG 25
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA E8O1N
UT WOS:001305529200001
PM 39203876
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Esteve, M
AF Esteve, Montserrat
TI Mechanisms Underlying Biological Effects of Cruciferous
   Glucosinolate-Derived Isothiocyanates/Indoles: A Focus on Metabolic
   Syndrome
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE cruciferous; glucosinolates; isothiocyanates; indoles; metabolic
   syndrome; inflammation; Nuclear erythroid 2-related factor (Nrf2);
   Nuclear Factor-kappa B (NF-kappa B)
ID CELL-CYCLE ARREST; NF-KAPPA-B; PROSTATE-CANCER CELLS; DIFFERENT COOKING
   METHODS; GLYCATION END-PRODUCTS; SULFORAPHANE INDUCES APOPTOSIS; HISTONE
   DEACETYLASE ACTIVITY; ULTRA-PROCESSED FOODS; PHENETHYL ISOTHIOCYANATE;
   ADIPOSE-TISSUE
AB An inverse correlation between vegetable consumption and the incidence of cancer has long been described. This protective effect is stronger when cruciferous vegetables are specifically consumed. The beneficial properties of vegetables are attributed to their bioactive components like fiber, antioxidants vitamins, antioxidants, minerals, and phenolic compounds. Cruciferous vegetables contain all these molecules; however, what makes them different are their sulfurous components, called glucosinolates, responsible for their special smell and taste. Glucosinolates are inactive biologically in the organism but are hydrolyzed by the enzyme myrosinase released as a result of chewing, leading to the formation of active derivatives such as isothiocyanates and indoles. A considerable number ofin vitroandin vivostudies have reported that isothiocyanates and indoles elicit chemopreventive potency through multiple mechanisms that include modulation of phases I and II detoxification pathway enzymes, regulation of cell cycle arrest, and control of cell growth, induction of apoptosis, antioxidant activity, anti-angiogenic effects, and epigenetic regulation. Nuclear erythroid 2-related factor 2 (Nrf2) and Nuclear factor-kappa B (NF-kappa B) are key and central regulators in all these processes with a main role in oxidative stress and inflammation control. It has been described that isothiocyanates and indoles regulate their activity directly and indirectly. Today, the metabolic syndrome (central obesity, insulin resistance, hyperlipidemia, and hypertension) is responsible for a majority of deaths worldwide. All components of metabolic syndrome are characterized by chronic inflammation with deregulation of the PI3K/AKT/mTOR, MAPK/EKR/JNK, Nrf2, and NF-kappa B signaling pathways. The effects of GLSs derivatives controlling these pathways have been widely described in relation to cancer. Changes in food consumption patterns observed in the last decades to higher consumption of ultra-processed foods, with elevation in simple sugar and saturated fat contents and lower consumption of vegetables and fruits have been directly correlated with metabolic syndrome prevalence. In this review, it is summarized the knowledge regarding the mechanisms by which cruciferous glucosinolate derivatives (isothiocyanates and indoles) directly and indirectly regulate these pathways. However, the review places a special focus on the knowledge of the effects of glucosinolates derivatives in metabolic syndrome, since this has not been reviewed before.
C1 [Esteve, Montserrat] Univ Barcelona, Dept Biochem & Mol Biomed, Barcelona, Spain.
   [Esteve, Montserrat] Inst Hlth Carlos III, Biomed Res Ctr Physiopathol Obes & Nutr CIBERobn, Madrid, Spain.
C3 University of Barcelona; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN
RP Esteve, M (corresponding author), Univ Barcelona, Dept Biochem & Mol Biomed, Barcelona, Spain.; Esteve, M (corresponding author), Inst Hlth Carlos III, Biomed Res Ctr Physiopathol Obes & Nutr CIBERobn, Madrid, Spain.
EM mesteve@ub.edu
RI Esteve, Montserrat/L-6272-2014
OI Esteve, Montserrat/0000-0003-2128-7859
CR Abbaoui B, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201800079
   Abbaoui B, 2017, J PROTEOMICS, V156, P94, DOI 10.1016/j.jprot.2017.01.013
   Abbaoui B, 2012, MOL NUTR FOOD RES, V56, P1675, DOI 10.1002/mnfr.201200276
   Aggarwal BB, 2005, CELL CYCLE, V4, P1201, DOI 10.4161/cc.4.9.1993
   Aggarwal BB, 2011, CANCER DISCOV, V1, P469, DOI 10.1158/2159-8290.CD-11-0260
   Ahmad A, 2013, ANTI-CANCER AGENT ME, V13, P1002, DOI 10.2174/18715206113139990078
   Ahn J, 2014, J NUTR BIOCHEM, V25, P1026, DOI 10.1016/j.jnutbio.2014.05.006
   Akhavan-Niaki H, 2013, CELL BIOCHEM BIOPHYS, V67, P501, DOI 10.1007/s12013-013-9555-2
   Anderton MJ, 2004, CLIN CANCER RES, V10, P5233, DOI 10.1158/1078-0432.CCR-04-0163
   Anderton MJ, 2004, DRUG METAB DISPOS, V32, P632, DOI 10.1124/dmd.32.6.632
   [Anonymous], 2006, IDF CONS WORLDW DEF
   [Anonymous], MET SYNDR
   [Anonymous], Metabolic syndrome
   Atwell LL, 2015, MOL NUTR FOOD RES, V59, P424, DOI 10.1002/mnfr.201400674
   Bahadoran Z, 2012, INT J FOOD SCI NUTR, V63, P767, DOI 10.3109/09637486.2012.665043
   Bai Y, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/407580
   Baker RG, 2011, CELL METAB, V13, P11, DOI 10.1016/j.cmet.2010.12.008
   Batra S, 2010, MOL CANCER THER, V9, P1596, DOI 10.1158/1535-7163.MCT-09-1146
   Bayat Mokhtari Reza, 2018, J Cell Commun Signal, V12, P91, DOI 10.1007/s12079-017-0401-y
   Bazzano LA, 2008, DIABETES CARE, V31, P1311, DOI 10.2337/dc08-0080
   Beaver LM, 2012, TOXICOL APPL PHARM, V263, P345, DOI 10.1016/j.taap.2012.07.007
   Benazzi C, 2014, SCI WORLD J, DOI 10.1155/2014/919570
   Bertl E, 2006, MOL CANCER THER, V5, P575, DOI 10.1158/1535-7163.MCT-05-0324
   Bhupathiraju Shilpa N, 2013, Am J Clin Nutr, V98, P1514, DOI 10.3945/ajcn.113.066381
   Bjelakovic G, 2012, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD007176.pub2, 10.1590/1516-3180.20151332T1]
   Boldry EJ, 2020, CANCER PREV RES, V13, P91, DOI 10.1158/1940-6207.CAPR-19-0296
   Bowman GL, 2019, ALZH DEMENT-TRCI, V5, P953, DOI 10.1016/j.trci.2019.11.004
   Boyanapalli SSS, 2016, PHARMACOL RES, V114, P175, DOI 10.1016/j.phrs.2016.10.021
   Brew CT, 2006, INT J CANCER, V118, P857, DOI 10.1002/ijc.21445
   BRUSEWITZ G, 1977, BIOCHEM J, V162, P99
   BUCALA R, 1994, P NATL ACAD SCI USA, V91, P9441, DOI 10.1073/pnas.91.20.9441
   Busbee PB, 2014, TOXICOL APPL PHARM, V274, P7, DOI 10.1016/j.taap.2013.10.022
   Caglayan B, 2019, MOL BIOL REP, V46, P241, DOI 10.1007/s11033-018-4465-4
   Cartea ME, 2008, PHYTOCHEMISTRY, V69, P403, DOI 10.1016/j.phytochem.2007.08.014
   Catrysse L, 2017, TRENDS CELL BIOL, V27, P417, DOI 10.1016/j.tcb.2017.01.006
   Chae SY, 2015, J FUNCT FOODS, V19, P700, DOI 10.1016/j.jff.2015.09.060
   Chang HP, 2011, INT J OBESITY, V35, P1530, DOI 10.1038/ijo.2011.12
   Chen D, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047186
   Chen DZ, 2004, ANTICANCER RES, V24, P2649
   Chen DZ, 2001, J NUTR, V131, P3294, DOI 10.1093/jn/131.12.3294
   Chen I, 1998, CARCINOGENESIS, V19, P1631, DOI 10.1093/carcin/19.9.1631
   Chen J, 2018, J AGR FOOD CHEM, V66, P11926, DOI 10.1021/acs.jafc.8b04330
   Cheng DL, 2004, FOOD CHEM TOXICOL, V42, P351, DOI [10.1016/j.fct.2003.09.008, 10.1016/J.FCT.2003.09.008]
   Chiao JW, 2002, INT J ONCOL, V20, P631
   Chiao JW, 2000, INT J ONCOL, V16, P1215
   Chinni SR, 2001, ONCOGENE, V20, P2927, DOI 10.1038/sj.onc.1204365
   Chinni SR, 2002, CLIN CANCER RES, V8, P1228
   Choi HS, 2014, BIOCHIMIE, V104, P127, DOI 10.1016/j.biochi.2014.06.010
   Choi KM, 2014, J NUTR BIOCHEM, V25, P201, DOI 10.1016/j.jnutbio.2013.10.007
   Choi KM, 2012, OBESITY, V20, P1365, DOI 10.1038/oby.2011.388
   Christiansen B, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012461
   Chuang WT, 2019, J AGR FOOD CHEM, V67, P7136, DOI 10.1021/acs.jafc.9b02668
   Chun TH, 2006, CELL, V125, P577, DOI 10.1016/j.cell.2006.02.050
   Cinti S, 2005, J LIPID RES, V46, P2347, DOI 10.1194/jlr.M500294-JLR200
   Clária J, 2011, FRONT IMMUNOL, V2, DOI 10.3389/fimmu.2011.00049
   Coles BF, 2005, METHOD ENZYMOL, V401, P9, DOI 10.1016/S0076-6879(05)01002-5
   Coles BF, 2003, BIOFACTORS, V17, P115, DOI 10.1002/biof.5520170112
   Conaway CC, 2002, CURR DRUG METAB, V3, P233, DOI 10.2174/1389200023337496
   Conaway CC, 2000, NUTR CANCER, V38, P168, DOI 10.1207/S15327914NC382_5
   Conaway CC, 1999, DRUG METAB DISPOS, V27, P13
   Cooper AJ, 2012, DIABETES CARE, V35, P1293, DOI 10.2337/dc11-2388
   Cover CM, 1998, J BIOL CHEM, V273, P3838, DOI 10.1074/jbc.273.7.3838
   DEKRUIF CA, 1991, CHEM-BIOL INTERACT, V80, P303, DOI 10.1016/0009-2797(91)90090-T
   Drewnowski A, 2007, EPIDEMIOL REV, V29, P160, DOI 10.1093/epirev/mxm011
   DUNN FL, 1982, MED CLIN N AM, V66, P1347, DOI 10.1016/S0025-7125(16)31368-2
   Eckschlager T, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18071414
   Elfoul L, 2001, FEMS MICROBIOL LETT, V197, P99, DOI 10.1111/j.1574-6968.2001.tb10589.x
   Elgazar-Carmon V, 2008, J LIPID RES, V49, P1894, DOI 10.1194/jlr.M800132-JLR200
   Ernst IMA, 2011, PHARMACOL RES, V63, P233, DOI 10.1016/j.phrs.2010.11.005
   Ràfols ME, 2014, ENDOCRINOL NUTR, V61, P100, DOI 10.1016/j.endonu.2013.03.011
   Fahey JW, 2001, PHYTOCHEMISTRY, V56, P5, DOI 10.1016/S0031-9422(00)00316-2
   Farazi TA, 2008, DEVELOPMENT, V135, P1201, DOI 10.1242/dev.005629
   Farvid MS, 2016, BMJ-BRIT MED J, V353, DOI 10.1136/bmj.i2343
   FENWICK GR, 1983, CRC CR REV FOOD SCI, V18, P123, DOI 10.1080/10408398209527361
   Feuerer M, 2009, NAT MED, V15, P930, DOI 10.1038/nm.2002
   Fimognari C, 2002, CARCINOGENESIS, V23, P581, DOI 10.1093/carcin/23.4.581
   Fimognari C, 2002, CELL MOL LIFE SCI, V59, P2004, DOI 10.1007/PL00012523
   Finley JW, 2005, ANN BOT-LONDON, V95, P1075, DOI 10.1093/aob/mci123
   Fraga MF, 2005, NAT GENET, V37, P391, DOI 10.1038/ng1531
   Fujioka N, 2014, CANCER EPIDEM BIOMAR, V23, P282, DOI 10.1158/1055-9965.EPI-13-0645
   Gamet-Payrastre L, 2000, CANCER RES, V60, P1426
   Goldin A, 2006, CIRCULATION, V114, P597, DOI 10.1161/CIRCULATIONAHA.106.621854
   GUO ZY, 1992, CARCINOGENESIS, V13, P2205, DOI 10.1093/carcin/13.12.2205
   Gupta B, 2013, FOOD CHEM, V141, P1841, DOI 10.1016/j.foodchem.2013.05.006
   Hajra S, 2018, CHEM-BIOL INTERACT, V290, P19, DOI 10.1016/j.cbi.2018.05.005
   Hargraves KG, 2016, MOL CARCINOGEN, V55, P486, DOI 10.1002/mc.22296
   HASEGAWA T, 1993, ANTI-CANCER DRUG, V4, P273, DOI 10.1097/00001813-199304000-00021
   He FJ, 2007, J HUM HYPERTENS, V21, P717, DOI 10.1038/sj.jhh.1002212
   Hecht SS, 2000, DRUG METAB REV, V32, P395, DOI 10.1081/DMR-100102342
   Hecht SS, 1999, CANCER EPIDEM BIOMAR, V8, P907
   Heilbronn LK, 2008, CURR PHARM DESIGN, V14, P1225, DOI 10.2174/138161208784246153
   Higdon JV, 2007, PHARMACOL RES, V55, P224, DOI 10.1016/j.phrs.2007.01.009
   Ho E, 2009, J NUTR, V139, P2393, DOI 10.3945/jn.109.113332
   Ho JN, 2013, MOL MED REP, V7, P384, DOI 10.3892/mmr.2012.1198
   Holst B, 2004, NAT PROD REP, V21, P425, DOI 10.1039/b204039p
   Hsu A, 2011, CLIN EPIGENETICS, V3, DOI 10.1186/1868-7083-3-3
   Hu R, 2003, CARCINOGENESIS, V24, P1361, DOI 10.1093/carcin/bgg092
   Huang C, 2019, EUR J PHARMACOL, V853, P153, DOI 10.1016/j.ejphar.2019.03.010
   Huang CS, 2013, MOL NUTR FOOD RES, V57, P1918, DOI 10.1002/mnfr.201300063
   Islam SS, 2016, TARGET ONCOL, V11, P209, DOI 10.1007/s11523-015-0386-5
   Iyanagi T, 2007, INT REV CYTOL, V260, P35, DOI 10.1016/S0074-7696(06)60002-8
   Izzotti A, 2010, CANCER PREV RES, V3, P62, DOI 10.1158/1940-6207.CAPR-09-0202
   Jansson MD, 2012, MOL ONCOL, V6, P590, DOI 10.1016/j.molonc.2012.09.006
   Jayakumar P, 2014, J PHYSIOL BIOCHEM, V70, P525, DOI 10.1007/s13105-014-0332-5
   Jernås M, 2006, FASEB J, V20, P1540, DOI 10.1096/fj.05-5678fje
   Jiang SH, 2010, J HEMATOL ONCOL, V3, DOI 10.1186/1756-8722-3-48
   JIAO D, 1994, CANCER RES, V54, P4327
   Jo GH, 2014, INT J ONCOL, V45, P1497, DOI 10.3892/ijo.2014.2536
   Johnson AR, 2012, IMMUNOL REV, V249, P218, DOI 10.1111/j.1600-065X.2012.01151.x
   Juul F, 2018, BRIT J NUTR, V120, P90, DOI [10.1017/S0007114518001046, 10.1017/s0007114518001046]
   Kaiser J, 2014, SCIENCE, V343, P477, DOI 10.1126/science.343.6170.477
   Kang B, 2019, PHYTOTHER RES, V33, P1426, DOI 10.1002/ptr.6333
   Kang K, 2008, CELL METAB, V7, P485, DOI 10.1016/j.cmet.2008.04.002
   Kasiappan R, 2016, J BIOL CHEM, V291, P27122, DOI 10.1074/jbc.M116.746339
   Kassahun K, 1997, CHEM RES TOXICOL, V10, P1228, DOI 10.1021/tx970080t
   Kaufman-Szymczyk A, 2015, INT J MOL SCI, V16, P29732, DOI 10.3390/ijms161226195
   Keum YS, 2003, PHARM RES-DORDR, V20, P1351, DOI 10.1023/A:1025737622815
   Kikuchi M, 2015, WORLD J GASTROENTERO, V21, P12457, DOI 10.3748/wjg.v21.i43.12457
   Kim DH, 2015, INT J ONCOL, V47, P2226, DOI 10.3892/ijo.2015.3200
   Kim HW, 2014, TOXICOL SCI, V137, P158, DOI 10.1093/toxsci/kft240
   Kim YJ, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0132151
   Kim YH, 2009, INFLAMM BOWEL DIS, V15, P1164, DOI 10.1002/ibd.20917
   Kintscher U, 2008, ARTERIOSCL THROM VAS, V28, P1304, DOI 10.1161/ATVBAHA.108.165100
   KLEIN RL, 1995, DIABETES, V44, P1093, DOI 10.2337/diabetes.44.9.1093
   Kliebenstein DJ, 2001, PLANT PHYSIOL, V126, P811, DOI 10.1104/pp.126.2.811
   Kobayashi M, 2006, ADV ENZYME REGUL, V46, P113, DOI 10.1016/j.advenzreg.2006.01.007
   Krul C, 2002, CARCINOGENESIS, V23, P1009, DOI 10.1093/carcin/23.6.1009
   Kushad MM, 1999, J AGR FOOD CHEM, V47, P1541, DOI 10.1021/jf980985s
   Lai KC, 2010, J AGR FOOD CHEM, V58, P2935, DOI 10.1021/jf9036694
   Lai RH, 2010, FOOD FUNCT, V1, P161, DOI 10.1039/c0fo00110d
   Lambrix V, 2001, PLANT CELL, V13, P2793, DOI 10.1105/tpc.13.12.2793
   Lan FM, 2015, J NEUROCHEM, V134, P811, DOI 10.1111/jnc.13174
   Langeveld M, 2017, AM J CLIN NUTR, V106, P1197, DOI 10.3945/ajcn.116.148395
   Lascar N, 2018, LANCET DIABETES ENDO, V6, P69, DOI 10.1016/S2213-8587(17)30186-9
   Leclercq I, 1998, CLIN PHARMACOL THER, V64, P144, DOI 10.1016/S0009-9236(98)90147-3
   Lee CS, 2015, ONCOL REP, V34, P2901, DOI 10.3892/or.2015.4292
   Lee YM, 2009, J MOL MED, V87, P1251, DOI 10.1007/s00109-009-0532-6
   Lee YS, 2014, CELL, V157, P1339, DOI 10.1016/j.cell.2014.05.012
   Leoncini E, 2011, J FOOD SCI, V76, pH175, DOI 10.1111/j.1750-3841.2011.02311.x
   Lewis S, 2002, IARC Sci Publ, V156, P507
   Li CX, 2019, WORLD J GASTROENTERO, V25, P5120, DOI 10.3748/wjg.v25.i34.5120
   Li JF, 1997, J BIOL CHEM, V272, P16498, DOI 10.1074/jbc.272.26.16498
   Liang H, 2008, J NAT PROD, V71, P1911, DOI 10.1021/np800233q
   Licznerska B, 2016, ADV EXP MED BIOL, V928, P131, DOI 10.1007/978-3-319-41334-1_6
   Lindsey JB, 2009, DIABETES CARE, V32, P1218, DOI 10.2337/dc09-0053
   Liu RH, 2004, J NUTR, V134, p3479S, DOI 10.1093/jn/134.12.3479S
   Liu XJ, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030262
   Lock EA, 1998, TOXICOL PATHOL, V26, P18, DOI 10.1177/019262339802600102
   London SJ, 2000, LANCET, V356, P724, DOI 10.1016/S0140-6736(00)02631-3
   Ma L, 2018, AM J CLIN NUTR, V107, P617, DOI 10.1093/ajcn/nqy003
   Machado PP, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2019-029544
   Machado PP, 2020, EUR J NUTR, V59, P2783, DOI 10.1007/s00394-019-02125-y
   Marconett CN, 2012, MOL CELL ENDOCRINOL, V363, P74, DOI 10.1016/j.mce.2012.07.008
   Mathieu P, 2009, HYPERTENSION, V53, P577, DOI 10.1161/HYPERTENSIONAHA.108.110320
   Matsui TA, 2007, ONCOL REP, V18, P1263
   Medzhitov R, 2009, NAT REV IMMUNOL, V9, P692, DOI 10.1038/nri2634
   Meeran SM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0037748
   Meeran SM, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011457
   Melchini A, 2009, FOOD CHEM TOXICOL, V47, P1430, DOI 10.1016/j.fct.2009.03.024
   Melkamu T, 2010, CARCINOGENESIS, V31, P252, DOI 10.1093/carcin/bgp208
   MENNICKE WH, 1987, J CHROMATOGR-BIOMED, V414, P19, DOI 10.1016/0378-4347(87)80020-8
   MENNICKE WH, 1983, XENOBIOTICA, V13, P203, DOI 10.3109/00498258309052256
   MENNICKE WH, 1988, XENOBIOTICA, V18, P441, DOI 10.3109/00498258809041680
   Miglio C, 2008, J AGR FOOD CHEM, V56, P139, DOI 10.1021/jf072304b
   Miyoshi N, 2004, BIOFACTORS, V21, P23, DOI 10.1002/biof.552210106
   Monteillier A, 2018, MOLECULES, V23, DOI 10.3390/molecules23030636
   Monteiro CA, 2019, PUBLIC HEALTH NUTR, V22, P936, DOI 10.1017/S1368980018003762
   Monteiro CA, 2018, PUBLIC HEALTH NUTR, V21, P18, DOI 10.1017/S1368980017001379
   Mori N, 2013, J NUTR SCI VITAMINOL, V59, P56, DOI 10.3177/jnsv.59.56
   Morimitsu Y, 2002, J BIOL CHEM, V277, P3456, DOI 10.1074/jbc.M110244200
   Morris MC, 2015, ALZHEIMERS DEMENT, V11, P32, DOI 10.1016/j.jalz.2013.12.015
   Moserle L, 2013, J INTERN MED, V273, P128, DOI 10.1111/joim.12018
   Mullaney JA, 2013, J AGR FOOD CHEM, V61, P3039, DOI 10.1021/jf305442j
   Myzak MC, 2006, CARCINOGENESIS, V27, P811, DOI 10.1093/carcin/bgi265
   Nagata N, 2017, DIABETES, V66, P1222, DOI 10.2337/db16-0662
   Nakajima M, 2001, DRUG METAB DISPOS, V29, P1110
   Nardocci M, 2019, CAN J PUBLIC HEALTH, V110, P4, DOI 10.17269/s41997-018-0130-x
   Neri D, 2019, PEDIATR OBES, V14, DOI 10.1111/ijpo.12563
   Nho CW, 2001, TOXICOL APPL PHARM, V174, P146, DOI 10.1006/taap.2001.9207
   Nour M, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111626
   Odegaard JI, 2008, CELL METAB, V7, P496, DOI 10.1016/j.cmet.2008.04.003
   Okulicz M, 2010, PLANT FOOD HUM NUTR, V65, P217, DOI 10.1007/s11130-010-0183-3
   Oliviero T, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201701069
   Paik WH, 2013, ANTICANCER RES, V33, P1473
   Palermo M, 2014, J SCI FOOD AGR, V94, P1057, DOI 10.1002/jsfa.6478
   PALOP ML, 1995, INT J FOOD MICROBIOL, V26, P219, DOI 10.1016/0168-1605(95)00123-2
   Pan JH, 2018, CRIT REV FOOD SCI, V58, P2026, DOI 10.1080/10408398.2017.1300134
   Patel B, 2018, FREE RADICAL BIO MED, V122, P150, DOI 10.1016/j.freeradbiomed.2018.02.004
   Pellegrini N, 2010, J AGR FOOD CHEM, V58, P4310, DOI 10.1021/jf904306r
   Petri N, 2003, DRUG METAB DISPOS, V31, P805, DOI 10.1124/dmd.31.6.805
   Plate AYA, 2006, CARCINOGENESIS, V27, P287, DOI 10.1093/carcin/bgi210
   Prawan A, 2009, CHEM-BIOL INTERACT, V179, P202, DOI 10.1016/j.cbi.2008.12.014
   Pulgaron ER, 2014, CURR DIABETES REP, V14, DOI 10.1007/s11892-014-0508-y
   Radzikowska U, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122990
   Rajendran P, 2013, EPIGENETICS-US, V8, P612, DOI 10.4161/epi.24710
   Rauber F, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-027546
   Rauber F, 2018, NUTRIENTS, V10, DOI 10.3390/nu10050587
   Rausch ME, 2008, INT J OBESITY, V32, P451, DOI 10.1038/sj.ijo.0803744
   Razis AFA, 2010, TOXICOLOGY, V277, P74, DOI 10.1016/j.tox.2010.08.080
   Reed GA, 2005, CANCER EPIDEM BIOMAR, V14, P1953, DOI 10.1158/1055-9965.EPI-05-0121
   Reed GA, 2006, CANCER EPIDEM BIOMAR, V15, P2477, DOI 10.1158/1055-9965.EPI-06-0396
   Riboli E, 2003, AM J CLIN NUTR, V78, p559S, DOI 10.1093/ajcn/78.3.559S
   Rodrigues AS, 1999, J SCI FOOD AGR, V79, P1028, DOI 10.1002/(SICI)1097-0010(19990515)79:7<1028::AID-JSFA322>3.0.CO;2-I
   Rungapamestry V, 2007, P NUTR SOC, V66, P69, DOI 10.1017/S0029665107005319
   Saw CLL, 2011, BIOPHARM DRUG DISPOS, V32, P289, DOI 10.1002/bdd.759
   Schiess S, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600886
   Schulz M, 2005, CANCER EPIDEM BIOMAR, V14, P2531, DOI 10.1158/1055-9965.EPI-05-0159
   Seo HA, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/184598
   Seo MS, 2016, PLANT MOL BIOL, V90, P503, DOI 10.1007/s11103-016-0437-z
   Serhan CN, 2011, CHEM REV, V111, P5922, DOI 10.1021/cr100396c
   Shan YJ, 2013, J NUTR BIOCHEM, V24, P1062, DOI 10.1016/j.jnutbio.2012.08.004
   Shapiro TA, 1998, CANCER EPIDEM BIOMAR, V7, P1091
   Sharma R, 2018, ACS OMEGA, V3, P8553, DOI 10.1021/acsomega.8b01088
   Siervo M, 2014, PUBLIC HEALTH NUTR, V17, P587, DOI 10.1017/S1368980013000141
   Singh AV, 2004, CARCINOGENESIS, V25, P83, DOI 10.1093/carcin/bgg178
   Singh D, 2020, LIFE SCI, V241, DOI 10.1016/j.lfs.2019.117061
   Singh-Gupta V, 2012, CANCER LETT, V318, P86, DOI 10.1016/j.canlet.2011.12.006
   Singhal S, 2005, CLIN CANCER RES, V11, P3974, DOI 10.1158/1078-0432.CCR-04-2661
   Slaby O, 2013, NUTR CANCER, V65, P247, DOI 10.1080/01635581.2013.756530
   Smith TK, 2004, CARCINOGENESIS, V25, P1409, DOI 10.1093/carcin/bgh149
   Song LJ, 2007, FOOD CHEM TOXICOL, V45, P216, DOI 10.1016/j.fct.2006.07.021
   Sorensen JC, 2016, J FUNCT FOODS, V24, P450, DOI 10.1016/j.jff.2016.04.023
   Soundararajan P, 2018, MOLECULES, V23, DOI 10.3390/molecules23112983
   Spitz MR, 2000, CANCER EPIDEM BIOMAR, V9, P1017
   Srour B, 2019, BMJ-BRIT MED J, V365, DOI 10.1136/bmj.l1451
   Steele EM, 2019, PREV MED, V125, P40, DOI 10.1016/j.ypmed.2019.05.004
   Stewart ZA, 2003, TRENDS PHARMACOL SCI, V24, P139, DOI 10.1016/S0165-6147(03)00026-9
   Strissel KJ, 2007, DIABETES, V56, P2910, DOI 10.2337/db07-0767
   Sturm C, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18091890
   Su ZY, 2014, CANCER PREV RES, V7, P319, DOI 10.1158/1940-6207.CAPR-13-0313-T
   Szaefer H, 2012, NUTR CANCER, V64, P879, DOI 10.1080/01635581.2012.690928
   Tang L, 2006, MOL CANCER THER, V5, P935, DOI 10.1158/1535-7163.MCT-05-0476
   Tang L, 2004, J NUTR, V134, P2004, DOI 10.1093/jn/134.8.2004
   Tanii H, 2017, J OCCUP HEALTH, V59, P104, DOI 10.1539/joh.16-0147-RA
   López-Chillón MT, 2019, CLIN NUTR, V38, P745, DOI 10.1016/j.clnu.2018.03.006
   Thejass P, 2007, INTEGR CANCER THER, V6, P389, DOI 10.1177/1534735407309084
   Thomson CA, 2016, NUTR REV, V74, P432, DOI 10.1093/nutrit/nuw010
   Trachootham D, 2008, BLOOD, V112, P1912, DOI 10.1182/blood-2008-04-149815
   Trayhurn P, 2005, ENDOCRINOLOGY, V146, P1003, DOI 10.1210/en.2004-1597
   van Gils CH, 2005, JAMA-J AM MED ASSOC, V293, P183, DOI 10.1001/jama.293.2.183
   Vasileva LV, 2020, PHARMACOL RES, V156, DOI 10.1016/j.phrs.2020.104760
   Virtue S, 2010, BBA-MOL CELL BIOL L, V1801, P338, DOI 10.1016/j.bbalip.2009.12.006
   Visanji JM, 2004, J NUTR, V134, P3121, DOI 10.1093/jn/134.11.3121
   Wang DX, 2017, ACTA PHARMACOL SIN, V38, P241, DOI 10.1038/aps.2016.122
   Wang LG, 2008, INT J ONCOL, V33, P375, DOI 10.3892/ijo_00000018
   Wang XH, 2009, BIOCHEM PHARMACOL, V78, P261, DOI 10.1016/j.bcp.2009.04.010
   Wang Y, 2009, INT J OBESITY, V33, P621, DOI 10.1038/ijo.2009.45
   Wang YT, 2014, MOL MED REP, V10, P543, DOI 10.3892/mmr.2014.2167
   Wong CP, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0086787
   World Health Organisation, 2018, Noncommunicable diseases Internet. Fact sheets, P1
   World Obesity Federation, OB
   Wu HZ, 2007, CIRCULATION, V115, P1029, DOI 10.1161/CIRCULATIONAHA.106.638379
   Wu TY, 2013, AAPS J, V15, P864, DOI 10.1208/s12248-013-9493-3
   Wu YF, 2015, J FUNCT FOODS, V18, P182, DOI 10.1016/j.jff.2015.07.002
   Xiao D, 2003, CARCINOGENESIS, V24, P891, DOI 10.1093/carcin/bgg023
   Xiao D, 2004, MOL CANCER THER, V3, P567
   Xiao D, 2002, CANCER RES, V62, P3615
   Xiao D, 2007, CANCER RES, V67, P2239, DOI 10.1158/0008-5472.CAN-06-3645
   Xu CJ, 2006, MOL CANCER THER, V5, P1918, DOI 10.1158/1535-7163.MCT-05-0497
   Xu CJ, 2006, CARCINOGENESIS, V27, P437, DOI 10.1093/carcin/bgi251
   Xu HN, 2018, AM FAM PHYSICIAN, V98, P590
   Xu L, 2018, ADIPOCYTE, V7, P218, DOI 10.1080/21623945.2018.1474669
   Yagi M, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0206748
   Yan SF, 2003, CIRC RES, V93, P1159, DOI 10.1161/01.RES.0000103862.26506.3D
   Yang H, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030758
   Yang H, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201700119
   Yao AJ, 2015, BIOCHEM BIOPH RES CO, V465, P696, DOI 10.1016/j.bbrc.2015.08.049
   Ye LX, 2002, CLIN CHIM ACTA, V316, P43, DOI 10.1016/S0009-8981(01)00727-6
   Yehuda H, 2012, INFLAMM RES, V61, P735, DOI 10.1007/s00011-012-0465-3
   Yoshigae Y, 2013, DRUG METAB DISPOS, V41, P858, DOI 10.1124/dmd.112.050609
   Yuan GF, 2009, J ZHEJIANG UNIV-SC B, V10, P580, DOI 10.1631/jzus.B0920051
   Yuan JM, 2016, CANCER PREV RES, V9, P598, DOI 10.1158/1940-6207.CAPR-16-0032
   Zhang CY, 2016, MOL NUTR FOOD RES, V60, P1427, DOI 10.1002/mnfr.201500918
   Zhang CY, 2013, BIOCHEM PHARMACOL, V85, P1398, DOI 10.1016/j.bcp.2013.02.010
   Zhang RF, 2006, J NUTR, V136, P2728, DOI 10.1093/jn/136.11.2728
   Zhang YS, 2001, CARCINOGENESIS, V22, P425, DOI 10.1093/carcin/22.3.425
   Zhang YS, 2003, MOL CANCER THER, V2, P1045
   Zhang YS, 2002, BIOCHEM J, V364, P301, DOI 10.1042/bj3640301
   Zhang YS, 2000, CARCINOGENESIS, V21, P1175, DOI 10.1093/carcin/21.6.1175
   Zhang ZG, 2015, REV ENDOCR METAB DIS, V16, P35, DOI 10.1007/s11154-014-9305-9
   Zhao B, 2001, CANCER EPIDEM BIOMAR, V10, P1063
   Zhou YY, 2020, LIFE SCI, V243, DOI 10.1016/j.lfs.2020.117291
NR 282
TC 84
Z9 87
U1 1
U2 34
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD SEP 2
PY 2020
VL 7
AR 111
DI 10.3389/fnut.2020.00111
PG 22
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA NS8GH
UT WOS:000572493800001
PM 32984393
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Song, CF
   Tay, PKC
   Gwee, X
   Wee, SL
   Ng, TP
AF Song, Cai Feng
   Tay, Peter Kay Chai
   Gwee, Xinyi
   Wee, Shiou Liang
   Ng, Tze Pin
TI Happy people live longer because they are healthy people
SO BMC GERIATRICS
LA English
DT Article
DE Happiness; Mortality; Positive affect; Longevity; Well-being
ID MILD COGNITIVE IMPAIRMENT; METABOLIC SYNDROME; FOLLOW-UP; ALL-CAUSE;
   MORTALITY; HAPPINESS; LIFE
AB ObjectivesHigher levels of happiness are associated with longer life expectancy. Our study assessed the extent to which various factors explain the protective effect of happiness on all-cause mortality risk, and whether the association differs between older men and women.MethodsUsing data from the Singapore Longitudinal Aging Studies (N = 6073) of community-dwelling older adults aged & GE; 55 years, we analyzed the association of baseline Likert score of happiness (1 = very sad to 5 = very happy) and mortality from mean 11.7 years of follow up. Cox regression models were used to assess the extent to which confounding risk factors attenuated the hazard ratio of association in the whole sample and sex-stratified analyses.ResultsHappiness was significantly associated with lower mortality (p < .001) adjusted for age, sex and ethnicity: HR = 0.85 per integer score and HR = 0.57 for fairly-or-very happy versus fairly-or-very sad. The HR estimate (0.90 per integer score) was modestly attenuated (33.3%) in models that included socio-demographic and support, lifestyle or physical health and functioning factor, but remained statistically significant. The HR estimate (0.94 per integer score) was substantially attenuated (60%) and was insignificant in the model that included psychological health and functioning. Including all co-varying factors in the model resulted in statistically insignificant HR estimate (1.04 per integer score). Similar results were obtained for HR estimates for fairly-to-very happy versus fairly-to- very sad).DiscussionMuch of the association between happiness and increased life expectancy could be explained by socio-demographic, lifestyle, health and functioning factors, and especially psychological health and functioning factors.
C1 [Song, Cai Feng; Tay, Peter Kay Chai; Wee, Shiou Liang] Singapore Inst Technol, Hlth & Social Sci, 10 Dover Dr, Singapore 138683, Singapore.
   [Gwee, Xinyi; Ng, Tze Pin] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Singapore, Singapore.
C3 Singapore Institute of Technology; National University of Singapore
RP Wee, SL (corresponding author), Singapore Inst Technol, Hlth & Social Sci, 10 Dover Dr, Singapore 138683, Singapore.
EM weeshioulang@gmail.com
RI Wee, Shiou-Liang/H-7115-2019
OI Wee, Shiou-Liang/0000-0002-7853-4112
CR Abdel-Khalek AM, 2006, SOC BEHAV PERSONAL, V34, P139, DOI 10.2224/sbp.2006.34.2.139
   Barger SD, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2019-031776
   Boehm JK, 2012, PSYCHOL BULL, V138, P655, DOI 10.1037/a0027448
   Chei CL, 2018, AGE AGEING, V47, P860, DOI 10.1093/ageing/afy128
   Cheong CY, 2021, AGING-US, V13, P25038, DOI 10.18632/aging.203756
   DIENER E, 1984, PSYCHOL BULL, V95, P542, DOI 10.1037/0033-2909.95.3.542
   Diener E., 2009, The Oxford handbook of positive psychology, V2nd
   Diener E, 2017, APPL PSYCHOL-HLTH WE, V9, P133, DOI 10.1111/aphw.12090
   Diener E, 2011, APPL PSYCHOL-HLTH WE, V3, P1, DOI 10.1111/j.1758-0854.2010.01045.x
   Feng L, 2013, J ALZHEIMERS DIS, V34, P649, DOI 10.3233/JAD-121885
   Gana K, 2016, J PSYCHOSOM RES, V85, P28, DOI 10.1016/j.jpsychores.2016.04.004
   Giltay EJ, 2004, ARCH GEN PSYCHIAT, V61, P1126, DOI 10.1001/archpsyc.61.11.1126
   Härkänen T, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2019-033741
   Jovanovic V, 2020, APPL RES QUAL LIFE, V15, P675, DOI 10.1007/s11482-018-9680-6
   Kimm H, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-54
   Koivumaa-Honkanen H, 2000, AM J EPIDEMIOL, V152, P983, DOI 10.1093/aje/152.10.983
   Koopmans TA, 2010, J HAPPINESS STUD, V11, P113, DOI 10.1007/s10902-008-9127-0
   Lacruz ME, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-579
   Lawrence EM, 2015, SOC SCI MED, V145, P115, DOI 10.1016/j.socscimed.2015.09.020
   Liu B, 2016, LANCET, V387, P874, DOI 10.1016/S0140-6736(15)01087-9
   Lu L., 2004, Journal of Happiness Studies, V5, P269, DOI DOI 10.1007/S10902-004-8789-5
   Martín-María N, 2017, PSYCHOSOM MED, V79, P565, DOI 10.1097/PSY.0000000000000444
   Mitnitski Arnold B, 2002, BMC Geriatr, V2, P1
   Nabi H, 2008, BMJ-BRIT MED J, V337, DOI 10.1136/bmj.a118
   Ng TP, 2016, JAMA NEUROL, V73, P456, DOI 10.1001/jamaneurol.2015.4899
   Ngoo YT, 2015, SOC INDIC RES, V124, P141, DOI 10.1007/s11205-014-0772-x
   Niti M, 2008, INT PSYCHOGERIATR, V20, P237, DOI 10.1017/S1041610207006655
   Nyunt MSZ, 2009, AGING MENT HEALTH, V13, P376, DOI 10.1080/13607860902861027
   Ostir GV, 2000, J AM GERIATR SOC, V48, P473, DOI 10.1111/j.1532-5415.2000.tb04991.x
   Pressman SD, 2005, PSYCHOL BULL, V131, P925, DOI 10.1037/0033-2909.131.6.925
   Rockwood K, 2005, CAN MED ASSOC J, V173, P489, DOI 10.1503/cmaj.050051
   Searle Samuel D, 2008, BMC Geriatr, V8, P24, DOI 10.1186/1471-2318-8-24
   SHEIKH J I, 1986, Clinical Gerontologist, V5, P165
   Shirai K, 2009, CIRCULATION, V120, P956, DOI 10.1161/CIRCULATIONAHA.108.834176
   Sin NL, 2016, CURR CARDIOL REP, V18, DOI 10.1007/s11886-016-0792-z
   Solé-Auró A, 2018, EUR J PUBLIC HEALTH, V28, P847, DOI 10.1093/eurpub/cky070
   Tamosiunas A, 2019, SOC PSYCH PSYCH EPID, V54, P803, DOI 10.1007/s00127-019-01657-2
   Trudel-Fitzgerald C, 2019, PREV MED, V126, DOI 10.1016/j.ypmed.2019.105754
   Wei K, 2017, J AM MED DIR ASSOC, V18, P1019, DOI 10.1016/j.jamda.2017.06.017
   Willroth EC, 2020, PSYCHOSOM MED, V82, P650, DOI 10.1097/PSY.0000000000000832
   Xu G., 2021, China Popul Dev Stud, V5, P1, DOI [10.1007/s42379-021-00076-8, DOI 10.1007/S42379-021-00076-8]
   Xu JP, 2010, HEALTH PSYCHOL, V29, P9, DOI 10.1037/a0016767
   Yang D., 2017, Open Journal of Social Sciences, V5, P181, DOI DOI 10.4236/JSS.2017.511013
   Zaninotto P, 2019, JAMA NETW OPEN, V2, DOI 10.1001/jamanetworkopen.2019.6870
   Zaninotto P, 2016, BMJ-BRIT MED J, V355, DOI 10.1136/bmj.i6267
NR 45
TC 7
Z9 7
U1 3
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2318
J9 BMC GERIATR
JI BMC Geriatr.
PD JUL 18
PY 2023
VL 23
IS 1
AR 440
DI 10.1186/s12877-023-04030-w
PG 10
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA M6MN9
UT WOS:001031338700002
PM 37464330
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, YH
   Ryu, S
   Nam, HJ
   Kim, M
   Jhon, M
   Lee, JY
   Kim, JM
   Shin, MH
   Chung, YC
   Kim, SW
AF Kim, Young-Hyuk
   Ryu, Seunghyong
   Nam, Hee-Jung
   Kim, Mina
   Jhon, Min
   Lee, Ju-Yeon
   Kim, Jae-Min
   Shin, Min Ho
   Chung, Young-Chul
   Kim, Sung-Wan
TI The Psychology of Food Cravings in Patients With First-Episode Psychosis
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE weight gain; food craving; schizophrenia; First-Episode Psychosis (FEP);
   stress; depression
ID BODY-MASS INDEX; QUALITY-OF-LIFE; WEIGHT-GAIN; METABOLIC SYNDROME;
   CHRONIC STRESS; NAIVE SCHIZOPHRENIA; GENDER DIFFERENCES; PERCEIVED
   STRESS; PHYSICAL HEALTH; SOCIAL SUPPORT
AB Objectives: Food cravings may cause weight gain in patients with schizophrenia. This study investigated psychological characteristics associated with food cravings in patients with first-episode psychosis.
   Methods: This study analyzed data from a clinical cohort of first-episode psychosis patients taking antipsychotics for 3 months or less. The strength of food cravings was measured using the General Food Cravings Questionnaire-Trait (G-FCQ-T). Psychological characteristics and psychiatric symptoms were investigated with the Positive and Negative Symptom Scale (PANSS), Calgary Depression Scale for Schizophrenia (CDSS), Social and Occupational Functioning Assessment Scale, Rosenberg Self-Esteem Scale (RSES), and Perceived Stress Scale (PSS). Clinical characteristics were compared according to significant weight gain (>= 10% increase in body weight compared to baseline) over 3 months. Associations between the G-FCQ-T and other psychiatric scales were investigated. We conducted sex-stratified analyses.
   Results: In total, 182 patients (78 males and 104 females) with first-episode psychosis were enrolled in this study. In females, the G-FCQ-T total score at baseline was associated with baseline body weight and significant weight gain over 3 months. The PSS scales were significantly associated the G-FCQ-T total and all subscale scores in female participants. Scores on the RSES and CDSS were significantly associated with the G-FCQ-T total score and with the preoccupation and loss of control subscale scores. The PANSS negative and general subscales were significantly associated with the positive outcome expectancy and loss of control subscales of the G-FCQ-T, respectively. In males, the only significant association was between the loss of control subscale and RSES scores. Linear regression analysis showed significant associations of PSS scores with the total and all subscale scores of the G-FCQ-T despite the loss of significance for other variables.
   Conclusion: These results indicate that the food cravings in patients with first-episode psychosis, which were associated with weight gain, were influenced by perceived stress in females. To reduce food cravings in female patients with schizophrenia, interventions aimed at perceived stress should be considered.
C1 [Kim, Young-Hyuk; Ryu, Seunghyong; Jhon, Min; Lee, Ju-Yeon; Kim, Jae-Min; Kim, Sung-Wan] Chonnam Natl Univ, Dept Psychiat, Med Sch, Gwangju, South Korea.
   [Nam, Hee-Jung] Seoul Med Ctr, Dept Psychiat, Seoul, South Korea.
   [Kim, Mina; Lee, Ju-Yeon; Kim, Sung-Wan] Gwangju Mental Hlth & Welf Commiss, Gwangju, South Korea.
   [Kim, Mina] Chonnam Natl Univ, Grad Sch, Dept Nursing, Gwangju, South Korea.
   [Shin, Min Ho] Chonnam Natl Univ, Dept Prevent Med, Med Sch, Hwasun, South Korea.
   [Chung, Young-Chul] Chonbuk Natl Univ, Dept Psychiat, Med Sch, Jeonju, South Korea.
C3 Chonnam National University; Seoul Medical Center; Chonnam National
   University; Chonnam National University; Jeonbuk National University
RP Kim, SW (corresponding author), Chonnam Natl Univ, Dept Psychiat, Med Sch, Gwangju, South Korea.; Kim, SW (corresponding author), Gwangju Mental Hlth & Welf Commiss, Gwangju, South Korea.
EM swkim@chonnam.ac.kr
RI Chung, Young/AAB-8242-2022; Lee, Jung-Seok/L-6826-2019
FU Korean Mental Health Technology R&D Project, Ministry of Health &
   Welfare, Republic of Korea [HL19C0015]; Basic Science Research Program
   through the National Research Foundation of Korea [NRF-2017R1A2B4010830]
FX YY This study was supported by a grant of the Korean Mental Health
   Technology R&D Project, Ministry of Health & Welfare, Republic of Korea
   (HL19C0015) and a grant from the Basic Science Research Program through
   the National Research Foundation of Korea (NRF-2017R1A2B4010830). The
   funder had no role in study design; in the writing of the report; or in
   the decision to submit the paper for publication.
CR Adam TC, 2007, PHYSIOL BEHAV, V91, P449, DOI 10.1016/j.physbeh.2007.04.011
   ADDINGTON D, 1990, SCHIZOPHR RES, V3, P247, DOI 10.1016/0920-9964(90)90005-R
   Allison DB, 2003, PSYCHIAT SERV, V54, P565, DOI 10.1176/appi.ps.54.4.565
   Allison DB, 1999, AM J PSYCHIAT, V156, P1686
   Association AP, 2013, Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
   Tran BT, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-016-3936-6
   Boswell RG, 2016, OBES REV, V17, P159, DOI 10.1111/obr.12354
   Carter JD, 2000, J AFFECT DISORDERS, V61, P59, DOI 10.1016/S0165-0327(00)00151-8
   Cartwright M, 2003, HEALTH PSYCHOL, V22, P362, DOI 10.1037/0278-6133.22.4.362
   Catapano Lisa, 2004, Australas Psychiatry, V12, P23, DOI 10.1046/j.1039-8562.2003.02054.x
   Cepeda-Benito A, 2000, BEHAV THER, V31, P151, DOI 10.1016/S0005-7894(00)80009-X
   Cohen D, 2011, NEUROPSYCHOPHARMACOL, V36, P2368, DOI 10.1038/npp.2011.94
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Correll CU, 2011, TRENDS MOL MED, V17, P97, DOI 10.1016/j.molmed.2010.10.010
   Correll CU, 2009, JAMA-J AM MED ASSOC, V302, P1765, DOI 10.1001/jama.2009.1549
   Correll CU, 2006, J CLIN PSYCHIAT, V67, P160, DOI 10.4088/JCP.v67n0122
   Dallman MF, 2005, BRAIN BEHAV IMMUN, V19, P275, DOI 10.1016/j.bbi.2004.11.004
   Dallman MF, 2003, P NATL ACAD SCI USA, V100, P11696, DOI 10.1073/pnas.1934666100
   Dayabandara M, 2017, NEUROPSYCH DIS TREAT, V13, DOI 10.2147/NDT.S113099
   De Hert MA, 2006, SCHIZOPHR RES, V83, P87, DOI 10.1016/j.schres.2005.12.855
   De Hert M, 2009, WORLD PSYCHIATRY, V8, P15
   El Ansari W, 2014, CENT EUR J PUBL HEAL, V22, P90, DOI 10.21101/cejph.a3941
   Emsley R, 2003, SCHIZOPHR RES, V61, P47, DOI 10.1016/S0920-9964(02)00302-X
   Fairburn C.G., 1986, HDB EATING DISORDERS, P389
   Foster MT, 2009, ENDOCRINOLOGY, V150, P2325, DOI 10.1210/en.2008-1426
   Fowles ER, 2012, J ACAD NUTR DIET, V112, P1619, DOI 10.1016/j.jand.2012.07.002
   GOLDMAN HH, 1992, AM J PSYCHIAT, V149, P1148
   Green AI, 2000, GEN HOSP PSYCHIAT, V22, P224, DOI 10.1016/S0163-8343(00)00081-5
   Haynes Charlotte, 2003, Eat Behav, V4, P369, DOI 10.1016/j.eatbeh.2003.07.005
   HEATHERTON TF, 1991, PSYCHOL BULL, V110, P86, DOI 10.1037/0033-2909.110.1.86
   Jihae Noh, 2008, Korean Journal of Clinical Psychology, V27, P1039, DOI 10.15842/kjcp.2008.27.4.015
   Jo A, 2021, EARLY INTERV PSYCHIA, V15, P889, DOI 10.1111/eip.13029
   Kim SW, 2019, CLIN PSYCHOPHARM NEU, V17, P279, DOI 10.9758/cpn.2019.17.2.279
   Ko YK, 2013, CLIN PSYCHOPHARM NEU, V11, P80, DOI 10.9758/cpn.2013.11.2.80
   Kurzthaler I, 2001, J CLIN PSYCHIAT, V62, P32
   Lacey J., 1986, Current approaches: Bulimia nervosa, P17
   Lafay L, 2001, INT J EAT DISORDER, V29, P195, DOI 10.1002/1098-108X(200103)29:2<195::AID-EAT1009>3.0.CO;2-N
   Le Fevre PD, 2001, SCOT MED J, V46, P11
   Lee JS, 2017, PSYCHIAT INVEST, V14, P44, DOI 10.4306/pi.2017.14.1.44
   Liu CH, 2007, PHYSIOL BEHAV, V92, P748, DOI 10.1016/j.physbeh.2007.05.068
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Majzoub JA, 2006, EUR J ENDOCRINOL, V155, pS71, DOI 10.1530/eje.1.02247
   MARTI O, 1994, PHYSIOL BEHAV, V55, P747, DOI 10.1016/0031-9384(94)90055-8
   Meule A, 2017, EAT BEHAV, V26, P66, DOI 10.1016/j.eatbeh.2017.01.012
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Myers CA, 2018, CURR OPIN ENDOCRINOL, V25, P298, DOI 10.1097/MED.0000000000000434
   Newcomer JW, 2006, CAN J PSYCHIAT, V51, P480, DOI 10.1177/070674370605100803
   Nielsen J, 2010, NEUROPSYCHOPHARMACOL, V35, P1997, DOI 10.1038/npp.2010.78
   Nijs IMT, 2007, APPETITE, V49, P38, DOI 10.1016/j.appet.2006.11.001
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Osborn DPJ, 2001, WESTERN J MED, V175, P329, DOI 10.1136/ewjm.175.5.329
   Paans NPG, 2019, APPETITE, V134, P103, DOI 10.1016/j.appet.2018.12.030
   Pendleton V R, 2001, Eat Disord, V9, P351, DOI 10.1080/106402601753454912
   Provencher V, 2003, OBES RES, V11, P783, DOI 10.1038/oby.2003.109
   ROBBINS TW, 1980, APPETITE, V1, P231, DOI 10.1016/S0195-6663(80)80033-X
   Roick C, 2007, SOC PSYCH PSYCH EPID, V42, P268, DOI 10.1007/s00127-007-0164-5
   Rosenberg M., 1972, SOC ADOLESCENT SELF
   Rummel-Kluge C, 2010, SCHIZOPHR RES, V123, P225, DOI 10.1016/j.schres.2010.07.012
   Sanlier N, 2016, ECOL FOOD NUTR, V55, P491, DOI 10.1080/03670244.2016.1219951
   Schimmelmann BG, 2008, J PSYCHIATR RES, V42, P982, DOI 10.1016/j.jpsychires.2007.12.001
   Schommer NC, 2003, PSYCHOSOM MED, V65, P450, DOI 10.1097/01.PSY.0000035721.12441.17
   Stambor Z., 2006, Monitor on Psychology, V37, P28, DOI DOI 10.1037/e494972006-019
   Steptoe A, 1996, J PSYCHOSOM RES, V41, P171, DOI 10.1016/0022-3999(96)00095-5
   Strassnig M, 2003, SCHIZOPHR RES, V62, P73, DOI 10.1016/S0920-9964(02)00441-3
   Tomiyama AJ, 2011, PSYCHONEUROENDOCRINO, V36, P1513, DOI 10.1016/j.psyneuen.2011.04.005
   Torres SJ, 2007, NUTRITION, V23, P887, DOI 10.1016/j.nut.2007.08.008
   Tryon MS, 2013, PHYSIOL BEHAV, V114, P32, DOI 10.1016/j.physbeh.2013.02.018
   Ulrich-Lai YM, 2007, ENDOCRINOLOGY, V148, P1823, DOI 10.1210/en.2006-1241
   Vainik U, 2019, EUR J NEUROSCI, V50, P2430, DOI 10.1111/ejn.14352
   van Strien Tatjana, 2003, Eat Behav, V3, P329, DOI 10.1016/S1471-0153(02)00092-2
   Waller G, 2000, INT J EAT DISORDER, V28, P235, DOI 10.1002/1098-108X(200009)28:2<235::AID-EAT15>3.3.CO;2-T
   Wang GJ, 2001, LANCET, V357, P354, DOI 10.1016/S0140-6736(00)03643-6
   Wardle J, 2002, STRESS AND THE HEART: PSYCHOSOCIAL PATHWAYS TO CORONARY HEART DISEASE, P124
   Wardle J, 2000, J PSYCHOSOM RES, V48, P195, DOI 10.1016/S0022-3999(00)00076-3
   Warne JP, 2009, MOL CELL ENDOCRINOL, V300, P137, DOI 10.1016/j.mce.2008.09.036
   Weiden PJ, 2004, SCHIZOPHR RES, V66, P51, DOI 10.1016/S0920-9964(02)00498-X
   Willner P, 1998, PSYCHOPHARMACOLOGY, V136, P272, DOI 10.1007/s002130050566
   Wirshing DA, 2004, J CLIN PSYCHIAT, V65, P13
   Woods SW, 2003, J CLIN PSYCHIAT, V64, P663, DOI 10.4088/JCP.v64n0607
   Yau YHC, 2013, MINERVA ENDOCRINOL, V38, P255
   Zellner DA, 2006, PHYSIOL BEHAV, V87, P789, DOI 10.1016/j.physbeh.2006.01.014
NR 81
TC 4
Z9 4
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD DEC 11
PY 2020
VL 11
AR 587486
DI 10.3389/fpsyt.2020.587486
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA PJ2HM
UT WOS:000601595800001
PM 33362604
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kapoor, A
   Sanyal, AJ
AF Kapoor, Ashwani
   Sanyal, Arun J.
TI Endoplasmic Reticulum Stress and the Unfolded Protein Response
SO CLINICS IN LIVER DISEASE
LA English
DT Article
DE Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Fatty
   liver; Unfolded protein response; ER stress; Eukaryotic initiation
   factor; Inflammation; Metabolic syndrome
ID FATTY LIVER-DISEASE; ER STRESS; TRANSCRIPTION FACTOR; MESSENGER-RNA;
   NONALCOHOLIC STEATOHEPATITIS; HEPATOCYTE APOPTOSIS; SIGNAL-TRANSDUCTION;
   CELL-SURVIVAL; DEGRADATION; ACTIVATION
AB The endoplasmic reticulum (ER) is the key cellular organelle involved in protein homoeostasis. The unfolded protein response (UPR) is a fundamental cellular process triggered by ER stress because of lack of ATP or primary ER dysfunction. The UPR is activated and dysregulated in non-alcoholic fatty liver disease (NAFLD). The UPR has been shown to be involved in both normal physiologic functions and the cellular response to a host of pathologic states. This article reviews the pathways by which the UPR unfolds and its potential role in the development and progression of NAFLD.
C1 [Kapoor, Ashwani; Sanyal, Arun J.] Virginia Commonwealth Univ, Sch Med, Div Gastroenterol Hepatol & Nutr, Dept Internal Med, Richmond, VA 23298 USA.
C3 Virginia Commonwealth University
RP Sanyal, AJ (corresponding author), Virginia Commonwealth Univ, Sch Med, Div Gastroenterol Hepatol & Nutr, Dept Internal Med, 1200 E Broad St,MCV Box 980341, Richmond, VA 23298 USA.
EM asanyal@mcvh-vcu.edu
FU National Institutes of Health [K24 DK 02755-09]
FX It was supported in part by a grant from the National Institutes of
   Health to Dr. Arun Sanyal, K24 DK 02755-09.
CR ADLER V, 1995, J BIOL CHEM, V270, P26071, DOI 10.1074/jbc.270.44.26071
   Aguirre V, 2002, J BIOL CHEM, V277, P1531, DOI 10.1074/jbc.M101521200
   ANFINSEN CB, 1973, SCIENCE, V181, P223, DOI 10.1126/science.181.4096.223
   Bertolotti A, 2000, NAT CELL BIOL, V2, P326, DOI 10.1038/35014014
   BROSTROM MA, 1995, J BIOL CHEM, V270, P4127, DOI 10.1074/jbc.270.8.4127
   Brown MS, 1997, CELL, V89, P331, DOI 10.1016/S0092-8674(00)80213-5
   Cullinan SB, 2003, MOL CELL BIOL, V23, P7198, DOI 10.1128/MCB.23.20.7198-7209.2003
   Davis RJ, 2000, CELL, V103, P239, DOI 10.1016/S0092-8674(00)00116-1
   DeVries-Seimon T, 2005, J CELL BIOL, V171, P61, DOI 10.1083/jcb.200502078
   Dinkova-Kostova AT, 2002, P NATL ACAD SCI USA, V99, P11908, DOI 10.1073/pnas.172398899
   Diraison F, 2003, DIABETES METAB, V29, P478, DOI 10.1016/S1262-3636(07)70061-7
   Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI23621
   Feldstein AE, 2003, GASTROENTEROLOGY, V125, P437, DOI 10.1016/S0016-5085(03)00907-7
   Feng B, 2003, NAT CELL BIOL, V5, P781, DOI 10.1038/ncb1035
   Gomez E, 2008, BIOCHEM J, V410, P485, DOI 10.1042/BJ20071367
   Harding HP, 2000, MOL CELL, V5, P897, DOI 10.1016/S1097-2765(00)80330-5
   Haze K, 2001, BIOCHEM J, V355, P19, DOI 10.1042/0264-6021:3550019
   Hinnebusch Alan G., 1994, Seminars in Cell Biology, V5, P417, DOI 10.1006/scel.1994.1049
   Hirao K, 2006, J BIOL CHEM, V281, P9650, DOI 10.1074/jbc.M512191200
   Horton JD, 2003, P NATL ACAD SCI USA, V100, P12027, DOI 10.1073/pnas.1534923100
   Hosokawa N, 2003, J BIOL CHEM, V278, P26287, DOI 10.1074/jbc.M303395200
   Ji C, 2007, HEPATOLOGY, V46, P1586, DOI 10.1002/hep.21854
   Kostova Z, 2007, SEMIN CELL DEV BIOL, V18, P770, DOI 10.1016/j.semcdb.2007.09.002
   Lange Y, 2008, PROG LIPID RES, V47, P319, DOI 10.1016/j.plipres.2008.03.001
   Lee AH, 2008, SCIENCE, V320, P1492, DOI 10.1126/science.1158042
   LIPPINCOTTSCHWARTZ J, 1988, CELL, V54, P209, DOI 10.1016/0092-8674(88)90553-3
   Liu CY, 2000, J BIOL CHEM, V275, P24881, DOI 10.1074/jbc.M004454200
   Marra F, 1999, J HEPATOL, V31, P1120
   Mast SW, 2005, GLYCOBIOLOGY, V15, P421, DOI 10.1093/glycob/cwi014
   Matsukawa J, 2004, J BIOCHEM, V136, P261, DOI 10.1093/jb/mvh134
   Morishima N, 2002, J BIOL CHEM, V277, P34287, DOI 10.1074/jbc.M204973200
   Nakagawa T, 2000, NATURE, V403, P98, DOI 10.1038/47513
   Novoa I, 2001, J CELL BIOL, V153, P1011, DOI 10.1083/jcb.153.5.1011
   Puri P, 2008, GASTROENTEROLOGY, V134, P568, DOI 10.1053/j.gastro.2007.10.039
   Puri P, 2007, HEPATOLOGY, V46, P1081, DOI 10.1002/hep.21763
   Ribeiro PS, 2004, AM J GASTROENTEROL, V99, P1708, DOI 10.1111/j.1572-0241.2004.40009.x
   Sanyal AJ, 2001, GASTROENTEROLOGY, V120, P1183, DOI 10.1053/gast.2001.23256
   Schattenberg JM, 2006, HEPATOLOGY, V43, P163, DOI 10.1002/hep.20999
   Scheuner D, 2001, MOL CELL, V7, P1165, DOI 10.1016/S1097-2765(01)00265-9
   Schultz JR, 2000, GENE DEV, V14, P2831, DOI 10.1101/gad.850400
   Seki S, 2005, HEPATOL RES, V33, P132, DOI 10.1016/j.hepres.2005.09.020
   Shamu Caroline E., 1994, Trends in Cell Biology, V4, P56, DOI 10.1016/0962-8924(94)90011-6
   Shimomura I, 1999, J BIOL CHEM, V274, P30028, DOI 10.1074/jbc.274.42.30028
   Stumptner C, 2001, J HEPATOL, V34, P665, DOI 10.1016/S0168-8278(00)00099-4
   Su HL, 2002, J VIROL, V76, P4162, DOI 10.1128/JVI.76.9.4162-4171.2002
   Urano F, 2000, SCIENCE, V287, P664, DOI 10.1126/science.287.5453.664
   van Huizen R, 2003, J BIOL CHEM, V278, P15558, DOI 10.1074/jbc.M212074200
   Wang D, 2006, ENDOCRINOLOGY, V147, P943, DOI 10.1210/en.2005-0570
   Wang XZ, 1998, EMBO J, V17, P5708, DOI 10.1093/emboj/17.19.5708
   Wang XZ, 1998, EMBO J, V17, P3619, DOI 10.1093/emboj/17.13.3619
   Weston CR, 2007, CURR OPIN CELL BIOL, V19, P142, DOI 10.1016/j.ceb.2007.02.001
   White MF, 2003, SCIENCE, V302, P1710, DOI 10.1126/science.1092952
   Wasef SZY, 2006, AM J PHYSIOL-ENDOC M, V291, pE1274, DOI 10.1052/ajpendo.00117.2006
   Yan W, 2002, P NATL ACAD SCI USA, V99, P15920, DOI 10.1073/pnas.252341799
   Ye J, 2000, MOL CELL, V6, P1355, DOI 10.1016/S1097-2765(00)00133-7
   Yoshida H, 2001, CELL, V107, P881, DOI 10.1016/S0092-8674(01)00611-0
   Yoshida H, 2000, MOL CELL BIOL, V20, P6755, DOI 10.1128/MCB.20.18.6755-6767.2000
   Yoshida H, 2007, ANTIOXID REDOX SIGN, V9, P2323, DOI 10.1089/ars.2007.1800
NR 58
TC 85
Z9 98
U1 1
U2 17
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1089-3261
EI 1557-8224
J9 CLIN LIVER DIS
JI Clin. Liver Dis.
PD NOV
PY 2009
VL 13
IS 4
BP 581
EP +
DI 10.1016/j.cld.2009.07.004
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 514JJ
UT WOS:000271390100006
PM 19818306
DA 2025-06-11
ER

PT S
AU Stadler, K
AF Stadler, Krisztian
BE Ahmad, SI
TI OXIDATIVE STRESS IN DIABETES
SO DIABETES: AN OLD DISEASE, A NEW INSIGHT
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
ID POLY(ADP-RIBOSE) POLYMERASE ACTIVATION; PROTEIN-KINASE-C; INDUCED
   INSULIN-RESISTANCE; ALDOSE REDUCTASE INHIBITION; NITRIC-OXIDE SYNTHASE;
   PEROXYNITRITE DECOMPOSITION CATALYST; ENZYME GENE-EXPRESSION;
   FREE-RADICAL FORMATION; MITOCHONDRIAL DYSFUNCTION; NITROSATIVE STRESS
AB Oxidative stress and diabetes, both Type I and Type 2 as well as their related conditions have been extensively studied. As diabetes, obesity and metabolic syndrome have reached at epidemic levels, there is a huge need and effort to understand the detailed molecular mechanisms of the possible redo x imbalance, underlying the cause of pathology and progression of the disease. These studies provide new insights at cellular and subcellular levels to design effective clinical interventions. This chapter is intended to emphasize the latest knowledge and current evidence on the role of oxidative stress in diabetes as well as to discuss some key questions that are currently under discussion
C1 Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center
RP Stadler, K (corresponding author), Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM krisztian.stadler@pbrc.edu
RI Stadler, Krisztian/N-1992-2017
CR Abordo EA, 1997, IMMUNOL LETT, V58, P139, DOI 10.1016/S0165-2478(97)00080-1
   Anderson EJ., 2009, J CLIN INVEST
   [Anonymous], FASEB J
   [Anonymous], LANCET, V352, P837, DOI DOI 10.1016/S0140-6736(98)07019-6
   [Anonymous], DIABETES
   Baynes JW, 1999, DIABETES, V48, P1, DOI 10.2337/diabetes.48.1.1
   BAYNES JW, 1991, DIABETES, V40, P405, DOI 10.2337/diabetes.40.4.405
   BECKMAN JS, 1990, P NATL ACAD SCI USA, V87, P1620, DOI 10.1073/pnas.87.4.1620
   Beckman JS, 1996, CHEM RES TOXICOL, V9, P836, DOI 10.1021/tx9501445
   Bonini MG, 2007, FREE RADICAL BIO MED, V42, P530, DOI 10.1016/j.freeradbiomed.2006.11.019
   Bonini MG, 2006, FREE RADICAL BIO MED, V40, P968, DOI 10.1016/j.freeradbiomed.2005.10.042
   Bonnard C, 2008, J CLIN INVEST, V118, P789, DOI 10.1172/JCI32601
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Brownlee M, 2005, DIABETES, V54, P1615, DOI 10.2337/diabetes.54.6.1615
   Cassina AM, 2000, J BIOL CHEM, V275, P21409, DOI 10.1074/jbc.M909978199
   Cassina P, 2008, J NEUROSCI, V28, P4115, DOI 10.1523/JNEUROSCI.5308-07.2008
   CERIELLO A, 1993, DIABETOLOGIA, V36, P265, DOI 10.1007/BF00399961
   CERIELLO A, 1992, DIABETIC MED, V9, P297, DOI 10.1111/j.1464-5491.1992.tb01783.x
   Ceriello A, 2002, DIABETES CARE, V25, P1439, DOI 10.2337/diacare.25.8.1439
   Ceriello A, 2002, DIABETES, V51, P1076, DOI 10.2337/diabetes.51.4.1076
   Chatterjee S, 2009, FREE RADICAL BIO MED, V46, P454, DOI 10.1016/j.freeradbiomed.2008.10.046
   Curtis R, 2005, PATIENT EDUC COUNS, V59, P192, DOI 10.1016/j.pec.2004.10.015
   Demozay D, 2008, DIABETES, V57, P1216, DOI 10.2337/db07-0389
   Detweiler CD, 2002, FREE RADICAL BIO MED, V33, P364, DOI 10.1016/S0891-5849(02)00895-X
   Drel VR, 2007, EUR J PHARMACOL, V569, P48, DOI 10.1016/j.ejphar.2007.05.055
   Drel VR, 2006, FREE RADICAL BIO MED, V40, P1454, DOI 10.1016/j.freeradbiomed.2005.12.034
   Du XL, 2000, P NATL ACAD SCI USA, V97, P12222, DOI 10.1073/pnas.97.22.12222
   Du XL, 2003, J CLIN INVEST, V112, P1049, DOI 10.1172/JCI200318127
   Du YP, 2002, J NEUROCHEM, V80, P771, DOI 10.1046/j.0022-3042.2001.00737.x
   DYER DG, 1993, J CLIN INVEST, V91, P2463, DOI 10.1172/JCI116481
   Eizirik DL, 2001, DIABETOLOGIA, V44, P2115, DOI 10.1007/s001250100021
   Elizalde M, 2000, J LIPID RES, V41, P1244
   ENGERMAN RL, 1994, DIABETOLOGIA, V37, P141, DOI 10.1007/s001250050084
   ESTERBAUER H, 1991, FREE RADICAL BIO MED, V11, P81, DOI 10.1016/0891-5849(91)90192-6
   Evans JL, 2003, DIABETES, V52, P1, DOI 10.2337/diabetes.52.1.1
   Evans JL, 2002, ENDOCR REV, V23, P599, DOI 10.1210/er.2001-0039
   Fujimoto M, 2005, DIABETES, V54, P1340, DOI 10.2337/diabetes.54.5.1340
   GABBAY KH, 1966, SCIENCE, V151, P209, DOI 10.1126/science.151.3707.209
   GIARDINO I, 1994, J CLIN INVEST, V94, P110, DOI 10.1172/JCI117296
   Grimsrud PA, 2007, MOL CELL PROTEOMICS, V6, P624, DOI 10.1074/mcp.M600120-MCP200
   Ha HC, 1999, P NATL ACAD SCI USA, V96, P13978, DOI 10.1073/pnas.96.24.13978
   Haffner SM, 1999, AM J CARDIOL, V84, p11J
   Hancock CR, 2008, P NATL ACAD SCI USA, V105, P7815, DOI 10.1073/pnas.0802057105
   Hanley AJG, 2002, DIABETES CARE, V25, P1177, DOI 10.2337/diacare.25.7.1177
   Hodara R, 2004, J BIOL CHEM, V279, P47746, DOI 10.1074/jbc.M408906200
   Hoehn KL, 2009, P NATL ACAD SCI USA, V106, P17787, DOI 10.1073/pnas.0902380106
   Ilnytska O, 2006, DIABETES, V55, P1686, DOI 10.2337/db06-0067
   Inoguchi T, 2000, DIABETES, V49, P1939, DOI 10.2337/diabetes.49.11.1939
   Ischiropoulos H, 2003, BIOCHEM BIOPH RES CO, V305, P776, DOI 10.1016/S0006-291X(03)00814-3
   Ischiropoulos H, 1998, ARCH BIOCHEM BIOPHYS, V356, P1, DOI 10.1006/abbi.1998.0755
   KNECHT KT, 1993, ARCH BIOCHEM BIOPHYS, V303, P185, DOI 10.1006/abbi.1993.1272
   KNECHT KT, 1988, DRUG METAB DISPOS, V16, P813
   Korshunov SS, 1997, FEBS LETT, V416, P15, DOI 10.1016/S0014-5793(97)01159-9
   Koves TR, 2008, CELL METAB, V7, P45, DOI 10.1016/j.cmet.2007.10.013
   Kowluru RA, 2005, ANTIOXID REDOX SIGN, V7, P1581, DOI 10.1089/ars.2005.7.1581
   Kowluru RA, 2007, EXP DIABETES RES, DOI 10.1155/2007/43603
   Koya D, 1997, J CLIN INVEST, V100, P115, DOI 10.1172/JCI119503
   Koya D, 1998, DIABETES, V47, P859, DOI 10.2337/diabetes.47.6.859
   Krebs M, 2004, CURR MED CHEM, V11, P901, DOI 10.2174/0929867043455620
   LAI EK, 1979, BIOCHEM PHARMACOL, V28, P2231, DOI 10.1016/0006-2952(79)90212-0
   Lee AYW, 1999, FASEB J, V13, P23, DOI 10.1096/fasebj.13.1.23
   Lee HY, 2010, CELL METAB, V12, P668, DOI 10.1016/j.cmet.2010.11.004
   Lenzen S, 1996, FREE RADICAL BIO MED, V20, P463, DOI 10.1016/0891-5849(96)02051-5
   Lowell BB, 2005, SCIENCE, V307, P384, DOI 10.1126/science.1104343
   Mabley Jon G., 2005, Current Vascular Pharmacology, V3, P247, DOI 10.2174/1570161054368571
   MacMillanCrow LA, 1996, P NATL ACAD SCI USA, V93, P11853, DOI 10.1073/pnas.93.21.11853
   Marette A, 2003, INT J OBESITY, V27, pS46, DOI 10.1038/sj.ijo.0802500
   Marette A, 2002, CURR OPIN CLIN NUTR, V5, P377, DOI 10.1097/00075197-200207000-00005
   MARSHALL S, 1991, J BIOL CHEM, V266, P4706
   Mason RP, 2004, FREE RADICAL BIO MED, V36, P1214, DOI 10.1016/j.freeradbiomed.2004.02.077
   Masters SL, 2010, NAT IMMUNOL, V11, P897, DOI 10.1038/ni.1935
   McClain DA, 2002, J DIABETES COMPLICAT, V16, P72, DOI 10.1016/S1056-8727(01)00188-X
   McGarry JD, 2002, DIABETES, V51, P7, DOI 10.2337/diabetes.51.1.7
   MCLELLAN AC, 1994, CLIN SCI, V87, P21, DOI 10.1042/cs0870021
   Merényi G, 1998, CHEM RES TOXICOL, V11, P712, DOI 10.1021/tx980043h
   Muoio DM, 2006, ANNU REV BIOCHEM, V75, P367, DOI 10.1146/annurev.biochem.75.103004.142512
   Nishikawa T, 2000, NATURE, V404, P787, DOI 10.1038/35008121
   Obrosova IG, 2005, ANTIOXID REDOX SIGN, V7, P1543, DOI 10.1089/ars.2005.7.1543
   Obrosova IG, 2004, INT J MOL MED, V14, P55
   Obrosova IG, 2005, DIABETES, V54, P234, DOI 10.2337/diabetes.54.1.234
   Obrosova IG, 2005, DIABETES, V54, P3435, DOI 10.2337/diabetes.54.12.3435
   Obrosova IG, 2004, DIABETES, V53, P711, DOI 10.2337/diabetes.53.3.711
   Obrosova IG, 2007, AM J PHYSIOL-ENDOC M, V293, pE1645, DOI 10.1152/ajpendo.00479.2007
   Obrosova IG, 2009, BBA-MOL BASIS DIS, V1792, P931, DOI 10.1016/j.bbadis.2008.11.005
   Pacher P, 2005, ANTIOXID REDOX SIGN, V7, P1568, DOI 10.1089/ars.2005.7.1568
   Pacher P, 2004, J PHARMACOL EXP THER, V311, P485, DOI 10.1124/jpet.104.069658
   Pacher P, 2002, INT J MOL MED, V9, P659
   Pacher P, 2002, DIABETES, V51, P514, DOI 10.2337/diabetes.51.2.514
   Pacher P, 2007, PHYSIOL REV, V87, P315, DOI 10.1152/physrev.00029.2006
   Patti ME, 1999, DIABETES, V48, P1562, DOI 10.2337/diabetes.48.8.1562
   Perreault M, 2001, NAT MED, V7, P1138, DOI 10.1038/nm1001-1138
   Quijano C, 2001, J BIOL CHEM, V276, P11631, DOI 10.1074/jbc.M009429200
   Ramirez DC, 2005, J BIOL CHEM, V280, P27402, DOI 10.1074/jbc.M504241200
   Robertson RP, 2006, CURR OPIN PHARMACOL, V6, P615, DOI 10.1016/j.coph.2006.09.002
   Rota C, 1999, FREE RADICAL BIO MED, V27, P873, DOI 10.1016/S0891-5849(99)00137-9
   Ruggiero C, 2011, AM J PHYSIOL-ENDOC M, V300, pE1047, DOI 10.1152/ajpendo.00666.2010
   Saengsirisuwan V, 2004, AM J PHYSIOL-ENDOC M, V287, pE529, DOI 10.1152/ajpendo.00013.2004
   Sano T, 1998, DIABETOLOGIA, V41, P1355, DOI 10.1007/s001250051076
   Schroder K, 2010, SCIENCE, V327, P296, DOI 10.1126/science.1184003
   Shimabukuro M, 1998, P NATL ACAD SCI USA, V95, P2498, DOI 10.1073/pnas.95.5.2498
   Shimabukuro M, 1997, J CLIN INVEST, V100, P290, DOI 10.1172/JCI119534
   Shinohara M, 1998, J CLIN INVEST, V101, P1142, DOI 10.1172/JCI119885
   Sinha S, 2004, J BIOL CHEM, V279, P41294, DOI 10.1074/jbc.M406514200
   Stadler K, 2003, FREE RADICAL BIO MED, V35, P1240, DOI 10.1016/S0891-5849(03)00499-4
   Stadler K, 2008, FREE RADICAL BIO MED, V45, P866, DOI 10.1016/j.freeradbiomed.2008.06.023
   Stadler K, 2008, AM J PHYSIOL-ENDOC M, V295, pE456, DOI 10.1152/ajpendo.00015.2008
   STUDER RK, 1993, DIABETES, V42, P118, DOI 10.2337/diabetes.42.1.118
   Suarez-Pinzon WL, 2001, J AUTOIMMUN, V16, P449, DOI 10.1006/jaut.2001.0507
   Sugawara R, 2004, CURR EYE RES, V29, P11, DOI 10.1080/02713680490513146
   Szabó C, 2005, PHARMACOL RES, V52, P60, DOI 10.1016/j.phrs.2005.02.015
   Szabó C, 2002, CIRCULATION, V106, P2680, DOI 10.1161/01.CIR.0000038365.78031.9C
   Szabo C, 2007, NAT REV DRUG DISCOV, V6, P662, DOI 10.1038/nrd2222
   The effect ofintensive treatment of diabetes on the development and progression oflong- term complications in insulin- dependent diabetes mellitus. The Diabetes Control and Complication s Trial Research Group, 1993, N Engl J Med, V329, P77
   Thornalley PJ, 2002, INT REV NEUROBIOL, V50, P37
   Thuraisingham RC, 2000, KIDNEY INT, V57, P1968, DOI 10.1046/j.1523-1755.2000.00046.x
   Tiedge M, 1997, DIABETES, V46, P1733, DOI 10.2337/diabetes.46.11.1733
   VLASSARA H, 1988, SCIENCE, V240, P1546, DOI 10.1126/science.3259727
   Wells L, 2003, FEBS LETT, V546, P154, DOI 10.1016/S0014-5793(03)00641-0
   Wild S, 2004, DIABETES CARE, V27, P1047, DOI 10.2337/diacare.27.5.1047
   WOLFF SP, 1991, FREE RADICAL BIO MED, V10, P339, DOI 10.1016/0891-5849(91)90040-A
   Wrona M, 2005, FREE RADICAL BIO MED, V38, P262, DOI 10.1016/j.freeradbiomed.2004.10.022
   XIA P, 1994, DIABETES, V43, P1122, DOI 10.2337/diabetes.43.9.1122
   Yuan MS, 2001, SCIENCE, V293, P1673, DOI 10.1126/science.1061620
   Zielonka J, 2010, FREE RADICAL BIO MED, V48, P983, DOI 10.1016/j.freeradbiomed.2010.01.028
NR 124
TC 81
Z9 87
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
SN 0065-2598
EI 2214-8019
BN 978-1-4614-5441-0; 978-1-4614-5440-3
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2013
VL 771
BP 272
EP 287
D2 10.1007/978-1-4614-5441-0
PG 16
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA BA2XL
UT WOS:000333979500022
PM 23393685
DA 2025-06-11
ER

PT J
AU Salo, KI
   Scharfen, J
   Wilden, ID
   Schubotz, RI
   Holling, H
AF Salo, Katharina, I
   Scharfen, Jana
   Wilden, Isabelle D.
   Schubotz, Ricarda, I
   Holling, Heinz
TI Confining the Concept of Vascular Depression to Late-Onset Depression: A
   Meta-Analysis of MRI-Defined Hyperintensity Burden in Major Depressive
   Disorder and Bipolar Disorder
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Review
DE white matter hyperintensities (WMH); leukoaraiosis; major depressive
   disorder; bipolar disorder; depression; cerebrovascular pathology;
   hyperintense lesions
ID WHITE-MATTER HYPERINTENSITIES; LATE-LIFE DEPRESSION; ORBITOFRONTAL
   CORTEX VOLUME; CARDIOVASCULAR RISK-FACTORS; MILD COGNITIVE IMPAIRMENT;
   SIGNAL HYPERINTENSITIES; HOMOCYSTEINE LEVELS; METABOLIC SYNDROME;
   ELDERLY SUBJECTS; OLDER-ADULTS
AB Background: The vascular depression hypothesis emphasizes the significance of vascular lesions in late-life depression. At present, no meta-analytic model has investigated whether a difference in hyperintensity burden compared to controls between late-life and late-onset depression is evident. By including a substantial number of studies, focusing on a meaningful outcome measure, and considering several moderating and control variables, the present meta-analysis investigates the severity of hyperintensity burden in major depressive disorder (MDD) and bipolar disorder (BD). A major focus of the present meta-analysis refers to the role of age at illness onset. It is analyzed whether late-onset rather than late-life depression characterizes vascular depression.
   Method: In total, 68 studies were included in the meta-analysis and a multilevel random effects model was calculated using Hedges' g as the effect size measure.
   Results: The severity of hyperintensity burden was significantly greater in the patient group compared to the control group. This effect was evident regarding the whole patient group (g = 0.229) as well as both depression subgroups, with a significantly greater effect in BD (g = 0.374) compared to MDD (g = 0.189). Hyperintensity burden was more pronounced in late-onset depression than in early-onset depression or late-life depression. A considerable heterogeneity between the included studies was observed, which is reflected by the large variability in effects sizes.
   Conclusion: In conclusion, the present meta-analysis underscores the association of hyperintensities with MDD and BD. Especially late-onset depression is associated with an increased hyperintensity burden, which is in line with the vascular depression hypothesis. The results suggest that it might be more feasible to confine the concept of vascular depression specifically to late-onset depression as opposed to late-life depression. Further research is needed to understand the causal mechanisms that might underlie the relation between hyperintensity burden and depression.
C1 [Salo, Katharina, I; Scharfen, Jana; Wilden, Isabelle D.; Schubotz, Ricarda, I; Holling, Heinz] Westfalische Wilhelms Univ, Inst Psychol, Dept Psychol & Sports Sci, Munster, Germany.
C3 University of Munster
RP Salo, KI (corresponding author), Westfalische Wilhelms Univ, Inst Psychol, Dept Psychol & Sports Sci, Munster, Germany.
EM katharina.salo@gmail.com
RI Schubotz, Ricarda/B-2871-2013; Holling, Heinz/K-3728-2017
OI Schubotz, Ricarda/0000-0001-5802-6869; Holling,
   Heinz/0000-0002-0311-3970; Salo, Katharina Ida/0000-0002-8311-3195
CR Agid R, 2003, INT J NEUROPSYCHOPH, V6, P215, DOI 10.1017/S146114570300347X
   Ahn KH, 2004, PSYCHIAT CLIN NEUROS, V58, P516, DOI 10.1111/j.1440-1819.2004.01294.x
   Aizenstein HJ, 2016, BMC MED, V14, DOI 10.1186/s12916-016-0720-5
   Alexopoulos GS, 1997, ARCH GEN PSYCHIAT, V54, P915
   Allan C. L., 2014, THESIS
   Almeida OP, 2003, PSYCHOL MED, V33, P675, DOI 10.1017/S003329170300758X
   Almeida OP, 2007, AM J GERIAT PSYCHIAT, V15, P506, DOI 10.1097/01.JGP.0000246869.49892.77
   ALTSHULER LL, 1995, AM J PSYCHIAT, V152, P1139
   Alves GS, 2012, PSYCHIAT RES-NEUROIM, V203, P194, DOI 10.1016/j.pscychresns.2011.12.006
   American Psychiatric Association, 1987, DIAGN STAT MAN MENT
   Andreescu C, 2008, NEUROPSYCHOPHARMACOL, V33, P2566, DOI 10.1038/sj.npp.1301655
   Anorne D., 2012, EUR NEUROPSYCHOPHARM, V22, P1, DOI [10.1016/j.euroneuro.2011.05.003, DOI 10.1016/J.EURONEURO.2011.05.003]
   AWAD IA, 1986, STROKE, V17, P1090, DOI 10.1161/01.STR.17.6.1090
   Bakker SLM, 1999, NEUROLOGY, V52, P578, DOI 10.1212/WNL.52.3.578
   Beyer JL, 2009, INT REV PSYCHIATR, V21, P394, DOI 10.1080/09540260902962198
   Birner A, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0135313
   Bremmer MA, 2008, J AFFECT DISORDERS, V106, P249, DOI 10.1016/j.jad.2007.07.002
   BRETELER MMB, 1994, NEUROLOGY, V44, P1246, DOI 10.1212/WNL.44.7.1246
   BROWN FW, 1992, AM J PSYCHIAT, V149, P620
   Chen CS, 2006, INT J GERIATR PSYCH, V21, P36, DOI 10.1002/gps.1420
   Chen JD, 2012, J AFFECT DISORDERS, V143, P56, DOI 10.1016/j.jad.2012.05.025
   Chen YF, 2006, DEMENT GERIATR COGN, V22, P177, DOI 10.1159/000094785
   Choi WH, 2017, J AFFECT DISORDERS, V208, P47, DOI 10.1016/j.jad.2016.08.070
   COFFEY CE, 1990, AM J PSYCHIAT, V147, P187
   Cohen J., 1988, STAT POWER ANAL BEHA, DOI [10.4324/9780203771587, DOI 10.4324/9780203771587]
   Colloby SJ, 2011, BRIT J PSYCHIAT, V199, P404, DOI 10.1192/bjp.bp.110.090423
   Compta Y, 2016, J NEUROL SCI, V367, P284, DOI 10.1016/j.jns.2016.06.009
   Cooper H., 2009, The Handbook of Research Synthesis and Meta-Analysis, DOI [DOI 10.7758/9781610448864, 10.7758/9781610448864]
   Dalby RB, 2010, PSYCHOL MED, V40, P1389, DOI 10.1017/S0033291709991656
   Davis KA, 2004, J AFFECT DISORDERS, V82, P475, DOI 10.1016/j.jad.2004.03.010
   de Almeida JRC, 2013, BIOL PSYCHIAT, V73, P111, DOI 10.1016/j.biopsych.2012.06.010
   de Asis JM, 2006, AM J GERIAT PSYCHIAT, V14, P598, DOI 10.1097/01.JGP.0000200603.70504.d5
   de Groot JC, 2001, NEUROLOGY, V56, P1539, DOI 10.1212/WNL.56.11.1539
   de Leeuw FE, 2001, J NEUROL NEUROSUR PS, V70, P9, DOI 10.1136/jnnp.70.1.9
   Delaloye C, 2010, J NEUROL SCI, V299, P19, DOI 10.1016/j.jns.2010.08.046
   Disabato BM, 2014, AM J GERIAT PSYCHIAT, V22, P1039, DOI 10.1016/j.jagp.2013.02.005
   Dols A, 2017, AM J GERIAT PSYCHIAT, V25, P178, DOI 10.1016/j.jagp.2016.09.005
   Dotson VM, 2013, INT J GERIATR PSYCH, V28, P66, DOI 10.1002/gps.3791
   DUPONT RM, 1995, BIOL PSYCHIAT, V38, P482, DOI 10.1016/0006-3223(95)00100-U
   Egger K, 2008, PSYCHIAT RES-NEUROIM, V164, P237, DOI 10.1016/j.pscychresns.2007.12.018
   Egger M, 1997, BMJ-BRIT MED J, V315, P629, DOI 10.1136/bmj.315.7109.629
   El-Badri SM, 2006, BRIT J PSYCHIAT, V189, P81, DOI 10.1192/bjp.bp.105.011098
   Emsell L, 2017, J AFFECT DISORDERS, V222, P63, DOI 10.1016/j.jad.2017.06.063
   Farkas E, 2006, ACTA NEUROPATHOL, V111, P150, DOI 10.1007/s00401-005-0007-y
   FAZEKAS F, 1991, AM J NEURORADIOL, V12, P915
   FAZEKAS F, 1987, AM J NEURORADIOL, V8, P421
   Feng C, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/682092
   Fiedorowicz JG, 2008, ANN CLIN PSYCHIATRY, V20, P131, DOI 10.1080/10401230802177722
   Firbank MJ, 2012, BRIT J PSYCHIAT, V201, P40, DOI 10.1192/bjp.bp.111.098897
   Firbank MJ, 2004, AM J GERIAT PSYCHIAT, V12, P606, DOI 10.1176/appi.ajgp.12.6.606
   Foo H, 2016, PARKINSONISM RELAT D, V31, P34, DOI 10.1016/j.parkreldis.2016.06.019
   Fujimoto T, 2008, PSYCHIAT RES-NEUROIM, V164, P48, DOI 10.1016/j.pscychresns.2007.03.010
   Gattringer T, 2012, DEMENT GERIATR COGN, V33, P29, DOI 10.1159/000336052
   Gaupp R., 1905, MUNCHEN MED WOCHEN, V1531, P216
   Gildengers AG, 2015, BIPOLAR DISORD, V17, P248, DOI 10.1111/bdi.12260
   González HM, 2012, J PSYCHIATR RES, V46, P456, DOI 10.1016/j.jpsychires.2012.01.011
   Greenwald BS, 1996, AM J PSYCHIAT, V153, P1212
   Greenwald BS, 1998, STROKE, V29, P613, DOI 10.1161/01.STR.29.3.613
   Greenwald BS, 2001, J AM GERIATR SOC, V49, P1218, DOI 10.1046/j.1532-5415.2001.49240.x
   Gunde E, 2011, ANN MED, V43, P571, DOI 10.3109/07853890.2011.595733
   Gunning-Dixon FM, 2010, J AFFECT DISORDERS, V126, P395, DOI 10.1016/j.jad.2010.04.004
   Habes M, 2016, BRAIN, V139, P1164, DOI 10.1093/brain/aww008
   Hajer GR, 2007, HEART, V93, P216, DOI 10.1136/hrt.2006.093971
   Harada K, 2016, J AFFECT DISORDERS, V204, P112, DOI 10.1016/j.jad.2016.06.031
   Hedges LV., 1981, Journal of Educational Statistics, V6, P107, DOI [DOI 10.3102/10769986006002107, 10.3102/10769986006002107]
   HENDRIE HC, 1989, AM J NEURORADIOL, V10, P703
   Herrmann LL, 2008, J NEUROL NEUROSUR PS, V79, P619, DOI 10.1136/jnnp.2007.124651
   Hickie I, 2005, J AFFECT DISORDERS, V85, P327, DOI 10.1016/j.jad.2004.11.003
   Hogervorst E, 2002, ARCH NEUROL-CHICAGO, V59, P787, DOI 10.1001/archneur.59.5.787
   Hong ED, 2009, AM J GERIAT PSYCHIAT, V17, P847, DOI 10.1097/JGP.0b013e3181aad5b2
   Iosifescu DV, 2006, BRIT J PSYCHIAT, V188, P180, DOI 10.1192/bjp.188.2.180
   Iosifescu DV, 2005, PSYCHIAT RES-NEUROIM, V140, P291, DOI 10.1016/j.pscychresns.2005.09.003
   Jellinger KA, 2011, NEUROPATH APPL NEURO, V37, P560, DOI 10.1111/j.1365-2990.2011.01191.x
   Johnson AD, 2017, INT J GERIATR PSYCH, V32, pE10, DOI 10.1002/gps.4644
   Kearney PM, 2005, LANCET, V365, P217, DOI 10.1016/S0140-6736(05)70151-3
   Kempton MJ, 2008, ARCH GEN PSYCHIAT, V65, P1017, DOI 10.1001/archpsyc.65.9.1017
   Kempton MJ, 2011, ARCH GEN PSYCHIAT, V68, P675, DOI 10.1001/archgenpsychiatry.2011.60
   Keshavan MS, 1996, PSYCHIAT RES, V60, P117, DOI 10.1016/0165-1781(96)02867-3
   Kieseppä T, 2014, EUR PSYCHIAT, V29, P226, DOI 10.1016/j.eurpsy.2013.08.002
   Kim JM, 2008, BRIT J PSYCHIAT, V192, P268, DOI 10.1192/bjp.bp.107.039511
   Kim JH, 2010, INT J CARDIOL, V143, P154, DOI 10.1016/j.ijcard.2009.02.004
   KIRKPATRICK JB, 1987, RADIOLOGY, V162, P509, DOI 10.1148/radiology.162.2.3797666
   Kloppenborg RP, 2014, NEUROLOGY, V82, P2127, DOI 10.1212/WNL.0000000000000505
   Köhler S, 2011, INT PSYCHOGERIATR, V23, P141, DOI 10.1017/S1041610210001250
   Köhler S, 2010, BRIT J PSYCHIAT, V196, P143, DOI 10.1192/bjp.bp.109.071399
   Kovacic JC, 2011, CIRCULATION, V123, P1900, DOI 10.1161/CIRCULATIONAHA.110.009118
   Kramer-Ginsberg E, 1999, AM J PSYCHIAT, V156, P438
   Krishnan KRR, 1997, AM J PSYCHIAT, V154, P497
   Krishnan KRR, 2004, BIOL PSYCHIAT, V55, P390, DOI 10.1016/j.biopsych.2003.08.014
   Krishnan MS, 2006, INT J GERIATR PSYCH, V21, P983, DOI 10.1002/gps.1596
   Kumar A, 2000, NEUROPSYCHOPHARMACOL, V22, P264, DOI 10.1016/S0893-133X(99)00124-4
   Lee SH, 2003, BIOL PSYCHIAT, V54, P529, DOI 10.1016/S0006-3223(03)00063-5
   Lentz SR, 2005, J THROMB HAEMOST, V3, P1646, DOI 10.1111/j.1538-7836.2005.01364.x
   Lenze E, 1999, AM J PSYCHIAT, V156, P1602, DOI 10.1176/ajp.156.10.1602
   Lesser IM, 1996, AM J PSYCHIAT, V153, P1280
   Li JQ, 2016, J NEUROL NEUROSUR PS, V87, P476, DOI [10.1007/s12650-016-0404-4, 10.1136/jnnp-2014-310095]
   Liao WX, 2017, ONCOTARGET, V8, P76214, DOI 10.18632/oncotarget.19185
   Lin Hsiu-Fen, 2005, Kaohsiung Journal of Medical Sciences, V21, P405
   Liu R, 2018, J AFFECT DISORDERS, V235, P544, DOI 10.1016/j.jad.2018.04.065
   Lloyd AJ, 2009, ACTA PSYCHIAT SCAND, V120, P481, DOI 10.1111/j.1600-0447.2009.01416.x
   Lloyd AJ, 2004, BRIT J PSYCHIAT, V184, P488, DOI 10.1192/bjp.184.6.488
   Longstreth WT, 1996, STROKE, V27, P1274, DOI 10.1161/01.STR.27.8.1274
   Madsen K, 2012, NEUROBIOL AGING, V33, P2334, DOI 10.1016/j.neurobiolaging.2011.11.021
   Mahon K, 2010, NEUROSCI BIOBEHAV R, V34, P533, DOI 10.1016/j.neubiorev.2009.10.012
   Mak E, 2016, NEUROBIOL AGING, V48, P212, DOI 10.1016/j.neurobiolaging.2016.08.013
   Mantyla R, 1997, STROKE, V28, P1614, DOI 10.1161/01.STR.28.8.1614
   MARIN J, 1995, MECH AGEING DEV, V79, P71, DOI 10.1016/0047-6374(94)01551-V
   McDonald WM, 1999, BIOL PSYCHIAT, V45, P965, DOI 10.1016/S0006-3223(98)00341-2
   MCDONALD WM, 1991, PSYCHIAT RES-NEUROIM, V40, P211, DOI 10.1016/0925-4927(91)90013-G
   MILLER DS, 1994, AM J GERIAT PSYCHIAT, V2, P332, DOI 10.1097/00019442-199402040-00008
   Mokwa I. D., 2013, THESIS
   Moore PB, 2001, BRIT J PSYCHIAT, V178, P172, DOI 10.1192/bjp.178.2.172
   Müller N, 2006, MOL PSYCHIATR, V11, P680, DOI 10.1038/sj.mp.4001805
   Murata T, 2001, INT J GERIATR PSYCH, V16, P1129, DOI 10.1002/gps.501
   Nagai K, 2011, GERIATR GERONTOL INT, V11, P328, DOI 10.1111/j.1447-0594.2010.00686.x
   Nortje G, 2013, J AFFECT DISORDERS, V150, P192, DOI 10.1016/j.jad.2013.05.034
   OBrien J, 1996, BRIT J PSYCHIAT, V168, P477, DOI 10.1192/bjp.168.4.477
   Oh B. H., 2004, PSYCHOGERIATRICS, V4, P72, DOI [10.1111/j.1479-8301.2004.00054.x, DOI 10.1111/J.1479-8301.2004.00054.X]
   Pantoni L, 1997, STROKE, V28, P652, DOI 10.1161/01.STR.28.3.652
   Paranthaman R, 2010, BIOL PSYCHIAT, V68, P133, DOI 10.1016/j.biopsych.2010.04.017
   Patel MJ, 2012, PSYCHIAT RES-NEUROIM, V204, P117, DOI 10.1016/j.pscychresns.2012.09.006
   Payne ME, 2013, NUTRIENTS, V5, P2192, DOI 10.3390/nu5062192
   Penninx BWJH, 2003, BIOL PSYCHIAT, V54, P566, DOI 10.1016/S0006-3223(02)01811-5
   Permoda-Osip A, 2013, NEUROPSYCHOBIOLOGY, V68, P193, DOI 10.1159/000355292
   Pillai JJ, 2002, PSYCHIAT RES-NEUROIM, V114, P51, DOI 10.1016/S0925-4927(01)00129-9
   Pimontel MA, 2013, AM J GERIAT PSYCHIAT, V21, pS66, DOI 10.1016/j.jagp.2012.12.086
   Pompili M, 2013, WORLD J BIOL PSYCHIA, V14, P412, DOI 10.3109/15622975.2013.765593
   Portet Florence, 2012, Alzheimers Dement, V8, pS88, DOI 10.1016/j.jalz.2011.11.007
   Potter GG, 2007, NEUROPSYCHOPHARMACOL, V32, P2135, DOI 10.1038/sj.npp.1301339
   PUKELSHEIM F, 1994, AM STAT, V48, P88, DOI 10.2307/2684253
   Qiu WQ, 2017, INT J GERIATR PSYCH, V32, P214, DOI 10.1002/gps.4469
   RABINS PV, 1991, AM J PSYCHIAT, V148, P617
   Radanovic M, 2013, EXPERT REV NEUROTHER, V13, P483, DOI [10.1586/ERN.13.45, 10.1586/ern.13.45]
   Rapp MA, 2005, AM J PSYCHIAT, V162, P691, DOI 10.1176/appi.ajp.162.4.691
   Rej S, 2014, INT J GERIATR PSYCH, V29, P421, DOI 10.1002/gps.4021
   Rolstad S, 2016, PSYCHOL MED, V46, P3095, DOI 10.1017/S0033291716001641
   Rybakowski JK, 2006, BIOL PSYCHIAT, V60, P889, DOI 10.1016/j.biopsych.2006.03.025
   Sachdev P, 2004, J NEUROL SCI, V226, P25, DOI 10.1016/j.jns.2004.09.006
   Sachdev P, 2004, ARCH NEUROL-CHICAGO, V61, P1369, DOI 10.1001/archneur.61.9.1369
   Santos M, 2010, NEUROPATH APPL NEURO, V36, P661, DOI 10.1111/j.1365-2990.2010.01101.x
   Santos M, 2012, J NEUROL SCI, V322, P46, DOI 10.1016/j.jns.2012.05.048
   Sassi RB, 2003, J AFFECT DISORDERS, V77, P237, DOI 10.1016/S0165-0327(02)00170-2
   SCHELTENS P, 1993, J NEUROL SCI, V114, P7, DOI 10.1016/0022-510X(93)90041-V
   SCHELTENS P, 1995, NEUROLOGY, V45, P883, DOI 10.1212/WNL.45.5.883
   Schwichtenberg J, 2017, INT J GERIATR PSYCH, V32, P446, DOI 10.1002/gps.4487
   Sexton CE, 2012, ARCH GEN PSYCHIAT, V69, P680, DOI 10.1001/archgenpsychiatry.2011.1862
   Shaw JE, 2010, DIABETES RES CLIN PR, V87, P4, DOI 10.1016/j.diabres.2009.10.007
   Silverstone T, 2003, BIPOLAR DISORD, V5, P53, DOI 10.1034/j.1399-5618.2003.01208.x
   Smith PJ, 2009, BIOL PSYCHOL, V80, P361, DOI 10.1016/j.biopsycho.2008.11.001
   Sneed JR, 2008, BIOL PSYCHIAT, V64, P491, DOI 10.1016/j.biopsych.2008.03.032
   Sneed JR, 2011, J AFFECT DISORDERS, V135, P315, DOI 10.1016/j.jad.2011.06.052
   Steffens DC, 2001, J ECT, V17, P45, DOI 10.1097/00124509-200103000-00009
   Steffens DC, 1998, BIOL PSYCHIAT, V43, P705, DOI 10.1016/S0006-3223(98)00084-5
   Sterne JAC, 2005, PUBLICATION BIAS IN META-ANALYSIS: PREVENTION, ASSESSMENT AND ADJUSTMENTS, P99
   SuttonTyrrell K, 1997, CIRCULATION, V96, P1745, DOI 10.1161/01.CIR.96.6.1745
   Takahashi Keisuke, 2012, Seishin Shinkeigaku Zasshi, V114, P297
   Tamashiro JH, 2008, BIPOLAR DISORD, V10, P765, DOI 10.1111/j.1399-5618.2008.00621.x
   Tawakol A, 1997, CIRCULATION, V95, P1119
   Taylor WD, 2013, MOL PSYCHIATR, V18, P963, DOI 10.1038/mp.2013.20
   Taylor WD, 2007, PSYCHOL MED, V37, P1763, DOI 10.1017/S0033291707000128
   Taylor WD, 2008, AM J GERIAT PSYCHIAT, V16, P263, DOI 10.1097/JGP.0b013e3181591c30
   Taylor WD, 2014, AM J GERIAT PSYCHIAT, V22, P1504, DOI 10.1016/j.jagp.2013.11.004
   Taylor WD, 2013, HUM BRAIN MAPP, V34, P295, DOI 10.1002/hbm.21445
   Taylor WD, 2001, BIOL PSYCHIAT, V50, P179, DOI 10.1016/S0006-3223(01)01160-X
   Taylor WD, 2005, PSYCHIAT RES-NEUROIM, V139, P1, DOI 10.1016/j.pscychresns.2004.08.004
   Teodorczuk A, 2007, BRIT J PSYCHIAT, V191, P212, DOI 10.1192/bjp.bp.107.036756
   Teodorczuk A, 2010, PSYCHOL MED, V40, P603, DOI 10.1017/S0033291709990857
   Thomas AJ, 2003, J AFFECT DISORDERS, V76, P49, DOI 10.1016/S0165-0327(02)00064-2
   Thomas AJ, 2002, ANN NY ACAD SCI, V977, P333, DOI 10.1111/j.1749-6632.2002.tb04835.x
   Tighe SK, 2012, BIPOLAR DISORD, V14, P888, DOI 10.1111/bdi.12019
   Tseng YL, 2009, J NEUROL SCI, V284, P36, DOI 10.1016/j.jns.2009.03.030
   Tupler LA, 2002, J PSYCHOSOM RES, V53, P665, DOI 10.1016/S0022-3999(02)00425-7
   van Agtmaal MJM, 2017, JAMA PSYCHIAT, V74, P729, DOI 10.1001/jamapsychiatry.2017.0984
   Van den Noortgate W, 2013, BEHAV RES METHODS, V45, P576, DOI 10.3758/s13428-012-0261-6
   Vasudev A, 2012, AM J GERIAT PSYCHIAT, V20, P691, DOI 10.1097/JGP.0b013e31824c0435
   Vernooij MW, 2008, NEUROIMAGE, V43, P470, DOI 10.1016/j.neuroimage.2008.07.052
   Versace A, 2010, BIOL PSYCHIAT, V68, P560, DOI 10.1016/j.biopsych.2010.04.036
   Versluis CE, 2006, INT J GERIATR PSYCH, V21, P375, DOI 10.1002/gps.1477
   Videbech P, 1997, ACTA PSYCHIAT SCAND, V96, P157, DOI 10.1111/j.1600-0447.1997.tb10146.x
   Viechtbauer W, 2010, J STAT SOFTW, V36, P1, DOI 10.18637/jss.v036.i03
   Wang L, 2014, J PSYCHIATR RES, V56, P56, DOI 10.1016/j.jpsychires.2014.05.005
   Wassmann S, 2004, CIRC RES, V94, P534, DOI 10.1161/01.RES.0000115557.25127.8D
   Weber K, 2010, J AFFECT DISORDERS, V124, P275, DOI 10.1016/j.jad.2009.11.016
   World Health Organization, 2018, The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines
   Wu RH, 2014, INT J MED SCI, V11, P587, DOI 10.7150/ijms.8025
   Xekardaki A, 2012, ACTA NEUROPATHOL, V124, P453, DOI 10.1007/s00401-012-1021-5
   Yin ZG, 2014, EUR J NEUROL, V21, P1032, DOI 10.1111/ene.12433
   Zhu GuoXing Zhu GuoXing, 2014, Healthmed, V8, P275
   Zupan M, 2015, BMC NEUROL, V15, DOI 10.1186/s12883-015-0416-z
NR 189
TC 32
Z9 36
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD MAY 31
PY 2019
VL 10
AR 1241
DI 10.3389/fpsyg.2019.01241
PG 21
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA IB4VX
UT WOS:000470271300001
PM 31214072
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Woodward, ML
   Gicas, KM
   Warburton, DE
   White, RF
   Rauscher, A
   Leonova, O
   Su, W
   Smith, GN
   Thornton, AE
   Vertinsky, AT
   Phillips, AA
   Goghari, VM
   Honer, WG
   Lang, DJ
AF Woodward, M. L.
   Gicas, K. M.
   Warburton, D. E.
   White, R. F.
   Rauscher, A.
   Leonova, O.
   Su, W.
   Smith, G. N.
   Thornton, A. E.
   Vertinsky, A. T.
   Phillips, A. A.
   Goghari, V. M.
   Honer, W. G.
   Lang, D. J.
TI Hippocampal volume and vasculature before and after exercise in
   treatment-resistant schizophrenia
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE Schizophrenia; Hippocampal plasticity; MRI; SWI; Exercise; Symptoms
ID MAJOR DEPRESSIVE DISORDER; SEVERE MENTAL-ILLNESS; PHYSICAL-ACTIVITY;
   AEROBIC EXERCISE; BIPOLAR DISORDER; ANTIPSYCHOTIC-NAIVE; ADULT
   NEUROGENESIS; METABOLIC SYNDROME; PEOPLE; METAANALYSIS
AB Background: Schizophrenia is associated with poor cognitive function and elevated cardiometabolic disease risk. These health concerns may exacerbate neurocognitive dysfunction associated with hippocampal abnormalities, particularly hippocampal volume reductions. Regular exercise is thought to improve symptom severity, reduce depression, and improve cognition in schizophrenia, and may trigger exercise-mediated hippocampal growth. The potential for the benefits of exercise for treatment-resistant schizophrenia patients has not been clearly assessed. This study aims to assess the effect of exercise on hippocampal plasticity and dinical outcomes in chronic schizophrenia.
   Methods: Seventeen DSM-IV criteria schizophrenia or schizoaffective disorder patients completed a customized moderate intensity 12-week aerobic or weight-bearing exercise program. Adherence rates were 83% +/- 9.4%) with 70% of participants completing the entire exercise program. Concomitant neuroimaging, clinical and cognitive assessments were obtained at baseline and 12-weeks.
   Results: At follow-up, symptom severity scores (t(16) = -16.8, p. <= 0.0001) and social functioning (t(16) = 4.4, p. = 0.0004) improved. A trend for improved depression scores (t(16) = -2.0, p. = 0.06) with no change in anxiety, or extrapyramidal symptoms were seen. Hippocampal volume increased (t(16) = -2.54, p. = 0.02), specifically in the left CA-1 field (F(16) = -2.33, p. = 0.03). Hippocampal vascular volume was unchanged. Change in hippocampal volume and vascular volume was not significantly correlated with change in symptom severity or affect scores.
   Conclusions: Adjunct exercise may accelerate symptom improvement in treatment-resistant psychosis patients. While the underlying mechanism remains unclear, these results indicate that chronic schizophrenia patients experience hippocampal plasticity in response to exercise. (C) 2018 Elsevier B.V. All rights reserved.
C1 [Woodward, M. L.; Vertinsky, A. T.; Lang, D. J.] Univ British Columbia, Dept Radiol, Vancouver, BC, Canada.
   [Gicas, K. M.] Simon Fraser Univ, Dept Psychol, Burnaby, BC, Canada.
   [Warburton, D. E.; Phillips, A. A.] Univ British Columbia, Sch Kinesiol, Vancouver, BC, Canada.
   [Warburton, D. E.] Univ British Columbia, Expt Med Program, Vancouver, BC, Canada.
   [White, R. F.; Leonova, O.; Su, W.; Smith, G. N.; Honer, W. G.] Univ British Columbia, Dept Psychiat, Vancouver, BC, Canada.
   [Rauscher, A.; Thornton, A. E.] Univ British Columbia, Dept Pediat, Vancouver, BC, Canada.
   [Goghari, V. M.] Univ Toronto, Dept Psychol, Toronto, ON, Canada.
   [Goghari, V. M.] Univ Toronto, Grad Dept Psychol Clin Sci, Toronto, ON, Canada.
C3 University of British Columbia; Simon Fraser University; University of
   British Columbia; University of British Columbia; University of British
   Columbia; University of British Columbia; University of Toronto;
   University of Toronto
RP Lang, DJ (corresponding author), BC Childrens Hosp, British Columbia Mental Hlth & Addict Res Inst, British Columbia Childrens Hosp Res Inst, Ctr Complex Disorders, Rm 3A-124 398 West 28th Ave, Vancouver, BC V5Z 4H4, Canada.
EM dlang@mail.ubc.ca
RI Rauscher, Alexander/AFV-6957-2022; Lang, Donna/GVR-9040-2022; Woodward,
   Melissa/ABG-3627-2020; Warburton, Darren/A-2668-2019
OI Warburton, Darren/0000-0002-2842-9170; Lang, Donna/0000-0001-9373-1555;
   Woodward, Melissa/0000-0003-2697-5343
FU Canadian Institutes for Health Research, BC Mental Health Authority
   Research Services
FX The Canadian Institutes for Health Research, BC Mental Health Authority
   Research Services provided all operating funds for this study. No funds
   were apportioned for other uses and no personal benefits were provided
   to Dr. Lang or her colleagues.
CR ADDINGTON D, 1994, SCHIZOPHR RES, V11, P239, DOI 10.1016/0920-9964(94)90017-5
   Addington J, 2000, SCHIZOPHR RES, V44, P47, DOI 10.1016/S0920-9964(99)00160-7
   Barr AM, 2013, NEUROSCIENCE, V255, P147, DOI 10.1016/j.neuroscience.2013.10.010
   Bartley CA, 2013, PROG NEURO-PSYCHOPH, V45, P34, DOI 10.1016/j.pnpbp.2013.04.016
   Boyer P, 2007, BRAIN RES REV, V54, P92, DOI 10.1016/j.brainresrev.2006.12.008
   Bushe Chris J, 2012, J Clin Psychiatry, V73, pe749, DOI 10.4088/JCP.11m07246
   CHOUINARD G, 1980, CAN J NEUROL SCI, V7, P233
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   Daumit GL, 2013, NEW ENGL J MED, V368, P1594, DOI 10.1056/NEJMoa1214530
   Hert M, 2012, NAT REV ENDOCRINOL, V8, P114, DOI 10.1038/nrendo.2011.156
   Dykiert D, 2013, PSYCHOL ASSESSMENT, V25, P1361, DOI 10.1037/a0033623
   Ebdrup BH, 2011, INT J NEUROPSYCHOPH, V14, P69, DOI 10.1017/S1461145710000817
   Eisch AJ, 2008, J NEUROSCI, V28, P11785, DOI 10.1523/JNEUROSCI.3798-08.2008
   Elkis H, 2016, PSYCHIAT CLIN N AM, V39, P239, DOI 10.1016/j.psc.2016.01.006
   Erickson KI, 2014, NEUROBIOL AGING, V35, pS20, DOI 10.1016/j.neurobiolaging.2014.03.034
   Fernandez-Egea E, 2009, BRIT J PSYCHIAT, V194, P434, DOI 10.1192/bjp.bp.108.052605
   Firth J, 2015, PSYCHOL MED, V45, P1343, DOI 10.1017/S0033291714003110
   Firth J, 2017, SCHIZOPHRENIA BULL, V43, P546, DOI 10.1093/schbul/sbw115
   Fleischhaker C, 2007, J NEURAL TRANSM, V114, P273, DOI 10.1007/s00702-006-0602-7
   Fung CCA, 2013, FRONT COMPUT NEUROSC, V7, DOI 10.3389/fncom.2013.00073
   Gillespie AL, 2017, BMC PSYCHIATRY, V17, DOI 10.1186/s12888-016-1177-y
   Gorczynski P, 2010, SCHIZOPHRENIA BULL, V36, P665, DOI 10.1093/schbul/sbq049
   Gupta A, 2009, EPIDEMIOL PSICHIAT S, V18, P200, DOI 10.1017/S1121189X00000476
   HAMILTON M, 1959, BRIT J MED PSYCHOL, V32, P50, DOI 10.1111/j.2044-8341.1959.tb00467.x
   Ho BC, 2010, NEUROIMAGE, V49, P3385, DOI 10.1016/j.neuroimage.2009.11.033
   Hoshi Y, 2006, SCHIZOPHR RES, V84, P411, DOI 10.1016/j.schres.2006.03.010
   Iwashiro N, 2012, SCHIZOPHR RES, V137, P124, DOI 10.1016/j.schres.2012.02.024
   Jenkinson M, 2002, NEUROIMAGE, V17, P825, DOI 10.1006/nimg.2002.1132
   Kanahara N, 2013, SCHIZOPHR RES, V143, P246, DOI 10.1016/j.schres.2012.11.015
   Kaufman A.S., 2006, Assessing adolescent and adult intelligence, V3rd
   Kay S. R., 1987, POSITIVE NEGATIVE SY
   Kerr AL, 2010, NEUROSCIENCE, V171, P214, DOI 10.1016/j.neuroscience.2010.08.008
   Kim David D, 2017, Clin Schizophr Relat Psychoses, DOI 10.3371/CSRP.DKDL.071317
   Lambert T.J., 2010, ADV BIOL PSYCHIAT TH
   Laursen TM, 2012, CURR OPIN PSYCHIATR, V25, P83, DOI 10.1097/YCO.0b013e32835035ca
   Layland JJ, 2009, MED J AUSTRALIA, V190, P190, DOI 10.5694/j.1326-5377.2009.tb02345.x
   Leavitt VM, 2014, NEUROCASE, V20, P695, DOI 10.1080/13554794.2013.841951
   Li H, 2005, NEUROSCI LETT, V386, P160, DOI 10.1016/j.neulet.2005.06.009
   Lin JX, 2015, NPJ SCHIZOPHR, V1, DOI 10.1038/npjschz.2015.47
   Maass A, 2015, MOL PSYCHIATR, V20, P585, DOI 10.1038/mp.2014.114
   Malchow B, 2016, SCHIZOPHR RES, V173, P182, DOI 10.1016/j.schres.2015.01.005
   Mondelli V, 2010, SCHIZOPHR RES, V119, P75, DOI 10.1016/j.schres.2009.12.021
   Mouchlianitis E, 2016, LANCET PSYCHIAT, V3, P451, DOI 10.1016/S2215-0366(15)00540-4
   Muench J, 2010, AM FAM PHYSICIAN, V81, P617
   O'Brien JT, 2003, LANCET NEUROL, V2, P89, DOI 10.1016/S1474-4422(03)00305-3
   Pajonk FG, 2010, ARCH GEN PSYCHIAT, V67, P133, DOI 10.1001/archgenpsychiatry.2009.193
   Pereira AC, 2007, P NATL ACAD SCI USA, V104, P5638, DOI 10.1073/pnas.0611721104
   Protopopova D, 2012, PSYCHIAT DANUB, V24, P307
   Ramos-Miguel A, 2015, NEUROSCIENCE, V301, P298, DOI 10.1016/j.neuroscience.2015.06.022
   Ringen PA, 2014, FRONT PSYCHIATRY, V5, DOI 10.3389/fpsyt.2014.00137
   Riordan HJ, 2011, AM HEALTH DRUG BENEF, V4, P292
   Rybarczyk B, 2011, ENCY CLIN NEUROPSYCH
   Scheewe TW, 2013, ACTA PSYCHIAT SCAND, V127, P464, DOI 10.1111/acps.12029
   Schubert MI, 2008, J PSYCHIATR RES, V42, P902, DOI 10.1016/j.jpsychires.2007.10.003
   Seifert T, 2010, AM J PHYSIOL-REG I, V298, pR372, DOI 10.1152/ajpregu.00525.2009
   Stubbs B, 2016, SCHIZOPHR RES, V176, P431, DOI 10.1016/j.schres.2016.05.017
   ten Brinke LF, 2015, BRIT J SPORT MED, V49, P248, DOI 10.1136/bjsports-2013-093184
   Vancampfort D, 2017, WORLD PSYCHIATRY, V16, P308, DOI 10.1002/wps.20458
   Vancampfort D, 2017, SPORTS MED, V47, P343, DOI 10.1007/s40279-016-0574-1
   Vancampfort D, 2016, WORLD PSYCHIATRY, V15, P166, DOI 10.1002/wps.20309
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vancampfort D, 2013, PSYCHIAT RES, V207, P25, DOI 10.1016/j.psychres.2012.09.026
   Vancampfort D, 2011, DISABIL REHABIL, V33, P684, DOI 10.3109/09638288.2010.509458
   Verma S, 2009, J NEUROPSYCH CLIN N, V21, P24, DOI 10.1176/appi.neuropsych.21.1.24
   Warburton DER, 2006, CAN MED ASSOC J, V174, P961, DOI 10.1503/cmaj.1040750
   Wolf SA, 2011, BRAIN BEHAV IMMUN, V25, P971, DOI 10.1016/j.bbi.2010.10.014
NR 66
TC 36
Z9 42
U1 2
U2 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD DEC
PY 2018
VL 202
BP 158
EP 165
DI 10.1016/j.schres.2018.06.054
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HD1UW
UT WOS:000452298400024
PM 30539767
DA 2025-06-11
ER

PT J
AU Faith, MS
   Calamaro, CJ
   Dolan, MS
   Pietrobelli, A
AF Faith, MS
   Calamaro, CJ
   Dolan, MS
   Pietrobelli, A
TI Mood disorders and obesity
SO CURRENT OPINION IN PSYCHIATRY
LA English
DT Article
DE obesity; mood disorders; depression; moderator; mediator; comorbidity
ID METABOLIC SYNDROME; BODY-FAT; DEPRESSION; RISK; ASSOCIATION
AB Purpose of review
   The aim of this article is to provide an updated review of studies examining the relationship between mood disorders and obesity that have been published within the past year. The increasing number of studies using novel designs to address this topic necessitates an updated review.
   Recent findings
   The literature on mood disorders and obesity is gradually moving beyond cross-sectional designs that compare 'obese' and 'non-obese' individuals with respect to psychological functioning. An increasing number of studies have used prospective designs, tested physiological pathways linking disorders, explored changes in weight status and psychological functioning in response to treatment, and used genetic designs to examine co-morbidities.
   Summary
   Novel designs, most notably prospective studies, are advancing the understanding of the relationships between obesity and mood disorders. The use of a 'moderator-mediator' framework may facilitate the conceptualization of questions and the design of new studies.
C1 Univ Penn, Sch Med, Weight & Eating Disorders Program, Philadelphia, PA 19104 USA.
   Univ Verona, Sch Med, I-37100 Verona, Italy.
   Columbia Univ, St Lukes Roosevelt Hosp, NY Obes Res Ctr, New York, NY 10027 USA.
C3 University of Pennsylvania; University of Verona; Mount Sinai West;
   Mount Sinai St. Luke's; Columbia University
RP Univ Penn, Sch Med, Weight & Eating Disorders Program, Philadelphia, PA 19104 USA.
EM mfaith@mail.med.upenn.edu
CR Carpenter KM, 2000, AM J PUBLIC HEALTH, V90, P251, DOI 10.2105/AJPH.90.2.251
   Carpenter LL, 2002, J AFFECT DISORDERS, V69, P251, DOI 10.1016/S0165-0327(01)00337-8
   Decaluwé V, 2003, INT J EAT DISORDER, V33, P78, DOI 10.1002/eat.10110
   Fagiolini A, 2003, AM J PSYCHIAT, V160, P112, DOI 10.1176/appi.ajp.160.1.112
   Faith MS, 2002, J PSYCHOSOM RES, V53, P935, DOI 10.1016/S0022-3999(02)00308-2
   Faith MS., 1996, BODY IMAGE EATING DI, P365
   Foster GD, 2003, NEW ENGL J MED, V348, P2082, DOI 10.1056/NEJMoa022207
   FRIEDMAN MA, 1995, PSYCHOL BULL, V117, P3, DOI 10.1037/0033-2909.117.1.3
   Goodman E, 2002, PEDIATRICS, V110, P497, DOI 10.1542/peds.110.3.497
   ISTVAN J, 1992, INT J OBESITY, V16, P999
   Ladwig KH, 2003, BRAIN BEHAV IMMUN, V17, P268, DOI 10.1016/S0889-1591(03)00056-4
   Laederach-Hofmann K, 2002, INT J EAT DISORDER, V32, P58, DOI 10.1002/eat.10063
   McCaffery JM, 2003, PSYCHOSOM MED, V65, P490, DOI 10.1097/01.PSY.0000041545.52924.82
   McElroy SL, 2002, J CLIN PSYCHIAT, V63, P207, DOI 10.4088/JCP.v63n0306
   Mendall MA, 1996, BRIT MED J, V312, P1061
   Mustillo S, 2003, PEDIATRICS, V111, P851, DOI 10.1542/peds.111.4.851
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Richardson LP, 2003, ARCH PEDIAT ADOL MED, V157, P739, DOI 10.1001/archpedi.157.8.739
   Roberts RE, 2003, INT J OBESITY, V27, P514, DOI 10.1038/sj.ijo.0802204
   Stunkard AJ, 2003, BIOL PSYCHIAT, V54, P330, DOI 10.1016/S0006-3223(03)00608-5
   Stunkard AJ, 2003, INT J EAT DISORDER, V34, pS107, DOI 10.1002/eat.10210
   THOMPSON JK, 1995, INT J EAT DISORDER, V18, P221, DOI 10.1002/1098-108X(199511)18:3<221::AID-EAT2260180304>3.0.CO;2-D
   Zhu SK, 2003, AM J CLIN NUTR, V78, P228, DOI 10.1093/ajcn/78.2.228
NR 23
TC 23
Z9 31
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0951-7367
EI 1473-6578
J9 CURR OPIN PSYCHIATR
JI Curr. Opin. Psychiatr.
PD JAN
PY 2004
VL 17
IS 1
BP 9
EP 13
DI 10.1097/00001504-200401000-00003
PG 5
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA 774MH
UT WOS:000188982900003
DA 2025-06-11
ER

PT J
AU Wang, MX
   Li, Z
   Li, CT
   Liu, YM
   Jiang, HK
   Jia, LH
   Zhai, LL
   Sun, Q
   Wei, W
   Bai, YL
AF Wang, Mingxia
   Li, Zhao
   Li, Chuntao
   Liu, Yamin
   Jiang, Hongkun
   Jia, Lihong
   Zhai, Lingling
   Sun, Qi
   Wei, Wei
   Bai, Yinglong
TI Endoplasmic reticulum stress in adipose tissue at the intersection of
   childhood obesity-associated type 2 diabetes/insulin resistance and
   atherosclerosis
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Review
DE Adipose tissue; atherosclerosis; childhood obesity; diabetes mellitus;
   endoplasmic reticulum stress
ID UNFOLDED PROTEIN RESPONSE; CARDIOVASCULAR RISK-FACTORS; ER STRESS;
   INSULIN-RESISTANCE; CARDIOMETABOLIC RISK; INFLAMMATORY CHANGES;
   UNITED-STATES; FATTY-ACIDS; CHILDREN; YOUNG
AB Childhood obesity contributing to the development of metabolic diseases is a serious public health challenge on a global scale. Abnormal or excessive fat accumulation is obvious in children who are overweight or obese. As a complicated endocrine organ, adipose tissue is a predominant site of endoplasmic reticulum stress (ERS) that is induced by obesity. ERS is aggravated in obese adipose tissues, which are recognized as a molecular link between obesity and the development of metabolic diseases, such as type 2 diabetes/insulin resistance (T2D/IR) and atherosclerosis. Moreover, T2D increases the risk of atherosclerotic cardiovascular diseases (CVDs). In this review, the role of ERS in adipose tissues is analyzed, particularly regarding the initiation and exacerbation of T2D/IR and atherosclerosis. These findings indicate that it is necessary to devote more resources to the development of promising therapeutics and effective drugs to relieve ERS for the treatment of T2D and atherosclerosis, especially in children who are overweight or obese.
C1 [Wang, Mingxia; Jia, Lihong; Zhai, Lingling; Sun, Qi; Wei, Wei; Bai, Yinglong] China Med Univ, Sch Publ Hlth, Dept Child & Adolescent Hlth, Shenyang, Liaoning, Peoples R China.
   [Li, Chuntao] China Med Univ, Hosp 1, Informat Ctr, Shenyang, Liaoning, Peoples R China.
   [Li, Zhao] China Med Univ, Hosp 1, Dept Cardiol, Shenyang, Liaoning, Peoples R China.
   [Jiang, Hongkun] China Med Univ, Hosp 1, Dept Pediat, Shenyang, Liaoning, Peoples R China.
   [Liu, Yamin] Univ Calif San Francisco, Dept Cardiol, San Francisco, CA 94143 USA.
C3 China Medical University; China Medical University; China Medical
   University; China Medical University; University of California System;
   University of California San Francisco
RP Bai, YL (corresponding author), China Med Univ, Sch Publ Hlth, Dept Child & Adolescent Hlth, Shenyang North New Area, 77 Puhe Rd, Shenyang 110122, Liaoning, Peoples R China.
EM ylbai@cmu.edu.cn
RI Liu, Yamin/E-3353-2019; 白, 英龙/AAF-6124-2020
FU National Natural Science Foundation Committee of China [81373018,
   81172691]
FX The work was supported by the National Natural Science Foundation
   Committee of China (No. 81373018 and 81172691).
CR Alhusaini S, 2010, BIOCHEM BIOPH RES CO, V397, P472, DOI 10.1016/j.bbrc.2010.05.138
   Amed Shazhan, 2010, Diabetes Care, V33, P786, DOI 10.2337/dc09-1013
   [Anonymous], 2017, Obesity
   [Anonymous], 2015, Cardiovascular diseases
   Benbrook D. M., 2012, Experimental Oncology, V34, P286
   Boden G, 2008, DIABETES, V57, P2438, DOI 10.2337/db08-0604
   Boden G, 2011, METHOD ENZYMOL, V489, P67, DOI 10.1016/B978-0-12-385116-1.00004-2
   BOURGEOIS F, 1983, BRIT J NUTR, V49, P17, DOI 10.1079/BJN19830006
   Brewer JW, 2014, CELL MOL LIFE SCI, V71, P1067, DOI 10.1007/s00018-013-1490-2
   Chakrabarti A, 2011, BIOTECHNOL BIOENG, V108, P2777, DOI 10.1002/bit.23282
   陈伟伟, 2016, [中国循环杂志, Chinese Circulation Journal], V31, P521
   Chen X, 2011, VET PATHOL, V48, P245, DOI 10.1177/0300985810385154
   Cinti S, 2005, J LIPID RES, V46, P2347, DOI 10.1194/jlr.M500294-JLR200
   Dabelea D, 2017, JAMA-J AM MED ASSOC, V317, P825, DOI 10.1001/jama.2017.0686
   Daniels SR, 2008, PEDIATRICS, V122, P198, DOI 10.1542/peds.2008-1349
   Davis PH, 2001, CIRCULATION, V104, P2815, DOI 10.1161/hc4601.099486
   DeFronzo R.A., 2015, International Textbook of Diabetes Mellitus
   Deshmukh-Taskar P, 2006, EUR J CLIN NUTR, V60, P48, DOI 10.1038/sj.ejcn.1602266
   Dickhout JG, 2011, FASEB J, V25, P576, DOI 10.1096/fj.10-159319
   Ding WQ, 2016, J EPIDEMIOL, V26, P637, DOI 10.2188/jea.JE20140252
   Fonseca V, 2004, ENDOCR REV, V25, P153, DOI 10.1210/er.2002-0034
   Ford ES, 2003, CIRCULATION, V108, P1053, DOI 10.1161/01.CIR.0000080913.81393.B8
   Fu JF, 2013, WORLD J PEDIATR, V9, P127, DOI 10.1007/s12519-013-0414-4
   Gan L, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01507
   Gual P, 2005, BIOCHIMIE, V87, P99, DOI 10.1016/j.biochi.2004.10.019
   Guo QY, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0425-6
   Hida K, 2005, P NATL ACAD SCI USA, V102, P10610, DOI 10.1073/pnas.0504703102
   Jayawardene WP, 2017, CLIN OBES, V7, P11, DOI 10.1111/cob.12171
   Jefferies Craig, 2012, Pediatr Diabetes, V13, P294, DOI 10.1111/j.1399-5448.2012.00851.x
   Ka SO, 2015, J ENDOCRINOL, V224, P109, DOI 10.1530/JOE-14-0527
   Kahn SE, 2006, NATURE, V444, P840, DOI 10.1038/nature05482
   Kamiya T, 2013, J CLIN BIOCHEM NUTR, V52, P101, DOI 10.3164/jcbn.12-46
   KANNEL WB, 1979, JAMA-J AM MED ASSOC, V241, P2035, DOI 10.1001/jama.241.19.2035
   Kars M, 2010, DIABETES, V59, P1899, DOI 10.2337/db10-0308
   Kawasaki N, 2012, SCI REP-UK, V2, DOI 10.1038/srep00799
   Khullar M, 2017, FRONT ENDOCRINOL, V8, DOI 10.3389/fendo.2017.00237
   Kim DS, 2007, BIOCHEM BIOPH RES CO, V363, P140, DOI 10.1016/j.bbrc.2007.08.151
   Krishnan S, 2010, AM J CLIN NUTR, V91, P465, DOI 10.3945/ajcn.2009.28682
   l'Allemand-Jander D, 2010, INT J OBESITY, V34, pS32, DOI 10.1038/ijo.2010.237
   Lamharzi N, 2004, DIABETES, V53, P3217, DOI 10.2337/diabetes.53.12.3217
   Lee J, 2014, J BIOL CHEM, V289, P1203, DOI 10.1074/jbc.R113.534743
   Li LL, 2016, CHILD OBES, V12, P12, DOI 10.1089/chi.2015.0136
   Li SX, 2003, JAMA-J AM MED ASSOC, V290, P2271, DOI 10.1001/jama.290.17.2271
   LILLIOJA S, 1993, NEW ENGL J MED, V329, P1988, DOI 10.1056/NEJM199312303292703
   Lin Y, 2016, MOL MED REP, V13, P1509, DOI 10.3892/mmr.2015.4708
   Lohmann C, 2009, ATHEROSCLEROSIS, V207, P360, DOI 10.1016/j.atherosclerosis.2009.05.004
   Lumeng CN, 2007, J CLIN INVEST, V117, P175, DOI 10.1172/JCI29881
   Magnussen CG, 2009, J AM COLL CARDIOL, V53, P860, DOI 10.1016/j.jacc.2008.09.061
   Mayer-Davis EJ, 2017, NEW ENGL J MED, V376, P1419, DOI 10.1056/NEJMoa1610187
   McWhorter FY, 2015, CELL MOL LIFE SCI, V72, P1303, DOI 10.1007/s00018-014-1796-8
   Mills CD, 2012, CRIT REV IMMUNOL, V32, P463, DOI 10.1615/CritRevImmunol.v32.i6.10
   Misra A, 2000, J CARDIOVASC RISK, V7, P215
   Morel O, 2013, SEMIN THROMB HEMOST, V39, P477, DOI 10.1055/s-0033-1343888
   Myoishi M, 2007, CIRCULATION, V116, P1226, DOI 10.1161/CIRCULATIONAHA.106.682054
   O'Connor EA, 2017, JAMA-J AM MED ASSOC, V317, P2427, DOI 10.1001/jama.2017.0332
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Ogden CL CM, 2015, PREVALENCE CHILDHOOD
   Ogden CL, 2014, JAMA-J AM MED ASSOC, V311, P806, DOI 10.1001/jama.2014.732
   Olds T, 2011, INT J PEDIATR OBES, V6, P342, DOI 10.3109/17477166.2011.605895
   Olefsky JM, 2010, ANNU REV PHYSIOL, V72, P219, DOI 10.1146/annurev-physiol-021909-135846
   Oliveira FLC, 2010, EXPERT REV CARDIOVAS, V8, P513, DOI 10.1586/ERC.09.170
   Ouchi N, 2016, J ATHEROSCLER THROMB, V23, P645, DOI 10.5551/jat.34918
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Parathath S, 2011, DIABETES, V60, P1759, DOI 10.2337/db10-0778
   Proença ARG, 2014, BRAZ J MED BIOL RES, V47, P192, DOI 10.1590/1414-431X20132911
   Renard CB, 2004, J CLIN INVEST, V114, P659, DOI 10.1172/JCI200417867
   Rhodes ET, 2012, DIABETIC MED, V29, P453, DOI 10.1111/j.1464-5491.2011.03542.x
   Sanada Y, 2014, BIOSCI BIOTECH BIOCH, V78, P1357, DOI 10.1080/09168451.2014.925776
   Sanada Y, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061931
   Schröder M, 2005, MUTAT RES-FUND MOL M, V569, P29, DOI 10.1016/j.mrfmmm.2004.06.056
   Seimon T, 2009, J LIPID RES, V50, pS382, DOI 10.1194/jlr.R800032-JLR200
   Skinner AC, 2015, NEW ENGL J MED, V373, P1307, DOI 10.1056/NEJMoa1502821
   Steinberger J, 2009, CIRCULATION, V119, P628, DOI 10.1161/CIRCULATIONAHA.108.191394
   Suganami T, 2005, ARTERIOSCL THROM VAS, V25, P2062, DOI 10.1161/01.ATV.0000183883.72263.13
   Tan SX, 2015, J BIOL CHEM, V290, P11337, DOI 10.1074/jbc.M114.623686
   Thomas A, 2016, SCI REP-UK, V6, DOI 10.1038/srep24618
   Thota P, 2017, GYNECOL ENDOCRINOL, V33, P179, DOI 10.1080/09513590.2016.1273897
   Togashi K, 2002, INT J OBESITY, V26, P770, DOI 10.1038/sj.ijo.0801992
   Umer A, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4691-z
   Viner R, 2017, LANCET, V389, P2252, DOI 10.1016/S0140-6736(17)31371-5
   Walter P, 2011, SCIENCE, V334, P1081, DOI 10.1126/science.1209038
   Wang NN, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0188007
   Wang S, 2017, Zhonghua Yu Fang Yi Xue Za Zhi, V51, P300, DOI 10.3760/cma.j.issn.0253-9624.2017.04.005
   WEBBER LS, 1991, AM J EPIDEMIOL, V133, P884, DOI 10.1093/oxfordjournals.aje.a115968
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Wellen KE, 2003, J CLIN INVEST, V112, P1785, DOI 10.1172/JCI20514
   Williams H, 2017, INT ANGIOL, V36, P145, DOI 10.23736/S0392-9590.16.03661-0
   Withers DJ, 2000, ENDOCRINOLOGY, V141, P1917, DOI 10.1210/en.141.6.1917
   Xiao CT, 2011, DIABETES, V60, P918, DOI 10.2337/db10-1433
   Yan Yinkun, 2016, Zhonghua Yu Fang Yi Xue Za Zhi, V50, P34, DOI 10.3760/cma.j.issn.0253-9624.2016.01.007
   Yan Yinkun, 2016, Zhonghua Yu Fang Yi Xue Za Zhi, V50, P28, DOI 10.3760/cma.j.issn.0253-9624.2016.01.006
   Yorimitsu T, 2006, J BIOL CHEM, V281, P30299, DOI 10.1074/jbc.M607007200
   You BS, 2008, DIABETES, V57, P372, DOI 10.2337/db07-1045
   Zhou J, 2005, CIRCULATION, V111, P1814, DOI 10.1161/01.CIR.0000160864.31351.C1
   Zhou LJ, 2009, MOL PHARMACOL, V76, P596, DOI 10.1124/mol.109.057067
NR 95
TC 1
Z9 1
U1 0
U2 7
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2019
VL 12
IS 4
BP 3095
EP 3106
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HW2DW
UT WOS:000466494200007
DA 2025-06-11
ER

PT J
AU Schraplau, A
   Block, A
   Häusler, A
   Wippert, PM
   Rapp, MA
   Völler, H
   Bonaventura, K
   Mayer, F
AF Schraplau, Anne
   Block, Andrea
   Haeusler, Andreas
   Wippert, Pia-Maria
   Rapp, Michael A.
   Voeller, Heinz
   Bonaventura, Klaus
   Mayer, Frank
TI Mobile diagnostics and consultation for the prevention of the metabolic
   syndrome and its secondary diseases in Brandenburg-study protocol of a
   regional prospective cohort study: the Mobile Brandenburg Cohort
SO PILOT AND FEASIBILITY STUDIES
LA English
DT Article
DE Metabolic syndrome; Mobile diagnostics; Prevention; Nutrition; Physical
   activity; Rural health
ID PHYSICAL-ACTIVITY; WOMEN; CARE; PREVALENCE; VALIDATION; DEPRESSION;
   MORTALITY; SEVERITY; HEALTH; TRENDS
AB Background: The metabolic syndrome (MetS) is a risk cluster for a number of secondary diseases. The implementation of prevention programs requires early detection of individuals at risk. However, access to health care providers is limited in structurally weak regions. Brandenburg, a rural federal state in Germany, has an especially high MetS prevalence and disease burden. This study aims to validate and test the feasibility of a setup for mobile diagnostics of MetS and its secondary diseases, to evaluate the MetS prevalence and its association with moderating factors in Brandenburg and to identify new ways of early prevention, while establishing a "Mobile Brandenburg Cohort" to reveal new causes and risk factors for MetS.
   Methods: In a pilot study, setups for mobile diagnostics of MetS and secondary diseases will be developed and validated. A van will be equipped as an examination room using point-of-care blood analyzers and by mobilizing standard methods. In study part A, these mobile diagnostic units will be placed at different locations in Brandenburg to locally recruit 5000 participants aged 40-70 years. They will be examined for MetS and advice on nutrition and physical activity will be provided. Questionnaires will be used to evaluate sociodemographics, stress perception, and physical activity. In study part B, participants with MetS, but without known secondary diseases, will receive a detailed mobile medical examination, including MetS diagnostics, medical history, clinical examinations, and instrumental diagnostics for internal, cardiovascular, musculoskeletal, and cognitive disorders. Participants will receive advice on nutrition and an exercise program will be demonstrated on site. People unable to participate in these mobile examinations will be interviewed by telephone. If necessary, participants will be referred to general practitioners for further diagnosis.
   Discussion: The mobile diagnostics approach enables early detection of individuals at risk, and their targeted referral to local health care providers. Evaluation of the MetS prevalence, its relation to risk-increasing factors, and the "Mobile Brandenburg Cohort" create a unique database for further longitudinal studies on the implementation of home-based prevention programs to reduce mortality, especially in rural regions.
C1 [Schraplau, Anne; Mayer, Frank] Univ Potsdam, Univ Outpatient Clin Sports Med & Sports Orthoped, Neuen Palais 10, D-14469 Potsdam, Germany.
   [Schraplau, Anne; Wippert, Pia-Maria; Rapp, Michael A.; Voeller, Heinz; Mayer, Frank] Univ Potsdam, Fac Hlth Sci Brandenburg, Potsdam, Germany.
   [Block, Andrea; Wippert, Pia-Maria] Univ Potsdam, Med Sociol & Psychobiol, Potsdam, Germany.
   [Haeusler, Andreas; Rapp, Michael A.] Univ Potsdam, Social & Prevent Med, Potsdam, Germany.
   [Voeller, Heinz] Univ Potsdam, Rehabil Med, Potsdam, Germany.
   [Voeller, Heinz] Rehabil Ctr Internal Med, Klin See, Rudersdorf, Germany.
   [Bonaventura, Klaus] Ernst von Bergmann Clin, Internal Med Cardiol, Potsdam, Germany.
C3 University of Potsdam; University of Potsdam; University of Potsdam;
   University of Potsdam; University of Potsdam; Klinikum Ernst von
   Bergmann
RP Schraplau, A (corresponding author), Univ Potsdam, Univ Outpatient Clin Sports Med & Sports Orthoped, Neuen Palais 10, D-14469 Potsdam, Germany.; Schraplau, A (corresponding author), Univ Potsdam, Fac Hlth Sci Brandenburg, Potsdam, Germany.
EM anne.schraplau@uni-potsdam.de
RI Rapp, Michael/ABB-7573-2020; Wippert, Pia-Maria/AAJ-6989-2020
OI Rapp, Michael/0000-0003-0106-966X; Block, Andrea/0000-0002-4819-2529;
   Wippert, Pia-Maria/0000-0001-7221-4073
FU Ministry of Science, Research and Culture (MWFK) of the Federal State of
   Brandenburg (Germany) [85000956]; Projekt DEAL; European Union (European
   Regional Development Fund, ERDF) within the program "Starkung der
   technologischen und anwendungsnahen Forschung an
   Wissenschaftseinrichtungen (StaF-RL)" [85000956]
FX The study is funded by the Ministry of Science, Research and Culture
   (MWFK) of the Federal State of Brandenburg (Germany) with resources from
   the European Union (European Regional Development Fund, ERDF) within the
   program "Starkung der technologischen und anwendungsnahen Forschung an
   Wissenschaftseinrichtungen (StaF-RL)" [Reference: 85000956, Grant
   authority: Investitionsbank des Landes Brandenburg (ILB)]. The funders
   played no role in the design of the study. Open Access funding enabled
   and organized by Projekt DEAL.
CR Advisory Counsil on the assessment of developments in the health care system, 2014, NEEDS BAS HLTH CAR O
   Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Anderson TJ, 2015, BMC HEALTH SERV RES, V15, DOI 10.1186/s12913-015-1053-3
   [Anonymous], 2016, Official Journal of the European Union, L, V119, P1
   [Anonymous], 2013, Health 2020, A European policy framework and strategy for the 21st century
   [Anonymous], 2013, Global health workforce shortage to reach 12.9 million in coming decades
   Bennett JE, 2018, LANCET, V392, P1072, DOI 10.1016/S0140-6736(18)31992-5
   Bjarnason-Wehrens B., 2009, CLIN RES CARDIOLOGY, V4, P1, DOI [10.1007/s11789-009-, DOI 10.1007/S11789-009]
   CHARLSON ME, 1987, J CHRON DIS, V40, P373, DOI 10.1016/0021-9681(87)90171-8
   Cleeland CS., 1989, ADV PAIN RES THER, V12, p391?03
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Cook SE, 2009, J GERIATR PSYCH NEUR, V22, P103, DOI 10.1177/0891988708328214
   Cooper C, 2015, AM J PSYCHIAT, V172, P323, DOI 10.1176/appi.ajp.2014.14070878
   Courties A, 2017, CURR OPIN RHEUMATOL, V29, P214, DOI 10.1097/BOR.0000000000000373
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   Danish A, 2019, RURAL REMOTE HEALTH, V19, DOI 10.22605/RRH5466
   de la Iglesia R, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17111877
   DESTATIS, 2009, GES VERH RAUCHG ALT
   Deutscher Herzbericht, 2018, SEKT VERS KARD HERZC
   Dragsbæk K, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000004806
   Driver SL, 2016, J AM COLL CARDIOL, V67, P1227, DOI 10.1016/j.jacc.2015.12.047
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   DURNIN JVGA, 1974, BRIT J NUTR, V32, P77, DOI 10.1079/BJN19740060
   Gaida JE, 2009, MED SCI SPORT EXER, V41, P1194, DOI 10.1249/MSS.0b013e31819794c3
   Goffrier MA., 2017, MONIT VERSORGUNGSFOR, V10, P46, DOI [10.24945/MVF.05.17.1866-0533.2040, DOI 10.24945/MVF.05.17.1866-0533.2040]
   Grabe HJ, 2012, PSYCHIAT PRAX, V39, P109, DOI 10.1055/s-0031-1298984
   Green LV, 2013, HEALTH AFFAIR, V32, P11, DOI 10.1377/hlthaff.2012.1086
   Heidemann C., 2022, J Health Monitoring, V2, P48, DOI [10.17886/RKI-GBE-2017-008, DOI 10.17886/RKI-GBE-2017-008, 10.25646/10292, DOI 10.25646/10292]
   Isaksson RM, 2008, EUR J CARDIOVASC NUR, V7, P152, DOI 10.1016/j.ejcnurse.2007.09.001
   Jungvogel A., 2013, Ernhrungs Umschau, V11, P644
   Kassenarztliche Bundesvereinigung, 2019, STAT INF BUND
   Krishna S, 2010, J RURAL HEALTH, V26, P3, DOI 10.1111/j.1748-0361.2009.00259.x
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Kroenke K, 2009, J AFFECT DISORDERS, V114, P163, DOI 10.1016/j.jad.2008.06.026
   Kuhn B, 2017, BMC FAM PRACT, V18, DOI 10.1186/s12875-017-0696-z
   Lakka TA, 2007, APPL PHYSIOL NUTR ME, V32, P76, DOI 10.1139/h06-113
   Langsted A, 2019, PATHOLOGY, V51, P131, DOI 10.1016/j.pathol.2018.09.062
   Lee RE, 1997, ANN BEHAV MED, V19, P378, DOI 10.1007/BF02895157
   Moebus S, 2008, DTSCH ARZTEBL INT, V105, P207, DOI 10.3238/artzebl.2008.0207
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Nasreddine ZS, 2005, J AM GERIATR SOC, V53, P695, DOI 10.1111/j.1532-5415.2005.53221.x
   Nolan Paul B, 2017, Prev Med Rep, V7, P211, DOI 10.1016/j.pmedr.2017.07.004
   Parizkova J, 1974, Adv Exp Med Biol, V49, P119
   Puth MT, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4833-3
   Radbruch L, 1999, J PAIN SYMPTOM MANAG, V18, P180, DOI 10.1016/S0885-3924(99)00064-0
   Rattinger H., 2011, 2011 GESIS DATA ARCH
   Rizza A, 2012, BMC FAM PRACT, V13, DOI 10.1186/1471-2296-13-113
   RYFF CD, 1995, J PERS SOC PSYCHOL, V69, P719
   Salzwedel A, 2018, DEUT MED WOCHENSCHR, V143, pE51, DOI 10.1055/s-0043-123907
   Schipf S, 2010, DIABETOL STOFFWECHS, V5, P161, DOI 10.1055/s-0030-1247406
   Schröder L, 2018, BMC FAM PRACT, V19, DOI 10.1186/s12875-018-0733-6
   Schulz U, 2003, DIAGNOSTICA, V49, P73, DOI 10.1026//0012-1924.49.2.73
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Stentzel U, 2016, BMC HEALTH SERV RES, V16, DOI 10.1186/s12913-016-1839-y
   van den Berg N, 2012, BMC HEALTH SERV RES, V12, DOI 10.1186/1472-6963-12-355
   Villapiano N, 2017, J AM BOARD FAM MED, V30, P816, DOI 10.3122/jabfm.2017.06.170137
   VONKORFF M, 1992, PAIN, V50, P133, DOI 10.1016/0304-3959(92)90154-4
   WATSON D, 1988, J PERS SOC PSYCHOL, V54, P1063, DOI 10.1037/0022-3514.54.6.1063
   WHO, 2011, WORLD REPORT ON DISABILITY, P1
   WHO, 2015, GLOB REC PHYS ACT HL
   Wippert PM, 2017, PAIN REP, V2, DOI 10.1097/PR9.0000000000000623
   Wippert PM, 2017, J PAIN RES, V10, P1569, DOI 10.2147/JPR.S134976
   Yki-Järvinen H, 2014, LANCET DIABETES ENDO, V2, P901, DOI 10.1016/S2213-8587(14)70032-4
NR 63
TC 0
Z9 0
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2055-5784
J9 PILOT FEASIBILITY ST
JI Pilot Feasibility Stud.
PD AUG 30
PY 2021
VL 7
IS 1
AR 166
DI 10.1186/s40814-021-00898-w
PG 11
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA UL6CD
UT WOS:000692736200001
PM 34462012
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Korycka-Bloch, R
   Balicki, P
   Guligowska, A
   Soltysik, BK
   Kostka, T
   Chrzastek, Z
AF Korycka-Bloch, Renata
   Balicki, Pawel
   Guligowska, Agnieszka
   Soltysik, Bartlomiej K.
   Kostka, Tomasz
   Chrzastek, Zuzanna
TI Weight-Adjusted Waist Index (WWI)-A Promising Anthropometric Indicator
   of Depressive Symptoms in Hospitalized Older Patients
SO NUTRIENTS
LA English
DT Article
DE WWI; BMI; depressive symptoms; older adults
ID BODY-MASS INDEX; INSTRUMENTAL ACTIVITIES; OBESITY; ASSOCIATION; RISK;
   PEOPLE; DYSLIPIDEMIA; HYPERTENSION; OSTEOPOROSIS
AB Objectives: The aim of this study was to evaluate which anthropometric index, either body mass index (BMI) or weight-adjusted waist index (WWI), is more accurately associated with the prevalence of the most common chronic diseases and components of geriatric assessment in hospitalized older adults. Methods: The study included a total of 2945 hospitalized older adults (median age 82 years). The associations between the presence of chronic diseases and Comprehensive Geriatric Assessment (CGA) results were compared with WWI and BMI values. Results: The WWI was significantly higher in both sex groups suffering from hypertension, diabetes, osteoarthritis, and depression. In women, the parameter was increased among individuals with previous myocardial infarction, who presented heart failure symptoms or had chronic kidney disease diagnosed, whereas in men, among those with pulmonary diseases and osteoporosis, WWI was related to many CGA parameters oftentimes where BMI proved to fail. There was a positive correlation of WWI with the presence of depressive symptoms assessed with the geriatric depression scale (GDS) but no significant correlation with BMI. In multiple logistic regression models, WWI was a stronger predictor of depression as compared to waist circumference or the waist-to-height ratio. Conclusions: There is an association between a higher WWI and depression diagnosis as well as the presence of depressive symptoms according to the GDS in hospitalized older adults, both women and men. There is no such correlation between depression and BMI. Both high BMI and high WWI values seem to identify older patients with cardiometabolic diseases such as hypertension and diabetes. According to this study, WWI seems to be a promising indicator of depression risk and, similarly to BMI, a useful parameter for the assessment of cardiometabolic risk in older hospitalized adults.
C1 [Korycka-Bloch, Renata; Balicki, Pawel; Guligowska, Agnieszka; Soltysik, Bartlomiej K.; Kostka, Tomasz; Chrzastek, Zuzanna] Med Univ Lodz, Hlth Ageing Res Ctr, Dept Geriatr, PL-92209 Lodz, Poland.
C3 Medical University Lodz
RP Chrzastek, Z (corresponding author), Med Univ Lodz, Hlth Ageing Res Ctr, Dept Geriatr, PL-92209 Lodz, Poland.
EM renata.korycka-bloch@umed.lodz.pl; pawel.balicki@umed.lodz.pl;
   agnieszka.guligowska@umed.lodz.pl; bartlomiej.soltysik@umed.lodz.pl;
   tomasz.kostka@umed.lodz.pl; zuzanna.chrzastek@umed.lodz.pl
RI Guligowska, Agnieszka/AAS-6207-2020; Soltysik, Bartlomiej K./S-9839-2016
OI Balicki, Pawel/0009-0007-7688-3865; Guligowska,
   Agnieszka/0000-0002-6928-3892; Soltysik, Bartlomiej
   K./0000-0002-1382-3757; Chrzastek, Zuzanna/0000-0001-9562-178X; Kostka,
   Tomasz/0000-0003-0437-650X
FU Medical University of Lodz, Poland;  [503/6-077-01/503-61-001]
FX The authors were supported by grant No. 503/6-077-01/503-61-001 from the
   Medical University of Lodz, Poland.
CR [Anonymous], 2017, World Health Organization Newsroom Fact Sheet
   Aprahamian Ivan, 2009, Dement. neuropsychol., V3, P74
   Arévalo SP, 2020, J AM GERIATR SOC, V68, P882, DOI 10.1111/jgs.16300
   Badillo N, 2022, CUREUS J MED SCIENCE, V14, DOI 10.7759/cureus.21841
   Batsis JA, 2014, EUR J INTERN MED, V25, P517, DOI 10.1016/j.ejim.2014.05.008
   Bays HE, 2007, INT J CLIN PRACT, V61, P737, DOI 10.1111/j.1742-1241.2007.01336.x
   Cai S, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.894686
   Compston JE, 2014, J BONE MINER RES, V29, P487, DOI 10.1002/jbmr.2051
   Danat IM, 2019, J ALZHEIMERS DIS, V70, pS87, DOI 10.3233/JAD-180763
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   De Lorenzo A, 2022, NUTRIENTS, V14, DOI 10.3390/nu14245295
   Feely O, 2022, AGE AGEING, V51, DOI 10.1093/ageing/afac218.105
   Gandham A, 2020, BONE, V140, DOI 10.1016/j.bone.2020.115546
   Greco EA, 2010, INT J CLIN PRACT, V64, P817, DOI 10.1111/j.1742-1241.2009.02301.x
   Hägg S, 2015, INT J EPIDEMIOL, V44, P578, DOI 10.1093/ije/dyv094
   Haththotuwa RN, 2013, ELSEV INSIGHT, P3, DOI 10.1016/B978-0-12-416045-3.00001-7
   Heissel A, 2023, BRIT J SPORT MED, V57, P1049, DOI 10.1136/bjsports-2022-106282
   Ishii S, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0162898
   Jia SS, 2024, J NUTR HEALTH AGING, V28, DOI 10.1016/j.jnha.2024.100356
   Jia SS, 2024, J NUTR HEALTH AGING, V28, DOI 10.1016/j.jnha.2024.100222
   KATZ S, 1983, J AM GERIATR SOC, V31, P721, DOI 10.1111/j.1532-5415.1983.tb03391.x
   Kenchaiah S, 2002, NEW ENGL J MED, V347, P305, DOI 10.1056/NEJMoa020245
   Kenchaiah S, 2009, CIRCULATION, V119, P44, DOI 10.1161/CIRCULATIONAHA.108.807289
   Khonsari NM, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.857930
   Kim JE, 2023, BRIT J NUTR, V129, P875, DOI 10.1017/S0007114522001817
   Kim KJ, 2023, J CACHEXIA SARCOPENI, V14, P2196, DOI 10.1002/jcsm.13302
   Kim NH, 2021, AGE AGEING, V50, P780, DOI 10.1093/ageing/afaa208
   Kondrup J, 2003, CLIN NUTR, V22, P321, DOI 10.1016/S0261-5614(02)00214-5
   Larsson SC, 2020, EUR HEART J, V41, P221, DOI 10.1093/eurheartj/ehz388
   LAWTON MP, 1969, GERONTOLOGIST, V9, P179, DOI 10.1093/geront/9.3_Part_1.179
   Leszczak J, 2024, SCI REP-UK, V14, DOI 10.1038/s41598-024-52009-3
   Li JX, 2024, FRONT NUTR, V11, DOI 10.3389/fnut.2024.1390282
   Li M, 2024, J AFFECT DISORDERS, V347, P299, DOI 10.1016/j.jad.2023.11.073
   Li XW, 2023, BMC NEPHROL, V24, DOI 10.1186/s12882-023-03316-w
   Li ZZ, 2022, J CACHEXIA SARCOPENI, V13, P128, DOI 10.1002/jcsm.12908
   Liu HY, 2024, J AFFECT DISORDERS, V350, P49, DOI 10.1016/j.jad.2024.01.104
   Liu SB, 2024, BMC GERIATR, V24, DOI 10.1186/s12877-024-05339-w
   Luo JH, 2024, J NUTR HEALTH AGING, V28, DOI 10.1016/j.jnha.2024.100322
   Lynch DH, 2022, J AM GERIATR SOC, V70, P1442, DOI 10.1111/jgs.17683
   Makovski TT, 2019, AGEING RES REV, V53, DOI 10.1016/j.arr.2019.04.005
   Mi BG, 2024, J ORTHOP SURG-HONG K, V32, DOI 10.1177/10225536241268827
   Muhammad T, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-17518-z
   Nguyen NT, 2008, J AM COLL SURGEONS, V207, P928, DOI 10.1016/j.jamcollsurg.2008.08.022
   Noh JW, 2015, BMC PUBLIC HEALTH, V15, DOI 10.1186/s12889-015-1663-z
   Organization WH, 2022, Ageing and Health
   Ozkok S, 2022, CLIN NUTR, V41, P2509, DOI 10.1016/j.clnu.2022.09.005
   Park Y, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-35073-4
   Petermann-Rocha F, 2022, J CACHEXIA SARCOPENI, V13, P86, DOI 10.1002/jcsm.12783
   Proietto Joseph, 2020, F1000Res, V9, DOI 10.12688/f1000research.20875.1
   Qin Z, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.941926
   Roh E, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00332
   Saliba D, 2001, J AM GERIATR SOC, V49, P1691, DOI 10.1046/j.1532-5415.2001.49281.x
   de Oliveira LDSCB, 2019, TRENDS PSYCHIATR PSY, V41, P36, DOI 10.1590/2237-6089-2017-0129
   Shen Y, 2024, J AFFECT DISORDERS, V355, P299, DOI 10.1016/j.jad.2024.03.143
   Sun F, 2024, ENDOCR CONNECT, V13, DOI 10.1530/EC-23-0450
   Sun HX, 2023, FAM PRACT, V40, P782, DOI 10.1093/fampra/cmad047
   Trivedi D, 2017, PRIM HEALTH CARE RES, V18, P527, DOI 10.1017/S1463423617000202
   Wang J, 2023, FRONT PUBLIC HEALTH, V11, DOI 10.3389/fpubh.2023.1210669
   Wang XH, 2023, BMC MUSCULOSKEL DIS, V24, DOI 10.1186/s12891-023-06717-y
   Wang XL, 2024, AGING CLIN EXP RES, V36, DOI 10.1007/s40520-023-02649-8
   Wild B, 2012, J PSYCHOSOM RES, V72, P376, DOI 10.1016/j.jpsychores.2012.01.019
   Xiang XL, 2015, J PSYCHOSOM RES, V78, P242, DOI 10.1016/j.jpsychores.2014.12.008
   YESAVAGE JA, 1983, J PSYCHIATR RES, V17, P37, DOI 10.1016/0022-3956(82)90033-4
   Yu SS, 2023, J CLIN MED, V12, DOI 10.3390/jcm12041620
   Zhang DL, 2022, FRONT CARDIOVASC MED, V9, DOI 10.3389/fcvm.2022.1069146
   Zheng DD, 2024, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1325454
   Zhou HJ, 2024, SCI REP-UK, V14, DOI 10.1038/s41598-024-61928-0
NR 67
TC 1
Z9 1
U1 6
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2025
VL 17
IS 1
AR 68
DI 10.3390/nu17010068
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA R8G9P
UT WOS:001393776500001
PM 39796502
OA gold
DA 2025-06-11
ER

PT J
AU Nakashiki, K
   Kisanuki, A
   Otsuji, Y
   Yoshifuku, S
   Yuasa, T
   Takasaki, K
   Kuwahara, E
   Yu, B
   Uemura, T
   Mizukami, N
   Hamasaki, S
   Minagoe, S
   Tei, C
AF Nakashiki, Kenichi
   Kisanuki, Akira
   Otsuji, Yutaka
   Yoshifuku, Shiro
   Yuasa, Toshinori
   Takasaki, Kunitsugu
   Kuwahara, Eiji
   Yu, Bo
   Uemura, Takeshi
   Mizukami, Naoko
   Hamasaki, Shuichi
   Minagoe, Shinichi
   Tei, Chuwa
TI Usefulness of a novel ultrasound transducer for continuous monitoring
   treadmill exercise echocardiography to assess coronary artery disease
SO CIRCULATION JOURNAL
LA English
DT Article
DE coronary artery disease; stress echocardiography; treadmill exercise
   test
ID DOBUTAMINE STRESS ECHOCARDIOGRAPHY; SUPINE BICYCLE EXERCISE; ISCHEMIC
   CASCADE; SYNDROME-X; MYOCARDIUM; REST
AB Background The feasibility of a novel ultrasound probe, which can be attached to the left ventricular (LV) apex chest wall and allows free rotation around its long axis direction for the continuous monitoring of LV wall motion, was tested.
   Methods and Results There were 36 subjects who had coronary artery disease (CAD). By attaching a novel ultrasound probe to the chest wall, the LV apical views were recorded during treadmill exercise stress echocardiography (Echo). The continuous monitoring of LV wall motion was satisfactorily feasible in 30 of 36 patients. The visualization rate of the overall LV segments was higher at rest (90%) compared to that during peak exercise (77%). The segments were better visualized in apical portions (90-400%) than in mid (77-96%) or basal portions (68-87%). The sensitivity, specificity, and accuracy for detecting CAD were 61, 100 and 77%, respectively. The wall motion score index 3 and 6 min after exercise decreased significantly compared to those at peak exercise. The number of segments with dyssynergy was highest at the peak exercise. Ischemic ST-T depression on electrocardiography was observed only at peak stress periods.
   Conclusions Continuous monitoring treadmill exercise Echo using a novel ultrasound probe seems feasible for the non-invasive and physiological assessment of CAD.
C1 Kagoshima Univ Hosp, Dept Cardiovasc Med, Kagoshima, Japan.
C3 Kagoshima University
RP Nakashiki, K (corresponding author), Kagoshima Univ, Grad Sch Med, Dept Cardiovasc Resp & Metab Med, 8-35-1 Sakuragaoka, Kagoshima 8908520, Japan.
EM kenchan@js7.so-net.ne.jp
RI Kuwahara, Eiji/AAH-4106-2019
CR Armstrong WF, 1997, EUR HEART J, V18, pD2
   ASUTEN WG, 1975, CIRCULATION S, V51, P5
   Badruddin SM, 1999, J AM COLL CARDIOL, V33, P1485, DOI 10.1016/S0735-1097(99)00043-1
   Chandraratna PAN, 2003, ECHOCARDIOGR-J CARD, V20, P491, DOI 10.1046/j.1540-8175.2003.03084.x
   Chandraratna PAN, 2002, J AM SOC ECHOCARDIOG, V15, P1381, DOI 10.1067/mje.2002.125921
   Chandraratna PAN, 2001, ECHOCARDIOGR-J CARD, V18, P651, DOI 10.1046/j.1540-8175.2001.00651.x
   Dagianti A, 1997, CIRCULATION, V95, P1176
   Dagianti A, 1998, AM J CARDIOL, V81, p62G, DOI 10.1016/S0002-9149(98)00056-3
   Feigembaum H., 1994, ECHOCARDIOGR-J CARD, P457
   HANSEN JE, 1984, AM REV RESPIR DIS, V129, pS25, DOI 10.1164/arrd.1984.129.2P2.S25
   Hecht H S, 1993, J Am Soc Echocardiogr, V6, P265
   Hoffmann R, 1998, AM J CARDIOL, V82, P1520, DOI 10.1016/S0002-9149(98)00697-3
   HOMANS DC, 1991, CIRCULATION, V83, P2029, DOI 10.1161/01.CIR.83.6.2029
   Hung MJ, 2006, CIRC J, V70, P254, DOI 10.1253/circj.70.254
   Hyodo E, 2003, CIRC J, V67, P406
   ISKANDRIAN AS, 1989, J AM COLL CARDIOL, V14, P1477, DOI 10.1016/0735-1097(89)90385-9
   Kim MH, 2005, CIRC J, V69, P39, DOI 10.1253/circj.69.39
   KLONER RA, 1991, AM J CARDIOL, V68, P329, DOI 10.1016/0002-9149(91)90827-8
   Leong-Poi H, 2002, CIRCULATION, V105, P987, DOI 10.1161/hc0802.104326
   LIMACHER MC, 1983, CIRCULATION, V67, P1211, DOI 10.1161/01.CIR.67.6.1211
   MARWICK TH, 1992, J AM COLL CARDIOL, V19, P74, DOI 10.1016/0735-1097(92)90054-Q
   MARWICK TH, 1995, J AM COLL CARDIOL, V26, P335, DOI 10.1016/0735-1097(95)80004-Z
   MARWICK TH, 1995, J AM COLL CARDIOL, V26, P1180, DOI 10.1016/0735-1097(96)81472-0
   Modesto KM, 2003, AM J CARDIOL, V91, P1245, DOI 10.1016/S0002-9149(03)00275-3
   NESTO RW, 1987, AM J CARDIOL, V57, P23
   NIHOYANNOPOULOS P, 1991, J AM COLL CARDIOL, V18, P1463, DOI 10.1016/0735-1097(91)90676-Z
   Panza JA, 1997, J AM COLL CARDIOL, V29, P293, DOI 10.1016/S0735-1097(96)00481-0
   Peteiro J, 2004, J AM SOC ECHOCARDIOG, V17, P1044, DOI 10.1016/j.echo.2004.06.002
   Peteiro J, 2003, Eur J Echocardiogr, V4, P182, DOI 10.1016/S1525-2167(02)00168-3
   Peteiro J, 1999, J AM SOC ECHOCARDIOG, V12, P1073, DOI 10.1016/S0894-7317(99)70104-5
   PICANO E, 1987, AM J CARDIOL, V60, P508, DOI 10.1016/0002-9149(87)90295-5
   Picano E, 1999, Cardiologia, V44, P791
   Presti C F, 1988, J Am Soc Echocardiogr, V1, P119
   ROBERTSON WS, 1983, J AM COLL CARDIOL, V2, P1085, DOI 10.1016/S0735-1097(83)80334-9
   ROGER VL, 1994, J AM COLL CARDIOL, V24, P109, DOI 10.1016/0735-1097(94)90549-5
   Roger VL, 1997, CIRCULATION, V95, P405
   Ryan T, 1993, J Am Soc Echocardiogr, V6, P186
   RYAN T, 1988, J AM COLL CARDIOL, V11, P993, DOI 10.1016/S0735-1097(98)90056-0
   Schiller N B, 1989, J Am Soc Echocardiogr, V2, P358
   Tani T, 2004, CIRC J, V68, P950, DOI 10.1253/circj.68.950
   Vahdat A, 2002, ECHOCARDIOGR-J CARD, V19, P325, DOI 10.1046/j.1540-8175.2002.00325.x
NR 41
TC 5
Z9 7
U1 0
U2 0
PU JAPANESE CIRCULATION SOC
PI TOYKO
PA 18TH FLOOR IMPERIAL HOTEL TOWER, 1-1-1 UCHISAIWAI-CHO CHIYODA-KU, TOYKO,
   100-0011, JAPAN
SN 1346-9843
EI 1347-4820
J9 CIRC J
JI Circ. J.
PD OCT
PY 2006
VL 70
IS 10
BP 1297
EP 1302
DI 10.1253/circj.70.1297
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 089VC
UT WOS:000240908400011
PM 16998262
OA Bronze
DA 2025-06-11
ER

PT J
AU Suzuki, M
   Kon, K
   Ikejima, K
   Arai, K
   Uchiyama, A
   Aoyama, T
   Yamashina, S
   Ueno, T
   Watanabe, S
AF Suzuki, Maiko
   Kon, Kazuyoshi
   Ikejima, Kenichi
   Arai, Kumiko
   Uchiyama, Akira
   Aoyama, Tomonori
   Yamashina, Shunhei
   Ueno, Takashi
   Watanabe, Sumio
TI The Chemical Chaperone 4-Phenylbutyric Acid Prevents Alcohol-Induced
   Liver Injury in Obese KK-A<SUP>y</SUP> Mice
SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Article
DE Alcoholic Liver Disease; Obesity; Metabolic Syndrome; Endoplasmic
   Reticulum Stress; Oxidative Stress
ID ENDOPLASMIC-RETICULUM STRESS; CLINICAL-PRACTICE GUIDELINES; SHORT-TERM
   SURVIVAL; FATTY LIVER; ER-STRESS; OXIDATIVE STRESS; METABOLIC
   STEATOHEPATITIS; DIETARY STEATOHEPATITIS; CYTOCHROME P4502E1; MOUSE
   MODEL
AB Background Co-occurrence of metabolic syndrome and chronic alcohol consumption is increasing worldwide. The present study investigated the effect of the chemical chaperone 4-phenylbutyric acid (PBA)-which has been shown to alleviate dietary steatohepatitis caused by endoplasmic reticulum (ER) stress-on chronic-plus-binge ethanol (EtOH)-induced liver injury in a mouse model of obesity. Methods Male KK-A(y) mice (8 weeks old) were fed a Lieber-DeCarli diet (5% EtOH) for 10 days. Some mice were given PBA intraperitoneally (120 mg/kg body weight, daily) during the experimental period. On day 11, mice were gavaged with a single dose of EtOH (4 g/kg body weight). Control mice were given a dextrin gavage after being pair-fed a control diet. All mice were then serially euthanized before or at 9 hours after gavage. Results Chronic-plus-binge EtOH intake induced massive hepatic steatosis along with hepatocyte apoptosis and inflammation, which was reversed by PBA treatment. Administration of PBA also suppressed chronic-plus-binge EtOH-induced up-regulation of ER stress-related genes including binding immunoglobulin protein (Bip), unspliced and spliced forms of X-box-binding protein-1 (uXBP1 and sXBP1, respectively), inositol trisphosphate receptor (IP3R), and C/EBP homologous protein (CHOP). Further, it blocked chronic-plus-binge EtOH-induced expression of the oxidative stress marker heme oxygenase-1 (HO-1) and 4-hydroxynonenal. Chronic EtOH alone (without binge) increased Bip and uXBP1, but it did not affect those of sXBP1, IP3R, CHOP, or HO-1. PBA reversed the prebinge expression of these genes to control levels, but it did not affect chronic EtOH-induced hepatic activity of cytochrome P450 2E1. Conclusions Binge EtOH intake after chronic consumption induces massive ER stress-related oxidative stress and liver injury in a mouse model of obesity through dysregulation of the unfolded protein response. PBA ameliorated chronic-plus-binge EtOH-induced liver injury by reducing ER and oxidative stress after an EtOH binge.
C1 [Suzuki, Maiko; Kon, Kazuyoshi; Ikejima, Kenichi; Arai, Kumiko; Uchiyama, Akira; Aoyama, Tomonori; Yamashina, Shunhei; Watanabe, Sumio] Juntendo Univ, Grad Sch Med, Dept Gastroenterol, Tokyo, Japan.
   [Ueno, Takashi] Juntendo Univ, Lab Prote & Med Sci, Res Support Ctr, Lab Prote & Biomol Sci, Tokyo, Japan.
C3 Juntendo University; Juntendo University
RP Kon, K (corresponding author), Juntendo Univ, Grad Sch Med, Dept Gastroenterol, Bunkyo Ku, 2-1-1 Hongo, Tokyo 1138421, Japan.
EM kazukon@juntendo.ac.jp
RI Kon, Kazuyoshi/AAV-7832-2020
OI Kon, Kazuyoshi/0000-0002-1127-2218
FU Japan Society for the Promotion of Science KAKENHI [15K09023, 16H05293];
   [28-39]; Grants-in-Aid for Scientific Research [16H05293, 15K09023]
   Funding Source: KAKEN
FX This work was supported in part by the Japan Society for the Promotion
   of Science KAKENHI (no. 15K09023 to KI and no. 16H05293 to SW) and a
   grant for Cross-disciplinary Collaboration, Juntendo University (no.
   28-39).
CR Abdelmegeed MA, 2013, FREE RADICAL BIO MED, V65, P1238, DOI 10.1016/j.freeradbiomed.2013.09.009
   Adachi T, 2014, J CLIN BIOCHEM NUTR, V54, P129, DOI 10.3164/jcbn.13-46
   Akriviadis E, 2000, GASTROENTEROLOGY, V119, P1637, DOI 10.1053/gast.2000.20189
   Almeda-Valdes P, 2016, REV RECENT CLIN TRIA, V11, P220, DOI 10.2174/1574887111666160815102725
   Back SH, 2009, CELL METAB, V10, P13, DOI 10.1016/j.cmet.2009.06.002
   Bergheim I, 2005, DIGEST DIS, V23, P275, DOI 10.1159/000090175
   Bertola A, 2013, NAT PROTOC, V8, P627, DOI 10.1038/nprot.2013.032
   Cederbaum AI, 2014, REDOX BIOL, V2, P1048, DOI 10.1016/j.redox.2014.09.007
   Cederbaum AI, 2012, CLIN LIVER DIS, V16, P667, DOI 10.1016/j.cld.2012.08.002
   Dara L, 2011, HEPATOLOGY, V53, P1752, DOI 10.1002/hep.24279
   Fernandez A, 2013, J HEPATOL, V59, P805, DOI 10.1016/j.jhep.2013.05.023
   Gülow K, 2002, J CELL SCI, V115, P2443
   Gurlo T, 2016, MOL ENDOCRINOL, V30, P446, DOI 10.1210/me.2015-1255
   Gustot T, 2006, HEPATOLOGY, V43, P989, DOI 10.1002/hep.21138
   Hamano M, 2014, J GASTROENTEROL, V49, P305, DOI 10.1007/s00535-013-0780-7
   Han J, 2013, NAT CELL BIOL, V15, P481, DOI 10.1038/ncb2738
   Hellerbrand C, 2010, DIGEST DIS, V28, P783, DOI 10.1159/000324286
   Hiramatsu N, 2014, MOL BIOL CELL, V25, P1411, DOI 10.1091/mbc.E13-11-0664
   Hritz I, 2008, HEPATOLOGY, V48, P1224, DOI 10.1002/hep.22470
   IMPERIALE TF, 1990, ANN INTERN MED, V113, P299, DOI 10.7326/0003-4819-113-4-299
   Ji C, 2003, GASTROENTEROLOGY, V124, P1488, DOI 10.1016/S0016-5085(03)00276-2
   Ji C, 2015, BIOMOLECULES, V5, P1099, DOI 10.3390/biom5021099
   Kang XQ, 2009, HEPATOLOGY, V50, P1241, DOI 10.1002/hep.23090
   Kiviluoto S, 2013, BBA-MOL CELL RES, V1833, P1612, DOI 10.1016/j.bbamcr.2013.01.026
   Kon K, 2017, HEPATOL RES, V47, pE44, DOI 10.1111/hepr.12720
   Kon K, 2010, AM J PHYSIOL-GASTR L, V299, pG329, DOI 10.1152/ajpgi.00361.2009
   Kusama H, 2017, J GASTROENTEROL, V52, P611, DOI 10.1007/s00535-016-1256-3
   Leung TM, 2013, J HEPATOL, V58, P395, DOI 10.1016/j.jhep.2012.08.018
   Mahli A, 2016, DIGEST DIS, V34, P32, DOI 10.1159/000447279
   Malhi H, 2011, J HEPATOL, V54, P795, DOI 10.1016/j.jhep.2010.11.005
   Malhotra JD, 2008, P NATL ACAD SCI USA, V105, P18525, DOI 10.1073/pnas.0809677105
   Mathurin P, 2011, GUT, V60, P255, DOI 10.1136/gut.2010.224097
   Morinaga M, 2015, J CLIN BIOCHEM NUTR, V57, P183, DOI 10.3164/jcbn.15-75
   Naveau S, 1997, HEPATOLOGY, V25, P108, DOI 10.1002/hep.510250120
   Okumura K, 2006, HEPATOL RES, V36, P217, DOI 10.1016/j.hepres.2006.07.009
   Petrasek J, 2012, J CLIN INVEST, V122, P3476, DOI 10.1172/JCI60777
   Raff EJ, 2015, J CLIN TRANSL HEPATO, V3, P9, DOI 10.14218/JCTH.2015.00001
   Rehm J, 2013, J HEPATOL, V59, P160, DOI 10.1016/j.jhep.2013.03.007
   Rolo AP, 2012, FREE RADICAL BIO MED, V52, P59, DOI 10.1016/j.freeradbiomed.2011.10.003
   Roy D, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0133012
   Roychowdhury S, 2009, HEPATOLOGY, V49, P1326, DOI 10.1002/hep.22776
   Sasaki M, 2015, J GASTROENTEROL, V50, P984, DOI 10.1007/s00535-014-1033-0
   Shen Z, 2010, AM J PHYSIOL-GASTR L, V298, pG364, DOI 10.1152/ajpgi.00456.2009
   Southwood XC, 2016, J NEUROSCI, V36, P6803, DOI 10.1523/JNEUROSCI.1118-15.2016
   Szuster-Ciesielska A, 2013, J GASTROENTEROL, V48, P222, DOI 10.1007/s00535-012-0619-7
   Takashima S, 2016, AM J PHYSIOL-GASTR L, V311, pG1105, DOI 10.1152/ajpgi.00465.2015
   Tan TCH, 2013, LAB INVEST, V93, P1295, DOI 10.1038/labinvest.2013.121
   Tilg H, 2010, HEPATOLOGY, V52, P1836, DOI 10.1002/hep.24001
   Tsukamoto H, 2007, J GASTROENTEROL, V42, P603, DOI 10.1007/s00535-007-2075-3
   Watanabe S, 2015, J GASTROENTEROL, V50, P364, DOI 10.1007/s00535-015-1050-7
   Watanabe S, 2015, HEPATOL RES, V45, P363, DOI 10.1111/hepr.12511
   Wu DF, 2012, FREE RADICAL BIO MED, V53, P1346, DOI 10.1016/j.freeradbiomed.2012.07.005
   Yamagata H, 2013, HEPATOL RES, V43, P276, DOI 10.1111/j.1872-034X.2012.01062.x
   Yamaguchi H, 2004, J BIOL CHEM, V279, P45495, DOI 10.1074/jbc.M406933200
   Yamashina S, 2005, ALCOHOL CLIN EXP RES, V29, p246S, DOI 10.1097/01.alc.0000191128.54871.40
   Yang LL, 2012, FREE RADICAL BIO MED, V53, P1170, DOI 10.1016/j.freeradbiomed.2012.06.029
   Yu CH, 2010, WORLD J GASTROENTERO, V16, P2435, DOI 10.3748/wjg.v16.i19.2435
   Zhou HP, 2014, FRONT GENET, V5, DOI 10.3389/fgene.2014.00112
NR 58
TC 9
Z9 10
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-6008
EI 1530-0277
J9 ALCOHOL CLIN EXP RES
JI Alcoholism (NY)
PD APR
PY 2019
VL 43
IS 4
BP 617
EP 627
DI 10.1111/acer.13982
PG 11
WC Substance Abuse
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Substance Abuse
GA HR2AV
UT WOS:000462938800007
PM 30748014
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Chen, JH
   Tan, LW
   Long, Z
   Wang, LF
   Hu, L
   Yang, D
AF Chen, Jinhong
   Tan, Liwen
   Long, Zhou
   Wang, Lifeng
   Hu, Li
   Yang, Dong
TI Drug-naive patients with schizophrenia have metabolic disorders that are
   not associated with polymorphisms in the LEP (-2548G/A) and 5-HTR2C
   (-759C/T) genes
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
LA English
DT Article
DE Schizophrenia; metabolic syndrome; antipsychotic drugs; leptin; 5-HTR2C
ID 5-HT2C RECEPTOR GENE; GLUCOSE-TOLERANCE; EXCESS MORTALITY; PROMOTER
   REGION; 1ST EPISODE; WEIGHT-GAIN; OBESITY; HTR2C; RISK; ANTIPSYCHOTICS
AB Schizophrenia is a mental disorder that is primarily caused by polygenic mutations. Schizophrenic patients are more likely to suffer from metabolic syndrome (MS), which is usually accompanied by polymorphisms in the leptin (LEP) gene at the -2548 (G/A) locus and the 5-hydroxytryptamine receptor 2C (5-HTR2C) gene at the -759 (C/T) locus. Hence, we hypothesized an association between these polymorphisms and schizophrenia incidence. A total of 148 drug-naive schizophrenic patients and 165 normal controls were enrolled in the study. Blood glucose levels, lipid levels, and other metabolic markers were measured. MALDI-TOFMS was performed to analyse genotypes of LEP and 5-HTR2C at -2548 (G/A) and -759 (C/T) loci, respectively. Patients with first-episode schizophrenia showed higher levels of fasting blood glucose and the 2-h postprandial glucose (2 hPG), as well as higher insulin resistance indices, but showed lower high-density lipoprotein cholesterol (HDL-C) levels compared to those of the controls. The above results were partly observed when the analysis was performed separately in males and females. Schizophrenic and healthy participants showed no significant differences in the genotypes and allele frequencies in the leptin and 5-HTR2C genes. Patients with varying genotypes of -2548 (G/A) in the leptin gene and -759 (C/T) in the 5-HTR2C gene showed no differences in the indices related to the glucose and lipid metabolism. Taken together, drug-naive schizophrenia patients showed some incidence of metabolic disorders, but polymorphisms in the LEP (-2548G/A) and 5-HTR2C (-759C/T) genes were not associated with schizophrenia or metabolic disorders.
C1 [Chen, Jinhong; Hu, Li; Yang, Dong] Brain Hosp Hunan Prov, Dept Sleeping Disorders & Neurosis, Changsha, Hunan, Peoples R China.
   [Long, Zhou; Wang, Lifeng] Cent S Univ, Dept Clin Psychol, Xiangya Hosp 3, Changsha, Hunan, Peoples R China.
   [Tan, Liwen] Cent S Univ, Dept Clin Psychol, Xiangya Hosp 2, Changsha 410008, Hunan, Peoples R China.
C3 Central South University; Central South University
RP Tan, LW (corresponding author), Cent S Univ, Dept Clin Psychol, Xiangya Hosp 2, Changsha 410008, Hunan, Peoples R China.
EM tanliwen211@163.com
FU National Natural Science Foundation of China on Evaluation and Related
   Mechanism of Metabolic Syndrome in Schizophrenic Patients and their
   First-degree Relatives [30971051]
FX This study was funded by the National Natural Science Foundation of
   China on Evaluation and Related Mechanism of Metabolic Syndrome in
   Schizophrenic Patients and their First-degree Relatives (NO. 30971051).
CR Ananth J, 2004, CURR PHARM DESIGN, V10, P2219, DOI 10.2174/1381612043384088
   Bhuvaneswar CG, 2009, CNS DRUGS, V23, P1003, DOI 10.2165/11530020-000000000-00000
   Bizzini A, 2010, CLIN MICROBIOL INFEC, V16, P1614, DOI 10.1111/j.1469-0691.2010.03311.x
   Brown S, 2000, BRIT J PSYCHIAT, V177, P212, DOI 10.1192/bjp.177.3.212
   Brown S, 1997, BRIT J PSYCHIAT, V171, P502, DOI 10.1192/bjp.171.6.502
   Callicott JH, 2005, P NATL ACAD SCI USA, V102, P8627, DOI 10.1073/pnas.0500515102
   Cohn T, 2004, CAN J PSYCHIAT, V49, P753, DOI 10.1177/070674370404901106
   COOPER GR, 1992, JAMA-J AM MED ASSOC, V267, P1652, DOI 10.1001/jama.267.12.1652
   Dizaji BF, 2018, DIABETES METAB SYND, V12, P783, DOI 10.1016/j.dsx.2018.04.009
   Ellingrod VL, 2005, AM J MED GENET B, V134B, P76, DOI 10.1002/ajmg.b.20169
   Ferreira-Julio MA, 2014, J NUTRIGENET NUTRIGE, V7, P225, DOI 10.1159/000371767
   Gregoor JG, 2010, PSYCHIAT GENET, V20, P311, DOI 10.1097/YPG.0b013e32833b6378
   Gunes A, 2009, J CLIN PSYCHOPHARM, V29, P65, DOI 10.1097/JCP.0b013e31819302c3
   Haffner SM, 1997, DIABETES CARE, V20, P1087, DOI 10.2337/diacare.20.7.1087
   Hakko H, 2006, SCHIZOPHR RES, V84, P15, DOI 10.1016/j.schres.2006.03.020
   Heiskanen T, 2003, J CLIN PSYCHIAT, V64, P575, DOI 10.4088/JCP.v64n0513
   Hoffstedt J, 2002, HORM METAB RES, V34, P355, DOI 10.1055/s-2002-33466
   Kang SH, 2011, PSYCHIAT INVEST, V8, P262, DOI 10.4306/pi.2011.8.3.262
   Karoutzou G, 2008, MOL PSYCHIATR, V13, P245, DOI 10.1038/sj.mp.4002096
   Kim EH, 2012, NEUROSURGERY, V70, P1106, DOI 10.1227/NEU.0b013e31823f5c16
   Koch C, 2010, J NEUROSCI, V30, P16180, DOI 10.1523/JNEUROSCI.3202-10.2010
   Krishnamurthy D, 2013, WORLD J BIOL PSYCHIA, V14, P478, DOI 10.3109/15622975.2011.601759
   Lee NY, 2011, PROG NEURO-PSYCHOPH, V35, P1273, DOI 10.1016/j.pnpbp.2011.03.022
   Moravcíková N, 2013, ACTA BIOCHIM POL, V60, P807
   Mulder H, 2007, PHARMACOGENOMICS J, V7, P318, DOI 10.1038/sj.tpj.6500422
   Mulder H, 2007, J CLIN PSYCHOPHARM, V27, P338, DOI 10.1097/JCP.0b013e3180a76dc0
   Nagai T, 2009, PSYCHOPHARMACOLOGY, V202, P315, DOI 10.1007/s00213-008-1240-6
   Pooley EC, 2004, AM J MED GENET B, V126B, P124, DOI 10.1002/ajmg.b.20143
   RedaRoshdy, 2011, MIDDLE EAST CURR PSY, V18, P109, DOI DOI 10.1097/01.XME.0000395562.63321.35
   Risselada AJ, 2012, PHARMACOGENOMICS J, V12, P62, DOI 10.1038/tpj.2010.66
   Ryan MCM, 2003, AM J PSYCHIAT, V160, P284, DOI 10.1176/appi.ajp.160.2.284
   Saddichha S, 2008, SCHIZOPHR RES, V101, P266, DOI 10.1016/j.schres.2008.01.004
   Sahin DS, 2013, CELL BIOCHEM BIOPHYS, V65, P243, DOI 10.1007/s12013-012-9427-1
   Shabana Hasnain S, 2016, J BIOSCIENCE, V41, P1
   Shah NR, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033308
   Sliwa JK, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/1471-244X-14-52
   Spelman LM, 2003, SCHIZOPHR RES, V60, P51, DOI 10.1016/S0920-9964(03)80536-4
   [孙静 Sun Jing], 2005, [中国行为医学科学, Chinese Journal of Behavioral Medical Science], V14, P905
   Thakore JH, 2004, BRIT J PSYCHIAT, V184, pS76, DOI 10.1192/bjp.184.47.s76
   Theisen FM, 2004, PSYCHIAT GENET, V14, P139, DOI 10.1097/00041444-200409000-00003
   Trakovicka A., 2016, Acta Fytotechnica et Zootechnica, V19, P75, DOI 10.15414/afz.2016.19.si.75-79
   Yevtushenko OO, 2008, BRIT J PSYCHIAT, V192, P424, DOI 10.1192/bjp.bp.107.041723
   Yiannakouris Nikos, 2003, Hormones (Athens), V2, P229
   Yuan X, 2000, DIABETOLOGIA, V43, P373, DOI 10.1007/s001250050056
   Zhang Zhi-jun, 2003, Zhonghua Yi Xue Za Zhi, V83, P2119
   Zhang ZJ, 2004, BRIT J PSYCHIAT, V184, P58, DOI 10.1192/bjp.184.1.58
NR 46
TC 1
Z9 1
U1 1
U2 4
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1936-2625
J9 INT J CLIN EXP PATHO
JI Int. J. Clin. Exp. Pathol.
PY 2018
VL 11
IS 12
BP 5969
EP 5980
PG 12
WC Oncology; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Pathology
GA HG0LJ
UT WOS:000454636600045
PM 31949685
DA 2025-06-11
ER

PT J
AU Zhou, TH
   Pu, CC
   Huang, ZT
   Gao, TQ
   Zhou, EP
   Zheng, Y
   Zhang, D
   Huang, BJ
   Cheng, Z
   Shi, C
   Yu, X
AF Zhou, Tianhang
   Pu, Chengcheng
   Huang, Zetao
   Gao, Tianqi
   Zhou, Enpeng
   Zheng, Yue
   Zhang, Dan
   Huang, Bingjie
   Cheng, Zhang
   Shi, Chuan
   Yu, Xin
TI Weight changes following treatment with aripiprazole, risperidone and
   olanzapine: A 12-month study of first-episode schizophrenia patients in
   China
SO ASIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Schizophrenia; Weight gain; Antipsychotic; Metabolic Syndrome; China
ID SYNDROME SCALE PANSS; NONPHARMACOLOGICAL INTERVENTIONS;
   CARDIOVASCULAR-DISEASE; PSYCHOTIC DISORDERS; METABOLIC SYNDROME;
   CLINICAL-TRIAL; GAIN; RISK; ASSOCIATION; MORTALITY
AB Objectives: This study aimed to assess weight changes following antipsychotic treatment in first-episode schizo-phrenia (FES) patients and make a comparison of aripiprazole, risperidone and olanzapine. Predictors for long-term clinically relevant weight gain (CRW, >= 7%) were examined.Methods: We carried out a second analysis of data from the Chinese First-Episode Schizophrenia Trial. Repeated measures general linear model (GLM) statistics were used to compare body weight at each follow-up point (month of 1, 2, 3, 6, 9and 12). Logistic regression models were constructed to evaluate possible predictors for CRW. Results: Body weight increased with an average rate of 0.93 % per month, with the fastest growth rate occurring in first 3 months. CRW was observed in 79 % of patients. Participants from olanzapine group showed signifi-cantly higher weight gain than risperidone group and aripiprozole group. Repeated measures GLM revealed a significant main effect of time (p < 0.001) and asignificant time*group interaction was revealed (p < 0.001), while the between-subject group effect was not statistically significant (p = 0.272). Multivariate logistic regressionmodel showed that with smaller baseline BMI (OR = 1.33, p < 0.001), with a family history of mental disorder (OR = 5.08, p = 0.004), receiving olanzapine (OR = 2.35, p = 0.001), and CRW at first-month (OR = 4.29, p = 0.032) were independent predictors for first-year CRW.Conclusion: Antipsychotics are associated with a clinically significant weight gain in FES patients, which occurs mostly in first 3 months. Aripiprazole might not be an ideal choice in terms of long-term metabolic side-effects. Early and close metabolic monitoring should accompany antipsychotic prescription.
C1 [Zhou, Tianhang; Pu, Chengcheng; Huang, Zetao; Gao, Tianqi; Zhou, Enpeng; Zheng, Yue; Zhang, Dan; Huang, Bingjie; Cheng, Zhang; Shi, Chuan; Yu, Xin] Peking Univ, Peking Univ Hosp 6, Inst Mental Hlth, Natl Clin Res Ctr Mental Disorders,Clin Res Ctr,NH, Beijing, Peoples R China.
   [Yu, Xin] 51 Huayuanbeilu, Beijing 100191, Peoples R China.
C3 Peking University
RP Yu, X (corresponding author), 51 Huayuanbeilu, Beijing 100191, Peoples R China.
EM yuxin@bjmu.edu.cn
RI ZHou, Tianhang/HNQ-8900-2023
OI pu, chengcheng/0000-0002-1117-9531
CR Agarwal SM, 2022, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD013337.pub2
   Alvarez-Jiménez M, 2008, CNS DRUGS, V22, P547, DOI 10.2165/00023210-200822070-00002
   Bak M, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0244944
   Barton BB, 2020, EXPERT OPIN DRUG SAF, V19, P295, DOI 10.1080/14740338.2020.1713091
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   Cuerda C, 2011, CLIN NUTR, V30, P616, DOI 10.1016/j.clnu.2011.03.007
   Emsley R, 2003, SCHIZOPHR RES, V61, P47, DOI 10.1016/S0920-9964(02)00302-X
   First M.B., 2016, Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version
   Gaughran F, 2013, EVID-BASED MENT HEAL, V16, P18, DOI 10.1136/eb-2012-101072
   Grajales D, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8111336
   Han X, 2014, East Asian Arch Psychiatry, V24, P169
   Hjorthoj C, 2017, LANCET PSYCHIAT, V4, P295, DOI 10.1016/S2215-0366(17)30078-0
   Huhn M, 2019, LANCET, V394, P939, DOI [10.1016/S0140-6736(19)31135-3, 10.1176/appi.focus.18306]
   Jenny-Avital ER, 2002, NEW ENGL J MED, V347, P1888
   KAY SR, 1987, SCHIZOPHRENIA BULL, V13, P261, DOI 10.1093/schbul/13.2.261
   Kishimoto T, 2012, CURR OPIN PSYCHIATR, V25, P415, DOI 10.1097/YCO.0b013e328355e1ac
   Lane JM, 2017, NAT GENET, V49, P274, DOI 10.1038/ng.3749
   LINGJAERDE O, 1987, ACTA PSYCHIAT SCAND, V76, P7
   Lipkovich I, 2009, PSYCHOPHARMACOL BULL, V42, P23
   Maher AR, 2011, JAMA-J AM MED ASSOC, V306, P1359, DOI 10.1001/jama.2011.1360
   Malan-Müller S, 2016, SCHIZOPHR RES, V170, P1, DOI 10.1016/j.schres.2015.11.011
   Manu P, 2015, ACTA PSYCHIAT SCAND, V132, P97, DOI 10.1111/acps.12445
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Mustafa S, 2019, J CLIN PSYCHIAT, V80, DOI 10.4088/JCP.18m12717
   Mustafa S, 2018, SCHIZOPHR RES, V201, P287, DOI 10.1016/j.schres.2018.04.027
   Padmanabhan J.L., 2016, J PSYCHIATR RES
   Patsalos O, 2021, J PERS MED, V11, DOI 10.3390/jpm11030176
   Perez-Iglesias R, 2008, SCHIZOPHR RES, V99, P13, DOI 10.1016/j.schres.2007.10.022
   Perry BI, 2016, LANCET PSYCHIAT, V3, P1049, DOI 10.1016/S2215-0366(16)30262-0
   Pillinger T, 2020, LANCET PSYCHIAT, V7, P64, DOI 10.1016/S2215-0366(19)30416-X
   Pillinger T, 2017, JAMA PSYCHIAT, V74, P261, DOI 10.1001/jamapsychiatry.2016.3803
   Rekhi G, 2016, GEN HOSP PSYCHIAT, V43, P46, DOI 10.1016/j.genhosppsych.2016.09.005
   Saha S, 2007, ARCH GEN PSYCHIAT, V64, P1123, DOI 10.1001/archpsyc.64.10.1123
   Schoemakers RJ, 2019, J CHILD ADOL PSYCHOP, V29, P192, DOI 10.1089/cap.2018.0111
   Shu L., 2007, CHINA GUIDELINES PRE
   Si TM, 2011, PSYCHIAT RES, V185, P275, DOI 10.1016/j.psychres.2010.05.001
   Skolnik NS, 2014, J FAM PRACTICE, V63, pS3
   Suetani S., 2021, SCHIZOPHR RES
   Tek C, 2016, EARLY INTERV PSYCHIA, V10, P193, DOI 10.1111/eip.12251
   Vancampfort D, 2019, WORLD PSYCHIATRY, V18, P53, DOI 10.1002/wps.20614
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vázquez-Bourgon J, 2018, PSYCHOPHARMACOLOGY, V235, P245, DOI 10.1007/s00213-017-4763-x
   Walker ER, 2015, JAMA PSYCHIAT, V72, P334, DOI 10.1001/jamapsychiatry.2014.2502
   Westman J, 2018, EPIDEMIOL PSYCH SCI, V27, P519, DOI 10.1017/S2045796017000166
   Weston-Green K, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033548
   Zhang QS, 2014, INT J NEUROPSYCHOPH, V17, P807, DOI 10.1017/S1461145713001697
NR 46
TC 4
Z9 4
U1 0
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1876-2018
EI 1876-2026
J9 ASIAN J PSYCHIATR
JI Asian J. Psychiatr.
PD JUN
PY 2023
VL 84
AR 103594
DI 10.1016/j.ajp.2023.103594
EA APR 2023
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA F7MR9
UT WOS:000984153400001
PM 37094459
DA 2025-06-11
ER

PT J
AU Rajagopalan, G
   Chandrasekaran, SP
   Venkatraman, AC
AF Rajagopalan, Geetha
   Chandrasekaran, Sathiya Priya
   Venkatraman, Anuradha Carani
TI Troxerutin attenuates diet-induced oxidative stress, impairment of
   mitochondrial biogenesis and respiratory chain complexes in mice heart
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article
DE high fat high fructose diet; metabolic syndrome; mitochondrial
   biogenesis; mitochondrial dynamics; oxidative stress; troxerutin
ID CELL-DEATH; DYSFUNCTION; CLONING; HUMANS; REGION; MOUSE; GENE; UCP3
AB Mitochondrial abnormality is thought to play a key role in cardiac disease originating from the metabolic syndrome (MS). We evaluated the effect of troxerutin (TX), a semi-synthetic derivative of the natural bioflavanoid rutin, on the respiratory chain complex activity, oxidative stress, mitochondrial biogenesis and dynamics in heart of high fat, high fructose diet (HFFD) -induced mouse model of MS. Adult male Mus musculus mice of body weight 25-30g were fed either control diet or HFFD for 60days. Mice from each dietary regimen were divided into two groups on the 16th day and were treated or untreated with TX (150mg/kg body weight [bw], per oral) for the next 45days. At the end of experimental period, respiratory chain complex activity, uncoupling proteins (UCP)-2 and -3, mtDNA content, mitochondrial biogenesis and dynamics, oxidative stress markers and reactive oxygen species (ROS) generation were analyzed. Reduced mtDNA abundance with alterations in the expression of genes related to mitochondrial biogenesis and fission and fusion processes were observed in HFFD-fed mice. Disorganized and smaller mitochondria, reduction in complexes I, III and IV activities (by about 55%) and protein levels of UCP-2 (52%) and UCP-3 (46%) were noted in these mice. TX administration suppressed oxidative stress, improved the oxidative capacity and biogenesis and restored fission/fusion imbalance in the cardiac mitochondria of HFFD-fed mice. TX protects the myocardium by modulating the putative molecules of mitochondrial biogenesis and dynamics and by its anti-oxidant function in a mouse model of MS.
C1 [Rajagopalan, Geetha; Chandrasekaran, Sathiya Priya; Venkatraman, Anuradha Carani] Annamalai Univ, Dept Biochem & Biotechnol, Chidambaram, Tamil Nadu, India.
C3 Annamalai University
RP Venkatraman, AC (corresponding author), Annamalai Univ, Dept Biochem & Biotechnol, Chidambaram, Tamil Nadu, India.
EM cvaradha@yahoo.com
RI Venkatraman, Anuradha/U-8717-2019; Chandrasekaran, Sathiya
   Priya/H-3718-2018
OI Carani Venkatraman, Anuradha/0000-0001-9924-2533; Chandrasekaran,
   Sathiya Priya/0000-0002-1943-1244
FU Indian Council of Medical Research
FX Indian Council of Medical Research
CR Acín A, 1999, BIOCHEM BIOPH RES CO, V258, P278, DOI 10.1006/bbrc.1999.0530
   Arsenijevic D, 2000, NAT GENET, V26, P435, DOI 10.1038/82565
   Badalzadeh R, 2015, INT J ENDOCRINOL MET, V13, DOI 10.5812/ijem.25969
   Barzegar A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026012
   Bonnard C, 2008, J CLIN INVEST, V118, P789, DOI 10.1172/JCI32601
   Brand MD, 2005, CELL METAB, V2, P85, DOI 10.1016/j.cmet.2005.06.002
   Chung J, 2013, J AM COLL CARDIOL, V61, pE597, DOI 10.1016/S0735-1097(13)60597-5
   Deng JY, 2007, AM J PHYSIOL-HEART C, V293, pH978, DOI 10.1152/ajpheart.01002.2006
   Devi SL, 2010, AMINO ACIDS, V38, P869, DOI 10.1007/s00726-009-0293-0
   Dong F, 2007, DIABETES, V56, P2201, DOI 10.2337/db06-1596
   Fan SH, 2009, INT IMMUNOPHARMACOL, V9, P91, DOI 10.1016/j.intimp.2008.10.008
   Fonseca Vivian A, 2005, Clin Cornerstone, V7, P61, DOI 10.1016/S1098-3597(05)80069-9
   Geetha R, 2014, INT RES J PHARM, V5, P798
   Geetha R, 2015, MOL CELL BIOCHEM, V407, P263, DOI 10.1007/s11010-015-2474-3
   Geetha R, 2014, MOL CELL BIOCHEM, V387, P123, DOI 10.1007/s11010-013-1877-2
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   Lionetti L, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0092753
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Maurya DK, 2004, J RADIAT RES, V45, P221, DOI 10.1269/jrr.45.221
   Medikayala S, 2011, AM J PHYSIOL-CELL PH, V300, pC338, DOI 10.1152/ajpcell.00248.2010
   Morino K, 2005, J CLIN INVEST, V115, P3587, DOI 10.1172/JCI25151
   Panchal SK, 2011, J CARDIOVASC PHARM, V57, P51, DOI [10.1097/FJC.0b013e3181feb90a, 10.1097/FJC.0b013e31821b1379]
   Patti ME, 2003, P NATL ACAD SCI USA, V100, P8466, DOI 10.1073/pnas.1032913100
   Puigserver P, 1998, CELL, V92, P829, DOI 10.1016/S0092-8674(00)81410-5
   Siri-Tarino PW, 2010, AM J CLIN NUTR, V91, P502, DOI 10.3945/ajcn.2008.26285
   SLATER EC, 1952, BIOCHEM J, V52, P185, DOI 10.1042/bj0520185
   Su KY, 2014, INT J MED SCI, V11, P528, DOI 10.7150/ijms.8220
   Teshima Y, 2003, CIRC RES, V93, P192, DOI 10.1161/01.RES.0000085581.60197.4D
   Topal AE, 2014, ENDOCR METAB IMMUNE, V14, P313, DOI 10.2174/1871530314666141028144702
   Tu NX, 1999, BIOCHEM BIOPH RES CO, V265, P326, DOI 10.1006/bbrc.1999.1663
   UYSAL M, 1989, J APPL TOXICOL, V9, P155, DOI 10.1002/jat.2550090304
   Vanithadevi B., 2008, INT J DIABETES METAB, V16, P35, DOI DOI 10.1159/000497651
   Vincent AM, 2004, DIABETES, V53, P726, DOI 10.2337/diabetes.53.3.726
   Wallace DC, 1999, SCIENCE, V283, P1482, DOI 10.1126/science.283.5407.1482
   Young ME, 2001, FASEB J, V15, P833, DOI 10.1096/fj.00-0351com
   Yu TZ, 2008, CARDIOVASC RES, V79, P341, DOI 10.1093/cvr/cvn104
   Yuzefovych LV, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054059
NR 38
TC 21
Z9 21
U1 2
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD JAN
PY 2017
VL 44
IS 1
BP 103
EP 113
DI 10.1111/1440-1681.12671
PG 11
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA EI4YD
UT WOS:000392499000012
PM 27626906
DA 2025-06-11
ER

PT J
AU Dreher, ML
AF Dreher, Mark L.
TI Whole Fruits and Fruit Fiber Emerging Health Effects
SO NUTRIENTS
LA English
DT Review
DE prebiotic effects; gastrointestinal health; weight management;
   cardiovascular disease; diabetes; metabolic syndrome; successful aging;
   cancer; psychological well-being; depression; asthma; bone mineral
   density
ID INFLAMMATORY-BOWEL-DISEASE; DOSE-RESPONSE METAANALYSIS; INTAKE REDUCES
   RISK; CHAIN FATTY-ACID; TYPE-2 DIABETES-MELLITUS; DIETARY ENERGY
   DENSITY; IN-VITRO FERMENTATION; BONE-MINERAL DENSITY; VEGETABLE
   CONSUMPTION; BLOOD-PRESSURE
AB Less than 10% of most Western populations consume adequate levels of whole fruits and dietary fiber with typical intake being about half of the recommended levels. Evidence of the beneficial health effects of consuming adequate levels of whole fruits has been steadily growing, especially regarding their bioactive fiber prebiotic effects and role in improved weight control, wellness and healthy aging. The primary aim of this narrative review article is to examine the increasing number of health benefits which are associated with the adequate intake of whole fruits, especially fruit fiber, throughout the human lifecycle. These potential health benefits include: protecting colonic gastrointestinal health (e.g., constipation, irritable bowel syndrome, inflammatory bowel diseases, and diverticular disease); promoting long-term weight management; reducing risk of cardiovascular disease, type 2 diabetes and metabolic syndrome; defending against colorectal and lung cancers; improving odds of successful aging; reducing the severity of asthma and chronic obstructive pulmonary disease; enhancing psychological well-being and lowering the risk of depression; contributing to higher bone mineral density in children and adults; reducing risk of seborrheic dermatitis; and helping to attenuate autism spectrum disorder severity. Low whole fruit intake represents a potentially more serious global population health threat than previously recognized, especially in light of the emerging research on whole fruit and fruit fiber health benefits.
C1 [Dreher, Mark L.] Nutr Sci Solut LLC, Wimberley, TX 78676 USA.
RP Dreher, ML (corresponding author), Nutr Sci Solut LLC, Wimberley, TX 78676 USA.
EM mdreher@nutriscisolutions.com
FU Hass Avocado Board
FX Funding was provided by the Hass Avocado Board, which had no input as to
   the content of this manuscript.
CR Abdullah MMH, 2015, FRONT PHARMACOL, V6, DOI 10.3389/fphar.2015.00167
   Adeloye D, 2015, J GLOB HEALTH, V5, P186, DOI 10.7189/jogh.05.020415
   Agostoni C, 2010, EFSA J, V8, DOI 10.2903/j.efsa.2010.1462
   Aguirre M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0113864
   Aldoori W, 2002, CAN FAM PHYSICIAN, V48, P1632
   AlEssa HB, 2016, J NUTR, V146, P306, DOI 10.3945/jn.115.219915
   AlEssa HB, 2015, AM J CLIN NUTR, V102, P1543, DOI 10.3945/ajcn.115.116558
   Aljadani HM, 2013, J OBES, V2013, DOI 10.1155/2013/525161
   Aljuraiban GS, 2015, BRIT J NUTR, V114, P1480, DOI 10.1017/S0007114515003098
   Alvarez-Acosta T, 2009, J AM COLL NUTR, V28, P169, DOI 10.1080/07315724.2009.10719768
   Amre DK, 2007, AM J GASTROENTEROL, V102, P2016, DOI 10.1111/j.1572-0241.2007.01411.x
   Ananthakrishnan AN, 2013, GASTROENTEROLOGY, V145, P970, DOI 10.1053/j.gastro.2013.07.050
   Andersen V, 2018, J CROHNS COLITIS, V12, P129, DOI 10.1093/ecco-jcc/jjx136
   Anderson JW, 2014, POSTGRAD MED, V126, P37, DOI 10.3810/pgm.2014.01.2723
   [Anonymous], DIET GUID AM 2015 20
   [Anonymous], DIET REF INT EN CARB
   [Anonymous], 2011, Continuous Update Project Report
   Appel LJ, 1997, NEW ENGL J MED, V336, P1117, DOI 10.1056/NEJM199704173361601
   Appiah D, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-16901-5
   ASCHERIO A, 1991, INT J EPIDEMIOL, V20, P886, DOI 10.1093/ije/20.4.886
   Ascherio A, 1996, HYPERTENSION, V27, P1065, DOI 10.1161/01.HYP.27.5.1065
   ASCHERIO A, 1992, CIRCULATION, V86, P1475, DOI 10.1161/01.CIR.86.5.1475
   Assmann KE, 2015, J NUTR, V145, P2139, DOI 10.3945/jn.115.210740
   Attaluri A, 2011, ALIMENT PHARM THER, V33, P822, DOI 10.1111/j.1365-2036.2011.04594.x
   Auerbach BJ, 2018, PREV MED, V109, P8, DOI 10.1016/j.ypmed.2018.01.004
   Aune D, 2017, INT J EPIDEMIOL, V46, P1029, DOI 10.1093/ije/dyw319
   Aune D, 2011, GASTROENTEROLOGY, V141, P106, DOI 10.1053/j.gastro.2011.04.013
   Baer DJ, 1997, J NUTR, V127, P579, DOI 10.1093/jn/127.4.579
   Bajerska J, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-29495-3
   Baker RA, 1997, J FOOD SCI, V62, P225, DOI 10.1111/j.1365-2621.1997.tb03973.x
   Bakolis I, 2018, CLIN EXP ALLERGY, V48, P1474, DOI 10.1111/cea.13243
   Bang SJ, 2018, AMB EXPRESS, V8, DOI 10.1186/s13568-018-0629-9
   Barbara G, 2017, GUT, V66, P1252, DOI 10.1136/gutjnl-2016-312377
   Barros R, 2008, ALLERGY, V63, P917, DOI 10.1111/j.1398-9995.2008.01665.x
   BARRY JL, 1995, BRIT J NUTR, V74, P303, DOI 10.1079/BJN19950137
   Basu A, 2012, J AGR FOOD CHEM, V60, P5687, DOI 10.1021/jf203488k
   Behrens G, 2018, DTSCH ARZTEBL INT, V115, P578, DOI 10.3238/arztebl.2018.0578
   Behzadi P., 2015, SOJ Immunol, V3, P1, DOI 10.15226/soji/3/2/00125
   Ben QW, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000001599
   Ben QW, 2014, GASTROENTEROLOGY, V146, P689, DOI 10.1053/j.gastro.2013.11.003
   Berding K, 2018, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00515
   Berding K, 2018, J NUTR BIOCHEM, V56, P165, DOI 10.1016/j.jnutbio.2018.01.002
   Berger C, 2008, CAN MED ASSOC J, V178, P1660, DOI 10.1503/cmaj.071416
   Berthon BS, 2013, RESPIROLOGY, V18, P447, DOI 10.1111/resp.12015
   Bertoia ML, 2015, PLOS MED, V12, DOI 10.1371/journal.pmed.1001878
   BEYER PL, 1978, J AM DIET ASSOC, V72, P271
   Bianchi F, 2018, APPL MICROBIOL BIOT, V102, P8827, DOI 10.1007/s00253-018-9234-8
   Boland BB, 2017, MOL METAB, V6, P958, DOI 10.1016/j.molmet.2017.04.010
   Bolduc FV, 2016, EBIOMEDICINE, V8, P331, DOI 10.1016/j.ebiom.2016.04.025
   BOLTON RP, 1981, AM J CLIN NUTR, V34, P211, DOI 10.1093/ajcn/34.2.211
   Bondonno NP, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030159
   Borgi L, 2016, HYPERTENSION, V67, P288, DOI 10.1161/HYPERTENSIONAHA.115.06497
   Bradbury KE, 2014, AM J CLIN NUTR, V100, p394S, DOI 10.3945/ajcn.113.071357
   Breneman CB, 2013, BRIT J NUTR, V110, P375, DOI 10.1017/S0007114512004953
   Brigham EP, 2018, ANN AM THORAC SOC, V15, P675, DOI 10.1513/AnnalsATS.201707-571OC
   Brookie KL, 2018, FRONT PSYCHOL, V9, DOI 10.3389/fpsyg.2018.00487
   Brotherton CS, 2016, CLIN GASTROENTEROL H, V14, P1130, DOI 10.1016/j.cgh.2015.12.029
   Brouns F, 2012, EUR J CLIN NUTR, V66, P591, DOI 10.1038/ejcn.2011.208
   Brown L, 1999, AM J CLIN NUTR, V69, P30
   Brunstrom JM, 2018, APPETITE, V120, P589, DOI 10.1016/j.appet.2017.10.015
   Buil-Cosiales P, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030295
   Buil-Cosiales P, 2014, AM J CLIN NUTR, V100, P1498, DOI 10.3945/ajcn.114.093757
   Burton-Freeman BM, 2018, FOOD FUNCT, V9, P1009, DOI [10.1039/c7fo01650f, 10.1039/C7FO01650F]
   Byrd-Bredbenner C, 2017, J FOOD SCI, V82, P1523, DOI 10.1111/1750-3841.13754
   Byrne CS, 2016, AM J CLIN NUTR, V104, P5, DOI 10.3945/ajcn.115.126706
   Cândido FG, 2015, NUTR HOSP, V31, P299, DOI 10.3305/nh.2015.31.1.7578
   Carabotti Marilia, 2018, Drugs Context, V7, P212526, DOI 10.7573/dic.212526
   Carraro JCC, 2016, J NUTRIGENET NUTRIGE, V9, P95, DOI 10.1159/000448101
   Cavallo DN, 2016, J ACAD NUTR DIET, V116, P1387, DOI 10.1016/j.jand.2016.03.019
   CDC National Center for Chronic Disease Prevention and Health Promotion, RES PRACT SER, V1
   Cepeda AM, 2017, LUNG, V195, P683, DOI 10.1007/s00408-017-0044-z
   Champagne CM, 2011, J AM DIET ASSOC, V111, P1826, DOI 10.1016/j.jada.2011.09.014
   Chan AOO, 2007, WORLD J GASTROENTERO, V13, P4771, DOI 10.3748/wjg.v13.i35.4771
   Chang CC, 2010, ASIA PAC J CLIN NUTR, V19, P451
   Chen CYO, 2017, NUTRIENTS, V9, DOI 10.3390/nu9020130
   Chen JP, 2018, NUTRIENTS, V10, DOI 10.3390/nu10010024
   Chen JZ, 2018, CLIN COLORECTAL CANC, V17, pE541, DOI 10.1016/j.clcc.2018.05.001
   Christensen AS, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-29
   Chung WSF, 2017, FEMS MICROBIOL ECOL, V93, DOI 10.1093/femsec/fix127
   Chung WSF, 2016, BMC BIOL, V14, DOI 10.1186/s12915-015-0224-3
   Condezo-Hoyos L, 2014, FOOD CHEM, V161, P208, DOI 10.1016/j.foodchem.2014.03.122
   Conner TS, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0171206
   Conner TS, 2017, FRONT PSYCHOL, V8, DOI 10.3389/fpsyg.2017.00119
   Conner TS, 2015, BRIT J HEALTH PSYCH, V20, P413, DOI 10.1111/bjhp.12113
   Cozma-Petrut A, 2017, WORLD J GASTROENTERO, V23, P3771, DOI 10.3748/wjg.v23.i21.3771
   Crowe FL, 2014, GUT, V63, P1450, DOI 10.1136/gutjnl-2013-304644
   Crowe Francesca L, 2011, BMJ, V343, pd4131, DOI 10.1136/bmj.d4131
   Cuello-Garcia C, 2017, CLIN EXP ALLERGY, V47, P1468, DOI 10.1111/cea.13042
   Dahl C, 2018, NUTRIENTS, V10, DOI 10.3390/nu10020137
   Dahl WJ, 2015, J ACAD NUTR DIET, V115, P1861, DOI 10.1016/j.jand.2015.09.003
   Dai ZL, 2018, J BONE MINER RES, V33, P241, DOI 10.1002/jbmr.3308
   Davis HC, 2018, IRISH J MED SCI, V187, P393, DOI 10.1007/s11845-017-1686-9
   de Carvalho CM, 2017, AM J CLIN NUTR, V106, P1238, DOI 10.3945/ajcn.117.157263
   De Filippis Francesca, 2016, Gut, V65, P1812, DOI 10.1136/gutjnl-2015-309957
   de Oliveira MC, 2008, APPETITE, V51, P291, DOI 10.1016/j.appet.2008.03.001
   de Vries J, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030130
   Deehan EC, 2016, TRENDS ENDOCRIN MET, V27, P239, DOI 10.1016/j.tem.2016.03.001
   den Biggelaar LJCJ, 2019, EUR J NUTR, V58, P597, DOI 10.1007/s00394-018-1644-y
   Dong HL, 2016, APPETITE, V107, P478, DOI 10.1016/j.appet.2016.08.118
   Dreher ML., 2018, DIETARY FIBER HLTH D, P67
   Du HD, 2017, PLOS MED, V14, DOI 10.1371/journal.pmed.1002279
   Eid N, 2015, BRIT J NUTR, V114, P1226, DOI 10.1017/S0007114515002780
   El-Salhy M, 2017, INT J MOL MED, V40, P607, DOI 10.3892/ijmm.2017.3072
   Emery E A, 1997, Nutr Clin Pract, V12, P72, DOI 10.1177/011542659701200272
   Esfahani A, 2014, J NUTR SCI, V3, DOI 10.1017/jns.2013.33
   Esmaillzadeh A, 2006, AM J CLIN NUTR, V84, P1489, DOI 10.1093/ajcn/84.6.1489
   Fabiani R, 2016, PUBLIC HEALTH NUTR, V19, P2603, DOI 10.1017/S136898001600032X
   Farajian P, 2010, EAT BEHAV, V11, P201, DOI 10.1016/j.eatbeh.2010.02.004
   Fellet M., 2017, ACS CHEM LIFE, V1, P1
   Ferdowsian HR, 2010, AM J HEALTH PROMOT, V24, P384, DOI 10.4278/ajhp.081027-QUAN-255
   Fernández-Navarro T, 2017, NUTRIENTS, V9, DOI 10.3390/nu9060551
   Fernando NNT, 2018, NUTRIENTS, V10, DOI 10.3390/nu10020178
   Flood-Obbagy JE, 2009, APPETITE, V52, P416, DOI 10.1016/j.appet.2008.12.001
   Fogelholm M, 2012, FOOD NUTR RES, V56, DOI 10.3402/fnr.v56i0.19103
   Folkerts J, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01067
   Forootan M, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000010631
   Fulgoni VL, 2017, FOOD NUTR RES, V61, DOI 10.1080/16546628.2017.1378567
   Fulgoni VL, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-1
   Montalvo IAG, 2018, NUTR HOSP, V35, P582, DOI 10.20960/nh.1504
   García-Calzón S, 2014, INT J OBESITY, V38, P177, DOI 10.1038/ijo.2013.68
   García-Calzón S, 2015, AM J CLIN NUTR, V102, P897, DOI 10.3945/ajcn.115.116863
   Garcia-Larsen V, 2016, ALLERGY, V71, P433, DOI 10.1111/all.12800
   Garcia-Mantrana I, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.00890
   Gianfredi V, 2018, INT J FOOD SCI NUTR, V69, P904, DOI 10.1080/09637486.2018.1446917
   Gopinath B, 2016, J GERONTOL A-BIOL, V71, P1335, DOI 10.1093/gerona/glw091
   Gopinath B, 2016, J GERONTOL A-BIOL, V71, P349, DOI 10.1093/gerona/glv189
   Goyal MS, 2018, ANNU REV NUTR, V38, P381, DOI 10.1146/annurev-nutr-082117-051652
   Grimaldi R, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0523-3
   Grimaldi R, 2017, FEMS MICROBIOL ECOL, V93, DOI 10.1093/femsec/fiw233
   Grooms KN, 2013, AM J MED, V126, P1059, DOI 10.1016/j.amjmed.2013.07.023
   HABER GB, 1977, LANCET, V2, P679
   Haddad E, 2018, EAT BEHAV, V31, P35, DOI 10.1016/j.eatbeh.2018.08.001
   Hairston KG, 2012, OBESITY, V20, P421, DOI 10.1038/oby.2011.171
   Hanson C, 2016, ANN AM THORAC SOC, V13, P643, DOI 10.1513/AnnalsATS.201509-609OC
   Hartley L, 2016, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD011472.pub2
   Hartley Louise, 2013, Cochrane Database Syst Rev, pCD009874, DOI 10.1002/14651858.CD009874.pub2
   Haskey N, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030259
   Hjorth MF, 2018, INT J OBESITY, V42, P284, DOI [10.1038/ijo.2017.220, 10.1038/ijo.2018.1]
   Hjorth MF, 2019, INT J OBESITY, V43, P149, DOI 10.1038/s41366-018-0093-2
   Hodge AM, 2014, J NUTR HEALTH AGING, V18, P221, DOI 10.1007/s12603-013-0405-0
   Hooshmand S, 2016, OSTEOPOROSIS INT, V27, P2271, DOI 10.1007/s00198-016-3524-8
   Hooshmand S, 2011, BRIT J NUTR, V106, P923, DOI 10.1017/S000711451100119X
   Hosseini B, 2018, AM J CLIN NUTR, V108, P136, DOI 10.1093/ajcn/nqy082
   Hosseini B, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040341
   Hosseinpour-Niazi S, 2015, J HUM NUTR DIET, V28, P236, DOI 10.1111/jhn.12242
   Hou JK, 2011, AM J GASTROENTEROL, V106, P563, DOI 10.1038/ajg.2011.44
   Hu D, 2014, STROKE, V45, P1613, DOI 10.1161/STROKEAHA.114.004836
   Huang HH, 2016, SCI REP-UK, V6, DOI 10.1038/srep23625
   Ibrahim M, 2018, DIABETES-METAB RES, V34, DOI 10.1002/dmrr.3021
   Iván J, 2017, STEM CELLS DEV, V26, P1724, DOI 10.1089/scd.2017.0035
   James LJ, 2015, APPETITE, V95, P132, DOI 10.1016/j.appet.2015.07.005
   JENKINS DJA, 1985, P SOC EXP BIOL MED, V180, P422, DOI 10.3181/00379727-180-42199
   Jew S, 2009, J MED FOOD, V12, P925, DOI 10.1089/jmf.2008.0268
   John JH, 2002, LANCET, V359, P1969, DOI 10.1016/S0140-6736(02)98858-6
   Juonala M, 2010, EUR HEART J, V31, P1745, DOI 10.1093/eurheartj/ehq141
   Kaiser KA, 2014, AM J CLIN NUTR, V100, P567, DOI 10.3945/ajcn.114.090548
   Kaluza J, 2018, INT J EPIDEMIOL, V47, P1897, DOI 10.1093/ije/dyy178
   Kaluza J, 2018, EPIDEMIOLOGY, V29, P254, DOI 10.1097/EDE.0000000000000750
   Kaluza J, 2017, THORAX, V72, P500, DOI 10.1136/thoraxjnl-2015-207851
   Kant AK, 2005, INT J OBESITY, V29, P950, DOI 10.1038/sj.ijo.0802980
   Kashtanova DA, 2016, NUTRITION, V32, P620, DOI 10.1016/j.nut.2015.12.037
   Keenan MJ, 2015, AGE, V37, DOI 10.1007/s11357-015-9817-6
   KELSAY JL, 1978, AM J CLIN NUTR, V31, P1149, DOI 10.1093/ajcn/31.7.1149
   Khan K, 2018, NUTR METAB CARDIOVAS, V28, P3, DOI 10.1016/j.numecd.2017.09.007
   Kim J, 2018, J ACAD NUTR DIET, V118, P1438, DOI 10.1016/j.jand.2017.08.122
   Kim S, 2015, NUTR CANCER, V67, P580, DOI 10.1080/01635581.2015.1011787
   Kim YK, 2018, CURR NEUROPHARMACOL, V16, P559, DOI 10.2174/1570159X15666170915141036
   Kingsbury M, 2016, J EPIDEMIOL COMMUN H, V70, P155, DOI 10.1136/jech-2015-205858
   Klinder A, 2016, FOOD FUNCT, V7, P1788, DOI [10.1039/C5FO01096A, 10.1039/c5fo01096a]
   Klurfeld DM, 2018, AM J PHYSIOL-ENDOC M, V315, pE1087, DOI 10.1152/ajpendo.00058.2018
   Koutsos A, 2017, NUTRIENTS, V9, DOI 10.3390/nu9060533
   Krishnan S, 2018, AM J CLIN NUTR, V108, P266, DOI 10.1093/ajcn/nqy113
   Kunzmann AT, 2016, INT J CANCER, V138, P1851, DOI 10.1002/ijc.29922
   Kushi LH, 2012, CA-CANCER J CLIN, V62, P30, DOI 10.3322/caac.20140
   Lai HTM, 2015, EUR J EPIDEMIOL, V30, P1035, DOI 10.1007/s10654-015-0050-5
   Lai JS, 2014, AM J CLIN NUTR, V99, P181, DOI 10.3945/ajcn.113.069880
   Langkilde AM, 2002, AM J CLIN NUTR, V75, P104, DOI 10.1093/ajcn/75.1.104
   Larsen N, 2018, FOOD MICROBIOL, V74, P11, DOI 10.1016/j.fm.2018.02.015
   Laserna-Mendieta EJ, 2018, J CROHNS COLITIS, V12, P204, DOI 10.1093/ecco-jcc/jjx137
   Lee Yuan Kun, 2012, Microbial Ecology in Health and Disease, V23, P15, DOI 10.3402/mehd.v23i0.18572
   Lever E, 2014, ALIMENT PHARM THER, V40, P750, DOI 10.1111/apt.12913
   Lever E, 2019, CLIN NUTR, V38, P165, DOI 10.1016/j.clnu.2018.01.003
   Li BR, 2016, J CLIN HYPERTENS, V18, P468, DOI 10.1111/jch.12777
   Li F, 2015, EUR J GASTROEN HEPAT, V27, P623, DOI 10.1097/MEG.0000000000000330
   Li JJ, 2013, PUBLIC HEALTH NUTR, V16, P78, DOI 10.1017/S1368980012001127
   Li SS, 2015, ENDOCRINE, V48, P454, DOI 10.1007/s12020-014-0351-6
   Li Z., 2018, NUTRITION
   Lie L, 2018, NUTRIENTS, V10, DOI 10.3390/nu10050628
   Lindström J, 2006, DIABETOLOGIA, V49, P912, DOI 10.1007/s00125-006-0198-3
   Liu SM, 2003, AM J CLIN NUTR, V78, P920, DOI 10.1093/ajcn/78.5.920
   Liu XQ, 2015, NUTR RES, V35, P753, DOI 10.1016/j.nutres.2015.05.021
   Looman M, 2018, BRIT J NUTR, V120, P435, DOI 10.1017/S0007114518001277
   Low DY, 2015, FOOD FUNCT, V6, P2464, DOI [10.1039/c5fo00363f, 10.1039/C5FO00363F]
   Lucas S, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-017-02490-4
   Luis AS, 2018, NAT MICROBIOL, V3, P210, DOI 10.1038/s41564-017-0079-1
   Ma J, 2016, EUR RESPIR J, V47, P122, DOI 10.1183/13993003.00591-2015
   Ma YS, 2015, ANN INTERN MED, V162, P248, DOI 10.7326/M14-0611
   Mahmassani HA, 2018, AM J CLIN NUTR, V107, P523, DOI 10.1093/ajcn/nqx078
   Mahmood MW, 2019, EUR J NUTR, V58, P2393, DOI 10.1007/s00394-018-1792-0
   Maljaars PWJ, 2008, PHYSIOL BEHAV, V95, P271, DOI 10.1016/j.physbeh.2008.07.018
   Mandalari G, 2016, FOOD FUNCT, V7, P4048, DOI [10.1039/C6FO01137C, 10.1039/c6fo01137c]
   Marlett JA, 1997, J AM DIET ASSOC, V97, P1139, DOI 10.1016/S0002-8223(97)00275-7
   McCall DO, 2009, CIRCULATION, V119, P2153, DOI 10.1161/CIRCULATIONAHA.108.831297
   McGartland CP, 2004, AM J CLIN NUTR, V80, P1019, DOI 10.1093/ajcn/80.4.1019
   McRorie Johnson W Jr, 2015, Nutr Today, V50, P82
   McRorie Johnson W Jr, 2015, Nutr Today, V50, P90
   Meegan AP, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030238
   Mellendick K, 2018, NUTRIENTS, V10, DOI 10.3390/nu10020136
   Mendes AP, 2011, J ASTHMA, V48, P235, DOI 10.3109/02770903.2011.555039
   Mendis S, 2011, Global Atlas on Cardiovascular Disease Prevention and Control
   Miki T, 2016, NUTRITION, V32, P584, DOI 10.1016/j.nut.2015.11.014
   MILES CW, 1988, J NUTR, V118, P1075, DOI 10.1093/jn/118.9.1075
   MILES CW, 1992, J NUTR, V122, P306, DOI 10.1093/jn/122.2.306
   Miller V, 2017, LANCET, V390, P2037, DOI [10.1016/S0140-6736(17)32253-5, 10.1016/s0140-6736(17)32253-5]
   Milte CM, 2016, EUR J NUTR, V55, P423, DOI 10.1007/s00394-015-1123-7
   Mitsou EK, 2011, ANAEROBE, V17, P384, DOI 10.1016/j.anaerobe.2011.03.018
   Miyamoto J, 2016, CURR OPIN NEPHROL HY, V25, P379, DOI 10.1097/MNH.0000000000000246
   Morimoto N, 2018, BRIT J NUTR, V119, P620, DOI 10.1017/S0007114517003725
   Mujcic R, 2016, AM J PUBLIC HEALTH, V106, P1504, DOI 10.2105/AJPH.2016.303260
   Muraki I, 2013, BMJ-BRIT MED J, V347, DOI 10.1136/bmj.f5001
   Mursu J, 2014, AM J CLIN NUTR, V99, P328, DOI 10.3945/ajcn.113.069641
   Myint PK, 2007, PUBLIC HEALTH NUTR, V10, P34, DOI 10.1017/S1368980007222608
   Mytton OT, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-886
   Nagarajan N, 2015, EUR J GASTROEN HEPAT, V27, P1002, DOI 10.1097/MEG.0000000000000425
   Najjar RS, 2018, CLIN CARDIOL, V41, P307, DOI 10.1002/clc.22863
   National Alliance for Recovery Residences, 2018, 30 NARR
   Nguyen B, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2016-014201corr1
   Nicodemus-Johnson J, 2017, NUTRIENTS, V9, DOI 10.3390/nu9070752
   Nomura SJO, 2018, NUTR CANCER, V70, P904, DOI 10.1080/01635581.2018.1491608
   Nuñez-Cordoba JM, 2009, EUR J CLIN NUTR, V63, P605, DOI 10.1038/ejcn.2008.22
   O'Keefe SJD, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms7342
   O'Keeffe LM, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2018-021611
   Oddy WH, 2009, PREV MED, V49, P39, DOI 10.1016/j.ypmed.2009.05.009
   Othman F, 2018, BMC WOMENS HEALTH, V18, DOI 10.1186/s12905-018-0594-0
   Padayachee A, 2017, CRIT REV FOOD SCI, V57, P59, DOI 10.1080/10408398.2013.850652
   Pal S, 2011, BRIT J NUTR, V105, P90, DOI 10.1017/S0007114510003132
   Paniagua C, 2014, ANN BOT-LONDON, V114, P1375, DOI 10.1093/aob/mcu149
   Park E, 2018, NUTRIENTS, V10, DOI 10.3390/nu10091287
   Pascal M, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01584
   Patel BP, 2013, J FOOD SCI, V78, pA5, DOI 10.1111/1750-3841.12070
   Pearson-Stuttard J, 2017, PLOS MED, V14, DOI 10.1371/journal.pmed.1002311
   Peou S, 2016, J CLIN LIPIDOL, V10, P161, DOI 10.1016/j.jacl.2015.10.011
   Pluznick JL, 2014, GUT MICROBES, V5, P202, DOI 10.4161/gmic.27492
   Post RE, 2012, J AM BOARD FAM MED, V25, P16, DOI 10.3122/jabfm.2012.01.110148
   Pozuelo M, 2015, SCI REP-UK, V5, DOI 10.1038/srep12693
   Prynne CJ, 2006, AM J CLIN NUTR, V83, P1420, DOI 10.1093/ajcn/83.6.1420
   Qiu R, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0168906
   Rabbani GH, 2001, GASTROENTEROLOGY, V121, P554, DOI 10.1053/gast.2001.27178
   Rabbani GH, 2009, PEDIATR INFECT DIS J, V28, P420, DOI 10.1097/INF.0b013e31819510b5
   Rautiainen S, 2015, J NUTR, V145, P960, DOI 10.3945/jn.114.199158
   Ravn-Haren G, 2013, EUR J NUTR, V52, P1875, DOI 10.1007/s00394-012-0489-z
   Raynor HA, 2011, EAT BEHAV, V12, P119, DOI 10.1016/j.eatbeh.2011.01.008
   Renzaho AMN, 2011, HEALTH PROMOT INT, V26, P263, DOI 10.1093/heapro/daq054
   Riviere A, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.00979
   Rogers PJ, 2018, NUTRIENTS, V10, DOI 10.3390/nu10040431
   Rolls BJ, 2017, NUTR BULL, V42, P246, DOI 10.1111/nbu.12280
   Romaguera D, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011588
   Root MM, 2012, NUTRIENTS, V4, P29, DOI 10.3390/nu4010029
   Rush EC, 2002, ASIA PAC J CLIN NUTR, V11, P164, DOI 10.1046/j.1440-6047.2002.00287.x
   Saavedra MJ, 2018, ARCH ARGENT PEDIATR, V116, pE684, DOI [10.5546/aap.2018.eng.e684, 10.5546/aap.2018.e684]
   Saghafian F, 2018, EUR J NUTR, V57, P2295, DOI 10.1007/s00394-018-1652-y
   Saghafian F, 2018, BRIT J NUTR, V119, P1087, DOI 10.1017/S0007114518000697
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Salem AE, 2018, ARAB J GASTROENTEROL, V19, P136, DOI 10.1016/j.ajg.2018.02.008
   Salvi S, 2014, CLIN CHEST MED, V35, P17, DOI 10.1016/j.ccm.2013.09.011
   Samuel BS, 2008, P NATL ACAD SCI USA, V105, P16767, DOI 10.1073/pnas.0808567105
   Sanctuary MR, 2018, FRONT NUTR, V5, DOI 10.3389/fnut.2018.00040
   Sanders MGH, 2019, J INVEST DERMATOL, V139, P108, DOI 10.1016/j.jid.2018.07.027
   Sansbury LB, 2009, AM J EPIDEMIOL, V170, P576, DOI 10.1093/aje/kwp169
   Sardá FAH, 2016, J FUNCT FOODS, V24, P63, DOI 10.1016/j.jff.2016.04.001
   Sargeant LA, 2001, EUR J CLIN NUTR, V55, P342, DOI 10.1038/sj.ejcn.1601162
   Schmier JK, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-374
   Schulze MB, 2007, ARCH INTERN MED, V167, P956, DOI 10.1001/archinte.167.9.956
   Schwingshackl L, 2018, INT J CANCER, V142, P1748, DOI 10.1002/ijc.31198
   Schwingshackl L, 2017, ADV NUTR, V8, P793, DOI 10.3945/an.117.017178
   Schwingshackl L, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0140846
   Sekgala MD, 2018, NUTRIENTS, V10, DOI 10.3390/nu10040504
   Seyedrezazadeh E, 2014, NUTR REV, V72, P411, DOI 10.1111/nure.12121
   Sharma SP, 2016, NUTRIENTS, V8, DOI 10.3390/nu8100633
   Sharp WG, 2018, J ACAD NUTR DIET, V118, P1943, DOI 10.1016/j.jand.2018.05.005
   Shinohara K, 2010, ANAEROBE, V16, P510, DOI 10.1016/j.anaerobe.2010.03.005
   Siervo M, 2015, BRIT J NUTR, V113, P1, DOI 10.1017/S0007114514003341
   Silva FM, 2013, NUTR REV, V71, P790, DOI 10.1111/nure.12076
   Simpson HL, 2015, ALIMENT PHARM THER, V42, P158, DOI 10.1111/apt.13248
   Slavin J, 2013, NUTRIENTS, V5, P1417, DOI 10.3390/nu5041417
   Slavin JL, 2012, ADV NUTR, V3, P506, DOI 10.3945/an.112.002154
   Song MY, 2018, JAMA ONCOL, V4, P71, DOI 10.1001/jamaoncol.2017.3684
   Spiller RC, 2015, NEUROGASTROENT MOTIL, V27, P305, DOI 10.1111/nmo.12526
   Statovci D, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.00838
   Steinemann N, 2018, RESPIRATION, V95, P454, DOI 10.1159/000488148
   Stephen AM, 2017, NUTR RES REV, V30, P149, DOI 10.1017/S095442241700004X
   Steptoe A, 2017, PSYCHONEUROENDOCRINO, V86, P122, DOI 10.1016/j.psyneuen.2017.09.016
   Streppel MT, 2005, ARCH INTERN MED, V165, P150, DOI 10.1001/archinte.165.2.150
   Stull AJ, 2010, J NUTR, V140, P1764, DOI 10.3945/jn.110.125336
   Sun BQ, 2018, NUTRIENTS, V10, DOI 10.3390/nu10081091
   Sylvetsky AC, 2017, J NUTR, V147, P2060, DOI 10.3945/jn.117.252395
   Tabernero M, 2011, J AGR FOOD CHEM, V59, P8968, DOI 10.1021/jf201777w
   Tabeshpour J, 2017, PHYTOTHER RES, V31, P819, DOI 10.1002/ptr.5805
   Tanaka S, 2013, EPIDEMIOLOGY, V24, P204, DOI 10.1097/EDE.0b013e318281725e
   Tap J, 2015, ENVIRON MICROBIOL, V17, P4954, DOI 10.1111/1462-2920.13006
   Taylor AM, 2020, NUTR NEUROSCI, V23, P237, DOI 10.1080/1028415X.2018.1493808
   Theuwissen E, 2008, PHYSIOL BEHAV, V94, P285, DOI 10.1016/j.physbeh.2008.01.001
   Threapleton DE, 2013, BMJ-BRIT MED J, V347, DOI 10.1136/bmj.f6879
   Tian XC, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0173054
   Tian Y, 2018, PUBLIC HEALTH NUTR, V21, P756, DOI 10.1017/S136898001700310X
   TINKER LF, 1991, AM J CLIN NUTR, V53, P1259, DOI 10.1093/ajcn/53.5.1259
   Tiwary CM, 1997, J AM COLL NUTR, V16, P423, DOI 10.1080/07315724.1997.10718708
   Törrönen R, 2013, J NUTR, V143, P430, DOI 10.3945/jn.112.169771
   Tucker LA, 2018, NUTRIENTS, V10, DOI 10.3390/nu10040400
   Tucker LA, 2009, J NUTR, V139, P576, DOI 10.3945/jn.108.096685
   Tuohy KM, 2012, J AGR FOOD CHEM, V60, P8776, DOI 10.1021/jf2053959
   US HHS, 2015, SCI REPORT, P1
   Venancio VP, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201701034
   Vendrame S, 2016, ANTIOXIDANTS-BASEL, V5, DOI 10.3390/antiox5040034
   Vernarelli JA, 2018, EUR J NUTR, V57, P351, DOI 10.1007/s00394-016-1324-8
   Veronese N, 2018, AM J CLIN NUTR, V107, P436, DOI 10.1093/ajcn/nqx082
   Vieira AR, 2016, ANN ONCOL, V27, P81, DOI 10.1093/annonc/mdv381
   Vogtmann E, 2013, CANCER CAUSE CONTROL, V24, P1935, DOI 10.1007/s10552-013-0268-z
   Vong MH, 2013, BENEF MICROBES, V4, P291, DOI 10.3920/BM2013.0006
   Vulcan A, 2015, BRIT J NUTR, V114, P959, DOI 10.1017/S0007114515002743
   Wanders AJ, 2014, INT J OBESITY, V38, P794, DOI 10.1038/ijo.2013.176
   Wanders AJ, 2011, OBES REV, V12, P724, DOI 10.1111/j.1467-789X.2011.00895.x
   Wang F, 2015, J MICROBIOL BIOTECHN, V25, P1195, DOI 10.4014/jmb.1410.10014
   Wang L, 2015, J AM HEART ASSOC, V4, DOI 10.1161/JAHA.114.001355
   Wang L, 2012, AM J HYPERTENS, V25, P180, DOI 10.1038/ajh.2011.186
   Wang M, 2015, EUR J CLIN NUTR, V69, P1184, DOI 10.1038/ejcn.2015.64
   Wang PY, 2016, J DIABETES INVEST, V7, P56, DOI 10.1111/jdi.12376
   Wang YP, 2015, LUNG CANCER, V88, P124, DOI 10.1016/j.lungcan.2015.02.015
   WEBB P, 1983, HUM NUTR-CLIN NUTR, V37, P117
   Wei BZ, 2018, CLIN NUTR, V37, P1935, DOI 10.1016/j.clnu.2017.10.019
   Weickert MO, 2018, J NUTR, V148, P7, DOI 10.1093/jn/nxx008
   Weisman A, 2018, CAN J CARDIOL, V34, P552, DOI 10.1016/j.cjca.2018.03.002
   Weitkunat K, 2017, AM J CLIN NUTR, V105, P1544, DOI 10.3945/ajcn.117.152702
   Whelton SP, 2005, J HYPERTENS, V23, P475, DOI 10.1097/01.hjh.0000160199.51158.cf
   Whisner CM, 2018, CALCIFIED TISSUE INT, V102, P443, DOI 10.1007/s00223-017-0339-3
   Wien M, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-155
   Willers SM, 2011, EUR RESPIR J, V37, P1060, DOI 10.1183/09031936.00106109
   Williams BA, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18102203
   Williamson DA, 2018, EXPERT REV ENDOCRINO, V13, P295, DOI 10.1080/17446651.2018.1535896
   WISKER E, 1990, J NUTR, V120, P1331, DOI 10.1093/jn/120.11.1331
   World Cancer Research Fund American Institute for Cancer Research, 2007, FOOD NUTR PHYS ACT P, P280
   Wu HY, 2003, AM J CLIN NUTR, V78, P1085, DOI 10.1093/ajcn/78.6.1085
   Wu L, 2016, J HUM HYPERTENS, V30, P573, DOI 10.1038/jhh.2016.44
   Xi P, 2016, MOL NUTR FOOD RES, V60, P1819, DOI 10.1002/mnfr.201500963
   Xu H, 2018, NUTRITION, V54, P48, DOI 10.1016/j.nut.2018.03.009
   Xu Lin, 2015, Zhonghua Wei Chang Wai Ke Za Zhi, V18, P267
   Xu Lin, 2014, Zhonghua Yi Xue Za Zhi, V94, P3813
   Yang T, 2015, HYPERTENSION, V65, P1331, DOI 10.1161/HYPERTENSIONAHA.115.05315
   Yao BD, 2014, EUR J EPIDEMIOL, V29, P79, DOI 10.1007/s10654-013-9876-x
   Yeo Rimkyo, 2017, Clin Nutr Res, V6, P172, DOI 10.7762/cnr.2017.6.3.172
   Young RP, 2016, AM J RESP CELL MOL, V54, P161, DOI 10.1165/rcmb.2015-0250PS
   Yu ZM, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2017-018060
   Yuan S, 2018, PUBLIC HEALTH, V157, P121, DOI 10.1016/j.puhe.2018.01.027
   Zhang Y, 2018, PUBLIC HEALTH NUTR, V21, P1693, DOI 10.1017/S1368980018000381
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
   Zhou MS, 2010, J HYPERTENS, V28, P527, DOI 10.1097/HJH.0b013e3283340da8
NR 356
TC 191
Z9 207
U1 10
U2 60
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2018
VL 10
IS 12
AR 1833
DI 10.3390/nu10121833
PG 54
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA HG6EG
UT WOS:000455073200014
PM 30487459
OA gold, Green Published, Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Akoumianakis, I
   Antoniades, C
AF Akoumianakis, Ioannis
   Antoniades, Charalambos
TI Impaired Vascular Redox Signaling in the Vascular Complications of
   Obesity and Diabetes Mellitus
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
DE vascular disease; vascular redox signaling; oxidative stress; obesity;
   insulin resistance
ID PROTEIN-KINASE-C; PERIVASCULAR ADIPOSE-TISSUE; GLYCATION-END-PRODUCTS;
   NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS; NADPH OXIDASE; ENDOTHELIAL
   DYSFUNCTION; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME
AB Significance: Oxidative stress, a crucial regulator of vascular disease pathogenesis, may be involved in the vascular complications of obesity, systemic insulin resistance (IR), and diabetes mellitus (DM). Recent Advances: Excessive production of reactive oxygen species in the vascular wall has been linked with vascular disease pathogenesis. Recent evidence has revealed that vascular redox state is dysregulated in cases of obesity, systemic IR, and DM, potentially participating in the well-known vascular complications of these disease entities. Critical Issues: The detrimental effects of obesity and the metabolic syndrome on vascular biology have been extensively described at a clinical level. Further, vascular oxidative stress has often been associated with the presence of obesity and IR as well as with a variety of detrimental vascular phenotypes. However, the mechanisms of vascular redox state regulation under conditions of obesity and systemic IR, as well as their clinical relevance, are not adequately explored. In addition, the notion of vascular IR, and its relationship with systemic parameters of obesity and systemic IR, is not fully understood. In this review, we present all the important components of vascular redox state and the evidence linking oxidative stress with obesity and IR. Future Directions: Future studies are required to describe the cellular effects and the translational potential of vascular redox state in the context of vascular disease. In addition, further elucidation of the direct vascular effects of obesity and IR is required for better management of the vascular complications of DM. Antioxid. Redox Signal. 00, 000-000.
C1 [Akoumianakis, Ioannis; Antoniades, Charalambos] Univ Oxford, Div Cardiovasc Med, Oxford, England.
C3 University of Oxford
RP Antoniades, C (corresponding author), Univ Oxford, John Radcliffe Hosp, Div Cardiovasc Med, CVM L6 West Wing,Headley Way, Oxford OX3 9DU, England.
EM antoniad@well.ox.ac.uk
RI Akoumianakis, Ioannis/ACD-9816-2022
OI Akoumianakis, Ioannis/0000-0002-4674-0210; Antoniades,
   Charalambos/0000-0002-6983-5423
FU British Heart Foundation [FS/16/15/32047, PG/13/56/30383]; National
   Institute for Health Research Oxford Biomedical Research Centre;
   European Commission (ITN network RADOX); NovoNordisk Foundation
   [NNF15CC0018486]; Alexandros S. Onassis Public Benefit Foundation
FX C.A. acknowledges support by the British Heart Foundation
   (FS/16/15/32047 and PG/13/56/30383), the National Institute for Health
   Research Oxford Biomedical Research Centre, the European Commission (ITN
   network RADOX), and the NovoNordisk Foundation (NNF15CC0018486). I.A.
   acknowledges support by the Alexandros S. Onassis Public Benefit
   Foundation.
CR Abdul-Ghani M, 2016, DIABETES CARE, V39, P717, DOI 10.2337/dc16-0041
   Adams TD, 2007, NEW ENGL J MED, V357, P753, DOI 10.1056/NEJMoa066603
   Akoumianakis I, 2017, BRIT J PHARMACOL, V174, P3411, DOI 10.1111/bph.13666
   Akoumianakis I, 2017, CARDIOVASC RES, V113, P999, DOI 10.1093/cvr/cvx111
   Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
   [Anonymous], ANTIOXID REDOX SIGNA
   Antoniades C, 2006, CIRCULATION, V114, P1193, DOI 10.1161/CIRCULATIONAHA.106.612325
   Antonopoulos AS, 2016, OBES REV, V17, P989, DOI 10.1111/obr.12440
   Antonopoulos AS, 2015, DIABETES, V64, P2207, DOI 10.2337/db14-1011
   Aoki M, 2001, HYPERTENSION, V38, P48, DOI 10.1161/01.HYP.38.1.48
   Badimon L, 2017, CARDIOVASC RES, V113, P1064, DOI 10.1093/cvr/cvx096
   Baggio LL, 2007, GASTROENTEROLOGY, V132, P2131, DOI 10.1053/j.gastro.2007.03.054
   Basuroy S, 2009, AM J PHYSIOL-CELL PH, V296, pC422, DOI 10.1152/ajpcell.00381.2008
   Beckman JA, 2016, CIRC RES, V118, P1771, DOI 10.1161/CIRCRESAHA.115.306884
   Bournat Juan C, 2010, Curr Opin Endocrinol Diabetes Obes, V17, P446, DOI 10.1097/MED.0b013e32833c3026
   Briasoulis A, 2009, CURR PHARM DESIGN, V15, P3078, DOI 10.2174/138161209789058057
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Brownlee M, 2005, DIABETES, V54, P1615, DOI 10.2337/diabetes.54.6.1615
   Buchwald H., 2004, JAMA (Journal of the American Medical Association), V292, P1724, DOI 10.1001/jama.292.14.1724
   Burke A, 2003, PROG CARDIOVASC DIS, V46, P79, DOI 10.1016/S0033-0620(03)00076-8
   Carillon J, 2013, PHARM RES-DORDR, V30, P2718, DOI 10.1007/s11095-013-1113-5
   Ceriello A, 2013, DIABETES CARE, V36, P2346, DOI 10.2337/dc12-2469
   Chatterjee TK, 2009, CIRC RES, V104, P541, DOI 10.1161/CIRCRESAHA.108.182998
   Chen JF, 2016, AM J TRANSL RES, V8, P2169
   Chilton R, 2015, DIABETES OBES METAB, V17, P1180, DOI 10.1111/dom.12572
   Choudhary BP, 2007, J AM COLL CARDIOL, V50, P1047, DOI 10.1016/j.jacc.2007.06.008
   Clarke RE, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030125
   Connelly KA, 2009, CIRC-HEART FAIL, V2, P129, DOI 10.1161/CIRCHEARTFAILURE.108.765750
   Corvo ML, 2015, PHARM RES-DORDR, V32, P91, DOI 10.1007/s11095-014-1447-7
   Dadu RT, 2014, NAT REV CARDIOL, V11, P563, DOI 10.1038/nrcardio.2014.84
   Dao VTV, 2015, ANTIOXID REDOX SIGN, V23, P1113, DOI 10.1089/ars.2015.6430
   Das Evcimen N, 2007, PHARMACOL RES, V55, P498, DOI 10.1016/j.phrs.2007.04.016
   Davis CA, 1998, J AM COLL CARDIOL, V31, P816, DOI 10.1016/S0735-1097(97)00561-5
   DELEON DD, 1993, GENEREVIEWSR
   Dey D, 2006, MOL CELL ENDOCRINOL, V246, P60, DOI 10.1016/j.mce.2005.12.014
   Dicker D, 2011, DIABETES CARE, V34, pS276, DOI 10.2337/dc11-s229
   Dikalov S, 2011, FREE RADICAL BIO MED, V51, P1289, DOI 10.1016/j.freeradbiomed.2011.06.033
   Ding ZF, 2015, CARDIOVASC RES, V107, P556, DOI 10.1093/cvr/cvv178
   Doughan AK, 2008, CIRC RES, V102, P488, DOI 10.1161/CIRCRESAHA.107.162800
   Drummond GR, 2011, NAT REV DRUG DISCOV, V10, P453, DOI 10.1038/nrd3403
   Escribano-Lopez I, 2016, REDOX BIOL, V10, P200, DOI 10.1016/j.redox.2016.10.017
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   Fadini GP, 2011, VASC PHARMACOL, V55, P10, DOI 10.1016/j.vph.2011.05.001
   Farese RV, 2014, EXPERT OPIN THER TAR, V18, P1163, DOI 10.1517/14728222.2014.944897
   Finkel T, 2000, NATURE, V408, P239, DOI 10.1038/35041687
   Fisslthaler B, 2003, NITRIC OXIDE-BIOL CH, V8, P253, DOI 10.1016/S1089-8603(03)00042-9
   Förstermann U, 2008, NAT CLIN PRACT CARD, V5, P338, DOI 10.1038/ncpcardio1211
   Förstermann U, 2017, CIRC RES, V120, P713, DOI 10.1161/CIRCRESAHA.116.309326
   Förstermann U, 2012, EUR HEART J, V33, P829, DOI 10.1093/eurheartj/ehr304
   Förstermann U, 2006, CIRCULATION, V113, P1708, DOI 10.1161/CIRCULATIONAHA.105.602532
   Frey RS, 2002, CIRC RES, V90, P1012, DOI 10.1161/01.RES.0000017631.28815.8E
   Fukai T, 2011, ANTIOXID REDOX SIGN, V15, P1583, DOI 10.1089/ars.2011.3999
   GALOUGAHI KK, 2015, EUR HEART J, V1582, P1582
   Gao L, 2009, CARDIOVASC RES, V82, P9, DOI 10.1093/cvr/cvp031
   Gardner DSL, 2012, DIABETES METAB SYNDR, V5, P101, DOI 10.2147/DMSO.S23353
   Garrido AM, 2009, MOL CELL ENDOCRINOL, V302, P148, DOI 10.1016/j.mce.2008.11.003
   Ghosh M, 2004, BRIT J PHARMACOL, V141, P562, DOI 10.1038/sj.bjp.0705557
   Gletsu-Miller N, 2009, OBESITY, V17, P439, DOI 10.1038/oby.2008.542
   Gloire G, 2006, BIOCHEM PHARMACOL, V72, P1493, DOI 10.1016/j.bcp.2006.04.011
   Goldin A, 2006, CIRCULATION, V114, P597, DOI 10.1161/CIRCULATIONAHA.106.621854
   Gollasch M, 2017, ANNU REV PHARMACOL, V57, P417, DOI 10.1146/annurev-pharmtox-010716-104542
   Gopalakrishna R, 2000, FREE RADICAL BIO MED, V28, P1349, DOI 10.1016/S0891-5849(00)00221-5
   Green JB, 2015, NEW ENGL J MED, V373, P232, DOI 10.1056/NEJMoa1501352
   Griendling KK, 2003, CIRCULATION, V108, P1912, DOI 10.1161/01.CIR.0000093660.86242.BB
   Gu P, 2013, REV ENDOCR METAB DIS, V14, P49, DOI 10.1007/s11154-012-9230-8
   Gutterman DD, 2002, CIRC RES, V90, P5, DOI 10.1161/res.90.1.5
   Guzik B, 2013, INT J CARDIOL, V168, P2389, DOI 10.1016/j.ijcard.2013.01.278
   Guzik TJ, 2004, ARTERIOSCL THROM VAS, V24, P1614, DOI 10.1161/01.ATV.0000139011.94634.9d
   Hamer M, 2012, J CLIN ENDOCR METAB, V97, P2482, DOI 10.1210/jc.2011-3475
   Han Y, 2015, AM J PHYSIOL-LUNG C, V309, pL1027, DOI 10.1152/ajplung.00167.2015
   Harcourt BE, 2013, NAT REV ENDOCRINOL, V9, P113, DOI 10.1038/nrendo.2012.236
   Hashimoto T, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.116.003208
   Hecht N, 2017, EUR J PHARM BIOPHARM, V115, P206, DOI 10.1016/j.ejpb.2017.03.001
   Henquin JC, 2009, DIABETOLOGIA, V52, P739, DOI 10.1007/s00125-009-1314-y
   Henquin JC, 2000, DIABETES, V49, P1751, DOI 10.2337/diabetes.49.11.1751
   Hotamisligil GS, 1996, SCIENCE, V271, P665, DOI 10.1126/science.271.5249.665
   HPS3 TIMI55-REVEAl Collaborative, 2017, NEW ENGL J MED, V377, P1217, DOI 10.1056/NEJMoa1706444
   Hsueh WA, 2003, AM J CARDIOL, V92, p10J, DOI 10.1016/S0002-9149(03)00611-8
   Ibrahim MM, 2010, OBES REV, V11, P11, DOI 10.1111/j.1467-789X.2009.00623.x
   Icli B, 2017, CARDIOVASC RES, V113, P1024, DOI 10.1093/cvr/cvx098
   Inagaki K, 2003, CIRCULATION, V108, P869, DOI 10.1161/01.CIR.0000081943.93653.73
   Ishibashi Y, 2011, HORM METAB RES, V43, P731, DOI 10.1055/s-0031-1284383
   Itani SI, 2000, DIABETES, V49, P1353, DOI 10.2337/diabetes.49.8.1353
   Jakus V, 2004, PHYSIOL RES, V53, P131, DOI 10.33549/physiolres.930430
   Janani C, 2015, DIABETES METAB SYND, V9, P46, DOI 10.1016/j.dsx.2014.09.015
   Jiang ZY, 1999, J CLIN INVEST, V104, P447, DOI 10.1172/JCI5971
   Jojima T, 2017, ATHEROSCLEROSIS, V261, P44, DOI 10.1016/j.atherosclerosis.2017.04.001
   Jones DP, 2010, DIABETES OBES METAB, V12, P116, DOI 10.1111/j.1463-1326.2010.01266.x
   Jones MK, 2004, BIOCHEM BIOPH RES CO, V318, P520, DOI 10.1016/j.bbrc.2004.04.055
   Kahn BB, 2000, J CLIN INVEST, V106, P473, DOI 10.1172/JCI10842
   Karbach S, 2014, CURR PHARM DESIGN, V20, P3579, DOI 10.2174/13816128113196660748
   KARIMI G, 1936, EUR HEART J, P1576
   Katakam PVG, 2005, AM J PHYSIOL-HEART C, V288, pH854, DOI 10.1152/ajpheart.00715.2004
   Katsarou A, 2017, NAT REV DIS PRIMERS, V3, DOI 10.1038/nrdp.2017.16
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kelly KJ, 2008, AM J PHYSIOL-RENAL, V294, pF1136, DOI 10.1152/ajprenal.00396.2007
   Kim F, 2008, ARTERIOSCL THROM VAS, V28, P1982, DOI 10.1161/ATVBAHA.108.169722
   Kim F, 2007, CIRC RES, V100, P1589, DOI 10.1161/CIRCRESAHA.106.142851
   Kimura Y, 2010, ANTIOXID REDOX SIGN, V12, P1, DOI 10.1089/ars.2008.2282
   King AB, 2000, DIABETES CARE, V23, P557, DOI 10.2337/diacare.23.4.557b
   Konior A, 2014, ANTIOXID REDOX SIGN, V20, P2794, DOI 10.1089/ars.2013.5607
   Konopatskaya O, 2003, DIABETIC MED, V20, P838, DOI 10.1046/j.1464-5491.2003.01039.x
   Lassègue B, 2012, CIRC RES, V110, P1364, DOI 10.1161/CIRCRESAHA.111.243972
   Lassègue B, 2010, ARTERIOSCL THROM VAS, V30, P653, DOI 10.1161/ATVBAHA.108.181610
   Laugesen E, 2015, DIABETIC MED, V32, P843, DOI 10.1111/dme.12700
   Lee BW, 2010, INT J MOL MED, V26, P813, DOI 10.3892/ijmm_00000529
   Lee HJ, 2014, AM J NEPHROL, V40, P56, DOI 10.1159/000363421
   Levelt E, 2016, J AM COLL CARDIOL, V68, P53, DOI 10.1016/j.jacc.2016.03.597
   Li HG, 2014, ATHEROSCLEROSIS, V237, P208, DOI 10.1016/j.atherosclerosis.2014.09.001
   Li HG, 2013, CURR OPIN PHARMACOL, V13, P161, DOI 10.1016/j.coph.2013.01.006
   Li HG, 2013, TRENDS PHARMACOL SCI, V34, P313, DOI 10.1016/j.tips.2013.03.007
   Li MY, 2010, ANTIOXID REDOX SIGN, V12, P641, DOI 10.1089/ars.2009.2854
   Lin RY, 2002, ATHEROSCLEROSIS, V163, P303, DOI 10.1016/S0021-9150(02)00008-4
   Lin YJ, 2015, BIOCHEM BIOPH RES CO, V460, P497, DOI 10.1016/j.bbrc.2015.03.017
   Lipska KJ, 2017, JAMA-J AM MED ASSOC, V317, P1017, DOI 10.1001/jama.2017.0029
   Liu LM, 2014, ANTIOXID REDOX SIGN, V21, P1571, DOI 10.1089/ars.2013.5519
   Lizcano JM, 2002, CURR BIOL, V12, pR236, DOI 10.1016/S0960-9822(02)00777-7
   Lowell BB, 2005, SCIENCE, V307, P384, DOI 10.1126/science.1104343
   MacDonald TM, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2014-005354
   Madamanchi NR, 2005, ARTERIOSCL THROM VAS, V25, P950, DOI 10.1161/01.ATV.0000161050.77646.68
   Mahadev K, 2004, MOL CELL BIOL, V24, P1844, DOI 10.1128/MCB.24.5.1844-1854.2004
   Mannucci E, 2015, DRUG HEALTHC PATIENT, V7, P113, DOI 10.2147/DHPS.S43300
   MARGARITIS M, 2017, SCI TRANSL MED, V9
   Margaritis M, 2017, EUR HEART J, V38, P3094, DOI 10.1093/eurheartj/ehx177
   Margaritis M, 2013, CIRCULATION, V127, P2209, DOI 10.1161/CIRCULATIONAHA.112.001133
   Maritim AC, 2003, J BIOCHEM MOL TOXIC, V17, P24, DOI 10.1002/jbt.10058
   Marso SP, 2016, NEW ENGL J MED, V375, P311, DOI 10.1056/NEJMoa1603827
   Matsuda M, 2013, OBES RES CLIN PRACT, V7, pE330, DOI 10.1016/j.orcp.2013.05.004
   McDonald TJ, 2013, ANN CLIN BIOCHEM, V50, P403, DOI 10.1177/0004563213483458
   Meijer RI, 2015, DIABETOLOGIA, V58, P1907, DOI 10.1007/s00125-015-3606-8
   Meijer RI, 2013, DIABETES, V62, P590, DOI 10.2337/db11-1603
   Meijer RI, 2011, CURR DIABETES REP, V11, P211, DOI 10.1007/s11892-011-0186-y
   Minami T, 2003, J BIOL CHEM, V278, P6976, DOI 10.1074/jbc.M208974200
   Mochly-Rosen D, 2012, NAT REV DRUG DISCOV, V11, P937, DOI 10.1038/nrd3871
   Montezano AC, 2015, CAN J CARDIOL, V31, P631, DOI 10.1016/j.cjca.2015.02.008
   Münzel T, 2010, EUR HEART J, V31, P2741, DOI 10.1093/eurheartj/ehq396
   Murri M, 2010, OBES SURG, V20, P363, DOI 10.1007/s11695-009-0021-6
   Muslin AJ, 2008, CLIN SCI, V115, P203, DOI 10.1042/CS20070430
   Napoli C, 2003, P NATL ACAD SCI USA, V100, P2112, DOI 10.1073/pnas.0336359100
   Naylor RN, 2011, J DIABETES INVEST, V2, P158, DOI 10.1111/j.2040-1124.2011.00106.x
   Nishida K, 2017, CARDIOVASC RES, V113, P389, DOI 10.1093/cvr/cvx012
   Nomura J, 2014, SCI REP-UK, V4, DOI 10.1038/srep04554
   Nordberg J, 2001, FREE RADICAL BIO MED, V31, P1287, DOI 10.1016/S0891-5849(01)00724-9
   Nosalski R, 2017, BRIT J PHARMACOL, V174, P3496, DOI 10.1111/bph.13705
   Oelze M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0112394
   Ohashi M, 2006, ARTERIOSCL THROM VAS, V26, P2331, DOI 10.1161/01.ATV.0000238347.77590.c9
   Osorio H, 2012, OXID MED CELL LONGEV, V2012, DOI 10.1155/2012/542042
   Ott C, 2014, REDOX BIOL, V2, P411, DOI 10.1016/j.redox.2013.12.016
   Panday Arvind, 2015, Cell Mol Immunol, V12, P5, DOI 10.1038/cmi.2014.89
   Feoli AMP, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/587083
   Paneni F, 2013, EUR HEART J, V34, P2436, DOI 10.1093/eurheartj/eht149
   Paneni F, 2012, CIRC RES, V111, P278, DOI 10.1161/CIRCRESAHA.112.266593
   Papaharalambus CA, 2007, TRENDS CARDIOVAS MED, V17, P48, DOI 10.1016/j.tcm.2006.11.005
   Park SY, 2014, J PATHOL, V232, P87, DOI 10.1002/path.4286
   Payne GA, 2009, AM J PHYSIOL-HEART C, V297, pH460, DOI 10.1152/ajpheart.00116.2009
   Peluso Ilaria, 2012, Endocrine Metabolic & Immune Disorders-Drug Targets, V12, P351
   Peyroux J, 2006, PATHOL BIOL, V54, P405, DOI 10.1016/j.patbio.2006.07.006
   Pfeffer MA, 2015, NEW ENGL J MED, V373, P2247, DOI 10.1056/NEJMoa1509225
   Pirillo A, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/152786
   Poirier P, 2006, CIRCULATION, V113, P898, DOI 10.1161/CIRCULATIONAHA.106.171016
   Polak M, 2007, ORPHANET J RARE DIS, V2, DOI 10.1186/1750-1172-2-12
   Polhemus DJ, 2015, CARDIOVASC THER, V33, P216, DOI 10.1111/1755-5922.12128
   Potenza MA, 2009, AM J PHYSIOL-ENDOC M, V297, pE568, DOI 10.1152/ajpendo.00297.2009
   Prasad K, 2017, CURR PHARM DESIGN, V23, P937, DOI 10.2174/1381612822666161006143032
   Ramachandran A, 2002, FREE RADICAL BIO MED, V33, P1465, DOI 10.1016/S0891-5849(02)01142-5
   Rao AD, 2008, DIABETES CARE, V31, P1672, DOI 10.2337/dc08-0167
   Rask-Madsen C, 2013, CELL METAB, V17, P20, DOI 10.1016/j.cmet.2012.11.012
   Redza-Dutordoir M, 2016, BBA-MOL CELL RES, V1863, P2977, DOI 10.1016/j.bbamcr.2016.09.012
   Rey FE, 2001, CIRC RES, V89, P408, DOI 10.1161/hh1701.096037
   Ridker PM, 2017, NEW ENGL J MED, V377, P1119, DOI 10.1056/NEJMoa1707914
   Rippe C, 2010, AGING CELL, V9, P304, DOI 10.1111/j.1474-9726.2010.00557.x
   Roberts CK, 2002, CIRCULATION, V106, P2530, DOI 10.1161/01.CIR.0000040584.91836.0D
   Rorsman P, 2013, ANNU REV PHYSIOL, V75, P155, DOI 10.1146/annurev-physiol-030212-183754
   Salim HM, 2017, VASC PHARMACOL, V96-98, P19, DOI 10.1016/j.vph.2017.03.003
   Samuel VT, 2016, J CLIN INVEST, V126, P12, DOI 10.1172/JCI77812
   San Martin A, 2007, FREE RADICAL BIO MED, V42, P1671, DOI 10.1016/j.freeradbiomed.2007.02.002
   Sangle GV, 2010, ENDOCRINOLOGY, V151, P4455, DOI 10.1210/en.2010-0323
   Sarzani R, 2008, J HYPERTENS, V26, P831, DOI 10.1097/HJH.0b013e3282f624a0
   Sattar N, 2016, DIABETOLOGIA, V59, P1333, DOI 10.1007/s00125-016-3956-x
   Sattar N, 2010, LANCET, V375, P735, DOI 10.1016/S0140-6736(09)61965-6
   Savini I, 2013, INT J MOL SCI, V14, P10497, DOI 10.3390/ijms140510497
   Schalkwijk CG, 2005, CLIN SCI, V109, P143, DOI 10.1042/CS20050025
   Schauer PR, 2014, NEW ENGL J MED, V370, P2002, DOI 10.1056/NEJMoa1401329
   Scheen AJ, 2013, NAT REV CARDIOL, V10, P73, DOI 10.1038/nrcardio.2012.183
   Schieber M, 2014, CURR BIOL, V24, pR453, DOI 10.1016/j.cub.2014.03.034
   Schramm A, 2012, VASC PHARMACOL, V56, P216, DOI 10.1016/j.vph.2012.02.012
   Scirica BM, 2013, NEW ENGL J MED, V369, P1317, DOI 10.1056/NEJMoa1307684
   Sedeek M, 2010, AM J PHYSIOL-RENAL, V299, pF1348, DOI 10.1152/ajprenal.00028.2010
   Shah AM, 2004, HEART, V90, P486, DOI 10.1136/hrt.2003.029389
   Sheetz MJ, 2011, RETINA-J RET VIT DIS, V31, P1053, DOI 10.1097/IAE.0b013e3181fe545f
   SHULMAN GI, 2000, J CLIN INVEST, V106, P171, DOI [DOI 10.1172/JCI10583, 10.1172/jci10583]
   Siti HN, 2015, VASC PHARMACOL, V71, P40, DOI 10.1016/j.vph.2015.03.005
   Smits P, 1997, DIABETOLOGIA, V40, pS160, DOI 10.1007/s001250051438
   Sobrevia L, 2009, CURR VASC PHARMACOL, V7, P467, DOI 10.2174/157016109789043919
   Spitaler MM, 2002, DIABETOLOGIA, V45, P476, DOI 10.1007/s00125-002-0782-0
   Stenström G, 2005, DIABETES, V54, pS68, DOI 10.2337/diabetes.54.suppl_2.S68
   Tahara A, 2013, EUR J PHARMACOL, V715, P246, DOI 10.1016/j.ejphar.2013.05.014
   Tang XQ, 2014, FRONT PHYSIOL, V5, DOI 10.3389/fphys.2014.00175
   Taygerly JP, 2013, BIOORGAN MED CHEM, V21, P979, DOI 10.1016/j.bmc.2012.11.058
   Teixeira G, 2017, BRIT J PHARMACOL, V174, P1647, DOI 10.1111/bph.13532
   Timsit Jose, 2005, Treat Endocrinol, V4, P9, DOI 10.2165/00024677-200504010-00002
   Torres-Leal FL, 2010, CELL BIOCHEM FUNCT, V28, P623, DOI 10.1002/cbf.1706
   Tousoulis D, 2011, CURR PHARM DESIGN, V17, P4089, DOI 10.2174/138161211798764843
   Tune JD, 2017, TRANSL RES, V183, P57, DOI 10.1016/j.trsl.2017.01.001
   Ueba H, 2005, ATHEROSCLEROSIS, V183, P35, DOI 10.1016/j.atherosclerosis.2005.01.055
   Ussher JR, 2012, ENDOCR REV, V33, P187, DOI 10.1210/er.2011-1052
   Verna EC, 2008, SEMIN LIVER DIS, V28, P407, DOI 10.1055/s-0028-1091985
   Vilahur G, 2017, CARDIOVASC RES, V113, P1046, DOI 10.1093/cvr/cvx086
   Vlassara H, 2014, CURR DIABETES REP, V14, DOI 10.1007/s11892-013-0453-1
   Warboys CM, 2009, INVEST OPHTH VIS SCI, V50, P1319, DOI 10.1167/iovs.08-2730
   Wellen KE, 2003, J CLIN INVEST, V112, P1785, DOI 10.1172/JCI20514
   Williams SB, 1996, J AM COLL CARDIOL, V27, P567, DOI 10.1016/0735-1097(95)00522-6
   Wind S, 2010, HYPERTENSION, V56, P490, DOI 10.1161/HYPERTENSIONAHA.109.149187
   Wu JZ, 2016, DIABET METAB SYND OB, V9, P145, DOI 10.2147/DMSO.S106087
   Yisireyili M, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-01366-3
   Yudkin JS, 2005, LANCET, V365, P1817, DOI 10.1016/S0140-6736(05)66585-3
   Zeng GY, 1996, J CLIN INVEST, V98, P894, DOI 10.1172/JCI118871
   Zeng GY, 2000, CIRCULATION, V101, P1539, DOI 10.1161/01.CIR.101.13.1539
NR 218
TC 28
Z9 29
U1 0
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD JAN 20
PY 2019
VL 30
IS 3
BP 333
EP 353
DI 10.1089/ars.2017.7421
EA JAN 2018
PG 21
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA HE5CS
UT WOS:000422647400001
PM 29084432
DA 2025-06-11
ER

PT J
AU Bradley, JM
   Islam, KN
   Polhemus, DJ
   Donnarumma, E
   Brewster, LP
   Tao, YX
   Goodchild, TT
   Lefer, DJ
AF Bradley, Jessica M.
   Islam, Kazi N.
   Polhemus, David J.
   Donnarumma, Erminia
   Brewster, Luke P.
   Tao, Ya-Xiong
   Goodchild, Traci T.
   Lefer, David J.
TI Sustained release nitrite therapy results in myocardial protection in a
   porcine model of metabolic syndrome with peripheral vascular disease
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE Ossabaw swine; endothelial dysfunction; atherosclerosis; nitric oxide;
   sustained-release sodium nitrite
ID CORONARY-HEART-DISEASE; SYSTEMIC OXIDATIVE STRESS; ENDOTHELIAL
   DYSFUNCTION; OXIDE SYNTHASE; ASYMMETRIC DIMETHYLARGININE;
   ARTERIAL-DISEASE; CARDIOVASCULAR-DISEASE; ISCHEMIA; NITRATE; EVENTS
AB Metabolic syndrome (MetS) reduces endothelial nitric oxide (NO) bioavailability and exacerbates vascular dysfunction in patients with preexisting vascular diseases. Nitrite, a storage form of NO, can mediate vascular function during pathological conditions when endogenous NO is reduced. The aims of the present study were to characterize the effects of severe MetS and obesity on dyslipidemia, myocardial oxidative stress, and endothelial NO synthase (eNOS) regulation in the obese Ossabaw swine (OS) model and to examine the effects of a novel, sustained-release formulation of sodium nitrite (SR-nitrite) on coronary vascular reactivity and myocardial redox status in obese OS subjected to critical limb ischemia (CLI). After 6 mo of an atherogenic diet, obese OS displayed a MetS phenotype. Obese OS had decreased eNOS functionality and NO bioavailability. In addition, obese OS exhibited increased oxidative stress and a significant reduction in antioxidant enzymes. The efficacy of SR-nitrite therapy was examined in obese OS subjected to CLI. After 3 wk of treatment, SR-nitrite (80 mg.kg(-1).day(-1) bid po) increased myocardial nitrite levels and eNOS function. Treatment with SR-nitrite reduced myocardial oxidative stress while increasing myocardial antioxidant capacity. Ex vivo assessment of vascular reactivity of left anterior descending coronary artery segments demonstrated marked improvement in vasoreactivity to sodium nitroprusside but not to substance P and bradykinin in SR-nitrite-treated animals compared with placebo-treated animals. In conclusion, in a clinically relevant, large-animal model of MetS and CLI, treatment with SR-nitrite enhanced myocardial NO bioavailability, attenuated oxidative stress, and improved ex vivo coronary artery vasorelaxation.
C1 [Bradley, Jessica M.; Islam, Kazi N.; Polhemus, David J.; Donnarumma, Erminia; Goodchild, Traci T.; Lefer, David J.] Louisiana State Univ, Hlth Sci Ctr, Cardiovasc Ctr Excellence, New Orleans, LA 70112 USA.
   [Bradley, Jessica M.; Islam, Kazi N.; Polhemus, David J.; Donnarumma, Erminia; Goodchild, Traci T.; Lefer, David J.] Louisiana State Univ, Hlth Sci Ctr, Dept Pharmacol, New Orleans, LA 70112 USA.
   [Brewster, Luke P.] Emory Univ, Sch Med, Dept Surg, Atlanta, GA 30322 USA.
   [Brewster, Luke P.] Atlanta Vet Affairs Med Ctr, Surg & Res Serv, Decatur, GA USA.
   [Brewster, Luke P.] Georgia Inst Technol, Parker H Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA.
   [Tao, Ya-Xiong] Auburn Univ, Coll Vet Med, Dept Anat Physiol & Pharmacol, Auburn, AL 36849 USA.
C3 Louisiana State University System; Louisiana State University Health
   Sciences Center New Orleans; Louisiana State University System;
   Louisiana State University Health Sciences Center New Orleans; Emory
   University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Atlanta VA Health Care System; University System
   of Georgia; Georgia Institute of Technology; Auburn University System;
   Auburn University
RP Bradley, JM (corresponding author), Louisiana State Univ, Hlth Sci Ctr, Cardiovasc Ctr Excellence, 533 Bolivar St,Suite 408, New Orleans, LA 70112 USA.
EM dlefe1@lsuhsc.edu
RI Lefer, David/A-6372-2012; Tao, Ya-Xiong/K-4939-2019
OI Tao, Ya-Xiong/0000-0003-4737-749X; Lefer, David/0000-0003-2293-7278;
   Donnarumma, Erminia/0000-0003-2184-5144
FU National Institutes of Health (NIH) [1-R01-HL-092141, 1-R01-HL-093579,
   1-U24-HL-094373, 1-P20-HL-113452, 1-KO8-HL-119592]; NIH [UL1-TR-000454];
   American Heart Association [13IRG14740001]; Carlyle Fraser Heart Center
   at Emory University Midtown Hospital; Emory University Department of
   Surgery; Louisiana State University Medical School Alumni Association;
   American Heart Association (AHA) [13IRG14740001] Funding Source:
   American Heart Association (AHA)
FX This work was supported by National Institutes of Health (NIH) Grants
   1-R01-HL-092141 (to D. J. Lefer), 1-R01-HL-093579 (to D. J. Lefer),
   1-U24-HL-094373 (to D. J. Lefer), 1-P20-HL-113452 (to D. J. Lefer), and
   1-KO8-HL-119592 (to L. P. Brewster) and supported in part by NIH Grant
   UL1-TR-000454 from the Clinical and Translational Science Award Program
   (to L. P. Brewster) and American Heart Association Grant 13IRG14740001
   (to L. P. Brewster). The authors are also grateful for the generous
   funding from the Carlyle Fraser Heart Center at Emory University Midtown
   Hospital, the Emory University Department of Surgery, and the Louisiana
   State University Medical School Alumni Association.
CR Agouni A, 2008, AM J PATHOL, V173, P1210, DOI 10.2353/ajpath.2008.080228
   Al Suwaidi J, 2000, CIRCULATION, V101, P948, DOI 10.1161/01.CIR.101.9.948
   Bhushan S, 2014, CIRC RES, V114, P1281, DOI 10.1161/CIRCRESAHA.114.301475
   Böger RH, 1998, CIRCULATION, V98, P1842, DOI 10.1161/01.CIR.98.18.1842
   Boo YC, 2002, J BIOL CHEM, V277, P3388, DOI 10.1074/jbc.M108789200
   Brevetti G, 2003, CIRCULATION, V108, P2093, DOI 10.1161/01.CIR.0000095273.92468.D9
   Bryan NS, 2007, P NATL ACAD SCI USA, V104, P19144, DOI 10.1073/pnas.0706579104
   Cai H, 2000, CIRC RES, V87, P840, DOI 10.1161/01.RES.87.10.840
   Carlström M, 2010, P NATL ACAD SCI USA, V107, P17716, DOI 10.1073/pnas.1008872107
   Cooke JP, 2000, ARTERIOSCL THROM VAS, V20, P2032, DOI 10.1161/01.ATV.20.9.2032
   Cosby K, 2003, NAT MED, V9, P1498, DOI 10.1038/nm954
   Dyson MC, 2006, COMPARATIVE MED, V56, P35
   Elrod JW, 2008, P NATL ACAD SCI USA, V105, P11430, DOI 10.1073/pnas.0800700105
   Froehlich JB, 2006, AM HEART J, V151, P1123, DOI 10.1016/j.ahj.2005.11.005
   Fujita K, 2006, CIRC J, V70, P1437, DOI 10.1253/circj.70.1437
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gokce N, 2003, J AM COLL CARDIOL, V41, P1769, DOI 10.1016/S0735-1097(03)00333-4
   Gorter PM, 2004, ATHEROSCLEROSIS, V173, P363, DOI 10.1016/j.atherosclerosis.2003.12.033
   Greenstein AS, 2009, CIRCULATION, V119, P1661, DOI 10.1161/CIRCULATIONAHA.108.821181
   Heitzer T, 2001, CIRCULATION, V104, P2673, DOI 10.1161/hc4601.099485
   Hooi JD, 2004, J CLIN EPIDEMIOL, V57, P294, DOI 10.1016/j.jclinepi.2003.09.003
   Hooi JD, 1999, BRIT J GEN PRACT, V49, P49
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   King AL, 2014, P NATL ACAD SCI USA, V111, P3182, DOI 10.1073/pnas.1321871111
   Lee L, 2009, HEPATOLOGY, V50, P56, DOI 10.1002/hep.22904
   Lin KY, 2002, CIRCULATION, V106, P987, DOI 10.1161/01.CIR.0000027109.14149.67
   Lin MI, 2003, J BIOL CHEM, V278, P44719, DOI 10.1074/jbc.M302836200
   Lloyd-Jones D, 2010, CIRCULATION, V121, P948, DOI 10.1161/CIRCULATIONAHA.109.192666
   Lorenzo C, 2007, DIABETES CARE, V30, P8, DOI 10.2337/dc06-1414
   LOSCALZO J, 1995, PROG CARDIOVASC DIS, V38, P87, DOI 10.1016/S0033-0620(05)80001-5
   Lundberg JO, 2008, NAT REV DRUG DISCOV, V7, DOI [10.1038/nrd2466-c2, 10.1038/nrd2466]
   Lundberg JO, 2009, NAT CHEM BIOL, V5, P865, DOI 10.1038/nchembio.260
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Marchesi C, 2009, HYPERTENSION, V54, P1384, DOI 10.1161/HYPERTENSIONAHA.109.138305
   Mount PF, 2007, J MOL CELL CARDIOL, V42, P271, DOI 10.1016/j.yjmcc.2006.05.023
   Neeb ZP, 2010, COMPARATIVE MED, V60, P300
   Nicholson CK, 2013, J MOL CELL CARDIOL, V64, P1, DOI 10.1016/j.yjmcc.2013.08.002
   Olijhoek JK, 2004, EUR HEART J, V25, P342, DOI 10.1016/j.ehj.2003.12.007
   Owen MK, 2013, CIRCULATION, V128, P9, DOI 10.1161/CIRCULATIONAHA.112.001238
   Payne GA, 2010, ARTERIOSCL THROM VAS, V30, P1711, DOI 10.1161/ATVBAHA.110.210070
   Polhemus DJ, 2015, AM J PHYSIOL-HEART C, V309, pH82, DOI 10.1152/ajpheart.00115.2015
   Roberts CK, 2006, METABOLISM, V55, P928, DOI 10.1016/j.metabol.2006.02.022
   Schillaci G, 2005, HYPERTENSION, V45, P1078, DOI 10.1161/01.HYP.0000165313.84007.7d
   Sindler AL, 2011, AGING CELL, V10, P429, DOI 10.1111/j.1474-9726.2011.00679.x
   Wang D, 2009, AM J PHYSIOL-REG I, V296, pR195, DOI 10.1152/ajpregu.90506.2008
   Yilmaz MI, 2006, AM J KIDNEY DIS, V47, P42, DOI 10.1053/j.ajkd.2005.09.029
NR 46
TC 16
Z9 16
U1 0
U2 6
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD JUL 15
PY 2015
VL 309
IS 2
BP H305
EP H317
DI 10.1152/ajpheart.00163.2015
PG 13
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA CM8YO
UT WOS:000357990200008
PM 25957218
OA Green Published
DA 2025-06-11
ER

PT J
AU Li, HX
   Zhou, B
   Xu, L
   Liu, JL
   Zang, WJ
   Wu, SF
   Sun, HZ
AF Li, Huixia
   Zhou, Bo
   Xu, Lin
   Liu, Jiali
   Zang, Weijin
   Wu, Shufang
   Sun, Hongzhi
TI Circulating PGRN Is Significantly Associated With Systemic Insulin
   Sensitivity and Autophagic Activity in Metabolic Syndrome
SO ENDOCRINOLOGY
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; FRONTOTEMPORAL LOBAR DEGENERATION;
   ADIPOKINE PROGRANULIN DEPEND; FACTOR-KAPPA-B; ADIPOSE-TISSUE;
   GROWTH-FACTOR; ER STRESS; EPITHELIN PRECURSOR; ADIPOGENIC GENES; MTOR
   INHIBITION
AB Progranulin (PGRN) is a secreted protein that has recently emerged as an important regulatory adipokine of glucose metabolism and insulin sensitivity. We report here that serum PGRN concentrations were significantly higher in patients with metabolic syndrome (MS) than in subjects without MS and correlated positively with body mass index, waist circumference, fasting insulin, fasting plasma glucose, glycated hemoglobin A(1c), triglyceride, and homeostasis model assessment of insulin resistance, and were inversely related to high-density lipoprotein cholesterol and homeostasis model assessment of beta cell function. Subgroup analysis in 32 subjects showed that elevated expression levels of PGRN were positively correlated with increased autophagy markers LC3 and Atg7 proteins in omental adipose tissue of subjects with MS. Consistent with these findings, the enhanced PGRN levels were also observed in multiple insulin-resistant cellular models, whereas PGRN-deficient adipocytes were more susceptible to insulin action and refractory to tunicamycin-induced autophagic disorders. PGRN remarkably attenuated insulin sensitivity, increased autophagic activity, and triggered endoplasmic reticulum (ER) stress in cultured human adipocytes, whereas these effects were nullified by reduction of ER stress with phenylbutyric acid chemical chaperone treatment. In addition, PGRN-induced ER stress and impaired insulin sensitivity were improved in TNFR1(-/-) cells, indicating a causative role of TNF receptor in the action of PGRN. Collectively, our findings suggest that circulating PGRN is significantly associated with systemic insulin sensitivity and autophagic activity in adipose tissue and support the notion that PGRN functions as a potential link between chronic inflammation and insulin resistance.
C1 [Li, Huixia; Zhou, Bo; Xu, Lin; Liu, Jiali; Zang, Weijin; Wu, Shufang; Sun, Hongzhi] Xi An Jiao Tong Univ, Affiliated Hosp 1, Sch Med, Key Lab Environm & Genes Related Dis,Minist Educ, Xian 710061, Shaanxi, Peoples R China.
C3 Xi'an Jiaotong University; Ministry of Education - China
RP Sun, HZ (corresponding author), Xi An Jiao Tong Univ, Coll Med, 76 Yanta West Rd, Xian 710061, Peoples R China.
EM shufangw@hotmail.com; sunhongzhi@mail.xjtu.edu.cn
OI Zhou, Bo/0000-0003-1467-6565
FU National Natural Science Foundation of China [30971392, 81170741,
   81071440, 81222026]; Ministry of Education, China (New Century Excellent
   Talents in University) [NCET-08-0435]
FX This work was supported by the programs from the National Natural
   Science Foundation of China (General Program 30971392, 81170741,
   81071440, and 81222026) and the the Ministry of Education, China (New
   Century Excellent Talents in University NCET-08-0435)
CR Anonymous, 2007, Zhonghua Xinxueguanbing Zazhi, V35, P390
   Baerga R, 2009, AUTOPHAGY, V5, P1118, DOI 10.4161/auto.5.8.9991
   Bossù P, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-65
   Capell A, 2011, J NEUROSCI, V31, P1885, DOI 10.1523/JNEUROSCI.5757-10.2011
   Cenik B, 2012, J BIOL CHEM, V287, P32298, DOI 10.1074/jbc.R112.399170
   Cho HJ, 2004, BIOCHEM BIOPH RES CO, V321, P942, DOI 10.1016/j.bbrc.2004.07.050
   Daniel R, 2003, DEV DYNAM, V227, P593, DOI 10.1002/dvdy.10341
   Deblon N, 2012, BRIT J PHARMACOL, V165, P2325, DOI 10.1111/j.1476-5381.2011.01716.x
   Deng J, 2004, MOL CELL BIOL, V24, P10161, DOI 10.1128/MCB.24.23.10161-10168.2004
   Dubois SG, 2006, OBESITY, V14, P1543, DOI 10.1038/oby.2006.178
   Emanuelli B, 2001, J BIOL CHEM, V276, P47944, DOI 10.1074/jbc.M104602200
   Gijselinck I, 2008, HUM MUTAT, V29, P53, DOI 10.1002/humu.20651
   Guilherme A, 2008, NAT REV MOL CELL BIO, V9, P367, DOI 10.1038/nrm2391
   He ZH, 2003, J MOL MED-JMM, V81, P600, DOI 10.1007/s00109-003-0474-3
   Hossein-Nezhad A, 2012, MINERVA ENDOCRINOL, V32, P255
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   Houde VP, 2010, DIABETES, V59, P1338, DOI 10.2337/db09-1324
   Hu SY, 2012, FEBS LETT, V586, P3485, DOI 10.1016/j.febslet.2012.07.077
   Hwang SL, 2013, BRIT J PHARMACOL, V169, P69, DOI 10.1111/bph.12124
   Jansen HJ, 2012, ENDOCRINOLOGY, V153, P5866, DOI 10.1210/en.2012-1625
   Kim KH, 2013, NAT MED, V19, P83, DOI 10.1038/nm.3014
   Klöting N, 2010, AM J PHYSIOL-ENDOC M, V299, pE506, DOI 10.1152/ajpendo.00586.2009
   Kojima Y, 2009, ATHEROSCLEROSIS, V206, P102, DOI 10.1016/j.atherosclerosis.2009.02.017
   Komatsu M, 2007, CELL, V131, P1149, DOI 10.1016/j.cell.2007.10.035
   Kouroku Y, 2007, CELL DEATH DIFFER, V14, P230, DOI 10.1038/sj.cdd.4401984
   Kovsan J, 2011, J CLIN ENDOCR METAB, V96, pE268, DOI 10.1210/jc.2010-1681
   Li HX, 2014, CELL CYCLE, V13, P565, DOI 10.4161/cc.27406
   Liu CJ, 2012, PHARMACOL THERAPEUT, V133, P124, DOI 10.1016/j.pharmthera.2011.10.003
   Matsubara T, 2012, CELL METAB, V15, P38, DOI 10.1016/j.cmet.2011.12.002
   Nadler ST, 2000, P NATL ACAD SCI USA, V97, P11371, DOI 10.1073/pnas.97.21.11371
   Ogata M, 2006, MOL CELL BIOL, V26, P9220, DOI 10.1128/MCB.01453-06
   Öst A, 2010, MOL MED, V16, P235, DOI 10.2119/molmed.2010.00023
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Pereira MJ, 2012, MOL CELL ENDOCRINOL, V355, P96, DOI 10.1016/j.mce.2012.01.024
   Qu H, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/360190
   Richter J, 2013, DIABETES CARE, V36, P410, DOI 10.2337/dc12-0220
   Riga D, 2006, ANN NY ACAD SCI, V1067, P158, DOI 10.1196/annals.1354.019
   Saitoh T, 2008, NATURE, V456, P264, DOI 10.1038/nature07383
   Shi H, 2006, DIABETES, V55, P699, DOI 10.2337/diabetes.55.03.06.db05-0841
   Shi H, 2004, J BIOL CHEM, V279, P34733, DOI 10.1074/jbc.M403886200
   Singh R, 2009, J CLIN INVEST, V119, P3329, DOI 10.1172/JCI39228
   Tang W, 2011, SCIENCE, V332, P478, DOI 10.1126/science.1199214
   Tönjes A, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013911
   Triebel J, 2013, DIABETES CARE, V36, pE83, DOI 10.2337/dc12-2275
   Ueki K, 2004, MOL CELL BIOL, V24, P5434, DOI 10.1128/MCB.24.12.5434-5446.2004
   van Harmelen V, 2003, INT J OBESITY, V27, P889, DOI 10.1038/sj.ijo.0802314
   Wang JR, 2009, J BIOL CHEM, V284, P21412, DOI 10.1074/jbc.M109.026013
   Wong MCS, 2008, J HUM HYPERTENS, V22, P648, DOI 10.1038/jhh.2008.46
   Wu SF, 2011, J BIOL CHEM, V286, P24057, DOI 10.1074/jbc.M110.201368
   Yang L, 2010, CELL METAB, V11, P467, DOI 10.1016/j.cmet.2010.04.005
   Yoo HJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055744
   Youn BS, 2009, DIABETES, V58, P627, DOI 10.2337/db08-1147
   Zhang Y, 2009, P NATL ACAD SCI USA, V106, P19860, DOI 10.1073/pnas.0906048106
   Zhao WH, 2007, BIOMED ENVIRON SCI, V20, P329
   Zhou B, 2013, ENDOCRINOLOGY, V154, P1055, DOI 10.1210/en.2012-2144
NR 55
TC 42
Z9 44
U1 0
U2 12
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD SEP
PY 2014
VL 155
IS 9
BP 3493
EP 3507
DI 10.1210/en.2014-1058
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AP8QQ
UT WOS:000342344300028
PM 24971611
OA Bronze
DA 2025-06-11
ER

PT J
AU Ruiz-Ramírez, A
   Ortiz-Balderas, E
   Gardozo-Saldaña, G
   Diaz-Diaz, E
   El-Hafidi, M
AF Ruiz-Ramirez, Angelica
   Ortiz-Balderas, Ely
   Gardozo-Saldana, Guillermo
   Diaz-Diaz, Eulises
   El-Hafidi, Mohammed
TI Glycine restores glutathione and protects against oxidative stress in
   vascular tissue from sucrose-fed rats
SO CLINICAL SCIENCE
LA English
DT Article
DE endothelial dysfunction; glutathione; nitric oxide; obesity; oxidative
   stress; vascular complication
ID FREE FATTY-ACIDS; METABOLIC SYNDROME; NAD(P)H OXIDASE; NITRIC-OXIDE;
   IN-VIVO; ENDOTHELIAL DYSFUNCTION; BUTHIONINE SULFOXIMINE; DIETARY
   GLYCINE; NADPH OXIDASES; BLOOD-PRESSURE
AB The attenuation of oxidative stress could be an important mechanism whereby the incidence of vascular complications in the MS (metabolic syndrome) may be diminished. The present study was undertaken to investigate the mechanism by which glycine, supplemented to the diet of SF (sucrose-fed) rats, modulates glutathione biosynthesis and protects against oxidative stress and altered endothelium-dependent relaxation in isolated aorta. Glycine reduced O-2(center dot-) (superoxide anion radical) release in the presence of NADPH, and decreased protein carbonyl and lipid peroxidation. This effect of glycine could be because of the increased amount of glutathione synthetase, which may be responsible for increased glutathione (GSH) content in vascular tissue from SF rats. Moreover, glycine increased the amount of Cu,Zn-SOD (copper/zinc superoxide dismutase) and eNOS (endothelial NO synthase) in aorta from SF animals. Finally, it improved the relaxation response to ACh (acetylcholine) found impaired in aortic rings from SF rats. In the presence of NAC (N-acetylcysteine), a precursor of GSH, an improved ACh-mediated aortic relaxation of aortic rings from SF rats was observed, whereas BSO (buthionine sulfoximine), an inhibitor of glutathione biosynthesis, inhibited the relaxing effect of NAC in aortas from both control and SF rats. This experiment emphasizes the role of GSH in endothelial function in SF rats. The present data suggest that glycine rectifies vascular reactivity by increasing the biosynthesis of glutathione. Glutathione protects vascular tissue against oxidative stress, and enhances the availability of NO, which exerts its relaxing effect, thus contributing to the reduction of high BP (blood pressure) in the SF rats.
C1 [Ruiz-Ramirez, Angelica; Ortiz-Balderas, Ely; El-Hafidi, Mohammed] Inst Nacl Cardiol Ignacio Chavez, Dept Cardiovasc Biomed, Mexico City 14080, DF, Mexico.
   [Gardozo-Saldana, Guillermo] Inst Nacl Cardiol Ignacio Chavez, Dept Endocrinol, Mexico City 14080, DF, Mexico.
   [Diaz-Diaz, Eulises] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Mexico City 14000, DF, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico; Instituto Nacional de Ciencias Medicas y Nutricion
   Salvador Zubiran - Mexico
RP El-Hafidi, M (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Cardiovasc Biomed, Juan Badiano 1,Col Secc 16, Mexico City 14080, DF, Mexico.
EM medelhafidi@yahoo.com
RI El-Hafidi, Mohammed/AAN-4083-2021
FU Institut de Ciencia y Tecnologia del Distrito Federal, Mexico City
   (ICyTDF) [PICDS08-67]; Consejo Nacional de Ciencia y Tecnologia
   (CONACyT) [1068451]
FX This work was supported in part by the Institut de Ciencia y Tecnologia
   del Distrito Federal, Mexico City (ICyTDF) [grant number PICDS08-67] and
   by Consejo Nacional de Ciencia y Tecnologia (CONACyT) [grant number
   1068451.
CR Banos G, 1997, AM J HYPERTENS, V10, P379
   Bedard K, 2007, PHYSIOL REV, V87, P245, DOI 10.1152/physrev.00044.2005
   Bouloumié A, 1999, FASEB J, V13, P1231, DOI 10.1096/fasebj.13.10.1231
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Brandes RP, 2010, FREE RADICAL BIO MED, V49, P687, DOI 10.1016/j.freeradbiomed.2010.04.030
   Brawley L, 2004, J PHYSIOL-LONDON, V554, P497, DOI 10.1113/jphysiol.2003.052068
   Cardona F, 2008, EUR J CLIN INVEST, V38, P510, DOI 10.1111/j.1365-2362.2008.01959.x
   Chen CA, 2010, NATURE, V468, P1115, DOI 10.1038/nature09599
   Cohen RA, 2010, J CARDIOVASC PHARM, V55, P308, DOI 10.1097/FJC.0b013e3181d89670
   Ferro FED, 2011, BIOL TRACE ELEM RES, V143, P787, DOI 10.1007/s12011-010-8940-6
   El Hafidi M, 2006, CURR OPIN CLIN NUTR, V9, P26, DOI 10.1097/01.mco.0000196143.72985.9a
   El Hafidi M, 2004, AM J PHYSIOL-REG I, V287, pR1387, DOI 10.1152/ajpregu.00159.2004
   El Hafidi M, 2006, CLIN EXP HYPERTENS, V28, P669, DOI 10.1080/10641960601013617
   ElHafidi M, 1997, HYPERTENSION, V30, P624, DOI 10.1161/01.HYP.30.3.624
   Elshorbagy AK, 2012, NUTR METAB CARDIOVAS, V22, P1031, DOI 10.1016/j.numecd.2011.01.008
   Elshorbagy AK, 2012, J NUTR BIOCHEM, V23, P332, DOI 10.1016/j.jnutbio.2010.12.009
   Elshorbagy AK, 2012, CURR OPIN CLIN NUTR, V15, P49, DOI 10.1097/MCO.0b013e32834d199f
   Folch L, 1957, J BIOL CHEM, V22, P697
   Ford RJ, 2006, FREE RADICAL BIO MED, V40, P670, DOI 10.1016/j.freeradbiomed.2005.09.020
   Franco R., 2007, Archives of Physiology and Biochemistry, V113, P234, DOI 10.1080/13813450701661198
   Giral P, 2008, ARTERIOSCL THROM VAS, V28, P587, DOI 10.1161/ATVBAHA.107.157891
   Gokce G, 2009, BIOCHEMISTRY-US, V48, P4980, DOI 10.1021/bi900030z
   GREKIN RJ, 1995, HYPERTENSION, V26, P193, DOI 10.1161/01.HYP.26.1.193
   GRIMBLE RF, 1992, J NUTR, V122, P2066, DOI 10.1093/jn/122.11.2066
   Guzik TJ, 2000, CIRC RES, V86, pE85, DOI 10.1161/01.RES.86.9.e85
   Inoguchi T, 2000, DIABETES, V49, P1939, DOI 10.2337/diabetes.49.11.1939
   JACKSON AA, 1991, EUR J CLIN NUTR, V45, P59
   Korda M, 2008, AM J PHYSIOL-HEART C, V295, pH1514, DOI 10.1152/ajpheart.00479.2008
   Kwon YH, 2001, AM J PHYSIOL-ENDOC M, V280, pE804, DOI 10.1152/ajpendo.2001.280.5.E804
   LEVINE RL, 1990, METHOD ENZYMOL, V186, P464
   Lu SC, 2000, CURR TOP CELL REGUL, V36, P95
   MacMillan-Crow LA, 1998, BIOCHEMISTRY-US, V37, P1613, DOI 10.1021/bi971894b
   McIntyre M, 1999, HYPERTENSION, V34, P539, DOI 10.1161/01.HYP.34.4.539
   Mikalauskas S, 2011, AMINO ACIDS, V40, P1139, DOI 10.1007/s00726-010-0737-6
   Montezano AC, 2012, CAN J CARDIOL, V28, P288, DOI 10.1016/j.cjca.2012.01.017
   Muller G, 2009, ANTIOXID REDOX SIGN, V11, P1711, DOI [10.1089/ars.2008.2403, 10.1089/ARS.2008.2403]
   NAGELE U, 1984, J CLIN CHEM CLIN BIO, V22, P165
   Pastore A, 2012, PEDIATR DIABETES, V13, P272, DOI 10.1111/j.1399-5448.2011.00806.x
   Pérez-Torres I, 2009, FREE RADICAL RES, V43, P761, DOI 10.1080/10715760903045296
   Persaud C, 1996, J NUTR, V126, P2823
   Roberts CK, 2006, METABOLISM, V55, P928, DOI 10.1016/j.metabol.2006.02.022
   Ruiz-Ramírez A, 2011, AM J PHYSIOL-ENDOC M, V301, pE1198, DOI 10.1152/ajpendo.00631.2010
   Sarr M, 2011, CARDIOVASC J AFR, V22, P7
   Sastry KVH, 2002, ANAL BIOCHEM, V306, P79, DOI 10.1006/abio.2002.5676
   Sekhar RV, 2011, AM J CLIN NUTR, V94, P847, DOI 10.3945/ajcn.110.003483
   Sekhar RV, 2011, DIABETES CARE, V34, P162, DOI 10.2337/dc10-1006
   Silberman GA, 2010, CIRCULATION, V121, P519, DOI 10.1161/CIRCULATIONAHA.109.883777
   Skalicky J, 2008, CLIN CHEM LAB MED, V46, P499, DOI 10.1515/CCLM.2008.096
   Srivastava P, 1998, PHARMACOL RES, V38, P265, DOI 10.1006/phrs.1998.0357
   SUZUKI H, 1995, HYPERTENSION, V25, P1083, DOI 10.1161/01.HYP.25.5.1083
   Sweazea KL, 2010, NUTR METAB, V7, DOI 10.1186/1743-7075-7-48
   TODOKI K, 1992, AM J PHYSIOL, V262, pH806, DOI 10.1152/ajpheart.1992.262.3.H806
   TSERNG KY, 1981, J LIPID RES, V22, P852
   Vargas F, 2012, AM J HYPERTENS, V25, P629, DOI 10.1038/ajh.2011.240
   Vaziri ND, 2000, HYPERTENSION, V36, P142, DOI 10.1161/01.HYP.36.1.142
   Vecchione C, 2002, DIABETES, V51, P168, DOI 10.2337/diabetes.51.1.168
   Vincent HK, 2007, DIABETES OBES METAB, V9, P813, DOI 10.1111/j.1463-1326.2007.00692.x
   Yin M, 1998, J PHARMACOL EXP THER, V286, P1014
   Yu YM, 2002, AM J PHYSIOL-ENDOC M, V282, pE247, DOI 10.1152/ajpendo.00206.2001
   Zhong Z, 1999, MOL PHARMACOL, V56, P455, DOI 10.1124/mol.56.3.455
   Zweier JL, 2011, ANTIOXID REDOX SIGN, V14, P1769, DOI 10.1089/ars.2011.3904
NR 61
TC 81
Z9 90
U1 0
U2 33
PU PORTLAND PRESS LTD
PI LONDON
PA CHARLES DARWIN HOUSE, 12 ROGER STREET, LONDON WC1N 2JU, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD JAN
PY 2014
VL 126
IS 1-2
BP 19
EP 29
DI 10.1042/CS20130164
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 297MA
UT WOS:000330258400002
PM 23742196
DA 2025-06-11
ER

PT J
AU Santillán, LD
   Moyano, M
   Frau, M
   Flores, O
   Siewert, S
   Zirulnick, F
   Ramirez, DC
   Giménez, MS
AF Santillan, Lucas D.
   Moyano, Marta
   Frau, Martin
   Flores, Orlando
   Siewert, Susana
   Zirulnick, Fanny
   Ramirez, Dario C.
   Gimenez, Maria S.
TI Reduced Blood Nrf-2 mRNA in Local Overweight Boys at Risk of Metabolic
   Complications: A Study in San Luis City, San Luis, Argentina
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; PROTEIN CARBONYLS;
   GENE-EXPRESSION; PLASMA; OBESITY; ACTIVATION; PATHWAY; MARKERS; TARGET
AB Background: Childhood overweight (OW) is a matter of public health concern because of its long-term impact on adulthood health. NF-E2-related factor 2 (Nrf-2) regulates the antioxidant/lipogenic response to a sustained positive energy balance that prevails during weight gain. Here we aimed at studying a possible link between OW and Nrf-2-dependent antioxidant/lipogenic response in a local population of boys at risk of metabolic complications. Methods: We measured clinical and biochemical parameters related to lipid metabolism, oxidative stress, and metabolic syndrome in a population of OW boys [body mass index (BMI) percentile 85(th) and <95(th), n=22] and normal weight boys (NW; BMI percentile<85(th), n=27) from San Luis City, San Luis, Argentina. Results: Compared to NW, OW boys had lower insulin sensitivity, an altered plasma lipid profile, and increased markers of oxidative stress and inflammatory fatty acids. OW boys also had a higher atherogenic index and peripheral insulin resistance than NW boys. We also found that glutathione peroxidase activity and the reduced glutathione to oxidized glutathione ratio were lower in OW boys than NW boys, suggesting that OW boys may have an altered antioxidant response to oxidative stress. Finally, Nrf-2 expression negatively correlated with metabolic syndrome parameters in OW boys. Conclusions: Our data suggest that OW boys have a reduced antioxidant and lipogenic response to a positive energy balance, resulting in oxidative stress, insulin resistance, and risk of developing metabolic complications. Our data also provide a rationale for nutritional interventions aimed at restoring Nrf-2 expression to reduce the risk of metabolic complications in OW boys.
C1 [Santillan, Lucas D.; Zirulnick, Fanny; Gimenez, Maria S.] Natl Univ San Luis, Lab Pathol & Biol Chem, Dept Biochem & Biol Sci, RA-5700 San Luis, Argentina.
   [Santillan, Lucas D.; Zirulnick, Fanny; Gimenez, Maria S.] IMIBIO SL CONICET, San Luis, Argentina.
   [Moyano, Marta] San Luis Reg Hosp, Minist Hlth,Prov San Luis, San Luis, Argentina.
   [Frau, Martin; Flores, Orlando] Private Med Ctr San Luis, San Luis, Argentina.
   [Siewert, Susana] Natl Univ San Luis, Lab Diabet, RA-5700 San Luis, Argentina.
   [Ramirez, Dario C.] Natl Univ San Luis, Lab Expt & Therapeut Med IMIBIO SL CONICET, RA-5700 San Luis, Argentina.
   [Ramirez, Dario C.] Natl Univ San Luis, Dept Biochem & Biol Sci, RA-5700 San Luis, Argentina.
C3 Universidad Nacional de San Luis; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Universidad Nacional de San Luis;
   Universidad Nacional de San Luis; Universidad Nacional de San Luis
RP Giménez, MS (corresponding author), Natl Univ San Luis, IMIBIO SL CONICET, Ave Ejercito Andes 950, RA-5700 San Luis, Argentina.
EM ramirezlabimibiosl@ymail.com; marisofigime44@gmail.com
RI Flores, Orlando/AAT-1887-2020; RAMIREZ, DARIO/K-3312-2013
OI RAMIREZ, DARIO/0000-0001-6725-3326; Gimenez, Maria
   Sofia/0000-0003-1312-0661
FU National University of San Luis [8104]; PIP CONICET [4931]
FX Authors thank Sandra E. Gomez-Mejiba for helping in the editing of this
   manuscript and Dr. Isabel Gimenez for assistance with statistical
   analyses. D. C. R. is an affiliate Investigator of the National
   Institute of Environmental Health Sciences, National Institutes of
   Health, U.S. Department of Health and Human Services. This research was
   supported by the National University of San Luis to M. S. G. (grant
   #8104: Nutrition, Environment and Cell Metabolism) and PIP CONICET 4931
   to M.S.G.
CR AEBI H, 1984, METHOD ENZYMOL, V105, P121
   Akerboom T P, 1981, Methods Enzymol, V77, P373
   Azekoshi Y, 2010, HYPERTENSION, V56, P136, DOI 10.1161/HYPERTENSIONAHA.110.153056
   Baer HJ, 2007, CANCER EPIDEM BIOMAR, V16, P1880, DOI 10.1158/1055-9965.EPI-07-0313
   Banning A, 2005, MOL CELL BIOL, V25, P4914, DOI 10.1128/MCB.25.12.4914-4923.2005
   Beltowski J, 2005, PHARMACOL RES, V51, P523, DOI 10.1016/j.phrs.2005.01.007
   Bloch-Damti A, 2005, ANTIOXID REDOX SIGN, V7, P1553, DOI 10.1089/ars.2005.7.1553
   Chartoumpekis DV, 2011, DIABETES, V60, P2465, DOI 10.2337/db11-0112
   Crespo PS, 2007, PUBLIC HEALTH NUTR, V10, P1121, DOI 10.1017/S1368980007000596
   Das SK, 2011, J CLIN ENDOCR METAB, V96, pE1308, DOI 10.1210/jc.2011-0101
   de Assis AAA, 2007, BRIT J NUTR, V97, P799, DOI 10.1017/S0007114507657936
   FLOHE L, 1984, METHOD ENZYMOL, V105, P114
   Fortuño A, 2006, DIABETES, V55, P209, DOI 10.2337/diabetes.55.1.209
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Halfon N, 2012, PEDIATR REV, V33, P51, DOI 10.1542/pir.33-2-51
   Huang JS, 2010, AM J PHYSIOL-GASTR L, V299, pG1211, DOI 10.1152/ajpgi.00322.2010
   Jentzsch AM, 1996, FREE RADICAL BIO MED, V20, P251, DOI 10.1016/0891-5849(95)02043-8
   Kobayashi A, 2004, MOL CELL BIOL, V24, P7130, DOI 10.1128/MCB.24.16.7130-7139.2004
   LEVINE RL, 1994, METHOD ENZYMOL, V233, P346
   Madeira IR, 2009, J PEDIAT-BRAZIL, V85, P261, DOI 10.2223/JPED.1873
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Motohashi H, 2004, TRENDS MOL MED, V10, P549, DOI 10.1016/j.molmed.2004.09.003
   Natl High Blood Pressure Educ Prog, 2004, PEDIATRICS, V114, P555
   Ness-Abramof R, 2008, NUTR CLIN PRACT, V23, P397, DOI 10.1177/0884533608321700
   Onat A, 2010, J CLIN LIPIDOL, V4, P89, DOI 10.1016/j.jacl.2010.02.005
   Ragheb R, 2009, BIOCHEM BIOPH RES CO, V389, P211, DOI 10.1016/j.bbrc.2009.08.106
   Schmid H, 2003, KIDNEY INT, V64, P356, DOI 10.1046/j.1523-1755.2003.00074.x
   Solinas G, 2010, FASEB J, V24, P2596, DOI 10.1096/fj.09-151340
   van Dijk SJ, 2009, AM J CLIN NUTR, V90, P1656, DOI 10.3945/ajcn.2009.27792
   Vomhof-DeKrey EE, 2012, J NUTR BIOCHEM, V23, P1201, DOI 10.1016/j.jnutbio.2012.03.005
   Wang Y, 2006, INT J PEDIATR OBES, V1, P11, DOI 10.1080/17477160600586747
   Winterbourn CC, 2000, PEDIATR RES, V48, P84, DOI 10.1203/00006450-200007000-00015
   Winterbourn CC, 2003, PANCREATOLOGY, V3, P375, DOI 10.1159/000073652
   Yu Z, 2011, DIABETOLOGIA, V54, P922, DOI 10.1007/s00125-010-2001-8
   Zaldivar F, 2006, INT J OBESITY, V30, P906, DOI 10.1038/sj.ijo.0803227
NR 35
TC 4
Z9 4
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD OCT 1
PY 2013
VL 11
IS 5
BP 359
EP 365
DI 10.1089/met.2012.0155
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 220JZ
UT WOS:000324580800009
PM 23809001
OA Green Published
DA 2025-06-11
ER

PT J
AU Glaus, J
   Kang, SJ
   Guo, W
   Lamers, F
   Strippoli, MPF
   Leroux, A
   Dey, D
   Plessen, KJ
   Vaucher, J
   Vollenweider, P
   Zipunnikov, V
   Merikangas, KR
   Preisig, M
AF Glaus, Jennifer
   Kang, Sun Jung
   Guo, Wei
   Lamers, Femke
   Strippoli, Marie-Pierre F.
   Leroux, Andrew
   Dey, Debangan
   Plessen, Kerstin J.
   Vaucher, Julien
   Vollenweider, Peter
   Zipunnikov, Vadim
   Merikangas, Kathleen R.
   Preisig, Martin
TI Objectively assessed sleep and physical activity in depression subtypes
   and its mediating role in their association with cardiovascular risk
   factors
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Depressive disorder subtypes; Atypical depression; BMI; Metabolic
   syndrome; Actigraphy; Epidemiology
ID METABOLIC SYNDROME; DIAGNOSTIC INTERVIEW; INFLAMMATORY MARKERS; ATYPICAL
   FEATURES; DISORDERS; DISTURBANCES; SYMPTOMS; MOOD; METAANALYSIS;
   RELIABILITY
AB The aims of this study were to investigate the associations of major depressive disorder (MDD) and its subtypes (atypical, melancholic, combined, unspecified) with actigraphy-derived measures of sleep, physical activity and circadian rhythms; and test the potentially mediating role of sleep, physical activity and circadian rhythms in the well-established associations of the atypical MDD subtype with Body Mass Index (BMI) and the metabolic syn-drome (MeS). The sample consisted of 2317 participants recruited from an urban area, who underwent comprehensive somatic and psychiatric evaluations. MDD and its subtypes were assessed via semi-structured diagnostic interviews. Sleep, physical activity and circadian rhythms were measured using actigraphy. MDD and its subtypes were associated with several actigraphy-derived variables, including later sleep midpoint, low physical activity, low inter-daily stability and larger intra-individual variability of sleep duration and relative amplitude. Sleep midpoint and physical activity fulfilled criteria for partial mediation of the association between atypical MDD and BMI, and physical activity also for partial mediation of the association between atypical MDD and MeS. Our findings confirm associations of MDD and its atypical subtype with sleep and physical activity, which are likely to partially mediate the associations of atypical MDD with BMI and MeS, although most of these associations are not explained by sleep and activity variables. This highlights the need to consider atypical MDD, sleep and sedentary behavior as cardiovascular risk factors.
C1 [Glaus, Jennifer; Plessen, Kerstin J.] Lausanne Univ Hosp CHUV, Dept Psychiat, Div Child & Adolescent Psychiat, Lausanne, Switzerland.
   [Glaus, Jennifer; Plessen, Kerstin J.; Vaucher, Julien; Vollenweider, Peter] Univ Lausanne, Lausanne, Switzerland.
   [Kang, Sun Jung; Guo, Wei; Dey, Debangan; Merikangas, Kathleen R.] Natl Inst Mental Hlth, Intramural Res Program, Genet Epidemiol Res Branch, 35 Convent Dr,MSC 3720,Bldg 35A,Room 2E422A, Bethesda, MD USA.
   [Lamers, Femke] Vrije Univ Amsterdam, Amsterdam UMC Locat, Dept Psychiat, Boelalaan 1117, Amsterdam, Netherlands.
   [Lamers, Femke] Amsterdam Publ Hlth, Mental Hlth Program, Amsterdam, Netherlands.
   [Strippoli, Marie-Pierre F.; Preisig, Martin] Lausanne Univ Hosp, Ctr Res Psychiat Epidemiol & Psychopathol, Dept Psychiat, Prilly, Switzerland.
   [Strippoli, Marie-Pierre F.; Preisig, Martin] Univ Lausanne, Prilly, Switzerland.
   [Leroux, Andrew] Univ Colorado, Dept Biostat & Informat, Anshutz Med Campus, Aurora, CO USA.
   [Vaucher, Julien; Vollenweider, Peter] Lausanne Univ Hosp, Dept Internal Med, Lausanne, Switzerland.
   [Zipunnikov, Vadim] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
   [Glaus, Jennifer] Lausanne Univ Hosp, Dept Psychiat, Div Child & Adolescent Psychiat, Ave Echallens 9, CH-1004 Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; National Institutes of Health (NIH) - USA; NIH
   National Institute of Mental Health (NIMH); Vrije Universiteit
   Amsterdam; University of Lausanne; University of Colorado System;
   University of Colorado Anschutz Medical Campus; University of Lausanne;
   Centre Hospitalier Universitaire Vaudois (CHUV); Johns Hopkins
   University; Johns Hopkins Bloomberg School of Public Health; University
   of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV)
RP Glaus, J (corresponding author), Lausanne Univ Hosp CHUV, Dept Psychiat, Div Child & Adolescent Psychiat, Lausanne, Switzerland.; Glaus, J (corresponding author), Lausanne Univ Hosp, Dept Psychiat, Div Child & Adolescent Psychiat, Ave Echallens 9, CH-1004 Lausanne, Switzerland.
EM jennifer.glaus@chuv.ch
RI Dey, Debangan/KAM-5399-2024; Glaus, Jennifer/C-7887-2017; Lamers,
   Femke/G-5161-2012; Preisig, Martin/H-3441-2016; Vaucher,
   Julien/LXB-4884-2024; Vollenweider, Peter/Q-4603-2016
OI Glaus, Jennifer/0000-0001-8883-9473; Vollenweider,
   Peter/0000-0002-0765-896X; Dey, Debangan/0000-0002-2579-5693; Vaucher,
   Julien/0000-0002-3230-3693; Strippoli, Marie-Pierre/0000-0003-3053-484X
FU National Institute of Health Intramural Research Program [ZIA MH002954];
   GlaxoSmithKline; Faculty of Biology and Medicine of Lausanne; Swiss
   National Science Foundation [3200B0-105993, 3200B0-118308,
   33CSCO-122661, 33CS30-139468, 33CS30-148401, 33CS30_177535,
   3247730_204523]; Swiss Personalized Health Network (project: Swiss Aging
   Citizen Reference)~
FX The ColausIPsyColaus study is a core site of the mobile Motor Activity
   Research Activity Consortium for Health (mMARCH) Network coordinated by
   the National Institute of Health Intramural Research Program (ZIA
   MH002954) . mMARCH team completed the data extraction, analyses and
   standardization of the administration of the mobile technology in the
   study. The ColausIPsyColaus study was supported by research grants from
   GlaxoSmithKline, the Faculty of Biology and Medicine of Lausanne, the
   Swiss National Science Foundation (grants 3200B0-105993, 3200B0-118308,
   33CSCO-122661, 33CS30-139468, 33CS30-148401, 33CS30_177535 and
   3247730_204523) and the Swiss Personalized Health Network (project:
   Swiss Aging Citizen Reference)& nbsp;
CR Abbafati C, 2020, LANCET, V396, P1135, DOI 10.1016/S0140-6736(20)31404-5
   Acker J, 2021, EPMA J, V12, P349, DOI 10.1007/s13167-021-00250-5
   Angst J, 2007, ACTA PSYCHIAT SCAND, V115, P72, DOI 10.1111/j.1600-0447.2007.00965.x
   Angst J, 2006, EUR ARCH PSY CLIN N, V256, P44, DOI 10.1007/s00406-005-0600-z
   Antonijevic IA, 2006, PSYCHONEUROENDOCRINO, V31, P1, DOI 10.1016/j.psyneuen.2005.04.004
   Association AP, 2013, Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
   Bao YP, 2017, NEUROSCI BIOBEHAV R, V75, P257, DOI 10.1016/j.neubiorev.2017.01.032
   BARON RM, 1986, J PERS SOC PSYCHOL, V51, P1173, DOI 10.1037/0022-3514.51.6.1173
   Buch AM, 2021, NEUROPSYCHOPHARMACOL, V46, P156, DOI 10.1038/s41386-020-00789-3
   Buman MP, 2014, AM J EPIDEMIOL, V179, P323, DOI 10.1093/aje/kwt292
   Cai N, 2020, HUM MOL GENET, V29, pR10, DOI 10.1093/hmg/ddaa115
   Chaplin AB, 2023, PSYCHOL MED, V53, P1049, DOI 10.1017/S0033291721002488
   Choi KW, 2019, JAMA PSYCHIAT, V76, P399, DOI 10.1001/jamapsychiatry.2018.4175
   Cizza G., 2012, PLOS
   Daghlas I, 2021, JAMA PSYCHIAT, V78, P903, DOI 10.1001/jamapsychiatry.2021.0959
   Dashti HS, 2021, ANNU REV NUTR, V41, P223, DOI 10.1146/annurev-nutr-082018-124258
   De Hert M, 2009, WORLD PSYCHIATRY, V8, P15
   Deschênes SS, 2020, EPIDEMIOL PSYCH SCI, V29, DOI 10.1017/S2045796019000441
   Di JR, 2019, STAT BIOSCI, V11, P371, DOI 10.1007/s12561-019-09236-4
   Dicker D, 2018, LANCET, V392, P1684, DOI 10.1016/s0140-6736(18)31891-9
   Difrancesco S, 2022, PSYCHOL MED, V52, P2760, DOI 10.1017/S0033291720004870
   Difrancesco S, 2019, DEPRESS ANXIETY, V36, P975, DOI 10.1002/da.22949
   Ditmars HL, 2022, PSYCHOL MED, V52, P3007, DOI 10.1017/S003329172000505X
   Duran AT, 2022, CURR CARDIOL REP, V24, P393, DOI 10.1007/s11886-022-01657-w
   ENDICOTT J, 1978, ARCH GEN PSYCHIAT, V35, P837
   Esliger DW, 2011, MED SCI SPORT EXER, V43, P1085, DOI 10.1249/MSS.0b013e31820513be
   Firmann M, 2008, BMC CARDIOVASC DISOR, V8, DOI 10.1186/1471-2261-8-6
   Fiuza-Luces C, 2018, NAT REV CARDIOL, V15, P731, DOI 10.1038/s41569-018-0065-1
   Geoffroy PA, 2018, LANCET PSYCHIAT, V5, P697, DOI 10.1016/S2215-0366(18)30254-2
   Ghaemi SN, 2011, ACTA PSYCHIAT SCAND, V124, P497, DOI 10.1111/j.1600-0447.2011.01746.x
   Glaus J, 2018, PSYCHOL MED, V48, P961, DOI 10.1017/S0033291717002744
   Glaus J, 2013, ACTA PSYCHIAT SCAND, V128, P282, DOI 10.1111/acps.12057
   Glaus J, 2014, J PSYCHIATR RES, V58, P36, DOI 10.1016/j.jpsychires.2014.07.012
   Guo W., 2022, Journal for the Measurement of Physical Behaviour, V1, P1
   Halbreich U, 2006, PSYCHONEUROENDOCRINO, V31, P16, DOI 10.1016/j.psyneuen.2005.08.004
   Häusler N, 2019, SLEEP, V42, DOI 10.1093/sleep/zsz077
   Hoevenaar-Blom MP, 2011, SLEEP, V34, P1487, DOI 10.5665/sleep.1382
   Huang TY, 2020, J AM COLL CARDIOL, V75, P991, DOI 10.1016/j.jacc.2019.12.054
   Kim LJ, 2015, SLEEP BREATH, V19, P645, DOI 10.1007/s11325-014-1070-1
   Lamers F, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.115
   Lamers F, 2013, MOL PSYCHIATR, V18, P692, DOI 10.1038/mp.2012.144
   Lasserre AM, 2017, MOL PSYCHIATR, V22, P1026, DOI 10.1038/mp.2016.178
   Lasserre AM, 2014, JAMA PSYCHIAT, V71, P880, DOI 10.1001/jamapsychiatry.2014.411
   LEBOYER M, 1991, EUR ARCH PSY CLIN N, V241, P165, DOI 10.1007/BF02219716
   Leboyer M., 1995, Interview diagnostique pour les tudes gntiques
   Lin CY, 2021, SLEEP MED, V81, P93, DOI 10.1016/j.sleep.2021.02.012
   Lopez R, 2017, SLEEP MED CLIN, V12, P395, DOI 10.1016/j.jsmc.2017.03.016
   Luik AI, 2015, DEPRESS ANXIETY, V32, P684, DOI 10.1002/da.22355
   Lyall L.M., 2018, LANCET PSYCHIATR
   MacKinnon D P, 2000, Prev Sci, V1, P173, DOI 10.1023/A:1026595011371
   Meliska CJ, 2011, PSYCHIAT RES, V188, P88, DOI 10.1016/j.psychres.2010.12.010
   Mezick EJ, 2011, SLEEP MED REV, V15, P51, DOI 10.1016/j.smrv.2010.03.001
   Migueles JH, 2022, J Meas Phys Behav, V31, P629, DOI [DOI 10.1123/JMPB.2018-0063, 10.1123/jmpb.2018-0063]
   Milaneschi Y, 2019, MOL PSYCHIATR, V24, P18, DOI 10.1038/s41380-018-0017-5
   Murray CJL, 2015, LANCET, V386, P2145, DOI 10.1016/S0140-6736(15)61340-X
   Naismith SL, 2011, ACTA NEUROPSYCHIATR, V23, P167, DOI 10.1111/j.1601-5215.2011.00555.x
   NURNBERGER JI, 1994, ARCH GEN PSYCHIAT, V51, P849, DOI 10.1001/archpsyc.1994.03950110009002
   Otte C, 2016, NAT REV DIS PRIMERS, V2, DOI 10.1038/nrdp.2016.65
   Patel JS, 2018, PSYCHOSOM MED, V80, P508, DOI 10.1097/PSY.0000000000000583
   Patnode CD, 2017, JAMA-J AM MED ASSOC, V318, P175, DOI 10.1001/jama.2017.3303
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Penninx BWJH, 2017, NEUROSCI BIOBEHAV R, V74, P277, DOI 10.1016/j.neubiorev.2016.07.003
   Preisig M, 1999, EUR ARCH PSY CLIN N, V249, P174, DOI 10.1007/s004060050084
   Preisig M, 2009, BMC PSYCHIATRY, V9, DOI 10.1186/1471-244X-9-9
   Pye J, 2021, J AFFECT DISORDERS, V281, P431, DOI 10.1016/j.jad.2020.12.034
   Resnick HE, 2003, DIABETES CARE, V26, P702, DOI 10.2337/diacare.26.3.702
   Riemann D, 2020, NEUROPSYCHOPHARMACOL, V45, P74, DOI 10.1038/s41386-019-0411-y
   Riera-Sampol A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020585
   Rock P, 2014, CHRONOBIOL INT, V31, P290, DOI 10.3109/07420528.2013.843542
   Rudaz DA, 2017, J AFFECT DISORDERS, V222, P195, DOI 10.1016/j.jad.2017.07.016
   Rykov Y, 2021, JMIR MHEALTH UHEALTH, V9, DOI 10.2196/24872
   Sartorius N, 2018, DIALOGUES CLIN NEURO, V20, P47
   Schuch F, 2017, J AFFECT DISORDERS, V210, P139, DOI 10.1016/j.jad.2016.10.050
   Schuch FB, 2018, AM J PSYCHIAT, V175, P631, DOI 10.1176/appi.ajp.2018.17111194
   Silva DA, 2020, OBES REV, V21, DOI 10.1111/obr.12966
   Silvani A, 2019, AUTON NEUROSCI-BASIC, V218, P31, DOI 10.1016/j.autneu.2019.02.006
   Takeuchi T, 2013, PSYCHIAT CLIN NEUROS, V67, P532, DOI 10.1111/pcn.12104
   Troxel WM, 2010, SLEEP, V33, P1633, DOI 10.1093/sleep/33.12.1633
   van Hees VT, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0142533
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vogelzangs N, 2014, BRAIN BEHAV IMMUN, V41, P109, DOI 10.1016/j.bbi.2014.05.004
   Woelfer M, 2019, NEUROSCIENCE, V403, P93, DOI 10.1016/j.neuroscience.2018.03.034
   Zimmet P, 2019, J INTERN MED, V286, P181, DOI 10.1111/joim.12924
NR 83
TC 6
Z9 7
U1 2
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD JUL
PY 2023
VL 163
BP 325
EP 336
DI 10.1016/j.jpsychires.2023.05.042
EA MAY 2023
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA K0TB5
UT WOS:001013647600001
PM 37253320
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Russell, JC
   Proctor, SD
   Kelly, SE
   Brindley, DN
AF Russell, James C.
   Proctor, Spencer D.
   Kelly, Sandra E.
   Brindley, David N.
TI Pair feeding-mediated changes in metabolism:: stress response and
   pathophysiology in insulin-resistant, atherosclerosis-prone JCR:LA-cp
   rats
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE metabolic syndrome; stress; fatty acids; vascular function; myocardial
   lesions
ID CARDIOVASCULAR-DISEASE; ADIPOSE-TISSUE; SERUM-INSULIN; FATTY-ACIDS;
   OBESE; TRIACYLGLYCEROL; SENSITIVITY; ZUCKER; GLUCOSE; MUSCLE
AB Rats of the JCR: LA-cp strain, which are homozygous for the cp gene (cp/cp), are obese, insulin-resistant, and hyperinsulinemic. They exhibit associated micro- and macrovascular disease and end-stage ischemic myocardial lesions and are highly stress sensitive. We subjected male cp/cp rats to pair feeding (providing the rats each day with the amount of food eaten by matched freely fed animals), a procedure that alters the diurnal feeding pattern, leading to a state of intermittent caloric restriction. Effects on insulin, glucose, and lipid metabolism, response to restraint stress, aortic contractile/relaxant response, and myocardial lesion frequency were investigated. Pair-fed young (12-wk-old) cp/cp rats had lower insulin and glucose levels (basal and following restraint), consistent with increased insulin sensitivity, but a greater increase in plasma nonesterified fatty acids in response to restraint. These effects were unrelated to lipolytic rates in adipose tissue but may be related to reduced fatty acid oxidation in skeletal muscle. Older (24-wk-old) pair-fed cp/cp rats had significantly reduced plasma triglyceride levels, improved micro- and macrovascular function, and reduced severity of ischemic myocardial lesions. These changes indicate a significant amelioration of end-stage disease processes in this animal model and the complexity of metabolic/physiological responses in studies involving alterations in food intake. The effects illustrate the sensitivity of the JCR: LA-cp rat, an animal model for the metabolic syndrome and associated cardiovascular disease, to the environmental and experimental milieu. Similar stress-related mechanisms may play a role in metabolically induced cardiovascular disease in susceptible human beings.
C1 [Russell, James C.; Proctor, Spencer D.; Kelly, Sandra E.] Univ Alberta, Alberta Inst Human Nutr, Agr Forestry Ctr 4 10, Metab & Cardiovasc Dis Lab, Edmonton, AB T6G 2P5, Canada.
   [Brindley, David N.] Univ Alberta, Dept Biochem, Signal Transduct Res Grp, Edmonton, AB T6G 2P5, Canada.
C3 University of Alberta; University of Alberta
RP Russell, JC (corresponding author), Univ Alberta, Alberta Inst Human Nutr, Agr Forestry Ctr 4 10, Metab & Cardiovasc Dis Lab, Edmonton, AB T6G 2P5, Canada.
EM Jim.Russell@ualberta.ca
RI Proctor, Spencer/F-2774-2012
OI Proctor, Spencer/0000-0002-7597-5262
CR Absher PM, 1999, ATHEROSCLEROSIS, V143, P245, DOI 10.1016/S0021-9150(98)00295-0
   Absher PM, 1997, ATHEROSCLEROSIS, V131, P187, DOI 10.1016/S0021-9150(97)06104-2
   Atkinson LL, 2003, AM J PHYSIOL-ENDOC M, V284, pE923, DOI 10.1152/ajpendo.00360.2002
   Atkinson LL, 2002, DIABETES, V51, P1548, DOI 10.2337/diabetes.51.5.1548
   Báez-Ruiz A, 2005, AM J PHYSIOL-GASTR L, V289, pG1015, DOI 10.1152/ajpgi.00488.2004
   BJORNTORP P, 2001, OBES REV, V2, P79
   BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911
   BRINDLEY DN, 1992, BRIT J PHARMACOL, V105, P679, DOI 10.1111/j.1476-5381.1992.tb09038.x
   BRINDLEY DN, 1991, BIOCHIM BIOPHYS ACTA, V1085, P119, DOI 10.1016/0005-2760(91)90239-E
   BRINDLEY DN, 1989, CLIN SCI, V77, P453, DOI 10.1042/cs0770453
   CHAOULOFF F, 1989, AM J PHYSIOL, V256, pR435, DOI 10.1152/ajpregu.1989.256.2.R435
   Chinen I, 2007, ENDOCRINOLOGY, V148, P160, DOI 10.1210/en.2006-1132
   Chua SC, 1996, DIABETES, V45, P1141, DOI 10.2337/diabetes.45.8.1141
   CLARKE SD, 1977, J NUTR, V107, P1277, DOI 10.1093/jn/107.7.1277
   DELEAN A, 1978, AM J PHYSIOL, V235, pE97, DOI 10.1152/ajpendo.1978.235.2.E97
   Despres JP, 1996, NEW ENGL J MED, V334, P952, DOI 10.1056/NEJM199604113341504
   Elam MB, 2001, J LIPID RES, V42, P2039
   Ide T, 2000, METABOLISM, V49, P521, DOI 10.1016/S0026-0495(00)80019-0
   Iso H, 2002, CIRCULATION, V106, P1229, DOI 10.1161/01.CIR.0000028145.58654.41
   Levine HJ, 1997, J AM COLL CARDIOL, V30, P1104
   Leza JC, 1998, J PHARMACOL EXP THER, V286, P1397
   Makino S, 2000, J NEUROENDOCRINOL, V12, P387
   MALABU UH, 1994, DIABETES, V43, P9, DOI 10.2337/diabetes.43.1.9
   Marshall SM, 2006, BMJ-BRIT MED J, V333, P475, DOI 10.1136/bmj.38922.650521.80
   Mattson MP, 2005, J NUTR BIOCHEM, V16, P129, DOI 10.1016/j.jnutbio.2004.12.007
   McArthur MD, 1998, METABOLISM, V47, P1383, DOI 10.1016/S0026-0495(98)90310-9
   OBrien SF, 1997, ENDOCRINOL METAB, V4, P155
   OZELCI A, 1977, J NUTR, V107, P1768, DOI 10.1093/jn/107.10.1768
   Pickavance LC, 2007, DIABETES OBES METAB, V9, P114, DOI 10.1111/j.1463-1326.2006.00586.x
   Proctor SD, 2004, ARTERIOSCL THROM VAS, V24, P2162, DOI 10.1161/01.ATV.0000143859.75035.5a
   Proctor SD, 2005, DIABETOLOGIA, V48, P1925, DOI 10.1007/s00125-005-1862-8
   Radomski MW, 1995, ATHEROSCLEROSIS, V118, pS69
   Richardson M, 1998, ATHEROSCLEROSIS, V138, P135, DOI 10.1016/S0021-9150(98)00012-4
   Rupp H, 1997, AM J PHYSIOL-REG I, V272, pR776, DOI 10.1152/ajpregu.1997.272.3.R776
   Russell JC, 2007, BRIT J PHARMACOL, V151, P216, DOI 10.1038/sj.bjp.0707226
   Russell JC, 2006, CARDIOVASC PATHOL, V15, P318, DOI 10.1016/j.carpath.2006.09.001
   RUSSELL JC, 1989, ARTERIOSCLEROSIS, V9, P869, DOI 10.1161/01.ATV.9.6.869
   Russell JC, 2005, J CARDIOVASC PHARM, V46, P746, DOI 10.1097/01.fjc.0000185785.85143.12
   Russell JC, 1996, CAN J PHYSIOL PHARM, V74, P879, DOI 10.1139/cjpp-74-8-879
   RUSSELL JC, 1994, METABOLISM, V43, P538, DOI 10.1016/0026-0495(94)90192-9
   Russell JC, 1998, DIABETES, V47, P770, DOI 10.2337/diabetes.47.5.770
   Russell JC, 2004, J CARDIOVASC PHARM, V44, P258, DOI 10.1097/00005344-200408000-00016
   Russell JC, 1998, DIABETOLOGIA, V41, P380, DOI 10.1007/s001250050920
   RUSSELL JC, 1995, ARTERIOSCL THROM VAS, V15, P918, DOI 10.1161/01.ATV.15.7.918
   Russell JC, 1998, MOL CELL BIOCHEM, V188, P113, DOI 10.1023/A:1006828724405
   Russell JC, 1999, METABOLISM, V48, P701, DOI 10.1016/S0026-0495(99)90168-3
   Russell JC, 2001, J CARDIOVASC PHARM, V37, P119, DOI 10.1097/00005344-200101000-00014
   Satoh Y, 2006, AM J PHYSIOL-REG I, V290, pR1276, DOI 10.1152/ajpregu.00775.2005
   VANCE JE, 1990, J LIPID RES, V31, P1491
   Vine DF, 2007, ATHEROSCLEROSIS, V190, P282, DOI 10.1016/j.atherosclerosis.2006.03.013
   Walder K, 1997, J ENDOCRINOL, V155, pR5, DOI 10.1677/joe.0.155R005
   Wan RQ, 2004, AM J PHYSIOL-HEART C, V287, pH1186, DOI 10.1152/ajpheart.00932.2003
   WILLIAMS G, 1992, PEPTIDES, V13, P537, DOI 10.1016/0196-9781(92)90085-H
   WuPeng XS, 1997, DIABETES, V46, P513, DOI 10.2337/diabetes.46.3.513
   Zanchi A, 2007, AM J PHYSIOL-ENDOC M, V293, pE91, DOI 10.1152/ajpendo.00024.2007
NR 55
TC 14
Z9 20
U1 0
U2 1
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD JUN
PY 2008
VL 294
IS 6
BP E1078
EP E1087
DI 10.1152/ajpendo.90257.2008
PG 10
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 309OD
UT WOS:000256469200009
PM 18413677
DA 2025-06-11
ER

PT J
AU Feng, XJ
   Yu, W
   Li, XD
   Zhou, FF
   Zhang, WL
   Shen, Q
   Li, JX
   Zhang, C
   Shen, PP
AF Feng, Xiujing
   Yu, Wen
   Li, Xinda
   Zhou, Feifei
   Zhang, Wenlong
   Shen, Qi
   Li, Jianxin
   Zhang, Can
   Shen, Pingping
TI Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by
   regulating hepatocyte lipid metabolism and oxidative stress via Nrf2
   activation
SO BIOCHEMICAL PHARMACOLOGY
LA English
DT Article
DE Apigenin; NAFLD; Nrf2; PPAR gamma
ID NONALCOHOLIC FATTY LIVER; DIET-INDUCED OBESITY; GENE-EXPRESSION; HEPATIC
   STEATOSIS; RECEPTOR-GAMMA; IN-VITRO; DISEASE; MICE; STEATOHEPATITIS;
   INJURY
AB Lipid metabolic disorders and oxidative stress in the liver are key steps in the progression of nonalcoholic fatty liver disease (NAFLD), which is a major risk factor for the development of metabolic syndrome. To date, no pharmacological treatment for this condition has been approved. Our previous study has found that the food-derived compound apigenin (Api) significantly attenuates obesity induced metabolic syndrome by acting as a peroxisome proliferator-activated receptor gamma modulator (PPARM). Herein, a high fat diet (HFD) induced NAFLD model was used to dig out whether Api had the effect on NAFLD. The results showed that Api had obvious effect in restraining NAFLD progression, including attenuating HFD induced lipid accumulation and oxidative stress in vivo. As a PPARM, although Api did significantly inhibit the expression of PPAR gamma target genes encoding the protein associated with lipid metabolism, it had no obvious activating effect on PPAR gamma. Interestingly, we found that Api promoted Nrf2 into the nucleus, thereby markedly activating Nrf2 to inhibit the lipid metabolism related genes and increase the oxidative stress related genes. Further Nrf2 knockdown/knockout and overexpression experiments showed that Api regulating PPAR gamma target genes was dependent on Nrf2 activation and the activation of Nrf2 counteracted the activation effect of PPAR gamma by Api. Importantly, we also found that Api might bind with Nrf2 via auto dock and ITC assay. Therefore, our results indicate that Api ameliorates NAFLD by a novel regulating mode of Nrf2 and PPAR gamma in inhibiting lipid metabolism and oxidative stress abnormity. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Feng, Xiujing; Yu, Wen; Li, Xinda; Zhou, Feifei; Zhang, Wenlong; Shen, Pingping] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Model Anim Res Ctr, Nanjing 210023, Jiangsu, Peoples R China.
   [Feng, Xiujing; Yu, Wen; Li, Xinda; Zhou, Feifei; Zhang, Wenlong; Shen, Pingping] Nanjing Univ, MOE Key Lab Model Anim Dis Study, Model Anim Res Ctr, Nanjing 210023, Jiangsu, Peoples R China.
   [Shen, Qi; Li, Jianxin] Nanjing Univ, Sch Chem & Chem Engn, Key Lab Analyt Chem Life Sci, Nanjing 210023, Jiangsu, Peoples R China.
   [Zhang, Can] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China.
   [Zhang, Can] China Pharmaceut Univ, Ctr Drug Discovery, State Key Lab Nat Med, Nanjing 210009, Peoples R China.
C3 Nanjing University; Nanjing University; Nanjing University; Nanjing
   University; China Pharmaceutical University
RP Shen, PP (corresponding author), Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Model Anim Res Ctr, Nanjing 210023, Jiangsu, Peoples R China.; Zhang, C (corresponding author), Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China.; Zhang, C (corresponding author), China Pharmaceut Univ, Ctr Drug Discovery, State Key Lab Nat Med, Nanjing 210009, Peoples R China.
EM zhangcan@cpu.edu.cn; ppshen@nju.edu.cn
RI Shen, PP/S-1616-2016; li, jianxin/CAF-6178-2022; Zhang,
   Can/JUU-9511-2023; Feng, Xiujing/HII-9555-2022
OI Feng, Xiujing/0000-0002-8887-3302
FU open fund of State Key Laboratory of Pharmaceutical Biotechnology,
   Nanjing University, China [KFGN-201501]; National Natural Science
   Foundation of China [81503082, 81673439, 81473220]; Natural Science
   Foundation of Jiangsu Province of China [BK20150575]; Postdoctoral
   Science Foundation of China [2015M570437]
FX The work was supported by the open fund of State Key Laboratory of
   Pharmaceutical Biotechnology, Nanjing University, China (Grant No.
   KFGN-201501), and the National Natural Science Foundation of China (Nos.
   81503082, 81673439 and 81473220), and the Natural Science Foundation of
   Jiangsu Province of China (No. BK20150575), and Postdoctoral Science
   Foundation of China (No. 2015M570437).
CR Abdelmegeed MA, 2011, J NUTR, V141, P603, DOI 10.3945/jn.110.135210
   Ahmed A, 2015, CLIN GASTROENTEROL H, V13, P2062, DOI 10.1016/j.cgh.2015.07.029
   Almeda-Valdés P, 2009, ANN HEPATOL, V8, pS18, DOI 10.1016/S1665-2681(19)31822-8
   [Anonymous], CRIT REV FOOD SCI NU
   [Anonymous], 2015, NAT REV DIS PRIMERS, V1, P15081
   Arango D, 2013, P NATL ACAD SCI USA, V110, pE2153, DOI 10.1073/pnas.1303726110
   Assini JM, 2013, CURR OPIN LIPIDOL, V24, P34, DOI 10.1097/MOL.0b013e32835c07fd
   Buwa CC, 2016, CARDIOVASC TOXICOL, V16, P286, DOI 10.1007/s12012-015-9336-9
   Cho HY, 2010, AM J RESP CRIT CARE, V182, P170, DOI 10.1164/rccm.200907-1047OC
   Colombo G., 2015, J CHROMATOGR B
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   Du J., 2016, ENDOCRINE
   Feldstein AE, 2004, HEPATOLOGY, V40, P185, DOI 10.1002/hep.20283
   Feng X., 2012, CLIN PHARM THOR, V92, P340
   Feng XJ, 2016, EBIOMEDICINE, V9, P61, DOI 10.1016/j.ebiom.2016.06.017
   Galli A, 2002, GASTROENTEROLOGY, V122, P1924, DOI 10.1053/gast.2002.33666
   García-Ruiz I, 2007, HEPATOLOGY, V46, P414, DOI 10.1002/hep.21687
   Gavrilova O, 2003, J BIOL CHEM, V278, P34268, DOI 10.1074/jbc.M300043200
   Gupte AA, 2010, HEPATOLOGY, V52, P2001, DOI 10.1002/hep.23941
   Hatia S, 2014, FREE RADICAL RES, V48, P387, DOI 10.3109/10715762.2013.879985
   Ikeda Y, 2000, J BIOL CHEM, V275, P33142, DOI 10.1074/jbc.M002319200
   Itoh K, 2010, ANTIOXID REDOX SIGN, V13, P1665, DOI 10.1089/ars.2010.3222
   Karlas T, 2013, BEST PRACT RES CL EN, V27, P195, DOI 10.1016/j.beem.2013.02.002
   Kirpich IA, 2011, J NUTR BIOCHEM, V22, P38, DOI 10.1016/j.jnutbio.2009.11.009
   Kitteringham NR, 2010, J PROTEOMICS, V73, P1612, DOI 10.1016/j.jprot.2010.03.018
   Lamlé J, 2008, GASTROENTEROLOGY, V134, P1159, DOI 10.1053/j.gastro.2008.01.011
   LEHMANN JM, 1995, J BIOL CHEM, V270, P12953, DOI 10.1074/jbc.270.22.12953
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   Machado MV, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0127991
   Marchesini G, 2003, HEPATOLOGY, V37, P917, DOI 10.1053/jhep.2003.50161
   Mokdad AH, 2003, JAMA-J AM MED ASSOC, V289, P76, DOI 10.1001/jama.289.1.76
   Morán-Salvador E, 2011, FASEB J, V25, P2538, DOI 10.1096/fj.10-173716
   Mueller M, 2008, J AGR FOOD CHEM, V56, P11621, DOI 10.1021/jf802298w
   Panda S, 2007, J PHARM PHARMACOL, V59, P1543, DOI 10.1211/jpp.59.11.0012
   Paredes-Gonzalez X, 2015, BIOPHARM DRUG DISPOS, V36, P440, DOI 10.1002/bdd.1956
   Paredes-Gonzalez X, 2014, AAPS J, V16, P727, DOI 10.1208/s12248-014-9613-8
   Peyrou M, 2012, PPAR RES, V2012, DOI 10.1155/2012/757803
   Pi JB, 2010, J BIOL CHEM, V285, P9292, DOI 10.1074/jbc.M109.093955
   Rinella ME, 2015, JAMA-J AM MED ASSOC, V313, P2263, DOI 10.1001/jama.2015.5370
   Salam NK, 2008, CHEM BIOL DRUG DES, V71, P57, DOI 10.1111/j.1747-0285.2007.00606.x
   Shalem O, 2014, SCIENCE, V343, P84, DOI 10.1126/science.1247005
   Shi DM, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-173
   Shin S, 2009, EUR J PHARMACOL, V620, P138, DOI 10.1016/j.ejphar.2009.08.022
   Smith BW, 2011, NAT REV ENDOCRINOL, V7, P456, DOI 10.1038/nrendo.2011.72
   Tailleux A, 2012, BBA-MOL CELL BIOL L, V1821, P809, DOI 10.1016/j.bbalip.2011.10.016
   Tanaka Y, 2008, J PHARMACOL EXP THER, V325, P655, DOI 10.1124/jpet.107.135822
   Tong X, 2013, ANTI-CANCER AGENT ME, V13, P971, DOI 10.2174/18715206113139990119
   Yamazaki T, 2011, J NUTR BIOCHEM, V22, P543, DOI 10.1016/j.jnutbio.2010.04.009
   Yan C., 2016, MOL NUTR FOOD RES
   Yang L, 2010, INFLAMM RES, V59, P1061, DOI 10.1007/s00011-010-0226-0
   Yang YM, 2012, HEPATOLOGY, V56, P2209, DOI 10.1002/hep.25912
   Yu ST, 2003, J BIOL CHEM, V278, P498, DOI 10.1074/jbc.M210062200
   Zhai XH, 2013, MOL NUTR FOOD RES, V57, P249, DOI 10.1002/mnfr.201200536
   Zhang S, 2013, FOOD CHEM, V141, P2108, DOI 10.1016/j.foodchem.2013.05.019
   Zhang YKJ, 2010, TOXICOL APPL PHARM, V245, P326, DOI 10.1016/j.taap.2010.03.016
NR 55
TC 179
Z9 186
U1 7
U2 124
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0006-2952
EI 1873-2968
J9 BIOCHEM PHARMACOL
JI Biochem. Pharmacol.
PD JUL 15
PY 2017
VL 136
BP 136
EP 149
DI 10.1016/j.bcp.2017.04.014
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EX3KB
UT WOS:000403129900013
PM 28414138
DA 2025-06-11
ER

PT J
AU Amos, D
   Cook, C
   Santanam, N
AF Amos, Deborah
   Cook, Carla
   Santanam, Nalini
TI Omega 3 rich diet modulates energy metabolism via GPR120-Nrf2 crosstalk
   in a novel antioxidant mouse model
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
LA English
DT Article
DE Diet-induced obesity; Redox stress; Adipose tissue; Catalase
ID HIGH-FAT DIET; GROWTH-FACTOR 21; ADIPOSE-TISSUE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; EICOSAPENTAENOIC ACID; REDUCTIVE STRESS; SUBSTRATE
   OXIDATION; KEAP1-NRF2 SYSTEM; INDUCED OBESITY
AB With obesity rates reaching epidemic proportions, more studies concentrated on reducing the risk and treating this epidemic are vital. Redox stress is an important metabolic regulator involved in the pathophysiology of cardiovascular disease, Type 2 diabetes, and obesity. Oxygen and nitrogen-derived free radicals alter glucose and lipid homeostasis in key metabolic tissues, leading to increases in risk of developing metabolic syndrome. Oxidants derived from dietary fat differ in their metabolic regulation, with numerous studies showing benefits from a high omega 3 rich diet compared to the frequently consumed "western diet" rich in saturated fat. Omega 3 (OM3) fatty acids improve lipid profile, lower inflammation, and ameliorate insulin resistance, possibly through maintaining redox homeostasis. This study is based on the hypothesis that altering endogenous antioxidant production and/or increasing OM3 rich diet consumption will improve energy metabolism and maintain insulin sensitivity. We tested the comparative metabolic effects of a diet rich in saturated fat (HFD) and an omega 3-enriched diet (OM3) in the newly developed 'stress-less' mice model that overexpresses the endogenous antioxidant catalase. Eight weeks of dietary intervention showed that mice overexpressing endogenous catalase compared to their wild-type controls when fed an OM3 enriched diet, in contrast to HFD, activated GPR120-Nrf2 cross-talk to maintain balanced energy metabolism, normal circadian rhythm, and insulin sensitivity. These findings suggest that redox regulation of GPR120/FFAR4 might be an important target in reducing risk of metabolic syndrome and associated diseases.
C1 [Amos, Deborah; Cook, Carla; Santanam, Nalini] Marshall Univ, Joan C Edwards Sch Med, Dept Biomed Sci, 1700 3rd Ave,435S BBSC, Huntington, WV 25755 USA.
C3 Marshall University
RP Santanam, N (corresponding author), Marshall Univ, Joan C Edwards Sch Med, Dept Biomed Sci, 1700 3rd Ave,435S BBSC, Huntington, WV 25755 USA.
EM santanam@marshall.edu
OI Santanam, Nalini/0000-0003-3343-6081
FU NIH [5R01HL-074239, 5P20RR016477, 1R15AG051062-01]; WV-NASA Grant
   Consortium
FX The authors acknowledge Dr. Jung Han Kim for her assistance with
   ECHO-MRI and CLAMS studies as well as Logan Efaw, Melissa Massie, Aaron
   Roberts, Jonique George and Sarah Marshall for their assistance with the
   feeding studies, quantitative PCR and Western Blotting. This study was
   partially supported by NIH Grant 5R01HL-074239 (NS), 5P20RR016477 (NS),
   1R15AG051062-01 (NS), and WV-NASA Grant Consortium (DA).
CR Abbott KA, 2016, BRIT J NUTR, V115, P1379, DOI 10.1017/S0007114516000258
   AEBI H, 1984, METHOD ENZYMOL, V105, P121
   Albarado DC, 2004, ENDOCRINOLOGY, V145, P243, DOI 10.1210/en.2003-0452
   ALBERTI KGMM, 1975, LANCET, V1, P1307
   Albracht-Schulte K, 2018, J NUTR BIOCHEM, V58, P1, DOI 10.1016/j.jnutbio.2018.02.012
   Amos DL, 2017, BBA-MOL BASIS DIS, V1863, P2293, DOI 10.1016/j.bbadis.2017.06.016
   Gómez-Sámano MA, 2017, REDOX BIOL, V11, P335, DOI 10.1016/j.redox.2016.12.024
   Antunes LC, 2016, ARCH ENDOCRIN METAB, V60, P138, DOI 10.1590/2359-3997000000169
   Barazzoni R, 2018, EAT WEIGHT DISORD-ST, V23, P149, DOI 10.1007/s40519-018-0481-6
   BEYLOT M, 1988, DIABETES METAB, V14, P20
   Branecky KL, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0137970
   Brewer AC, 2013, ANTIOXID REDOX SIGN, V18, P1114, DOI 10.1089/ars.2012.4914
   Cacho J, 2008, AM J PHYSIOL-ENDOC M, V295, pE1269, DOI 10.1152/ajpendo.90207.2008
   Carrier A, 2017, ANTIOXID REDOX SIGN, V26, P429, DOI 10.1089/ars.2016.6929
   Carstens MT, 2013, NUTR METAB, V10, DOI 10.1186/1743-7075-10-8
   Chartoumpekis DV, 2011, DIABETES, V60, P2465, DOI 10.2337/db11-0112
   Chen J, 2014, DIABETES METAB J, V38, P337, DOI 10.4093/dmj.2014.38.5.337
   Chen VP, 2016, ENDOCRINOLOGY, V157, P3086, DOI 10.1210/en.2016-1166
   Chen XL, 2004, ARCH BIOCHEM BIOPHYS, V422, P197, DOI 10.1016/j.abb.2003.12.023
   Chen XL, 2003, MECH AGEING DEV, V124, P219, DOI 10.1016/S0047-6374(02)00161-6
   Choe SS, 2016, FRONT ENDOCRINOL, V7, DOI 10.3389/fendo.2016.00030
   Chopra M., 2014, American Journal of Food and Nutrition, V2, P66, DOI DOI 10.12691/AJFN-2-4-4
   Church C, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000599
   Cipollina C, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/501792
   Drummond GR, 2011, NAT REV DRUG DISCOV, V10, P453, DOI 10.1038/nrd3403
   Eicher-Miller HA, 2017, NUTRIENTS, V9, DOI 10.3390/nu9010086
   Fedorova M, 2014, MASS SPECTROM REV, V33, P79, DOI 10.1002/mas.21381
   Figueroa AL, 2016, CIRC-CARDIOVASC IMAG, V9, DOI 10.1161/CIRCIMAGING.115.004043
   Forbes S, 2006, EUR J ENDOCRINOL, V155, P469, DOI 10.1530/eje.1.02240
   Furusawa Y, 2014, GENES CELLS, V19, P864, DOI 10.1111/gtc.12186
   Gao L, 2007, J BIOL CHEM, V282, P2529, DOI 10.1074/jbc.M607622200
   Ge X, 2015, PATHOBIOL AGING AGE, V5, DOI 10.3402/pba.v5.28776
   Ghantous CM, 2015, INT J ENDOCRINOL, V2015, DOI 10.1155/2015/534320
   Goss AM, 2013, OBESITY, V21, P1133, DOI 10.1002/oby.20191
   Haidara M, 2011, CURR PHARM DESIGN, V17, P3699, DOI 10.2174/138161211798220882
   Han CY, 2010, DIABETES, V59, P386, DOI 10.2337/db09-0925
   Hatori M, 2012, CELL METAB, V15, P848, DOI 10.1016/j.cmet.2012.04.019
   Heit C, 2017, FREE RADICAL BIO MED, V103, P48, DOI 10.1016/j.freeradbiomed.2016.12.011
   Heydemann A, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/2902351
   Hirabara SM, 2013, J NUTR BIOCHEM, V24, P1136, DOI 10.1016/j.jnutbio.2012.08.014
   Hui XY, 2016, J MOL CELL BIOL, V8, P110, DOI 10.1093/jmcb/mjw013
   Ichimura A, 2014, FRONT PHARMACOL, V5, DOI 10.3389/fphar.2014.00236
   Ichimura A, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00111
   Ichimura A, 2012, NATURE, V483, P350, DOI 10.1038/nature10798
   Ide K, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0706-8
   Imamura Takeshi, 2010, Nihon Yakurigaku Zasshi, V136, P359
   Itoh M, 2007, ARTERIOSCL THROM VAS, V27, P1918, DOI 10.1161/ATVBAHA.106.136853
   Jackson SJ, 2017, LAB ANIM-UK, V51, P160, DOI 10.1177/0023677216653984
   Jung CH, 2017, KOREAN J INTERN MED, V32, P611, DOI 10.3904/kjim.2016.259
   Jung UJ, 2014, INT J MOL SCI, V15, P6184, DOI 10.3390/ijms15046184
   Kern PA, 2003, DIABETES, V52, P1779, DOI 10.2337/diabetes.52.7.1779
   Korge P, 2015, BBA-BIOENERGETICS, V1847, P514, DOI 10.1016/j.bbabio.2015.02.012
   Lawler HM, 2016, J CLIN ENDOCR METAB, V101, P1422, DOI 10.1210/jc.2015-4125
   Lee MY, 2008, YONSEI MED J, V49, P901, DOI 10.3349/ymj.2008.49.6.901
   Lee SE, 2015, J CARDIOVASC PHARM, V66, P108, DOI 10.1097/FJC.0000000000000251
   LEIBEL RL, 1995, NEW ENGL J MED, V332, P621, DOI 10.1056/NEJM199503093321001
   Lengyel E, 2018, TRENDS CANCER, V4, P374, DOI 10.1016/j.trecan.2018.03.004
   Lin XL, 2017, BIOMED REP, V6, P495, DOI 10.3892/br.2017.890
   Lin ZF, 2013, CELL METAB, V17, P779, DOI 10.1016/j.cmet.2013.04.005
   Lipinski B, 2002, BRIT J NUTR, V87, P93, DOI 10.1079/BJN2001435
   Liu Q, 2014, MAR DRUGS, V12, P2341, DOI 10.3390/md12052341
   Bargut TCL, 2016, EUR J NUTR, V55, P159, DOI 10.1007/s00394-015-0834-0
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   Luna-Luna M, 2015, ARCH MED RES, V46, P392, DOI 10.1016/j.arcmed.2015.05.007
   Luo XQ, 2016, MOL NUTR FOOD RES, V60, P871, DOI 10.1002/mnfr.201500714
   Mahendran Y, 2013, DIABETES, V62, P3618, DOI 10.2337/db12-1363
   Marseglia L, 2015, INT J MOL SCI, V16, P378, DOI 10.3390/ijms16010378
   Marvyn PM, 2016, DATA BRIEF, V7, P472, DOI 10.1016/j.dib.2016.02.066
   Matzinger M, 2018, BIOTECHNOL ADV, V36, P1738, DOI 10.1016/j.biotechadv.2017.12.015
   McArdle Maeve A, 2013, Front Endocrinol (Lausanne), V4, P52, DOI 10.3389/fendo.2013.00052
   McMurray F, 2016, OBESITY, V24, P2301, DOI 10.1002/oby.21654
   Meidenbauer JJ, 2014, NUTR METAB, V11, DOI 10.1186/1743-7075-11-23
   Meilhac O, 2000, J LIPID RES, V41, P1205
   Meilhac O, 2001, ARTERIOSCL THROM VAS, V21, P1681, DOI 10.1161/hq1001.097106
   Meissner M, 2010, MED SCI SPORT EXER, V42, P1460, DOI 10.1249/MSS.0b013e3181cfcb02
   Miyamoto J, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17040450
   Muzumdar R, 2008, AGING CELL, V7, P438, DOI 10.1111/j.1474-9726.2008.00391.x
   Nanthirudjanar T, 2013, LIPIDS HEALTH DIS, V12, DOI 10.1186/1476-511X-12-73
   Newman JC, 2014, TRENDS ENDOCRIN MET, V25, P42, DOI 10.1016/j.tem.2013.09.002
   Nilsson J, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0132-8
   NISHINA PM, 1994, METABOLISM, V43, P549, DOI 10.1016/0026-0495(94)90194-5
   Oh DY, 2014, NAT MED, V20, P942, DOI 10.1038/nm.3614
   Oh DY, 2012, CELL METAB, V15, P564, DOI 10.1016/j.cmet.2012.04.009
   Oh DY, 2010, CELL, V142, P687, DOI 10.1016/j.cell.2010.07.041
   Oliveira V, 2015, ENDOCRINOLOGY, V156, P4033, DOI 10.1210/en.2014-1880
   Pærregaard SI, 2016, MEDIAT INFLAMM, V2016, DOI 10.1155/2016/1536047
   Pall Martin L., 2015, Shengli Xuebao, V67, P1
   Palmer BF, 2015, MOL CELL ENDOCRINOL, V402, P113, DOI 10.1016/j.mce.2014.11.029
   Paniagua JA, 2016, WORLD J DIABETES, V7, P483, DOI 10.4239/wjd.v7.i19.483
   Paoli A, 2013, EUR J CLIN NUTR, V67, P789, DOI 10.1038/ejcn.2013.116
   Parastatidis I, 2013, ARTERIOSCL THROM VAS, V33, P2389, DOI 10.1161/ATVBAHA.113.302175
   Park YS, 2016, MEDIAT INFLAMM, V2016, DOI 10.1155/2016/8675905
   Patel B, 2018, FREE RADICAL BIO MED, V122, P150, DOI 10.1016/j.freeradbiomed.2018.02.004
   Pendergast JS, 2013, EUR J NEUROSCI, V37, P1350, DOI 10.1111/ejn.12133
   PERONNET F, 1991, CAN J SPORT SCI, V16, P23
   Pfaffl MW, 2001, NUCLEIC ACIDS RES, V29, DOI 10.1093/nar/29.9.e45
   Puchalska P, 2017, CELL METAB, V25, P262, DOI 10.1016/j.cmet.2016.12.022
   Quesada-Lopez T, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms13479
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   Rochette L, 2014, BBA-GEN SUBJECTS, V1840, P2709, DOI 10.1016/j.bbagen.2014.05.017
   Ruan Y, 2015, INT J DIABETES DEV C, V35, pS471, DOI 10.1007/s13410-014-0201-3
   Saini RK, 2018, LIFE SCI, V203, P255, DOI 10.1016/j.lfs.2018.04.049
   Jiménez-Osorio AS, 2015, CLIN CHIM ACTA, V448, P182, DOI 10.1016/j.cca.2015.07.009
   Sasaki T, 2017, NUTRIENTS, V9, DOI 10.3390/nu9101151
   Schlein C, 2016, CELL METAB, V23, P441, DOI 10.1016/j.cmet.2016.01.006
   Schriner SE, 2006, AGE, V28, P209, DOI 10.1007/s11357-006-9010-z
   Seo HA, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/184598
   Shahidi F, 2018, ANNU REV FOOD SCI T, V9, P345, DOI 10.1146/annurev-food-111317-095850
   Sheng X, 2018, HORM METAB RES, V50, P397, DOI 10.1055/a-0603-7899
   Silva-Palacios A, 2016, AGEING RES REV, V26, P81, DOI 10.1016/j.arr.2015.12.005
   Silver DL, 1999, J BIOL CHEM, V274, P4140, DOI 10.1074/jbc.274.7.4140
   Smith KB, 2016, PRIMARY CARE, V43, P121, DOI 10.1016/j.pop.2015.10.001
   Snel M, 2012, INT J ENDOCRINOL, V2012, DOI 10.1155/2012/983814
   So M, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-99
   Sundström L, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0189060
   Tanajak P, 2018, DIABETES VASC DIS RE, V15, P263, DOI 10.1177/1479164118757152
   Tani S, 2019, HEART VESSELS, V34, P189, DOI 10.1007/s00380-018-1226-1
   Tarantini S, 2018, J GERONTOL A-BIOL, V73, P853, DOI 10.1093/gerona/glx177
   Teodoro JS, 2013, TOXICOL MECH METHOD, V23, P297, DOI 10.3109/15376516.2012.759305
   Tzanetakou IP, 2012, AGEING RES REV, V11, P220, DOI 10.1016/j.arr.2011.12.003
   Umanskaya A, 2014, P NATL ACAD SCI USA, V111, P15250, DOI 10.1073/pnas.1412754111
   Uruno A, 2015, ARCH BIOCHEM BIOPHYS, V566, P76, DOI 10.1016/j.abb.2014.12.012
   Valenzuela R, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046400
   Walker CG, 2014, BRIT J NUTR, V111, P679, DOI 10.1017/S0007114513002985
   Wang XW, 2011, J CLIN ENDOCR METAB, V96, P885, DOI 10.1210/jc.2010-2061
   Weiss EP, 2017, MED SCI SPORT EXER, V49, P206, DOI 10.1249/MSS.0000000000001074
   Williamson JR, 1999, DIABETES RES CLIN PR, V45, P81
   Wu LY, 2014, METABOLISM, V63, P1469, DOI 10.1016/j.metabol.2014.08.010
   Yamada H, 2017, NUTR METAB, V14, DOI 10.1186/s12986-017-0188-0
   Yamamoto M, 2018, PHYSIOL REV, V98, P1169, DOI 10.1152/physrev.00023.2017
   Yan LJ, 2014, J DIABETES RES, V2014, DOI 10.1155/2014/137919
   Yan P, 1983, Ann Acad Med Singap, V12, P596
   Yoon M, 2002, EXP MOL MED, V34, P481, DOI 10.1038/emm.2002.67
   Yu YH, 2016, INT IMMUNOPHARMACOL, V38, P144, DOI 10.1016/j.intimp.2016.05.026
   Zgorzynska E, 2017, PHARMACOL REP, V69, P935, DOI 10.1016/j.pharep.2017.04.009
   Zhang L, 2016, AM J TRANSL RES, V8, P5309
   Zhang X, 2008, DIABETES, V57, P1246, DOI 10.2337/db07-1476
   Zhou BD, 2017, LIPIDS HEALTH DIS, V16, DOI [10.1186/s12944-016-0388-z, 10.1186/s12944-017-0572-9]
   Zhu H, 2008, EXP BIOL MED, V233, P463, DOI 10.3181/0711-RM-304
NR 139
TC 23
Z9 26
U1 0
U2 23
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1388-1981
EI 1879-2618
J9 BBA-MOL CELL BIOL L
JI Biochim. Biophys. Acta Mol. Cell Biol. Lipids
PD APR
PY 2019
VL 1864
IS 4
BP 466
EP 488
DI 10.1016/j.bbalip.2019.01.002
PG 23
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA HM3IF
UT WOS:000459366300003
PM 30658097
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Devaraj, S
   Leonard, S
   Traber, MG
   Jialal, I
AF Devaraj, Sridevi
   Leonard, Scott
   Traber, Maret G.
   Jialal, Ishwarlal
TI γ-tocopherol supplementation alone and in combination with α-tocopherol
   alters biomarkers of oxidative stress and inflammation in subjects with
   metabolic syndrome
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE antioxidant; tocopherol; inflammation; oxidative stress; nitrative
   stress
ID C-REACTIVE PROTEIN; VITAMIN-E; PLATELET-AGGREGATION; NITRIC-OXIDE;
   DISEASE; MARKERS; HUMANS
AB Metabolic syndrome (MetS) is associated with increased incidence of diabetes and cardiovascular disease (CVD). Prospective clinical trials with alpha-tocopherol (AT) have not yielded positive results. Because AT supplementation decreases circulating gamma-tocopherol (GT), we evaluated supplementation with GT (800 mg/day), AT (800 mg/day), the combination or placebo for 6 weeks alone AT and GT concentrations, biomarkers of oxidative stress, and inflammation in subjects with MetS (n = 20/group). Plasma AT and GT levels increased following supplementation with AT alone or GT alone or in combination. AT supplementation significantly decreased GT levels. Urinary alpha- and gamma-CEHC, metabolites of the respective Ts, also increased correspondingly, i.e., alpha-CEHC with AT and gamma-CEHC with GT supplementation, compared to placebo. HsCRP levels significantly decreased in the combined AT+GT group. LPS-activated whole blood release of IL-1 and IL-6 did not change. There was a significant decrease in TNF with AT alone or in combination with GT. Plasma MDA/HNE and lipid peroxides were significantly decreased with AT, GT, or in combination. Nitrotyrosine levels were significantly decreased only with GT or GT+AT but not with AT compared to placebo, Thus, the combination of AT and GT supplementation appears to be superior to either supplementation alone on biomarkers of oxidative stress and inflammation and needs to be tested in prospective clinical trials to elucidate its utility in CVD prevention. (C) 2007 Elsevier Inc. All rights reserved.
C1 [Devaraj, Sridevi; Jialal, Ishwarlal] UC Davis Med Ctr, Dept Pathol, Lab Atherosclerosis & Metab Res, Sacramento, CA 95817 USA.
   [Devaraj, Sridevi; Jialal, Ishwarlal] UC Davis Med Ctr, Lab Med, Sacramento, CA 95817 USA.
   [Leonard, Scott; Traber, Maret G.] Oregon State Univ, Linus Pauling Inst, Corvallis, OR 97331 USA.
C3 University of California System; University of California Davis;
   University of California System; University of California Davis; Oregon
   State University
RP Devaraj, S (corresponding author), UC Davis Med Ctr, Dept Pathol, Lab Atherosclerosis & Metab Res, 4635 2 Ave,Res 1 Bldg,Rm 3000, Sacramento, CA 95817 USA.
EM sridevi.devaraj@ucdmc.ucdavis.edu
RI Traber, Maret/ABI-2511-2020; Jialal, Ishwarlal/AAG-6218-2019
OI Leonard, Scott/0000-0001-9967-7078; Traber, Maret/0000-0002-2892-4024
CR COONEY RV, 1993, P NATL ACAD SCI USA, V90, P1771, DOI 10.1073/pnas.90.5.1771
   DEGROOT H, 1993, FEBS LETT, V315, P139, DOI 10.1016/0014-5793(93)81150-X
   Devaraj S, 2000, FREE RADICAL BIO MED, V29, P790, DOI 10.1016/S0891-5849(00)00420-2
   Devaraj S, 2005, NUTR REV, V63, P290, DOI 10.1111/j.1753-4887.2005.tb00143.x
   Devaraj S, 2003, AM J CLIN NUTR, V77, P530, DOI 10.1093/ajcn/77.3.530
   Devaraj S, 2006, AM J CLIN NUTR, V84, P756, DOI 10.1093/ajcn/84.4.756
   HANDELMAN GJ, 1985, J NUTR, V115, P807, DOI 10.1093/jn/115.6.807
   Hathcock JN, 2005, AM J CLIN NUTR, V81, P736, DOI 10.1093/ajcn/81.4.736
   Himmelfarb J, 2003, KIDNEY INT, V64, P978, DOI 10.1046/j.1523-1755.2003.00151.x
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jialal I, 2005, J NUTR, V135, P348, DOI 10.1093/jn/135.2.348
   Jialal I, 2004, HYPERTENSION, V44, P6, DOI 10.1161/01.HYP.0000130484.20501.df
   Jialal I, 2001, Am J Clin Pathol, V116 Suppl, pS108
   Jiang Q, 2001, AM J CLIN NUTR, V74, P714
   Jiang Q, 2000, P NATL ACAD SCI USA, V97, P11494, DOI 10.1073/pnas.200357097
   Leonard SW, 2005, J LIPID RES, V46, P1068, DOI 10.1194/jlr.D400044-JLR200
   Leonard SW, 2005, FREE RADICAL BIO MED, V38, P857, DOI 10.1016/j.freeradbiomed.2004.12.001
   Liu ML, 2003, AM J CLIN NUTR, V77, P700, DOI 10.1093/ajcn/77.3.700
   Lorenzo C, 2007, DIABETES CARE, V30, P8, DOI 10.2337/dc06-1414
   O'Byrne DJ, 2002, AM J CLIN NUTR, V76, P1367, DOI 10.1093/ajcn/76.6.1367
   Podda M, 1996, J LIPID RES, V37, P893
   REITER E, 2007, MOL ASPECTS MED
   Rubbo H, 2000, J BIOL CHEM, V275, P10812, DOI 10.1074/jbc.275.15.10812
   Saldeen T, 1999, J AM COLL CARDIOL, V34, P1208, DOI 10.1016/S0735-1097(99)00333-2
   Wagner KH, 2004, ANN NUTR METAB, V48, P169, DOI 10.1159/000079555
   Wu JHY, 2007, CLIN CHEM, V53, P511, DOI 10.1373/clinchem.2006.076992
NR 26
TC 163
Z9 182
U1 1
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD MAR 15
PY 2008
VL 44
IS 6
BP 1203
EP 1208
DI 10.1016/j.freeradbiomed.2007.12.018
PG 6
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 278HH
UT WOS:000254275300027
PM 18191645
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Gersch, C
   Palii, SP
   Imaram, W
   Kim, KM
   Karumanchi, SA
   Angerhofer, A
   Johnson, RJ
   Henderson, GN
AF Gersch, Christine
   Palii, Sergiu P.
   Imaram, Witcha
   Kim, Kyung Mee
   Karumanchi, S. Ananth
   Angerhofer, Alexander
   Johnson, Richard J.
   Henderson, George N.
TI Reactions of Peroxynitrite with Uric Acid: Formation of Reactive
   Intermediates, Alkylated Products and Triuret, and In Vivo Production of
   Triuret Under Conditions of Oxidative Stress
SO NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
LA English
DT Article
DE Uric acid; methyluric acid; peroxynitrite; cardiovascular disease;
   endothelial dysfunction; triuret; ascorbate; alkylation; preeclampsia;
   hypertension; oxidative stress; reactive intermediates
ID FREE-RADICAL FORMATION; NITRIC-OXIDE; BLOOD-PRESSURE; URATE OXIDASE;
   HYPERURICEMIA; ANTIOXIDANT; IDENTIFICATION; INACTIVATION; PATHOGENESIS;
   PROOXIDANT
AB Hyperuricemia is associated with hypertension, metabolic syndrome, preeclampsia, cardio-vascular disease and renal disease, all conditions associated with oxidative stress. We hypothesized that uric acid, a known antioxidant, might become prooxidative following its reaction with oxidants; and, thereby contribute to the pathogenesis of these diseases. Uric acid and 1,3-15N2-uric acid were reacted with peroxynitrite in different buffers and in the presence of alcohols, antioxidants and in human plasma. The reaction products were identified using liquid chromatography-mass spectrometry (LC-MS) analyses. The reactions generate reactive intermediates that yielded triuret as their final product. We also found that the antioxidant, ascorbate, could partially prevent this reaction. Whereas triuret was preferentially generated by the reactions in aqueous buffers, when uric acid or 1,3-15N2-uric acid was reacted with peroxynitrite in the presence of alcohols, it yielded alkylated alcohols as the final product. By extension, this reaction can alkylate other biomolecules containing OH groups and others containing labile hydrogens. Triuret was also found to be elevated in the urine of subjects with preeclampsia, a pregnancy-specific hypertensive syndrome that is associated with oxidative stress, whereas very little triuret is produced in normal healthy volunteers. We conclude that under conditions of oxidative stress, uric acid can form reactive intermediates, including potential alkylating species, by reacting with peroxynitrite. These reactive intermediates could possibly explain how uric acid contributes to the pathogenesis of diseases such as the metabolic syndrome and hypertension.
C1 [Palii, Sergiu P.; Kim, Kyung Mee; Henderson, George N.] Univ Florida, Coll Med, Dept Med, Div Endocrinol & Metab, Gainesville, FL 32610 USA.
   [Imaram, Witcha; Angerhofer, Alexander] Univ Florida, Dept Chem, Coll Liberal Arts & Sci, Gainesville, FL 32610 USA.
   [Karumanchi, S. Ananth] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA USA.
   [Johnson, Richard J.; Henderson, George N.] Univ Florida, Div Nephrol & Hypertens, Dept Med, Gainesville, FL 32610 USA.
   [Henderson, George N.] Univ Florida, Gen Clin Res Ctr, Gainesville, FL 32610 USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida; Harvard University;
   Harvard University Medical Affiliates; Beth Israel Deaconess Medical
   Center; Harvard Medical School; State University System of Florida;
   University of Florida; State University System of Florida; University of
   Florida
RP Henderson, GN (corresponding author), Univ Florida, Hlth Sci Ctr, Div Nephrol, Dept Med, Box 100224, Gainesville, FL 32610 USA.
EM hende3000@yahoo.com
RI ; Angerhofer, Alexander/E-3143-2010
OI Karumanchi, Subbian/0000-0002-2281-6831; Angerhofer,
   Alexander/0000-0002-8580-6024
FU NCRR NIH HHS [M01-RR00082, M01 RR000082] Funding Source: Medline; NHLBI
   NIH HHS [HL-68607, R01 HL068607] Funding Source: Medline; NIDDK NIH HHS
   [R01 DK052121, DK-52121] Funding Source: Medline
CR Agarwal A, 2005, REPROD BIOL ENDOCRIN, V3, DOI 10.1186/1477-7827-3-28
   Althaus JS, 1997, MICROCHEM J, V56, P155, DOI 10.1006/mchj.1996.1444
   AMES BN, 1981, P NATL ACAD SCI-BIOL, V78, P6858, DOI 10.1073/pnas.78.11.6858
   Angerhofer A, 2004, FREE RADICAL BIO MED, V37, pS14
   ARUOMA OI, 1989, FEBS LETT, V244, P76, DOI 10.1016/0014-5793(89)81166-4
   Bagnati M, 1999, BIOCHEM J, V340, P143, DOI 10.1042/0264-6021:3400143
   BILTZ H, 1916, LIEBIGS ANN CHEM, V413, P7
   Casanueva E, 2003, J NUTR, V133, p1700S, DOI 10.1093/jn/133.5.1700S
   Feig DI, 2003, HYPERTENSION, V42, P247, DOI 10.1161/01.HYP.0000085858.66548.59
   Feig DI, 2004, KIDNEY INT, V66, P281, DOI 10.1111/j.1523-1755.2004.00729.x
   GERSCH C, 2008, NUCLEOS NUCLEOT, P967
   Goldstein S, 2001, CHEM RES TOXICOL, V14, P657, DOI 10.1021/tx010066n
   Goldstein S, 2007, J AM CHEM SOC, V129, P10597, DOI 10.1021/ja073609+
   HICKS M, 1993, FREE RADICAL RES COM, V18, P337, DOI 10.3109/10715769309147501
   Hink HU, 2002, ARTERIOSCL THROM VAS, V22, P1402, DOI 10.1161/01.ATV.0000027524.86752.02
   Johnson RJ, 2005, HYPERTENSION, V45, P18, DOI 10.1161/01.HYP.0000150785.39055.e8
   Kahn K, 1997, J AM CHEM SOC, V119, P5435, DOI 10.1021/ja970375t
   Kanbay M, 2007, INT UROL NEPHROL, V39, P1227, DOI 10.1007/s11255-007-9253-3
   Kand'ár R, 2006, CLIN CHIM ACTA, V365, P249, DOI 10.1016/j.cca.2005.09.002
   Kang DH, 2002, J AM SOC NEPHROL, V13, P2888, DOI 10.1097/01.ASN.0000034910.58454.FD
   KITTRIDGE KJ, 1984, FEBS LETT, V170, P162, DOI 10.1016/0014-5793(84)81391-5
   Konen IM, 2005, J CHEM PHYS, V123, DOI 10.1063/1.2126968
   Krishnan E, 2007, HYPERTENSION, V49, P298, DOI 10.1161/01.HYP.0000254480.64564.b6
   Kuzkaya N, 2005, BIOCHEM PHARMACOL, V70, P343, DOI 10.1016/j.bcp.2005.05.009
   Kuzkaya N, 2003, J BIOL CHEM, V278, P22546, DOI 10.1074/jbc.M302227200
   Lesar A, 2006, J PHYS CHEM A, V110, P7898, DOI 10.1021/jp0614244
   Mak AM, 2007, J PHYS CHEM A, V111, P8202, DOI 10.1021/jp073142p
   MAPLES KR, 1988, J BIOL CHEM, V263, P1709
   Mazzali M, 2001, HYPERTENSION, V38, P1101, DOI 10.1161/hy1101.092839
   Mazzali M, 2002, AM J PHYSIOL-RENAL, V282, pF991, DOI 10.1152/ajprenal.00283.2001
   Meli R, 2002, J BIOL INORG CHEM, V7, P31, DOI 10.1007/s007750100262
   Merényi G, 1998, CHEM RES TOXICOL, V11, P243, DOI 10.1021/tx980026s
   Nakagawa T, 2005, NAT CLIN PRACT NEPHR, V1, P80, DOI 10.1038/ncpneph0019
   Nakagawa T, 2006, AM J PHYSIOL-RENAL, V290, pF625, DOI 10.1152/ajprenal.00140.2005
   Nieto FJ, 2000, ATHEROSCLEROSIS, V148, P131, DOI 10.1016/S0021-9150(99)00214-2
   Niles JC, 2006, NITRIC OXIDE-BIOL CH, V14, P109, DOI 10.1016/j.niox.2005.11.001
   Pacher P, 2007, PHYSIOL REV, V87, P315, DOI 10.1152/physrev.00029.2006
   Pfeiffer S, 1997, J BIOL CHEM, V272, P3465, DOI 10.1074/jbc.272.6.3465
   Powers RW, 2006, AM J OBSTET GYNECOL, V194, P160, DOI 10.1016/j.ajog.2005.06.066
   Radi R, 2001, FREE RADICAL BIO MED, V30, P463, DOI 10.1016/S0891-5849(00)00373-7
   Roberts JM, 2005, HYPERTENSION, V46, P1243, DOI 10.1161/01.HYP.0000188408.49896.c5
   Robinson KM, 2005, METHOD ENZYMOL, V396, P207, DOI 10.1016/S0076-6879(05)96019-9
   Robinson KM, 2004, ARCH BIOCHEM BIOPHYS, V423, P213, DOI 10.1016/j.abb.2003.10.011
   Sanguinetti SM, 2004, ARCH BIOCHEM BIOPHYS, V423, P302, DOI 10.1016/j.abb.2003.12.034
   Santos CXC, 1999, ARCH BIOCHEM BIOPHYS, V372, P285, DOI 10.1006/abbi.1999.1491
   Skinner KA, 1998, J BIOL CHEM, V273, P24491, DOI 10.1074/jbc.273.38.24491
   Uppu RM, 1996, ANAL BIOCHEM, V236, P242, DOI 10.1006/abio.1996.0162
   Vaccarino V, 1999, ANN INTERN MED, V131, P62, DOI 10.7326/0003-4819-131-1-199907060-00012
   VOLK KJ, 1990, J PHARMACEUT BIOMED, V8, P205, DOI 10.1016/0731-7085(90)80028-N
   Watanabe S, 2002, HYPERTENSION, V40, P355, DOI 10.1161/01.HYP.0000028589.66335.AA
   WU XW, 1992, J MOL EVOL, V34, P78, DOI 10.1007/BF00163854
   Xiong YQ, 2007, J NEUROCHEM, V100, P639, DOI 10.1111/j.1471-4159.2006.04312.x
   YUKI H, 1980, CHEM PHARM BULL, V28, P3375
   Zimmer D, 2006, J AOAC INT, V89, P786
NR 54
TC 79
Z9 89
U1 0
U2 18
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1525-7770
EI 1532-2335
J9 NUCLEOS NUCLEOT NUCL
JI Nucleosides Nucleotides Nucleic Acids
PY 2009
VL 28
IS 2
BP 118
EP 149
AR PII 908701251
DI 10.1080/15257770902736400
PG 32
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 407MQ
UT WOS:000263368800005
PM 19219741
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hayden, MR
   Tyagi, SC
AF Hayden, MR
   Tyagi, SC
TI Neural redox stress and remodeling in metabolic syndrome, type 2
   diabetes mellitus, and diabetic neuropathy
SO MEDICAL SCIENCE MONITOR
LA English
DT Review
DE atherosclerosis; atheroscleropathy; diabetic neuropathy; polyneuropathy;
   insulin resistance; endothelial nitric oxide synthase - eNOS;
   endothelial nitric oxide - eNO; extracellular matrix; prediabetes;
   oxidative stress; reactive oxygen species
ID NITRIC-OXIDE SYNTHASE; NERVE GROWTH-FACTOR; C-REACTIVE PROTEIN;
   CORONARY-HEART-DISEASE; BLOOD-BRAIN-BARRIER; RENIN-ANGIOTENSIN SYSTEM;
   TO-RETENTION HYPOTHESIS; CARPAL-TUNNEL-SYNDROME; INNATE IMMUNE-SYSTEM;
   COENZYME-A REDUCTASE
AB Diabetic polyneuropathy (DPN) is the most common complication of diabetes and may frequently be the presenting symptom in type 2 diabetes mellitus (T2DM). Metabolic syndrome and T2DM are associated with multiple metabolic toxicities. These substrate toxicities support the formation of reactive oxygen species (ROS), which are so damaging to cells, tissues and organs and play an important role in the development of multiple diabetic complications. The importance of redox stress (ROS) and their effect on the neuronal unit are discussed. There are at least 5 major pathways involved in the development of DPN: metabolic, vascular, immunologic-autoimmune, neurohormonal growth factor deficiency, and extracellular matrix neuronal unit remodeling.
   Each of these five pathways are reviewed and related to neural redox stress and the role of ROS. The identification of the toxic substrates (A-FLIGHT acronym), earlier diagnosis of T2DM at the stage of impaired glucose tolerance or impaired fasting glucose, and aggressive global risk reduction with the use of a simple RAAS acronym will assist the clinician in slowing the natural progressive history, and possibly preventing the complications associated with DPN.
   The pain, foot ulceration, limb loss, organ dysfunction, and the associated morbidity and financial burden all contribute to the need for a better understanding of DPN and the role of redox stress and global risk reduction.
C1 Univ Missouri Columbia, Dept Family & Community Med, Camdenton, MO 65020 USA.
   Univ Louisville, Sch Med, Dept Physiol & Biophys, Louisville, KY 40292 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Louisville
RP Univ Missouri Columbia, Dept Family & Community Med, POB 1140 Lk Rd 5-87, Camdenton, MO 65020 USA.
EM mrh29@usmo.com
RI Moody, Michael/H-9377-2013
CR Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Apfel SC, 2002, INT REV NEUROBIOL, V50, P393
   APFEL SC, 2000, JAMA-J AM MED ASSOC, V84, P2215
   ARAI K, 1987, BIOCHIM BIOPHYS ACTA, V924, P292, DOI 10.1016/0304-4165(87)90025-0
   Aronson D, 2001, CHRONOBIOL INT, V18, P109, DOI 10.1081/CBI-100001175
   Aronson D, 2002, CARDIOVASC DIABETOL, V1, DOI 10.1186/1475-2840-1-1
   Arruda VR, 1997, THROMB HAEMOSTASIS, V77, P818
   Audelin MC, 2001, ATHEROSCLEROSIS, V159, P497, DOI 10.1016/S0021-9150(01)00531-7
   Bakker SJL, 2000, ATHEROSCLEROSIS, V148, P17, DOI 10.1016/S0021-9150(99)00329-9
   BECKMAN JS, 1990, P NATL ACAD SCI USA, V87, P1620, DOI 10.1073/pnas.87.4.1620
   Beckman JS, 1996, AM J PHYSIOL-CELL PH, V271, pC1424
   Berry C, 2001, CURR OPIN NEPHROL HY, V10, P247, DOI 10.1097/00041552-200103000-00014
   Brodsky SV, 2001, AM J PHYSIOL-RENAL, V280, pF480, DOI 10.1152/ajprenal.2001.280.3.F480
   CAMP TM, 2003, IN PRESS DIABETOLOGI
   Carlsson P O, 2001, JOP, V2, P26
   Chiarelli F, 2000, HORM RES, V53, P53, DOI 10.1159/000023515
   Christ M, 2002, DIABETES, V51, P2648, DOI 10.2337/diabetes.51.8.2648
   Chung HY, 2001, ANN NY ACAD SCI, V928, P327
   COOPER ME, 1995, HYPERTENSION, V26, P460, DOI 10.1161/01.HYP.26.3.460
   Cucullo L, 2002, BRAIN RES, V951, P243, DOI 10.1016/S0006-8993(02)03167-0
   Delaney CL, 2001, J NEUROPATH EXP NEUR, V60, P147, DOI 10.1093/jnen/60.2.147
   Duncan B B, 2001, Sao Paulo Med J, V119, P122
   Duncan BB, 1999, DIABETES CARE, V22, P767, DOI 10.2337/diacare.22.5.767
   Duplain H, 2001, CIRCULATION, V104, P342, DOI 10.1161/01.CIR.104.3.342
   DYCK PJ, 1985, P NATL ACAD SCI USA, V82, P2513, DOI 10.1073/pnas.82.8.2513
   DYCK PJ, 1993, NEUROLOGY, V43, P817, DOI 10.1212/WNL.43.4.817
   DYCK PJ, 1985, BRAIN, V108, P861, DOI 10.1093/brain/108.4.861
   DYCK PJ, 1986, ANN NEUROL, V19, P425, DOI 10.1002/ana.410190503
   Dyck PJB, 2002, MUSCLE NERVE, V25, P477, DOI 10.1002/mus.10080
   EBENDAL T, 1992, J NEUROSCI RES, V32, P461, DOI 10.1002/jnr.490320402
   Ekberg K, 2003, DIABETES, V52, P536, DOI 10.2337/diabetes.52.2.536
   FARADJI V, 1990, ACTA NEUROL SCAND, V81, P402
   Feix A, 2001, AM J KIDNEY DIS, V38, P956, DOI 10.1053/ajkd.2001.28581
   Feldman EL, 1997, CLIN NEUROSCI, V4, P365
   Fodinger M, 1997, KIDNEY INT, V52, P517, DOI 10.1038/ki.1997.362
   Folli F, 1999, EXP CLIN ENDOCR DIAB, V107, P133, DOI 10.1055/s-0029-1212088
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   FU MX, 1994, DIABETES, V43, P676, DOI 10.2337/diabetes.43.5.676
   GIANNINI C, 1995, ANN NEUROL, V37, P498, DOI 10.1002/ana.410370412
   GIUGLIANO D, 1995, METABOLISM, V44, P363, DOI 10.1016/0026-0495(95)90167-1
   Gotto AM, 1998, AM J CARDIOL, V82, p22Q
   Grandis M, 2001, MUSCLE NERVE, V24, P622, DOI 10.1002/mus.1047
   Griendling KK, 2000, CIRC RES, V86, P494, DOI 10.1161/01.RES.86.5.494
   Griendling KK, 2001, J CLIN INVEST, V108, P1423, DOI 10.1172/JCI14453
   Grundy SM, 1998, AM J CARDIOL, V81, p18B, DOI 10.1016/S0002-9149(98)00033-2
   Guiot Y, 2001, DIABETES, V50, pS188, DOI 10.2337/diabetes.50.2007.S188
   Guzik TJ, 2002, CIRCULATION, V105, P1656, DOI 10.1161/01.CIR.0000012748.58444.08
   Hafer-Macko CE, 2002, DIABETES, V51, P1957, DOI 10.2337/diabetes.51.6.1957
   Hansen SH, 2001, DIABETES-METAB RES, V17, P330, DOI 10.1002/dmrr.229
   HANSSON HA, 1986, ACTA PHYSIOL SCAND, V126, P609, DOI 10.1111/j.1748-1716.1986.tb07862.x
   Harman D, 1998, EXP GERONTOL, V33, P95, DOI 10.1016/S0531-5565(97)00059-4
   Hayden M R, 2002, Mo Med, V99, P495
   Hayden M R, 2001, JOP, V2, P124
   Hayden Melvin R, 2004, Nutr Metab (Lond), V1, P10, DOI 10.1186/1743-7075-1-10
   Hayden MR, 2004, CARDIOVASC DIABETOL, V3, DOI 10.1186/1475-2840-3-1
   Hayden MR, 2004, NUTR J, V3, DOI 10.1186/1475-2891-3-4
   Hayden MR, 2003, CARDIOVASC DIABETOL, V2, DOI 10.1186/1475-2840-2-2
   Hayden Melvin R, 2003, Med Sci Monit, V9, pSR35
   Hayden Melvin R, 2002, JOP, V3, P86
   Hayden MR, 2002, CARDIOVASC DIABETOL, V1, DOI 10.1186/1475-2840-1-3
   Hayden Melvin R, 2002, JOP, V3, P126
   Hayden MR, 2000, SOUTHERN MED J, V93, P24
   HAYDEN MR, 2004, MED HYPOTHESIS RES, V1, P171
   HELLWEG R, 1990, J NEUROSCI RES, V26, P258, DOI 10.1002/jnr.490260217
   Hill RE, 2002, J ANAT, V201, P185, DOI 10.1046/j.1469-7580.2002.00083.x
   Hilz MJ, 2000, FORTSCHR NEUROL PSYC, V68, P278, DOI 10.1055/s-2000-11535
   Hoffmann J, 2001, CIRC RES, V89, P709, DOI 10.1161/hh2001.097796
   HUNT JV, 1990, DIABETES, V39, P1420, DOI 10.2337/diabetes.39.11.1420
   Ido Y, 1996, NEPHROL DIAL TRANSPL, V11, P72
   Ihara Y, 1999, DIABETES, V48, P927, DOI 10.2337/diabetes.48.4.927
   Ikeda T, 2001, METABOLISM, V50, P763, DOI 10.1053/meta.2001.24200
   Jacques PF, 1996, CIRCULATION, V93, P7, DOI 10.1161/01.CIR.93.1.7
   Janson J, 1999, DIABETES, V48, P491, DOI 10.2337/diabetes.48.3.491
   JENNINGS PE, 1987, DIABETES RES CLIN EX, V6, P151
   Johnson PJ, 1998, VET REC, V142, P392, DOI 10.1136/vr.142.15.392
   Jones LC, 2001, DIABETES, V50, pS186, DOI 10.2337/diabetes.50.2007.S186
   Kahn SE, 1999, DIABETES, V48, P241, DOI 10.2337/diabetes.48.2.241
   Kailasam MT, 2000, J HYPERTENS, V18, P1611, DOI 10.1097/00004872-200018110-00012
   Katsuyama K, 1998, ENDOCRINOLOGY, V139, P4506, DOI 10.1210/en.139.11.4506
   Keane WF, 1999, KIDNEY INT, V56, pS1
   Kilo S, 2000, NEUROLOGY, V54, P1246, DOI 10.1212/WNL.54.6.1246
   Kim WK, 2000, YONSEI MED J, V41, P123, DOI 10.3349/ymj.2000.41.1.123
   Lamarche B, 1998, JAMA-J AM MED ASSOC, V279, P1955, DOI 10.1001/jama.279.24.1955
   Lee Y, 1997, DIABETES, V46, P408, DOI 10.2337/diabetes.46.3.408
   LEE Y, 1994, P NATL ACAD SCI USA, V91, P10878, DOI 10.1073/pnas.91.23.10878
   Lemieux I, 2001, ARTERIOSCL THROM VAS, V21, P961, DOI 10.1161/01.ATV.21.6.961
   Lenaz G, 1998, BBA-BIOENERGETICS, V1366, P53, DOI 10.1016/S0005-2728(98)00120-0
   Li H, 2002, CIRCULATION, V105, P1037, DOI 10.1161/hc0902.104713
   Libby P, 2002, SCI AM, V286, P47
   Litchfield JE, 1999, INT J BIOCHEM CELL B, V31, P1297, DOI 10.1016/S1357-2725(99)00091-6
   Ma XY, 2001, CIRC RES, V88, P787, DOI 10.1161/hh0801.089542
   Maejima K, 2001, J DIABETES COMPLICAT, V15, P135, DOI 10.1016/S1056-8727(01)00144-1
   Malik RA, 2000, ANN MED, V32, P1, DOI 10.3109/07853890008995903
   Malik RA, 1998, LANCET, V352, P1978, DOI 10.1016/S0140-6736(98)02478-7
   McFarlane SI, 2001, J CLIN ENDOCR METAB, V86, P713, DOI 10.1210/jc.86.2.713
   McGarry JD, 2002, DIABETES, V51, P7, DOI 10.2337/diabetes.51.1.7
   McKenzie D, 1999, J NEUROL SCI, V162, P84, DOI 10.1016/S0022-510X(98)00303-7
   Miyamoto Y, 1998, HYPERTENSION, V32, P3, DOI 10.1161/01.HYP.32.1.3
   Mooradian AD, 1997, BRAIN RES REV, V23, P210, DOI 10.1016/S0165-0173(97)00003-9
   Mujumdar VS, 2001, J CELL BIOCHEM, V82, P491, DOI 10.1002/jcb.1175
   Münzel T, 2001, CIRCULATION, V104, P1571, DOI 10.1161/hc3801.095585
   Nash DT, 2002, JAMA-J AM MED ASSOC, V287, P1451, DOI 10.1001/jama.287.11.1451
   Nickenig G, 1998, CIRCULATION, V98, P2453, DOI 10.1161/01.CIR.98.22.2453
   Nishikawa T, 2000, NATURE, V404, P787, DOI 10.1038/35008121
   OBEID LM, 1993, SCIENCE, V259, P1769, DOI 10.1126/science.8456305
   OBERLEY LW, 1988, FREE RADICAL BIO MED, V5, P113, DOI 10.1016/0891-5849(88)90036-6
   Pecoits R, 2002, NEPHROL DIAL TRANSPL, V17, P28, DOI 10.1093/ndt/17.suppl_11.28
   Pennathur S, 2001, J CLIN INVEST, V107, P853, DOI 10.1172/JCI11194
   Perkins BA, 2002, DIABETES CARE, V25, P565, DOI 10.2337/diacare.25.3.565
   Pickup JC, 1997, DIABETOLOGIA, V40, P1286, DOI 10.1007/s001250050822
   Pickup JC, 1998, DIABETOLOGIA, V41, P1241, DOI 10.1007/s001250051058
   Pierson CR, 2002, J NEUROPATH EXP NEUR, V61, P857, DOI 10.1093/jnen/61.10.857
   Pietropaolo M, 2000, DIABETES, V49, P32, DOI 10.2337/diabetes.49.1.32
   Poitout V, 2002, ENDOCRINOLOGY, V143, P339, DOI 10.1210/en.143.2.339
   Polydefkis M, 2003, JAMA-J AM MED ASSOC, V290, P1371, DOI 10.1001/jama.290.10.1371
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Pradhan AD, 2002, EUR HEART J, V23, P831, DOI 10.1053/euhj.2001.3052
   Reaven G, 2002, CIRCULATION, V106, P286, DOI 10.1161/01.CIR.0000019884.36724.D9
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   REJA A, 1995, DIABETIC MED, V12, P307, DOI 10.1111/j.1464-5491.1995.tb00482.x
   Ridker PM, 1997, NEW ENGL J MED, V336, P973, DOI 10.1056/NEJM199704033361401
   Ridker PM, 2000, NEW ENGL J MED, V342, P836, DOI 10.1056/NEJM200003233421202
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   SANDEMAN DD, 1994, HAEMOSTASIS THROMBOS, P1291
   Schratzberger P, 2001, J CLIN INVEST, V107, P1083, DOI 10.1172/JCI12188
   Shah GN, 1997, EXP GERONTOL, V32, P501, DOI 10.1016/S0531-5565(96)00158-1
   Shimabukuro M, 1998, J BIOL CHEM, V273, P32487, DOI 10.1074/jbc.273.49.32487
   Shimabukuro M, 1998, P NATL ACAD SCI USA, V95, P2498, DOI 10.1073/pnas.95.5.2498
   Sima AAF, 2003, EXPERT OPIN INV DRUG, V12, P1471
   Sima AAF, 1997, CLIN NEUROSCI, V4, P359
   Sima AAF, 2001, DIABETOLOGIA, V44, P889, DOI 10.1007/s001250100570
   Simmons Z, 2002, CURR OPIN NEUROL, V15, P595, DOI 10.1097/00019052-200210000-00010
   Simon DI, 1996, P NATL ACAD SCI USA, V93, P4736, DOI 10.1073/pnas.93.10.4736
   Simovic D, 1999, CIRCULATION, V100, P770
   Simovic D, 2001, ARCH NEUROL-CHICAGO, V58, P761, DOI 10.1001/archneur.58.5.761
   Sinclair AJ, 1992, EXS, V62, P151
   Siperstein M D, 1966, Trans Assoc Am Physicians, V79, P330
   Sood HS, 2003, AM J PHYSIOL-LUNG C, V284, pL333, DOI 10.1152/ajplung.00183.2002
   Sowers J R, 2001, Clin Cornerstone, V4, P17, DOI 10.1016/S1098-3597(01)90026-2
   Stepp DW, 2002, AM J PHYSIOL-HEART C, V283, pH750, DOI 10.1152/ajpheart.00029.2002
   STEVENS MJ, 1995, DIABETIC MED, V12, P566, DOI 10.1111/j.1464-5491.1995.tb00544.x
   Stühlinger MC, 2001, CIRCULATION, V104, P2569, DOI 10.1161/hc4601.098514
   Stühlinger MC, 2002, JAMA-J AM MED ASSOC, V287, P1420, DOI 10.1001/jama.287.11.1420
   Sugimoto K, 1997, DIABETOLOGIA, V40, P1380, DOI 10.1007/s001250050839
   Syed MA, 2002, DIABETES NUTR METAB, V15, P68
   Tahmasebi M, 1999, J ENDOCRINOL, V161, P317, DOI 10.1677/joe.0.1610317
   Tham M, 2001, REGUL PEPTIDES, V101, P51, DOI 10.1016/S0167-0115(01)00260-9
   Thomas HE, 2002, DIABETES, V51, P311, DOI 10.2337/diabetes.51.2.311
   Thrailkill K M, 2000, Diabetes Technol Ther, V2, P69, DOI 10.1089/152091599316775
   Tyagi SC, 2003, HEART FAIL REV, V8, P23, DOI 10.1023/A:1022138803293
   Uemura S, 2001, CIRC RES, V88, P1291, DOI 10.1161/hh1201.092042
   UNGER RH, 1995, DIABETES, V44, P863, DOI 10.2337/diabetes.44.8.863
   Unger RH, 2001, FASEB J, V15, P312, DOI 10.1096/fj.00-0590
   Vásquez-Vivar J, 1998, P NATL ACAD SCI USA, V95, P9220, DOI 10.1073/pnas.95.16.9220
   Verma S, 2002, CIRCULATION, V106, P913, DOI 10.1161/01.CIR.0000029802.88087.5E
   Vinik AI, 2002, SOUTHERN MED J, V95, P21
   Vozarova B, 2002, DIABETES, V51, P455, DOI 10.2337/diabetes.51.2.455
   Wahren J, 2000, AM J PHYSIOL-ENDOC M, V278, pE759, DOI 10.1152/ajpendo.2000.278.5.E759
   Wajchenberg BL, 2000, ENDOCR REV, V21, P697, DOI 10.1210/er.21.6.697
   Wang F, 2001, DIABETES, V50, P2514, DOI 10.2337/diabetes.50.11.2514
   Weber F, 2002, MUSCLE NERVE, V26, P471, DOI 10.1002/mus.10235
   Weigert C, 2002, DIABETOLOGIA, V45, P890, DOI 10.1007/s00125-002-0843-4
   Weiss N, 2002, ARTERIOSCL THROM VAS, V22, P34, DOI 10.1161/hq1201.100456
   Wendt Thoralf, 2002, Curr Atheroscler Rep, V4, P228, DOI 10.1007/s11883-002-0024-4
   WILLIAMS KJ, 1995, ARTERIOSCL THROM VAS, V15, P551, DOI 10.1161/01.ATV.15.5.551
   Williams KJ, 1998, CURR OPIN LIPIDOL, V9, P471, DOI 10.1097/00041433-199810000-00012
   Williamson JR, 1999, DIABETES RES CLIN PR, V45, P81
   WILLIAMSON JR, 1993, DIABETES, V42, P801, DOI 10.2337/diabetes.42.6.801
   Winer S, 2003, NAT MED, V9, P198, DOI 10.1038/nm818
   Wong TY, 2002, JAMA-J AM MED ASSOC, V287, P2528, DOI 10.1001/jama.287.19.2528
   Woo KS, 1999, J AM COLL CARDIOL, V34, P2002, DOI 10.1016/S0735-1097(99)00469-6
   Yamamoto Y, 2001, J CLIN INVEST, V108, P261, DOI 10.1172/JCI11771
   Ye JM, 2001, AM J PHYSIOL-ENDOC M, V280, pE562, DOI 10.1152/ajpendo.2001.280.4.E562
   YOUNG MJ, 1995, DIABETOLOGIA, V38, P1051, DOI 10.1007/s001250050390
   Younger DS, 1997, MUSCLE NERVE, V20, P520
   Yudkin JS, 2002, DIABETOLOGIA, V45, P327, DOI 10.1007/s00125-001-0756-7
   Yudkin JS, 2000, ATHEROSCLEROSIS, V148, P209, DOI 10.1016/S0021-9150(99)00463-3
   Zethelius B, 2002, CIRCULATION, V105, P2153, DOI 10.1161/01.CIR.0000015855.04844.E7
   Zhang XH, 2000, AM J PHYSIOL-RENAL, V279, pF671, DOI 10.1152/ajprenal.2000.279.4.F671
   Zhuang HX, 1996, EXP NEUROL, V140, P198, DOI 10.1006/exnr.1996.0129
   ZIMMET PZ, 1994, DIABETIC MED, V11, P299, DOI 10.1111/j.1464-5491.1994.tb00275.x
   Zou MH, 2002, J CLIN INVEST, V109, P817, DOI 10.1172/JCI200214442
NR 182
TC 22
Z9 25
U1 0
U2 7
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD DEC
PY 2004
VL 10
IS 12
BP RA291
EP RA307
PG 17
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 880OQ
UT WOS:000225799500022
PM 15567993
DA 2025-06-11
ER

PT J
AU Hauck, AK
   Zhou, T
   Hahn, W
   Petegrosso, R
   Kuang, R
   Chen, Y
   Bernlohr, DA
AF Hauck, Amy K.
   Zhou, Tong
   Hahn, Wendy
   Petegrosso, Raphael
   Kuang, Rui
   Chen, Yue
   Bernlohr, David A.
TI Obesity-induced protein carbonylation in murine adipose tissue regulates
   the DNA-binding domain of nuclear zinc finger proteins
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
DE oxidative stress; zinc finger; adipose tissue; nuclear receptor;
   obesity; carbonylation; zinc finger proteins; nucleus; estrogen-related
   receptor; reactive oxygen species; metabolic syndrome; transcription
   factor
ID LARGE GENE LISTS; OXIDATIVE STRESS; ERR-GAMMA; INSULIN-RESISTANCE;
   PROTEOMIC ANALYSIS; METABOLIC SYNDROME; ACID OXIDATION; ALDEHYDES;
   PRODUCT; IDENTIFICATION
AB In obesity-linked insulin resistance, oxidative stress in adipocytes leads to lipid peroxidation and subsequent carbonylation of proteins by diffusible lipid electrophiles. Reduction in oxidative stress attenuates protein carbonylation and insulin resistance, suggesting that lipid modification of proteins may play a role in metabolic disease, but the mechanisms remain incompletely understood. Herein, we show that in vivo, diet-induced obesity in mice surprisingly results in preferential carbonylation of nuclear proteins by 4-hydroxy-trans-2,3-nonenal (4-HNE) or 4-hydroxy-trans-2,3-hexenal (4-HHE). Proteomic and structural analyses revealed that residues in or around the sites of zinc coordination of zinc finger proteins, such as those containing the C2H2 or MATRIN, RING, C3H1, or N4-type DNA-binding domains, are particularly susceptible to carbonylation by lipid aldehydes. These observations strongly suggest that carbonylation functionally disrupts protein secondary structure supported by metal coordination. Analysis of one such target, the nuclear protein estrogen-related receptor (ERR-), showed that ERR- is modified by 4-HHE in the obese state. In vitro carbonylation decreased the DNA-binding capacity of ERR- and correlated with the obesity-linked down-regulation of many key genes promoting mitochondrial bioenergetics. Taken together, these findings reveal a novel mechanistic connection between oxidative stress and metabolic dysfunction arising from carbonylation of nuclear zinc finger proteins, such as the transcriptional regulator ERR-.
C1 [Hauck, Amy K.; Zhou, Tong; Hahn, Wendy; Chen, Yue; Bernlohr, David A.] Univ Minnesota Twin Cities, Dept Biochem Mol Biol & Biophys, Minneapolis, MN 55455 USA.
   [Petegrosso, Raphael; Kuang, Rui] Univ Minnesota Twin Cities, Dept Comp Sci & Engn, Minneapolis, MN 55455 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities
RP Bernlohr, DA (corresponding author), Univ Minnesota Twin Cities, Dept Biochem Mol Biol & Biophys, Minneapolis, MN 55455 USA.
EM bernl001@umn.edu
FU National Institutes of Health [R01 DK084669, T32 GM008347]; Minnesota
   Agricultural Experiment Station; CAPES Foundation, Ministry of Education
   of Brazil [BEX 13250/13-2]
FX This work was supported by National Institutes of Health Grant R01
   DK084669 and the Minnesota Agricultural Experiment Station (to D.A.B.),
   National Institutes of Health Grant T32 GM008347 (to A.K.H.), and the
   CAPES Foundation, Ministry of Education of Brazil (BEX 13250/13-2) (to
   R.P.). The authors declare that they have no conflicts of interest with
   the contents of this article. The content is solely the responsibility
   of the authors and does not necessarily represent the official views of
   the National Institutes of Health.
CR Andringa KK, 2014, REDOX BIOL, V2, P1038, DOI 10.1016/j.redox.2014.09.006
   Atsriku C, 2005, J AM SOC MASS SPECTR, V16, P2017, DOI 10.1016/j.jasms.2005.08.009
   Awada M, 2012, J LIPID RES, V53, P2069, DOI 10.1194/jlr.M026179
   Ayyadevara S, 2005, AGING CELL, V4, P257, DOI 10.1111/j.1474-9726.2005.00168.x
   Boden G, 2015, SCI TRANSL MED, V7, DOI 10.1126/scitranslmed.aac4765
   BRUENNER BA, 1995, CHEM RES TOXICOL, V8, P552, DOI 10.1021/tx00046a009
   Chavez JD, 2011, J PROTEOMICS, V74, P2417, DOI 10.1016/j.jprot.2011.03.031
   Chou Michael F, 2011, Curr Protoc Bioinformatics, VChapter 13, DOI [10.1002/0471250953.bi1315s35, 10.1002/0471250953.bi1316s36]
   Cox J, 2008, NAT BIOTECHNOL, V26, P1367, DOI 10.1038/nbt.1511
   Curtis JM, 2012, J BIOL CHEM, V287, P32967, DOI 10.1074/jbc.M112.400663
   Curtis JM, 2012, TRENDS ENDOCRIN MET, V23, P399, DOI 10.1016/j.tem.2012.05.008
   Curtis JM, 2010, DIABETES, V59, P1132, DOI 10.2337/db09-1105
   Dixen K, 2013, OBESITY, V21, P516, DOI 10.1002/oby.20067
   Dixon SJ, 2012, CELL, V149, P1060, DOI 10.1016/j.cell.2012.03.042
   Ecco G, 2017, DEVELOPMENT, V144, P2719, DOI 10.1242/dev.132605
   Eichner LJ, 2011, MITOCHONDRION, V11, P544, DOI 10.1016/j.mito.2011.03.121
   ESTERBAUER H, 1991, FREE RADICAL BIO MED, V11, P81, DOI 10.1016/0891-5849(91)90192-6
   Fedotova AA, 2017, ACTA NATURAE, V9, P47, DOI 10.32607/20758251-2017-9-2-47-58
   Frohnert BI, 2014, DIABETES, V63, P89, DOI 10.2337/db13-0777
   Frohnert BI, 2011, OBESITY, V19, P1735, DOI 10.1038/oby.2011.115
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Galinier A, 2006, J BIOL CHEM, V281, P12682, DOI 10.1074/jbc.M506949200
   Garton M, 2015, NUCLEIC ACIDS RES, V43, P9147, DOI 10.1093/nar/gkv919
   Grimsrud PA, 2008, J BIOL CHEM, V283, P21837, DOI 10.1074/jbc.R700019200
   Grimsrud PA, 2007, MOL CELL PROTEOMICS, V6, P624, DOI 10.1074/mcp.M600120-MCP200
   Guéraud F, 2010, FREE RADICAL RES, V44, P1098, DOI 10.3109/10715762.2010.498477
   Hahn WS, 2014, AM J PHYSIOL-ENDOC M, V306, pE1033, DOI 10.1152/ajpendo.00422.2013
   Hamdy O, 2006, CURR DIABETES REV, V2, P367, DOI 10.2174/1573399810602040367
   Hauck AK, 2016, J LIPID RES, V57, P1976, DOI 10.1194/jlr.R066597
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Huang DW, 2009, NAT PROTOC, V4, P44, DOI 10.1038/nprot.2008.211
   Huang DW, 2009, NUCLEIC ACIDS RES, V37, P1, DOI 10.1093/nar/gkn923
   Ilbert M, 2006, ANTIOXID REDOX SIGN, V8, P835, DOI 10.1089/ars.2006.8.835
   Iuchi S, 2001, CELL MOL LIFE SCI, V58, P625, DOI 10.1007/PL00000885
   Keller MP, 2008, GENOME RES, V18, P706, DOI 10.1101/gr.074914.107
   Kida YS, 2015, CELL STEM CELL, V16, P547, DOI 10.1016/j.stem.2015.03.001
   Kristal BS, 1996, J BIOL CHEM, V271, P6033, DOI 10.1074/jbc.271.11.6033
   Kröncke KD, 2009, ANTIOXID REDOX SIGN, V11, P1015, DOI [10.1089/ars.2008.2269, 10.1089/ARS.2008.2269]
   Long EK, 2008, J NEUROCHEM, V105, P714, DOI 10.1111/j.1471-4159.2007.05175.x
   Long EK, 2013, FREE RADICAL BIO MED, V63, P390, DOI 10.1016/j.freeradbiomed.2013.05.030
   Mi HY, 2017, NUCLEIC ACIDS RES, V45, pD183, DOI 10.1093/nar/gkw1138
   Misra J, 2017, TRENDS ENDOCRIN MET, V28, P261, DOI 10.1016/j.tem.2016.12.005
   Moller IM, 2011, J PROTEOMICS, V74, P2228, DOI 10.1016/j.jprot.2011.05.004
   NADKARNI DV, 1995, CHEM RES TOXICOL, V8, P284, DOI 10.1021/tx00044a014
   Pace NJ, 2014, BIOMOLECULES, V4, P419, DOI 10.3390/biom4020419
   Rappsilber J, 2007, NAT PROTOC, V2, P1896, DOI 10.1038/nprot.2007.261
   Requena JR, 2001, P NATL ACAD SCI USA, V98, P69, DOI 10.1073/pnas.011526698
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Schwartz D, 2005, NAT BIOTECHNOL, V23, P1391, DOI 10.1038/nbt1146
   Shearn CT, 2015, FREE RADICAL BIO MED, V89, P1144, DOI 10.1016/j.freeradbiomed.2015.10.420
   Shearn CT, 2016, REDOX BIOL, V7, P68, DOI 10.1016/j.redox.2015.11.013
   STUDENT AK, 1980, J BIOL CHEM, V255, P4745
   UCHIDA K, 1993, P NATL ACAD SCI USA, V90, P8742, DOI 10.1073/pnas.90.18.8742
   Uchida K, 2003, PROG LIPID RES, V42, P318, DOI 10.1016/S0163-7827(03)00014-6
   Vigilanza P, 2011, J CELL PHYSIOL, V226, P2016, DOI 10.1002/jcp.22542
   Vizcaíno JA, 2016, NUCLEIC ACIDS RES, V44, pD447, DOI 10.1093/nar/gkv1145
   Wang T, 2015, MOL CELL BIOL, V35, P1281, DOI 10.1128/MCB.01156-14
   Wong CM, 2008, CIRC RES, V102, P310, DOI 10.1161/CIRCRESAHA.107.159814
   Wong HL, 2008, CHEM RES TOXICOL, V21, P796, DOI 10.1021/tx700433m
   Xu QH, 2014, METHOD ENZYMOL, V538, P249, DOI 10.1016/B978-0-12-800280-3.00014-1
   Yoshihara E, 2016, CELL METAB, V23, P622, DOI 10.1016/j.cmet.2016.03.005
NR 61
TC 17
Z9 20
U1 0
U2 9
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD AUG 31
PY 2018
VL 293
IS 35
BP 13464
EP 13476
DI 10.1074/jbc.RA118.003469
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA GS2JV
UT WOS:000443375500010
PM 30012885
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Kanagasabai, T
   Ardern, CI
AF Kanagasabai, Thirumagal
   Ardern, Chris I.
TI Contribution of Inflammation, Oxidative Stress, and Antioxidants to the
   Relationship between Sleep Duration and Cardiometabolic Health
SO SLEEP
LA English
DT Article
DE antioxidants; cardiometabolic health; indirect mediation effect;
   inflammation and oxidative stress; sleep duration
ID GAMMA-GLUTAMYL-TRANSFERASE; BODY-MASS INDEX; SERUM URIC-ACID; METABOLIC
   SYNDROME; BLOOD-PRESSURE; VITAMIN-C; CARDIOVASCULAR RISK; APNEA
   SYNDROME; US ADULTS; ATHEROSCLEROSIS
AB Objectives: To explore the interrelationship and mediating effect of factors that are beneficial (i.e., antioxidants) and harmful (i.e., inflammation and oxidative stress) to the relationship between sleep and cardiometabolic health.
   Design: Cross-sectional data from the 2005-2006 National Health and Nutrition Examination Survey.
   Setting: Nationally representative population sample from the US.
   Participants: Age >= 20 y with sleep data; final analytical sample of n = 2,079.
   Interventions: N/A.
   Measurements and Results: Metabolic syndrome was classified according to the Joint Interim Statement, and sleep duration was categorized as very short, short, adequate, and long sleepers (<= 4, 5-6, 7-8, and = 9 h per night, respectively). The indirect mediation effect was quantified as large (>= 0.25), moderate (>= 0.09), modest (>= 0.01), and weak (< 0.01). In general, inflammation was above the current clinical reference range across all sleep duration categories, whereas oxidative stress was elevated among short and very short sleepers. Select sleep duration-cardiometabolic health relationships were mediated by C-reactive protein (CRP),gamma-glutamyl transferase (GGT), carotenoids, uric acid, and vitamins C and D, and were moderated by sex. Specifically, moderate-to-large indirect mediation by GGT, carotenoids, uric acid, and vitamin D were found for sleep duration-waist circumference and -systolic blood pressure relationships, whereas vitamin C was a moderate mediator of the sleep duration-diastolic blood pressure relationship.
   Conclusions: Several factors related to inflammation, oxidative stress, and antioxidant status were found to lie on the casual pathway of the sleep duration-cardiometabolic health relationship. Further longitudinal studies are needed to confirm our results.
C1 [Kanagasabai, Thirumagal; Ardern, Chris I.] York Univ, Sch Kinesiol & Hlth Sci, Toronto, ON M3J 1P3, Canada.
C3 York University - Canada
RP Ardern, CI (corresponding author), York Univ, Sch Kinesiol & Hlth Sci, 352 Norman Bethune Coll, Toronto, ON M3J 1P3, Canada.
EM cardern@yorku.ca
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   AMA, SI CONV CALC AMA MAN
   [Anonymous], J METABOLIC SYNDROME
   [Anonymous], PHYS ACT GUID AM
   Bates CJ, 1998, J HYPERTENS, V16, P925, DOI 10.1097/00004872-199816070-00005
   Beydoun MA, 2011, J NUTR, V141, P903, DOI 10.3945/jn.110.136580
   Bo S, 2005, WORLD J GASTROENTERO, V11, P7109, DOI 10.3748/wjg.v11.i45.7109
   Brady EM, 2012, METAB SYNDR RELAT D, V10, P152, DOI 10.1089/met.2011.0073
   Cheng S, 2010, DIABETES, V59, P242, DOI 10.2337/db09-1011
   Cheung BMY, 2011, CLIN CHIM ACTA, V412, P1326, DOI 10.1016/j.cca.2011.03.030
   De Bona KS, 2013, INFLAMMATION, V36, P1539, DOI 10.1007/s10753-013-9697-9
   Festa A, 2002, DIABETES, V51, P1131, DOI 10.2337/diabetes.51.4.1131
   Ford ES, 2005, DIABETES CARE, V28, P1228, DOI 10.2337/diacare.28.5.1228
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Fotherby MD, 2000, J HYPERTENS, V18, P411, DOI 10.1097/00004872-200018040-00009
   Gangwisch JE, 2005, SLEEP, V28, P1289, DOI 10.1093/sleep/28.10.1289
   Grebe M, 2006, AM J RESP CRIT CARE, V173, P897, DOI 10.1164/rccm.200508-1223OC
   Johnston CS, 2007, J NUTR, V137, P1757, DOI 10.1093/jn/137.7.1757
   Ju SY, 2013, NUTR DIABETES, V3, DOI 10.1038/nutd.2013.8
   Kanbay A, 2011, RESP MED, V105, P637, DOI 10.1016/j.rmed.2010.12.003
   Kenny DA, 2013, MEDIATION
   Khansari N, 2009, RECENT PATENTS INFLA, V3, P73, DOI 10.2174/187221309787158371
   Li Q, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-72
   Lin QC, 2014, EUR ARCH OTO-RHINO-L, V271, P825, DOI 10.1007/s00405-013-2669-8
   Mangge H, 2010, CURR MED CHEM, V17, P4511, DOI 10.2174/092986710794183006
   Masuo K, 2003, HYPERTENSION, V42, P474, DOI 10.1161/01.HYP.0000091371.53502.D3
   McCarty DE, 2014, SLEEP MED REV, V18, P311, DOI 10.1016/j.smrv.2013.07.001
   Murri M, 2009, TRANSL RES, V154, P111, DOI 10.1016/j.trsl.2009.06.001
   NCHS, NHANES NHANES 2005 2
   NCHS, NHANES NAT HLTH NUTR
   Ness AR, 1997, J HUM HYPERTENS, V11, P343, DOI 10.1038/sj.jhh.1000423
   Ohida T, 2001, SLEEP, V24, P333, DOI 10.1093/sleep/24.3.333
   Oyama J, 2012, CLIN CARDIOL, V35, P231, DOI 10.1002/clc.21010
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   Russo A, 2008, EUR J CANCER, V44, P293, DOI 10.1016/j.ejca.2007.11.005
   Scrivo R, 2011, AUTOIMMUN REV, V10, P369, DOI 10.1016/j.autrev.2010.12.006
   Sharifian Akbar, 2005, J Circadian Rhythms, V3, P15, DOI 10.1186/1740-3391-3-15
   Sluijs I, 2009, J NUTR, V139, P987, DOI 10.3945/jn.108.101451
   Svendsen M, 2007, EUR J CLIN NUTR, V61, P1301, DOI 10.1038/sj.ejcn.1602652
   Tamakoshi A, 2004, SLEEP, V27, P51
   Van Cauter E, 2008, SLEEP MED, V9, pS23, DOI 10.1016/S1389-9457(08)70013-3
   van de Water ATM, 2011, J SLEEP RES, V20, P183, DOI 10.1111/j.1365-2869.2009.00814.x
   Witham MD, 2009, J HYPERTENS, V27, P1948, DOI 10.1097/HJH.0b013e32832f075b
NR 43
TC 62
Z9 69
U1 3
U2 27
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
EI 1550-9109
J9 SLEEP
JI Sleep
PD DEC 1
PY 2015
VL 38
IS 12
BP 1905
EP 1912
DI 10.5665/sleep.5238
PG 8
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CX3RH
UT WOS:000365616300014
PM 26237775
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Tinkov, AA
   Ajsuvakova, OP
   Skalnaya, MG
   Popova, EV
   Sinitskii, AI
   Nemereshina, ON
   Gatiatulina, ER
   Nikonorov, AA
   Skalny, AV
AF Tinkov, Alexey A.
   Ajsuvakova, Olga P.
   Skalnaya, Margarita G.
   Popova, Elizaveta V.
   Sinitskii, Anton I.
   Nemereshina, Olga N.
   Gatiatulina, Evgenia R.
   Nikonorov, Alexandr A.
   Skalny, Anatoly V.
TI Mercury and metabolic syndrome: a review of experimental and clinical
   observations
SO BIOMETALS
LA English
DT Review
DE Mercury; Toxicity; Obesity; Insulin resistance; Hypertension;
   Dyslipidemia; Atherosclerosis
ID ENDOPLASMIC-RETICULUM STRESS; KOREA NATIONAL-HEALTH; PRENATAL
   METHYLMERCURY EXPOSURE; INCREASED OXIDATIVE STRESS;
   CORONARY-HEART-DISEASE; NF-KAPPA-B; LIPID-PEROXIDATION; IN-VITRO;
   SUPEROXIDE-DISMUTASE; INSULIN-RESISTANCE
AB A significant interrelation between heavy metal exposure and metabolic syndrome (MetS) development has been demonstrated earlier. Despite the presence of a number of works aimed at the investigation of the role of Hg in MetS development, the existing data remain contradictory. Therefore, the primary objective of the current work is to review the existing data regarding the influence of mercury on universal mechanisms involved in the pathogenesis of the development of MetS and its components. The brief chemical characterization of mercury is provided. The role of mercury in induction of oxidative stress has been discussed. In particular, Hg-induced oxidative stress may occur due to both prooxidant action of the metal and decrease in antioxidant enzymes. Despite the absence of direct indications, it can be proposed that mercury may induce endoplasmic reticulum stress. As it is seen from both in vivo and in vitro studies, mercury is capable of inducing inflammation. The reviewed data demonstrate that mercury affects universal pathogenetic mechanisms of MetS development. Moreover, multiple investigations have indicated the role of mercury in pathogenesis of MetS components: dyslipidemia, hypertension, insulin resistance, and obesity to a lesser extent. The present state of data regarding the interrelation between mercury and MetS denotes the following perspectives: (1) Further clinic-epidemiologic and experimental studies are required to estimate the association between mercury exposure and the development of MetS components, especially obesity; (2) Additional investigations of the possible effect of organism's mercury content modulation on MetS pathogenesis should be undertaken.
C1 [Tinkov, Alexey A.; Skalny, Anatoly V.] Yaroslavl State Univ, Lab Biotechnol & Appl Bioelementol, Yaroslavl 150000, Russia.
   [Tinkov, Alexey A.; Popova, Elizaveta V.; Nemereshina, Olga N.; Gatiatulina, Evgenia R.; Nikonorov, Alexandr A.] Orenburg State Med Acad, Dept Biochem, Orenburg 460000, Russia.
   [Ajsuvakova, Olga P.] Orenburg State Agr Univ, Dept Chem, Orenburg 460014, Russia.
   [Ajsuvakova, Olga P.] Orenburg State Pedag Univ, Dept Chem & Methods Chem Teaching, Orenburg 460014, Russia.
   [Skalnaya, Margarita G.; Skalny, Anatoly V.] Russian Soc Trace Elements Med, ANO Ctr Biot Med, Moscow 105064, Russia.
   [Sinitskii, Anton I.] South Ural State Med Univ, Pharmaceut Fac, Dept Chem, Chelyabinsk 453092, Russia.
   [Skalny, Anatoly V.] Orenburg State Univ, Inst Bioelementol, Russian Satellite Ctr Trace Element, Inst UNESCO, Orenburg 460352, Russia.
C3 Yaroslavl State University; Orenburg State Pedagogical University; South
   Ural State Medical University; Orenburg State University
RP Tinkov, AA (corresponding author), Yaroslavl State Univ, Lab Biotechnol & Appl Bioelementol, Sovetskaya St 14, Yaroslavl 150000, Russia.
EM tinkov.a.a@gmail.com
RI Skalny, Anatoly/J-3953-2019; Ajsuvakova, Olga/N-6595-2016; Nikonorova,
   Eugenia/AAQ-5445-2020; Sinitskii, Anton/D-6010-2014; Tinkov,
   Alexey/H-5842-2016; Skalny, Anatolij Viktorovich/F-2906-2015
OI Nikonorov, Alexandr/0000-0001-7214-8176; Skalnaya,
   Margarita/0000-0003-1099-2560; Sinitskii, Anton/0000-0001-5687-3976;
   Tinkov, Alexey/0000-0003-0348-6192; Nemereshina,
   Olga/0000-0001-5399-7498; Nikonorova, Eugenia/0000-0002-6360-2194;
   Popova, Elizabeth/0000-0001-6703-4756; Ajsuvakova,
   Olga/0000-0003-4707-9353; Skalny, Anatolij
   Viktorovich/0000-0002-4185-6783
FU Russian Ministry of Education and Science [2014/258-544]
FX The authors would like to thank Prof. Richard A. Anderson for helpful
   discussions and corrections of the manuscript. The current research is
   supported by Russian Ministry of Education and Science within project
   No. 2014/258-544.
CR Abdel-Hamid H A, 2001, J Egypt Public Health Assoc, V76, P53
   Aguado A, 2013, TOXICOL APPL PHARM, V268, P188, DOI 10.1016/j.taap.2013.01.030
   Al-azzawie H.F., 2013, Br. J. Pharmacol. Toxicol., V4, P80
   Al-Saleh I, 2013, BIOL TRACE ELEM RES, V153, P145, DOI 10.1007/s12011-013-9687-7
   Aliaga ME, 2010, J INORG BIOCHEM, V104, P1084, DOI 10.1016/j.jinorgbio.2010.06.006
   Ariza ME, 1998, ENVIRON MOL MUTAGEN, V31, P352, DOI 10.1002/(SICI)1098-2280(1998)31:4<352::AID-EM8>3.3.CO;2-G
   Ayensu Wellington K, 2006, Int J Environ Res Public Health, V3, P141, DOI 10.3390/ijerph2006030018
   Ayotte P, 2011, ENVIRON HEALTH PERSP, V119, P1077, DOI 10.1289/ehp.1003296
   BAGGER S, 1991, J INORG BIOCHEM, V42, P97, DOI 10.1016/0162-0134(91)80036-H
   Baldwin AS, 1996, ANNU REV IMMUNOL, V14, P649, DOI 10.1146/annurev.immunol.14.1.649
   Banhegyi G, 2007, ANN NY ACAD SCI, V1113, P58, DOI 10.1196/annals.1391.007
   Barnes DM, 2005, TOXICOL IN VITRO, V19, P207, DOI 10.1016/j.tiv.2004.08.005
   Barnes DM, 2003, TOXICOL SCI, V75, P368, DOI 10.1093/toxsci/kfg195
   Bashandy SA, 2011, AFR J PHARM PHARMACO, V5, P175
   Basseri S, 2012, BIOCHEM RES INT, V2012, DOI 10.1155/2012/841362
   Bautista Leonelo E, 2009, WMJ, V108, P250
   Beltrán-Sánchez H, 2013, J AM COLL CARDIOL, V62, P697, DOI 10.1016/j.jacc.2013.05.064
   Bender M, 2014, J PUBLIC HEALTH POL, V35, P1, DOI 10.1057/jphp.2013.39
   BENOV LC, 1990, CHEM-BIOL INTERACT, V76, P321, DOI 10.1016/0009-2797(90)90099-9
   Black R S, 1979, Biol Trace Elem Res, V1, P313, DOI 10.1007/BF02778833
   BLOOM GD, 1972, BIOCHEM J, V129, P241, DOI 10.1042/bj1290241
   Bracci M, 2008, IND HEALTH, V46, P567, DOI 10.2486/indhealth.46.567
   Bramanti E, 1999, ANAL BIOCHEM, V274, P163, DOI 10.1006/abio.1999.4257
   Branco V, 2012, FREE RADICAL BIO MED, V52, P781, DOI 10.1016/j.freeradbiomed.2011.12.002
   Brenden N, 2001, CLIN EXP IMMUNOL, V125, P202, DOI 10.1046/j.1365-2249.2001.01580.x
   Cameron AJ, 2004, ENDOCRIN METAB CLIN, V33, P351, DOI 10.1016/j.ecl.2004.03.005
   Carranza-Rosales P, 2005, TOXICOLOGY, V210, P111, DOI 10.1016/j.tox.2005.01.006
   Carvalho CML, 2008, J BIOL CHEM, V283, P11913, DOI 10.1074/jbc.M710133200
   Carvalho CML, 2011, FASEB J, V25, P370, DOI 10.1096/fj.10-157594
   Cave M, 2010, ENVIRON HEALTH PERSP, V118, P1735, DOI 10.1289/ehp.1002720
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Chang JY, 2008, NEUROTOXICOLOGY, V29, P1054, DOI 10.1016/j.neuro.2008.08.003
   Chang JW, 2011, J HAZARD MATER, V185, P749, DOI 10.1016/j.jhazmat.2010.09.084
   Chen CY, 2006, SCI TOTAL ENVIRON, V366, P627, DOI 10.1016/j.scitotenv.2005.12.021
   Chen CY, 2006, ENVIRON HEALTH PERSP, V114, P297, DOI 10.1289/ehp.7861
   Chen CY, 2005, CLIN CHEM, V51, P759, DOI 10.1373/clinchem.2004.042093
   Chen YW, 2006, CHEM RES TOXICOL, V19, P1080, DOI 10.1021/tx0600705
   Chen YW, 2006, DIABETES, V55, P1614, DOI 10.2337/db06-0029
   Chen YW, 2010, TOXICOL APPL PHARM, V243, P323, DOI 10.1016/j.taap.2009.11.024
   Cho S, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-527
   Choi B, 2013, ENVIRON TOXICOL, DOI [10.1002/tox.21899, DOI 10.1002/T0X.21899]
   Cnop M, 2012, TRENDS MOL MED, V18, P59, DOI 10.1016/j.molmed.2011.07.010
   Cotton F., 1999, ADV INORG CHEM, V6 th, P1376
   Cuello S, 2010, FOOD CHEM TOXICOL, V48, P1405, DOI 10.1016/j.fct.2010.03.009
   da Cunha V, 2000, ARCH ENVIRON CON TOX, V39, P124
   Dastych J, 1999, J ALLERGY CLIN IMMUN, V103, P1108, DOI 10.1016/S0091-6749(99)70186-7
   de Freitas AS, 2009, BRAIN RES BULL, V79, P77, DOI 10.1016/j.brainresbull.2008.11.001
   De Vos G., 2004, Journal of Allergy and Clinical Immunology, V113, pS66, DOI 10.1016/j.jaci.2003.12.209
   de Vos G, 2007, IMMUNOPHARM IMMUNOT, V29, P537, DOI 10.1080/08923970701690993
   임신예, 2008, Annals of Occupational and Environmental Medicine, V20, P302
   Drescher O, 2014, J EXPO SCI ENV EPID, V24, P608, DOI 10.1038/jes.2013.96
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   ELIAV E, 1995, PHYS REV A, V52, P2765, DOI 10.1103/PhysRevA.52.2765
   Eom SY, 2014, INT ARCH OCC ENV HEA, V87, P501, DOI 10.1007/s00420-013-0891-8
   EZAKI O, 1989, J BIOL CHEM, V264, P16118
   Farina M, 2004, TOXICOL LETT, V146, P227, DOI 10.1016/j.toxlet.2003.10.001
   Farina M, 2009, TOXICOL SCI, V112, P416, DOI 10.1093/toxsci/kfp219
   Faustman EM, 2002, ENVIRON HEALTH PERSP, V110, P859, DOI 10.1289/ehp.02110s5859
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Fillion Myriam, 2006, Environ Health, V5, P29, DOI 10.1186/1476-069X-5-29
   Franco JL, 2009, FREE RADICAL BIO MED, V47, P449, DOI 10.1016/j.freeradbiomed.2009.05.013
   Friend A, 2013, METAB SYNDR RELAT D, V11, P71, DOI 10.1089/met.2012.0122
   Furieri LB, 2011, BRIT J PHARMACOL, V162, P1819, DOI 10.1111/j.1476-5381.2011.01203.x
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Futatsuka M, 1996, J Epidemiol, V6, P204
   García-Sevillano MA, 2014, ANAL CHIM ACTA, V842, P42, DOI 10.1016/j.aca.2014.07.014
   Gardner RM, 2010, TOXICOL LETT, V198, P182, DOI 10.1016/j.toxlet.2010.06.015
   Gardner RM, 2010, ENVIRON RES, V110, P345, DOI 10.1016/j.envres.2010.02.001
   Gardner RM, 2009, ENVIRON HEALTH PERSP, V117, P1932, DOI 10.1289/ehp.0900855
   GEORGE JM, 1971, ENDOCRINOLOGY, V89, P1489, DOI 10.1210/endo-89-6-1489
   Ghosh R, 2007, CRYSTENGCOMM, V9, P353, DOI 10.1039/b702560b
   Gillespie R.J., 1972, Molecular geometry
   GILLESPIE RJ, 1984, INORG CHEM, V23, P887, DOI 10.1021/ic00175a019
   Goering PL, 1999, TOXICOL LETT, V105, P183, DOI 10.1016/S0378-4274(99)00002-8
   Golpon HA, 2003, TOXICOLOGY, V192, P179, DOI 10.1016/S0300-483X(03)00303-2
   Gradinaru R, 2011, BIOMETALS, V24, P1115, DOI 10.1007/s10534-011-9472-z
   GRDENIC D, 1965, Q REV CHEM SOC, V19, P303, DOI 10.1039/qr9651900303
   Greenwood N.N., 2012, Chemistry of the Elements
   Grotto D, 2010, SCI TOTAL ENVIRON, V408, P806, DOI 10.1016/j.scitotenv.2009.10.053
   Gump BB, 2012, ENVIRON RES, V112, P204, DOI 10.1016/j.envres.2011.10.002
   Hagele TJ, 2007, INT J TOXICOL, V26, P57, DOI 10.1080/10915810601120509
   Hansen JM, 2006, FREE RADICAL BIO MED, V40, P138, DOI 10.1016/j.freeradbiomed.2005.09.023
   He K, 2013, DIABETES CARE, V36, P1584, DOI 10.2337/dc12-1842
   He X, 2013, HYPERTENSION, V62, pA479
   Hemdan NYA, 2007, CLIN EXP IMMUNOL, V148, P325, DOI 10.1111/j.1365-2249.2007.03338.x
   Hijova E, 2005, Bratisl Lek Listy, V106, P248
   HIROTA Y, 1980, TOXICOL APPL PHARM, V53, P174, DOI 10.1016/0041-008X(80)90394-4
   HOFFMAN M, 1980, FEBS LETT, V121, P352, DOI 10.1016/0014-5793(80)80379-6
   Holmgren A, 2010, BIOCHEM BIOPH RES CO, V396, P120, DOI 10.1016/j.bbrc.2010.03.083
   Hong D, 2013, ENVIRON TOXICOL PHAR, V36, P103, DOI 10.1016/j.etap.2013.03.007
   Hu H, 1997, IMMUNOLOGY, V90, P198, DOI 10.1046/j.1365-2567.1997.00145.x
   Huang YL, 1996, BIOL TRACE ELEM RES, V52, P193, DOI 10.1007/BF02789461
   Ibrahim M, 2011, DIABETOLOGIA, V54, pS227
   Jaiswal N, 2013, PLANTA MED, V79, P1145
   James SJ, 2005, NEUROTOXICOLOGY, V26, P1, DOI 10.1016/j.neuro.2004.07.012
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Kawakami T, 2012, TOXICOL APPL PHARM, V258, P32, DOI 10.1016/j.taap.2011.10.004
   Keizo W, 1979, TOXICOL LETT, V4, P49
   Kempuraj D, 2010, J NEUROINFLAMM, V7, DOI 10.1186/1742-2094-7-20
   Kim SH, 2005, IMMUNOPHARM IMMUNOT, V27, P123, DOI 10.1081/IPH-200051757
   Kim SH, 2003, ARCH TOXICOL, V77, P613, DOI 10.1007/s00204-003-0497-0
   Kim SH, 2002, NITRIC OXIDE-BIOL CH, V7, P67, DOI 10.1016/S1089-8603(02)00008-3
   Kitamura M, 2010, BIOMETALS, V23, P941, DOI 10.1007/s10534-010-9296-2
   Kobal AB, 2003, J TRACE ELEM MED BIO, V17, P261
   Kobal AB, 2008, ENVIRON RES, V107, P115, DOI 10.1016/j.envres.2007.07.001
   Kondo T, 2011, EUR J CARDIOV PREV R, V18, P574, DOI 10.1177/1741826710389529
   Kumagai Y, 1997, APPL ORGANOMET CHEM, V11, P635
   Kumagai Y, 1997, J TOXICOL SCI, V22, P372
   KUNKELY H, 1989, CHEM PHYS LETT, V164, P621, DOI 10.1016/0009-2614(89)85270-4
   Kuo CC, 2013, CURR DIABETES REP, V13, P831, DOI 10.1007/s11892-013-0432-6
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lamborg CH, 2014, NATURE, V512, P65, DOI 10.1038/nature13563
   Lee AS, 2005, METHODS, V35, P373, DOI 10.1016/j.ymeth.2004.10.010
   Lee BK, 2013, AM J IND MED, V56, P682, DOI 10.1002/ajim.22107
   강대원, 2013, Journal of Obesity & Metabolic Syndrome, V22, P237
   Lee YW, 2001, NEUROCHEM RES, V26, P1187, DOI 10.1023/A:1013955020515
   Lin TH, 1996, BIOL TRACE ELEM RES, V54, P33, DOI 10.1007/BF02785318
   Lind PM, 2013, ENVIRON INT, V55, P1, DOI 10.1016/j.envint.2013.01.017
   LISON D, 1988, TOXICOL LETT, V40, P29, DOI 10.1016/0378-4274(88)90180-4
   Liu H, 2010, EYE, V24, P137, DOI 10.1038/eye.2009.20
   Liu J, 2003, TOXICOL SCI, V74, P174, DOI 10.1093/toxsci/kfg091
   Liu SH, 2002, J TOXICOL ENV HEAL A, V65, P317, DOI 10.1080/15287390252800891
   Lund BO, 1991, BIOCHEM PHARMACOL, V42, P81
   Machado AC, 2007, ENVIRON TOXICOL PHAR, V24, P92, DOI 10.1016/j.etap.2007.02.005
   Mackness M, 2004, FREE RADICAL BIO MED, V37, P1317, DOI 10.1016/j.freeradbiomed.2004.07.034
   Mah V, 2010, CHEM RES TOXICOL, V23, P1815, DOI 10.1021/tx100260e
   Mahboob M, 2001, J ENVIRON SCI HEAL B, V36, P687, DOI 10.1081/PFC-100106195
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Matsuda M, 2013, OBES RES CLIN PRACT, V7, pE330, DOI 10.1016/j.orcp.2013.05.004
   Matsuzawa-Nagata N, 2008, METABOLISM, V57, P1071, DOI 10.1016/j.metabol.2008.03.010
   Mazerik JN, 2007, TOXICOL MECH METHOD, V17, P541, DOI 10.1080/15376510701380505
   Barcelos GRM, 2011, ARCH TOXICOL, V85, P1151, DOI 10.1007/s00204-011-0652-y
   MCCORD JM, 1969, J BIOL CHEM, V244, P6049
   MELTZER HM, 1994, BIOL TRACE ELEM RES, V46, P135, DOI 10.1007/BF02790074
   Merzoug S., 2009, J. Cell Animal Biol, V3, P222
   Milaeva E, 2004, BIOINORG CHEM APPL, V2, P69, DOI 10.1155/S1565363304000068
   MILLER DM, 1993, CHEM-BIOL INTERACT, V88, P23, DOI 10.1016/0009-2797(93)90082-A
   Moon SS, 2013, DIABETIC MED, V30, pe143, DOI 10.1111/dme.12103
   Moon SS, 2014, ENDOCRINE, V46, P263, DOI 10.1007/s12020-013-0061-5
   Moreira EL, 2012, TOXICOL SCI, V130, P373, DOI 10.1093/toxsci/kfs252
   Mozaffarian D, 2012, HYPERTENSION, V60, P645, DOI 10.1161/HYPERTENSIONAHA.112.196154
   Mozumdar A, 2011, DIABETES CARE, V34, P216, DOI 10.2337/dc10-0879
   MYKKANEN HM, 1974, B ENVIRON CONTAM TOX, V12, P10, DOI 10.1007/BF01713020
   NAKAGAWA R, 1995, CHEMOSPHERE, V30, P135, DOI 10.1016/0045-6535(94)00383-6
   NASU T, 1984, GEN PHARMACOL-VASC S, V15, P247, DOI 10.1016/0306-3623(84)90168-X
   Ni MW, 2010, TOXICOL SCI, V116, P590, DOI 10.1093/toxsci/kfq126
   Nyland JF, 2011, ENVIRON HEALTH PERSP, V119, P1733, DOI 10.1289/ehp.1103741
   Oda E, 2012, ACTA DIABETOL, V49, P89, DOI 10.1007/s00592-011-0309-6
   Omanwar S, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/530603
   Oram PD, 1996, CHEM RES TOXICOL, V9, P709, DOI 10.1021/tx9501896
   Ou YC, 1997, TOXICOL APPL PHARM, V147, P31, DOI 10.1006/taap.1997.8235
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Pal S, 2013, DIABETES METAB, V39, P497, DOI 10.1016/j.diabet.2013.01.006
   Parikh Rakesh M, 2012, Indian J Endocrinol Metab, V16, P7, DOI 10.4103/2230-8210.91175
   Park HJ, 2013, TOXICOL IND HEALTH, V29, P169, DOI 10.1177/0748233711427048
   Park SB, 2009, BIOL TRACE ELEM RES, V130, P218, DOI 10.1007/s12011-009-8336-7
   Park SK, 2013, ENVIRON RES, V123, P25, DOI 10.1016/j.envres.2013.02.003
   Park S, 2013, BIOL TRACE ELEM RES, V151, P315, DOI 10.1007/s12011-012-9566-7
   PEARSON RG, 1963, J AM CHEM SOC, V85, P3533, DOI 10.1021/ja00905a001
   PEARSON RG, 1968, J CHEM EDUC, V45, P581, DOI 10.1021/ed045p581
   Pecanha FM, 2010, J PHYSIOL PHARMACOL, V61, P29
   Pedersen EB, 2005, AM J HYPERTENS, V18, P612, DOI 10.1016/j.amjhyper.2004.11.022
   Peltz A, 2009, INT J TOXICOL, V28, P190, DOI 10.1177/1091581809338077
   PerrinNadif R, 1996, J TOXICOL ENV HEALTH, V48, P107, DOI 10.1080/009841096161366
   Pillarisetti S, 2004, EXPERT OPIN THER TAR, V8, P401, DOI 10.1517/14728222.8.5.401
   Pinheiro MCN, 2008, ENVIRON RES, V107, P53, DOI 10.1016/j.envres.2007.08.007
   Pollack AZ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0092152
   Pollack AZ, 2012, AM J EPIDEMIOL, V175, P645, DOI 10.1093/aje/kwr375
   Pollard KM, 2001, INT IMMUNOPHARMACOL, V1, P581, DOI 10.1016/S1567-5769(00)00034-5
   PORRAS AG, 1981, J BIOL CHEM, V256, P9096
   Qian YC, 2003, NEUROCHEM RES, V28, P153, DOI 10.1023/A:1021664632393
   Qian YC, 2001, NEUROTOX RES, V3, P581, DOI 10.1007/BF03033212
   Queiroz MLD, 1998, HUM EXP TOXICOL, V17, P225
   Ravichandran M, 2004, CHEMOSPHERE, V55, P319, DOI 10.1016/j.chemosphere.2003.11.011
   REAVEN GM, 1993, ANNU REV MED, V44, P121, DOI 10.1146/annurev.med.44.1.121
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   RIBAROV S, 1982, EXPERIENTIA, V38, P1354, DOI 10.1007/BF01954948
   RIBAROV SR, 1983, CHEM-BIOL INTERACT, V45, P105, DOI 10.1016/0009-2797(83)90046-7
   Risher JF, 2002, TOXICOL IND HEALTH, V18, P109, DOI 10.1191/0748233702th138oa
   Rizzetti DA, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055806
   Rizzo M, 2009, TRANSL RES, V153, P217, DOI 10.1016/j.trsl.2009.01.008
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Flores CR, 2011, DIABETES RES CLIN PR, V91, P333, DOI 10.1016/j.diabres.2010.12.014
   Romeo GR, 2012, ARTERIOSCL THROM VAS, V32, P1771, DOI 10.1161/ATVBAHA.111.241869
   Rossoni LV, 1999, BRAZ J MED BIOL RES, V32, P989, DOI 10.1590/S0100-879X1999000800009
   Rumbeiha WK, 1998, TOXICOL LETT, V95, P169
   Sage AT, 2012, OBESITY, V20, P748, DOI 10.1038/oby.2011.144
   Salonen JT, 2000, ATHEROSCLEROSIS, V148, P265, DOI 10.1016/S0021-9150(99)00272-5
   Santos CXC, 2014, ANTIOXID REDOX SIGN, V20, P121, DOI 10.1089/ars.2013.5262
   SARAFIAN TA, 1994, TOXICOL LETT, V74, P149, DOI 10.1016/0378-4274(94)90093-0
   Shanker G, 2004, MOL BRAIN RES, V128, P48, DOI 10.1016/j.molbrainres.2004.05.022
   Sharma SK, 2008, BIOCHEM BIOPH RES CO, V372, P341, DOI 10.1016/j.bbrc.2008.05.052
   Shimojo N, 1996, ENVIRON TOXICOL PHAR, V2, P35, DOI 10.1016/1382-6689(96)00025-7
   SHINADA M, 1990, CHEMOSPHERE, V21, P57, DOI 10.1016/0045-6535(90)90378-7
   Sidorenkov O, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-582
   Sies H, 1997, EXP PHYSIOL, V82, P291, DOI 10.1113/expphysiol.1997.sp004024
   SIN WC, 1989, B ENVIRON CONTAM TOX, V42, P942
   Skalnaya MG, 2007, J TRACE ELEM MED BIO, V21, P59, DOI 10.1016/j.jtemb.2007.09.019
   Skalnaya MG, 2014, BIOL TRACE ELEM RES, V161, P13, DOI 10.1007/s12011-014-0082-9
   SOLOMON HS, 1975, AM J PHYSIOL, V229, P8, DOI 10.1152/ajplegacy.1975.229.1.8
   Sorg O, 1998, ACTA NEUROPATHOL, V96, P621, DOI 10.1007/s004010050943
   Sponder M, 2014, VASC HEALTH RISK MAN, V10, P311, DOI 10.2147/VHRM.S61510
   Stacchiotti A, 2009, FOOD CHEM TOXICOL, V47, P2834, DOI 10.1016/j.fct.2009.09.003
   Stacchiotti A, 2009, TOXICOLOGY, V264, P215, DOI 10.1016/j.tox.2009.08.014
   Stringari J, 2008, TOXICOL APPL PHARM, V227, P147, DOI 10.1016/j.taap.2007.10.010
   Syversen T, 2012, J TRACE ELEM MED BIO, V26, P215, DOI 10.1016/j.jtemb.2012.02.004
   Taher M, 2000, J RES MED SCI, V5, P38
   Takahashi H, 2000, J TRACE ELEM EXP MED, V13, P227, DOI 10.1002/(SICI)1520-670X(2000)13:2<227::AID-JTRA6>3.0.CO;2-F
   Tinkov AA, 2014, BIOL TRACE ELEM RES, V161, P255, DOI 10.1007/s12011-014-0124-3
   TOMERA JF, 1986, ARCH INT PHARMACOD T, V283, P295
   Torres AD, 2000, PEDIATRICS, V105, DOI 10.1542/peds.105.3.e34
   Tunali-Akbay T, 2007, PHYTOTHER RES, V21, P26, DOI 10.1002/ptr.2007
   Usuki F, 2008, NEUROTOXICOLOGY, V29, P22, DOI 10.1016/j.neuro.2007.08.011
   Usuki F, 2013, SCI REP-UK, V3, DOI 10.1038/srep02346
   Usuki F, 2011, J BIOL CHEM, V286, P6641, DOI 10.1074/jbc.M110.168872
   Valera B, 2009, HYPERTENSION, V54, P981, DOI 10.1161/HYPERTENSIONAHA.109.135046
   Valko M, 2005, CURR MED CHEM, V12, P1161, DOI 10.2174/0929867053764635
   VANDERLINDEN WE, 1974, ANAL CHIM ACTA, V68, P143, DOI 10.1016/S0003-2670(01)85155-2
   Vanni E, 2010, DIGEST LIVER DIS, V42, P320, DOI 10.1016/j.dld.2010.01.016
   Vaziri ND, 2006, NAT CLIN PRACT NEPHR, V2, P582, DOI 10.1038/ncpneph0283
   Villanueva MBG, 2000, J HEALTH SCI, V46, P358
   Vupputuri S, 2005, ENVIRON RES, V97, P195, DOI 10.1016/j.envres.2004.05.001
   WADA O, 1976, ENVIRON RES, V12, P75, DOI 10.1016/0013-9351(76)90010-4
   Wagner C, 2010, BIOMETALS, V23, P1171, DOI 10.1007/s10534-010-9367-4
   Walczak-Drzewiecka A, 2005, INT ARCH ALLERGY IMM, V136, P181, DOI 10.1159/000083892
   Wataha JC, 2008, DENT MATER, V24, P765, DOI 10.1016/j.dental.2007.09.002
   Watanabe C, 1999, TOHOKU J EXP MED, V187, P121, DOI 10.1620/tjem.187.121
   Wiggers GA, 2008, AM J PHYSIOL-HEART C, V295, pH1033, DOI 10.1152/ajpheart.00430.2008
   Wiggers GA, 2008, COMP BIOCHEM PHYS C, V147, P252, DOI 10.1016/j.cbpc.2007.10.003
   Wolf MB, 2007, BIOMETALS, V20, P73, DOI 10.1007/s10534-006-9016-0
   WOODS JS, 1995, BIOCHEM PHARMACOL, V50, P1719, DOI 10.1016/0006-2952(95)02075-6
   Wössmann W, 1999, ARCH DIS CHILD, V80, P556
   Wu Z, 2001, INT IMMUNOL, V13, P297, DOI 10.1093/intimm/13.3.297
   Xia Z., 2012, ACTA NEUROPHARMACOLO, V2, P33
   Yasutake A, 1997, TOHOKU J EXP MED, V182, P185, DOI 10.1620/tjem.182.185
   Yin ZB, 2007, BRAIN RES, V1131, P1, DOI 10.1016/j.brainres.2006.10.070
   YONAHA M, 1983, LIFE SCI, V32, P1507, DOI 10.1016/0024-3205(83)90917-7
   Yoshizawa K, 2002, NEW ENGL J MED, V347, P1755, DOI 10.1056/NEJMoa021437
   You Chang-Hun, 2011, J Prev Med Public Health, V44, P218, DOI 10.3961/jpmph.2011.44.5.218
   Youn JY, 2014, DIABETES, V63, P2344, DOI 10.2337/db13-0719
   Young CN, 2012, J CLIN INVEST, V122, P3960, DOI 10.1172/JCI64583
   Zabinski Z, 2000, TOXICOL IND HEALTH, V16, P58, DOI 10.1191/074823300678827663
   Zahir F, 2006, INDIAN J CLIN BIOCHE, V21, P149, DOI 10.1007/BF02912931
   Zalba G, 2001, HYPERTENSION, V38, P1395, DOI 10.1161/hy1201.099611
   ZDOLSEK JM, 1994, IMMUNOPHARMACOLOGY, V28, P201, DOI 10.1016/0162-3109(94)90055-8
   Zefferino R, 2006, Int J Immunopathol Pharmacol, V19, P15
   Zhang KZ, 2008, NATURE, V454, P455, DOI 10.1038/nature07203
   Zhang SC, 2009, OBESITY, V17, P1581, DOI 10.1038/oby.2009.125
   Zhang Y, 2013, DOSE-RESPONSE, V11, P109, DOI 10.2203/dose-response.11-055.Rongzhu
   Zhang Ye, 2010, Wei Sheng Yan Jiu, V39, P271
NR 250
TC 89
Z9 93
U1 1
U2 79
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0966-0844
EI 1572-8773
J9 BIOMETALS
JI Biometals
PD APR
PY 2015
VL 28
IS 2
BP 231
EP 254
DI 10.1007/s10534-015-9823-2
PG 24
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CE3RE
UT WOS:000351745200001
PM 25633799
DA 2025-06-11
ER

PT J
AU Choi, M
   Park, S
   Lee, M
AF Choi, Munji
   Park, Seongmin
   Lee, Myoungsook
TI L-Carnitine's Effect on the Biomarkers of Metabolic Syndrome: A
   Systematic Review and Meta-Analysis of Randomized Controlled Trials
SO NUTRIENTS
LA English
DT Review
DE L-carnitine; metabolic syndrome; waist circumference; blood pressure;
   fasting blood sugar; triglyceride; HDL-cholesterol
ID INSULIN-RESISTANCE; MAINTENANCE HEMODIALYSIS; OXIDATIVE STRESS; LIPID
   PROFILE; WEIGHT-LOSS; SUPPLEMENTATION; ASSOCIATION; SENSITIVITY; ADULTS;
   WOMEN
AB A systematic review and meta-analysis of randomized controlled trials (RCTs) was carried out to assess L-carnitine supplements' influence on the biomarkers of metabolic syndrome (MetSyn). PubMed, EMBASE, Cochrane library, and CINAHL were used to collect RCT studies published prior to February 2020. RCT studies were included if they had at least one of the following biomarker outcome measurements: waist circumference (WC), blood pressure (BP), fasting blood sugar (FBS), triglyceride (TG), or high density lipoprotein-cholesterol (HDLc). Nine of twenty studies with adequate methodological quality were included in this meta-analysis. The dose of L-carnitine supplementation administered varied between 0.75 and 3 g/day for durations of 8-24 weeks. L-carnitine supplementation significantly reduced WC and systolic BP (SBP), with no significant effects on FBS, TG, and HDLc. We found that L-carnitine supplementation at a dose of more than 1 g/d significantly reduced FBS and TG and increased HDLc. In conclusion, L-carnitine supplementation is correlated with a significant reduction of WC and BP. A dose of 1-3 g/d could improve the biomarkers of MetSyn by reducing FBS and TG and increasing HDLc.
C1 [Choi, Munji; Park, Seongmin; Lee, Myoungsook] Sungshin Womens Univ, Dept Food & Nutr, Seoul 01133, South Korea.
   [Choi, Munji; Park, Seongmin; Lee, Myoungsook] Sungshin Womens Univ, Res Inst Obes Sci, Seoul 01133, South Korea.
   [Park, Seongmin] Gyeongin Reg Korea Food & Drug Adm, Ctr Food & Drug Anal, Incheon 402835, South Korea.
C3 Sungshin Women's University; Sungshin Women's University
RP Lee, M (corresponding author), Sungshin Womens Univ, Dept Food & Nutr, Seoul 01133, South Korea.; Lee, M (corresponding author), Sungshin Womens Univ, Res Inst Obes Sci, Seoul 01133, South Korea.
EM mjchoi@nfsi.or.kr; kpsm3003@korea.kr; mlee@sungshin.ac.kr
OI Lee, Myoungsook/0000-0003-1344-6979
FU National Research Foundation of Korea (NRF) - Korea Government (MSIP)
   [2019R1A2C1008434]
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korea Government (MSIP; 2019R1A2C1008434).
CR Amiri-Moghadam S, 2015, CURR TOP NUTRACEUT R, V13, P71
   [Anonymous], 2016, J Gastroenterol Hepatol Res
   [Anonymous], REC DIET ALL
   Askarpour M, 2019, J HUM HYPERTENS, V33, P725, DOI 10.1038/s41371-019-0248-1
   BARTEL LL, 1981, AM J CLIN NUTR, V34, P1314, DOI 10.1093/ajcn/34.7.1314
   Bruzell E., 2015, RISK ASSESSMENT OTHE
   González-Ortiz M, 2008, ANN NUTR METAB, V52, P335, DOI 10.1159/000151488
   Grundy SM, 2004, ARTERIOSCL THROM VAS, V24, pE13, DOI 10.1161/01.ATV.0000111245.75752.C6
   Guo J, 2018, CLIN EXP HYPERTENS, V40, P476, DOI 10.1080/10641963.2017.1403619
   Harmeyer J., 2002, Lohmann Information, P15
   Hathcock JN, 2006, REGUL TOXICOL PHARM, V46, P23, DOI 10.1016/j.yrtph.2006.06.007
   Higgins JP, 2011, BMJ, V343, pd5928, DOI [DOI 10.1136/BMJ.D5928, 10.1136/bmj.d5928.22008217]
   Hurot JM, 2002, J AM SOC NEPHROL, V13, DOI 10.1681/ASN.V133708
   Katz Arnold M., 1998, Cardiology Clinics, V16, P633, DOI 10.1016/S0733-8651(05)70040-0
   Koeth RA, 2013, NAT MED, V19, P576, DOI 10.1038/nm.3145
   Kudoh Y, 2013, CARDIORENAL MED, V3, P200, DOI 10.1159/000355016
   Liang Y, 1998, Asia Pac J Clin Nutr, V7, P192
   Mahdavi AM, 2018, PROG NUTR, V20, P337, DOI 10.23751/pn.v20i1-S.6120
   Malaguarnera M, 2010, AM J GASTROENTEROL, V105, P1338, DOI 10.1038/ajg.2009.719
   Malaguarnera M, 2009, AM J CLIN NUTR, V89, P71, DOI 10.3945/ajcn.2008.26251
   Mandaui AM, 2015, NUTR RES, V35, P707, DOI 10.1016/j.nutres.2015.06.003
   Mingrone G, 2004, ANN NY ACAD SCI, V1033, P99, DOI 10.1196/annals.1320.009
   Muoio DM, 2012, CELL METAB, V15, P764, DOI 10.1016/j.cmet.2012.04.005
   Naini AE, 2012, J NUTR METAB, V2012, DOI 10.1155/2012/510483
   Otun J, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-40647-x
   Pekala J, 2011, CURR DRUG METAB, V12, P667, DOI 10.2174/138920011796504536
   Pooyandjoo M, 2016, OBES REV, V17, P970, DOI 10.1111/obr.12436
   Rajasekar P, 2007, CLIN EXP HYPERTENS, V29, P517, DOI 10.1080/10641960701743998
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Ringseis R, 2012, EUR J NUTR, V51, P1, DOI 10.1007/s00394-011-0284-2
   Ruggenenti P, 2009, HYPERTENSION, V54, P567, DOI 10.1161/HYPERTENSIONAHA.109.132522
   Serban MC, 2016, SCI REP-UK, V6, DOI 10.1038/srep19188
   Talenezhad N, 2020, CLIN NUTR ESPEN, V37, P9, DOI 10.1016/j.clnesp.2020.03.008
   Vidal-Casariego A, 2013, EXP CLIN ENDOCR DIAB, V121, P234, DOI 10.1055/s-0033-1333688
   Wu XY, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.118.009585
   Yang SK, 2014, J NEPHROL, V27, P317, DOI 10.1007/s40620-013-0002-7
NR 36
TC 12
Z9 12
U1 1
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2020
VL 12
IS 9
AR 2795
DI 10.3390/nu12092795
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OH3FF
UT WOS:000582453200001
PM 32932644
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pla-Pagà, L
   Guirro, M
   Gual-Grau, A
   Gibert-Ramos, A
   Foguet-Romero, E
   Catalan, U
   Mayneris-Perxachs, J
   Canela, N
   Valls, RM
   Arola, L
   Solà, R
   Pedret, A
AF Pla-Paga, Laura
   Guirro, Maria
   Gual-Grau, Andreu
   Gibert-Ramos, Albert
   Foguet-Romero, Elisabet
   Catalan, Ursula
   Mayneris-Perxachs, Jordi
   Canela, Nuria
   Valls, Rosa M.
   Arola, Lluis
   Sola, Rosa
   Pedret, Anna
TI Proteomic Analysis of Heart and Kidney Tissues in Healthy and Metabolic
   Syndrome Rats after Hesperidin Supplementation
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE hesperidin; kidneys; metabolic syndrome; proteomics
ID BLOOD-PRESSURE; EXPRESSION; DISEASE; PROTEIN; STRESS; FAMILY; CELLS;
   CD2AP; MICE
AB Scope Proteomics has provided new strategies to elucidate the mechanistic action of hesperidin, a flavonoid present in citrus fruits. Thus, the aim of the present study is to determine the effects of hesperidin supplementation (HS) on the proteomic profiles of heart and kidney tissue samples from healthy and metabolic syndrome (MS) rats.
   Methods and results 24 Sprague Dawley rats are randomized into four groups: healthy rats fed with a standard diet without HS, healthy rats administered with HS (100 mg kg(-1) day(-1)), MS rats without HS, and MS rats administered with HS (100 mg kg(-1) day(-1)) for eight weeks. Heart and kidney samples are obtained, and proteomic analysis is performed by mass spectrometry. Multivariate, univariate, and ingenuity pathways analyses are performed. Comparative and semiquantitative proteomic analyses of heart and kidney tissues reveal differential protein expression between MS rats with and without HS. The top diseases and functions implicated are related to the cardiovascular system, free radical scavenging, lipid metabolism, glucose metabolism, and renal and urological diseases.
   Conclusion This study is the first to demonstrate the protective capacity of hesperidin to change to the proteomic profiles in relation to different cardiovascular risk biomarkers in the heart and kidney tissues of MS rats.
C1 [Pla-Paga, Laura; Valls, Rosa M.; Arola, Lluis; Sola, Rosa; Pedret, Anna] Eurecat, Ctr Tecnol Catalunya, Unitat Nutr & Salut, Av Univ 1, Reus 43204, Spain.
   [Pla-Paga, Laura; Catalan, Ursula; Valls, Rosa M.; Sola, Rosa; Pedret, Anna] Univ Rovira & Virgili, Fac Med & Ciencies Salut Funct Nutr, Oxidat & Cardiovasc Dis Grp NFOC SALUT, C St Llorenc 21, Reus 43201, Spain.
   [Guirro, Maria; Gual-Grau, Andreu; Gibert-Ramos, Albert; Arola, Lluis] Univ Rovira & Virgili, Dept Biochem & Biotechnol, Nutrigen Res Grp, C Marcelli Domingo 1, Tarragona 43007, Spain.
   [Guirro, Maria; Foguet-Romero, Elisabet; Mayneris-Perxachs, Jordi] Univ Rovira & Virgili, EURECAT Ctr Tecnol Catalunya Unique Sci & Tech In, Joint Unit, Ctr Omic Sci, Av Univ 1, Reus 43204, Spain.
   [Catalan, Ursula; Canela, Nuria] Inst Invest Sanitaria Pere Virgili, Av Univ 1, Reus 43204, Spain.
   [Sola, Rosa] Hosp Univ ST Joan, Av Doctor Josep Laporte 2, Reus 43204, Spain.
C3 Universitat Rovira i Virgili; Universitat Rovira i Virgili; Universitat
   Rovira i Virgili; Universitat Rovira i Virgili; Institut d'Investigacio
   Sanitaria Pere Virgili (IISPV)
RP Valls, RM (corresponding author), Univ Rovira & Virgili, Fac Med & Ciencies Salut Funct Nutr, Oxidat & Cardiovasc Dis Grp NFOC SALUT, C St Llorenc 21, Reus 43201, Spain.; Mayneris-Perxachs, J (corresponding author), Univ Rovira & Virgili, EURECAT Ctr Tecnol Catalunya Unique Sci & Tech In, Joint Unit, Ctr Omic Sci, Av Univ 1, Reus 43204, Spain.
EM jmayneris@idibgi.org; rosamaria.valls@urv.cat
RI SOLÀ, Rosa/N-5919-2014; Valls, Rosa/AAB-1163-2019; Mayneris-Perxachs,
   Jordi/AAG-7724-2020; Pla, Laura/Z-6252-2019; Canela, Núria/I-5401-2015;
   Arola, Lluis/C-6074-2011; MAYNERIS-PERXACHS, JORDI/B-2589-2018; Catalan,
   Ursula/N-5712-2014; Gibert Ramos, Albert/F-4438-2017
OI Valls, Rosa Maria/0000-0002-3351-0942; Gual-Grau,
   Andreu/0000-0002-8901-3582; PLA PAGA, LAURA/0000-0003-3033-6691; Arola,
   Lluis/0000-0003-2767-1974; MAYNERIS-PERXACHS, JORDI/0000-0003-3788-3815;
   Catalan, Ursula/0000-0001-8884-9823; Gibert Ramos,
   Albert/0000-0002-5987-1164
FU 7th Framework Program of the European Union; Agency for Business
   Competitiveness of the Government of Catalonia (ACCI) under the
   TECNOspring program [TECSPR14-2-0001]; Estrategic de Recerca i Innovacio
   en Salut postdoctoral grant (Catalunya, Spain) [SLT0021/16/00239]
FX L.A., R.S., and A.P. contributed equally to this work. This research was
   co-funded by the 7th Framework Program of the European Union and the
   Agency for Business Competitiveness of the Government of Catalonia
   (ACCI) under the TECNOspring program awarded to JM-P (TECSPR14-2-0001).
   A.P. has a Torres Quevedo contract (Subprograma Estatal de
   Incorporacion, Plan Estatal de Investigacion Cientifica y Tecnica y de
   Innovacion). U.C. has a Pla Estrategic de Recerca i Innovacio en Salut
   postdoctoral grant (SLT0021/16/00239); Catalunya, Spain).
CR Alissa EM, 2017, CRIT REV FOOD SCI, V57, P1950, DOI 10.1080/10408398.2015.1040487
   Brocker C, 2011, CHEM-BIOL INTERACT, V191, P269, DOI 10.1016/j.cbi.2011.02.016
   Catalán U, 2016, MOL NUTR FOOD RES, V60, P2114, DOI 10.1002/mnfr.201600052
   Chaves DFS, 2017, J PROTEOME RES, V16, P4086, DOI 10.1021/acs.jproteome.7b00476
   Chen A, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01318
   Cui ZY, 2011, AM J CARDIOVASC DIS, V1, P274
   Dobias L, 2016, PHYTOTHER RES, V30, P1665, DOI 10.1002/ptr.5670
   de Oliveira JMPF, 2020, PHYTOMEDICINE, V73, DOI 10.1016/j.phymed.2019.152887
   Gandhi PU, 2016, JACC-HEART FAIL, V4, P860, DOI 10.1016/j.jchf.2016.08.002
   Gao F, 2016, OPEN BIOL, V6, DOI 10.1098/rsob.150256
   Guirro M, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9010079
   Guirro M, 2018, ELECTROPHORESIS, V39, P1692, DOI 10.1002/elps.201700476
   He T, 2015, HERZ, V40, P783, DOI 10.1007/s00059-015-4301-8
   Homayouni F, 2018, PHYTOTHER RES, V32, P1073, DOI 10.1002/ptr.6046
   Huber TB, 2003, MOL CELL BIOL, V23, P4917, DOI 10.1128/MCB.23.14.4917-4928.2003
   Hyvönen ME, 2013, ACTA DIABETOL, V50, P887, DOI 10.1007/s00592-013-0475-9
   Iskender H, 2017, BIOMED PHARMACOTHER, V90, P500, DOI 10.1016/j.biopha.2017.03.102
   Jain M, 2018, EMBO J, V37, DOI 10.15252/embj.201694813
   Lerma-García MJ, 2016, FOOD CHEM, V196, P739, DOI 10.1016/j.foodchem.2015.10.009
   Jia S, 2015, FOOD FUNCT, V6, P878, DOI 10.1039/c4fo00993b
   Kobayashi K, 2004, J HYPERTENS, V22, P1723, DOI 10.1097/00004872-200409000-00016
   Kohan AB, 2013, AM J PHYSIOL-GASTR L, V304, pG1128, DOI 10.1152/ajpgi.00409.2012
   Maneesai P, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101549
   Mokou M, 2017, EXPERT REV PROTEOMIC, V14, P117, DOI 10.1080/14789450.2017.1274653
   Mosqueda-Solís A, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-32875-4
   Nakanishi T., 2016, Etiology and morphogenesis of congenital heart disease: From gene function and cellular interaction to morphology
   Negre-Salvayre A, 2010, FREE RADICAL RES, V44, P1125, DOI 10.3109/10715762.2010.498478
   Nohr MK, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0159747
   Osanai T, 2003, J HYPERTENS, V21, P2323, DOI 10.1097/00004872-200312000-00021
   Palmieri F, 2013, MOL ASPECTS MED, V34, P465, DOI 10.1016/j.mam.2012.05.005
   Park ER, 2017, CANCER MED-US, V6, P749, DOI 10.1002/cam4.1042
   Pedret A, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0129160
   Pinkaew D, 2017, ADV CLIN CHEM, V82, P265, DOI 10.1016/bs.acc.2017.06.006
   Pritchard TJ, 2007, AM J PHYSIOL-HEART C, V293, pH1172, DOI 10.1152/ajpheart.00279.2007
   Ramirez CE, 2014, PROSTAG OTH LIPID M, V113, P38, DOI 10.1016/j.prostaglandins.2014.08.001
   Rangel-Huerta OD, 2015, J NUTR, V145, P1808, DOI 10.3945/jn.115.213660
   Reagan-Shaw S, 2008, FASEB J, V22, P659, DOI 10.1096/fj.07-9574LSF
   Rienks J, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040415
   Serino A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010053
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Sun YZ, 2017, EUR J PHARMACOL, V815, P109, DOI 10.1016/j.ejphar.2017.09.010
   Toomer K, 2019, ANAT REC, V302, P117, DOI 10.1002/ar.23911
   VerHague MA, 2013, ARTERIOSCL THROM VAS, V33, P2501, DOI 10.1161/ATVBAHA.113.301948
   Wang JH, 2017, BMC GENOMICS, V18, DOI [10.1186/s12864-017-4377-z, 10.1186/s12864-017-4366-2]
   Wei Q, 2010, CANCER RES, V70, P2942, DOI 10.1158/0008-5472.CAN-09-3826
   World Health Organisation, 2018, TOP 10 CAUS DEATH
   Wunpathe C, 2018, AM J CHINESE MED, V46, P751, DOI [10.1142/s0192415x18500398, 10.1142/S0192415X18500398]
   Yamamoto M, 2013, FOOD FUNCT, V4, P1346, DOI 10.1039/c3fo60030k
   Yumnam S, 2017, MOL MED REP, V16, P5386, DOI 10.3892/mmr.2017.7232
   Zhao CN, 2017, NUTRIENTS, V9, DOI 10.3390/nu9060598
   Zhao J, 2017, ONCOL LETT, V14, P5569, DOI 10.3892/ol.2017.6873
NR 51
TC 7
Z9 7
U1 1
U2 29
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD MAY
PY 2020
VL 64
IS 10
AR 1901063
DI 10.1002/mnfr.201901063
EA MAY 2020
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA LT1QK
UT WOS:000530567900001
PM 32281714
DA 2025-06-11
ER

PT J
AU Barnes, TRE
   Paton, C
   Cavanagh, MR
   Hancock, E
   Taylor, DM
AF Barnes, Thomas R. E.
   Paton, Carol
   Cavanagh, Mary-Rose
   Hancock, Elizabeth
   Taylor, David M.
CA UK Prescribing Observ Mental Hlth
TI A UK audit of screening for the metabolic side effects of antipsychotics
   in community patients
SO SCHIZOPHRENIA BULLETIN
LA English
DT Article
DE metabolic syndrome; obesity; diabetes; dyslipidemia; hypertension;
   psychosis
ID ATYPICAL ANTIPSYCHOTICS; DIABETES-MELLITUS; TREATED PATIENTS;
   WEIGHT-GAIN; SCHIZOPHRENIA; GLUCOSE; PREVALENCE; OBESITY; DISORDERS;
   CONSENSUS
AB Reviews of the association between psychotic disorder, the metabolic syndrome, diabetes, and antipsychotic drugs conclude that there is a need for active, routine physical health screening of patients' prescribed antipsychotic drugs. From published guidelines, we derived the audit standard that all such patients should, as a minimum, have their blood pressure, body mass index (BMI) (or other measure of obesity such as waist circumference), blood glucose (or HbA(1c)), and plasma lipids measured at least once a year. We conducted an audit of the clinical records of 1966 eligible patients under the care of 48 multidisciplinary, assertive outreach clinical teams in 21 mental health services across the United Kingdom. This revealed a recorded measurement within the previous year for blood pressure in 26% of the patients, obesity in 17%, blood glucose (or HbA(1c)) in 28% and plasma lipids in 22%, with all 4 measures documented in 11%. In the total national sample, 6% had a documented diagnosis of diabetes, 6% hypertension, and 6% dyslipidemia. Extrapolating from the prevalence of these disorders in similar populations suggests that for every patient with a known diagnosis of diabetes, another had not been recognized, for every known case of hypertension, 4 had been missed, and for every known case of dyslipidemia, 7 had been missed. The responses of the clinical teams to a questionnaire yielded information on obstacles to screening in routine practice, revealing uncertainty about whose responsibility this was, a lack of confidence about the interpretation of abnormal screening results, and limited access to basic equipment.
C1 Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Psychol Med, Div Neurosci & Mental Hlth, London W6 8RP, England.
   Royal Coll Psychiatrists, Ctr Qual Improvement, Prescribing Observ Mental Hlth, London E1 8AA, England.
   Maudsley Hosp & Inst Psychiat, S London & Maudsley NHS Trust, London SE5 8AZ, England.
C3 Imperial College London; South London & Maudsley NHS Trust; Maudsley
   Hospital; University of London; King's College London
RP Barnes, TRE (corresponding author), Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Psychol Med, Div Neurosci & Mental Hlth, Charing Cross Campus,Reynolds Bldg,St Dunstans Rd, London W6 8RP, England.
EM t.r.barnes@imperial.ac.uk
RI Barnes, Thomas/KJC-1245-2024
OI Taylor, David/0000-0002-2557-1710
CR Allison DB, 1999, AM J PSYCHIAT, V156, P1686
   *AM DIAB ASS, 2004, DIABETES CARE S1, V27, P69
   Amer Diabet Assoc, 2004, DIABETES CARE, V27, P596, DOI 10.2337/diacare.27.2.596
   [Anonymous], CARDIOVASCULAR RISK
   [Anonymous], 2005, ADV PSYCHIAT TREAT, DOI [DOI 10.1192/apt.11.2.142, DOI 10.1192/APT.11.2.142]
   Antai-Otong D, 2004, PERSPECT PSYCHIATR C, V40, P70, DOI 10.1111/j.1744-6163.2004.00070.x
   Brown S, 1999, PSYCHOL MED, V29, P697, DOI 10.1017/S0033291798008186
   *CKS, 2007, SCHIZ PRODIGY GUID C
   Cohn TA, 2006, CAN J PSYCHIAT, V51, P492, DOI 10.1177/070674370605100804
   De Hert MA, 2006, SCHIZOPHR RES, V83, P87, DOI 10.1016/j.schres.2005.12.855
   De Hert M, 2006, EUR PSYCHIAT, V21, P224, DOI 10.1016/j.eurpsy.2005.05.011
   De Nayer A, 2005, INT J PSYCHIAT CLIN, V9, P130, DOI 10.1080/13651500510018310
   Dinan T, 2004, BRIT J PSYCHIAT, V184, pS112
   Filik R, 2006, ACTA PSYCHIAT SCAND, V113, P298, DOI 10.1111/j.1600-0447.2006.00768.x
   Goff DC, 2005, SCHIZOPHR RES, V80, P45, DOI 10.1016/j.schres.2005.08.010
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Haddad PM, 2004, BRIT J PSYCHIAT, V184, pS80, DOI 10.1192/bjp.184.47.s80
   Hennekens CH, 2005, AM HEART J, V150, P1115, DOI 10.1016/j.ahj.2005.02.007
   Hodgson R., 2006, PROG NEUROL PSYCHIAT, V10, P9
   Holt RIG, 2004, DIABETIC MED, V21, P515, DOI 10.1111/j.1464-5491.2004.01199.x
   Janssen I, 2004, AM J CLIN NUTR, V79, P379
   Kohen D, 2004, BRIT J PSYCHIAT, V184, pS64, DOI 10.1192/bjp.184.47.s64
   Lambert TJR, 2004, MED J AUSTRALIA, V181, P544, DOI 10.5694/j.1326-5377.2004.tb06443.x
   Lebovitz HE, 2003, PSYCHIAT QUART, V74, P277, DOI 10.1023/A:1024170622266
   Lemieux S, 1996, AM J CLIN NUTR, V64, P685, DOI 10.1093/ajcn/64.5.685
   Mackin P, 2005, DIABETOLOGIA, V48, P215, DOI 10.1007/s00125-004-1641-y
   MASTERSON E, 1984, BRIT J PSYCHIAT, V145, P429, DOI 10.1192/bjp.145.4.429
   McEvoy JP, 2005, SCHIZOPHR RES, V80, P19, DOI 10.1016/j.schres.2005.07.014
   Mir S, 2001, INT CLIN PSYCHOPHARM, V16, P63, DOI 10.1097/00004850-200103000-00001
   Motsinger Charles, 2006, Prim Care Companion J Clin Psychiatry, V8, P220
   National Institute for Clinical Excellence, 2002, SCHIZ COR INT TREATM
   NEWMAN SC, 1991, CAN J PSYCHIAT, V36, P239, DOI 10.1177/070674379103600401
   Paton C, 2004, ACTA PSYCHIAT SCAND, V110, P299, DOI 10.1111/j.1600-0447.2004.00372.x
   *ROY COLL PSYCH, 2006, 138 REV CONS STAT HI
   Saari K, 2004, J CLIN PSYCHIAT, V65, P547
   Schneider J, 2006, PSYCHIATR BULL, V30, P89, DOI 10.1192/pb.30.3.89
   Sernyak MJ, 2003, J CLIN PSYCHIAT, V64, P605, DOI 10.4088/JCP.v64n0517
   Tarrant CJ, 2006, PSYCHIATR BULL, V30, P286, DOI 10.1192/pb.30.8.286
   Taylor D, 2005, J PSYCHOPHARMACOL, V19, P182, DOI 10.1177/0269881105049039
   Taylor D, 2004, BRIT J PSYCHIAT, V185, P152, DOI 10.1192/bjp.185.2.152
   Taylor DM, 2000, ACTA PSYCHIAT SCAND, V101, P416, DOI 10.1034/j.1600-0447.2000.101006416.x
NR 41
TC 120
Z9 124
U1 0
U2 21
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0586-7614
EI 1745-1701
J9 SCHIZOPHRENIA BULL
JI Schizophr. Bull.
PD NOV
PY 2007
VL 33
IS 6
BP 1397
EP 1403
DI 10.1093/schbul/sbm038
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 227VR
UT WOS:000250686400020
PM 17483101
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Fujii, M
   Kakimoto, M
   Sato, I
   Honma, K
   Kirihara, S
   Nakayama, H
   Fukuoka, T
   Hirohata, S
   Kitamori, K
   Ran, S
   Yamamoto, S
   Watanabe, S
AF Fujii, Moe
   Kakimoto, Mai
   Sato, Ikumi
   Honma, Koki
   Kirihara, Sora
   Nakayama, Hinako
   Fukuoka, Taketo
   Hirohata, Satoshi
   Kitamori, Kazuya
   Ran, Shang
   Yamamoto, Shusei
   Watanabe, Shogo
TI Uric Acid Elevation by Fructose Overload Exacerbates Nash and
   Atherosclerosis via Oxidative Stress
SO CURRENT NUTRITION & FOOD SCIENCE
LA English
DT Article
DE Atherosclerosis; fructose; nonalcoholic steatohepatitis (NASH);
   oxidative stress; stroke-prone spontaneously hypertensive rat 5
   (SHRSP5); uric acid
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; NONALCOHOLIC STEATOHEPATITIS;
   FIBROTIC STEATOHEPATITIS; DIETARY FRUCTOSE; NITRIC-OXIDE; HYPERURICEMIA;
   SHRSP5/DMCR; SERUM; RAT
AB Background: Nonalcoholic steatohepatitis (NASH) is well associated with an increased risk of cardiovascular disease (CVD), regardless of risk factors for metabolic syndrome. However, intermediary factors between NASH and CVD remain unknown. In recent years, hyperuricemia has been associated not only with gout but also with several other organ diseases, such as hypertension, chronic renal failure, and metabolic syndrome. In addition, hyperuricemia was shown to frequently occur in patients with NASH and could be a risk factor for CVD. Furthermore, serum uric acid (UA) levels have been linked with fructose intake.Objectives: We hypothesized that fructose loading elevates UA levels and exacerbates NASH and atherosclerosis via oxidative stress.Methods: Stroke-prone spontaneously hypertensive rats (SHRSP5/Dmcr), between 14 to 24 weeks of age, were divided into two groups and fed a high-fat and high-cholesterol (HFC) diet. In addition to the HFC diet, the fructose group was subjected to 10% fructose loading. The oral glucose tolerance test (OGTT) and insulin tolerance test (ITT) were performed at 25-week-old, followed by blood sampling, animal sacrifice, endothelial function test, blood biochemistry, histopathological staining, xanthine oxidase activity test, and genetic analysis performed at 26-week-old.Results: Fructose loading increased UA and oxidative stress levels. In addition, fructose loading induced insulin resistance. The fructose group exhibited aggravated hepatic fibrosis and lipid deposition, as well as enhanced lipid accumulation in the mesenteric arteries.Conclusion: In the SHRSP5/Dmcr rat model, elevated UA levels were a risk factor for the exacerbation of NASH and atherosclerosis via oxidative stress.
C1 [Fujii, Moe; Kakimoto, Mai; Sato, Ikumi; Honma, Koki; Kirihara, Sora; Nakayama, Hinako; Yamamoto, Shusei] Okayama Univ, Dept Med Technol, Grad Sch Hlth Sci, Kita Ku, 2-5-1 Shikata Cho,Kita Ku, Okayama, Okayama 7008558, Japan.
   [Fukuoka, Taketo] Okayama Univ, Fac Hlth Sci, Dept Med Technol, 2-5-1 Shikata Cho,Kita Ku, Okayama, Okayama 7008558, Japan.
   [Hirohata, Satoshi; Yamamoto, Shusei; Watanabe, Shogo] Okayama Univ, Acad Field Hlth Sci, 2-5-1 Shikata Cho,Kita Ku, Okayama, Okayama 7008558, Japan.
   [Kitamori, Kazuya] Kinjo Gakuin Univ, Collage Human Life & Environm, 2-1723 Omori,Moriyama Ku, Nagoya, Aichi 4638521, Japan.
   [Ran, Shang] HeiLongjiang Prov Ctr Dis Control & Prevent, Harbin 150030, Peoples R China.
C3 Okayama University; Okayama University; Okayama University
RP Watanabe, S (corresponding author), Okayama Univ, Acad Field Hlth Sci, 2-5-1 Shikata Cho,Kita Ku, Okayama, Okayama 7008558, Japan.
EM watanabe1224@okayama-u.ac.jp
RI Hirohata, Satoshi/M-5250-2019
OI Yamamoto, Shusei/0009-0004-0582-2879
FU Japan Society for the Promotion [15K19178, 18K10993]; Gout Research
   Foundation of Japan [20H00548, 23K16796]; Grants-in-Aid for Scientific
   Research [20H00548] Funding Source: KAKEN
FX This work was supported by grants from the Japan Society for the
   Promotion of Grant Number 15K19178 and Grant-in-Aid for Scientific
   Research (C), Grant Number 18K10993, and Gout Research Foundation of
   Japan to S.Watanabe Grant Number 20H00548, 23K16796.
CR Abdelmalek MF, 2010, HEPATOLOGY, V51, P1961, DOI 10.1002/hep.23535
   Alderman M H, 2001, Curr Hypertens Rep, V3, P184, DOI 10.1007/s11906-001-0036-4
   Baskol G, 2007, CLIN BIOCHEM, V40, P776, DOI 10.1016/j.clinbiochem.2007.02.006
   BERGMAN RN, 1979, AM J PHYSIOL, V236, pE667, DOI 10.1152/ajpendo.1979.236.6.E667
   Bobridge KS, 2013, J HUM HYPERTENS, V27, P217, DOI 10.1038/jhh.2012.36
   Capeau J, 2008, DIABETES METAB, V34, P649, DOI 10.1016/S1262-3636(08)74600-7
   Chalasani N, 2012, GASTROENTEROLOGY, V142, P1592, DOI 10.1053/j.gastro.2012.04.001
   Collison KS, 2009, OBESITY, V17, P2003, DOI 10.1038/oby.2009.58
   Fisher CD, 2009, EUR J PHARMACOL, V613, P119, DOI 10.1016/j.ejphar.2009.04.002
   GALVIN P, 1992, DIABETIC MED, V9, P921, DOI 10.1111/j.1464-5491.1992.tb01732.x
   Gersch C, 2008, NUCLEOS NUCLEOT NUCL, V27, P967, DOI 10.1080/15257770802257952
   Grayson PC, 2011, ARTHRIT CARE RES, V63, P102, DOI 10.1002/acr.20344
   Hikita M, 2007, INTERNAL MED, V46, P1353, DOI 10.2169/internalmedicine.46.0045
   Horai Y, 2016, INT J EXP PATHOL, V97, P75, DOI 10.1111/iep.12169
   Hosoo S, 2015, MOLECULES, V20, P21971, DOI 10.3390/molecules201219826
   Iseki K, 2001, HYPERTENS RES, V24, P691, DOI 10.1291/hypres.24.691
   Jia XF, 2014, DIGEST DIS SCI, V59, P1490, DOI 10.1007/s10620-014-3028-3
   Jia XF, 2012, LIFE SCI, V90, P934, DOI 10.1016/j.lfs.2012.04.029
   Khosla UM, 2005, KIDNEY INT, V67, P1739, DOI 10.1111/j.1523-1755.2005.00273.x
   Kitamori Kazuya, 2012, Environmental Health and Preventive Medicine, V17, P173, DOI 10.1007/s12199-011-0235-9
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Konta T, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-63134-0
   Kozaki Y, 2015, J PHYSIOL SCI, V65, P417, DOI 10.1007/s12576-015-0380-9
   Kumar S., 2019, J. Dev. Drugs, V9, P1, DOI DOI 10.4172/2329-6631.1000195
   Kunitomo M, 2007, YAKUGAKU ZASSHI, V127, P1997, DOI 10.1248/yakushi.127.1997
   Matsuura N, 2015, AM J PHYSIOL-HEART C, V308, pH1275, DOI 10.1152/ajpheart.00906.2014
   Moriya Takashi, 2012, Environmental Health and Preventive Medicine, V17, P444, DOI 10.1007/s12199-012-0273-y
   Mosca A, 2017, J HEPATOL, V66, P1031, DOI 10.1016/j.jhep.2016.12.025
   Naito H, 2016, ENVIRON HEALTH PREV, V21, P368, DOI 10.1007/s12199-016-0539-x
   Nakatsu Y, 2015, AM J PHYSIOL-GASTR L, V309, pG42, DOI 10.1152/ajpgi.00443.2014
   Nd Asia Muhammad, 2019, Integr Med (Encinitas), V18, P42
   Nigro J, 2006, ENDOCR REV, V27, P242, DOI 10.1210/er.2005-0007
   Nosrati N, 2010, J ACUPUNCT MERIDIAN, V3, P104, DOI 10.1016/S2005-2901(10)60019-2
   Rolo AP, 2012, FREE RADICAL BIO MED, V52, P59, DOI 10.1016/j.freeradbiomed.2011.10.003
   Sánchez-Lozada LG, 2007, AM J PHYSIOL-RENAL, V292, pF1238, DOI 10.1152/ajprenal.00164.2006
   Sautin YY, 2007, AM J PHYSIOL-CELL PH, V293, pC584, DOI 10.1152/ajpcell.00600.2006
   Schwartz IF, 2011, J VASC RES, V48, P252, DOI 10.1159/000320356
   Sersté T, 2006, ACTA GASTRO-ENT BELG, V69, P296
   Sertoglu E, 2014, CLIN BIOCHEM, V47, P383, DOI 10.1016/j.clinbiochem.2014.01.029
   Sievenpiper JL, 2012, ANN INTERN MED, V156, P291, DOI 10.7326/0003-4819-156-4-201202210-00007
   Sparks JD, 2012, ARTERIOSCL THROM VAS, V32, P2104, DOI 10.1161/ATVBAHA.111.241463
   Sweet JG, 2015, J APPL PHYSIOL, V119, P817, DOI 10.1152/japplphysiol.00467.2015
   Targher G, 2010, NEW ENGL J MED, V363, P1341, DOI 10.1056/NEJMra0912063
   Toop CR, 2016, NUTRIENTS, V8, DOI 10.3390/nu8090577
   Vos MB, 2013, HEPATOLOGY, V57, P2525, DOI 10.1002/hep.26299
   Watanabe S, 2018, J ATHEROSCLER THROMB, V25, P439, DOI 10.5551/jat.40956
   Wei J, 2011, ENDOCRINOLOGY, V152, P3049, DOI 10.1210/en.2011-0045
   Williams CD, 2011, GASTROENTEROLOGY, V140, P124, DOI 10.1053/j.gastro.2010.09.038
   Yamamoto S, 2020, EXP MOL PATHOL, V114, DOI 10.1016/j.yexmp.2020.104437
   Yetti H, 2013, LIFE SCI, V93, P673, DOI 10.1016/j.lfs.2013.09.013
   Zharikov S, 2008, AM J PHYSIOL-CELL PH, V295, pC1183, DOI 10.1152/ajpcell.00075.2008
   Zhu P, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100801
NR 52
TC 1
Z9 1
U1 1
U2 1
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-4013
EI 2212-3881
J9 CURR NUTR FOOD SCI
JI Curr. Nutr. Food Sci.
PY 2024
VL 20
IS 2
BP 250
EP 261
DI 10.2174/1573401319666230508150159
PG 12
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA EL4H7
UT WOS:001139063400003
DA 2025-06-11
ER

PT J
AU Lilao-Garzón, J
   Brito-Casillas, Y
   Quesada-Canales, O
   Wägner, AM
   Muñoz-Descalzo, S
AF Lilao-Garzon, Joaquin
   Brito-Casillas, Yeray
   Quesada-Canales, Oscar
   Waegner, Ana M.
   Munoz-Descalzo, Silvia
TI Maternal age, obesity and hyperglycaemia are associated with a delay in
   preimplantation embryo development in mouse
SO REPRODUCTION
LA English
DT Article
ID DIABETES-MELLITUS; OXIDATIVE STRESS; GLUCOSE; METABOLISM; LESIONS;
   MODELS; HEALTH; TIME; ACID; RAT
AB Delayed maternal age, obesity and diabetes are associated with reduced fertility. We investigated how age and obesity/metabolic syndrome impact fertility and hypothesized that its decrease is due to defects in preimplantation embryo development. Three groups of female C57Bl6 mice (12 weeks, 9 months and 1 year old) were fed either a high-fat diet for 8 weeks, to induce obesity and the metabolic syndrome, or a control chow diet. Body weight and composition, glucose tolerance and insulin resistance were assessed. Fecundity was evaluated by mating and pregnancy rates, as well as by the number of embryos. Embryo quality was assessed morphologically, and cell fate composition was analysed in preimplantation embryos by state-of-the-art single-cell quantitative confocal image analysis. The high-fat diet was associated with increased adiposity, glucose intolerance and insulin resistance, especially in the older mice. Fecundity was affected by age more than by the diet. Both age and high-fat diet were associated with reduced cell fate allocation, indicating a delay in the preimplantation embryo development, and with increased expression of GATA3, an inhibitor of placentation. These results support that age and the metabolic syndrome reduce fertility through mechanisms which are present at conception or very early in pregnancy.
C1 [Lilao-Garzon, Joaquin; Brito-Casillas, Yeray; Waegner, Ana M.; Munoz-Descalzo, Silvia] ULPGC, IUIBS, Las Palmas Gran Canaria, Spain.
   [Quesada-Canales, Oscar] Univ Las Palmas Gran Canaria, Inst Anim Hlth, Sch Vet, Vet Histol & Pathol, Las Palmas Gran Canaria, Spain.
   [Waegner, Ana M.] Complejo Hosp Univ Insular Materno Infantil Gran, Serv Endocrinol & Nutr, Las Palmas Gran Canaria, Spain.
C3 Universidad de Las Palmas de Gran Canaria; Universidad de Las Palmas de
   Gran Canaria
RP Wägner, AM; Muñoz-Descalzo, S (corresponding author), ULPGC, IUIBS, Las Palmas Gran Canaria, Spain.; Wägner, AM (corresponding author), Complejo Hosp Univ Insular Materno Infantil Gran, Serv Endocrinol & Nutr, Las Palmas Gran Canaria, Spain.
RI Wägner, Ana/AAS-9601-2021; Quesada-Canales, Oscar/JZE-4935-2024;
   Munoz-Descalzo, Silvia/M-8094-2013; Brito Casillas, Yeray/U-6954-2018
OI Wagner, Ana M/0000-0002-7663-9308; Lilao-Garzon,
   Joaquin/0000-0002-9971-2459; Munoz-Descalzo, Silvia/0000-0003-0939-7721;
   Quesada-Canales, Oscar/0000-0002-2365-351X; Brito Casillas,
   Yeray/0000-0002-0707-7444
FU SMD lab by the ACIISI [CEI2019-02]; Programa de Ayudas a la
   Investigacion de la ULPGC; FEDER Funds [ProID2020010013]; Instituto de
   Salud Carlos III [PI16/00587, PI20/00846, PMP21/00069]; ACIISI
   [ProID2021010143]; European Regional Development Funds; European Horizon
   2020 Programme [101017385]; Fundacion Canaria del Instituto de
   Investigaciones Sanitarias de Canarias [PI19/30, PIFIISC20/16]; ULPGC
   pre-doctoral program
FX This work was supported at SMD lab by the ACIISI (CEI2019-02), Programa
   de Ayudas a la Investigacion de la ULPGC and ACIISI co-funded by FEDER
   Funds (ProID2020010013). Also at AMW lab by Instituto de Salud Carlos
   III (PI16/00587, PI20/00846, PMP21/00069) and ACIISI (ProID2021010143)
   co-funded by European Regional Development Funds, as well as the
   European Horizon 2020 Programme (101017385) and Fundacion Canaria del
   Instituto de Investigaciones Sanitarias de Canarias (PI19/30,
   PIFIISC20/16). JLG is supported by the ULPGC pre-doctoral program. SMD
   by the 'Viera y Clavijo' Program from the Agencia Canaria de
   Investigacion, Innovacion y Sociedad de la Informacion (ACIISI) and the
   ULPGC.
CR Andrikopoulos S, 2008, AM J PHYSIOL-ENDOC M, V295, pE1323, DOI 10.1152/ajpendo.90617.2008
   Bellver J, 2010, FERTIL STERIL, V93, P447, DOI 10.1016/j.fertnstert.2008.12.032
   Benedé-Ubieto R, 2020, DIABET METAB SYND OB, V13, P439, DOI 10.2147/DMSO.S234665
   Brinton RD, 2012, ENDOCRINOLOGY, V153, P3571, DOI 10.1210/en.2012-1340
   Brito-Casillas Y, 2016, ENDOCRINOL NUTR, V63, P345, DOI [10.1016/j.endonu.2016.03.011, 10.1016/j.endoen.2016.09.002]
   Chaix A, 2021, CELL REP, V36, DOI 10.1016/j.celrep.2021.109543
   Chan YK, 2012, LAB ANIM-UK, V46, P142, DOI 10.1258/la.2011.011136
   Chen T, 2020, BBA-MOL BASIS DIS, V1866, DOI 10.1016/j.bbadis.2020.165805
   Chiu YH, 2016, SCI REP-UK, V6, DOI 10.1038/srep21630
   Davalli P, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/3565127
   Dutta S, 2016, LIFE SCI, V152, P244, DOI 10.1016/j.lfs.2015.10.025
   Ezzati M, 2017, LANCET, V390, P2627, DOI [10.1016/S0140-6736(17)32129-3, 10.1016/s0140-6736(17)32129-3]
   Faruque S, 2019, POL J FOOD NUTR SCI, V69, P219, DOI 10.31883/pjfns/110735
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Fischer ASC., 2023, The Salt-and-Pepper Pattern in Mouse Blastocysts Is Compatible with Signalling beyond the Nearest Neighbours, DOI [10.2139/ssrn.4444691, DOI 10.2139/SSRN.4444691]
   Fischer SC, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0233030
   Fleming TP, 2018, LANCET, V391, P1842, DOI [10.1016/S0140-6736(18)30312-X, 10.1016/s0140-6736(18)30312-x]
   Gardner DK, 2016, MOL HUM REPROD, V22, P704, DOI 10.1093/molehr/gaw057
   Gargiulo S, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/253067
   Godfrey KM, 2017, LANCET DIABETES ENDO, V5, P53, DOI 10.1016/S2213-8587(16)30107-3
   Goldman RH, 2019, AM J OBSTET GYNECOL, V221, DOI 10.1016/j.ajog.2019.05.043
   Grzegorczyk-Martin V, 2020, HUM REPROD, V35, P2755, DOI 10.1093/humrep/deaa208
   HALL WC, 1992, TOXICOL PATHOL, V20, P146, DOI 10.1177/019262339202000202
   HORBER FF, 1990, ANESTHESIOLOGY, V73, P82, DOI 10.1097/00000542-199007000-00013
   Igosheva N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010074
   Jawerbaum A, 2010, ENDOCR REV, V31, P680, DOI 10.1210/er.2009-0038
   Larsen MD, 2020, DIABETOLOGIA, V63, P1736, DOI 10.1007/s00125-020-05193-6
   Lilao-Garzon J., 2021, Revista SECAL, V89, P21
   Lilao-Garzón J, 2021, ADV EXP MED BIOL, V1307, P553, DOI 10.1007/5584_2020_536
   Lou XH, 2014, STEM CELL REP, V2, P382, DOI 10.1016/j.stemcr.2014.01.010
   Mattsson K, 2021, FERTIL STERIL, V116, P505, DOI 10.1016/j.fertnstert.2021.02.009
   Miao XS, 2022, BIOL REPROD, V106, P699, DOI 10.1093/biolre/ioac002
   Myrskylä M, 2012, DEMOGRAPHY, V49, P1231, DOI 10.1007/s13524-012-0132-x
   Nandi A, 2013, ENDOCRIN METAB CLIN, V42, P915, DOI 10.1016/j.ecl.2013.07.007
   Nichols J, 2009, DEVELOPMENT, V136, P3215, DOI 10.1242/dev.038893
   Ornoy A, 2015, BIRTH DEFECTS RES C, V105, P53, DOI 10.1002/bdrc.21090
   Ozekinci M, 2015, BMC WOMENS HEALTH, V15, DOI 10.1186/s12905-015-0223-0
   du Sert NP, 2020, BMC VET RES, V16, DOI 10.1186/s12917-020-02451-y
   Percy DH., 2016, PATHOLOGY LAB RODENT
   Picklo MJ Sr, 2017, PROSTAG LEUKOTR ESS, V119, P25, DOI 10.1016/j.plefa.2017.03.001
   Qi L, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.856667
   Rehman K, 2017, J CELL BIOCHEM, V118, P3577, DOI 10.1002/jcb.26097
   Rossant J, 2018, ANNU REV GENET, V52, P185, DOI 10.1146/annurev-genet-120116-024544
   Saiz N, 2020, ELIFE, V9, DOI 10.7554/eLife.56079
   Saiz N, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms13463
   Shenk M., 2015, The International Encyclopedia of Human Sexuality, P369, DOI [10.1002/9781118896877.wbiehs153, DOI 10.1002/9781118896877.WBIEHS153]
   Silvestris E, 2018, REPROD BIOL ENDOCRIN, V16, DOI 10.1186/s12958-018-0336-z
   Sneed ML, 2008, HUM REPROD, V23, P1835, DOI 10.1093/humrep/den188
   Soleimanzad H, 2021, OBESITY, V29, P150, DOI 10.1002/oby.23051
   Tessitore A, 2016, BMC CANCER, V16, DOI 10.1186/s12885-015-2007-1
   Thong EP, 2020, LANCET DIABETES ENDO, V8, P134, DOI 10.1016/S2213-8587(19)30345-6
   Thoolen B, 2010, TOXICOL PATHOL, V38, p5S, DOI 10.1177/0192623310386499
   Willard-Mack CL, 2019, TOXICOL PATHOL, V47, P665, DOI 10.1177/0192623319867053
   Yu Q, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0231090
NR 54
TC 3
Z9 3
U1 1
U2 4
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 1470-1626
EI 1741-7899
J9 REPRODUCTION
JI Reproduction
PD SEP 1
PY 2023
VL 166
IS 3
BP 235
EP 245
DI 10.1530/REP-23-0024
PG 11
WC Developmental Biology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology; Reproductive Biology
GA ML6B8
UT WOS:001193805100001
PM 37889771
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Santana, AIC
   das Merces, MC
   de Souza, MC
   Lima, BGD
   Galdino, MJQ
   Félix, NDD
   Magalhaes, LBNC
   Coelho, JMF
   Barbosa, PJB
   Gomes, EVD
   Pimentel, RFW
   de Sousa, AR
   de Oliveira, MAF
   de Queiroz, AM
   Florencio, RMS
   Neto, JLC
   Gomes, AMT
   Santos, TBS
   Vieira, SL
   de Sousa, DG
   de Andrade, PCDT
   Maduro, IPDN
   Fernandes, SL
   Damasceno, KSM
   da Silva, DAR
   D'Oliveira, A Jr
AF Costa Santana, Amalia Ivine
   das Merces, Magno Conceicao
   de Souza, Marcio Costa
   de Carvalho Lima, Bruno Gil
   Quina Galdino, Maria Jose
   de Carvalho Felix, Nuno Damacio
   Neves Cunha Magalhaes, Lucelia Batista
   Freitas Coelho, Julita Maria
   Bastos Barbosa, Paulo Jose
   Dias Gomes, Erica Velasco
   Weyll Pimentel, Rodrigo Fernandes
   de Sousa, Anderson Reis
   Ferreira de Oliveira, Marcia Aparecida
   de Queiroz, Aline Macedo
   Silva Florencio, Raissa Millena
   Cavalcante Neto, Jorge Lopes
   Tosoli Gomes, Antonio Marcos
   Souza Santos, Thadeu Borges
   Vieira, Silvana Lima
   de Sousa, Danilo Guimaraes
   da Silva Thiengo de Andrade, Priscila Cristina
   de Negreiros Nogueira Maduro, Isolda Prado
   Fernandes, Sandra Lucia
   Meneses Damasceno, Kairo Silvestre
   Reis da Silva, Dandara Almeida
   D'Oliveira Junior, Argemiro
TI Interaction between Work and Metabolic Syndrome: A Population-Based
   Cross-Sectional Study
SO HEALTHCARE
LA English
DT Article
DE epidemiological studies; metabolic syndrome; professional burnout;
   worker's health; primary health care
ID LIFE-STYLE; PREVALENCE; BURNOUT; STRESS
AB Metabolic syndrome (MS) is a clinical condition and a relevant risk factor in the development of cardiovascular diseases; it occurs as a result of lifestyle factors, e.g., work. The aim of this research was to estimate the interaction between work and MS among primary health care (PHC) nursing professionals in the state of Bahia, Brazil. A sectional multicentered study carried out in 43 municipalities in Bahia, whose study population consisted of nursing professionals. The exposure variables were occupation, professional exhaustion, and working time, and the outcome variable was MS. Interaction measures based on the additivity criteria were verified by calculating the excess risks due to the interactions and according to the proportion of cases attributed to the interactions and the synergy index. The global MS prevalence is 24.4%. There was a greater magnitude in the exposure group regarding the three investigated factors (average level occupation, professional exhaustion, and working time in PHC for more than 5 years), reaching an occurrence of 44.9% when compared to the prevalence of 13.1% in the non-exposure group (academic education, without professional burnout, and working time in PHC for up to 5 years). The study's findings showed a synergistic interaction of work aspects for MS occurrence among PHC nursing professionals.
C1 [Costa Santana, Amalia Ivine; das Merces, Magno Conceicao; Weyll Pimentel, Rodrigo Fernandes; Meneses Damasceno, Kairo Silvestre; D'Oliveira Junior, Argemiro] Fed Univ Bahia UFBA, Sch Med, Hlth Sci Postgrad Program, BR-40026010 Salvador, BA, Brazil.
   [das Merces, Magno Conceicao; de Souza, Marcio Costa; Freitas Coelho, Julita Maria; Bastos Barbosa, Paulo Jose; Dias Gomes, Erica Velasco; Weyll Pimentel, Rodrigo Fernandes; Cavalcante Neto, Jorge Lopes; Souza Santos, Thadeu Borges; Vieira, Silvana Lima; de Sousa, Danilo Guimaraes; Meneses Damasceno, Kairo Silvestre; Reis da Silva, Dandara Almeida] State Univ Bahia UNEB, Dept Life Sci, BR-41150000 Salvador, BA, Brazil.
   [das Merces, Magno Conceicao; de Carvalho Lima, Bruno Gil; Neves Cunha Magalhaes, Lucelia Batista] Fed Univ Bahia UFBA, FTC Univ Ctr UniFTC, BR-41741590 Salvador, BA, Brazil.
   [de Carvalho Lima, Bruno Gil] Fed Univ Bahia UFBA, Sch Med, Dept Pathol & Forens Med, BR-40026010 Salvador, BA, Brazil.
   [Quina Galdino, Maria Jose] State Univ Northern Parana UENP, Dept Nursing, BR-86360000 Bandeirantes, Parana, Brazil.
   [de Carvalho Felix, Nuno Damacio] Fed Univ Reconcavo Bahia UFRB, Hlth Sci Ctr, BR-44574490 Santo Antonio De Jesus, BA, Brazil.
   [Neves Cunha Magalhaes, Lucelia Batista] Fed Univ Bahia UFBA, Sch Med, Dept Family Hlth, BR-40026010 Salvador, BA, Brazil.
   [Weyll Pimentel, Rodrigo Fernandes; de Negreiros Nogueira Maduro, Isolda Prado; Fernandes, Sandra Lucia] Brazilian Assoc Nutr ABRAN, BR-15801150 Catanduva, SP, Brazil.
   [de Sousa, Anderson Reis] Fed Univ Bahia UFBA, Sch Nursing, BR-40231300 Salvador, BA, Brazil.
   [Ferreira de Oliveira, Marcia Aparecida] Univ Sao Paulo, Sch Nursing, Dept Maternal Child & Psychiat Nursing, BR-05403000 Sao Paulo, SP, Brazil.
   [de Queiroz, Aline Macedo; Silva Florencio, Raissa Millena] Fed Univ UFPA, Sch Nursing, BR-66075110 Belem, Para, Brazil.
   [Tosoli Gomes, Antonio Marcos; da Silva Thiengo de Andrade, Priscila Cristina] State Univ Rio de Janeiro UERJ, Sch Nursing, BR-20551030 Rio De Janeiro, Brazil.
   [de Negreiros Nogueira Maduro, Isolda Prado] State Univ Amazonas UEA, Dept Clin Nutr, BR-69850000 Manaus, Amazonas, Brazil.
C3 Universidade do Estado Bahia; Universidade Estadual do Norte do Parana
   (UENP); Universidade de Sao Paulo; Universidade Federal do Para;
   Universidade do Estado do Rio de Janeiro; Universidade do Estado do
   Amazonas
RP das Merces, MC (corresponding author), Fed Univ Bahia UFBA, Sch Med, Hlth Sci Postgrad Program, BR-40026010 Salvador, BA, Brazil.; das Merces, MC (corresponding author), State Univ Bahia UNEB, Dept Life Sci, BR-41150000 Salvador, BA, Brazil.; das Merces, MC (corresponding author), Fed Univ Bahia UFBA, FTC Univ Ctr UniFTC, BR-41741590 Salvador, BA, Brazil.
EM amalia0807@gmail.com; mmerces@uneb.br; mcsouza@uneb.br;
   brunogil@doctor.com; mariagaldino@uenp.edu.br; nunofelix@ufrb.edu.br;
   luceliamagalhaes@terra.com.br; julitamaria@gmail.com; pjbarbosa@uneb.br;
   enfa.ericavelasco@gmail.com; rodrigo.pimentel@ebserh.gov.br;
   anderson.sousa@ufba.br; marciaap@usp.br; alinemacedo@ufpa.br;
   raissaflorencio@yahoo.com.br; jlcavalcante@uneb.br; mtosoli@gmail.com;
   tbssantos@uneb.br; slvieira@uneb.br; danilogs26@gmail.com;
   profprithiengo@gmail.com; isoldaprado@yahoo.com.br;
   sandranut@yahoo.com.br; kairodamasceno@hotmail.com; darsilva@uneb.br;
   argemiro@ufba.br
RI Cavalcante Neto, Jorge/R-9699-2016; MAGALHÃES, LUCELIA/AAA-1378-2019;
   gomes, erica/IAM-1895-2023; Gomes, A./Q-6844-2016; Vieira,
   Silvana/IZP-6746-2023; Carvalho Félix, Nuno Damácio de/V-6536-2019;
   Merces, Magno/S-6649-2017; GALDINO, MARIA/K-4754-2019; de Sousa,
   Anderson/AAU-7163-2021; Silva Thiengo de Andrade, Priscila
   Cristina/AAE-8949-2022; Florencio, Raissa/KIA-3373-2024; Costa de Souza,
   Marcio/Y-8859-2018; Ferreira de Oliveira, Marcia Aparecida/E-6272-2012
OI Silva Thiengo de Andrade, Priscila Cristina/0000-0003-0840-4838; VELASCO
   DIAS GOMES, ERICA/0000-0003-0643-4355; Florencio,
   Raissa/0000-0002-5085-830X; Galdino, Maria Jose
   Quina/0000-0001-6709-3502; Pimentel, Rodrigo Fernandes
   Weyll/0000-0003-0101-0190; REIS DE SOUSA, ANDERSON/0000-0001-8534-1960;
   Lima, Bruno/0000-0002-1200-4629; Silvestre Meneses Damasceno,
   Kairo/0000-0002-2444-4496; de Carvalho Felix, Nuno
   Damacio/0000-0002-0102-3023; Costa de Souza, Marcio/0000-0002-4922-6786;
   Ferreira de Oliveira, Marcia Aparecida/0000-0002-1069-8700; Coelho,
   Julita/0000-0002-9520-5177; Merces, Magno Conceicao
   das/0000-0003-3493-8606
FU National Council for Scientific and Technological Development (CNPq),
   Brazil [408390/2016-6]
FX Financial support from the National Council for Scientific and
   Technological Development (CNPq), Brazil, Universal Call Notice-protocol
   #408390/2016-6.
CR [Anonymous], 2007, Anthropometry Procedures Manual
   [Anonymous], 2011, EPIDEMIOLOGIA MODERN
   Oliveira LVA, 2020, CIENC SAUDE COLETIVA, V25, P4269, DOI 10.1590/1413-812320202511.31202020
   Aune D, 2017, EUR J EPIDEMIOL, V32, P181, DOI 10.1007/s10654-017-0232-4
   Borel AL, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112628
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Chico-Barba G, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16111993
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   das Merces MC, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17020474
   das Merces MC, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16152686
   Doughty KN, 2017, CURR CARDIOL REP, V19, DOI 10.1007/s11886-017-0925-z
   González-Vereau Alicia, 2017, Horiz. Med., V17, P18, DOI 10.24265/horizmed.2017.v17n3.04
   Grant N, 2009, INT J BEHAV MED, V16, P259, DOI 10.1007/s12529-009-9032-x
   Hartley Tara A, 2011, Int J Emerg Ment Health, V13, P243
   Itani O, 2017, SLEEP MED, V39, P87, DOI 10.1016/j.sleep.2017.07.027
   Jackson ER, 2016, ACAD MED, V91, P1251, DOI 10.1097/ACM.0000000000001138
   Jonsdottir IH, 2019, EUR J ENDOCRINOL, V180, pR147, DOI 10.1530/EJE-18-0741
   Kolb H, 2010, DIABETOLOGIA, V53, P10, DOI 10.1007/s00125-009-1573-7
   Machado MH, 2017, Perfil da Enfermagem no Brasil-Relatorio Final
   Maciel Regina Heloisa Mattei de Oliveira, 2015, Rev. bras. saúde ocup., V40, P75
   [Anonymous], 2010, Arq. Bras. Cardiol., V95, pI, DOI [10.5935/abc.20160153, 10.5935/abc.20160152]
   Malta DC, 2020, ARQ BRAS CARDIOL, V115, P152, DOI 10.36660/abc.20190867
   das Merces MC, 2021, ARCH ENVIRON OCCUP H, V76, P266, DOI 10.1080/19338244.2020.1819186
   Ministerio da Saude Brasil, 2012, POLITICA NACL ATENCO
   Nakata Akinori, 2012, Methods Mol Biol, V934, P39, DOI 10.1007/978-1-62703-071-7_3
   Nam JY, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-3617-5
   Oh JI, 2018, IND HEALTH, V56, P40, DOI 10.2486/indhealth.2017-0072
   Palomino Baldeon J.C., 2010, MED SEGUR TRAB, V56, P280, DOI [10.4321/S0465-546X2010000400004, DOI 10.4321/S0465-546X2010000400004]
   Pietroiusti A, 2010, OCCUP ENVIRON MED, V67, P54, DOI 10.1136/oem.2009.046797
   Ptácek R, 2019, MED SCI MONITOR, V25, P4974, DOI 10.12659/MSM.914205
   Puttonen S, 2012, SCAND J WORK ENV HEA, V38, P343, DOI 10.5271/sjweh.3267
   Ramirez AJ, 1996, LANCET, V347, P724, DOI 10.1016/S0140-6736(96)90077-X
   Ribeiro RP, 2015, REV LAT-AM ENFERM, V23, P435
   Tamayo Mauricio Robayo, 2002, Estud. psicol. (Natal), V7, P37
   Felipe-de-Melo ERT, 2011, CIENC SAUDE COLETIVA, V16, P3443, DOI 10.1590/S1413-81232011000900012
   Tsou MT, 2021, J OCCUP HEALTH, V63, DOI 10.1002/1348-9585.12188
   Vinnikov D, 2019, ARCH PUBLIC HEALTH, V77, DOI 10.1186/s13690-019-0345-1
   Yamaguchi M, 2018, J OCCUP HEALTH, V60, P485, DOI 10.1539/joh.2017-0298-OA
   Zhang JY, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000017306
NR 39
TC 1
Z9 1
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD MAR
PY 2022
VL 10
IS 3
AR 544
DI 10.3390/healthcare10030544
PG 12
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA 0C3TL
UT WOS:000775239600001
PM 35327022
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sun, DQ
   Wu, SJ
   Liu, WY
   Lu, QD
   Zhu, GQ
   Shi, KQ
   Braddock, M
   Song, D
   Zheng, MH
AF Sun, Dan-Qin
   Wu, Sheng-Jie
   Liu, Wen-Yue
   Lu, Qian-Di
   Zhu, Gui-Qi
   Shi, Ke-Qing
   Braddock, Martin
   Song, Dan
   Zheng, Ming-Hua
TI Serum uric acid: a new therapeutic target for nonalcoholic fatty liver
   disease
SO EXPERT OPINION ON THERAPEUTIC TARGETS
LA English
DT Review
DE metabolic syndrome; insulin resistance; inflammasomes; therapeutic
   options; nonalcoholic fatty liver disease; serum uric acid
ID METABOLIC SYNDROME; NLRP3 INFLAMMASOME; INSULIN-RESISTANCE;
   CARDIOVASCULAR RISK; LIPID-ACCUMULATION; OXIDATIVE STRESS; CHINESE
   ADULTS; GLUCOSE-UPTAKE; HYPERURICEMIA; ASSOCIATION
AB Introduction: Nonalcoholic fatty liver disease (NAFLD) is a major, worldwide public health problem. NAFLD is recognized as a major cause of liver-related morbidity and mortality. However, physicians are currently limited by available treatment options. Recently, numerous studies have reported a correlation between serum uric acid (SUA) and NAFLD with numerous clinical and experimental studies demonstrating a significant correlation. This review will focus on the role of SUA in the development of NAFLD and its potential role as a new target for therapeutic intervention.Areas covered: This review discusses SUA as a significant independent factor in the development of NAFLD. Moreover, we introduce the causal relationship between SUA, metabolic syndrome, and NAFLD. We discuss two major theories of insulin resistance and inflammasomes as potential explanations of the mechanistic link between SUA and NAFLD. In addition, we review current and emerging therapeutic medications to control appropriate SUA levels.Expert opinion: There is an urgent need to develop novel, safe and effective therapies for the growing NAFLD epidemic. Reduction of SUA may be a promising potential treatment for patients with NAFLD. Clinical studies are required to determine the therapeutic effect of attenuation of hyperuricemia in humans with NAFLD.
C1 [Sun, Dan-Qin; Lu, Qian-Di; Song, Dan] Nanjing Med Univ, Affiliated Wuxi Hosp 2, Dept Nephrol, Wuxi 214002, Peoples R China.
   [Wu, Sheng-Jie] Wenzhou Med Univ, Dept Cardiovasc Med, Ctr Heart, Affiliated Hosp 1, Wenzhou 325000, Peoples R China.
   [Liu, Wen-Yue] Wenzhou Med Univ, Dept Endocrinol, Affiliated Hosp 1, Wenzhou 325000, Peoples R China.
   [Zhu, Gui-Qi; Shi, Ke-Qing; Zheng, Ming-Hua] Wenzhou Med Univ, Dept Infect & Liver Dis, Affiliated Hosp 1, Liver Res Ctr, Wenzhou 325000, Peoples R China.
   [Zhu, Gui-Qi] Wenzhou Med Univ, Sch Clin Med Sci 1, Wenzhou 325000, Peoples R China.
   [Shi, Ke-Qing; Zheng, Ming-Hua] Wenzhou Med Univ, Inst Hepatol, Wenzhou 325000, Peoples R China.
   [Braddock, Martin] AstraZeneca R&D, Global Medicines Dev, Alderley Pk, England.
C3 Nanjing Medical University; Wenzhou Medical University; Wenzhou Medical
   University; Wenzhou Medical University; Wenzhou Medical University;
   Wenzhou Medical University; AstraZeneca
RP Song, D (corresponding author), Nanjing Med Univ, Affiliated Wuxi Hosp 2, Dept Nephrol, Wuxi 214002, Peoples R China.; Zheng, MH (corresponding author), Wenzhou Med Univ, Dept Infect & Liver Dis, Affiliated Hosp 1, Liver Res Ctr, Wenzhou 325000, Peoples R China.; Zheng, MH (corresponding author), Wenzhou Med Univ, Inst Hepatol, Wenzhou 325000, Peoples R China.
EM sdwx66@163.com; zhengmh@wmu.edu.cn
RI Liu, Wenyue/KDM-8848-2024; Zheng, Ming-Hua/H-5584-2019; Shi,
   KeQing/A-3411-2009; Zhu, Gui-Qi/H-9265-2017
OI Zheng, Ming-Hua/0000-0003-4984-2631; Liu, Wen-yue/0000-0003-1454-7077;
   Shi, KeQing/0000-0002-5070-3834; Zhu, Gui-Qi/0000-0001-5089-6923; Sun,
   Dan-Qin/0000-0002-8704-3606
FU National Natural Science Foundation of China [81500665]; Scientific and
   Technological Development Fundation of Nanjing Medical University Grants
   [2013NJMU190]; Scientific Research Foundation of Wenzhou, Zhejiang
   Province, China [H20090014, Y20090269]; Health Bureau of Zhejiang
   Province [2010KYB070]; Research Foundation of Education Bureau of
   Zhejiang Province [Y201009942]; Research Funds for Tian Qing Liver
   Diseases [TQGB20120057]; Project of New Century 551 Talent Nurturing in
   Wenzhou
FX This work was supported by grants from National Natural Science
   Foundation of China (81500665), Scientific and Technological Development
   Fundation of Nanjing Medical University Grants (2013NJMU190), the
   Scientific Research Foundation of Wenzhou, Zhejiang Province, China
   (H20090014, Y20090269), Health Bureau of Zhejiang Province (2010KYB070),
   Research Foundation of Education Bureau of Zhejiang Province
   (Y201009942), Research Funds for Tian Qing Liver Diseases (TQGB20120057)
   and Project of New Century 551 Talent Nurturing in Wenzhou. The authors
   have no other relevant affiliations or financial involvement with any
   organization or entity with a financial interest in or financial
   conflict with the subject matter or materials discussed in the
   manuscript apart from those disclosed.
CR Abeles AM, 2012, J RHEUMATOL, V39, P659, DOI 10.3899/jrheum.111161
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Amarapurkar DN, 2007, J GASTROEN HEPATOL, V22, P788, DOI 10.1111/j.1440-1746.2007.05042.x
   Angulo P, 2002, NEW ENGL J MED, V346, P1221, DOI 10.1038/nrdp.2015.80
   [Anonymous], 2015, Molecular and cellular endocrinology
   Baba T, 2007, HYPERTENS RES, V30, P823, DOI 10.1291/hypres.30.823
   Baldwin W, 2011, DIABETES, V60, P1258, DOI 10.2337/db10-0916
   BASTOW MD, 1988, METABOLISM, V37, P217, DOI 10.1016/0026-0495(88)90098-4
   Bergamini C, 2009, EUR J HEART FAIL, V11, P444, DOI 10.1093/eurjhf/hfp042
   Bugianesi E, 2005, HEPATOLOGY, V42, P987, DOI 10.1002/hep.20920
   Cardoso AS, 2013, J PEDIAT-BRAZIL, V89, P412, DOI 10.1016/j.jped.2012.12.008
   Choi HK, 2007, AM J MED, V120, P442, DOI 10.1016/j.amjmed.2006.06.040
   Choi YJ, 2014, LAB INVEST, V94, P1114, DOI 10.1038/labinvest.2014.98
   Conen D, 2004, BMC PUBLIC HEALTH, V4, DOI 10.1186/1471-2458-4-9
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   de Alwis NMW, 2008, J HEPATOL, V48, pS104, DOI 10.1016/j.jhep.2008.01.009
   Diaz-Torné C, 2015, CURR OPIN RHEUMATOL, V27, P164, DOI 10.1097/BOR.0000000000000146
   Duseja A, 2015, J CLIN EXP HEPATOL, V5, P51, DOI 10.1016/j.jceh.2015.02.006
   Edwards NL, 2014, RHEUM DIS CLIN N AM, V40, P375, DOI 10.1016/j.rdc.2014.01.013
   Eguchi Y, 2006, J GASTROENTEROL, V41, P462, DOI 10.1007/s00535-006-1790-5
   FACCHINI F, 1991, JAMA-J AM MED ASSOC, V266, P3008, DOI 10.1001/jama.266.21.3008
   Filippatos TD, 2010, WORLD J HEPATOL, V2, P139, DOI 10.4254/wjh.v2.i4.139
   Frampton JE, 2015, DRUGS, V75, P427, DOI 10.1007/s40265-015-0360-7
   GALVAN AQ, 1995, AM J PHYSIOL-ENDOC M, V268, pE1, DOI 10.1152/ajpendo.1995.268.1.E1
   García-Ruiz I, 2006, HEPATOLOGY, V44, P581, DOI 10.1002/hep.21313
   Gregoire FM, 2009, MOL ENDOCRINOL, V23, P975, DOI 10.1210/me.2008-0473
   Hanley AJG, 2004, DIABETES, V53, P1773, DOI 10.2337/diabetes.53.7.1773
   Haring R, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039461
   Huang HY, 2005, ARTHRITIS RHEUM, V52, P1843, DOI 10.1002/art.21105
   Ilkun O, 2013, CURR PHARM DESIGN, V19, P4806, DOI 10.2174/1381612811319270003
   Ives A, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms7555
   Khanna PP, 2015, CURR OPIN RHEUMATOL, V27, P139, DOI 10.1097/BOR.0000000000000154
   Kim HK, 2009, AM J MED SCI, V337, P98, DOI 10.1097/MAJ.0b013e3181812879
   Lanaspa MA, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0047948, 10.1371/journal.pone.0048801]
   Lee JW, 2010, GUT LIVER, V4, P378, DOI 10.5009/gnl.2010.4.3.378
   Lee Ju-Mi, 2012, J Prev Med Public Health, V45, P181, DOI 10.3961/jpmph.2012.45.3.181
   Lee MHH, 2008, DRUG SAFETY, V31, P643, DOI 10.2165/00002018-200831080-00002
   Lee YJ, 2010, CLIN CHEM LAB MED, V48, P175, DOI 10.1515/CCLM.2010.037
   Li CG, 2013, CURR OPIN RHEUMATOL, V25, P210, DOI 10.1097/BOR.0b013e32835d951e
   Li YM, 2009, J HEPATOL, V50, P1029, DOI 10.1016/j.jhep.2008.11.021
   Liang J, 2015, EUR REV MED PHARMACO, V19, P305
   Lin HZ, 2000, NAT MED, V6, P998, DOI 10.1038/79697
   Lin Shi-Dou, 2006, J Chin Med Assoc, V69, P512
   Liu PJ, 2014, CLIMACTERIC, V17, P692, DOI 10.3109/13697137.2014.926323
   Lonardo A, 2002, DIGEST LIVER DIS, V34, P204, DOI 10.1016/S1590-8658(02)80194-3
   Malnick SDH, 2003, QJM-INT J MED, V96, P699, DOI 10.1093/qjmed/hcg120
   Mangge H, 2013, OBESITY, V21, pE71, DOI 10.1002/oby.20061
   Marchesini G, 2003, HEPATOLOGY, V37, P917, DOI 10.1053/jhep.2003.50161
   Matafome P, 2011, DIABETES-METAB RES, V27, P54, DOI 10.1002/dmrr.1157
   Mummadi RR, 2008, CLIN GASTROENTEROL H, V6, P1396, DOI 10.1016/j.cgh.2008.08.012
   Muscelli E, 1996, AM J HYPERTENS, V9, P746, DOI 10.1016/0895-7061(96)00098-2
   Nakagawa T, 2005, NAT CLIN PRACT NEPHR, V1, P80, DOI 10.1038/ncpneph0019
   Nakahara T, 2014, J GASTROENTEROL, V49, P1477, DOI 10.1007/s00535-013-0911-1
   Nakatsu Y, 2015, AM J PHYSIOL-GASTR L, V309, pG42, DOI 10.1152/ajpgi.00443.2014
   Onat A, 2011, EXPERT OPIN PHARMACO, V12, P1887, DOI 10.1517/14656566.2011.585462
   Rees F, 2014, NAT REV RHEUMATOL, V10, P271, DOI 10.1038/nrrheum.2014.32
   Reinders MK, 2009, ANN RHEUM DIS, V68, P892, DOI 10.1136/ard.2008.091462
   Reinders MK, 2009, ANN RHEUM DIS, V68, P51, DOI 10.1136/ard.2007.083071
   Roy D, 1998, AM J PHYSIOL-ENDOC M, V274, pE692, DOI 10.1152/ajpendo.1998.274.4.E692
   Ruggiero C, 2006, EUR HEART J, V27, P1174, DOI 10.1093/eurheatj/ehi879
   Ruggiero C, 2007, AM J CARDIOL, V100, P115, DOI 10.1016/j.amjcard.2007.02.065
   Schroder K, 2010, SCIENCE, V327, P296, DOI 10.1126/science.1184003
   Sertoglu E, 2014, CLIN BIOCHEM, V47, P383, DOI 10.1016/j.clinbiochem.2014.01.029
   Shih MH, 2015, J FORMOS MED ASSOC, V114, P314, DOI 10.1016/j.jfma.2012.11.014
   Singh JA, 2011, CURR OPIN RHEUMATOL, V23, P192, DOI 10.1097/BOR.0b013e3283438e13
   Sirota JC, 2013, METABOLISM, V62, P392, DOI 10.1016/j.metabol.2012.08.013
   Sundy JS, 2011, JAMA-J AM MED ASSOC, V306, P711, DOI [10.1001/jama.2011.116, 10.1001/jama.2011.1169]
   Szabo G, 2012, J HEPATOL, V57, P642, DOI 10.1016/j.jhep.2012.03.035
   Tarantino G, 2013, WORLD J GASTROENTERO, V19, P3375, DOI 10.3748/wjg.v19.i22.3375
   Tarantino G, 2009, EUR J GASTROEN HEPAT, V21, P504, DOI 10.1097/MEG.0b013e3283229b40
   Targher G, 2010, NEW ENGL J MED, V363, P1341, DOI 10.1056/NEJMra0912063
   Tilg H, 2010, HEPATOLOGY, V52, P1836, DOI 10.1002/hep.24001
   Tsouli SG, 2006, METABOLISM, V55, P1293, DOI 10.1016/j.metabol.2006.05.013
   Wang W, 2013, BRIT J PHARMACOL, V169, P1352, DOI 10.1111/bph.12226
   Witek RP, 2009, HEPATOLOGY, V50, P1421, DOI 10.1002/hep.23167
   Wu SJ, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000000802
   Xie YL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0067152
   Xu C, 2015, J HEPATOL
   Xu CF, 2010, HEPATOLOGY, V52, P1865, DOI 10.1002/hep.23798
   Xu CF, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011578
   Ye J, 2009, INT J OBESITY, V33, P54, DOI 10.1038/ijo.2008.229
   Yoo TW, 2005, CIRC J, V69, P928, DOI 10.1253/circj.69.928
   Zhang X, 2015, ANTIOXID REDOX SIGN, V22, P848, DOI 10.1089/ars.2014.5868
   Zhu X, 2009, TRANSPL P, V41, P3736, DOI 10.1016/j.transproceed.2009.06.225
NR 84
TC 26
Z9 29
U1 0
U2 29
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1472-8222
EI 1744-7631
J9 EXPERT OPIN THER TAR
JI Expert Opin. Ther. Targets
PD MAR 3
PY 2016
VL 20
IS 3
BP 375
EP 387
DI 10.1517/14728222.2016.1096930
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DD8GV
UT WOS:000370165100001
PM 26419119
DA 2025-06-11
ER

PT J
AU Tükel, HC
   Alptekin, Ö
   Turan, B
   Delilbasi, E
AF Tukel, H. Can
   Alptekin, Ozlem
   Turan, Belma
   Delilbasi, Ertan
TI Effects of metabolic syndrome on masseter muscle of male Wistar rats
SO EUROPEAN JOURNAL OF ORAL SCIENCES
LA English
DT Article
DE ATPases; masseter muscle; metabolic syndrome; superoxide dismutase;
   trace elements
ID OXIDATIVE STRESS; LIPID-PEROXIDATION; INSULIN-RESISTANCE;
   SKELETAL-MUSCLE; TRACE-ELEMENTS; DIABETES-MELLITUS; REACTIVE OXYGEN;
   NITRIC-OXIDE; DAMAGE; DIET
AB The aim of this study was to investigate the association between metabolic syndrome (MetS) and the metabolic indicators of masticatory muscles in an animal model. A total of 16 male Wistar rats were used. To induce MetS, 10 rats were fed with standard rat chow and 32% sucrose solution ad libitum for 16 wk. Six rats fed with standard rat chow and water ad libitum formed the control group. All rats were killed at week 16, and the right superficial masseter muscles were harvested. Metabolic indicators of masticatory muscle metabolism, including antioxidant enzyme activities, ion transport ATPase activities, and the levels of macro and trace elements, were determined in the muscles. Superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activities were significantly decreased by 32%, 26%, 33%, and 16%, respectively, in the MetS group. Na+/K+-ATPase activity was significantly decreased in the MetS group by 54% compared with the control group. The levels of chromium and selenium were significantly decreased, and the level of copper was increased, in the MetS group compared with the control group. These results show that significant alterations occurred in antioxidant defense mechanisms, ion transport mechanisms, and trace element levels of masseter muscles in MetS.
C1 [Tukel, H. Can] Cukurova Univ, Dept Oral & Maxillofacial Surg, Fac Dent, TR-01330 Adana, Turkey.
   [Alptekin, Ozlem] Cukurova Univ, Dept Biochem, Fac Pharm, TR-01330 Adana, Turkey.
   [Turan, Belma] Ankara Univ, Dept Biophys, Fac Med, TR-06100 Ankara, Turkey.
   [Delilbasi, Ertan] Gazi Univ, Dept Oral & Maxillofacial Surg, Fac Dent, Ankara, Turkey.
C3 Cukurova University; Cukurova University; Ankara University; Gazi
   University
RP Tükel, HC (corresponding author), Cukurova Univ, Dept Oral & Maxillofacial Surg, Fac Dent, TR-01330 Adana, Turkey.
EM ctukel@cu.edu.tr
RI TURAN, Belma/AAG-8084-2020; Alptekin, Ozlem/A-3233-2016; tukel, huseyin
   can/J-9250-2018
OI TURAN, Belma/0000-0003-2583-9294; Alptekin, Ozlem/0000-0002-0458-7609;
   tukel, huseyin can/0000-0002-6723-0842
CR AEBI H, 1984, METHOD ENZYMOL, V105, P121
   Aghabeigi B, 1997, BRIT J ORAL MAX SURG, V35, P161, DOI 10.1016/S0266-4356(97)90555-6
   Allen DG, 2004, CLIN EXP PHARMACOL P, V31, P485, DOI 10.1111/j.1440-1681.2004.04032.x
   [Anonymous], CURR RES CARDIOL
   [Anonymous], CAN J PHYSL PHARM
   ATKINSON A, 1973, BIOCHIM BIOPHYS ACTA, V320, P195, DOI 10.1016/0304-4165(73)90178-5
   Balderas-Villalobos J, 2013, AM J PHYSIOL-HEART C, V305, pH1344, DOI 10.1152/ajpheart.00211.2013
   Beevi SSS, 2004, JPN J CLIN ONCOL, V34, P379, DOI 10.1093/jjco/hyh058
   BROWN MR, 1986, AM J CLIN NUTR, V43, P549, DOI 10.1093/ajcn/43.4.549
   Callahan LA, 2001, J APPL PHYSIOL, V90, P45, DOI 10.1152/jappl.2001.90.1.45
   Cameron AJ, 2004, ENDOCRIN METAB CLIN, V33, P351, DOI 10.1016/j.ecl.2004.03.005
   CARLBERG I, 1975, J BIOL CHEM, V250, P5475
   Choi WS, 2014, BIOL TRACE ELEM RES, V158, P323, DOI 10.1007/s12011-014-9946-2
   Dahiya Parveen, 2013, J Indian Soc Periodontol, V17, P411, DOI 10.4103/0972-124X.118306
   de Lima ACB, 2013, J ETHNOPHARMACOL, V146, P192, DOI 10.1016/j.jep.2012.12.031
   Djurhuus MS, 2001, J CLIN ENDOCR METAB, V86, P859, DOI 10.1210/jc.86.2.859
   Ekmekcioglu C, 2001, BIOL TRACE ELEM RES, V79, P205, DOI 10.1385/BTER:79:3:205
   El-Arab AE, 2014, ARAB J NUCL SCI APPL, V47, P201
   Etoz OA, 2009, INT J NEUROSCI, V119, P1282, DOI 10.1080/00207450902907482
   Evans JL, 2005, ANTIOXID REDOX SIGN, V7, P1040, DOI 10.1089/ars.2005.7.1040
   Fulle S, 2000, FREE RADICAL BIO MED, V29, P1252, DOI 10.1016/S0891-5849(00)00419-6
   Ghayour-Mobarhan M., 2008, Pakistan Journal of Nutrition, V7, P112
   Ghosh S, 2011, J BIOL CHEM, V286, P42483, DOI 10.1074/jbc.M111.304592
   Green HJ, 2004, CAN J APPL PHYSIOL, V29, P291, DOI 10.1139/h04-020
   HABIG WH, 1974, J BIOL CHEM, V249, P7130
   Han DS, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0108230
   HUNT JV, 1988, BIOCHEM J, V256, P205, DOI 10.1042/bj2560205
   Jammes Y, 2005, J INTERN MED, V257, P299, DOI 10.1111/j.1365-2796.2005.01452.x
   Javorková V, 2010, GEN PHYSIOL BIOPHYS, V29, P266, DOI 10.4149/gpb_2010_03_266
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   KJELDSEN K, 1987, DIABETES, V36, P842, DOI 10.2337/diabetes.36.7.842
   LEE CI, 1995, JPN J PHARMACOL, V67, P21, DOI 10.1254/jjp.67.21
   Lee MC, 2004, REDOX REP, V9, P331, DOI 10.1179/135100004225006830
   Li Q, 2011, PHYSIOL BEHAV, V104, P365, DOI 10.1016/j.physbeh.2011.04.012
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   Mansour S.M., 2013, B FAC PHARM CAIRO, V51, P13, DOI [10.1016/J.BFOPCU.2012.10.001, DOI 10.1016/J.BFOPCU.2012.10.001]
   MIYATA H, 1993, ANAT RECORD, V237, P415, DOI 10.1002/ar.1092370315
   Ozgocmen S, 2006, RHEUMATOL INT, V26, P598, DOI 10.1007/s00296-005-0079-y
   PAGLIA DE, 1967, J LAB CLIN MED, V70, P158
   Pizent A, 2010, J NUTR HEALTH AGING, V14, P866, DOI 10.1007/s12603-010-0139-1
   Reddy SS, 2009, FOOD CHEM TOXICOL, V47, P2224, DOI 10.1016/j.fct.2009.06.008
   REID MB, 1992, J APPL PHYSIOL, V73, P1805, DOI 10.1152/jappl.1992.73.5.1805
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Rodrigo R, 2007, MOL CELL BIOCHEM, V303, P73, DOI 10.1007/s11010-007-9457-y
   Russell AP, 2003, FEBS LETT, V551, P104, DOI 10.1016/S0014-5793(03)00875-5
   Sánchez GA, 2014, EUR J ORAL SCI, V122, P36, DOI 10.1111/eos.12098
   Siddiqui K, 2014, SCI WORLD J, DOI 10.1155/2014/461591
   SUN Y, 1988, CLIN CHEM, V34, P497
   Vasanji Z, 2006, AM J PHYSIOL-CELL PH, V291, pC772, DOI 10.1152/ajpcell.00086.2005
   Viggiano A, 2005, BRAIN RES, V1050, P72, DOI 10.1016/j.brainres.2005.05.021
   Willey KA, 2003, DIABETES CARE, V26, P1580, DOI 10.2337/diacare.26.5.1580
NR 51
TC 3
Z9 3
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0909-8836
EI 1600-0722
J9 EUR J ORAL SCI
JI Eur. J. Oral Sci.
PD DEC
PY 2015
VL 123
IS 6
BP 432
EP 438
DI 10.1111/eos.12226
PG 7
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA CX5RJ
UT WOS:000365759800008
PM 26521868
DA 2025-06-11
ER

PT J
AU Mehra, S
   Kapur, S
   Mittal, S
   Sehgal, PK
AF Mehra, Shipra
   Kapur, Suman
   Mittal, Saumyaa
   Sehgal, Pramod Kumar
TI Common genetic link between metabolic syndrome components and senile
   cataract
SO FREE RADICAL RESEARCH
LA English
DT Article
DE D2S439; SPHKAP gene; MDA levels; visceral adiposity; metabolic syndrome
ID AGE-RELATED CATARACT; HUMAN OBESITY; RISK-FACTORS; POPULATION; FAT; SCAN
AB Relationship between cataract and metabolic syndrome (MetS) is well established, but genetic link remains to be explored. D2S439 at 2q37 linked with QTL controlling visceral fat was investigated for its association with senile cataract. Two hundred and twenty-seven subjects including 119 cataract cases were genotyped for D2S439, tetra nucleotide repeat marker. Statistical tools assessed the association of marker's allele with anthropometric, clinical and oxidation stress parameters. Cases with longer allele >= (CTAT)(12) repeats, differed significantly from controls (0.77 vs. 0.58, p < 0.0001). Cases with at least one longer allele had higher waist circumference (50% vs. 15%, p = 0.0090), hyper-triglyceridemia (28% vs. 11%), hypo-HDL cholesterolemia (80% vs. 74%) and high diastolic blood pressure (37% vs. 26%) when compared to cases bearing the shorter allele. Cataract subjects with at least one longer allele had significantly raised lipid peroxidation levels (p = 0.0095) and showed an increased risk for cataract (OR = -5.86, CI95% = 1.49-23.11, p = 0.0114) after controlling for dependent variables. This exploratory study suggests that presence of even a single longer allele of D2S439 is associated with both cataract and MetS components in Asian Indians, unraveling the existence of a shared genetic locus.
C1 [Kapur, Suman] Birla Inst Technol & Sci Pilani, Dept Biol Sci, Hyderabad 500078, Andhra Pradesh, India.
   [Sehgal, Pramod Kumar] Mahadev Singhi Eye Hosp, Pilani, Rajasthan, India.
   [Mittal, Saumyaa] Uniform Serv Univ Hlth Sci, Bethesda, MD USA.
C3 Birla Institute of Technology & Science Pilani (BITS Pilani)
RP Kapur, S (corresponding author), Birla Inst Technol & Sci Pilani, Dept Biol Sci, Hyderabad Campus, Hyderabad 500078, Andhra Pradesh, India.
EM kapur@bits-pilani.ac.in
FU Indian Council of Medical Research, Government of India; Indian Council
   of Medical Research, New Delhi; ICMR
FX This work was supported, in part, by grants from Indian Council of
   Medical Research, Government of India. The study was supported by funds
   in the form of extramural grants from Indian Council of Medical
   Research, New Delhi to Dr. Suman Kapur and Senior research fellowship
   from ICMR to Mrs. Shipra Mehra. No conflict of interest exists between
   authors. The authors alone are responsible for the content and writing
   of the paper.
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Borchman D, 2010, J LIPID RES, V51, P2473, DOI 10.1194/jlr.R004119
   Cheung N, 2007, SURV OPHTHALMOL, V52, P180, DOI 10.1016/j.survophthal.2006.12.003
   CHYLACK LT, 1993, ARCH OPHTHALMOL-CHIC, V111, P831, DOI 10.1001/archopht.1993.01090060119035
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Congdon N, 2004, INVEST OPHTH VIS SCI, V45, P2182, DOI 10.1167/iovs.03-1163
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Diviani D, 2001, J CELL SCI, V114, P1431
   Enas Enas A, 2007, J Cardiometab Syndr, V2, P267, DOI 10.1111/j.1559-4564.2007.07392.x
   Galeone C, 2010, ANN EPIDEMIOL, V20, P380, DOI 10.1016/j.annepidem.2010.01.009
   Hmani-Aifa M, 2009, HUM GENET, V126, P575, DOI 10.1007/s00439-009-0688-8
   Hopps E, 2010, NUTR METAB CARDIOVAS, V20, P72, DOI 10.1016/j.numecd.2009.06.002
   Huang L, 2005, INVEST OPHTH VIS SCI, V46, P1682, DOI 10.1167/iovs.04-1155
   Iyengar SK, 2004, P NATL ACAD SCI USA, V101, P14485, DOI 10.1073/pnas.0400778101
   Jiao XD, 2004, INVEST OPHTH VIS SCI, V45, P4498, DOI 10.1167/iovs.04-0722
   Kapoor M, 2009, DEPRESS ANXIETY, V26, P791, DOI 10.1002/da.20570
   Kapur S, 2009, INDIAN J OPHTHALMOL, V57, P197, DOI 10.4103/0301-4738.49393
   Kisic B, 2009, VOJNOSANIT PREGL, V66, P371, DOI 10.2298/VSP0905371K
   Kolosova NG, 2004, B EXP BIOL MED+, V137, P249, DOI 10.1023/B:BEBM.0000031561.71977.85
   Lee JH, 1999, AM J HUM GENET, V64, P196, DOI 10.1086/302195
   Lim LS, 2009, AM J EPIDEMIOL, V169, P1267, DOI 10.1093/aje/kwp045
   Maddala R, 2003, INVEST OPHTH VIS SCI, V44, P1256
   Mangat C, 2010, DIABETOL METAB SYNDR, V2, DOI 10.1186/1758-5996-2-19
   Misra A, 2008, J CLIN ENDOCR METAB, V93, pS9, DOI 10.1210/jc.2008-1595
   Nirmalan PK, 2004, BRIT J OPHTHALMOL, V88, P989, DOI 10.1136/bjo.2003.038380
   Pchejetski D, 2007, CIRC RES, V100, P41, DOI 10.1161/01.RES.0000253900.66640.34
   Pérusse L, 2005, OBES RES, V13, P381, DOI 10.1038/oby.2005.50
   Praveen MR, 2010, EYE, V24, P686, DOI 10.1038/eye.2009.137
   Rice T, 2002, DIABETES, V51, P848, DOI 10.2337/diabetes.51.3.848
   Sabanayagam C, 2011, INVEST OPHTHALMOL VI
   Sabanayagam C, 2011, INVEST OPHTH VIS SCI, V52, P2397, DOI 10.1167/iovs.10-6373
   Sandeep S, 2010, INDIAN J MED RES, V131, P629
   Schaumberg DA, 2000, AM J CLIN NUTR, V72, P1495
   Takuwa N, 2010, CARDIOVASC RES, V85, P484, DOI 10.1093/cvr/cvp312
   Tang WH, 2003, DIABETES, V52, P2840, DOI 10.2337/diabetes.52.11.2840
   VALENZUELA A, 1991, LIFE SCI, V48, P301, DOI 10.1016/0024-3205(91)90550-U
   Viswanathan M., 2006, Diabetis and metabolic syndrome, V51, P15
NR 37
TC 3
Z9 3
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PD FEB
PY 2012
VL 46
IS 2
BP 133
EP 140
DI 10.3109/10715762.2011.645205
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 884ZS
UT WOS:000299748000003
PM 22165987
DA 2025-06-11
ER

PT J
AU Luo, T
   Snyder, SM
   Zhao, BX
   Sullivan, DK
   Hamilton-Reeves, J
   Guthrie, G
   Ricketts, ML
   Shiverick, KT
   Shay, N
AF Luo, Ting
   Snyder, Sarah M.
   Zhao, Bingxin
   Sullivan, Debra K.
   Hamilton-Reeves, Jill
   Guthrie, Gregory
   Ricketts, Marie-Louise
   Shiverick, Kathleen T.
   Shay, Neil
TI Gene Expression Patterns Are Altered in Athymic Mice and Metabolic
   Syndrome Factors Are Reduced in C57BL/6J Mice Fed High-Fat Diets
   Supplemented with Soy Isoflavones
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE metabolic syndrome; isoflavones; genistein; oxidation; inflammation;
   lipid metabolism
ID ACTIVATED RECEPTOR-ALPHA; LIVER-DISEASE; PEROXISOME PROLIFERATOR;
   INSULIN-RESISTANCE; POSTMENOPAUSAL WOMEN; PROSTATE-CANCER;
   BLOOD-GLUCOSE; IN-VITRO; GENISTEIN; METAANALYSIS
AB Soy isoflavones exert beneficial health effects; however, their potential to ameliorate conditions associated with the metabolic syndrome (MetS) has not been studied in detail. In vitro and in vivo models were used to determine the effect of isoflavones on lipid metabolism, inflammation, and oxidative stress. In nude mice, consumption of Novasoy (NS) increased cholesterol and lipid metabolism gene expression, including Scd-1 (27.7-fold), Cyp4a14 (35.2-fold), and Cyp4a10 (9.5-fold), and reduced anti-inflammatory genes, including Cebpd (16.4-fold). A high-fat (HF) diet containing 0.4% (w/w) NS for 10 weeks significantly reduced percent weight gain (74.6 +/- 2.5 vs 68.6 +/- 3.5%) and hepatic lipid accumulation (20 +/- 1.2 vs 27 +/- 1.5%), compared to HF alone (p < 0.05) in C57BL/6J mice. NS also increased lipid oxidation and antioxidant gene expression while decreasing inflammatory cytokines. In vitro analysis in HepG2 cells revealed that genistein dose-dependently decreases oleic acid induced lipid accumulation. Soy isoflavones may ameliorate symptoms associated with MetS via anti-inflammatory, antioxidant, and hypolipidemic modulation.
C1 [Luo, Ting; Snyder, Sarah M.; Zhao, Bingxin; Shay, Neil] Oregon State Univ, Food Sci & Technol, Corvallis, OR 97330 USA.
   [Sullivan, Debra K.; Hamilton-Reeves, Jill] Kansas Univ, Dietet & Nutr, Med Ctr, Kansas City, KS 66160 USA.
   [Guthrie, Gregory] Baylor Coll Med, Houston, TX 77030 USA.
   [Ricketts, Marie-Louise] Univ Nevada, Agr Nutr & Vet Sci, Reno, NV 89557 USA.
   [Shiverick, Kathleen T.] Univ Florida, Coll Med, Pharmacol, Gainesville, FL 32610 USA.
C3 Oregon State University; University of Kansas; University of Kansas
   Medical Center; Baylor College of Medicine; Nevada System of Higher
   Education (NSHE); University of Nevada Reno; State University System of
   Florida; University of Florida
RP Shay, N (corresponding author), Dept Food Sci & Technol, 202 Wiegand Hall,3051 SW Campus Way, Corvallis, OR 97330 USA.
EM neil.shay@oregonstate.edu
RI Luo, Ting/O-7773-2019; Ricketts, Marie/LDG-8176-2024; Guthrie,
   Gregory/ABI-4949-2022
OI Ricketts, Marie-Louise/0000-0002-8306-7563
CR ADLERCREUTZ H, 1993, LANCET, V342, P1209, DOI 10.1016/0140-6736(93)92188-Y
   Andrikopoulos S, 2008, AM J PHYSIOL-ENDOC M, V295, pE1323, DOI 10.1152/ajpendo.90617.2008
   Ayala JE, 2006, DIABETES, V55, P390, DOI 10.2337/diabetes.55.02.06.db05-0686
   Ayala JE, 2010, DIS MODEL MECH, V3, P525, DOI 10.1242/dmm.006239
   Azuma K, 2003, OBES RES, V11, P997, DOI 10.1038/oby.2003.137
   Baker RG, 2011, CELL METAB, V13, P11, DOI 10.1016/j.cmet.2010.12.008
   Banerjee RR, 2004, SCIENCE, V303, P1195, DOI 10.1126/science.1092341
   Bloedon LT, 2002, AM J CLIN NUTR, V76, P1126, DOI 10.1093/ajcn/76.5.1126
   Cho KW, 2010, J NUTR BIOCHEM, V21, P841, DOI 10.1016/j.jnutbio.2009.06.012
   Christiansen T, 2005, INT J OBESITY, V29, P146, DOI 10.1038/sj.ijo.0802839
   Clarkson TB, 2002, J NUTR, V132, p566S, DOI 10.1093/jn/132.3.566S
   Ding J, 2013, CELL REP, V5, P248, DOI 10.1016/j.celrep.2013.08.032
   Fotakis G, 2006, TOXICOL LETT, V160, P171, DOI 10.1016/j.toxlet.2005.07.001
   Frid AH, 2005, AM J CLIN NUTR, V82, P69, DOI 10.1093/ajcn/82.1.69
   Friedman JM, 2003, SCIENCE, V299, P856, DOI 10.1126/science.1079856
   Gao Y, 2015, J AGR FOOD CHEM, V63, P9696, DOI 10.1021/acs.jafc.5b03957
   Guadamuro L, 2016, J AGR FOOD CHEM, V64, P210, DOI 10.1021/acs.jafc.5b05102
   Heinonen Satu-Maarit, 2002, Phytochemistry Reviews, V1, P175, DOI 10.1023/A:1022555216303
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Jeon S, 2014, MOL NUTR FOOD RES, V58, P830, DOI 10.1002/mnfr.201300112
   Jung JH, 2013, FOOD CHEM TOXICOL, V60, P404, DOI 10.1016/j.fct.2013.07.048
   Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2548, DOI 10.1210/jc.2004-0395
   Kim EH, 2012, J AGR FOOD CHEM, V60, P6045, DOI 10.1021/jf300463f
   King RA, 1998, AM J CLIN NUTR, V67, P867, DOI 10.1093/ajcn/67.5.867
   Lee JY, 2011, BIOCHEM BIOPH RES CO, V407, P818, DOI 10.1016/j.bbrc.2011.03.106
   Li Y, 2007, J NUTR, V137, P1705, DOI 10.1093/jn/137.7.1705
   Li YL, 2009, J NUTR, V139, P898, DOI 10.3945/jn.108.103572
   Liu YX, 2011, J AGR FOOD CHEM, V59, P12254, DOI 10.1021/jf203136j
   Messina M, 2009, NUTR CANCER, V61, P792, DOI 10.1080/01635580903285015
   Meyer K, 2003, CARCINOGENESIS, V24, P975, DOI 10.1093/carcin/bgg040
   Mezei O, 2006, PHYSIOL GENOMICS, V26, P8, DOI 10.1152/physiolgenomics.00155.2005
   Miltyk W, 2003, AM J CLIN NUTR, V77, P875, DOI 10.1093/ajcn/77.4.875
   Monzillo LU, 2003, OBES RES, V11, P1048, DOI 10.1038/oby.2003.144
   Mozumdar A, 2011, DIABETES CARE, V34, P216, DOI 10.2337/dc10-0879
   NOMURA H, 1988, JPN J MED, V27, P142, DOI 10.2169/internalmedicine1962.27.142
   Okada K, 2013, J GASTROENTEROL, V48, P620, DOI 10.1007/s00535-012-0659-z
   Pan W, 2001, J NUTR, V131, P1154, DOI 10.1093/jn/131.4.1154
   Peters JM, 2005, J MOL MED-JMM, V83, P774, DOI 10.1007/s00109-005-0678-9
   PRESTERA T, 1995, MOL MED, V1, P827, DOI 10.1007/BF03401897
   Qiu LX, 2015, WORLD J GASTROENTERO, V21, P1099, DOI 10.3748/wjg.v21.i4.1099
   Rajala MW, 2003, J CLIN INVEST, V111, P225, DOI 10.1172/JCI200316521
   RAMIREZZACARIAS JL, 1992, HISTOCHEMISTRY, V97, P493, DOI 10.1007/BF00316069
   Reagan-Shaw S, 2008, FASEB J, V22, P659, DOI 10.1096/fj.07-9574LSF
   Rice L, 2007, J NUTR, V137, P964, DOI 10.1093/jn/137.4.964
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Shay N. F., 2010, FASEB J, V24, P924
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Siri-Tarino PW, 2010, AM J CLIN NUTR, V91, P535, DOI 10.3945/ajcn.2009.27725
   Smith SR, 2003, DIABETES, V52, P1611, DOI 10.2337/diabetes.52.7.1611
   Steppan CM, 2001, NATURE, V409, P307, DOI 10.1038/35053000
   Tang CH, 2015, J AGR FOOD CHEM, V63, P7929, DOI 10.1021/acs.jafc.5b01590
   Tiniakos DG, 2010, ANNU REV PATHOL-MECH, V5, P145, DOI 10.1146/annurev-pathol-121808-102132
   Toro-Funes N, 2015, FOOD FUNCT, V6, P98, DOI 10.1039/c4fo00772g
   Unger RH, 2002, ANNU REV MED, V53, P319, DOI 10.1146/annurev.med.53.082901.104057
   Yan L, 2010, CANCER EPIDEM BIOMAR, V19, P148, DOI 10.1158/1055-9965.EPI-09-0856
   Yang Y, 2009, BIOMED PHARMACOTHER, V63, P366, DOI 10.1016/j.biopha.2008.06.033
   Zhang YB, 2013, NUTRITION, V29, P8, DOI 10.1016/j.nut.2012.03.019
   Zivkovic AM, 2007, AM J CLIN NUTR, V86, P285, DOI 10.1093/ajcn/86.2.285
NR 58
TC 13
Z9 13
U1 2
U2 15
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD OCT 12
PY 2016
VL 64
IS 40
BP 7492
EP 7501
DI 10.1021/acs.jafc.6b03401
PG 10
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA DY9QJ
UT WOS:000385469900010
PM 27653593
DA 2025-06-11
ER

PT J
AU Tian, FS
   Luo, R
   Zhao, ZQ
   Wu, Y
   Ban, DJ
AF Tian, F. S.
   Luo, R.
   Zhao, Z. Q.
   Wu, Y.
   Ban, D. J.
TI Blockade of the RAS increases Plasma Adiponectin in Subjects with
   Metabolic Syndrome and Enhances Differentiation and Adiponectin
   Expression of Human Preadipocytes
SO EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
LA English
DT Article
DE renin-angiotensin system; preadipocytes; metabolic syndrome; cell
   differentiation; adiponectin
ID RENIN-ANGIOTENSIN SYSTEM; ADIPOSE-TISSUE; PPAR-GAMMA; OXIDATIVE STRESS;
   ADIPOCYTES; HYPERTENSION; TELMISARTAN; INHIBITION; RECEPTORS; INDUCTION
AB This observational study aimed to investigate the effects of renin-angiotensin system (RAS) blockers on plasma adiponectin in subjects with metabolic syndrome (Mets) and differentiation, adiponectin expression of human omental (OM) and subcutaneous (SC) preadipocytes.
   Fifty-three patients with Mets were treated with angiotensin converting enzyme inhibition (ACEI), angiotensin II receptor blocker (ARB) or nothing, lipid profile and adiponetin were measured. OM and SC preadipocytes were obtained from sixteen normal non-menopausal women undergoing elective abdominal surgery and subsequently differentiated in the presence of ACE, ARB or thiazolidinedione (TZD). Differentiation was assessed using a number of biochemical and function parameters.
   Plasma adiponectin was increased dramatically as a result of ACEI and ARB treatment. Most of the metabolic and differentiating parameters were improved significantly by RAS blockers or TZD. Compared with TZD, RAS blockers have stronger effects on omental preadipocytes in differentiation and insulin sensitivity. The improvement of adiponectin mRNA expression was significantly greater in ARB-treated omental preadipocytes compared with TZD-treated ones.
   These results suggest that adiponectin may serve as potential therapeutic targets of ACEI and ARB for treating the Mets and its related complications. It also suggests a potential benefit of RAS blockers on Mets with characteristic visceral obesity.
C1 Tianjin Gong An Hosp, Dept Med, Tianjin, Peoples R China.
   Tianjin Gong An Hosp, Dept Surg, Tianjin, Peoples R China.
RP Luo, R (corresponding author), 78 Nanjing Rd, Tianjin 300042, Peoples R China.
EM starelr_99@126.com
CR Adams M, 1997, J CLIN INVEST, V100, P3149, DOI 10.1172/JCI119870
   Arita Y, 1999, BIOCHEM BIOPH RES CO, V257, P79, DOI 10.1006/bbrc.1999.0255
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Clasen R, 2005, HYPERTENSION, V46, P137, DOI 10.1161/01.HYP.0000168046.19884.6a
   Dahlöf B, 2002, LANCET, V359, P995, DOI 10.1016/S0140-6736(02)08089-3
   Dai MH, 2006, DOMEST ANIM ENDOCRIN, V30, P117, DOI 10.1016/j.domaniend.2005.06.006
   Derosa G, 2007, J CLIN PHARM THER, V32, P261, DOI 10.1111/j.1365-2710.2007.00820.x
   Erbe DV, 2006, VASC PHARMACOL, V45, P154, DOI 10.1016/j.vph.2006.05.002
   Fain JN, 2004, ENDOCRINOLOGY, V145, P2273, DOI 10.1210/en.2003-1336
   Francke S, 2001, HUM MOL GENET, V10, P2751, DOI 10.1093/hmg/10.24.2751
   Furuhashi M, 2003, HYPERTENSION, V42, P76, DOI 10.1161/01.HYP.0000078490.59735.6E
   Giacchetti G, 2002, AM J HYPERTENS, V15, P381, DOI 10.1016/S0895-7061(02)02257-4
   Goossens G H, 2003, Obes Rev, V4, P43
   HARMELEN V, 2000, INT J OBESITY, V24, P673
   Hattori Y, 2005, DIABETOLOGIA, V48, P1066, DOI 10.1007/s00125-005-1766-7
   Hsu CL, 2007, J AGR FOOD CHEM, V55, P1730, DOI 10.1021/jf062912b
   Iwaki M, 2003, DIABETES, V52, P1655, DOI 10.2337/diabetes.52.7.1655
   Janke J, 2002, DIABETES, V51, P1699, DOI 10.2337/diabetes.51.6.1699
   Karagiannis A, 2007, EXPERT OPIN THER TAR, V11, P191, DOI 10.1517/14728222.11.2.191
   Katsuki A, 2006, DIABETES RES CLIN PR, V73, P310, DOI 10.1016/j.diabres.2006.02.014
   Kim S, 2006, J BIOMED BIOTECHNOL, DOI 10.1155/JBB/2006/27012
   Kurata A, 2006, KIDNEY INT, V70, P1717, DOI 10.1038/sj.ki.5001810
   Lely AT, 2007, J CLIN ENDOCR METAB, V92, P1821, DOI 10.1210/jc.2006-2092
   Lu Yan-hui, 2006, Zhonghua Yi Xue Za Zhi, V86, P386
   Mori Y, 2007, AM J HYPERTENS, V20, P431, DOI 10.1016/j.amjhyper.2006.09.016
   Moriuchi A, 2007, BIOCHEM BIOPH RES CO, V356, P1024, DOI 10.1016/j.bbrc.2007.03.084
   Negro R, 2006, J ENDOCRINOL INVEST, V29, P957, DOI 10.1007/BF03349207
   Nishida M, 2007, CIRC J, V71, P1234, DOI 10.1253/circj.71.1234
   Nishizawa H, 2002, DIABETES, V51, P2734, DOI 10.2337/diabetes.51.9.2734
   Quinkler M, 2006, GENE, V380, P137, DOI 10.1016/j.gene.2006.05.026
   Rahmouni K, 2004, AM J PHYSIOL-ENDOC M, V286, pE891, DOI 10.1152/ajpendo.00551.2003
   Schupp M, 2004, CIRCULATION, V109, P2054, DOI 10.1161/01.CIR.0000127955.36250.65
   Sewter CP, 2002, DIABETES, V51, P718, DOI 10.2337/diabetes.51.3.718
   Wang BH, 2005, AM J PHYSIOL-ENDOC M, V288, pE731, DOI 10.1152/ajpendo.00475.2004
   Zorad S, 2006, EUR J PHARMACOL, V552, P112, DOI 10.1016/j.ejphar.2006.08.062
NR 35
TC 26
Z9 33
U1 0
U2 1
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0947-7349
EI 1439-3646
J9 EXP CLIN ENDOCR DIAB
JI Exp. Clin. Endocrinol. Diabet.
PD APR
PY 2010
VL 118
IS 4
BP 258
EP 265
DI 10.1055/s-0029-1237706
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 590VZ
UT WOS:000277257700009
PM 19856251
DA 2025-06-11
ER

PT J
AU Lapinska, L
   Krentowska, A
   Kondraciuk, M
   Chlabicz, M
   Waszkiewicz, N
   Kaminski, K
   Kowalska, I
AF Lapinska, Lidia
   Krentowska, Anna
   Kondraciuk, Marcin
   Chlabicz, Malgorzata
   Waszkiewicz, Napoleon
   Kaminski, Karol
   Kowalska, Irina
TI The association between plasma N-terminal pro-brain natriuretic peptide
   concentration and metabolic disturbances in women with depressive
   symptoms
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Depressive symptoms; NT-proBNP; Insulin resistance; Metabolic syndrome
ID HEART
AB Background: The relationship between brain natriuretic peptides and depression was studied in patients with cardiovascular diseases (CVD), but the data in people without CVD are limited. Metabolic disturbances can be associated with natriuretic peptides' levels. The study aimed to assess serum N-terminal pro-brain natriuretic peptide (NT-proBNP) level in women with depressive symptoms and its relationship with metabolic disturbances.Methods: The analysis included 347 women (20-60 years old) from Bialystok PLUS cohort study: 98 with depressive symptoms and 249 controls. Clinical examination, oral glucose tolerance test (OGTT) and assessment of lipid, sex hormone binding globulin (SHBG) and NT-proBNP concentrations in the blood were performed. The participants completed Beck Depression Inventory questionnaire.Results: Metabolic syndrome was more frequent in the group of women with depressive symptoms compared to women without depressive symptoms. Women with depressive symptoms had lower NT-proBNP level than the control group -45.88 (27.80-67.04) vs 56.49 (32.42-94.25) pg/mL, p = 0.027. Multiple linear regression analysis of all women showed that NT-proBNP level was reversely associated with the presence of depressive symptoms, waist circumference and heart rate and positively connected with age. In the group of women with depressive symptoms, we observed negative correlations between NT-proBNP level and insulin concentration at 60 min of OGTT, diastolic blood pressure and a positive correlation with SHBG.Conclusions: NT-proBNP level is decreased in women with depressive symptoms, which might be connected with metabolic disturbances in this group.
C1 [Lapinska, Lidia; Krentowska, Anna; Kowalska, Irina] Med Univ Bialystok, Dept Internal Med & Metab Dis, Bialystok, Poland.
   [Kondraciuk, Marcin] Med Univ Bialystok, Populat Res Ctr, Bialystok, Poland.
   [Chlabicz, Malgorzata; Kaminski, Karol] Med Univ Bialystok, Dept Populat Med & Lifestyle Dis Prevent, Bialystok, Poland.
   [Waszkiewicz, Napoleon] Med Univ Bialystok, Dept Psychiat, Bialystok, Poland.
   [Lapinska, Lidia] Med Univ Bialystok, Dept Internal Med & Metab Dis, M Sklodowskiej Curie 24a, PL-15276 Bialystok, Poland.
C3 Medical University of Bialystok; Medical University of Bialystok;
   Medical University of Bialystok; Medical University of Bialystok;
   Medical University of Bialystok
RP Lapinska, L (corresponding author), Med Univ Bialystok, Dept Internal Med & Metab Dis, M Sklodowskiej Curie 24a, PL-15276 Bialystok, Poland.
EM lidia.lapinska@umb.edu.pl
RI Kaminski, Karol/J-4515-2014; Chlabicz, Malgorzata/AAZ-9550-2020;
   Waszkiewicz, Napoleon/AAI-5530-2020; Krentowska, Anna/GYU-3703-2022
OI Chlabicz, Malgorzata/0000-0002-5113-5672; Krentowska,
   Anna/0000-0001-5959-5481; Kondraciuk, Marcin/0000-0002-4516-7467
FU Municipal Office in Bialystok [W/UB/DSP/1640/UMBIALYSTOK/2017]; Medical
   University of Bialystok for the Bialystok PLUS study
   [SUB/1/00/19/001/1201]
FX Bialystok PLUS study was supported by the Municipal Office in Bialystok
   (grant Number W/UB/DSP/1640/UMBIA LYSTOK/2017) and from funds from the
   Medical University of Bialystok for the Bialystok PLUS study (grant
   Number SUB/1/00/19/001/1201) .
CR Abdelalim EM, 2006, PEPTIDES, V27, P1886, DOI 10.1016/j.peptides.2006.01.001
   Amir O, 2010, STRESS, V13, P83, DOI 10.3109/10253890902818357
   Baldassarre S, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-017-0601-z
   Biro E, 1996, NEUROPEPTIDES, V30, P59, DOI 10.1016/S0143-4179(96)90056-6
   Chang AY, 2007, J AM COLL CARDIOL, V49, P109, DOI 10.1016/j.jacc.2006.10.040
   Chlabicz M, 2020, J CLIN MED, V9, DOI 10.3390/jcm9010074
   Cosan AS, 2021, BRAIN BEHAV, V11, DOI 10.1002/brb3.1912
   Davis SR, 2015, LANCET DIABETES ENDO, V3, P980, DOI 10.1016/S2213-8587(15)00284-3
   Dedovic K, 2010, BIOL PSYCHIAT, V68, P847, DOI 10.1016/j.biopsych.2010.07.025
   Dobrzycka M, 2022, NUTRIENTS, V14, DOI 10.3390/nu14040837
   Fangauf SV, 2018, PSYCHONEUROENDOCRINO, V96, P188, DOI 10.1016/j.psyneuen.2018.06.001
   Gruden G, 2014, DIABETES CARE, V37, P2899, DOI 10.2337/dc14-0669
   Hodes A, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00201
   James ML, 2010, J NEUROTRAUM, V27, P217, DOI 10.1089/neu.2009.1022
   Jászberényi M, 2000, LIFE SCI, V66, P1655, DOI 10.1016/S0024-3205(00)00485-9
   Kaczmarczyk M, 2019, PSYCHONEUROENDOCRINO, V101, P7, DOI 10.1016/j.psyneuen.2018.10.020
   Kuehner C, 2017, LANCET PSYCHIAT, V4, P146, DOI 10.1016/S2215-0366(16)30263-2
   Lapinska L, 2022, POL ARCH INTERN MED, V132, DOI 10.20452/pamw.16261
   Malhi GS, 2018, LANCET, V392, P2299, DOI 10.1016/S0140-6736(18)31948-2
   Marijnissen RM, 2013, J AFFECT DISORDERS, V151, P1138, DOI 10.1016/j.jad.2013.07.029
   Meyer T, 2017, VITAM HORM, V103, P131, DOI 10.1016/bs.vh.2016.08.002
   Müller-Tasch T, 2021, J PSYCHOSOM RES, V143, DOI 10.1016/j.jpsychores.2021.110385
   Obokata M, 2017, CIRCULATION, V136, P6, DOI 10.1161/CIRCULATIONAHA.116.026807
   Olsen MH, 2005, HYPERTENSION, V46, P660, DOI 10.1161/01.HYP.0000179575.13739.72
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pariante CM, 2017, EUR NEUROPSYCHOPHARM, V27, P554, DOI 10.1016/j.euroneuro.2017.04.001
   Politi P, 2007, NEUROSCI LETT, V417, P322, DOI 10.1016/j.neulet.2007.02.056
   Porzionato A, 2010, INT REV CEL MOL BIO, V280, P1, DOI 10.1016/S1937-6448(10)80001-2
   Simons PIHG, 2023, DIABETOLOGIA, V66, P213, DOI 10.1007/s00125-022-05790-7
   Smith U, 2015, J CLIN INVEST, V125, P1790, DOI 10.1172/JCI81507
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Yamagata H, 2018, J AFFECT DISORDERS, V233, P79, DOI 10.1016/j.jad.2017.08.057
NR 32
TC 2
Z9 2
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD DEC
PY 2023
VL 158
AR 106409
DI 10.1016/j.psyneuen.2023.106409
EA OCT 2023
PG 5
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA U7XN6
UT WOS:001086898200001
PM 37801752
DA 2025-06-11
ER

PT J
AU Adachi, N
   Kobayashi, Y
AF Adachi, Naoko
   Kobayashi, Yasuki
TI One-year follow-up study on associations between dental caries,
   periodontitis, and metabolic syndrome
SO JOURNAL OF ORAL SCIENCE
LA English
DT Article
DE dental caries; DMFT; metabolic syndrome; oral health; periodontitis;
   tooth loss
ID ORAL BACTERIA; DISEASE; INFECTION; TEETH; INFLAMMATION; INDUCTION;
   BREAKFAST; STRESS; NUMBER; RISK
AB There have been few prospective studies on the relationship between oral health conditions and the development of metabolic syndrome (MetS). This prospective cohort study was performed at a Japanese company over one year. Routine medical health examinations, oral health examinations, and a questionnaire pertaining to education, job type, and health behaviors was administered. Participants aged >= 35 years who had no MetS components at baseline were re-examined after one year. Modified Poisson regression analyses were performed to calculate the relative risks (RRs) associated with oral health variables, including periodontitis, decayed and missing teeth, and decayed, missing, and filled teeth (DMFT) in relation to the development of MetS. Of 152 eligible participants, 136 were re-examined after one year; 30 exhibited one or more newly developed MetS components upon re-examination. Decayed teeth at baseline were significantly associated with development of at least one MetS component (adjusted RR 3.25, 95% confidence interval 1.59-6.63). There were no associations between periodontitis, missing teeth, or DMFT and the development of MetS. The association between decayed teeth and MetS was independent of other risk factors, including age and body mass index; therefore, decayed teeth may be associated with the development of MetS.
C1 [Adachi, Naoko] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Prevent Oral Hlth Care Sci, Tokyo, Japan.
   [Adachi, Naoko; Kobayashi, Yasuki] Univ Tokyo, Grad Sch Med, Dept Publ Hlth, Tokyo, Japan.
C3 Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU);
   University of Tokyo
RP Adachi, N (corresponding author), Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Prevent Oral Hlth Care Sci, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138510, Japan.
EM adachi.pvoh@tmd.ac.jp
OI Adachi, Naoko/0000-0002-9802-9914; Kobayashi, Yasuki/0000-0002-9616-0687
CR Aarabi G, 2015, ATHEROSCLEROSIS, V241, P555, DOI 10.1016/j.atherosclerosis.2015.04.819
   Aida J, 2006, J EPIDEMIOL, V16, P214, DOI 10.2188/jea.16.214
   AINAMO J, 1982, INT DENT J, V32, P281
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Bergmann N, 2014, ENDOCR CONNECT, V3, pR55, DOI 10.1530/EC-14-0031
   Cao X, 2017, J DIABETES, V9, P378, DOI 10.1111/1753-0407.12424
   Decerle N, 2013, CARIES RES, V47, P330, DOI 10.1159/000348397
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Farshchi HR, 2005, AM J CLIN NUTR, V81, P388
   Fernández-Garcia JC, 2013, CURR VASC PHARMACOL, V11, P906, DOI 10.2174/15701611113116660175
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Gurav Abhijit N, 2014, Dent Res J (Isfahan), V11, P1
   Han YW, 2013, J DENT RES, V92, P485, DOI 10.1177/0022034513487559
   Hayashi C, 2010, MOL ORAL MICROBIOL, V25, P305, DOI 10.1111/j.2041-1014.2010.00582.x
   Kesavalu L, 2012, J DENT RES, V91, P255, DOI 10.1177/0022034511435101
   Kim SW, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000003331
   Kobayashi Y, 2012, J DENT RES, V91, P479, DOI 10.1177/0022034512440707
   Kozarov E, 2006, MICROBES INFECT, V8, P687, DOI 10.1016/j.micinf.2005.09.004
   Laaksonen DE, 2002, AM J EPIDEMIOL, V156, P1070, DOI 10.1093/aje/kwf145
   Lamster IB, 2017, INT DENT J, V67, P67, DOI 10.1111/idj.12264
   LARSSON B, 1992, COMMUNITY DENT ORAL, V20, P133, DOI 10.1111/j.1600-0528.1992.tb01547.x
   Morita T, 2010, J PERIODONTOL, V81, P512, DOI 10.1902/jop.2010.090594
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Nagata E, 2011, MOL ORAL MICROBIOL, V26, P78, DOI 10.1111/j.2041-1014.2010.00597.x
   Nakano K, 2009, ORAL MICROBIOL IMMUN, V24, P64, DOI 10.1111/j.1399-302X.2008.00479.x
   Nibali L, 2013, J CLIN ENDOCR METAB, V98, P913, DOI 10.1210/jc.2012-3552
   Ojima M, 2015, J EPIDEMIOL, V25, P204, DOI 10.2188/jea.JE20140132
   Okubo N, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-562
   Shin HS, 2017, J PERIODONTOL, V88, P830, DOI 10.1902/jop.2017.170089
   Timonen P, 2010, J DENT RES, V89, P1068, DOI 10.1177/0022034510376542
   van der Heijden AAWA, 2007, OBESITY, V15, P2463, DOI 10.1038/oby.2007.292
   Watanabe K, 2014, ARCH ORAL BIOL, V59, P855, DOI 10.1016/j.archoralbio.2014.05.003
   Ylöstalo PV, 2006, J CLIN PERIODONTOL, V33, P92, DOI 10.1111/j.1600-051X.2005.00875.x
   Zhu B, 2015, J EPIDEMIOL, V25, P332, DOI 10.2188/jea.JE20140131
   Zhu Y, 2015, J CLIN PERIODONTOL, V42, P113, DOI 10.1111/jcpe.12361
NR 38
TC 15
Z9 15
U1 1
U2 6
PU NIHON UNIV, SCHOOL DENTISTRY
PI TOYKO
PA 1--13 KANDA-SURUGADAI, CHIYODA-KU, TOYKO, 101-8310, JAPAN
SN 1343-4934
EI 1880-4926
J9 J ORAL SCI
JI J. Oral Sci.
PD JAN
PY 2020
VL 62
IS 1
BP 52
EP 56
DI 10.2334/josnusd.18-0251
PG 5
WC Dentistry, Oral Surgery & Medicine; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine; Materials Science
GA KG5HX
UT WOS:000509980100012
PM 31996523
OA gold
DA 2025-06-11
ER

PT J
AU Rzheshevsky, AV
AF Rzheshevsky, A. V.
TI Decrease in ATP biosynthesis and dysfunction of biological membranes.
   Two possible key mechanisms of phenoptosis
SO BIOCHEMISTRY-MOSCOW
LA English
DT Review
DE fatty acids; leptin; insulin; AMP-activated protein kinase; mTOR;
   oxidative stress; apoptosis; phenoptosis; biomembranes dysfunction;
   mitochondria; endoplasmic reticulum
ID ENDOPLASMIC-RETICULUM STRESS; ACTIVATED PROTEIN-KINASE;
   NECROSIS-FACTOR-ALPHA; FATTY-ACID; METABOLIC SYNDROME; SKELETAL-MUSCLE;
   IKK-BETA; KAPPA-B; LEPTIN; EXPRESSION
AB Metabolic syndrome is extremely prevalent in the world and can be considered as one of main factors leading to accelerated aging and premature death. This syndrome may be closely linked with age-related disruptions in hypothalamic-pituitary system function, which perhaps represent a trigger mechanism of development of endocrine and cardiovascular pathologies. Age-related elevation of the sensitivity threshold of the hypothalamus to regulatory signals in association with low mobility and excessive diet trigger a cascade of biochemical reactions that might be used for activation of programmed death of the organism - phenoptosis. Accumulation of fatty acids in a cell and resulting lipotoxicity include resistance to insulin and leptin, endoplasmic reticulum stress, uncoupling of oxidation and phosphorylation, and dysfunction of biological membranes. Decrease in ATP synthesis is correlated with accumulation of calcium ions in cells, dysfunction of mitochondria, and increasing apoptotic activity. Age-related activation of mTOR (which is greatly influenced by excess energy substrates) has deleterious impact on one of the main mechanisms of cell defense by which defective mitochondria are replaced: mitophagy and biogenesis of mitochondria will be suppressed, and this will increase in greater degree mitochondrial dysfunction and oxidative stress. Fatty acid-induced inflammation will increase activity of nuclear factor NF-kappa B, the well-known stimulator of age-related pathologies. The final stage of phenoptosis can be represented by endothelium dysfunction related with oxidative stress, insulin resistance, and the most prevalent cardiovascular pathologies.
C1 Ctr Rehabil Med, UA-49000 Dnepropetrovsk, Ukraine.
RP Rzheshevsky, AV (corresponding author), Ctr Rehabil Med, Ul Mech 8, UA-49000 Dnepropetrovsk, Ukraine.
EM alex-rjechewsky@mail.ru
CR Alcorta DA, 1996, P NATL ACAD SCI USA, V93, P13742, DOI 10.1073/pnas.93.24.13742
   Aleksandrov A., 2005, CONSILIUM MED, V7, P757
   Anisimov VN, 2008, MOL PHYSL MECH AGING
   Babenko N. A., 2009, NEIROFIZIOLOGIYA, V41, P309
   Banerjee T, 2004, BRIT J HAEMATOL, V124, P391, DOI 10.1046/j.1365-2141.2003.04781.x
   Benoit SC, 2004, RECENT PROG HORM RES, V59, P267, DOI 10.1210/rp.59.1.267
   Bergamini CM, 2004, CURR PHARM DESIGN, V10, P1611, DOI 10.2174/1381612043384664
   Blagosklonny MV, 2013, AGING-US, V5, P490, DOI 10.18632/aging.100580
   Blagosklonny MV, 2009, AGING-US, V1, P357, DOI 10.18632/aging.100040
   Bolli R, 1998, BASIC RES CARDIOL, V93, P156, DOI 10.1007/s003950050079
   BOLLI R, 1990, CIRCULATION, V82, P723, DOI 10.1161/01.CIR.82.3.723
   BROWNLEE M, 1995, ANNU REV MED, V46, P223, DOI 10.1146/annurev.med.46.1.223
   Burnstock G, 2006, TRENDS PHARMACOL SCI, V27, P166, DOI 10.1016/j.tips.2006.01.005
   Burnstock G, 2007, PHYSIOL REV, V87, P659, DOI 10.1152/physrev.00043.2006
   Cai DS, 2012, AGING-US, V4, P98, DOI 10.18632/aging.100431
   Caldwell SH, 1999, J HEPATOL, V31, P430, DOI 10.1016/S0168-8278(99)80033-6
   Canaan A, 2014, P NATL ACAD SCI USA, V111, P5313, DOI 10.1073/pnas.1323426111
   Caro JF, 1996, DIABETES, V45, P1455, DOI 10.2337/diab.45.11.1455
   Castro G, 2013, FEBS OPEN BIO, V3, P443, DOI 10.1016/j.fob.2013.09.002
   Cazanave SC, 2010, CLIN LIPIDOL, V5, P71, DOI 10.2217/CLP.09.85
   Chen CC, 1996, CYTOKINE, V8, P58, DOI 10.1006/cyto.1995.0008
   Chumakov PM, 2007, BIOCHEMISTRY-MOSCOW+, V72, P1399, DOI 10.1134/S0006297907130019
   CORRADIN SB, 1993, EUR J IMMUNOL, V23, P2045, DOI 10.1002/eji.1830230851
   Czaja MJ, 2003, AM J PHYSIOL-GASTR L, V284, pG875, DOI 10.1152/ajpgi.00549.2002
   deGrey ADNJ, 1997, BIOESSAYS, V19, P161, DOI 10.1002/bies.950190211
   Dilman V. M., 1982, BIG BIOL CLOCK
   Dontsov V.I., 2006, T INSTITUTA SISTEMNO, V19, P50
   Drapkina O. M., 2007, ROS MED VESTI, V3, P67
   DULIC V, 1994, CELL, V76, P1013, DOI 10.1016/0092-8674(94)90379-4
   ELDEIRY WS, 1993, CELL, V75, P817, DOI 10.1016/0092-8674(93)90500-P
   Emanuelli B, 2001, J BIOL CHEM, V276, P47944, DOI 10.1074/jbc.M104602200
   Feng ZH, 2007, CANCER RES, V67, P3043, DOI 10.1158/0008-5472.CAN-06-4149
   Fessler MB, 2009, CURR OPIN LIPIDOL, V20, P379, DOI 10.1097/MOL.0b013e32832fa5c4
   Fukuda H, 1999, EUR J BIOCHEM, V260, P505, DOI 10.1046/j.1432-1327.1999.00183.x
   Hannun YA, 2008, NAT REV MOL CELL BIO, V9, P139, DOI 10.1038/nrm2329
   Horton JD, 2002, J CLIN INVEST, V109, P1125, DOI 10.1172/JCI200215593
   Hosoi T, 2008, MOL PHARMACOL, V74, P1610, DOI 10.1124/mol.108.050070
   Illarioshkin S. N., 2012, NERVNYE BOLEZNI, V1, P34
   Inoki K, 2002, NAT CELL BIOL, V4, P648, DOI 10.1038/ncb839
   Johnson ML, 2013, TRENDS ENDOCRIN MET, V24, P247, DOI 10.1016/j.tem.2012.12.003
   Kishkun A. A., 2008, BIOL AGE AGING POSSI
   Klionsky DJ, 2007, NAT REV MOL CELL BIO, V8, P931, DOI 10.1038/nrm2245
   KOTYK A, 1980, MEMBRANE TRANSPORT
   Kowald A, 1999, EXP GERONTOL, V34, P605, DOI 10.1016/S0531-5565(99)00011-X
   Lee CGL, 2003, ONCOGENE, V22, P2592, DOI 10.1038/sj.onc.1206337
   Lee HC, 2012, ADV EXP MED BIOL, V942, P311, DOI 10.1007/978-94-007-2869-1_14
   Lesnefsky EJ, 2004, AM J PHYSIOL-HEART C, V287, pH258, DOI 10.1152/ajpheart.00348.2003
   Levine AJ, 2006, GENE DEV, V20, P267, DOI 10.1101/gad.1363206
   Liao CY, 2011, AGING CELL, V10, P629, DOI 10.1111/j.1474-9726.2011.00702.x
   Loh K, 2011, CELL METAB, V14, P684, DOI 10.1016/j.cmet.2011.09.011
   LUSHNIKOV EF, 2001, CELL DEATH APOPTOSIS
   Malhi H, 2006, J BIOL CHEM, V281, P12093, DOI 10.1074/jbc.M510660200
   Mannaerts GP, 2000, CELL BIOCHEM BIOPHYS, V32, P73, DOI 10.1385/CBB:32:1-3:73
   Marques-Aleixo I, 2012, PROG NEUROBIOL, V99, P149, DOI 10.1016/j.pneurobio.2012.08.002
   MASORO EJ, 1989, J GERONTOL, V44, pB20, DOI 10.1093/geronj/44.1.B20
   Mattson MP, 2008, AGEING RES REV, V7, P43, DOI 10.1016/j.arr.2007.08.004
   Minokoshi Y, 2002, NATURE, V415, P339, DOI 10.1038/415339a
   Minokoshi Y, 2003, BIOCHEM SOC T, V31, P196, DOI 10.1042/bst0310196
   Moraes JC, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005045
   Mounier R, 2011, CELL CYCLE, V10, P2640, DOI 10.4161/cc.10.16.17102
   Novitsky V.V., 2006, B SIB MED, V2, P62
   Obeid Lina M, 2003, Sci Aging Knowledge Environ, V2003, pPE27, DOI 10.1126/sageke.2003.39.pe27
   Ozawa T, 1997, BIOSCIENCE REP, V17, P237, DOI 10.1023/A:1027324410022
   Pamplona R, 2000, MECH AGEING DEV, V112, P169, DOI 10.1016/S0047-6374(99)00045-7
   Patil S, 2007, EUR J NEUROSCI, V26, P2131, DOI 10.1111/j.1460-9568.2007.05797.x
   Patti ME, 2003, P NATL ACAD SCI USA, V100, P8466, DOI 10.1073/pnas.1032913100
   Pérez-Carreras M, 2003, HEPATOLOGY, V38, P999, DOI 10.1053/jhep.2003.50398
   Pes GM, 2004, AGING CLIN EXP RES, V16, P244, DOI 10.1007/BF03327391
   Purkayastha S, 2011, NAT MED, V17, P883, DOI 10.1038/nm.2372
   Qiang W, 2007, EXP MOL MED, V39, P535, DOI 10.1038/emm.2007.59
   Robertson Graham, 2001, American Journal of Physiology, V281, pG1135
   Sanz P, 2008, CURR PROTEIN PEPT SC, V9, P478, DOI 10.2174/138920308785915254
   Schaeffler A, 2009, IMMUNOLOGY, V126, P233, DOI 10.1111/j.1365-2567.2008.02892.x
   Shaw RJ, 2004, P NATL ACAD SCI USA, V101, P3329, DOI 10.1073/pnas.0308061100
   Shulpekova Yu.O, 2012, ROSS ZH GASTROENTERO, V1, P45
   Skulachev V.P, 1998, SOROS OBRAZOVAT ZH, V8, P2
   Skulachev VP, 1997, BIOCHEMISTRY-MOSCOW+, V62, P1191
   Skulachev VP, 1999, BIOCHEMISTRY-MOSCOW+, V64, P1418
   SKULACHEV VP, 2001, SOROS OBRAZOVAT ZH, V7, P4
   SOLMI R, 1994, BIOCHEM MOL BIOL INT, V33, P477
   Sparks LM, 2005, DIABETES, V54, P1926, DOI 10.2337/diabetes.54.7.1926
   Sudakov NP, 2010, ZH NEVROL PSIKHIATR, V110, P87
   Sudakov N.P., 2006, Bull. VSSC SB RAMS., V51, P332
   Sun JZ, 1996, J CLIN INVEST, V97, P562, DOI 10.1172/JCI118449
   [Терешина Е.В. Tereshina H.V.], 2007, [Успехи геронтологии, Uspekhi gerontologii], V20, P59
   Terman A, 2010, ANTIOXID REDOX SIGN, V12, P503, DOI 10.1089/ars.2009.2598
   Titov V N, 2012, Vestn Ross Akad Med Nauk, P65
   Titov V. N, 2011, ROSS KARDIOL ZH, V6, P76
   Titov V. N., 2000, KLIN LAB DIAGN, V4, P3
   Titov V. N., 1999, KLIN LAB DIAGN, V2, P3
   Unger RH, 2005, HYPERTENSION, V45, P1031, DOI 10.1161/01.HYP.0000165683.09053.02
   Unger RH, 2003, ENDOCRINOLOGY, V144, P5159, DOI 10.1210/en.2003-0870
   Urano F, 2000, SCIENCE, V287, P664, DOI 10.1126/science.287.5453.664
   Ushakov A. V., 2005, MEZHDUNAROD MED ZH, V11, P6
   van Exel E, 2002, DIABETES, V51, P1088, DOI 10.2337/diabetes.51.4.1088
   Vasenina E.E., 2013, SOVREM TERAP PSIKHIA, P39
   Vasyuk YA, 2007, RATION PHARMACOTHER, V3, P41
   Viollet B, 2009, ACTA PHYSIOL, V196, P81, DOI 10.1111/j.1748-1716.2009.01970.x
   Vladimiriov A., 2000, SOROS OBRAZOVAT ZH, V6, P2
   Wahid ST, 2001, DIABETES CARE, V24, P2001, DOI 10.2337/diacare.24.11.2001-a
   Wang D, 2006, ENDOCRINOLOGY, V147, P943, DOI 10.1210/en.2005-0570
   Whitmer RA, 2005, BMJ-BRIT MED J, V330, P1360, DOI 10.1136/bmj.38446.466238.E0
   Wood WG, 2002, NEUROBIOL AGING, V23, P685, DOI 10.1016/S0197-4580(02)00018-0
   Xu CY, 2005, J CLIN INVEST, V115, P2656, DOI 10.1172/JCI26373
   Yamaguchi H, 2004, J BIOL CHEM, V279, P45495, DOI 10.1074/jbc.M406933200
   Yamamoto K, 1999, MOL CELL BIOL, V19, P8469
   Zalevskaya A. G., 2008, SAKHARNYI DIABET, V4, P12
   Zhang G, 2013, NATURE, V497, P211, DOI 10.1038/nature12143
NR 108
TC 8
Z9 8
U1 0
U2 9
PU MAIK NAUKA/INTERPERIODICA/SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013-1578 USA
SN 0006-2979
EI 1608-3040
J9 BIOCHEMISTRY-MOSCOW+
JI Biochem.-Moscow
PD OCT
PY 2014
VL 79
IS 10
BP 1056
EP 1068
DI 10.1134/S0006297914100071
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA AR7ID
UT WOS:000343751900007
PM 25519064
DA 2025-06-11
ER

PT J
AU Logvinov, SV
   Mukhomedzyanov, AV
   Kurbatov, BK
   Sirotina, MA
   Naryzhnaya, NV
   Maslov, LN
AF Logvinov, S. V.
   Mukhomedzyanov, A. V.
   Kurbatov, B. K.
   Sirotina, M. A.
   Naryzhnaya, N. V.
   Maslov, L. N.
TI Participation of Leptin and Corticosterone in the Decrease in
   Infarct-Limiting Efficiency of Remote Postconditioning and in the
   Development of Arterial Hypertension in Metabolic Syndrome in Rats
SO BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Article
DE remote postconditioning; metabolic syndrome; myocardium; leptin;
   corticosterone
AB We studied the effect of induced metabolic syndrome (MetS) on the effectiveness of the infarct-limiting effect of remote ischemic postconditioning (RP) in Wistar rats. The involvement of leptin and corticosterone in the formation of arterial hypertension (AH) and in reduction of the effectiveness of RP in MetS was also studied. MetS was induced by high-carbohydrate high-fat diet with replacement of drinking water with 20% fructose solution for 90 days. MetS simulation led to obesity, AH, impaired lipid and carbohydrate metabolism, hyperleptinemia, and moderate stress. All animals were subjected to 45-min coronary occlusion and 120-min reperfusion. In the RP groups, tourniquets were applied on the hind limbs in the area of the hip joint immediately after the end of ischemia (3 cycles consisting of 5-min ischemia and 5-min reperfusion). A direct correlation was found between the severity of AH in rats with MetS and the levels of corticosterone and leptin. In rats with MetS, the effectiveness of RP decreased: a direct correlation between the infarct size and serum content of leptin was revealed in rats with MetS+RP. Corticosterone seems to be one of the factors of AH development in rats with MetS.
C1 [Logvinov, S. V.; Mukhomedzyanov, A. V.; Kurbatov, B. K.; Sirotina, M. A.; Naryzhnaya, N. V.; Maslov, L. N.] Russian Acad Sci, Cardiol Res Inst, Tomsk Natl Res Med Ctr, Tomsk, Russia.
   [Logvinov, S. V.] Siberian State Med Univ, Minist Hlth Russian Federat, Tomsk, Russia.
C3 Russian Academy of Sciences; Tomsk National Research Medical Center;
   Cardiology Research Institute - Tomsk; Ministry of Health of the Russian
   Federation; Siberian State Medical University
RP Naryzhnaya, NV (corresponding author), Russian Acad Sci, Cardiol Res Inst, Tomsk Natl Res Med Ctr, Tomsk, Russia.
EM natalynar@yandex.ru
RI Naryzhnaya, Natalia/F-5310-2017; Maslov, Leonid/Q-7308-2016; Курбатов,
   Борис/AAG-9307-2021; Mukhomedzyanov, Alexander/Q-5752-2016
OI Mukhomedzyanov, Alexander/0000-0003-1808-556X
FU Russian Science Foundation [22-25-20001]; Administration of the Tomsk
   Region
FX The work was supported by the Russian Science Foundation (grant No.
   22-25-20001; https://rscf.ru/project/22-25-20001) and Administration of
   the Tomsk Region. Studies of the mechanisms of AH in induced
   <EM><STRONG> </STRONG></EM>MetS were carried out within the framework of
   the State Assignment No. 122020300042-4. The work was performed using
   the equipment of the Common Use Center "Medical Genomics".
CR Baranyai T, 2015, CARDIOVASC DIABETOL, V14, DOI 10.1186/s12933-015-0313-1
   Gutiérrez-Cuevas J, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10030629
   Landsberg L, 2001, J HYPERTENS, V19, P523, DOI 10.1097/00004872-200103001-00001
   Lochner A, 2020, MOL CELL BIOCHEM, V473, P111, DOI 10.1007/s11010-020-03812-9
   Logvinov SV, 2021, EXP GERONTOL, V154, DOI 10.1016/j.exger.2021.111543
   Mukhomedzyanov AV, 2021, BYULLETEN SIB MED, V20, P6, DOI 10.20538/1682-0363-2021-4-6-10
   Recinella L, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.578966
   Ren J, 2008, OBESITY, V16, P2417, DOI 10.1038/oby.2008.381
   Russell JS, 2019, EXP PHYSIOL, V104, P1868, DOI 10.1113/EP088024
   Schinzari F, 2013, J CLIN ENDOCR METAB, V98, P1235, DOI 10.1210/jc.2012-3424
   Schram K, 2010, CELL MOL BIOL LETT, V15, P551, DOI 10.2478/s11658-010-0027-z
   Van der Mieren G, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-36
   Verouhis D, 2021, CATHETER CARDIO INTE, V97, P386, DOI 10.1002/ccd.28760
   Wen ZY, 2020, OBESITY, V28, P1932, DOI 10.1002/oby.22932
   Xu Tong-tong, 2010, Zhongguo Wei Zhong Bing Ji Jiu Yi Xue, V22, P105
NR 15
TC 2
Z9 2
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0007-4888
EI 1573-8221
J9 B EXP BIOL MED+
JI Bull. Exp. Biol. Med.
PD JAN
PY 2023
VL 174
IS 3
BP 312
EP 317
DI 10.1007/s10517-023-05698-1
EA FEB 2023
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 8O5KT
UT WOS:000925043400019
PM 36723738
DA 2025-06-11
ER

PT J
AU Rajagopalan, P
   Dixit, S
   Alahmari, K
   Devenesan, CS
   Rengaramanujam, K
   Zaman, GS
   Asiri, HA
   Chandramoorthy, HC
AF Rajagopalan, Prasanna
   Dixit, Snehil
   Alahmari, Khalid
   Stephen Devenesan, Charles
   Rengaramanujam, Kanagaraj
   Sarwar Zaman, Gaffar
   Ali Asiri, Hateem
   Chandramoorthy, Harish C.
TI Resistance training influences Adipokines and various biochemical
   factors altering the risk of metabolic syndrome in young male obese
   students
SO MEDICINA DELLO SPORT
LA English
DT Article
DE Adiponectin; Leptin; Metabolic syndrome; Obesity; Resistin; Resistance
   training
ID SALT-SENSITIVE HYPERTENSION; BODY-MASS INDEX; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; SERUM ADIPONECTIN; OXIDATIVE STRESS; LEPTIN
   LEVELS; INFLAMMATION; ADOLESCENTS; CHILDREN
AB BACKGROUND: Young obese adults have a very high risk of developing metabolic syndromes (MetS). I he predisposing factors like adipokines, lipid profile, inflammatory cytokines and antioxidant enzyme status between the sedentary and active life style in young obese individuals have not been elaborately studied. The physiological relationship and impact of resistance trainings over obesity inducing factors in young male obese individuals who are at risk for metabolic syndrome (Mets) were evaluated.
   METHODS: Blood samples were collected before and at different time points of light to moderate and resistance trainings. Adipocytokines, obesity hormones, pro-inflammatory cytokines, lipid profile and antioxidant enzymes were measured using standard spectrophotometric and FLISA methods.
   RESULTS: A proportional increase in adiponectin and HLD-c has been observed post 5th and 10th weeks with respect to control groups. A gradual decrease in lecithin, resistin, SOD, GPx along with TNF alpha and IL-6 were hall mark observations post 5th and 10th week resistance training. There was no significant alternation in obesity inducing factors for non-obese control and light to moderate exercise groups.
   CONCLUSIONS: Resistance training proves beneficial in lowering obesity inducing factors in young obese adults.
C1 [Rajagopalan, Prasanna; Stephen Devenesan, Charles; Sarwar Zaman, Gaffar; Ali Asiri, Hateem] King Khalid Univ, Coll Appl Med Sci, Dept Clin Lab Sci, POB 641, Abha, Saudi Arabia.
   [Dixit, Snehil; Alahmari, Khalid; Rengaramanujam, Kanagaraj] King Khalid Univ, Coll Appl Med Sci, Dept Med Rehabil Sci, Abha, Saudi Arabia.
   [Chandramoorthy, Harish C.] King Khalid Univ, Coll Med, Ctr Stem Cell Res, Abha, Saudi Arabia.
   [Chandramoorthy, Harish C.] King Khalid Univ, Coll Med, Dept Microbiol & Clin Parasitol, Abha, Saudi Arabia.
C3 King Khalid University; King Khalid University; King Khalid University;
   King Khalid University
RP Rajagopalan, P (corresponding author), King Khalid Univ, Coll Appl Med Sci, Dept Clin Lab Sci, POB 641, Abha, Saudi Arabia.
EM rajagopalan@kku.edu.sa
RI Chandramoorthy, Harish/JAC-4762-2023; RENGARAMANUJAM,
   KANAGARAJ/AAT-9174-2020; Dixit, Snehil/H-2757-2019; Alahmari,
   Khalid/AGK-4892-2022; ZAMAN, DR GAFFAR SARWAR/AAQ-8764-2021
OI Rajagopalan, Prasanna/0000-0001-7593-7234; Dixit,
   Snehil/0000-0003-1617-6935; RENGARAMANUJAM,
   KANAGARAJ/0000-0002-0244-7645; ZAMAN, DR GAFFAR
   SARWAR/0000-0002-8740-3990
FU King Khalid University, Abha, Saudi Arabia [G.R.P-97-1438]
FX The research was funded by the Deanship of Scientific Research, King
   Khalid University, Abha, Saudi Arabia (project number G.R.P-97-1438).
CR Adeghate E, 2004, CELL MOL LIFE SCI, V113, P1234
   AEBI H, 1984, METHOD ENZYMOL, V105, P121
   Ahima RS, 2000, ANNU REV PHYSIOL, V62, P413, DOI 10.1146/annurev.physiol.62.1.413
   Akbarpour M, 2013, BIOL SPORT, V30, P21, DOI 10.5604/20831862.1029817
   Cardoso GA, 2016, MED SPORT, V69, P13
   Carmela RB, 2010, MEDIAT INFLAMM
   Caterson ID, 2004, CIRCULATION, V110, pE476, DOI 10.1161/01.CIR.0000140114.83145.59
   Cook S, 2003, ARCH PEDIAT ADOL MED, V157, P821, DOI 10.1001/archpedi.157.8.821
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Fernández-Real JM, 2003, J CLIN ENDOCR METAB, V88, P2714, DOI 10.1210/jc.2002-021583
   Fujita T, 2008, J MOL MED, V86, P729, DOI 10.1007/s00109-008-0343-1
   Fujita T, 2007, NEPHROL DIAL TRANSPL, V22, P3102, DOI 10.1093/ndt/gfm409
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Galedari M., 2014, European Journal of Zoological Research, V3, P86
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Izadi V, 2013, INT J PREVENTIVE MED, V4, P133
   John Z, 2015, ENDOCRINOL METAB SYN, V4, P1
   Jolliffe CJ, 2007, J AM COLL CARDIOL, V49, P891, DOI 10.1016/j.jacc.2006.08.065
   Kang YE, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0154003
   Kudo N, 1996, BBA-LIPID LIPID MET, V1301, P67, DOI 10.1016/0005-2760(96)00013-6
   Lafontan M, 2006, CURR OPIN PHARMACOL, V6, P580, DOI 10.1016/j.coph.2006.08.002
   Lago F, 2007, CYTOKINE GROWTH F R, V18, P313, DOI 10.1016/j.cytogfr.2007.04.007
   MARKLUND S, 1974, EUR J BIOCHEM, V47, P469
   Matsuura F, 2007, BIOCHEM BIOPH RES CO, V358, P1091, DOI 10.1016/j.bbrc.2007.05.040
   Mei ZG, 2002, AM J CLIN NUTR, V75, P978, DOI 10.1093/ajcn/75.6.978
   MOHLER H, 1988, EUR J ANAESTH, P15
   Nindl BC, 2002, MED SCI SPORT EXER, V34, P608, DOI 10.1097/00005768-200204000-00008
   Ogden CL, 2012, JAMA-J AM MED ASSOC, V307, P483, DOI [10.1001/jama.2012.39, 10.1001/jama.2012.40]
   PAGLIA DE, 1967, J LAB CLIN MED, V70, P158
   Pearson TA, 2003, CIRCULATION, V107, P499, DOI 10.1161/01.CIR.0000052939.59093.45
   Plourde Gilles, 2002, BMC Fam Pract, V3, P18, DOI 10.1186/1471-2296-3-18
   Qiuping Z, 2017, MED SPORT, V70, P503
   Ridker PM, 2004, CIRCULATION, V109, P2818, DOI 10.1161/01.CIR.0000132467.45278.59
   Rizzo ACB, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-19
   Roberts CK, 2013, COMPR PHYSIOL, V3, P1, DOI 10.1002/cphy.c110062
   Rojo AI, 2014, ANTIOXID REDOX SIGN, V21, P1766, DOI 10.1089/ars.2013.5745
   Saeid G, EXERCISE INDUCED ADI
   Shu-Ju C, 2012, PLOS ONE, V7, P1
   Silha JV, 2003, EUR J ENDOCRINOL, V149, P331, DOI 10.1530/eje.0.1490331
   Szmitko PE, 2003, CIRCULATION, V108, P1917, DOI 10.1161/01.CIR.0000089190.95415.9F
   West IC, 2000, DIABETIC MED, V17, P171, DOI 10.1046/j.1464-5491.2000.00259.x
   Weyer C, 2001, J CLIN ENDOCR METAB, V86, P1930, DOI 10.1210/jc.86.5.1930
   Wulster-Radcliffe MC, 2012, BIOCHEM BIOPH RES CO, V316, P924
   Yamaguchi N, 2005, FEBS LETT, V579, P6821, DOI 10.1016/j.febslet.2005.11.019
   Yoon MJ, 2006, DIABETES, V55, P2562, DOI 10.2337/db05-1322
   Zhang Jianliang, 2002, Zhonghua Yi Xue Za Zhi, V82, P1609
   Zimmet P, 2007, PEDIATR DIABETES, V8, P299, DOI 10.1111/j.1399-5448.2007.00271.x
   Zimmet P, 2005, J ATHEROSCLER THROMB, V12, P295, DOI 10.5551/jat.12.295
NR 50
TC 2
Z9 2
U1 1
U2 8
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0025-7826
EI 1827-1863
J9 MED SPORT
JI Med. Sport
PD DEC
PY 2018
VL 71
IS 4
BP 561
EP +
DI 10.23736/S0025-7826.18.03431-2
PG 19
WC Medicine, General & Internal; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Sport Sciences
GA HI5GY
UT WOS:000456481700007
DA 2025-06-11
ER

PT J
AU Oliva, MM
   Minutolo, E
   Lippa, A
   Iaconianni, P
   Vaiarelli, A
AF Oliva, Mario Montanino
   Minutolo, Elisa
   Lippa, Assunta
   Iaconianni, Paola
   Vaiarelli, Alberto
TI Effect of Myoinositol and Antioxidants on Sperm Quality in Men with
   Metabolic Syndrome
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID INOSITOL TRISPHOSPHATE; MITOCHONDRIAL-FUNCTION; INSULIN-RESISTANCE; MALE
   REPRODUCTION; OXIDATIVE STRESS; OBESITY; ARGININE; SPERMATOZOA;
   VITALITY; SELENIUM
AB This prospective longitudinal study investigated the effects of a dietary supplement in patients affected by reduced sperm motility (asthenospermic males) with metabolic syndrome. The product tested was Andrositol (R), which contains myoinositol (MI) as principal compound, in association with other molecules, and the parameters evaluated were semen characteristics as well as hormone and metabolic profiles. The inclusion criteria were subjects aged over 18 years, with asthenospermia and metabolic syndrome. The exclusion criteria were presence of cryptorchidism, varicocele, and prostatitis. For this study, 45 males who had such features were enrolled. Their selection was made according to the 2010 World Health Organization (WHO) criteria (5th Edition) for the Evaluation of Human Semen. Hormone and metabolic profiles and semen parameters were assessed at the beginning of the study and after three months of treatment with Andrositol. The differences between the values before and after the supplementation were found statistically significant. Andrositol normalized the metabolic profile of these patients, improving their insulin sensitivity. Moreover, testosterone levels were increased and the semen characteristics, such as sperm concentration, motility, and morphology, highly improved. In conclusion, the association of MI with other molecules (micronutrients and vitamins) could be an effective therapy for metabolic disorders, as well as hormonal and spermatic changes responsible for male infertility.
C1 [Oliva, Mario Montanino] Santo Spirito Hosp, Dept Obstet & Gynecol, I-00193 Rome, Italy.
   [Oliva, Mario Montanino; Minutolo, Elisa; Lippa, Assunta; Iaconianni, Paola] Altamed IVF Unit, I-00198 Rome, Italy.
   [Vaiarelli, Alberto] Univ Hosp, Reprod Med Unit, I-98122 Messina, Italy.
C3 AOU Policlinico Gaetano Martino
RP Oliva, MM (corresponding author), Santo Spirito Hosp, Dept Obstet & Gynecol, I-00193 Rome, Italy.; Oliva, MM (corresponding author), Altamed IVF Unit, I-00198 Rome, Italy.
EM mario.montanino@virgilio.it
RI Oliva, Mario/AAG-9711-2019
CR Agarwal A, 2004, REPROD BIOMED ONLINE, V8, P616, DOI 10.1016/S1472-6483(10)61641-0
   Agarwal A, 2003, FERTIL STERIL, V79, P829, DOI 10.1016/S0015-0282(02)04948-8
   Ahsan U, 2014, ANIM REPROD SCI, V146, P55, DOI 10.1016/j.anireprosci.2014.01.009
   Aitken RJ, 2010, HUM REPROD, V25, P2415, DOI 10.1093/humrep/deq214
   AITKEN RJ, 1989, BIOL REPROD, V41, P183, DOI 10.1095/biolreprod41.1.183
   Aydin S., 1995, International Urology and Nephrology, V27, P199, DOI 10.1007/BF02551320
   Bahat A, 2010, BIOL REPROD, V82, P606, DOI 10.1095/biolreprod.109.080127
   Basaria S, 2008, J ANDROL, V29, P534, DOI 10.2164/jandrol.108.005454
   BAUCHE F, 1994, FEBS LETT, V349, P392, DOI 10.1016/0014-5793(94)00709-8
   BERRIDGE MJ, 1993, NATURE, V361, P315, DOI 10.1038/361315a0
   Bizzarri M, 2014, EUR REV MED PHARMACO, V18, P1896
   Boni R, 2007, THERIOGENOLOGY, V68, pS156, DOI 10.1016/j.theriogenology.2007.05.048
   Bray George A., 1997, Human Reproduction (Oxford), V12, P26
   Caldas ADA, 2009, ARQ BRAS ENDOCRINOL, V53, P1005, DOI 10.1590/S0004-27302009000800015
   Carlomagno G, 2011, EUR J OBSTET GYN R B, V159, P267, DOI 10.1016/j.ejogrb.2011.07.038
   Carvalheira José B.C., 2006, Arq Bras Endocrinol Metab, V50, P360, DOI 10.1590/S0004-27302006000200022
   Cavallini G, 2006, ASIAN J ANDROL, V8, P143, DOI 10.1111/j.1745-7262.2006.00123.x
   Colone M, 2010, EUR REV MED PHARMACO, V14, P891
   Condorelli RA, 2011, EUR REV MED PHARMACO, V15, P129
   Condorelli RA, 2012, UROLOGY, V79, P1290, DOI 10.1016/j.urology.2012.03.005
   Cooper TG, 2010, HUM REPROD UPDATE, V16, P559, DOI [10.1093/humupd/dmp048, 10.1093/humupd/dmq020]
   Desai N, 2009, FERTIL STERIL, V92, P1626, DOI 10.1016/j.fertnstert.2008.08.109
   DIVECHA N, 1995, CELL, V80, P269, DOI 10.1016/0092-8674(95)90409-3
   Foresta C, 2002, BIOL REPROD, V67, P967, DOI 10.1095/biolreprod.102.003822
   Foresta C, 2009, CLIN ENDOCRINOL, V71, P722, DOI 10.1111/j.1365-2265.2009.03549.x
   Genazzani AD, 2008, GYNECOL ENDOCRINOL, V24, P139, DOI 10.1080/09513590801893232
   Giordano D, 2011, MENOPAUSE, V18, P102, DOI 10.1097/gme.0b013e3181e8e1b1
   Goulis DG, 2008, GYNECOL ENDOCRINOL, V24, P33, DOI 10.1080/09513590701582273
   Govil G., 1992, LIPID SOLUBLE ANTIOX, P27
   Holt L.E., 1944, T ARCH ASS AM PHYS, V58, P143
   Isidori AM, 1999, J CLIN ENDOCR METAB, V84, P3673, DOI 10.1210/jc.84.10.3673
   Jungwirth A, 2012, EUR UROL, V62, P324, DOI 10.1016/j.eururo.2012.04.048
   Kao SH, 2008, FERTIL STERIL, V89, P1183, DOI 10.1016/j.fertnstert.2007.05.029
   Kumalic SI, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/426951
   Laaksonen DE, 2004, DIABETES CARE, V27, P1036, DOI 10.2337/diacare.27.5.1036
   Li JL, 2011, BIOMETALS, V24, P291, DOI 10.1007/s10534-010-9395-0
   Liu PY, 2003, HUM REPROD UPDATE, V9, P9, DOI 10.1093/humupd/dmg002
   Livingstone C, 2002, CLIN SCI, V102, P151, DOI 10.1042/cs1020151
   Lordelo RA, 2007, ARQ BRAS ENDOCRINOL, V51, P34, DOI 10.1590/S0004-27302007000100007
   Magni P, 2000, REGUL PEPTIDES, V92, P51, DOI 10.1016/S0167-0115(00)00149-X
   Matos Amélio F. Godoy, 2003, Arq Bras Endocrinol Metab, V47, P410, DOI 10.1590/S0004-27302003000400013
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Michalakis K, 2013, METABOLISM, V62, P457, DOI 10.1016/j.metabol.2012.08.012
   MROUEH A, 1970, FERTIL STERIL, V21, P217
   Muller M, 2005, J CLIN ENDOCR METAB, V90, P2618, DOI 10.1210/jc.2004-1158
   Nestler JE, 1999, NEW ENGL J MED, V340, P1314, DOI 10.1056/NEJM199904293401703
   Patel AB, 1998, BIOPHYS J, V75, P1522, DOI 10.1016/S0006-3495(98)74071-8
   Pavlovich CP, 2001, J UROLOGY, V165, P837, DOI 10.1016/S0022-5347(05)66540-8
   RADANY EW, 1981, ARCH BIOCHEM BIOPHYS, V210, P770, DOI 10.1016/0003-9861(81)90244-7
   Rivlin J, 2004, BIOL REPROD, V70, P518, DOI 10.1095/biolreprod.103.020487
   Robeva R, 2008, Akush Ginekol (Sofiia), V47, P11
   Santamaria A, 2012, CLIMACTERIC, V15, P490, DOI 10.3109/13697137.2011.631063
   Scibona M, 1994, Minerva Urol Nefrol, V46, P251
   Shalini S, 2005, BIOFACTORS, V23, P151, DOI 10.1002/biof.5520230304
   Showell MG, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007411.pub3
   Srivastava S, 2006, BIOL REPROD, V74, P954, DOI 10.1095/biolreprod.105.046896
   Srivastava Sudha, 2000, Physiological Chemistry and Physics and Medical NMR, V32, P127
   Teerds KJ, 2011, HUM REPROD UPDATE, V17, P667, DOI 10.1093/humupd/dmr017
   Unfer V, 2012, GYNECOL ENDOCRINOL, V28, P509, DOI 10.3109/09513590.2011.650660
   Yeung CH, 2004, J ANDROL, V25, P216
   Zini A, 2009, J ASSIST REPROD GEN, V26, P427, DOI 10.1007/s10815-009-9343-5
NR 61
TC 19
Z9 19
U1 0
U2 0
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2016
VL 2016
AR 1674950
DI 10.1155/2016/1674950
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DY4TC
UT WOS:000385091300001
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Palomo, I
   Contreras, A
   Alarcón, LM
   Leiva, E
   Guzmán, L
   Mujica, V
   Icaza, G
   Díaz, N
   González, DR
   Moore-Carrasco, R
AF Palomo, Ivan
   Contreras, Alejandra
   Marcelo Alarcon, L.
   Leiva, Elba
   Guzman, Luis
   Mujica, Veronica
   Icaza, Gloria
   Diaz, Nora
   Gonzalez, Daniel R.
   Moore-Carrasco, Rodrigo
TI Elevated concentration of asymmetric dimethylarginine (ADMA) in
   individuals with metabolic syndrome
SO NITRIC OXIDE-BIOLOGY AND CHEMISTRY
LA English
DT Article
DE Metabolic syndrome; Endothelial dysfunction; Nitric oxide inhibitor;
   Asymmetric dimethyl arginine; Oxidative stress; Insulin resistance
ID NITRIC-OXIDE SYNTHASE; INSULIN-RESISTANCE; POTENTIAL LINK; PLASMA;
   DISEASE; OBESITY; RISK; ADHESIVENESS; CHOLESTEROL; DYSFUNCTION
AB The metabolic syndrome (MS) is a cluster of pathophysiological alterations that includes the presence of hypertension, insulin resistance, dyslipidemia, and abdominal obesity. MS is associated with increased risk of developing diabetes and cardiovascular diseases. Endothelial dysfunction with impaired nitric oxide (NO) bioavailability has been implicated in insulin resistance and hypertension. NO is synthesized by nitric oxide synthase (NOS) using L-arginine as substrate. Asymmetric dimethyl arginine (ADMA) is a major and potent endogenous NOS inhibitor, associated with cardiovascular and renal diseases. We tested the hypothesis that plasmatic ADMA levels are increased in patients with MS.
   We studied 85 adult individuals from Talca, Chile, separated in two groups, 48 individuals with MS (according to modified ATP III criteria), and 37 individuals without MS as controls. ADMA levels were significantly increased in the MS group (mean +/- standard deviation 0.71 +/- 0.38 vs. 0.48 +/- 0.28 mu mol/L, p = 0.0009). Furthermore, the levels of ADMA were modestly but significantly correlated with waist circumference (p = 0.01) but not with the other components of MS (blood pressure, glycemia, triglycerides and high density lipoprotein cholesterol HDL-c). These results suggest a possible link between increased ADMA levels and the MS. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Palomo, Ivan; Contreras, Alejandra; Marcelo Alarcon, L.; Leiva, Elba; Guzman, Luis; Moore-Carrasco, Rodrigo] Univ Talca, Fac Ciencias Salud, Dept Bioquim Clin & Inmunohematol, Talca, Chile.
   [Mujica, Veronica] Univ Talca, Escuela Med, Talca, Chile.
   [Icaza, Gloria; Diaz, Nora] Univ Talca, Inst Matemat & Fis, Talca, Chile.
   [Gonzalez, Daniel R.] Univ Talca, Fac Ciencias Salud, Dept Ciencias Basicas Biomed, Talca, Chile.
C3 Universidad de Talca; Universidad de Talca; Universidad de Talca;
   Universidad de Talca
RP Palomo, I (corresponding author), Univ Talca, Fac Ciencias Salud, Dept Bioquim Clin & Inmunohematol, POB 747, Talca, Chile.
EM ipalomo@utalca.cl
RI Palomo, Iván/I-4321-2018; Moore-Carrasco, Rodrigo/AAK-3349-2020;
   Alarcon, Marcelo/I-5016-2018; Contreras, Alejandra/E-7815-2013; Guzmán,
   Luis/HLH-3515-2023
OI Palomo, Ivan/0000-0002-9618-8778; Icaza, Gloria/0000-0002-3192-3428;
   Mujica, Veronica/0000-0001-6290-410X; Guzman, Luis/0000-0003-1552-7430;
   GONZALEZ, DANIEL/0000-0002-3437-8998; alarcon,
   marcelo/0000-0001-7596-5382; Moore-Carrasco, Rodrigo/0000-0003-4870-9660
FU Cardiovascular Disease Risk Factors (PIFRECV), Universidad de Talca,
   Talca, Chile
FX Supported by the Research Program of Cardiovascular Disease Risk Factors
   (PIFRECV), Universidad de Talca, Talca, Chile.
CR Achan V, 2003, ARTERIOSCL THROM VAS, V23, P1455, DOI 10.1161/01.ATV.0000081742.92006.59
   Böger RH, 2009, CIRCULATION, V119, P1592, DOI 10.1161/CIRCULATIONAHA.108.838268
   Böger RH, 2000, J AM COLL CARDIOL, V36, P2287, DOI 10.1016/S0735-1097(00)01013-5
   Böger RH, 2000, CIRC RES, V87, P99, DOI 10.1161/01.RES.87.2.99
   Böger RH, 2003, CARDIOVASC RES, V59, P824, DOI 10.1016/S0008-6363(03)00500-5
   Chan JR, 2000, ARTERIOSCL THROM VAS, V20, P1040, DOI 10.1161/01.ATV.20.4.1040
   Chan NN, 2002, DIABETOLOGIA, V45, P1609, DOI 10.1007/s00125-002-0975-6
   Chirinos JA, 2008, HYPERTENSION, V52, P1051, DOI 10.1161/HYPERTENSIONAHA.108.120352
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Eid HMA, 2004, METABOLISM, V53, P1574, DOI 10.1016/j.metabol.2004.06.026
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Gomes VA, 2008, NITRIC OXIDE-BIOL CH, V19, P345, DOI 10.1016/j.niox.2008.08.005
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Kielstein JT, 2004, CIRCULATION, V109, P172, DOI 10.1161/01.CIR.0000105764.22626.B1
   Krzyzanowska K, 2004, J CLIN ENDOCR METAB, V89, P6277, DOI 10.1210/jc.2004-0672
   Leiper J, 2007, NAT MED, V13, P198, DOI 10.1038/nm1543
   Leong T, 2008, ARTERIOSCL THROM VAS, V28, P961, DOI 10.1161/ATVBAHA.107.156596
   Maas R, 2007, CLIN CHEM, V53, P693, DOI 10.1373/clinchem.2006.081893
   Marliss EB, 2006, DIABETOLOGIA, V49, P351, DOI 10.1007/s00125-005-0066-6
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McLaughlin T, 2006, J CLIN ENDOCR METAB, V91, P1896, DOI 10.1210/jc.2005-1441
   Monsalve E, 2007, CARDIOVASC RES, V73, P66, DOI 10.1016/j.cardiores.2006.09.020
   Mujica V, 2008, NUTR J, V7, DOI 10.1186/1475-2891-7-14
   Napoli C, 2006, NITRIC OXIDE-BIOL CH, V15, P265, DOI 10.1016/j.niox.2006.03.011
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   PALOMO I, 2010, CLIN RES REV, V4, P234
   Palomo I, 2007, REV MED CHILE, V135, P904
   Palomo IG, 2009, MOL MED REP, V2, P481, DOI 10.3892/mmr_00000125
   Schulman I, 2009, CURR HYPERTENS REP, V11, P48, DOI 10.1007/s11906-009-0010-0
   Shaw JE, 2006, DIABETES CARE, V29, P1170, DOI 10.2337/dc06-0013
   Spoto B, 2007, J NEPHROL, V20, P554
   Tziomalos K, 2010, NUTR METAB CARDIOVAS, V20, P140, DOI 10.1016/j.numecd.2009.08.006
   Valkonen VP, 2001, LANCET, V358, P2127, DOI 10.1016/S0140-6736(01)07184-7
   Vallance P, 2004, ARTERIOSCL THROM VAS, V24, P1023, DOI 10.1161/01.ATV.0000128897.54893.26
   Wang D, 2009, AM J PHYSIOL-REG I, V296, pR195, DOI 10.1152/ajpregu.90506.2008
NR 35
TC 52
Z9 53
U1 0
U2 6
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1089-8603
EI 1089-8611
J9 NITRIC OXIDE-BIOL CH
JI Nitric Oxide-Biol. Chem.
PD MAY 31
PY 2011
VL 24
IS 4
BP 224
EP 228
DI 10.1016/j.niox.2011.03.002
PG 5
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 775KE
UT WOS:000291457400009
PM 21419857
DA 2025-06-11
ER

PT J
AU Klisic, A
   Kotur-Stevuljevic, J
   Patoulias, D
   Ninic, A
AF Klisic, Aleksandra
   Kotur-Stevuljevic, Jelena
   Patoulias, Dimitrios
   Ninic, Ana
TI Serum Endocan Levels in Postmenopausal Women with Metabolic Syndrome
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE endothelial dysfunction; inflammation; insulin resistance; oxidative
   stress
ID ASSOCIATION; PRODUCTS
AB Aim: Studies that explored endocan (as a novel marker of endothelial dysfunction) in relation to metabolic syndrome (MetS) are scarce and show discordant results. Importantly, no study has yet examined serum endocan levels in exclusively postmenopausal women with MetS and free of diabetes. Oxidative stress and inflammation are the key features of MetS and consequently cardiovascular diseases. Hence, we aimed to explore the potential relationship between endocan, oxidative stress [i.e., determined by total antioxidant status, total oxidant status, and pro-oxidant/antioxidant balance (PAB)], inflammation, and MetS in a cohort of postmenopausal women.Methods: A total of 126 postmenopausal women were included consecutively. MetS was diagnosed following the International Diabetes Federation criteria.Results: Higher serum endocan levels were found in MetS group as compared with MetS-free counterparts [6.03 (3.47-10.37) pg/mL vs. 2.27 (1.49-3.50) pg/mL, P < 0.001]. Endocan showed good discriminatory ability toward MetS [area under the curve (AUC) = 0.809]. Besides age, the inclusion of oxidative stress and inflammation biomarkers, such as PAB and high-sensitivity C-reactive protein (hsCRP), the AUC for discrimination postmenopausal women with MetS from MetS-free women was 0.845.Conclusion: Postmenopausal women with MetS exhibited almost 2.7 times higher serum endocan level as compared with MetS-free middle-aged women. Endocan showed good discriminatory ability toward MetS and could be a diagnostic marker in MetS. Similar results were confirmed when added an age, oxidative stress, and inflammation biomarkers (i.e., PAB and hsCRP) were included for the discrimination of postmenopausal with MetS from MetS-free women.
C1 [Klisic, Aleksandra] Univ Montenegro, Fac Med, Podgorica, Montenegro.
   [Klisic, Aleksandra] Primary Hlth Care Ctr, Ctr Lab Diagnost, Podgorica, Montenegro.
   [Kotur-Stevuljevic, Jelena; Ninic, Ana] Univ Belgrade, Fac Pharm, Dept Med Biochem, Belgrade, Serbia.
   [Patoulias, Dimitrios] Aristotle Univ Thessaloniki, Gen Hosp Hippokration, Outpatient Dept Cardiometab Med, Dept Cardiol 2, Thessaloniki, Greece.
   [Klisic, Aleksandra] Univ Montenegro, Fac Med, Ctr Lab Diagnost, Primary Hlth Care Ctr, Trg Nikole Kovacev 6, Podgorica 81000, Montenegro.
C3 University of Montenegro; University of Belgrade; Aristotle University
   of Thessaloniki; University of Montenegro
RP Klisic, A (corresponding author), Univ Montenegro, Fac Med, Ctr Lab Diagnost, Primary Hlth Care Ctr, Trg Nikole Kovacev 6, Podgorica 81000, Montenegro.
EM aleksandranklisic@gmail.com
RI Patoulias, Dimitrios/AAH-8861-2019; Klisic, Aleksandra/ABC-9219-2020
OI Ninic, Ana/0000-0003-3838-1606
FU Ministry of Science and Technological Development, Montenegro; Ministry
   of Education, Science and Technological Development, Republic of Serbia
   [451-03-68/2020-14/200161]
FX This work was financially supported in part by a grant from the Ministry
   of Science and Technological Development, Montenegro and the Ministry of
   Education, Science and Technological Development, Republic of Serbia
   (project number 451-03-68/2020-14/200161).
CR Alamdari DH, 2007, CLIN BIOCHEM, V40, P248, DOI 10.1016/j.clinbiochem.2006.10.017
   [Anonymous], 2005, The IDF consensus worldwide definition of the metabolic syndrome
   Arman Y, 2022, ARQ BRAS CARDIOL, V119, P544, DOI 10.36660/abc.20210797
   Bicer M, 2017, ENDOCR RES, V42, P145, DOI 10.1080/07435800.2016.1255896
   Boyuk Banu, 2020, Arch Med Sci Atheroscler Dis, V5, pe290, DOI 10.5114/amsad.2020.103031
   Chen JZ, 2022, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.798699
   Cyunczyk M, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11020283
   Dallio M, 2017, J GASTROINTEST LIVER, V26, P261, DOI 10.15403/jgld.2014.1121.263.dal
   Ehteram H, 2023, ENDOCRIN DIAB METAB, V6, DOI 10.1002/edm2.400
   Erel O, 2004, CLIN BIOCHEM, V37, P277, DOI 10.1016/j.clinbiochem.2003.11.015
   Erel O, 2005, CLIN BIOCHEM, V38, P1103, DOI 10.1016/j.clinbiochem.2005.08.008
   Ghazizadeh H., 2020, Obes Med, V19, P100272, DOI [10.1016/j.obmed.2020.100272, DOI 10.1016/J.OBMED.2020.100272]
   Halici I, 2016, PEDIATR INT, V58, P1124, DOI 10.1111/ped.12989
   Iwanczyk S, 2022, POL ARCH INTERN MED, V132, DOI 10.20452/pamw.16292
   Jeong HG, 2022, METABOLITES, V12, DOI 10.3390/metabo12100954
   Khalaji A, 2023, DIABETOL METAB SYNDR, V15, DOI 10.1186/s13098-023-01076-z
   Klisic A, 2020, EUR REV MED PHARMACO, V24, P8127, DOI 10.26355/eurrev_202008_22499
   Klisic A, 2020, EUR REV MED PHARMACO, V24, P7131, DOI 10.26355/eurrev_202006_21707
   Klisic A, 2023, METABOLITES, V13, DOI 10.3390/metabo13050640
   Klisic A, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-97686-6
   Klisic A, 2020, ARCH MED SCI, V16, P42, DOI 10.5114/aoms.2019.87541
   Klisic A, 2019, J MED BIOCHEM, V38, P361, DOI 10.2478/jomb-2018-0035
   Klisic A, 2018, EAT WEIGHT DISORD-ST, V23, P133, DOI 10.1007/s40519-016-0325-1
   Klisic A, 2017, ARCH MED SCI, V13, P1188, DOI 10.5114/aoms.2017.68972
   Leanza G, 2023, CELLS-BASEL, V12, DOI 10.3390/cells12081137
   Gutiérrez-Solis AL, 2023, METAB SYNDR RELAT D, V21, P188, DOI 10.1089/met.2023.0001
   Montoya-Estrada A, 2022, J OBSTET GYNAECOL, V42, P2387, DOI 10.1080/01443615.2022.2062223
   NAGELKERKE NJD, 1991, BIOMETRIKA, V78, P691, DOI 10.1093/biomet/78.3.691
   Nalbantoglu A, 2021, ANGIOLOGY, V72, P633, DOI 10.1177/0003319721995664
   Blagojevic IMP, 2022, BRIT J NUTR, V128, P604, DOI 10.1017/S0007114521003585
   Vassalle C, 2022, FRONT CARDIOVASC MED, V9, DOI 10.3389/fcvm.2022.875551
NR 31
TC 2
Z9 2
U1 1
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD DEC 1
PY 2023
VL 21
IS 10
BP 561
EP 566
DI 10.1089/met.2023.0119
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CB9K8
UT WOS:001122906700003
PM 37669459
DA 2025-06-11
ER

PT J
AU Chen, SJ
   Yen, CH
   Huang, YC
   Lee, BJ
   Hsia, S
   Lin, PT
AF Chen, Shu-Ju
   Yen, Chi-Hua
   Huang, Yi-Chia
   Lee, Bor-Jen
   Hsia, Simon
   Lin, Ping-Ting
TI Relationships between Inflammation, Adiponectin, and Oxidative Stress in
   Metabolic Syndrome
SO PLOS ONE
LA English
DT Article
ID C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; DIABETES-MELLITUS;
   INTERLEUKIN-6; OBESITY; PREVALENCE; HYPERTENSION; ASSOCIATION;
   POPULATION; MARKERS
AB Metabolic syndrome (MS) represents a cluster of physiological and anthropometric abnormalities. The purpose of this study was to investigate the relationships between the levels of inflammation, adiponectin, and oxidative stress in subjects with MS. The inclusion criteria for MS, according to the Taiwan Bureau of Health Promotion, Department of Health, were applied to the case group (n = 72). The control group (n = 105) comprised healthy individuals with normal blood biochemical values. The levels of inflammatory markers [high sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6), adiponectin, an oxidative stress marker (malondialdehyde), and antioxidant enzymes activities [catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)] were measured. Subjects with MS had significantly higher concentrations of inflammatory markers and lower adiponectin level, and lower antioxidant enzymes activities than the control subjects. The levels of inflammatory markers and adiponectin were significantly correlated with the components of MS. The level of hs-CRP was significantly correlated with the oxidative stress marker. The IL-6 level was significantly correlated with the SOD and GPx activities, and the adiponectin level was significantly correlated with the GPx activity. A higher level of hs-CRP (>= 1.00 mg/L), or IL-6 (>= 1.50 pg/mL) or a lower level of adiponectin (<7.90 mu g/mL) were associated with a significantly greater risk of MS. In conclusion, subjects suffering from MS may have a higher inflammation status and a higher level of oxidative stress. A higher inflammation status was significantly correlated with decreases in the levels of antioxidant enzymes and adiponectin and an increase in the risk of MS.
C1 [Huang, Yi-Chia; Lee, Bor-Jen; Lin, Ping-Ting] Chung Shan Med Univ, Sch Nutr, Taichung, Taiwan.
   [Chen, Shu-Ju] Chung Chou Univ Sci & Technol, Dept Hlth Food, Changhua, Taiwan.
   [Yen, Chi-Hua] Chung Shan Med Univ Hosp, Dept Family & Community Med, Taichung, Taiwan.
   [Yen, Chi-Hua] Chung Shan Med Univ, Sch Med, Taichung, Taiwan.
   [Yen, Chi-Hua] Chung Shan Med Univ, Ctr Educ & Res Geriatr & Gerontol, Taichung, Taiwan.
   [Huang, Yi-Chia; Lin, Ping-Ting] Chung Shan Med Univ Hosp, Dept Nutr, Taichung, Taiwan.
   [Lee, Bor-Jen] Taichung Vet Gen Hosp, Intens Care Unit, Taichung, Taiwan.
   [Hsia, Simon] HungKuang Univ, Dept Nutr, Taichung, Taiwan.
   [Hsia, Simon] HungKuang Univ, Inst Biomed Nutr, Taichung, Taiwan.
C3 Chung Shan Medical University; Chung Shan Medical University; Chung Shan
   Medical University Hospital; Chung Shan Medical University; Chung Shan
   Medical University; Chung Shan Medical University; Chung Shan Medical
   University Hospital; Taichung Veterans General Hospital; Hungkuang
   University; Hungkuang University
RP Lin, PT (corresponding author), Chung Shan Med Univ, Sch Nutr, Taichung, Taiwan.
EM apt810@csmu.edu.tw
RI Huang, Yi-Chia/AAS-8877-2021; Stefanadis, Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454; Huang,
   Yi-Chia/0000-0003-2234-4464
FU National Science Council of Taiwan [NSC 99-2320-B-040-011]
FX This study was supported by a grant from the National Science Council
   (NSC 99-2320-B-040-011) of Taiwan. The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
CR Aebi H, 1984, Methods Enzymol, V105, P121
   Antoniades C, 2003, HERZ, V28, P628, DOI 10.1007/s00059-003-2417-8
   BATAILLE R, 1992, ARTHRITIS RHEUM-US, V35, P982, DOI 10.1002/art.1780350824
   CERIELLO A, 1993, DIABETOLOGIA, V36, P265, DOI 10.1007/BF00399961
   Choi KM, 2007, DIABETES RES CLIN PR, V75, P235, DOI 10.1016/j.diabres.2006.06.019
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   Das UN, 2004, CURR HYPERTENS REP, V6, P66, DOI 10.1007/s11906-004-0014-8
   FERRANNINI E, 1991, DIABETOLOGIA, V34, P416, DOI 10.1007/BF00403180
   Ford ES, 2003, DIABETES CARE, V26, P575, DOI 10.2337/diacare.26.3.575
   Fröhlich M, 2000, DIABETES CARE, V23, P1835, DOI 10.2337/diacare.23.12.1835
   Giugliano D, 2000, NUTR METAB CARDIOVAS, V10, P38
   GIUGLIANO D, 1995, METABOLISM, V44, P363, DOI 10.1016/0026-0495(95)90167-1
   HEINRICH PC, 1990, BIOCHEM J, V265, P621, DOI 10.1042/bj2650621
   Karaouzene N, 2011, NUTR METAB CARDIOVAS, V21, P792, DOI 10.1016/j.numecd.2010.02.007
   Kolovou GD, 2007, AM J MED SCI, V333, P362, DOI 10.1097/MAJ.0b013e318065c3a1
   Lapenna D, 2001, FREE RADICAL BIO MED, V31, P331, DOI 10.1016/S0891-5849(01)00584-6
   Luc G, 2003, ARTERIOSCL THROM VAS, V23, P1255, DOI 10.1161/01.ATV.0000079512.66448.1D
   MARKLUND S, 1974, EUR J BIOCHEM, V47, P469
   Matsuzawa Y, 2004, ARTERIOSCL THROM VAS, V24, P29, DOI 10.1161/01.ATV.0000099786.99623.EF
   PAGLIA DE, 1967, J LAB CLIN MED, V70, P158
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Pearson TA, 2003, CIRCULATION, V107, P499, DOI 10.1161/01.CIR.0000052939.59093.45
   Penckofer Sue, 2002, J Cardiovasc Nurs, V16, P68
   Ridker PM, 2000, CIRCULATION, V101, P1767, DOI 10.1161/01.CIR.101.15.1767
   Ryo M, 2004, CIRC J, V68, P975, DOI 10.1253/circj.68.975
   Shoelson SE, 2007, GASTROENTEROLOGY, V132, P2169, DOI 10.1053/j.gastro.2007.03.059
   Stocker R, 2004, PHYSIOL REV, V84, P1381, DOI 10.1152/physrev.00047.2003
   West IC, 2000, DIABETIC MED, V17, P171, DOI 10.1046/j.1464-5491.2000.00259.x
   Yeh CJ, 2011, ASIA PAC J CLIN NUTR, V20, P292
NR 30
TC 58
Z9 67
U1 0
U2 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 19
PY 2012
VL 7
IS 9
AR e45693
DI 10.1371/journal.pone.0045693
PG 5
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 014PP
UT WOS:000309388400121
PM 23029185
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Venturini, D
   Simao, ANC
   Scripes, NA
   Bahls, LD
   Melo, PAS
   Belinetti, FM
   Lozovoy, MAB
   Dichi, I
AF Venturini, Danielle
   Simao, Andrea N. C.
   Scripes, Nicole A.
   Bahls, Larissa D.
   Melo, Petronio A. S.
   Belinetti, Francine M.
   Lozovoy, Marcell A. B.
   Dichi, Isaias
TI Evaluation of Oxidative Stress in Overweight Subjects With or Without
   Metabolic Syndrome
SO OBESITY
LA English
DT Article
ID INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; PROTEIN PRODUCTS; URIC-ACID;
   OBESITY; INFLAMMATION; BLOOD; IMPACT; ASSAY; RISK
AB Although oxidative stress is considered the underlying mechanism by which dysfunctional metabolism occurs in obese subjects, there are few studies on oxidative stress in overweight subjects. The objective of this study was to verify the influence of metabolic syndrome (MetS) on oxidative stress and antioxidant defense in overweight subjects. There were 123 subjects (50 in the control group and 73 in the overweight group) chosen to participate in this cross-sectional study. The control group included 50 healthy individuals with a BMI between 20 and 24.9 kg/m(2) and without MetS. The overweight group included 73 subjects with a BMI between 25 and 29.9 kg/m(2). Overweight subjects were divided into two groups: with MetS (29 subjects) and without MetS (44 subjects). Control group and overweight group subjects without MetS showed no differences in oxidative stress parameters and total antioxidant capacity (TRAP). Overweight subjects with MetS had higher hydroperoxide concentrations measured by chemiluminescence compared to the control group (P < 0.05), higher hydroperoxide and hydrogen peroxide concentrations determined by ferrous oxidation-xylenol orange assay compared to overweight subjects without MetS (P < 0.001), and higher advanced oxidation protein product (AOPP) concentrations (P < 0.001) compared to the other groups. AOPP was directly correlated with uric acid concentrations. Overweight subjects with MetS had lower TRAP concentrations compared to the control group (P < 0.001). In conclusion, this study showed that overweight subjects with MetS, in contrast to overweight subjects without MetS, have a redox imbalance characterized by increased plasma oxidation and reduced antioxidant capacity.
C1 [Venturini, Danielle; Simao, Andrea N. C.; Scripes, Nicole A.; Bahls, Larissa D.] Univ Londrina, Dept Pathol Clin Anal & Toxicol, Londrina, Brazil.
   [Melo, Petronio A. S.; Belinetti, Francine M.; Dichi, Isaias] Univ Londrina, Dept Internal Med, Londrina, Brazil.
   [Lozovoy, Marcell A. B.] Univ N Parana UNOPAR, Dept Clin Anal, Londrina, Brazil.
C3 University Norte Parana
RP Simao, ANC (corresponding author), Univ Londrina, Dept Pathol Clin Anal & Toxicol, Londrina, Brazil.
EM dcianame@yahoo.com.br
RI Venturini, Danielle/HPH-1330-2023; Simão, Andrea/AAM-4892-2021; Lozovoy,
   Marcell/AAM-4897-2021; Melo, Petronio Augusto de Souza/J-7678-2018
OI Melo, Petronio Augusto de Souza/0000-0003-0726-3172; Bahls Pinto,
   Larissa Danielle/0000-0001-6469-3123
FU Research Funds of University of Londrina (FAEPE)
FX This study was financially supported by Research Funds of University of
   Londrina (FAEPE).
CR Abdilla N, 2007, J HUM HYPERTENS, V21, P68, DOI 10.1038/sj.jhh.1002105
   Ando K, 2009, FREE RADICAL BIO MED, V47, P213, DOI 10.1016/j.freeradbiomed.2009.04.030
   Casado MF, 2007, FOOD CHEM TOXICOL, V45, P945, DOI 10.1016/j.fct.2006.12.001
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Ceriello A, 2000, METABOLISM, V49, P27, DOI 10.1016/S0026-0495(00)80082-7
   Simao ANC, 2008, NUTRITION, V24, P675, DOI 10.1016/j.nut.2008.03.021
   Simao ANC, 2010, ARQ BRAS ENDOCRINOL, V54, P540, DOI 10.1590/S0004-27302010000600005
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   FLECHA BG, 1991, FREE RADICAL BIO MED, V10, P93
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Fujita K, 2006, CIRC J, V70, P1437, DOI 10.1253/circj.70.1437
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Haffner SM, 2003, AM J CARDIOL, V92, p18J, DOI 10.1016/S0002-9149(03)00612-X
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Holme I, 2009, J INTERN MED, V266, P558, DOI 10.1111/j.1365-2796.2009.02133.x
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jacobs Jr DR, 2001, JAMA-J AM MED ASSOC, V285, P2486
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Krzystek-Korpacka M, 2008, CLIN BIOCHEM, V41, P943, DOI 10.1016/j.clinbiochem.2008.04.024
   Lavoie ME, 2011, J DIABETES METAB, V2, DOI 10.4172/d155-6156.1000136
   Lee KU, 2001, DIABETES RES CLIN PR, V54, pS29, DOI 10.1016/S0168-8227(01)00332-1
   Meisinger C, 2008, ARTERIOSCL THROM VAS, V28, P1186, DOI 10.1161/ATVBAHA.107.160184
   NOUROOZZADEH J, 1994, ANAL BIOCHEM, V220, P403, DOI 10.1006/abio.1994.1357
   Ohmori K, 2005, ANN EPIDEMIOL, V15, P80, DOI 10.1016/j.annepidem.2004.04.001
   Piwowar A, 2007, DIABETES RES CLIN PR, V77, P188, DOI 10.1016/j.diabres.2006.12.007
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Repetto M, 1996, CLIN CHIM ACTA, V255, P107, DOI 10.1016/0009-8981(96)06394-2
   Santos AC, 2005, INT J OBESITY, V29, P1452, DOI 10.1038/sj.ijo.0803035
   Skalicky J, 2008, CLIN CHEM LAB MED, V46, P499, DOI 10.1515/CCLM.2008.096
   Urakawa H, 2003, J CLIN ENDOCR METAB, V88, P4673, DOI 10.1210/jc.2003-030202
   Wilson PWF, 2002, ARCH INTERN MED, V162, P1867, DOI 10.1001/archinte.162.16.1867
   WitkoSarsat V, 1996, KIDNEY INT, V49, P1304, DOI 10.1038/ki.1996.186
NR 33
TC 40
Z9 43
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD DEC
PY 2012
VL 20
IS 12
BP 2361
EP 2366
DI 10.1038/oby.2012.130
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 045QX
UT WOS:000311713000006
PM 22592332
OA Bronze
DA 2025-06-11
ER

PT J
AU Levinger, I
   Selig, S
   Goodman, C
   Jerums, G
   Stewart, A
   Hare, DL
AF Levinger, Itamar
   Selig, Steve
   Goodman, Craig
   Jerums, George
   Stewart, Andrew
   Hare, David L.
TI RESISTANCE TRAINING IMPROVES DEPRESSIVE SYMPTOMS IN INDIVIDUALS AT HIGH
   RISK FOR TYPE 2 DIABETES
SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
LA English
DT Article
DE cardiac depression scale; depressed mood; metabolic risk factors; weight
   training
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; VALIDATION; OVERWEIGHT; EXERCISE;
   SCALE
AB Levinger, I, Selig, S, Goodman, C, Jerums, G, Stewart, A, and Hare, DL. Resistance training improves depressive symptoms in individuals at high risk for type 2 diabetes. J Strength Cond Res 25(8): 2328-2333, 2011-Depression is more prevalent in obese individuals and those with diabetes, compared to the general population. This study examined the effect of resistance training on depressed mood in individuals with high (HiMF, n >= 2) and low (LoMF, n <= 1) numbers of risk factors for metabolic syndrome and type 2 diabetes. The primary hypothesis was that resistance training would significantly reduce depressed mood, as measured by the Cardiac Depression Scale (CDS), in individuals with HiMF. Fifty-five middle-aged volunteers (50.8 +/- 0.9 years, mean +/- SEM) from the general community participated in the study. After initial allocation to HiMF or LoMF, participants were randomly allocated to 4 groups, HiMF training (HiMFT), HiMF control (HiMFC), LoMF training (LoMFT), and LoMF control (LoMFC). Participants underwent resistance training involving major muscle groups on 3 d.wk(-1) for 10 weeks. Before and after interventions (training or control), participants completed the CDS to assess change in the level of depressed mood. Following resistance training, the CDS score of the HiMFT group was reduced by -14.8 +/- 4.9 points on the CDS, a significant improvement in comparison to both baseline (p = 0.01) and HiMFC (p = 0.049) values. No significant change was observed for LoMFT. In the HiMF group only, the percent change in relative muscle strength was correlated with the Delta change in CDS; r = 20.46, p = 0.008. Resistance exercise training programs that consist 7 exercises for the major muscle groups at both low-moderate and moderate-high intensities appear to alleviate depressed mood in individuals with clusters of metabolic risk factors.
C1 [Levinger, Itamar; Selig, Steve; Goodman, Craig] Victoria Univ, Inst Sport Exercise & Act Living, Sch Sport & Exercise Sci, Melbourne, Vic 8001, Australia.
   [Jerums, George] Univ Melbourne, Dept Endocrinol, Melbourne, Vic, Australia.
   [Stewart, Andrew; Hare, David L.] Univ Melbourne, Dept Cardiol, Melbourne, Vic, Australia.
C3 Victoria University; University of Melbourne; University of Melbourne
RP Levinger, I (corresponding author), Victoria Univ, Inst Sport Exercise & Act Living, Sch Sport & Exercise Sci, Melbourne, Vic 8001, Australia.
EM itamar.levinger@vu.edu.au
RI Goodman, Craig/H-8085-2019
OI Goodman, Craig/0000-0002-5874-7743; Hare, David
   Linley/0000-0001-9554-6556; Levinger, Itamar/0000-0001-9194-2033
CR Astle F, 2007, NURS CLIN N AM, V42, P67, DOI 10.1016/j.cnur.2006.11.007
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   Birks Y, 2004, BRIT J HEALTH PSYCH, V9, P15, DOI 10.1348/135910704322778696
   BLAND JM, 1986, LANCET, V1, P307, DOI 10.1016/s0140-6736(86)90837-8
   Bray GA, 2004, J CLIN ENDOCR METAB, V89, P2583, DOI 10.1210/jc.2004-0535
   Ellingson T, 2000, J Gerontol Nurs, V26, P17
   Fontaine KR, 1996, J FAM PRACTICE, V43, P265
   Fox KR, 1999, PUBLIC HEALTH NUTR, V2, P411, DOI 10.1017/S1368980099000567
   Hare DL, 1996, J PSYCHOSOM RES, V40, P379, DOI 10.1016/0022-3999(95)00612-5
   Kaukua J, 2003, INT J OBESITY, V27, P1233, DOI 10.1038/sj.ijo.0802379
   Kottke TE, 2003, MAYO CLIN PROC, V78, P92, DOI 10.4065/78.1.92
   Levinger I, 2008, MED SCI SPORT EXER, V40, P535, DOI [10.1249/mss.0b013e31815dd057, 10.1249/MSS.0b013e31815dd057]
   Levinger I, 2007, DIABETES CARE, V30, P2205, DOI 10.2337/dc07-0841
   Levinger I, 2009, J SCI MED SPORT, V12, P310, DOI 10.1016/j.jsams.2007.10.007
   MCHORNEY CA, 1993, MED CARE, V31, P247, DOI 10.1097/00005650-199303000-00006
   Miranda PJ, 2005, AM HEART J, V149, P33, DOI 10.1016/j.ahj.2004.07.013
   Must A, 1999, JAMA-J AM MED ASSOC, V282, P1523, DOI 10.1001/jama.282.16.1523
   Nishijima H, 2007, MED SCI SPORT EXER, V39, P926, DOI 10.1249/mss.0b013e3180383d84
   Reaven GM, 2006, AM J CLIN NUTR, V83, P1237, DOI 10.1093/ajcn/83.6.1237
   Shi WY, 2008, EUR HEART J, V29, pS745
   Singh NA, 2001, J GERONTOL A-BIOL, V56, pM497, DOI 10.1093/gerona/56.8.M497
   SNAITH P, 1993, BRIT J PSYCHIAT, V163, P293, DOI 10.1192/bjp.163.3.293
   Stein MB, 2006, PSYCHOL MED, V36, P587, DOI 10.1017/S0033291706007239
   Stunkard AJ, 2003, BIOL PSYCHIAT, V54, P330, DOI 10.1016/S0006-3223(03)00608-5
   Wang W, 2008, J PSYCHOSOM RES, V65, P123, DOI 10.1016/j.jpsychores.2008.03.010
   Ware JE, 1997, SF-36 physical and mental health summary scales a user's manual
   Weeks DL, 2007, EVAL HEALTH PROF, V30, P254, DOI 10.1177/0163278707304043
   Zimmet PZ, 2005, MED J AUSTRALIA, V183, P175, DOI 10.5694/j.1326-5377.2005.tb06987.x
NR 28
TC 15
Z9 18
U1 0
U2 25
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1064-8011
EI 1533-4287
J9 J STRENGTH COND RES
JI J. Strength Cond. Res.
PD AUG
PY 2011
VL 25
IS 8
BP 2328
EP 2333
DI 10.1519/JSC.0b013e3181f8fd4a
PG 6
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Sport Sciences
GA 796PH
UT WOS:000293063500036
PM 21659891
OA Bronze
DA 2025-06-11
ER

PT J
AU McPherson, S
   Gosrani, S
   Hogg, S
   Patel, P
   Wetten, A
   Welton, R
   Hallsworth, K
   Campbell, M
AF McPherson, Stuart
   Gosrani, Shion
   Hogg, Sarah
   Patel, Preya
   Wetten, Aaron
   Welton, Rachael
   Hallsworth, Kate
   Campbell, Matthew
TI Increased cardiovascular risk and reduced quality of life are highly
   prevalent among individuals with hepatitis C
SO BMJ OPEN GASTROENTEROLOGY
LA English
DT Article
ID MANIFESTATIONS; STATINS
AB Objective Hepatitis C virus (HCV) infection is common. Although treatment is effective, with oral antivirals curing >95% of patients, most individuals have comorbidities that persist long term. Therefore, our aim was to determine the prevalence of potentially modifiable health problems in patients with HCV and develop an HCV care bundle to identify and target comorbidities.
   Design Cross-sectional, observational single-centre study that recruited consecutive patients with HCV from our viral hepatitis clinics. Data were collected on cardiovascular (CV) risk factors, lifestyle behaviours, anthropometry and health-related quality of life (HRQoL). QRISK 3 was used to predict 10-year CV event risk.
   Results 100 patients were recruited (67% male, 93% white, median age 52 years (range 24-80); 71% were treated for HCV; 34% had cirrhosis; 14% had diabetes; 61% had hypertension; 31% had metabolic syndrome; and 54% were smokers). The median 10-year CV event risk was 8.3% (range 0.3%-63%). 45% had a predicted 10-year CV event risk of >10%. Only 10% of individuals were treated with statins and 27% with antihypertensives. 92% had a predicted 'heart age' greater than their chronological age (median difference +7 (-4 to +26) years). HRQoL was reduced in all SF36v2 domains in the cohort. Factors independently associated with HRQoL included cirrhosis, metabolic syndrome, history of mental health disorder, sedentary behaviour and HCV viraemia.
   Conclusion A large proportion of patients with HCV presented with increased risk of CV events, and rates of smoking and sedentary behaviour were high, while prescribing of primary prophylaxis was infrequent. HRQoL was also reduced in the cohort. A 'care bundle' was developed to provide a structured approach to treating potentially modifiable health problems.
C1 [McPherson, Stuart; Gosrani, Shion; Hogg, Sarah; Patel, Preya; Wetten, Aaron; Welton, Rachael; Hallsworth, Kate] Newcastle Tyne Hosp NHS Fdn Trust, Liver Unit, Newcastle Upon Tyne, Tyne & Wear, England.
   [McPherson, Stuart; Hallsworth, Kate] Newcastle Univ, Translat & Clin Res Inst, Newcastle Upon Tyne, Tyne & Wear, England.
   [Campbell, Matthew] Univ Leeds, Sch Food Sci & Nutr, Leeds, W Yorkshire, England.
   [Campbell, Matthew] Univ Leeds, Leeds Inst Cardiovasc & Metab Med, Leeds, W Yorkshire, England.
C3 Newcastle Upon Tyne Hospitals NHS Foundation Trust; Newcastle University
   - UK; University of Leeds; University of Leeds
RP McPherson, S (corresponding author), Newcastle Tyne Hosp NHS Fdn Trust, Liver Unit, Newcastle Upon Tyne, Tyne & Wear, England.; McPherson, S (corresponding author), Newcastle Univ, Translat & Clin Res Inst, Newcastle Upon Tyne, Tyne & Wear, England.
EM stuart.mcpherson2@nhs.net
RI Wetten, Aaron/GZK-6848-2022; Campbell, Matthew/AAZ-2997-2021
OI McPherson, Stuart/0000-0002-5638-2453; Patel, Preya/0000-0002-2433-6794;
   Hallsworth, Kate/0000-0002-1860-6970; Campbell,
   Matthew/0000-0001-5883-5041
FU LIVErNORTH Charity
FX LIVErNORTH Charity.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   [Anonymous], PUBL HLTH GUID PH38
   Badawi A, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0208839
   Barreira DP, 2019, FRONT PSYCHOL, V9, DOI 10.3389/fpsyg.2018.02666
   Batchelder AW, 2015, DRUG ALCOHOL DEPEN, V153, P66, DOI 10.1016/j.drugalcdep.2015.06.007
   Butt AA, 2020, CLIN INFECT DIS, V70, P1153, DOI 10.1093/cid/ciz304
   Butt AA, 2019, GASTROENTEROLOGY, V156, P987, DOI 10.1053/j.gastro.2018.11.022
   Butt AA, 2015, HEPATOLOGY, V62, P365, DOI 10.1002/hep.27835
   Carusone SC, 2019, HARM REDUCT J, V16, DOI 10.1186/s12954-019-0285-7
   Chen Y, 2020, DIGEST DIS SCI, V65, P1940, DOI 10.1007/s10620-019-05918-7
   Corica F, 2008, INT J OBESITY, V32, P185, DOI 10.1038/sj.ijo.0803687
   Cossais S, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0215596
   Drazilova S, 2018, CAN J GASTROENTEROL, V2018, DOI 10.1155/2018/6095097
   Dyson JK, 2016, ALIMENT PHARM THER, V44, P1030, DOI 10.1111/apt.13806
   Elsharkawy AM, 2013, FRONTLINE GASTROENTE, V4, P125, DOI 10.1136/flgastro-2012-100282
   European Assoc Study Liver, 2018, J HEPATOL, V69, P461, DOI 10.1016/j.jhep.2018.03.026
   Fabiani S, 2018, REV ENDOCR METAB DIS, V19, P405, DOI 10.1007/s11154-017-9440-1
   Freeman AJ, 2001, HEPATOLOGY, V34, P809, DOI 10.1053/jhep.2001.27831
   Innes HA, 2011, HEPATOLOGY, V54, P2281, DOI [10.1002/hep.24776, 10.1002/hep.24561]
   Janicko M, 2016, WORLD J GASTROENTERO, V22, P6201, DOI 10.3748/wjg.v22.i27.6201
   Lee KK, 2019, LANCET GASTROENTEROL, V4, P794, DOI 10.1016/S2468-1253(19)30227-4
   Louie KS, 2012, BMC INFECT DIS, V12, DOI 10.1186/1471-2334-12-86
   Maruish M., 2011, Users manual for the SF36v2 Health Survey
   Maticic M, 2020, CLIN MICROBIOL INFEC, V26, P818, DOI 10.1016/j.cmi.2020.01.014
   McPherson S, 2016, FRONTLINE GASTROENTE, V7, P16, DOI 10.1136/flgastro-2014-100491
   National Institute for Health and Clinical Excellence (NICE), 2009, CLIN GUID CG90 DEPR
   NHS Digital, 2019, STAT SMOK
   NICE, 2016, CLIN GUID NG50 ASS M
   NICE, 2011, CLIN GUID CG 115 ALC
   NICE, 2016, CLIN GUID CG18 LIP M
   NICE, 2019, CLIN GUID NG136 HYP
   PHE, 2019, HEP C ENGL
   Rossi C, 2019, J HEPATOL, V71, P1116, DOI 10.1016/j.jhep.2019.07.021
   SAUNDERS JB, 1993, ADDICTION, V88, P791, DOI 10.1111/j.1360-0443.1993.tb02093.x
   Serfaty L, 2017, CLIN LIVER DIS, V21, P475, DOI 10.1016/j.cld.2017.03.004
   Simpson H, 2019, J PUBLIC HEALTH-UK, V41, P700, DOI 10.1093/pubmed/fdy190
   UK Government, 2019, English indices of deprivation
   Westbrook RH, 2014, J HEPATOL, V61, pS58, DOI 10.1016/j.jhep.2014.07.012
   World Health Organization, 2016, GLOBAL HLTH SECTOR S
   World Health Organization, 2017, World malaria report
   Younossi Z, 2016, GASTROENTEROLOGY, V150, P1599, DOI 10.1053/j.gastro.2016.02.039
   Younossi ZM, 2019, LIVER INT, V39, P54, DOI 10.1111/liv.13900
NR 42
TC 11
Z9 13
U1 0
U2 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2054-4774
J9 BMJ OPEN GASTROENTER
JI BMJ Open Gastroenterol.
PY 2020
VL 7
IS 1
AR e000470
DI 10.1136/bmjgast-2020-000470
PG 10
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA QJ7NV
UT WOS:000619873900001
PM 32847899
OA Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Haam, JH
   Lee, YK
   Suh, E
   Choi, SW
   Chun, H
   Kim, YS
AF Haam, Ji-Hee
   Lee, Yun Kyong
   Suh, Eunkyung
   Choi, Sang-Woon
   Chun, Hyejin
   Kim, Young-Sang
TI Urine organic acids may be useful biomarkers for metabolic syndrome and
   its components in Korean adults
SO CLINICAL CHEMISTRY AND LABORATORY MEDICINE
LA English
DT Article
DE insulin resistance; metabolic syndrome; metabolomics; urine organic acid
ID INSULIN-RESISTANCE; BETA-HYDROXYBUTYRATE; AMINO-ACIDS; STRESS;
   DETERMINANTS; HISTIDINE; THERAPY; PATHWAY; OBESITY; PROFILE
AB Objectives: Although metabolic syndrome (MetS) and its components are defined clinically, those with MetS may have various derangements in metabolic pathways. Thus, this study aimed to evaluate the traits of urine organic acid metabolites indicating the metabolic intermediates of the pathways in the subjects with MetS.
   Methods: This cross-sectional study included 246 men and 283 women in a hospital health check-up setting. Urine organic acid metabolites were assayed via high-performance liquid chromatography-mass spectrometry analyses. A high level of each metabolite was defined as the fifth quintile of the distribution.
   Results: The subjects with MetS had high levels of pyruvate, alpha-ketoglutarate, alpha-ketoisovalerate, alpha-ketoisocaproate, formiminoglutamate, and quinolinate (odds ratios from 1.915 to 2.809 in logistic models adjusted for age and sex). Among the metabolites, pyruvate, formiminoglutamate, and quinolinate were not independent of homeostatic model assessment of insulin resistance (HOMA2-IR). Several metabolites were associated with one or more components of MetS and HOMA2-IR.
   Conclusions: Urine organic acid metabolites in MetS are characterized in altered carbohydrate and amino acid metabolism. MetS shared some traits in insulin resistance. These findings may promote the understanding of the pathophysiology of MetS.
C1 [Kim, Young-Sang] CHA Univ, Dept Family Med, CHA Bundang Med Ctr, 59 Yatap Ro, Seongnam Si 13496, Gyeonggi Do, South Korea.
   [Haam, Ji-Hee; Lee, Yun Kyong; Suh, Eunkyung; Choi, Sang-Woon] CHA Univ, Chaum Life Ctr, Seoul, South Korea.
   [Chun, Hyejin] CHA Univ, CHA Bundang Med Ctr, Dept Family Med, Seongnam, South Korea.
C3 Pochon Cha University; Pochon Cha University; Pochon Cha University
RP Kim, YS (corresponding author), CHA Univ, Dept Family Med, CHA Bundang Med Ctr, 59 Yatap Ro, Seongnam Si 13496, Gyeonggi Do, South Korea.
EM zeroup@cha.ac.kr
OI Kim, Young-Sang/0000-0002-7397-5410
FU Yuhan Co, Ltd. [2020-02-020]; Academic Fund from CHA university
FX This study was supported by Yuhan Co, Ltd. [grant number 2020-02-020]
   and Academic Fund from CHA university.
CR ADIBI SA, 1968, J APPL PHYSIOL, V25, P52, DOI 10.1152/jappl.1968.25.1.52
   Bloomgarden Z, 2018, J DIABETES, V10, P350, DOI 10.1111/1753-0407.12645
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Campbell BM, 2014, FRONT NEUROSCI-SWITZ, V8, DOI 10.3389/fnins.2014.00012
   Chakraborty S, 2018, CELL REP, V25, P677, DOI 10.1016/j.celrep.2018.09.058
   Clària J, 2019, HEPATOLOGY, V69, P1686, DOI 10.1002/hep.30363
   Edwardson CL, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034916
   Favennec M, 2015, OBESITY, V23, P2066, DOI 10.1002/oby.21199
   Gallagher RC, 2018, GENET MED, V20, P683, DOI 10.1038/gim.2018.45
   Gluvic Z, 2017, CURR VASC PHARMACOL, V15, P30, DOI 10.2174/1570161114666161007164510
   Holecek M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12103087
   Holecek M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030848
   JACKSON S, 1991, PEDIATR RES, V29, P406, DOI 10.1203/00006450-199104000-00016
   Lee YT, 2005, EUR J PHARMACOL, V513, P145, DOI 10.1016/j.ejphar.2005.02.010
   LEVY G, 1986, FASEB J, V45, P2235
   Li JC, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-09522-5
   Li Y, 2013, J BIOL CHEM, V288, P9583, DOI 10.1074/jbc.M112.431627
   Lteif AA, 2005, CIRCULATION, V112, P32, DOI 10.1161/CIRCULATIONAHA.104.520130
   Lugo-Huitrón R, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/104024
   LUHBY AL, 1959, AM J CLIN NUTR, V7, P397, DOI 10.1093/ajcn/7.4.397
   Maddux BA, 2001, DIABETES, V50, P404, DOI 10.2337/diabetes.50.2.404
   Maida A, 2017, MOL METAB, V6, P873, DOI 10.1016/j.molmet.2017.06.009
   MARKAVERICH BM, 1988, J BIOL CHEM, V263, P7203
   Matsuoka T, 1997, J CLIN INVEST, V99, P144, DOI 10.1172/JCI119126
   Morgan TM, 2009, CURR CANCER DRUG TAR, V9, P237, DOI 10.2174/156800909787580999
   Moro J, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051414
   Murphy M, 2018, CLIN BIOCH E BOOK IL, V6th
   MUTING D, 1985, LANCET, V2, P1365
   NAKAZONO K, 1991, P NATL ACAD SCI USA, V88, P10045, DOI 10.1073/pnas.88.22.10045
   Nie CX, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19040954
   Ntzouvani A, 2017, NUTR METAB CARDIOVAS, V27, P1021, DOI 10.1016/j.numecd.2017.07.006
   OHARA Y, 1993, J CLIN INVEST, V91, P2546, DOI 10.1172/JCI116491
   Pollex RL, 2006, NAT CLIN PRACT CARD, V3, P482, DOI 10.1038/ncpcardio0638
   Qiu CF, 2014, DIABETES RES CLIN PR, V104, P393, DOI 10.1016/j.diabres.2014.03.001
   Rahimi Y, 2014, P NATL ACAD SCI USA, V111, P16508, DOI 10.1073/pnas.1419104111
   Ramakrishanan N, 2018, J DIABETES COMPLICAT, V32, P791, DOI 10.1016/j.jdiacomp.2018.05.014
   Reddy P, 2018, J DIABETES COMPLICAT, V32, P465, DOI 10.1016/j.jdiacomp.2018.02.005
   Rudich A, 1998, DIABETES, V47, P1562, DOI 10.2337/diabetes.47.10.1562
   Scolamiero E, 2015, MOL BIOSYST, V11, P1525, DOI 10.1039/c4mb00729h
   Setola E, 2004, EUR J ENDOCRINOL, V151, P483, DOI 10.1530/eje.0.1510483
   Sonnenberg GE, 2004, OBES RES, V12, P180, DOI 10.1038/oby.2004.24
   Sun JC, 2013, PERS MED, V10, P149, DOI [10.2217/pme.13.8, 10.2217/PME.13.8]
   Sun XW, 2014, BRIT J NUTR, V112, P477, DOI 10.1017/S0007114514001056
   Sypniewska Grazyna, 2007, EJIFCC, V18, P39
   Tai ES, 2010, DIABETOLOGIA, V53, P757, DOI 10.1007/s00125-009-1637-8
   van den Berg EH, 2019, NUTRIENTS, V11, DOI 10.3390/nu11030705
   Wilson PWF, 2005, CIRCULATION, V112, P3066, DOI 10.1161/CIRCULATIONAHA.105.539528
   Wu N, 2016, BIOMOL THER, V24, P1, DOI 10.4062/biomolther.2015.078
   Youm YH, 2015, NAT MED, V21, P263, DOI 10.1038/nm.3804
   Yu E, 2018, CLIN CHEM, V64, P1211, DOI 10.1373/clinchem.2018.288720
NR 50
TC 3
Z9 3
U1 1
U2 9
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1434-6621
EI 1437-4331
J9 CLIN CHEM LAB MED
JI Clin. Chem. Lab. Med.
PD OCT
PY 2021
VL 59
IS 11
BP 1824
EP 1831
DI 10.1515/cclm-2021-0598
PG 8
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA UQ7LQ
UT WOS:000696242800019
PM 34331849
DA 2025-06-11
ER

PT J
AU Leisegang, K
   Henkel, R
   Agarwal, A
AF Leisegang, Kristian
   Henkel, Ralf
   Agarwal, Ashok
TI Obesity and metabolic syndrome associated with systemic inflammation and
   the impact on the male reproductive system
SO AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
LA English
DT Review
DE chronic inflammation; male infertility; metabolic syndrome; obesity;
   spermatogenesis; steroidogenesis
ID BODY-MASS INDEX; URINARY-TRACT SYMPTOMS; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; SEMEN QUALITY; SEMINAL PLASMA; ERECTILE DYSFUNCTION;
   INSULIN-RESISTANCE; TNF-ALPHA; CYTOKINE CONCENTRATIONS
AB Obesity and metabolic syndrome (MetS) are global epidemics, driven by an obesogenic environment. This is mediated by complex underlying pathophysiology, in which chronic inflammation is an important aetiological and mechanistic phenomenon. A shift towards a subclinical T(H)1-lymphocyte mediated innate and chronic inflammatory response is well defined in obesity and MetS, demonstrated in multiple systems including visceral adiposity, brain (hypothalamus), muscles, vasculature, liver, pancreas, testes, epididymis, prostate and seminal fluid. Inflammatory cytokines disrupt the hypothalamic-pituitary-testes axis and steroidogenesis cascades (hypogonadotropic hypogonadism), spermatogenesis (poor semen parameters, including DNA fragmentation and detrimental epigenetic modification) and results in subclinical prostatitis and prostate hyperplasia. This review aims to highlight the role of chronic inflammation in obesity and MetS, cytokines in male reproductive physiology and pathophysiology, the impact on steroidogenesis and spermatogenesis, prostate pathology and erectile dysfunction. Currently, it is recommended that clinical assessment of male infertility and reproductive dysfunction in obese and MetS patients includes inflammation assessment (highly sensitive C-reactive protein), and appropriate advice and therapeutic options are incorporated in the management options. However, the mechanisms and therapeutic options remain poorly understood and require significant interdisciplinary research to identify potential novel therapeutic strategies.
C1 [Leisegang, Kristian] Univ Western Cape, Sch Nat Med, Blanckenberg Rd, Cape Town, South Africa.
   [Henkel, Ralf] Univ Western Cape, Dept Med Biosci, Cape Town, South Africa.
   [Henkel, Ralf; Agarwal, Ashok] Cleveland Clin, Dept Urol, Amer Ctr Reprod Med, Cleveland, OH 44106 USA.
C3 University of the Western Cape; University of the Western Cape;
   Cleveland Clinic Foundation
RP Leisegang, K (corresponding author), Univ Western Cape, Sch Nat Med, Blanckenberg Rd, Cape Town, South Africa.
EM kleisegang@uwc.ac.za
RI Leisegang, Kristian/AAS-3925-2021
OI Leisegang, Kristian/0000-0002-3003-8048; Henkel,
   Ralf/0000-0003-1128-2982
CR Abdel-Fadeil Mahmoud R, 2019, Pathophysiology, V26, P181, DOI 10.1016/j.pathophys.2019.02.001
   Adler MI, 2013, EXP GERONTOL, V48, P539, DOI 10.1016/j.exger.2013.03.007
   Agarwal A, 2006, J ANDROL, V27, P335, DOI 10.2164/jandrol.05136
   Agarwal A, 2018, ARAB J UROL, V16, P77, DOI 10.1016/j.aju.2017.11.008
   Agarwal A, 2017, INVESTIG CLIN UROL, V58, P385, DOI 10.4111/icu.2017.58.6.385
   Aitken RJ, 2006, INT J ANDROL, V29, P69, DOI 10.1111/j.1365-2605.2005.00630.x
   Akbari M, 2018, INFLAMMOPHARMACOLOGY, V26, P899, DOI 10.1007/s10787-018-0508-7
   Akbari M, 2018, NUTR METAB, V15, DOI 10.1186/s12986-018-0274-y
   Al-Asmakh M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0103809
   Alexander RB, 1998, UROLOGY, V52, P744, DOI 10.1016/S0090-4295(98)00390-2
   Alicka M, 2018, STEM CELLS INT, V2018, DOI 10.1155/2018/4274361
   Alves MG, 2014, BRIT J PHARMACOL, V171, P1033, DOI 10.1111/bph.12522
   Guazzone VA, 2009, MICROSC RES TECHNIQ, V72, P620, DOI 10.1002/jemt.20704
   [Anonymous], 2010, WHO Laboratory Manual for the Examination and Processing of Human Semen
   Rosaínz MDA, 2011, J SEX MED, V8, P2017, DOI 10.1111/j.1743-6109.2011.02277.x
   Aslani Z, 2019, BRIT J NUTR, V121, P340, DOI 10.1017/S0007114518003240
   Bakos HW, 2011, FERTIL STERIL, V95, P1700, DOI 10.1016/j.fertnstert.2010.11.044
   Baskaran S, 2019, WORLD J MENS HEALTH, V37, DOI [10.5534/wjmh.18011, DOI 10.5534/WJMH.18011]
   Basu S, 2004, J ANDROL, V25, P250
   Baud D, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.00234
   Bornstein SR, 2004, MOL CELL ENDOCRINOL, V215, P135, DOI 10.1016/j.mce.2003.11.022
   Brie D, 2016, J HYPERTENS, V34, P2318, DOI 10.1097/HJH.0000000000001086
   Brooks GC, 2010, AM J CARDIOL, V106, P56, DOI 10.1016/j.amjcard.2010.02.017
   Camera A, 2008, Minerva Med, V99, P307
   Campos-Silva P, 2015, INT BRAZ J UROL, V41, P569
   Carneiro FS, 2010, J SEX MED, V7, P3823, DOI 10.1111/j.1743-6109.2010.01762.x
   Castro AM., 2017, Revista Medica del Hospital General de Mexico, V80, P101, DOI [10.1016/j.hgmx.2016.06, DOI 10.1016/J.HGMX.2016.06]
   Catanzaro R, 2016, WORLD J GASTROENTERO, V22, P7660, DOI 10.3748/wjg.v22.i34.7660
   Cheng HM, 2017, ATHEROSCLEROSIS, V257, P100, DOI 10.1016/j.atherosclerosis.2017.01.009
   Chia S, 2003, ARTERIOSCL THROM VAS, V23, P695, DOI 10.1161/01.ATV.0000065195.22904.FA
   Cintra DE, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030571
   Corona G, 2010, J SEX MED, V7, P1362, DOI 10.1111/j.1743-6109.2009.01601.x
   Davidson LM, 2015, HUM FERTIL, V18, P184, DOI 10.3109/14647273.2015.1070438
   de Groot PF, 2017, GUT MICROBES, V8, P253, DOI 10.1080/19490976.2017.1293224
   De Nunzio C, 2012, EUR UROL, V61, P560, DOI 10.1016/j.eururo.2011.11.013
   de Oliveira FA, 2019, ASIAN J ANDROL, V21, P201, DOI 10.4103/aja.aja_67_18
   de Tejada IS, 2005, J SEX MED, V2, P26, DOI 10.1111/j.1743-6109.2005.20103.x
   Demirci T, 2019, HISTOL HISTOPATHOL, V34, P287, DOI [10.14680/HH-18-077, 10.14670/HH-18-077]
   di Frega AS, 2005, HUM REPROD, V20, P997, DOI 10.1093/humrep/deh707
   Dohle GR, 2003, WORLD J UROL, V21, P341, DOI 10.1007/s00345-003-0365-9
   Dousset B, 1997, HUM REPROD, V12, P1476, DOI 10.1093/humrep/12.7.1476
   Du Plessis SS, 2010, NAT REV UROL, V7, P153, DOI 10.1038/nrurol.2010.6
   Eggert-Kruse W, 2007, FERTIL STERIL, V87, P810, DOI 10.1016/j.fertnstert.2006.08.103
   Eisenberg ML, 2014, HUM REPROD, V29, P193, DOI 10.1093/humrep/det428
   Espindola RL, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0183501
   Esposito K, 2004, NUTR METAB CARDIOVAS, V14, P228, DOI 10.1016/S0939-4753(04)80048-6
   Fan L, 2017, PHARMACOL RES, V119, P128, DOI 10.1016/j.phrs.2017.01.032
   Fan WM, 2018, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.01117
   Fijak M, 2018, HUM REPROD UPDATE, V24, P416, DOI 10.1093/humupd/dmy009
   Francomano D, 2014, UROLOGY, V83, P167, DOI 10.1016/j.urology.2013.08.019
   Vázquez-Vela MEF, 2008, ARCH MED RES, V39, P715, DOI 10.1016/j.arcmed.2008.09.005
   Gacci M, 2013, PROSTATE CANCER P D, V16, P100, DOI 10.1038/pcan.2012.44
   Gacci M, 2015, BJU INT, V115, P24, DOI 10.1111/bju.12728
   Galic S, 2010, MOL CELL ENDOCRINOL, V316, P129, DOI 10.1016/j.mce.2009.08.018
   Giahi L, 2016, NUTR REV, V74, P118, DOI 10.1093/nutrit/nuv059
   Gómez-Gómez E, 2019, J CELL MOL MED, V23, P934, DOI 10.1111/jcmm.13994
   Gorbachinsky Ilya, 2010, Rev Urol, V12, pe157
   Gratzke C, 2010, J SEX MED, V7, P445, DOI 10.1111/j.1743-6109.2009.01624.x
   Håkonsen LB, 2011, REPROD HEALTH, V8, DOI 10.1186/1742-4755-8-24
   Hales DB, 2002, J REPROD IMMUNOL, V57, P3, DOI 10.1016/S0165-0378(02)00020-7
   Hammoud AO, 2008, FERTIL STERIL, V90, P897, DOI 10.1016/j.fertnstert.2008.08.026
   Hedger MP, 2003, J REPROD IMMUNOL, V58, P1, DOI 10.1016/S0165-0378(02)00060-8
   Henkel R, 2010, ANDROLOGIA, V42, P305, DOI 10.1111/j.1439-0272.2009.01002.x
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Hong CY, 2004, MOL CELL BIOL, V24, P2593, DOI 10.1128/MCB.24.7.2593-2604.2004
   Hu YC, 2017, FOOD CHEM, V220, P1, DOI 10.1016/j.foodchem.2016.09.179
   Jaffar M, 2016, INT J INFERTIL FETAL, V7, P94
   James PT, 2001, OBES RES, V9, p228S, DOI 10.1038/oby.2001.123
   Jensen TK, 2004, FERTIL STERIL, V82, P863, DOI 10.1016/j.fertnstert.2004.03.056
   Juge-Aubry CE, 2005, BEST PRACT RES CL EN, V19, P547, DOI 10.1016/j.beem.2005.07.009
   Karayiannis D, 2017, HUM REPROD, V32, P215, DOI 10.1093/humrep/dew288
   Kasturi SS, 2008, J ANDROL, V29, P251, DOI 10.2164/jandrol.107.003731
   Kefer JC, 2009, INT J UROL, V16, P449, DOI 10.1111/j.1442-2042.2009.02280.x
   Koçak I, 2002, UROL RES, V30, P263, DOI 10.1007/s00240-002-0269-y
   Leisegang K, 2014, ANDROLOGIA, V46, P167, DOI 10.1111/and.12060
   Leisegang K., 2019, OXIDANTS ANTIOXIDANT, P117
   Leisegang K, 2017, CURR PHARM DESIGN, V23, P4438, DOI 10.2174/1381612822666161019150241
   Leisegang K, 2016, AM J REPROD IMMUNOL, V76, P155, DOI 10.1111/aji.12529
   Leisegang K, 2014, REPROD BIOL ENDOCRIN, V12, DOI 10.1186/1477-7827-12-34
   Levinson IP, 2003, INT J IMPOT RES, V15, pS25, DOI 10.1038/sj.ijir.3900970
   Lewis SEM, 2007, REPRODUCTION, V134, P31, DOI 10.1530/REP-07-0152
   Lotti F, 2013, ANDROLOGY-US, V1, P229, DOI 10.1111/j.2047-2927.2012.00031.x
   Lotti F, 2011, INT J ANDROL, V34, P600, DOI 10.1111/j.1365-2605.2010.01121.x
   Lotti F, 2014, ASIAN J ANDROL, V16, P295, DOI 10.4103/1008-682X.122341
   Lotti F, 2013, J REPROD IMMUNOL, V100, P54, DOI 10.1016/j.jri.2013.02.004
   Lumeng CN, 2011, J CLIN INVEST, V121, P2111, DOI 10.1172/JCI57132
   MacDonald AA, 2010, HUM REPROD UPDATE, V16, P293, DOI 10.1093/humupd/dmp047
   Madersbacher S, 2004, EUR UROL, V47, P80
   Maegawa M, 2002, J REPROD IMMUNOL, V54, P33, DOI 10.1016/S0165-0378(01)00063-8
   Magnusdottir EV, 2005, HUM REPROD, V20, P208, DOI 10.1093/humrep/deh569
   Maiorino MI, 2015, ASIAN J ANDROL, V17, P5, DOI 10.4103/1008-682X.137687
   Mallidis C, 2011, REPRODUCTION, V142, P63, DOI 10.1530/REP-10-0472
   Marchetti P, 2012, ANDROLOGIA, V44, P136, DOI 10.1111/j.1439-0272.2010.01117.x
   Marchiani S, 2015, MOL CELL ENDOCRINOL, V401, P12, DOI 10.1016/j.mce.2014.11.005
   Maresch CC, 2018, HUM REPROD UPDATE, V24, P86, DOI 10.1093/humupd/dmx033
   Martínez P, 2007, ASIAN J ANDROL, V9, P102, DOI 10.1111/j.1745-7262.2007.00238.x
   Martins AD, 2019, WORLD J MENS HEALTH, V37, P113, DOI 10.5534/wjmh.180055
   Maruvada P, 2017, CELL HOST MICROBE, V22, P589, DOI 10.1016/j.chom.2017.10.005
   Mazidi M, 2016, DIAB MET SYND CLIN R, V10, pS150, DOI 10.1016/j.dsx.2016.01.024
   McPherson NO, 2015, ASIAN J ANDROL, V17, P450, DOI 10.4103/1008-682X.148076
   Minciullo PL, 2015, UROL INT, V94, P249, DOI 10.1159/000366210
   Moatt JP, 2016, BMC EVOL BIOL, V16, DOI 10.1186/s12862-016-0768-z
   Monteiro R, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/289645
   Moon KH, 2019, WORLD J MENS HEALTH, V37, P138, DOI 10.5534/wjmh.180026
   Morelli A, 2016, MINERVA ENDOCRINOL, V41, P240
   Morelli A, 2014, MOL CELL ENDOCRINOL, V382, P107, DOI 10.1016/j.mce.2013.09.017
   Morelli A, 2012, J STEROID BIOCHEM, V132, P80, DOI 10.1016/j.jsbmb.2012.02.007
   Mosbah R, 2015, EXP TOXICOL PATHOL, V67, P253, DOI 10.1016/j.etp.2015.01.001
   Moul S, 2010, CURR OPIN UROL, V20, P7, DOI 10.1097/MOU.0b013e3283336f3f
   Muller RL, 2013, EUR UROL, V63, P1115, DOI 10.1016/j.eururo.2013.02.038
   Nantia EA, 2009, BASIC CLIN ANDROL, V19, P148, DOI 10.1007/s12610-009-0030-2
   Nieto-Vazquez Iria, 2008, Archives of Physiology and Biochemistry, V114, P183, DOI 10.1080/13813450802181047 
   Nishimura S, 2009, NAT MED, V15, P914, DOI 10.1038/nm.1964
   Nna VU, 2020, ARCH PHYSIOL BIOCHEM, V126, P377, DOI 10.1080/13813455.2018.1543329
   Omer Endashaw, 2017, Curr Gastroenterol Rep, V19, P59, DOI 10.1007/s11894-017-0600-y
   Ozturk U, 2012, SCI WORLD J, DOI 10.1100/2012/985201
   Palmer Nicole O, 2012, Spermatogenesis, V2, P253
   Pilatz A, 2017, ANDROLOGY-US, V5, P23, DOI 10.1111/andr.12296
   Pinte L, 2019, ROM J INTERN MED, V57, P209, DOI 10.2478/rjim-2019-0005
   Politch JA, 2007, HUM REPROD, V22, P2928, DOI 10.1093/humrep/dem281
   Potts JM, 2003, ANDROLOGIA, V35, P304, DOI 10.1046/j.1439-0272.2003.00572.x
   Reis LO, 2012, REPROD SCI, V19, P778, DOI 10.1177/1933719112440053
   Rusz A, 2012, WORLD J UROL, V30, P23, DOI 10.1007/s00345-011-0726-8
   Saisho Y, 2015, ENDOCR METAB IMMUNE, V15, P196, DOI 10.2174/1871530315666150316124019
   Salas-Huetos A, 2017, HUM REPROD UPDATE, V23, P371, DOI 10.1093/humupd/dmx006
   Sanmiguel C, 2015, CURR OBES REP, V4, P250, DOI 10.1007/s13679-015-0152-0
   Scallon B, 2002, J PHARMACOL EXP THER, V301, P418, DOI 10.1124/jpet.301.2.418
   Scheinfeld N, 2004, J Dermatolog Treat, V15, P280
   Sermondade N, 2013, HUM REPROD UPDATE, V19, P221, DOI 10.1093/humupd/dms050
   Sermondade N, 2012, REPROD BIOMED ONLINE, V24, P206, DOI 10.1016/j.rbmo.2011.10.014
   Seshadri S, 2009, AM J REPROD IMMUNOL, V62, P275, DOI 10.1111/j.1600-0897.2009.00736.x
   Singh H, 2019, ENDOCR METAB IMMUNE, V19, P481, DOI 10.2174/1871530319666181130142642
   Sitzmann BD, 2014, AGE, V36, P183, DOI 10.1007/s11357-013-9563-6
   Skurk T, 2007, J CLIN ENDOCR METAB, V92, P1023, DOI 10.1210/jc.2006-1055
   Sohal RS, 1996, SCIENCE, V273, P59, DOI 10.1126/science.273.5271.59
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Stewart TM, 2009, HUM REPROD, V24, P1561, DOI 10.1093/humrep/dep075
   Stokes VJ, 2015, CLIN ENDOCRINOL, V82, P633, DOI 10.1111/cen.12591
   Tabrizi R, 2018, FOOD FUNCT, V9, P6117, DOI 10.1039/c8fo01259h
   Tamakoshi K, 2003, INT J OBESITY, V27, P443, DOI 10.1038/sj.ijo.0802260
   Tavares RS, 2018, REPRODUCTION, V155, pR13, DOI 10.1530/REP-17-0390
   Thaler JP, 2012, J CLIN INVEST, V122, P153, DOI 10.1172/JCI59660
   Thaler JP, 2010, ENDOCRINOLOGY, V151, P4109, DOI 10.1210/en.2010-0336
   Thompson IM, 2005, JAMA-J AM MED ASSOC, V294, P2996, DOI 10.1001/jama.294.23.2996
   Uysal KT, 1997, NATURE, V389, P610, DOI 10.1038/39335
   Vignozzi L, 2012, J ENDOCRINOL, V212, P71, DOI 10.1530/JOE-11-0289
   Walker William H, 2011, Spermatogenesis, V1, P116
   Winter AG, 2014, TRANSL ANDROL UROL, V3, P50, DOI 10.3978/j.issn.2223-4683.2014.01.04
   Wofford Marion R, 2006, J Clin Hypertens (Greenwich), V8, P114, DOI 10.1111/j.1524-6175.2006.04751.x
   Wozniak SE, 2009, DIGEST DIS SCI, V54, P1847, DOI 10.1007/s10620-008-0585-3
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yang XY, 2018, CELL PHYSIOL BIOCHEM, V47, P378, DOI 10.1159/000489918
   Yildirim OG, 2019, TOXICOL MECH METHOD, V29, P224, DOI 10.1080/15376516.2018.1543745
NR 153
TC 85
Z9 91
U1 2
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1046-7408
EI 1600-0897
J9 AM J REPROD IMMUNOL
JI Am. J. Reprod. Immunol.
PD NOV
PY 2019
VL 82
IS 5
AR e13178
DI 10.1111/aji.13178
EA AUG 2019
PG 14
WC Immunology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Reproductive Biology
GA JH5YW
UT WOS:000484297900001
PM 31373727
DA 2025-06-11
ER

PT J
AU Sueta, D
   Koibuchi, N
   Hasegawa, Y
   Toyama, K
   Uekawa, K
   Katayama, T
   Ma, M
   Nakagawa, T
   Ogawa, H
   Kim-Mitsuyama, S
AF Sueta, Daisuke
   Koibuchi, Nobutaka
   Hasegawa, Yu
   Toyama, Kensuke
   Uekawa, Ken
   Katayama, Tetsuji
   Ma, MingJie
   Nakagawa, Takashi
   Ogawa, Hisao
   Kim-Mitsuyama, Shokei
TI Telmisartan Exerts Sustained Blood Pressure Control and Reduces Blood
   Pressure Variability in Metabolic Syndrome by Inhibiting Sympathetic
   Activity
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
DE angiotensin receptor blocker; blood pressure; blood pressure
   variability; hypertension; oxidative stress; sympathetic activity;
   telemetry
ID ROSTRAL VENTROLATERAL MEDULLA; TO-VISIT VARIABILITY; OXIDATIVE STRESS;
   HYPERTENSION; RECEPTOR; OBESITY; SYMPATHOINHIBITION; ACTIVATION; RATS
AB BACKGROUND
   Accumulating evidence on blood pressure (BP) reduction with various angiotensin II receptor blockers (ARBs) show that the magnitudes and durations of BP control differ across ARBs. However, the mechanism of ARBs is unknown. This work was undertaken to compare telmisartan and valsartan in duration of BP control, BP variability, and effects on the autonomic nervous system.
   METHODS
   Using radiotelemetry combined with spectral analysis with a fast Fourier transformation algorithm, we compared the effects of various doses of telmisartan and valsartan on BP and its variability during dark (active phase) and light (inactive phase) periods over 5 weeks in SHR/NDmcr-cp(+/+)(SHRcp) rats, a model of metabolic syndrome. We also compared the effects of these ARBs on autonomic nervous system, central oxidative stress, and inflammation in SHRcp rats.
   RESULTS
   Telmisartan exerted a longer-lasting BP-lowering effect and greater attenuation of BP variability in SHRcp than valsartan. Telmisartan decreased low frequency power of systolic BP and increased spontaneous baroreflex gain in SHRcp during both the dark and light periods more than valsartan. Telmisartan reduced 24-hour urinary norepinephrine excretion more than valsartan. Furthermore, telmisartan attenuated oxidative stress and the numbers of gp91(phox)-positive cells and activated microglia and astrocytes in the rostral ventrolateral medulla of SHRcp rats more than valsartan.
   CONCLUSIONS
   The superiority of telmisartan over valsartan in sustained BP control and reduction of BP variability was attributed to more suppression of sympathetic activity and more improvement of baroreceptor reflex. The greater suppression of sympathetic activity by telmisartan appeared to be partially mediated by a stronger amelioration of central oxidative stress.
C1 [Sueta, Daisuke; Koibuchi, Nobutaka; Hasegawa, Yu; Toyama, Kensuke; Uekawa, Ken; Katayama, Tetsuji; Ma, MingJie; Nakagawa, Takashi; Kim-Mitsuyama, Shokei] Kumamoto Univ, Grad Sch Med Sci, Dept Pharmacol & Mol Therapeut, Kumamoto, Japan.
   [Ogawa, Hisao] Kumamoto Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Kumamoto, Japan.
C3 Kumamoto University; Kumamoto University
RP Kim-Mitsuyama, S (corresponding author), Kumamoto Univ, Grad Sch Med Sci, Dept Pharmacol & Mol Therapeut, Kumamoto, Japan.
EM mitsuyam@gpo.kumamoto-u.ac.jp
RI Sueta, Daisuke/ABG-9809-2021; Nakagawa, Takashi/F-3015-2010; Uekawa,
   Ken/LEM-7766-2024
FU Astellas; AstraZeneca; Bayer; Boehringer Ingelheim; Chugai; Daiichi
   Sankyo; Dainippon Sumitomo Pharma; Eisai; Kowa; Kyowa Hakko Kirin;
   Mitsubishi Tanabe; MSD; Novartis; Otsuka; Pfizer; Sanofi; Sionogi;
   Takeda
FX H.O. received lecture fees and research grant from Astellas,
   AstraZeneca, Bayer, Boehringer Ingelheim, Chugai, Daiichi Sankyo,
   Dainippon Sumitomo Pharma, Eisai, Kowa, Kyowa Hakko Kirin, Mitsubishi
   Tanabe, MSD, Novartis, Otsuka, Pfizer, Sanofi, Sionogi, and Takeda.
   S.K.-M. received lecture fees and research grant from Astellas,
   AstraZeneca, Boehringer Ingelheim, Daiichi Sankyo, Novartis, Sionogi,
   Takeda, and Kyowa Hakko Kirin.
CR Aguzzi A, 2013, SCIENCE, V339, P156, DOI 10.1126/science.1227901
   Boer-Martins L, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-24
   Chrysant SG, 2005, J HUM HYPERTENS, V19, P173, DOI 10.1038/sj.jhh.1001808
   de la Sierra A, 2009, HYPERTENSION, V53, P466, DOI 10.1161/HYPERTENSIONAHA.108.124008
   Dong YF, 2011, HYPERTENSION, V58, P635, DOI 10.1161/HYPERTENSIONAHA.111.173534
   Förstermann U, 2006, CIRCULATION, V113, P1708, DOI 10.1161/CIRCULATIONAHA.105.602532
   Griendling KK, 2000, CIRC RES, V86, P494, DOI 10.1161/01.RES.86.5.494
   Guo F, 2010, CARDIOVASC RES, V87, P578, DOI 10.1093/cvr/cvq059
   Hata J, 2013, CIRCULATION, V128, P1325, DOI 10.1161/CIRCULATIONAHA.113.002717
   Katayama T, 2013, J AM HEART ASSOC, V2, DOI 10.1161/JAHA.113.000197
   Kishi T, 2004, CIRCULATION, V109, P2357, DOI 10.1161/01.CIR.0000128695.49900.12
   Kishi T, 2014, AM J HYPERTENS, V27, P260, DOI 10.1093/ajh/hpt188
   Kishi T, 2012, HYPERTENS RES, V35, P940, DOI 10.1038/hr.2012.63
   Konno S, 2012, J HYPERTENS, V30, P1992, DOI 10.1097/HJH.0b013e328357fa98
   Lacourcière Y, 2004, BLOOD PRESS MONIT, V9, P203, DOI 10.1097/00126097-200408000-00005
   Marina N, 2013, BASIC RES CARDIOL, V108, DOI 10.1007/s00395-012-0317-x
   Michel MC, 2013, PHARMACOL REV, V65, P809, DOI 10.1124/pr.112.007278
   Nagae A, 2009, CIRCULATION, V119, P978, DOI 10.1161/CIRCULATIONAHA.108.824730
   Nagase M, 2007, HYPERTENSION, V50, P877, DOI 10.1161/HYPERTENSIONAHA.107.091058
   Neutel Joel, 2003, J Clin Hypertens (Greenwich), V5, P58, DOI 10.1111/j.1524-6175.2003.01612.x
   Oliveira-Sales EB, 2010, HYPERTENSION, V56, P290, DOI 10.1161/HYPERTENSIONAHA.110.150425
   Palatini P, 2009, CURR HYPERTENS REP, V11, P199, DOI 10.1007/s11906-009-0035-4
   Parati G, 2010, J HYPERTENS, V28, P2177, DOI 10.1097/HJH.0b013e32833e1150
   Pekny M, 2014, NEUROSCI LETT, V565, P30, DOI 10.1016/j.neulet.2013.12.071
   Rothwell PM, 2010, LANCET, V375, P938, DOI 10.1016/S0140-6736(10)60309-1
   Rothwell PM, 2010, LANCET, V375, P895, DOI 10.1016/S0140-6736(10)60308-X
   Sega R, 2005, CIRCULATION, V111, P1777, DOI 10.1161/01.CIR.0000160923.04524.5B
   Sueta D, 2013, J AM HEART ASSOC, V2, DOI 10.1161/JAHA.113.000035
   Sueta D, 2012, AM J HYPERTENS, V25, P704, DOI 10.1038/ajh.2012.26
   Takaya K, 1996, NAT GENET, V14, P130, DOI 10.1038/ng1096-130
   Toyama K, 2014, ARTERIOSCL THROM VAS, V34, P616, DOI 10.1161/ATVBAHA.113.302440
   VERDECCHIA P, 1994, HYPERTENSION, V24, P793, DOI 10.1161/01.HYP.24.6.793
   Verdecchia P, 2012, HYPERTENSION, V60, P34, DOI 10.1161/HYPERTENSIONAHA.112.191858
   White WB, 2008, AM J MED, V121, pS2, DOI 10.1016/j.amjmed.2008.05.016
NR 34
TC 23
Z9 23
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0895-7061
EI 1941-7225
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD DEC
PY 2014
VL 27
IS 12
BP 1464
EP 1471
DI 10.1093/ajh/hpu076
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AU7LM
UT WOS:000345782100005
PM 24871627
OA Bronze
DA 2025-06-11
ER

PT J
AU Ittichaicharoen, J
   Apaijai, N
   Tanajak, P
   Sa-nguanmoo, P
   Chattipakorn, N
   Chattipakorn, S
AF Ittichaicharoen, Jitjiroj
   Apaijai, Nattayaporn
   Tanajak, Pongpan
   Sa-nguanmoo, Piangkwan
   Chattipakorn, Nipon
   Chattipakorn, Siriporn
TI Dipeptidyl peptidase-4 inhibitor enhances restoration of salivary glands
   impaired by obese-insulin resistance
SO ARCHIVES OF ORAL BIOLOGY
LA English
DT Article
DE Insulin; Obesity; Metabolic syndrome; Salivary gland function;
   Mitochondria; DPP-IV inhibitor; Vildagliptin
ID HIGH-FAT DIET; BRAIN MITOCHONDRIAL-FUNCTION; OXIDATIVE STRESS; METABOLIC
   SYNDROME; DIABETES-MELLITUS; RECEPTOR FUNCTION; EPITHELIAL-CELLS; DPP-4
   INHIBITOR; RATS; VILDAGLIPTIN
AB Objective: Chronic high-fat diet consumption causes not only obese- insulin resistance, but also leads to pathological changes in salivary glands, including increased mitochondrial dysfunction, apoptosis, oxidative stress, and inflammation. Dipeptidyl peptidase-4 inhibitor (vildagliptin) is an oral anti-diabetic drug, using for treatment of type 2 diabetes. Vildagliptin has been shown to exert beneficial effects on several organs in cases of obese-insulin resistant condition. However, the effect of vildagliptin on salivary glands impaired by obese-insulin resistance has not been investigated. The hypothesis in this study is that vildagliptin confers beneficial effects on the salivary gland impaired by obese-insulin resistance via decreasing mitochondrial dysfunction, apoptosis, oxidative stress, and inflammation.
   Design: Twenty-four male Wistar rats were divided into two groups. Each group was fed with either a normal (ND; n = 8) or a high fat diet (HFD; n = 16) for 16 weeks. At week 13, the HFD-fed rats were subdivided into 2 subgroups to receive either a vehicle or vildagliptin (3 mg/kg/day) for 28 days via gavage feeding. ND-fed rats were treated with the vehicle. At the end of treatment, metabolic parameters were examined, and rats were killed. Submandibular glands were removed to appraise inflammatory markers, apoptosis and mitochondrial function.
   Results: Vehicle-treated HFD-fed rats developed obese-insulin resistance with an increase in oxidative stress, inflammation, apoptosis, and mitochondrial dysfunction in the salivary glands. Vildagliptin therapy reduced oxidative stress, inflammation, apoptosis and mitochondrial dysfunction in salivary gland of HFD-fed rats.
   Conclusion: Vildagliptin prevented salivary gland injury occurring due to obese-insulin resistance.
C1 [Ittichaicharoen, Jitjiroj; Chattipakorn, Siriporn] Chiang Mai Univ, Fac Dent, Dept Oral Biol & Diagnost Sci, Chiang Mai 50200, Thailand.
   [Ittichaicharoen, Jitjiroj; Apaijai, Nattayaporn; Tanajak, Pongpan; Sa-nguanmoo, Piangkwan; Chattipakorn, Nipon; Chattipakorn, Siriporn] Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Neurophysiol Unit, Chiang Mai 50200, Thailand.
   [Apaijai, Nattayaporn; Tanajak, Pongpan; Sa-nguanmoo, Piangkwan; Chattipakorn, Nipon] Chiang Mai Univ, Fac Med, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai 50200, Thailand.
   [Ittichaicharoen, Jitjiroj; Apaijai, Nattayaporn; Tanajak, Pongpan; Sa-nguanmoo, Piangkwan; Chattipakorn, Nipon; Chattipakorn, Siriporn] Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai 50200, Thailand.
C3 Chiang Mai University; Chiang Mai University; Chiang Mai University;
   Chiang Mai University
RP Chattipakorn, S (corresponding author), Chiang Mai Univ, Fac Dent, Dept Oral Biol & Diagnost Sci, Chiang Mai 50200, Thailand.; Chattipakorn, S (corresponding author), Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Neurophysiol Unit, Chiang Mai 50200, Thailand.
EM scchattipakorn@gmail.com
RI Chattipakorn, Nipon/AAJ-4049-2021; Tanajak, Pongpan/ABB-2347-2020
OI Chattipakorn, Nipon/0000-0003-3026-718X; Sa-nguanmoo,
   Piangkwan/0000-0002-4795-8473; Chattipakorn,
   Siriporn/0000-0003-1677-7052
FU Thailand Research Fund grants [TRF-RTA 6080003]; National Research
   Council of Thailand; CMU50th Anniversary grant by Chiang Mai University
   [PHD/021/2556]; NSTDA Research Chair Grant from the National Science and
   Technology Development Agency Thailand; Chiang Mai University Center of
   Excellence Award
FX This work was supported by Thailand Research Fund grants: TRF-RTA
   6080003 (SCC); the National Research Council of Thailand (SCC); a
   CMU50th Anniversary grant by Chiang Mai University (PHD/021/2556 JI &
   SCC); a NSTDA Research Chair Grant from the National Science and
   Technology Development Agency Thailand (NC) and a Chiang Mai University
   Center of Excellence Award (NC). The authors would like to thank Ms.
   Maria Love for her editorial assistance.
CR Al-Rawi NH, 2011, DIABETES VASC DIS RE, V8, P22, DOI 10.1177/1479164110390243
   Apaijai N, 2016, J ENDOCRINOL, V229, P245, DOI 10.1530/JOE-16-0096
   Apaijai N, 2014, CARDIOVASC DRUG THER, V28, P549, DOI 10.1007/s10557-014-6553-6
   Apaijai N, 2013, BRIT J PHARMACOL, V169, P1048, DOI 10.1111/bph.12176
   Apaijai N, 2012, ENDOCRINOLOGY, V153, P3878, DOI 10.1210/en.2012-1262
   Bonomini F, 2015, AGING DIS, V6, P109, DOI 10.14336/AD.2014.0305
   Bournat Juan C, 2010, Curr Opin Endocrinol Diabetes Obes, V17, P446, DOI 10.1097/MED.0b013e32833c3026
   Denning TL, 2002, FREE RADICAL BIO MED, V33, P1641, DOI 10.1016/S0891-5849(02)01141-3
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Heiskanen KM, 1999, J BIOL CHEM, V274, P5654, DOI 10.1074/jbc.274.9.5654
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Ittichaicharoen J., 2016, APPL PHYSL NUTR META
   Kanazawa I, 2017, DIABETES RES CLIN PR, V123, P9, DOI 10.1016/j.diabres.2016.11.010
   Khan S, 2015, EXPERT OPIN THER TAR, V19, P1607, DOI 10.1517/14728222.2016.1086338
   Kimura S, 2016, METABOLISM, V65, P138, DOI 10.1016/j.metabol.2015.10.030
   Knas M., 2015, J ORAL PATHOLOGY MED
   Martin SS, 2013, J AM COLL CARDIOL, V62, P732, DOI 10.1016/j.jacc.2013.01.079
   Matczuk J, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/8163474
   Muluke M, 2016, J DENT RES, V95, P223, DOI 10.1177/0022034515609882
   Omar BA, 2013, DIABETOLOGIA, V56, P1752, DOI 10.1007/s00125-013-2927-8
   Pintana H, 2013, J ENDOCRINOL, V218, P1, DOI 10.1530/JOE-12-0521
   Pipatpiboon N, 2013, EUR J NEUROSCI, V37, P839, DOI 10.1111/ejn.12088
   Pipatpiboon N, 2012, ENDOCRINOLOGY, V153, P329, DOI 10.1210/en.2011-1502
   Pratchayasakul W, 2011, LIFE SCI, V88, P619, DOI 10.1016/j.lfs.2011.02.003
   Rodrigues L, 2015, ARCH ORAL BIOL, V60, P854, DOI 10.1016/j.archoralbio.2015.02.015
   Shikama Y, 2013, J DENT RES, V92, P540, DOI 10.1177/0022034513487378
   Sripetehwandee J, 2014, ARCH MED RES, V45, P547, DOI 10.1016/j.arcmed.2014.09.002
   Su HX, 2012, J ORAL PATHOL MED, V41, P235, DOI 10.1111/j.1600-0714.2011.01092.x
   Suzuki Mayumi, 2006, J Inflamm (Lond), V3, P11, DOI 10.1186/1476-9255-3-11
   Ujhelyi J, 2014, REGUL PEPTIDES, V194, P23, DOI 10.1016/j.regpep.2014.09.006
   Vollenweider P, 2015, HANDB EXP PHARMACOL, V224, P405, DOI 10.1007/978-3-319-09665-0_12
   Wu YJ, 2015, METABOLISM, V64, P226, DOI 10.1016/j.metabol.2014.08.006
   Yarana C, 2012, LIFE SCI, V90, P808, DOI 10.1016/j.lfs.2012.04.004
   Zalewska A, 2014, ORAL DIS, V20, P560, DOI 10.1111/odi.12173
NR 34
TC 6
Z9 6
U1 0
U2 45
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0003-9969
EI 1879-1506
J9 ARCH ORAL BIOL
JI Arch. Oral Biol.
PD JAN
PY 2018
VL 85
BP 148
EP 153
DI 10.1016/j.archoralbio.2017.10.015
PG 6
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA FR3QY
UT WOS:000418982400019
PM 29073562
DA 2025-06-11
ER

PT J
AU Perez-Cornago, A
   Sanchez-Villegas, A
   Bes-Rastrollo, M
   Gea, A
   Molero, P
   Lahortiga-Ramos, F
   Martinez-Gonzalez, MA
AF Perez-Cornago, Aurora
   Sanchez-Villegas, Almudena
   Bes-Rastrollo, Maira
   Gea, Alfredo
   Molero, Patricio
   Lahortiga-Ramos, Francisca
   Angel Martinez-Gonzalez, Miguel
TI Relationship between adherence to Dietary Approaches to Stop
   Hypertension (DASH) diet indices and incidence of depression during up
   to 8 years of follow-up
SO PUBLIC HEALTH NUTRITION
LA English
DT Article
DE DASH; Depression; Dietary pattern; SUN cohort; Mood
ID SEGUIMIENTO-UNIVERSIDAD; METABOLIC SYNDROME; ASSOCIATION; RISK;
   METAANALYSIS; PATTERN; CORTISOL; DISEASE; QUALITY; SCORES
AB Objective: Our aim was to evaluate the relationship between adherence to different Dietary Approaches to Stop Hypertension (DASH) diet indices and the risk of depression.
   Design: In a prospective study we assessed 14051 participants of a dynamic (permanently ongoing recruitment) prospective cohort (the Seguimiento Universidad de Navarra (SUN) Project), initially free of depression. At baseline, a validated FFQ was used to assess adherence to four previously proposed DASH indices (Dixon, Mellen, Fung and Gunther). To define the outcome we applied two definitions of depression: a less conservative definition including only self-reported physician-diagnosed depression (410 incident cases) and a more conservative definition that required both clinical diagnosis of depression and use of antidepressants (113 incident cases). Cox regression and restricted cubic splines analyses were performed.
   Results: After a median follow-up period of 8 years, the multiple-adjusted model showed an inverse association with the Fung DASH score (hazard ratio (HR)=076; 95 % CI 061, 094) when we used the less conservative definition of depression, and also under the more conservative definition (HR=063; 95 % CI 041, 095). We observed a weak inverse association with the Mellen DASH score, but no statistically significant association was found for the other definitions. The restricted cubic splines analyses suggested that these associations were non-linear (U-shaped).
   Conclusions: Moderate adherence to the DASH diet as operationalized by Fung and Mellen was related to lower depression risk. Since these associations were non-linear, additional prospective studies are required before the results can be generalized and clinical recommendations can be given.
C1 [Perez-Cornago, Aurora; Bes-Rastrollo, Maira; Gea, Alfredo; Angel Martinez-Gonzalez, Miguel] Univ Navarra, Dept Prevent Med & Publ Hlth, C Irunlarrea 1, Pamplona 31008, Spain.
   [Sanchez-Villegas, Almudena] Univ Las Palmas Gran Canaria, Dept Clin Sci, Las Palmas Gran Canaria, Spain.
   [Sanchez-Villegas, Almudena; Bes-Rastrollo, Maira; Gea, Alfredo; Angel Martinez-Gonzalez, Miguel] Inst Hlth Carlos III, Biomed Res Ctr Network Obes & Nutr CIBERobn, Physiopathol Obes & Nutr, Madrid, Spain.
   [Molero, Patricio; Lahortiga-Ramos, Francisca] Univ Clin Navarra, Dept Psychiat & Med Psychol, Pamplona, Spain.
C3 University of Navarra; Universidad de Las Palmas de Gran Canaria; CIBER
   - Centro de Investigacion Biomedica en Red; CIBEROBN; University of
   Navarra
RP Martinez-Gonzalez, MA (corresponding author), Univ Navarra, Dept Prevent Med & Publ Hlth, C Irunlarrea 1, Pamplona 31008, Spain.; Martinez-Gonzalez, MA (corresponding author), Inst Hlth Carlos III, Biomed Res Ctr Network Obes & Nutr CIBERobn, Physiopathol Obes & Nutr, Madrid, Spain.
EM mamartinez@unav.es
RI Sanchez-Villegas, Almudena/T-6733-2019; Martinez-Gonzalez,
   Miguel/AAE-7669-2019; Abad-Gurumeta, Alfredo/M-2337-2019;
   Lahortiga-Ramos, Francisca/H-9363-2017; BES-RASTROLLO,
   MAIRA/A-1329-2009; Perez-Cornago, Aurora/C-1097-2016; Molero,
   Patricio/K-8834-2013
OI Gea, Alfredo/0000-0002-2229-4690; Martinez-Gonzalez, Miguel
   A./0000-0002-3917-9808; Lahortiga-Ramos, Francisca/0000-0001-7624-6902;
   BES-RASTROLLO, MAIRA/0000-0002-9139-4206; Sanchez Villegas,
   Almudena/0000-0001-7733-9238; Perez-Cornago, Aurora/0000-0002-5652-356X;
   Molero, Patricio/0000-0002-9287-9635
FU Spanish Ministry of Health; European Regional Development Fund (FEDER)
   [PI01/0619, PI030678, PI040233, PI042241, PI050976, PI070240, PI070312,
   PI081943, PI080819, PI1002658, PI1002293, RD06/0045, 2010/087, G03/140];
   Navarra Regional Government [45/2011, 122/2014]; University of Navarra
FX This study was supported by the Spanish Ministry of Health and European
   Regional Development Fund (FEDER; grant numbers PI01/0619, PI030678,
   PI040233, PI042241, PI050976, PI070240, PI070312, PI081943, PI080819,
   PI1002658, PI1002293, RD06/0045, 2010/087 and G03/140), the Navarra
   Regional Government (grant numbers 45/2011 and 122/2014), and the
   University of Navarra. The funders had no role in the design, analysis
   or writing of this article.
CR [Anonymous], BIOMED RES INT
   Baudrand R, 2014, CLIN ENDOCRINOL, V80, P677, DOI 10.1111/cen.12225
   Belmaker RH, 2008, NEW ENGL J MED, V358, P55, DOI [10.1056/NEJMra073096, 10.1038/nrdp.2016.65]
   de la Fuente-Arrillaga C, 2010, PUBLIC HEALTH NUTR, V13, P1364, DOI 10.1017/S1368980009993065
   Dixon LB, 2007, J NUTR, V137, P2443, DOI 10.1093/jn/137.11.2443
   Doménech M, 2014, HYPERTENSION, V64, P69, DOI 10.1161/HYPERTENSIONAHA.113.03353
   Fung TT, 2010, AM J CLIN NUTR, V92, P1429, DOI 10.3945/ajcn.2010.29242
   Gea A, 2014, BRIT J NUTR, V111, P1871, DOI 10.1017/S0007114513004376
   Guenther ALB, 2009, HYPERTENSION, V53, P6, DOI 10.1161/HYPERTENSIONAHA.108.116665
   Hamer M, 2012, J CLIN ENDOCR METAB, V97, pE29, DOI 10.1210/jc.2011-2132
   Herbert J, 2013, PSYCHOL MED, V43, P449, DOI 10.1017/S0033291712000955
   Jacka FN, 2013, BRIT J NUTR, V109, P2059, DOI 10.1017/S0007114512004102
   Jacobs DR, 2009, AM J CLIN NUTR, V89, pS1543, DOI 10.3945/ajcn.2009.26736B
   Logan AC, 2014, J PHYSIOL ANTHROPOL, V33, DOI 10.1186/1880-6805-33-22
   Martínez-Gonázlez MA, 2016, P NUTR SOC, V75, P139, DOI 10.1017/S0029665116000045
   Martínez-González MA, 2005, PUBLIC HEALTH NUTR, V8, P920, DOI 10.1079/PHN2005745
   Mellen PB, 2008, ARCH INTERN MED, V168, P308, DOI 10.1001/archinternmed.2007.119
   Meng L, 2012, J HYPERTENS, V30, P842, DOI 10.1097/HJH.0b013e32835080b7
   Miller PE, 2013, AM J CLIN NUTR, V98, P794, DOI 10.3945/ajcn.113.063602
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Payne ME, 2012, J ACAD NUTR DIET, V112, P2022, DOI 10.1016/j.jand.2012.08.026
   Perez-Cornago A, 2015, NUTR NEUROSCI, V18, P137, DOI 10.1179/1476830514Y.0000000116
   Perez-Cornago A, 2014, CLIN NUTR, V33, P1061, DOI 10.1016/j.clnu.2013.11.011
   Perez-Cornago A, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-36
   Rothman KJ, 2008, MODERN EPIDEMIOLOGY
   Salehi-Abargouei A, 2013, NUTRITION, V29, P611, DOI 10.1016/j.nut.2012.12.018
   Sanchez-Villegas A, 2015, BMC MED, V13, DOI 10.1186/s12916-015-0428-y
   Sánchez-Villegas A, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-208
   Sanchez-Villegas A, 2013, BMC MED, V11, DOI [10.1186/1741-7015-11-3, 10.1186/1741-7015-11-208]
   Sanchez-Villegas A, 2008, BMC PSYCHIATRY, V8, DOI 10.1186/1471-244X-8-43
   Sánchez-Villegas A, 2009, ARCH GEN PSYCHIAT, V66, P1090, DOI 10.1001/archgenpsychiatry.2009.129
   Sanhueza C, 2013, J HUM NUTR DIET, V26, P56, DOI 10.1111/j.1365-277X.2012.01283.x
   Torres SJ, 2012, NUTRITION, V28, P896, DOI 10.1016/j.nut.2011.11.029
   Tryon MS, 2015, J CLIN ENDOCR METAB, V100, P2239, DOI 10.1210/jc.2014-4353
   Whiteford HA, 2013, LANCET, V382, P1575, DOI 10.1016/S0140-6736(13)61611-6
   Yannoutsos A, 2014, J HYPERTENS, V32, P216, DOI 10.1097/HJH.0000000000000021
NR 36
TC 45
Z9 47
U1 0
U2 4
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 1368-9800
EI 1475-2727
J9 PUBLIC HEALTH NUTR
JI Public Health Nutr.
PD SEP
PY 2017
VL 20
IS 13
BP 2383
EP 2392
DI 10.1017/S1368980016001531
PG 10
WC Public, Environmental & Occupational Health; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Nutrition & Dietetics
GA FN5EN
UT WOS:000416029500013
PM 27335121
OA Green Submitted, Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Warmbrunn, MV
   Koopen, AM
   De Clercq, NC
   De Groot, PF
   Kootte, RS
   Bouter, KEC
   Ter Horst, KW
   Hartstra, AV
   Serlie, MJ
   Ackermans, MT
   Soeters, MR
   Van Raalte, DH
   Davids, M
   Nieuwdorp, M
   Groen, AK
AF Warmbrunn, Moritz, V
   Koopen, Annefleur M.
   de Clercq, Nicolien C.
   de Groot, Pieter F.
   Kootte, Ruud S.
   Bouter, Kristien E. C.
   ter Horst, Kasper W.
   Hartstra, Annick, V
   Serlie, Mireille J.
   Ackermans, Mariette T.
   Soeters, Maarten R.
   van Raalte, Daniel H.
   Davids, Mark
   Nieuwdorp, Max
   Groen, Albert K.
TI Metabolite Profile of Treatment-Naive Metabolic Syndrome Subjects in
   Relation to Cardiovascular Disease Risk
SO METABOLITES
LA English
DT Article
DE metabolic syndrome; metabolomics; cardiovascular disease; lipolysis;
   phospholipids
ID INSULIN-RESISTANCE; GLUCOSE; ACYLCARNITINES; OBESITY;
   PHOSPHATIDYLCHOLINE; INDIVIDUALS; MICROBIOTA; STRESS
AB Metabolic syndrome (MetSyn) is an important risk factor for type 2 diabetes and cardiovascular diseases (CVD). This study aimed to find distinct plasma metabolite profiles between insulin-resistant and non-insulin resistant subjects with MetSyn and evaluate if MetSyn metabolite profiles are related to CVD risk and lipid fluxes. In a cross-sectional study, untargeted metabolomics of treatment-naive males with MetSyn (n = 132) were analyzed together with clinical parameters. In a subset of MetSyn participants, CVD risk was calculated using the Framingham score (n = 111), and lipolysis (n = 39) was measured by a two-step hyperinsulinemic euglycemic clamp using [1,1,2,3,3-(2)H5] glycerol to calculate lipolysis suppression rates. Peripheral insulin resistance was related to fatty acid metabolism and glycerolphosphorylcholine. Interestingly, although insulin resistance is considered to be a risk factor for CVD, we observed that there was little correspondence between metabolites associated with insulin resistance and metabolites associated with CVD risk. The latter mainly belonged to the androgenic steroid, fatty acid, phosphatidylethanolamine, and phophatidylcholine pathways. These data provide new insights into metabolic changes in mild MetSyn pathophysiology and MetSyn CVD risk related to lipid metabolism. Prospective studies may focus on the pathophysiological role of the here-identified biomarkers.
C1 [Warmbrunn, Moritz, V; Koopen, Annefleur M.; de Clercq, Nicolien C.; de Groot, Pieter F.; Kootte, Ruud S.; Bouter, Kristien E. C.; Hartstra, Annick, V; Davids, Mark; Nieuwdorp, Max; Groen, Albert K.] Amsterdam Univ Med Ctr, Dept Internal & Vasc Med, Locat AMC, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
   [ter Horst, Kasper W.; Serlie, Mireille J.; Ackermans, Mariette T.; Soeters, Maarten R.] Univ Amsterdam, Dept Endocrinol & Metab, Amsterdam UMC, Locat AMC, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
   [van Raalte, Daniel H.] Vrije Univ Amsterdam Med Ctr, Diabet Ctr, Dept Internal Med, Amsterdam UMC,Locat VUMC, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands.
   [van Raalte, Daniel H.] Vrije Univ Amsterdam, Amsterdam Cardiovasc Sci, Amsterdam UMC, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands.
   [Nieuwdorp, Max] Univ Gothenburg, Wallenberg Lab, Bruna Straket 16, SE-41345 Gothenburg, Sweden.
C3 University of Amsterdam; Vrije Universiteit Amsterdam; VU UNIVERSITY
   MEDICAL CENTER; Vrije Universiteit Amsterdam; University of Gothenburg
RP Warmbrunn, MV; Groen, AK (corresponding author), Amsterdam Univ Med Ctr, Dept Internal & Vasc Med, Locat AMC, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
EM m.v.warmbrunn@amsterdamumc.nl; a.m.koopen@amsterdamumc.nl;
   n.c.declercq@amsterdamumc.nl; p.f.degroot@amsterdamumc.nl;
   r.s.kootte@amsterdamumc.nl; k.e.bouter@amsterdamumc.nl;
   k.w.terhorst@amsterdamumc.n1; a.v.hartstra@amsterdamumc.nl;
   mj.serlie@amsterdamumc.nl; m.t.ackermans@amsterdamumc.nl;
   m.r.soeters@amsterdamumc.nl; d.vanraalte@amsterdamumc.nl;
   m.davids@amsterdamumc.nl; m.nieuwdorp@amsterdamumc.nl;
   a.k.groen@amsterdamumc.nl
OI van Raalte, Daniel/0000-0003-2894-6124; de Clercq,
   Nicolien/0000-0002-9924-7171; Davids, Mark/0000-0003-3081-9124;
   Warmbrunn, Moritz Valerian/0000-0003-3548-6728
FU CVON In Control II [2018.27]; ZONMW VIDI grant 2013 [016.146.327]
FX M.V.W. is supported by CVON In Control II (grant number 2018.27). M.N.
   is supported by a ZONMW VIDI grant 2013 (016.146.327).
CR Aguer C, 2015, FASEB J, V29, P336, DOI 10.1096/fj.14-255901
   Apovian CM, 2016, AM J MANAG CARE, V22
   Arendt BM, 2013, APPL PHYSIOL NUTR ME, V38, P334, DOI 10.1139/apnm-2012-0261
   Boden G, 2011, CURR OPIN ENDOCRINOL, V18, P139, DOI 10.1097/MED.0b013e3283444b09
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   D'Agostino RB, 2008, CIRCULATION, V117, P743, DOI 10.1161/CIRCULATIONAHA.107.699579
   DEFRONZO RA, 1979, AM J PHYSIOL, V237, pE214
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Ference BA, 2017, EUR HEART J, V38, P2459, DOI 10.1093/eurheartj/ehx144
   FINEGOOD DT, 1987, DIABETES, V36, P914, DOI 10.2337/diabetes.36.8.914
   Ford ES, 2008, DIABETES CARE, V31, P1898, DOI 10.2337/dc08-0423
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Gao CL, 2010, MOL CELL ENDOCRINOL, V320, P25, DOI 10.1016/j.mce.2010.01.039
   Guasch-Ferré M, 2016, DIABETES CARE, V39, P833, DOI 10.2337/dc15-2251
   Hamaguchi M, 2005, ANN INTERN MED, V143, P722, DOI 10.7326/0003-4819-143-10-200511150-00009
   Hartstra AV, 2020, OBES SCI PRACT, V6, P340, DOI 10.1002/osp4.402
   Hurrle S, 2017, BIOMED J, V40, P257, DOI 10.1016/j.bj.2017.06.007
   Ke CF, 2018, METABOLOMICS, V14, DOI 10.1007/s11306-018-1408-y
   Koh A, 2018, CELL, V175, P947, DOI 10.1016/j.cell.2018.09.055
   Koopen AM, 2020, NUTRIENTS, V12, DOI 10.3390/nu12082308
   Kurella M, 2005, J AM SOC NEPHROL, V16, P2134, DOI 10.1681/ASN.2005010106
   Larsen LN, 1997, LIPIDS, V32, P707, DOI 10.1007/s11745-997-0090-4
   Meikle PJ, 2017, NAT REV ENDOCRINOL, V13, P79, DOI 10.1038/nrendo.2016.169
   Meikle PJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0074341
   Mihalik SJ, 2010, OBESITY, V18, P1695, DOI 10.1038/oby.2009.510
   Muoio DM, 2012, CELL METAB, V15, P595, DOI 10.1016/j.cmet.2012.04.010
   Nemet I, 2020, CELL, V180, P862, DOI 10.1016/j.cell.2020.02.016
   Oh DY, 2010, CELL, V142, P687, DOI 10.1016/j.cell.2010.07.041
   Ormazabal V, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0762-4
   Pyle L, 2016, AM J PHYSIOL-ENDOC M, V310, pE323, DOI 10.1152/ajpendo.00368.2015
   Roberts CK, 2013, COMPR PHYSIOL, V3, P1, DOI 10.1002/cphy.c110062
   Schooneman MG, 2013, DIABETES, V62, P1, DOI 10.2337/db12-0466
   STEELE R, 1959, ANN NY ACAD SCI, V82, P420, DOI 10.1111/j.1749-6632.1959.tb44923.x
   Strifler G, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0166682
   Surowiec I, 2019, METABOLOMICS, V15, DOI 10.1007/s11306-019-1484-7
   Tam CS, 2012, DIABETES CARE, V35, P1605, DOI 10.2337/dc11-2339
   ter Horst KW, 2015, INT J OBESITY, V39, P1703, DOI 10.1038/ijo.2015.125
   Tuboly E, 2019, MOL CELL BIOCHEM, V460, P195, DOI 10.1007/s11010-019-03580-1
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wang ZN, 2011, NATURE, V472, P57, DOI 10.1038/nature09922
   Warmbrunn MV, 2020, EXPERT REV ENDOCRINO, V15, P13, DOI 10.1080/17446651.2020.1720511
   Weir JM, 2013, J LIPID RES, V54, P2898, DOI 10.1194/jlr.P035808
   Whitlock G, 2009, LANCET, V373, P1083, DOI 10.1016/S0140-6736(09)60318-4
   Würtz P, 2015, CIRCULATION, V131, P774, DOI 10.1161/CIRCULATIONAHA.114.013116
NR 44
TC 8
Z9 8
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD APR
PY 2021
VL 11
IS 4
AR 236
DI 10.3390/metabo11040236
PG 11
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA RR7MO
UT WOS:000643277900001
PM 33924347
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Usal, M
   Regnault, C
   Veyrenc, S
   Couturier, K
   Batandier, C
   Bulteau, AL
   Lejon, D
   Combourieu, B
   Lafond, T
   Raveton, M
   Reynaud, S
AF Usal, Marie
   Regnault, Christophe
   Veyrenc, Sylvie
   Couturier, Karine
   Batandier, Cecile
   Bulteau, Anne-Laure
   Lejon, David
   Combourieu, Bruno
   Lafond, Thomas
   Raveton, Muriel
   Reynaud, Stephane
TI Concomitant exposure to benzo[a]pyrene and triclosan at environmentally
   relevant concentrations induces metabolic syndrome with
   multigenerational consequences in Silurana (Xenopus) tropicalis
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE Endocrine disruptors; Metabolic syndrome; Amphibian populatiot ectine;
   Transgenerational; Silurana (Xeriopus`) tropicalis
ID NONALCOHOLIC FATTY LIVER; BISPHENOL-A EXPOSURE; ENDOCRINE-DISRUPTING
   COMPOUNDS; HEPATIC STEATOSIS; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   MITOCHONDRIAL DYSFUNCTION; AROMATIC-HYDROCARBONS; REPRODUCTIVE-BIOLOGY;
   LIPID-METABOLISM
AB Numerous studies suggest that amphibians are highly sensitive to endocrine disruptors (ED) but their precise role in population decline remains unknown. This study shows that frogs exposed to a mixture of ED throughout their life cycle, at environmentally relevant concentrations, developed an unexpected metabolic syndrome. female Silurana (Xenopus) tropicalis exposed to a mixture of benzo[alpyrene and triclosan (50 ng"L each) from the tadpole stage developed liver steatosis and transcriptomic signature associated with glucose intolerance syndrome, and pancreatic insulin hyper secretion typical of pre -diabetes. These metabolic disorders were associated with delayed! metamorphosis and developmental mortality in their progeny, both of which have been linked to reduced adult recruitment and reproductive success. Indeed, Fl females were smaller and lighter and presented reduced reproductive capacities, demonstrating a reduced fitness of ED -exposed Xenopus. Our results confirm that amphibians are highly sensitive to ED even at concentrations considered to be safe for other animals. This study demonstrates that ED might be considered as direct contributing factors to amphibian population decline, due to their disruption of energetic metabolism. C 2019 Elsevier 13.V. All rights reserved.
C1 [Usal, Marie; Regnault, Christophe; Veyrenc, Sylvie; Raveton, Muriel; Reynaud, Stephane] Univ Savoie Mt Blanc, Univ Grenoble Alpes, CNRS, LECA, F-38000 Grenoble, France.
   [Couturier, Karine; Batandier, Cecile] Univ Grenoble Alpes, INSERM, LBFA, F-38000 Grenoble, France.
   [Bulteau, Anne-Laure] Univ Lyon 1, Ecole Normale Super Lyon, CNRS, Inst Genom Fonct Lyon,UMR5242, F-69000 Lyon, France.
   [Lejon, David; Combourieu, Bruno] Rovaltain Res Co, F-26300 Alixan, France.
   [Lafond, Thomas] Univ Rennes 1, CNRS, Ctr Ressources Biol Xenopes, UMS 3387, Rennes, France.
C3 Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA);
   Centre National de la Recherche Scientifique (CNRS); Universite Savoie
   Mont Blanc; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Communaute Universite Grenoble Alpes; Universite Grenoble
   Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); CNRS -
   National Institute for Biology (INSB); CHU Lyon; Ecole Normale
   Superieure de Lyon (ENS de LYON); Universite Claude Bernard Lyon 1;
   Universite de Rennes; Centre National de la Recherche Scientifique
   (CNRS)
RP Reynaud, S (corresponding author), Univ Savoie Mt Blanc, Univ Grenoble Alpes, CNRS, LECA, F-38000 Grenoble, France.
EM sylvie.veyrenc@univ-grenoble-alpes.fr;
   karine.couturier@univ-grenoble-alpes.fr;
   cecile.batandier@univ-grenoble-alpes.fr; anne-laure.bulteau@ens-lyon.fr;
   dlejon@rovaltainresearch.com; Bruno.combourieu@rovaltainresearch.com;
   thomas.lafond@univ-rennes1.fr; muriel.raveton@univ-grenoble-alpes.fr;
   stephane.reynaud@univ-grenoble-alpes.fr
RI bulteau, anne-laure/AAN-4004-2020; Raveton, Muriel/K-1403-2013; Reynaud,
   Stephane/H-5493-2013
OI veyrenc, sylvie/0000-0003-2894-3820; Reynaud,
   Stephane/0000-0003-0248-0602
FU ComUE Universite Grenoble-Alpes IRS IDEX; CNRS-INSU EC2CO program;
   Federative Structure Environmental and Systems Biology (BEeSy) of the
   Grenoble-Alpes University; French Ministry of Higher Education and
   Research; Region Auvergne-Rhone-Alpes
FX This work was funded by the ComUE Universite Grenoble-Alpes IRS IDEX
   Grant, by the CNRS-INSU EC2CO program and by the Federative Structure
   Environmental and Systems Biology (BEeSy) of the Grenoble-Alpes
   University. Marie Usal was funded by the Region Auvergne-Rhone-Alpes.
   Christophe Regnault received funding from the French Ministry of Higher
   Education and Research. We thank Kim Barrett (Version Originale) for the
   English review of the manuscript.
CR Alonso-Magdalena P, 2010, ENVIRON HEALTH PERSP, V118, P1243, DOI 10.1289/ehp.1001993
   Barber LB, 2015, SCI TOTAL ENVIRON, V517, P195, DOI 10.1016/j.scitotenv.2015.02.035
   Bechmann LP, 2012, J HEPATOL, V56, P952, DOI 10.1016/j.jhep.2011.08.025
   Bedossa P, 2016, DIGEST DIS SCI, V61, P1348, DOI 10.1007/s10620-016-4062-0
   Blair BD, 2013, CHEMOSPHERE, V93, P2116, DOI 10.1016/j.chemosphere.2013.07.057
   Blaustein AR, 2007, BIOSCIENCE, V57, P437, DOI 10.1641/B570517
   Bolger AM, 2014, BIOINFORMATICS, V30, P2114, DOI 10.1093/bioinformatics/btu170
   Brooks S, 1997, REV FISH BIOL FISHER, V7, P387, DOI 10.1023/A:1018400130692
   Browne RK, 2007, ILAR J, V48, P214, DOI 10.1093/ilar.48.3.214
   Bulteau AL, 2003, BIOCHEMISTRY-US, V42, P14846, DOI 10.1021/bi0353979
   Bulteau AL, 2002, ARCH BIOCHEM BIOPHYS, V397, P298, DOI 10.1006/abbi.2001.2663
   Casals-Casas C, 2011, ANNU REV PHYSIOL, V73, P135, DOI 10.1146/annurev-physiol-012110-142200
   Chevalier N, 2015, DIABETES METAB, V41, P107, DOI 10.1016/j.diabet.2014.09.005
   Chevalier N, 2015, REV ENDOCR METAB DIS, V16, P299, DOI 10.1007/s11154-016-9333-8
   Chevalier N, 2016, PRESSE MED, V45, P88, DOI 10.1016/j.lpm.2015.08.008
   Crump D, 2002, ENVIRON HEALTH PERSP, V110, P1199, DOI 10.1289/ehp.021101199
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   Day CP, 2006, GASTROENTEROLOGY, V130, P207, DOI 10.1053/j.gastro.2005.11.017
   Duarte-Guterman P, 2014, GEN COMP ENDOCR, V203, P69, DOI 10.1016/j.ygcen.2014.03.015
   Dziminski MA, 2006, J EVOLUTION BIOL, V19, P144, DOI 10.1111/j.1420-9101.2005.00978.x
   Fedorenkova A, 2012, ENVIRON TOXICOL CHEM, V31, P1416, DOI 10.1002/etc.1831
   Felder TK, 2007, INT J OBESITY, V31, P1099, DOI 10.1038/sj.ijo.0803505
   Ferré P, 2010, DIABETES OBES METAB, V12, P83, DOI 10.1111/j.1463-1326.2010.01275.x
   Galloway J. M., 2005, USGS NUMBERED SERIES
   Garait B, 2005, FREE RADICAL BIO MED, V39, P1249, DOI 10.1016/j.freeradbiomed.2005.06.026
   Gardner M, 2012, SCI TOTAL ENVIRON, V437, P363, DOI 10.1016/j.scitotenv.2012.07.086
   Godoy AA, 2017, CRIT REV ENV SCI TEC, V47, P1453, DOI 10.1080/10643389.2017.1370991
   Grün F, 2006, MOL ENDOCRINOL, V20, P2141, DOI 10.1210/me.2005-0367
   Guan YJ, 2016, COMP BIOCHEM PHYS C, V179, P144, DOI 10.1016/j.cbpc.2015.10.006
   Han XQ, 2016, BIOSCI BIOTECH BIOCH, V80, P735, DOI 10.1080/09168451.2015.1123608
   Hayes T, 2002, NATURE, V419, P895, DOI 10.1038/419895a
   Hayes TB, 2010, J EXP BIOL, V213, P921, DOI 10.1242/jeb.040865
   Hayes TB, 2006, ENVIRON HEALTH PERSP, V114, P40, DOI 10.1289/ehp.8051
   Hayes TB, 2011, J STEROID BIOCHEM, V127, P64, DOI 10.1016/j.jsbmb.2011.03.015
   Hua MC, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0182277
   Huang DW, 2009, NUCLEIC ACIDS RES, V37, P1, DOI 10.1093/nar/gkn923
   Jiang Y, 2014, TOXICOL LETT, V228, P85, DOI 10.1016/j.toxlet.2014.04.013
   Kaplan M., 2009, NAT NEWS
   Kashiwagi A, 2008, J HEALTH SCI, V54, P273, DOI 10.1248/jhs.54.273
   Kasuga M, 2006, J CLIN INVEST, V116, P1756, DOI 10.1172/JCI29189
   Kloas W, 2009, ANN NY ACAD SCI, V1163, P187, DOI 10.1111/j.1749-6632.2009.04453.x
   Koliaki C, 2015, CELL METAB, V21, P739, DOI 10.1016/j.cmet.2015.04.004
   KURAMOTO M, 1978, EVOLUTION, V32, P287, DOI 10.1111/j.1558-5646.1978.tb00644.x
   Langlois VS, 2010, GEN COMP ENDOCR, V166, P417, DOI 10.1016/j.ygcen.2009.11.004
   Levy CW, 1999, NATURE, V398, P383, DOI 10.1038/18803
   Lindström A, 2002, ENVIRON SCI TECHNOL, V36, P2322, DOI 10.1021/es0114254
   Liu XL, 2016, J DIGEST DIS, V17, P708, DOI 10.1111/1751-2980.12408
   Lockman KA, 2012, LIVER INT, V32, P1079, DOI 10.1111/j.1478-3231.2012.02775.x
   Lorenz C, 2011, TOXICOL SCI, V123, P94, DOI 10.1093/toxsci/kfr159
   Mansego ML, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031853
   Mastrocola R, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0119587
   McArthur J Vaun, 2012, Handb Exp Pharmacol, P135, DOI 10.1007/978-3-642-28951-4_9
   McAvoy DC, 2002, ENVIRON TOXICOL CHEM, V21, P1323, DOI 10.1897/1551-5028(2002)021<1323:MOTIWT>2.0.CO;2
   Medic-Stojanoska M., 2019, END ABSTR, V63
   Miksztowicz V, 2012, DIABETES-METAB RES, V28, P535, DOI 10.1002/dmrr.2312
   Moretro T, 2011, INT J FOOD MICROBIOL, V146, P157, DOI 10.1016/j.ijfoodmicro.2011.02.017
   Mosconi G, 2002, GEN COMP ENDOCR, V126, P125, DOI 10.1006/gcen.2002.7781
   Moyer BJ, 2016, TOXICOL APPL PHARM, V300, P13, DOI 10.1016/j.taap.2016.03.011
   Mukai T, 2017, FEBS OPEN BIO, V7, P1009, DOI 10.1002/2211-5463.12240
   Naik A, 2013, GENOMICS, V102, P84, DOI 10.1016/j.ygeno.2013.03.007
   Neuschäfer-Rube F, 2015, TOXICOLOGY, V337, P1, DOI 10.1016/j.tox.2015.08.007
   Olivares-Rubio HF, 2015, ECOTOXICOLOGY, V24, P664, DOI 10.1007/s10646-014-1414-4
   Otoda T, 2013, DIABETES, V62, P811, DOI 10.2337/db11-1652
   Petersen AM, 2007, J EXP BIOL, V210, P1786, DOI 10.1242/jeb.004499
   Petersen KF, 2007, P NATL ACAD SCI USA, V104, P12587, DOI 10.1073/pnas.0705408104
   Pfaffl MW, 2001, NUCLEIC ACIDS RES, V29, DOI 10.1093/nar/29.9.e45
   Piccoli A, 2002, FARMACO, V57, P369, DOI 10.1016/S0014-827X(02)01225-9
   Ramakrishnan G, 2012, DIABETES VASC DIS RE, V9, P196, DOI 10.1177/1479164111430243
   Regnault C, 2018, P NATL ACAD SCI USA, V115, pE4416, DOI 10.1073/pnas.1721267115
   Regnault C, 2016, CHEMOSPHERE, V155, P519, DOI 10.1016/j.chemosphere.2016.04.047
   Regnault C, 2014, BMC GENOMICS, V15, DOI 10.1186/1471-2164-15-666
   Relyea RA, 2009, OECOLOGIA, V159, P363, DOI [10.1007/s00442-008-1141-8, 10.1007/s00442-008-1213-9]
   Roelants K, 2007, P NATL ACAD SCI USA, V104, P887, DOI 10.1073/pnas.0608378104
   Rousset S, 2004, DIABETES, V53, pS130, DOI 10.2337/diabetes.53.2007.S130
   Rumrill CT, 2018, ENVIRON TOXICOL CHEM, V37, P2660, DOI 10.1002/etc.4228
   Saeed AI, 2003, BIOTECHNIQUES, V34, P374, DOI 10.2144/03342mt01
   Santangeli S, 2018, SCI TOTAL ENVIRON, V636, P641, DOI 10.1016/j.scitotenv.2018.04.291
   Shi HH, 2014, TOXICOL IND HEALTH, V30, P297, DOI 10.1177/0748233712457440
   Showell C, 2009, COLD SPRING HARB PRO, V2009
   SMITH DC, 1987, ECOLOGY, V68, P344, DOI 10.2307/1939265
   Srere P.A., 1969, Methods in Enzymology, V13, P3, DOI DOI 10.1016/0076-6879(69)13005-0
   Srogi K, 2007, ENVIRON CHEM LETT, V5, P169, DOI 10.1007/s10311-007-0095-0
   Susiarjo M, 2015, ENDOCRINOLOGY, V156, P2049, DOI 10.1210/en.2014-2027
   Takahashi Y, 2014, WORLD J GASTROENTERO, V20, P15539, DOI 10.3748/wjg.v20.i42.15539
   Teubner D, 2015, ENVIRON SCI POLLUT R, V22, P1620, DOI 10.1007/s11356-014-3008-3
   Todd BD, 2011, ENVIRON TOXICOL CHEM, V30, P2277, DOI 10.1002/etc.617
   Trapido M, 1996, HYDROBIOLOGIA, V338, P185, DOI 10.1007/BF00031723
   Trapnell C, 2012, NAT PROTOC, V7, P562, DOI 10.1038/nprot.2012.016
   Trapnell C, 2009, BIOINFORMATICS, V25, P1105, DOI 10.1093/bioinformatics/btp120
   Ucar F, 2013, REDOX REP, V18, P127, DOI 10.1179/1351000213Y.0000000050
   United States Government, 2010, END DISR SCREEN PROG
   Urbatzka R, 2006, GEN COMP ENDOCR, V146, P119, DOI 10.1016/j.ygcen.2005.10.005
   Urbatzka R, 2007, COMP BIOCHEM PHYS C, V144, P310, DOI 10.1016/j.cbpc.2006.10.008
   VanSaun MN, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0073054
   Veldhoen N, 2006, AQUAT TOXICOL, V80, P217, DOI 10.1016/j.aquatox.2006.08.010
   Vial G, 2011, J HEPATOL, V54, P348, DOI 10.1016/j.jhep.2010.06.044
   Wang Q, 2009, HEPATOLOGY, V49, P1166, DOI 10.1002/hep.22774
   Weir A, 2010, ACS SYM SER, V1048, P421
   Whitacre D. M, 2010, REV ENV CONTAMINATIO, V206
   Yamaguchi K, 2007, HEPATOLOGY, V45, P1366, DOI 10.1002/hep.21655
   Yuan Y, 2011, AM J PHYSIOL-RENAL, V301, pF236, DOI 10.1152/ajprenal.00646.2010
   Zhang WY, 2016, TOXICOL LETT, V258, P192, DOI 10.1016/j.toxlet.2016.07.003
NR 102
TC 13
Z9 14
U1 0
U2 46
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0048-9697
EI 1879-1026
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD NOV 1
PY 2019
VL 689
BP 149
EP 159
DI 10.1016/j.scitotenv.2019.06.386
PG 11
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA IS8DP
UT WOS:000482379400015
PM 31271984
OA Green Accepted, Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Vecoli, C
   Caselli, C
   Modena, M
   Todiere, G
   Poddighe, R
   Valente, S
   Bandini, F
   Natali, A
   Ghiadoni, L
   Clerico, A
   Prontera, C
   Vittorini, S
   Botto, N
   Emdin, M
   Neglia, D
AF Vecoli, Cecilia
   Caselli, Chiara
   Modena, Martina
   Todiere, Giancarlo
   Poddighe, Rosa
   Valente, Serafina
   Bandini, Fabrizio
   Natali, Andrea
   Ghiadoni, Lorenzo
   Clerico, Aldo
   Prontera, Concetta
   Vittorini, Simona
   Botto, Nicoletta
   Emdin, Michele
   Neglia, Danilo
TI Low HDL cholesterol and the eNOS Glu298Asp polymorphism are associated
   with inducible myocardial ischemia in patients with suspected stable
   coronary artery disease
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Article
DE Endothelial dysfunction; Endothelial nitric oxide synthase; eNOS; Single
   nucleotide polymorphism; Obstructive coronary artery disease; Inducible
   myocardial ischemia
ID OXIDE SYNTHASE GENE; NITRIC-OXIDE; INSULIN-RESISTANCE; HEART-DISEASE;
   GLOBAL BURDEN; RISK; OBESITY; MICROCIRCULATION; PATHOPHYSIOLOGY;
   MANAGEMENT
AB BackgroundThe endothelial nitric oxide synthase (eNOS) gene deficiency is known to cause impaired coronary vasodilating capability in animal models. In the general clinical population, the eNOS gene polymorphisms, able to affect eNOS activity, were associated with cardiometabolic risk features and prevalence of coronary artery disease (CAD).AimTo investigate the association of eNOS Glu298Asp gene polymorphism, cardiometabolic profile, obstructive CAD and inducible myocardial ischemia in patients with suspected stable CAD.MethodsA total of 506 patients (314 males; mean age 62 +/- 9 years) referred for suspected CAD was enrolled. Among these, 325 patients underwent stress ECG or cardiac imaging to assess the presence of inducible myocardial ischemia and 436 patients underwent non-invasive computerized tomography or invasive coronary angiography to assess the presence of obstructive CAD. Clinical characteristics and blood samples were collected for each patient.ResultsIn the whole population, 49.6% of patients were homozygous for the Glu298 genotype (Glu/Glu), 40.9% heterozygotes (Glu/Asp) and 9.5% homozygous for the 298Asp genotype (Asp/Asp). Obstructive CAD was documented in 178/436 (40.8%) patients undergoing coronary angiography while myocardial ischemia in 160/325 (49.2%) patients undergoing stress testing. Patients with eNOS Asp genotype (Glu/Asp + Asp/Asp) had no significant differences in clinical risk factors and in circulating markers. Independent predictors of obstructive CAD were age, gender, obesity, and low HDL-C. Independent predictors of myocardial ischemia were gender, obesity, low HDL-C and Asp genotype. In the subpopulation in which both stress tests and coronary angiography were performed, the Asp genotype remained associated with increased myocardial ischemia risk after adjustment for obstructive CAD.ConclusionIn this population, low-HDL cholesterol was the only cardiometabolic risk determinant of obstructive CAD. The eNOS Glu298Asp gene polymorphism was significantly associated with inducible myocardial ischemia independently of other risk factors and presence of obstructive CAD.
C1 [Vecoli, Cecilia; Caselli, Chiara] Inst Clin Physiol, CNR, Via G Moruzzi 1, Pisa, Italy.
   [Vecoli, Cecilia; Caselli, Chiara; Todiere, Giancarlo; Clerico, Aldo; Prontera, Concetta; Vittorini, Simona; Botto, Nicoletta; Emdin, Michele; Neglia, Danilo] Gabriele Monasterio Fdn, Cardiovasc Dept, Via G Moruzzi 1, Pisa, Italy.
   [Modena, Martina; Emdin, Michele; Neglia, Danilo] St Anna Sch Adv Studies, Pisa, Italy.
   [Poddighe, Rosa] Osped Versilia, Lucca, Italy.
   [Valente, Serafina] Careggi Univ Hosp AOUC, Florence, Italy.
   [Bandini, Fabrizio] Az Sanitaria Firenze, Florence, Italy.
   [Natali, Andrea; Ghiadoni, Lorenzo] Univ Pisa, Dept Clin & Expt Med, Pisa, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto di Fisiologia Clinica
   (IFC-CNR); Scuola Superiore Sant'Anna; Ospedale Versilia; University of
   Florence; Azienda Ospedaliero Universitaria Careggi; University of Pisa
RP Vecoli, C (corresponding author), Inst Clin Physiol, CNR, Via G Moruzzi 1, Pisa, Italy.; Vecoli, C; Neglia, D (corresponding author), Gabriele Monasterio Fdn, Cardiovasc Dept, Via G Moruzzi 1, Pisa, Italy.; Neglia, D (corresponding author), St Anna Sch Adv Studies, Pisa, Italy.
EM cecilia.vecoli@cnr.it; dneglia@ftgm.it
RI Neglia, Danilo/AAR-6384-2020; clerico, aldo/JXN-8816-2024; Emdin,
   Michele/AAC-6465-2022; Modena, Mario/AAF-3997-2019; Vecoli,
   Cecilia/K-8613-2016; Ghiadoni, Lorenzo/AAC-5176-2022; Caselli,
   Chiara/I-7922-2014
OI Ghiadoni, Lorenzo/0000-0002-7399-2720; Caselli,
   Chiara/0000-0001-6705-2460
FU Grant of the "Regional Health Research Program 2009" from the Regione
   Toscana, Italy
FX This study was supported by a Grant of the "Regional Health Research
   Program 2009" from the Regione Toscana, Italy.
CR Alexander Y, 2021, CARDIOVASC RES, V117, P29, DOI 10.1093/cvr/cvaa085
   Alshammary AF, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18041773
   Azab M, 2018, METAB SYNDR RELAT D, V16, P440, DOI 10.1089/met.2017.0152
   Camici PG, 2007, NEW ENGL J MED, V356, P830, DOI 10.1056/NEJMra061889
   Caselli C, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-00020-3
   Catapano AL, 2016, EUR HEART J, V37, P2999, DOI 10.1093/eurheartj/ehw272
   Chang KY, 2003, CORONARY ARTERY DIS, V14, P293, DOI 10.1097/01.mca.0000073080.69657.71
   Chen ZK, 2020, J DIABETES INVEST, V11, P475, DOI 10.1111/jdi.13118
   Cook S, 2004, DIABETES, V53, P2067, DOI 10.2337/diabetes.53.8.2067
   Cortigiani L, 2021, INT J OBESITY, V45, P308, DOI 10.1038/s41366-020-00655-8
   Crea F, 2022, CIRC J, V86, P1319, DOI 10.1253/circj.CJ-21-0848
   De Schutter A, 2016, INT J OBESITY, V40, P1730, DOI 10.1038/ijo.2016.125
   Di Giorgi N, 2021, ATHEROSCLEROSIS, V339, P1, DOI 10.1016/j.atherosclerosis.2021.11.013
   Duplain H, 2001, CIRCULATION, V104, P342, DOI 10.1161/01.CIR.104.3.342
   Fairchild TA, 2001, J BIOL CHEM, V276, P26674, DOI 10.1074/jbc.M103647200
   González-Sánchez JL, 2007, CLIN CHEM, V53, P91, DOI [10.1373/clinchem.2007.075176, 10.1373/clinchem.2006.075176]
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Guembe MJ, 2020, CARDIOVASC DIABETOL, V19, DOI 10.1186/s12933-020-01166-6
   Imamura A, 2008, EUR J ENDOCRINOL, V158, P189, DOI 10.1530/EJE-07-0632
   Isordia-Salas I, 2010, CLIN CHIM ACTA, V411, P553, DOI 10.1016/j.cca.2010.01.013
   Joshi MS, 2007, FASEB J, V21, P2655, DOI 10.1096/fj.06-7088com
   Knuuti J, 2020, EUR HEART J, V41, P407, DOI 10.1093/eurheartj/ehz425
   Kunadian V, 2021, EUROINTERVENTION, V16, DOI 10.4244/EIJY20M07_01
   Luo JQ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0087196
   Mandviwala T, 2016, CURR ATHEROSCLER REP, V18, DOI 10.1007/s11883-016-0575-4
   McDonald DM, 2004, PHARMACOGENETICS, V14, P831, DOI 10.1097/00008571-200412000-00006
   Monti LD, 2003, DIABETES, V52, P1270, DOI 10.2337/diabetes.52.5.1270
   Moran AE, 2014, CIRCULATION, V129, P1493, DOI 10.1161/CIRCULATIONAHA.113.004046
   Padro T, 2020, CARDIOVASC RES, V116, P741, DOI 10.1093/cvr/cvaa003
   PALMER RMJ, 1988, NATURE, V333, P664, DOI 10.1038/333664a0
   Pérez-Méndez O, 2014, CLIN CHIM ACTA, V429, P111, DOI 10.1016/j.cca.2013.12.001
   Persu A, 2002, HUM MOL GENET, V11, P229, DOI 10.1093/hmg/11.3.229
   Pirillo A, 2019, CURR MED CHEM, V26, P1644, DOI 10.2174/0929867325666180530110543
   Poirier P, 2006, CIRCULATION, V113, P898, DOI 10.1161/CIRCULATIONAHA.106.171016
   Poredos P, 2021, ANGIOLOGY, V72, P604, DOI 10.1177/0003319720987752
   Rossi GP, 2003, J AM COLL CARDIOL, V41, P938, DOI 10.1016/S0735-1097(02)03011-5
   Severino P, 2021, J CARDIOVASC DEV DIS, V8, DOI 10.3390/jcdd8090116
   Sorop O, 2017, CARDIOVASC RES, V113, P1035, DOI 10.1093/cvr/cvx093
   Tesauro M, 2000, P NATL ACAD SCI USA, V97, P2832, DOI 10.1073/pnas.97.6.2832
   Vaduganathan M, 2022, J AM COLL CARDIOL, V80, P2361, DOI 10.1016/j.jacc.2022.11.005
   Vecoli C, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0104156
   Vecoli C, 2012, BMC MED GENET, V13, DOI 10.1186/1471-2350-13-92
   von Eckardstein A, 2023, EUR HEART J, V44, P1394, DOI 10.1093/eurheartj/ehac605
   Wang HD, 2016, LANCET, V388, P1459, DOI 10.1016/S0140-6736(16)31012-1
   Yu JH, 2020, GENOMICS, V112, P2452, DOI 10.1016/j.ygeno.2020.01.019
   Zigra AM, 2013, DIS MARKERS, V34, P431, DOI [10.1155/2013/235056, 10.3233/DMA-130987]
NR 46
TC 2
Z9 2
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD MAR 22
PY 2024
VL 24
IS 1
AR 176
DI 10.1186/s12872-024-03846-7
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA LU6Y4
UT WOS:001189365900002
PM 38519897
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Oteri, V
   Galeano, F
   Panebianco, S
   Piticchio, T
   Le Moli, R
   Frittitta, L
   Vella, V
   Baratta, R
   Gullo, D
   Frasca, F
   Tumminia, A
AF Oteri, Vittorio
   Galeano, Francesco
   Panebianco, Stefania
   Piticchio, Tommaso
   Le Moli, Rosario
   Frittitta, Lucia
   Vella, Veronica
   Baratta, Roberto
   Gullo, Damiano
   Frasca, Francesco
   Tumminia, Andrea
TI Influence of Mediterranean Diet on Sexual Function in People with
   Metabolic Syndrome: A Narrative Review
SO NUTRIENTS
LA English
DT Review
DE metabolic syndrome; sexual function; Mediterranean diet; erectile
   dysfunction; libido; infertility; menstrual cycle; oxidative stress;
   obesity; metabolism
ID POLYCYSTIC-OVARY-SYNDROME; URINARY-TRACT SYMPTOMS; WESTERN-STYLE DIET;
   LOW-ENERGY DIET; REPRODUCTIVE FUNCTION; ERECTILE DYSFUNCTION;
   INSULIN-RESISTANCE; UNITED-STATES; SEMEN QUALITY; FATTY-ACIDS
AB Metabolic syndrome (MS), a cluster of cardiometabolic disorders, and sexual dysfunction are two conditions that impact a large proportion of the general population. Although they can occur independently, they are frequently linked and significantly affect people's quality of life. In recent years, research has increasingly focused on the importance of diet, particularly the Mediterranean diet (MD), in modulating sexual function due to its anti-inflammatory, antioxidant, and vasodilatory properties. In this narrative review, we examined the relationship between MS and sexual function in both men and women, with a special emphasis on the MD's therapeutic efficacy in improving sexual dysfunction. In men, MD has been shown to ameliorate erectile dysfunction, as well as several sperm parameters, perhaps leading to improved fertility. On the other hand, adherence to MD has been demonstrated to partially recover several sexual dysfunctions in women, such as those related to their menstrual cycle, menopause, endometriosis, and polycystic ovary syndrome. These favorable effects of MD have been demonstrated in both sexes also among people affected by MS. However, more targeted studies are needed to validate these data for different dietary approaches as well.
C1 [Oteri, Vittorio; Galeano, Francesco; Panebianco, Stefania; Piticchio, Tommaso; Le Moli, Rosario; Frittitta, Lucia; Vella, Veronica; Frasca, Francesco] Univ Catania, Garibaldi Nesima Hosp, Dept Clin & Expt Med, Endocrinol Sect, I-95122 Catania, CT, Italy.
   [Piticchio, Tommaso; Le Moli, Rosario] Univ Kore Enna, Dept Med & Surg, I-94100 Enna, EN, Italy.
   [Frittitta, Lucia] Univ Catania, Garibaldi Nesima Hosp, Diabet & Obes Ctr, I-95122 Catania, CT, Italy.
   [Baratta, Roberto; Gullo, Damiano; Frasca, Francesco; Tumminia, Andrea] Garibaldi Nesima Hosp, Endocrine Unit, I-95122 Catania, CT, Italy.
C3 University of Catania; Presidio Ospedaliero Garibaldi-Nesima; Universita
   Kore di ENNA; Presidio Ospedaliero Garibaldi-Nesima; University of
   Catania; Presidio Ospedaliero Garibaldi-Nesima
RP Frasca, F (corresponding author), Univ Catania, Garibaldi Nesima Hosp, Dept Clin & Expt Med, Endocrinol Sect, I-95122 Catania, CT, Italy.; Frasca, F (corresponding author), Garibaldi Nesima Hosp, Endocrine Unit, I-95122 Catania, CT, Italy.
EM research@droteri.it; francesco.galeano3@gmail.com;
   dottoressa.panebianco@gmail.com; tommaso.piticchio@unikore.it;
   rosario.lemoli@unikore.it; lucia.frittitta@unict.it;
   veronica.vella@unict.it; rob.baratta@gmail.com; gullo.family@alice.it;
   frascafranco@gmail.com; andreatumminia82@gmail.com
RI Vella, Dott.ssa/AAX-5690-2020; Piticchio, Tommaso/AHE-5143-2022;
   frittitta, lucia/J-2334-2012; Tumminia, Andrea/ABM-1770-2022; LEMOLI,
   ROBERTO/AAC-2370-2022; Baratta, Roberto/IQR-8839-2023
OI Baratta, Roberto/0000-0003-0524-4525; Panebianco,
   Stefania/0009-0003-8158-7332; Galeano, Francesco/0009-0004-4104-1105;
   Oteri, Vittorio/0000-0001-5210-8601; FRITTITTA,
   Lucia/0000-0002-7941-5828; LE MOLI, Rosario/0000-0002-1398-9271
FU University of Catania; National Recovery and Resilience Plan - European
   Union [PE00000003, 1550]
FX The article processing charge (APC) was funded by the University of
   Catania. The study was supported by the project entitled "ON
   Foods-Research and innovation network on food and nutrition
   Sustainability, Safety and Security-Working ON Foods" funded under the
   National Recovery and Resilience Plan (NRRP), Mission 4 Component 2
   Investment 1.3-Call for tender No. 341 of 15 March 2022 of Italian
   Ministry of University and Research funded by the European
   Union-NextGenerationEU; Project code PE00000003, Concession Decree No.
   1550 of 11 October 2022 adopted by the Italian Ministry of University
   and Research.
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Ajala O, 2013, AM J CLIN NUTR, V97, P505, DOI 10.3945/ajcn.112.042457
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Ambikairajah A, 2019, MENOPAUSE, V26, P1327, DOI 10.1097/GME.0000000000001403
   Babio N, 2009, PUBLIC HEALTH NUTR, V12, P1607, DOI 10.1017/S1368980009990449
   Bacon CG, 2002, DIABETES CARE, V25, P1458, DOI 10.2337/diacare.25.8.1458
   Bakaloudi DR, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051514
   Bansal TC, 2005, J SEX MED, V2, P96, DOI 10.1111/j.1743-6109.2005.20120.x
   Barbería-Latasa M, 2022, NUTRIENTS, V14, DOI 10.3390/nu14091954
   Barnard ND, 2000, OBSTET GYNECOL, V95, P245, DOI 10.1016/S0029-7844(99)00525-6
   Barrea L, 2023, CURR NUTR REP, V12, P65, DOI 10.1007/s13668-023-00463-2
   Barrea L, 2021, NUTRIENTS, V13, DOI 10.3390/nu13113925
   Barrea L, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102278
   Bauer SR, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.21701
   Bermingham KM, 2024, NAT MED, V30, P1888, DOI 10.1038/s41591-024-02951-6
   Bermingham KM, 2022, EBIOMEDICINE, V85, DOI 10.1016/j.ebiom.2022.104303
   Bil E, 2016, J OBSTET GYNAECOL RE, V42, P837, DOI 10.1111/jog.12985
   Caceres S, 2019, REPROD DOMEST ANIM, V54, P855, DOI 10.1111/rda.13434
   Cano A, 2020, MATURITAS, V139, P90, DOI 10.1016/j.maturitas.2020.07.001
   Castro AI, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101348
   Chen WX, 2021, METABOLITES, V11, DOI 10.3390/metabo11120869
   Cincione IR, 2023, J ENDOCRINOL INVEST, V46, P769, DOI 10.1007/s40618-022-01943-y
   Ciolek A, 2024, NUTRIENTS, V16, DOI 10.3390/nu16010069
   Cirillo M, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms241914601
   Cohen DJ, 2021, REV ENDOCR METAB DIS, V22, P1057, DOI 10.1007/s11154-021-09659-9
   Corona G, 2006, EUR UROL, V50, P595, DOI 10.1016/j.eururo.2006.02.053
   Cristodoro M, 2024, BIOLOGY-BASEL, V13, DOI 10.3390/biology13020131
   Crook D, 1997, METABOLISM, V46, P735, DOI 10.1016/S0026-0495(97)90115-3
   D'Alessandro A, 2018, INT J FOOD SCI NUTR, V69, P647, DOI 10.1080/09637486.2017.1417978
   Schmitt CD, 2023, BMC ENDOCR DISORD, V23, DOI 10.1186/s12902-023-01278-6
   Damasceno NRT, 2013, ATHEROSCLEROSIS, V230, P347, DOI 10.1016/j.atherosclerosis.2013.08.014
   Davis C, 2015, NUTRIENTS, V7, P9139, DOI 10.3390/nu7115459
   Dayi Taygun, 2022, J Prev Med Hyg, V63, pE56, DOI 10.15167/2421-4248/jpmh2022.63.2S3.2747
   Deaton A, 2008, J ECON PERSPECT, V22, P53, DOI 10.1257/jep.22.2.53
   Defeudis G, 2023, ANDROLOGY-US, V11, P282, DOI 10.1111/andr.13192
   Di Francesco Simona, 2019, Curr Urol, V12, P57, DOI 10.1159/000489420
   Diamanti-Kandarakis E, 2006, TRENDS MOL MED, V12, P324, DOI 10.1016/j.molmed.2006.05.006
   Doustmohammadian A, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.1028394
   Drewnowski A., 2010, Human perceptions and preferences for fat-rich foods, P265, DOI [10.1201/9781420067767-c11, DOI 10.1201/9781420067767-C11]
   Drewnowski A, 2010, AM J CLIN NUTR, V92, P1181, DOI 10.3945/ajcn.2010.29300
   Ehala-Aleksejev K, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194395
   Elfassy Y, 2020, EUR J ENDOCRINOL, V182, P67, DOI 10.1530/EJE-19-0615
   Elsamanoudy AZ, 2016, DIABETOL METAB SYNDR, V8, DOI 10.1186/s13098-016-0192-y
   Engin A, 2017, ADV EXP MED BIOL, V960, P1, DOI 10.1007/978-3-319-48382-5_1
   Esmaeili V, 2015, ANDROLOGY-US, V3, P450, DOI 10.1111/andr.12024
   Esposito K, 2007, INT J IMPOT RES, V19, P486, DOI 10.1038/sj.ijir.3901555
   Esposito K, 2006, INT J IMPOT RES, V18, P405, DOI 10.1038/sj.ijir.3901447
   Esposito K, 2006, INT J IMPOT RES, V18, P370, DOI 10.1038/sj.ijir.3901438
   Esposito K, 2005, INT J IMPOT RES, V17, P391, DOI 10.1038/sj.ijir.3901333
   Esposito K, 2005, INT J IMPOT RES, V17, P224, DOI 10.1038/sj.ijir.3901310
   Esser MB, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2022.39485
   Farland LV, 2021, DIABETOLOGIA, V64, P552, DOI 10.1007/s00125-020-05347-6
   Fatima Q, 2019, DIABETES METAB SYND, V13, P1957, DOI 10.1016/j.dsx.2019.04.032
   FELDMAN HA, 1994, J UROLOGY, V151, P54, DOI 10.1016/S0022-5347(17)34871-1
   Fernandez-Crespo RE, 2021, CURR UROL REP, V22, DOI 10.1007/s11934-020-01030-w
   Figueroa JF, 2020, JAMA-J AM MED ASSOC, V323, P1553, DOI 10.1001/jama.2020.2436
   Fjerbæk A, 2007, EUR J OBSTET GYN R B, V132, P140, DOI 10.1016/j.ejogrb.2006.12.006
   Fontana L, 2007, DIABETES, V56, P1010, DOI 10.2337/db06-1656
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   Gaskins AJ, 2019, AM J OBSTET GYNECOL, V220, DOI 10.1016/j.ajog.2019.02.004
   Gaskins AJ, 2018, AM J OBSTET GYNECOL, V218, P379, DOI 10.1016/j.ajog.2017.08.010
   Giugliano F, 2010, J SEX MED, V7, P1883, DOI 10.1111/j.1743-6109.2010.01714.x
   Giugliano F, 2010, J SEX MED, V7, P1911, DOI 10.1111/j.1743-6109.2010.01713.x
   Gómez-Sánchez L, 2024, NUTRIENTS, V16, DOI 10.3390/nu16121948
   González P, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24119352
   Griswold MG, 2018, LANCET, V392, P1015, DOI [10.1016/S0140-6736(18)31310-2, 10.1016/s0140-6736(18)31310-2]
   Hashim MS, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081939
   Hatzimouratidis K, 2007, J SEX MED, V4, P241, DOI 10.1111/j.1743-6109.2007.00409.x
   He YQ, 2019, AM J OBSTET GYNECOL, V221, DOI 10.1016/j.ajog.2019.03.011
   Herber-Gast GCM, 2013, AM J CLIN NUTR, V97, P1092, DOI 10.3945/ajcn.112.049965
   Hernáez A, 2017, CIRCULATION, V136, P342, DOI 10.1161/CIRCULATIONAHA.117.029013
   Hill DA, 2021, AM FAM PHYSICIAN, V103, P597
   Hjorth MF, 2018, ANNU REV NUTR, V38, P245, DOI 10.1146/annurev-nutr-082117-051606
   Hofmeister S, 2016, AM FAM PHYSICIAN, V94, P236
   Holmes MV, 2014, BMJ-BRIT MED J, V349, DOI 10.1136/bmj.g4164
   Hrelia S, 2023, NUTRIENTS, V15, DOI 10.3390/nu15010175
   Imprialos KP, 2018, CURR VASC PHARMACOL, V16, P130, DOI 10.2174/1570161115666170609101502
   Isidori AM, 2005, CLIN ENDOCRINOL, V63, P381, DOI 10.1111/j.1365-2265.2005.02350.x
   Jurczewska J, 2022, NUTRIENTS, V14, DOI 10.3390/nu14081556
   Karayiannis D, 2018, HUM REPROD, V33, P494, DOI 10.1093/humrep/dey003
   Kastorini CM, 2016, ATHEROSCLEROSIS, V246, P87, DOI 10.1016/j.atherosclerosis.2015.12.025
   Khoo J, 2010, INT J OBESITY, V34, P1396, DOI 10.1038/ijo.2010.76
   Khoo J, 2011, J SEX MED, V8, P2868, DOI 10.1111/j.1743-6109.2011.02417.x
   Kim JE, 2019, MATURITAS, V121, P76, DOI 10.1016/j.maturitas.2018.12.012
   Kindernay L, 2023, REV CARDIOVASC MED, V24, DOI 10.31083/j.rcm2407190
   Kljajic Marija, 2021, J Hum Reprod Sci, V14, P365, DOI 10.4103/jhrs.jhrs_90_21
   Kokot I, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22052295
   Kovács Z, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-37421-5
   Lan Y, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0196012
   Laumann EO, 1999, JAMA-J AM MED ASSOC, V281, P537, DOI 10.1001/jama.281.6.537
   Le Minh Tam, 2020, Metabol Open, V7, P100054, DOI 10.1016/j.metop.2020.100054
   Lee RK, 2012, UROL CLIN N AM, V39, P53, DOI 10.1016/j.ucl.2011.09.008
   Legro RS, 2001, AM J MED, V111, P607, DOI 10.1016/S0002-9343(01)00948-2
   Leisegang K, 2014, ANDROLOGIA, V46, P167, DOI 10.1111/and.12060
   Levin RJ, 2014, PHARMACOL BIOCHEM BE, V121, P62, DOI 10.1016/j.pbb.2014.02.010
   Lewis RW, 2010, J SEX MED, V7, P1598, DOI 10.1111/j.1743-6109.2010.01778.x
   Li BJ, 2023, GYNECOL ENDOCRINOL, V39, DOI 10.1080/09513590.2023.2254844
   Li J, 2021, J OBSTET GYNAECOL RE, V47, P1145, DOI 10.1111/jog.14650
   Li MC, 2020, NUTRIENTS, V12, DOI 10.3390/nu12102955
   Liu LH, 2014, INT J IMPOT RES, V26, P196, DOI 10.1038/ijir.2014.3
   Lizneva D, 2016, FERTIL STERIL, V106, P6, DOI 10.1016/j.fertnstert.2016.05.003
   Lobo RA, 2008, MATURITAS, V60, P10, DOI 10.1016/j.maturitas.2008.02.008
   Lotti F, 2013, ANDROLOGY-US, V1, P229, DOI 10.1111/j.2047-2927.2012.00031.x
   Lotti F, 2018, NAT REV UROL, V15, P287, DOI 10.1038/nrurol.2018.20
   Maiorino MI, 2016, J DIABETES COMPLICAT, V30, P1519, DOI 10.1016/j.jdiacomp.2016.08.007
   Mankowska Aneta, 2009, EJIFCC, V19, P173
   Marmot M, 2008, LANCET, V372, P1661, DOI 10.1016/S0140-6736(08)61690-6
   Martínez-González MA, 2024, AM J CLIN NUTR, V119, P262, DOI 10.1016/j.ajcnut.2023.12.020
   Martini D, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081802
   McCabe MP, 2016, J SEX MED, V13, P135, DOI 10.1016/j.jsxm.2015.12.019
   McPherson NO, 2020, OBES RES CLIN PRACT, V14, P164, DOI 10.1016/j.orcp.2020.03.003
   Mei SS, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.876620
   Meng XH, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1344191
   Meydani M, 2005, NUTR REV, V63, P312, DOI [10.1301/nr.2005.sept.312-314, 10.1111/j.1753-4887.2005.tb00146.x]
   Mohamed S.M., 2023, Food Chem Adv, V3, DOI 10.1016/j.focha.2023.100335
   Mollaioli D, 2020, REPROD BIOL ENDOCRIN, V18, DOI 10.1186/s12958-019-0557-9
   Mondaini N, 2009, J SEX MED, V6, P2772, DOI 10.1111/j.1743-6109.2009.01393.x
   MoradiFili B, 2020, PUBLIC HEALTH NUTR, V23, P833, DOI 10.1017/S1368980019002192
   Morales G, 2021, EUR J NUTR, V60, P1489, DOI 10.1007/s00394-020-02342-w
   Moran LJ, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0161297
   Morgentaler A, 2019, SEX MED REV, V7, P636, DOI 10.1016/j.sxmr.2019.06.003
   Mu F, 2017, HYPERTENSION, V70, P59, DOI 10.1161/HYPERTENSIONAHA.117.09056
   Nagy H., 2023, Dysmenorrhea
   Notario-Barandiaran L, 2020, INT J OBESITY, V44, P1906, DOI 10.1038/s41366-020-0557-z
   Noubiap JJ, 2022, DIABETES RES CLIN PR, V188, DOI 10.1016/j.diabres.2022.109924
   Noubiap JJ, 2022, LANCET CHILD ADOLESC, V6, P158, DOI 10.1016/S2352-4642(21)00374-6
   Oboza P, 2024, NUTRIENTS, V16, DOI 10.3390/nu16121911
   Olabiyi AA, 2022, ANDROLOGIA, V54, DOI 10.1111/and.14424
   Onieva-Zafra MD, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061759
   Ordovas Jose M, 2018, BMJ, V361, DOI 10.1136/bmj.k2173
   Orlich MJ, 2013, JAMA INTERN MED, V173, P1230, DOI 10.1001/jamainternmed.2013.6473
   Orzylowska EM, 2016, EUR J OBSTET GYN R B, V203, P112, DOI 10.1016/j.ejogrb.2016.05.043
   Oszajca K, 2024, CURR NUTR REP, V13, P49, DOI 10.1007/s13668-024-00518-y
   Ou YJ, 2023, J CLIN MED, V12, DOI 10.3390/jcm12134435
   Ouchi N, 2011, NAT REV IMMUNOL, V11, P85, DOI 10.1038/nri2921
   Pandit Kaushik, 2012, Indian J Endocrinol Metab, V16, P44, DOI 10.4103/2230-8210.91187
   Paoli A, 2020, J TRANSL MED, V18, DOI 10.1186/s12967-020-02277-0
   Parazzini F, 2013, REPROD BIOMED ONLINE, V26, P323, DOI 10.1016/j.rbmo.2012.12.011
   Perona JS, 2010, J NUTR BIOCHEM, V21, P892, DOI 10.1016/j.jnutbio.2009.07.005
   Phillips KD, 2004, NURS CLIN N AM, V39, P357, DOI 10.1016/j.cnur.2004.02.004
   Phillips LK, 2008, CURR HYPERTENS REP, V10, P156, DOI 10.1007/s11906-008-0029-7
   Pilatz A, 2017, ANDROLOGY-US, V5, P23, DOI 10.1111/andr.12296
   Poudyal H, 2011, PROG LIPID RES, V50, P372, DOI 10.1016/j.plipres.2011.06.003
   Pu D, 2017, CLIMACTERIC, V20, P583, DOI 10.1080/13697137.2017.1386649
   Qin R, 2022, FRONT CELL INFECT MI, V12, DOI 10.3389/fcimb.2022.1069557
   Quaranta G, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.02653
   Rezig L, 2022, J OLEO SCI, V71, P1117, DOI 10.5650/jos.ess22110
   Ricci E, 2019, AM J OBSTET GYNECOL, V221, DOI 10.1016/j.ajog.2019.07.011
   Robbins WA, 2012, BIOL REPROD, V87, DOI 10.1095/biolreprod.112.101634
   Rosety-Rodriguez M, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/8811153
   Rossi HR, 2021, ACTA OBSTET GYN SCAN, V100, P1248, DOI 10.1111/aogs.14090
   Rowland DL, 2017, SEX MED REV, V5, P272, DOI 10.1016/j.sxmr.2017.03.006
   Saikia Uma Kaimal, 2019, Indian J Endocrinol Metab, V23, P251, DOI 10.4103/ijem.IJEM_574_18
   Salas-Huetos A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061372
   Salas-Huetos A, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-39826-7
   Salas-Huetos A, 2018, AM J CLIN NUTR, V108, P953, DOI 10.1093/ajcn/nqy181
   Samimisedeh P, 2024, J HUM NUTR DIET, V37, P57, DOI 10.1111/jhn.13230
   Sayón-Orea C, 2015, MENOPAUSE, V22, P750, DOI 10.1097/GME.0000000000000378
   Schardt C, 2007, BMC MED INFORM DECIS, V7, DOI 10.1186/1472-6947-7-16
   Schulster ML, 2017, CURR OPIN UROL, V27, P435, DOI 10.1097/MOU.0000000000000426
   Sexual Health, ABOUT US
   Shan J, 2021, ARCH GYNECOL OBSTET, V304, P1363, DOI 10.1007/s00404-021-06057-z
   Simon JA, 2011, J WOMENS HEALTH, V20, P1453, DOI 10.1089/jwh.2010.2151
   Skoracka K, 2020, J CLIN MED, V9, DOI 10.3390/jcm9051400
   Sofi F, 2008, BMJ-BRIT MED J, V337, DOI 10.1136/bmj.a1344
   Solkiewicz K, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23158087
   Solkiewicz K, 2022, J INFLAMM RES, V15, P251, DOI 10.2147/JIR.S341906
   Solkiewicz K, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-85200-x
   Streicher LF, 2023, MENOPAUSE, V30, P635, DOI 10.1097/GME.0000000000002179
   Sun HM, 2019, REPROD BIOL ENDOCRIN, V17, DOI 10.1186/s12958-019-0520-9
   Szamreta EA, 2020, PUBLIC HEALTH NUTR, V23, P1020, DOI 10.1017/S1368980019002349
   Szmidt MK, 2023, NUTRIENTS, V15, DOI 10.3390/nu15092131
   Tal R, 2016, Male Sexual Dysfunction, P1, DOI [10.1002/9781118746509.CH1, DOI 10.1002/9781118746509.CH1, 10.1002/9781118746509.ch1]
   Toledo E, 2011, FERTIL STERIL, V96, P1149, DOI 10.1016/j.fertnstert.2011.08.034
   Towe M, 2020, SEX MED REV, V8, P256, DOI 10.1016/j.sxmr.2019.08.004
   Traish AM, 2015, REV ENDOCR METAB DIS, V16, P249, DOI 10.1007/s11154-015-9323-2
   Tuttolomondo A, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20194716
   Vander Borght M, 2018, CLIN BIOCHEM, V62, P2, DOI 10.1016/j.clinbiochem.2018.03.012
   Varlamov O, 2017, BBA-MOL BASIS DIS, V1863, P1147, DOI 10.1016/j.bbadis.2016.05.025
   Velez LM, 2021, BIOL REPROD, V104, P1205, DOI 10.1093/biolre/ioab050
   Ventimiglia E, 2016, ANDROLOGY-US, V4, P944, DOI 10.1111/andr.12232
   Vetrani C, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.886824
   Vinciguerra F, 2020, LIFE-BASEL, V10, DOI 10.3390/life10080127
   Vinciguerra F, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041019
   Vujkovic M, 2010, FERTIL STERIL, V94, P2096, DOI 10.1016/j.fertnstert.2009.12.079
   Walker RE, 2010, HEALTH PLACE, V16, P876, DOI 10.1016/j.healthplace.2010.04.013
   Wang Q, 2022, NUTR RES, V100, P1, DOI 10.1016/j.nutres.2021.12.006
   Widmer RJ, 2015, AM J MED, V128, P229, DOI 10.1016/j.amjmed.2014.10.014
   World Health Organization (WHO), Polycystic ovary syndrome Internet
   Wu SI, 2001, J CLIN EPIDEMIOL, V54, P117, DOI 10.1016/S0895-4356(00)00284-5
   Yalcin Bahat Pinar, 2022, Acta Biomed, V93, pe2022159, DOI 10.23750/abm.v93i1.11237
   Yamagishi K, 2017, EPIDEMIOL HEALTH, V39, DOI 10.4178/epih.e2017003
   Yang PK, 2021, MOL METAB, V49, DOI 10.1016/j.molmet.2021.101189
   Yildiz BO, 2012, HUM REPROD, V27, P3067, DOI 10.1093/humrep/des232
   Yuan M, 2018, HUM REPROD, V33, P607, DOI 10.1093/humrep/dex372
NR 195
TC 3
Z9 3
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2024
VL 16
IS 19
AR 3397
DI 10.3390/nu16193397
PG 27
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA I7P5V
UT WOS:001332143000001
PM 39408364
OA gold
DA 2025-06-11
ER

PT J
AU Nishikawa, H
   Asai, A
   Fukunishi, S
   Nishiguchi, S
   Higuchi, K
AF Nishikawa, Hiroki
   Asai, Akira
   Fukunishi, Shinya
   Nishiguchi, Shuhei
   Higuchi, Kazuhide
TI Metabolic Syndrome and Sarcopenia
SO NUTRIENTS
LA English
DT Review
DE metabolic syndrome; sarcopenia; mechanism; insulin resistance;
   sarcopenic obesity; outcome
ID FATTY LIVER-DISEASE; MUSCLE MASS; VITAMIN-D; ELDERLY-MEN; POSTMENOPAUSAL
   WOMEN; INSULIN-RESISTANCE; ADIPOSE-TISSUE; OLDER-ADULTS;
   25-HYDROXYVITAMIN D; PHYSICAL FUNCTION
AB Skeletal muscle is a major organ of insulin-induced glucose metabolism. In addition, loss of muscle mass is closely linked to insulin resistance (IR) and metabolic syndrome (Met-S). Skeletal muscle loss and accumulation of intramuscular fat are associated with a variety of pathologies through a combination of factors, including oxidative stress, inflammatory cytokines, mitochondrial dysfunction, IR, and inactivity. Sarcopenia, defined by a loss of muscle mass and a decline in muscle quality and muscle function, is common in the elderly and is also often seen in patients with acute or chronic muscle-wasting diseases. The relationship between Met-S and sarcopenia has been attracting a great deal of attention these days. Persistent inflammation, fat deposition, and IR are thought to play a complex role in the association between Met-S and sarcopenia. Met-S and sarcopenia adversely affect QOL and contribute to increased frailty, weakness, dependence, and morbidity and mortality. Patients with Met-S and sarcopenia at the same time have a higher risk of several adverse health events than those with either Met-S or sarcopenia. Met-S can also be associated with sarcopenic obesity. In this review, the relationship between Met-S and sarcopenia will be outlined from the viewpoints of molecular mechanism and clinical impact.</p>
C1 [Nishikawa, Hiroki; Asai, Akira; Fukunishi, Shinya; Higuchi, Kazuhide] Osaka Med & Pharmaceut Univ, Dept Internal Med 2, Takatsuki, Osaka 5698686, Japan.
   [Nishikawa, Hiroki; Fukunishi, Shinya] Osaka Med & Pharmaceut Univ, Premier Dept Res Med, Takatsuki, Osaka 5698686, Japan.
   [Nishiguchi, Shuhei] Kano Gen Hosp, Osaka 5310041, Japan.
C3 Osaka Medical & Pharmaceutical University; Osaka Medical &
   Pharmaceutical University
RP Nishikawa, H (corresponding author), Osaka Med & Pharmaceut Univ, Dept Internal Med 2, Takatsuki, Osaka 5698686, Japan.; Nishikawa, H (corresponding author), Osaka Med & Pharmaceut Univ, Premier Dept Res Med, Takatsuki, Osaka 5698686, Japan.
EM nishikawa_6392@yahoo.co.jp; in2108@osaka-med.ac.jp;
   in2104@osaka-med.ac.jp; nishiguchi@heartfull.or.jp;
   kazuhide.higuchi@ompu.ac.jp
OI Asai, Akira/0000-0002-2915-7875
CR Ahuja V, 2015, DIABETOLOGIA, V58, P265, DOI 10.1007/s00125-014-3414-6
   Akter S, 2017, NUTRITION, V36, P26, DOI 10.1016/j.nut.2016.02.024
   Pérez EA, 2018, NUTRIENTS, V10, DOI 10.3390/nu10070878
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Aleixo GFP, 2020, CRIT REV ONCOL HEMAT, V145, DOI 10.1016/j.critrevonc.2019.102839
   Alexandre TD, 2018, CLIN NUTR, V37, P1360, DOI 10.1016/j.clnu.2017.06.009
   Almind K, 2007, P NATL ACAD SCI USA, V104, P2366, DOI 10.1073/pnas.0610416104
   Anker SD, 2014, J CACHEXIA SARCOPENI, V5, P1, DOI 10.1007/s13539-014-0135-0
   Asano L, 2017, CELL CHEM BIOL, V24, P207, DOI 10.1016/j.chembiol.2016.12.017
   Atakan MM, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051459
   Baczek J, 2020, NUTRIENTS, V12, DOI 10.3390/nu12082401
   Baek SJ, 2014, J ENDOCRINOL INVEST, V37, P247, DOI 10.1007/s40618-013-0011-3
   Barajas-Galindo DE, 2021, ENDOCRINOL DIAB NUTR, V68, P159, DOI 10.1016/j.endinu.2020.02.010
   Barbalho SM, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21103607
   Baumgartner RN, 1999, MECH AGEING DEV, V107, P123, DOI 10.1016/S0047-6374(98)00130-4
   Baumgartner RN, 2004, OBES RES, V12, P1995, DOI 10.1038/oby.2004.250
   Bonaldo P, 2013, DIS MODEL MECH, V6, P25, DOI 10.1242/dmm.010389
   Chen LK, 2020, J AM MED DIR ASSOC, V21, P300, DOI 10.1016/j.jamda.2019.12.012
   Churilla JR, 2020, J STRENGTH COND RES, V34, P995, DOI 10.1519/JSC.0000000000003515
   Cleasby ME, 2016, J ENDOCRINOL, V229, pR67, DOI 10.1530/JOE-15-0533
   Consitt LA, 2018, J FRALITY AGING, V7, P21, DOI 10.14283/jfa.2017.33
   Crawford J, 2016, CURR ONCOL REP, V18, DOI 10.1007/s11912-016-0522-0
   Cruz-Jentoft AJ, 2019, AGE AGEING, V48, P16, DOI 10.1093/ageing/afy169
   Dalton JT, 2011, J CACHEXIA SARCOPENI, V2, P153, DOI 10.1007/s13539-011-0034-6
   Dominguez Ligia J, 2007, J Cardiometab Syndr, V2, P183, DOI 10.1111/j.1559-4564.2007.06673.x
   Dong M, 2018, FRONT MED-PRC, V12, P130, DOI 10.1007/s11684-017-0555-2
   Drummond MJ, 2008, CURR OPIN CLIN NUTR, V11, P222, DOI 10.1097/MCO.0b013e3282fa17fb
   Dulai PS, 2017, HEPATOLOGY, V65, P1557, DOI 10.1002/hep.29085
   Eguchi Y, 2012, J GASTROENTEROL, V47, P586, DOI 10.1007/s00535-012-0533-z
   Eliades M, 2013, ALIMENT PHARM THER, V38, P246, DOI 10.1111/apt.12377
   Rubio-Ruiz ME, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20030647
   Frigolet ME, 2020, GAC MED MEX, V156, P142, DOI 10.24875/GMM.M20000356
   Gluvic Z, 2017, CURR VASC PHARMACOL, V15, P30, DOI 10.2174/1570161114666161007164510
   Gnagnarella P, 2020, ADV EXP MED BIOL, V1268, P53, DOI 10.1007/978-3-030-46227-7_4
   Griffiths RD, 1996, NUTRITION, V12, P456, DOI 10.1016/S0899-9007(96)00141-4
   Habig G, 2021, METABOLITES, V11, DOI 10.3390/metabo11040242
   Haddad F, 2005, J APPL PHYSIOL, V98, P911, DOI 10.1152/japplphysiol.01026.2004
   Hajhashemy Z, 2021, OBES REV, V22, DOI 10.1111/obr.13223
   Hamaguchi M, 2005, ANN INTERN MED, V143, P722, DOI 10.7326/0003-4819-143-10-200511150-00009
   Hamer M, 2009, AGE, V31, P171, DOI 10.1007/s11357-009-9097-0
   Han K, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0086902
   Harwood HJ, 2012, NEUROPHARMACOLOGY, V63, P57, DOI 10.1016/j.neuropharm.2011.12.010
   Heber David, 1996, American Journal of Clinical Nutrition, V64, p472S, DOI 10.1093/ajcn/64.3.472S
   Inoue M, 2008, ANN EPIDEMIOL, V18, P522, DOI 10.1016/j.annepidem.2008.03.008
   Ishii S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0112718
   Kalinkovich A, 2017, AGEING RES REV, V35, P200, DOI 10.1016/j.arr.2016.09.008
   Kalyani RR, 2014, LANCET DIABETES ENDO, V2, P819, DOI 10.1016/S2213-8587(14)70034-8
   Kim G, 2018, HEPATOLOGY, V68, P1755, DOI 10.1002/hep.30049
   Kim G, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0659-2
   Kim SH, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0248856
   Kim TN, 2009, INT J OBESITY, V33, P885, DOI 10.1038/ijo.2009.130
   Kim TN, 2010, DIABETES CARE, V33, P1497, DOI 10.2337/dc09-2310
   Kitamoto T, 2013, HUM GENET, V132, P783, DOI 10.1007/s00439-013-1294-3
   Koda M, 2007, J GASTROENTEROL, V42, P897, DOI 10.1007/s00535-007-2107-z
   Kong XX, 2018, CELL METAB, V28, P631, DOI 10.1016/j.cmet.2018.07.004
   Koo BK, 2017, J HEPATOL, V66, P123, DOI 10.1016/j.jhep.2016.08.019
   Leong DP, 2015, LANCET, V386, P266, DOI 10.1016/S0140-6736(14)62000-6
   Lim JP, 2015, CLIN INTERV AGING, V10, P605, DOI 10.2147/CIA.S78901
   Loomba R, 2013, NAT REV GASTRO HEPAT, V10, P686, DOI 10.1038/nrgastro.2013.171
   Lu CW, 2013, OBES RES CLIN PRACT, V7, pE301, DOI 10.1016/j.orcp.2012.02.003
   Meng G, 2016, SCI REP-UK, V6, DOI 10.1038/srep33255
   Mukai N, 2009, DIABETES CARE, V32, P2288, DOI 10.2337/dc09-0896
   Nishikawa H, 2016, HEPATOL RES, V46, P951, DOI 10.1111/hepr.12774
   Oh C, 2015, NUTR RES, V35, P1, DOI 10.1016/j.nutres.2014.07.018
   Pacifico L, 2019, HEPATOBIL SURG NUTR, V8, P144, DOI 10.21037/hbsn.2018.11.11
   Pan XY, 2018, DIGEST DIS, V36, P427, DOI 10.1159/000491015
   Pang Q, 2016, HEPATOLOGY, V63, P675, DOI 10.1002/hep.28010
   Park SJ, 2019, METAB SYNDR RELAT D, V17, P494, DOI 10.1089/met.2019.0059
   Park SH, 2020, EUR J CLIN NUTR, V74, P1401, DOI 10.1038/s41430-020-0591-x
   Pellegrinelli V, 2015, DIABETES, V64, P3121, DOI 10.2337/db14-0796
   Postic C, 2008, J CLIN INVEST, V118, P829, DOI 10.1172/JCI34275
   Prado CMM, 2008, LANCET ONCOL, V9, P629, DOI 10.1016/S1470-2045(08)70153-0
   Remelli F, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122861
   Rinella ME, 2015, JAMA-J AM MED ASSOC, V313, P2263, DOI 10.1001/jama.2015.5370
   Rubio-Ruiz M.E., 2012, HDB METABOLIC SYNDRO, P169
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sanada K, 2012, EUR J CLIN NUTR, V66, P1093, DOI 10.1038/ejcn.2012.43
   Shen C, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2020-041384
   Son JW, 2017, DIABETOLOGIA, V60, P865, DOI 10.1007/s00125-016-4196-9
   Sone H, 2003, LANCET, V361, P85, DOI 10.1016/S0140-6736(03)12151-4
   Stenholm S, 2008, CURR OPIN CLIN NUTR, V11, P693, DOI 10.1097/MCO.0b013e328312c37d
   Sugimoto K, 2019, J DIABETES INVEST, V10, P1471, DOI 10.1111/jdi.13070
   Tabrizi R, 2019, EXCLI J, V18, P591, DOI 10.17179/excli2019-1386
   Tamura Y, 2019, ENDOCR J, V66, P1, DOI 10.1507/endocrj.EJ18-0435
   Tiidus PM, 2013, J APPL PHYSIOL, V115, P569, DOI 10.1152/japplphysiol.00629.2013
   Tilg H, 2006, NAT REV IMMUNOL, V6, P772, DOI 10.1038/nri1937
   Tyrovolas S, 2015, EXP GERONTOL, V69, P27, DOI 10.1016/j.exger.2015.06.002
   Uchitomi R, 2020, NUTRIENTS, V12, DOI 10.3390/nu12103189
   Vimaleswaran KS, 2013, PLOS MED, V10, DOI 10.1371/journal.pmed.1001383
   Visser M, 2002, J GERONTOL A-BIOL, V57, pM326, DOI 10.1093/gerona/57.5.M326
   Walsh K, 2009, CIRC J, V73, P13, DOI 10.1253/circj.CJ-08-0961
   Walsh MC, 2006, OSTEOPOROSIS INT, V17, P61, DOI 10.1007/s00198-005-1900-x
   Wijarnpreecha K, 2018, SAUDI J GASTROENTERO, V24, P12, DOI 10.4103/sjg.SJG_237_17
   Wu HM, 2019, METABOLISM, V93, P61, DOI 10.1016/j.metabol.2019.01.011
   Wu SE, 2021, ANN NY ACAD SCI, V1503, P60, DOI 10.1111/nyas.14607
   Yoon JW, 2016, DIABETES METAB J, V40, P140, DOI 10.4093/dmj.2016.40.2.140
   Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431
   Younossi ZM, 2011, CLIN GASTROENTEROL H, V9, P524, DOI 10.1016/j.cgh.2011.03.020
   Yu R, 2018, BMC GASTROENTEROL, V18, DOI 10.1186/s12876-018-0776-0
   Zhang HQ, 2018, NUTRIENTS, V10, DOI 10.3390/nu10030364
   Zhou LS, 2015, DRUG AGING, V32, P727, DOI 10.1007/s40266-015-0288-3
   Zisman A, 2000, NAT MED, V6, P924, DOI 10.1038/78693
   Zmijewski MA, 2020, EXP DERMATOL, V29, P876, DOI 10.1111/exd.14147
NR 103
TC 176
Z9 183
U1 16
U2 81
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2021
VL 13
IS 10
AR 3519
DI 10.3390/nu13103519
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA WT9CV
UT WOS:000716155900001
PM 34684520
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Al Shammaa, A
   Al-Thani, A
   Al-Kaabi, M
   Al-Saeed, K
   Alanazi, M
   Shi, ZM
AF Al Shammaa, AlMaha
   Al-Thani, Amna
   Al-Kaabi, Maryam
   Al-Saeed, Kaltham
   Alanazi, Maria
   Shi, Zumin
TI Serum Magnesium is Inversely Associated with Body Composition and
   Metabolic Syndrome
SO DIABETES METABOLIC SYNDROME AND OBESITY
LA English
DT Article
DE serum magnesium; DEXA; body adiposity; total fat mass; Qatar Biobank;
   cross-sectional study
ID INSULIN-RESISTANCE; OBESITY; METAANALYSIS; RISK; DEPRESSION; CHILDREN;
   PLASMA; QATAR
AB Purpose: Magnesium is vital to maintain normal physiological functions. We aimed to identify the association between serum magnesium and different measures of body adiposity among Qatari adults. We hypothesized that the association was mediated by depression and sleep duration. Patients and Methods: The study included 1000 adults aged 20 years and above who attended the Qatar Biobank Study (QBB) between 2012 and 2019. Body adiposity was assessed using dual-energy X-ray absorptiometry (DEXA). Serum magnesium concen-tration was measured. Sub-optimal magnesium was defined as magnesium concentration less than 0.85 mmol/L. The association was examined using linear regression. Results: The mean age of the participants (n=1000) was 35.8 (SD 10.3) years. More than half of the participants had sub-optimal magnesium concentrations (60.2% in men and 52.3% in women). Serum magnesium was inversely associated with different types of fat mass. In the fully adjusted model, per 1 SD increment of serum magnesium had standardized regression coefficients of -0.09 (p 0.005) for total fat mass, -0.08 (p 0.008) for trunk fat, -0.09 (p 0.003) for gynoid fat and -0.08 (p 0.008) for android fat. There was no gender difference in the association. The inverse association between serum magnesium and fat mass was significant in those with sleep duration >= 7 hours but not in those <7 hours. Depressive symptom and sleep did not mediate the association between serum magnesium and fat mass. Serum magnesium was inversely associated with metabolic syndrome (per 1 SD increment had an odds ratio (OR) of 0.70 (95% CI 0.57-0.85)). Conclusion: There was an inverse association between serum magnesium and fat mass, especially among those with an adequate sleep duration and without chronic conditions including diabetes, hypertension and depression.
C1 [Al Shammaa, AlMaha; Al-Thani, Amna; Al-Kaabi, Maryam; Al-Saeed, Kaltham; Alanazi, Maria; Shi, Zumin] Qatar Univ, Coll Hlth Sci, Human Nutr Dept, QU Hlth, Doha, Qatar.
   [Shi, Zumin] Qatar Univ, Coll Hlth Sci, Human Nutr Dept, QU Hlth, POB 2713, Doha, Qatar.
C3 Qatar University; Qatar University
RP Shi, ZM (corresponding author), Qatar Univ, Coll Hlth Sci, Human Nutr Dept, QU Hlth, POB 2713, Doha, Qatar.
EM zumin@qu.edu.qa
RI Alanazi, Maria/HZI-6306-2023; Shi, Zumin/A-1093-2009
OI Shi, Zumin/0000-0002-3099-3299
FU Qatar University [QUST-1-CHS-2022-348]; Qatar National Library
FX Acknowledgments The authors would like to thank Qatar Biobank for
   providing the data. This research was supported by a grant from Qatar
   University (Grant No: QUST-1-CHS-2022-348) . The funders had no role in
   the study design, data collection and analysis, decision to publish, or
   preparation of the manuscript. The publication of this article was
   funded by the Qatar National Library.
CR Al Kuwari H, 2015, BMC PUBLIC HEALTH, V15, DOI 10.1186/s12889-015-2522-7
   Al Thani A, 2019, AM J EPIDEMIOL, V188, P1420, DOI 10.1093/aje/kwz084
   Al-Thani M, 2017, CUREUS J MED SCIENCE, V9, DOI 10.7759/cureus.1249
   Alaradi M, 2021, PUBLIC HEALTH NUTR, V24, P4506, DOI 10.1017/S1368980020003572
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
   Askari M, 2021, CRIT REV FOOD SCI, V61, P2921, DOI 10.1080/10408398.2020.1790498
   Badawi A, 2012, J PUBLIC HEALTH RES, V1, P229, DOI 10.4081/jphr.2012.e36
   Cao YT, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101354
   Cappuccio FP, 2008, SLEEP, V31, P619, DOI 10.1093/sleep/31.5.619
   Carretero OA, 2000, CIRCULATION, V101, P329, DOI 10.1161/01.CIR.101.3.329
   Castellanos-Gutiérrez A, 2018, NUTR J, V17, DOI 10.1186/s12937-018-0422-2
   Corica F, 1997, AM J HYPERTENS, V10, P1311
   Costello RB, 2016, ADV NUTR, V7, P977, DOI 10.3945/an.116.012765
   Crowley EK, 2018, MAR DRUGS, V16, DOI 10.3390/md16060216
   de Baaij JHF, 2015, PHYSIOL REV, V95, P1, DOI 10.1152/physrev.00012.2014
   de Wit L, 2010, PSYCHIAT RES, V178, P230, DOI 10.1016/j.psychres.2009.04.015
   Derom ML, 2013, NUTR NEUROSCI, V16, P191, DOI 10.1179/1476830512Y.0000000044
   DiNicolantonio JJ, 2018, OPEN HEART, V5, DOI 10.1136/openhrt-2017-000668
   Dominguez LJ, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010125
   Dong JY, 2011, DIABETES CARE, V34, P2116, DOI 10.2337/dc11-0518
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Gallagher D, 2000, AM J CLIN NUTR, V72, P694, DOI 10.1093/ajcn/72.3.694
   Geeta Shamnani Geeta Shamnani, 2018, National Journal of Physiology, Pharmacy and Pharmacology, V8, P1074
   Gruzdeva O, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0856-8
   Huang JH, 2012, NUTR J, V11, DOI 10.1186/1475-2891-11-41
   Huerta MG, 2005, DIABETES CARE, V28, P1175, DOI 10.2337/diacare.28.5.1175
   Inker LA, 2012, NEW ENGL J MED, V367, P20, DOI 10.1056/NEJMoa1114248
   Jahnen-Dechent W, 2012, CLIN KIDNEY J, V5, P3, DOI 10.1093/ndtplus/sfr163
   Kerkadi A, 2020, DIABET METAB SYND OB, V13, P175, DOI 10.2147/DMSO.S238748
   Lu LP, 2020, EUR J NUTR, V59, P3745, DOI 10.1007/s00394-020-02206-3
   Nielsen FH, 2010, NUTR REV, V68, P333, DOI 10.1111/j.1753-4887.2010.00293.x
   Piuri G, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020320
   Rahman H., 2018, Civil Eng Res J Desalination in Qatar: Present Status and Future Prospects, DOI [DOI 10.19080/CERJ.2018.06.555700, 10.19080/cerj.2018.06.555700]
   Randell EW, 2008, ATHEROSCLEROSIS, V196, P413, DOI 10.1016/j.atherosclerosis.2006.11.024
   Razzaque MS, 2018, NUTRIENTS, V10, DOI 10.3390/nu10121863
   Rodríguez-Morán M, 2004, MAGNESIUM RES, V17, P189
   Rowell C, 2015, J WATER HEALTH, V13, P437, DOI 10.2166/wh.2014.128
   Shi ZM, 2019, DIABETES RES CLIN PR, V158, DOI 10.1016/j.diabres.2019.107903
   Swaminathan R, 2003, Clin Biochem Rev, V24, P47
   Taheri S, 2021, LANCET DIABETES ENDO, V9, P561, DOI 10.1016/S2213-8587(21)00209-6
   Tang HL, 2016, DIABETOLOGIA, V59, P2546, DOI 10.1007/s00125-016-4101-6
   Yang N, 2020, DIABET METAB SYND OB, V13, P2541, DOI 10.2147/DMSO.S257884
   You HJ, 2018, NORD J PSYCHIAT, V72, P534, DOI 10.1080/08039488.2018.1538388
   Zaakouk AM, 2016, EGYPT PEDIATR ASSO, V64, P32, DOI 10.1016/j.epag.2015.11.002
   Zheltova AA, 2016, BIOMEDICINE-TAIWAN, V6, P8, DOI 10.7603/s40681-016-0020-6
NR 46
TC 9
Z9 9
U1 1
U2 5
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2023
VL 16
BP 95
EP 104
DI 10.2147/DMSO.S391369
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 7Z0LP
UT WOS:000915259000001
PM 36760601
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Agrawal, A
   Mabalirajan, U
   Ahmad, T
   Ghosh, B
AF Agrawal, Anurag
   Mabalirajan, Ulaganathan
   Ahmad, Tanveer
   Ghosh, Balaram
TI Emerging Interface between Metabolic Syndrome and Asthma
SO AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
LA English
DT Review
DE ADMA; hyperinsulinism; obesity; arginine; mitochondrial dysfunction
ID BODY-MASS INDEX; GROWTH-FACTOR-I; ASYMMETRIC DIMETHYLARGININE;
   INSULIN-RESISTANCE; DIABETES-MELLITUS; CLUSTER-ANALYSIS; INCIDENT
   ASTHMA; LUNG-FUNCTION; NITRIC-OXIDE; MOUSE MODEL
AB There is growing epidemiological evidence that obesity increases the risk of developing asthma. In some studies, insulin resistance or metabolic syndrome is a stronger risk factor than body mass. The obese-asthma subphenotype is marked by a paucity of inflammation but also by marked symptoms, poor response to glucocorticoids, and peripheral airway dysfunction. Although obesity may predispose to increased Th2 inflammation or atopic tendencies, other mechanisms that are independent of inflammatory cells need to be considered. There is growing evidence of the influence of hyperglycemia, hyperinsulinemia, and insulin-like growth factors on airway structure and function. Also, studies from mouse models of asthma have highlighted the importance of nitric oxide-arginine metabolism abnormalities and oxonitrosative stress in lungs. Such changes are well established features of the metabolic syndrome and may represent an interface between these diseases that can be therapeutically targeted. Such therapies, including administration of L-arginine or statins, increasing endothelial nitric oxide synthase, or the use of arginase inhibitors, have been successful in experimental models but have not yet translated to the clinical arena. We review the current understanding of the potential mechanistic links between obesity and asthma, emphasizing the potential influence of metabolic abnormalities on asthmatic processes, therapeutic implications, and expected challenges.
C1 [Agrawal, Anurag; Mabalirajan, Ulaganathan; Ahmad, Tanveer; Ghosh, Balaram] Inst Genom & Integrat Biol, Ctr Translat Res Asthma & Lung Dis, Delhi, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Institute of Genomics & Integrative Biology (IGIB)
RP Agrawal, A (corresponding author), Inst Genom & Integrat Biol, Ctr Translat Res Asthma & Lung Dis, Mall Rd, Delhi, India.
EM a.agrawal@igib.in
RI Agrawal, Anurag/A-7312-2009; Ahmad, Tanveer/ABX-8334-2022; Ghosh,
   Balaram/G-1248-2010
OI Ahmad, Tanveer/0000-0002-8384-5273; Mabalirajan,
   Ulaganathan/0000-0002-2547-1023; Agrawal, Anurag/0000-0002-0340-5252
FU Council of Scientific and Industrial Research, India [MLP5501, NWP33];
   BIOMARCK Pharmaceuticals
FX This work was supported by grants MLP5501 and NWP33 of Council of
   Scientific and Industrial Research, India. A.A. received a sponsored
   grant from BIOMARCK Pharmaceuticals for $10,001 to $50,000. T.A. does
   not have a financial relationship with a commercial entity that has an
   interest in the subject of this manuscript. B.G. does not have a
   financial relationship with a commercial entity that has an interest in
   the subject of this manuscript. U.M. does not have a financial
   relationship with a commercial entity that has an interest in the
   subject of this manuscript.
CR Aaron SD, 2008, CAN MED ASSOC J, V179, P1121, DOI 10.1503/cmaj.081332
   Abbasi F, 2000, J CLIN ENDOCR METAB, V85, P1251, DOI 10.1210/jc.85.3.1251
   Agrawal A, 2007, J APPL PHYSIOL, V102, P399, DOI 10.1152/japplphysiol.00630.2006
   Agrawal A, 2009, PHYSIOL GENOMICS, V40, P1, DOI 10.1152/physiolgenomics.00141.2009
   Aguilera-Aguirre L, 2009, J IMMUNOL, V183, P5379, DOI 10.4049/jimmunol.0900228
   Ahmad T, 2010, AM J RESP CELL MOL, V42, P3, DOI 10.1165/rcmb.2009-0137RC
   [Anonymous], [No title captured]
   [Anonymous], [No title captured]
   Appleton SL, 2006, J ALLERGY CLIN IMMUN, V118, P1284, DOI 10.1016/j.jaci.2006.08.011
   Attia N, 1998, J CLIN ENDOCR METAB, V83, P1467, DOI 10.1210/jc.83.5.1467
   Beuther DA, 2006, AM J RESP CRIT CARE, V174, P112, DOI 10.1164/rccm.200602-231PP
   Beuther DA, 2007, AM J RESP CRIT CARE, V175, P661, DOI 10.1164/rccm.200611-1717OC
   Beuther DA, 2010, CURR OPIN PULM MED, V16, P64, DOI 10.1097/MCP.0b013e3283338fa7
   Booth BW, 2003, CHEST, V123, p384S, DOI 10.1378/chest.123.3_suppl.384S
   Camargo CA, 1999, ARCH INTERN MED, V159, P2582, DOI 10.1001/archinte.159.21.2582
   Carreras MC, 2007, AM J PHYSIOL-CELL PH, V292, pC1569, DOI 10.1152/ajpcell.00248.2006
   Dekkers BGJ, 2009, AM J RESP CELL MOL, V41, P494, DOI 10.1165/rcmb.2008-0251OC
   Delgado J, 2008, J INVEST ALLERG CLIN, V18, P420
   Dupont J, 2001, ENDOCRINOLOGY, V142, P4969, DOI 10.1210/en.142.11.4969
   Elbein SC, 2009, DIABETES, V58, P268, DOI 10.2337/db08-0931
   Fujii T, 2008, AM J PHYSIOL-HEART C, V294, pH2785, DOI 10.1152/ajpheart.00149.2008
   Gosens R, 2003, EUR J PHARMACOL, V481, P125, DOI 10.1016/j.ejphar.2003.08.081
   Haldar P, 2008, AM J RESP CRIT CARE, V178, P218, DOI 10.1164/rccm.200711-1754OC
   Hjellvik V, 2010, EUR RESPIR J, V35, P1235, DOI 10.1183/09031936.00192408
   Holgate Stephen T, 2008, Allergol Int, V57, P1, DOI 10.2332/allergolint.R-07-154
   Hothersall EJ, 2008, THORAX, V63, P1070, DOI 10.1136/thx.2008.100198
   Huang PL, 2009, TRENDS ENDOCRIN MET, V20, P295, DOI 10.1016/j.tem.2009.03.005
   Husemoen LLN, 2008, ALLERGY, V63, P575, DOI 10.1111/j.1398-9995.2007.01613.x
   Johnston RA, 2007, AM J RESP CRIT CARE, V176, P650, DOI 10.1164/rccm.200702-323OC
   Kretowski A, 2000, SCAND J IMMUNOL, V51, P321
   Lara A, 2008, AM J RESP CRIT CARE, V178, P673, DOI 10.1164/rccm.200710-1542OC
   Lee EJ, 2009, J ASTHMA, V46, P339, DOI 10.1080/02770900802660931
   Lu TM, 2004, AM J CARDIOL, V94, P157, DOI 10.1016/j.amjcard.2004.03.052
   Lucotti P, 2006, AM J PHYSIOL-ENDOC M, V291, pE906, DOI 10.1152/ajpendo.00002.2006
   Mabalirajan U, 2008, J IMMUNOL, V181, P3540, DOI 10.4049/jimmunol.181.5.3540
   Mabalirajan U, 2010, J ALLERGY CLIN IMMUN, V125, P626, DOI 10.1016/j.jaci.2009.10.065
   Mabalirajan U, 2009, AM J PHYSIOL-LUNG C, V297, pL411, DOI 10.1152/ajplung.00138.2009
   McKay A, 2004, J IMMUNOL, V172, P2903, DOI 10.4049/jimmunol.172.5.2903
   Menzies D, 2007, J ALLERGY CLIN IMMUN, V119, P328, DOI 10.1016/j.jaci.2006.10.014
   Moore WC, 2010, AM J RESP CRIT CARE, V181, P315, DOI 10.1164/rccm.200906-0896OC
   Morris CR, 2004, AM J RESP CRIT CARE, V170, P148, DOI 10.1164/rccm.200309-1304OC
   Mucenski ML, 2005, AM J PHYSIOL-LUNG C, V289, pL971, DOI 10.1152/ajplung.00172.2005
   Nisoli E, 2006, J CELL SCI, V119, P2855, DOI 10.1242/jcs.03062
   Ostroukhova M, 2009, ANN ALLERG ASTHMA IM, V103, P463, DOI 10.1016/S1081-1206(10)60261-X
   Pakhale S, 2010, CHEST, V137, P1316, DOI 10.1378/chest.09-2491
   Reaven Gerald M, 2003, Curr Atheroscler Rep, V5, P364, DOI 10.1007/s11883-003-0007-0
   Schaafsma D, 2007, BRIT J PHARMACOL, V150, P136, DOI 10.1038/sj.bjp.0706985
   Scholtens S, 2010, INT J OBESITY, V34, P606, DOI 10.1038/ijo.2009.194
   Sharma M, 2008, AM J RESP CRIT CARE, V177, P712, DOI 10.1164/rccm.200705-781OC
   Shiffman D, 2006, ARTERIOSCL THROM VAS, V26, P1613, DOI 10.1161/01.ATV.0000226543.77214.e4
   Sud N, 2008, AM J PHYSIOL-CELL PH, V294, pC1407, DOI 10.1152/ajpcell.00384.2007
   Sutherland TJT, 2008, AM J RESP CRIT CARE, V178, P469, DOI 10.1164/rccm.200802-301OC
   Terzano C, 2009, J ASTHMA, V46, P703, DOI 10.1080/02770900903056203
   Thuesen BH, 2009, CLIN EXP ALLERGY, V39, P700, DOI 10.1111/j.1365-2222.2008.03197.x
   Von Behren J, 2009, THORAX, V64, P889, DOI 10.1136/thx.2009.114579
   Wasir J S, 2008, J Assoc Physicians India, V56, P158
   Weiss R, 2010, ENDOCR DEV, V19, P62, DOI 10.1159/000316898
   Wells SM, 2009, AM J RESP CELL MOL, V40, P179, DOI 10.1165/rcmb.2008-0148OC
   Wu GY, 2007, J NUTR, V137, P2680, DOI 10.1093/jn/137.12.2680
   Wu GY, 2009, AMINO ACIDS, V37, P153, DOI 10.1007/s00726-008-0210-y
   Yamashita N, 2005, CELL IMMUNOL, V235, P85, DOI 10.1016/j.cellimm.2005.07.006
   Zeki AA, 2009, AM J RESP CRIT CARE, V180, P731, DOI 10.1164/rccm.200901-0018OC
NR 62
TC 88
Z9 91
U1 2
U2 16
PU AMER THORACIC SOC
PI NEW YORK
PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA
SN 1044-1549
EI 1535-4989
J9 AM J RESP CELL MOL
JI Am. J. Respir. Cell Mol. Biol.
PD MAR
PY 2011
VL 44
IS 3
BP 270
EP 275
DI 10.1165/rcmb.2010-0141TR
PG 6
WC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
GA 753KN
UT WOS:000289772400004
PM 20656947
DA 2025-06-11
ER

PT J
AU dos Santos, LRB
   Fleming, I
AF dos Santos, Laila R. B.
   Fleming, Ingrid
TI Role of cytochrome P450-derived, polyunsaturated fatty acid mediators in
   diabetes and the metabolic syndrome
SO PROSTAGLANDINS & OTHER LIPID MEDIATORS
LA English
DT Review
DE Cytochrome P450 enzymes; Insulin resistance; Metabolic syndrome;
   Polyunsaturated fatty acids
ID SOLUBLE EPOXIDE HYDROLASE; ENDOPLASMIC-RETICULUM STRESS; ACTIVATED
   RECEPTOR-GAMMA; STIMULATED INSULIN-SECRETION; CA2+-ACTIVATED K+
   CHANNELS; EPOXYEICOSATRIENOIC ACIDS; FISH-OIL; EICOSAPENTAENOIC ACID;
   DOCOSAHEXAENOIC ACID; GUT MICROBIOTA
AB Over the last decade, cases of metabolic syndrome and type II diabetes have increased exponentially. Exercise and omega-3 polyunsaturated fatty acid (PUFA)-enriched diets are usually prescribed but no therapy is effectively able to restore the impaired glucose metabolism, hypertension, and atherogenic dyslipidemia encountered by diabetic patients. PUFAs are metabolized by different enzymes into bioactive metabolites with anti- or proinflammatory activity. One important class of PUFA metabolizing enzymes are the cytochrome P450 (CYP) enzymes that can generate a series of bioactive products, many of which have been attributed protective/antiinflammatory and insulin-sensitizing effects in animal models. PUFA epoxides are, however, further metabolized by the soluble epoxide hydrolase (sEH) to fatty acid diols. The biological actions of the latter are less well understood but while low concentrations may be biologically important, higher concentrations of diols derived from linoleic acid and docosahexaenoic acid have been linked with inflammation. One potential application for sEH inhibitors is in the treatment of diabetic retinopathy where sEH expression and activity is elevated as are levels of a diol of docosahexaenoic acid that can induce the destabilization of the retina vasculature.
C1 [dos Santos, Laila R. B.; Fleming, Ingrid] Goethe Univ, Ctr Mol Med, Inst Vasc Signalling, Theodor Stern Kai 7, D-60596 Frankfurt, Germany.
   [dos Santos, Laila R. B.; Fleming, Ingrid] German Ctr Cardiovasc Res DZHK, Partner Site Rhein Main, Frankfurt, Germany.
C3 Goethe University Frankfurt; German Centre for Cardiovascular Research
RP Fleming, I (corresponding author), Goethe Univ, Ctr Mol Med, Inst Vasc Signalling, Theodor Stern Kai 7, D-60596 Frankfurt, Germany.
EM fleming@em.uni-frankfurt.de
RI Fleming, Ingrid/L-1225-2014
OI Fleming, Ingrid/0000-0003-1881-3635
FU Deutsche Forschungsgemeinschaft [SFB 1039/2 A6]; Cardio-Pulmonary
   Institute [EXC 2026, 390649896]
FX This work was supported by the Deutsche Forschungsgemeinschaft (SFB
   1039/2 A6 to I.F. and the Cardio-Pulmonary Institute, EXC 2026, Project
   ID: 390649896).
CR Abraham NG, 2014, HYPERTENSION, V64, P1352, DOI 10.1161/HYPERTENSIONAHA.114.03884
   Achari AE, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18061321
   Ai D, 2007, P NATL ACAD SCI USA, V104, P9018, DOI 10.1073/pnas.0703229104
   Althurwi HN, 2013, BRIT J PHARMACOL, V168, P1794, DOI 10.1111/bph.12066
   Ansari IUH, 2017, ARCH BIOCHEM BIOPHYS, V618, P32, DOI 10.1016/j.abb.2017.02.001
   Arterburn LM, 2006, AM J CLIN NUTR, V83, p1467S, DOI 10.1093/ajcn/83.6.1467S
   Austin S, 2012, J CELL SCI, V125, P4963, DOI 10.1242/jcs.113662
   Barbosa-da-Silva S, 2015, LIFE SCI, V127, P73, DOI 10.1016/j.lfs.2015.02.003
   Barbosa-Sicard E, 2009, J BIOL CHEM, V284, P28156, DOI 10.1074/jbc.M109.054759
   Batchu SN, 2012, CAN J PHYSIOL PHARM, V90, P811, DOI [10.1139/Y2012-082, 10.1139/y2012-082]
   Baynes HW, 2018, ADIPOCYTE, V7, P81, DOI 10.1080/21623945.2018.1443662
   Bettaieb A, 2013, J BIOL CHEM, V288, P14189, DOI 10.1074/jbc.M113.458414
   Bhatt DL, 2019, NEW ENGL J MED, V380, P11, DOI 10.1056/NEJMoa1812792
   Bhatt DL, 2017, CLIN CARDIOL, V40, P138, DOI 10.1002/clc.22692
   Blöcher R, 2016, J MED CHEM, V59, P61, DOI 10.1021/acs.jmedchem.5b01239
   Botros FT, 2002, HYPERTENSION, V39, P639, DOI 10.1161/hy0202.103420
   Bourne RRA, 2013, LANCET GLOB HEALTH, V1, pE339, DOI 10.1016/S2214-109X(13)70113-X
   Burgess A, 2010, HYPERTENSION, V56, P1124, DOI 10.1161/HYPERTENSIONAHA.110.151423
   Caesar R, 2015, CELL METAB, V22, P658, DOI 10.1016/j.cmet.2015.07.026
   Calder PC, 2010, P NUTR SOC, V69, P565, DOI 10.1017/S0029665110000157
   Calviello G, 2013, BIOMED RES INT-UK, V2013, DOI 10.1155/2013/743171
   Campbell WB, 1996, CIRC RES, V78, P415, DOI 10.1161/01.RES.78.3.415
   Campbell WB, 2010, PFLUG ARCH EUR J PHY, V459, P881, DOI 10.1007/s00424-010-0804-6
   Cao J, 2017, AM J PHYSIOL-HEART C, V313, pH368, DOI 10.1152/ajpheart.00093.2017
   Capdevila JH, 2000, J LIPID RES, V41, P163
   CAPDEVILA JH, 1987, BIOCHEM BIOPH RES CO, V146, P638, DOI 10.1016/0006-291X(87)90576-6
   Capozzi ME, 2016, SCI REP-UK, V6, DOI 10.1038/srep39211
   Cardozo AK, 2005, DIABETES, V54, P452, DOI 10.2337/diabetes.54.2.452
   Chan-Ling T, 2018, PROG RETIN EYE RES, V62, P77, DOI 10.1016/j.preteyeres.2017.09.002
   Chen GZ, 2012, AM J PHYSIOL-ENDOC M, V303, pE563, DOI 10.1152/ajpendo.00591.2011
   Chen GZ, 2011, PROSTAG OTH LIPID M, V96, P63, DOI 10.1016/j.prostaglandins.2011.06.009
   Cheranov SY, 2008, BLOOD, V111, P5581, DOI 10.1182/blood-2007-11-126680
   Cnop M, 2005, DIABETES, V54, pS97, DOI 10.2337/diabetes.54.suppl_2.S97
   Cnop M, 2001, DIABETES, V50, P1771, DOI 10.2337/diabetes.50.8.1771
   Cui CX, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0186216
   Cui PH, 2011, BRIT J PHARMACOL, V162, P1143, DOI 10.1111/j.1476-5381.2010.01113.x
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   Das A, 2015, OPHTHALMOLOGY, V122, P1375, DOI 10.1016/j.ophtha.2015.03.024
   De Taeye BM, 2010, OBESITY, V18, P489, DOI 10.1038/oby.2009.227
   Dewey S, 2013, J PROTEOME RES, V12, P3920, DOI 10.1021/pr4004739
   Ding YD, 2014, J PHARMACOL EXP THER, V350, P14, DOI 10.1124/jpet.114.214254
   Donath MY, 2008, DIABETES CARE, V31, pS161, DOI 10.2337/dc08-s243
   Du SC, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0142652
   El-Sikhry HE, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0160380
   Elmarakby AA, 2013, CLIN SCI, V125, P349, DOI 10.1042/CS20130003
   EnayetAllah AE, 2008, J BIOL CHEM, V283, P36592, DOI 10.1074/jbc.M806315200
   FALCK JR, 1983, BIOCHEM BIOPH RES CO, V114, P743, DOI 10.1016/0006-291X(83)90843-4
   Fang X, 2006, AM J PHYSIOL-HEART C, V290, pH55, DOI 10.1152/ajpheart.00427.2005
   Fang X, 2003, PROSTAG OTH LIPID M, V71, P33, DOI 10.1016/S0090-6980(03)00002-9
   Fares H, 2014, CURR ATHEROSCLER REP, V16, DOI 10.1007/s11883-013-0389-6
   Fei N, 2013, ISME J, V7, P880, DOI 10.1038/ismej.2012.153
   Ferreira MR, 2013, PROSTAG LEUKOTR ESS, V89, P31, DOI 10.1016/j.plefa.2013.04.006
   Fichtlscherer S, 2004, CIRCULATION, V109, P178, DOI 10.1161/01.CIR.0000105763.51286.7F
   Fischer R, 2014, J LIPID RES, V55, P1150, DOI 10.1194/jlr.M047357
   Fisslthaler B, 1999, NATURE, V401, P493, DOI 10.1038/46816
   Fleming I, 2001, CIRC RES, V88, P44, DOI 10.1161/01.RES.88.1.44
   Fleming I, 2016, VASC PHARMACOL, V86, P31, DOI 10.1016/j.vph.2016.03.001
   Fleming I, 2014, PHARMACOL REV, V66, P1106, DOI 10.1124/pr.113.007781
   FLIESLER SJ, 1983, PROG LIPID RES, V22, P79
   Frömel T, 2012, P NATL ACAD SCI USA, V109, P9995, DOI 10.1073/pnas.1206493109
   Fu ZJ, 2015, AM J CLIN NUTR, V101, P879, DOI 10.3945/ajcn.114.099291
   Furuhashi M, 2007, NATURE, V447, P959, DOI 10.1038/nature05844
   Furuhashi M, 2014, CLIN MED INSIGHTS-CA, V8, P23, DOI 10.4137/CMC.S17067
   Gangadhariah MH, 2017, DIABETOLOGIA, V60, P1066, DOI 10.1007/s00125-017-4260-0
   Gong Y, 2016, ARTERIOSCL THROM VAS, V36, P1919, DOI 10.1161/ATVBAHA.116.307558
   Gray B, 2013, EUR J CLIN NUTR, V67, P1234, DOI 10.1038/ejcn.2013.197
   Grey A, 2014, JAMA INTERN MED, V174, P460, DOI 10.1001/jamainternmed.2013.12765
   Guglielmino K, 2012, AM J PHYSIOL-HEART C, V303, pH853, DOI 10.1152/ajpheart.00154.2012
   Guo SD, 2014, J ENDOCRINOL, V220, pT1, DOI 10.1530/JOE-13-0327
   Hård AL, 2013, SEMIN FETAL NEONAT M, V18, P136, DOI 10.1016/j.siny.2013.01.006
   Harris TR, 2015, TOXICOL APPL PHARM, V286, P102, DOI 10.1016/j.taap.2015.03.022
   Harris TR, 2013, GENE, V526, P61, DOI 10.1016/j.gene.2013.05.008
   Henquin JC, 2000, DIABETES, V49, P1751, DOI 10.2337/diabetes.49.11.1751
   Hesselink MKC, 2016, NAT REV ENDOCRINOL, V12, P633, DOI 10.1038/nrendo.2016.104
   Hu J, 2019, J CLIN INVEST, V129, P5204, DOI 10.1172/JCI123835
   Hu J, 2017, PROSTAG OTH LIPID M, V133, P93, DOI 10.1016/j.prostaglandins.2017.04.002
   Hu J, 2017, NATURE, V552, P248, DOI 10.1038/nature25013
   Huang H, 2007, AM J PHYSIOL-RENAL, V293, pF342, DOI 10.1152/ajprenal.00004.2007
   Huang XY, 2017, BIOCHEM BIOPH RES CO, V490, P123, DOI 10.1016/j.bbrc.2017.06.007
   Imig JD, 2016, ADV PHARMACOL, V77, P105, DOI 10.1016/bs.apha.2016.04.003
   Imig JD, 2002, HYPERTENSION, V39, P690, DOI 10.1161/hy0202.103788
   Imig JD, 2012, PHYSIOL REV, V92, P101, DOI 10.1152/physrev.00021.2011
   Imig JD, 2009, NAT REV DRUG DISCOV, V8, P794, DOI 10.1038/nrd2875
   Islam O, 2017, CARDIOVASC THER, V35, DOI 10.1111/1755-5922.12259
   Iyer A, 2012, EXP DIABETES RES, DOI 10.1155/2012/758614
   Jia GH, 2018, DIABETOLOGIA, V61, P21, DOI 10.1007/s00125-017-4390-4
   Jouihan SA, 2013, J CEREBR BLOOD F MET, V33, P1650, DOI 10.1038/jcbfm.2013.130
   Joukov V, 1996, EMBO J, V15, P290
   Jump DB, 2012, J LIPID RES, V53, P2525, DOI 10.1194/jlr.R027904
   KARARA A, 1991, J BIOL CHEM, V266, P7561
   Katragadda D, 2009, J MOL CELL CARDIOL, V46, P867, DOI 10.1016/j.yjmcc.2009.02.028
   Kim DH, 2010, STEM CELLS DEV, V19, P1863, DOI 10.1089/scd.2010.0098
   Kitson AP, 2012, PROSTAG LEUKOTR ESS, V87, P1, DOI 10.1016/j.plefa.2012.06.001
   Klaassen I, 2013, PROG RETIN EYE RES, V34, P19, DOI 10.1016/j.preteyeres.2013.02.001
   Klett EL, 2013, J BIOL CHEM, V288, P21618, DOI 10.1074/jbc.M113.481077
   Korbecki J, 2014, ACTA BIOCHIM POL, V61, P639
   Kromhout D, 2012, EUR HEART J, V33, P436, DOI 10.1093/eurheartj/ehr362
   Kumar KV, 2000, CLIN CHIM ACTA, V298, P111, DOI 10.1016/S0009-8981(00)00264-3
   Lahvic JL, 2018, P NATL ACAD SCI USA, V115, P9252, DOI 10.1073/pnas.1806077115
   Lapillonne A, 2016, ANN NUTR METAB, V69, P36, DOI 10.1159/000448265
   Lee HC, 2019, FOOD FUNCT, V10, P786, DOI 10.1039/c8fo02423e
   Lee SM, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/712949
   Li R, 2015, AM J PHYSIOL-ENDOC M, V308, pE270, DOI 10.1152/ajpendo.00118.2014
   Liu HQ, 2013, NUTR RES, V33, P849, DOI 10.1016/j.nutres.2013.07.004
   Liu L, 2011, J PHARMACOL EXP THER, V339, P451, DOI 10.1124/jpet.111.180505
   Liu PY, 2007, ATHEROSCLEROSIS, V195, P199, DOI 10.1016/j.atherosclerosis.2006.11.001
   Liu XH, 2017, PROSTAG OTH LIPID M, V132, P31, DOI 10.1016/j.prostaglandins.2016.09.002
   Liu Y, 2005, P NATL ACAD SCI USA, V102, P16747, DOI 10.1073/pnas.0508081102
   Liu Y, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039165
   Loot AE, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046065
   Lopez-Toledano MA, 2017, CLIN THER, V39, P581, DOI 10.1016/j.clinthera.2017.01.020
   López-Vicario C, 2016, EUR J PHARMACOL, V785, P133, DOI 10.1016/j.ejphar.2015.03.092
   López-Vicario C, 2015, P NATL ACAD SCI USA, V112, P536, DOI 10.1073/pnas.1422590112
   López-Vicario C, 2014, GUT, V63, P344, DOI 10.1136/gutjnl-2012-303179
   Lou DJ, 2014, J DIABETES COMPLICAT, V28, P711, DOI 10.1016/j.jdiacomp.2014.04.008
   Lovegrove JA, 2013, CURR OPIN CLIN NUTR, V16, P162, DOI 10.1097/MCO.0b013e32835c5f29
   Luo PC, 2011, PROSTAG OTH LIPID M, V95, P1, DOI 10.1016/j.prostaglandins.2011.06.001
   Luria A, 2011, P NATL ACAD SCI USA, V108, P9038, DOI 10.1073/pnas.1103482108
   Luria A, 2009, AM J PHYSIOL-ENDOC M, V297, pE375, DOI 10.1152/ajpendo.00131.2009
   Mangels N, 2016, PROSTAG OTH LIPID M, V125, P30, DOI 10.1016/j.prostaglandins.2016.05.003
   Mason RP, 2017, BIOCHEM BIOPH RES CO, V483, P425, DOI 10.1016/j.bbrc.2016.12.127
   Michaelis UR, 2006, PHARMACOL THERAPEUT, V111, P584, DOI 10.1016/j.pharmthera.2005.11.003
   Moghaddam MF, 1997, NAT MED, V3, P562, DOI 10.1038/nm0597-562
   Morciano G, 2017, ADV EXP MED BIOL, V982, P169, DOI 10.1007/978-3-319-55330-6_9
   Mori TA, 2006, CLIN EXP PHARMACOL P, V33, P842, DOI 10.1111/j.1440-1681.2006.04451.x
   Morin C, 2010, AM J RESP CELL MOL, V43, P564, DOI 10.1165/rcmb.2009-0155OC
   Nakamura T, 1997, J MASS SPECTROM, V32, P888, DOI 10.1002/(SICI)1096-9888(199708)32:8<888::AID-JMS548>3.0.CO;2-W
   Node K, 1999, SCIENCE, V285, P1276, DOI 10.1126/science.285.5431.1276
   Nording ML, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076575
   Norris GH, 2016, J NUTR BIOCHEM, V30, P93, DOI 10.1016/j.jnutbio.2015.12.003
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Ohshima K, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048387
   Ohta M, 2012, BIOCHEM BIOPH RES CO, V424, P301, DOI 10.1016/j.bbrc.2012.06.111
   Pang W, 2011, CLIN EXP PHARMACOL P, V38, P358, DOI 10.1111/j.1440-1681.2011.05492.x
   Pawlik D, 2014, JPEN-PARENTER ENTER, V38, P711, DOI 10.1177/0148607113499373
   Pinel A, 2014, J PHYSIOL BIOCHEM, V70, P647, DOI 10.1007/s13105-013-0303-2
   Prentki M, 2006, J CLIN INVEST, V116, P1802, DOI 10.1172/JCI29103
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Quinlan GJ, 1996, CRIT CARE MED, V24, P241, DOI 10.1097/00003246-199602000-00010
   Randriamboavonjy V, 2008, CIRCULATION, V117, P52, DOI 10.1161/CIRCULATIONAHA.107.719807
   Randriamboavonjy V, 2017, BASIC RES CARDIOL, V112, DOI 10.1007/s00395-016-0596-8
   Randriamboavonjy V, 2012, BLOOD, V120, P415, DOI 10.1182/blood-2011-12-399980
   Rauch B, 2010, CIRCULATION, V122, P2152, DOI 10.1161/CIRCULATIONAHA.110.948562
   Rivera JC, 2017, J NEUROINFLAMM, V14, DOI 10.1186/s12974-017-0943-1
   Robertson RC, 2017, BRIT J NUTR, V118, P959, DOI [10.1017/S0007114517002999, 10.1017/s0007114517002999]
   Robinson R, 2012, DIS MODEL MECH, V5, P444, DOI 10.1242/dmm.009597
   Rodriguez M, 2006, ANN NY ACAD SCI, V1079, P130, DOI 10.1196/annals.1375.019
   Romashko M, 2016, TRENDS PHARMACOL SCI, V37, P945, DOI 10.1016/j.tips.2016.08.001
   Roth M, 2009, AM J RESP CRIT CARE, V180, P353, DOI 10.1164/rccm.200806-848OC
   Sacerdoti D, 2007, PROSTAG OTH LIPID M, V82, P155, DOI 10.1016/j.prostaglandins.2006.07.001
   Sala A, 2018, BIOCHEM PHARMACOL, V158, P161, DOI 10.1016/j.bcp.2018.10.007
   Santoro N, 2014, ANTIOXID REDOX SIGN, V20, P383, DOI 10.1089/ars.2013.5466
   Santos LRB, 2011, ENDOCRINOLOGY, V152, P3614, DOI 10.1210/en.2011-0127
   Scarpulla RC, 2011, BBA-MOL CELL RES, V1813, P1269, DOI 10.1016/j.bbamcr.2010.09.019
   Schuchardt JP, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-145
   Serhan CN, 2018, J CLIN INVEST, V128, P2657, DOI 10.1172/JCI97943
   Shah RD, 2005, CELL PHYSIOL BIOCHEM, V15, P41, DOI 10.1159/000083637
   Shao Z, 2014, ARTERIOSCL THROM VAS, V34, P581, DOI 10.1161/ATVBAHA.113.302927
   Shen L, 2015, ATHEROSCLEROSIS, V239, P557, DOI 10.1016/j.atherosclerosis.2015.02.014
   Shen L, 2014, BIOL CHEM, V395, P443, DOI 10.1515/hsz-2013-0251
   SHIVACHAR AC, 1995, J NEUROCHEM, V65, P338
   Veiga FM, 2017, BIOCHIMIE, V140, P106, DOI 10.1016/j.biochi.2017.07.003
   Singh SP, 2016, J NUTR METAB, V2016, DOI 10.1155/2016/9039754
   Skepner JE, 2011, PROSTAG OTH LIPID M, V94, P3, DOI 10.1016/j.prostaglandins.2010.10.002
   Soyal S, 2006, DIABETOLOGIA, V49, P1477, DOI 10.1007/s00125-006-0268-6
   Spector AA, 2015, BBA-MOL CELL BIOL L, V1851, P356, DOI 10.1016/j.bbalip.2014.07.020
   Spiecker M, 2004, CIRCULATION, V110, P2132, DOI 10.1161/01.CIR.0000143832.91812.60
   Sternberg P, 2018, AM J OPHTHALMOL, V186, pXXIII, DOI 10.1016/j.ajo.2017.10.027
   Suez J., 2016, CLIN NUTR EXPT, V6, P59, DOI DOI 10.1016/J.YCLNEX.2016.01.001
   Sulaiman RS, 2018, ACS CHEM BIOL, V13, P45, DOI 10.1021/acschembio.7b00854
   Sulaiman RS, 2016, SCI REP-UK, V6, DOI 10.1038/srep25509
   Suzuki S, 2008, J PHARMACOL SCI, V108, P79, DOI 10.1254/jphs.08122FP
   Tanaka H, 2008, BBA-GENE REGUL MECH, V1779, P17, DOI 10.1016/j.bbagrm.2007.11.005
   Theken KN, 2012, ATHEROSCLEROSIS, V222, P530, DOI 10.1016/j.atherosclerosis.2012.03.022
   Theken KN, 2012, AM J PHYSIOL-ENDOC M, V302, pE500, DOI 10.1152/ajpendo.00370.2011
   THOMAS H, 1989, BIOCHEM PHARMACOL, V38, P4291, DOI 10.1016/0006-2952(89)90528-5
   Thompson DA, 2007, J BIOSCIENCES, V32, P279, DOI 10.1007/s12038-007-0028-x
   Tiyerili V, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-30
   Tubbs E, 2014, DIABETES, V63, P3279, DOI 10.2337/db13-1751
   Van Gaal LF, 2006, NATURE, V444, P875, DOI 10.1038/nature05487
   VanRollins M, 1996, J BIOL CHEM, V271, P14001, DOI 10.1074/jbc.271.24.14001
   Vasconez AE, 2019, ACTA PHYSIOL, V225, DOI 10.1111/apha.13168
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Waldman M, 2016, STEM CELLS DEV, V25, P1084, DOI 10.1089/scd.2016.0072
   Wang CP, 2010, EXP CLIN ENDOCR DIAB, V118, P346, DOI 10.1055/s-0029-1243604
   Wang CC, 2006, AM J CLIN NUTR, V84, P5, DOI 10.1093/ajcn/84.1.5
   Wang J, 2015, MOL NUTR FOOD RES, V59, P1791, DOI 10.1002/mnfr.201500299
   Wang MH, 2003, HYPERTENSION, V42, P594, DOI 10.1161/01.HYP.0000090123.55365.BA
   Wang XX, 2014, MOL PHARMACOL, V85, P105, DOI 10.1124/mol.113.087122
   Webler AC, 2008, AM J PHYSIOL-CELL PH, V295, pC1292, DOI 10.1152/ajpcell.00230.2008
   Wei D, 2010, DIABETES, V59, P471, DOI 10.2337/db09-0284
   Weintraub NL, 1999, AM J PHYSIOL-HEART C, V277, pH2098, DOI 10.1152/ajpheart.1999.277.5.H2098
   Wells MA, 2016, PROSTAG OTH LIPID M, V125, P19, DOI 10.1016/j.prostaglandins.2016.07.002
   Widstrom RL, 2003, BIOCHEMISTRY-US, V42, P11762, DOI 10.1021/bi034971d
   Williams JA, 2012, BIOPHYS J, V103, P228, DOI 10.1016/j.bpj.2012.06.016
   Xu D, 2006, P NATL ACAD SCI USA, V103, P18733, DOI 10.1073/pnas.0609158103
   Xu WH, 2002, SCIENCE, V298, P1029, DOI 10.1126/science.1074360
   Xu XZ, 2013, ENDOCRINOLOGY, V154, P1743, DOI 10.1210/en.2012-2012
   Xu XZ, 2010, DIABETES, V59, P997, DOI 10.2337/db09-1241
   Yang J, 2017, J NUTR BIOCHEM, V49, P8, DOI 10.1016/j.jnutbio.2017.07.006
   Yang SL, 2009, ARCH BIOCHEM BIOPHYS, V489, P82, DOI 10.1016/j.abb.2009.05.006
   Yates CM, 2014, PHARMACOL THERAPEUT, V141, P272, DOI 10.1016/j.pharmthera.2013.10.010
   Yau JWY, 2012, DIABETES CARE, V35, P556, DOI 10.2337/dc11-1909
   Yokoyama M, 2007, LANCET, V369, P1090, DOI 10.1016/S0140-6736(07)60527-3
   Zarain-Herzberg A, 2014, CELL CALCIUM, V56, P302, DOI 10.1016/j.ceca.2014.09.005
   Zhang GD, 2013, P NATL ACAD SCI USA, V110, P6530, DOI 10.1073/pnas.1304321110
   Zhang SS, 2015, OBESITY, V23, P1401, DOI 10.1002/oby.21115
NR 207
TC 22
Z9 23
U1 2
U2 20
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1098-8823
EI 2212-196X
J9 PROSTAG OTH LIPID M
JI Prostaglandins Other Lipid Mediat.
PD JUN
PY 2020
VL 148
AR 106407
DI 10.1016/j.prostaglandins.2019.106407
PG 14
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA LP6LK
UT WOS:000534430200008
PM 31899373
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Calcaterra, V
   Biganzoli, G
   Ferraro, S
   Mari, A
   Mandelli, A
   Fabiano, V
   Carlucci, P
   Pelizzo, G
   Zoia, E
   Lanfranchi, G
   Castaldi, S
   Boracchi, P
   Biganzoli, E
   Zuccotti, G
AF Calcaterra, Valeria
   Biganzoli, Giacomo
   Ferraro, Simona
   Mari, Alessandra
   Mandelli, Anna
   Fabiano, Valentina
   Carlucci, Patrizia
   Pelizzo, Gloria
   Zoia, Elena
   Lanfranchi, Giulia
   Castaldi, Silvana
   Boracchi, Patrizia
   Biganzoli, Elia
   Zuccotti, Gianvincenzo
TI Thyroid Function and Metabolic Syndrome in Children and Adolescents with
   Neuromotor Disability
SO CHILDREN-BASEL
LA English
DT Article
DE thyroid function; thyroid hormones; disability; neuromotor impairment;
   metabolic syndrome; children
ID HORMONES; STRESS; NERVE; DISORDERS; PROLACTIN; MODEL
AB Thyroid function plays a crucial role in nervous system integrity and metabolic homeostasis. We evaluated the pattern of TSH, FT4 and FT3 release in children with neuromotor impairment (NI) in relationship with metabolic syndrome (MS). We enrolled 55 patients with NI and 30 controls. Clinical parameters, thyroid function and MS presence were recorded. Principal component analysis (PCA), cluster analysis, and logistic regression models were performed. MS was detected in 54.5% of patients. Four clusters were identified: the first one included only controls and, contrasting with cluster 4, was exclusively characterized by children with disability and MS. This latter showed increased FT4 and FT3 and decreased TSH levels. Cluster 2, characterized by disability without MS showed high FT4 and FT3, whereas cluster 3 with low FT4 and FT3 mainly included disability (90%) and showed prevalent MS (57%). The association between TSH and NI is represented by a U-shape structure. The TSH, FT3 and FT4 release patterns may reflect thyrotropic adaptation, allostatic response and compensatory mechanisms. These mechanisms, found in both MS and disability, show that the odds of having a condition of NI with or without MS increase as the TSH values deviate, in both directions, from a value of 2.5 mLU/mL.
C1 [Calcaterra, Valeria] Univ Pavia, Dept Internal Med, I-27100 Pavia, Italy.
   [Calcaterra, Valeria; Mari, Alessandra; Fabiano, Valentina; Carlucci, Patrizia; Zuccotti, Gianvincenzo] V Buzzi Childrens Hosp, Pediat Dept, I-20154 Milan, Italy.
   [Biganzoli, Giacomo; Boracchi, Patrizia; Biganzoli, Elia] Univ Milan, Univ Hosp, Dept Biomed & Clin Sci, Med Stat Unit, I-20157 Milan, Italy.
   [Ferraro, Simona] Luigi Sacco Univ Hosp, Endocrinol Lab Unit, I-20157 Milan, Italy.
   [Mandelli, Anna; Zoia, Elena] V Buzzi Childrens Hosp, Intens Care Unit, I-20154 Milan, Italy.
   [Fabiano, Valentina; Pelizzo, Gloria; Zuccotti, Gianvincenzo] Univ Milan, Dept Biomed & Clin Sci, I-20157 Milan, Italy.
   [Pelizzo, Gloria; Lanfranchi, Giulia] V Buzzi Childrens Hosp, Pediat Surg Dept, I-20154 Milan, Italy.
   [Castaldi, Silvana] Univ Milan, Dept Biomed Sci Hlth, I-20157 Milan, Italy.
   [Castaldi, Silvana] Fdn IRCCS Ca Granda Osped Maggiore Policlin, I-20122 Milan, Italy.
C3 University of Pavia; University of Milan; University of Milan; Luigi
   Sacco Hospital; University of Milan; University of Milan; IRCCS Ca
   Granda Ospedale Maggiore Policlinico
RP Calcaterra, V (corresponding author), Univ Pavia, Dept Internal Med, I-27100 Pavia, Italy.; Calcaterra, V (corresponding author), V Buzzi Childrens Hosp, Pediat Dept, I-20154 Milan, Italy.
EM valeria.calcaterra@unipv.it
RI Biganzoli, Elia/J-1678-2012; Calcaterra, Valeria/AAB-7563-2022; Ferraro,
   Simona/AAC-3514-2022; Patrizia, Boracchi/AAB-8851-2019; Lanfranchi,
   Giulia/MIO-8682-2025; FABIANO, VALENTINA/H-8818-2017; Zuccotti,
   Gianvincenzo/H-8572-2017; Castaldi, Silvana/L-1493-2016
OI FABIANO, VALENTINA/0000-0001-6449-1724; Lanfranchi,
   Giulia/0009-0000-2749-0896; Biganzoli, Elia/0000-0003-1202-5873;
   Zuccotti, Gianvincenzo/0000-0002-2795-9874; CALCATERRA,
   VALERIA/0000-0002-2137-5974; Mari, Alessandra/0000-0001-7418-1447;
   Castaldi, Silvana/0000-0003-1716-6624
CR Ahmed OM, 2008, INT J DEV NEUROSCI, V26, P147, DOI 10.1016/j.ijdevneu.2007.09.011
   [Anonymous], WHO CHILD GROWTH STA
   Barakat-Walter I, 2018, NEURAL REGEN RES, V13, P599, DOI 10.4103/1673-5374.230274
   BARAKATWALTER I, 1993, EUR J NEUROSCI, V5, P319, DOI 10.1111/j.1460-9568.1993.tb00499.x
   BERENBERG RA, 1977, EXP NEUROL, V57, P349, DOI 10.1016/0014-4886(77)90071-1
   Calcaterra V, 2022, J CLIN MED, V11, DOI 10.3390/jcm11071856
   Calcaterra V, 2021, CHILDREN-BASEL, V8, DOI 10.3390/children8030186
   Calcaterra V, 2017, HORM RES PAEDIAT, V88, P224, DOI 10.1159/000477906
   Chatzitomaris A, 2017, FRONT ENDOCRINOL, V8, DOI 10.3389/fendo.2017.00163
   Chen XL, 2021, J CLIN ENDOCR METAB, V106, pE1221, DOI 10.1210/clinem/dgaa900
   Chrousos GP, 2009, NAT REV ENDOCRINOL, V5, P374, DOI 10.1038/nrendo.2009.106
   Courtin F, 2005, THYROID, V15, P931, DOI 10.1089/thy.2005.15.931
   d'Annunzio Giuseppe, 2009, Acta Biomed, V80, P21
   D'Intino G, 2011, J NEUROENDOCRINOL, V23, P778, DOI 10.1111/j.1365-2826.2011.02181.x
   Franklin RJM, 1996, GLIA, V17, P217, DOI 10.1002/(SICI)1098-1136(199607)17:3<217::AID-GLIA4>3.0.CO;2-Y
   Guarner-Lans V, 2011, EXP GERONTOL, V46, P517, DOI 10.1016/j.exger.2011.02.007
   Koulouri O, 2013, BEST PRACT RES CL EN, V27, P745, DOI 10.1016/j.beem.2013.10.003
   Lambadiari V, 2011, ENDOCRINE, V39, P28, DOI 10.1007/s12020-010-9408-3
   Lennartsson AK, 2011, PSYCHONEUROENDOCRINO, V36, P1530, DOI 10.1016/j.psyneuen.2011.04.007
   Liu J, 2021, ENDOCR PRACT, V27, P728, DOI 10.1016/j.eprac.2021.01.002
   MARSHALL WA, 1970, ARCH DIS CHILD, V45, P13, DOI 10.1136/adc.45.239.13
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Pelizzo G, 2017, J PEDIATR ENDOCR MET, V30, P289, DOI 10.1515/jpem-2016-0369
   REIER PJ, 1972, BRAIN RES, V41, P263, DOI 10.1016/0006-8993(72)90502-1
   Shin KA, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000028409
   Souza AD, 2011, EUR J ENDOCRINOL, V165, P11, DOI 10.1530/EJE-11-0261
   Teixeira PDD, 2020, THER ADV ENDOCRINOL, V11, DOI 10.1177/2042018820917869
   Tropeano A, 2023, J ENDOCRINOL INVEST, V46, P285, DOI 10.1007/s40618-022-01899-z
   Tropeano A, 2021, EUR J ENDOCRINOL, V185, P265, DOI 10.1530/EJE-21-0238
   van Dijk G, 2015, FRONT NEUROSCI-SWITZ, V9, DOI 10.3389/fnins.2015.00173
   Videira-Silva A, 2017, EUR J PEDIATR, V176, P655, DOI 10.1007/s00431-017-2892-1
   Waring AC, 2012, CLIN ENDOCRINOL, V76, P911, DOI 10.1111/j.1365-2265.2011.04328.x
NR 32
TC 6
Z9 6
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9067
J9 CHILDREN-BASEL
JI Children-Basel
PD OCT
PY 2022
VL 9
IS 10
AR 1531
DI 10.3390/children9101531
PG 20
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 5O5FM
UT WOS:000872499100001
PM 36291467
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nurcahyanti, ADR
   Cokro, F
   Wulanjati, MP
   Mahmoud, MF
   Wink, M
   Sobeh, M
AF Nurcahyanti, Agustina Dwi Retno
   Cokro, Fonny
   Wulanjati, Martha P.
   Mahmoud, Mona F.
   Wink, Michael
   Sobeh, Mansour
TI Curcuminoids for Metabolic Syndrome: Meta-Analysis Evidences Toward
   Personalized Prevention and Treatment Management
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE metabolic syndrome; curcumin; curcuminoid; turmeric; personalized
   treatment; gut microbiome; meta-analysis; randomized controlled trial
ID FATTY LIVER-DISEASE; TYPE-2 DIABETES-MELLITUS; C-REACTIVE PROTEIN;
   NF-KAPPA-B; OXIDATIVE STRESS; GUT MICROBIOTA; INSULIN-RESISTANCE;
   CURCUMA-LONGA; ANTIOXIDANT BALANCE; PHYTOSOMAL CURCUMIN
AB The metabolic syndrome (MS) is a multifactorial syndrome associated with a significant economic burden and healthcare costs. MS management often requires multiple treatments (polydrug) to ameliorate conditions such as diabetes mellitus, insulin resistance, obesity, cardiovascular diseases, hypertension, and non-alcoholic fatty liver disease (NAFLD). However, various therapeutics and possible drug-drug interactions may also increase the risk of MS by altering lipid and glucose metabolism and promoting weight gain. In addition, the medications cause side effects such as nausea, flatulence, bloating, insomnia, restlessness, asthenia, palpitations, cardiac arrhythmias, dizziness, and blurred vision. Therefore, is important to identify and develop new safe and effective agents based on a multi-target approach to treat and manage MS. Natural products, such as curcumin, have multi-modalities to simultaneously target several factors involved in the development of MS. This review discusses the recent preclinical and clinical findings, and up-to-date meta-analysis from Randomized Controlled Trials regarding the effects of curcumin on MS, as well as the metabonomics and a pharma-metabolomics outlook considering curcumin metabolites, the gut microbiome, and environment for a complementary personalized prevention and treatment for MS management.
C1 [Nurcahyanti, Agustina Dwi Retno; Cokro, Fonny] Atma Jaya Catholic Univ Indonesia, Sch Med & Hlth Sci, Dept Pharm, Jakarta, Indonesia.
   [Wulanjati, Martha P.] Natl Res & Innovat Agcy BRIN, Res Div Nat Prod Technol BPTBA, Yogyakarta, Indonesia.
   [Mahmoud, Mona F.] Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig, Egypt.
   [Wink, Michael] Heidelberg Univ, Inst Pharm & Mol Biotechnol IPMB, Heidelberg, Germany.
   [Sobeh, Mansour] Mohammed VI Polytech Univ, AgroBioSci Dept, Ben Guerir, Morocco.
C3 University Katolik Indonesia Atma Jaya; National Research & Innovation
   Agency of Indonesia (BRIN); Egyptian Knowledge Bank (EKB); Zagazig
   University; Ruprecht Karls University Heidelberg; Mohammed VI
   Polytechnic University
RP Nurcahyanti, ADR (corresponding author), Atma Jaya Catholic Univ Indonesia, Sch Med & Hlth Sci, Dept Pharm, Jakarta, Indonesia.; Sobeh, M (corresponding author), Mohammed VI Polytech Univ, AgroBioSci Dept, Ben Guerir, Morocco.
EM adr.nurcahyanti@atmajaya.ac.id; mansour.sobeh@um6p.ma
RI Mahmoud, Mona/Q-8851-2019; Sobeh, Mansour/AAY-6521-2021; Nurcahyanti,
   Agustina/ABY-9586-2022; Wink, Michael/E-3803-2012
OI Cokro, Fonny/0000-0002-9810-1402; Sobeh, Mansour/0000-0002-2719-8534;
   Wink, Michael/0000-0002-7875-4510
CR Aggarwal BB, 2015, MOLECULES, V20, P185, DOI 10.3390/molecules20010185
   Aggarwal BB, 2010, ANNU REV NUTR, V30, P173, DOI 10.1146/annurev.nutr.012809.104755
   Aguilar F, 2010, EFSA J, V8, DOI 10.2903/j.efsa.2010.1679
   Akbari M, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.00649
   Al-Jenoobi FI, 2015, EUR J DRUG METAB PH, V40, P61, DOI 10.1007/s13318-014-0180-2
   Alamdari DH, 2008, CLIN BIOCHEM, V41, P375, DOI 10.1016/j.clinbiochem.2007.12.008
   Altobelli E, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020404
   Anand P, 2007, MOL PHARMACEUT, V4, P807, DOI 10.1021/mp700113r
   Anhê FF, 2015, CURR OBES REP, V4, P389, DOI 10.1007/s13679-015-0172-9
   Antcliffe D, 2016, CRIT CARE, V20, DOI 10.1186/s13054-016-1222-8
   Armutcu F, 2008, CLIN CHEM LAB MED, V46, P785, DOI 10.1515/CCLM.2008.166
   Arruda AP, 2014, NAT MED, V20, P1427, DOI 10.1038/nm.3735
   Asai A, 2000, LIFE SCI, V67, P2785, DOI 10.1016/S0024-3205(00)00868-7
   Azhdari M, 2019, PHYTOTHER RES, V33, P1289, DOI 10.1002/ptr.6323
   Bäckhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Bai XJ, 2018, PHARMACOL REP, V70, P60, DOI 10.1016/j.pharep.2017.07.014
   Basnet P, 2011, MOLECULES, V16, P4567, DOI 10.3390/molecules16064567
   Bastard JP, 2006, EUR CYTOKINE NETW, V17, P4
   Bateni Z, 2021, PHYTOTHER RES, V35, P3945, DOI 10.1002/ptr.7109
   Baziar N, 2020, PHYTOTHER RES, V34, P464, DOI 10.1002/ptr.6542
   Bindels LB, 2015, NAT REV GASTRO HEPAT, V12, P303, DOI 10.1038/nrgastro.2015.47
   Bradford PG, 2013, BIOFACTORS, V39, P78, DOI 10.1002/biof.1074
   Bulboaca A, 2016, IRAN J BASIC MED SCI, V19, P585
   Burgos-Morón E, 2010, INT J CANCER, V126, P1771, DOI 10.1002/ijc.24967
   Campbell MS, 2018, CRIT REV FOOD SCI, V58, P2790, DOI 10.1080/10408398.2017.1341865
   Cani PD, 2013, CURR OPIN PHARMACOL, V13, P935, DOI 10.1016/j.coph.2013.09.008
   Cerletti C, 2020, BRIT J NUTR, V123, P190, DOI 10.1017/S0007114519002484
   Chashmniam S, 2019, EUR J CLIN NUTR, V73, P1224, DOI 10.1038/s41430-018-0386-5
   Chaudhury A, 2017, FRONT ENDOCRINOL, V8, DOI 10.3389/fendo.2017.00006
   Chen Y, 2010, ANN PHARMACOTHER, V44, P1038, DOI 10.1345/aph.1M533
   Chien YJ, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020684
   Chuengsamarn S, 2012, DIABETES CARE, V35, P2121, DOI 10.2337/dc12-0116
   Chukwuma CI, 2019, J ETHNOPHARMACOL, V235, P329, DOI 10.1016/j.jep.2019.02.024
   Chung CC, 2014, ACTA CARDIOL SIN, V30, P474
   Cicero AFG, 2020, EUR J NUTR, V59, P477, DOI 10.1007/s00394-019-01916-7
   Cicero AFG, 2018, NUTRIENTS, V10, DOI 10.3390/nu10091153
   Cicero AFG, 2016, PHYTOMEDICINE, V23, P1113, DOI 10.1016/j.phymed.2015.10.011
   Clark CCT, 2019, DIABETES METAB SYND, V13, P2819, DOI 10.1016/j.dsx.2019.07.045
   clinicaltrials, About us
   Cornier MA, 2008, ENDOCR REV, V29, P777, DOI 10.1210/er.2008-0024
   Cunningham M, 2021, TRENDS MICROBIOL, V29, P667, DOI 10.1016/j.tim.2021.01.003
   Dei Cas M, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092147
   Delzenne NM, 2011, NAT REV ENDOCRINOL, V7, P639, DOI 10.1038/nrendo.2011.126
   Di Pierro F, 2015, EUR REV MED PHARMACO, V19, P4195
   Dileep KV, 2011, INTERDISCIP SCI, V3, P189, DOI 10.1007/s12539-011-0090-9
   du Preez R, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071542
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Faiz-ul Hassan, 2019, FRONT GENET, V10, DOI 10.3389/fgene.2019.00514
   Feng D, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-40
   Ferguson JJA, 2021, NUTR REV, V79, P1043, DOI 10.1093/nutrit/nuaa114
   Foss MT, 2001, PHARMACOTHERAPY, V21, P1422, DOI 10.1592/phco.21.17.1422.34430
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gaggini M, 2013, NUTRIENTS, V5, P1544, DOI 10.3390/nu5051544
   Garg R, 2021, EUR J PHARMACOL, V901, DOI 10.1016/j.ejphar.2021.174079
   Ghazimoradi M, 2017, PHYTOTHER RES, V31, P1715, DOI 10.1002/ptr.5899
   Gheibi S, 2019, BIOMED PHARMACOTHER, V115, DOI 10.1016/j.biopha.2019.108938
   Ghosh SS, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0108577
   Goel A, 2008, BIOCHEM PHARMACOL, V75, P787, DOI 10.1016/j.bcp.2007.08.016
   Gorabi AM, 2021, CYTOKINE, V143, DOI 10.1016/j.cyto.2021.155541
   Guo SD, 2014, J ENDOCRINOL, V220, pT1, DOI 10.1530/JOE-13-0327
   Hadi A, 2019, PHARMACOL RES, V150, DOI 10.1016/j.phrs.2019.104505
   Hakkola J, 2020, ARCH TOXICOL, V94, P3671, DOI 10.1007/s00204-020-02936-7
   Hariri M, 2020, COMPLEMENT THER MED, V51, DOI 10.1016/j.ctim.2020.102447
   Hassaninasab A, 2011, P NATL ACAD SCI USA, V108, P6615, DOI 10.1073/pnas.1016217108
   Higgins J, 2012, DRUG DISCOV TODAY, V17, P828, DOI 10.1016/j.drudis.2012.03.016
   Hildebrandt MA, 2009, GASTROENTEROLOGY, V137, P1716, DOI 10.1053/j.gastro.2009.08.042
   Hills RD, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071613
   Hodaei H, 2019, DIABETOL METAB SYNDR, V11, DOI 10.1186/s13098-019-0437-7
   HOLDER GM, 1978, XENOBIOTICA, V8, P761, DOI 10.3109/00498257809069589
   Holmes E, 2008, CELL, V134, P714, DOI 10.1016/j.cell.2008.08.026
   Hotamisligil GS, 2017, NATURE, V542, P177, DOI 10.1038/nature21363
   Hsieh YW, 2014, SCI REP-UK, V4, DOI 10.1038/srep06587
   Hu GX, 2013, PLOS ONE, V8, DOI [10.1371/journal.pone.0049976, 10.1371/journal.pone.0060700]
   Huang J, 2019, J HUM NUTR DIET, V32, P591, DOI 10.1111/jhn.12648
   Jäger R, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-11
   Jalali M, 2020, COMPLEMENT THER MED, V48, DOI 10.1016/j.ctim.2019.102283
   Jarhahzadeh M, 2021, DIABETOL METAB SYNDR, V13, DOI 10.1186/s13098-021-00731-7
   Jazayeri-Tehrani SA, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2017-016914
   Jurenka JS, 2009, ALTERN MED REV, V14, P141
   Kalmar B, 2009, ADV DRUG DELIVER REV, V61, P310, DOI 10.1016/j.addr.2009.02.003
   Karou SD, 2011, PHARM BIOL, V49, P1286, DOI 10.3109/13880209.2011.621959
   Karuppagounder V, 2017, NUTRITION, V34, P47, DOI 10.1016/j.nut.2016.09.005
   Kaur Ginpreet, 2012, ISRN Pharmacol, V2012, P957283, DOI 10.5402/2012/957283
   Kelany ME, 2017, CAN J PHYSIOL PHARM, V95, P140, DOI 10.1139/cjpp-2016-0152
   Kelardeh BM, 2020, J BODYW MOV THER, V24, P154, DOI 10.1016/j.jbmt.2020.02.021
   Khoomrung S, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00474
   Kobori M, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-27105-w
   Kunnumakkara AB, 2017, BRIT J PHARMACOL, V174, P1325, DOI 10.1111/bph.13621
   Lai M, 2014, NUTR DIABETES, V4, DOI 10.1038/nutd.2014.30
   Lee ES, 2020, METABOLISM, V103, DOI 10.1016/j.metabol.2019.154015
   Lee YK, 2009, J AGR FOOD CHEM, V57, P305, DOI 10.1021/jf802737z
   Lent-Schochet D, 2019, WORLD J DIABETES, V10, P23, DOI 10.4239/wjd.v10.i1.23
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Li W, 2017, MOL MED REP, V16, P4710, DOI 10.3892/mmr.2017.7205
   Liu Y, 2015, HUM EXP TOXICOL, V34, P620, DOI 10.1177/0960327114551396
   López-Jaramillo P, 2014, HORM MOL BIOL CLIN I, V18, P37, DOI 10.1515/hmbci-2013-0053
   Lopresti AL, 2018, ADV NUTR, V9, P41, DOI 10.1093/advances/nmx011
   Lu CW, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020548
   Luber Raphael P, 2019, Case Reports Hepatol, V2019, P6741213, DOI 10.1155/2019/6741213
   Mach CM, 2010, ANTICANCER RES, V30, P811
   Mahjoub S, 2012, CASP J INTERN MED, V3, P386
   Manikandan P, 2018, CURR DRUG TARGETS, V19, P38, DOI 10.2174/1389450118666170125144557
   Yubero-Serrano EM, 2013, EXP MOL MED, V45, DOI 10.1038/emm.2013.53
   Medicines Agency E, 2018, EUR UN HERB MON CURC
   Mirhafez SR, 2021, ADV EXP MED BIOL, V1328, P11, DOI 10.1007/978-3-030-73234-9_2
   Mirhafez SR, 2021, ADV EXP MED BIOL, V1308, P25, DOI 10.1007/978-3-030-64872-5_3
   Mirhafez SR, 2021, INT J VITAM NUTR RES, V91, P278, DOI 10.1024/0300-9831/a000629
   Mirhafez SR, 2019, J GASTROINTEST LIVER, V28, P183, DOI 10.15403/jgld-179
   Mohammadi A, 2017, PHYTOTHER RES, V31, P657, DOI 10.1002/ptr.5779
   Mohammadi F, 2019, J DIET SUPPL, V16, P592, DOI 10.1080/19390211.2018.1472710
   Mohammadi S, 2017, CELL J, V19, P425, DOI 10.22074/cellj.2017.4415
   Monnerie S, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-019-56909-7
   Montgomery MK, 2015, ENDOCR CONNECT, V4, DOI 10.1530/EC-14-0092
   Mousavi SM, 2020, CRIT REV FOOD SCI, V60, P171, DOI 10.1080/10408398.2018.1517724
   Neavin D, 2016, METABOLOMICS, V12, DOI 10.1007/s11306-016-1066-x
   Nicholson JK, 2008, NATURE, V455, P1054, DOI 10.1038/4551054a
   Olechnowicz J, 2018, J PHYSIOL SCI, V68, P19, DOI 10.1007/s12576-017-0571-7
   Osali A, 2020, DIABETOL METAB SYNDR, V12, DOI 10.1186/s13098-020-00532-4
   Pan MH, 1999, DRUG METAB DISPOS, V27, P486
   Pan SY, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/627375
   Panahi Y, 2019, J CELL BIOCHEM, V120, P15989, DOI 10.1002/jcb.28877
   Panahi Y, 2017, DRUG RES, V67, P244, DOI 10.1055/s-0043-100019
   Panahi Y, 2016, J CARDIOVASC PHARM, V68, P223, DOI 10.1097/FJC.0000000000000406
   Panahi Y, 2014, COMPLEMENT THER MED, V22, P851, DOI 10.1016/j.ctim.2014.07.006
   Pandey A, 2020, HELIYON, V6, DOI 10.1016/j.heliyon.2020.e05469
   Paolino D, 2016, FRONT PHARMACOL, V7, DOI 10.3389/fphar.2016.00485
   Patti AM, 2018, ARCH MED SCI, V14, P422, DOI 10.5114/aoms.2017.68717
   Peterson CT, 2018, J EVID-BASED INTEGR, V23, DOI 10.1177/2515690X18790725
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Polson AG, 2012, BRIT J PHARMACOL, V166, P1600, DOI 10.1111/j.1476-5381.2012.01916.x
   Prasad S, 2014, CANCER RES TREAT, V46, P2, DOI 10.4143/crt.2014.46.1.2
   Pujos-Guillot E, 2017, J PROTEOME RES, V16, P2262, DOI 10.1021/acs.jproteome.7b00116
   Qin S, 2018, NUTR RES, V60, P1, DOI 10.1016/j.nutres.2018.08.003
   Qin S, 2017, NUTR J, V16, DOI 10.1186/s12937-017-0293-y
   Rahmani S, 2016, PHYTOTHER RES, V30, P1540, DOI 10.1002/ptr.5659
   Ramzan F, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22095047
   Redekop WK, 2013, VALUE HEALTH, V16, pS4, DOI 10.1016/j.jval.2013.06.005
   Riddle MC, 2013, DIABETES CARE, V36, P2497, DOI 10.2337/dc12-2462
   Rinaldi L, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10020270
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Rosengren R., 2017, INT MED REV, V3, DOI [10.18103/imr.v3i11.631, DOI 10.18103/IMR.V3I11.631, 10.18103/IMR.V3I11.631]
   Round JL, 2009, NAT REV IMMUNOL, V9, P313, DOI 10.1038/nri2515
   Rózanski G, 2021, NUTRIENTS, V13, DOI 10.3390/nu13082654
   Saadati S, 2019, BMC GASTROENTEROL, V19, DOI 10.1186/s12876-019-1055-4
   Saadati S, 2019, EUR J CLIN NUTR, V73, P441, DOI 10.1038/s41430-018-0382-9
   Saberi-Karimian M, 2021, AVICENNA J PHYTOMEDI, V11, P190, DOI 10.22038/ajp.2020.16354
   Saberi-Karimian M, 2020, COMPLEMENT THER MED, V49, DOI 10.1016/j.ctim.2020.102322
   Sadeghi A, 2018, INFLAMMOPHARMACOLOGY, V26, P1265, DOI 10.1007/s10787-018-0466-0
   Safarian H., 2018, EFFECT CURCUMIN SERU, V16, P625, DOI [10.1080/19390211.2018.1472711, DOI 10.1080/19390211.2018.1472711]
   Sahebkar A, 2014, CLIN NUTR, V33, P406, DOI 10.1016/j.clnu.2013.09.012
   Salahshooh M. M., 2017, Comparative Clinical Pathology, V26, P17, DOI 10.1007/s00580-016-2339-5
   Schiborr C, 2014, MOL NUTR FOOD RES, V58, P516, DOI 10.1002/mnfr.201300724
   Scholze J, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-529
   Selmanovic Senada, 2017, Acta Inform Med, V25, P169, DOI 10.5455/aim.2017.25.169-174
   Shakour N, 2021, ADV EXP MED BIOL, V1308, P91, DOI 10.1007/978-3-030-64872-5_7
   Shamsi S, 2017, DRUG METAB DISPOS, V45, P49, DOI 10.1124/dmd.116.073213
   Sharifi-Rad J, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.01021
   Sherafat-Kazemzadeh R, 2013, INT J OBESITY, V37, P1, DOI 10.1038/ijo.2012.144
   Shim K, 2019, J DIABETES COMPLICAT, V33, P212, DOI 10.1016/j.jdiacomp.2018.12.002
   Siavash M, 2017, J RES PHARM PRACT, V6, P73, DOI 10.4103/jrpp.JRPP_17_2
   Silberberg M, 2006, EUR J NUTR, V45, P88, DOI 10.1007/s00394-005-0568-5
   Simental-Mendía LE, 2019, CRIT REV FOOD SCI, V59, P1178, DOI 10.1080/10408398.2017.1396201
   Singh L, 2021, MOLECULES, V26, DOI 10.3390/molecules26134036
   Sohal A, 2021, INT MED CASE REP J, V14, P849, DOI 10.2147/IMCRJ.S333342
   Soleimani V, 2018, PHYTOTHER RES, V32, P985, DOI 10.1002/ptr.6054
   Stati G, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.780330
   Tabatabaei-Malazy O, 2015, J DIABETES METAB DIS, V14, DOI 10.1186/s40200-015-0184-8
   Tabrizi R, 2019, PHYTOTHER RES, V33, P253, DOI 10.1002/ptr.6226
   Tabrizi R, 2018, CURR PHARM DESIGN, V24, P3184, DOI 10.2174/1381612824666180828162053
   Taghipour YD, 2019, INT J NANOMED, V14, P5303, DOI 10.2147/IJN.S213831
   Valentine SP, 2006, LIFE SCI, V78, P2391, DOI 10.1016/j.lfs.2005.09.017
   Valikhani D, 2021, ACS CATAL, V11, P9418, DOI 10.1021/acscatal.1c02017
   de Melo ISV, 2018, PHARMACOL RES, V128, P137, DOI 10.1016/j.phrs.2017.09.010
   Vietri M, 2003, XENOBIOTICA, V33, P357, DOI 10.1080/0049825031000065197
   Vogenberg F Randy, 2010, P T, V35, P560
   Volak LP, 2008, DRUG METAB DISPOS, V36, P1594, DOI 10.1124/dmd.108.020552
   Volak LP, 2013, BRIT J CLIN PHARMACO, V75, P450, DOI 10.1111/j.1365-2125.2012.04364.x
   Wang JJ, 2018, BIOMED CHROMATOGR, V32, DOI 10.1002/bmc.4267
   Wang LL, 2016, J LIPID RES, V57, P1243, DOI 10.1194/jlr.M067397
   White CM, 2019, PHARMACOL RES, V146, DOI 10.1016/j.phrs.2019.104280
   Wink M., 2022, ANNU REV FOOD SCI T, V13, p6.1, DOI [10.1146/annurev-food-052720-100326, DOI 10.1146/ANNUREV-FOOD-052720-100326]
   Wink Michael, 2015, Medicines (Basel), V2, P251, DOI 10.3390/medicines2030251
   Wong SK, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0123-9
   Wu GD, 2011, SCIENCE, V334, P105, DOI 10.1126/science.1208344
   Wu LY, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102307
   Xu XY, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101553
   Yang MX, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.00158
   Ye M, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00148
   Yiannakopoulou EC, 2013, PHARMACOGENOMICS J, V13, P105, DOI 10.1038/tpj.2012.42
   Yoysungnoen B, 2016, BIOMED RES INT, V2016, DOI 10.1155/2016/1781208
   Yu QQ, 2018, BIOMED PHARMACOTHER, V103, P1327, DOI 10.1016/j.biopha.2018.04.143
   Yuan F, 2019, ADV NUTR, V10, P791, DOI 10.1093/advances/nmz021
   Yun JM, 2011, J NUTR BIOCHEM, V22, P450, DOI 10.1016/j.jnutbio.2010.03.014
   Zaccardi F, 2016, POSTGRAD MED J, V92, P63, DOI 10.1136/postgradmedj-2015-133281
   Zanger UM, 2013, PHARMACOL THERAPEUT, V138, P103, DOI 10.1016/j.pharmthera.2012.12.007
   Zhou HY, 2011, CURR DRUG TARGETS, V12, P332, DOI 10.2174/138945011794815356
NR 196
TC 17
Z9 17
U1 7
U2 23
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JUN 9
PY 2022
VL 9
AR 891339
DI 10.3389/fnut.2022.891339
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 2I5BL
UT WOS:000814993400001
PM 35757255
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tesauro, M
   Cardillo, C
AF Tesauro, M.
   Cardillo, C.
TI Obesity, blood vessels and metabolic syndrome
SO ACTA PHYSIOLOGICA
LA English
DT Review
DE Endothelium; insulin; metabolic syndrome; obesity; oxidative stress;
   vascular reactivity
ID ENDOTHELIUM-DEPENDENT VASODILATION; EPICARDIAL ADIPOSE-TISSUE; SYNTHASE
   MESSENGER-RNA; NITRIC-OXIDE SYNTHASE; INSULIN-RESISTANCE; MICROVASCULAR
   RECRUITMENT; PERIVASCULAR FAT; GLUCOSE-UPTAKE; VASCULAR-TONE; TNF-ALPHA
AB Obesity is rising worldwide at an alarming rate and so is the incidence of obesity-related disorders, such as the metabolic syndrome, type 2 diabetes and cardiovascular diseases. The obesity-dependent vascular damage appears to be derived from a variety of changes in the adipose tissue, leading to a chronic inflammatory state and dysregulation of adipocyte-derived factors. This, in turn, impairs vascular homeostasis by determining an unbalance between the protective effect of the nitric oxide pathway and the unfavourable action of the endothelin-1 system. In addition, hyperinsulinemia and insulin resistance contribute to vascular dysfunction because the opposing endothelium-dependent vasodilating and vasoconstrictor effects of insulin are shifted towards a predominant vasoconstriction in patients with obesity. Importantly, emerging evidence suggests that the vascular dysfunction of obesity is not only limited to the endothelium but also involves the other layers of the vessel wall. In particular, obesity-related changes in vascular smooth muscle seem to disrupt the physiological facilitatory action of insulin on the responsiveness to vasodilator stimuli, whereas the adventitia and the perivascular fat appear to be a source of proinflammatory and vasoactive factors that may contribute to endothelial and smooth muscle cell dysfunction and to the pathogenesis of vascular disease.
C1 [Cardillo, C.] Univ Cattolica Sacro Cuore, Ist Patol Speciale Med & Semeiot, Dept Internal Med, I-00168 Rome, Italy.
   [Tesauro, M.] Univ Roma Tor Vergata, Dept Internal Med, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   University of Rome Tor Vergata
RP Cardillo, C (corresponding author), Univ Cattolica Sacro Cuore, Ist Patol Speciale Med & Semeiot, Dept Internal Med, Largo Gemelli 8, I-00168 Rome, Italy.
EM carmine.cardillo@rm.unicatt.it
OI Cardillo, Carmine/0000-0001-5182-3005
FU Fondazione Roma; Universita Cattolica del Sacro Cuore
FX This work was supported by a grant from the Fondazione Roma to M.
   Tesauro and by Fondi d'Ateneo grants from the Universita Cattolica del
   Sacro Cuore to C. Cardillo.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   BARON AD, 1995, J CLIN INVEST, V96, P786, DOI 10.1172/JCI118124
   Baron AD, 1997, ANNU REV NUTR, V17, P487, DOI 10.1146/annurev.nutr.17.1.487
   BREDT DS, 1994, ANNU REV BIOCHEM, V63, P175, DOI 10.1146/annurev.bi.63.070194.001135
   Cardillo C, 2004, HYPERTENSION, V43, P36, DOI 10.1161/01.HYP.0000103868.45064.81
   Cardillo C, 1999, CIRCULATION, V100, P820, DOI 10.1161/01.CIR.100.8.820
   Cardillo C, 1998, HYPERTENSION, V32, P740, DOI 10.1161/01.HYP.32.4.740
   Clark MG, 2003, AM J PHYSIOL-ENDOC M, V284, pE241, DOI 10.1152/ajpendo.00408.2002
   Clark MG, 2008, AM J PHYSIOL-ENDOC M, V295, pE732, DOI 10.1152/ajpendo.90477.2008
   Clerk LH, 2006, DIABETES, V55, P1436, DOI 10.2337/db05-1373
   DAVDA RK, 1995, HYPERTENSION, V26, P764, DOI 10.1161/01.HYP.26.5.764
   de Jongh RT, 2004, DIABETES, V53, P2873, DOI 10.2337/diabetes.53.11.2873
   de Jongh RT, 2004, CIRCULATION, V109, P2529, DOI 10.1161/01.CIR.0000129772.26647.6F
   De Keulenaer GW, 1998, BIOCHEM J, V329, P653
   deHaan CHA, 1997, CARDIOVASC RES, V34, P192, DOI 10.1016/S0008-6363(97)00035-7
   Djaberi R, 2008, AM J CARDIOL, V102, P1602, DOI 10.1016/j.amjcard.2008.08.010
   Dresner A, 1999, J CLIN INVEST, V103, P253, DOI 10.1172/JCI5001
   Eringa EC, 2004, AM J PHYSIOL-HEART C, V287, pH2043, DOI 10.1152/ajpheart.00067.2004
   Galic S, 2010, MOL CELL ENDOCRINOL, V316, P129, DOI 10.1016/j.mce.2009.08.018
   Gao YJ, 2005, J THORAC CARDIOV SUR, V130, P1130, DOI 10.1016/j.jtcvs.2005.05.028
   Greenstein AS, 2009, CIRCULATION, V119, P1661, DOI 10.1161/CIRCULATIONAHA.108.821181
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Hosogai N, 2007, DIABETES, V56, P901, DOI 10.2337/db06-0911
   Hotamisligil GS, 1996, SCIENCE, V271, P665, DOI 10.1126/science.271.5249.665
   Huang PL, 2005, CIRC RES, V96, P1129, DOI 10.1161/01.RES.0000170705.56583.45
   Kahn BB, 2000, J CLIN INVEST, V106, P473, DOI 10.1172/JCI10842
   Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213
   LAAKSO M, 1990, J CLIN INVEST, V85, P1844, DOI 10.1172/JCI114644
   Lau DCW, 2005, AM J PHYSIOL-HEART C, V288, pH2031, DOI 10.1152/ajpheart.01058.2004
   Lee DE, 2009, AM J PHYSIOL-ENDOC M, V296, pE1210, DOI 10.1152/ajpendo.00015.2009
   LEVIN ER, 1995, NEW ENGL J MED, V333, P356, DOI 10.1056/NEJM199508103330607
   LIND L, 1993, AM HEART J, V125, P1494, DOI 10.1016/0002-8703(93)90446-G
   Lteif A, 2007, DIABETES, V56, P728, DOI 10.2337/db06-1406
   Lu G, 1998, HYPERTENSION, V32, P1003, DOI 10.1161/01.HYP.32.6.1003
   Mather KJ, 2004, DIABETES, V53, P2060, DOI 10.2337/diabetes.53.8.2060
   MOHAMED F, 1995, ARTERIOSCL THROM VAS, V15, P52, DOI 10.1161/01.ATV.15.1.52
   Perticone F, 2001, DIABETES, V50, P159, DOI 10.2337/diabetes.50.1.159
   Piatti P, 1996, DIABETES, V45, P316, DOI 10.2337/diabetes.45.3.316
   Rask-Madsen C, 2003, CIRCULATION, V108, P1815, DOI 10.1161/01.CIR.0000091406.72832.11
   Saltiel AR, 2001, NATURE, V414, P799, DOI 10.1038/414799a
   Schinzari F, 2010, AM J PHYSIOL-ENDOC M, V299, pE947, DOI 10.1152/ajpendo.00426.2010
   Shulman GI, 2000, J CLIN INVEST, V106, P171, DOI 10.1172/JCI10583
   Steinberg HO, 1997, J CLIN INVEST, V100, P1230, DOI 10.1172/JCI119636
   Steinberg HO, 1996, J CLIN INVEST, V97, P2601, DOI 10.1172/JCI118709
   Tack CJJ, 1996, HYPERTENSION, V28, P426, DOI 10.1161/01.HYP.28.3.426
   Tesauro M, 2005, CIRCULATION, V112, P2986, DOI 10.1161/CIRCULATIONAHA.105.553883
   Tesauro M, 2008, DIABETES CARE, V31, P1439, DOI 10.2337/dc08-0219
   Tesauro M, 2009, HYPERTENSION, V54, P995, DOI 10.1161/HYPERTENSIONAHA.109.137729
   Van Guilder GP, 2006, J CARDIOVASC PHARM, V47, P310, DOI 10.1097/01.fjc.0000205097.29946.d3
   Vicent D, 2003, J CLIN INVEST, V111, P1373, DOI 10.1172/JCI200315211
   Vincent MA, 2003, AM J PHYSIOL-ENDOC M, V285, pE123, DOI 10.1152/ajpendo.00021.2003
   Wang CP, 2009, CLIN ENDOCRINOL, V70, P876, DOI 10.1111/j.1365-2265.2008.03411.x
   Watanabe S, 2005, ARTERIOSCL THROM VAS, V25, P2376, DOI 10.1161/01.ATV.0000187465.55507.85
   Wellen KE, 2003, J CLIN INVEST, V112, P1785, DOI 10.1172/JCI20514
   Yach D, 2006, NAT MED, V12, P62, DOI 10.1038/nm0106-62
   Yki-Järvinen H, 1998, DIABETOLOGIA, V41, P369, DOI 10.1007/s001250050919
   YOSHIZUMI M, 1993, CIRC RES, V73, P205, DOI 10.1161/01.RES.73.1.205
   Yudkin JS, 2005, LANCET, V365, P1817, DOI 10.1016/S0140-6736(05)66585-3
   Zeng GY, 2000, CIRCULATION, V101, P1539, DOI 10.1161/01.CIR.101.13.1539
   Zhang L, 2004, DIABETES, V53, P447, DOI 10.2337/diabetes.53.2.447
   Zhang L, 2003, AM J PHYSIOL-ENDOC M, V285, pE654, DOI 10.1152/ajpendo.00119.2003
   Ziccardi P, 2002, CIRCULATION, V105, P804, DOI 10.1161/hc0702.104279
NR 62
TC 77
Z9 86
U1 1
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1748-1708
EI 1748-1716
J9 ACTA PHYSIOL
JI Acta Physiol.
PD SEP
PY 2011
VL 203
IS 1
SI SI
BP 279
EP 286
DI 10.1111/j.1748-1716.2011.02290.x
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 807TA
UT WOS:000293921400026
PM 21439028
DA 2025-06-11
ER

PT J
AU Valado, A
   Cunha, M
   Pereira, L
AF Valado, Ana
   Cunha, Margarida
   Pereira, Leonel
TI Biomarkers and Seaweed-Based Nutritional Interventions in Metabolic
   Syndrome: A Comprehensive Review
SO MARINE DRUGS
LA English
DT Review
DE metabolic syndrome; obesity; cardiovascular disease; biomarkers;
   therapy; marine algae
ID BLOOD-PRESSURE; OBESITY; ALGAE
AB Metabolic Syndrome (MetS) is a complex, multifactorial condition characterized by risk factors such as abdominal obesity, insulin resistance, dyslipidemia and hypertension, which significantly contribute to the development of cardiovascular disease (CVD), the leading cause of death worldwide. Early identification and effective monitoring of MetS is crucial for preventing serious cardiovascular complications. This article provides a comprehensive overview of various biomarkers associated with MetS, including lipid profile markers (triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio and apolipoprotein B/apolipoprotein A1 (ApoB/ApoA1) ratio), inflammatory markers (interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha), plasminogen activator inhibitor type 1 (PAI-1), C-reactive protein (CRP), leptin/adiponectin ratio, omentin and fetuin-A/adiponectin ratio), oxidative stress markers (lipid peroxides, protein and nucleic acid oxidation, gamma-glutamyl transferase (GGT), uric acid) and microRNAs (miRNAs) such as miR-15a-5p, miR5-17-5p and miR-24-3p. Additionally, this review highlights the importance of biomarkers in MetS and the need for advancements in their identification and use for improving prevention and treatment. Seaweed therapy is also discussed as a significant intervention for MetS due to its rich content of fiber, antioxidants, minerals and bioactive compounds, which help improve cardiovascular health, reduce inflammation, increase insulin sensitivity and promote weight loss, making it a promising nutritional strategy for managing metabolic and cardiovascular health.
C1 [Valado, Ana; Cunha, Margarida] Polytech Univ Coimbra, Coimbra Hlth Sch, Biomed Lab Sci, Rua 5 Outubro S Martinho Bispo,Apartado 7006, P-3045043 Coimbra, Portugal.
   [Valado, Ana] Polytech Univ Coimbra, Res Ctr Nat Resources Environm Soc CERNAS, P-3045601 Bencanta, Coimbra, Portugal.
   [Valado, Ana] Univ Coimbra, MARE Marine & Environm Sci Ctr, ARNET Aquat Res Network, P-3000456 Coimbra, Portugal.
   [Valado, Ana] Polytech Univ Coimbra, H&TRC Hlth & Technol Res Ctr, Coimbra Hlth Sch, Rua 5 Outubro, P-3045043 Coimbra, Portugal.
   [Pereira, Leonel] Univ Coimbra, Ctr Funct Ecol Sci People & Planet, Dept Life Sci, Marine Resources Conservat & Technol Marine Algae, P-3000456 Coimbra, Portugal.
C3 Universidade de Coimbra; Universidade de Coimbra
RP Valado, A (corresponding author), Polytech Univ Coimbra, Coimbra Hlth Sch, Biomed Lab Sci, Rua 5 Outubro S Martinho Bispo,Apartado 7006, P-3045043 Coimbra, Portugal.; Valado, A (corresponding author), Polytech Univ Coimbra, Res Ctr Nat Resources Environm Soc CERNAS, P-3045601 Bencanta, Coimbra, Portugal.; Valado, A (corresponding author), Univ Coimbra, MARE Marine & Environm Sci Ctr, ARNET Aquat Res Network, P-3000456 Coimbra, Portugal.; Valado, A (corresponding author), Polytech Univ Coimbra, H&TRC Hlth & Technol Res Ctr, Coimbra Hlth Sch, Rua 5 Outubro, P-3045043 Coimbra, Portugal.
EM valado@estesc.ipc.pt; margaridacunha2002@hotmail.com;
   leonel.pereira@uc.pt
RI Valado, Ana/ABG-5698-2020; Valado, Ana/ADI-6397-2022; Pereira,
   Leonel/M-3527-2013
OI Valado, Ana/0000-0002-0157-6648; Pereira, Leonel/0000-0002-6819-0619
FU Portuguese Foundation for Science and Technology (FCT)
   [UIDB/00681/2020]; FCT-Fundacao para a Ciencia e Tecnologia, I.P.
   [UIDB/04004/2020]
FX The author AV thanks the Portuguese Foundation for Science and
   Technology (FCT) for the financial support to the Research Centre for
   Natural Resources, Environment and Society-CERNAS (UIDB/00681/2020;
   doi:10.54499/UIDP/00681/2020). This work was also supported by
   FCT-Fundacao para a Ciencia e Tecnologia, I.P., in the framework of the
   Project UIDB/04004/2020 and DOI identifier 10.54499/UIDB/04004/2020
   (doi:10.54499/UIDB/04004/2020 accessed on 30 July 2024).
CR Abbasian F, 2023, HELIYON, V9, DOI 10.1016/j.heliyon.2023.e19399
   Alkhulaifi F, 2022, NUTRIENTS, V14, DOI 10.3390/nu14091719
   Aoe S, 2021, MAR DRUGS, V19, DOI 10.3390/md19070352
   Askin L, 2020, CURR CARDIOL REV, V16, P198, DOI 10.2174/1573403X16666200511085304
   Ba HJ, 2019, CLIN MED INSIGHTS-PE, V13, DOI 10.1177/1179556519853780
   Batiha GES, 2022, DIABETOL METAB SYNDR, V14, DOI 10.1186/s13098-022-00900-2
   Bilska K, 2023, NUTRIENTS, V15, DOI 10.3390/nu15214532
   Brandao BB, 2022, J PHYSIOL-LONDON, V600, P1155, DOI 10.1113/JP280910
   Butnariu LI, 2023, DIAGNOSTICS, V13, DOI 10.3390/diagnostics13142348
   Cherry P, 2019, MAR DRUGS, V17, DOI 10.3390/md17060327
   Cherry P, 2019, NUTR REV, V77, P307, DOI 10.1093/nutrit/nuy066
   Cho Y, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph192215003
   Cotas J, 2020, MAR DRUGS, V18, DOI 10.3390/md18080384
   Cura-Esquivel I, 2023, PLOS ONE, V18, DOI 10.1371/journal.pone.0281381
   De Martin S, 2018, NAT PROD COMMUN, V13, P1691
   Deiuliis JA, 2016, INT J OBESITY, V40, P88, DOI 10.1038/ijo.2015.170
   du Preez R, 2021, NUTRIENTS, V13, DOI 10.3390/nu13061754
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Frak W, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10081938
   Frazier-wood A.C., 2016, METABOLIC SYNDROME, P447, DOI [10.1007/978-3-319-11251-0, DOI 10.1007/978-3-319-11251-0]
   Gabbia D, 2020, MOLECULES, V25, DOI 10.3390/molecules25184182
   Puscaselu RG, 2020, POLYMERS-BASEL, V12, DOI 10.3390/polym12102417
   Gherghina ME, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23063188
   Gómez-Guzmán M, 2018, MAR DRUGS, V16, DOI 10.3390/md16080250
   Grander C, 2016, VISC MED, V32, P329, DOI 10.1159/000448940
   Guerrero-Wyss M, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms241310779
   Gunathilaka TL, 2020, J DIABETES RES, V2020, DOI 10.1155/2020/1230218
   Hata Y, 2001, J CLIN BIOCHEM NUTR, V30, P43
   Heyn GS, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.563816
   Hitoe S, 2017, FUNCT FOODS HEALTH D, V7, P246
   Holdt SL, 2011, J APPL PHYCOL, V23, P543, DOI 10.1007/s10811-010-9632-5
   Hurtado-Roca Y, 2017, DIABETES, V66, P474, DOI 10.2337/db16-0933
   Hutny M, 2022, PEDIATR OBES, V17, DOI 10.1111/ijpo.12880
   Ismail MM, 2020, MOLECULES, V25, DOI 10.3390/molecules25194411
   Jeong H, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2019-029861
   Jeong J, 2019, J KOREAN MED SCI, V34, DOI 10.3346/jkms.2019.34.e307
   Karkeni E, 2018, EPIGENETICS-US, V13, P156, DOI 10.1080/15592294.2016.1276681
   Keleszade E, 2021, MOLECULES, V26, DOI 10.3390/molecules26030714
   Kim CO, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071513
   Kim JE, 2022, MOLECULES, V27, DOI 10.3390/molecules27020334
   Kimura Y, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222212394
   Kir S, 2019, ACTA ENDOCRINOL-BUCH, V15, P430, DOI 10.4183/aeb.2019.430
   Kojta I, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051305
   Landrier JF, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8080859
   Lee KW, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17093287
   Levine JA, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-020-79948-x
   Li YX, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.687586
   Liu J, 2021, NUTRIENTS, V13, DOI 10.3390/nu13082887
   Mahdavi-Roshan M, 2022, INT J ENDOCRINOL MET, V20, DOI 10.5812/ijem-127445
   Makiel K, 2023, J CLIN MED, V12, DOI 10.3390/jcm12082822
   Masenga SK, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24097898
   Mashhadi NS, 2018, ASIA PAC J CLIN NUTR, V27, P341, DOI 10.6133/apjcn.052017.11
   Mednova IA, 2020, METABOLITES, V10, DOI 10.3390/metabo10100410
   Monserrat-Mesquida M, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9030236
   Murakami S, 2023, FOOD SCI NUTR, V11, P599, DOI 10.1002/fsn3.3100
   Murakami S, 2022, NUTR METAB, V19, DOI 10.1186/s12986-021-00633-5
   Murakami S, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020551
   Nawaz Shaik Sarfaraz, 2022, Cytokine X, V4, P100064, DOI 10.1016/j.cytox.2022.100064
   Nicolucci Antonio, 2021, J Diabetes Res, V2021, P3389316, DOI 10.1155/2021/3389316
   Nie GQ, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2020-041519
   nih, Metabolic Syndrome-Diagnosis
   Iwani AKNZ, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.852290
   Obradovic M, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.585887
   Ogurtsova K, 2017, DIABETES RES CLIN PR, V128, P40, DOI 10.1016/j.diabres.2017.03.024
   Ormazabal V, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0762-4
   Pan XF, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0229776
   Pelczynska M, 2021, BIOMOLECULES, V11, DOI 10.3390/biom11121863
   Pereira L, 2024, NUTRIENTS, V16, DOI 10.3390/nu16081123
   Pereira L, 2023, LIFE-BASEL, V13, DOI 10.3390/life13091831
   Rafaqat Saira, 2021, J Atr Fibrillation, V14, P20200495, DOI 10.4022/jafib.20200495
   Ragino YI, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10030374
   Ramzan F, 2020, ACTA DIABETOL, V57, P203, DOI 10.1007/s00592-019-01406-6
   Rana S, 2022, J DIABETES METAB DIS, V21, P1095, DOI 10.1007/s40200-022-01009-z
   Regufe Virginia M G, 2020, Porto Biomed J, V5, pe101, DOI 10.1097/j.pbj.0000000000000101
   Rezapour M, 2018, ARCH IRAN MED, V21, P572
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Rus M, 2023, MEDICINA-LITHUANIA, V59, DOI 10.3390/medicina59101711
   Russo S, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.746151
   Ryu B, 2021, MAR DRUGS, V19, DOI 10.3390/md19090507
   Saeedi P, 2019, DIABETES RES CLIN PR, V157, DOI 10.1016/j.diabres.2019.107843
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sangaleti CT, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.613979
   Shannon E, 2021, MAR DRUGS, V19, DOI 10.3390/md19070358
   Shi J, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00703
   Soppert J, 2020, ADV DRUG DELIVER REV, V159, P4, DOI 10.1016/j.addr.2020.07.019
   Sun XS, 2022, DIABET METAB SYND OB, V15, P3913, DOI 10.2147/DMSO.S388620
   Tavares JO, 2023, MAR DRUGS, V21, DOI 10.3390/md21110578
   Thomas MS, 2022, NUTRIENTS, V14, DOI 10.3390/nu14122548
   Tylutka A, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-022-27269-6
   Uchinaka A, 2017, PHARMACOL RES PERSPE, V5, DOI 10.1002/prp2.331
   Ulloque-Badaracco JR, 2023, LIPIDS HEALTH DIS, V22, DOI 10.1186/s12944-023-01860-w
   Valado A., 2022, Nutraceuticals, V2, P441, DOI 10.3390/nutraceuticals2040032
   Valado A, 2020, MAR DRUGS, V18, DOI 10.3390/md18010019
   Pacheco LV, 2020, MAR DRUGS, V18, DOI 10.3390/md18070353
   Vodouhè M, 2022, MAR DRUGS, V20, DOI 10.3390/md20030174
   Vona R, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8267234
   Vonhögen IGC, 2020, NON-CODING RNA RES, V5, P144, DOI 10.1016/j.ncrna.2020.08.001
   Wei ZK, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23031706
   Wells ML, 2017, J APPL PHYCOL, V29, P949, DOI 10.1007/s10811-016-0974-5
   Zahedi AS, 2023, HELIYON, V9, DOI 10.1016/j.heliyon.2023.e19911
   Zang LQ, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1173225
   Zarghamravanbakhsh Paria, 2021, Metabol Open, V12, P100149, DOI 10.1016/j.metop.2021.100149
   Zhang BJ, 2021, OBESITY FACTS, V14, P456, DOI 10.1159/000515720
   Zhou ZW, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-01251-5
NR 104
TC 1
Z9 1
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-3397
J9 MAR DRUGS
JI Mar. Drugs
PD DEC
PY 2024
VL 22
IS 12
AR 550
DI 10.3390/md22120550
PG 28
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA Q4Y6D
UT WOS:001384757300001
PM 39728125
OA gold
DA 2025-06-11
ER

PT J
AU Alshehri, FF
AF Alshehri, Faez Falah
TI Understanding the prevalence, progression, and management of metabolic
   syndrome in Saudi Arabia
SO SAUDI MEDICAL JOURNAL
LA English
DT Review
DE metabolic syndrome (MetS); hypertension; insulin resistance; diabetes;
   obesity; phytochemicals
ID PHOENIX-DACTYLIFERA L.; C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA;
   HEART-RATE-VARIABILITY; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   DIETARY FIBER; EICOSAPENTAENOIC ACID; MYOCARDIAL-INFARCTION;
   PHENOLIC-COMPOUNDS
AB Metabolic syndrome (MetS) is characterized by the coexistence of several disorders comprising hypertension, abdominal obesity, insulin sensitivity, and dyslipidemia. In recent times, MetS has gained increased attention due to the global prevalence of obesity. Adipose tissue plays a crucial role in this syndrome by releasing various molecules significantly affecting lipid/insulin regulation, oxidative stress, and cardiovascular function. Tumor necrosis factor-alpha (p-alpha), an inflammatory cytokine, and adiponectin, an adipose tissue-specific protein, are considered vital adipokines that play a significant role in the pathogenesis of MetS. The impact of dietary ingredients on MetS management has been extensively studied over the past few decades. These plant-derived natural chemicals have demonstrated beneficial impacts on obesity, diabetes, and cardiovascular disease (CVD) due to their diverse properties. Saudi Arabia has a high prevalence of overweight and diabetes, but there has been limited research on the incidence of MetS in the country. As a result, in this review, we evaluated the prevalence of MetS in Saudi Arabia and its associated risk factors, as well as explored the mechanisms of progression of MetS and the role of natural phytochemicals in the prevention of MetS.
C1 [Alshehri, Faez Falah] Shaqra Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Shaqra, Saudi Arabia.
C3 Shaqra University
RP Alshehri, FF (corresponding author), Shaqra Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Shaqra, Saudi Arabia.
EM falshehri@su.edu.sa
RI ALSHEHRI, FAEZ/GZG-4968-2022
OI Alshehri, Faez/0000-0001-7991-0987
FU Deanship of Scientific Research at Shaqra University
FX Acknowledgment. The author would like to thank the Deanship of
   Scientific Research at Shaqra University for supporting this work. The
   author would also like to acknowledge ContentCincepts (
   www.contentconcepts.com ) for the English language editing.
CR Aggarwal BB, 2010, ANNU REV NUTR, V30, P173, DOI 10.1146/annurev.nutr.012809.104755
   Ahmed J., 2014, Dates: postharvest science, processing technology and health benefits, P261
   Ahmed S, 2017, PAK J PHARM SCI, V30, P1797
   Akbar D., 2002, Diabetes Int, V12, P47
   Al-Alawi RA, 2017, FRONT PLANT SCI, V8, DOI 10.3389/fpls.2017.00845
   Al-Daghri NM, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012159
   Al-Nozha MM, 2005, SAUDI MED J, V26, P1918
   Al-Nozha MM, 2004, SAUDI MED J, V25, P1165
   Al-Qurashi MM, 2009, SAUDI MED J, V30, P926
   Al-Rubeaan K, 2018, BMC ENDOCR DISORD, V18, DOI 10.1186/s12902-018-0244-4
   Al-Rubeaan K, 2014, ANN SAUDI MED, V34, P465, DOI 10.5144/0256-4947.2014.465
   Al-Rubean K, 2017, ANN SAUDI MED, V37, P21, DOI 10.5144/0256-4947.2017.21
   Al-Waili NS, 2004, J MED FOOD, V7, P100, DOI 10.1089/109662004322984789
   Al-Yahya M, 2016, PHYTOMEDICINE, V23, P1240, DOI 10.1016/j.phymed.2015.10.019
   Alansare A, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15071508
   Alassiri M, 2020, EXPLORE-NY, V16, P264, DOI 10.1016/j.explore.2020.02.006
   Albert MA, 2006, CIRCULATION, V114, P2619, DOI 10.1161/CIRCULATIONAHA.106.660043
   Alberti K George M M, 2006, Curr Diab Rep, V6, P259, DOI 10.1007/s11892-006-0057-0
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Ali RB, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-39
   Aljefree N, 2015, Adv. Public Health, V2015
   Alkahtani S, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17082719
   Alsunni A, 2015, ANN SAUDI MED, V35, P282, DOI 10.5144/0256-4947.2015.282
   Alvarez-Pérez J, 2016, J AM COLL NUTR, V35, P568, DOI 10.1080/07315724.2015.1102102
   Alzaabi A, 2019, ENDOCRIN DIAB METAB, V2, DOI 10.1002/edm2.81
   Alzahrani A.M., 2012, The British Journal of Diabetes & Vascular Disease, V12, P78, DOI [10.1177/1474651412441953, DOI 10.1177/1474651412441953]
   Aman P., 2006, Scandinavian Journal of Food & Nutrition, V50, P173, DOI 10.1080/17482970601057990
   Anderson JW, 2000, AM J CLIN NUTR, V71, P1433
   Arbex PM, 2018, J FUNCT FOODS, V42, P346, DOI 10.1016/j.jff.2018.01.010
   Barrimah IE, 2009, INT J HEALTH SCI-IJH, V3, P133
   Bennet AM, 2002, EUR J ENDOCRINOL, V147, P641, DOI 10.1530/eje.0.1470641
   Berlin I, 2012, TOB INDUC DIS, V10, DOI 10.1186/1617-9625-10-9
   Borena W, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0089368
   Bose M, 2008, J NUTR, V138, P1677, DOI 10.1093/jn/138.9.1677
   Brennan CS, 2005, MOL NUTR FOOD RES, V49, P560, DOI 10.1002/mnfr.200500025
   Brown L, 1999, AM J CLIN NUTR, V69, P30
   CAMPBELL IL, 1987, MOL CELL ENDOCRINOL, V52, P161, DOI 10.1016/0303-7207(87)90109-2
   Cao HP, 2010, PHYTOMEDICINE, V17, P1027, DOI 10.1016/j.phymed.2010.03.023
   Cardoso LD, 2015, J CEREAL SCI, V65, P220, DOI 10.1016/j.jcs.2015.06.015
   Chaari A, 2020, INT J BIOL MACROMOL, V164, P1794, DOI 10.1016/j.ijbiomac.2020.08.080
   Chiva-Blanch G, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061696
   Choudhary Prema Ram, 2018, Journal of Dietary Supplements, V15, P499, DOI 10.1080/19390211.2017.1358233
   Daubresse J C, 2000, Rev Med Brux, V21, P473
   El Abed H, 2017, BIOMED PHARMACOTHER, V88, P835, DOI 10.1016/j.biopha.2017.01.129
   Elemam AE, 2020, BIOMED RES INT, V2020, DOI 10.1155/2020/7382164
   Esmaillzadeh A, 2005, EUR J CLIN NUTR, V59, P353, DOI 10.1038/sj.ejcn.1602080
   Esposito K, 2002, J ENDOCRINOL INVEST, V25, P646, DOI 10.1007/BF03345092
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   Ge YC, 2018, MINI-REV MED CHEM, V18, P1590, DOI 10.2174/1389557518666180423151426
   Ghavipour M, 2015, CLIN NUTR, V34, P805, DOI 10.1016/j.clnu.2014.10.012
   Ghnimi S., 2017, NFS Journal, V6, P1, DOI [10.1016/j.nfs.2016.12.001, DOI 10.1016/J.NFS.2016.12.001]
   Gillies PJ, 2012, J LIPID RES, V53, P1679, DOI 10.1194/jlr.M022657
   Gillingham LG, 2011, LIPIDS, V46, P209, DOI 10.1007/s11745-010-3524-y
   Gómez-Arbeláez D, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/285795
   Greenberg AS, 2002, EUR J CLIN INVEST, V32, P24, DOI 10.1046/j.1365-2362.32.s3.4.x
   Grimble RF, 2002, CURR OPIN CLIN NUTR, V5, P551, DOI 10.1097/00075197-200209000-00015
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Guerendiain M, 2017, CLIN NUTR, V36, P209, DOI 10.1016/j.clnu.2015.11.001
   Guo W, 2005, LIPIDS, V40, P815, DOI 10.1007/s11745-005-1443-8
   Han GM, 2017, EUR J INTEGR MED, V13, P34, DOI 10.1016/j.eujim.2017.07.002
   Han GM, 2016, NUTR RES, V36, P402, DOI 10.1016/j.nutres.2016.01.003
   Hasan M, 2016, J CLIN DIAGN RES, V10, pFF6, DOI 10.7860/JCDR/2016/16879.7419
   HOTAMISLIGIL GS, 1994, P NATL ACAD SCI USA, V91, P4854, DOI 10.1073/pnas.91.11.4854
   Hussein K, 2013, J HOSP INFECT, V83, P307, DOI 10.1016/j.jhin.2012.10.012
   Jang H, 2020, CLIN NUTR, V39, P765, DOI 10.1016/j.clnu.2019.03.032
   Jensen MK, 2004, AM J CLIN NUTR, V80, P1492, DOI 10.1093/ajcn/80.6.1492
   Joseph SV, 2016, CRIT REV FOOD SCI, V56, P419, DOI 10.1080/10408398.2013.767221
   KAPLAN NM, 1989, ARCH INTERN MED, V149, P1514, DOI 10.1001/archinte.149.7.1514
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Katsuki A, 1998, J CLIN ENDOCR METAB, V83, P859, DOI 10.1210/jc.83.3.859
   Kavazarakis E, 2002, PEDIATR RES, V52, P454, DOI [10.1203/00006450-200209000-00025, 10.1203/01.PDR.0000025349.12010.24]
   Khan MA, 2016, ANN SAUDI MED, V36, P23, DOI 10.5144/0256-4947.2016.23
   Latif R, 2020, EXPLORE-NY, V16, P372, DOI 10.1016/j.explore.2019.12.009
   Lee YS, 2006, DIABETES, V55, P2256, DOI 10.2337/db06-0006
   Lin CJ, 2006, LIFE SCI, V79, P144, DOI 10.1016/j.lfs.2005.12.031
   Lindsay RS, 2002, LANCET, V360, P57, DOI 10.1016/S0140-6736(02)09335-2
   Linseisen J, 2009, EUR J CLIN NUTR, V63, pS61, DOI 10.1038/ejcn.2009.75
   Lionetti L, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0092753
   Liu R, 2020, J NUTR BIOCHEM, V79, DOI 10.1016/j.jnutbio.2019.108330
   Liu SM, 2003, AM J CLIN NUTR, V77, P594, DOI 10.1093/ajcn/77.3.594
   Lyon CJ, 2003, ENDOCRINOLOGY, V144, P2195, DOI 10.1210/en.2003-0285
   McKeown NM, 2004, DIABETES CARE, V27, P538, DOI 10.2337/diacare.27.2.538
   Mehta PK, 2007, AM J PHYSIOL-CELL PH, V292, pC82, DOI 10.1152/ajpcell.00287.2006
   Mohamud WNW, 2011, DIABETES RES CLIN PR, V91, P239, DOI 10.1016/j.diabres.2010.11.025
   Mohieldein AH, 2015, DIABETES METAB SYND, V9, P287, DOI 10.1016/j.dsx.2014.04.017
   Mooradian AD, 2009, NAT CLIN PRACT ENDOC, V5, P150, DOI 10.1038/ncpendmet1066
   Nemoseck TM, 2011, NUTR RES, V31, P55, DOI 10.1016/j.nutres.2010.11.002
   O'Mahoney LL, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0740-x
   Okon E, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21041330
   Önning G, 1999, ANN NUTR METAB, V43, P301, DOI 10.1159/000012798
   Osei-Yeboah J, 2017, Int J Chronic Dis, V2017
   Ouchi N, 2000, CIRCULATION, V102, P1296, DOI 10.1161/01.CIR.102.11.1296
   Padiya R, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-53
   Palaniappan L, 2004, DIABETES CARE, V27, P788, DOI 10.2337/diacare.27.3.788
   Pasceri V, 2000, CIRCULATION, V102, P2165
   Pérez-Rubio KG, 2013, METAB SYNDR RELAT D, V11, P366, DOI 10.1089/met.2012.0183
   Pinto J, 2011, BRIT J NUTR, V105, P1607, DOI 10.1017/S000711451000526X
   Pischon T, 2004, JAMA-J AM MED ASSOC, V291, P1730, DOI 10.1001/jama.291.14.1730
   Prabhakaran D, 2004, VASC MED, V9, P55, DOI 10.1191/1358863x04vm515ra
   Pradhan AD, 2002, CIRCULATION, V106, P820, DOI 10.1161/01.CIR.0000025636.03561.EE
   Qi L, 2006, DIABETES CARE, V29, P207, DOI 10.2337/diacare.29.02.06.dc05-1903
   Ranneh Y, 2019, NUTR METAB, V16, DOI 10.1186/s12986-019-0341-z
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Reinhart KM, 2009, NUTR RES REV, V22, P39, DOI 10.1017/S0954422409350003
   Riad K, 2018, FRONT NUTR, V5, DOI 10.3389/fnut.2018.00122
   Romero-Silva S, 2011, LETT DRUG DES DISCOV, V8, P69, DOI 10.2174/157018011793663912
   Ruan XZ, 2009, J DIABETES, V1, P236, DOI 10.1111/j.1753-0407.2009.00042.x
   Rubio-Ruiz ME, 2013, CURR MED CHEM, V20, P2626, DOI 10.2174/0929867311320210002
   Sae-Tan S, 2011, PHARMACOL RES, V64, P146, DOI 10.1016/j.phrs.2010.12.013
   Saeed AA, 2019, Open J Endocr Metab Dis, V9, P49
   Saghizadeh M, 1996, J CLIN INVEST, V97, P1111, DOI 10.1172/JCI118504
   Sahyoun NR, 2006, AM J CLIN NUTR, V83, P124
   Saibandith B, 2017, MOLECULES, V22, DOI 10.3390/molecules22071082
   Saini RK, 2017, 3 BIOTECH, V7, DOI 10.1007/s13205-017-0666-0
   Shehzad A, 2012, FUTURE ONCOL, V8, P179, DOI [10.2217/FON.11.145, 10.2217/fon.11.145]
   Slavin JL, 2005, NUTRITION, V21, P411, DOI 10.1016/j.nut.2004.08.018
   Son BK, 2008, ANN NUTR METAB, V52, P181, DOI 10.1159/000138121
   Lopes RDSO, 2018, FOOD RES INT, V107, P629, DOI 10.1016/j.foodres.2018.03.004
   Tamakoshi K, 2003, INT J OBESITY, V27, P443, DOI 10.1038/sj.ijo.0802260
   Thielecke F, 2009, PHYTOCHEMISTRY, V70, P11, DOI 10.1016/j.phytochem.2008.11.011
   Thomas G, 2011, CLIN J AM SOC NEPHRO, V6, P2364, DOI 10.2215/CJN.02180311
   Tooke JE, 1998, DIABETES CARE, V21, P2047, DOI 10.2337/diacare.21.12.2047
   Tripoli E, 2005, NUTR RES REV, V18, P98, DOI 10.1079/NRR200495
   Tsigos C, 1999, METABOLISM, V48, P1332, DOI 10.1016/S0026-0495(99)90277-9
   Vanecková I, 2014, J ENDOCRINOL, V223, pR63, DOI 10.1530/JOE-14-0368
   Viguiliouk E, 2018, NUTR DIABETES, V8, DOI 10.1038/s41387-018-0066-5
   Villegas R, 2003, DIABETES CARE, V26, P3198, DOI 10.2337/diacare.26.11.3198-a
   Wainstein J, 2012, J MED FOOD, V15, P605, DOI 10.1089/jmf.2011.0243
   Wallace AM, 2001, CIRCULATION, V104, P3052, DOI 10.1161/hc5001.101061
   Wang CC, 2006, AM J CLIN NUTR, V84, P5, DOI 10.1093/ajcn/84.1.5
   Weickert MO, 2008, J NUTR, V138, P439, DOI 10.1093/jn/138.3.439
   Xu JY, 2003, AM J PHYSIOL-GASTR L, V285, pG20, DOI 10.1152/ajpgi.00474.2002
   Yaghoobi N, 2008, THESCIENTIFICWORLDJO, V8, P463, DOI 10.1100/tsw.2008.64
   Yang J, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/363845
   Zeb I, 2018, CORONARY ARTERY DIS, V29, P325, DOI 10.1097/MCA.0000000000000587
   Zeng ZH, 2017, EXP CLIN ENDOCR DIAB, V125, P610, DOI 10.1055/s-0043-101919
   Zidani S, 2017, J NUTR BIOCHEM, V40, P164, DOI 10.1016/j.jnutbio.2016.11.001
   Ziegenfuss TN, 2006, J INT SOC SPORT NUTR, V3, DOI 10.1186/1550-2783-3-2-45
   Zimmet P, 2005, REV ESP CARDIOL, V58, P1371, DOI 10.1016/S1885-5857(06)60742-1
   Zwaka TP, 2001, CIRCULATION, V103, P1194
NR 140
TC 4
Z9 4
U1 0
U2 3
PU SAUDI MED J
PI RIYADH
PA ARMED FORCES HOSPITAL, PO BOX 7897,, RIYADH 11159, SAUDI ARABIA
SN 0379-5284
EI 1658-3175
J9 SAUDI MED J
JI Saudi Med. J.
PD OCT 1
PY 2023
VL 44
IS 10
BP 973
EP 986
DI 10.15537/smj.2023.44.10.20230450
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA X3UV1
UT WOS:001097747200003
PM 37777274
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Dehelean, L
   Romosan, AM
   Manea, MM
   Papava, I
   Andor, M
   Romosan, RS
AF Dehelean, L.
   Romosan, A. M.
   Manea, M. M.
   Papava, I
   Andor, M.
   Romosan, R. S.
TI THE METABOLIC SYNDROME IN OUTPATIENTS WITH PSYCHOSIS: A COMPARATIVE
   STUDY BETWEEN LONG ACTING INJECTABLE OLANZAPINE AND RISPERIDONE
SO ACTA ENDOCRINOLOGICA-BUCHAREST
LA English
DT Article
DE metabolic syndrome; long acting injectable; olanzapine; risperidone
ID INDUCED WEIGHT-GAIN; ATYPICAL ANTIPSYCHOTICS; DIABETES-MELLITUS;
   SCHIZOPHRENIA; PREVALENCE; SMOKING; PEOPLE; RISK
AB Context. Literature shows that patients taking antipsychotic medication risk developing metabolic complications.
   Objective. The study aims to compare the presence of the metabolic syndrome (MS) and its components in outpatients treated with long acting injectable (LAI) olanzapine and risperidone.
   Design. A double-center study was performed on outpatients with psychosis, which were divided into two samples: one treated with olanzapine and another with risperidone.
   Subjects and Methods. The following data were analyzed: age, gender, severity of psychiatric symptoms, blood pressure, waist circumference, fasting blood glucose, lipid profile, tobacco use, medication, and time intervals related to psychosis duration (pre-LAI and LAI treatment).
   Results. The study included 77 patients with schizophrenia and schizoaffective disorder. MS was present in 45 (58.4%) patients. Subjects with MS and abdominal obesity had higher durations of psychosis and of LAI treatment. Patients with hypertension had a higher pre-LAI treatment interval. Risperidone was associated with higher rates of hypertension and higher values of abdominal circumference than olanzapine.
   Conclusions. The presence of MS is related to the duration of the psychosis and the time spent on LAI treatment with no differences between olanzapine and risperidone. Hypertension may be a consequence of age, disorder induced stress, or of treatment with risperidone.
C1 [Dehelean, L.; Romosan, A. M.; Papava, I; Romosan, R. S.] Victor Babes Univ Med & Pharm, Dept Neurosci, Timisoara, Romania.
   [Andor, M.] Victor Babes Univ Med & Pharm, Med Semiol 2, Timisoara, Romania.
   [Manea, M. M.] Cty Clin Emergency Hosp, Dept Psychiat, Cluj Napoca, Romania.
   [Manea, M. M.] Iuliu Hatieganu Univ Med & Pharm, Fac Med, Dept Med Educ, Cluj Napoca, Romania.
C3 Victor Babes University of Medicine & Pharmacy, Timisoara; Victor Babes
   University of Medicine & Pharmacy, Timisoara; Iuliu Hatieganu University
   of Medicine & Pharmacy
RP Romosan, AM (corresponding author), Victor Babes Univ Med & Pharm, 2 Eftimie Murgu Sq, Timisoara 300041, Romania.
EM ana.romosan@gmail.com
RI Romosan, Radu-Stefan/B-3402-2016; Romosan, Ana/LWH-7382-2024; Andor,
   Minodora/KEH-5890-2024; Papava, Ion/ADB-0622-2022; Dehelean,
   Liana/P-2768-2016
OI ROMOSAN, RADU-STEFAN/0000-0001-6823-5277
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Allison DB, 2001, J CLIN PSYCHIAT, V62, P22
   Amer Diabet Assoc, 2004, DIABETES CARE, V27, P596, DOI 10.2337/diacare.27.2.596
   Bridler R, 2003, SWISS MED WKLY, V133, P63
   Bushe C, 2004, BRIT J PSYCHIAT, V184, pS67, DOI 10.1192/bjp.184.47.s67
   Carrillo JA, 2003, J CLIN PSYCHOPHARM, V23, P119, DOI 10.1097/00004714-200304000-00003
   Davidson S, 2001, AUST NZ J PSYCHIAT, V35, P196, DOI 10.1046/j.1440-1614.2001.00877.x
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Gex-Fabry M, 2003, THER DRUG MONIT, V25, P46, DOI 10.1097/00007691-200302000-00007
   Gilmer TP, 2004, AM J PSYCHIAT, V161, P692, DOI 10.1176/appi.ajp.161.4.692
   Hanley AJG, 2005, CIRCULATION, V112, P3713, DOI 10.1161/CIRCULATIONAHA.105.559633
   Kane JM, 2003, AM J PSYCHIAT, V160, P1125, DOI 10.1176/appi.ajp.160.6.1125
   Kim SF, 2007, P NATL ACAD SCI USA, V104, P3456, DOI 10.1073/pnas.0611417104
   Kohen D, 2004, BRIT J PSYCHIAT, V184, pS64, DOI 10.1192/bjp.184.47.s64
   Kroeze WK, 2003, NEUROPSYCHOPHARMACOL, V28, P519, DOI 10.1038/sj.npp.1300027
   Ladea M, 2013, ACTA ENDOCRINOL-BUCH, V9, P647, DOI 10.4183/aeb.2013.647
   Lencz T, 2010, PHARMACOGENET GENOM, V20, P569, DOI 10.1097/FPC.0b013e32833ca24b
   Leucht S, 2005, BRIT J PSYCHIAT, V187, P366, DOI 10.1192/bjp.187.4.366
   Lindenmayer JP, 2010, NEUROPSYCH DIS TREAT, V6, P261
   LUKOFF D, 1986, SCHIZOPHRENIA BULL, V12, P578, DOI 10.1093/schbul/12.4.578
   Matei VP, 2016, ACTA ENDOCRINOL-BUCH, V12, P177, DOI 10.4183/aeb.2016.177
   MEGENS AAHP, 1994, PSYCHOPHARMACOLOGY, V114, P9, DOI 10.1007/BF02245439
   Meyer JM, 2002, J CLIN PSYCHIAT, V63, P425, DOI 10.4088/JCP.v63n0509
   Meyer JM, 2008, SCHIZOPHR RES, V101, P273, DOI 10.1016/j.schres.2007.12.487
   Mihalache L, 2012, ACTA ENDOCRINOL-BUCH, V8, P595, DOI 10.4183/aeb.2012.595
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Newcomer JW, 2005, CNS DRUGS, V19, P1
   OVERALL JE, 1962, PSYCHOL REP, V10, P799
   Remington G, 2006, AM J PSYCHIAT, V163, P1132, DOI 10.1176/appi.ajp.163.7.1132
   Reynolds Gavin P, 2006, J Psychopharmacol, V20, P15, DOI 10.1177/1359786806066040
   Robinson DS, 2006, PRIM PSYCH, V13, P26
   Saddichha S, 2008, SCHIZOPHR RES, V101, P266, DOI 10.1016/j.schres.2008.01.004
   Simon V, 2009, J CLIN PSYCHIAT, V70, P1041, DOI 10.4088/JCP.08r04392
   Stahl SM, 2000, ESSENTIAL PSYCHOPHAR, P433
   Velligan D, 2005, PSYCHIAT RES, V135, P217, DOI 10.1016/j.psychres.2005.05.001
   Zipursky RB, 2005, BRIT J PSYCHIAT, V187, P537, DOI 10.1192/bjp.187.6.537
NR 36
TC 4
Z9 4
U1 0
U2 4
PU EDITURA ACAD ROMANE
PI BUCURESTI
PA CALEA 13 SEPTEMBRIE NR 13, SECTOR 5, BUCURESTI 050711, ROMANIA
SN 1841-0987
EI 1843-066X
J9 ACTA ENDOCRINOL-BUCH
JI Acta Endocrinol.
PD JUL-SEP
PY 2019
VL 15
IS 3
BP 342
EP 348
DI 10.4183/aeb.2019.342
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA KQ4FP
UT WOS:000516880800010
PM 32010353
OA Green Published
DA 2025-06-11
ER

PT J
AU Hickman, IJ
   Hannigan, AK
   Johnston, HE
   Elvin-Walsh, L
   Mayr, HL
   Staudacher, HM
   Barnett, A
   Stoney, R
   Salisbury, C
   Jarrett, M
   Reeves, MM
   Coombes, JS
   Campbell, KL
   Keating, SE
   Macdonald, GA
AF Hickman, Ingrid J.
   Hannigan, Amy K.
   Johnston, Heidi E.
   Elvin-Walsh, Louise
   Mayr, Hannah L.
   Staudacher, Heidi M.
   Barnett, Amandine
   Stoney, Rachel
   Salisbury, Chloe
   Jarrett, Maree
   Reeves, Marina M.
   Coombes, Jeff S.
   Campbell, Katrina L.
   Keating, Shelley E.
   Macdonald, Graeme A.
TI Telehealth-delivered, Cardioprotective Diet and Exercise Program for
   Liver Transplant Recipients: A Randomized Feasibility Study
SO TRANSPLANTATION DIRECT
LA English
DT Article
ID QUALITY-OF-LIFE; ACHIEVE HIGH ADHERENCE; LOW-FAT DIETS; MEDITERRANEAN
   DIET; CARDIOVASCULAR RISK; INTERVENTION; ADULTS; DISEASE; HEART;
   AUSTRALIANS
AB Background.
   Rapid excess weight gain and metabolic complications contribute to poor outcomes following liver transplant care. Providing specialist lifestyle intervention with equitable access is a challenge for posttransplant service delivery.
   Methods.
   This study investigated the feasibility of a 12-wk telehealth delivered lifestyle intervention for liver transplant recipients (randomized controlled trial with a delayed intervention control group). The intervention included 14 group sessions facilitated by nutrition and exercise specialists via video streaming telehealth and participants used their own devices. Feasibility was assessed across session attendance, the adequacy, acceptability, and confidence with the telehealth technology and adherence to diet (Mediterranean Diet Adherence Score). Secondary pooled analysis of effectiveness was determined from changes in quality of life and metabolic syndrome severity score.
   Results.
   Of the 35 participants randomized, dropout was 22.8% (n = 8) and overall session attendance rate was 60%. Confidence with and adequacy of home technology was rated high in 96% and 91% of sessions, respectively. Participants randomized to the intervention significantly improved Mediterranean Diet Adherence Score (2-point increase [95% confidence interval, 1.5-3.4] versus control 0 point change [95% confidence interval, -1.4 to 1.2]; P = 0.004). Intervention (within group) analysis found the intervention significantly decreased the metabolic syndrome severity score (-0.4 [95% confidence interval, -0.6 to -0.1] P = 0.01), and improved mental health-related quality of life (2.5 [95% confidence interval, 0.4-4.6] P = 0.03).
   Conclusions.
   A cardioprotective lifestyle intervention delivered via telehealth is feasible for liver transplant recipients and may improve access to specialist care to support metabolic health and wellness after transplant.
C1 [Hickman, Ingrid J.; Hannigan, Amy K.; Johnston, Heidi E.; Elvin-Walsh, Louise; Mayr, Hannah L.; Staudacher, Heidi M.; Barnett, Amandine; Stoney, Rachel; Campbell, Katrina L.] Princess Alexandra Hosp, Dept Nutr & Dietet, Brisbane, Qld, Australia.
   [Hickman, Ingrid J.] Univ Queensland, Mater Res Inst, Brisbane, Qld, Australia.
   [Hickman, Ingrid J.; Mayr, Hannah L.; Campbell, Katrina L.; Macdonald, Graeme A.] Univ Queensland, Fac Med, Brisbane, Qld, Australia.
   [Mayr, Hannah L.; Barnett, Amandine] Bond Univ, Fac Hlth Sci & Med, Nutr & Dietet Res Grp, Gold Coast, Qld, Australia.
   [Salisbury, Chloe; Coombes, Jeff S.; Keating, Shelley E.] Univ Queensland, Sch Human Movement & Nutr Sci, Brisbane, Qld, Australia.
   [Jarrett, Maree; Macdonald, Graeme A.] Princess Alexandra Hosp, Queensland Liver Transplant Serv, Brisbane, Qld, Australia.
   [Campbell, Katrina L.] Griffith Univ, Menzies Hlth Inst, Ctr Appl Hlth Econ, Brisbane, Qld, Australia.
   [Macdonald, Graeme A.] Princess Alexandra Hosp, Dept Gastroenterol & Hepatol, Brisbane, Qld, Australia.
C3 Princess Alexandra Hospital; University of Queensland; Mater Research;
   University of Queensland; Bond University; University of Queensland;
   Princess Alexandra Hospital; Griffith University; Menzies Health
   Institute Queensland; Princess Alexandra Hospital
RP Hickman, IJ (corresponding author), Princess Alexandra Hosp, Dept Nutr & Dietet, Ipswich Rd, Woolloongabba, Qld 4102, Australia.
EM i.hickman@uq.edu.au
RI Reeves, Marina/B-3813-2009; Staudacher, Heidi/AAC-8193-2022; Campbell,
   Katrina/A-2290-2013; Keating, Shelley/P-2520-2015; Staudacher, Heidi
   M/D-2700-2017; Macdonald, Graeme A/K-4167-2013; Hickman, Ingrid
   J/P-8364-2016
OI Keating, Shelley/0000-0001-5357-2721; Barnett,
   Amandine/0000-0003-1509-1729; Staudacher, Heidi M/0000-0001-6704-2131;
   Macdonald, Graeme A/0000-0003-0929-110X; Salisbury,
   Chloe/0000-0001-8974-9736; Hickman, Ingrid J/0000-0003-3205-9165; Mayr,
   Hannah L/0000-0001-7356-653X
FU Princess Alexandra Hospital Research Support Scheme, Princess Alexandra
   Hospital Research Foundation; Allied Health Professionals Office of
   Queensland
FX Project funding was received from the Princess Alexandra Hospital
   Research Support Scheme, Princess Alexandra Hospital Research
   Foundation, and the Allied Health Professionals Office of Queensland.
CR Martínez-González MA, 2017, NUTRIENTS, V9, DOI 10.3390/nu9111226
   Martínez-González MA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043134
   [Anonymous], 2001, INT STANDARDS ANTHRO
   Australia and New Zealand Liver and Intestinal Transplant Registry, 2020, ANZLITR 30 ANN REP 2
   Babio N, 2014, CAN MED ASSOC J, V186, pE649, DOI 10.1503/cmaj.140764
   Barnett A, 2021, J TELEMED TELECARE, V27, P590, DOI 10.1177/1357633X19900459
   Bendall CL, 2018, CRIT REV FOOD SCI, V58, P3070, DOI 10.1080/10408398.2017.1351917
   Beyer N, 1999, LIVER TRANSPLANT SUR, V5, P301, DOI 10.1002/lt.500050406
   Brown WJ, 2012, Report prepared for the Australian government department of, Health
   Burra P, 2016, J HEPATOL, V64, P433, DOI 10.1016/j.jhep.2015.10.006
   Chatterton ML, 2018, BMC PUBLIC HEALTH, V18, DOI 10.1186/s12889-018-5504-8
   Coombes J., 2014, ESSA's student manual for health, exercise and sport assessment
   Davis C, 2017, NUTRIENTS, V9, DOI 10.3390/nu9060534
   De Bona M, 2000, J HEPATOL, V33, P609, DOI 10.1034/j.1600-0641.2000.033004609.x
   Di Noia J, 2019, CONT CLIN TRIAL COMM, V16, DOI 10.1016/j.conctc.2019.100438
   Dinu M, 2018, EUR J CLIN NUTR, V72, P30, DOI 10.1038/ejcn.2017.58
   Echeverría G, 2019, EUR J CLIN NUTR, V72, P38, DOI 10.1038/s41430-018-0307-7
   Entwistle TR, 2018, NUTR J, V17, DOI 10.1186/s12937-018-0337-y
   Entwistle VA, 2018, HEALTH CARE ANAL, V26, P48, DOI 10.1007/s10728-016-0335-1
   Esposito K, 2011, METAB SYNDR RELAT D, V9, P1, DOI 10.1089/met.2010.0031
   Estruch R, 2006, ANN INTERN MED, V145, P1, DOI 10.7326/0003-4819-145-1-200607040-00004
   Flodgren G, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002098.pub2
   Haigh L, 2019, CLIN GASTROENTEROL H, V17, P1364, DOI 10.1016/j.cgh.2018.10.044
   Hickman IJ, 2019, NUTR DIET, V76, P399, DOI 10.1111/1747-0080.12548
   Huys N, 2020, BMC PUBLIC HEALTH, V20, DOI 10.1186/s12889-020-09336-7
   Hwang R, 2017, J PHYSIOTHER, V63, P101, DOI 10.1016/j.jphys.2017.02.017
   Jacobs DR, 2018, METABOLISM, V85, P361, DOI 10.1016/j.metabol.2018.05.001
   Jayasinghe UW, 2013, HEALTH QUAL LIFE OUT, V11, DOI 10.1186/1477-7525-11-102
   Keating SE, 2020, ARCH REHAB RES CLIN, V2, DOI 10.1016/j.arrct.2020.100066
   Knight A, 2016, AGEING RES REV, V25, P85, DOI 10.1016/j.arr.2015.10.005
   Krasnoff JB, 2006, AM J TRANSPLANT, V6, P1896, DOI 10.1111/j.1600-6143.2006.01391.x
   Leimig R, 2008, PROG TRANSPLANT, V18, P97, DOI 10.7182/prtr.18.2.n14x9420p2711620
   Lemyze Malcolm, 2010, Presse Med, V39, pe174, DOI 10.1016/j.lpm.2009.09.027
   Liu-Seifert H, 2010, PATIENT PREFER ADHER, V4, P11
   Mayr HL, 2019, NUTRITION, V61, P21, DOI 10.1016/j.nut.2018.10.027
   Mccoy SM, 2017, HEPATOBIL SURG NUTR, V6, P317, DOI 10.21037/hbsn.2017.01.12
   Moya-Nájera D, 2017, LIVER TRANSPLANT, V23, P1273, DOI 10.1002/lt.24827
   Murray EM, 2014, NUTR DIET, V71, P86, DOI 10.1111/1747-0080.12079
   Papadaki A, 2018, NUTRIENTS, V10, DOI 10.3390/nu10020138
   Patel SS, 2020, DIGEST DIS SCI, V65, P639, DOI 10.1007/s10620-019-05800-6
   Properzi C, 2018, HEPATOLOGY, V68, P1741, DOI 10.1002/hep.30076
   Radd-Vagenas S, 2018, NUTRIENTS, V10, DOI 10.3390/nu10121913
   Ratcliffe J, 2002, LIVER TRANSPLANT, V8, P263, DOI 10.1053/jlts.2002.31345
   Rollo ME, 2018, NUTR DIET, V75, P35, DOI 10.1111/1747-0080.12335
   Segal L, 2020, NUTR NEUROSCI, V23, P770, DOI 10.1080/1028415X.2018.1556896
   Serper M, 2020, TRANSPL INT, V33, P632, DOI 10.1111/tri.13570
   Thodis A, 2018, NUTR DIET, V75, P44, DOI 10.1111/1747-0080.12360
   Thompson PD, 2013, CURR SPORT MED REP, V12, P215, DOI 10.1249/JSR.0b013e31829a68cf
   Totti V, 2019, TRANSPL P, V51, P2952, DOI 10.1016/j.transproceed.2019.03.087
   Totti V, 2019, TRANSPL P, V51, P2902, DOI 10.1016/j.transproceed.2019.02.074
   Viglione Clare, 2019, BMC Obes, V6, P4, DOI 10.1186/s40608-018-0226-0
   Wallen MP, 2019, LIVER TRANSPLANT, V25, P1576, DOI 10.1002/lt.25616
   Ware JE, 1996, MED CARE, V34, P220, DOI 10.1097/00005650-199603000-00003
   Webster P, 2020, LANCET, V395, P1180, DOI 10.1016/S0140-6736(20)30818-7
   Whelan ME, 2016, TRANSL BEHAV MED, V6, P386, DOI 10.1007/s13142-015-0337-9
   Wiley JF, 2016, PREV MED, V88, P189, DOI 10.1016/j.ypmed.2016.04.006
   Williams FR, 2019, LIVER TRANSPLANT, V25, P995, DOI 10.1002/lt.25442
NR 57
TC 28
Z9 30
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2373-8731
J9 TRANSPLANT DIRECT
JI Transplant. Direct.
PD MAR
PY 2021
VL 7
IS 3
AR e667
DI 10.1097/TXD.0000000000001118
PG 10
WC Transplantation
WE Emerging Sources Citation Index (ESCI)
SC Transplantation
GA RM3VL
UT WOS:000639591800004
PM 33564717
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Krawczuk-Rybak, M
   Panasiuk, A
   Czygier, M
   Muszynska-Roslan, K
   Wysocka, J
   Szmitkowski, M
AF Krawczuk-Rybak, Maryna
   Panasiuk, Anna
   Czygier, Malgorzata
   Muszynska-Roslan, Katarzyna
   Wysocka, Jolanta
   Szmitkowski, Maciej
TI Total antioxidant status (TAS) in childhood cancer survivors
SO FOLIA HISTOCHEMICA ET CYTOBIOLOGICA
LA English
DT Article
DE cancer survivors; children; antioxidants; metabolic syndrome
ID ACUTE LYMPHOBLASTIC-LEUKEMIA; OXIDATIVE STRESS; CHILDREN; OBESITY;
   CHEMOTHERAPY; IMPACT; DAMAGE
AB Total antioxidant status (TAS), and the influence of treatment and correlation between TAS and parameters involved in metabolic syndrome (MS) in pediatric cancer survivors were evaluated. One hundred children and adolescents were studied. Twenty-five survivors received radiotherapy, 12 were obese or overweight. Additionally, we analyzed TAS in eight children with acute lymphoblastic leukemia (ALL) at diagnosis and during treatment after remission induction. The control group consisted of 22 healthy children. Serum concentrations of TAS, glucose, cholesterol, HDL-cholesterol, triglycerides, fibrinogen and insulin were measured. In cancer survivors, independently of diagnosis and kind of treatment (radiotherapy anthracyclines administration), the mean serum TAS did not differ significantly from the control group. No correlations were observed with age at the time of diagnosis or interval after the end of treatment. TAS values did not correlate with traits of the metabolic syndrome. In a group of eight patients with ALL at diagnosis and after induction of remission, TAS values were lower than in the control and cancer survivor groups. Antioxidant status was not found to be deteriorated in children after anticancer treatment, irrespective of diagnosis or kind of treatment, which might indicate sufficient antioxidant prevention. However, the possibility of the development of MS and cardiovascular disease in adulthood indicates the need for future studies. (Folia Histochemica et Cytobiologica 2012, Vol. 50, No. 3, 468-472)
C1 [Krawczuk-Rybak, Maryna; Panasiuk, Anna; Muszynska-Roslan, Katarzyna] Med Univ Bialystok, Dept Pediat Oncol & Hematol, PL-15274 Bialystok, Poland.
   [Czygier, Malgorzata; Szmitkowski, Maciej] Med Univ Bialystok, Dept Biochem Diagnost, PL-15274 Bialystok, Poland.
   [Wysocka, Jolanta] Med Univ Bialystok, Dept Pediat Lab Diagnost, PL-15274 Bialystok, Poland.
C3 Medical University of Bialystok; Medical University of Bialystok;
   Medical University of Bialystok
RP Krawczuk-Rybak, M (corresponding author), Med Univ Bialystok, Dept Pediat Oncol & Hematol, Waszyngtona Str 17, PL-15274 Bialystok, Poland.
EM rybak@umwb.edu.pl
RI Muszyńska-Rosłan, Katarzyna/U-7749-2018; Krawczuk-Rybak,
   Maryna/T-6734-2018
OI Krawczuk-Rybak, Maryna/0000-0003-0899-5930
CR Al-Tonbary Y, 2011, HEMATOLOGY, V16, P14, DOI 10.1179/102453311X12902908411553
   Battisti V, 2008, CLIN BIOCHEM, V41, P511, DOI 10.1016/j.clinbiochem.2008.01.027
   Bhatia S, 2009, CANCER J, V15, P174, DOI 10.1097/PPO.0b013e3181a58f46
   Block KI, 2008, INT J CANCER, V123, P1227, DOI 10.1002/ijc.23754
   Caron JE, 2009, PEDIATR BLOOD CANCER, V53, P551, DOI 10.1002/pbc.22128
   Chow EJ, 2007, CANCER-AM CANCER SOC, V110, P2313, DOI 10.1002/cncr.23050
   Dimitrijevic-Sreckovic V, 2007, CLIN CHEM LAB MED, V45, P1140, DOI 10.1515/CCLM.2007.259
   Fryer C, 2011, PEDIAT BLOOD CANC, V10, P1
   Giannini C, 2009, EUR J ENDOCRINOL, V161, P73, DOI 10.1530/EJE-09-0042
   Hoffman KE, 2008, PEDIATR BLOOD CANCER, V50, P341, DOI 10.1002/pbc.21363
   Karamouzis I, 2011, HORM METAB RES, V43, P607, DOI 10.1055/s-0031-1284355
   Kasapowic J, 2010, CLIN BIOCHEM, V43, P16
   Kennedy DD, 2005, PEDIATR BLOOD CANCER, V44, P378, DOI 10.1002/pbc.20307
   Klaunig JE, 2010, TOXICOL PATHOL, V38, P96, DOI 10.1177/0192623309356453
   Mazor D, 2008, PEDIATR BLOOD CANCER, V51, P613, DOI 10.1002/pbc.21665
   Molnár D, 2004, INT J OBESITY, V28, P1197, DOI 10.1038/sj.ijo.0802719
   Ondrejovicova I, 2010, Prague Med Rep, V111, P300
   Pietilä S, 2009, PEDIATR BLOOD CANCER, V52, P853, DOI 10.1002/pbc.21936
   Sakhi AK, 2010, NUTR CANCER, V62, P322, DOI 10.1080/01635580903441188
   Shankar SM, 2008, PEDIATRICS, V121, pE387, DOI 10.1542/peds.2007-0575
   Simunek T, 2009, PHARMACOL REP, V61, P154
   Siviero-Miachon AA, 2008, VASC HEALTH RISK MAN, V4, P825
   Stenzel SL, 2010, J PEDIAT HEMATOL ONC, V32, P113, DOI 10.1097/MPH.0b013e3181c9af84
   Trachtenberg BH, 2011, PEDIATR CARDIOL, V32, P342, DOI 10.1007/s00246-010-9878-3
   van Waas M, 2010, ANN ONCOL, V21, P1121, DOI 10.1093/annonc/mdp414
   Yarnold J, 2010, RADIOTHER ONCOL, V97, P149, DOI 10.1016/j.radonc.2010.09.002
   Yeon JY, 2011, NUTRITION, V27, P912, DOI 10.1016/j.nut.2010.10.012
   Zhao W, 2007, BRIT J RADIOL, V80, pS23, DOI 10.1259/bjr/18237646
NR 28
TC 5
Z9 5
U1 0
U2 5
PU VIA MEDICA
PI GDANSK
PA UL SWIETOKRZYSKA 73, 80-180 GDANSK, POLAND
SN 0239-8508
EI 1897-5631
J9 FOLIA HISTOCHEM CYTO
JI Folia Histochem. Cytobiol.
PY 2012
VL 50
IS 3
BP 468
EP 472
DI 10.5603/FHC.2012.0065
PG 5
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 049QU
UT WOS:000311999300022
PM 23042281
OA gold
DA 2025-06-11
ER

PT J
AU Giral, P
   Jacob, N
   Dourmap, C
   Hansel, B
   Carrie, A
   Bruckert, E
   Girerd, X
   Chapman, MJ
AF Giral, Philippe
   Jacob, Nelly
   Dourmap, Caroline
   Hansel, Boris
   Carrie, Alain
   Bruckert, Eric
   Girerd, Xavier
   Chapman, M. John
TI Elevated gamma-glutamyltransferase activity and perturbed thiol profile
   are associated with features of metabolic syndrome
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE metabolic syndrome; gamma-glutamyltransferase; glutathione; cysteine;
   oxidation
ID LOW-DENSITY-LIPOPROTEIN; CARDIOVASCULAR-DISEASE MORTALITY; HUMAN
   ATHEROSCLEROTIC PLAQUES; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   RISK-FACTOR; HYPERLIPIDEMIC PATIENTS; MYOCARDIAL-INFARCTION;
   VASCULAR-DISEASE; AUSTRIAN ADULTS
AB Background-Prospective cohort studies have revealed that plasma gamma-glutamyltransferase (GGT) activity exhibits a positive association with coronary artery disease. GGT which is equally elevated in metabolic syndrome (MS), is the major regulator of circulating concentrations of thiol compounds derived from glutathione (GSH) cleavage, ie, cysteine and cysteinyl glycine. We compared the circulating thiol profile in a cohort of patients displaying atherogenic dyslipidemia with and without MS.
   Methods and Results-This cross-sectional study involved 1131 dyslipidemic patients in primary prevention of whom 26% presented with MS. GGT activity and plasma cysteinyl-glycine and cysteine concentrations were higher in MS patients; by contrast, levels of GSH were significantly lower (P < 10 to 4 for all comparisons versus patients without MS). We compared patient groups on the basis of the number of MS criteria which were concomitantly present. A progressive decrease in glutathione levels in contrast to a progressive increase in both cysteinyl-glycine and cysteine levels, and GGT activity, was observed as a function of the number of MS components in the overall population (P for trend < 10(-6)).
   Conclusion-Dyslipidemic patients exhibiting MS are characterized by elevated GGT activity which is associated with perturbed metabolism of thiol compounds.
C1 [Giral, Philippe; Dourmap, Caroline; Hansel, Boris; Bruckert, Eric; Girerd, Xavier] Univ Paris 06, Grp Hop Pitie Salpetriere, Unites Prevent Cardiovasc, Serv Endocrinol Metab,AP HP, F-75651 Paris, France.
   [Jacob, Nelly] Univ Paris 06, Grp Hop Pitie Salpetriere, Biochim Lab, AP HP, F-75651 Paris, France.
   [Giral, Philippe; Hansel, Boris; Carrie, Alain; Bruckert, Eric; Girerd, Xavier; Chapman, M. John] Univ Paris 06, INSERM, UMRS 551, Dyslipoproteinemia & Atherosclerosis Res Unit, F-75651 Paris, France.
   [Carrie, Alain] Univ Paris 06, Serv Biochim Med, AP HP, Grp Hop Pitie Salpetriere, F-75651 Paris, France.
C3 Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Pitie-Salpetriere - APHP; Sorbonne Universite; Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere
   - APHP; Sorbonne Universite; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP);
   Hopital Universitaire Pitie-Salpetriere - APHP; Sorbonne Universite
RP Giral, P (corresponding author), Univ Paris 06, Grp Hop Pitie Salpetriere, Unites Prevent Cardiovasc, Serv Endocrinol Metab,AP HP, 47-83 Blvd Hop, F-75651 Paris, France.
EM philippe.giral@psl.aphp.fr
RI chapman, john/Y-2742-2019
OI Carrie, Alain/0000-0003-4726-1171
CR Altman DG, 1990, PRACTICAL STAT MED R
   André P, 2006, DIABETOLOGIA, V49, P2599, DOI 10.1007/s00125-006-0418-x
   Ashfaq S, 2006, J AM COLL CARDIOL, V47, P1005, DOI 10.1016/j.jacc.2005.09.063
   Berliner JA, 2005, NEW ENGL J MED, V353, P9, DOI 10.1056/NEJMp058118
   Bruckert E, 2002, METABOLISM, V51, P1071, DOI 10.1053/meta.2002.34046
   Drozdz R, 1998, FREE RADICAL BIO MED, V25, P786, DOI 10.1016/S0891-5849(98)00127-0
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   El-Khairy L, 2001, CIRCULATION, V103, P2544
   Esposito K, 2006, J ENDOCRINOL INVEST, V29, P791, DOI 10.1007/BF03347372
   Ferroni Patrizia, 2004, Curr Atheroscler Rep, V6, P424, DOI 10.1007/s11883-004-0082-x
   Ginsberg HN, 2006, OBESITY, V14, p41S, DOI 10.1038/oby.2006.281
   Giral P, 2006, CIRCULATION, V113, pE299, DOI 10.1161/CIRCULATIONAHA.105.594176
   Giral P, 2001, ATHEROSCLEROSIS, V154, P421, DOI 10.1016/S0021-9150(00)00474-3
   Go YM, 2005, CIRCULATION, V111, P2973, DOI 10.1161/CIRCULATIONAHA.104.515155
   Griendling KK, 2003, CIRCULATION, V108, P1912, DOI 10.1161/01.CIR.0000093660.86242.BB
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hanley AJG, 2004, DIABETES, V53, P2623, DOI 10.2337/diabetes.53.10.2623
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Harrison D, 2003, AM J CARDIOL, V91, p7A
   HEINECKE JW, 1993, J LIPID RES, V34, P2051
   Heistad DD, 2006, ARTERIOSCL THROM VAS, V26, P689, DOI 10.1161/01.ATV.0000203525.62147.28
   Holvoet P, 2004, DIABETES, V53, P1068, DOI 10.2337/diabetes.53.4.1068
   Hu G, 2004, ARCH INTERN MED, V164, P1066, DOI 10.1001/archinte.164.10.1066
   Jacob N, 1999, ATHEROSCLEROSIS, V146, P53, DOI 10.1016/S0021-9150(99)00128-8
   Jeppesen J, 2006, ATHEROSCLEROSIS, V189, P369, DOI 10.1016/j.atherosclerosis.2005.12.010
   Jones DP, 2004, FASEB J, V18, P1246, DOI 10.1096/fj.03-0971fje
   Kathiresan S, 2006, CIRCULATION, V113, P20, DOI 10.1161/CIRCULATIONAHA.105.567107
   KLAUKE R, 1993, EUR J CLIN CHEM CLIN, V31, P901
   Lapenna D, 1998, CIRCULATION, V97, P1930, DOI 10.1161/01.CIR.97.19.1930
   Lee DS, 2007, ARTERIOSCL THROM VAS, V27, P127, DOI 10.1161/01.ATV.0000251993.20372.40
   Lim JS, 2004, FREE RADICAL BIO MED, V37, P1018, DOI 10.1016/j.freeradbiomed.2004.06.032
   Lonardo A, 2006, J HEPATOL, V44, P1196, DOI 10.1016/j.jhep.2006.03.005
   Meisinger C, 2005, J INTERN MED, V258, P527, DOI 10.1111/j.1365-2796.2005.01572.x
   Morrison JA, 1999, CIRCULATION, V100, P2244, DOI 10.1161/01.CIR.100.22.2244
   Nappi AJ, 1997, BBA-GEN SUBJECTS, V1336, P295, DOI 10.1016/S0304-4165(97)00039-1
   Ninomiya JK, 2004, CIRCULATION, V109, P42, DOI 10.1161/01.CIR.0000108926.04022.0C
   Onat A, 2006, PREV MED, V43, P136, DOI 10.1016/j.ypmed.2006.04.005
   Pagano G, 2002, HEPATOLOGY, V35, P367, DOI 10.1053/jhep.2002.30690
   Paolicchi A, 1999, J INVEST MED, V47, P151
   Paolicchi A, 2006, ATHEROSCLEROSIS, V186, P80, DOI 10.1016/j.atherosclerosis.2005.07.012
   Paolicchi A, 2004, CIRCULATION, V109, P1440, DOI 10.1161/01.CIR.0000120558.41356.E6
   Paolicchi A, 2002, BIOCHEM PHARMACOL, V64, P1027, DOI 10.1016/S0006-2952(02)01173-5
   Pastore A, 2003, CLIN CHIM ACTA, V333, P19, DOI 10.1016/S0009-8981(03)00200-6
   Piton A, 1998, HEPATOLOGY, V27, P1213, DOI 10.1002/hep.510270505
   Rashid S, 2003, CLIN BIOCHEM, V36, P421, DOI 10.1016/S0009-9120(03)00078-X
   Ruttmann E, 2005, CIRCULATION, V112, P2130, DOI 10.1161/CIRCULATIONAHA.105.552547
   Sakuta H, 2005, INTERNAL MED, V44, P538, DOI 10.2169/internalmedicine.44.538
   Semenkovich CF, 2006, J CLIN INVEST, V116, P1813, DOI 10.1172/JCI29024
   SHAW LM, 1979, CLIN CHEM, V25, P75
   Stocker R, 2004, PHYSIOL REV, V84, P1381, DOI 10.1152/physrev.00047.2003
   Stranges S, 2004, HEPATOLOGY, V39, P754, DOI 10.1002/hep.20149
   Urakawa H, 2003, J CLIN ENDOCR METAB, V88, P4673, DOI 10.1210/jc.2003-030202
   Van Gaal LF, 2006, NATURE, V444, P875, DOI 10.1038/nature05487
   WANNAMETHEE G, 1995, AM J EPIDEMIOL, V142, P699, DOI 10.1093/oxfordjournals.aje.a117699
   Whitfield JB, 2001, CRIT REV CL LAB SCI, V38, P263, DOI 10.1080/20014091084227
   Wu GY, 2004, J NUTR, V134, P489, DOI 10.1093/jn/134.10.2783S
NR 56
TC 45
Z9 49
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD MAR
PY 2008
VL 28
IS 3
BP 587
EP 593
DI 10.1161/ATVBAHA.107.157891
PG 7
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 266IZ
UT WOS:000253429000037
PM 18202323
OA Bronze
DA 2025-06-11
ER

PT J
AU Janicke, DM
   Harman, JS
   Kelleher, KJ
   Zhang, JY
AF Janicke, David M.
   Harman, Jeffrey S.
   Kelleher, Kelly J.
   Zhang, Jianyi
TI Psychiatric diagnosis in children and adolescents with obesity-related
   health conditions
SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
LA English
DT Article
DE children; obesity; psychiatric diagnosis; chronic illness
ID PSYCHOLOGICAL ADJUSTMENT; PSYCHOSOCIAL ADJUSTMENT; GLUCOSE-METABOLISM;
   DIABETES-MELLITUS; PHYSICAL-ACTIVITY; WEIGHT STATUS; YOUNG-ADULTS;
   RISK-FACTORS; CARE USE; OVERWEIGHT
AB Objective: Childhood obesity is linked with a number of problematic health conditions. While data suggest that children who are obese are at increased risk of psychosocial distress relative to nonobese peers, there are limited data outlining the rates of psychiatric diagnoses in children with obesity-related health conditions such as type 2 diabetes and the metabolic syndrome. Methods: This study used Medicaid claims data from the State of Florida to compare the rates of psychiatric diagnoses for children with obesity-related health conditions, aged 5 to 18 years, to those of children with comparison chronic health conditions. Results: Overall, 35% of children with an obesity-related diagnosis had a psychiatric diagnosis. While controlling for age, gender, and race, youths with type 2 diabetes, the metabolic syndrome, and dyslipidemia had higher rates of International Classification of Disease, Ninth Revision (ICD-9) psychiatric diagnoses than children with cystic fibrosis, sickle cell disease, and juvenile rheumatoid arthritis (p < .001), but similar to those of children with asthma. Non-Hispanic white children with an obesity-related health condition had greater odds of receiving a psychiatric diagnosis than African American (odds ratio [OR] = 0.54, p < .001) or Hispanic (OR = 0.41, p < .001) children. Males and females differed in rates of externalizing and internalizing diagnoses. Conclusions:The data suggest that children with an obesity-related health condition have higher rates of internalizing and externalizing mental health conditions relative to children with other chronic health conditions. Prospective, longitudinal research is needed to further confirm these findings and examine factors that affect this association and potential impacts on the health care system.
C1 [Janicke, David M.] Univ Florida, Dept Clin & Hlth Psychol, Gainesville, FL 32610 USA.
   [Harman, Jeffrey S.] Univ Florida, Dept Hlth Serv Res Management & Policy, Gainesville, FL 32610 USA.
   [Kelleher, Kelly J.] Childrens Hosp, Dept Pediat & Publ Hlth, Columbus, OH 43205 USA.
   [Zhang, Jianyi] Univ Florida, Ctr Medicaid & Uninsured, Gainesville, FL 32610 USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida; University System
   of Ohio; Ohio State University; Nationwide Childrens Hospital; State
   University System of Florida; University of Florida
RP Janicke, DM (corresponding author), Univ Florida, Dept Clin & Hlth Psychol, POB 100165, Gainesville, FL 32610 USA.
EM djanicke@phhp.ufl.edu
RI Kelleher, Kelly/E-3361-2011
OI Zhang, Jianyi/0000-0002-1501-4822; Janicke, David/0000-0002-8493-610X
CR BROWNBRIDGE G, 1994, PEDIATR NEPHROL, V8, P744, DOI 10.1007/BF00869109
   Cooper-Patrick L, 1999, JAMA-J AM MED ASSOC, V282, P583, DOI 10.1001/jama.282.6.583
   Correll CU, 2008, J AM ACAD CHILD PSY, V47, P9, DOI 10.1097/chi.0b013e31815b5cb1
   Dilley KJ, 2007, PEDIATRICS, V119, pE148, DOI 10.1542/peds.2005-2867
   DORSEY KB, 2007, ARCH PEDIAT ADOLESC, V159, P632
   Duncan GE, 2004, DIABETES CARE, V27, P2438, DOI 10.2337/diacare.27.10.2438
   Fagot-Campagna A, 2000, J PEDIATR-US, V136, P664, DOI 10.1067/mpd.2000.105141
   Falkner NH, 2001, OBES RES, V9, P32, DOI 10.1038/oby.2001.5
   Field AE, 2005, OBES RES, V13, P163, DOI 10.1038/oby.2005.21
   Freedman DS, 1999, PEDIATRICS, V103, P1175, DOI 10.1542/peds.103.6.1175
   GUO JH, 1994, ACTA PETROL SIN, V11, P1
   Hampl SE, 2007, ARCH PEDIAT ADOL MED, V161, P11, DOI 10.1001/archpedi.161.1.11
   Henderson DC, 2005, ARCH GEN PSYCHIAT, V62, P19, DOI 10.1001/archpsyc.62.1.19
   Janicke DM, 2001, MED CARE, V39, P990, DOI 10.1097/00005650-200109000-00009
   Janssen I, 2004, PEDIATRICS, V113, P1187, DOI 10.1542/peds.113.5.1187
   Johnson RL, 2004, AM J PUBLIC HEALTH, V94, P2084, DOI 10.2105/AJPH.94.12.2084
   Kelly DL, 1998, J CHILD ADOL PSYCHOP, V8, P151, DOI 10.1089/cap.1998.8.151
   KOVACS M, 1992, J AM ACAD CHILD PSY, V31, P1112, DOI 10.1097/00004583-199211000-00020
   LAVIGNE JV, 1992, J PEDIATR PSYCHOL, V17, P133, DOI 10.1093/jpepsy/17.2.133
   Lavigne JV, 1998, J AM ACAD CHILD PSY, V37, P262, DOI 10.1097/00004583-199803000-00010
   McQuaid EL, 2001, J DEV BEHAV PEDIATR, V22, P430, DOI 10.1097/00004703-200112000-00011
   O'Brien SH, 2004, PEDIATRICS, V114, P154, DOI 10.1542/peds.114.2.e154
   Ogden CL, 2006, JAMA-J AM MED ASSOC, V295, P1549, DOI 10.1001/jama.295.13.1549
   Rapoff M., 2003, HDB PEDIAT PSYCHOL, V3rd, P392
   Rhodes ET, 2007, DIABETES CARE, V30, P141, DOI 10.2337/dc06-1142
   Sallis JF, 2000, MED SCI SPORT EXER, V32, P963, DOI 10.1097/00005768-200009000-00012
   SATCHER S, 1999, 92 ANN NAACP CONV NE
   Scheen AJ, 2007, DIABETES METAB, V33, P169, DOI 10.1016/j.diabet.2007.01.003
   Schwimmer JB, 2003, JAMA-J AM MED ASSOC, V289, P1813, DOI 10.1001/jama.289.14.1813
   Sjöberg RL, 2005, PEDIATRICS, V116, pE389, DOI 10.1542/peds.2005-0170
   SMOAK CG, 1987, AM J EPIDEMIOL, V125, P364, DOI 10.1093/oxfordjournals.aje.a114543
   Storch EA, 2007, J PEDIATR PSYCHOL, V32, P80, DOI 10.1093/jpepsy/jsj113
   Thompson RJ, 1998, J CLIN PSYCHOL, V54, P121, DOI 10.1002/(SICI)1097-4679(199801)54:1<121::AID-JCLP14>3.3.CO;2-G
   Wei JN, 2003, JAMA-J AM MED ASSOC, V290, P1345, DOI 10.1001/jama.290.10.1345
   Weiss R, 2004, NEW ENGL J MED, V350, P2362, DOI 10.1056/NEJMoa031049
   Welch C, 2004, J AM DIET ASSOC, V104, P1080, DOI 10.1016/j.jada.2004.04.019
   White MA, 2005, INT J EAT DISORDER, V38, P78, DOI 10.1002/eat.20142
   Woolford SJ, 2007, OBESITY, V15, P1895, DOI 10.1038/oby.2007.224
   Zito JM, 1998, J CHILD ADOL PSYCHOP, V8, P99, DOI 10.1089/cap.1998.8.99
NR 39
TC 33
Z9 41
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0196-206X
EI 1536-7312
J9 J DEV BEHAV PEDIATR
JI J. Dev. Behav. Pediatr.
PD AUG
PY 2008
VL 29
IS 4
BP 276
EP 284
DI 10.1097/DBP.0b013e31817102f8
PG 9
WC Behavioral Sciences; Psychology, Developmental; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Psychology; Pediatrics
GA 337CA
UT WOS:000258411900008
PM 18562982
DA 2025-06-11
ER

PT J
AU Moorehead, NR
   Goodie, JL
   Krantz, DS
AF Moorehead, Nicholas R.
   Goodie, Jeffrey L.
   Krantz, David S.
TI Prospective Bidirectional Relations Between Depression and Metabolic
   Health: 30-Year Follow-Up From the National Heart, Lung, and Blood
   Institute (NHLBI) Coronary Artery Disease in Young Adults (CARDIA) Study
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE metabolic syndrome; depressive symptoms; race; sex; longitudinal study
ID RISK DEVELOPMENT; CIGARETTE-SMOKING; MAJOR DEPRESSION; UNITED-STATES;
   SYMPTOMS; ASSOCIATION; INFLAMMATION; POPULATION; OBESITY; SEX
AB Objective: This study investigated prospective bidirectional relationships between depressive symptoms and metabolic syndrome (MetS) and the moderating effects of race, sex, and health behaviors in a diverse cohort followed for 30 years. Method: Data were analyzed from the National Heart, Lung, and Blood Institute (NHLBI) Coronary Artery Disease in Young Adults (CARDIA) study, a 30-year prospective study of young adults (N = 5,113; M-age = 24.76 [SD = 3.63] at baseline; 45% male) who were tested every 5 years between 1985 and 2015. Measures included biological assessments of MetS components and self-reported depressive symptoms based on the Center for Epidemiologic Studies Depression (CESD) scale. Data analyses included bidirectional general estimating equations analyses of time-lagged associations between depressive symptoms and MetS. Results: There was a consistent, bidirectional relationship between depressive symptoms and MetS over time. Individuals with more CESD depressive symptoms were more likely to develop MetS over time compared to those reporting fewer symptoms, Wald chi(2)(1) = 7.09, p < .008, and MetS was similarly predictive of CESD. MetS more consistently predicted CESD scores at each 5-year exam than CESD predicted MetS. Race and sex moderated these relationships, with White females, White individuals overall, and females overall demonstrating significant relationships between CESD depressive symptoms and MetS. Health behaviors were not related to associations between CESD and MetS. Conclusion: In a diverse young adult population prospectively followed into late middle age, MetS more consistently predicted depressive symptoms over time than depressive symptoms predicted MetS. The relation between MetS and depressive symptoms was moderated by race and sex, but not health behaviors.
C1 [Moorehead, Nicholas R.] US Air Force, Eielson AFB, Operat Med Readiness Grp 354, 2630 Cent Ave, Eielson Afb, AK 99702 USA.
   [Moorehead, Nicholas R.; Goodie, Jeffrey L.; Krantz, David S.] Uniformed Serv Univ Hlth Sci, Sch Med, Dept Med & Clin Psychol, Bethesda, MD USA.
   [Goodie, Jeffrey L.] Uniformed Serv Univ Hlth Sci, Sch Med, Dept Family Med, Bethesda, MD USA.
C3 United States Department of Defense; United States Air Force; Uniformed
   Services University of the Health Sciences - USA; Uniformed Services
   University of the Health Sciences - USA
RP Moorehead, NR (corresponding author), US Air Force, Eielson AFB, Operat Med Readiness Grp 354, 2630 Cent Ave, Eielson Afb, AK 99702 USA.
EM nicholas.r.moorehead.mil@health.mil
RI Krantz, David/L-5364-2015; Goodie, Jeffrey/AAU-1318-2020
OI Krantz, David/0000-0002-1671-1355
CR Akbaraly TN, 2009, DIABETES CARE, V32, P499, DOI 10.2337/dc08-1358
   Bailey RK, 2019, NEUROPSYCH DIS TREAT, V15, P603, DOI 10.2147/NDT.S128584
   Bakhshaie J, 2015, COMPR PSYCHIAT, V60, P142, DOI 10.1016/j.comppsych.2014.10.012
   Beydoun MA, 2020, MOL PSYCHIATR, V25, P1286, DOI 10.1038/s41380-019-0408-2
   Boyle M, 2018, J HEPATOL, V68, P251, DOI 10.1016/j.jhep.2017.11.006
   Camhi SM, 2013, METAB SYNDR RELAT D, V11, P195, DOI 10.1089/met.2012.0120
   Capuron L, 2008, BIOL PSYCHIAT, V64, P896, DOI 10.1016/j.biopsych.2008.05.019
   Carnethon MR, 2004, DIABETES CARE, V27, P2707, DOI 10.2337/diacare.27.11.2707
   Carney RM, 2017, NAT REV CARDIOL, V14, DOI 10.1038/nrcardio.2016.181
   Chinn S, 2000, STAT MED, V19, P3127, DOI 10.1002/1097-0258(20001130)19:22<3127::AID-SIM784>3.0.CO;2-M
   Colen CG, 2018, SOC SCI MED, V199, P167, DOI 10.1016/j.socscimed.2017.04.051
   Cooper Denise C, 2013, Cardiovasc Psychiatry Neurol, V2013, P979185, DOI 10.1155/2013/979185
   Cosco TD, 2017, J NURS MEAS, V25, P476, DOI 10.1891/1061-3749.25.3.476
   Duffey KJ, 2010, AM J CLIN NUTR, V92, P954, DOI 10.3945/ajcn.2010.29478
   Foley DL, 2010, TWIN RES HUM GENET, V13, P347, DOI 10.1375/twin.13.4.347
   FRIEDMAN GD, 1988, J CLIN EPIDEMIOL, V41, P1105, DOI 10.1016/0895-4356(88)90080-7
   Funkhouser E, 2018, CONT CLIN TRIAL COMM, V9, P64, DOI 10.1016/j.conctc.2017.12.003
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Grenard JL, 2011, J GEN INTERN MED, V26, P1175, DOI 10.1007/s11606-011-1704-y
   Grundy SM, 2004, CIRCULATION, V110, P227, DOI 10.1161/01.CIR.0000133317.49796.0E
   Gurka MJ, 2014, METABOLISM, V63, P218, DOI 10.1016/j.metabol.2013.10.006
   Hargrove TW, 2020, J RACIAL ETHN HEALTH, V7, P619, DOI 10.1007/s40615-019-00692-8
   Harvey SB, 2018, AM J PSYCHIAT, V175, P28, DOI 10.1176/appi.ajp.2017.16111223
   Hiles SA, 2016, DEPRESS ANXIETY, V33, P754, DOI 10.1002/da.22512
   Hryhorczuk C, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00177
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Jacobs David R Jr, 1989, J Cardiopulm Rehabil, V9, P448, DOI 10.1097/00008483-198911000-00003
   Kessler RC, 2013, ANNU REV PUBL HEALTH, V34, P119, DOI 10.1146/annurev-publhealth-031912-114409
   Liaw FY, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/586251
   Ljungberg T, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17051616
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Mathew AR, 2017, ADDICTION, V112, P401, DOI 10.1111/add.13604
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   Moorehead N. R., 2023, THESIS UNIFORMED SER
   Moradi Yousef, 2021, Clin Diabetes Endocrinol, V7, P4, DOI 10.1186/s40842-021-00117-8
   Murphy MJ, 2015, SLEEP MED CLIN, V10, P17, DOI 10.1016/j.jsmc.2014.11.009
   Murri MB, 2019, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00762
   Needham BL, 2010, AM J PUBLIC HEALTH, V100, P1040, DOI 10.2105/AJPH.2009.172809
   NHLBI, 2021, CARDIA STUD OV
   Noonan AS, 2016, PUBLIC HEALTH REV, V37, DOI 10.1186/s40985-016-0025-4
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Sun K, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047791
   Sutin AR, 2013, JAMA PSYCHIAT, V70, P803, DOI 10.1001/jamapsychiatry.2013.193
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
   Vilagut G, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0155431
   Vishram JKK, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0107294
   Womack VY, 2016, PSYCHOSOM MED, V78, P867, DOI 10.1097/PSY.0000000000000347
   Ziki MDA, 2016, CURR OPIN LIPIDOL, V27, P162, DOI 10.1097/MOL.0000000000000276
NR 50
TC 2
Z9 2
U1 0
U2 39
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD APR
PY 2024
VL 43
IS 4
BP 259
EP 268
DI 10.1037/hea0001339
EA DEC 2023
PG 10
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA H7I7O
UT WOS:001126023600001
PM 38095973
DA 2025-06-11
ER

PT J
AU Enko, D
   Brandmayr, W
   Halwachs-Baumann, G
   Schnedl, WJ
   Meinitzer, A
   Kriegshäuser, G
AF Enko, Dietmar
   Brandmayr, Wolfgang
   Halwachs-Baumann, Gabriele
   Schnedl, Wolfgang J.
   Meinitzer, Andreas
   Kriegshaeuser, Gernot
TI Prospective plasma lipid profiling in individuals with and without
   depression
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Biomarkers; Cholesterol; Depression; Lipids; Triglycerides
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; SERUM-CHOLESTEROL; MAJOR
   DEPRESSION; CARDIOVASCULAR-DISEASE; BIPOLAR DISORDER; RISK-FACTOR; MEN;
   POPULATION; SYMPTOMS
AB Background: So far, studies on possible association of plasma lipid levels and depressive disorder are contradictory. This prospective work aimed at assessing a plasma lipid profile in individuals with major depression and healthy controls.
   Methods: In total, 94 patients with major depression and 152 healthy controls were included in this prospective study. After an overnight fasting state of 12 h they underwent blood drawing for triglyzerides (TG), total cholesterol, low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol measurements. All participants were evaluated in a clinical interview and filled out the self-rating Beck Depression Inventory (BDI-II) scale to identify depressive symptomatology.
   Results: Ninety-four patients with major depression showed significantly higher median (interquartile range) plasma TG levels (108.0 [75.8-154.1] vs. 84.0 [63.0-132.2] mg/dL, P = 0.014) and significantly lower HDL-cholesterol levels (55.0 [46.9-123.0] vs. 61.5 [47.4-72.6] mg/dL, P = 0.049) compared to 152 individuals without depression, respectively. Total and LDL-cholesterol concentrations were observed slightly higher in patients with major depression. Significant positive correlation was found between TG, total cholesterol and LDL-cholesterol concentrations and the BDI-II score (p = 0.027, 0.048 and 0.018), and in tendency negative correlation between HDL-cholesterol levels and the BDI-II score (P = 0.091), respectively.
   Conclusions: Depressive individuals were found with adverse plasma lipid patterns of higher TG and lower HDL-cholesterol levels compared to healthy controls. On this basis, the authors would suggest the implementation of routine lipid measurements in order to stratify these patients by their cardiovascular risk.
C1 [Enko, Dietmar; Halwachs-Baumann, Gabriele; Kriegshaeuser, Gernot] Gen Hosp Steyr, Inst Clin Chem & Lab Med, Sierningerstr 170, A-400 Steyr, Austria.
   [Enko, Dietmar; Meinitzer, Andreas; Kriegshaeuser, Gernot] Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Auenbruggerpl 15, A-8036 Graz, Austria.
   [Brandmayr, Wolfgang] Gen Hosp Steyr, Dept Psychiat & Psychotherapeut Med, Sierningerstr 170, A-400 Steyr, Austria.
   [Schnedl, Wolfgang J.] Practice Gen Internal Med, Dr Theodor Korner Str 19b, A-8600 Bruck Mur, Austria.
C3 Medical University of Graz
RP Enko, D (corresponding author), Gen Hosp Steyr, Inst Clin Chem & Lab Med, Sierningerstr 170, A-400 Steyr, Austria.; Enko, D (corresponding author), Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Auenbruggerpl 15, A-8036 Graz, Austria.
EM dietmar.enko@gespag.at
OI Schnedl, Wolfgang/0000-0002-5212-5230
CR Äijänseppä S, 2002, INT J GERIATR PSYCH, V17, P629, DOI 10.1002/gps.666
   Atlantis E, 2011, SOC PSYCH PSYCH EPID, V46, P1303, DOI 10.1007/s00127-010-0302-3
   Barth J, 2004, PSYCHOSOM MED, V66, P802, DOI 10.1097/01.psy.0000146332.53619.b2
   Beck A. T., 1996, BDI 2 BECK DEPRESSIO
   Beydoun MA, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.4
   Dortland AKBV, 2010, J CLIN PSYCHIAT, V71, P729, DOI 10.4088/JCP.08m04865blu
   Elovainio M, 2010, HEALTH PSYCHOL, V29, P237, DOI 10.1037/a0018875
   Goldston K, 2008, CLIN PSYCHOL REV, V28, P288, DOI 10.1016/j.cpr.2007.05.005
   Ledochowski M, 2003, CLIN CHEM LAB MED, V41, P821, DOI 10.1515/CCLM.2003.124
   Lemche AV, 2017, J ENDOCRINOL INVEST, V40, P539, DOI 10.1007/s40618-016-0601-y
   Maes M, 1997, ACTA PSYCHIAT SCAND, V95, P212, DOI 10.1111/j.1600-0447.1997.tb09622.x
   Moreira FP, 2017, J PSYCHIATR RES, V92, P119, DOI 10.1016/j.jpsychires.2017.03.025
   Nakao M, 2004, TOHOKU J EXP MED, V204, P273, DOI 10.1620/tjem.204.273
   Nelson RH, 2013, PRIMARY CARE, V40, P195, DOI 10.1016/j.pop.2012.11.003
   Nordestgaard BG, 2014, LANCET, V384, P626, DOI 10.1016/S0140-6736(14)61177-6
   Oh J, 2017, J AFFECT DISORDERS, V213, P51, DOI 10.1016/j.jad.2017.02.002
   Olusi SO, 1996, BIOL PSYCHIAT, V40, P1128, DOI 10.1016/S0006-3223(95)00599-4
   Ong KL, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.232
   Sauer WH, 2001, CIRCULATION, V104, P1894, DOI 10.1161/hc4101.097519
   Shao TN, 2017, COMPR PSYCHIAT, V75, P103, DOI 10.1016/j.comppsych.2017.03.007
   Steer RA, 1999, J CLIN PSYCHOL, V55, P117, DOI 10.1002/(SICI)1097-4679(199901)55:1<117::AID-JCLP12>3.0.CO;2-A
   Tedders SH, 2011, J AFFECT DISORDERS, V135, P115, DOI 10.1016/j.jad.2011.06.045
   Nunes SOV, 2015, J AFFECT DISORDERS, V172, P55, DOI 10.1016/j.jad.2014.09.038
   Virtanen M, 2017, J CLIN PSYCHIAT, V78, pE1, DOI 10.4088/JCP.15m10399
   Welty FK, 2013, CURR CARDIOL REP, V15, DOI 10.1007/s11886-013-0400-4
   Xu C, 2009, MOL ENDOCRINOL, V23, P1161, DOI 10.1210/me.2008-0464
NR 26
TC 49
Z9 52
U1 1
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD JUN 26
PY 2018
VL 17
AR 149
DI 10.1186/s12944-018-0796-3
PG 6
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA GL2WE
UT WOS:000436985800001
PM 29945617
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ayuthaya, BIN
   Lertpimonchai, A
   Samaranayake, L
   Vathesatogkit, P
   Thienpramuk, L
   Wisitrasameewong, W
   Tamsailom, S
AF Ayuthaya, Benjar Issaranggun Na
   Lertpimonchai, Attawood
   Samaranayake, Lakshman
   Vathesatogkit, Prin
   Thienpramuk, Lalitsara
   Wisitrasameewong, Wichaya
   Tamsailom, Suphot
TI The Potential Effect of Periodontal Disease on the Development of
   Metabolic Syndrome: A 10-Year Observational Study in a Thai Adult Cohort
SO JOURNAL OF CLINICAL PERIODONTOLOGY
LA English
DT Article
DE longitudinal studies; metabolic syndrome; periodontal diseases;
   periodontitis
ID CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; ASSOCIATION; PREVALENCE;
   INFLAMMATION; POPULATION; SURVEILLANCE; MARKERS; RISK; AGE
AB AimAs data are sparse on the long-term association between periodontal diseases and development of metabolic syndrome (MetS), we investigated their relationship in a Thai cohort over a 10-year observational period.MethodsMedical records and data on periodontal assessments of 2161 employees of the Electricity Generating Authority of Thailand collected at two time points, 2003 and 2013, were used. Experienced periodontists used standard national and international criteria to define periodontitis and MetS. The impact of baseline periodontitis on subsequent MetS incidence and its components was evaluated using regression analyses.ResultsThe severity and extent of periodontitis significantly predicted MetS incidence over a decade, with a higher incidence of MetS in individuals with poorer periodontal health. A single percentage increase in the periodontitis extent raised the risk of MetS incidence by 0.4% and the risk of developing individual components of MetS by 0.2%. Independent of periodontal health, age of an individual emerged as a factor impacting MetS development.ConclusionThis study highlights the potential effect of the severity and extent of periodontitis on the increased incidence and progression of MetS. Hyperglycaemia and hypertension were the two MetS components most significantly affected by the existence of periodontitis.
C1 [Ayuthaya, Benjar Issaranggun Na; Lertpimonchai, Attawood; Samaranayake, Lakshman; Wisitrasameewong, Wichaya; Tamsailom, Suphot] Chulalongkorn Univ, Fac Dent, Ctr Excellence Periodontal Dis & Implant Dent, Dept Periodontol, Bangkok, Thailand.
   [Samaranayake, Lakshman] Univ Hong Kong, Fac Dent, Pok Fu Lam, Hong Kong, Peoples R China.
   [Vathesatogkit, Prin] Mahidol Univ, Ramathibodi Hosp, Fac Med, Bangkok, Thailand.
   [Thienpramuk, Lalitsara] Elect Generating Author Thailand, Med & Hlth Dept, Hlth Div, Nonthaburi, Thailand.
C3 Chulalongkorn University; University of Hong Kong; Mahidol University
RP Tamsailom, S (corresponding author), Chulalongkorn Univ, Fac Dent, Ctr Excellence Periodontal Dis & Implant Dent, Dept Periodontol, Bangkok, Thailand.
EM suphot.t@chula.ac.th
RI Samaranayake, Lakshman/K-4947-2018
OI Lertpimonchai, Attawood/0000-0003-2501-1534; Tamsailom,
   Suphot/0000-0001-6843-5885
FU Thailand Research Fund; Chulalongkorn Academic Advancement into its 2nd
   Century Project (CUAASC); Thai Health Promotion Foundation [99/8];
   Chulalongkorn University, second century (C2) high potential
   professoriate fund at its Faculty of Dentistry
FX We would like to thank the staff of Ramathibodi Hospital and the
   Department of Periodontology, Chulalongkorn University, who contributed
   to the survey and data collection Additionally, we extend our thanks to
   Associate Prof. Orawan Charatkulangkun and Prof. Piyamitr Sritara for
   their valuable contributions to study design and data interpretation.
   This study was supported by the Chulalongkorn Academic Advancement into
   its 2nd Century Project (CUAASC) (Chamchuri 5 Building 6th Floor,
   Phayathai Road, Pathumwan, Bangkok 10330, Thailand), Thailand Research
   Fund and Thai Health Promotion Foundation (Thai Health Centre, 99/8, Soi
   Ngamduplee, Thung Maha Mek, Sathorn, Bangkok 10120, Thailand). Lakshman
   Samaranayake was supported by the Chulalongkorn University, second
   century (C2) high potential professoriate fund at its Faculty of
   Dentistry.
CR Adachi N, 2020, J ORAL SCI, V62, P52, DOI 10.2334/josnusd.18-0251
   Alhabashneh R, 2015, J DIABETES METAB DIS, V14, DOI 10.1186/s40200-015-0192-8
   [Anonymous], 2001, JAMA, V285, P2486, DOI DOI 10.1001/JAMA.285.19.2486
   BAELUM V, 1993, COMMUNITY DENT ORAL, V21, P354, DOI 10.1111/j.1600-0528.1993.tb01098.x
   BODEN G, 1993, DIABETES CARE, V16, P728, DOI 10.2337/diacare.16.5.728
   Bullon P, 2009, J DENT RES, V88, P503, DOI 10.1177/0022034509337479
   Charupinijkul A, 2022, CLIN ORAL INVEST, V26, P535, DOI 10.1007/s00784-021-04031-2
   D'Aiuto F, 2008, J CLIN ENDOCR METAB, V93, P3989, DOI 10.1210/jc.2007-2522
   Dental Health Division, 2018, REPORT 8 NATL ORAL H
   Eke PI, 2018, J AM DENT ASSOC, V149, P576, DOI 10.1016/j.adaj.2018.04.023
   Eke PI, 2012, J PERIODONTOL, V83, P1449, DOI 10.1902/jop.2012.110664
   Eke PI, 2012, J PERIODONTOL, V83, P1337, DOI 10.1902/jop.2012.110676
   Fukui N, 2012, J PERIODONTOL, V83, P1363, DOI 10.1902/jop.2012.110605
   Han DH, 2010, J CLIN PERIODONTOL, V37, P609, DOI 10.1111/j.1600-051X.2010.01580.x
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Khader Y, 2008, J PERIODONTOL, V79, P2048, DOI [10.1902/jop.2008.080022, 10.1902/jop.2008.080022 ]
   Klein BEK, 2002, DIABETES CARE, V25, P1790, DOI 10.2337/diacare.25.10.1790
   Lamster IB, 2017, INT DENT J, V67, P67, DOI 10.1111/idj.12264
   Li P, 2009, J PERIODONTOL, V80, P541, DOI 10.1902/jop.2009.080387
   Li Y, 2015, J DENT RES, V94, P362, DOI 10.1177/0022034514561658
   Lin KM, 2019, BIOL RES NURS, V21, P173, DOI 10.1177/1099800418816175
   Liu Ying, 2017, Prev Med Rep, V7, P193, DOI 10.1016/j.pmedr.2017.06.010
   Loos BG, 2000, J PERIODONTOL, V71, P1528, DOI 10.1902/jop.2000.71.10.1528
   Marcenes W, 2013, J DENT RES, V92, P592, DOI 10.1177/0022034513490168
   Martínez-Montoro JI, 2023, OBES REV, V24, DOI 10.1111/obr.13599
   Morita T, 2010, J PERIODONTOL, V81, P512, DOI 10.1902/jop.2010.090594
   Nibali L, 2007, J CLIN PERIODONTOL, V34, P931, DOI 10.1111/j.1600-051X.2007.01133.x
   Nibali L, 2013, J CLIN ENDOCR METAB, V98, P913, DOI 10.1210/jc.2012-3552
   Ortigara GB, 2021, J CLIN PERIODONTOL, V48, P886, DOI 10.1111/jcpe.13462
   Park D, 2023, JACC-ASIA, V3, P491, DOI 10.1016/j.jacasi.2023.02.007
   Ranasinghe P, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4041-1
   Saito M, 2024, J CLIN PERIODONTOL, V51, P54, DOI 10.1111/jcpe.13881
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sakurai S, 2019, J PERIODONTOL, V90, P728, DOI 10.1002/JPER.18-0523
   Sakurai T, 2010, GERONTOLOGY, V56, P141, DOI 10.1159/000246970
   Shimada Y, 2010, J PERIODONTOL, V81, P1118, DOI 10.1902/jop.2010.090741
   Shin HS, 2018, ASIA-PAC J PUBLIC HE, V30, P415, DOI 10.1177/1010539518786517
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Suwanprasit W, 2021, J PERIODONTOL, V92, P1420, DOI 10.1002/JPER.20-0651
   Tan CE, 2004, DIABETES CARE, V27, P1182, DOI 10.2337/diacare.27.5.1182
   Tonetti MS, 2018, J CLIN PERIODONTOL, V45, pS149, DOI [10.1111/jcpe.12945, 10.1002/JPER.18-0006]
   Tonetti MS, 2013, J CLIN PERIODONTOL, V40, pS24, DOI 10.1111/jcpe.12089
   Torumtay G, 2016, J PERIODONTAL RES, V51, P489, DOI 10.1111/jre.12328
   Tucker JM, 2016, AM J HEALTH PROMOT, V30, P155, DOI 10.4278/ajhp.121127-QUAN-576
   Vajdi M, 2023, BMC ENDOCR DISORD, V23, DOI 10.1186/s12902-023-01270-0
   Vancampfort D, 2016, ALCOHOL ALCOHOLISM, V51, P515, DOI 10.1093/alcalc/agw040
   Vathesatogkit P, 2012, INT J EPIDEMIOL, V41, P359, DOI 10.1093/ije/dyq218
   Yuenyongchaiwat K., 2017, Songklanakarin Journal of Science and Technology, V39, P787
NR 48
TC 3
Z9 3
U1 1
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-6979
EI 1600-051X
J9 J CLIN PERIODONTOL
JI J. Clin. Periodontol.
PD MAR
PY 2025
VL 52
IS 3
BP 339
EP 352
DI 10.1111/jcpe.14068
EA SEP 2024
PG 14
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA X1J5E
UT WOS:001308945200001
PM 39256912
OA hybrid
DA 2025-06-11
ER

PT J
AU Deng, ZZ
   Wang, J
   Wu, N
   Geng, LH
   Zhang, QB
   Yue, Y
AF Deng, Zhenzhen
   Wang, Jing
   Wu, Ning
   Geng, Lihua
   Zhang, Quanbin
   Yue, Yang
TI Co-activating the AMPK signaling axis by low molecular weight fucoidan
   LF2 and fucoxanthin improves the HFD-induced metabolic syndrome in mice
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Fucoxanthin; Fucoidan; Metabolic Syndrome; AMPK Signaling Axis
ID INSULIN-RESISTANCE; DOWN-REGULATION; ADIPOCYTE DIFFERENTIATION; FATTY
   LIVER; PPAR-GAMMA; ADIPOGENESIS; GLUCOSE; MODEL; DIET
AB Metabolic syndrome (MetS) is a pathological condition characterized by multiple metabolic abnormalities. With the global epidemic of obesity and diabetes, MetS needs more urgent treatments and interventions. Fucoxanthin (FX) and fucoidan are two important active components derived from brown algae, which have been recommended as adjunctive therapy for MetS. In this study, we found that FX and low molecular weight fucoidan fraction LF2 improved insulin resistance (IR) and enhanced insulin sensitivity in high fat diet (HFD)-induced MetS mice synergistically. LF2 and FX could ameliorate HFD-induced liver injury by reducing liver fat deposition, inflammatory response and oxidative stress. Adenosine 5'-monophosphate-activated protein kinase (AMPK) signaling axis is a key target for LF2 and FX to improve MetS. FX and LF2 reduced adipogenesis and conversion through co-activation of AMPK and reduction of the expression of adipogenic differentiation factors. In addition, FX up-regulated the expression of uncoupling protein (UCP-1) and promoted the body's energy expenditure. However, LF2 did not significantly increase the anti-hyperlipidemic effect of FX. Collectively, this study elucidated the synergistic improvement of MetS by FX and LF2 from a molecular perspective. It also demonstrated the potential of fucoxanthin combined with fucoidan as an anti-MetS functional food.
C1 [Deng, Zhenzhen; Wang, Jing; Wu, Ning; Geng, Lihua; Zhang, Quanbin; Yue, Yang] Inst Oceanol, Chinese Acad Sci, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China.
   [Deng, Zhenzhen; Wang, Jing; Wu, Ning; Geng, Lihua; Zhang, Quanbin; Yue, Yang] Lab Marine Biol & Biotechnol, Qingdao Natl Lab Marine Sci & Tech, Qingdao 266071, Peoples R China.
   [Deng, Zhenzhen; Zhang, Quanbin] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
   [Deng, Zhenzhen; Wang, Jing; Wu, Ning; Geng, Lihua; Zhang, Quanbin; Yue, Yang] Chinese Acad Sci, CAS, Qingdao 266071, Peoples R China.
C3 Chinese Academy of Sciences; Institute of Oceanology, CAS; Laoshan
   Laboratory; Chinese Academy of Sciences; University of Chinese Academy
   of Sciences, CAS; Chinese Academy of Sciences
RP Yue, Y (corresponding author), Inst Oceanol, Chinese Acad Sci, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China.; Yue, Y (corresponding author), Chinese Acad Sci, CAS, Qingdao 266071, Peoples R China.
EM yueyang@qdio.ac.cn
RI Zhang, Quanbin/IUQ-3663-2023
CR Asrih M, 2015, MOL CELL ENDOCRINOL, V418, P55, DOI 10.1016/j.mce.2015.02.018
   Bae M, 2020, BBA-MOL CELL BIOL L, V1865, DOI 10.1016/j.bbalip.2020.158618
   Beppu F, 2013, LIPIDS, V48, P449, DOI 10.1007/s11745-013-3784-4
   Chang PM, 2019, MAR DRUGS, V17, DOI 10.3390/md17010069
   Chang YH, 2018, BIOCHEM BIOPH RES CO, V495, P197, DOI 10.1016/j.bbrc.2017.11.022
   Cho M, 2014, CARBOHYD POLYM, V113, P507, DOI 10.1016/j.carbpol.2014.07.055
   Choi KM, 2014, FOOD SCI BIOTECHNOL, V23, P931, DOI 10.1007/s10068-014-0125-1
   Cumashi A, 2007, GLYCOBIOLOGY, V17, P541, DOI 10.1093/glycob/cwm014
   den Besten G, 2013, J LIPID RES, V54, P2325, DOI 10.1194/jlr.R036012
   Deng ZZ, 2021, INT J BIOL MACROMOL, V193, P789, DOI 10.1016/j.ijbiomac.2021.10.188
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Fraulob JC, 2010, J CLIN BIOCHEM NUTR, V46, P212, DOI 10.3164/jcbn.09-83
   Galisteo M, 2008, J NUTR BIOCHEM, V19, P71, DOI 10.1016/j.jnutbio.2007.02.009
   Grasa-López A, 2016, MAR DRUGS, V14, DOI 10.3390/md14080148
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Hong SY, 2021, NUTR RES PRACT, V15, P444, DOI 10.4162/nrp.2021.15.4.444
   Kang SI, 2011, BIOCHEM BIOPH RES CO, V409, P769, DOI 10.1016/j.bbrc.2011.05.086
   Khanal RC, 2012, J MED FOOD, V15, P802, DOI 10.1089/jmf.2011.0212
   Koo SY, 2019, MAR DRUGS, V17, DOI 10.3390/md17050311
   Kotronen A, 2008, ARTERIOSCL THROM VAS, V28, P27, DOI 10.1161/ATVBAHA.107.147538
   Kylin E, 1923, STUDIEN HYPERTONIE H
   Lai CS, 2012, J AGR FOOD CHEM, V60, P1094, DOI 10.1021/jf204862d
   Lidfeldt J, 2003, DIABETES OBES METAB, V5, P106, DOI 10.1046/j.1463-1326.2003.00250.x
   Lin HTV, 2017, MAR DRUGS, V15, DOI 10.3390/md15040113
   Maeda H, 2006, INT J MOL MED, V18, P147
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Moghadamtousi SZ, 2014, SCI WORLD J, DOI 10.1155/2014/768323
   Muradian K, 2015, NUTR METAB CARDIOVAS, V25, P891, DOI 10.1016/j.numecd.2015.05.010
   Nishikawa S, 2012, PHYTOMEDICINE, V19, P389, DOI 10.1016/j.phymed.2011.11.001
   Rosen ED, 2006, NAT REV MOL CELL BIO, V7, P885, DOI 10.1038/nrm2066
   Sharma PP, 2021, ALGAL RES, V54, DOI 10.1016/j.algal.2021.102187
   Shih PH, 2021, MAR DRUGS, V19, DOI 10.3390/md19030148
   Vo TS, 2013, J FUNCT FOODS, V5, P16, DOI 10.1016/j.jff.2012.08.007
   Tholpady SS, 2005, ANN PLAS SURG, V54, P651, DOI 10.1097/01.sap.0000158065.12174.40
   Wang J, 2020, INT J BIOL MACROMOL, V150, P304, DOI 10.1016/j.ijbiomac.2020.02.087
   Wang J, 2010, INT J BIOL MACROMOL, V47, P126, DOI 10.1016/j.ijbiomac.2010.05.010
   Yim MJ, 2011, J AGR FOOD CHEM, V59, P1646, DOI 10.1021/jf103290f
   Yin JY, 2019, J FUNCT FOODS, V61, DOI 10.1016/j.jff.2019.103493
   Zhang Q.-B., 2019, MAR SCI-CHINA, V43, P67, DOI [10.11759/hykx20190308001, DOI 10.11759/HYKX20190308001]
   Zhang YP, 2018, J FUNCT FOODS, V48, P515, DOI 10.1016/j.jff.2018.07.048
   Zheng YY, 2018, INT J BIOL MACROMOL, V112, P929, DOI 10.1016/j.ijbiomac.2018.02.072
NR 41
TC 2
Z9 2
U1 5
U2 38
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JUL
PY 2022
VL 94
AR 105119
DI 10.1016/j.jff.2022.105119
EA MAY 2022
PG 9
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 1Y0QN
UT WOS:000807851100001
OA gold
DA 2025-06-11
ER

PT J
AU Navarrete, C
   Garcia-Martin, A
   DeMesa, J
   Muñoz, E
AF Navarrete, Carmen
   Garcia-Martin, Adela
   DeMesa, Jim
   Munoz, Eduardo
TI Cannabinoids in Metabolic Syndrome and Cardiac Fibrosis
SO CURRENT HYPERTENSION REPORTS
LA English
DT Review
DE Cannabinoids; Endocannabinoid system; Metabolic syndrome; Cardiovascular
   disease; Cardiac fibrosis
ID RECEPTOR ANTAGONIST TM38837; MUSCLE-CELL PROLIFERATION; ENDOCANNABINOID
   SYSTEM; MOLECULAR CHARACTERIZATION; MYOCARDIAL-INFARCTION; MONOGLYCERIDE
   LIPASE; OXIDATIVE STRESS; GENETIC ABLATION; INFLAMMATION; INHIBITION
AB Purpose of Review This article provides a concise overview of how cannabinoids and the endocannabinoid system (ECS) have significant implications for the prevention and treatment of metabolic syndrome (MetS) and for the treatment of cardiovascular disorders, including cardiac fibrosis. Recent Findings Over the past few years, the ECS has emerged as a pivotal component of the homeostatic mechanisms for the regulation of many bodily functions, including inflammation, digestion, and energy metabolism. Therefore, the pharmacological modulation of the ECS by cannabinoids represents a novel strategy for the management of many diseases. Specifically, increasing evidence from preclinical research studies has opened new avenues for the development of cannabinoid-based therapies for the management and potential treatment of MetS and cardiovascular diseases. Current information indicates that modulation of the ECS can help maintain overall health and well-being due to its homeostatic function. From a therapeutic perspective, cannabinoids and the ECS have also been shown to play a key role in modulating pathophysiological states such as inflammatory, neurodegenerative, gastrointestinal, metabolic, and cardiovascular diseases, as well as cancer and pain. Thus, targeting and modulating the ECS with cannabinoids or cannabinoid derivatives may represent a major disease-modifying medical advancement to achieve successful treatment for MetS and certain cardiovascular diseases.
C1 [Navarrete, Carmen; Garcia-Martin, Adela; DeMesa, Jim] Emerald Hlth Pharmaceut, San Diego, CA USA.
   [Munoz, Eduardo] Univ Cordoba, Inst Maimonides Invest Biomed Cordoba, Avda Menendez Pidal S-N, Cordoba 14004, Spain.
   [Munoz, Eduardo] Univ Cordoba, Dept Biol Celular Fisiol & Inmunol, Cordoba, Spain.
   [Munoz, Eduardo] Hosp Univ Reina Sofia, Cordoba, Spain.
C3 Universidad de Cordoba; Universidad de Cordoba; Hospital Universitario
   Reina Sofia - Cordoba
RP Muñoz, E (corresponding author), Univ Cordoba, Inst Maimonides Invest Biomed Cordoba, Avda Menendez Pidal S-N, Cordoba 14004, Spain.; Muñoz, E (corresponding author), Univ Cordoba, Dept Biol Celular Fisiol & Inmunol, Cordoba, Spain.; Muñoz, E (corresponding author), Hosp Univ Reina Sofia, Cordoba, Spain.
EM filmuble@uco.es
RI Munoz, Eduardo/I-5225-2012
OI Navarrete, Carmen Maria/0000-0003-1438-9216; GARCIA MARTIN, ADELA
   MARIA/0000-0001-7054-7907; Munoz, Eduardo/0000-0001-8478-5842
CR Alfulaij N, 2018, J AM HEART ASSOC, V7, DOI 10.1161/JAHA.118.009099
   Bazwinsky-Wutschke I, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20102516
   Brown SM, 2002, BBA-GENE STRUCT EXPR, V1576, P255, DOI 10.1016/S0167-4781(02)00341-X
   Carmona-Hidalgo BG-MI, 2020, 9 TETRAHYDROCANNABIN, DOI [10.1101/2020.05.11.088070, DOI 10.1101/2020.05.11.088070]
   Carrier EJ, 2006, P NATL ACAD SCI USA, V103, P7895, DOI 10.1073/pnas.0511232103
   Casares L, 2020, REDOX BIOL, V28, DOI 10.1016/j.redox.2019.101321
   Chang E, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0206152
   Cinar R, 2020, PHARMACOL THERAPEUT, V208, DOI 10.1016/j.pharmthera.2020.107477
   Cravatt BF, 1996, NATURE, V384, P83, DOI 10.1038/384083a0
   de Azua IR, 2019, CELL MOL LIFE SCI, V76, P1341, DOI 10.1007/s00018-018-2994-6
   de Azua IR, 2017, J CLIN INVEST, V127, P4148, DOI 10.1172/JCI83626
   del Río C, 2016, SCI REP-UK, V6, DOI 10.1038/srep21703
   DEVANE WA, 1992, SCIENCE, V258, P1946, DOI 10.1126/science.1470919
   Di Marzo V, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081956
   Di Marzo V, 2018, NAT REV DRUG DISCOV, V17, P623, DOI 10.1038/nrd.2018.115
   Dinh TP, 2002, CHEM PHYS LIPIDS, V121, P149, DOI 10.1016/S0009-3084(02)00150-0
   Duerr GD, 2019, J MOL CELL CARDIOL, V133, P86, DOI 10.1016/j.yjmcc.2019.06.003
   Duerr GD, 2018, LIFE SCI, V215, P96, DOI 10.1016/j.lfs.2018.11.003
   Eid Basma Ghazi, 2018, J Microsc Ultrastruct, V6, P171, DOI 10.4103/JMAU.JMAU_42_18
   Fulmer Makenzie L., 2018, Cardiovascular & Hematological Disorders - Drug Targets, V18, P34, DOI 10.2174/1871529X18666180206161457
   GAONI Y, 1971, J AM CHEM SOC, V93, P217, DOI 10.1021/ja00730a036
   García-Martín A, 2019, BIOCHEM PHARMACOL, V163, P321, DOI 10.1016/j.bcp.2019.02.029
   García-Martín A, 2018, BIOCHEM PHARMACOL, V157, P304, DOI 10.1016/j.bcp.2018.07.047
   Gil-Ordóñez A, 2018, BIOCHEM PHARMACOL, V157, P18, DOI 10.1016/j.bcp.2018.07.036
   Grabner GF, 2017, PHARMACOL THERAPEUT, V175, P35, DOI 10.1016/j.pharmthera.2017.02.033
   Habib A, 2019, GUT, V68, P522, DOI 10.1136/gutjnl-2018-316137
   Harasim-Symbor E, 2020, MOLECULES, V25, DOI 10.3390/molecules25081932
   Harasim-Symbor E, 2019, CHEM PHYS LIPIDS, V218, P141, DOI 10.1016/j.chemphyslip.2018.12.007
   Ho WSV, 2017, ADV PHARMACOL, V80, P329, DOI 10.1016/bs.apha.2017.05.002
   Horckmans M, 2018, CIRCULATION, V137, P948, DOI 10.1161/CIRCULATIONAHA.117.028833
   Howlett AC, 2002, PROSTAG OTH LIPID M, V68-9, P619, DOI 10.1016/S0090-6980(02)00060-6
   Huggins JP, 2012, PAIN, V153, P1837, DOI 10.1016/j.pain.2012.04.020
   Jones D, 2008, NAT REV DRUG DISCOV, V7, P961, DOI 10.1038/nrd2775
   Joshi N, 2019, ADV EXP MED BIOL, V1162, P1, DOI 10.1007/978-3-030-21737-2_1
   Jourdan T, 2017, MOL METAB, V6, P1517, DOI 10.1016/j.molmet.2017.08.011
   Kerbrat A, 2016, NEW ENGL J MED, V375, P1717, DOI 10.1056/NEJMoa1604221
   Kitsis RN, 2006, NEW ENGL J MED, V355, P513, DOI 10.1056/NEJMcibr063197
   Klumpers LE, 2013, BRIT J CLIN PHARMACO, V76, P846, DOI 10.1111/bcp.12141
   Krenning G, 2010, J CELL PHYSIOL, V225, P631, DOI 10.1002/jcp.22322
   Lahesmaa M, 2018, DIABETES, V67, P1226, DOI 10.2337/db17-1366
   Lau BK, 2017, NEUROPHARMACOLOGY, V124, P38, DOI 10.1016/j.neuropharm.2017.05.033
   Le Foll B, 2009, PSYCHOPHARMACOLOGY, V205, P171, DOI 10.1007/s00213-009-1506-7
   Lee WS, 2016, MOL MED, V22, P136, DOI 10.2119/molmed.2016.00007
   Li X, 2016, CELL PHYSIOL BIOCHEM, V39, P1521, DOI 10.1159/000447855
   Liu J, 2019, HEPATOLOGY, V69, P1535, DOI 10.1002/hep.30364
   Logue SE, 2005, J MOL CELL CARDIOL, V38, P21, DOI 10.1016/j.yjmcc.2004.11.009
   Giménez VMM, 2018, THER ADV CARDIO DIS, V12, P177, DOI 10.1177/1753944718773690
   MATSUDA LA, 1990, NATURE, V346, P561, DOI 10.1038/346561a0
   Matyas C, 2020, HEPATOLOGY, V71, P1391, DOI 10.1002/hep.30916
   MECHOULAM R, 1967, TETRAHEDRON LETT, P1109
   MECHOULAM R, 1963, TETRAHEDRON, V19, P2073, DOI 10.1016/0040-4020(63)85022-X
   Micale V, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.00207
   Miranda K, 2019, FRONT IMMUNOL, V10, P1, DOI 10.3389/fimmu.2019.01049
   Molica F, 2013, J LIPID RES, V54, P1360, DOI 10.1194/jlr.M035147
   Morales P, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00422
   Nagappan A, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20092109
   Nava-Molina L, 2020, NUTR DIABETES, V10, DOI 10.1038/s41387-020-0110-0
   Nikolic D, 2017, CURR PHARM DESIGN, V23, P894, DOI 10.2174/1381612822666161006151134
   Omura S, 2005, GENES CELLS, V10, P277, DOI 10.1111/j.1365-2443.2005.00832.x
   Pacher P, 2018, NAT REV CARDIOL, V15, P151, DOI 10.1038/nrcardio.2017.130
   Page RL, 2020, CIRCULATION, V142, pE131, DOI 10.1161/CIR.0000000000000883
   Palomares B, 2020, BIOCHEM PHARMACOL, V171, DOI 10.1016/j.bcp.2019.113693
   Palomares B, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-34259-0
   Patel S, 2003, BRIT J PHARMACOL, V139, P1005, DOI 10.1038/sj.bjp.0705334
   Pedzinska-Betiuk A, 2017, BRIT J PHARMACOL, V174, P2114, DOI 10.1111/bph.13830
   Pei SJ, 2018, BIOCHEM BIOPH RES CO, V503, P744, DOI 10.1016/j.bbrc.2018.06.070
   Piscitelli F, 2019, CURR PHARM DESIGN, V25, P3147, DOI 10.2174/1381612825666190826162735
   Postnov A, 2018, CTS-CLIN TRANSL SCI, V11, P397, DOI 10.1111/cts.12548
   Puhl SL, 2020, BBA-MOL CELL RES, V1867, DOI 10.1016/j.bbamcr.2019.03.009
   Rajesh M, 2012, DIABETES, V61, P716, DOI 10.2337/db11-0477
   Rajesh M, 2010, J AM COLL CARDIOL, V56, P2115, DOI 10.1016/j.jacc.2010.07.033
   Rajesh M, 2008, BIOCHEM BIOPH RES CO, V377, P1248, DOI 10.1016/j.bbrc.2008.10.159
   Remiszewski P, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21041295
   Rezkalla S, 2019, TRENDS CARDIOVAS MED, V29, P403, DOI 10.1016/j.tcm.2018.11.004
   Richards JR, 2020, CLIN TOXICOL, V58, P861, DOI 10.1080/15563650.2020.1743847
   RINALDICARMONA M, 1994, FEBS LETT, V350, P240, DOI 10.1016/0014-5793(94)00773-X
   Rossi F, 2016, J CLIN ENDOCR METAB, V101, P3469, DOI 10.1210/jc.2015-4381
   Rossi F, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19092690
   Russo EB, 2017, ADV PHARMACOL, V80, P67, DOI 10.1016/bs.apha.2017.03.004
   Schloss MJ, 2019, CARDIOVASC RES, V115, P602, DOI 10.1093/cvr/cvy242
   Schwartz Margit, 2018, Oncotarget, V9, P34595, DOI 10.18632/oncotarget.26191
   Shrestha N, 2018, DRUG DISCOV TODAY, V23, P592, DOI 10.1016/j.drudis.2018.01.029
   Simon V, 2017, EUR J ENDOCRINOL, V176, pR309, DOI 10.1530/EJE-16-1044
   Singh A, 2018, CARDIOL THER, V7, P45, DOI 10.1007/s40119-017-0102-x
   Stasiulewicz A, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21082778
   Steffens S, 2012, BRIT J PHARMACOL, V167, P313, DOI 10.1111/j.1476-5381.2012.02042.x
   Stella N, 1997, NATURE, V388, P773, DOI 10.1038/42015
   Sugamura K, 2009, CIRCULATION, V119, P28, DOI 10.1161/CIRCULATIONAHA.108.811992
   Sun HJ, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/2186383
   Takano A, 2014, SYNAPSE, V68, P89, DOI 10.1002/syn.21721
   Tam J, 2012, CELL METAB, V16, P167, DOI 10.1016/j.cmet.2012.07.002
   Toczek M, 2018, LIFE SCI, V204, P20, DOI 10.1016/j.lfs.2018.04.054
   Travers JG, 2016, CIRC RES, V118, P1021, DOI 10.1161/CIRCRESAHA.115.306565
   Valenta I, 2018, JACC-CARDIOVASC IMAG, V11, P320, DOI 10.1016/j.jcmg.2017.11.019
   Walsh SK, 2010, BRIT J PHARMACOL, V160, P1234, DOI 10.1111/j.1476-5381.2010.00755.x
   Xu ZL, 2005, J CARDIOVASC PHARM, V46, P794, DOI 10.1097/01.fjc.0000188161.57018.29
   Yano Y, 2006, GENES CELLS, V11, P791, DOI 10.1111/j.1365-2443.2006.00979.x
   Youssef DA, 2019, CHEM-BIOL INTERACT, V297, P16, DOI 10.1016/j.cbi.2018.10.010
NR 98
TC 8
Z9 9
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD OCT 21
PY 2020
VL 22
IS 12
AR 98
DI 10.1007/s11906-020-01112-7
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA OL1JZ
UT WOS:000585099200001
PM 33089434
DA 2025-06-11
ER

PT J
AU Leonardi, BF
   Gosmann, G
   Zimmer, AR
AF Leonardi, Bianca F.
   Gosmann, Grace
   Zimmer, Aline R.
TI Modeling Diet-Induced Metabolic Syndrome in Rodents
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Review
DE C57BL; 6 mice; hypercaloric diets; metabolic syndrome; obesity; rodent
   models
ID HIGH-FAT-DIET; INDUCED INSULIN-RESISTANCE; HEPATIC LIPID-ACCUMULATION;
   ADIPOSE-TISSUE INFLAMMATION; INDUCED KIDNEY INJURY; INDUCED OBESITY;
   LIVER-DISEASE; OXIDATIVE STRESS; C57BL/6 MICE; ETHANOL EXTRACT
AB Standardized animal models represent one of the most valuable tools available to understand the mechanism underlying the metabolic syndrome (MetS) and to seek for new therapeutic strategies. However, there is considerable variability in the studies conducted with this essential purpose. This review presents an updated discussion of the most recent studies using diverse experimental conditions to induce MetS in rodents with unbalanced diets, discusses the key findings in metabolic outcomes, and critically evaluates what we have been learned from them and how to advance in the field. The study includes scientific reports sourced from the Web of Science and PubMed databases, published between January 2013 and June 2020, which used hypercaloric diets to induce metabolic disorders, and address the impact of the diet on metabolic parameters. The collected data are used as support to discuss variables such as sex, species, and age of the animals, the most favorable type of diet, and the ideal diet length to generate metabolic changes. The experimental characteristics propose herein improve the performance of a preclinical model that resembles the human MetS and will guide researchers to investigate new therapeutic alternatives with confidence and higher translational validity.
C1 [Leonardi, Bianca F.; Gosmann, Grace; Zimmer, Aline R.] Fed Univ Rio Grande do Sul UFRGS, Fac Pharm, Phytochem & Organ Synth Lab, Pharmaceut Sci Grad Program, 2752 Ipiranga Ave, BR-90610000 Porto Alegre, RS, Brazil.
C3 Universidade Federal do Rio Grande do Sul
RP Zimmer, AR (corresponding author), Fed Univ Rio Grande do Sul UFRGS, Fac Pharm, Phytochem & Organ Synth Lab, Pharmaceut Sci Grad Program, 2752 Ipiranga Ave, BR-90610000 Porto Alegre, RS, Brazil.
EM aline.zimmer@ufrgs.br
RI Zimmer, Aline/A-3330-2016; Leonardi, Bianca/KIJ-7747-2024; Gosmann,
   Grace/AAJ-9760-2020; Gosmann, Grace/G-3331-2012
OI Franco Leonardi, Bianca/0000-0002-9777-9975; Gosmann,
   Grace/0000-0001-6823-8312
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq;
   Fundacao de Amparo a Pesquisa do Rio Grande do Sul-FAPERGS; Coordenacao
   de Aperfeicoamento de Pessoal de Nivel Superior-CAPES; Graduate Program
   of Pharmaceutical Sciences-PPGCF/UFRGS
FX This work was supported by Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico-CNPq; Fundacao de Amparo a Pesquisa do Rio
   Grande do Sul-FAPERGS; Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior-CAPES; and Graduate Program of Pharmaceutical
   Sciences-PPGCF/UFRGS.
CR Aboonabi A, 2019, J HUM HYPERTENS, V33, P844, DOI 10.1038/s41371-019-0273-0
   Adeshirlarijaney A, 2019, AM J PHYSIOL-ENDOC M, V317, pE1121, DOI 10.1152/ajpendo.00245.2019
   Ahn J, 2013, FOOD CHEM TOXICOL, V51, P439, DOI 10.1016/j.fct.2012.08.048
   Albouery M, 2020, EXP EYE RES, V196, DOI 10.1016/j.exer.2020.108059
   Alcala M., 2017, SCI REP, V7, P12
   Alcala M, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0186579
   Allard JS, 2016, BEHAV BRAIN RES, V301, P1, DOI 10.1016/j.bbr.2015.12.012
   Almeda-Valdés P, 2009, ANN HEPATOL, V8, pS18, DOI 10.1016/S1665-2681(19)31822-8
   Almeida-Suhett Camila P, 2019, Nutr Neurosci, V22, P19, DOI 10.1080/1028415X.2017.1349359
   Alqahtani S, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.00818
   Anil TM, 2014, BMC PHARMACOL TOXICO, V15, DOI 10.1186/2050-6511-15-43
   [Anonymous], 2010, Nat Methods, V7, P413
   Ansari A, 2016, MOLECULES, V21, DOI 10.3390/molecules21111522
   Aoqui C, 2014, CARDIOVASC DIABETOL, V13, DOI 10.1186/1475-2840-13-31
   Asha GV, 2016, ARCH PHYSIOL BIOCHEM, V122, P19, DOI 10.3109/13813455.2015.1126609
   Atorrasagasti C, 2019, CLIN SCI, V133, P351, DOI 10.1042/CS20180714
   Ayabe T, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-23213-9
   Bading-Taika Bayissi, 2018, J Food Bioact, V3, P111, DOI 10.31665/JFB.2018.3154
   Bae UJ, 2017, J FUNCT FOODS, V31, P208, DOI 10.1016/j.jff.2017.02.008
   Barbosa-da-Silva S, 2014, HEPATOL RES, V44, P450, DOI 10.1111/hepr.12138
   Barr LA, 2015, NITRIC OXIDE-BIOL CH, V46, P145, DOI 10.1016/j.niox.2014.12.013
   Bruce-Keller AJ, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-58005-7
   Buettner R, 2007, OBESITY, V15, P798, DOI 10.1038/oby.2007.608
   Calligaris SD, 2013, BIOL RES, V46, P251, DOI 10.4067/S0716-97602013000300005
   Calligaris SD, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0060931
   Cao K, 2014, FREE RADICAL BIO MED, V67, P396, DOI 10.1016/j.freeradbiomed.2013.11.029
   Casellas J, 2011, ANIMAL, V5, P1, DOI 10.1017/S1751731110001667
   Centrone M, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9030268
   Cesaretti Mario Luís Ribeiro, 2006, Arq Bras Endocrinol Metab, V50, P190, DOI 10.1590/S0004-27302006000200005
   Chan SMH, 2015, BBA-MOL BASIS DIS, V1852, P1511, DOI 10.1016/j.bbadis.2015.04.005
   Chang CJ, 2018, INT J OBESITY, V42, P231, DOI 10.1038/ijo.2017.149
   Chappuis E, 2017, MOLECULES, V22, DOI 10.3390/molecules22101725
   Che Y, 2018, MOL MED REP, V18, P3251, DOI 10.3892/mmr.2018.9301
   Chen CM, 2015, EUR J PHARMACOL, V761, P298, DOI 10.1016/j.ejphar.2015.06.021
   Chen CC, 2016, INT J MOL MED, V37, P743, DOI 10.3892/ijmm.2016.2475
   Chen GJ, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700485
   Chen GJ, 2018, J AGR FOOD CHEM, V66, P2783, DOI 10.1021/acs.jafc.8b00296
   Chen HJ, 2018, BIOMED PHARMACOTHER, V97, P1386, DOI 10.1016/j.biopha.2017.09.093
   Chen K, 2019, FOOD FUNCT, V10, P814, DOI [10.1039/c8fo01236a, 10.1039/C8FO01236A]
   Chen VP, 2017, P NATL ACAD SCI USA, V114, P10960, DOI 10.1073/pnas.1706517114
   Chen WH, 2019, BIOCHEM BIOPH RES CO, V509, P40, DOI 10.1016/j.bbrc.2018.12.003
   Chen YN, 2019, BIOMED PHARMACOTHER, V115, DOI 10.1016/j.biopha.2019.108868
   Cho J, 2015, MED SCI SPORT EXER, V47, P1624, DOI 10.1249/MSS.0000000000000595
   Choi HK, 2017, J MED FOOD, V20, P251, DOI 10.1089/jmf.2016.3877
   Choi JS, 2013, J NUTR BIOCHEM, V24, P1634, DOI 10.1016/j.jnutbio.2013.02.004
   Choi JH, 2016, J CLIN BIOCHEM NUTR, V59, P31, DOI 10.3164/jcbn.15-30
   Choi WH, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201700218
   Clayton JA, 2014, NATURE, V509, P282, DOI 10.1038/509282a
   Collins S, 2004, PHYSIOL BEHAV, V81, P243, DOI 10.1016/j.physbeh.2004.02.006
   Cremonini E, 2016, ARCH BIOCHEM BIOPHYS, V599, P13, DOI 10.1016/j.abb.2016.03.006
   Cui LJ, 2016, BIOMED PHARMACOTHER, V81, P111, DOI 10.1016/j.biopha.2016.03.038
   Filomeno CED, 2020, EXP PARASITOL, V212, DOI 10.1016/j.exppara.2020.107889
   Damgaard MTF, 2018, J NUTR BIOCHEM, V54, P66, DOI 10.1016/j.jnutbio.2017.09.026
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Diez-Echave P, 2020, MOL NUTR FOOD RES, V64, DOI 10.1002/mnfr.202000005
   Diez-Echave P, 2020, FOOD RES INT, V127, DOI 10.1016/j.foodres.2019.108722
   Ding LL, 2014, J PHARMACOL EXP THER, V351, P474, DOI 10.1124/jpet.114.217968
   Dissard R, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076703
   Dobner J, 2017, J NUTR BIOCHEM, V49, P22, DOI 10.1016/j.jnutbio.2017.07.009
   Doerner SK, 2016, MOL CANCER RES, V14, P953, DOI 10.1158/1541-7786.MCR-16-0153
   Drechsler S, 2016, MECH AGEING DEV, V160, P54, DOI 10.1016/j.mad.2016.07.005
   Elaine W, 2018, PHYTOMEDICINE, V42, P112, DOI 10.1016/j.phymed.2018.03.028
   Ellenbroek B, 2016, DIS MODEL MECH, V9, P1079, DOI 10.1242/dmm.026120
   Eskens BJM, 2014, PHYSIOL REP, V2, DOI 10.1002/phy2.194
   Fan MQ, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112586
   Fan SJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051007
   Fang J, 2017, BIOMED REP, V7, P337, DOI 10.3892/br.2017.972
   Fellmann L, 2013, PHARMACOL THERAPEUT, V137, P331, DOI 10.1016/j.pharmthera.2012.11.004
   Ferreira PS, 2016, FOOD FUNCT, V7, P2675, DOI [10.1039/C5FO01541C, 10.1039/c5fo01541c]
   Figarola JL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0083801
   Fischer IP, 2018, INT J OBESITY, V42, P507, DOI 10.1038/ijo.2017.224
   Fontaine DA, 2016, DIABETES, V65, P25, DOI 10.2337/db15-0982
   Fontana L, 2013, HEPATOLOGY, V57, P995, DOI 10.1002/hep.26099
   Freire-Regatillo A, 2020, J NEUROENDOCRINOL, V32, DOI 10.1111/jne.12756
   Fukuda-Tsuru S, 2014, EUR J PHARMACOL, V723, P207, DOI 10.1016/j.ejphar.2013.11.030
   Fukui A, 2017, J CARDIOVASC ELECTR, V28, P702, DOI 10.1111/jce.13200
   Galea LAM, 2020, FRONT NEUROENDOCRIN, V56, DOI 10.1016/j.yfrne.2019.100817
   Gamliel-Lazarovich A, 2013, EUR J GASTROEN HEPAT, V25, P1086, DOI 10.1097/MEG.0b013e328360554a
   Gao LH, 2014, J ETHNOPHARMACOL, V151, P675, DOI 10.1016/j.jep.2013.11.024
   Gao XY, 2018, INFECT IMMUN, V86, DOI 10.1128/IAI.00601-17
   Ghadieh HE, 2015, NUTR METAB, V12, DOI 10.1186/s12986-015-0014-5
   Ghosh S, 2019, BIOL SEX DIFFER, V10, DOI 10.1186/s13293-019-0233-y
   Gil-Ortega M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0095312
   Glastras SJ, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0162131
   Goldsworthy ME, 2014, MAMM GENOME, V25, P487, DOI 10.1007/s00335-014-9539-6
   Gong F, 2019, BIOCHEM BIOPH RES CO, V514, P593, DOI 10.1016/j.bbrc.2019.04.069
   Gong F, 2018, BIOCHEM BIOPH RES CO, V504, P797, DOI 10.1016/j.bbrc.2018.08.059
   Goossens GH, 2008, PHYSIOL BEHAV, V94, P206, DOI 10.1016/j.physbeh.2007.10.010
   Gotoh K, 2013, OBES RES CLIN PRACT, V7, pE342, DOI 10.1016/j.orcp.2013.04.001
   Griffin LE, 2017, FOOD FUNCT, V8, P3510, DOI [10.1039/c7fo01236e, 10.1039/C7FO01236E]
   Grundy SM, 2007, J CLIN ENDOCR METAB, V92, P399, DOI 10.1210/jc.2006-0513
   Grundy SM, 2004, J CLIN ENDOCR METAB, V89, P2595, DOI 10.1210/jc.2004-0372
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Gu YY, 2014, J NUTR BIOCHEM, V25, P439, DOI 10.1016/j.jnutbio.2013.12.004
   Guo J, 2018, FRONT GENET, V9, DOI [10.3389/fgene.2018.00012, 10.3389/fgene.2018.00122]
   Gupta D, 2012, CURR DIABETES REV, V8, P76, DOI 10.2174/157339912799424564
   Ha BG, 2013, MAR DRUGS, V11, P4193, DOI 10.3390/md11114193
   Haley MJ, 2019, J CEREBR BLOOD F MET, V39, P1026, DOI 10.1177/0271678X17744718
   Hammad SS, 2017, LIPIDS, V52, P803, DOI 10.1007/s11745-017-4291-9
   Hariri N, 2010, NUTR RES REV, V23, P270, DOI 10.1017/S0954422410000168
   He C, 2018, CLIN RES HEPATOL GAS, V42, P360, DOI 10.1016/j.clinre.2017.12.008
   Heinonen I, 2014, ACTA PHYSIOL, V211, P515, DOI 10.1111/apha.12253
   Herbert D, 2018, J INVEST DERMATOL, V138, P1999, DOI 10.1016/j.jid.2018.03.1522
   Van Herck MA, 2020, CELL MOL GASTROENTER, V10, P467, DOI [10.1016/J.JCMGH.2020.04.010, 10.1016/j.jcmgh.2020.04.010]
   Heyman L, 2014, J NUTR METAB, V2014, DOI 10.1155/2014/403041
   Higa Talita S, 2014, Int J Physiol Pathophysiol Pharmacol, V6, P47
   Hinder LM, 2017, DIS MODEL MECH, V10, P717, DOI 10.1242/dmm.028530
   Hong Y, 2020, J FOOD SCI, V85, P2216, DOI 10.1111/1750-3841.15166
   Höper AC, 2013, BRIT J NUTR, V110, P2186, DOI 10.1017/S0007114513001839
   Hsieh CH, 2015, BMC GENOMICS, V16, DOI 10.1186/s12864-015-1896-3
   Hu BF, 2020, PHARMACOL RES, V159, DOI 10.1016/j.phrs.2020.104942
   Hu G, 2004, ARCH INTERN MED, V164, P1066, DOI 10.1001/archinte.164.10.1066
   Huang JW, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20174223
   Huang JP, 2018, J CARDIOVASC PHARM, V72, P231, DOI 10.1097/FJC.0000000000000621
   Huh JY, 2017, BIOCHEM BIOPH RES CO, V491, P890, DOI 10.1016/j.bbrc.2017.07.132
   Hul M. V., 2018, AM J PHYSIOL-ENDOC M, V314, pE334
   Hull RL, 2017, J ENDOCRINOL, V233, P53, DOI 10.1530/JOE-16-0377
   Iannaccone PM, 2009, DIS MODEL MECH, V2, P206, DOI 10.1242/dmm.002733
   Ikuta T, 2015, BIOSCI BIOTECH BIOCH, V79, P2044, DOI 10.1080/09168451.2015.1056510
   Im AR, 2018, NUTRIENTS, V10, DOI 10.3390/nu10060735
   International Diabetes Federation, 2006, IDF CONS WORLDW DEF
   Jackson RM, 2019, OBESITY, V27, P2025, DOI 10.1002/oby.22652
   Jackson SJ, 2017, LAB ANIM-UK, V51, P160, DOI 10.1177/0023677216653984
   Jang A, 2014, FOOD FUNCT, V5, P1966, DOI [10.1039/c4fo00246f, 10.1039/C4FO00246F]
   Jang HJ, 2013, AM J PHYSIOL-ENDOC M, V305, pE1444, DOI 10.1152/ajpendo.00434.2013
   Jang JW, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/5614091
   Janovská P, 2013, PHYSIOL RES, V62, P153, DOI 10.33549/physiolres.932464
   Jo MG, 2019, INT J OBESITY, V43, P2422, DOI 10.1038/s41366-019-0383-3
   Jones NS, 2019, ENEURO, V6, DOI 10.1523/ENEURO.0267-19.2019
   Jung DY, 2017, BIOCHEM BIOPH RES CO, V494, P587, DOI 10.1016/j.bbrc.2017.10.120
   Kandhare AD, 2018, RSC ADV, V8, P32401, DOI 10.1039/c8ra05204b
   Kang JH, 2017, NUTR RES PRACT, V11, P17, DOI 10.4162/nrp.2017.11.1.17
   Kar S, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8120638
   Karunakaran S, 2018, PHYSIOL GENOMICS, V50, P35, DOI 10.1152/physiolgenomics.00059.2017
   Kelley EE, 2014, CARDIOVASC RES, V101, P352, DOI 10.1093/cvr/cvt341
   Kim GH, 2019, NUTRIENTS, V11, DOI 10.3390/nu11051162
   Kim HJ, 2018, NUTR RES PRACT, V12, P503, DOI 10.4162/nrp.2018.12.6.503
   Kim HM, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0179204
   Kim J, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18040846
   Kim MJ, 2014, PHYTOTHER RES, V28, P137, DOI 10.1002/ptr.4965
   Kim SH, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700701
   Kim SH, 2016, J ETHNOPHARMACOL, V192, P201, DOI 10.1016/j.jep.2016.07.023
   Kim SW, 2013, BIOCHEM BIOPH RES CO, V431, P258, DOI 10.1016/j.bbrc.2012.12.121
   Kim SH, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/921012
   Kleinert M, 2018, NAT REV ENDOCRINOL, V14, P140, DOI 10.1038/nrendo.2017.161
   Kopec AK, 2017, J CLIN INVEST, V127, P3152, DOI [10.1172/JCI92744, 10.1172/jci92744]
   Kopec AK, 2014, J PHARMACOL EXP THER, V351, P288, DOI 10.1124/jpet.114.218545
   Kulkarni NM, 2015, PHARM BIOL, V53, P1110, DOI 10.3109/13880209.2014.960944
   Kwon MJ, 2019, PHARMACOGN MAG, V15, P363, DOI 10.4103/pm.pm_376_18
   Kwon M, 2018, J FUNCT FOODS, V47, P288, DOI 10.1016/j.jff.2018.05.063
   Larsen JR, 2018, EXPERT REV CLIN PHAR, V11, P397, DOI 10.1080/17512433.2018.1429910
   Le JM, 2019, ACTA PHARM SIN B, V9, P758, DOI 10.1016/j.apsb.2019.01.014
   Lee CW, 2017, TRANSL RES, V182, P61, DOI 10.1016/j.trsl.2016.11.003
   Lee ES, 2020, METABOLISM, V103, DOI 10.1016/j.metabol.2019.154015
   Lee J, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201800329
   Lee JH, 2018, CHEM-BIOL INTERACT, V289, P68, DOI 10.1016/j.cbi.2018.04.023
   Lee MR, 2019, PHYTOMEDICINE, V55, P14, DOI 10.1016/j.phymed.2018.07.008
   Lee S., 2015, BRIC VIEW, V2015, pT09
   Lee S. B., 2019, AM J PHYSIOL-GASTR L, V317, pC449
   Lee SE, 2013, BIOSCI BIOTECH BIOCH, V77, P544, DOI 10.1271/bbb.120667
   Lee SW, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/9058956
   Lee SK, 2018, BMB REP, V51, P167, DOI 10.5483/BMBRep.2018.51.4.034
   Lee YJ, 2015, FOOD SCI BIOTECHNOL, V24, P2235, DOI 10.1007/s10068-015-0298-2
   Lee YS, 2018, NUTRIENTS, V10, DOI 10.3390/nu10091204
   Lee YS, 2018, NUTRIENTS, V10, DOI 10.3390/nu10081087
   Lee Y, 2017, BIOSCI BIOTECH BIOCH, V81, P595, DOI 10.1080/09168451.2016.1258986
   Li CX, 2015, AM J PHYSIOL-ENDOC M, V309, pE802, DOI 10.1152/ajpendo.00158.2015
   Li C, 2018, BIOCHEM BIOPH RES CO, V507, P22, DOI 10.1016/j.bbrc.2018.10.132
   Li F, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01366
   Li J, 2018, MOL MED REP, V17, P4823, DOI 10.3892/mmr.2018.8440
   Li RS, 2016, DNA CELL BIOL, V35, P51, DOI 10.1089/dna.2015.2932
   Li XX, 2014, J MED FOOD, V17, P1287, DOI 10.1089/jmf.2014.0016
   Liao MJ, 2018, BIOCHEM BIOPH RES CO, V499, P743, DOI 10.1016/j.bbrc.2018.03.182
   Lim DW, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-45099-x
   Lim SM, 2017, NUTR RES, V41, P86, DOI 10.1016/j.nutres.2017.04.003
   Lin HL, 2020, J FOOD BIOCHEM, V44, DOI 10.1111/jfbc.13129
   Liou CJ, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8050447
   Liu CY, 2016, INT J GERONTOL, V10, P105, DOI 10.1016/j.ijge.2015.10.004
   Liu M, 2015, SCI REP-UK, V5, DOI 10.1038/srep07973
   Liu R, 2020, J NUTR BIOCHEM, V79, DOI 10.1016/j.jnutbio.2019.108330
   Liu TJ, 2020, NUTRIENTS, V12, DOI 10.3390/nu12040977
   Liu Y, 2019, AM J PHYSIOL-ENDOC M, V316, pE260, DOI 10.1152/ajpendo.00387.2018
   Lizarbe B, 2019, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00985
   Bargut TCL, 2014, LIPIDS, V49, P431, DOI 10.1007/s11745-014-3892-9
   Lu YL, 2019, FOOD FUNCT, V10, P4153, DOI 10.1039/c8fo02379d
   Justo ML, 2016, EUR J NUTR, V55, P2011, DOI 10.1007/s00394-015-1015-x
   Ma YJ, 2015, PHARM RES-DORDR, V32, P1200, DOI 10.1007/s11095-014-1526-9
   Ma YL, 2018, BIOCHEM BIOPH RES CO, V503, P1651, DOI 10.1016/j.bbrc.2018.07.095
   Magge SN, 2017, PEDIATRICS, V140, DOI 10.1542/peds.2017-1603
   Mancuso P, 2019, FRONT ENDOCRINOL, V10, DOI [10.3389/fendo.2019.00137, 10.3389/fendo.019.00137]
   Marin V, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0158817
   Marques C, 2016, ADIPOCYTE, V5, P11, DOI 10.1080/21623945.2015.1061723
   Mells JE, 2015, J NUTR BIOCHEM, V26, P285, DOI 10.1016/j.jnutbio.2014.11.002
   Mendrick DL, 2018, TOXICOL SCI, V162, P36, DOI 10.1093/toxsci/kfx233
   Micheli L, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081778
   Min B, 2014, NUTR RES PRACT, V8, P655, DOI 10.4162/nrp.2014.8.6.655
   Moon YJ, 2014, NUTRIENTS, V6, P1016, DOI 10.3390/nu6031016
   Morrison KE, 2020, MICROBIOME, V8, DOI 10.1186/s40168-020-0791-6
   Mouhid L, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010072
   Mubarak A, 2013, J AGR FOOD CHEM, V61, P4371, DOI 10.1021/jf400920x
   Murakami S, 2018, AMINO ACIDS, V50, P1279, DOI 10.1007/s00726-018-2605-8
   Murakami Y, 2016, J FOOD SCI, V81, pH216, DOI 10.1111/1750-3841.13166
   Musovic S, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-47113-8
   Na HY, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20030727
   Na HY, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/4658543
   Nag S, 2019, MOL CELL BIOCHEM, V461, P195, DOI 10.1007/s11010-019-03602-y
   Namen M. V., 2019, METAB CLIN EXP, V101
   Nilsson C, 2012, ACTA PHARMACOL SIN, V33, P173, DOI 10.1038/aps.2011.203
   NUNESSOUZA V, 2016, OXID MED CELL LONGEV, V2016, DOI DOI 10.1155/2016/1987960
   Nyavor Y, 2019, CELL TISSUE RES, V376, P325, DOI 10.1007/s00441-019-03002-0
   O'Brien PD, 2020, DIS MODEL MECH, V13, DOI 10.1242/dmm.042101
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Oh HS, 2019, J SCI FOOD AGR, V99, P2602, DOI 10.1002/jsfa.9478
   Oh YJ, 2019, J MED FOOD, V22, P1199, DOI 10.1089/jmf.2018.4349
   Oliveira LSC, 2014, J NUTR BIOCHEM, V25, P193, DOI 10.1016/j.jnutbio.2013.10.006
   Omar B, 2012, NUTRIENTS, V4, P1367, DOI 10.3390/nu4101367
   Otranto M, 2013, WOUND REPAIR REGEN, V21, P464, DOI 10.1111/wrr.12042
   Paiva AA, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/1838679
   Panchal SK, 2011, J BIOMED BIOTECHNOL, DOI 10.1155/2011/351982
   Parilla JH, 2018, J HISTOCHEM CYTOCHEM, V66, P523, DOI 10.1369/0022155418765164
   Park SB, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061319
   Paruthiyil S, 2018, BIOL SEX DIFFER, V9, DOI 10.1186/s13293-018-0208-4
   Patel VS, 2017, OBESITY, V25, P1745, DOI 10.1002/oby.21958
   Pellizzon MA, 2018, NUTR METAB, V15, DOI 10.1186/s12986-018-0243-5
   Pepping JK, 2013, AM J PHYSIOL-ENDOC M, V304, pE392, DOI 10.1152/ajpendo.00398.2012
   Pérez MM, 2019, IMMUNOLOGY, V156, P339, DOI 10.1111/imm.13028
   Pi-Sunyer FX, 2002, OBES RES, V10, p97S, DOI 10.1038/oby.2002.202
   Piao L, 2016, BRIT J PHARMACOL, V173, P2622, DOI 10.1111/bph.13541
   Pires KM, 2014, OBESITY, V22, P178, DOI 10.1002/oby.20465
   Porras D, 2017, FREE RADICAL BIO MED, V102, P188, DOI 10.1016/j.freeradbiomed.2016.11.037
   Qiao JT, 2018, METABOLISM, V81, P13, DOI 10.1016/j.metabol.2017.09.010
   Ramdhave AS, 2017, AM J TRANSL RES, V9, P830
   Reis FCG, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0134844
   Ribeiro R. S., 2017, PLOS ONE, V12, P17
   Rodríguez-Correa E, 2020, NUTR DIABETES, V10, DOI 10.1038/s41387-020-0127-4
   Rodríguez-Rodríguez C, 2015, FOOD FUNCT, V6, P805, DOI [10.1039/c4fo01092b, 10.1039/C4FO01092B]
   Roh JS, 2017, J ETHNOPHARMACOL, V206, P315, DOI 10.1016/j.jep.2017.06.008
   Roopchand DE, 2015, DIABETES, V64, P2847, DOI 10.2337/db14-1916
   Sá GD, 2017, LIFE SCI, V189, P8, DOI 10.1016/j.lfs.2017.09.012
   Sabater AG, 2017, CELL PHYSIOL BIOCHEM, V42, P564, DOI 10.1159/000477606
   Sadasivan SK, 2014, EUR J PHARMACOL, V729, P94, DOI 10.1016/j.ejphar.2014.01.073
   Sadasivuni MK, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-83
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Salinero AE, 2018, INT J OBESITY, V42, P1088, DOI 10.1038/s41366-018-0023-3
   Sampath C, 2017, FOOD CHEM, V226, P79, DOI 10.1016/j.foodchem.2017.01.056
   Sampath C, 2017, BIOMED PHARMACOTHER, V87, P73, DOI 10.1016/j.biopha.2016.12.082
   Schipke J, 2019, J NUTR, V149, P451, DOI 10.1093/jn/nxy272
   Schofield S, 2017, INT J OBESITY, V41, P402, DOI 10.1038/ijo.2016.193
   Schultz A, 2015, FOOD FUNCT, V6, P1684, DOI [10.1039/C5FO00251F, 10.1039/c5fo00251f]
   Schultz A, 2013, INT J MOL SCI, V14, P21873, DOI 10.3390/ijms141121873
   Schuster F, 2018, PFLUG ARCH EUR J PHY, V470, P1673, DOI 10.1007/s00424-018-2178-0
   Shang QS, 2017, J FUNCT FOODS, V28, P138, DOI 10.1016/j.jff.2016.11.002
   Shansky RM, 2019, SCIENCE, V364, P825, DOI 10.1126/science.aaw7570
   Shimizu K, 2019, BIOL PHARM BULL, V42, P1295, DOI 10.1248/bpb.b18-00984
   Shin SH, 2013, INT J PHARMACOL, V9, P143, DOI 10.3923/ijp.2013.143.149
   Sid V, 2015, AM J PHYSIOL-REG I, V309, pR1215, DOI 10.1152/ajpregu.00260.2015
   Silvester AJ, 2018, J NUTR BIOCHEM, V61, P56, DOI 10.1016/j.jnutbio.2018.07.004
   Simon MM, 2013, GENOME BIOL, V14, DOI 10.1186/gb-2013-14-7-r82
   Singh VP, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0129850
   Skaznik-Wikiel ME, 2016, BIOL REPROD, V94, DOI 10.1095/biolreprod.115.137414
   Soares AG, 2017, BIOMED RES INT, V2017, DOI 10.1155/2017/5038602
   Softic S, 2017, J CLIN INVEST, V127, P4059, DOI 10.1172/JCI94585
   Sohn M, 2017, AM J PHYSIOL-RENAL, V312, pF323, DOI 10.1152/ajprenal.00596.2015
   Solini A, 2013, J PATHOL, V231, P342, DOI 10.1002/path.4237
   Son Y, 2014, J MED FOOD, V17, P1322, DOI 10.1089/jmf.2014.3194
   Song HZ, 2016, NUTR RES, V36, P710, DOI 10.1016/j.nutres.2016.01.011
   Song HZ, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0149670
   Song HZ, 2016, J AGR FOOD CHEM, V64, P236, DOI 10.1021/acs.jafc.5b05177
   Song K, 2020, LIFE SCI, V252, DOI 10.1016/j.lfs.2020.117633
   Soni NK, 2015, LIPIDS HEALTH DIS, V14, DOI 10.1186/s12944-015-0072-8
   Spruiell K, 2014, J BIOL CHEM, V289, P3244, DOI 10.1074/jbc.M113.494575
   Su HM, 2016, J ZHEJIANG UNIV-SC B, V17, P437, DOI 10.1631/jzus.B1600074
   Sun J, 2016, J FUNCT FOODS, V24, P482, DOI 10.1016/j.jff.2016.04.032
   Sun XW, 2020, J AGR FOOD CHEM, V68, P5118, DOI 10.1021/acs.jafc.0c01467
   Sung YY, 2014, J FUNCT FOODS, V6, P428, DOI 10.1016/j.jff.2013.11.009
   Sunil V, 2017, BIOMED PHARMACOTHER, V89, P880, DOI 10.1016/j.biopha.2017.01.182
   Takase K, 2016, OBESITY, V24, P886, DOI 10.1002/oby.21441
   Tan S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0093510
   Tao WJ, 2019, MAR DRUGS, V17, DOI 10.3390/md17110645
   Tessitore A, 2016, BMC CANCER, V16, DOI 10.1186/s12885-015-2007-1
   Tian J, 2020, J DENT RES, V99, P839, DOI 10.1177/0022034520911037
   Torre-Villalvazo I, 2018, AM J PHYSIOL-ENDOC M, V314, pE53, DOI 10.1152/ajpendo.00108.2017
   Tran HQ, 2020, CELL MOL GASTROENTER, V9, P313, DOI 10.1016/j.jcmgh.2019.09.009
   Trzepizur W, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0124637
   Tsai SF, 2018, BRAIN RES, V1700, P66, DOI 10.1016/j.brainres.2018.07.017
   Valcarcel-Ares MN, 2019, J GERONTOL A-BIOL, V74, P290, DOI 10.1093/gerona/gly127
   Valenzuela R, 2016, FOOD FUNCT, V7, P140, DOI [10.1039/c5fo01086a, 10.1039/C5FO01086A]
   van der Heijden RA, 2015, AGING-US, V7, P256, DOI 10.18632/aging.100738
   Vargas-Robles H, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/467471
   Vassallo P, 2016, PROG CARDIOVASC DIS, V59, P172, DOI 10.1016/j.pcad.2016.07.012
   Vercalsteren E, 2019, ADIPOCYTE, V8, P105, DOI 10.1080/21623945.2019.1590893
   Vezza T, 2019, PHARMACOL RES, V150, DOI 10.1016/j.phrs.2019.104487
   Vitaglione P, 2019, J NUTR SCI, V8, DOI 10.1017/jns.2019.10
   Wada T, 2017, J ENDOCRINOL, V235, P179, DOI 10.1530/JOE-17-0351
   Wahlang B, 2013, J NUTR BIOCHEM, V24, P1587, DOI 10.1016/j.jnutbio.2013.01.009
   Wang CY, 2012, METHODS MOL BIOL, V821, P421, DOI 10.1007/978-1-61779-430-8_27
   Wang CL, 2017, J FUNCT FOODS, V35, P185, DOI 10.1016/j.jff.2017.05.041
   Wang HS, 2018, FOOD FUNCT, V9, P3916, DOI 10.1039/c8fo00209f
   Wang J, 2020, EUR J NUTR, V59, P699, DOI 10.1007/s00394-019-01938-1
   Wang JJ, 2015, ISME J, V9, P1, DOI 10.1038/ismej.2014.99
   Wang WW, 2018, FOOD AGR IMMUNOL, V29, P1116, DOI 10.1080/09540105.2018.1516739
   Wang XL, 2020, CARBOHYD POLYM, V240, DOI 10.1016/j.carbpol.2020.116261
   Wang YY, 2020, PLANTS-BASEL, V9, DOI 10.3390/plants9030383
   Wang Y, 2019, AM J PHYSIOL-CELL PH, V316, pC223, DOI 10.1152/ajpcell.00242.2018
   Warden CH, 2008, CELL METAB, V7, P277, DOI 10.1016/j.cmet.2008.03.014
   Werner P, 2017, METABOLOMICS, V13, DOI 10.1007/s11306-017-1181-3
   Willard JR, 2017, DIABETOLOGIA, V60, P701, DOI 10.1007/s00125-016-4172-4
   Wong SK, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0123-9
   Wu YY, 2017, AM J PHYSIOL-ENDOC M, V312, pE58, DOI 10.1152/ajpendo.00128.2016
   Xie ZX, 2014, J FUNCT FOODS, V8, P76, DOI 10.1016/j.jff.2014.03.003
   Xiong M., 2020, J NUTR BIOCH, V77
   Xu J, 2018, J FUNCT FOODS, V42, P216, DOI 10.1016/j.jff.2018.01.002
   Xu J, 2014, J NUTR, V144, P475, DOI 10.3945/jn.113.187450
   Xu MX, 2017, INT J NANOMED, V12, P327, DOI 10.2147/IJN.S116010
   Xu MX, 2019, J FUNCT FOODS, V53, P7, DOI 10.1016/j.jff.2018.12.007
   Xu MX, 2019, FOOD FUNCT, V10, P1302, DOI 10.1039/c8fo01615a
   Xu N, 2018, J AGR FOOD CHEM, V66, P3823, DOI 10.1021/acs.jafc.8b00138
   Xu PF, 2017, BBA-GEN SUBJECTS, V1861, P2690, DOI 10.1016/j.bbagen.2017.07.013
   Xu YH, 2017, J NAT PROD, V80, P2319, DOI 10.1021/acs.jnatprod.7b00365
   Xue RQ, 2019, FREE RADICAL BIO MED, V134, P119, DOI 10.1016/j.freeradbiomed.2019.01.011
   Yan SL, 2014, J AGR FOOD CHEM, V62, P4625, DOI 10.1021/jf501165z
   Yanagisawa R, 2014, ENVIRON HEALTH PERSP, V122, P277, DOI 10.1289/ehp.1307421
   Yang C, 2020, FOOD RES INT, V131, DOI 10.1016/j.foodres.2020.108994
   Yang JW, 2016, FASEB J, V30, P324, DOI 10.1096/fj.15-273771
   Yang Q., 2017, INT J MOL SCI, V18, P14
   Yang WQ, 2017, FOOD FUNCT, V8, P1481, DOI [10.1039/c6fo01841f, 10.1039/C6FO01841F]
   Yimam M, 2017, J MED FOOD, V20, P1100, DOI 10.1089/jmf.2017.0002
   Yu JH, 2017, J AM COLL NUTR, V36, P347, DOI 10.1080/07315724.2017.1302366
   Yu X, 2017, J AGR FOOD CHEM, V65, P9635, DOI 10.1021/acs.jafc.7b03325
   Yuan HR, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0053887
   Zai WJ, 2019, ACS APPL MATER INTER, V11, P4842, DOI 10.1021/acsami.8b19717
   Zeng SL, 2020, SCI ADV, V6, DOI 10.1126/sciadv.aax6208
   Zhang XY, 2018, MOLECULES, V23, DOI 10.3390/molecules23102701
   Zhang YZ, 2020, NUTR METAB, V17, DOI 10.1186/s12986-020-0433-9
   Zhao L, 2019, NUTRIENTS, V11, DOI 10.3390/nu11123054
   Zhao MJ, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201801417
   Zhao YT, 2019, J NUTR, V149, P776, DOI 10.1093/jn/nxz017
   Zhao YT, 2015, J AGR FOOD CHEM, V63, P4843, DOI 10.1021/acs.jafc.5b01246
   Zheng JP, 2020, J ETHNOPHARMACOL, V246, DOI 10.1016/j.jep.2019.112225
   Zheng JP, 2019, J DIABETES, V11, P32, DOI 10.1111/1753-0407.12795
   Zheng JP, 2018, MAR DRUGS, V16, DOI 10.3390/md16020066
   Zheng YN, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0136187
   Zhu Q, 2019, BIOCHEM BIOPH RES CO, V511, P41, DOI 10.1016/j.bbrc.2019.01.058
NR 343
TC 19
Z9 21
U1 1
U2 30
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD NOV
PY 2020
VL 64
IS 22
AR 2000249
DI 10.1002/mnfr.202000249
EA OCT 2020
PG 23
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA PA5EG
UT WOS:000575943800001
PM 32978870
DA 2025-06-11
ER

PT J
AU Jung, JG
   Kim, JS
   Yoon, SJ
   Oh, MK
AF Jung, Jin-Gyu
   Kim, Jong-Sung
   Yoon, Seok-Joon
   Oh, Mi-Kyeong
TI Relationships Among Alcohol Consumption, Facial Flushing Response, and
   Metabolic Syndrome in Healthy Men
SO ANNALS OF EPIDEMIOLOGY
LA English
DT Article
DE Drinking; Flushing Response; Metabolic Syndrome
ID CORONARY-HEART-DISEASE; ALDEHYDE DEHYDROGENASE-2; LIPOPROTEIN
   SUBCLASSES; OXIDATIVE STRESS; BLOOD-PRESSURE; JAPANESE MEN; RISK;
   DRINKING; WOMEN; HYPERTENSION
AB PURPOSE: It is believed that alcohol has an intimate connection with metabolic syndrome (MS). However, the role of facial flushing after alcohol consumption in this relationship has not yet been well known. We explored the relationship between weekly alcohol consumption, risk of MS, and the flushing response.
   METHODS: The subjects were 1823 Korean adult males (305 nondrinkers, 540 flushers, 978 nonflushers) who had undergone a comprehensive medical check-up at Chungnam National University Hospital. We excluded the cases with the history of hypertension, diabetes, dyslipidemia, or who had taken medication in the previous month. After controlling for age, body mass index, exercise status, and smoking history, we used a logistic regression analysis to calculate the risk of MS with drinks per week in flushers and nonflushers as compared with nondrinkers.
   RESULTS: The risk of MS in flushers was significantly increased with alcohol consumption >4 drinks (4-16 drinks: odds ratio [OR] 1.93; > 16 drinks: OR 2.20). However, in nonflushers, the risk of MS was increased in those consuming > 16 drinks (OR 2.02).
   CONCLUSIONS: Our results suggest that the threshold for MS from alcohol consumption is lower in flushers than in nonflushers. Ann Epidemiol 2012;22:480-486. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Jung, Jin-Gyu; Kim, Jong-Sung; Yoon, Seok-Joon] Chungnam Natl Univ, Coll Med, Res Inst Med Sci, Dept Family Med, Taejon, South Korea.
   [Oh, Mi-Kyeong] Univ Ulsan, Coll Med, Gangneung Asan Hosp, Dept Family Med, Ulsan 680749, South Korea.
C3 Chungnam National University; University of Ulsan
RP Kim, JS (corresponding author), Chungnam Natl Univ Hosp, Dept Family Med, 640 Daesa Dong, Taejon 301721, South Korea.
EM josephkim@cnu.ac.kr
RI ; Kim, Seok-Hwan/G-9981-2015
OI Yoon, SeokJoon/0000-0002-6784-8191; Kim, Jong-Sung/0000-0001-5945-0784;
   Kim, Seok-Hwan/0000-0003-0209-0444
FU Chungnam National University Hospital
FX This research was supported by Chungnam National University Hospital
   Research Fund, 2010.
CR [Anonymous], 2005, The IDF consensus worldwide definition of the metabolic syndrome
   [Anonymous], 2005, FACT SHEET POCK GUID
   Carlsson S, 2005, DIABETOLOGIA, V48, P1051, DOI 10.1007/s00125-005-1768-5
   Comporti M, 2010, GENES NUTR, V5, P101, DOI 10.1007/s12263-009-0159-9
   DEFRONZO RA, 1991, DIABETES CARE, V14, P173, DOI 10.2337/diacare.14.3.173
   Fan AZ, 2008, J CLIN ENDOCR METAB, V93, P3833, DOI 10.1210/jc.2007-2788
   Foerster M, 2009, AM J CARDIOL, V103, P361, DOI 10.1016/j.amjcard.2008.09.089
   French MT, 2010, HEALTH ECON, V19, P814, DOI 10.1002/hec.1521
   Itoh T, 1997, J HYPERTENS, V15, P1211, DOI 10.1097/00004872-199715110-00004
   Ji C, 2012, BIOCHEM RES INT, V2012, DOI 10.1155/2012/216450
   Jung JG, 2010, ALCOHOL CLIN EXP RES, V34, P1699, DOI 10.1111/j.1530-0277.2010.01256.x
   Kontush A, 2005, ATHEROSCLEROSIS, V182, P277, DOI 10.1016/j.atherosclerosis.2005.03.001
   Korean National Statistical Office, KOR NAT HLTH NUTR EX
   Lieber CS, 2007, ALCOHOL CLIN EXP RES, V31, P1660, DOI 10.1111/j.1530-0277.2007.00475.x
   Liu C, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-713
   Lukasiewicz E, 2005, PUBLIC HEALTH NUTR, V8, P315, DOI 10.1079/PHN2004680
   MIZOI Y, 1983, PHARMACOL BIOCHEM BE, V18, P127, DOI 10.1016/0091-3057(83)90159-4
   Mozaffarian D, 2011, NEW ENGL J MED, V364, P2392, DOI 10.1056/NEJMoa1014296
   Mukamal KJ, 2007, J CLIN ENDOCR METAB, V92, P2559, DOI 10.1210/jc.2006-2422
   Muth ND, 2010, BRIT J NUTR, V104, P1034, DOI 10.1017/S0007114510001595
   Nishimura FT, 2002, AUTON NEUROSCI-BASIC, V102, P60, DOI 10.1016/S1566-0702(02)00206-0
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Rehm J, 2003, J CARDIOVASC RISK, V10, P15, DOI 10.1097/00043798-200302000-00004
   Rimm EB, 1999, BMJ-BRIT MED J, V319, P1523, DOI 10.1136/bmj.319.7224.1523
   Sassarini J, 2011, CLIN ENDOCRINOL, V74, P97, DOI 10.1111/j.1365-2265.2010.03921.x
   Sesso HD, 2008, HYPERTENSION, V51, P1080, DOI 10.1161/HYPERTENSIONAHA.107.104968
   Susumu H, 1991, J STUD ALCOHOL, V53, P553
   Tsumura K, 1999, DIABETES CARE, V22, P1432, DOI 10.2337/diacare.22.9.1432
   Van de Wiel A, 2012, INT J VASC MED, V2012, DOI 10.1155/2012/862504
   Wada M, 2008, J ATHEROSCLER THROMB, V15, P179, DOI 10.5551/jat.E542
   Wakabayashi I, 2006, ALCOHOL ALCOHOLISM, V41, P672, DOI 10.1093/alcalc/agl067
   Wakabayashi I, 2010, J ATHEROSCLER THROMB, V17, P695, DOI 10.5551/jat.3517
   Weigley ES, 2000, AM J CLIN NUTR, V71, P853, DOI 10.1093/ajcn/71.3.853
   World Health Organization, 2000, World Health Organ Tech Rep Ser, DOI DOI 10.1596/0-1952-1129-4
   Yokoyama A, 1997, CANCER EPIDEM BIOMAR, V6, P1105
   Yokoyama T, 2003, CANCER EPIDEM BIOMAR, V12, P1227
   YOSHIDA A, 1984, P NATL ACAD SCI-BIOL, V81, P258, DOI 10.1073/pnas.81.1.258
   Zheng LQ, 2010, J HYPERTENS, V28, P1158, DOI 10.1097/HJH.0b013e3283378568
NR 38
TC 19
Z9 19
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1047-2797
EI 1873-2585
J9 ANN EPIDEMIOL
JI Ann. Epidemiol.
PD JUL
PY 2012
VL 22
IS 7
BP 480
EP 486
DI 10.1016/j.annepidem.2012.04.014
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 959GT
UT WOS:000305301600004
PM 22575812
DA 2025-06-11
ER

PT J
AU Copeland, WE
   Shanahan, L
   Worthman, C
   Angold, A
   Costello, EJ
AF Copeland, William E.
   Shanahan, Lilly
   Worthman, Carol
   Angold, Adrian
   Costello, E. Jane
TI Cumulative Depression Episodes Predict Later C-Reactive Protein Levels:
   A Prospective Analysis
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Adolescence; childhood; CRP; depression; epidemiology; inflammation
ID CORONARY-HEART-DISEASE; CARDIOVASCULAR RISK; METABOLIC SYNDROME;
   INFLAMMATION; PREVENTION; SYMPTOMS; HEALTH; CHILD; ASSOCIATIONS;
   PREVALENCE
AB Background: Depression is associated with elevated levels of the inflammation marker C-reactive protein (CRP); yet, the direction of this association remains unclear. This study tested bi-directional longitudinal associations between CRP and depression in a sample of adolescents and young adults. The study compared the effect of current depression with the effect of cumulative episodes of depression over time.
   Methods: Nine waves of data from the prospective population-based Great Smoky Mountains Study (n = 1420) were used, covering children in the community aged 9 to 16, 19, and 21 years old. Structured interviews were used to assess depressive symptoms, depression diagnosis, and cumulative depressive episodes. Bloodspots were collected at each observation and assayed for CRP levels.
   Results: CRP levels were not associated with later depression status. In contrast, all depression-related variables displayed evidence of association with later CRP levels. The associations with depressive symptoms and diagnostic status were attenuated after controlling for covariates, particularly body mass index, smoking, and medication use. The effect of cumulative depressive episodes, however, continued to be significant after accounting for a range of covariates. Body mass index, smoking behavior, and recent infections may mediate a portion of the effect of cumulative episodes on later CRP, but cumulative depressive episodes continued to predict CRP levels independently.
   Conclusions: The occurrence of multiple depressive episodes exerted the greatest effect on later CRP levels. This suggests that risk for the diseases of middle and old age-cardiovascular and metabolic disease-may begin in childhood and depend, in part, on long-term emotional functioning.
C1 [Copeland, William E.; Angold, Adrian; Costello, E. Jane] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27710 USA.
   [Shanahan, Lilly] Univ N Carolina, Dept Psychol, Greensboro, NC 27412 USA.
   [Worthman, Carol] Emory Univ, Dept Anthropol, Atlanta, GA 30322 USA.
C3 Duke University; University of North Carolina; University of North
   Carolina Greensboro; Emory University
RP Copeland, WE (corresponding author), Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Box 3454, Durham, NC 27710 USA.
EM William.Copeland@duke.edu
RI Shanahan, Lilly/HNJ-6173-2023; Copeland, William E/N-5413-2014
OI Worthman, Carol M/0000-0002-5397-2298; Shanahan,
   Lilly/0000-0002-4534-6924; Copeland, William E/0000-0002-1348-7781
FU National Institute of Mental Health [MH63970, MH63671, MH48085,
   MH080230, MH094605]; National Institute on Drug Abuse [DA/MH11301];
   National Alliance for Research on Schizophrenia and Depression; William
   T. Grant Foundation
FX The work presented here was supported by the National Institute of
   Mental Health (MH63970, MH63671, MH48085, MH080230, MH094605), the
   National Institute on Drug Abuse (DA/MH11301), National Alliance for
   Research on Schizophrenia and Depression (Early Career Award to first
   author), and the William T. Grant Foundation.
CR Angold A, 2000, J AM ACAD CHILD PSY, V39, P975, DOI 10.1097/00004583-200008000-00009
   ANGOLD A, 1995, PSYCHOL MED, V25, P755, DOI 10.1017/S0033291700034991
   Angold A., 1999, The Young Adult Psychiatric Assessment (YAPA)
   Ascher BH, 1996, J EMOT BEHAV DISORD, V4, P12, DOI 10.1177/106342669600400102
   BARON RM, 1986, J PERS SOC PSYCHOL, V51, P1173, DOI 10.1037/0022-3514.51.6.1173
   Costello EJ, 1996, ARCH GEN PSYCHIAT, V53, P1129
   Costello EJ, 2003, ARCH GEN PSYCHIAT, V60, P837, DOI 10.1001/archpsyc.60.8.837
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   Deverts DJ, 2010, PSYCHOSOM MED, V72, P734, DOI 10.1097/PSY.0b013e3181ec4b98
   Eisenberger NI, 2010, BRAIN BEHAV IMMUN, V24, P558, DOI 10.1016/j.bbi.2009.12.009
   Elovainio M, 2006, PSYCHOL MED, V36, P797, DOI 10.1017/S0033291706007574
   Gimeno D, 2009, PSYCHOL MED, V39, P413, DOI 10.1017/S0033291708003723
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Kaptoge S, 2010, LANCET, V375, P132, DOI 10.1016/S0140-6736(09)61717-7
   Killgore WDS, 2006, NEUROREPORT, V17, P167, DOI 10.1097/01.wnr.0000198951.30939.73
   MacKinnon DP, 2002, PSYCHOL METHODS, V7, P83, DOI 10.1037/1082-989X.7.1.83
   Matthews KA, 2010, BRAIN BEHAV IMMUN, V24, P96, DOI 10.1016/j.bbi.2009.08.005
   McDade TW, 2006, PSYCHOSOM MED, V68, P376, DOI 10.1097/01.psy.0000221371.43607.64
   McDade TW, 2005, AM J PHYS ANTHROPOL, V128, P906, DOI 10.1002/ajpa.20222
   McDade TW, 2004, CLIN CHEM, V50, P652, DOI 10.1373/clinchem.2003.029488
   MCDADE W, 1997, AM J PHYS ANTHROPOL, V24, P164
   McEwen BS, 1999, ANN NY ACAD SCI, V896, P30, DOI 10.1111/j.1749-6632.1999.tb08103.x
   MCEWEN BS, 1993, ARCH INTERN MED, V153, P2093, DOI 10.1001/archinte.153.18.2093
   Mei JV, 2001, J NUTR, V131, p1631S, DOI 10.1093/jn/131.5.1631S
   Mittal VA, 2011, PSYCHIAT RES, V189, P158, DOI 10.1016/j.psychres.2011.06.006
   Musselman DL, 2001, NEW ENGL J MED, V344, P961, DOI 10.1056/NEJM200103293441303
   O'Connor MF, 2009, BRAIN BEHAV IMMUN, V23, P887, DOI 10.1016/j.bbi.2009.04.005
   Ogden CL, 2002, PEDIATRICS, V109, P45, DOI 10.1542/peds.109.1.45
   Pariante CM, 2001, BIOL PSYCHIAT, V49, P391, DOI 10.1016/S0006-3223(00)01088-X
   Pearson TA, 2003, CIRCULATION, V107, P499, DOI 10.1161/01.CIR.0000052939.59093.45
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Raison CL, 2007, ALIMENT PHARM THER, V25, P1163, DOI 10.1111/j.1365-2036.2007.03316.x
   Raison C L, 2001, Semin Clin Neuropsychiatry, V6, P277, DOI 10.1053/scnp.2001.0060277
   Raison CL, 2006, TRENDS IMMUNOL, V27, P24, DOI 10.1016/j.it.2005.11.006
   Reichenberg A, 2001, ARCH GEN PSYCHIAT, V58, P445, DOI 10.1001/archpsyc.58.5.445
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   Shah T, 2009, INT J EPIDEMIOL, V38, P217, DOI 10.1093/ije/dyn217
   Sobel ME., 1982, SOCIOL METHODOL, V13, P290, DOI DOI 10.2307/270723
   Stewart JC, 2009, BRAIN BEHAV IMMUN, V23, P936, DOI 10.1016/j.bbi.2009.04.011
   Tamakoshi K, 2003, INT J OBESITY, V27, P443, DOI 10.1038/sj.ijo.0802260
   Wagner G, 2006, BIOL PSYCHIAT, V59, P958, DOI 10.1016/j.biopsych.2005.10.025
   Williams SR, 2009, J GERONTOL B-PSYCHOL, V64, pI131, DOI 10.1093/geronb/gbn022
   Woodward M, 2003, BRIT J HAEMATOL, V122, P135, DOI 10.1046/j.1365-2141.2003.04387.x
   Worthman CM, 1997, AM J PHYS ANTHROPOL, V104, P1
NR 44
TC 198
Z9 216
U1 1
U2 31
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD JAN 1
PY 2012
VL 71
IS 1
BP 15
EP 21
DI 10.1016/j.biopsych.2011.09.023
PG 7
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 863BI
UT WOS:000298137400006
PM 22047718
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Grant, RK
   Brindle, WM
   Donnelly, MC
   McConville, PM
   Stroud, TG
   Bandieri, L
   Plevris, JN
AF Grant, Rebecca K.
   Brindle, William M.
   Donnelly, Mhairi C.
   McConville, Pauline M.
   Stroud, Thomas G.
   Bandieri, Lorenzo
   Plevris, John N.
TI Gastrointestinal and liver disease in patients with schizophrenia: A
   narrative review
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Schizophrenia; Gastrointestinal disease; Liver disease; Mental health
ID SEVERE MENTAL-ILLNESS; CELIAC-DISEASE; HEPATITIS-C; CANCER-MORTALITY;
   RISK-FACTORS; RELAPSED SCHIZOPHRENICS; PSYCHIATRIC-PATIENTS;
   HELICOBACTER-PYLORI; AUTOIMMUNE-DISEASES; METABOLIC SYNDROME
AB Schizophrenia is a severe mental illness which can have a devastating impact on an individual's quality of life. Comorbidities are high amongst patients and life expectancy is approximately 15 years less than the general population. Despite the well-known increased mortality, little is known about the impact of gastrointestinal and liver disease on patients with schizophrenia. We aimed to review the literature and to make recommendations regarding future care. Literature searches were performed on PubMed to identify studies related to gastrointestinal and liver disease in patients with schizophrenia. High rates of chronic liver disease were reported, with Non-Alcoholic Fatty Liver Disease being of particular concern; antipsychotics and metabolic syndrome were contributing factors. Rates of acute liver failure were low but have been associated with antipsychotic use and paracetamol overdose. Coeliac disease has historically been linked to schizophrenia; however, recent research suggests that a causal link is yet to be proven. Evidence is emerging regarding the relationships between schizophrenia and peptic ulcer disease, inflammatory bowel disease and irritable bowel syndrome; clinical vigilance regarding these conditions should be high. Patients with schizophrenia poorly engage with bowel cancer screening programmes, leading to late diagnosis and increased mortality. Clozapine induced constipation is a significant issue for many patients and requires close monitoring. There is a significant burden of gastrointestinal and liver disease amongst patients with schizophrenia. Better levels of support from all members of the medical team are essential to ensure that appropriate, timely care is provided.
C1 [Grant, Rebecca K.; Brindle, William M.; Donnelly, Mhairi C.; Plevris, John N.] Royal Infirm Edinburgh NHS Trust, Ctr Liver & Digest Disorders, Edinburgh EH164SA, Scotland.
   [McConville, Pauline M.; Stroud, Thomas G.; Bandieri, Lorenzo] Royal Edinburgh & Associated Hosp, Gen Adult Psychiat, Edinburgh EH105HF, Scotland.
   [Grant, Rebecca K.] Royal Infirm Edinburgh NHS Trust, Ctr Liver & Digest Disorders, 51 Little France Cres,Old Dalkeith Rd, Edinburgh EH164SA, Scotland.
C3 Royal Infirmary of Edinburgh; Royal Infirmary of Edinburgh; Royal
   Infirmary of Edinburgh
RP Grant, RK (corresponding author), Royal Infirm Edinburgh NHS Trust, Ctr Liver & Digest Disorders, 51 Little France Cres,Old Dalkeith Rd, Edinburgh EH164SA, Scotland.
EM rebecca.x.grant@nhs.scot
RI Plevris, John/O-3517-2014; Grant, Rebecca/JZD-6885-2024
OI Grant, Rebecca/0000-0002-9440-1192
CR Aaroe ASK, 2022, NORD J PSYCHIAT, V76, P114, DOI 10.1080/08039488.2021.1939779
   Archibald L, 2019, ALCOHOL RES-CURR REV, V40, P51, DOI 10.35946/arcr.v40.1.06
   Arumugam M, 2011, NATURE, V473, P174, DOI 10.1038/nature09944
   Bai W, 2021, TRANSL PSYCHIAT, V11, DOI 10.1038/s41398-021-01671-6
   Bauer-Staeb C, 2017, LANCET PSYCHIAT, V4, P685, DOI 10.1016/S2215-0366(17)30253-5
   Bender L, 1953, PSYCHIAT QUART, V27, P663, DOI 10.1007/BF01562517
   Benros ME, 2011, AM J PSYCHIAT, V168, P1303, DOI 10.1176/appi.ajp.2011.11030516
   Bernstein CN, 2019, INFLAMM BOWEL DIS, V25, P360, DOI 10.1093/ibd/izy235
   Blackman G, 2020, INT J PSYCHIAT CLIN, V24, P18, DOI 10.1080/13651501.2019.1710538
   BMJ BestPractice, METABOLIC SYNDROME
   BMJ BestPractice, COELIAC DIS
   Bobes J, 2007, SCHIZOPHR RES, V90, P162, DOI 10.1016/j.schres.2006.09.025
   Carney CP, 2006, J GEN INTERN MED, V21, P1133, DOI 10.1111/j.1525-1497.2006.00563.x
   Chang A, 2009, CAN J GASTROENTEROL, V23, P376, DOI 10.1155/2009/503916
   Chang CH, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000026218
   Chaplin AC, 2010, CAN J GASTROENTEROL, V24, P739, DOI 10.1155/2010/535026
   Chen AT, 2016, ANN CLIN PSYCHIATRY, V28, P190
   Chen SJ, 2012, BRIT J PSYCHIAT, V200, P374, DOI 10.1192/bjp.bp.111.092098
   Chougule A, 2018, J CLIN PSYCHOPHARM, V38, P42, DOI 10.1097/JCP.0000000000000824
   Clozapine, 2017, LIVERTOX CLIN RES IN
   Clozaril Connect, 2018, CLOZAPINE LIVER FUNC
   Cotton CC, 2019, CLIN TRANSL GASTROEN, V10, DOI 10.14309/ctg.0000000000000005
   Crump C, 2013, AM J PSYCHIAT, V170, P324, DOI 10.1176/appi.ajp.2012.12050599
   Deepmala, 2015, NEUROSCI BIOBEHAV R, V55, P294, DOI 10.1016/j.neubiorev.2015.04.015
   DeHert M, 1997, SCHIZOPHR RES, V26, P243, DOI 10.1016/S0920-9964(97)00069-8
   DOHAN FC, 1973, AM J PSYCHIAT, V130, P685, DOI 10.1176/ajp.130.6.685
   DOHAN FC, 1966, AM J CLIN NUTR, V18, P7, DOI 10.1093/ajcn/18.1.7
   DOHAN FC, 1969, BRIT J PSYCHIAT, V115, P595, DOI 10.1192/bjp.115.522.595
   DOHAN FC, 1984, BIOL PSYCHIAT, V19, P385
   DOHAN FC, 1978, PAVLOVIAN J BIOL SCI, V13, P73
   Eaton WW, 2004, BRIT MED J, V328, P438, DOI 10.1136/bmj.328.7437.438
   Every-Palmer S, 2019, CNS DRUGS, V33, P81, DOI 10.1007/s40263-018-0587-4
   Foskett N, 2014, PHARMACOEPIDEM DR S, V23, P276
   Freudenreich O, 2007, PSYCHOSOMATICS, V48, P405, DOI 10.1176/appi.psy.48.5.405
   Fujiwara M, 2021, ACTA PSYCHIAT SCAND, V144, P318, DOI 10.1111/acps.13348
   Fuller BE, 2011, GEN HOSP PSYCHIAT, V33, P232, DOI 10.1016/j.genhosppsych.2011.03.006
   Gao J., 2021, INTERJ GASTROENTEROL, V5, P48
   GRAFF H, 1961, PSYCHIAT QUART, V35, P306, DOI 10.1007/BF01566581
   Grant R., 2022, GUT, V71
   Gupta S, 1997, SCHIZOPHR RES, V23, P265, DOI 10.1016/S0920-9964(96)00099-0
   Hippisley-Cox J, 2007, ARCH GEN PSYCHIAT, V64, P1368, DOI 10.1001/archpsyc.64.12.1368
   Hjorthoj C, 2017, LANCET PSYCHIAT, V4, P295, DOI 10.1016/S2215-0366(17)30078-0
   Hsu JH, 2014, PSYCHOSOMATICS, V55, P163, DOI 10.1016/j.psym.2013.06.001
   Hughes E, 2016, LANCET PSYCHIAT, V3, P40, DOI 10.1016/S2215-0366(15)00357-0
   Hunt GE, 2018, DRUG ALCOHOL DEPEN, V191, P234, DOI 10.1016/j.drugalcdep.2018.07.011
   HUSSAR AE, 1968, PSYCHOSOM MED, V30, P374, DOI 10.1097/00006842-196807000-00002
   Inagaki M, 2018, TOHOKU J EXP MED, V244, P209, DOI 10.1620/tjem.244.209
   Jepsen P, 2005, ALIMENT PHARM THER, V22, P645, DOI 10.1111/j.1365-2036.2005.02638.x
   Jones GR, 2019, GUT, V68, P1953, DOI 10.1136/gutjnl-2019-318936
   Morlán-Coarasa MJ, 2016, PSYCHOPHARMACOLOGY, V233, P3947, DOI 10.1007/s00213-016-4422-7
   Kalaydjian AE, 2006, ACTA PSYCHIAT SCAND, V113, P82, DOI 10.1111/j.1600-0447.2005.00687.x
   Kao ACC, 2018, TRANSL PSYCHIAT, V8, DOI 10.1038/s41398-018-0116-8
   Kapur M, 2022, BRIT J ORAL MAX SURG, V60, P370, DOI 10.1016/j.bjoms.2022.01.001
   Kashani SA., J PSYCHOL CLINI PSYC, V7, P11
   Kelly DL, 2019, J PSYCHIATR NEUROSCI, V44, P269, DOI 10.1503/jpn.180174
   Kelly JR, 2021, SCHIZOPHR RES, V234, P4, DOI 10.1016/j.schres.2020.02.010
   Kim SR, 2019, PERSPECT PSYCHIATR C, V55, P415, DOI 10.1111/ppc.12327
   Kisely S, 2013, JAMA PSYCHIAT, V70, P209, DOI 10.1001/jamapsychiatry.2013.278
   Koreki A, 2021, J CLIN PSYCHOPHARM, V41, P474, DOI 10.1097/JCP.0000000000001421
   Laursen TM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024597
   Lee TC., 2021, TAIWANESE J PSYCHIAT, V35, P197
   Liao CH, 2014, J PSYCHOSOM RES, V77, P541, DOI 10.1016/j.jpsychores.2014.08.005
   Ludvigsson JF, 2007, SCAND J GASTROENTERO, V42, P179, DOI 10.1080/00365520600863472
   Ludvigsson JF, 2021, J CROHNS COLITIS, V15, P1824, DOI 10.1093/ecco-jcc/jjab039
   Ma QY, 2021, HEPATOL INT, V15, P127, DOI 10.1007/s12072-020-10132-z
   Macfarlane B, 1997, GASTROENTEROLOGY, V112, P1707, DOI 10.1016/S0016-5085(97)70054-4
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   MORTENSEN PB, 1993, BRIT J PSYCHIAT, V163, P183, DOI 10.1192/bjp.163.2.183
   Munawar N, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22147671
   National Institute for Health and Care Excellence (NICE), NONALCOHOLIC FATTY L
   Ni LW, 2019, BMC PSYCHIATRY, V19, DOI 10.1186/s12888-019-2332-z
   NICE, Irritable Bowel Syndrome in Adults: Diagnosis and Management
   NICE QualityStandard[QS80], 2015, PSYCHOSIS SCHIZOPHRE
   Nielsen J, 2012, SCHIZOPHRENIA BULL, V38, P592, DOI 10.1093/schbul/sbq137
   Olfson M, 2015, JAMA PSYCHIAT, V72, P1172, DOI 10.1001/jamapsychiatry.2015.1737
   Ozdemir V, 2007, J INVEST MED, V55, P315, DOI 10.2310/6650.2007.00014
   Papanastasiou E, 2013, THER ADV PSYCHOPHARM, V3, P33, DOI 10.1177/2045125312464385
   Patel RS, 2021, CUREUS J MED SCIENCE, V13, DOI 10.7759/cureus.14846
   Patrono E, 2021, BEHAV BRAIN FUNCT, V17, DOI 10.1186/s12993-021-00180-2
   Pérez-Iglesias R, 2014, INT J NEUROPSYCHOPH, V17, P41, DOI 10.1017/S1461145713001053
   Perini G, 2014, SOC PSYCH PSYCH EPID, V49, P693, DOI 10.1007/s00127-013-0765-0
   Qian L, 2022, SCHIZOPHRENIA-UK, V8, DOI 10.1038/s41537-022-00244-w
   Quetiapine, 2018, LIVERTOX CLIN RES IN
   SAKU M, 1995, INT J EPIDEMIOL, V24, P366, DOI 10.1093/ije/24.2.366
   Shirazi A, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17060863
   Siau K, 2017, J ROY COLL PHYS EDIN, V47, P218, DOI 10.4997/JRCPE.2017.303
   SIGN, 2013, SIGN 131  management of schizophrenia
   Simpson KJ, 2009, LIVER TRANSPLANT, V15, P600, DOI 10.1002/lt.21681
   Sockalingam S, 2010, SCHIZOPHR RES, V124, P86, DOI 10.1016/j.schres.2010.06.005
   Soto-Angona O, 2020, BMC MED, V18, DOI 10.1186/s12916-020-01713-8
   Sung KY, 2022, ALIMENT PHARM THER, V55, P1192, DOI 10.1111/apt.16856
   Szeligowski T, 2020, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.00156
   Taylor DM., 2018, MAUDSLEY PRESCRIBING, V13th, P193
   Tran E, 2009, CANCER-AM CANCER SOC, V115, P3555, DOI 10.1002/cncr.24383
   Uellendahl-Werth F, 2022, COMMUN BIOL, V5, DOI 10.1038/s42003-022-03031-6
   West J, 2006, ALIMENT PHARM THERAP, V23, P71, DOI 10.1111/j.1365-2036.2006.02720.x
   Wijarnpreecha K, 2018, EUR J GASTROEN HEPAT, V30, P442, DOI 10.1097/MEG.0000000000001048
   World Health Organization Schistosomiase, About us
   Xu HY, 2019, NEUROPSYCH DIS TREAT, V15, P2087, DOI 10.2147/NDT.S208061
   Yan J, 2017, NEUROPSYCH DIS TREAT, V13, P1493, DOI 10.2147/NDT.S137183
   Yilmaz Y, 2008, MED SCI MONITOR, V14, pHY13
   Zheng W, 2018, ACTA PSYCHIAT SCAND, V137, P391, DOI 10.1111/acps.12862
NR 102
TC 17
Z9 18
U1 0
U2 13
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD OCT 14
PY 2022
VL 28
IS 38
BP 5515
EP 5529
DI 10.3748/wjg.v28.i38.5515
PG 15
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 5U4OK
UT WOS:000876528000001
PM 36304087
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Halpern, B
   Mancini, MC
   de Melo, ME
   Lamounier, RN
   Moreira, RO
   Carra, MK
   Kyle, TK
   Cercato, C
   Boguszewski, CL
AF Halpern, Bruno
   Mancini, Marcio C.
   de Melo, Maria Edna
   Lamounier, Rodrigo N.
   Moreira, Rodrigo O.
   Carra, Mario K.
   Kyle, Theodore K.
   Cercato, Cintia
   Boguszewski, Cesar Luiz
TI Proposal of an obesity classification based on weight history: an
   official document by the Brazilian Society of Endocrinology and
   Metabolism (SBEM) and the Brazilian Society for the Study of Obesity and
   Metabolic Syndrome (ABESO)
SO ARCHIVES OF ENDOCRINOLOGY METABOLISM
LA English
DT Article
ID BODY-MASS INDEX; LIFE-STYLE INTERVENTION; ADIPOSE-TISSUE; WAIST
   CIRCUMFERENCE; CARDIOVASCULAR RISK; ENERGY-EXPENDITURE;
   CLINICAL-PRACTICE; AMERICAN-COLLEGE; BARIATRIC SURGERY; OLDER-ADULTS
AB Obesity is a chronic disease associated with impaired physical and mental health. A widespread view in the treatment of obesity is that the goal is to normalize the individual's body mass index (BMI). However, a modest weight loss (usually above 5%) is already associated with clinical improvement, while weight losses of 10%-15% bring even further benefits, independent from the final BMI. The percentage of weight reduction is accepted as a treatment goal since a greater decrease in weight is frequently difficult to achieve due to metabolic adaptation along with environmental and lifestyle factors. In this document, the Brazilian Society of Endocrinology and Metabolism (SBEM) and the Brazilian Society for the Study of Obesity and Metabolic Syndrome (ABESO) propose a new obesity classification based on the maximum weight attained in life (MWAL). In this classification, individuals losing a specific proportion of weight are classified as having "reduced" or "controlled" obesity. This simple classification - which is not intended to replace others but to serve as an adjuvant tool - could help disseminate the concept of clinical benefits derived from modest weight loss, allowing individuals with obesity and their health care professionals to focus on strategies for weight maintenance instead of further weight reduction. In future studies, this proposed classification can also be an important tool to evaluate possible differences in therapeutic outcomes between individuals with similar BMIs but different weight trajectories.
C1 [Halpern, Bruno] Hosp 9 Julho, Ctr Obesidade, Sao Paulo, SP, Brazil.
   [Mancini, Marcio C.; de Melo, Maria Edna; Cercato, Cintia] Univ Sao Paulo, Dept Endocrinol & Metab, Grp Obesidade & Sindrome Metab, Sao Paulo, SP, Brazil.
   [Lamounier, Rodrigo N.] Ctr Diabet Belo Horizonte, Belo Horizonte, MG, Brazil.
   [Moreira, Rodrigo O.] Inst Estadual Diabet & Endocrinol Luiz Capriglion, Rio De Janeiro, RJ, Brazil.
   [Carra, Mario K.] Univ Sao Paulo, Dept Endocrinol, Grp Diabet, Sao Paulo, SP, Brazil.
   [Kyle, Theodore K.] ConscienHealth, Pittsburgh, PA USA.
   [Cercato, Cintia] Assoc Brasileira Estudo Obesidade & Sindrome Meta, Sao Paulo, SP, Brazil.
   [Boguszewski, Cesar Luiz] Univ Fed Parana, Dept Med Interna, Serv Endocrinol & Metabol SEMPR, Curitiba, Parana, Brazil.
   [Boguszewski, Cesar Luiz] Soc Brasileira Endocrinol & Metab SBEM, Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade
   Federal do Parana
RP Halpern, B (corresponding author), Rua Alves Guimaraes 462,CJ 72-73, BR-05410000 Sao Paulo, SP, Brazil.
EM brunohalpern@hotmail.com
RI Halpern, Bruno/AAZ-7627-2020; cercato, cintia/O-9163-2017; BOGUSZEWSKI,
   CESAR/D-4603-2013; Moreira, Rodrigo/N-7131-2015; Kyle,
   Theodore/AAE-6625-2020; BOGUSZEWSKI, CESAR LUIZ/V-5661-2019
OI Kyle, Theodore/0000-0003-1119-5854; MELO, MARIA/0000-0002-1216-7532;
   Cercato, Cintia/0000-0002-6181-4951; BOGUSZEWSKI, CESAR
   LUIZ/0000-0001-7285-7941; Moreira, Rodrigo/0000-0003-1561-2926;
   Lamounier, Rodrigo/0000-0001-7432-9085; Halpern,
   Bruno/0000-0003-0973-5065; Correa Mancini, Marcio/0000-0003-1278-0406
FU Brazilian Society of Endocrinology and Metabolism (SBEM); Brazilian
   Society for the Study of Obesity and Metabolic Syndrome (ABESO)
FX the costs of this publication were equally shared by the Brazilian
   Society of Endocrinology and Metabolism (SBEM) and the Brazilian Society
   for the Study of Obesity and Metabolic Syndrome (ABESO) using their own
   resources.
CR ABESO, 2016, DIR BRAS OB 2016
   American Diabetes Association, 2018, Diabetes Care, V41, pS65, DOI 10.2337/dc18-S007
   Ardern CI, 2004, OBES RES, V12, P1094, DOI 10.1038/oby.2004.137
   Aronne LJ, 2021, OBESITY, V29, pS9, DOI 10.1002/oby.23086
   Atlantis E, 2020, OBES REV, V21, DOI 10.1111/obr.13120
   Aubin HJ, 2012, BMJ-BRIT MED J, V345, DOI 10.1136/bmj.e4439
   Bailey-Davis L, 2022, AM J CARDIOL, V162, P66, DOI 10.1016/j.amjcard.2021.09.018
   Banack HR, 2017, INT J OBESITY, V41, P1162, DOI 10.1038/ijo.2017.99
   Batsis JA, 2015, NUTR RES, V35, P1031, DOI 10.1016/j.nutres.2015.09.003
   Berthoud HR, 2021, OBESITY, V29, pS25, DOI 10.1002/oby.23080
   Berthoud HR, 2012, P NUTR SOC, V71, P478, DOI 10.1017/S0029665112000602
   Bertoluci MC, 2020, DIABETOL METAB SYNDR, V12, DOI 10.1186/s13098-020-00551-1
   Borga M, 2018, J INVEST MED, V66, P887, DOI 10.1136/jim-2018-000722
   Bray GA, 2018, ENDOCR REV, V39, P79, DOI 10.1210/er.2017-00253
   Call CC, 2019, J BEHAV MED, V42, P365, DOI 10.1007/s10865-018-9978-8
   Carlsson LMS, 2020, NEW ENGL J MED, V383, P1535, DOI 10.1056/NEJMoa2002449
   Curtis JR, 2006, ARTHRIT RHEUM-ARTHR, V55, P420, DOI 10.1002/art.21984
   Cuthbertson DJ, 2017, INT J OBESITY, V41, P853, DOI 10.1038/ijo.2017.4
   Després JP, 2012, CIRCULATION, V126, P1301, DOI 10.1161/CIRCULATIONAHA.111.067264
   DiMilia PR, 2019, CURR DIABETES REP, V19, DOI 10.1007/s11892-019-1249-8
   Dulloo AG, 2021, OBES REV, V22, DOI 10.1111/obr.13189
   Ensrud KE, 2003, J AM GERIATR SOC, V51, P1740, DOI 10.1046/j.1532-5415.2003.51558.x
   Ensrud KE, 2005, J CLIN ENDOCR METAB, V90, P1998, DOI 10.1210/jc.2004-1805
   Farpour-Lambert NJ, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00546
   Faulconbridge LF, 2012, OBESITY, V20, P783, DOI 10.1038/oby.2011.315
   Ferrannini E, 2014, AM J CLIN NUTR, V100, P996, DOI 10.3945/ajcn.114.090167
   Fildes A, 2015, AM J PUBLIC HEALTH, V105, pE54, DOI 10.2105/AJPH.2015.302773
   Flicker L, 2010, J AM GERIATR SOC, V58, P234, DOI 10.1111/j.1532-5415.2009.02677.x
   Fontaine KR, 2003, JAMA-J AM MED ASSOC, V289, P187, DOI 10.1001/jama.289.2.187
   Fothergill E, 2016, OBESITY, V24, P1612, DOI 10.1002/oby.21538
   Gafoor R, 2018, BMJ-BRIT MED J, V361, DOI 10.1136/bmj.k1951
   Gao M, 2021, LANCET DIABETES ENDO, V9, P350, DOI 10.1016/S2213-8587(21)00089-9
   Geserick M, 2018, NEW ENGL J MED, V379, P1303, DOI 10.1056/NEJMoa1803527
   Glass LM, 2015, DIGEST DIS SCI, V60, P1024, DOI 10.1007/s10620-014-3380-3
   Gregg EW, 2016, LANCET DIABETES ENDO, V4, P913, DOI 10.1016/S2213-8587(16)30162-0
   Gunderson EP, 2009, OBSTET GYN CLIN N AM, V36, P317, DOI 10.1016/j.ogc.2009.04.001
   Hall KD, 2018, MED CLIN N AM, V102, P183, DOI 10.1016/j.mcna.2017.08.012
   Halpern B, 2021, J ENDOCRINOL INVEST, V44, P877, DOI 10.1007/s40618-020-01389-0
   Halpern B, 2021, OBES REV, V22, DOI 10.1111/obr.13165
   Halpern B, 2019, AM J CLIN NUTR, V110, P1513, DOI 10.1093/ajcn/nqz249
   Halpern B, 2019, OBES REV, V20, P633, DOI 10.1111/obr.12837
   Halpern B, 2015, EXPERT OPIN DRUG SAF, V14, P185, DOI 10.1517/14740338.2015.995088
   Hamman RF, 2006, DIABETES CARE, V29, P2102, DOI 10.2337/dc06-0560
   Han TS, 2013, BEST PRACT RES CL EN, V27, P509, DOI 10.1016/j.beem.2013.04.012
   Harris KK, 2016, NAT REV ENDOCRINOL, V12, P684, DOI 10.1038/nrendo.2016.171
   Houston DK, 2018, J GERONTOL A-BIOL, V73, P1552, DOI 10.1093/gerona/glx204
   Hu Y, 2018, NEW ENGL J MED, V379, P623, DOI 10.1056/NEJMoa1803626
   Huber-Buchholz MM, 1999, J CLIN ENDOCR METAB, V84, P1470, DOI 10.1210/jc.84.4.1470
   Hunter Gary R, 2010, Int J Body Compos Res, V8, P103
   Jensen MD, 2014, J AM COLL CARDIOL, V63, P2985, DOI 10.1016/j.jacc.2013.11.004
   Jones RA, 2021, OBES REV, V22, DOI 10.1111/obr.13150
   Juonala M, 2011, NEW ENGL J MED, V365, P1876, DOI 10.1056/NEJMoa1010112
   Keith SW, 2006, INT J OBESITY, V30, P1585, DOI 10.1038/sj.ijo.0803326
   Khan SS, 2018, JAMA CARDIOL, V3, P280, DOI 10.1001/jamacardio.2018.0022
   Kitahara CM, 2014, PLOS MED, V11, DOI 10.1371/journal.pmed.1001673
   Knowler William C, 2002, N Engl J Med, V346, P393, DOI 10.1056/NEJMoa012512
   Kramer CK, 2013, ANN INTERN MED, V159, P758, DOI 10.7326/0003-4819-159-11-201312030-00008
   Kushner RF, 2020, OBESITY, V28, P9, DOI 10.1002/oby.22642
   Kusminski CM, 2016, NAT REV DRUG DISCOV, V15, P639, DOI 10.1038/nrd.2016.75
   Kyle TK, 2016, ENDOCRIN METAB CLIN, V45, P511, DOI 10.1016/j.ecl.2016.04.004
   Larsen JK, 2008, APPETITE, V50, P386, DOI 10.1016/j.appet.2007.09.002
   Lavie CJ, 2009, J AM COLL CARDIOL, V53, P1925, DOI 10.1016/j.jacc.2008.12.068
   Lazo M, 2010, DIABETES CARE, V33, P2156, DOI 10.2337/dc10-0856
   Lean MEJ, 2018, LANCET, V391, P541, DOI 10.1016/S0140-6736(17)33102-1
   LeBlanc ES, 2011, ANN INTERN MED, V155, P434, DOI 10.7326/0003-4819-155-7-201110040-00006
   LEIBEL RL, 1995, NEW ENGL J MED, V332, P621, DOI 10.1056/NEJM199503093321001
   Lemos T, 2017, CURR OPIN ENDOCRINOL, V24, P310, DOI 10.1097/MED.0000000000000360
   Lockhart SM, 2020, MED-CAMBRIDGE, V1, P33, DOI 10.1016/j.medj.2020.06.005
   Magkos F, 2016, CELL METAB, V23, P591, DOI 10.1016/j.cmet.2016.02.005
   Marchesini G, 2004, INT J OBESITY, V28, P1456, DOI 10.1038/sj.ijo.0802741
   Mason C, 2009, OBESITY, V17, P1789, DOI 10.1038/oby.2009.87
   Mechanick JI, 2017, ENDOCR PRACT, V23, P372, DOI 10.4158/EP161688.PS
   Müller TD, 2018, PHARMACOL REV, V70, P712, DOI 10.1124/pr.117.014803
   Nádas J, 2008, MED SCI MONITOR, V14, pCR15
   Neeland IJ, 2019, LANCET DIABETES ENDO, V7, P715, DOI 10.1016/S2213-8587(19)30084-1
   Ng CD, 2019, SSM-POPUL HLTH, V7, DOI 10.1016/j.ssmph.2019.100405
   Nieman LK, 2015, EUR J ENDOCRINOL, V173, pM33, DOI 10.1530/EJE-15-0464
   Okorodudu DO, 2010, INT J OBESITY, V34, P791, DOI 10.1038/ijo.2010.5
   Domecq JP, 2015, J CLIN ENDOCR METAB, V100, P363, DOI 10.1210/jc.2014-3421
   Padwal RS, 2011, CAN MED ASSOC J, V183, pE1059, DOI 10.1503/cmaj.110387
   Pasco JA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0029580
   Peterson K, 2017, J GEN INTERN MED, V32, pS56, DOI 10.1007/s11606-016-3950-5
   POULIOT MC, 1994, AM J CARDIOL, V73, P460, DOI 10.1016/0002-9149(94)90676-9
   Purcell K, 2014, LANCET DIABETES ENDO, V2, P954, DOI 10.1016/S2213-8587(14)70200-1
   Ravussin E, 2021, OBESITY, V29, pS31, DOI 10.1002/oby.23095
   Raynor HA, 2016, J ACAD NUTR DIET, V116, P129, DOI 10.1016/j.jand.2015.10.031
   Rey-López JP, 2014, OBES REV, V15, P781, DOI 10.1111/obr.12198
   Robinson E, 2015, INT J OBESITY, V39, P1721, DOI 10.1038/ijo.2015.143
   Romero-Corral A, 2008, INT J OBESITY, V32, P959, DOI 10.1038/ijo.2008.11
   Ross R, 2020, NAT REV ENDOCRINOL, V16, P177, DOI 10.1038/s41574-019-0310-7
   Rubino F, 2020, NAT MED, DOI 10.1038/s41591-020-0803-x
   Ryan DH, 2020, AM HEART J, V229, P61, DOI 10.1016/j.ahj.2020.07.008
   Ryan DH, 2017, CURR OBES REP, V6, P187, DOI 10.1007/s13679-017-0262-y
   Sasdelli AS, 2018, EAT WEIGHT DISORD-ST, V23, P205, DOI 10.1007/s40519-017-0475-9
   Schwartz MW, 2017, ENDOCR REV, V38, P267, DOI 10.1210/er.2017-00111
   SCHWARTZ RS, 1990, J GERONTOL, V45, pM181, DOI 10.1093/geronj/45.6.M181
   Sharma AM, 2009, INT J OBESITY, V33, P289, DOI 10.1038/ijo.2009.2
   Sharma AM, 2017, OBESITY, V25, P660, DOI 10.1002/oby.21801
   Sjöström L, 2007, NEW ENGL J MED, V357, P741, DOI 10.1056/NEJMoa066254
   Skyler JS, 2009, J AM COLL CARDIOL, V53, P298, DOI 10.2337/dc08-9026
   Smith GI, 2019, J CLIN INVEST, V129, P3978, DOI 10.1172/JCI129186
   Speakman JR, 2011, DIS MODEL MECH, V4, P733, DOI 10.1242/dmm.008698
   Stefan N, 2020, LANCET DIABETES ENDO, V8, P616, DOI 10.1016/S2213-8587(20)30110-8
   Stefan N, 2018, LANCET DIABETES ENDO, V6, P249, DOI 10.1016/S2213-8587(17)30292-9
   Steven S, 2016, DIABETES CARE, V39, P808, DOI 10.2337/dc15-1942
   Stuebe AM, 2009, AM J PERINAT, V26, P81, DOI 10.1055/s-0028-1103034
   Styne DM, 2017, J CLIN ENDOCR METAB, V102, P709, DOI 10.1210/jc.2016-2573
   Sumithran P, 2011, NEW ENGL J MED, V365, P1597, DOI 10.1056/NEJMoa1105816
   Taylor R, 2019, LANCET DIABETES ENDO, V7, P726, DOI 10.1016/S2213-8587(19)30076-2
   Taylor R, 2015, CLIN SCI, V128, P405, DOI 10.1042/CS20140553
   Vague J, 1996, OBES RES, V4, P204, DOI 10.1002/j.1550-8528.1996.tb00536.x
   Wadden TA, 2006, OBESITY, V14, p99S, DOI 10.1038/oby.2006.289
   Wannamethee SG, 2005, ARCH INTERN MED, V165, P1035, DOI 10.1001/archinte.165.9.1035
   Ward LC, 2019, EUR J CLIN NUTR, V73, P194, DOI 10.1038/s41430-018-0335-3
   Wharton S, 2020, CAN MED ASSOC J, V192, pE875, DOI 10.1503/cmaj.191707
   White DK, 2015, ARTHRIT CARE RES, V67, P965, DOI 10.1002/acr.22544
   Whitlock G, 2009, LANCET, V373, P1083, DOI 10.1016/S0140-6736(09)60318-4
   Wing RR, 2013, DIABETES CARE, V36, P2937, DOI 10.2337/dc13-0315
   Wing RR, 2011, DIABETES CARE, V34, P1481, DOI 10.2337/dc10-2415
   Wing RR, 2010, J SEX MED, V7, P156, DOI 10.1111/j.1743-6109.2009.01458.x
   Winter JE, 2014, AM J CLIN NUTR, V99, P875, DOI 10.3945/ajcn.113.068122
   Wood GC, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0258545
   World Health Organization (WHO), 2016, 10 FACTS OB
   Yanovski JA, 2000, NEW ENGL J MED, V342, P861, DOI 10.1056/NEJM200003233421206
   Yoshino M, 2020, NEW ENGL J MED, V383, P721, DOI 10.1056/NEJMoa2003697
   Zoungas S, 2017, LANCET DIABETES ENDO, V5, P431, DOI 10.1016/S2213-8587(17)30104-3
NR 126
TC 18
Z9 18
U1 0
U2 2
PU SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA
PI RIO DE JANEIRO, RJ
PA RUA HUMAITA, 85 CJ 501, RIO DE JANEIRO, RJ, 22261-000, BRAZIL
SN 2359-3997
EI 2359-4292
J9 ARCH ENDOCRIN METAB
JI Arch. Endocrinol. Metab.
PD MAR-APR
PY 2022
VL 66
IS 2
DI 10.20945/2359-3997000000465
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 1L0OA
UT WOS:000798991100005
PM 35420271
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Li, CB
   Li, XX
   Chang, Y
   Zhao, L
   Liu, BS
   Wei, SJ
   Xu, F
   Zhang, Y
   Chen, YG
AF Li, Chuanbao
   Li, Xiaoxing
   Chang, Ying
   Zhao, Lang
   Liu, Baoshan
   Wei, Shujian
   Xu, Feng
   Zhang, Yun
   Chen, Yuguo
TI Aldehyde Dehydrogenase-2 Attenuates Myocardial Remodeling and
   Contractile Dysfunction Induced by a High-Fat Diet
SO CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Metabolic syndrome; Myocardial remodeling; Apoptosis; ALDH2; Mice
ID INDUCED METABOLIC SYNDROME; INSULIN-RESISTANCE; LIPOTOXIC
   CARDIOMYOPATHY; OXIDATIVE STRESS; THERAPEUTIC TARGET; OVEREXPRESSION;
   EXPRESSION; OBESITY; PHOSPHORYLATION; HYPERTROPHY
AB Background/Aims: Consumption of a high-fat (HF) diet exacerbates metabolic cardiomyopathy through lipotoxic mechanisms. In this study, we explored the role of aldehyde dehydrogenase-2 (ALDH2) in myocardial damage induced by a HF diet. Methods: Wild-type C57 BL/6J mice were fed a HF diet or control diet for 16 weeks. ALDH2 overexpression was achieved by injecting a lentiviral ALDH2 expression vector into the left ventricle. Results: Consumption of a HF diet induced metabolic syndrome and myocardial remodeling, and these deleterious effects were attenuated by ALDH2 overexpression. In addition, ALDH2 overexpression attenuated the cellular apoptosis and insulin resistance associated with a HF diet. Mechanistically, ALDH2 overexpression inhibited the expression of c-Jun N-terminal kinase (JNK)-1, activated protein 1 (AP-1), insulin receptor substrate 1 (IRS-1), 4-hydroxynonenal, caspase 3, transforming growth factor beta 1, and collagen I and III, and enhanced Akt phosphorylation. Conclusion: ALDH2 may effectively attenuate myocardial remodeling and contractile defects induced by a HF diet through the regulation of the JNK/AP-1 and IRS-1/Akt signaling pathways. Our study demonstrates that ALDH2 plays an essential role in protecting cardiac function from lipotoxic cardiomyopathy. (C) 2018 The Author(s) Published by S. Karger AG, Basel
C1 [Li, Chuanbao; Chang, Ying; Liu, Baoshan; Wei, Shujian; Xu, Feng; Chen, Yuguo] Shandong Univ, Qilu Hosp, Dept Emergency Med, Jinan, Shandong, Peoples R China.
   [Li, Chuanbao; Chang, Ying; Liu, Baoshan; Wei, Shujian; Xu, Feng; Chen, Yuguo] Shandong Univ, Qilu Hosp, Chest Pain Ctr, Jinan, Shandong, Peoples R China.
   [Li, Chuanbao; Chang, Ying; Liu, Baoshan; Wei, Shujian; Xu, Feng; Chen, Yuguo] Shandong Univ, Qilu Hosp, Key Lab Emergency & Crit Care Med Shandong Prov, Jinan, Shandong, Peoples R China.
   [Li, Chuanbao; Li, Xiaoxing; Chang, Ying; Zhao, Lang; Liu, Baoshan; Wei, Shujian; Xu, Feng; Zhang, Yun; Chen, Yuguo] Shandong Univ, Chinese Minist Educ, Key Lab Cardiovasc Remodeling & Funct Res, Jinan, Shandong, Peoples R China.
   [Li, Chuanbao; Li, Xiaoxing; Chang, Ying; Zhao, Lang; Liu, Baoshan; Wei, Shujian; Xu, Feng; Zhang, Yun; Chen, Yuguo] Shandong Univ, Chinese Minist Publ Hlth, Qilu Hosp, Jinan, Shandong, Peoples R China.
   [Li, Xiaoxing] Shandong Univ, Qilu Hosp, Dept Geriatr, Jinan, Shandong, Peoples R China.
C3 Shandong University; Shandong University; Shandong University; Shandong
   University; Ministry of Education - China; Shandong University; Shandong
   University
RP Li, XX; Chen, YG (corresponding author), Shandong Univ, Qilu Hosp, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China.
EM lxx2010@126.com; yuguochen@hotmail.com
RI Li, Xiaoxing/B-9114-2008
OI Li, Xiaoxing/0000-0001-8791-7505; Xu, Feng/0000-0002-4670-3727
FU National Natural Science Foundation of China [81400282, 81570401];
   Taishan Scholar Program of Shandong Province [20130911, 20161065]; Fund
   from Department of Science and Technology of Shandong Province
   [2014GGH218004]; China Postdoctoral Science Foundation [2017M612293];
   Shandong Province Postdoctoral Special Fund [201402033]
FX This work was supported by the National Natural Science Foundation of
   China (No. 81400282 and 81570401), the Taishan Scholar Program of
   Shandong Province (No. 20130911 and 20161065), the Fund from Department
   of Science and Technology of Shandong Province (No. 2014GGH218004), the
   China Postdoctoral Science Foundation (No. 2017M612293), and the
   Shandong Province Postdoctoral Special Fund (No. 201402033). We thank
   Nathan Qi and Kavaljit Chhabra at University of Michigan for their
   language assistance.
CR Aminzadeh A, 2017, METAB BRAIN DIS, V32, P819, DOI 10.1007/s11011-017-9976-5
   Bellenger NG, 2000, EUR HEART J, V21, P1387, DOI 10.1053/euhj.2000.2011
   Bennett BL, 2003, CURR OPIN PHARMACOL, V3, P420, DOI 10.1016/S1471-4892(03)00068-7
   Budas GR, 2009, TRENDS CARDIOVAS MED, V19, P158, DOI 10.1016/j.tcm.2009.09.003
   Chiu HC, 2005, CIRC RES, V96, P225, DOI 10.1161/01.RES.0000154079.20681.B9
   Diop SB, 2015, CELL REP, V10, P1572, DOI 10.1016/j.celrep.2015.02.022
   Dirkx E, 2014, J MOL CELL CARDIOL, V76, P208, DOI 10.1016/j.yjmcc.2014.08.017
   Doser TA, 2009, CIRCULATION, V119, P1941, DOI 10.1161/CIRCULATIONAHA.108.823799
   Ebert AD, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3009027
   Erikson JM, 2017, J BIOL CHEM, V292, P2345, DOI 10.1074/jbc.M116.764522
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Jacques E, 2010, AM J PHYSIOL-LUNG C, V299, pL281, DOI 10.1152/ajplung.00360.2009
   Khairallah M, 2007, J MOL CELL CARDIOL, V43, P119, DOI 10.1016/j.yjmcc.2007.05.015
   Kim GJ, 2017, NUTRIENTS, V9
   Li CB, 2012, ACTA BIOCHIM POL, V59, P249
   Li CB, 2009, J CELL MOL MED, V13, P4444, DOI 10.1111/j.1582-4934.2008.00484.x
   Littlejohns B, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100579
   Manrique C, 2013, ENDOCRINOLOGY, V154, P3632, DOI 10.1210/en.2013-1256
   Mollica MP, 2017, DIABETES, V66, P1405, DOI 10.2337/db16-0924
   Moon DO, 2008, TOXICON, V51, P112, DOI 10.1016/j.toxicon.2007.08.015
   Musi N, 2006, ENDOCRINE, V29, P73, DOI 10.1385/ENDO:29:1:73
   Pakdeechote P, 2014, NUTRIENTS, V6, P355, DOI 10.3390/nu6010355
   Pan C, 2016, ONCOTARGET, V7, P35562, DOI 10.18632/oncotarget.9384
   Park TS, 2012, HEART FAIL CLIN, V8, P633, DOI 10.1016/j.hfc.2012.06.003
   Shyu KG, 2010, EUR J HEART FAIL, V12, P219, DOI 10.1093/eurjhf/hfq011
   Szymanska E, 2016, CELL SIGNAL, V28, P160, DOI 10.1016/j.cellsig.2015.10.002
   Turdi S, 2013, J MOL CELL CARDIOL, V55, P117, DOI 10.1016/j.yjmcc.2012.12.007
   Venkatesan B, 2010, J MOL CELL CARDIOL, V49, P655, DOI 10.1016/j.yjmcc.2010.05.007
   Wang SY, 2018, INT J OBESITY, V42, P1073, DOI 10.1038/s41366-018-0030-4
   Yamamoto W, 1994, Nihon Koshu Eisei Zasshi, V41, P230
   Yariswamy M, 2016, J BIOL CHEM, V291, P19425, DOI 10.1074/jbc.M116.724138
   Yen HW, 2017, BIOSCI BIOTECH BIOCH, V81, P979, DOI 10.1080/09168451.2017.1279848
   Yokoyama M, 2004, J BIOL CHEM, V279, P4204, DOI 10.1074/jbc.M311995200
   Zhang YM, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-40
NR 34
TC 13
Z9 16
U1 0
U2 11
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1015-8987
EI 1421-9778
J9 CELL PHYSIOL BIOCHEM
JI Cell. Physiol. Biochem.
PY 2018
VL 48
IS 5
BP 1843
EP 1853
DI 10.1159/000492506
PG 11
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA GS5WQ
UT WOS:000443744900003
PM 30092566
OA gold
DA 2025-06-11
ER

PT J
AU Campos-Peña, V
   Toral-Rios, D
   Becerril-Pérez, F
   Sánchez-Torres, C
   Delgado-Namorado, Y
   Torres-Ossorio, E
   Franco-Bocanegra, D
   Carvajal, K
AF Campos-Pena, Victoria
   Toral-Rios, Danira
   Becerril-Perez, Fernando
   Sanchez-Torres, Carmen
   Delgado-Namorado, Yair
   Torres-Ossorio, Elimar
   Franco-Bocanegra, Diana
   Carvajal, Karla
TI Metabolic Syndrome as a Risk Factor for Alzheimer's Disease: Is Aβ a
   Crucial Factor in Both Pathologies?
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
DE Alzheimer's disease; metabolic syndrome; amyloid peptide
ID AMYLOID PRECURSOR PROTEIN; INSULIN-DEGRADING ENZYME;
   CENTRAL-NERVOUS-SYSTEM; BLOOD-BRAIN-BARRIER; ANGIOTENSIN-CONVERTING
   ENZYME; GROWTH-FACTOR-I; PAIRED HELICAL FILAMENT; TRANSGENIC MOUSE
   MODEL; CELL-SURFACE RECEPTOR; COGNITIVE DECLINE
AB Significance: Recently, chronic degenerative diseases have become one of the main health problems worldwide. That is the case of Alzheimer's disease (AD) and metabolic syndrome (MetS), whose expression can be influenced by different risk factors.
   Recent Advances: In recent decades, it has been widely described that MetS increases the risk of cognitive impairment and dementia. MetS pathogenesis involves several vascular risk factors such as diabetes, dyslipidemia, hypertension, and insulin resistance (I/R).
   Critical Issues: Reported evidence shows that vascular risk factors are associated with AD, particularly in the development of protein aggregation, inflammation, oxidative stress, neuronal dysfunction, and disturbances in signaling pathways, with insulin receptor signaling being a common alteration between MetS and AD.
   Future Directions: Insulin signaling has been involved in tau phosphorylation and amyloid beta (A beta) metabolism. However, it has also been demonstrated that A beta oligomers can bind to insulin receptors, triggering their internalization, decreasing neuron responsiveness to insulin, and promoting insulin I/R. Thus, it could be argued that A beta could be a convergent factor in the development of both pathologies.
C1 [Campos-Pena, Victoria] Inst Nacl Neurol & Neurocirug, Insurgentes Sur 3877, Mexico City 14269, DF, Mexico.
   [Toral-Rios, Danira] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept Fisiol Biofis & Neurociencias, Mexico City, DF, Mexico.
   [Becerril-Perez, Fernando; Franco-Bocanegra, Diana] Univ Nacl Autonoma Mexico, Fac Ciencias, Mexico City, DF, Mexico.
   [Sanchez-Torres, Carmen] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept Biomed Mol, Mexico City, DF, Mexico.
   [Delgado-Namorado, Yair] Univ Autonoma Metropolitana, Mexico City, DF, Mexico.
   [Torres-Ossorio, Elimar] Univ Nacl Autonoma Mexico, Fac Quim, Mexico City, DF, Mexico.
   [Carvajal, Karla] Inst Nacl Pediat, Lab Nutr Expt, Mexico City, DF, Mexico.
C3 CINVESTAV - Centro de Investigacion y de Estudios Avanzados del
   Instituto Politecnico Nacional; Instituto Politecnico Nacional - Mexico;
   Universidad Nacional Autonoma de Mexico; Instituto Politecnico Nacional
   - Mexico; CINVESTAV - Centro de Investigacion y de Estudios Avanzados
   del Instituto Politecnico Nacional; Universidad Autonoma Metropolitana -
   Mexico; Universidad Nacional Autonoma de Mexico
RP Campos-Peña, V (corresponding author), Inst Nacl Neurol & Neurocirug, Insurgentes Sur 3877, Mexico City 14269, DF, Mexico.
EM neurovcp@ymail.com
RI CAMPOS-PEÑA, VICTORIA/AAR-6968-2021; Toral-Rios, Danira/J-7671-2018;
   Sanchez-Torres, Carmen/K-4713-2014
OI CAMPOS-PENA, VICTORIA/0000-0001-8282-7543; Toral-Rios,
   Danira/0000-0001-5156-6969; Sanchez-Torres, Carmen/0000-0003-0045-8233
CR Abbott NJ, 2006, NAT REV NEUROSCI, V7, P41, DOI 10.1038/nrn1824
   Abeti R, 2011, BRAIN, V134, P1658, DOI 10.1093/brain/awr104
   Abramov AY, 2004, J NEUROSCI, V24, P565, DOI 10.1523/JNEUROSCI.4042-03.2004
   Abramov AY, 2003, J NEUROSCI, V23, P5088
   Adlerz L, 2007, J BIOL CHEM, V282, P10203, DOI 10.1074/jbc.M611183200
   Alvarez AR, 2004, EXP CELL RES, V297, P186, DOI 10.1016/j.yexcr.2004.02.028
   ANDREADIS A, 1992, BIOCHEMISTRY-US, V31, P10626, DOI 10.1021/bi00158a027
   [Anonymous], 2008, LANCET
   Arbin V, 2003, J CARDIOVASC PHARM, V41, P254, DOI 10.1097/00005344-200302000-00015
   Arbin V, 2001, BRIT J PHARMACOL, V133, P495, DOI 10.1038/sj.bjp.0704098
   Ashpole NM, 2015, EXP GERONTOL, V68, P76, DOI 10.1016/j.exger.2014.10.002
   Bamberger ME, 2003, J NEUROSCI, V23, P2665
   Barbagallo M, 2014, WORLD J DIABETES, V5, P889, DOI 10.4239/wjd.v5.i6.889
   Bates KA, 2009, MOL PSYCHIATR, V14, P469, DOI 10.1038/mp.2008.96
   Becker M, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012793
   Bedse G, 2015, FRONT NEUROSCI-SWITZ, V9, DOI 10.3389/fnins.2015.00204
   Bélanger M, 2011, CELL METAB, V14, P724, DOI 10.1016/j.cmet.2011.08.016
   Bell RD, 2007, J CEREBR BLOOD F MET, V27, P909, DOI 10.1038/sj.jcbfm.9600419
   Benedict C, 2004, PSYCHONEUROENDOCRINO, V29, P1326, DOI 10.1016/j.psyneuen.2004.04.003
   Bhat R, 2003, J BIOL CHEM, V278, P45937, DOI 10.1074/jbc.M306268200
   Birch AM, 2014, BIOCHEM SOC T, V42, P1316, DOI 10.1042/BST20140171
   Blach-Olszewska Zofia, 2007, Neuropsychiatr Dis Treat, V3, P365
   BLESSED G, 1968, BRIT J PSYCHIAT, V114, P797, DOI 10.1192/bjp.114.512.797
   Bomfim TR, 2012, J CLIN INVEST, V122, P1339, DOI 10.1172/JCI57256
   Borchelt DR, 1996, NEURON, V17, P1005, DOI 10.1016/S0896-6273(00)80230-5
   Bowman GL, 2012, Curr Gerontol Geriatr Res, V2012
   Braak H, 1997, Int Psychogeriatr, V9 Suppl 1, P257, DOI 10.1017/S1041610297004973
   Braak H, 1997, INT PSYCHOGERIATR S, V9, P269, DOI DOI 10.1017/S1041610297004973
   Bravata DM, 2004, J CLIN EPIDEMIOL, V57, P1214, DOI 10.1016/j.jclinepi.2004.05.001
   Burns JM, 2012, BBA-MOL BASIS DIS, V1822, P333, DOI 10.1016/j.bbadis.2011.06.011
   Cai ZY, 2015, METAB BRAIN DIS, V30, P839, DOI 10.1007/s11011-014-9631-3
   Carro E, 2005, J NEUROSCI, V25, P10884, DOI 10.1523/JNEUROSCI.2909-05.2005
   Carro E, 2002, NAT MED, V8, P1390, DOI 10.1038/nm793
   Carson JA, 2002, J NEUROCHEM, V81, P1, DOI 10.1046/j.1471-4159.2002.00855.x
   Carvalho C, 2013, J ALZHEIMERS DIS, V35, P623, DOI 10.3233/JAD-130005
   Carvalho C, 2012, DIABETES, V61, P1234, DOI 10.2337/db11-1186
   CHARTIERHARLIN MC, 1991, NATURE, V353, P844, DOI 10.1038/353844a0
   Chung HY, 1999, J BIOL CHEM, V274, P32301, DOI 10.1074/jbc.274.45.32301
   Clarke JR, 2015, EMBO MOL MED, V7, P190, DOI 10.15252/emmm.201404183
   CLEVELAND DW, 1977, J MOL BIOL, V116, P227, DOI 10.1016/0022-2836(77)90214-5
   Cohen P, 2004, NAT REV DRUG DISCOV, V3, P479, DOI 10.1038/nrd1415
   Cole GM, 2000, MICROSC RES TECHNIQ, V50, P316, DOI 10.1002/1097-0029(20000815)50:4<316::AID-JEMT11>3.0.CO;2-E
   Cole GM, 2007, EXP GERONTOL, V42, P10, DOI 10.1016/j.exger.2006.08.009
   Combs CK, 2001, J NEUROSCI, V21, P1179
   Cook DG, 2003, AM J PATHOL, V162, P313, DOI 10.1016/S0002-9440(10)63822-9
   Cornier MA, 2008, ENDOCR REV, V29, P777, DOI 10.1210/er.2008-0024
   Correia SC, 2013, CURR ALZHEIMER RES, V10, P406
   Correia SC, 2012, BRAIN RES, V1441, P64, DOI 10.1016/j.brainres.2011.12.063
   Craft S, 2005, NEUROBIOL AGING, V26, pS65, DOI 10.1016/j.neurobiolaging.2005.08.021
   Craft S, 2003, PSYCHONEUROENDOCRINO, V28, P809, DOI 10.1016/S0306-4530(02)00087-2
   Craft S, 2007, CURR ALZHEIMER RES, V4, P147, DOI 10.2174/156720507780362137
   Craft S, 2009, ARCH NEUROL-CHICAGO, V66, P300, DOI 10.1001/archneurol.2009.27
   Crews L, 2010, HUM MOL GENET, V19, pR12, DOI 10.1093/hmg/ddq160
   Daskalopoulos EP, 2013, TRENDS CARDIOVAS MED, V23, P121, DOI 10.1016/j.tcm.2012.09.010
   de Bruijn RFAG, 2014, BMC MED, V12, DOI 10.1186/s12916-014-0130-5
   De Felice FG, 2015, FRONT AGING NEUROSCI, V7, DOI 10.3389/fnagi.2015.00094
   De Felice FG, 2014, DIABETES, V63, P2262, DOI 10.2337/db13-1954
   De Felice FG, 2013, EXPERT REV NEUROTHER, V13, P1297, DOI 10.1586/14737175.2013.864824
   De Felice FG, 2013, J CLIN INVEST, V123, P531, DOI 10.1172/JCI64595
   De Felice FG, 2009, P NATL ACAD SCI USA, V106, P1971, DOI 10.1073/pnas.0809158106
   de la Monte SM, 2014, BIOCHEM PHARMACOL, V88, P548, DOI 10.1016/j.bcp.2013.12.012
   de la Monte Suzanne M, 2008, J Diabetes Sci Technol, V2, P1101
   de la Monte SM, 2009, BMB REP, V42, P475, DOI 10.5483/BMBRep.2009.42.8.475
   De Strooper B, 2000, J CELL SCI, V113, P1857
   Deane R, 2009, CNS NEUROL DISORD-DR, V8, P16, DOI 10.2174/187152709787601867
   Demars MP, 2013, NEUROBIOL AGING, V34, P2431, DOI 10.1016/j.neurobiolaging.2013.04.016
   Deshpande A, 2006, J NEUROSCI, V26, P6011, DOI 10.1523/JNEUROSCI.1189-06.2006
   Dik MG, 2005, NEUROLOGY, V64, P1371, DOI 10.1212/01.WNL.0000158281.08946.68
   Dik MG, 2007, DIABETES CARE, V30, P2655, DOI 10.2337/dc06-1190
   Doens D, 2014, J NEUROINFLAMM, V11, DOI 10.1186/1742-2094-11-48
   Dries DR, 2008, CURR ALZHEIMER RES, V5, P132, DOI 10.2174/156720508783954695
   Duarte Ana I, 2012, J Aging Res, V2012, P384017, DOI 10.1155/2012/384017
   Duff K, 1996, NATURE, V383, P710, DOI 10.1038/383710a0
   Eikelenboom P, 2012, ALZHEIMERS RES THER, V4, DOI 10.1186/alzrt118
   Eng JA, 2004, ANN NEUROL, V55, P250, DOI 10.1002/ana.10810
   Engelhart MJ, 2004, ARCH NEUROL-CHICAGO, V61, P668, DOI 10.1001/archneur.61.5.668
   ESCH FS, 1990, SCIENCE, V248, P1122, DOI 10.1126/science.2111583
   Fakhrai-Rad H, 2000, HUM MOL GENET, V9, P2149, DOI 10.1093/hmg/9.14.2149
   Faraco G, 2016, J CEREBR BLOOD F MET, V36, P241, DOI 10.1038/jcbfm.2015.79
   Farooqui AA, 2012, CELL MOL LIFE SCI, V69, P741, DOI 10.1007/s00018-011-0840-1
   Farris W, 2003, P NATL ACAD SCI USA, V100, P4162, DOI 10.1073/pnas.0230450100
   Farris W, 2004, AM J PATHOL, V164, P1425, DOI 10.1016/S0002-9440(10)63229-4
   Fedele E, 2015, MECH AGEING DEV, V152, P1, DOI 10.1016/j.mad.2015.09.001
   Ferreira ST, 2014, ALZHEIMERS DEMENT, V10, pS76, DOI 10.1016/j.jalz.2013.12.010
   Fiala M, 1998, MOL MED, V4, P480, DOI 10.1007/BF03401753
   Floden AM, 2005, J NEUROSCI, V25, P2566, DOI 10.1523/JNEUROSCI.4998-04.2005
   Forloni G, 1993, Funct Neurol, V8, P211
   Francis GJ, 2008, BRAIN, V131, P3311, DOI 10.1093/brain/awn288
   Frisardi V, 2010, J ALZHEIMERS DIS, V21, P57, DOI 10.3233/JAD-2010-100015
   Frisardi V, 2010, AGEING RES REV, V9, P399, DOI 10.1016/j.arr.2010.04.007
   GABUZDA D, 1994, J BIOL CHEM, V269, P13623
   Gallagher EJ, 2010, MT SINAI J MED, V77, P511, DOI 10.1002/msj.20212
   Garrido JL, 2002, FASEB J, V16, P1982, DOI 10.1096/fj.02-0327fje
   Gasparini L, 2001, J NEUROSCI, V21, P2561, DOI 10.1523/JNEUROSCI.21-08-02561.2001
   Gasparini L, 2002, TRENDS PHARMACOL SCI, V23, P288, DOI 10.1016/S0165-6147(02)02037-0
   Gasperi M, 2010, J ENDOCRINOL INVEST, V33, P587, DOI 10.1007/BF03346653
   Glenner G G, 1984, Appl Pathol, V2, P357
   GLENNER GG, 1984, BIOCHEM BIOPH RES CO, V120, P885, DOI 10.1016/S0006-291X(84)80190-4
   GOATE A, 1991, NATURE, V349, P704, DOI 10.1038/349704a0
   Goedert M, 1999, BRAIN RES BULL, V50, P469, DOI 10.1016/S0361-9230(99)00138-0
   GOLDE TE, 1990, NEURON, V4, P253, DOI 10.1016/0896-6273(90)90100-T
   Grace EA, 2002, NEUROSCIENCE, V114, P265, DOI 10.1016/S0306-4522(02)00241-5
   Gralle M, 2007, PROG NEUROBIOL, V82, P11, DOI 10.1016/j.pneurobio.2007.02.001
   Gregg EW, 2000, ARCH INTERN MED, V160, P174, DOI 10.1001/archinte.160.2.174
   Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
   Grodstein F, 2001, DIABETES CARE, V24, P1060, DOI 10.2337/diacare.24.6.1060
   Grundy SM, 2004, ARTERIOSCL THROM VAS, V24, pE13, DOI 10.1161/01.ATV.0000111245.75752.C6
   Gustafson B, 2012, DIABETES, V61, P1217, DOI 10.2337/db11-1419
   Haass C, 2007, NAT REV MOL CELL BIO, V8, P101, DOI 10.1038/nrm2101
   Hafez D, 2011, AM J PATHOL, V178, P306, DOI 10.1016/j.ajpath.2010.11.012
   HILL JM, 1986, NEUROSCIENCE, V17, P1127, DOI 10.1016/0306-4522(86)90082-5
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Hirsch-Reinshagen V, 2004, J BIOL CHEM, V279, P41197, DOI 10.1074/jbc.M407962200
   Ho L, 2004, FASEB J, V18, P902, DOI 10.1096/fj.03-0978fje
   Holtzman DM, 2004, J MOL NEUROSCI, V23, P247, DOI 10.1385/JMN:23:3:247
   Holtzman DM, 2001, J MOL NEUROSCI, V17, P147, DOI 10.1385/JMN:17:2:147
   Hopkins DFC, 1997, DIABETIC MED, V14, P1044, DOI 10.1002/(SICI)1096-9136(199712)14:12<1044::AID-DIA508>3.0.CO;2-F
   Hoyer S, 2002, J NEURAL TRANSM, V109, P341, DOI 10.1007/s007020200028
   Hulse RE, 2009, VITAM HORM, V80, P635, DOI 10.1016/S0083-6729(08)00622-5
   Iqbal K, 2009, ACTA NEUROPATHOL, V118, P53, DOI 10.1007/s00401-009-0486-3
   IVERSEN LL, 1995, BIOCHEM J, V311, P1
   JARRETT JT, 1993, ANN NY ACAD SCI, V695, P144, DOI 10.1111/j.1749-6632.1993.tb23043.x
   Jiang Q, 2008, NEURON, V58, P681, DOI 10.1016/j.neuron.2008.04.010
   Jiménez-Palomares M, 2012, AM J PHYSIOL-ENDOC M, V302, pE1373, DOI 10.1152/ajpendo.00500.2011
   Jones RS, 2013, J NEUROIMMUNE PHARM, V8, P301, DOI 10.1007/s11481-012-9427-3
   Kanemitsu H, 2003, NEUROSCI LETT, V350, P113, DOI 10.1016/S0304-3940(03)00898-X
   KANG J, 1987, NATURE, V325, P733, DOI 10.1038/325733a0
   Kern W, 2001, NEUROENDOCRINOLOGY, V74, P270, DOI 10.1159/000054694
   Klein WL, 2001, TRENDS NEUROSCI, V24, P219, DOI 10.1016/S0166-2236(00)01749-5
   Kohlgruber A, 2015, CURR DIABETES REP, V15, DOI 10.1007/s11892-015-0670-x
   Korczynski W, 2006, J PHYSIOL PHARMACOL, V57, P43
   KOSIK KS, 1989, ANN MED, V21, P109, DOI 10.3109/07853898909149195
   KOUNNAS MZ, 1995, CELL, V82, P331, DOI 10.1016/0092-8674(95)90320-8
   Kruyer A, 2015, HYPERTENSION, V66, P175, DOI 10.1161/HYPERTENSIONAHA.115.05524
   Kulstad JJ, 2006, NEUROLOGY, V66, P1506, DOI 10.1212/01.wnl.0000216274.58185.09
   Lambert MP, 1998, P NATL ACAD SCI USA, V95, P6448, DOI 10.1073/pnas.95.11.6448
   Lee CYD, 2010, J NEURAL TRANSM, V117, P949, DOI 10.1007/s00702-010-0433-4
   LEVYLAHAD E, 1995, SCIENCE, V269, P973, DOI 10.1126/science.7638622
   Li SZ, 2015, EXP THER MED, V9, P2389, DOI 10.3892/etm.2015.2391
   LOO DT, 1993, P NATL ACAD SCI USA, V90, P7951, DOI 10.1073/pnas.90.17.7951
   Lourenco MV, 2013, CELL METAB, V18, P831, DOI 10.1016/j.cmet.2013.11.002
   Lucke-Wold BP, 2015, J ALZHEIMERS DIS, V43, P711, DOI 10.3233/JAD-141422
   Luque-Contreras D, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/497802
   Ma QL, 2009, J NEUROSCI, V29, P9078, DOI 10.1523/JNEUROSCI.1071-09.2009
   Majumdar A, 2007, MOL BIOL CELL, V18, P1490, DOI 10.1091/mbc.E06-10-0975
   Marques F, 2013, MOL NEURODEGENER, V8, DOI 10.1186/1750-1326-8-38
   Marr RA, 2014, FRONT AGING NEUROSCI, V6, DOI 10.3389/fnagi.2014.00187
   Marsland AL, 2010, METABOLISM, V59, P1801, DOI 10.1016/j.metabol.2010.05.015
   Mattson MP, 1997, PHYSIOL REV, V77, P1081, DOI 10.1152/physrev.1997.77.4.1081
   Mejia-Arango S, 2011, J AGING HEALTH, V23, P1050, DOI 10.1177/0898264311421199
   Meraz-Ríos MA, 2013, FRONT INTEGR NEUROSC, V7, DOI 10.3389/fnint.2013.00059
   Merlo S, 2010, TRENDS ENDOCRIN MET, V21, P537, DOI 10.1016/j.tem.2010.05.005
   Milionis HJ, 2008, CNS SPECTRUMS, V13, P606, DOI 10.1017/S1092852900016886
   Misiak B, 2012, BRAIN RES BULL, V89, P144, DOI 10.1016/j.brainresbull.2012.08.003
   Moloney AM, 2010, NEUROBIOL AGING, V31, P224, DOI 10.1016/j.neurobiolaging.2008.04.002
   Moreira PI, 2009, J ALZHEIMERS DIS, V16, P741, DOI 10.3233/JAD-2009-0972
   MURRELL J, 1991, SCIENCE, V254, P97, DOI 10.1126/science.1925564
   Nakamura T, 2010, CELL, V140, P338, DOI 10.1016/j.cell.2010.01.001
   Nalivaeva N N, 2012, Int J Alzheimers Dis, V2012, P383796, DOI 10.1155/2012/383796
   Neant-Fery M, 2008, P NATL ACAD SCI USA, V105, P9582, DOI 10.1073/pnas.0801261105
   Negash S, 2011, CURR ALZHEIMER RES, V8, P336, DOI 10.2174/156720511795745302
   NEVE RL, 1986, MOL BRAIN RES, V1, P193, DOI 10.1016/0169-328X(86)90011-2
   NEVE RL, 1986, MOL BRAIN RES, V1, P271, DOI 10.1016/0169-328X(86)90033-1
   Neve RL, 2000, BRAIN RES, V886, P54, DOI 10.1016/S0006-8993(00)02869-9
   Ott A, 1999, NEUROLOGY, V53, P1937, DOI 10.1212/WNL.53.9.1937
   Ott A, 1996, DIABETOLOGIA, V39, P1392, DOI 10.1007/s001250050588
   Ouchi N, 2011, NAT REV IMMUNOL, V11, P85, DOI 10.1038/nri2921
   Palmert M R, 1990, Adv Neurol, V51, P181
   Panza F, 2008, J NUTR HEALTH AGING, V12, P376, DOI 10.1007/BF02982669
   Panza F, 2010, J ALZHEIMERS DIS, V21, P691, DOI 10.3233/JAD-2010-091669
   Park CR, 2000, PHYSIOL BEHAV, V68, P509, DOI 10.1016/S0031-9384(99)00220-6
   Pedrós I, 2014, BBA-MOL BASIS DIS, V1842, P1556, DOI 10.1016/j.bbadis.2014.05.025
   Pérez A, 2000, NEUROCHEM RES, V25, P247, DOI 10.1023/A:1007527721160
   Prince M, 2008, INT REV PSYCHIATR, V20, P332, DOI 10.1080/09540260802094712
   Qiu WQ, 2006, NEUROBIOL AGING, V27, P190, DOI 10.1016/j.neurobiolaging.2005.01.004
   Qiu WQ, 1998, J BIOL CHEM, V273, P32730, DOI 10.1074/jbc.273.49.32730
   Querfurth HW, 2010, NEW ENGL J MED, V362, P329, DOI 10.1056/NEJMra0909142
   Raffaitin C, 2009, DIABETES CARE, V32, P169, DOI 10.2337/dc08-0272
   Rasouli N, 2007, DIABETES OBES METAB, V9, P1, DOI 10.1111/j.1463-1326.2006.00590.x
   Reger MA, 2008, NEUROLOGY, V70, P440, DOI 10.1212/01.WNL.0000265401.62434.36
   Rice GI, 2006, HYPERTENSION, V48, P914, DOI 10.1161/01.HYP.0000244543.91937.79
   Ríos JA, 2014, PROG NEUROBIOL, V121, P125, DOI 10.1016/j.pneurobio.2014.07.004
   Rivera EJ, 2005, J ALZHEIMERS DIS, V8, P247
   Saido T, 2012, CSH PERSPECT MED, V2, DOI 10.1101/cshperspect.a006379
   SANDBRINK R, 1994, J BIOL CHEM, V269, P14227
   Schmidt R, 2002, ANN NEUROL, V52, P168, DOI 10.1002/ana.10265
   Schubert M, 2004, P NATL ACAD SCI USA, V101, P3100, DOI 10.1073/pnas.0308724101
   Schubert M, 2003, J NEUROSCI, V23, P7084, DOI 10.1523/JNEUROSCI.23-18-07084.2003
   SCHWEERS O, 1994, J BIOL CHEM, V269, P24290
   Sebastiao I, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00110
   SELKOE DJ, 1994, ANNU REV NEUROSCI, V17, P489, DOI 10.1146/annurev.ne.17.030194.002421
   Shankar GM, 2007, J NEUROSCI, V27, P2866, DOI 10.1523/JNEUROSCI.4970-06.2007
   Sims-Robinson C, 2010, NAT REV NEUROL, V6, P551, DOI 10.1038/nrneurol.2010.130
   SISODIA SS, 1990, SCIENCE, V248, P492, DOI 10.1126/science.1691865
   Sisodia SS, 1999, AM J HUM GENET, V65, P7, DOI 10.1086/302475
   Snyder EM, 2005, NAT NEUROSCI, V8, P1051, DOI 10.1038/nn1503
   Solano DC, 2000, FASEB J, V14, P1015, DOI 10.1096/fasebj.14.7.1015
   Solfrizzi V, 2004, NEUROLOGY, V63, P1882, DOI 10.1212/01.WNL.0000144281.38555.E3
   Solfrizzi V, 2011, NEUROBIOL AGING, V32, P1932, DOI 10.1016/j.neurobiolaging.2009.12.012
   Solito E, 2012, FRONT PHARMACOL, V3, DOI 10.3389/fphar.2012.00014
   Stamatovic SM, 2008, CURR NEUROPHARMACOL, V6, P179, DOI 10.2174/157015908785777210
   Stampfer MJ, 2006, J INTERN MED, V260, P211, DOI 10.1111/j.1365-2796.2006.01687.x
   Standeven KF, 2011, INT J OBESITY, V35, P1031, DOI 10.1038/ijo.2010.227
   Takahashi S, 2003, J BIOL CHEM, V278, P10506, DOI 10.1074/jbc.M211964200
   Tarczyluk MA, 2015, J CEREBR BLOOD F MET, V35, P1348, DOI 10.1038/jcbfm.2015.58
   Toledo EM, 2010, MOL PSYCHIATR, V15, P272, DOI 10.1038/mp.2009.72
   Toral-Rios D, 2015, FRONT CELL NEUROSCI, V9, DOI 10.3389/fncel.2015.00148
   Turner PR, 2003, PROG NEUROBIOL, V70, P1, DOI 10.1016/S0301-0082(03)00089-3
   van der Heide LP, 2006, PROG NEUROBIOL, V79, P205, DOI 10.1016/j.pneurobio.2006.06.003
   van Dijk G, 2008, EUR J PHARMACOL, V585, P137, DOI 10.1016/j.ejphar.2007.11.079
   van Dijk G, 2015, FRONT NEUROSCI-SWITZ, V9, DOI 10.3389/fnins.2015.00173
   Vekrellis K, 2000, J NEUROSCI, V20, P1657
   Visser M, 1999, JAMA-J AM MED ASSOC, V282, P2131, DOI 10.1001/jama.282.22.2131
   Wahrle SE, 2005, J BIOL CHEM, V280, P43236, DOI 10.1074/jbc.M508780200
   Walsh DM, 2004, PROTEIN PEPTIDE LETT, V11, P213, DOI 10.2174/0929866043407174
   Wang DS, 2006, J BIOMED BIOTECHNOL, DOI 10.1155/JBB/2006/58406
   Watanabe T, 2005, J AM GERIATR SOC, V53, P1748, DOI 10.1111/j.1532-5415.2005.53524.x
   Watts AS, 2013, J ALZHEIMERS DIS, V35, P253, DOI 10.3233/JAD-121168
   Weiss N, 2009, BBA-BIOMEMBRANES, V1788, P842, DOI 10.1016/j.bbamem.2008.10.022
   Williamson R, 2012, BIOCHEM PHARMACOL, V84, P737, DOI 10.1016/j.bcp.2012.05.007
   WISCHIK CM, 1988, P NATL ACAD SCI USA, V85, P4506, DOI 10.1073/pnas.85.12.4506
   WONG CW, 1985, P NATL ACAD SCI USA, V82, P8729, DOI 10.1073/pnas.82.24.8729
   Wyss-Coray T, 2003, NAT MED, V9, P453, DOI 10.1038/nm838
   Yaffe K, 2004, JAMA-J AM MED ASSOC, V292, P2237, DOI 10.1001/jama.292.18.2237
   Yaffe K, 2007, J AM GERIATR SOC, V55, P758, DOI 10.1111/j.1532-5415.2007.01139.x
   Yamada M, 2000, NEUROPATHOLOGY, V20, P8, DOI 10.1046/j.1440-1789.2000.00268.x
   Yang JYO, 2009, AM J PHYSIOL-HEART C, V296, pH1850, DOI 10.1152/ajpheart.01199.2008
   Yfanti C, 2008, INT J MOL MED, V22, P421, DOI 10.3892/ijmm_00000038
   Zhang Y, 2013, DIABETES, V62, P1159, DOI 10.2337/db12-0670
   Zhao WQ, 2009, BBA-MOL BASIS DIS, V1792, P482, DOI 10.1016/j.bbadis.2008.10.014
   Zhou D, 2012, OBESITY, V20, P1577, DOI 10.1038/oby.2012.42
   Zlokovic BV, 2005, BRAIN PATHOL, V15, P78
   Zou K, 2008, REV NEUROSCIENCE, V19, P203
NR 233
TC 47
Z9 49
U1 0
U2 18
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD APR
PY 2017
VL 26
IS 10
BP 542
EP +
DI 10.1089/ars.2016.6768
PG 20
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA EP7PX
UT WOS:000397570800004
PM 27368351
DA 2025-06-11
ER

PT J
AU Martins, CC
   Bagatini, MD
   Cardoso, AM
   Zanini, D
   Abdalla, FH
   Baldissarelli, J
   Dalenogare, DP
   Farinha, JB
   Schetinger, MRC
   Morsch, VM
AF Martins, Caroline Curry
   Bagatini, Margarete Dulce
   Cardoso, Andreia Machado
   Zanini, Daniela
   Abdalla, Fatima Husein
   Baldissarelli, Jucimara
   Dalenogare, Diessica Padilha
   Farinha, Juliano Boufleur
   Chitolina Schetinger, Maria Rosa
   Morsch, Vera Maria
TI Regular exercise training reverses ectonucleotidase alterations and
   reduces hyperaggregation of platelets in metabolic syndrome patients
SO CLINICA CHIMICA ACTA
LA English
DT Article
DE Metabolic syndrome; Ectonucleotidases; Exercise training; Platelet
   aggregation
ID ADENINE-NUCLEOTIDE HYDROLYSIS; OXIDATIVE STRESS; SKELETAL-MUSCLE;
   SYNAPTOSOMES; AGGREGATION; NTPDASE; DISEASE; IMPACT; RATS; ATP
AB Background: Alterations in the activity of ectonucleotidase enzymes have been implicated in cardiovascular diseases, whereas regular exercise training has been shown to prevent these alterations. However, nothing is known about it relating to metabolic syndrome (MetS). We investigated the effect of exercise training on platelet ectonucleotidase enzymes and on the aggregation profile of MetS patients.
   Methods: We studied 38 MetS patients who performed regular concurrent exercise training for 30 weeks. Anthropometric measurements, biochemical profiles, hydrolysis of adenine nucleotides in platelets and platelet aggregation were collected from patients before and after the exercise intervention as well as from individuals of the control group.
   Results: An increase in the hydrolysis of adenine nucleotides (ATP, ADP and AMP) and a decrease in adenosine deamination in the platelets of MetS patients before the exercise intervention were observed (P < 0.001). However, these alterations were reversed by exercise training (P < 0.001). Additionally, an increase in platelet aggregation was observed in the MetS patients (P < 0.001) and the exercise training prevented platelet hyperaggregation in addition to decrease the classic cardiovascular risks.
   Conclusions: An alteration of ectonucleotidase enzymes occurs during MetS, whereas regular exercise training had a protective effect on these enzymes and on platelet aggregation. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Martins, Caroline Curry; Bagatini, Margarete Dulce; Cardoso, Andreia Machado; Zanini, Daniela; Abdalla, Fatima Husein; Baldissarelli, Jucimara; Dalenogare, Diessica Padilha; Farinha, Juliano Boufleur; Chitolina Schetinger, Maria Rosa; Morsch, Vera Maria] Univ Fed Santa Maria, Ctr Nat & Exact Sci, Dept Biochem & Mol Biol, Postgrad Program Toxicol Biochem, BR-97119900 Santa Maria, RS, Brazil.
   [Bagatini, Margarete Dulce] Univ Southern Frontier, Collegiate Nursing, Chapeco Campus, SC, Brazil.
   [Farinha, Juliano Boufleur] Univ Fed Santa Maria, Ctr Phys Educ & Sports, Phys Act Grp, BR-97119900 Santa Maria, RS, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal de
   Santa Maria (UFSM)
RP Morsch, VM (corresponding author), Univ Fed Santa Maria, Ctr Nat & Exact Sci, Dept Biochem & Mol Biol, Postgrad Program Toxicol Biochem, BR-97119900 Santa Maria, RS, Brazil.
EM veramorsch@gmail.com
RI Padilha Dalenogare, Diéssica/IUM-5367-2023; Schetinger,
   Maria/JAC-4640-2023; Cardoso, Andréia/ABH-9732-2020; Morsch,
   Vera/M-6215-2014; Farinha, Juliano/HDN-8796-2022; Zanini,
   Daniela/KEH-7499-2024; Bagatini, Margarete/K-3756-2016; Baldissarelli,
   Jucimara/U-4563-2017
OI Bagatini, Margarete/0000-0001-9263-4980; Boufleur Farinha,
   Juliano/0000-0003-4589-256X; Cardoso, Andreia/0000-0003-4243-8855;
   Chitolina Schetinger, Maria Rosa/0000-0002-5240-8935; Baldissarelli,
   Jucimara/0000-0002-1114-0063; Morsch, Vera Maria/0000-0002-5381-4556
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
   [304641/2013-8]; Fundacao de Amparo a Pesquisa do Rio Grande do Sul
   (FAPERGS) [1279-2551/13-7]; Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior (CAPES); FINEP research grant "Rede Institute Brasileiro
   de Neurociencia (IBN-Net)"; "Instituto Nacional de Ciencia e Tecnologia"
   (INCT)
FX The authors wish to thank the Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq: grant number 304641/2013-8), Fundacao de
   Amparo a Pesquisa do Rio Grande do Sul (FAPERGS: grant number
   1279-2551/13-7), Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior (CAPES), the FINEP research grant "Rede Institute Brasileiro de
   Neurociencia (IBN-Net)" and "Instituto Nacional de Ciencia e Tecnologia"
   (INCT) for their financial support of this work.
CR Anwar J, 2013, FOOD CHEM TOXICOL, V56, P459, DOI 10.1016/j.fct.2013.02.030
   Bagatini MD, 2008, CLIN BIOCHEM, V41, P1181, DOI 10.1016/j.clinbiochem.2008.07.008
   Bagatini MD, 2011, CLIN CHIM ACTA, V412, P159, DOI 10.1016/j.cca.2010.09.033
   Blackburn MR, 2005, ADV IMMUNOL, V86, P1, DOI 10.1016/S0065-2776(04)86001-2
   BORN GVR, 1962, NATURE, V194, P927, DOI 10.1038/194927b0
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Brzycki M., 1993, JOPERD, V64, P88, DOI [10.1080/07303084.1993.10606684, DOI 10.1080/07303084.1993.10606684]
   Buscemi S, 2014, EAT WEIGHT DISORD-ST, V19, P225, DOI 10.1007/s40519-014-0117-4
   Campos JC, 2013, FOOD CHEM TOXICOL, V62, P107, DOI 10.1016/j.fct.2013.08.035
   Cardoso AM, 2012, MOL CELL BIOCHEM, V371, P147, DOI 10.1007/s11010-012-1431-7
   CHAN KM, 1986, ANAL BIOCHEM, V157, P375, DOI 10.1016/0003-2697(86)90640-8
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Colato A, 2014, J EXERC SCI FIT, V12, P55, DOI 10.1016/j.jesf.2014.06.002
   Colgan Sean P, 2006, Purinergic Signal, V2, P351, DOI 10.1007/s11302-005-5302-5
   de Meirelles LR, 2014, EUR J PREV CARDIOL, V21, P1225, DOI 10.1177/2047487313491662
   Fürstenau CR, 2006, PLATELETS, V17, P84, DOI 10.1080/09537100500246641
   Grundy SM, 2006, DIABETES CARE, V29, P1689, DOI 10.2337/dc05-2307
   Guisti, 1984, Methods of enzymatic analysis, V2nd, P315
   Hutcheson R, 2012, EXP DIABETES RES, DOI 10.1155/2012/271028
   Kannan S, 2003, CELL BIOL INT, V27, P153, DOI 10.1016/S1065-6995(02)00296-2
   Kim DY, 2014, J PHYS THER SCI, V26, P1825, DOI 10.1589/jpts.26.1825
   Le GY, 2014, BIOCHEM BIOPH RES CO, V450, P93, DOI 10.1016/j.bbrc.2014.05.066
   Li JH, 2005, CIRCULATION, V111, P2748, DOI 10.1161/CIRCULATIONAHA.104.510669
   Lunkes DS, 2009, THROMB RES, V124, P268, DOI 10.1016/j.thromres.2008.12.004
   Lunkes GI, 2003, THROMB RES, V109, P189, DOI 10.1016/S0049-3848(03)00178-6
   Malin SK, 2012, ANN NUTR METAB, V61, P135, DOI 10.1159/000342084
   Marcus AJ, 2003, J THROMB HAEMOST, V1, P2497, DOI 10.1111/j.1538-7836.2003.00479.x
   Mizuno M, 2005, NUCL MED BIOL, V32, P831, DOI 10.1016/j.nucmedbio.2005.07.003
   Olufadi R, 2006, PATHOPHYSIOL HAEMO T, V35, P281, DOI 10.1159/000093221
   Pilla C, 1996, PLATELETS, V7, P225, DOI 10.3109/09537109609023582
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Robson Simon C, 2006, Purinergic Signal, V2, P409, DOI 10.1007/s11302-006-9003-5
   Russo Isabella, 2012, SCIENTIFICA, V2012, P1, DOI DOI 10.6064/2012/525374
   Sadikot S, 2010, DIABETES METAB SYND, V4, P111, DOI 10.1016/j.dsx.2010.05.011
   Santilli F, 2012, OBES REV, V13, P27, DOI 10.1111/j.1467-789X.2011.00930.x
   Schetinger MRC, 2007, BIOFACTORS, V31, P77, DOI 10.1002/biof.5520310205
   Schmatz R, 2013, CELL BIOCHEM BIOPHYS, V65, P129, DOI 10.1007/s12013-012-9407-5
   Shah B, 2012, DIABETES CARE, V35, P1074, DOI 10.2337/dc11-1724
   Shephard RJ, 1999, CIRCULATION, V99, P963, DOI 10.1161/01.CIR.99.7.963
   Siqueira IR, 2010, BRAIN RES, V1316, P173, DOI 10.1016/j.brainres.2009.11.076
   Spanevello R, 2009, BRAIN RES BULL, V80, P45, DOI 10.1016/j.brainresbull.2009.05.015
   Stefan C, 2005, TRENDS BIOCHEM SCI, V30, P542, DOI 10.1016/j.tibs.2005.08.005
   van der Stoep M, 2014, CARDIOVASC RES, V103, P362, DOI 10.1093/cvr/cvu137
   Vidigal FD, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-1198
   Wareham NJ, 1998, BRIT J NUTR, V80, P235, DOI 10.1017/S0007114598001287
   Yegutkin GG, 2008, BBA-MOL CELL RES, V1783, P673, DOI 10.1016/j.bbamcr.2008.01.024
NR 46
TC 13
Z9 14
U1 0
U2 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD FEB 15
PY 2016
VL 454
BP 66
EP 71
DI 10.1016/j.cca.2015.12.024
PG 6
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA DE0HN
UT WOS:000370305800013
PM 26719035
OA hybrid
DA 2025-06-11
ER

PT J
AU Han, DH
   Lim, S
   Paek, D
   Kim, HD
AF Han, Dong-Hun
   Lim, Sinye
   Paek, Domyung
   Kim, Hyun-Duck
TI Periodontitis could be related factors on metabolic syndrome among
   Koreans: a case-control study
SO JOURNAL OF CLINICAL PERIODONTOLOGY
LA English
DT Article
DE epidemiology; Korean; metabolic syndrome; periodontitis
ID INTERNATIONAL-DIABETES-FEDERATION; BANWOL ENVIRONMENTAL-HEALTH;
   OXIDATIVE STRESS; GLYCEMIC CONTROL; NATIONAL-HEALTH; UNITED-STATES;
   ORAL-HEALTH; NHANES-III; DISEASE; INFLAMMATION
AB Aim: Several studies have suggested that metabolic disorders are related to periodontitis. The objective of this study is to assess whether periodontitis is associated with the metabolic syndrome (MetS) among Koreans.
   Material and Methods: This case-control study was performed among 167 cases with MetS and 166 healthy controls from Shiwha-Banwol Environmental Health Cohort (N = 1853). The community periodontal index (CPI) was used to assess periodontitis (CPI 3-4). MetS was an outcome variable and periodontitis was a main explanatory variable. Age-gender-matched conditional logistic regression models were applied. Monthly household income, smoking, drinking, physical activity and diabetes mellitus were factored as confounders. We also performed stratified analyses according to confounders.
   Results: Those with periodontitis are more likely to be patients with MetS than those without periodontitis. The adjusted odds ratio of periodontitis for MetS was 1.76. There was no significant dose-effect response on the relationship between the number of sextants with periodontitis and MetS. Links became higher in adults aged 45-60 years and adults without diabetes mellitus.
   Conclusions: These results suggest that periodontitis could be an independently related factor on MetS. Hence, dentists and physicians should be aware of the importance of periodontitis as a potential source of inflammatory burden.
C1 [Han, Dong-Hun; Kim, Hyun-Duck] Seoul Natl Univ, Dept Prevent & Social Dent, Sch Dent, Seoul 110749, South Korea.
   [Han, Dong-Hun; Kim, Hyun-Duck] Seoul Natl Univ, Dent Res Inst, Sch Dent, Seoul 110749, South Korea.
   [Lim, Sinye] Kyung Hee Univ, Dept Occupat & Environm Med, Med Ctr, Seoul, South Korea.
   [Paek, Domyung] Seoul Natl Univ, Dept Environm & Occupat Med, Sch Publ Hlth, Seoul 110749, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU); Kyung
   Hee University; Seoul National University (SNU)
RP Han, DH (corresponding author), Seoul Natl Univ, Dept Prevent & Social Dent, Sch Dent, 28 Yeongeon Dong, Seoul 110749, South Korea.
EM hyundkim@snu.ac.kr
RI Paek, Domyung/D-5747-2012; Han, Dong-Hun/B-2140-2014
FU Ministry of Environment, Korea [90020060032]; Korea Science and
   Engineering Foundation (KOSEF) of the Ministry of Education, Science and
   Technology, Korea [2010-0014141]; National Research Foundation of Korea,
   through the Oromaxillofacial Dysfunction Research Center for the Elderly
   at Seoul National University, Korea [2010-0029479]
FX This work was supported by the grant of the Ministry of Environment,
   Korea (90020060032), the Korea Science and Engineering Foundation
   (KOSEF) grant of the Ministry of Education, Science and Technology,
   Korea (No. 2010-0014141) and the National Research Foundation of Korea
   Grant, through the Oromaxillofacial Dysfunction Research Center for the
   Elderly (No. 2010-0029479) at Seoul National University, Korea.
CR Akahn FA, 2009, J PERIODONTOL, V80, P457, DOI [10.1902/jop.2009.080218, 10.1902/jop.2009.080218 ]
   Albandar JM, 1999, J PERIODONTOL, V70, P13, DOI 10.1902/jop.1999.70.1.13
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Baltacioglu E, 2008, ARCH ORAL BIOL, V53, P716, DOI 10.1016/j.archoralbio.2008.02.002
   Bergstrom Jan, 2006, J Evid Based Dent Pract, V6, P33, DOI 10.1016/j.jebdp.2005.12.018
   Cameron AJ, 2004, ENDOCRIN METAB CLIN, V33, P351, DOI 10.1016/j.ecl.2004.03.005
   D'Aiuto F, 2008, J CLIN ENDOCR METAB, V93, P3989, DOI 10.1210/jc.2007-2522
   Dalla Vecchia CF, 2005, J PERIODONTOL, V76, P1721, DOI 10.1902/jop.2005.76.10.1721
   Dandona P, 2002, DIABETOLOGIA, V45, P924, DOI 10.1007/s00125-001-0766-5
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   Franek E, 2009, AM J HYPERTENS, V22, P203, DOI 10.1038/ajh.2008.330
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Ghanim H, 2004, CIRCULATION, V110, P1564, DOI 10.1161/01.CIR.0000142055.53122.FA
   Grossi S G, 1998, Ann Periodontol, V3, P51, DOI 10.1902/annals.1998.3.1.51
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   한동헌, 2009, [Journal of Korean Academy of Oral Health, 대한구강보건학회지], V33, P634
   Han DH, 2010, J CLIN PERIODONTOL, V37, P609, DOI 10.1111/j.1600-051X.2010.01580.x
   Han DH, 2010, J CLIN PERIODONTOL, V37, P172, DOI 10.1111/j.1600-051X.2009.01515.x
   Han DH, 2009, J PERIODONTOL, V80, P1928, DOI 10.1902/jop.2009.090293
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Higashi Y, 2008, HYPERTENSION, V51, P446, DOI 10.1161/HYPERTENSIONAHA.107.101535
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Hwang LC, 2007, EUR J EPIDEMIOL, V22, P899, DOI 10.1007/s10654-007-9183-5
   Kingman A, 2002, PERIODONTOL 2000, V29, P11, DOI 10.1034/j.1600-0757.2002.290102.x
   Kocher T, 2005, J CLIN PERIODONTOL, V32, P59, DOI 10.1111/j.1600-051X.2004.00629.x
   Lee SY, 2007, DIABETES RES CLIN PR, V75, P72, DOI 10.1016/j.diabres.2006.04.013
   Li P, 2009, J PERIODONTOL, V80, P541, DOI 10.1902/jop.2009.080387
   Li XJ, 2000, CLIN MICROBIOL REV, V13, P547, DOI 10.1128/CMR.13.4.547-558.2000
   Lim S, 2005, DIABETES CARE, V28, P1810, DOI 10.2337/diacare.28.7.1810
   Lorenzo C, 2007, DIABETES CARE, V30, P8, DOI 10.2337/dc06-1414
   Mealey BL, 2007, PERIODONTOL 2000, V44, P127, DOI 10.1111/j.1600-0757.2006.00193.x
   Moeintaghavi Amir, 2005, J Contemp Dent Pract, V6, P78
   Montebugnoli L, 2004, J CLIN PERIODONTOL, V31, P25, DOI 10.1111/j.0303-6979.2004.00432.x
   Ojima M, 2006, J PERIODONTAL RES, V41, P573, DOI 10.1111/j.1600-0765.2006.00915.x
   Rajala MW, 2003, ENDOCRINOLOGY, V144, P3765, DOI 10.1210/en.2003-0580
   Rothman KJ, 2008, MODERN EPIDEMIOLOGY, P175
   Statement P., 2007, Diabetes Care, V30, DOI [DOI 10.2337/DC07-S004, 10.2337/dc07-S004]
   Taylor GW, 2008, ORAL DIS, V14, P191, DOI 10.1111/j.1601-0825.2008.01442.x
   Teeuw WJ, 2010, DIABETES CARE, V33, P421, DOI 10.2337/dc09-1378
   Tomar SL, 2000, J PERIODONTOL, V71, P743, DOI 10.1902/jop.2000.71.5.743
   Tripathy D, 2003, DIABETES, V52, P2882, DOI 10.2337/diabetes.52.12.2882
   Vidal F, 2009, J PERIODONTOL, V80, P786, DOI 10.1902/jop.2009.080471
   Warnakulasuriya S, 2010, INT DENT J, V60, P7, DOI 10.1922/IDJ_2532Warnakulasuriya24
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   WHO, 1997, OR HLTH SURV BAS MET, P41
   Wood N, 2003, J CLIN PERIODONTOL, V30, P321, DOI 10.1034/j.1600-051X.2003.00353.x
NR 47
TC 35
Z9 39
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-6979
EI 1600-051X
J9 J CLIN PERIODONTOL
JI J. Clin. Periodontol.
PD JAN
PY 2012
VL 39
IS 1
BP 30
EP 37
DI 10.1111/j.1600-051X.2011.01806.x
PG 8
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA 861IP
UT WOS:000298012900004
PM 22092822
DA 2025-06-11
ER

PT J
AU Azfar, RS
   Gelfand, JM
AF Azfar, Rahat S.
   Gelfand, Joel M.
TI Psoriasis and metabolic disease: epidemiology and pathophysiology
SO CURRENT OPINION IN RHEUMATOLOGY
LA English
DT Review
DE epidemiology; inflammation; metabolic syndrome; myocardial infarction;
   psoriasis
ID GROWTH-FACTOR-II; CARDIOVASCULAR-DISEASE; RISK-FACTORS; OBESITY;
   ATHEROSCLEROSIS; SUSCEPTIBILITY; PROLIFERATION; HOMOCYSTEINE;
   ASSOCIATION; DYSFUNCTION
AB Purpose of review The scientific literature linking psoriasis to metabolic syndrome, and its components, as well as atherosclerosis and myocardial infarction has rapidly expanded. Increasingly, epidemiological studies are establishing the directionality of these associations and psoriasis' role as an independent risk factor in developing these outcomes.
   Recent findings Psoriasis is associated with metabolic syndrome, and its components, such as obesity, diabetes, and hypertension. Obesity has been shown to be an independent risk factor for the development of psoriasis, and is also associated with more severe psoriasis. Psoriasis is associated with diabetes, coronary artery disease, and an increased risk for myocardial infarction independent of traditional risk factors for these disorders. These phenotypically diverse conditions share similar pathologic changes such as chronic inflammation, angiogenesis, oxidative stress, and selected susceptibility genes and loci.
   Summary The broad literature linking psoriasis to metabolic disorders has led to changes in standard of care recommendations for patients with psoriasis. In particular, practitioners are encouraged to screen psoriasis patients, especially when disease is severe, for metabolic disorders and cardiovascular risk factors and institute appropriate prevention strategies. Additional studies investigating the role of psoriasis activity and severity as an independent risk factor for developing metabolic disorders, atherosclerosis, and myocardial infarction and the role of psoriasis treatment in altering the risk of developing these serious morbidities are urgently needed.
C1 [Azfar, Rahat S.; Gelfand, Joel M.] Univ Penn, Dept Dermatol, Philadelphia, PA 19104 USA.
   [Gelfand, Joel M.] Univ Penn, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; University of Pennsylvania
RP Gelfand, JM (corresponding author), 3600 Spruce St,2 Maloney Bldg, Philadelphia, PA 19104 USA.
EM Joel.Gelfand@uphs.upenn.edu
OI Gelfand, Joel/0000-0003-3480-2661
FU NIAMS NIH HHS [K23 AR051125, F32 AR056799, K23-AR051125] Funding Source:
   Medline
CR Akhyani M, 2007, J EUR ACAD DERMATOL, V21, P1330, DOI 10.1111/j.1468-3083.2007.02260.x
   Arican O, 2005, MEDIAT INFLAMM, P273, DOI 10.1155/MI.2005.273
   Boehncke S, 2007, BRIT J DERMATOL, V157, P1249, DOI 10.1111/j.1365-2133.2007.08190.x
   Bowden DW, 2006, DIABETES, V55, P1985, DOI 10.2337/db06-0003
   Campalani E, 2006, BRIT J DERMATOL, V154, P345, DOI 10.1111/j.1365-2133.2005.06950.x
   Cao Y, 2007, J CLIN INVEST, V117, P2362, DOI 10.1172/JCI32239
   Cohen AD, 2008, DERMATOLOGY, V216, P152, DOI 10.1159/000111512
   Cohen AD, 2007, ACTA DERM-VENEREOL, V87, P506, DOI 10.2340/00015555-0297
   Csiszar A, 2003, FASEB J, V17, P1183, DOI 10.1096/fj.02-1049fje
   Das Swapan Kumar, 2007, Curr Diab Rep, V7, P154, DOI 10.1007/s11892-007-0025-3
   Deanfield JE, 2007, CIRCULATION, V115, P1285, DOI 10.1161/CIRCULATIONAHA.106.652859
   Farshchian M, 2007, J EUR ACAD DERMATOL, V21, P802, DOI 10.1111/j.1468-3083.2006.02099.x
   Gelfand JM, 2007, ARCH DERMATOL, V143, P1493, DOI 10.1001/archderm.143.12.1493
   Gelfand JM, 2006, JAMA-J AM MED ASSOC, V296, P1735, DOI 10.1001/jama.296.14.1735
   Gisondi P, 2007, BRIT J DERMATOL, V157, P68, DOI 10.1111/j.1365-2133.2007.07986.x
   Gonzalez-Juanatey C, 2007, ARTHRIT RHEUM-ARTHR, V57, P287, DOI 10.1002/art.22530
   Griffiths CEM, 2007, LANCET, V370, P263, DOI 10.1016/S0140-6736(07)61128-3
   Grundy SM, 2006, CURR OPIN CARDIOL, V21, P1, DOI 10.1097/01.hco.0000200416.65370.a0
   GUSTAFSON B, 2007, ARTERIOSCLER THROMB, P2276
   Han CL, 2006, J RHEUMATOL, V33, P2167
   Hashmi S, 2006, CORONARY ARTERY DIS, V17, P699, DOI 10.1097/01.mca.0000236288.94553.b4
   Herron MD, 2005, ARCH DERMATOL, V141, P1527, DOI 10.1001/archderm.141.12.1527
   Huerta C, 2007, ARCH DERMATOL, V143, P1559, DOI 10.1001/archderm.143.12.1559
   Kimball AB, 2008, J AM ACAD DERMATOL
   Kurd Shanu Kohli, 2007, Expert Rev Clin Immunol, V3, P171, DOI 10.1586/1744666X.3.2.171
   Lentz SR, 2005, J THROMB HAEMOST, V3, P1646, DOI 10.1111/j.1538-7836.2005.01364.x
   Ludwig RJ, 2007, BRIT J DERMATOL, V156, P271, DOI 10.1111/j.1365-2133.2006.07562.x
   Malerba M, 2006, BRIT J DERMATOL, V155, P1165, DOI 10.1111/j.1365-2133.2006.07503.x
   Mallbris L, 2006, J AM ACAD DERMATOL, V54, P614, DOI 10.1016/j.jaad.2005.11.1079
   Naldi L, 2005, J INVEST DERMATOL, V125, P61, DOI 10.1111/j.0022-202X.2005.23681.x
   Neimann AL., 2006, EXPERT REV DERMATOL, V1, P63, DOI [DOI 10.1586/17469872.1.1.63, 10.1586/17469872.1.1.63]
   Neimann AL, 2006, J AM ACAD DERMATOL, V55, P829, DOI 10.1016/j.jaad.2006.08.040
   Ng MCY, 2005, DIABETOLOGIA, V48, P2018, DOI 10.1007/s00125-005-1914-0
   O'Malley T, 2001, EUR HEART J, V22, P1226, DOI 10.1053/euhj.2000.2480
   Parker A, 2001, DIABETES, V50, P675, DOI 10.2337/diabetes.50.3.675
   RICHARDSON SK, ADV DERMATO IN PRESS
   Romanowska M, 2008, J INVEST DERMATOL, V128, P110, DOI 10.1038/sj.jid.5700943
   Sabat R, 2007, EXP DERMATOL, V16, P779, DOI 10.1111/j.1600-0625.2007.00629.x
   Setty AR, 2007, ARCH INTERN MED, V167, P1670, DOI 10.1001/archinte.167.15.1670
   Shantsila E, 2007, J AM COLL CARDIOL, V49, P741, DOI 10.1016/j.jacc.2006.09.050
   Shapiro J, 2007, J AM ACAD DERMATOL, V56, P629, DOI 10.1016/j.jaad.2006.09.017
   Sommer DM, 2006, ARCH DERMATOL RES, V298, P321, DOI 10.1007/s00403-006-0703-z
   Steinthorsdottir V, 2007, NAT GENET, V39, P770, DOI 10.1038/ng2043
   Sterry W, 2007, BRIT J DERMATOL, V157, P649, DOI 10.1111/j.1365-2133.2007.08068.x
   Suviolahti E, 2006, ANN MED, V38, P337, DOI 10.1080/07853890600865759
   TEKIN NS, 2007, MEDIATORS INFLAM, P1
   Wakkee M, 2007, ATHEROSCLEROSIS, V190, P1, DOI 10.1016/j.atherosclerosis.2006.07.011
   Wei CC, 2006, J BIOMED SCI, V13, P601, DOI 10.1007/s11373-006-9087-5
   Wolf N, 2008, J MED GENET, V45, P114, DOI 10.1136/jmg.2007.053595
   Wozniak A, 2007, MED SCI MONITOR, V13, pCR30
   Yoo H, 2007, INT J BIOCHEM CELL B, V39, P1248, DOI 10.1016/j.biocel.2007.04.009
   Zaina S, 2003, CURR OPIN LIPIDOL, V14, P483, DOI 10.1097/00041433-200310000-00009
NR 52
TC 210
Z9 232
U1 0
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1040-8711
EI 1531-6963
J9 CURR OPIN RHEUMATOL
JI Curr. Opin. Rheumatol.
PD JUL
PY 2008
VL 20
IS 4
BP 416
EP 422
DI 10.1097/BOR.0b013e3283031c99
PG 7
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 322ML
UT WOS:000257379200007
PM 18525354
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hsu, CN
   Hou, CY
   Hsu, WH
   Tain, YL
AF Hsu, Chien-Ning
   Hou, Chih-Yao
   Hsu, Wei-Hsuan
   Tain, You-Lin
TI Early-Life Origins of Metabolic Syndrome: Mechanisms and Preventive
   Aspects
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE cardiovascular disease; obesity; hypertension; oxidative stress;
   metabolic syndrome; dyslipidemia; insulin resistance; diabetes; nutrient
   sensing; developmental origins of health and disease (DOHaD)
ID HIGH-FAT DIET; RENIN-ANGIOTENSIN SYSTEM; INDUCED PROGRAMMED
   HYPERTENSION; IN-UTERO EXPOSURE; LOW-PROTEIN DIET; INCREASES
   BLOOD-PRESSURE; REDUCES NEPHRON NUMBER; HIGH-FRUCTOSE DIET;
   LOW-BIRTH-WEIGHT; DEVELOPMENTAL ORIGINS
AB One of the leading global public-health burdens is metabolic syndrome (MetS), despite the many advances in pharmacotherapies. MetS, now known as "developmental origins of health and disease " (DOHaD), can have its origins in early life. Offspring MetS can be programmed by various adverse early-life conditions, such as nutrition imbalance, maternal conditions or diseases, maternal chemical exposure, and medication use. Conversely, early interventions have shown potential to revoke programming processes to prevent MetS of developmental origins, namely reprogramming. In this review, we summarize what is currently known about adverse environmental insults implicated in MetS of developmental origins, including the fundamental underlying mechanisms. We also describe animal models that have been developed to study the developmental programming of MetS. This review extends previous research reviews by addressing implementation of reprogramming strategies to prevent the programming of MetS. These mechanism-targeted strategies include antioxidants, melatonin, resveratrol, probiotics/prebiotics, and amino acids. Much work remains to be accomplished to determine the insults that could induce MetS, to identify the mechanisms behind MetS programming, and to develop potential reprogramming strategies for clinical translation.
C1 [Hsu, Chien-Ning] Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Med Univ, Sch Pharm, Kaohsiung 807, Taiwan.
   [Hou, Chih-Yao] Natl Kaohsiung Univ Sci & Technol, Dept Seafood Sci, Kaohsiung 811, Taiwan.
   [Hsu, Wei-Hsuan] Natl Chen Kung Univ, Coll Med, Dept Food Safety Hyg & Risk Management, Tainan 701, Taiwan.
   [Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Kaohsiung 833, Taiwan.
   [Tain, You-Lin] Chang Gung Univ, Coll Med, Kaohsiung 833, Taiwan.
   [Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 833, Taiwan.
C3 Chang Gung Memorial Hospital; Kaohsiung Medical University; National
   Kaohsiung University of Science & Technology; National Cheng Kung
   University; Chang Gung Memorial Hospital; Chang Gung University; Chang
   Gung Memorial Hospital
RP Tain, YL (corresponding author), Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Kaohsiung 833, Taiwan.; Tain, YL (corresponding author), Chang Gung Univ, Coll Med, Kaohsiung 833, Taiwan.; Tain, YL (corresponding author), Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 833, Taiwan.
EM cnhsu@cgmh.org.tw; chihyaohou@webmail.nkmu.edu.tw;
   whhsu@mail.ncku.edu.tw; tainyl@cgmh.org.tw
RI HOU, CHIH/S-4983-2018; Tain, You-Lin/H-2827-2019; Hsu,
   Chien-Ning/GLS-4014-2022
OI Hou, Chih-Yao/0000-0002-8007-6077; Hsu, Wei-Hsuan/0000-0002-6598-6435;
   Tain, You-Lin/0000-0002-7059-6407; Hsu, Chien-Ning/0000-0001-7470-528X
FU Ministry of Science and Technology, Taiwan [MOST 110-2314-B182A-029];
   Chang Gung Memorial Hospital, Kaohsiung, Taiwan [CFRPG8H0011,
   CMRPG8J0253, CORPG8J0121, CORPG8L0121, CORPG8L0261, CORPG8L0301]
FX This research was funded by the Ministry of Science and Technology,
   Taiwan, grant MOST 110-2314-B182A-029, and Chang Gung Memorial Hospital,
   Kaohsiung, Taiwan, grants CFRPG8H0011, CMRPG8J0253, CORPG8J0121,
   CORPG8L0121, CORPG8L0261, and CORPG8L0301.
CR Aagaard K, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3008599
   Agus A, 2018, CELL HOST MICROBE, V23, P716, DOI 10.1016/j.chom.2018.05.003
   Al Khodor S, 2017, FRONT PEDIATR, V5, DOI 10.3389/fped.2017.00138
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Andersen LPH, 2016, CLIN DRUG INVEST, V36, P169, DOI 10.1007/s40261-015-0368-5
   Armengaud JB, 2021, REPROD TOXICOL, V99, P168, DOI 10.1016/j.reprotox.2020.10.005
   Armitage JA, 2004, J PHYSIOL-LONDON, V561, P355, DOI 10.1113/jphysiol.2004.072009
   Bergel E, 2002, BJOG-INT J OBSTET GY, V109, P540
   Bessa ASM, 2019, HYPERTENS RES, V42, P1883, DOI 10.1038/s41440-019-0321-8
   Bo S, 2001, EXP CLIN ENDOCR DIAB, V109, P135, DOI 10.1055/s-2001-14835
   Bogdarina I, 2007, CIRC RES, V100, P520, DOI 10.1161/01.RES.0000258855.60637.58
   Boney CM, 2005, PEDIATRICS, V115, pE290, DOI 10.1542/peds.2004-1808
   Bruce KD, 2010, J NUTR, V140, P648, DOI 10.3945/jn.109.111179
   Buettner R, 2007, OBESITY, V15, P798, DOI 10.1038/oby.2007.608
   Buhl ES, 2002, DIABETES, V51, P2199, DOI 10.2337/diabetes.51.7.2199
   Cambonie G, 2007, AM J PHYSIOL-REG I, V292, pR1236, DOI 10.1152/ajpregu.00227.2006
   CAMPBELL AL, 1977, J CLIN ENDOCR METAB, V45, P435, DOI 10.1210/jcem-45-3-435
   Chambers Edward S, 2018, Curr Nutr Rep, V7, P198, DOI 10.1007/s13668-018-0248-8
   Chang HY, 2016, STEROIDS, V108, P1, DOI 10.1016/j.steroids.2016.02.017
   Chao Yung-Mei, 2016, Shengli Xuebao, V68, P557, DOI 10.13294/j.aps.2016.0064
   Chen YC, 2012, J FORMOS MED ASSOC, V111, P57, DOI 10.1016/j.jfma.2011.11.024
   Chen YW, 2010, PEDIATR NEPHROL, V25, P1319, DOI 10.1007/s00467-010-1506-1
   Ching RHH, 2011, J NUTR, V141, P1664, DOI 10.3945/jn.111.142299
   Chong E, 2012, INT J NEPHROL, V2012, DOI 10.1155/2012/760580
   Cottrell EC, 2009, FRONT BEHAV NEUROSCI, V3, DOI 10.3389/neuro.08.019.2009
   Cynober L, 2010, CLIN NUTR, V29, P545, DOI 10.1016/j.clnu.2010.07.006
   de Goffau MC, 2019, NATURE, V572, P329, DOI 10.1038/s41586-019-1451-5
   Correia MLD, 2012, J HUM HYPERTENS, V26, P405, DOI 10.1038/jhh.2011.61
   Guimaraes KSD, 2020, FOOD FUNCT, V11, P8939, DOI [10.1039/d0fo01718c, 10.1039/D0FO01718C]
   de Oliveira Y, 2020, FOOD FUNCT, V11, P5581, DOI [10.1039/d0fo00514b, 10.1039/D0FO00514B]
   Dennery PA, 2010, FREE RADICAL BIO MED, V49, P1147, DOI 10.1016/j.freeradbiomed.2010.07.011
   Dludla PV, 2018, AM J CARDIOVASC DRUG, V18, P283, DOI 10.1007/s40256-018-0275-2
   Dolinsky VW, 2011, DIABETES, V60, P2274, DOI 10.2337/db11-0374
   Eberle C, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0244826
   Efeyan A, 2015, NATURE, V517, P302, DOI 10.1038/nature14190
   Elahi MM, 2013, ANN NUTR METAB, V62, P250, DOI 10.1159/000346037
   Elahi MM, 2008, HYPERTENSION, V51, P939, DOI 10.1161/HYPERTENSIONAHA.107.100982
   Fan EG, 2008, J MED FOOD, V11, P610, DOI 10.1089/jmf.2007.0091
   Ferreira DS, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038795
   Finck BN, 2007, CIRCULATION, V115, P2540, DOI 10.1161/CIRCULATIONAHA.107.670588
   Franco MD, 2009, LIFE SCI, V85, P327, DOI 10.1016/j.lfs.2009.06.013
   Fraser A, 2010, CIRCULATION, V121, P2557, DOI 10.1161/CIRCULATIONAHA.109.906081
   Fujii T, 2011, J DEV ORIG HLTH DIS, V2, P176, DOI 10.1017/S204017441100002X
   Galyon KD, 2017, AM J OBSTET GYNECOL, V216, DOI 10.1016/j.ajog.2016.08.041
   Gatarek P, 2021, EXCLI J, V20, P301, DOI 10.17179/excli2020-3239
   Gluckman PD, 2004, TRENDS ENDOCRIN MET, V15, P183, DOI 10.1016/j.tem.2004.03.002
   Gray SP, 2010, J AM SOC NEPHROL, V21, P1891, DOI 10.1681/ASN.2010040368
   Grigore D, 2007, AM J PHYSIOL-REG I, V293, pR804, DOI 10.1152/ajpregu.00725.2006
   Hanson M, 2015, J DEV ORIG HLTH DIS, V6, P434, DOI 10.1017/S2040174415001129
   Hanson M, 2011, AM J CLIN NUTR, V94, p1754S, DOI 10.3945/ajcn.110.001206
   Hao XQ, 2010, HYPERTENS RES, V33, P76, DOI 10.1038/hr.2009.185
   Holemans K, 1996, J SOC GYNECOL INVEST, V3, P71, DOI 10.1016/1071-5576(95)00046-1
   Holloway AC, 2005, DIABETOLOGIA, V48, P2661, DOI 10.1007/s00125-005-0022-5
   Hrudey EJ, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0133313
   Hsu CN, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.745716
   Hsu CN, 2021, HEALTHCARE-BASEL, V9, DOI 10.3390/healthcare9101332
   Hsu CN, 2021, NUTRIENTS, V13, DOI 10.3390/nu13072290
   Hsu CN, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9060623
   Hsu CN, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22084210
   Hsu CN, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22052674
   Hsu CN, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22052298
   Hsu CN, 2021, MOL NUTR FOOD RES, V65, DOI 10.1002/mnfr.202001116
   Hsu CN, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21228705
   Hsu CN, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9111034
   Hsu CN, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061763
   Hsu CN, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21062232
   Hsu CN, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122908
   Hsu CN, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20225681
   Hsu CN, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20184382
   Hsu CN, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201900073
   Hsu CN, 2018, NUTRIENTS, V10, DOI 10.3390/nu10121917
   Hsu CN, 2018, NUTRIENTS, V10, DOI 10.3390/nu10091229
   Hsu CN, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700596
   Hsu CN, 2016, FRONT PHYSIOL, V7, DOI 10.3389/fphys.2016.00299
   Hsu MH, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21103428
   Huang LT, 2012, INT J MOL SCI, V13, P14606, DOI 10.3390/ijms131114606
   Hult M, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013582
   Ibrahim KG, 2022, PLANTA MED, V88, P650, DOI 10.1055/a-1482-2343
   Iqbal W, 2013, AM J OBSTET GYNECOL, V209, DOI 10.1016/j.ajog.2013.08.027
   Jansson T, 2013, CLIN OBSTET GYNECOL, V56, P591, DOI 10.1097/GRF.0b013e3182993a2e
   Jasarevic E, 2019, FRONT NEUROENDOCRIN, V55, DOI 10.1016/j.yfrne.2019.100797
   Jegatheesan P, 2016, CLIN NUTR, V35, P175, DOI 10.1016/j.clnu.2015.01.021
   Jou MY, 2010, J NUTR, V140, P1621, DOI 10.3945/jn.109.119677
   Kalagiri RR, 2016, AM J PERINAT, V33, P1337, DOI 10.1055/s-0036-1582397
   Kelishadi R, 2015, PAEDIATR INT CHILD H, V35, P110, DOI 10.1179/2046905514Y.0000000136
   Khomami MB, 2019, OBES REV, V20, P659, DOI 10.1111/obr.12829
   Kirkley AG, 2014, CURR DIABETES REP, V14, DOI 10.1007/s11892-014-0494-0
   Koeners MP, 2007, ACTA PHYSIOL, V190, P329, DOI 10.1111/j.1748-1761.2007.01702.x
   Kulkarni SS, 2015, BBA-MOL BASIS DIS, V1852, P1114, DOI 10.1016/j.bbadis.2014.10.005
   Langley-Evans SC, 2000, INT J FOOD SCI NUTR, V51, P11, DOI 10.1080/096374800100859
   Larsen JR, 2018, EXPERT REV CLIN PHAR, V11, P397, DOI 10.1080/17512433.2018.1429910
   Lee WC, 2018, BIOMED J, V41, P96, DOI 10.1016/j.bj.2018.02.006
   Li M, 2020, J DEV ORIG HLTH DIS, V11, P419, DOI 10.1017/S2040174419000709
   Li SY, 2012, J NUTR BIOCHEM, V23, P1655, DOI 10.1016/j.jnutbio.2011.11.008
   Li XY, 2019, BBA-MOL BASIS DIS, V1865, P147, DOI 10.1016/j.bbadis.2018.10.040
   Lian Y, 2019, PSYCHIAT RES, V274, P66, DOI 10.1016/j.psychres.2019.01.096
   Litvinova L, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00020
   Lumey LH, 1998, P NUTR SOC, V57, P129, DOI 10.1079/PNS19980019
   Ma N, 2012, J PREGNANCY, V2012, DOI 10.1155/2012/482690
   Masuyama H, 2016, AM J PHYSIOL-ENDOC M, V311, pE236, DOI 10.1152/ajpendo.00095.2016
   Matumba MG, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020226
   McMillen IC, 2005, PHYSIOL REV, V85, P571, DOI 10.1152/physrev.00053.2003
   McMullen S, 2009, P NUTR SOC, V68, P306, DOI 10.1017/S0029665109001396
   Moisiadis VG, 2014, NAT REV ENDOCRINOL, V10, P391, DOI 10.1038/nrendo.2014.73
   Monsalve FA, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/549627
   Newgard CB, 2009, CELL METAB, V9, P311, DOI 10.1016/j.cmet.2009.02.002
   Nguyen TMT, 2019, J PHYSIOL-LONDON, V597, P5619, DOI 10.1113/JP278531
   Nimse SB, 2015, RSC ADV, V5, P27986, DOI 10.1039/c4ra13315c
   Nuesken KD, 2008, ENDOCRINOLOGY, V149, P1056, DOI 10.1210/en.2007-0891
   Nyakudya TT, 2018, NUTR METAB, V15, DOI 10.1186/s12986-018-0314-7
   Nyirenda MJ, 1998, J CLIN INVEST, V101, P2174, DOI 10.1172/JCI1567
   Okatani Y, 1998, J PINEAL RES, V25, P129, DOI 10.1111/j.1600-079X.1998.tb00550.x
   Olaniyi KS, 2020, FRONT CELL INFECT MI, V10, DOI 10.3389/fcimb.2020.00413
   Oliveira AC, 2015, LIFE SCI, V136, P151, DOI 10.1016/j.lfs.2015.06.024
   Ozanne SE, 1996, AM J PHYSIOL-ENDOC M, V270, pE559, DOI 10.1152/ajpendo.1996.270.4.E559
   Park S, 2020, NUTR RES, V73, P48, DOI 10.1016/j.nutres.2019.09.008
   Paul HA, 2019, FASEB J, V33, P5153, DOI 10.1096/fj.201801551R
   Pisoschi AM, 2015, EUR J MED CHEM, V97, P55, DOI 10.1016/j.ejmech.2015.04.040
   Putnam K, 2012, AM J PHYSIOL-HEART C, V302, pH1219, DOI 10.1152/ajpheart.00796.2011
   Rajagopal G, 2019, J APPL TOXICOL, V39, P751, DOI 10.1002/jat.3764
   Reiter RJ, 2014, HUM REPROD UPDATE, V20, P293, DOI 10.1093/humupd/dmt054
   Rodríguez L, 2015, J NUTR METAB, V2015, DOI 10.1155/2015/158091
   Ros P, 2018, ENDOCRINOLOGY, V159, P810, DOI 10.1210/en.2017-00610
   Roysommuti S, 2009, ADV EXP MED BIOL, V643, P145, DOI 10.1007/978-0-387-75681-3_15
   Saad AF, 2016, AM J OBSTET GYNECOL, V215, DOI 10.1016/j.ajog.2016.03.038
   Sahajpal V, 2005, J PHYSIOL-LONDON, V563, P193, DOI 10.1113/jphysiol.2004.078642
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Saravanan P, 2020, LANCET DIABETES ENDO, V8, P793, DOI 10.1016/S2213-8587(20)30161-3
   Scheer FAJL, 2009, P NATL ACAD SCI USA, V106, P4453, DOI 10.1073/pnas.0808180106
   Schulz LC, 2010, P NATL ACAD SCI USA, V107, P16757, DOI 10.1073/pnas.1012911107
   Sengupta P, 2013, INT J PREVENTIVE MED, V4, P624
   Sferruzzi-Perri AN, 2016, FRONT PHYSIOL, V7, DOI 10.3389/fphys.2016.00033
   Shah A, 2016, J PHYSIOL-LONDON, V594, P1465, DOI 10.1113/JP271133
   Sheen JM, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-24010-0
   Sheen JM, 2015, LIFE SCI, V132, P41, DOI 10.1016/j.lfs.2015.04.005
   Sherman SB, 2018, GUT MICROBES, V9, P400, DOI 10.1080/19490976.2018.1441664
   Simonson M, 2020, REV ENDOCR METAB DIS, V21, P341, DOI 10.1007/s11154-020-09574-5
   Singh AP, 2019, MED RES REV, V39, P1851, DOI 10.1002/med.21565
   Slabiak-Blaz N, 2015, KIDNEY BLOOD PRESS R, V40, P413, DOI 10.1159/000368515
   Slotkin TA, 2004, TOXICOL APPL PHARM, V198, P132, DOI 10.1016/j.taap.2003.06.001
   Smith RL, 2018, ENDOCR REV, V39, P489, DOI 10.1210/er.2017-00211
   Soubry A, 2018, BIOESSAYS, V40, DOI 10.1002/bies.201700113
   Stanner S A, 2001, Twin Res, V4, P287, DOI 10.1375/twin.4.5.287
   Sumová A, 2006, FEBS LETT, V580, P2836, DOI 10.1016/j.febslet.2006.03.023
   Tain YL, 2014, FREE RADICAL RES, V48, P580, DOI 10.3109/10715762.2014.895341
   Tain YL, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19092584
   Tain YL, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201800066
   Tain YL, 2017, BIOL REPROD, V97, P636, DOI 10.1093/biolre/iox115
   Tain YL, 2017, J NUTR BIOCHEM, V48, P120, DOI 10.1016/j.jnutbio.2017.06.007
   Tain YL, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18040841
   Tain YL, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040357
   Tain YL, 2017, TOXINS, V9, DOI 10.3390/toxins9030092
   Tain YL, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18020426
   Tain YL, 2016, AM J OBSTET GYNECOL, V215, DOI 10.1016/j.ajog.2016.07.036
   Tain YL, 2016, NUTRIENTS, V8, DOI 10.3390/nu8120757
   Tain YL, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17010023
   Tain YL, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17010020
   Tain YL, 2015, BIOL REPROD, V92, DOI 10.1095/biolreprod.114.121384
   Tain YL, 2014, J PINEAL RES, V57, P80, DOI 10.1111/jpi.12145
   Tain YL, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/283180
   Tain YL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055420
   Tain YL, 2010, NITRIC OXIDE-BIOL CH, V23, P34, DOI 10.1016/j.niox.2010.03.005
   Takahashi JS, 2017, NAT REV GENET, V18, P164, DOI 10.1038/nrg.2016.150
   Tam WH, 2017, DIABETES CARE, V40, P679, DOI 10.2337/dc16-2397
   Tamburini S, 2016, NAT MED, V22, P713, DOI 10.1038/nm.4142
   Tamura H, 2008, REPROD TOXICOL, V25, P291, DOI 10.1016/j.reprotox.2008.03.005
   Tare M, 2011, J PHYSIOL-LONDON, V589, P4777, DOI 10.1113/jphysiol.2011.214726
   te Riet L, 2015, CIRC RES, V116, P960, DOI 10.1161/CIRCRESAHA.116.303587
   Tenorio-Jiménez C, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010124
   Thaeomor A, 2017, ADV EXP MED BIOL, V975, P295, DOI 10.1007/978-94-024-1079-2_26
   Thompson LP, 2012, J PREGNANCY, V2012, DOI 10.1155/2012/582748
   Diaz-Gerevini GT, 2016, NUTRITION, V32, P174, DOI 10.1016/j.nut.2015.08.017
   Tomat A, 2010, BRIT J NUTR, V104, P382, DOI 10.1017/S0007114510000759
   Tsai CC, 2018, EXP THER MED, V16, P917, DOI 10.3892/etm.2018.6256
   Tsai TA, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17082780
   Tsai WL, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020448
   Tsosura TVS, 2019, INT ENDOD J, V52, P1040, DOI 10.1111/iej.13096
   Vaag A, 2007, CURR OPIN CLIN NUTR, V10, P591, DOI 10.1097/MCO.0b013e3282ab9ea6
   Vega CC, 2016, J PHYSIOL-LONDON, V594, P1483, DOI 10.1113/JP271543
   Walton SL, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-08365-4
   Wang Guoying, 2014, Curr Environ Health Rep, V1, P78
   Wang J, 2016, SCI REP-UK, V6, DOI 10.1038/srep39469
   Wang ZN, 2018, PROTEIN CELL, V9, P416, DOI 10.1007/s13238-018-0549-0
   Wankhade UD, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0175675
   Watkins AJ, 2014, AM J PHYSIOL-HEART C, V306, DOI 10.1152/ajpheart.00981.2013
   Wei ZZ, 2012, TOXICOL LETT, V212, P212, DOI 10.1016/j.toxlet.2012.05.023
   Williams L, 2014, BBA-MOL BASIS DIS, V1842, P507, DOI 10.1016/j.bbadis.2013.07.006
   Wlodek ME, 2008, KIDNEY INT, V74, P187, DOI 10.1038/ki.2008.153
   Wu F, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/293271
   Wu ZH, 2014, EUR J NUTR, V53, P1669, DOI 10.1007/s00394-014-0673-4
   Xiao DL, 2015, BIOL REPROD, V93, DOI 10.1095/biolreprod.115.132381
   Yamada-Obara N, 2016, CLIN EXP NEPHROL, V20, P853, DOI 10.1007/s10157-016-1265-9
   Yang T, 2018, NAT REV NEPHROL, V14, P442, DOI 10.1038/s41581-018-0018-2
   Zarocostas John, 2010, BMJ, V341, pc7065, DOI 10.1136/bmj.c7065
   Zhang HQ, 2014, DIABETOLOGIA, V57, P2165, DOI 10.1007/s00125-014-3316-7
   Zhou LY, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00985
   Zimmet P, 2019, J INTERN MED, V286, P181, DOI 10.1111/joim.12924
   Zou TD, 2017, J PHYSIOL-LONDON, V595, P1547, DOI 10.1113/JP273478
   Zuchowski Y, 2021, PHYSIOL REP, V9, DOI 10.14814/phy2.14941
NR 199
TC 53
Z9 55
U1 2
U2 31
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD NOV
PY 2021
VL 22
IS 21
AR 11872
DI 10.3390/ijms222111872
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA XE3JG
UT WOS:000723287600001
PM 34769303
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jakovljevic, V
   Milic, P
   Bradic, J
   Jeremic, J
   Zivkovic, V
   Srejovic, I
   Turnic, TN
   Milosavljevic, I
   Jeremic, N
   Bolevich, S
   Borovic, ML
   Mitrovic, M
   Vucic, V
AF Jakovljevic, Vladimir
   Milic, Petar
   Bradic, Jovana
   Jeremic, Jovana
   Zivkovic, Vladimir
   Srejovic, Ivan
   Turnic, Tamara Nikolic
   Milosavljevic, Isidora
   Jeremic, Nevena
   Bolevich, Sergey
   Borovic, Milica Labudovic
   Mitrovic, Miroslav
   Vucic, Vesna
TI Standardized Aronia melanocarpa Extract as Novel Supplement
   against Metabolic Syndrome: A Rat Model
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE metabolic syndrome; Aronia melanocarpa; standardized extract; dietary
   strategies; supplementation
ID BLOOD-PRESSURE; ETHANOLIC EXTRACT; FAT; CHOKEBERRY; DIET;
   ECHOCARDIOGRAPHY; INHIBITION; REDUCTION; QUALITY
AB The aim of our study was to examine the effects of different dietary strategies, high-fat (HFd) or standard diet (Sd) alone or in combination with standardized oral supplementation (0.45 mL/kg/day) of Aronia melanocarpa extract (SAE) in rats with metabolic syndrome (MetS). SAE is an official product of pharmaceutical company Pharmanova (Belgrade, Serbia); however, the procedure for extraction was done by EU-Chem company (Belgrade, Serbia). Rats were divided randomly into six groups: control with Sd, control with Sd and SAE, MetS with HFd, MetS with HFd and SAE, MetS with Sd and MetS with Sd and SAE during 4 weeks. At the end of the 4-week protocol, cardiac function and liver morphology were assessed, while in the blood samples glucose, insulin, iron levels and systemic redox state were determined. Our results demonstrated that SAE had the ability to lower blood pressure and exert benefits on in vivo and ex vivo heart function. Moreover, SAE improved glucose tolerance, attenuated pathological liver alterations and oxidative stress present in MetS. Obtained beneficial effects of SAE were more prominent in combination with changing dietary habits. Promising potential of SAE supplementation alone or in combination with different dietary protocols in triggering cardioprotection should be further examined in future.
C1 [Jakovljevic, Vladimir; Zivkovic, Vladimir; Srejovic, Ivan] Univ Kragujevac, Fac Med Sci, Dept Physiol, Svetozara Markovica 69, Kragujevac 34000, Serbia.
   [Jakovljevic, Vladimir; Bolevich, Sergey] Univ IM Sechenov, Moscow State Med 1, Dept Human Pathol, Trubetskaya St 8, Moscow 119991, Russia.
   [Milic, Petar] High Med Sch Profess Studies Cuprija, Dept Pharm, Lole Ribara 1-2, Cuprija 35000, Serbia.
   [Bradic, Jovana; Jeremic, Jovana; Turnic, Tamara Nikolic; Milosavljevic, Isidora; Jeremic, Nevena] Univ Kragujevac, Dept Pharm, Fac Med Sci, Svetozara Markovica 69, Kragujevac 34000, Serbia.
   [Borovic, Milica Labudovic] Univ Belgrade, Inst Histol & Embryol Aleksandar Dj Kostic, Fac Med, Dr Subotic 8, Belgrade 11000, Serbia.
   [Mitrovic, Miroslav] Pharmanova, Gen Anrija 6, Belgrade 11010, Serbia.
   [Vucic, Vesna] Univ Belgrade, Inst Med Res, Ctr Res Excellence Nutr & Metab, Tadeusa Koscuska 1, Belgrade 11129, Serbia.
C3 University of Kragujevac; Sechenov First Moscow State Medical
   University; University of Kragujevac; University of Belgrade; University
   of Belgrade
RP Jakovljevic, V (corresponding author), Univ Kragujevac, Fac Med Sci, Dept Physiol, Svetozara Markovica 69, Kragujevac 34000, Serbia.; Jakovljevic, V (corresponding author), Univ IM Sechenov, Moscow State Med 1, Dept Human Pathol, Trubetskaya St 8, Moscow 119991, Russia.
EM drvladakgbg@yahoo.com; milic.milic@gmail.com; jovanabradickg@gmail.com;
   jovana.jeremic@medf.kg.ac.rs; vladimirziv@gmail.com;
   ivan_srejovic@hotmail.com; tamara.nikolic@medf.kg.ac.rs;
   isidora.stojic@medf.kg.ac.rs; nbarudzic@hotmail.com;
   bolevich2011@yandex.ru; milic.milic@gmail.com;
   miroslav.mitrovic@pharmanova.com; vesna.vucic.imr@gmail.com
RI Bolevich, Sergey/V-1798-2019; Nikolic Turnic, Tamara/AAZ-2847-2020;
   Jeremic, Nevena/U-9443-2019; Zivkovic, Vladimir/U-8941-2019; Srejovic,
   Ivan/L-2468-2019; Jeremic, Jovana/ABH-9087-2020; vucic,
   vesna/AFN-8591-2022; Bradic, Jovana/ABH-9126-2020; Stojic,
   Isidora/AAY-6092-2020; Jakovljevic, Vladimir/V-1583-2019
OI Novakovic, Jovana/0000-0002-8084-3264; Labudovic Borovic,
   Milica/0000-0003-1471-0014; Zivkovic, Vladimir/0000-0001-9354-9876;
   Bradic, Jovana/0000-0001-5388-6085; Srejovic, Ivan/0000-0002-3835-1856;
   Mitrovic, Miroslav/0000-0001-6872-9728; Bolevich,
   Sergey/0000-0002-1574-477X; Nikolic Turnic, Tamara/0000-0002-9105-1350;
   Vucic, Vesna/0000-0002-8563-594X; Stojic, Isidora/0000-0001-9141-4281
CR Auberval N, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-130
   Auclair C., 1985, Handbook of Methods for Oxygen Radical Research
   Bernabe J., 2015, J. Nutr. Disorders Ther, V5, P4
   Beutler E., 1982, Red Cell Metabolism: A manual of Biochemical Methods, P105, DOI DOI 10.1016/J.CHEMOSPHERE.2010.10.011
   Beutler E., 1975, Red Cell Metabolism. A manual of biochemical methods, V2nd
   Bhaswant M, 2017, NUTRITION, V41, P24, DOI 10.1016/j.nut.2016.12.009
   Borowska S, 2016, COMPR REV FOOD SCI F, V15, P982, DOI 10.1111/1541-4337.12221
   Brglez Mojzer Eva, 2016, Molecules, V21, DOI 10.3390/molecules21070901
   Broncel M, 2010, MED SCI MONITOR, V16, pCR28
   Cebova M, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/8156594
   Cherniack EP, 2011, NUTRITION, V27, P617, DOI 10.1016/j.nut.2010.10.013
   Ciocoiu M., 2013, J. Biomed. Sci. Eng, V6, P493
   Daskalova E, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/717439
   de la Iglesia R, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17111877
   Duchnowicz P, 2018, BIOMED RES INT, V2018, DOI 10.1155/2018/5670145
   El-Sayyad S.M., 2016, J. Pharmacogn. Phytochem, V4
   Feng MJ, 2008, AM J HYPERTENS, V21, P1288, DOI 10.1038/ajh.2008.301
   Finelli C, 2013, AGEING RES REV, V12, P996, DOI 10.1016/j.arr.2013.05.007
   GREEN LC, 1982, ANAL BIOCHEM, V126, P131, DOI 10.1016/0003-2697(82)90118-X
   Gregório BM, 2016, CURR PHARM DESIGN, V22, P859, DOI 10.2174/1381612822666151209152352
   Hellström JK, 2010, J FUNCT FOODS, V2, P163, DOI 10.1016/j.jff.2010.04.004
   Imam MU, 2017, NUTRIENTS, V9, DOI 10.3390/nu9070671
   Joffe II, 1999, J AM COLL CARDIOL, V34, P2111, DOI 10.1016/S0735-1097(99)00436-2
   Jurikova T, 2017, MOLECULES, V22, DOI 10.3390/molecules22060944
   Kanthe PS, 2017, J CLIN DIAGN RES, V11, pCC5, DOI 10.7860/JCDR/2017/28474.10628
   Kim NH, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111734
   Kokotkiewicz A, 2010, J MED FOOD, V13, P255, DOI 10.1089/jmf.2009.0062
   Kotronen A, 2007, J CLIN ENDOCR METAB, V92, P3490, DOI 10.1210/jc.2007-0482
   Lee Hye-Ja, 2014, Osong Public Health Res Perspect, V5, P204, DOI 10.1016/j.phrp.2014.06.005
   Leung LN, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/1796357
   Louis XL, 2014, FOOD FUNCT, V5, P1785, DOI [10.1039/c3fo60588d, 10.1039/C3FO60588D]
   Lupascu N., 2016, Eur. J. Interdiscip. Stud, V4, P115, DOI [10.26417/ejis.v4i1.p115-121, DOI 10.26417/EJIS.V4I1.P115-121]
   Mattera R, 2017, NUTRIENTS, V9, DOI 10.3390/nu9050523
   MCCORD JM, 1969, J BIOL CHEM, V244, P6056
   MISRA HP, 1972, J BIOL CHEM, V247, P3170
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   Mu MD, 2016, J NUTR BIOCHEM, V30, P53, DOI 10.1016/j.jnutbio.2015.10.015
   Nammi S, 2009, BASIC CLIN PHARMACOL, V104, P366, DOI 10.1111/j.1742-7843.2008.00362.x
   Naruszewicz M, 2007, ATHEROSCLEROSIS, V194, pE179, DOI 10.1016/j.atherosclerosis.2006.12.032
   Ochmian I, 2012, NOT BOT HORTI AGROBO, V40, P253
   Pari L, 2017, GEN PHYSIOL BIOPHYS, V36, P343, DOI 10.4149/gpb_2016055
   Park CH, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0169685
   Parzonko A, 2016, CURR PHARM DESIGN, V22, P174, DOI 10.2174/1381612822666151112152143
   PICK E, 1980, J IMMUNOL METHODS, V38, P161, DOI 10.1016/0022-1759(80)90340-3
   Ranasinghe P, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4041-1
   Razmaraii N, 2016, ADV PHARM BULL, V6, P423, DOI 10.15171/apb.2016.055
   Simeonov Simeon B, 2002, Folia Med (Plovdiv), V44, P20
   Skarpanska-Stejnborn A, 2014, J INT SOC SPORT NUTR, V11, DOI 10.1186/s12970-014-0048-5
   Tabatabaei-Malazy O, 2015, J DIABETES METAB DIS, V14, DOI 10.1186/s40200-015-0184-8
   Tjelle TE, 2015, BRIT J NUTR, V114, P1054, DOI 10.1017/S0007114515000562
   Tolic MT, 2015, FOOD TECHNOL BIOTECH, V53, P171, DOI 10.17113/ftb.53.02.15.3833
   Wang Y, 2003, ENDOCRINE, V22, P85, DOI 10.1385/ENDO:22:2:85
   Yadegari M., 2015, Malaysian Applied Biology, V44, P85
   Yamane T, 2017, FUNCT FOODS HEALTH D, V7, P280
   Yamane T, 2016, J NUTR BIOCHEM, V31, P106, DOI 10.1016/j.jnutbio.2016.02.004
   Yin Y, 2012, EUR J CLIN INVEST, V42, P1189, DOI 10.1111/j.1365-2362.2012.02706.x
   Zivkovic V, 2012, MOL CELL BIOCHEM, V370, P59, DOI 10.1007/s11010-012-1398-4
NR 57
TC 26
Z9 28
U1 0
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN 1
PY 2019
VL 20
IS 1
AR 6
DI 10.3390/ijms20010006
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HM8RD
UT WOS:000459747700006
PM 30577476
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Yilmaz, H
   Sayar, N
   Yilmaz, M
   Gurkan, U
   Sesal, C
   Tosu, R
   Cakmak, N
   Erer, B
   Oz, D
   Ciloglu, F
   Bolca, O
AF Yilmaz, Hale
   Sayar, Nurten
   Yilmaz, Mehmet
   Gurkan, Ufuk
   Sesal, Cenk
   Tosu, Rodi
   Cakmak, Nazmiye
   Erer, Betul
   Oz, Dilaver
   Ciloglu, Figen
   Bolca, Osman
TI Serum paraoxonase 1 activity in women with metabolic syndrome
SO KARDIOLOGIA POLSKA
LA English
DT Article
DE paraoxonase activity; metabolic syndrome; coronary artery disease
ID CORONARY-ARTERY-DISEASE; LOW-DENSITY-LIPOPROTEIN; HYDROLYTIC ACTIVITY;
   DIABETES-MELLITUS; OXIDATIVE STRESS; PREVALENCE; POLYMORPHISM;
   ASSOCIATION; PHENOTYPE; IMPACT
AB Background: Metabolic syndrome (MetS) is a leading risk factor for coronary artery disease (CAD) in women. Reduced paraoxonase 1 (PON1) activity may play a role in the pathogenesis of atherosclerosis through increased susceptibility to lipid peroxidation in patients with MetS.
   Aim: To examine whether there is a relationship between serum PON1 activity and MetS in women.
   Method: The study group consisted of 54 women with MetS. The NCEP ATP III guidelines were used to define MetS. The control group consisted of 65 women without MetS and CAD. All patients from the MetS group underwent coronary angiography.
   Results: The PON1 activity and salt-stimulated PON1 activity were not significantly altered in women with MetS when compared to controls (p = 0.902, p = 0.877, respectively). There was no significant difference in PON1 activity (p = 0.159), and salt-stimulated PON1 activity (p = 0.139) between diabetics and non-diabetics. In the MetS group, patients with CAD (n = 16) had significantly reduced PON1 activity and salt-stimulated PON1 activity compared to MetS patients without CAD (p = 0.008 and p = 0.004, respectively).
   Conclusions: Serum PON1 activity is significantly reduced in women with CAD and MetS. MetS per se does not alter serum PON1 activities.
C1 [Yilmaz, Hale; Sayar, Nurten; Gurkan, Ufuk; Tosu, Rodi; Cakmak, Nazmiye; Erer, Betul; Oz, Dilaver; Bolca, Osman] Siyami Ersek Thorac & Cardiovasc Surg Ctr, Dept Cardiol, Istanbul, Turkey.
   [Yilmaz, Mehmet] Siyami Ersek Thorac & Cardiovasc Surg Ctr, Dept Cardiovasc Surg, Istanbul, Turkey.
   [Sesal, Cenk] Univ Marmara, Fac Sci & Art, Dept Biol, Istanbul, Turkey.
   [Ciloglu, Figen] Genlab Med Diagnost & Res Lab, Istanbul, Turkey.
C3 Dr. Siyami Ersek Cardiac & Vascular Surgery Training & Research
   Hospital; Dr. Siyami Ersek Cardiac & Vascular Surgery Training &
   Research Hospital; Marmara University; Genlab Group
RP Yilmaz, H (corresponding author), Barbaros Mah Zambak Sokak,Kentplus Sitesi D2 Blok, Istanbul, Turkey.
EM haleyilmaz@tnn.net
RI gürkan, ufuk/GPP-3376-2022; Yilmaz, Hale/AAE-1109-2021; bolca,
   osman/JYP-8138-2024; ozbilgin, nazmiye/MIP-3381-2025; Yilmaz,
   Mehmet/X-6273-2019
OI Yilmaz, Mehmet/0000-0002-6243-6876; YILMAZ, HALE/0000-0002-6365-2423;
   Sesal, Cenk/0000-0002-0737-0122
CR ABBOTT CA, 1995, ARTERIOSCL THROM VAS, V15, P1812, DOI 10.1161/01.ATV.15.11.1812
   [Anonymous], 2009, Diabetes Care, V32, P13
   Ayub A, 1999, ARTERIOSCL THROM VAS, V19, P330, DOI 10.1161/01.ATV.19.2.330
   Çakatay U, 2008, CLIN EXP MED, V8, P51, DOI 10.1007/s10238-008-0156-0
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Gugliucci A, 2007, CLIN CHIM ACTA, V377, P213, DOI 10.1016/j.cca.2006.09.028
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   HEGELE RA, 1995, ARTERIOSCL THROM VAS, V15, P89, DOI 10.1161/01.ATV.15.1.89
   Holvoet P, 2008, Verh K Acad Geneeskd Belg, V70, P193
   KHADER Y, 2008, J CARDIOMETAB SYNDR, V3, P24
   KOBAYASHI K, 1995, ENDOCR J, V42, P461, DOI 10.1507/endocrj.42.461
   Kopprasch S, 2003, J CLIN ENDOCR METAB, V88, P1711, DOI 10.1210/jc.2002-021561
   Kozan O, 2007, EUR J CLIN NUTR, V61, P548, DOI 10.1038/sj.ejcn.1602554
   Lagos KG, 2009, LIPIDS, V44, P9, DOI 10.1007/s11745-008-3251-9
   Lerman A, 2006, J AM COLL CARDIOL, V47, p59S, DOI 10.1016/j.jacc.2004.10.083
   Lopes NH, 2008, CORONARY ARTERY DIS, V19, P383, DOI 10.1097/MCA.0b013e328306aa8a
   LYONS TJ, 1994, DIABETES, V43, P1090, DOI 10.2337/diabetes.43.9.1090
   MACKNESS MI, 1991, ATHEROSCLEROSIS, V86, P193, DOI 10.1016/0021-9150(91)90215-O
   MCELVEEN J, 1986, CLIN CHEM, V32, P671
   Navab M, 2000, J LIPID RES, V41, P1495
   ONAT A, 2002, ARCH TURK SOC CARDIO, V30, P8
   Ozsahin AK, 2004, DIABETES NUTR METAB, V17, P230
   PrimoParmo SL, 1996, GENOMICS, V33, P498, DOI 10.1006/geno.1996.0225
   Sadeghian S, 2007, CORONARY ARTERY DIS, V18, P163, DOI 10.1097/MCA.0b013e328012a94f
   SAHA N, 1991, CLIN GENET, V40, P277
   Sanghera DK, 1997, ARTERIOSCL THROM VAS, V17, P1067, DOI 10.1161/01.ATV.17.6.1067
   SCHWARTZ CJ, 1992, DIABETES CARE, V15, P1156, DOI 10.2337/diacare.15.9.1156
   Sclavo M, 2001, Ital Heart J Suppl, V2, P125
   Singh S, 2007, INDIAN J MED RES, V125, P783
   Sözmen B, 1999, CLIN BIOCHEM, V32, P423, DOI 10.1016/S0009-9120(99)00034-X
   Sygnowska B., 2005, KARDIOL POL, V63, P4
   SZABO I, 1987, CLIN CHEM, V33, P742
   Tabur S, 2010, EUR J ENDOCRINOL, V162, P535, DOI 10.1530/EJE-09-0732
   Yilmaz H, 2010, KARDIOL POL, V68, P1219
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
   Zeller M, 2005, ARCH INTERN MED, V165, P1192, DOI 10.1001/archinte.165.10.1192
   Zielaskowska J., 2006, Adv. Clin. Exp. Medicine, V15, P1073
NR 37
TC 6
Z9 8
U1 0
U2 6
PU POLSKIE TOWARZYSTOWO KARDIOLOGICZNE
PI WARSZAWA
PA UL STAWKI 3 A LOK 1-2, WARSZAWA, POLAND
SN 0022-9032
EI 1897-4279
J9 KARDIOL POL
JI Kardiol. Pol.
PD NOV
PY 2010
VL 68
IS 11
BP 1219
EP 1225
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 721IN
UT WOS:000287346900003
PM 21108196
DA 2025-06-11
ER

PT J
AU Soegaard, EGI
   Kan, Z
   Aass, HCD
   Koirala, R
   Hauff, E
   Thapa, SB
AF Soegaard, Erik Ganesh Iyer
   Kan, Zhanna
   Aass, Hans Christian Dalsbotten
   Koirala, Rishav
   Hauff, Edvard
   Thapa, Suraj Bahadur
TI Abnormal Cytokines in Trauma Patients Explained by Obesity,
   Musculoskeletal Disease, Smoking, and Lung Disease
SO NEUROPSYCHOBIOLOGY
LA English
DT Article
DE Cytokines; Trauma; PTSD; Metabolic syndrome; Body mass index; Low-grade
   inflammation
ID POSTTRAUMATIC-STRESS-DISORDER; COMBAT-RELATED PTSD; METABOLIC SYNDROME;
   INFLAMMATORY MARKERS; CARDIOVASCULAR-DISEASE; ADIPOSE-TISSUE;
   ASSOCIATION; RISK; PREVALENCE; DEPRESSION
AB Introduction: Low-grade inflammation observed through abnormal plasma cytokine levels has been associated with post-traumatic stress disorder (PTSD). It is not clear whether PTSD independently causes the inflammation or if it is mainly through co-occurring somatic factors such as smoking and obesity. We wanted to explore the effects of biopsychosocial factors on cytokine levels in a clinical setting. Methods: The sample consisted of 51 patients with PTSD, 58 trauma patients without PTSD, and 40 matched controls. We selected cytokines and relevant risk factors for systemic inflammation through pairwise correlations. Then, we used linear regression to analyze the individual and combined effects of these on the (Log(10)) cytokines, particularly estimating the effect of PTSD adjusted for other factors. Results: Higher age, female gender, cigarette smoking, presence of lung and musculoskeletal disease, use of antipsychotic medication, and higher BMI were correlated with higher levels of interleukins IL-1RA, IL-2RA, and IL-6. In the adjusted regression analysis, higher BMI was associated with increased IL-1RA (B = 0.06, p < 0.01), IL-2RA (B = 0.01, p < 0.01), and IL-6 (B = 0.01, p = 0.03). Presence of musculoskeletal disease was associated with increased IL-1RA (B = 0.72, p < 0.01) and IL-6 (B = 0.16, p = 0.01), and decreased IL-2RA (B = -0.09, p < 0.01). Cigarette smoking (B = 0.16, p = 0.01) and presence of lung disease (B = 0.14, p = 0.02) were associated with increased IL-6. PTSD diagnosis was associated with decreased IL-2RA (B = -0.06, p = 0.04). Discussion/Conclusion: Altered cytokine levels in distressed trauma-affected individuals are probably mostly through co-occurring risk factors and not PTSD diagnosis. Increased BMI and musculoskeletal (pain) disease may be particularly strong risk factors and should be addressed.
C1 [Soegaard, Erik Ganesh Iyer; Kan, Zhanna; Hauff, Edvard; Thapa, Suraj Bahadur] Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway.
   [Soegaard, Erik Ganesh Iyer; Koirala, Rishav; Hauff, Edvard; Thapa, Suraj Bahadur] Univ Oslo, Inst Clin Med, Div Mental Hlth & Addict, Oslo, Norway.
   [Aass, Hans Christian Dalsbotten] Oslo Univ Hosp, Div Med Biochem, Oslo, Norway.
   [Koirala, Rishav] Brain & Neurosci Ctr, Kathmandu, Nepal.
C3 University of Oslo; University of Oslo; University of Oslo
RP Soegaard, EGI (corresponding author), Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway.; Soegaard, EGI (corresponding author), Univ Oslo, Inst Clin Med, Div Mental Hlth & Addict, Oslo, Norway.
EM erikganesh@hotmail.com
RI Soegaard, Erik/IQT-7355-2023
OI Koirala, Rishav/0000-0002-9721-2952; Soegaard, Erik Ganesh
   Iyer/0000-0003-2380-4995
FU Regional Health Authority of South-Eastern Norway; Oslo University
   Hospital;  [08/00020-2008024]
FX The project received a research grant from the Regional Health Authority
   of South-Eastern Norway in 2008 [No. 08/00020-2008024] and a grant from
   Oslo University Hospital in 2016. The funding did not affect the choice
   of data, analysis, interpretation, or manuscript writing and submission.
CR Adams C, 2020, BRAIN BEHAV IMMUN, V89, P501, DOI 10.1016/j.bbi.2020.08.002
   American Psychiatric Association (APA), 2013, Diagnostic and Statistical Manual of Mental Disorders, V5th ed
   ANDREWS G, 1985, AUST NZ J PSYCHIAT, V19, P138
   Arvidsson E, 2004, DIABETES, V53, P1966, DOI 10.2337/diabetes.53.8.1966
   Babic D, 2007, PSYCHIAT DANUB, V19, P68
   Baker DG, 2012, NEUROPHARMACOLOGY, V62, P663, DOI 10.1016/j.neuropharm.2011.02.027
   BARON RM, 1986, J PERS SOC PSYCHOL, V51, P1173, DOI 10.1037/0022-3514.51.6.1173
   Bartoli F, 2013, METAB SYNDR RELAT D, V11, P301, DOI 10.1089/met.2013.0010
   Battineni G, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22094798
   Bautista LE, 2005, J HUM HYPERTENS, V19, P149, DOI 10.1038/sj.jhh.1001785
   Behrens G, 2014, CAN MED ASSOC J, V186, pE457, DOI 10.1503/cmaj.140025
   Bocsan CI, 2015, BALK MED J, V32, P352, DOI 10.5152/balkanmedj.2015.15884
   BRAMER G R, 1988, World Health Statistics Quarterly, V41, P32
   Brennstuhl MJ, 2015, PERSPECT PSYCHIATR C, V51, P295, DOI 10.1111/ppc.12093
   Brown DW, 2009, AM J PREV MED, V37, P389, DOI 10.1016/j.amepre.2009.06.021
   Canetti D, 2014, J TRAUMA STRESS, V27, P345, DOI 10.1002/jts.21920
   Carpenter LL, 2010, NEUROPSYCHOPHARMACOL, V35, P2617, DOI 10.1038/npp.2010.159
   Damoiseaux J, 2020, CLIN IMMUNOL, V218, DOI 10.1016/j.clim.2020.108515
   Dayer JM, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00293
   De Berardis D, 2010, INT J IMMUNOPATH PH, V23, P417, DOI 10.1177/039463201002300204
   De Hert M, 2018, DIALOGUES CLIN NEURO, V20, P31, DOI 10.31887/DCNS.2018.20.1/mdehert
   de Oliveira JF, 2018, PSYCHIAT RES, V260, P111, DOI 10.1016/j.psychres.2017.11.061
   Dieleman S M, 2017, Tijdschr Psychiatr, V59, P94
   Eldanasory OA, 2020, TRAVEL MED INFECT DI, V37, DOI 10.1016/j.tmaid.2020.101874
   Eskeland S, 2017, ACTA DERM-VENEREOL, V97, P897, DOI 10.2340/00015555-2702
   Farr OM, 2014, METABOLISM, V63, P1463, DOI 10.1016/j.metabol.2014.08.009
   Flegal KM, 2013, JAMA-J AM MED ASSOC, V309, P71, DOI 10.1001/jama.2012.113905
   Forbes MK, 2015, DRUG ALCOHOL DEPEN, V156, P176, DOI 10.1016/j.drugalcdep.2015.09.007
   Furman D, 2019, NAT MED, V25, P1822, DOI 10.1038/s41591-019-0675-0
   Galic S, 2010, MOL CELL ENDOCRINOL, V316, P129, DOI 10.1016/j.mce.2009.08.018
   Gola H, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-40
   Häuser W, 2013, PAIN, V154, P1216, DOI 10.1016/j.pain.2013.03.034
   Hansson GK, 2009, J THROMB HAEMOST, V7, P328, DOI 10.1111/j.1538-7836.2009.03416.x
   Heppner PS, 2012, PSYCHOSOMATICS, V53, P550, DOI 10.1016/j.psym.2012.05.005
   Herhaus B, 2020, TRANSL PSYCHIAT, V10, DOI 10.1038/s41398-020-0729-6
   Holman EA, 2014, PSYCHOSOM MED, V76, P20, DOI 10.1097/PSY.0000000000000025
   Hussein S, 2017, PSYCHIAT DANUB, V29, P407, DOI 10.24869/psyd.2017.407
   IBM Corp, 2020, IBM SPSS Statistics for Mac (Version 26.0) [Computer software]
   Imai R, 2018, J PSYCHIATR RES, V102, P192, DOI 10.1016/j.jpsychires.2018.04.009
   Jakovljevic M, 2008, PSYCHIAT DANUB, V20, P406
   Jakovljevic Miro, 2006, Psychiatr Danub, V18, P169
   Jin H, 2009, J CLIN PSYCHOPHARM, V29, P210, DOI 10.1097/JCP.0b013e3181a45ed0
   Katrinli S, 2020, NEUROPSYCHOPHARMACOL, V45, P1609, DOI 10.1038/s41386-020-0700-5
   Kibler JL, 2014, WORLD J CARDIOL, V6, P455, DOI 10.4330/wjc.v6.i6.455
   Kibler JL, 2009, J TRAUMA DISSOCIATIO, V10, P135, DOI 10.1080/15299730802624577
   Kim YK, 2016, PROG NEURO-PSYCHOPH, V64, P277, DOI 10.1016/j.pnpbp.2015.06.008
   Klein SL, 2016, NAT REV IMMUNOL, V16, P626, DOI 10.1038/nri.2016.90
   Koenen KC, 2017, PSYCHOL MED, V47, P209, DOI [10.1017/s0033291716002294, 10.1017/S0033291716002294]
   Küffer A, 2019, PSYCHONEUROENDOCRINO, V102, P114, DOI 10.1016/j.psyneuen.2018.12.002
   Lekkas D, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-89768-2
   Levine AB, 2014, CARDIOLOGY, V127, P1, DOI 10.1159/000354910
   Lindqvist D, 2017, BRAIN BEHAV IMMUN, V59, P260, DOI 10.1016/j.bbi.2016.09.012
   Lindqvist D, 2014, BRAIN BEHAV IMMUN, V42, P81, DOI 10.1016/j.bbi.2014.06.003
   Lohr JB, 2015, AM J GERIAT PSYCHIAT, V23, P709, DOI 10.1016/j.jagp.2015.04.001
   Mantovani A, 2019, IMMUNITY, V50, P778, DOI 10.1016/j.immuni.2019.03.012
   Matthews AM, 2011, CNS DRUGS, V25, P299, DOI 10.2165/11588170-000000000-00000
   McFarlane AC, 2017, CURR PSYCHIAT REP, V19, DOI 10.1007/s11920-017-0761-2
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Moradi Yousef, 2021, Clin Diabetes Endocrinol, V7, P4, DOI 10.1186/s40842-021-00117-8
   Najafi A, 2022, LIFE-BASEL, V12, DOI 10.3390/life12050738
   Nilsonne G, 2016, LANCET PSYCHIAT, V3, P200, DOI 10.1016/S2215-0366(16)00022-5
   O'Donovan A, 2016, EVID-BASED MENT HEAL, V19, P120, DOI 10.1136/eb-2016-102376
   Osborn O, 2008, SWISS MED WKLY, V138, P665, DOI /aop/smw-aop12276
   Pan XF, 2018, FRONT MOL NEUROSCI, V11, DOI 10.3389/fnmol.2018.00450
   Pan XF, 2018, BMC PSYCHIATRY, V18, DOI 10.1186/s12888-018-1910-9
   Passos IC, 2015, LANCET PSYCHIAT, V2, P1002, DOI 10.1016/S2215-0366(15)00309-0
   de Heredia FP, 2012, P NUTR SOC, V71, P332, DOI 10.1017/S0029665112000092
   Pérez-Pérez A, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21165887
   Plantinga L, 2013, BRAIN BEHAV IMMUN, V30, P125, DOI 10.1016/j.bbi.2013.01.081
   Pruett S, 2008, EFFECTS DRUGS ABUSE, P133
   Rea IM, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.00586
   Reed R.G., 2016, ENV INFLUENCES IMMUN, P97, DOI [10.1007/978-3-7091-1890-0_5, DOI 10.1007/978-3-7091-1890-0_5]
   Roberts AL, 2015, JAMA PSYCHIAT, V72, P203, DOI 10.1001/jamapsychiatry.2014.2632
   Rodevand L, 2021, TRANSL PSYCHIAT, V11, DOI 10.1038/s41398-020-01142-4
   Rose-John S, 2017, NAT REV RHEUMATOL, V13, P399, DOI 10.1038/nrrheum.2017.83
   Rosenbaum S, 2015, METABOLISM, V64, P926, DOI [10.1016/j.metabol.2015.04.009, 10.1016/j.metabol.2015.01.016]
   Roy SS, 2015, AM J PUBLIC HEALTH, V105, P757, DOI 10.2105/AJPH.2014.302342
   Sadeh N, 2016, MOL PSYCHIATR, V21, P357, DOI 10.1038/mp.2015.134
   Scott KM, 2008, INT J OBESITY, V32, P192, DOI 10.1038/sj.ijo.0803701
   Azcurra DS, 2010, REV PSIQUIATR SALUD, V3, P128, DOI 10.1016/j.rpsm.2010.09.004
   Singh P, 2012, CIRC RES, V111, P599, DOI [10.1161/circresaha.112.273656, 10.1161/CIRCRESAHA.112.273656]
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Solomon Z, 2014, J BEHAV MED, V37, P849, DOI 10.1007/s10865-013-9544-3
   Sullivan Gail M, 2012, J Grad Med Educ, V4, P279, DOI 10.4300/JGME-D-12-00156.1
   Sumner JA, 2020, BIOL PSYCHIAT, V87, P885, DOI 10.1016/j.biopsych.2019.11.005
   Sumner JA, 2015, CIRCULATION, V132, P251, DOI 10.1161/CIRCULATIONAHA.114.014492
   Ting EYC, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21062194
   Toft H, 2021, ACTA NEUROPSYCHIATR, V33, P254, DOI 10.1017/neu.2021.11
   Toft H, 2018, NEUROPSYCH DIS TREAT, V14, P2367, DOI 10.2147/NDT.S173659
   Tsalamandris S, 2019, EUR CARDIOL REV, V14, P50, DOI 10.15420/ecr.2018.33.1
   van den Berk-Clark C, 2018, HEALTH PSYCHOL, V37, P407, DOI 10.1037/hea0000593
   Vena GA, 2008, CURR PHARM DESIGN, V14, P2902, DOI 10.2174/138161208786369777
   Vogelzangs N, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.27
   von Känel R, 2007, J PSYCHIATR RES, V41, P744, DOI 10.1016/j.jpsychires.2006.06.009
   Waheed A, 2018, J INTERF CYTOK RES, V38, P1, DOI 10.1089/jir.2017.0088
   Weiss T, 2011, GEN HOSP PSYCHIAT, V33, P135, DOI 10.1016/j.genhosppsych.2011.01.002
   Wittcopp C, 2016, PEDIATR REV, V37, P193, DOI [10.1542/pir.2014-0095, 10.1159/000449268]
   Wolf EJ, 2016, PSYCHOL MED, V46, P2215, DOI 10.1017/S0033291716000817
   Wolf EJ, 2017, BRAIN BEHAV IMMUN, V65, P328, DOI 10.1016/j.bbi.2017.06.001
   Yang JJ, 2020, J AFFECT DISORDERS, V268, P39, DOI 10.1016/j.jad.2020.02.044
NR 100
TC 0
Z9 0
U1 0
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0302-282X
EI 1423-0224
J9 NEUROPSYCHOBIOLOGY
JI Neuropsychobiology
PD DEC
PY 2022
VL 81
IS 6
BP 516
EP 530
DI 10.1159/000526806
EA OCT 2022
PG 15
WC Neurosciences; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry; Psychology
GA 6Y7JK
UT WOS:000879415600001
PM 36302340
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Wu, JP
   Jia, WH
   Min, DY
   Yang, GL
AF Wu, Junpeng
   Jia, Wenhan
   Min, Dongyu
   Yang, Guanlin
TI Cinnamon for Metabolic Diseases and Their Cardiovascular and Hepatic
   Complications: A Mechanistic Review
SO AMERICAN JOURNAL OF CHINESE MEDICINE
LA English
DT Article
DE Cinnamon; Metabolic Syndrome; Complications; Cinnamaldehyde; Fatty
   Liver; Cardiovascular; Blood Pressure
ID DIET-INDUCED OBESITY; HIGH-FAT DIET; BLOOD-PRESSURE; ADIPOSE-TISSUE;
   DIABETIC MICE; CINNAMALDEHYDE; METAANALYSIS; SUPPLEMENTATION; EXTRACT;
   KINASE
AB Cinnamon is one of the world's oldest and most popular spices, and is derived from the inner bark of several tree species from the genus Cinnamomum. During the last two decades, cinnamon has demonstrated beneficial metabolic effects not only in animal experiments but also in clinical trials. Even recent meta-analyses have shown the protective effects of cinnamon on different components of metabolic syndrome and their complications. In the last 5 years, several experimental studies have unraveled the intricate molecular mechanisms underlying the antihypertensive, antihyperglycemic, lipid-lowering, weight-lowering, and cardioprotective properties of cinnamon. This review paper will discuss how cinnamon and its active components, particularly cinnamaldehyde, suppress inflammation and oxidative stress, modulate mitochondrial dysfunction, and regulate glucose uptake, insulin resistance, lipogenesis, beta-oxidation, Ca2+ signaling, and other cellar events at the molecular level. Specifically, we will delve into the molecular mechanisms involved in the metabolic effects of cinnamon to provide a deeper insight into how cinnamon can bring such beneficial effects. This review hopes to encourage the use of cinnamon in clinical settings, guide the combination of cinnamon with other drugs used to treat different components of metabolic syndrome based on their mechanism of action, and support the concept of complementary medicine for metabolic diseases.
C1 [Wu, Junpeng; Yang, Guanlin] Liaoning Univ Tradit Chinese Med, Clin Coll 1, 79 Chongshan East Rd, Shenyang 110000, Liaoning, Peoples R China.
   [Wu, Junpeng; Yang, Guanlin] Liaoning Univ Tradit Chinese Med, Key Lab, Minist Educ Tradit Chinese Med Viscera State Theor, 79 Chongshan East Rd, Shenyang 110000, Liaoning, Peoples R China.
   [Jia, Wenhan] Liaoning Univ Tradit Chinese Med, P, R China, Shenyang 110000, Liaoning, Peoples R China.
   [Min, Dongyu] Liaoning Univ Tradit Chinese Med, Affiliated Hosp, 33 Beiling St, Shenyang 110000, Liaoning, Peoples R China.
C3 Liaoning University of Traditional Chinese Medicine; Liaoning University
   of Traditional Chinese Medicine; Liaoning University of Traditional
   Chinese Medicine; Liaoning University of Traditional Chinese Medicine
RP Yang, GL (corresponding author), Liaoning Univ Tradit Chinese Med, Clin Coll 1, 79 Chongshan East Rd, Shenyang 110000, Liaoning, Peoples R China.; Yang, GL (corresponding author), Liaoning Univ Tradit Chinese Med, Key Lab, Minist Educ Tradit Chinese Med Viscera State Theor, 79 Chongshan East Rd, Shenyang 110000, Liaoning, Peoples R China.; Min, DY (corresponding author), Liaoning Univ Tradit Chinese Med, Affiliated Hosp, 33 Beiling St, Shenyang 110000, Liaoning, Peoples R China.
EM mindongyu@163.com; guanli19621010@163.com
RI wu, junpeng/MBG-9584-2025
OI wu, junpeng/0009-0004-9242-6283; dongyu, min/0000-0001-6646-9555; JIA,
   wenhan/0009-0008-7412-9188
FU National Natural Science Fund [82374423]
FX This study was financially supported by the National Natural Science
   Fund (82374423).
CR Abdelrahman IA, 2023, SAUDI PHARM J, V31, DOI 10.1016/j.jsps.2023.101737
   Alvarez-Collazo J, 2014, PFLUG ARCH EUR J PHY, V466, P2089, DOI 10.1007/s00424-014-1472-8
   Moraes FDA, 2020, PHARMANUTRITION, V13, DOI 10.1016/j.phanu.2020.100205
   Atasoy S, 2024, J HYPERTENS, V42, P521, DOI 10.1097/HJH.0000000000003629
   Azimian L, 2023, CELL BIOCHEM FUNCT, V41, P254, DOI 10.1002/cbf.3778
   Bhatti Jasvinder Singh, 2017, Biochim Biophys Acta Mol Basis Dis, V1863, P1066, DOI 10.1016/j.bbadis.2016.11.010
   Brandt C, 2016, BIOCHEM J, V473, P3621, DOI 10.1042/BCJ20160418
   Cantó C, 2009, CURR OPIN LIPIDOL, V20, P98, DOI 10.1097/MOL.0b013e328328d0a4
   Chan KE, 2022, J CLIN ENDOCR METAB, V107, P2691, DOI 10.1210/clinem/dgac321
   Chen P, 2022, J CELL MOL MED, V26, P913, DOI 10.1111/jcmm.17148
   Chistiakov DA, 2017, J MOL MED, V95, P1153, DOI 10.1007/s00109-017-1575-8
   Couturier K, 2011, METABOLISM, V60, P1590, DOI 10.1016/j.metabol.2011.03.016
   Davari M, 2020, NUTR J, V19, DOI 10.1186/s12937-019-0518-3
   Dejban P, 2021, PHYTOTHER RES, V35, P835, DOI 10.1002/ptr.6866
   Farazandeh M, 2022, J FOOD BIOCHEM, V46, DOI 10.1111/jfbc.14206
   Guembe MJ, 2020, CARDIOVASC DIABETOL, V19, DOI 10.1186/s12933-020-01166-6
   Guru B, 2022, EUR J PHARMACOL, V935, DOI 10.1016/j.ejphar.2022.175322
   Hadi A, 2020, CLIN NUTR ESPEN, V36, P10, DOI 10.1016/j.clnesp.2020.01.002
   Hanipah ZN, 2020, ANNU REV MED, V71, P1, DOI 10.1146/annurev-med-053117-123246
   Hlebowicz J, 2009, AM J CLIN NUTR, V89, P815, DOI 10.3945/ajcn.2008.26807
   Hoi JK, 2019, J AGR FOOD CHEM, V67, P11638, DOI 10.1021/acs.jafc.9b04274
   Horton JD, 2002, J CLIN INVEST, V109, P1125, DOI 10.1172/JCI200215593
   Huang JQ, 2007, THROMB RES, V119, P337, DOI 10.1016/j.thromres.2006.03.001
   Huang XJ, 2018, INT J BIOL SCI, V14, P1483, DOI 10.7150/ijbs.27173
   Jamali N, 2020, DIABETES METAB SYND, V14, P119, DOI 10.1016/j.dsx.2020.01.009
   Kang YH, 2011, AM J CHINESE MED, V39, P867, DOI 10.1142/S0192415X11009263
   Kaur Navrinder, 2019, Artif Cells Nanomed Biotechnol, V47, P2930, DOI 10.1080/21691401.2019.1641509
   Kim SY, 2010, J MED FOOD, V13, P1069, DOI 10.1089/jmf.2009.1365
   Kumar CU, 2022, J DIABETES METAB DIS, V21, P141, DOI 10.1007/s40200-021-00948-3
   Kutbi EH, 2022, CRIT REV FOOD SCI, V62, P6113, DOI 10.1080/10408398.2021.1896473
   Kwon H, 2015, AM J CHINESE MED, V43, P621, DOI 10.1142/S0192415X1550038X
   Larsen JR, 2018, EXPERT REV CLIN PHAR, V11, P397, DOI 10.1080/17512433.2018.1429910
   Lee SG, 2016, FOODS, V5, DOI 10.3390/foods5040083
   Li BC, 2022, J FOOD BIOCHEM, V46, DOI 10.1111/jfbc.14077
   Li R, 2013, FOOD CHEM TOXICOL, V51, P419, DOI 10.1016/j.fct.2012.10.024
   Li WL, 2023, FRONT PHARMACOL, V14, DOI 10.3389/fphar.2023.1111860
   Li WY, 2023, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.1029736
   Liang XP, 2023, POSTGRAD MED J, V99, P985, DOI 10.1093/postmj/qgad008
   Liu YY, 2023, FOODS, V12, DOI 10.3390/foods12203852
   Liu YY, 2023, FOOD BIOSCI, V52, DOI 10.1016/j.fbio.2023.102405
   Long M, 2015, CANCER PREV RES, V8, P444, DOI 10.1158/1940-6207.CAPR-14-0359
   Lopes BP, 2015, FOOD FUNCT, V6, P3257, DOI [10.1039/c5fo00569h, 10.1039/C5FO00569H]
   Luan F, 2022, CHEM-BIOL INTERACT, V368, DOI 10.1016/j.cbi.2022.110245
   Mohammadi K., 2023, GEN CELL TIS, V10, pe122955
   Moridpour AH, 2024, PHYTOTHER RES, V38, P117, DOI 10.1002/ptr.8026
   Mu YM, 2024, LANCET DIABETES ENDO, V12, P184, DOI 10.1016/S2213-8587(23)00388-1
   Mukherjee S, 2022, LIFE SCI, V288, DOI 10.1016/j.lfs.2021.120204
   Nair A, 2022, J BIOCHEM MOL TOXIC, V36, DOI 10.1002/jbt.23215
   Nayak IMN, 2017, J CLIN DIAGN RES, V11, DOI 10.7860/JCDR/2017/23910.9864
   Nishikai-Shen T, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-13421-9
   Oh J, 2023, NUTRIENTS, V15, DOI 10.3390/nu15245110
   Neto JGO, 2022, FOOD FUNCT, V13, P3405, DOI [10.1039/d1fo03871k, 10.1039/D1FO03871K]
   Neto JGO, 2020, J NUTR BIOCHEM, V77, DOI 10.1016/j.jnutbio.2019.108321
   Ose R, 2020, CLIN EXP ALLERGY, V50, P41, DOI 10.1111/cea.13507
   Peixoto-Neves D, 2014, J CARDIOVASC PHARM, V64, P401, DOI 10.1097/FJC.0000000000000131
   Podeanu MA, 2023, BIOMEDICINES, V11, DOI 10.3390/biomedicines11112961
   Qian DD, 2022, BMC COMPLEMENT MED, V22, DOI 10.1186/s12906-022-03594-1
   Qin B, 2010, HORM METAB RES, V42, P187, DOI 10.1055/s-0029-1242746
   Rad M.K., 2021, KOOMESH, V23, P139
   Rad MK, 2022, ADV TRADIT MED, V22, P271, DOI 10.1007/s13596-020-00537-4
   Rakshe PS, 2024, AGEING RES REV, V96, DOI 10.1016/j.arr.2024.102255
   RAO PV, 2014, EVID-BASED COMPL ALT, V2014, DOI DOI 10.1155/2014/642942
   Salvatore T, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.695792
   Sarmadi B, 2023, NUTR METAB CARDIOVAS, V33, P1821, DOI 10.1016/j.numecd.2023.03.010
   Sawma T, 2022, ATHEROSCLEROSIS, V358, P12, DOI 10.1016/j.atherosclerosis.2022.08.012
   Schink A, 2018, FOOD FUNCT, V9, P5950, DOI [10.1039/C8FO01286E, 10.1039/c8fo01286e]
   Serviddio G, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024084
   Sheng XY, 2008, PPAR RES, V2008, DOI 10.1155/2008/581348
   Song MY, 2017, AM J CHINESE MED, V45, P1017, DOI [10.1142/S0192415X17500549, 10.1142/s0192415x17500549]
   Stanciu S, 2023, METABOLITES, V13, DOI 10.3390/metabo13010087
   Su Q, 2024, CELLS-BASEL, V13, DOI 10.3390/cells13060555
   Su XZ, 2024, ANGEW CHEM INT EDIT, V63, DOI 10.1002/anie.202313859
   Tayebi SM, 2024, HELIYON, V10, DOI 10.1016/j.heliyon.2024.e29742
   Tuzcu Z, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/1583098
   Vallianou N, 2019, COMPLEMENT THER MED, V42, P271, DOI 10.1016/j.ctim.2018.12.005
   Vallion R, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11030575
   Van Liefferinge E, 2021, ANIMALS-BASEL, V11, DOI 10.3390/ani11082262
   Varounis C, 2016, CURR MED RES OPIN, V32, P1175, DOI 10.1185/03007995.2016.1163257
   Vijayakumar K, 2023, ARCH PHYSIOL BIOCHEM, V129, P338, DOI 10.1080/13813455.2020.1822415
   Wang PJ, 2020, AM J HYPERTENS, V33, P610, DOI 10.1093/ajh/hpaa024
   WIJESEKERA ROB, 1978, CRC CR REV FOOD SCI, V10, P1
   Wondrak GT, 2010, MOLECULES, V15, P3338, DOI 10.3390/molecules15053338
   Xue QP, 2022, NUTR METAB, V19, DOI 10.1186/s12986-021-00632-6
   Xue YL, 2011, VASC HEALTH RISK MAN, V7, P273, DOI 10.2147/VHRM.S15429
   Yanai H, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms242015473
   Yang L, 2015, INT J CLIN EXP PATHO, V8, P14345
   Yazdanpanah Z, 2023, J HERB MED, V39, DOI 10.1016/j.hermed.2023.100655
   Yazdanpanah Z, 2020, PHYTOTHER RES, V34, P448, DOI 10.1002/ptr.6539
   Yu TQ, 2023, NUTRIENTS, V15, DOI 10.3390/nu15132983
   Zhang ZY, 2024, BIOMED PHARMACOTHER, V173, DOI 10.1016/j.biopha.2024.116413
   Zhu CY, 2020, COMPLEMENT THER MED, V53, DOI 10.1016/j.ctim.2020.102517
   Zuo JC, 2017, CELL PHYSIOL BIOCHEM, V42, P1514, DOI 10.1159/000479268
NR 92
TC 0
Z9 0
U1 8
U2 8
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0192-415X
EI 1793-6853
J9 AM J CHINESE MED
JI Am. J. Chin. Med.
PY 2024
VL 52
IS 08
BP 2403
EP 2421
DI 10.1142/S0192415X24500915
EA DEC 2024
PG 19
WC Integrative & Complementary Medicine; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; General & Internal Medicine
GA R2F8O
UT WOS:001380219300001
PM 39702975
DA 2025-06-11
ER

PT J
AU Nouri, Z
   Hajialyani, M
   Izadi, Z
   Bahramsoltani, R
   Farzaei, MH
   Abdollahi, M
AF Nouri, Zeinab
   Hajialyani, Marziyeh
   Izadi, Zhila
   Bahramsoltani, Roodabeh
   Farzaei, Mohammad Hosein
   Abdollahi, Mohammad
TI Nanophytomedicines for the Prevention of Metabolic Syndrome: A
   Pharmacological and Biopharmaceutical Review
SO FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
LA English
DT Review
DE medicinal plants; nanoparticles; diabetes; metabolic syndrome;
   nanophytomedicines; phytotherapy
ID SOLID LIPID NANOPARTICLES; SYNTHESIZED GOLD NANOPARTICLES; CONJUGATED
   LINOLENIC ACID; TYPE-2 DIABETES-MELLITUS; NF-KAPPA-B; SILVER
   NANOPARTICLES; IN-VITRO; INSULIN-RESISTANCE; ZNO NANOPARTICLES;
   OXIDATIVE STRESS
AB Metabolic syndrome includes a series of metabolic abnormalities that leads to diabetes mellitus and cardiovascular diseases. Plant extracts, due to their unique advantages like anti-inflammatory, antioxidant, and insulin sensitizing properties, are interesting therapeutic options to manage MetS; however, the poor solubility and low bioavailability of lipophilic bioactive components in the herbal extracts are two critical challenges. Nano-scale delivery systems are suitable to improve delivery of herbal extracts. This review, for the first time, focuses on nanoformulations of herbal extracts in MetS and related complications. Included studies showed that several forms of nano drug delivery systems such as nanoemulsions, solid lipid nanoparticles, nanobiocomposites, and green-synthesized silver, gold, and zinc oxide nanoparticles have been developed using herbal extracts. It was shown that the method of preparation and related parameters such as temperature and type of polymer are important factors affecting physicochemical stability and therapeutic activity of the final product. Many of these formulations could successfully decrease the lipid profile, inflammation, oxidative damage, and insulin resistance in in vitro and in vivo models of MetS-related complications. Further studies are still needed to confirm the safety and efficacy of these novel herbal formulations for clinical application.
C1 [Nouri, Zeinab] Kermanshah Univ Med Sci, Students Res Comm, Fac Pharm, Kermanshah, Iran.
   [Hajialyani, Marziyeh; Izadi, Zhila; Farzaei, Mohammad Hosein] Kermanshah Univ Med Sci, Hlth Inst, Pharmaceut Sci Res Ctr, Kermanshah, Iran.
   [Bahramsoltani, Roodabeh] Univ Tehran Med Sci, Sch Persian Med, Dept Tradit Pharm, Tehran, Iran.
   [Bahramsoltani, Roodabeh] Univ Sci Educ & Res Network, PhytoPharmacol Interest Grp, Tehran, Iran.
   [Farzaei, Mohammad Hosein] Kermanshah Univ Med Sci, Med Biol Res Ctr, Kermanshah, Iran.
   [Abdollahi, Mohammad] Univ Tehran Med Sci, Inst Pharmaceut Sci, Toxicol & Dis Grp, Pharmaceut Sci Res Ctr, Tehran, Iran.
   [Abdollahi, Mohammad] Univ Tehran Med Sci, Sch Pharm, Dept Pharmacol & Toxicol, Tehran, Iran.
C3 Kermanshah University of Medical Sciences; Kermanshah University of
   Medical Sciences; Tehran University of Medical Sciences; Kermanshah
   University of Medical Sciences; Tehran University of Medical Sciences;
   Tehran University of Medical Sciences
RP Farzaei, MH (corresponding author), Kermanshah Univ Med Sci, Hlth Inst, Pharmaceut Sci Res Ctr, Kermanshah, Iran.; Farzaei, MH (corresponding author), Kermanshah Univ Med Sci, Med Biol Res Ctr, Kermanshah, Iran.; Abdollahi, M (corresponding author), Univ Tehran Med Sci, Inst Pharmaceut Sci, Toxicol & Dis Grp, Pharmaceut Sci Res Ctr, Tehran, Iran.; Abdollahi, M (corresponding author), Univ Tehran Med Sci, Sch Pharm, Dept Pharmacol & Toxicol, Tehran, Iran.
EM mh.farzaei@gmail.com; Mohammad@TUMS.Ac.Ir
RI Izadi, Zhila/AGU-5007-2022; Farzaei, Mohammad/M-5779-2017;
   Bahramsoltani, Roodabeh/A-1001-2018; /B-9232-2008
OI Bahramsoltani, Roodabeh/0000-0001-6942-0546; /0000-0003-0123-1209
CR Agnihotri A, 2013, ACTA POL PHARM, V70, P1011
   Ahmad U, 2018, BMC COMPLEM ALTERN M, V18, DOI 10.1186/s12906-018-2245-2
   Ajiboye BO, 2018, J EVID-BASED INTEGR, V23, DOI 10.1177/2515690X18770630
   Al-Taweel AM, 2012, FITOTERAPIA, V83, P1610, DOI 10.1016/j.fitote.2012.09.010
   Alamoudi E.F., 2014, Int. J. Pharmaceut. Sci. Rev. Res., V29, P279
   Aldawsari HM, 2014, Z NATURFORSCH C, V69, P391, DOI 10.5560/ZNC.2014-0047
   Ali HA, 2014, SAUDI MED J, V35, P1501
   Alkaladi A, 2014, INT J MOL SCI, V15, P2015, DOI 10.3390/ijms15022015
   Ames-Sibin AP, 2018, J CELL BIOCHEM, V119, P10262, DOI 10.1002/jcb.27369
   Anandharajan R, 2006, PHYTOMEDICINE, V13, P434, DOI 10.1016/j.phymed.2005.03.008
   Anbazhagan P, 2017, J CLUST SCI, V28, P91, DOI 10.1007/s10876-016-1047-2
   Anderson JW, 2007, METABOLISM, V56, P280, DOI 10.1016/j.metabol.2006.10.013
   [Anonymous], 2016, J BIOL MACROMOL
   Ansari S, 2019, J PHOTOCH PHOTOBIO B, V201, DOI [10.1016/j.photobiol.2019.111643, 10.1016/j.jphotobiol.2019.111643]
   Aris FAF, 2019, BIOCATAL AGR BIOTECH, V21, DOI 10.1016/j.bcab.2019.101332
   Arvanag FM, 2019, MAT SCI ENG C-MATER, V97, P397, DOI 10.1016/j.msec.2018.12.058
   Aswathanarayan JB, 2019, FRONT SUSTAIN FOOD S, V3, DOI 10.3389/fsufs.2019.00095
   Atale N, 2017, APPL BIOCHEM BIOTECH, V181, P1140, DOI 10.1007/s12010-016-2274-6
   Badescu M, 2015, PHARM BIOL, V53, P533, DOI 10.3109/13880209.2014.931441
   Baker RG, 2011, CELL METAB, V13, P11, DOI 10.1016/j.cmet.2010.12.008
   Bala N, 2015, RSC ADV, V5, P4993, DOI 10.1039/c4ra12784f
   Barwal I, 2013, COLLOID SURFACE B, V101, P510, DOI 10.1016/j.colsurfb.2012.07.005
   Baskar V., 2012, Asian J Pharm Clin Res, V5, P241
   Bayrami A, 2019, ULTRASON SONOCHEM, V58, DOI 10.1016/j.ultsonch.2019.104613
   Bayrami A, 2018, ARTIF CELL NANOMED B, V46, P730, DOI 10.1080/21691401.2017.1337025
   Becic Tarik, 2018, Med Sci (Basel), V6, DOI 10.3390/medsci6040097
   Beltrán-Sánchez H, 2013, J AM COLL CARDIOL, V62, P697, DOI 10.1016/j.jacc.2013.05.064
   Bergman RN, 2001, J INVEST MED, V49, P119, DOI 10.2310/6650.2001.34108
   Bhattacharjee N, 2016, EUR J PHARMACOL, V791, P8, DOI 10.1016/j.ejphar.2016.08.022
   Busila C, 2017, BIOTECHNOL BIOTEC EQ, V31, P1192, DOI 10.1080/13102818.2017.1376596
   Cabandugama PK, 2017, MED CLIN N AM, V101, P129, DOI 10.1016/j.mcna.2016.08.009
   Cai SY, 2016, PHARM BIOL, V54, P2685, DOI 10.1080/13880209.2016.1178779
   Campos C, 2017, J CARDIOVASC PHARM, V69, P79, DOI 10.1097/FJC.0000000000000442
   Cao HP, 2007, ARCH BIOCHEM BIOPHYS, V459, P214, DOI 10.1016/j.abb.2006.12.034
   Charrad R, 2016, IMMUNOBIOLOGY, V221, P182, DOI 10.1016/j.imbio.2015.09.009
   Cheong AM, 2018, J FOOD SCI, V83, P854, DOI 10.1111/1750-3841.14038
   Cheraghpour M, 2019, PHYTOTHER RES, V33, P2118, DOI 10.1002/ptr.6406
   Chi C, 2020, EUR J PHARM SCI, V144, DOI 10.1016/j.ejps.2020.105212
   Choudhari VP, 2017, J AYURVEDA INTEGR ME, V8, P218, DOI 10.1016/j.jaim.2016.11.002
   Chowdhury A, 2017, IN VITRO CELL DEV-AN, V53, P483, DOI 10.1007/s11626-017-0136-3
   Cignarella A, 1996, THROMB RES, V84, P311, DOI 10.1016/S0049-3848(96)00195-8
   Crawford P, 2009, J AM BOARD FAM MED, V22, P507, DOI 10.3122/jabfm.2009.05.080093
   Dai BB, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0767-z
   Daisy P, 2012, INT J NANOMED, V7, P1189, DOI 10.2147/IJN.S26650
   Dalvand S, 2017, MED SURG NURS J, V5, P1
   Danhier F, 2012, J CONTROL RELEASE, V161, P505, DOI 10.1016/j.jconrel.2012.01.043
   Das D, 2013, COLLOID SURFACE B, V111, P556, DOI 10.1016/j.colsurfb.2013.06.041
   de Freitas LM, 2017, AM J TRANSL RES, V9, P2050
   Dey TK, 2012, FOOD RES INT, V49, P72, DOI 10.1016/j.foodres.2012.07.056
   Di Lorenzo C, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/782461
   Ebrahimi-Mameghani M, 2018, J INTEGR MED-JIM, V16, P329, DOI 10.1016/j.joim.2018.05.006
   Ebrahimzadeh-Bideskan AR, 2016, METAB BRAIN DIS, V31, P1123, DOI 10.1007/s11011-016-9837-7
   Ehrhart-Bornstein M, 2003, P NATL ACAD SCI USA, V100, P14211, DOI 10.1073/pnas.2336140100
   El-Far YM, 2016, NANOMEDICINE-UK, V11, P2581, DOI 10.2217/nnm-2016-0204
   El-Menshawe SF, 2018, INT J NANOMED, V13, P307, DOI 10.2147/IJN.S153429
   Eleazu CO, 2013, J DIABETES RES, V2013, DOI 10.1155/2013/160964
   Fangueiro JF, 2015, EUR J PHARM BIOPHARM, V95, P307, DOI 10.1016/j.ejpb.2014.12.023
   Feldeisen SE, 2007, APPL PHYSIOL NUTR ME, V32, P46, DOI 10.1139/h06-101
   Firouzi S, 2018, DIABETES METAB SYNDR, V11, P699, DOI 10.2147/DMSO.S181572
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Ganesan P, 2018, INT J NANOMED, V13, P1569, DOI 10.2147/IJN.S155593
   Ganesan P, 2017, INT J NANOMED, V12, P1097, DOI 10.2147/IJN.S124601
   Gao C., 2013, J DRUG METAB TOXICOL, V4, P159
   Campoy AHG, 2018, INT J NANOMED, V13, P2601, DOI 10.2147/IJN.S163714
   Garcia-Mediavilla V, 2003, PHARMACOL TOXICOL, V92, P94, DOI 10.1034/j.1600-0773.2003.920206.x
   Garg A., 2016, Eur. J. Biomed. Pharm. Sci, V3, P605
   Gera M, 2017, ONCOTARGET, V8, P66680, DOI 10.18632/oncotarget.19164
   Ghanbarzadeh B, 2016, FOOD BIOSCI, V15, P126, DOI 10.1016/j.fbio.2016.07.006
   Ghasemiyeh P, 2018, RES PHARM SCI, V13, P288, DOI 10.4103/1735-5362.235156
   Gordillo-Galeano A, 2018, EUR J PHARM BIOPHARM, V133, P285, DOI 10.1016/j.ejpb.2018.10.017
   Grigoras A, 2018, ANN ANAT, V219, P102, DOI 10.1016/j.aanat.2018.06.004
   Grundy SM, 2016, TRENDS CARDIOVAS MED, V26, P364, DOI 10.1016/j.tcm.2015.10.004
   Hassani FV, 2016, N-S ARCH PHARMACOL, V389, P931, DOI 10.1007/s00210-016-1256-0
   Hosseini A, 2018, IRAN J BASIC MED SCI, V21, P1091, DOI 10.22038/IJBMS.2018.31243.7529
   Hu TJ, 2019, J BIOL CHEM, V294, P8640, DOI 10.1074/jbc.RA118.007006
   Huang ZB, 2019, ACTA PHARMACOL SIN, V40, P1404, DOI 10.1038/s41401-019-0213-0
   Kanis LA, 2012, PARASITOL RES, V110, P1173, DOI 10.1007/s00436-011-2610-2
   Karthick V, 2014, COLLOID SURFACE B, V122, P505, DOI 10.1016/j.colsurfb.2014.07.022
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kesharwani P, 2018, DIABETES RES CLIN PR, V136, P52, DOI 10.1016/j.diabres.2017.11.018
   Khan ZU, 2017, J PHOTOCH PHOTOBIO B, V173, P150, DOI 10.1016/j.jphotobiol.2017.05.034
   Khoei HH, 2019, TOXIN REV, V38, P223, DOI 10.1080/15569543.2018.1444641
   Khorasani S, 2018, TRENDS FOOD SCI TECH, V79, P106, DOI 10.1016/j.tifs.2018.07.009
   Kikuchi N, 2018, CIRCULATION, V138, P600, DOI 10.1161/CIRCULATIONAHA.117.033113
   Kosina P, 2019, MOLECULES, V24, DOI 10.3390/molecules24010061
   Kuppusamy P, 2015, SAUDI J BIOL SCI, V22, P293, DOI 10.1016/j.sjbs.2014.09.016
   Langle A, 2015, REV BRAS FARMACOGN, V25, P145, DOI 10.1016/j.bjp.2015.03.004
   Lee YS, 2018, NUTRIENTS, V10, DOI 10.3390/nu10081087
   Cardozo CML, 2018, MOLECULES, V23, DOI 10.3390/molecules23092336
   López T, 2011, INT J NANOMED, V6, P19, DOI 10.2147/IJN.S13223
   Lopez T, 2010, NANOMED-NANOTECHNOL, V6, P777, DOI 10.1016/j.nano.2010.04.007
   Losi P, 2013, ACTA BIOMATER, V9, P7814, DOI 10.1016/j.actbio.2013.04.019
   Lu BY, 2010, J FOOD SCI, V75, pH205, DOI 10.1111/j.1750-3841.2010.01716.x
   Ma J, 2004, J AGR FOOD CHEM, V52, P5873, DOI 10.1021/jf049950k
   Madane RG, 2016, DRUG DELIV, V23, P1326, DOI 10.3109/10717544.2014.975382
   Maity S, 2017, CARBOHYD POLYM, V170, P124, DOI 10.1016/j.carbpol.2017.04.066
   Manna K, 2019, INT J NANOMED, V14, P1753, DOI 10.2147/IJN.S176013
   Perez-Gutierrez RM, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/9156510
   Martineau LC, 2006, PHYTOMEDICINE, V13, P612, DOI 10.1016/j.phymed.2006.08.005
   Meghwani Himanshu, 2018, Medicines (Basel), V5, DOI 10.3390/medicines5020034
   Mittal AK, 2013, BIOTECHNOL ADV, V31, P346, DOI 10.1016/j.biotechadv.2013.01.003
   Mnonopi N, 2012, PHYTOMEDICINE, V19, P488, DOI 10.1016/j.phymed.2011.12.008
   Muniandy K, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/3142073
   Nagajyothi PC, 2014, BIOORG MED CHEM LETT, V24, P4298, DOI 10.1016/j.bmcl.2014.07.023
   Nakhlband A, 2018, COLLOID SURFACE B, V164, P299, DOI 10.1016/j.colsurfb.2018.01.046
   Naseri R, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01310
   Neha, 2013, INT J PHARM BIO SCI, V4, P296
   Odei-Addo F, 2017, 3 BIOTECH, V7, DOI 10.1007/s13205-017-0986-0
   Oh YS, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00384
   Volpe CMO, 2018, CELL DEATH DIS, V9, DOI 10.1038/s41419-017-0135-z
   Ong YS, 2016, INT J NANOMED, V11, P5905, DOI 10.2147/IJN.S114205
   Opris R, 2017, COLLOID SURFACE B, V150, P192, DOI 10.1016/j.colsurfb.2016.11.033
   Ota A, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00436
   Ovais M, 2016, NANOMEDICINE-UK, V11, DOI 10.2217/nnm-2016-0279
   Pan Y, 2018, PHARMACOL RES, V130, P438, DOI 10.1016/j.phrs.2018.02.020
   Paul D, 2014, J FOOD SCI TECH MYS, V51, P1724, DOI 10.1007/s13197-014-1257-2
   Paulke A, 2013, J ETHNOPHARMACOL, V148, P492, DOI 10.1016/j.jep.2013.04.044
   Payab M, 2020, PHYTOTHER RES, V34, P526, DOI 10.1002/ptr.6547
   Peng CH, 2014, J AGR FOOD CHEM, V62, P9736, DOI 10.1021/jf5024092
   Pereira MC, 2018, FOOD CHEM, V240, P396, DOI 10.1016/j.foodchem.2017.07.144
   Perez RM, 1998, PHYTOTHER RES, V12, P144, DOI 10.1002/(SICI)1099-1573(199803)12:2<144::AID-PTR202>3.0.CO;2-H
   Plourde M, 2006, NUTR METAB, V3, DOI 10.1186/1743-7075-3-8
   Ponnanikajamideen M, 2016, Res J Pharm Technol, V9, P1204, DOI [10.5958/0974-360X.2016.00230.4, DOI 10.5958/0974-360X.2016.00230.4]
   Ponnanikajamideen M, 2019, CAN J DIABETES, V43, P82, DOI 10.1016/j.jcjd.2018.05.006
   Ponnappan N., 2015, PHARM MED, V29, P155, DOI [DOI 10.1007/s40290-015-0096-4, 10.1007/s40290-015-0096-4]
   Prabhu S, 2018, J DIABETES, V10, P28, DOI 10.1111/1753-0407.12554
   Priyanka K, 2018, J DRUG DELIV SCI TEC, V43, P94, DOI 10.1016/j.jddst.2017.08.006
   Pucci G, 2017, PHARMACOL RES, V120, P34, DOI 10.1016/j.phrs.2017.03.008
   Qu Z, 2016, NEUROL RES, V38, P831, DOI 10.1080/01616412.2016.1200766
   Ragavan G, 2017, FOOD CHEM TOXICOL, V105, P203, DOI 10.1016/j.fct.2017.04.019
   Rasheed HM, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/279247
   Rehana D, 2017, BIOPROC BIOSYST ENG, V40, P943, DOI 10.1007/s00449-017-1758-2
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Ronok Zahan Ronok Zahan, 2011, Pharmacognosy Journal, V3, P86
   Rübsam A, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19040942
   Saedisomeolia A, 2019, J HERB MED, V16, DOI 10.1016/j.hermed.2018.10.004
   Saha SS, 2012, BRIT J NUTR, V108, P974, DOI 10.1017/S0007114511006325
   Samadder A, 2012, J ACUPUNCT MERIDIAN, V5, P310, DOI 10.1016/j.jams.2012.09.001
   Samadder A, 2011, EUR J PHARM SCI, V44, P207, DOI 10.1016/j.ejps.2011.07.012
   Sambu NK, 2015, J CLIN DIAGN RES, V9, pBF1, DOI 10.7860/JCDR/2015/13374.5860
   Saratale GD, 2017, J CLUST SCI, V28, P1709, DOI 10.1007/s10876-017-1179-z
   Sarmento B, 2007, INT J NANOMED, V2, P743
   Shehab G. M., 2018, ANN RES REV BIOL, V26, P1, DOI [10.1080/0886022X.2016.1207053, DOI 10.1080/0886022X.2016.1207053]
   Sheng JY, 2016, J CONTROL RELEASE, V233, P181, DOI 10.1016/j.jconrel.2016.05.015
   Shi J, 2004, J MED FOOD, V7, P67, DOI 10.1089/109662004322984734
   Singh BP, 2014, PEPTIDES, V54, P171, DOI 10.1016/j.peptides.2014.01.022
   Singh D, 2011, J ETHNOPHARMACOL, V134, P565, DOI 10.1016/j.jep.2011.01.046
   Singh Shiv Vardan, 2016, Journal of Basic and Clinical Physiology and Pharmacology, V27, P121, DOI 10.1515/jbcpp-2015-0017
   Singhal Ak, 2011, Int J Appl Basic Med Res, V1, P36, DOI 10.4103/2229-516X.81978
   Singla R, 2019, NAT PROD RES, V33, P548, DOI 10.1080/14786419.2017.1395433
   Singla R, 2017, INT J BIOL MACROMOL, V105, P45, DOI 10.1016/j.ijbiomac.2017.06.109
   Singla R, 2017, CARBOHYD POLYM, V155, P152, DOI 10.1016/j.carbpol.2016.08.065
   Sriramavaratharajan V, 2019, NAT PROD RES, V33, P2430, DOI 10.1080/14786419.2018.1446137
   Subramani K, 2012, DIG J NANOMATER BIOS, V7, P85
   Sun YE, 2018, MEDICINE, V97, DOI [10.1097/md.0000000000010255, 10.1097/MD.0000000000010255]
   Surendiran A, 2009, INDIAN J MED RES, V130, P689
   Tachibana Y, 2001, J AGR FOOD CHEM, V49, P5589, DOI 10.1021/jf010621r
   Taghipour YD, 2019, INT J NANOMED, V14, P5303, DOI 10.2147/IJN.S213831
   Tajmohammadi A, 2018, PHYTOTHER RES, V32, P1933, DOI 10.1002/ptr.6153
   Dinh T, 2012, DIABETES, V61, P2937, DOI 10.2337/db12-0227
   Tsuzuki T, 2006, J NUTR, V136, P2153, DOI 10.1093/jn/136.8.2153
   Vaziri ND, 2005, KIDNEY INT, V68, P2787, DOI 10.1111/j.1523-1755.2005.00750.x
   Vishram JKK, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0107294
   Volf I, 2014, CHEM PAP, V68, P121, DOI 10.2478/s11696-013-0417-6
   Wang X, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055899
   Wei YF, 2019, SOFT MATTER, V15, P7956, DOI 10.1039/c9sm00902g
   Wilczewska AZ, 2012, PHARMACOL REP, V64, P1020, DOI 10.1016/S1734-1140(12)70901-5
   Wu ZH, 2004, ACTA PHARMACOL SIN, V25, P966
   Xi B, 2013, PREV MED, V57, P867, DOI 10.1016/j.ypmed.2013.09.023
   Xiang LL, 2018, PULM CIRC, V8, DOI 10.1177/2045894018784033
   Xu DQ, 2016, INT J MED SCI, V13, P942, DOI 10.7150/ijms.16810
   Xu LS, 2019, J PHOTOCH PHOTOBIO B, V196, DOI 10.1016/j.jphotobiol.2019.04.011
   Xu T, 2017, REDOX BIOL, V11, P286, DOI 10.1016/j.redox.2016.12.019
   Xu Z, 2016, SCI REP-UK, V6, DOI 10.1038/srep30252
   Yadav T. C., 2019, Adv. Funct. Text. Polym.: Fabrication, Process. Appl., P365
   Yeh PT, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0146438
   Zarfeshany Aida, 2014, Adv Biomed Res, V3, P100, DOI 10.4103/2277-9175.129371
   Zhang MZ, 2018, J CROHNS COLITIS, V12, P217, DOI 10.1093/ecco-jcc/jjx115
   Zhang MZ, 2016, BIOMATERIALS, V101, P321, DOI 10.1016/j.biomaterials.2016.06.018
   Zhang XW, 2014, NANOSCALE RES LETT, V9, DOI 10.1186/1556-276X-9-185
   Zheng HM, 2013, J FOOD SCI, V78, pN1301, DOI 10.1111/1750-3841.12208
NR 181
TC 31
Z9 32
U1 2
U2 18
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-4185
J9 FRONT BIOENG BIOTECH
JI Front. Bioeng. Biotechnol.
PD MAY 14
PY 2020
VL 8
AR 425
DI 10.3389/fbioe.2020.00425
PG 18
WC Biotechnology & Applied Microbiology; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Engineering
GA LV5VR
UT WOS:000538503000001
PM 32478050
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Dupas, J
   Feray, A
   Goanvec, C
   Guernec, A
   Samson, N
   Bougaran, P
   Guerrero, F
   Mansourati, J
AF Dupas, Julie
   Feray, Annie
   Goanvec, Christelle
   Guernec, Anthony
   Samson, Nolwenn
   Bougaran, Pauline
   Guerrero, Francois
   Mansourati, Jacques
TI Metabolic Syndrome and Hypertension Resulting from Fructose Enriched
   Diet in Wistar Rats
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID TYPE-2 DIABETES-MELLITUS; FATTY LIVER-DISEASE; INSULIN-RESISTANCE;
   GLUCOSE-TOLERANCE; OXIDATIVE STRESS; HOMA-IR; PATHOPHYSIOLOGY;
   HOMEOSTASIS; PREVALENCE; PARAMETERS
AB Increased sugar consumption, especially fructose, is strongly related to the development of type 2 diabetes (T2D) and metabolic syndrome. The aim of this study was to evaluate long term effects of fructose supplementation on Wistar rats. Three-week-oldmale rats were randomly divided into 2 groups: control (C;n = 14) and fructose fed (FF;n = 18), with a fructose enriched drink (20-25% w/v fructose in water) for 21 weeks. Systolic blood pressure, fasting glycemia, and bodyweight were regularly measured. Glucose tolerance was evaluated three times using an oral glucose tolerance test. Insulin levels were measured concomitantly and insulin resistance markers were evaluated (HOMA 2-IR, Insulin Sensitivity Index for glycemia (ISI-gly)). Lipids profile was evaluated on plasma. This fructose supplementation resulted in the early induction of hypertension without renal failure (stable theoretical creatinine clearance) and in the progressive development of fasting hyperglycemia and insulin resistance (higher HOMA 2-IR, lower ISI-gly) without modification of glucose tolerance. FF rats presented dyslipidemia (higher plasma triglycerides) and early sign of liver malfunction (higher liver weight). Although abdominal fat weight was increased in FF rats, no significant overweight was found. In Wistar rats, 21 weeks of fructose supplementation induced a metabolic syndrome (hypertension, insulin resistance, and dyslipidemia) but not T2D.
C1 [Dupas, Julie; Feray, Annie; Goanvec, Christelle; Guernec, Anthony; Bougaran, Pauline; Guerrero, Francois; Mansourati, Jacques] Univ Bretagne Occidentale, Inst Brestois Sant Agro Mat, EA 4324 Optimisat Regulat Physiol, 6 Ave Victor Le Gorgeu, F-29238 Brest 3, France.
   [Feray, Annie; Guernec, Anthony; Guerrero, Francois] UFR Sci Sport & Educ, 20 Ave Victor Le Gorgeu, F-29238 Brest 3, France.
   [Goanvec, Christelle] UFR Sci & Tech, 6 Ave Victor Le Gorgeu, F-29238 Brest 3, France.
   [Samson, Nolwenn] Univ Laval, Inst Univ Cardiol & Pneumol Quebec, 2725 Chemin Ste Foy, Quebec City, PQ G1V 4G5, Canada.
   [Mansourati, Jacques] CHU Brest, Dept Cardiol, Blvd Tanguy Prigent, F-29200 Brest, France.
C3 Universite de Bretagne Occidentale; Laval University; Laval University
   Hospital; CHU Brest
RP Goanvec, C (corresponding author), Univ Bretagne Occidentale, Inst Brestois Sant Agro Mat, EA 4324 Optimisat Regulat Physiol, 6 Ave Victor Le Gorgeu, F-29238 Brest 3, France.; Goanvec, C (corresponding author), UFR Sci & Tech, 6 Ave Victor Le Gorgeu, F-29238 Brest 3, France.
EM christelle.goanvec@univ-brest.fr
RI Mansourati, Jacques/HLQ-5147-2023
OI Bougaran, Pauline/0000-0002-4064-2388; Guerrero,
   Francois/0000-0002-0283-3503; goanvec, christelle/0000-0002-1764-6778
FU Nathalie Guegueniat (Optimisation des Regulations Physiologiques,
   Universite de Bretagne Occidentale, Brest, France) [EA 4324]; Federation
   Francaise de Cardiologie
FX Authors wish to thank Nathalie Guegueniat (EA 4324-Optimisation des
   Regulations Physiologiques, Universite de Bretagne Occidentale, Brest,
   France) for her help in this project. This study was partially funded by
   the Federation Francaise de Cardiologie.
CR Aydin A, 2001, CLIN BIOCHEM, V34, P65, DOI 10.1016/S0009-9120(00)00199-5
   Belfiore F, 1998, MOL GENET METAB, V63, P134, DOI 10.1006/mgme.1997.2658
   Bettaieb A, 2014, FREE RADICAL BIO MED, V72, P247, DOI 10.1016/j.freeradbiomed.2014.04.011
   Bhatia S, 2003, CLIN BIOCHEM, V36, P557, DOI 10.1016/S0009-9120(03)00094-8
   Bloch KD, 2005, TRENDS CARDIOVAS MED, V15, P249, DOI 10.1016/j.tcm.2005.07.005
   Botezelli JD, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-116
   Chen T, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1176-z
   COCKCROFT DW, 1976, NEPHRON, V16, P31, DOI 10.1159/000180580
   de Moura RF, 2009, BRIT J NUTR, V101, P1178, DOI 10.1017/S0007114508066774
   Dehghan A, 2008, DIABETES CARE, V31, P361, DOI 10.2337/dc07-1276
   Dimo T, 2002, J ETHNOPHARMACOL, V83, P183, DOI 10.1016/S0378-8741(02)00162-9
   Dupas J, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0146821
   Elliott SS, 2002, AM J CLIN NUTR, V76, P911, DOI 10.1093/ajcn/76.5.911
   Francini F, 2010, LIFE SCI, V86, P965, DOI 10.1016/j.lfs.2010.05.005
   Gayoso-Diz P, 2013, BMC ENDOCR DISORD, V13, DOI 10.1186/1472-6823-13-47
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Haeri MR, 2009, PHYTOTHER RES, V23, P61, DOI 10.1002/ptr.2557
   Havel PJ, 2005, NUTR REV, V63, P133, DOI [10.1301/nr.2005.may.133-157, 10.1111/j.1753-4887.2005.tb00132.x]
   Huang BW, 2004, DIABETES OBES METAB, V6, P120, DOI 10.1111/j.1462-8902.2004.00323.x
   Hurst J.W., 1990, CLIN METHODS HIST PH, V3rd
   HWANG IS, 1987, HYPERTENSION, V10, P512, DOI 10.1161/01.HYP.10.5.512
   Lamarche B, 1999, DIABETES METAB, V25, P199
   Lírio LM, 2016, J DIABETES COMPLICAT, V30, P85, DOI 10.1016/j.jdiacomp.2015.10.008
   Lozano I, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0074-1
   Mamikutty N, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/263897
   Matsuda M, 1999, DIABETES CARE, V22, P1462, DOI 10.2337/diacare.22.9.1462
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mellouk Z, 2011, INT J MOL MED, V28, P1087, DOI 10.3892/ijmm.2011.781
   Moore JB, 2014, NUTRIENTS, V6, P5679, DOI 10.3390/nu6125679
   Ndlovu T, 2007, AFR J BIOTECHNOL, V6, P2727
   PICKART L, 1983, ATHEROSCLEROSIS, V46, P21, DOI 10.1016/0021-9150(83)90160-0
   Pranprawit A, 2013, J SCI FOOD AGR, V93, P3191, DOI 10.1002/jsfa.6240
   Rector RS, 2010, AM J PHYSIOL-ENDOC M, V298, pE1179, DOI 10.1152/ajpendo.00703.2009
   Reiser S, 1985, Nutr Health, V3, P203
   Ribeiro R, 2005, DIABETOLOGIA, V48, P976, DOI 10.1007/s00125-005-1714-6
   RODIN J, 1991, APPETITE, V17, P213, DOI 10.1016/0195-6663(91)90023-L
   Schianca GPC, 2006, DIABETES-METAB RES, V22, P111, DOI 10.1002/dmrr.560
   Seghrouchni I, 2002, CLIN CHIM ACTA, V321, P89, DOI 10.1016/S0009-8981(02)00099-2
   Susztak K, 2006, DIABETES, V55, P225, DOI 10.2337/diabetes.55.1.225
   Szabo C, 2007, NAT REV DRUG DISCOV, V6, P662, DOI 10.1038/nrd2222
   Tappy L, 2010, PHYSIOL REV, V90, P23, DOI 10.1152/physrev.00019.2009
   Whiting DR, 2011, DIABETES RES CLIN PR, V94, P311, DOI 10.1016/j.diabres.2011.10.029
   Wild S, 2004, DIABETES CARE, V27, P1047, DOI 10.2337/diacare.27.5.1047
   Wright E, 2006, INT J CLIN PRACT, V60, P308, DOI 10.1111/j.1368-5031.2006.00825.x
   Yoshida Akihiro, 2004, J Atheroscler Thromb, V11, P215
   Yu SJ, 2010, BIOORG CHEM, V38, P159, DOI 10.1016/j.bioorg.2010.03.001
   Yuan G, 2007, ENDOCRINOLOGY, V148, P2016, DOI 10.1210/en.2006-0602
   Zweier JL, 2011, ANTIOXID REDOX SIGN, V14, P1769, DOI 10.1089/ars.2011.3904
NR 48
TC 52
Z9 57
U1 0
U2 6
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2017
VL 2017
AR 2494067
DI 10.1155/2017/2494067
PG 10
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA ES9UF
UT WOS:000399906200001
PM 28497040
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Pervanidou, P
   Chrousos, GP
AF Pervanidou, P.
   Chrousos, G. P.
TI Post-traumatic stress disorder in children and adolescents: From sigmund
   Freud's "Trauma" to psychopathology and the (Dys)metabolic syndrome
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article; Proceedings Paper
CT Symposium on Cortisol Secretion Abnormalities
CY JUN, 2006
CL Bethesda, MD
SP NICHD
DE child development; salivary cortisol; catecholamines; brain; behavior
ID URINARY CATECHOLAMINE EXCRETION; CORTISOL-LEVELS; PTSD SYMPTOMS; PLASMA
   NOREPINEPHRINE; HOLOCAUST SURVIVORS; HIPPOCAMPAL VOLUME; SALIVARY
   CORTISOL; VIETNAM VETERANS; BASAL CORTISOL; SEXUAL-ABUSE
AB Post-traumatic Stress Disorder (PTSD) is an anxiety syndrome that develops after exposure to traumatic life events. Symptoms include reexperience of the initial trauma, avoidance of stimuli associated with the trauma and symptoms of excessive arousal. Neuroenclocrine studies in adults with PTSD have demonstrated that basal cerebrospinal fluid (CSF) CRH levels are elevated and urinary cortisol levels are variable - low in the majority of cases - whereas other studies demonstrate no differences in urinary and plasma cortisol concentrations. Urinary catecholamine excretion is higher in PTSD patients than those of control subjects and other psychiatric disorders.
   Children may differ from adults in their psychologic and physiologic responses to severe stressors. Also, exposure to stress during critical periods of development may have irreversible effects on behavioral maturation and may affect specific vulnerable brain areas, altering CNS development. Similar to findings in adult studies, PTSD in children is characterized by increased sympathetic nervous system (SNS) activity, as indicated by elevated norepinephrine levels in the periphery. High cortisol levels in urine or saliva have been reported in most studies of childhood PTSD, while prospective longitudinal studies concerning the natural history of neuroendocrine changes in pediatric PTSD after an acute stressor are limited. The identification of neurobiologic changes in response to early adverse experiences is of major importance for the prognosis, prevention, management, and treatment of children and adolescents at risk for or suffering from PTSD.
C1 Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Dept Pediat 1, Athens, Greece.
C3 Athens Medical School; National & Kapodistrian University of Athens; The
   Aghia Sophia Children's Hospital
RP Pervanidou, P (corresponding author), Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Dept Pediat 1, Thivon & Levadias St, Athens, Greece.
EM ppervanid@med.uoa.gr
RI Pervanidou, Panagiota/ABI-6356-2020
OI Pervanidou, Panagiota/0000-0002-6593-6489
CR Baker DG, 1999, AM J PSYCHIAT, V156, P585
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   BLANCHARD EB, 1991, J NERV MENT DIS, V179, P371, DOI 10.1097/00005053-199106000-00012
   Bokanowski T, 2005, INT J PSYCHOANAL, V86, P251, DOI 10.1516/PPLT-H9DR-DW3A-X1XU
   Boscarino JA, 1996, J CONSULT CLIN PSYCH, V64, P191, DOI 10.1037/0022-006X.64.1.191
   Bremner JD, 1997, BIOL PSYCHIAT, V41, P23, DOI 10.1016/S0006-3223(96)00162-X
   BREMNER JD, 1995, AM J PSYCHIAT, V152, P973
   Bremner JD, 1997, AM J PSYCHIAT, V154, P624
   CAHILL L, 1994, NATURE, V371, P702, DOI 10.1038/371702a0
   Carrion VG, 2002, BIOL PSYCHIAT, V51, P575, DOI 10.1016/S0006-3223(01)01310-5
   Charmandari E, 2003, HORM RES, V59, P161, DOI 10.1159/000069325
   Charmandari E, 2005, ANNU REV PHYSIOL, V67, P259, DOI 10.1146/annurev.physiol.67.040403.120816
   Chrousos G P., 2002, Pediatric Endocrinology, P1
   Chrousos GP, 1999, SER AFFECTIVE SCI, P193
   CHROUSOS GP, 1992, JAMA-J AM MED ASSOC, V267, P1244, DOI 10.1001/jama.267.9.1244
   Cicchetti D, 2001, DEV PSYCHOPATHOL, V13, P677, DOI 10.1017/S0954579401003145
   De Bellis MD, 1999, BIOL PSYCHIAT, V45, P1259, DOI 10.1016/S0006-3223(99)00044-X
   De Bellis MD, 1999, BIOL PSYCHIAT, V45, P1271, DOI 10.1016/S0006-3223(99)00045-1
   De Bellis Michael D, 2003, Curr Psychiatry Rep, V5, P108
   DEBELLIS MD, 1994, J CLIN ENDOCR METAB, V78, P249, DOI 10.1210/jc.78.2.249
   DEBELLIS MD, 1994, J AM ACAD CHILD PSY, V33, P320, DOI 10.1097/00004583-199403000-00004
   DEBLINGER E, 1989, CHILD ABUSE NEGLECT, V13, P403, DOI 10.1016/0145-2134(89)90080-X
   Delahanty DL, 2005, PSYCHONEUROENDOCRINO, V30, P121, DOI 10.1016/j.psyneuen.2004.06.004
   Delahanty DL, 2000, BIOL PSYCHIAT, V48, P940, DOI 10.1016/S0006-3223(00)00896-9
   Famularo R, 1996, CHILD ABUSE NEGLECT, V20, P953, DOI 10.1016/0145-2134(96)00084-1
   FREUD Sigmund., 1973, INTRO LECT PSYCHOANA
   Geracioti TD, 2001, AM J PSYCHIAT, V158, P1227, DOI 10.1176/appi.ajp.158.8.1227
   Goenjian AK, 1996, AM J PSYCHIAT, V153, P929
   Gold PW, 2005, P NATL ACAD SCI USA, V102, P8303, DOI 10.1073/pnas.0503069102
   *INT U PRESS INC, 1998, CHILDR TRAUM STRESSF
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   KISER LJ, 1991, J AM ACAD CHILD PSY, V30, P776, DOI 10.1016/S0890-8567(10)80015-2
   KOSTEN TR, 1987, PSYCHONEUROENDOCRINO, V12, P13, DOI 10.1016/0306-4530(87)90017-5
   MASON JW, 1986, J NERV MENT DIS, V174, P145, DOI 10.1097/00005053-198603000-00003
   MASON JW, 1988, J NERV MENT DIS, V176, P498, DOI 10.1097/00005053-198808000-00008
   McEwen BS, 2004, ANN NY ACAD SCI, V1032, P1, DOI 10.1196/annals.1314.001
   Mittal VA, 2011, PSYCHIAT RES, V189, P158, DOI 10.1016/j.psychres.2011.06.006
   Murburg MM, 1995, BIOL PSYCHIAT, V38, P819, DOI 10.1016/0006-3223(95)00044-5
   PERVANIDOU P, 2006, END SOC 88 ANN ME BO, P24
   PERVANIDOU P, 2007, IN PRESS BIOL PSYCHI
   PITMAN RK, 1990, BIOL PSYCHIAT, V27, P245, DOI 10.1016/0006-3223(90)90654-K
   Rosmond R, 2005, PSYCHONEUROENDOCRINO, V30, P1, DOI 10.1016/j.psyneuen.2004.05.007
   Southwick S M, 1999, Semin Clin Neuropsychiatry, V4, P242
   Southwick SM, 1999, BIOL PSYCHIAT, V46, P1192, DOI 10.1016/S0006-3223(99)00219-X
   Strawn JR, 2004, PSYCHOSOM MED, V66, P757, DOI 10.1097/01.psy.0000138133.72365.45
   Szabo S, 1998, ANN NY ACAD SCI, V851, P19, DOI 10.1111/j.1749-6632.1998.tb08972.x
   Teicher MH, 2002, PSYCHIAT CLIN N AM, V25, P397, DOI 10.1016/S0193-953X(01)00003-X
   TERR LC, 1991, AM J PSYCHIAT, V148, P10
   Thaller V, 1999, COLLEGIUM ANTROPOL, V23, P611
   YEHUDA R, 1990, J NERV MENT DIS, V178, P366, DOI 10.1097/00005053-199006000-00004
   YEHUDA R, 1992, J NERV MENT DIS, V180, P321, DOI 10.1097/00005053-199205000-00006
   YEHUDA R, 1991, AM J PSYCHIAT, V148, P499
   YEHUDA R, 1994, ANN NY ACAD SCI, V746, P378
   Yehuda R, 2002, NEW ENGL J MED, V346, P108, DOI 10.1056/NEJMra012941
   Yehuda R, 2005, J CLIN ENDOCR METAB, V90, P4115, DOI 10.1210/jc.2005-0550
   Yehuda R, 2005, AM J PSYCHIAT, V162, P998, DOI 10.1176/appi.ajp.162.5.998
   Yehuda R, 2004, AM J PSYCHIAT, V161, P1397, DOI 10.1176/appi.ajp.161.8.1397
   YEHUDA R, 1991, BIOL PSYCHIAT, V30, P1031, DOI 10.1016/0006-3223(91)90123-4
   YEHUDA R, 1995, AM J PSYCHIAT, V152, P982
   YEHUDA R, 1993, AM J PSYCHIAT, V150, P83
   Yehuda R, 1998, BIOL PSYCHIAT, V44, P56, DOI 10.1016/S0006-3223(98)80007-3
   Yehuda R, 2001, J CLIN PSYCHIAT, V62, P41
   Yule W., 1990, J TRAUMA STRESS, V3, P279
NR 63
TC 48
Z9 52
U1 0
U2 22
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD JUN
PY 2007
VL 39
IS 6
BP 413
EP 419
DI 10.1055/s-2007-981461
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism
GA 185SP
UT WOS:000247731000003
PM 17578757
DA 2025-06-11
ER

PT J
AU Yeom, S
   Lee, DH
   Song, J
AF Yeom, Sujung
   Lee, Dong Hoon
   Song, Juhyun
TI Therapeutic Potential of Anti-Diabetes Drugs and Anti-Dyslipidemia Drugs
   to Mitigate Head and Neck Cancer Risk in Metabolic Syndrome
SO CNS NEUROSCIENCE & THERAPEUTICS
LA English
DT Review
DE anti-diabetic drugs; anti-dyslipidemic drugs; head and neck cancer
   (HNC); metabolic syndrome (Mets)
ID BODY-MASS INDEX; ENDOMETRIAL CANCER; PPAR-GAMMA; SIGNALING PATHWAY;
   COLORECTAL-CANCER; OXIDATIVE STRESS; BREAST-CANCER; CELL-PROLIFERATION;
   INSULIN-RESISTANCE; STEM-CELLS
AB BackgroundHead and neck cancer (HNC) encompasses a heterogeneous group of malignancies originating in the oral cavity, pharynx, nasopharynx, larynx, paranasal sinuses, and salivary glands. Accumulating evidence indicates that metabolic syndrome (MetS) characterized by a constellation of conditions including central adiposity, hyperglycemia, dyslipidemia, hypertension, and insulin resistance, may significantly influence cancer pathogenesis and progression.ResultsMetS has been epidemiologically linked to elevated risk for multiple malignancies through various metabolic mechanisms involving chronic systemic inflammation, insulin resistance, and dysregulated lipid metabolism. Especially in HNC, recent studies demonstrated that MetS and metabolic imbalance conditions may contribute to carcinogenesis, disease progression, and clinical outcomes, but the exact mechanisms behind the association between excess fat accumulation and HNC risk remain unclear. Considering previous studies, pharmacological agents targeting metabolic pathways, including biguanides (metformin), thiazolidinediones, sodium-glucose cotransporter-2 (SGLT-2) inhibitors, and HMG-CoA reductase inhibitors (statins) are being investigated for potential repurposing in cancer prevention and adjuvant therapy.ConclusionsHere, we summarize the latest evidence on the relationship between MetS and HNC, highlighting the therapeutic potential of anti-diabetes drugs and anti-dyslipidemia drugs in ameliorating various pathological problems in HNC patients with MetS.
C1 [Yeom, Sujung; Lee, Dong Hoon] Chonnam Natl Univ, Hwasun Hosp, Med Sch, Dept Otolaryngol Head & Neck Surg, Hwasun, South Korea.
   [Song, Juhyun] Chonnam Natl Univ, Med Sch, Dept Anat, Hwasun, South Korea.
C3 Chonnam National University; Chonnam National University
RP Lee, DH (corresponding author), Chonnam Natl Univ, Hwasun Hosp, Med Sch, Dept Otolaryngol Head & Neck Surg, Hwasun, South Korea.; Song, J (corresponding author), Chonnam Natl Univ, Med Sch, Dept Anat, Hwasun, South Korea.
EM leen3l@chonnam.ac.kr; juhyunsong@chonnam.ac.kr
FU Chonnam National University Hwasun Hospital Institute for Biomedical
   Science [RS-2022-NR069292]; National Research Foundation of Korea
   [HCRI24023]; Chonnam National University Hwasun Hospital Institute for
   Biomedical Science, Korea
FX This study was supported by grant RS-2022-NR069292 (Juhyun Song) from
   the National Research Foundation of Korea. HCRI24023 from the Chonnam
   National University Hwasun Hospital Institute for Biomedical Science,
   Korea (Juhyun Song and Dong Hoon Lee). The authors thank Biorender for
   making the figures.
CR Aguilar-Salinas Carlos A, 2019, F1000Res, V8, DOI 10.12688/f1000research.17122.1
   Alcusky M, 2019, J CLIN PHARM THER, V44, P588, DOI 10.1111/jcpt.12820
   Asiri A, 2024, DIAGNOSTICS, V14, DOI 10.3390/diagnostics14192132
   Avgerinos KI, 2019, METABOLISM, V92, P121, DOI 10.1016/j.metabol.2018.11.001
   Barsouk A, 2023, MED SCI-BASEL, V11, DOI 10.3390/medsci11020042
   Basak D, 2023, BIOMEDICINES, V11, DOI 10.3390/biomedicines11071867
   Benedetti R, 2022, PHARMACOL RES, V175, DOI 10.1016/j.phrs.2021.106039
   Bjorbæk C, 2001, J BIOL CHEM, V276, P4747, DOI 10.1074/jbc.M007439200
   Bjorge T, 2010, AM J EPIDEMIOL, V171, P892, DOI 10.1093/aje/kwq006
   Bocian-Jastrzebska A, 2023, CANCERS, V15, DOI 10.3390/cancers15174250
   Braun S, 2011, INT J BIOL SCI, V7, P1003, DOI 10.7150/ijbs.7.1003
   Bray F, 2024, CA-CANCER J CLIN, V74, P229, DOI 10.3322/caac.21834
   Bray F, 2018, CA-CANCER J CLIN, V68, P394, DOI [10.3322/caac.21492, 10.3322/caac.21609]
   Buettner C, 2006, CELL METAB, V4, P49, DOI 10.1016/j.cmet.2006.04.014
   Burotto M, 2014, ORAL ONCOL, V50, P924, DOI 10.1016/j.oraloncology.2013.12.020
   Byeon JS, 2010, INT J CANCER, V127, P2758, DOI 10.1002/ijc.25301
   Carmeci C, 1997, GENOMICS, V45, P607, DOI 10.1006/geno.1997.4972
   Carreras-Torres R, 2017, JNCI-J NATL CANCER I, V109, DOI 10.1093/jnci/djx012
   Chao EC, 2010, NAT REV DRUG DISCOV, V9, P551, DOI 10.1038/nrd3180
   Chatterjee A, 2022, DRUG DISCOV TODAY, V27, P82, DOI 10.1016/j.drudis.2021.07.007
   Chavez-Tapia NC, 2022, J HEPATOCELL CARCINO, V9, P583, DOI 10.2147/JHC.S283840
   Chen CC, 2007, ENDOCR-RELAT CANCER, V14, P513, DOI 10.1677/ERC-06-0027
   Chen YC, 2020, AM J TRANSL RES, V12, P4885
   Chen ZY, 2021, MOL METAB, V51, DOI 10.1016/j.molmet.2021.101230
   Cheng SP, 2011, ONCOL REP, V26, P1265, DOI 10.3892/or.2011.1388
   Choi SY, 2022, CANCERS, V14, DOI 10.3390/cancers14133277
   Cirillo D, 2008, J CELL BIOCHEM, V105, P956, DOI 10.1002/jcb.21911
   Conza D, 2023, CELLS-BASEL, V12, DOI 10.3390/cells12172182
   Cowey S, 2006, AM J PATHOL, V169, P1505, DOI 10.2353/ajpath.2006.051090
   Coyle C, 2016, ANN ONCOL, V27, P2184, DOI 10.1093/annonc/mdw410
   Curry JM, 2018, FRONT ONCOL, V8, DOI 10.3389/fonc.2018.00436
   Cust AE, 2007, J CLIN ENDOCR METAB, V92, P255, DOI 10.1210/jc.2006-1371
   Demierre MF, 2005, NAT REV CANCER, V5, P930, DOI 10.1038/nrc1751
   Deneuve S, 2011, ORAL ONCOL, V47, P631, DOI 10.1016/j.oraloncology.2011.04.019
   Deng CF, 2022, FRONT ONCOL, V12, DOI 10.3389/fonc.2022.803473
   Deshmukh AB, 2013, RENAL FAILURE, V35, P566, DOI 10.3109/0886022X.2013.766560
   Donato J, 2010, ARQ BRAS ENDOCRINOL, V54, P591, DOI 10.1590/S0004-27302010000700002
   dos Santos CR, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-16
   Dowling RJO, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-33
   Dutta Deep, 2012, Indian J Endocrinol Metab, V16, pS596, DOI 10.4103/2230-8210.105577
   Ebrahimi G., 2023, Open Dentistry Journal, V17
   El Homsi M, 2007, AM J PHYSIOL-GASTR L, V293, pG365, DOI 10.1152/ajpgi.00091.2007
   Esposito K, 2012, DIABETES CARE, V35, P2402, DOI 10.2337/dc12-0336
   Federico A, 2007, INT J CANCER, V121, P2381, DOI 10.1002/ijc.23192
   Ferlay J, 2019, INT J CANCER, V144, P1941, DOI 10.1002/ijc.31937
   Filaferro L, 2024, EXPERT REV ANTICANC, V24, P435, DOI 10.1080/14737140.2024.2343338
   Fröhlich E, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/845340
   Frühbeck G, 2006, BIOCHEM J, V393, P7, DOI 10.1042/BJ20051578
   Gaertner F, 2024, CANCERS, V16, DOI 10.3390/cancers16050982
   Gao JC, 2009, CANCER SCI, V100, P389, DOI 10.1111/j.1349-7006.2008.01053.x
   Gao QR, 2015, TUMOR BIOL, V36, P4287, DOI 10.1007/s13277-015-3067-1
   Garofalo C, 2006, J CELL PHYSIOL, V207, P12, DOI 10.1002/jcp.20472
   Gaudet MM, 2010, INT J EPIDEMIOL, V39, P1091, DOI 10.1093/ije/dyp380
   Giovannucci E, 2001, J NUTR, V131, p3109S, DOI 10.1093/jn/131.11.3109S
   GLICKSMAN AS, 1956, MED CLIN N AM, V40, P887, DOI 10.1016/S0025-7125(16)34572-2
   Goldberg JE, 2010, CURR DRUG TARGETS, V11, P1133
   Gormley A, 2022, BMJ OPEN, V12, DOI 10.1136/bmjopen-2021-058392
   Gormley M, 2023, ELIFE, V12, DOI 10.7554/eLife.82674
   Govindarajan R., 2017, Translational Research in Oral Oncology, V2, P1
   Grossman E, 2002, AM J MED, V112, P479, DOI 10.1016/S0002-9343(02)01049-5
   Gui L, 2023, BMC MED GENOMICS, V16, DOI 10.1186/s12920-023-01634-4
   Guzik TJ, 2017, HYPERTENSION, V70, P660, DOI 10.1161/HYPERTENSIONAHA.117.07802
   Han HD, 2017, SCI REP-UK, V7, DOI 10.1038/srep44877
   Harding JL, 2016, J HYPERTENS, V34, P149, DOI 10.1097/HJH.0000000000000770
   He ZX, 2024, SCIENCEASIA, V50, P1, DOI 10.2306/scienceasia1513-1874.2024.078/scienceasia1513-1874.2024.078
   Hegyi K, 2004, CELL BIOL INT, V28, P159, DOI 10.1016/j.cellbi.2003.12.003
   Hirsch HA, 2009, CANCER RES, V69, P7507, DOI 10.1158/0008-5472.CAN-09-2994
   Ho Jo Hyeong, 2024, [Kosin Medical Journal, 고신대학교 의과대학 학술지], V39, P26, DOI 10.7180/kmj.24.108
   Ishikane S, 2018, BIOCHEM PHARMACOL, V151, P96, DOI 10.1016/j.bcp.2018.03.008
   Ishikawa M, 2004, CLIN CANCER RES, V10, P4325, DOI 10.1158/1078-0432.CCR-03-0749
   James WPT, 2008, INT J OBESITY, V32, pS120, DOI 10.1038/ijo.2008.247
   Jiang HL, 2021, CANCER METAB, V9, DOI 10.1186/s40170-021-00261-w
   Jiang W, 2021, J EXP CLIN CANC RES, V40, DOI 10.1186/s13046-021-02041-2
   Jiao Y, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.850750
   Juarez D, 2021, TRENDS CANCER, V7, P525, DOI 10.1016/j.trecan.2020.11.008
   Jung YY, 2021, J CELL PHYSIOL, V236, P5253, DOI 10.1002/jcp.30229
   Kadowaki T, 2006, J CLIN INVEST, V116, P1784, DOI 10.1172/JCI29126
   Kasznicki J, 2014, ANN TRANSL MED, V2, DOI 10.3978/j.issn.2305-5839.2014.06.01
   Kato H, 2015, BIOCHEM BIOPH RES CO, V461, P115, DOI 10.1016/j.bbrc.2015.03.178
   Kemnade JO, 2023, ORAL ONCOL, V145, DOI 10.1016/j.oraloncology.2023.106536
   Kim GJ, 2023, CANCERS, V15, DOI 10.3390/cancers15164118
   Kim SY, 2015, BRAZ J MED BIOL RES, V48, P226, DOI [10.1590/1414-431X20144212, 10.1590/1414-431x20144212]
   Kim SY, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-37061-0
   Komatsu S, 2020, ENDOCR J, V67, P99, DOI 10.1507/endocrj.EJ19-0428
   Kwon M, 2015, ONCOLOGIST, V20, P546, DOI 10.1634/theoncologist.2014-0426
   Law M, 2006, AM J CARDIOL, V97, p52C, DOI 10.1016/j.amjcard.2005.12.010
   Lee DJ, 2019, J OTOLARYNGOL-HEAD N, V48, DOI 10.1186/s40463-019-0348-5
   Lee HP, 2015, ONCOTARGET, V6, P36746, DOI 10.18632/oncotarget.5479
   Lei Y, 2017, CHIN J CANCER, V36, DOI 10.1186/s40880-017-0184-9
   Li L., 2024, Nasopharyngeal Carcinoma and Head and Neck Cancer in Patients With Type2 Diabetes Mellitus Receiving SGLT2I, DPP4I or GLP1a: A PopulationBased Cohort Study,
   Li LR, 2023, DISCOV ONCOL, V14, DOI 10.1007/s12672-022-00599-7
   Lin J, 2025, BRIT J CANCER, V132, P259, DOI 10.1038/s41416-024-02925-y
   Lin YC, 2014, ONCOTARGET, V5, P298, DOI 10.18632/oncotarget.1628
   Liu HM, 2021, NUTR METAB, V18, DOI 10.1186/s12986-021-00569-w
   Lopez R, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0079708
   Lösel R, 2003, NAT REV MOL CELL BIO, V4, P46, DOI 10.1038/nrm1009
   Luo JH, 2023, BRIT J CANCER, V128, P1541, DOI 10.1038/s41416-023-02177-2
   Lyles BE, 2009, CELL CYCLE, V8, P268, DOI 10.4161/cc.8.2.7584
   Ma SJ, 2023, JAMA NETW OPEN, V6, DOI 10.1001/jamanetworkopen.2023.20513
   Macheda ML, 2005, J CELL PHYSIOL, V202, P654, DOI 10.1002/jcp.20166
   Marino M, 2006, CURR GENOMICS, V7, P497, DOI 10.2174/138920206779315737
   Melnik S, 2018, CELL DISCOV, V4, DOI 10.1038/s41421-018-0033-2
   Mody MD, 2021, LANCET, V398, P2289, DOI 10.1016/S0140-6736(21)01550-6
   Morin PJ, 1999, BIOESSAYS, V21, P1021, DOI 10.1002/(SICI)1521-1878(199912)22:1<1021::AID-BIES6>3.0.CO;2-P
   Nazim UM, 2017, ONCOTARGET, V8, P26819, DOI 10.18632/oncotarget.15819
   Neganova M, 2021, CANCERS, V13, DOI 10.3390/cancers13236062
   Nuszkiewicz J, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24043283
   Okumura T, 2010, J GASTROENTEROL, V45, P1097, DOI 10.1007/s00535-010-0310-9
   Olatunde A, 2021, CANCER CELL INT, V21, DOI 10.1186/s12935-021-02202-5
   Onuma M, 2003, J BIOL CHEM, V278, P42660, DOI 10.1074/jbc.M304984200
   Osmak M, 2012, CANCER LETT, V324, P1, DOI 10.1016/j.canlet.2012.04.011
   Oura K, 2022, J HEPATOCELL CARCINO, V9, P1279, DOI 10.2147/JHC.S392051
   Pai R, 2005, BIOCHEM BIOPH RES CO, V331, P984, DOI 10.1016/j.bbrc.2005.03.236
   Park JH, 2022, GASTROENTEROLOGY, V162, P509, DOI 10.1053/j.gastro.2021.09.070
   Pati S, 2023, CANCERS, V15, DOI 10.3390/cancers15020485
   Petrelli F, 2021, EUR J CLIN INVEST, V51, DOI 10.1111/eci.13493
   Petrick JL, 2014, ANN EPIDEMIOL, V24, P160, DOI 10.1016/j.annepidem.2013.11.004
   Pisani Paola, 2008, Archives of Physiology and Biochemistry, V114, P63, DOI [10.1080/13813450801954451, 10.1080/13813450801954451 ]
   Pleus S, 2024, EXP CLIN ENDOCR DIAB, V132, P112, DOI 10.1055/a-2166-6643
   Pollak MN, 2012, CANCER DISCOV, V2, P778, DOI 10.1158/2159-8290.CD-12-0263
   Pothiwala P, 2009, METAB SYNDR RELAT D, V7, P279, DOI 10.1089/met.2008.0065
   Prall OWJ, 1998, MOL CELL BIOL, V18, P4499, DOI 10.1128/MCB.18.8.4499
   Ramteke P, 2019, CANCERS, V11, DOI 10.3390/cancers11091402
   Rattan R, 2012, J ONCOL, V2012, DOI 10.1155/2012/928127
   Rêgo DF, 2017, ONCOL LETT, V13, P554, DOI 10.3892/ol.2016.5526
   Renehan AG, 2008, LANCET, V371, P569, DOI 10.1016/S0140-6736(08)60269-X
   Rhi H., 2024, European Archives of OtoRhinoLaryngology, V282, P1443
   Rodriguez AC, 2019, HORM CANCER-US, V10, P51, DOI 10.1007/s12672-019-0358-9
   Rozengurt E, 2010, CLIN CANCER RES, V16, P2505, DOI 10.1158/1078-0432.CCR-09-2229
   Ryu TY, 2014, DIABETES METAB J, V38, P330, DOI 10.4093/dmj.2014.38.5.330
   Saini N, 2018, ACTA BIOCH BIOPH SIN, V50, P133, DOI 10.1093/abbs/gmx106
   Sánchez-Jiménez F, 2019, FRONT ONCOL, V9, DOI 10.3389/fonc.2019.00596
   Sarfstein R, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061537
   Saxena NK, 2007, CANCER RES, V67, P2497, DOI 10.1158/0008-5472.CAN-06-3075
   Schleicher E, 2022, EXP CLIN ENDOCR DIAB, V130, pS1, DOI 10.1055/a-1624-2897
   Schmandt RE, 2011, AM J OBSTET GYNECOL, V205, P518, DOI 10.1016/j.ajog.2011.05.042
   Shank JJ, 2012, GYNECOL ONCOL, V127, P390, DOI 10.1016/j.ygyno.2012.07.115
   Shen LF, 2023, ANAL CELL PATHOL, V2023, DOI 10.1155/2023/4015167
   Siegel AB, 2009, CANCER-AM CANCER SOC, V115, P5651, DOI 10.1002/cncr.24687
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Soliman PT, 2006, CANCER-AM CANCER SOC, V106, P2376, DOI 10.1002/cncr.21866
   Song CW, 2012, SCI REP-UK, V2, DOI 10.1038/srep00362
   Stattin P, 2007, DIABETES CARE, V30, P561, DOI 10.2337/dc06-0922
   Sung H, 2021, CA-CANCER J CLIN, V71, P209, DOI 10.3322/caac.21660
   Teng Y, 2010, BIOCHEM BIOPH RES CO, V392, P373, DOI 10.1016/j.bbrc.2010.01.028
   Tripathi S, 2024, CANCER REP-US, V7, DOI 10.1002/cnr2.2078
   Turati F, 2013, BRIT J CANCER, V108, P222, DOI 10.1038/bjc.2012.492
   Tworoger SS, 2007, J CLIN ENDOCR METAB, V92, P1510, DOI 10.1210/jc.2006-1975
   Tzenios N., 2023, Special Journal of the Medical Academy and Other Life Sciences, V1
   Uddin S, 2009, MOL CANCER, V8, DOI 10.1186/1476-4598-8-74
   van Staa TP, 2012, DIABETOLOGIA, V55, P654, DOI 10.1007/s00125-011-2390-3
   Vangelov B, 2024, BRIT J NUTR, V132, P599, DOI [10.1017/S0007114524003040, 10.1017/S0007114524001880]
   VanSaun MN, 2013, CLIN CANCER RES, V19, P1926, DOI 10.1158/1078-0432.CCR-12-0930
   Vaziri ND, 2006, NAT CLIN PRACT NEPHR, V2, P582, DOI 10.1038/ncpneph0283
   Veeramachaneni R, 2021, J IMMUNOTHER CANCER, V9, DOI 10.1136/jitc-2021-002773
   Vigneri P, 2009, ENDOCR-RELAT CANCER, V16, P1103, DOI 10.1677/ERC-09-0087
   Wang CH, 2017, CELL PHYSIOL BIOCHEM, V42, P729, DOI 10.1159/000477890
   Wang K, 2019, LIFE SCI, V233, DOI 10.1016/j.lfs.2019.116687
   Wang LS, 2024, JAMA NETW OPEN, V7, DOI 10.1001/jamanetworkopen.2024.21305
   Wang XF, 2020, J CANCER, V11, P583, DOI 10.7150/jca.35607
   Wei S, 2009, CANCER LETT, V276, P119, DOI 10.1016/j.canlet.2008.08.008
   Welzel TM, 2011, HEPATOLOGY, V54, P463, DOI 10.1002/hep.24397
   Wu D, 2018, NATURE, V559, P637, DOI 10.1038/s41586-018-0350-5
   Wu XY, 2019, CANCER RES, V79, P4360, DOI 10.1158/0008-5472.CAN-18-3525
   Xia B, 2020, INT J CANCER, V147, P3384, DOI 10.1002/ijc.33172
   Xie Y, 2014, ONCOL LETT, V8, P1993, DOI 10.3892/ol.2014.2466
   Xuan K, 2021, EUR J CANCER PREV, V30, P84, DOI 10.1097/CEJ.0000000000000578
   Yang TH, 2020, HEAD NECK-J SCI SPEC, V42, P653, DOI 10.1002/hed.26046
   Ye J, 2009, INT J OBESITY, V33, P54, DOI 10.1038/ijo.2008.229
   Yen YC, 2015, HEAD NECK-J SCI SPEC, V37, P1268, DOI 10.1002/hed.23743
   Yin N, 2004, CANCER RES, V64, P5870, DOI 10.1158/0008-5472.CAN-04-0655
   Yki-Jarvinen H, 2004, NEW ENGL J MED, V351, P1106, DOI 10.1056/NEJMra041001
   Yoshizaki T, 2010, J EXP CLIN CANC RES, V29, DOI 10.1186/1756-9966-29-22
   Yu FY, 2021, SIGNAL TRANSDUCT TAR, V6, DOI 10.1038/s41392-021-00701-5
   Zhang JH, 2020, ARTIF CELL NANOMED B, V48, P479, DOI 10.1080/21691401.2020.1716779
   Zhang Y, 2020, J HEMATOL ONCOL, V13, DOI 10.1186/s13045-020-00990-3
   Zhang ZM, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms232112729
   Zhao L, 2011, ANAT REC, V294, P1337, DOI 10.1002/ar.21283
   Zhong Amy, 2018, J Can Res Updates, V7, P64
   Zimmet P, 2005, REV ESP CARDIOL, V58, P1371, DOI 10.1016/S1885-5857(06)60742-1
NR 180
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1755-5930
EI 1755-5949
J9 CNS NEUROSCI THER
JI CNS Neurosci. Ther.
PD MAY
PY 2025
VL 31
IS 5
AR e70446
DI 10.1111/cns.70446
PG 24
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 2TM6F
UT WOS:001490937200001
PM 40387523
DA 2025-06-11
ER

PT J
AU DuBose, KD
   McKune, AJ
AF DuBose, Katrina D.
   McKune, Andrew J.
TI The Relationship Between Objectively Measured Physical Activity,
   Salivary Cortisol, and the Metabolic Syndrome Score in Girls
SO PEDIATRIC EXERCISE SCIENCE
LA English
DT Article
DE physical activity; salivary cortisol; metabolic syndrome; children
ID BODY-MASS INDEX; EPOCH LENGTH; SERUM CORTISOL; RISK-FACTORS; CHILDREN;
   EXERCISE; YOUTH; ADOLESCENTS; OBESITY; STRESS
AB The relationship between physical activity levels, salivary cortisol, and the metabolic syndrome (MetSyn) score was examined. Twenty-three girls (8.4 +/- 0.9 years) had a fasting blood draw, waist circumference and blood pressure measured, and wore an ActiGraph accelerometer for 5 days. Saliva samples were collected to measure cortisol levels. Previously established cut points estimated the minutes spent in moderate, vigorous, and moderate-to-vigorous physical activity. A continuous MetSyn score was created from blood pressure, waist circumference, high-density-lipoprotein (HDL), triglyceride, and glucose values. Correlation analyses examined associations between physical activity, cortisol, the MetSyn score, and its related components. Regression analysis examined the relationship between cortisol, the MetSyn score, and its related components adjusting for physical activity, percent body fat, and sexual maturity. Vigorous physical activity was positively related with 30 min post waking cortisol values. The MetSyn score was not related with cortisol values after controlling for confounders. In contrast, HDL was negatively related with 30 min post waking cortisol. Triglyceride was positively related with 30 min post waking cortisol and area under the curve. The MetSyn score and many of its components were not related to cortisol salivary levels even after adjusting for physical activity, body fat percentage, and sexual maturity.
C1 [DuBose, Katrina D.] E Carolina Univ, Dept Kinesiol, Greenville, NC 27858 USA.
   [McKune, Andrew J.] Univ KwaZulu Natal, Discipline Biokinet Exercise & Leisure Sci, Durban, South Africa.
C3 University of North Carolina; East Carolina University; University of
   Kwazulu Natal
RP DuBose, KD (corresponding author), E Carolina Univ, Dept Kinesiol, Greenville, NC 27858 USA.
EM dubosek@ecu.edu
RI McKune, Andrew/AAM-3086-2020
OI McKune, Andrew/0000-0002-5479-1544
FU Department of Kinesiology, East Carolina University
FX This work was supported by the Department of Kinesiology, East Carolina
   University.
CR Aardal-Eriksson E, 1998, CLIN CHEM LAB MED, V36, P215, DOI 10.1515/CCLM.1998.037
   Andersen LB, 2006, LANCET, V368, P299, DOI 10.1016/S0140-6736(06)69075-2
   [Anonymous], APPL BODY COMPOSITIO
   [Anonymous], VITAL HLTH STAT
   [Anonymous], ACSMS GUID EX TEST P
   [Anonymous], J DIABETES
   Biro FM, 2003, J PEDIATR-US, V142, P643, DOI 10.1067/mpd.2003.244
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   Björntorp P, 1999, ANN NY ACAD SCI, V892, P297, DOI 10.1111/j.1749-6632.1999.tb07803.x
   Brage S, 2004, DIABETES CARE, V27, P2141, DOI 10.2337/diacare.27.9.2141
   Cieslak TJ, 2003, J APPL PHYSIOL, V95, P2315, DOI 10.1152/japplphysiol.00400.2003
   DELCORRAL P, 1994, MED SCI SPORT EXER, V26, P1297
   Dencker M, 2012, J SPORT MED PHYS FIT, V52, P115
   Dubose KD, 2006, ACTA PAEDIATR, V95, P1005, DOI 10.1080/08035250600570553
   DuBose KD, 2013, J PEDIATR ENDOCR MET, V26, P841, DOI 10.1515/jpem-2012-0415
   Edwardson CL, 2010, MED SCI SPORT EXER, V42, P928, DOI 10.1249/MSS.0b013e3181c301f5
   Eisenmann JC, 2010, DIABETOL METAB SYNDR, V2, DOI 10.1186/1758-5996-2-8
   Ekelund U, 2007, DIABETOLOGIA, V50, P1832, DOI 10.1007/s00125-007-0762-5
   Ekelund U, 2006, PLOS MED, V3, P2449, DOI 10.1371/journal.pmed.0030488
   Ford ES, 2008, J PEDIATR-US, V152, P160, DOI 10.1016/j.jpeds.2007.07.056
   Ford ES, 2008, CARDIOVASC DIABETOL, V7, DOI 10.1186/1475-2840-7-35
   Fries E, 2009, INT J PSYCHOPHYSIOL, V72, P67, DOI 10.1016/j.ijpsycho.2008.03.014
   Goodman E, 2005, CIRCULATION, V111, P1970, DOI 10.1161/01.CIR.0000161957.34198.2B
   Goodman Elizabeth, 2009, J Pediatr, V155, DOI 10.1016/j.jpeds.2009.04.045
   Gozansky WS, 2005, CLIN ENDOCRINOL, V63, P336, DOI 10.1111/j.1365-2265.2005.02349.x
   Hackney AC, 1999, CLIN PHYSIOL, V19, P178
   Hershberger AM, 2004, J CLIN ENDOCR METAB, V89, P4701, DOI 10.1210/jc.2003-031144
   Hill EE, 2008, J ENDOCRINOL INVEST, V31, P587, DOI 10.1007/BF03345606
   Holmes ME, 2010, OBES REV, V11, P492, DOI 10.1111/j.1467-789X.2009.00680.x
   Holmes ME, 2008, J PHYS ACT HEALTH, V5, P294, DOI 10.1123/jpah.5.2.294
   Hsu YW, 2011, MED SCI SPORT EXER, V43, P2307, DOI 10.1249/MSS.0b013e318222020f
   Jacks DE, 2002, J STRENGTH COND RES, V16, P286, DOI 10.1519/00124278-200205000-00018
   Johnson WD, 2009, ARCH PEDIAT ADOL MED, V163, P371, DOI 10.1001/archpediatrics.2009.3
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   Kaplowitz PB, 2001, PEDIATRICS, V108, P347, DOI 10.1542/peds.108.2.347
   Karacabey K, 2009, J INT MED RES, V37, P1472, DOI 10.1177/147323000903700523
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lambert M, 2004, INT J OBESITY, V28, P833, DOI 10.1038/sj.ijo.0802694
   Martikainen S, 2013, J CLIN ENDOCR METAB, V98, pE619, DOI 10.1210/jc.2012-3745
   Mcclain JJ, 2008, MED SCI SPORT EXER, V40, P2080, DOI 10.1249/MSS.0b013e3181824d98
   McKune AJ, 2012, JEMDSA, V17, P44, DOI 10.1080/22201009.2012.10872273
   MEERAN K, 1993, BRIT J CLIN PRACT, V47, P246
   National Heart Lung and Blood Institute, 2011, Pediatrics, V128, P1
   NINDL BC, 1995, MED SCI SPORT EXER, V27, P235
   Okosun IS, 2010, J CLIN HYPERTENS, V12, P636, DOI 10.1111/j.1751-7176.2010.00338.x
   Sen Y, 2008, NEUROENDOCRINOL LETT, V29, P141
   Stone MR, 2009, INT J PEDIATR OBES, V4, P306, DOI 10.3109/17477160902846179
   STRONG JP, 1992, J AM COLL NUTR, V11, pS51
   Trost SG, 2011, MED SCI SPORT EXER, V43, P1360, DOI 10.1249/MSS.0b013e318206476e
   Wall Sarah J, 2009, Res Q Exerc Sport, V80, P739
   Weigensberg MJ, 2008, J CLIN ENDOCR METAB, V93, P1372, DOI 10.1210/jc.2007-2309
NR 51
TC 11
Z9 11
U1 1
U2 22
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 0899-8493
EI 1543-2920
J9 PEDIATR EXERC SCI
JI Pediatr. Exerc. Sci.
PD AUG
PY 2014
VL 26
IS 3
BP 221
EP 230
DI 10.1123/pes.2013-0109
PG 10
WC Pediatrics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Physiology; Sport Sciences
GA AN3UH
UT WOS:000340513700001
PM 24722755
DA 2025-06-11
ER

PT J
AU Conroy, SM
   Butler, LM
   Harvey, D
   Gold, EB
   Sternfeld, B
   Greendale, GA
   Habel, LA
AF Conroy, Shannon M.
   Butler, Lesley M.
   Harvey, Danielle
   Gold, Ellen B.
   Sternfeld, Barbara
   Greendale, Gail A.
   Habel, Laurel A.
TI Metabolic syndrome and mammographic density: the Study of Women's Health
   Across the Nation
SO INTERNATIONAL JOURNAL OF CANCER
LA English
DT Article
DE adiposity; body mass index; breast cancer risk factor; mammographic
   density; metabolic syndrome
ID HUMAN BREAST-CANCER; GROWTH-FACTOR; INSULIN-RESISTANCE; SIGNALING
   PATHWAYS; OXIDATIVE STRESS; HDL-CHOLESTEROL; RISK; ASSOCIATION;
   POPULATION; GLUCOSE
AB The metabolic syndrome (MetS) is associated with an increase in breast cancer risk. In our study, we evaluated whether the MetS was associated with an increase in percent mammographic density (MD), a breast cancer risk factor. We used linear regression and mixed models to examine the cross-sectional and longitudinal associations of the MetS and components of the MetS to percent MD in 790 premenopausal and early perimenopausal women enrolled in the Study of Women's Health Across the Nation (SWAN). In cross-sectional analyses adjusted for body mass index (BMI), modest inverse associations were observed between percent MD and the MetS [beta = -2.5, standard error (SE) = 1.9, p = 0.19], abdominal adiposity (beta = -4.8, SE = 1.9, p = 0.01) and raised glucose (beta = -3.7, SE = 2.4, p = 0.12). In longitudinal models adjusted for covariates including age and BMI, abdominal adiposity (beta = 0.34, SE = 0.17, p = 0.05) was significantly positively associated with slower annual decline in percent MD with time. In conclusion, our results do not support the hypothesis that the MetS increases breast cancer risk via a mechanism reflected by an increase in percent MD.
C1 [Conroy, Shannon M.] Univ Hawaii, Ctr Canc, Canc Epidemiol Program, Honolulu, HI 96813 USA.
   [Conroy, Shannon M.; Harvey, Danielle; Gold, Ellen B.] Univ Calif Davis, Div Epidemiol, Dept Publ Hlth Sci, Davis, CA 95616 USA.
   [Butler, Lesley M.] Colorado State Univ, Dept Environm & Radiol Hlth Sci, Ft Collins, CO 80523 USA.
   [Greendale, Gail A.] Univ Calif Los Angeles, David Geffen Sch Med, Div Geriatr, Los Angeles, CA 90095 USA.
   [Sternfeld, Barbara; Habel, Laurel A.] Kaiser Permanente Med Care Program, Div Res, Oakland, CA 94611 USA.
C3 Cancer Research Center of Hawaii; University of Hawaii System;
   University of California System; University of California Davis;
   Colorado State University System; Colorado State University Fort
   Collins; University of California System; University of California Los
   Angeles; University of California Los Angeles Medical Center; David
   Geffen School of Medicine at UCLA; Kaiser Permanente
RP Conroy, SM (corresponding author), Univ Hawaii, Ctr Canc, Canc Epidemiol Program, 1236 Lauhala St,Suite 407, Honolulu, HI 96813 USA.
EM sconroy@crch.hawaii.edu
RI Harvey, Danielle/A-5496-2017
OI Conroy, Shannon/0000-0002-6120-8169; Habel, Laurel/0000-0002-7230-587X
FU National Institutes of Health (NIH); DHHS; National Institute on Aging
   (NIA); National Institute of Nursing Research (NINR); NIH Office of
   Research on Women's Health (ORWH) [NR004061, AG012505, AG012535,
   AG012531, AG012539, AG012546, AG012553, AG012554, AG012495]; National
   Cancer Institute [R01CA89552, R25CA90956]
FX Grant sponsors: National Institutes of Health (NIH), DHHS, National
   Institute on Aging (NIA), National Institute of Nursing Research (NINR),
   NIH Office of Research on Women's Health (ORWH); Grant numbers:
   NR004061, AG012505, AG012535, AG012531, AG012539, AG012546, AG012553,
   AG012554, AG012495; Grant sponsor: National Cancer Institute; Grant
   numbers: R01CA89552, R25CA90956
CR Abdilla N, 2007, J HUM HYPERTENS, V21, P68, DOI 10.1038/sj.jhh.1002105
   Agnoli C, 2010, NUTR METAB CARDIOVAS, V20, P41, DOI 10.1016/j.numecd.2009.02.006
   [Anonymous], 2009, National health statistics reports
   Bjorge T, 2010, CANCER EPIDEM BIOMAR, V19, P1737, DOI 10.1158/1055-9965.EPI-10-0230
   Boyd NF, 1998, CANCER EPIDEM BIOMAR, V7, P1133
   BOYD NF, 1995, CANCER EPIDEM BIOMAR, V4, P727
   Boyd NF, 2002, BRIT J CANCER, V87, P876, DOI 10.1038/sj.bjc.6600537
   Boyd NF, 2006, CANCER EPIDEM BIOMAR, V15, P2086, DOI 10.1158/1055-9965.EPI-06-0345
   BROWN RS, 1993, CANCER, V72, P2979, DOI 10.1002/1097-0142(19931115)72:10<2979::AID-CNCR2820721020>3.0.CO;2-X
   BYRNE C, 1995, J NATL CANCER I, V87, P1622, DOI 10.1093/jnci/87.21.1622
   Cao RH, 2001, P NATL ACAD SCI USA, V98, P6390, DOI 10.1073/pnas.101564798
   Carroll S, 2004, SPORTS MED, V34, P371, DOI 10.2165/00007256-200434060-00004
   COGHLIN J, 1989, AM J EPIDEMIOL, V130, P696, DOI 10.1093/oxfordjournals.aje.a115391
   Cowey S, 2006, AM J PATHOL, V169, P1505, DOI 10.2353/ajpath.2006.051090
   FERRIS BG, 1978, AM REV RESPIR DIS, V118, P1
   Furberg AS, 2005, CANCER EPIDEM BIOMAR, V14, P33
   Furberg AS, 2004, J NATL CANCER I, V96, P1152, DOI 10.1093/jnci/djh216
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Habel LA, 2007, MENOPAUSE, V14, P891, DOI 10.1097/gme.0b013e318032569c
   Haffner SM, 1997, ANN NY ACAD SCI, V827, P1, DOI 10.1111/j.1749-6632.1997.tb51818.x
   Haiman CA, 2002, BREAST CANCER RES, V4, DOI 10.1186/bcr434
   Harvie M, 2003, Obes Rev, V4, P157, DOI 10.1046/j.1467-789X.2003.00108.x
   Healy LA, 2010, CLIN ONCOL-UK, V22, P281, DOI 10.1016/j.clon.2010.02.001
   Hu X, 2002, J NATL CANCER I, V94, P1704, DOI 10.1093/jnci/94.22.1704
   Huang Z, 1999, AM J EPIDEMIOL, V150, P1316, DOI 10.1093/oxfordjournals.aje.a009963
   Kabat GC, 2009, CANCER EPIDEM BIOMAR, V18, P2046, DOI 10.1158/1055-9965.EPI-09-0235
   Maiti B, 2010, BREAST CANCER RES TR, V121, P479, DOI 10.1007/s10549-009-0591-y
   Menon V, 2004, DIABETIC MED, V21, P1346, DOI 10.1111/j.1464-5491.2004.01417.x
   Muti P, 2002, CANCER EPIDEM BIOMAR, V11, P1361
   Pasanisi P, 2006, INT J CANCER, V119, P236, DOI 10.1002/ijc.21812
   Piché MÉ, 2005, AM J CARDIOL, V96, P92, DOI 10.1016/j.amjcard.2005.02.051
   Roubidoux MA, 2003, CANCER EPIDEM BIOMAR, V12, P552
   Russo A, 2008, EUR J CANCER, V44, P293, DOI 10.1016/j.ejca.2007.11.005
   Santoro N, 2005, J CLIN ENDOCR METAB, V90, P4836, DOI 10.1210/jc.2004-2063
   Sellers TA, 2007, CANCER CAUSE CONTROL, V18, P505, DOI 10.1007/s10552-007-0128-9
   Shukla A, 2009, ENDOCR-RELAT CANCER, V16, P429, DOI 10.1677/ERC-08-0240
   SOLER NG, 1984, LANCET, V1, P193
   Sowers M.F., 2000, Menopause: biology and pathobiology, P175, DOI DOI 10.1016/B978-012453790-3/50012-3
   STEINER PM, 1981, J CLIN CHEM CLIN BIO, V19, P850
   Sternfeld B, 1999, PREV MED, V28, P313, DOI 10.1006/pmed.1998.0470
   Strange KS, 2002, BREAST CANCER RES TR, V75, P203, DOI 10.1023/A:1019915101457
   Tamburrini AL, 2011, BREAST CANCER RES TR, V125, P181, DOI 10.1007/s10549-010-0927-7
   Tang XD, 2010, INT J CANCER, V126, P90, DOI 10.1002/ijc.24710
   Tseng M, 2011, INT J CANCER, V128, P418, DOI 10.1002/ijc.25338
   Ursin G, 1998, CANCER EPIDEM BIOMAR, V7, P43
   Vachon CM, 2007, CANCER EPIDEM BIOMAR, V16, P43, DOI 10.1158/1055-9965.EPI-06-0738
   Vachon CM, 2000, CANCER CAUSE CONTROL, V11, P653, DOI 10.1023/A:1008926607428
   WARNICK GR, 1978, J LIPID RES, V19, P65
   WELLINGS SR, 1978, RADIOLOGY, V129, P299, DOI 10.1148/129.2.299
NR 50
TC 20
Z9 21
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0020-7136
EI 1097-0215
J9 INT J CANCER
JI Int. J. Cancer
PD OCT 1
PY 2011
VL 129
IS 7
BP 1699
EP 1707
DI 10.1002/ijc.25790
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 798XX
UT WOS:000293246600016
PM 21105041
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Dayar, E
   Kara, E
   Yetik-Anacak, G
   Hocaoglu, N
   Bozkurt, O
   Gidener, S
   Durmus, N
AF Dayar, E.
   Kara, E.
   Yetik-Anacak, G.
   Hocaoglu, N.
   Bozkurt, O.
   Gidener, S.
   Durmus, N.
TI Do penile haemodynamics change in the presence of hydrogen sulphide
   (H2S) donor in metabolic syndrome-induced erectile
   dysfunction?
SO ANDROLOGIA
LA English
DT Article
DE erectile dysfunction; fructose; hydrogen sulphide; intracavernous
   pressure; metabolic syndrome
ID CORPUS CAVERNOSUM; PROTEIN EXPRESSION; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; RAT MODEL; RESPONSES; FRUCTOSE; BIOSYNTHESIS; RESVERATROL;
   DEFICIENCY
AB Erectile dysfunction (ED) is defined in relation to the metabolic syndrome (metS). Hydrogen sulphide (H2S), a gasotransmitter, has been revealed to get involved in hypertension, insulin secretion and regulation of vascular tone especially in erectile physiology. This study aimed to investigate the effect of H2S on metS-induced ED. Animals were divided into two groups as control and metS, which were fed with standard diet or 60% high-fructose diet for 10weeks respectively. The metS model was evaluated with biochemical analyses, waist circumference/tibia length ratio and HOMA index. Penile hemodynamic parameters were evaluated by the measurement of intracavernous pressure/mean arterial pressure ratio during cavernous nerve stimulation in the presence and absence of intracavernous injection of NaHS (100g/50l) and its control 0.9%NaCl (50l) in both groups. H2S levels were measured in penile tissues by methylene blue assay. H2S levels were significantly decreased in the penile tissues of the metS group. Decreased intracavernous pressure/mean arterial pressure ratio improved after intracavernous administration of NaHS in the metS group. These results suggest the significant role of H2S in the metS-induced erectile dysfunction that could be a new therapeutic target.
C1 [Dayar, E.; Kara, E.; Hocaoglu, N.; Gidener, S.; Durmus, N.] Dokuz Eylul Univ, Dept Pharmacol, Fac Med, Izmir, Turkey.
   [Yetik-Anacak, G.] Ege Univ, Dept Pharmacol, Fac Med, Izmir, Turkey.
   [Bozkurt, O.] Dokuz Eylul Univ, Dept Urol, Fac Med, Izmir, Turkey.
C3 Dokuz Eylul University; Ege University; Dokuz Eylul University
RP Durmus, N (corresponding author), Dokuz Eylul Univ, Dept Pharmacol, Fac Med, Izmir, Turkey.
EM nrgzdurmus@gmail.com
RI gidener, sedef/NJS-8676-2025; Yetik Anacak, Gunay/A-1418-2018; HOCAOGLU
   AKSAY, NIL/P-4614-2019; Durmus, Nergiz/KAM-1185-2024
OI Yetik Anacak, Gunay/0000-0002-7788-1657; HOCAOGLU AKSAY,
   NIL/0000-0002-7449-6809; GIDENER, SEDEF/0000-0002-5182-9789; Durmus,
   Nergiz/0000-0003-4739-9154
FU Research Foundation of Dokuz Eylul University [2014.KB.SAG.027]
FX Research Foundation of Dokuz Eylul University, Grant/Award Number:
   2014.KB.SAG.027
CR Al-Magableh MR, 2015, HYPERTENS RES, V38, P13, DOI 10.1038/hr.2014.125
   Angulo J, 2010, J SEX MED, V7, P758, DOI 10.1111/j.1743-6109.2009.01587.x
   Bal E, 2009, TOHOKU J EXP MED, V217, P239, DOI 10.1620/tjem.217.239
   Barr LA, 2014, CIRC J, V78, P2111, DOI 10.1253/circj.CJ-14-0728
   Besiroglu H, 2015, J SEX MED, V12, P1309, DOI 10.1111/jsm.12885
   Bianca RDD, 2011, NAT REV UROL, V8, P286, DOI 10.1038/nrurol.2011.45
   Boulton AJM, 2001, DIABETOLOGIA, V44, P1296, DOI 10.1007/s001250100656
   Brancaleone V, 2008, BRIT J PHARMACOL, V155, P673, DOI 10.1038/bjp.2008.296
   Briganti A, 2005, WORLD J UROL, V23, P374, DOI 10.1007/s00345-005-0022-6
   Bucci M, 2010, ARTERIOSCL THROM VAS, V30, P1998, DOI 10.1161/ATVBAHA.110.209783
   Chaudhary RK, 2016, J INT MED RES, V44, P735, DOI 10.1177/0300060515623122
   Chiou WF, 2010, BJU INT, V105, P674, DOI 10.1111/j.1464-410X.2009.08852.x
   Coletta C, 2015, MOL MED, V21, DOI 10.2119/molmed.2015.00035
   Contreras C, 2010, BRIT J PHARMACOL, V161, P350, DOI 10.1111/j.1476-5381.2010.00825.x
   d'Emmanuele diVilla Bianca R, 2009, P NATL ACAD SCI US, V106, P4513, DOI DOI 10.1073/PNAS.0807974105
   Demir O, 2010, UROL INT, V85, P112, DOI 10.1159/000296286
   DROLLER MJ, 1993, JAMA-J AM MED ASSOC, V270, P83
   Ghezzi AC, 2012, DIABETOL METAB SYNDR, V4, DOI 10.1186/1758-5996-4-16
   Jain SK, 2010, ANTIOXID REDOX SIGN, V12, P1333, DOI 10.1089/ars.2009.2956
   Jeremy JY, 2007, INT J IMPOT RES, V19, P265, DOI 10.1038/sj.ijir.3901523
   Jupiter RC, 2015, AM J PHYSIOL-HEART C, V309, pH835, DOI 10.1152/ajpheart.00293.2015
   Kaya E, 2015, J SEX MED, V12, P856, DOI 10.1111/jsm.12828
   Khitan Z, 2013, J NUTR METAB, V2013, DOI 10.1155/2013/682673
   Kim SD, 2013, ASIAN J ANDROL, V15, P395, DOI 10.1038/aja.2012.159
   Lechuga TJ, 2015, ENDOCRINOLOGY, V156, P2288, DOI 10.1210/en.2015-1086
   Liu ZH, 2014, ANDROLOGIA, V46, P487, DOI 10.1111/and.12105
   Lozano I, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0074-1
   Maas R, 2002, VASC MED, V7, P213, DOI 10.1191/1358863x02vm429ra
   Musicki B, 2015, J SEX MED, V12, P2233, DOI 10.1111/jsm.13069
   Nagai Y, 2009, EXP PHYSIOL, V94, P1016, DOI 10.1113/expphysiol.2009.048108
   Padiya R, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-53
   Papapetropoulos A, 2009, P NATL ACAD SCI USA, V106, P21972, DOI 10.1073/pnas.0908047106
   Pereira CD, 2014, ASIAN J ANDROL, V16, P631, DOI 10.4103/1008-682X.122869
   Srilatha B, 2006, EUR J PHARMACOL, V535, P280, DOI 10.1016/j.ejphar.2006.02.001
   Srilatha B, 2012, AGING MALE, V15, P153, DOI 10.3109/13685538.2012.668722
   STIPANUK MH, 1982, BIOCHEM J, V206, P267, DOI 10.1042/bj2060267
   Tappy L, 2010, NUTRITION, V26, P1044, DOI 10.1016/j.nut.2010.02.014
   Vignozzi L, 2011, J SEX MED, V8, P57, DOI 10.1111/j.1743-6109.2010.02073.x
   Wingard C, 2007, J SEX MED, V4, P348, DOI 10.1111/j.1743-6109.2007.00439.x
   Wu LY, 2009, LAB INVEST, V89, P59, DOI 10.1038/labinvest.2008.109
   Yang GD, 2008, SCIENCE, V322, P587, DOI 10.1126/science.1162667
   Yetik-Anacak G, 2015, BRIT J PHARMACOL, V172, P1434, DOI 10.1111/bph.12700
   Yetik-Anacak G, 2016, VASC PHARMACOL, V87, P76, DOI 10.1016/j.vph.2016.08.003
   Yetik-Anacak G, 2016, PHARMACOL RES, V113, P38, DOI 10.1016/j.phrs.2016.08.015
   Yetik-Anacak G, 2015, J SEX MED, V12, P2004, DOI 10.1111/jsm.12993
   Yu XH, 2014, CLIN CHIM ACTA, V437, P78, DOI 10.1016/j.cca.2014.07.012
   Yusuf M, 2005, BIOCHEM BIOPH RES CO, V333, P1146, DOI 10.1016/j.bbrc.2005.06.021
   Zhang Y, 2016, J SEX MED, V13, P350, DOI 10.1016/j.jsxm.2016.01.002
NR 48
TC 12
Z9 14
U1 0
U2 26
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-4569
EI 1439-0272
J9 ANDROLOGIA
JI Andrologia
PD APR
PY 2018
VL 50
IS 3
AR e12885
DI 10.1111/and.12885
PG 7
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FY0HB
UT WOS:000426490200003
PM 28901567
OA gold
DA 2025-06-11
ER

PT J
AU Butcher, JT
   Goodwill, AG
   Stanley, SC
   Frisbee, JC
AF Butcher, Joshua T.
   Goodwill, Adam G.
   Stanley, Shyla C.
   Frisbee, Jefferson C.
TI Differential Impact of Dilator Stimuli on Increased Myogenic Activation
   of Cerebral and Skeletal Muscle Resistance Arterioles in Obese Zucker
   Rats
SO MICROCIRCULATION
LA English
DT Article
DE regulation of vascular tone; rodent models of metabolic syndrome;
   peripheral resistance; microcirculation
ID METABOLIC SYNDROME; OXYGEN-TENSION; FATTY RAT; EPIDEMIOLOGY;
   CONSTRICTION; INTEGRATION; DEFINITION; RESPONSES; PERFUSION; INSULIN
AB ObjectiveTo use the OZR model of the metabolic syndrome to determine the impact of dilator stimuli on MA of GA and MCA. We tested the hypothesis that increased oxidant stress and TxA(2) exacerbate MA, and prevent its blunting with dilator stimuli, in OZR.
   MethodsGA/MCA from OZR and LZR was pressurized ex vivo. MA was determined under control conditions and following challenge with acetylcholine, hypoxia, and adenosine. Responses were also evaluated after pre-treatment with TEMPOL (antioxidant) and SQ-29548 (PGH(2)/TxA(2) receptor antagonist).
   ResultsMA was increased (and dilator responses decreased) in GA/MCA from OZR, dependent on the endothelium and ROS. In GA, the impact of ROS on MA and dilator effects was largely via TxA(2), while in MCA, this appeared was more dependent on NO bioavailability. Intrinsic responses of GA/MCA to carbacyclin, U46619, and NO donors were similar between strains.
   ConclusionsA developing ROS-based endothelial dysfunction in MCA and GA of OZR contributes to an enhanced MA of these vessels. Although treatment of GA/MCA with TEMPOL attenuates MA in OZR, the mechanistic contributors to altered MA, distal to ROS, differ between the two resistance vessels.
C1 [Butcher, Joshua T.; Goodwill, Adam G.; Stanley, Shyla C.; Frisbee, Jefferson C.] W Virginia Univ, Sch Med, Dept Physiol & Pharmacol, Morgantown, WV 26506 USA.
   [Butcher, Joshua T.; Goodwill, Adam G.; Stanley, Shyla C.; Frisbee, Jefferson C.] W Virginia Univ, Sch Med, Ctr Cardiovasc & Resp Sci, Morgantown, WV 26506 USA.
C3 West Virginia University; West Virginia University
RP Frisbee, JC (corresponding author), W Virginia Univ, Hlth Sci Ctr, Ctr Cardiovasc & Resp Sci, Dept Physiol & Pharmacol, 3152 HSN,1 Med Ctr Dr, Morgantown, WV 26506 USA.
EM jefrisbee@hsc.wvu.edu
RI Butcher, Joshua/ABH-7212-2022; Goodwill, Adam/N-4889-2016
OI Goodwill, Adam/0000-0003-3701-3713; Frisbee,
   Jefferson/0000-0003-2751-0599; Butcher, Joshua/0000-0002-7341-1949
FU National Institutes of Health [NIH T32 HL 90610, RR 2865AR, IDeA P20 GM
   103434]; American Heart Association [AHA EIA 0740129N]
FX This study was supported by grants from the National Institutes of
   Health (NIH T32 HL 90610, RR 2865AR and IDeA P20 GM 103434), the
   American Heart Association (AHA EIA 0740129N). The authors express their
   gratitude for the expert technical assistance from Ms. Milinda James
   from the Department of Physiology and Pharmacology at West Virginia
   University.
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   AMY RM, 1988, ATHEROSCLEROSIS, V69, P199, DOI 10.1016/0021-9150(88)90015-9
   [Anonymous], NATL HLTH STAT REPOR
   BRAY GA, 1977, FED PROC, V36, P148
   Bray GA, 2006, ENDOCRINE, V29, P109, DOI 10.1385/ENDO:29:1:109
   Butcher JT, 2012, JOVE-J VIS EXP, DOI 10.3791/3674
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Frisbee JC, 2005, AM J PHYSIOL-REG I, V289, pR307, DOI 10.1152/ajpregu.00114.2005
   Frisbee JC, 2002, AM J PHYSIOL-REG I, V283, pR309, DOI 10.1152/ajpregu.00741.2001
   Frisbee JC, 2002, AM J PHYSIOL-HEART C, V283, pH2160, DOI 10.1152/ajpheart.00379.2002
   Frisbee JC, 2001, MICROVASC RES, V62, P271, DOI 10.1006/mvre.2001.2341
   Frisbee JC, 2001, AM J PHYSIOL-HEART C, V281, pH1568, DOI 10.1152/ajpheart.2001.281.4.H1568
   Frisbee JC, 2011, EXP PHYSIOL, V96, P369, DOI 10.1113/expphysiol.2010.055418
   Frisbee JC, 2009, AM J PHYSIOL-REG I, V296, pR1771, DOI 10.1152/ajpregu.00096.2009
   Goodwill AG, 2008, AM J PHYSIOL-HEART C, V295, pH1522, DOI 10.1152/ajpheart.00596.2008
   Gorter PM, 2004, ATHEROSCLEROSIS, V173, P363, DOI 10.1016/j.atherosclerosis.2003.12.033
   KURTZ TW, 1989, HYPERTENSION, V13, P896, DOI 10.1161/01.HYP.13.6.896
   Lenda DM, 2000, AM J PHYSIOL-HEART C, V279, pH7, DOI 10.1152/ajpheart.2000.279.1.H7
   Lombard JH, 1999, AM J PHYSIOL-HEART C, V276, pH509, DOI 10.1152/ajpheart.1999.276.2.H509
   Lusis AJ, 2008, NAT REV GENET, V9, P819, DOI 10.1038/nrg2468
   MESSINA EJ, 1994, MICROVASC RES, V48, P151, DOI 10.1006/mvre.1994.1046
   Miranda PJ, 2005, AM HEART J, V149, P33, DOI 10.1016/j.ahj.2004.07.013
   Osmond JM, 2009, HYPERTENSION, V53, P381, DOI 10.1161/HYPERTENSIONAHA.108.124149
   Phillips SA, 2005, AM J PHYSIOL-REG I, V288, pR522, DOI 10.1152/ajpregu.00655.2004
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Stepp DW, 2002, AM J PHYSIOL-HEART C, V282, pH816, DOI 10.1152/ajpheart.00695.2001
   Ungvari Z, 2001, AM J PHYSIOL-HEART C, V281, pH606, DOI 10.1152/ajpheart.2001.281.2.H606
   Xiang LH, 2006, AM J PHYSIOL-REG I, V290, pR134, DOI 10.1152/ajpregu.00295.2005
   ZUCKER LM, 1972, ENDOCRINOLOGY, V90, P1320, DOI 10.1210/endo-90-5-1320
NR 29
TC 16
Z9 21
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1073-9688
EI 1549-8719
J9 MICROCIRCULATION
JI Microcirculation
PD OCT
PY 2013
VL 20
IS 7
BP 579
EP 589
DI 10.1111/micc.12056
PG 11
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 234BA
UT WOS:000325612800001
PM 23510266
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Abdel-Qader, DH
   Albassam, A
   Taybeh, E
   Al Mazrouei, N
   Meer, SMA
   Al-Kubaisi, KA
   Ibrahim, R
   Elnour, AA
   Ibrahim, OM
   Aburuz, S
AF Abdel-Qader, Derar H.
   Albassam, Abdullah
   Taybeh, Esra'
   Al Mazrouei, Nadia
   Meer, Sara Murad Albarkat
   Al-Kubaisi, Khalid Awad
   Ibrahim, Rana
   Elnour, Asim Ahmed
   Mohamed Ibrahim, Osama
   Aburuz, Salah
TI Lipid and Glucose Profile across Different Mental Disorders
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE schizophrenia; unipolar depression; bipolar disorder; bipolar mania;
   bipolar depression; lipid and glucose levels
ID METABOLIC SYNDROME; SCHIZOPHRENIA; DEPRESSION; PREVALENCE;
   ANTIPSYCHOTICS; ADULTS; HEALTH
AB Objectives: Schizophrenia, unipolar depression, bipolar disorder, bipolar mania, and bipolar depression are a few of the severe psychiatric diseases that affect millions of individuals and their overall life quality. This study aimed to look at differences in TGA, TC, HDL, LDL, and FPG levels in people who were going through acute episodes of listed diseases. Materials and methods: A cross-sectional prospective study was carried out in Jordan between January and November of 2023, involving all patients with the aforementioned diseases who attended three psychiatric clinics. This study encompassed results from 1187 patients (women N = 675, 56.87%) who were classified into the following ranges: <25, 25-45, 45-65, and >65. Results: The average level of LDL was the highest in bipolar depression (112.442 +/- 36.178 mg/dL) and the lowest in bipolar mania (111.25 +/- 33.14 mg/dL). The average level of HDL was the highest in schizophrenia (58.755 +/- 16.198 mg/dL) and the lowest in bipolar depression (45.584 +/- 12.128 mg/dL). Both average levels of TC and TGA were the highest in patients with bipolar depression (188.403 +/- 37.396 mg/dL and 149.685 +/- 96.951 mg/dL, respectively) and the lowest in bipolar mania (164.790 +/- 40.488 mg/dL and 100.679 +/- 54.337 mg/dL, respectively). The average level of FPG was the highest in unipolar depression (94.00 +/- 21.453 mg/dL) and the lowest in bipolar mania (89.492 +/- 14.700 mg/dL). Conclusions: The results confirmed that lipid and glucose abnormalities were more common in people with schizophrenia and mood disorders (unipolar and bipolar).
C1 [Abdel-Qader, Derar H.] Univ Petra, Fac Pharm & Med Sci, Amman 11196, Jordan.
   [Albassam, Abdullah] Kuwait Univ, Fac Pharm, Dept Pharm Practice, Kuwait 12037, Kuwait.
   [Taybeh, Esra'] Isra Univ, Sch Pharm, Dept Appl Pharmaceut Sci, Amman 11622, Jordan.
   [Al Mazrouei, Nadia; Meer, Sara Murad Albarkat; Al-Kubaisi, Khalid Awad; Ibrahim, Rana] Univ Sharjah, Coll Pharm, Dept Pharm Practice & Pharmacotherapeut, Sharjah, U Arab Emirates.
   [Elnour, Asim Ahmed] Al Ain Univ, Coll Pharm, Abu Dhabi, U Arab Emirates.
   [Elnour, Asim Ahmed] Al Ain Univ, AAU Hlth & Biomed Res Ctr, Abu Dhabi 112612, U Arab Emirates.
   [Mohamed Ibrahim, Osama] New Giza Univ, Sch Pharm, Dept Clin Pharm, Giza 3296121, Egypt.
   [Aburuz, Salah] United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pharmacol & Therapeut, Al Ain 15551, U Arab Emirates.
C3 Petra University; Kuwait University; Isra University; University of
   Sharjah; Newgiza University (NGU); United Arab Emirates University
RP Aburuz, S (corresponding author), United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pharmacol & Therapeut, Al Ain 15551, U Arab Emirates.
EM d.balawi@igec.com.au; albassam@hsc.edu.kw; esra.taybeh@iu.edu.jo;
   nalmazrouei@sharjah.ac.ae; smeer@sharjah.ac.ae;
   kalkubaissi@sharjah.ac.ae; ribrahim@sharjah.ac.ae; asim.ahmed@aau.ac.ae;
   osama.hussein@ngu.edu.eg; saburuz@uaeu.ac.ae
RI aburuz, salah/P-4293-2018; Kubaissi, Khalid/GPG-0996-2022; Elnour,
   Asim/ABI-6308-2020; Ibrahim, Omer/R-5485-2018
OI Taybeh, Esra'/0000-0001-7493-7865; Ibrahim, Rana/0000-0002-9104-3852;
   Elnour, Asim/0000-0002-4143-7810; Abdel-Qader, Derar
   H./0000-0003-2576-4464
FU British Council Jordan
FX The authors thank all participants who took part in this study and all
   sub-investigators, study coordinators, and site staff who contributed to
   the conduct of this study.
CR Alexander CM, 2003, DIABETES, V52, P1210, DOI 10.2337/diabetes.52.5.1210
   De Hert MA, 2006, SCHIZOPHR RES, V83, P87, DOI 10.1016/j.schres.2005.12.855
   de Leon J, 2007, SCHIZOPHR RES, V92, P95, DOI 10.1016/j.schres.2007.01.015
   Goff DC, 2005, SCHIZOPHR RES, V80, P45, DOI 10.1016/j.schres.2005.08.010
   Grundy SM, 2019, J AM COLL CARDIOL, V73, P3168, DOI [10.1016/j.jacc.2018.11.002, 10.1161/CIR.0000000000000625, 10.1016/j.jacc.2018.11.003]
   Heiberg IH, 2019, ACTA PSYCHIAT SCAND, V139, P558, DOI 10.1111/acps.13017
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Li ZZ, 2021, INT J NEUROPSYCHOPH, V24, P798, DOI 10.1093/ijnp/pyab038
   Mozaffarian D, 2008, ARCH INTERN MED, V168, P969, DOI 10.1001/archinte.168.9.969
   Nadalin Sergej, 2023, Archives of Psychiatry Research, V59, P241, DOI 10.20471/dec.2023.59.02.07
   Richter N, 2010, EUR ARCH PSY CLIN N, V260, P41, DOI 10.1007/s00406-009-0013-5
   Sicras-Mainar A, 2008, EUR PSYCHIAT, V23, P100, DOI 10.1016/j.eurpsy.2007.07.005
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
   Wainberg ML, 2017, CURR PSYCHIAT REP, V19, DOI 10.1007/s11920-017-0780-z
   World Health Organization, 2017, WHOMSDMER20172
   Wysokinski A, 2015, DIABETES METAB SYND, V9, P168, DOI 10.1016/j.dsx.2015.04.004
   Wysokinski A, 2012, PSYCHIAT DANUB, V24, P314
NR 17
TC 0
Z9 0
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAY
PY 2024
VL 13
IS 9
AR 2499
DI 10.3390/jcm13092499
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA QJ8Y1
UT WOS:001220610100001
PM 38731028
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zainal, NH
   Newman, MG
AF Zainal, Nur Hani
   Newman, Michelle G.
TI Prospective network analysis of proinflammatory proteins, lipid markers,
   and depression components in midlife community women
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Cross-lagged; depression; endocrine; immune; inflammation;
   interpersonal; network analysis; scar theory; vulnerability theory
ID PROSPECTIVE ASSOCIATIONS; FUNCTIONAL CONNECTIVITY; METABOLIC SYNDROME;
   SEX-DIFFERENCES; INFLAMMATION; SYMPTOMS; METAANALYSIS; RISK; HEALTH;
   LIFE
AB Background Vulnerability theories propose that suboptimal levels of lipid markers and proinflammatory proteins predict future heightened depression. Scar models posit the reverse association. However, most studies that tested relationships between non-specific immune/endocrine markers and depression did not separate temporal inferences between people and within-person and how different immunometabolism markers related to unique depression symptoms. We thus used cross-lagged prospective network analyses (CLPN) to investigate this topic. Methods Community midlife women (n = 2224) completed the Center for Epidemiologic Studies-Depression scale and provided biomarker samples across five time-points spanning 9 years. CLPN identified significant relations (edges) among components (nodes) of depression (depressed mood, somatic symptoms, interpersonal issues), lipid markers [insulin, fasting glucose, triglycerides, low-density lipoprotein-cholesterol (LDL), high-density lipoprotein-cholesterol (HDL)], and proinflammatory proteins [C-reactive protein (CRP), fibrinogen], within and across time-points. All models adjusted for age, estradiol, follicle-stimulating hormone, and menopausal status. Results In within-person temporal networks, higher CRP and HDL predicted all three depression components (d = 0.131-2.112). Increased LDL preceded higher depressed mood and interpersonal issues (v. somatic symptoms) (d = 0.251-0.327). Elevated triglycerides predicted more somatic symptoms (v. depressed mood and interpersonal problems) (d = 0.131). More interpersonal problems forecasted elevated fibrinogen and LDL levels (d = 0.129-0.331), and stronger somatic symptoms preceded higher fibrinogen levels (d = 0.188). Conclusions Results supported both vulnerability and scar models. Long-term dysregulated immunometabolism systems, social disengagement, and related patterns are possible mechanistic accounts. Cognitive-behavioral therapies that optimize nutrition and physical activity may effectively target depression.
C1 [Zainal, Nur Hani] Harvard Med Sch, Dept Hlth Care Policy, Boston, MA 02115 USA.
   [Newman, Michelle G.] Penn State Univ, Dept Psychol, State Coll, PA 16801 USA.
C3 Harvard University; Harvard Medical School; Pennsylvania Commonwealth
   System of Higher Education (PCSHE); Pennsylvania State University;
   Pennsylvania State University - University Park
RP Newman, MG (corresponding author), Penn State Univ, Dept Psychol, State Coll, PA 16801 USA.
EM mgn1@psu.edu
RI Newman, Michelle G./I-4370-2013
OI Newman, Michelle G./0000-0003-0873-1409
FU National Institute of Mental Health [R01MH115128] Funding Source: NIH
   RePORTER
CR Abenavoli L, 2018, EXPERT REV GASTROENT, V12, P873, DOI 10.1080/17474124.2018.1503947
   Betz LT, 2020, NPJ SCHIZOPHR, V6, DOI 10.1038/s41537-020-00129-w
   Beydoun MA, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.4
   Blanchard MA, 2023, BEHAV RES METHODS, V55, P767, DOI 10.3758/s13428-022-01839-y
   Borsboom D, 2021, NAT REV METHOD PRIME, V1, DOI 10.1038/s43586-021-00055-w
   Castanon N, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00074
   Cecconello C., 2022, DIET INFLAMMATION HL, V1, P113, DOI [10.1016/b978-0-12-822130-3.00018-1, DOI 10.1016/B978-0-12-822130-3.00018-1]
   Chen SG, 2016, ENDOCRINE, V53, P35, DOI 10.1007/s12020-016-0869-x
   Coccurello R, 2019, BEHAV BRAIN RES, V372, DOI 10.1016/j.bbr.2019.112041
   Colasanto M, 2020, J AFFECT DISORDERS, V277, P940, DOI 10.1016/j.jad.2020.09.025
   Cosco TD, 2017, J NURS MEAS, V25, P476, DOI 10.1891/1061-3749.25.3.476
   Costenbader E, 2003, SOC NETWORKS, V25, P283, DOI 10.1016/S0378-8733(03)00012-1
   Dantzer R., 2021, Immuno-Psychiatry: Facts and Prospects, P259, DOI [10.1007/978-3-030-71229-7_16, DOI 10.1007/978-3-030-71229-7_16]
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   Das A, 2020, J AGING HEALTH, V32, P892, DOI 10.1177/0898264319862419
   Dedoncker J, 2021, NEUROSCI BIOBEHAV R, V125, P1, DOI 10.1016/j.neubiorev.2021.02.010
   Demarest TG, 2015, J BIOENERG BIOMEMBR, V47, P173, DOI 10.1007/s10863-014-9583-7
   Dias JP, 2020, PSYCHONEUROENDOCRINO, V119, DOI 10.1016/j.psyneuen.2020.104698
   Duivis HE, 2011, AM J PSYCHIAT, V168, P913, DOI 10.1176/appi.ajp.2011.10081163
   Dunlap WP, 1996, PSYCHOL METHODS, V1, P170, DOI 10.1037/1082-989X.1.2.170
   El Khoudary SR, 2016, J CLIN ENDOCR METAB, V101, P3419, DOI 10.1210/jc.2016-2144
   Ellins EA, 2017, BRAIN BEHAV IMMUN, V60, P233, DOI 10.1016/j.bbi.2016.10.017
   Epskamp S, 2020, PSYCHOMETRIKA, V85, P206, DOI 10.1007/s11336-020-09697-3
   Epskamp S, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0179891
   Epskamp S, 2018, BEHAV RES METHODS, V50, P195, DOI 10.3758/s13428-017-0862-1
   Epskamp S, 2012, J STAT SOFTW, V48, P1, DOI 10.18637/jss.v048.i04
   Falconi AM, 2016, MENOPAUSE, V23, P518, DOI 10.1097/GME.0000000000000579
   Felger JC, 2016, MOL PSYCHIATR, V21, P1358, DOI 10.1038/mp.2015.168
   Felger JC, 2020, MOL PSYCHIATR, V25, P1301, DOI 10.1038/s41380-018-0096-3
   Felger JC, 2018, CURR NEUROPHARMACOL, V16, P533, DOI 10.2174/1570159X15666171123201142
   Feng XQ, 2017, BMJ OPEN DIAB RES CA, V5, DOI 10.1136/bmjdrc-2016-000198
   Fried EI, 2020, PSYCHOL MED, V50, P2682, DOI 10.1017/S0033291719002770
   Fried EI, 2018, CLIN PSYCHOL SCI, V6, P335, DOI 10.1177/2167702617745092
   FRUCHTERMAN TMJ, 1991, SOFTWARE PRACT EXPER, V21, P1129, DOI 10.1002/spe.4380211102
   Goldsmith DR, 2020, BRAIN BEHAV IMMUN, V88, P193, DOI 10.1016/j.bbi.2020.05.013
   Gouin JP, 2020, PSYCHONEUROENDOCRINO, V112, DOI 10.1016/j.psyneuen.2019.104509
   Greendale GA, 2010, AM J EPIDEMIOL, V171, P1214, DOI 10.1093/aje/kwq067
   Hamer JA, 2019, EXP NEUROL, V315, P1, DOI 10.1016/j.expneurol.2019.01.016
   Hamer M, 2012, MOL PSYCHIATR, V17, P940, DOI 10.1038/mp.2012.30
   Haroon E, 2012, NEUROPSYCHOPHARMACOL, V37, P137, DOI 10.1038/npp.2011.205
   Hiles SA, 2016, DEPRESS ANXIETY, V33, P754, DOI 10.1002/da.22512
   Hu LT, 1999, STRUCT EQU MODELING, V6, P1, DOI 10.1080/10705519909540118
   Hua R, 2021, SCI BULL, V66, P1684, DOI 10.1016/j.scib.2021.02.018
   Ignácio ZM, 2019, MOL NEUROBIOL, V56, P8323, DOI 10.1007/s12035-019-01670-1
   Iob E, 2020, MOL PSYCHIATR, V25, P1130, DOI 10.1038/s41380-019-0501-6
   Irwin MR, 2014, SLEEP, V37, P1543, DOI 10.5665/sleep.4008
   Isvoranu AM, 2023, PSYCHOL METHODS, V28, P925, DOI 10.1037/met0000439
   Jeuring HW, 2018, PSYCHOL MED, V48, P1824, DOI 10.1017/S0033291717003324
   Jia QF, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-77782-9
   Johansson-Persson A, 2014, EUR J NUTR, V53, P39, DOI 10.1007/s00394-013-0496-8
   Kappelmann N, 2021, BRAIN BEHAV IMMUN, V95, P256, DOI 10.1016/j.bbi.2021.03.024
   Kelley-Hedgepeth A, 2008, CLIN CHEM, V54, P1027, DOI 10.1373/clinchem.2007.098996
   Khandaker GM, 2020, MOL PSYCHIATR, V25, P1477, DOI 10.1038/s41380-019-0395-3
   Konsman JP, 2019, PHARMACEUTICALS-BASE, V12, DOI 10.3390/ph12010029
   Kucukgoncu S, 2019, EARLY INTERV PSYCHIA, V13, P1021, DOI 10.1111/eip.12749
   Lafitte M, 2015, BMC CARDIOVASC DISOR, V15, DOI 10.1186/s12872-015-0015-3
   Lamers F, 2013, MOL PSYCHIATR, V18, P692, DOI 10.1038/mp.2012.144
   Lamers F, 2020, BRAIN BEHAV IMMUN, V88, P174, DOI 10.1016/j.bbi.2020.04.002
   Lamers F, 2019, BIOL PSYCHIAT, V85, P829, DOI 10.1016/j.biopsych.2018.12.020
   Leon BM, 2015, WORLD J DIABETES, V6, P1246, DOI 10.4239/wjd.v6.i13.1246
   Li C, 2017, J PSYCHOSOM RES, V95, P44, DOI 10.1016/j.jpsychores.2017.02.006
   Mac Giollabhui N, 2021, MOL PSYCHIATR, V26, P3302, DOI 10.1038/s41380-020-00867-4
   MacLeod CM, 1941, J EXP MED, V73, P183, DOI 10.1084/jem.73.2.183
   März W, 2017, CLIN RES CARDIOL, V106, P663, DOI 10.1007/s00392-017-1106-1
   Majd M, 2020, FRONT NEUROENDOCRIN, V56, DOI 10.1016/j.yfrne.2019.100800
   Mansur RB, 2015, NEUROSCI BIOBEHAV R, V52, P89, DOI 10.1016/j.neubiorev.2014.12.017
   McClure CK, 2014, EXP GERONTOL, V49, P19, DOI 10.1016/j.exger.2013.10.016
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Michels N, 2021, CRIT REV ONCOL HEMAT, V157, DOI 10.1016/j.critrevonc.2020.103177
   Moriarity DP, 2021, BRAIN BEHAV IMMUN, V93, P35, DOI 10.1016/j.bbi.2020.12.005
   Moriarity DP, 2021, BRAIN BEHAV IMMUN, V91, P393, DOI 10.1016/j.bbi.2020.10.020
   MYERS GL, 1989, CLIN LAB MED, V9, P105, DOI 10.1016/S0272-2712(18)30645-0
   Nam SM, 2021, J MED INTERNET RES, V23, DOI 10.2196/27344
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Peirce JM, 2019, J NEUROSCI RES, V97, P1223, DOI 10.1002/jnr.24476
   Penninx BWJH, 2017, NEUROSCI BIOBEHAV R, V74, P277, DOI 10.1016/j.neubiorev.2016.07.003
   Persons JE, 2016, J AFFECT DISORDERS, V206, P55, DOI 10.1016/j.jad.2016.07.033
   Raats M. M., 1992, Food Quality and Preference, V3, P89, DOI 10.1016/0950-3293(91)90028-D
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Raison CL, 2018, BRAIN BEHAV IMMUN, V73, P1, DOI 10.1016/j.bbi.2018.06.008
   Renna ME, 2020, PSYCHONEUROENDOCRINO, V121, DOI 10.1016/j.psyneuen.2020.104866
   Revicki DA, 2012, J AFFECT DISORDERS, V140, P103, DOI 10.1016/j.jad.2011.11.014
   Roefs A, 2022, BEHAV RES THER, V153, DOI 10.1016/j.brat.2022.104096
   Rosenthal R., 1994, The Handbook of Research Synthesis, V621, P231
   Rotella F, 2013, DIABETES RES CLIN PR, V99, P98, DOI 10.1016/j.diabres.2012.11.022
   Shimamoto A, 2017, SCHIZOPHR RES, V187, P38, DOI 10.1016/j.schres.2017.02.025
   Shimanoe C, 2018, STRESS, V21, P237, DOI 10.1080/10253890.2018.1435638
   Shin JY, 2008, ANN BEHAV MED, V36, P33, DOI 10.1007/s12160-008-9045-8
   Shomaker LB, 2017, DEPRESS ANXIETY, V34, P866, DOI 10.1002/da.22617
   Simpson CA, 2021, CLIN PSYCHOL REV, V83, DOI 10.1016/j.cpr.2020.101943
   Sin NL, 2015, BRAIN BEHAV IMMUN, V43, P130, DOI 10.1016/j.bbi.2014.07.015
   Sivertsen H, 2015, DEMENT GERIATR COGN, V40, P311, DOI 10.1159/000437299
   Smith KJ, 2020, NEUROSCI BIOBEHAV R, V112, P519, DOI 10.1016/j.neubiorev.2020.02.002
   Speyer LG, 2022, J PSYCHOPATHOL CLIN, V131, P162, DOI 10.1037/abn0000714
   Suvarna B, 2020, NEUROSCI BIOBEHAV R, V108, P694, DOI 10.1016/j.neubiorev.2019.12.020
   Tanner-Smith EE, 2016, J DEV LIFE-COURSE CR, V2, P85, DOI 10.1007/s40865-016-0026-5
   Thayer JF, 2009, J INTERN MED, V265, P439, DOI 10.1111/j.1365-2796.2008.02023.x
   Torres-Platas SG, 2014, BRAIN BEHAV IMMUN, V42, P50, DOI 10.1016/j.bbi.2014.05.007
   Valkanova V, 2013, J AFFECT DISORDERS, V150, P736, DOI 10.1016/j.jad.2013.06.004
   Vingeliene S, 2019, PSYCHONEUROENDOCRINO, V110, DOI 10.1016/j.psyneuen.2019.104421
   Von Känel R, 2009, PSYCHOPHYSIOLOGY, V46, P473, DOI 10.1111/j.1469-8986.2009.00788.x
   Walker E, 2019, BRAIN BEHAV IMMUN, V82, P224, DOI 10.1016/j.bbi.2019.08.189
   Walker JL, 2021, PSYCHOL HEALTH, V36, P967, DOI 10.1080/08870446.2020.1805450
   WARNICK GR, 1978, J LIPID RES, V19, P65
   Watson KT, 2021, AM J PSYCHIAT, V178, P914, DOI 10.1176/appi.ajp.2021.20101479
   Wiebe DJ, 2016, AM PSYCHOL, V71, P526, DOI 10.1037/a0040355
   Williams DR, 2020, BRIT J MATH STAT PSY, V73, P187, DOI 10.1111/bmsp.12173
   Wright AGC, 2020, ANNU REV CLIN PSYCHO, V16, P49, DOI 10.1146/annurev-clinpsy-102419-125032
   Xu L, 2021, J AFFECT DISORDERS, V291, P154, DOI 10.1016/j.jad.2021.05.011
   Zainal NH, 2022, PSYCHOL MED, V52, P3625, DOI 10.1017/S0033291721000398
   Zainal NH, 2022, J AFFECT DISORDERS, V296, P465, DOI 10.1016/j.jad.2021.08.077
   Zainal NH, 2021, J ABNORM PSYCHOL, V130, P829, DOI 10.1037/abn0000716
   Zainal NH, 2021, DEPRESS ANXIETY, V38, P146, DOI 10.1002/da.23093
   Zhang SF, 2022, J PSYCHIATR RES, V150, P300, DOI 10.1016/j.jpsychires.2022.04.002
NR 114
TC 18
Z9 19
U1 3
U2 37
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD AUG
PY 2023
VL 53
IS 11
BP 5267
EP 5278
AR PII S003329172200232X
DI 10.1017/S003329172200232X
EA AUG 2022
PG 12
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA Q6SY3
UT WOS:000836001300001
PM 35924730
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Adarthaiya, S
   Sehgal, A
AF Adarthaiya, Saikrupa
   Sehgal, Amit
TI Moringa oleifera Lam. as a potential plant for alleviation of the
   metabolic syndrome-A narrative review based on in vivo and clinical
   studies
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE dyslipidaemia; hyperglycaemia; hypertension; metabolic syndrome;
   moringa; obesity
ID IMPROVES GLUCOSE-TOLERANCE; AQUEOUS LEAF EXTRACT; DIET-INDUCED OBESITY;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; BLOOD-PRESSURE; SEED EXTRACT;
   TOXICOLOGICAL EVALUATION; ANTIOXIDANT ACTIVITY; GLUT4 TRANSLOCATION
AB The metabolic syndrome (MetS) refers to the co-occurrence of risk factors, including hyperglycaemia, increased body weight, hypertension and dyslipidemia, which eventually lead to diabetes and cardiovascular disease, a common health problem worldwide. Recently, there has been an increasing interest in the use of plant-based products for the management of MetS, because of their less detrimental and more beneficial effects. Moringa oleifera (Moringaceae), commonly known as drumstick, is cultivated worldwide for its nutritional and medicinal properties. This review focuses on the in vivo and human studies concerning the potential of M. oleifera in the alleviation of MetS and its comorbidities. The search for relevant articles was carried out in PubMed and Google Scholar databases. Randomised controlled and clinical trials from the PubMed database were included in this review. The results suggested that the administration of M. oleifera, in vivo, shows clear signs of improvement in MetS indices. Despite fewer human studies, the existing data documented convincing results that uphold the potential of M. oleifera against MetS. Therefore, future research discussing the probable mechanism of action is much needed which could further assure the usage of M. oleifera in the treatment regimen of MetS.
C1 [Adarthaiya, Saikrupa; Sehgal, Amit] Lovely Profess Univ, Sch Bioengn & Biosci, Dept Zool, Phagwara, India.
   [Sehgal, Amit] Lovely Profess Univ, Sch Bioengn & Biosci, Dept Zool, Phagwara 144411, Punjab, India.
C3 Lovely Professional University; Lovely Professional University
RP Sehgal, A (corresponding author), Lovely Profess Univ, Sch Bioengn & Biosci, Dept Zool, Phagwara 144411, Punjab, India.
EM sehgalamitres@gmail.com
OI Adarthaiya, Saikrupa/0009-0009-1029-9935
CR Acuram LK, 2019, COGENT BIOL, V5, DOI 10.1080/23312025.2019.1596526
   Adedapo AA, 2009, J MED PLANTS RES, V3, P586
   Adedapo AA, 2020, SCI AFR, V10, DOI 10.1016/j.sciaf.2020.e00619
   Adefegha SA, 2019, PHARMANUTRITION, V9, DOI 10.1016/j.phanu.2019.100152
   Aekthammarat D, 2019, PHYTOMEDICINE, V54, P9, DOI 10.1016/j.phymed.2018.10.023
   Afifah SZ, 2022, METABOLISM, V128, pS30, DOI 10.1016/j.metabol.2021.155039
   Ajayi T.O, 2020, African Journal of Biomedical Research, V23, P77
   Akaberi M, 2016, PHYTOTHER RES, V30, P540, DOI 10.1002/ptr.5570
   Al-Malki A. L., 2015, BIOMED RES INT-UK, V2015, P13, DOI [10.1155/2015/381040, DOI 10.1155/2015/381040]
   Alam MA, 2014, ADV NUTR, V5, P404, DOI 10.3945/an.113.005603
   Alberti G, 2005, EUR HEART J SUPPL, V7, pD3, DOI 10.1093/eurheartj/sui021
   ALGEBILY MA, 2019, EAJBS C PHYSIOL MOL, V11, P75
   Ali FT., 2015, INT J SCI ENG RES, V6, P1490
   Alves MF, 2005, BRAZ J MED BIOL RES, V38, P861, DOI 10.1590/S0100-879X2005000600007
   Aminifard T, 2021, FOOD SCI NUTR, V9, P5293, DOI 10.1002/fsn3.2475
   Anthanont Pimjai, 2016, Journal of the Medical Association of Thailand, V99, P308
   Anwar F, 2007, PHYTOTHER RES, V21, P17, DOI 10.1002/ptr.2023
   Anwer T, 2021, TROP J PHARM RES, V20, P97, DOI 10.4314/tjpr.v20i1.15
   Asare GA, 2012, J ETHNOPHARMACOL, V139, P265, DOI 10.1016/j.jep.2011.11.009
   Asiedu-Gyekye IJ, 2014, J TOXICOL-US, V2014, DOI 10.1155/2014/786979
   Attakpa ES, 2017, FOLIA BIOL-PRAGUE, V63, P42
   Awodele O, 2012, J ETHNOPHARMACOL, V139, P330, DOI 10.1016/j.jep.2011.10.008
   Azhar S, 2010, FUTUR CARDIOL, V6, P657, DOI [10.2217/fca.10.86, 10.2217/FCA.10.86]
   Babarinde S., 2013, RES ARTICLE INT J BI, V3, P162
   Bais S., 2014, Adv. Biol, V2014, P1, DOI [DOI 10.1155/2014/162914, 10.1155/2014/162914]
   Bamisaye F. A., 2020, FJPAS, V5, P1
   Bao YF, 2020, FOOD CHEM, V311, DOI 10.1016/j.foodchem.2019.125948
   Barter PJ, 2008, ARTERIOSCL THROM VAS, V28, P39, DOI 10.1161/ATVBAHA.107.148817
   Bayliak MM, 2021, EXCLI J, V20, DOI 10.17179/excli2021-4013
   Berger J, 2002, ANNU REV MED, V53, P409, DOI 10.1146/annurev.med.53.082901.104018
   Bhalwar Rajvir, 2020, Med J Armed Forces India, V76, P8, DOI 10.1016/j.mjafi.2019.12.001
   Bhattacharya A, 2018, J PHARM BIOALLIED SC, V10, P181, DOI [10.4103/JPBS.JPBS_126_18, 10.4103/jpbs.JPBS_126_18]
   BJORNTORP P, 1991, DIABETES CARE, V14, P1132, DOI 10.2337/diacare.14.12.1132
   Carvalho BM, 2012, DIABETOLOGIA, V55, P2823, DOI 10.1007/s00125-012-2648-4
   Carvalho E, 2005, AM J PHYSIOL-ENDOC M, V289, pE551, DOI 10.1152/ajpendo.00116.2005
   CHARRON MJ, 1989, P NATL ACAD SCI USA, V86, P2535, DOI 10.1073/pnas.86.8.2535
   Chen KH, 2012, CHINESE J PHYSIOL, V55, P22, DOI 10.4077/CJP.2012.AMM104
   Chinedu Anyanwu A., 2015, J PLANT SCI, V2, P5, DOI 10.11648/j.jps.s.2014020601.12
   Chumark P, 2008, J ETHNOPHARMACOL, V116, P439, DOI 10.1016/j.jep.2007.12.010
   Brito AKD, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020393
   Daba M-H., 2015, Int. J. Adv. Res, V3, P1624
   Dabke K, 2019, J CLIN INVEST, V129, P4050, DOI 10.1172/JCI129194
   de Barros MC, 2022, J ETHNOPHARMACOL, V296, DOI 10.1016/j.jep.2022.115504
   Deacon CF, 2001, DIABETES, V50, P1588, DOI 10.2337/diabetes.50.7.1588
   Demougeot C, 2005, J HYPERTENS, V23, P971, DOI 10.1097/01.hjh.0000166837.78559.93
   Díaz-Prieto LE, 2022, NUTRIENTS, V14, DOI 10.3390/nu14091937
   Avila JAD, 2017, MOLECULES, V22, DOI 10.3390/molecules22060903
   Ebenezer A. M., 2019, J DIABETES ENDOCRINO, V10, P8, DOI [10.5897/jde2018.0126, DOI 10.5897/JDE2018.0126]
   Eggleton J. S., 2023, THIAZOLIDINEDIONES
   El Rabey HA, 2017, INDIAN J BIOCHEM BIO, V54, P306
   El-Bassossy HM, 2013, BRIT J PHARMACOL, V169, P693, DOI 10.1111/bph.12144
   El-Shehawi AM, 2021, J KING SAUD UNIV SCI, V33, DOI 10.1016/j.jksus.2021.101552
   Elabd Elham M Youssef, 2018, Open Access Maced J Med Sci, V6, P1359, DOI 10.3889/oamjms.2018.313
   Ezzat SM, 2020, J ETHNOPHARMACOL, V251, DOI 10.1016/j.jep.2020.112541
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Farzaei MH, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20194957
   Fombang E. N., 2016, Food and Nutrition Sciences, V7, P1021, DOI 10.4236/fns.2016.711099
   Franklin Stanley S., 2006, Metabolic Syndrome and Related Disorders, V4, P287, DOI 10.1089/met.2006.4.287
   FYHRQUIST F, 1995, J HUM HYPERTENS, V9, pS19
   Galavi A, 2021, IRAN J BASIC MED SCI, V24, P3, DOI 10.22038/ijbms.2020.46956.10843
   Gao XY, 2017, APPL MICROBIOL BIOT, V101, P3759, DOI 10.1007/s00253-017-8095-x
   Ghasi S, 2000, J ETHNOPHARMACOL, V69, P21, DOI 10.1016/S0378-8741(99)00106-3
   Gomez-Martinez S, 2022, NUTRIENTS, V14, DOI 10.3390/nu14010057
   Gondo H.K., 2021, J. Adv. Pharm. Educ. Res., V11, P88, DOI [10.51847/FDGccLKxoF, DOI 10.51847/FDGCCLKXOF]
   Graf BL, 2010, CURR OPIN INVEST DR, V11, P1107
   Gupta R, 2012, J DIABETES, V4, P164, DOI 10.1111/j.1753-0407.2011.00173.x
   Han L, 2017, FUTUR CARDIOL, V13, DOI 10.2217/fca-2016-0059
   Hardie DG, 2012, NAT REV MOL CELL BIO, V13, P251, DOI 10.1038/nrm3311
   Harper ME, 2004, ACTA PHYSIOL SCAND, V182, P321, DOI 10.1111/j.1365-201X.2004.01370.x
   Hassani FV, 2016, N-S ARCH PHARMACOL, V389, P931, DOI 10.1007/s00210-016-1256-0
   Hon WM, 2002, ANN NY ACAD SCI, V962, P275, DOI 10.1111/j.1749-6632.2002.tb04074.x
   Hosseini A, 2015, J ENDOCRINOL INVEST, V38, P1147, DOI 10.1007/s40618-015-0313-8
   Hosseini A, 2021, PHYTOTHER RES, V35, P5352, DOI 10.1002/ptr.7144
   Hosseini A, 2018, IRAN J BASIC MED SCI, V21, P1091, DOI 10.22038/IJBMS.2018.31243.7529
   Hou CY, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20030535
   Huang MG, 2023, NUTRIENTS, V15, DOI 10.3390/nu15092203
   Huang THW, 2005, TOXICOL APPL PHARM, V207, P160, DOI 10.1016/j.taap.2004.12.009
   Hussein GME, 2011, PHYTOMEDICINE, V19, P88, DOI 10.1016/j.phymed.2011.06.036
   Hussein S. A., 2019, International Journal of Pharmacy and Pharmaceutical Sciences, V9, P2045
   Hyanek J., 2018, Journal of Nutritional Therapeutics, V7, P51
   Ighodaro OM, 2017, MEDICINA-LITHUANIA, V53, P365, DOI 10.1016/j.medici.2018.02.001
   Irfan HM, 2022, ARCH PHYSIOL BIOCHEM, V128, P1202, DOI 10.1080/13813455.2020.1762661
   Angulo-Bejarano PI, 2019, CURR PHARM DESIGN, V25, P3457, DOI 10.2174/1381612825666191010171819
   Jafari F, 2021, ADV EXP MED BIOL, V1328, P385, DOI 10.1007/978-3-030-73234-9_25
   Jain PG, 2010, REV BRAS FARMACOGN, V20, P969, DOI 10.1590/S0102-695X2010005000038
   Jaja-Chimedza A, 2018, J FUNCT FOODS, V47, P376, DOI 10.1016/j.jff.2018.05.056
   James M, 2020, J DIABETES METAB DIS, V19, P437, DOI 10.1007/s40200-020-00523-2
   Jeffery TD, 2021, J ETHNOPHARMACOL, V270, DOI 10.1016/j.jep.2020.113762
   Johnson R, 2018, PLANTA MED, V84, DOI 10.1055/s-0044-100622
   Joung H, 2017, J MED FOOD, V20, P439, DOI 10.1089/jmf.2016.3860
   Karthivashan G, 2016, PEERJ, V4, DOI 10.7717/peerj.2127
   Karthivashan G, 2013, J FOOD SCI, V78, pC1368, DOI 10.1111/1750-3841.12233
   Kasina S. V. S. K., 2022, Dipeptidyl peptidase IV (DPP IV) inhibitors, P1
   Kessing LV, 2020, HYPERTENSION, V76, P1263, DOI 10.1161/HYPERTENSIONAHA.120.15605
   Khan W, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00577
   Kilany OE, 2020, SAUDI J BIOL SCI, V27, P2733, DOI 10.1016/j.sjbs.2020.06.026
   Kim CG, 2022, PHYTOMEDICINE, V100, DOI 10.1016/j.phymed.2022.154037
   Kim Y, 2018, TOXICOL REP, V5, P418, DOI 10.1016/j.toxrep.2018.02.012
   Klip A, 2019, J BIOL CHEM, V294, P11369, DOI 10.1074/jbc.REV119.008351
   Kou XJ, 2018, NUTRIENTS, V10, DOI 10.3390/nu10030343
   Krishnamoorthy Y, 2022, PREV CHRONIC DIS, V19, DOI 10.5888/pcd19.210231
   Krishnamoorthy Y, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0240971
   Kumolosasi E, 2021, SAINS MALAYS, V50, P769, DOI 10.17576/jsm-2021-5003-18
   Lamou B, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/3517824
   Lee JO, 2012, J BIOL CHEM, V287, P44121, DOI 10.1074/jbc.M112.361386
   Lee MK, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-59203-z
   Lee SH, 2005, BIOCONJUGATE CHEM, V16, P377, DOI 10.1021/bc049735+
   Leguisamo NM, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-100
   Leone A, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101494
   Leone A, 2015, INT J MOL SCI, V16, P12791, DOI 10.3390/ijms160612791
   Leong X. F., 2013, EVID-BASED COMPL ALT, V9, P2013, DOI [10.1155/2013/120732, DOI 10.1155/2013/120732]
   Li LF, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.861588
   Li YF, 2016, BIOCHEM BIOPH RES CO, V480, P534, DOI 10.1016/j.bbrc.2016.10.056
   Lipsy Robert J, 2003, J Manag Care Pharm, V9, P2
   Loh YC, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19010120
   Loloei S, 2019, DIAB MET SYND CLIN R, V13, P1901, DOI 10.1016/j.dsx.2019.04.043
   López M, 2018, J INT MED RES, V46, P3327, DOI 10.1177/0300060518781726
   Lorenzo C, 2003, DIABETES CARE, V26, P3153, DOI 10.2337/diacare.26.11.3153
   Louisa M, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.792794
   Lu YT, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20020322
   Luqman S., 2012, Evidence-Based Complementary and Alternative Medicine, V2012, DOI [DOI 10.1155/2012/519084, 10.1155/2012/519084]
   Mabrouki L, 2020, BIOMED RES INT-UK, V2020, DOI 10.1155/2020/6583603
   Madkhali HA, 2019, TROP J PHARM RES, V18, P2597, DOI 10.4314/tjpr.v18i12.20
   Maiyaki-Musa A., 2016, AFRICAN SCI, V17, P21
   Manguro LOA, 2007, NAT PROD RES, V21, P56, DOI 10.1080/14786410601035811
   Mapfumo Masiline, 2019, J Complement Integr Med, V17, DOI 10.1515/jcim-2019-0045
   Marini HR, 2022, NUTRIENTS, V14, DOI 10.3390/nu14081550
   Marott SCW, 2016, J CLIN ENDOCR METAB, V101, P3212, DOI 10.1210/jc.2015-3777
   Marrufo T, 2013, MOLECULES, V18, P10989, DOI 10.3390/molecules180910989
   Mbikay M, 2012, FRONT PHARMACOL, V3, DOI 10.3389/fphar.2012.00024
   Mehta LK, 2003, J ETHNOPHARMACOL, V86, P191, DOI 10.1016/S0378-8741(03)00075-8
   Meng R, 2011, ANN CLIN LAB SCI, V41, P236
   Mollazadeh H, 2016, IRAN J BASIC MED SCI, V19, P1258, DOI 10.22038/ijbms.2016.7906
   Kadar NNMA, 2021, MOLECULES, V26, DOI 10.3390/molecules26185490
   Muhammad N, 2020, S AFR J BOT, V129, P32, DOI 10.1016/j.sajb.2018.12.003
   Nahar S., 2016, International Journal of Basic Clinical Pharmacology, V5, P1263, DOI [10.18203/2319-2003.ijbcp20162427, DOI 10.18203/2319-2003.IJBCP20162427]
   Ndong M, 2007, J CLIN BIOCHEM NUTR, V40, P229, DOI 10.3164/jcbn.40.229
   Olayaki Luqman A., 2015, Journal of Basic and Clinical Physiology and Pharmacology, V26, P585, DOI 10.1515/jbcpp-2014-0129
   Olson M., 1993, FLORA N AM, V2, P167
   Omobowale T O, 2014, Niger J Physiol Sci, V29, P107
   Omodanisi EI, 2017, TROP J PHARM RES, V16, P1737, DOI 10.4314/tjpr.v16i7.35
   Omodanisi EI, 2017, PHARMACOGN RES, V9, P182, DOI 10.4103/0974-8490.204651
   Oparinde D. P., 2014, INT J BIOMEDICAL ADV, V10, P5, DOI [10.7439/ijbar, DOI 10.7439/IJBAR]
   Othman A.I., 2019, Clinical Phytoscience, V5, P48, DOI DOI 10.1186/S40816-019-0140-0
   Pandu SM, 2018, J FOOD BIOCHEM, V42, DOI 10.1111/jfbc.12553
   Park S, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18116032
   Paula PC, 2017, MOLECULES, V22, DOI 10.3390/molecules22020271
   Popoola J. O., 2020, J HerbMed Pharmacol, V9, P174, DOI [10.34172/jhp.2020.24, DOI 10.34172/JHP.2020.24]
   Randriamboavonjy JI, 2016, AM J HYPERTENS, V29, P873, DOI 10.1093/ajh/hpw001
   Rasheed H, 2022, APPL SCI-BASEL, V12, DOI 10.3390/app12063170
   Razavi BM, 2014, J ENDOCRINOL INVEST, V37, P1031, DOI 10.1007/s40618-014-0150-1
   Regufe Virginia M G, 2020, Porto Biomed J, V5, pe101, DOI 10.1097/j.pbj.0000000000000101
   Remick J, 2008, CARDIOL REV, V16, P129, DOI 10.1097/CRD.0b013e31816b43d3
   Rezkita B. E., 2022, CARDIO METABOLIC SYN, V2, P154, DOI [10.51789/cmsj.2022.2.e11, DOI 10.51789/CMSJ.2022.2.E11]
   Rodrigo R, 2007, HYPERTENS RES, V30, P1159, DOI 10.1291/hypres.30.1159
   Roy SK, 2007, CARBOHYD RES, V342, P2380, DOI 10.1016/j.carres.2007.07.020
   Ruscica M, 2022, CARDIOVASC RES, V118, P3288, DOI 10.1093/cvr/cvac020
   Saba A. B., 2012, J NATURAL SCI ENG TE, V11, P32
   Safhi MM, 2018, KOREAN J PHYSIOL PHA, V22, P493, DOI 10.4196/kjpp.2018.22.5.493
   Sailaja BS, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0248691
   Saini RK, 2016, 3 BIOTECH, V6, DOI 10.1007/s13205-016-0526-3
   Saleem A, 2020, J FOOD BIOCHEM, V44, DOI 10.1111/jfbc.13400
   Salem MI., 2020, Asian-Australasian J Anim Sci, V20, P1, DOI [10.5713/ab.20.0499, DOI 10.5713/AB.20.0499]
   Santana LF, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071608
   Shabbir U, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010206
   Shaikh S, 2021, PHARMACEUTICALS-BASE, V14, DOI 10.3390/ph14060591
   Shakib Z, 2019, PHYTOTHER RES, V33, P2649, DOI 10.1002/ptr.6465
   Shin JA, 2013, J DIABETES INVEST, V4, P334, DOI 10.1111/jdi.12075
   Sholapur H N, 2013, Drug Res (Stuttg), V63, P527, DOI 10.1055/s-0033-1347238
   Singh A., 2011, International Journal of Biological and Medical Research, V2, P824
   Singh Awadhesh Kumar, 2014, Indian J Endocrinol Metab, V18, P753, DOI 10.4103/2230-8210.141319
   Song GJ, 2021, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.561956
   Sreelatha S, 2009, PLANT FOOD HUM NUTR, V64, P303, DOI 10.1007/s11130-009-0141-0
   Srikanthan K, 2016, INT J MED SCI, V13, P25, DOI 10.7150/ijms.13800
   Stohs SJ, 2015, PHYTOTHER RES, V29, P796, DOI 10.1002/ptr.5325
   Sudha P, 2010, Indian J Physiol Pharmacol, V54, P133
   Suman RK, 2016, DIABETES METAB SYNDR, V9, P261, DOI 10.2147/DMSO.S109599
   Sun MC, 2020, J AM COLL NUTR, V39, P54, DOI 10.1080/07315724.2019.1608602
   Tabeshpour J, 2017, IRAN J BASIC MED SCI, V20, P557, DOI 10.22038/IJBMS.2017.8682
   Tabeshpour J, 2017, PHYTOTHER RES, V31, P819, DOI 10.1002/ptr.5805
   Tian HC, 2021, INT J BIOL MACROMOL, V182, P595, DOI 10.1016/j.ijbiomac.2021.03.144
   Tiwari N., 2014, Clin. Pharmacol. Biopharm, V3, DOI [10.4172/2167-065x.1000117, DOI 10.4172/2167-065X.1000117, 10.4172/2167-065X.1000117]
   Tuorkey MJ, 2016, INTERV MED APPL SCI, V8, DOI 10.1556/1646.8.2016.3.7
   Udeogu C., 2019, Asian Journal of Research in Medical and Pharmaceutical Sciences, V7, P1, DOI [10.9734/ajrimps/2019/v7i230119, DOI 10.9734/AJRIMPS/2019/V7I230119]
   Umezawa K, 2018, HUM CELL, V31, P95, DOI 10.1007/s13577-017-0196-4
   Vahabzadeh M, 2018, J SCI FOOD AGR, V98, P4816, DOI 10.1002/jsfa.9115
   Villarruel-López A, 2018, BMC COMPLEM ALTERN M, V18, DOI 10.1186/s12906-018-2180-2
   Vongsak B, 2015, PLANTA MED, V81, P1084, DOI 10.1055/s-0035-1546168
   Wagner N, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9112367
   Wang F, 2021, PHYTOMEDICINE, V86, DOI 10.1016/j.phymed.2019.153066
   Wang F, 2019, J MED FOOD, V22, P907, DOI 10.1089/jmf.2018.4382
   Wang J, 2017, ANN NY ACAD SCI, V1398, P83, DOI 10.1111/nyas.13375
   Wang L, 2021, CARDIOVASC DIABETOL, V20, DOI 10.1186/s12933-020-01188-0
   Wang Y, 2019, CELL REP, V29, P1511, DOI 10.1016/j.celrep.2019.09.070
   Waterman C, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-65722-6
   Waterman C, 2015, MOL NUTR FOOD RES, V59, P1013, DOI 10.1002/mnfr.201400679
   Waterman C, 2014, PHYTOCHEMISTRY, V103, P114, DOI 10.1016/j.phytochem.2014.03.028
   Wisse BE, 2004, J AM SOC NEPHROL, V15, P2792, DOI 10.1097/01.ASN.0000141966.69934.21
   World Health Organization: World Obesity Day, 2022, ACCELERATING ACTION
   Wu HY, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0177654
   Xie J, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01447
   Xiong XJ, 2015, PHYTOMEDICINE, V22, P352, DOI 10.1016/j.phymed.2014.12.013
   Yang R.Y., 2006, Nutritional and functional properties of moringa leaves - from germplasm, to plant, to food, to health
   Yang Y, 2020, MOLECULES, V25, DOI 10.3390/molecules25010189
   Yasoob TB, 2021, J ANIM SCI BIOTECHNO, V12, DOI 10.1186/s40104-021-00586-y
   Yassa HD, 2014, ACTA HISTOCHEM, V116, P844, DOI 10.1016/j.acthis.2014.02.002
   ZEIDAN DW, 2019, EAJBS D HISTOL HIST, V11, P33
   Zhang JM, 2007, INT ANESTHESIOL CLIN, V45, P27, DOI 10.1097/AIA.0b013e318034194e
   Zhao P, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.00999
NR 209
TC 4
Z9 4
U1 1
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD FEB
PY 2024
VL 38
IS 2
BP 755
EP 775
DI 10.1002/ptr.8079
EA NOV 2023
PG 21
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HV6V6
UT WOS:001110151100001
PM 38015048
DA 2025-06-11
ER

PT J
AU Tomou, EM
   Papakyriakopoulou, P
   Skaltsa, H
   Valsami, G
   Kadoglou, NPE
AF Tomou, Ekaterina-Michaela
   Papakyriakopoulou, Paraskevi
   Skaltsa, Helen
   Valsami, Georgia
   Kadoglou, Nikolaos P. E.
TI Bio-Actives from Natural Products with Potential Cardioprotective
   Properties: Isolation, Identification, and Pharmacological Actions of
   Apigenin, Quercetin, and Silibinin
SO MOLECULES
LA English
DT Review
DE apigenin; quercetin; silibinin; silymarin; isolation; identification;
   cardiovascular disease; diabetes mellitus; hypertension; metabolic
   syndrome
ID MYOCARDIAL ISCHEMIA/REPERFUSION INJURY; ANGIOTENSIN-CONVERTING ENZYME;
   TYPE-2 DIABETES-MELLITUS; OXIDATIVE STRESS; ENDOTHELIAL FUNCTION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; SILYBUM-MARIANUM;
   GLUCOSE-UPTAKE; ANTIDIABETIC ACTIVITY
AB Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. As a result, pharmaceutical and non-pharmaceutical interventions modifying risk factors for CVDs are a top priority of scientific research. Non-pharmaceutical therapeutical approaches, including herbal supplements, have gained growing interest from researchers as part of the therapeutic strategies for primary or secondary prevention of CVDs. Several experimental studies have supported the potential effects of apigenin, quercetin, and silibinin as beneficial supplements in cohorts at risk of CVDs. Accordingly, this comprehensive review focused critically on the cardioprotective effects/mechanisms of the abovementioned three bio-active compounds from natural products. For this purpose, we have included in vitro, preclinical, and clinical studies associated with atherosclerosis and a wide variety of cardiovascular risk factors (hypertension, diabetes, dyslipidemia, obesity, cardiac injury, and metabolic syndrome). In addition, we attempted to summarize and categorize the laboratory methods for their isolation and identification from plant extracts. This review unveiled many uncertainties which are still unexplored, such as the extrapolation of experimental results to clinical practice, mainly due to the small clinical studies, heterogeneous doses, divergent constituents, and the absence of pharmacodynamic/pharmacokinetic analyses.
C1 [Tomou, Ekaterina-Michaela; Papakyriakopoulou, Paraskevi; Skaltsa, Helen; Valsami, Georgia] Natl & Kapodistrian Univ Athens, Sch Hlth Sci, Dept Pharm, Athens 15784, Greece.
   [Kadoglou, Nikolaos P. E.] Univ Cyprus, Med Sch, CY-2029 Nicosia, Cyprus.
C3 National & Kapodistrian University of Athens; University of Cyprus
RP Kadoglou, NPE (corresponding author), Univ Cyprus, Med Sch, CY-2029 Nicosia, Cyprus.
EM nikoskad@yahoo.com
RI Kadoglou, Nikolaos/AAA-8639-2021; Valsami, Georgia/AAB-4710-2020
OI Tomou, Ekaterina-Michaela/0000-0002-4313-9657; Papakyriakopoulou,
   Paraskevi/0000-0003-0566-0713; Valsami, Georgia/0000-0002-2395-6844;
   Kadoglou, Nikolaos/0000-0002-7830-3488
CR Abdallah HM, 2011, PHYTOCHEM LETT, V4, P337, DOI 10.1016/j.phytol.2011.07.004
   Abdelhameed RFA, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10111713
   Ahn J, 2008, BIOCHEM BIOPH RES CO, V373, P545, DOI 10.1016/j.bbrc.2008.06.077
   Alam MM, 2014, LIFE SCI, V109, P8, DOI 10.1016/j.lfs.2014.06.005
   Alam W, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10101643
   Albadrani GM, 2021, SAUDI J BIOL SCI, V28, P2772, DOI 10.1016/j.sjbs.2021.02.007
   Alsaidan OA, 2022, S AFR J BOT, V149, P798, DOI 10.1016/j.sajb.2022.04.030
   Anandan S., 2021, IJCRR, V13, P100, DOI [10.31782/IJCRR.2021.13213, DOI 10.31782/IJCRR.2021.13213]
   [Anonymous], 2014, Biomedicine Preventive Nutrition, DOI [DOI 10.1016/J.BIONUT.2014.07.006, 10.1016/J.BIONUT.2014.07.006]
   Ansari P, 2021, PLANTS-BASEL, V10, DOI 10.3390/plants10061190
   Bak MJ, 2016, SEMIN CANCER BIOL, V40-41, P170, DOI 10.1016/j.semcancer.2016.03.001
   Bali EB, 2014, PLANTA MED, V80, P984, DOI 10.1055/s-0034-1382881
   Bernatoniene J, 2014, PLANTA MED, V80, P525, DOI 10.1055/s-0034-1368426
   Bhaskar S, 2016, CELL IMMUNOL, V310, P131, DOI 10.1016/j.cellimm.2016.08.011
   Biedermann D, 2014, NAT PROD REP, V31, P1138, DOI 10.1039/c3np70122k
   Bouderba S, 2014, J DIABETES, V6, P184, DOI 10.1111/1753-0407.12083
   Boydens C, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-016-0366-9
   Bruell V, 2015, BRIT J NUTR, V114, P1263, DOI 10.1017/S0007114515002950
   Chang X, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/5529913
   Chaves DSA, 2011, NAT PROD COMMUN, V6, P961
   Chen X, 2022, CURR RES FOOD SCI, V5, P1985, DOI 10.1016/j.crfs.2022.10.018
   Chen YH, 2020, INT J BIOL SCI, V16, P1972, DOI 10.7150/ijbs.39259
   Cho BO, 2020, J FOOD BIOCHEM, V44, DOI 10.1111/jfbc.13105
   Chu C, 2020, BIOMOL THER, V28, P163
   Cifuentes F, 2018, PHYTOMEDICINE, V50, P99, DOI 10.1016/j.phymed.2018.09.226
   Ciumarnean L, 2020, MOLECULES, V25, DOI 10.3390/molecules25184320
   Clayton ZS, 2021, AM J PHYSIOL-HEART C, V321, pH185, DOI 10.1152/ajpheart.00118.2021
   Cook NC, 1996, J NUTR BIOCHEM, V7, P66, DOI 10.1016/0955-2863(95)00168-9
   Cui YJ, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-016-0393-2
   Dabeek WM, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102288
   de Lima JP, 2021, J ETHNOPHARMACOL, V268, DOI 10.1016/j.jep.2020.113667
   Demirci B, 2014, PHYTOTHER RES, V28, P868, DOI 10.1002/ptr.5067
   DeRango-Adem EF, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.681477
   Dewick PM., 2002, Medicinal natural products: a biosynthetic approach
   Di Costanzo A, 2019, MOLECULES, V24, DOI 10.3390/molecules24112155
   Dianita R, 2019, MOLECULES, V24, DOI 10.3390/molecules24081469
   Paredes MD, 2018, NUTRIENTS, V10, DOI 10.3390/nu10040484
   Dou XJ, 2020, BIOMED PHARMACOTHER, V128, DOI 10.1016/j.biopha.2020.110298
   Duarte J, 2001, BRIT J PHARMACOL, V133, P117, DOI 10.1038/sj.bjp.0704064
   Egert S, 2009, BRIT J NUTR, V102, P1065, DOI 10.1017/S0007114509359127
   Eid HM, 2015, PHARMACOGN MAG, V11, P74, DOI 10.4103/0973-1296.149708
   Eid HM, 2010, MOL NUTR FOOD RES, V54, P991, DOI 10.1002/mnfr.200900218
   El Daibani AA, 2020, NAT PROD RES, V34, P797, DOI 10.1080/14786419.2018.1503264
   Elaine W, 2018, PHYTOMEDICINE, V42, P112, DOI 10.1016/j.phymed.2018.03.028
   Elbarbry F, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21186554
   Esmaeili M.A., 2009, PHARMACOLOGYONLINE, V2, P341
   Esmaeili MA, 2009, PLANTA MED, V75, P1418, DOI 10.1055/s-0029-1185704
   Estrada O, 2005, PHYTOTHER RES, V19, P859, DOI 10.1002/ptr.1703
   Fadul E, 2020, NAT PROD RES, V34, P2456, DOI 10.1080/14786419.2018.1542388
   Fang XK, 2008, LIFE SCI, V82, P615, DOI 10.1016/j.lfs.2007.12.021
   Farkhondeh Tahereh, 2019, Cardiovascular & Hematological Agents in Medicinal Chemistry, V17, P17, DOI 10.2174/1871525717666190114145137
   Fatah NHA, 2020, REC NAT PROD, V14, P410, DOI [10.25135/rnp.18.17.06.108, 10.25135/rnp.189.2005.1647]
   Ferreira LLDM, 2021, PHARMACEUTICS, V13, DOI 10.3390/pharmaceutics13081173
   Gao HL, 2021, CARDIOVASC TOXICOL, V21, P721, DOI 10.1007/s12012-021-09662-1
   Gao XR, 2021, LIPIDS HEALTH DIS, V20, DOI 10.1186/s12944-021-01590-x
   Garelnabi M, 2014, J INT SOC SPORT NUTR, V11, DOI 10.1186/1550-2783-11-22
   Gobalakrishnan S, 2016, J CLIN DIAGN RES, V10, pFF1, DOI 10.7860/JCDR/2016/16393.7566
   Gómez-Zorita S, 2017, J TRANSL MED, V15, DOI 10.1186/s12967-017-1343-0
   Gu M, 2016, FRONT PHARMACOL, V7, DOI 10.3389/fphar.2016.00345
   Guo XP, 2018, MOL NUTR FOOD RES, V62, DOI [10.1002/mnfr.201700772, 10.1002/mnfr.201870045]
   Häckl LPN, 2002, PHARMACOLOGY, V65, P182, DOI 10.1159/000064341
   Hadi A, 2018, COMPLEMENT THER MED, V41, P311, DOI 10.1016/j.ctim.2018.08.010
   Hasan MM, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1929-3
   Hosseini A, 2021, PHYTOTHER RES, V35, P5352, DOI 10.1002/ptr.7144
   Hu J, 2015, CARDIOVASC TOXICOL, V15, P241, DOI 10.1007/s12012-014-9290-y
   Huang HH, 2020, NUTR REV, V78, P615, DOI 10.1093/nutrit/nuz071
   Huwait EA, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.698138
   Hwang SH, 2018, J DIABETES RES, V2018, DOI 10.1155/2018/3276162
   Ibitoye OB, 2018, J FOOD BIOCHEM, V42, DOI 10.1111/jfbc.12627
   Inceoren N, 2022, S AFR J BOT, V149, P682, DOI 10.1016/j.sajb.2022.06.062
   Ingles J, 2019, CIRC-GENOM PRECIS ME, V12, DOI 10.1161/CIRCGEN.119.002460
   International Plant Names Index (IPNI), About us
   Iside C, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.01225
   Islam MN, 2013, ARCH PHARM RES, V36, P542, DOI 10.1007/s12272-013-0069-7
   Jang DS, 2010, ARCH PHARM RES, V33, P875, DOI 10.1007/s12272-010-0610-x
   Jia QL, 2019, INT J MOL MED, V44, P893, DOI 10.3892/ijmm.2019.4263
   Jiang H, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-38711-7
   Jiang YH, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00512
   Jin BH, 2009, EUR J PHARMACOL, V616, P200, DOI 10.1016/j.ejphar.2009.06.020
   Jing ZH, 2016, SCI REP-UK, V6, DOI 10.1038/srep30812
   Jofré I, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/6513416
   Jung CH, 2013, PHYTOTHER RES, V27, P139, DOI 10.1002/ptr.4687
   Kadoglou NPE, 2022, PHARMACEUTICALS-BASE, V15, DOI 10.3390/ph15050538
   Kang SG, 2022, MOLECULES, V27, DOI 10.3390/molecules27217432
   Karkanis A, 2011, IND CROP PROD, V34, P825, DOI 10.1016/j.indcrop.2011.03.027
   Kashyap P, 2022, J FOOD BIOCHEM, V46, DOI 10.1111/jfbc.13950
   Kellici TF, 2015, MOL PHARMACEUT, V12, P954, DOI 10.1021/mp5008053
   Khan F, 2016, NUTRIENTS, V8, DOI 10.3390/nu8090529
   Kim BR, 2020, MOLECULES, V25, DOI 10.3390/molecules25194370
   Kim YS, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-251
   Kondo M, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21197226
   Kren V, 2022, NAT PROD REP, V39, P1264, DOI 10.1039/d2np00013j
   Kumar S, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/382063
   Lee DYW, 2003, J NAT PROD, V66, P1171, DOI 10.1021/np030163b
   Van LV, 2022, BIOMED PHARMACOTHER, V146, DOI 10.1016/j.biopha.2021.112611
   Li S, 2011, FITOTERAPIA, V82, P1081, DOI 10.1016/j.fitote.2011.07.002
   Li SS, 2020, CHIN J INTEGR MED, V26, P114, DOI 10.1007/s11655-019-2942-9
   Lii CK, 2010, J ETHNOPHARMACOL, V128, P213, DOI 10.1016/j.jep.2010.01.018
   Lin XM, 2020, LIFE SCI, V258, DOI 10.1016/j.lfs.2020.118106
   Liu HJ, 2017, MOL CELL BIOCHEM, V428, P9, DOI 10.1007/s11010-016-2913-9
   Lloyd-Jones DM, 2010, CIRCULATION, V121, P586, DOI 10.1161/CIRCULATIONAHA.109.192703
   Loizzo MR, 2007, PHYTOTHER RES, V21, P32, DOI 10.1002/ptr.2008
   Lu XL, 2017, BIOMED PHARMACOTHER, V85, P658, DOI 10.1016/j.biopha.2016.11.077
   Luo YY, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00692
   Ma J, 2022, FRONT CARDIOVASC MED, V9, DOI 10.3389/fcvm.2022.1003852
   Mahajan UB, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18040756
   Malekinejad H, 2012, PHYTOMEDICINE, V19, P583, DOI 10.1016/j.phymed.2012.02.009
   Malik S, 2017, AM J PHYSIOL-RENAL, V313, pF414, DOI 10.1152/ajprenal.00393.2016
   Oliveira MLM, 2020, BIOMED ENVIRON SCI, V33, P690, DOI 10.3967/bes2020.090
   Mariee AD, 2012, PHARM BIOL, V50, P1019, DOI 10.3109/13880209.2012.655424
   Marmouzi I, 2021, J ETHNOPHARMACOL, V265, DOI 10.1016/j.jep.2020.113303
   Materska Matgorzata, 2008, Polish Journal of Food and Nutrition Sciences, V58, P407
   Mazzarotto F, 2020, CIRCULATION, V141, P387, DOI 10.1161/CIRCULATIONAHA.119.037661
   Menezes R, 2017, NUTRIENTS, V9, DOI 10.3390/nu9020117
   Meng SY, 2019, CELL BIOL INT, V43, P65, DOI 10.1002/cbin.11079
   Mohammadi H, 2019, PHYTOTHER RES, V33, P871, DOI 10.1002/ptr.6287
   Mohammadi H, 2020, J DIABETES METAB DIS, V19, P1233, DOI 10.1007/s40200-020-00637-7
   Mokashi P, 2017, BIOMED PHARMACOTHER, V90, P268, DOI 10.1016/j.biopha.2017.03.047
   Moradi-Afrapoli F, 2012, DARU, V20, DOI 10.1186/2008-2231-20-37
   Moreland Nicol, 2002, BMC Complement Altern Med, V2, P10, DOI 10.1186/1472-6882-2-10
   Muñoz-Reyes D, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10060909
   Myoung HJ, 2010, ARCH PHARM RES, V33, P1741, DOI 10.1007/s12272-010-1105-5
   Ono M, 2011, J AGR FOOD CHEM, V59, P13346, DOI 10.1021/jf203490a
   Ostadmohammadi V, 2019, PHYTOTHER RES, V33, P1330, DOI 10.1002/ptr.6334
   Owis AI, 2017, Z NATURFORSCH C, V72, P107, DOI 10.1515/znc-2016-0073
   Palmieri D, 2012, MOL CELL BIOCHEM, V371, P129, DOI 10.1007/s11010-012-1429-1
   Palomino OM, 2017, PLANTA MED, V83, P97, DOI 10.1055/s-0042-113135
   Pang X, 2021, BIOORG MED CHEM LETT, V47, DOI 10.1016/j.bmcl.2021.128211
   Papakyriakopoulou P, 2022, PHARMACEUTICALS-BASE, V15, DOI 10.3390/ph15081019
   Patel RV, 2018, EUR J MED CHEM, V155, P889, DOI 10.1016/j.ejmech.2018.06.053
   Pereira SC, 2018, ATHEROSCLEROSIS, V270, P146, DOI 10.1016/j.atherosclerosis.2018.01.031
   Peterson JJ, 2012, NUTR REV, V70, P491, DOI 10.1111/j.1753-4887.2012.00508.x
   Pferschy-Wenzig EM, 2014, J NAT PROD, V77, P842, DOI 10.1021/np400943b
   Pfeuffer M, 2013, NUTR METAB CARDIOVAS, V23, P403, DOI 10.1016/j.numecd.2011.08.010
   Popiolek-Kalisz J, 2022, CURR PROB CARDIOLOGY, V47, DOI 10.1016/j.cpcardiol.2022.101350
   Popiolek-Kalisz J, 2022, NUTRIENTS, V14, DOI 10.3390/nu14091973
   Prakash P, 2014, EUR J PHARMACOL, V727, P15, DOI 10.1016/j.ejphar.2014.01.038
   Praparatana R, 2022, MOLECULES, V27, DOI 10.3390/molecules27082393
   Puteri MU, 2022, LIFE-BASEL, V12, DOI 10.3390/life12020190
   Qiao Y, 2022, FRONT MICROBIOL, V12, DOI 10.3389/fmicb.2021.805827
   Qin WW, 2016, VASC PHARMACOL, V85, P39, DOI 10.1016/j.vph.2016.07.006
   Radjabian T., 2010, IRAN J PHARM THER, V9, P6367
   Rao L., 2020, INT J PHARM SCI REV, V64, P139, DOI [10.47583/ijpsrr.2020.v64i01.026, DOI 10.47583/IJPSRR.2020.V64I01.026]
   Rao Pragada Rajeswara, 2007, Exp Clin Cardiol, V12, P179
   Rasheed RA, 2022, J KING SAUD UNIV SCI, V34, DOI 10.1016/j.jksus.2022.101946
   Ravari SS., 2021, Obesity Medicine, V26, DOI [DOI 10.1016/J.OBMED.2021.100368, 10.1016/j.obmed.2021.100368]
   Ren B, 2016, EUR J PHARMACOL, V773, P13, DOI 10.1016/j.ejphar.2016.01.002
   Ren K, 2018, CELL PHYSIOL BIOCHEM, V47, P2170, DOI 10.1159/000491528
   Rodrigo R, 2022, MOLECULES, V27, DOI 10.3390/molecules27082564
   Rossoni G, 2005, J AGR FOOD CHEM, V53, P10291, DOI 10.1021/jf052499s
   Sahebkar A, 2017, CRIT REV FOOD SCI, V57, P666, DOI 10.1080/10408398.2014.948609
   Sales DS, 2014, PHYTOTHER RES, V28, P1816, DOI 10.1002/ptr.5206
   Saragusti AC, 2010, EUR J PHARMACOL, V644, P138, DOI 10.1016/j.ejphar.2010.07.001
   Senejoux F, 2012, FITOTERAPIA, V83, P377, DOI 10.1016/j.fitote.2011.11.023
   Senejoux F, 2010, J ETHNOPHARMACOL, V132, P268, DOI 10.1016/j.jep.2010.08.028
   Serban MC, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.115.002713
   Shatylo V, 2021, PHARMANUTRITION, V15, DOI 10.1016/j.phanu.2020.100250
   Shen HH, 2020, J FOOD BIOCHEM, V44, DOI 10.1111/jfbc.13522
   Shen Y, 2012, BIOCHEM PHARMACOL, V84, P1036, DOI 10.1016/j.bcp.2012.07.016
   Song LX, 2001, ARCH BIOCHEM BIOPHYS, V391, P72, DOI 10.1006/abbi.2001.2402
   Song YQ, 2005, J AM COLL NUTR, V24, P376, DOI 10.1080/07315724.2005.10719488
   Sornsuvit C, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/1507834
   Soto C, 2003, COMP BIOCHEM PHYS C, V136, P205, DOI 10.1016/S1532-0456(03)00214-X
   Srinivasan P, 2018, J PHARM ANAL, V8, P109, DOI 10.1016/j.jpha.2017.10.005
   Suganthy N, 2016, BIOMED PHARMACOTHER, V84, P892, DOI 10.1016/j.biopha.2016.10.011
   Sun T, 2019, ANTIOXID REDOX SIGN, V31, P1177, DOI 10.1089/ars.2019.7734
   Sun YH, 2013, PHARM BIOL, V51, P1158, DOI 10.3109/13880209.2013.782320
   Sung Bokyung, 2016, J Cancer Prev, V21, P216, DOI 10.15430/JCP.2016.21.4.216
   Surai PF, 2015, ANTIOXIDANTS-BASEL, V4, P204, DOI 10.3390/antiox4010204
   Tabrizi R, 2020, CRIT REV FOOD SCI, V60, P1855, DOI 10.1080/10408398.2019.1604491
   Tain YL, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19061744
   Tan C, 2015, AFR J TRADIT COMPLEM, V12, P156, DOI 10.4314/ajtcam.v12i3.20
   Tan X, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-13911-w
   Tang D, 2017, EXPERT OPIN DRUG MET, V13, P323, DOI 10.1080/17425255.2017.1251903
   Testai L, 2013, J PHARM PHARMACOL, V65, P750, DOI 10.1111/jphp.12032
   Thiriet M, 2018, BIOMATH BIOMECH MODE, V8, P1, DOI 10.1007/978-3-319-89315-0_1
   Tvrdy V, 2021, MED RES REV, V41, P2195, DOI 10.1002/med.21791
   Ullah A, 2020, MOLECULES, V25, DOI 10.3390/molecules25225243
   Volti GL, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-62
   Voroneanu L, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/5147468
   Wadhwa K, 2022, MOLECULES, V27, DOI 10.3390/molecules27165327
   Wang LM, 2016, MOLECULES, V21, DOI 10.3390/molecules21010055
   Wang Q, 2015, INT IMMUNOPHARMACOL, V27, P24, DOI 10.1016/j.intimp.2015.04.018
   Wang Y, 2013, BRAZ J MED BIOL RES, V46, P861, DOI 10.1590/1414-431X20133036
   Wang YK, 2005, VASC PHARMACOL, V43, P198, DOI 10.1016/j.vph.2005.06.002
   Wang ZL, 2020, J BIOSCIENCES, V45, DOI 10.1007/s12038-020-00047-0
   Wei X, 2017, CLIN SCI, V131, P567, DOI [10.1042/CS20160780, 10.1042/cs20160780]
   Wu LL, 2021, J PHARMACOL EXP THER, V377, P146, DOI 10.1124/jpet.120.000162
   Xie J, 2020, BIOMED PHARMACOTHER, V127, DOI 10.1016/j.biopha.2020.110147
   Xu D, 2019, MOLECULES, V24, DOI 10.3390/molecules24061123
   Xu Q, 2021, CHEM BIODIVERS, V18, DOI 10.1002/cbdv.202100049
   Xu YJ, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.875826
   Yang J, 2018, BIOMED PHARMACOTHER, V102, P344, DOI 10.1016/j.biopha.2018.01.128
   Yang X, 2015, MOL MED REP, V12, P6873, DOI 10.3892/mmr.2015.4293
   Yao ZX, 2021, CLIN NUTR, V40, P3748, DOI 10.1016/j.clnu.2021.04.047
   Zekry SH, 2015, MED CHEM RES, V24, P1964, DOI 10.1007/s00044-014-1269-5
   Zhang M, 2021, BIOORG MED CHEM LETT, V35, DOI 10.1016/j.bmcl.2021.127775
   Zhang SS, 2022, FOOD FUNCT, V13, P3931, DOI [10.1039/d1fo04170c, 10.1039/D1FO04170C]
   Zhang TT, 2019, RESP RES, V20, DOI 10.1186/s12931-019-1041-y
   Zhang YL, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/8492780
   Zhao LL, 2023, J NUTR BIOCHEM, V112, DOI 10.1016/j.jnutbio.2022.109208
   Zhou YT, 2022, BIOMED PHARMACOTHER, V153, DOI 10.1016/j.biopha.2022.113447
NR 202
TC 19
Z9 19
U1 1
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD MAR
PY 2023
VL 28
IS 5
AR 2387
DI 10.3390/molecules28052387
PG 32
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 9U3CI
UT WOS:000947593100001
PM 36903630
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Holmannova, D
   Borsky, P
   Borska, L
   Andrys, C
   Hamakova, K
   Rehacek, V
   Svadlakova, T
   Malkova, A
   Beranek, M
   Palicka, V
   Krejsek, J
   Fiala, Z
AF Holmannova, Drahomira
   Borsky, Pavel
   Borska, Lenka
   Andrys, Ctirad
   Hamakova, Kvetoslava
   Rehacek, Vit
   Svadlakova, Tereza
   Malkova, Andrea
   Beranek, Martin
   Palicka, Vladimir
   Krejsek, Jan
   Fiala, Zdenek
TI Metabolic Syndrome, Clusterin and Elafin in Patients with Psoriasis
   Vulgaris
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE psoriasis; metabolic syndrome; clusterin; elafin
ID ELASTASE-SPECIFIC INHIBITOR; NEUTROPHIL ELASTASE; STRESS;
   RETROTRANSLOCATION; INFLAMMATION; EXPRESSION; SECRETION; LEVEL; ALPHA;
   CELLS
AB Background: Psoriasis is a pathological condition characterized by immune system dysfunction and inflammation. Patients with psoriasis are more likely to develop a wide range of disorders associated with inflammation. Serum levels of various substances and their combinations have been associated with the presence of the disease (psoriasis) and have shown the potential to reflect its activity. The aim of the present study is to contribute to the elucidation of pathophysiological links between psoriasis, its pro-inflammatory comorbidity metabolic syndrome (MetS), and the expression of clusterin and elafin, which are reflected in the pathophysiological "portfolio" of both diseases. Material and methods: Clinical examinations (PASI score), ELISA (clusterin, elafin), and biochemical analyses (parameters of MetS) were performed. Results: We found that patients with psoriasis were more often afflicted by MetS, compared to the healthy controls. Clusterin and elafin levels were higher in the patients than in the controls but did not correlate to the severity of psoriasis. Conclusion: Our data suggest that patients with psoriasis are more susceptible to developing other systemic inflammatory diseases, such as MetS. The levels of clusterin and elafin, which are tightly linked to inflammation, were significantly increased in the patients, compared to the controls, but the presence of MetS in patients did not further increase these levels.
C1 [Holmannova, Drahomira; Borsky, Pavel; Svadlakova, Tereza; Malkova, Andrea; Beranek, Martin; Fiala, Zdenek] Charles Univ Prague, Fac Med Hradec Kralove, Inst Hyg & Prevent Med, Hradec Kralove 50038, Czech Republic.
   [Borsky, Pavel; Borska, Lenka] Charles Univ Prague, Fac Med Hradec Kralove, Inst Pathol Physiol, Hradec Kralove 50003, Czech Republic.
   [Andrys, Ctirad; Svadlakova, Tereza; Krejsek, Jan] Charles Univ Prague, Univ Hosp, Inst Clin Immunol & Allergol, Hradec Kralove 50005, Czech Republic.
   [Andrys, Ctirad; Svadlakova, Tereza; Beranek, Martin; Palicka, Vladimir; Krejsek, Jan] Charles Univ Prague, Fac Med Hradec Kralove, Hradec Kralove 50005, Czech Republic.
   [Hamakova, Kvetoslava] Univ Hosp Hradec Kralove, Clin Dermatol & Venereol, Hradec Kralove 50005, Czech Republic.
   [Rehacek, Vit] Univ Hosp, Transfus Ctr, Hradec Kralove 50005, Czech Republic.
   [Beranek, Martin; Palicka, Vladimir] Charles Univ Prague, Univ Hosp Hradec Kralove, Inst Clin Biochem & Diagnost, Hradec Kralove 50005, Czech Republic.
C3 University Hospital Hradec Kralove; Charles University Prague;
   University Hospital Hradec Kralove; Charles University Prague;
   University Hospital Hradec Kralove; Charles University Prague;
   University Hospital Hradec Kralove; Charles University Prague;
   University Hospital Hradec Kralove; University Hospital Hradec Kralove;
   University Hospital Hradec Kralove; Charles University Prague
RP Borsky, P (corresponding author), Charles Univ Prague, Fac Med Hradec Kralove, Inst Hyg & Prevent Med, Hradec Kralove 50038, Czech Republic.; Borsky, P (corresponding author), Charles Univ Prague, Fac Med Hradec Kralove, Inst Pathol Physiol, Hradec Kralove 50003, Czech Republic.
EM holmd9ar@lfhk.cuni.cz; borskyp@lfhk.cuni.cz; borka@lfhk.cuni.cz;
   andrys@fnhk.cz; kveta@hamakova.cz; RehacekV@lfhk.cuni.cz;
   svadlakovat@lfhk.cuni.cz; MALKA8AR@lfhk.cuni.cz; Beranek@lfhk.cuni.cz;
   Palicka@lfhk.cuni.cz; KrejsekJ@lfhk.cuni.cz; Fiala@lfhk.cuni.cz
RI Palicka, Vladimir/N-1802-2017; Rehacek, Vit/H-4564-2018; Fiala,
   Zdeněk/E-5962-2017; Krejsek, Jan/AAQ-6561-2021; Holmannova,
   Drahomira/G-6260-2017; Beranek, Martin/A-9644-2017; Malkova,
   Andrea/B-1013-2017; Borsky, Pavel/S-6307-2016; Borska,
   Lenka/S-6304-2016; Svadlakova, Tereza/E-5562-2017
OI Beranek, Martin/0000-0002-7422-722X; Malkova,
   Andrea/0000-0001-9444-8065; Borsky, Pavel/0000-0001-5253-2808;
   Holmannova, Drahomira/0000-0002-9865-9991; Borska,
   Lenka/0000-0002-8580-1485; Svadlakova, Tereza/0000-0002-1581-5531
FU Charles University, Faculty of Medicine in Hradec Kralove, the Czech
   Republic [Q40-09, Q40-10, Q40-11, SVV-260543 2020]
FX This researchwas funded by Charles University, Faculty of Medicine in
   Hradec Kralove, the Czech Republic, by projects Q40-09, Q40-10, Q40-11,
   and SVV-260543 2020.
CR Al-Mutairi N, 2010, J DERMATOL, V37, P146, DOI 10.1111/j.1346-8138.2009.00777.x
   Arnold T, 2011, PEDIATR RES, V69, P237, DOI 10.1203/PDR.0b013e31820930cb
   Ataseven A, 2014, DIS MARKERS, V2014, DOI 10.1155/2014/541709
   Balantinou E, 2009, FREE RADICAL BIO MED, V46, P1267, DOI 10.1016/j.freeradbiomed.2009.01.025
   Bermúdez-Humarán LG, 2015, MICROB CELL FACT, V14, DOI 10.1186/s12934-015-0198-4
   Boehncke WH, 2015, LANCET, V386, P983, DOI 10.1016/S0140-6736(14)61909-7
   Borska L, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18112238
   Buquicchio R, 2017, J BIOL REG HOMEOS AG, V31, P785
   Butler MW, 2006, J BIOL CHEM, V281, P34730, DOI 10.1074/jbc.M604844200
   Coimbra S, 2014, WORLD J DERMATOL, V3, P15, DOI DOI 10.5314/wjd.v3.i2.15
   Cunin P, 2016, CELL DEATH DIS, V7, DOI 10.1038/cddis.2016.113
   Das S., 2016, MED J DY PATIL U, V9, P177
   de Felice C, 2007, BIOL-TARGETS THER, V1, P11
   Devauchelle V, 2006, J IMMUNOL, V177, P6471, DOI 10.4049/jimmunol.177.9.6471
   Diane A, 2016, FRONT NUTR, V3, DOI 10.3389/fnut.2016.00044
   Elgharib I, 2019, INT J DERMATOL, V58, P205, DOI 10.1111/ijd.14217
   Essabbani A, 2010, J BIOL CHEM, V285, P4273, DOI 10.1074/jbc.C109.057133
   Fujita H, 2015, EMBO J, V34, P1042, DOI 10.15252/embj.201489897
   Gangaiah N., 2018, CLIN DERMATOL REV, V2, P64
   García-Rodríguez S, 2013, ACTAS DERMO-SIFILOGR, V104, P497, DOI 10.1016/j.ad.2012.11.019
   Giang J, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.00639
   Gil SY, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms2896
   Guyot N, 2005, BIOL CHEM, V386, P391, DOI 10.1515/BC.2005.047
   Guyot N, 2008, J BIOL CHEM, V283, P32377, DOI 10.1074/jbc.M803707200
   Henriksen PA, 2004, J IMMUNOL, V172, P4535, DOI 10.4049/jimmunol.172.7.4535
   Hong GH, 2016, J IMMUNOL, V196, P2021, DOI 10.4049/jimmunol.1500747
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Itakura E, 2020, J CELL BIOL, V219, DOI 10.1083/jcb.201911126
   JENNE DE, 1991, J BIOL CHEM, V266, P11030
   Jin G, 1997, J BIOL CHEM, V272, P26620, DOI 10.1074/jbc.272.42.26620
   Kim TG, 2014, BMB REP, V47, P60, DOI 10.5483/BMBRep.2014.47.2.014
   Kloucková J, 2016, PHYSIOL RES, V65, P481, DOI 10.33549/physiolres.933121
   Korkmaz B, 2010, PHARMACOL REV, V62, P726, DOI 10.1124/pr.110.002733
   Kratzer A, 2014, CARDIOVASC RES, V103, P350, DOI 10.1093/cvr/cvu139
   Li F, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0119955
   Li N, 2013, ONCOGENE, V32, P1933, DOI 10.1038/onc.2012.212
   Malkic Salihbegovic Eldina, 2015, Med Arch, V69, P85, DOI 10.5455/medarh.2015.69.85-87
   McDonald JF, 1997, BIOCHEMISTRY-US, V36, P7464, DOI 10.1021/bi962895r
   Michel D, 1997, BIOCHEM J, V328, P45, DOI 10.1042/bj3280045
   Motta JP, 2011, GASTROENTEROLOGY, V140, P1272, DOI 10.1053/j.gastro.2010.12.050
   Nizard P, 2007, TRAFFIC, V8, P554, DOI 10.1111/j.1600-0854.2007.00549.x
   Papayannopoulos V, 2010, J CELL BIOL, V191, P677, DOI 10.1083/jcb.201006052
   Perez-Chada LM, 2020, CLIN IMMUNOL, V214, DOI 10.1016/j.clim.2020.108397
   Qian M, 2018, EUR REV MED PHARMACO, V22, P4299, DOI 10.26355/eurrev_201807_15426
   Rabinovitch M, 1999, AM J PHYSIOL-LUNG C, V277, pL5, DOI 10.1152/ajplung.1999.277.1.L5
   Samson SL, 2014, ENDOCRIN METAB CLIN, V43, P1, DOI 10.1016/j.ecl.2013.09.009
   Santarlasci V, 2009, EUR J IMMUNOL, V39, P207, DOI 10.1002/eji.200838748
   Savkovic V, 2007, BIOCHEM BIOPH RES CO, V356, P431, DOI 10.1016/j.bbrc.2007.02.148
   Seo HY, 2013, ENDOCRINOLOGY, V154, P1722, DOI 10.1210/en.2012-2009
   Shim YJ, 2012, BIOCHEM BIOPH RES CO, V422, P200, DOI 10.1016/j.bbrc.2012.04.162
   Shimoura N, 2018, J INVEST DERMATOL, V138, P854, DOI 10.1016/j.jid.2017.10.023
   Shu LL, 2018, DIABETES, V67, DOI 10.2337/db18-1732-P
   Simpson AJ, 1999, FEBS LETT, V452, P309, DOI 10.1016/S0014-5793(99)00670-5
   Sol IS, 2016, ALLERGY ASTHMA PROC, V37, P335, DOI 10.2500/aap.2016.37.3953
   Sugiura K, 2009, J INVEST DERMATOL, V129, P2126, DOI 10.1038/jid.2009.51
   Tanaka N, 2000, BRIT J DERMATOL, V143, P728, DOI 10.1046/j.1365-2133.2000.03766.x
   Trougakos IP, 2009, CLIN CANCER RES, V15, P48, DOI 10.1158/1078-0432.CCR-08-1805
   Tsai YS, 2016, ALLERGY ASTHMA PROC, V37, pE15, DOI 10.2500/aap.2016.37.3932
   Vranová HP, 2016, J NEUROL SCI, V361, P117, DOI 10.1016/j.jns.2015.12.023
   Wang J., 2019, GASTROENTEROLOGY, P156, DOI [10.1016/S0016-5085(19)39280-7, DOI 10.1016/S0016-5085(19)39280-7]
   Wei JC, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-06091-7
   Widenmaier SB, 2017, CELL, V171, P1094, DOI 10.1016/j.cell.2017.10.003
   Williams SE, 2006, CLIN SCI, V110, P21, DOI 10.1042/CS20050115
   Won JC, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0103351
   Zeng JR, 2017, J DERMATOL, V44, P863, DOI 10.1111/1346-8138.13806
   Zlibut A., 2019, GUIDE INSULIN, DOI [10.5772/intechopen.79427, DOI 10.5772/INTECHOPEN.79427]
NR 66
TC 18
Z9 18
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD AUG
PY 2020
VL 21
IS 16
AR 5617
DI 10.3390/ijms21165617
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA NI0PL
UT WOS:000565061100001
PM 32764517
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Agbozo, F
   Bannerman, E
   Klomegah, S
   Zotor, F
AF Agbozo, Faith
   Bannerman, Edith
   Klomegah, Senam
   Zotor, Francis
TI Lifestyle habits and perceived wellbeing of adults presenting with
   metabolic syndrome at a diabetic clinic in Ghana: A case-control study
SO HUMAN NUTRITION & METABOLISM
LA English
DT Article
DE Metabolic syndrome; Obesity; Hypertension; Diabetes; Diet; Lifestyle
   habits; Wellbeing; Quality of life; Ghana
ID QUALITY-OF-LIFE; DIETARY PATTERNS; PREVALENCE
AB Background: Heightened by the epidemiological transition associated with excess energy intake, sedentary lifestyle and urbanisation, metabolic syndrome (MetS), previously uncommon in sub-Sahara Africa, is increasingly becoming a public health concern. Methods: We retrospectively assessed the association of diet and socio-demographic indicators as exposure factors to the development of MetS in typical peri-urban and rural settings in Ghana and examined the effect of MetS on the perceived quality of life of patients. One-on-one age- and sex-matched case-control study involving 152 adults aged 45-65 years were recruited from a diabetic clinic. Controls were recruited from communities where cases resided. Case definition was concurrent adiposity, hypertension, diabetes and dyslipidaemia. Lifestyle was assessed using a lifestyle and habits questionnaire, whereas diet history was assessed using a food frequency questionnaire. Differences were tested using McNemar and paired t-tests. To determine which exposure variables significantly predicted the development of MetS, we conducted a conditional logistic regression and reported the Mantel Haenszel crude and adjusted odds ratio (OR). Results: Markers for MetS among the cases and controls were abdominal obesity (98.7% vs 36.8%), hypertension (90.8% vs 2.6%) and diabetes (72.4% vs 1.3%). Controls (77.6%) consumed more diversified diets compared to the cases (10.5%) (p = 0.001). Lower risk for MetS was linked to secondary education (COR = 0.17) and long duration of residence (COR = 0.30) in a peri-urban setting (COR = 0.22) whereas being unemployed (COR = 9.00) increased the risk. Abdominal obesity (COR = 28.51) was a stronger predictor of MetS compared to BMI & GE;30 kg/m2 (COR = 14.80). Comparatively, the controls had a better self-perception of their physical wellbeing (73.7% vs 2.6%), fitness (88.2% vs 13.2%), nutrition and weight control (14.5% vs 1.3%) and psychological health (19.7% vs 0%). Conclusion: Considering that socio-demographic indicators were key exposures to MetS, we recommend interventions that promote the holistic wellbeing of the individual and should be integrated into existing health, social and community-based support services.
C1 [Agbozo, Faith; Bannerman, Edith; Klomegah, Senam; Zotor, Francis] Univ Hlth & Allied Hlth Sci, Sch Publ Hlth, Dept Family & Community Hlth, Ho, Ghana.
   [Agbozo, Faith] Univ Hlth & Allied Hlth Sci, Sch Publ Hlth, Dept Family & Community Hlth, Private Mail Bag 31, Ho, Ghana.
RP Agbozo, F (corresponding author), Univ Hlth & Allied Hlth Sci, Sch Publ Hlth, Dept Family & Community Hlth, Private Mail Bag 31, Ho, Ghana.
EM faagbozo@uhas.edu.gh
RI Agbozo, Faith/AAR-9466-2021
OI Agbozo, Faith/0000-0001-7707-5658; Bannerman, Edith
   Kabukie/0009-0009-9639-9610
CR Agbozo F, 2018, AFR HEALTH SCI, V18, P743, DOI 10.4314/ahs.v18i3.33
   Agyemang-Yeboah F, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/4562904
   Arthur Fareed Kow Nanse, 2013, BMC Res Notes, V6, P446, DOI 10.1186/1756-0500-6-446
   Behncke S, 2012, HEALTH ECON, V21, P282, DOI 10.1002/hec.1712
   Belhayara MI, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030727
   Ben-Yacov L., 2020, BMJ NUTR PREVENTION, DOI [10.1136/bmjnph-2019-000050bmjnph-2019-000050, DOI 10.1136/BMJNPH-2019-000050BMJNPH-2019-000050]
   Bosu WK, 2015, P NUTR SOC, V74, P466, DOI 10.1017/S0029665114001669
   Deshmukh-Taskar PR, 2009, PUBLIC HEALTH NUTR, V12, P2493, DOI 10.1017/S1368980009991261
   Dinzeo TJ, 2014, PREV SCI, V15, P103, DOI 10.1007/s11121-013-0370-1
   Ervin R., 2009, NATL HLTH STAT REPOR
   Fabiani R, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092056
   Garralda-Del-Villar M, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010065
   Gyakobo M, 2012, BMC ENDOCR DISORD, V12, DOI 10.1186/1472-6823-12-25
   Hintikka J, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-410
   Hossain S, 2015, DIABETES METAB SYND, V9, P120, DOI 10.1016/j.dsx.2014.04.016
   Hui ESY, 2016, DIABETES METAB, V42, P126, DOI 10.1016/j.diabet.2015.11.004
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Kitaoka M, 2016, ENVIRON HEALTH PREV, V21, P193, DOI 10.1007/s12199-016-0514-6
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Mogre V, 2014, J DIABETES METAB DIS, V13, DOI 10.1186/2251-6581-13-80
   Nsiah Kwabena, 2015, Int J Appl Basic Med Res, V5, P133, DOI 10.4103/2229-516X.157170
   Osei-Yeboah James, 2017, Int J Chronic Dis, V2017, P8765804, DOI 10.1155/2017/8765804
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Shin JA, 2013, J DIABETES INVEST, V4, P334, DOI 10.1111/jdi.12075
   Sia D, 2019, ARCH PUBLIC HEALTH, V77, DOI 10.1186/s13690-019-0367-8
   Soriano Gaelle, 2018, Journal of Nutrition in Gerontology and Geriatrics, V37, P310, DOI 10.1080/21551197.2018.1505578
   Tasdemir-Ozdes A, 2016, PSYCHOL AGING, V31, P618, DOI 10.1037/pag0000089
   van der Linden EL, 2019, EUR J PUBLIC HEALTH, V29, P906, DOI 10.1093/eurpub/ckz051
NR 28
TC 0
Z9 0
U1 1
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2666-1497
J9 HUM NUTR METAB
JI Hum. Nutr. Metab.
PD SEP
PY 2022
VL 29
AR 200154
DI 10.1016/j.hnm.2022.200154
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA R0QA5
UT WOS:001061462800002
OA gold
DA 2025-06-11
ER

PT J
AU Leung, KC
   Bakr, B
   Chung, CY
   Parmar, M
   Elhindi, J
   Brakoulias, V
AF Leung, Kelvin CY.
   Bakr, Bianca
   Chung, Cindy
   Parmar, Mayuri
   Elhindi, James
   Brakoulias, Vlasios
TI A streamlined multidisciplinary metabolic clinic in psychiatric recovery
   service: a pilot study
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE metabolic syndrome; mental health consumers; streamlined approach;
   multidisciplinary team; inpatient program
ID ILLNESS; HEALTH
AB Background The metabolic syndrome (MetS) is a collection of risk factors for cardiovascular disease and type-2 diabetes, that includes central obesity, hypertension, hyperglycaemia and dyslipidaemia. An audit indicated inadequate MetS screening in an Australian psychiatric recovery service.Objectives We aimed to improve MetS screening, identification and intervention by offering streamlined lifestyle education, clinical reviews and discharge planning. This pilot program prioritized holistic, culturally-sensitive, patient-centric, and trauma-informed approaches to enhance metabolic health outcomes.Methods A Metabolic Clinic was piloted in two psychiatric rehabilitation cottages (n=35), which involved disciplines of dietetics, exercise physiology, diversional therapy, occupational therapy, peer workforce, social work, clinical psychology, pharmacy, nursing and medical. Another cottage (n=15) was assigned as the comparison and received standard care. A 12-week, 3-times-per-week lifestyle and behavioral program, called MetFit, was devised and offered to those identified at screening for the treatment cottages. Outcome measures were feasibility measures, the five metabolic parameters (waist circumference, blood pressure, fasting serum triglycerides, high-density lipoprotein, and glucose), functional measures, and a meal questionnaire.Results The treatment cottages had qualitative advantages in screening and identifying MetS. Of four enrolled consumers in MetFit, an improvement of triglycerides (p=0.08), squats (p=0.02), and push-ups (p=0.07) was observed. Major challenges of enrolment included an overall lack of acknowledgment of its importance, poor motivation of consumers and resources limitation.Conclusions The one-stop provision of groups, peer support and inpatient pathway with multidisciplinary team-integration was generally accepted by consumers and the MDT and has iteratively demonstrated the urgent need for consumer-centered physical care and a cultural shift to foster collaboration within a psychiatric service.
C1 [Leung, Kelvin CY.; Bakr, Bianca; Chung, Cindy; Parmar, Mayuri] Cumberland Hosp, Recovery Serv, WSLHD, Sydney, NSW, Australia.
   [Leung, Kelvin CY.] Res & Educ Network, WSLHD, Sydney, NSW, Australia.
   [Leung, Kelvin CY.; Elhindi, James; Brakoulias, Vlasios] Univ Sydney, Fac Med & Hlth, Sydney, NSW, Australia.
   [Brakoulias, Vlasios] Western Sydney Univ, Sch Med, Sydney, NSW, Australia.
   [Brakoulias, Vlasios] Western Sydney Univ, Translat Hlth Res Inst, Sydney, NSW, Australia.
C3 University of Sydney; Western Sydney University; Western Sydney
   University
RP Leung, KC (corresponding author), Cumberland Hosp, Recovery Serv, WSLHD, Sydney, NSW, Australia.; Leung, KC (corresponding author), Res & Educ Network, WSLHD, Sydney, NSW, Australia.; Leung, KC (corresponding author), Univ Sydney, Fac Med & Hlth, Sydney, NSW, Australia.
EM kelvin.leung1@health.nsw.gov.au
RI Brakoulias, Vlasios/N-1603-2019
OI Brakoulias, Vlasios/0000-0002-4188-4370
FU Otsuka Psychiatry Research Grant; WSLHD Research and Education Network
   Grant
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This work was supported
   by the Otsuka Psychiatry Research Grant 2021 and the WSLHD Research and
   Education Network Grant 2022.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Ball H, 2022, MENT HEALTH PHYS ACT, V22, DOI 10.1016/j.mhpa.2022.100452
   Borek AJ, 2019, HEALTH PSYCHOL REV, V13, P227, DOI 10.1080/17437199.2019.1625282
   Fiorillo A, 2021, ANN GEN PSYCHIATR, V20, DOI 10.1186/s12991-021-00374-y
   Firth J, 2016, PSYCHOL MED, V46, P2869, DOI 10.1017/S0033291716001732
   Gillard S., 2014, Advances in Psychiatric Treatment, V20, P286, DOI [10.1192/apt.bp.113.011940, DOI 10.1192/APT.BP.113.011940]
   John AP, 2009, MED J AUSTRALIA, V190, P176, DOI 10.5694/j.1326-5377.2009.tb02342.x
   Kuppili PP, 2019, INDIAN J PSYCHOL MED, V41, P466, DOI 10.4103/IJPSYM.IJPSYM_48_19
   Lambert Timothy J R, 2003, Med J Aust, V178, pS67
   Leung K., 2023, Aust New Z J Psychiatry, V57, P3
   Morgan VA, 2012, AUST NZ J PSYCHIAT, V46, P735, DOI 10.1177/0004867412449877
   Mutschler C, 2022, PSYCHOL SERV, V19, P360, DOI 10.1037/ser0000531
   NSW Ministry of Health, 2021, NSW Health
   Parker S, 2023, COMMUNITY MENT HLT J, V59, P703, DOI 10.1007/s10597-022-01054-1
   Shalaby RAH, 2020, JMIR MENT HEALTH, V7, DOI 10.2196/15572
   Vancampfort D, 2012, DISABIL REHABIL, V34, P1, DOI 10.3109/09638288.2011.587090
   Vreeland B, 2007, J CLIN PSYCHIAT, V68, P26
   Waterreus AJ, 2009, MED J AUSTRALIA, V190, P185, DOI 10.5694/j.1326-5377.2009.tb02344.x
   Watkins A, 2020, INT J MENT HEALTH NU, V29, P278, DOI 10.1111/inm.12683
   Wyder M, 2020, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.587656
   Zimmet PZ, 2005, MED J AUSTRALIA, V183, P175, DOI 10.5694/j.1326-5377.2005.tb06987.x
NR 21
TC 0
Z9 0
U1 2
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD FEB 20
PY 2024
VL 15
AR 1344453
DI 10.3389/fpsyt.2024.1344453
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA JV2J3
UT WOS:001175869000001
PM 38445084
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sokrateva, T
   Roussev, B
   Nashar, M
   Salim, A
   Ivanova, D
AF Sokrateva, Todorka
   Roussev, Bogdan
   Nashar, Milka
   Salim, Ayshe
   Ivanova, Diana
TI Mineral Waters with a Potential to Control and Prevent Metabolic
   Syndrome: A Systematic Review
SO BALNEO AND PRM RESEARCH JOURNAL
LA English
DT Review
DE mineral water; water intake; metabolic syndrome; obesity; prevention
ID ANGIOTENSIN-ALDOSTERONE SYSTEM; DRINKING-WATER; OXIDATIVE STRESS;
   BLOOD-PRESSURE; RICH WATER; CALCIUM BIOAVAILABILITY; POSTPRANDIAL
   LIPEMIA; INSULIN-RESISTANCE; CALORIC BEVERAGES; SULFUROUS WATER
AB The morbidity rate of metabolic syndrome (MetS) has increased alarmingly in recent years. The intake of mineral water is among the recommendations for a healthy lifestyle in overweight people. The aim of the study was to investigate the effects of mineral water intake on MetS variables such as lipid status, blood pressure, blood glucose levels, and antioxidant defense. The PRISMA guidelines were followed, focusing on the period from 1990 to 2024. Twenty-four studies met the inclusion criteria. Among these, sixteen were randomized controlled crossover trials, one was crossover, six were interventional, and one was of a cyclic type. The included studies were divided by duration into long-term with mineral water intake for at least one month, postprandial, and treatment including mineral water intake. Mineral waters have been tested according to different protocols regarding water composition, amount consumed, with or without changes in lifestyle and diet in healthy subjects or such with impaired biochemical parameters. Regular mineral water intake may have a positive effects on lipid metabolism, blood pressure, glycemic status, and the antioxidant system. These findings can be used as an additional alternative treatment method in risk groups with MetS, obesity, or hyperglycemia.
C1 [Sokrateva, Todorka; Roussev, Bogdan; Nashar, Milka; Salim, Ayshe; Ivanova, Diana] Med Univ Varna, Fac Pharm, Dept Biochem Mol Med & Nutrigen, Varna, Bulgaria.
C3 Medical University Varna
RP Sokrateva, T (corresponding author), Med Univ Varna, Fac Pharm, Dept Biochem Mol Med & Nutrigen, Varna, Bulgaria.
EM sokrateva@mu-varna.bg
FU European Union-NextGenerationEU through the National Recovery and
   Resilience Plan of the Republic of Bulgaria [BGRRP-2.004-0009C02]
FX This research was funded by the European Union-NextGenerationEU through
   the National Recovery and Resilience Plan of the Republic of Bulgaria,
   project no. BGRRP-2.004-0009C02, Research group 3.1.1., Natura4Health.
CR Adrogué HJ, 2014, SEMIN NEPHROL, V34, P257, DOI 10.1016/j.semnephrol.2014.04.003
   Agostoni C, 2010, EFSA J, V8, DOI 10.2903/j.efsa.2010.1459
   Albertini M. C., 2007, International Journal of Environment and Health, V1, P153, DOI 10.1504/IJENVH.2007.012230
   Almeida C., 2010, Press Therm Climat, V147, P110
   Aloulou A, 2008, CELL MOL LIFE SCI, V65, P851, DOI 10.1007/s00018-008-7546-z
   Aslanabadi N, 2014, ADV PHARM BULL, V4, P303, DOI 10.5681/apb.2014.044
   Atlas SA, 2007, J MANAGE CARE PHARM, V13, pS9, DOI 10.18553/jmcp.2007.13.s8-b.9
   Bacciottini L, 2004, J CLIN GASTROENTEROL, V38, P761, DOI 10.1097/01.mcg.0000139031.46192.7e
   Badimon L, 2014, J INTERN MED, V276, P618, DOI 10.1111/joim.12296
   Bae JH, 2003, INT J CARDIOL, V87, P259, DOI 10.1016/S0167-5273(02)00347-9
   Baker S B, 2002, Crit Care Resusc, V4, P301
   Bankir L, 2001, NEPHRON, V87, P8, DOI 10.1159/000045879
   Bastos P, 2014, MAGNESIUM RES, V27, P131, DOI 10.1684/mrh.2014.0369
   Beltrán-Sánchez H, 2013, J AM COLL CARDIOL, V62, P697, DOI 10.1016/j.jacc.2013.05.064
   Benedetti S, 2007, PROG NUTR, V9, P46
   Benedetti S, 2009, EUR J CLIN NUTR, V63, P106, DOI 10.1038/sj.ejcn.1602892
   Benedetti S, 2010, CLIN BIOCHEM, V43, P973, DOI 10.1016/j.clinbiochem.2010.05.004
   Bentley-Lewis R, 2007, J CLIN ENDOCR METAB, V92, P4472, DOI 10.1210/jc.2007-1088
   Bjornstad P, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1101-6
   Böhmer H, 2000, OSTEOPOROSIS INT, V11, P938, DOI 10.1007/s001980070032
   Burckhardt P, 2015, BONEKEY REP, V4, DOI 10.1038/bonekey.2015.77
   Capurso A, 1999, AGING-CLIN EXP RES, V11, P273, DOI 10.1007/BF03339668
   Carroll HA, 2016, BRIT J NUTR, V116, P1770, DOI 10.1017/S0007114516003688
   Casado A, 2015, CRIT REV FOOD SCI, V55, P1633, DOI 10.1080/10408398.2012.692737
   Chalaya Ye.N., 2017, Voprosy kurortologii, fizioterapii i lechebnoy fizicheskoy kul'tury, V3, DOI [10.17116/kurort201794327-31, DOI 10.17116/KURORT201794327-31]
   Cicero AFG, 2016, PHYTOMEDICINE, V23, P1134, DOI 10.1016/j.phymed.2015.11.009
   Costa-Vieira D, 2019, NUTRIENTS, V11, DOI 10.3390/nu11051141
   Costantino M, 2012, CLIN TER, V163, pE13
   Costantino M, 2009, AMINO ACIDS, V36, P161, DOI 10.1007/s00726-008-0032-y
   Costantino M., 2015, PARIPEX-Indian J Res, V4, P69
   Costantino M, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10111773
   Costantino M, 2020, J TRADIT COMPL MED, V10, P320, DOI 10.1016/j.jtcme.2019.04.004
   De Giglio O, 2015, ANN IG MED PREV COMU, V27, P58, DOI 10.7416/ai.2015.2023
   Dennis EA, 2010, OBESITY, V18, P300, DOI 10.1038/oby.2009.235
   Dragomiretska N, 2023, ANN AGR ENV MED, V30, P266, DOI 10.26444/aaem/168673
   Ekmekcioglu C, 2002, FORSCH KOMP KLAS NAT, V9, P216, DOI 10.1159/000066031
   Embleton JK, 1997, ADV DRUG DELIVER REV, V25, P15, DOI 10.1016/S0169-409X(96)00488-7
   Enhörning S, 2010, CIRCULATION, V121, P2102, DOI 10.1161/CIRCULATIONAHA.109.909663
   Farnetti S, 2004, Minerva Gastroenterol Dietol, V50, P277
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Galan P, 2002, J AM DIET ASSOC, V102, P1658, DOI 10.1016/S0002-8223(02)90353-6
   Gommers LMM, 2016, DIABETES, V65, P3, DOI 10.2337/db15-1028
   Gotto AM, 2004, J AM COLL CARDIOL, V43, P717, DOI 10.1016/j.jacc.2003.08.061
   Greupner T, 2017, J AM COLL NUTR, V36, P386, DOI 10.1080/07315724.2017.1299651
   Gushcha S., 2018, American Journal of Chemistry and Materials Science, V5, P85
   Hu FB, 2013, OBES REV, V14, P606, DOI 10.1111/obr.12040
   Huang A, 2018, CLIN DERMATOL, V36, P363, DOI 10.1016/j.clindermatol.2018.03.010
   Jiang L, 2016, NUTRIENTS, V8, DOI 10.3390/nu8010005
   Johnson EC, 2017, NUTR RES, V43, P25, DOI 10.1016/j.nutres.2017.05.004
   Jovicic N, 2023, HELIYON, V9, DOI 10.1016/j.heliyon.2023.e18725
   Kahn Steven E., 2000, American Journal of Medicine, V108, p2S, DOI 10.1016/S0002-9343(00)00336-3
   Karagulle M.Z., 1996, PHYS MED REHAB KUROR, V6, P53
   Karagülle MZ, 2020, INT J BIOMETEOROL, V64, P1011, DOI 10.1007/s00484-019-01829-4
   Katsuda S, 2008, BIOL PHARM BULL, V31, P38, DOI 10.1248/bpb.31.38
   Korolev Yu N, 2022, Vopr Kurortol Fizioter Lech Fiz Kult, V99, P54, DOI 10.17116/kurort20229905154
   Kovács C, 2012, CLIN RHEUMATOL, V31, P1437, DOI 10.1007/s10067-012-2026-0
   Lalovic D, 2020, MOL CELL BIOCHEM, V472, P135, DOI 10.1007/s11010-020-03792-w
   Lastra G, 2009, ENDOCRINOLOGY, V150, P2561, DOI 10.1210/en.2008-1391
   Lemetais G, 2018, EUR J NUTR, V57, P1883, DOI 10.1007/s00394-017-1471-6
   Liu FQ, 2021, J DIABETES INVEST, V12, P658, DOI 10.1111/jdi.13376
   Major GC, 2009, BRIT J NUTR, V101, P659, DOI 10.1017/S0007114508030808
   Malik VS, 2006, AM J CLIN NUTR, V84, P274
   Manna P, 2015, METAB SYNDR RELAT D, V13, P423, DOI 10.1089/met.2015.0095
   Mansouri K, 2024, BLOOD PRESSURE, V33, DOI 10.1080/08037051.2023.2291411
   Carbajo JM, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/8034084
   Marseglia L, 2015, INT J MOL SCI, V16, P378, DOI 10.3390/ijms16010378
   Matz Hagit, 2003, Dermatol Ther, V16, P132, DOI 10.1046/j.1529-8019.2003.01622.x
   Mozaffarian D, 2011, NEW ENGL J MED, V364, P2392, DOI 10.1056/NEJMoa1014296
   Murakami S, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/824395
   Mutchler SM, 2021, HYPERTENSION, V77, P759, DOI 10.1161/HYPERTENSIONAHA.120.14481
   Narciso L, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.886078
   Nerbrand C, 2003, BMC PUBLIC HEALTH, V3, DOI 10.1186/1471-2458-3-21
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Pappan N., 2024, StatPearls Internet
   Pereira C.D., 2012, Rev Port Cirur, V56
   Pereira C.D., 2012, Steroids-From Physiology to Clinical Medicine, P83
   Pereira CD, 2016, HORM MOL BIOL CLIN I, V26, P135, DOI 10.1515/hmbci-2015-0033
   Pereira CD, 2014, INT J ENDOCRINOL, V2014, DOI 10.1155/2014/384583
   Pereira CD, 2015, HORM MOL BIOL CLIN I, V21, P149, DOI 10.1515/hmbci-2014-0032
   Pérez-Granados AM, 2010, J NUTR BIOCHEM, V21, P948, DOI 10.1016/j.jnutbio.2009.07.010
   Pérez-Martínez P, 2017, NUTR REV, V75, P307, DOI 10.1093/nutrit/nux014
   Petraccia L, 2006, CLIN NUTR, V25, P377, DOI 10.1016/j.clnu.2005.10.002
   Quattrini S, 2016, CLIN CASES MINER BON, V13, P173, DOI 10.11138/ccmbm/2016.13.3.173
   Rasic-Milutinovic Z, 2012, J WATER HEALTH, V10, P161, DOI 10.2166/wh.2012.028
   Rauf A, 2022, ENVIRON SCI POLLUT R, V29, P40281, DOI 10.1007/s11356-022-19733-7
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Rose AJ, 2013, MOL CELL ENDOCRINOL, V380, P65, DOI 10.1016/j.mce.2013.03.007
   Roussel R, 2011, DIABETES CARE, V34, P2551, DOI 10.2337/dc11-0652
   Roussev B, 2019, CR ACAD BULG SCI, V72, P1577, DOI 10.7546/CRABS.2019.11.16
   Rylander R, 2004, BMC PUBLIC HEALTH, V4, DOI 10.1186/1471-2458-4-56
   Rylander R, 2008, J NUTR, V138, p423S, DOI 10.1093/jn/138.2.423S
   Sabatier M, 2011, BRIT J NUTR, V106, P331, DOI 10.1017/S0007114511001139
   Salas-Salvadó J, 2011, NUTR METAB CARDIOVAS, V21, pB32, DOI 10.1016/j.numecd.2011.03.009
   Schoppen S, 2007, NUTR HOSP, V22, P538
   Schoppen S, 2005, BRIT J NUTR, V94, P582, DOI 10.1079/BJN20051515
   Schoppen S, 2004, J NUTR, V134, P1058, DOI 10.1093/jn/134.5.1058
   Schoppen S, 2008, INT J FOOD SCI NUTR, V59, P347, DOI 10.1080/09637480701560308
   Schorr U, 1996, J HYPERTENS, V14, P131
   Sheu MJ, 2013, MAR DRUGS, V11, P2183, DOI 10.3390/md11062183
   Sokrateva T.D., Research on the molecular mechanisms of sulfur-containing mineral waters from the Varna Basin on human metabolism in regards to their usage as a drinking remedy, P174
   Sokrateva T, 2022, J IMAB, V28, P4541, DOI 10.5272/jimab.2022283.4541
   Sokrateva T, 2019, J IMAB, V25, P2828, DOI 10.5272/jimab.2019254.2828
   Sokrateva TD, 2021, ARCH PHYSIOL BIOCHEM, V127, P327, DOI 10.1080/13813455.2019.1638416
   Stookey JD, 2007, OBESITY, V15, P3013, DOI 10.1038/oby.2007.359
   Talukder MRR, 2017, ARCH ENVIRON OCCUP H, V72, P126, DOI 10.1080/19338244.2016.1175413
   Tate DF, 2012, AM J CLIN NUTR, V95, P555, DOI 10.3945/ajcn.111.026278
   Teegarden D, 2008, OBESITY, V16, P1566, DOI 10.1038/oby.2008.232
   Toxqui L, 2016, J PHYSIOL BIOCHEM, V72, P635, DOI 10.1007/s13105-016-0502-8
   Toxqui L, 2016, NUTRIENTS, V8, DOI 10.3390/nu8070400
   Toxqui L, 2012, EUR J NUTR, V51, P607, DOI 10.1007/s00394-011-0244-x
   Underwood PC, 2013, CURR HYPERTENS REP, V15, P59, DOI 10.1007/s11906-012-0323-2
   Vitoria I, 2014, NUTR HOSP, V30, P188, DOI 10.3305/nh.2014.30.1.7491
   Volpe SL, 2013, ADV NUTR, V4, p378S, DOI 10.3945/an.112.003483
   Wada T, 2009, ENDOCRINOLOGY, V150, P1662, DOI 10.1210/en.2008-1018
   Wagner CA, 2014, NEPHRON PHYSIOL, V128, P26, DOI 10.1159/000368266
   Walker KZ, 2010, J HUM NUTR DIET, V23, P344, DOI 10.1111/j.1365-277X.2010.01061.x
   Wasserfurth P, 2019, FOOD NUTR RES, V63, DOI [10.29219/fnr.v63.3515, 10.2921/fnr.v63.3515]
   Yanturina N. KH., 2010, Meditsinskiy vestnik Bashkortostana, V3
   Zabolotnaya I B, 2016, Vopr Kurortol Fizioter Lech Fiz Kult, V93, P42, DOI 10.17116/kurort2016442-48
   Zair Y, 2013, LIPIDS HEALTH DIS, V12, DOI 10.1186/1476-511X-12-105
   Ziomber A, 2008, AM J PHYSIOL-RENAL, V295, pF1752, DOI 10.1152/ajprenal.00531.2007
NR 121
TC 0
Z9 0
U1 0
U2 0
PU ROMANIAN ASSOC BALNEOLOGY
PI BUCHAREST
PA SECTOR 2, ALEEA DOBRINA NO 7, BL D10, SC A, AP 4, BUCHAREST, ROMANIA
SN 2734-844X
EI 2734-8458
J9 BALNEO PRM RES J
JI Balneo PRM Res. J.
PD MAR
PY 2025
VL 16
IS 1
AR 773
DI 10.12680/balneo.2025.773
PG 32
WC Rehabilitation
WE Emerging Sources Citation Index (ESCI)
SC Rehabilitation
GA 3IQ6I
UT WOS:001501257600031
DA 2025-06-11
ER

PT J
AU Rodríguez-Correa, E
   González-Pérez, I
   Clavel-Pérez, PI
   Contreras-Vargas, Y
   Carvajal, K
AF Rodriguez-Correa, Eduardo
   Gonzalez-Perez, Imelda
   Clavel-Perez, Pedro Isauro
   Contreras-Vargas, Yolanda
   Carvajal, Karla
TI Biochemical and nutritional overview of diet-induced metabolic syndrome
   models in rats: what is the best choice?
SO NUTRITION & DIABETES
LA English
DT Review
ID HIGH-FAT-DIET; HIGH-FRUCTOSE DIET; INDUCED INSULIN-RESISTANCE; BROWN
   ADIPOSE-TISSUE; HIGH-CARBOHYDRATE; INDUCED OBESITY; CAFETERIA DIET;
   OXIDATIVE STRESS; HYPERTENSIVE-RATS; SUCROSE DIET
AB Metabolic syndrome (MS) is a condition that includes obesity, insulin resistance, dyslipidemias among other, abnormalities that favors type 2 Diabetes Mellitus (T2DM) and cardiovascular diseases development. Three main diet-induced metabolic syndrome models in rats exist: High carbohydrate diet (HCHD), high fat diet (HFD), and high carbohydrate-high fat diet (HCHHFD). We analyzed data from at least 35 articles per diet, from different research groups, to determine their effect on the development of the MS, aimed to aid researchers in choosing the model that better suits their research question; and also the best parameter that defines obesity, as there is no consensus to determine this condition in rats. For the HCHD we found a mild effect on body weight gain and fasting blood glucose levels (FBG), but significant increases in triglycerides, fasting insulin, insulin resistance and visceral fat accumulation. HFD had the greater increase in the parameters previously mentioned, followed by HCHHFD, which had a modest effect on FBG levels. Therefore, to study early stages of MS a HCHD is recommended, while HFD and HCHHFD better reproduce more severe stages of MS. We recommend the assessment of visceral fat accumulation as a good estimate for obesity in the rat.
C1 [Rodriguez-Correa, Eduardo; Gonzalez-Perez, Imelda; Clavel-Perez, Pedro Isauro; Contreras-Vargas, Yolanda; Carvajal, Karla] Inst Nacl Pediat, Lab Nutr Expt, Mexico City, DF, Mexico.
RP Carvajal, K (corresponding author), Inst Nacl Pediat, Lab Nutr Expt, Mexico City, DF, Mexico.
EM karla_ca@yahoo.com
OI Contreras-Vargas, Yolanda/0000-0002-7514-8590; Clavel-Perez, Pedro
   Isauro/0000-0001-7573-9414; Rodriguez-Correa,
   Eduardo/0000-0001-9069-682X
FU CONACYT [619938, 614768]
FX E.R.C. received a scholarship from CONACYT number 619938. I.G.P.
   received a scholarship from CONACYT number 614768. We would like to
   thank Dr. Fernando Gomez-Chavez for the assistance with the figures
   using the Bio Render software.
CR Abd Elwahab AH, 2017, CELL PHYSIOL BIOCHEM, V43, P644, DOI 10.1159/000480649
   Al-Khalifa A, 2009, NUTRITION, V25, P1177, DOI 10.1016/j.nut.2009.04.004
   Albarado-Ibañez A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076534
   Almeida FN., 2013, SCI SPORTS, V28, pe19
   Balderas-Villalobos J, 2013, AM J PHYSIOL-HEART C, V305, pH1344, DOI 10.1152/ajpheart.00211.2013
   Barbosa MA, 2018, J PHYSIOL BIOCHEM, V74, P441, DOI 10.1007/s13105-018-0637-x
   Baselga-Escudero L, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0069817
   Beltowski J, 2009, LIFE SCI, V85, P557, DOI 10.1016/j.lfs.2009.08.002
   Benoit B, 2013, NUTR RES, V33, P952, DOI 10.1016/j.nutres.2013.07.017
   BLAZQUEZ E, 1970, J ENDOCRINOL, V46, P445, DOI 10.1677/joe.0.0460445
   BrahmaNaidu P, 2014, CHEM-BIOL INTERACT, V221, P42, DOI 10.1016/j.cbi.2014.07.008
   Buettner R, 2006, J MOL ENDOCRINOL, V36, P485, DOI 10.1677/jme.1.01909
   Busserolles J, 2003, J NUTR, V133, P1903, DOI 10.1093/jn/133.6.1903
   Buyukdere Y, 2019, PEERJ, V7, DOI 10.7717/peerj.6656
   Cardoso C, 2018, PROSTAG LEUKOTR ESS, V135, P137, DOI 10.1016/j.plefa.2018.07.010
   Carvajal K, 1999, J HYPERTENS, V17, P1607, DOI 10.1097/00004872-199917110-00015
   Chandrasekera PC, 2014, ALTEX-ALTERN ANIM EX, V31, P157, DOI 10.14573/altex.1309231
   Chaves VE, 2012, LIPIDS, V47, P773, DOI 10.1007/s11745-012-3683-0
   Cheng HS, 2017, J ADV RES, V8, P743, DOI 10.1016/j.jare.2017.10.002
   Chien MY, 2019, J TRADIT COMPL MED, V9, P221, DOI 10.1016/j.jtcme.2018.06.003
   Chiu CY, 2017, J FOOD DRUG ANAL, V25, P919, DOI 10.1016/j.jfda.2016.11.015
   Chun MR, 2010, J KOREAN MED SCI, V25, P1053, DOI 10.3346/jkms.2010.25.7.1053
   Chung APYS, 2014, J FUNCT FOODS, V9, P173, DOI 10.1016/j.jff.2014.03.029
   Ciapaite J, 2011, BBA-MOL CELL BIOL L, V1811, P441, DOI 10.1016/j.bbalip.2011.05.005
   Creus A, 2017, PROSTAG LEUKOTR ESS, V121, P30, DOI 10.1016/j.plefa.2017.06.002
   Czech MP, 2017, NAT MED, V23, P804, DOI 10.1038/nm.4350
   Darimont Christian, 2004, Nutr Metab (Lond), V1, P4, DOI 10.1186/1743-7075-1-4
   Acosta-Cota SD, 2019, CAN J PHYSIOL PHARM, V97, P23, DOI 10.1139/cjpp-2018-0353
   de Macedo IC, 2016, ADV PHARMACOL SCI, V2016, DOI 10.1155/2016/7238679
   de Melo AF, 2018, BIOCHIMIE, V150, P16, DOI 10.1016/j.biochi.2018.04.021
   de Queiroz KB, 2014, LIPIDS, V49, P85, DOI 10.1007/s11745-013-3854-7
   Derkach KV, 2017, B EXP BIOL MED+, V163, P184, DOI 10.1007/s10517-017-3762-6
   Durak A, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0790-0
   Dutta R, 2001, DIABETES, V50, P1186, DOI 10.2337/diabetes.50.5.1186
   Ekeleme-Egedigwe CA, 2017, ACTA SCI POLON-TECHN, V16, P431, DOI [10.17306/J.AFS.0504, 10.17306/j.afs.0504, 10.17306/J.AFS.2017.0504]
   El Hafidi M, 2001, J NUTR BIOCHEM, V12, P396, DOI 10.1016/S0955-2863(01)00154-1
   Pahua-Ramos ME, 2014, PLANT FOOD HUM NUTR, V69, P18, DOI 10.1007/s11130-013-0395-4
   Espinosa-Juárez JV, 2017, J SCI FOOD AGR, V97, P4451, DOI 10.1002/jsfa.8308
   Farrokhfall K, 2014, J FUNCT FOODS, V10, P397, DOI 10.1016/j.jff.2014.07.014
   Fernández-Sada E, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/7682569
   Fujimoto S, 2010, LIFE SCI, V87, P679, DOI 10.1016/j.lfs.2010.10.001
   Gajda A.M., 2007, LABNEWS, P775
   García-Díaz DF, 2007, J PHYSIOL BIOCHEM, V63, P337, DOI 10.1007/BF03165765
   Gibas MK, 2017, DIABETES METAB SYND, V11, pS385, DOI 10.1016/j.dsx.2017.03.022
   Gomaa AA, 2019, J PHARM PHARMACOL, V71, P281, DOI 10.1111/jphp.13032
   Natal DIG, 2016, NUTRITION, V32, P1011, DOI 10.1016/j.nut.2016.02.008
   Gómez-Pérez Y, 2008, CELL PHYSIOL BIOCHEM, V22, P539, DOI 10.1159/000185538
   Guyenet SJ, 2012, J CLIN ENDOCR METAB, V97, P745, DOI 10.1210/jc.2011-2525
   Ha SK, 2011, J COMP PATHOL, V145, P88, DOI 10.1016/j.jcpa.2010.11.011
   Hannou SA, 2018, J CLIN INVEST, V128, P545, DOI 10.1172/JCI96702
   Hao L, 2015, FOOD NUTR RES, V59, DOI 10.3402/fnr.v59.28886
   Haque MR, 2018, DRUG RES, V68, P637, DOI 10.1055/a-0590-1956
   Hazarika A, 2016, NUTRITION, V32, P1081, DOI 10.1016/j.nut.2016.03.005
   Hedner T, 2005, BLOOD PRESSURE, V14, P131, DOI 10.1080/08037051510034310
   Huang DW, 2016, NUTR RES, V36, P150, DOI 10.1016/j.nutres.2015.10.001
   Illesca PG, 2017, BIOMED PHARMACOTHER, V88, P1008, DOI 10.1016/j.biopha.2017.01.153
   Guzmán-Gerónimo RI, 2017, J MED FOOD, V20, P110, DOI [10.1089/jmf.2016.0087, 10.1089/jmf.2016.3851]
   James AM, 2012, TRENDS ENDOCRIN MET, V23, P429, DOI 10.1016/j.tem.2012.06.008
   Kaur A, 2019, OBES MED, V14, P100082
   Kolahdouzi S, 2019, LIFE SCI, V220, P32, DOI 10.1016/j.lfs.2019.01.037
   Koo HY, 2008, BBA-MOL BASIS DIS, V1782, P341, DOI 10.1016/j.bbadis.2008.02.007
   Lalanza JF, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0085049
   Lam PH, 2011, BERKELEY J SCI, V15, P1
   Lee H. J., 2017, Autonomic & Autacoid Pharmacology, V37, P37, DOI 10.1111/aap.12057
   Lewis AR, 2019, HELIYON, V5, DOI 10.1016/j.heliyon.2019.e01412
   Li J, 2011, REGUL PEPTIDES, V171, P53, DOI 10.1016/j.regpep.2011.07.004
   Li JX, 2017, BIOCHEM BIOPH RES CO, V484, P336, DOI 10.1016/j.bbrc.2017.01.119
   LOMBARDO YB, 1983, HORM METAB RES, V15, P69, DOI 10.1055/s-2007-1018633
   Lopes CD, 2019, J FOOD SCI TECH MYS, V56, P40, DOI 10.1007/s13197-018-3436-z
   Sousa RML, 2018, NUTR METAB, V15, DOI 10.1186/s12986-018-0290-y
   Macedo IC, 2012, PEPTIDES, V38, P189, DOI 10.1016/j.peptides.2012.08.007
   Maniam J, 2010, PSYCHONEUROENDOCRINO, V35, P717, DOI 10.1016/j.psyneuen.2009.10.013
   Mansouri A, 2018, GASTROENTEROLOGY, V155, P629, DOI 10.1053/j.gastro.2018.06.083
   Martens EA, 2015, CLIN NUTR, V34, P968, DOI 10.1016/j.clnu.2014.10.007
   Mehanna ET, 2018, BIOMED PHARMACOTHER, V108, P1253, DOI 10.1016/j.biopha.2018.09.126
   MERCER SW, 1987, J NUTR, V117, P2147
   Meryem B., 2016, European Chemical Bulletin, V5, P99
   MICKELSEN O, 1955, J NUTR, V57, P541
   Miesel A, 2010, ANN NUTR METAB, V56, P127, DOI 10.1159/000278748
   Milagro FI, 2006, OBESITY, V14, P1118, DOI 10.1038/oby.2006.128
   Moreno-Fernández S, 2018, FOOD FUNCT, V9, P78, DOI [10.1039/C7FO01280B, 10.1039/c7fo01280b]
   Niu Q, 2013, PLOS ONE, V8, DOI [10.1371/journal.pone.0067203, 10.1371/journal.pone.0082713]
   Oliva L, 2017, PEERJ, V5, DOI 10.7717/peerj.3697
   Oliver P, 2014, INT J OBESITY, V36, P225
   Hernández VO, 2018, NUTR HOSP, V35, P588, DOI 10.20960/nh.1506
   Ong ZY, 2013, APPETITE, V65, P189, DOI 10.1016/j.appet.2013.01.014
   Osakabe N, 2014, LIFE SCI, V114, P51, DOI 10.1016/j.lfs.2014.07.041
   Otero-Losada M, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0118700
   Panchal SK, 2011, J CARDIOVASC PHARM, V57, P51, DOI [10.1097/FJC.0b013e3181feb90a, 10.1097/FJC.0b013e31821b1379]
   Panchal SK, 2011, J BIOMED BIOTECHNOL, DOI 10.1155/2011/351982
   Parafati M, 2015, J NUTR BIOCHEM, V26, P938, DOI 10.1016/j.jnutbio.2015.03.008
   Pasarín M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0032785
   Paschen M, 2019, FASEB J, V33, P204, DOI 10.1096/fj.201800826R
   PECKHAM S C, 1962, Res Dev Tech Rep, P23
   Pérez-Echarri N, 2009, BRIT J NUTR, V101, P1059, DOI 10.1017/S0007114508048307
   Pons Z, 2016, EUR J NUTR, V55, P749, DOI 10.1007/s00394-015-0895-0
   Porto Laura C J, 2011, Ther Adv Cardiovasc Dis, V5, P11, DOI 10.1177/1753944710386282
   Poudyal H, 2013, J NUTR BIOCHEM, V24, P1041, DOI 10.1016/j.jnutbio.2012.07.014
   Ramalho L, 2017, NUTR DIABETES, V7, DOI 10.1038/nutd.2016.47
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   REAVEN GM, 1979, J LIPID RES, V20, P371
   Reynés B, 2014, FOOD RES INT, V64, P839, DOI 10.1016/j.foodres.2014.08.012
   Ricci MR., 2005, Animal Lab News, V4, P1
   Rickman C, 2010, CURR PHARM BIOTECHNO, V11, P881, DOI 10.2174/138920110793261980
   ROTHWELL NJ, 1983, BIOSCIENCE REP, V3, P217, DOI 10.1007/BF01122453
   Ruiz-Ramírez A, 2011, AM J PHYSIOL-ENDOC M, V301, pE1198, DOI 10.1152/ajpendo.00631.2010
   Sabater D, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/959420
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sakr Hussein F., 2018, Journal of Basic and Clinical Physiology and Pharmacology, V29, P61, DOI 10.1515/jbcpp-2017-0069
   Samout N, 2016, BIOMED PHARMACOTHER, V84, P1768, DOI 10.1016/j.biopha.2016.10.105
   Sampey BP, 2011, OBESITY, V19, P1109, DOI 10.1038/oby.2011.18
   Scholze J, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-529
   SCLAFANI A, 1976, PHYSIOL BEHAV, V17, P461, DOI 10.1016/0031-9384(76)90109-8
   Sharabi Y, 2007, AM J HYPERTENS, V20, P206, DOI 10.1016/j.amjhyper.2006.08.002
   Sharma N, 2007, AM J HYPERTENS, V20, P403, DOI 10.1016/j.amjhyper.2006.09.022
   Shawky NM, 2019, ENVIRON TOXICOL PHAR, V66, P43, DOI 10.1016/j.etap.2018.12.008
   Shimada M, 2019, NUTR RES, V64, P49, DOI 10.1016/j.nutres.2019.01.002
   Sishi B, 2011, EXP PHYSIOL, V96, P179, DOI 10.1113/expphysiol.2010.054189
   Sour S, 2015, NUTR METAB CARDIOVAS, V25, P382, DOI 10.1016/j.numecd.2015.01.001
   South T, 2012, PHYSIOL BEHAV, V105, P1052, DOI 10.1016/j.physbeh.2011.11.019
   Spadaro PA, 2015, GENET RES, V97, DOI 10.1017/S0016672315000233
   Sreeja S, 2014, ISRN Inflamm, V2014, P641096, DOI 10.1155/2014/641096
   Storlien LH, 1996, DIABETOLOGIA, V39, P621, DOI 10.1007/BF00418533
   Sudhakara G, 2014, J PHYSIOL BIOCHEM, V70, P311, DOI 10.1007/s13105-013-0304-1
   Sumithran P, 2008, OBES RES CLIN PRACT, V2, P1, DOI 10.1016/j.orcp.2007.11.003
   Supakul L, 2014, EUR J NUTR, V53, P919, DOI 10.1007/s00394-013-0595-6
   Toida S, 1996, OBES RES, V4, P561, DOI 10.1002/j.1550-8528.1996.tb00270.x
   Ulla A, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1799-8
   Velasco M, 2012, ISLETS, V4, P302, DOI 10.4161/isl.21374
   Villegas-Romero M, 2018, NUTRIENTS, V10, DOI 10.3390/nu10060728
   Vinothiya K, 2017, BIOMED PHARMACOTHER, V87, P640, DOI 10.1016/j.biopha.2016.12.134
   Virtuoso A, 2018, APPL ANIM BEHAV SCI, V199, P35, DOI 10.1016/j.applanim.2017.10.012
   Wang XK, 2013, EUR J NUTR, V52, P1181, DOI 10.1007/s00394-012-0428-z
   Wang YP, 2012, J BIOMED RES, V26, P219, DOI 10.7555/JBR.26.20120013
   Warden CH, 2008, CELL METAB, V7, P277, DOI 10.1016/j.cmet.2008.03.014
   Wong SK, 2018, EXP CLIN ENDOCR DIAB, V126, P205, DOI 10.1055/s-0043-119352
   Wong SK, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0123-9
   Woolcott OO, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-29362-1
   Yang C, 2019, FOOD RES INT, V116, P1202, DOI 10.1016/j.foodres.2018.10.003
   YUDKIN J, 1967, AM J CLIN NUTR, V20, P108, DOI 10.1093/ajcn/20.2.108
   Zhang XJ, 2011, ACTA HISTOCHEM, V113, P663, DOI 10.1016/j.acthis.2010.09.007
   Zhao L, 2017, EXP THER MED, V14, P5942, DOI 10.3892/etm.2017.5331
NR 142
TC 92
Z9 94
U1 2
U2 32
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2044-4052
J9 NUTR DIABETES
JI Nutr. Diabetes
PD JUL 2
PY 2020
VL 10
IS 1
AR 24
DI 10.1038/s41387-020-0127-4
PG 15
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA ME9SB
UT WOS:000544993200001
PM 32616730
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jurgonski, A
   Juskiewicz, J
   Zdunczyk, Z
AF Jurgonski, Adam
   Juskiewicz, Jerzy
   Zdunczyk, Zenon
TI Ingestion of Black Chokeberry Fruit Extract Leads to Intestinal and
   Systemic Changes in a Rat Model of Prediabetes and Hyperlipidemia
SO PLANT FOODS FOR HUMAN NUTRITION
LA English
DT Article
DE Anthocyanins; Metabolic syndrome; Disaccharidase; Polyphenols; Rat model
ID ARONIA-MELANOCARPA; FRUCTOSE; DIET; JUICE
AB This report presents a complex analysis of changes proceeding in the gut, blood and internal organs of rats with induced oxidative stress, glucose intolerance and hyperlipidemia after dietary supplementation with an extract from black chokeberry (Aronia melanocarpa) fruit, that is a condensed source of polyphenols (714 mg/g), especially anthocyanin glycosides (56.6%). The disturbances mimicking those observed in metabolic syndrome were induced by a high-fructose diet and simultaneous single injection of streptozotocin (20 mg/kg). Dietary supplementation with the chokeberry fruit extract (0.2%) decreased activity of maltase and sucrase as well as increased activity of lactase in the mucosa of the small intestine. Its ingestion led also to the improvement of antioxidant status, especially, the concentration of a lipid peroxidation indicator (TBARS) in organ tissues (liver, kidney and lung) was normalized; some cholesterol-lowering and distinct hypoglycemic actions were also observed. The mechanism of glucose reduction is likely to be multifactorial, and we suggest the factors related with the decreased activity of mucosal disaccharidases important for further investigation. In Conclusion, chokebeny fruit derivatives may act as a promising supplementary therapeutic option in the prevention and treatment of disorders occurring in metabolic syndrome, as well as their complications.
C1 [Jurgonski, Adam; Juskiewicz, Jerzy; Zdunczyk, Zenon] Polish Acad Sci, Inst Anim Reprod & Food Res, Dept Biol Anal Food, PL-10747 Olsztyn, Poland.
C3 Polish Academy of Sciences; Institute of Animal Reproduction & Food
   Research of the Polish Academy of Sciences
RP Jurgonski, A (corresponding author), Polish Acad Sci, Inst Anim Reprod & Food Res, Dept Biol Anal Food, Tuwima 10, PL-10747 Olsztyn, Poland.
EM adam@pan.olsztyn.pl
RI JURGONSKI, Adam/A-5864-2009; JUSKIEWICZ, Jerzy/H-7193-2017; ZDUNCZYK,
   Zenon/H-7272-2017
OI JURGONSKI, Adam/0000-0003-3524-3259; JUSKIEWICZ,
   Jerzy/0000-0003-0068-5970; ZDUNCZYK, Zenon/0000-0002-0640-7552
CR Adachi T, 2003, ENDOCR J, V50, P271, DOI 10.1507/endocrj.50.271
   Bell DR, 2006, J APPL PHYSIOL, V100, P1164, DOI 10.1152/japplphysiol.00626.2005
   Benvenuti S, 2004, J FOOD SCI, V69, pC164
   Busserolles J, 2003, J NUTR, V133, P1903, DOI 10.1093/jn/133.6.1903
   Chavez M, 1998, J CLIN INVEST, V102, P340, DOI 10.1172/JCI603
   DAHLQVIST A, 1964, ANAL BIOCHEM, V7, P18, DOI 10.1016/0003-2697(64)90115-0
   Day AJ, 2003, BIOCHEM PHARMACOL, V65, P1199, DOI 10.1016/S0006-2952(03)00039-X
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Frejnagel Slawomir, 2007, Polish Journal of Food and Nutrition Sciences, V57, P83
   Garg Madhu Chhaya, 1996, Indian Journal of Experimental Biology, V34, P264
   Girard A, 2005, NUTRITION, V21, P240, DOI 10.1016/j.nut.2004.04.022
   Hofírek B, 2001, ACTA VET BRNO, V70, P27, DOI 10.2754/avb200170010027
   Hovmalm HAP, 2004, HEREDITAS, V141, P301, DOI 10.1111/j.1601-5223.2004.01772.x
   Juskiewicz J, 2004, COMP BIOCHEM PHYS A, V139, P513, DOI 10.1016/j.cbpb.2004.10.015
   Murakami I, 1998, SCAND J GASTROENTERO, V33, P1069
   Naruszewicz M, 2007, ATHEROSCLEROSIS, V194, pE179, DOI 10.1016/j.atherosclerosis.2006.12.032
   Ohgami K, 2005, INVEST OPHTH VIS SCI, V46, P275, DOI 10.1167/iovs.04-0715
   Okada M, 1999, DIABETES OBES METAB, V1, P221, DOI 10.1046/j.1463-1326.1999.00028.x
   Oszmianski J, 2005, EUR FOOD RES TECHNOL, V221, P809, DOI 10.1007/s00217-005-0002-5
   Ryszawa N, 2006, J PHYSIOL PHARMACOL, V57, P611
   Skoog SM, 2004, AM J GASTROENTEROL, V99, P2046, DOI 10.1111/j.1572-0241.2004.40266.x
   Sueiro L, 2006, J FOOD SCI, V71, pC480, DOI 10.1111/j.1750-3841.2006.00152.x
   UCHIYAMA M, 1978, ANAL BIOCHEM, V86, P271, DOI 10.1016/0003-2697(78)90342-1
   Valcheva-Kuzmanova S, 2007, METHOD FIND EXP CLIN, V29, P101, DOI 10.1358/mf.2007.29.2.1075349
   Valcheva-Kuzmanova S, 2007, PLANT FOOD HUM NUTR, V62, P19, DOI 10.1007/s11130-006-0036-2
   Valcheva-Kuzmanova S, 2004, EXP TOXICOL PATHOL, V56, P195, DOI 10.1016/j.etp.2004.04.012
NR 26
TC 95
Z9 113
U1 2
U2 27
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0921-9668
EI 1573-9104
J9 PLANT FOOD HUM NUTR
JI Plant Food Hum. Nutr.
PD DEC
PY 2008
VL 63
IS 4
BP 176
EP 182
DI 10.1007/s11130-008-0087-7
PG 7
WC Plant Sciences; Chemistry, Applied; Food Science & Technology; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Chemistry; Food Science & Technology; Nutrition &
   Dietetics
GA 403FP
UT WOS:000263068800005
PM 18726160
DA 2025-06-11
ER

PT J
AU Elbanna, RHM
   Elabd, SOA
   Saleh, MSM
   Alghitany, SIA
AF Elbanna, Rana Hesham Mohamed
   Elabd, Sherif Osama Abdelsalam
   Saleh, Marwa Shafiek Mustafa
   Alghitany, Salma Ibrahim Abdelmohsen
TI Effect of adding noninvasive auricular Vagal nerve stimulation to
   exercise program on emotional eating and stress responsiveness in
   patient with metabolic syndrome
SO DISABILITY AND REHABILITATION
LA English
DT Article; Early Access
DE Vagal nerve stimulations; eating disorder; patient satisfaction;
   hydrocortisone; Metabolic syndrome
ID PHYSICAL-ACTIVITY; CORTISOL; ASSOCIATION; SYSTEM
AB PurposeTo evaluate the effects of vagus nerve stimulation (VNS) on selected health-related outcomes in MetS.MethodsSeventy men with metabolic syndrome (MetS) aged between 45 and 55, with a body mass index (BMI) ranging from 30 to 35 kg/m2, were randomly divided into study group that received a vagus nerve stimulation (VNS) and circuit weight training (CWT) and control group which underwent a CWT. An Emotional Eating Scale (EES) and a Short Assessment of Patient Satisfaction (SAPS) were used to evaluate emotional eating and patient satisfaction with their therapy, respectively. Salivary cortisol levels were measured between 8 and 9 am, and body weight was detected after 8 h of fasting. The clinical trial ID was NCT05785117.ResultsThere was a significant change in EES and SAPS scale scores in both groups post-intervention; however, the study group showed higher scores than the control group. Furthermore, the change percentage of weight and salivary cortisol in the study group was 8.9% and 44.5%, respectively, which were higher than in the control group (2.9% and 40.6%, respectively).ConclusionVNS and CWT were considered promising, simple, and cost-effective interventions for improving emotional eating, patient satisfaction, salivary cortisol, and body weight in individuals with MetS.
C1 [Elbanna, Rana Hesham Mohamed; Alghitany, Salma Ibrahim Abdelmohsen] Cairo Univ, Fac Phys Therapy, Phys Therapy Internal Med Dept, Giza, Egypt.
   [Elabd, Sherif Osama Abdelsalam] May Univ, Fac Phys Therapy, Phys Therapy Internal Med Dept, Cairo, Egypt.
   [Saleh, Marwa Shafiek Mustafa] Cairo Univ, Fac Phys Therapy, Basic Sci Dept, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Cairo University; Egyptian Knowledge Bank
   (EKB); Cairo University
RP Elbanna, RHM (corresponding author), Cairo Univ, Fac Phys Therapy, Phys Therapy Internal Med Dept, Giza, Egypt.
EM rana.hesham@pt.cu.edu.eg
RI saleh, marwa/KBA-5561-2024
CR Annesi JJ, 2015, APPETITE, V95, P219, DOI 10.1016/j.appet.2015.07.012
   Badran BW, 2018, BRAIN STIMUL, V11, P492, DOI 10.1016/j.brs.2017.12.009
   Bayraktar Z, 2023, ARCH ESP UROL, V76, P504, DOI 10.56434/j.arch.esp.urol.20237607.62
   Beydoun MA, 2014, J NUTR, V144, P1139, DOI 10.3945/jn.114.196717
   Boiko AS, 2020, NEUROPSYCH DIS TREAT, V16, P1051, DOI 10.2147/NDT.S247161
   Braun WA, 2005, EUR J APPL PHYSIOL, V94, P500, DOI 10.1007/s00421-005-1383-7
   Breit S, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00044
   Burnatowska E, 2022, NUTRIENTS, V14, DOI 10.3390/nu14193989
   Caplin A, 2021, PSYCHONEUROENDOCRINO, V131, DOI 10.1016/j.psyneuen.2021.105336
   Chu HY, 2022, TOXINS, V14, DOI 10.3390/toxins14120833
   Clancy JA., 2014, Brain Stimul, P1
   Cooper AJ, 2021, CURR OBES REP, V10, P458, DOI 10.1007/s13679-021-00453-x
   Courties A, 2021, JOINT BONE SPINE, V88, DOI 10.1016/j.jbspin.2021.105149
   Crewther BT, 2011, SPORTS MED, V41, P103, DOI 10.2165/11539170-000000000-00000
   D'Agostini M, 2021, PSYCHOPHYSIOLOGY, V58, DOI 10.1111/psyp.13885
   de Lartigue G, 2016, J PHYSIOL-LONDON, V594, P5791, DOI 10.1113/JP271538
   De Silva ST, 2019, DIABETOL METAB SYNDR, V11, DOI 10.1186/s13098-019-0461-7
   Dohle S, 2014, PSYCHOL HEALTH, V29, P1062, DOI 10.1080/08870446.2014.909042
   Evensen K, 2022, NEUROMODULATION, V25, P443, DOI 10.1111/ner.13366
   Fang JL, 2016, BIOL PSYCHIAT, V79, P266, DOI 10.1016/j.biopsych.2015.03.025
   Gellish RL, 2007, MED SCI SPORT EXER, V39, P822, DOI 10.1097/mss.0b013e31803349c6
   Ghadge AA, 2019, CYTOKINE, V121, DOI 10.1016/j.cyto.2019.154735
   Gupta H, 2020, J PUBLIC HEALTH-HEID, V28, P211, DOI 10.1007/s10389-019-01053-9
   Gurel NZ, 2020, BRAIN STIMUL, V13, P47, DOI 10.1016/j.brs.2019.08.002
   Hawthorne G, 2014, J CLIN EPIDEMIOL, V67, P527, DOI 10.1016/j.jclinepi.2013.12.010
   Herhaus B, 2020, TRANSL PSYCHIAT, V10, DOI 10.1038/s41398-020-0729-6
   Howland Robert H, 2014, Curr Behav Neurosci Rep, V1, P64
   Ju QQ, 2024, APPL PSYCHOL-HLTH WE, V16, P1159, DOI 10.1111/aphw.12522
   Kolandouzi S, 2019, PHYSIOL BEHAV, V205, P15, DOI 10.1016/j.physbeh.2018.11.033
   Kuo WC, 2019, OBES REV, V20, P1651, DOI 10.1111/obr.12915
   Lee HB, 2018, J EXERC REHABIL, V14, P666, DOI 10.12965/jer.1836232.116
   Ma CX, 2022, CARDIOVASC DIABETOL, V21, DOI 10.1186/s12933-022-01516-6
   Marcos-Pardo PJ, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-44329-6
   Mazgelyte E, 2021, J MED BIOCHEM, V40, P173, DOI 10.5937/jomb0-26045
   McKinlay CJ., 2017, J Diagnostic Tech Biomed Anal, V6
   Noubiap JJ, 2022, LANCET CHILD ADOLESC, V6, P158, DOI 10.1016/S2352-4642(21)00374-6
   Puterman E, 2011, PSYCHOSOM MED, V73, P604, DOI 10.1097/PSY.0b013e318229e1e0
   Reisinger C, 2021, INT J OBESITY, V45, P12, DOI 10.1038/s41366-020-00713-1
   Sabers A, 2021, EPILEPSY RES, V177, DOI 10.1016/j.eplepsyres.2021.106776
   Seo YG, 2019, OBES REV, V20, P1642, DOI 10.1111/obr.12911
   Sigrist C., 2022, Neuromodulation, P1
   Silva AF, 2022, BIOLOGY-BASEL, V11, DOI 10.3390/biology11060909
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Song YM, 2020, EAT WEIGHT DISORD-ST, V25, P545, DOI 10.1007/s40519-019-00640-9
   Sothmann M S, 1996, Exerc Sport Sci Rev, V24, P267
   Starkweather AR, 2007, BIOL RES NURS, V8, P186, DOI 10.1177/1099800406295990
   Carpio-Arias TV, 2022, CLIN NUTR ESPEN, V49, P314, DOI 10.1016/j.clnesp.2022.03.030
   van Strien T, 2007, HEALTH PSYCHOL, V26, P105, DOI 10.1037/0278-6133.26.1.105
   Vance CGT, 2022, MEDICINA-LITHUANIA, V58, DOI 10.3390/medicina58101332
   Warren CM, 2019, BRAIN STIMUL, V12, P635, DOI 10.1016/j.brs.2018.12.224
   Wittbrodt MT, 2020, BRAIN STIMUL, V13, P1333, DOI 10.1016/j.brs.2020.07.002
   Wolfe Brenda L, 2002, Eat Disord, V10, P115, DOI 10.1080/10640260290081687
   Won E, 2016, CURR NEUROPHARMACOL, V14, P665, DOI 10.2174/1570159X14666151208113006
   Wunsch K, 2019, PSYCHONEUROENDOCRINO, V106, P216, DOI 10.1016/j.psyneuen.2019.03.015
   Young SW, 2022, BMC HEALTH SERV RES, V22, DOI 10.1186/s12913-022-08089-w
   Zhang HY, 2023, J NUTR, V153, P924, DOI 10.1016/j.tjnut.2023.01.026
NR 56
TC 0
Z9 0
U1 0
U2 0
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-8288
EI 1464-5165
J9 DISABIL REHABIL
JI Disabil. Rehabil.
PD 2025 MAY 16
PY 2025
DI 10.1080/09638288.2025.2506824
EA MAY 2025
PG 8
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Rehabilitation
GA 2RU8X
UT WOS:001489784400001
PM 40382680
DA 2025-06-11
ER

PT J
AU Yu, J
   Shen, JY
   Sun, TT
   Zhang, X
   Wong, N
AF Yu, Jun
   Shen, Jiayun
   Sun, Ting Ting
   Zhang, Xiang
   Wong, Nathalie
TI Obesity, insulin resistance, NASH and hepatocellular carcinoma
SO SEMINARS IN CANCER BIOLOGY
LA English
DT Review
DE Hepatocellular carcinoma; NASH; Metabolic syndrome; Insulin resistance;
   Obesity
ID NONALCOHOLIC FATTY LIVER; GROWTH-FACTOR 21; NATURAL-HISTORY;
   CANCER-RISK; HISTOLOGICAL SEVERITY; DISEASE PROGRESSION;
   DIABETES-MELLITUS; HEPATIC STEATOSIS; CELL-DEATH; TNF-ALPHA
AB Epidemiological and clinical data have clearly demonstrated that non-alcoholic steatohepatitis (NASH) predisposes risk to the development of hepatocellular carcinoma (HCC). NASH is the liver manifestation of metabolic syndrome, which constellates obesity, insulin resistance and dyslipidemia. Although the percentage of patients diagnosed annually with NASH-associated HCC is still relatively low, this number signifies a large population due to the rapidly increasing incidence of obesity and diabetes globally. Fundamental studies on lipid storage, regulation of adipose factors, inflammatory cytokine recruitments and oxidative stress have provided insights into NASH as well as metabolic syndrome. Recent evidence also indicates the significant role of genetic factors in contributing to the pathogenesis of NASH and induced hepatic malignancy. In this review, we attempt to collate current research on NASH biology that lead to our understandings on how metabolic disorders may intersect with cancer development. We also discuss study models that have supported discoveries of molecular and cellular defects, and offered a perspective on therapeutic developments. These studies have collectively increased our knowledge on the complex signaling pathways involved in NASH and cancer, and provided the foundation for improved clinical management of patients with metabolic diseases. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Yu, Jun; Shen, Jiayun; Zhang, Xiang] Chinese Univ Hong Kong, Inst Digest Dis, Li Ka Shing Inst Hlth Sci, Shatin, Hong Kong, Peoples R China.
   [Yu, Jun; Shen, Jiayun; Zhang, Xiang] Chinese Univ Hong Kong, Dept Med & Therapeut, Li Ka Shing Inst Hlth Sci, Shatin, Hong Kong, Peoples R China.
   [Sun, Ting Ting; Wong, Nathalie] Chinese Univ Hong Kong, Dept Anat & Cellular Pathol, Shatin, Hong Kong, Peoples R China.
   [Wong, Nathalie] Chinese Univ Hong Kong, State Key Lab Oncol South China, Shatin, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong; Chinese University of Hong Kong;
   Chinese University of Hong Kong; State Key Lab Oncology South China;
   Chinese University of Hong Kong
RP Yu, J (corresponding author), Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China.
EM junyu@cuhk.edu.hk; natwong@cuhk.edu.hk
RI Tingting, Sun/AAU-7019-2021; ZHANG, Xiang/N-7918-2015; Jun,
   Yu/D-8569-2015
OI Jun, Yu/0000-0001-5008-2153
FU Hong Kong Research Grants Council [T12-403/11]
FX This study was support by a Theme-based Research Scheme from the Hong
   Kong Research Grants Council (Ref. No.: T12-403/11).
CR Adams LA, 2005, J HEPATOL, V42, P132, DOI 10.1016/j.jhep.2004.09.012
   Amarapurkar D, 2007, ANN HEPATOL, V6, P161, DOI 10.1016/S1665-2681(19)31922-2
   Aron-Wisnewsky J, 2012, J HEPATOL, V56, P225, DOI 10.1016/j.jhep.2011.04.022
   Arsov T, 2006, BIOCHEM BIOPH RES CO, V342, P1152, DOI 10.1016/j.bbrc.2006.02.032
   Ascha MS, 2010, HEPATOLOGY, V51, P1972, DOI 10.1002/hep.23527
   Assy N, 2000, DIGEST DIS SCI, V45, P1929, DOI 10.1023/A:1005661516165
   Browning JD, 2004, HEPATOLOGY, V40, P1387, DOI 10.1002/hep.20466
   Brzozowska MM, 2009, J GASTROEN HEPATOL, V24, P243, DOI 10.1111/j.1440-1746.2008.05740.x
   Calle EE, 2003, NEW ENGL J MED, V348, P1625, DOI 10.1056/NEJMoa021423
   Cerda C, 2007, J HEPATOL, V47, P412, DOI 10.1016/j.jhep.2007.04.012
   Chalasani N, 2012, GASTROENTEROLOGY, V142, P1592, DOI 10.1053/j.gastro.2012.04.001
   Chalasani N, 2010, GASTROENTEROLOGY, V139, P1567, DOI 10.1053/j.gastro.2010.07.057
   Chen CL, 2008, GASTROENTEROLOGY, V135, P111, DOI 10.1053/j.gastro.2008.03.073
   Chen CH, 2007, J GASTROEN HEPATOL, V22, P1482, DOI 10.1111/j.1440-1746.2006.04615.x
   Cheung O, 2008, HEPATOLOGY, V48, P1810, DOI 10.1002/hep.22569
   Chew V, 2010, J HEPATOL, V52, P370, DOI 10.1016/j.jhep.2009.07.013
   Clark JM, 2003, AM J GASTROENTEROL, V98, P960, DOI [10.1016/S0002-9270(03)00265-X, 10.1111/j.1572-0241.2003.07486.x]
   Colicchio P, 2005, ANN NUTR METAB, V49, P289, DOI 10.1159/000087295
   Coulon S, 2012, CYTOKINE, V59, P442, DOI 10.1016/j.cyto.2012.05.001
   Das SK, 2011, INDIAN J CLIN BIOCHE, V26, P202, DOI 10.1007/s12291-011-0121-7
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   Diehl AM, 2005, HEPATOL RES, V33, P138, DOI 10.1016/j.hepres.2005.09.022
   Donato F, 2006, ONCOGENE, V25, P3756, DOI 10.1038/sj.onc.1209557
   El-Serag HB, 2006, CLIN GASTROENTEROL H, V4, P369, DOI 10.1016/j.cgh.2005.12.007
   El-Serag HB, 2004, GASTROENTEROLOGY, V126, P460, DOI 10.1053/j.gastro.2003.10.065
   Falck-Ytter Y, 2001, SEMIN LIVER DIS, V21, P17, DOI 10.1055/s-2001-12926
   Fan JG, 2009, J HEPATOL, V50, P204, DOI 10.1016/j.jhep.2008.10.010
   Farrell GC, 2006, HEPATOLOGY, V43, pS99, DOI 10.1002/hep.20973
   Farrell GC, 2013, NAT REV GASTRO HEPAT, V10, P307, DOI 10.1038/nrgastro.2013.34
   Feldstein AE, 2009, HEPATOLOGY, V50, P1072, DOI 10.1002/hep.23050
   Harrison SA, 2006, J CLIN GASTROENTEROL, V40, P68, DOI 10.1097/01.mcg.0000190774.91875.d2
   Hashimoto E, 2012, HEPATOL RES, V42, P1, DOI 10.1111/j.1872-034X.2011.00872.x
   Hill-Baskin AE, 2009, HUM MOL GENET, V18, P2975, DOI 10.1093/hmg/ddp236
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Hu ZW, 2009, ACTA GASTRO-ENT BELG, V72, P215
   Hui JM, 2004, HEPATOLOGY, V40, P46, DOI 10.1002/hep.20280
   Ishii H, 2009, J HEPATOL, V50, P562, DOI 10.1016/j.jhep.2008.10.031
   Jee SH, 2005, JAMA-J AM MED ASSOC, V293, P194, DOI 10.1001/jama.293.2.194
   Joka D, 2012, HEPATOLOGY, V55, P455, DOI 10.1002/hep.24734
   Jou J, 2008, SEMIN LIVER DIS, V28, P370, DOI 10.1055/s-0028-1091981
   Kallivitz ER, 2007, J CLIN GASTROENTEROL, V41, P918, DOI 10.1097/01.mcg.0000225692.62121.55
   Kawaguchi T, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038322
   Kim KH, 2013, NAT MED, V19, P83, DOI 10.1038/nm.3014
   Krawczyk K, 2009, J PHYSIOL PHARMACOL, V60, P71
   Larsson SC, 2008, LANCET, V371, P536, DOI 10.1016/S0140-6736(08)60247-0
   Larter CZ, 2012, J GASTROEN HEPATOL, V27, P341, DOI 10.1111/j.1440-1746.2011.06939.x
   Lee JS, 2005, CARCINOGENESIS, V26, P1013, DOI 10.1093/carcin/bgi030
   Leite NC, 2009, LIVER INT, V29, P113, DOI 10.1111/j.1478-3231.2008.01718.x
   Li HT, 2013, J HEPATOL, V58, P557, DOI 10.1016/j.jhep.2012.10.029
   Liao R, 2013, J EXP CLIN CANC RES, V32, DOI 10.1186/1756-9966-32-3
   Maeda S, 2010, GASTROENT RES PRACT, V2010, DOI 10.1155/2010/367694
   Maiuri MC, 2009, CELL DEATH DIFFER, V16, P87, DOI 10.1038/cdd.2008.131
   Malhi H, 2006, J BIOL CHEM, V281, P12093, DOI 10.1074/jbc.M510660200
   Milner KL, 2009, HEPATOLOGY, V49, P1926, DOI 10.1002/hep.22896
   MOLLER H, 1994, EUR J CANCER, V30A, P344, DOI 10.1016/0959-8049(94)90254-2
   Musso G, 2013, OBES REV, V14, P417, DOI 10.1111/obr.12020
   Nishida T, 2013, LAB INVEST, V93, P230, DOI 10.1038/labinvest.2012.155
   Nordenstedt H, 2010, DIGEST LIVER DIS, V42, pS206, DOI 10.1016/S1590-8658(10)60507-5
   Page JM, 2009, CLIN LIVER DIS, V13, P631, DOI 10.1016/j.cld.2009.07.007
   Paradis V, 2013, GUT, V62, P911, DOI 10.1136/gutjnl-2012-302091
   Park EJ, 2010, CELL, V140, P197, DOI 10.1016/j.cell.2009.12.052
   Polesel J, 2009, ANN ONCOL, V20, P353, DOI 10.1093/annonc/mdn565
   Polyzos SA, 2011, METABOLISM, V60, P313, DOI 10.1016/j.metabol.2010.09.003
   Prashanth M, 2009, J Assoc Physicians India, V57, P205
   Qian Yan, 2005, Hepatobiliary Pancreat Dis Int, V4, P173
   Qu XP, 2003, J CLIN INVEST, V112, P1809, DOI 10.1172/JCI200320039
   Reinehr T, 2012, J CLIN ENDOCR METAB, V97, P2143, DOI 10.1210/jc.2012-1221
   Renehan AG, 2008, LANCET, V371, P569, DOI 10.1016/S0140-6736(08)60269-X
   Romeo S, 2008, NAT GENET, V40, P1461, DOI 10.1038/ng.257
   Rotman Y, 2010, HEPATOLOGY, V52, P894, DOI 10.1002/hep.23759
   Ruiz AG, 2007, OBES SURG, V17, P1374
   Sasaki Y, 2006, J GASTROENTEROL, V41, P1135, DOI 10.1007/s00535-006-1982-z
   Schwimmer JB, 2009, GASTROENTEROLOGY, V136, P1585, DOI 10.1053/j.gastro.2009.01.050
   Serfaty L, 2008, DIABETES METAB, V34, P634, DOI 10.1016/S1262-3636(08)74597-X
   Smedile A, 2005, Eur Rev Med Pharmacol Sci, V9, P291
   Sookoian S, 2011, HEPATOLOGY, V53, P1883, DOI 10.1002/hep.24283
   Sorrentino P, 2009, J HEPATOL, V50, P351, DOI 10.1016/j.jhep.2008.09.011
   Speliotes EK, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1001324
   Speliotes EK, 2010, HEPATOLOGY, V52, P904, DOI 10.1002/hep.23768
   Starley BQ, 2010, HEPATOLOGY, V51, P1820, DOI 10.1002/hep.23594
   Stickel F, 2010, GUT, V59, P1303, DOI 10.1136/gut.2009.199661
   Struben VMD, 2000, AM J MED, V108, P9, DOI 10.1016/S0002-9343(99)00315-0
   Sumida Y, 2003, J HEPATOL, V38, P32, DOI 10.1016/S0168-8278(02)00331-8
   Tamimi TIAR, 2011, J HEPATOL, V54, P1224, DOI 10.1016/j.jhep.2010.08.023
   Teoh NC, 2008, J GASTROEN HEPATOL, V23, P1633, DOI 10.1111/j.1440-1746.2008.05648.x
   Tietge UJF, 2005, HEPATOLOGY, V41, P401, DOI 10.1002/hep.20546
   Toffanin S, 2010, CANCER CELL, V17, P115, DOI 10.1016/j.ccr.2010.01.018
   Tybl E, 2011, J HEPATOL, V54, P994, DOI 10.1016/j.jhep.2010.08.034
   Valenti L, 2010, HEPATOLOGY, V51, P1209, DOI 10.1002/hep.23622
   Vernon G, 2011, ALIMENT PHARM THER, V34, P274, DOI 10.1111/j.1365-2036.2011.04724.x
   Walczak H, 2011, IMMUNOL REV, V244, P9, DOI 10.1111/j.1600-065X.2011.01066.x
   Wang B., 2010, J DIFFER EQUATIONS, V2010, P1
   Watanabe S, 2007, J GASTROEN HEPATOL, V22, pS96, DOI 10.1111/j.1440-1746.2006.04665.x
   Wei YG, 2011, DIGEST DIS SCI, V56, P2227, DOI 10.1007/s10620-011-1617-y
   Wei YR, 2006, AM J PHYSIOL-ENDOC M, V291, pE275, DOI 10.1152/ajpendo.00644.2005
   Williams CD, 2011, GASTROENTEROLOGY, V140, P124, DOI 10.1053/j.gastro.2010.09.038
   Williamson RM, 2011, DIABETES CARE, V34, P1139, DOI 10.2337/dc10-2229
   Wolk A, 2001, CANCER CAUSE CONTROL, V12, P13, DOI 10.1023/A:1008995217664
   Wong VWS, 2009, ALIMENT PHARM THER, V29, P387, DOI 10.1111/j.1365-2036.2008.03896.x
   Wong VWS, 2013, J GASTROEN HEPATOL, V28, P18, DOI 10.1111/jgh.12011
   Wong VWS, 2010, GUT, V59, P969, DOI 10.1136/gut.2009.205088
   Yan SQ, 2001, CANCER RES, V61, P5016
   Yilmaz Y, 2007, WORLD J GASTROENTERO, V13, P837, DOI 10.3748/wjg.v13.i6.837
   Yilmaz Y, 2012, HEPATOLOGY, V55, P654, DOI 10.1002/hep.25520
   Yilmaz Y, 2010, EUR J CLIN INVEST, V40, P887, DOI 10.1111/j.1365-2362.2010.02338.x
   Younossi ZM, 2008, OBES SURG, V18, P1430, DOI 10.1007/s11695-008-9506-y
   Zeng CX, 2010, HEPATOLOGY, V52, P1702, DOI 10.1002/hep.23875
   Zhou YJ, 2010, J GASTROEN HEPATOL, V25, P772, DOI 10.1111/j.1440-1746.2009.06144.x
NR 108
TC 125
Z9 143
U1 1
U2 43
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1044-579X
EI 1096-3650
J9 SEMIN CANCER BIOL
JI Semin. Cancer Biol.
PD DEC
PY 2013
VL 23
IS 6
BP 483
EP 491
DI 10.1016/j.semcancer.2013.07.003
PN B
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 280EP
UT WOS:000329011800003
PM 23876851
DA 2025-06-11
ER

PT J
AU Chang, CC
   Fang, WH
   Chang, HA
   Chen, TY
   Huang, SY
AF Chang, Chuan-Chia
   Fang, Wen-Hui
   Chang, Hsin-An
   Chen, Tien-Yu
   Huang, San-Yuan
TI Sex-Specific Association Between Nerve Growth Factor Polymorphism and
   Cardiac Vagal Modulation
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE nerve growth factor; polymorphism; autonomic nervous system; heart rate
   variability
ID HEART-RATE-VARIABILITY; POWER SPECTRUM ANALYSIS; NEUROTROPHIC FACTORS;
   SYMPATHOVAGAL BALANCE; METABOLIC SYNDROME; ANXIETY; NGF; EXPRESSION;
   ESTROGEN; BEHAVIOR
AB Objective Substantial research has shown that anxiety disorders are associated with decreased cardiac vagal tone, which is a known risk factor for cardiac vulnerability. A functional nerve growth factor (NGF) polymorphism (rs6330, c.104C > T, p.Ala35Val) has been associated with anxiety such that in males but not females, T-allele carriers exhibit higher levels of trait anxiety. Here we investigate whether the nonsynonymous NGF variant has an effect on cardiac autonomic control.
   Methods From 705 adults initially screened for medical and psychiatric illnesses, a final cohort of 580 healthy Han Chinese (352 men, 228 women; mean [standard deviation] age = 34.46 [8.45] years) was included in the NGF genotyping (C/C: 428% [73.8%] and T-allele carriers: 152% [26.2%]). Short-term heart rate variability was used to assess cardiac autonomic function.
   Results There were significant genotype-by-sex interaction effects (p < .05) on high-frequency power (HF) and root mean square of successive heartbeat interval differences (RMSSD), both indices of cardiac vagal control. Even after adjusting for possible confounders, men with any T allele showed lower HF and RMSSD compared with men with the C/C genotype. Women, however, showed an opposite but nonsignificant pattern.
   Conclusions The studied NGF polymorphism modulates autonomic outflow to the heart in a sex-dependent manner. The findings support the view that male T-allele carriers are at increased susceptibility for anxiety by association with low vagal activity and suggest a potential sex-specific genetic link between the highly comorbid anxiety disorders and cardiovascular diseases.
C1 [Chang, Chuan-Chia; Chang, Hsin-An; Chen, Tien-Yu; Huang, San-Yuan] Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Psychiat, Taipei 114, Taiwan.
   [Fang, Wen-Hui] Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Family & Community Med, Taipei 114, Taiwan.
   [Chang, Chuan-Chia; Huang, San-Yuan] Natl Def Med Ctr, Grad Inst Med Sci, Taipei, Taiwan.
C3 Tri-Service General Hospital; National Defense Medical Center;
   Tri-Service General Hospital; National Defense Medical Center; National
   Defense Medical Center
RP Huang, SY (corresponding author), Tri Serv Gen Hosp, Dept Psychiat, Grad Inst Med Sci, Natl Def Med Ctr, 325,Sec 2,Cheng Kung Rd, Taipei 114, Taiwan.
EM hsy@ndmctsgh.edu.tw
RI Cheng, Yeung/AFN-3087-2022; Chen, Han-Shen/E-5881-2018
OI Chang, Hsin-An/0000-0001-5572-7109; Chen, Tien-Yu/0000-0001-8462-1311
FU Tri-Service General Hospital [TSGH-C101-120, TSGH-C102-122,
   TSGH-C103-130]
FX This research was supported by grants from Tri-Service General Hospital
   (TSGH-C101-120, TSGH-C102-122, and TSGH-C103-130). The authors report no
   conflicts of interest.
CR AKSELROD S, 1981, SCIENCE, V213, P220, DOI 10.1126/science.6166045
   Alleva E, 2001, PHYSIOL BEHAV, V73, P313, DOI 10.1016/S0031-9384(01)00498-X
   [Anonymous], 1998, J CLIN PSYCHIAT
   [Anonymous], 1994, AM PSYCHIATR ASSOC
   APPEL ML, 1989, J AM COLL CARDIOL, V14, P1139, DOI 10.1016/0735-1097(89)90408-7
   Bjorling DE, 2002, NEUROSCIENCE, V110, P155, DOI 10.1016/S0306-4522(01)00568-1
   Blechert J, 2007, PSYCHOSOM MED, V69, P935, DOI 10.1097/PSY.0b013e31815a8f6b
   Camm AJ, 1996, CIRCULATION, V93, P1043
   Chaldakov GN, 2004, PROG BRAIN RES, V146, P279, DOI 10.1016/S0079-6123(03)46018-4
   Chang YW, 2012, RES DEV DISABIL, V33, P1701, DOI 10.1016/j.ridd.2012.04.005
   Cohen H, 1999, PSYCHOTHER PSYCHOSOM, V68, P59, DOI 10.1159/000012314
   Cohen H, 2006, AUTON NEUROSCI-BASIC, V128, P1, DOI 10.1016/j.autneu.2005.06.007
   Crisan LG, 2009, SOC COGN AFFECT NEUR, V4, P399, DOI 10.1093/scan/nsp019
   DU XJ, 1995, CARDIOVASC RES, V30, P161, DOI 10.1016/0008-6363(95)00030-5
   El-Mas MM, 2001, J CARDIOVASC PHARM, V38, P754, DOI 10.1097/00005344-200111000-00012
   Ellis AJ, 2011, PSYCHOPHYSIOLOGY, V48, P923, DOI 10.1111/j.1469-8986.2010.01154.x
   Fei L, 1996, AM J CARDIOL, V77, P681, DOI 10.1016/S0002-9149(97)89199-0
   Fontenelle LF, 2012, PSYCHIAT RES, V199, P195, DOI 10.1016/j.psychres.2012.03.034
   Friedman BH, 2007, BIOL PSYCHOL, V74, P185, DOI 10.1016/j.biopsycho.2005.08.009
   Goldberger JJ, 2001, CIRCULATION, V103, P1977
   Gorman Jack M., 2000, American Heart Journal, V140, pS77
   Govoni S, 2011, PHARMACOL RES, V63, P266, DOI 10.1016/j.phrs.2010.12.017
   Hazari MS, 2007, AM J PHYSIOL-LUNG C, V292, pL992, DOI 10.1152/ajplung.00216.2006
   Hudson JL, 2013, J CHILD PSYCHOL PSYC, V54, P1086, DOI 10.1111/jcpp.12092
   Jockers-Scherübl MC, 2007, PROG NEURO-PSYCHOPH, V31, P200, DOI 10.1016/j.pnpbp.2006.09.006
   Kaur G, 2007, BRAIN RES, V1139, P6, DOI 10.1016/j.brainres.2006.12.084
   Kreusser MM, 2008, J MOL CELL CARDIOL, V44, P380, DOI 10.1016/j.yjmcc.2007.10.019
   Lang UE, 2008, PHARMACOPSYCHIATRY, V41, P196, DOI 10.1055/s-0028-1082070
   Laurent HK, 2013, PSYCHOSOM MED, V75, P744, DOI 10.1097/PSY.0b013e3182a85ffd
   Lester KJ, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.33
   LEVIMONTALCINI R, 1987, SCIENCE, V237, P1154, DOI 10.1126/science.3306916
   Lin Y.C., 2000, Beck anxiety inventory (Chinese version)
   Lipov E, 2012, MED HYPOTHESES, V79, P750, DOI 10.1016/j.mehy.2012.08.019
   Lipps BV, 2002, J NAT TOXINS, V11, P387
   Liu CC, 2003, AM J PHYSIOL-HEART C, V285, pH2188, DOI 10.1152/ajpheart.00256.2003
   Livak KJ, 1999, GENET ANAL-BIOMOL E, V14, P143, DOI 10.1016/S1050-3862(98)00019-9
   LOWN B, 1976, NEW ENGL J MED, V294, P1165
   MALLIANI A, 1991, CIRCULATION, V84, P482, DOI 10.1161/01.CIR.84.2.482
   Martens EJ, 2008, PSYCHOL MED, V38, P375, DOI 10.1017/S0033291707002097
   Melzig CA, 2009, INT J PSYCHOPHYSIOL, V71, P109, DOI 10.1016/j.ijpsycho.2008.07.013
   MEREDITH IT, 1991, NEW ENGL J MED, V325, P618, DOI 10.1056/NEJM199108293250905
   Miu AC, 2009, AUTON NEUROSCI-BASIC, V145, P99, DOI 10.1016/j.autneu.2008.11.010
   MONTANO N, 1994, CIRCULATION, V90, P1826, DOI 10.1161/01.CIR.90.4.1826
   Neumann SA, 2005, PSYCHOSOM MED, V67, P168, DOI 10.1097/01.psy.0000155671.90861.c2
   Pongrac JL, 1996, J NEUROCHEM, V66, P804
   Ponikowski P, 1997, AM J CARDIOL, V79, P1645, DOI 10.1016/S0002-9149(97)00215-4
   Roest AM, 2010, J AM COLL CARDIOL, V56, P38, DOI 10.1016/j.jacc.2010.03.034
   Sandercock GRH, 2005, INT J CARDIOL, V103, P238, DOI 10.1016/j.ijcard.2004.09.013
   SATO N, 1995, PSYCHOSOM MED, V57, P331, DOI 10.1097/00006842-199507000-00004
   Serrano T, 1996, NEUROREPORT, V8, P179, DOI 10.1097/00001756-199612200-00036
   Servant D, 2009, ENCEPHALE, V35, P423, DOI 10.1016/j.encep.2008.06.016
   Sheehan DV, 1998, J CLIN PSYCHIAT, V59, P22, DOI 10.4088/JCP.09m05305whi
   Singh JP, 2001, AUTON NEUROSCI-BASIC, V90, P122, DOI 10.1016/S1566-0702(01)00277-6
   Singh JP, 1999, CIRCULATION, V99, P2251, DOI 10.1161/01.CIR.99.17.2251
   Squillacioti C, 2009, EUR J HISTOCHEM, V53, P239, DOI 10.4081/ejh.2009.e29
   Syed Z, 2007, AM J MED GENET B, V144B, P375, DOI 10.1002/ajmg.b.30459
   Tsuji H, 1996, CIRCULATION, V94, P2850, DOI 10.1161/01.CIR.94.11.2850
   Yang AC, 2010, AM J MED GENET B, V153B, P1024, DOI 10.1002/ajmg.b.31069
   Yee BK, 2007, J NEURAL TRANSM, V114, P431, DOI 10.1007/s00702-006-0548-9
   Zhu SW, 2006, BEHAV BRAIN RES, V169, P10, DOI 10.1016/j.bbr.2005.11.024
NR 60
TC 20
Z9 20
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD OCT
PY 2014
VL 76
IS 8
BP 638
EP 643
DI 10.1097/PSY.0000000000000091
PG 6
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA AR9HK
UT WOS:000343883900008
PM 25162994
DA 2025-06-11
ER

PT J
AU Yoon, J
   Kim, J
   Son, H
AF Yoon, Jaehee
   Kim, Jeewuan
   Son, Heesook
TI Gender Differences of Health Behaviors in the Risk of Metabolic Syndrome
   for Middle-Aged Adults: A National Cross-Sectional Study in South Korea
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE gender differences; metabolic syndrome; health practice index;
   middle-aged
AB This study examined gender differences in health behaviors for the risk of metabolic syndrome (MetS) among middle-aged adults using nationally representative data from the Seventh Korea National Health and Nutrition Examination Survey (2016-2018). The sample included data from 8677 middle-aged adults. The Health Practice Index measured health behaviors, including smoking, alcohol use, physical activity, sleeping, eating breakfast, working hours, nutritionally balanced diet, and mental stress. Complex sample multiple logistic regression analyses were conducted to determine the association between the Health Practice Index (HPI) and MetS. Men and women with poor or moderate HPI scores had significantly higher risks of having MetS than those with good HPI scores. Controlling for covariates, high-risk alcohol use (p < 0.001) and physical activity (p = 0.008) were associated with the risk of MetS in men and women, respectively. Men reporting alcohol use and women lacking a healthy diet were, respectively, 2.056 times (adjusted odds ratio (OR) = 2.056, 95% CI: 1.681-2.514) and 1.306 times (adjusted OR = 1.306, 95% CI: 1.075-1.587) more likely to have increased risks of MetS. Given these gender differences in health behaviors, developing tailored interventions could be beneficial in preventing MetS among middle-aged men and women.
C1 [Yoon, Jaehee] Wolchon Elementary Sch, Seoul 07980, South Korea.
   [Kim, Jeewuan] Yonsei Univ, Dept Stat & Data Sci, Seoul 03722, South Korea.
   [Son, Heesook] Chung Ang Univ, Red Cross Coll Nursing, Seoul 06974, South Korea.
C3 Yonsei University; Chung Ang University
RP Son, H (corresponding author), Chung Ang Univ, Red Cross Coll Nursing, Seoul 06974, South Korea.
EM rnyjh@snu.ac.kr; jeewuan@yonsei.ac.kr; hson@cau.ac.kr
RI Yoon, Jaehee/AAP-1159-2021
OI YOON, JAEHEE/0000-0001-9826-8408
FU National Research Foundation of Korea Grant - Korean Government
   [NRF-2019R1A2C1006716]
FX This work was supported by a National Research Foundation of Korea Grant
   funded by the Korean Government (NRF-2019R1A2C1006716).
CR Ajlouni K, 2020, DIABETOL METAB SYNDR, V12, DOI 10.1186/s13098-020-00610-7
   Amirfaiz S, 2019, METAB SYNDR RELAT D, V17, P1, DOI 10.1089/met.2018.0032
   [Anonymous], 2019, MAJ RES HLTH BEH
   [Anonymous], 2016, GUIDELINES USE 7 KOR
   Beigh SH, 2012, BIOINFORMATION, V8, P613, DOI 10.6026/97320630008613
   Bohr AD, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-2964-6
   Buscemi S, 2014, EAT WEIGHT DISORD-ST, V19, P225, DOI 10.1007/s40519-014-0117-4
   Chen YC, 2010, J CLIN NURS, V19, P3031, DOI 10.1111/j.1365-2702.2010.03280.x
   Cho Young Kyung, 2019, Korean Journal of Family Practice, V9, P373, DOI 10.21215/kjfp.2019.9.4.373
   Choi S, 2019, DIABETES METAB J, V43, P615, DOI 10.4093/dmj.2018.0128
   de Lorgeril M, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-139
   Djousse L., 2010, Endocrine Metabolic & Immune Disorders-Drug Targets, V10, P124
   Dronina Yuliya, 2016, J Lifestyle Med, V6, P16, DOI 10.15280/jlm.2016.6.1.16
   Fabiani R, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092056
   Fujita N, 2011, HEPATOL RES, V41, P287, DOI 10.1111/j.1872-034X.2011.00787.x
   Gomez-Huelgas R, 2015, EUR J INTERN MED, V26, P317, DOI 10.1016/j.ejim.2015.04.007
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hamaguchi M, 2012, WORLD J GASTROENTERO, V18, P156, DOI 10.3748/wjg.v18.i2.156
   Hattori T, 2017, INTERNAL MED, V56, P2253, DOI 10.2169/internalmedicine.8578-16
   Henning-Smith C, 2020, J APPL GERONTOL, V39, P971, DOI 10.1177/0733464819835113
   Huang PX, 2009, PREV MED, V48, P383, DOI 10.1016/j.ypmed.2008.12.023
   Jahangiry L, 2015, TRIALS, V16, DOI 10.1186/s13063-015-0950-4
   Ju SY, 2013, NUTR DIABETES, V3, DOI 10.1038/nutd.2013.8
   Julibert A, 2019, NUTR METAB CARDIOVAS, V29, P887, DOI 10.1016/j.numecd.2019.05.055
   Kang Y, 2016, EUR J NUTR, V55, P2321, DOI 10.1007/s00394-015-1127-3
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Kim HyunKyung Kim HyunKyung, 2019, Journal of Nutrition and Health, V52, P435, DOI 10.4163/jnh.2019.52.5.435
   KUSAKA Y, 1992, PREV MED, V21, P602, DOI 10.1016/0091-7435(92)90068-S
   Lee G, 2015, J KOREAN ACAD NURS, V45, P483, DOI 10.4040/jkan.2015.45.4.483
   Lee K, 2012, PUBLIC HEALTH NUTR, V15, P1917, DOI 10.1017/S136898001100365X
   Lee M, 2019, BRIT J NUTR, V122, P723, DOI 10.1017/S000711451900165X
   Lee SY, 2007, DIABETES RES CLIN PR, V75, P72, DOI 10.1016/j.diabres.2006.04.013
   Lee SE, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194490
   Lin KM, 2019, BIOL RES NURS, V21, P173, DOI 10.1177/1099800418816175
   Meher T, 2020, CLIN EPIDEMIOL GLOB, V8, P1047, DOI 10.1016/j.cegh.2020.03.018
   Ministry of Health and Welfare, 2020, TREND REP 4 NAT HLTH
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Pucci G, 2017, PHARMACOL RES, V120, P34, DOI 10.1016/j.phrs.2017.03.008
   Ryu H, 2017, ARCH ENVIRON OCCUP H, V72, P249, DOI 10.1080/19338244.2016.1200004
   Sakane N, 2019, METAB SYNDR RELAT D, V17, P355, DOI 10.1089/met.2018.0130
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Shin D, 2018, INT J CARDIOL, V259, P216, DOI 10.1016/j.ijcard.2018.01.139
   Smith KW, 2020, ETHNIC DIS, V30, P331, DOI 10.18865/ed.30.2.331
   Sun K, 2014, CLIN NUTR, V33, P596, DOI 10.1016/j.clnu.2013.10.003
   Tian X, 2017, ONCOTARGET, V8, P73568, DOI 10.18632/oncotarget.20625
   Wada T, 2009, INTERNAL MED, V48, P647, DOI 10.2169/internalmedicine.48.1824
   Wang WY, 2020, J CARDIOVASC NURS, V35, P502, DOI 10.1097/JCN.0000000000000714
   Wong EML, 2020, J ADV NURS, V76, P364, DOI 10.1111/jan.14241
   Wu HY, 2010, J NUTR, V140, P1937, DOI 10.3945/jn.110.126300
   Xu SH, 2016, NUTRIENTS, V8, DOI 10.3390/nu8040180
   Yamamoto K, 2011, J PHYSIOL ANTHROPOL, V30, P15, DOI 10.2114/jpa2.30.15
   Yoon Nan-He, 2014, Osong Public Health Res Perspect, V5, P370, DOI 10.1016/j.phrp.2014.10.005
   Zhang DD, 2017, METABOLISM, V75, P36, DOI 10.1016/j.metabol.2017.08.001
NR 54
TC 6
Z9 6
U1 1
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD APR
PY 2021
VL 18
IS 7
AR 3699
DI 10.3390/ijerph18073699
PG 16
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA RK8EM
UT WOS:000638522400001
PM 33916247
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gonçalves, AS
   Andrade, N
   Martel, F
AF Goncalves, Ana S.
   Andrade, Nelson
   Martel, Fatima
TI Intestinal fructose absorption: Modulation and relation to human
   diseases
SO PHARMANUTRITION
LA English
DT Article
DE Fructose; Intestinal absorption; GLUT5; GLUT2; Metabolic syndrome;
   Cancer
ID AGE-ASSOCIATED CHANGES; RAT SMALL-INTESTINE; DIETARY FRUCTOSE;
   MESSENGER-RNA; METABOLIC SYNDROME; OXIDATIVE STRESS; HIGH-FAT;
   ADIPOSE-TISSUE; CORN SYRUP; URIC-ACID
AB Background: Fructose is a hexose sugar found naturally in our diet and excessive fructose consumption has been documented in humans over the last decades. Fructose absorption in the small intestine is a highly regulated process and GLUT5 plays an essential role in this process, but GLUT2 is also involved.
   Methods: In this review, we will describe the multiple mechanisms involved in the regulation of intestinal fructose absorption and the effects of excessive consumption of this sugar on human health.
   Results: Excessive fructose intake is associated with a growing incidence of certain diseases, including obesity, type 2 diabetes, non-alcoholic fatty liver disease, cardiac disease, gastrointestinal disorders, and cancer. It is also associated with changes in gut integrity and microbiota.
   Conclusions: High fructose consumption is associated with the development of characteristics of metabolic syndrome and of other diseases such as cardiomyopathies, kidney disease and tumor growth, in both humans and rodents So, modulation of GLUT5and/or GLUT2-mediated intestinal fructose absorption might provide a novel pharmacologic strategy for the treatment of these diseases. However, most of the data on high fructose consumption has been obtained in rodent models, and so more studies are needed in order to fully confirm these observations in humans.
C1 [Goncalves, Ana S.; Andrade, Nelson; Martel, Fatima] Univ Porto, Fac Med, Unit Biochem, Dept Biomed, P-4200319 Porto, Portugal.
   [Andrade, Nelson; Martel, Fatima] Univ Porto, Inst Invest & Inovacao Saude i3S, Porto, Portugal.
   [Andrade, Nelson] Univ Porto, Fac Pharm, Dept Chem Sci, REQUIMTE LAQV, Porto, Portugal.
C3 Universidade do Porto; Universidade do Porto; i3S - Instituto de
   Investigacao e Inovacao em Saude, Universidade do Porto; Universidade do
   Porto
RP Martel, F (corresponding author), Univ Porto, Fac Med, Unit Biochem, Dept Biomed, P-4200319 Porto, Portugal.
EM fmartel@med.up.pt
RI Andrade, Nelson/AAK-3763-2021; Martel, Felix/JFJ-0587-2023; Gonçalves,
   ana/JJF-8262-2023
OI Martel, Fatima/0000-0002-0525-3416; Andrade, Nelson/0000-0003-2600-8599
FU FCT-Fundacao para a Ciencia e a Tecnologia (Instituto de Investigacao e
   Inovacao em Saude, Universidade do Porto, Portugal)
   [(UID/BIM/04293/2013)]
FX F. Martel acknowledges funding from FCT-Fundacao para a Ciencia e a
   Tecnologia (Instituto de Investigacao e Inovacao em Saude, Universidade
   do Porto, Portugal (UID/BIM/04293/2013)).
CR Affleck JA, 2003, J HISTOCHEM CYTOCHEM, V51, P1567, DOI 10.1177/002215540305101116
   Ait-Omar A, 2011, DIABETES, V60, P2598, DOI 10.2337/db10-1740
   Al Maskari Masoud Y, 2006, Sultan Qaboos Univ Med J, V6, P27
   Alavi K, 2002, J PEDIATR SURG, V37, P327, DOI 10.1053/jpsu.2002.30805
   Almenara CCP, 2015, TOXICOL IN VITRO, V29, P2030, DOI 10.1016/j.tiv.2015.08.013
   Alzamendi A, 2009, ENDOCRINE, V35, P227, DOI 10.1007/s12020-008-9143-1
   Andrade N, 2019, FOOD FUNCT, V10, P4566, DOI [10.1039/c9fo01142k, 10.1039/C9FO01142K]
   Andrade N, 2020, EUR J NUTR, V59, P151, DOI 10.1007/s00394-019-01895-9
   Andrade N, 2018, TOXICOL RES-UK, V7, P1236, DOI 10.1039/c8tx00183a
   Andrade N, 2017, J FUNCT FOODS, V36, P429, DOI 10.1016/j.jff.2017.07.032
   Babbar L, 2013, N-S ARCH PHARMACOL, V386, P319, DOI 10.1007/s00210-012-0830-3
   Barone S, 2009, J BIOL CHEM, V284, P5056, DOI 10.1074/jbc.M808128200
   Barrenetxe J, 2013, CYTOKINE, V64, P181, DOI 10.1016/j.cyto.2013.07.004
   Bergheim I, 2008, J HEPATOL, V48, P983, DOI 10.1016/j.jhep.2008.01.035
   Bray GA, 2004, AM J CLIN NUTR, V79, P537
   BURANT CF, 1994, AM J PHYSIOL, V267, pG71, DOI 10.1152/ajpgi.1994.267.1.G71
   BURANT CF, 1992, J BIOL CHEM, V267, P14523
   CASTELLO A, 1995, BIOCHEM J, V309, P271, DOI 10.1042/bj3090271
   CHEESEMAN CI, 1993, GASTROENTEROLOGY, V105, P1050, DOI 10.1016/0016-5085(93)90948-C
   Chen G, 2016, PHARMACOL REP, V68, P782, DOI 10.1016/j.pharep.2016.04.014
   Chen HD, 2017, INT J CLIN EXP PATHO, V10, P4852
   Chen WL, 2016, CANCER CELL, V30, P779, DOI 10.1016/j.ccell.2016.09.006
   Cioffi F, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040323
   Considine RV, 1996, NEW ENGL J MED, V334, P292, DOI 10.1056/NEJM199602013340503
   Corpe CP, 1996, PFLUG ARCH EUR J PHY, V432, P192, DOI 10.1007/s004240050124
   Corpe CP, 1996, AM J PHYSIOL-GASTR L, V271, pG211, DOI 10.1152/ajpgi.1996.271.1.G211
   CSAKY TZ, 1984, BIOCHIM BIOPHYS ACTA, V772, P259, DOI 10.1016/0005-2736(84)90142-1
   Cui XL, 2005, AM J PHYSIOL-GASTR L, V288, pG1310, DOI 10.1152/ajpgi.00550.2004
   Cui XL, 2004, J NUTR, V134, P1697, DOI 10.1093/jn/134.7.1697
   Cui XL, 2003, BBA-BIOMEMBRANES, V1612, P178, DOI 10.1016/S0005-2736(03)00129-9
   Darakhshan F, 1998, BIOCHEM J, V336, P361, DOI 10.1042/bj3360361
   DAVID ES, 1995, PEDIATR RES, V37, P777, DOI 10.1203/00006450-199506000-00017
   Davids MR, 2004, QJM-INT J MED, V97, P365, DOI 10.1093/qjmed/hch064
   Delie F, 1997, CRIT REV THER DRUG, V14, P221
   Di Luccia B, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0134893
   Do MH, 2018, NUTRIENTS, V10, DOI 10.3390/nu10060761
   Dornas WC, 2015, ADV NUTR, V6, P729, DOI 10.3945/an.114.008144
   Dotimas JR, 2016, ELIFE, V5, DOI 10.7554/eLife.18313
   Douard V, 2008, J PHYSIOL-LONDON, V586, P3657, DOI 10.1113/jphysiol.2008.155226
   Douard V, 2008, ENDOCRINOLOGY, V149, P409, DOI 10.1210/en.2007-0906
   Douard V, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0093611
   Douard V, 2013, J PHYSIOL-LONDON, V591, P401, DOI 10.1113/jphysiol.2011.215731
   Douard V, 2010, J AM SOC NEPHROL, V21, P261, DOI 10.1681/ASN.2009080795
   Drozdowski L, 2005, AM J PHYSIOL-GASTR L, V288, pG125, DOI 10.1152/ajpgi.00311.2003
   Drozdowskia LA, 2004, J NUTR BIOCHEM, V15, P630, DOI 10.1016/j.jnutbio.2004.06.003
   Dyer J, 2002, AM J PHYSIOL-GASTR L, V282, pG241, DOI 10.1152/ajpgi.00310.2001
   Fan XJ, 2017, PEERJ, V5, DOI 10.7717/peerj.3804
   Ferraris RP, 2018, ANNU REV NUTR, V38, P41, DOI 10.1146/annurev-nutr-082117-051707
   FERRARIS RP, 1993, DIABETES, V42, P1579, DOI 10.2337/diabetes.42.11.1579
   Francini F, 2010, LIFE SCI, V86, P965, DOI 10.1016/j.lfs.2010.05.005
   García-Barrios A, 2010, J CELL BIOCHEM, V111, P1321, DOI 10.1002/jcb.22859
   García-Herrera J, 2004, CYTOKINE, V25, P21, DOI 10.1016/j.cyto.2003.09.005
   García-Herrera J, 2008, AM J PHYSIOL-GASTR L, V294, pG155, DOI 10.1152/ajpgi.00139.2007
   Gersch MS, 2007, AM J PHYSIOL-RENAL, V293, pF1256, DOI 10.1152/ajprenal.00181.2007
   Goncalves MD, 2019, SCIENCE, V363, P1345, DOI 10.1126/science.aat8515
   Gouyon F, 2003, J PHYSIOL-LONDON, V552, P823, DOI 10.1113/jphysiol.2003.049247
   Gouyon F, 2003, BIOCHEM J, V375, P167, DOI 10.1042/BJ20030661
   Hanousková B, 2019, J NUTR BIOCHEM, V68, P42, DOI 10.1016/j.jnutbio.2019.03.001
   Helliwell PA, 2000, BIOCHEM J, V350, P163, DOI 10.1042/0264-6021:3500163
   Helliwell PA, 2000, BIOCHEM J, V350, P149, DOI 10.1042/0264-6021:3500149
   Helliwell PA, 2003, J BIOL CHEM, V278, P28644, DOI 10.1074/jbc.M301479200
   Huang BW, 2004, DIABETES OBES METAB, V6, P120, DOI 10.1111/j.1462-8902.2004.00323.x
   Huang JP, 2016, INT J CARDIOL, V215, P65, DOI 10.1016/j.ijcard.2016.03.239
   Ibrahim SM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0117516
   Iizuka K, 2004, P NATL ACAD SCI USA, V101, P7281, DOI 10.1073/pnas.0401516101
   Iizuka K, 2017, NUTRIENTS, V9, DOI 10.3390/nu9020181
   INUKAI K, 1993, ENDOCRINOLOGY, V133, P2009, DOI 10.1210/en.133.5.2009
   Jang C, 2018, CELL METAB, V27, P351, DOI 10.1016/j.cmet.2017.12.016
   Jegatheesan P., 2016, CLIN NUTR, V35
   Jena PrasantKumar., 2016, INFLUENCE GUT MICROB, V12, P109, DOI DOI 10.4172/1745-7580.10000109
   Jiang L, 2001, AM J PHYSIOL-GASTR L, V281, pG666, DOI 10.1152/ajpgi.2001.281.3.G666
   Jiang L, 2001, AM J PHYSIOL-GASTR L, V280, pG113, DOI 10.1152/ajpgi.2001.280.1.G113
   Jin CP, 2019, ONCOTARGETS THER, V12, P5425, DOI 10.2147/OTT.S205522
   Jin X, 2019, CELL BIOL TOXICOL, V35, P471, DOI 10.1007/s10565-019-09478-4
   Johnson RJ, 2018, BMC NEPHROL, V19, DOI 10.1186/s12882-018-1105-0
   Johnson RJ, 2013, J EQUINE VET SCI, V33, P120, DOI 10.1016/j.jevs.2012.05.004
   Jones HF, 2011, J PEDIATR GASTR NUTR, V52, P581, DOI 10.1097/MPG.0b013e3181fd1315
   Jürgens H, 2005, OBES RES, V13, P1146, DOI 10.1038/oby.2005.136
   Kamide K, 2002, AM J HYPERTENS, V15, P66, DOI 10.1016/S0895-7061(01)02232-4
   Kawasaki T, 2009, J NUTR, V139, P2067, DOI 10.3945/jn.109.105858
   KAYANO T, 1990, J BIOL CHEM, V265, P13276
   Kerimi A, 2019, BRIT J NUTR, V121, P782, DOI 10.1017/S0007114519000084
   Kim H, 2019, CELL MOL LIFE SCI, V76, P4341, DOI 10.1007/s00018-019-03114-4
   Kim M, 2017, JCI INSIGHT, V2, DOI 10.1172/jci.insight.96703
   Kishi K, 1999, J NUTR, V129, P953, DOI 10.1093/jn/129.5.953
   Koliada A, 2017, BMC MICROBIOL, V17, DOI 10.1186/s12866-017-1027-1
   Lambertz J, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01159
   Lee Y, 2015, MOLECULES, V20, P17393, DOI 10.3390/molecules200917393
   Lima KM, 2017, J BIOL CHEM, V292, P13758, DOI 10.1074/jbc.M117.800391
   MAHRAOUI L, 1994, BIOCHEM J, V301, P169, DOI 10.1042/bj3010169
   Marvasti F. Ettehad, 2019, IRAN BIOMED J
   Mastrocola R, 2018, J NUTR BIOCHEM, V55, P185, DOI 10.1016/j.jnutbio.2018.02.003
   Masuy I, 2018, NEUROGASTROENT MOTIL, V30, DOI 10.1111/nmo.13167
   Merino B, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010094
   Miller A, 2008, CURR OPIN GASTROEN, V24, P204, DOI 10.1097/MOG.0b013e3282f3f4c4
   MIYAMOTO K, 1993, BIOCHEM J, V295, P211, DOI 10.1042/bj2950211
   MIYAMOTO K, 1991, BIOCHEM BIOPH RES CO, V181, P1110, DOI 10.1016/0006-291X(91)92053-M
   Mochizuki K, 2007, BIOSCI BIOTECH BIOCH, V71, P1345, DOI 10.1271/bbb.70014
   Mochizuki K, 2007, BBA-GEN SUBJECTS, V1770, P609, DOI 10.1016/j.bbagen.2006.12.011
   Moonishaa Thiyagarajan Manjuladevi, 2017, Int J Appl Basic Med Res, V7, P176, DOI 10.4103/ijabmr.IJABMR_278_16
   Nakagawa T, 2006, AM J PHYSIOL-RENAL, V290, pF625, DOI 10.1152/ajprenal.00140.2005
   Nobigrot T, 1997, J AM COLL NUTR, V16, P152
   Nyby MD, 2007, HYPERTENS RES, V30, P451, DOI 10.1291/hypres.30.451
   Obi IE, 2011, J EXP BIOL, V214, P2337, DOI 10.1242/jeb.055095
   Odegaard AO, 2012, OBESITY, V20, P689, DOI 10.1038/oby.2011.277
   Oh AR, 2018, METABOLISM, V85, P286, DOI 10.1016/j.metabol.2018.04.006
   Oudot A, 2009, PHYSIOL RES, V58, P499, DOI 10.33549/physiolres.931583
   Fariña JP, 2013, CLIN SCI, V125, P87, DOI 10.1042/CS20120470
   Palavicino-Maggio CB, 2016, SCHIZOPHRENIA BULL, V42, P1270, DOI 10.1093/schbul/sbw037
   Patel C, 2015, FASEB J, V29, P4046, DOI 10.1096/fj.15-272195
   Payne AN, 2012, OBES REV, V13, P799, DOI 10.1111/j.1467-789X.2012.01009.x
   Pearson PY, 2001, J SURG RES, V97, P192, DOI 10.1006/jsre.2001.6153
   Porto ML, 2015, TOXICOL IN VITRO, V29, P1977, DOI 10.1016/j.tiv.2015.08.006
   Prakash P, 2011, CARDIOVASC DRUG THER, V25, P285, DOI 10.1007/s10557-011-6312-x
   RAND EB, 1993, AM J PHYSIOL, V264, pG1169, DOI 10.1152/ajpgi.1993.264.6.G1169
   Rezaeimanesh N, 2019, MULT SCLER RELAT DIS, V31, P112, DOI 10.1016/j.msard.2019.03.028
   Rho YH, 2011, SEMIN NEPHROL, V31, P410, DOI 10.1016/j.semnephrol.2011.08.004
   Rippe JM, 2013, ADV NUTR, V4, P236, DOI 10.3945/an.112.002824
   Ritze Y, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0101702
   Riva A, 2017, ENVIRON MICROBIOL, V19, P95, DOI 10.1111/1462-2920.13463
   Roche M, 2010, AM J PHYSIOL-REG I, V298, pR173, DOI 10.1152/ajpregu.00612.2009
   Rosas-Villegas A, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040393
   Sakar Y, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007935
   Sandeva R, 2015, J BIOMED CLIN RES, V8
   Satsu H, 2018, BIOSCI BIOTECH BIOCH, V82, P636, DOI 10.1080/09168451.2017.1387515
   Sellmann C, 2015, J NUTR BIOCHEM, V26, P1183, DOI 10.1016/j.jnutbio.2015.05.011
   Shaligram S, 2018, J NUTR BIOCHEM, V57, P136, DOI 10.1016/j.jnutbio.2018.03.021
   Shapiro A, 2008, AM J PHYSIOL-REG I, V295, pR1370, DOI 10.1152/ajpregu.00195.2008
   Shepherd SJ, 2008, CLIN GASTROENTEROL H, V6, P765, DOI 10.1016/j.cgh.2008.02.058
   Shu R, 1997, AM J PHYSIOL-GASTR L, V272, pG446, DOI 10.1152/ajpgi.1997.272.3.G446
   Singh AK, 2008, KIDNEY INT, V74, P438, DOI 10.1038/ki.2008.184
   Spruss A, 2012, LAB INVEST, V92, P1020, DOI 10.1038/labinvest.2012.75
   Steenson S, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040349
   Su CH, 2018, BIOCHEM BIOPH RES CO, V500, P462, DOI 10.1016/j.bbrc.2018.04.103
   Suzuki T, 2011, BIOCHEM J, V435, P43, DOI 10.1042/BJ20101987
   Tappy L, 2018, J EXP BIOL, V221, DOI 10.1242/jeb.164202
   Tappy L, 2010, PHYSIOL REV, V90, P23, DOI 10.1152/physrev.00019.2009
   Taskinen MR, 2019, NUTRIENTS, V11, DOI 10.3390/nu11091987
   Tavernier A, 2014, FASEB J, V28, P4100, DOI 10.1096/fj.14-255158
   Taylor EN, 2008, KIDNEY INT, V73, P207, DOI 10.1038/sj.ki.5002588
   Teixeira TFS, 2012, CLIN NUTR, V31, P735, DOI 10.1016/j.clnu.2012.02.009
   Thiesen A, 2003, DIGEST DIS SCI, V48, P2196, DOI 10.1023/B:DDAS.0000004526.40310.cc
   Thiesen A, 2003, J APPL PHYSIOL, V94, P583, DOI 10.1152/japplphysiol.00134.2002
   Tobin V, 2008, DIABETES, V57, P555, DOI 10.2337/db07-0928
   Toop CR, 2016, NUTRIENTS, V8, DOI 10.3390/nu8090577
   Verma S, 1999, EUR J PHARMACOL, V373, pR1, DOI 10.1016/S0014-2999(99)00301-5
   Verma S, 1995, AM J PHYSIOL-HEART C, V269, pH2017, DOI 10.1152/ajpheart.1995.269.6.H2017
   Villa-Rodriguez JA, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201700566
   Volynets V, 2017, J NUTR, V147, P770, DOI 10.3945/jn.116.242859
   Walder K, 1997, J ENDOCRINOL, V155, pR5, DOI 10.1677/joe.0.155R005
   Weng YY, 2018, CELL DEATH DISCOV, V4, DOI 10.1038/s41420-018-0038-5
   Wong SK, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0123-9
   Wright EM, 2003, BEST PRACT RES CL GA, V17, P943, DOI 10.1016/S1521-6918(03)00107-0
   Zhai XC, 2017, FOOD FUNCT, V8, P2536, DOI [10.1039/c7fo00490g, 10.1039/C7FO00490G]
   Zwarts I, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-45803-x
NR 155
TC 4
Z9 4
U1 3
U2 18
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-4344
J9 PHARMANUTRITION
JI PharmaNutrition
PD DEC
PY 2020
VL 14
AR 100235
DI 10.1016/j.phanu.2020.100235
PG 9
WC Chemistry, Medicinal; Geriatrics & Gerontology; Gerontology; Nutrition &
   Dietetics; Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy; Geriatrics & Gerontology; Nutrition & Dietetics
GA PE2DL
UT WOS:000598179700006
DA 2025-06-11
ER

PT J
AU Ramirez-Higuera, A
   Quevedo-Corona, L
   Paniagua-Castro, N
   Chamorro-Ceballos, G
   Milliar-Garcia, A
   Jaramillo-Flores, ME
AF Ramirez-Higuera, Abril
   Quevedo-Corona, Lucia
   Paniagua-Castro, Norma
   Chamorro-Ceballos, German
   Milliar-Garcia, Angel
   Jaramillo-Flores, Maria E.
TI Antioxidant enzymes gene expression and antihypertensive effects of
   seaweeds Ulva linza and Lessonia trabeculata in rats fed a
   high-fat and high-sucrose diet
SO JOURNAL OF APPLIED PHYCOLOGY
LA English
DT Article
DE Ulva linza; Lessonia trabeculata; Chlorophyta; Phaeophyta; Metabolic
   syndrome; Hypertension; Gene expression
ID METABOLIC SYNDROME; OXIDATIVE STRESS; LIPID-METABOLISM; OBESITY;
   FUCOXANTHIN; GLUCOSE; EXTRACT
AB The objective of this work was to evaluate the antihypertensive and antioxidant effect of seaweeds (Ulva linza and Lessonia trabeculata) in rats which were fed a hypercaloric diet. Seaweed at 400 mg kg(-1) of body weight was administered for 8 weeks to Wistar rats that were fed with a standard diet or a hypercaloric diet. Intra-abdominal fat, insulin resistance, and lipid profile of the rats were determined. Liver was isolated to determine antioxidant enzymes [superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)] activity and gene expression. The administration of seaweed to the rats reduced the levels of intra-abdominal fat, arterial blood pressure, insulin resistance, and cholesterol and triglyceride serum levels. U. linza reduced the GPx activity in control animals but increased it in animals with MS, which could be reduced by using L. trabeculata. Both seaweeds diminished the SOD and GPx expression and increased CAT in control group. Both seaweeds reduced the CAT expression in animals with metabolic syndrome. Combined effects of the different compounds found in the seaweeds explain the regulating effect over different antioxidant enzymes and metabolic pathways that protect the animals fed a hypercaloric diet against the development of hypertension, hyperglycemia, and obesity.
C1 [Ramirez-Higuera, Abril; Jaramillo-Flores, Maria E.] Escuela Nacl Ciencias Biolg, Inst Politecn Nacl, Casco De Santo Tomas 11340, Mexico.
   [Quevedo-Corona, Lucia; Paniagua-Castro, Norma] Escuela Nacl Ciencias Biolg, Inst Politecn Nacl, Dept Fisiol, Casco De Santo Tomas 11340, Mexico.
   [Chamorro-Ceballos, German] Escuela Nacl Ciencias Biolg, Inst Politecn Nacl, Dept Farm, Casco De Santo Tomas 11340, Mexico.
   [Milliar-Garcia, Angel] Escuela Nacl Ciencias Biolg, Inst Politecn Nacl, Secc Estudios Posgrad & Invest, Casco De Santo Tomas 11340, Mexico.
C3 Instituto Politecnico Nacional - Mexico; Instituto Politecnico Nacional
   - Mexico; Instituto Politecnico Nacional - Mexico; Instituto Politecnico
   Nacional - Mexico
RP Jaramillo-Flores, ME (corresponding author), Escuela Nacl Ciencias Biolg, Inst Politecn Nacl, Carpio Plan Ayala S-N, Casco De Santo Tomas 11340, Mexico.
EM Jaramillo_flores@hotmail.com
FU SIP/IPN; SCYTDF [SIP20131019, SIP20131172, SIP20131522, PICSA12-036];
   PIFI, CONACYT
FX The authors would like to acknowledge SIP/IPN and SCYTDF (grant
   SIP20131019; SIP20131172; SIP20131522; PICSA12-036) for the financial
   support. ARH is grateful to PIFI, CONACYT for a graduate scholarship.
   LQ, NPC, HR, AMG, and MEJ are SNI, EDI/IPN, and COFAA/IPN fellows.
CR Amengual J, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020644
   Barrientos C, 2010, NUTR RES, V30, P791, DOI 10.1016/j.nutres.2010.10.008
   Chen H, 2010, FOOD CHEM, V119, P1633, DOI 10.1016/j.foodchem.2009.09.056
   Denis C, 2010, FOOD CHEM, V119, P913, DOI 10.1016/j.foodchem.2009.07.047
   Ghosh S, 2011, J BIOL CHEM, V286, P42483, DOI 10.1074/jbc.M111.304592
   Gupta S, 2011, TRENDS FOOD SCI TECH, V22, P315, DOI 10.1016/j.tifs.2011.03.011
   Jeon SM, 2010, BIOTECHNOL J, V5, P961, DOI 10.1002/biot.201000215
   Jung HA, 2006, FISHERIES SCI, V72, P1292, DOI 10.1111/j.1444-2906.2006.01288.x
   Jung UJ, 2008, CLIN NUTR, V27, P158, DOI 10.1016/j.clnu.2007.09.009
   Li B, 2008, MOLECULES, V13, P1671, DOI 10.3390/molecules13081671
   Meenakshi S., 2009, Glob J Pharmacol, V3, P59
   Mohamed S, 2012, TRENDS FOOD SCI TECH, V23, P83, DOI 10.1016/j.tifs.2011.09.001
   Noeman SA, 2011, DIABETOL METAB SYNDR, V3, DOI 10.1186/1758-5996-3-17
   Pedro-Botet J, 2000, J HUM HYPERTENS, V14, P343, DOI 10.1038/sj.jhh.1001034
   Styskal J, 2012, FREE RADICAL BIO MED, V52, P46, DOI 10.1016/j.freeradbiomed.2011.10.441
   Termizy HM, 2009, SINGAP MED J, V50, P390
   Thomas NV, 2011, ENVIRON TOXICOL PHAR, V32, P325, DOI 10.1016/j.etap.2011.09.004
   Vidal Alexis, 2006, Rev. Bras. Cienc. Farm., V42, P589, DOI 10.1590/S1516-93322006000400015
   Woo MN, 2009, MOL NUTR FOOD RES, V53, P1603, DOI 10.1002/mnfr.200900079
   World Health Organization (WHO), Obesity and overweight
   Yang ZH, 2012, DIABETOL METAB SYNDR, V4, DOI 10.1186/1758-5996-4-32
   Yim MJ, 2011, J AGR FOOD CHEM, V59, P1646, DOI 10.1021/jf103290f
NR 22
TC 19
Z9 21
U1 0
U2 50
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0921-8971
EI 1573-5176
J9 J APPL PHYCOL
JI J. Appl. Phycol.
PD FEB
PY 2014
VL 26
IS 1
BP 597
EP 605
DI 10.1007/s10811-013-0134-0
PG 9
WC Biotechnology & Applied Microbiology; Marine & Freshwater Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Marine & Freshwater Biology
GA AA3CF
UT WOS:000330969800063
DA 2025-06-11
ER

PT J
AU Ackerman, Z
   Oron-Herman, M
   Pappo, O
   Peleg, E
   Safadi, R
   Schmilovitz-Weiss, H
   Grozovski, M
AF Ackerman, Zvi
   Oron-Herman, Mor
   Pappo, Orit
   Peleg, Edna
   Safadi, Rifaat
   Schmilovitz-Weiss, Hemda
   Grozovski, Maria
TI Hepatic Effects of Rosiglitazone in Rats with the Metabolic Syndrome
SO BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
LA English
DT Article
ID FATTY LIVER-DISEASE; PLACEBO-CONTROLLED TRIAL; NONALCOHOLIC
   STEATOHEPATITIS; INSULIN-RESISTANCE; OXIDATIVE STRESS; GENE-EXPRESSION;
   ADIPOSE-TISSUE; TROGLITAZONE; MICE; PIOGLITAZONE
AB Rats given fructose-enriched diet develop many characteristics of the human metabolic syndrome and non-alcoholic fatty liver disease. In this study, we characterized the hepatic effects of rosiglitazone in fructose-enriched diet rats. Rats were randomly divided into three groups. One group was maintained on standard rat chow diet for 6 weeks, whereas the other two groups were given fructose-enriched diet for 6 weeks. Four weeks after the initiation of fructose-enriched diet, one of the fructose-enriched diet groups was also given rosiglitazone (10 mg/kg/day) for an additional 2 weeks. Rosiglitazone administration to the fructose-enriched diet rats was associated with decreases in the following parameters: blood pressure (-17%), plasma triglycerides (-62%), hepatic total lipids (-19%), hepatic triglycerides (-61%), hepatic malondialdehyde (-88%), glutathione reductase activity (-84%). An increase in adiponectin plasma levels (+329%), hepatic phospholipids (+46%), hepatic alpha-tocopherol concentrations (+24%) and hepatic paraoxonase activity (+68%) was observed. Rosiglitazone caused a decrease in hepatic macrovesicular steatosis score but no change in hepatic fibrosis. Administration of rosiglitazone, to rats with the metabolic syndrome has limited hepatic favourable effects: it improves hepatic lipid metabolism, decreases macrovesicular steatosis and improves some of the hepatic oxidative-anti-oxidative milieu but has no effect on hepatic fibrosis.
C1 [Ackerman, Zvi] Hadassah Hebrew Univ, Med Ctr, Dept Med, IL-91240 Jerusalem, Israel.
   [Oron-Herman, Mor; Peleg, Edna] Chaim Sheba Med Ctr, Hypertens Unit, IL-52621 Tel Hashomer, Israel.
   [Pappo, Orit] Hadassah Hebrew Univ, Med Ctr, Dept Pathol, IL-91240 Jerusalem, Israel.
   [Safadi, Rifaat] Hadassah Hebrew Univ, Med Ctr, Liver Unit, IL-91240 Jerusalem, Israel.
   [Schmilovitz-Weiss, Hemda] Hasharon Hosp, Rabin Med Ctr, Gastroenterol Unit, Liver Inst, IL-49372 Petah Tiqwa, Israel.
   [Grozovski, Maria] Ort Braude Coll Engn, Dept Biotechnol, Karmiel, Israel.
C3 Hebrew University of Jerusalem; Hadassah University Medical Center;
   Chaim Sheba Medical Center; Hebrew University of Jerusalem; Hadassah
   University Medical Center; Hebrew University of Jerusalem; Hadassah
   University Medical Center; Rabin Medical Center; Braude Academic College
   of Engineering
RP Ackerman, Z (corresponding author), Hadassah Hebrew Univ, Med Ctr, Dept Med, Mt Scopus Campus,POB 24035, IL-91240 Jerusalem, Israel.
EM zackerman@hadassah.org.il
OI Safadi, Rifaat/0000-0002-8689-5217
CR Ackerman Z, 2005, HYPERTENSION, V45, P1012, DOI 10.1161/01.HYP.0000164570.20420.67
   Ackerman Z, 2008, DIGEST DIS SCI, V53, P777, DOI 10.1007/s10620-007-9911-4
   Aithal GP, 2008, GASTROENTEROLOGY, V135, P1176, DOI 10.1053/j.gastro.2008.06.047
   Akyüz F, 2007, DIGEST DIS SCI, V52, P2359, DOI 10.1007/s10620-006-9145-x
   BAKER H, 1980, NUTR REP INT, V21, P531
   BARNES H, 1973, Journal of Experimental Marine Biology and Ecology, V12, P103, DOI 10.1016/0022-0981(73)90040-3
   BARTLETT GR, 1959, J BIOL CHEM, V234, P469
   Bedoucha M, 2001, J HEPATOL, V35, P17, DOI 10.1016/S0168-8278(01)00066-6
   Belfort R, 2006, NEW ENGL J MED, V355, P2297, DOI 10.1056/NEJMoa060326
   Bonora E, 2000, DIABETES CARE, V23, P57, DOI 10.2337/diacare.23.1.57
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Brunt EM, 1999, AM J GASTROENTEROL, V94, P2467, DOI 10.1111/j.1572-0241.1999.01377.x
   Caldwell SH, 2001, AM J GASTROENTEROL, V96, P519
   Caldwell SH, 2007, HEPATOLOGY, V46, P285, DOI 10.1002/hep.21881
   CARLBERG I, 1985, METHOD ENZYMOL, V113, P484
   Chao L, 2000, J CLIN INVEST, V106, P1221, DOI 10.1172/JCI11245
   Chaudhry J, 2007, LIFE SCI, V80, P1135, DOI 10.1016/j.lfs.2006.12.004
   Chojkier M, 2005, HEPATOLOGY, V41, P237, DOI 10.1002/hep.20567
   Fan JG, 2007, J GASTROEN HEPATOL, V22, P1086, DOI 10.1111/j.1440-1746.2006.04781.x
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   GAN KN, 1991, DRUG METAB DISPOS, V19, P100
   García-Ruiz I, 2007, HEPATOLOGY, V46, P414, DOI 10.1002/hep.21687
   GOTTFRIED SP, 1973, CLIN CHEM, V19, P1077
   Inoue I, 1997, BIOCHEM BIOPH RES CO, V235, P113, DOI 10.1006/bbrc.1997.6512
   Leiter EH, 2006, ENDOCRINOLOGY, V147, P919, DOI 10.1210/en.2005-0839
   Lutchman G, 2007, HEPATOLOGY, V46, P424, DOI 10.1002/hep.21661
   Nan YM, 2009, SCAND J GASTROENTERO, V44, P358, DOI 10.1080/00365520802530861
   Narayanan PK, 2003, CYTOM PART A, V52A, P28, DOI 10.1002/cyto.a.10011
   Neuschwander-Tetri BA, 2003, HEPATOLOGY, V38, P1008, DOI 10.1053/jhep.2003.50420
   Ota T, 2007, GASTROENTEROLOGY, V132, P282, DOI 10.1053/j.gastro.2006.10.014
   Promrat K, 2004, HEPATOLOGY, V39, P188, DOI 10.1002/hep.20012
   Ratziu V, 2008, GASTROENTEROLOGY, V135, P100, DOI 10.1053/j.gastro.2008.03.078
   Ratziu V, 2010, HEPATOLOGY, V51, P445, DOI 10.1002/hep.23270
   REAVEN GM, 1991, AM J MED, V90, pS7, DOI 10.1016/0002-9343(91)90028-V
   Safadi R, 2004, GASTROENTEROLOGY, V127, P870, DOI 10.1053/j.gastro.2004.04.062
   Sanyal AJ, 2004, CLIN GASTROENTEROL H, V2, P1107, DOI 10.1016/S1542-3565(04)00457-4
   Sanyal Arun J, 2002, Gastroenterology, V123, P1705, DOI 10.1053/gast.2002.36572
   SHAN XQ, 1990, PHARMACOL THERAPEUT, V47, P61, DOI 10.1016/0163-7258(90)90045-4
   Stein LL, 2009, ADV THER, V26, P893, DOI 10.1007/s12325-009-0072-z
   Tahan V, 2007, DIGEST DIS SCI, V52, P3465, DOI 10.1007/s10620-007-9756-x
   TAYLOR RP, 1978, J CHEM EDUC, V55, P36
   Tiikkainen M, 2004, DIABETES, V53, P2169, DOI 10.2337/diabetes.53.8.2169
   Vuppalanchi R, 2009, HEPATOLOGY, V49, P306, DOI 10.1002/hep.22603
   Whitehead JP, 2006, DIABETES OBES METAB, V8, P264, DOI 10.1111/j.1463-1326.2005.00510.x
   Xu AM, 2003, J CLIN INVEST, V112, P91, DOI 10.1172/JCI200317797
   YAGI K, 1987, CHEM PHYS LIPIDS, V45, P337, DOI 10.1016/0009-3084(87)90071-5
NR 46
TC 36
Z9 38
U1 0
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-7835
EI 1742-7843
J9 BASIC CLIN PHARMACOL
JI Basic Clin. Pharmacol. Toxicol.
PD AUG
PY 2010
VL 107
IS 2
BP 663
EP 668
DI 10.1111/j.1742-7843.2010.00553.x
PG 6
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA 626BB
UT WOS:000279939600006
PM 20210788
OA Bronze
DA 2025-06-11
ER

PT J
AU Lohr, M
   Folkmann, JK
   Sheykhzade, M
   Jensen, LJ
   Kermanizadeh, A
   Loft, S
   Moller, P
AF Lohr, Mille
   Folkmann, Janne K.
   Sheykhzade, Majid
   Jensen, Lars J.
   Kermanizadeh, Ali
   Loft, Steffen
   Moller, Peter
TI Hepatic Oxidative Stress, Genotoxicity and Vascular Dysfunction in Lean
   or Obese Zucker Rats
SO PLOS ONE
LA English
DT Article
ID FATTY LIVER-DISEASE; DIESEL EXHAUST PARTICLES; DNA-DAMAGE;
   8-OXO-7,8-DIHYDRO-2'-DEOXYGUANOSINE EXCRETION; NONALCOHOLIC
   STEATOHEPATITIS; ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; GLYCEMIC CONTROL; GENE-EXPRESSION
AB Metabolic syndrome is associated with increased risk of cardiovascular disease, which could be related to oxidative stress. Here, we investigated the associations between hepatic oxidative stress and vascular function in pressurized mesenteric arteries from lean and obese Zucker rats at 14, 24 and 37 weeks of age. Obese Zucker rats had more hepatic fat accumulation than their lean counterparts. Nevertheless, the obese rats had unaltered age-related level of hepatic oxidatively damaged DNA in terms of formamidopyrimidine DNA glycosylase (FPG) or human oxoguanine DNA glycosylase (hOGG1) sensitive sites as measured by the comet assay. There were decreasing levels of oxidatively damaged DNA with age in the liver of lean rats, which occurred concurrently with increased expression of Ogg1. The 37 week old lean rats also had higher expression level of Hmox1 and elevated levels of DNA strand breaks in the liver. Still, both strain of rats had increased protein level of HMOX1 in the liver at 37 weeks. The external and lumen diameters of mesenteric arteries increased with age in obese Zucker rats with no change in media cross-sectional area, indicating outward re-modelling without hypertrophy of the vascular wall. There was increased maximal response to acetylcholine-mediated endothelium-dependent vasodilatation in both strains of rats. Collectively, the results indicate that obese Zucker rats only displayed a modest mesenteric vascular dysfunction, with no increase in hepatic oxidative stress-generated DNA damage despite substantial hepatic steatosis.
C1 [Lohr, Mille; Folkmann, Janne K.; Kermanizadeh, Ali; Loft, Steffen; Moller, Peter] Univ Copenhagen, Environm Hlth Sect, Dept Publ Hlth, DK-1014 Copenhagen K, Denmark.
   [Sheykhzade, Majid] Univ Copenhagen, Fac Hlth & Med Sci, Dept Drug Design & Pharmacol, DK-2100 Copenhagen O, Denmark.
   [Jensen, Lars J.] Fac Hlth & Med Sci, Dept Vet Clin & Anim Sci, DK-1870 Frederiksberg C, Denmark.
C3 University of Copenhagen; University of Copenhagen
RP Moller, P (corresponding author), Univ Copenhagen, Environm Hlth Sect, Dept Publ Hlth, Oster Farimagsgade 5A, DK-1014 Copenhagen K, Denmark.
EM pemo@sund.ku.dk
RI Jensen, Lars/A-9340-2008; Kermanizadeh, Ali/AAD-6281-2019; Kermanizadeh,
   Ali/L-9691-2017
OI Jensen, Lars Jorn/0000-0003-4559-7456; Kermanizadeh,
   Ali/0000-0002-2989-9078; Sheykhzade, Majid/0000-0002-4561-0326; Loft,
   Steffen/0000-0001-9552-8518
FU Danish Research Councils
FX Funding provided by Danish Research Councils. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
CR de Artiñano AA, 2009, BRIT J NUTR, V102, P1246, DOI 10.1017/S0007114509990729
   Barregard L, 2013, ANTIOXID REDOX SIGN, V18, P2377, DOI 10.1089/ars.2012.4714
   Bhatia LS, 2012, EUR HEART J, V33, P1190, DOI 10.1093/eurheartj/ehr453
   Bouvet C, 2007, HYPERTENSION, V50, P248, DOI 10.1161/HYPERTENSIONAHA.107.088716
   Carmiel-Haggai M, 2004, FASEB J, V18, P136, DOI 10.1096/fj.04-2291fje
   Collins AR, 2012, ARTERIOSCL THROM VAS, V32, P2839, DOI 10.1161/ATVBAHA.112.300345
   Danielsen PH, 2010, TOXICOL SCI, V118, P574, DOI 10.1093/toxsci/kfq290
   Dybdahl M, 2003, CARCINOGENESIS, V24, P1759, DOI 10.1093/carcin/bgg147
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Ersson C, 2013, MUTAGENESIS, V28, P279, DOI 10.1093/mutage/get001
   Folkmann JK, 2007, MUTAGENESIS, V22, P105, DOI 10.1093/mutage/gel059
   Folkmann JK, 2012, TOXICOL SCI, V129, P98, DOI 10.1093/toxsci/kfs180
   Forchhammer L, 2012, MUTAGENESIS, V27, P665, DOI 10.1093/mutage/ges032
   Forchhammer L, 2010, MUTAGENESIS, V25, P113, DOI 10.1093/mutage/gep048
   Francque S, 2012, LAB INVEST, V92, P1428, DOI 10.1038/labinvest.2012.103
   Gozzelino R, 2010, ANNU REV PHARMACOL, V50, P323, DOI 10.1146/annurev.pharmtox.010909.105600
   Gupte AA, 2010, HEPATOLOGY, V52, P2001, DOI 10.1002/hep.23941
   Gupte RS, 2009, FREE RADICAL BIO MED, V47, P219, DOI 10.1016/j.freeradbiomed.2009.01.028
   Imrie H, 2010, BBA-MOL CELL BIOL L, V1801, P320, DOI 10.1016/j.bbalip.2009.09.025
   Johansson C, 2010, MUTAGENESIS, V25, P125, DOI 10.1093/mutage/gep055
   Kitade M, 2006, HEPATOLOGY, V44, P983, DOI 10.1002/hep.21338
   Laurant P, 2004, CAN J PHYSIOL PHARM, V82, P269, DOI 10.1139/Y04-026
   Loft S, 2006, CARCINOGENESIS, V27, P1245, DOI 10.1093/carcin/bgi313
   Loft S, 2013, CANCER EPIDEM BIOMAR, V22, P1289, DOI 10.1158/1055-9965.EPI-13-0229
   Loft S, 2012, FREE RADICAL BIO MED, V52, P167, DOI 10.1016/j.freeradbiomed.2011.10.439
   Ma Q, 2013, ANNU REV PHARMACOL, V53, P401, DOI 10.1146/annurev-pharmtox-011112-140320
   Mendez-González J, 2011, BBA-MOL CELL BIOL L, V1811, P1186, DOI 10.1016/j.bbalip.2011.07.019
   Mikkelsen L, 2009, FREE RADICAL BIO MED, V47, P608, DOI 10.1016/j.freeradbiomed.2009.05.030
   Mingorance C, 2009, BRIT J NUTR, V102, P1145, DOI 10.1017/S0007114509389230
   Moller P, 2010, FREE RADICAL BIO MED, V48, P1275, DOI 10.1016/j.freeradbiomed.2010.02.003
   Mozaffari MS, 2009, NUTR METAB, V6, DOI 10.1186/1743-7075-6-51
   Okada K, 2013, J GASTROENTEROL, V48, P620, DOI 10.1007/s00535-012-0659-z
   Oltman CL, 2006, AM J PHYSIOL-HEART C, V291, pH1780, DOI 10.1152/ajpheart.01297.2005
   Panchal SK, 2012, J NUTR, V142, P1026, DOI 10.3945/jn.111.157263
   Risom L, 2003, ARCH TOXICOL, V77, P651, DOI 10.1007/s00204-003-0502-7
   Risom L, 2003, CARCINOGENESIS, V24, P1847, DOI 10.1093/carcin/bgg144
   Risom L, 2003, FREE RADICAL RES, V37, P957, DOI 10.1080/1071576031000150788
   Risom L, 2007, FREE RADICAL RES, V41, P172, DOI 10.1080/10715760601024122
   Rolo AP, 2012, FREE RADICAL BIO MED, V52, P59, DOI 10.1016/j.freeradbiomed.2011.10.003
   Romanko OP, 2005, AM J PHYSIOL-HEART C, V289, pH2097, DOI 10.1152/ajpheart.00213.2005
   Salcedo A, 2007, HEPATOL RES, V37, P811, DOI 10.1111/j.1872-034X.2007.00135.x
   Shin S, 2009, EUR J PHARMACOL, V620, P138, DOI 10.1016/j.ejphar.2009.08.022
   Stoll P, 2011, WORLD J GASTROENTERO, V17, P4184, DOI 10.3748/wjg.v17.i37.4184
   Su K, 2012, J BIOL CHEM, V287, P28564, DOI 10.1074/jbc.M112.360081
   Subramanian R, 2003, EUR J PHARMACOL, V477, P143, DOI 10.1016/j.ejphar.2003.08.003
   Tenorio NM, 2013, CLINICS, V68, P385, DOI 10.6061/clinics/2013(03)OA16
   Vesterdal LK, 2014, TOXICOL APPL PHARM, V274, P350, DOI 10.1016/j.taap.2013.10.001
   Ward MR, 2000, CIRCULATION, V102, P1186, DOI 10.1161/01.CIR.102.10.1186
   Winczura A, 2012, FREE RADICAL RES, V46, P442, DOI 10.3109/10715762.2012.658516
   Xu JL, 2012, DIABETES, V61, P3208, DOI 10.2337/db11-1716
   Young EJ, 2008, DIABETOLOGIA, V51, P872, DOI 10.1007/s00125-008-0934-y
   Zhang YKJ, 2012, TOXICOL APPL PHARM, V264, P305, DOI 10.1016/j.taap.2012.09.014
   Zhao L, 2011, J GASTROEN HEPATOL, V26, P875, DOI 10.1111/j.1440-1746.2010.06560.x
NR 53
TC 10
Z9 11
U1 0
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 4
PY 2015
VL 10
IS 3
AR e0118773
DI 10.1371/journal.pone.0118773
PG 19
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CC9JM
UT WOS:000350685900068
PM 25738756
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Ion, RM
   Sibianu, M
   Neagoe, R
   Sala, D
   Beresescu, F
   Daniealopol, V
   Daniealopol, R
   Muresan, M
AF Ion, Razvan Marius
   Sibianu, Melania
   Neagoe, Radu
   Sala, Daniela
   Beresescu, Felicia
   Daniealopol, Valentin
   Daniealopol, Ruxandra
   Muresan, Mircea
TI The role of nitro oxidative factors in metabolic dysfunctions: A link
   between severe obesity and weight-loss treatment - a narrative review
SO REVISTA ROMANA DE MEDICINA DE LABORATOR
LA English
DT Review
DE bariatric surgery; oxidative stress; inflammation biomarkers; severe
   obesity
AB Introduction: Metabolic syndrome (MS) is linked to oxidative stress and intracellular redox imbalance, both triggered by chronic inflammatory conditions. The aim of our research was to figure out if bariatric surgery changes the production of free radicals in obese people. In addition, the relationship between metabolic syndrome(MS) and associated conditions is represented by oxidative stress (OS) and intracellular redox imbalance, both of which are induced by the chronic inflammatory conditions that define MS. Methods: The literature search was conducted on PubMed, Cochrane Library, and ScienceDirect, using terms related to severe obesity, nitro-oxidative factors, pro-inflammatory status and reactive oxygen species. Six studies were included. We included papers published till 2022, with a concentration on more recent publications (January 2019 to December 2022). Results: Studies that analyzed the status of the patient after bariatric surgery at 1, 2, 3, 6, 12 months were included in the review, regarding inflammation: CRP levels,IL-6, and regarding oxidative stress: MPO serum activity, blood plasma proteins: dityrosine, kynurenine, glycophore, amyloid and Amadori products, had been found strongly statistically significant decreased at each periodic analyze, the same thing applied to regulatory hormones such as leptin, and due to the fact that these patients have the possibility to keep their weight stable for a longer period, all these factors kept their levels low even 4 years after the intervention. Conclusion: Bariatric surgery is an efficient and quick solution in increasing the quality of life.
C1 [Ion, Razvan Marius; Daniealopol, Ruxandra] George Emil Palade Univ Med Pharm Sci & Technol Ta, Mures Cty Emergency Hosp, Doctoral Sch Med, Dept Surg 2, Targu Mures, Romania.
   [Sibianu, Melania] George Emil Palade Univ Med Pharm Sci & Technol Ta, Fac Pharm, Internal Med, Targu Mures, Romania.
   [Neagoe, Radu; Sala, Daniela; Daniealopol, Valentin] George Emil Palade Univ Med Pharm Sci & Technol Ta, Mures Cty Emergency Hosp, Fac Med, Dept Surg 2, Targu Mures, Romania.
   [Beresescu, Felicia] George Emil Palade Univ Med Pharm Sci & Technol Ta, Fac Dent, Dept Morphol Teeth & Dent Arches, Targu Mures, Romania.
   [Muresan, Mircea] George Emil Palade Univ Med Pharm Sci & Technol Ta, Fac Med English, Anat Dept, Targu Mures, Romania.
RP Sibianu, M (corresponding author), George Emil Palade Univ Med Pharm Sci & Technol Ta, Fac Pharm, Internal Med, Targu Mures, Romania.
EM melaniasibianu@gmail.com
RI Ion, Razvan Marius/IAM-3721-2023; Sala, Daniela Tatiana/IAM-2498-2023;
   Muresan, Mircea/LXV-0408-2024; Beresescu, Felicia/MCY-6709-2025; N,
   Radu/AAE-6364-2022; Daniealopol, Ruxandra/NGS-5901-2025; Daniealopol,
   Valentin/JVZ-1974-2024
OI Daniealopol, Valentin/0009-0003-4675-107X; Muresan,
   Mircea/0000-0002-5262-8524
FU George Emil Palade University of Medicine, Pharmacy, Science, and
   Technology of Targu Mures, Romania [294/4/14.01.2020]
FX This work was supported by the George Emil Palade University of
   Medicine, Pharmacy, Science, and Technology of Targu Mures, Romania,
   Research Grant Number 294/4/14.01.2020.
CR Abad-Jiménez Z, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9080734
   [Anonymous], 2020, Eur Heart J, V41, P111, DOI [10.1093/eurheartj/ehz45510, DOI 10.1093/EURHEARTJ/EHZ45510]
   [Anonymous], 2021, INTRO REACTIVE OXYGE
   [Anonymous], 2022, WHO EUROPEAN REGIONAL OBESITY REPORT 2022 (No. 9789289057738)
   Barati E, 2019, BIOCHEM GENET, V57, P695, DOI 10.1007/s10528-019-09913-5
   Catoi AF, 2018, NUTRIENTS, V10, DOI 10.3390/nu10091199
   Catoi AF, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/1583212
   Choromanska B, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9111087
   Choromanska B, 2020, J CLIN MED, V9, DOI 10.3390/jcm9040976
   Ciobarca Daniela Muresan, 2022, Med Pharm Rep, V95, P24, DOI 10.15386/mpr-2094
   Di Lorenzo N, 2020, SURG ENDOSC, V34, P2332, DOI 10.1007/s00464-020-07555-y
   Ghesmaty Sangachin Mahboobeh, 2018, BMC Obes, V5, P28, DOI 10.1186/s40608-018-0205-5
   Gonzalez-Ponce F, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0255854
   Almasi MH, 2023, WORLD J SURG, V47, P209, DOI 10.1007/s00268-022-06769-6
   Horn RC, 2017, REV ASSOC MED BRAS, V63, P229, DOI 10.1590/1806-9282.63.03.229
   Mach F, ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk
   Metere A, 2020, BIOMEDICINES, V8, DOI 10.3390/biomedicines8060168
   Min T, 2020, OBES SURG, V30, P1712, DOI 10.1007/s11695-019-04377-3
   Rodríguez-Rodríguez E, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030855
   Sies H, 2020, NAT REV MOL CELL BIO, V21, P363, DOI 10.1038/s41580-020-0230-3
   Soldo AM, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11081537
   Tozzo C, 2020, OBES SURG, V30, P3301, DOI 10.1007/s11695-020-04561-w
   Triposkiadis F, 2022, HEART FAIL REV, V27, P407, DOI 10.1007/s10741-021-10103-y
   Zhou X, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.119.012091
NR 24
TC 0
Z9 0
U1 1
U2 1
PU SCIENDO
PI WARSAW
PA BOGUMILA ZUGA 32A, WARSAW, MAZOVIA, POLAND
SN 1841-6624
EI 2284-5623
J9 REV ROMANA MED LAB
JI Rev. Romana Med. Lab.
PD APR 1
PY 2024
VL 32
IS 2
BP 135
EP 142
DI 10.2478/rrlm-2024-0012
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA TG9D4
UT WOS:001240221800002
OA gold
DA 2025-06-11
ER

PT J
AU Zhou, X
   Kang, C
   Hu, YH
   Wang, XC
AF Zhou, Xue
   Kang, Chen
   Hu, YuHong
   Wang, XingChen
TI Study on insulin resistance and ischemic cerebrovascular disease: A
   bibliometric analysis via CiteSpace
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Review
DE insulin resistance; ischemic cerebrovascular disease; association;
   oxidative stress; inflammation; CiteSpace
ID TRIGLYCERIDE-GLUCOSE INDEX; INDEPENDENT RISK-FACTOR; NONDIABETIC
   PATIENTS; METABOLIC SYNDROME; SECONDARY PREVENTION; STROKE; SENSITIVITY;
   PIOGLITAZONE; EVENTS; ATTACK
AB BackgroundIt is reported that insulin resistance widely exists in non-diabetic patients with a recent history of transient ischemic attack (TIA) or ischemic stroke. There is currently strong evidence to prove the bidirectional effect of glucose metabolism disorders and stroke events. Therefore, it is necessary to retrospectively tease out the current status, hotspots, and frontiers of insulin resistance and ischemic cerebrovascular disease through CiteSpace. Materials and methodsWe searched the Web of Science (WOS) for studies related to insulin resistance and ischemic cerebrovascular disease from 1999 to April 2022, then downloaded the data into CiteSpace to generate a knowledge visualization map. ResultsA total of 1,500 publications relevant to insulin resistance and ischemic cerebrovascular disease were retrieved. The USA had the most articles on this topic, followed by PEOPLES R CHINA and JAPAN. WALTER N KERNAN was the most prolific author, whose research mainly focused on insulin resistance intervention after stroke (IRIS) trial. The most common keywords were myocardial ischemia, metabolic syndrome, ischemic stroke, cerebral ischemia, association, oxidative stress, inflammation, and adipose tissue. Major ongoing research trends include three aspects: (1) the association between insulin resistance and ischemic cerebrovascular disease in non-diabetic patients, (2) the intrinsic pathological mechanism between insulin resistance and ischemic cerebrovascular disease, and (3) early intervention of insulin resistance to improve the prognosis of stroke. ConclusionThe results of this bibliometric study provide the current status and trends of clinical research publications in the field of insulin resistance and ischemic cerebrovascular disease. Insulin resistance is strongly associated with the occurrence of ischemic stroke, early neurological deterioration in stroke patients, post-stroke depression, and cerebral small vessel disease. Early treatment of insulin resistance can be an effective way to prevent the onset of ischemic stroke and improve stroke prognosis. This study may help researchers to identify hot topics and explore new research directions.
C1 [Zhou, Xue] Shandong Univ Tradit Chinese Med, Clin Med Coll 1, Jinan, Peoples R China.
   [Kang, Chen] Shandong Univ Tradit Chinese Med, Div Neurol, Affiliated Hosp, Jinan, Peoples R China.
   [Hu, YuHong] 960th Hosp PLA Joint Logist Support Force, Div Cardiol, Jinan, Peoples R China.
   [Wang, XingChen] Shandong Univ Tradit Chinese Med, Dept Neurol, Affiliated Hosp 2, Jinan, Peoples R China.
   [Wang, XingChen] Shandong Univ Tradit Chinese Med, Clin Med Coll 2, Jinan, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Shandong University
   of Traditional Chinese Medicine; Shandong University of Traditional
   Chinese Medicine; Shandong University of Traditional Chinese Medicine
RP Wang, XC (corresponding author), Shandong Univ Tradit Chinese Med, Dept Neurol, Affiliated Hosp 2, Jinan, Peoples R China.; Wang, XC (corresponding author), Shandong Univ Tradit Chinese Med, Clin Med Coll 2, Jinan, Peoples R China.
EM sdlcwxc@163.com
FU Natural Science Foundation of Shandong Province [ZR2020MH156]; National
   Famous Old Chinese Medicine Experts Inheritance Studio Construction
   Project; National Chinese Medicine Human Education Letter [2022] [75]
FX Funding This study was supported by the Natural Science Foundation of
   Shandong Province (Grant Number: ZR2020MH156) and the National Famous
   Old Chinese Medicine Experts Inheritance Studio Construction Project
   (Grant Number: National Chinese Medicine Human Education Letter [2022]
   No. 75).
CR Ago T, 2018, NEUROLOGY, V90, pE1470, DOI 10.1212/WNL.0000000000005358
   Baydar O, 2021, ANGIOLOGY, V72, P994, DOI 10.1177/00033197211007719
   Beale EG, 2013, J INVEST MED, V61, P11, DOI 10.2310/JIM.0b013e3182746f95
   Boden G, 2011, CURR OPIN ENDOCRINOL, V18, P139, DOI 10.1097/MED.0b013e3283444b09
   Boden-Albala B, 2008, STROKE, V39, P30, DOI 10.1161/STROKEAHA.107.496588
   Bonora E, 2003, DIABETES CARE, V26, P1251, DOI 10.2337/diacare.26.4.1251
   Bravata DM, 2005, NEUROEPIDEMIOLOGY, V25, P69, DOI 10.1159/000086286
   Bruce KD, 2010, J NUTR, V140, P648, DOI 10.3945/jn.109.111179
   Campbell BCV, 2020, LANCET, V396, P129, DOI 10.1016/S0140-6736(20)31179-X
   Chen CM, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0223994
   Chen CM, 2014, EXPERT OPIN BIOL TH, V14, P1295, DOI 10.1517/14712598.2014.920813
   Chen CM, 2004, P NATL ACAD SCI USA, V101, P5303, DOI 10.1073/pnas.0307513100
   Chen WQ, 2020, BMJ OPEN DIAB RES CA, V8, DOI 10.1136/bmjdrc-2020-001217
   Chu LM, 2017, ATHEROSCLEROSIS, V265, P87, DOI 10.1016/j.atherosclerosis.2017.08.017
   Despres JP, 1996, NEW ENGL J MED, V334, P952, DOI 10.1056/NEJM199604113341504
   Domingues N, 2021, REV PORT CARDIOL, V40, P545, DOI 10.1016/j.repc.2021.06.004
   Dormandy JA, 2005, LANCET, V366, P1279, DOI 10.1016/S0140-6736(05)67528-9
   Falagas ME, 2008, FASEB J, V22, P338, DOI 10.1096/fj.07-9492LSF
   Fann DYW, 2018, MOL NEUROBIOL, V55, P1082, DOI 10.1007/s12035-017-0394-9
   Feigin VL, 2018, NEW ENGL J MED, V379, P2429, DOI 10.1056/NEJMoa1804492
   Feng X, 2022, HORM METAB RES, V54, P175, DOI 10.1055/a-1766-0202
   García-Culebras A, 2019, STROKE, V50, P2922, DOI 10.1161/STROKEAHA.119.025085
   Gaspar RS, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/2423547
   Harada S, 2009, BRAIN RES, V1279, P174, DOI 10.1016/j.brainres.2009.05.014
   Hong P, 2019, J NEUROINFLAMM, V16, DOI 10.1186/s12974-019-1498-0
   Hu LL, 2022, INT J GEN MED, V15, P1271, DOI 10.2147/IJGM.S350474
   Ikmal SIQS, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/698567
   Jing J, 2017, STROKE, V48, P887, DOI 10.1161/STROKEAHA.116.015613
   Katsumata T, 2010, NEUROL RES, V32, P743, DOI 10.1179/016164109X12608733393755
   Kawano T, 2001, J CEREBR BLOOD F MET, V21, P1268, DOI 10.1097/00004647-200111000-00003
   Kelley N, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20133328
   Kernan WN, 2016, NEW ENGL J MED, V374, P1321, DOI 10.1056/NEJMoa1506930
   Kernan WN, 2005, ARCH INTERN MED, V165, P227, DOI 10.1001/archinte.165.2.227
   Kernan WN, 2003, STROKE, V34, P1431, DOI 10.1161/01.STR.0000071108.00234.0E
   Kernan WN, 2003, NEUROLOGY, V60, P1447, DOI 10.1212/01.WNL.0000063318.66140.A3
   Kernan WN, 2002, NEUROLOGY, V59, P809, DOI 10.1212/WNL.59.6.809
   Kim B, 2011, ANTIOXID REDOX SIGN, V14, P1829, DOI 10.1089/ars.2010.3816
   Kleindorfer DO, 2021, STROKE, V52, pE364, DOI 10.1161/STR.0000000000000375
   Kullmann S, 2022, DIABETES CARE, V45, P398, DOI 10.2337/dc21-1136
   Kullmann S, 2016, PHYSIOL REV, V96, P1169, DOI 10.1152/physrev.00032.2015
   Lebovitz HE, 2001, EXP CLIN ENDOCR DIAB, V109, pS135, DOI 10.1055/s-2001-18576
   Lee JE, 2016, STROKE, V47, P2938, DOI 10.1161/STROKEAHA.116.014097
   Luo HF, 2021, FRONT PSYCHOL, V12, DOI 10.3389/fpsyg.2021.759347
   Mi DH, 2020, NEUROL SCI, V41, P1467, DOI 10.1007/s10072-019-04221-7
   Miao MY, 2022, CARDIOVASC DIABETOL, V21, DOI 10.1186/s12933-022-01472-1
   Nissen SE, 2007, NEW ENGL J MED, V356, P2457, DOI 10.1056/NEJMoa072761
   Novo S, 2012, ATHEROSCLEROSIS, V223, P468, DOI 10.1016/j.atherosclerosis.2012.05.018
   O'Donnell MJ, 2010, LANCET, V376, P112, DOI 10.1016/S0140-6736(10)60834-3
   Pawlos A, 2021, MOLECULES, V26, DOI 10.3390/molecules26237213
   Qiu HC, 2018, J AFFECT DISORDERS, V231, P1, DOI 10.1016/j.jad.2018.01.023
   Rundek T, 2010, ARCH NEUROL-CHICAGO, V67, P1195, DOI 10.1001/archneurol.2010.235
   Seoane PI, 2020, J CELL BIOL, V219, DOI 10.1083/jcb.202006194
   Shi WR, 2020, NUTR METAB CARDIOVAS, V30, P245, DOI 10.1016/j.numecd.2019.09.015
   Someya Y, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-00377-5
   St-Pierre AC, 2005, CAN MED ASSOC J, V172, P1301, DOI 10.1503/cmaj.1040834
   Synnestvedt Marie B, 2005, AMIA Annu Symp Proc, P724
   Synnestvedt Marie B, 2005, AMIA Annu Symp Proc, P1129
   Virani SS, 2020, CIRCULATION, V141, pE139, DOI 10.1161/CIR.0000000000000757
   Viscoli CM, 2019, STROKE, V50, P95, DOI 10.1161/STROKEAHA.118.022745
   Viscoli CM, 2014, AM HEART J, V168, P823, DOI 10.1016/j.ahj.2014.07.016
   Wang YY, 2011, AM J PHYSIOL-ENDOC M, V300, pE155, DOI 10.1152/ajpendo.00301.2010
   Wang YJ, 2020, STROKE VASC NEUROL, V5, P211, DOI 10.1136/svn-2020-000457
   Xiao MJ, 2018, INT J GERIATR PSYCH, V33, P956, DOI 10.1002/gps.4878
   Xu J, 2016, J STROKE CEREBROVASC, V25, P1705, DOI 10.1016/j.jstrokecerebrovasdis.2016.03.043
   Yang XL, 2019, FRONT AGING NEUROSCI, V11, DOI 10.3389/fnagi.2019.00127
   Yang YT, 2020, SCHIZOPHR RES, V223, P366, DOI 10.1016/j.schres.2020.07.005
   Zhang BJ, 2020, FRONT MED-LAUSANNE, V7, DOI 10.3389/fmed.2020.591036
   Zhao H, 2006, MOL NEUROBIOL, V34, P249, DOI 10.1385/MN:34:3:249
   Zhong DL, 2020, FRONT NEUROL, V11, DOI 10.3389/fneur.2020.00984
   Zhou Q, 2021, FRONT PEDIATR, V9, DOI 10.3389/fped.2021.705033
   Zhou YM, 2020, FRONT NEUROL, V11, DOI 10.3389/fneur.2020.00456
NR 71
TC 22
Z9 22
U1 14
U2 99
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD MAR 6
PY 2023
VL 11
AR 1021378
DI 10.3389/fpubh.2023.1021378
PG 14
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 9Y8KX
UT WOS:000950704800001
PM 36950100
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Haeiwa, H
   Fujita, T
   Saitoh, Y
   Miwa, N
AF Haeiwa, Haruna
   Fujita, Takashi
   Saitoh, Yasukazu
   Miwa, Nobuhiko
TI Oleic acid promotes adaptability against oxidative stress in 3T3-L1
   cells through lipohormesis
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Oleic acid; Fatty acid quantity; Fatty acid quality; Lipid peroxidation;
   Cell injury; Lipohormesis
ID POLYUNSATURATED FATTY-ACIDS; LIPID-PEROXIDATION; INSULIN-RESISTANCE;
   ADAPTIVE RESPONSE; METABOLIC SYNDROME; INDUCED APOPTOSIS; UP-REGULATION;
   DAMAGE; HYDROPEROXIDE; OBESITY
AB Although fatty acids are important components of biological membranes, energy sources, and signal transducers or precursors of lipid mediators, excess intake of fatty acids and their accumulation cause obesity and metabolic syndrome. Thus, fatty acid quantity is known to be an important factor for obesity-related diseases, but the effects of different types of fatty acids (i.e., fatty acid quality) on human health are not completely understood. We here focused on the relationship between fatty acid quality and oxidative stress by investigating whether resistibility to tert-butyl hydrperoxide (t-BuOOH)-induced oxidative stress in 3T3-L1 cells varied according to the fatty acid type. Among eight fatty acids (both saturated and unsaturated) tested, oleic acid (OA) exerted the most pronounced cytoprotective effects, with efficacy over a wide range of concentrations. OA treatment markedly enhanced the intracellular levels of lipid peroxidation markers, including N-epsilon-(hexanoyl) lysine, 4-hydroxy-2-nonenal, and acrolein. The levels of these markers in OA-treated cells were decreased after t-BuOOH exposure, whereas the levels in untreated control cells were notably increased after t-BuOOH exposure. Our results suggested that unsaturated fatty acids, particularly OA, could promote an adaptive response and enhance cell tolerance through increased cellular antioxidative capacity via OA-induced mild lipid peroxidation (lipohormesis), and thus protect cells against subsequent oxidative stress-related injury.
C1 [Haeiwa, Haruna; Fujita, Takashi; Saitoh, Yasukazu] Prefectural Univ Hiroshima, Lab Biosci & Biotechnol Cell Funct Control, Fac Life & Environm Sci, Shobara, Hiroshima 7270023, Japan.
   [Miwa, Nobuhiko] Butsuryo Coll Osaka, Fac Hlth Sci, Sakai, Osaka 5938324, Japan.
RP Saitoh, Y (corresponding author), Prefectural Univ Hiroshima, Lab Biosci & Biotechnol Cell Funct Control, Fac Life & Environm Sci, 562 Nanatsuka, Shobara, Hiroshima 7270023, Japan.
EM ysaito@pu-hiroshima.ac.jp
RI saitoh, yasukazu/AAQ-6432-2021
OI Saitoh, Yasukazu/0000-0002-6288-7634
CR Borradaile NM, 2006, MOL BIOL CELL, V17, P770, DOI 10.1091/mbc.E05-08-0742
   Brookheart RT, 2009, CELL METAB, V10, P9, DOI 10.1016/j.cmet.2009.03.011
   Cai JY, 2000, PROG RETIN EYE RES, V19, P205, DOI 10.1016/S1350-9462(99)00009-9
   Calder PC, 2008, MOL NUTR FOOD RES, V52, P885, DOI 10.1002/mnfr.200700289
   Calder PC, 2010, NUTRIENTS, V2, P355, DOI 10.3390/nu2030355
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Chen ZH, 2006, FEBS LETT, V580, P479, DOI 10.1016/j.febslet.2005.12.045
   Chen ZH, 2005, J BIOL CHEM, V280, P41921, DOI 10.1074/jbc.M508556200
   Chen ZH, 2006, J BIOL CHEM, V281, P14440, DOI 10.1074/jbc.M600260200
   COMPORTI M, 1987, CHEM PHYS LIPIDS, V45, P143, DOI 10.1016/0009-3084(87)90064-8
   De Lorgeril Michel, 2007, Subcell Biochem, V42, P283
   Eguchi K, 2012, CELL METAB, V15, P518, DOI 10.1016/j.cmet.2012.01.023
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   HALLIWELL B, 1984, BIOCHEM J, V219, P1, DOI 10.1042/bj2190001
   Holzer RG, 2011, CELL, V147, P173, DOI 10.1016/j.cell.2011.08.034
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   Hotamisligil GS, 2008, NAT REV IMMUNOL, V8, P923, DOI 10.1038/nri2449
   KANEKO T, 1987, CHEM-BIOL INTERACT, V63, P127, DOI 10.1016/0009-2797(87)90093-7
   Kato S, 2010, J BIOMED NANOTECHNOL, V6, P52, DOI 10.1166/jbn.2010.1091
   Kawai Y, 2006, J LIPID RES, V47, P1386, DOI 10.1194/jlr.M600091-JLR200
   Kinter M, 1996, J NUTR, V126, P2952, DOI 10.1093/jn/126.12.2952
   Kopelman PG, 2000, NATURE, V404, P635, DOI 10.1038/35007508
   Kris-Etherton PM, 2002, CIRCULATION, V106, P2747, DOI 10.1161/01.CIR.0000038493.65177.94
   Kusminski CM, 2009, APOPTOSIS, V14, P1484, DOI 10.1007/s10495-009-0352-8
   Listenberger LL, 2001, J BIOL CHEM, V276, P14890, DOI 10.1074/jbc.M010286200
   Liu XB, 2008, J CLIN BIOCHEM NUTR, V43, P26, DOI 10.3164/jcbn.2008040
   Mahipal SVK, 2007, BIOCHEM PHARMACOL, V74, P202, DOI 10.1016/j.bcp.2007.04.005
   Merwald H, 2005, J PHOTOCH PHOTOBIO B, V79, P197, DOI 10.1016/j.jphotobiol.2005.01.002
   MOORE GA, 1983, FEBS LETT, V153, P289, DOI 10.1016/0014-5793(83)80626-7
   Nelson KC, 2002, INVEST OPHTH VIS SCI, V43, P3550
   Ohnishi K, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0058641
   Ohnishi K, 2013, BIOCHEM BIOPH RES CO, V430, P616, DOI 10.1016/j.bbrc.2012.11.104
   Pérez-Martínez P, 2011, CURR PHARM DESIGN, V17, P769, DOI 10.2174/138161211795428948
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Saitoh Y, 2004, J CELL BIOCHEM, V93, P653, DOI 10.1002/jcb.20245
   Saitoh Y, 2003, J CELL BIOCHEM, V89, P321, DOI 10.1002/jcb.10506
   Saitoh Y, 2012, MOL CELL BIOCHEM, V366, P191, DOI 10.1007/s11010-012-1297-8
   Saitoh Y, 2013, MOL CELL BIOCHEM, V380, P129, DOI 10.1007/s11010-013-1666-y
   Saitoh Y, 2010, FREE RADICAL RES, V44, P1072, DOI 10.3109/10715762.2010.499905
   Sales-Campos H, 2013, MINI-REV MED CHEM, V13, P201
   SANDSTROM PA, 1995, FEBS LETT, V365, P66, DOI 10.1016/0014-5793(95)00443-D
   Schrenzel J, 1998, NATURE, V392, P734, DOI 10.1038/33725
   Shibata T, 2006, J BIOL CHEM, V281, P1196, DOI 10.1074/jbc.M509065200
   Shimizu I, 2012, CELL METAB, V15, P51, DOI 10.1016/j.cmet.2011.12.006
   Surh YJ, 2009, ARCH PHARM RES, V32, P1163, DOI 10.1007/s12272-009-1807-8
   Urakawa H, 2003, J CLIN ENDOCR METAB, V88, P4673, DOI 10.1210/jc.2003-030202
   Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
   Ziboh VA, 2000, AM J CLIN NUTR, V71, p361S, DOI 10.1093/ajcn/71.1.361s
NR 49
TC 32
Z9 34
U1 0
U2 8
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD JAN
PY 2014
VL 386
IS 1-2
BP 73
EP 83
DI 10.1007/s11010-013-1846-9
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA AA1AL
UT WOS:000330828400007
PM 24234346
DA 2025-06-11
ER

PT J
AU Lovrencic, MV
   Pibernik-Okanovic, M
   Sekerija, M
   Prasek, M
   Ajdukovic, D
   Kos, J
   Hermanns, N
AF Lovrencic, Marijana Vucic
   Pibernik-Okanovic, Mirjana
   Sekerija, Mario
   Prasek, Manja
   Ajdukovic, Dea
   Kos, Jadranka
   Hermanns, Norbert
TI Improvement in Depressive Symptoms Is Associated with Reduced Oxidative
   Damage and Inflammatory Response in Type 2 Diabetic Patients with
   Subsyndromal Depression: The Results of a Randomized Controlled Trial
   Comparing Psychoeducation, Physical Exercise, and Enhanced Treatment as
   Usual
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID COGNITIVE-BEHAVIORAL THERAPY; SERUM URIC-ACID; METABOLIC SYNDROME;
   SIALIC-ACID; GLYCEMIC CONTROL; STRESS; HEALTH; PEOPLE; INSIGHTS;
   OUTCOMES
AB Aims. To examine one-year changes in oxidative damage and inflammation level in type 2 diabetic patients undergoing behavioral treatment for subsyndromal depression. Materials and Methods. A randomized controlled comparison of psychoeducation (A), physical exercise (B), and enhanced treatment as usual (C) was performed in 209 eligible subjects in a tertiary diabetes care setting. Depressive symptoms (primary outcome) and selected biomarkers of oxidative damage and inflammation (secondary outcomes) were assessed at baseline and six-and twelve-month follow-up. Results. Out of the 74, 67, and 68 patients randomised into groups A, B, and C, respectively, 201 completed the interventions, and 179 were analysed. Participants in all three groups equally improved in depressive symptoms from baseline to one-year follow-up (repeated measures ANOVA; F = 12.51, P < 0.0001, eta(2) = 0.07). Urinary 8-oxo-deoxyguanosine (u-8-oxodG) decreased (F = 10.66, p < 0.0001, eta(2) = 0.06), as did sialic acid and leukocytes (F = 84.57, eta(2) = 0.32 and F = 12.61, eta(2) = 0.07, resp.; p < 0.0001), while uric acid increased (F = 12.53, p < 0.0001, eta(2) = 0.07) in all subjects during one year. Improvement of depressive symptoms at 6 months significantly predicted one-year reduction in u-8-oxodG (beta = 0.15, p = 0.044). Conclusion. Simple behavioral interventions are capable not only of alleviating depressive symptoms, but also of reducing the intensity of damaging oxidative/inflammatory processes in type 2 diabetic patients with subsyndromal depression. This trial is registered with ISRCTN05673017.
C1 [Lovrencic, Marijana Vucic] Merkur Univ Hosp, Dept Lab Med, Zagreb 10000, Croatia.
   [Pibernik-Okanovic, Mirjana; Prasek, Manja; Ajdukovic, Dea; Kos, Jadranka] Merkur Univ Hosp, Vuk Vrhovac Univ Clin Diabet, Zagreb 10000, Croatia.
   [Sekerija, Mario] Croatian Inst Publ Hlth, Zagreb 10000, Croatia.
   [Hermanns, Norbert] Forschungsinst Diabet Akad Bad Mergentheim FIDAM, D-97980 Bad Mergentheim, Germany.
RP Lovrencic, MV (corresponding author), Merkur Univ Hosp, Dept Lab Med, Zajceva 19, Zagreb 10000, Croatia.
EM vucic@idb.hr
RI Sekerija, Mario/W-8550-2019; Hermanns, Norbert/AAG-7060-2020
OI Hermanns, Norbert/0000-0002-2903-2677; Vucic Lovrencic,
   Marijana/0000-0001-7365-0627
FU European Foundation for the Study of Diabetes (EFSD)-New Horizons
   Collaborative Research Initiative
FX The study was funded by the European Foundation for the Study of
   Diabetes (EFSD)-New Horizons Collaborative Research Initiative 2010. The
   authors would like to thank Lovorka Perkovic, Croatian Institute of
   Public Health, for editing the paper.
CR Abramson Joseph H, 2011, Epidemiol Perspect Innov, V8, P1, DOI 10.1186/1742-5573-8-1
   Ali S, 2006, DIABETIC MED, V23, P1165, DOI 10.1111/j.1464-5491.2006.01943.x
   [Anonymous], 2015, OB OV
   Arroll B, 2005, BRIT MED J, V331, P884, DOI 10.1136/bmj.38607.464537.7C
   Aschbacher K, 2013, PSYCHONEUROENDOCRINO, V38, P1698, DOI 10.1016/j.psyneuen.2013.02.004
   Baumeister H, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008381.pub2
   Berk M, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-200
   Black SA, 2003, DIABETES CARE, V26, P2822, DOI 10.2337/diacare.26.10.2822
   Bonakdaran S, 2014, CURR DIABETES REV, V10, P113, DOI 10.2174/1573399810666140228160938
   Bot M, 2010, DIABETIC MED, V27, P1295, DOI 10.1111/j.1464-5491.2010.03119.x
   Broedbaek K, 2011, FREE RADICAL BIO MED, V51, P1473, DOI 10.1016/j.freeradbiomed.2011.07.007
   Browning LM, 2004, INT J OBESITY, V28, P1004, DOI 10.1038/sj.ijo.0802711
   Chen HY, 2011, KIDNEY INT, V80, P415, DOI 10.1038/ki.2011.151
   COHEN J, 1992, PSYCHOL BULL, V112, P155, DOI 10.1037/0033-2909.112.1.155
   De Giorgi A, 2015, EUR REV MED PHARMACO, V19, P640
   de Groot M, 2001, PSYCHOSOM MED, V63, P619, DOI 10.1097/00006842-200107000-00015
   de Kort S, 2011, OBES REV, V12, P449, DOI 10.1111/j.1467-789X.2010.00845.x
   de Lemos ET, 2012, OXID MED CELL LONGEV, V2012, DOI 10.1155/2012/741545
   Desideri G, 2014, EUR REV MED PHARMACO, V18, P1295
   Doyle TA, 2013, J PSYCHOSOM RES, V75, P419, DOI 10.1016/j.jpsychores.2013.08.006
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   Evans MD, 2008, FREE RADICAL RES, V42, P831, DOI 10.1080/10715760802506323
   Fisher L, 2013, DIABETES CARE, V36, P2551, DOI 10.2337/dc12-2493
   Fontana L, 2014, AGING CELL, V13, P391, DOI 10.1111/acel.12207
   Forlenza MJ, 2006, PSYCHOSOM MED, V68, P1, DOI 10.1097/01.psy.0000195780.37277.2a
   Gavella M, 2003, ACTA DIABETOL, V40, P95
   Gold PW, 2015, MOL PSYCHIATR, V20, P32, DOI 10.1038/mp.2014.163
   Gopaul KP, 2006, CLIN BIOCHEM, V39, P667, DOI 10.1016/j.clinbiochem.2006.02.010
   Harkness E, 2010, DIABETES CARE, V33, P926, DOI 10.2337/dc09-1519
   Hermanns N, 2015, DIABETES CARE, V38, P551, DOI 10.2337/dc14-1416
   Hutcheson R, 2012, EXP DIABETES RES, DOI 10.1155/2012/271028
   Ismail K, 2007, DIABETES CARE, V30, P1473, DOI 10.2337/dc06-2313
   Johnson RJ, 2013, DIABETES, V62, P3307, DOI 10.2337/db12-1814
   Jorgensen A, 2013, J AFFECT DISORDERS, V149, P355, DOI 10.1016/j.jad.2013.02.011
   Kéri S, 2014, BRAIN BEHAV IMMUN, V40, P235, DOI 10.1016/j.bbi.2014.03.020
   Kroenke K, 2003, MED CARE, V41, P1284, DOI 10.1097/01.MLR.0000093487.78664.3C
   Laake JPS, 2014, DIABETES CARE, V37, P2186, DOI 10.2337/dc13-2522
   Lustman PJ, 2000, DIABETES CARE, V23, P934, DOI 10.2337/diacare.23.7.934
   Maes M, 2011, PROG NEURO-PSYCHOPH, V35, P784, DOI 10.1016/j.pnpbp.2010.06.023
   Nefs G, 2012, DIABETOLOGIA, V55, P608, DOI 10.1007/s00125-011-2411-2
   Nojima H, 2008, METABOLISM, V57, P170, DOI 10.1016/j.metabol.2007.08.021
   Palta P, 2014, PSYCHOSOM MED, V76, P12, DOI 10.1097/PSY.0000000000000009
   Pibernik-Okanovic M, 2013, DIABETOLOGIA, V56, pS465
   Pibernik-Okanovic M, 2008, J DIABETES COMPLICAT, V22, P246, DOI 10.1016/j.jdiacomp.2007.03.002
   Pibernik-Okanovic M, 2011, TRIALS, V12, DOI 10.1186/1745-6215-12-17
   Pibernik-Okanovic M, 2009, TRIALS, V10, DOI 10.1186/1745-6215-10-78
   Poulsen HE, 2014, BBA-GEN SUBJECTS, V1840, P801, DOI 10.1016/j.bbagen.2013.06.009
   Purkayastha S, 2013, MOL METAB, V2, P356, DOI 10.1016/j.molmet.2013.09.005
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Richardson LK, 2008, GEN HOSP PSYCHIAT, V30, P509, DOI 10.1016/j.genhosppsych.2008.07.001
   Rochette L, 2014, BBA-GEN SUBJECTS, V1840, P2709, DOI 10.1016/j.bbagen.2014.05.017
   Rohde P, 1997, AM J PSYCHIAT, V154, P1593, DOI 10.1176/ajp.154.11.1593
   Rohleder N, 2014, PSYCHOSOM MED, V76, P181, DOI 10.1097/PSY.0000000000000049
   Sharpley CF, 2010, PSYCHOTHERAPY, V47, P603, DOI 10.1037/a0021177
   Silverman MN, 2014, INTERFACE FOCUS, V4, DOI 10.1098/rsfs.2014.0040
   Thornton LM, 2009, PSYCHOSOM MED, V71, P715, DOI 10.1097/PSY.0b013e3181b0545c
   Turer AT, 2012, DIABETOLOGIA, V55, P2319, DOI 10.1007/s00125-012-2598-x
   Varki A, 2012, ANN NY ACAD SCI, V1253, P16, DOI 10.1111/j.1749-6632.2012.06517.x
   Vucic M, 1997, HORM METAB RES, V29, P355, DOI 10.1055/s-2007-979053
   Wahlqvist ML, 2013, ASIA PAC J CLIN NUTR, V22, P171, DOI 10.6133/apjcn.2013.22.2.21
   Yi SY, 2012, PSYCHIAT RES, V200, P318, DOI 10.1016/j.psychres.2012.05.035
   Zhang XP, 2005, AM J EPIDEMIOL, V161, P652, DOI 10.1093/aje/kwi089
NR 62
TC 14
Z9 15
U1 1
U2 12
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2015
VL 2015
AR 210406
DI 10.1155/2015/210406
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CP8MJ
UT WOS:000360147700001
PM 26347775
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Anupam, S
   Goel, S
   Bhatti, K
   Mehta, DK
   Das, R
AF Anupam, Sristi
   Goel, Simran
   Bhatti, Karun
   Mehta, Dinesh Kumar
   Das, Rina
TI Serum Gamma Glutamyl Transferase: Understanding its Contribution as a
   Potential Predictor of the Occurrence of Type 2 Diabetes
SO CURRENT DIABETES REVIEWS
LA English
DT Review
DE Gamma-glutamyl transpeptidase; glutathione; dimeric glycoprotein;
   hydrophobic; oxidative stress; metabolic syndrome
ID LIVER-ENZYMES; ALANINE AMINOTRANSFERASE; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; LIFE-STYLE; MELLITUS; RISK; TRANSPEPTIDASE; ASSOCIATION;
   PREVALENCE
AB Introduction The liver and kidneys are the primary locations of the glutathione metabolism enzyme gamma-glutamyl transferase (GGT). The two main factors contributing to an increase are hepatic illnesses and excessive alcohol use. This study set out to test a theory on the predictive importance of the association between GGT and Type 2 diabetes mellitus. (T2DM).Methods In order to do this, we combed through PubMed, Google Scholar, Medline, and Science Direct for a wide range of information from previous studies. Attributes were established at the outset and compared to GGT concentration.Results GGT, present in most cells, absorbs glutathione for intracellular antioxidant defences. This study links GGT to hepatic enzymes including HDL, LDL, and triglyceride. LDL, triglycerides, AST, and ALT increased with GGT concentration, but LDL decreased. Because of obesity, GGT production rises with BMI. We found that greater GGT levels were associated with more T2DM after analysing data from multiple sources.Conclusion This literature review concludes that GGT is related to other factors such as BMI, HDL, AST, and triglycerides in the development of diabetes mellitus. Serum GGT was found to be a potential predictor of metabolic syndrome and T2DM.
C1 [Anupam, Sristi; Goel, Simran; Mehta, Dinesh Kumar; Das, Rina] Maharishi Markandeshwar Deemed Univ, MM Coll Pharm, Ambala, Haryana, India.
   [Bhatti, Karun] Maharishi Markandeshwar Deemed Univ, MM Inst Med Sci & Res, Dept Med, Ambala, Haryana, India.
C3 Maharishi Markandeshwar University; Maharishi Markandeshwar University
RP Das, R (corresponding author), Maharishi Markandeshwar Deemed Univ, MM Coll Pharm, Ambala, Haryana, India.
EM rinammu@gmail.com
RI Mehta, Dinesh Kumar/AAY-5941-2021; Das, Rina/AAX-4943-2021
OI das, rina/0000-0002-2535-2729
CR Abbasi A, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051496
   Agarwal H., 2018, Int J. Sci. Res. (IJSR) ISSN: 2319-7064 ResearchGate Impact Factor
   Aggarwal J., 2019, Int J Clin Biochem Research, V6, P336, DOI [10.18231/j.ijcbr.2019.073, DOI 10.18231/J.IJCBR.2019.073]
   Ahn HR, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-14
   André P, 2005, DIABETES METAB, V31, P542, DOI 10.1016/S1262-3636(07)70229-X
   [Anonymous], 1998, Harrison's Principles of Internal Medicine, V14th
   [Anonymous], 2021, Int. J. Health Sci. Res, DOI [10.52403/ijhsr.20210929, DOI 10.52403/IJHSR.20210929]
   Bandara D., 2022, Ceylon Journal of Medical Science, V57, P36, DOI [10.4038/cjms.v57i1.4970, DOI 10.4038/CJMS.V57I1.4970]
   Belkacemi L, 2016, DIABETES METAB SYND, V10, pS147, DOI 10.1016/j.dsx.2015.10.013
   Bi YR, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.899008
   Blaha M., 2006, CLIN DIABETES, V24, P125
   Brenner H, 1997, PREV MED, V26, P305, DOI 10.1006/pmed.1997.0144
   Chatterjee S, 2017, LANCET, V389, P2239, DOI 10.1016/S0140-6736(17)30058-2
   Chen L, 2012, NAT REV ENDOCRINOL, V8, P228, DOI 10.1038/nrendo.2011.183
   Choi SH, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000018963
   Dhankhar S, 2023, DIABETOL METAB SYNDR, V15, DOI 10.1186/s13098-023-00983-5
   Doi Y, 2007, OBESITY, V15, P1841, DOI 10.1038/oby.2007.218
   Evans JL, 2003, DIABETES, V52, P1, DOI 10.2337/diabetes.52.1.1
   FINIDORI J, 1984, J BIOL CHEM, V259, P4687
   Fischbach F., 2004, MANUAL LAB DIAGNOSTI, V7th
   Forlani G, 2008, J ENDOCRINOL INVEST, V31, P146, DOI 10.1007/BF03345581
   Gaeini Z, 2020, HEPAT MON, V20, DOI 10.5812/hepatmon.98535
   Genetic basis of type 1 and type 2 diabetes obesity and their complications., a Strategic Planning report of the DMICC
   HANIGAN MH, 1985, CARCINOGENESIS, V6, P165, DOI 10.1093/carcin/6.2.165
   HANIGAN MH, 1993, BIOCHEMISTRY-US, V32, P6302, DOI 10.1021/bi00075a026
   Hu FB, 2001, NEW ENGL J MED, V345, P790, DOI 10.1056/NEJMoa010492
   Hu HF, 2022, J DIABETES INVEST, DOI 10.1111/jdi.13900
   Islam S, 2020, ENDOCRIN DIAB METAB, V3, DOI 10.1002/edm2.116
   Itabashi F, 2022, J EPIDEMIOL, V32, P221, DOI 10.2188/jea.JE20200384
   Kaneko K, 2019, J DIABETES INVEST, V10, P837, DOI 10.1111/jdi.12930
   Karimabad MN, 2022, BMC ENDOCR DISORD, V22, DOI 10.1186/s12902-022-01042-2
   Kim CH, 2009, DIABETES-METAB RES, V25, P64, DOI 10.1002/dmrr.890
   labtestsonline, 2015, A public service on clinical lab testing from the laboratory professionals who do the testing, Internet description of GGT provided by Lab Tests Online
   Lee SH, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000006901
   Lsb D., 2021, Int. J. Endocrinol. Metab. Disord, V7, DOI [10.16966/2380-548X.175, DOI 10.16966/2380-548X.175]
   Miyamori D, 2021, ENDOCR J, V68, P1391, DOI 10.1507/endocrj.EJ20-0823
   Nakanishi N, 2004, DIABETES CARE, V27, P1427, DOI 10.2337/diacare.27.6.1427
   Nakanishi N, 2003, J INTERN MED, V254, P287, DOI 10.1046/j.1365-2796.2003.01198.x
   Nannipieri M, 2005, DIABETES CARE, V28, P1757, DOI 10.2337/diacare.28.7.1757
   Pagana KD, 2019, MOSBYS DIAGNOSTIC LA
   Philip R, 2014, NITTE UNIV J HEALTH, V4, P90
   Sah KK, 2022, J YOUNG PHARM, V14, P416, DOI 10.5530/jyp.2022.14.84
   Schellenberg ES, 2013, ANN INTERN MED, V159, P543, DOI 10.7326/0003-4819-159-8-201310150-00007
   Sharmin F, 2021, Mymensingh Med J, V30, P973
   Singh A., 2021, Curr. Chem. Biol., V15, P128
   TATE SS, 1981, MOL CELL BIOCHEM, V39, P357, DOI 10.1007/BF00232585
   Tohidi Maryam, 2008, BMC Endocr Disord, V8, P5, DOI 10.1186/1472-6823-8-5
   Valizadeh N., 2018, Shiraz E Medical Journal, V19, pe64073, DOI 10.5812/semj.64073
   Wang X, 2022, J CLIN ENDOCR METAB, V107, pE4086, DOI 10.1210/clinem/dgac438
   Wang YL, 2016, BMJ OPEN DIAB RES CA, V4, DOI 10.1136/bmjdrc-2016-000296
   Wang Y, 2021, METAB SYNDR RELAT D, V19, P100, DOI 10.1089/met.2020.0032
   Whitfield JB, 2001, CRIT REV CL LAB SCI, V38, P263, DOI 10.1080/20014091084227
   Wickham S, 2011, ANAL BIOCHEM, V414, P208, DOI 10.1016/j.ab.2011.03.026
   Xu L, 2015, J EPIDEMIOL COMMUN H, V69, P1040, DOI 10.1136/jech-2015-205518
   Zheng Y, 2018, NAT REV ENDOCRINOL, V14, P88, DOI 10.1038/nrendo.2017.151
   Zhou B, 2016, LANCET, V387, P1513, DOI 10.1016/S0140-6736(16)00618-8
NR 56
TC 3
Z9 3
U1 1
U2 3
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-3998
EI 1875-6417
J9 CURR DIABETES REV
JI Curr. Diabetes Reviews
PY 2025
VL 21
IS 1
AR E240124226080
DI 10.2174/0115733998260996231122054907
PG 9
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA J2X5D
UT WOS:001335747000004
PM 38275034
DA 2025-06-11
ER

PT J
AU Zhou, SY
   Zhao, K
   Shi, X
   Sun, HK
   Du, SY
   Miao, XM
   Chen, JJ
   Yang, F
   Xing, MZ
   Ran, W
   Lao, JY
   Zhang, XY
   Wang, W
   Tang, W
AF Zhou, Siyao
   Zhao, Ke
   Shi, Xiang
   Sun, Huankun
   Du, Siyu
   Miao, Xuemeng
   Chen, Jianjun
   Yang, Fan
   Xing, Minzhi
   Ran, Wang
   Lao, Jiaying
   Zhang, Xiangyang
   Wang, Wei
   Tang, Wei
TI Serum Lipid Levels and Suicide Attempts Within 2 Weeks in Patients With
   Major Depressive Disorder: Is There a Relationship?
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE depression; suicide unattempted; serum lipid profiles; psychotic;
   indicator
ID DRUG-NAIVE PATIENTS; CHOLESTEROL CONCENTRATION; METABOLIC SYNDROME;
   RISK-FACTOR; HDL-C; ASSOCIATION; MORTALITY; MEN; METAANALYSIS;
   1ST-EPISODE
AB The potential correlation between serum lipid profiles and suicidal tendencies has been previously reported, however, it is unclear whether serum lipid profiles have definite relevance to recently attempted suicides in individuals suffering from major depressive disorder (MDD). In this study, the relationship between blood lipids and suicide attempts in first-episode MDD patients in research were used to examine whether there is a connection. The cross-sectional study recruited 580 patients at the time of their first episode, measuring up to the diagnostic standard of MDD. Baseline demographic, clinical data, and blood lipid level data were collected. Depression severity was measured with the Hamilton Depression Rating Scale (HAMD). Our results revealed that the level of TC may be identified as a promising and effective biomarker for first-episode MDD suicide risk, suggesting that screening of serum lipid profiles in depressive patients is essential for suicide prevention.
C1 [Zhou, Siyao; Zhao, Ke; Shi, Xiang; Sun, Huankun; Du, Siyu; Miao, Xuemeng; Chen, Jianjun; Yang, Fan; Xing, Minzhi; Ran, Wang; Lao, Jiaying; Wang, Wei] Wenzhou Med Univ, Sch Mental Hlth, Wenzhou, Peoples R China.
   [Zhang, Xiangyang] Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China.
   [Zhang, Xiangyang] Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China.
   [Tang, Wei] Wenzhou Med Univ, Affiliated Kangning Hosp, Wenzhou, Peoples R China.
C3 Wenzhou Medical University; Chinese Academy of Sciences; Institute of
   Psychology, CAS; Chinese Academy of Sciences; University of Chinese
   Academy of Sciences, CAS; Wenzhou Medical University
RP Wang, W (corresponding author), Wenzhou Med Univ, Sch Mental Hlth, Wenzhou, Peoples R China.; Tang, W (corresponding author), Wenzhou Med Univ, Affiliated Kangning Hosp, Wenzhou, Peoples R China.
EM wangwei@wmu.edu.cn; tangweikn@163.com
RI Lao, Jiaying/LDF-1176-2024; Wang, Wei/AID-3772-2022; Zhang,
   Xiangyang/ABC-7380-2022
OI Zhang, Xiangyang/0000-0003-3326-382X
FU Wenzhou Science and Technology Project [Y20180115]; Natural Science
   Foundation of Zhejiang Province [LQ18H090009]; medical and health
   research project of Zhejiang province [2020KY926]; Zhejiang Province
   Science and Technology Plan Research and Xinmiao Talent Program
   [2020R413073]
FX This work was supported by the Wenzhou Science and Technology Project
   (Y20180115), the Natural Science Foundation of Zhejiang Province
   (LQ18H090009), the medical and health research project of Zhejiang
   province (2020KY926), and Zhejiang Province Science and Technology Plan
   Research and Xinmiao Talent Program (2020R413073).
CR Ananloo ES, 2013, DARU, V21, DOI 10.1186/2008-2231-21-4
   Apter A, 1999, BIOL PSYCHIAT, V46, P532, DOI 10.1016/S0006-3223(98)00345-X
   Arensman E, 2020, CRISIS, V41, pS3, DOI 10.1027/0227-5910/a000664
   Asellus P, 2010, J AFFECT DISORDERS, V125, P388, DOI 10.1016/j.jad.2010.02.111
   Baek JH, 2014, PROG NEURO-PSYCHOPH, V51, P113, DOI 10.1016/j.pnpbp.2014.01.018
   Battle DE, 2013, CODAS, V25, P191
   Black C, 2015, BIOL PSYCHIAT, V78, P28, DOI 10.1016/j.biopsych.2014.10.014
   Bocchetta A, 2001, ACTA PSYCHIAT SCAND, V104, P37, DOI 10.1034/j.1600-0447.2001.00374.x
   Boston PF, 1996, BRIT J PSYCHIAT, V169, P682, DOI 10.1192/bjp.169.6.682
   Brown BG, 2007, J CLIN LIPIDOL, V1, P88, DOI 10.1016/j.jacl.2007.02.004
   Brunner Jurgen, 2006, Arch Suicide Res, V10, P1, DOI 10.1080/13811110500318083
   Cantarelli MD, 2015, J AFFECT DISORDERS, V172, P403, DOI 10.1016/j.jad.2014.10.033
   Chen CC, 2001, PSYCHIAT RES, V102, P153, DOI 10.1016/S0165-1781(01)00231-1
   D'Ambrosio V, 2012, PROG NEURO-PSYCHOPH, V37, P136, DOI 10.1016/j.pnpbp.2011.12.009
   De Berardis D, 2020, BRAIN SCI, V10, DOI 10.3390/brainsci10090591
   De Berardis D, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19102888
   De Berardis D, 2017, FRONT PSYCHIATRY, V8, DOI 10.3389/fpsyt.2017.00148
   De Berardis D, 2014, REV BRAS PSIQUIATR, V36, P125, DOI 10.1590/1516-4446-2013-1189
   de Leon J, 2011, ANN CLIN PSYCHIATRY, V23, P163
   Dong M, 2018, J AFFECT DISORDERS, V225, P32, DOI 10.1016/j.jad.2017.07.043
   Fiedorowicz JG, 2007, PSYCHIAT RES, V152, P11, DOI 10.1016/j.psychres.2006.09.003
   Friedrich M J, 2017, JAMA, V317, P1517, DOI 10.1001/jama.2017.3826
   GOLIER JA, 1995, AM J PSYCHIAT, V152, P419
   Golomb BA, 2004, CONTROL CLIN TRIALS, V25, P178, DOI 10.1016/j.cct.2003.08.014
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   HAMILTON M, 1959, BRIT J MED PSYCHOL, V32, P50, DOI 10.1111/j.2044-8341.1959.tb00467.x
   Hegerl U, 2001, J AFFECT DISORDERS, V62, P93, DOI 10.1016/S0165-0327(00)00353-0
   Huang T L, 2001, Chang Gung Med J, V24, P563
   Huang TL, 2005, J AFFECT DISORDERS, V86, P75, DOI 10.1016/j.jad.2004.11.005
   Jointer TE, 2003, BEHAV RES THER, V41, P1469, DOI 10.1016/S0005-7967(03)00070-6
   Kim YK, 2004, J AFFECT DISORDERS, V81, P161, DOI 10.1016/S0165-0327(03)00166-6
   Kuwano N, 2018, J AFFECT DISORDERS, V231, P74, DOI 10.1016/j.jad.2018.01.014
   Lalovic A, 2007, INT J NEUROPSYCHOPH, V10, P159, DOI 10.1017/S1461145706006663
   Leweke F, 2012, PSYCHOPATHOLOGY, V45, P22, DOI 10.1159/000325170
   LINDBERG G, 1992, BRIT MED J, V305, P277, DOI 10.1136/bmj.305.6848.277
   Lindqvist D, 2009, BIOL PSYCHIAT, V66, P287, DOI 10.1016/j.biopsych.2009.01.030
   MAES M, 1994, AM J PSYCHIAT, V151, P112
   MAES M, 1994, ACTA PSYCHIAT SCAND, V90, P252, DOI 10.1111/j.1600-0447.1994.tb01589.x
   Maes M, 1997, ACTA PSYCHIAT SCAND, V95, P212, DOI 10.1111/j.1600-0447.1997.tb09622.x
   Mann JJ, 1996, NEUROPSYCHOPHARMACOL, V15, P576, DOI 10.1016/S0893-133X(96)00102-9
   Mead GE, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004366.pub4
   MULDOON MF, 1990, BMJ-BRIT MED J, V301, P309, DOI 10.1136/bmj.301.6747.309
   NEATON JD, 1992, ARCH INTERN MED, V152, P1490, DOI 10.1001/archinte.152.7.1490
   O'Donovan A, 2013, DEPRESS ANXIETY, V30, P307, DOI 10.1002/da.22087
   Oh J, 2017, J AFFECT DISORDERS, V213, P51, DOI 10.1016/j.jad.2017.02.002
   Orsolini L, 2020, PSYCHIAT INVEST, V17, P207, DOI 10.30773/pi.2019.0171
   Pandey GN, 2013, BIPOLAR DISORD, V15, P524, DOI 10.1111/bdi.12089
   Park S, 2013, BEHAV BRAIN FUNCT, V9, DOI 10.1186/1744-9081-9-45
   de Melo LGP, 2017, PROG NEURO-PSYCHOPH, V78, P34, DOI 10.1016/j.pnpbp.2017.04.027
   Pompili M, 2010, PSYCHOL REP, V106, P785, DOI 10.2466/PR0.106.3.785-790
   Segoviano-Mendoza M, 2018, BMC PSYCHIATRY, V18, DOI 10.1186/s12888-018-1596-z
   Shen YM, 2019, J AFFECT DISORDERS, V259, P180, DOI 10.1016/j.jad.2019.08.067
   SULLIVAN PF, 1994, BIOL PSYCHIAT, V36, P472, DOI 10.1016/0006-3223(94)90643-2
   Udina M, 2012, J CLIN PSYCHIAT, V73, P1128, DOI 10.4088/JCP.12r07694
   Wagner CJ, 2019, PROG NEURO-PSYCHOPH, V92, P405, DOI 10.1016/j.pnpbp.2019.01.010
   Wu SQ, 2016, J PSYCHIATR NEUROSCI, V41, P56, DOI 10.1503/jpn.150079
NR 56
TC 13
Z9 14
U1 0
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JUN 7
PY 2021
VL 12
AR 676040
DI 10.3389/fpsyt.2021.676040
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA SW6HG
UT WOS:000664614200001
PM 34163387
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sundaram, SS
   Halbower, AC
   Klawitter, J
   Pan, ZX
   Robbins, K
   Capocelli, KE
   Sokol, RJ
AF Sundaram, Shikha S.
   Halbower, Ann C.
   Klawitter, Jelena
   Pan, Zhaoxing
   Robbins, Kristen
   Capocelli, Kelley E.
   Sokol, Ronald J.
TI Treating Obstructive Sleep Apnea and Chronic Intermittent Hypoxia
   Improves the Severity of Nonalcoholic Fatty Liver Disease in Children
SO JOURNAL OF PEDIATRICS
LA English
DT Article
ID POSITIVE AIRWAY PRESSURE; SERUM AMINOTRANSFERASE LEVELS;
   INSULIN-RESISTANCE; DAYTIME SLEEPINESS; LEPTIN LEVELS; CPAP;
   STEATOHEPATITIS; HEPATITIS; RISK; 15-F-2T-ISOPROSTANE
AB Objective To determine the effects of treating obstructive sleep apnea/nocturnal hypoxia on pediatric nonalcoholic fatty liver disease (NAFLD) severity and oxidative stress.
   Study design Biopsy proven participants (n = 9) with NAFLD and obstructive sleep apnea/hypoxia were studied before and after treatment with continuous positive airway pressure (CPAP) for sleep disordered breathing, including laboratory testing and markers of oxidative stress, urine F(2)-isoprostanes.
   Results Adolescents (age 11.5 +/- 1.2 years; body mass index, 29.5 +/- 3.8 kg/m(2)) with significant NAFLD (mean histologic necroinflammation grade, 2.3 +/- 0.9; fibrosis stage, 1.4 +/- 1.3; NAFLD Activity Score summary, 4.8 +/- 1.6) had obstructive sleep apnea/hypoxia by polysomnography. At baseline, they had severe obstructive sleep apnea/hypoxia, elevated aminotransferases, the metabolic syndrome, and significant oxidative stress (high F(2)-isoprostanes). Obstructive sleep apnea/hypoxia was treated with home CPAP for a mean 89 +/- 62 days. Although body mass index increased, obstructive sleep apnea/hypoxia severity improved on CPAP and was accompanied by reduced alanine aminotransferase, metabolic syndrome markers. and F(2)-isoprostanes.
   Conclusions This study provides strong evidence that treatment of obstructive sleep apnea/nocturnal hypoxia with CPAP in children with NAFLD may reverse parameters of liver injury and reduce oxidative stress. These data also suggest CPAP as a new therapy to prevent progression of NAFLD in those children with obesity found to have obstructive sleep apnea/nocturnal hypoxia.
C1 [Sundaram, Shikha S.; Robbins, Kristen; Sokol, Ronald J.] Childrens Hosp Colorado, Sect Gastroenterol Hepatol & Nutr, Dept Pediat, Aurora, CO USA.
   [Sundaram, Shikha S.; Robbins, Kristen; Sokol, Ronald J.] Childrens Hosp Colorado, Digest Hlth Inst, 13123 E 16th Ave,B290, Aurora, CO 80045 USA.
   [Sundaram, Shikha S.; Robbins, Kristen; Sokol, Ronald J.] Univ Colorado, Sch Med, Aurora, CO USA.
   [Halbower, Ann C.] Childrens Hosp Colorado, Sect Pulm Med, Dept Pediat, Aurora, CO USA.
   [Halbower, Ann C.; Pan, Zhaoxing] Univ Colorado, Sch Med, Anschutz Med Ctr, Aurora, CO USA.
   [Klawitter, Jelena] Univ Colorado, Clin Res & Dev IC42, Dept Anesthesiol, Sch Med, Aurora, CO USA.
   [Pan, Zhaoxing] Childrens Hosp Colorado, Biostat Core Res Inst, Aurora, CO USA.
   [Capocelli, Kelley E.] Univ Colorado, Pediat Pathol, Dept Pathol, Sch Med, Aurora, CO USA.
C3 Children's Hospital Colorado; Children's Hospital Colorado; University
   of Colorado System; University of Colorado Anschutz Medical Campus;
   Children's Hospital Colorado; University of Colorado System; University
   of Colorado Anschutz Medical Campus; University of Colorado System;
   University of Colorado Anschutz Medical Campus; Children's Hospital
   Colorado; University of Colorado System; University of Colorado Anschutz
   Medical Campus
RP Sundaram, SS (corresponding author), Childrens Hosp Colorado, Digest Hlth Inst, 13123 E 16th Ave,B290, Aurora, CO 80045 USA.
EM shikha.sundaram@childrenscolorado.org
OI Sokol, Ronald/0000-0001-7433-4095
FU National Institutes of Health (NIH) [K23 DK085150]; NIH/NCATS Colorado
   CTSA [UL1TR001082]
FX Supported by the National Institutes of Health (NIH, K23 DK085150) and
   NIH/NCATS Colorado CTSA (UL1TR001082). Its contents are the authors'
   sole responsibility and do not necessarily represent official NIH views.
   The authors declare no conflicts of interest.
CR Angulo P, 2002, NEW ENGL J MED, V346, P1221, DOI 10.1038/nrdp.2015.80
   Auwerx J, 1998, LANCET, V351, P737, DOI 10.1016/S0140-6736(97)06348-4
   Babior BM, 2000, AM J MED, V109, P33, DOI 10.1016/S0002-9343(00)00481-2
   Barceló A, 2006, EUR RESPIR J, V27, P756, DOI 10.1183/09031936.06.00067605
   Berry RB, 2012, J CLIN SLEEP MED, V8, P597, DOI 10.5664/jcsm.2172
   Brunt EM, 1999, AM J GASTROENTEROL, V94, P2467, DOI 10.1111/j.1572-0241.1999.01377.x
   Brunt EM, 2001, SEMIN LIVER DIS, V21, P3, DOI 10.1055/s-2001-12925
   Chen LD, 2018, CLIN RESPIR J, V12, P373, DOI 10.1111/crj.12554
   Chin K, 2003, AM J MED, V114, P370, DOI 10.1016/S0002-9343(02)01570-X
   Chin KZ, 1999, CIRCULATION, V100, P706, DOI 10.1161/01.CIR.100.7.706
   COHEN J, 1992, PSYCHOL BULL, V112, P155, DOI 10.1037/0033-2909.112.1.155
   Colombo O, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-13
   Considine RV, 1996, NEW ENGL J MED, V334, P292, DOI 10.1056/NEJM199602013340503
   Coughlin SR, 2007, EUR RESPIR J, V29, P720, DOI 10.1183/09031936.00043306
   Dorkova Z, 2008, CHEST, V134, P686, DOI 10.1378/chest.08-0556
   Drager LF, 2011, OBESITY, V19, P2167, DOI 10.1038/oby.2011.240
   Drake C, 2003, SLEEP, V26, P455
   Feranchak AP, 1999, J PEDIATR-US, V135, P601, DOI 10.1016/S0022-3476(99)70059-4
   Halbower AC, 2007, CHEST, V132, P2030, DOI 10.1378/chest.06-2827
   Haschke M, 2007, CLIN CHEM, V53, P489, DOI 10.1373/clinchem.2006.078972
   Hawkins SMM, 2016, J CLIN SLEEP MED, V12, P879, DOI 10.5664/jcsm.5892
   Henrion J, 1997, J CLIN GASTROENTEROL, V24, P245, DOI 10.1097/00004836-199706000-00013
   HEUBI JE, 1990, J PEDIATR GASTR NUTR, V10, P468, DOI 10.1097/00005176-199005000-00009
   Hoyos CM, 2012, THORAX, V67, P1081, DOI 10.1136/thoraxjnl-2011-201420
   Ip MSM, 2000, CHEST, V118, P580, DOI 10.1378/chest.118.3.580
   Joosten KF, 2017, PEDIATR PULM, V52, P260, DOI 10.1002/ppul.23639
   Jullian-Desayes I, 2016, RESPIROLOGY, V21, P378, DOI 10.1111/resp.12672
   Kaditis AG, 2016, EUR RESPIR J, V47, P69, DOI 10.1183/13993003.00385-2015
   Kheirandish-Gozal L, 2008, CHEST, V133, P92, DOI 10.1378/chest.07-0773
   Klawitter J, 2011, RAPID COMMUN MASS SP, V25, P463, DOI 10.1002/rcm.4871
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Kohler M, 2009, RESPIRATION, V78, P141, DOI 10.1159/000170785
   Kuczmarski R J, 2000, Adv Data, P1
   Lavie L, 2004, SLEEP, V27, P123
   Lavine JE, 2011, JAMA-J AM MED ASSOC, V305, P1659, DOI 10.1001/jama.2011.520
   Li K, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000006850
   Marcus CL, 2012, PEDIATRICS, V130, P576, DOI 10.1542/peds.2012-1671
   MATHURIN P, 1995, GASTROENTEROLOGY, V109, P1682, DOI 10.1016/0016-5085(95)90659-2
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   MCCORD JM, 1985, NEW ENGL J MED, V312, P159
   Mitchel EB, 2014, ALIMENT PHARM THER, V40, P1155, DOI 10.1111/apt.12972
   Montgomery-Downs HE, 2006, PEDIATRICS, V117, P741, DOI 10.1542/peds.2005-1067
   Montuschi P, 2004, FASEB J, V18, P1791, DOI 10.1096/fj.04-2330rev
   Musso G, 2013, OBES REV, V14, P417, DOI 10.1111/obr.12020
   Nobili V, 2014, AM J RESP CRIT CARE, V189, P66, DOI 10.1164/rccm.201307-1339OC
   Phillips BG, 2000, AM J PHYSIOL-HEART C, V279, pH234, DOI 10.1152/ajpheart.2000.279.1.H234
   Polotsky M, 2012, J APPL PHYSIOL, V112, P1637, DOI 10.1152/japplphysiol.01222.2011
   Polotsky VY, 2009, AM J RESP CRIT CARE, V179, P228, DOI 10.1164/rccm.200804-608OC
   Savransky V, 2007, AM J PHYSIOL-GASTR L, V293, pG871, DOI 10.1152/ajpgi.00145.2007
   Schwimmer JB, 2006, PEDIATRICS, V118, P1388, DOI 10.1542/peds.2006-1212
   Sharma SK, 2011, NEW ENGL J MED, V365, P2277, DOI 10.1056/NEJMoa1103944
   Shpirer I, 2010, LUNG, V188, P301, DOI 10.1007/s00408-009-9219-6
   Sivam S, 2012, EUR RESPIR J, V40, P913, DOI 10.1183/09031936.00177011
   Sundaram SS, 2016, J HEPATOL, V65, P560, DOI 10.1016/j.jhep.2016.04.010
   Sundaram SS, 2014, J PEDIATR-US, V164, P699, DOI 10.1016/j.jpeds.2013.10.072
   Tan KCB, 2006, ATHEROSCLEROSIS, V184, P377, DOI 10.1016/j.atherosclerosis.2005.04.024
   Vgontzas AN, 2000, J CLIN ENDOCR METAB, V85, P1151, DOI 10.1210/jc.85.3.1151
   Warschburger P, 2016, BMC PEDIATR, V16, DOI 10.1186/s12887-016-0727-2
   West SD, 2007, THORAX, V62, P969, DOI 10.1136/thx.2006.074351
   Xie XM, 2013, SLEEP MED, V14, P1139, DOI 10.1016/j.sleep.2013.07.006
NR 60
TC 40
Z9 40
U1 1
U2 7
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
EI 1097-6833
J9 J PEDIATR-US
JI J. Pediatr.
PD JUL
PY 2018
VL 198
BP 67
EP +
DI 10.1016/j.jpeds.2018.03.028
PG 10
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA GL0XL
UT WOS:000436817000015
PM 29752170
DA 2025-06-11
ER

PT J
AU Kelly, AS
   Jacobs, DR
   Sinaiko, AR
   Moran, A
   Steffen, LM
   Steinberger, J
AF Kelly, Aaron S.
   Jacobs, David R., Jr.
   Sinaiko, Alan R.
   Moran, Antoinette
   Steffen, Lyn M.
   Steinberger, Julia
TI Relation of circulating oxidized LDL to obesity and insulin resistance
   in children
SO PEDIATRIC DIABETES
LA English
DT Article
DE children; insulin resistance; obesity; oxidized LDL
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-ARTERY-DISEASE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; RISK-FACTORS; ADULTS; DETERMINANTS; MARKERS; WOMEN;
   CLAMP
AB Introduction: Circulating oxidized low-density lipoprotein (LDL), a marker of oxidative stress, is associated with obesity, insulin resistance, metabolic syndrome, and cardiovascular disease in adults. However, little is known about its relation to insulin resistance and cardiovascular risk factors in children. The purpose of this study was to assess the relation of oxidative stress, measured by circulating oxidized LDL, with measures of adiposity and insulin resistance in children.
   Methods: Oxidized LDL, measures of body fatness (body mass index: BMI, percent body fat, waist circumference, percent trunk fat, abdominal visceral and subcutaneous fat), insulin resistance with euglycemic insulin clamp (Mlbm), blood pressure, and blood lipids were obtained in 78 children. Oxidized LDL was compared between normal weight children (BMI < 85th percentile) and overweight/obese children (BMI >= 85th percentile) and levels were evaluated for associations with body fatness and insulin resistance.
   Results: Oxidized LDL levels were significantly higher in overweight/obese vs. normal weight children (p < 0.0001). Oxidized LDL was significantly correlated with BMI, percent body fat, waist circumference, percent trunk fat, abdominal visceral fat, and abdominal subcutaneous fat (all p-values < 0.0001). Moreover, oxidized LDL was negatively correlated with Mlbm, even after adjustment for adiposity (p < 0.01).
   Conclusions: Oxidized LDL is significantly associated with adiposity and with insulin resistance, independent of body fatness, in children. Oxidative stress may be independently related to the development of insulin resistance early in life, especially in obese youth.
C1 [Kelly, Aaron S.] Univ Minnesota, Sch Med, Div Epidemiol & Clin Res, Dept Pediat, Minneapolis, MN 55455 USA.
   [Jacobs, David R., Jr.; Steffen, Lyn M.] Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN 55455 USA.
   [Jacobs, David R., Jr.] Univ Oslo, Dept Nutr, Oslo, Norway.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities;
   University of Oslo
RP Kelly, AS (corresponding author), Univ Minnesota, Sch Med, Div Epidemiol & Clin Res, Dept Pediat, 420 Delaware St SE,MMC 715, Minneapolis, MN 55455 USA.
EM kelly105@umn.edu
RI Jacobs, David/G-5405-2011
OI Steinberger, Julia/0000-0002-2892-8594; Jacobs,
   David/0000-0002-7232-0543; Steffen, Lyn M/0000-0002-4053-6729
FU University of Minnesota Vikings Children's; National Institutes of
   Health [1RO1DK072124-01A3]; NCRR/NIH [GCRC: M01-RR00400]
FX Funding for this study was provided by the University of Minnesota
   Vikings Children's Fund (A.S.K.), National Institutes of Health:
   1RO1DK072124-01A3 (J.S.), and GCRC: M01-RR00400, General Clinical
   Research Center Program, NCRR/NIH. Mercodia Inc. generously donated the
   competitive ELISA kits for oxidized LDL analysis.
CR Couillard C, 2005, J CLIN ENDOCR METAB, V90, P6454, DOI 10.1210/jc.2004-2438
   Demirel F, 2007, CLIN ENDOCRINOL, V67, P129, DOI 10.1111/j.1365-2265.2007.02849.x
   Ho RC, 2002, DIABETES, V51, pA300
   Holvoet P, 1998, CIRCULATION, V98, P1487, DOI 10.1161/01.CIR.98.15.1487
   Holvoet P, 2004, DIABETES, V53, P1068, DOI 10.2337/diabetes.53.4.1068
   Holvoet P, 2001, ARTERIOSCL THROM VAS, V21, P844, DOI 10.1161/01.ATV.21.5.844
   Holvoet P, 2008, JAMA-J AM MED ASSOC, V299, P2287, DOI 10.1001/jama.299.19.2287
   Holvoet P, 2007, ATHEROSCLEROSIS, V194, P245, DOI 10.1016/j.atherosclerosis.2006.08.002
   Itabe H, 2007, J ATHEROSCLER THROMB, V14, P1, DOI 10.5551/jat.14.1
   Järvisalo MJ, 2004, CIRCULATION, V109, P2885, DOI 10.1161/01.CIR.0000129304.98566.D8
   Kelishadi R, 2009, ATHEROSCLEROSIS, V204, P538, DOI 10.1016/j.atherosclerosis.2008.09.034
   Lapointe A, 2007, ATHEROSCLEROSIS, V191, P362, DOI 10.1016/j.atherosclerosis.2006.03.036
   Moran A, 1999, DIABETES, V48, P2039, DOI 10.2337/diabetes.48.10.2039
   Park K, 2009, DIABETES CARE, V32, P1302, DOI 10.2337/dc09-0259
   Sinaiko AR, 2001, J PEDIATR-US, V139, P700, DOI 10.1067/mpd.2001.118535
   Stringer DM, 2009, PEDIATR DIABETES, V10, P269, DOI 10.1111/j.1399-5448.2008.00473.x
   Van Guilder GP, 2006, OBESITY, V14, P2127, DOI 10.1038/oby.2006.248
   Weinbrenner T, 2006, AM J CLIN NUTR, V83, P30
   YUI S, 1993, ARTERIOSCLER THROMB, V13, P331, DOI 10.1161/01.ATV.13.3.331
NR 19
TC 60
Z9 66
U1 0
U2 8
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1399-543X
J9 PEDIATR DIABETES
JI Pediatr. Diabetes
PD DEC
PY 2010
VL 11
IS 8
BP 552
EP 555
DI 10.1111/j.1399-5448.2009.00640.x
PG 4
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA 688NA
UT WOS:000284854900007
PM 20102528
OA gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Razani, B
   Feng, C
   Semenkovich, CF
AF Razani, Babak
   Feng, Chu
   Semenkovich, Clay F.
TI p53 is required for chloroquine-induced atheroprotection but not insulin
   sensitization
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE atherosclerosis; insulin resistance; type 2 diabetes mellitus; genotoxic
   stress response; metabolic syndrome
ID SMOOTH-MUSCLE-CELLS; ATAXIA-TELANGIECTASIA; DNA-DAMAGE;
   CARDIOVASCULAR-DISEASE; SIGNALING PATHWAYS; METABOLIC SYNDROME;
   PIFITHRIN-ALPHA; PTEN EXPRESSION; CRUCIAL ROLE; ATHEROSCLEROSIS
AB An intact genotoxic stress response appears to be atheroprotective and insulin sensitizing. ATM, mutated in ataxia telangiectasia, is critical for the genotoxic stress response, and its deficiency is associated with accelerated atherosclerosis and insulin resistance in humans and mice. The antimalarial drug chloroquine activates ATM signaling and improves metabolic phenotypes in mice. p53 is a major effector of ATM signaling, but it is unknown if p53 is required for the beneficial effects of chloroquine. We tested the hypothesis that the cardiometabolic effects of chloroquine are p53-dependent. ApoE-null mice with or without p53 were treated with low-dose chloroquine or saline in the setting of a Western diet. After 8 weeks, there was no p53-dependent or chloroquine-specific effect on serum lipids or body weight. Chloroquine reduced plaque burden in mice wild-type for p53, but it did not decrease lesion extent in p53-null mice. However, chloroquine improved glucose tolerance, enhanced insulin sensitivity, and increased hepatic Akt signaling regardless of the p53 genotype. These results indicate that atheroprotection induced by chloroquine is p53-dependent but the insulin-sensitizing effects of this agent are not. Discrete components of the genotoxic stress response might be targeted to treat lipid- driven disorders, such as diabetes and atherosclerosis.-Razani, B., C. Feng, and C. F. Semenkovich. p53 is required for chloroquine-induced atheroprotection but not insulin sensitization. J. Lipid Res. 2010. 51: 1738-1746.
C1 [Razani, Babak; Feng, Chu; Semenkovich, Clay F.] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA.
   [Semenkovich, Clay F.] Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA.
C3 Washington University (WUSTL); Washington University (WUSTL)
RP Semenkovich, CF (corresponding author), Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA.
EM csemenko@wustl.edu
RI Segura-Aguilar, Juan/H-8839-2013
OI Razani, Babak/0000-0002-7172-9240; Semenkovich, Clay/0000-0003-1163-1871
FU National Institutes of Health (Clinical Nutrition Research Unit,
   Washington University) [P50-HL-083762, DK-076729, DK-56341]; National
   Institutes of Health (Diabetes Research and Training Center, Washington
   University) [DK-20579]; Physician Scientist Training Program and
   Cardiovascular Training Grant at Washington University
FX This work was supported by National Institutes of Health Grants
   P50-HL-083762, DK-076729, DK-56341 (Clinical Nutrition Research Unit,
   Washington University) and DK-20579 (Diabetes Research and Training
   Center, Washington University); and by the Physician Scientist Training
   Program and Cardiovascular Training Grant at Washington University. Its
   contents are solely the responsibility of the authors and do not
   necessarily represent the official views of the National Institutes of
   Health or other granting agencies.
CR Bakkenist CJ, 2003, NATURE, V421, P499, DOI 10.1038/nature01368
   BAR RS, 1978, NEW ENGL J MED, V298, P1164, DOI 10.1056/NEJM197805252982103
   Barry EF, 2009, J BIOL CHEM, V284, P12080, DOI 10.1074/jbc.M807637200
   Bensaad K, 2007, TRENDS CELL BIOL, V17, P286, DOI 10.1016/j.tcb.2007.04.004
   Canman CE, 1998, SCIENCE, V281, P1677, DOI 10.1126/science.281.5383.1677
   CHANG MW, 1995, SCIENCE, V267, P518, DOI 10.1126/science.7824950
   Corcoran CA, 2006, CANCER BIOL THER, V5, P1610, DOI 10.4161/cbt.5.12.3617
   Cowie CC, 2009, DIABETES CARE, V32, P287, DOI 10.2337/dc08-1296
   Febbraio M, 2000, J CLIN INVEST, V105, P1049, DOI 10.1172/JCI9259
   Feng ZH, 2007, CANCER RES, V67, P3043, DOI 10.1158/0008-5472.CAN-06-4149
   Green DR, 2006, CELL, V126, P30, DOI 10.1016/j.cell.2006.06.032
   Guevara NV, 1999, NAT MED, V5, P335, DOI 10.1038/6585
   HAFFNER SM, 1986, NEW ENGL J MED, V315, P220, DOI 10.1056/NEJM198607243150403
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Kastan MB, 2000, NAT REV MOL CELL BIO, V1, P179, DOI 10.1038/35043058
   Kastan MB, 2008, MOL CANCER RES, V6, P517, DOI 10.1158/1541-7786.MCR-08-0020
   Kyriakis JM, 2001, PHYSIOL REV, V81, P807, DOI 10.1152/physrev.2001.81.2.807
   LANE DP, 1992, NATURE, V358, P15, DOI 10.1038/358015a0
   Leker RR, 2004, EXP NEUROL, V187, P478, DOI 10.1016/j.expneurol.2004.01.030
   Li B, 2000, NAT MED, V6, P1115, DOI 10.1038/80450
   Liu P, 2008, SHOCK, V30, P545, DOI 10.1097/SHK.0b013e31816a192d
   Loehberg CR, 2007, CANCER RES, V67, P12026, DOI 10.1158/0008-5472.CAN-07-3058
   Maclean KH, 2008, J CLIN INVEST, V118, P79, DOI 10.1172/JCI33700
   Mahmoudi M, 2008, CIRC RES, V103, P717, DOI 10.1161/CIRCRESAHA.108.182899
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Matoba S, 2006, SCIENCE, V312, P1650, DOI 10.1126/science.1126863
   Matsuoka S, 2007, SCIENCE, V316, P1160, DOI 10.1126/science.1140321
   Mercer J, 2005, CIRC RES, V96, P667, DOI 10.1161/01.RES.0000161069.15577.ca
   Mercer J, 2006, CELL CYCLE, V5, P1907, DOI 10.4161/cc.5.17.3166
   Merched AJ, 2004, CIRCULATION, V110, P3830, DOI 10.1161/01.CIR.0000148681.01282.89
   Merched AJ, 2003, ARTERIOSCL THROM VAS, V23, P1608, DOI 10.1161/01.ATV.0000084825.88022.53
   Miles PD, 2007, AM J PHYSIOL-ENDOC M, V293, pE70, DOI 10.1152/ajpendo.00259.2006
   Minamino T, 2009, NAT MED, V15, P1082, DOI 10.1038/nm.2014
   Razani B, 2008, ENDOCRIN METAB CLIN, V37, P603, DOI 10.1016/j.ecl.2008.05.001
   Ricci R, 2004, SCIENCE, V306, P1558, DOI 10.1126/science.1101909
   Schneider JG, 2006, CELL METAB, V4, P377, DOI 10.1016/j.cmet.2006.10.002
   Semenkovich CF, 1998, J LIPID RES, V39, P1141
   Su Y, 2000, ANN INTERN MED, V133, P770, DOI 10.7326/0003-4819-133-10-200011210-00009
   Sumara G, 2005, CELL MOL LIFE SCI, V62, P2487, DOI 10.1007/s00018-005-5253-6
   Van Gaal LF, 2006, NATURE, V444, P875, DOI 10.1038/nature05487
   van Vlijmen BJM, 2001, CIRC RES, V88, P780, DOI 10.1161/hh0801.089261
   Vousden KH, 2009, CELL, V137, P413, DOI 10.1016/j.cell.2009.04.037
   Wang J, 2005, CANCER RES, V65, P6601, DOI 10.1158/0008-5472.CAN-04-4184
   Wu DF, 2005, J LIPID RES, V46, P1380, DOI 10.1194/jlr.M400430-JLR200
   Wu GS, 2004, CANCER BIOL THER, V3, P156, DOI 10.4161/cbt.3.2.614
NR 45
TC 26
Z9 26
U1 1
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD JUL
PY 2010
VL 51
IS 7
BP 1738
EP 1746
DI 10.1194/jlr.M003681
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 609BB
UT WOS:000278628700010
PM 20208057
OA Green Published
DA 2025-06-11
ER

PT J
AU Kyalwazi, AN
   Woods-Giscombe, CL
   Johnson, MP
   Jones, C
   Hayes, SN
   Cooper, LA
   Patten, CA
   Brewer, LC
AF Kyalwazi, Ashley N.
   Woods-Giscombe, Cheryl L.
   Johnson, Matthew P.
   Jones, Clarence
   Hayes, Sharonne N.
   Cooper, Lisa A.
   Patten, Christi A.
   Brewer, LaPrincess C.
TI Associations Between the Superwoman Schema, Stress, and Cardiovascular
   Health Among African-American Women
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Article
DE African Americans; Women's health; Stress; Cardiovascular risk factors
ID RISK
AB Background African-American (AA) women are less likely to achieve ideal cardiovascular (CV) health compared with women of other racial/ethnic subgroups, primarily due to structural and psychosocial barriers. A potential psychosocial construct relevant to ideal CV health is the superwoman schema (SWS).Purpose We explored whether the SWS was associated with perceived stress, CV risk factors, and overall CV health among AA women.Methods This cross-sectional analysis of the FAITH! Heart Health+ Study was conducted among AA women with high cardiometabolic risk. Pearson correlation evaluated associations between SWS and CV risk factors (e.g., stress, hypertension, diabetes, etc.). The 35-item SWS questionnaire includes five domains. Stress was measured by the 8-item Global Perceived Stress Scale (GPSS). CV health was assessed using the American Heart Association Life's Simple 7 (LS7) rubric of health behaviors/biometrics. Data acquisition spanned from February to August 2022.Results The 38 women included in the analysis (mean age 54.3 [SD 11.5] years) had a high CV risk factor burden (71.1% hypertension, 76.3% overweight/obesity, 28.9% diabetes, 39.5% hyperlipidemia). Mean GPSS level was 7.7 (SD 5.2), CV health score 6.7 (SD 1.8), and SWS score 60.3 (SD 18.0). Feeling an "obligation to help others" and "obligation to present an image of strength" had strongest correlations with GPSS score among all SWS domains (r = 0.51; p = .002 and r = 0.39; p = .02, respectively). Correlation among the SWS domains and traditional CV risk factors was not statistically significant.Conclusion Our findings suggest that an obligation to help others and to project an image of strength could be contributing to stress among AA women.
   Compared with women of other racial groups, African-American (AA) women in the USA have a higher cardiovascular (CV) disease burden and are at higher risk of maternal mortality from preventable CV health outcomes. The Giscombe Superwoman Schema (SWS) is a framework designed to characterize various aspects of the superwoman role that AA women may adopt to preserve themselves, their families, and their communities amidst the myriad of inequities that can compromise their ability to achieve ideal CV health. In this Brief Report, our team explored whether the SWS was associated with perceived stress, CV risk factors, and overall CV health among AA women. The study participants were AA women with high cardiometabolic risk residing in the Rochester and Minneapolis, St. Paul, Minnesota areas, recruited from the FAITH! Heart Health+ Study. We observed a positive association between the SWS and perceived stress levels, suggesting that the obligation to help others and to project an image of strength could be contributing to overall stress levels among AA women.
C1 [Kyalwazi, Ashley N.] Harvard Med Sch, Boston, MA 02115 USA.
   [Woods-Giscombe, Cheryl L.] Univ North Carolina Chapel Hill, Sch Nursing, Chapel Hill, NC USA.
   [Johnson, Matthew P.] Mayo Clin, Dept Quantitat Hlth Sci, Div Clin Trials & Biostat, Rochester, MN USA.
   [Jones, Clarence] Hue Man Partnership, Minneapolis, MN USA.
   [Hayes, Sharonne N.; Brewer, LaPrincess C.] Mayo Clin, Coll Med, Dept Cardiovasc Med, Rochester, MN USA.
   [Cooper, Lisa A.] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD USA.
   [Patten, Christi A.] Mayo Clin, Coll Med, Dept Psychiat & Psychol, Rochester, MN USA.
   [Brewer, LaPrincess C.] Mayo Clin, Ctr Hlth Equ & Community Engagement Res, Rochester, MN USA.
C3 Harvard University; Harvard Medical School; University of North
   Carolina; University of North Carolina Chapel Hill; University of North
   Carolina School of Medicine; Mayo Clinic; Mayo Clinic; Johns Hopkins
   University; Mayo Clinic; Mayo Clinic
RP Kyalwazi, AN (corresponding author), Harvard Med Sch, Boston, MA 02115 USA.
EM ashley_kyalwazi@hms.harvard.edu; cherylw@email.unc.edu;
   johnson.matthew5@mayo.edu; clarencejones7428@gmail.com;
   hayes.sharonne@mayo.edu; lisa.cooper@jhmi.edu; patten.christi@mayo.edu;
   brewer.laprincess@mayo.edu
RI GISCOMBE, CHERYL/AAG-5815-2020
OI Woods-Giscombe, Cheryl/0000-0001-6245-783X; Cooper,
   Lisa/0000-0001-6707-6390; jones, clarence/0000-0001-9030-2368; Hayes,
   Sharonne/0000-0003-3129-362X; Brewer, LaPrincess/0000-0002-6468-9324
FU National Institutes of Health (NIH)/National Institute on Minority
   Health and Health Disparities (NIMHD) [1 R21 MD013490-01]; National
   Center for Advancing Translational Sciences (NCATS) [UL1 TR000135]; Mayo
   Clinic Center for Health Equity and Community Engagement in Research;
   Mayo Clinic Executive Office; American Heart Association-Amos Medical
   Faculty Development Program [19AMFDP35040005]; NCATS (CTSA) [KL2
   TR002379]; Centers for Disease Control and Prevention (CDC)
   [CDC-DP18-1817]; NIMHD [5R01MD015388]; National Center for Complementary
   and Integrative Health [5T32AT003378]
FX Preliminary findings of this study were presented as an abstract at the
   2023 Society of Behavioral Medicine Annual Meeting and Scientific
   Sessions in Phoenix, Arizona (Cardiovascular Disease Special Interest
   Group Trainee Award). We extend our gratitude to the FAITH! Community
   Steering Committee members, including Courtney Baechler, MD, Allyson
   Brotherson, MD, Tawonda Burks, Wale Elegbede, Princess Titus, Jacqueline
   Johnson, Loralean Jordan, Sandra Means, Stanton Shanedling, PhD, Sueling
   Schardin, Samuel Simmons, and Pastor Johnnie B. Williams, for their
   valuable input and support of this study. We also appreciate all study
   participants for their commitment to diversity in research and clinical
   trials. The research reported herein was supported by the National
   Institutes of Health (NIH)/National Institute on Minority Health and
   Health Disparities (NIMHD) (grant 1 R21 MD013490-01), the Clinical and
   Translational Science Awards (CTSA) (grant UL1 TR000135) from the
   National Center for Advancing Translational Sciences (NCATS) to Mayo
   Clinic, the Mayo Clinic Center for Health Equity and Community
   Engagement in Research and the Mayo Clinic Executive Office. Dr. Brewer
   was supported by the American Heart Association-Amos Medical Faculty
   Development Program (grant 19AMFDP35040005), NCATS (CTSA grant KL2
   TR002379) and the Centers for Disease Control and Prevention (CDC, grant
   CDC-DP18-1817) during the implementation of this work. Dr.
   Woods-Giscombe was supported by the NIMHD (grant 5R01MD015388) and the
   National Center for Complementary and Integrative Health (grant
   5T32AT003378). Its contents are solely the responsibility of the authors
   and do not necessarily represent the official views of NCATS, NIH, or
   CDC. The funding bodies had no role in the study design; in the
   collection, analysis, and interpretation of data; writing of the
   manuscript; and in the decision to submit the manuscript for
   publication.
CR Albert MA, 2013, CURR CARDIOVASC RISK, V7, DOI 10.1007/s12170-013-0338-5
   Allen AM, 2019, ANN NY ACAD SCI, V1457, P104, DOI 10.1111/nyas.14188
   Brewer LC, 2022, CIRCULATION, V146, P175, DOI 10.1161/CIRCULATIONAHA.122.059046
   Bromfield SG, 2020, ANN BEHAV MED, V54, P761, DOI 10.1093/abm/kaaa015
   Carvalho K, 2022, MATERN CHILD HLTH J, V26, P764, DOI 10.1007/s10995-021-03181-9
   Center for American Progress, WOMEN COLOR WAGE GAP
   Chinn JJ, 2021, J WOMENS HEALTH, V30, P212, DOI 10.1089/jwh.2020.8868
   Cyriac J, 2021, JMIR MHEALTH UHEALTH, V9, DOI 10.2196/28024
   Hasbani NR, 2022, CIRCULATION, V145, P808, DOI 10.1161/CIRCULATIONAHA.121.053730
   Howell EA, 2018, CLIN OBSTET GYNECOL, V61, P387, DOI 10.1097/GRF.0000000000000349
   Kalinowski J, 2019, CIRCULATION, V139, P1003, DOI 10.1161/CIRCULATIONAHA.118.037689
   Kyalwazi AN, 2022, CIRCULATION, V146, P211, DOI 10.1161/CIRCULATIONAHA.122.060199
   Lalika M, 2024, CONTEMP CLIN TRIALS, V143, DOI 10.1016/j.cct.2024.107600
   Lewis TT, 2023, HEALTH PSYCHOL, V42, P485, DOI 10.1037/hea0001309
   Sheffield-Abdullah KM, 2021, ARCH PSYCHIAT NURS, V35, P88, DOI 10.1016/j.apnu.2020.09.011
   Thomas MD, 2022, GERONTOLOGIST, V62, P762, DOI 10.1093/geront/gnac005
   U.S. Department of Labor Blog, CONNECTING DOTS WOME
   West S, 2021, J SOC SOC WORK RES, V12, P263, DOI 10.1086/714544
   Woods-Giscombe CL, 2019, ISSUES MENT HEALTH N, V40, P672, DOI 10.1080/01612840.2019.1584654
   Woods-Giscombé CL, 2010, QUAL HEALTH RES, V20, P668, DOI 10.1177/1049732310361892
NR 20
TC 1
Z9 1
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD AUG 31
PY 2024
VL 58
IS 12
BP 863
EP 868
DI 10.1093/abm/kaae047
EA AUG 2024
PG 6
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA M1Y4G
UT WOS:001303492000001
PM 39216076
DA 2025-06-11
ER

PT J
AU Kobori, M
   Masumoto, S
   Akimoto, Y
   Oike, H
AF Kobori, Masuko
   Masumoto, Saeko
   Akimoto, Yukari
   Oike, Hideaki
TI Chronic dietary intake of quercetin alleviates hepatic fat accumulation
   associated with consumption of a Western-style diet in C57/BL6J mice
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Liver steatosis; Metabolic disorder; Oxidative stress; Quercetin;
   Western diet
ID ACTIVATED PROTEIN-KINASE; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; GENE-EXPRESSION; IN-VIVO;
   LIVER; OBESITY; STEATOSIS
AB Scope: To determine the effect of consumption of a quercetin-rich diet on obesity and dysregulated hepatic gene expression.
   Methods and results: C56BL/6J mice were fed for 20wk on AIN93G (control) or a Western diet high in fat, cholesterol and sucrose, both with or without 0.05% quercetin. Triglyceride levels in plasma, thiobarbituric acid-reactive substances (oxidative stress marker) and glutathione levels and peroxisome proliferator-activated receptor alpha expression in livers of mice fed with the Western diet were all improved after 8wk feeding with quercetin. After 20 wk, further reductions of visceral and liver fat accumulation and improved hyperglycemia, hyperinsulinemia, dyslipidemia and plasma adiponectin and TNF alpha levels in these mice fed with quercetin were observed. The expression of hepatic genes related to steatosis, such as peroxisome proliferator-activated receptor gamma and sterol regulatory element-binding protein-1c was also normalized by quercetin. In mice fed with the control diet, quercetin did not affect body weight but reduces the plasma TNF alpha and hepatic thiobarbituric acid-reactive substance levels.
   Conclusion: In mice fed with a Western diet, chronic dietary intake of quercetin reduces liver fat accumulation and improves systemic parameters related to metabolic syndrome, probably mainly through decreasing oxidative stress and reducing PPAR alpha expression, and the subsequent reduced expression in the liver of genes related to steatosis.
C1 [Kobori, Masuko; Masumoto, Saeko; Akimoto, Yukari; Oike, Hideaki] Natl Agr & Food Res Org, Natl Food Res Inst, Tsukuba, Ibaraki 3058642, Japan.
C3 National Food Research Institute - Japan; National Agriculture & Food
   Research Organization - Japan
RP Kobori, M (corresponding author), Natl Agr & Food Res Org, Natl Food Res Inst, 2-1-12 Kannondai, Tsukuba, Ibaraki 3058642, Japan.
EM kobori@affrc.go.jp
RI Oike, Hideaki/C-6457-2009
OI Masumoto, Saeko/0000-0003-3174-9738; Oike, Hideaki/0000-0002-6139-5726
FU Ministry of Agriculture, Forestry and Fisheries (MAFF)
FX This work was supported in part by a grant from the Ministry of
   Agriculture, Forestry and Fisheries (MAFF) Food Research Project
   'Development of evaluation and management methods for supply of reliable
   and functional food and farm produce'.
CR Ahn J, 2008, BIOCHEM BIOPH RES CO, V373, P545, DOI 10.1016/j.bbrc.2008.06.077
   Aragno M, 2009, FREE RADICAL BIO MED, V47, P1067, DOI 10.1016/j.freeradbiomed.2009.07.016
   Arts ICW, 2005, AM J CLIN NUTR, V81, p317S, DOI 10.1093/ajcn/81.1.317S
   Boden-Albala B, 2009, NEUROEPIDEMIOLOGY, V32, P296, DOI 10.1159/000204914
   Browning JD, 2004, J CLIN INVEST, V114, P147, DOI 10.1172/JCI200422422
   Buettner R, 2007, OBESITY, V15, P798, DOI 10.1038/oby.2007.608
   Capeau J, 2008, DIABETES METAB, V34, P649, DOI 10.1016/S1262-3636(08)74600-7
   Conseil G, 1998, P NATL ACAD SCI USA, V95, P9831, DOI 10.1073/pnas.95.17.9831
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   de Boer VCJ, 2005, J NUTR, V135, P1718, DOI 10.1093/jn/135.7.1718
   Dufour C, 2007, BBA-GEN SUBJECTS, V1770, P958, DOI 10.1016/j.bbagen.2007.02.005
   Eid HM, 2010, MOL NUTR FOOD RES, V54, P991, DOI 10.1002/mnfr.200900218
   Feillet-Coudray C, 2009, FREE RADICAL BIO MED, V46, P624, DOI 10.1016/j.freeradbiomed.2008.11.020
   Fujita K, 2006, CIRC J, V70, P1437, DOI 10.1253/circj.70.1437
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gómez-Valadés AG, 2008, DIABETES, V57, P2199, DOI 10.2337/db07-1087
   Grassi D, 2008, J NUTR, V138, P1554
   Harwood M, 2007, FOOD CHEM TOXICOL, V45, P2179, DOI 10.1016/j.fct.2007.05.015
   Heidemann C, 2008, CIRCULATION, V118, P230, DOI 10.1161/CIRCULATIONAHA.108.771881
   HOSOKAWA N, 1992, MOL CELL BIOL, V12, P3490, DOI 10.1128/MCB.12.8.3490
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Howitz KT, 2003, NATURE, V425, P191, DOI 10.1038/nature01960
   Inoue M, 2005, BIOCHEM BIOPH RES CO, V336, P215, DOI 10.1016/j.bbrc.2005.08.070
   Kadowaki T, 2005, ENDOCR REV, V26, P439, DOI 10.1210/er.2005-0005
   Kadowaki T, 2006, J CLIN INVEST, V116, P1784, DOI 10.1172/JCI29126
   Kersten S, 2000, NATURE, V405, P421, DOI 10.1038/35013000
   Knopp RH, 1999, NEW ENGL J MED, V341, P498, DOI 10.1056/NEJM199908123410707
   Kobori M, 2009, MOL NUTR FOOD RES, V53, P859, DOI 10.1002/mnfr.200800310
   Kumashiro N, 2008, DIABETES, V57, P2083, DOI 10.2337/db08-0144
   Le Marchand-Brustel Y, 2003, BIOCHEM SOC T, V31, P1152
   Lin CC, 2008, BRIT J NUTR, V99, P37, DOI 10.1017/S0007114507793881
   Mantena SK, 2008, FREE RADICAL BIO MED, V44, P1259, DOI 10.1016/j.freeradbiomed.2007.12.029
   Meyers KJ, 2008, J AGR FOOD CHEM, V56, P830, DOI 10.1021/jf072358l
   Milagro FI, 2006, OBESITY, V14, P1118, DOI 10.1038/oby.2006.128
   Mink PJ, 2007, AM J CLIN NUTR, V85, P895, DOI 10.1093/ajcn/85.3.895
   Osada K, 2006, LIPIDS, V41, P133, DOI 10.1007/s11745-006-5081-y
   Pereira MA, 2009, INT J ENV RES PUB HE, V6, P2568, DOI 10.3390/ijerph6102568
   Pérez-Carreras M, 2003, HEPATOLOGY, V38, P999, DOI 10.1053/jhep.2003.50398
   Polyzos SA, 2010, DIABETES OBES METAB, V12, P365, DOI 10.1111/j.1463-1326.2009.01176.x
   Radonjic M, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006646
   Rivera L, 2008, OBESITY, V16, P2081, DOI 10.1038/oby.2008.315
   Sekiya M, 2008, BIOCHEM BIOPH RES CO, V375, P602, DOI 10.1016/j.bbrc.2008.08.068
   Shibasaki M, 2002, DIABETOLOGIA, V45, P518, DOI 10.1007/s00125-002-0786-9
   Stewart LK, 2009, DIABETOLOGIA, V52, P514, DOI 10.1007/s00125-008-1252-0
   van Baak MA, 2009, OBES REV, V10, P9, DOI 10.1111/j.1467-789X.2008.00561.x
   van Dam RM, 2002, ANN INTERN MED, V136, P201, DOI 10.7326/0003-4819-136-3-200202050-00008
   van Meeuwen JA, 2007, TOXICOL APPL PHARM, V221, P372, DOI 10.1016/j.taap.2007.03.016
   Yu ST, 2003, J BIOL CHEM, V278, P498, DOI 10.1074/jbc.M210062200
   Zang MW, 2006, DIABETES, V55, P2180, DOI 10.2337/db05-1188
NR 50
TC 202
Z9 224
U1 0
U2 61
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD APR
PY 2011
VL 55
IS 4
BP 530
EP 540
DI 10.1002/mnfr.201000392
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 748TV
UT WOS:000289416100003
PM 21462320
DA 2025-06-11
ER

PT J
AU Feillet-Coudray, C
   Fouret, G
   Vigor, C
   Bonafos, B
   Jover, B
   Blachnio-Zabielska, A
   Rieusset, J
   Casas, F
   Gaillet, S
   Landrier, JF
   Durand, T
   Coudray, C
AF Feillet-Coudray, Christine
   Fouret, Gilles
   Vigor, Claire
   Bonafos, Beatrice
   Jover, Bernard
   Blachnio-Zabielska, Agnieszka
   Rieusset, Jennifer
   Casas, Francois
   Gaillet, Sylvie
   Landrier, Jean Francois
   Durand, Thierry
   Coudray, Charles
TI Long-Term Measures of Dyslipidemia, Inflammation, and Oxidative Stress
   in Rats Fed a High-Fat/High-Fructose Diet
SO LIPIDS
LA English
DT Article
DE Glucose intolerance; Hepatic steatosis; High-fat diet; Inflammation;
   Isoprostanoids; Lipids; Metabolic syndrome; Obesity; Oxidative stress;
   Rat
ID HIGH-FAT DIET; METABOLIC SYNDROME; LIVER-DISEASE; INSULIN-RESISTANCE;
   ADIPOSE-TISSUE; NADPH OXIDASES; NOX FAMILY; OBESITY; ASSAY; ISOPROSTANES
AB Inflammation and oxidative stress are thought to be involved in, or associated with, the development of obesity, dyslipidemia, hepatic steatosis, and insulin resistance. This work was designed to determine the evolution of inflammation and oxidative stress during onset and progression of hepatic steatosis and glucose intolerance. Seventy-five male Wistar rats were divided to control and high-fat high-fructose (HFHFr) groups. A subgroup of each group was sacrificed at 4, 8, 12, 16, and 20 weeks. HFHFr-fed rats exhibited overweight, glucose intolerance, and hepatic steatosis with increased contents of hepatic diacylglycerols and ceramides. The HFHFr diet increased hepatic interleukin 6 (IL-6) protein and adipose tissue CCL5 gene expression and hepatic nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity but not mitochondrial reactive oxygen species (ROS) production. The HFHFr diet decreased plasma and liver levels of isoprostanoid metabolites as well as plasma thiobarbituric acid-reactive substance (TBARS) levels. Hepatic glutathione content was decreased with a moderate decrease in superoxide dismutase (SOD) and glutathione peroxidase (GPx) with the HFHFr diet. Overall, HFHFr diet led to hepatic lipid accumulation and glucose intolerance, which were accompanied by only moderate inflammation and oxidative stress. Most of these changes occurred at the same time and as early as 8 or 12 weeks of diet treatment. This implies that oxidative stress may be the result, not the cause, of these metabolic alterations, and suggests that marked hepatic oxidative stress should probably occur at the end of the steatotic stage to result in frank insulin resistance and steatohepatitis. These findings need to be further evaluated in other animal species as well as in human studies.
C1 [Feillet-Coudray, Christine; Fouret, Gilles; Bonafos, Beatrice; Casas, Francois; Gaillet, Sylvie; Coudray, Charles] Univ Montpellier, INRA, DMEM Dynam Musculaire & Metab, 2 Pl Viala, F-34060 Montpellier, France.
   [Vigor, Claire; Durand, Thierry] Univ Montpellier, IBMM, CNRS, ENSCM, 15 Ave Charles Flahault, F-34090 Montpellier, France.
   [Jover, Bernard] Univ Montpellier, INSERM, CNRS, PhyMedExp, 371 Ave Doyen Gaston Giraud, F-34295 Montpellier, France.
   [Blachnio-Zabielska, Agnieszka] Med Univ Bialystok, Dept Physiol, Jana Kilinskiego 1, PL-15089 Bialystok, Poland.
   [Blachnio-Zabielska, Agnieszka] Med Univ Bialystok, Epidemiol & Metab Disorders Dept, Jana Kilinskiego 1, PL-15089 Bialystok, Poland.
   [Rieusset, Jennifer] Fac Med Lyon Sud, INSERM, UMR U1060, 165 Chemin Grand Revoyet, F-69921 Oullins, France.
   [Landrier, Jean Francois] Aix Marseille Univ, INSERM, INRA, C2VN, 27 Blvd Jean Moulin, F-13385 Marseille, France.
C3 Universite de Montpellier; INRAE; Ecole nationale superieure de chimie
   de Montpellier; Centre National de la Recherche Scientifique (CNRS);
   Universite de Montpellier; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite de Montpellier; Centre National
   de la Recherche Scientifique (CNRS); Medical University of Bialystok;
   Medical University of Bialystok; Universite Claude Bernard Lyon 1;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Aix-Marseille Universite; Institut National de la Sante et de la
   Recherche Medicale (Inserm); INRAE
RP Coudray, C (corresponding author), Univ Montpellier, INRA, DMEM Dynam Musculaire & Metab, 2 Pl Viala, F-34060 Montpellier, France.
EM charles.coudray@inra.fr
RI COUDRAY, Charles/AGG-4757-2022; Blachnio-Zabielsk,
   Agnieszka/A-4879-2018; Rieusset, Jennifer/F-1595-2018; Landrier,
   Jean-Francois/AAH-2757-2019
OI Lab, Carmen/0000-0002-5935-3236; JOVER, Bernard/0000-0001-5826-5755;
   Rieusset, Jennifer/0000-0002-1587-2253; VIGOR,
   Claire/0000-0002-1569-0425; Carmen, Team2/0000-0001-9867-5724; Landrier,
   Jean-Francois/0000-0002-8690-8014; Blachnio-Zabielska,
   Agnieszka/0000-0002-8055-0576; Francois, Casas/0000-0002-5535-8195
CR Anderson EJ, 2009, J CLIN INVEST, V119, P573, DOI 10.1172/JCI37048
   Ando K, 2009, FREE RADICAL BIO MED, V47, P213, DOI 10.1016/j.freeradbiomed.2009.04.030
   Anvari E, 2015, FREE RADICAL RES, V49, P1308, DOI 10.3109/10715762.2015.1067697
   Aoun M, 2012, BRIT J NUTR, V107, P647, DOI 10.1017/S000711451100331X
   Asrih M, 2013, J ENDOCRINOL, V218, pR25, DOI 10.1530/JOE-13-0201
   Barja G, 2002, J BIOENERG BIOMEMBR, V34, P227, DOI 10.1023/A:1016039604958
   Bedard K, 2007, PHYSIOL REV, V87, P245, DOI 10.1152/physrev.00044.2005
   BEERS RF, 1952, J BIOL CHEM, V195, P133
   Blachnio-Zabielska AU, 2013, J LIPID RES, V54, P1705, DOI 10.1194/jlr.D035006
   Blachnio-Zabielska AU, 2012, RAPID COMMUN MASS SP, V26, P1134, DOI 10.1002/rcm.6216
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Brandes RP, 2014, FREE RADICAL BIO MED, V76, P208, DOI 10.1016/j.freeradbiomed.2014.07.046
   Bravard A, 2011, AM J PHYSIOL-ENDOC M, V300, pE581, DOI 10.1152/ajpendo.00455.2010
   Cardoso AR, 2010, J BIOENERG BIOMEMBR, V42, P245, DOI 10.1007/s10863-010-9284-9
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   Dupuy A, 2016, ANAL CHIM ACTA, V921, P46, DOI 10.1016/j.aca.2016.03.024
   Feillet-Coudray C, 2009, FREE RADICAL BIO MED, V46, P624, DOI 10.1016/j.freeradbiomed.2008.11.020
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Finck BN, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/104132
   FLOHE L, 1984, METHOD ENZYMOL, V105, P114
   Fouret G, 2018, BRIT J NUTR, V119, P368, DOI [10.1017/S0007114517003713, 10.1017/s0007114517003713]
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Galano JM, 2017, PROG LIPID RES, V68, P83, DOI 10.1016/j.plipres.2017.09.004
   Gerner RR, 2013, CAN J PHYSIOL PHARM, V91, P867, DOI 10.1139/cjpp-2013-0050
   GRIFFITH OW, 1980, ANAL BIOCHEM, V106, P207, DOI 10.1016/0003-2697(80)90139-6
   JOCELYN PC, 1987, METHOD ENZYMOL, V143, P44
   Johnson RJ, 2013, OBESITY, V21, P659, DOI 10.1002/oby.20026
   Kawano Y, 2013, J GASTROENTEROL, V48, P434, DOI 10.1007/s00535-013-0758-5
   Li S, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/4234061
   Mantena SK, 2008, FREE RADICAL BIO MED, V44, P1259, DOI 10.1016/j.freeradbiomed.2007.12.029
   MARKLUND S, 1976, J BIOL CHEM, V251, P7504
   Nakamura A, 2013, INT J MOL SCI, V14, P21240, DOI 10.3390/ijms141121240
   Paik Yong Han, 2011, Korean J Hepatol, V17, P251, DOI 10.3350/kjhep.2011.17.4.251
   Peng YH, 2012, SURG OBES RELAT DIS, V8, P73, DOI 10.1016/j.soard.2011.07.019
   Penumetcha M, 2012, ATHEROSCLEROSIS, V220, P53, DOI 10.1016/j.atherosclerosis.2011.10.001
   Perry RJ, 2014, NATURE, V510, P84, DOI 10.1038/nature13478
   Petersen MC, 2017, TRENDS PHARMACOL SCI, V38, P649, DOI 10.1016/j.tips.2017.04.004
   Petersson H, 2010, BRIT J NUTR, V104, P1357, DOI 10.1017/S000711451000228X
   Renaud HJ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0088584
   Roberts CK, 2006, METABOLISM, V55, P928, DOI 10.1016/j.metabol.2006.02.022
   SUNDERMAN FW, 1985, ANN CLIN LAB SCI, V15, P229
   Tilg H, 2010, HEPATOLOGY, V52, P1836, DOI 10.1002/hep.24001
   Tordjman J, 2008, DIABETES METAB, V34, P658, DOI 10.1016/S1262-3636(08)74601-9
   Ucar F, 2013, REDOX REP, V18, P127, DOI 10.1179/1351000213Y.0000000050
   Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
   Vial G, 2011, J HEPATOL, V54, P348, DOI 10.1016/j.jhep.2010.06.044
   Witko-Sarsat V, 1998, J IMMUNOL, V161, P2524
   YAGI K, 1984, METHOD ENZYMOL, V105, P328
   Yang ZR, 2016, BMC PHARMACOL TOXICO, V17, DOI 10.1186/s40360-016-0059-8
   Yin HY, 2008, BIOFACTORS, V34, P109, DOI 10.1002/biof.5520340203
   Zhu MJ, 2008, WORLD J GASTROENTERO, V14, P4677, DOI 10.3748/wjg.14.4677
   Zivkovic AM, 2007, AM J CLIN NUTR, V86, P285, DOI 10.1093/ajcn/86.2.285
NR 52
TC 40
Z9 44
U1 2
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0024-4201
EI 1558-9307
J9 LIPIDS
JI Lipids
PD JAN
PY 2019
VL 54
IS 1
BP 81
EP 97
DI 10.1002/lipd.12128
PG 17
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA HL7ZT
UT WOS:000458961300009
PM 30767221
OA Green Published
DA 2025-06-11
ER

PT J
AU Sankhla, M
   Sharma, TK
   Mathur, K
   Rathor, JS
   Butolia, V
   Gadhok, AK
   Vardey, SK
   Sinha, M
   Kaushik, GG
AF Sankhla, Manisha
   Sharma, Tarun Kumar
   Mathur, Keerti
   Rathor, Jai Singh
   Butolia, Varsha
   Gadhok, Amita K.
   Vardey, Satish Kumar
   Sinha, Maheep
   Kaushik, G. G.
TI Relationship of Oxidative Stress with Obesity and its Role in Obesity
   Induced Metabolic Syndrome
SO CLINICAL LABORATORY
LA English
DT Article
DE Obesity; abdominal adiposity; oxidative stress; adiponectin
ID DENSITY-LIPOPROTEIN CHOLESTEROL; ADIPONECTIN; INFLAMMATION; GLUCOSE;
   PLASMA; RISK; MEN
AB Background: Individuals with obesity and abdominal adiposity are at higher risk for hypeinsulinaemia, insulin resistance, and diabetes. This study was therefore designed to investigate the relationship of obesity with oxidative stress and the role of abdominal adiposity on obesity induced oxidative stress, and further to explore the possible mechanism of obesity associated metabolic syndrome.
   Methods: A total of 150 subjects (120 men and 30 women), aged 17-26 years of both genders, were studied. Body Mass Index and Waist-to-Hip Ratio were taken as a measure of generalized obesity and abdominal adiposity. The biochemical tests done included fasting blood glucose (FBG), lipid profile parameters, serum malondialdehyde (as a biomarker of oxidative stress), and serum adiponectin.
   Results: The concentration of serum malondialdehyde (MDA) increased with increasing levels of BMI (as per the NW classification), which was found to be non-significant statistically in overweight subjects while obese class-I and class-II subjects exhibited a statistically significant (p<0.001) higher level of serum malondialdehyde as compared to normal-weight subjects. Furthermore, according to the present study groups, on comparison with normal-weight subjects (Group-I), obese subjects with abdominal adiposity (Class-2) had statistically significant (p<0.001) higher serum concentration of malondialdehyde while a non-significant difference was observed in obese subjects without abdominal adiposity (Class-1). Even within the subset of obese subjects, a statistically significant (p<0.001) difference was depicted, suggesting the role of abdominal adiposity. Karl Pearson coefficient of correlation revealed a statistically significant negative correlation of malondialdehyde with adiponectin (r = - 0.587; p<0.001).
   Conclusions: Obese subjects exhibit increased systemic oxidative stress, which is enhanced when obesity is associated with abdominal adiposity and, moreover, increased oxidative stress is associated with adiponectin deficiency. (Clin. Lab. 2012;58:385-392)
C1 [Sharma, Tarun Kumar] Univ Hlth Sci, Dept Biochem, Pt BD Sharma, PGIMS, Rohtak 124001, Haryana, India.
   [Sankhla, Manisha; Mathur, Keerti] SMS Med Coll & Hosp, Dept Physiol, Jaipur, Rajasthan, India.
   [Rathor, Jai Singh] Fortis Escorts Hosp, Jaipur, Rajasthan, India.
   [Butolia, Varsha] Jhalawar Med Coll, Dept Physiol, Jhalawar, Rajasthan, India.
   [Gadhok, Amita K.] Rama Med Coll & Hosp, Dept Biochem, Ghaziabad, UP, India.
   [Vardey, Satish Kumar; Sinha, Maheep] SMS Med Coll & Hosp, Dept Biochem, Jaipur, Rajasthan, India.
   [Kaushik, G. G.] JLN Med Coll, Dept Biochem, Ajmer, Rajasthan, India.
C3 Pt. B.D. Sharma Post Graduate Institute of Medical Sciences (PGIMS),
   Rohtak; SMS Medical College & Hospital; Fortis Escorts Hospital; Rama
   University; SMS Medical College & Hospital
RP Sharma, TK (corresponding author), Univ Hlth Sci, Dept Biochem, Pt BD Sharma, PGIMS, Rohtak 124001, Haryana, India.
EM sharma_bio82@yahoo.co.in
CR ALLAIN CC, 1974, CLIN CHEM, V20, P470
   [Anonymous], 2008, WHO REPORT 2008 WAIS
   ASSMANN G, 1983, CLIN CHEM, V29, P2026
   Block G, 2002, AM J EPIDEMIOL, V156, P274, DOI 10.1093/aje/kwf029
   BUCOLO G, 1973, CLIN CHEM, V19, P476
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Davì G, 2002, JAMA-J AM MED ASSOC, V288, P2008, DOI 10.1001/jama.288.16.2008
   Deletes R, OXFORD TXB PUBLIC HL, V1, P170
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Kahn BB, 2000, J CLIN INVEST, V106, P473, DOI 10.1172/JCI10842
   Kamigaki M, 2006, BIOCHEM BIOPH RES CO, V339, P624, DOI 10.1016/j.bbrc.2005.11.059
   Katsuki A, 2006, DIABETES RES CLIN PR, V73, P310, DOI 10.1016/j.diabres.2006.02.014
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Montagne CT, 2000, DIABETES, V49, P883, DOI 10.2337/diabetes.49.6.883
   Nandeesha Hanumanthappa, 2008, Indian J Physiol Pharmacol, V52, P205
   Olusi SO, 2002, INT J OBESITY, V26, P1159, DOI 10.1038/sj.ijo.0802066
   Patel DA, 2006, METABOLISM, V55, P1551, DOI 10.1016/j.metabol.2006.06.028
   Perticone F, 2001, DIABETES, V50, P159, DOI 10.2337/diabetes.50.1.159
   Pi-Sunyer FX, 1998, OBES RES, V6, p51S
   Saltiel AR, 2001, NATURE, V414, P799, DOI 10.1038/414799a
   SATOH K, 1978, CLIN CHIM ACTA, V90, P37
   Silvio E I, 2010, DIABETES CARE, V33, pS62
   Soares AF, 2005, FREE RADICAL BIO MED, V38, P882, DOI 10.1016/j.freeradbiomed.2004.12.010
   Spiegelman BM, 2001, CELL, V104, P531, DOI 10.1016/S0092-8674(01)00240-9
   Trinder P., 1969, Journal of Clinical Pathology, V22, P158, DOI 10.1136/jcp.22.2.158
   Urakawa H, 2003, J CLIN ENDOCR METAB, V88, P4673, DOI 10.1210/jc.2003-030202
   Van Guilder GP, 2006, OBESITY, V14, P2127, DOI 10.1038/oby.2006.248
   Weinbrenner T, 2006, AM J CLIN NUTR, V83, P30
   Williams IL, 2002, INT J OBESITY, V26, P754, DOI 10.1038/sj.ijo.0801995
   Zhu YG, 2006, BIOMED ENVIRON SCI, V19, P353
   Zimmet P, 2001, NATURE, V414, P782, DOI 10.1038/414782a
NR 32
TC 107
Z9 116
U1 0
U2 8
PU CLIN LAB PUBL
PI HEIDELBERG
PA IM BREITSPIEL 15, HEIDELBERG, D-69126, GERMANY
SN 1433-6510
J9 CLIN LAB
JI Clin. Lab.
PY 2012
VL 58
IS 5-6
BP 385
EP 392
PG 8
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 964QF
UT WOS:000305711100002
PM 22783566
DA 2025-06-11
ER

PT J
AU Kim, YH
   Kim, SM
   Kim, JJ
   Cho, IS
   Jeon, MJ
AF Kim, Yun Hwan
   Kim, Sun Mie
   Kim, Jin Ju
   Cho, In Seong
   Jeon, Myung Jae
TI Does Metabolic Syndrome Impair Sexual Function in Middle- to Old-Aged
   Women?
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE Metabolic Syndrome; Female Sexual Function; FSFI
ID INDEX FSFI; DYSFUNCTION; PREVALENCE; KOREA
AB Introduction.
   To date, there are few studies dealing with the impact of metabolic syndrome (MS) on female sexual function, and the association between MS and female sexual dysfunction (FSD) in middle- to old-aged women remains unclear.
   Aim.
   To evaluate the impact of MS on sexual function in middle- to old-aged women.
   Methods.
   From May 2009 to January 2010, we performed a cross-sectional study of sexually active women (>= 40 years old) who visited a health-screening clinic. Comprehensive history taking, anthropometric measurement, laboratory testing, and questionnaire administration were performed for each of the total 773 women enrolled.
   Main Outcome Measures.
   The Female Sexual Function Index (FSFI) was used to assess the key dimensions of female sexual function.
   Results.
   The median age of enrolled subjects was 48 (40-65) years, and the rates of MS and FSD were 12.2% (94/773) and 54.7% (423/773), respectively. We found that the demographics of women with and without MS (P < 0.05) differed significantly from one another in terms of age, menopausal status, body mass index, educational status, household income, and urinary incontinence (UI) symptoms, although their frequency of FSD was similar (52.1% vs. 55.1%). After adjusting clinical confounders, we found that only the pain domain score was significantly different between women with MS and without MS, while the total FSFI score and other constituent domain scores showed little difference between the two groups. However, in the multivariate logistic regression model, MS and most of its components were not associated with FSD; only age, menopausal status, smoking, depression, and symptomatic UI proved to be independent risk factors for FSD (P < 0.05).
   Conclusions.
   Our study suggests that MS may have little impact on sexual function in middle- to old-aged women. Further studies with population-based and longitudinal design should be conducted to confirm this finding. Kim YH, Kim SM, Kim JJ, Cho IS, and Jeon MJ. Does metabolic syndrome impair sexual function in middle- to old-aged women? J Sex Med 2011;8:1123-1130.
C1 [Jeon, Myung Jae] Seoul Natl Univ, Coll Med, Dept Obstet & Gynecol, Seoul 110744, South Korea.
   [Kim, Yun Hwan] Ewha Womans Univ, Dept Obstet & Gynecol, Sch Med, Seoul, South Korea.
   [Kim, Yun Hwan] Ewha Womans Univ, Med Res Inst, Sch Med, Seoul, South Korea.
   [Kim, Sun Mie; Kim, Jin Ju] Seoul Natl Univ Hosp Hlth Care Syst, Dept Obstet & Gynecol, GangNam Ctr, Seoul, South Korea.
   [Cho, In Seong] Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul 110744, South Korea.
C3 Seoul National University (SNU); Ewha Womans University; Ewha Womans
   University; Seoul National University (SNU); Seoul National University
   Hospital; Seoul National University (SNU)
RP Jeon, MJ (corresponding author), Seoul Natl Univ, Coll Med, Dept Obstet & Gynecol, 28 Yongon Dong, Seoul 110744, South Korea.
EM jeonmj@snu.ac.kr
RI Jeon, Myung/O-2486-2019; Kim, Jin/C-4294-2013; Kim, Kwang
   Pyo/AAG-1815-2020
OI Kim, Yun Hwan/0000-0001-9498-2938; Jeon, Myung Jae/0000-0001-5582-1488
CR Addis IB, 2006, OBSTET GYNECOL, V107, P755, DOI 10.1097/01.AOG.0000202398.27428.e2
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Barber MD, 2006, AM J OBSTET GYNECOL, V195, P942, DOI 10.1016/j.ajog.2006.02.050
   Borges R, 2009, J SEX MED, V6, P2958, DOI 10.1111/j.1743-6109.2009.01412.x
   Chedraui P, 2009, CLIMACTERIC, V12, P213, DOI 10.1080/13697130802607727
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Corona G, 2009, INT J ANDROL, V32, P587, DOI 10.1111/j.1365-2605.2008.00951.x
   Doumas M, 2006, J HYPERTENS, V24, P2387, DOI 10.1097/01.hjh.0000251898.40002.5b
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Esposito K, 2005, INT J IMPOT RES, V17, P224, DOI 10.1038/sj.ijir.3901310
   Esposito K, 2010, INT J IMPOT RES, V22, P179, DOI 10.1038/ijir.2010.6
   Esposito K, 2009, J SEX MED, V6, P1696, DOI 10.1111/j.1743-6109.2009.01284.x
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   Fourcroy J, 1998, INT J IMPOT RES, V10, pS98
   Giugliano F, 2010, J SEX MED, V7, P1883, DOI 10.1111/j.1743-6109.2010.01714.x
   Goldstein I, 1998, INT J IMPOT RES, V10, pS84
   Hara K, 2006, DIABETES CARE, V29, P1123, DOI 10.2337/dc05-2540
   Jackson G, 2010, J SEX MED, V7, P1608, DOI 10.1111/j.1743-6109.2010.01779.x
   Jiann BP, 2009, J SEX MED, V6, P3364, DOI 10.1111/j.1743-6109.2009.01494.x
   KIM H, 2002, KOREAN J ANDROL, V30, P50
   Koca O, 2010, J SEX MED, V7, P3997, DOI 10.1111/j.1743-6109.2010.01932.x
   Laumann EO, 1999, JAMA-J AM MED ASSOC, V281, P537, DOI 10.1001/jama.281.6.537
   Moreira ED, 2006, J SEX MED, V3, P201, DOI 10.1111/j.1743-6109.2006.00210.x
   Park HS, 2007, DIABETES OBES METAB, V9, P50, DOI 10.1111/j.1463-1326.2005.00569.x
   Ponholzer A, 2008, INT J IMPOT RES, V20, P100, DOI 10.1038/sj.ijir.3901605
   Rosen R, 2000, J SEX MARITAL THER, V26, P191, DOI 10.1080/009262300278597
   SHIN MS, 1993, KOREAN J CLIN PSYCHO, V11, P1271
   Traish AM, 2009, J ANDROL, V30, P10, DOI 10.2164/jandrol.108.005215
   Wiegel M, 2005, J SEX MARITAL THER, V31, P1, DOI 10.1080/00926230590475206
   Yaylali GF, 2010, INT J IMPOT RES, V22, P220, DOI 10.1038/ijir.2010.7
NR 30
TC 31
Z9 34
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD APR
PY 2011
VL 8
IS 4
BP 1123
EP 1130
DI 10.1111/j.1743-6109.2010.02174.x
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 744SS
UT WOS:000289115400019
PM 21235723
DA 2025-06-11
ER

PT J
AU Di Majo, D
   Ricciardi, N
   Moncada, A
   Allegra, M
   Frinchi, M
   Di Liberto, V
   Pitonzo, R
   Rappa, F
   Saiano, F
   Vetrano, F
   Miceli, A
   Giglia, G
   Ferraro, G
   Sardo, P
   Gambino, G
AF Di Majo, Danila
   Ricciardi, Nicolo
   Moncada, Alessandra
   Allegra, Mario
   Frinchi, Monica
   Di Liberto, Valentina
   Pitonzo, Rosa
   Rappa, Francesca
   Saiano, Filippo
   Vetrano, Filippo
   Miceli, Alessandro
   Giglia, Giuseppe
   Ferraro, Giuseppe
   Sardo, Pierangelo
   Gambino, Giuditta
TI Golden Tomato Juice Enhances Hepatic PPAR-α Expression, Mitigates
   Metabolic Dysfunctions and Influences Redox Balance in a High-Fat-Diet
   Rat Model
SO ANTIOXIDANTS
LA English
DT Article
DE oxylipin; metabolic syndrome; PPAR-alpha; leptin; oxidative stress;
   functional food
ID PROLIFERATOR-ACTIVATED-RECEPTOR; OXIDATIVE STRESS LEVELS; ACID; GAMMA;
   SUPPLEMENTATION; DEFINITION; PROMOTER; IMPACT; LEVEL; LIVER
AB Golden tomato (GT), harvested at the veraison stage, has gained attention due to its rich content of bioactive compounds and potential health benefits. Previous studies have highlighted GT's antioxidant properties and its positive effects on metabolic syndrome (MetS), a condition characterized by obesity, dyslipidemia, and oxidative stress. This study investigates for the first time a derivative from GT, i.e., the juice (GTJ), which could be a potential candidate for development as a functional food. We first characterized GT juice, identifying 9-oxo-10(E),12(E)-octadecadienoic (9-oxo-10(E),12(E)-ODA) fatty acid, a known peroxisome proliferator-activated receptor alpha (PPAR-alpha) agonist, using High-Performance Liquid Chromatography (HPLC)-mass spectrometry. Then, using a high-fat-diet (HFD) rat model, we assessed the impact of daily GT juice supplementation in addressing MetS. We outlined that GTJ improved body weight and leptin-mediated food intake. Moreover, it ameliorated glucose tolerance, lipid profile, systemic redox homeostasis, hepatic oxidative stress, and steatosis in HFD rats. Furthermore, GT juice enhances the hepatic transcription of PPAR-alpha, thus putatively promoting fatty acid oxidation and lipid metabolism. These findings suggest that GT juice mitigates lipidic accumulation and putatively halters oxidative species at the hepatic level through PPAR-alpha activation. Our study underscores the protective effects of GT juice against MetS, highlighting its future potential as a nutraceutical for improving dysmetabolism and associated alterations.
C1 [Di Majo, Danila; Ricciardi, Nicolo; Frinchi, Monica; Di Liberto, Valentina; Rappa, Francesca; Giglia, Giuseppe; Ferraro, Giuseppe; Sardo, Pierangelo; Gambino, Giuditta] Univ Palermo, Dept Biomed Neurosci & Adv Diagnost BIND, I-90127 Palermo, Italy.
   [Di Majo, Danila; Allegra, Mario; Giglia, Giuseppe; Ferraro, Giuseppe; Sardo, Pierangelo; Gambino, Giuditta] Univ Palermo, Postgrad Sch Nutr & Food Sci, I-90100 Palermo, Italy.
   [Moncada, Alessandra; Saiano, Filippo; Vetrano, Filippo; Miceli, Alessandro] Univ Palermo, Dept Agr Food & Forest Sci SAAF, I-90128 Palermo, Italy.
   [Allegra, Mario] Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol STEBICEF, Viale Sci, I-90128 Palermo, Italy.
   [Pitonzo, Rosa] ATeN Adv Technol Network Ctr, I-90128 Palermo, Italy.
   [Giglia, Giuseppe] Euro Mediterranean Inst Sci & Technol IEMEST, I-90139 Palermo, Italy.
C3 University of Palermo; University of Palermo; University of Palermo;
   University of Palermo
RP Di Majo, D (corresponding author), Univ Palermo, Dept Biomed Neurosci & Adv Diagnost BIND, I-90127 Palermo, Italy.; Di Majo, D (corresponding author), Univ Palermo, Postgrad Sch Nutr & Food Sci, I-90100 Palermo, Italy.
EM danila.dimajo@unipa.it; nicolo.ricciardi@unipa.it;
   alessandra.moncada@unipa.it; mario.allegra@unipa.it;
   monica.frinchi@unipa.it; valentina.diliberto@unipa.it;
   rosa.pitonzo@unipa.it; francesca.rappa@unipa.it;
   filippo.saiano@unipa.it; filippo.vetrano@unipa.it;
   alessandro.miceli@unipa.it; giuseppe.giglia@unipa.it;
   giuseppe.ferraro@unipa.it; pierangelo.sardo@unipa.it;
   giuditta.gambino@unipa.it
RI Moncada, alessandra/GYR-3695-2022; Miceli, Alessandro/HLW-5981-2023; Di
   Majo, Danila/A-9078-2015; Allegra, Mario/AAG-3256-2019; Giglia,
   Giuseppe/M-7100-2016; Di+Liberto, Valentina/ACL-0264-2022; Francesca,
   Rappa/ADW-8431-2022
OI Frinchi, Monica/0000-0002-1061-5725
FU FFR 2023 [FFR 2023]; University of Palermo [DR41862023, Rep.Numb.:
   1105/2023]
FX This work was supported partly via funds "FFR 2023" provided to Gambino
   and Di Majo by University of Palermo and partly with funds "INCENTIVI AD
   ATTIVITA' DI RICERCA INTERDISCIPLINARE DR41862023" (Rep.Numb.:
   1105/2023, Prot.Numb.:135120/2023) provided to Danila Di Majo by
   University of Palermo.
CR Al Dhaheri AS, 2023, J NUTR SCI, V12, DOI 10.1017/jns.2023.52
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Bahne E, 2018, JCI INSIGHT, V3, DOI 10.1172/jci.insight.93936
   Rosa CDB, 2015, ADV NUTR, V6, P703, DOI 10.3945/an.115.009480
   Bowe JE, 2014, J ENDOCRINOL, V222, pG13, DOI 10.1530/JOE-14-0182
   Cámara M, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.849841
   Cheng HM, 2017, ATHEROSCLEROSIS, V257, P100, DOI 10.1016/j.atherosclerosis.2017.01.009
   Collins EJ, 2022, BIOLOGY-BASEL, V11, DOI 10.3390/biology11020239
   Contreras AV, 2013, ADV NUTR, V4, P439, DOI 10.3945/an.113.003798
   Cruz-Carrin A, 2021, FOOD FUNCT, V12, P8340, DOI [10.1039/D1FO00955A, 10.1039/d1fo00955a]
   Cuevas-Ramos D, 2013, DIABET METAB SYND OB, V6, P263, DOI 10.2147/DMSO.S48858
   Di Majo D, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12010089
   Di Majo D, 2022, NUTRIENTS, V14, DOI 10.3390/nu14122384
   Ding GL, 2007, CARDIOVASC RES, V76, P269, DOI 10.1016/j.cardiores.2007.06.027
   Flores P, 2012, FOOD CHEM, V132, P1049, DOI 10.1016/j.foodchem.2011.10.064
   Fuior EV, 2023, BIOMEDICINES, V11, DOI 10.3390/biomedicines11102696
   Gambino G, 2024, J FUNCT FOODS, V112, DOI 10.1016/j.jff.2023.105964
   Gambino G, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12051121
   Gambino G, 2020, BRAIN SCI, V10, DOI 10.3390/brainsci10120908
   Ghadge AA, 2019, CYTOKINE, V121, DOI 10.1016/j.cyto.2019.154735
   Giammanco M, 2018, J BIOL RES-BOLL SOC, V91, P108, DOI 10.4081/jbr.2018.7755
   Grygiel-Górniak B, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-17
   Haluzík MM, 2006, PHYSIOL RES, V55, P115, DOI 10.33549/physiolres.930744
   Hawkes HJK, 2014, BBA-GEN SUBJECTS, V1840, P303, DOI 10.1016/j.bbagen.2013.09.013
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Islam N., 2017, Anwer Khan Mod. Med. Coll. J, V8, P30, DOI [10.3329/akmmcj.v8i1.31655, DOI 10.3329/AKMMCJ.V8I1.31655]
   Jansen E, 2015, INT J MOL SCI, V16, P27378, DOI 10.3390/ijms161126032
   Kim B, 2015, EXP MOL MED, V47, DOI 10.1038/emm.2015.3
   Kim YI, 2011, MOL NUTR FOOD RES, V55, P585, DOI 10.1002/mnfr.201000264
   Lee S, 2017, FREE RADICAL RES, V51, P179, DOI 10.1080/10715762.2017.1291939
   Li L, 2015, J PHARMACOL SCI, V127, P244, DOI 10.1016/j.jphs.2014.12.001
   Li P, 2021, MOL NUTR FOOD RES, V65, DOI 10.1002/mnfr.202100007
   Lin Q, 2007, J BIOL CHEM, V282, P20621, DOI 10.1074/jbc.M607954200
   Macri A, 2015, GRAEF ARCH CLIN EXP, V253, P425, DOI 10.1007/s00417-014-2853-6
   Mancini S, 2017, REDOX REP, V22, P399, DOI 10.1080/13510002.2016.1277049
   Merrill A., 1973, Energy Value of Foods: basis and derivation
   Monsalve FA, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/549627
   Mosblech A, 2009, PLANT PHYSIOL BIOCH, V47, P511, DOI 10.1016/j.plaphy.2008.12.011
   Motojima K, 1998, J BIOL CHEM, V273, P16710, DOI 10.1074/jbc.273.27.16710
   Muzio G, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10111734
   Naureen Zakira, 2022, J Prev Med Hyg, V63, pE4, DOI 10.15167/2421-4248/jpmh2022.63.2S3.2740
   Nouri MHK, 2013, IRAN RED CRESCENT ME, V15, P287, DOI 10.5812/ircmj.1007
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   Oruna-Concha MJ, 2007, J AGR FOOD CHEM, V55, P5776, DOI 10.1021/jf070791p
   Pipitone RM, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1221013
   Pu DD, 2024, CRIT REV FOOD SCI, V64, P3441, DOI 10.1080/10408398.2022.2132209
   Reidy SP, 2000, COMP BIOCHEM PHYS A, V125, P285, DOI 10.1016/S1095-6433(00)00159-8
   Rodríguez-Correa E, 2020, NUTR DIABETES, V10, DOI 10.1038/s41387-020-0127-4
   Scordino M, 2024, CELLS-BASEL, V13, DOI 10.3390/cells13040355
   Shi YG, 2022, FOODS, V11, DOI 10.3390/foods11213408
   Song SL, 2010, MOL CELL ENDOCRINOL, V325, P54, DOI 10.1016/j.mce.2010.05.019
   Spahis S, 2017, ANTIOXID REDOX SIGN, V26, P445, DOI 10.1089/ars.2016.6756
   Takahashi H, 2011, BIOSCI BIOTECH BIOCH, V75, P1621, DOI 10.1271/bbb.110254
   Teruel T, 2000, BIOCHEM BIOPH RES CO, V273, P560, DOI 10.1006/bbrc.2000.2982
   Terzo S, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11010080
   Vatashchuk MV, 2022, BIOMED RES INT, V2022, DOI 10.1155/2022/5850507
   VUDAC N, 1994, J BIOL CHEM, V269, P31012
   Wang YP, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21062061
   Willcox JK, 2003, CRIT REV FOOD SCI, V43, P1, DOI 10.1080/10408690390826437
   Wu JL, 2007, PHYSIOL RES, V56, P213, DOI 10.33549/physiolres.930937
   Yu ST, 2003, CURR MOL MED, V3, P561, DOI 10.2174/1566524033479537
   Zhao MJ, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201801417
   Zhao SG, 2020, MOL METAB, V37, DOI 10.1016/j.molmet.2020.100995
NR 63
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD NOV
PY 2024
VL 13
IS 11
AR 1324
DI 10.3390/antiox13111324
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA N3S4R
UT WOS:001363575800001
PM 39594468
OA gold
DA 2025-06-11
ER

PT J
AU Kishi, T
   Hirooka, Y
   Ogawa, K
   Konno, S
   Sunagawa, K
AF Kishi, Takuya
   Hirooka, Yoshitaka
   Ogawa, Kiyohiro
   Konno, Satomi
   Sunagawa, Kenji
TI Calorie Restriction inhibits Sympathetic Nerve Activity via Anti-Oxidant
   Effect in the Rostral Ventrolateral Medulla of Obesity-Induced
   Hypertensive Rats
SO CLINICAL AND EXPERIMENTAL HYPERTENSION
LA English
DT Article; Proceedings Paper
CT 12th Japanese Annual Conference on Chronocardiology and Hypertension
CY JUL 10, 2010
CL Tokyo, JAPAN
SP Mitsubishi Tanabe Pharma Corp
DE calorie restriction; metabolic syndrome; sympathetic nerve activity;
   oxidative stress; brain
ID NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS; ANGIOTENSIN-II; BLOOD-PRESSURE;
   BRAIN-STEM; PRONE; SYMPATHOEXCITATION; OVEREXPRESSION; ACTIVATION; MODEL
AB In the patients and animals with metabolic syndrome (MetS), sympathetic nerve activity (SNA) is increased. We have demonstrated that oxidative stress in the rostral ventrolateral medulla (RVLM), a vasomotor center in the brainstem, increases SNA. The aim of the present study was to determine whether calorie restriction inhibits SNA via anti-oxidant effect in the RVLM of obesity-induced obesity rats. Male Sprague-Dawley rats were fed on a high-fat diet and segregated into obesity-prone (OP) showing a MetS profile and obesity-resistant (OR) after 13 weeks. Obesity-prone was divided into OP treated with calorie restriction (CR-OP) for 8 weeks and control (CTR-OP). Systolic blood pressure (SBP), heart rate (HR), SNA, and thiobarbituric acid-reactive substances (TBARS) levels as a marker of oxidative stress in the RVLM were significantly higher and the depressor effects due to the microinjection of tempol, a superoxide dismutase mimetic into the RVLM, were significantly greater in OP than in OR. Body weight was significantly lower in CR-OP than in CTR-OP. SBP, HR, SNA, TBARS, and the depressor effects due to the microinjection of tempol into the RVLM were significantly lower in CR-OP than in CTR-OP. These results suggest that calorie restriction inhibits SNA via anti-oxidant effect in the RVLM of obesity-induced obesity rats.
C1 [Kishi, Takuya] Kyushu Univ, Grad Sch Med Sci, Dept Adv Therapeut Cardiovasc Dis, Dept Cardiovasc Med,Higashi Ku, Fukuoka 8128582, Japan.
C3 Kyushu University
RP Kishi, T (corresponding author), Kyushu Univ, Grad Sch Med Sci, Dept Adv Therapeut Cardiovasc Dis, Dept Cardiovasc Med,Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan.
EM tkishi@cardiol.med.kyushu-u.ac.jp
RI Kishi, Takuya/ITU-1075-2023
CR Boustany CM, 2004, AM J PHYSIOL-REG I, V287, pR943, DOI 10.1152/ajpregu.00265.2004
   DAMPNEY RAL, 1994, PHYSIOL REV, V74, P323, DOI 10.1152/physrev.1994.74.2.323
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   Delbosc S, 2005, ATHEROSCLEROSIS, V179, P43, DOI 10.1016/j.atherosclerosis.2004.10.018
   Dobrian AD, 2001, HYPERTENSION, V37, P554, DOI 10.1161/01.HYP.37.2.554
   Dobrian AD, 2004, HYPERTENSION, V43, P48, DOI 10.1161/01.HYP.0000103629.01745.59
   Esler M, 2006, HYPERTENSION, V48, P787, DOI 10.1161/01.HYP.0000242642.42177.49
   Ferguson AV, 1998, PROG NEUROBIOL, V54, P169, DOI 10.1016/S0301-0082(97)00065-8
   Guyenet PG, 2006, NAT REV NEUROSCI, V7, P335, DOI 10.1038/nrn1902
   Hirooka Y, 2003, J CARDIOVASC PHARM, V42, pS111, DOI 10.1097/00005344-200312001-00023
   Hirooka Y, 2003, J CARDIOVASC PHARM, V41, pS119
   Hirooka Y, 2001, ANN NY ACAD SCI, V940, P197
   Holloszy JO, 2007, EXP GERONTOL, V42, P709, DOI 10.1016/j.exger.2007.03.009
   Kishi T, 2002, HYPERTENSION, V39, P264, DOI 10.1161/hy0202.102701
   Kishi T, 2001, HYPERTENSION, V38, P896, DOI 10.1161/hyp.38.4.896
   Kishi T, 2004, CIRCULATION, V109, P2357, DOI 10.1161/01.CIR.0000128695.49900.12
   Kishi T, 2008, CLIN EXP HYPERTENS, V30, P3, DOI 10.1080/10641960701813429
   Kishi T, 2010, HYPERTENSION, V55, P291, DOI 10.1161/HYPERTENSIONAHA.109.138636
   Lauterio TJ, 1999, OBES RES, V7, P498, DOI 10.1002/j.1550-8528.1999.tb00439.x
   Matsui H, 2008, HYPERTENSION, V52, P287, DOI 10.1161/HYPERTENSIONAHA.108.111815
   Nagae A, 2009, CIRCULATION, V119, P978, DOI 10.1161/CIRCULATIONAHA.108.824730
   Nozoe M, 2008, J HYPERTENS, V26, P2176, DOI 10.1097/HJH.0b013e32830dd5d3
   Nozoe M, 2007, HYPERTENSION, V50, P62, DOI 10.1161/HYPERTENSIONAHA.107.087981
   PEDROZO H, 1994, AGE, V17, P23, DOI 10.1007/BF02435046
   Sakai K, 2005, AM J PHYSIOL-HEART C, V289, pH2159, DOI 10.1152/ajpheart.00408.2005
   Smith AD, 2006, EXP BIOL MED, V231, P282
   Stocker SD, 2007, HYPERTENSION, V49, P640, DOI 10.1161/01.HYP.0000254828.71253.dc
   Teske JA, 2009, AM J PHYSIOL-REG I, V297, pR176, DOI 10.1152/ajpregu.90866.2008
   YOUNG JB, 1978, METABOLISM, V27, P1711, DOI 10.1016/0026-0495(78)90256-1
   Zhang XC, 2005, EXP NEUROL, V191, P318, DOI 10.1016/j.expneurol.2004.10.011
   Zimmerman MC, 2004, CIRC RES, V95, P210, DOI 10.1161/01.RES.0000135483.12297.e4
   Zimmerman MC, 2002, CIRC RES, V91, P1038, DOI 10.1161/01.RES.0000043501.47934.FA
NR 32
TC 31
Z9 31
U1 0
U2 4
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1064-1963
EI 1525-6006
J9 CLIN EXP HYPERTENS
JI Clin. Exp. Hypertens.
PY 2011
VL 33
IS 4
BP 240
EP 245
DI 10.3109/10641963.2011.583969
PG 6
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA 782VM
UT WOS:000292040800006
PM 21699450
DA 2025-06-11
ER

PT J
AU Campanholo, CB
   Maharaj, AB
   Corp, N
   Bell, S
   Costa, L
   de Vlam, K
   Gullick, NJ
   Khraishi, M
   Kishimoto, M
   Palmou-Fontana, N
   Reddy, S
   Scarpa, R
   Vega, L
   Duarte, GV
   Zisman, D
   Windt, DAV
   Duruoz, MT
   Ogdie, A
AF Campanholo, Cristiano B.
   Maharaj, Ajesh B.
   Corp, Nadia
   Bell, Stacie
   Costa, Luisa
   de Vlam, Kurt
   Gullick, Nicola J.
   Khraishi, Majed
   Kishimoto, Mitsumasa
   Palmou-Fontana, Natalia
   Reddy, Soumya
   Scarpa, Raffaele
   Vega, Luis
   Duarte, Gleison Vieira
   Zisman, Devy
   Windt, Danielle A. van der
   Duruoz, Mehmet T.
   Ogdie, Alexis
TI Management of Psoriatic Arthritis in Patients With Comorbidities: An
   Updated Literature Review Informing the 2021 GRAPPA Treatment
   Recommendations
SO JOURNAL OF RHEUMATOLOGY
LA English
DT Review
DE comorbidities; GRAPPA; psoriatic arthritis; treatments
ID METABOLIC SYNDROME; RHEUMATOID-ARTHRITIS; INCREASED PREVALENCE;
   WEIGHT-LOSS; TNF-ALPHA; RISK; DISEASE; SECUKINUMAB; METHOTREXATE;
   MALIGNANCY
AB Objective. The 2021 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) treatment recommendations provide an evidence-based guide for selecting therapy based on the individual's disease features. Beyond the disease features and associated conditions (eg, uveitis and inflammatory bowel disease), comorbidities play an important role in selecting therapy for an individual patient.Methods. We performed a systematic literature review. We examined the available evidence to inform treat-ment selection based on the presence or absence of comorbidities in psoriatic arthritis (PsA). Results. Common comorbidities in PsA that may affect treatment selection include presence of baseline car-diovascular disease (CVD) or high risk for CVD, obesity and metabolic syndrome, liver disease, mood dis-orders, including depression in particular, chronic infections, malignancies, osteoporosis, and fibromyalgia and/or central sensitization.Conclusion. Comorbidities may influence both the effectiveness of a given therapy but also the potential for adverse events. It is important to assess for the presence of comorbidities prior to therapy selection.
C1 [Maharaj, Ajesh B.] Life Westville Hosp, Life Healthcare, Westville, South Africa.
   [Corp, Nadia] Keele Univ, Sch Med, Primary Care Ctr Versus Arthrit, Keele, Staffs, England.
   [Bell, Stacie] Natl Psoriasis Fdn, Portland, OR USA.
   [Costa, Luisa] Univ Naples Federico II, Dept Clin Med & Surg, Naples, Italy.
   [de Vlam, Kurt] Univ Hosp Leuven, Dept Rheumatol, Leuven, Belgium.
   [Gullick, Nicola J.] Univ Warwick, Univ Hosp Coventry Warwickshire, Dept Rheumatol, Coventry, W Midlands, England.
   [Gullick, Nicola J.] Univ Warwick, Warwick Med Sch, Coventry, W Midlands, England.
   [Khraishi, Majed] Mem Univ Newfoundland, St John, NF, Canada.
   [Kishimoto, Mitsumasa] Kyorin Univ, Dept Nephrol & Rheumatol, Sch Med, Tokyo, Japan.
   [Palmou-Fontana, Natalia] Marques Valdecilla Univ Hosp, Rheumatol Deparment, Cantabria, Spain.
   [Reddy, Soumya] NYU, Grossman Sch Med, New York, NY USA.
   [Scarpa, Raffaele] Univ Naples Federico II, Dept Clin Med & Surg, Naples, Italy.
   [Vega, Luis] Cent Hosp Peruvian Air Force, Rheumatol Sect, Lima, Peru.
   [Duarte, Gleison Vieira] Inst Bahiano Imunoterapia, Dermatol Div IBIS, Salvador, BA, Brazil.
   [Zisman, Devy] Carmel Hosp, Rheumatol Unit, Techn, Haifa, Israel.
   [Zisman, Devy] Ruth & Bruce Rappaport Fac Med, Techn, Haifa, Israel.
   [Windt, Danielle A. van der] Keele Univ, Sch Med, Primary Care Ctr Versus Arthrit, Keele, Staffs, England.
   [Duruoz, Mehmet T.] Marmara Univ, Div Rheumatol, PMR Dept, Sch Med, Istanbul, Turkiye.
   [Ogdie, Alexis] Univ Penn, Perelman Sch Med, Philadelphia, PA USA.
C3 Keele University; University of Naples Federico II; KU Leuven;
   University Hospital Leuven; University of Warwick; University of
   Warwick; Memorial University Newfoundland; Kyorin University; Hospital
   Universitario Marques de Valdecilla (HUMV); New York University;
   University of Naples Federico II; Clalit Health Services; Carmel Medical
   Center; Technion Israel Institute of Technology; Rappaport Faculty of
   Medicine; Keele University; Marmara University; University of
   Pennsylvania
RP Ogdie, A (corresponding author), Univ Pennsylvania, Perelman Sch Med, White 5023,3400 Spruce St, Philadelphia, PA 19104 USA.
EM ogdiea@pennmedicine.upenn.edu
RI Gullick, Nicola/GWZ-1369-2022; Corp, Nadia/G-8618-2012; PALMOU-FONTANA,
   NATALIA/AAZ-6454-2020; Duruöz, Mehmet Tuncay/I-2307-2016; Maharaj,
   Ajesh/M-3138-2014
OI kishimoto, Mitsumasa/0000-0002-4007-1589; Bell,
   Stacie/0000-0002-9987-567X; Corp, Nadia/0000-0002-6758-9513; Gullick,
   Nicola/0000-0001-8970-4116; van der Windt, Danielle/0000-0002-7248-6703;
   Maharaj, Ajesh/0000-0002-9436-4328; Palmou Fontana,
   Natalia/0000-0002-8609-0283
FU AbbVie; AstraZeneca; Izana; Lilly; Novartis; Pfizer; UCB; MSD; Amgen
FX ABM is a consultant and received honoraria from Janssen, ThermoFisher,
   Roche, Novartis, AbbVie, Eli Lilly, AstraZeneca, Pfizer, Zydus. LC
   received consultancy fees and/or lecturers' honoraria from AbbVie,
   Amgen, Novartis, Janssen, Lilly. NC consulted for and received honoraria
   from AbbVie, Celgene, Janssen, Lilly, Novartis, Pfizer, and UCB; and
   research funding from AbbVie, AstraZeneca, Izana, Lilly, and Novartis;
   and conference support from Celgene, Janssen, Lilly, UCB. M. Khraishi is
   a consultant for AbbVie, Amgen, Eli Lilly, Novartis, Pfizer. M.
   Kishimoto received consulting fees and/or lecturers' honoraria from
   AbbVie, Amgen-Astellas, Asahi-Kasei, Astellas, Ayumi, BMS, Chugai,
   Daiichi-Sankyo, Eisai, Eli Lilly, Gilead, Janssen, Kyowa Kirin,
   Novartis, Ono, Pfizer, Tanabe-Mitsubishi, Teijin, UCB. SR has consulted
   for Novartis, Janssen, AbbVie, UCB. GVD received consultancy fees and/or
   lecturers' honoraria from Novartis, Janssen, AbbVie, Lilly, UCB,
   Sanofi-Aventis. RS received consultancy fees and/or lecturers' honoraria
   from AbbVie, Amgen, Novartis, Lilly. DZ received consulting fees and/or
   lecturers' honoraria from AbbVie, Eli Lilly, Gilead, Janssen, Novartis,
   Pfizer; and grant support from Pfizer, UCB, MSD. MTD received
   consultancy fees and/or lecturers' honoraria from AbbVie, Amgen,
   Novartis, Janssen, Lilly. AO has consulted for AbbVie, Amgen, BMS,
   Celgene, CorEvitas, Gilead, Janssen, Kopa, Lilly, MoonLake, Novartis,
   Pfizer, UCB; and has received grant support from AbbVie, Amgen,
   Novartis, Pfizer. CBC, SB, KdeV, NJG, NPF, LV, and DAvdW declare no
   conflicts relevant to this article.
CR Amital H, 2009, RHEUMATOLOGY, V48, P1107, DOI 10.1093/rheumatology/kep176
   Atteno M, 2014, CLIN RHEUMATOL, V33, P543, DOI 10.1007/s10067-014-2536-z
   Ballegaard C, 2018, ARTHRIT CARE RES, V70, P592, DOI 10.1002/acr.23333
   Bergman M, 2017, ARTHRITIS RES THER, V19, DOI 10.1186/s13075-017-1265-5
   Caso F, 2018, CLIN RHEUMATOL, V37, P579, DOI 10.1007/s10067-017-3975-0
   Costa L, 2014, CLIN RHEUMATOL, V33, P273, DOI 10.1007/s10067-013-2378-0
   Curtis JR, 2010, ANN RHEUM DIS, V69, P43, DOI 10.1136/ard.2008.101378
   Deyab G, 2017, ARTHRITIS RES THER, V19, DOI 10.1186/s13075-017-1439-1
   Di Minno MND, 2014, ANN RHEUM DIS, V73, P1157, DOI 10.1136/annrheumdis-2012-202812
   Eder L, 2018, ARTHRITIS RHEUMATOL, V70, P408, DOI 10.1002/art.40366
   Ferraz-Amaro I, 2020, MEDICINA-LITHUANIA, V56, DOI 10.3390/medicina56080415
   Furer V, 2020, ANN RHEUM DIS, V79, P39, DOI 10.1136/annrheumdis-2019-215882
   Gisondi P, 2008, AM J CLIN NUTR, V88, P1242, DOI 10.3945/ajcn.2008.26427
   Gulati AM, 2018, RMD OPEN, V4, DOI 10.1136/rmdopen-2017-000631
   Hagberg KW, 2016, JCR-J CLIN RHEUMATOL, V22, P241, DOI 10.1097/RHU.0000000000000364
   Haroon M, 2014, J RHEUMATOL, V41, P1357, DOI 10.3899/jrheum.140021
   Havrdová E, 2016, J NEUROL, V263, P1287, DOI 10.1007/s00415-016-8128-x
   Hellgren K, 2017, ANN RHEUM DIS, V76, P105, DOI 10.1136/annrheumdis-2016-209270
   Jamnitski A, 2013, ANN RHEUM DIS, V72, P211, DOI 10.1136/annrheumdis-2011-201194
   Kavanaugh Arthur, 2020, J Rheumatol Suppl, V96, P41, DOI 10.3899/jrheum.200126
   Klingberg E, 2019, ARTHRITIS RES THER, V21, DOI 10.1186/s13075-019-1810-5
   Kwok TSH, 2022, ARTHRIT CARE RES, V74, P1006, DOI 10.1002/acr.24538
   Langman G, 2001, J GASTROEN HEPATOL, V16, P1395, DOI 10.1046/j.1440-1746.2001.02644.x
   Lewinson RT, 2017, J INVEST DERMATOL, V137, P828, DOI 10.1016/j.jid.2016.11.032
   Li WQ, 2012, ANN RHEUM DIS, V71, P1267, DOI 10.1136/annrheumdis-2011-201273
   Liu CY, 2019, AM J CLIN DERMATOL, V20, P201, DOI 10.1007/s40257-018-0399-9
   Luo X, 2019, SEMIN ARTHRITIS RHEU, V48, P626, DOI 10.1016/j.semarthrit.2018.05.009
   Magrey MN, 2013, ARTHRITIS, DOI 10.1155/2013/762921
   McDonough E, 2014, J RHEUMATOL, V41, P887, DOI 10.3899/jrheum.130797
   McInnes IB, 2015, LANCET, V386, P1137, DOI 10.1016/S0140-6736(15)61134-5
   Mease P, 2019, ARTHRIT CARE RES, V71, P367, DOI 10.1002/acr.23738
   Mease PJ, 2015, NEW ENGL J MED, V373, P1329, DOI 10.1056/NEJMoa1412679
   Menter A, 2020, J AM ACAD DERMATOL, V82, P1445, DOI 10.1016/j.jaad.2020.02.044
   Menter A, 2019, J AM ACAD DERMATOL, V80, P1029, DOI 10.1016/j.jaad.2018.11.057
   Mori S, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0203084
   Nissen SE, 2016, NEW ENGL J MED, V375, P2519, DOI 10.1056/NEJMoa1611593
   Ogdie A, 2018, J INVEST DERMATOL, V138, P760, DOI 10.1016/j.jid.2017.10.024
   Ogdie A, 2018, EUR HEART J, V39, P3608, DOI 10.1093/eurheartj/ehx145
   Ogdie A, 2017, RHEUMATOLOGY, V56, P907, DOI 10.1093/rheumatology/kew502
   Özkan SG, 2017, EUR J RHEUMATOL, V4, P40, DOI 10.5152/eurjrheum.2017.16052
   Pehlevan S, 2014, METAB SYNDR RELAT D, V12, P43, DOI 10.1089/met.2013.0039
   Raychaudhuri SK, 2010, METAB SYNDR RELAT D, V8, P331, DOI 10.1089/met.2009.0124
   Rohekar S, 2008, ARTHRITIS RHEUM-US, V58, P82, DOI 10.1002/art.23185
   Sammaritano LR, 2020, ARTHRITIS RHEUMATOL, V72, P529, DOI 10.1002/art.41191
   Seitz M, 2010, ANN RHEUM DIS, V69, P1148, DOI 10.1136/ard.2009.116194
   Sharma A, 2013, INT J RHEUM DIS, V16, P667, DOI 10.1111/1756-185X.12134
   Sokolove J, 2010, ANN RHEUM DIS, V69, P1612, DOI 10.1136/ard.2009.112136
   Thompson AE, 2011, ARTHRITIS RHEUM-US, V63, P1479, DOI 10.1002/art.30310
   Tilling L, 2006, CLIN DRUG INVEST, V26, P55, DOI 10.2165/00044011-200626020-00001
   Zisman D, 2016, ANN RHEUM DIS, V75, P131, DOI 10.1136/annrheumdis-2013-205148
NR 50
TC 16
Z9 16
U1 1
U2 2
PU J RHEUMATOL PUBL CO
PI TORONTO
PA 365 BLOOR ST E, STE 901, TORONTO, ONTARIO M4W 3L4, CANADA
SN 0315-162X
EI 1499-2752
J9 J RHEUMATOL
JI J. Rheumatol.
PD MAR 1
PY 2023
VL 50
IS 3
BP 426
EP 432
DI 10.3899/jrheum.220310
PG 7
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA I7ST6
UT WOS:001004755200018
PM 36319003
OA Bronze, Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Baskaran, A
   Cha, DS
   Powell, AM
   Jalil, D
   McIntyre, RS
AF Baskaran, Anusha
   Cha, Danielle S.
   Powell, Alissa M.
   Jalil, Dalya
   McIntyre, Roger S.
TI Sex differences in rates of obesity in bipolar disorder: postulated
   mechanisms
SO BIPOLAR DISORDERS
LA English
DT Review
DE bipolar disorder; female; metabolic syndrome; obesity; women
ID POLYCYSTIC-OVARY-SYNDROME; METABOLIC SYNDROME; WEIGHT-GAIN;
   GENDER-DIFFERENCES; UNITED-STATES; BODY-MASS; DEPRESSIVE SYMPTOMS;
   REPRODUCTIVE EVENTS; MOOD DISORDERS; WOMEN
AB ObjectiveThe increased standardized mortality ratio (SMR) from cardiovascular disease (CVD) in women with bipolar disorder (BD), relative to men with BD and individuals of both sexes in the general population, provides the impetus to identify factors that contribute to the differential association of obesity with BD in women.
   MethodsWe conducted a selective PubMed search of English-language articles published from September 1990 to June 2012. The key search terms were bipolar disorder and metabolic syndrome cross-referenced with gender, sex, obesity, diabetes mellitus, hypertension, and dyslipidemia. The search was supplemented with a manual review of relevant article reference lists. Articles selected for review were based on author consensus, the use of a standardized experimental procedure, validated assessment measures, and overall manuscript quality.
   ResultsIt is amply documented that adults with BD are affected by the metabolic syndrome at a rate higher than the general population. Women with BD, when compared to men with BD and individuals of both sexes in the general population, have higher rates of abdominal obesity. The course and clinical presentation of BD manifest differently in men and women, wherein women exhibit a higher frequency of depression predominant illness, a later onset of BD, more seasonal variations in mood disturbance, and increased susceptibility to relapse. Phenomenological factors can be expanded to include differences in patterns of comorbidity between the sexes among patients with BD. Other factors that contribute to the increased risk for abdominal obesity in female individuals with BD include reproductive life events, anamnestic (e.g., sexual and/or physical abuse), lifestyle, and iatrogenic.
   ConclusionsA confluence of factors broadly categorized as broad- and sex-based subserve the increased rate of obesity in women with BD. It remains a testable hypothesis that the increased abdominal obesity in women with BD mediates the increased SMR from CVD. A clinical recommendation that emerges from this review is amplified attention to the appearance, or history, of factors that conspire to increase obesity in female patients with BD.
C1 [Baskaran, Anusha] Queens Univ, Ctr Neurosci Studies, Kingston, ON, Canada.
   [Baskaran, Anusha; Cha, Danielle S.; Powell, Alissa M.; Jalil, Dalya; McIntyre, Roger S.] Univ Toronto, Mood Disorders Psychopharmacol Unit, Univ Hlth Network, Toronto, ON M5T 2S8, Canada.
   [Cha, Danielle S.; Powell, Alissa M.; McIntyre, Roger S.] Univ Toronto, Dept Psychiat, Toronto, ON M5T 2S8, Canada.
C3 Queens University - Canada; University of Toronto; University Health
   Network Toronto; University of Toronto
RP McIntyre, RS (corresponding author), Univ Toronto, Mood Disorders Psychopharmacol Unit, Univ Hlth Network, Dept Psychiat, 399 Bathurst St, Toronto, ON M5T 2S8, Canada.
EM roger.mcintyre@uhn.ca
RI McIntyre, Roger/AAU-1000-2020
CR Alciati A, 2011, INT J PSYCHIAT MED, V41, P155, DOI 10.2190/PM.41.2.e
   Amianto F, 2011, J AFFECT DISORDERS, V133, P580, DOI 10.1016/j.jad.2011.04.049
   Andersen SW, 2005, J CLIN PSYCHIAT, V66, P1468, DOI 10.4088/JCP.v66n1118
   Andreazza AC, 2009, J PSYCHIATR NEUROSCI, V34
   [Anonymous], 2005, J Psychopharmacol, V19, P188
   Apridonidze T, 2005, J CLIN ENDOCR METAB, V90, P1929, DOI 10.1210/jc.2004-1045
   Arnold LM, 2003, PSYCHIAT CLIN N AM, V26, P595, DOI 10.1016/S0193-953X(03)00036-4
   Avis Nancy E., 1994, Annals of Epidemiology, V4, P214
   Banaszewska B, 2006, AM J OBSTET GYNECOL, V194, P1266, DOI 10.1016/j.ajog.2005.11.009
   Barfield E, 2009, J PEDIATR ADOL GYNEC, V22, P318, DOI 10.1016/j.jpag.2009.03.003
   Barnes C, 2005, AUST NZ J PSYCHIAT, V39, P662, DOI 10.1080/j.1440-1614.2005.01650.x
   Baskin SM, 2009, NEUROL SCI, V30, pS61, DOI 10.1007/s10072-009-0071-5
   Bastian LA, 2005, PREV MED, V40, P99, DOI 10.1016/j.ypmed.2004.05.007
   Bond DJ, 2010, J AFFECT DISORDERS, V124, P108, DOI 10.1016/j.jad.2009.10.023
   Bowden CL, 2003, BIPOLAR DISORD, V5, P189, DOI 10.1034/j.1399-5618.2003.00031.x
   BROWN SL, 1995, J CLIN EPIDEMIOL, V48, P445, DOI 10.1016/0895-4356(94)00188-V
   Burkert NT, 2012, WIEN KLIN WOCHENSCHR, V124, P271, DOI 10.1007/s00508-012-0160-y
   Cassidy F, 2002, EUR ARCH PSY CLIN N, V252, P110, DOI 10.1007/s00406-002-0367-4
   Chandra PS, 2002, ACTA PSYCHIAT SCAND, V106, P76, DOI 10.1034/j.1600-0447.2002.t01-2-02001.x
   Chapman BP, 2009, HEALTH PSYCHOL, V28, P419, DOI 10.1037/a0015212
   Collins PY, 2011, NATURE, V475, P27, DOI 10.1038/475027a
   Conus P, 2010, BIPOLAR DISORD, V12, P244, DOI 10.1111/j.1399-5618.2010.00813.x
   Covell NH, 2004, SCHIZOPHRENIA BULL, V30, P229, DOI 10.1093/oxfordjournals.schbul.a007074
   Daruy L, 2011, ACTA PSYCHIAT SCAND, V124, P427, DOI 10.1111/j.1600-0447.2011.01756.x
   Diflorio A, 2010, INT REV PSYCHIATR, V22, P437, DOI 10.3109/09540261.2010.514601
   Elmslie JL, 2001, J CLIN PSYCHIAT, V62, P486, DOI 10.4088/JCP.v62n0614
   Epstein LH, 2009, PSYCHOL REV, V116, P384, DOI 10.1037/a0015074
   Fava M, 1998, Ann Clin Psychiatry, V10, P145
   Felitti VJ, 1998, AM J PREV MED, V14, P245, DOI 10.1016/S0749-3797(98)00017-8
   Fiedorowicz JG, 2008, ANN CLIN PSYCHIATRY, V20, P131, DOI 10.1080/10401230802177722
   Ford ES, 2005, DIABETES CARE, V28, P2745, DOI 10.2337/diacare.28.11.2745
   Freeman EW, 2006, ARCH GEN PSYCHIAT, V63, P375, DOI 10.1001/archpsyc.63.4.375
   Freeman MP, 2005, ACTA PSYCHIAT SCAND, V112, P88, DOI 10.1111/j.1600-0447.2005.00526.x
   Freeman MP, 2002, J CLIN PSYCHIAT, V63, P284, DOI 10.4088/JCP.v63n0403
   Frye MA, 2009, ACTA PSYCHIAT SCAND, V120, P10, DOI 10.1111/j.1600-0447.2008.01343.x
   Garcia-Portilla MP, 2008, J AFFECT DISORDERS, V106, P197, DOI 10.1016/j.jad.2007.06.002
   Goldstein BI, 2011, BIPOLAR DISORD, V13, P387, DOI 10.1111/j.1399-5618.2011.00932.x
   Harris HE, 1999, J PSYCHOSOM OBST GYN, V20, P65, DOI 10.3109/01674829909075579
   Hartlage SA, 2001, J CLIN PSYCHOL, V57, P1571, DOI 10.1002/jclp.1119
   Holt RIG, 2009, DIABETES OBES METAB, V11, P665, DOI 10.1111/j.1463-1326.2009.01038.x
   Hruschka DJ, 2012, AM J HUM BIOL, V24, P277, DOI 10.1002/ajhb.22231
   Huerta R, 1995, PSYCHONEUROENDOCRINO, V20, P851, DOI 10.1016/0306-4530(95)00030-5
   HUNTER MS, 1990, MATURITAS, V12, P299, DOI 10.1016/0378-5122(90)90009-U
   Hyun M, 2000, BIPOLAR DISORD, V2, P131, DOI 10.1034/j.1399-5618.2000.020206.x
   Javaras KN, 2008, J CLIN PSYCHIAT, V69, P266, DOI 10.4088/JCP.v69n0213
   Joffe H, 2006, BIOL PSYCHIAT, V59, P1078, DOI 10.1016/j.biopsych.2005.10.017
   Joffe H, 2006, BIOL PSYCHIAT, V60, P1378, DOI 10.1016/j.biopsych.2006.05.027
   Judd LL, 1996, AM J PSYCHIAT, V153, P1411
   Kenna HA, 2009, HARVARD REV PSYCHIAT, V17, P138, DOI 10.1080/10673220902899722
   Kimokoti RW, 2010, J NUTR, V140, P1287, DOI 10.3945/jn.109.120808
   Kleinman NL, 2005, J OCCUP ENVIRON MED, V47, P1117, DOI 10.1097/01.jom.0000177048.34506.fc
   Knochenhauer ES, 1998, J CLIN ENDOCR METAB, V83, P3078, DOI 10.1210/jc.83.9.3078
   Kupfer DJ, 2005, JAMA-J AM MED ASSOC, V293, P2528, DOI 10.1001/jama.293.20.2528
   Lee Hye Ah, 2011, J Prev Med Public Health, V44, P226, DOI 10.3961/jpmph.2011.44.5.226
   Lipton RB, 2001, HEADACHE, V41, P646, DOI 10.1046/j.1526-4610.2001.041007646.x
   Lo JC, 2006, J CLIN ENDOCR METAB, V91, P1357, DOI 10.1210/jc.2005-2430
   Mahé V, 2001, ACTA PSYCHIAT SCAND, V104, P323, DOI 10.1034/j.1600-0447.2001.00288.x
   Malhi GS, 2012, AUST NZ J PSYCHIAT, V46, P192, DOI 10.1177/0004867412437346
   MARKS MN, 1992, J AFFECT DISORDERS, V24, P253, DOI 10.1016/0165-0327(92)90110-R
   Marsh WK, 2009, J PSYCHIATR RES, V43, P798, DOI 10.1016/j.jpsychires.2008.11.003
   McElroy SL, 2004, J CLIN PSYCHIAT, V65, P634
   McIntyre Roger S, 2005, Ann Clin Psychiatry, V17, P83, DOI 10.1080/10401230590932380
   McIntyre RS, 2006, HEADACHE, V46, P973, DOI 10.1111/j.1526-4610.2006.00469.x
   McIntyre RS, 2010, J AFFECT DISORDERS, V126, P366, DOI 10.1016/j.jad.2010.04.012
   McIntyre RS, 2003, BIPOLAR DISORD, V5, P28, DOI 10.1034/j.1399-5618.2003.00009.x
   McLaren Lindsay, 2009, Health Rep, V20, P65
   Oedegaard KJ, 2011, J CLIN PSYCHOPHARM, V31, P734, DOI 10.1097/JCP.0b013e318235f4e9
   Ortiz-Domínguez A, 2007, BIPOLAR DISORD, V9, P596, DOI 10.1111/j.1399-5618.2007.00493.x
   Ösby U, 2001, ARCH GEN PSYCHIAT, V58, P844, DOI 10.1001/archpsyc.58.9.844
   Pacifico L, 2012, CLIN CHIM ACTA, V413, P396, DOI 10.1016/j.cca.2011.11.013
   Pepino MY, 2012, APPETITE, V58, P800, DOI 10.1016/j.appet.2012.01.026
   Pine DS, 2001, PEDIATRICS, V107, P1049, DOI 10.1542/peds.107.5.1049
   Post RM, 2001, DEV PSYCHOPATHOL, V13, P581, DOI 10.1017/S0954579401003091
   Reinehr T, 2010, MOL CELL ENDOCRINOL, V316, P165, DOI 10.1016/j.mce.2009.06.005
   Sathya A, 2009, SINGAP MED J, V50, pe65
   Sit Dorothy, 2004, J Am Med Womens Assoc (1972), V59, P91
   Stephenson Toni, 2010, JAAPA, V23, P20
   Stowell CP, 2005, PSYCHOSOMATICS, V46, P259, DOI 10.1176/appi.psy.46.3.259
   Sussman N, 2001, J CLIN PSYCHIAT, V62, P256, DOI 10.4088/JCP.v62n0407
   Sutin AR, 2012, PSYCHOL MED, V42, P2351, DOI 10.1017/S0033291712000566
   Taylor V, 2006, J CLIN PSYCHIAT, V67, P1034, DOI 10.4088/JCP.v67n0704
   Tirupati S, 2007, AUST NZ J PSYCHIAT, V41, P606, DOI 10.1080/00048670701392841
   van Winkel R, 2008, BIPOLAR DISORD, V10, P342, DOI 10.1111/j.1399-5618.2007.00520.x
   Vega P, 2011, WOMENS HEALTH, V7, P663, DOI [10.2217/WHE.11.71, 10.2217/whe.11.71]
   Viguera AC, 2000, AM J PSYCHIAT, V157, P179, DOI 10.1176/appi.ajp.157.2.179
   Vo M, 2011, HEADACHE, V51, P559, DOI 10.1111/j.1526-4610.2010.01833.x
   Wang PS, 2000, J GEN INTERN MED, V15, P284, DOI 10.1046/j.1525-1497.2000.9908044.x
   Whitaker RC, 1997, NEW ENGL J MED, V337, P869, DOI 10.1056/NEJM199709253371301
   Wieck A, 2003, J PSYCHOPHARMACOL, V17, P204, DOI 10.1177/0269881103017002009
   WILLIAMS JBW, 1995, AM J OBSTET GYNECOL, V173, P654, DOI 10.1016/0002-9378(95)90298-8
   Wu RR, 2007, J CLIN PSYCHOPHARM, V27, P374, DOI 10.1097/JCP.0b013e3180cac8db
   Yonkers KA, 2011, OBSTET GYNECOL, V117, P961, DOI 10.1097/AOG.0b013e31821187a7
NR 92
TC 37
Z9 39
U1 1
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1398-5647
EI 1399-5618
J9 BIPOLAR DISORD
JI Bipolar Disord.
PD FEB
PY 2014
VL 16
IS 1
SI SI
BP 83
EP 92
DI 10.1111/bdi.12141
PG 10
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA AA6IT
UT WOS:000331202700009
PM 24467470
DA 2025-06-11
ER

PT J
AU Karagüzel, EO
   Kural, BV
   Tiryaki, A
   Altun, IK
   Özer, SY
   Arslan, FC
AF Karaguzel, Evrim Ozkorumak
   Kural, Birgul Vanizor
   Tiryaki, Ahmet
   Altun, Ilkay Keles
   Ozer, Serap Yaman
   Arslan, Filiz Civil
TI Blood levels of agouti-related peptide (AgRP), obestatin,
   corticosteroid-binding globulin (CBG), and cortisol in patients with
   bipolar disorder (BD): a case-control study
SO PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
LA English
DT Article
DE Bipolar disorder; agouti-related protein; hydrocortisone;
   corticosteroid-binding globulin; obesity
ID PITUITARY-ADRENAL AXIS; METABOLIC SYNDROME; ENERGY-BALANCE;
   RATING-SCALE; GHRELIN; PROTEIN; OBESITY; SECRETION; SCHIZOPHRENIA;
   RELIABILITY
AB OBJECTIVES: Bipolar disorder (BD) is a chronic psychiatric disorder with a high prevalence of obesity. There are a number of hypotheses regarding the association between obesity and BD. One involves common neurobiological abnormalities, such as dysfunction in the hypothalamic pituitary adrenal axis and changes in secretions of orexigenic and anorectic peptides. The purpose of this study was to evaluate the blood levels of agouti-related peptide (AgRP), obestatin cortisol, and corticosteroid-binding globulin (CBG) and metabolic parameters in patients with euthymic BD, and to compare these to those of healthy controls. METHODS: Twenty-nine outpatients with BD type I admitted to the psychiatric clinic were consecutively enrolled and compared with 25 sex- and body mass index (BMI)-matched controls. RESULTS: There was a significant difference in AgRP, cortisol, and CBG levels between patients and the controls (p = .005, .021, and .034, respectively). AgRP and CBG did not correlate with any parameter in BD patients, but cortisol correlated with BMI. CONCLUSIONS: We conclude that BD patients have higher levels of AgRP, cortisol, and CBG than healthy controls with similar BMIs. This may represent a new insight into the neurobiology of BD.
C1 [Karaguzel, Evrim Ozkorumak; Arslan, Filiz Civil] Karadeniz Tech Univ, Fac Med, Dept Psychiat, TR-61080 Trabzon, Turkey.
   [Kural, Birgul Vanizor; Ozer, Serap Yaman] Karadeniz Tech Univ, Fac Med, Dept Med Biochem, Trabzon, Turkey.
   [Tiryaki, Ahmet] Istanbul Aydin Univ, Fac Med, Dept Psychiat, Istanbul, Turkey.
   [Altun, Ilkay Keles] Numune State Hosp, Dept Psychiat, Trabzon, Turkey.
C3 Karadeniz Technical University; Karadeniz Technical University; Istanbul
   Aydin University; Fatih State Hospital
RP Karagüzel, EO (corresponding author), Karadeniz Tech Univ, Fac Med, Dept Psychiat, TR-61080 Trabzon, Turkey.
EM evrimozkorumak@yahoo.com
RI tiryaki, ahmet/GVT-2792-2022; arslan, filiz/N-5677-2019; ozer,
   serap/MDS-9620-2025; Keles Altun, Ilkay/MXL-8477-2025
OI VANIZOR KURAL, Birgul/0000-0003-0730-9660; ozkorumak,
   evrim/0000-0002-0734-5437
CR Akdemir A, 2001, COMPR PSYCHIAT, V42, P161, DOI 10.1053/comp.2001.19756
   [Anonymous], ILAC TEDAVI DERGISI
   [Anonymous], 1995, WHO EXP COMM PHYS ST
   Basoglu C, 2010, INT CLIN PSYCHOPHARM, V25, P165, DOI 10.1097/YIC.0b013e3283377850
   Belmaker RH, 2004, NEW ENGL J MED, V351, P476, DOI 10.1056/NEJMra035354
   Bernstein EE, 2015, AUST NZ J PSYCHIAT, V49, P566, DOI 10.1177/0004867414565479
   Bly MJ, 2014, BIPOLAR DISORD, V16, P277, DOI 10.1111/bdi.12160
   Bond DJ, 2017, J CLIN PSYCHIAT, V78, P441, DOI 10.4088/JCP.15m10189
   Bresciani E, 2006, J ENDOCRINOL INVEST, V29, pRC16, DOI 10.1007/BF03344175
   Cervantes P, 2001, J PSYCHIATR NEUROSCI, V26, P411
   Ehrlich S, 2012, J CLIN PSYCHOPHARM, V32, P767, DOI 10.1097/JCP.0b013e318270e5c5
   Fagiolini A, 2002, J CLIN PSYCHIAT, V63, P528, DOI 10.4088/JCP.v63n0611
   First M.B., 2016, Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version
   Goldstein BI, 2011, BIPOLAR DISORD, V13, P387, DOI 10.1111/j.1399-5618.2011.00932.x
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Ilnytska O, 2008, CELL MOL LIFE SCI, V65, P2721, DOI 10.1007/s00018-008-8104-4
   Karadag Figen, 2002, Turk Psikiyatri Derg, V13, P107
   Korbonits M, 2004, FRONT NEUROENDOCRIN, V25, P27, DOI 10.1016/j.yfrne.2004.03.002
   Maletic V, 2004, FRONT PSYCHIATRY, V5, P98
   Malhotra N, 2016, INDIAN J MED RES, V143, P434, DOI 10.4103/0971-5916.184284
   Maniam J, 2012, NEUROPHARMACOLOGY, V63, P97, DOI 10.1016/j.neuropharm.2012.04.017
   McElroy SL, 2002, J CLIN PSYCHIAT, V63, P207, DOI 10.4088/JCP.v63n0306
   McElroy SL, 2012, CURR PSYCHIAT REP, V14, P650, DOI 10.1007/s11920-012-0313-8
   McIntyre RS, 2010, J AFFECT DISORDERS, V126, P366, DOI 10.1016/j.jad.2010.04.012
   McNeilly AD, 2015, PSYCHONEUROENDOCRINO, V52, P272, DOI 10.1016/j.psyneuen.2014.12.002
   MONTGOMERY SA, 1979, BRIT J PSYCHIAT, V134, P382, DOI 10.1192/bjp.134.4.382
   Nogueiras R, 2007, ENDOCRINOLOGY, V148, P21, DOI 10.1210/en.2006-0915
   Ollmann MM, 1997, SCIENCE, V278, P135, DOI 10.1126/science.278.5335.135
   Ousova O, 2004, MOL ENDOCRINOL, V18, P1687, DOI 10.1210/me.2004-0005
   Parlak N, 2018, PSYCHIAT RES, V260, P36, DOI 10.1016/j.psychres.2017.11.018
   Seoane LM, 2006, J ENDOCRINOL INVEST, V29, pRC13, DOI 10.1007/BF03344174
   Shutter JR, 1997, GENE DEV, V11, P593, DOI 10.1101/gad.11.5.593
   Torun F, 2002, 3P PSIKIYATRI PSIKOL, V10, P319
   TSUJII S, 1989, BRAIN RES BULL, V23, P165, DOI 10.1016/0361-9230(89)90142-1
   Tunçel ÖK, 2018, NORD J PSYCHIAT, V72, P150, DOI 10.1080/08039488.2017.1402953
   Uchoa ET, 2014, J NEUROENDOCRINOL, V26, P557, DOI 10.1111/jne.12157
   Vancampfort D, 2013, AM J PSYCHIAT, V170, P265, DOI 10.1176/appi.ajp.2012.12050620
   Wang Minghan, 2005, Nutr Metab (Lond), V2, P3, DOI 10.1186/1743-7075-2-3
   Watson S, 2004, BRIT J PSYCHIAT, V184, P496, DOI 10.1192/bjp.184.6.496
   Wysokinski A, 2015, METAB BRAIN DIS, V30, P529, DOI 10.1007/s11011-014-9592-6
   Xiao EN, 2003, ENDOCRINOLOGY, V144, P1736, DOI 10.1210/en.2002-220013
   YOUNG RC, 1978, BRIT J PSYCHIAT, V133, P429, DOI 10.1192/bjp.133.5.429
   Zhang JV, 2005, SCIENCE, V310, P996, DOI 10.1126/science.1117255
NR 44
TC 5
Z9 5
U1 0
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 2475-0573
EI 2475-0581
J9 PSYCHIAT CLIN PSYCH
JI Psychiatry Clin. Psychopharmacol.
PD JAN 2
PY 2019
VL 29
IS 1
BP 14
EP 20
DI 10.1080/24750573.2018.1487649
PG 7
WC Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Psychiatry
GA HP2KT
UT WOS:000461499800003
OA gold
DA 2025-06-11
ER

PT J
AU Fenercioglu, AK
AF Fenercioglu, Aysen Kutan
TI The Anti-Inflammatory Roles of Vitamin D for Improving Human Health
SO CURRENT ISSUES IN MOLECULAR BIOLOGY
LA English
DT Review
DE vitamin D; inflammation; autoimmune disease; immune activation
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; SJOGRENS-SYNDROME; D DEFICIENCY;
   D-3; INFLAMMATION; ASSOCIATION
AB Vitamin D receptors (VDRs) are present in almost all cells of the immune system, including B cells, T cells, NK (Natural Killer) cells, dendritic cells, and monocytes, as well as the epithelial cells of many organs such as the intestine, pancreas, prostate, lungs, and cardiomyocytes. In addition, some immune cells, including dendritic cells, macrophages, and B and T cells, can synthesize calcitriol by expressing 1 alpha-hydroxylase. Upon binding to VDRs, vitamin D (Vit D) regulates the expression of genes involved in immune responses, including those encoding for cytokines. It modulates the production of pro-inflammatory cytokines while promoting the synthesis of anti-inflammatory cytokines. Vit D also affects the differentiation and maturation of cells of the immune system. By inhibiting the nuclear factor kappa B (NF-kappa B) and mitogen-activated protein kinase (MAPK) pathways, Vit D reduces the expression of pro-inflammatory genes. These effects highlight the potential of Vit D as a therapeutic agent in the management of inflammatory diseases, including autoimmune disorders, cardiovascular diseases, diabetes, metabolic syndrome, cancer, neurological diseases, depression, and inflammatory bowel disease.
C1 [Fenercioglu, Aysen Kutan] Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Dept Family Med, TR-34098 Istanbul, Turkiye.
C3 Istanbul University - Cerrahpasa
RP Fenercioglu, AK (corresponding author), Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Dept Family Med, TR-34098 Istanbul, Turkiye.
EM aysen.fenercioglu@iuc.edu.tr
RI Kutan Fenercioglu, Aysen/L-9876-2013
OI Kutan Fenercioglu, Aysen/0000-0003-2965-6102
CR Al-kuraishy HM, 2024, N-S ARCH PHARMACOL, V397, P33, DOI 10.1007/s00210-023-02656-6
   Arabi A, 2024, HELIYON, V10, DOI 10.1016/j.heliyon.2024.e35764
   Athanassiou L, 2023, BIOMOLECULES, V13, DOI 10.3390/biom13040709
   Baldini C, 2014, RHEUMATOL INT, V34, P1159, DOI 10.1007/s00296-013-2872-3
   Berridge MJ, 2017, PHARMACOL REV, V69, P80, DOI 10.1124/pr.116.013227
   Bhargava P, 2017, JCI INSIGHT, V2, DOI 10.1172/jci.insight.95302
   Bikle Daniel D, 2018, Bone Rep, V8, P255, DOI 10.1016/j.bonr.2018.02.004
   Boccuzzi L, 2023, EUR REV MED PHARMACO, V27, P4678, DOI 10.26355/eurrev_202305_32479
   Bouillon R, 2016, ENDOCRINOLOGY, V157, P3384, DOI 10.1210/en.2016-1528
   Cai F, 2022, NUTRIENTS, V14, DOI 10.3390/nu14102113
   Cantorna MT, 2011, ANN NY ACAD SCI, V1217, P77, DOI 10.1111/j.1749-6632.2010.05823.x
   Chen JJ, 2023, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.1079668
   Chen PZ, 2010, BREAST CANCER RES TR, V121, P469, DOI 10.1007/s10549-009-0593-9
   Chiu KC, 2004, AM J CLIN NUTR, V79, P820
   Condoleo V, 2021, Endocrines, V2, P417, DOI [10.3390/endocrines2040037, DOI 10.3390/ENDOCRINES2040037]
   Cui P, 2023, J NEUROINFLAMM, V20, DOI 10.1186/s12974-023-02705-0
   Ding C, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061707
   Erten S, 2015, INT J RHEUM DIS, V18, P70, DOI 10.1111/1756-185X.12298
   Eyles DW, 2013, FRONT NEUROENDOCRIN, V34, P47, DOI 10.1016/j.yfrne.2012.07.001
   Fenercioglu AK, 2023, BIOMOLECULES, V13, DOI 10.3390/biom13121778
   Ford ES, 2005, DIABETES CARE, V28, P1228, DOI 10.2337/diacare.28.5.1228
   Hadi S. T., 2021, IOP Conference Series: Earth and Environmental Science, V761, DOI 10.1088/1755-1315/761/1/012121
   Heaney R.P., 2011, Endocrine Reviews, V32, P155, DOI [10.1210/edrv.32.1.zef155, DOI 10.1210/EDRV.32.1.ZEF155]
   Hoe E, 2016, NUTRIENTS, V8, DOI 10.3390/nu8120806
   Holick MF, 2007, NEW ENGL J MED, V357, P266, DOI 10.1056/NEJMra070553
   Illescas-Montes R, 2019, LIFE SCI, V233, DOI 10.1016/j.lfs.2019.116744
   Jablonski KL, 2011, HYPERTENSION, V57, P63, DOI 10.1161/HYPERTENSIONAHA.110.160929
   Khanolkar S, 2023, CUREUS J MED SCIENCE, V15, DOI 10.7759/cureus.42470
   Kim HA, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9040327
   Krystal JH, 2002, MOL PSYCHIATR, V7, pS71, DOI 10.1038/sj.mp.4001021
   Lehmann U, 2013, J CLIN ENDOCR METAB, V98, P4339, DOI 10.1210/jc.2012-4287
   Li DY, 2019, J STEROID BIOCHEM, V187, P1, DOI 10.1016/j.jsbmb.2018.10.008
   Lima LAR, 2018, J NEUROINFLAMM, V15, DOI 10.1186/s12974-018-1266-6
   Lupoli R, 2017, J CLIN ENDOCR METAB, V102, P2146, DOI 10.1210/jc.2017-00342
   Martínez-Miguel P, 2014, AM J PHYSIOL-ENDOC M, V307, pE1085, DOI 10.1152/ajpendo.00156.2014
   Muhammad MH, 2020, EXP CLIN ENDOCR DIAB, V128, P144, DOI 10.1055/a-0934-5666
   Murdaca G, 2023, BIOMEDICINES, V11, DOI 10.3390/biomedicines11010010
   Nardin M, 2024, BIOMEDICINES, V12, DOI 10.3390/biomedicines12040768
   Oosterwerff MM, 2011, CLIN ENDOCRINOL, V75, P608, DOI 10.1111/j.1365-2265.2011.04110.x
   Pál É, 2023, NUTRIENTS, V15, DOI 10.3390/nu15020334
   Patrick RP, 2014, FASEB J, V28, P2398, DOI 10.1096/fj.13-246546
   Peixoto RD, 2022, CANCER TREAT RES COM, V32, DOI 10.1016/j.ctarc.2022.100616
   Penna G, 2000, J IMMUNOL, V164, P2405, DOI 10.4049/jimmunol.164.5.2405
   Pittas AG, 2007, J CLIN ENDOCR METAB, V92, P2017, DOI 10.1210/jc.2007-0298
   Raman Maitreyi, 2011, Therap Adv Gastroenterol, V4, P49, DOI 10.1177/1756283X10377820
   Sangha A, 2023, NUTRIENTS, V15, DOI 10.3390/nu15132978
   Sidarala V, 2016, RECENT PATENTS ENDOC, V10, P76, DOI 10.2174/1872214810666161020154905
   Siddiq A, 2023, MEDICINA-LITHUANIA, V59, DOI 10.3390/medicina59050853
   Sîrbe C, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23179784
   Sparaco M, 2024, J CLIN MED, V13, DOI 10.3390/jcm13030835
   Trasciatti Silvia, 2024, Adv Food Nutr Res, V109, P249, DOI 10.1016/bs.afnr.2023.12.004
   Tv P, 2023, CLIN NUTR ESPEN, V57, P697, DOI 10.1016/j.clnesp.2023.08.025
   von Hurst PR, 2010, BRIT J NUTR, V103, P549, DOI 10.1017/S0007114509992017
   Vyas N, 2016, WORLD J GASTRO ONCOL, V8, P688, DOI 10.4251/wjgo.v8.i9.688
   Wang WX, 2023, HELIYON, V9, DOI 10.1016/j.heliyon.2023.e12877
   Wassif GA, 2023, CUREUS J MED SCIENCE, V15, DOI 10.7759/cureus.47716
   Wolf D, 2019, CIRC RES, V124, P315, DOI 10.1161/CIRCRESAHA.118.313591
   Zhang ML, 2017, CLIN CHIM ACTA, V468, P152, DOI 10.1016/j.cca.2017.02.022
   Zhang ZS, 2024, HELIYON, V10, DOI 10.1016/j.heliyon.2023.e23674
NR 59
TC 11
Z9 11
U1 7
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1467-3037
EI 1467-3045
J9 CURR ISSUES MOL BIOL
JI Curr. Issues Mol. Biol.
PD DEC
PY 2024
VL 46
IS 12
BP 13514
EP 13525
DI 10.3390/cimb46120807
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA Q3O6S
UT WOS:001383822800001
PM 39727935
OA gold
DA 2025-06-11
ER

PT J
AU Bytyçi, I
   Bengrid, TM
   Henein, MY
AF Bytyci, Ibadete
   Bengrid, Tarek M.
   Henein, Michael Y.
TI Longitudinal myocardial function is more compromised in cardiac syndrome
   X compared to insignificant CAD: Role of stress echocardiography and
   calcium scoring
SO CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING
LA English
DT Article
DE cardiac syndrome X; coronary artery calcium score; dobutamine stress
   echocardiography; insignificant coronary artery disease
ID CORONARY-ARTERY-DISEASE; LONG-AXIS FUNCTION; DOBUTAMINE STRESS; EUROPEAN
   ASSOCIATION; COMPUTED-TOMOGRAPHY; NATURAL-HISTORY; ANGINA-PECTORIS;
   STABLE ANGINA; CALCIFICATION; ANGIOGRAPHY
AB Background and Aim The aim of this study was to assess the nature of myocardial dysfunction in the cardiac syndrome X (CSX) and insignificant coronary artery disease (ICAD) using dobutamine stress echocardiography (DSE) and coronary calcium scoring (CAC). Methods We prospectively studied 35 consecutive patients who complained of exertional angina, had >= 1 mm ST shift on exercise stress test but normal or no obstructive CAD (<50%) on angiography. Patients were divided into CSX (n = 27) with normal arteries and ICAD (n = 8) with insignificant stenosis. Results CSX patients had more females, lower calcium score and less prevalent cardiac risk factors compared to ICAD (p < 0.05 for all). At peak stress, MAPSE and TAPSE failed to increase in both groups. LV septal and lateral s' increased in the two groups but the increment increase was less in CSX than ICAD (p < 0.05) while other diastolic indices did not differ between groups (p > 0.05 for all). CAC correlated modestly with LV and RV systolic velocities: septal s' (r = -0.65, p < 0.001) lateral s' (r = -0.35, p = 0.04) and right s' (r = -0.53, p = 0.005) in CSX, while in ICAD patients only with RV s' (r = -0.58, p = 0.02). On multivariate model, only septal s' OR 1.816 (1.1090-3.820, p = 0.04) proved the most powerful independent predictor of CAC. Conclusions Compromised LV longitudinal systolic velocities were more pronounced and calcium score as a surrogate for atherosclerosis was lower in CSX than ICAD. These findings strengthen the evidence for different pathogenesis of CSX compared to ICAD, with microvascular disease in the former and calcification in the latter.
C1 [Bytyci, Ibadete; Henein, Michael Y.] Umea Univ, Inst Publ Hlth & Clin Med, S-90187 Umea, Sweden.
   [Bytyci, Ibadete] Univ Clin Ctr Kosovo, Clin Cardiol, Prishtina 10000, Kosovo.
   [Bengrid, Tarek M.] Tripoli Univ, Tripoli 13275, Libya.
   [Henein, Michael Y.] London & Brunel Univ, Mol & Clin Res Inst, St George Univ, London UB8 3PH, England.
C3 Umea University; Universiteti i Prishtines; University of Tripoli; City
   St Georges, University of London; St Georges University London
RP Henein, MY (corresponding author), Umea Univ, Inst Publ Hlth & Clin Med, S-90187 Umea, Sweden.
EM michael.henein@umu.se
RI Bytyçi, Ibadete/L-1767-2018
OI Bytyci, Ibadete/0000-0002-8996-4257
CR Agrawal S, 2014, CARDIOL CLIN, V32, P463, DOI 10.1016/j.ccl.2014.04.006
   Bengrid T, 2013, INT J CARDIOL, V168, P1697, DOI 10.1016/j.ijcard.2013.03.071
   Bluemke DA, 2008, CIRCULATION, V118, P586, DOI 10.1161/CIRCULATIONAHA.108.189695
   Camici PG, 2007, NEW ENGL J MED, V356, P830, DOI 10.1056/NEJMra061889
   Chen QM, 2004, INT J CARDIOL, V97, P289, DOI 10.1016/j.ijcard.2004.03.048
   Crea F, 2004, HEART, V90, P457, DOI 10.1136/hrt.2003.020594
   Di Fiore DP, 2013, INT J EVID-BASED HEA, V11, P56, DOI 10.1111/1744-1609.12002
   Duncan AM, 2003, CIRCULATION, V108, P1214, DOI 10.1161/01.CIR.0000087401.19332.B7
   Elfigih IA, 2014, IJC HEART VASC, V5, P51, DOI 10.1016/j.ijcha.2014.10.008
   Frimpong GAA, 2018, VASC HEALTH RISK MAN, V14, P75, DOI 10.2147/VHRM.S160669
   Hecht HS, 2017, J CARDIOVASC COMPUT, V11, P74, DOI 10.1016/j.jcct.2016.11.003
   Henein MY, 2017, IJC HEART VASC, V14, P41, DOI 10.1016/j.ijcha.2016.12.001
   Henein MY, 2013, INT J CARDIOL, V168, P3944, DOI 10.1016/j.ijcard.2013.06.057
   HENEIN MY, 1994, BRIT HEART J, V71, P541
   HENEIN MY, 1993, BRIT HEART J, V69, P409
   Herscovici R, 2018, J AM HEART ASSOC, V7, DOI 10.1161/JAHA.118.008868
   Hoffmann S, 2011, EUR J ECHOCARDIOGR, V12, P628, DOI 10.1093/ejechocard/jer094
   Jespersen L, 2012, EUR HEART J, V33, P734, DOI 10.1093/eurheartj/ehr331
   Knuuti J, 2020, EUR HEART J, V41, P407, DOI 10.1093/eurheartj/ehz425
   Lang RM, 2015, EUR HEART J-CARD IMG, V16, P233, DOI 10.1093/ehjci/jev014
   Mattoso AAA, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0172280
   Melikian N, 2008, PROG CARDIOVASC DIS, V50, P294, DOI 10.1016/j.pcad.2007.01.003
   Metz LD, 2007, J AM COLL CARDIOL, V49, P227, DOI 10.1016/j.jacc.2006.08.048
   NAKANO K, 1989, CIRC RES, V65, P1555, DOI 10.1161/01.RES.65.6.1555
   O'Sullivan CA, 2005, AM J CARDIOL, V96, P622, DOI 10.1016/j.amjcard.2005.04.031
   OLSON CE, 1994, J AM COLL CARDIOL, V24, P1268, DOI 10.1016/0735-1097(94)90108-2
   Palmerini E, 2015, IJC HEART VASC, V9, P109, DOI 10.1016/j.ijchv.2014.07.002
   Pargaonkar VS, 2020, INT J CARDIOL, V311, P107, DOI 10.1016/j.ijcard.2020.02.006
   Pargaonkar VS, 2020, INT J CARDIOL, V309, P8, DOI 10.1016/j.ijcard.2020.02.014
   Patel Manesh R, 2010, N Engl J Med, V362, P886, DOI 10.1056/NEJMoa0907272
   Pellikka PA, 2020, J AM SOC ECHOCARDIOG, V33, P1, DOI 10.1016/j.echo.2019.07.001
   Pizzi C, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.116.004185
   Russo G, 2013, CARDIOVASC DRUG THER, V27, P229, DOI 10.1007/s10557-013-6439-z
   Sedlak TL, 2013, AM HEART J, V166, P38, DOI 10.1016/j.ahj.2013.03.015
   Sicari R, 2008, EUR J ECHOCARDIOGR, V9, P415, DOI 10.1093/ejechocard/jen175
   Sikharulidze I, 2020, Georgian Med News, P43
   Tavella R, 2016, EUR HEART J-QUAL CAR, V2, P117, DOI 10.1093/ehjqcco/qcv034
   Vancheri F, 2019, DIAGNOSTICS, V9, DOI 10.3390/diagnostics9040125
NR 38
TC 2
Z9 2
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1475-0961
EI 1475-097X
J9 CLIN PHYSIOL FUNCT I
JI Clin. Physiol. Funct. Imaging
PD JAN
PY 2022
VL 42
IS 1
BP 35
EP 42
DI 10.1111/cpf.12733
EA NOV 2021
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA YC1EP
UT WOS:000717917800001
PM 34716983
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Freese, EC
   Acitelli, RM
   Gist, NH
   Cureton, KJ
   Evans, EM
   O'Connor, PJ
AF Freese, Eric C.
   Acitelli, Rachelle M.
   Gist, Nicholas H.
   Cureton, Kirk J.
   Evans, Ellen M.
   O'Connor, Patrick J.
TI Effect of Six Weeks of Sprint Interval Training on Mood and Perceived
   Health in Women at Risk for Metabolic Syndrome
SO JOURNAL OF SPORT & EXERCISE PSYCHOLOGY
LA English
DT Article
DE exercise psychology; exercise training; health behavior
ID QUALITY-OF-LIFE; POSTPRANDIAL LIPEMIA; PHYSICAL-ACTIVITY; EXERCISE;
   ADAPTATIONS; SYMPTOMS; CAPACITY; MUSCLE; PERFORMANCE; DEPRESSION
AB The purpose of this investigation was to determine whether 6 weeks of sprint interval training (SIT) is associated with changes in mood and perceived health in women at risk for developing metabolic syndrome (MetS). Physically inactive women (30-65 years) were randomized to 6 weeks of nutrition meetings and SIT (n = 23; 3 bouts/week of 4-8 30-s cycle sprints with 4-mM recovery) or a nonexercise control condition (CON; n = 24). Before and after the 6-week intervention, perceived health status and mood were assessed. Clinically relevant increases in role-physical scores (ES = 0.64) and vitality (ES = 0.52) were found after 6 weeks of SIT compared with a nonexercise control group. For middle-aged women at risk for MetS, it is concluded that high-intensity, low-volume SIT (1) increases feelings of vitality and perceptions of having fewer physical limitations and (2) does not induce mood disturbances as occurs with high-volume, high-intensity training.
C1 [Freese, Eric C.; Acitelli, Rachelle M.; Gist, Nicholas H.; Cureton, Kirk J.; Evans, Ellen M.; O'Connor, Patrick J.] Univ Georgia, Dept Kinesiol, Athens, GA 30602 USA.
   [Gist, Nicholas H.] US Mil Acad, Dept Phys Educ, West Point, NY 10996 USA.
C3 University System of Georgia; University of Georgia; United States
   Department of Defense; United States Army; United States Military
   Academy
RP Freese, EC (corresponding author), Univ Georgia, Dept Kinesiol, Athens, GA 30602 USA.
EM efreese2@gmail.com
RI O'Connor, Patrick/HII-2987-2022
OI Cureton, Kirk/0000-0003-4917-6587
FU Egg Nutrition Center
FX The authors thank Jeremy Dean, Sasha McBurse, and Chad Straight for
   their assistance with the exercise training and Catherine Beck and
   Whitni McConnell for their weight maintenance and dietary guidance. In
   addition, the authors thank the undergraduate research assistants in the
   Department of Kinesiology, especially Sara Dover and Rachel Butler, for
   their assistance with testing, data entry, and supervising exercise
   training sessions. This randomized clinical trial was supported by the
   Egg Nutrition Center. The authors declare no conflicts of interest.
CR [Anonymous], 2000, Qual. Life Res.
   [Anonymous], 2009, National health statistics reports
   [Anonymous], THESIS U PITTSBURGH
   Bize R, 2007, PREV MED, V45, P401, DOI 10.1016/j.ypmed.2007.07.017
   Burgomaster KA, 2005, J APPL PHYSIOL, V98, P1985, DOI 10.1152/japplphysiol.01095.2004
   Burgomaster KA, 2008, J PHYSIOL-LONDON, V586, P151, DOI 10.1113/jphysiol.2007.142109
   Cotman CW, 2007, TRENDS NEUROSCI, V30, P464, DOI 10.1016/j.tins.2007.06.011
   Freese EC, 2014, J APPL PHYSIOL, V116, P67, DOI 10.1152/japplphysiol.00623.2013
   Freese EC, 2013, J STRENGTH COND RES, V27, P2768, DOI 10.1519/JSC.0b013e318281575c
   Freese EC, 2011, J APPL PHYSIOL, V111, P1584, DOI 10.1152/japplphysiol.00416.2011
   Gardner AW, 2006, J VASC SURG, V43, P1191, DOI 10.1016/j.jvs.2006.02.042
   Gibala MJ, 2008, EXERC SPORT SCI REV, V36, P58, DOI 10.1097/JES.0b013e318168ec1f
   Gibala MJ, 2006, J PHYSIOL-LONDON, V575, P901, DOI 10.1113/jphysiol.2006.112094
   Gist NH, 2014, SPORTS MED, V44, P269, DOI 10.1007/s40279-013-0115-0
   Grundy SM, 2006, CURR OPIN CARDIOL, V21, P1, DOI 10.1097/01.hco.0000200416.65370.a0
   Herring MP, 2012, ARCH INTERN MED, V172, P101, DOI 10.1001/archinternmed.2011.696
   Herring MP, 2010, ARCH INTERN MED, V170, P321, DOI 10.1001/archinternmed.2009.530
   IDLER EL, 1991, J GERONTOL, V46, pS55, DOI 10.1093/geronj/46.2.S55
   Laforge RG, 1999, PREV MED, V28, P349, DOI 10.1006/pmed.1998.0429
   Lehto SM, 2008, ANN EPIDEMIOL, V18, P871, DOI 10.1016/j.annepidem.2008.07.005
   Little JP, 2011, J APPL PHYSIOL, V111, P1554, DOI 10.1152/japplphysiol.00921.2011
   Loy BD, 2013, FATIGUE, V1, P223, DOI 10.1080/21641846.2013.843266
   McNair DM, 1992, Manual for the profile of mood states
   Norman GR, 2003, MED CARE, V41, P582, DOI 10.1097/00005650-200305000-00004
   O'Connor PJ, 2007, SPORTS MED, V37, P408, DOI 10.2165/00007256-200737040-00035
   Puetz TW, 2006, PSYCHOL BULL, V132, P866, DOI 10.1037/0033-2909.132.6.866
   Reed J, 2009, PSYCHOL SPORT EXERC, V10, P581, DOI 10.1016/j.psychsport.2009.05.009
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   STEWART AL, 1994, J CLIN EPIDEMIOL, V47, P719, DOI 10.1016/0895-4356(94)90169-4
   Trilk JL, 2011, EUR J APPL PHYSIOL, V111, P1591, DOI 10.1007/s00421-010-1777-z
   WARE JE, 1992, MED CARE, V30, P473, DOI 10.1097/00005650-199206000-00002
NR 31
TC 19
Z9 23
U1 0
U2 26
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 0895-2779
EI 1543-2904
J9 J SPORT EXERCISE PSY
JI J. Sport Exerc. Psychol.
PD DEC
PY 2014
VL 36
IS 6
BP 610
EP 618
DI 10.1123/jsep.2014-0083
PG 9
WC Hospitality, Leisure, Sport & Tourism; Psychology, Applied; Psychology;
   Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Social Sciences - Other Topics; Psychology; Sport Sciences
GA AZ8UY
UT WOS:000348491000006
PM 25602143
DA 2025-06-11
ER

PT J
AU Abu-Zaid, A
   Baradwan, S
   Bukhari, IA
   Alyousef, A
   Abuzaid, M
   Saleh, SAK
   Adly, HM
   Alomar, O
   Al-Badawi, IA
AF Abu-Zaid, Ahmed
   Baradwan, Saeed
   Bukhari, Ibtihal Abdulaziz
   Alyousef, Abdullah
   Abuzaid, Mohammed
   Saleh, Saleh A. K.
   Adly, Heba M.
   Alomar, Osama
   Al-Badawi, Ismail Abdulrahman
TI The effect of alpha-lipoic acid supplementation on anthropometric,
   glycemic, lipid, oxidative stress, and hormonal parameters in
   individuals with polycystic ovary syndrome: a systematic review and
   meta-analysis of randomized clinical trials
SO OBSTETRICS & GYNECOLOGY SCIENCE
LA English
DT Review
DE Thioctic acid; Inositol; Polycystic ovary syndrome; Cardiometabolic risk
   factors
ID INSULIN SENSITIVITY; SIGNALING PATHWAY; QUALITY; WOMEN; ALA
AB This systematic review and meta-analysis aimed to examine the effect of the antioxidant alpha-lipoic acid (ALA) on various cardiometabolic risk factors and hormonal parameters in patients with polycystic ovary syndrome (PCOS). We searched PubMed, EMBASE, SCOPUS, Cochrane Library, and Web of Science databases without language restrictions until May 2023 to find randomized controlled trials (RCTs) that assessed the impact of ALA supplementation on anthropometric, glycemic, lipid, oxidative stress, and hormonal parameters in women with PCOS. Outcomes were summarized using the standardized mean difference (SMD) and 95% confidence interval (CI) in a random-effects model. An I2 statistic of >60% established significant between-study heterogeneity. The overall certainty of the evidence for each outcome was determined using the grading of recommendations, assessment, development, and evaluations system. Seven RCTs met the inclusion criteria. The ALA group had significant reductions in fasting blood sugar (fasting blood sugar (FBS), n=7 RCTs, SMD,-0.60; 95% CI,-1.10 to-0.10; I-2=63.54%, moderate certainty of evidence) and homeostatic model assessment for insulin resistance (homeostatic model assessment of insulin resistance (HOMA-IR), n=4 RCTs, SMD,-2.03; 95% CI,-3.85 to-0.20; I-2=96.32%, low certainty of evidence) compared with the control group. However, significant differences were observed between the groups in body mass index, insulin, estrogen, follicle-stimulating hormone, luteinizing hormone, testosterone, low-density lipoprotein, high density lipoprotein, triglyceride, total cholesterol, malondialdehyde, or total antioxidant capacity profiles. ALA supplementation improves FBS and HOMA-IR levels in women with PCOS. ALA consumption is an effective complementary therapy for the management of women with PCOS.
C1 [Abu-Zaid, Ahmed; Alomar, Osama; Al-Badawi, Ismail Abdulrahman] Alfaisal Univ, Coll Med, Dept Obstet & Gynecol, Al Zahrawi St, Riyadh 11533, Saudi Arabia.
   [Baradwan, Saeed] King Faisal Specialist Hosp & Res Ctr, Dept Obstet & Gynecol, Jeddah, Saudi Arabia.
   [Bukhari, Ibtihal Abdulaziz] Princess Nourah Bint Abdulrahman Univ, Coll Med, Dept Obstet & Gynecol, Riyadh, Saudi Arabia.
   [Alyousef, Abdullah] King Abdullah Bin Abdulaziz Univ Hosp, Dept Obstet & Gynecol, Riyadh, Saudi Arabia.
   [Abuzaid, Mohammed] Muhayil Gen Hosp, Dept Obstet & Gynecol, Muhayil, Saudi Arabia.
   [Saleh, Saleh A. K.] Umm Al Qura Univ, Fac Med, Dept Biochem, Mecca, Saudi Arabia.
   [Saleh, Saleh A. K.] Ain Shams Univ, Fac Med, Oncol Diagnost Unit, Cairo, Egypt.
   [Adly, Heba M.] Umm Al Qura Univ, Fac Med, Dept Community Med & Pilgrims Healthcare, Mecca, Saudi Arabia.
   [Alomar, Osama; Al-Badawi, Ismail Abdulrahman] King Faisal Specialist Hosp & Res Ctr, Dept Obstet & Gynecol, Riyadh, Saudi Arabia.
C3 King Faisal Specialist Hospital & Research Center; Princess Nourah bint
   Abdulrahman University; Umm Al-Qura University; Egyptian Knowledge Bank
   (EKB); Ain Shams University; Umm Al-Qura University; King Faisal
   Specialist Hospital & Research Center
RP Abu-Zaid, A (corresponding author), Alfaisal Univ, Coll Med, Dept Obstet & Gynecol, Al Zahrawi St, Riyadh 11533, Saudi Arabia.
EM aabuzaid@live.com
RI Saleh, Saleh/S-6837-2019; Adly, Prof Heba/IQU-8083-2023; Azzam,
   Ahmed/ITT-4117-2023; Baradwan, Saeed/I-3387-2019; bukhari,
   ibtihal/JQJ-5131-2023
OI Abu-Zaid, Ahmed/0000-0003-2286-2181; Alomar, Osama/0000-0003-4715-9396;
   Saleh, Saleh Ahmed/0000-0001-9522-9198
CR Manal A, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-02120-6
   Aiassa V, 2022, FOOD RES INT, V156, DOI 10.1016/j.foodres.2022.111164
   Asa E, 2020, Qom Univ Med Sci J, V14, P49
   Capece U, 2023, NUTRIENTS, V15, DOI 10.3390/nu15010018
   Cianci A, 2015, GYNECOL ENDOCRINOL, V31, P483, DOI 10.3109/09513590.2015.1014784
   Costantini D, 2019, J EXP BIOL, V222, DOI 10.1242/jeb.194688
   Diane A, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-77621-x
   Dugbartey GJ, 2022, DIABETOL METAB SYNDR, V14, DOI 10.1186/s13098-022-00921-x
   Elbadawy AM, 2021, ALEX J MED, V57, P113, DOI 10.1080/20905068.2021.1907961
   Fogacci F, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9101011
   Fruzzetti F, 2020, INT J ENDOCRINOL, V2020, DOI 10.1155/2020/2901393
   Glintborg D., 2020, Current Opinion in Endocrine and Metabolic Research, V12, P33, DOI [10.1016/j.coemr.2020.02.014, DOI 10.1016/J.COEMR.2020.02.014]
   Guyatt GH, 2008, BRIT MED J, V336, P924, DOI 10.1136/bmj.39489.470347.AD
   Hamed BM, 2023, Egyptian J Hosp Med, V90, P2728
   Heshmati J, 2021, J FOOD BIOCHEM, V45, DOI 10.1111/jfbc.13543
   Higgins J. P. T., 2019, Cochrane Handbook for Systematic Reviews of Interventions, V2nd
   Ivanova LA, 2015, Open J Endocr Metab Dis, V5, P37
   JACOB S, 1995, ARZNEIMITTEL-FORSCH, V45-2, P872
   Jannatifar R, 2022, ANAT CELL BIOL, V55, P239, DOI 10.5115/acb.21.242
   Joham AE, 2022, LANCET DIABETES ENDO, V10, P668, DOI 10.1016/S2213-8587(22)00163-2
   Karimi E, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-01244-4
   Kaviyani N, Research Square, Vc2020, DOI [10.21203/rs.3.rs-37045/v1, DOI 10.21203/RS.3.RS-37045/V1]
   Kim MS, 2004, NAT MED, V10, P727, DOI 10.1038/nm1061
   Kra G, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-32433-7
   Kucukgoncu S, 2017, OBES REV, V18, P594, DOI 10.1111/obr.12528
   Laganà AS, 2022, EUR REV MED PHARMACO, V26, P1241, DOI 10.26355/eurrev_202202_28116
   Lee SJ, 2011, HORM METAB RES, V43, P445, DOI 10.1055/s-0031-1277182
   Lee WJ, 2005, BIOCHEM BIOPH RES CO, V332, P885, DOI 10.1016/j.bbrc.2005.05.035
   Louwers YV, 2020, THER ADV REPROD HEAL, V14, DOI 10.1177/2633494120911038
   Maciejczyk M, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/7450514
   Mahmoudi-Nezhad M, 2021, NUTRITION, V82, DOI 10.1016/j.nut.2020.111041
   Mohammadi V, 2018, INT J PREVENTIVE MED, V9, DOI 10.4103/ijpvm.IJPVM_32_17
   Mohammed MA, 2019, STEROIDS, V144, P1, DOI 10.1016/j.steroids.2019.01.004
   Moher D, 2016, REV ESP NUTR HUM DIE, V20, P148, DOI 10.14306/renhyd.20.2.223
   Moradi N, 2021, OBSTET GYNECOL SCI, V64, P274, DOI 10.5468/ogs.20094
   Najafi N, 2022, PHYTOTHER RES, V36, P2300, DOI 10.1002/ptr.7406
   Namazi N, 2018, CLIN NUTR, V37, P419, DOI 10.1016/j.clnu.2017.06.002
   Naz MSG, 2019, INT J REPROD BIOMED, V17, P533, DOI 10.18502/ijrm.v17i8.4818
   Pakniat H, 2020, OBSTET GYNECOL SCI, V63, P173, DOI 10.5468/ogs.2020.63.2.173
   Park KG, 2008, Hepatology
   Rago R, 2015, J BIOL REG HOMEOS AG, V29, P913
   Rahimlou M, 2019, CLIN NUTR ESPEN, V32, P16, DOI 10.1016/j.clnesp.2019.03.015
   Riestenberg C, 2022, J CLIN ENDOCR METAB, V107, P575, DOI 10.1210/clinem/dgab613
   Romualdi D, 2020, THER ADV REPROD HEAL, V14, DOI 10.1177/2633494120908709
   Salehpour S, 2019, J BRAS REPROD ASSIST, V23, P235, DOI 10.5935/1518-0557.20190032
   Sandhu JK, 2021, CUREUS J MED SCIENCE, V13, DOI 10.7759/cureus.17887
   Shan HY, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.904942
   Vajdi M, 2020, INT J CLIN PRACT, V74, DOI 10.1111/ijcp.13493
   Zeng MQ, 2021, REDOX BIOL, V41, DOI 10.1016/j.redox.2021.101948
   Zonooz SR, 2021, J FUNCT FOODS, V87, DOI 10.1016/j.jff.2021.104774
NR 50
TC 3
Z9 3
U1 3
U2 6
PU Korean Soc Obstetrics and Gynecology (KSOG)
PI Seoul
PA 4th Floor, 36 Gangnam-daero 132-gil, Gangnam-gu, Seoul, SOUTH KOREA
SN 2287-8572
EI 2287-8580
J9 OBSTET GYNECOL SCI
JI Obstet. Gynecol. Sci.
PD JAN
PY 2024
VL 67
IS 1
BP 17
EP 29
DI 10.5468/ogs.23206
PG 13
WC Obstetrics & Gynecology
WE Emerging Sources Citation Index (ESCI)
SC Obstetrics & Gynecology
GA IF9D2
UT WOS:001165022800007
PM 38044616
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Reid, BM
   Harbin, MM
   Arend, JL
   Kelly, AS
   Dengel, DR
   Gunnar, MR
AF Reid, Brie M.
   Harbin, Michelle M.
   Arend, Jessica L.
   Kelly, Aaron S.
   Dengel, Donald R.
   Gunnar, Megan R.
TI Early Life Adversity with Height Stunting Is Associated with
   Cardiometabolic Risk in Adolescents Independent of Body Mass Index
SO JOURNAL OF PEDIATRICS
LA English
DT Article
ID PULSE-WAVE VELOCITY; HEART-RATE-VARIABILITY; ARTERIAL STIFFNESS;
   PROGNOSTIC VALUE; ENDOTHELIAL FUNCTION; AUGMENTATION INDEX; COMFORT
   FOODS; CHILDHOOD; STRESS; OBESITY
AB Objective To evaluate cardiovascular and metabolic function in youths adopted internationally from orphanages/institutions (postinstitutionalized) who were height-stunted at adoption.
   Study design A total of 30 postinstitutionalized youths (age, 9-18 years: body mass index [BMI] percentile, 7.2-90.4) who were height-stunted at adoption were compared with age- and BMI percentile-matched youths (n = 90). Measurements included total body fat and visceral adipose tissue (dual radiograph absorptiometry), arterial stiffness (augmentation index and pulse wave velocity), cardiac autonomic function (heart rate variability), blood pressure, and fasting lipid, glucose, and insulin levels. Linear regression analyses were computed controlling for parent education. age, trunk tissue fat, height-for-age, sex, and race.
   Results Compared with controls of the same age. sex. and BMI, the postinstitutionalized children had higher systolic blood pressure (P = .018), augmentation index (P = .033). total cholesterol (P = .047), low-density lipoprotein cholesterol (P = .03), triglycerides (P = .048), insulin (P = .005). and HOMA-IR (P= .01) values. The postinstitutionalized children had a lower low-frequency to high-frequency ratio (P= .008), indicating lower sympathetic tone. as well as a lower total lean mass (P= .016), a lower gynoid lean mass (P= .039), and a higher proportion of trunk tissue fat (P= .017). The postinstitutionalized and control children did not differ in any other body composition measures.
   Conclusions Early life stress, as represented by height-stunted growth in institutional care. may be associated with early pathways to cardiovascular and metabolic risk in youths even after moving into well-resourced homes early in life and in the absence of increased adiposity. These findings suggest that postinstitutionalized youths with a history of height stunting may need to be closely monitored for emergent cardiometabolic risk factors.
C1 [Reid, Brie M.; Arend, Jessica L.; Gunnar, Megan R.] Univ Minnesota, Inst Child Dev, 51 E River Rd, Minneapolis, MN 55455 USA.
   [Harbin, Michelle M.; Dengel, Donald R.] Univ Minnesota, Sch Kinesiol, Minneapolis, MN 55455 USA.
   [Arend, Jessica L.] Univ Minnesota, Med Sch, Dept Psychiat, Minneapolis, MN 55455 USA.
   [Kelly, Aaron S.; Dengel, Donald R.] Univ Minnesota, Med Sch, Dept Pediat, Ctr Pediat Obes Med, Minneapolis, MN 55455 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities
RP Reid, BM (corresponding author), Univ Minnesota, Inst Child Dev, 51 E River Rd, Minneapolis, MN 55455 USA.
EM reidx189@umn.edu
RI Reid, Brie/ABC-9782-2020
OI Dengel, Donald/0000-0001-9049-7548
FU National Heart, Lung, and Blood Institute [R01 HL110957]; National
   Center for Advancing Translational Sciences [UL1TR000114]; National
   Institute of Diabetes and Digestive and Kidney Diseases (NORC Grant)
   [P30 DK050456]; Canadian Institute for Advanced Research Child and Brain
   Development program; National Science Foundation Graduate Research
   Fellowship [00039202]
FX Funded by the National Heart, Lung, and Blood Institute (R01 HL110957,
   to A.K.), the National Center for Advancing Translational Sciences
   (UL1TR000114), the National Institute of Diabetes and Digestive and
   Kidney Diseases (NORC Grant P30 DK050456), and the Canadian Institute
   for Advanced Research Child and Brain Development program (to M.G.). The
   content is solely the responsibility of the authors and does not
   necessarily represent the official views of the National Institutes of
   Health. This material is based on work supported by the National Science
   Foundation Graduate Research Fellowship (Grant 00039202, to B.R.). Any
   opinion, findings, and conclusions or recommendations expressed in this
   material are those of the authors(s) and do not necessarily reflect the
   views of the National Science Foundation. A.K. serves as a consultant
   for Novo Nordisk, Orexigen, and Vivus Pharmaceuticals and receives
   research support from Astra Zeneca Pharmaceuticals in the form of
   drug/placebo. D.D. serves as a paid consultant for Hologic, Inc. The
   other authors declare no conflicts of interest.
CR Abhishekh HA, 2013, J CLIN MONIT COMPUT, V27, P259, DOI 10.1007/s10877-012-9424-3
   Arce M, 2010, PHYSIOL BEHAV, V101, P446, DOI 10.1016/j.physbeh.2010.07.010
   Bosch TA, 2015, OBESITY, V23, P375, DOI 10.1002/oby.20961
   Bosch TA, 2014, J STRENGTH COND RES, V28, P3313, DOI 10.1519/JSC.0000000000000650
   Camm AJ, 1996, EUR HEART J, V17, P354
   Dallman MF, 2010, TRENDS ENDOCRIN MET, V21, P159, DOI 10.1016/j.tem.2009.10.004
   Dallman MF, 2005, BRAIN BEHAV IMMUN, V19, P275, DOI 10.1016/j.bbi.2004.11.004
   Danese A, 2012, PHYSIOL BEHAV, V106, P29, DOI 10.1016/j.physbeh.2011.08.019
   de Onis M, 2016, MATERN CHILD NUTR, V12, P12, DOI 10.1111/mcn.12231
   Demerath EW, 2006, PEDIATRICS, V117, pE487, DOI 10.1542/peds.2005-0572
   Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents, 2011, Pediatrics, V128 Suppl 5, pS213, DOI 10.1542/peds.2009-2107C
   Farah BQ, 2014, J PEDIATR-US, V165, P945, DOI 10.1016/j.jpeds.2014.06.065
   Fernandez-Twinn DS, 2006, PHYSIOL BEHAV, V88, P234, DOI 10.1016/j.physbeh.2006.05.039
   Gooding HC, 2016, J PEDIATR PSYCHOL, V41, P5, DOI 10.1093/jpepsy/jsv040
   Halcox JPJ, 2002, CIRCULATION, V106, P653, DOI 10.1161/01.CIR.0000025404.78001.D8
   Halcox JPJ, 2009, CIRCULATION, V119, P1005, DOI 10.1161/CIRCULATIONAHA.108.765701
   Hellerstedt WL, 2008, MATERN CHILD HLTH J, V12, P162, DOI 10.1007/s10995-007-0237-9
   Hoffman DJ, 2007, NUTRITION, V23, P640, DOI 10.1016/j.nut.2007.06.006
   Jacobs E, 2010, CHILD PSYCHIAT HUM D, V41, P15, DOI 10.1007/s10578-009-0149-6
   Johnson DE, 2011, MONOGR SOC RES CHILD, V76, P92, DOI 10.1111/j.1540-5834.2011.00629.x
   Johnson DE, 2000, MINN SYM CHILD PSYCH, V31, P113
   Kaufman CL, 2007, CLIN AUTON RES, V17, P165, DOI 10.1007/s10286-007-0411-6
   Kaul S, 2012, OBESITY, V20, P1313, DOI 10.1038/oby.2011.393
   Kelly AS, 2014, J PEDIATR-US, V165, P755, DOI 10.1016/j.jpeds.2014.05.043
   Kelly RP, 2001, HYPERTENSION, V37, P1429, DOI 10.1161/01.HYP.37.6.1429
   Kumar S, 2017, MAYO CLIN PROC, V92, P251, DOI 10.1016/j.mayocp.2016.09.017
   Kurtoglu Selim, 2010, J Clin Res Pediatr Endocrinol, V2, P100, DOI 10.4274/jcrpe.v2i3.100
   Lehman BJ, 2005, PSYCHOSOM MED, V67, P846, DOI 10.1097/01.psy.0000188443.48405.eb
   Levy J, 1999, AM J PHYSIOL-ENDOC M, V276, pE365, DOI 10.1152/ajpendo.1999.276.2.E365
   Machado TD, 2016, STRESS, V19, P287, DOI 10.1080/10253890.2016.1191464
   Machado TD, 2013, STRESS, V16, P549, DOI 10.3109/10253890.2013.816841
   Malliani A, 1997, CIRCULATION, V96, P4143
   McEwen BS, 1999, ANN NY ACAD SCI, V896, P30, DOI 10.1111/j.1749-6632.1999.tb08103.x
   McLaughlin KA, 2015, P NATL ACAD SCI USA, V112, P5637, DOI 10.1073/pnas.1423363112
   Michopoulos V, 2012, PSYCHONEUROENDOCRINO, V37, P1479, DOI 10.1016/j.psyneuen.2012.02.002
   Millasseau SC, 2005, HYPERTENSION, V45, P222, DOI 10.1161/01.HYP.0000154229.97341.d2
   Monteiro POA, 2005, OBES REV, V6, P143, DOI 10.1111/j.1467-789X.2005.00183.x
   Natl High Blood Pressure Educ Prog, 2004, PEDIATRICS, V114, P555
   Pretty C, 2013, BMC PEDIATR, V13, DOI 10.1186/1471-2431-13-208
   Rajzer MW, 2008, J HYPERTENS, V26, P2001, DOI 10.1097/HJH.0b013e32830a4a25
   Reid BM, 2017, PEDIATR RES, V82, P278, DOI 10.1038/pr.2017.35
   Riggio S, 2010, EUR J CLIN INVEST, V40, P250, DOI 10.1111/j.1365-2362.2010.02260.x
   Rubinshtein R, 2010, EUR HEART J, V31, P1142, DOI 10.1093/eurheartj/ehq010
   Ryder JR, 2016, PEDIATR RES, V79, P49, DOI 10.1038/pr.2015.188
   Sawaya Ana Lydia, 2003, Cad. Saúde Pública, V19, pS21, DOI 10.1590/S0102-311X2003000700003
   Schindler TH, 2003, ARTERIOSCL THROM VAS, V23, P495, DOI 10.1161/01.ATV.0000057571.03012.F4
   Skidmore PML, 2009, AM J CLIN NUTR, V90, P401, DOI 10.3945/ajcn.2008.27269
   Stevens GA, 2012, LANCET, V380, P824, DOI 10.1016/S0140-6736(12)60647-3
   Sutton-Tyrrell K, 2005, CIRCULATION, V111, P3384, DOI 10.1161/CIRCULATIONAHA.104.483628
   Taylor SE, 2010, P NATL ACAD SCI USA, V107, P8507, DOI 10.1073/pnas.1003890107
   Urbina EM, 2012, DIABETOLOGIA, V55, P625, DOI 10.1007/s00125-011-2412-1
   Urbina EM, 2010, J HYPERTENS, V28, P1692, DOI 10.1097/HJH.0b013e32833a6132
   *US DEP STAT, IMM VIS ISS ORPH COM
   Victora CG, 2010, PEDIATRICS, V125, pE473, DOI 10.1542/peds.2009-1519
   Walker SP, 2007, INT J OBESITY, V31, P347, DOI 10.1038/sj.ijo.0803383
   Weber T, 2004, CIRCULATION, V109, P184, DOI 10.1161/01.CIR.0000105767.94169.E3
   White IR, 2011, STAT MED, V30, P377, DOI 10.1002/sim.4067
   Yoshida T, 2006, INTERNAL MED, V45, P575, DOI 10.2169/internalmedicine.45.1534
NR 58
TC 14
Z9 16
U1 0
U2 6
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
EI 1097-6833
J9 J PEDIATR-US
JI J. Pediatr.
PD NOV
PY 2018
VL 202
BP 143
EP 149
DI 10.1016/j.jpeds.2018.06.047
PG 7
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA GX6YR
UT WOS:000447910300025
PM 30146113
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ferreira, TD
   Fernandes, JFR
   Araújo, LD
   Nogueira, LD
   Leal, PM
   Antunes, VP
   Rodrigues, MDG
   Valença, DCT
   Kaiser, SE
   Klein, MRST
AF Ferreira, Thais da Silva
   Rodrigues Fernandes, Julia Freitas
   Araujo, Luciene da Silva
   Nogueira, Livia de Paula
   Leal, Priscila Mansur
   Antunes, Vanessa Parada
   Guimaraes Rodrigues, Maria de Lourdes
   Torres Valenca, Debora Cristina
   Kaiser, Sergio Emanuel
   Simas Torres Klein, Marcia Regina
TI Serum Uric Acid Levels are Associated with Cardiometabolic Risk Factors
   in Healthy Young and Middle-Aged Adults
SO ARQUIVOS BRASILEIROS DE CARDIOLOGIA
LA English
DT Article
DE Uric Acid/metabolism; Oxidative Stress; Inflammation; Endothelium/
   dysfunction; Adults
ID ENDOTHELIAL FUNCTION; ARTERIAL STIFFNESS; INFLAMMATION; DYSFUNCTION;
   OBESITY; ATHEROSCLEROSIS; ADIPONECTIN; BIOMARKERS; PLASMA
AB Background: Observational studies have highlighted an association between serum uric acid (SUA) levels and cardiovascular risk factors. Despite the growing body of evidences, several studies were conducted in older individuals or in carriers of diseases susceptible to affect SUA levels and cardiometabolic risk markers.
   Objective: To evaluate the relationship of SUA with body adiposity, metabolic profile, oxidative stress, inflammatory biomarkers, blood pressure and endothelial function in healthy young and middle-aged adults.
   Methods: 149 Brazilian adults aged 20-55 years, both sexes, underwent evaluation of body adiposity, SUA, fasting glucose and insulin, lipid profile, malondialdehyde (MDA), high sensitivity C-reactive protein (hs-CRP), adiponectin, blood pressure and endothelial function. Endothelial function was assessed by the reactive hyperemia index (RHI) derived from peripheral arterial tonometry method. Participants were allocated in two groups according to SUA levels: control group (CG; n = 130; men <= 7 mg/dL, women <= 6 mg/dL) and hyperuricemia group (HG; n = 19; men > 7 mg/dL, women > 6 mg/dL). A P-value < 0.05 was considered statistically significant.
   Results: After adjustment for confounders, participants in HG compared with those in CG displayed higher body mass index (BMI): 34.15(33.36-37.19) vs.31.80 (26.26-34.42) kg/m(2),p = 0.008, higher MDA: 4.67(4.03-5.30) vs. 3.53(3.10-4.07) ng/mL, p < 0.0001 and lower RHI: 1.68 +/- 0.30 vs. 2.05 +/- 0.46, p = 0.03). In correlation analysis adjusted for confounders, SUA was positively associated (p < 0.05) with BMI, waist circumference, LDL-cholesterol, triglycerides and MDA, and negatively associated (p < 0.05) with HDL-cholesterol, adiponectin and RHI.
   Conclusions: This study suggests that in healthy young and middle-aged adults higher SUA levels are associated with higher body adiposity, unfavorable lipid and inflammatory phenotype, higher oxidative stress and impaired endothelial function.
C1 [Ferreira, Thais da Silva] Univ Fed Estado Rio de Janeiro UNIRIO, Rio De Janeiro, RJ, Brazil.
   [Ferreira, Thais da Silva; Rodrigues Fernandes, Julia Freitas; Araujo, Luciene da Silva; Nogueira, Livia de Paula; Leal, Priscila Mansur; Antunes, Vanessa Parada; Guimaraes Rodrigues, Maria de Lourdes; Torres Valenca, Debora Cristina; Kaiser, Sergio Emanuel; Simas Torres Klein, Marcia Regina] Univ Estado Rio de Janeiro UERJ, Rio De Janeiro, RJ, Brazil.
C3 Universidade Federal do Estado do Rio de Janeiro; Universidade do Estado
   do Rio de Janeiro
RP Ferreira, TD (corresponding author), Dept Nutr Aplicada, Ave Pasteur,296 Predio Escola Nutr, BR-22290240 Rio De Janeiro, RJ, Brazil.
EM thaissferreira@gmail.com
RI antunes, vanessa/C-8225-2018; Klein, Marcia/AAA-1695-2022; Rodrigues,
   Maria/KFR-3007-2024
OI Klein, Marcia/0000-0003-0298-3613
FU Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de
   Janeiro (FAPERJ)
FX This study was funded by Fundacao Carlos Chagas Filho de Amparo a
   Pesquisa do Estado do Rio de Janeiro (FAPERJ).
CR Al-Daghri NM, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-12085-0
   Altuntas A, 2016, INT J CLIN EXP MED, V9, P14105
   [Anonymous], 2017, Wkly Epidemiol Rec, V92, P241
   Billiet Laura, 2014, ISRN Rheumatol, V2014, P852954, DOI 10.1155/2014/852954
   Borghi C, 2015, J HYPERTENS, V33, P1729, DOI 10.1097/HJH.0000000000000701
   Brant LCC, 2013, J HYPERTENS, V31, P1984, DOI 10.1097/HJH.0b013e328362d913
   Caliceti C, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040395
   Canepa M, 2017, HYPERTENSION, V69, P228, DOI 10.1161/HYPERTENSIONAHA.116.08114
   Chen MY, 2017, SCI REP-UK, V7, DOI 10.1038/srep40009
   Chen Y, 2015, J ATHEROSCLER THROMB, V22, P823, DOI 10.5551/jat.26260
   Ciarla S, 2014, ARCH PHYSIOL BIOCHEM, V120, P119, DOI 10.3109/13813455.2014.924145
   de Oliveira EP, 2012, DIABETOL METAB SYNDR, V4, DOI 10.1186/1758-5996-4-12
   El Din UAAS, 2017, J ADV RES, V8, P537, DOI 10.1016/j.jare.2016.11.004
   Erdogan D, 2005, INT J CLIN PRACT, V59, P1276, DOI 10.1111/j.1742-1241.2005.00621.x
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Grygiel-Górniak B, 2018, MOL CELL BIOCHEM, V443, P111, DOI 10.1007/s11010-017-3215-6
   Huang XD., 2016, J CLIN EXP CARDIOL, V7, P1, DOI [10.4172/2155-9880.1000416, DOI 10.4172/2155-9880.1000416]
   Johnson RJ, 2013, DIABETES, V62, P3307, DOI 10.2337/db12-1814
   Kato M, 2005, AM J CARDIOL, V96, P1576, DOI 10.1016/j.amjcard.2005.07.068
   Kelley EE, 2010, FREE RADICAL BIO MED, V48, P493, DOI 10.1016/j.freeradbiomed.2009.11.012
   Lanaspa MA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048801
   Lanaspa MA, 2012, J BIOL CHEM, V287, P40732, DOI 10.1074/jbc.M112.399899
   Li Z Y, 2017, Zhonghua Yi Xue Za Zhi, V97, P2181, DOI 10.3760/cma.j.issn.0376-2491.2017.28.005
   Lippi G, 2008, CLIN CHIM ACTA, V392, P1, DOI 10.1016/j.cca.2008.02.024
   Malik R, 2016, AGING CLIN EXP RES, V28, P359, DOI 10.1007/s40520-015-0395-3
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Norvik JV, 2016, BMC CARDIOVASC DISOR, V16, DOI 10.1186/s12872-016-0265-8
   Park JS, 2012, MATURITAS, V73, P344, DOI 10.1016/j.maturitas.2012.09.009
   Prasad M, 2017, HYPERTENSION, V69, P236, DOI 10.1161/HYPERTENSIONAHA.116.08436
   Richette P, 2010, LANCET, V375, P318, DOI 10.1016/S0140-6736(09)60883-7
   Ruggiero C, 2006, EUR HEART J, V27, P1174, DOI 10.1093/eurheatj/ehi879
   Sichieri R, 1998, NUTR RES, V18, P1649, DOI 10.1016/S0271-5317(98)00151-1
   Solbu MD, 2016, KIDNEY BLOOD PRESS R, V41, P623, DOI 10.1159/000447931
   Srikanthan K, 2016, INT J MED SCI, V13, P25, DOI 10.7150/ijms.13800
   ter Horst KW, 2017, NUTRIENTS, V9, DOI 10.3390/nu9090981
   Tsushima Y, 2013, J BIOL CHEM, V288, P27138, DOI 10.1074/jbc.M113.485094
   Valle M, 2015, PEDIATR DIABETES, V16, P441, DOI 10.1111/pedi.12199
   Wu AH, 2016, INT J CARDIOL, V213, P4, DOI 10.1016/j.ijcard.2015.08.110
   Zheng RJ, 2017, CLIN LAB, V63, P1581, DOI 10.7754/Clin.Lab.2017.170311
   Zoccali C, 2006, J AM SOC NEPHROL, V17, P1466, DOI 10.1681/ASN.2005090949
NR 40
TC 19
Z9 20
U1 0
U2 4
PU ARQUIVOS BRASILEIROS CARDIOLOGIA
PI RIO DE JANEIRO
PA AVENIDA MARECHAL CAMARA 160-330 CENTRO, RIO DE JANEIRO, RJ 20 020-907,
   BRAZIL
SN 0066-782X
EI 1678-4170
J9 ARQ BRAS CARDIOL
JI Arq. Bras. Cardiol.
PD DEC
PY 2018
VL 111
IS 6
BP 833
EP 840
DI 10.5935/abc.20180197
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA HC6QZ
UT WOS:000451927700014
PM 30328946
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Chang, CH
AF Chang, Chia-Hao
TI Cohen's kappa for capturing discrimination
SO INTERNATIONAL HEALTH
LA English
DT Article
DE Area under the ROC curve; Cohen's kappa; Cut-off value; Power; Receiver
   operating characteristic curve
ID METABOLIC SYNDROME; CANCER; COEFFICIENT; PREVALENCE; DEPRESSION;
   PREDICTION; STROKE; TOOL
AB Identification of cut-off values for key biomarkers of clinical risk is a useful clinical tool. The kappa coefficient is a popular descriptive statistical measure for summarising the cross classification of two nominal variables with identical classes. On the basis of this definition, I propose that the kappa coefficient can also be used to capture discrimination, in the same way that the receiver operating characteristic (ROC) curve is used in preventive epidemiology studies.
   The statistics were determined using Cohen's kappa statistics for a gold standard and a continuous biomarker. The proposed design is compared with the ROC curve by applying it to articles on the metabolic syndrome and a colon cancer clinical trial.
   The two methods gave similar results. Moreover, Monte Carlo simulation results confirm that, from a power perspective, the proposed method is to be preferred. In general, the proposed method has higher power than the area under the ROC curve (AUC) for a study of positively correlative design.
   Overall, the power performance of the proposed method is better that that of the AUC.
C1 Chang Gung Univ Sci & Technol, Dept Nursing, Chiayi 61363, Taiwan.
C3 Chang Gung University of Science & Technology
RP Chang, CH (corresponding author), Chang Gung Univ Sci & Technol, Dept Nursing, Chiayi Campus, Chiayi 61363, Taiwan.
EM howellchang@gmail.com
FU Chang Gung Medical Research Grant [CMRPF680021, CMRPF690011]
FX This work was supported by Chang Gung Medical Research Grant [grant nos
   CMRPF680021, CMRPF690011].
CR [Anonymous], 1975, SIGNAL DETECTION THE
   Apfel CC, 2012, ANESTHESIOLOGY, V117, P475, DOI 10.1097/ALN.0b013e318267ef31
   Bollito E, 2012, ANAL QUANT CYTOL, V34, P96
   BRENNAN RL, 1981, EDUC PSYCHOL MEAS, V41, P687, DOI 10.1177/001316448104100307
   Brown JB, 2012, J TRAUMA ACUTE CARE, V73, P319, DOI 10.1097/TA.0b013e3182572bee
   Chang CH, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-708
   Chen JC, 2012, CLIN NEPHROL, V77, P392, DOI 10.5414/CN107174
   Chin CC, 2013, VISZERALMEDIZIN, V29, P125, DOI 10.1159/000350538
   COHEN J, 1960, EDUC PSYCHOL MEAS, V20, P37, DOI 10.1177/001316446002000104
   Dong YH, 2012, J NEUROL NEUROSUR PS, V83, P580, DOI 10.1136/jnnp-2011-302070
   FLEISS JL, 1975, BIOMETRICS, V31, P651, DOI 10.2307/2529549
   FLEISS JL, 1969, PSYCHOL BULL, V72, P323, DOI 10.1037/h0028106
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Green DM., 1967, Signal detection theory and psychophysics
   Gurevitch AJ, 2009, J GASTROINTEST SURG, V13, P100, DOI 10.1007/s11605-008-0643-3
   KRAEMER HC, 1979, PSYCHOMETRIKA, V44, P461, DOI 10.1007/BF02296208
   Nieuwenhuijse MJ, 2012, J BONE JOINT SURG AM, V94A, P874, DOI 10.2106/JBJS.K.00305
   Pepe MS, 2003, The statistical evaluation of medical tests for classification and prediction
   Spycher BD, 2012, J ALLERGY CLIN IMMUN, V130, P503, DOI 10.1016/j.jaci.2012.06.002
   Sun LC, 2009, BMC CANCER, V9, DOI 10.1186/1471-2407-9-288
   Tsiartas P, 2012, BJOG-INT J OBSTET GY, V119, P866, DOI 10.1111/j.1471-0528.2012.03328.x
   Turner A, 2012, STROKE, V43, P1000, DOI 10.1161/STROKEAHA.111.643296
   Villegas R, 2003, DIABETES CARE, V26, P3198, DOI 10.2337/diacare.26.11.3198-a
   Warrens MJ, 2008, PSYCHOMETRIKA, V73, P487, DOI 10.1007/s11336-008-9059-y
   Warrens MJ, 2010, PSYCHOMETRIKA, V75, P176, DOI 10.1007/s11336-009-9138-8
   Warrens MJ, 2008, J CLASSIF, V25, P177, DOI 10.1007/s00357-008-9023-7
   Williams JR, 2012, NEUROLOGY, V78, P998, DOI 10.1212/WNL.0b013e31824d587f
   ZWICK R, 1988, PSYCHOL BULL, V103, P374, DOI 10.1037/0033-2909.103.3.374
NR 28
TC 27
Z9 28
U1 2
U2 9
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1876-3413
EI 1876-3405
J9 INT HEALTH
JI Int. Health
PD JUN
PY 2014
VL 6
IS 2
BP 125
EP 129
DI 10.1093/inthealth/ihu010
PG 5
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA AJ6JM
UT WOS:000337799100009
PM 24691677
DA 2025-06-11
ER

PT J
AU Brunero, S
   Lamont, S
AF Brunero, Scott
   Lamont, Scott
TI Health behaviour beliefs and physical health risk factors for
   cardiovascular disease in an outpatient sample of consumers with a
   severe mental illness: A cross-sectional survey
SO INTERNATIONAL JOURNAL OF NURSING STUDIES
LA English
DT Article
DE Mental illness; Physical health; Health beliefs and attitudes
ID METABOLIC SYNDROME; SOCIOECONOMIC-STATUS; GENDER; CARE; CONSUMPTION;
   FAILURE; OBESITY; PEOPLE; IMPACT; RACE
AB Background Consumers with a mental illness have a significantly higher risk of physical health problems than the general population The role of health behaviour beliefs and their part in the health of consumers with a mental illness has been poorly explored in the literature
   Objectives To understand the relationship between physical health risk factors and health behaviour beliefs in consumers with schizophrenia
   Design A cross-sectional survey study design using the European Health and Behaviour Survey and assessing (n = 99) consumer's blood pressure, waist circumference, body mass index, smoking history, exercise levels, demographics, family history of diabetes and cardiovascular disease was used
   Settings The study was conducted in a 76-bed psychiatric facility located within a 550-bed metropolitan generalist hospital in Sydney, Australia
   Participants Patients attending an outpatient clozapine clinic at the mental health service were asked to participate in the survey by a nurse working in the clinic during the study period
   Results Of the 163 consumers asked to be involved in the study. 11 = 99 agreed to participate Mean waist circumference and body mass index for both males and females were significantly above normal population limits Overall, consumer's beliefs toward their health on the European Health and Behaviour Survey were positive, having statistically significantly more positive attitudes to the statements 'avoiding too much sugar', 'drinking no alcohol' and 'yearly blood pressure checks' than a previously published non-mental health consumer sample Whilst having positive attitude toward their healthcare, consumers' physical health risk parameters were higher than general population norms
   Conclusions Consumers with a mental illness have a significantly higher risk for serious physical health problems, yet possess high positive attitudes toward their physical health care. Models of care need to explore this contradiction within mental health services to improve patient outcomes. (C) 2009 Elsevier Ltd All rights reserved
C1 [Brunero, Scott; Lamont, Scott] NERU, EBB, Prince Wales Hosp, Sydney, NSW 2031, Australia.
C3 University of New South Wales Sydney; Prince of Wales Hospital (POWH)
RP Brunero, S (corresponding author), NERU, EBB, Prince Wales Hosp, Rm 7,High St, Sydney, NSW 2031, Australia.
RI brunero, scott/X-5634-2018; Lamont, Scott/KEH-2123-2024
OI Lamont, Scott/0000-0003-2497-1314; brunero, scott/0000-0003-4156-7014
FU New South Wales Nursing and Midwifery office Sydney Australia
FX The study was funded by the New South Wales Nursing and Midwifery office
   Sydney Australia.
CR Addington J, 1998, PSYCHIAT SERV, V49, P925, DOI 10.1176/ps.49.7.925
   *AIHW, 2008, AUSTR HLTH 2008 IS 1
   *AIHW, 2006, 73 AIHW AUS
   Ajzen I, 2002, J APPL SOC PSYCHOL, V32, P665, DOI 10.1111/j.1559-1816.2002.tb00236.x
   BARBOUR A, 1995, NEW ENGL J MED, V333, P1511
   Beck A. T., 1967, COGNITIVE THERAPY DE
   Bertakis KD, 2000, J FAM PRACTICE, V49, P147
   BRUNERO S, 2008, AUSTRALASIAN PSYCHIA, V16
   Brunero S, 2009, ARCH PSYCHIAT NURS, V23, P261, DOI 10.1016/j.apnu.2008.06.007
   Brunero S, 2009, INT J MENT HEALTH NU, V18, P144, DOI 10.1111/j.1447-0349.2009.00595.x
   Christensen AJ, 1999, HEALTH PSYCHOL, V18, P169, DOI 10.1037/0278-6133.18.2.169
   Clarke Kim E, 2002, J Vasc Nurs, V20, P96, DOI 10.1067/mvn.2002.127735
   COHEN A, 2001, PHYS HLTH ENDURING M, V3
   CONNOLLY M, 2005, ADV PSYCHIAT TREATME, V11, P124
   Eigenbrodt ML, 2001, AM J EPIDEMIOL, V153, P1102, DOI 10.1093/aje/153.11.1102
   ENGEL GL, 1977, SCIENCE, V196, P129, DOI 10.1126/science.847460
   Fiscella K, 2002, MED CARE, V40, P52, DOI 10.1097/00005650-200201000-00007
   Gore-Felton C, 2002, EVAL HEALTH PROF, V25, P152, DOI 10.1177/01678702025002002
   GOURNAY K, 1995, INT J NURS STUD, V32, P341, DOI 10.1016/0020-7489(95)00026-T
   Green CA, 1999, SOC SCI MED, V48, P1363, DOI 10.1016/S0277-9536(98)00440-7
   HAAGA DAF, 1991, PSYCHOL BULL, V110, P215, DOI 10.1037/0033-2909.110.2.215
   Hahm HC, 2005, AM J ORTHOPSYCHIAT, V75, P54, DOI 10.1037/0002-9432.75.1.54
   Hahm HC, 2008, J SOC WORK DISABIL R, V7, P94, DOI 10.1080/15367100802081110
   Haley CJ, 2003, SOC PSYCH PSYCH EPID, V38, P311, DOI 10.1007/s00127-003-0636-1
   Hemingway H, 1997, AM J PUBLIC HEALTH, V87, P1484, DOI 10.2105/AJPH.87.9.1484
   Hewitt J, 2005, J ADV NURS, V52, P561, DOI 10.1111/j.1365-2648.2005.03623.x
   HUGHES JR, 1995, PSYCHIATR SERV, V46, P435
   Johnson RJ, 2007, AM J CLIN NUTR, V86, P899
   KELLY C, 2000, ADV PSYCHIAT TREAT, V6, P327, DOI DOI 10.1192/APT.6.5.327
   Lamberti JS, 2006, AM J PSYCHIAT, V163, P1273, DOI 10.1176/appi.ajp.163.7.1273
   Lawrence D, 2001, DUTY CARE PREVENTABL
   Levenson H., 1981, Research with the locus of control construct, P15, DOI [10.1016/B978-0-12-443201-7.50006-3, DOI 10.1016/B978-0-12-443201-7.50006-3]
   Lobban F, 2004, PSYCHOL MED, V34, P1165, DOI 10.1017/S003329170400203X
   Marder SR, 2004, AM J PSYCHIAT, V161, P1334, DOI 10.1176/appi.ajp.161.8.1334
   MCKAY R, 2009, PHYS HLTH CARE MENTA
   Meyer JM, 2004, SCHIZOPHR RES, V70, P1, DOI 10.1016/j.schres.2004.01.014
   Mulaik J S, 1992, Issues Ment Health Nurs, V13, P219, DOI 10.3109/01612849209078775
   Nageotte C, 1997, SOC PSYCH PSYCH EPID, V32, P49, DOI 10.1007/BF00788920
   NASIALLAH H, 2004, J CLIN PSYCHOPHARM, V24, pS7
   Nejad L.M., 2005, EJournal of Applied Psychology, V1, P63, DOI [10.7790/ejap.v1i1.10, DOI 10.7790/EJAP.V1I1.10]
   Newcomer John W, 2004, J Clin Psychopharmacol, V24, pS1, DOI 10.1097/01.jcp.0000142281.85207.d5
   O'Brien A J, 2001, J Psychiatr Ment Health Nurs, V8, P129, DOI 10.1046/j.1365-2850.2001.00367.x
   Osler M, 2002, EUR J CLIN NUTR, V56, P57, DOI 10.1038/sj.ejcn.1601280
   Paeratakul S, 2002, INT J OBESITY, V26, P1205, DOI 10.1038/sj.ijo.0802026
   Palaniappan U, 2001, J NUTR, V131, P1952, DOI 10.1093/jn/131.7.1952
   Perkins DO, 2006, SCHIZOPHR RES, V83, P53, DOI 10.1016/j.schres.2005.10.016
   Poulin MJ, 2005, CAN J PSYCHIAT, V50, P555, DOI 10.1177/070674370505000909
   RETHERFORD M, 2006, DISS ABSTR INT B, V67, P2241
   Robson D, 2007, INT J NURS STUD, V44, P457, DOI 10.1016/j.ijnurstu.2006.07.013
   ROSENSTOCK IM, 1974, HEALTH EDUC QUART, V2, P328, DOI 10.1177/109019817400200403
   ROTTER JB, 1966, PSYCHOL MONOGR, V80, P1, DOI 10.1037/h0092976
   *ROYAL COLL PSYCH, 2009, FAIL DEAL MENT HLTH, P50
   Taylor D., 2009, The Maudsley prescribing guidelines, V10th
   Tomasson K, 1996, ADDICTION, V91, P1019, DOI 10.1111/j.1360-0443.1996.tb03598.x
   VICKERS RR, 1990, PREV MED, V19, P377, DOI 10.1016/0091-7435(90)90037-K
   WAIDLE J, 1991, SOC SCI MED, V33, P925
   Wu RR, 2008, JAMA-J AM MED ASSOC, V299, P185, DOI 10.1001/jama.2007.56-b
NR 57
TC 35
Z9 39
U1 0
U2 31
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0020-7489
EI 1873-491X
J9 INT J NURS STUD
JI Int. J. Nurs. Stud.
PD JUN
PY 2010
VL 47
IS 6
BP 753
EP 760
DI 10.1016/j.ijnurstu.2009.11.004
PG 8
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 596HP
UT WOS:000277676100011
PM 19959166
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Guimond, AJ
   Trudel-Fitzgerald, C
   Boehm, JK
   Qureshi, F
   Kubzansky, LD
AF Guimond, Anne-Josee
   Trudel-Fitzgerald, Claudia
   Boehm, Julia K.
   Qureshi, Farah
   Kubzansky, Laura D.
TI Is More, Better? Relationships of Multiple Psychological Well-Being
   Facets With Cardiometabolic Disease
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE psychological well-being; cardiometabolic disease; trajectories;
   longitudinal study; psychosocial factors
ID QUALITY-OF-LIFE; CARDIOVASCULAR HEALTH; PSYCHOSOCIAL FACTORS; SAS
   PROCEDURE; RISK; STROKE; ASSOCIATION; DEPRESSION; ANXIETY; MODEL
AB Objective: Cardiometabolic disease (CMD) is a leading cause of death and disability worldwide. Assessments of psychological well-being taken at one time point are linked to reduced cardiometabolic risk, but psychological well-being may change over time and how longitudinal trajectories of psychological well-being may be related to CMD risk remains unclear. Furthermore, psychological well-being is a multidimensional construct comprised of distinct facets, but no work has examined whether sustaining high levels of multiple facets may confer additive protection. This study tested if trajectories of four psychological well-being facets would be associated with lower risk of self-reported nonfatal CMD. Method: Participants were 4,006 adults aged >= 50 years in the English Longitudinal study of Ageing followed for 18 years at biyearly intervals. Psychological well-being facets were measured in Waves 1-5 using subscales of the Control, Autonomy, Satisfaction, and Pleasure scale. Latent class growth modeling defined trajectories of each facet. Incident CMD cases were self-reported at Waves 6-9. Cox regression models estimated likelihood of incident CMD associated with trajectories of each facet individually and additively (i.e., having persistently high levels on multiple facets over time). Results: After adjusting for relevant covariates, CMD risk was lower for adults with persistently high versus persistently low levels of control and autonomy. When considering potential additive effects, lower CMD risk was also related to experiencing persistently high levels of >= 2 versus 0 psychological well-being facets. Conclusions: Findings suggest having and sustaining multiple facets of psychological well-being is beneficial for cardiometabolic health, and that effects may be additive.
C1 [Guimond, Anne-Josee; Trudel-Fitzgerald, Claudia; Qureshi, Farah; Kubzansky, Laura D.] Harvard TH Chan Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA 02215 USA.
   [Guimond, Anne-Josee; Trudel-Fitzgerald, Claudia; Qureshi, Farah; Kubzansky, Laura D.] Harvard TH Chan Sch Publ Hlth, Lee Kum Sheung Ctr Hlth & Happiness, Boston, MA 02215 USA.
   [Boehm, Julia K.] Chapman Univ, Dept Psychol, Orange, CA USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health; Harvard
   University; Harvard T.H. Chan School of Public Health; Chapman
   University System; Chapman University
RP Guimond, AJ (corresponding author), Harvard TH Chan Sch Publ Hlth, Landmark Ctr, Dept Social & Behav Sci, 401 Pk Dr,4th Floor, Boston, MA 02215 USA.
EM aguimond@hsph.harvard.edu
RI Guimond, Anne-JosÃ©e/ABG-8892-2020; Boehm, Julia/LJL-2745-2024
OI Trudel-Fitzgerald, Claudia/0000-0001-9989-4259; Boehm,
   Julia/0000-0001-8360-9935; Qureshi, Farah/0000-0002-9092-8085; Guimond,
   Anne-Josee/0000-0002-1690-6312
FU Canadian Institutes of Health Research
FX Anne-Josee Guimond was supported by salary and training support from the
   Canadian Institutes of Health Research (postdoctoral fellowship) and the
   Lee Kum Sheung Center for Health and Happiness. The authors have no
   conflicts of interest to disclose. Statistical support was provided by
   data science specialists Steven Worthington and Jinjie Liu, at the
   Institute for Quantitative Social Science, Harvard University, and by
   Sebastien Haneuse, Professor of Biostatistics at the Harvard T. H. Chan
   School of Public Health.
CR Andruff H, 2009, TUTOR QUANT METHODS, V5, P11, DOI 10.20982/tqmp.05.1.p011
   [Anonymous], 2013, SAS/STAT 13.2 User's Guide
   Appleton AA, 2013, CIRCULATION, V127, P905, DOI 10.1161/CIRCULATIONAHA.112.115782
   Azuero A, 2016, CANCER-AM CANCER SOC, V122, P1298, DOI 10.1002/cncr.29924
   Banks J, 2019, English Longitudinal Study of Ageing: waves 0-9, 1998-2019, V37, DOI [10.5255/UKDA-SN-5050-16, DOI 10.5255/UKDA-SN-5050-16]
   Bell Melanie L, 2016, BMC Res Notes, V9, P479
   Benjamin EJ, 2018, CIRCULATION, V137, pE67, DOI [10.1161/CIR.0000000000000485, 10.1161/CIR.0000000000000558, 10.1161/CIR.0000000000000530]
   Boehm JK, 2020, PSYCHOSOM MED, V82, P774, DOI 10.1097/PSY.0000000000000855
   Boehm JK, 2018, HEALTH PSYCHOL, V37, P959, DOI 10.1037/hea0000643
   Boehm JK, 2017, AM J PREV MED, V53, P791, DOI 10.1016/j.amepre.2017.06.028
   Boehm JK, 2016, J PSYCHOSOM RES, V85, P1, DOI 10.1016/j.jpsychores.2016.03.018
   Boehm JK, 2015, PSYCHOL SCI, V26, P1063, DOI 10.1177/0956797615581491
   Boehm JK, 2012, PSYCHOL BULL, V138, P655, DOI 10.1037/a0027448
   Boyle SH, 2006, PSYCHOSOM MED, V68, P844, DOI 10.1097/01.psy.0000240779.55022.ff
   Carney RM, 2017, NAT REV CARDIOL, V14, DOI 10.1038/nrcardio.2016.181
   Columbia Public Health, 2021, LATENT GROWTH CURVE
   Diener E, 2017, APPL PSYCHOL-HLTH WE, V9, P133, DOI 10.1111/aphw.12090
   Duncan TE, 2004, BEHAV THER, V35, P333, DOI 10.1016/S0005-7894(04)80042-X
   Fancourt D, 2020, BRAIN BEHAV IMMUN, V83, P146, DOI 10.1016/j.bbi.2019.10.004
   Garfield LD, 2014, PSYCHOSOM MED, V76, P128, DOI 10.1097/PSY.0000000000000027
   Gilsanz P, 2017, STROKE, V48, P43, DOI 10.1161/STROKEAHA.116.013554
   GRAMBSCH PM, 1994, BIOMETRIKA, V81, P515
   Hyde M, 2003, AGING MENT HEALTH, V7, P186, DOI 10.1080/1360786031000101157
   Jones BL, 2001, SOCIOL METHOD RES, V29, P374, DOI 10.1177/0049124101029003005
   Jones BL, 2007, SOCIOL METHOD RES, V35, P542, DOI 10.1177/0049124106292364
   Kim ES, 2013, J PSYCHOSOM RES, V74, P427, DOI 10.1016/j.jpsychores.2013.01.013
   Kleinbaum D.G., 2010, SURVIVAL ANALYSES SE
   Kubzansky LD, 2018, J AM COLL CARDIOL, V72, P3012, DOI 10.1016/j.jacc.2018.10.023
   Lambiase MJ, 2015, HEALTH PSYCHOL, V34, P1043, DOI 10.1037/hea0000228
   Leger KA, 2021, ANN BEHAV MED, V55, P436, DOI 10.1093/abm/kaaa069
   Lim HJ, 2017, BMC GERIATR, V17, DOI 10.1186/s12877-017-0485-5
   Lucas RE, 2007, J RES PERS, V41, P1091, DOI 10.1016/j.jrp.2006.11.005
   Nagin, 2009, GROUP BASED MODELING
   NatCen, 2019, STUDY DOCUMENTATION
   Okura Y, 2004, J CLIN EPIDEMIOL, V57, P1096, DOI 10.1016/j.jclinepi.2004.04.005
   Panagi L, 2021, J EPIDEMIOL COMMUN H, V75, P297, DOI 10.1136/jech-2020-214302
   Poole L, 2020, PSYCHOL MED, V50, P1820, DOI 10.1017/S0033291719001879
   Pulkki-Råback L, 2015, CIRCULATION, V131, P245, DOI 10.1161/CIRCULATIONAHA.113.007104
   Radler BT, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-017-0646-8
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Roger VL, 2020, CIRCULATION, V141, pE104, DOI 10.1161/CIR.0000000000000756
   ROTH PL, 1994, PERS PSYCHOL, V47, P537, DOI 10.1111/j.1744-6570.1994.tb01736.x
   Ryff Carol D, 2015, Health Psychol Open, V2
   RYFF CD, 1995, J PERS SOC PSYCHOL, V69, P719
   Seaman SR, 2013, STAT METHODS MED RES, V22, P278, DOI 10.1177/0962280210395740
   Slopen N, 2018, Oxf. Handb. Integr. Health Sci., P75, DOI [10.1093/oxfordhb/9780190676384.013.5, DOI 10.1093/OXFORDHB/9780190676384.013.5]
   Steptoe A, 2019, ANNU REV PUBL HEALTH, V40, P339, DOI 10.1146/annurev-publhealth-040218-044150
   Steptoe A, 2013, INT J EPIDEMIOL, V42, P1640, DOI 10.1093/ije/dys168
   Trudel-Fitzgerald C, 2019, BMC PUBLIC HEALTH, V19, DOI 10.1186/s12889-019-8029-x
   U.K. Activity and Health Research, 1992, ALLIED DUNBAR NATL F
   Wiggins RD, 2008, SOC INDIC RES, V89, P61, DOI 10.1007/s11205-007-9220-5
   Willroth EC, 2020, PSYCHOSOM MED, V82, P650, DOI 10.1097/PSY.0000000000000832
   Zaninotto P, 2016, BMJ-BRIT MED J, V355, DOI 10.1136/bmj.i6267
NR 53
TC 5
Z9 5
U1 0
U2 34
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD JAN
PY 2022
VL 41
IS 1
BP 32
EP 42
DI 10.1037/hea0001154
PG 11
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA YR1PS
UT WOS:000749771200007
PM 35113584
DA 2025-06-11
ER

PT J
AU Li, MY
   Fang, QY
   Li, JZ
   Zheng, X
   Tao, J
   Yan, XH
   Lin, Q
   Lan, XL
   Chen, B
   Zheng, GH
   Chen, LD
AF Li, Moyi
   Fang, Qianying
   Li, Junzhe
   Zheng, Xin
   Tao, Jing
   Yan, Xinghui
   Lin, Qiu
   Lan, Xiulu
   Chen, Bai
   Zheng, Guohua
   Chen, Lidian
TI The Effect of Chinese Traditional Exercise-Baduanjin on Physical and
   Psychological Well-Being of College Students: A Randomized Controlled
   Trial
SO PLOS ONE
LA English
DT Article
ID METABOLIC SYNDROME; MENTAL-HEALTH; US; DISTRESS; QUALITY; FITNESS
AB Background
   The physical and mental health of college students tends to continuously decline around the world, therefore, it is important to improve their health during college period. Baduanjin, a traditional Chinese exercise which combines movements with breath and mind, may be one of the selectable effective exercises. However, the effect of Baduanjin exercise on college students has not been established. In this study, we systematically assessed the effectiveness and safety of Baduanjin exercise on physical and mental health of college students by a rigorous randomized, parallel-controlled design.
   Methods
   A total of 222 college students from Fujian University of Traditional Chinese Medicine were recruited and randomly allocated at an equal ratio into control or Baduanjin training. Participants in control group were informed to maintain their original activity habit, and those in Baduanjin exercise group received a 12-week Baduanjin exercise training with a frequency of 1 hour per day and 5 days per week on the basis of their original activity habit. The physical and psychological outcomes, including lumbar muscle strength, lower limb proprioception function, physical fitness, as well as self-reported symptom intensity, stress, self-esteem, mood, quality of life, quality of sleep, and adverse events, were evaluated at baseline, 13 weeks (at the end of 12-week intervention), and 25 weeks (after the 12-week follow-up period). Intention-to-treat analysis was performed for the above outcomes.
   Results
   Compared with controls, significant improvements in Baduanjin exercise group at the end of 12-week intervention period were found on lower limb proprioception function (the rate of average trace error on right lower limb (%): control 23.50 +/- 5.50, Baduanjin 21.92 +/- 6.54, P=0.004; the rate of average trace error on left lower limb (%): control 22.32 +/- 6.62, Baduanjin 20.63 +/- 4.62, P=0.046), cardiorespiratory endurance (step test index: control 47.66 +/- 5.94, Baduanjin 50.07 +/- 9.30, P=0.025), flexibility (control 14.35 +/- 7.26cm, Baduanjin 15.39 +/- 6.43cm, P=0.009) and explosive force of lower limb (standing long jump test (m): control 1.77 +/- 0.24, Baduanjin 1.79 +/- 0.22, P=0.005 for adjustment baseline) in physical outcomes, and attention (Schulte Grid test (second): control 210.4 +/- 51.15, Baduanjin 192.4 +/- 47.14, P=0.034) in mental outcome. Lumbar muscle strength in Baduanjin group had been moderately enhanced but no significant difference compared to controls. No significant changes in other physical and mental outcomes, including vital capacity, blood pressure, heart rate, hand grip force, self-symptom intensity, stress, self-efficacy, quality of life, and quality of sleep, were found between groups. No adverse event was reported during the study period.
   Conclusion
   Regular Baduanjin exercise had an advantage for college students on improvement of lower limb proprioception, enhance of cardiorespiratory endurance, flexibility, explosive force of lower limb and attention, compared with usual exercise.
C1 [Li, Moyi; Fang, Qianying; Li, Junzhe; Zheng, Xin; Tao, Jing; Lan, Xiulu; Chen, Bai; Zheng, Guohua] Fujian Univ Tradit Chinese Med, Coll Rehabil Med, Fuzhou, Fujian, Peoples R China.
   [Yan, Xinghui; Lin, Qiu] Fujian Univ Tradit Chinese Med, Dept Phys Educ, Fuzhou, Fujian, Peoples R China.
   [Chen, Lidian] Fujian Univ Tradit Chinese Med, Fuzhou, Fujian, Peoples R China.
C3 Fujian University of Traditional Chinese Medicine; Fujian University of
   Traditional Chinese Medicine; Fujian University of Traditional Chinese
   Medicine
RP Zheng, GH (corresponding author), Fujian Univ Tradit Chinese Med, Coll Rehabil Med, Fuzhou, Fujian, Peoples R China.
EM zhgh_1969@aliyun.com; lidianchen87@163.com
RI Zheng, Guo/E-8256-2013; Chen, Lidian/GSN-6461-2022; Tao,
   Jing/GVS-6340-2022
OI Chen, Lidian/0000-0002-8699-0839; Tao, Jing/0000-0002-4895-2065; Chen,
   Lidian/0000-0002-6454-7932; Tao, Jing/0000-0001-9751-5294
FU Rehabilitation Technology of Collaborative Innovation Center, FJTCM
   [X2012002-Collaboration]; Special Scientific Research Fund of Public
   Welfare Profession of China [201307004]; Ministry of Science and
   Technology; Ministry of Finance of the People's Republic of China
FX This study is funded by the Rehabilitation Technology of Collaborative
   Innovation Center, FJTCM (Grant No. X2012002-Collaboration), the Special
   Scientific Research Fund of Public Welfare Profession of China (Grant
   No. 201307004), Ministry of Science and Technology
   (http://www.most.gov.cn) and Ministry of Finance of the People's
   Republic of China (http://www.mof.gov.cn). The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
CR An BC, 2013, CHIN J INTEGR MED, V19, P143, DOI 10.1007/s11655-012-1211-y
   [Anonymous], 2006, Journal of America College Health, V55, P5
   [Anonymous], 2012, J Anhui Sport Sci
   [Anonymous], 2010, J FUJIAN U TRADIT CH
   [Anonymous], 2002, NAT COLL HLTH ASS WE
   Biddle SJH, 2011, BRIT J SPORT MED, V45, P886, DOI 10.1136/bjsports-2011-090185
   Boutron I, 2008, ANN INTERN MED, V148, P295, DOI 10.7326/0003-4819-148-4-200802190-00008
   Chen HH, 2006, AM J CHINESE MED, V34, P741, DOI 10.1142/S0192415X06004259
   Chen MC, 2012, INT J NURS STUD, V49, P265, DOI 10.1016/j.ijnurstu.2011.09.009
   Dyrbye LN, 2006, ACAD MED, V81, P354, DOI 10.1097/00001888-200604000-00009
   Fox KR, 1999, PUBLIC HEALTH NUTR, V2, P411, DOI 10.1017/S1368980099000567
   Geng YuanQing Geng YuanQing, 2008, China Journal of Traditional Chinese Medicine and Pharmacy, V23, P348
   Gore FM, 2011, LANCET, V377, P2093, DOI 10.1016/S0140-6736(11)60512-6
   Ha CH, 2012, IRAN J PUBLIC HEALTH, V41, P20
   Hamilton MT, 2007, DIABETES, V56, P2655, DOI 10.2337/db07-0882
   Health Qigong Management Center of General Administration of Sports of China, 2003, HLTH QIG BAD
   Hsu MC, 2008, AM J CHINESE MED, V36, P815, DOI 10.1142/S0192415X08006260
   Hunt J, 2010, J ADOLESCENT HEALTH, V46, P3, DOI 10.1016/j.jadohealth.2009.08.008
   Jiang X, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/942384
   Kang J, 2014, PREV MED, V64, P121, DOI 10.1016/j.ypmed.2014.03.023
   KOH TC, 1982, AM J CHINESE MED, V10, P14, DOI 10.1142/S0192415X8200004X
   Lepp A, 2013, INT J BEHAV NUTR PHY, V10, DOI 10.1186/1479-5868-10-79
   Li S, 2012, J JILIN I PHYS ED, V28, P13
   Liu H., 2008, JOURNAL-WUHAN Inst Phys Educ, V42, P54, DOI DOI 10.15930/J.CNKI.WTXB.2008.01.021
   Liu HF., 2007, J Beijing Sport Univ, P149
   Matthews CE, 2008, AM J EPIDEMIOL, V167, P875, DOI 10.1093/aje/kwm390
   Mei LJ, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/282131
   Miller KE, 2009, SOCIOL SPORT J, V26, P335, DOI 10.1123/ssj.26.2.335
   Mo GN., 2013, Wushu Sci, V10, P81
   Morrell JS, 2013, METAB SYNDR RELAT D, V11, P370, DOI 10.1089/met.2013.0011
   Nakamura T, 2008, ASIA PAC J CLIN NUTR, V17, P349
   Nelson Toben F, 2007, J Phys Act Health, V4, P495
   Owen N, 2010, EXERC SPORT SCI REV, V38, P105, DOI 10.1097/JES.0b013e3181e373a2
   Paluska SA, 2000, SPORTS MED, V29, P167, DOI 10.2165/00007256-200029030-00003
   Peng LY., 2012, SPORT RES, V2, P115, DOI 10.1371/journal.pone.0130544
   Qu XF, 2014, LIAONING SPORT SCI T, V36, P45
   Sagatun A, 2007, BMC PUBLIC HEALTH, V7, DOI 10.1186/1471-2458-7-155
   Stallman HM, 2008, AUST FAM PHYSICIAN, V37, P673
   Storrie K, 2010, INT J NURS PRACT, V16, P1, DOI 10.1111/j.1440-172X.2009.01813.x
   Ullrich-French S, 2011, PSYCHOL HEALTH, V26, P1063, DOI 10.1080/08870446.2010.530123
   Van Dyck D, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0120475
   Wang Y., 2011, J Beijing Sport Univ, V34, P102
   Wang Z.Y., 1984, Shanghai Achives of Psychiatry, V2, P68
   Werch CE, 2007, J ADOLESCENT HEALTH, V41, P577, DOI 10.1016/j.jadohealth.2007.06.003
   World Health Organization, 2008, GLOB BURD DIS 2004 U
   Yamazaki Fumio, 2013, Journal of UOEH, V35, P51
   Yang HG., 2013, J Xian Phys Educ Univ, V30, P315
   Yang HJ., 2011, Sport Res Educ, V26, P198
   Yang TZ, 2003, J CHIN EPIDEMIOL, V24, P760
   Yu G.B., 1995, Chinese qigong illustrated
   ZHANG JX, 1995, PSYCHOLOGIA, V38, P174
   Zhang X., 2011, Chin Med Mod Distance Educ China, V9, P105
   Zheng GH, 2013, TRIALS, V14, DOI 10.1186/1745-6215-14-422
   Zhou XQ., 2007, J Beijing Sport Univ, V30, P795
NR 54
TC 94
Z9 102
U1 11
U2 153
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 9
PY 2015
VL 10
IS 7
AR e0130544
DI 10.1371/journal.pone.0130544
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA CN1EW
UT WOS:000358161200013
PM 26158769
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU White, J
   Gray, RJ
   Swift, L
   Barton, GR
   Jones, M
AF White, Jacquie
   Gray, Richard J.
   Swift, Louise
   Barton, Garry R.
   Jones, Martin
TI The serious mental illness health improvement profile [HIP]: study
   protocol for a cluster randomised controlled trial
SO TRIALS
LA English
DT Article
ID CATIE SCHIZOPHRENIA TRIAL; WELL-BEING PROGRAM; PHYSICAL HEALTH;
   CARDIOVASCULAR RISK; METABOLIC SYNDROME; MANAGEMENT; INTERVENTION;
   STATEMENT; PEOPLE; IMPACT
AB Background: The serious mental illness Health Improvement Profile [HIP] is a brief pragmatic tool, which enables mental health nurses to work together with patients to screen physical health and take evidence-based action when variables are identified to be at risk. Piloting has demonstrated clinical utility and acceptability.
   Methods/Design: A single blind parallel group cluster randomised controlled trial with secondary economic analysis and process observation. Unit of randomisation: mental health nurses [MHNs] working in adult community mental health teams across two NHS Trusts. Subjects: Patients over 18 years with a diagnosis of schizophrenia, schizoaffective or bipolar disorder on the caseload of participating MHNs. Primary objective: To determine the effects of the HIP programme on patients' physical wellbeing assessed by the physical component score of the Medical Outcome Study (MOS) 36 Item Short Form Health Survey version 2 [SF-36v2]. Secondary objectives: To determine the effects of the HIP programme on: cost effectiveness, mental wellbeing, cardiovascular risk, physical health care attitudes and knowledge of MHNs and to determine the acceptability of the HIP Programme in the NHS. Consented nurses (and patients) will be randomised to receive the HIP Programme or treatment as usual. Outcomes will be measured at baseline and 12 months with a process observation after 12 months to include evaluation of patients' and professionals' experience and observation of any effect on care plans and primary-secondary care interface communication. Outcomes will be analysed on an intention-to-treat (ITT) basis.
   Discussion: The results of the trial and process observation will provide information about the effectiveness of the HIP Programme in supporting MHNs to address physical comorbidity in serious mental illness. Given the current unacceptable prevalence of physical comorbidity and mortality in the serious mental illness population, it is hoped the HIP trial will provide a timely contribution to evidence on organisation and delivery of care for patients, clinicians and policy makers.
C1 [White, Jacquie] Univ Hull, Fac Hlth & Social Care, Kingston Upon Hull HU6 7RX, N Humberside, England.
   [White, Jacquie; Barton, Garry R.] Univ E Anglia, Fac Hlth, Norwich NR4 7TJ, Norfolk, England.
   [Gray, Richard J.; Swift, Louise] Univ E Anglia, Fac Med & Hlth Sci, Norwich NR4 7TJ, Norfolk, England.
   [Jones, Martin] Univ Surrey, Guildford GU2 5XH, Surrey, England.
C3 University of Hull; University of East Anglia; University of East
   Anglia; University of Surrey
RP White, J (corresponding author), Univ Hull, Fac Hlth & Social Care, Kingston Upon Hull HU6 7RX, N Humberside, England.
EM jacqueline.white@hull.ac.uk
RI Jones, Martin/G-7810-2016; White, Jacquie/N-7287-2015; Gray,
   Richard/C-9945-2017
OI Jones, Martin/0000-0002-6463-3574; White, Jacquie/0000-0002-6196-2516;
   Gray, Richard/0000-0001-9694-4206
FU National Institute for Health Research [NIHR] [PB-PG-1208-18122];
   National Institutes of Health Research (NIHR) [PB-PG-1208-18122] Funding
   Source: National Institutes of Health Research (NIHR)
FX This paper presents independent research commissioned by the National
   Institute for Health Research [NIHR] under its Research for Patient
   benefit [RfPB] Programme (Grant Reference Number PB-PG-1208-18122). The
   views expressed are those of the authors and not necessarily those of
   the National Health Service, the NIHR or the Department of Health.
CR [Anonymous], ANN REL 2010 DOC
   [Anonymous], MENTAL HLTH PRACTICE
   [Anonymous], SCHIZ COR INT TREATM
   [Anonymous], GUID METH TECHN APPR
   [Anonymous], MAN BIP DIS AD CHILD
   [Anonymous], VAL ACT CHEIF NURS O
   [Anonymous], FAU TREATMENTCLOSING
   [Anonymous], MENTAL HLTH NURSE PH
   [Anonymous], 2006, CHOOS HLTH SUPP PHYS
   [Anonymous], CONS EX TREATM POL V
   [Anonymous], COR INT TREATM MAN S
   [Anonymous], 2009, NEW HOR SHAR VIS MEN
   [Anonymous], NO VOIC NO CHOIC JOI
   [Anonymous], 2007, USERS MANUAL SF36V2
   [Anonymous], COCHRANE DATABASE SY
   [Anonymous], 2006, PREVENTING CHRONIC D
   [Anonymous], DEV EV COMPL INT NEW
   Barnes TRE, 2008, ACTA PSYCHIAT SCAND, V118, P26, DOI 10.1111/j.1600-0447.2008.01203.x
   Barton GR, 2008, VALUE HEALTH, V11, P886, DOI 10.1111/j.1524-4733.2008.00358.x
   Barton GR, 2009, SCHIZOPHR RES, V112, P158, DOI 10.1016/j.schres.2009.03.041
   Braun V., 2006, QUAL RES PSYCHOL, V3, P77, DOI [DOI 10.1191/1478088706QP063OA, DOI 10.1080/14780887.2020.1769238]
   Brooks R, 1996, HEALTH POLICY, V37, P53, DOI 10.1016/0168-8510(96)00822-6
   Burns T, 1998, BRIT J GEN PRACT, V48, P1415
   Campbell MK, 2004, BMJ-BRIT MED J, V328, P702, DOI 10.1136/bmj.328.7441.702
   Chisholm D, 2000, BRIT J PSYCHIAT, V177, pS28, DOI 10.1192/bjp.177.39.s28
   Eldridge D, 2011, BMC PSYCHIATRY, V11, DOI 10.1186/1471-244X-11-46
   Friedlander AH, 2002, J AM DENT ASSOC, V133, P603, DOI 10.14219/jada.archive.2002.0236
   Gournay K, 1996, Nurs Times, V92, P36
   Gray R, 2004, BRIT J PSYCHIAT, V185, P157, DOI 10.1192/bjp.185.2.157
   Gray R, 2003, INT J NURS STUD, V40, P163, DOI 10.1016/S0020-7489(02)00045-7
   Guest G, 2006, FIELD METHOD, V18, P59, DOI 10.1177/1525822X05279903
   Haddad P, 2005, J PSYCHOPHARMACOL, V19, pA1
   Halbreich Uriel, 2003, J Psychiatr Pract, V9, P344, DOI 10.1097/00131746-200309000-00003
   Hippisley-Cox J, 2008, BMJ-BRIT MED J, V336, P1475, DOI 10.1136/bmj.39609.449676.25
   Jordan S, 2002, J ADV NURS, V37, P155, DOI 10.1046/j.1365-2648.2002.02064.x
   Lincoln Y.S., 1985, HDB QUALITATIVE RES, DOI [DOI 10.1016/0147-1767(85)90062-8, 10.1016/0147-1767(85)90062-8]
   Marder SR, 2004, AM J PSYCHIAT, V161, P1334, DOI 10.1176/appi.ajp.161.8.1334
   McEvoy JP, 2005, SCHIZOPHR RES, V80, P19, DOI 10.1016/j.schres.2005.07.014
   Moher D, 2010, BMJ-BRIT MED J, V340, DOI [10.1016/j.jclinepi.2010.02.005, 10.1136/bmj.c869, 10.1186/1741-7015-8-18, 10.1016/j.ijsu.2011.10.001, 10.1136/bmj.c332, 10.4103/0976-500X.72352, 10.1186/1745-6215-11-32, 10.1016/j.jclinepi.2010.03.004]
   Morrison P, 2000, AUST NZ J PSYCHIAT, V34, P814, DOI 10.1080/j.1440-1614.2000.00821.x
   Nash M., 2005, Mental Health Practice, V9, P20, DOI DOI 10.7748/MHP2005.12.9.4.20.C1896
   Nasrallah HA, 2006, SCHIZOPHR RES, V86, P15, DOI 10.1016/j.schres.2006.06.026
   Osborn DPJ, 2010, BMC HEALTH SERV RES, V10, DOI 10.1186/1472-6963-10-61
   Paton C, 2004, ACTA PSYCHIAT SCAND, V110, P299, DOI 10.1111/j.1600-0447.2004.00372.x
   Phelan M, 2001, BRIT MED J, V322, P443, DOI 10.1136/bmj.322.7284.443
   Robson D, 2007, INT J NURS STUD, V44, P457, DOI 10.1016/j.ijnurstu.2006.07.013
   Roshanaei-Moghaddam B, 2009, PSYCHIAT SERV, V60, P147, DOI 10.1176/appi.ps.60.2.147
   Russo J, 1998, MED CARE, V36, P752, DOI 10.1097/00005650-199805000-00015
   Schulz K.F., 2010, J PHARMACOL PHARMACO, V340, pc332, DOI DOI 10.4103/0976-500X.72352
   Shahzad S, 2002, PSYCHOSOMATICS, V43, P354, DOI 10.1176/appi.psy.43.5.354
   Shuel F, 2010, INT J NURS STUD, V47, P136, DOI 10.1016/j.ijnurstu.2009.06.003
   Smith S, 2007, INT J CLIN PRACT, V61, P1971, DOI 10.1111/j.1742-1241.2007.01605.x
   Smith S, 2007, EUR PSYCHIAT, V22, P413, DOI 10.1016/j.eurpsy.2007.07.002
   Ware J.E., 2004, USE PSYCHOL TESTING, V3, P693
   White J, 2009, J PSYCHIATR MENT HLT, V16, P493, DOI 10.1111/j.1365-2850.2009.01375.x
   WILLIAMS A, 1990, HEALTH POLICY, V16, P199
NR 56
TC 17
Z9 17
U1 0
U2 26
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD JUL 4
PY 2011
VL 12
AR 167
DI 10.1186/1745-6215-12-167
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA 800WM
UT WOS:000293398400001
PM 21726440
OA Green Published, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Edward, KL
   Rasmussen, B
   Munro, I
AF Edward, Karen-leigh
   Rasmussen, Bodil
   Munro, Ian
TI Nursing Care of Clients Treated with Atypical Antipsychotics Who Have a
   Risk of Developing Metabolic Instability and/or Type 2 Diabetes
SO ARCHIVES OF PSYCHIATRIC NURSING
LA English
DT Article
ID BODY-MASS INDEX; SCHIZOPHRENIA-PATIENTS; BLOOD-GLUCOSE; HALOPERIDOL;
   RISPERIDONE; MEDICATION; OLANZAPINE; MELLITUS; BEHAVIOR; WEIGHT
AB Objective: The aim of this article is to present a current discussion related to the nursing care of clients treated with atypical antipsychotic medicines and who have a risk of developing metabolic instability and/or Type 2 diabetes. The importance of such a discussion is to provide both the novice and the experienced nurse with additional knowledge of this current health issue with which to inform their nursing practice.
   Discussion: The potential for psychosis to be a chronic condition is very high, and often people require antipsychotic medicine for lengthy periods throughout their lives. Sometimes, treatment is for life. The second generation of antipsychotic medicines was greeted with much enthusiasm since it was better tolerated than the first generation. However, each medication has desired and adverse effects and, when taken for lengthy periods, these effects may produce physical illness. Studies show that the prevalence of Type 2 diabetes and the metabolic syndrome was significantly higher in clients with a chronic psychiatric disorder, particularly schizophrenia.
   Conclusions: Metabolic instability, especially weight gain, is associated with some psychotropic medicines. Nursing interventions need to include care assessment, planning, intervention, and evaluation for clients treated with antipsychotic medicines in terms of risk minimization strategies in routine nursing care. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Edward, Karen-leigh] Australian Catholic Univ, Ctr Nursing Res, Melbourne, Vic 3065, Australia.
   Deakin Univ, Sch Nursing, Melbourne, Vic, Australia.
   Monash Univ, Sch Nursing, Melbourne, Vic 3004, Australia.
C3 Australian Catholic University; Australian Catholic University -
   Melbourne Campus; Deakin University; Monash University
RP Edward, KL (corresponding author), Australian Catholic Univ, Ctr Nursing Res, POB 2900, Melbourne, Vic 3065, Australia.
RI Rasmussen, Bodil/M-7823-2015; Edward, Karen-leigh/H-3289-2014
OI Munro, Ian/0000-0002-3125-6952; Rasmussen, Bodil/0000-0002-6789-8260;
   Edward, Karen-leigh/0000-0001-8697-4006
CR *ADA, 2009, DIABETES CARE, V32, pS262
   *AIHW, 2008, 40 AIHW CVD
   *AIHW, 2007, 38 AIHW CVD NAT DIAB
   Barnes TRE, 2007, SCHIZOPHRENIA BULL, V33, P1397, DOI 10.1093/schbul/sbm038
   Bushe CJ, 2007, J CLIN PSYCHIAT, V68, P1682, DOI 10.4088/JCP.v68n1107
   Clarke P, 2006, J DIABETES COMPLICAT, V20, P349, DOI 10.1016/j.jdiacomp.2005.08.004
   Coodin S, 2001, CAN J PSYCHIAT, V46, P549, DOI 10.1177/070674370104600610
   *DAWN INT EXP ADV, 2004, DIABETES VOICE, V49
   DUNNING PL, 2003, CARE PEOPLE DIABETES
   Dunstan DW., 2001, Diabesity associated disorders in Australia-2000: The accelerating epidemic. The Australian Diabetes
   Grant BF, 2004, ARCH GEN PSYCHIAT, V61, P1107, DOI 10.1001/archpsyc.61.11.1107
   Haupt Dan W, 2007, J Clin Psychiatry, V68, pe24
   Henderson David C, 2006, Ann Clin Psychiatry, V18, P99, DOI 10.1080/10401230600614538
   Henderson DC, 2007, J CLIN PSYCHIAT, V68, P533, DOI 10.4088/JCP.v68n0407
   Jarboe K., 2007, J AM PSYCHIAT NURSES, V13, pS23
   Julien R.M., 2008, PRIMER DRUG ACTION C, V11th
   Kilbourne AM, 2007, BIPOLAR DISORD, V9, P443, DOI 10.1111/j.1399-5618.2007.00386.x
   Knight KM, 2006, DIABETIC MED, V23, P485, DOI 10.1111/j.1464-5491.2005.01802.x
   Montez JK, 2005, QUAL HEALTH RES, V15, P1086, DOI 10.1177/1049732305276677
   Murashita M, 2007, PSYCHONEUROENDOCRINO, V32, P777, DOI 10.1016/j.psyneuen.2007.05.007
   Murphy H., 2006, Journal of Mental Health, V15, P289, DOI [DOI 10.1080/09638230600700771, 10.1080/09638230600700771, DOI 10.1038/nrn844]
   *NASMHPD, 2008, PRINC ANT PRESCR POL
   Newcomer John W, 2007, J Clin Psychiatry, V68, pe17
   Osterberg L, 2005, NEW ENGL J MED, V353, P487, DOI 10.1056/NEJMra050100
   Perez-Iglesias R, 2007, J CLIN PSYCHIAT, V68, P1733, DOI 10.4088/JCP.v68n1113
   Polonsky WH, 2005, DIABETES CARE, V28, P626, DOI 10.2337/diacare.28.3.626
   Poulin MJ, 2007, AUST NZ J PSYCHIAT, V41, P980, DOI 10.1080/00048670701689428
   Rubin RR, 2001, J CLIN PSYCHOL, V57, P457, DOI 10.1002/jclp.1041
   Saddichha S, 2007, J CLIN PSYCHIAT, V68, P1793
   Scheen AJ, 2007, DIABETES METAB, V33, P169, DOI 10.1016/j.diabet.2007.01.003
   SNOEK FJ, 2004, DIABETES VOICE, V49, P28
   Thorne S, 2003, QUAL HEALTH RES, V13, P1337, DOI 10.1177/1049732303258039
   Trief P.M., 2006, FAMILIES SYSTEMS HLT, V24, P318, DOI [DOI 10.1037/1091-7527.24.3, 10.1037/1091-7527.24.3.318]
   Tschoner A, 2007, INT J CLIN PRACT, V61, P1356, DOI 10.1111/j.1742-1241.2007.01416.x
   WALKER C, 2003, CHRONIC ILLNESS NEW
   Wang PS, 2002, J CLIN PSYCHOPHARM, V22, P236, DOI 10.1097/00004714-200206000-00002
   Oladele CRW, 2006, BMC PUBLIC HEALTH, V6, DOI 10.1186/1471-2458-6-259
   Wooten J, 2007, SOUTH MED J, V100, P771, DOI 10.1097/SMJ.0b013e318063e8ef
   Zimmet Paul, 2003, Heart Lung Circ, V12 Suppl 2, pS95, DOI 10.1046/j.1443-9506.2003.t01-11-.x
NR 39
TC 26
Z9 29
U1 0
U2 11
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0883-9417
EI 1532-8228
J9 ARCH PSYCHIAT NURS
JI Arch. Psychiatr. Nurs.
PD FEB
PY 2010
VL 24
IS 1
BP 46
EP 53
DI 10.1016/j.apnu.2009.04.009
PG 8
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 584FG
UT WOS:000276735700007
PM 20117688
DA 2025-06-11
ER

PT J
AU Skórkowska-Telichowska, K
   Kropielnicka, K
   Bulinska, K
   Pilch, U
   Wozniewski, M
   Szuba, A
   Jasinski, R
AF Skorkowska-Telichowska, Katarzyna
   Kropielnicka, Katarzyna
   Bulinska, Katarzyna
   Pilch, Urszula
   Wozniewski, Marek
   Szuba, Andrzej
   Jasinski, Ryszard
TI Nordic walking in the second half of life
SO AGING CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Review
DE Physical rehabilitation; Elderly; Diseases of advanced age;
   Atherosclerosis; Metabolic syndrome; Parkinson's disease
ID RANDOMIZED-CONTROLLED-TRIAL; QUALITY-OF-LIFE; TYPE-2 DIABETES-MELLITUS;
   LOW-BACK-PAIN; PHYSIOLOGICAL-RESPONSES; PARKINSONS-DISEASE;
   ELDERLY-WOMEN; ENERGY-EXPENDITURE; HEART-FAILURE; EXERCISE
AB The objective of this article is to review the literature regarding the effectiveness and safety of Nordic walking (NW) in therapeutic rehabilitation in patients of an advanced age.
   Randomized studies comparing NW with different patterns of long-lasting physical rehabilitation in older adults (average age 65 years) were selected for the review. Studies were identified through a Medline database search covering the last 21 years.
   Seventy-four studies on this subject were identified, 37 of them fulfilled the required criteria and 27 of these were analyzed in this review.
   Nordic walking provides a safe and effective way to enhance physical activity in the elderly. It could also serve as a method of rehabilitation that improves fitness, the performance and the exercise capacity of aged persons with diseases associated with an advanced age: cardiovascular diseases due to atherosclerosis; metabolic syndrome without diabetes; early stage Parkinson's disease; chronic obstructive pulmonary disease and lowering depression in women with Sjogren's Syndrome.
C1 [Skorkowska-Telichowska, Katarzyna; Kropielnicka, Katarzyna; Bulinska, Katarzyna; Pilch, Urszula; Wozniewski, Marek; Szuba, Andrzej] Reg Specialist Hosp Wroclaw, WroVasc Integrated Med Cardiovasc Ctr, Ctr Res & Dev, H Kaminski 73a St, PL-51124 Wroclaw, Poland.
   [Kropielnicka, Katarzyna; Bulinska, Katarzyna; Pilch, Urszula; Wozniewski, Marek; Jasinski, Ryszard] Sch Phys Educ Wroclaw, Dept Rehabil, IJ Paderewski 35 St, PL-51612 Wroclaw, Poland.
   [Skorkowska-Telichowska, Katarzyna; Szuba, Andrzej] 4th Mil Hosp, Dept Internal Med, R Weigla 5 St, PL-50981 Wroclaw, Poland.
   [Skorkowska-Telichowska, Katarzyna; Szuba, Andrzej] Wroclaw Med Univ, Div Angiol, K Bartla 5 St, PL-51618 Wroclaw, Poland.
C3 Wroclaw Medical University
RP Skórkowska-Telichowska, K (corresponding author), Reg Specialist Hosp Wroclaw, WroVasc Integrated Med Cardiovasc Ctr, Ctr Res & Dev, H Kaminski 73a St, PL-51124 Wroclaw, Poland.; Skórkowska-Telichowska, K (corresponding author), 4th Mil Hosp, Dept Internal Med, R Weigla 5 St, PL-50981 Wroclaw, Poland.; Skórkowska-Telichowska, K (corresponding author), Wroclaw Med Univ, Div Angiol, K Bartla 5 St, PL-51618 Wroclaw, Poland.
EM cathcor@poczta.onet.pl
RI Szuba, Andrzej/AAY-1162-2020; Bulińska, Katarzyna/AEO-7051-2022;
   Jasinski, Ryszard/X-8643-2018
OI Szuba, Andrzej/0000-0002-7555-6201; Wozniewski,
   Marek/0000-0002-8241-7808; Bulinska, Katarzyna/0000-0002-4233-176X;
   Jasinski, Ryszard/0000-0002-0156-8074
FU European Regional Development Fund within the Innovative Economy
   Operational Program
FX This publication is part of Project "WroVasc-Integrated Cardiovascular
   Centre", co-financed by the European Regional Development Fund, within
   the Innovative Economy Operational Program, 2007-2013 realized in the
   Regional Specialist Hospital, Research and Development Center in
   Wroclaw.
CR Baatile J, 2000, J REHABIL RES DEV, V37, P529
   Banerjee M, 2010, AM J SPORT MED, V38, P1229, DOI 10.1177/0363546509357609
   Breyer MK, 2010, RESP RES, V11, DOI 10.1186/1465-9921-11-112
   ChodzkoZajko WJ, 1997, J AGING PHYS ACTIV, V5, P1
   Chomiuk T, 2013, ARCH MED SCI, V9, P201, DOI 10.5114/aoms.2013.34559
   Church TS, 2002, RES Q EXERCISE SPORT, V73, P296, DOI 10.1080/02701367.2002.10609023
   Collins EG, 2011, INT J SPORTS MED, V32, P407
   Ebersbach G, 2014, ARCH PHYS MED REHAB, V95, P996, DOI 10.1016/j.apmr.2013.10.020
   Ebersbach G, 2010, MOVEMENT DISORD, V25, P1902, DOI 10.1002/mds.23212
   Figard-Fabre H, 2011, INT J SPORTS MED, V32, P407, DOI 10.1055/s-0030-1268461
   Figueiredo S, 2013, DISABIL REHABIL, V35, P968, DOI 10.3109/09638288.2012.717580
   Fritz B, 2011, GAIT POSTURE, V34, P234, DOI 10.1016/j.gaitpost.2011.05.004
   Fritz T, 2011, DIABETIC MED, V28, P1362, DOI 10.1111/j.1464-5491.2011.03348.x
   Gram B, 2010, CLIN J SPORT MED, V20, P355, DOI 10.1227/NEU.0b013e3181e56e0a
   Hagner W, 2009, MENOPAUSE, V16, P1009, DOI 10.1097/gme.0b013e31819c0924
   Hagner-Derengowska M, 2015, MENOPAUSE, V22, P1215, DOI 10.1097/GME.0000000000000446
   Hansen EA, 2009, J STRENGTH COND RES, V23, P1187, DOI 10.1519/JSC.0b013e31819f1e2b
   Hartvigsen J, 2010, BMC MUSCULOSKEL DIS, V11, DOI 10.1186/1471-2474-11-30
   Kamien D, 2008, PHYS ED SPORT, V52, P69
   Karinkanta S, 2005, GERONTOLOGY, V51, P116, DOI 10.1159/000082196
   Kawamoto R, 2015, ENDOCRINE, V48, P871, DOI 10.1007/s12020-014-0360-5
   Keast ML, 2013, CAN J CARDIOL, V29, P1470, DOI 10.1016/j.cjca.2013.03.008
   Kocur P., 2006, Medical Rehabilitation, V10, P9
   Kukkonen-Harjula K, 2007, SCAND J MED SCI SPOR, V17, P316, DOI 10.1111/j.1600-0838.2006.00585.x
   Langbein WE, 2002, J VASC SURG, V35, P887, DOI 10.1067/mva.2002.123756
   Lejczak A, 2011, EUR HEART J, V32, P612
   Lukasik A, 2011, GERIATRIA, V5, P315
   Mikalacki M, 2011, COLLEGIUM ANTROPOL, V35, P889
   Morgulec-Adamowicz N., 2011, Hum Movement, V12, P124, DOI [10.2478/v1003801100097, DOI 10.2478/V10038-011-0009-7]
   Oakley C, 2008, EUR J VASC ENDOVASC, V36, P689, DOI 10.1016/j.ejvs.2008.06.036
   Park HS, 2014, J PHYS THER SCI, V26, P1809, DOI 10.1589/jpts.26.1809
   Parkatti T, 2012, J AGING PHYS ACTIV, V20, P93, DOI 10.1123/japa.20.1.93
   Perrey S, 2008, J SPORT SCI MED, V7, P32
   Porcari JP, 1997, RES Q EXERCISE SPORT, V68, P161, DOI 10.1080/02701367.1997.10607992
   Purzycka D, 2011, NADCISNIENIE TETNICZ, V15, P335
   RODGERS CD, 1995, MED SCI SPORT EXER, V27, P607
   Schiffer T, 2006, EUR J APPL PHYSIOL, V98, P56, DOI 10.1007/s00421-006-0242-5
   Schiffer T, 2009, MED SCI SPORT EXER, V41, P663, DOI 10.1249/MSS.0b013e31818b9321
   Strömbeck BE, 2007, RHEUMATOLOGY, V46, P868, DOI 10.1093/rheumatology/kem004
   van Eijkeren FJM, 2008, MOVEMENT DISORD, V23, P2239, DOI 10.1002/mds.22293
   Wilk M., 2005, REHABILITACJA MEDYCZ, V9, P33
NR 41
TC 19
Z9 22
U1 1
U2 44
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1594-0667
EI 1720-8319
J9 AGING CLIN EXP RES
JI Aging Clin. Exp. Res.
PD DEC
PY 2016
VL 28
IS 6
BP 1035
EP 1046
DI 10.1007/s40520-016-0531-8
PG 12
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA EB7RW
UT WOS:000387588900001
PM 26803510
DA 2025-06-11
ER

PT J
AU Vladu, IM
   Cojan, TST
   Demetrian, A
   Cristea, OM
   Ene, CG
   Clenciu, D
AF Vladu, Ionela Mihaela
   Cojan, Tiberiu Stefanita Tenea
   Demetrian, Alin
   Cristea, Oana Mariana
   Ene, Cristina Gabriela
   Clenciu, Diana
TI The Presence of Chronic Kidney Disease in Relation to Age and Duration
   of Diabetes Mellitus
SO REVISTA DE CHIMIE
LA English
DT Article
DE Type 1 diabetes mellitus; chronic kidney
ID METABOLIC SYNDROME; RISK; STRESS
AB Chronic kidney disease (CKD) affects about 10-13% of the general population with a small proportion in the terminal renal disease stage requiring renal replacement therapy or renal transplantation. CKD is the new cause of mortaliOT in the US. CKD's prevalence increases with age. Diabetes mellitus is responsible for 50% of cases of chronic kidney disease being the most common cause.
C1 [Vladu, Ionela Mihaela; Clenciu, Diana] Univ Med & Pharm Craiova, Dept Metab & Nutr Dis, Filantropia Clin Hosp Craiova, 1 Filantropiei Str, Craiova 200143, Romania.
   [Cojan, Tiberiu Stefanita Tenea] Univ Med & Pharm Craiova, Dept Surg, CFR Hosp Craiova, Stirbei Voda Str, Craiova 200374, Romania.
   [Demetrian, Alin] Univ Med & Pharm Craiova, Dept Thorac Surg, Cty Hosp Craiova, 2-4 Petru Rares Str, Craiova 200349, Romania.
   [Cristea, Oana Mariana] Univ Med & Pharm Craiova, Dept Microbiol, Cty Hosp Craiova, 2-4 Petru Rares Str, Craiova 200349, Romania.
   [Ene, Cristina Gabriela] Univ Med & Pharm Craiova, Pharmacol Dept, Cty Hosp Craiova, 2-4 Petru Rares Str, Craiova 200349, Romania.
C3 University of Medicine & Pharmacy of Craiova; University of Medicine &
   Pharmacy of Craiova; University of Medicine & Pharmacy of Craiova;
   University of Medicine & Pharmacy of Craiova; University of Medicine &
   Pharmacy of Craiova
RP Cojan, TST (corresponding author), Univ Med & Pharm Craiova, Dept Surg, CFR Hosp Craiova, Stirbei Voda Str, Craiova 200374, Romania.
EM doctortts@yahoo.com
RI Vladu, Mihaela/AAA-6254-2021; Clenciu, Diana/AAA-6152-2021
OI Cristea, Oana Mariana/0000-0003-0869-6738; Clenciu,
   Diana/0000-0002-5832-0715; Vladu, Mihaela/0000-0002-6133-4341
CR [Anonymous], ANN INTERN MED
   Baleanu VD, 2018, REV CHIM-BUCHAREST, V69, P1740
   Brenner B., 1997, Kidney Int, V52, P124
   Buicu GE, 2017, EUR PSYCHIAT, V41, pS583, DOI 10.1016/j.eurpsy.2017.01.880
   Calborean V, 2018, REV CHIM-BUCHAREST, V69, P4237
   Calborean V, 2018, REV CHIM-BUCHAREST, V69, P2461
   Calborean V, 2018, J CARDIOVASC EMERG, V4, P101, DOI 10.2478/jce-2018-0009
   Calborean V, 2018, REV CHIM-BUCHAREST, V69, P1527
   Calborean V, 2018, REV CHIM-BUCHAREST, V69, P1134
   Calborean V, 2017, REV CHIM-BUCHAREST, V68, P3010
   Chimorgiachis A, 2007, J NEURAL TRANSM, V114, pCXX
   Cojan TST, 2012, CHIRURGIA-BUCHAREST, V107, P616
   Corîci OM, 2018, ROM J MORPHOL EMBRYO, V59, P93
   Eknoyan G, 2002, AM J KIDNEY DIS, V39, pS14, DOI 10.1053/ajkd.2002.30939
   Ene CG, 2018, REV CHIM-BUCHAREST, V69, P1851
   Fortofoiu M, 2015, ROM J MORPHOL EMBRYO, V56, P1461
   Gheorman V, 2018, REV CHIM-BUCHAREST, V69, P881
   Gheorman V, 2016, ROM J MORPHOL EMBRYO, V57, P45
   KDIGO, 2013, Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease, V3, P5
   Levey AS, 2009, ANN INTERN MED, V150, P604, DOI 10.7326/0003-4819-150-9-200905050-00006
   Marinas AE, 2012, ROM J MORPHOL EMBRYO, V53, P957
   Mihailovici AR, 2018, REV CHIM-BUCHAREST, V69, P2209
   Novac MV, 2018, ROM J MORPHOL EMBRYO, V59, P715
   Puiu I, 2018, REV CHIM-BUCHAREST, V69, P2744
   Radu L, 2018, REV CHIM-BUCHAREST, V69, P3483
   Radu L, 2018, REV CHIM-BUCHAREST, V69, P2754
   Siminel MA, 2015, ROM J MORPHOL EMBRYO, V56, P301
   Socea B, 2018, REV CHIM-BUCHAREST, V69, P4012
   Stoenescu VE, 2017, ROM J MORPHOL EMBRYO, V58, P791
   Streba LAM, 2008, ROM J MORPHOL EMBRYO, V49, P13
   Trasca SP, 2018, REV CHIM-BUCHAREST, V69, P3600
   Vasile I, 2009, CHIRURGIA-BUCHAREST, V104, P281
   Vladu IM, 2018, REV CHIM-BUCHAREST, V69, P4229
   Vladu IM, 2018, REV CHIM-BUCHAREST, V69, P2479
   Vladu M, 2017, J NUTR METAB, V2017, DOI 10.1155/2017/6425359
   Vreju FA, 2016, MED ULTRASON, V18, P90, DOI 10.11152/mu.2013.2066.181.vej
   Whelton P K., 1989, Hypertension, V13, P19
NR 37
TC 1
Z9 1
U1 0
U2 14
PU REVISTA CHIMIE SRL
PI BUCURESTI
PA CALES PLEVNEI NR 139A, SECTOR 6, BUCURESTI, ROMANIA
SN 0034-7752
J9 REV CHIM-BUCHAREST
JI Rev. Chim.
PD APR
PY 2019
VL 70
IS 4
BP 1471
EP 1475
PG 5
WC Chemistry, Multidisciplinary; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering
GA IA2JK
UT WOS:000469387200076
DA 2025-06-11
ER

PT J
AU Estebanez, B
   Huang, CJ
   Rivera-Viloria, M
   Gonzalez-Gallego, J
   Cuevas, MJ
AF Estebanez, Brisamar
   Huang, Chun-Jung
   Rivera-Viloria, Marta
   Gonzalez-Gallego, Javier
   Cuevas, Maria J.
TI Exercise Outcomes in Childhood Obesity-Related Inflammation and
   Oxidative Status
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE adipokines; antioxidant systems; cytokines; children; exercise;
   inflammation; oxidative stress; physical activity
ID CIRCULATING OXIDIZED-LDL; ADIPOSE-TISSUE; ENDOTHELIAL DYSFUNCTION;
   OVERWEIGHT CHILDREN; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; VISCERAL FAT; WEIGHT-LOSS; BODY-FAT
AB Childhood obesity is identified as one of the major public health issues to increase the risk for cardiometabolic diseases and related complications in adulthood. The literature has supported inflammation and oxidative stress as the primary underlying mechanisms involved in the pathogenesis of obesity-related diseases. Epidemiological evidence consistently shows the benefits of physical activity in the improvement of obesity-mediated inflammation and oxidative stress status. In this narrative mini-review, the available scientific evidence on the potential effects of exercise in alleviating these susceptibilities in childhood obesity will be assessed.
C1 [Estebanez, Brisamar; Rivera-Viloria, Marta; Gonzalez-Gallego, Javier; Cuevas, Maria J.] Univ Leon, Inst Biomed IBIOMED, Leon, Spain.
   [Huang, Chun-Jung] Florida Atlantic Univ, Dept Exercise Sci & Hlth Promot, Exercise Biochem Lab, Boca Raton, FL USA.
   [Gonzalez-Gallego, Javier] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain.
C3 Universidad de Leon; State University System of Florida; Florida
   Atlantic University; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEREHD
RP Estebanez, B (corresponding author), Univ Leon, Inst Biomed IBIOMED, Leon, Spain.
EM b.estebanez@unileon.es
RI Gonzalez-Gallego, Javier/D-8219-2012; RIVERA VILORIA,
   MARTA/AEY-8301-2022; GONZÁLEZ, MARÍA/M-4927-2015; Estebanez,
   Brisamar/G-3863-2017
OI Estebanez, Brisamar/0000-0001-5034-9508; RIVERA VILORIA,
   MARTA/0000-0003-2109-1338; Gonzalez-Gallego, Javier/0000-0002-4386-9342
FU EXERNET Research Network on Physical Exercise and Health [09/UPB/19,
   45/UPB/20]; IN MOTU SALUS Research Network on Molecular and Cellular
   Basis of Physical Exercise for Health and Performance [14/UPB/19,
   09/UPB/20]
FX This project was supported by grants from the EXERNET Research Network
   on Physical Exercise and Health (09/UPB/19 and 45/UPB/20) and the IN
   MOTU SALUS Research Network on Molecular and Cellular Basis of Physical
   Exercise for Health and Performance (14/UPB/19 and 09/UPB/20).
CR Afshin A, 2017, NEW ENGL J MED, V377, P13, DOI 10.1056/NEJMoa1614362
   Ahmadian M, 2020, J SPORT MED PHYS FIT, V60, P779, DOI 10.23736/S0022-4707.20.10312-8
   Albuali Waleed H, 2014, World J Clin Pediatr, V3, P6, DOI 10.5409/wjcp.v3.i1.6
   AMIEL SA, 1986, NEW ENGL J MED, V315, P215, DOI 10.1056/NEJM198607243150402
   Araki S, 2010, EUR J PEDIATR, V169, P965, DOI 10.1007/s00431-010-1157-z
   Ben Ounis O, 2010, ANN NUTR METAB, V56, P260, DOI 10.1159/000275888
   Bianchi VE, 2015, J CARDIOPULM REHABIL, V35, P263, DOI 10.1097/HCR.0000000000000114
   Blüher S, 2014, OBESITY, V22, P1701, DOI 10.1002/oby.20739
   Calcaterra V, 2017, J PEDIATR ENDOCR MET, V30, P1257, DOI [10.1515/jpem-017-0239, 10.1515/jpem-2017-0239]
   Carbajo-Pescador S, 2019, DIS MODEL MECH, V12, DOI 10.1242/dmm.039206
   Carmona-Montesinos E, 2016, CHILD OBES, V12, P474, DOI 10.1089/chi.2016.0155
   Carolan E, 2014, J CLIN ENDOCR METAB, V99, pE474, DOI 10.1210/jc.2013-3529
   Chang CJ, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0125935
   Codoñer-Franch P, 2012, J PEDIATR-US, V161, P848, DOI 10.1016/j.jpeds.2012.04.046
   Codoñer-Franch P, 2011, ATHEROSCLEROSIS, V215, P475, DOI 10.1016/j.atherosclerosis.2010.12.035
   Codoñer-Franch P, 2010, PEDIATR DIABETES, V11, P251, DOI 10.1111/j.1399-5448.2009.00565.x
   Codoñer-Franch P, 2010, INT J PEDIATR OBES, V5, P56, DOI 10.3109/17477160903055945
   Dennis BA, 2013, CHILD OBES, V9, P15, DOI 10.1089/chi.2011.0092
   Dias I, 2015, MED SCI SPORT EXER, V47, P2636, DOI 10.1249/MSS.0000000000000705
   Diniz Tiego A, 2022, Methods Mol Biol, V2343, P119, DOI 10.1007/978-1-0716-1558-4_7
   Faienza MF, 2012, HORM RES PAEDIAT, V78, P158, DOI 10.1159/000342642
   Fang XY, 2020, CURR OPIN PEDIATR, V32, P805, DOI 10.1097/MOP.0000000000000953
   Farzanegi P, 2019, EUR J SPORT SCI, V19, P994, DOI 10.1080/17461391.2019.1571114
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Gonzalez-Gil AM, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061899
   Hallal PC, 2006, SPORTS MED, V36, P1019, DOI 10.2165/00007256-200636120-00003
   Hills AP, 2018, EUR J CLIN NUTR, V72, P1320, DOI 10.1038/s41430-018-0254-3
   Hills AP, 2011, BRIT J SPORT MED, V45, P866, DOI 10.1136/bjsports-2011-090199
   Jakicic JM, 2011, PSYCHIAT CLIN N AM, V34, P829, DOI 10.1016/j.psc.2011.08.009
   Jaksic M, 2019, J PEDIATR ENDOCR MET, V32, P951, DOI 10.1515/jpem-2019-0086
   Juarez-Fernandez M, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10122001
   Karczewski J, 2018, EUR CYTOKINE NETW, V29, P83, DOI 10.1684/ecn.2018.0415
   Kawanishi N, 2015, PHYSIOL REP, V3, DOI 10.14814/phy2.12534
   Kawanishi N, 2013, BIOCHEM BIOPH RES CO, V440, P774, DOI 10.1016/j.bbrc.2013.10.004
   Kawanishi N, 2013, MED SCI SPORT EXER, V45, P1684, DOI 10.1249/MSS.0b013e31828ff9c6
   Kelly AS, 2007, METABOLISM, V56, P1005, DOI 10.1016/j.metabol.2007.03.009
   Kelly AS, 2010, PEDIATR DIABETES, V11, P552, DOI 10.1111/j.1399-5448.2009.00640.x
   Kelly AS, 2004, J PEDIATR-US, V145, P731, DOI 10.1016/j.jpeds.2004.08.004
   Kelsey MM, 2020, J CLIN ENDOCR METAB, V105, DOI 10.1210/clinem/dgaa043
   Korda M, 2008, AM J PHYSIOL-HEART C, V295, pH1514, DOI 10.1152/ajpheart.00479.2008
   Kumar S, 2017, MAYO CLIN PROC, V92, P251, DOI 10.1016/j.mayocp.2016.09.017
   La Cava A, 2017, CYTOKINE, V98, P51, DOI 10.1016/j.cyto.2016.10.011
   Lechuga-Sancho AM, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0191547
   Lentferink YE, 2019, J PEDIATR ENDOCR MET, V32, P41, DOI 10.1515/jpem-2018-0237
   Lingappan Krithika, 2018, Current Opinion in Toxicology, V7, P81, DOI 10.1016/j.cotox.2017.11.002
   Liu M, 2016, PEDIATR EXERC SCI, V28, P55, DOI 10.1123/pes.2014-0221
   Magherini F, 2019, FREE RADICAL RES, V53, P1155, DOI 10.1080/10715762.2019.1697438
   Manna P, 2015, METAB SYNDR RELAT D, V13, P423, DOI 10.1089/met.2015.0095
   Marginean CO, 2020, CYTOKINE, V126, DOI 10.1016/j.cyto.2019.154925
   Martins JD, 2015, DNA CELL BIOL, V34, P274, DOI 10.1089/dna.2014.2752
   Mendelson M, 2015, PEDIATR OBES, V10, P311, DOI 10.1111/ijpo.255
   Merlin M, 2021, SPORT SCI HLTH, V17, P431, DOI 10.1007/s11332-020-00719-2
   Montero D, 2012, OBES REV, V13, P441, DOI 10.1111/j.1467-789X.2011.00956.x
   Murdolo G, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017264
   Nascimento H, 2016, PEDIATR EXERC SCI, V28, P407, DOI 10.1123/pes.2015-0261
   Nassis GP, 2005, METABOLISM, V54, P1472, DOI 10.1016/j.metabol.2005.05.013
   Nemet D, 2013, HORM RES PAEDIAT, V79, P325, DOI 10.1159/000348732
   Oliver SR, 2010, INT J PEDIATR OBES, V5, P436, DOI 10.3109/17477160903545163
   Ozgen IT, 2012, J PEDIATR ENDOCR MET, V25, P261, DOI 10.1515/jpem-2011-0397
   Paltoglou G, 2015, PEDIATR RES, V78, P158, DOI 10.1038/pr.2015.85
   Quiroga R, 2020, EXP MOL MED, V52, P1048
   Ramirez-De los Santos S, 2021, ODONTOLOGY, V109, P11, DOI 10.1007/s10266-020-00515-x
   Ringseis R, 2015, EXERC IMMUNOL REV, V21, P58
   Rius-Pérez S, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/1452696
   Roh HT, 2017, J SPORT HEALTH SCI, V6, P447, DOI 10.1016/j.jshs.2016.07.006
   Rowicka G, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/5621989
   Ruperez AI, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9070618
   Savini I, 2013, INT J MOL SCI, V14, P10497, DOI 10.3390/ijms140510497
   Schipper HS, 2012, DIABETOLOGIA, V55, P2800, DOI 10.1007/s00125-012-2641-y
   Sfar S, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-18
   Shih KC, 2010, METABOLISM, V59, P144, DOI 10.1016/j.metabol.2009.06.035
   Simmonds M, 2016, OBES REV, V17, P95, DOI 10.1111/obr.12334
   Singer K, 2014, OBESITY, V22, P1332, DOI 10.1002/oby.20710
   Sirico F, 2018, CHILD OBES, V14, P207, DOI 10.1089/chi.2017.0269
   Tenório TRS, 2018, PEDIATR EXERC SCI, V30, P98, DOI 10.1123/pes.2017-0067
   de Sousa BVO, 2021, MOL BIOL REP, V48, P4625, DOI 10.1007/s11033-021-06400-2
   Vasconcellos F, 2016, J SPORT SCI, V34, P564, DOI 10.1080/02640414.2015.1064150
   Vehapoglu A, 2016, REDOX REP, V21, P271, DOI 10.1080/13510002.2015.1133035
   Woo J, 2012, EUR J PEDIATR, V171, P235, DOI 10.1007/s00431-011-1518-2
   Yamagishi SI, 2003, MICROVASC RES, V65, P186, DOI 10.1016/S0026-2862(03)00005-0
   Yuksel HS, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17010347
NR 81
TC 3
Z9 3
U1 2
U2 19
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JUL 4
PY 2022
VL 9
AR 886291
DI 10.3389/fnut.2022.886291
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 3C0XQ
UT WOS:000828356000001
PM 35859754
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Diaz-Gerevini, GT
   Repossi, G
   Dain, A
   Tarres, MC
   Das, UN
   Eynard, AR
AF Diaz-Gerevini, G. T.
   Repossi, G.
   Dain, A.
   Tarres, M. C.
   Das, U. N.
   Eynard, A. R.
TI Cognitive and motor perturbations in elderly with longstanding diabetes
   mellitus
SO NUTRITION
LA English
DT Review
DE Diabetes mellitus; Insulin resistance; DE (Diabetic Encephalopathy);
   Oxidative stress; Dietary lipids
ID INSULIN-DEGRADING ENZYME; SEED PROANTHOCYANIDIN EXTRACTS;
   ANGIOTENSIN-ALDOSTERONE SYSTEM; POLYUNSATURATED FATTY-ACIDS; AMYLOID
   BETA-PROTEIN; OXIDATIVE STRESS; TAU PHOSPHORYLATION; INTRANASAL INSULIN;
   ALZHEIMERS-DISEASE; METABOLIC SYNDROME
AB Type 2 diabetes mellitus is a chronic disease characterized by insulin resistance; inflammation; oxidative stress; vascular damage; and dysfunction of glucose, protein, and lipid metabolisms. However, comparatively less attention has been paid to neurologic alterations seen in elderly individuals with type 2 diabetes. We review clinical, metabolic, and biochemical aspects of diabetic encephalopathy (DE) and propose that quality of dietary lipids is closely linked to DE. This implies that preventive nutritional interventions may be designed to improve DE. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Diaz-Gerevini, G. T.; Repossi, G.; Dain, A.; Eynard, A. R.] Univ Nacl Cordoba, CONICET, Fac Ciencias Med, INICSA, RA-5000 Cordoba, Argentina.
   [Repossi, G.] Univ Nacl La Rioja, Catedra Histol Embriol & Genet, La Rioja, Argentina.
   [Repossi, G.; Tarres, M. C.; Eynard, A. R.] Consejo Nacl Invest Cient & Tecn, RA-1033 Buenos Aires, DF, Argentina.
   [Tarres, M. C.] Univ Nacl Rosario, Fac Ciencias Med, RA-2000 Rosario, Argentina.
   [Das, U. N.] GVP Hosp, Dept Med, Visakhapatnam, Andhra Pradesh, India.
   [Das, U. N.] BioSci Res Ctr, Visakhapatnam, Andhra Pradesh, India.
   [Das, U. N.] UND Life Sci, Washington, DC USA.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   National University of Cordoba; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); National University of Rosario
RP Eynard, AR (corresponding author), Univ Nacl Cordoba, CONICET, Fac Ciencias Med, INICSA, RA-5000 Cordoba, Argentina.
EM Aeynard@gmail.com
RI Das, Undurti/A-7918-2009
OI Das, Undurti/0000-0002-0191-9508
FU PROMED of Ministerio de Educacion de la Nacion, Argentina; CONICET;
   SECYT-UNC; SECYT-UNLaR
FX GT Diaz-Gerevini and A. Dain are PhD students at Facultad de Ciencias
   Medicas, Universidad Nacional de Cordoba, Argentina. A. Dain is
   supported partially by a fellowship PROMED of Ministerio de Educacion de
   la Nacion, Argentina. This work was supported by funds provided by
   CONICET, SECYT-UNC, and SECYT-UNLaR.
CR Aballay LR, 2013, NUTR REV, V71, P168, DOI 10.1111/j.1753-4887.2012.00533.x
   Alquier T, 2006, DIABETES, V55, pS131, DOI 10.2337/db06-S021
   Amor S, 2010, IMMUNOLOGY, V129, P154, DOI 10.1111/j.1365-2567.2009.03225.x
   Andreatta MM, 2010, EUR J CANCER PREV, V19, P478, DOI 10.1097/CEJ.0b013e32833ebab6
   [Anonymous], DIABETES, DOI [10.1212/WNL.0b013e31828c2ee5, DOI 10.1212/WNL.0B013E31828C2EE5]
   [Anonymous], DIABETES CARE
   [Anonymous], AGEING RES REV
   [Anonymous], DIABETES CARE
   [Anonymous], PHARM THERAP
   [Anonymous], J NEURAL TRANSM
   [Anonymous], REV PORT CARDIOL
   Auer RN, 2004, METAB BRAIN DIS, V19, P169, DOI 10.1023/B:MEBR.0000043967.78763.5b
   Biessels GJ, 2002, EUR J PHARMACOL, V441, P1, DOI 10.1016/S0014-2999(02)01486-3
   Biessels GJ, 2009, CONTEMP DIABETES, P1, DOI 10.1007/978-1-60327-850-8
   Bingham EM, 2002, DIABETES, V51, P3384, DOI 10.2337/diabetes.51.12.3384
   Brown ES, 1999, NEUROPSYCHOPHARMACOL, V21, P474, DOI 10.1016/S0893-133X(99)00054-8
   Brownlee M, 2006, JAMA-J AM MED ASSOC, V295, P1707, DOI 10.1001/jama.295.14.1707
   Brownlee M, 2005, DIABETES, V54, P1615, DOI 10.2337/diabetes.54.6.1615
   Bunn RC, 2010, CARDIOVASC DIABETOL, V9, DOI 10.1186/1475-2840-9-73
   Calegari VC, 2011, J BIOL CHEM, V286, P12870, DOI 10.1074/jbc.M110.173021
   CHEN M, 1985, J CLIN ENDOCR METAB, V60, P13, DOI 10.1210/jcem-60-1-13
   Coste TC, 2003, DIABETES, V52, P2578, DOI 10.2337/diabetes.52.10.2578
   Daniele SM, 2000, J PHYSIOL BIOCHEM, V56, P45, DOI 10.1007/BF03179776
   Das U.N., 2010, Metabolic syndrome pathophysiology: the role of essential fatty acids
   Das UN, 2002, NUTRITION, V18, P667, DOI 10.1016/S0899-9007(02)00746-3
   Das UN, 2011, FRONT BIOSCI-LANDMRK, V16, P1, DOI 10.2741/3671
   Das UN, 2008, LIPIDS HEALTH DIS, V7, DOI 10.1186/1476-511X-7-9
   De Meyts P, 2002, NAT REV DRUG DISCOV, V1, P769, DOI 10.1038/nrd917
   Dickson DW, 1996, NEUROBIOL AGING, V17, P733
   Edbauer D, 2002, J BIOL CHEM, V277, P13389, DOI 10.1074/jbc.M111571200
   Espeland MA, 2011, J WOMENS HEALTH, V20, P1435, DOI 10.1089/jwh.2011.2812
   Exalto LG, 2012, EXP GERONTOL, V47, P858, DOI 10.1016/j.exger.2012.07.014
   Eynard AR, 2013, NUTRITION, V29, P930, DOI 10.1016/j.nut.2012.12.014
   Eynard AR, 1998, NUTRITION, V14, P211, DOI 10.1016/S0899-9007(97)00426-7
   Farris W, 2003, P NATL ACAD SCI USA, V100, P4162, DOI 10.1073/pnas.0230450100
   HAVRANKOVA J, 1981, DIABETOLOGIA, V20, P268, DOI 10.1007/BF00254492
   Heffelfinger AK, 2001, DEV PSYCHOPATHOL, V13, P491, DOI 10.1017/S0954579401003054
   Hernández-Fonseca JP, 2009, EXP DIABETES RES, DOI 10.1155/2009/329632
   Hershey T, 2010, DIABETES, V59, P236, DOI 10.2337/db09-1117
   Holt T., 2010, ABC da Diabetes
   Hong M, 1997, J BIOL CHEM, V272, P19547, DOI 10.1074/jbc.272.31.19547
   HUBBARD SR, 1994, NATURE, V372, P746, DOI 10.1038/372746a0
   Hudson BI, 2002, CURR SCI INDIA, V83, P1515
   Kamboj SS, 2011, MITOCHONDRION, V11, P214, DOI 10.1016/j.mito.2010.09.014
   Keanei DC, 2011, CLIN SCI, V120, P195, DOI 10.1042/CS20100282
   Kim B, 2013, J ALZHEIMERS DIS, V34, P727, DOI 10.3233/JAD-121669
   Kim B, 2009, ENDOCRINOLOGY, V150, P5294, DOI 10.1210/en.2009-0695
   Klein JP, 2003, LANCET NEUROL, V2, P548, DOI 10.1016/S1474-4422(03)00503-9
   Kodl CT, 2008, ENDOCR REV, V29, P494, DOI 10.1210/er.2007-0034
   Korf ESC, 2004, NEUROLOGY, V63, P94, DOI 10.1212/01.WNL.0000133114.92694.93
   Korf ESC, 2006, DIABETES CARE, V29, P2268, DOI 10.2337/dc06-0243
   Lakshmanan AP, 2011, FREE RADICAL RES, V45, P788, DOI 10.3109/10715762.2011.579121
   Lankinen M, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005258
   Lee BW, 2010, J KOREAN MED SCI, V25, P961, DOI 10.3346/jkms.2010.25.6.961
   Lee HK, 2009, MOL BIOL CELL, V20, P1533, DOI 10.1091/mbc.E08-07-0777
   Ling Y, 2003, INT J BIOCHEM CELL B, V35, P1505, DOI 10.1016/S1357-2725(03)00133-X
   Liu YF, 2003, NATURE, V423, P49, DOI 10.1038/nature01543
   Liu Y, 2011, J PATHOL, V225, P54, DOI 10.1002/path.2912
   Lu DY, 2010, NEUROPSYCHOPHARMACOL, V35, P2238, DOI 10.1038/npp.2010.98
   Lu M, 2010, J NUTR SCI VITAMINOL, V56, P87, DOI 10.3177/jnsv.56.87
   Maher PA, 2009, EXPERT REV NEUROTHER, V9, P617, DOI [10.1586/ern.09.18, 10.1586/ERN.09.18]
   Manschot SM, 2007, DIABETOLOGIA, V50, P2388, DOI 10.1007/s00125-007-0792-z
   Matias I, 2006, J CLIN ENDOCR METAB, V91, P3171, DOI 10.1210/jc.2005-2679
   McEwen BS, 2004, EUR J PHARMACOL, V490, P13, DOI 10.1016/j.ejphar.2004.02.041
   Miners JS, 2008, BRAIN PATHOL, V18, P240, DOI 10.1111/j.1750-3639.2008.00132.x
   Movsesyan VA, 2002, BIOCHEM BIOPH RES CO, V299, P201, DOI 10.1016/S0006-291X(02)02593-7
   Müllner E, 2013, MOL NUTR FOOD RES, V57, P328, DOI 10.1002/mnfr.201200343
   MUNOZ SE, 1995, PROSTAG LEUKOTR ESS, V53, P135, DOI 10.1016/0952-3278(95)90140-X
   Navarro A, 2004, NUTRITION, V20, P873, DOI 10.1016/j.nut.2004.06.008
   Navarro A, 2003, NUTRITION, V19, P7, DOI 10.1016/S0899-9007(02)00832-8
   Newcomer JW, 1999, ARCH GEN PSYCHIAT, V56, P527, DOI 10.1001/archpsyc.56.6.527
   Nguyen Dung V, 2012, Front Endocrinol (Lausanne), V3, P170, DOI 10.3389/fendo.2012.00170
   Niclis C, 2012, NUTR CANCER, V64, P23, DOI 10.1080/01635581.2012.630163
   Nielson KA, 1996, J AM GERIATR SOC, V44, P897, DOI 10.1111/j.1532-5415.1996.tb01857.x
   Okin D, 2012, CURR BIOL, V22, pR733, DOI 10.1016/j.cub.2012.07.029
   Oster T, 2010, BBA-MOL CELL BIOL L, V1801, P791, DOI 10.1016/j.bbalip.2010.02.011
   Ott A, 1996, DIABETOLOGIA, V39, P1392, DOI 10.1007/s001250050588
   Park JY, 2011, ARCH TOXICOL, V85, P1057, DOI 10.1007/s00204-011-0645-x
   Parker G, 2006, AM J PSYCHIAT, V163, P969, DOI 10.1176/appi.ajp.163.6.969
   Perkins JM, 2008, CURR OPIN ENDOCRINOL, V15, P147, DOI 10.1097/MED.0b013e3282f7026f
   Perry VH, 2010, NAT REV NEUROL, V6, P193, DOI 10.1038/nrneurol.2010.17
   Prpic-Krizevac I, 2012, WIEN KLIN WOCHENSCHR, V124, P403, DOI 10.1007/s00508-012-0191-4
   Qiu WQ, 1998, J BIOL CHEM, V273, P32730, DOI 10.1074/jbc.273.49.32730
   Qu ZS, 2011, BRAIN RES, V1383, P300, DOI 10.1016/j.brainres.2011.01.084
   Reger MA, 2006, NEUROBIOL AGING, V27, P451, DOI 10.1016/j.neurobiolaging.2005.03.016
   Reger MA, 2008, J ALZHEIMERS DIS, V13, P323, DOI 10.3233/jad-2008-13309
   Roriz JS, 2009, BBA-MOL BASIS DIS, V1792, P432, DOI 10.1016/j.bbadis.2008.12.003
   SCHELTENS P, 1993, J NEUROL SCI, V114, P7, DOI 10.1016/0022-510X(93)90041-V
   Schmidt AM, 2001, J CLIN INVEST, V108, P949, DOI 10.1172/JCI14002
   Schoolwerth AC, 2005, ADV CHRONIC KIDNEY D, V12, P418, DOI 10.1053/j.ackd.2005.07.012
   Schoolwerth Anton C, 2006, Prev Chronic Dis, V3, pA57
   Schwartz MW, 2005, SCIENCE, V307, P375, DOI 10.1126/science.1104344
   SHAMOON H, 1993, NEW ENGL J MED, V329, P977, DOI 10.1056/NEJM199307293290502
   Shimoji K, 2013, DIABETES CARE, V36, P696, DOI 10.2337/dc12-0666
   Sima Anders A F, 2009, Rev Diabet Stud, V6, P37, DOI 10.1900/RDS.2009.6.37
   Sinclair AJ, 2000, DIABETES RES CLIN PR, V50, P203, DOI 10.1016/S0168-8227(00)00195-9
   Skeberdis VA, 2001, P NATL ACAD SCI USA, V98, P3561, DOI 10.1073/pnas.051634698
   Sperandio S, 2004, CELL DEATH DIFFER, V11, P1066, DOI 10.1038/sj.cdd.4401465
   Sperandio S, 2000, P NATL ACAD SCI USA, V97, P14376, DOI 10.1073/pnas.97.26.14376
   Suryanarayana P, 2007, MED SCI MONITOR, V13, pBR286
   Takeda S, 2010, P NATL ACAD SCI USA, V107, P7036, DOI 10.1073/pnas.1000645107
   Takeda S, 2009, BIOCHEM BIOPH RES CO, V385, P193, DOI 10.1016/j.bbrc.2009.05.037
   TARRES MC, 1992, AM J PATHOL, V141, P761
   TROVATI M, 1989, METABOLISM, V38, P501, DOI 10.1016/0026-0495(89)90207-2
   Vargas R, 2012, BRAIN RES, V1453, P64, DOI 10.1016/j.brainres.2012.03.021
   Varma V, 2009, AM J PHYSIOL-ENDOC M, V296, pE1300, DOI 10.1152/ajpendo.90885.2008
   Vermeer SE, 2002, STROKE, V33, P21, DOI 10.1161/hs0102.101629
   Wickelgren I, 1998, SCIENCE, V280, P517, DOI 10.1126/science.280.5363.517
   Woods SC, 2006, DIABETES, V55, pS114, DOI 10.2337/db06-S015
   Wysocki T, 2003, DIABETES CARE, V26, P1100, DOI 10.2337/diacare.26.4.1100
   Xu L, 2008, EXP CLIN ENDOCR DIAB, V116, P215, DOI 10.1055/s-2007-993188
   Yaffe K, 2006, J NUTR HEALTH AGING, V10, P292
   Yang RH, 2012, NEUROSCIENCE, V212, P93, DOI 10.1016/j.neuroscience.2012.04.005
   Zhao CH, 2012, BRAIN RES, V1457, P33, DOI 10.1016/j.brainres.2012.03.067
   Zhao LX, 2004, J NEUROSCI, V24, P11120, DOI 10.1523/JNEUROSCI.2860-04.2004
   Zhao WQ, 1999, J BIOL CHEM, V274, P34893, DOI 10.1074/jbc.274.49.34893
   Ziegler D, 2005, CURR MOL MED, V5, P309, DOI 10.2174/1566524053766095
NR 117
TC 21
Z9 21
U1 1
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD JUN
PY 2014
VL 30
IS 6
BP 628
EP 635
DI 10.1016/j.nut.2013.11.007
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AH8WT
UT WOS:000336419600003
PM 24800665
OA Green Published
DA 2025-06-11
ER

PT J
AU Avogaro, A
   de Kreutzenberg, SV
   Fadini, G
AF Avogaro, Angelo
   de Kreutzenberg, Saula Vigili
   Fadini, GianPaolo
TI Endothelial dysfunction: Causes and consequences in patients with
   diabetes mellitus
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE Diabetes; Endothelium; Oxidative stress; Endothelium progenitor cells
ID POSTPRANDIAL MYOCARDIAL-PERFUSION; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   NITRIC-OXIDE; PROGENITOR CELLS; VASCULAR COMPLICATIONS;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; BRACHIAL-ARTERY;
   RISK-FACTORS
AB Vascular endothelium plays a major role in maintaining cardiovascular homeostasis. Nitric oxide is the most powerful vasodilating compound. Diabetes disrupts endothelial integrity through an increased oxidative stress. Recent evidence indicates that there is a strong interaction between diabetes, the secretory proteins of adipocytes, called adipokines, and endothelium. Endothelial dysfunction may precede the development of overt DM, and a prolonged and repeated exposure to postprandial hyperglycemia may play an important role in the development of atherosclerosis, even in those who have normal fasting plasma glucose levels. (C) 2008 Published by Elsevier Ireland Ltd.
C1 [Avogaro, Angelo; de Kreutzenberg, Saula Vigili; Fadini, GianPaolo] Univ Padua, Sch Med, Dept Clin & Expt Med, Padua, Italy.
C3 University of Padua
RP Avogaro, A (corresponding author), Univ Padua Polyclin, Dipartimento Med Clin & Sperimentale Malattie Met, Via Giustiniani 2, I-35100 Padua, Italy.
EM angelo.avogaro@unipd.it
RI Fadini, Gian/M-4575-2019; Avogaro, Angelo/S-3808-2016
OI FADINI, GIAN PAOLO/0000-0002-6510-2097; AVOGARO,
   ANGELO/0000-0002-1177-0516
CR Abdella NA, 2005, DIABETIC MED, V22, P278, DOI 10.1111/j.1464-5491.2004.01405.x
   Alam TA, 2005, EUR J VASC ENDOVASC, V29, P269, DOI 10.1016/j.ejvs.2004.12.019
   Aldhahi Waleed, 2003, Curr Diab Rep, V3, P293, DOI 10.1007/s11892-003-0020-2
   Asahara T, 1997, SCIENCE, V275, P964, DOI 10.1126/science.275.5302.964
   Avogaro A, 1997, DIABETES, V46, P1040, DOI 10.2337/diabetes.46.6.1040
   Avogaro A, 2003, J CLIN ENDOCR METAB, V88, P1753, DOI 10.1210/jc.2002-021025
   Avogaro A, 2003, DIABETES, V52, P795, DOI 10.2337/diabetes.52.3.795
   Boos CJ, 2006, J AM COLL CARDIOL, V48, P1538, DOI 10.1016/j.jacc.2006.02.078
   Bruunsgaard H, 2002, EUR CYTOKINE NETW, V13, P389
   Ceolotto G, 2007, ARTERIOSCL THROM VAS, V27, P2627, DOI 10.1161/ATVBAHA.107.155762
   Cohn JN, 2001, AM J HYPERTENS, V14, p218S, DOI 10.1016/S0895-7061(01)02092-1
   Corretti MC, 2002, J AM COLL CARDIOL, V39, P257, DOI 10.1016/S0735-1097(01)01746-6
   Delbosc S, 2005, ATHEROSCLEROSIS, V179, P43, DOI 10.1016/j.atherosclerosis.2004.10.018
   Devangelio E, 2007, FREE RADICAL BIO MED, V43, P511, DOI 10.1016/j.freeradbiomed.2007.03.015
   Fadini GP, 2006, ARTERIOSCL THROM VAS, V26, P2140, DOI 10.1161/01.ATV.0000237750.44469.88
   Fadini GP, 2005, J AM COLL CARDIOL, V45, P1449, DOI 10.1016/j.jacc.2004.11.067
   Feener E P, 2001, Heart Fail Monit, V1, P74
   Gallo A, 2005, DIABETES, V54, P1123, DOI 10.2337/diabetes.54.4.1123
   Irace C, 2001, ATHEROSCLEROSIS, V158, P53, DOI 10.1016/S0021-9150(01)00406-3
   KHAIDAR A, 1994, CIRCULATION, V90, P479, DOI 10.1161/01.CIR.90.1.479
   Koenig W, 2006, J AM COLL CARDIOL, V48, P1369, DOI 10.1016/j.jacc.2006.06.053
   Koh KK, 2005, J AM COLL CARDIOL, V46, P1978, DOI 10.1016/j.jacc.2005.06.082
   Lambiase PD, 2004, CIRCULATION, V109, P2986, DOI 10.1161/01.CIR.0000130639.97284.EC
   Loomans CJM, 2004, DIABETES, V53, P195, DOI 10.2337/diabetes.53.1.195
   MARLETTA MA, 1993, J BIOL CHEM, V268, P12231
   Mather KJ, 2001, J AM COLL CARDIOL, V37, P1344, DOI 10.1016/S0735-1097(01)01129-9
   Meigs JB, 2006, DIABETES, V55, P530, DOI 10.2337/diabetes.55.02.06.db05-1041
   MONCADA S, 1988, BIOCHEM PHARMACOL, V37, P2495, DOI 10.1016/0006-2952(88)90236-5
   Monnier L, 2006, JAMA-J AM MED ASSOC, V295, P1681, DOI 10.1001/jama.295.14.1681
   Naruse K, 2006, DIABETES, V55, P691, DOI 10.2337/diabetes.55.03.06.db05-0771
   Nissen SE, 2007, NEW ENGL J MED, V356, P2457, DOI 10.1056/NEJMoa072761
   Ouchi N, 1999, CIRCULATION, V100, P2473, DOI 10.1161/01.CIR.100.25.2473
   Papaharalambus CA, 2007, TRENDS CARDIOVAS MED, V17, P48, DOI 10.1016/j.tcm.2006.11.005
   Pitkänen OP, 1998, DIABETES, V47, P248, DOI 10.2337/diabetes.47.2.248
   Rask-Madsen C, 2007, NAT CLIN PRACT ENDOC, V3, P46, DOI 10.1038/ncpendmet0366
   Schiekofer S, 2003, DIABETES OBES METAB, V5, P251, DOI 10.1046/j.1463-1326.2003.00270.x
   Scognamiglio R, 2006, DIABETES CARE, V29, P95, DOI 10.2337/diacare.29.1.95
   Scognamiglio R, 2005, CIRCULATION, V112, P179, DOI 10.1161/CIRCULATIONAHA.104.495127
   Son NH, 2007, J CLIN INVEST, V117, P2791, DOI 10.1172/JCI30335
   Sporbert A, 1999, MOL BRAIN RES, V67, P258, DOI 10.1016/S0169-328X(99)00067-4
   Stump Craig S, 2005, Treat Endocrinol, V4, P343, DOI 10.2165/00024677-200504060-00003
   Tepper OM, 2002, CIRCULATION, V106, P2781, DOI 10.1161/01.CIR.0000039526.42991.93
   Title LM, 2000, J AM COLL CARDIOL, V36, P2185, DOI 10.1016/S0735-1097(00)00980-3
   Ueba H, 2005, ATHEROSCLEROSIS, V183, P35, DOI 10.1016/j.atherosclerosis.2005.01.055
   Vasa M, 2001, CIRC RES, V89, pE1, DOI 10.1161/hh1301.093953
   VILLANUEVA FS, 1993, CIRCULATION, V88, P2596, DOI 10.1161/01.CIR.88.6.2596
   VILLANUEVA FS, 1993, CIRCULATION, V88, P596, DOI 10.1161/01.CIR.88.2.596
   Vinik A, 2006, VASC PHARMACOL, V45, P54, DOI 10.1016/j.vph.2005.11.012
   Vladimirova O, 1999, INFLAMM RES, V48, P412, DOI 10.1007/s000110050480
   Weyer C, 2002, ATHEROSCLEROSIS, V161, P233, DOI 10.1016/S0021-9150(01)00626-8
   Yki-Järvinen H, 2003, BEST PRACT RES CL EN, V17, P411, DOI 10.1016/S1521-690X(03)00033-2
   Zhu WL, 2007, EUR J APPL PHYSIOL, V99, P585, DOI 10.1007/s00421-006-0378-3
   Zimmet P, 1999, ANN NY ACAD SCI, V892, P25, DOI 10.1111/j.1749-6632.1999.tb07783.x
NR 53
TC 69
Z9 80
U1 0
U2 11
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD DEC 15
PY 2008
VL 82
SU 2
BP S94
EP S101
DI 10.1016/j.diabres.2008.09.021
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 390CG
UT WOS:000262141300003
PM 18954919
DA 2025-06-11
ER

PT J
AU Patil, T
   Bernard, B
AF Patil, Tejas
   Bernard, Brandon
TI Complications of Androgen Deprivation Therapy in Men With Prostate
   Cancer
SO ONCOLOGY-NEW YORK
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; QUALITY-OF-LIFE; COGNITIVE FUNCTION;
   JAPANESE PATIENTS; ZOLEDRONIC ACID; HOT FLASHES; BONE LOSS; RISK;
   BRACHYTHERAPY; GYNECOMASTIA
AB The standard treatment for men with metastatic prostate cancer is androgen deprivation therapy (ADT). This therapy is associated with a multitude of side effects that can impact quality of life. These include vasomotor complications (in particular, hot flushes), sexual dysfunction and gynecomastia, osteoporosis, metabolic syndrome, and depression. Additionally, ADT has been associated with neurocognitive deficits, thromboembolic disease, and cardiovascular disease, although the data regarding the latter associations are mixed. This article summarizes the key side effects associated with ADT and discusses strategies to optimize management.
C1 [Patil, Tejas] Univ Colorado, Sch Med, Hematol & Oncol Fellowship Program, Div Med Oncol, Aurora, CO 80045 USA.
   [Bernard, Brandon] Univ Colorado, Sch Med, Div Med Oncol, Aurora, CO USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; University of Colorado System; University of Colorado Anschutz
   Medical Campus
RP Patil, T (corresponding author), Univ Colorado, Sch Med, Hematol & Oncol Fellowship Program, Div Med Oncol, Aurora, CO 80045 USA.
RI Patil, Tejas/AEU-9465-2022
OI Patil, Tejas/0000-0003-4389-1010
CR Alemozaffar M, 2011, JAMA-J AM MED ASSOC, V306, P1205, DOI 10.1001/jama.2011.1333
   Alibhai SMH, 2010, J CLIN ONCOL, V28, P5030, DOI 10.1200/JCO.2010.30.8742
   Baik SH, 2017, J CLIN ONCOL, V35, P3401, DOI 10.1200/JCO.2017.72.6109
   Beer TM, 2010, UROLOGY, V76, P1182, DOI 10.1016/j.urology.2010.03.033
   Bosco C, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0117344
   Braga-Basaria M, 2006, J CLIN ONCOL, V24, P3979, DOI 10.1200/JCO.2006.05.9741
   Braunstein LZ., 2014, PROSTATE CANCER, V2014, P6, DOI [10.1155/2014/230812, DOI 10.1155/2014/230812]
   Chang D, 2014, J MED IMAG RADIAT ON, V58, P223, DOI 10.1111/1754-9485.12124
   Cherrier MM, 2001, NEUROLOGY, V57, P80, DOI 10.1212/WNL.57.1.80
   Chung SD, 2012, BJU INT, V109, P1001, DOI 10.1111/j.1464-410X.2011.10459.x
   Ehdaie B, 2012, CANCER-AM CANCER SOC, V118, P3397, DOI 10.1002/cncr.26623
   Ferrer M, 2008, INT J RADIAT ONCOL, V72, P421, DOI 10.1016/j.ijrobp.2007.12.024
   Fizazi K, 2011, LANCET, V377, P813, DOI 10.1016/S0140-6736(10)62344-6
   Gandaglia G, 2014, EUR UROL, V66, P1125, DOI 10.1016/j.eururo.2014.01.026
   Gay HA, 2017, INT J RADIAT ONCOL, V98, P304, DOI 10.1016/j.ijrobp.2017.02.019
   Golla V, 2017, CURR UROL REP, V18, DOI 10.1007/s11934-017-0695-6
   Green HJ, 2002, BJU INT, V90, P427, DOI 10.1046/j.1464-410X.2002.02917.x
   Higano CS, 2003, UROL ONCOL-SEMIN ORI, V21, P392, DOI 10.1016/S1078-1439(03)00143-1
   Holzbeierlein JM, 2004, CURR OPIN UROL, V14, P177, DOI 10.1097/00042307-200405000-00007
   Irani J, 2010, LANCET ONCOL, V11, P147, DOI 10.1016/S1470-2045(09)70338-9
   Kim HS, 2011, BJU INT, V107, P924, DOI 10.1111/j.1464-410X.2010.09679.x
   Lapi F, 2013, JAMA-J AM MED ASSOC, V310, P289, DOI 10.1001/jama.2013.8638
   Loprinzi CL, 2009, ANN ONCOL, V20, P542, DOI 10.1093/annonc/mdn644
   Meng FZ, 2016, BMC CANCER, V16, DOI 10.1186/s12885-016-2221-5
   Mitsuzuka K, 2016, PROSTATE CANCER P D, V19, P57, DOI 10.1038/pcan.2015.50
   Nead KT, 2017, JAMA ONCOL, V3, P49, DOI 10.1001/jamaoncol.2016.3662
   Nguyen PL, 2015, EUR UROL, V67, P825, DOI 10.1016/j.eururo.2014.07.010
   Saad F, 2002, JNCI-J NATL CANCER I, V94, P1458, DOI 10.1093/jnci/94.19.1458
   Saigal CS, 2007, CANCER-AM CANCER SOC, V110, P1493, DOI 10.1002/cncr.22933
   Salvador C, 2013, UROL INT, V90, P41, DOI 10.1159/000342814
   Sartor O, 2018, NEW ENGL J MED, V378, P645, DOI 10.1056/NEJMra1701695
   Seible DM, 2014, UROLOGY, V83, P1316, DOI 10.1016/j.urology.2014.02.006
   Shahinian VB, 2006, ARCH INTERN MED, V166, P465
   Shahinian VB, 2005, NEW ENGL J MED, V352, P154, DOI 10.1056/NEJMoa041943
   Shanafelt TD, 2002, MAYO CLIN PROC, V77, P1207, DOI 10.4065/77.11.1207
   Sharifi N, 2005, JAMA-J AM MED ASSOC, V294, P238, DOI 10.1001/jama.294.2.238
   Smith J A Jr, 1996, Oncology (Williston Park), V10, P1319
   Smith Jr JA, 1996, ONCOLOGY WILLISTON P, V10, P24
   Smith MR, 2014, J CLIN ONCOL, V32, P1143, DOI 10.1200/JCO.2013.51.6500
   Smith MR, 2001, NEW ENGL J MED, V345, P948, DOI 10.1056/NEJMoa010845
   Sun M, 2018, J UROLOGY, V199, P1418, DOI 10.1016/j.juro.2017.11.136
   Torimoto K, 2011, JPN J CLIN ONCOL, V41, P577, DOI 10.1093/jjco/hyr005
   Tunio MA, 2012, CURR ONCOL, V19, pE280, DOI 10.3747/co.19.993
   Viani GA, 2012, INT J RADIAT ONCOL, V83, pE519, DOI 10.1016/j.ijrobp.2012.01.036
   Winters-Stone KM, 2017, J AM GERIATR SOC, V65, P1414, DOI 10.1111/jgs.14795
   Yang J, 2015, EUR J CANCER CARE, V24, P198, DOI 10.1111/ecc.12299
NR 46
TC 16
Z9 17
U1 0
U2 6
PU UBM MEDICA
PI NORWALK
PA 535 CONNECTICUT AVE, STE 300, NORWALK, CT 06854 USA
SN 0890-9091
J9 ONCOLOGY-NY
JI Oncology-NY
PD SEP
PY 2018
VL 32
IS 9
BP 470
EP 475
PG 6
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA GU1KJ
UT WOS:000445019500007
PM 30248169
DA 2025-06-11
ER

PT J
AU Ward, MC
   White, DT
   Druss, BG
AF Ward, Martha C.
   White, DeJuan T.
   Druss, Benjamin G.
TI A Meta-Review of Lifestyle Interventions for Cardiovascular Risk Factors
   in the General Medical Population: Lessons for Individuals With Serious
   Mental Illness
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Review
ID IMPAIRED GLUCOSE-TOLERANCE; BLOOD-PRESSURE CONTROL; PHYSICAL-ACTIVITY;
   WEIGHT-LOSS; BEHAVIORAL INTERVENTIONS; MANAGEMENT; PEOPLE; PREVENTION;
   OBESITY; EXERCISE
AB Objective: Individuals with serious mental illness die years younger than members of the general population, with cardiovascular disease and related risk factors accounting for the majority of deaths. Lifestyle interventions targeting these risk factors have begun to be developed for those with serious mental illness, but they have largely been created de novo rather than with information from work already done in the general population. This review aims to synthesize for a mental health audience the common factors for success in nonpharmacologic lifestyle interventions and identify specific considerations in adapting these models for those with serious mental illness.
   Data Sources: We searched the PubMed and Cochrane databases for English-language reviews from 2003 to 2013. The search employed combinations of the following terms: diabetes, diabetes mellitus, hypertension, hyperlipidemia, dyslipidemia, obesity, mental illness, schizophrenia, psychosis, bipolar disorder, lifestyle intervention, nonpharmacologic intervention, lifestyle modification, and weight gain.
   Study Selection: We identified 8,147 review articles from the PubMed and Cochrane databases. 123 articles were selected. The selected articles were reviews of dietary, behavioral, or exercise interventions that focused on obesity and related cardiometabolic risk factors.
   Data Extraction: We undertook a qualitative "review of reviews" focusing on nonpharmacologic interventions for obesity and related cardiometabolic risk factors.
   Results: Effects of interventions in the general population were meaningful but generally modest. Specific elements of diet, exercise, and behavioral therapy produced larger effects. Additionally, successful programs employed multiple components, personalization, longer duration, more frequent contact, and trained treatment providers. Interventions addressing these risk factors in people with serious mental illness typically incorporated some, but not all, of the elements demonstrated to be effective in general medical populations.
   Conclusions: Studies from the general medical literature demonstrate considerable promise in addressing lifestyle risk factors. Existing programs will require tailoring to address the needs of those with serious mental illness and may be harder to implement given the challenges faced by this population. However, successful lifestyle interventions for those with serious mental illness can make a significant impact on the health and well-being of this vulnerable population and may inform future strategies for other underserved groups. (C) Copyright 2015 Physicians Postgraduate Press, Inc.
C1 [Ward, Martha C.; White, DeJuan T.] Emory Univ, Dept Gen Med, Dept Psychiat & Behav Sci, Rollins Sch Publ Hlth, Atlanta, GA 30303 USA.
   [Druss, Benjamin G.] Emory Univ, Dept Hlth Policy & Management, Rollins Sch Publ Hlth, Atlanta, GA 30303 USA.
C3 Emory University; Rollins School Public Health; Emory University;
   Rollins School Public Health
RP Ward, MC (corresponding author), Emory Univ, Dept Gen Med, Dept Psychiat & Behav Sci, 49 Jesse Hill Jr Dr SE,Ste 231, Atlanta, GA 30303 USA.
EM mcraig@emory.edu
RI White, DeJuan/GLU-4112-2022
FU Fitzgerald Foundation of Atlanta, Georgia; K24 award
FX Partial funding for this article was provided by a K24 award to Dr Druss
   and by a grant from the Fitzgerald Foundation of Atlanta, Georgia, to Dr
   Ward.
CR Ali MK, 2012, HEALTH AFFAIR, V31, P67, DOI 10.1377/hlthaff.2011.1009
   Alvarez-Jiménez M, 2008, BRIT J PSYCHIAT, V193, P101, DOI 10.1192/bjp.bp.107.042853
   [Anonymous], 2012, HEALTH TECHNOL ASSES, DOI DOI 10.3310/hta16330
   Artinian NT, 2010, CIRCULATION, V122, P406, DOI 10.1161/CIR.0b013e3181e8edf1
   Baker Elizabeth A, 2006, Prev Chronic Dis, V3, pA76
   Baker MK, 2011, DIABETES RES CLIN PR, V91, P1, DOI 10.1016/j.diabres.2010.06.030
   Bauer MS, 2005, INT J PSYCHIAT MED, V35, P13, DOI 10.2190/U1D5-8B1D-UW69-U1Y4
   Beilin LJ, 2004, CLIN EXP HYPERTENS, V26, P739, DOI 10.1081/CEH-200032148
   Bonfioli E, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-78
   Bradshaw T, 2005, J ADV NURS, V49, P634, DOI 10.1111/j.1365-2648.2004.03338.x
   Brown T, 2009, OBES REV, V10, P627, DOI 10.1111/j.1467-789X.2009.00641.x
   Cabassa LJ, 2010, PSYCHIAT SERV, V61, P774, DOI 10.1176/ps.2010.61.8.774
   Champagne CM, 2009, CURR DIABETES REP, V9, P389, DOI 10.1007/s11892-009-0060-3
   Compton MT, 2006, HARVARD REV PSYCHIAT, V14, P212, DOI 10.1080/10673220600889256
   Curioni CC, 2005, INT J OBESITY, V29, P1168, DOI 10.1038/sj.ijo.0803015
   Das Chandan, 2012, Ann Clin Psychiatry, V24, P225
   Daumit GL, 2013, NEW ENGL J MED, V368, P1594, DOI 10.1056/NEJMoa1214530
   Hert M, 2012, NAT REV ENDOCRINOL, V8, P114, DOI 10.1038/nrendo.2011.156
   Dickinson HO, 2006, J HYPERTENS, V24, P215, DOI 10.1097/01.hjh.0000199800.72563.26
   Druss BG, 2011, MED CARE, V49, P599, DOI 10.1097/MLR.0b013e31820bf86e
   Eyles HC, 2009, NUTR REV, V67, P464, DOI 10.1111/j.1753-4887.2009.00219.x
   Fagard RH, 2007, EUR J CARDIOV PREV R, V14, P12, DOI 10.1097/HJR.0b013e3280128bbb
   Faulkner G, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005148.pub2
   Faulkner G, 2006, CAN J PSYCHIAT, V51, P502, DOI 10.1177/070674370605100805
   Gabriele JM, 2009, OBES REV, V10, P442, DOI 10.1111/j.1467-789X.2009.00570.x
   Galani C, 2007, INT J PUBLIC HEALTH, V52, P348, DOI 10.1007/s00038-007-7015-8
   Galletly Carol L, 2009, Issues Ment Health Nurs, V30, P660
   Ganguli R, 2007, J CLIN PSYCHIAT, V68, P19, DOI 10.4088/JCP.0607e14
   Gierisch J.M., 2013, Interventions To Improve Cardiovascular Risk Factors in People With Serious Mental Illness
   Gillies CL, 2007, BMJ-BRIT MED J, V334, P299, DOI 10.1136/bmj.39063.689375.55
   Hedayati SS, 2011, KIDNEY INT, V79, P1061, DOI 10.1038/ki.2011.46
   Jakicic JM, 2011, PSYCHIAT CLIN N AM, V34, P829, DOI 10.1016/j.psc.2011.08.009
   Johnson M, 2011, DIABETES RES CLIN PR, V93, P150, DOI 10.1016/j.diabres.2011.06.004
   Katz DL, 2005, ANNU REV PUBL HEALTH, V26, P61, DOI 10.1146/annurev.publhealth.26.021304.144415
   Kavookjian J, 2007, DIABETES EDUCATOR, V33, P962, DOI 10.1177/0145721707308411
   Kemp V, 2009, CURR OPIN PSYCHIATR, V22, P194, DOI 10.1097/YCO.0b013e328325a585
   Kilbourne AM, 2006, INT J PSYCHIAT MED, V36, P383, DOI 10.2190/04XR-3107-4004-4670
   Kirk SFL, 2012, INT J OBESITY, V36, P178, DOI 10.1038/ijo.2011.80
   Kodama S, 2007, ARCH INTERN MED, V167, P999, DOI 10.1001/archinte.167.10.999
   Kokkinos P, 2005, J CLIN HYPERTENS, V7, P171
   Kokkinos Peter, 2005, J Clin Hypertens (Greenwich), V7, P165, DOI 10.1111/j.1524-6175.2005.04079.x
   Lee LL, 2010, INT J NURS STUD, V47, P1545, DOI 10.1016/j.ijnurstu.2010.08.008
   Lester H, 2003, FAM PRACT, V20, P508, DOI 10.1093/fampra/cmg502
   Leung CW, 2012, AM J CLIN NUTR, V96, P977, DOI 10.3945/ajcn.112.040014
   Lloyd-Jones D, 2009, CIRCULATION, V119, pE21, DOI 10.1161/CIRCULATIONAHA.108.191261
   Loh Catherine, 2006, Ann Clin Psychiatry, V18, P23, DOI 10.1080/10401230500464646
   Lowe T, 2008, J PSYCHIATR MENT HLT, V15, P857, DOI 10.1111/j.1365-2850.2008.01337.x
   Mastellos N, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008066.pub3
   McCabe Marita P, 2008, Psychol Health Med, V13, P303, DOI 10.1080/13548500701473952
   McCreadie RG, 2003, BRIT J PSYCHIAT, V183, P534, DOI 10.1192/bjp.183.6.534
   Nield L, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004097.pub4
   Orozco LJ, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003054.pub3
   Osborn DPJ, 2007, SOC PSYCH PSYCH EPID, V42, P787, DOI 10.1007/s00127-007-0247-3
   Osei-Assibey G, 2010, OBES REV, V11, P769, DOI 10.1111/j.1467-789X.2009.00695.x
   PATE RR, 1995, JAMA-J AM MED ASSOC, V273, P402, DOI 10.1001/jama.273.5.402
   Paul-Ebhohimhen V, 2009, OBESITY FACTS, V2, P17, DOI 10.1159/000186144
   Priebe MG, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006061.pub2
   Ratner Robert E, 2006, Endocr Pract, V12 Suppl 1, P20
   Reichenberg A, 2009, SCHIZOPHRENIA BULL, V35, P1022, DOI 10.1093/schbul/sbn044
   Roberts SH, 2011, J ADV NURS, V67, P690, DOI 10.1111/j.1365-2648.2010.05546.x
   Ross R, 2000, Exerc Sport Sci Rev, V28, P165
   Saraceno Benedetto, 2005, World Psychiatry, V4, P181
   Satterfield DW, 2003, DIABETES CARE, V26, P2643, DOI 10.2337/diacare.26.9.2643
   Seo DC, 2008, PREV MED, V47, P573, DOI 10.1016/j.ypmed.2007.12.010
   Sharma M, 2007, OBES REV, V8, P441, DOI 10.1111/j.1467-789X.2007.00351.x
   Shaw K, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003817.pub3
   Shaw K, 2005, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003818.pub2
   Smith V, 2011, BMC MED RES METHODOL, V11, P15
   Steyn NP, 2009, P NUTR SOC, V68, P55, DOI 10.1017/S0029665108008823
   Stone NJ, 2008, AM J CARDIOL, V102, p14L, DOI 10.1016/j.amjcard.2008.09.069
   Thomas DR, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002968.pub2
   Thomas D, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006296.pub2
   Van Dorsten B, 2011, MED CLIN N AM, V95, P971, DOI 10.1016/j.mcna.2011.06.008
   Venditti EM, 2012, CURR DIABETES REP, V12, P138, DOI 10.1007/s11892-012-0256-9
   Verhaeghe N, 2011, INT J BEHAV NUTR PHY, V8, DOI 10.1186/1479-5868-8-28
   Wadden TA, 2007, GASTROENTEROLOGY, V132, P2226, DOI 10.1053/j.gastro.2007.03.051
   Wadden TA, 2012, CIRCULATION, V125, P1157, DOI 10.1161/CIRCULATIONAHA.111.039453
   Wieland LS, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007675.pub2
   Yoon U, 2013, METABOLISM, V62, P303, DOI 10.1016/j.metabol.2012.07.009
   Yu-Poth S, 1999, AM J CLIN NUTR, V69, P632
NR 80
TC 84
Z9 85
U1 0
U2 28
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD APR
PY 2015
VL 76
IS 4
BP E477
EP +
DI 10.4088/JCP.13r08657
PG 36
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA CI8DA
UT WOS:000354997500002
PM 25919840
DA 2025-06-11
ER

PT J
AU Carvajal, SC
   Huang, S
   Bell, ML
   Denman, C
   de Zapien, JG
   Cornejo, E
   Chang, J
   Staten, LK
   Rosales, C
AF Carvajal, S. C.
   Huang, S.
   Bell, M. L.
   Denman, C.
   de Zapien, J. Guernsey
   Cornejo, E.
   Chang, J.
   Staten, L. K.
   Rosales, C.
TI Behavioral and subjective health changes in US and Mexico border
   residing participants in two promotora-led chronic disease preventive
   interventions
SO HEALTH EDUCATION RESEARCH
LA English
DT Article
ID CARDIOMETABOLIC RISK; CARDIOVASCULAR RISK; PHYSICAL-ACTIVITY; COMMUNITY;
   WORKERS; CARE; REDUCTION; SALUD; AMERICANS; HISTORY
AB Chronic diseases are the primary health burden among Mexican-origin populations and health promotion efforts have not been able to change negative population trends. This research presents behavioral and subjective health impacts of two related community health worker (CHW) interventions conducted in the US-Mexico border region. Pasos Adelante (United States) and Meta Salud (Mexico) are 12-13 week CHW-led preventive interventions implemented with Mexico-origin adults. Curricula include active learning modules to promote healthy dietary changes and increasing physical activity; they also incorporate strategies to promote social support, empowerment and group exercise components responsive to their communities. Questionnaire data at baseline (N = 347 for Pasos; 171 for Meta Salud), program completion and 3-month follow-up were analyzed. Results showed statistically significant improvements in multiple reported dietary, physical activity and subjective health indicators. Furthermore, at follow-up across both cohorts there were >= 10% improvements in participants' meeting recommended physical activity guidelines, consumption of whole milk, days of poor mental health and self-rated health. While this study identifies some robust health improvements and contributes to the evidence base for these interventions current dissemination, the lack of change observed for some targeted behaviors (e.g. time sitting) suggests they may have stronger overall impacts with curricula refinement.
C1 [Carvajal, S. C.; de Zapien, J. Guernsey; Chang, J.] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Hlth Promot Sci, 1295 N Martin Ave, Tucson, AZ 85724 USA.
   [Carvajal, S. C.] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Arizona Prevent Res Ctr, 1295 N Martin Ave, Tucson, AZ 85724 USA.
   [Huang, S.; Bell, M. L.] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Epidemiol & Biostat, 1295 N Martin Ave, Tucson, AZ 85724 USA.
   [Denman, C.; Cornejo, E.] El Colegio Sonora, Ctr Estudios Salud & Soc, Hermosillo, Sonora, Mexico.
   [Staten, L. K.] Indiana Univ, Richard M Fairbanks Sch Publ Hlth, Social & Behav Sci, 1050 Wishard Blvd,RG 6048, Indianapolis, IN 46202 USA.
   [Rosales, C.] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Div Publ Hlth Practice & Translat Res, 714 E Van Buren St,Bldg 4,UA Phoenix Plaza 119G, Phoenix, AZ 85006 USA.
C3 University of Arizona; University of Arizona; University of Arizona;
   Indiana University System; Indiana University Indianapolis; University
   of Arizona
RP Carvajal, SC (corresponding author), Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Hlth Promot Sci, 1295 N Martin Ave, Tucson, AZ 85724 USA.; Carvajal, SC (corresponding author), Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Arizona Prevent Res Ctr, 1295 N Martin Ave, Tucson, AZ 85724 USA.
EM scott.carvajal@arizona.edu
RI ; Bell, Melanie/D-1839-2011
OI Staten, Lisa/0000-0002-6056-4153; Bell, Melanie/0000-0003-4821-4094
FU National Center for Chronic Disease Prevention and Health Promotion,
   Centers for Disease Control and Prevention, United States Department of
   Health and Human Services [U48DP005002, U48-DP000041]; UnitedHealth
   Chronic Disease Initiative; National Heart, Lung and Blood Institute,
   National Institutes of Health [R01HL125996]
FX This work was supported by the National Center for Chronic Disease
   Prevention and Health Promotion, Centers for Disease Control and
   Prevention, United States Department of Health and Human Services
   (U48DP005002 to S.C.C, U48-DP000041 to L.K.S.); UnitedHealth Chronic
   Disease Initiative (to C.D.) and the National Heart, Lung and Blood
   Institute, National Institutes of Health (R01HL125996 to C.R.).
CR [Anonymous], PAS AD CURR
   [Anonymous], ENC NAC SAL NUTR ENS
   [Anonymous], MET SAL
   [Anonymous], NOT ACC NUTR PHYS AC
   [Anonymous], NIH PUBLICATION
   Ayala GX, 2011, AM J PUBLIC HEALTH, V101, P2261, DOI 10.2105/AJPH.2011.300273
   Ayala GX, 2010, HEALTH EDUC RES, V25, P815, DOI 10.1093/her/cyq035
   Balcazar H, 2018, AM J PUBLIC HEALTH, V108, P720, DOI 10.2105/AJPH.2018.304427
   Balcazar H, 2016, J AMBUL CARE MANAG, V39, P12, DOI 10.1097/JAC.0000000000000096
   Balcázar H, 2015, PREV CHRONIC DIS, V12, DOI 10.5888/pcd12.140292
   Balcázar HG, 2010, PREV CHRONIC DIS, V7
   Bandura A, 2004, HEALTH EDUC BEHAV, V31, P143, DOI 10.1177/1090198104263660
   Barquera S, 2015, ARCH MED RES, V46, P328, DOI 10.1016/j.arcmed.2015.06.006
   Bell ML, 2014, STAT METHODS MED RES, V23, P440, DOI 10.1177/0962280213476378
   Bouchonville M, 2014, INT J OBESITY, V38, P423, DOI 10.1038/ijo.2013.122
   Canudas-Romo V, 2015, J EPIDEMIOL COMMUN H, V69, P28, DOI 10.1136/jech-2014-204237
   Carvajal SC, 2013, INT J ENV RES PUB HE, V10, P4701, DOI 10.3390/ijerph10104701
   Centers for Disease Control and Prevention, 2017, BEH RISK FACT SURV S
   Cutshaw Christina A, 2012, Prev Chronic Dis, V9, pE24
   de Heer HD, 2015, FRONT PUBLIC HEALTH, V3, DOI 10.3389/fpubh.2015.00149
   Denman CA, 2015, GLOB HEART, V10, P55, DOI 10.1016/j.gheart.2014.12.007
   Denman CA, 2014, PREV CHRONIC DIS, V11, DOI 10.5888/pcd11.140218
   Des Jarlais DC, 2004, AM J PUBLIC HEALTH, V94, P361, DOI 10.2105/AJPH.94.3.361
   Elder JP, 2013, AM J PREV MED, V44, P526, DOI 10.1016/j.amepre.2013.02.005
   Flores YN, 2015, QUAL LIFE RES, V24, P1887, DOI 10.1007/s11136-015-0922-x
   Fort MP, 2015, BMC HEALTH SERV RES, V15, DOI 10.1186/s12913-015-1248-7
   Gallegos-Carrillo K, 2013, HEALTH PSYCHOL, V32, P609, DOI 10.1037/a0029276
   Hernandez R, 2016, DIABETES EDUCATOR, V42, P452, DOI 10.1177/0145721716654008
   Horton LA, 2018, HEALTH EDUC BEHAV, V45, P501, DOI 10.1177/1090198117742439
   Huang S, 2016, CLIN TRIALS, V13, P445, DOI 10.1177/1740774516643498
   Islam N, 2015, J PUBLIC HEALTH MAN, V21, P42, DOI 10.1097/PHH.0000000000000084
   Koniak-Griffin D, 2015, INT J NURS STUD, V52, P75, DOI 10.1016/j.ijnurstu.2014.09.005
   Koskan AM, 2013, HEALTH PROMOT PRACT, V14, P390, DOI 10.1177/1524839912457176
   Krantz MJ, 2017, AM J PREV MED, V53, pE71, DOI 10.1016/j.amepre.2017.04.012
   McLeroy KR, 2016, HEALTH EDUC BEHAV, V43, P501, DOI 10.1177/1090198116668522
   Meneses-Leon J, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-446
   Mudd-Martin G, 2013, PREV CHRONIC DIS, V10, DOI 10.5888/pcd10.130137
   Neupane D, 2018, LANCET GLOB HEALTH, V6, pE66, DOI 10.1016/s2214-109x(17)30411-4
   Oyebode O, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0122747
   Palloni A, 2015, SALUD PUBLICA MEXICO, V57, pS22
   Pérez-Zepeda MU, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0153855
   Perry HB, 2014, ANNU REV PUBL HEALTH, V35, P399, DOI 10.1146/annurev-publhealth-032013-182354
   Ramirez AG, 2013, HEALTH EDUC RES, V28, P745, DOI 10.1093/her/cyt089
   Reininger BM, 2015, BMC PUBLIC HEALTH, V15, DOI 10.1186/s12889-015-1850-y
   Rothschild SK, 2014, AM J PUBLIC HEALTH, V104, P1540, DOI 10.2105/AJPH.2013.301439
   Staten L.K., 2012, Preventing Chronic Disease, V9, P100301, DOI [DOI 10.5888/PCD9.100301, 10.5888/pcd9.100301]
   Staten Lisa K, 2005, Prev Chronic Dis, V2, pA18
   Wang XH, 2012, POPUL HEALTH MANAG, V15, P90, DOI 10.1089/pop.2010.0085
   Wilson KJ, 2015, HEALTH PROMOT PRACT, V16, P101, DOI 10.1177/1524839914537274
NR 49
TC 4
Z9 4
U1 1
U2 11
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0268-1153
EI 1465-3648
J9 HEALTH EDUC RES
JI Health Educ. Res.
PD DEC
PY 2018
VL 33
IS 6
BP 522
EP 534
DI 10.1093/her/cyy037
PG 13
WC Education & Educational Research; Public, Environmental & Occupational
   Health
WE Social Science Citation Index (SSCI)
SC Education & Educational Research; Public, Environmental & Occupational
   Health
GA HI8EN
UT WOS:000456688200006
PM 30358830
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Jubaidi, FF
   Zainalabidin, S
   Taib, IS
   Abd Hamid, Z
   Budin, SB
AF Jubaidi, Fatin Farhana
   Zainalabidin, Satirah
   Taib, Izatus Shima
   Hamid, Zariyantey Abd
   Budin, Siti Balkis
TI The Potential Role of Flavonoids in Ameliorating Diabetic Cardiomyopathy
   via Alleviation of Cardiac Oxidative Stress, Inflammation and Apoptosis
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE diastolic dysfunction; flavone; flavonol; flavanol; isoflavone; systolic
   dysfunction
ID CARDIOMETABOLIC RISK-FACTORS; PROTEIN-KINASE-C; CELL-DEATH;
   DOUBLE-BLIND; MOLECULAR-MECHANISMS; INSULIN-RESISTANCE; HEART-FAILURE;
   RICH EXTRACT; IN-VITRO; HYPERTROPHY
AB Diabetic cardiomyopathy is one of the major mortality risk factors among diabetic patients worldwide. It has been established that most of the cardiac structural and functional alterations in the diabetic cardiomyopathy condition resulted from the hyperglycemia-induced persistent oxidative stress in the heart, resulting in the maladaptive responses of inflammation and apoptosis. Flavonoids, the most abundant phytochemical in plants, have been reported to exhibit diverse therapeutic potential in medicine and other biological activities. Flavonoids have been widely studied for their effects in protecting the heart against diabetes-induced cardiomyopathy. The potential of flavonoids in alleviating diabetic cardiomyopathy is mainly related with their remedial actions as anti-hyperglycemic, antioxidant, anti-inflammatory, and anti-apoptotic agents. In this review, we summarize the latest findings of flavonoid treatments on diabetic cardiomyopathy as well as elucidating the mechanisms involved.
C1 [Jubaidi, Fatin Farhana; Taib, Izatus Shima; Hamid, Zariyantey Abd; Budin, Siti Balkis] Univ Kebangsaan Malaysia, Ctr Diagnost Therapeut & Investigat Studies, Fac Hlth Sci, Kuala Lumpur 50300, Malaysia.
   [Zainalabidin, Satirah] Univ Kebangsaan Malaysia, Fac Hlth Sci, Ctr Toxicol & Hlth Risk Studies, Kuala Lumpur 50300, Malaysia.
C3 Universiti Kebangsaan Malaysia; Universiti Kebangsaan Malaysia
RP Budin, SB (corresponding author), Univ Kebangsaan Malaysia, Ctr Diagnost Therapeut & Investigat Studies, Fac Hlth Sci, Kuala Lumpur 50300, Malaysia.
EM fatinfarhanajubaidi@gmail.com; satirah@ukm.edu.my;
   izatusshima@ukm.edu.my; zyantey@ukm.edu.my; balkis@ukm.edu.my
RI Budin, Siti Balkis/ABB-8820-2021; Jubaidi, Fatin/G-7269-2016
OI Taib, Izatus Shima/0000-0001-9901-766X
FU Ministry of Education Malaysia [FRGS/1/2019/STG03/UKM/01/3]
FX This research was funded by the Ministry of Education Malaysia, grant
   number FRGS/1/2019/STG03/UKM/01/3.
CR Abdul Y, 2019, MOL NEUROBIOL, V56, P1607, DOI 10.1007/s12035-018-1184-8
   Al-Rasheed NM, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/1092015
   Ali TM, 2020, AM J MED SCI, V359, P32, DOI 10.1016/j.amjms.2019.10.005
   Althunibat OY, 2019, LIFE SCI, V221, P83, DOI 10.1016/j.lfs.2019.02.017
   Anderson EJ, 2011, AM J PHYSIOL-HEART C, V300, pH118, DOI 10.1152/ajpheart.00932.2010
   Atta MS, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/7845681
   Bailly C, 2020, CHEM-BIOL INTERACT, V325, DOI 10.1016/j.cbi.2020.109124
   Baker RG, 2011, CELL METAB, V13, P11, DOI 10.1016/j.cmet.2010.12.008
   Barreca D, 2017, BIOFACTORS, V43, P495, DOI 10.1002/biof.1363
   Borghetti G, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01514
   Calabró V, 2018, ARCH BIOCHEM BIOPHYS, V647, P47, DOI 10.1016/j.abb.2018.03.041
   Capomolla AS, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061271
   Carresi C, 2018, J MOL CELL CARDIOL, V119, P10, DOI 10.1016/j.yjmcc.2018.04.007
   Castillo RL, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/7239123
   Chen YF, 2016, J NUTR BIOCHEM, V31, P98, DOI 10.1016/j.jnutbio.2015.12.020
   Chen Y, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00042
   Cleland SJ, 2013, DIABETOLOGIA, V56, P1462, DOI 10.1007/s00125-013-2904-2
   Curtis PJ, 2019, AM J CLIN NUTR, V109, P1535, DOI 10.1093/ajcn/nqy380
   Curtis PJ, 2012, DIABETES CARE, V35, P226, DOI 10.2337/dc11-1443
   D'Arcy MS, 2019, CELL BIOL INT, V43, P582, DOI 10.1002/cbin.11137
   Davargaon RS, 2019, IUBMB LIFE, V71, P1876, DOI 10.1002/iub.2133
   Diaz-Meco MT, 2012, IMMUNOL REV, V246, P154, DOI 10.1111/j.1600-065X.2012.01093.x
   Dikalov SI, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00907
   Duarte S, 2013, INT J MOL SCI, V14, P17664, DOI 10.3390/ijms140917664
   Dudylina AL, 2019, CELL BIOCHEM BIOPHYS, V77, P99, DOI 10.1007/s12013-018-0857-2
   Ebrahimpour-koujan S, 2018, PHYTOMEDICINE, V44, P39, DOI 10.1016/j.phymed.2018.03.050
   Eguchi K, 2008, AM J CARDIOL, V101, P1787, DOI 10.1016/j.amjcard.2008.02.082
   Einarson TR, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0728-6
   El Mouhayyar C, 2020, INT J ENDOCRINOL, V2020, DOI 10.1155/2020/1762164
   Falcao-Pires I, 2012, HEART FAIL REV, V17, P325, DOI 10.1007/s10741-011-9257-z
   Feng H, 2017, PLANTA MED, V83, P837, DOI 10.1055/s-0043-103415
   Fiorentino TV, 2013, CURR PHARM DESIGN, V19, P5695, DOI 10.2174/1381612811319320005
   Frangogiannis NG, 2019, CIRC RES, V125, P117, DOI 10.1161/CIRCRESAHA.119.311148
   Frieler RA, 2015, CIRCULATION, V131, P1019, DOI 10.1161/CIRCULATIONAHA.114.008788
   Gallo S, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20092164
   Gandhi GR, 2020, NUTRIENTS, V12, DOI 10.3390/nu12102907
   Garcia JP, 2018, REV CARDIOVASC MED, V19, P123, DOI 10.31083/j.rcm.2018.04.3187
   Ge ZD, 2019, INT HEART J, V60, P512, DOI 10.1536/ihj.18-476
   Geraldes P, 2010, CIRC RES, V106, P1319, DOI 10.1161/CIRCRESAHA.110.217117
   Gertz M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0049761
   Ghorbani A, 2017, BIOMED PHARMACOTHER, V96, P305, DOI 10.1016/j.biopha.2017.10.001
   Gil-Izquierdo A, 2002, J AGR FOOD CHEM, V50, P5107, DOI 10.1021/jf020162+
   Gliozzi M, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21207432
   Arbeláez LFG, 2016, J AGR FOOD CHEM, V64, P5180, DOI 10.1021/acs.jafc.6b01669
   Guimaraes JFC, 2015, CARDIOVASC DIABETOL, V14, DOI 10.1186/s12933-015-0255-7
   Gutiérrez-Salmeán G, 2016, INT J CARDIOL, V223, P500, DOI 10.1016/j.ijcard.2016.08.158
   Guzik TJ, 2002, CIRCULATION, V105, P1656, DOI 10.1161/01.CIR.0000012748.58444.08
   Harasstani OA, 2010, INFLAMM RES, V59, P711, DOI 10.1007/s00011-010-0182-8
   Herrero M., 2012, COMPREHENSIVE SAMPLI, P159, DOI DOI 10.1016/B978-0-12-381373-2.00132-0
   Hostetler GL, 2017, ADV NUTR, V8, P423, DOI 10.3945/an.116.012948
   Huang MLH, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/6392763
   Institute for Public Health (IPH), 2015, NON DIS RISK FACT OT, VII
   International Diabetes Federation, 2019, IDF Diabetes Atlas, V9th ed.
   Jia GH, 2018, CIRC RES, V122, P624, DOI 10.1161/CIRCRESAHA.117.311586
   Jia GH, 2016, NAT REV ENDOCRINOL, V12, P144, DOI 10.1038/nrendo.2015.216
   Jia Qiang, 2019, Zhong Nan Da Xue Xue Bao Yi Xue Ban, V44, P850, DOI 10.11817/j.issn.1672-7347.2019.08.180429
   Jiang N, 2016, PLANTS-BASEL, V5, DOI 10.3390/plants5020027
   Jubaidi FF, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21176043
   Kayacan S, 2021, ANTICANCER RES, V41, P1271, DOI 10.21873/anticanres.14884
   Kenny HC, 2019, CIRC RES, V124, P121, DOI 10.1161/CIRCRESAHA.118.311371
   Khoo HE, 2017, FOOD NUTR RES, V61, P1, DOI 10.1080/16546628.2017.1361779
   Kim HJ, 2005, J IMMUNOL, V175, P2948, DOI 10.4049/jimmunol.175.5.2948
   Krízová L, 2019, MOLECULES, V24, DOI 10.3390/molecules24061076
   Kumar S, 2013, SCI WORLD J, DOI 10.1155/2013/162750
   Li L, 2019, PHYTOMEDICINE, V59, DOI 10.1016/j.phymed.2018.11.034
   Liao HH, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/8370593
   Lim YC, 2017, CARDIOVASC TOXICOL, V17, P251, DOI 10.1007/s12012-016-9379-6
   Liu J, 2014, FREE RADICAL RES, V48, P898, DOI 10.3109/10715762.2014.920955
   Liu Y, 2019, J CELL BIOCHEM, V120, P9532, DOI 10.1002/jcb.28229
   Loh YC, 2020, LIFE SCI, V249, DOI 10.1016/j.lfs.2020.117512
   Lorenzo-Almorós A, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-017-0506-x
   Ma L, 2018, MED SCI MONITOR, V24, P5368, DOI 10.12659/MSM.911455
   Maleki SJ, 2019, FOOD CHEM, V299, DOI 10.1016/j.foodchem.2019.125124
   Martens S, 2005, PHYTOCHEMISTRY, V66, P2399, DOI 10.1016/j.phytochem.2005.07.013
   Bueno JM, 2012, CRIT REV ANAL CHEM, V42, P126, DOI 10.1080/10408347.2011.632314
   Moens U, 2013, GENES-BASEL, V4, P101, DOI 10.3390/genes4020101
   Mollace V, 2019, ENDOCR METAB IMMUNE, V19, P136, DOI 10.2174/1871530319666181203151513
   Morris ME, 2006, LIFE SCI, V78, P2116, DOI 10.1016/j.lfs.2005.12.003
   Musolino V, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-59485-3
   Nagao T, 2007, OBESITY, V15, P1473, DOI 10.1038/oby.2007.176
   Nakamura M, 2018, NAT REV CARDIOL, V15, P387, DOI 10.1038/s41569-018-0007-y
   Ni R, 2016, FREE RADICAL BIO MED, V90, P12, DOI 10.1016/j.freeradbiomed.2015.11.013
   Oeckinghaus A, 2009, CSH PERSPECT BIOL, V1, DOI 10.1101/cshperspect.a000034
   Ogier JM, 2020, J MOL MED, V98, P335, DOI 10.1007/s00109-020-01878-y
   Volpe CMO, 2018, CELL DEATH DIS, V9, DOI 10.1038/s41419-017-0135-z
   Othman AI, 2017, BIOMED PHARMACOTHER, V94, P362, DOI 10.1016/j.biopha.2017.07.129
   Othman AI, 2017, EUR J PHARMACOL, V794, P27, DOI 10.1016/j.ejphar.2016.11.014
   Panche AN, 2016, J NUTR SCI, V5, DOI 10.1017/jns.2016.41
   Paolillo S, 2019, HEART FAIL CLIN, V15, P341, DOI 10.1016/j.hfc.2019.02.003
   Park JH, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-27788-1
   Paul J, 2021, JMIR RES PROTOC, V10, DOI 10.2196/25085
   Paul S, 2020, J DIABETES COMPLICAT, V34, DOI 10.1016/j.jdiacomp.2020.107613
   Pietta P, 2003, STUD NAT PROD CHEM, V28, P257
   Prabhu SD, 2016, CIRC RES, V119, P91, DOI 10.1161/CIRCRESAHA.116.303577
   Qiu ZP, 2020, J BIOL REG HOMEOS AG, V34, P2271, DOI 10.23812/20-111-L
   Rajesh M, 2010, J AM COLL CARDIOL, V56, P2115, DOI 10.1016/j.jacc.2010.07.033
   Ramírez E, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-172
   Rasbach KA, 2008, J PHARMACOL EXP THER, V325, P536, DOI 10.1124/jpet.107.134882
   Ribeiro CB, 2019, PHYTOTHER RES, V33, P1921, DOI 10.1002/ptr.6386
   Rieg T, 2018, DIABETOLOGIA, V61, P2079, DOI 10.1007/s00125-018-4654-7
   Ritchie RH, 2009, PHARMACOL THERAPEUT, V124, P279, DOI 10.1016/j.pharmthera.2009.08.001
   Roohbakhsh A, 2015, LIFE SCI, V124, P64, DOI 10.1016/j.lfs.2014.12.030
   Rose BA, 2010, PHYSIOL REV, V90, P1507, DOI 10.1152/physrev.00054.2009
   Roslan J, 2017, BIOMED PHARMACOTHER, V86, P570, DOI 10.1016/j.biopha.2016.12.044
   RUBLER S, 1972, AM J CARDIOL, V30, P595, DOI 10.1016/0002-9149(72)90595-4
   Russo I, 2016, J MOL CELL CARDIOL, V90, P84, DOI 10.1016/j.yjmcc.2015.12.011
   Macarro MS, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051475
   Seferovic PM, 2015, EUR HEART J, V36, P1718, DOI 10.1093/eurheartj/ehv134
   Shi GJ, 2019, BIOMED PHARMACOTHER, V109, P1085, DOI 10.1016/j.biopha.2018.10.130
   Shoji T, 2017, DIABETES RES CLIN PR, V129, P43, DOI 10.1016/j.diabres.2017.03.028
   Singh RM, 2017, HEART FAIL REV, V22, P843, DOI 10.1007/s10741-017-9634-3
   Su DM, 2021, J BIOCHEM MOL TOXIC, V35, DOI 10.1002/jbt.22629
   Su DM, 2016, BIOCHEM BIOPH RES CO, V479, P887, DOI 10.1016/j.bbrc.2016.09.101
   Suchal K, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18051001
   Sulaiman M, 2010, AM J PHYSIOL-HEART C, V298, pH833, DOI 10.1152/ajpheart.00418.2009
   Szkudelska K, 2007, J STEROID BIOCHEM, V105, P37, DOI 10.1016/j.jsbmb.2007.01.005
   Tan CX, 2017, AM J CHINESE MED, V45, P1169, DOI 10.1142/S0192415X17500641
   Taub PR, 2012, CTS-CLIN TRANSL SCI, V5, P43, DOI 10.1111/j.1752-8062.2011.00357.x
   Tourki B, 2017, FASEB J, V31, P4226, DOI 10.1096/fj.201700109R
   Travers JG, 2016, CIRC RES, V118, P1021, DOI 10.1161/CIRCRESAHA.115.306565
   Tu WJ, 2019, AGING DIS, V10, P637, DOI 10.14336/AD.2018.0513
   van Empel VPM, 2004, CARDIOVASC RES, V63, P487, DOI 10.1016/j.cardiores.2004.02.013
   Wang TY, 2018, ASIAN J PHARM SCI, V13, P12, DOI 10.1016/j.ajps.2017.08.004
   Wang Y, 2020, BIOSCI BIOTECH BIOCH, V84, P2533, DOI 10.1080/09168451.2020.1815170
   Wang YP, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17010019
   Xiao C, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/2719252
   Xiao JianBo Xiao JianBo, 2017, Critical Reviews in Food Science and Nutrition, V57, P1874
   Yang LP, 2017, NUTRIENTS, V9, DOI 10.3390/nu9101104
   Yang Z, 2014, MOL MED REP, V9, P1941, DOI 10.3892/mmr.2014.2002
   Yin MS, 2019, J ASIAN NAT PROD RES, V21, P476, DOI 10.1080/10286020.2017.1405941
   Yu HL, 2019, ARTIF CELL NANOMED B, V47, P3657, DOI 10.1080/21691401.2019.1657879
   Yusof NLM, 2017, INT J CARDIOL, V249, pS4, DOI 10.1016/j.ijcard.2017.09.037
   Yusof NLM, 2020, SAINS MALAYS, V49, P2499, DOI 10.17576/jsm-2020-4910-15
   Yusof NLM, 2018, APPL PHYSIOL NUTR ME, V43, P1224, DOI 10.1139/apnm-2018-0084
   Zhang B, 2017, SCI REP-UK, V7, DOI 10.1038/srep44239
   Zhang L, 2019, DRUG DEVELOP RES, V80, P294, DOI 10.1002/ddr.21495
   Zhang N, 2016, MOL CELL BIOCHEM, V417, P87, DOI 10.1007/s11010-016-2716-z
   Zhang SJ, 2018, BRAIN CIRC, V4, P174, DOI 10.4103/bc.bc_13_18
   Zhao CH, 2017, BIOCHEM BIOPH RES CO, V490, P552, DOI 10.1016/j.bbrc.2017.06.076
   Zhao PF, 2015, GENET MOL RES, V14, P17366, DOI 10.4238/2015.December.21.5
NR 140
TC 77
Z9 83
U1 0
U2 29
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAY
PY 2021
VL 22
IS 10
AR 5094
DI 10.3390/ijms22105094
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA SS8QA
UT WOS:000662015900001
PM 34065781
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Brookheart, RT
   Duncan, JG
AF Brookheart, Rita T.
   Duncan, Jennifer G.
TI Drosophila melanogaster: An emerging model of
   transgenerational effects of maternal obesity
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article
DE Obesity; Drosophila; Diabetes; Mitochondria; Pregnancy; Nutritional
   programming
ID HIGH-FAT-DIET; ENDOPLASMIC-RETICULUM STRESS; GESTATIONAL WEIGHT-GAIN;
   BODY-MASS INDEX; HUMAN SKELETAL-MUSCLE; INSULIN-RESISTANCE;
   MITOCHONDRIAL DYSFUNCTION; CARDIOMETABOLIC RISK; GLUCOSE-HOMEOSTASIS;
   NUTRITIONAL-STATUS
AB The prevalence of obesity in the world is endemic with one rapidly growing health concern being maternal obesity. Obesity during pregnancy increases the risk of gestational diabetes, miscarriage, and preeclampsia, while rendering offspring susceptible to developmental anomalies and long-term metabolic complications including type 2 diabetes and cardiovascular disease. Several studies in humans and rodents demonstrate a correlation between the risks of maternal overnutrition and factors such as epigenetics, mitochondrial dysfunction, insulin resistance, ER stress, and immune system disruption. At present, the molecular mechanisms connecting these factors to maternal obesity are unknown. This review focuses on the use of Drosophila melanogaster to study human metabolic diseases, including obesity, and its emerging use to elucidate the mechanisms of maternal overnutrition and the impact on offspring. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Brookheart, Rita T.; Duncan, Jennifer G.] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA.
C3 Washington University (WUSTL)
RP Duncan, JG (corresponding author), Washington Univ, Sch Med, 660 South Euclid Ave,Campus Box 8208, St Louis, MO 63110 USA.
EM duncan_j@wustl.edu
OI Brookheart, Rita/0000-0003-3247-3243
FU American Heart Association [IRG5450013, GRNT12080056, DRTC P30DK020579];
   National Institutes of Health [K12HD001459]
FX This work was supported by grants from the American Heart Association,
   IRG5450013 and GRNT12080056 (J.G.D), DRTC P30DK020579 (J.G.D) and the
   National Institutes of Health, K12HD001459 (R.T.B). The fly drawings in
   Figure 1 were generously provided by Leigh Zeidner.
CR Agrawal N, 2005, P NATL ACAD SCI USA, V102, P3777, DOI 10.1073/pnas.0500055102
   Aldrich JC, 2015, PLOS GENET, V11, DOI 10.1371/journal.pgen.1005148
   [Anonymous], 2015, OB OV
   Baker KD, 2007, CELL METAB, V6, P257, DOI 10.1016/j.cmet.2007.09.002
   BARKER DJP, 1990, BRIT MED J, V301, P1111, DOI 10.1136/bmj.301.6761.1111
   Bassett AR, 2013, CELL REP, V4, P220, DOI 10.1016/j.celrep.2013.06.020
   Binder NK, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0052304
   Birse RT, 2010, CELL METAB, V12, P533, DOI 10.1016/j.cmet.2010.09.014
   Borengasser SJ, 2014, PHYSIOL GENOMICS, V46, P841, DOI 10.1152/physiolgenomics.00059.2014
   Bruce KD, 2009, HEPATOLOGY, V50, P1796, DOI 10.1002/hep.23205
   Buescher JL, 2013, DIS MODEL MECH, V6, P1123, DOI 10.1242/dmm.011924
   Buss C, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0037758
   Catalano PM, 2009, AM J CLIN NUTR, V90, P1303, DOI 10.3945/ajcn.2008.27416
   Catalano PM, 2009, DIABETES CARE, V32, P1076, DOI 10.2337/dc08-2077
   Center V.D.R., 2015, VDRC TRANSG RNAI LIB
   Challier JC, 2008, PLACENTA, V29, P274, DOI 10.1016/j.placenta.2007.12.010
   Chen YP, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036329
   Cheng ZY, 2010, TRENDS ENDOCRIN MET, V21, P589, DOI 10.1016/j.tem.2010.06.005
   Cheng ZY, 2009, NAT MED, V15, P1307, DOI 10.1038/nm.2049
   Danielzik S, 2002, EUR J NUTR, V41, P132, DOI 10.1007/s00394-002-0367-1
   Davey Smith G, 2009, ADV EXP MED BIOL, V646, P1, DOI 10.1007/978-1-4020-9173-5_1
   Deshpande SA, 2014, NAT METHODS, V11, P535, DOI [10.1038/nmeth.2899, 10.1038/NMETH.2899]
   Diesel JC, 2015, PEDIATR OBES, V10, P305, DOI 10.1111/ijpo.262
   Dietzl G, 2007, NATURE, V448, P151, DOI 10.1038/nature05954
   Diop SB, 2015, CELL REP, V10, P1572, DOI 10.1016/j.celrep.2015.02.022
   Dobrosotskaya IY, 2002, SCIENCE, V296, P879, DOI 10.1126/science.1071124
   Dokras A, 2006, OBSTET GYNECOL, V108, P61, DOI 10.1097/01.AOG.0000219768.08249.b6
   Drummond-Barbosa D, 2001, DEV BIOL, V231, P265, DOI 10.1006/dbio.2000.0135
   Duncan J.G., 2014, DILP TRANSCRIP UNPUB
   Dunn GA, 2011, ENDOCRINOLOGY, V152, P2228, DOI 10.1210/en.2010-1461
   Dunn GA, 2009, ENDOCRINOLOGY, V150, P4999, DOI 10.1210/en.2009-0500
   Egger G, 2004, NATURE, V429, P457, DOI 10.1038/nature02625
   El-Helaly M, 2011, INT J OCCUP MED ENV, V24, P218, DOI 10.2478/s13382-011-0019-x
   Fariello RM, 2012, BJU INT, V110, P863, DOI 10.1111/j.1464-410X.2011.10813.x
   Fernandez-Moreno Miguel Angel, 2007, Methods Mol Biol, V372, P33, DOI 10.1007/978-1-59745-365-3_3
   Fernandez-Twinn DS, 2014, MOL METAB, V3, P325, DOI 10.1016/j.molmet.2014.01.007
   Forno E, 2014, PEDIATRICS, V134, pE535, DOI 10.1542/peds.2014-0439
   Frias AE, 2011, ENDOCRINOLOGY, V152, P2456, DOI 10.1210/en.2010-1332
   Garofalo RS, 2002, TRENDS ENDOCRIN MET, V13, P156, DOI 10.1016/S1043-2760(01)00548-3
   Gemma C, 2006, OBESITY, V14, P2193, DOI 10.1038/oby.2006.257
   Gemma C, 2009, OBESITY, V17, P1032, DOI 10.1038/oby.2008.605
   Gilbert WM, 1999, OBSTET GYNECOL, V93, P536, DOI 10.1016/S0029-7844(98)00484-0
   GODFREY KM, 1994, BRIT J OBSTET GYNAEC, V101, P398, DOI 10.1111/j.1471-0528.1994.tb11911.x
   Gonzalez-Bulnes A, 2014, J ENDOCRINOL, V223, pM17, DOI 10.1530/JOE-14-0217
   Goo CK, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0045806
   Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
   HALES CN, 1992, DIABETOLOGIA, V35, P595, DOI 10.1093/ije/dyt133
   Hales CN, 2001, BRIT MED BULL, V60, P5, DOI 10.1093/bmb/60.1.5
   Hartman TR, 2013, J CELL BIOL, V201, P741, DOI 10.1083/jcb.201212094
   Herbstman JB, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0072824
   Hochner H, 2012, CIRCULATION, V125, P1381, DOI 10.1161/CIRCULATIONAHA.111.070060
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   Hsu HJ, 2009, P NATL ACAD SCI USA, V106, P1117, DOI 10.1073/pnas.0809144106
   Hsu HJ, 2008, DEV BIOL, V313, P700, DOI 10.1016/j.ydbio.2007.11.006
   Igosheva N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010074
   Kang HL, 2002, P NATL ACAD SCI USA, V99, P838, DOI 10.1073/pnas.022631999
   Kelley DE, 2002, DIABETES, V51, P2944, DOI 10.2337/diabetes.51.10.2944
   Kobayashi T, 2011, GENES CELLS, V16, P617, DOI 10.1111/j.1365-2443.2011.01519.x
   Kong XX, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011707
   Kral JG, 2006, PEDIATRICS, V118, pE1644, DOI 10.1542/peds.2006-1379
   Kwan EX, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003329
   Laor A, 1997, BRIT MED J, V315, P449, DOI 10.1136/bmj.315.7106.449
   Leddy Meaghan A, 2008, Rev Obstet Gynecol, V1, P170
   Lee K.K., 2015, HYPERTENSION
   Leibowitz KL, 2012, WORLD J PEDIATR, V8, P76, DOI 10.1007/s12519-011-0292-6
   Liu ZH, 2013, ACTA BIOCH BIOPH SIN, V45, P44, DOI 10.1093/abbs/gms105
   Lowe A, 2011, J ALLERGY CLIN IMMUN, V128, P1107, DOI 10.1016/j.jaci.2011.08.025
   Luzzo KM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0049217
   Malti N, 2014, PLACENTA, V35, P411, DOI 10.1016/j.placenta.2014.03.010
   Gallardo JM, 2015, OBESITY, V23, P1650, DOI 10.1002/oby.21159
   Matzkin LM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059530
   Melo AM, 2014, METABOLISM, V63, P682, DOI 10.1016/j.metabol.2014.02.002
   Metwally M, 2008, FERTIL STERIL, V90, P714, DOI 10.1016/j.fertnstert.2007.07.1290
   Mingrone G, 2008, DIABETES CARE, V31, P1872, DOI 10.2337/dc08-0432
   Morino K, 2005, J CLIN INVEST, V115, P3587, DOI 10.1172/JCI25151
   Musselman LP, 2011, DIS MODEL MECH, V4, P842, DOI 10.1242/dmm.007948
   Myles IA, 2013, J IMMUNOL, V191, P3200, DOI 10.4049/jimmunol.1301057
   Na JB, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003175
   Neyen C, 2014, METHODS, V68, P116, DOI 10.1016/j.ymeth.2014.02.023
   Ng SF, 2014, FASEB J, V28, P1830, DOI 10.1096/fj.13-244046
   Nohr EA, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0008444
   O'Brien TE, 2003, EPIDEMIOLOGY, V14, P368, DOI 10.1097/00001648-200305000-00020
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Öst A, 2014, CELL, V159, P1352, DOI 10.1016/j.cell.2014.11.005
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Paredes S, 2009, P NATL ACAD SCI USA, V106, P17829, DOI 10.1073/pnas.0906811106
   Pasco MY, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036583
   Patel R, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0014607
   Petersen Kitt Falk, 2004, N Engl J Med, V350, P664
   Pospisilik JA, 2010, CELL, V140, P148, DOI 10.1016/j.cell.2009.12.027
   Prasad NG, 2003, EVOL ECOL RES, V5, P903
   Rajan A, 2013, BMC BIOL, V11, DOI 10.1186/1741-7007-11-38
   Rajan A, 2012, CELL, V151, P123, DOI 10.1016/j.cell.2012.08.019
   Reynolds RM, 2010, J CLIN ENDOCR METAB, V95, P5365, DOI 10.1210/jc.2010-0697
   Rulifson EJ, 2002, SCIENCE, V296, P1118, DOI 10.1126/science.1070058
   Saltiel AR, 2001, NATURE, V414, P799, DOI 10.1038/414799a
   Samuelsson AM, 2008, HYPERTENSION, V51, P383, DOI 10.1161/HYPERTENSIONAHA.107.101477
   Sánchez-Martínez A, 2006, BBA-BIOENERGETICS, V1757, P1190, DOI 10.1016/j.bbabio.2006.05.008
   Schmatz M, 2010, J PERINATOL, V30, P441, DOI 10.1038/jp.2009.182
   Seegmiller AC, 2002, DEV CELL, V2, P229, DOI 10.1016/S1534-5807(01)00119-8
   Sharp GC, 2015, INT J EPIDEMIOL, V44, P1288, DOI 10.1093/ije/dyv042
   Sleigh A, 2011, J CLIN INVEST, V121, P2457, DOI 10.1172/JCI46405
   Smith J, 2009, J CLIN ENDOCR METAB, V94, P4275, DOI 10.1210/jc.2009-0709
   Soubry A, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-29
   Srinivasan M, 2006, AM J PHYSIOL-ENDOC M, V290, pE129, DOI 10.1152/ajpendo.00248.2005
   Stothard KJ, 2009, JAMA-J AM MED ASSOC, V301, P636, DOI 10.1001/jama.2009.113
   Stump CS, 2003, P NATL ACAD SCI USA, V100, P7996, DOI 10.1073/pnas.1332551100
   Tan HC, 2015, PEDIATR DIABETES, V16, P419, DOI 10.1111/pedi.12273
   Taylor PD, 2005, AM J PHYSIOL-REG I, V288, pR134, DOI 10.1152/ajpregu.00355.2004
   Vahratian A, 2009, MATERN CHILD HLTH J, V13, P268, DOI 10.1007/s10995-008-0340-6
   Valtonen TM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031611
   Veenendaal MVE, 2013, BJOG-INT J OBSTET GY, V120, P548, DOI 10.1111/1471-0528.12136
   Vijendravarma RK, 2010, BIOL LETTERS, V6, P238, DOI 10.1098/rsbl.2009.0754
   Vucetic Z, 2010, ENDOCRINOLOGY, V151, P4756, DOI 10.1210/en.2010-0505
   Wilson RM, 2015, PEDIAT ALLERG IMM-UK, V26, P344, DOI 10.1111/pai.12387
   Wu LL, 2015, DEVELOPMENT, V142, P681, DOI 10.1242/dev.114850
   Wu LLY, 2010, ENDOCRINOLOGY, V151, P5438, DOI 10.1210/en.2010-0551
   Yogev Y, 2009, OBSTET GYN CLIN N AM, V36, P285, DOI 10.1016/j.ogc.2009.03.003
NR 118
TC 21
Z9 23
U1 0
U2 116
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
EI 1872-8057
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD NOV 5
PY 2016
VL 435
IS C
SI SI
BP 20
EP 28
DI 10.1016/j.mce.2015.12.003
PG 9
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA DW8YI
UT WOS:000383941000004
PM 26687062
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Cunha, FM
   da Silva, CCC
   Cerqueira, FM
   Kowaltowski, AJ
AF Cunha, Fernanda M.
   Caldeira da Silva, Camille C.
   Cerqueira, Fernanda M.
   Kowaltowski, Alicia J.
TI Mild Mitochondrial Uncoupling as a Therapeutic Strategy
SO CURRENT DRUG TARGETS
LA English
DT Review
DE Mitochondria; uncoupler; dinitrophenol; uncoupling protein; adenine
   nucleotide translocator; ATP-sensitive K+ channels
ID SENSITIVE K+-CHANNELS; SPARE RESPIRATORY CAPACITY; REACTIVE OXYGEN
   RELEASE; LIFE-SPAN; POTASSIUM CHANNEL; OXIDATIVE STRESS; CELL-DEATH;
   CALORIC RESTRICTION; OXIDANT STRESS; PROTON LEAK
AB Mild mitochondrial uncoupling, or the reduction of the efficiency of energy conversion without compromising intracellular high energy phosphate levels, is a protective therapeutic strategy under many laboratory conditions. Here we discuss these conditions, which include both cell and animal models of ischemia reperfusion and complications associated with the metabolic syndrome. We also discuss drugs that promote mild mitochondrial uncoupling and naturally occurring mild mitochondrial uncoupling pathways involving free fatty acid cycling and K+ transport.
C1 [Cunha, Fernanda M.; Caldeira da Silva, Camille C.; Cerqueira, Fernanda M.; Kowaltowski, Alicia J.] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-01498 Sao Paulo, Brazil.
C3 Universidade de Sao Paulo
RP Kowaltowski, AJ (corresponding author), Av Prof Lineu Prestes 748, BR-05508900 Sao Paulo, Brazil.
EM alicia@iq.usp.br
RI Kowaltowski, Alicia/H-8698-2012; cerqueira, fernanda/C-8326-2014;
   Marques da Cunha, Fernanda/G-3575-2012
OI Marques da Cunha, Fernanda/0000-0002-1583-5380
FU Fundacao de Amparo a Pesquisa no Estado de Sao Paulo (FAPESP); Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq); John Simon
   Guggenheim Memorial Foundation; Instituto Nacional de Ciencia e
   Tecnologia de Processos Redox em Biomedicina (Redoxoma)
FX This work is supported by Fundacao de Amparo a Pesquisa no Estado de Sao
   Paulo (FAPESP), Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq), The John Simon Guggenheim Memorial Foundation and
   the Instituto Nacional de Ciencia e Tecnologia de Processos Redox em
   Biomedicina (Redoxoma). The authors thank Professor Vitor Ferreira for
   helpful discussions.
CR Abramov AY, 2007, J NEUROSCI, V27, P1129, DOI 10.1523/JNEUROSCI.4468-06.2007
   Abramov AY, 2010, BBA-GEN SUBJECTS, V1800, P297, DOI 10.1016/j.bbagen.2009.08.002
   Alberici LC, 2006, GASTROENTEROLOGY, V131, P1228, DOI 10.1053/j.gastro.2006.07.021
   Alberici LC, 2009, FREE RADICAL BIO MED, V47, P1432, DOI 10.1016/j.freeradbiomed.2009.08.013
   Andrews ZB, 2010, ENDOCRINOLOGY, V151, P2078, DOI 10.1210/en.2009-0850
   Andrews ZB, 2009, AM J PHYSIOL-ENDOC M, V296, pE621, DOI 10.1152/ajpendo.90903.2008
   Bajgar R, 2001, J BIOL CHEM, V276, P33369, DOI 10.1074/jbc.M103320200
   Barros MH, 2004, J BIOL CHEM, V279, P49883, DOI 10.1074/jbc.M408918200
   Bernardi P, 2002, VITAM HORM, V65, P97, DOI 10.1016/S0083-6729(02)65061-7
   Brennan JP, 2006, CARDIOVASC RES, V72, P313, DOI 10.1016/j.cardiores.2006.07.019
   BRUSTOVETSKY N, 1994, J BIOL CHEM, V269, P27329
   Cancherini DV, 2003, AM J PHYSIOL-RENAL, V285, pF1291, DOI 10.1152/ajprenal.00103.2003
   Carreira RS, 2007, J BIOENERG BIOMEMBR, V39, P313, DOI 10.1007/s10863-007-9093-y
   Choi K, 2009, CURR NEUROVASC RES, V6, P213, DOI 10.2174/156720209789630375
   Colman E, 2007, REGUL TOXICOL PHARM, V48, P115, DOI 10.1016/j.yrtph.2007.03.006
   Costa ADT, 2006, AM J PHYSIOL-HEART C, V290, pH406, DOI 10.1152/ajpheart.00794.2005
   da Silva CCC, 2008, AGING CELL, V7, P552, DOI 10.1111/j.1474-9726.2008.00407.x
   De Felice FG, 2006, IUBMB LIFE, V58, P185, DOI 10.1080/15216540600702198
   De Souza CT, 2007, FASEB J, V21, P1153, DOI 10.1096/fj.06-7148com
   Domoki F, 1999, STROKE, V30, P2713, DOI 10.1161/01.STR.30.12.2713
   Dong L, 2009, CLIN EXP PHARMACOL P, V36, pe57, DOI 10.1111/j.1440-1681.2009.05222.x
   Echtay KS, 2000, NATURE, V408, P609, DOI 10.1038/35046114
   Echtay KS, 2002, NATURE, V415, P96, DOI 10.1038/415096a
   Echtay KS, 2002, J BIOL CHEM, V277, P47129, DOI 10.1074/jbc.M208262200
   Facundo HTF, 2007, FREE RADICAL BIO MED, V42, P1039, DOI 10.1016/j.freeradbiomed.2007.01.001
   Facundo HTF, 2006, FREE RADICAL BIO MED, V40, P469, DOI 10.1016/j.freeradbiomed.2005.08.041
   Facundo HTF, 2006, BBA-MOL BASIS DIS, V1762, P202, DOI 10.1016/j.bbadis.2005.06.003
   Facundo HTF, 2005, J BIOENERG BIOMEMBR, V37, P75, DOI 10.1007/s10863-005-4130-1
   Fornazari M, 2008, J NEUROSCI RES, V86, P1548, DOI 10.1002/jnr.21614
   Garlid KD, 2003, BBA-BIOENERGETICS, V1606, P23, DOI 10.1016/S0005-2728(03)00108-7
   Garlid KD, 1997, CIRC RES, V81, P1072
   Harrison R, 2004, DRUG METAB REV, V36, P363, DOI 10.1081/DMR-120037569
   Holmuhamedov EL, 2004, FEBS LETT, V568, P167, DOI 10.1016/j.febslet.2004.05.031
   Hsiao AL, 2005, CLIN TOXICOL, V43, P281, DOI 10.1081/CLT-200058946
   Hwang ES, 2007, CRIT REV FOOD SCI, V47, P27, DOI 10.1080/10408390600550299
   Johnson-Cadwell LI, 2007, J NEUROCHEM, V101, P1619, DOI 10.1111/j.1471-4159.2007.04516.x
   Korde AS, 2005, J NEUROTRAUM, V22, P1142, DOI 10.1089/neu.2005.22.1142
   Korde AS, 2005, J NEUROCHEM, V94, P1676, DOI 10.1111/j.1471-4159.2005.03328.x
   Korshunov SS, 1997, FEBS LETT, V416, P15, DOI 10.1016/S0014-5793(97)01159-9
   Kowaltowski AJ, 2001, AM J PHYSIOL-HEART C, V280, pH649, DOI 10.1152/ajpheart.2001.280.2.H649
   Kowaltowski AJ, 2009, FREE RADICAL BIO MED, V47, P333, DOI 10.1016/j.freeradbiomed.2009.05.004
   Lambert AJ, 2004, AM J PHYSIOL-REG I, V286, pR71, DOI 10.1152/ajpregu.00341.2003
   LEDVINA M, 1980, EXP GERONTOL, V15, P67, DOI 10.1016/0531-5565(80)90076-5
   Liu D, 2008, ANN NY ACAD SCI, V1147, P275, DOI 10.1196/annals.1427.028
   Liu WH, 2009, J CELL MOL MED, V13, P1695, DOI 10.1111/j.1582-4934.2008.00473.x
   López-Lluch G, 2006, P NATL ACAD SCI USA, V103, P1768, DOI 10.1073/pnas.0510452103
   LOSCHEN G, 1971, FEBS LETT, V18, P261, DOI 10.1016/0014-5793(71)80459-3
   Lou PH, 2007, BIOCHEM J, V407, P129, DOI 10.1042/BJ20070606
   Maczewski M, 2004, J PHYSIOL PHARMACOL, V55, P537
   Mattiasson G, 2003, NAT MED, V9, P1062, DOI 10.1038/nm903
   McFee RB, 2004, VET HUM TOXICOL, V46, P251
   Minners J, 2000, CARDIOVASC RES, V47, P68, DOI 10.1016/S0008-6363(00)00069-9
   Miranda EJ, 2006, J ANAL TOXICOL, V30, P219, DOI 10.1093/jat/30.3.219
   Modriansky M, 2009, J BIOENERG BIOMEMBR, V41, P133, DOI 10.1007/s10863-009-9212-z
   Moller P, 2006, FREE RADICAL BIO MED, V41, P388, DOI 10.1016/j.freeradbiomed.2006.04.001
   MURRY CE, 1986, CIRCULATION, V74, P1124, DOI 10.1161/01.CIR.74.5.1124
   Nadtochiy SM, 2006, BIOCHEM J, V395, P611, DOI 10.1042/BJ20051927
   Navet R, 2005, FEBS LETT, V579, P4437, DOI 10.1016/j.febslet.2005.07.008
   Nicholls DG, 2009, BIOCHEM SOC T, V37, P1385, DOI 10.1042/BST0371385
   Nisoli E, 2005, SCIENCE, V310, P314, DOI 10.1126/science.1117728
   Padalko VI, 2005, BIOCHEMISTRY-MOSCOW+, V70, P986, DOI 10.1007/s10541-005-0213-1
   Pain T, 2000, CIRC RES, V87, P460
   PARASCANDOLA J, 1974, MOL CELL BIOCHEM, V5, P69, DOI 10.1007/BF01874175
   Paula-Lima AC, 2008, BIOL RES, V41, P129, DOI /S0716-97602008000200001
   Robin E, 2007, J BIOL CHEM, V282, P19133, DOI 10.1074/jbc.M701917200
   Rodrigo GC, 2002, J MOL CELL CARDIOL, V34, P555, DOI 10.1006/jmcc.2002.1536
   Sanz A, 2006, ANTIOXID REDOX SIGN, V8, P582, DOI 10.1089/ars.2006.8.582
   Shao H, 2008, BRIT J PHARMACOL, V153, P1641, DOI 10.1038/bjp.2008.45
   Skulachev VP, 1998, BBA-BIOENERGETICS, V1363, P100, DOI 10.1016/S0005-2728(97)00091-1
   Skulachev VP, 1999, J BIOENERG BIOMEMBR, V31, P431, DOI 10.1023/A:1005492205984
   Sluse FE, 2006, BBA-BIOENERGETICS, V1757, P480, DOI 10.1016/j.bbabio.2006.02.004
   SOHAL RS, 1994, MECH AGEING DEV, V74, P121, DOI 10.1016/0047-6374(94)90104-X
   Sun ZL, 2008, AM J PHYSIOL-RENAL, V294, pF491, DOI 10.1152/ajprenal.00263.2007
   Szewczyk A, 2009, IUBMB LIFE, V61, P134, DOI 10.1002/iub.155
   Tahara EB, 2007, FASEB J, V21, P274, DOI 10.1096/fj.06-6686com
   Tainter ML, 1938, J PHARMACOL EXP THER, V63, P51
   TAPPEL A, 1973, J GERONTOL, V28, P415, DOI 10.1093/geronj/28.4.415
   Tewari A, 2009, BRIT J ANAESTH, V102, P566, DOI 10.1093/bja/aep033
   Tretter L, 2007, J NEUROCHEM, V103, P1864, DOI 10.1111/j.1471-4159.2007.04891.x
   Turrens JF, 2003, J PHYSIOL-LONDON, V552, P335, DOI 10.1113/jphysiol.2003.049478
   Vanden Hoek TL, 2000, CIRC RES, V86, P541, DOI 10.1161/01.RES.86.5.541
   VandenHoek TL, 1997, J MOL CELL CARDIOL, V29, P2571, DOI 10.1006/jmcc.1997.0497
   Vercesi AE, 2007, IUBMB LIFE, V59, P263, DOI 10.1080/15216540601178091
   Walder CE, 1997, STROKE, V28, P2252, DOI 10.1161/01.STR.28.11.2252
   Wasilewska-Sampaio AP, 2005, FASEB J, V19, P1627, DOI 10.1096/fj.05-3812com
   Weid W, 2005, J BIOMED SCI, V12, P521, DOI 10.1007/s11373-005-3730-4
   WOITCZAK L, 1993, BIOCHIM BIOPHYS ACTA, V1183, P41, DOI 10.1016/0005-2728(93)90004-Y
   Wojtczak L, 1999, J BIOENERG BIOMEMBR, V31, P447, DOI 10.1023/A:1005444322823
   Yellon DM, 2003, PHYSIOL REV, V83, P1113, DOI 10.1152/physrev.00009.2003
   Zhang CY, 2006, CELL METAB, V3, P417, DOI 10.1016/j.cmet.2006.04.010
   Zhang DX, 2001, CIRC RES, V89, P1177, DOI 10.1161/hh2401.101752
NR 91
TC 72
Z9 75
U1 1
U2 34
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-4501
EI 1873-5592
J9 CURR DRUG TARGETS
JI Curr. Drug Targets
PD JUN
PY 2011
VL 12
IS 6
BP 783
EP 789
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 777QW
UT WOS:000291640000004
PM 21275885
DA 2025-06-11
ER

PT J
AU Artero, EG
   Ferrez-Marquez, M
   Torrente-Sanchez, MJ
   Martínez-Rosales, E
   Carretero-Ruiz, A
   Hernandez-Martínez, A
   López-Sanchez, L
   Esteban-Simón, A
   del Rey, AR
   Alcaraz-Ibañez, M
   Rodríguez-Pérez, MA
   Villa-Gonzalez, E
   Barranco-Ruiz, Y
   Martínez-Forte, S
   Castillo, C
   Navarro, CG
   Cubero, JA
   Parrilla, RR
   Gómez, JAA
   Femia, P
   Fernandez-Alonso, AM
   Soriano-Maldonado, A
AF Artero, Enrique G.
   Ferrez-Marquez, Manuel
   Torrente-Sanchez, Maria Jose
   Martinez-Rosales, Elena
   Carretero-Ruiz, Alejandro
   Hernandez-Martinez, Alba
   Lopez-Sanchez, Laura
   Esteban-Simon, Alba
   Romero del Rey, Andrea
   Alcaraz-Ibanez, Manuel
   Rodriguez-Perez, Manuel A.
   Villa-Gonzalez, Emilio
   Barranco-Ruiz, Yaira
   Martinez-Forte, Sonia
   Castillo, Carlos
   Gomez Navarro, Carlos
   Aceituno Cubero, Jesus
   Reyes Parrilla, Raul
   Aparicio Gomez, Jose A.
   Femia, Pedro
   Fernandez-Alonso, Ana M.
   Soriano-Maldonado, Alberto
TI Supervised Exercise Immediately After Bariatric Surgery: the Study
   Protocol of the EFIBAR Randomized Controlled Trial
SO OBESITY SURGERY
LA English
DT Article
DE Obesity; Bariatric surgery; Exercise; Randomized controlled trial (RCT);
   Protocol
ID WEIGHT-LOSS; SPANISH VERSION; PHYSICAL-ACTIVITY; GASTRIC BYPASS;
   MENTAL-HEALTH; VALIDATION; RATIONALE; FITNESS; DESIGN; ADULTS
AB Background Previous studies have investigated weight loss caused by exercise following bariatric surgery. However, in most cases, the training program is poorly reported; the exercise type, volume, and intensity are briefly mentioned; and the sample size, selection criteria, and follow-up time vary greatly across studies.
   Purpose The EFIBAR study aims to investigate over 1 year the effects of a 16-week supervised exercise program, initiated immediately after bariatric surgery, on weight loss (primary outcome), body composition, cardiometabolic risk, physical fitness, and quality of life in patients with severe/extreme obesity.
   Material and Methods The EFIBAR study is a parallel-group, superiority, randomized controlled trial (RCT), comprising 80 surgery patients. Half of the participants, randomly selected, perform a 16-week supervised exercise program, including both strength and aerobic training, starting immediately after the surgery (7-14 days). For each participant, all primary and secondary outcomes are measured at three different time points: (i) before the surgery, (ii) after the intervention (approximate to 4 months), and (iii) 1 year after the surgery.
   Conclusion The EFIBAR study will provide new insights into the multidimensional benefits of exercise in adults with severe/extreme obesity following bariatric surgery.
C1 [Artero, Enrique G.; Martinez-Rosales, Elena; Carretero-Ruiz, Alejandro; Hernandez-Martinez, Alba; Lopez-Sanchez, Laura; Esteban-Simon, Alba; Rodriguez-Perez, Manuel A.; Soriano-Maldonado, Alberto] Univ Almeria, Dept Educ, Fac Educ Sci, SPORT Res Grp CTS 1024,CERNEP Res Ctr, Almeria, Spain.
   [Ferrez-Marquez, Manuel] Torrecardenas Univ Hosp, Gen & Bariatr Surg Unit, Almeria, Spain.
   [Ferrez-Marquez, Manuel; Torrente-Sanchez, Maria Jose] Hosp Mediterraneo, Almeria, Spain.
   [Romero del Rey, Andrea] Torrecardenas Univ Hosp, Pediat Unit, Almeria, Spain.
   [Alcaraz-Ibanez, Manuel] Univ Almeria, Dept Educ, Almeria, Spain.
   [Alcaraz-Ibanez, Manuel] Univ Almeria, Hlth Res Ctr, Almeria, Spain.
   [Villa-Gonzalez, Emilio; Barranco-Ruiz, Yaira] Univ Granada, PROFITH Promoting Fitness & Hlth Phys Act Res Grp, Dept Phys & Sports Educ, Fac Educ & Sport Sci,Sport & Hlth Univ Res Inst i, Melilla, Spain.
   [Martinez-Forte, Sonia; Fernandez-Alonso, Ana M.] Torrecardenas Univ Hosp, Obstet & Gynecol Unit, Almeria, Spain.
   [Castillo, Carlos] Univ Almeria, Dept Econ & Business, SPORT Res Grp CTS 1024, CERNEP Res Ctr, Almeria, Spain.
   [Gomez Navarro, Carlos; Aceituno Cubero, Jesus; Reyes Parrilla, Raul; Aparicio Gomez, Jose A.] Torrecardenas Univ Hosp, Unit Cardiol, Almeria, Spain.
   [Femia, Pedro] Univ Granada, Dept Stat & Operat Res, Fac Med, Granada, Spain.
C3 Universidad de Almeria; Universidad de Almeria; Universidad de Almeria;
   University of Granada; Universidad de Almeria; University of Granada
RP Artero, EG (corresponding author), Univ Almeria, Dept Educ, Fac Educ Sci, SPORT Res Grp CTS 1024,CERNEP Res Ctr, Almeria, Spain.
EM artero@ual.es
RI Femia, Pedro/C-1367-2011; Rodríguez-Pérez, Manuel/AAU-6670-2021;
   Martínez-Rosales, Elena/AAC-5236-2019; Castillo, Carlos/JJE-5679-2023;
   López-Sánchez, Laura/GNP-1938-2022; Alonso, Ana/Z-6241-2019;
   Esteban-Simón, Alba/AAS-5739-2021; Hernández-Martínez,
   Alba/AAC-7274-2019; Villa-González, Emilio/G-6421-2015; Barranco-Ruiz,
   Yaira/G-3007-2017; Artero, Enrique G./L-8628-2014; Soriano-Maldonado,
   Alberto/I-6379-2015; Alcaraz-Ibanez, Manuel/Z-2574-2019
OI Martinez-Rosales, Elena/0000-0002-8106-6823; Esteban-Simon,
   Alba/0000-0001-5296-4379; Artero, Enrique G./0000-0002-2618-6128;
   Soriano-Maldonado, Alberto/0000-0002-4626-420X; Femia,
   Pedro/0000-0002-1746-5619; Alcaraz-Ibanez, Manuel/0000-0002-1297-9565;
   Fernandez Alonso, Ana Maria/0000-0002-4844-2145; Lopez-Sanchez,
   Laura/0000-0001-5903-8327
FU Spanish Ministry of Economy and Competitiveness (MINECO), Plan Nacional
   de I+D+i calls RETOS [DEP2016-74926-R, RTI2018-093302-A-I00]; Spanish
   Ministry of Science, Innovation and Universities [FPU18/01107,
   FPU17/01158]; predoctoral fellowship program of the University of
   Almeria
FX This work was supported by the Spanish Ministry of Economy and
   Competitiveness (MINECO), Plan Nacional de I+D+i calls RETOS 2016
   (reference DEP2016-74926-R) and RETOS 2018 (reference
   RTI2018-093302-A-I00). EM-R and MAI were funded by the Spanish Ministry
   of Science, Innovation and Universities (FPU18/01107 and FPU17/01158,
   respectively). AH-M and LL-S were funded by the predoctoral fellowship
   program of the University of Almeria. The funding sources approved this
   study although they had no role in the design and will not have any role
   during its execution, analyses and interpretation of the data, writing
   manuscripts, or decision to submit for publication.
CR ALONSO J, 1995, MED CLIN-BARCELONA, V104, P771
   Anekwe CV, 2020, CURR OBES REP, V9, P272, DOI 10.1007/s13679-020-00398-7
   Martínez-González MA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043134
   Armitage P., 2005, ENCY BIOSTATISTICS
   Badia X, 1999, MED CLIN-BARCELONA, V112, P79
   Bados A, 2005, PSICOTHEMA, V17, P679
   Bellicha A, 2018, OBES REV, V19, P1544, DOI 10.1111/obr.12740
   BRUCE R A, 1963, Pediatrics, V32, P742
   Buchwald H., 2004, JAMA (Journal of the American Medical Association), V292, P1724, DOI 10.1001/jama.292.14.1724
   Cadenas-Sánchez C, 2016, CONTEMP CLIN TRIALS, V47, P315, DOI 10.1016/j.cct.2016.02.007
   Carbonell-Baeza A, 2011, BRIT J SPORT MED, V45, P1189, DOI 10.1136/bjsm.2009.070896
   Carretero-Ruiz A, 2019, OBES SURG, V29, P3371, DOI 10.1007/s11695-019-04096-9
   Chan AW, 2013, ANN INTERN MED, V158, P200, DOI 10.7326/0003-4819-158-3-201302050-00583
   Coen PM, 2018, EXERC SPORT SCI REV, V46, P262, DOI 10.1249/JES.0000000000000168
   Coen PM, 2015, DIABETES, V64, P3737, DOI 10.2337/db15-0809
   Coen PM, 2015, J CLIN INVEST, V125, P248, DOI 10.1172/JCI78016
   Coll-Risco I, 2019, J CLIN MED, V8, DOI 10.3390/jcm8101678
   Di Cesare M, 2016, LANCET, V387, P1377, DOI 10.1016/s0140-6736(16)30054-x
   Donaldson SC, 2016, MED SCI SPORT EXER, V48, P755, DOI 10.1249/MSS.0000000000000828
   Echeverria G, 2017, PSICOTHEMA, V29, P96, DOI 10.7334/psicothema2016.3
   Egberts K, 2012, OBES SURG, V22, P335, DOI 10.1007/s11695-011-0544-5
   Escobar A, 2002, CLIN RHEUMATOL, V21, P466, DOI 10.1007/s100670200117
   Fernández-Ballarth JD, 2010, BRIT J NUTR, V103, P1808, DOI 10.1017/S0007114509993837
   Freitas PD, 2018, MED SCI SPORT EXER, V50, P1367, DOI 10.1249/MSS.0000000000001574
   Guazzi M, 2012, EUR HEART J, V33, P2917, DOI 10.1093/eurheartj/ehs221
   Ibacache P, 2020, OBES SURG, V30, P4038, DOI 10.1007/s11695-020-04721-y
   Basterra-Gortari FJ, 2011, REV ESP CARDIOL, V64, P424, DOI [10.1016/j.recesp.2010.06.010, 10.1016/j.rec.2010.06.015]
   Labayen I, 2020, DIABETES CARE, V43, P306, DOI 10.2337/dc19-0351
   Lakka TA, 2005, HANDB EXP PHARM, V170, P137
   Livhits M, 2010, OBES SURG, V20, P657, DOI 10.1007/s11695-010-0096-0
   Martínez-Rosales E, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17249501
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McConnell S, 2001, ARTHRIT RHEUM-ARTHR, V45, P453, DOI 10.1002/1529-0131(200110)45:5<453::AID-ART365>3.0.CO;2-W
   Mechanick JI, 2013, SURG OBES RELAT DIS, V9, P159, DOI 10.1016/j.soard.2012.12.010
   Norton K., 2019, Kinanthropometry and exercise physiology, V4th ed.
   Nuijten MAH, 2020, OBES SURG, V30, P3119, DOI 10.1007/s11695-020-04654-6
   Papaioannou TG, 2013, INT J CARDIOL, V169, P57, DOI 10.1016/j.ijcard.2013.08.079
   Ricci C, 2015, OBES SURG, V25, P397, DOI 10.1007/s11695-014-1442-4
   Rikli RE, 1999, J AGING PHYS ACTIV, V7, P129, DOI 10.1123/japa.7.2.129
   Ruiz-Ruiz J, 2002, J HAND SURG-AM, V27A, P897, DOI 10.1053/jhsu.2002.34315
   Sanchez-Delgado G, 2015, CONTEMP CLIN TRIALS, V45, P416, DOI 10.1016/j.cct.2015.11.004
   Sasaki JE, 2011, J SCI MED SPORT, V14, P411, DOI 10.1016/j.jsams.2011.04.003
   Schröder H, 2011, J NUTR, V141, P1140, DOI 10.3945/jn.110.135566
   Schulz KF, 2002, LANCET, V359, P515, DOI 10.1016/S0140-6736(02)07683-3
   Sczepaniak JP, 2015, OBES SURG, V25, P788, DOI 10.1007/s11695-014-1496-3
   Slade SC, 2016, BRIT J SPORT MED, V50, P1428, DOI 10.1136/bjsports-2016-096651
   Soriano-Maldonado A, 2018, J CLIN MED, V7, DOI 10.3390/jcm7120477
   Soriano-Maldonado A, 2018, ATHEROSCLEROSIS, V278, P330, DOI 10.1016/j.atherosclerosis.2018.08.026
   Swift DL, 2014, PROG CARDIOVASC DIS, V56, P441, DOI 10.1016/j.pcad.2013.09.012
   van de Laar A, 2012, OBES SURG, V22, P1843, DOI 10.1007/s11695-012-0736-7
   Villa-González E, 2019, BMC SURG, V19, DOI 10.1186/s12893-019-0566-9
   Weiss W, 2012, BLOOD PRESS MONIT, V17, P128, DOI 10.1097/MBP.0b013e328353ff63
   Wolfe BM, 2016, CIRC RES, V118, P1844, DOI 10.1161/CIRCRESAHA.116.307591
NR 53
TC 4
Z9 4
U1 4
U2 12
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0960-8923
EI 1708-0428
J9 OBES SURG
JI Obes. Surg.
PD OCT
PY 2021
VL 31
IS 10
BP 4227
EP 4235
DI 10.1007/s11695-021-05559-8
EA JUL 2021
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA UW2OF
UT WOS:000673891200002
PM 34268680
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Roos, C
   Lidfeldt, J
   Agardh, CD
   Nyberg, P
   Nerbrand, C
   Samsioe, G
   Westrin, A
AF Roos, Camilla
   Lidfeldt, Jonas
   Agardh, Carl-David
   Nyberg, Per
   Nerbrand, Christina
   Samsioe, Goran
   Westrin, Asa
TI Insulin resistance and self-rated symptoms of depression in Swedish
   women with risk factors for diabetes: the Women's Health in the Lund
   Area study
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID EXERCISE TREATMENT; HEART; BDNF
AB Previous studies have suggested that depression increases the risk for diabetes and that this may be mediated through insulin resistance. The study aimed to analyze if self-rated symptoms of depression are related to insulin resistance among middle-aged and older Swedish women with features of the metabolic syndrome and being at risk for type 2 diabetes mellitus. We analyzed data from 1047 Swedish women aged 50 to 64 years without a history of diabetes and living in the southern part of Sweden. A variable se f-ratedsyniptoms of depression (SRSD) was defined by using the Gothenburg Quality of Life instrument. We estimated odds ratios (ORs) to detennine whether or not SRSD was associated with the homeostasis model assessment of insulin resistance. The variable SRSD was not associated with insulin resistance. However, it was positively associated with waist-hip ratio (OR, 1.95; 95% confidence interval, 1.28-3.00) and negatively associated with physical exercise (OR, 1.29 - 95% confidence interval, 0.99-1.68) after multivariate adjustment. In conclusion, lifestyle factors such as physical inactivity and abdominal obesity, but not insulin resistance, seem to be related to ' self-rated symptoms of depression in women with risk factors for diabetes mellitus. The relationship between insulin resistance and major depression needs to be further examined. (c) 2007 Elsevier Inc. All rights reserved.
C1 Univ Lund Hosp, Dept Clin Sci, Div Psychiat, SE-22185 Lund, Sweden.
   Lund Univ, Malmo Univ Hosp, Dept Clin Sci, SE-20502 Malmo, Sweden.
   Lund Univ, Div Nursing, Dept Hlth Sci, SE-22100 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital; Lund University
RP Westrin, A (corresponding author), Univ Lund Hosp, Dept Clin Sci, Div Psychiat, SE-22185 Lund, Sweden.
EM asa.westrin@med.lu.se
CR Agardh EE, 2003, DIABETES CARE, V26, P719, DOI 10.2337/diacare.26.3.719
   Angelucci F, 2005, MOL PSYCHIATR, V10, P345, DOI 10.1038/sj.mp.4001637
   Babyak M, 2000, PSYCHOSOM MED, V62, P633, DOI 10.1097/00006842-200009000-00006
   Berchtold NC, 2005, NEUROSCIENCE, V133, P853, DOI 10.1016/j.neuroscience.2005.03.026
   Chiba M, 2000, METABOLISM, V49, P1145, DOI 10.1053/meta.2000.8611
   Dunn AL, 2005, AM J PREV MED, V28, P1, DOI 10.1016/j.amepre.2004.09.003
   Golomb BA, 2002, J CLIN EPIDEMIOL, V55, P767, DOI 10.1016/S0895-4356(02)00407-9
   Huang AM, 2006, J NEURAL TRANSM, V113, P803, DOI 10.1007/s00702-005-0359-4
   Karege F, 2002, PSYCHIAT RES, V109, P143, DOI 10.1016/S0165-1781(02)00005-7
   LAPIDUS L, 1989, APPETITE, V13, P25, DOI 10.1016/0195-6663(89)90024-X
   Lawlor DA, 2003, BRIT MED J, V327, P1383, DOI 10.1136/bmj.327.7428.1383
   Lidfeldt J, 2001, EUR J EPIDEMIOL, V17, P943, DOI 10.1023/A:1016291426124
   Mann JJ, 2005, JAMA-J AM MED ASSOC, V294, P2064, DOI 10.1001/jama.294.16.2064
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mattson MP, 2004, AGEING RES REV, V3, P445, DOI 10.1016/j.arr.2004.08.001
   Mittal VA, 2011, PSYCHIAT RES, V189, P158, DOI 10.1016/j.psychres.2011.06.006
   Mooy JM, 2000, DIABETES CARE, V23, P197, DOI 10.2337/diacare.23.2.197
   Okamura F, 2000, METABOLISM, V49, P1255, DOI 10.1053/meta.2000.9515
   PAFFENBARGER RS, 1994, ACTA PSYCHIAT SCAND, V89, P16, DOI 10.1111/j.1600-0447.1994.tb05796.x
   REBUFFESCRIVE M, 1988, J CLIN ENDOCR METAB, V67, P1122, DOI 10.1210/jcem-67-6-1122
   Rosmond R, 1998, OBES RES, V6, P338, DOI 10.1002/j.1550-8528.1998.tb00361.x
   Talbot F, 2000, DIABETES CARE, V23, P1556, DOI 10.2337/diacare.23.10.1556
   Tibblin G, 1990, Scand J Prim Health Care Suppl, V1, P33
   Vaynman S, 2005, NEUROREHAB NEURAL RE, V19, P283, DOI 10.1177/1545968305280753
   WING RR, 1991, ARTERIOSCLER THROMB, V11, P1250, DOI 10.1161/01.ATV.11.5.1250
NR 25
TC 32
Z9 36
U1 0
U2 5
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUN
PY 2007
VL 56
IS 6
BP 825
EP 829
DI 10.1016/j.metabol.2007.01.013
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 174BP
UT WOS:000246916500014
PM 17512316
DA 2025-06-11
ER

PT J
AU Fraser, SJ
   Brown, WJ
   Whiteford, HA
   Burton, NW
AF Fraser, Sarah J.
   Brown, Wendy J.
   Whiteford, Harvey A.
   Burton, Nicola W.
TI Impact of nurse-led behavioural counselling to improve metabolic health
   and physical activity among adults with mental illness
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE adult; mental health; metabolic health; physical activity counselling
ID CARDIOMETABOLIC RISK-FACTORS; TO-HEIGHT RATIO; ANTIPSYCHOTIC
   MEDICATIONS; PEOPLE; DISORDERS; INTERVENTIONS; INDIVIDUALS; CARE;
   SCHIZOPHRENIA; AUSTRALIANS
AB The life expectancy of adults with mental illness is significantly less than that of the general population, and this is largely due to poor physical health. Behavioural counselling can improve physical health indicators among people with non-communicable disease. This repeated-measures, single-group intervention trial evaluated the effects of a 19-week behavioural counselling programme on metabolic health indicators and physical activity levels of outpatient adults with mental illness. Sixteen participants completed the intervention that comprised individual face-to-face counselling sessions with a registered nurse every 3weeks, and progress reviews with a medical practitioner every 6weeks. Assessment included self-report and objective measurement of physical activity, and measures of blood pressure and anthropometry. Statistically-significant changes were demonstrated between baseline and post intervention for participants' waist circumference (P=0.035) and waist-to-height ratio (P=0.037). Non-significant improvements were demonstrated in weight and physical activity. The findings indicated that adults with mental illness can engage in a nurse-led behavioural counselling intervention, with improvements in some metabolic health measures after 19weeks. It is recommended that behavioural counselling programmes for adults with mental illness be sustained over time and have an open door' policy to allow for attendance interruptions, such as hospitalization.
C1 [Fraser, Sarah J.; Brown, Wendy J.; Burton, Nicola W.] Univ Queensland, Sch Human Movement & Nutr Sci, Brisbane, Qld, Australia.
   [Whiteford, Harvey A.] Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia.
C3 University of Queensland; University of Queensland
RP Fraser, SJ (corresponding author), Univ Queensland, Sch Human Movement & Nutr Sci, Level 5,Bldg 26B,Blair Dr, St Lucia, Qld 4072, Australia.
EM fraser.sarah17@gmail.com
RI Brown, Wendy/A-1553-2016; Whiteford, Harvey/A-4840-2009; Brown, Wendy
   J/G-2201-2010; Burton, Nicola/G-3313-2010
OI Whiteford, Harvey/0000-0003-4667-6623; Brown, Wendy
   J/0000-0001-9093-4509; Burton, Nicola/0000-0002-3221-2265; Fraser,
   Sarah/0000-0002-2602-0312
FU Toowong Private Hospital, Brisbane, Queensland, Australia
FX This study was supported by Toowong Private Hospital, Brisbane,
   Queensland, Australia, which provided gatekeeper approval to access
   their outpatient clinic.
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   [Anonymous], 2004, ACT AUSTR SURV GUID
   [Anonymous], 2014, Australias physical activity and sedentary behaviour guidelines
   [Anonymous], 2014, J SCI MED SPORT, DOI DOI 10.1016/J.JSAMS.2014.11.161
   Armstrong T., 2000, Physical Activity Patterns of Australian Adults. Results of the 1999 National Physical Activity Survey
   Ashwell M, 2012, OBES REV, V13, P275, DOI 10.1111/j.1467-789X.2011.00952.x
   Attux C, 2011, REV BRAS PSIQUIATR, V33, P117, DOI 10.1590/S1516-44462011000200005
   Attux C, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-60
   Australian Government Department of Health and Ageing National Health and Medical Research Council, 2013, EAT HLTH AUSTR DIET
   Black Dog Institute, 2012, EX DEPR FACTSH
   Bonfioli E, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-78
   Brown WJ, 2008, AUST NZ J PUBL HEAL, V32, P535, DOI 10.1111/j.1753-6405.2008.00305.x
   Cabassa LJ, 2010, PSYCHIAT SERV, V61, P774, DOI 10.1176/ps.2010.61.8.774
   Charlson FJ, 2015, EPIDEMIOL PSYCH SCI, V24, P121, DOI 10.1017/S2045796014000687
   Correll CU, 2009, JAMA-J AM MED ASSOC, V302, P1765, DOI 10.1001/jama.2009.1549
   Firth J, 2015, PSYCHOL MED, V45, P1343, DOI 10.1017/S0033291714003110
   Galletly CA, 2012, AUST NZ J PSYCHIAT, V46, P753, DOI 10.1177/0004867412453089
   Gorczynski P, 2014, MENT HEALTH PHYS ACT, V7, P191, DOI 10.1016/j.mhpa.2014.04.002
   Green CA, 2015, AM J PSYCHIAT, V172, P71, DOI 10.1176/appi.ajp.2014.14020173
   Happell B, 2011, INT J MENT HEALTH NU, V20, P310, DOI 10.1111/j.1447-0349.2010.00732.x
   Happell B, 2012, INT J MENT HEALTH NU, V21, P236, DOI 10.1111/j.1447-0349.2012.00816.x
   International Diabetes Federation, 2009, INT DIAB FED WORLDW
   John AP, 2009, MED J AUSTRALIA, V190, P176, DOI 10.5694/j.1326-5377.2009.tb02342.x
   Josefsson T, 2014, SCAND J MED SCI SPOR, V24, P259, DOI 10.1111/sms.12050
   Kalarchian MA, 2005, J CLIN PSYCHIAT, V66, P1058, DOI 10.4088/JCP.v66n0815
   Kerse N, 2005, J AM GERIATR SOC, V53, P1951, DOI 10.1111/j.1532-5415.2005.00466.x
   Kirk A, 2004, DIABETOLOGIA, V47, P821, DOI 10.1007/s00125-004-1396-5
   Knight M, 2015, ISSUES MENT HEALTH N, V36, P464, DOI 10.3109/01612840.2014.997845
   Lawrence D, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f2539
   McPhail S, 2012, BMC FAM PRACT, V13, DOI 10.1186/1471-2296-13-31
   Meriwether RA, 2008, AM FAM PHYSICIAN, V77, P1129
   O'Halloran PD, 2014, CLIN REHABIL, V28, P1159, DOI 10.1177/0269215514536210
   Peterson JA, 2007, J AM ACAD NURSE PRAC, V19, P349, DOI 10.1111/j.1745-7599.2007.00239.x
   Richards J., 2013, Cochrane Database of Systematic Reviews, V9, P1
   Rosenbaum S, 2016, AUSTRALAS PSYCHIATRY, V24, P49, DOI 10.1177/1039856215590252
   Savva SC, 2013, DIABET METAB SYND OB, V6, P403, DOI 10.2147/DMSO.S34220
   Scott D, 2012, AUST NZ J PUBL HEAL, V36, P483, DOI 10.1111/j.1753-6405.2012.00916.x
   Scott David, 2011, Issues Ment Health Nurs, V32, P589, DOI 10.3109/01612840.2011.569846
   Troiano RP, 2008, MED SCI SPORT EXER, V40, P181, DOI 10.1249/mss.0b013e31815a51b3
   Vancampfort D, 2015, AUST NZ J PSYCHIAT, V49, P681, DOI 10.1177/0004867415590831
NR 40
TC 9
Z9 9
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD APR
PY 2018
VL 27
IS 2
BP 619
EP 630
DI 10.1111/inm.12343
PG 12
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA GA5ZR
UT WOS:000428413100013
PM 28466504
DA 2025-06-11
ER

PT J
AU Huang, CH
   Huang, TJ
   Lin, YC
   Lin, CN
   Chen, MY
AF Huang, Cheng-Hsien
   Huang, Tung-Jung
   Lin, Yu-Chih
   Lin, Chia-Ni
   Chen, Mei-Yen
TI Factors Associated with Urinary 1-Hydroxypyrene and Malondialdehyde
   among Adults near a Petrochemical Factory: Implications for Sex and
   Lifestyle Modification
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE 1-hydroxypyrene (1-OHP); malondialdehyde (MDA); HBsAg (hepatitis B
   surface antigen); anti-HCV (hepatitis C virus); petrochemical industrial
   complex; health promotion
ID OXIDATIVE STRESS; EXPOSURE; POPULATION; SMOKE
AB Background: The association between the biomarkers of environmental exposure, oxidative stress, and health-related behaviors in community residents living in an endemic viral hepatitis area and near petrochemical industrial complexes remains unclear. From a health promotion perspective, healthcare providers must know what to do for residents concerned about their health and living environment, especially for individual-level and modifiable risk factors. Therefore, we aimed to explore the factors associated with urinary 1-hydroxypyrene (1-OHP) and malondialdehyde (MDA). Methods: A community-based, cross-sectional study was conducted between July 2018 and February 2019 in western coastal Yunlin County, Taiwan. All participants lived within a 10 km radius of a large petrochemical complex and did not work in the factory. This study was conducted with the local hospital through annual community health screening. Biological samples were collected and biomarkers determined and quantified in the central laboratory of the collaborating hospital. Results: A total of 6335 adult residents completed the study. The mean age was 47.7 (SD = 16) years. Out of the total population, 56.4% were female, 30.1% had metabolic syndrome (MetS), and 16.8% and 14.3% had hepatitis B virus antigen (HBsAg) and hepatitis C virus antibody (anti-HCV) positivity, respectively. The median 1-OHP and MDA level was 0.11 and 0.9 mu g/g creatinine with an interquartile range of 0.07-0.18, and 0.4-1.5, respectively. The MDA levels correlated with specific diseases. The multivariable ordinal logistic regression model revealed that female sex, smoking, betel nut use, HBsAg, and anti-HCV positivity were associated with higher 1-OHP levels. In men, MetS was associated with higher 1-OHP levels and regular exercise with lower 1-OHP levels. High MDA levels were associated with smoking, betel nut users, HBsAg, and anti-HCV positivity. Conclusions: The findings highlight the importance of initiating individualized health promotion programs for residents near petrochemical factories, especially for adults with substance-use and cardiometabolic risk factors. Furthermore, it is crucial to provide further treatment to patients with viral hepatitis.
C1 [Huang, Cheng-Hsien] Chang Gung Mem Hosp, Dept Family Med, Chiayi 613, Taiwan.
   [Huang, Tung-Jung] Chang Gung Mem Hosp, Dept Pulm Dis & Crit Care, Mailiao 638, Yunlin, Taiwan.
   [Huang, Tung-Jung] Chang Gung Univ Sci & Technol, Dept Resp Care, Chiayi 613, Taiwan.
   [Lin, Yu-Chih] Chang Gung Mem Hosp, Dept Family Med, Mailiao 638, Yunlin, Taiwan.
   [Lin, Chia-Ni] Chang Gung Mem Hosp, Dept Lab Med, Taoyuan 333, Taiwan.
   [Lin, Chia-Ni] Chang Gung Univ, Dept Med Biotechnol & Lab Sci, Taoyuan 333, Taiwan.
   [Chen, Mei-Yen] Chang Gung Univ Sci & Technol, Dept Nursing, Chiayi 613, Taiwan.
   [Chen, Mei-Yen] Chang Gung Univ, Sch Nursing, Taoyuan 333, Taiwan.
   [Chen, Mei-Yen] Chang Gung Mem Hosp, Dept Cardiol, Chiayi 613, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung Memorial Hospital; Chang Gung
   University of Science & Technology; Chang Gung Memorial Hospital; Chang
   Gung Memorial Hospital; Chang Gung University; Chang Gung University of
   Science & Technology; Chang Gung University; Chang Gung Memorial
   Hospital
RP Chen, MY (corresponding author), Chang Gung Univ Sci & Technol, Dept Nursing, Chiayi 613, Taiwan.; Chen, MY (corresponding author), Chang Gung Univ, Sch Nursing, Taoyuan 333, Taiwan.; Chen, MY (corresponding author), Chang Gung Mem Hosp, Dept Cardiol, Chiayi 613, Taiwan.
EM shien36@cgmh.org.tw; donaldhuang@cgmh.org.tw; riverpig@cgmh.org.tw;
   chianilin@cgmh.org.tw; meiyen@mail.cgust.edu.tw
RI Chen, Kang-Hua/GLR-9451-2022
OI Chen, Mei-Yen/0000-0002-8980-1300; Lin, Yu-Chih/0000-0002-1190-406X;
   Lin, Chia-Ni/0000-0002-2722-0164
FU Taiwan Formosa Plastic Group (FCRP) [F6L0011]; Chang Gung Memorial
   Hospital [NMRPF6H0043]
FX The study was supported by a grant from Taiwan Formosa Plastic Group
   (FCRP F6L0011) and Chang Gung Memorial Hospital (NMRPF6H0043).
CR Ahmad S, 2018, JAMA NETW OPEN, V1, DOI 10.1001/jamanetworkopen.2018.5708
   Akanji MA, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/9971885
   Alavian SM, 2016, HEPAT MON, V16, DOI 10.5812/hepatmon.37973
   Barrera G, 2018, ANTIOXIDANTS-BASEL, V7, DOI 10.3390/antiox7080102
   Caliri AW, 2021, MUTAT RES-REV MUTAT, V787, DOI 10.1016/j.mrrev.2021.108365
   Chan CC, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10081323
   Chang WW, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17072474
   Chen IC, 2014, J CELL BIOCHEM, V115, P328, DOI 10.1002/jcb.24667
   Chen MY, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18052514
   Ding YS, 2014, INT J ENV RES PUB HE, V11, P11898, DOI 10.3390/ijerph111111898
   Domingo JL, 2020, ENVIRON RES, V186, DOI 10.1016/j.envres.2020.109495
   Elpek GO, 2021, WORLD J CLIN CASES, V9, P4890, DOI 10.12998/wjcc.v9.i19.4890
   Environmental Protection Administration, EPA ENV WHIT PAP
   Fedeli U, 2019, WORLD J GASTROENTERO, V25, P4885, DOI 10.3748/wjg.v25.i33.4885
   Gearhart-Serna LM, 2021, ENVIRON RES, V201, DOI 10.1016/j.envres.2021.111614
   Guo SE, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-257
   Health Promotion Administration, HPA MET SYNDR
   Hoseini M, 2018, ENVIRON POLLUT, V240, P781, DOI 10.1016/j.envpol.2018.04.077
   Ivanov AV, 2017, ONCOTARGET, V8, P3895, DOI 10.18632/oncotarget.13904
   Jain RB, 2020, ENVIRON POLLUT, V266, DOI 10.1016/j.envpol.2020.115178
   Jephcote C, 2020, ENVIRON HEALTH-GLOB, V19, DOI 10.1186/s12940-020-00582-1
   Keir JLA, 2021, J EXPO SCI ENV EPID, V31, P386, DOI 10.1038/s41370-020-0208-4
   Lechner K, 2020, EUR J PREV CARDIOL, V27, P394, DOI 10.1177/2047487319869400
   Li W, 2020, BMC INFECT DIS, V20, DOI 10.1186/s12879-020-05435-3
   Lin CK, 2017, ENVIRON HEALTH-GLOB, V16, DOI 10.1186/s12940-017-0309-2
   Lin YC, 2020, J NURS SCHOLARSHIP, V52, P128, DOI 10.1111/jnu.12533
   Masarone M, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/9547613
   National Health Insurance, NHI HEP C FULL OR NE
   Paliogiannis P, 2018, BIOMARK MED, V12, P771, DOI 10.2217/bmm-2017-0420
   Patel AP, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0252719
   Pinna A, 2020, RETINA-J RET VIT DIS, V40, P195, DOI 10.1097/IAE.0000000000002574
   Poznyak A, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21051835
   Ranasinghe P, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4041-1
   Senerat AM, 2021, J CLIN TRANSL SCI, V5, DOI 10.1017/cts.2020.532
   Sharma T, 2021, J FAM MED PRIM CARE, V10, P1804, DOI 10.4103/jfmpc.jfmpc_1397_20
   Singh A, 2018, OCCUP MED-OXFORD, V68, P255, DOI 10.1093/occmed/kqy049
   Taiwan Medical Association, TMA HEP C EP PREV ST
   Tombolini F, 2018, ENVIRON SCI POLLUT R, V25, P28772, DOI 10.1007/s11356-018-1650-x
   Uchida D, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061576
   Wang JH, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10010077
   Wu PS, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16244981
   Yegorov YE, 2020, BIOMEDICINES, V8, DOI 10.3390/biomedicines8070198
   Yuan T, 2019, REDOX BIOL, V20, P247, DOI 10.1016/j.redox.2018.09.025
   Yuan TH, 2020, ENVIRON POLLUT, V256, DOI 10.1016/j.envpol.2019.113457
   Zhou B, 2018, TOB INDUC DIS, V16, DOI 10.18332/tid/90004
   Zhu HK, 2021, ENVIRON INT, V156, DOI 10.1016/j.envint.2021.106720
NR 46
TC 0
Z9 0
U1 1
U2 5
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD FEB
PY 2022
VL 19
IS 3
AR 1362
DI 10.3390/ijerph19031362
PG 13
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA ZC2YL
UT WOS:000757391700001
PM 35162385
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Treloar, V
AF Treloar, Valori
TI Integrative dermatology for psoriasis: facts and controversies
SO CLINICS IN DERMATOLOGY
LA English
DT Article
ID BODY-MASS INDEX; METABOLIC SYNDROME; CLINICAL SEVERITY;
   CIGARETTE-SMOKING; NURSES HEALTH; RISK-FACTOR; TNF-ALPHA; FISH-OIL;
   STRESS; EXERCISE
AB Recommendations for changes in diet and lifestyle are not meant to supplant conventional therapy but to integrate with it and, hopefully, improve response to treatment. At the same time, integrative approaches permit the patient to depend less on more expensive and potentially harmful pharmaceutical and medical approaches. Manipulation of diet and lifestyle may actually diminish the effect of underlying predisposing or etiologic factors and simultaneously treat serious comorbidities. Topics include alcohol, smoking, body composition, sleep and stress, diet and nutrients, and exercise. (C) 2010 Published by Elsevier Inc.
C1 Integrat Dermatol, Newton, MA 02461 USA.
RP Treloar, V (corresponding author), Integrat Dermatol, 1172 Beacon St,Ste 402, Newton, MA 02461 USA.
EM trescon@rcn.com
CR ADAM K, 1986, J PSYCHIATR RES, V20, P301, DOI 10.1016/0022-3956(86)90033-6
   ALABADIE MS, 1994, BRIT J DERMATOL, V130, P199, DOI 10.1111/j.1365-2133.1994.tb02900.x
   Altemus M, 2001, J INVEST DERMATOL, V117, P309, DOI 10.1046/j.1523-1747.2001.01373.x
   Serwin AB, 2007, PHOTODERMATOL PHOTO, V23, P130, DOI 10.1111/j.1600-0781.2007.00296.x
   Behnam Shahrad M, 2005, Skinmed, V4, P174
   Behnam SM, 2005, CUTIS, V76, P181
   Bernstein CN, 2005, GASTROENTEROLOGY, V129, P827, DOI 10.1053/j.gastro.2005.06.021
   Bo K, 2008, DERMATOLOGY, V216, P40, DOI 10.1159/000109357
   Boehncke S, 2007, BRIT J DERMATOL, V157, P1249, DOI 10.1111/j.1365-2133.2007.08190.x
   Cao GH, 1998, AM J CLIN NUTR, V68, P1081, DOI 10.1093/ajcn/68.5.1081
   Danno Kiichiro, 1998, Journal of Dermatology (Tokyo), V25, P703
   Fortes C, 2005, ARCH DERMATOL, V141, P1580, DOI 10.1001/archderm.141.12.1580
   GASTON L, 1987, J AM ACAD DERMATOL, V17, P82, DOI 10.1016/S0190-9622(87)70176-5
   Gomez-Cabrera MC, 2008, FREE RADICAL BIO MED, V44, P126, DOI 10.1016/j.freeradbiomed.2007.02.001
   Grimble RF, 2002, AM J CLIN NUTR, V76, P454, DOI 10.1093/ajcn/76.2.454
   GUPTA AK, 1989, BRIT J DERMATOL, V120, P801, DOI 10.1111/j.1365-2133.1989.tb01378.x
   Harvima RJ, 1996, ACTA DERM-VENEREOL, V76, P467
   Hawley JA, 2008, ACTA PHYSIOL, V192, P127, DOI 10.1111/j.1748-1716.2007.01783.x
   HEALEY ES, 1981, PSYCHOSOM MED, V43, P439
   JANCIN B, 2007, SKIN ALLERGY NEWS, P9
   Johnston A, 2008, BRIT J DERMATOL, V159, P342, DOI 10.1111/j.1365-2133.2008.08655.x
   Kabat-Zinn J, 1998, PSYCHOSOM MED, V60, P625, DOI 10.1097/00006842-199809000-00020
   Kallio P, 2007, AM J CLIN NUTR, V85, P1417, DOI 10.1093/ajcn/85.5.1417
   Keylock KT, 2008, AM J PHYSIOL-REG I, V294, pR179, DOI 10.1152/ajpregu.00177.2007
   Kia KF, 2007, AM J CLIN DERMATOL, V8, P301, DOI 10.2165/00128071-200708050-00005
   Kirby B, 2008, BRIT J DERMATOL, V158, P138, DOI 10.1111/j.1365-2133.2007.08299.x
   Kourosh A S, 2008, Skin Therapy Lett, V13, P1
   Krämer U, 2006, J INVEST DERMATOL, V126, P693, DOI 10.1038/sj.jid.5700161
   Kural BV, 2003, CLIN CHIM ACTA, V328, P71, DOI 10.1016/S0009-8981(02)00373-X
   Lam Janet C, 2007, Curr Treat Options Neurol, V9, P404, DOI 10.1007/s11940-007-0042-1
   LANDS WEM, 1992, FASEB J, V6, P2530, DOI 10.1096/fasebj.6.8.1592205
   LEIBOWITZ E, 1991, BRIT J DERMATOL, V124, P439, DOI 10.1111/j.1365-2133.1991.tb00622.x
   Mayser P, 2002, BRIT J NUTR, V87, pS77, DOI 10.1079/BJN2001459
   MCFADDEN JP, 1990, CLIN EXP DERMATOL, V15, P39, DOI 10.1111/j.1365-2230.1990.tb02017.x
   McKeown NM, 2004, DIABETES CARE, V27, P538, DOI 10.2337/diacare.27.2.538
   Meerlo P, 2008, SLEEP MED REV, V12, P197, DOI 10.1016/j.smrv.2007.07.007
   Michaëlsson G, 2006, J AM ACAD DERMATOL, V54, P737, DOI 10.1016/j.jaad.2005.07.024
   MICHAELSSON G, 1993, BRIT J DERMATOL, V129, P667, DOI 10.1111/j.1365-2133.1993.tb03329.x
   Michaëlsson G, 2000, BRIT J DERMATOL, V142, P44, DOI 10.1046/j.1365-2133.2000.03240.x
   Naldi L, 1996, BRIT J DERMATOL, V134, P101, DOI 10.1111/j.1365-2133.1996.tb07846.x
   Naldi L, 2005, J INVEST DERMATOL, V125, P61, DOI 10.1111/j.0022-202X.2005.23681.x
   Nasreen S, 2008, JCPSP-J COLL PHYSICI, V18, P397, DOI 06.2008/JCPSP.397400
   Parker J, 2004, J AM ACAD DERMATOL, V51, P919, DOI 10.1016/j.jaad.2004.08.042
   Picardi A, 2005, PSYCHOSOMATICS, V46, P556, DOI 10.1176/appi.psy.46.6.556
   POIKOLAINEN K, 1990, BMJ-BRIT MED J, V300, P780, DOI 10.1136/bmj.300.6727.780
   Reynoso-von Drateln C, 2003, J AM ACAD DERMATOL, V48, P882, DOI 10.1067/mjd.2003.446
   ROEHR B, 2008, DERMATOL TIMES, P41
   SANTANA MG, 2008, ASS PROF SLEEP SOC M
   Serwin AB, 2008, J EUR ACAD DERMATOL, V22, P712, DOI 10.1111/j.1468-3083.2008.02584.x
   Setty AR, 2007, ARCH INTERN MED, V167, P1670, DOI 10.1001/archinte.167.15.1670
   Setty AR, 2007, AM J MED, V120, P953, DOI 10.1016/j.amjmed.2007.06.020
   Smith TP, 2006, EXERC IMMUNOL REV, V12, P86
   Sterry W, 2007, BRIT J DERMATOL, V157, P649, DOI 10.1111/j.1365-2133.2007.08068.x
   Swinburn BA, 1998, AM J PUBLIC HEALTH, V88, P288, DOI 10.2105/AJPH.88.2.288
   Tanaka S, 2001, CLIN ENDOCRINOL, V54, P347, DOI 10.1046/j.1365-2265.2001.1139/cn2155.x
   Zheng GY, 2004, ACTA BIOCH BIOPH SIN, V36, P597, DOI 10.1093/abbs/36.9.597
NR 56
TC 12
Z9 12
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0738-081X
EI 1879-1131
J9 CLIN DERMATOL
JI Clin. Dermatol.
PD JAN-FEB
PY 2010
VL 28
IS 1
BP 93
EP 99
DI 10.1016/j.clindermatol.2009.03.016
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 619JB
UT WOS:000279425300018
PM 20082958
DA 2025-06-11
ER

PT J
AU Masuda, H
   Sato, A
   Miyata, K
   Shizuno, T
   Oyamada, A
   Ishiwata, K
   Nakagawa, Y
   Asahara, T
AF Masuda, Haruchika
   Sato, Atsuko
   Miyata, Kumiko
   Shizuno, Tomoko
   Oyamada, Akira
   Ishiwata, Kazuo
   Nakagawa, Yoshihiro
   Asahara, Takayuki
TI Drinking Molecular Hydrogen Water Is Beneficial to Cardiovascular
   Function in Diet-Induced Obesity Mice
SO BIOLOGY-BASEL
LA English
DT Article
DE obesity; molecular hydrogen; brown adipose tissue; white adipose tissue;
   cardiovascular disorders; metabolic syndrome
ID BROWN ADIPOSE-TISSUE; RICH WATER; METABOLIC SYNDROME; ENERGY-METABOLISM;
   GENE-EXPRESSION; ANTIOXIDANT; INJURY; CELLS; MOUSE; REPERFUSION
AB Simple Summary
   Molecular hydrogen (MH) reportedly exerts therapeutic effects against inflammatory diseases by alleviating oxidative stress. We investigated the cardiovascular protective effects of molecular hydrogen water (MHW) intake using high-fat diet-induced obesity (DIO) mice. We observed that MHW intake for 2 weeks did not improve the blood sugar level or body weight but decreased heart weight in DIO mice. Notably, MHW intake alleviated oxidative stress in both the heart and the adipose tissue. Moreover, it improved cardiac hypertrophy and restored left ventricular function in DIO mice, and promoted the histological conversion of energy storage to expenditure in adipose tissues with the upregulation of thermogenic and cardiovascular protective genes. Furthermore, MHW restored endothelial progenitor cell (EPC) bioactivity to maintain vascular homeostasis. Taken together, MHW intake exerts cardiovascular protective effects in DIO mice. Hence, MHW intake is a potential prophylactic strategy against cardiovascular disorders in metabolic syndrome.
   Molecular hydrogen (MH) reportedly exerts therapeutic effects against inflammatory diseases as a suppressor of free radical chain reactions. Here, the cardiovascular protective effects of the intake of molecular hydrogen water (MHW) were investigated using high-fat diet-induced obesity (DIO) mice. MHW was prepared using supplier sticks and degassed water as control. MHW intake for 2 weeks did not improve blood sugar or body weight but decreased heart weight in DIO mice. Moreover, MHW intake improved cardiac hypertrophy, shortened the width of cardiomyocytes, dilated the capillaries and arterioles, activated myocardial eNOS-Ser-1177 phosphorylation, and restored left ventricular function in DIO mice. MHW intake promoted the histological conversion of hypertrophy to hyperplasia in white and brown adipose tissues (WAT and BAT) with the upregulation of thermogenic and cardiovascular protective genes in BAT (i.e., Ucp-1, Vegf-a, and eNos). Furthermore, the results of a colony formation assay of bone-marrow-derived endothelial progenitor cells (EPCs) indicated that MHW activated the expansion, differentiation, and mobilization of EPCs to maintain vascular homeostasis. These findings indicate that the intake of MHW exerts cardiovascular protective effects in DIO mice. Hence, drinking MHW is a potential prophylactic strategy against cardiovascular disorders in metabolic syndrome.
C1 [Masuda, Haruchika; Sato, Atsuko; Miyata, Kumiko; Shizuno, Tomoko; Ishiwata, Kazuo] Tokai Univ, Sch Med, Dept Physiol, 143 Shimokasuya, Isehara, Kanagawa 2591193, Japan.
   [Oyamada, Akira; Asahara, Takayuki] Tokai Univ, Sch Med, Dept Innovat Med Sci, 143 Shimokasuya, Isehara, Kanagawa 2591193, Japan.
   [Nakagawa, Yoshihiro] Tokai Univ, Sch Med, Dept Opthalmol, 143 Shimokasuya, Isehara, Kanagawa 2591193, Japan.
C3 Tokai University; Tokai University; Tokai University
RP Masuda, H (corresponding author), Tokai Univ, Sch Med, Dept Physiol, 143 Shimokasuya, Isehara, Kanagawa 2591193, Japan.
EM masu3510@is.icc.u-tokai.ac.jp; asato@tsc.u-tokai.ac.jp;
   miyata.kumiko@tsc.u-tokai.ac.jp; shizuno@tsc.u-tokai.ac.jp;
   a.oya.lab@gmail.com; ishiwata@jeff.co.jp; nakayosi@is.icc.u-tokai.ac.jp;
   asa777@is.icc.u-tokai.ac.jp
FU Tokai Univ. School of Medicine Research Aid; Tokai University General
   Research Organization Grant
FX This work was supported by Tokai Univ. School of Medicine Research Aid
   for H.M., and Tokai University General Research Organization Grant.
CR Asada R, 2020, MED GAS RES, V10, P114, DOI 10.4103/2045-9912.296041
   Asada R, 2019, MED GAS RES, V9, P68, DOI 10.4103/2045-9912.260647
   Berezin AE, 2020, FRONT CARDIOVASC MED, V7, DOI 10.3389/fcvm.2020.583175
   Boon MR, 2015, CRIT REV CL LAB SCI, V52, P150, DOI 10.3109/10408363.2014.1003634
   Chen ZF, 2015, INT J CLIN EXP PATHO, V8, P4614
   Choe SS, 2016, FRONT ENDOCRINOL, V7, DOI 10.3389/fendo.2016.00030
   Conceicao Gloria, 2020, Cell Physiol Biochem, V54, P384, DOI 10.33594/000000226
   Ding ZH, 2021, ACS BIOMATER SCI ENG, V7, P727, DOI 10.1021/acsbiomaterials.0c01181
   Dlasková A, 2010, BBA-BIOENERGETICS, V1797, P1470, DOI 10.1016/j.bbabio.2010.04.008
   Fadini GP, 2009, ATHEROSCLEROSIS, V207, P213, DOI 10.1016/j.atherosclerosis.2009.03.040
   Fox CS, 2007, CIRCULATION, V116, P39, DOI 10.1161/CIRCULATIONAHA.106.675355
   François M, 2016, NUTRITION, V32, P709, DOI 10.1016/j.nut.2015.12.034
   Gao Shumin, 2011, Curr Protoc Mouse Biol, V1, P71
   Harms M, 2013, NAT MED, V19, P1252, DOI 10.1038/nm.3361
   Hayashida K, 2008, BIOCHEM BIOPH RES CO, V373, P30, DOI 10.1016/j.bbrc.2008.05.165
   Iuchi K, 2016, SCI REP-UK, V6, DOI 10.1038/srep18971
   Jackson K, 2018, WORLD J GASTROENTERO, V24, P5095, DOI 10.3748/wjg.v24.i45.5095
   Kajiyama S, 2008, NUTR RES, V28, P137, DOI 10.1016/j.nutres.2008.01.008
   Kamimura N, 2016, NPJ AGING MECH DIS, V2, DOI 10.1038/npjamd.2016.8
   Kamimura N, 2011, OBESITY, V19, P1396, DOI 10.1038/oby.2011.6
   Kang KM, 2011, MED GAS RES, V1, DOI 10.1186/2045-9912-1-11
   Kharitonenkov A, 2005, J CLIN INVEST, V115, P1627, DOI 10.1172/JCI23606
   Koyama Y, 2014, HEPATOL RES, V44, P663, DOI 10.1111/hepr.12165
   LeBaron TW, 2020, DIABETES METAB SYNDR, V13, P889, DOI 10.2147/DMSO.S240122
   MacDougall DA, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00203
   Matsumoto A, 2013, SCI REP-UK, V3, DOI 10.1038/srep03273
   Nakao A, 2010, J CLIN BIOCHEM NUTR, V46, P140, DOI 10.3164/jcbn.09-100
   Nishikawa T, 2000, NATURE, V404, P787, DOI 10.1038/35008121
   Ohsawa I, 2007, NAT MED, V13, P688, DOI 10.1038/nm1577
   Ohta S, 2021, CURR PHARM DESIGN, V27, P595, DOI 10.2174/1381612826666200806101137
   Ohta S, 2011, CURR PHARM DESIGN, V17, P2241, DOI 10.2174/138161211797052664
   Palomer X, 2013, INT J CARDIOL, V168, P3160, DOI 10.1016/j.ijcard.2013.07.150
   Peng XF, 2015, J DIABETES COMPLICAT, V29, P755, DOI 10.1016/j.jdiacomp.2015.04.012
   Petrovic V, 2010, COMP BIOCHEM PHYS C, V152, P147, DOI 10.1016/j.cbpc.2010.03.008
   Picoli CD, 2020, J APPL PHYSIOL, V129, P66, DOI 10.1152/japplphysiol.00742.2019
   Reitman ML, 2007, CELL METAB, V5, P405, DOI 10.1016/j.cmet.2007.05.010
   Segal MS, 2006, DIABETES, V55, P102, DOI 10.2337/diabetes.55.01.06.db05-0803
   Song GH, 2013, J LIPID RES, V54, P1884, DOI 10.1194/jlr.M036640
   Song GH, 2012, ATHEROSCLEROSIS, V221, P55, DOI 10.1016/j.atherosclerosis.2011.11.043
   Thoonen R, 2016, AM J PHYSIOL-HEART C, V310, pH1592, DOI 10.1152/ajpheart.00698.2015
   Thoonen R, 2015, J MOL CELL CARDIOL, V84, P202, DOI 10.1016/j.yjmcc.2015.05.002
   Tiwari S, 2014, CURR PHARM DESIGN, V20, P1409, DOI 10.2174/13816128113199990562
   Tran TT, 2010, NAT REV ENDOCRINOL, V6, P195, DOI 10.1038/nrendo.2010.20
   Tsukada S, 2013, STEM CELL RES THER, V4, DOI 10.1186/scrt168
   Wang Yue-hui, 2006, Zhong Nan Da Xue Xue Bao Yi Xue Ban, V31, P814
   Wu F, 2015, CARDIOVASC PATHOL, V24, P294, DOI 10.1016/j.carpath.2015.04.008
   Wu J, 2012, CELL, V150, P366, DOI 10.1016/j.cell.2012.05.016
   Wu QF, 2015, J SURG RES, V199, P664, DOI 10.1016/j.jss.2015.06.017
   Xin HG, 2014, MOL CELL BIOCHEM, V392, P117, DOI 10.1007/s11010-014-2024-4
   Yang NN, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0138832
   Yang QX, 2017, MOL CLIN ONCOL, V7, P891, DOI 10.3892/mco.2017.1409
   Zou TD, 2018, J NUTR BIOCHEM, V55, P157, DOI 10.1016/j.jnutbio.2018.02.005
NR 52
TC 5
Z9 6
U1 0
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2079-7737
J9 BIOLOGY-BASEL
JI Biology-Basel
PD MAY
PY 2021
VL 10
IS 5
AR 364
DI 10.3390/biology10050364
PG 18
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA SG4JF
UT WOS:000653406600001
PM 33922704
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Stamu-O'Brien, C
   Kroumpouzos, G
AF Stamu-O'Brien, Caroline
   Kroumpouzos, George
TI The role of lipids in vitiligo and schizophrenia
SO CLINICS IN DERMATOLOGY
LA English
DT Article
ID ADJUNCTIVE THERAPY; OXIDATIVE STRESS; FATTY-ACIDS; STATINS;
   PATHOGENESIS; CHOLESTEROL; METABOLISM; DISORDERS; DISEASE; CELLS
AB The pathogenesis of vitiligo and schizophrenia has not been adequately clarified. We explore the role of lipids in these diseases. Both conditions have been associated with stress in several observations and studies. Research data indicate complex interactions between oxidative stress and metabolic syndrome-with lipid abnormalities being a significant component of the latter-in these diseases. The impaired membrane lipid homeostasis mechanism is related to the increased phospholipid remodeling caused by excessive oxidative stress in schizophrenia. We indicate that sphingomyelin is possibly involved in the pathogenesis of these diseases. Statins have anti-inflammatory and immunomodulating effects and an effect against oxidative stress. Preliminary clinical studies show that these agents may be beneficial in both vitiligo and schizophrenia, but their therapeutic value should be studied further. (c) 2023 Elsevier Inc. All rights reserved.
C1 [Stamu-O'Brien, Caroline] NYU, Sch Med, Dept Psychiat, New York, NY USA.
   [Kroumpouzos, George] Brown Univ, Warren Alpert Med Sch, Dept Dermatol, Providence, RI 02912 USA.
C3 New York University; Brown University
RP Kroumpouzos, G (corresponding author), Brown Univ, Warren Alpert Med Sch, Dept Dermatol, Providence, RI 02912 USA.
EM gk@gkderm.com
RI Stamu-O'Brien, Caroline/AAX-3745-2021; Kroumpouzos, George/P-1301-2015
CR Adami M, 2012, J DERMATOL SCI, V66, P127, DOI 10.1016/j.jdermsci.2012.02.015
   Azpiazu I, 2002, METHOD ENZYMOL, V344, P112
   Benros ME, 2014, AM J PSYCHIAT, V171, P218, DOI 10.1176/appi.ajp.2013.13010086
   Berger GE, 2002, AUST NZ J PSYCHIAT, V36, P355, DOI 10.1046/j.1440-1614.2001.01021.x
   Bergqvist C, 2020, DERMATOLOGY, V236, P571, DOI 10.1159/000506103
   Chang YQ, 2017, J INVEST DERMATOL, V137, P1286, DOI 10.1016/j.jid.2017.01.020
   Chen JR, 2021, MED RES REV, V41, P1138, DOI 10.1002/med.21754
   Chen Y, 2019, INT REV IMMUNOL, V38, P249, DOI 10.1080/08830185.2019.1645138
   Correll CU, 2014, J CLIN PSYCHIAT, V75, P347, DOI 10.4088/JCP.13078co8c
   Dell'Anna ML, 2007, J INVEST DERMATOL, V127, P1226, DOI 10.1038/sj.jid.5700700
   Dell'Anna ML, 2010, J CELL PHYSIOL, V223, P187, DOI 10.1002/jcp.22027
   Derakhshandeh-Rishehri SM, 2019, INT J PREVENTIVE MED, V10, DOI 10.4103/ijpvm.IJPVM_47_17
   El-Sayed MIK, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00197
   Ezzedine K, 2021, AM J CLIN DERMATOL, V22, P757, DOI 10.1007/s40257-021-00631-6
   Farag AGA, 2022, AN BRAS DERMATOL, V97, P28, DOI 10.1016/j.abd.2021.04.014
   Gault CR, 2010, ADV EXP MED BIOL, V688, P1
   George A, 2018, INDIAN J PSYCHIAT, V60, P213, DOI 10.4103/psychiatry.IndianJPsychiatry_156_18
   Haendeler J, 2004, CIRCULATION, V110, P856, DOI 10.1161/01.CIR.0000138743.09012.93
   Hanssens L, 2007, INT CLIN PSYCHOPHARM, V22, P43
   Hsu MC, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-01337-0
   Johnson JD, 2019, J ENDOCR SOC, V3, P1302, DOI 10.1210/js.2019-00053
   Kadhim SS, 2019, DENT HYPOTHESES, V10, P70, DOI 10.4103/denthyp.denthyp_60_19
   Kim SW, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00103
   Kobashigawa JA, 2001, LIVER TRANSPLANT, V7, P559, DOI 10.1053/jlts.2001.0070559
   Kralisch S, 2013, DIABETOLOGIA, V56, P10, DOI 10.1007/s00125-012-2737-4
   Li MH, 2022, SCHIZOPHRENIA BULL, V48, P1125, DOI 10.1093/schbul/sbac011
   Li NN, 2022, SCHIZOPHRENIA-UK, V8, DOI 10.1038/s41537-022-00214-2
   McPhie ML, 2021, DERMATOLOGY, V237, P248, DOI 10.1159/000508868
   Metta AK, 2016, INT J MED SCI PUBLIC, V5, P493
   Nguyen S, 2018, JAMA DERMATOL, V154, P725, DOI 10.1001/jamadermatol.2017.6401
   Noel Martin, 2004, Lipids Health Dis, V3, P7, DOI 10.1186/1476-511X-3-7
   Nordlund James J, 2011, Indian J Dermatol, V56, P180, DOI 10.4103/0019-5154.80413
   Patel KR, 2019, J EUR ACAD DERMATOL, V33, P191, DOI 10.1111/jdv.15255
   Pietrzak A, 2014, ACTA DERMATOVENER CR, V22, P19
   Raikhy S, 2017, ASIAN J PSYCHIATR, V29, P85, DOI 10.1016/j.ajp.2017.04.018
   Rashighi M, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3007811
   Shen H, 2018, PSYCHIAT RES, V262, P84, DOI 10.1016/j.psychres.2018.02.018
   Silvan M, 2004, CUTIS, V73, P163
   Sommer IE, 2021, SCHIZOPHRENIA BULL, V47, P1108, DOI 10.1093/schbul/sbab010
   Tanacan E, 2020, AN BRAS DERMATOL, V95, P165, DOI 10.1016/j.abd.2019.07.006
   Taneja K, 2020, CLIN LAB, V66, P1987, DOI 10.7754/Clin.Lab.2020.200120
   Tvrzicka E, 2011, BIOMED PAP, V155, P117, DOI 10.5507/bp.2011.038
   van Smeden J, 2016, CURR PROBL DERMATOL, V49, P8, DOI 10.1159/000441540
   Verma D, 2021, CUREUS J MED SCIENCE, V13, DOI 10.7759/cureus.14029
   Vincenzi B, 2014, SCHIZOPHR RES, V159, P395, DOI 10.1016/j.schres.2014.08.021
   Wysokinski A, 2015, DIABETES METAB SYND, V9, P168, DOI 10.1016/j.dsx.2015.04.004
   Yang RL, 2008, J CLIN BIOCHEM NUTR, V43, P154, DOI 10.3164/jcbn.2008044
   Yang ST, 2016, CHEM PHYS LIPIDS, V199, P136, DOI 10.1016/j.chemphyslip.2016.05.003
   Yuii K, 2007, ANN NY ACAD SCI, V1113, P276, DOI 10.1196/annals.1391.013
   Zhou X, 2020, FRONT NEUROSCI-SWITZ, V14, DOI 10.3389/fnins.2020.00784
   Zhou X, 2017, SCHIZOPHRENIA BULL, V43, pS12
NR 51
TC 4
Z9 4
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0738-081X
EI 1879-1131
J9 CLIN DERMATOL
JI Clin. Dermatol.
PD JAN-FEB
PY 2023
VL 41
IS 1
BP 89
EP 94
DI 10.1016/j.clindermatol.2023.03.007
EA JUL 2023
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA M9JI0
UT WOS:001033298400001
PM 36878451
DA 2025-06-11
ER

PT J
AU Wu, YY
   Li, SS
   Han, D
   Zhang, M
   Zhao, J
   Liao, H
   Ma, Y
   Yan, CY
   Wang, J
AF Wu, Yunyi
   Li, Sangsang
   Han, Dan
   Zhang, Mei
   Zhao, Jie
   Liao, Hui
   Ma, Ying
   Yan, Chaoyang
   Wang, Jing
TI The Mediating Role of Depression in Association Between Total Sleep Time
   and Instrumental Activities of Daily Living in China
SO INTERNATIONAL JOURNAL OF PUBLIC HEALTH
LA English
DT Article
DE total sleep time; IADL disability; depression; gender difference; panel
   data
ID GENDER-DIFFERENCES; OLDER-ADULTS; FUNCTIONAL DISABILITY; COGNITIVE
   FUNCTION; METABOLIC SYNDROME; PHYSICAL FUNCTION; GLOBAL BURDEN;
   DURATION; SYMPTOMS; HEALTH
AB Objectives: This study aims to investigate the mediating role of depression and the moderating effect of gender in the relationship between total sleep time (TST) and instrumental activities of daily living (IADL) in middle-aged and elderly people (aged 45 or above).Methods: The data used in this study is from the China Health and Retirement Longitudinal Study (CHARLS), including a total of 10,460 respondents. Associations between TST, IADL, depression, and gender were analyzed using logistic regression and Karlson, Holm, and Breen (KHB) methods.Results: Short (OR = 1.42, 95% CI = 1.28-1.58 of <= 6 h) and long TST (OR = 1.16, 95% CI = 1.02-1.32 of 8-9 h; OR = 1.35, 95% CI = 1.19-1.54 of >9 h) were both associated with IADL. The mediation effect analyses observed that depression explained 64.80% of the total effect of short TST (<= 6 h) and IADL, but was insignificant in long TST (8-9 h and >9 h). Meanwhile, gender has moderating effects on the mediation effect model.Conclusion: The study suggests that health interventions that focused on the dimensions of TST and depression are crucial for preventing functional disability while accounting for gender differences.
C1 [Wu, Yunyi; Li, Sangsang; Han, Dan; Zhang, Mei; Zhao, Jie; Liao, Hui; Ma, Ying; Yan, Chaoyang; Wang, Jing] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Med & Hlth Management, Dept Hlth Management, Wuhan, Peoples R China.
   [Wang, Jing] Huazhong Univ Sci & Technol, Key Res Inst Humanities & Social Sci Hubei Prov, Wuhan, Peoples R China.
   [Wang, Jing] Huazhong Univ Sci & Technol, Inst Poverty Reduct & Dev, Wuhan, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology
RP Wang, J (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Med & Hlth Management, Dept Hlth Management, Wuhan, Peoples R China.; Wang, J (corresponding author), Huazhong Univ Sci & Technol, Key Res Inst Humanities & Social Sci Hubei Prov, Wuhan, Peoples R China.; Wang, J (corresponding author), Huazhong Univ Sci & Technol, Inst Poverty Reduct & Dev, Wuhan, Peoples R China.
EM jingwang@hust.edu.cn
RI Liao, Hui/IQU-4142-2023; Ding, Hu/KAM-6579-2024; Yan,
   Chaoyang/GXG-4324-2022
CR Arora T, 2011, DIABETES CARE, V34, P2317, DOI 10.2337/dc11-0647
   Burgard SA, 2013, AM SOCIOL REV, V78, P51, DOI 10.1177/0003122412472048
   Burgard SA, 2011, SOC FORCES, V89, P1189, DOI 10.1093/sf/89.4.1189
   Cole MG, 2003, AM J PSYCHIAT, V160, P1147, DOI 10.1176/appi.ajp.160.6.1147
   Cooper AB, 2008, CRIT CARE MED, V36, P2962, DOI 10.1097/CCM.0b013e318187268d
   Fang MW, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16050774
   Firth-Cozens J, 1998, BRIT J GEN PRACT, V48, P1647
   Freedman VA, 2002, JAMA-J AM MED ASSOC, V288, P3137, DOI 10.1001/jama.288.24.3137
   Friedman E, 2019, HEALTH PSYCHOL, V38, P791, DOI 10.1037/hea0000749
   Friedman EM, 2019, THER ADV CHRONIC DIS, V10, DOI 10.1177/2040622318806848
   Goldsmith DR, 2016, MOL PSYCHIATR, V21, P1696, DOI 10.1038/mp.2016.3
   Gong BY, 2021, MENOPAUSE, V28, P667, DOI 10.1097/GME.0000000000001773
   Grandner MA, 2007, SLEEP MED REV, V11, P341, DOI 10.1016/j.smrv.2007.03.010
   Hajek A, 2017, INT PSYCHOGERIATR, V29, P885, DOI 10.1017/S1041610216002507
   Hsiao C, 2007, TEST-SPAIN, V16, P1, DOI 10.1007/s11749-007-0046-x
   Irwin M, 1999, ARCH INTERN MED, V159, P1701, DOI 10.1001/archinte.159.15.1701
   Jing RZ, 2020, NAT SCI SLEEP, V12, P737, DOI 10.2147/NSS.S269992
   Johnston KJ, 2018, JAMA INTERN MED, V178, P1489, DOI 10.1001/jamainternmed.2018.4143
   Katon Wayne J, 2011, Dialogues Clin Neurosci, V13, P7
   KATZ S, 1963, JAMA-J AM MED ASSOC, V185, P914, DOI 10.1001/jama.1963.03060120024016
   Kohler U, 2011, STATA J, V11, P420, DOI 10.1177/1536867X1101100306
   Kong DX, 2019, J AM GERIATR SOC, V67, pS538, DOI 10.1111/jgs.15801
   LAWTON MP, 1969, GERONTOLOGIST, V9, P179, DOI 10.1093/geront/9.3_Part_1.179
   Li YJ, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-12182-0
   Lippman S, 2017, SLEEP MED, V40, P58, DOI 10.1016/j.sleep.2017.09.019
   Liu ML, 2021, ARCH GERONTOL GERIAT, V94, DOI 10.1016/j.archger.2021.104369
   Lucassen EA, 2012, ANN NY ACAD SCI, V1264, P110, DOI 10.1111/j.1749-6632.2012.06655.x
   Maume DJ, 2009, AM SOCIOL REV, V74, P989, DOI 10.1177/000312240907400607
   Mezick EJ, 2011, SLEEP MED REV, V15, P51, DOI 10.1016/j.smrv.2010.03.001
   Murray CJL, 1997, LANCET, V349, P1498, DOI 10.1016/S0140-6736(96)07492-2
   Murray CJL, 1996, SCIENCE, V274, P740, DOI 10.1126/science.274.5288.740
   Naseer M, 2016, EUR J CLIN NUTR, V70, P399, DOI 10.1038/ejcn.2015.196
   Nes RB, 2013, J AFFECT DISORDERS, V144, P51, DOI 10.1016/j.jad.2012.05.060
   Ning HT, 2022, J AFFECT DISORDERS, V296, P216, DOI 10.1016/j.jad.2021.09.061
   Novati A, 2008, SLEEP, V31, P1579, DOI 10.1093/sleep/31.11.1579
   Ohayon MM, 2005, SLEEP, V28, P981
   Okun ML, 2011, PSYCHOSOM MED, V73, P142, DOI 10.1097/PSY.0b013e3182020d08
   Parker G, 2010, INT REV PSYCHIATR, V22, P429, DOI 10.3109/09540261.2010.492391
   Paudel M, 2013, SLEEP, V36, P1033, DOI 10.5665/sleep.2804
   Peng SZ, 2021, J AFFECT DISORDERS, V295, P703, DOI 10.1016/j.jad.2021.08.072
   Perlman CA, 2006, BIPOLAR DISORD, V8, P271, DOI 10.1111/j.1399-5618.2006.00330.x
   Polo-Kantola P, 2016, MATURITAS, V94, P77, DOI 10.1016/j.maturitas.2016.09.002
   Schuch JJJ, 2014, J AFFECT DISORDERS, V156, P156, DOI 10.1016/j.jad.2013.12.011
   Shan ZL, 2015, DIABETES CARE, V38, P529, DOI 10.2337/dc14-2073
   Shandra CL, 2014, DISABIL HEALTH J, V7, P325, DOI 10.1016/j.dhjo.2014.02.002
   Song Y, 2015, J AM GERIATR SOC, V63, P1622, DOI 10.1111/jgs.13527
   Sonnenberg CM, 2000, ACTA PSYCHIAT SCAND, V101, P286, DOI 10.1034/j.1600-0447.2000.101004286.x
   Spira AP, 2012, J AM GERIATR SOC, V60, P1092, DOI 10.1111/j.1532-5415.2012.03968.x
   Sun YK, 2018, SLEEP MED, V52, P221, DOI 10.1016/j.sleep.2018.03.011
   Taylor WD, 2013, MOL PSYCHIATR, V18, P963, DOI 10.1038/mp.2013.20
   Thompson WW, 2012, AM J PUBLIC HEALTH, V102, P496, DOI 10.2105/AJPH.2011.300500
   Triolo F, 2020, MECH AGEING DEV, V192, DOI 10.1016/j.mad.2020.111383
   Tseng LA, 2012, MENOPAUSE, V19, P1186, DOI 10.1097/gme.0b013e3182565740
   Tsuang D, 2007, AM J PSYCHIAT, V164, P982, DOI 10.1176/appi.ajp.164.6.982
   van Mill JG, 2014, J CLIN PSYCHIAT, V75, P119, DOI 10.4088/JCP.12m08047
   World Health Organization, 2021, AG HLTH CHIN
   World Health Organization, 2021, PERSONS DISABILITIES
   World Health Organization, 2021, INT PAR COMM WHO SIG
   World Health Organization. World Health Organization, 2015, WHO CHIN COUNTR ASS
   Yokoyama E, 2010, SLEEP, V33, P1693, DOI 10.1093/sleep/33.12.1693
   Zhai L, 2015, DEPRESS ANXIETY, V32, P664, DOI 10.1002/da.22386
   Zhao YH, 2014, INT J EPIDEMIOL, V43, P61, DOI 10.1093/ije/dys203
   Zhong YQ, 2017, INT J EQUITY HEALTH, V16, DOI 10.1186/s12939-017-0662-3
NR 63
TC 7
Z9 7
U1 7
U2 47
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1661-8556
EI 1661-8564
J9 INT J PUBLIC HEALTH
JI Int. J. Public Health
PD APR 4
PY 2023
VL 68
AR 1605678
DI 10.3389/ijph.2023.1605678
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA D5UQ4
UT WOS:000969386200001
PM 37081904
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Abdelkarem, HM
   Fadda, LH
AF Abdelkarem, Hala M.
   Fadda, Lila H.
TI Flaxseed and quercetin improve anti-inflammatory cytokine level and
   insulin sensitivity in animal model of metabolic syndrome, the
   fructose-fed rats
SO ARABIAN JOURNAL OF CHEMISTRY
LA English
DT Article
DE Metabolic syndrome; Leptin; Adiponectin; High fructose diet; Insulin and
   diabetes
ID CORONARY-HEART-DISEASE; NECROSIS-FACTOR-ALPHA; OXIDATIVE STRESS;
   GENE-EXPRESSION; ADIPOSE-TISSUE; SECOISOLARICIRESINOL DIGLUCOSIDE;
   ADIPONECTIN EXPRESSION; FLAVONOID QUERCETIN; RISK-FACTORS; IN-VIVO
AB The purpose of this study is to assess the beneficial effect of quercetin, flaxseed and/or in combination as synergetic in an animal model of metabolic syndrome (MtS), high fructose (HF)-fed rats. Fifty male Sprague-Dawley rats, 3-month old and weighing between 110 and 120 g were randomly divided into 2 groups. Rats were given drinking water (-ve control rats) or 10% fructose in drinking water (HF; fructose-fed rats) with standard chow for 8 weeks. After 4 weeks of fructose feeding, HF-fed rats were further divided into matched 4 subgroups. Different groups of animals (n - 10, each group) were administered; 10% HF (5 mg/kg, +ve control), flaxseed (F; 50 mg/kg), quercetin (Q; 50 mg/kg), flaxseed + quercetin, (FQ; 25 mg/kg of each), respectively. All ingredients were given orally once daily and subsequent 4 weeks. Serum glucose, insulin, lipids profile, leptin, and adiponectin were estimated. After 4 weeks of feeding, a significant increase in blood glucose level was observed in HF fed rats compared to normal rats, but this increase was significantly decreased after administration of F, Q and FQ. The raised serum insulin level in HF fed rats was significantly decreased after administration of F and FQ groups. Significantly higher concentrations of triacylglycerols (TG), total cholesterol and low density lipoprotein cholesterol (LDL-C) were observed in HF fed rats and these increases were lower after administration of F, Q and FQ. There was a significant increase in serum high density lipoprotein cholesterol (HDL-C) in the FQ group. The increased serum leptin level was decreased significantly in F, Q and FQ groups. Whereas the reduction of serum adiponectin level in HF fed rats was increased in F, Q and FQ groups. These data suggested that protective effect of flaxseed and quercetin consumption as functional foods could reduce risk for people with decreased insulin sensitivity and increased oxidative stress, such as those with the metabolic syndrome or type 2 diabetes. (C) 2013 King Saud University. Production and hosting by Elsevier B.V.
C1 [Abdelkarem, Hala M.] Al Jouf Univ, Biochem Dept, Sci Coll, Jouf, Saudi Arabia.
   King Saud Univ, Pharmacol Dept, Pharm Coll, Riyadh, Saudi Arabia.
   Natl Res Ctr, Human Nutr Dept, Cairo, Egypt.
C3 Al Jouf University; King Saud University; Egyptian Knowledge Bank (EKB);
   National Research Centre (NRC)
RP Abdelkarem, HM (corresponding author), Al Jouf Univ, Biochem Dept, Sci Coll, Jouf, Saudi Arabia.
EM halaabdelkarem@yahoo.com
RI Abdelkarem, Hala/AAH-7001-2021
CR Absher PM, 1999, ATHEROSCLEROSIS, V143, P245, DOI 10.1016/S0021-9150(98)00295-0
   Absher PM, 1997, ATHEROSCLEROSIS, V131, P187, DOI 10.1016/S0021-9150(97)06104-2
   Albert CM, 2005, CIRCULATION, V112, P3232, DOI 10.1161/CIRCULATIONAHA.105.572008
   Ander BP, 2004, J NUTR, V134, P3250, DOI 10.1093/jn/134.12.3250
   Bloch-Damti A, 2005, ANTIOXID REDOX SIGN, V7, P1553, DOI 10.1089/ars.2005.7.1553
   Brooks NL, 2007, DIABETES OBES METAB, V9, P246, DOI 10.1111/j.1463-1326.2006.00596.x
   Busserolles J, 2003, J NUTR, V133, P1903, DOI 10.1093/jn/133.6.1903
   Busserolles J, 2002, BRIT J NUTR, V87, P337, DOI 10.1079/BJNBJN2002524
   Castilla P, 2006, AM J CLIN NUTR, V84, P252, DOI 10.1093/ajcn/84.1.252
   Chen K, 2008, DIABETES VASC DIS RE, V5, P96, DOI 10.3132/dvdr.2008.016
   Cohen SL, 2005, J NUTR BIOCHEM, V16, P368, DOI 10.1016/j.jnutbio.2005.01.008
   Comalada M, 2006, BIOCHEM PHARMACOL, V72, P1010, DOI 10.1016/j.bcp.2006.07.016
   Craig WJ, 1999, AM J CLIN NUTR, V70, p491S, DOI 10.1093/ajcn/70.3.491s
   CUNNANE SC, 1993, BRIT J NUTR, V69, P443, DOI 10.1079/BJN19930046
   Dinarello C A, 1998, Int Rev Immunol, V16, P457, DOI 10.3109/08830189809043005
   Duarte J, 2002, J HYPERTENS, V20, P1843, DOI 10.1097/00004872-200209000-00031
   Dupasquier CMC, 2007, AM J PHYSIOL-HEART C, V293, pH2394, DOI 10.1152/ajpheart.01104.2006
   Estruch R, 2006, ANN INTERN MED, V145, P1, DOI 10.7326/0003-4819-145-1-200607040-00004
   Felmlee MA, 2009, BRIT J NUTR, V102, P361, DOI 10.1017/S0007114508207488
   Fukumitsu S, 2008, BRIT J NUTR, V100, P669, DOI 10.1017/S0007114508911570
   Grattagliano I, 2008, J NUTR BIOCHEM, V19, P491, DOI 10.1016/j.jnutbio.2007.06.011
   Hall Iii C., 2006, FLAXSEED ADV FOOD NU, P1
   Halleux CM, 2001, BIOCHEM BIOPH RES CO, V288, P1102, DOI 10.1006/bbrc.2001.5904
   Haluzík M, 2004, PHYSIOL RES, V53, P123, DOI 10.33549/physiolres.930479
   HERTOG MGL, 1993, LANCET, V342, P1007, DOI 10.1016/0140-6736(93)92876-U
   Horiuchi M, 2011, HYPERTENSION, V57, P672, DOI 10.1161/HYPERTENSIONAHA.110.165845
   HOTAMISLIGIL GS, 1995, J CLIN INVEST, V95, P2409, DOI 10.1172/JCI117936
   Hu QH, 2009, AM J PHYSIOL-RENAL, V297, pF1080, DOI 10.1152/ajprenal.90767.2008
   Huypens P, 2007, MED HYPOTHESES, V68, P87, DOI 10.1016/j.mehy.2006.06.031
   Iacobellis G, 2005, CYTOKINE, V29, P251, DOI 10.1016/j.cyto.2004.11.002
   Ide T, 2000, BBA-MOL CELL BIOL L, V1485, P23, DOI 10.1016/S1388-1981(00)00026-3
   Ishizaka N, 2009, ATHEROSCLEROSIS, V204, P619, DOI 10.1016/j.atherosclerosis.2008.10.022
   Knekt P, 2002, AM J CLIN NUTR, V76, P560, DOI 10.1093/ajcn/76.3.560
   McCullough RS, 2011, LIPIDS, V46, P1043, DOI 10.1007/s11745-011-3619-0
   Middleton E, 2000, PHARMACOL REV, V52, P673
   Mink PJ, 2007, AM J CLIN NUTR, V85, P895, DOI 10.1093/ajcn/85.3.895
   Nair MP, 2006, CLIN VACCINE IMMUNOL, V13, P319, DOI 10.1128/CVI.13.3.319-328.2006
   Paolisso G, 1996, DIABETOLOGIA, V39, P357, DOI 10.1007/BF00418354
   Park SH, 2007, J AM COLL NUTR, V26, P321, DOI 10.1080/07315724.2007.10719618
   Prasad K, 2001, J LAB CLIN MED, V138, P32, DOI 10.1067/mlc.2001.115717
   Reungjui S, 2007, J AM SOC NEPHROL, V18, P2724, DOI 10.1681/ASN.2007040416
   Rivera L, 2008, OBESITY, V16, P2081, DOI 10.1038/oby.2008.315
   Steinberg HO, 1996, J CLIN INVEST, V97, P2601, DOI 10.1172/JCI118709
   Thresher JS, 2000, AM J PHYSIOL-REG I, V279, pR1334, DOI 10.1152/ajpregu.2000.279.4.R1334
   Veerapur VP, 2010, INDIAN J EXP BIOL, V48, P800
   Williamson G, 2005, AM J CLIN NUTR, V81, p243S, DOI 10.1093/ajcn/81.1.243S
NR 46
TC 8
Z9 9
U1 0
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1878-5352
EI 1878-5379
J9 ARAB J CHEM
JI Arab. J. Chem.
PD MAY
PY 2017
VL 10
SU 2
BP S3015
EP S3020
DI 10.1016/j.arabjc.2013.11.042
PG 6
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA FR2LG
UT WOS:000418897900086
OA gold
DA 2025-06-11
ER

PT J
AU Faulconbridge, LF
   Driscoll, CFB
   Hopkins, CM
   Benforado, BB
   Bishop-Gilyard, C
   Carvajal, R
   Berkowitz, RI
   DeRubeis, R
   Wadden, TA
AF Faulconbridge, Lucy F.
   Driscoll, Colleen F. B.
   Hopkins, Christina M.
   Benforado, Brooke Bailer
   Bishop-Gilyard, Chanelle
   Carvajal, Raymond
   Berkowitz, Robert I.
   DeRubeis, Robert
   Wadden, Thomas A.
TI Combined Treatment for Obesity and Depression: A Pilot Study
SO OBESITY
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; LIFE-STYLE INTERVENTION; WEIGHT-LOSS;
   CARDIOVASCULAR RISK; METABOLIC SYNDROME; COMORBID OBESITY;
   HEART-DISEASE; UNITED-STATES; WOMEN; INDIVIDUALS
AB ObjectiveObesity and depression frequently co-occur, and each increases risk for cardiovascular disease (CVD). This study tested whether a combined treatment, targeting obesity and depression simultaneously, would yield greater improvements in weight, mood, and CVD risk factors than treatments that targeted each disease individually.
   MethodsSeventy-six participants with obesity and major depression were randomly assigned to (1) behavioral weight control (BWC), (2) cognitive behavioral therapy for depression (CBT-D), or (3) BWC combined with CBT-D. Participants were provided 18 group treatment sessions over 20 weeks. Mood, weight, and CVD risk were assessed at baseline and weeks 8 and 20, with a follow-up visit at week 46.
   ResultsAt week 20, participants in combined treatment lost significantly (P<0.02) more weight (5.2%1.2%) than those assigned to CBT-D (0.8%+/- 1.3%) and comparable amounts as those in BWC (3.5%+/- 1.3%). Depression scores decreased significantly from baseline levels in each group, with no significant differences between groups. All three groups showed significant improvements in 10-year CVD risk, with no significant differences between groups. Groups did not differ significantly on any of these measures at week 46.
   ConclusionsBWC yielded short-term improvements in weight, mood, and CVD risk, comparable to a combined treatment that incorporated CBT-D. Results require replication with a larger sample size.
C1 [Faulconbridge, Lucy F.; Driscoll, Colleen F. B.; Hopkins, Christina M.; Benforado, Brooke Bailer; Bishop-Gilyard, Chanelle; Carvajal, Raymond; Berkowitz, Robert I.; DeRubeis, Robert; Wadden, Thomas A.] Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA.
   [Berkowitz, Robert I.] Childrens Hosp Philadelphia, Dept Psychiat, Philadelphia, PA 19104 USA.
   [DeRubeis, Robert] Univ Penn, Dept Psychol, 3815 Walnut St, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; University of Pennsylvania; Pennsylvania
   Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania
RP Faulconbridge, LF (corresponding author), Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA.
EM lucyhf@pennmedicine.upenn.edu
RI Driscoll, Colleen/KXR-7384-2024; DeRubeis, Robert/A-1049-2007; Cobden,
   David/AGL-5940-2022
OI Hopkins, Christina/0000-0003-4660-6641; Wadden,
   Thomas/0000-0002-0438-4609
FU Mentored Patient-Oriented Research Career Development Award (K23) from
   National Heart, Blood, and Lung Institute [K23-HL109235]
FX This research was supported by a Mentored Patient-Oriented Research
   Career Development Award (K23) to LFF from the National Heart, Blood,
   and Lung Institute (K23-HL109235).
CR ANDA R, 1993, EPIDEMIOLOGY, V4, P285, DOI 10.1097/00001648-199307000-00003
   [Anonymous], NIH PUBLICATION
   [Anonymous], COGNITIVE BEHAV THER
   Barth J, 2004, PSYCHOSOM MED, V66, P802, DOI 10.1097/01.psy.0000146332.53619.b2
   Beck A.T., 1979, COGNITIVE THERAPY DE
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   BECK AT, 1974, J CONSULT CLIN PSYCH, V42, P861, DOI 10.1037/h0037562
   Brinkworth GD, 2009, ARCH INTERN MED, V169, P1873, DOI 10.1001/archinternmed.2009.329
   Brownell KD., 2004, The LEARN Program for Weight Management, V10th
   Cuijpers P, 2010, CLIN PSYCHOL REV, V30, P51, DOI 10.1016/j.cpr.2009.09.003
   Espeland M, 2007, DIABETES CARE, V30, P1374
   Fabricatore AN, 2009, BEHAV RES THER, V47, P685, DOI 10.1016/j.brat.2009.05.004
   Faulconbridge LF, 2012, OBESITY, V20, P783, DOI 10.1038/oby.2011.315
   Faulconbridge LF, 2009, OBESITY, V17, P1009, DOI 10.1038/oby.2008.647
   Finer N, 2000, INT J OBESITY, V24, P306, DOI 10.1038/sj.ijo.0801128
   FRANK E, 1991, ARCH GEN PSYCHIAT, V48, P851, DOI 10.1001/archpsyc.1991.01810330075011
   Goff DC Jr, 2014, J AM COLL CARDIOL, V63, P2935, DOI 10.1016/j.jacc.2013.11.005
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Jeffery RW, 2003, INT J OBESITY, V27, P1584, DOI 10.1038/sj.ijo.0802473
   Jensen MD, 2014, OBESITY, V22, pS5, DOI 10.1002/oby.20821
   Keller MB, 1998, BIOL PSYCHIAT, V44, P348, DOI 10.1016/S0006-3223(98)00110-3
   Linde JA, 2011, ANN BEHAV MED, V41, P119, DOI 10.1007/s12160-010-9232-2
   Orchard TJ, 2005, ANN INTERN MED, V142, P611, DOI 10.7326/0003-4819-142-8-200504190-00009
   Pagoto S, 2013, INT J OBESITY, V37, P1427, DOI 10.1038/ijo.2013.25
   POLIVY J, 1992, INT J EAT DISORDER, V11, P261, DOI 10.1002/1098-108X(199204)11:3<261::AID-EAT2260110309>3.0.CO;2-F
   Pratt LA, 1996, CIRCULATION, V94, P3123, DOI 10.1161/01.CIR.94.12.3123
   Saydah S, 2014, OBESITY, V22, P1888, DOI 10.1002/oby.20761
   SPITZER RL, 1992, ARCH GEN PSYCHIAT, V49, P624
   Tate DF, 2001, JAMA-J AM MED ASSOC, V285, P1172, DOI 10.1001/jama.285.9.1172
   Tsai AG, 2008, OBESITY, V16, P59, DOI 10.1038/oby.2007.8
   Wadden TA, 2004, AM J CLIN NUTR, V80, P560
   Wadden TA, 2005, NEW ENGL J MED, V353, P2111, DOI 10.1056/NEJMoa050156
   Wadden TA, 2012, CIRCULATION, V125, P1157, DOI 10.1161/CIRCULATIONAHA.111.039453
   Wassertheil-Smoller S, 2004, ARCH INTERN MED, V164, P289, DOI 10.1001/archinte.164.3.289
   Webb VL, 2017, GASTROENTEROLOGY, V152, P1752, DOI 10.1053/j.gastro.2017.01.045
   Whelton PK, 1998, JAMA-J AM MED ASSOC, V279, P839, DOI 10.1001/jama.279.11.839
   Whooley MA, 2008, JAMA-J AM MED ASSOC, V300, P2379, DOI 10.1001/jama.2008.711
   Wing R. R., 2002, Handbook of obesity treatment, P301
   Wing RR, 2011, DIABETES CARE, V34, P1481, DOI 10.2337/dc10-2415
NR 40
TC 34
Z9 35
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD JUL
PY 2018
VL 26
IS 7
BP 1144
EP 1152
DI 10.1002/oby.22209
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA GK2HV
UT WOS:000435949600009
PM 29932516
DA 2025-06-11
ER

PT J
AU Canan, F
   Yildirim, O
   Tosun, M
   Kayka, N
   Tuman, TC
   Alcelik, A
AF Canan, Fatih
   Yildirim, Osman
   Tosun, Mehmet
   Kayka, Nefise
   Tuman, Taha Can
   Alcelik, Aytekin
TI SERUM LEVELS OF OMENTIN ARE NOT ALTERED IN DRUG-NAIVE PATIENTS WITH
   MAJOR DEPRESSION: A PILOT STUDY
SO PSYCHIATRIA DANUBINA
LA English
DT Article
DE adipokines; major depression; omentin
ID METABOLIC SYNDROME; PLASMA-LEVELS; ADIPOKINES; LEPTIN; ASSOCIATION;
   ADIPONECTIN; RISK; ADULTS; INFLAMMATION; PREVALENCE
AB Background: Decreased plasma levels of omentin, a relatively novel adipokine, are shown to be associated with metabolic abnormalities and proinflammatory states. Although other adipokines such as leptin and adiponectin have been extensively investigated in patients with major depressive disorder (MDD), no studies have evaluated omentin levels in major depression. Therefore, this study sought to test the hypothesis that drug-naive patients with MDD would have lower serum omentin levels than a healthy control group similar in age, sex, and body mass index.
   Subjects and methods: Thirty patients with MDD (10 men) and 30 healthy control subjects (10 men) were studied. Plasma concentration of omentin, along with other biochemical parameters, was measured after a period of fasting. The severity of depression was determined by the Beck Depression Inventory.
   Results: No significant difference was found between patients with MDD (723.3 +/- 233.8 ng/ml) and healthy comparison subjects (670.7 +/- 351.8 ng/ml) in mean plasma concentrations of omentin (p>0.05). There was no significant correlation between plasma omentin levels and depression severity (r=-0.147; p>0.05).
   Conclusions: This is the first investigation of omentin levels in patients with MDD. The hypothesis that circulating omentin levels would be different in depressed patients than in healthy controls is not supported by our data.
C1 [Canan, Fatih] Akdeniz Univ Sch Med, Dept Psychiat, TR-07059 Antalya, Turkey.
   [Yildirim, Osman; Kayka, Nefise; Tuman, Taha Can] Abant Izzet Baysal Univ Sch Med, Dept Psychiat, Bolu, Turkey.
   [Tosun, Mehmet] Abant Izzet Baysal Univ Sch Med, Dept Med Biochem, Bolu, Turkey.
   [Alcelik, Aytekin] Abant Izzet Baysal Univ Sch Med, Dept Internal Med, Bolu, Turkey.
C3 Akdeniz University; Abant Izzet Baysal University; Abant Izzet Baysal
   University; Abant Izzet Baysal University
RP Canan, F (corresponding author), Akdeniz Univ Sch Med, Dept Psychiat, TR-07059 Antalya, Turkey.
EM faithcanan@gmail.com
RI Canan, Fatih/C-1622-2016; TUMAN, TAHA/AAZ-5054-2020; Alcelik,
   Aytekin/B-4621-2015
OI Alcelik, Aytekin/0000-0002-3156-1076
CR Ahima RS, 2008, MOL ENDOCRINOL, V22, P1023, DOI 10.1210/me.2007-0529
   Ali S, 2006, DIABETIC MED, V23, P1165, DOI 10.1111/j.1464-5491.2006.01943.x
   Antonijevic IA, 1998, J PSYCHIAT RES, V32, P403, DOI 10.1016/S0022-3956(98)00032-6
   Ata SM, 2010, J WOMENS HEALTH, V19, P139, DOI 10.1089/jwh.2009.1472
   Barth J, 2004, PSYCHOSOM MED, V66, P802, DOI 10.1097/01.psy.0000146332.53619.b2
   Batista CMDS, 2007, DIABETES, V56, P1655, DOI 10.2337/db06-1506
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   Bonnet F, 2005, ATHEROSCLEROSIS, V178, P339, DOI 10.1016/j.atherosclerosis.2004.08.035
   Canan F, 2012, J PSYCHIATR RES, V46, P298, DOI 10.1016/j.jpsychires.2011.11.016
   Deuschle M, 1996, HORM METAB RES, V28, P714, DOI 10.1055/s-2007-979885
   Diniz BS, 2012, J PSYCHIATR RES, V46, P1081, DOI 10.1016/j.jpsychires.2012.04.028
   Dyck DJ, 2006, ACTA PHYSIOL, V186, P5, DOI 10.1111/j.1748-1716.2005.01502.x
   Egede LE, 2004, DIABETES CARE, V27, P421, DOI 10.2337/diacare.27.2.421
   First M.B., 2016, Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version
   Gecici O, 2005, PSYCHIAT CLIN NEUROS, V59, P736, DOI 10.1111/j.1440-1819.2005.01445.x
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Heuser I, 1998, PHARMACOPSYCHIATRY, V31, P10, DOI 10.1055/s-2007-979288
   Hisli N., 1989, J. Psychol
   Ishitobi Y, 2012, NEUROPSYCHOBIOLOGY, V66, P185, DOI 10.1159/000339948
   Kahl KG, 2012, EUR ARCH PSY CLIN N, V262, P313, DOI 10.1007/s00406-011-0277-4
   Kessler RC, 2003, JAMA-J AM MED ASSOC, V289, P3095, DOI 10.1001/jama.289.23.3095
   Kluge M, 2009, NEUROPSYCHOBIOLOGY, V59, P199, DOI 10.1159/000223731
   Lago F, 2009, TRENDS BIOCHEM SCI, V34, P500, DOI 10.1016/j.tibs.2009.06.008
   Laughlin GA, 2006, CLIN ENDOCRINOL, V65, P506, DOI 10.1111/j.1365-2265.2006.02624.x
   Leo R, 2006, NEUROSCI LETT, V407, P211, DOI 10.1016/j.neulet.2006.08.043
   Lu XY, 2007, CURR OPIN PHARMACOL, V7, P648, DOI 10.1016/j.coph.2007.10.010
   Lutter Michael, 2009, F1000 Biol Rep, V1, P63, DOI 10.3410/B1-63
   Maes M, 2011, PROG NEURO-PSYCHOPH, V35, P676, DOI 10.1016/j.pnpbp.2010.05.004
   Moreno-Navarrete JM, 2011, OBESITY, V19, P1552, DOI 10.1038/oby.2010.351
   Moosa MYH, 2003, J CLIN PSYCHOPHARM, V23, P549, DOI 10.1097/01.jcp.0000095341.32154.8f
   Ouchi N, 2011, NAT REV IMMUNOL, V11, P85, DOI 10.1038/nri2921
   Pan A, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001392
   Shibata R, 2012, DIABETOL METAB SYNDR, V4, DOI 10.1186/1758-5996-4-37
   Tan BK, 2010, TRENDS CARDIOVAS MED, V20, P143, DOI 10.1016/j.tcm.2010.12.002
   Taylor VH, 2010, J OBES, V2010, DOI 10.1155/2010/748048
   Weber-Hamann B, 2007, J PSYCHIATR RES, V41, P344, DOI 10.1016/j.jpsychires.2006.01.002
   Wulsin LR, 2003, PSYCHOSOM MED, V65, P201, DOI 10.1097/01.PSY.0000058371.50240.E3
   Yiannikouris F, 2010, CURR OPIN NEPHROL HY, V19, P195, DOI 10.1097/MNH.0b013e3283366cd0
   Zeman M, 2009, NEUROENDOCRINOL LETT, V30, P387
NR 39
TC 5
Z9 8
U1 0
U2 4
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PY 2014
VL 26
IS 1
BP 34
EP 38
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AK7UE
UT WOS:000338632400005
PM 24608150
DA 2025-06-11
ER

PT J
AU Sestito, A
   Maccallini, A
   Sgueglia, GA
   Infusino, F
   Larosa, C
   Aurigemma, C
   Crea, F
   Lanza, GA
AF Sestito, A
   Maccallini, A
   Sgueglia, GA
   Infusino, F
   Larosa, C
   Aurigemma, C
   Crea, F
   Lanza, GA
TI Platelet reactivity in response to mental stress in syndrome X and in
   stable or unstable coronary artery disease
SO THROMBOSIS RESEARCH
LA English
DT Article
DE platelet reactivity; mental stress test; syndrome X; stable angina;
   unstable angina
ID CARDIAC SYNDROME-X; MYOCARDIAL-ISCHEMIA; STRENUOUS EXERCISE; MODERATE
   EXERCISE; ANGINA-PECTORIS; AGGREGABILITY; ACTIVATION; AGGREGATION;
   VASOMOTION; FLOW
AB Introduction: Previous studies showed differences in reactivity in response to exercise in patients with syndrome X (SX) and those with obstructive coronary artery disease (CAD). In this study, we investigated whether similar differences could be detectable in response to a mental stressful stimulus.
   Materials and methods: We studied 30 SX patients (60 +/- 8 years, 8 men), 20 patients with stable angina and angiographically documented CAD (SA, 66 +/- 8 years, 14 men), and 11 patients with unstable angina (UA, 67 +/- 8 years, 6 men). A control group of 22 healthy controls (50 +/- 7 years, 5 men) was also studied. All subjects underwent a mathematical mental stress test (MST) consisting of rapid consecutive subtractions of number 7 for a period of 5 min. A venous blood sample was collected at baseline and immediately after MST Platelet reactivity was measured on flowing blood as time necessary to occlude a ring coated with collagen-adenosine diphosphate (ADP; closure time, CT), using the platelet function analyzer (PFA-100) system.
   Results: At rest, CT was lower in UA patients (87 +/- 19 s) compared to controls (109 +/- 24 s, p=0.02) and SA patients (105 +/- 37 s, p=0.055), and also tended to be lower in SX patients (96 +/- 18 s) compared to controls (p=0.07). The CT response to MST differed significantly among groups (p=0.0009). At peak MST, CT did not change in controls (110 +/- 27 s, p=0.88), whereas it decreased in SA patients (96 +/- 29 s, p=0.003) and tended to decrease in UA patients (82 +/- 15 s, p=0.25). In contrast, a significant increase in CT with MST was shown in SX patients (103 +/- 21 s, p=0.007).
   Conclusions Platelet reactivity is increased by MST in patients with CAD, whereas it paradoxically decreases in SX patients, which may constitute a protective effect against stress-induced events in these patients. (c) 2004 Elsevier Ltd. All rights reserved.
C1 Univ Cattolica S Cuore, Ist Cardiol, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Univ Cattolica S Cuore, Ist Cardiol, Lgo A Gemelli 8, I-00168 Rome, Italy.
EM g.a.lanza@inwind.it
RI Crea, Filippo/AAC-9754-2022; Larosa, Claudio/AAW-4457-2020; Aurigemma,
   Cristina/J-9958-2018; Lanza, Gaetano/AAC-2660-2019; Sgueglia,
   Gregory/A-9701-2019; Infusino, Fabio/JEF-6750-2023; BURZOTTA,
   FRANCESCO/K-1004-2018
OI Sgueglia, Gregory/0000-0001-9680-7412; Aurigemma,
   Cristina/0000-0001-6391-422X; Infusino, Fabio/0000-0001-9287-5936;
   BURZOTTA, FRANCESCO/0000-0002-6569-9401
CR Andreotti F, 2001, AM J CARDIOL, V87, P16, DOI 10.1016/S0002-9149(00)01265-0
   BRAUNWALD E, 1989, CIRCULATION, V80, P410, DOI 10.1161/01.CIR.80.2.410
   Buffon A, 2000, AM J PHYSIOL-HEART C, V279, pH2627, DOI 10.1152/ajpheart.2000.279.6.H2627
   Cadroy Y, 2002, J APPL PHYSIOL, V93, P829, DOI 10.1152/japplphysiol.00206.2002
   EGASHIRA K, 1993, NEW ENGL J MED, V328, P1659, DOI 10.1056/NEJM199306103282302
   FUSTER V, 1992, NEW ENGL J MED, V326, P310
   Gaspardone A, 1998, J AM COLL CARDIOL, V32, P2031, DOI 10.1016/S0735-1097(98)00470-7
   GRIGNANI G, 1992, HAEMOSTASIS, V22, P138
   KESTIN AS, 1993, CIRCULATION, V88, P1502, DOI 10.1161/01.CIR.88.4.1502
   KITAKAZE M, 1991, CIRC RES, V69, P1402, DOI 10.1161/01.RES.69.5.1402
   Kop WJ, 2001, J AM COLL CARDIOL, V37, P1359, DOI 10.1016/S0735-1097(01)01136-6
   Lanza GA, 2003, CIRCULATION, V107, P1378, DOI 10.1161/01.CIR.0000055317.72067.23
   Lanza GA, 1997, CIRCULATION, V96, P821
   Lanza GA, 2001, EUR HEART J, V22, P1924, DOI 10.1053/euhj.2001.2624
   LARSSON PT, 1989, CLIN SCI, V76, P369, DOI 10.1042/cs0760369
   LEVINE SP, 1985, CIRCULATION, V71, P1129, DOI 10.1161/01.CIR.71.6.1129
   Lombardo A, 2004, CIRCULATION, V109, P3158, DOI 10.1161/01.CIR.0000130786.28008.56
   MALKOFF SB, 1993, PSYCHOSOM MED, V55, P477, DOI 10.1097/00006842-199311000-00001
   MEHTA J, 1982, AM HEART J, V103, P49, DOI 10.1016/0002-8703(82)90528-2
   Minamino T, 1998, J CLIN INVEST, V101, P1643, DOI 10.1172/JCI635
   Rioufol G, 2002, CIRCULATION, V106, P804, DOI 10.1161/01.CIR.0000025609.13806.31
   ROZANSKI A, 1988, NEW ENGL J MED, V318, P1005, DOI 10.1056/NEJM198804213181601
   Schöder H, 2000, J NUCL MED, V41, P11
   Sestito A, 1999, Cardiologia, V44, P661
   SPECCHIA G, 1984, AM HEART J, V108, P56, DOI 10.1016/0002-8703(84)90544-1
   STREPTOE A, 2003, ATHEROSCLEROSIS, V168, P57
   Strike PC, 2004, PSYCHOSOM MED, V66, P492, DOI 10.1097/01.psy.0000130492.03488.e7
   Wallen NH, 1997, EUR HEART J, V18, P807
   WANG JS, 1994, CIRCULATION, V90, P2877, DOI 10.1161/01.CIR.90.6.2877
   WINTHER K, 1990, EUR HEART J, V11, P819
   YEUNG AC, 1991, NEW ENGL J MED, V325, P1551, DOI 10.1056/NEJM199111283252205
NR 31
TC 16
Z9 19
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0049-3848
J9 THROMB RES
JI Thromb. Res.
PY 2005
VL 116
IS 1
BP 25
EP 31
DI 10.1016/j.thromres.2004.10.002
PG 7
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 927DZ
UT WOS:000229173900003
PM 15850605
DA 2025-06-11
ER

PT J
AU Han, S
   Liang, CP
   DeVries-Seimon, T
   Ranalletta, M
   Welch, CL
   Collins-Fletcher, K
   Accili, D
   Tabas, I
   Tall, AR
AF Han, S
   Liang, CP
   DeVries-Seimon, T
   Ranalletta, M
   Welch, CL
   Collins-Fletcher, K
   Accili, D
   Tabas, I
   Tall, AR
TI Macrophage insulin receptor deficiency increases ER stress-induced
   apoptosis and necrotic core formation in advanced atherosclerotic
   lesions
SO CELL METABOLISM
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; CELL-DEATH; SCAVENGER RECEPTOR; SIGNALING
   PATHWAY; OXIDATIVE STRESS; GROWTH-FACTOR; ACTIVATION; CHOLESTEROL; MICE;
   RESISTANCE
AB Insulin resistance in diabetes and metabolic syndrome is thought to increase susceptibility to atherosclerotic cardiovascular disease, but the underlying mechanisms are poorly understood. To evaluate the possibility that decreased insulin signaling in macrophage foam cells might worsen atherosclerosis, Ldlr(-/-) mice were transplanted with insulin receptor Insr(+/+) or Insr(-/-) bone marrow. Western diet-fed Insr(-/-) recipients developed larger, more complex lesions with increased necrotic cores and increased numbers of apoptotic cells. Insr(-/-) macrophages showed diminished Akt phosphorylation and an augmented ER stress response, leading to induction of scavenger receptor A and increased apoptosis when challenged with cholesterol loading or nutrient deprivation. These studies suggest that defective insulin signaling and reduced Akt activity impair the ability of macrophages to deal with ER stress-induced apoptosis within atherosclerotic plaques.
C1 Columbia Univ, Dept Med Anat & Cell Biol, New York, NY 10032 USA.
   Columbia Univ, Dept Physiol & Cellular Biophys, New York, NY 10032 USA.
C3 Columbia University; Columbia University
RP Columbia Univ, Dept Med Anat & Cell Biol, New York, NY 10032 USA.
EM sh2068@columbia.edu; c1534@columbia.edu
RI Tall, Alan/AAT-8528-2021
OI Seimon, Tracie/0000-0003-3658-1364; Tabas, Ira/0000-0003-3429-1515
CR Accili D, 2004, CELL, V117, P421, DOI 10.1016/S0092-8674(04)00452-0
   Amaravadi R, 2005, J CLIN INVEST, V115, P2618, DOI 10.1172/JCI26273
   BALL RY, 1995, ATHEROSCLEROSIS, V114, P45, DOI 10.1016/0021-9150(94)05463-S
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Burke AP, 2004, ARTERIOSCL THROM VAS, V24, P1266, DOI 10.1161/01.ATV.0000131783.74034.97
   Chakravarthy MV, 2000, J BIOL CHEM, V275, P35942, DOI 10.1074/jbc.M005832200
   DeVries-Seimon T, 2005, J CELL BIOL, V171, P61, DOI 10.1083/jcb.200502078
   Du KY, 2003, SCIENCE, V300, P1574, DOI 10.1126/science.1079817
   Engel S, 2003, NEW ENGL J MED, V348, P2294
   Feng B, 2003, NAT CELL BIOL, V5, P781, DOI 10.1038/ncb1035
   Ginsberg HN, 2000, J CLIN INVEST, V106, P453, DOI 10.1172/JCI10762
   Glass CK, 2001, CELL, V104, P503, DOI 10.1016/S0092-8674(01)00238-0
   Greer EL, 2005, ONCOGENE, V24, P7410, DOI 10.1038/sj.onc.1209086
   Hansson GK, 2005, NEW ENGL J MED, V352, P1685, DOI 10.1056/NEJMra043430
   Hu P, 2004, J BIOL CHEM, V279, P49420, DOI 10.1074/jbc.M407700200
   Joseph SB, 2004, CELL, V119, P299, DOI 10.1016/j.cell.2004.09.032
   Kadowaki H, 2004, J CHEM NEUROANAT, V28, P93, DOI 10.1016/j.jchemneu.2004.05.004
   Kamata H, 2005, CELL, V120, P649, DOI 10.1016/j.cell.2004.12.041
   Kaneto H, 2005, J MOL MED, V83, P429, DOI 10.1007/s00109-005-0640-x
   Liang CP, 2004, J CLIN INVEST, V113, P764, DOI [10.1172/JCI200419528, 10.1172/JCI19528]
   Liang SH, 2006, BIOCHEM J, V393, P201, DOI 10.1042/BJ20050374
   Libby P, 2002, NATURE, V420, P868, DOI 10.1161/ATVBAHA.108.179705
   Liu J, 2005, ARTERIOSCL THROM VAS, V25, P174, DOI 10.1161/01.ATV.0000148548.47755.22
   Madrid LV, 2001, J BIOL CHEM, V276, P18934, DOI 10.1074/jbc.M101103200
   Maeda H, 2004, TRANSPL P, V36, P1163, DOI 10.1016/j.transproceed.2004.04.018
   Moore KJ, 2005, J CLIN INVEST, V115, P2192, DOI 10.1172/JCI24061
   Nakae J, 2003, DEV CELL, V4, P119, DOI 10.1016/S1534-5807(02)00401-X
   Ohoka N, 2005, EMBO J, V24, P1243, DOI 10.1038/sj.emboj.7600596
   Okamoto H, 2004, J CLIN INVEST, V114, P214, DOI 10.1172/JCI200421645
   Osaki M, 2004, APOPTOSIS, V9, P667, DOI 10.1023/B:APPT.0000045801.15585.dd
   Oyadomari S, 2004, CELL DEATH DIFFER, V11, P381, DOI 10.1038/sj.cdd.4401373
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Panini SR, 2001, CURR OPIN LIPIDOL, V12, P529, DOI 10.1097/00041433-200110000-00008
   Park HR, 2004, JNCI-J NATL CANCER I, V96, P1300, DOI 10.1093/jnci/djh243
   Pirro M, 2002, ATHEROSCLEROSIS, V160, P377, DOI 10.1016/S0021-9150(01)00588-3
   Reaven GM, 2002, DIABETES OBES METAB, V4, pS13, DOI 10.1046/j.1462-8902.2001.00037.x
   Salvayre R, 2002, BBA-MOL CELL BIOL L, V1585, P213, DOI 10.1016/S1388-1981(02)00343-8
   Steinberg HO, 2002, DIABETOLOGIA, V45, P623, DOI 10.1007/s00125-002-0800-2
   Tabas I, 2005, ARTERIOSCL THROM VAS, V25, P2255, DOI 10.1161/01.ATV.0000184783.04864.9f
   Tabas I, 2004, CELL DEATH DIFFER, V11, pS12, DOI 10.1038/sj.cdd.4401444
   Valledor AF, 2004, P NATL ACAD SCI USA, V101, P17813, DOI 10.1073/pnas.0407749101
   Vicent D, 2003, J CLIN INVEST, V111, P1373, DOI 10.1172/JCI200315211
   Vikramadithyan RK, 2005, J CLIN INVEST, V115, P2434, DOI 10.1172/JCI24819
   Welch CL, 2001, P NATL ACAD SCI USA, V98, P7946, DOI 10.1073/pnas.141239098
   Williams KJ, 1998, CURR OPIN LIPIDOL, V9, P471, DOI 10.1097/00041433-199810000-00012
   Yao PM, 2001, J BIOL CHEM, V276, P42468, DOI 10.1074/jbc.M101419200
NR 46
TC 234
Z9 262
U1 0
U2 11
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD APR
PY 2006
VL 3
IS 4
BP 257
EP 266
DI 10.1016/j.cmet.2006.02.008
PG 10
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 031GJ
UT WOS:000236692300006
PM 16581003
OA Bronze
DA 2025-06-11
ER

PT J
AU Roshanravan, N
   Shabestari, AN
   Alamdari, NM
   Ostadrahimi, A
   Separham, A
   Parvizi, R
   Jafarabadi, MA
   Ghodrat, M
   Akbarzadeh, M
   Naemi, M
   Ghazi, MKK
   Hadi, A
   Ghaffari, S
AF Roshanravan, Neda
   Shabestari, Alireza Namazi
   Alamdari, Naimeh Mesri
   Ostadrahimi, Alireza
   Separham, Ahmad
   Parvizi, Rezayat
   Jafarabadi, Mohammad Asghari
   Ghodrat, Mahshid
   Akbarzadeh, Moloud
   Naemi, Mohammad
   Ghazi, Mahdiyeh Khabbaz Koche
   Hadi, Amir
   Ghaffari, Samad
TI A novel inflammatory signaling pathway in patients with slow coronary
   flow: NF-κB/IL-1β/nitric oxide
SO CYTOKINE
LA English
DT Article
DE Slow coronary flow; Metabolic syndrome; Inflammation; Nitric oxide;
   NF-kappa B; IL-1 beta
ID TIMI FRAME COUNT; NF-KAPPA-B; NITRIC-OXIDE; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; ASSOCIATION; RATIO; THROMBOLYSIS; EXPRESSION;
   ARTERIES
AB Purpose: The slow coronary flow (SCF) was identified as delayed opacification of epicardial coronary arteries in the absence of stenotic lesion. Metabolic syndrome (MetS), oxidative stress, and inflammation may be possible known insulting factors for the pathogenesis of SCF. This investigation aimed to assess the relationship between some inflammatory markers, oxidative stress parameters and MetS components with SCF phenomenon.
   Methods: A total of 35 patients with SCF and 35 subjects with normal coronary flow (NCF) were included in the study. We assessed some inflammatory markers (IL-1 beta, IL-18, TNF-alpha, and NF-kappa B mRNA expression in peripheral blood mononuclear cells (PBMCs)). Moreover, blood samples of the participants were tested for total antioxidant capacity (TAC), glutathione peroxidase (GPX) and nitric oxide (NO) levels using enzyme-linked immunosorbent assay (ELISA). Diagnosis of MetS was based on the National Cholesterol Education Program's Adult Treatment Panel III report (ATPIII) criteria, 2005. Diagnostic criteria for coronary flow rates of all subjects were documented by thrombolysis in myocardial infarction (TIMI) frame count method.
   Results: SCF patients had significantly higher prevalence of MetS (46%, p = 0.048).We found that the level of TAC was significantly higher in the NCF group (p = 0.006). Furthermore, the NO concentration was significantly lower in SCF groups (p = 0.001). A significant incremental difference was detected in IL-1 beta (fold change 2.82 +/- 0.31, p < 0.05) and NF-kappa B (fold change 4.62 +/- 0.32, p < 0.05) mRNA expression in the SCF group when compared with its level in the NCF group. Furthermore, according to logistic regression analysis, there were significant associations between IL-1 beta, NF-kappa B expression levels and the incidence of SCF (p < 0.05).
   Conclusion: Based on the findings of this study, the pathogenesis of the SCF phenomenon may be closely associated with metabolic syndrome and inflammation. The NF-kappa B/IL-1 beta/nitric oxide & MetS signaling pathway might be considered as potential therapeutic targets in the management of SCF patients but further researches is required to guarantee these findings.
C1 [Roshanravan, Neda; Separham, Ahmad; Parvizi, Rezayat; Ghodrat, Mahshid; Akbarzadeh, Moloud; Ghaffari, Samad] Tabriz Univ Med Sci, Cardiovasc Res Ctr, Tabriz 5166615573, Iran.
   [Shabestari, Alireza Namazi] Univ Tehran Med Sci, Sch Med, Dept Geriatr Med, Tehran, Iran.
   [Alamdari, Naimeh Mesri] Iran Univ Med Sci, Sch Hlth, Students Res Comm, Tehran, Iran.
   [Ostadrahimi, Alireza; Naemi, Mohammad; Ghazi, Mahdiyeh Khabbaz Koche] Tabriz Univ Med Sci, Nutr Res Ctr, Tabriz, Iran.
   [Jafarabadi, Mohammad Asghari] Tabriz Univ Med Sci, Rd Traff Injury Res Ctr, Tabriz, Iran.
   [Akbarzadeh, Moloud] Tabriz Univ Med Sci, Stem Cell & Regenerat Med Inst, Tabriz, Iran.
   [Hadi, Amir] Isfahan Univ Med Sci, Food Secur Res Ctr, Sch Nutr & Food Sci, Dept Clin Nutr, Esfahan, Iran.
C3 Tabriz University of Medical Science; Tehran University of Medical
   Sciences; Iran University of Medical Sciences; Tabriz University of
   Medical Science; Tabriz University of Medical Science; Tabriz University
   of Medical Science; Isfahan University of Medical Sciences
RP Ghaffari, S (corresponding author), Tabriz Univ Med Sci, Cardiovasc Res Ctr, Tabriz 5166615573, Iran.
EM ghafaris@gmail.com
RI parvizi, rezayat/M-2889-2017; Hadi, Amir/AAK-4634-2020; akbarzadeh,
   moloud/HRE-3483-2023; Asghari Jafarabadi, Mohammmad/A-7478-2017;
   Separham, Ahmad/L-9475-2017
OI Asghari Jafarabadi, Mohammmad/0000-0003-3284-9749; Mesri Alamdari,
   Naimeh/0000-0003-2563-8193; Separham, Ahmad/0000-0001-7011-9507
FU Research Vice Chancellor, Tabriz University of Medical Sciences
FX This work was supported by the Research Vice Chancellor, Tabriz
   University of Medical Sciences.
CR Anfossi Giovanni, 2009, Archives of Physiology and Biochemistry, V115, P199, DOI 10.1080/13813450903136791
   [Anonymous], 2014, REV VASCULAR MED, DOI DOI 10.1016/J.RVM.2014.07.001
   Balletshofer BM, 2000, CIRCULATION, V101, P1780, DOI 10.1161/01.CIR.101.15.1780
   Beltrame JF, 2012, CIRC J, V76, P818, DOI 10.1253/circj.CJ-12-0205
   Binak E, 2006, INT J CARDIOL, V111, P142, DOI 10.1016/j.ijcard.2005.09.007
   Çamsari A, 2003, CIRC J, V67, P1022, DOI 10.1253/circj.67.1022
   Chaudhry MA, 2012, CARDIOL RES PRACT, V2012, DOI 10.1155/2012/383181
   Danaii S, 2020, IRAN J ALLERGY ASTHM, V19, P56, DOI 10.18502/ijaai.v19i1.2418
   Dogan M, 2015, CLIN APPL THROMB-HEM, V21, P251, DOI 10.1177/1076029613498814
   Doronzo G, 2004, EUR J CLIN INVEST, V34, P664, DOI 10.1111/j.1365-2362.2004.01412.x
   Enli Y, 2008, ADV THER, V25, P37, DOI 10.1007/s12325-008-0011-4
   Galkina E, 2009, ANNU REV IMMUNOL, V27, P165, DOI 10.1146/annurev.immunol.021908.132620
   Gary T, 2014, INT J CLIN PRACT, V68, P1483, DOI 10.1111/ijcp.12495
   Ghaffari S, 2017, PERFUSION-UK, V32, P13, DOI 10.1177/0267659116659918
   Gibson CM, 1996, CIRCULATION, V93, P879, DOI 10.1161/01.CIR.93.5.879
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Gupta S, 2008, J MOL BIOL, V375, P637, DOI 10.1016/j.jmb.2007.10.006
   Hawkins BM, 2012, CIRC J, V76, P936, DOI 10.1253/circj.CJ-11-0959
   Higashi Y, 1997, HYPERTENSION, V29, P280, DOI 10.1161/01.HYP.29.1.280
   Huang JY, 2018, J CLIN LAB ANAL, V32, DOI 10.1002/jcla.22232
   JOANNIDES R, 1995, CIRCULATION, V91, P1314, DOI 10.1161/01.CIR.91.5.1314
   Jones W Keith, 2003, Cardiovasc Toxicol, V3, P229, DOI 10.1385/CT:3:3:229
   Jones WK, 2005, CARDIOVASC TOXICOL, V5, P183, DOI 10.1385/CT:5:2:183
   Lee KS, 2014, BIOCHEM BIOPH RES CO, V448, P101, DOI 10.1016/j.bbrc.2014.04.079
   Liu T, 2017, SIGNAL TRANSDUCT TAR, V2, DOI 10.1038/sigtrans.2017.23
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   Mukhopadhyay S, 2018, INDIAN HEART J, V70, P405, DOI 10.1016/j.ihj.2017.09.001
   Murat SN, 2017, CLIN APPL THROMB-HEM, V23, P235, DOI 10.1177/1076029615627340
   Naruse M, 2000, Nihon Rinsho, V58, P344
   Ozcan T, 2008, CORONARY ARTERY DIS, V19, P591, DOI 10.1097/MCA.0b013e32831381c8
   Papadopoulou C, 2008, CYTOKINE, V43, P181, DOI 10.1016/j.cyto.2008.05.009
   Pekdemir H, 2004, ACTA CARDIOL, V59, P127, DOI 10.2143/AC.59.2.2005166
   Sezgin AT, 2003, CORONARY ARTERY DIS, V14, P155, DOI 10.1097/00019501-200304000-00008
   Sezgin N, 2005, INT HEART J, V46, P373, DOI 10.1536/ihj.46.373
   Sezgin N, 2017, INTERV MED APPL SCI, V9, P117, DOI 10.1556/1646.9.2017.17
   Su YC, 2014, CURR PHARM DESIGN, V20, P3514, DOI 10.2174/13816128113196660752
   TAMBE AA, 1972, AM HEART J, V84, P66, DOI 10.1016/0002-8703(72)90307-9
   Tripathi P, 2007, FEMS IMMUNOL MED MIC, V51, P443, DOI 10.1111/j.1574-695X.2007.00329.x
   Turhan H, 2004, AM HEART J, V148, P789, DOI 10.1016/j.ahj.2004.05.016
   Wallace JL, 2005, MEM I OSWALDO CRUZ, V100, P5, DOI 10.1590/S0074-02762005000900002
   Wang X, 2011, CARDIOVASC DIAGN THE, V1, P37, DOI 10.3978/j.issn.2223-3652.2011.10.01
   Yilmaz M, 2016, J INT MED RES, V44, P1443, DOI 10.1177/0300060516664637
   Zhu XG, 2019, CARDIOL RES PRACT, V2019, DOI 10.1155/2019/9168153
NR 43
TC 16
Z9 16
U1 0
U2 16
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-4666
EI 1096-0023
J9 CYTOKINE
JI Cytokine
PD JUL
PY 2021
VL 143
AR 155511
DI 10.1016/j.cyto.2021.155511
EA MAY 2021
PG 7
WC Biochemistry & Molecular Biology; Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Immunology
GA RZ5OG
UT WOS:000648645700006
PM 33839001
DA 2025-06-11
ER

PT J
AU McIntosh, RC
   Lobo, J
   Paparozzi, J
   Goodman, Z
   Kornfeld, S
   Nomi, J
AF McIntosh, Roger C.
   Lobo, Judith
   Paparozzi, Jeremy
   Goodman, Zach
   Kornfeld, Salome
   Nomi, Jason
TI Neutrophil to lymphocyte ratio is a transdiagnostic biomarker of
   depression and structural and functional brain alterations in older
   adults
SO JOURNAL OF NEUROIMMUNOLOGY
LA English
DT Article
DE Neutrophilia; Lymphocytopenia; Geriatric depression; Resting state
   functional connectivity; Medial frontal cortex; Perigenual anterior
   cingulate
ID C-REACTIVE PROTEIN; MEDIAL PREFRONTAL CORTEX; HUMAN CINGULATE CORTEX;
   INFLAMMATORY MARKERS; TNF-ALPHA; HYPOTHALAMIC INFLAMMATION;
   PLATELET-LYMPHOCYTE; METABOLIC SYNDROME; SICKNESS BEHAVIOR;
   GENE-EXPRESSION
AB The neutrophil to lymphocyte ratio (N:L) is an emergent transdiagnostic biomarker shown to predict peripheral inflammation as well as neuropsychiatric impairment. The afferent signaling of inflammation to the central nervous system has been implicated in the pathophysiology of sickness behavior and depression. Here, the N:L was compared to structural and functional limbic alterations found concomitant with depression within a geriatric cohort. Venous blood was collected for a complete blood count, and magnetic resonance imaging as well as phenotypic data were collected from the 66 community-dwelling older adults (aged 65-86 years). The N:L was regressed on gray matter volume and resting-state functional connectivity (rsFC) of the subgenual anterior cingulate (sgACC). Thresholded parameter estimates were extracted from structural and functional brain scans and bivariate associations tested with scores on the geriatric depression scale. Greater N:L predicted lower volume of hypothalamus and rsFC of sgACC with ventromedial prefrontal cortex. Both parameters were corre-lated (p < 0.05) with greater symptomology in those reporting moderate to severe levels of depression. These findings support the N:L as a transdiagnostic biomarker of limbic alteration underpinning mood disturbance in non-treated older adults.
C1 [McIntosh, Roger C.; Lobo, Judith; Paparozzi, Jeremy; Goodman, Zach; Kornfeld, Salome; Nomi, Jason] Univ Miami, Dept Psychol, Coral Gables, FL 33124 USA.
C3 University of Miami
RP McIntosh, RC (corresponding author), Univ Miami, Dept Psychol, Coral Gables, FL 33124 USA.
EM r.mcintosh@miami.edu
CR Adzic M, 2018, CURR NEUROPHARMACOL, V16, P176, DOI 10.2174/1570159X15666170828163048
   Alexopoulos GS, 2011, INT J GERIATR PSYCH, V26, P1109, DOI 10.1002/gps.2672
   Arabska J, 2018, PSYCHIAT RES, V263, P35, DOI 10.1016/j.psychres.2018.02.043
   Ashburner J., 2010, VBM TUTORIAL
   Aubé B, 2014, J IMMUNOL, V193, P2438, DOI 10.4049/jimmunol.1400401
   Beckmann M, 2009, J NEUROSCI, V29, P1175, DOI 10.1523/JNEUROSCI.3328-08.2009
   Berger P, 2002, CYTOKINE, V17, P171, DOI 10.1006/cyto.2001.0974
   Brinn A, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2020-036859
   Campbell S, 2004, AM J PSYCHIAT, V161, P598, DOI 10.1176/appi.ajp.161.4.598
   Cazettes F, 2011, BRAIN RES, V1373, P101, DOI 10.1016/j.brainres.2010.12.008
   Cernackova A, 2020, J CLIN NEUROSCI, V75, P5, DOI 10.1016/j.jocn.2020.03.005
   Chiba T, 2001, BRAIN RES, V888, P83, DOI 10.1016/S0006-8993(00)03013-4
   Clancy DM, 2017, FEBS J, V284, P1712, DOI 10.1111/febs.14075
   Corlier F, 2018, NEUROIMAGE, V172, P118, DOI 10.1016/j.neuroimage.2017.12.027
   Craig AD, 2009, NAT REV NEUROSCI, V10, P59, DOI 10.1038/nrn2555
   Critchley HD, 2003, BRAIN, V126, P2139, DOI 10.1093/brain/awg216
   Dalvi PS, 2017, INT J OBESITY, V41, P149, DOI 10.1038/ijo.2016.183
   Damoiseaux JS, 2006, P NATL ACAD SCI USA, V103, P13848, DOI 10.1073/pnas.0601417103
   Dantzer R, 2009, IMMUNOL ALLERGY CLIN, V29, P247, DOI 10.1016/j.iac.2009.02.002
   Demir I., 2020, FAMILY PRACTICE PALL, V5, P12
   Drew W, 2018, EXP GERONTOL, V105, P70, DOI 10.1016/j.exger.2017.12.020
   Eklund C, 2003, EUR CYTOKINE NETW, V14, P168
   Freedman LJ, 2000, J COMP NEUROL, V421, P172
   Fujita Y, 2021, CELL MOL LIFE SCI, V78, P3907, DOI 10.1007/s00018-021-03758-1
   Gabbott PLA, 2005, J COMP NEUROL, V492, P145, DOI 10.1002/cne.20738
   Galecki P, 2018, PROG NEURO-PSYCHOPH, V80, P291, DOI 10.1016/j.pnpbp.2017.03.016
   GALLO JJ, 1994, J GERONTOL, V49, pP251, DOI 10.1093/geronj/49.6.P251
   Haapakoski R, 2015, BRAIN BEHAV IMMUN, V49, P206, DOI 10.1016/j.bbi.2015.06.001
   Hamilton JP, 2015, BIOL PSYCHIAT, V78, P224, DOI 10.1016/j.biopsych.2015.02.020
   Harrison NA, 2009, BIOL PSYCHIAT, V66, P407, DOI 10.1016/j.biopsych.2009.03.015
   Hennessy E, 2017, BRAIN BEHAV IMMUN, V59, P233, DOI 10.1016/j.bbi.2016.09.011
   Hernández JCC, 2019, NAT NEUROSCI, V22, P413, DOI 10.1038/s41593-018-0329-4
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Hryhorczuk C, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00177
   Jiang JY, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0123399
   Jin S, 2016, SCI REP-UK, V6, DOI 10.1038/srep29424
   Joyce MKP, 2018, J NEUROSCI, V38, P1677, DOI 10.1523/JNEUROSCI.2363-17.2017
   Jung I.K., 1997, J KOREAN NEUROPSYCHI, P103
   Kaltenboeck Alexander, 2018, Brain Neurosci Adv, V2, p2398212818799269, DOI 10.1177/2398212818799269
   Kanemitsu Yoshio, 2000, Fukuoka Acta Medica, V91, P170
   Kayhan F, 2017, PSYCHIAT RES, V247, P332, DOI 10.1016/j.psychres.2016.11.016
   Kinser PA, 2013, NURS RES PRACT, V2013, DOI 10.1155/2013/469070
   Konsman JP, 2004, J COMP NEUROL, V472, P113, DOI 10.1002/cne.20052
   Kraynak TE, 2018, NEUROSCI BIOBEHAV R, V94, P76, DOI 10.1016/j.neubiorev.2018.07.013
   Krishnadas R, 2012, J NEUROL NEUROSUR PS, V83, P495, DOI 10.1136/jnnp-2011-301779
   Kushner I, 2001, CLEV CLIN J MED, V68, P535, DOI 10.3949/ccjm.68.6.535
   Ladenvall C, 2006, STROKE, V37, P2018, DOI 10.1161/01.STR.0000231872.86071.68
   Laumet G, 2018, NEUROPSYCHOPHARMACOL, V43, P2597, DOI 10.1038/s41386-018-0154-1
   Lekander M, 2016, BRAIN BEHAV IMMUN, V56, P34, DOI 10.1016/j.bbi.2015.12.018
   Lewisa CM, 2009, P NATL ACAD SCI USA, V106, P17558, DOI 10.1073/pnas.0902455106
   Liew PX, 2019, PHYSIOL REV, V99, P1223, DOI 10.1152/physrev.00012.2018
   Lindqvist D, 2015, NEUROSCI BIOBEHAV R, V55, P333, DOI 10.1016/j.neubiorev.2015.05.007
   Lu Y, 2013, RESP RES, V14, DOI 10.1186/1465-9921-14-53
   Lyness JM, 1997, ARCH INTERN MED, V157, P449, DOI 10.1001/archinte.157.4.449
   Marsland AL, 2017, BRAIN BEHAV IMMUN, V64, P208, DOI 10.1016/j.bbi.2017.01.011
   Martinac M, 2014, ACTA CLIN CROAT, V53, P55
   Mazza MG, 2019, GEN HOSP PSYCHIAT, V58, P7, DOI 10.1016/j.genhosppsych.2019.02.003
   Meisenzahl EM, 2001, AM J PSYCHIAT, V158, P1316, DOI 10.1176/appi.ajp.158.8.1316
   Michaud M, 2013, J AM MED DIR ASSOC, V14, P877, DOI 10.1016/j.jamda.2013.05.009
   Miller AH, 2016, NAT REV IMMUNOL, V16, P22, DOI 10.1038/nri.2015.5
   Mravec B, 2019, CELL MOL NEUROBIOL, V39, P11, DOI 10.1007/s10571-018-0631-4
   Nooner KB, 2012, FRONT NEUROSCI-SWITZ, V6, DOI 10.3389/fnins.2012.00152
   Nusslock R, 2016, BIOL PSYCHIAT, V80, P23, DOI 10.1016/j.biopsych.2015.05.017
   O'Connor MF, 2009, NEUROIMAGE, V47, P891, DOI 10.1016/j.neuroimage.2009.05.049
   Orimo Hajime, 2006, Nihon Ronen Igakkai Zasshi, V43, P27
   Persson N, 2014, NEUROIMAGE, V103, P334, DOI 10.1016/j.neuroimage.2014.09.042
   Pimentel GD, 2014, MOL CELL ENDOCRINOL, V397, P15, DOI 10.1016/j.mce.2014.06.005
   Power JD, 2012, NEUROIMAGE, V59, P2142, DOI 10.1016/j.neuroimage.2011.10.018
   Pue CA, 1996, J IMMUNOL, V156, P1594
   Puig J, 2015, J CLIN ENDOCR METAB, V100, pE276, DOI 10.1210/jc.2014-2682
   Puzianowska-Kuznicka M, 2016, IMMUN AGEING, V13, DOI 10.1186/s12979-016-0076-x
   Rainer TH, 1999, INJURY, V30, P179, DOI 10.1016/S0020-1383(98)00247-2
   Reitz C, 2007, STROKE, V38, P2356, DOI 10.1161/STROKEAHA.107.482661
   Satterthwaite TD, 2013, NEUROIMAGE, V64, P240, DOI 10.1016/j.neuroimage.2012.08.052
   Schachter J, 2018, BRAIN BEHAV IMMUN, V69, P1, DOI 10.1016/j.bbi.2017.08.026
   Schmaal L, 2017, MOL PSYCHIATR, V22, P900, DOI 10.1038/mp.2016.60
   Sirivelu MP, 2012, LIFE SCI, V90, P77, DOI 10.1016/j.lfs.2011.10.006
   Smith KJ, 2018, EXP GERONTOL, V102, P109, DOI 10.1016/j.exger.2017.12.005
   Soczynska JK, 2011, NEUROMOL MED, V13, P93, DOI 10.1007/s12017-010-8140-8
   Song H, 2021, AM J EMERG MED, V40, P133, DOI 10.1016/j.ajem.2020.01.044
   STRIETER RM, 1989, SCIENCE, V243, P1467, DOI 10.1126/science.2648570
   Sunbul EA, 2016, PSYCHIAT INVEST, V13, P121, DOI 10.4306/pi.2016.13.1.121
   Taki Y, 2013, HUM BRAIN MAPP, V34, P2418, DOI 10.1002/hbm.22073
   Torta DM, 2011, NEUROIMAGE, V56, P2157, DOI 10.1016/j.neuroimage.2011.03.066
   Uhl B, 2016, BLOOD, V128, P2327, DOI 10.1182/blood-2016-05-718999
   Valdearcos M, 2015, ANNU REV PHYSIOL, V77, P131, DOI 10.1146/annurev-physiol-021014-071656
   Valkanova V, 2013, J AFFECT DISORDERS, V150, P736, DOI 10.1016/j.jad.2013.06.004
   van den Biggelaar AHJ, 2007, EXP GERONTOL, V42, P693, DOI 10.1016/j.exger.2007.01.011
   Veer IM, 2012, PSYCHONEUROENDOCRINO, V37, P1039, DOI 10.1016/j.psyneuen.2011.12.001
   Vertes RP, 2004, SYNAPSE, V51, P32, DOI 10.1002/syn.10279
   Viscogliosi G, 2013, INT J GERIATR PSYCH, V28, P242, DOI 10.1002/gps.3817
   Wang Y, 2018, J PSYCHIATR RES, V105, P55, DOI 10.1016/j.jpsychires.2018.08.025
   Ward JR, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0015810
   Wu JH, 2015, NEUROIMAGE, V122, P158, DOI 10.1016/j.neuroimage.2015.08.016
   Yan CG, 2016, NEUROINFORMATICS, V14, P339, DOI 10.1007/s12021-016-9299-4
   Yan CG, 2010, FRONT SYST NEUROSCI, V4, DOI 10.3389/fnsys.2010.00013
   YESAVAGE JA, 1983, J PSYCHIATR RES, V17, P37, DOI 10.1016/0022-3956(82)90033-4
   Yu CS, 2011, NEUROIMAGE, V54, P2571, DOI 10.1016/j.neuroimage.2010.11.018
   Zahorec R, 2001, Bratisl Lek Listy, V102, P5
   Zhang HB, 2016, NEUROBIOL AGING, V37, P138, DOI 10.1016/j.neurobiolaging.2015.10.008
   Zhu JJ, 2017, SCHIZOPHRENIA BULL, V43, P1363, DOI 10.1093/schbul/sbx051
NR 101
TC 6
Z9 6
U1 0
U2 13
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-5728
EI 1872-8421
J9 J NEUROIMMUNOL
JI J. Neuroimmunol.
PD APR 15
PY 2022
VL 365
AR 577831
DI 10.1016/j.jneuroim.2022.577831
EA FEB 2022
PG 7
WC Immunology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology; Neurosciences & Neurology
GA 0V1RL
UT WOS:000788122500006
PM 35217366
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Walrabenstein, W
   van der Leeden, M
   Weijs, P
   van Middendorp, H
   Wagenaar, C
   van Dongen, JM
   Nieuwdorp, M
   de Jonge, CS
   van Boheemen, L
   van Schaardenburg, D
AF Walrabenstein, Wendy
   van der Leeden, Marike
   Weijs, Peter
   van Middendorp, Henriet
   Wagenaar, Carlijn
   van Dongen, Johanna Maria
   Nieuwdorp, Max
   de Jonge, Catharina Sophia
   van Boheemen, Laurette
   van Schaardenburg, Dirkjan
TI The effect of a multidisciplinary lifestyle program for patients with
   rheumatoid arthritis, an increased risk for rheumatoid arthritis or with
   metabolic syndrome-associated osteoarthritis: the "Plants for Joints"
   randomized controlled trial protocol
SO TRIALS
LA English
DT Article
ID DISEASE-ACTIVITY; KNEE OSTEOARTHRITIS; AMERICAN-COLLEGE; VEGETARIAN
   DIET; OBESE ADULTS; WEIGHT-LOSS; EXERCISE; CLASSIFICATION; INFLAMMATION;
   OVERWEIGHT
AB Low-grade inflammation and metabolic syndrome are seen in many chronic diseases, including rheumatoid arthritis (RA) and osteoarthritis (OA). Lifestyle interventions which combine different non-pharmacological therapies have shown synergizing effects in improving outcomes in patients with other chronic diseases or increased risk thereof, especially cardiovascular disease. For RA and metabolic syndrome-associated OA (MSOA), whole food plant-based diets (WFPDs) have shown promising results. A WFPD, however, had not yet been combined with other lifestyle interventions for RA and OA patients. In this protocol paper, we therefore present Plants for Joints, a multidisciplinary lifestyle program, based on a WFPD, exercise, and stress management. The objective is to study the effect of this program on disease activity in patients with RA (randomized controlled trial [RCT] 1), on a risk score for developing RA in patients with anti-citrullinated protein antibody (ACPA) positive arthralgia (RCT 2) and on pain, stiffness, and function in patients with MSOA (RCT 3), all in comparison with usual care. We designed three 16-week observer-blind RCTs with a waiting-list control group for patients with RA with low to moderate disease activity (2.6 <= Disease Activity Score [DAS28] <= 5.1, RCT 1, n = 80), for patients at risk for RA, defined by ACPA-positive arthralgia (RCT 2, n = 16) and for patients with metabolic syndrome and OA in the knee and/or hip (RCT 3, n = 80). After personal counseling on diet and exercise, participants join 10 group meetings with 6-12 other patients to receive theoretical and practical training on a WFPD, exercise, and stress management, while medication remains unchanged. The waiting-list control group receives usual care, while entering the program after the RCT. Primary outcomes are: difference in mean change between intervention and control groups within 16 weeks for the DAS28 in RA patients (RCT 1), the RA-risk score for ACPA positive arthralgia patients (RCT 2), and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) score for MSOA patients (RCT 3). Continued adherence to the lifestyle program is measured in a two-year observational extension study.
C1 [Walrabenstein, Wendy; van der Leeden, Marike; Wagenaar, Carlijn; van Boheemen, Laurette; van Schaardenburg, Dirkjan] Reade, Amsterdam Rheumatol & Immunol Ctr, Dr Jan van Breemenstr 2, NL-1056 AB Amsterdam, Netherlands.
   [Walrabenstein, Wendy; Wagenaar, Carlijn; van Boheemen, Laurette; van Schaardenburg, Dirkjan] Univ Amsterdam, Dept Rheumatol & Clin Immunol, Amsterdam UMC, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
   [van der Leeden, Marike] Vrije Univ Amsterdam, Dept Rehabil Med, Amsterdam UMC, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands.
   [van der Leeden, Marike; van Dongen, Johanna Maria] Amsterdam Publ Hlth Res Inst, De Boelelaan 1085, NL-1081 HV Amsterdam, Netherlands.
   [Weijs, Peter] Amsterdam Univ Appl Sci, Dokter Meurerlaan 8, NL-1067 SM Amsterdam, Netherlands.
   [Weijs, Peter] Vrije Univ Amsterdam, Amsterdam Univ, Dept Nutr & Dietet, Med Ctr, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands.
   [van Middendorp, Henriet] Leiden Univ, Inst Psychol, Hlth Med & Neuropsychol Unit, Leiden, Netherlands.
   [van Dongen, Johanna Maria] Vrije Univ Amsterdam, Fac Sci, Dept Hlth Sci, De Boelelaan 1085, NL-1081 HV Amsterdam, Netherlands.
   [Nieuwdorp, Max] Univ Amsterdam, Dept Internal Med, Amsterdam UMC, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
   [de Jonge, Catharina Sophia] Univ Amsterdam, Dept Radiol & Nucl Med, Amsterdam UMC, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
   [de Jonge, Catharina Sophia] Univ Amsterdam, Dept Gastroenterol Endocrinol Metab, Amsterdam UMC, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; University of Amsterdam; Vrije
   Universiteit Amsterdam; Vrije Universiteit Amsterdam; Leiden University;
   Leiden University - Excl LUMC; Vrije Universiteit Amsterdam; University
   of Amsterdam; University of Amsterdam; University of Amsterdam
RP Walrabenstein, W (corresponding author), Reade, Amsterdam Rheumatol & Immunol Ctr, Dr Jan van Breemenstr 2, NL-1056 AB Amsterdam, Netherlands.; Walrabenstein, W (corresponding author), Univ Amsterdam, Dept Rheumatol & Clin Immunol, Amsterdam UMC, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
EM w.walrabenstein@reade.nl
RI de Jonge, Catharina/AEM-1923-2022
OI Weijs, Peter/0000-0001-8281-0426; van Dongen, Johanna
   Maria/0000-0002-1606-8742; van der Leeden, Marike/0000-0001-6465-0983;
   Walrabenstein, Wendy/0000-0002-2428-2845; Wagenaar,
   Carlijn/0000-0002-0937-4450; de Jonge, Catharina/0000-0002-3921-0895
FU Reade (Amsterdam, the Netherlands); Reade Foundation (Amsterdam, the
   Netherlands); private ffoundation, Amsterdam, the Netherlands; W.M. de
   Hoop Stichting (private foundation, Bussum, the Netherlands); ZonMw
   [555003210]; ZonMw VICI grant 2020 [09150182010020]
FX The RCT is funded by Reade (Amsterdam, the Netherlands), Reade
   Foundation (Amsterdam, the Netherlands), Stichting Vermeer 14 (private
   ffoundation, Amsterdam, the Netherlands), and W.M. de Hoop Stichting
   (private foundation, Bussum, the Netherlands). The extension study and
   microbiome studies are funded by ZonMw no. 555003210. MN is supported by
   a ZonMw VICI grant 2020 no. 09150182010020 (see https://www.zonmw.
   nl/en/research-and-results/fundamental-research/programmas/programmedeta
   il/vici/t/awarded-projects/). The funders had no role in the design or
   execution of the study.
CR Abendroth A, 2010, FORSCH KOMPLEMENTMED, V17, P307, DOI 10.1159/000322313
   Aletaha D, 2009, ARTHRIT RHEUM-ARTHR, V61, P313, DOI 10.1002/art.24282
   Aletaha D, 2010, ANN RHEUM DIS, V69, P1580, DOI 10.1002/art.27584
   ALTMAN R, 1991, ARTHRITIS RHEUM, V34, P505, DOI 10.1002/art.1780340502
   ALTMAN R, 1986, ARTHRITIS RHEUM-US, V29, P1039, DOI 10.1002/art.1780290816
   Barnard ND, 2009, J AM DIET ASSOC, V109, P263, DOI 10.1016/j.jada.2008.10.049
   BELLAMY N, 1988, J RHEUMATOL, V15, P1833
   Chan AW, 2013, ANN INTERN MED, V158, P200, DOI 10.7326/0003-4819-158-3-201302050-00583
   Clemente JC, 2018, BMJ-BRIT MED J, V360, DOI 10.1136/bmj.j5145
   Clinton C, 2015, ARTHRITIS, DOI 10.1155/2015/708152
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Combe B, 2017, ANN RHEUM DIS, V76, P948, DOI 10.1136/annrheumdis-2016-210602
   Courties A, 2017, CURR OPIN RHEUMATOL, V29, P214, DOI 10.1097/BOR.0000000000000373
   Crowson CS, 2013, ARTHRIT CARE RES, V65, P71, DOI 10.1002/acr.21660
   de Brouwer SJM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027432
   de Hair MJH, 2013, ANN RHEUM DIS, V72, P1654, DOI 10.1136/annrheumdis-2012-202254
   de Jong Z, 2003, ARTHRITIS RHEUM, V48, P2415, DOI 10.1002/art.11216
   Di Giuseppe D, 2015, ARTHRITIS RES THER, V17, DOI 10.1186/s13075-015-0560-2
   Einarsson JT, 2019, RHEUMATOLOGY, V58, P227, DOI 10.1093/rheumatology/key054
   Evrengül H, 2004, RHEUMATOL INT, V24, P198, DOI 10.1007/s00296-003-0357-5
   Fernandes L, 2013, ANN RHEUM DIS, V72, P1125, DOI 10.1136/annrheumdis-2012-202745
   Ferwerda M, 2017, PAIN, V158, P868, DOI 10.1097/j.pain.0000000000000845
   Fransen J, 2006, CLIN EXP RHEUMATOL, V24, pS29
   Fransen M, 2015, BRIT J SPORT MED, V49, DOI 10.1136/bjsports-2015-095424
   Fransen M, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007912.pub2
   Furman D, 2019, NAT MED, V25, P1822, DOI 10.1038/s41591-019-0675-0
   Gezondheidsraad, BEW 2017
   Glyn-Jones S, 2015, LANCET, V386, P376, DOI 10.1016/S0140-6736(14)60802-3
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Hafström I, 2001, RHEUMATOLOGY, V40, P1175, DOI 10.1093/rheumatology/40.10.1175
   HAFSTROM I, 1988, ARTHRITIS RHEUM-US, V31, P585, DOI 10.1002/art.1780310502
   Hansildaar R, 2021, LANCET RHEUMATOL, V3, pE58, DOI 10.1016/S2665-9913(20)30221-6
   Hazlewood GS, 2016, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010227.pub2
   Holmqvist M, 2018, ANN RHEUM DIS, V77, P85, DOI 10.1136/annrheumdis-2017-212131
   Hu Y, 2017, ANN RHEUM DIS, V76, P1357, DOI 10.1136/annrheumdis-2016-210431
   Hurkmans E, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006853.pub2
   Jethwa H, 2017, RHEUMATOLOGY, V56, P1452, DOI 10.1093/rheumatology/kew374
   Kanters TA, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0187477
   KJELDSENKRAGH J, 1991, LANCET, V338, P899, DOI 10.1016/0140-6736(91)91770-U
   Koopman FA, 2016, EBIOMEDICINE, V6, P231, DOI 10.1016/j.ebiom.2016.02.029
   Lee AC, 2017, ARCH PHYS MED REHAB, V98, P2265, DOI 10.1016/j.apmr.2017.04.014
   Lee YC, 2016, ARTHRIT CARE RES, V68, P292, DOI 10.1002/acr.22683
   Melina V, 2016, J ACAD NUTR DIET, V116, P1970, DOI 10.1016/j.jand.2016.09.025
   Messier SP, 2004, ARTHRITIS RHEUM-US, V50, P1501, DOI 10.1002/art.20256
   Messier SP, 2013, JAMA-J AM MED ASSOC, V310, P1263, DOI 10.1001/jama.2013.277669
   Miller GD, 2006, OBESITY, V14, P1219, DOI 10.1038/oby.2006.139
   O'Donovan A, 2015, BIOL PSYCHIAT, V77, P365, DOI 10.1016/j.biopsych.2014.06.015
   Ocké M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13041135
   Ornish D, 1998, JAMA-J AM MED ASSOC, V280, P2001, DOI 10.1001/jama.280.23.2001
   Ornish D, 2013, LANCET ONCOL, V14, P1112, DOI 10.1016/S1470-2045(13)70366-8
   Piva SR, 2004, ARCH PHYS MED REHAB, V85, P284, DOI 10.1016/j.apmr.2003.05.001
   Pradhan EK, 2007, ARTHRIT RHEUM-ARTHR, V57, P1134, DOI 10.1002/art.23010
   Puenpatom RA, 2009, POSTGRAD MED, V121, P9, DOI 10.3810/pgm.2009.11.2073
   Roberts HC, 2011, AGE AGEING, V40, P423, DOI 10.1093/ageing/afr051
   Roorda LD, 2004, ANN RHEUM DIS, V63, P36, DOI 10.1136/ard.2002.001784
   Sattar N, 2003, CIRCULATION, V108, P2957, DOI 10.1161/01.CIR.0000099844.31524.05
   Sekar S, 2017, SCI REP-UK, V7, DOI 10.1038/srep46457
   SKOLDSTAM L, 1979, SCAND J RHEUMATOL, V8, P249, DOI 10.3109/03009747909114631
   Sköldstam L, 2003, ANN RHEUM DIS, V62, P208, DOI 10.1136/ard.62.3.208
   Sloot R., 2016, REUMATISCHE AANDOENI
   Turk SA, 2014, RHEUM DIS CLIN N AM, V40, P753, DOI 10.1016/j.rdc.2014.07.007
   UDEN AM, 1983, ANN RHEUM DIS, V42, P45, DOI 10.1136/ard.42.1.45
   van de Stadt LA, 2013, ANN RHEUM DIS, V72, P1920, DOI 10.1136/annrheumdis-2012-202127
   van Delft MAM, 2019, ANN RHEUM DIS, V78, P146, DOI 10.1136/annrheumdis-2018-213724
   van Middendorp H, 2016, BEST PRACT RES CL RH, V30, P932, DOI 10.1016/j.berh.2016.10.012
   VANRIEL PLCM, 1992, BRIT J RHEUMATOL, V31, P793
   Versteeg G, 2018, CLIN RHEUMATOL, V37, P1189, DOI 10.1007/s10067-017-3962-5
   Versteegh M, 2016, PHARMACOECONOMICS, V34, P1133, DOI 10.1007/s40273-016-0421-0
   WHO, WHO PRIOR MED EUR WO
   Zaiss MM, 2021, NAT REV RHEUMATOL, V17, P224, DOI 10.1038/s41584-021-00585-3
NR 70
TC 28
Z9 28
U1 1
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD OCT 18
PY 2021
VL 22
IS 1
AR 715
DI 10.1186/s13063-021-05682-y
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA WI6NF
UT WOS:000708474000009
PM 34663431
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yao, MY
   Li, LQ
   Ma, JX
   Xue, P
   Li, YK
AF Yao, Ming-yan
   Li, Li-qin
   Ma, Jian-xia
   Xue, Peng
   Li, Yu-kun
TI Use of flash glucose-sensing technology in patients with type 2 diabetes
   treated with liraglutide combined with CSII: a pilot study
SO BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
LA English
DT Article
DE Flash glucose monitoring; Glucagon-like peptide-1 analog; Continuous
   subcutaneous insulin infusion; Glucose fluctuation; Cardiometabolic risk
   markers; Type 2 diabetes
ID INTENSIVE INSULIN THERAPY; OXIDATIVE STRESS; FOLLOW-UP; HYPOGLYCEMIA;
   ADULTS; RISK; COMPLICATIONS; HYPERGLYCEMIA; INFLAMMATION; ADIPONECTIN
AB Glycemic variability (GV) may be linked to the development of diabetic complications by inducing inflammation, oxidative stress, and endothelial dysfunction. Flash glucose monitoring (FGM) provides a novel method of continuously monitoring interstitial glucose levels for up to 14 days. This study randomly assigned poorly controlled type 2 diabetes mellitus patients treated with metformin and multiple daily injections of insulin (n=60) to either continuous subcutaneous insulin infusion (CSII) treatment or CSII in combination with liraglutide (CSII + Lira) treatment for 14 days during hospitalization. GV was assessed using a FGM system; weight and cardiometabolic biomarkers were also evaluated. The coefficient of variation was significantly reduced in the CSII + Lira group (P <0.001), while no significant change was observed in the CSII group. The changes differed significantly between the two groups in mean amplitude of glycemic excursions (P=0.004), standard deviation (P=0.006), and the percentage of time in the target range (4-10 mmol/L, P=0.005 and >10 mmol/L, P=0.028). The changes in mean of daily differences, interquartile range, and percentage of time in hypoglycemia (<3.3 mmol/L) and hyperglycemia (>13.9 mmol/L) identified by FGM showed no difference. Treatment with liraglutide increased serum adiponectin [33.5 (3.5, 47.7) pg/mL, P=0.003] and heme oxygenase-1 levels [0.4 (-0.0, 1.8) ng/mL, P=0.001] and reduced serum leptin levels [-2.8 (3.9) pg/mL, P<0.001]. Adding the glucagon-like peptide-1 analog liraglutide improved GV, weight, and some cardiometabolic risk markers. The FGM system is, therefore, shown to be a novel and useful method for glucose monitoring.
C1 [Yao, Ming-yan; Li, Li-qin; Ma, Jian-xia; Xue, Peng; Li, Yu-kun] Hebei Med Univ, Dept Endocrinol, Hosp 3, Shijiazhuang, Hebei, Peoples R China.
   [Yao, Ming-yan] Baoding 1 Cent Hosp, Dept Endocrinol, Baoding, Hebei, Peoples R China.
C3 Hebei Medical University
RP Li, YK (corresponding author), Hebei Med Univ, Dept Endocrinol, Hosp 3, Shijiazhuang, Hebei, Peoples R China.
EM yhsw667888@163.com
CR Ajjan RA, 2019, DIABETES VASC DIS RE, V16, P3, DOI 10.1177/1479164118795252
   Ajjan RA, 2017, DIABETES TECHNOL THE, V19, pS27, DOI 10.1089/dia.2017.0021
   Bedenis R, 2014, DIABETES CARE, V37, P3301, DOI 10.2337/dc14-0908
   Ceriello A, 2013, DIABETES CARE, V36, P2346, DOI 10.2337/dc12-2469
   Chiefari E, 2015, DIABETES TECHNOL THE, V17, P468, DOI 10.1089/dia.2014.0412
   Chung LTK, 2009, BIOCHEM BIOPH RES CO, V390, P613, DOI 10.1016/j.bbrc.2009.10.015
   Costantino S, 2017, DIABETES, V66, P2472, DOI 10.2337/db17-0294
   Dandona P, 2009, J AM COLL CARDIOL, V53, pS14, DOI 10.1016/j.jacc.2008.10.038
   Duckworth W, 2009, NEW ENGL J MED, V360, P129, DOI 10.1056/NEJMoa0808431
   Farr OM, 2016, METABOLISM, V65, P945, DOI 10.1016/j.metabol.2016.03.009
   FLAT-SUGAR Trial Investigators, 2016, DIABETES CARE, V39, P973, DOI 10.2337/dc15-2782
   Gerstein HC, 2008, NEW ENGL J MED, V358, P2545, DOI 10.1056/NEJMoa0802743
   Hendarto H, 2012, METABOLISM, V61, P1422, DOI 10.1016/j.metabol.2012.03.002
   Hirakawa Y, 2014, DIABETES CARE, V37, P2359, DOI 10.2337/dc14-0199
   Holman RR, 2008, NEW ENGL J MED, V359, P1577, DOI 10.1056/NEJMoa0806470
   Kramer CK, 2013, LANCET DIABETES ENDO, V1, P28, DOI 10.1016/S2213-8587(13)70006-8
   Lane W, 2014, DIABETES OBES METAB, V16, P827, DOI 10.1111/dom.12286
   Lee MK, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-03842-2
   Li DM, 2015, DIABETES RES CLIN PR, V110, P224, DOI 10.1016/j.diabres.2015.05.051
   Maiorino MI, 2018, DIABETES TECHNOL THE, V20, P117, DOI 10.1089/dia.2017.0334
   Marso SP, 2016, NEW ENGL J MED, V375, P311, DOI 10.1056/NEJMoa1603827
   Monnier L, 2006, JAMA-J AM MED ASSOC, V295, P1681, DOI 10.1001/jama.295.14.1681
   Oeseburg H, 2010, ARTERIOSCL THROM VAS, V30, P1407, DOI 10.1161/ATVBAHA.110.206425
   Oh YS, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19010026
   Pokala N, 2017, DIABETES OBES METAB, V19, P1454, DOI 10.1111/dom.12939
   Reddy M, 2018, DIABETES TECHNOL THE, V20, P751, DOI 10.1089/dia.2018.0252
   Rizzo M, 2015, J CLIN ENDOCR METAB, V100, P603, DOI 10.1210/jc.2014-2291
   Rodbard D, 2017, DIABETES TECHNOL THE, V19, pS25, DOI 10.1089/dia.2017.0035
   Sato T, 2019, J DIABETES INVEST, V10, P846, DOI 10.1111/jdi.12954
   Thompson B, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1056-7
   Turner RC, 1998, LANCET, V352, P837, DOI 10.1016/s0140-6736(98)07019-6
   Zhang S, 2019, PHYTOMEDICINE, V57, P385, DOI 10.1016/j.phymed.2018.12.045
   Zhang S, 2012, EUR J PHARMACOL, V692, P78, DOI 10.1016/j.ejphar.2012.05.017
   Zhou BF, 2002, BIOMED ENVIRON SCI, V15, P83
NR 34
TC 6
Z9 6
U1 0
U2 11
PU ASSOC BRAS DIVULG CIENTIFICA
PI RIBEIRAO PRETO
PA FACULDADE MEDICINA, CASA 10, 14049 RIBEIRAO PRETO, RIBEIRAO PRETO, SP
   14049, BRAZIL
SN 0100-879X
EI 1414-431X
J9 BRAZ J MED BIOL RES
JI Brazilian J. Med. Biol. Res.
PY 2020
VL 53
IS 1
AR e8652
DI 10.1590/1414-431X20198652
PG 10
WC Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Research & Experimental
   Medicine
GA JX8SM
UT WOS:000503998800001
PM 31859911
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lago, SG
   Tomasik, J
   van Rees, GF
   Rubey, M
   Gonzalez-Vioque, E
   Ramsey, JM
   Haenisch, F
   Broek, JA
   Vázquez-Bourgon, J
   Papiol, S
   Suarez-Pinilla, P
   Ruland, T
   Auyeug, B
   Mikova, O
   Kabacs, N
   Arolt, V
   Baron-Cohen, S
   Crespo-Facorro, B
   Bahn, S
AF Lago, Santiago G.
   Tomasik, Jakub
   van Rees, Geertje F.
   Rubey, Marina
   Gonzalez-Vioque, Emiliano
   Ramsey, Jordan M.
   Haenisch, Frieder
   Broek, Jantine A.
   Vazquez-Bourgon, Javier
   Papiol, Sergi
   Suarez-Pinilla, Paula
   Ruland, Tillmann
   Auyeug, Bonnie
   Mikova, Olya
   Kabacs, Nikolett
   Arolt, Volker
   Baron-Cohen, Simon
   Crespo-Facorro, Benedicto
   Bahn, Sabine
TI Exploring cellular markers of metabolic syndrome in peripheral blood
   mononuclear cells across the neuropsychiatric spectrum
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Neuropsychiatric conditions; Metabolic syndrome; Peripheral blood
   mononuclear cell; Cell surface marker; Insulin sensitivity; Polygenic
   risk score; Homeostasis model assessment; Antipsychotic treatment;
   Response prediction; Weight gain; Flow cytometry
ID MAJOR DEPRESSIVE DISORDER; 1ST-EPISODE SCHIZOPHRENIA;
   ANTIPSYCHOTIC-DRUGS; PREFRONTAL CORTEX; IMMUNE-SYSTEM; PEOPLE; BRAIN;
   RISK; GLUCOSE-TRANSPORTER-1; METAANALYSIS
AB Recent evidence suggests that comorbidities between neuropsychiatric conditions and metabolic syndrome may precede and even exacerbate long-term side-effects of psychiatric medication, such as a higher risk of type 2 diabetes and cardiovascular disease, which result in increased mortality. In the present study we compare the expression of key metabolic proteins, including the insulin receptor (CD220), glucose transporter 1 (GLUT1) and fatty acid translocase (CD36), on peripheral blood mononuclear cell subtypes from patients across the neuropsychiatric spectrum, including schizophrenia, bipolar disorder, major depression and autism spectrum conditions (n = 25/condition), relative to typical controls (n = 100). This revealed alterations in the expression of these proteins that were specific to schizophrenia. Further characterization of metabolic alterations in an extended cohort of first-onset antipsychotic drug-naive schizophrenia patients (n = 58) and controls (n = 63) revealed that the relationship between insulin receptor expression in monocytes and physiological insulin sensitivity was disrupted in schizophrenia and that altered expression of the insulin receptor was associated with whole genome polygenic risk scores for schizophrenia. Finally, longitudinal follow-up of the schizophrenia patients over the course of antipsychotic drug treatment revealed that peripheral metabolic markers predicted changes in psychopathology and the principal side effect of weight gain at clinically relevant time points. These findings suggest that peripheral blood cells can provide an accessible surrogate model for metabolic alterations in schizophrenia and have the potential to stratify subgroups of patients with different clinical outcomes or a greater risk of developing metabolic complications following antipsychotic therapy.
C1 [Lago, Santiago G.; Tomasik, Jakub; van Rees, Geertje F.; Rubey, Marina; Gonzalez-Vioque, Emiliano; Ramsey, Jordan M.; Haenisch, Frieder; Broek, Jantine A.; Bahn, Sabine] Univ Cambridge, Dept Chem Engn & Biotechnol, Philippa Fawcett Dr, Cambridge CB3 0AS, England.
   [Vazquez-Bourgon, Javier; Suarez-Pinilla, Paula; Auyeug, Bonnie; Crespo-Facorro, Benedicto] Univ Cantabria, Marques Valdecilla Univ Hosp, IDIVAL, Sch Med,Dept Psychiat, Santander, Spain.
   [Vazquez-Bourgon, Javier; Suarez-Pinilla, Paula] Ctr Invest Biomed Red Salud Mental CIBERSAM, Santander, Spain.
   [Papiol, Sergi] Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain.
   [Papiol, Sergi; Crespo-Facorro, Benedicto] Ludwig Maximilians Univ Munchen, Univ Hosp, Inst Psychiat Phen & Genom, Munich, Germany.
   [Papiol, Sergi] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany.
   [Ruland, Tillmann; Arolt, Volker] Univ Hosp Munster, Munster, Germany.
   [Baron-Cohen, Simon] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge, England.
   [Mikova, Olya] Fdn Biol Psychiat, Sofia, Bulgaria.
   [Kabacs, Nikolett] Cambridgeshire & Peterborough NHS Fdn TrustCambri, Cambridge, England.
   [Crespo-Facorro, Benedicto] Univ Hosp Virgen Rocio, Sch Med, Dept Psychiat, IBiS, Seville, Spain.
   [Crespo-Facorro, Benedicto] Ctr Invest Biomed Red Salud Mental CIBERSAM, Seville, Spain.
   [Gonzalez-Vioque, Emiliano] Univ Santiago de Compostela, Unit Diag & Treatment Congenital Metab Dis, Hlth Res Inst Santiago Compostela IDIS, Hosp Clin, Santiago De Compostela, Spain.
   [Auyeug, Bonnie] Univ Edinburgh, Psychol Dept, Edinburgh, Midlothian, Scotland.
C3 University of Cambridge; Hospital Universitario Marques de Valdecilla
   (HUMV); Universidad de Cantabria; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERSAM; CIBER - Centro de Investigacion Biomedica en
   Red; CIBERSAM; University of Munich; University of Munich; University of
   Munster; University of Cambridge; Consejo Superior de Investigaciones
   Cientificas (CSIC); University of Sevilla; CSIC-JA-USE - Instituto de
   Biomedicina de Sevilla (IBIS); Virgen del Rocio University Hospital;
   CIBER - Centro de Investigacion Biomedica en Red; CIBERSAM; Complexo
   Hospitalario Universitario de Santiago de Compostela; Universidade de
   Santiago de Compostela; University of Edinburgh
RP Bahn, S (corresponding author), Univ Cambridge, Dept Chem Engn & Biotechnol, Philippa Fawcett Dr, Cambridge CB3 0AS, England.
EM sb209@cam.ac.uk
RI Tomasik, Jakub/JTS-5325-2023; Vázquez-Bourgon, Javier/H-8496-2019;
   Crespo-Facorro, BENEDICTO/AAY-2238-2021; Baron-Cohen,
   Simon/JPA-2618-2023; Haenisch, Frieder/HTP-2221-2023; Haenisch,
   Frieder/N-1765-2015
OI Vazquez-Bourgon, Javier/0000-0002-5478-3376; van Rees,
   Geertje/0000-0002-9431-0653; Tomasik, Jakub/0000-0002-2127-4487; Dias,
   Debora/0009-0004-6164-5360; Baron-Cohen, Simon/0000-0001-9217-2544;
   Papiol, Sergi/0000-0001-9366-8728; Haenisch,
   Frieder/0000-0001-7961-4467; Crespo-Facorro,
   Benedicto/0000-0003-0033-7132
FU Stanley Medical Research Institute (SMRI); Engineering and Physical
   Sciences Research Council UK (EPSRC); Dutch Government-funded Virgo
   consortium [FES0908]; Netherlands Genomics Initiative [050-060-452];
   European Union FP7 funding scheme: Marie Curie Actions Industry Academia
   Partnerships and Pathways [286334]; MINECO [SAF2016-76046-R,
   SAF2013-46292-R]; ISCIII [PI16/00156]; FEDER [PI16/00156]
FX We are highly indebted to the participants and their families for their
   cooperation in this study. We would like to thank blood donors and the
   clinical centres, for provision of biological samples, in addition to
   support staff at the affiliated institutions. We thank IDIVAL biobank
   (Ines Santiuste and Jana Arozamena) for clinical samples and data as
   well as the PAFIP members for the data collection. This work was
   supported by grants from the Stanley Medical Research Institute (SMRI);
   the Engineering and Physical Sciences Research Council UK (EPSRC); the
   Dutch Government-funded Virgo consortium (ref. FES0908); the Netherlands
   Genomics Initiative (ref. 050-060-452); the European Union FP7 funding
   scheme: Marie Curie Actions Industry Academia Partnerships and Pathways
   (ref. 286334, PSYCH-AID project); SAF2016-76046-R and SAF2013-46292-R
   (MINECO) and PI16/00156 (ISCIII and FEDER).
CR AKISKAL HS, 2000, J AFFECT DISORD S1, V59, pS
   Amare AT, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/tp.2016.261
   American Psychiatric Association (APA), 2013, Diagnostic and Statistical Manual of Mental Disorders, V5th ed
   ANDREASEN NC, 1989, BRITISH JOURNAL OF PSYCHIATRY, VOL 155, SUPP NO. 7, P49
   Bao Y, 2012, J CEREBR BLOOD F MET, V32, P1567, DOI 10.1038/jcbfm.2012.52
   Barone R, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00636
   Berton O, 2006, NAT REV NEUROSCI, V7, P137, DOI 10.1038/nrn1846
   Beumer W, 2012, J LEUKOCYTE BIOL, V92, P959, DOI 10.1189/jlb.0212100
   Bloomfield PS, 2016, AM J PSYCHIAT, V173, P44, DOI 10.1176/appi.ajp.2015.14101358
   Bossuyt PM, 2003, CLIN CHEM, V49, P1, DOI 10.1373/49.1.1
   Boucher J, 2014, CSH PERSPECT BIOL, V6, DOI 10.1101/cshperspect.a009191
   Bromet EJ, 2011, AM J PSYCHIAT, V168, P1186, DOI 10.1176/appi.ajp.2011.11010048
   Chan MK, 2011, INT REV NEUROBIOL, V101, P95, DOI 10.1016/B978-0-12-387718-5.00005-5
   Cheng N, 2017, FRONT MOL NEUROSCI, V10, DOI 10.3389/fnmol.2017.00034
   Cignarelli A, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20030759
   Coello K, 2019, INT J BIPOLAR DISORD, V7, DOI 10.1186/s40345-019-0142-3
   Correll CU, 2014, JAMA PSYCHIAT, V71, P1350, DOI 10.1001/jamapsychiatry.2014.1314
   Craddock RM, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000692
   Crespo-Facorro B, 2019, NPJ SCHIZOPHR, V5, DOI 10.1038/s41537-019-0075-y
   Crespo-Facorro B, 2013, PROG NEURO-PSYCHOPH, V44, P162, DOI 10.1016/j.pnpbp.2013.02.009
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   De Silva PN, 2011, MED HYPOTHESES, V77, P529, DOI 10.1016/j.mehy.2011.06.022
   Debnath M, 2014, SCHIZOPHRENIA BULL, V40, P1412, DOI 10.1093/schbul/sbu049
   Dodington DW, 2018, TRENDS ENDOCRIN MET, V29, P55, DOI 10.1016/j.tem.2017.11.001
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Emamian ES, 2004, NAT GENET, V36, P131, DOI 10.1038/ng1296
   Fillman SG, 2016, MOL PSYCHIATR, V21, P1090, DOI 10.1038/mp.2015.90
   Fillman SG, 2013, MOL PSYCHIATR, V18, P206, DOI 10.1038/mp.2012.110
   Freemerman AJ, 2014, J BIOL CHEM, V289, P7884, DOI 10.1074/jbc.M113.522037
   Glatz JFC, 2010, PHYSIOL REV, V90, P367, DOI 10.1152/physrev.00003.2009
   Grande I, 2016, LANCET, V387, P1561, DOI 10.1016/S0140-6736(15)00241-X
   Guest PC, 2010, MOL PSYCHIATR, V15, P118, DOI 10.1038/mp.2009.81
   Guest PC, 2011, PSYCHONEUROENDOCRINO, V36, P1092, DOI 10.1016/j.psyneuen.2010.12.018
   Guo SD, 2014, J ENDOCRINOL, V220, pT1, DOI 10.1530/JOE-13-0327
   Guo XL, 2005, BIOCHEM GENET, V43, P175, DOI 10.1007/s10528-005-1510-5
   Hajek T, 2015, BIOL PSYCHIAT, V77, P295, DOI 10.1016/j.biopsych.2013.11.007
   Herberth M, 2011, MOL PSYCHIATR, V16, P848, DOI 10.1038/mp.2010.71
   Herberth M, 2010, MOL PSYCHIATR, V15, P364, DOI 10.1038/mp.2008.120
   HOLDEN RJ, 1994, MED HYPOTHESES, V43, P420, DOI 10.1016/0306-9877(94)90020-5
   Howie D, 2018, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01949
   Huhn M, 2014, JAMA PSYCHIAT, V71, P706, DOI 10.1001/jamapsychiatry.2014.112
   Hyman SE, 2008, NATURE, V455, P890, DOI 10.1038/nature07454
   Juncal-Ruiz M, 2018, J NEUROINFLAMM, V15, DOI 10.1186/s12974-018-1096-6
   Jyonouchi H, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20194731
   Kahl KG, 2016, J PSYCHIATR RES, V76, P66, DOI 10.1016/j.jpsychires.2016.02.002
   KAHN BB, 1992, J CELL BIOCHEM, V48, P122, DOI 10.1002/jcb.240480203
   Kahn RS, 2015, NAT REV DIS PRIMERS, V1, DOI 10.1038/nrdp.2015.67
   Kakeda S, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-28300-5
   Kelly DL, 2018, PSYCHIAT RES, V269, P517, DOI 10.1016/j.psychres.2018.09.006
   Kessler RC, 2005, ARCH GEN PSYCHIAT, V62, P593, DOI 10.1001/archpsyc.62.6.593
   Kim EY, 2014, PSYCHOPHARMACOLOGY, V231, P4479, DOI 10.1007/s00213-014-3601-7
   Kroeze WK, 2003, NEUROPSYCHOPHARMACOL, V28, P519, DOI 10.1038/sj.npp.1300027
   Lago SG, 2019, SCI ADV, V5, DOI 10.1126/sciadv.aau9093
   Lago SG, 2020, MOL PSYCHIATR, V25, P2355, DOI 10.1038/s41380-018-0123-4
   Lago SG, 2019, ACS CHEM NEUROSCI, V10, P58, DOI 10.1021/acschemneuro.8b00205
   Lally J, 2015, BRIT MED BULL, V114, P169, DOI 10.1093/bmb/ldv017
   Larsen JR, 2017, JAMA PSYCHIAT, V74, P719, DOI 10.1001/jamapsychiatry.2017.1220
   Lee SH, 2013, NAT GENET, V45, P984, DOI 10.1038/ng.2711
   Leucht S, 2005, BRIT J PSYCHIAT, V187, P366, DOI 10.1192/bjp.187.4.366
   Leucht S, 2013, LANCET, V382, P951, DOI 10.1016/S0140-6736(13)60733-3
   Levy JC, 1998, DIABETES CARE, V21, P2191, DOI 10.2337/diacare.21.12.2191
   Liu JJ, 2020, MOL PSYCHIATR, V25, P339, DOI 10.1038/s41380-019-0474-5
   Lonsdale J, 2013, NAT GENET, V45, P580, DOI 10.1038/ng.2653
   MacNeil Raymond R, 2016, Mol Neuropsychiatry, V2, P61, DOI 10.1159/000445802
   Malan-Müller S, 2016, SCHIZOPHR RES, V170, P1, DOI 10.1016/j.schres.2015.11.011
   Matarese G, 2004, TRENDS IMMUNOL, V25, P193, DOI 10.1016/j.it.2004.02.009
   McDermott E, 2005, MED HYPOTHESES, V65, P1076, DOI 10.1016/j.mehy.2005.06.022
   McGrath J, 2008, EPIDEMIOL REV, V30, P67, DOI 10.1093/epirev/mxn001
   Melkersson K, 2011, NEUROENDOCRINOL LETT, V32, P634
   Merikangas KR, 2011, ARCH GEN PSYCHIAT, V68, P241, DOI 10.1001/archgenpsychiatry.2011.12
   Meyer JM, 2009, ACTA PSYCHIAT SCAND, V119, P4, DOI 10.1111/j.1600-0447.2008.01317.x
   Miller BJ, 2011, BIOL PSYCHIAT, V70, P663, DOI 10.1016/j.biopsych.2011.04.013
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Orihuela R, 2016, BRIT J PHARMACOL, V173, P649, DOI 10.1111/bph.13139
   Pascual JM, 2004, EUR J ENDOCRINOL, V150, P627, DOI 10.1530/eje.0.1500627
   PETTEGREW JW, 1991, ARCH GEN PSYCHIAT, V48, P563
   Pillinger T, 2017, JAMA PSYCHIAT, V74, P261, DOI 10.1001/jamapsychiatry.2016.3803
   Polter A., 2010, DEFICIENCY INHIBITOR
   R Core Team, 2017, R: A Language and Environment for Statistical Computing
   Rahmoune H, 2013, REV PSIQ CLIN-BRAZIL, V40, P28
   Raison CL, 2013, JAMA PSYCHIAT, V70, P31, DOI 10.1001/2013.jamapsychiatry.4
   Ransohoff RM, 2016, NAT NEUROSCI, V19, P987, DOI 10.1038/nn.4338
   Rapaport MH, 2010, NEUROPSYCHOPHARMACOL, V35, P428, DOI 10.1038/npp.2009.145
   Ripke S, 2014, NATURE, V511, P421, DOI 10.1038/nature13595
   Schooler NR, 2015, SCHIZOPHR RES, V162, P169, DOI 10.1016/j.schres.2014.12.001
   Schwarz E, 2015, WORLD J BIOL PSYCHIA, V16, P22, DOI 10.3109/15622975.2013.817685
   Schwarz E, 2014, SCHIZOPHRENIA BULL, V40, P787, DOI 10.1093/schbul/sbt105
   Sekar A, 2016, NATURE, V530, P177, DOI 10.1038/nature16549
   Shibata T, 2013, PROG NEURO-PSYCHOPH, V43, P222, DOI 10.1016/j.pnpbp.2013.01.003
   Silverstein Roy L, 2009, Cleve Clin J Med, V76 Suppl 2, pS27, DOI 10.3949/ccjm.76.s2.06
   Silverstein RL, 2009, SCI SIGNAL, V2, DOI 10.1126/scisignal.272re3
   Stahl Eli A, 2019, Nat Genet, V51, P793, DOI 10.1038/s41588-019-0397-8
   Steiner J, 2010, EUR ARCH PSY CLIN N, V260, P509, DOI 10.1007/s00406-010-0098-x
   Sullivan CR, 2019, MOL PSYCHIATR, V24, P1319, DOI 10.1038/s41380-018-0035-3
   Sullivan PF, 2006, AM J MED GENET B, V141B, P261, DOI 10.1002/ajmg.b.30272
   Suzuki K, 2013, JAMA PSYCHIAT, V70, P49, DOI 10.1001/jamapsychiatry.2013.272
   Thomas MSC, 2016, DEVELOPMENTAL SCI, V19, P284, DOI 10.1111/desc.12303
   Tomasik J, 2019, JAMA PSYCHIAT, V76, P864, DOI 10.1001/jamapsychiatry.2019.0304
   Tomasik J, 2016, BRAIN BEHAV IMMUN, V52, P178, DOI 10.1016/j.bbi.2015.10.019
   Trépanier MO, 2016, MOL PSYCHIATR, V21, P1009, DOI 10.1038/mp.2016.90
   van Beveren NJM, 2014, TRANSL PSYCHIAT, V4, DOI 10.1038/tp.2014.52
   van Kesteren CFMG, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/tp.2017.4
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vestri HS, 2007, NEUROPSYCHOPHARMACOL, V32, P765, DOI 10.1038/sj.npp.1301142
   Wang LX, 2019, MOL NEURODEGENER, V14, DOI 10.1186/s13024-019-0305-9
   Wang XL, 2006, DIABETES, V55, P2301, DOI 10.2337/db05-1574
   Wong ML, 2004, NAT REV DRUG DISCOV, V3, P136, DOI 10.1038/nrd1303
   World Med Assoc, 2013, JAMA-J AM MED ASSOC, V310, P2191, DOI 10.1001/jama.2013.281053
   Wray NR, 2014, J CHILD PSYCHOL PSYC, V55, P1068, DOI 10.1111/jcpp.12295
   Zhang JP, 2019, AM J PSYCHIAT, V176, P21, DOI 10.1176/appi.ajp.2018.17121363
   Zhong Z, 2006, SCHIZOPHR RES, V84, P1, DOI 10.1016/j.schres.2006.02.009
NR 112
TC 15
Z9 15
U1 2
U2 13
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD JAN
PY 2021
VL 91
BP 673
EP 682
DI 10.1016/j.bbi.2020.07.043
PG 10
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA PL4LY
UT WOS:000603096600007
PM 32898636
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Santos-Calderón, LA
   Vargas-Morales, JM
   Capello, OSA
   Terán-García, M
   Cossío-Torres, PE
   Vidal-Batres, M
   Fernández-Ballart, JD
   Aradillas-García, C
AF Adolfo Santos-Calderon, Luis
   Manuel Vargas-Morales, Juan
   Sanchez-Armass Capello, Omar
   Teran-Garcia, Margarita
   Elizabeth Cossio-Torres, Patricia
   Vidal-Batres, Marisol
   Fernandez-Ballart, Joan D.
   Aradillas-Garcia, Celia
CA UP AMIGOS Team
TI Association between birthweight, cardiovascular risk factors, and
   depression in young Mexican adults
SO NUTRICION HOSPITALARIA
LA English
DT Article
DE Birthweight; Cardiovascular risk; Depression; Mexican population
ID SYSTOLIC BLOOD-PRESSURE; METABOLIC SYNDROME; GESTATIONAL-AGE; DISORDERS;
   ORIGINS; ADOLESCENTS; PREVENTION; CHILDHOOD; CHILDREN; DISEASE
AB Background: the aim of this study was to investigate the association between birthweight, cardiovascular disease (CVD) risk factors, and depression in young Mexican adults.
   Methods: birthweight reports, family history of CVD and diabetes-related diseases, anthropometrics, serum lipid profile (total cholesterol [TC], triglycerides [TG], high-density lipoprotein-cholesterol [HDL-C], low-density lipoprotein-cholesterol [LDL-C], and very-low density lipoprotein-cholesterol [VLDL-C]), and depressive symptoms were measured in 778 subjects of the UP-AMIGOS cohort study. To investigate the association between birthweight categories and CVD risk factors and depression, a one-way analysis of variance with post-hoc test was performed of quantitative variables, and chi(2) test for qualitative variables.
   Results: mean age was 17.8 years and 469 (60.3 %) of patients were female (n = 469, 60.3 %). The percentage of patients with low birthweight (LBW) was 8.1 % (n = 63), and 3.3 % (n = 26) reported high birthweight (HBW). Young adults with HBW were associated with elevated diastolic blood pressure (DBP), and high weight and body mass index (BMI) when compared to LBW subjects, the difference being statically significant (p < 0.05). Birthweight had no significant association with depression (p > 0.67).
   Conclusion: the findings from this population-based study revealed a positive relation between birthweight categories and some CVD risk factors. Depression was not related to birthweight.
C1 [Adolfo Santos-Calderon, Luis] Univ Autonoma San Luis Potosi, Fac Med, San Luis Potosi, San Luis Potosi, Mexico.
   [Manuel Vargas-Morales, Juan] Univ Autonoma San Luis Potosi, Fac Ciencias Quim, San Luis Potosi, San Luis Potosi, Mexico.
   [Sanchez-Armass Capello, Omar] Univ Autonoma San Luis Potosi, Fac Psicol, San Luis Potosi, San Luis Potosi, Mexico.
   [Teran-Garcia, Margarita] Univ Illinois, Champaign, IL 61820 USA.
   [Elizabeth Cossio-Torres, Patricia] Univ Autonoma San Luis Potosi, Dept Salud Publ, Fac Med, San Luis Potosi, San Luis Potosi, Mexico.
   [Vidal-Batres, Marisol] Univ Autonoma San Luis Potosi, Coordinac Innovac & Aplicac Ciencia & Tecnol CIAC, San Luis Potosi, San Luis Potosi, Mexico.
   [Fernandez-Ballart, Joan D.] Univ Rovira & Virgili, Med Prevent & Salud Publ, Fac Med & Ciencias Salud, Tarragona, Spain.
   [Aradillas-Garcia, Celia] Univ Autonoma San Luis Potosi, Ctr Invest Aplicada Ambiente & Salud CIAAS, Fac Med, CIACYT, Av Sierra Leona 550-2a, San Luis Potosi 78210, San Luis Potosi, Mexico.
C3 Universidad Autonoma de San Luis Potosi; Universidad Autonoma de San
   Luis Potosi; Universidad Autonoma de San Luis Potosi; University of
   Illinois System; University of Illinois Urbana-Champaign; Universidad
   Autonoma de San Luis Potosi; Universidad Autonoma de San Luis Potosi;
   Universitat Rovira i Virgili; Universidad Autonoma de San Luis Potosi
RP Aradillas-García, C (corresponding author), Univ Autonoma San Luis Potosi, Ctr Invest Aplicada Ambiente & Salud CIAAS, Fac Med, CIACYT, Av Sierra Leona 550-2a, San Luis Potosi 78210, San Luis Potosi, Mexico.
EM celia@uaslp.com
RI Garcia, Celia/B-5830-2014; Teran-Garcia, Margarita/B-5344-2009;
   Cossio-Torres, Patricia/AAA-3632-2021; Santos Calderon,
   Luis/HJI-3458-2023; Fernández Barredo, Juan/JLK-8499-2023
OI Vidal-Batres, Marisol/0000-0002-8245-6065; Cossio-Torres, Patricia
   Elizabeth/0000-0002-7626-8949; Sanchez-Armass, Omar/0000-0001-8064-2502;
   Santos Calderon, Luis Adolfo/0000-0002-6871-1103; Fernandez-Ballart,
   Joan D./0000-0002-1320-6484
FU UASLP Hormones Laboratory at the School of Medicine [C09-PIFI-030606];
   UASLP Hormones Laboratory at the Clinical Biochemistry Laboratory
   [C09-PIFI-030606]; UASLP Hormones Laboratory at the Chemical Sciences
   School [C09-PIFI-030606]; University of Illinois at Urbana-Champaign
   Research Board [09070]; University of Illinois at Center on Health,
   Aging, and Disability; USDA National Institute of Food and Agriculture,
   Hatch Projects [600108-793000-793323, 600109-698000-698354]; UASLP
   Hormones Laboratory at the University Health Center [C09-PIFI-030606]
FX this research was funded by grants from the UASLP Hormones Laboratory at
   the School of Medicine, Clinical Biochemistry Laboratory, Chemical
   Sciences School, and the University Health Center under agreement
   support C09-PIFI-030606 (to C. Aradillas-Garcia); the University of
   Illinois at Urbana-Champaign Research Board (#09070) and Center on
   Health, Aging, and Disability (to F. Andrade); and the USDA National
   Institute of Food and Agriculture, Hatch Projects #600108-793000793323
   (to M. Raffaelli) and #600109-698000-698354 (to M. Teran-Garcia).
CR Alati R, 2009, INT J EPIDEMIOL, V38, P1390, DOI 10.1093/ije/dyp252
   [Anonymous], 2011, REV MEX PEDIAT
   Arafat S, 2018, TWIN RES HUM GENET, V21, P485, DOI 10.1017/thg.2018.65
   Azadbakht L, 2014, NUTRITION, V30, P150, DOI 10.1016/j.nut.2013.06.005
   Barker DJP, 2007, J INTERN MED, V261, P412, DOI 10.1111/j.1365-2796.2007.01809.x
   Chapela IB, 2009, SALUD MENT, V32, P299
   Carson C, 2018, PHYSIOL GENOMICS, V50, P947, DOI 10.1152/physiolgenomics.00072.2018
   Chen W, 2012, AM J EPIDEMIOL, V176, pS99, DOI 10.1093/aje/kws298
   de Rooij SR, 2007, AM J CLIN NUTR, V86, P1219, DOI 10.1093/ajcn/86.4.1219
   Alves PDD, 2015, J PEDIATR ENDOCR MET, V28, P407, DOI 10.1515/jpem-2014-0146
   Fujita Y, 2013, J EPIDEMIOL, V23, P103, DOI 10.2188/jea.JE20120107
   Gilstrap LG, 2013, J WOMENS HEALTH, V22, P322, DOI 10.1089/jwh.2012.3854
   González-Jiménez E, 2015, EUR J NUTR, V54, P589, DOI 10.1007/s00394-014-0740-x
   Guerrero-Romero F, 2010, J PEDIATR-US, V156, P719, DOI 10.1016/j.jpeds.2009.11.043
   Herrera E, 2014, CURR PHARM BIOTECHNO, V15, P24, DOI 10.2174/1389201015666140330192345
   Huffman JC, 2010, NEUROPSYCH DIS TREAT, V6, P123
   Jellinger PS, 2017, ENDOCR PRACT, V23, P1, DOI 10.4158/EP171764.APPGL
   Kelishadi R, 2015, PAEDIATR INT CHILD H, V35, P110, DOI 10.1179/2046905514Y.0000000136
   Kuciene R, 2018, EUR J NUTR, V57, P373, DOI 10.1007/s00394-016-1372-0
   Lin XH, 2016, ONCOTARGET, V7, P86511, DOI 10.18632/oncotarget.13442
   Lindberg J, 2017, AM J CLIN NUTR, V106, P475, DOI 10.3945/ajcn.116.150482
   Lurbe E, 2014, HYPERTENSION, V63, P1326, DOI 10.1161/HYPERTENSIONAHA.114.03137
   Mandy M, 2018, INT HEALTH, V10, P66, DOI 10.1093/inthealth/ihy006
   García RMM, 2017, NUTR HOSP, V34, P53, DOI 10.20960/nh.1572
   Nomura Y, 2007, COMPR PSYCHIAT, V48, P470, DOI 10.1016/j.comppsych.2007.04.005
   O'Neil A, 2012, SOC PSYCH PSYCH EPID, V47, P1145, DOI 10.1007/s00127-011-0421-5
   Okada T, 2015, PEDIATR RES, V77, P136, DOI 10.1038/pr.2014.164
   Santos-Veloso MAO, 2019, REV ASSOC MED BRAS, V65, P801, DOI 10.1590/1806-9282.65.6.801
   Raffaelli M., 2013, REV INTERAMERICANA P, V1, P83, DOI DOI 10.30849/rip/ijp.v47i1.204
   Raffaelli M, 2013, J RES ADOLESCENCE, V23, P283, DOI 10.1111/jora.12006
   Reinehr T, 2009, EUR J ENDOCRINOL, V160, P579, DOI 10.1530/EJE-08-0914
   Richardson LJ, 2011, ANN EPIDEMIOL, V21, P598, DOI 10.1016/j.annepidem.2011.02.012
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Sun D, 2018, INT J OBESITY, V42, P20, DOI 10.1038/ijo.2017.196
   UNICEF-WHO, 2015, LOW BIRTH WEIGHT PRE
   Wang J, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071568
   Wilson FH, 2004, SCIENCE, V306, P1190, DOI 10.1126/science.1102521
   Yeung SLA, 2016, SCI REP-UK, V6, DOI 10.1038/srep38420
   Yu ZB, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061627
   Zanetti D, 2018, CIRC-GENOM PRECIS ME, V11, DOI 10.1161/CIRCGEN.117.002054
NR 40
TC 1
Z9 1
U1 1
U2 5
PU ARAN EDICIONES, S L
PI MADRID
PA C/ CASTELLO, 128, 1O, MADRID, 28006, SPAIN
SN 0212-1611
EI 1699-5198
J9 NUTR HOSP
JI Nutr. Hosp.
PD JUL-AUG
PY 2021
VL 38
IS 4
BP 833
EP 838
AR 03547
DI 10.20960/nh.03547
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA TP9OS
UT WOS:000677922200023
PM 34120446
OA gold
DA 2025-06-11
ER

PT J
AU Li, FL
   Tang, H
   Xiao, FR
   Gong, JL
   Peng, Y
   Meng, XL
AF Li, Fenglin
   Tang, Hong
   Xiao, Furen
   Gong, Jingli
   Peng, Yong
   Meng, Xiangle
TI Protective Effect of Salidroside from Rhodiolae Radix on
   Diabetes-Induced Oxidative Stress in Mice
SO MOLECULES
LA English
DT Article
DE oxidative stress; diabetes mellitus; salidroside; hypoglycemic; mice
ID METABOLIC SYNDROME; IN-VITRO; EXTRACT; SACHALINENSIS; THERAPY; ACID
AB It has been confirmed that diabetes mellitus (DM) carries increased oxidative stress. This study evaluated the effects of salidroside from Rhodiolae Radix on diabetes-induced oxidative stress in mice. After induction of diabetes, diabetic mice were administered daily doses of 50, 100 and 200 mg/kg salidroside for 28 days. Body weights, fasting blood glucose (FBG), serum insulin, TC (total cholesterol), TG (triglyceride), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were measured. Results showed that salidroside possessed hypoglycemic activity and protective effects against diabetes-induced oxidative stress, which could significantly reduce FBG, TC, TG and MDA levels, and at same time increase serum insulin levels, SOD, GPx and CAT activities. Therefore, salidroside should be considered as a candidate for future studies on diabetes.
C1 [Li, Fenglin; Xiao, Furen] Yanshan Univ, Coll Mat Sci & Engn, Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Peoples R China.
   [Li, Fenglin; Gong, Jingli] Jilin Agr Sci & Technol Coll, Dept Bioengn, Jilin 132101, Peoples R China.
   [Tang, Hong] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Endocrinol, Shanghai 200032, Peoples R China.
   [Peng, Yong] Yanshan Univ, Coll Environm & Chem Engn, Qinhuangdao 066004, Peoples R China.
   [Meng, Xiangle] Henan Coll Tradit Chinese Med, Dept Pharm, Affiliated Hosp 1, Zhengzhou 450000, Peoples R China.
C3 Yanshan University; Jilin Agricultural Science & Technology University;
   Shanghai University of Traditional Chinese Medicine; Yanshan University;
   Henan University of Traditional Chinese Medicine
RP Xiao, FR (corresponding author), Yanshan Univ, Coll Mat Sci & Engn, Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Peoples R China.
EM swgclfl@163.com; lhhong_tang@qq.com; swgclifenglin@sina.com;
   591142473@qq.com; py81ysu@126.com; mxiangle@yahoo.cn
OI Xiao, Furen/0000-0002-3076-2730
FU Natural Sciences Foundation of Jilin Province [20090905]; Natural
   Science Foundation for Young Scientists of Jilin Agricultural Science
   and Technology College [2010124]
FX This work was supported by the Natural Sciences Foundation of Jilin
   Province (Grant No. 20090905) and Natural Science Foundation for Young
   Scientists of Jilin Agricultural Science and Technology College (Grant
   No. 2010124).
CR Ahmed I, 1998, DIABETES RES CLIN PR, V40, P145, DOI 10.1016/S0168-8227(98)00022-9
   [Anonymous], 2010, Int J Pharmaceut Sci Rev Res
   Aronson D, 2002, CARDIOVASC DIABETOL, V1, DOI 10.1186/1475-2840-1-1
   Attele AS, 2002, DIABETES, V51, P1851, DOI 10.2337/diabetes.51.6.1851
   Bikopoulos G, 2008, J ENDOCRINOL, V196, P455, DOI 10.1677/JOE-07-0174
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Cemek M, 2008, J NAT MED-TOKYO, V62, P284, DOI 10.1007/s11418-008-0228-1
   Cui X., 2007, LISHIZHEN MED MAT ME, V18, P611
   Davidson Michael H., 2006, Metabolic Syndrome and Related Disorders, V4, P299, DOI 10.1089/met.2006.4.299
   DeFronzo RA, 1999, ANN INTERN MED, V131, P281, DOI 10.7326/0003-4819-131-4-199908170-00008
   Dias AS, 2005, J NUTR, V135, P2299, DOI 10.1093/jn/135.10.2299
   Elmali Esra, 2004, Drugs R D, V5, P203, DOI 10.2165/00126839-200405040-00003
   Farag YMK, 2011, NEPHROL DIAL TRANSPL, V26, P28, DOI 10.1093/ndt/gfq576
   Gao DW, 2009, METHOD FIND EXP CLIN, V31, P375, DOI 10.1358/mf.2009.31.6.1380457
   Gu Y, 2010, TALANTA, V81, P766, DOI 10.1016/j.talanta.2010.01.015
   Gupta V, 2008, FOOD CHEM TOXICOL, V46, P1645, DOI 10.1016/j.fct.2007.12.027
   He ZH, 2004, ENDOCRIN METAB CLIN, V33, P215, DOI 10.1016/j.ecl.2003.12.003
   Hong JI, 2004, CARCINOGENESIS, V25, P1671, DOI 10.1093/carcin/bgh165
   Inzucchi SE, 2002, JAMA-J AM MED ASSOC, V287, P360, DOI 10.1001/jama.287.3.360
   Jain N, 2010, J PHARM PHARMACOL, V62, P115, DOI 10.1211/jpp.62.01.0013
   Zheng J, 2007, ASIA PAC J CLIN NUTR, V16, P427
   Kalaiarasi P, 2009, EUR J PHARMACOL, V606, P269, DOI 10.1016/j.ejphar.2008.12.057
   Kanter M, 2009, J MOL HISTOL, V40, P379, DOI 10.1007/s10735-009-9251-0
   King GL, 2004, HISTOCHEM CELL BIOL, V122, P333, DOI 10.1007/s00418-004-0678-9
   Kucinskaite Agne, 2004, Medicina (Kaunas), V40, P614
   Lau CH, 2008, PHYTOTHER RES, V22, P1384, DOI 10.1002/ptr.2513
   Li FL, 2009, AFR J TRADIT COMPLEM, V6, P195
   Li HB, 2001, J CHROMATOGR A, V932, P91, DOI 10.1016/S0021-9673(01)01232-8
   Li WL, 2004, J ETHNOPHARMACOL, V92, P1, DOI 10.1016/j.jep.2003.12.031
   Mao GX, 2010, MECH AGEING DEV, V131, P723, DOI 10.1016/j.mad.2010.10.003
   Maritim AC, 2003, J BIOCHEM MOL TOXIC, V17, P24, DOI 10.1002/jbt.10058
   Megalli S, 2006, J PHARM PHARM SCI, V9, P281
   Mitra S. K., 1995, Indian Journal of Experimental Biology, V33, P798
   Mizuno CS, 2008, CURR MED CHEM, V15, P61
   Omar HS, 2011, THESCIENTIFICWORLDJO, V11, P788, DOI 10.1100/tsw.2011.71
   Parhizkar S, 2011, J MED PLANTS RES, V5, P1478
   Pari L., 2002, SMJ Singapore Medical Journal, V43, P617
   Pennathur S, 2007, ANTIOXID REDOX SIGN, V9, P955, DOI 10.1089/ars.2007.1595
   Qi XY, 2008, NUTR RES, V28, P278, DOI 10.1016/j.nutres.2008.02.008
   Rajagopal K, 2008, SINGAP MED J, V49, P137
   Sathishsekar D, 2005, ASIA PAC J CLIN NUTR, V14, P153
   Scheen AJ, 1998, DRUGS, V55, P225
   Shaw JE, 2010, DIABETES RES CLIN PR, V87, P4, DOI 10.1016/j.diabres.2009.10.007
   Sivakumar S, 2010, FREE RADICAL RES, V44, P668, DOI 10.3109/10715761003733901
   Skopinska-Rózewska E, 2008, POL J VET SCI, V11, P97
   Tong B. D., 2008, CHIN J CLIN NUTR, V16, P129
   Triggiani Vincenzo, 2006, Endocrine Metabolic & Immune Disorders-Drug Targets, V6, P77
   Varma S B, 2010, Int J Ayurveda Res, V1, P163, DOI 10.4103/0974-7788.72488
   Wen Xiu-ying, 2008, Zhong Xi Yi Jie He Xue Bao, V6, P289
   Wu YL, 2008, BIOL PHARM BULL, V31, P1523, DOI 10.1248/bpb.31.1523
   Wu YL, 2009, J PHARM PHARMACOL, V61, P1375, DOI [10.1211/jpp/61.10.0015, 10.1211/jpp.61.10.0015]
   Xie JT, 2005, BBA-MOL BASIS DIS, V1740, P319, DOI 10.1016/j.bbadis.2004.10.010
   Xue SX, 2009, CARBOHYD POLYM, V75, P415, DOI 10.1016/j.carbpol.2008.08.003
   Yokozawa T, 2004, AM J CHINESE MED, V32, P829, DOI 10.1142/S0192415X04002442
   Zhou XF, 2007, BIOL PHARM BULL, V30, P439, DOI 10.1248/bpb.30.439
NR 55
TC 75
Z9 88
U1 2
U2 37
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1420-3049
J9 MOLECULES
JI Molecules
PD DEC
PY 2011
VL 16
IS 12
BP 9912
EP 9924
DI 10.3390/molecules16129912
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 866UQ
UT WOS:000298411200011
PM 22134398
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Minami, A
   Matsushita, H
   Leno, D
   Matsuda, Y
   Horii, Y
   Ishii, A
   Takahashi, T
   Kanazawa, H
   Wakatsuki, A
   Suzuki, T
AF Minami, A.
   Matsushita, H.
   Leno, D.
   Matsuda, Y.
   Horii, Y.
   Ishii, A.
   Takahashi, T.
   Kanazawa, H.
   Wakatsuki, A.
   Suzuki, T.
TI Improvement of neurological disorders in postmenopausal model rats by
   administration of royal jelly
SO CLIMACTERIC
LA English
DT Article
DE Royal jelly; estrogen; memory impairment; depression; ovariectomized
   rat; postmenopausal; syndrome; fatty acids; sterols
ID ESTROGEN-RECEPTOR-ALPHA; HORMONE REPLACEMENT THERAPY; RECOGNITION
   MEMORY; ESTRADIOL; WOMEN; BEHAVIOR; BETA; DEPRESSION; AGONIST; CELLS
AB Objective: Royal jelly (RJ) from honeybees (Apis mellifera) has estrogenic activity. Estrogen deficiency after menopause leads to a high risk of memory impairment and depression as well as metabolic syndrome and osteoporosis. We here investigated the effect of RJ on memory impairment and depression-like behaviors in ovariectomized (OVX) rats.
   Methods: OVX rats were administered with RJ for 82 days. Hippocampus-dependent spatial memory and depression-like behaviors were assessed by the Morris water maze test and the forced swimming test, respectively. The weights of body, brain and uterus and the contents of protein and myelin galactolipids including galactosylceramide and sulfatide were measured.
   Results: Memory impairment and depression-like behaviors in OVX rats were recovered to the levels of sham-operated rats by RJ administration. Increased body weight and decreased uterine weight in OVX rats were recovered to the levels of sham-operated rats by 17 beta-estradiol (E2) administration but not by RJ administration. In contrast, brain weight was slightly increased by RJ administration but not by E2 administration. The contents of protein and myelin galactolipids were higher in the brains of RJ-administered OVX rats than in the brains of E2-administered OVX rats.
   Conclusion: The results suggest that RJ has a beneficial effect on neurological symptoms of a menopausal disorder.
C1 [Minami, A.; Leno, D.; Matsuda, Y.; Horii, Y.; Ishii, A.; Takahashi, T.; Suzuki, T.] Univ Shizuoka, Sch Pharmaceut Sci, Dept Biochem, Shizuoka, Japan.
   [Matsushita, H.; Wakatsuki, A.] Aichi Med Univ, Sch Med, Dept Obstet & Gynecol, Nagakute, Aichi, Japan.
   [Kanazawa, H.] Univ Shizuoka, Sch Nursing, Dept Funct Anat, Shizuoka, Japan.
C3 University of Shizuoka; Aichi Medical University; University of Shizuoka
RP Suzuki, T (corresponding author), Univ Shizuoka, Sch Pharmaceut Sci, Dept Biochem, Suruga Ku, 52-1 Yada, Shizuoka 4228526, Japan.
EM suzukit@u-shizuoka-ken.ac.jp
RI Matsushita, Hiroshi/AFQ-0956-2022
FU Japan Society for Menopause and Women's Health under JMWH Bayer Grant;
   Yamada Bee Company under Yamada Research Grant; Kanae Foundation for the
   Promotion of Medical Science under Asia Oceania Collaborative Research
   Grants; Japan Menopause Society under JMS Bayer Schering Pharma Grant;
   Grants-in-Aid for Scientific Research [15H05644, 16K15151, 16K08277]
   Funding Source: KAKEN
FX This research was supported by the Japan Society for Menopause and
   Women's Health under the JMWH Bayer Grant; Yamada Bee Company under the
   Yamada Research Grant; and The Kanae Foundation for the Promotion of
   Medical Science under the Asia Oceania Collaborative Research Grants to
   A.M and by the Japan Menopause Society under the JMS Bayer Schering
   Pharma Grant to H.M.
CR ALBERT DJ, 1991, PHYSIOL BEHAV, V49, P225, DOI 10.1016/0031-9384(91)90036-N
   Albertazzi P, 2002, CLIMACTERIC, V5, P190, DOI 10.1080/713605224
   Andruska N, 2015, ONCOGENE, V34, P3760, DOI 10.1038/onc.2014.292
   Beltran-Campos V, 2011, BRAIN RES, V1369, P119, DOI 10.1016/j.brainres.2010.10.105
   BERNARDI M, 1989, PHYSIOL BEHAV, V45, P1067, DOI 10.1016/0031-9384(89)90238-2
   Bincoletto C, 2005, INT IMMUNOPHARMACOL, V5, P679, DOI 10.1016/j.intimp.2004.11.015
   Chiang SS, 2013, APPL MICROBIOL BIOT, V97, P1489, DOI 10.1007/s00253-012-4675-y
   Coetzee T, 1998, TRENDS NEUROSCI, V21, P126, DOI 10.1016/S0166-2236(97)01178-8
   Estrada-Camarena E, 2003, NEUROPSYCHOPHARMACOL, V28, P830, DOI 10.1038/sj.npp.1300097
   Freeman EW, 2006, ARCH GEN PSYCHIAT, V63, P375, DOI 10.1001/archpsyc.63.4.375
   Gapstur SM, 2015, LANCET, V385, P1835, DOI 10.1016/S0140-6736(14)61687-1
   Geary N, 2001, ENDOCRINOLOGY, V142, P4751, DOI 10.1210/en.142.11.4751
   Gentile S, 2005, CNS SPECTRUMS, V10, P944, DOI 10.1017/S1092852900010518
   Halbreich U, 1997, NEUROLOGY, V48, pS16, DOI 10.1212/WNL.48.5_Suppl_7.16S
   Hattori N, 2007, BIOMED RES-TOKYO, V28, P261, DOI 10.2220/biomedres.28.261
   Hattori N, 2007, BIOMED RES-TOKYO, V28, P139, DOI 10.2220/biomedres.28.139
   Henderson VW, 2008, CLIN OBSTET GYNECOL, V51, P618, DOI 10.1097/GRF.0b013e318180ba10
   Heydarpour P, 2013, HORM BEHAV, V63, P361, DOI 10.1016/j.yhbeh.2012.12.005
   Hyde JS, 2008, PSYCHOL REV, V115, P291, DOI 10.1037/0033-295X.115.2.291
   Jacome LF, 2010, NEUROBIOL LEARN MEM, V94, P488, DOI 10.1016/j.nlm.2010.08.016
   Kandi P, 2011, BRAIN RES BULL, V84, P224, DOI 10.1016/j.brainresbull.2010.12.012
   Korach KS, 2000, J SOC GYNECOL INVEST, V7, pS16, DOI 10.1177/1071557600007001S06
   Koundi KL, 2006, GYNECOL ENDOCRINOL, V22, P660, DOI 10.1080/09513590601010557
   Kurita T, 2001, BIOL REPROD, V64, P272, DOI 10.1095/biolreprod64.1.272
   LeBlanc ES, 2001, JAMA-J AM MED ASSOC, V285, P1489, DOI 10.1001/jama.285.11.1489
   Lethaby A, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003122.pub2
   Low LF, 2006, NEUROSCI BIOBEHAV R, V30, P66, DOI 10.1016/j.neubiorev.2005.05.003
   Lubbers LS, 2010, J STEROID BIOCHEM, V122, P310, DOI 10.1016/j.jsbmb.2010.08.005
   Luine VN, 2012, FRONT NEUROENDOCRIN, V33, P388, DOI 10.1016/j.yfrne.2012.07.004
   Micevych PE, 2008, MOL NEUROBIOL, V38, P66, DOI 10.1007/s12035-008-8034-z
   Minami A, 2013, BIOL PHARM BULL, V36, P1990, DOI 10.1248/bpb.b13-00657
   Moutsatsou P, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015594
   National Collaborating Centre for Women's and Children's Health, 2015, MEN CLIN GUID METH E
   Okamoto I, 2003, LIFE SCI, V73, P2029, DOI 10.1016/S0024-3205(03)00562-9
   Persson I, 1999, CANCER CAUSE CONTROL, V10, P253, DOI 10.1023/A:1008909128110
   Rachman IM, 1998, P NATL ACAD SCI USA, V95, P13941, DOI 10.1073/pnas.95.23.13941
   Rasgon NL, 2007, J PSYCHIATR RES, V41, P338, DOI 10.1016/j.jpsychires.2006.03.009
   Récamier-Carballo S, 2012, BEHAV BRAIN RES, V233, P351, DOI 10.1016/j.bbr.2012.05.034
   Rocha BA, 2005, PSYCHOPHARMACOLOGY, V179, P637, DOI 10.1007/s00213-004-2078-1
   Scafonas A, 2008, J STEROID BIOCHEM, V110, P197, DOI 10.1016/j.jsbmb.2007.10.013
   Schmidt PJ, 2005, ANN NY ACAD SCI, V1052, P27, DOI 10.1196/annals.1347.003
   Seidlova-Wuttke D, 2008, BONE, V43, P849, DOI 10.1016/j.bone.2008.07.237
   Sherwin BB, 1996, J CLIN ENDOCR METAB, V81, P2545, DOI 10.1210/jc.81.7.2545
   Suzuki KM, 2008, EVID-BASED COMPL ALT, V5, P295, DOI 10.1093/ecam/nem036
   Vega-Rivera NM, 2013, NEUROSCIENCE, V250, P102, DOI 10.1016/j.neuroscience.2013.06.058
   Walf AA, 2008, NEUROPSYCHOPHARMACOL, V33, P431, DOI 10.1038/sj.npp.1301416
   Wallace M, 2006, BRAIN RES, V1126, P176, DOI 10.1016/j.brainres.2006.07.064
   Wang YF, 2013, J NAT MED-TOKYO, V67, P222, DOI 10.1007/s11418-012-0655-x
   Woolley CS, 1997, J NEUROSCI, V17, P1848
   Wroolie TE, 2015, AM J GERIAT PSYCHIAT, V23, P1117, DOI 10.1016/j.jagp.2015.05.009
NR 50
TC 27
Z9 30
U1 0
U2 17
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1369-7137
EI 1473-0804
J9 CLIMACTERIC
JI Climacteric
PD DEC
PY 2016
VL 19
IS 6
BP 568
EP 573
DI 10.1080/13697137.2016.1238452
PG 6
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA ED8DJ
UT WOS:000389101900011
PM 27736245
DA 2025-06-11
ER

PT J
AU Srikanthan, K
   Shapiro, JI
   Sodhi, K
AF Srikanthan, Krithika
   Shapiro, Joseph I.
   Sodhi, Komal
TI The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Obesity
   and Cardiovascular Disease
SO MOLECULES
LA English
DT Review
DE Na/K-ATPase; oxidative stress; pNaKtide; obesity; cardiovascular disease
ID NA+/K+-ATPASE; ADIPOSE-TISSUE; DIFFERENT SENSITIVITIES; METABOLIC
   SYNDROME; OXIDANT STRESS; SRC KINASE; K-ATPASE; C-SRC; ACTIVATION;
   MECHANISM
AB Na/K-ATPase has been extensively studied for its ion pumping function, but, in the past several decades, has been identified as a scaffolding and signaling protein. Initially it was found that cardiotonic steroids (CTS) mediate signal transduction through the Na/K-ATPase and result in the generation of reactive oxygen species (ROS), which are also capable of initiating the signal cascade. However, in recent years, this Na/K-ATPase/ROS amplification loop has demonstrated significance in oxidative stress related disease states, including obesity, atherosclerosis, heart failure, uremic cardiomyopathy, and hypertension. The discovery of this novel oxidative stress signaling pathway, holds significant therapeutic potential for the aforementioned conditions and others that are rooted in ROS.
C1 [Srikanthan, Krithika; Shapiro, Joseph I.] Marshall Univ, Joan C Edwards Sch Med, Dept Med, Huntington, WV 25701 USA.
   [Sodhi, Komal] Marshall Univ, Joan C Edwards Sch Med, Dept Surg, Huntington, WV 25701 USA.
C3 Marshall University; Marshall University
RP Sodhi, K (corresponding author), Marshall Univ, Joan C Edwards Sch Med, Dept Surg, Huntington, WV 25701 USA.
EM srikanthan.krithika@gmail.com; shapiroj@marshall.edu; sodhi@marshall.edu
RI Stefanadis, Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454
FU NIH [HL109015, HL071556, HL105649]; Brickstreet Foundation; Huntington
   Foundation Inc.
FX This work was supported by NIH grants HL109015, HL071556, HL105649, the
   Brickstreet Foundation, and the Huntington Foundation Inc.
CR Abe J, 1997, J BIOL CHEM, V272, P20389, DOI 10.1074/jbc.272.33.20389
   Bibert S, 2011, J BIOL CHEM, V286, P18562, DOI 10.1074/jbc.M110.184101
   Bogdanova A, 2016, FRONT PHYSIOL, V7, DOI 10.3389/fphys.2016.00314
   Bonomini F, 2008, HISTOL HISTOPATHOL, V23, P381, DOI 10.14670/HH-23.381
   Burgess A, 2010, HYPERTENSION, V56, P1124, DOI 10.1161/HYPERTENSIONAHA.110.151423
   Burkard C, 2015, J VIROL, V89, P4434, DOI 10.1128/JVI.03274-14
   Cheung JY, 2007, ANN NY ACAD SCI, V1099, P119, DOI 10.1196/annals.1387.004
   Clifford RJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0084306
   Crujeiras AB, 2013, FREE RADICAL RES, V47, P243, DOI 10.3109/10715762.2013.772604
   De Biase L, 2003, THROMB HAEMOSTASIS, V90, P317, DOI 10.1160/TH03-02-0105
   De Marchi E, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/564961
   De Pauw A, 2009, AM J PATHOL, V175, P927, DOI 10.2353/ajpath.2009.081155
   Figtree GA, 2009, CIRC RES, V105, P185, DOI 10.1161/CIRCRESAHA.109.199547
   Fruchart JC, 2004, CIRCULATION, V109, P15, DOI 10.1161/01.CIR.0000131513.33892.5b
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gable ME, 2014, BIOCHEM BIOPH RES CO, V446, P1151, DOI 10.1016/j.bbrc.2014.03.071
   Garvin JL, 2003, ACTA PHYSIOL SCAND, V179, P225, DOI 10.1046/j.0001-6772.2003.01203.x
   Gill PS, 2006, ANTIOXID REDOX SIGN, V8, P1597, DOI 10.1089/ars.2006.8.1597
   Go AS, 2013, CIRCULATION, V127, P143, DOI [10.1161/CIR.0b013e318282ab8f, 10.1161/CIR.0000000000000366]
   Haller ST, 2012, AM J HYPERTENS, V25, P690, DOI 10.1038/ajh.2012.17
   Harrison D, 2003, AM J CARDIOL, V91, p7A
   Himmelfarb J, 2002, KIDNEY INT, V62, P1524, DOI 10.1046/j.1523-1755.2002.00600.x
   HUANG WH, 1992, INT J BIOCHEM, V24, P621
   HUANG WH, 1994, BBA-BIOMEMBRANES, V1190, P108, DOI 10.1016/0005-2736(94)90039-6
   Kennedy D, 2003, J AM SOC NEPHROL, V14, P90, DOI 10.1097/01.ASN.0000037403.95126.03
   Kennedy DJ, 2008, AM J PHYSIOL-RENAL, V294, pF450, DOI 10.1152/ajprenal.00472.2007
   Kennedy DJ, 2006, AM J PHYSIOL-HEART C, V291, pH3003, DOI 10.1152/ajpheart.00603.2006
   Kennedy DJ, 2006, HYPERTENSION, V47, P488, DOI 10.1161/01.HYP.0000202594.82271.92
   KIM MS, 1987, AM J PHYSIOL, V252, pH252, DOI 10.1152/ajpheart.1987.252.2.H252
   Kotova O, 2006, J BIOL CHEM, V281, P20085, DOI 10.1074/jbc.M601577200
   Kraker AJ, 2000, BIOCHEM PHARMACOL, V60, P885, DOI 10.1016/S0006-2952(00)00405-6
   Kuroda J, 2010, P NATL ACAD SCI USA, V107, P15565, DOI 10.1073/pnas.1002178107
   Lafontan M, 2014, DIABETES METAB, V40, P16, DOI 10.1016/j.diabet.2013.08.002
   Lakshmi SVV, 2009, INDIAN J BIOCHEM BIO, V46, P421
   Le Lay S, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/908539
   Li M, 2008, DIABETES, V57, P1526, DOI 10.2337/db07-1764
   Li ZC, 2011, J BIOL CHEM, V286, P32394, DOI 10.1074/jbc.M110.207597
   Li ZC, 2009, J BIOL CHEM, V284, P21066, DOI 10.1074/jbc.M109.013821
   Li ZC, 2009, PFLUG ARCH EUR J PHY, V457, P635, DOI 10.1007/s00424-008-0470-0
   Liang M, 2006, J BIOL CHEM, V281, P19709, DOI 10.1074/jbc.M512240200
   Liu J, 2012, INT J NEPHROL, V2012, DOI 10.1155/2012/381320
   Liu LJ, 2011, BIOCHEMISTRY-US, V50, P8664, DOI 10.1021/bi2009008
   Liu LJ, 2003, AM J PHYSIOL-CELL PH, V284, pC1550, DOI 10.1152/ajpcell.00555.2002
   Morel P, 1998, NEUROCHEM INT, V33, P531, DOI 10.1016/S0197-0186(98)00062-X
   Petrushanko IY, 2012, J BIOL CHEM, V287, P32195, DOI 10.1074/jbc.M112.391094
   Saavedra WF, 2002, CIRC RES, V90, P297, DOI 10.1161/hh0302.104531
   Schiffrin EL, 2003, J AM COLL CARDIOL, V42, P911, DOI 10.1016/S0735-1097(03)00845-3
   Schwinger RHG, 2003, CARDIOVASC RES, V57, P913, DOI 10.1016/S0008-6363(02)00767-8
   Siems WG, 1996, FREE RADICAL BIO MED, V20, P215, DOI 10.1016/0891-5849(95)02041-1
   Sodhi K, 2015, SCI ADV, V1, DOI 10.1126/sciadv.1500781
   Srikanthan K, 2016, INT J MED SCI, V13, P25, DOI 10.7150/ijms.13800
   Talior I, 2003, AM J PHYSIOL-ENDOC M, V285, pE295, DOI 10.1152/ajpendo.00044.2003
   Thévenod F, 1999, FASEB J, V13, P1751, DOI 10.1096/fasebj.13.13.1751
   Tian J, 2006, MOL BIOL CELL, V17, P317, DOI 10.1091/mbc.E05-08-0735
   Tian J, 2009, HYPERTENSION, V54, P1313, DOI 10.1161/HYPERTENSIONAHA.109.140038
   Touyz RM, 2011, HYPERTENS RES, V34, P5, DOI 10.1038/hr.2010.201
   Urakawa H, 2003, J CLIN ENDOCR METAB, V88, P4673, DOI 10.1210/jc.2003-030202
   Vincent HK, 2006, INT J OBESITY, V30, P400, DOI 10.1038/sj.ijo.0803177
   Vogiatzi G, 2009, HELL J CARDIOL, V50, P402
   Wang HJ, 2004, J BIOL CHEM, V279, P17250, DOI 10.1074/jbc.M313239200
   Weigand KM, 2012, BBA-BIOMEMBRANES, V1818, P1269, DOI 10.1016/j.bbamem.2012.01.015
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Wilcox CS, 2005, AM J PHYSIOL-REG I, V289, pR913, DOI 10.1152/ajpregu.00250.2005
   Wilson-Fritch L, 2004, J CLIN INVEST, V114, P1281, DOI 10.1172/JCI200421752
   Wong CM, 2008, CIRC RES, V102, P310, DOI 10.1161/CIRCRESAHA.107.159814
   XIE Z, 1995, BIOCHEM BIOPH RES CO, V207, P155, DOI 10.1006/bbrc.1995.1166
   XIE ZJ, 1990, J MOL CELL CARDIOL, V22, P911, DOI 10.1016/0022-2828(90)90122-I
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yamaguchi Taro, 2014, PLoS One, V9, pe102133, DOI 10.1371/journal.pone.0102133
   Yan YL, 2016, CURR OPIN PHARMACOL, V27, P43, DOI 10.1016/j.coph.2016.01.009
   Yan YL, 2013, J BIOL CHEM, V288, P34249, DOI 10.1074/jbc.M113.461020
   Ye QQ, 2011, J BIOL CHEM, V286, P6225, DOI 10.1074/jbc.M110.202051
   Yosef E, 2016, J BIOL CHEM, V291, P11736, DOI 10.1074/jbc.M116.721084
   ZOLOTARJOVA N, 1994, BBA-BIOMEMBRANES, V1192, P125, DOI 10.1016/0005-2736(94)90152-X
NR 74
TC 65
Z9 70
U1 1
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD SEP
PY 2016
VL 21
IS 9
AR 1172
DI 10.3390/molecules21091172
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA DY9UE
UT WOS:000385479800069
PM 27598118
OA Green Published, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Zhang, QY
   Dong, GZ
   Zhu, XY
   Cao, Y
   Zhang, XY
AF Zhang, Qiaoyang
   Dong, Guanzhong
   Zhu, Xuanyan
   Cao, Yin
   Zhang, Xiangyang
TI Elevated thyroid stimulating hormone and metabolic syndrome risk in
   patients with first-episode and drug-naïve major depressive disorder: a
   large-scale cross-sectional study
SO BMC PSYCHIATRY
LA English
DT Article
DE Metabolic syndrome; Depression; Thyroid; TSH
ID FREE THYROXINE CONCENTRATION
AB Background Metabolic syndrome (MetS) is common in major depressive disorder (MDD), but its relationship with thyroid hormones remains unclear. We aimed to examine the association of thyroid hormones and MetS in first-episode drug-na & iuml;ve (FEDN) MDD patients. Methods We recruited 1718 unmedicated MDD patients in this cross-sectional study. MetS was defined based on the 2004 Chinese Diabetes Society Criteria. Serum thyroid hormones including free thyroxine (FT4), free triiodothyronine (FT3), thyroid-stimulating hormone (TSH), thyroid peroxidase antibodies (TPOAb), and anti-thyroglobulin (TGAb) were examined. We used the logistic regression model to determine risk factors for MetS and examined the performance of the regression model by using the Area Under the Curve (AUC). In addition, we performed the trend test to test whether the results were robust. Results The prevalence of MetS in unmedicated MDD patients was 34.4%. MDD patients with MetS had higher levels of serum TSH, TGAb, and TPOAb (all P < 0.001). Concurrently, serum TSH levels were independent risk factors for MetS in MDD patients (OR:1.49, 95%CI: 1.40-1.58), which could also distinguish MDD patients with and without MetS (AUC was 0.77). Additionally, in the trend test, the results also indicated a similar trend when TSH was used as a categorical variable (P for trend < 0.001). Conclusions This study suggests that TSH levels were independent risk factors for MetS in FEDN MDD patients (OR:1.49). The examination of thyroid function may contribute to the early detection of MetS.
C1 [Zhang, Qiaoyang; Dong, Guanzhong; Zhu, Xuanyan; Cao, Yin] Nanjing Med Univ, Dept Psychol, Affiliated Changzhou Second Peoples Hosp, Changzhou, Jiangsu, Peoples R China.
   [Cao, Yin] Nanjing Med Univ, Changzhou Med Ctr, Nanjing, Jiangsu, Peoples R China.
   [Zhang, Xiangyang] Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
   [Zhang, Xiangyang] Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China.
C3 Nanjing Medical University; Nanjing Medical University; Chinese Academy
   of Sciences; Institute of Psychology, CAS; Chinese Academy of Sciences;
   University of Chinese Academy of Sciences, CAS
RP Cao, Y (corresponding author), Nanjing Med Univ, Dept Psychol, Affiliated Changzhou Second Peoples Hosp, Changzhou, Jiangsu, Peoples R China.; Cao, Y (corresponding author), Nanjing Med Univ, Changzhou Med Ctr, Nanjing, Jiangsu, Peoples R China.; Zhang, XY (corresponding author), Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.; Zhang, XY (corresponding author), Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China.
EM czeyxlk@163.com; zhangxy@psych.ac.cn
RI Zhang, Xiangyang/ABC-7380-2022
OI , cao yin/0000-0001-6549-525X; Zhang, Xiangyang/0000-0003-3326-382X
FU Science and Technology Development Program of Nanjing Medical University
FX Not applicable.
CR Agaba David Collins, 2019, Biomed Res Int, V2019, P1096201, DOI 10.1155/2019/1096201
   [Anonymous], 2004, CHIN J DIAB, V12, P156, DOI 10.3321/j.issn:1006-6187.2004.03.002
   Bernardo M, 2021, ADV THER, V38, P2491, DOI 10.1007/s12325-021-01689-8
   Chan KL, 2019, PHYSIOLOGY, V34, P123, DOI 10.1152/physiol.00047.2018
   Corruble E, 2015, WORLD PSYCHIATRY, V14, P366, DOI 10.1002/wps.20260
   Dominguez LJ, 2016, CURR OPIN CLIN NUTR, V19, P5, DOI 10.1097/MCO.0000000000000243
   Ferrannini E, 2017, AM J PHYSIOL-ENDOC M, V312, pE429, DOI 10.1152/ajpendo.00464.2016
   Friedrich M J, 2017, JAMA, V317, P1517, DOI 10.1001/jama.2017.3826
   Gramaglia C, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00621
   Gutch M, 2017, BIOMED J, V40, P147, DOI 10.1016/j.bj.2016.12.006
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   He JJ, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.661160
   Hiles SA, 2016, DEPRESS ANXIETY, V33, P754, DOI 10.1002/da.22512
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Iwen KA, 2013, EUR THYROID J, V2, P83, DOI 10.1159/000351249
   KAY SR, 1987, SCHIZOPHRENIA BULL, V13, P261, DOI 10.1093/schbul/13.2.261
   Kim HJ, 2021, EUR J ENDOCRINOL, V185, P707, DOI 10.1530/EJE-21-0634
   Kim HJ, 2017, EUR J ENDOCRINOL, V176, P443, DOI [10.1530/eje-16-0734, 10.1530/EJE-16-0734]
   Kim MD, 2020, J AFFECT DISORDERS, V264, P494, DOI 10.1016/j.jad.2019.11.080
   Lan Y, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0196012
   Li XH, 2016, BIOMED RES INT, V2016, DOI 10.1155/2016/9241278
   Liang SR, 2022, CHINESE MED J-PEKING, V135, P350, DOI 10.1097/CM9.0000000000001553
   Mazereel V, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.573479
   Mehran L, 2017, THYROID, V27, P886, DOI 10.1089/thy.2016.0557
   Mehran L, 2014, THYROID, V24, P1566, DOI 10.1089/thy.2014.0103
   Moreira FP, 2019, PSYCHIAT RES, V271, P306, DOI 10.1016/j.psychres.2018.08.009
   North BJ, 2012, CIRC RES, V110, P1097, DOI 10.1161/CIRCRESAHA.111.246876
   Pucci G, 2017, PHARMACOL RES, V120, P34, DOI 10.1016/j.phrs.2017.03.008
   Qiu WX, 2021, FRONT NEUROSCI-SWITZ, V15, DOI 10.3389/fnins.2021.728810
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Takahashi A, 2020, J ATHEROSCLER THROMB, V27, P1010, DOI 10.5551/jat.52225
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Yang WQ, 2023, EUR ARCH PSY CLIN N, V273, P191, DOI 10.1007/s00406-022-01457-x
   Zhang M, 2021, TRANSL PSYCHIAT, V11, DOI 10.1038/s41398-021-01759-z
NR 34
TC 1
Z9 1
U1 1
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD MAY 21
PY 2024
VL 24
IS 1
AR 380
DI 10.1186/s12888-024-05847-4
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA RP6J5
UT WOS:001228901200006
PM 38773550
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tsai, SW
   Chan, YC
   Liang, F
   Hsu, CY
   Lee, IT
AF Tsai, Sen-Wei
   Chan, Yin-Ching
   Liang, Francois
   Hsu, Chiann-Yi
   Lee, I-Te
TI Brain-derived neurotrophic factor correlated with muscle strength in
   subjects undergoing stationary bicycle exercise training
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Article
DE Brain-derived neurotrophic factor; Body weight; Bicycle exercise;
   Metabolic syndrome; Muscle strength
ID METABOLIC SYNDROME; SKELETAL-MUSCLE; BODY-WEIGHT; FOOD-INTAKE; BDNF;
   DEPRESSION; PROTEIN; PLASMA; SERUM; RISK
AB Aims: Several central nervous disorders are associated with metabolic syndrome (MetS) and type 2 diabetes. Reduction in brain-derived neurotrophic factor (BDNF) is involved in the mechanism of central nervous dysfunction. BDNF is up-regulated after exercise, but it is not known whether increased BDNF is related to increases in muscle strength.
   Methods: In the present study, subjects with MetS or type 2 diabetes were enrolled in an exercise program. All participants underwent an indoor bicycle exercise program for twelve weeks. Serum BDNF was determined after overnight fasting. Muscle strength was assessed by extension of the dominant lower extremity.
   Results: A total of 33 subjects were enrolled in this study. The body mass index did not change significantly (from 30.4 +/- 6.0 to 30.2 +/- 5.8 kg/m(2), P = 0.436), but serum BDNF increased significantly (from 17.1 +/- 9.1 to 24.2 +/- 10.7 ng/mL, P < 0.001) after the study. The exercise-associated BDNF was significantly correlated with the increased strength in lower-extremity extension test (r = 0.54, P = 0.001). Using multivariate regression analysis, muscle-strength increment, but not body-weight change, was an independent factor for serum BDNF (95% CI = 0.009-0.044, P = 0.005).
   Conclusions: After a twelve-week program of stationary bicycle exercise, serum BDNF concentration increased, and this change was positively correlated with muscle strength of lower-extremity extension, but not body weight. (Trial registration: NCT02268292, ClinicalTrials.gov) (C) 2015 Elsevier Inc. All rights reserved.
C1 [Tsai, Sen-Wei] Buddhist Tzu Chi Med Fdn, Taichung Tzu Chi Hosp, Dept Phys Med & Rehabil, Taichung 404, Taiwan.
   [Tsai, Sen-Wei] Tzu Chi Univ, Sch Med, Hualien 970, Taiwan.
   [Tsai, Sen-Wei] Natl Taichung Univ Sci & Technol, Ctr Gen Educ, Taichung 404, Taiwan.
   [Tsai, Sen-Wei] Taichung Vet Gen Hosp, Dept Phys Med & Rehabil, Taichung 407, Taiwan.
   [Chan, Yin-Ching] Providence Univ, Dept Food & Nutr, Taichung 433, Taiwan.
   [Liang, Francois] Cycling & Hlth Tech Ind R&D Ctr, Taichung 407, Taiwan.
   [Hsu, Chiann-Yi] Taichung Vet Gen Hosp, Dept Med Res, Taichung 407, Taiwan.
   [Lee, I-Te] Taichung Vet Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, Taichung 407, Taiwan.
   [Lee, I-Te] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan.
   [Lee, I-Te] Chung Shan Med Univ, Sch Med, Taichung 402, Taiwan.
C3 Buddhist Tzu Chi General Hospital; Taichung Tzu Chi Hospital; Tzu Chi
   University; National Taichung University of Science & Technology;
   Taichung Veterans General Hospital; Providence University - Taiwan;
   Taichung Veterans General Hospital; Taichung Veterans General Hospital;
   National Yang Ming Chiao Tung University; Chung Shan Medical University
RP Lee, IT (corresponding author), 1650 Taiwan Blvd Sect 4, Taichung 407, Taiwan.
EM itlee@vghtc.gov.tw
OI Lee, I-Te/0000-0003-2665-3635; Chan, Yin Ching/0000-0001-9602-0775
FU Cycling & Health Tech Industry RD Center; Taichung Veterans General
   Hospital, Taichung, Taiwan [103DHA0500405]
FX The work was supported by grants from the Cycling & Health Tech Industry
   R&D Center, and the Taichung Veterans General Hospital (103DHA0500405),
   Taichung, Taiwan. The statistical analysis was performed by
   Biostatistics Task Force of Taichung Veterans General Hospital,
   Taichung, Taiwan, R.O.C.
CR [Anonymous], 2012, DIABETES CARE, V35, pS11, DOI [10.2337/dc35-S011, 10.2337/dc12-s004]
   [Anonymous], MOL PSYCHIAT
   Beltrán-Sánchez H, 2013, J AM COLL CARDIOL, V62, P697, DOI 10.1016/j.jacc.2013.05.064
   Berchtold NC, 2005, NEUROSCIENCE, V133, P853, DOI 10.1016/j.neuroscience.2005.03.026
   Cho HC, 2012, NEUROSCI LETT, V519, P78, DOI 10.1016/j.neulet.2012.05.025
   Dupont-Versteegden EE, 2004, MUSCLE NERVE, V29, P73, DOI 10.1002/mus.10511
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hittel DS, 2010, MED SCI SPORT EXER, V42, P2023, DOI 10.1249/MSS.0b013e3181e0b9a8
   Jindal RD, 2010, SCHIZOPHR RES, V119, P47, DOI 10.1016/j.schres.2009.12.035
   Karczewska-Kupczewska M, 2011, CLIN BIOCHEM, V44, P817, DOI 10.1016/j.clinbiochem.2011.05.008
   Knaepen K, 2010, SPORTS MED, V40, P765, DOI 10.2165/11534530-000000000-00000
   Krabbe KS, 2009, J AM GERIATR SOC, V57, P1447, DOI 10.1111/j.1532-5415.2009.02345.x
   Kwon Hwi Ryun, 2010, Korean Diabetes J, V34, P101, DOI 10.4093/kdj.2010.34.2.101
   Kwon Hwi Ryun, 2010, Korean Diabetes J, V34, P23, DOI 10.4093/kdj.2010.34.1.23
   Lebrun B, 2006, AUTON NEUROSCI-BASIC, V126, P30, DOI 10.1016/j.autneu.2006.02.027
   Lee IT, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-18
   Lee IT, 2012, CLIN CHIM ACTA, V413, P944, DOI 10.1016/j.cca.2012.02.013
   Levinger I, 2008, MED SCI SPORT EXER, V40, P535, DOI [10.1249/mss.0b013e31815dd057, 10.1249/MSS.0b013e31815dd057]
   Lewin GR, 1996, ANNU REV NEUROSCI, V19, P289, DOI 10.1146/annurev.ne.19.030196.001445
   Liu M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0066233
   Matthews VB, 2009, DIABETOLOGIA, V52, P1409, DOI 10.1007/s00125-009-1364-1
   McPherron AC, 1997, NATURE, V387, P83, DOI 10.1038/387083a0
   Mezuk B, 2013, J PSYCHOSOM RES, V75, P511, DOI 10.1016/j.jpsychores.2013.09.008
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Nakagawa T, 2000, DIABETES, V49, P436, DOI 10.2337/diabetes.49.3.436
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pan WH, 1998, NEUROPHARMACOLOGY, V37, P1553, DOI 10.1016/S0028-3908(98)00141-5
   Papanastasiou E, 2013, THER ADV PSYCHOPHARM, V3, P33, DOI 10.1177/2045125312464385
   Pedersen BK, 2009, EXP PHYSIOL, V94, P1153, DOI 10.1113/expphysiol.2009.048561
   Pereira DS, 2013, ARCH PHYS MED REHAB, V94, P1443, DOI 10.1016/j.apmr.2013.03.029
   Pratesi A, 2013, CLIN CASES MINER BON, V10, P11, DOI 10.11138/ccmbm/2013.10.1.011
   Raschke S, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/320724
   Rizos EN, 2008, PROG NEURO-PSYCHOPH, V32, P1308, DOI 10.1016/j.pnpbp.2008.04.007
   Sattar N, 2003, CIRCULATION, V108, P414, DOI 10.1161/01.CIR.0000080897.52664.94
   Sunagawa K., 2012, C P ANN INT C IEEE E, P6764
   Suttajit S, 2013, NEUROPSYCH DIS TREAT, V9, P941, DOI 10.2147/NDT.S47450
   Swift DL, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0042785
   Toriya M, 2010, J NEUROENDOCRINOL, V22, P987, DOI 10.1111/j.1365-2826.2010.02039.x
   Wu RH, 2011, GENET MOL RES, V10, P3914, DOI 10.4238/2011.October.21.7
   Wu SK, 2006, AM J PHYS MED REHAB, V85, P711, DOI 10.1097/01.phm.0000228597.64057.66
   Yeh CJ, 2011, ASIA PAC J CLIN NUTR, V20, P292
   Zimmet P, 2005, J ATHEROSCLER THROMB, V12, P295, DOI 10.5551/jat.12.295
   Zoladz JA, 2008, J PHYSIOL PHARMACOL, V59, P119
NR 43
TC 24
Z9 27
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD APR
PY 2015
VL 29
IS 3
BP 367
EP 371
DI 10.1016/j.jdiacomp.2015.01.014
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CE8TN
UT WOS:000352117100009
PM 25682570
DA 2025-06-11
ER

PT J
AU Alemohammad, ZB
   Sadeghniiat-Haghighi, K
   Mehraban, M
   Fazlipanah, P
   Rahimi-Golkhandan, A
AF Alemohammad, Zahra Banafsheh
   Sadeghniiat-Haghighi, Khosro
   Mehraban, Mohammad
   Fazlipanah, Parisa
   Rahimi-Golkhandan, Ania
TI The effects of CPAP therapy on metabolic profile and subjective sleep
   parameters in patients with OSA: a prospective trial study
SO SLEEP SCIENCE
LA English
DT Article
DE Sleep; Apnea; Metabolic Syndrome; Continuous Positive Airway Pressure
ID POSITIVE AIRWAY PRESSURE; DAYTIME SLEEPINESS; APNEA; EPIDEMIOLOGY;
   DEFINITION; INSOMNIA
AB Objective: Several studies confirmed a positive association between obstructive sleep apnea (OSA) and metabolic syndrome. Continuous positive airway pressure (CPAP) is the main treatment for patients with moderate and severe OSA. CPAP therapy in adults with OSA results in reduction in sleepiness, blood pressure and improvement of metabolic profile. In this study, we aimed to evaluate the effects of CPAP therapy on various components of metabolic syndrome and subjective sleep parameters in patients with OSA. Material and Methods: In this prospective trial study, 28 patients with moderate and severe OSA enrolled. Patients were asked to fill out the validated Persian version of questionnaires including Epworth sleepiness scale, insomnia severity index, STOP-BANG and Beck depression inventory - II, before and after treatment with CPAP. Weight and blood pressure were recorded before and after treatment. Only 14 patients agreed to blood sampling before and after CPAP therapy (at least 3 months of treatment). Fasting blood samples were analyzed for measuring the levels of FBS (fasting blood sugar), TG (triglyceride), total cholesterol, HDL, LDL, AST, and ALT. Results: Diastolic blood pressure, ISI and STOP-BANG score significantly decreased after treatment (p-value: 0.008, 0.022 and 0.004, respectively). FBS and TG levels decreased after treatment, but only TG levels had significant difference (p-value: 0.46 and 0.016, respectively). Discussion: CPAP therapy had positive effects on diastolic blood pressure, TG levels and ISI score. More studies with larger sample size and longer follow-up periods are warranted to investigate the effects of CPAP therapy on blood pressure, and metabolic parameters.
C1 [Alemohammad, Zahra Banafsheh; Sadeghniiat-Haghighi, Khosro; Mehraban, Mohammad; Fazlipanah, Parisa; Rahimi-Golkhandan, Ania] Univ Tehran Med Sci, Baharloo Hosp, Occupat Sleep Res Ctr, Tehran, Iran.
C3 Tehran University of Medical Sciences
RP Rahimi-Golkhandan, A (corresponding author), Univ Tehran Med Sci, Baharloo Hosp, Occupat Sleep Res Ctr, Tehran, Iran.
EM aniarahimi.g@gmail.com
RI Adel-Mehraban, Mohammad Sadegh/ABD-8813-2021; Alemohammad, Zahra
   Banafsheh/ABG-3882-2021
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Asgari Abdolah, 2019, Tanaffos, V18, P126
   Battan G, 2016, J CLIN DIAGN RES, V10, pOC14, DOI 10.7860/JCDR/2016/23800.8876
   Buchanan P., 2011, PRINCIPLES PRACTICE, P1233
   Cho YW, 2018, J CLIN SLEEP MED, V14, P409, DOI 10.5664/jcsm.6988
   Çuhadaroglu Ç, 2009, LUNG, V187, P75, DOI 10.1007/s00408-008-9131-5
   Dadfar M, 2016, SCIENTIFICA, V2016, DOI 10.1155/2016/8196463
   Dawson A, 2008, J CLIN SLEEP MED, V4, P538
   Gaines J, 2018, SLEEP MED REV, V42, P211, DOI 10.1016/j.smrv.2018.08.009
   Giles TL, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001106.pub2
   Grundy SM, 2004, ARTERIOSCL THROM VAS, V24, pE13, DOI 10.1161/01.ATV.0000111245.75752.C6
   Habukawa M, 2010, SLEEP MED, V11, P552, DOI 10.1016/j.sleep.2010.02.007
   Haghighi KS, 2013, SLEEP BREATH, V17, P419, DOI 10.1007/s11325-012-0646-x
   Khajeh-Mehrizi A, 2016, J Sleep Sci, V1, P23
   Kohler M, 2009, RESPIRATION, V78, P141, DOI 10.1159/000170785
   Kushida CA, 2008, J CLIN SLEEP MED, V4, P157
   Leger D, 2012, SLEEP MED REV, V16, P455, DOI 10.1016/j.smrv.2011.10.001
   Martínez-García MA, 2013, JAMA-J AM MED ASSOC, V310, P2407, DOI 10.1001/jama.2013.281250
   McCullough AJ, 2011, J DIGEST DIS, V12, P333, DOI 10.1111/j.1751-2980.2010.00469.x
   Nadeem R, 2014, J CLIN SLEEP MED, V10, P1295, DOI 10.5664/jcsm.4282
   Pan WH, 2008, ASIA PAC J CLIN NUTR, V17, P37
   Patil SP, 2019, J CLIN SLEEP MED, V15, P301, DOI 10.5664/jcsm.7638
   Redenius R, 2008, J CLIN SLEEP MED, V4, P205
   Sadasivam K, 2015, J CLIN DIAGN RES, V9, pCC7, DOI 10.7860/JCDR/2015/13301.5859
   Sadeghniiat-Haghighi K, 2015, QUAL LIFE RES, V24, P2025, DOI 10.1007/s11136-015-0923-9
   Sadeghniiat-Haghighi K, 2014, QUAL LIFE RES, V23, P533, DOI 10.1007/s11136-013-0489-3
   Venkatnarayan K, 2021, SLEEP BREATH, V25, P1351, DOI 10.1007/s11325-020-02237-4
   Wilcox I, 1998, THORAX, V53, pS25
   Won CHJ, 2020, SLEEP, V43, DOI 10.1093/sleep/zsz274
   Xu SY, 2015, BMC PULM MED, V15, DOI 10.1186/s12890-015-0102-3
   YOUNG T, 1993, NEW ENGL J MED, V328, P1230, DOI 10.1056/NEJM199304293281704
NR 32
TC 2
Z9 3
U1 1
U2 2
PU BRAZILIAN ASSOC SLEEP
PI SAO PAULO
PA RUA DR DIOGO FARIA, 508, VILA CLEMENTINO, SAO PAULO, SP 04037-001,
   BRAZIL
SN 1984-0659
EI 1984-0063
J9 SLEEP SCI
JI Sleep Sci.
PY 2022
VL 15
IS 2
BP 195
EP 199
DI 10.5935/1984-0063.20220041
PG 5
WC Clinical Neurology
WE Emerging Sources Citation Index (ESCI)
SC Neurosciences & Neurology
GA 1Y9FG
UT WOS:000808441900009
PM 35755912
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Choi, WJ
   Shin, D
AF Choi, Woo Jeong
   Shin, Dayeon
TI Interactions between red and processed meat consumption and APOA5
   gene variants associated with the incidence of metabolic syndrome in
   Korean adults
SO GENES AND NUTRITION
LA English
DT Article
DE APOA5; Metabolic syndrome; Single nucleotide polymorphism (SNP);
   Genome-wide association study (GWAS); Red and processed meat; Korean
   Genome and Epidemiology Study (KoGES)
ID CORONARY-HEART-DISEASE; APOLIPOPROTEIN A-V; RISK; MORTALITY; HEALTH
AB Background Metabolic syndrome (MetS) is characterized by the coexistence of disorders such as diabetes, hypertension, hyperlipidemia, and obesity and is affected by genetic factors. Previous genome-wide association studies (GWAS) suggested that APOA5 gene variants were significantly associated with MetS and its components. Dietary factors such as red and processed meat consumption can cause chronic diseases, including hypertension, diabetes, and vascular depression. The aim of this study was to investigate the modulation of the incidence of MetS by the interaction between APOA5 rs662799 polymorphism and red and processed meat consumption. Methods In this prospective cohort study, 3266 participants were collected from the Korea Association REsource (KARE) cohort of the Korean Genome and Epidemiology Study (KoGES) from 2001 to 2016. APOA5 rs662799 polymorphism was extracted by GWAS using the Korean Chip. Red and processed meat consumption data were assessed using a semi-quantitative food frequency questionnaire. Results The incidence of MetS in carriers of the minor G allele of rs662799 (AG + GG) and the third tertile of red and processed meat consumption (serving/day) was higher than those with the major allele of rs662799 (AA) and the first tertile of red and processed meat consumption (HR 1.70, 95% CI 1.30-2.22, p interaction = 0.002). Conclusions An association between the presence of the minor alleles of rs662799 and high red and processed meat consumption and the incidence of MetS was observed in Korean adults.
C1 [Choi, Woo Jeong; Shin, Dayeon] Inha Univ, Dept Food & Nutr, 100 Inha Ro, Incheon 22212, South Korea.
C3 Inha University
RP Shin, D (corresponding author), Inha Univ, Dept Food & Nutr, 100 Inha Ro, Incheon 22212, South Korea.
EM dyshin@inha.ac.kr
RI Shin, Dayeon/GMX-2004-2022
OI Shin, Dayeon/0000-0003-0828-184X
FU National Research Foundation of Korea (NRF) - Korean government (MSIT)
   [2020R1G1A1004940]
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korean government (MSIT) (Grant No.
   2020R1G1A1004940).
CR Azadbakht L, 2009, J NUTR, V139, P335, DOI 10.3945/jn.108.096297
   Bang Soyoun, 2019, [Journal of Korea Academia-Industrial cooperation Society, 한국산학기술학회논문지], V20, P662, DOI 10.5762/KAIS.2019.20.2.662
   Bears A, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-31695-w
   Chien KL, 2008, CLIN CHIM ACTA, V390, P56, DOI 10.1016/j.cca.2007.12.014
   Dionne I, 1999, INT J OBESITY, V23, P312, DOI 10.1038/sj.ijo.0800820
   Domarkiene I, 2013, BALK J MED GENET, V16, P17, DOI 10.2478/bjmg-2013-0026
   Domínguez-Reyes T, 2015, LIPIDS HEALTH DIS, V14, DOI 10.1186/s12944-015-0112-4
   Fall T, 2014, MOL CELL ENDOCRINOL, V382, P740, DOI 10.1016/j.mce.2012.08.018
   Huang LN, 2020, BIOMED ENVIRON SCI, V33, P19, DOI 10.3967/bes2020.003
   Kim Da-Mee, 2021, Korean Journal of Community Nutrition, V26, P37, DOI 10.5720/kjcn.2021.26.1.37
   Kim SA, 2021, NUTR METAB CARDIOVAS, V31, P1714, DOI 10.1016/j.numecd.2021.02.008
   Kim Y, 2017, INT J EPIDEMIOL, V46, DOI 10.1093/ije/dyv316
   고하영, 2015, [Journal of the Korean Society of Food Science and Nutrition, 한국식품영양과학회지], V44, P1028
   Koochakpoor G, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0092-z
   Korean Statistics, 2019, GUID NAT HLTH SCREEN
   Kwon YJ, 2018, CLIN NUTR, V37, P746, DOI 10.1016/j.clnu.2017.06.022
   Lee Y-S., 2020, Korean J Health Promotion, V20, P116, DOI [10.15384/kjhp.2020.20.3.116, DOI 10.15384/KJHP.2020.20.3.116]
   Li D, 2005, ASIA PAC J CLIN NUTR, V14, P113
   Lin E, 2016, SCI REP-UK, V6, DOI 10.1038/srep36830
   Link JC, 2017, ANNU REV NUTR, V37, P225, DOI 10.1146/annurev-nutr-071816-064827
   Maász A, 2007, PATHOL ONCOL RES, V13, P243, DOI 10.1007/BF02893505
   McAfee AJ, 2010, MEAT SCI, V84, P1, DOI 10.1016/j.meatsci.2009.08.029
   Mega JL, 2015, LANCET, V385, P2264, DOI 10.1016/S0140-6736(14)61730-X
   Moon S, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-37832-9
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Ng TP, 2016, JAMA NEUROL, V73, P456, DOI 10.1001/jamaneurol.2015.4899
   Nilsson SK, 2008, J BIOL CHEM, V283, P25920, DOI 10.1074/jbc.M802721200
   Nilsson SK, 2011, ATHEROSCLEROSIS, V219, P15, DOI 10.1016/j.atherosclerosis.2011.07.019
   나대웅, 2010, [Journal of Agricultural Medicine&Community Health, 농촌의학.지역보건], V35, P383
   Seneff S., 2009, APOE-4: The Clue to Why Low Fat Diet and Statins may Cause Alzheimers
   Sindelar J.J., 2011, Am Meat Sci Assoc White Pap Ser, V3, P1
   Sinha R, 2009, ARCH INTERN MED, V169, P562, DOI 10.1001/archinternmed.2009.6
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Voors-Pette C, 2001, ATHEROSCLEROSIS, V157, P481, DOI 10.1016/S0021-9150(00)00752-8
   Wahrmund-Wyle Jennifer L., 2000, Journal of Food Composition and Analysis, V13, P243, DOI 10.1006/jfca.2000.0896
   Xu CX, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0056216
   Yamada Y, 2007, ATHEROSCLEROSIS, V191, P298, DOI 10.1016/j.atherosclerosis.2006.05.035
   Ye KH, 2020, IEEE INT C BIOINFORM, P1403, DOI 10.1109/BIBM49941.2020.9313373
   Yeo Min Ju, 2016, [Journal of Environmental Impact Assessment, 환경영향평가], V25, P280, DOI 10.14249/eia.2016.25.4.280
   You YY, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2017-020016
NR 40
TC 3
Z9 4
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1555-8932
EI 1865-3499
J9 GENES NUTR
JI Genes Nutr.
PD DEC
PY 2022
VL 17
IS 1
AR 5
DI 10.1186/s12263-022-00707-w
PG 14
WC Genetics & Heredity; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Nutrition & Dietetics
GA 0T9QX
UT WOS:000787296800001
PM 35468744
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Endo, Y
   Tabara, Y
   Kawaguchi, T
   Onoufriadis, A
   McGrath, JA
   Matsuda, F
   Kabashima, K
AF Endo, Yuichiro
   Tabara, Yasuharu
   Kawaguchi, Takahisa
   Onoufriadis, Alexandros
   McGrath, John A.
   Matsuda, Fumihiko
   Kabashima, Kenji
CA Nagahama Study Grp
TI Metabolic syndrome and comorbidities in patients with psoriasis: a
   community-based case-control study from the Nagahama cohort in Japan
SO EUROPEAN JOURNAL OF DERMATOLOGY
LA English
DT Article
DE Community-based cohort; comorbidities; Japan; metabolic syndrome (MetS);
   psoriasis
ID OBSTRUCTIVE PULMONARY-DISEASE; ATOPIC-DERMATITIS; PREVALENCE;
   ONYCHOMYCOSIS; EPIDEMIOLOGY; METAANALYSIS; ASSOCIATION; DEPRESSION;
   ONSET
AB Background Psoriasis is reported to be associated with systemic diseases, such as metabolic syndrome (MetS), which is related to high blood pressure, hyperglycaemia, obesity and dyslipidaemia. However, clinical factors associated with psoriasis in the general population have not been fully elucidated. Objectives To explore the clinical factors associated with psoriasis by analysing a dataset of community-based cohort studies Materials & Methods The study participants consisted of 9,183 apparently healthy community residents in Japan (mean age: 64.5 +/- 10.7 years). The clinical parameters used in this study were obtained from a baseline investigation performed between 2008 and 2010. The history of psoriasis was queried using a structured questionnaire Results A total of 335 participants (3.6%) had a history of psoriasis. The psoriasis group was older (64.5 +/- 10.7 vs 57.9 +/- 12.3 years; p < 0.001) and mostly male (43.9 vs 33.0 %, p < 0.001) compared to the non-psoriasis group. Based on univariate analysis, the prevalence of MetS was higher in the psoriasis group (19.1 vs 13.6%, odds ratio = 1.50, p = 0.004), although this association disappeared after adjustment for age and sex. Similar results were observed based on the analysis of each MetS component. Other factors associated with psoriasis were history of tinea pedis (age-and sex-adjusted odds ratio = 5.27), gout (1.97), chronic obstructive pulmonary disease (5.83), reflux oesophagitis (1.72) and depressive symptoms (1.57). After further adjustment for potential covariates, the associations with these factors remained significant. Conclusion Several chronic conditions associated with psoriasis in the general population were identified
C1 [Endo, Yuichiro; Kabashima, Kenji] Kyoto Univ, Dept Dermatol, Kyoto, Japan.
   [Endo, Yuichiro; Onoufriadis, Alexandros; McGrath, John A.] Kings Coll London, St Johns Inst Dermatol, Sch Basic & Med Biosci, London, England.
   [Tabara, Yasuharu; Kawaguchi, Takahisa; Matsuda, Fumihiko] Kyoto Univ, Ctr Genom Med, Kyoto, Japan.
C3 Kyoto University; University of London; King's College London; Kyoto
   University
RP Endo, Y (corresponding author), Kyoto Univ, Dept Dermatol, Kyoto, Japan.; Endo, Y (corresponding author), Kings Coll London, St Johns Inst Dermatol, Sch Basic & Med Biosci, London, England.
EM endo@kuhp.kyoto-u.ac.jp
RI McGrath, John/N-3529-2019; Kabashima, Kenji/G-2521-2014; McGrath,
   John/D-6824-2012
OI Onoufriadis, Alexandros/0000-0001-5026-0431; McGrath,
   John/0000-0002-3708-9964
FU Ministry of Education, Culture, Sports, Science and Technology in Japan;
   Centre of Innovation Programme from Japan Science and Technology Agency;
   Global University Project from Japan Science and Technology Agency;
   Japan Agency for Medical Research and Development (AMED); Grants-in-Aid
   for Scientific Research [21H04850] Funding Source: KAKEN
FX this study was supported by the following grants: University Grants and
   Grant-in-Aid for Scientific Research from the Ministry of Education,
   Culture, Sports, Science and Technology in Japan; The Centre of
   Innovation Programme and the Global University Project from Japan
   Science and Technology Agency; and The Practical Research Project for
   Rare/Intractable Diseases and Comprehensive Research on Ageing and
   Health Science Research Grants for Dementia R&D from the Japan Agency
   for Medical Research and Development (AMED).
CR Ahmadi A, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0118998
   Al Mutairi N, 2018, DERMATOL THER, V31, DOI 10.1111/dth.12566
   [Anonymous], 2005, Nippon Naika Gakkai Zasshi, V94
   Armstrong AW, 2014, BRIT J DERMATOL, V170, P304, DOI 10.1111/bjd.12670
   Azzawi M, 1999, CARDIOVASC RES, V43, P850, DOI 10.1016/S0008-6363(99)00138-8
   Botelho KP, 2020, METAB SYNDR RELAT D, V18, P154, DOI 10.1089/met.2019.0092
   Carrillo-Meléndrez H, 2016, SKIN APPENDAGE DISOR, V2, P22, DOI 10.1159/000446444
   Conrad C, 2018, CLIN REV ALLERG IMMU, V54, P102, DOI 10.1007/s12016-018-8668-1
   Damevska K, 2013, J DTSCH DERMATOL GES, V11, P1169, DOI 10.1111/ddg.12193
   Danielsen K, 2015, BRIT J DERMATOL, V172, P419, DOI 10.1111/bjd.13288
   Danielsen K, 2013, BRIT J DERMATOL, V168, P1303, DOI 10.1111/bjd.12230
   Dreiher J, 2008, BRIT J DERMATOL, V159, P956, DOI 10.1111/j.1365-2133.2008.08749.x
   Duvetorp A, 2021, DERMATOLOGY, V237, P595, DOI 10.1159/000509732
   Eder L, 2019, ARTHRIT CARE RES, V71, P1084, DOI 10.1002/acr.23743
   FOX RH, 1965, BMJ-BRIT MED J, V1, P619, DOI 10.1136/bmj.1.5435.619
   Gavrielov-Yusim N, 2014, J EPIDEMIOL COMMUN H, V68, P283, DOI 10.1136/jech-2013-202744
   Gisondi P, 2007, BRIT J DERMATOL, V157, P68, DOI 10.1111/j.1365-2133.2007.07986.x
   Gupta MA, 1998, BRIT J DERMATOL, V139, P846
   Gupta MA, 2003, AM J CLIN DERMATOL, V4, P833, DOI 10.2165/00128071-200304120-00003
   HayRania A, 2014, J DERMATOL SCI, V75, P150, DOI 10.1016/j.jdermsci.2014.04.013
   Hu SCS, 2019, ACTA DERM-VENEREOL, V99, P530, DOI 10.2340/00015555-3145
   Jensen P, 2016, ACTA DERM-VENEREOL, V96, P39, DOI 10.2340/00015555-2183
   Kadowaki S, 2018, METAB SYNDR RELAT D, V16, P166, DOI 10.1089/met.2017.0132
   Kamal R, 2015, TOXICOL REP, V2, P1064, DOI 10.1016/j.toxrep.2015.07.013
   Kamiya K, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20184347
   Kubota K, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2014-006450
   Langan SM, 2012, J INVEST DERMATOL, V132, P556, DOI 10.1038/jid.2011.365
   Leibovici V, 2014, MYCOSES, V57, P754, DOI 10.1111/myc.12227
   Li X, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0145221
   Mallbris L, 2006, J AM ACAD DERMATOL, V54, P614, DOI 10.1016/j.jaad.2005.11.1079
   Rodríguez-Zúñiga MJM, 2017, J AM ACAD DERMATOL, V77, P657, DOI 10.1016/j.jaad.2017.04.1133
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   Miller IM, 2015, J EUR ACAD DERMATOL, V29, P490, DOI 10.1111/jdv.12595
   Parisi R, 2013, J INVEST DERMATOL, V133, P377, DOI 10.1038/jid.2012.339
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Richter JE, 2018, GASTROENTEROLOGY, V154, P267, DOI 10.1053/j.gastro.2017.07.045
   Riley GF, 2009, MED CARE, V47, pS51, DOI 10.1097/MLR.0b013e31819c95aa
   Singh S, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0181039
   Snekvik I, 2019, BRIT J DERMATOL, V180, P94, DOI 10.1111/bjd.16885
   Springate DA, 2017, BRIT J DERMATOL, V176, P650, DOI 10.1111/bjd.15021
   Statistics of Japan, 2021, LAB FORC SURV
   Stefanadi EC, 2018, DIABETOL METAB SYNDR, V10, DOI 10.1186/s13098-018-0311-z
   Terui T., 2014, RINSHOIYAKU, V30, P279
   Tsentemeidou A, 2017, MYCOSES, V60, P830, DOI 10.1111/myc.12681
   Verma S, 2015, INT J DERMATOL, V54, pE192, DOI 10.1111/ijd.12734
   Wang GS, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0156243
   Yeung H, 2013, JAMA DERMATOL, V149, P1173, DOI 10.1001/jamadermatol.2013.5015
   Zander N, 2017, ARCH DERMATOL RES, V309, P349, DOI 10.1007/s00403-017-1741-4
   Zisova L, 2012, MYCOSES, V55, P143, DOI 10.1111/j.1439-0507.2011.02053.x
   Zohar A, 2016, CLIN RHEUMATOL, V35, P2679, DOI 10.1007/s10067-016-3374-y
NR 50
TC 1
Z9 1
U1 0
U2 4
PU JLE
PI ARCUEIL
PA 30, RUE BERTHOLLET, BATIMENT A, 94110 ARCUEIL, ?, FRANCE
SN 1167-1122
EI 1952-4013
J9 EUR J DERMATOL
JI Eur. J. Dermatol.
PD JAN
PY 2022
VL 32
IS 1
BP 86
EP 93
DI 10.1684/ejd.2022.4231
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 1X5KU
UT WOS:000807493300010
PM 35514103
DA 2025-06-11
ER

PT J
AU Przepiera-Bedzak, H
   Fischer, K
   Brzosko, M
AF Przepiera-Bedzak, Hanna
   Fischer, Katarzyna
   Brzosko, Marek
TI Serum interleukin-23 protects, whereas methotrexate treatment stimulates
   selected components of the metabolic syndrome in patients with SAPHO
   syndrome
SO ARCHIVES OF MEDICAL SCIENCE
LA English
DT Article
DE interleukin-23; lipid profile; metabolic syndrome; methotrexate; SAPHO
ID SINGLE-CENTER; PSORIATIC-ARTHRITIS; OSTEITIS SYNDROME; HYPEROSTOSIS;
   PUSTULOSIS; ACNE; PREVALENCE; SYNOVITIS; DISEASE; COHORT
AB Introduction: The aim of the study was to evaluate the impact of disease activity, selected serum cytokines, and therapy on metabolic syndrome (MetS) components in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome.
   Material and methods: We studied 46 SAPHO patients (40 women, 6 men). We recorded age, sex, disease duration, arthritis localization, type of skin changes, bone scintigraphy results, comorbidities, BASDAI, VAS, and treatment. We measured erythrocyte sedimentation rate, C-reactive protein, lipid profile, serum IL-6, IL-18, IL-23, endothelin-1, vascular endothelial growth factor, and epidermal growth factor (EGF).
   Results: 97.8% of patients had sternoclavicular joint arthritis, 91.3% of patients palmoplantar pustulosis. In 65.2% of SAPHO patients skin changes and arthritis started simultaneously. Apart from non-steroidal anti-inflammatory drugs, patients were treated with methotrexate (41.3%), sulfasalazine (41.3%), and antibiotics (39.1%). 19.5% of patients met MetS criteria. Serum IL-23 correlated positively with total cholesterol (TC; p = 0.02) and high-density lipoprotein cholesterol (HDL-C) (p = 0.01) in the SAPHO group. There was a negative correlation between HDL-C and BASDAI (p = 0.02). Patients treated with methotrexate had higher triglyceride (p = 0.01) and low-density lipoprotein cholesterol (LDL-C) (p = 0.01) levels. There was a negative correlation between TC and EGF (p = 0.03). Increased prevalence of autoimmune diseases and depression was observed in SAPHO patients.
   Conclusions: Serum IL-23 protects, whereas methotrexate treatment stimulates selected components of the MetS in patients with SAPHO syndrome.
C1 [Przepiera-Bedzak, Hanna; Brzosko, Marek] Pomeranian Med Univ, Dept Rheumatol Internal Med & Geriatr, 1 Unii Lubelskiej St, PL-71252 Szczecin, Poland.
   [Fischer, Katarzyna] Pomeranian Med Univ, Independent Lab Rheumat Diagnost, Szczecin, Poland.
C3 Pomeranian Medical University; Pomeranian Medical University
RP Przepiera-Bedzak, H (corresponding author), Pomeranian Med Univ, Dept Rheumatol Internal Med & Geriatr, 1 Unii Lubelskiej St, PL-71252 Szczecin, Poland.
EM hannapb@pum.edu.pl
RI Fischer, Katarzyna/AAL-1282-2020; Przepiera-Bedzak, Hanna/A-5443-2015
FU National Science Centre in Poland [DEC-2011/03/B/NZ5/04192]
FX This work was supported by a grant from the National Science Centre in
   Poland (DEC-2011/03/B/NZ5/04192).
CR Aljuhani F, 2015, J RHEUMATOL, V42, P329, DOI 10.3899/jrheum.140342
   Assmann G, 2009, ARTHRITIS RES THER, V11, DOI 10.1186/ar2812
   Blankenberg S, 2003, CIRCULATION, V108, P2453, DOI 10.1161/01.CIR.0000099509.76044.A2
   CHAMOT AM, 1987, REV RHUM, V54, P187
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Colina M, 2014, MOD RHEUMATOL, V24, P697, DOI 10.3109/14397595.2013.874760
   Colina M, 2009, ARTHRIT RHEUM-ARTHR, V61, P813, DOI 10.1002/art.24540
   Costa L, 2014, CLIN RHEUMATOL, V33, P833, DOI 10.1007/s10067-013-2369-1
   Ellulu MS, 2017, ARCH MED SCI, V13, P851, DOI 10.5114/aoms.2016.58928
   GARRETT S, 1994, J RHEUMATOL, V21, P2286
   Govoni M, 2009, AUTOIMMUN REV, V8, P256, DOI 10.1016/j.autrev.2008.07.030
   Hayem G, 1999, SEMIN ARTHRITIS RHEU, V29, P159, DOI 10.1016/S0049-0172(99)80027-4
   Hurtado-Nedelec M, 2008, RHEUMATOLOGY, V47, P1160, DOI 10.1093/rheumatology/ken185
   KAHN MF, 1994, BAILLIERE CLIN RHEUM, V8, P333, DOI 10.1016/S0950-3579(94)80022-7
   Lang JK, 2014, STEM CELL TRANSL MED, V3, P549, DOI 10.5966/sctm.2013-0205
   Lewinson RT, 2017, J INVEST DERMATOL, V137, P828, DOI 10.1016/j.jid.2016.11.032
   Li C, 2016, RHEUMATOLOGY, V55, P1023, DOI 10.1093/rheumatology/kew015
   Linke R, 2010, AM J ROENTGENOL, V194, pW329, DOI 10.2214/AJR.09.3288
   Marques C, 2013, CELL BIOL TOXICOL, V29, P293, DOI 10.1007/s10565-013-9255-0
   Mok CC, 2011, ARTHRIT CARE RES, V63, P195, DOI 10.1002/acr.20363
   Navarro-Millán I, 2013, ARTHRITIS RHEUM-US, V65, P1430, DOI 10.1002/art.37916
   Nitzsche EU, 2011, HANDCHIR MIKROCHIR P, V43, P20, DOI 10.1055/s-0030-1267975
   Przepiera-Bedzak H., 2012, Postepy Nauk Medycznych, V25, P89
   Przepiera-Bedzak H, 2016, ACTA DERMATOVENER CR, V24, P305
   Przepiera-Bedzak H, 2016, MEDIAT INFLAMM, V2016, DOI 10.1155/2016/7617954
   Przepiera-Bedzak H, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17081255
   Przepiera-Bedzak H, 2015, MEDIAT INFLAMM, V2015, DOI 10.1155/2015/785705
   Przepiera-Bedzak H, 2013, POL ARCH MED WEWN, V123, P297, DOI 10.20452/pamw.1772
   Przepiera-Bedzak Hanna, 2006, Pol Arch Med Wewn, V116, P1172
   Przepiera-Bedzak Hanna, 2002, Pol Arch Med Wewn, V107, P59
   Raychaudhuri SK, 2010, METAB SYNDR RELAT D, V8, P331, DOI 10.1089/met.2009.0124
   Sabugo F, 2008, CLIN RHEUMATOL, V27, P533, DOI 10.1007/s10067-007-0767-y
   Sallés M, 2011, CLIN RHEUMATOL, V30, P245, DOI 10.1007/s10067-010-1560-x
   Schilling F, 2000, Z RHEUMATOL, V59, P1, DOI 10.1007/s003930050001
   Singh AK, 2011, CLIN RHEUMATOL, V30, P771, DOI 10.1007/s10067-010-1646-5
   Valkema PA, 2017, ORPHANET J RARE DIS, V12, DOI 10.1186/s13023-017-0573-9
   Wu JJ, 2017, J EUR ACAD DERMATOL, V31, P1168, DOI 10.1111/jdv.14175
NR 37
TC 7
Z9 7
U1 0
U2 1
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1734-1922
EI 1896-9151
J9 ARCH MED SCI
JI Arch. Med. Sci.
PY 2021
VL 17
IS 1
BP 120
EP 126
DI 10.5114/aoms.2018.76953
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA QD5TT
UT WOS:000615581000016
PM 33488864
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Weerarathna, TP
   Lekamwasam, S
   Kodikara, I
   Wasana, KGP
   Fonseka, L
AF Weerarathna, Thilak Priyantha
   Lekamwasam, Sarath
   Kodikara, Iroshani
   Wasana, Keddegoda Gamage Piyumi
   Fonseka, Lakmal
TI Control of cardiometabolic risk factors and their association with
   carotid intima media thickness among patients with type 2 diabetes
   mellitus-single center experience in a developing country
SO TURKISH JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE Atherosclerotic cardiovascular diseases; cardiometabolic risk factors;
   carotid intima-media thickness; type 2 diabetes mellitus
ID FATTY LIVER-DISEASE; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; GLYCEMIC
   CONTROL; GUT MICROBIOTA; SOUTH ASIANS; EVENTS; INDIVIDUALS; CHOLESTEROL;
   MECHANISMS
AB Background/aim: Type 2 diabetes mellitus (T2DM) is closely associated with atherosclerotic cardiovascular diseases (ASCVD). The objective of this study was to describe the degree of ASCVD risk factor control and their association with carotid intima-media thickness (CIMT) in T2DM patients followed up at a diabetes clinic in Southern, Sri Lanka. Materials and methods: A crosssectional study was conducted to examine the association between CIMT and nonalcoholic fatty liver disease (NAFLD)in 300 T2DM patients. Both CIMT and its associations with modifiable cardiometabolic risk factors were examined using ultrasonography. The recommended optimal targets for risk factors were defined as glycated hemoglobin (HbA 1C ) < 7 %, absence of NAFLD, albumin-to-creatinine ratio (ACR) < 30 mg, triglyceride (TG) < 150 mg/dL, low -density lipoprotein cholesterol (LDL-C) < 100 mg/dL, high -density lipoprotein cholesterol (HDL-C) in men > 40 and in women > 50 mg/dL, systolic blood pressure (SBP) < 130 mmHg, and diastolic blood pressure (DBP) < 80 mmHg. Results: SBP, DBP, LDL-C, TG, HDL-C, HbA 1C , and ACR were optimally controlled in 59.3%, 75.0%, 46.7%, 84.3%, 46.0%, 33.0%, and 18.7% of patients, respectively. Notably, nearly half of the study subjects did not have NAFLD. Only three patients (1%) had achieved all therapeutic targets. There were statistically significant differences in CIMT between optimally controlled TG and suboptimally controlled TG group (p = 0.027) and between the groups with and without NAFLD (p = 0.045) when adjusted for age and duration of diabetes. CIMT showed significant and positive associations with LDL-C (p = 0.024), TG (p = 0.026), and NAFLD (p = 0.005). Among these, the presence of NAFLD had the highest odds of having higher CIMT when compared to LDL-C and TG. Conclusion: The majority of patients have not achieved the recommended targets for ASCVD risk factors and are at high risk of ASCVD. It is therefore necessary to identify the reasons for not achieving the treatment targets in order to reduce the ASCVD burden by controlling LDL-C, TG, and NAFLD.
C1 [Weerarathna, Thilak Priyantha; Lekamwasam, Sarath; Fonseka, Lakmal] Univ Ruhuna, Fac Med, Dept Med, Galle, Sri Lanka.
   [Kodikara, Iroshani] Univ Ruhuna, Fac Med, Dept Anat, Galle, Sri Lanka.
   [Wasana, Keddegoda Gamage Piyumi] Cooperat Hosp, Diabet Ctr, Galle, Sri Lanka.
C3 University Ruhuna; University Ruhuna
RP Weerarathna, TP (corresponding author), Univ Ruhuna, Fac Med, Dept Med, Galle, Sri Lanka.
EM thilak.priyantha@yahoo.com
RI Kodikara, Iroshani/ABC-7143-2021
FX Acknowledgment/disclaimers We would like to express our gratitude to the
   nursing and supporting staff of the University Medical Clinic at the
   Teaching Hospital Karapitiya, Southern, Sri Lanka, for their support
   during the study.
CR Abdul-Ghani M, 2017, DIABETES CARE, V40, P813, DOI 10.2337/dc16-2736
   Abdullah SM, 2018, CIRCULATION, V138, P2315, DOI 10.1161/CIRCULATIONAHA.118.034273
   Alizargar J, 2018, BMC CARDIOVASC DISOR, V18, DOI 10.1186/s12872-018-0752-1
   Amer Diabet Assoc Professional Pra, 2022, DIABETES CARE, V45, pS125, DOI 10.2337/dc22-S009
   Arab JP, 2018, ANNU REV PATHOL-MECH, V13, P321, DOI 10.1146/annurev-pathol-020117-043617
   Arambewela MH, 2018, J DIABETES RES, V2018, DOI 10.1155/2018/4504287
   Aron-Wisnewsky J, 2013, CLIN MICROBIOL INFEC, V19, P338, DOI 10.1111/1469-0691.12140
   Bilen O, 2016, WORLD J CARDIOL, V8, P247, DOI 10.4330/wjc.v8.i3.247
   Caussy C, 2021, CURR DIABETES REP, V21, DOI 10.1007/s11892-021-01383-7
   Chen R, 2015, MED SCI MONITOR, V21, P1440, DOI 10.12659/MSM.892246
   Chistiakov DA, 2015, FRONT MICROBIOL, V6, DOI 10.3389/fmicb.2015.00671
   Chubb SAP, 2022, ACTA DIABETOL, V59, P1615, DOI 10.1007/s00592-022-01969-x
   Darabian S, 2013, CURR ATHEROSCLER REP, V15, DOI 10.1007/s11883-012-0306-4
   Das AK, 2021, DIABET METAB SYND OB, V14, P2693, DOI 10.2147/DMSO.S294842
   Dodani S, 2008, VASC HEALTH RISK MAN, V4, P953, DOI 10.2147/VHRM.S2915
   El Hadi H, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9030567
   Francque SM, 2016, J HEPATOL, V65, P425, DOI 10.1016/j.jhep.2016.04.005
   Gaede P, 2003, NEW ENGL J MED, V348, P383, DOI 10.1056/NEJMoa021778
   Gaidhane S, 2020, J FAM MED PRIM CARE, V9, P2033, DOI 10.4103/jfmpc.jfmpc_1192_19
   Galatou E, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11061060
   Guo FQ, 2021, EXP CLIN ENDOCR DIAB, V129, P283, DOI 10.1055/a-0865-1754
   Harchaoui KEL, 2009, CURR CARDIOL REV, V5, P216, DOI 10.2174/157340309788970315
   Heidemann BE, 2021, INT J CARDIOL, V322, P251, DOI 10.1016/j.ijcard.2020.08.030
   Henson JB, 2020, ALIMENT PHARM THER, V51, P728, DOI 10.1111/apt.15660
   Huang Y, 2010, J CLIN ENDOCR METAB, V95, P5122, DOI 10.1210/jc.2010-0544
   Ichikawa K, 2021, CARDIOVASC DIABETOL, V20, DOI 10.1186/s12933-020-01192-4
   Khunti K, 2018, DIABETES RES CLIN PR, V137, P137, DOI 10.1016/j.diabres.2017.12.004
   Kowall B, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0052590
   Lee CD, 2004, CIRCULATION, V109, P855, DOI 10.1161/01.CIR.0000116389.61864.DE
   Li H, 2021, Association between triglyceride glucose index and carotid atherosclerosis in patients with type 2 diabetes mellitus: a cross-sectional study, DOI [10.21203/rs.3.rs-1078184/v1, DOI 10.21203/RS.3.RS-1078184/V1]
   Makshood M, 2019, CURR CARDIOVASC RISK, V13, DOI 10.1007/s12170-019-0618-9
   Narayan KMV, 2021, ENDOCRIN METAB CLIN, V50, pXVII, DOI 10.1016/j.ecl.2021.06.001
   Polimeni L, 2015, WORLD J HEPATOL, V7, P1325, DOI 10.4254/wjh.v7.i10.1325
   Poznyak A, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21051835
   Pursnani S, 2020, ATHEROSCLEROSIS, V315, P126, DOI 10.1016/j.atherosclerosis.2020.10.007
   Ren L, 2018, J HUM HYPERTENS, V32, P548, DOI 10.1038/s41371-018-0074-x
   Saglietto A, 2021, MINERVA CARDIOL ANGI, V69, P231, DOI 10.23736/S2724-5683.21.05538-9
   Song QR, 2022, FRONT CARDIOVASC MED, V9, DOI 10.3389/fcvm.2022.889597
   Targher G, 2007, DIABETES CARE, V30, P2119, DOI 10.2337/dc07-0349
   Targher G, 2007, DIABETES CARE, V30, P1212, DOI 10.2337/dc06-2247
   Targher G, 2016, J HEPATOL, V65, P589, DOI 10.1016/j.jhep.2016.05.013
   Tariq Z, 2014, LIVER INT, V34, pE180, DOI 10.1111/liv.12523
   Taylor RS, 2020, GASTROENTEROLOGY, V158, P1611, DOI 10.1053/j.gastro.2020.01.043
   van den Hoek AM, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23158229
   Volgman AS, 2018, CIRCULATION, V138, pE1, DOI 10.1161/CIR.0000000000000580
   Wasana KGP, 2022, INT J DIABETES DEV C, V42, P435, DOI 10.1007/s13410-021-00995-9
   Weerarathna TP, 2018, DIABET METAB SYND OB, V11, P409, DOI 10.2147/DMSO.S172485
   Wong ND, 2013, DIABETES VASC DIS RE, V10, P505, DOI 10.1177/1479164113496828
   Yang XY, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.664183
NR 49
TC 0
Z9 0
U1 0
U2 1
PU Tubitak Scientific & Technological Research Council Turkey
PI ANKARA
PA ATATURK BULVARI NO 221, KAVAKLIDERE, TR-06100 ANKARA, TURKIYE
SN 1300-0144
EI 1303-6165
J9 TURK J MED SCI
JI Turk. J. Med. Sci.
PY 2024
VL 54
IS 3
DI 10.55730/1300-0144.5821
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA UT5T0
UT WOS:001250329000008
PM 39050007
OA hybrid
DA 2025-06-11
ER

PT J
AU Chen, J
   Patschan, S
   Goligorsky, MS
AF Chen, Jun
   Patschan, Susann
   Goligorsky, Michael S.
TI Stress-induced premature senescence of endothelial cells
SO JOURNAL OF NEPHROLOGY
LA English
DT Review
DE Endothelium; Macrovasculopathy; Metabolic syndrome; Microvasculopathy;
   Stress induced premature senescence
ID GLYCATION END-PRODUCTS; PLASMINOGEN-ACTIVATOR INHIBITOR; HUMAN-DIPLOID
   FIBROBLASTS; CELLULAR SENESCENCE; OXIDATIVE STRESS; REPLICATIVE
   SENESCENCE; DNA-DAMAGE; DIABETIC COMPLICATIONS; OXIDANT STRESS; GROWTH
   ARREST
AB Stress-induced premature senescence (SIPS):is characterized by cell cycle arrest and curtailed Hayflick limit. Studies support a central role for Rb protein in controlling this process via signaling from the p53 and p16 pathways. Cellular senescence is considered, an., essential contributor to the aging process and has been shown to be an important tumor suppression mechanism. In addition, emerging evidence suggests that. SIPS may be involved in the pathogenesis of chronic human., diseases. Here, focusing on endothelial cells, we discuss recent advances in our understanding of SIPS and the pathways that trigger it, evaluate their correlation with the apoptotic response and examine their links to the development of chronic diseases, with the emphasis on vasculopathy. Emerging novel therapeutic interventions based on recent experimental findings are also reviewed.
C1 New York Med Coll, Renal Res Inst, Dept Med, Valhalla, NY 10595 USA.
   New York Med Coll, Renal Res Inst, Dept Pharmacol, Valhalla, NY 10595 USA.
C3 Renal Research Institute; New York Medical College; New York Medical
   College; Renal Research Institute
RP Goligorsky, MS (corresponding author), New York Med Coll, Renal Res Inst, Dept Med, Valhalla, NY 10595 USA.
EM Michael_goligorsky@nymc.edu
FU NIDDK NIH HHS [DK54602, DK45462, DK52783] Funding Source: Medline
CR Abe A, 2000, ANAL BIOCHEM, V287, P344, DOI 10.1006/abio.2000.4874
   Assmus B, 2003, CIRC RES, V92, P1049, DOI 10.1161/01.RES.0000070067.64040.7C
   Balin AK, 2002, EXP CELL RES, V274, P275, DOI 10.1006/excr.2002.5485
   Balin AK, 2002, FREE RADICAL BIO MED, V32, P257, DOI 10.1016/S0891-5849(01)00807-3
   Baynes JW, 2001, EXP GERONTOL, V36, P1527, DOI 10.1016/S0531-5565(01)00138-3
   Beauséjour CM, 2003, EMBO J, V22, P4212, DOI 10.1093/emboj/cdg417
   Ben-Porath I, 2005, INT J BIOCHEM CELL B, V37, P961, DOI 10.1016/j.biocel.2004.10.013
   Bladier C, 1997, CELL GROWTH DIFFER, V8, P589
   Breitschopf K, 2001, FEBS LETT, V493, P21, DOI 10.1016/S0014-5793(01)02272-4
   Bringold F, 2000, EXP GERONTOL, V35, P317, DOI 10.1016/S0531-5565(00)00083-8
   Brodsky SV, 2004, CIRC RES, V94, P377, DOI 10.1161/01.RES.0000111802.09964.EF
   Brodsky SV, 2003, NEPHRON EXP NEPHROL, V93, pE46, DOI 10.1159/000066653
   Brooke S, 2004, EXP CELL RES, V298, P549, DOI 10.1016/j.yexcr.2004.04.035
   Brookes S, 2002, EMBO J, V21, P2936, DOI 10.1093/emboj/cdf289
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   BROWNLEE M, 1988, NEW ENGL J MED, V318, P1315
   CAMPBELL EEB, 2003, DEV FULL SC, V5, P1
   Campisi J, 1998, J Investig Dermatol Symp Proc, V3, P1
   Campisi J, 2005, CELL, V120, P513, DOI 10.1016/j.cell.2005.02.003
   Chander PN, 2004, J AM SOC NEPHROL, V15, P2391, DOI 10.1097/01.ASN.0000135971.88164.2C
   Chappey O, 1997, EUR J CLIN INVEST, V27, P97, DOI 10.1046/j.1365-2362.1997.710624.x
   Chen J, 2002, CIRC RES, V90, P1290, DOI 10.1161/01.RES.0000022161.42655.98
   CHEN Q, 1994, P NATL ACAD SCI USA, V91, P4130, DOI 10.1073/pnas.91.10.4130
   Chen QM, 2000, ANN NY ACAD SCI, V908, P111
   Chen QM, 2000, BIOCHEM J, V347, P543, DOI 10.1042/0264-6021:3470543
   Chimenti C, 2003, CIRC RES, V93, P604, DOI 10.1161/01.RES.0000093985.76901.AF
   Cho KA, 2003, J BIOL CHEM, V278, P27789, DOI 10.1074/jbc.M208105200
   COMI P, 1995, EXP CELL RES, V219, P304, DOI 10.1006/excr.1995.1232
   Dannenberg JH, 2000, GENE DEV, V14, P3051, DOI 10.1101/gad.847700
   Deng QD, 2004, J BIOL CHEM, V279, P1050, DOI 10.1074/jbc.M308644200
   DIMRI GP, 1995, P NATL ACAD SCI USA, V92, P9363, DOI 10.1073/pnas.92.20.9363
   Fenton M, 2001, ARTERIOSCL THROM VAS, V21, P220, DOI 10.1161/01.ATV.21.2.220
   Ferbeyre G, 2002, MOL CELL BIOL, V22, P3497, DOI 10.1128/MCB.22.10.3497-3508.2002
   Gealekman O, 2004, KIDNEY INT, V66, P2337, DOI 10.1111/j.1523-1755.2004.66035.x
   Gire W, 2004, EMBO J, V23, P2554, DOI 10.1038/sj.emboj.7600259
   Goligorsky MS, 2000, KIDNEY INT, V58, P1360, DOI 10.1046/j.1523-1755.2000.00292.x
   Gorbunova V, 2002, J BIOL CHEM, V277, P38540, DOI 10.1074/jbc.M202671200
   HARLEY CB, 1990, NATURE, V345, P458, DOI 10.1038/345458a0
   HAYFLICK L, 1961, EXP CELL RES, V25, P585, DOI 10.1016/0014-4827(61)90192-6
   Heidland A, 2001, AM J KIDNEY DIS, V38, pS100, DOI 10.1053/ajkd.2001.27414
   Herbig U, 2004, MOL CELL, V14, P501, DOI 10.1016/S1097-2765(04)00256-4
   Hoffmann J, 2001, CIRC RES, V89, P709, DOI 10.1161/hh2001.097796
   Hofmann MA, 1998, DIABETES CARE, V21, P841, DOI 10.2337/diacare.21.5.841
   Horie K, 1997, J CLIN INVEST, V100, P2995, DOI 10.1172/JCI119853
   Ihling C, 1997, ARTERIOSCL THROM VAS, V17, P2218, DOI 10.1161/01.ATV.17.10.2218
   Jacobs JJL, 2004, CURR BIOL, V14, P2302, DOI 10.1016/j.cub.2004.12.025
   Joosten SA, 2003, AM J PATHOL, V162, P1305, DOI 10.1016/S0002-9440(10)63926-0
   Kaneko T, 2001, MUTAT RES-DNA REPAIR, V487, P19, DOI 10.1016/S0921-8777(01)00100-8
   Kiyono T, 1998, NATURE, V396, P84, DOI 10.1038/23962
   KULJU KS, 1995, EXP CELL RES, V217, P336, DOI 10.1006/excr.1995.1095
   Kurz DJ, 2004, J CELL SCI, V117, P2417, DOI 10.1242/jcs.01097
   Kyriakis JM, 2001, PHYSIOL REV, V81, P807, DOI 10.1152/physrev.2001.81.2.807
   Lander HM, 1997, J BIOL CHEM, V272, P17810, DOI 10.1074/jbc.272.28.17810
   Lee L, 1999, J BIOL CHEM, V274, P14662, DOI 10.1074/jbc.274.21.14662
   Liu JP, 1999, FASEB J, V13, P2091, DOI 10.1096/fasebj.13.15.2091
   MacLaren A, 2004, MOL CELL BIOL, V24, P9006, DOI 10.1128/MCB.24.20.9006-9018.2004
   MAIER JAM, 1993, EXP CELL RES, V208, P270, DOI 10.1006/excr.1993.1246
   Masumoto K, 1996, FEBS LETT, V398, P179, DOI 10.1016/S0014-5793(96)01237-9
   Matsushita H, 2001, CIRC RES, V89, P793, DOI 10.1161/hh2101.098443
   Melk A, 2001, J AM SOC NEPHROL, V12, P385, DOI 10.1681/ASN.V122385
   Migliaccio E, 1999, NATURE, V402, P309, DOI 10.1038/46311
   Minamino T, 2004, J MOL CELL CARDIOL, V36, P175, DOI 10.1016/j.yjmcc.2003.11.010
   Minamino T, 2002, CIRCULATION, V105, P1541, DOI 10.1161/01.CIR.0000013836.85741.17
   Naka K, 2004, J BIOL CHEM, V279, P2030, DOI 10.1074/jbc.M309457200
   Nakajima M, 1997, EXP GERONTOL, V32, P685, DOI 10.1016/S0531-5565(97)00089-2
   Napoli C, 2003, P NATL ACAD SCI USA, V100, P2112, DOI 10.1073/pnas.0336359100
   Narita M, 2003, CELL, V113, P703, DOI 10.1016/S0092-8674(03)00401-X
   Nishikawa T, 2000, NATURE, V404, P787, DOI 10.1038/35008121
   Palmero I, 2001, METHOD ENZYMOL, V333, P247
   Rebbaa A, 2003, ONCOGENE, V22, P2805, DOI 10.1038/sj.onc.1206366
   Rincheval V, 2002, BIOCHEM BIOPH RES CO, V298, P282, DOI 10.1016/S0006-291X(02)02454-3
   Rösen P, 2001, DIABETES-METAB RES, V17, P189, DOI 10.1002/dmrr.196
   Sage J, 2000, GENE DEV, V14, P3037, DOI 10.1101/gad.843200
   SATO I, 1993, BIOCHEM BIOPH RES CO, V195, P1070, DOI 10.1006/bbrc.1993.2153
   Schmidt AM, 1999, CIRC RES, V84, P489, DOI 10.1161/01.RES.84.5.489
   Seluanov A, 2001, MOL CELL BIOL, V21, P1552, DOI 10.1128/MCB.21.5.1552-1564.2001
   Unterluggauer H, 2003, EXP GERONTOL, V38, P1149, DOI 10.1016/j.exger.2003.08.007
   van der Loo B, 2000, J EXP MED, V192, P1731, DOI 10.1084/jem.192.12.1731
   Wagner M, 2001, EXP GERONTOL, V36, P1327, DOI 10.1016/S0531-5565(01)00105-X
   Wang WP, 2002, MOL CELL BIOL, V22, P3389, DOI 10.1128/MCB.22.10.3389-3403.2002
   WAUTIER JL, 1994, P NATL ACAD SCI USA, V91, P7742, DOI 10.1073/pnas.91.16.7742
   Wendt T, 2003, J AM SOC NEPHROL, V14, P1383, DOI 10.1097/01.ASN.0000065100.17349.CA
   West MD, 1996, EXP GERONTOL, V31, P175, DOI 10.1016/0531-5565(95)02013-6
   WU JT, 1993, J CLIN LAB ANAL, V7, P252, DOI 10.1002/jcla.1860070503
   Yuan XM, 2002, P NATL ACAD SCI USA, V99, P6286, DOI 10.1073/pnas.092135599
   Zhang H, 2003, P NATL ACAD SCI USA, V100, P3251, DOI 10.1073/pnas.2627983100
   Zhang JL, 2002, MECH AGEING DEV, V123, P613, DOI 10.1016/S0047-6374(01)00412-2
NR 87
TC 25
Z9 28
U1 2
U2 7
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1121-8428
EI 1724-6059
J9 J NEPHROL
JI J. Nephrol.
PD MAY-JUN
PY 2008
VL 21
IS 3
BP 337
EP 344
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 405SO
UT WOS:000263244700010
PM 18587721
DA 2025-06-11
ER

PT J
AU Zarrouki, B
   Soares, AF
   Guichardant, M
   Lagarde, M
   Géloën, A
AF Zarrouki, B.
   Soares, A. F.
   Guichardant, M.
   Lagarde, M.
   Geloen, A.
TI The lipid peroxidation end-product 4-HNE induces COX-2 expression
   through p38MAPK activation in 3T3-L1 adipose cell
SO FEBS LETTERS
LA English
DT Article
DE oxidative stress; 4-hydroxy-2-nonenal; cyclooxygenase; p38MAPK;
   adipocyte; 3T3-L1
ID OXIDATIVE STRESS; METABOLIC SYNDROME; CYCLOOXYGENASE-2; INFLAMMATION;
   ADIPOCYTES; IMPACT; OBESE
AB Oxidative stress and low grade chronic inflammation are increased in accumulating fat. Our objective was to test whether 4-hydroxynonenal (4-HNE), an end-product of lipid peroxidation, affects cyclooxygenases in 3T3-L1 adipose cells. 4-HNE increased COX-2 mRNA and protein expression and p38MAP-kinase phosphorylation in a dose-dependent manner. Pretreatment of 3T3-L1 cells by a selective inhibitor of p38MAPK (PD 169316) abolished 4-HNE and glucose oxidase induced COX-2 expression.
   Our results show that oxidative stress induces COX-2 expression through the production of 4-HNE which activates p38MAP-Kinase, suggesting that 4-HNE links oxidative stress and chronic inflammation through the activation of cyclooxygenase. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
C1 [Zarrouki, B.; Soares, A. F.; Guichardant, M.; Lagarde, M.; Geloen, A.] Inst Natl Sci Appl, INSERM, UMR 870, 11 Ave J Capelle, F-69621 Villeurbanne, France.
   [Zarrouki, B.; Soares, A. F.; Guichardant, M.; Lagarde, M.; Geloen, A.] Univ Lyon, F-69008 Lyon, France.
   [Zarrouki, B.; Soares, A. F.; Guichardant, M.; Lagarde, M.; Geloen, A.] INSERM U870, F-69008 Lyon, France.
   [Zarrouki, B.; Soares, A. F.; Guichardant, M.; Lagarde, M.; Geloen, A.] INRA, U1235, F-69008 Lyon, France.
   [Zarrouki, B.; Soares, A. F.; Guichardant, M.; Lagarde, M.; Geloen, A.] Univ Lyon 1, F-69003 Lyon, France.
   [Zarrouki, B.; Soares, A. F.; Guichardant, M.; Lagarde, M.; Geloen, A.] Hospices Civils Lyon, F-69003 Lyon, France.
C3 Institut National des Sciences Appliquees de Lyon - INSA Lyon; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Institut
   National de la Sante et de la Recherche Medicale (Inserm); INRAE;
   Universite Claude Bernard Lyon 1; Universite Claude Bernard Lyon 1; CHU
   Lyon
RP Géloën, A (corresponding author), Inst Natl Sci Appl, INSERM, UMR 870, 11 Ave J Capelle, F-69621 Villeurbanne, France.
EM alain.geloen@insa-lyon.fr
RI SOARES, ANÍSIO/AAS-6950-2021; GELOEN, Alain/D-6725-2011
OI SOARES, ANISIO FRANCISCO/0000-0003-1493-7964; GELOEN,
   Alain/0000-0001-7921-1254
CR Bacot S, 2003, J LIPID RES, V44, P917, DOI 10.1194/jlr.M200450-JLR200
   ESTERBAUER H, 1991, FREE RADICAL BIO MED, V11, P81, DOI 10.1016/0891-5849(91)90192-6
   Frisard M, 2006, ENDOCRINE, V29, P27, DOI 10.1385/ENDO:29:1:27
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Helmersson J, 2004, CIRCULATION, V109, P1729, DOI 10.1161/01.CIR.0000124718.99562.91
   Holzenberger M, 2003, NATURE, V421, P182, DOI 10.1038/nature01298
   Kakishita H, 2001, LIFE SCI, V69, P689, DOI 10.1016/S0024-3205(01)01166-3
   Kumagai T, 2004, J BIOL CHEM, V279, P48389, DOI 10.1074/jbc.M409935200
   Kumagai T, 2000, BIOCHEM BIOPH RES CO, V273, P437, DOI 10.1006/bbrc.2000.2967
   Kumagai T, 2002, ARCH BIOCHEM BIOPHYS, V397, P240, DOI 10.1006/abbi.2001.2601
   Lee YH, 2005, DIABETOLOGIA, V48, P1776, DOI 10.1007/s00125-005-1867-3
   POLI G, 2003, SIGNAL TRANSDUCTION, P180
   RISTIMAKI A, 1994, J BIOL CHEM, V269, P11769
   Soares AF, 2005, FREE RADICAL BIO MED, V38, P882, DOI 10.1016/j.freeradbiomed.2004.12.010
   Stentz FB, 2004, DIABETES, V53, P2079, DOI 10.2337/diabetes.53.8.2079
   Tsatsanis C, 2006, INT J BIOCHEM CELL B, V38, P1654, DOI 10.1016/j.biocel.2006.03.021
   Valle M, 2005, DIABETES METAB, V31, P55, DOI 10.1016/S1262-3636(07)70167-2
NR 17
TC 59
Z9 66
U1 0
U2 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-5793
EI 1873-3468
J9 FEBS LETT
JI FEBS Lett.
PD MAY 29
PY 2007
VL 581
IS 13
BP 2394
EP 2400
DI 10.1016/j.febslet.2007.04.048
PG 7
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 176LW
UT WOS:000247087600003
PM 17481611
DA 2025-06-11
ER

PT J
AU Demirkol, S
   Balta, S
   Celik, T
   Arslan, Z
   Unlu, M
   Cakar, M
   Kucuk, U
   Demirbas, S
   Iyisoy, A
   Yokusoglu, M
AF Demirkol, Sait
   Balta, Sevket
   Celik, Turgay
   Arslan, Zekeriya
   Unlu, Murat
   Cakar, Mustafa
   Kucuk, Ugur
   Demirbas, Seref
   Iyisoy, Atila
   Yokusoglu, Mehmet
TI Assessment of the relationship between red cell distribution width and
   cardiac syndrome X
SO KARDIOLOGIA POLSKA
LA English
DT Article
DE cardiac syndrome X; red cell distribution width; endothelial dysfunction
ID C-REACTIVE PROTEIN; CHEST-PAIN; INFLAMMATION; DISEASE; ATHEROSCLEROSIS
AB Background: Cardiac syndrome X (CSX) is characterised by angina-like chest pain, a positive stress test, and normal coronary arteries. Increased red cell distribution width (RDW) level may be indicative of an underlying inflammatory state.
   Aim: To investigate RDW level in patients with CSX and compare patients having coronary artery disease (CAD) and normal subjects.
   Methods: 245 subjects (79 patients with CSX, 81 patients with CAD, and 85 controls) were enrolled in the study. The CSX group consisted of patients with anginal chest pain, ischaemia on noninvasive stress test and a normal coronary angiogram. CAD was defined as >= 50% stenosis in at least one coronary artery. The control group was selected from the patients with anginal symptoms but a normal stress test and a normal coronary angiogram. RDW measurements among the three groups were compared.
   Results: Baseline clinical and biochemical characteristics were not different among the three groups. There were no statistically significant differences in RDW levels between the CSX and CAD groups (p = 0.17). RDW measurements in both the CSX and CAD groups were found to be significantly higher than the control group (p < 0.01).
   Conclusions: We discovered that patients with CSX and CAD have significantly higher RDW measurements compared to controls. The relationship between CSX and higher RDW level suggests that endothelial dysfunction may also contribute to the etiopathogenesis of the CSX phenomenon as it does with CAD.
C1 [Demirkol, Sait; Balta, Sevket; Celik, Turgay; Kucuk, Ugur; Iyisoy, Atila; Yokusoglu, Mehmet] Gulhane Mil Med Acad, Sch Med, Dept Cardiol, Etlik, Turkey.
   [Arslan, Zekeriya] Gelibolu Hosp, Dept Cardiol, Canakkale, Turkey.
   [Unlu, Murat] Beytepe Hosp, Dept Cardiol, Ankara, Turkey.
   [Cakar, Mustafa; Demirbas, Seref] Gulhane Mil Med Acad, Sch Med, Dept Internal Med, Etlik, Turkey.
C3 Gulhane Military Medical Academy; Gelibolu State Hospital; Ankara
   Beytepe Murat Erdi Eker State Hospital; Gulhane Military Medical Academy
RP Demirkol, S (corresponding author), Gulhane Mil Med Acad, Dept Cardiol, Tevfik Saglam St, TR-06018 Etlik, Turkey.
EM saitdemirkol@yahoo.com
RI Çakar, Mustafa/Y-1380-2019; Celik, Turgay/I-2981-2019
OI Arslan, Zekeriya/0000-0003-1497-1396; Balta, Sevket/0000-0002-6657-7334;
   Celik, Turgay/0000-0001-8418-0130
CR Al Suwaidi J, 2001, MAYO CLIN P, V76, P22
   Arroyo-Espliguero R, 2003, EUR HEART J, V24, P2006, DOI 10.1016/j.ehj.2003.09.029
   Cavusoglu E, 2010, INT J CARDIOL, V141, P141, DOI 10.1016/j.ijcard.2008.11.187
   Cox ID, 2000, CLIN CARDIOL, V23, P645
   Felker GM, 2007, J AM COLL CARDIOL, V50, P40, DOI 10.1016/j.jacc.2007.02.067
   Fukuta H, 2009, INT HEART J, V50, P301, DOI 10.1536/ihj.50.301
   Lind L, 2003, ATHEROSCLEROSIS, V169, P203, DOI 10.1016/S0021-9150(03)00012-1
   Lippi G, 2009, ARCH PATHOL LAB MED, V133, P628, DOI 10.1043/1543-2165-133.4.628
   Packard RRS, 2008, CLIN CHEM, V54, P24, DOI 10.1373/clinchem.2007.097360
   Panting JR, 2002, NEW ENGL J MED, V346, P1948, DOI 10.1056/NEJMoa012369
   Pierce CN, 2005, PERFUSION-UK, V20, P83, DOI 10.1191/0267659105pf793oa
   Teragawa H, 2004, HEART, V90, P750, DOI 10.1136/hrt.2003.022269
   Tonelli M, 2008, CIRCULATION, V117, P163, DOI 10.1161/CIRCULATIONAHA.107.727545
   Tousoulis D, 2001, CLIN CARDIOL, V24, P301, DOI 10.1002/clc.4960240409
   Uyarel H, 2011, CORONARY ARTERY DIS, V22, P138, DOI 10.1097/MCA.0b013e328342c77b
   Weiss G, 2005, NEW ENGL J MED, V352, P1011, DOI 10.1056/NEJMra041809
   WIEDERMANN JG, 1995, J AM COLL CARDIOL, V25, P1310, DOI 10.1016/0735-1097(94)00556-6
NR 17
TC 38
Z9 42
U1 0
U2 4
PU VIA MEDICA
PI GDANSK
PA UL SWIETOKRZYSKA 73, 80-180 GDANSK, POLAND
SN 0022-9032
J9 KARDIOL POL
JI Kardiol. Pol.
PY 2013
VL 71
IS 5
BP 480
EP 484
DI 10.5603/KP.2013.0094
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 169KM
UT WOS:000320779000007
PM 23788088
OA hybrid
DA 2025-06-11
ER

PT J
AU De Blasio, A
   D'Anneo, A
   Lauricella, M
   Emanuele, S
   Giuliano, M
   Pratelli, G
   Calvaruso, G
   Carlisi, D
AF De Blasio, Anna
   D'Anneo, Antonella
   Lauricella, Marianna
   Emanuele, Sonia
   Giuliano, Michela
   Pratelli, Giovanni
   Calvaruso, Giuseppe
   Carlisi, Daniela
TI The Beneficial Effects of Essential Oils in Anti-Obesity Treatment
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE obesity; metabolic syndrome; essential oils
ID BROWN ADIPOSE-TISSUE; DE-NOVO LIPOGENESIS; GUT MICROBIOTA;
   SALVIA-OFFICINALIS; INSULIN-RESISTANCE; OLFACTORY STIMULATION;
   LIPID-METABOLISM; CUMINUM-CYMINUM; BINDING PROTEIN; MEDICINAL-PLANT
AB Obesity is a complex disease caused by an excessive amount of body fat. Obesity is a medical problem and represents an important risk factor for the development of serious diseases such as insulin resistance, type 2 diabetes, cardiovascular disease, and some types of cancer. Not to be overlooked are the psychological issues that, in obese subjects, turn into very serious pathologies, such as depression, phobias, anxiety, and lack of self-esteem. In addition to modifying one's lifestyle, the reduction of body mass can be promoted by different natural compounds such as essential oils (EOs). EOs are mixtures of aromatic substances produced by many plants, particularly in medicinal and aromatic ones. They are odorous and volatile and contain a mixture of terpenes, alcohols, aldehydes, ketones, and esters. Thanks to the characteristics of the various chemical components present in them, EOs are used in the food, cosmetic, and pharmaceutical fields. Indeed, it has been shown that EOs possess great antibiotic, anti-inflammatory, and antitumor powers. Emerging results also demonstrate the anti-obesity effects of EOs. We have examined the main data obtained in experimental studies and, in this review, we summarize the effect of EOs in obesity and obesity-related metabolic diseases.
C1 [De Blasio, Anna; D'Anneo, Antonella; Giuliano, Michela; Calvaruso, Giuseppe] Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol STEBICE, Lab Biochem, I-90127 Palermo, Italy.
   [Lauricella, Marianna; Emanuele, Sonia; Pratelli, Giovanni; Carlisi, Daniela] Univ Palermo, Inst Biochem, Dept Biomed Neurosci & Adv Diagnost BIND, I-90127 Palermo, Italy.
C3 University of Palermo; University of Palermo
RP Lauricella, M; Carlisi, D (corresponding author), Univ Palermo, Inst Biochem, Dept Biomed Neurosci & Adv Diagnost BIND, I-90127 Palermo, Italy.
EM anna.deblasio@unipa.it; antonella.danneo@unipa.it;
   marianna.lauricella@unipa.it; sonia.emanuele@unipa.it;
   michela.giuliano@unipa.it; giovanni.pratelli@unipa.it;
   giuseppe.calvaruso@unipa.it; daniela.carlisi@unipa.it
RI D’Anneo, Antonella/P-1064-2019; Lauricella, Marianna/ABD-1263-2020
OI CARLISI, Daniela/0000-0002-5833-7904; GIULIANO,
   Michela/0000-0002-5114-6267; D'ANNEO, Antonella/0000-0002-1785-8236; DE
   BLASIO, Anna/0000-0003-2208-0366; Pratelli,
   Giovanni/0000-0002-5294-2564; LAURICELLA, Marianna/0000-0002-0157-3834
CR Abd Rashed A, 2017, J ESSENT OIL RES, V29, P1, DOI 10.1080/10412905.2016.1213668
   Adak A, 2019, CELL MOL LIFE SCI, V76, P473, DOI 10.1007/s00018-018-2943-4
   Al Massadi O, 2019, NEUROPHARMACOLOGY, V148, P131, DOI 10.1016/j.neuropharm.2019.01.001
   Ali-shtayeh MS, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/3834265
   Aminizadeh M, 2020, MOL BIOL REP, V47, P7805, DOI 10.1007/s11033-020-05857-x
   Apovian Caroline M, 2016, Am J Manag Care, V22, ps176
   Arner Peter, 2018, Nestle Nutr Inst Workshop Ser, V89, P37, DOI 10.1159/000486491
   Aziz ZAA, 2018, CURR DRUG METAB, V19, P1100, DOI 10.2174/1389200219666180723144850
   Bäckhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Baker RG, 2011, CELL METAB, V13, P11, DOI 10.1016/j.cmet.2010.12.008
   Bakkali F, 2008, FOOD CHEM TOXICOL, V46, P446, DOI 10.1016/j.fct.2007.09.106
   Balsan GA, 2015, REV ASSOC MED BRAS, V61, P72, DOI 10.1590/1806-9282.61.01.072
   Balusamy SR, 2018, BIOMED PHARMACOTHER, V108, P1835, DOI 10.1016/j.biopha.2018.10.028
   Batubara I, 2015, NUTRIENTS, V7, P1859, DOI 10.3390/nu7031859
   Bays Harold E, 2008, Expert Rev Cardiovasc Ther, V6, P343, DOI 10.1586/14779072.6.3.343
   Behradmanesh S, 2013, J RENAL INJ PREV, V2, P51, DOI 10.12861/jrip.2013.18
   Belgardt BF, 2010, ANN NY ACAD SCI, V1212, P97, DOI 10.1111/j.1749-6632.2010.05799.x
   Belhadj S, 2018, BIOMED PHARMACOTHER, V108, P985, DOI 10.1016/j.biopha.2018.09.108
   Boucher J, 2014, CSH PERSPECT BIOL, V6, DOI 10.1101/cshperspect.a009191
   Broadhurst CL, 2000, J AGR FOOD CHEM, V48, P849, DOI 10.1021/jf9904517
   Camacho S, 2015, SCI REP-UK, V5, DOI 10.1038/srep07919
   Cammisotto PG, 2010, PROG HISTOCHEM CYTO, V45, P143, DOI 10.1016/j.proghi.2010.06.001
   Capurso C, 2012, VASC PHARMACOL, V57, P91, DOI 10.1016/j.vph.2012.05.003
   Carmen GY, 2006, CELL SIGNAL, V18, P401, DOI 10.1016/j.cellsig.2005.08.009
   Chan DC, 2014, BEST PRACT RES CL EN, V28, P369, DOI 10.1016/j.beem.2013.10.001
   Cheng Bing-Ho, 2018, J Tradit Complement Med, V8, P46, DOI 10.1016/j.jtcme.2017.02.002
   Chiasson H, 2001, J ECON ENTOMOL, V94, P167, DOI 10.1603/0022-0493-94.1.167
   Cho S, 2012, J NUTR BIOCHEM, V23, P192, DOI 10.1016/j.jnutbio.2010.11.016
   Chouchani ET, 2019, CELL METAB, V29, P27, DOI 10.1016/j.cmet.2018.11.002
   Christensen S, 2020, J AM ASSOC NURSE PRA, V32, P497, DOI 10.1097/JXX.0000000000000482
   Chung J, 2018, J PERIODONTOL, V89, P1262, DOI 10.1002/JPER.17-0727
   Ciccarelli M, 2013, FRONT PHYSIOL, V4, DOI 10.3389/fphys.2013.00265
   Claussnitzer M, 2015, NEW ENGL J MED, V373, P895, DOI 10.1056/NEJMoa1502214
   Cornier MA, 2008, ENDOCR REV, V29, P777, DOI 10.1210/er.2008-0024
   Derbenev AV, 2016, SEMIN IMMUNOPATHOL, V38, P397, DOI 10.1007/s00281-015-0529-x
   Desjardins EM, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1049-6
   do Nascimento LD, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10070988
   Donado-Pestana CM, 2021, FOOD CHEM, V340, DOI 10.1016/j.foodchem.2020.128169
   Donath MY, 2011, NAT REV IMMUNOL, V11, P98, DOI 10.1038/nri2925
   Duncan RE, 2007, ANNU REV NUTR, V27, P79, DOI 10.1146/annurev.nutr.27.061406.093734
   Emílio-Silva MT, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10101454
   Engin A, 2017, ADV EXP MED BIOL, V960, P1, DOI 10.1007/978-3-319-48382-5_1
   Engin AB, 2017, ADV EXP MED BIOL, V960, P197, DOI 10.1007/978-3-319-48382-5_8
   Fenzl A, 2014, HORM MOL BIOL CLIN I, V19, P25, DOI 10.1515/hmbci-2014-0022
   Friedman JM, 2019, NAT METAB, V1, P754, DOI 10.1038/s42255-019-0095-y
   Furuhashi M, 2016, ARTERIOSCL THROM VAS, V36, P825, DOI 10.1161/ATVBAHA.116.307225
   Gao ZG, 2004, MOL ENDOCRINOL, V18, P2024, DOI 10.1210/me.2003-0383
   Gérard P, 2016, CELL MOL LIFE SCI, V73, P147, DOI 10.1007/s00018-015-2061-5
   Giralt M, 2013, ENDOCRINOLOGY, V154, P2992, DOI 10.1210/en.2013-1403
   Gruzdeva O, 2019, DIABET METAB SYND OB, V12, P191, DOI 10.2147/DMSO.S182406
   Hadi A, 2018, PHYTOTHER RES, V32, P2146, DOI 10.1002/ptr.6162
   Harrison L, 2019, INT J OBESITY, V43, P1305, DOI 10.1038/s41366-018-0221-z
   He P, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9090444
   Heinonen S, 2020, OBES REV, V21, DOI 10.1111/obr.12958
   HELLMER J, 1992, J CLIN ENDOCR METAB, V75, P15, DOI 10.1210/jc.75.1.15
   Hong SJ, 2020, NUTRIENTS, V12, DOI 10.3390/nu12072077
   Hur Myung-haeng, 2006, Taehan Kanho Hakhoe Chi, V36, P236
   Hynes GR, 2001, CURR OPIN LIPIDOL, V12, P321, DOI 10.1097/00041433-200106000-00012
   Ikeda K, 2018, TRENDS ENDOCRIN MET, V29, P191, DOI 10.1016/j.tem.2018.01.001
   Imparl-Radosevich J, 1998, HORM RES, V50, P177, DOI 10.1159/000023270
   Jafari Sahar, 2017, J Tradit Complement Med, V7, P332, DOI 10.1016/j.jtcme.2016.08.004
   Jafari T, 2018, J FUNCT FOODS, V47, P416, DOI 10.1016/j.jff.2018.06.009
   Jiang CY, 2017, ONCOTARGET, V8, P75114, DOI 10.18632/oncotarget.20540
   Jing L, 2013, EUR J PHARMACOL, V715, P46, DOI 10.1016/j.ejphar.2013.06.022
   Sáez-Lara MJ, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17060928
   Jun HJ, 2012, J NUTR, V142, P432, DOI 10.3945/jn.111.152538
   Kalaivani P, 2013, CLIN EXP HYPERTENS, V35, P534, DOI 10.3109/10641963.2013.764887
   Kang NH, 2018, BIOCHIMIE, V151, P1, DOI 10.1016/j.biochi.2018.05.009
   Karimi A, 2020, FRONT PLANT SCI, V11, DOI 10.3389/fpls.2020.00969
   Kaur IP, 2016, CURR PHARM DESIGN, V22, P4160, DOI 10.2174/1381612822666160608115350
   Kaur Navrinder, 2019, Artif Cells Nanomed Biotechnol, V47, P2930, DOI 10.1080/21691401.2019.1641509
   Kaur Y, 2017, OBES REV, V18, P603, DOI 10.1111/obr.12531
   Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2548, DOI 10.1210/jc.2004-0395
   Kim KA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047713
   Klok MD, 2007, OBES REV, V8, P21, DOI 10.1111/j.1467-789X.2006.00270.x
   Koubaa FG, 2021, ENVIRON SCI POLLUT R, V28, P11001, DOI 10.1007/s11356-020-11303-z
   Koubaa-Ghorbel F, 2020, J FOOD BIOCHEM, V44, DOI 10.1111/jfbc.13160
   Lafontan M, 2009, PROG LIPID RES, V48, P275, DOI 10.1016/j.plipres.2009.05.001
   Lai YS, 2016, J AGR FOOD CHEM, V64, P2062, DOI 10.1021/acs.jafc.5b06159
   Lai YS, 2014, J AGR FOOD CHEM, V62, P5897, DOI 10.1021/jf500803c
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Lefranc C, 2018, J ENDOCRINOL, V238, pR143, DOI 10.1530/JOE-18-0163
   Legrand C, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-68013-2
   Leherbauer I, 2020, Z NATURFORSCH C, V75, P205, DOI 10.1515/znc-2020-0007
   Leong W, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.01229
   Leyva-López N, 2017, MOLECULES, V22, DOI 10.3390/molecules22060989
   Li AL, 2020, MICROBIOL IMMUNOL, V64, P23, DOI 10.1111/1348-0421.12749
   Li DH, 2019, BIOSCI BIOTECH BIOCH, V83, P923, DOI 10.1080/09168451.2019.1578640
   Li DH, 2018, BIOCHEM BIOPH RES CO, V505, P991, DOI 10.1016/j.bbrc.2018.10.035
   Lima CF, 2006, BRIT J NUTR, V96, P326, DOI 10.1079/BJN20061832
   Lorençoni MF, 2020, J ETHNOPHARMACOL, V252, DOI 10.1016/j.jep.2020.112562
   Lozupone CA, 2012, NATURE, V489, P220, DOI 10.1038/nature11550
   Luc K, 2019, J PHYSIOL PHARMACOL, V70, P809, DOI 10.26402/jpp.2019.6.01
   Luca T, 2020, CHEM BIODIVERS, V17, DOI 10.1002/cbdv.202000309
   Makris MC, 2017, IN VIVO, V31, P1047, DOI 10.21873/invivo.11168
   Marchesi JR, 2016, GUT, V65, P330, DOI 10.1136/gutjnl-2015-309990
   McMurray RG, 2005, SPORTS MED, V35, P393, DOI 10.2165/00007256-200535050-00003
   Moghrovyan A, 2019, CURR PHARM DESIGN, V25, P1809, DOI 10.2174/1381612825666190702095612
   Mosbah H, 2018, BMC COMPLEM ALTERN M, V18, DOI 10.1186/s12906-018-2145-5
   Mraz M, 2011, J CLIN ENDOCR METAB, V96, pE606, DOI 10.1210/jc.2010-1858
   Musilli C, 2014, BRIT J PHARMACOL, V171, P3476, DOI 10.1111/bph.12697
   Myers MG, 2008, ANNU REV PHYSIOL, V70, P537, DOI 10.1146/annurev.physiol.70.113006.100707
   Nagai K, 2014, AUTON NEUROSCI-BASIC, V185, P29, DOI 10.1016/j.autneu.2014.06.005
   Niijima A, 2003, EXP BIOL MED, V228, P1190, DOI 10.1177/153537020322801014
   Oelkrug R, 2015, J COMP PHYSIOL B, V185, P587, DOI 10.1007/s00360-015-0907-7
   Ozcan L, 2009, CELL METAB, V9, P35, DOI 10.1016/j.cmet.2008.12.004
   Park Anna, 2014, World J Stem Cells, V6, P33, DOI 10.4252/wjsc.v6.i1.33
   Park HK, 2017, KOREAN J INTERN MED, V32, P239, DOI 10.3904/kjim.2016.229
   Parker JA, 2012, NEUROPHARMACOLOGY, V63, P18, DOI 10.1016/j.neuropharm.2012.02.004
   Patel VB, 2017, HEART FAIL REV, V22, P889, DOI 10.1007/s10741-017-9644-1
   Provensi G, 2014, P NATL ACAD SCI USA, V111, P11527, DOI 10.1073/pnas.1322016111
   Puri D, 1999, J Assoc Physicians India, V47, P255
   Puri Dinesh, 1998, Indian Journal of Physiology and Pharmacology, V42, P423
   Regnault-Roger C, 2012, ANNU REV ENTOMOL, V57, P405, DOI 10.1146/annurev-ento-120710-100554
   Ricquier Daniel, 2011, Front Endocrinol (Lausanne), V2, P85, DOI 10.3389/fendo.2011.00085
   Russo A, 2013, FOOD CHEM TOXICOL, V55, P42, DOI 10.1016/j.fct.2012.12.036
   Sae-Lee C, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0147411
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Salehi F, 2020, INT J BIOL MACROMOL, V143, P382, DOI 10.1016/j.ijbiomac.2019.12.058
   Sanchez-Gurmaches J, 2018, CELL METAB, V27, P195, DOI 10.1016/j.cmet.2017.10.008
   Schwartz MW, 2000, NATURE, V404, P661, DOI 10.1038/35007534
   Seidell JC, 2015, ANN NUTR METAB, V66, P7, DOI 10.1159/000375143
   Shaw LM, 2011, CELL CYCLE, V10, P1750, DOI 10.4161/cc.10.11.15824
   Shen J, 2005, NEUROSCI LETT, V380, P289, DOI 10.1016/j.neulet.2005.01.058
   Smith U, 2016, J INTERN MED, V280, P465, DOI 10.1111/joim.12540
   Song ZY, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101383
   Spalletta S, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0206894
   Sun K, 2011, J CLIN INVEST, V121, P2094, DOI 10.1172/JCI45887
   Swamy MK, 2015, MOLECULES, V20, P8521, DOI 10.3390/molecules20058521
   Taghizadeh M, 2015, ANN NUTR METAB, V66, P117, DOI 10.1159/000373896
   Talpur N, 2005, DIABETES OBES METAB, V7, P193, DOI 10.1111/j.1463-1326.2004.00386.x
   Tan CY, 2011, J DIABETES INVEST, V2, P341, DOI 10.1111/j.2040-1124.2011.00158.x
   Tansey JT, 2004, IUBMB LIFE, V56, P379, DOI 10.1080/15216540400009968
   Terada Y, 2019, BIOSCI BIOTECH BIOCH, V83, P1721, DOI 10.1080/09168451.2019.1611405
   Tilg H, 2008, MOL MED, V14, P222, DOI 10.2119/2007-00119.Tilg
   Timper K, 2017, DIS MODEL MECH, V10, P679, DOI 10.1242/dmm.026609
   Vieira AJ, 2018, CHEM-BIOL INTERACT, V283, P97, DOI 10.1016/j.cbi.2018.02.007
   Vigan M, 2010, EUR J DERMATOL, V20, P685, DOI 10.1684/ejd.2010.1066
   Vijayakumar A, 2017, CELL REP, V21, P1021, DOI 10.1016/j.celrep.2017.09.091
   Villanueva-Millán MJ, 2015, J PHYSIOL BIOCHEM, V71, P509, DOI 10.1007/s13105-015-0390-3
   Wada N, 2014, J CHEM NEUROANAT, V61-62, P191, DOI 10.1016/j.jchemneu.2014.09.002
   Walther TC, 2017, ANNU REV CELL DEV BI, V33, P491, DOI 10.1146/annurev-cellbio-100616-060608
   Wang J, 2017, ANN NY ACAD SCI, V1398, P83, DOI 10.1111/nyas.13375
   Wang L, 2019, J SCI FOOD AGR, V99, P4019, DOI 10.1002/jsfa.9629
   Wang Q, 2018, BIOL PHARM BULL, V41, P985, DOI 10.1248/bpb.b17-00724
   Wang WS, 2016, NAT REV MOL CELL BIO, V17, P691, DOI 10.1038/nrm.2016.96
   Wang YF, 2012, INT REV PSYCHIATR, V24, P176, DOI 10.3109/09540261.2012.688195
   Wright SM, 2012, ABDOM IMAGING, V37, P730, DOI 10.1007/s00261-012-9862-x
   Wronska A, 2012, ACTA PHYSIOL, V205, P194, DOI 10.1111/j.1748-1716.2012.02409.x
   Wu HZ, 2017, J CLIN INVEST, V127, P43, DOI [10.1172/JCI88880, 10.1172/jci88880]
   Wu J, 2012, CELL, V150, P366, DOI 10.1016/j.cell.2012.05.016
   Yamamoto T, 2013, SCI REP-UK, V3, DOI 10.1038/srep01518
   Yang A, 2020, BIOCHEM J, V477, P985, DOI 10.1042/BCJ20190468
   Yang Q, 2018, NAT REV MOL CELL BIO, V19, P654, DOI 10.1038/s41580-018-0044-8
   Yen HF, 2015, J FOOD DRUG ANAL, V23, P124, DOI 10.1016/j.jfda.2014.02.004
   Yin CY, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0214606
   Zhan C, 2018, ADV EXP MED BIOL, V1090, P17, DOI 10.1007/978-981-13-1286-1_2
   Zhang RQ, 2016, EUR J DRUG METAB PH, V41, P441, DOI 10.1007/s13318-015-0272-7
   Zhang YJ, 2015, INT J MOL SCI, V16, P7493, DOI 10.3390/ijms16047493
   Zieba DA, 2020, DOMEST ANIM ENDOCRIN, V73, DOI 10.1016/j.domaniend.2020.106472
NR 160
TC 29
Z9 29
U1 7
U2 39
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD NOV
PY 2021
VL 22
IS 21
AR 11832
DI 10.3390/ijms222111832
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA XB2OO
UT WOS:000721171700001
PM 34769261
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wysokinski, A
   Socha, K
   Soltysik, BK
   Kloszewska, I
   Sobów, T
   Kostka, T
AF Wysokinski, Adam
   Socha, Krzysztof
   Soltysik, Bartlomiej Konrad
   Kloszewska, Iwona
   Sobow, Tomasz
   Kostka, Tomasz
TI Levels of C-reactive protein (CRP) in elderly patients with unipolar
   depression - case control analysis
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Article
DE CRP; C-reactive protein; depression; elderly; old age psychiatry
ID CORONARY-HEART-DISEASE; BIPOLAR DISORDER; CARDIOVASCULAR RISK; METABOLIC
   SYNDROME; MENTAL-ILLNESS; SCHIZOPHRENIA; INFLAMMATION; ASSOCIATION;
   POPULATION; SYMPTOMS
AB Aim: C-reactive protein (CRP) is the major acute-phase plasma protein. Studies show that patients with depression have elevated levels of CRP. The aim of the study was to determine differences in CRP serum level in elderly patients with unipolar depression (DEP) compared with non-depressed elderly patients (nonDEP) using case-control analysis.Methods: Serum level of CRP was measured in 404 (DEP: n=202, nonDEP: n=202) Caucasian inpatients aged 60 (350 women, 86.7%; mean age=76.7 years).Results: Mean CRP level in the study groups was: DEP 2.672.56mg/dL, nonDEP 2.41 +/- 2.19mg/dL, the difference was not significant (p=0.96). The overall rate of being above the high level of CRP (set at 3.0mg/L) was 33.2% for DEP and 29.2% for nonDEP groups (p=0.39). It was also found that, in the whole study group, CRP level was not correlated with age (p=0.10).Conclusions: Elderly patients with depression have no increased CRP levels. A high percentage (approximate to 30%) of all subjects had a CRP level >3mg/L, which is the cut-off point for increased cardiovascular risk.
C1 [Wysokinski, Adam; Kloszewska, Iwona] Med Univ Lodz, Dept Old Age Psychiat & Psychot Disorders, Czechoslowacka 8-10, PL-92216 Lodz, Poland.
   [Socha, Krzysztof; Soltysik, Bartlomiej Konrad; Kostka, Tomasz] Med Univ Lodz, Dept Geriatr, Lodz, Poland.
   [Sobow, Tomasz] Med Univ Lodz, Dept Med Psychol, Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz; Medical University
   Lodz
RP Wysokinski, A (corresponding author), Med Univ Lodz, Dept Old Age Psychiat & Psychot Disorders, Czechoslowacka 8-10, PL-92216 Lodz, Poland.
EM adam.wysokinski@umed.lodz.pl
RI Wysokinski, Adam/S-9294-2016; Wysokinski, Adam/G-8174-2014; Soltysik,
   Bartlomiej K./S-9839-2016
OI Wysokinski, Adam/0000-0002-6159-6579; Soltysik, Bartlomiej
   K./0000-0002-1382-3757; Kostka, Tomasz/0000-0003-0437-650X
FU Healthy Ageing Research Center [REGPOT-2012-2013-1, 7FP]
FX The authors are (partially) supported by the Healthy Ageing Research
   Center (REGPOT-2012-2013-1, 7FP).
CR Acharjee S, 2008, CLIN INTERV AGING, V3, P299
   Akanji AO, 2009, PSYCHIAT RES, V169, P56, DOI 10.1016/j.psychres.2008.06.010
   Basterzi AD, 2005, HUM PSYCHOPHARM CLIN, V20, P473, DOI 10.1002/hup.717
   Brown AS, 2014, MOL PSYCHIATR, V19, P259, DOI 10.1038/mp.2012.197
   Canetta S, 2014, AM J PSYCHIAT, V171, P960, DOI 10.1176/appi.ajp.2014.13121579
   Chambers JC, 2001, CIRCULATION, V104, P145, DOI 10.1161/01.CIR.104.2.145
   CRUM RM, 1993, JAMA-J AM MED ASSOC, V269, P2386, DOI 10.1001/jama.269.18.2386
   Dargél AA, 2015, J CLIN PSYCHIAT, V76, P142, DOI 10.4088/JCP.14r09007
   Diaz FJ, 2010, SCHIZOPHR RES, V121, P207, DOI 10.1016/j.schres.2010.06.002
   Dickerson F, 2013, J AFFECT DISORDERS, V150, P456, DOI 10.1016/j.jad.2013.04.039
   Dickerson F, 2013, SCHIZOPHR RES, V143, P198, DOI 10.1016/j.schres.2012.10.041
   Douglas KM, 2004, PSYCHOSOM MED, V66, P679, DOI 10.1097/01.psy.0000138132.66332.85
   Eller T, 2008, PROG NEURO-PSYCHOPH, V32, P445, DOI 10.1016/j.pnpbp.2007.09.015
   Forti P, 2010, DEMENT GERIATR COGN, V29, P11, DOI 10.1159/000261644
   Goldstein BI, 2009, J CLIN PSYCHIAT, V70, P1078, DOI 10.4088/JCP.08r04505
   Hamdani N, 2013, CURR PSYCHIAT REP, V15, DOI 10.1007/s11920-013-0387-y
   Heald A, 2015, SCHIZOPHR RES, V169, P494, DOI 10.1016/j.schres.2015.10.043
   Irwin MR, 2007, BRAIN BEHAV IMMUN, V21, P374, DOI 10.1016/j.bbi.2007.01.010
   Jialal I, 2004, HYPERTENSION, V44, P6, DOI 10.1161/01.HYP.0000130484.20501.df
   Jiang P, 2014, PSYCHIAT RES, V215, P806, DOI 10.1016/j.psychres.2013.12.037
   Joseph J, 2015, SCHIZOPHR RES, V168, P456, DOI 10.1016/j.schres.2015.08.019
   Karlovic D, 2012, PSYCHIAT RES, V198, P74, DOI 10.1016/j.psychres.2011.12.007
   Klemettilä JP, 2015, EUR PSYCHIAT, V30, DOI 10.1016/j.eurpsy.2014.08.006
   Klemettilä JP, 2014, PSYCHIAT RES, V218, P277, DOI 10.1016/j.psychres.2014.04.049
   Kop WJ, 2002, AM J CARDIOL, V89, P419, DOI 10.1016/S0002-9149(01)02264-0
   Lawrence D, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-462
   Lepping P, 2011, J CLIN PSYCHIAT, V72, P273, DOI 10.4088/JCP.09r05268yel
   Marc LG, 2008, AM J GERIAT PSYCHIAT, V16, P914, DOI 10.1097/JGP.0b013e318186bd67
   McDade Thomas W., 2013, Evolution Medicine and Public Health, P18, DOI 10.1093/emph/eos004
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P295, DOI 10.1093/schbul/sbs082
   Pan A, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001392
   Penninx BWJH, 2003, BIOL PSYCHIAT, V54, P566, DOI 10.1016/S0006-3223(02)01811-5
   Pfützner A, 2006, DIABETES TECHNOL THE, V8, P28, DOI 10.1089/dia.2006.8.28
   Reddy SM, 2013, PSYCHIAT DANUB, V25, pS94
   Ridker PM, 2003, CIRCULATION, V108, pE81, DOI 10.1161/01.CIR.0000093381.57779.67
   Rojas P, 2011, PSYCHIAT RES, V190, P372, DOI 10.1016/j.psychres.2011.05.023
   Sobocki P, 2006, J MENT HEALTH POLICY, V9, P87
   Song BM, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2014-006429
   Steptoe A, 2003, PSYCHOL MED, V33, P667, DOI 10.1017/S0033291702007250
   Suvisaari Jaana, 2013, Infectious Disorders - Drug Targets, V13, P59
   Taylor VH, 2012, CAN J PSYCHIAT, V57, P5, DOI 10.1177/070674371205700103
   Whooley MA, 2007, BIOL PSYCHIAT, V62, P314, DOI 10.1016/j.biopsych.2006.10.016
   Wium-Andersen MK, 2014, SCHIZOPHRENIA BULL, V40, P1117, DOI 10.1093/schbul/sbt120
   Wium-Andersen MK, 2014, BIOL PSYCHIAT, V76, P249, DOI 10.1016/j.biopsych.2013.10.009
   Woloshin S, 2005, NEW ENGL J MED, V352, P1611, DOI 10.1056/NEJM200504143521525
   Wysokinski A, 2015, NORD J PSYCHIAT, V69, P346, DOI 10.3109/08039488.2014.984755
   Wysokinski A, 2012, PSYCHIAT DANUB, V24, P314
   Yeh ETH, 2003, CIRCULATION, V107, P370, DOI 10.1161/01.CIR.0000053731.05365.5A
   Zalli A, 2016, PSYCHOPHARMACOLOGY, V233, P1669, DOI 10.1007/s00213-015-3919-9
NR 49
TC 4
Z9 4
U1 0
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0803-9488
EI 1502-4725
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PD OCT
PY 2016
VL 70
IS 7
BP 503
EP 507
DI 10.3109/08039488.2016.1174298
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DV6IK
UT WOS:000383037300004
PM 27117065
DA 2025-06-11
ER

PT J
AU Birnbaum-Weitzman, O
   Goldberg, R
   Hurwitz, BE
   Llabre, MM
   Gellman, MD
   Gutt, M
   McCalla, JR
   Mendez, AJ
   Schneiderman, N
AF Birnbaum-Weitzman, O.
   Goldberg, R.
   Hurwitz, B. E.
   Llabre, M. M.
   Gellman, M. D.
   Gutt, M.
   McCalla, J. R.
   Mendez, A. J.
   Schneiderman, N.
TI Depressive symptoms linked to 1-h plasma glucose concentrations during
   the oral glucose tolerance test in men and women with the metabolic
   syndrome
SO DIABETIC MEDICINE
LA English
DT Article
ID INSULIN-RESISTANCE; RISK; METAANALYSIS; ASSOCIATION; SENSITIVITY;
   INDIVIDUALS; PREVALENCE; INVENTORY; INDEXES
AB Aims
   The addition of the 1-h plasma glucose concentration measure from an oral glucose tolerance test to prediction models of future Type2 diabetes has shown to significantly strengthen their predictive power. The present study examined the relationship between severity of depressive symptoms and hyperglycaemia, focusing on the 1-h glucose concentration vs. fasting and 2-h glucose measures from the oral glucose tolerance test.
   Methods
   Participants included 140 adults with the metabolic syndrome and without diabetes who completed a baseline psychobiological assessment and a 2-h oral glucose tolerance test, with measurements taken every 30min. Depressive symptoms were assessed using the Beck Depression Inventory.
   Results
   Multivariate linear regression revealed that higher levels of depressive symptoms were associated with higher levels of 1-h plasma glucose concentrations after adjusting for age, gender, ethnicity, BMI, antidepressant use and high-sensitivity C-reactive protein.
   Results were maintained after controlling for fasting glucose as well as for indices of insulin resistance and secretion. Neither fasting nor 2-h plasma glucose concentrations were significantly associated with depressive symptoms.
   Conclusions
   Elevated depressive symptoms in persons with the metabolic syndrome were associated with greater glycaemic excursion 1-h following a glucose load that was not accounted for by differences in insulin secretory function or insulin sensitivity. Consistent with previous findings, this study highlights the value of the 1-h plasma glucose measurement from the oral glucose tolerance test in the relation between depressive symptoms and glucose metabolism as an indicator of metabolic abnormalities not visible when focusing on fasting and 2-h post-oral glucose tolerance test measurements alone.
C1 [Birnbaum-Weitzman, O.; Hurwitz, B. E.; Llabre, M. M.; Gellman, M. D.; Schneiderman, N.] Univ Miami, Behav Med Res Ctr, Miami, FL 33136 USA.
   [Birnbaum-Weitzman, O.; Hurwitz, B. E.; Llabre, M. M.; Gellman, M. D.; McCalla, J. R.; Schneiderman, N.] Univ Miami, Dept Psychol, Miami, FL USA.
   [Goldberg, R.; Hurwitz, B. E.; Gutt, M.; Mendez, A. J.; Schneiderman, N.] Univ Miami, Dept Med, Div Endocrinol & Metab, Miami, FL USA.
   [Goldberg, R.; Mendez, A. J.] Univ Miami, Diabet Res Inst, Miami, FL USA.
   [Schneiderman, N.] Univ Miami, Dept Psychiat & Behav Sci, Miami, FL USA.
C3 University of Miami; University of Miami; University of Miami;
   University of Miami; University of Miami
RP Birnbaum-Weitzman, O (corresponding author), Univ Miami, Behav Med Res Ctr, Miami, FL 33136 USA.
EM oweitzman@miami.edu
RI Mendez, Armando/HQY-1723-2023
FU National Heart, Lung and Blood Institute (NHLBI) Behavioral Medicine in
   Cardiovascular Disease Research Training Grant [T32HL007426-33];
   National Heart, Lung and Blood Institute (NHLBI) Biobehavioral Bases of
   CHD Risk and Management Program Project grant [HL36588]
FX This study was supported by National Heart, Lung and Blood Institute
   (NHLBI) Behavioral Medicine in Cardiovascular Disease Research Training
   Grant (T32HL007426-33) and Biobehavioral Bases of CHD Risk and
   Management Program Project grant (HL36588).
CR Abdul-Ghani MA, 2008, DIABETES CARE, V31, P1650, DOI 10.2337/dc08-0225
   Abdul-Ghani MA, 2007, DIABETES CARE, V30, P1544, DOI 10.2337/dc06-1331
   Abdul-Ghani MA, 2010, DIABETES CARE, V33, P557, DOI 10.2337/dc09-1145
   Abdul-Ghani MA, 2009, DIABETES CARE, V32, pS194, DOI 10.2337/dc09-S309
   Barefoot JC, 1996, CIRCULATION, V93, P1976, DOI 10.1161/01.CIR.93.11.1976
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Gutt M, 2000, DIABETES RES CLIN PR, V47, P177, DOI 10.1016/S0168-8227(99)00116-3
   Hanson RL, 2000, AM J EPIDEMIOL, V151, P190
   Kan C, 2013, DIABETES CARE, V36, P480, DOI 10.2337/dc12-1442
   Knol MJ, 2007, PSYCHOSOM MED, V69, P300, DOI 10.1097/PSY.0b013e31805f48b9
   Lustman PJ, 2007, PSYCHOSOM MED, V69, P297, DOI 10.1097/PSY.0b013e318060cc2d
   Manco M, 2010, DIABETES CARE, V33, P2090, DOI 10.2337/dc09-2261
   Mäntyselkä P, 2011, DIABETES CARE, V34, P71, DOI 10.2337/dc10-1044
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Nouwen A, 2011, DIABETES CARE, V34, P752, DOI 10.2337/dc10-1414
   Okamura F, 2000, METABOLISM, V49, P1255, DOI 10.1053/meta.2000.9515
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Rhee MK, 2008, DIABETIC MED, V25, P1361, DOI 10.1111/j.1464-5491.2008.02543.x
   Schafer JL, 2002, PSYCHOL METHODS, V7, P147, DOI 10.1037//1082-989X.7.2.147
   Shen BJ, 2006, ANN EPIDEMIOL, V16, P131, DOI 10.1016/j.annepidem.2005.06.049
   Shomaker LB, 2011, DIABETES CARE, V34, P2458, DOI 10.2337/dc11-1131
   Skaff MM, 2009, HEALTH PSYCHOL, V28, P265, DOI 10.1037/a0014429
   Steer RA, 2001, PSYCHOL REP, V88, P1075, DOI 10.2466/PR0.88.4.1075-1076
   Suarez EC, 2006, HEALTH PSYCHOL, V25, P484, DOI 10.1037/0278-6133.25.4.484
   Unwin N, 2002, DIABETIC MED, V19, P708, DOI 10.1046/j.1464-5491.2002.00835.x
   Wagner J, 2009, DIABETES RES CLIN PR, V86, P96, DOI 10.1016/j.diabres.2009.06.024
   Zhou WB, 2006, EUR J ENDOCRINOL, V155, P191, DOI 10.1530/eje.1.02188
NR 30
TC 3
Z9 3
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3071
EI 1464-5491
J9 DIABETIC MED
JI Diabetic Med.
PD MAY
PY 2014
VL 31
IS 5
BP 630
EP 636
DI 10.1111/dme.12356
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AE6QD
UT WOS:000334117700019
PM 24344735
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Verhoeven, V
   Van der Auwera, A
   Van Gaal, L
   Remmen, R
   Apers, S
   Stalpaert, M
   Wens, J
   Hermans, N
AF Verhoeven, Veronique
   Van der Auwera, Anastasia
   Van Gaal, Luc
   Remmen, Roy
   Apers, Sandra
   Stalpaert, Michel
   Wens, Johan
   Hermans, Nina
TI Can red yeast rice and olive extract improve lipid profile and
   cardiovascular risk in metabolic syndrome?: a double blind, placebo
   controlled randomized trial
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE Cardiovascular prevention; Metabolic syndrome; Statins; Red yeast rice;
   Olive; Cholesterol
ID LOW-DENSITY-LIPOPROTEIN; PHOTODIODE-ARRAY DETECTOR; OXIDATIVE STRESS;
   BLOOD-PRESSURE; MEDITERRANEAN DIET; STATIN THERAPY; CHOLESTEROL;
   OBESITY; DISEASE; INFLAMMATION
AB Background: Metabolic syndrome (MetS) comprises a spectrum of clinical phenotypes in which dyslipidemia, dysglycemia and hypertension are clustered and where all share a high level of oxidative stress and an increased risk of cardiovascular disease. This study examines the effect of a nutritional supplement combining red yeast rice and olive fruit extract on the lipid profile and on oxidative stress in a population of patients with MetS.
   Methods: In a double blind placebo controlled randomized trial, 50 persons with MetS, as defined by the ATPIII criteria, received the study product or placebo for 8 weeks. The study product contained 10.82 mg of monacolins and 9,32 mg of hydroxytyrosol per capsule, and is commercialized as Cholesfytol plus. The primary outcome measure was the difference in LDL reduction between intervention and control groups. Furthermore, differences in changes of CH, HDL, ApoA1, ApoB, HbA1c and oxLDL were measured, as well as side-effects, CK elevation, changes in clinical parameters and in cardiovascular risk.
   Results: In the intervention group, LDL cholesterol was lowered by 24% whereas it increased by 1% in the control group (p < 0.001). Other effects observed were a change in total cholesterol (-17% in the intervention group vs +2% in the control group, p < 0.001), apolipoprotein B (-15% vs +6%, p < 0.001), and TG (-9% vs + 16%, p = 0.02). Oxidized LDL decreased by 20% vs an increase of 5% in the control group (p < 0.001). Systolic and diastolic arterial blood pressure decreased significantly by 10 mmHg (vs 0% in the control group, p = 0.001) and 7 mmHg (vs 0% in the control group, p = 0.05) respectively. One person in the intervention group, who suffered from Segawa's syndrome, dropped out because of severe muscle ache.
   Conclusions: The combination of active products in this study may be an alternative approach to statins in people who do not need, or cannot or do not want to be treated with chemical statins. Side effects, effects on oxidative stress and on glucose metabolism need to be examined more thoroughly.
C1 [Verhoeven, Veronique; Remmen, Roy; Wens, Johan] Univ Antwerp, Fac Med & Hlth Sci, Acad Ctr Primary & Interdisciplinary Care, B-2020 Antwerp, Belgium.
   [Van der Auwera, Anastasia; Apers, Sandra; Hermans, Nina] Univ Antwerp, Nat Prod & Food Res & Anal NatuRA, Dept Pharmaceut Sci, B-2020 Antwerp, Belgium.
   [Van Gaal, Luc] Univ Antwerp Hosp, Dept Endocrinol Diabetol & Metab, Fac Med, B-2650 Antwerp, Belgium.
   [Stalpaert, Michel] Sonic Healthcare Benelux, Lab Mol & Clin Pathol RIATOL, AML, B-2020 Antwerp, Belgium.
C3 University of Antwerp; University of Antwerp; University of Antwerp
RP Verhoeven, V (corresponding author), Univ Antwerp, Fac Med & Hlth Sci, Acad Ctr Primary & Interdisciplinary Care, B-2020 Antwerp, Belgium.
EM veronique.verhoeven@uantwerpen.be
RI Apers, Sandra/P-6286-2016; Remmen, Roy/H-7302-2016; Wens,
   Johan/K-2705-2013; Hermans, Nina/A-5244-2017; Verhoeven,
   Veronique/B-5915-2017
OI Wens, Johan/0000-0002-0229-9064; Hermans, Nina/0000-0003-3946-7313;
   Verhoeven, Veronique/0000-0002-3708-6501
FU Tilman sa, Z. I. Sud 15, Baillonville, Belgium
FX This study was partly funded by a grant of Tilman sa, Z. I. Sud 15,
   B-5377 Baillonville, Belgium who produces the product under study
   (commercially available as Cholesfytol plus). Tilman had no
   methodological or any other input in design, execution or reporting of
   this study. Tilman had no access to the detailed study protocol, names
   of study participants or raw study data. Before starting the study, it
   was agreed specifically that the study would be published, regardless of
   the results.
CR Agostoni C, 2011, EFSA J, V9, DOI 10.2903/j.efsa.2011.2033
   [Anonymous], 2011, EFSA J, V9, DOI 10.2903/j.efsa.2011.2304
   [Anonymous], 2011, EFSA J, V8, P9
   [Anonymous], BMJ
   Ballantyne CM, 2008, J AM COLL CARDIOL, V52, P626, DOI 10.1016/j.jacc.2008.04.052
   Becker DJ, 2009, ANN INTERN MED, V150, P830, DOI 10.7326/0003-4819-150-12-200906160-00006
   Bogsrud MP, 2010, SCAND CARDIOVASC J, V44, P197, DOI 10.3109/14017431003624123
   Chen CH, 2013, INT J PHARMACEUT, V444, P18, DOI 10.1016/j.ijpharm.2013.01.028
   Conroy RM, 2003, EUR HEART J, V24, P987, DOI 10.1016/S0195-668X(03)00114-3
   Doménech M, 2014, HYPERTENSION, V64, P69, DOI 10.1161/HYPERTENSIONAHA.113.03353
   Dunstan DW, 2002, DIABETES CARE, V25, P829, DOI 10.2337/diacare.25.5.829
   Ervin R Bethene, 2009, Natl Health Stat Report, P1
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gaede P, 2003, NEW ENGL J MED, V348, P383, DOI 10.1056/NEJMoa021778
   Gilani AH, 2005, INT J FOOD SCI NUTR, V56, P613, DOI 10.1080/09637480500539420
   Go AS, 2014, CIRCULATION, V129, P399, DOI 10.1161/01.cir.0000442015.53336.12
   Gordon RY, 2010, ARCH INTERN MED, V170, P1722, DOI 10.1001/archinternmed.2010.382
   Grattagliano I, 2008, J NUTR BIOCHEM, V19, P491, DOI 10.1016/j.jnutbio.2007.06.011
   Grundy SM, 2014, J CLIN LIPIDOL, V8, P29, DOI 10.1016/j.jacl.2013.12.005
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Holvoet P, 2008, JAMA-J AM MED ASSOC, V299, P2287, DOI 10.1001/jama.299.19.2287
   Hsin-Ping O, 2009, FOOD SCI TECHNOL, V42, P292
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Lapi F, 2008, BRIT J CLIN PHARMACO, V66, P572, DOI 10.1111/j.1365-2125.2008.03224.x
   Li YG, 2005, J PHARMACEUT BIOMED, V39, P82, DOI 10.1016/j.jpba.2005.03.005
   Li YG, 2004, J PHARMACEUT BIOMED, V35, P1101, DOI 10.1016/j.jpba.2004.04.004
   Mancini GBJ, 2011, CAN J CARDIOL, V27, P635, DOI 10.1016/j.cjca.2011.05.007
   Matikainen N, 2012, CURR CARDIOL REP, V14, P721, DOI 10.1007/s11886-012-0309-3
   Misra A, 2008, J CLIN ENDOCR METAB, V93, pS9, DOI 10.1210/jc.2008-1595
   Mueller PS, 2006, ANN INTERN MED, V145, P474, DOI 10.7326/0003-4819-145-6-200609190-00021
   Nauck M, 2002, CLIN CHEM, V48, P236
   Navarra T, 2010, J ATHEROSCLER THROMB, V17, P317, DOI 10.5551/jat.3228
   Preiss D, 2011, JAMA-J AM MED ASSOC, V305, P2556, DOI 10.1001/jama.2011.860
   Psaltopoulou T, 2004, AM J CLIN NUTR, V80, P1012, DOI 10.1093/ajcn/80.4.1012
   RIFAI N, 1992, CLIN CHEM, V38, P150
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Toledo E, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-207
   Tsimikas S, 2011, CURR PHARM DESIGN, V17, P27, DOI 10.2174/138161211795049831
   Van Gaal LF, 2006, NATURE, V444, P875, DOI 10.1038/nature05487
   Van Guilder GP, 2006, OBESITY, V14, P2127, DOI 10.1038/oby.2006.248
   Venero CV, 2010, AM J CARDIOL, V105, P664, DOI 10.1016/j.amjcard.2009.10.045
   Verhoeven V, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-178
   Wierzbicki AS, 2012, CURR OPIN CARDIOL, V27, P398, DOI 10.1097/HCO.0b013e328353adc1
   Yinhua L, 2014, PLOS ONE, V9
NR 44
TC 42
Z9 45
U1 3
U2 31
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD MAR 10
PY 2015
VL 15
AR 52
DI 10.1186/s12906-015-0576-9
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA CD6KP
UT WOS:000351198300001
PM 25879228
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sipahioglu, NT
   Ilerigelen, B
   Gungor, ZB
   Ayaz, G
   Ekmekci, H
   Gurel, CB
   Can, G
   Sonmez, H
   Ulutin, T
   Sipahioglu, F
AF Sipahioglu, Nurver Turfaner
   Ilerigelen, Bans
   Gungor, Zeynep B.
   Ayaz, Gulsel
   Ekmekci, Hakan
   Gurel, Cigdem Bayram
   Can, Gunay
   Sonmez, Huseyin
   Ulutin, Turgut
   Sipahioglu, Fikret
TI Relation of Biochemical Parameters with Flow-mediated Dilatation in
   Patients with Metabolic Syndrome
SO CHINESE MEDICAL JOURNAL
LA English
DT Article
DE Endothelial Dysfunction; Metabolic Syndrome; Oxidative Stress; Smoking
ID CARDIOVASCULAR RISK-FACTORS; OXIDATIVE STRESS; ENDOTHELIAL FUNCTION;
   BRACHIAL-ARTERY; NITRIC-OXIDE; SYNTHASE EXPRESSION; NATIONAL-HEALTH;
   PREDICTS; VASODILATION; ASSOCIATION
AB Background: Metabolic syndrome (MetS) is one of the high cardiovascular (CV) situations. Endothelial dysfunction, which is a common finding in patients with MetS, is related with increased CV risk. In patients with MetS, the effect of the maj or CV risk factors, not included in the MetS definition, on endothelial dysfunction is not well known. The aim of this study was to determine the effect of major CV risk factors such as gender, smoking, family history, and biochemical parameters on endothelial dysfunction in patients with MetS.
   Methods: The study was performed between December 2010 andAugust 2014. Atotal of 55 patients (15 females and 40 males) with MetS and 81 healthy controls (37 females and 44 males) with a body mass index < 25 kg/m(2) were enrolled in the study. Endothelial dysfunction was measured by flow-mediated dilatation (FMD), oxidative stress parameters; high-sensitivity C-reactive protein (hs-CRP), oxidized low-density lipoprotein (ox-LDL), endothelial nitric oxide synthase (e-NOS), nitric oxide, and cell adhesion markers; von Willebrand factor, and e-selectin. Platelet aggregation (endothelial adenosine diphosphate), total platelet count, and mean platelet volume were additionally analyzed and demographic parameters were explored. Student's t-test, Mann-Whitney U-test, and Chi-square test were used to analyze the results.
   Results: The fasting blood glucose (z = 3.52, P = 0.001), hs-CRP (z = 3.23, P = 0.004), ox-LDL (z = 2.62, P = 0.013), and e-NOS (z = 2.22, P = 0.026) levels and cardiac risk score (z = 5.23, P < 0.001) were significantly higher in patients with MetS compared with the control group. Smoking was correlated with decreased FMD (chi(2) = 9.26, P = 0.002) in MetS patients but not in the control group.
   Conclusions: Increased ox-LDL, hs-CRP, and e-NOS are likely to be a result of oxidative stress, a condition in which an imbalance occurs between the production and inactivation of reactive nitrogen and oxygen species. In addition, in patients with MetS, smoking is independently related to endothelial dysfunction.
C1 [Sipahioglu, Nurver Turfaner] Istanbul Univ, Cerrahpasa Med Fac, Dept Family Med, TR-34303 Istanbul, Turkey.
   [Ilerigelen, Bans] Istanbul Univ, Cerrahpasa Med Fac, Dept Cardiol, TR-34303 Istanbul, Turkey.
   [Gungor, Zeynep B.; Ekmekci, Hakan; Sonmez, Huseyin] Istanbul Univ, Cerrahpasa Med Fac, Dept Biochem, TR-34303 Istanbul, Turkey.
   [Ayaz, Gulsel; Gurel, Cigdem Bayram; Ulutin, Turgut] Istanbul Univ, Cerrahpasa Med Fac, Dept Med Biol, TR-34303 Istanbul, Turkey.
   [Can, Gunay] Istanbul Univ, Cerrahpasa Med Fac, Dept Publ Hlth, TR-34303 Istanbul, Turkey.
   [Sipahioglu, Fikret] Istanbul Univ, Cerrahpasa Med Fac, Dept Internal Med, TR-34303 Istanbul, Turkey.
C3 Istanbul University; Istanbul University - Cerrahpasa; Istanbul
   University; Istanbul University - Cerrahpasa; Istanbul University -
   Cerrahpasa; Istanbul University; Istanbul University; Istanbul
   University - Cerrahpasa; Istanbul University - Cerrahpasa; Istanbul
   University; Istanbul University; Istanbul University - Cerrahpasa
RP Can, G (corresponding author), Istanbul Univ, Cerrahpasa Med Fac, Dept Publ Hlth, TR-34303 Istanbul, Turkey.
EM nurverdi@gmail.com
RI Ulutin, Turgut/C-9501-2019; Sipahioglu, Nurver/AAA-3978-2020; Sönmez,
   Hüseyin/D-2756-2019; Can, Günay/AAB-1669-2020; GUREL,
   CIGDEM/AAN-7369-2021; Ekmekci, Hakan/D-4969-2019; Gungor,
   Zeynep/D-3779-2019
OI Ekmekci, Hakan/0000-0002-5605-2980; Sonmez, Huseyin
   Avni/0000-0003-2344-0888; Bayram Gurel, Cigdem/0000-0001-9407-7735;
   Gungor, Zeynep/0000-0002-0649-844X; CAN, GUNAY/0000-0001-5815-6700
FU Scientific Research Project Unit, Istanbul University [268573]
FX This work was supported by Scientific Research Project Unit, Istanbul
   University (No: 268573).
CR Ahirwar AK, 2015, HORM MOL BIOL CLIN I, V24, P131, DOI 10.1515/hmbci-2015-0039
   Bae Yun-Jung, 2013, Clin Nutr Res, V2, P91, DOI 10.7762/cnr.2013.2.2.91
   Betik AC, 2004, AM J PHYSIOL-HEART C, V286, pH442, DOI 10.1152/ajpheart.00314.2003
   Corretti MC, 2002, J AM COLL CARDIOL, V39, P257, DOI 10.1016/S0735-1097(01)01746-6
   Ding H, 2007, J CELL PHYSIOL, V212, P682, DOI 10.1002/jcp.21063
   Fernandes IA, 2014, CLIN PHYSIOL FUNCT I, V34, P270, DOI 10.1111/cpf.12092
   Golledge J, 2008, CARDIOLOGY, V111, P51, DOI 10.1159/000113428
   Higashi Y, 2009, CIRC J, V73, P411, DOI 10.1253/circj.CJ-08-1102
   Jialal I, 2012, J CLIN ENDOCR METAB, V97, pE1844, DOI 10.1210/jc.2012-2498
   Kang JH, 2015, METAB SYNDR RELAT D, V13, P140, DOI 10.1089/met.2014.0124
   Karahan O, 2013, BRATISL MED J, V114, P721, DOI 10.4149/BLL_2013_152
   Kosola J, 2013, METABOLISM, V62, P992, DOI 10.1016/j.metabol.2013.01.013
   Lanza GA, 2001, EUR HEART J, V22, P1924, DOI 10.1053/euhj.2001.2624
   Leiva E, 2013, BIOL TRACE ELEM RES, V151, P1, DOI 10.1007/s12011-012-9525-3
   Li HG, 2002, NITRIC OXIDE-BIOL CH, V7, P149, DOI 10.1016/S1089-8603(02)00111-8
   Li J, 2012, MAYO CLIN PROC, V87, P968, DOI 10.1016/j.mayocp.2012.07.004
   Lin Jin-xiu, 2007, Zhonghua Xinxueguanbing Zazhi, V35, P710
   Lind L, 2015, CLIN PHYSIOL FUNCT I, V35, P411, DOI 10.1111/cpf.12177
   Mattsson N, 2008, EUR HEART J, V29, P784, DOI 10.1093/eurheartj/ehm576
   Oh SW, 2005, DIABETES CARE, V28, P2064, DOI 10.2337/diacare.28.8.2064
   Onat A, 2015, J INVEST MED, V63, P796, DOI 10.1097/JIM.0000000000000203
   Palmieri VO, 2006, J NUTR, V136, P3022, DOI 10.1093/jn/136.12.3022
   Pechánová O, 2015, BRIT J PHARMACOL, V172, P1415, DOI 10.1111/bph.12960
   Poredos P, 2013, J ATHEROSCLER THROMB, V20, P1
   Razny U, 2010, J PHYSIOL PHARMACOL, V61, P607
   Ryliskyte L, 2003, SEMIN CARDIOL, V3, P11
   Skaug EA, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0101371
   Suboc TMB, 2013, PHYSIOL REP, V1, DOI 10.1002/phy2.58
   Title LM, 2008, VASC MED, V13, P263, DOI 10.1177/1358863X08095154
   Tsai JS, 2015, EUR J CLIN INVEST, V45, P452, DOI 10.1111/eci.12425
   Uzun H, 2004, J HUM HYPERTENS, V18, P523, DOI 10.1038/sj.jhh.1001697
   Vykoukal D, 2011, J VASC SURG, V54, P819, DOI 10.1016/j.jvs.2011.01.003
   Wendelhag I, 2002, J INTERN MED, V252, P305, DOI 10.1046/j.1365-2796.2002.01036.x
   Yang PT, 2014, J THORAC DIS, V6, P1441, DOI 10.3978/j.issn.2072-1439.2014.08.04
   Zhao YZ, 2015, J PHARMACOL SCI, V129, P83, DOI 10.1016/j.jphs.2015.09.002
   Zhen JH, 2008, AM J HYPERTENS, V21, P28, DOI 10.1038/ajh.2007.14
NR 36
TC 4
Z9 4
U1 0
U2 15
PU MEDKNOW PUBLICATIONS & MEDIA PVT LTD
PI MUMBAI
PA B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075,
   INDIA
SN 0366-6999
J9 CHINESE MED J-PEKING
JI Chin. Med. J.
PD JUL 5
PY 2017
VL 130
IS 13
BP 1564
EP 1569
DI 10.4103/0366-6999.208231
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EY9EE
UT WOS:000404301100009
PM 28639572
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Werba, JP
   Giroli, MG
   Simonelli, N
   Vigo, L
   Gorini, A
   Bonomi, A
   Veglia, F
   Tremoli, E
AF Werba, Jose P.
   Giroli, Monica G.
   Simonelli, Niccolo
   Vigo, Lorenzo
   Gorini, Alessandra
   Bonomi, Alice
   Veglia, Fabrizio
   Tremoli, Elena
TI Uptake and effectiveness of a primary cardiovascular prevention program
   in an underserved multiethnic urban community
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Primary cardiovascular prevention program; Communities; Inclusiveness;
   Multidisciplinary care
ID HEALTH LITERACY; BLOOD-PRESSURE; RISK-FACTORS; DISEASE PREVENTION;
   FOLLOW-UP; PREVALENCE; INDIVIDUALS; POPULATIONS; PERCEPTION; DEPRESSION
AB Background and aims: Cardiometabolic risk is increased among disadvantaged people and ethnic minorities. Paradoxically, their uptake of primary cardiovascular prevention is relatively low. New strategies are needed to tackle this public health problem. Aims of this study were to assess the uptake (as well as its determinants) and effectiveness of a primary cardiovascular prevention program for communities devised to facilitate access of disadvantaged and inclusion of ethnic minorities in addition to providing a state-of-the-art interdisciplinary personalized care.
   Methods and results: Single center, hospital-based, open study. All the residents in an underserved multiethnic urban community aged 40-65 years (n = 1646, 43.6% immigrants) were proactively invited by post mail to participate in a cardiovascular prevention program and different approaches were adopted to promote accessibility and inclusiveness. Program uptake was 23% and individual features independently associated with program uptake were status of immigrant (OR [CI 95%]: 3.6 [2.6-5.1]), higher educational level (3.6 [2.8-4.7]), and female gender (1.6 [1.2-2.1]). Retention was 82% at 6 months and 69% at 12 months. A predefined outcome of global cardiovascular risk improvement at 12 months in subjects with glycaemia >126 mg/dl, LDL-C >115 mg/dl, systolic blood pressure >= 140 mmHg or BMI >28 at baseline was reached in 35%, 33%, 37% and 7% of the patients, respectively. 20% of smokers quitted and significant favorable changes were reported in diet quality, anxiety, depression and physical activity.
   Conclusion: Access inequalities to effective prevention may be counteracted, but increasing global uptake requires further upstream sensitization and awareness actions. (C) 2022 The Author(s). Published by Elsevier B.V. on behalf of The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University.
C1 [Werba, Jose P.; Giroli, Monica G.; Simonelli, Niccolo; Vigo, Lorenzo; Bonomi, Alice; Veglia, Fabrizio; Tremoli, Elena] Ctr Cardiol Monzino, IRCCS, Via Carlo Parea 4, I-20138 Milan, Italy.
   [Simonelli, Niccolo] Azienda Osped Ss Antonio & Biagio & Cesare Arrigo, Struttura Complessa Cardiol, I-15121 Alessandria, Italy.
   [Gorini, Alessandra] Univ Milan, Dept Oncol & Hematooncol, Via Santa Sofia 9-A, I-20122 Milan, Italy.
   [Gorini, Alessandra] Ist Clin Sci Maugeri Milano, IRCCS, I-20138 Milan, Italy.
   [Veglia, Fabrizio; Tremoli, Elena] Maria Cecilia Hosp, Via Corriera 1, I-48033 Cotignola Ravenna, Italy.
C3 IRCCS Centro Cardiologico Monzino; Azienda Ospedaliera SS Antonio Biagio
   Cesare Arrigo; University of Milan; Maria Cecilia Hospital
RP Werba, JP (corresponding author), Ctr Cardiol Monzino, Via Parea 4, I-20138 Milan, Italy.
EM pablo.werba@ccfm.it
RI Bonomi, Alice/AAB-6147-2020; Werba, José/AAC-8973-2019; Gorini,
   Alessandra/C-6689-2011; Giroli, Monica Gianna/D-4323-2019; Veglia,
   Fabrizio/K-1958-2016
OI Gorini, Alessandra/0000-0003-3216-1784; Giroli, Monica
   Gianna/0000-0002-9200-8821; Veglia, Fabrizio/0000-0002-9378-8874;
   Bonomi, Alice/0000-0001-5409-0791
FU Italian Ministry of Health
FX This work was funded by the Italian Ministry of Health, Ricerca Corrente
   to Centro Cardiologico Monzino, IRCCS, years 2014e2019.
CR Agyemang C, 2002, J HUM HYPERTENS, V16, P739, DOI 10.1038/sj.jhh.1001488
   Agyemang C, 2019, J TRAVEL MED, V26, DOI 10.1093/jtm/tay107
   Alwan H, 2009, EUR J CARDIOV PREV R, V16, P556, DOI 10.1097/HJR.0b013e32832d194d
   Anand SS, 2006, INT J EPIDEMIOL, V35, P1239, DOI 10.1093/ije/dyl163
   Martínez-González MA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043134
   [Anonymous], COMUNI ITALIANI
   Badenbroek IF, 2020, PREV MED REP, V19, DOI 10.1016/j.pmedr.2020.101092
   Baldissera S, 2011, PREV CHRONIC DIS, V8
   Bender AM, 2014, EUR J PREV CARDIOL, V21, P899, DOI 10.1177/2047487312472076
   BROADHEAD WE, 1988, MED CARE, V26, P709, DOI 10.1097/00005650-198807000-00006
   Buja A, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-504
   Burke LE, 1997, ANN BEHAV MED, V19, P239, DOI 10.1007/BF02892289
   Cappuccio FP, 1997, HEART, V78, P555, DOI 10.1136/hrt.78.6.555
   Celano CM, 2013, CIRC-CARDIOVASC QUAL, V6, P498, DOI 10.1161/CIRCOUTCOMES.111.000049
   Cooper R, 1997, AM J PUBLIC HEALTH, V87, P160, DOI 10.2105/AJPH.87.2.160
   Coppo A, 2017, EUR J PUBLIC HEALTH, V27, P717, DOI 10.1093/eurpub/ckw262
   Cruickshank JK, 2001, INT J EPIDEMIOL, V30, P111, DOI 10.1093/ije/30.1.111
   Dalton ARH, 2011, J PUBLIC HEALTH-UK, V33, P422, DOI 10.1093/pubmed/fdr034
   de Waard AKM, 2018, EUR J PREV CARDIOL, V25, P1326, DOI 10.1177/2047487318780751
   Denollet J, 2005, PSYCHOSOM MED, V67, P89, DOI 10.1097/01.psy.0000149256.81953.49
   Dunn P, 2019, INT J CARDIOL, V293, P294, DOI 10.1016/j.ijcard.2019.06.039
   Ganesh SK, 2013, CIRCULATION, V128, P2813, DOI 10.1161/01.cir.0000437913.98912.1d
   Gorini A, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17176298
   Homko J, 2008, J CARDIOVASC NURS, V23, P332, DOI 10.1097/01.JCN.0000317432.44586.aa
   Jaspers NEM, 2020, EUR HEART J, V41, P1190, DOI 10.1093/eurheartj/ehz239
   Jennings C, 2017, EUR J PREV CARDIOL, V24, P77, DOI 10.1177/2047487317709118
   Kambhampati S, 2016, CURR CARDIOL REP, V18, DOI 10.1007/s11886-016-0729-6
   Koochek A, 2008, EUR J CARDIOV PREV R, V15, P78, DOI 10.1097/HJR.0b013e3282f21968
   Kroenke K, 2009, PSYCHOSOMATICS, V50, P613, DOI 10.1176/appi.psy.50.6.613
   Lee HY, 2015, AM J MENS HEALTH, V9, P370, DOI 10.1177/1557988314545485
   Lloyd-Jones DM, 2010, CIRCULATION, V121, P586, DOI 10.1161/CIRCULATIONAHA.109.192703
   Lo Scalzo Alessandra., 2009, Health Systems in Transition
   Maclagan LC, 2015, CURR OPIN CARDIOL, V30, P518, DOI 10.1097/HCO.0000000000000210
   Magnani JW, 2018, CIRCULATION, V138, pE48, DOI 10.1161/CIR.0000000000000579
   Mann DM, 2007, CARDIOVASC DRUG THER, V21, P311, DOI 10.1007/s10557-007-6040-4
   MODESTI PA, 1995, AM J HYPERTENS, V8, P201, DOI 10.1016/0895-7061(94)00189-I
   Modesti PA, 2014, J CARDIOVASC MED, V15, P683, DOI 10.2459/JCM.0000000000000069
   Pennant M, 2010, AM J EPIDEMIOL, V172, P501, DOI 10.1093/aje/kwq171
   Piepoli MF, 2016, ATHEROSCLEROSIS, V252, P207, DOI [10.1016/j.atherosclerosis.2016.05.037, 10.1177/2047487316653709]
   Sallis A, 2016, BMC FAM PRACT, V17, DOI 10.1186/s12875-016-0426-y
   Schultz WM, 2018, CIRCULATION, V137, P2166, DOI 10.1161/CIRCULATIONAHA.117.029652
   Timmis A, 2020, EUR HEART J, V41, P12, DOI 10.1093/eurheartj/ehz859
   Trummer U, 2017, EUR J PUBLIC HEALTH, V27, P590, DOI 10.1093/eurpub/ckx087
   van den Brekel-Dijkstra K, 2016, EUR J PREV CARDIOL, V23, P544, DOI 10.1177/2047487315591441
   van der Heide I, 2013, J HEALTH COMMUN, V18, P172, DOI 10.1080/10810730.2013.825668
   van der Leeuw J, 2014, EUR HEART J, V35, P837, DOI 10.1093/eurheartj/ehu004
   Van der Meer V, 2013, BMC FAM PRACT, V14, DOI 10.1186/1471-2296-14-29
   von Wagner C, 2007, J EPIDEMIOL COMMUN H, V61, P1086, DOI 10.1136/jech.2006.053967
   Walli-Attaei M, 2020, LANCET, V396, P97, DOI 10.1016/S0140-6736(20)30543-2
   Weintraub WS, 2011, CIRCULATION, V124, P967, DOI 10.1161/CIR.0b013e3182285a81
   Yusuf S, 2020, LANCET, V395, P795, DOI 10.1016/S0140-6736(19)32008-2
NR 51
TC 1
Z9 1
U1 0
U2 0
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD MAY
PY 2022
VL 32
IS 5
BP 1110
EP 1120
DI 10.1016/j.numecd.2022.01.013
EA APR 2022
PG 11
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 3F0TG
UT WOS:000830386000004
PM 35260313
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Zhang, SW
   Lin, JT
AF Zhang, Shuwen
   Lin, Jiangtao
TI Association of circadian syndrome and lung health: A population-based
   cohort study
SO RESPIRATORY MEDICINE
LA English
DT Article
DE Circadian syndrome; Chronic respiratory diseases; Respiratory symptoms;
   Lung function; Metabolic syndrome
ID METABOLIC SYNDROME; ATOPIC-DERMATITIS; ASTHMA; CLOCK; DEPRESSION;
   INFLAMMATION; PREVALENCE; MORTALITY; RECEPTOR; PROTEIN
AB Background: Few studies have explored the association between circadian syndrome (CircS) and lung health. Objective: To assess the relationship between CircS and lung health. Methods: This prospective cohort study enrolled 6252 adults. Multivariable logistic and linear regression models were employed to examine the association between CircS and the prevalence of chronic lung disease, respiratory symptoms, and lung function, as appropriate. Receiver operating characteristic curve analysis was used to compare the predictive power of the number of metabolic syndrome (MetS) and CircS components for lung health. Kaplan-Meier survival and multiple Cox regression analyses were used to assess the relationship between CircS and all-cause mortality. The effects of CircS on health-related quality of life (HQL) and health care use were also evaluated. Results: Participants with CircS were significantly associated with a higher prevalence of asthma, chronic bronchitis, cough, wheeze, phlegm production, and exertional dyspnea. The number of CircS components demonstrated better predictive power for the prevalence of asthma, chronic bronchitis, emphysema, cough, wheeze, phlegm production, and exertional dyspnea than the number of MetS components. Higher numbers of CircS components were significantly associated with decreased forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC), worse HQL, and increased health care use. Longitudinally, participants with CircS exhibited a higher risk of all-cause mortality than those without CircS. Conclusions: Our results support the claim of that CircS is a better predictor of lung health than the MetS in adults in the United States. Elevated CircS levels are associated with poorer lung function, increased health care use, worse HQL, and a higher risk of mortality.
C1 [Zhang, Shuwen] Peking Univ, Grad Sch, China Japan Friendship Sch Clin Med, Beijing 100029, Peoples R China.
   [Zhang, Shuwen; Lin, Jiangtao] China Japan Friendship Hosp, Ctr Resp Med, Dept Pulm & Crit Care Med, Beijing 100029, Peoples R China.
C3 Peking University; China-Japan Friendship Hospital
RP Lin, JT (corresponding author), China Japan Friendship Hosp, Ctr Resp Med, Dept Resp & Crit Care Med, Beijing 100029, Peoples R China.
EM jiangtao_l@263.net
RI Lin, Jiangtao/AAF-3565-2020; Zhang, Shuwen/LPP-3655-2024
FU National Natural Science Foundation of China [8217010602]
FX This work was supported by the National Natural Science Foundation of
   China (8217010602) .
CR [Anonymous], NATL HLTH NUTR EXAMI
   [Anonymous], 2023, EClinicalMedicine, V59
   Baffi CW, 2016, CHEST, V149, P1525, DOI 10.1016/j.chest.2015.12.034
   Cavaillés A, 2013, EUR RESPIR REV, V22, P454, DOI 10.1183/09059180.00008612
   Chen HC, 2021, J ASTHMA ALLERGY, V14, P371, DOI 10.2147/JAA.S302508
   Choi JH, 2017, ASIAN PAC J ALLERGY, V35, P150, DOI 10.12932/AP0772
   Cirillo DJ, 2002, AM J EPIDEMIOL, V155, P842, DOI 10.1093/aje/155.9.842
   Ding L, 2024, FRONT PHYSIOL, V15, DOI 10.3389/fphys.2024.1301450
   Durrington HJ, 2020, EUR RESPIR J, V56, DOI 10.1183/13993003.02407-2019
   Egede LE, 2002, DIABETES CARE, V25, P464, DOI 10.2337/diacare.25.3.464
   Ehlers A, 2018, MUCOSAL IMMUNOL, V11, P97, DOI 10.1038/mi.2017.24
   Giri A, 2022, TRENDS MOL MED, V28, P513, DOI 10.1016/j.molmed.2022.04.002
   Gu YF, 2024, FRONT ENDOCRINOL, V15, DOI 10.3389/fendo.2024.1379130
   Han YY, 2016, J ALLER CL IMM-PRACT, V4, P68, DOI 10.1016/j.jaip.2015.10.004
   Hankinson JL, 1999, AM J RESP CRIT CARE, V159, P179, DOI 10.1164/ajrccm.159.1.9712108
   Hu ZG, 2021, SLEEP BREATH, V25, P493, DOI 10.1007/s11325-020-02081-6
   Hui WS, 2010, EUR J EPIDEMIOL, V25, P375, DOI 10.1007/s10654-010-9459-z
   Hwang JW, 2014, FASEB J, V28, P176, DOI 10.1096/fj.13-232629
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   Li WZ, 2023, JMIR PUBLIC HLTH SUR, V9, DOI 10.2196/44073
   Lipovec NC, 2016, COPD, V13, P399, DOI 10.3109/15412555.2016.1140732
   Mcdonald VM, 2024, J ALLER CL IMM-PRACT, V12, P824, DOI 10.1016/j.jaip.2024.01.020
   Meghji J, 2021, LANCET, V397, P928, DOI 10.1016/S0140-6736(21)00458-X
   Miller MR, 2005, EUR RESPIR J, V26, P319, DOI 10.1183/09031936.05.00034805
   Neeland IJ, 2024, NAT REV DIS PRIMERS, V10, DOI 10.1038/s41572-024-00563-5
   Nosal C, 2020, ANNU REV PHYSIOL, V82, P391, DOI 10.1146/annurev-physiol-021119-034602
   Oda E, 2006, DIABETES CARE, V29, P2566, DOI 10.2337/dc06-1453
   Papaioannou AI, 2013, EUR RESPIR J, V41, P815, DOI 10.1183/09031936.00013112
   Pooler A, 2014, INT J CHRONIC OBSTR, V9, P315, DOI 10.2147/COPD.S53255
   Ran JY, 2024, J NUTR HEALTH AGING, V28, DOI 10.1016/j.jnha.2023.100011
   Reaven GM, 2011, J INTERN MED, V269, P127, DOI 10.1111/j.1365-2796.2010.02325.x
   Ruan ZS, 2023, FRONT MED-LAUSANNE, V10, DOI 10.3389/fmed.2023.1108663
   Serafino-Agrusa L, 2015, WORLD J CLIN CASES, V3, P285, DOI 10.12998/wjcc.v3.i3.285
   Shan ZL, 2019, JAMA-J AM MED ASSOC, V322, P1178, DOI 10.1001/jama.2019.13771
   Shi Y, 2012, AM J RESP CRIT CARE, V186, P412, DOI 10.1164/rccm.201111-2023OC
   Shi Z, 2021, J INTERN MED, V289, P851, DOI 10.1111/joim.13204
   Shi Z., 2022, Nutrients, V14
   Sun LR, 2024, AGING CLIN EXP RES, V36, DOI 10.1007/s40520-024-02745-3
   Sundar IK, 2017, BIOCHEM BIOPH RES CO, V493, P1390, DOI 10.1016/j.bbrc.2017.09.157
   Sundström J, 2006, BMJ-BRIT MED J, V332, P878, DOI 10.1136/bmj.38766.624097.1F
   Vasu VT, 2009, INTEGR CANCER THER, V8, P321, DOI 10.1177/1534735409352027
   Wang CY, 2023, J ALLER CL IMM-PRACT, V11, P1200, DOI 10.1016/j.jaip.2022.12.011
   Wang QX, 2021, JCI INSIGHT, V6, DOI 10.1172/jci.insight.145200
   Wang YL, 2022, FRONT NEUROL, V13, DOI 10.3389/fneur.2022.946172
   Wu TD, 2021, CHEST, V160, P1026, DOI 10.1016/j.chest.2021.03.056
   Xiao YF, 2023, BMC PUBLIC HEALTH, V23, DOI 10.1186/s12889-023-15934-y
   Xiao YF, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1137668
   Yao HW, 2015, AM J RESP CELL MOL, V53, P782, DOI 10.1165/rcmb.2014-0474OC
   Yohannes AM, 2014, EUR RESPIR REV, V23, P345, DOI 10.1183/09059180.00007813
   Zaslona Z, 2017, AM J PHYSIOL-LUNG C, V312, pL855, DOI 10.1152/ajplung.00072.2017
   Zhang L, 2019, CLIN EXP ALLERGY, V49, P770, DOI 10.1111/cea.13346
   Zimmet P, 2019, J INTERN MED, V286, P181, DOI 10.1111/joim.12924
NR 52
TC 0
Z9 0
U1 2
U2 2
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0954-6111
EI 1532-3064
J9 RESP MED
JI Respir. Med.
PD APR-MAY
PY 2025
VL 240
AR 108031
DI 10.1016/j.rmed.2025.108031
EA MAR 2025
PG 10
WC Cardiac & Cardiovascular Systems; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System
GA 0KF1V
UT WOS:001449337200001
PM 40058667
DA 2025-06-11
ER

PT J
AU Lang, F
   Huang, DY
   Vallon, V
AF Lang, Florian
   Huang, Dan Yang
   Vallon, Volker
TI SGK, renal function and hypertension
SO JOURNAL OF NEPHROLOGY
LA English
DT Article
DE Blood pressure; Coagulation; Fibrosis; Inflammation; Obesity
ID INDUCIBLE KINASE SGK1; PROTEIN-KINASE; MICE LACKING; BLOOD-PRESSURE;
   SGK1-KNOCKOUT MOUSE; ENAC ACTIVITY; SERUM; SALT; ALDOSTERONE; RETENTION
AB Serum- and glucocorticoid-inducible kinase 1 (SGK1) is expressed following cell stress and exposure to a variety of hormones including glucocorticoids and mineralocorticoids. It is activated by insulin and growth factors via phosphatidylinositol-3-kinase and the 3-phosphoinositide-dependent kinase PDK1. SGK1 enhances the activity of a variety of ion channels such as ENaC, TRPV5, ROMK, KCNE1/KCNQ1 and ClCKb; carriers such as NHE3, NKCC2, NCC and SGLT1; as well as the Na(+)/K(+)-ATPase. SGK1 contributes to Na(+) retention and K(+) elimination of the kidney as well as mineralocorticoid stimulation of salt appetite. A certain SGK1 gene variant (combined polymorphisms in intron 6 [I6CC] and in exon 8 [E8CC/CT]) is associated with moderately enhanced blood pressure. The SGK1 gene variant has been shown to affect 3%-5% of whites and some 10% of Africans. The gene variant sensitizes the carriers to the hypertensive effects of hyperinsulinemia. Moreover, the SGK1 gene variant is associated with increased body mass index, presumably a result of enhanced SGLT1 activity with accelerated intestinal glucose absorption. Obesity predisposes the carriers of the gene variant to development of type 2 diabetes. Moreover, SGK1 stimulates coagulation. Thus, SGK1 may participate in the pathogenesis of metabolic syndrome or syndrome X, a condition characterized by the coincidence of essential hypertension, procoagulant state, obesity, insulin resistance and hyperinsulinemia.
C1 [Lang, Florian] Univ Tubingen, Dept Physiol, DE-72076 Tubingen, Germany.
   [Huang, Dan Yang] Univ Tubingen, Dept Pharmacol, DE-72076 Tubingen, Germany.
   [Vallon, Volker] Univ Calif San Diego, Dept Med, VA San Diego Healthcare Syst, San Diego, CA 92103 USA.
   [Vallon, Volker] Univ Calif San Diego, Dept Pharmacol, VA San Diego Healthcare Syst, San Diego, CA 92103 USA.
C3 Eberhard Karls University of Tubingen; Eberhard Karls University of
   Tubingen; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA San Diego Healthcare System; University of
   California System; University of California San Diego; University of
   California System; University of California San Diego; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); VA San Diego
   Healthcare System
RP Lang, F (corresponding author), Univ Tubingen, Dept Physiol, Gmelinstr 5, DE-72076 Tubingen, Germany.
EM florian.lang@uni-tuebingen.de
OI Vallon, Volker/0000-0002-9211-2063
FU NHLBI NIH HHS [R01 HL094728, HL094728] Funding Source: Medline; NIDDK
   NIH HHS [P30DK079337, R01DK56248, R01 DK056248, P30 DK079337] Funding
   Source: Medline; NIGMS NIH HHS [GM66232, R01 GM066232] Funding Source:
   Medline
CR Ackermann D, 2007, HEPATOLOGY, V46, P173, DOI 10.1002/hep.21699
   Ackermann TF, 2009, AM J PHYSIOL-RENAL, V296, pF859, DOI 10.1152/ajprenal.90238.2008
   Arteaga MF, 2005, AM J PHYSIOL-RENAL, V289, pF90, DOI 10.1152/ajprenal.00390.2004
   Artunc F, 2008, PFLUG ARCH EUR J PHY, V456, P425, DOI 10.1007/s00424-007-0401-5
   Artunc F, 2009, KIDNEY BLOOD PRESS R, V32, P119, DOI 10.1159/000214439
   Artunc F, 2008, AM J PHYSIOL-RENAL, V295, pF1624, DOI 10.1152/ajprenal.00032.2008
   Artune F, 2006, J MOL MED, V84, P737, DOI 10.1007/s00109-006-0082-0
   BelAiba RS, 2006, CIRC RES, V98, P828, DOI 10.1161/01.RES.0000210539.54861.27
   Boehmer C, 2008, CELL PHYSIOL BIOCHEM, V22, P705, DOI 10.1159/000185554
   Boehmer C, 2008, CELL PHYSIOL BIOCHEM, V22, P591, DOI 10.1159/000185543
   Boini KM, 2008, KIDNEY BLOOD PRESS R, V31, P280, DOI 10.1159/000151666
   Ellison DH, 2009, J CLIN INVEST, V119, P763, DOI 10.1172/JCI38835
   Fejes-Tóth G, 2008, AM J PHYSIOL-RENAL, V294, pF1298, DOI 10.1152/ajprenal.00579.2007
   Firestone GL, 2003, CELL PHYSIOL BIOCHEM, V13, P1, DOI 10.1159/000070244
   Gonzalez-Rodriguez E, 2007, KIDNEY INT, V71, P116, DOI 10.1038/sj.ki.5002018
   Huang DY, 2006, AM J PHYSIOL-RENAL, V291, pF1264, DOI 10.1152/ajprenal.00299.2005
   Huang DY, 2006, AM J PHYSIOL-REG I, V290, pR935, DOI 10.1152/ajpregu.00382.2005
   Huang DY, 2004, J AM SOC NEPHROL, V15, P885, DOI 10.1097/01.ASN.0000120368.59693.A8
   Lang F, 2006, PHYSIOL REV, V86, P1151, DOI 10.1152/physrev.00050.2005
   Lang F, 2009, CURR OPIN NEPHROL HY, V18, P439, DOI 10.1097/MNH.0b013e32832f125e
   Nagase M, 2008, CLIN EXP NEPHROL, V12, P233, DOI 10.1007/s10157-008-0034-9
   Nijenhuis T, 2005, J CLIN INVEST, V115, P1651, DOI 10.1172/JCI24134
   Rexhepaj R, 2008, AM J PHYSIOL-REG I, V294, pR2008, DOI 10.1152/ajpregu.00737.2007
   Rexhepaj R, 2006, PFLUG ARCH EUR J PHY, V453, P97, DOI 10.1007/s00424-006-0111-4
   Sandulache D, 2006, PFLUG ARCH EUR J PHY, V452, P444, DOI 10.1007/s00424-005-0021-x
   Schwab M, 2008, CELL PHYSIOL BIOCHEM, V21, P151, DOI 10.1159/000113757
   Shaw JR, 2008, CELL PHYSIOL BIOCHEM, V22, P69, DOI 10.1159/000149784
   Shibata S, 2007, HYPERTENSION, V49, P355, DOI 10.1161/01.HYP.0000255636.11931.a2
   STIER CT, 1986, ANNU REV PHARMACOL, V26, P101
   Vallon V, 2005, AM J PHYSIOL-REG I, V289, pR395, DOI 10.1152/ajpregu.00731.2004
   Vallon V, 2009, AM J PHYSIOL-RENAL, V297, pF704, DOI 10.1152/ajprenal.00030.2009
   von Wowern F, 2005, KIDNEY INT, V68, P2164, DOI 10.1111/j.1523-1755.2005.00672.x
   Waldegger S, 1997, P NATL ACAD SCI USA, V94, P4440, DOI 10.1073/pnas.94.9.4440
   Wulff P, 2002, J CLIN INVEST, V110, P1263, DOI 10.1172/JCI200215696
NR 34
TC 25
Z9 30
U1 0
U2 2
PU WICHTIG EDITORE
PI MILAN
PA 72/74 VIA FRIULI, 20135 MILAN, ITALY
SN 1121-8428
J9 J NEPHROL
JI J. Nephrol.
PD NOV-DEC
PY 2010
VL 23
SU 16
SI SI
BP S124
EP S129
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 740XT
UT WOS:000288828400017
PM 21170869
DA 2025-06-11
ER

PT J
AU Rinkevich, D
   Belcik, T
   Gupta, NC
   Cannard, E
   Alkayed, NJ
   Kaul, S
AF Rinkevich, Diana
   Belcik, Todd
   Gupta, Nandita C.
   Cannard, Elizabeth
   Alkayed, Nabil J.
   Kaul, Sanjiv
TI Coronary Autoregulation Is Abnormal in Syndrome X: Insights Using
   Myocardial Contrast Echocardiography
SO JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
LA English
DT Article
DE Syndrome X; Myocardial contrast echocardiography; Coronary
   autoregulation
ID SYNDROME EVALUATION WISE; BLOOD-FLOW RESERVE; CARDIAC SYNDROME-X;
   CHEST-PAIN; ARTERY-DISEASE; ANGINA-PECTORIS; NATIONAL-HEART; WOMEN;
   PERFUSION; ISCHEMIA
AB Background: Syndrome X in women is thought to be caused by coronary microvascular dysfunction, the exact site of which is unknown. The aim of this study was to characterize the microvascular site of dysfunction in these patients using myocardial contrast echocardiography.
   Methods: Women with exertional angina, positive test results on stress imaging, but no coronary artery disease (the study group, n = 18) and age-matched control women also with no coronary artery disease (n = 17) were enrolled. Myocardial contrast echocardiography was performed at rest and during dipyridamole-induced hyperemia. Mean microbubble velocity (beta) and myocardial blood volume (A) were measured, and myocardial blood flow (A . beta) was computed. In addition, plasma concentrations of eicosanoids, female sex hormones, and C-reactive protein were measured.
   Results: Rest beta and myocardial blood flow (A . beta) were higher in the study compared with the control women (1.61 +/- 0.68 vs 0.74 +/- 0.44, P = .0001, and 157 +/- 121 vs 54 +/- 54, P = 0.0001, respectively) despite similar heart rates and systolic blood pressures. After the administration of dipyridamole, whereas the changes in A and A . beta were not significantly different between the two groups, beta reserve (the ratio of stress beta to rest beta) was markedly lower in the study group (1.48 +/- 0.62 vs 2.78 +/- 0.94, P = .0001). Blood hematocrit, eicosanoids, female sex hormones, glucose, and C-reactive protein were not different between the two groups.
   Conclusions: Coronary autoregulation is abnormal in patients with syndrome X (higher resting beta and myocardial blood flow and lower beta reserve), which suggests that the coronary resistance vessels are the site of microvascular abnormality. (J Am Soc Echocardiogr 2013;26:290-6.)
C1 [Rinkevich, Diana; Belcik, Todd; Gupta, Nandita C.; Cannard, Elizabeth; Alkayed, Nabil J.; Kaul, Sanjiv] Oregon Hlth & Sci Univ, Knight Cardiovasc Inst, Portland, OR 97239 USA.
C3 Oregon Health & Science University
RP Kaul, S (corresponding author), Oregon Hlth & Sci Univ, Knight Cardiovasc Inst, 3181 SW Sam Jackson Pk Rd,UHN 62, Portland, OR 97239 USA.
EM kauls@ohsu.edu
FU Bechen Family Foundation; Alpha Phi Foundation (Portland, OR); National
   Institutes of Health (Bethesda, MD) [R01 NS44313, NS070837,
   PO1-HD034430]
FX This study was supported in part by grants to Dr. Rinkevich from the
   Bechen Family Foundation and the Alpha Phi Foundation (Portland, OR) and
   grants R01 NS44313 and NS070837 to Dr. Alkayed and PO1-HD034430 to Dr.
   Kaul from the National Institutes of Health (Bethesda, MD).
CR Bin JP, 2006, CIRCULATION, V113, P2502, DOI 10.1161/CIRCULATIONAHA.106.627091
   Bugiardini R, 2004, CIRCULATION, V109, P2518, DOI 10.1161/01.CIR.0000128208.22378.E3
   CANNON RO, 1983, J AM COLL CARDIOL, V1, P1359, DOI 10.1016/S0735-1097(83)80037-0
   CANNON RO, 1988, AM J CARDIOL, V61, P1338, DOI 10.1016/0002-9149(88)91180-0
   CAPDEVILA JH, 1992, FASEB J, V6, P731, DOI 10.1096/fasebj.6.2.1537463
   Fletcher RH., 1988, Clinical Epidemiology The Essentials
   Gaibazzi N, 2011, AM J CARDIOL, V108, P973, DOI 10.1016/j.amjcard.2011.05.030
   GALASSI AR, 1993, AM J CARDIOL, V72, P134, DOI 10.1016/0002-9149(93)90148-6
   Gupta N, 2011, CIRCULATION, V124
   HARDER DR, 1995, J VASC RES, V32, P79, DOI 10.1159/000159080
   Jayaweera AR, 1999, AM J PHYSIOL-HEART C, V277, pH2363, DOI 10.1152/ajpheart.1999.277.6.H2363
   Johnson BD, 2004, CIRCULATION, V109, P2993, DOI 10.1161/01.CIR.0000130642.79868.B2
   Kaski JC, 2002, CARDIOVASC RES, V53, P620, DOI 10.1016/S0008-6363(01)00460-6
   KASSAB GS, 1994, AM J PHYSIOL, V267, pH319, DOI 10.1152/ajpheart.1994.267.1.H319
   KASSAB GS, 1994, AM J PHYSIOL-HEART C, V267, pH2100, DOI 10.1152/ajpheart.1994.267.6.H2100
   KASSAB GS, 1993, AM J PHYSIOL, V265, pH350, DOI 10.1152/ajpheart.1993.265.1.H350
   Kaul S, 2008, J AM COLL CARDIOL, V52, P1399, DOI 10.1016/j.jacc.2008.07.039
   Kaul S, 2012, J ECHOCARDIOGR, V10, P1, DOI 10.1007/s12574-011-0100-2
   Kemp H G, 1967, Trans Assoc Am Physicians, V80, P59
   KEMP HG, 1986, J AM COLL CARDIOL, V7, P479, DOI 10.1016/S0735-1097(86)80456-9
   Le DE, 2002, J AM SOC ECHOCARDIOG, V15, P857, DOI 10.1067/mje.2002.121275
   Le DE, 2012, J AM COLL CARDIOL, V59, pA103
   Lindner JR, 2002, J AM SOC ECHOCARDIOG, V15, P396, DOI 10.1067/mje.2002.117290
   Linka AZ, 1998, CIRCULATION, V98, P1912, DOI 10.1161/01.CIR.98.18.1912
   Oltman CL, 1998, CIRC RES, V83, P932
   OPHERK D, 1981, CIRCULATION, V63, P817, DOI 10.1161/01.CIR.63.4.817
   Panting JR, 2002, NEW ENGL J MED, V346, P1948, DOI 10.1056/NEJMoa012369
   PAPANICOLAOU MN, 1986, AM J CARDIOL, V58, P1181, DOI 10.1016/0002-9149(86)90378-4
   Pitts WR, 1997, AM J CARDIOL, V80, P1086, DOI 10.1016/S0002-9149(97)00610-3
   Reis SE, 2001, AM HEART J, V141, P735, DOI 10.1067/mhj.2001.114198
   RICHARDSON PJ, 1974, LANCET, V2, P677
   Rim SJ, 2001, CIRCULATION, V104, P2704, DOI 10.1161/hc4701.099580
   Sestito A, 2011, J CARDIOVASC MED, V12, P322, DOI 10.2459/JCM.0b013e3283406479
   Srinivasan M, 2005, J AM COLL CARDIOL, V46, P42, DOI 10.1016/j.jacc.2005.03.056
   Trabold T, 2003, ROFO-FORTSCHR RONTG, V175, P1051
   Vogel R, 2005, J AM COLL CARDIOL, V45, P754, DOI 10.1016/j.jacc.2004.11.044
   von Mering GO, 2004, CIRCULATION, V109, P722, DOI 10.1161/01.CIR.0000115525.92645.16
   Wei K, 2001, CIRCULATION, V103, P2560
   Wei K, 1998, CIRCULATION, V97, P473
   Wei K, 1998, J AM COLL CARDIOL, V32, P252, DOI 10.1016/S0735-1097(98)00212-5
   Wong TY, 2002, JAMA-J AM MED ASSOC, V287, P1153, DOI 10.1001/jama.287.9.1153
   Zhang WR, 2008, STROKE, V39, P2073, DOI 10.1161/STROKEAHA.107.508325
NR 42
TC 29
Z9 36
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0894-7317
J9 J AM SOC ECHOCARDIOG
JI J. Am. Soc. Echocardiogr.
PD MAR
PY 2013
VL 26
IS 3
BP 290
EP 296
DI 10.1016/j.echo.2012.12.008
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 094US
UT WOS:000315290200012
PM 23313388
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Franckilin, LRD
   Dos Santos, ACPM
   Freitas, FEDA
   Vieira, IG
   Jorge, CED
   Neri, DG
   de Abreu, MVC
   Fonseca, JK
   Loffi, RG
   Foureaux, G
AF de Sousa Franckilin, Laryssa Rosa
   Dos Santos, Anna Clara Paiva Menezes
   Freitas, Flavio Eduardo Dias Araujo
   Vieira, Isabela Garbazza
   de Freitas Jorge, Carlos Eduardo
   Neri, Daniela Godoy
   de Abreu, Maria Vitoria Cota
   Fonseca, Janaina Koenen
   Loffi, Renato Guimaraes
   Foureaux, Giselle
TI Gluten: do only celiac patients benefit from its removal from the diet?
SO FOOD REVIEWS INTERNATIONAL
LA English
DT Review
DE Gluten; celiac disease; wheat allergy; non-celiac gluten sensitivity;
   gluten free diet
ID AUTISM SPECTRUM DISORDERS; BONE-MINERAL DENSITY; CASEIN-FREE DIET;
   LONG-TERM; NATIONAL-HEALTH; METABOLIC SYNDROME; GUT PERMEABILITY;
   DISEASE PATIENTS; DIABETES CONTROL; CONTROLLED TRIAL
AB Gluten is the most common protein in wheat and is related to different pathogeneses. There are three main gluten-related disorders: celiac disease (CD), wheat allergy (WA), and non-celiac gluten sensitivity (NCGS). Clinical manifestations are strictly related in all of them, such as abdominal pain and distention, however the development pathways may differ. The diagnosis criteria are also different, in CD features immunological markers such as IgA, while WA presents IgE markers, and NCGS does not have any specific immunological marker. The consumption of wheat, and consequently gluten-related products, is historical and it has grown over human evolution, which leads us to question what role this component plays in other diseases, and the consequence of a gluten-free diet (GFD). GFD is the treatment with major efficacy in CD and, likewise, is related with improvements in neuropathologies (autism spectrum disorder, anxiety, depression and schizophrenia), obesity, and the gut microbiome. Further investigation is required. GFD studies in people who do not present CD seem to be safe, especially when products containing gluten are not replaced by processed gluten-free products but by minimally processed foods, and also when the food strategy is accompanied by a qualified professional.
C1 [de Sousa Franckilin, Laryssa Rosa; Dos Santos, Anna Clara Paiva Menezes; Vieira, Isabela Garbazza; de Abreu, Maria Vitoria Cota; Foureaux, Giselle] Univ Fed Minas Gerais, Dept Morfol, Belo Horizonte, MG, Brazil.
   [Freitas, Flavio Eduardo Dias Araujo] Univ Fed Ouro Preto, Dept Ciencias Exatas & Biol ICEB, Ouro Preto, Brazil.
   [de Freitas Jorge, Carlos Eduardo; Foureaux, Giselle] Angiogold Med Integrat, Dept Nutr, Belo Horizonte, MG, Brazil.
   [Neri, Daniela Godoy; Fonseca, Janaina Koenen] Clin Med Integrada, Belo Horizonte, MG, Brazil.
   [Loffi, Renato Guimaraes] Treini Biotecnol Ltda, Dept Ciencia Tecnol & Inovacao, Belo Horizonte, MG, Brazil.
C3 Universidade Federal de Minas Gerais; Universidade Federal de Ouro Preto
RP Foureaux, G (corresponding author), Univ Fed Minas Gerais, BR-31270901 Belo Horizonte, MG, Brazil.
EM gifoureaux@yahoo.com.br
CR Addolorato G, 2001, SCAND J GASTROENTERO, V36, P502, DOI 10.1080/00365520119754
   Agarwal A, 2021, INTEST RES, V19, P106, DOI 10.5217/ir.2019.00136
   Akirov A, 2015, WORLD J DIABETES, V6, P707, DOI 10.4239/wjd.v6.i5.707
   Albrady A, 2018, ANN MED HEALTH SCI R, V8, P78
   Almeida LM, 2016, AUTOIMMUN DIS, V2016, DOI 10.1155/2016/5409653
   Altenbach SB, 2018, BMC PLANT BIOL, V18, DOI 10.1186/s12870-018-1506-z
   Athreya K, 2017, NUTR CANCER, V69, P1099, DOI 10.1080/01635581.2017.1362445
   Aufiero VR, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700854
   Aziz I, 2014, EUR J GASTROEN HEPAT, V26, P33, DOI 10.1097/01.meg.0000435546.87251.f7
   Bai JC, 2017, J CLIN GASTROENTEROL, V51, P755, DOI 10.1097/MCG.0000000000000919
   Balakireva AV, 2016, NUTRIENTS, V8, DOI 10.3390/nu8100644
   Barbaro Maria Raffaella, 2018, F1000Res, V7, DOI 10.12688/f1000research.15849.1
   Barcia G, 2008, J AUTISM DEV DISORD, V38, P407, DOI 10.1007/s10803-007-0480-3
   Barone M, 2016, EUR J CLIN NUTR, V70, P23, DOI 10.1038/ejcn.2015.114
   Bascuñán KA, 2017, EUR J NUTR, V56, P449, DOI 10.1007/s00394-016-1238-5
   Baspinar B, 2020, EURASIAN J MED, V52, P292, DOI 10.5152/eurasianjmed.2020.19230
   BATTISTELLA PA, 1987, CEPHALALGIA, V7, P125, DOI 10.1046/j.1468-2982.1987.0702125.x
   Bayrak NA, 2020, J PEDIATR ENDOCR MET, V33, P409, DOI 10.1515/jpem-2019-0378
   Bender L, 1953, PSYCHIAT QUART, V27, P663, DOI 10.1007/BF01562517
   Benito-Garcia F, 2019, EXPERT REV CLIN IMMU, V15, P849, DOI 10.1080/1744666X.2019.1642747
   Berry N, 2018, JGH OPEN, V2, P196, DOI 10.1002/jgh3.12073
   Bonder MJ, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0295-y
   Brant A, 2007, CURR OPIN ALLERGY CL, V7, P152, DOI 10.1097/ACI.0b013e328042ba77
   Bressan P, 2016, FRONT HUM NEUROSCI, V10, DOI 10.3389/fnhum.2016.00130
   Briani C, 2008, AUTOIMMUN REV, V7, P644, DOI 10.1016/j.autrev.2008.05.006
   Brisman J, 2002, OCCUP ENVIRON MED, V59, P498, DOI 10.1136/oem.59.7.498
   Bromilow S, 2017, J PROTEOMICS, V163, P67, DOI 10.1016/j.jprot.2017.03.026
   Bulka CM, 2017, EPIDEMIOLOGY, V28, pE24, DOI 10.1097/EDE.0000000000000640
   Bushara KO, 2005, GASTROENTEROLOGY, V128, pS92, DOI 10.1053/j.gastro.2005.02.018
   Cabrera-Chávez F, 2017, NUTRIENTS, V9, DOI 10.3390/nu9010081
   Caio G, 2020, DIGEST LIVER DIS, V52, P130, DOI 10.1016/j.dld.2019.11.010
   Cappello M, 2016, CLIN MED INSIGHTS-GA, V9, DOI 10.4137/CGast.S38454
   Carlsson AK, 2001, PEDIATRICS, V107, P42, DOI 10.1542/peds.107.1.42
   Cassisi JE, 2020, J CLIN PSYCHOL MED S, V27, P444, DOI 10.1007/s10880-020-09698-5
   Castillo NE, 2015, GASTROENTEROL REP, V3, P3, DOI 10.1093/gastro/gou065
   Castro-Antunes MM, 2011, CLINICS, V66, P227
   Catassi C, 2015, NUTRIENTS, V7, P4966, DOI 10.3390/nu7064966
   Catassi C, 2014, J PEDIATR GASTR NUTR, V59, pS7, DOI 10.1097/01.mpg.0000450393.23156.59
   Chakravarthi SD, 2012, INDIAN J GASTROENTER, V31, P165, DOI 10.1007/s12664-012-0216-y
   Chen X, 2015, J BIOL CHEM, V290, P21365, DOI 10.1074/jbc.M115.669895
   Cheng JF, 2010, J CLIN GASTROENTEROL, V44, P267, DOI 10.1097/MCG.0b013e3181b7ed58
   Choung RS, 2020, J CLIN GASTROENTEROL, V54, P620, DOI 10.1097/MCG.0000000000001277
   Choung RS, 2017, MAYO CLIN PROC, V92, P30, DOI 10.1016/j.mayocp.2016.10.012
   Cianferoni Antonella, 2016, J Asthma Allergy, V9, P13, DOI 10.2147/JAA.S81550
   Cielinska A., 2017, HSOA J CLIN IMMUNOL, V3, P1, DOI [10.24966/CIIT-8844/100009, DOI 10.24966/CIIT-8844/100009]
   COOPER BT, 1980, GASTROENTEROLOGY, V79, P801
   D'Ovidio R, 2004, J CEREAL SCI, V39, P321, DOI 10.1016/j.jcs.2003.12.002
   Moreno MD, 2017, NUTRIENTS, V9, DOI 10.3390/nu9010046
   de Oliveira EP, 2014, SPORTS MED, V44, P79, DOI 10.1007/s40279-014-0153-2
   Deora V, 2017, J PEDIATR GASTR NUTR, V65, P185, DOI 10.1097/MPG.0000000000001475
   Di Sabatino A, 2015, CLIN GASTROENTEROL H, V13, P1604, DOI 10.1016/j.cgh.2015.01.029
   DICKE W K, 1953, Acta Paediatr, V42, P34, DOI 10.1111/j.1651-2227.1953.tb05563.x
   Digiacomo DV, 2013, SCAND J GASTROENTERO, V48, P921, DOI 10.3109/00365521.2013.809598
   DOHAN FC, 1984, BIOL PSYCHIAT, V19, P385
   Dowd AJ, 2020, DIGIT HEALTH, V6, DOI 10.1177/2055207620903627
   Drago S, 2006, SCAND J GASTROENTERO, V41, P408, DOI 10.1080/00365520500235334
   Eaton WW, 2015, AM J PSYCHIAT, V172, P219, DOI 10.1176/appi.ajp.2014.14040550
   Ehteshami Mehdi, 2018, Asian Pac J Cancer Prev, V19, P2979, DOI 10.22034/APJCP.2018.19.10.2979
   Elder JH, 2006, J AUTISM DEV DISORD, V36, P413, DOI 10.1007/s10803-006-0079-0
   Elli L, 2016, NUTRIENTS, V8, DOI 10.3390/nu8020084
   Elli L, 2015, WORLD J GASTROENTERO, V21, P7110, DOI 10.3748/wjg.v21.i23.7110
   Emery CF, 2017, PAIN, V158, P273, DOI 10.1097/j.pain.0000000000000754
   Fasano A, 2003, ARCH INTERN MED, V163, P286, DOI 10.1001/archinte.163.3.286
   Fasano A, 2003, GUT, V52, P168, DOI 10.1136/gut.52.2.168
   Fasano A, 2011, PHYSIOL REV, V91, P151, DOI 10.1152/physrev.00003.2008
   Gaesser GA, 2012, J ACAD NUTR DIET, V112, P1330, DOI 10.1016/j.jand.2012.06.009
   Gandolfi L, 2000, AM J GASTROENTEROL, V95, P689, DOI 10.1111/j.1572-0241.2000.01847.x
   Gevers D, 2014, CELL HOST MICROBE, V15, P382, DOI 10.1016/j.chom.2014.02.005
   Ghalichi F, 2016, WORLD J PEDIATR, V12, P436, DOI 10.1007/s12519-016-0040-z
   Gisolfi CV, 2000, NEWS PHYSIOL SCI, V15, P114
   Green PHR, 2007, NEW ENGL J MED, V357, P1731, DOI 10.1056/NEJMra071600
   Green PHR, 2015, J ALLERGY CLIN IMMUN, V135, P1099, DOI 10.1016/j.jaci.2015.01.044
   Guandalini S, 2014, JAMA PEDIATR, V168, P272, DOI 10.1001/jamapediatrics.2013.3858
   Haberman Y, 2014, J CLIN INVEST, V124, P3617, DOI 10.1172/JCI75436
   Hadjivassiliou M, 2017, NEUROLOGY, V89, P705, DOI [10.1212/WNL.0000000000004237, 10.1212/wnl.0000000000004237]
   Haimoto H, 2012, DIABETES METAB SYNDR, V5, P283, DOI 10.2147/DMSO.S34306
   Halfdanarson TR, 2007, BLOOD, V109, P412, DOI 10.1182/blood-2006-07-031104
   Harnett JE, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-58236-8
   Heckers S, 2015, SCHIZOPHR RES, V167, P4, DOI 10.1016/j.schres.2014.09.041
   Hindiyeh N, 2015, CURR PAIN HEADACHE R, V19, DOI 10.1007/s11916-015-0501-4
   Hollon J, 2015, NUTRIENTS, V7, P1565, DOI 10.3390/nu7031565
   Hovell CJ, 2001, MED J AUSTRALIA, V175, P247, DOI 10.5694/j.1326-5377.2001.tb143555.x
   Husby S, 2012, J PEDIATR GASTR NUTR, V54, P136, DOI 10.1097/MPG.0b013e31821a23d0
   Imperatore N, 2018, J GASTROENTEROL, V53, P507, DOI 10.1007/s00535-017-1381-7
   Inomata N, 2009, CURR OPIN ALLERGY CL, V9, P238, DOI 10.1097/ACI.0b013e32832aa5bc
   Isolauri E, 1996, J ALLERGY CLIN IMMUN, V97, P9, DOI 10.1016/S0091-6749(96)70277-4
   Jahromi SR, 2019, J HEADACHE PAIN, V20, DOI 10.1186/s10194-019-1057-1
   Jamieson JA, 2019, NUTR RES, V66, P107, DOI 10.1016/j.nutres.2019.02.005
   Johnston SD, 1998, QJM-MON J ASSOC PHYS, V91, P853, DOI 10.1093/qjmed/91.12.853
   Kabbani TCA, 2014, AM J GASTROENTEROL, V109, P741, DOI 10.1038/ajg.2014.41
   Kårhus LL, 2019, UNITED EUR GASTROENT, V7, P78, DOI 10.1177/2050640618811485
   Katz KD, 2011, AM J GASTROENTEROL, V106, P1333, DOI 10.1038/ajg.2011.21
   Kim HS, 2017, DIGEST DIS SCI, V62, P2440, DOI 10.1007/s10620-017-4583-1
   Kim HS, 2016, JAMA INTERN MED, V176, P1716, DOI 10.1001/jamainternmed.2016.5254
   Kraft BD, 2009, NUTR METAB, V6, DOI 10.1186/1743-7075-6-10
   Kuloglu Z, 2009, YONSEI MED J, V50, P617, DOI 10.3349/ymj.2009.50.5.617
   Kupfer Sonia S, 2012, Gastrointest Endosc Clin N Am, V22, P639, DOI 10.1016/j.giec.2012.07.003
   Lachin JM, 2014, DIABETES, V63, P739, DOI 10.2337/db13-0881
   Laszkowska M, 2018, CLIN GASTROENTEROL H, V16, P295, DOI 10.1016/j.cgh.2017.07.042
   Leeds JS, 2011, DIABETES CARE, V34, P2158, DOI 10.2337/dc11-0149
   Leonard MM, 2014, CLIN EXP GASTROENTER, V7, P25, DOI 10.2147/CEG.S54567
   Lerner A, 2019, FRONT PEDIATR, V7, DOI 10.3389/fped.2019.00414
   Lerner A, 2015, NUTR REV, V73, P544, DOI 10.1093/nutrit/nuv011
   Lerner A, 2012, CLIN REV ALLERG IMMU, V42, P322, DOI 10.1007/s12016-010-8237-8
   Lerner BA, 2019, DIGEST DIS SCI, V64, P1740, DOI 10.1007/s10620-019-05663-x
   Levinta A, 2018, ADV NUTR, V9, P824, DOI 10.1093/advances/nmy056
   Lichtwark IT, 2014, ALIMENT PHARM THER, V40, P160, DOI 10.1111/apt.12809
   Lionetti E, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010143
   Lionetti E, 2015, NUTRIENTS, V7, P5532, DOI 10.3390/nu7075235
   Lionetti E, 2014, NEW ENGL J MED, V371, P1295, DOI 10.1056/NEJMoa1400697
   Lis D, 2015, MED SCI SPORT EXER, V47, P2563, DOI 10.1249/MSS.0000000000000699
   Liu E, 2017, GASTROENTEROLOGY, V152, P1329, DOI 10.1053/j.gastro.2017.02.002
   Losowsky MS, 2008, DIGEST DIS, V26, P112, DOI 10.1159/000116768
   Ludvigsson JF, 2019, GASTROENTEROL CLIN N, V48, P1, DOI 10.1016/j.gtc.2018.09.004
   Maggioni M, 2016, FOOD RES INT, V88, P319, DOI 10.1016/j.foodres.2015.11.030
   Majamaa H, 1999, ALLERGY, V54, P346, DOI 10.1034/j.1398-9995.1999.00834.x
   Marasco G, 2020, NUTRIENTS, V12, DOI 10.3390/nu12092674
   Marí-Bauset S, 2014, J CHILD NEUROL, V29, P1718, DOI 10.1177/0883073814531330
   Matthias T, 2016, AUTOIMMUN REV, V15, P1111, DOI 10.1016/j.autrev.2016.09.011
   Mayer EA, 2015, J CLIN INVEST, V125, P926, DOI 10.1172/JCI76304
   McMillan SA, 1996, GUT, V39, P43, DOI 10.1136/gut.39.1.43
   Melini V, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010170
   Merck SF, 2017, NURS FORUM, V52, P298, DOI 10.1111/nuf.12202
   Miranda J, 2014, PLANT FOOD HUM NUTR, V69, P182, DOI 10.1007/s11130-014-0410-4
   Mormile R, 2014, INT J COLORECTAL DIS, V29, P1571, DOI 10.1007/s00384-014-1923-x
   Nachman F, 2010, DIGEST LIVER DIS, V42, P685, DOI 10.1016/j.dld.2010.03.004
   Neuman V, 2020, DIABETES OBES METAB, V22, P866, DOI 10.1111/dom.13974
   Newberry Carolyn, 2019, Curr Treat Options Gastroenterol, V17, P554, DOI 10.1007/s11938-019-00255-0
   Newberry Carolyn, 2017, Curr Gastroenterol Rep, V19, P54, DOI 10.1007/s11894-017-0597-2
   Newnham ED, 2016, J GASTROEN HEPATOL, V31, P342, DOI 10.1111/jgh.13060
   Niland Benjamin, 2018, Gastroenterol Hepatol (N Y), V14, P82
   O' Neill Daniel F, 2003, Metab Syndr Relat Disord, V1, P291, DOI 10.1089/1540419031361345
   Ortiz C, 2017, REV CHIL PEDIATR-CHI, V88, P417, DOI 10.4067/S0370-41062017000300017
   Parra-Medina R, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0124040
   Pekki H, 2015, AM J GASTROENTEROL, V110, P1078, DOI 10.1038/ajg.2015.155
   Peters M, 2020, J HUM NUTR DIET, V33, P453, DOI 10.1111/jhn.12728
   Picarelli A, 2016, J CLIN GASTROENTEROL, V50, P849, DOI 10.1097/MCG.0000000000000515
   Soares FLP, 2013, J NUTR BIOCHEM, V24, P1105, DOI 10.1016/j.jnutbio.2012.08.009
   Poole JA, 2006, PEDIATRICS, V117, P2175, DOI 10.1542/peds.2005-1803
   Pruimboom L, 2015, J HEALTH POPUL NUTR, V33, DOI 10.1186/s41043-015-0032-y
   Pynnönen PA, 2005, BMC PSYCHIATRY, V5, DOI 10.1186/1471-244X-5-14
   Ravikumara M, 2007, J PEDIATR GASTR NUTR, V45, P497, DOI 10.1097/MPG.0b013e31812e5710
   Reilly NR, 2016, J PEDIATR-US, V175, P206, DOI 10.1016/j.jpeds.2016.04.014
   Remes-Troche J, 2020, REV GASTROENTEROL ME, V85, P109, DOI 10.1016/j.rgmx.2019.02.002
   Rondanelli M, 2018, NUTR RES REV, V31, P131, DOI [10.1017/S0954422417000270, 10.1017/s0954422417000270]
   Roszkowska A, 2019, MEDICINA-LITHUANIA, V55, DOI 10.3390/medicina55060222
   Rubenstein E, 2018, AUTISM RES, V11, P185, DOI 10.1002/aur.1896
   Saad K, 2015, CLIN PSYCHOPHARM NEU, V13, P188, DOI 10.9758/cpn.2015.13.2.188
   Saibeni S, 2005, CLIN GASTROENTEROL H, V3, P574, DOI 10.1016/S1542-3565(05)00022-4
   Sampson HA, 2000, J PEDIATR GASTR NUTR, V30, pS87, DOI 10.1097/00005176-200001001-00013
   Sapone A, 2006, DIABETES, V55, P1443, DOI 10.2337/db05-1593
   Shahbazkhani B, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-59532-z
   Sharma A, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0152476
   Shukla R, 2015, DIGEST DIS SCI, V60, P2953, DOI 10.1007/s10620-015-3607-y
   Sicherer SH, 2014, J ALLERGY CLIN IMMUN, V133, P291, DOI 10.1016/j.jaci.2013.11.020
   Silano M, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2015-009163
   Silano M, 2009, CURR MED CHEM, V16, P1489, DOI 10.2174/092986709787909613
   Simmons JH, 2007, J PEDIATR-US, V150, P461, DOI 10.1016/j.jpeds.2006.12.046
   Simons F.J., 1981, Food, Nutrition, and Evolution: Food As an Environmental Factor in the Genesis of Human Variability, P179
   SJOBERG S, 1987, DIABETOLOGIA, V30, P208, DOI 10.1007/BF00270417
   Sollid LM, 2015, DIGEST DIS, V33, P115, DOI 10.1159/000369512
   Steffes MW, 2003, DIABETES CARE, V26, P832, DOI 10.2337/diacare.26.3.832
   Svensson J, 2016, SPRINGERPLUS, V5, DOI 10.1186/s40064-016-2641-3
   Takahashi M, 2000, JPN J PHARMACOL, V84, P259, DOI 10.1254/jjp.84.259
   Talley N.J., 2011, YEARB MED, V2011, P437, DOI [10.1016/S0084-3873(11)00316-6, DOI 10.1016/S0084-3873(11)00316-6]
   Tatham AS, 2008, CLIN EXP ALLERGY, V38, P1712, DOI 10.1111/j.1365-2222.2008.03101.x
   Tau C, 2006, EUR J CLIN NUTR, V60, P358, DOI 10.1038/sj.ejcn.1602323
   Thompson T, 2000, J AM DIET ASSOC, V100, P1389, DOI 10.1016/S0002-8223(00)00386-2
   Tikkakoski S, 2007, SCAND J GASTROENTERO, V42, P60, DOI 10.1080/00365520600789974
   Tokgöz Y, 2018, BMC PEDIATR, V18, DOI 10.1186/s12887-018-1107-x
   Tonutti E, 2014, AUTOIMMUN REV, V13, P472, DOI 10.1016/j.autrev.2014.01.043
   Tortora R, 2015, ALIMENT PHARM THER, V41, P352, DOI 10.1111/apt.13062
   Tortora R, 2018, NUTRIENTS, V10, DOI 10.3390/nu10091239
   Tortora R, 2016, SCAND J GASTROENTERO, V51, P1179, DOI 10.1080/00365521.2016.1186222
   Uhde M, 2016, GUT, V65, P1930, DOI 10.1136/gutjnl-2016-311964
   Urade Reiko, 2018, Biophys Rev, V10, P435, DOI 10.1007/s12551-017-0367-2
   Valletta E, 2010, EUR J CLIN NUTR, V64, P1371, DOI 10.1038/ejcn.2010.161
   van Bergen J, 2015, GASTROENTEROLOGY, V148, P1187, DOI 10.1053/j.gastro.2015.01.030
   van Gils T, 2016, NUTRIENTS, V8, DOI 10.3390/nu8110714
   van Hees NJM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0129640
   van Hees NJM, 2013, J PSYCHOSOM RES, V74, P155, DOI 10.1016/j.jpsychores.2012.11.007
   VANBERGEHENEGOUWEN GP, 1993, GUT, V34, P1473, DOI 10.1136/gut.34.11.1473
   Vanuytsel T, 2013, TISSUE BARRIERS, V1, DOI 10.4161/tisb.27321
   Vici G, 2016, CLIN NUTR, V35, P1236, DOI 10.1016/j.clnu.2016.05.002
   Villafuerte-Galvez J, 2015, ALIMENT PHARM THER, V42, P753, DOI 10.1111/apt.13319
   Vilppula A, 2011, BMC GASTROENTEROL, V11, DOI 10.1186/1471-230X-11-136
   VLISSIDES DN, 1986, BRIT J PSYCHIAT, V148, P447, DOI 10.1192/bjp.148.4.447
   Volkan B, 2018, TURK J GASTROENTEROL, V29, P215, DOI 10.5152/tjg.2018.17451
   Volta U, 2014, BMC MED, V12, DOI 10.1186/1741-7015-12-85
   Vriezinga SL, 2014, NEW ENGL J MED, V371, P1304, DOI 10.1056/NEJMoa1404172
   Walker-Smith J.A., 1996, PRACTICAL PEDIAT GAS
   WALKERSMITH JA, 1990, ARCH DIS CHILD, V65, P909, DOI 10.1136/adc.65.8.909
   Werkstetter KJ, 2017, GASTROENTEROLOGY, V153, P924, DOI 10.1053/j.gastro.2017.06.002
   Whitehead L, 2016, J MED INTERNET RES, V18, DOI 10.2196/jmir.4883
   Wierdsma NJ, 2013, NUTRIENTS, V5, P3975, DOI 10.3390/nu5103975
   Wieser H, 2007, FOOD MICROBIOL, V24, P115, DOI 10.1016/j.fm.2006.07.004
   Wild D, 2010, ALIMENT PHARM THER, V32, P573, DOI 10.1111/j.1365-2036.2010.04386.x
   Wong GWK, 2015, CHEM IMMUNOL ALLERGY, V101, P30, DOI 10.1159/000371662
   Zanchi C, 2008, J PEDIATR-US, V153, P262, DOI 10.1016/j.jpeds.2008.03.003
   Zanini B, 2015, ALIMENT PHARM THER, V42, P968, DOI 10.1111/apt.13372
   Zhao ZY, 2016, J IMMUNOL METHODS, V430, P28, DOI 10.1016/j.jim.2016.01.011
   Zis P, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101445
   Zylberberg HM, 2017, EUR J GASTROEN HEPAT, V29, P1091, DOI 10.1097/MEG.0000000000000932
NR 203
TC 0
Z9 0
U1 1
U2 39
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 8755-9129
EI 1525-6103
J9 FOOD REV INT
JI Food Rev. Int.
PY 2023
VL 39
IS 7
BP 4388
EP 4418
DI 10.1080/87559129.2021.2024566
EA JAN 2022
PG 31
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA U5IO8
UT WOS:000750905600001
DA 2025-06-11
ER

PT J
AU Sato, K
   Kawamura, T
   Yamagiwa, S
AF Sato, Kazunari
   Kawamura, Toshihiko
   Yamagiwa, Satoshi
TI The "Senobi" breathing exercise ameliorates depression in obese women
   through up-regulation of sympathetic nerve activity and hormone
   secretion
SO BIOMEDICAL RESEARCH-TOKYO
LA English
DT Article
ID GROWTH-HORMONE; VISCERAL FAT; METABOLIC SYNDROME; ADULTS; HYPOTHESIS;
   DISEASE; LEPTIN; TISSUE; MOOD; MASS
AB Obese individuals have an increased risk of developing depression. This study aimed to determine whether the "Senobi" breathing exercise (SBE), a stretching-breathing exercise that we have established, could relieve depression, especially in obese women. Forty premenopausal women, aged 40 to 49 years, participated in the present study. Twenty were healthy, and the other 20 were obese (body mass index > 25 and body fat > 30%) and in a depressive state (OWD). Sympathetic nerve activity determined by analyzing heart rate variability, and the hormone levels in the urine were investigated before and 30 min after one minute of SBE. The relative proportion of sympathetic nerve activity among healthy women in the daytime was 79.2 +/- 2.3%, whereas that in OWD group was 30.4 +/- 1.9%. After one minute of SBE, significant up-regulation of sympathetic nerve activity and increased concentrations of catecholamines, estradiol, and growth hormone (all P values < 0.001) were observed in OWD group. After 30 days of SBE, the sympathetic nerve activity and hormone levels had recovered in OWD group, and the depressive state, as evaluated by the Hamilton Depression Scale, had ameliorated. The "Senobi" breathing exercise was found to be effective for amelioration of depression in obese women possibly through up-regulation of sympathetic nerve activity and hormone secretion.
C1 [Sato, Kazunari] Aoyama Clin, Div Internal Med, Nishi Ku, Niigata 9502002, Japan.
   [Sato, Kazunari] Meirin Coll, Div Internal Med, Niigata, Japan.
   [Kawamura, Toshihiko] Niigata Univ, Sch Med, Dept Immunol, Niigata, Japan.
   [Yamagiwa, Satoshi] Niigata Univ, Div Gastroenterol & Hepatol, Grad Sch Med & Dent Sci, Niigata, Japan.
C3 Niigata University; Niigata University
RP Sato, K (corresponding author), Aoyama Clin, Div Internal Med, Nishi Ku, 1-2-21 Aoyama, Niigata 9502002, Japan.
EM mansankkk@yahoo.co.jp
FU Japan Society for the Promotion of Science (JSPS)
FX This work was supported in part with a grant from Japan Society for the
   Promotion of Science (JSPS). We thank 40 women participated in this
   study who permitted to publish this information about their cases.
CR Abe S, 2009, J PAEDIATR CHILD H, V45, P636, DOI 10.1111/j.1440-1754.2009.01586.x
   Andrade L, 2003, INT J METH PSYCH RES, V12, P3, DOI 10.1002/mpr.138
   BRAY GA, 1990, INT J OBESITY, V14, P77
   Bray GA, 1998, RECENT PROG HORM RES, V53, P95
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   Farmer A, 2008, BRIT J PSYCHIAT, V192, P351, DOI 10.1192/bjp.bp.107.038380
   Franco C, 2007, J CLIN ENDOCR METAB, V92, P2644, DOI 10.1210/jc.2007-0068
   Franco C, 2009, GROWTH HORM IGF RES, V19, P112, DOI 10.1016/j.ghir.2008.07.001
   Fumoto M, 2010, BEHAV BRAIN RES, V213, P1, DOI 10.1016/j.bbr.2010.04.017
   HALAAS JL, 1995, SCIENCE, V269, P543, DOI 10.1126/science.7624777
   Heine PA, 2000, P NATL ACAD SCI USA, V97, P12729, DOI 10.1073/pnas.97.23.12729
   Irving BA, 2009, J CLIN ENDOCR METAB, V94, P1979, DOI 10.1210/jc.2008-2256
   Janssen I, 2002, DIABETES CARE, V25, P431, DOI 10.2337/diacare.25.3.431
   Johannsson G., 1999, Journal of Endocrinological Investigation, V22, P41
   LUPPINO FS, ARCH GEN PSYCHIAT, V67, P220
   Mark AL, 2009, HYPERTENSION, V53, P375, DOI 10.1161/HYPERTENSIONAHA.108.124255
   Masheb RM, 2008, J CONSULT CLIN PSYCH, V76, P900, DOI 10.1037/a0012917
   Mekala KC, 2009, J CLIN ENDOCR METAB, V94, P130, DOI 10.1210/jc.2008-1357
   Meyer RH, 2007, APPL ERGON, V38, P549, DOI 10.1016/j.apergo.2006.08.005
   Murray CJL, 1997, LANCET, V349, P1498, DOI 10.1016/S0140-6736(96)07492-2
   Nilsson M, 2007, BMC MED GENET, V8, DOI 10.1186/1471-2350-8-73
   O'Leary VB, 2006, J APPL PHYSIOL, V100, P1584, DOI 10.1152/japplphysiol.01336.2005
   Ritz T, 2006, PSYCHOSOM MED, V68, P617, DOI 10.1097/01.psy.0000228010.96408.ed
   Roiser JP, 2008, NEUROPSYCHOPHARMACOL, V33, P1992, DOI 10.1038/sj.npp.1301581
   Sato K, 2010, J INVEST MED, V58, P968, DOI 10.231/JIM.0b013e3181f9167b
   Sato K, 2010, BIOMED RES-TOKYO, V31, P259, DOI 10.2220/biomedres.31.259
   Schmidt PJ, 2009, ANN NY ACAD SCI, V1179, P70, DOI 10.1111/j.1749-6632.2009.04982.x
   Shapiro D, 2007, EVID-BASED COMPL ALT, V4, P493, DOI 10.1093/ecam/nel114
   Strecker K, 2008, EXPERT OPIN EMERG DR, V13, P573, DOI 10.1517/14728210802596906 
   Vahl N, 1997, AM J PHYSIOL-ENDOC M, V272, pE1108, DOI 10.1152/ajpendo.1997.272.6.E1108
   Yuen KCJ, 2007, DIABETES OBES METAB, V9, P11, DOI 10.1111/j.1463-1326.2006.00591.x
NR 31
TC 2
Z9 3
U1 0
U2 4
PU BIOMEDICAL RESEARCH PRESS LTD
PI SAPPORO
PA HOKKAIDO UNIV, LAB HISTOLOGY & CYTOLOGY, C/O TOSHIHIKO IWANAGA, KITA
   15-NISHI 7, SAPPORO, 060-8638, JAPAN
SN 0388-6107
J9 BIOMED RES-TOKYO
JI Biomed. Res.
PD APR
PY 2011
VL 32
IS 2
BP 175
EP 180
DI 10.2220/biomedres.32.175
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 755TA
UT WOS:000289958400012
PM 21551954
OA Bronze
DA 2025-06-11
ER

PT J
AU Bourebaba, L
   Michalak, I
   Baouche, M
   Kucharczyk, K
   Marycz, K
AF Bourebaba, Lynda
   Michalak, Izabela
   Baouche, Meriem
   Kucharczyk, Katarzyna
   Marycz, Krzysztof
TI Cladophora glomerata methanolic extract promotes chondrogenic
   gene expression and cartilage phenotype differentiation in equine
   adipose-derived mesenchymal stromal stem cells affected by metabolic
   syndrome
SO STEM CELL RESEARCH & THERAPY
LA English
DT Article
DE Cladophora glomerata; EMS; ASCs; Chondrogenesis; Hypertrophy; microRNA
ID CHONDROCYTE DIFFERENTIATION; OXIDATIVE STRESS; AGGRECAN GENE;
   DYSFUNCTION; APOPTOSIS; AUTOPHAGY; EMPHASIS; PATHWAY; BINDING; SOX9
AB Background: Chondrogenesis represents a highly dynamic cellular process that leads to the establishment of various types of cartilage. However, when stress-related injuries occur, a rapid and efficient regeneration of the tissues is necessary to maintain cartilage integrity. Mesenchymal stem cells (MSCs) are known to exhibit high capacity for self-renewal and pluripotency effects, and thus play a pivotal role in the repair and regeneration of damaged cartilage. On the other hand, the influence of certain pathological conditions such as metabolic disorders on MSCs can seriously impair their regenerative properties and thus reduce their therapeutic potential.
   Objectives: In this investigation, we attempted to improve and potentiate the in vitro chondrogenic ability of adipose-derived mesenchymal stromal stem cells (ASCs) isolated from horses suffering from metabolic syndrome.
   Methods: Cultured cells in chondrogenic-inductive medium supplemented with Cladophora glomerata methanolic extract were experimented for expression of the main genes and microRNAs involved in the differentiation process using RT-PCR, for their morphological changes through confocal and scanning electron microscopy and for their physiological homeostasis.
   Results: The different added concentrations of C. glomerata extract to the basic chondrogenic inductive culture medium promoted the proliferation of equine metabolic syndrome ASCs (ASCs(EMS)) and resulted in chondrogenic phenotype differentiation and higher mRNA expression of collagen type II, aggrecan, cartilage oligomeric matrix protein, and Sox9 among others. The results reveal an obvious inhibitory effect of hypertrophy and a strong repression of miR-145-5p, miR-146-3p, and miR-34a and miR-449a largely involved in cartilage degradation. Treated cells additionally exhibited significant reduced apoptosis and oxidative stress, as well as promoted viability and mitochondrial potentiation.
   Conclusion: Chondrogenesis in EqASCs(EMS) was found to be prominent after chondrogenic induction in conditions containing C. glomerata extract, suggesting that the macroalgae could be considered for the enhancement of ASC cultures and their reparative properties.
C1 [Bourebaba, Lynda; Baouche, Meriem; Kucharczyk, Katarzyna; Marycz, Krzysztof] Wroclaw Univ Environm & Life Sci, Dept Expt Biol, Fac Biol & Anim Sci, Norwida 27B, PL-50375 Wroclaw, Poland.
   [Bourebaba, Lynda; Baouche, Meriem; Marycz, Krzysztof] Int Inst Translat Med, Jesionowa 11, PL-55114 Wisznia Mala, Malin, Poland.
   [Michalak, Izabela] Wroclaw Univ Sci & Technol, Fac Chem, Dept Adv Mat Technol, Smoluchowskiego 25, PL-50372 Wroclaw, Poland.
   [Marycz, Krzysztof] Cardinal Stefan Wyszynski Univ UKSW, Inst Med Sci, Coll Med, Woycickiego 1-3, PL-01938 Warsaw, Poland.
C3 Wroclaw University of Environmental & Life Sciences; Wroclaw University
   of Science & Technology; Cardinal Stefan Wyszynski University in Warsaw
RP Marycz, K (corresponding author), Wroclaw Univ Environm & Life Sci, Dept Expt Biol, Fac Biol & Anim Sci, Norwida 27B, PL-50375 Wroclaw, Poland.; Marycz, K (corresponding author), Int Inst Translat Med, Jesionowa 11, PL-55114 Wisznia Mala, Malin, Poland.
EM krzysztof.marycz@upwr.edu.pl
RI Bourebaba, Lynda/AAX-7613-2020; Baouche, Meriem/GQP-6178-2022; Michalak,
   Izabela/P-3770-2015
OI Baouche, Meriem/0000-0002-7344-1769; Michalak,
   Izabela/0000-0001-8084-9642; Lynda, Bourebaba/0000-0003-0660-8706
FU National Science Centre in Poland [2015/18/E/NZ9/00607]
FX This work was financed in the framework of grant entitled "The effect of
   bioactive algae enriched by biosorption in the certain minerals such as
   Cr(III), Mg(II) and Mn(II) on the status of glucose in the course of
   metabolic syndrome horses. Evaluation in vitro and in vivo" (No
   2015/18/E/NZ9/00607) attributed by The National Science Centre in
   Poland.
CR Ahmed S, 2010, ARTHRITIS RES THER, V12, DOI 10.1186/ar2982
   Akiyama H, 2002, GENE DEV, V16, P2813, DOI 10.1101/gad.1017802
   Baldari S, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18102087
   Blanco FJ, 1998, ARTHRITIS RHEUM, V41, P284, DOI 10.1002/1529-0131(199802)41:2<284::AID-ART12>3.3.CO;2-K
   Blanco FJ, 2004, MITOCHONDRION, V4, P715, DOI 10.1016/j.mito.2004.07.022
   Bourebaba L, 2019, BIOMED PHARMACOTHER, V111, P6, DOI 10.1016/j.biopha.2018.12.020
   Chen D, 2017, BONE RES, V5, DOI 10.1038/boneres.2016.44
   Cokelaere S, 2016, VET J, V214, P61, DOI 10.1016/j.tvjl.2016.02.005
   Cooper KL, 2013, NATURE, V495, P375, DOI 10.1038/nature11940
   DESJARDINS MR, 1990, CAN VET J, V31, P565
   Dimmeler S, 2008, CIRC RES, V102, P1319, DOI 10.1161/CIRCRESAHA.108.175943
   Farvin KHS, 2013, FOOD CHEM, V138, P1670, DOI 10.1016/j.foodchem.2012.10.078
   Gerber HP, 1999, NAT MED, V5, P623, DOI 10.1038/9467
   Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
   Gris D., 2013, Public Access NIH Public Access, V185, P974, DOI [10.1038/mp.2011.182, DOI 10.1038/MP.2011.182]
   Han Y, 2008, MOL CELL BIOL, V28, P4999, DOI 10.1128/MCB.00695-08
   Hudson JB, 1998, J APPL PHYCOL, V10, P427, DOI 10.1023/A:1008004117305
   Jin L, 2014, INT J MOL MED, V34, P451, DOI 10.3892/ijmm.2014.1808
   Kalamegam G, 2018, ADV EXP MED BIOL, V1089, P23, DOI 10.1007/5584_2018_205
   Khalifé S, 2011, ARTHRITIS RES THER, V13, DOI 10.1186/ar3222
   Khanna D, 2007, CURR OPIN PHARMACOL, V7, P344, DOI 10.1016/j.coph.2007.03.002
   Kornicka K, 2018, STEM CELL REV REP, V14, P337, DOI 10.1007/s12015-018-9809-x
   Lee PT, 2017, J CELL BIOCHEM, V118, P172, DOI 10.1002/jcb.25623
   Lo Monaco M, 2018, STEM CELLS INT, V2018, DOI 10.1155/2018/9079538
   Lu HD, 2016, INT J CLIN EXP PATHO, V9, P11388
   Maldonado M, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/284873
   Marycz K, 2018, STEM CELLS INT, V2018, DOI 10.1155/2018/5340756
   Marycz K, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19010165
   Marycz K, 2017, MAR DRUGS, V15, DOI 10.3390/md15120385
   Marycz K, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/4710326
   Marycz K, 2016, J CELL MOL MED, V20, P2384, DOI 10.1111/jcmm.12932
   Miyaki S, 2012, NAT REV RHEUMATOL, V8, P543, DOI 10.1038/nrrheum.2012.128
   Moffa AB, 2007, J CELL PHYSIOL, V210, P720, DOI 10.1002/jcp.20880
   Monteiro R, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/289645
   Nawrocka D, 2017, MAR DRUGS, V15, DOI 10.3390/md15080237
   Oh CD, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0107577
   Paik S, 2012, STEM CELLS DEV, V21, P3298, DOI 10.1089/scd.2011.0732
   Papaioannou G, 2015, J BONE MINER RES, V30, P1044, DOI 10.1002/jbmr.2438
   Pearle AD, 2005, CLIN SPORT MED, V24, P1, DOI 10.1016/j.csm.2004.08.007
   Regan E, 2005, ARTHRITIS RHEUM, V52, P3479, DOI 10.1002/art.21387
   Ruiz-Romero C, 2009, MOL CELL PROTEOMICS, V8, P172, DOI 10.1074/mcp.M800292-MCP200
   Selvamurugan N, 2006, J CELL BIOCHEM, V99, P545, DOI 10.1002/jcb.20878
   Srimaroeng C, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/320167
   Stanton H, 2011, BBA-MOL BASIS DIS, V1812, P1616, DOI 10.1016/j.bbadis.2011.08.009
   Strong AL, 2015, STEM CELLS INT, V2015, DOI 10.1155/2015/412467
   Suszynska M, 2014, J OVARIAN RES, V7, DOI 10.1186/1757-2215-7-66
   Thirunavukkarasu K, 2006, BIOCHEM BIOPH RES CO, V345, P197, DOI 10.1016/j.bbrc.2006.04.023
   Tsai YW, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024001
   Udalamaththa VL, 2016, STEM CELL RES THER, V7, DOI 10.1186/s13287-016-0366-4
   Wang CY, 2010, APOPTOSIS, V15, P439, DOI 10.1007/s10495-009-0431-x
   Wang L, 2013, ANAL CELL PATHOL, V36, P93, DOI [10.3233/ACP-130084, 10.1155/2013/790698]
   Wang Meina, 2013, CARTILAGE DEGENERATI, P61, DOI [10.1111/j.1749-6632.2011.06258.x, DOI 10.1111/J.1749-6632.2011.06258.X]
   Xu JY, 2018, BIOSCIENCE REP, V38, DOI 10.1042/BSR20171109
   Zhong LL, 2015, INT J MOL SCI, V16, P19225, DOI 10.3390/ijms160819225
   Zhuo Q, 2012, NAT REV RHEUMATOL, V8, P729, DOI 10.1038/nrrheum.2012.135
   Zwickl H, 2016, CARTILAGE, V7, P185, DOI 10.1177/1947603515615388
NR 56
TC 9
Z9 10
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1757-6512
J9 STEM CELL RES THER
JI Stem Cell Res. Ther.
PD DEC 17
PY 2019
VL 10
IS 1
AR 392
DI 10.1186/s13287-019-1499-z
PG 20
WC Cell & Tissue Engineering; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA KC6OO
UT WOS:000507294800001
PM 31847882
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Moilanen, P
   Liukkonen, T
   Jokelainen, J
   Keinänen-Kiukaanniemi, S
   Puukka, K
   Timonen, M
   Auvinen, J
   Eskola, P
AF Moilanen, Pauli
   Liukkonen, Timo
   Jokelainen, Jari
   Keinanen-Kiukaanniemi, Sirkka
   Puukka, Katri
   Timonen, Markku
   Auvinen, Juha
   Eskola, Pasi
TI Cross-sectional analysis of depressive symptom profiles and serum
   C-reactive protein levels: data from the Northern Finland 1966 birth
   cohort
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Depression; CRP; atypical; non-atypical; BDI-II; birth cohort
ID INFLAMMATORY MARKERS; OLDER-ADULTS; METABOLIC SYNDROME; NATIONAL-HEALTH;
   ASSOCIATION; METAANALYSIS; INTERLEUKIN-6; IL-6; DISORDER; RISK
AB PurposeIndividuals with depression exhibit significantly higher levels of systemic inflammation than those without depression, particularly among those with atypical depression. However, this association has been less convincing at the population level among individuals without a formal depression diagnosis but with suggestive symptoms. Our aim was to clarify this association.Materials and methodsIn a large birth cohort sample of the Finnish general population, we examined the cross-sectional association between high-sensitivity C-reactive protein (hsCRP) levels in venous blood samples and atypical/non-atypical depressive symptoms using the Beck Depression Inventory-II to screen 5443 middle-aged participants.ResultsAs expected, depressive symptoms associated to elevated hsCRP-levels compared to non-depressed. Participants with the atypical subtype of depressive symptoms (n = 84) had an odds ratio (OR) of 2.59 (95% CI 1.40-4.81) for elevated hsCRP levels compared to the non-depressed group. Similarly, our findings indicate that participants with non-atypical symptoms (n = 440) also showed an OR of 1.42 (95% CI 1.05-1.92) when compared to the non-depressed group (n = 4919).ConclusionsThese results provide additional support for previous research linking depression and inflammation and add to the field with a unique and sizeable study population. Furthermore, the current results support the notion that different types of depressive symptoms may be associated with inflammatory markers in slightly different ways.
C1 [Moilanen, Pauli; Liukkonen, Timo; Jokelainen, Jari; Keinanen-Kiukaanniemi, Sirkka; Timonen, Markku; Auvinen, Juha; Eskola, Pasi] Univ Oulu, Res Unit Populat Hlth, Oulu, Finland.
   [Liukkonen, Timo] Savonlinna Cent Hosp, Dept Psychiat, Savonlinna, Finland.
   [Jokelainen, Jari; Keinanen-Kiukaanniemi, Sirkka; Timonen, Markku] Oulu Univ Hosp, Unit Primary Care, Oulu, Finland.
   [Keinanen-Kiukaanniemi, Sirkka; Timonen, Markku; Auvinen, Juha; Eskola, Pasi] Wellbeing Serv Cty North Ostrobothn Pohde, Oulu, Finland.
   [Puukka, Katri] Oulu Univ Hosp, Med Res Ctr Oulu, NordLab Oulu, Oulu, Finland.
   [Puukka, Katri] Univ Oulu, Dept Clin Chem, Oulu, Finland.
   [Auvinen, Juha] Oulu Univ Hosp, Med Res Ctr Oulu, Oulu, Finland.
   [Auvinen, Juha] Univ Oulu, Oulu, Finland.
   [Eskola, Pasi] Univ Oulu, Fac Med, Res Unit Populat Hlth Poph, POB 8000, Oulu 90014, Finland.
C3 University of Oulu; University of Oulu; University of Oulu; University
   of Oulu; University of Oulu; University of Oulu; University of Oulu
RP Eskola, P (corresponding author), Univ Oulu, Fac Med, Res Unit Populat Hlth Poph, POB 8000, Oulu 90014, Finland.
EM pasi.eskola@oulu.fi
FU We express our sincerest gratitude to the field study team and study
   nurses who carried out all of the examinations and data collection. We
   would also like to thank Professor Paula Rantakallio, who launched the
   NFBC1966.
FX We express our sincerest gratitude to the field study team and study
   nurses who carried out all of the examinations and data collection. We
   would also like to thank Professor Paula Rantakallio, who launched the
   NFBC1966.
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   American Psychiatric Association (APA), 2013, Diagnostic and Statistical Manual of Mental Disorders, V5th ed
   Au B, 2015, INT J GERIATR PSYCH, V30, P976, DOI 10.1002/gps.4250
   Ballesio A, 2023, BRAIN BEHAV IMMUN-HL, V31, DOI 10.1016/j.bbih.2023.100647
   Beck AT, 1996, J PERS ASSESS, V67, P588, DOI 10.1207/s15327752jpa6703_13
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   Benazzi F, 2002, EUR ARCH PSY CLIN N, V252, P288, DOI 10.1007/s00406-002-0395-0
   Chocano-Bedoya PO, 2014, J AFFECT DISORDERS, V163, P25, DOI 10.1016/j.jad.2014.03.023
   Cosgrove KT, 2020, BRAIN BEHAV IMMUN, V83, P163, DOI 10.1016/j.bbi.2019.10.006
   Domènech-Abella J, 2018, J AFFECT DISORDERS, V241, P311, DOI 10.1016/j.jad.2018.08.077
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Dreon DM, 2003, LIFE SCI, V73, P1245, DOI 10.1016/S0024-3205(03)00425-9
   Gallus S, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-29867-9
   Glaus J, 2018, PSYCHOL MED, V48, P961, DOI 10.1017/S0033291717002744
   Goodwin RD, 2003, PREV MED, V36, P698, DOI 10.1016/S0091-7435(03)00042-2
   Hickman RJ, 2014, J BEHAV MED, V37, P621, DOI 10.1007/s10865-013-9510-0
   Hiles SA, 2012, PSYCHOL MED, V42, P2015, DOI 10.1017/S0033291712000128
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Huang M, 2019, BRAIN BEHAV IMMUN, V75, P200, DOI 10.1016/j.bbi.2018.10.007
   Joffe H, 1998, BIOL PSYCHIAT, V44, P798, DOI 10.1016/S0006-3223(98)00169-3
   Jokela M, 2016, JAMA PSYCHIAT, V73, P87, DOI 10.1001/jamapsychiatry.2015.1977
   Kappelmann N, 2021, BRAIN BEHAV IMMUN, V95, P256, DOI 10.1016/j.bbi.2021.03.024
   Karlovic D, 2012, PSYCHIAT RES, V198, P74, DOI 10.1016/j.psychres.2011.12.007
   Khandaker GM, 2014, JAMA PSYCHIAT, V71, P1121, DOI 10.1001/jamapsychiatry.2014.1332
   Krenek P, 2023, PSYCHOPATHOLOGY, V56, P403, DOI 10.1159/000528907
   Lamers F, 2018, PSYCHOL MED, V48, P1102, DOI 10.1017/S0033291717002483
   Lamers F, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.115
   Lamers F, 2013, MOL PSYCHIATR, V18, P692, DOI 10.1038/mp.2012.144
   Lamers F, 2019, BIOL PSYCHIAT, V85, P829, DOI 10.1016/j.biopsych.2018.12.020
   Lee DH, 2019, INT J CANCER, V145, P360, DOI 10.1002/ijc.32111
   Levitan RD, 1997, AM J PSYCHIAT, V154, P934
   Liukkonen T, 2007, PSYCHOSOM MED, V69, P756, DOI 10.1097/PSY.0b013e318157cb96
   Liukkonen T, 2006, BIOL PSYCHIAT, V60, P825, DOI 10.1016/j.biopsych.2006.02.016
   Luger TM, 2014, ADDICT BEHAV, V39, P1418, DOI 10.1016/j.addbeh.2014.05.011
   Muscatell KA, 2020, MOL PSYCHIATR, V25, P2189, DOI 10.1038/s41380-018-0259-2
   Nordstrom Tanja, 2022, Int J Epidemiol, V50, P1786, DOI 10.1093/ije/dyab109
   Osimo EF, 2020, BRAIN BEHAV IMMUN, V87, P901, DOI 10.1016/j.bbi.2020.02.010
   Osimo EF, 2020, COMPR PSYCHIAT, V96, DOI 10.1016/j.comppsych.2019.152143
   Osimo EF, 2019, PSYCHOL MED, V49, P1958, DOI 10.1017/S0033291719001454
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pearson TA, 2003, CIRCULATION, V107, P499, DOI 10.1161/01.CIR.0000052939.59093.45
   Penninx BWJH, 2021, AM J PSYCHIAT, V178, P480, DOI 10.1176/appi.ajp.2021.21040332
   Pitharouli MC, 2021, AM J PSYCHIAT, V178, P522, DOI 10.1176/appi.ajp.2020.20060947
   ROY A, 1991, ARCH GEN PSYCHIAT, V48, P428
   Rudaz DA, 2017, J AFFECT DISORDERS, V222, P195, DOI 10.1016/j.jad.2017.07.016
   Rudolf S, 2014, PSYCHIAT RES, V217, P34, DOI 10.1016/j.psychres.2014.02.016
   Simmons WK, 2020, MOL PSYCHIATR, V25, P1457, DOI 10.1038/s41380-018-0093-6
   Skovlund C, 2016, JAMA PSYCHIAT, V73, P1154, DOI 10.1001/jamapsychiatry.2016.2387
   Smith KJ, 2018, EXP GERONTOL, V102, P109, DOI 10.1016/j.exger.2017.12.005
   Sullivan PF, 1998, AM J PSYCHIAT, V155, P1398, DOI 10.1176/ajp.155.10.1398
   Sundell L, 2008, STROKE, V39, P3179, DOI 10.1161/STROKEAHA.108.520817
   Valkanova V, 2013, J AFFECT DISORDERS, V150, P736, DOI 10.1016/j.jad.2013.06.004
   Voils SA, 2014, DIABETES METAB SYND, V8, P88, DOI 10.1016/j.dsx.2014.04.021
   Volpato S, 2004, CIRCULATION, V109, P607, DOI 10.1161/01.CIR.0000109503.13955.00
   Wium-Andersen MK, 2016, BRIT J PSYCHIAT, V208, P138, DOI 10.1192/bjp.bp.114.150870
   Wium-Andersen MK, 2014, BIOL PSYCHIAT, V76, P249, DOI 10.1016/j.biopsych.2013.10.009
   Wium-Andersen MK, 2013, JAMA PSYCHIAT, V70, P176, DOI 10.1001/2013.jamapsychiatry.102
   Zalli A, 2016, PSYCHOPHARMACOLOGY, V233, P1669, DOI 10.1007/s00213-015-3919-9
NR 58
TC 1
Z9 2
U1 0
U2 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0803-9488
EI 1502-4725
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PD FEB 1
PY 2024
VL 78
IS 2
BP 95
EP 102
DI 10.1080/08039488.2023.2274341
EA OCT 2023
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GH1O7
UT WOS:001090951000001
PM 37905346
DA 2025-06-11
ER

PT J
AU Lin, YH
   Chang, HT
   Wang, YF
   Fuh, JL
   Wang, SJ
   Chen, HS
   Li, SR
   Lin, MH
   Chen, TJ
   Hwang, SJ
AF Lin, Yi-Hsuan
   Chang, Hsiao-Ting
   Wang, Yen-Feng
   Fuh, Jong-Ling
   Wang, Shuu-Jiun
   Chen, Harn-Shen
   Li, Sih-Rong
   Lin, Ming-Hwai
   Chen, Tzeng-Ji
   Hwang, Shinn-Jang
TI The association of the comorbidity status of metabolic syndrome and
   cognitive dysfunction with health-related quality of life
SO QUALITY OF LIFE RESEARCH
LA English
DT Article
DE Metabolic syndrome; Cognitive dysfunction; Health-related quality of
   life; SF-36 Health Survey; Taiwan
ID DISEASE; IMPACT; RISK; IMPAIRMENT; INDIVIDUALS; DEPRESSION; MANAGEMENT
AB Purpose Both metabolic syndrome (MetS) and cognitive dysfunction impair health-related quality of life (HRQOL). This study aims to determine whether individuals experiencing both MetS and cognitive dysfunction have lower HRQOL. Methods This cross-sectional study enrolled 567 participants who attended outpatient clinics at a medical center in northern Taiwan. MetS was diagnosed according to the modified criteria for the Asian population. Cognitive function was categorized as normal, mild cognitive dysfunction, and advanced cognitive dysfunction according to the score of the Montreal Cognitive Assessment, Taiwanese version. HRQOL was assessed using the SF-36v2 (R) Health Survey (SF-36v2). The associations of the comorbidity status of MetS and cognitive dysfunction with HRQOL were analyzed using linear regression models, adjusting for age, sex, marital status, education level, income groups, and activities of daily living. Results Out of 567 participants, 33 (5.8%) had MetS with mild cognitive dysfunction, and 34 (6.0%) had MetS with advanced cognitive dysfunction. Participants with both MetS and advanced cognitive dysfunction exhibited the lowest scores in the physical component summary and almost all scales of HRQOL. MetS exacerbated the inverse association between mild cognitive dysfunction and the mental component summary. For those with MetS, the scores on scales of role physical, bodily pain, vitality, and social functioning worsened as cognitive function deteriorated (all Ptrend<0.05). Conclusion As the severity of comorbidity between MetS and cognitive dysfunction varies, patients exhibited poorer performance in different aspects of HRQOL. Future research is needed to find solutions to improve HRQOL for patients with both MetS and cognitive dysfunction.
C1 [Lin, Yi-Hsuan] Taipei Vet Gen Hosp, Dept Med Educ, Taipei, Taiwan.
   [Lin, Yi-Hsuan; Chang, Hsiao-Ting; Wang, Yen-Feng; Fuh, Jong-Ling; Wang, Shuu-Jiun; Chen, Harn-Shen; Lin, Ming-Hwai; Chen, Tzeng-Ji; Hwang, Shinn-Jang] Natl Yang Ming Chiao Tung Univ, Coll Med, Sch Med, Taipei, Taiwan.
   [Lin, Yi-Hsuan; Chang, Hsiao-Ting; Li, Sih-Rong; Lin, Ming-Hwai; Chen, Tzeng-Ji; Hwang, Shinn-Jang] Taipei Vet Gen Hosp, Dept Family Med, 201 Sec 2,Shipai Rd, Taipei 11217, Taiwan.
   [Wang, Yen-Feng; Fuh, Jong-Ling; Wang, Shuu-Jiun] Taipei Vet Gen Hosp, Neurol Inst, Dept Neurol, Taipei, Taiwan.
   [Chen, Harn-Shen] Taipei Vet Gen Hosp, Dept Med, Div Endocrinol & Metab, Taipei, Taiwan.
   [Chen, Tzeng-Ji] Taipei Vet Gen Hosp, Dept Family Med, Hsinchu Branch, Hsinchu Cty, Taiwan.
   [Chen, Tzeng-Ji] Natl Chung Hsing Univ, Dept Postbaccalaureate Med, Taichung, Taiwan.
   [Hwang, Shinn-Jang] En Chu Kong Hosp, Dept Family Med, New Taipei City, Taiwan.
C3 Taipei Veterans General Hospital; National Yang Ming Chiao Tung
   University; Taipei Veterans General Hospital; Taipei Veterans General
   Hospital; Taipei Veterans General Hospital; Taipei Veterans General
   Hospital; National Chung Hsing University; En Chu Kong Hospital
RP Chang, HT (corresponding author), Natl Yang Ming Chiao Tung Univ, Coll Med, Sch Med, Taipei, Taiwan.; Chang, HT (corresponding author), Taipei Vet Gen Hosp, Dept Family Med, 201 Sec 2,Shipai Rd, Taipei 11217, Taiwan.
EM htchang.tw@gmail.com
RI Fuh, Jong-Ling/AFQ-4531-2022; Chen, TJ/AAH-8430-2021
FU Taipei Veterans General Hospital [V109E-005-4, V110E-005-4, V111E-006-4,
   V112E-004-4]
FX This work was supported by grants from Taipei Veterans General Hospital.
   [Grant number: V109E-005-4, V110E-005-4, V111E-006-4, V112E-004-4]
CR Bae S, 2017, J ALZHEIMERS DIS, V60, P913, DOI [10.3233/JAD-161230, 10.3233/jad-161230]
   Burks HB, 2021, DEMENT GERIATR COGN, V50, P103, DOI 10.1159/000515317
   Capucho AM, 2022, NUTRIENTS, V14, DOI 10.3390/nu14071425
   Carriere I, 2014, J GERONTOL A-BIOL, V69, P79, DOI 10.1093/gerona/glt101
   Carrión RE, 2011, AM J PSYCHIAT, V168, P806, DOI 10.1176/appi.ajp.2011.10081209
   Chang H. T., 2009, THESIS
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Chew NWS, 2023, CELL METAB, V35, P414, DOI 10.1016/j.cmet.2023.02.003
   Coderre TJ, 2023, FRONT PAIN RES, V4, DOI 10.3389/fpain.2023.1111559
   Elferink MWO, 2015, TRANSL NEUROSCI, V6, P139, DOI 10.1515/tnsci-2015-0013
   Pequeno NPF, 2020, HEALTH QUAL LIFE OUT, V18, DOI 10.1186/s12955-020-01347-7
   Gray M, 2021, EXP GERONTOL, V143, DOI 10.1016/j.exger.2020.111164
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Gunstad J, 2020, AM PSYCHOL, V75, P219, DOI 10.1037/amp0000585
   Huang CC, 2022, J PERS MED, V12, DOI 10.3390/jpm12030350
   Hwang LC, 2006, J FORMOS MED ASSOC, V105, P626, DOI 10.1016/S0929-6646(09)60161-3
   Jefferson AL, 2008, AM J GERIAT PSYCHIAT, V16, P375, DOI 10.1097/JGP.0b013e318162f197
   Jekel K, 2015, ALZHEIMERS RES THER, V7, DOI 10.1186/s13195-015-0099-0
   Jia XF, 2021, BMC PSYCHIATRY, V21, DOI 10.1186/s12888-021-03495-6
   Kim HB, 2023, J AFFECT DISORDERS, V323, P46, DOI 10.1016/j.jad.2022.11.049
   Kitamura K, 2016, DEMENT GER COGN D EX, V6, P341, DOI 10.1159/000447963
   Kotwal AA, 2016, J GEN INTERN MED, V31, P854, DOI 10.1007/s11606-016-3696-0
   Koutsonida M, 2022, FRONT PSYCHOL, V13, DOI 10.3389/fpsyg.2022.981379
   LAWTON MP, 1969, GERONTOLOGIST, V9, P179, DOI 10.1093/geront/9.3_Part_1.179
   Lin YH, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-99767-y
   Lu J.F., 2002, Taiwan Journal of Public Health, V22, P501
   Ma XG, 2013, BMJ OPEN, V3, DOI 10.1136/bmjopen-2012-002418
   MAHONEY F I, 1965, Md State Med J, V14, P61
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Patino CM, 2016, J BRAS PNEUMOL, V42, P240, DOI 10.1590/S1806-37562016000000225
   Maruish ME, 2011, User's manual for the SF-36v2 Health Survey, V3
   Ng TP, 2016, JAMA NEUROL, V73, P456, DOI 10.1001/jamaneurol.2015.4899
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pan CW, 2015, SCI REP-UK, V5, DOI 10.1038/srep17301
   Pellegrino LD, 2013, CURR PSYCHIAT REP, V15, DOI 10.1007/s11920-013-0384-1
   Qu B, 2009, J INT MED RES, V37, P1184, DOI 10.1177/147323000903700425
   Saboya PP, 2016, REV LAT-AM ENFERM, V24, DOI 10.1590/1518-8345.1573.2848
   Schiepers OJG, 2005, PROG NEURO-PSYCHOPH, V29, P201, DOI 10.1016/j.pnpbp.2004.11.003
   Shimokawa A, 2001, BRAIN COGNITION, V47, P423, DOI 10.1006/brcg.2001.1318
   Shin JA, 2013, J DIABETES INVEST, V4, P334, DOI 10.1111/jdi.12075
   Srikanth V, 2020, LANCET DIABETES ENDO, V8, P535, DOI 10.1016/S2213-8587(20)30118-2
   Stites SD, 2018, ALZ DIS ASSOC DIS, V32, P276, DOI 10.1097/WAD.0000000000000262
   Stringhini S, 2011, PLOS MED, V8, DOI 10.1371/journal.pmed.1000419
   Taylor WD, 2013, MOL PSYCHIATR, V18, P963, DOI 10.1038/mp.2013.20
   Tsai CF, 2012, INT PSYCHOGERIATR, V24, P651, DOI 10.1017/S1041610211002298
   Tziallas D, 2012, EUR J CARDIOVASC NUR, V11, P297, DOI 10.1016/j.ejcnurse.2011.02.004
   Wu MS, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-22
   Yaffe K, 2004, JAMA-J AM MED ASSOC, V292, P2237, DOI 10.1001/jama.292.18.2237
   Yates KF, 2012, ARTERIOSCL THROM VAS, V32, P2060, DOI 10.1161/ATVBAHA.112.252759
   Zhang C, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0192333
NR 50
TC 0
Z9 0
U1 0
U2 2
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-9343
EI 1573-2649
J9 QUAL LIFE RES
JI Qual. Life Res.
PD DEC
PY 2024
VL 33
IS 12
BP 3421
EP 3433
DI 10.1007/s11136-024-03784-z
EA SEP 2024
PG 13
WC Health Care Sciences & Services; Health Policy & Services; Public,
   Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA N4J3J
UT WOS:001313285000005
PM 39269582
DA 2025-06-11
ER

PT J
AU Liu, H
   Lu, HY
AF Liu, Hong
   Lu, Hong-Yun
TI Nonalcoholic fatty liver disease and cardiovascular disease
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Nonalcoholic fatty liver disease; Cardiovascular disease; Metabolic
   syndrome; Risk assessment
ID INDEPENDENT RISK-FACTOR; BODY-MASS INDEX; ENDOTHELIAL FUNCTION; ARTERIAL
   STIFFNESS; METABOLIC SYNDROME; MORBID-OBESITY; VITAMIN-E; ASSOCIATION;
   ATHEROSCLEROSIS; STEATOHEPATITIS
AB Nonalcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD) are two diseases that are common in the general population. To date, many studies have been conducted and demonstrate a direct link between NAFLD and CVD, but the exact mechanisms for this complex relationship are not well established. A systematic search of the PubMed database revealed that several common mechanisms are involved in many of the local and systemic manifestations of NAFLD and lead to an increased cardiovascular risk. The possible mechanisms linking NAFLD and CVD include inflammation, oxidative stress, insulin resistance, ectopic adipose tissue distribution, dyslipidemia, endothelial dysfunction, and adiponectin, among others. The clinical implication is that patients with NAFLD are at an increased risk of CVD and should undergo periodic cardiovascular risk assessment. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
C1 [Liu, Hong; Lu, Hong-Yun] Sun Yat Sen Univ, Affiliated Hosp 5, Dept Endocrinol & Metab, Zhuhai 519000, Guangdong, Peoples R China.
C3 Sun Yat Sen University
RP Lu, HY (corresponding author), Sun Yat Sen Univ, Affiliated Hosp 5, Dept Endocrinol & Metab, Zhuhai 519000, Guangdong, Peoples R China.
EM luhongyun2013@163.com
RI LU, HONGYUN/AAG-1904-2020
CR Adams LA, 2004, AM J GASTROENTEROL, V99, P2365, DOI 10.1111/j.1572-0241.2004.40064.x
   Ahmed MH, 2012, J OBES, V2012, DOI 10.1155/2012/483135
   Ahmed MH, 2010, PRIM CARE DIABETES, V4, P129, DOI 10.1016/j.pcd.2010.02.004
   Akin L, 2013, ACTA PAEDIATR, V102, pe107, DOI 10.1111/apa.12099
   Alkhouri N, 2012, HEPATOLOGY, V55, P331, DOI [10.1002/hep.24767, 10.1002/hep.24721]
   Ampuero J, 2012, GASTROENT HEPAT-BARC, V35, P585, DOI 10.1016/j.gastrohep.2012.02.005
   Arslan U, 2012, J CARDIOL, V60, P210, DOI 10.1016/j.jjcc.2012.05.003
   Ashburn DD, 2010, CRIT CARE CLIN, V26, P625, DOI 10.1016/j.ccc.2010.06.006
   Baloseanu CL, 2012, ROM J MORPHOL EMBRYO, V53, P609
   Beaton MD, 2013, ALIMENT PHARM THER, V37, P720, DOI 10.1111/apt.12255
   Beaton MD, 2012, CAN J GASTROENTEROL, V26, P353, DOI 10.1155/2012/725468
   Bhatia LS, 2012, CURR OPIN CARDIOL, V27, P420, DOI 10.1097/HCO.0b013e328354829c
   Bhatia LS, 2012, EUR HEART J, V33, P1190, DOI 10.1093/eurheartj/ehr453
   Blackett PR, 2013, J CLIN LIPIDOL, V7, P65, DOI 10.1016/j.jacl.2012.04.079
   Bonapace S, 2012, DIABETES CARE, V35, P389, DOI 10.2337/dc11-1820
   Brandt ML, 2010, NAT REV ENDOCRINOL, V6, P637, DOI 10.1038/nrendo.2010.167
   Brown TM, 2012, CLIN GASTROENTEROL H, V10, P568, DOI 10.1016/j.cgh.2012.02.023
   Cakir E, 2012, MINERVA ENDOCRINOL, V37, P187
   Cameron I, 2012, CAN J PHYSIOL PHARM, V90, P1490, DOI [10.1139/Y2012-097, 10.1139/y2012-097]
   Catena C, 2013, NUTR METAB CARDIOVAS, V23, P389, DOI 10.1016/j.numecd.2012.05.007
   Chatrath H, 2012, SEMIN LIVER DIS, V32, P22, DOI 10.1055/s-0032-1306423
   Colak Y, 2013, ENDOCRINE, V43, P100, DOI 10.1007/s12020-012-9712-1
   Coracina A, 2012, NUTR METAB CARDIOVAS, V22, pE11, DOI 10.1016/j.numecd.2011.11.008
   DeFilippis AP, 2013, ATHEROSCLEROSIS, V227, P429, DOI 10.1016/j.atherosclerosis.2013.01.022
   Dixon JB, 2014, CLIN LIVER DIS, V18, P129, DOI 10.1016/j.cld.2013.09.011
   Dogru T, 2012, DIABETES RES CLIN PR, V96, P47, DOI 10.1016/j.diabres.2011.11.022
   Fan Jian-gao, 2010, Zhonghua Gan Zang Bing Za Zhi, V18, P676, DOI 10.3760/cma.j.issn.1007-3418.2010.09.008
   Feitosa MF, 2013, ATHEROSCLEROSIS, V227, P420, DOI 10.1016/j.atherosclerosis.2013.01.013
   Filippatos TD, 2008, DRUG SAFETY, V31, P53, DOI 10.2165/00002018-200831010-00005
   Gawrieh S, 2010, OBES SURG, V20, P1698, DOI 10.1007/s11695-010-0171-6
   Gökçe S, 2013, PEDIATR CARDIOL, V34, P308, DOI 10.1007/s00246-012-0447-9
   Hacihamdioglu B, 2011, TURKISH J PEDIATR, V53, P48
   Harrison AG, 2013, J AM SOC MASS SPECTR, V24, P1555, DOI 10.1007/s13361-013-0706-x
   Harrison SA, 2009, HEPATOLOGY, V49, P80, DOI 10.1002/hep.22575
   Hashizume H, 2013, ACTA MED OKAYAMA, V67, P45
   Hessheimer AJ, 2010, EUR J GASTROEN HEPAT, V22, P1239, DOI 10.1097/MEG.0b013e32833aa19b
   Heuer M, 2012, DIGESTION, V86, P107, DOI 10.1159/000339344
   Huang Y, 2012, ARTERIOSCL THROM VAS, V32, P2321, DOI 10.1161/ATVBAHA.112.252957
   Hurjui DM, 2012, MED-SURG J, V116, P692
   Hurjui DM, 2012, MED-SURG J, V116, P425
   Kim D, 2012, HEPATOLOGY, V56, P605, DOI 10.1002/hep.25593
   Koskinen J, 2012, ANN MED, V44, P187, DOI 10.3109/07853890.2010.532152
   Kubes P, 2012, GASTROENTEROLOGY, V143, P1158, DOI 10.1053/j.gastro.2012.09.008
   Kucukazman M, 2013, EUR J GASTROEN HEPAT, V25, P147, DOI 10.1097/MEG.0b013e32835a58b1
   Kwon YM, 2012, AM J GASTROENTEROL, V107, P1852, DOI 10.1038/ajg.2012.314
   Lavine JE, 2011, JAMA-J AM MED ASSOC, V305, P1659, DOI 10.1001/jama.2011.520
   Lee YJ, 2012, DIGEST DIS SCI, V57, P196, DOI 10.1007/s10620-011-1819-3
   Leite NC, 2011, LIVER INT, V31, P700, DOI 10.1111/j.1478-3231.2011.02482.x
   Leuschner UFH, 2010, HEPATOLOGY, V52, P472, DOI 10.1002/hep.23727
   Li GL, 2012, CLIN HEMORHEOL MICRO, V51, P59, DOI 10.3233/CH-2011-1509
   Li XM, 2012, ATHEROSCLEROSIS, V224, P480, DOI 10.1016/j.atherosclerosis.2012.07.002
   Lu HY, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/124958
   Mantovani A, 2012, J ENDOCRINOL INVEST, V35, P215, DOI 10.1007/BF03345421
   Motta AB, 2010, INT J CLIN PRACT, V64, P544, DOI 10.1111/j.1742-1241.2009.02259.x
   Nestel PJ, 2013, CURR OPIN LIPIDOL, V24, P1, DOI 10.1097/MOL.0b013e32835c0834
   Nseir W, 2012, DIGEST DIS SCI, V57, P1773, DOI 10.1007/s10620-012-2118-3
   de Carvalho SCR, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-37
   Ratziu V, 2011, J HEPATOL, V54, P1011, DOI 10.1016/j.jhep.2010.08.030
   Rivera R, 2010, ACTAS DERMO-SIFILOGR, V101, P657, DOI 10.1016/S1578-2190(10)70695-8
   Roitberg G E, 2010, Eksp Klin Gastroenterol, P20
   Saleh Dina Ahmed Amin, 2012, Pak J Biol Sci, V15, P68
   Samson SL, 2013, J DIABETES COMPLICAT, V27, P401, DOI 10.1016/j.jdiacomp.2012.12.005
   Santos RD, 2012, ATHEROSCLEROSIS, V224, P324, DOI 10.1016/j.atherosclerosis.2012.07.018
   Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929
   Satapathy SK, 2007, J GASTROEN HEPATOL, V22, P634, DOI 10.1111/j.1440-1746.2006.04756.x
   Senates E, 2012, MINERVA MED, V103, P369
   Severova MM, 2012, TERAPEVT ARKH, V84, P15
   Stepanova M, 2012, CLIN GASTROENTEROL H, V10, P646, DOI 10.1016/j.cgh.2011.12.039
   Swarbrick MM, 2008, BRIT J NUTR, V100, P947, DOI 10.1017/S0007114508968252
   Targher G, 2013, CLIN SCI, V125, P301, DOI 10.1042/CS20130036
   Thakur ML, 2012, ATHEROSCLEROSIS, V223, P507, DOI 10.1016/j.atherosclerosis.2012.06.005
   Treeprasertsuk S, 2012, LIVER INT, V32, P945, DOI 10.1111/j.1478-3231.2011.02753.x
   Tziomalos K, 2009, VASC HEALTH RISK MAN, V5, P441
   Vlachopoulos C, 2010, AM J HYPERTENS, V23, P1183, DOI 10.1038/ajh.2010.144
   Wang CC, 2012, KAOHSIUNG J MED SCI, V28, P151, DOI 10.1016/j.kjms.2011.10.005
   Williams KH, 2013, ENDOCR REV, V34, P84, DOI 10.1210/er.2012-1009
   Yang YY, 2012, LIVER TRANSPLANT, V18, P1371, DOI 10.1002/lt.23520
NR 77
TC 79
Z9 88
U1 0
U2 10
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD JUL 14
PY 2014
VL 20
IS 26
BP 8407
EP 8415
DI 10.3748/wjg.v20.i26.8407
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AL8LF
UT WOS:000339389500007
PM 25024598
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Wu, Y
   Ma, YC
AF Wu, Yue
   Ma, Yanchun
TI CCL2-CCR2 signaling axis in obesity and metabolic diseases
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Review
DE adipose tissue; CCL2; CCR2; inflammation; metabolic syndrome
ID MONOCYTE CHEMOATTRACTANT PROTEIN-1; ENDOPLASMIC-RETICULUM STRESS;
   LOW-DENSITY-LIPOPROTEIN; ADIPOSE-TISSUE HYPOXIA; MACROPHAGE CROSS-TALK;
   INSULIN-RESISTANCE; TRANSGENIC MICE; PHARMACOLOGICAL CHARACTERIZATION;
   REDUCES ATHEROSCLEROSIS; CARDIAC OVEREXPRESSION
AB Obesity and metabolic diseases, such as insulin resistance, type 2 diabetes, nonalcoholic fatty liver disease, and cardiovascular ailments, represent formidable global health challenges, bearing considerable implications for both morbidity and mortality rates. It has become increasingly evident that chronic, low-grade inflammation plays a pivotal role in the genesis and advancement of these conditions. The involvement of C-C chemokine ligand 2 (CCL2) and its corresponding receptor, C-C chemokine receptor 2 (CCR2), has been extensively documented in numerous inflammatory maladies. Recent evidence indicates that the CCL2/CCR2 pathway extends beyond immune cell recruitment and inflammation, exerting a notable influence on the genesis and progression of metabolic syndrome. The present review seeks to furnish a comprehensive exposition of the CCL2-CCR2 signaling axis within the context of obesity and metabolic disorders, elucidating its molecular mechanisms, functional roles, and therapeutic implications.
C1 [Wu, Yue; Ma, Yanchun] Shandong Normal Univ, Collaborat Innovat Ctr Cell Biol Univ Shandong, Shandong Prov Key Lab Anim Resistance Biol, Ctr Cell Struct & Funct,Coll Life Sci, Jinan, Peoples R China.
   [Wu, Yue] Shandong Normal Univ, Collaborat Innovat Ctr Cell Biol Univ Shandong, Shandong Prov Key Lab Anim Resistance Biol, Ctr Cell Struct & Funct,Coll Life Sci, Jinan 250014, Peoples R China.
C3 Shandong Normal University; Shandong Normal University
RP Wu, Y (corresponding author), Shandong Normal Univ, Collaborat Innovat Ctr Cell Biol Univ Shandong, Shandong Prov Key Lab Anim Resistance Biol, Ctr Cell Struct & Funct,Coll Life Sci, Jinan 250014, Peoples R China.
EM 620034@sdnu.edu.cn
FU National Natural Science Foundation of China; Natural Science Foundation
   of Shandong Province [ZR2021QC069];  [32100614]
FX This work was supported by the National Natural Science Foundation of
   China (32100614) and Natural Science Foundation of Shandong Province
   (ZR2021QC069).
CR Aiello RJ, 2010, ATHEROSCLEROSIS, V208, P370, DOI 10.1016/j.atherosclerosis.2009.08.017
   Ali MM, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9010134
   [Anonymous], 2020, LANCET, V396, P1129, DOI 10.1016/S0140-6736(20)32131-0
   BARNA BP, 1994, J NEUROIMMUNOL, V50, P101, DOI 10.1016/0165-5728(94)90220-8
   Bartoli C, 2001, ACTA NEUROPATHOL, V102, P385
   Bauer S, 2011, ENDOCRINOLOGY, V152, P26, DOI 10.1210/en.2010-1157
   Beltrán-Debón R, 2010, PHYTOMEDICINE, V17, P186, DOI 10.1016/j.phymed.2009.08.006
   Ble A, 2011, AM J NEPHROL, V34, P367, DOI 10.1159/000330685
   Boring L, 1998, NATURE, V394, P894, DOI 10.1038/29788
   Brodmerkel CM, 2005, J IMMUNOL, V175, P5370, DOI 10.4049/jimmunol.175.8.5370
   Cai DS, 2005, NAT MED, V11, P183, DOI 10.1038/nm1166
   Cai Shanshan, 2023, J Clin Invest, V133, DOI 10.1172/JCI159498
   Charo IF, 2006, NEW ENGL J MED, V354, P610, DOI 10.1056/NEJMra052723
   Chen AR, 2005, OBES RES, V13, P1311, DOI 10.1038/oby.2005.159
   Chen XJ, 2019, CELL DEATH DIS, V10, DOI 10.1038/s41419-019-1748-1
   CLORE GM, 1995, FASEB J, V9, P57, DOI 10.1096/fasebj.9.1.7821760
   Cramer T, 2003, CELL, V112, P645, DOI 10.1016/S0092-8674(03)00154-5
   CUSHING SD, 1990, P NATL ACAD SCI USA, V87, P5134, DOI 10.1073/pnas.87.13.5134
   Dawson J, 2003, EXPERT OPIN THER TAR, V7, P35
   Deshmane SL, 2009, J INTERF CYTOK RES, V29, P313, DOI 10.1089/jir.2008.0027
   Dewald O, 2005, CIRC RES, V96, P881, DOI 10.1161/01.RES.0000163017.13772.3a
   Engin AB, 2017, ADV EXP MED BIOL, V960, P327, DOI 10.1007/978-3-319-48382-5_14
   Erbay E, 2009, NAT MED, V15, P1383, DOI 10.1038/nm.2067
   Eto Y, 2003, J CARDIOVASC PHARM, V41, P171, DOI 10.1097/00005344-200302000-00004
   Fang WB, 2012, J BIOL CHEM, V287, P36593, DOI 10.1074/jbc.M112.365999
   Ford LB, 2014, J IMMUNOL, V193, P400, DOI 10.4049/jimmunol.1303236
   Frodermann V, 2017, EUR HEART J, V38, P198, DOI 10.1093/eurheartj/ehw085
   Fujisaka S, 2013, DIABETOLOGIA, V56, P1403, DOI 10.1007/s00125-013-2885-1
   Lopez MAG, 2009, CELL SIGNAL, V21, P1748, DOI 10.1016/j.cellsig.2009.07.010
   Ge SJ, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-171
   Georgakis MK, 2022, EUR HEART J, V43, P1799, DOI 10.1093/eurheartj/ehac094
   Georgakis MK, 2019, CIRCULATION, V139, P256, DOI 10.1161/CIRCULATIONAHA.118.035905
   Gerhardt CC, 2001, MOL CELL ENDOCRINOL, V175, P81, DOI 10.1016/S0303-7207(01)00394-X
   Gordon S, 2005, NAT REV IMMUNOL, V5, P953, DOI 10.1038/nri1733
   Gschwandtner M, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.02759
   Gu L, 1998, MOL CELL, V2, P275, DOI 10.1016/S1097-2765(00)80139-2
   Guglielmotti A, 2002, INFLAMM RES, V51, P252, DOI 10.1007/PL00000301
   Gunn MD, 1997, J IMMUNOL, V158, P376
   Gustafson B, 2009, AM J PHYSIOL-ENDOC M, V297, pE999, DOI 10.1152/ajpendo.00377.2009
   Halberg N, 2009, MOL CELL BIOL, V29, P4467, DOI 10.1128/MCB.00192-09
   Hernandez-Aguilera A, 2020, CYTOKINE, V126, DOI 10.1016/j.cyto.2019.154923
   HernandezPresa M, 1997, CIRCULATION, V95, P1532
   Hosogai N, 2007, DIABETES, V56, P901, DOI 10.2337/db06-0911
   HOTAMISLIGIL GS, 1995, J CLIN INVEST, V95, P2409, DOI 10.1172/JCI117936
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Hughes CE, 2018, FEBS J, V285, P2944, DOI 10.1111/febs.14466
   Huh JY, 2014, MOL CELLS, V37, P365, DOI 10.14348/molcells.2014.0074
   Ialenti A, 2011, ARTERIOSCL THROM VAS, V31, P2448, DOI 10.1161/ATVBAHA.111.230078
   Inouye KE, 2007, DIABETES, V56, P2242, DOI 10.2337/db07-0425
   Jiang N, 2019, FRONT MED-PRC, V13, P314, DOI 10.1007/s11684-018-0625-0
   Kaartinen MT, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21218289
   Kamei N, 2006, J BIOL CHEM, V281, P26602, DOI 10.1074/jbc.M601284200
   Kanamori H, 2007, BIOCHEM BIOPH RES CO, V360, P772, DOI 10.1016/j.bbrc.2007.06.148
   Kang YS, 2010, KIDNEY INT, V78, P883, DOI 10.1038/ki.2010.263
   Kawai T, 2021, AM J PHYSIOL-CELL PH, V320, pC375, DOI 10.1152/ajpcell.00379.2020
   Kirk EA, 2008, DIABETES, V57, P1254, DOI 10.2337/db07-1061
   Kitagawa K, 2004, AM J PATHOL, V165, P237, DOI 10.1016/S0002-9440(10)63292-0
   Kojta I, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051305
   Korbecki J, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21218412
   Krenkel O, 2018, HEPATOLOGY, V67, P1270, DOI 10.1002/hep.29544
   Kurzejamska E, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20030686
   Kuwahara F, 2004, HYPERTENSION, V43, P739, DOI 10.1161/01.HYP.0000118584.33350.7d
   Landecho MF, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112664
   Lee YS, 2014, CELL, V157, P1339, DOI 10.1016/j.cell.2014.05.012
   Libby P, 2002, NATURE, V420, P868, DOI 10.1161/ATVBAHA.108.179705
   Lin RJ, 2014, J IMMUNOL, V193, P4159, DOI 10.4049/jimmunol.1400337
   Ling ZH, 2022, CELL DEATH DIS, V13, DOI 10.1038/s41419-022-04610-5
   Lipson KL, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001648
   Liu K, 2015, AUTOPHAGY, V11, P271, DOI 10.1080/15548627.2015.1009787
   Lumeng CN, 2007, J CLIN INVEST, V117, P175, DOI 10.1172/JCI29881
   Lutgens E, 2019, EUR HEART J, V40, P3937, DOI 10.1093/eurheartj/ehz283
   Ma HX, 2022, J MOL CELL BIOL, V14, DOI 10.1093/jmcb/mjab081
   Maddaluno M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047464
   Majmudar MD, 2013, CIRCULATION, V127, P2038, DOI 10.1161/CIRCULATIONAHA.112.000116
   Mantovani A, 2004, TRENDS IMMUNOL, V25, P677, DOI 10.1016/j.it.2004.09.015
   Marchini T, 2021, FRONT CELL DEV BIOL, V9, DOI 10.3389/fcell.2021.635527
   Martire A, 2003, CARDIOVASC RES, V57, P523, DOI 10.1016/S0008-6363(02)00697-1
   Maurizi G, 2018, J CELL PHYSIOL, V233, P88, DOI 10.1002/jcp.25855
   Medzhitov R, 2008, NATURE, V454, P428, DOI 10.1038/nature07201
   MEHRABIAN M, 1991, GENOMICS, V9, P200, DOI 10.1016/0888-7543(91)90239-B
   Miller MC, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18102088
   Mirolo M, 2008, EUR CYTOKINE NETW, V19, P119, DOI 10.1684/ecn.2008.0133
   Mirzadegan T, 2000, J BIOL CHEM, V275, P25562, DOI 10.1074/jbc.M000692200
   Mora E, 2012, CELL CYCLE, V11, P159, DOI 10.4161/cc.11.1.18559
   Morimoto H, 2006, CIRC RES, V99, P891, DOI 10.1161/01.RES.0000246113.82111.2d
   NELKEN NA, 1991, J CLIN INVEST, V88, P1121, DOI 10.1172/JCI115411
   Niu JL, 2009, CLIN SCI, V117, P95, DOI 10.1042/CS20080581
   O'Rourke RW, 2011, DIABETOLOGIA, V54, P1480, DOI 10.1007/s00125-011-2103-y
   Ohtani K, 2004, GENE THER, V11, P1273, DOI 10.1038/sj.gt.3302288
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Pasarica M, 2009, DIABETES, V58, P718, DOI 10.2337/db08-1098
   Piemonti L, 2002, DIABETES, V51, P55, DOI 10.2337/diabetes.51.1.55
   Qi FF, 2021, J MOL CELL BIOL, V13, P611, DOI 10.1093/jmcb/mjab041
   Raghu H, 2017, ANN RHEUM DIS, V76, DOI 10.1136/annrheumdis-2016-210426
   Ran J, 2022, ADV SCI, V9, DOI 10.1002/advs.202105365
   Ran J, 2021, SCI BULL, V66, P1620, DOI 10.1016/j.scib.2021.02.001
   Reiling JH, 2006, ONCOGENE, V25, P6373, DOI 10.1038/sj.onc.1209889
   Rollins BJ, 1997, BLOOD, V90, P909, DOI 10.1182/blood.V90.3.909.909_909_928
   Ron D, 2007, NAT REV MOL CELL BIO, V8, P519, DOI 10.1038/nrm2199
   Rong JX, 2002, ARTERIOSCL THROM VAS, V22, P1617, DOI 10.1161/01.ATV.0000035408.93749.71
   Rull A, 2009, CYTOKINE, V48, P273, DOI 10.1016/j.cyto.2009.08.006
   Sahu B, 2023, BIOCHIMIE, V204, P92, DOI 10.1016/j.biochi.2022.09.003
   Sartipy P, 2003, P NATL ACAD SCI USA, V100, P7265, DOI 10.1073/pnas.1133870100
   Schröder M, 2005, ANNU REV BIOCHEM, V74, P739, DOI 10.1146/annurev.biochem.73.011303.074134
   Sears DD, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007250
   She SP, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.812431
   Shen ZS, 2021, CELL MOL IMMUNOL, V18, P2224, DOI 10.1038/s41423-020-0500-1
   Shimokawa H, 2003, J CARDIOVASC PHARM, V41, P372, DOI 10.1097/00005344-200303000-00005
   Shin N, 2009, BIOCHEM BIOPH RES CO, V387, P251, DOI 10.1016/j.bbrc.2009.06.135
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Snodgrass RG, 2016, J BIOL CHEM, V291, P413, DOI 10.1074/jbc.M115.686709
   STANDIFORD TJ, 1991, J BIOL CHEM, V266, P9912
   STEINBRECHER UP, 1984, P NATL ACAD SCI-BIOL, V81, P3883, DOI 10.1073/pnas.81.12.3883
   Sugimoto S, 2022, NAT METAB, V4, P775, DOI 10.1038/s42255-022-00590-0
   Sun S, 2023, SCI SIGNAL, V16, DOI 10.1126/scisignal.ade8111
   Tamura Y, 2008, ARTERIOSCL THROM VAS, V28, P2195, DOI 10.1161/ATVBAHA.108.168633
   Tamura Y, 2010, J ATHEROSCLER THROMB, V17, P219, DOI 10.5551/jat.3368
   Tan YJ, 2023, ACTA PHARMACOL SIN, DOI 10.1038/s41401-023-01189-1
   Tateya S, 2010, ENDOCRINOLOGY, V151, P971, DOI 10.1210/en.2009-0926
   Tian XY, 2023, ELIFE, V12, DOI 10.7554/eLife.87623
   Timmis A, 2018, EUR HEART J, V39, P508, DOI 10.1093/eurheartj/ehx628
   Trayhurn P, 2013, PHYSIOL REV, V93, P1, DOI 10.1152/physrev.00017.2012
   Uysal KT, 1997, NATURE, V389, P610, DOI 10.1038/39335
   Weisberg SP, 2006, J CLIN INVEST, V116, P115, DOI 10.1172/JCI24335
   Wu XB, 2018, NEUROPSYCHOPHARMACOL, V43, P2320, DOI 10.1038/s41386-018-0115-8
   Wu Y, 2023, J GENET GENOMICS, V50, P295, DOI 10.1016/j.jgg.2022.12.006
   Xie SB, 2022, ANAL CHEM, V94, P11168, DOI 10.1021/acs.analchem.2c01285
   Xie W, 2022, CELL REP, V41, DOI 10.1016/j.celrep.2022.111864
   Xu RY, 2020, PROTEIN CELL, V11, P881, DOI 10.1007/s13238-020-00739-1
   Yamashita T, 2002, ARTERIOSCL THROM VAS, V22, P969, DOI 10.1161/01.ATV.0000019051.88366.9C
   Yang H, 2020, MOL CANCER, V19, DOI 10.1186/s12943-020-01165-x
   Yang J, 2023, EMBO REP, V24, DOI 10.15252/embr.202256009
   Yang S, 2023, J GENET GENOMICS, V50, P486, DOI 10.1016/j.jgg.2023.02.003
   Yang Y, 2021, SCI BULL, V66, P727, DOI 10.1016/j.scib.2020.10.014
   Yao CC, 2019, BRIT J PHARMACOL, V176, P337, DOI 10.1111/bph.14530
   Ye JP, 2007, AM J PHYSIOL-ENDOC M, V293, pE1118, DOI 10.1152/ajpendo.00435.2007
   Yin LQ, 2020, BIOMATER SCI-UK, V8, P3640, DOI 10.1039/d0bm00418a
   Yoshimura T, 2018, CELL MOL IMMUNOL, V15, P335, DOI 10.1038/cmi.2017.135
   Yu F, 2023, ADV SCI, V10, DOI 10.1002/advs.202303545
   Zhang K, 2018, J NEUROINFLAMM, V15, DOI 10.1186/s12974-018-1241-2
   Zhang KZ, 2006, CELL, V124, P587, DOI 10.1016/j.cell.2005.11.040
   Zhao HJ, 2023, SCI BULL, V68, P2674, DOI 10.1016/j.scib.2023.09.027
   Zhu EY, 2019, LIFE SCI, V228, P72, DOI 10.1016/j.lfs.2019.04.050
   Zhu SP, 2021, J CELL PHYSIOL, V236, P7211, DOI 10.1002/jcp.30375
NR 144
TC 12
Z9 12
U1 7
U2 29
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD APR
PY 2024
VL 239
IS 4
DI 10.1002/jcp.31192
EA JAN 2024
PG 16
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA NK0F2
UT WOS:001150725400001
PM 38284280
DA 2025-06-11
ER

PT J
AU Plotogea, O
   Ilie, M
   Sandru, V
   Chiotoroiu, A
   Bratu, O
   Diaconu, C
AF Plotogea, Oana
   Ilie, Madalina
   Sandru, Vasile
   Chiotoroiu, Alexandru
   Bratu, Ovidiu
   Diaconu, Camelia
TI Cardiovascular and Metabolic Consequences of Liver Transplantation: A
   Review
SO MEDICINA-LITHUANIA
LA English
DT Review
DE liver transplantation; cardiovascular complications; metabolic
   consequences; hypertension; dyslipidemia
ID DOBUTAMINE STRESS ECHOCARDIOGRAPHY; CORONARY-ARTERY-DISEASE; AMERICAN
   ASSOCIATION; PRACTICE GUIDELINE; DIABETES-MELLITUS; BLOOD-PRESSURE;
   RISK-FACTORS; COMPLICATIONS; MORTALITY; MANAGEMENT
AB Liver transplantation (LT) is considered the curative treatment option for selected patients who suffer from end-stage or acute liver disease or hepatic malignancy (primary). After LT, patients should be carefully monitored for complications that may appear, partially due to immunosuppressive therapy, but not entirely. Cardiovascular diseases are frequently encountered in patients with LT, being responsible for high morbidity and mortality. Patients with underlying cardiovascular and metabolic pathologies are prone to complications after the transplant, but these complications can also appear de novo, mostly associated with immunosuppressants. Metabolic syndrome, defined by obesity, hypertension, dyslipidemia, and hyperglycemia, is diagnosed among LT recipients and is aggravated after LT, influencing the long-term survival. In this review, our purpose was to summarize the current knowledge regarding cardiovascular (CV) diseases and the metabolic syndrome associated with LT and to assess their impact on short and long-term morbidity and mortality.
C1 [Plotogea, Oana; Ilie, Madalina; Bratu, Ovidiu; Diaconu, Camelia] Univ Med & Pharm Carol Davila, Fac Med, Bucharest 050474, Romania.
   [Plotogea, Oana; Ilie, Madalina; Sandru, Vasile] Clin Emergency Hosp Bucharest, Gastroenterol Clin, Bucharest 014461, Romania.
   [Chiotoroiu, Alexandru] Clin Emergency Hosp Bucharest, Surg Clin, Bucharest 014461, Romania.
   [Bratu, Ovidiu] Emergency Univ, Urol Clin, Cent Mil Hosp, Bucharest 010242, Romania.
   [Diaconu, Camelia] Clin Emergency Hosp Bucharest, Internal Med Clin, Bucharest 014461, Romania.
C3 Carol Davila University of Medicine & Pharmacy
RP Diaconu, C (corresponding author), Univ Med & Pharm Carol Davila, Fac Med, Bucharest 050474, Romania.; Diaconu, C (corresponding author), Clin Emergency Hosp Bucharest, Internal Med Clin, Bucharest 014461, Romania.
EM drcameliadiaconu@gmail.com
RI Plotogea, Oana/ACS-1854-2022; Bratu, Ovidiu/L-3040-2019; Diaconu,
   Camelia/A-2144-2019; Sandru, Vasile/C-4861-2019
OI Plotogea, Oana-Mihaela/0000-0001-5730-9381; bratu,
   ovidiu/0000-0002-6971-9748; Sandru, Vasile/0000-0001-6206-6126
CR Agarwal PD, 2012, LIVER TRANSPLANT, V18, P1003, DOI 10.1002/lt.23473
   Albeldawi M, 2012, LIVER TRANSPLANT, V18, P370, DOI 10.1002/lt.22468
   [Anonymous], 2006, Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia: Report of a WHO/IDF consultation
   Artz MA, 2003, J AM SOC NEPHROL, V14, P1880, DOI 10.1097/01.ASN.0000071515.27754.67
   Barnard Abbey, 2016, Gastroenterol Hepatol (N Y), V12, P601
   Bezinover D, 2011, LIVER TRANSPLANT, V17, P324, DOI 10.1002/lt.22227
   Bianchi G, 2008, LIVER TRANSPLANT, V14, P1648, DOI 10.1002/lt.21588
   Burra P, 2016, J HEPATOL, V64, P433, DOI 10.1016/j.jhep.2015.10.006
   De Luca L, 2015, ANN GASTROENTEROL, V28, P182
   DEE GW, 1995, CLIN TRANSPLANT, V9, P463
   Dehghani SM, 2007, J GASTROENTEROL, V42, P769, DOI 10.1007/s00535-007-2092-2
   Everhart JE, 1998, LIVER TRANSPLANT SUR, V4, P285, DOI 10.1002/lt.500040402
   Farkas S, 2014, CSH PERSPECT MED, V4, DOI 10.1101/cshperspect.a015602
   Gisbert C, 1997, Liver Transpl Surg, V3, P416, DOI 10.1002/lt.500030409
   Glówczynska R, 2018, ANN TRANSPL, V23, P591, DOI [10.12659/AOT.908771, 10.12659/A0T.908771]
   Go AS, 2014, CIRCULATION, V129, pE28, DOI 10.1161/01.cir.0000441139.02102.80
   Habib S, 2006, LIVER TRANSPLANT, V12, P440, DOI 10.1002/lt.20721
   Hackl C, 2014, WORLD J GASTROENTERO, V20, P5331, DOI 10.3748/wjg.v20.i18.5331
   Harinstein ME, 2008, AM J TRANSPLANT, V8, P1523, DOI 10.1111/j.1600-6143.2008.02276.x
   Hüsing A, 2016, WORLD J GASTROENTERO, V22, P3315, DOI 10.3748/wjg.v22.i12.3315
   Jiménez-Pérez M, 2016, WORLD J GASTROENTERO, V22, P6416, DOI 10.3748/wjg.v22.i28.6416
   Kallwitz ER, 2012, WORLD J GASTROENTERO, V18, P3627, DOI 10.3748/wjg.v18.i28.3627
   Klintmalm GB, 2014, J TRANSPLANT, V2014, DOI 10.1155/2014/845438
   Kristensen SD, 2014, EUR HEART J, V35, P2383, DOI 10.1093/eurheartj/ehu282
   Kwon HM, 2018, KOREAN J ANESTHESIOL, V71, P85, DOI 10.4097/kjae.2018.71.2.85
   Laryea M, 2007, LIVER TRANSPLANT, V13, P1109, DOI 10.1002/lt.21126
   Liu HQ, 2006, WORLD J GASTROENTERO, V12, P837, DOI 10.3748/wjg.v12.i6.837
   Madhwal S, 2012, LIVER TRANSPLANT, V18, P1140, DOI 10.1002/lt.23508
   Martin P, 2014, HEPATOLOGY, V59, P1144, DOI 10.1002/hep.26972
   Martínez-Saldivar B, 2012, TRANSPLANTATION, V93, P1031, DOI 10.1097/TP.0b013e31824cd5e6
   Meirelles RF, 2015, EINSTEIN-SAO PAULO, V13, P149
   Merion RM, 2005, AM J TRANSPLANT, V5, P307, DOI 10.1111/j.1600-6143.2004.00703.x
   Miller LW, 2002, AM J TRANSPLANT, V2, P807, DOI 10.1034/j.1600-6143.2002.20902.x
   Moller S, 2008, GUT, V57, P268, DOI 10.1136/gut.2006.112177
   Moller S, 2010, J HEPATOL, V53, P179, DOI 10.1016/j.jhep.2010.02.023
   Nair S, 2002, HEPATOLOGY, V35, P105, DOI 10.1053/jhep.2002.30318
   Neal DAJ, 2004, TRANSPLANTATION, V77, P93, DOI 10.1097/01.TP.0000100685.70064.90
   Neal DAJ, 2001, LIVER TRANSPLANT, V7, P533, DOI 10.1053/jlts.2001.24637
   Nicolau-Raducu R, 2015, LIVER TRANSPLANT, V21, P13, DOI 10.1002/lt.23997
   Pagadala M, 2009, LIVER TRANSPLANT, V15, P1662, DOI 10.1002/lt.21952
   Peláez-Jaramillo MJ, 2018, DIABETES THER, V9, P521, DOI 10.1007/s13300-018-0374-8
   Pineda J, 2009, INT J CARDIOL, V136, P222, DOI 10.1016/j.ijcard.2008.04.020
   Plotkin J S, 1996, Liver Transpl Surg, V2, P426, DOI 10.1002/lt.500020604
   Rabkin JM, 2002, AM J SURG, V183, P595, DOI 10.1016/S0002-9610(02)00826-7
   Rahman S, 2015, WORLD J HEPATOL, V7, P507, DOI 10.4254/wjh.v7.i3.507
   Richards J, 2005, TRANSPL INT, V18, P461, DOI 10.1111/j.1432-2277.2004.00067.x
   Safadi A, 2009, CIRCULATION, V120, P1189, DOI 10.1161/CIRCULATIONAHA.108.847178
   Boin Ilka de Fátima Santana Ferreira, 2008, Arq. Gastroenterol., V45, P275
   Sharif A, 2014, AM J TRANSPLANT, V14, P1992, DOI 10.1111/ajt.12850
   Soule JL, 2005, AM J SURG, V189, P552, DOI 10.1016/j.amjsurg.2005.01.033
   STARZL TE, 1963, SURG GYNECOL OBSTET, V117, P659
   Starzl TE, 2012, NAT MED, V18, P1489, DOI 10.1038/nm.2927
   Steadman Randolph H, 2004, Anesthesiol Clin North Am, V22, P687, DOI 10.1016/j.atc.2004.06.009
   Therapondos G, 2004, LIVER TRANSPLANT, V10, P1441, DOI 10.1002/lt.20298
   VanWagner LB, 2016, AM J TRANSPLANT, V16, P2684, DOI 10.1111/ajt.13779
   VanWagner LB, 2014, LIVER TRANSPLANT, V20, P1306, DOI 10.1002/lt.23950
   Varma V, 2011, INT J HEPATOL, V2011, DOI 10.4061/2011/121862
   Song ATW, 2014, WORLD J GASTROENTERO, V20, P5363, DOI 10.3748/wjg.v20.i18.5363
   Watt KDS, 2010, AM J TRANSPLANT, V10, P1420, DOI 10.1111/j.1600-6143.2010.03126.x
   Williams K, 2000, TRANSPLANTATION, V69, P2354, DOI 10.1097/00007890-200006150-00023
   Zaky A, 2015, LIVER INT, V35, P12, DOI 10.1111/liv.12582
NR 61
TC 6
Z9 6
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD AUG
PY 2019
VL 55
IS 8
AR 489
DI 10.3390/medicina55080489
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IZ0GQ
UT WOS:000486769900088
PM 31443295
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Vatashchuk, MV
   Bayliak, MM
   Hurza, VV
   Storey, KB
   Lushchak, V
AF Vatashchuk, Myroslava V.
   Bayliak, Maria M.
   Hurza, Viktoria V.
   Storey, Kenneth B.
   Lushchak, Volodymyr, I
TI Metabolic Syndrome: Lessons from Rodent and Drosophila Models
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Review
ID HIGH-FAT-DIET; SELECTIVE LEPTIN RESISTANCE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; LIPID-METABOLISM; INDUCED OBESITY; ANIMAL-MODELS;
   MOUSE MODEL; RAT MODELS; RECEPTOR
AB Overweight and obesity are health conditions tightly related to a number of metabolic complications collectively called "metabolic syndrome" (MetS). Clinical diagnosis of MetS includes the presence of the increased waist circumference or so-called abdominal obesity, reduced high density lipoprotein level, elevated blood pressure, and increased blood glucose and triacylglyceride levels. Different approaches, including diet-induced and genetically induced animal models, have been developed to study MetS pathogenesis and underlying mechanisms. Studies of metabolic disturbances in the fruit fly Drosophila and mammalian models along with humans have demonstrated that fruit flies and small mammalian models like rats and mice have many similarities with humans in basic metabolic functions and share many molecular mechanisms which regulate these metabolic processes. In this paper, we describe diet-induced, chemically and genetically induced animal models of the MetS. The advantages and limitations of rodent and Drosophila models of MetS and obesity are also analyzed.
C1 [Vatashchuk, Myroslava V.; Bayliak, Maria M.; Hurza, Viktoria V.; Lushchak, Volodymyr, I] Vasyl Stefanyk Precarpathian Natl Univ, Dept Biochem & Biotechnol, 57 Shevchenko Str, UA-76018 Ivano Frankivsk, Ukraine.
   [Storey, Kenneth B.] Carleton Univ, Inst Biochem, 1125 Colonel By Dr, Ottawa, ON K1S 5B6, Canada.
   [Lushchak, Volodymyr, I] Res & Dev Univ, Shota Rustaveli Str, UA-76018 Ivano Frankivsk, Ukraine.
C3 Ministry of Education & Science of Ukraine; Vasyl Stefanyk Precarpathian
   National University; Carleton University
RP Bayliak, MM; Lushchak, V (corresponding author), Vasyl Stefanyk Precarpathian Natl Univ, Dept Biochem & Biotechnol, 57 Shevchenko Str, UA-76018 Ivano Frankivsk, Ukraine.; Lushchak, V (corresponding author), Res & Dev Univ, Shota Rustaveli Str, UA-76018 Ivano Frankivsk, Ukraine.
EM bayliak@ukr.net
RI Vatashchuk, Myroslava/JVZ-4384-2024; Storey, Kenneth/G-9883-2011;
   Lushchak, Volodymyr/AAV-4256-2021; Bayliak, Maria/P-8950-2015
OI Vatashchuk, Myroslava/0000-0001-5732-2586; Lushchak,
   Volodymyr/0000-0001-5602-3330; Hurza, Viktoriia/0000-0001-9246-2656;
   Bayliak, Maria/0000-0001-6268-8910
FU Ministry of Education and Science of Ukraine [0122U000894]; National
   Research Foundation of Ukraine [2020.02/0118]
FX This work was partially supported by a grant from the Ministry of
   Education and Science of Ukraine (#0122U000894) to VIL and a grant from
   the National Research Foundation of Ukraine (#2020.02/0118) to MMB.
CR Agrawal N, 2021, PLOS BIOL, V19, DOI 10.1371/journal.pbio.3001255
   Aguilera AA, 2004, J NUTR BIOCHEM, V15, P350, DOI 10.1016/j.jnutbio.2003.12.008
   Alberti G, 2005, EUR HEART J SUPPL, V7, pD3, DOI 10.1093/eurheartj/sui021
   Alvarez-Rendón JP, 2018, BIOMED RES INT, V2018, DOI 10.1155/2018/1417528
   Angelova P., 2013, Trakia Journal of Sciences, V11, P5
   Avtanski D, 2019, ANIM MODEL EXP MED, V2, P252, DOI 10.1002/ame2.12084
   Baenas N, 2019, GENES NUTR, V14, DOI 10.1186/s12263-019-0641-y
   Baumbach J, 2014, CELL METAB, V19, P331, DOI 10.1016/j.cmet.2013.12.004
   Bayliak M, 2020, J VASYL STEFANYK PRE, V7, P7, DOI [10.15330/JPNU.7.4.7-18, DOI 10.15330/JPNU.7.4.7-18]
   Bayliak MM, 2021, EXCLI J, V20, DOI 10.17179/excli2021-4013
   Bayliak MM, 2021, EXP GERONTOL, V145, DOI 10.1016/j.exger.2020.111182
   Bayliak MM, 2019, COMP BIOCHEM PHYS C, V217, P41, DOI 10.1016/j.cbpc.2018.11.020
   Bayliak MM, 2019, COMP BIOCHEM PHYS A, V228, P18, DOI 10.1016/j.cbpa.2018.09.027
   Belhayara MI, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030727
   Berger C, 2021, J LIPID RES, V62, DOI 10.1016/j.jlr.2021.100105
   Birse RT, 2010, CELL METAB, V12, P533, DOI 10.1016/j.cmet.2010.09.014
   Birulina JG, 2020, BYULLETEN SIB MED, V19, P14, DOI 10.20538/1682-0363-2020-4-14-20
   Bose M, 2008, J NUTR, V138, P1677, DOI 10.1093/jn/138.9.1677
   Buettner R, 2006, J MOL ENDOCRINOL, V36, P485, DOI 10.1677/jme.1.01909
   Cao H, 2016, BASIC CLIN PHARMACOL, V119, P309, DOI 10.1111/bcpt.12587
   Cao L, 2012, OXID MED CELL LONGEV, V2012, DOI 10.1155/2012/374346
   Chatterjee N, 2021, SCI ADV, V7, DOI 10.1126/sciadv.abg4336
   Chen H, 1996, CELL, V84, P491, DOI 10.1016/S0092-8674(00)81294-5
   Cheng HS, 2017, J ADV RES, V8, P743, DOI 10.1016/j.jare.2017.10.002
   Christou GA, 2019, OBES REV, V20, P805, DOI 10.1111/obr.12839
   Coogan C, 2013, DIAGNOSIS PREVENTION
   Correia MLG, 2002, DIABETES, V51, P439, DOI 10.2337/diabetes.51.2.439
   de Paula MT, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/4018157
   de-Diego I, 2020, bioRxiv, DOI [10.1101/2020.05.11.088625, 10.1101/2020.05.11.088625, DOI 10.1101/2020.05.11.088625]
   Francis D, 2021, G3-GENES GENOM GENET, V11, DOI 10.1093/g3journal/jkab171
   Fuchs Taíse, 2018, Rev. Col. Bras. Cir., V45, pe1975
   Gabery S, 2020, JCI INSIGHT, V5, DOI 10.1172/jci.insight.133429
   Gáliková M, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19071896
   Gáliková M, 2015, GENETICS, V201, P665, DOI 10.1534/genetics.115.178897
   Gallou-Kabani C, 2007, OBESITY, V15, P1996, DOI 10.1038/oby.2007.238
   Gao Y, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0240596
   Ghibaudi L, 2002, OBES RES, V10, P956, DOI 10.1038/oby.2002.130
   Gill S, 2015, SCIENCE, V347, P1265, DOI 10.1126/science.1256682
   González-Castejón M, 2011, PHARMACOL RES, V64, P438, DOI 10.1016/j.phrs.2011.07.004
   Graham P, 2017, CURR TOP DEV BIOL, V121, P397, DOI 10.1016/bs.ctdb.2016.07.011
   Grönke S, 2007, PLOS BIOL, V5, P1248, DOI 10.1371/journal.pbio.0050137
   Grönke S, 2005, CELL METAB, V1, P323, DOI 10.1016/j.cmet.2005.04.003
   Gruzdeva O, 2019, DIABET METAB SYND OB, V12, P191, DOI 10.2147/DMSO.S182406
   Guo SS, 2020, J SPORT HEALTH SCI, V9, P53, DOI 10.1016/j.jshs.2019.07.004
   Han TS., 2015, Medicine, V43, P80, DOI DOI 10.1016/J.MPMED.2014.11.006
   Harvey I, 2018, ENDOCRINOLOGY, V159, P2275, DOI 10.1210/en.2018-00147
   Heier C, 2021, BBA-MOL CELL BIOL L, V1866, DOI 10.1016/j.bbalip.2021.158924
   Heinrichsen ET, 2014, MOL METAB, V3, P42, DOI 10.1016/j.molmet.2013.10.003
   Hong SH, 2016, SCI REP-UK, V6, DOI 10.1038/srep30265
   Hsieh CC, 2016, J FOOD DRUG ANAL, V24, P754, DOI 10.1016/j.jfda.2016.03.005
   Huang T, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.790414
   Jia YJ, 2013, J GERIATR CARDIOL, V10, P361, DOI 10.3969/j.issn.1671-5411.2013.04.007
   Johnson RJ, 2013, DIABETES, V62, P3307, DOI 10.2337/db12-1814
   Jürgens H, 2005, OBES RES, V13, P1146, DOI 10.1038/oby.2005.136
   Kanasaki K, 2011, J BIOMED BIOTECHNOL, DOI 10.1155/2011/197636
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Keim N.L., 2013, Encycl. Hum. Nutr, V2, P361, DOI DOI 10.1016/B978-0-12-375083-9.00128-8
   Kennedy AJ, 2010, DIS MODEL MECH, V3, P156, DOI 10.1242/dmm.003467
   Kwitek AE, 2019, METHODS MOL BIOL, V2018, P269, DOI 10.1007/978-1-4939-9581-3_13
   Lackey DE, 2016, AM J PHYSIOL-ENDOC M, V311, pE989, DOI 10.1152/ajpendo.00323.2016
   Lee GH, 1996, NATURE, V379, P632, DOI 10.1038/379632a0
   Lee SJ, 2022, AGING-US, V14, P225, DOI 10.18632/aging.203821
   Lee WC, 2018, BIOMED J, V41, P96, DOI 10.1016/j.bj.2018.02.006
   Leopold P, 2007, NATURE, V450, P186, DOI 10.1038/nature06286
   Li LZ, 2015, ENDOCRINE, V49, P659, DOI 10.1007/s12020-015-0542-9
   Mahmoud AAA, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0106993
   Mamikutty N, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/263897
   Marmugi A, 2012, HEPATOLOGY, V55, P395, DOI 10.1002/hep.24685
   Mattson MP, 2017, AGEING RES REV, V39, P46, DOI 10.1016/j.arr.2016.10.005
   Meehan TP, 2006, MAMM GENOME, V17, P1162, DOI 10.1007/s00335-006-0073-z
   Mehta M, 2021, ENDOCR PRACT, V27, P626, DOI 10.1016/j.eprac.2021.04.001
   MICHAUD EJ, 1994, P NATL ACAD SCI USA, V91, P2562, DOI 10.1073/pnas.91.7.2562
   Moreno-Fernández S, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101502
   Mueller LD, 2015, GENETICA, V143, P93, DOI 10.1007/s10709-015-9818-5
   Müller TD, 2022, NAT REV DRUG DISCOV, V21, P201, DOI 10.1038/s41573-021-00337-8
   Murillo-Maldonado JM, 2011, DIABETES, V60, P1632, DOI 10.2337/db10-1288
   Musselman LP, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0217096
   Musselman LP, 2018, J EXP BIOL, V221, DOI 10.1242/jeb.163881
   Musselman LP, 2011, DIS MODEL MECH, V4, P842, DOI 10.1242/dmm.007948
   Nazario-Yepiz NO, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0255198
   Nunes-Souza V, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/1987960
   Oron-Herman M, 2008, AM J HYPERTENS, V21, P1018, DOI 10.1038/ajh.2008.218
   Palu RAS, 2017, MOL METAB, V6, P631, DOI 10.1016/j.molmet.2017.03.012
   Pang XF, 2008, J ETHNOPHARMACOL, V117, P325, DOI 10.1016/j.jep.2008.02.002
   Parikh Rakesh M, 2012, Indian J Endocrinol Metab, V16, P7, DOI 10.4103/2230-8210.91175
   Partridge L, 2005, MECH AGEING DEV, V126, P938, DOI 10.1016/j.mad.2005.03.023
   Pelletier RM, 2018, AM J PHYSIOL-ENDOC M, V314, pE21, DOI 10.1152/ajpendo.00215.2017
   Pérez-Torres I, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22041786
   Petryn T.S., 2021, STUD BIOL, V15, P3, DOI [10.30970/SBI.1501.642, 10.30970/sbi.1501.642]
   Piattini F, 2019, MOL METAB, V25, P131, DOI 10.1016/j.molmet.2019.04.010
   Pontes-da-Silva RM, 2022, INT J OBESITY, V46, P21, DOI 10.1038/s41366-021-00955-7
   Pospisilik JA, 2010, CELL, V140, P148, DOI 10.1016/j.cell.2009.12.027
   Qiu S, 2022, J MED FOOD, V25, P313, DOI 10.1089/jmf.2021.K.0163
   Rahmouni K, 2005, DIABETES, V54, P2012, DOI 10.2337/diabetes.54.7.2012
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Rodríguez-Correa E, 2020, NUTR DIABETES, V10, DOI 10.1038/s41387-020-0127-4
   Rovenko BM, 2015, J INSECT PHYSIOL, V79, P42, DOI 10.1016/j.jinsphys.2015.05.007
   Rovenko BM, 2015, COMP BIOCHEM PHYS A, V187, P27, DOI 10.1016/j.cbpa.2015.04.012
   Rovenko BM, 2015, COMP BIOCHEM PHYS A, V180, P75, DOI 10.1016/j.cbpa.2014.11.008
   Sadowska J, 2017, ACTA SCI POLON-TECHN, V16, P231, DOI [10.17306/J.AFS.2017.0482, 10.17306/J.AFS.0482]
   Samy DM, 2021, LIFE SCI, V284, DOI 10.1016/j.lfs.2021.119897
   Schultz A, 2013, INT J MOL SCI, V14, P21873, DOI 10.3390/ijms141121873
   Scott NJA, 2012, AM J PHYSIOL-ENDOC M, V302, pE576, DOI 10.1152/ajpendo.00222.2011
   Semaniuk U, 2021, ENTOMOL EXP APPL, V169, P195, DOI 10.1111/eea.12981
   Semaniuk UV, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01083
   Semchyshyn HM, 2014, CARBOHYD RES, V384, P61, DOI 10.1016/j.carres.2013.11.015
   Semchyshyn HM, 2011, CARBOHYD RES, V346, P933, DOI 10.1016/j.carres.2011.03.005
   Simonson M, 2020, REV ENDOCR METAB DIS, V21, P341, DOI 10.1007/s11154-020-09574-5
   Sommer AJ, 2019, APPL ENVIRON MICROB, V85, DOI 10.1128/AEM.01882-18
   Speakman J, 2008, LAB ANIM-UK, V42, P413, DOI 10.1258/la.2007.006067
   Suriano F, 2021, MICROBIOME, V9, DOI 10.1186/s40168-021-01097-8
   Taskinen MR, 2019, NUTRIENTS, V11, DOI 10.3390/nu11091987
   The Jackson Laboratory, 2022, US
   Nguyen TLA, 2015, DIS MODEL MECH, V8, P1, DOI 10.1242/dmm.017400
   Thomsen SK, 2016, DIABETES, V65, P3805, DOI 10.2337/db16-0361
   Villanueva JE, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-10563-9
   Wang BX, 2014, CURR DIABETES REV, V10, P131, DOI 10.2174/1573399810666140508121012
   Wang PX, 2020, CHINESE MED J-PEKING, V133, P808, DOI 10.1097/CM9.0000000000000696
   Warden CH, 2008, CELL METAB, V7, P277, DOI 10.1016/j.cmet.2008.03.014
   Wassenaar PNH, 2017, CHEMOSPHERE, V188, P174, DOI 10.1016/j.chemosphere.2017.08.165
   Weidner C, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0080335
   Wen Deng-Tai, 2018, Oncotarget, V9, P7298, DOI 10.18632/oncotarget.23292
   Wharton S, 2018, DIABET METAB SYND OB, V11, P427, DOI 10.2147/DMSO.S171365
   Williams MJ, 2016, ENDOCRINOLOGY, V157, P2309, DOI 10.1210/en.2015-2006
   Williams MJ, 2014, BASIC CLIN PHARMACOL, V114, P414, DOI 10.1111/bcpt.12170
   Wong SK, 2018, EXP CLIN ENDOCR DIAB, V126, P205, DOI 10.1055/s-0043-119352
   Wong SK, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0123-9
   Woods SC, 2003, J NUTR, V133, P1081, DOI 10.1093/jn/133.4.1081
   Xie K, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00178-3
   Yang K, 2011, CHEM-BIOL INTERACT, V191, P315, DOI 10.1016/j.cbi.2011.02.027
   ZHANG YY, 1994, NATURE, V372, P425, DOI 10.1038/372425a0
NR 131
TC 12
Z9 13
U1 1
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PD JUN 22
PY 2022
VL 2022
AR 5850507
DI 10.1155/2022/5850507
PG 13
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 5N7EG
UT WOS:000871950300001
PM 35782067
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Gasmi, A
   Mujawdiya, PK
   Noor, S
   Lysiuk, R
   Darmohray, R
   Piscopo, S
   Lenchyk, L
   Antonyak, H
   Dehtiarova, K
   Shanaida, M
   Polishchuk, A
   Shanaida, V
   Peana, M
   Bjorklund, G
AF Gasmi, Amin
   Mujawdiya, Pavan Kumar
   Noor, Sadaf
   Lysiuk, Roman
   Darmohray, Roman
   Piscopo, Salva
   Lenchyk, Larysa
   Antonyak, Halyna
   Dehtiarova, Kateryna
   Shanaida, Mariia
   Polishchuk, Alexandr
   Shanaida, Volodymyr
   Peana, Massimiliano
   Bjorklund, Geir
TI Polyphenols in Metabolic Diseases
SO MOLECULES
LA English
DT Review
DE phenolic compounds; natural sources; metabolic syndrome; bioprotective
   property; therapeutic effect
ID INDUCED INSULIN-RESISTANCE; SALVIANOLIC-ACID-B; OXIDATIVE STRESS;
   DIETARY POLYPHENOLS; IN-VITRO; RED WINE; MYOCARDIAL-INFARCTION;
   ANTIOXIDANT ACTIVITY; PHENOLIC-COMPOUNDS; GRAPE POLYPHENOLS
AB Polyphenols (PPs) are a large group of phytochemicals containing phenolic rings with two or more hydroxyl groups. They possess powerful antioxidant properties, multiple therapeutic effects, and possible health benefits in vivo and in vitro, as well as reported clinical studies. Considering their free-radical scavenging and anti-inflammatory properties, these substances can be used to treat different kinds of conditions associated with metabolic disorders. Many symptoms of metabolic syndrome (MtS), including obesity, dyslipidemia, atherosclerosis, elevated blood sugar, accelerating aging, liver intoxication, hypertension, as well as cancer and neurodegenerative disorders, are substantially relieved by dietary PPs. The present study explores the bioprotective properties and associated underlying mechanisms of PPs. A detailed understanding of these natural compounds will open up new opportunities for producing unique natural PP-rich dietary and medicinal plans, ultimately affirming their health benefits.
C1 [Gasmi, Amin; Piscopo, Salva] Soc Francophone Nutritherapie & Nutrigenet Appl, F-69100 Villeurbanne, France.
   [Gasmi, Amin] Univ Claude Bernard, Lab Interuniv Biol Motricite, F-69100 Villeurbanne, France.
   [Mujawdiya, Pavan Kumar] Birla Inst Technol & Sci Pilani, Hyderabad 500078, India.
   [Noor, Sadaf] Bahauddin Zakariya Univ, Inst Mol Biol & Biotechnol, Multan 60800, Pakistan.
   [Lysiuk, Roman; Darmohray, Roman] Danylo Halytsky Lviv Natl Med Univ, Dept Pharmacognosy & Bot, UA-79010 Lvov, Ukraine.
   [Lysiuk, Roman; Darmohray, Roman] Danylo Halytsky Lviv Natl Med Univ, CONEM Ukraine Life Sci Res Grp, UA-79010 Lvov, Ukraine.
   [Lenchyk, Larysa; Dehtiarova, Kateryna] Natl Univ Pharm, Inst Adv Training Pharm Specialist, UA-61001 Kharkiv, Ukraine.
   [Lenchyk, Larysa; Dehtiarova, Kateryna] Natl Univ Pharm, CONEM Ukraine Pharmacognosy & Nat Prod Chem Res G, UA-61002 Kharkiv, Ukraine.
   [Antonyak, Halyna; Polishchuk, Alexandr] Ivan Franko Natl Univ Lviv, Dept Ecol, UA-79005 Lvov, Ukraine.
   [Shanaida, Mariia] I Horbachevsky Ternopil Natl Med Univ, Dept Pharmacognosy & Med Bot, UA-46001 Ternopol, Ukraine.
   [Shanaida, Volodymyr] Ternopil Ivan Puluj Natl Tech Univ, Design Machine Tools Instruments & Machines Dept, UA-46001 Ternopol, Ukraine.
   [Peana, Massimiliano] Univ Sassari, Dept Chem Phys Math & Nat Sci, Via Vienna 2, I-07100 Sassari, Italy.
   [Bjorklund, Geir] Council Nutr & Environm Med CONEM, N-8610 Mo I Rana, Norway.
C3 Universite Claude Bernard Lyon 1; Birla Institute of Technology &
   Science Pilani (BITS Pilani); Bahauddin Zakariya University; Danylo
   Halytsky Lviv National Medical University; Danylo Halytsky Lviv National
   Medical University; National University of Pharmacy; National University
   of Pharmacy; Ministry of Education & Science of Ukraine; Ivan Franko
   National University Lviv; I. Horbachevsky Ternopil State Medical
   University; Ministry of Education & Science of Ukraine; Ternopil Ivan
   Puluj National Technical University; University of Sassari
RP Bjorklund, G (corresponding author), Council Nutr & Environm Med CONEM, N-8610 Mo I Rana, Norway.
EM bjorklund@conem.org
RI Mujawdiya, Pavan/HJG-7443-2022; Lysiuk, Roman/O-1030-2019; Noor,
   Sadaf/KIA-8696-2024; Shanaida, Volodymyr/AAE-2318-2019; Gasmi,
   Amin/AAL-3595-2020; Lenchyk, Larysa/JCO-4374-2023; Polishchuk,
   Olexandr/AAV-3186-2021; Shanaida, Mariia/AAD-3256-2020; Antonyak,
   Halyna/I-6308-2015; Bjorklund, Geir/B-7319-2014; Peana, Massimiliano
   Francesco/B-6854-2014
OI Lysiuk, Roman/0000-0003-0961-2970; Mujawdiya, Pavan/0000-0003-2437-1263;
   Shanaida, Mariia/0000-0003-1070-6739; Antonyak,
   Halyna/0000-0002-1640-737X; Bjorklund, Geir/0000-0003-2632-3935; Noor,
   Sadaf/0000-0002-4153-7547; Gasmi, Amin/0000-0003-2165-8373; Peana,
   Massimiliano Francesco/0000-0002-3306-0419
CR Abdelmoez W, 2017, WATER EXTRACTION OF BIOACTIVE COMPOUNDS: FROM PLANTS TO DRUG DEVELOPMENT, P51, DOI 10.1016/B978-0-12-809380-1.00002-4
   Afaq F, 2011, MINI-REV MED CHEM, V11, P1200
   Agunloye OM, 2019, BIOMED PHARMACOTHER, V109, P450, DOI 10.1016/j.biopha.2018.10.044
   Ahamad J, 2019, PHYTOTHER RES, V33, P3112, DOI 10.1002/ptr.6511
   Aires A, 2016, WASTE MANAGE, V48, P457, DOI 10.1016/j.wasman.2015.11.019
   Alam MA, 2014, ADV NUTR, V5, P404, DOI 10.3945/an.113.005603
   Alam M, 2022, FOOD CHEM, V379, DOI 10.1016/j.foodchem.2022.132135
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Anderson RA, 2008, P NUTR SOC, V67, P48, DOI 10.1017/S0029665108006010
   Martín MA, 2021, NUTRIENTS, V13, DOI 10.3390/nu13030850
   Martín MA, 2016, J FUNCT FOODS, V27, P570, DOI 10.1016/j.jff.2016.10.008
   Anhê FF, 2015, GUT, V64, P872, DOI 10.1136/gutjnl-2014-307142
   Anusuya C, 2011, J ENVIRON PATHOL TOX, V30, P199, DOI 10.1615/JEnvironPatholToxicolOncol.v30.i3.30
   Babu PVA, 2006, CLIN EXP PHARMACOL P, V33, P1184, DOI 10.1111/j.1440-1681.2006.04509.x
   Baer-Dubowska W, 2013, EXPERT OPIN DRUG MET, V9, P927, DOI 10.1517/17425255.2013.795219
   Bahadoran Z, 2013, J DIABETES METAB DIS, V12, DOI 10.1186/2251-6581-12-43
   Barbosa M, 2020, MAR DRUGS, V18, DOI 10.3390/md18120654
   Beconcini D, 2020, FOODS, V9, DOI 10.3390/foods9020207
   Behl T, 2020, BIOMED PHARMACOTHER, V130, DOI 10.1016/j.biopha.2020.110714
   Biesalski HK, 2007, CURR OPIN CLIN NUTR, V10, P724, DOI 10.1097/MCO.0b013e3282f0cef2
   Biglu MH, 2016, J CARDIOVASC THORAC, V8, P158, DOI 10.15171/jcvtr.2016.32
   Bjorklund G, 2018, BASIC CLIN PHARMACOL, V122, P539, DOI 10.1111/bcpt.12972
   Bjorklund G, 2017, FOOD CHEM TOXICOL, V110, P240, DOI 10.1016/j.fct.2017.10.039
   Black PH, 2002, BRAIN BEHAV IMMUN, V16, P622, DOI 10.1016/S0889-1591(02)00021-1
   Bonnefont-Rousselot D, 2016, NUTRIENTS, V8, DOI 10.3390/nu8050250
   Bouyahya A, 2022, MOLECULES, V27, DOI 10.3390/molecules27103286
   Brahmbhatt M, 2013, NUTR CANCER, V65, P263, DOI 10.1080/01635581.2013.749925
   Bravo L, 1998, NUTR REV, V56, P317, DOI 10.1111/j.1753-4887.1998.tb01670.x
   Brown AL, 2009, BRIT J NUTR, V101, P886, DOI 10.1017/S0007114508047727
   Bugianesi R, 2002, J NUTR, V132, P3349, DOI 10.1093/jn/132.11.3349
   Burns J, 2002, J AGR FOOD CHEM, V50, P3337, DOI 10.1021/jf0112973
   Cao GH, 1997, FREE RADICAL BIO MED, V22, P749, DOI 10.1016/S0891-5849(96)00351-6
   Capomolla AS, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061271
   Castanon N., 2006, INFLAMMATION SICKNES, P265, DOI [10.1017/cbo9780511544293.013, DOI 10.1017/CBO9780511544293.013]
   Catalgol B, 2012, PROG MOL BIOL TRANSL, V109, P277, DOI 10.1016/B978-0-12-397863-9.00008-0
   Cattuzzato L, 2019, U.S. Patent, Patent No. 10206869
   Chan MMY, 2000, BIOCHEM PHARMACOL, V60, P1539, DOI 10.1016/S0006-2952(00)00471-8
   Chao PC, 2009, NUTR METAB, V6, DOI 10.1186/1743-7075-6-33
   Chen C, 2012, LIFE SCI, V90, P721, DOI 10.1016/j.lfs.2012.03.008
   Chen JF, 2014, BASIC CLIN PHARMACOL, V114, P293, DOI 10.1111/bcpt.12153
   Chen L, 2021, FOOD FUNCT, V12, P2378, DOI [10.1039/d0fo02886j, 10.1039/D0FO02886J]
   Chen LY, 2022, FOOD RES INT, V151, DOI 10.1016/j.foodres.2022.111202
   Chiva-Blanch G, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/5812401
   Cipolletti M, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19092624
   Conte R., 2016, J BIOMOL RES THER, V5, P1000139, DOI DOI 10.4172/2167-7956.1000139
   Cory H, 2018, FRONT NUTR, V5, DOI 10.3389/fnut.2018.00087
   Costa C, 2017, FOOD CHEM TOXICOL, V110, P286, DOI 10.1016/j.fct.2017.10.023
   Costa LG, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/2986796
   Cowan MM, 1999, CLIN MICROBIOL REV, V12, P564, DOI 10.1128/CMR.12.4.564
   Dabke K, 2019, J CLIN INVEST, V129, P4050, DOI 10.1172/JCI129194
   Das SS, 2020, POLYMERS-BASEL, V12, DOI 10.3390/polym12061397
   Das Samarjit, 2007, Inflammation & Allergy Drug Targets, V6, P168, DOI 10.2174/187152807781696464
   David B, 2015, PHYTOCHEM REV, V14, P299, DOI 10.1007/s11101-014-9367-z
   de Oca MKM, 2017, PHOTOCHEM PHOTOBIOL, V93, P956, DOI 10.1111/php.12711
   de Souza PL, 2010, NUTR REV, V68, P542, DOI 10.1111/j.1753-4887.2010.00314.x
   Demeule Michel, 2002, Current Medicinal Chemistry - Anti-Cancer Agents, V2, P441, DOI 10.2174/1568011023353930
   Do YK, 2009, J MOL CATAL B-ENZYM, V56, P173, DOI 10.1016/j.molcatb.2008.08.003
   Dodevska M, 2015, J SERB CHEM SOC, V80, P21, DOI 10.2298/JSC140407062D
   Domitrovic R, 2016, ARCH TOXICOL, V90, P39, DOI 10.1007/s00204-015-1580-z
   Duarte L, 2021, REV ENDOCR METAB DIS, V22, P367, DOI 10.1007/s11154-020-09622-0
   Dulloo AG, 1999, AM J CLIN NUTR, V70, P1040
   Durazzo A, 2020, FOODS, V9, DOI 10.3390/foods9030370
   Durazzo A, 2019, PHYTOTHER RES, V33, P2221, DOI 10.1002/ptr.6419
   Durazzo A, 2019, MOLECULES, V24, DOI 10.3390/molecules24101933
   el-Din SHS, 2016, J ADV PHARM TECHNOL, V7, P99, DOI 10.4103/2231-4040.184594
   Erpel F, 2020, FOOD RES INT, V137, DOI 10.1016/j.foodres.2020.109589
   Fan XL, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23042176
   Farias DD, 2021, FOOD RES INT, V145, DOI 10.1016/j.foodres.2021.110383
   Federico A, 2017, MOLECULES, V22, DOI 10.3390/molecules22020191
   Feldman F, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020672
   Femia AP, 2005, EUR J NUTR, V44, P79, DOI 10.1007/s00394-004-0496-9
   Ferenczyova K, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21051585
   Finicelli M, 2019, J CELL PHYSIOL, V234, P5807, DOI 10.1002/jcp.27506
   Finkelstein EA, 2012, AM J PREV MED, V42, P563, DOI 10.1016/j.amepre.2011.10.026
   Forshew T, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3003726
   García-Aguilar A, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10020142
   Gasmi A, 2022, PHARMACEUTICALS-BASE, V15, DOI 10.3390/ph15091049
   Ghurghure SM, 2018, Int J Chem Studies, V2
   Glevitzky I, 2019, REV CHIM-BUCHAREST, V70, P3103
   Gollucke APB, 2013, J MED FOOD, V16, P199, DOI 10.1089/jmf.2012.0170
   Gonçalves D, 2017, FOOD NUTR RES, V61, DOI 10.1080/16546628.2017.1296675
   González R, 2011, CRIT REV FOOD SCI, V51, P331, DOI 10.1080/10408390903584094
   GRANT DM, 1991, J INHERIT METAB DIS, V14, P421, DOI 10.1007/BF01797915
   Gu W, 2022, INT J CLIN PRACT, V2022, DOI 10.1155/2022/9734738
   GUGLER R, 1975, EUR J CLIN PHARMACOL, V9, P229, DOI 10.1007/BF00614022
   Gulcin I, 2020, ARCH TOXICOL, V94, P651, DOI 10.1007/s00204-020-02689-3
   Gundala SR, 2013, CARCINOGENESIS, V34, P2039, DOI 10.1093/carcin/bgt141
   Guo XH, 2017, NUTRIENTS, V9, DOI 10.3390/nu9050452
   Haraguchi H, 1998, PHYTOCHEMISTRY, V48, P125, DOI 10.1016/S0031-9422(97)01105-9
   He HB, 2008, J ETHNOPHARMACOL, V118, P35, DOI 10.1016/j.jep.2008.03.006
   Heim KE, 2002, J NUTR BIOCHEM, V13, P572, DOI 10.1016/S0955-2863(02)00208-5
   Hitl M, 2021, PLANTA MED, V87, P273, DOI 10.1055/a-1301-8648
   Hodges RE, 2015, J NUTR METAB, V2015, DOI 10.1155/2015/760689
   Hokayem M, 2013, DIABETES CARE, V36, P1454, DOI 10.2337/dc12-1652
   HOLLMAN PCH, 1995, AM J CLIN NUTR, V62, P1276, DOI 10.1093/ajcn/62.6.1276
   Homey B, 2006, J ALLERGY CLIN IMMUN, V118, P178, DOI 10.1016/j.jaci.2006.03.047
   Hou CY, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20030535
   Hu M, 2017, MOL PHARMACEUT, V14, P2861, DOI 10.1021/acs.molpharmaceut.7b00545
   Hussain A, 2021, MOLECULES, V26, DOI 10.3390/molecules26020302
   Ibitoye OB, 2018, ARCH PHYSIOL BIOCHEM, V124, P410, DOI 10.1080/13813455.2017.1415938
   Izumi T, 2000, J NUTR, V130, P1695, DOI 10.1093/jn/130.7.1695
   Jabczyk M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124440
   Jagetia G.C., 2014, J MOL BIOCH, V3, P34
   Jang HJ, 2013, AM J PHYSIOL-ENDOC M, V305, pE1444, DOI 10.1152/ajpendo.00434.2013
   Jasicka-Misiak I, 2021, FOODS, V10, DOI 10.3390/foods10123063
   Jean-Marie E, 2021, FOODS, V10, DOI 10.3390/foods10092049
   Jones DP, 2006, ANTIOXID REDOX SIGN, V8, P1865, DOI 10.1089/ars.2006.8.1865
   Kannappan S, 2009, INDIAN J MED RES, V129, P401
   Kanwar Jyoti, 2012, Front Biosci (Elite Ed), V4, P111
   KASPRZYCKAGUTTMAN T, 1994, THERMOCHIM ACTA, V231, P161, DOI 10.1016/0040-6031(94)80018-9
   Kaviarasan S, 2007, PHARMAZIE, V62, P299, DOI 10.1691/ph.2007.4.6648
   Keen CL, 2005, AM J CLIN NUTR, V81, p298S, DOI 10.1093/ajcn/81.1.298S
   Kerry NL, 1997, ATHEROSCLEROSIS, V135, P93, DOI 10.1016/S0021-9150(97)00156-1
   Khoo HE, 2017, FOOD NUTR RES, V61, P1, DOI 10.1080/16546628.2017.1361779
   Kishimoto Y, 2013, EUR J CLIN NUTR, V67, P532, DOI 10.1038/ejcn.2013.29
   Klaunig JE, 2010, TOXICOL PATHOL, V38, P96, DOI 10.1177/0192623309356453
   Kleemann R, 2011, ATHEROSCLEROSIS, V218, P44, DOI 10.1016/j.atherosclerosis.2011.04.023
   Kong S, 2010, FOOD CHEM, V120, P278, DOI 10.1016/j.foodchem.2009.09.089
   Kuczynska-Wisnik D, 2010, RES MICROBIOL, V161, P847, DOI 10.1016/j.resmic.2010.09.012
   Kumar SR, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/9752826
   Kurin E, 2012, PLANTA MED, V78, P772, DOI 10.1055/s-0031-1298440
   Labinskyy N, 2006, CURR MED CHEM, V13, P989, DOI 10.2174/092986706776360987
   Larsson SC, 2016, HEART, V102, P1017, DOI 10.1136/heartjnl-2015-309203
   Lee CH, 2012, BIOSCI BIOTECH BIOCH, V76, P646, DOI 10.1271/bbb.110579
   Lee CW, 2012, J AGR FOOD CHEM, V60, P4662, DOI 10.1021/jf2050137
   Leri M, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21041250
   Leroux C, 2014, CAN J DIABETES, V38, P62, DOI 10.1016/j.jcjd.2013.08.268
   Lewandowska U, 2014, POSTEP HIG MED DOSW, V68, P528, DOI 10.5604/17322693.1102278
   Li AN, 2014, NUTRIENTS, V6, P6020, DOI 10.3390/nu6126020
   Li LJ, 2015, DRUG DISCOV TODAY, V20, P1074, DOI 10.1016/j.drudis.2015.04.009
   Li S, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/8394818
   Liao CC, 2017, AM J CHINESE MED, V45, P105, DOI 10.1142/S0192415X17500082
   Lim DW, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1121-1
   Limanaqi F, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9101022
   Lin R, 2020, J IMMUNOL RES, V2020, DOI 10.1155/2020/9242601
   Lin XC, 2016, J NUTR, V146, P2325, DOI 10.3945/jn.116.237644
   Little R, 2020, MOL NUTR FOOD RES, V64, DOI 10.1002/mnfr.202000034
   Liu C, 2019, FOOD FUNCT, V10, P2061, DOI 10.1039/c8fo02334d
   Liu JK, 2002, CURR MED CHEM, V9, P1483, DOI 10.2174/0929867023369709
   Liu W, 2012, ASIAN PAC J CANCER P, V13, P2409, DOI 10.7314/APJCP.2012.13.5.2409
   Londhe JS, 2012, FITOTERAPIA, V83, P1562, DOI 10.1016/j.fitote.2012.09.003
   Lopaciuk A., 2013, P MAN KNOWL LEARN IN, P19
   Loureiro JA, 2017, MOLECULES, V22, DOI 10.3390/molecules22020277
   Luo MJ, 2020, J AGR FOOD CHEM, V68, P10875, DOI 10.1021/acs.jafc.0c03907
   Luo YY, 2020, J BUON, V25, P1245
   Lyons CL, 2016, NUTRIENTS, V8, DOI 10.3390/nu8050247
   Madureira AR, 2016, INT J NANOMED, V11, P3621, DOI 10.2147/IJN.S104623
   Mankowski RT, 2020, EXP GERONTOL, V131, DOI 10.1016/j.exger.2019.110821
   Mathew A., 2011, 2011 IEEE 11th International Conference on Nanotechnology (IEEE-NANO), P833, DOI 10.1109/NANO.2011.6144336
   Matsuno Y, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-62292-5
   McCarty MF, 2005, MED HYPOTHESES, V64, P628, DOI 10.1016/j.mehy.2003.11.042
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   Mehmood A, 2020, FOOD SCI NUTR, V8, P4639, DOI 10.1002/fsn3.1668
   Menon VP, 2007, ADV EXP MED BIOL, V595, P105
   Meydani M, 2010, NUTRIENTS, V2, P737, DOI 10.3390/nu2070737
   Milincic DD, 2019, NANOMATERIALS-BASEL, V9, DOI 10.3390/nano9111629
   Mishra AK, 2009, ANN CLIN MICROB ANTI, V8, DOI 10.1186/1476-0711-8-9
   Mokhtari M., 2017, THESIS VICTORIA U WE
   Molinari R, 2022, BIOFACTORS, V48, P255, DOI 10.1002/biof.1772
   MORI A, 1987, PHYTOCHEMISTRY, V26, P2231, DOI 10.1016/S0031-9422(00)84689-0
   Morré DJ, 2003, PHARMACOL TOXICOL, V92, P234, DOI 10.1034/j.1600-0773.2003.920506.x
   Morré DM, 2006, CANCER LETT, V238, P202, DOI 10.1016/j.canlet.2005.07.011
   Kadar NNMA, 2021, MOLECULES, V26, DOI 10.3390/molecules26185490
   Mukund V, 2017, CRIT REV ONCOL HEMAT, V119, P13, DOI 10.1016/j.critrevonc.2017.09.004
   Mykhailenko O, 2019, PHYTOCHEMISTRY, V162, P56, DOI 10.1016/j.phytochem.2019.02.004
   Nagata C, 2010, J EPIDEMIOL, V20, P83, DOI 10.2188/jea.JE20090181
   Nani A, 2021, MOLECULES, V26, DOI 10.3390/molecules26040985
   Naseri R, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01310
   Niess AC, 1999, EXERC IMMUNOL REV, V5, P22
   Niewiadomska J, 2022, BIOLOGY-BASEL, V11, DOI 10.3390/biology11040559
   Nyandwi JB, 2021, BIOMOLECULES, V11, DOI 10.3390/biom11101470
   Oak MH, 2005, J NUTR BIOCHEM, V16, P1, DOI 10.1016/j.jnutbio.2004.09.004
   Obrenovich ME, 2010, REJUV RES, V13, P631, DOI 10.1089/rej.2010.1043
   Osali A, 2020, DIABETOL METAB SYNDR, V12, DOI 10.1186/s13098-020-00532-4
   Osawa T, 1999, MECH AGEING DEV, V111, P133, DOI 10.1016/S0047-6374(99)00069-X
   Pandey AK, 2012, CELL MOL BIOL, V58, P142, DOI 10.1170/T933
   Pangeni R, 2014, NANOTECHNOLOGY, V25, DOI 10.1088/0957-4484/25/48/485102
   Pannala AS, 2001, BIOCHEM BIOPH RES CO, V282, P1161, DOI 10.1006/bbrc.2001.4705
   Papaevgeniou N, 2018, CURR PHARM DESIGN, V24, P2107, DOI 10.2174/1381612824666180515145652
   Pasparakis M, 2014, NAT REV IMMUNOL, V14, P289, DOI 10.1038/nri3646
   Pérez YY, 2007, AM J CHINESE MED, V35, P1037, DOI 10.1142/S0192415X07005491
   Petti S, 2009, J DENT, V37, P413, DOI 10.1016/j.jdent.2009.02.003
   Peyrol J, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030306
   Pourhabibi-Zarandi F, 2022, PHYTOTHER RES, V36, P1797, DOI 10.1002/ptr.7422
   Quispe C, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/3149223
   Ranneh Y, 2021, BMC COMPLEMENT MED, V21, DOI 10.1186/s12906-020-03170-5
   Rao S, 2018, NUTR CANCER, V70, P913, DOI 10.1080/01635581.2018.1491609
   Rasines-Perea Z, 2017, MOLECULES, V22, DOI 10.3390/molecules22010068
   RATTY AK, 1988, BIOCHEM MED METAB B, V39, P69, DOI 10.1016/0885-4505(88)90060-6
   Ratz-Lyko A, 2015, PHYTOTHER RES, V29, P509, DOI 10.1002/ptr.5289
   Reis JP, 2010, ARTERIOSCL THROM VAS, V30, P2059, DOI 10.1161/ATVBAHA.110.208280
   RiceEvans CA, 1996, FREE RADICAL BIO MED, V20, P933, DOI 10.1016/0891-5849(95)02227-9
   Rodríguez-Ramiro I, 2013, BRIT J NUTR, V110, P206, DOI 10.1017/S0007114512004862
   Rodríguez-Vera D, 2022, NEURAL REGEN RES, V17, P2093, DOI 10.4103/1673-5374.335826
   Romagnolo Donato F, 2017, Nutr Today, V52, P208, DOI 10.1097/NT.0000000000000228
   Ross JA, 2002, ANNU REV NUTR, V22, P19, DOI 10.1146/annurev.nutr.22.111401.144957
   Russo GL, 2020, BIOCHEM PHARMACOL, V173, DOI 10.1016/j.bcp.2019.113719
   Rytsyk O, 2020, NAT PROD COMMUN, V15, P1, DOI 10.1177/1934578X20932742
   Saague Peter William Kemewele, 2019, ScientificWorldJournal, V2019, P5236851, DOI 10.1155/2019/5236851
   Sajadimajd S, 2020, PHARMACOL RES, V151, DOI 10.1016/j.phrs.2019.104584
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Saleem Z, 2022, CURR PHARM DESIGN, V28, P1632, DOI 10.2174/1381612828666220705113514
   Salehi B, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20061305
   Sales NMR, 2014, J NUTR METAB, V2014, DOI 10.1155/2014/202759
   Sánchez B, 2012, FORENSIC SCI INT, V223, pE1, DOI 10.1016/j.forsciint.2012.07.010
   Sandhir R, 2014, NEUROMOL MED, V16, P106, DOI 10.1007/s12017-013-8261-y
   Sandoval-Acuña C, 2014, ARCH BIOCHEM BIOPHYS, V559, P75, DOI 10.1016/j.abb.2014.05.017
   Sarkhosh-Khorasani S, 2021, NUTR J, V20, DOI 10.1186/s12937-021-00686-5
   Scheepens A, 2010, GENES NUTR, V5, P75, DOI 10.1007/s12263-009-0148-z
   Sekirov I, 2010, PHYSIOL REV, V90, P859, DOI 10.1152/physrev.00045.2009
   Senaphan K, 2015, NUTRIENTS, V7, P6446, DOI 10.3390/nu7085283
   Shabbir U, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010206
   Shahwan M, 2022, INT J BIOL MACROMOL, V206, P567, DOI 10.1016/j.ijbiomac.2022.03.004
   Shanaida M, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.563436
   Shehzad A, 2010, ARCH PHARM, V343, P489, DOI 10.1002/ardp.200900319
   Singh G, 2014, EXPERT OPIN DRUG DEL, V11, P647, DOI 10.1517/17425247.2014.890588
   Singhal A, 2006, NUTR REV, V64, pS44, DOI 10.1301/nr.2006.may.S44-S49
   Sioumis N, 2006, FOOD CHEM, V94, P98, DOI 10.1016/j.foodchem.2004.10.059
   Siroma TK, 2022, FRONT NUTR, V8, DOI 10.3389/fnut.2021.781622
   Siti HN, 2015, VASC PHARMACOL, V71, P40, DOI 10.1016/j.vph.2015.03.005
   Siu FYK, 2018, INT J NANOMED, V13, P4133, DOI 10.2147/IJN.S164235
   Song XH, 2016, ONCOTARGET, V7, P65732, DOI 10.18632/oncotarget.11610
   Soory Mena, 2009, Infectious Disorders - Drug Targets, V9, P400
   Squillaro T, 2018, BIOCHEM PHARMACOL, V154, P303, DOI 10.1016/j.bcp.2018.05.016
   Stanek N, 2019, J CHROMATOGR A, V1598, P209, DOI 10.1016/j.chroma.2019.04.052
   Stechyshyn Iryna, 2019, Romanian Journal of Diabetes Nutrition and Metabolic Diseases, V26, P393, DOI 10.2478/rjdnmd-2019-0042
   Steinkellner H, 2001, MUTAT RES-FUND MOL M, V480, P285, DOI 10.1016/S0027-5107(01)00188-9
   Stepanic V, 2015, CURR TOP MED CHEM, V15, P496, DOI 10.2174/1568026615666150209123100
   Storz G, 1999, CURR OPIN MICROBIOL, V2, P188, DOI 10.1016/S1369-5274(99)80033-2
   Sun AJ, 2011, BRIT J PHARMACOL, V164, P2042, DOI 10.1111/j.1476-5381.2011.01518.x
   Teng H, 2019, CRIT REV FOOD SCI, V59, P2040, DOI 10.1080/10408398.2018.1437023
   Tian C, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/7398453
   Tie SS, 2022, J AGR FOOD CHEM, V70, P903, DOI 10.1021/acs.jafc.1c05012
   Tresserra-Rimbau A, 2014, NUTR METAB CARDIOVAS, V24, P639, DOI 10.1016/j.numecd.2013.12.014
   Tsao R, 2010, NUTRIENTS, V2, P1231, DOI 10.3390/nu2121231
   Tsuchiya H, 2000, PHYTOMEDICINE, V7, P161, DOI 10.1016/S0944-7113(00)80089-6
   Ullah R, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061195
   van Duynhoven J, 2011, P NATL ACAD SCI USA, V108, P4531, DOI 10.1073/pnas.1000098107
   Vivo-Sese I., 2007, Analysis of cosmetic products, P380
   Vuolo MM, 2019, BIOACTIVE COMPOUNDS: HEALTH BENEFITS AND POTENTIAL APPLICATIONS, P33, DOI 10.1016/B978-0-12-814774-0.00002-5
   Walker DM, 2011, NAT REV ENDOCRINOL, V7, P197, DOI 10.1038/nrendo.2010.215
   Wang ST, 2020, WORLD J GASTROENTERO, V26, P562, DOI 10.3748/wjg.v26.i6.562
   Wang SB, 2009, EUR J PHARMACOL, V615, P125, DOI 10.1016/j.ejphar.2009.04.061
   Wang ZY, 2021, J AGR FOOD CHEM, V69, P1441, DOI 10.1021/acs.jafc.0c08085
   Wei MJ, 2018, TOXICOL SCI, V162, P99, DOI 10.1093/toxsci/kfx230
   Wing RR, 2005, AM J CLIN NUTR, V82, p222S, DOI 10.1093/ajcn/82.1.222S
   Wright GD, 2007, CELL, V130, P781, DOI 10.1016/j.cell.2007.08.023
   Wu HT, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/3631565
   Xu YJ, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.875826
   Yadav M., 2020, ASIAN J BIOL LIFE SC, V9, P1, DOI [10.5530/ajbls.2020.9.1, DOI 10.5530/ajbls.2020.9.1]
   Yahfoufi N, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111618
   Yamagata K, 2021, MOLECULES, V26, DOI 10.3390/molecules26195863
   Yan YW, 2020, J IMMUNOL RES, V2020, DOI 10.1155/2020/9680508
   Yang CS, 2009, ARCH TOXICOL, V83, P11, DOI 10.1007/s00204-008-0372-0
   Yessenkyzy A, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051344
   Yuan L, 2016, BIOMED PHARMACOTHER, V81, P356, DOI 10.1016/j.biopha.2016.04.025
   Zamani-Garmsiri F, 2022, PHYTOTHER RES, V36, P415, DOI 10.1002/ptr.7329
   Zaulet M, 2017, EXP THER MED, V13, P821, DOI 10.3892/etm.2017.4066
   Zern TL, 2005, J NUTR, V135, P2291, DOI 10.1093/jn/135.10.2291
   Zhang H, 2016, CURR OPIN FOOD SCI, V8, P33, DOI 10.1016/j.cofs.2016.02.002
   Zhang JM, 2019, J FOOD BIOCHEM, V43, DOI 10.1111/jfbc.12796
   Zhang L, 2020, CRIT REV FOOD SCI, V60, P2083, DOI 10.1080/10408398.2019.1630358
   Zhang M, 2009, INT J CANCER, V124, P1404, DOI 10.1002/ijc.24047
   Zhang SY, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22116110
   Zhang WN, 2022, BIOTECHNOL LETT, V44, P387, DOI 10.1007/s10529-022-03234-1
   Zhou Y, 2021, MOLECULES, V26, DOI 10.3390/molecules26082320
   Zwierello W, 2020, CHEMOSPHERE, V240, DOI 10.1016/j.chemosphere.2019.124901
NR 267
TC 88
Z9 88
U1 8
U2 48
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD OCT
PY 2022
VL 27
IS 19
AR 6280
DI 10.3390/molecules27196280
PG 34
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 5G6HT
UT WOS:000867098600001
PM 36234817
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kozlowska, D
   Mysliwiec, H
   Flisiak, I
AF Kozlowska, Dorota
   Mysliwiec, Hanna
   Flisiak, Iwona
TI Inflammation and lipid metabolism as a strong background connecting
   psoriasis and liver diseases
SO PRZEGLAD DERMATOLOGICZNY
LA English
DT Review
DE metabolic syndrome; psoriasis; inflammation; lipids; non-alcoholic;
   fatty liver disease
ID FATTY LIVER; BILIARY-CIRRHOSIS; HEPATITIS; RISK; CERAMIDES; ARTHRITIS;
   PROFILE; NAFLD; IL-6
AB Psoriasis is not an isolated pathology of the skin and joints, but is also characterized by multiple extracutaneous systemic manifestations. Beside the co-occurrence of obesity, arterial hypertension, dyslipidemia, and type 2 diabetes mellitus, there is a strong correlation with many liver disturbances. The most common liver comorbid disease coexisting with psoriasis is non-alcoholic fatty liver disease, which is a hepatic manifestation of metabolic syndrome. Both diseases share the same molecular mechanisms: chronic systemic inflammation, oxidative stress, disturbances of lipid metabolism, immune pathways and secretions of bioactive molecules. Additionally, patients with psoriasis have an increased risk of developing autoimmune liver disease and also liver cancer in comparison to the heathy population. Moreover, drugs used in treatment of psoriasis and psoriatic arthritis augment the hepatotoxic effect on the liver. The study below presents the most recent data on the liver diseases and their pathogenesis in patients with psoriasis.
C1 [Kozlowska, Dorota; Mysliwiec, Hanna; Flisiak, Iwona] Med Univ Bialystok, Dept Dermatol & Venereol, Bialystok, Poland.
C3 Medical University of Bialystok
RP Kozlowska, D (corresponding author), Uniwersytet Med Bialymstoku, Klin Dermatol & Wenerol, Ul Zurawia 14, PL-15540 Bialystok, Poland.
EM dorota.kozlowska@umb.edu.pl
RI Kozłowska, Dorota/T-4060-2018; Flisiak, Iwona/R-5874-2018; Myśliwiec,
   Hanna/S-6326-2018
CR Abedini R, 2015, CLIN EXP DERMATOL, V40, P722, DOI 10.1111/ced.12672
   Balato N, 2015, WORLD J GASTROENTERO, V21, P6892, DOI 10.3748/wjg.v21.i22.6892
   Barak V, 2009, J AUTOIMMUN, V33, P178, DOI 10.1016/j.jaut.2009.09.010
   Baran A, 2017, LIPIDS, V52, P51, DOI 10.1007/s11745-016-4211-4
   Baran A, 2019, ARCH DERMATOL RES, V311, P389, DOI 10.1007/s00403-019-01917-w
   Baran A, 2017, PRZ DERMATOL, V104, P619, DOI 10.5114/dr.2017.71834
   Beretta-Piccoli BT, 2017, CLIN REV ALLERG IMMU, V53, P394, DOI 10.1007/s12016-017-8649-9
   Bergmann J, 2017, HEPATOLOGY, V65, P89, DOI 10.1002/hep.28874
   Blachier M, 2013, J HEPATOL, V58, P593, DOI 10.1016/j.jhep.2012.12.005
   Boehncke WH, 2015, LANCET, V386, P983, DOI 10.1016/S0140-6736(14)61909-7
   Bogdanos DP, 2017, CURR OPIN RHEUMATOL, V29, P369, DOI 10.1097/BOR.0000000000000394
   Borodzicz S, 2016, LIPIDS HEALTH DIS, V15, DOI 10.1186/s12944-016-0178-7
   Burfield L, 2013, J ROY COLL PHYS EDIN, V43, P334, DOI 10.4997/JRCPE.2013.414
   Byrne CD, 2015, J HEPATOL, V62, pS47, DOI 10.1016/j.jhep.2014.12.012
   Cacoub P, 2014, DIGEST LIVER DIS, V46, pS165, DOI 10.1016/j.dld.2014.10.005
   Campanati A, 2013, J GASTROENTEROL, V48, P839, DOI 10.1007/s00535-012-0678-9
   Candia R, 2015, J EUR ACAD DERMATOL, V29, P656, DOI 10.1111/jdv.12847
   Cantini F, 2014, INT J RHEUMATOL, V2014, DOI 10.1155/2014/926836
   Chaurasia B, 2015, TRENDS ENDOCRIN MET, V26, P538, DOI 10.1016/j.tem.2015.07.006
   Chehimi M, 2017, J CLIN MED, V6, DOI 10.3390/jcm6070068
   Czarnecka-Operacz M, 2014, POSTEP DERM ALERGOL, V31, P392, DOI 10.5114/pdia.2014.47121
   Desai A, 2019, WORLD J HEPATOL, V11, P1, DOI 10.4254/wjh.v11.i1.1
   Efe C, 2012, EUR J GASTROEN HEPAT, V24, P531, DOI 10.1097/MEG.0b013e328350f95b
   Fiore M, 2018, BIOMED RES INT, V2018, DOI 10.1155/2018/3140983
   Furuhashi M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027356
   Gajda AM, 2015, PROSTAG LEUKOTR ESS, V93, P9, DOI 10.1016/j.plefa.2014.10.001
   Ganzetti G, 2015, WORLD J HEPATOL, V7, P315, DOI 10.4254/wjh.v7.i3.315
   Ganzetti G, 2016, WORLD J CARDIOL, V8, P120, DOI 10.4330/wjc.v8.i2.120
   Gerdes S, 2020, J EUR ACAD DERMATOL, V34, P533, DOI 10.1111/jdv.16004
   Gisondi P, 2009, J HEPATOL, V51, P758, DOI 10.1016/j.jhep.2009.04.020
   Harada K, 2009, CLIN EXP IMMUNOL, V157, P261, DOI 10.1111/j.1365-2249.2009.03947.x
   Helliwell PS, 2008, J RHEUMATOL, V35, P472
   Herbert D, 2018, J INVEST DERMATOL, V138, P1999, DOI 10.1016/j.jid.2018.03.1522
   Hoofnagle JH, 2009, HEPATOLOGY, V49, pS156, DOI 10.1002/hep.22945
   Howel D, 2000, HEPATOLOGY, V31, P1055, DOI 10.1053/he.2000.7050
   Hsu S, 2012, ARCH DERMATOL, V148, P95, DOI 10.1001/archdermatol.2011.1410
   Hunter CA, 2015, NAT IMMUNOL, V16, P448, DOI 10.1038/ni.3153
   Imafuku S, 2013, J DERMATOL, V40, P813, DOI 10.1111/1346-8138.12240
   Imafuku S, 2013, J DERMATOL, V40, P428, DOI 10.1111/1346-8138.12112
   Janczyk W, 2013, BMC PEDIATR, V13, DOI 10.1186/1471-2431-13-85
   Kendall AC, 2017, BBA-BIOMEMBRANES, V1859, P1679, DOI 10.1016/j.bbamem.2017.03.016
   Kurek K, 2014, LIVER INT, V34, P1074, DOI 10.1111/liv.12331
   Madanagobalane S, 2012, AUSTRALAS J DERMATOL, V53, P190, DOI 10.1111/j.1440-0960.2012.00905.x
   Maldonado-Hernández J, 2017, CAN J GASTROENTEROL, V2017, DOI 10.1155/2017/3689375
   Mantovani A, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17020217
   Miele L, 2009, J HEPATOL, V51, P778, DOI 10.1016/j.jhep.2009.06.008
   Mikolasevic I, 2016, WORLD J GASTROENTERO, V22, P9488, DOI 10.3748/wjg.v22.i43.9488
   Miura H, 1999, INT J DERMATOL, V38, P310, DOI 10.1046/j.1365-4362.1999.00690.x
   Mysliwiec H, 2017, ARCH DERMATOL RES, V309, P371, DOI 10.1007/s00403-017-1748-x
   Mysliwiec H, 2017, ARCH DERMATOL RES, V309, P79, DOI 10.1007/s00403-016-1709-9
   Narayanasamy K, 2016, GASTROENTEROL REV, V11, P263, DOI 10.5114/pg.2015.53376
   Nast A, 2015, J EUR ACAD DERMATOL, V29, P2277, DOI 10.1111/jdv.13354
   Ng CY, 2018, J DERMATOL, V45, P309, DOI 10.1111/1346-8138.14079
   O'Mahoney LL, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0740-x
   Olveira A, 2019, REV ESP ENFERM DIG, V111, P314, DOI 10.17235/reed.2019.6263/2019
   Owczarczyk-Saczonek A, 2013, PRZ DERMATOL, V100, P125
   Parisi R, 2013, J INVEST DERMATOL, V133, P377, DOI 10.1038/jid.2012.339
   Pietrzak A, 2019, ARCH MED SCI, V15, P369, DOI 10.5114/aoms.2018.74021
   Pietrzak D, 2017, ARCH DERMATOL RES, V309, P679, DOI 10.1007/s00403-017-1775-7
   Prussick RB, 2018, BRIT J DERMATOL, V179, P16, DOI 10.1111/bjd.16239
   Reich A, 2018, PRZ DERMATOL, V105, P329, DOI 10.5114/dr.2018.77107
   Roberts KK, 2015, ALIMENT PHARM THER, V41, P293, DOI 10.1111/apt.13042
   Rodrigues S, 2015, WORLD J GASTROENTERO, V21, P7584, DOI 10.3748/wjg.v21.i24.7584
   Roll A, 2007, INDIAN J DERMATOL VE, V73, P133
   Sakkas LI, 2017, AUTOIMMUN REV, V16, P10, DOI 10.1016/j.autrev.2016.09.015
   Sales R, 2014, ACTA DERMATOVENER CR, V22, P169
   Stanley TL, 2011, J CLIN ENDOCR METAB, V96, pE146, DOI 10.1210/jc.2010-1170
   Tobon GJ, 2007, CLIN RHEUMATOL, V26, P578, DOI 10.1007/s10067-005-0169-y
   Treeprasertsuk S, 2013, WORLD J GASTROENTERO, V19, P1219, DOI 10.3748/wjg.v19.i8.1219
   Tula E, 2017, AUSTRALAS J DERMATOL, V58, P194, DOI 10.1111/ajd.12460
   van der Voort EAM, 2014, J AM ACAD DERMATOL, V70, P517, DOI 10.1016/j.jaad.2013.10.044
   Wasilewska N, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0855-9
   Weigle N, 2013, AM FAM PHYSICIAN, V87, P626
   Wenk KS, 2011, J EUR ACAD DERMATOL, V25, P383, DOI 10.1111/j.1468-3083.2010.03841.x
   Zhang Yuwen, 2014, Oncoscience, V1, P398
   Zhou L, 2017, ONCOL LETT, V14, P7817, DOI 10.3892/ol.2017.7217
NR 77
TC 1
Z9 1
U1 5
U2 9
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 0033-2526
EI 2084-9893
J9 PRZ DERMATOL
JI Prz. Dermatol.
PY 2020
VL 107
IS 3
BP 257
EP 272
DI 10.5114/dr.2020.97819
PG 16
WC Dermatology
WE Emerging Sources Citation Index (ESCI)
SC Dermatology
GA NJ2GT
UT WOS:000565864500006
OA gold
DA 2025-06-11
ER

PT J
AU Zhang, XY
   Jin, QX
   Jin, LH
AF Zhang, Xiaoyue
   Jin, Qiuxia
   Jin, Li Hua
TI High sugar diet disrupts gut homeostasis though JNK and STAT pathways in
   Drosophila
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE High sugar diet; Intestinal stem cell; Commensal bacteria; Intestinal
   homeostasis; Drosophila melanogaster
ID INTESTINAL STEM-CELLS; LIFE-SPAN; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; MELANOGASTER; IMMUNITY; OBESITY; MIDGUT;
   ACTIVATION
AB The incidence of diseases associated with a high sugar diet has increased in the past years, and numerous studies have focused on the effect of high sugar intake on obesity and metabolic syndrome. However, how a high sugar diet influences gut homeostasis is still poorly understood. In this study, we used Drosophila melanogaster as a model organism and supplemented a culture medium with 1 M sucrose to create a high sugar condition. Our results indicate that a high sugar diet promoted differentiation of intestinal stem cells through upregulation of the JNK pathway and downregulation of the JAK/STAT pathway. Moreover, the number of commensal bacteria decreased in the high sugar group. Our data suggests that the high caloric diet disrupts gut homeostasis and highlights Drosophila as an ideal model system to explore gastrointestinal disease. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Zhang, Xiaoyue; Jin, Qiuxia; Jin, Li Hua] Northeast Forestry Univ, Dept Genet, Coll Life Sci, Harbin, Peoples R China.
C3 Northeast Forestry University - China
RP Jin, LH (corresponding author), Northeast Forestry Univ, Dept Genet, Coll Life Sci, Harbin, Peoples R China.
EM lhjin2000@hotmail.com
FU National Natural Science Foundation of China [31270923]; Fundamental
   Research Funds for the Central Universities [2572016EAJ4]
FX We thank Rongwen Xi, Bruno Lemaitre, Jiwon Shim and Jose' Carlos
   Pastor-Pareja for the flies, the Bloomington and DGRC fly stock center
   and the TsingHua Fly Center for the fly stocks, the Developmental
   Studies Hybridoma Bank for providing the antibodies. This work was
   supported by grants from the National Natural Science Foundation of
   China [31270923] and the Fundamental Research Funds for the Central
   Universities [2572016EAJ4].
CR Ahn HM, 2012, DEV COMP IMMUNOL, V38, P466, DOI 10.1016/j.dci.2012.07.002
   Bae YS, 2010, TRENDS IMMUNOL, V31, P278, DOI 10.1016/j.it.2010.05.003
   Biteau B, 2008, CELL STEM CELL, V3, P442, DOI 10.1016/j.stem.2008.07.024
   Broderick NA, 2014, MBIO, V5, DOI 10.1128/mBio.01117-14
   Brummel T, 2004, P NATL ACAD SCI USA, V101, P12974, DOI 10.1073/pnas.0405207101
   Buchon N, 2009, CELL HOST MICROBE, V5, P200, DOI 10.1016/j.chom.2009.01.003
   Chakrabarti S, 2016, PLOS GENET, V12, DOI 10.1371/journal.pgen.1006089
   Chandler JA, 2014, PEERJ, V2, DOI 10.7717/peerj.474
   Chandler JA, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002272
   Dobson AJ, 2017, CELL REP, V18, P299, DOI 10.1016/j.celrep.2016.12.029
   Goulas S, 2012, CELL STEM CELL, V11, P529, DOI 10.1016/j.stem.2012.06.017
   Guo Z, 2016, CURR OPIN GENET DEV, V40, P81, DOI 10.1016/j.gde.2016.06.009
   Guo Z, 2015, SCIENCE, V350, DOI 10.1126/science.aab0988
   Hao YG, 2017, ELIFE, V6, DOI 10.7554/eLife.25094
   Jiang HQ, 2016, CELL MOL LIFE SCI, V73, P3337, DOI 10.1007/s00018-016-2235-9
   Jiang HQ, 2011, CELL STEM CELL, V8, P84, DOI 10.1016/j.stem.2010.11.026
   Jiang HQ, 2009, CELL, V137, P1343, DOI 10.1016/j.cell.2009.05.014
   Lee KA, 2013, CELL, V153, P797, DOI 10.1016/j.cell.2013.04.009
   Lin GN, 2010, J MOL CELL BIOL, V2, P37, DOI 10.1093/jmcb/mjp028
   Malik VS, 2010, DIABETES CARE, V33, P2477, DOI 10.2337/dc10-1079
   Micchelli CA, 2006, NATURE, V439, P475, DOI 10.1038/nature04371
   Mozaffarian D, 2011, NEW ENGL J MED, V364, P2392, DOI 10.1056/NEJMoa1014296
   Musselman LP, 2011, DIS MODEL MECH, V4, P842, DOI 10.1242/dmm.007948
   Na JB, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003175
   Nakagawa T, 2006, AM J PHYSIOL-RENAL, V290, pF625, DOI 10.1152/ajprenal.00140.2005
   Newell PD, 2014, APPL ENVIRON MICROB, V80, P788, DOI 10.1128/AEM.02742-13
   O'Brien LE, 2011, CELL, V147, P603, DOI 10.1016/j.cell.2011.08.048
   Ohlstein B, 2006, NATURE, V439, P470, DOI 10.1038/nature04333
   Ohlstein B, 2007, SCIENCE, V315, P988, DOI 10.1126/science.1136606
   Pastor-Pareja JC, 2013, ANNU REV GENET, V47, P51, DOI 10.1146/annurev-genet-110711-155414
   Reiter LT, 2001, GENOME RES, V11, P1114, DOI 10.1101/gr.169101
   Rovenko BM, 2015, J INSECT PHYSIOL, V79, P42, DOI 10.1016/j.jinsphys.2015.05.007
   Ryu JH, 2008, SCIENCE, V319, P777, DOI 10.1126/science.1149357
   Ryu JH, 2010, DEV COMP IMMUNOL, V34, P369, DOI 10.1016/j.dci.2009.11.010
   Samuelsson AM, 2008, HYPERTENSION, V51, P383, DOI 10.1161/HYPERTENSIONAHA.107.101477
   Sansone CL, 2015, CELL HOST MICROBE, V18, P571, DOI 10.1016/j.chom.2015.10.010
   Santabárbara-Ruiz P, 2015, PLOS GENET, V11, DOI 10.1371/journal.pgen.1005595
   Sharon G, 2010, P NATL ACAD SCI USA, V107, P20051, DOI 10.1073/pnas.1009906107
   Shim J, 2015, BMB REP, V48, P223, DOI 10.5483/BMBRep.2015.48.4.273
   Storelli G, 2011, CELL METAB, V14, P403, DOI 10.1016/j.cmet.2011.07.012
   Unckless RL, 2015, PLOS GENET, V11, DOI 10.1371/journal.pgen.1005030
   Wang CH, 2013, DEV BIOL, V378, P122, DOI 10.1016/j.ydbio.2013.03.020
   Wang MC, 2003, DEV CELL, V5, P811, DOI 10.1016/S1534-5807(03)00323-X
   Wong CNA, 2011, ENVIRON MICROBIOL, V13, P1889, DOI 10.1111/j.1462-2920.2011.02511.x
   Yang F, 2017, CELL MOL LIFE SCI, V74, P435, DOI 10.1007/s00018-016-2353-4
NR 45
TC 27
Z9 33
U1 2
U2 103
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD JUN 10
PY 2017
VL 487
IS 4
BP 910
EP 916
DI 10.1016/j.bbrc.2017.04.156
PG 7
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA EV6MO
UT WOS:000401883700023
PM 28476621
DA 2025-06-11
ER

PT J
AU Harskamp, RE
   Zeeman, GG
AF Harskamp, Ralf E.
   Zeeman, Gerda G.
TI Preeclampsia: At risk for remote cardiovascular disease
SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES
LA English
DT Article
DE preeclampsia; cardiovascular disease; hypertension; metabolic syndrome
ID ISCHEMIC-HEART-DISEASE; OXIDATIVE STRESS; WOMEN; PREGNANCY;
   HYPERTENSION; HISTORY; STROKE; LIPOPROTEIN(A)
AB Epidemiological data indicate that women with preeclampsia are more likely to develop cardiovascular disease (CVD) later in life. Population-based studies relate preeclampsia to an increased risk of later chronic hypertension (RR, 2.00 to 8.00) and cardiovascular morbidity/mortality (RR, 1.3 to 3.07), compared with normotensive pregnancy. Women who develop preeclampsia before 36 weeks of gestation or have multiple hypertensive pregnancies are at highest risk (RR, 3.4 to 8.12). The underlying mechanism for the remote effects of preeclampsia is complex and probably multifactorial. Many risk factors are shared by CVD and preeclampsia, including endothelial dysfunction, obesity, hypertension, hyperglycemia, insulin resistance, and dyslipidemia. Therefore, it has been proposed that the metabolic syndrome may be a possible underlying mechanism common to CVD and preeclampsia. Follow-up and counseling of women with a history of preeclampsia may offer a window of opportunity for prevention of future disease.
C1 Univ Texas, Hlth Sci Ctr, San Antonio, TX 78229 USA.
   Univ Groningen, Univ Med Ctr Groningen, Dept Obstet & Gynecol, Groningen, Netherlands.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio; University of Groningen
RP Harskamp, RE (corresponding author), Univ Texas, Hlth Sci Ctr, 4900 Med Dr,504, San Antonio, TX 78229 USA.
EM r.e.harskamp@gmail.com
RI Harskamp, Ralf/A-9816-2009
CR ADAMS EM, 1961, LANCET, V2, P1373
   Agatisa PK, 2004, AM J PHYSIOL-HEART C, V286, pH1389, DOI 10.1152/ajpheart.00298.2003
   Barden AE, 1999, J HYPERTENS, V17, P1307, DOI 10.1097/00004872-199917090-00011
   Bayhan GH, 2005, GYNECOL ENDOCRINOL, V21, P1, DOI 10.1080/09513590500097382
   BROSENS IA, 1977, CLIN OBSTET GYNAECOL, V4, P573
   Brown DW, 2006, STROKE, V37, P1055, DOI 10.1161/01.STR.0000206284.96739.ee
   CHESLEY LC, 1976, AM J OBSTET GYNECOL, V124, P446, DOI 10.1016/0002-9378(76)90168-X
   CUNNINGHAM FG, 1992, NEW ENGL J MED, V326, P927
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Funato H, 2000, MOL CELL NEUROSCI, V16, P206, DOI 10.1006/mcne.2000.0870
   Granger JP, 2002, MICROCIRCULATION, V9, P147, DOI 10.1038/sj.mn.7800137
   Hannaford P, 1997, HEART, V77, P154, DOI 10.1136/hrt.77.2.154
   He S, 1999, THROMB HAEMOSTASIS, V81, P538
   Hubel CA, 1999, P SOC EXP BIOL MED, V222, P222, DOI 10.1046/j.1525-1373.1999.d01-139.x
   Irgens HU, 2001, BRIT MED J, V323, P1213, DOI 10.1136/bmj.323.7323.1213
   Jonsdottir LS, 1995, ACTA OBSTET GYN SCAN, V74, P772
   Kestenbaum B, 2003, AM J KIDNEY DIS, V42, P982, DOI 10.1016/j.ajkd.2003.07.001
   Laivuori H, 1996, J CLIN ENDOCR METAB, V81, P2908, DOI 10.1210/jc.81.8.2908
   Ness RB, 2003, OBSTET GYNECOL, V102, P1366, DOI 10.1016/j.obstetgynecol.2003.08.011
   Ray JG, 2005, LANCET, V366, P1797, DOI 10.1016/S0140-6736(05)67726-4
   Redman CWG, 1999, AM J OBSTET GYNECOL, V180, P499, DOI 10.1016/S0002-9378(99)70239-5
   Roberts JM, 1999, LANCET, V354, P788, DOI 10.1016/S0140-6736(99)80002-6
   ROBERTS JM, 1993, LANCET, V341, P1447, DOI 10.1016/0140-6736(93)90889-O
   SATTAR N, 2003, HYPERTENSION, V12, P12
   SIBAI BM, 1991, AM J OBSTET GYNECOL, V165, P1408
   SIKKEMA JM, 2001, J SOC GYNECOL INVEST, V8, P580
   Smith GCS, 2001, LANCET, V357, P2002, DOI 10.1016/S0140-6736(00)05112-6
   Smith GD, 2000, LANCET, V356, P2066, DOI 10.1016/S0140-6736(00)03406-1
   Solomon CG, 2001, HYPERTENSION, V37, P232, DOI 10.1161/01.HYP.37.2.232
   van Pampus MG, 1999, THROMB HAEMOSTASIS, V82, P10
   Wikström AK, 2005, BJOG-INT J OBSTET GY, V112, P1486, DOI 10.1111/j.1471-0528.2005.00733.x
   Williams D, 2003, CURR OPIN OBSTET GYN, V15, P465, DOI 10.1097/00001703-200312000-00002
   Wilson BJ, 2003, BRIT MED J, V326, P845, DOI 10.1136/bmj.326.7394.845
   Wolf M, 2004, J CLIN ENDOCR METAB, V89, P6239, DOI 10.1210/jc.2004-0548
NR 34
TC 132
Z9 144
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9629
EI 1538-2990
J9 AM J MED SCI
JI Am. J. Med. Sci.
PD OCT
PY 2007
VL 334
IS 4
BP 291
EP 295
DI 10.1097/MAJ.0b013e3180a6f094
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 222BO
UT WOS:000250271300011
PM 18030186
DA 2025-06-11
ER

PT J
AU Neri-Numa, IA
   Cazarin, CBB
   Ruiz, ALTG
   Paulino, BN
   Molina, G
   Pastore, GM
AF Neri-Numa, Iramaia Angelica
   Betim Cazarin, Cinthia Bau
   Tasca Gois Ruiz, Ana Lucia
   Paulino, Bruno Nicolau
   Molina, Gustavo
   Pastore, Glaucia Maria
TI Targeting flavonoids on modulation of metabolic syndrome
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Review
DE Obesity; Insulin resistance; Type 2 diabetes; Cardiovascular diseases;
   Microbiota; Nutrigenetic
ID HIGH-FAT DIET; GUT MICROBIOTA; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   BLOOD-PRESSURE; DOUBLE-BLIND; GREEN TEA; INTESTINAL MICROBIOTA;
   OVERWEIGHT SUBJECTS; INSULIN-RESISTANCE
AB Metabolic Syndrome (MetS) is a complex condition associated with cardiovascular risk factors and diabetes. The weight gain, especially the accumulation of central adipose tissue, may be the first leading cause of the MetS. It is important to highlight that the lifestyle choices considered as modifiable risk factors contribute to the increase in the incidence of the MetS in the population, such as sedentarism and food intake. There is evidence in the literature concerning the benefits associated with the Mediterranean diet, which is rich in polyphenols. Therefore, the flavonoids are a class of non-nutrient that can be extensively studied mainly to elucidate the mechanisms related to the action of these compounds in the modulation of the microbiota, DNA methylation and health improvement. Thus, this review summarized evidence linking flavonoid intake to obesity, insulin resistance, T2DM and cardiovascular diseases.
C1 [Neri-Numa, Iramaia Angelica; Pastore, Glaucia Maria] Univ Estadual Campinas, Fac Food Engn, Dept Food Sci, Lab Bioflavours & Bioact Cpds,UNICAMP, BR-13083862 Campinas, SP, Brazil.
   [Betim Cazarin, Cinthia Bau] Univ Estadual Campinas, Dept Food & Nutr, Nutr & Metab Lab, UNICAMP, BR-13083862 Campinas, SP, Brazil.
   [Tasca Gois Ruiz, Ana Lucia] Univ Estadual Campinas, Fac Pharmaceut Sci, UNICAMP, BR-13083871 Campinas, SP, Brazil.
   [Paulino, Bruno Nicolau] Fed Univ Amazonas UFAM, Fac Pharmaceut Sci, BR-69080900 Manaus, Amazonas, Brazil.
   [Molina, Gustavo] Fed Univ Jequitinhonha & Mucuri Valleys UFVJM, Inst Sci & Technol, Diamantina, MG, Brazil.
C3 Universidade Estadual de Campinas; Universidade Estadual de Campinas;
   Universidade Estadual de Campinas; Universidade Federal de Amazonas;
   Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM)
RP Neri-Numa, IA (corresponding author), Univ Estadual Campinas, Fac Food Engn, Dept Food Sci, Lab Bioflavours & Bioact Cpds, Monteiro Lobato St 80, BR-13083862 Campinas, SP, Brazil.
EM iramaia@unicamp.br
RI Paulino, Bruno/ABC-8664-2021; Numa, Iramaia/T-7472-2019; Molina,
   Gustavo/ABF-1526-2020; Ruiz, Ana Lucia/C-2249-2012; Bau Betim Cazarin,
   Cinthia/I-8837-2014
OI Bau Betim Cazarin, Cinthia/0000-0002-9849-2546; Tasca Gois Ruiz, Ana
   Lucia/0000-0002-0844-8702
FU National Council for Scientific and Technological Development (CNPq)
   [406820/2018-0]; Sao Paulo Research Foundation (FAPESP) [2015/50333-1];
   Minas Gerais Research Foundation (FAPEMIG) [APQ-01056-17]; Coordination
   for the Improvement of Higher Education Personnel (CAPES) [001]
FX The authors thank the National Council for Scientific and Technological
   Development (CNPq, grant numbers 406820/2018-0), Sao Paulo Research
   Foundation (FAPESP, grant number 2015/50333-1), Minas Gerais Research
   Foundation (FAPEMIG, grant number APQ-01056-17), and Coordination for
   the Improvement of Higher Education Personnel (CAPES, Finance Code 001)
   for their financial support.
CR Abdellatif AM, 2019, J DIABETES, V11, P632, DOI 10.1111/1753-0407.12915
   Aboonabi A, 2020, CHEM-BIOL INTERACT, V317, DOI 10.1016/j.cbi.2020.108940
   Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Ahmed A, 2020, J NUTR SCI, V9, DOI 10.1017/jns.2020.7
   Ahn J, 2008, BIOCHEM BIOPH RES CO, V373, P545, DOI 10.1016/j.bbrc.2008.06.077
   Akhlaghi M, 2018, NUTR METAB CARDIOVAS, V28, P675, DOI 10.1016/j.numecd.2018.04.001
   Akhlaghi M, 2020, NUTR RES REV, V33, P1, DOI 10.1017/S0954422419000155
   Akhlaghi M, 2017, ADV NUTR, V8, P705, DOI 10.3945/an.117.015370
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alkutbe R, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030766
   Alnajjar M, 2020, J FUNCT FOODS, V64, DOI 10.1016/j.jff.2019.103597
   Alperet DJ, 2017, AM J CLIN NUTR, V105, P736, DOI 10.3945/ajcn.116.147090
   Alvarado J, 2016, PANMINERVA MED, V58
   Alvarado JL, 2016, BIOMED RES INT, V2016, DOI 10.1155/2016/9070537
   Alvarado-Díaz CS, 2019, J FOOD BIOCHEM, V43, DOI 10.1111/jfbc.12896
   Andersson C, 2019, NAT REV CARDIOL, V16, P687, DOI 10.1038/s41569-019-0202-5
   Angelino D, 2017, FOOD FUNCT, V8, P2368, DOI [10.1039/c7fo00574a, 10.1039/C7FO00574A]
   [Anonymous], 2019, PHARMACEUTICALS-BASE, DOI DOI 10.3390/ph12040152
   [Anonymous], [No title captured]
   [Anonymous], 2019, MOL BASEL SWITZERLAN, DOI DOI 10.3390/MOLECULES24152809
   Ansarimoghaddam A, 2018, DIABETES METAB SYND, V12, P195, DOI 10.1016/j.dsx.2017.11.004
   Anunciaçao PC, 2018, EUR J NUTR, V57, P251, DOI 10.1007/s00394-016-1314-x
   Arumugam M, 2011, NATURE, V473, P174, DOI 10.1038/nature09944
   Asgary S, 2016, J SCI FOOD AGR, V96, P764, DOI 10.1002/jsfa.7144
   Aviram M., 2004, INT C SERIES, V1262, P320, DOI [10.1016/S0531-5131(03)01453-5, DOI 10.1016/S0531-5131(03)01453-5]
   Bai YF, 2019, NUTR DIABETES, V9, DOI 10.1038/s41387-019-0097-6
   Banihani SA, 2020, FOOD SCI NUTR, V8, P567, DOI 10.1002/fsn3.1344
   Barik SK, 2020, J NUTR BIOCHEM, V78, DOI 10.1016/j.jnutbio.2019.108325
   Bell L, 2017, FOOD FUNCT, V8, P3104, DOI [10.1039/c7fo00724h, 10.1039/c7fO00724h]
   Belzer C, 2012, ISME J, V6, P1449, DOI 10.1038/ismej.2012.6
   Berbers RM, 2017, TRENDS IMMUNOL, V38, P206, DOI 10.1016/j.it.2016.11.008
   Bhaswant M, 2019, J FUNCT FOODS, V56, P119, DOI 10.1016/j.jff.2019.03.011
   Bidel Z, 2018, CLIN NUTR ESPEN, V27, P86, DOI 10.1016/j.clnesp.2018.06.004
   Bondonno NP, 2020, CLIN NUTR, V39, P3821, DOI 10.1016/j.clnu.2020.04.025
   Bondonno NP, 2019, NAT COMMUN, V10, DOI [10.1038/s41467-019-11622-X, 10.1038/s41467-019-11622-x]
   Breuninger TA, 2018, J NUTR SCI, V7, DOI 10.1017/jns.2018.25
   Buraczynska M, 2014, MOL BIOL REP, V41, P4063, DOI 10.1007/s11033-014-3275-6
   Burke AC, 2018, J LIPID RES, V59, P1714, DOI 10.1194/jlr.M087387
   Butacnum A, 2017, ASIA PAC J CLIN NUTR, V26, P59, DOI 10.6133/apjcn.112015.08
   Cardona F, 2013, J NUTR BIOCHEM, V24, P1415, DOI 10.1016/j.jnutbio.2013.05.001
   Espín JC, 2017, BIOCHEM PHARMACOL, V139, P82, DOI 10.1016/j.bcp.2017.04.033
   Cassidy A, 2015, AM J CLIN NUTR, V102, P172, DOI 10.3945/ajcn.115.108555
   Castro-Acosta ML, 2017, J NUTR BIOCHEM, V49, P53, DOI 10.1016/j.jnutbio.2017.07.013
   Castro-Acosta ML, 2016, J NUTR BIOCHEM, V38, P154, DOI 10.1016/j.jnutbio.2016.09.002
   Chen JG, 2020, INT J BIOL MACROMOL, V143, P696, DOI 10.1016/j.ijbiomac.2019.09.091
   Chen TY, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201700111
   Chen ZQ, 2019, J FUNCT FOODS, V52, P663, DOI 10.1016/j.jff.2018.11.049
   Chen ZQ, 2018, FOOD FUNCT, V9, P426, DOI [10.1039/c7fo00983f, 10.1039/C7FO00983F]
   Chew B, 2019, EUR J NUTR, V58, P1223, DOI 10.1007/s00394-018-1643-z
   Chistiakov DA, 2017, ATHEROSCLEROSIS, V263, P361, DOI 10.1016/j.atherosclerosis.2017.06.017
   Choi KH, 2017, ENVIRON TOXICOL PHAR, V54, P1, DOI 10.1016/j.etap.2017.06.007
   Chowdhury MZI, 2018, BMC PUBLIC HEALTH, V18, DOI 10.1186/s12889-018-5209-z
   Chusak C, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030782
   Cicero AFG, 2019, PHYTOTHER RES, V33, P2094, DOI 10.1002/ptr.6402
   Clarke SF, 2012, GUT MICROBES, V3, P186, DOI 10.4161/gmic.20168
   Coe S, 2016, NUTR RES, V36, P193, DOI 10.1016/j.nutres.2015.10.007
   Crovesy L, 2020, EUR J CLIN NUTR, V74, P1251, DOI 10.1038/s41430-020-0607-6
   D'Archivio M, 2010, INT J MOL SCI, V11, P1321, DOI 10.3390/ijms11041321
   D'Innocenzo S, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061306
   D'Oria R, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/5732956
   Daiber A, 2020, FREE RADICAL BIO MED, V157, P15, DOI 10.1016/j.freeradbiomed.2020.02.026
   Daiber A, 2017, BRIT J PHARMACOL, V174, P1591, DOI 10.1111/bph.13517
   Daiber A, 2017, BRIT J PHARMACOL, V174, P1670, DOI 10.1111/bph.13403
   de Souza MDC, 2018, EUR J VASC ENDOVASC, V55, P694, DOI 10.1016/j.ejvs.2018.02.009
   Di Meo S, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/1245049
   Ding L, 2010, J NUTR BIOCHEM, V21, P941, DOI 10.1016/j.jnutbio.2009.07.009
   Donado-Pestana CM, 2018, CURR OPIN FOOD SCI, V19, P42, DOI 10.1016/j.cofs.2018.01.001
   Donaldson GP, 2016, NAT REV MICROBIOL, V14, P20, DOI 10.1038/nrmicro3552
   Duda-Chodak A, 2015, EUR J NUTR, V54, P325, DOI 10.1007/s00394-015-0852-y
   Duffy SJ, 2001, CIRCULATION, V104, P151, DOI 10.1161/01.CIR.104.2.151
   Durazzo A, 2020, FOODS, V9, DOI 10.3390/foods9030370
   Durazzo A, 2019, PHYTOTHER RES, V33, P2221, DOI 10.1002/ptr.6419
   Egert S, 2009, BRIT J NUTR, V102, P1065, DOI 10.1017/S0007114509359127
   el Bilbeisi AH, 2017, ETHIOP J HEALTH SCI, V27, P77, DOI 10.4314/ejhs.v27i1.10
   Escobedo J, 2009, CARDIOVASC DIABETOL, V8, DOI 10.1186/1475-2840-8-52
   Corrêa TAF, 2019, FRONT NUTR, V6, DOI 10.3389/fnut.2019.00188
   Faria A, 2014, J AGR FOOD CHEM, V62, P6898, DOI 10.1021/jf501808a
   Federation D, 2019, IDF Diabetes Atlas, V9
   Feliciano RP, 2015, CURR OPIN FOOD SCI, V2, P92, DOI 10.1016/j.cofs.2015.02.006
   Fernández-Bergés D, 2012, REV ESP CARDIOL, V65, P241, DOI [10.1016/j.recesp.2011.10.015, 10.1016/j.rec.2011.10.017]
   Fraga CG, 2019, FOOD FUNCT, V10, P514, DOI [10.1039/c8fo01997e, 10.1039/C8FO01997E]
   Fuentes J, 2020, FOOD CHEM, V314, DOI 10.1016/j.foodchem.2020.126166
   Fusi F, 2020, PHARMACOL RES, V152, DOI 10.1016/j.phrs.2019.104625
   Fusi F, 2017, EUR J PHARMACOL, V796, P158, DOI 10.1016/j.ejphar.2016.12.033
   Gebicka L, 2020, J INORG BIOCHEM, V208, DOI 10.1016/j.jinorgbio.2020.111095
   Gerken T, 2007, SCIENCE, V318, P1469, DOI 10.1126/science.1151710
   Girbovan A, 2017, MED MICROBIOL IMMUN, V206, P83, DOI 10.1007/s00430-017-0496-z
   González-Sarrías A, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201800160
   Górniak I, 2019, PHYTOCHEM REV, V18, P241, DOI 10.1007/s11101-018-9591-z
   Gowd V, 2019, TRENDS FOOD SCI TECH, V93, P81, DOI 10.1016/j.tifs.2019.09.005
   Guglielmetti S, 2020, BMC GERIATR, V20, DOI 10.1186/s12877-020-1472-9
   Hämäläinen M, 2007, MEDIAT INFLAMM, V2007, DOI 10.1155/2007/45673
   Hasler CM, 2002, J NUTR, V132, P3772, DOI 10.1093/jn/132.12.3772
   Haupt A, 2008, OBESITY, V16, P1969, DOI 10.1038/oby.2008.283
   Hossain MK, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17040569
   Hurrle S, 2017, BIOMED J, V40, P257, DOI 10.1016/j.bj.2017.06.007
   Hussain T, 2020, PHARMACOL RES, V152, DOI 10.1016/j.phrs.2020.104629
   Iino C, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020433
   Ikewuchi J. C., 2014, Biomedicine & Preventive Nutrition, V4, P257
   Johnson SA, 2020, J MED FOOD, V23, P1238
   Kaduka LU, 2012, DIABETES CARE, V35, P887, DOI 10.2337/dc11-0537
   Kelly TN, 2010, CIRC-CARDIOVASC GENE, V3, P539, DOI 10.1161/CIRCGENETICS.110.940635
   Kianbakht S, 2019, COMPLEMENT THER MED, V44, P296, DOI 10.1016/j.ctim.2019.05.010
   Kim CJ, 2015, INT J NURS PRACT, V21, P175, DOI 10.1111/ijn.12258
   Koch W, 2019, NUTRIENTS, V11, DOI 10.3390/nu11051039
   Koliada A, 2017, BMC MICROBIOL, V17, DOI 10.1186/s12866-017-1027-1
   Koppel N, 2017, SCIENCE, V356, DOI 10.1126/science.aag2770
   Lavefve L, 2020, FOOD FUNCT, V11, P45, DOI [10.1039/c9fo01634a, 10.1039/C9FO01634A]
   Lavelle A, 2020, NAT REV GASTRO HEPAT, V17, P223, DOI 10.1038/s41575-019-0258-z
   Lee YH, 2008, OBESITY, V16, P1493, DOI 10.1038/oby.2008.267
   Lenquiste SA, 2019, FOOD RES INT, V120, P880, DOI 10.1016/j.foodres.2018.11.053
   Li R, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-2870-y
   Li XJ, 2020, BOSNIAN J BASIC MED, V20, P31, DOI 10.17305/bjbms.2019.4321
   Gutiérrez-Solis AL, 2018, METAB SYNDR RELAT D, V16, P395, DOI 10.1089/met.2017.0157
   Lin KH, 2019, J FUNCT FOODS, V52, P212, DOI 10.1016/j.jff.2018.10.038
   Lin SL, 2019, FOOD NUTR RES, V63, DOI 10.29219/fnr.v63.1518
   Lotito SB, 2006, FREE RADICAL BIO MED, V41, P1727, DOI 10.1016/j.freeradbiomed.2006.04.033
   Luca SV, 2020, CRIT REV FOOD SCI, V60, P626, DOI 10.1080/10408398.2018.1546669
   Maleki SJ, 2019, FOOD CHEM, V299, DOI 10.1016/j.foodchem.2019.125124
   Marín L, 2015, BIOMED RES INT-UK, V2015, DOI 10.1155/2015/905215
   Marinou K, 2010, INT J CARDIOL, V138, P3, DOI 10.1016/j.ijcard.2009.03.135
   Marranzano M, 2018, INT J FOOD SCI NUTR, V69, P1020, DOI 10.1080/09637486.2018.1452900
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   Millar CL, 2017, ADV NUTR, V8, P226, DOI 10.3945/an.116.014050
   Hoang MH, 2015, J NUTR BIOCHEM, V26, P868, DOI 10.1016/j.jnutbio.2015.03.005
   Moorthy M, 2020, TRENDS FOOD SCI TECH, V99, P634, DOI 10.1016/j.tifs.2020.03.036
   Müller MJ, 2017, EUR J CLIN NUTR, V71, P1256, DOI 10.1038/ejcn.2017.155
   Murota K, 2018, BIOSCI BIOTECH BIOCH, V82, P600, DOI 10.1080/09168451.2018.1444467
   Nolan Paul B, 2017, Prev Med Rep, V7, P211, DOI 10.1016/j.pmedr.2017.07.004
   Novotny JA, 2015, J NUTR, V145, P1185, DOI 10.3945/jn.114.203190
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Ochiai A, 2016, SCI REP-UK, V6, DOI 10.1038/srep24940
   Oguoma VM, 2015, PUBLIC HEALTH, V129, P413, DOI 10.1016/j.puhe.2015.01.017
   Olsson M, 2011, METABOLISM, V60, P114, DOI 10.1016/j.metabol.2010.05.011
   Orces CH, 2017, DIABETES METAB SYND, V11, pS555, DOI 10.1016/j.dsx.2017.04.004
   Owona BA, 2020, INT IMMUNOPHARMACOL, V84, DOI 10.1016/j.intimp.2020.106498
   Ozdal T, 2016, NUTRIENTS, V8, DOI 10.3390/nu8020078
   Pan MH, 2019, FOOD FUNCT, V10, P7667, DOI 10.1039/c9fo02235j
   Pan MH, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201601104
   Panahi G, 2018, ARCH PHYSIOL BIOCHEM, V124, P468, DOI 10.1080/13813455.2018.1427764
   Pearce LR, 2013, CELL, V155, P765, DOI 10.1016/j.cell.2013.09.058
   Pei RS, 2020, CURR OPIN BIOTECH, V61, P153, DOI 10.1016/j.copbio.2019.12.018
   Perez-Vizcaino F, 2018, ARCH BIOCHEM BIOPHYS, V646, P107, DOI 10.1016/j.abb.2018.03.022
   Poprac P, 2017, TRENDS PHARMACOL SCI, V38, P592, DOI 10.1016/j.tips.2017.04.005
   Procházková D, 2011, FITOTERAPIA, V82, P513, DOI 10.1016/j.fitote.2011.01.018
   Raposo L, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4471-9
   Rieder R, 2017, BRAIN BEHAV IMMUN, V66, P9, DOI 10.1016/j.bbi.2017.01.016
   Riediger ND, 2011, CAN MED ASSOC J, V183, pE1127, DOI 10.1503/cmaj.110070
   Rinninella E, 2019, MICROORGANISMS, V7, DOI 10.3390/microorganisms7010014
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Rowland I, 2018, EUR J NUTR, V57, P1, DOI 10.1007/s00394-017-1445-8
   Ruderman N. B., 2016, ENDOCRINOLOGY ADULT, V1, DOI 10.1016/B978-0-323-18907-1.00043-3
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Scheithauer TPM, 2016, MOL METAB, V5, P759, DOI 10.1016/j.molmet.2016.06.002
   Scholz EP, 2010, CARDIOVASC THER, V28, pe46, DOI 10.1111/j.1755-5922.2010.00212.x
   Scuteri A, 2015, EUR J PREV CARDIOL, V22, P486, DOI 10.1177/2047487314525529
   Serban MC, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.115.002713
   Serra D, 2018, TRENDS FOOD SCI TECH, V78, P224, DOI 10.1016/j.tifs.2018.06.007
   Shahidi F., 2018, J. Food Bioactives, V4, P11, DOI [DOI 10.31665/JFB.2018.4162, 10.31665/jfb.2018, DOI 10.31665/JFB.2018]
   Shi J, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00703
   Shin NR, 2015, TRENDS BIOTECHNOL, V33, P496, DOI 10.1016/j.tibtech.2015.06.011
   Sing N., 2018, J HEART STROKE, V3, P1044
   Singh AK, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092216
   Spahis S, 2017, ANTIOXID REDOX SIGN, V26, P445, DOI 10.1089/ars.2016.6756
   Stone NJ, 2005, AM J CARDIOL, V96, p53E, DOI 10.1016/j.amjcard.2005.06.006
   Suarez-Sanchez F., 2019, DIABETES TXB, P127, DOI [10.1007/978-3-030-11815-0_10, DOI 10.1007/978-3-030-11815-0_10]
   Subramani SK, 2019, DIABETES METAB SYND, V13, P816, DOI 10.1016/j.dsx.2018.12.003
   Takahashi H., 2015, NUTR INTERVENTION ME, P33, DOI [10.1201/b19099-5, DOI 10.1201/B19099-5]
   Tao J, 2020, CRIT REV FOOD SCI, V60, P1025, DOI 10.1080/10408398.2018.1555789
   Terao J, 2017, BIOCHEM PHARMACOL, V139, P15, DOI 10.1016/j.bcp.2017.03.021
   Testai L, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/4650207
   Thilakarathna SH, 2013, NUTRIENTS, V5, P3367, DOI 10.3390/nu5093367
   Tomás-Barberán FA, 2019, ANNU REV FOOD SCI T, V10, P221, DOI 10.1146/annurev-food-032818-121615
   Tsuda T, 2003, J NUTR, V133, P2125, DOI 10.1093/jn/133.7.2125
   Vidigal FD, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-1198
   Vimaleswaran KS, 2020, P NUTR SOC, V79, P194, DOI 10.1017/S0029665119001186
   Vita JA, 2005, AM J CLIN NUTR, V81, p292S, DOI 10.1093/ajcn/81.1.292S
   Vona R, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8267234
   Vugic L, 2020, J FUNCT FOODS, V64, DOI 10.1016/j.jff.2019.103596
   Wang H, 2020, MOL NUTR FOOD RES, V64, DOI 10.1002/mnfr.201900876
   Wang LC, 2018, J FOOD DRUG ANAL, V26, P973, DOI 10.1016/j.jfda.2017.11.009
   Wang S, 2014, J NUTR BIOCHEM, V25, P1, DOI 10.1016/j.jnutbio.2013.09.001
   Wang Y, 2007, INT J OBESITY, V31, P177, DOI 10.1038/sj.ijo.0803354
   Wang ZN, 2011, NATURE, V472, P57, DOI 10.1038/nature09922
   Whaley-Connell A, 2011, REV CARDIOVASC MED, V12, P21, DOI 10.3909/ricm0555
   WHO-World Health Organization, 2007, PREV CARD DIS GUID A, V364, DOI [10.1093/innovait/inr119, DOI 10.1093/INNOVAIT/INR119]
   World Health Organization, 1999, WHONCDNCS992
   Wu WQ, 2020, ENGINEERING-PRC, V6, P415, DOI 10.1016/j.eng.2019.07.026
   Xiao JB, 2017, CRIT REV FOOD SCI, V57, P1874, DOI 10.1080/10408398.2015.1032400
   Xu JL, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201801307
   Yamagata K, 2020, J CARDIOVASC PHARM, V75, P1, DOI 10.1097/FJC.0000000000000757
   Yang B, 2018, TRENDS FOOD SCI TECH, V79, P116, DOI 10.1016/j.tifs.2018.07.006
   Yang T, 2019, CRIT REV TOXICOL, V49, P445, DOI 10.1080/10408444.2019.1635987
   YOKOZAWA T, 1995, BIOSCI BIOTECH BIOCH, V59, P2134, DOI 10.1271/bbb.59.2134
   Zamponi GW, 2015, PHARMACOL REV, V67, P821, DOI 10.1124/pr.114.009654
   Zeng M, 2016, MOL NUTR FOOD RES, V60, P1006, DOI 10.1002/mnfr.201500692
   Zhang L, 2019, DRUG DEVELOP RES, V80, P294, DOI 10.1002/ddr.21495
   Zhao L, 2017, FOOD FUNCT, V8, P4644, DOI [10.1039/c7fo01383c, 10.1039/C7FO01383C]
NR 199
TC 23
Z9 23
U1 0
U2 20
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD OCT
PY 2020
VL 73
AR 104132
DI 10.1016/j.jff.2020.104132
PG 18
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA OC9UN
UT WOS:000579501700050
OA gold
DA 2025-06-11
ER

PT J
AU Keenan, RT
   Pilinger, MH
AF Keenan, Robert T.
   Pilinger, Michael H.
TI FEBUXOSTAT: A NEW AGENT FOR LOWERING SERUM URATE
SO DRUGS OF TODAY
LA English
DT Article
ID PURINE SELECTIVE INHIBITOR; XANTHINE-OXIDASE INHIBITOR; URIC-ACID;
   METABOLIC SYNDROME; OXIDATIVE STRESS; NATIONAL-HEALTH; BLOOD-PRESSURE;
   CHRONIC GOUT; LONG-TERM; ALLOPURINOL
AB The prevalence of gout has been increasing in epidemic proportions over the last several decades. Hyperuricemia has been shown to be associated with metabolic syndrome and to be an independent risk factor for cardiovascular disease. Associations between hyperuricemia, obesity and aging have provided an impetus in recent years to develop alternative methods of treating hyperuricemia and gout. Febuxostat is a new non-purine xanthine oxidase inhibitor indicated for chronic gout. Febuxostat has been shown to quickly and effectively lower serum urate levels in patients with chronic gout. This manuscript will review febuxostat, its pharmacokinetics and pharmacodynamics, efficacy and adverse events and use in patients with comorbid conditions. The review will also summarize the phase Ill trials leading up to the drug's approval by both the European Commission in 2008 and the U.S. FDA in 2009. Possible implications the medication may have in the future on gout and hyperuricemia will also be discussed.
C1 [Keenan, Robert T.; Pilinger, Michael H.] NYU Hosp Joint Dis, Div Rheumatol, New York Harbor Vet Hlth Care Syst, New York, NY 10003 USA.
C3 New York University
RP Keenan, RT (corresponding author), NYU Hosp Joint Dis, Div Rheumatol, New York Harbor Vet Hlth Care Syst, 301 E 17th St,Room 1410,New York Campus, New York, NY 10003 USA.
EM Robert.keenan@nyumc.org
RI Keenan, Robert/JFT-0366-2023
OI Pillinger, Michael/0000-0003-3168-1542
CR Becker MA, 2007, ANN RHEUM DIS, V66, P231
   Becker MA, 2007, ANN RHEUM DIS, V66, P230
   Becker MA, 2004, NUCLEOS NUCLEOT NUCL, V23, P1111, DOI 10.1081/NCN-200027372
   Becker MA, 2004, ARTHRITIS RHEUM, V50, pS336
   Becker MA, 2005, NEW ENGL J MED, V353, P2450, DOI 10.1056/NEJMoa050373
   Becker MA, 2005, ARTHRITIS RHEUM, V52, P916, DOI 10.1002/art.20935
   BINDOLI A, 1985, PHARMACOL RES COMMUN, V17, P831, DOI 10.1016/0031-6989(85)90041-4
   Bruce SP, 2006, ANN PHARMACOTHER, V40, P2187, DOI 10.1345/aph.1H121
   BURKE A, 2007, GOODMAN GILLMANS PHA
   Choi HK, 2004, NEW ENGL J MED, V350, P1093, DOI 10.1056/NEJMoa035700
   Choi HK, 2007, AM J MED, V120, P442, DOI 10.1016/j.amjmed.2006.06.040
   Choi HK, 2007, ARTHRIT RHEUM-ARTHR, V57, P109, DOI 10.1002/art.22466
   Emmerson BT, 1996, NEW ENGL J MED, V334, P445, DOI 10.1056/NEJM199602153340707
   FACCHINI F, 1991, JAMA-J AM MED ASSOC, V266, P3008, DOI 10.1001/jama.266.21.3008
   Fam A G, 2001, Curr Rheumatol Rep, V3, P29, DOI 10.1007/s11926-001-0048-8
   Fukunari A, 2004, J PHARMACOL EXP THER, V311, P519, DOI 10.1124/jpet.104.070433
   Gardiner SJ, 2006, PHARMACOL REV, V58, P521, DOI 10.1124/pr.58.3.6
   George J, 2006, CIRCULATION, V114, P2508, DOI 10.1161/CIRCULATIONAHA.106.651117
   Grabowski BA, 2005, ARTHRITIS RHEUM-US, V52, pS103
   Gur M, 2008, INT J CLIN PRACT, V62, P138, DOI 10.1111/j.1742-1241.2006.01202.x
   Gur M, 2008, ANGIOLOGY, V59, P166, DOI 10.1177/0003319706292010
   Hakoda Masayuki, 2008, Nihon Rinsho, V66, P647
   HALL AP, 1967, AM J MED, V42, P27, DOI 10.1016/0002-9343(67)90004-6
   HALL IH, 1990, LIFE SCI, V46, P1923, DOI 10.1016/0024-3205(90)90507-N
   Horiuchi H, 1999, RES COMMUN MOL PATH, V104, P293
   Hoshide S, 2004, NUCLEOS NUCLEOT NUCL, V23, P1117, DOI 10.1081/NCN-200027377
   Kamatani N, 2003, ARTHRITIS RHEUM, V48, pS530
   Kanbay M, 2007, INT UROL NEPHROL, V39, P1227, DOI 10.1007/s11255-007-9253-3
   Khosravan R, 2006, J CLIN PHARMACOL, V46, P88, DOI 10.1177/0091270005282634
   Khosravan R, 2005, ARTHRITIS RHEUM-US, V52, pS102
   Khosravan R, 2008, J CLIN PHARMACOL, V48, P1014, DOI 10.1177/0091270008322035
   Khosravan R, 2008, BRIT J CLIN PHARMACO, V65, P355, DOI 10.1111/j.1365-2125.2007.03016.x
   Khosravan R, 2006, CLIN PHARMACOKINET, V45, P821, DOI 10.2165/00003088-200645080-00005
   Khosravan R, 2006, J CLIN PHARMACOL, V46, P855, DOI 10.1177/0091270006289848
   KLAASEN CD, 2007, GOODMAN GILLMANS PHA
   KOMORIYA K, 1993, EUR J PHARMACOL, V250, P455, DOI 10.1016/0014-2999(93)90033-E
   Kramer HM, 2002, AM J KIDNEY DIS, V40, P37, DOI 10.1053/ajkd.2002.33911
   Krishnan E, 2007, HYPERTENSION, V49, P298, DOI 10.1161/01.HYP.0000254480.64564.b6
   Kuehl GE, 2005, DRUG METAB DISPOS, V33, P1027, DOI 10.1124/dmd.104.002527
   LAWRENCE ME, 2006, NEW ENGL J MED, V354, P1532
   Lawrence RC, 2008, ARTHRITIS RHEUM, V58, P26, DOI 10.1002/art.23176
   Li-Yu J, 2001, J RHEUMATOL, V28, P577
   Markel A, 2005, ISR MED ASSOC J, V7, P656
   Mayer Michael D, 2005, Am J Ther, V12, P22, DOI 10.1097/00045391-200501000-00005
   Mikuls TR, 2005, ANN RHEUM DIS, V64, P267, DOI 10.1136/ard.2004.024091
   Mukoyoshi M, 2008, XENOBIOTICA, V38, P496, DOI 10.1080/00498250801956350 
   Muscelli E, 1996, AM J HYPERTENS, V9, P746, DOI 10.1016/0895-7061(96)00098-2
   Nuki G, 2006, ARTHRITIS RES THER, V8, DOI 10.1186/ar1906
   OSADA Y, 1993, EUR J PHARMACOL, V241, P183, DOI 10.1016/0014-2999(93)90201-R
   PATEL M, 1995, PHARMACOGENETICS, V5, P287, DOI 10.1097/00008571-199510000-00004
   Pereira S, 1998, Acta Med Port, V11, P1141
   Sánchez-Lozada LG, 2008, NEPHRON PHYSIOL, V108, P69, DOI 10.1159/000127837
   Sánchez-Lozada LG, 2008, AM J PHYSIOL-RENAL, V294, pF710, DOI 10.1152/ajprenal.00454.2007
   SATO S, 1991, ADV EXP MED BIOL, V309, P135
   Schumacher HR, 2007, ANN RHEUM DIS, V66, P234
   Schumacher HR, 2009, RHEUMATOLOGY, V48, P188, DOI 10.1093/rheumatology/ken457
   Schumacher HR, 2008, ARTHRIT RHEUM-ARTHR, V59, P1540, DOI 10.1002/art.24209
   Shoji A, 2004, ARTHRIT RHEUM-ARTHR, V51, P321, DOI 10.1002/art.20405
   Strazzullo P, 2007, NUTR METAB CARDIOVAS, V17, P409, DOI 10.1016/j.numecd.2007.02.011
   Sundström J, 2005, HYPERTENSION, V45, P28, DOI 10.1161/01.HYP.0000150784.92944.9a
   Takano Y, 2005, LIFE SCI, V76, P1835, DOI 10.1016/j.lfs.2004.10.031
   Taylor WJ, 2007, RHEUMATOLOGY, V46, P1751, DOI 10.1093/rheumatology/kem178
   terMaaten JC, 1997, CLIN SCI, V92, P51
   Wallace KL, 2004, J RHEUMATOL, V31, P1582
   WALLACE SL, 1977, ARTHRITIS RHEUM-US, V20, P895, DOI 10.1002/art.1780200320
   Winnard D, 2008, NEW ZEAL MED J, V121, P79
   Wortmann R, 2004, ARTHRITIS RHEUM, V50, pS335
   WORTMANN RL, 1985, J RHEUMATOL, V12, P540
NR 68
TC 12
Z9 12
U1 0
U2 5
PU PROUS SCIENCE, SAU-THOMSON REUTERS
PI BARCELONA
PA 398 PROVENCA, 08025 BARCELONA, SPAIN
SN 1699-3993
EI 1699-4019
J9 DRUG TODAY
JI Drugs Today
PD APR
PY 2009
VL 45
IS 4
BP 247
EP 260
DI 10.1358/dot.2009.045.004.1354217
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 652QJ
UT WOS:000282024400001
PM 19499090
DA 2025-06-11
ER

PT J
AU Paulin, R
   Dromparis, P
   Sutendra, G
   Gurtu, V
   Zervopoulos, S
   Bowers, L
   Haromy, A
   Webster, L
   Provencher, S
   Bonnet, S
   Michelakis, ED
AF Paulin, Roxane
   Dromparis, Peter
   Sutendra, Gopinath
   Gurtu, Vikram
   Zervopoulos, Sotirios
   Bowers, Lyndsay
   Haromy, Alois
   Webster, Linda
   Provencher, Steeve
   Bonnet, Sebastien
   Michelakis, Evangelos D.
TI Sirtuin 3 Deficiency Is Associated with Inhibited Mitochondrial Function
   and Pulmonary Arterial Hypertension in Rodents and Humans
SO CELL METABOLISM
LA English
DT Article
ID SMOOTH-MUSCLE-CELLS; INSULIN-RESISTANCE; DEOXYCORTICOSTERONE ACETATE;
   LYSINE ACETYLATION; METABOLIC SYNDROME; SKELETAL-MUSCLE; HYPOXIA; MICE;
   CHANNEL; STRESS
AB Suppression of mitochondrial function promoting proliferation and apoptosis suppression has been described in the pulmonary arteries and extrapulmonary tissues in pulmonary arterial hypertension (PAH), but the cause of this metabolic remodeling is unknown. Mice lacking sirtuin 3 (SIRT3), a mitochondrial deacetylase, have increased acetylation and inhibition of many mitochondrial enzymes and complexes, suppressing mitochondrial function. Sirt3KO mice develop spontaneous PAH, exhibiting previously described molecular features of PAH pulmonary artery smooth muscle cells (PASMC). In human PAH PASMC and rats with PAH, SIRT3 is downregulated, and its normalization with adenovirus gene therapy reverses the disease phenotype. A loss-of-function SIRT3 polymorphism, linked to metabolic syndrome, is associated with PAH in an unbiased cohort of 162 patients and controls. If confirmed in large patient cohorts, these findings may facilitate biomarker and therapeutic discovery programs in PAH.
C1 [Paulin, Roxane; Dromparis, Peter; Sutendra, Gopinath; Gurtu, Vikram; Zervopoulos, Sotirios; Bowers, Lyndsay; Haromy, Alois; Webster, Linda; Michelakis, Evangelos D.] Univ Alberta, Dept Med, Edmonton, AB T6G 2B7, Canada.
   [Provencher, Steeve; Bonnet, Sebastien] Univ Laval, Dept Med, IUCPQ Res Ctr, Pulm Hypertens Res Grp, Quebec City, PQ G1V 4G5, Canada.
C3 University of Alberta; Laval University
RP Michelakis, ED (corresponding author), Univ Alberta, Dept Med, Edmonton, AB T6G 2B7, Canada.
EM em2@ualberta.ca
RI Zervopoulos, Sotirios/E-3200-2016; Gurtu, Vikram/G-5299-2016
OI Michelakis, Evangelos/0000-0003-0787-7721; Zervopoulos,
   Sotirios/0000-0002-2958-9053
FU Canadian Institutes for Health Research; Alberta Innovates-Health
   Solutions; Alberta Innovates-Health Solutions, a Canada Research Chair;
   Mazankowski Alberta Heart Institute/University Hospital Foundation
FX R.P. is funded by Canadian Institutes for Health Research and Alberta
   Innovates-Health Solutions postdoctoral fellowships. E. D. M. is funded
   by the Canadian Institutes for Health Research, which funded this work,
   the Alberta Innovates-Health Solutions, a Canada Research Chair (Tier I)
   in applied molecular and mitochondrial medicine, and by a grant from the
   Mazankowski Alberta Heart Institute/University Hospital Foundation.
CR Ahn BH, 2008, P NATL ACAD SCI USA, V105, P14447, DOI 10.1073/pnas.0803790105
   Allison SJ, 2007, CELL CYCLE, V6, P2669, DOI 10.4161/cc.6.21.4866
   Archer SL, 1998, J CLIN INVEST, V101, P2319, DOI 10.1172/JCI333
   Archer SL, 2008, AM J PHYSIOL-HEART C, V294, pH570, DOI 10.1152/ajpheart.01324.2007
   Archer SL, 2013, NEW ENGL J MED, V369, P2236, DOI 10.1056/NEJMra1215233
   Bellizzi D, 2007, GENOMICS, V89, P143, DOI 10.1016/j.ygeno.2006.09.004
   Benigni A, 2009, J CLIN INVEST, V119, P524, DOI 10.1172/JCI36703
   Bonnet S, 2007, P NATL ACAD SCI USA, V104, P11418, DOI 10.1073/pnas.0610467104
   Bonnet S, 2007, CANCER CELL, V11, P37, DOI 10.1016/j.ccr.2006.10.020
   Bonnet S, 2006, CIRCULATION, V113, P2630, DOI 10.1161/CIRCULATIONAHA.105.609008
   CHEN LB, 1988, ANNU REV CELL BIOL, V4, P155, DOI 10.1146/annurev.cb.04.110188.001103
   Courboulin Audrey, 2011, Respir Res, V12, P128, DOI 10.1186/1465-9921-12-128
   Derdák Z, 2006, CARCINOGENESIS, V27, P956, DOI 10.1093/carcin/bgi335
   Dromparis P, 2013, CIRC RES, V113, P126, DOI 10.1161/CIRCRESAHA.112.300699
   Finley LWS, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023295
   Finley LWS, 2011, CANCER CELL, V19, P416, DOI 10.1016/j.ccr.2011.02.014
   Funkat A, 2004, J NUTR, V134, P3264, DOI 10.1093/jn/134.12.3264
   Germain M, 2013, NAT GENET, V45, P518, DOI 10.1038/ng.2581
   Giralt A, 2011, J BIOL CHEM, V286, P16958, DOI 10.1074/jbc.M110.202390
   Hansmann G, 2007, CIRCULATION, V115, P1275, DOI 10.1161/CIRCULATIONAHA.106.663120
   Hartner A, 2003, NEPHROL DIAL TRANSPL, V18, P1999, DOI 10.1093/ndt/gfg299
   He WJ, 2012, TRENDS ENDOCRIN MET, V23, P467, DOI 10.1016/j.tem.2012.07.004
   Hirschey MD, 2011, MOL CELL, V44, P177, DOI 10.1016/j.molcel.2011.07.019
   Jing EX, 2013, DIABETES, V62, P3404, DOI 10.2337/db12-1650
   Kim HS, 2010, CANCER CELL, V17, P41, DOI 10.1016/j.ccr.2009.11.023
   Kluge R, 2005, J NUCL MED, V46, P25
   Lauzier MC, 2007, ENDOCRINOLOGY, V148, P4023, DOI 10.1210/en.2007-0285
   Lombard DB, 2007, MOL CELL BIOL, V27, P8807, DOI 10.1128/MCB.01636-07
   Macián F, 2001, ONCOGENE, V20, P2476, DOI 10.1038/sj.onc.1204386
   MacKenzie ED, 2007, MOL CELL BIOL, V27, P3282, DOI 10.1128/MCB.01927-06
   Marsboom G, 2012, CIRC RES, V110, P1484, DOI 10.1161/CIRCRESAHA.111.263848
   Mata M, 2012, OXID MED CELL LONGEV, V2012, DOI 10.1155/2012/236572
   McMurtry MS, 2005, J CLIN INVEST, V115, P1479, DOI 10.1172/JCI23203
   Michelakis ED, 2010, SCI TRANSL MED, V2, DOI 10.1126/scitranslmed.3000677
   Michelakis ED, 2002, CIRC RES, V90, P1307, DOI 10.1161/01.RES.0000024689.07590.C2
   MORRELL NW, 1995, J CLIN INVEST, V96, P1823, DOI 10.1172/JCI118228
   Pastorino JG, 2005, CANCER RES, V65, P10545, DOI 10.1158/0008-5472.CAN-05-1925
   Paulin R, 2011, CIRCULATION, V123, P1205, DOI 10.1161/CIRCULATIONAHA.110.963314
   Petersen KF, 2004, NEW ENGL J MED, V350, P664, DOI 10.1056/NEJMoa031314
   Pugh ME, 2011, J HEART LUNG TRANSPL, V30, P904, DOI 10.1016/j.healun.2011.02.016
   Reeves MB, 2007, SCIENCE, V316, P1345, DOI 10.1126/science.1142984
   Ryan JJ, 2013, AM J RESP CRIT CARE, V187, P865, DOI 10.1164/rccm.201209-1687OC
   Samant SA, 2014, MOL CELL BIOL, V34, P807, DOI 10.1128/MCB.01483-13
   Schlicker C, 2008, J MOL BIOL, V382, P790, DOI 10.1016/j.jmb.2008.07.048
   Shen HQ, 2006, OBESITY, V14, P656, DOI 10.1038/oby.2006.74
   Shulga N, 2012, J CELL SCI, V125, P2995, DOI 10.1242/jcs.103093
   Simoneau JA, 1997, J APPL PHYSIOL, V83, P166, DOI 10.1152/jappl.1997.83.1.166
   Sutendra G, 2013, ONCOGENE, V32, P1638, DOI 10.1038/onc.2012.198
   Sutendra G, 2014, CELL METAB, V19, P558, DOI 10.1016/j.cmet.2014.01.004
   Sutendra G, 2013, FRONT ONCOL, V3, DOI 10.3389/fonc.2013.00038
   Wang Q, 2002, J AM SOC NEPHROL, V13, DOI 10.1097/01.ASN.0000017902.77985.84
   Waypa GB, 2013, AM J RESP CELL MOL, V49, P885, DOI 10.1165/rcmb.2013-0191OC
   West J, 2013, EUR RESPIR J, V41, P861, DOI 10.1183/09031936.00030312
   Xu WL, 2007, P NATL ACAD SCI USA, V104, P1342, DOI 10.1073/pnas.0605080104
   Yuan XJ, 1998, LANCET, V351, P726, DOI 10.1016/S0140-6736(05)78495-6
   Zamanian RT, 2009, EUR RESPIR J, V33, P318, DOI 10.1183/09031936.00000508
   Zhao L, 2013, CIRCULATION, V128, P1214, DOI 10.1161/CIRCULATIONAHA.113.004136
   Zhao SM, 2010, SCIENCE, V327, P1000, DOI 10.1126/science.1179689
NR 58
TC 165
Z9 184
U1 0
U2 22
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD NOV 4
PY 2014
VL 20
IS 5
BP 827
EP 839
DI 10.1016/j.cmet.2014.08.011
PG 13
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA AT4YF
UT WOS:000344947800018
PM 25284742
DA 2025-06-11
ER

PT J
AU Lavagnino, L
   Amianto, F
   Caprino, MP
   Maccario, M
   Arvat, E
   Ghigo, E
   Daga, GA
   Fassino, S
AF Lavagnino, Luca
   Amianto, Federico
   Caprino, Mirko Parasiliti
   Maccario, Mauro
   Arvat, Emanuela
   Ghigo, Ezio
   Daga, Giovanni Abbate
   Fassino, Secondo
TI Urinary cortisol and psychopathology in obese binge eating subjects
SO APPETITE
LA English
DT Article
DE Binge eating; HPA axis; Stress; Obesity
ID PITUITARY-ADRENAL AXIS; POSTTRAUMATIC-STRESS-DISORDER; METABOLIC
   SYNDROME; COMFORT FOOD; WOMEN; PATHOPHYSIOLOGY; HYPOCORTISOLISM;
   FIBROMYALGIA; VALIDATION; EXPOSURE
AB Background: Investigations on the relationship between obesity, binge eating and the function of hypothalamic-pituitary-adrenal (HPA) aids have led to inconsistent results. General psychopathology affects HPA axis function. The present study aims to examine correlations between binge eating, general psychopathology and HPA axis function in obese binge eaters. Methods: Twenty-four hour urinary free cortisol (UFC/24 h) was measured in 71 obese binge eating women. The patients were administered psychometric tests investigating binge eating, psychopathology and clinical variables. The relationship between binge eating, psychopathology and urinary cortisol was investigated, controlling for age and BMI. Results: We found an inverse correlation between UFC/24 h and binge eating, depression, obsessive-compusive symptoms, somatization and sensitivity. In a regression model a significant inverse correlation between urinary cortisol and psychopathology was confirmed. Conclusions: Urinary cortisol levels in obese patients with binge eating disorder show an inverse correlation with several dimensions of psychopathology which are considered to be typical of a cluster of psychiatric disorders characterized by low HPA axis function, and are very common in obese binge eating patients. If these results are confirmed, UFC/24 h might be considered a biomarker of psychopathology in obese binge eaters. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Lavagnino, Luca; Amianto, Federico; Daga, Giovanni Abbate; Fassino, Secondo] Univ Turin, Reg Pilot Ctr Eating Disorders, Psychiat Sect, Dept Neurosci, I-10124 Turin, Italy.
   [Caprino, Mirko Parasiliti; Maccario, Mauro; Arvat, Emanuela; Ghigo, Ezio] Univ Turin, Dept Med Sci, Div Endocrinol Diabetol & Metab, I-10124 Turin, Italy.
C3 University of Turin; University of Turin
RP Lavagnino, L (corresponding author), Univ Turin, Reg Pilot Ctr Eating Disorders, Psychiat Sect, Dept Neurosci, I-10124 Turin, Italy.
EM luca.lavagnino1977@gmail.com
RI Parasiliti-Caprino, Mirko/ABB-2735-2020; Abbate Daga,
   Giovanni/AAE-3155-2022
OI ARVAT, Emanuela/0000-0001-5689-4400; Abbate-Daga,
   Giovanni/0000-0002-5826-5664; Parasiliti-Caprino,
   Mirko/0000-0002-6930-7073
CR Abraham SB, 2013, OBESITY, V21, pE105, DOI 10.1002/oby.20083
   [Anonymous], 2000, DIAGN STAT MAN MENT
   Coutinho Walmir F, 2007, Eat Behav, V8, P59, DOI 10.1016/j.eatbeh.2006.01.002
   de Kloet CS, 2006, J PSYCHIATR RES, V40, P550, DOI 10.1016/j.jpsychires.2005.08.002
   Delahanty DL, 2000, BIOL PSYCHIAT, V48, P940, DOI 10.1016/S0006-3223(00)00896-9
   DEROGATIS LR, 1976, BRIT J PSYCHIAT, V128, P280, DOI 10.1192/bjp.128.3.280
   Duclos M, 2005, OBES RES, V13, P1157, DOI 10.1038/oby.2005.137
   Ehlert U, 2013, PSYCHONEUROENDOCRINO, V38, P1850, DOI 10.1016/j.psyneuen.2013.06.007
   Fries E, 2005, PSYCHONEUROENDOCRINO, V30, P1010, DOI 10.1016/j.psyneuen.2005.04.006
   Gluck ME, 2006, APPETITE, V46, P26, DOI 10.1016/j.appet.2005.05.004
   Gluck ME, 2004, ANN NY ACAD SCI, V1032, P202, DOI 10.1196/annals.1314.021
   Gluck ME, 2004, PSYCHOSOM MED, V66, P876, DOI 10.1097/01.psy.0000143637.63508.47
   GORMALLY J, 1982, ADDICT BEHAV, V7, P47, DOI 10.1016/0306-4603(82)90024-7
   Griep EN, 1998, J RHEUMATOL, V25, P1374
   Gunstad J, 2006, PSYCHIAT RES, V142, P31, DOI 10.1016/j.psychres.2005.11.007
   Handwerger K, 2009, HARVARD REV PSYCHIAT, V17, P184, DOI 10.1080/10673220902996775
   Heim C, 2000, PSYCHONEUROENDOCRINO, V25, P1, DOI 10.1016/S0306-4530(99)00035-9
   Hudson JI, 2007, BIOL PSYCHIAT, V61, P348, DOI 10.1016/j.biopsych.2006.03.040
   Kumari M, 2009, PSYCHONEUROENDOCRINO, V34, P1476, DOI 10.1016/j.psyneuen.2009.05.001
   Laessle RG, 2009, INT J EAT DISORDER, V42, P505, DOI [10.1016/j.appet.2011.12.007, 10.1002/eat.20648]
   Larsen JK, 2009, INT J BEHAV MED, V16, P311, DOI 10.1007/s12529-009-9036-6
   Levine MD, 1997, ANN BEHAV MED, V19, P132, DOI 10.1007/BF02883330
   Lo Sauro C, 2008, NEUROPSYCHOBIOLOGY, V57, P95, DOI 10.1159/000138912
   Miller AL, 2013, PSYCHONEUROENDOCRINO, V38, P2611, DOI 10.1016/j.psyneuen.2013.06.014
   Monteleone P, 2000, PSYCHIAT RES, V94, P121, DOI 10.1016/S0165-1781(00)00144-X
   Monteleone P, 2003, INT J EAT DISORDER, V34, P432, DOI 10.1002/eat.10199
   Nemeroff C., 1999, MONOGRAPH WYETH AYER
   Pasquali R, 2008, INT J OBESITY, V32, P1764, DOI 10.1038/ijo.2008.129
   Peterson CB, 2012, INT J EAT DISORDER, V45, P664, DOI 10.1002/eat.22008
   Pike KM, 2006, PSYCHIAT RES, V142, P19, DOI 10.1016/j.psychres.2005.10.006
   Pintor L, 2007, PROG NEURO-PSYCHOPH, V31, P1027, DOI 10.1016/j.pnpbp.2007.03.002
   Raison CL, 2003, AM J PSYCHIAT, V160, P1554, DOI 10.1176/appi.ajp.160.9.1554
   Rosenberg N, 2013, PSYCHIAT RES, V208, P156, DOI 10.1016/j.psychres.2012.09.050
   SLINKER BK, 1985, AM J PHYSIOL, V249, pR1, DOI 10.1152/ajpregu.1985.249.1.R1
   SPITZER RL, 1993, INT J EAT DISORDER, V13, P137, DOI 10.1002/1098-108X(199303)13:2<161::AID-EAT2260130204>3.0.CO;2-R
   Sriram K, 2012, PLOS COMPUT BIOL, V8, DOI 10.1371/journal.pcbi.1002379
   Tataranni PA, 1996, AM J PHYSIOL-ENDOC M, V271, pE317, DOI 10.1152/ajpendo.1996.271.2.E317
   Tomiyama AJ, 2011, PSYCHONEUROENDOCRINO, V36, P1513, DOI 10.1016/j.psyneuen.2011.04.005
   Tops M, 2008, PSYCHONEUROENDOCRINO, V33, P551, DOI 10.1016/j.psyneuen.2008.01.011
   Tryon MS, 2013, PHYSIOL BEHAV, V114, P32, DOI 10.1016/j.physbeh.2013.02.018
   Ursini F, 2011, RHEUMATOL INT, V31, P1403, DOI 10.1007/s00296-011-1885-z
   Van Steen K, 2002, STAT MED, V21, P3865, DOI 10.1002/sim.1358
   van Venrooij JAEM, 2012, SCHIZOPHRENIA BULL, V38, P272, DOI 10.1093/schbul/sbq062
   Vicennati V, 2009, OBESITY, V17, P1678, DOI 10.1038/oby.2009.76
   Vreeburg SA, 2009, ARCH GEN PSYCHIAT, V66, P617, DOI 10.1001/archgenpsychiatry.2009.50
   YANOVSKI SZ, 1993, J CLIN ENDOCR METAB, V76, P675, DOI 10.1210/jc.76.3.675
NR 46
TC 11
Z9 13
U1 1
U2 15
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0195-6663
EI 1095-8304
J9 APPETITE
JI Appetite
PD DEC 1
PY 2014
VL 83
BP 112
EP 116
DI 10.1016/j.appet.2014.08.020
PG 5
WC Behavioral Sciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Nutrition & Dietetics
GA AT3GP
UT WOS:000344824200016
PM 25149200
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Ramirez, ND
   Luque, EM
   Jones, XM
   Torres, PJ
   Espinoza, MJM
   Cantarelli, V
   Ponzio, MF
   Arja, A
   Rabaglino, MB
   Martini, AC
AF David Ramirez, Nicolas
   Mercedes Luque, Eugenia
   Michael Jones, Xaviar
   Javier Torres, Pedro
   Moreira Espinoza, Maria Jose
   Cantarelli, Veronica
   Flavia Ponzio, Marina
   Arja, Ana
   Belen Rabaglino, Maria
   Carolina Martini, Ana
TI Modulatory effects of ghrelin on sperm quality alterations induced by a
   fructose-enriched diet
SO HELIYON
LA English
DT Article
DE Cell biology; Developmental biology; Molecular biology; Diet;
   Endocrinology; Metabolic syndrome; Epididymis; Glutathione peroxidase;
   Oxidative stress; Neutral alpha-glucosidase
ID METABOLIC SYNDROME; OXIDATIVE STRESS; ANDROGEN ACTION; IN-VITRO;
   EXPRESSION; SPERMATOZOA; EPIDIDYMIS; HYPOXIA; OBESITY; LEPTIN
AB The objectives of this study were: 1) to evaluate the effects of a fructose enriched diet (FED) on rat sperm quality, epididymal function (i.e. oxidative stress and alpha-glucosidase expression) and testosterone concentrations; 2) to determine if the administration of ghrelin (Ghrl), reverses the effects induced by FED.
   After validating the protocol as an inductor of metabolic syndrome like-symptoms, adult male rats were assigned to one of the following treatments for 8 weeks: FED = 10% fructose enriched in water (v/v); FED + Ghrl = fructose enriched diet plus Ghrl (6 nmol/animal/day, s.c.) from week 6-8; or C = water without fructose (n = 5-10 animals/group).
   FED significantly decreased sperm concentration and motile sperm count/ml vs C (FED: 19.0 +/- 1.6 x 10(6)sperm/ml and 834.6 +/- 137.0, respectively vs C: 25.8 +/- 2.8 x 10(6) and 1300.4 +/- 202.4, respectively; p < 0.05); ghrelin injection reversed this negative effect (23.5 + 1.6 x 10(6)sperm/ml and 1381.7 +/- 71.3 respectively). FED resulted in hypogonadism, but Ghrl could not normalize testosterone concentrations (C: 1.4 +/- 0.1 ng/ml vs FED: 0.8 +/- 0.2 ng/ml and FED + Ghrl: 0.6 +/- 0.2 ng/ml; p < 0.05). Ghrelin did not reverse metabolic abnormalities secondary to FED. FED did not alter epididymal expression of antioxidants enzymes (superoxido-dismutase, catalase and glutathione peroxidases -Gpx-). Nevertheless, FED + Ghrl significantly increased the expression of Gpx3 (FED + Ghrl: 3.47 +/- 0.48 vs FED: 0.69 +/- 0.28 and C: 1.00 +/- 0.14; p < 0.05). The expression of neutral alpha-glucosidase, which is a marker of epididymal function, did not differ between treatments.
   In conclusion, the administration of Ghrl modulated the negative effects of FED on sperm quality, possibly by an epididymal increase in Gpx3 expression. However, Ghrl could not neither normalize the metabolism of FED animals, nor reverse hypogonadism.
C1 [David Ramirez, Nicolas; Mercedes Luque, Eugenia; Michael Jones, Xaviar; Javier Torres, Pedro; Cantarelli, Veronica; Flavia Ponzio, Marina; Arja, Ana; Carolina Martini, Ana] Univ Nacl Cordoba, Inst Fisiol, Fac Ciencias Med, Santa Rosa 1085,X5000ESU, Cordoba, Argentina.
   [Javier Torres, Pedro; Cantarelli, Veronica; Flavia Ponzio, Marina; Belen Rabaglino, Maria; Carolina Martini, Ana] Univ Nacl Cordoba, Inst Invest Ciencias Salud INICSA, CONICET, Fac Ciencias Med, Pabellon Biol Celular,Ciudad Univ, RA-5016 Cordoba, Argentina.
   [Moreira Espinoza, Maria Jose] Univ Nacl Cordoba, Fac Ciencias Med, Inst Biol Celular, Ciudad Univ, RA-5016 Cordoba, Argentina.
C3 National University of Cordoba; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); National University of Cordoba;
   National University of Cordoba
RP Martini, AC (corresponding author), Univ Nacl Cordoba, Inst Fisiol, Fac Ciencias Med, Santa Rosa 1085,X5000ESU, Cordoba, Argentina.; Martini, AC (corresponding author), Univ Nacl Cordoba, Inst Invest Ciencias Salud INICSA, CONICET, Fac Ciencias Med, Pabellon Biol Celular,Ciudad Univ, RA-5016 Cordoba, Argentina.
EM acmartini2000@yahoo.com
RI Cantarelli, Verónica/H-5414-2018
OI Arja, Ahmed/0009-0007-4001-7041; Rabaglino, Maria
   Belen/0000-0002-0099-045X; Jones, Xaviar/0000-0003-1815-4166;
   Moreira-Espinoza, Maria Jose/0000-0003-2398-296X; Cantarelli, Veronica
   Ines/0000-0002-2974-886X
FU Secretaria de Ciencia y Tecnologia, Universidad Nacional de Cordoba
   (SECyT-UNC)
FX This work was supported by grants from the Secretaria de Ciencia y
   Tecnologia, Universidad Nacional de Cordoba (SECyT-UNC).
CR Asadi N, 2018, ANDROLOGIA, V50, DOI 10.1111/and.13106
   Barazzoni R, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026224
   Beaumont NJ, 2003, J BIOL CHEM, V278, P8877, DOI 10.1074/jbc.C200575200
   Catak Z, 2014, NEUROPEPTIDES, V48, P167, DOI 10.1016/j.npep.2014.04.002
   Chen CY, 2009, PHARMACOL REV, V61, P430, DOI 10.1124/pr.109.001958
   Cooper CL, 1998, THEORIES OF ORGANIZATIONAL STRESS, P1
   DECUNEO MF, 1994, J EXP ANIM SCI, V36, P189
   Devret J.R., 2000, AQUILAITALY COLLANAS, V2000, P427
   Dixit VD, 2004, J CLIN INVEST, V114, P57, DOI 10.1172/JCI200421134
   Dobutovic B, 2014, ARCH MED SCI, V10, P806, DOI 10.5114/aoms.2014.44872
   Drevet JR, 2006, MOL CELL ENDOCRINOL, V250, P70, DOI 10.1016/j.mce.2005.12.027
   El Eter E, 2007, J GASTROEN HEPATOL, V22, P1791, DOI 10.1111/j.1440-1746.2006.04696.x
   Ferramosca A, 2017, ANDROLOGY-US, V5, P423, DOI 10.1111/andr.12348
   Foresta C, 2002, BIOL REPROD, V67, P967, DOI 10.1095/biolreprod.102.003822
   García MC, 2007, REPRODUCTION, V133, P531, DOI 10.1530/REP-06-0249
   Hirsh A, 2003, BMJ-BRIT MED J, V327, P669, DOI 10.1136/bmj.327.7416.669
   Imai H, 2009, J BIOL CHEM, V284, P32522, DOI 10.1074/jbc.M109.016139
   Kasturi SS, 2008, J ANDROL, V29, P251, DOI 10.2164/jandrol.107.003731
   Kheradmand A, 2015, ANDROLOGIA, V47, P634, DOI 10.1111/and.12311
   Kheradmand A, 2010, REGUL PEPTIDES, V162, P84, DOI 10.1016/j.regpep.2010.02.008
   Kojima M, 1999, NATURE, V402, P656, DOI 10.1038/45230
   Kojima M, 2005, PHYSIOL REV, V85, P495, DOI 10.1152/physrev.00012.2004
   KOVACS A, 1992, BIOTECH HISTOCHEM, V67, P119, DOI 10.3109/10520299209110020
   Larson JL, 1999, MOL REPROD DEV, V52, P445, DOI 10.1002/(SICI)1098-2795(199904)52:4<445::AID-MRD14>3.0.CO;2-6
   Leisegang K, 2014, ANDROLOGIA, V46, P167, DOI 10.1111/and.12060
   Leisegang K, 2016, AM J REPROD IMMUNOL, V76, P155, DOI 10.1111/aji.12529
   Lotti F, 2013, ANDROLOGY-US, V1, P229, DOI 10.1111/j.2047-2927.2012.00031.x
   Luque EM, 2017, REPROD FERT DEVELOP, V29, P731, DOI 10.1071/RD15351
   Mahmoud AM, 1998, HUM REPROD, V13, P591, DOI 10.1093/humrep/13.3.591
   Makhsida N, 2005, J UROLOGY, V174, P827, DOI 10.1097/01.ju.0000169490.78443.59
   MAKLER A, 1980, FERTIL STERIL, V33, P337
   Mallidis C, 2011, REPRODUCTION, V142, P63, DOI 10.1530/REP-10-0472
   Marchiani S, 2015, MOL CELL ENDOCRINOL, V401, P12, DOI 10.1016/j.mce.2014.11.005
   Martini AC, 2010, FERTIL STERIL, V94, P1739, DOI 10.1016/j.fertnstert.2009.11.017
   Michalakis K, 2013, METABOLISM, V62, P457, DOI 10.1016/j.metabol.2012.08.012
   Noblanc A, 2011, J ANDROL, V32, P641, DOI 10.2164/jandrol.110.012823
   Oliva MM, 2016, INT J ENDOCRINOL, V2016, DOI 10.1155/2016/1674950
   Omrani H, 2017, HIGH ALT MED BIOL, V18, P145, DOI 10.1089/ham.2016.0132
   Omrani H, 2015, ADV PHARM BULL, V5, P283, DOI 10.15171/apb.2015.039
   Oztas B, 2017, NEUROPEPTIDES, V61, P31, DOI 10.1016/j.npep.2016.08.002
   Pilatz A, 2017, ANDROLOGY-US, V5, P23, DOI 10.1111/andr.12296
   Pulkkinen L., 2010, INT J PEPT PROT RES, V2010, P248948, DOI [10.1155/2010/248948, DOI 10.1155/2010/248948]
   Robaire B, 2011, J ANDROL, V32, P592, DOI 10.2164/jandrol.111.014266
   Rodríguez V, 2017, ARCH BIOCHEM BIOPHYS, V636, P1, DOI 10.1016/j.abb.2017.11.002
   Rosety I, 2014, REV MED CHILE, V142, P732, DOI 10.4067/S0034-98872014000600007
   Sipilä P, 2011, J ANDROL, V32, P711, DOI 10.2164/jandrol.110.012914
   Srikanthan K, 2016, INT J MED SCI, V13, P25, DOI 10.7150/ijms.13800
   Sullivan R, 2016, HUM REPROD UPDATE, V22, P574, DOI 10.1093/humupd/dmw015
   Taran M., 2018, SM J CARDIOL CARDIOV, V4, P1021
   Ukkola O, 2006, ANN MED, V38, P274, DOI 10.1080/07853890600622192
   Ukkola O, 2009, CURR PROTEIN PEPT SC, V10, P2, DOI 10.2174/138920309787315220
   Ventimiglia E, 2016, ANDROLOGY-US, V4, P944, DOI 10.1111/andr.12232
   Xiang AS, 2019, LANCET DIABETES ENDO, V7, P575, DOI 10.1016/S2213-8587(19)30003-8
NR 53
TC 6
Z9 6
U1 0
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
EI 2405-8440
J9 HELIYON
JI Heliyon
PD NOV
PY 2019
VL 5
IS 11
AR e02886
DI 10.1016/j.heliyon.2019.e02886
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA JS8CO
UT WOS:000500530100139
PM 31844755
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chang, CC
   Chen, PS
   Lin, JR
   Chen, YA
   Liu, CS
   Lin, TT
   Chang, HH
AF Chang, Cheng-Chen
   Chen, Po See
   Lin, Jhih-Rong
   Chen, Yi-An
   Liu, Chin-San
   Lin, Ta-Tsung
   Chang, Hui Hua
TI Mitochondrial DNA Copy Number Is Associated With Treatment Response and
   Cognitive Function in Euthymic Bipolar Patients Receiving Valproate
SO INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE Bipolar disorder; cognitive function; metabolic syndrome; mitochondrial
   DNA copy number; valproate
ID METABOLIC SYNDROME; IMPAIRMENT; DISORDER; DYSFUNCTION; DEPRESSION;
   DEFICITS; LITHIUM; BLOOD; ACID
AB Background Bipolar disorder (BD) is associated with cognitive impairment and mitochondrial dysfunction. However, the associations among mitochondrial DNA copy number (MCN), treatment response, and cognitive function remain elusive in BD patients. Methods Sixty euthymic BD patients receiving valproate (VPA) and 66 healthy controls from the community were recruited. The indices of metabolic syndrome (MetS) were measured. Quantitative polymerase chain reaction analysis of blood leukocytes was used to measure the MCN. Cognitive function was measured by calculating perseverative errors and completed categories on the Wisconsin Card Sorting Test (WCST). The VPA treatment response was measured using the Alda scale. Results BD patients had significantly higher MCN, triglyceride, and C-reactive protein (CRP) levels, waist circumference, and worse performance on the WCST than the controls. Regression models showed that BD itself and the VPA concentration exerted significant effects on increased MCN levels. Moreover, the receiver operating characteristic curve analysis showed that an MCN of 2.05 distinguished VPA responders from nonresponders, with an area under the curve of 0.705 and a sensitivity and specificity of 0.529 and 0.816, respectively. An MCN level >= 2.05 was associated with 5.39 higher odds of being a VPA responder (P = .006). BD patients who were stratified into the high-MCN group had a higher VPA response rate, better WCST performance, lower CRP level, and less MetS. Conclusions The study suggests a link between the peripheral MCN and cognitive function in BD patients. As an inflammatory status, MetS might modulate this association.
C1 [Chang, Cheng-Chen] Chung Shan Med Univ, Sch Med, Taichung, Taiwan.
   [Chang, Cheng-Chen] Chung Shan Med Univ Hosp, Dept Psychiat, Taichung, Taiwan.
   [Chen, Po See] Natl Cheng Kung Univ, Coll Med, Dept Psychiat, Tainan, Taiwan.
   [Chen, Po See] Natl Cheng Kung Univ, Coll Med, Inst Behav Med, Tainan, Taiwan.
   [Lin, Jhih-Rong; Chen, Yi-An; Chang, Hui Hua] Natl Cheng Kung Univ, Coll Med, Inst Clin Pharm & Pharmaceut Sci, Tainan, Taiwan.
   [Liu, Chin-San; Lin, Ta-Tsung] Changhua Christian Hosp, Vasc & Genom Res Ctr, Changhua, Taiwan.
   [Liu, Chin-San] China Med Univ, Coll Chinese Med, Grad Inst Integrated Med, Taichung, Taiwan.
   [Chang, Hui Hua] Natl Cheng Kung Univ, Coll Med, Sch Pharm, Tainan, Taiwan.
   [Chang, Hui Hua] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Pharm, Tainan, Taiwan.
   [Chang, Hui Hua] Natl Cheng Kung Univ Hosp, Dept Pharm, Dou Liou Branch, Touliu, Yunlin, Taiwan.
C3 Chung Shan Medical University; Chung Shan Medical University; Chung Shan
   Medical University Hospital; National Cheng Kung University; National
   Cheng Kung University; National Cheng Kung University; Changhua
   Christian Hospital; China Medical University Taiwan; National Cheng Kung
   University; National Cheng Kung University; National Cheng Kung
   University Hospital; National Cheng Kung University; National Cheng Kung
   University Hospital
RP Chang, HH (corresponding author), Natl Cheng Kung Univ, Inst Clin Pharm & Pharmaceut Sci, 1 Univ Rd, Tainan 701, Taiwan.
EM huihua@mail.ncku.edu.tw
RI Chang, Hui/AGD-4270-2022; é™³, ç‘žå‚‘/HCH-5712-2022; Chen,
   Po/AAA-6492-2021
OI Chang, Hui Hua/0000-0001-7866-5481
FU Ministry of Science and Technology of Taiwan [MOST 105-2320-B-006-014,
   MOST 106-2320-B-006-040, MOST 107-2320-B-006-071, MOST
   108-2320-B-006-047-MY3]; National Cheng Kung University Hospital
   [NCKUH-10802013, NCKUH-10902014, NCKUH-11002026]; Changhua Christian
   Hospital [108-CCH-IRP-109]
FX We thank all the participants of this study for their exceptional
   cooperation as well as valuable contributions. We also thank Chih-Ying
   Lin for administrative support. This work was supported by the Ministry
   of Science and Technology of Taiwan (MOST 105-2320-B-006-014, MOST
   106-2320-B-006-040, MOST 107-2320-B-006-071, MOST
   108-2320-B-006-047-MY3); the National Cheng Kung University Hospital
   (NCKUH-10802013, NCKUH-10902014, NCKUH-11002026); and the Changhua
   Christian Hospital (108-CCH-IRP-109).
CR Ahn SW, 2017, INT J BIPOLAR DISORD, V5, DOI 10.1186/s40345-017-0093-5
   Bachmann RF, 2009, INT J NEUROPSYCHOPH, V12, P805, DOI 10.1017/S1461145708009802
   Bai YM, 2015, BIPOLAR DISORD, V17, P269, DOI 10.1111/bdi.12259
   Beltrán-Sarmiento E, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/7954371
   Benedetti F, 2020, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.00071
   Benros ME, 2013, JAMA PSYCHIAT, V70, P812, DOI 10.1001/jamapsychiatry.2013.1111
   Berk M, 2007, BIPOLAR DISORD, V9, P671, DOI 10.1111/j.1399-5618.2007.00484.x
   Bora E, 2017, PSYCHOL MED, V47, P2753, DOI 10.1017/S0033291717001490
   Bourne C, 2013, ACTA PSYCHIAT SCAND, V128, P149, DOI 10.1111/acps.12133
   Chang CC, 2014, PSYCHIAT CLIN NEUROS, V68, P551, DOI 10.1111/pcn.12163
   Chang HH, 2012, BRAIN BEHAV IMMUN, V26, P90, DOI 10.1016/j.bbi.2011.07.239
   Chang HH, 2022, CNS SPECTRUMS, V27, P598, DOI 10.1017/S1092852921000158
   Craft S, 2004, LANCET NEUROL, V3, P169, DOI 10.1016/S1474-4422(04)00681-7
   de Sousa RT, 2014, PROG NEURO-PSYCHOPH, V48, P32, DOI 10.1016/j.pnpbp.2013.09.002
   Delbarba A, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/5923938
   Dickerson F, 2013, J AFFECT DISORDERS, V150, P456, DOI 10.1016/j.jad.2013.04.039
   Fazzini F, 2021, J INTERN MED, V290, P190, DOI 10.1111/joim.13242
   Feng YM, 2013, AUTOPHAGY, V9, P1395, DOI 10.4161/auto.25468
   Fernandez A, 2019, NEURON, V102, P1127, DOI 10.1016/j.neuron.2019.04.013
   Fries GR, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/s41398-017-0048-8
   Furda AM, 2012, DNA REPAIR, V11, P684, DOI 10.1016/j.dnarep.2012.06.002
   Giridharan VV, 2020, MOL PSYCHIATR, V25, P94, DOI 10.1038/s41380-019-0448-7
   Green MF, 2006, J CLIN PSYCHIAT, V67, P3, DOI 10.4088/JCP.1006e12
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Hartmann N, 2011, AGING CELL, V10, P824, DOI 10.1111/j.1474-9726.2011.00723.x
   Heaton R.K., 1993, Wisconsin Card Sorting Test manual: Revised and expanded
   Huang CH, 2011, J ATHEROSCLER THROMB, V18, P867, DOI 10.5551/jat.8698
   Kapczinski F, 2011, J PSYCHIATR RES, V45, P156, DOI 10.1016/j.jpsychires.2010.05.015
   Kato T, 2000, BIPOLAR DISORD, V2, P180, DOI 10.1034/j.1399-5618.2000.020305.x
   Kato T, 2007, CNS DRUGS, V21, P1, DOI 10.2165/00023210-200721010-00001
   Kim JH, 2012, MENOPAUSE, V19, P582, DOI 10.1097/gme.0b013e31823a3e46
   Lee JW, 2010, CLIN CHIM ACTA, V411, P592, DOI 10.1016/j.cca.2010.01.024
   Li ZC, 2015, SCI REP-UK, V5, DOI 10.1038/srep18553
   Lima IMM, 2018, CLIN PSYCHOL REV, V59, P126, DOI 10.1016/j.cpr.2017.11.006
   Lopez-Candales Angel, 2017, J Nat Sci, V3
   Ximenes JCM, 2013, N-S ARCH PHARMACOL, V386, P575, DOI 10.1007/s00210-013-0853-4
   Malik AN, 2013, MITOCHONDRION, V13, P481, DOI 10.1016/j.mito.2012.10.011
   Manchia M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0065636
   Mancuso C, 2007, FRONT BIOSCI-LANDMRK, V12, P1107, DOI 10.2741/2130
   Martínez-Arán A, 2004, AM J PSYCHIAT, V161, P262, DOI 10.1176/appi.ajp.161.2.262
   Morris G, 2017, NEUROSCI BIOBEHAV R, V74, P1, DOI 10.1016/j.neubiorev.2017.01.014
   Mur M, 2008, J CLIN PSYCHIAT, V69, P712, DOI 10.4088/JCP.v69n0504
   Nordestgaard BG, 2009, NUTR METAB CARDIOVAS, V19, P521, DOI 10.1016/j.numecd.2009.07.005
   Parshall MB, 2013, HEART LUNG, V42, P221, DOI 10.1016/j.hrtlng.2013.01.006
   Rollins Brandi L, 2018, Mol Neuropsychiatry, V3, P157, DOI 10.1159/000484348
   Rudich A, 2007, TRENDS ENDOCRIN MET, V18, P291, DOI 10.1016/j.tem.2007.08.006
   Sitarz KS, 2014, MOL GENET METAB, V112, P57, DOI 10.1016/j.ymgme.2014.03.006
   Vawter MP, 2000, BIOL PSYCHIAT, V48, P486, DOI 10.1016/S0006-3223(00)00978-1
   Wang D, 2018, BMC PSYCHIATRY, V18, DOI 10.1186/s12888-018-1717-8
   Wu IC, 2017, J GERONTOL A-BIOL, V72, P937, DOI 10.1093/gerona/glx033
   Wu SW, 2019, AM J CLIN NUTR, V109, P424, DOI 10.1093/ajcn/nqy286
   Yamaki N, 2018, PSYCHIAT RES, V269, P115, DOI 10.1016/j.psychres.2018.08.014
   Zarate CA, 2000, PSYCHIAT QUART, V71, P309
NR 53
TC 7
Z9 7
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1461-1457
EI 1469-5111
J9 INT J NEUROPSYCHOPH
JI Int. J. Neuropsychopharmacol.
PD AUG 4
PY 2022
VL 25
IS 7
BP 525
EP 533
DI 10.1093/ijnp/pyab095
EA JAN 2022
PG 9
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 3N8OX
UT WOS:000756736900001
PM 34979555
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Dodd, S
   Carvalho, AF
   Puri, BK
   Maes, M
   Bortolasci, CC
   Morris, G
   Berk, M
AF Dodd, Seetal
   Carvalho, Andre F.
   Puri, Basant K.
   Maes, Michael
   Bortolasci, Chiara C.
   Morris, Gerwyn
   Berk, Michael
TI Trace Amine-Associated Receptor 1 (TAAR1): A new drug target for
   psychiatry?
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Trace Amine-Associated Receptor; SEP-363856; schizophrenia; drug target
AB There are nine subfamilies of TAARs. They are predominantly intracellular, located in the central nervous system and peripherally. They have a role in homeostasis and rheostasis, and also in olfaction. They demonstrate significant cross-talk with the monoamine system and are involved in the regulation of cAMP signalling and K+ channels. There is evidence to suggest that TAAR1 may be a promising therapeutic target for the treatment of schizophrenia, psychosis in Parkinson's disease, substance use disorders, and the metabolic syndrome and obesity. TAAR1 expression may also be a prognostic biomarker for cancers.
   A number of TAAR modulators have been identified, including endogenous ligands and new chemical entities. Some of these agents have shown efficacy in animal models of addiction behaviours, depression and anxiety. Only one agent, SEP-363856, has progressed to randomised clinical trials in humans; however further, larger studies with SEP-363856 are required to clarify its suitability as a new treatment for schizophrenia spectrum disorders. SEP-363856 is an agonist of TAAR1 and 5HT1A and it is not clear to what extent its efficacy can be attributed to TAAR1 rather than to other drug targets. However, current research suggests that TAAR1 has an important role in human physiology and pathophysiology. TAAR1 modulators may become an important new drug class for the management of a wide array of mental disorders in the future.
C1 [Dodd, Seetal; Carvalho, Andre F.; Maes, Michael; Bortolasci, Chiara C.; Morris, Gerwyn; Berk, Michael] Deakin Univ, Inst Mental & Phys Hlth & Clin Translat, Geelong, Vic, Australia.
   [Dodd, Seetal; Berk, Michael] Univ Melbourne, Ctr Youth Mental Hlth, Parkville, Vic, Australia.
   [Dodd, Seetal; Berk, Michael] Univ Melbourne, Dept Psychiat, Parkville, Vic, Australia.
   [Dodd, Seetal; Berk, Michael] Univ Hosp Geelong, Barwon Hlth, POB 281, Geelong, Vic 3220, Australia.
   [Carvalho, Andre F.] Ctr Addict & Mental Hlth CAMH, Toronto, ON, Canada.
   [Carvalho, Andre F.] Dept Psychiat, Toronto, ON, Canada.
   [Puri, Basant K.] CAR, Cambridge, England.
   [Bortolasci, Chiara C.] Deakin Univ, Sch Med, Ctr Mol & Med Res, Geelong, Vic, Australia.
C3 Deakin University; University of Melbourne; Orygen, The National Centre
   of Excellence in Youth Mental Health; University of Melbourne; Barwon
   Health; Geelong Hospital; University of Toronto; Centre for Addiction &
   Mental Health - Canada; Deakin University
RP Dodd, S (corresponding author), Deakin Univ, Inst Mental & Phys Hlth & Clin Translat, Barwon Hlth, POB 281, Geelong, Vic 3220, Australia.
EM seetald@barwonhealth.org.au
RI Carvalho, Andre/AEZ-4001-2022; Bortolasci, Chiara/C-7336-2016; Puri,
   Basant/H-8249-2019; Berk, Michael/AGH-9427-2022; Maes,
   Michael/B-8546-2011; Berk, Michael/M-7891-2013
OI Puri, Basant/0000-0001-6101-0139; Berk, Michael/0000-0002-5554-6946
FU National Health and Medical Research Council (NHMRC) Senior Principal
   Research Fellowship [APP1059660, APP1156072]
FX MB is supported by a National Health and Medical Research Council
   (NHMRC) Senior Principal Research Fellowship (APP1059660 and APP1156072)
CR Berry MD, 2017, PHARMACOL THERAPEUT, V180, P161, DOI 10.1016/j.pharmthera.2017.07.002
   BOULTON AA, 1991, PROG NEURO-PSYCHOPH, V15, P139, DOI 10.1016/0278-5846(91)90076-D
   Gwilt KB, 2020, CELL MOL NEUROBIOL, V40, P191, DOI 10.1007/s10571-019-00772-7
   Bunzow JR, 2001, MOL PHARMACOL, V60, P1181, DOI 10.1124/mol.60.6.1181
   Cichero E, 2018, EXPERT OPIN THER PAT, V28, P437, DOI 10.1080/13543776.2018.1476493
   Cisneros IE, 2014, NEUROPHARMACOLOGY, V85, P499, DOI 10.1016/j.neuropharm.2014.06.011
   Dedic N, 2019, NOVEL NOND2 PSYCHOTR
   Dedic N, 2019, J PHARMACOL EXP THER, V371, P1, DOI 10.1124/jpet.119.260281
   Espinoza S, 2020, FRONT MOL NEUROSCI, V13, DOI 10.3389/fnmol.2020.00018
   Espinoza S, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00645
   Espinoza S, 2011, MOL PHARMACOL, V80, P416, DOI 10.1124/mol.111.073304
   Fleischer LM, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00683
   Fowler S, 2015, J PHARMACOL EXP THER, V352, P358, DOI 10.1124/jpet.114.220194
   Gainetdinov RR, 2018, PHARMACOL REV, V70, P549, DOI 10.1124/pr.117.015305
   Goff DC, 2020, NEW ENGL J MED, V382, P1555, DOI 10.1056/NEJMe2001508
   Gwilt KB, 2019, IMMUNOPHARM IMMUNOT, V41, P577, DOI 10.1080/08923973.2019.1672178
   Harkness JH, 2015, NEUROPSYCHOPHARMACOL, V40, P2175, DOI 10.1038/npp.2015.61
   JONES RSG, 1982, EUR J PHARMACOL, V77, P159, DOI 10.1016/0014-2999(82)90012-7
   Koblan KS, 2020, NEW ENGL J MED, V382, P1497, DOI 10.1056/NEJMoa1911772
   Köhrle J, 2019, ENDOCR REV, V40, P602, DOI 10.1210/er.2018-00182
   Lindemann L, 2008, J PHARMACOL EXP THER, V324, P948, DOI 10.1124/jpet.107.132647
   Liu JF, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00279
   Loftis JM, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0220270
   Mühlhaus J, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00807
   Panas MW, 2012, J NEUROIMMUNE PHARM, V7, P866, DOI 10.1007/s11481-011-9321-4
   Pei Y, 2016, FRONT NEUROSCI-SWITZ, V10, DOI 10.3389/fnins.2016.00148
   Raab S, 2016, MOL METAB, V5, P47, DOI 10.1016/j.molmet.2015.09.015
   Revel FG, 2012, BIOL PSYCHIAT, V72, P934, DOI 10.1016/j.biopsych.2012.05.014
   Revel FG, 2011, P NATL ACAD SCI USA, V108, P8485, DOI 10.1073/pnas.1103029108
   Rutigliano G, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21062005
   Rutigliano G, 2020, CELL MOL NEUROBIOL, V40, P239, DOI 10.1007/s10571-019-00743-y
   Rutigliano G, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.01027
   Rutigliano G, 2018, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00987
   Shi X, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0152581
   Sriram U, 2016, J LEUKOCYTE BIOL, V99, P213, DOI 10.1189/jlb.4A0814-395RR
   Stalder H, 2011, BIOORG MED CHEM LETT, V21, P1227, DOI 10.1016/j.bmcl.2010.12.075
   Thorn DA, 2014, NEUROPSYCHOPHARMACOL, V39, P2309, DOI 10.1038/npp.2014.91
   Tonelli M, 2020, EXPERT OPIN THER PAT, V30, P137, DOI 10.1080/13543776.2020.1708900
   Vallender EJ, 2010, BMC EVOL BIOL, V10, DOI 10.1186/1471-2148-10-51
   Wolinsky TD, 2007, GENES BRAIN BEHAV, V6, P628, DOI 10.1111/j.1601-183X.2006.00292.x
   Xie ZH, 2007, J PHARMACOL EXP THER, V321, P128, DOI 10.1124/jpet.106.117382
   Zucchi R, 2006, BRIT J PHARMACOL, V149, P967, DOI 10.1038/sj.bjp.0706948
NR 42
TC 40
Z9 44
U1 0
U2 30
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD JAN
PY 2021
VL 120
BP 537
EP 541
DI 10.1016/j.neubiorev.2020.09.028
EA JAN 2021
PG 5
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA QB6VG
UT WOS:000614277700003
PM 33031817
DA 2025-06-11
ER

PT J
AU Lamar, M
   Rubin, LH
   Ajilore, O
   Charlton, R
   Zhang, AF
   Yang, SL
   Cohen, J
   Kumar, A
AF Lamar, Melissa
   Rubin, Leah H.
   Ajilore, Olusola
   Charlton, Rebecca
   Zhang, Aifeng
   Yang, Shaolin
   Cohen, Jamie
   Kumar, Anand
TI What Metabolic Syndrome Contributes to Brain Outcomes in African
   American & Caucasian Cohorts
SO CURRENT ALZHEIMER RESEARCH
LA English
DT Article
DE Affect; aging; cognition; health disparities; metabolic syndrome;
   neuroanatomy; vascular risk
ID ALZHEIMERS-DISEASE; RISK-FACTORS; COGNITIVE PERFORMANCE; PREFRONTAL
   CORTEX; VASCULAR RISK; MEMORY; ADULTS; ASSOCIATION; IMPAIRMENT;
   DEPRESSION
AB Metabolic syndrome (MetS), i.e., meeting criteria for any three of the following: hyperglycemia, hypertension, hypertriglyceridemia, low high-density lipoprotein and/or abdominal obesity, is associated with negative health outcomes. For example, MetS negatively impacts cognition; however, less is known about incremental MetS risk, i.e., meeting 1 or 2 as opposed to 3 or more criteria. We hypothesized incremental MetS risk would negatively contribute to cognition and relevant neuroanatomy, e.g., memory and hippocampal volumes, and that this risk extends to affective functioning. 119 non-demented/non-depressed participants (age=60.1+12.9;similar to 50% African American) grouped by incremental MetSrisk-no (0 criteria met), low (1-2 criteria met), or high (3+ criteria met)-were compared across cognition, affect and relevant neuroanatomy using multivariable linear regressions. Exploratory analyses, stratified by race, consider the role of health disparities in disease severity of individual MetS component (e.g., actual blood pressure readings) on significant results from primary analyses. Incremental MetS risk contributed to depressive symptomatology (no<low<high), learning and memory performance (no>low=high) after controlling for age, race (n.s.) and IQ. Different indices of disease severity contributed to different aspects of brain structure and function by race providing empirical support for future studies of the impact distinct health disparities in vascular risk have on brain aging. MetS compromised mood, cognition and hippocampal structure with incremental risk applying to some but not all of these outcomes. Care providers may wish to monitor a broader spectrum of risk including components of MetS like blood pressure and cholesterol levels when considering brain-behavior relationships in adults from diverse populations.
C1 [Lamar, Melissa; Rubin, Leah H.; Ajilore, Olusola; Charlton, Rebecca; Zhang, Aifeng; Yang, Shaolin; Cohen, Jamie; Kumar, Anand] Univ Illinois, Dept Psychiat, Chicago, IL 60612 USA.
   [Charlton, Rebecca] Univ London, Dept Psychol, London WC1E 7HU, England.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of London
RP Lamar, M (corresponding author), Univ Illinois, 1601 West Taylor St MC912, Chicago, IL 60612 USA.
EM mlamar@psych.uic.edu
RI Yang, Shaolin/NHP-2672-2025; Ajilore, Olusola/ABG-4035-2020; Ajilore,
   Olusola/A-1073-2011
OI Peven, Jamie/0000-0002-2187-5514; Ajilore, Olusola/0000-0003-0737-0437;
   Charlton, Rebecca/0000-0002-3326-8762
FU National Institue on Aging [K01 AG040192]; National Institute of Mental
   Health [7RO1 MH073989-04, K23 MH011875]
FX This work was suppoorted by the National Institue on Aging [K01 AG040192
   to M.L.] and the National Institute of Mental Health [grant numbers 7RO1
   MH073989-04 to A.K., K23 MH011875 to O.A.].
CR Ajilore O, 2015, INT J GERIATR PSYCH, V30, P393, DOI 10.1002/gps.4149
   Ajilore O, 2010, PSYCHIAT RES-NEUROIM, V184, P63, DOI 10.1016/j.pscychresns.2010.07.003
   Akiyama H, 2000, NEUROBIOL AGING, V21, P383, DOI 10.1016/S0197-4580(00)00124-X
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Amer Diabet Assoc, 2014, DIABETES CARE, V37, pS14, DOI 10.2337/dc14-S014
   [Anonymous], 2008, WAIS-IV: Administration and scoring manual
   Bove M, 2010, AGING MENT HEALTH, V14, P801, DOI 10.1080/13607861003713299
   Cahill L, 2006, NAT REV NEUROSCI, V7, P477, DOI 10.1038/nrn1909
   Cavalier M, 2010, DIABETES CARE, V33, P2489, DOI 10.2337/dc10-0851
   Charlton RA, 2014, AM J GERIAT PSYCHIAT, V22, P936, DOI 10.1016/j.jagp.2013.01.074
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Craft S, 2013, J ALZHEIMERS DIS, V33, pS263, DOI 10.3233/JAD-2012-129042
   Craft S, 2012, J GERONTOL A-BIOL, V67, P754, DOI 10.1093/gerona/gls112
   Danaei Goodarz, 2009, Popul Health Metr, V7, P16, DOI 10.1186/1478-7954-7-16
   Delis DC, 2001, DELIS KAPLAN EXECUTO
   Desikan RS, 2006, NEUROIMAGE, V31, P968, DOI 10.1016/j.neuroimage.2006.01.021
   Duru O Kenrik, 2009, Med Care, V47, P700
   FOLSTEIN MF, 1975, J PSYCHIAT RES, V12, P189, DOI 10.1016/0022-3956(75)90026-6
   Golden SH, 2004, AM J EPIDEMIOL, V160, P540, DOI 10.1093/aje/kwh250
   Gorelick PB, 2011, STROKE, V42, P2672, DOI 10.1161/STR.0b013e3182299496
   Gurland BJ, 1999, INT J GERIATR PSYCH, V14, P481, DOI 10.1002/(SICI)1099-1166(199906)14:6<481::AID-GPS959>3.3.CO;2-X
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Hassenstab JJ, 2010, DEMENT GERIATR COGN, V29, P356, DOI 10.1159/000296071
   Imano H, 2012, PREV MED, V55, P603, DOI 10.1016/j.ypmed.2012.09.013
   Kalaria RN, 2010, NUTR REV, V68, pS74, DOI 10.1111/j.1753-4887.2010.00352.x
   Kirk JK, 2008, DIABETES CARE, V31, P240, DOI 10.2337/dc07-0382
   Langsted A, 2008, CIRCULATION, V118, P2047, DOI 10.1161/CIRCULATIONAHA.108.804146
   Lee KS, 2010, ARCH GERONTOL GERIAT, V50, P69, DOI 10.1016/j.archger.2009.01.014
   Libon DJ, 1998, J CLIN EXP NEUROPSYC, V20, P30, DOI 10.1076/jcen.20.1.30.1490
   Meyer T, 2011, J NEUROSCI, V31, P6266, DOI 10.1523/JNEUROSCI.6798-10.2011
   Morikawa M, 2013, INT J GERIATR PSYCH, V28, P1251, DOI 10.1002/gps.3950
   Muller M, 2010, NEUROEPIDEMIOLOGY, V34, P83, DOI 10.1159/000264825
   NHLBI Morbidity and Mortality, 2009, NHLBI MORB MORT 2009
   Petrides M, 2002, P NATL ACAD SCI USA, V99, P5649, DOI 10.1073/pnas.072092299
   RADLOFF L S, 1986, Clinical Gerontologist, V5, P119
   REAVEN GM, 1993, ANNU REV MED, V44, P121, DOI 10.1146/annurev.med.44.1.121
   Reijmer YD, 2011, ATHEROSCLEROSIS, V219, P839, DOI 10.1016/j.atherosclerosis.2011.08.032
   Rothman K J, 1990, Epidemiology, V1, P43, DOI 10.1097/00001648-199001000-00010
   Schneider JA, 2010, STROKE, V41, pS144, DOI 10.1161/STROKEAHA.110.598326
   Segura B, 2009, NEUROSCI LETT, V462, P49, DOI 10.1016/j.neulet.2009.06.071
   Siddiqui S, 2014, DIABETES METAB SYND, V8, P62, DOI 10.1016/j.dsx.2013.06.010
   Silva I, 2013, BEST PRACT RES CL OB, V27, P661, DOI 10.1016/j.bpobgyn.2013.06.005
   Snowdon DA, 1997, JAMA-J AM MED ASSOC, V277, P813, DOI 10.1001/jama.277.10.813
   Squire LR, 2004, NEUROBIOL LEARN MEM, V82, P171, DOI 10.1016/j.nlm.2004.06.005
   SQUIRE LR, 1992, PSYCHOL REV, V99, P195, DOI 10.1037/0033-295X.99.2.195
   Taylor WD, 2013, MOL PSYCHIATR, V18, P963, DOI 10.1038/mp.2013.20
   Tournoy J, 2010, DIABETES-METAB RES, V26, P668, DOI 10.1002/dmrr.1144
   Tsai AC, 2012, J NUTR HEALTH AGING, V16, P492, DOI 10.1007/s12603-012-0025-0
   Vieira JR, 2011, NEUROEPIDEMIOLOGY, V37, P153, DOI 10.1159/000332208
   Villeneuve S, 2011, NEUROPSYCHOLOGIA, V49, P3027, DOI 10.1016/j.neuropsychologia.2011.07.001
   Vogelzangs N, 2007, J GERONTOL A-BIOL, V62, P563, DOI 10.1093/gerona/62.5.563
   Vuorinen M, 2011, DEMENT GERIATR COGN, V31, P119, DOI 10.1159/000323810
   Watari K, 2008, J CLIN EXP NEUROPSYC, V30, P389, DOI 10.1080/13803390701440486
   Watts AS, 2013, J ALZHEIMERS DIS, V35, P253, DOI 10.3233/JAD-121168
   Wechsler D., 1997, Weschsler Memory Scale-III
   Wong RHX, 2014, CURR DIABETES REP, V14, DOI 10.1007/s11892-014-0547-4
   Yates KF, 2012, ARTERIOSCL THROM VAS, V32, P2060, DOI 10.1161/ATVBAHA.112.252759
   Zhang H, 2012, ETHNIC DIS, V22, P308
   Zlokovic BV, 2011, NAT REV NEUROSCI, V12, P723, DOI 10.1038/nrn3114
NR 59
TC 22
Z9 22
U1 0
U2 7
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1567-2050
EI 1875-5828
J9 CURR ALZHEIMER RES
JI Curr. Alzheimer Res.
PY 2015
VL 12
IS 7
BP 640
EP 647
DI 10.2174/1567205012666150701102325
PG 8
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CN9RB
UT WOS:000358785400006
PM 26239040
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Stankiewicz, AJ
   McGowan, EM
   Yu, LL
   Zhdanova, IV
AF Stankiewicz, Alexander J.
   McGowan, Erin M.
   Yu, Lili
   Zhdanova, Irina V.
TI Impaired Sleep, Circadian Rhythms and Neurogenesis in Diet-Induced
   Premature Aging
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE premature aging; circadian; neurogenesis; sleep; high caloric intake;
   cell cycle; scoliosis; anxiety; diurnal vertebrate
ID CALORIC RESTRICTION; ADULT ZEBRAFISH; CARDIOMETABOLIC RISK;
   GLUCOSE-METABOLISM; DENTATE GYRUS; WEIGHT-LOSS; CLOCK GENE; LIFE-SPAN;
   OBESITY; DURATION
AB Chronic high caloric intake (HCI) is a risk factor for multiple major human disorders, from diabetes to neurodegeneration. Mounting evidence suggests a significant contribution of circadian misalignment and sleep alterations to this phenomenon. An inverse temporal relationship between sleep, activity, food intake, and clock mechanisms in nocturnal and diurnal animals suggests that a search for effective therapeutic approaches can benefit from the use of diurnal animal models. Here, we show that, similar to normal aging, HCI leads to the reduction in daily amplitude of expression for core clock genes, a decline in sleep duration, an increase in scoliosis, and anxiety-like behavior. A remarkable decline in adult neurogenesis in 1-year old HCI animals, amounting to only 21% of that in age-matched Control, exceeds age-dependent decline observed in normal 3-year old zebrafish. This is associated with misalignment or reduced amplitude of daily patterns for principal cell cycle regulators, cyclins A and B, and p20, in brain tissue. Together, these data establish HCI in zebrafish as a model for metabolically induced premature aging of sleep, circadian functions, and adult neurogenesis, allowing for a high throughput approach to mechanistic studies and drug trials in a diurnal vertebrate.
C1 [Stankiewicz, Alexander J.; Yu, Lili; Zhdanova, Irina V.] BioChron LLC, Dept Preclin Res & Dev, Worcester, MA 01605 USA.
   [Stankiewicz, Alexander J.; McGowan, Erin M.; Yu, Lili; Zhdanova, Irina V.] Boston Univ, Sch Med, Dept Anat & Neurobiol, Boston, MA 02118 USA.
C3 Boston University
RP Zhdanova, IV (corresponding author), BioChron LLC, Dept Preclin Res & Dev, Worcester, MA 01605 USA.; Zhdanova, IV (corresponding author), Boston Univ, Sch Med, Dept Anat & Neurobiol, Boston, MA 02118 USA.
EM erinmcgowan20@gmail.com; lilifish1964@gmail.com;
   irina.zhdanova@bio-chron.com
OI McGowan, Erin/0000-0003-0054-1555
FU Chaikin-Wile Foundation
FX This work was supported by a grant from the Chaikin-Wile Foundation. We
   authors are grateful to Vickery Trinkaus-Randall (Boston University
   School of Medicine, Boston, MA, USA), Tarik Haydar (Boston University
   School of Medicine, Boston, MA, USA) and Nadine Aziz (Boston University
   School of Medicine, Boston, MA, USA) for help with confocal imaging,
   generous share of the cell counting software, and useful discussions. We
   thank Jason Best (Boston Children's Hospital, Boston, MA, USA), Aga
   Bereznicka (Boston University, Boston, MA, USA), and Christine Cincotta
   (Boston University, Boston, MA, USA) for help with zebrafish maintenance
   and excellent technical assistance.
CR Akinnusi ME, 2012, EUR J INTERN MED, V23, P219, DOI 10.1016/j.ejim.2011.10.016
   Akle V, 2017, J NEUROSCI, V37, P1900, DOI 10.1523/JNEUROSCI.3222-16.2017
   Anson RM, 2003, P NATL ACAD SCI USA, V100, P6216, DOI 10.1073/pnas.1035720100
   Appelbaum L, 2009, P NATL ACAD SCI USA, V106, P21942, DOI 10.1073/pnas.906637106
   Arslan-Ergul A, 2013, AGING DIS, V4, P221
   Ashrafian H, 2013, METAB BRAIN DIS, V28, P341, DOI 10.1007/s11011-013-9412-4
   Barzilai N, 2012, DIABETES, V61, P1315, DOI 10.2337/db11-1300
   Bass J., 2016, CIRCADIAN MECH BIOEN, V132, P144
   Beydoun MA, 2008, AM J CLIN NUTR, V87, P1914, DOI 10.1093/ajcn/87.6.1914
   Bishop NA, 2007, NATURE, V447, P545, DOI 10.1038/nature05904
   Bondolfi L, 2004, NEUROBIOL AGING, V25, P333, DOI 10.1016/S0197-4580(03)00083-6
   Brown CL, 2015, PEDIATR CLIN N AM, V62, P1241, DOI 10.1016/j.pcl.2015.05.013
   Cappuccio FP, 2008, SLEEP, V31, P619, DOI 10.1093/sleep/31.5.619
   Chan JSY, 2013, FRONT AGING NEUROSCI, V5, DOI 10.3389/fnagi.2013.00097
   Chaput JP, 2007, DIABETOLOGIA, V50, P2298, DOI 10.1007/s00125-007-0786-x
   Chen A, 2017, ENEURO, V4, DOI 10.1523/ENEURO.0286-16.2017
   Corella D, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-015-0327-8
   Dashti HS, 2015, ADV NUTR, V6, P648, DOI 10.3945/an.115.008623
   Drager LF, 2013, J AM COLL CARDIOL, V62, P569, DOI 10.1016/j.jacc.2013.05.045
   Egan RJ, 2009, BEHAV BRAIN RES, V205, P38, DOI 10.1016/j.bbr.2009.06.022
   Elbaz I., 2016, MOL NEUROBIOL, DOI [10.1007/s12035-016-0175-x27734337, DOI 10.1007/S12035-016-0175-X27734337]
   Elbaz I, 2017, CURR TOP BEHAV NEURO, V33, P75, DOI 10.1007/7854_2016_59
   Garaulet M, 2014, MOL NUTR FOOD RES, V58, P821, DOI 10.1002/mnfr.201300361
   Gerhard GS, 2002, EXP GERONTOL, V37, P1055, DOI 10.1016/S0531-5565(02)00088-8
   Gilbert MJH, 2014, EXP GERONTOL, V50, P106, DOI 10.1016/j.exger.2013.11.013
   Grandel H, 2006, DEV BIOL, V295, P263, DOI 10.1016/j.ydbio.2006.03.040
   Guh DP, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-88
   Gurnani M, 2015, PEDIATR CLIN N AM, V62, P821, DOI 10.1016/j.pcl.2015.04.001
   Hirayama J, 2005, METHOD ENZYMOL, V393, P186, DOI 10.1016/S0076-6879(05)93005-X
   Hood S, 2017, FRONT AGING NEUROSCI, V9, DOI 10.3389/fnagi.2017.00170
   Jensen MD, 2014, CIRCULATION, V129, pS102, DOI 10.1161/01.cir.0000437739.71477.ee
   Jha PK, 2015, MOL CELL ENDOCRINOL, V418, P74, DOI 10.1016/j.mce.2015.01.024
   Kacprzak V., 2017, PHARM BIOCH BEHAV, V1, P53, DOI [10.1016/j.pbb.2017.01.00528408289, DOI 10.1016/J.PBB.2017.01.00528408289]
   Katewa SD, 2016, CELL METAB, V23, P143, DOI 10.1016/j.cmet.2015.10.014
   Keckeis M, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009444
   Kishi S, 2009, GERONTOLOGY, V55, P430, DOI 10.1159/000228892
   Kishi S, 2008, PLOS GENET, V4, DOI 10.1371/journal.pgen.1000152
   Knutson KL, 2011, DIABETES CARE, V34, P1171, DOI 10.2337/dc10-1962
   Knutson KL, 2010, BEST PRACT RES CL EN, V24, P731, DOI 10.1016/j.beem.2010.07.001
   Kumar S, 2009, NEUROSCI RES, V65, P367, DOI 10.1016/j.neures.2009.08.015
   Lee J, 2002, J NEUROCHEM, V82, P1367, DOI 10.1046/j.1471-4159.2002.01085.x
   Lee J, 2002, J NEUROCHEM, V80, P539, DOI 10.1046/j.0022-3042.2001.00747.x
   Lee J, 2000, J MOL NEUROSCI, V15, P99, DOI 10.1385/JMN:15:2:99
   Levin ED, 2007, PHYSIOL BEHAV, V90, P54, DOI 10.1016/j.physbeh.2006.08.026
   Levitas-Djerbi T, 2017, CURR OPIN NEUROBIOL, V44, P89, DOI 10.1016/j.conb.2017.02.017
   Lindqvist A, 2006, EUR J NEUROL, V13, P1385, DOI 10.1111/j.1468-1331.2006.01500.x
   Longo VD, 2016, CELL METAB, V23, P1048, DOI 10.1016/j.cmet.2016.06.001
   López-Patiño MA, 2008, PHYSIOL BEHAV, V93, P160, DOI 10.1016/j.physbeh.2007.08.013
   Mander BA, 2017, NEURON, V94, P19, DOI 10.1016/j.neuron.2017.02.004
   Maury E, 2014, DIABETES METAB, V40, P338, DOI 10.1016/j.diabet.2013.12.005
   Minireview Etienne C., 2007, ENDOCRINOLOGY, V148, P5648
   Mitchell NS, 2011, PSYCHIAT CLIN N AM, V34, P717, DOI 10.1016/j.psc.2011.08.005
   Nedeltcheva AV, 2014, CURR OPIN ENDOCRINOL, V21, P293, DOI 10.1097/MED.0000000000000082
   Oikonomou G, 2017, CURR OPIN NEUROBIOL, V44, P80, DOI 10.1016/j.conb.2017.03.009
   Patel SR, 2008, OBESITY, V16, P643, DOI 10.1038/oby.2007.118
   Patel SA, 2016, FASEB J, V30, P1634, DOI 10.1096/fj.15-282475
   Poirier P, 2006, CIRCULATION, V113, P898, DOI 10.1161/CIRCULATIONAHA.106.171016
   PRAKASH YS, 1994, NEUROIMAGE, V1, P325, DOI 10.1006/nimg.1994.1017
   Procaccini C, 2016, METABOLISM, V65, P1376, DOI [10.1016/j.metabol, 10.1016/j.metabol.2016.05.018]
   Rudic RD, 2004, PLOS BIOL, V2, P1893, DOI 10.1371/journal.pbio.0020377
   Sato S, 2017, CELL, V170, P664, DOI 10.1016/j.cell.2017.07.042
   Scott EM, 2008, INT J OBESITY, V32, P658, DOI 10.1038/sj.ijo.0803778
   Sohal RS, 1996, SCIENCE, V273, P59, DOI 10.1126/science.273.5271.59
   Sookoian S, 2008, AM J CLIN NUTR, V87, P1606, DOI 10.1093/ajcn/87.6.1606
   Spence R, 2008, BIOL REV, V83, P13, DOI 10.1111/j.1469-185X.2007.00030.x
   Spiegel K, 2005, J APPL PHYSIOL, V99, P2008, DOI 10.1152/japplphysiol.00660.2005
   Stangl D, 2009, GENES NUTR, V4, P271, DOI 10.1007/s12263-009-0134-5
   Stewart A, 2012, NEUROPHARMACOLOGY, V62, P135, DOI 10.1016/j.neuropharm.2011.07.037
   Tamai TK, 2005, BIOCHEM SOC T, V33, P962, DOI 10.1042/BST0330962
   Thorpe RJ, 2004, RES AGING, V26, P108, DOI 10.1177/0164027503258738
   Tsai SB, 2007, AGING CELL, V6, P209, DOI 10.1111/j.1474-9726.2007.00278.x
   Turek FW, 2005, SCIENCE, V308, P1043, DOI 10.1126/science.1108750
   Uemura H, 2016, J DIABETES, V8, P667, DOI 10.1111/1753-0407.12344
   Vauzour D., 2017, RES REV, V35, P222, DOI [10.1016/j.arr.2016.09.01027713095, DOI 10.1016/J.ARR.2016.09.01027713095]
   Whitmer RA, 2008, NEUROLOGY, V71, P1057, DOI 10.1212/01.wnl.0000306313.89165.ef
   Whitmore D, 2000, NATURE, V404, P87, DOI 10.1038/35003589
   Yaturu Subhashini., 2011, J DIABETES MELLITUS, V1, P79
   Yokogawa T, 2007, PLOS BIOL, V5, P2379, DOI 10.1371/journal.pbio.0050277
   Yu LL, 2006, PLOS ONE, V1, DOI 10.1371/journal.pone.0000014
   Zeng CB, 2010, BRAIN RES, V1319, P21, DOI 10.1016/j.brainres.2009.12.092
   Zhdanova IV, 2008, BRAIN RES BULL, V75, P433, DOI 10.1016/j.brainresbull.2007.10.053
   Zhdanova IV, 2006, ZEBRAFISH, V3, P215, DOI 10.1089/zeb.2006.3.215
   Zhdanova IV, 2001, BRAIN RES, V903, P263, DOI 10.1016/S0006-8993(01)02444-1
   Zupanc GKH, 2005, J COMP NEUROL, V488, P290, DOI 10.1002/cne.20571
NR 84
TC 18
Z9 19
U1 1
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD NOV
PY 2017
VL 18
IS 11
AR 2243
DI 10.3390/ijms18112243
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA FO4KK
UT WOS:000416811300017
PM 29072584
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Poteat, T
   Gallo, LC
   Harkness, A
   Isasi, CR
   Matthews, P
   Schneiderman, N
   Thyagarajan, B
   Daviglus, ML
   Sotres-Alvarez, D
   Perreira, KM
AF Poteat, Tonia
   Gallo, Linda C.
   Harkness, Audrey
   Isasi, Carmen R.
   Matthews, Phoenix
   Schneiderman, Neil
   Thyagarajan, Bharat
   Daviglus, Martha L.
   Sotres-Alvarez, Daniela
   Perreira, Krista M.
TI Influence of Stress, Gender, and Minority Status on Cardiovascular
   Disease Risk in the Hispanic/Latino Community: Protocol for a
   Longitudinal Observational Cohort Study
SO JMIR RESEARCH PROTOCOLS
LA English
DT Article
DE minority stress; cardiovascular disease; sexual and gender minorities;
   transgender; intersex; lesbian; bisexual; gay; Hispanic; Latino
ID SEXUAL ORIENTATION; METABOLIC SYNDROME; PERCEIVED DISCRIMINATION;
   HEALTH-STATUS; MYOCARDIAL-INFARCTION; MENTAL-HEALTH; 52 COUNTRIES;
   ADULTS; HISPANICS/LATINOS; PREVALENCE
AB Background: Hispanic/Latino sexual and gender minorities (SGM) are the fastest growing ethnic group of SGM in the United States. Cardiovascular disease (CVD) is a leading cause of morbidity and mortality among Hispanics/Latinos. SGM inequities in CVD risk have been identified as early as young adulthood, and minority stress has been identified as a potential mediator. Yet, the small number of ethnic or racial minority participants in SGM studies have precluded the examination of the intersections of sexual orientation, gender identity, and race and ethnicity.
   Objective: Minority stress models conceptualize relationships between stressors in minority groups and health outcomes. In this study, we will (1) examine the influence of sexual orientation and gender identity on CVD risk among all Hispanic Community Health Study/Study of Latinos (HCHS/SOL) participants at visit 3 (2021-2024; N similar to 9300); (2) model pathways from sexual orientation and gender identity to CVD risk through stigma, discrimination, and stress in a 1:2 matched subcohort of SGM and non-SGM participants at visit 3 (n similar to 1680); and (3) examine the influence of resilience factors on sexual orientation or gender identity and CVD risk relationships among subcohort participants at visit 3 (n similar to 1680).
   Methods: This study will leverage existing data from the parent HCHS/SOL study (collected since 2008) while collecting new data on sexual orientation, gender identity, stigma, discrimination, stress, coping, social support, and CVD risk. Data analysis will follow the SGM minority stress model, which states that excess stigma against SGM populations leads to minority stress that increases CVD risk. In this model, coping and social support serve as resilience factors that can mitigate the impact of minority stress on CVD risk. Cross-sectional and longitudinal regression models as well as structural equation models will be used to test these relationships.
   Results: This study was funded by the National Heart, Lung, and Blood Institute in March 2020. Recruitment is scheduled to begin in the first quarter of 2021 and continue through 2024.
   Conclusions: Understanding the influence of stigma-induced stress on CVD risk among Hispanic/Latino SGM has significant implications for the development of culturally specific CVD risk reduction strategies. Study findings will be used to build on identified Hispanic/Latino cultural strengths to inform adaptation and testing of family and community acceptance interventions.
C1 [Poteat, Tonia; Perreira, Krista M.] Univ N Carolina, Sch Med, Dept Social Med, MacNider Hall,333 South Columbia St,Room 345B, Chapel Hill, NC 27599 USA.
   [Gallo, Linda C.] San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA.
   [Harkness, Audrey] Univ Miami, Dept Publ Hlth Sci, Miami, FL USA.
   [Isasi, Carmen R.] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, New York, NY USA.
   [Matthews, Phoenix] Univ Illinois, Dept Populat Hlth Nursing Sci, Chicago, IL USA.
   [Schneiderman, Neil] Univ Miami, Dept Psychol, Miami, FL USA.
   [Thyagarajan, Bharat] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA.
   [Daviglus, Martha L.] Univ Illinois, Coll Med, Inst Minor Hlth Res, Chicago, IL USA.
   [Sotres-Alvarez, Daniela] Univ N Carolina, Dept Biostat, Chapel Hill, NC 27599 USA.
C3 University of North Carolina School of Medicine; University of North
   Carolina; University of North Carolina Chapel Hill; California State
   University System; San Diego State University; University of Miami;
   Yeshiva University; University of Illinois System; University of
   Illinois Chicago; University of Illinois Chicago Hospital; University of
   Miami; University of Minnesota System; University of Minnesota Twin
   Cities; University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of North Carolina;
   University of North Carolina Chapel Hill
RP Poteat, T (corresponding author), Univ N Carolina, Sch Med, Dept Social Med, MacNider Hall,333 South Columbia St,Room 345B, Chapel Hill, NC 27599 USA.
EM tonia.poteat@med.unc.edu
RI Sotres-Alvarez, Daniela/O-9085-2016; Harkness, Audrey/ABG-1920-2021;
   Matthews, Alicia/R-4704-2018
OI Matthews, Alicia/0000-0002-0074-681X; Thyagarajan,
   Bharat/0000-0001-6968-6985; Gallo, Linda C./0000-0002-3678-5888; Isasi,
   Carmen R/0000-0003-2700-9593; Schneiderman, Neil/0000-0002-7982-068X;
   Perreira, Krista/0000-0003-2906-0261; Harkness,
   Audrey/0000-0003-2290-9904; Poteat, Tonia/0000-0001-6541-3787
FU National Heart Blood and Lung Institute [R01HL149778]; National Heart,
   Lung, and Blood Institute (NHLBI) [HHSN268201300001I/N01HC65233,
   HHSN268201300004I/N01HC65234, HHSN268201300002I/N01HC65235,
   HHSN268201300003I/N01-HC-65236, HHSN268201300005I/N01HC65237]; National
   Institute on Minority Health and Health Disparities; National Institute
   on Deafness and Other Communication Disorders; National Institute of
   Dental and Craniofacial Research; National Institute of Diabetes and
   Digestive and Kidney Diseases; National Institute of Neurological
   Disorders and Stroke; NIH Office of Dietary Supplements
FX The authors thank the staff and participants of HCHS/SOL for their
   important contributions. A complete list of baseline staff and
   investigators has been provided by Sorlie et al [38] and is also
   available on the study website [87,88] . SGM SOL has been funded by the
   National Heart Blood and Lung Institute (R01HL149778) . HCHS/SOL is a
   collaborative study supported by contracts from the National Heart,
   Lung, and Blood Institute (NHLBI) to the University of North Carolina
   (HHSN268201300001I/N01HC65233) , University of Miami
   (HHSN268201300004I/N01HC65234) , Albert Einstein College of Medicine
   (HHSN268201300002I/N01HC65235) , University of Illinois at Chicago
   (HHSN268201300003I/N01-HC-65236 Northwestern Univ) , and San Diego State
   University (HHSN268201300005I/N01HC65237) . The following institutes,
   centers, and offices have contributed to HCHS/SOL through a transfer of
   funds to the NHLBI: National Institute on Minority Health and Health
   Disparities, National Institute on Deafness and Other Communication
   Disorders, National Institute of Dental and Craniofacial Research,
   National Institute of Diabetes and Digestive and Kidney Diseases,
   National Institute of Neurological Disorders and Stroke, and NIH Office
   of Dietary Supplements.
CR Abraído-Lanza AF, 1999, AM J PUBLIC HEALTH, V89, P1543, DOI 10.2105/AJPH.89.10.1543
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   [Anonymous], 2019, SEXUAL GENDER MINORI
   [Anonymous], 2009, Best practices for asking questions about sexual orientation on surveys
   [Anonymous], 2016, Evaluations of sexual orientation and gender identity survey measures: What have we learned?
   [Anonymous], 2020, National Public Radio
   [Anonymous], 2020, HISPANIC COMMUNITY H
   Arellano-Morales L, 2015, J LAT O PSYCHOL, V3, P160, DOI 10.1037/lat0000040
   Arguelles W, 2015, INT J CARDIOL, V184, P373, DOI 10.1016/j.ijcard.2015.02.100
   Badgett M.V. L., 2014, Best Practices for asking questions to identify transgender and other gender minority respondents on population -based surveys
   Balfour PC, 2016, J LAT O PSYCHOL, V4, P98, DOI 10.1037/lat0000056
   Balsam KF, 2011, CULT DIVERS ETHN MIN, V17, P163, DOI 10.1037/a0023244
   Bauer GR, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0178043
   Beckie TM, 2012, BIOL RES NURS, V14, P311, DOI 10.1177/1099800412455688
   Bieler GS, 2010, AM J EPIDEMIOL, V171, P618, DOI 10.1093/aje/kwp440
   Bowleg L, 2012, AM J PUBLIC HEALTH, V102, P1267, DOI 10.2105/AJPH.2012.300750
   Bromberger JT, 1996, PSYCHOL AGING, V11, P207, DOI 10.1037/0882-7974.11.2.207
   Caceres BA, 2020, CIRCULATION, V142, pE321, DOI 10.1161/CIR.0000000000000914
   Caceres BA, 2018, LGBT HEALTH, V5, P284, DOI 10.1089/lgbt.2017.0220
   Castañeda SF, 2016, PREV MED, V87, P144, DOI 10.1016/j.ypmed.2016.02.032
   Cho S, 2013, SIGNS, V38, P785, DOI 10.1086/669608
   Cunningham TJ, 2018, MMWR-MORBID MORTAL W, V67, P888, DOI 10.15585/mmwr.mm6732a4
   Daviglus ML, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.116.003929
   Daviglus ML, 2012, JAMA-J AM MED ASSOC, V308, P1775, DOI 10.1001/jama.2012.14517
   Frost DM, 2015, J BEHAV MED, V38, P1, DOI 10.1007/s10865-013-9523-8
   Gallo LC, 2014, PSYCHOSOM MED, V76, P468, DOI 10.1097/PSY.0000000000000069
   Gallo LC, 2009, J PERS, V77, P1707, DOI 10.1111/j.1467-6494.2009.00598.x
   Gates G.J., 2011, WILLIAMS I UCLA SCH
   Gil AG, 1996, J SOC PERS RELAT, V13, P435, DOI 10.1177/0265407596133008
   Goff DC Jr, 2014, J AM COLL CARDIOL, V63, P2935, DOI 10.1016/j.jacc.2013.11.005
   Gonzales G, 2017, J COMMUN HEALTH, V42, P1163, DOI 10.1007/s10900-017-0366-z
   Gonzales G, 2016, JAMA INTERN MED, V176, P1344, DOI 10.1001/jamainternmed.2016.3432
   Gray NN, 2015, AM J COMMUN PSYCHOL, V55, P202, DOI 10.1007/s10464-014-9697-4
   Hatzenbuehler ML, 2016, PEDIATR CLIN N AM, V63, P985, DOI 10.1016/j.pcl.2016.07.003
   Hatzenbuehler ML, 2014, HEALTH PSYCHOL, V33, P1185, DOI 10.1037/hea0000126
   Hatzenbuehler ML, 2013, AM J PREV MED, V44, P612, DOI 10.1016/j.amepre.2013.01.027
   Hatzenbuehler ML, 2013, AM J PUBLIC HEALTH, V103, P813, DOI 10.2105/AJPH.2012.301069
   Hausmann LRM, 2008, MED CARE, V46, P905, DOI 10.1097/MLR.0b013e3181792562
   Heiss G, 2014, DIABETES CARE, V37, P2391, DOI 10.2337/dc13-2505
   Isasi CR, 2015, ANN EPIDEMIOL, V25, P84, DOI 10.1016/j.annepidem.2014.11.002
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jones CP, 2008, ETHNIC DIS, V18, P496
   Kaplan RC, 2014, AM J PREV MED, V46, P496, DOI 10.1016/j.amepre.2014.01.014
   Krieger N, 1999, INT J HEALTH SERV, V29, P295, DOI 10.2190/M11W-VWXE-KQM9-G97Q
   Lagos D, 2018, DEMOGRAPHY, V55, P2097, DOI 10.1007/s13524-018-0714-3
   Lavange LM, 2010, ANN EPIDEMIOL, V20, P642, DOI 10.1016/j.annepidem.2010.05.006
   Lee MA, 2009, SOC SCI MED, V68, P1966, DOI 10.1016/j.socscimed.2009.02.052
   López N, 2018, SOCIOL RACE ETHNIC, V4, P49, DOI 10.1177/2332649217708798
   Maneesriwongul W, 2004, J ADV NURS, V48, P175, DOI 10.1111/j.1365-2648.2004.03185.x
   McConnell Elizabeth A, 2018, Psychol Sex Orientat Gend Divers, V5, P1, DOI 10.1037/sgd0000265
   Merz EL, 2016, J LAT O PSYCHOL, V4, P131, DOI 10.1037/lat0000047
   Merz EL, 2014, PSYCHOL ASSESSMENT, V26, P384, DOI 10.1037/a0035248
   Meyer IH, 2003, PSYCHOL BULL, V129, P674, DOI 10.1037/0033-2909.129.5.674
   Meyer IH, 2008, SOC SCI MED, V67, P368, DOI 10.1016/j.socscimed.2008.03.012
   Meyer IH, 2017, AM J PUBLIC HEALTH, V107, P582, DOI 10.2105/AJPH.2016.303648
   Michaels S, 2017, LGBT HEALTH, V4, P412, DOI 10.1089/lgbt.2016.0168
   Muntner P, 2014, JAMA-J AM MED ASSOC, V311, P1406, DOI 10.1001/jama.2014.2630
   Ouellette Tammy., 2004, MEASURES MAT HARDSHI
   Outland P.L., 2016, Developing the LGBT Minority Stress Measure
   Pascoe EA, 2009, PSYCHOL BULL, V135, P531, DOI 10.1037/a0016059
   Patterson C.J., 2020, Understanding the well-being of LGBTQI+ pop ulations, DOI DOI 10.17226/25877
   Penedo FJ, 2015, ANN BEHAV MED, V49, P793, DOI 10.1007/s12160-015-9713-4
   Reisner SL, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-1224
   Reisner SL, 2014, ARCH SEX BEHAV, V43, P1503, DOI 10.1007/s10508-014-0314-2
   Ridolfo H, 2012, SEX RES SOC POLICY, V9, P113, DOI 10.1007/s13178-011-0074-x
   Roberts RE, 1999, J EARLY ADOLESCENCE, V19, P301, DOI 10.1177/0272431699019003001
   Rodriguez N, 2017, J AGING HEALTH, V29, P986, DOI 10.1177/0898264317710839
   Rosengren A, 2004, LANCET, V364, P953, DOI 10.1016/S0140-6736(04)17019-0
   Ruiz JM, 2016, J LAT O PSYCHOL, V4, P61, DOI 10.1037/lat0000065
   Ryan C, 2010, J CHILD ADOL PS NURS, V23, P205, DOI 10.1111/j.1744-6171.2010.00246.x
   Sánchez JP, 2014, LGBT HEALTH, V1, P161, DOI 10.1089/lgbt.2014.0034
   Schneiderman N, 2014, PROG CARDIOVASC DIS, V57, P253, DOI 10.1016/j.pcad.2014.08.004
   Seeman T, 2010, ANN NY ACAD SCI, V1186, P223, DOI 10.1111/j.1749-6632.2009.05341.x
   Sinclair VG, 2004, ASSESSMENT, V11, P94, DOI 10.1177/1073191103258144
   Sorlie PD, 2010, ANN EPIDEMIOL, V20, P629, DOI 10.1016/j.annepidem.2010.03.015
   Sternthal MJ, 2011, DU BOIS REV, V8, P95, DOI 10.1017/S1742058X11000087
   Tamar-Mattis S, 2018, LGBT HEALTH, V5, P320, DOI 10.1089/lgbt.2017.0180
   Testa RJ., 2015, Psychology of Sexual Orientation and Gender Diversity, V2, P65, DOI [10.1037/sgd0000081, DOI 10.1037/SGD0000081]
   Thoemmes F, 2010, STRUCT EQU MODELING, V17, P510, DOI 10.1080/10705511.2010.489379
   Topel ML, 2018, AM J CARDIOL, V121, P564, DOI 10.1016/j.amjcard.2017.11.031
   Valdiserri RO, 2019, J HOMOSEXUAL, V66, P571, DOI 10.1080/00918369.2017.1422944
   Vásquez E, 2016, J PHYS ACT HEALTH, V13, P310, DOI 10.1123/jpah.2014-0608
   Williams D R, 1997, J Health Psychol, V2, P335, DOI 10.1177/135910539700200305
   Worthen MGF, 2018, J SEX RES, V55, P995, DOI 10.1080/00224499.2017.1378309
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
NR 85
TC 7
Z9 8
U1 1
U2 10
PU JMIR PUBLICATIONS, INC
PI TORONTO
PA 130 QUEENS QUAY E, STE 1102, TORONTO, ON M5A 0P6, CANADA
SN 1929-0748
J9 JMIR RES PROTOC
JI JMIR RES. Protoc.
PD MAY
PY 2021
VL 10
IS 5
AR e28997
DI 10.2196/28997
PG 15
WC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
WE Emerging Sources Citation Index (ESCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA SN4JJ
UT WOS:000658257400033
PM 33955843
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Roshanravan, N
   Ghaffari, S
AF Roshanravan, Neda
   Ghaffari, Samad
TI The therapeutic potential of Crocus sativus Linn.: A
   comprehensive narrative review of clinical trials
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE anti-inflammatory; antioxidant; Crocus sativus Linn; saffron
ID PERSISTENT ALLERGIC-ASTHMA; MAJOR DEPRESSIVE DISORDER; DOUBLE-BLIND;
   SAFFRON SUPPLEMENTATION; METABOLIC SYNDROME; PREMENSTRUAL-SYNDROME;
   OXIDATIVE STRESS; TRIPLE-BLIND; L. SAFFRON; ANTIINFLAMMATORY PROPERTIES
AB Crocus sativus Linn. (Saffron) is valued worldwide for its potential use in the management of various degenerative disorders, including cardiovascular diseases (CVDs), diabetes, cancer, metabolic syndrome (MetS), neurodegenerative diseases, immune disorders, and sexual dysfunction. Previous reports, based on clinical trials, suggest that crocetin, crocin, picrocrocin, and safranal are the main bioactive components of saffron with antioxidant, anti-inflammatory, and anti-apoptotic effects. In this comprehensive narrative review, we studied the recent clinical trials, investigating the medicinal applications of saffron and/or its components. The present results can provide important insights into the potential of saffron in preventing and treating different disorders, with a special focus on the underlying cellular and molecular mechanisms. However, further high-quality studies are needed to firmly establish the clinical efficacy of saffron in treating some degenerative diseases.
C1 [Roshanravan, Neda; Ghaffari, Samad] Tabriz Univ Med Sci, Cardiovasc Res Ctr, Tabriz, Iran.
C3 Tabriz University of Medical Science
RP Roshanravan, N; Ghaffari, S (corresponding author), Tabriz Univ Med Sci, Cardiovasc Res Ctr, Tabriz, Iran.
EM neda.roshanravan10@gmail.com; ghafaris@gmail.com
OI Ghaffari, Samad/0000-0001-6806-9387
CR Abdullaev FI, 2004, CANCER DETECT PREV, V28, P426, DOI 10.1016/j.cdp.2004.09.002
   ABDULLAEV FI, 1992, BIOFACTORS, V3, P201
   Abedimanesh N, 2017, J CARDIOVASC THORAC, V9, P200, DOI 10.15171/jcvtr.2017.35
   Agha-Hosseini M, 2008, BJOG-INT J OBSTET GY, V115, P515, DOI 10.1111/j.1471-0528.2007.01652.x
   Ahmadpanah M, 2019, PSYCHIAT RES, V282, DOI 10.1016/j.psychres.2019.112613
   Ahrazem O, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-21225-z
   Akbari-Fakhrabadi M, 2019, J FOOD BIOCHEM, V43, DOI 10.1111/jfbc.12946
   Akhondzadeh Shahin, 2004, BMC Complement Altern Med, V4, P12, DOI 10.1186/1472-6882-4-12
   Aleali AM, 2019, PHYTOTHER RES, V33, P1648, DOI 10.1002/ptr.6351
   Almodóvar P, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/1575730
   Altinoz E, 2015, HUM EXP TOXICOL, V34, P127, DOI 10.1177/0960327114538989
   Amin A, 2011, HEPATOLOGY, V54, P857, DOI 10.1002/hep.24433
   Andres S, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700447
   Ashtiani Alireza Rezaee, 2020, Journal of Basic and Clinical Physiology and Pharmacology, V31, P20200063, DOI [10.1515/JBCPP-2020-0063, 10.1515/jbcpp-2020-0063]
   Assimopoulou AN, 2005, PHYTOTHER RES, V19, P997, DOI 10.1002/ptr.1749
   Avasthi A, 2017, INDIAN J PSYCHIAT, V59, pS91, DOI 10.4103/0019-5545.196977
   Azimi Paria, 2014, Rev Diabet Stud, V11, P258, DOI 10.1900/RDS.2014.11.258
   Balakumar P, 2016, PHARMACOL RES, V113, P600, DOI 10.1016/j.phrs.2016.09.040
   Basti AA, 2007, PROG NEURO-PSYCHOPH, V31, P439, DOI 10.1016/j.pnpbp.2006.11.010
   Bateman ED, 2008, EUR RESPIR J, V31, P143, DOI 10.1183/09031936.00138707
   Bathaie SZ, 2014, BIOTECH HISTOCHEM, V89, P401, DOI 10.3109/10520295.2014.890741
   Bathaie SZ, 2010, CRIT REV FOOD SCI, V50, P761, DOI 10.1080/10408390902773003
   Baziar S, 2019, J CHILD ADOL PSYCHOP, V29, P205, DOI 10.1089/cap.2018.0146
   Beiranyand SP, 2016, EUR J INTEGR MED, V8, P55, DOI 10.1016/j.eujim.2015.06.003
   Bickers DR, 2006, J INVEST DERMATOL, V126, P2565, DOI 10.1038/sj.jid.5700340
   Bonyadi MHJ, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-399
   Boskabady MH, 2016, PHYTOTHER RES, V30, P1072, DOI 10.1002/ptr.5622
   Bostan HB, 2017, IRAN J BASIC MED SCI, V20, P110, DOI 10.22038/ijbms.2017.8230
   Broadhead GK, 2019, GRAEF ARCH CLIN EXP, V257, P31, DOI 10.1007/s00417-018-4163-x
   Bukhari SI, 2018, BIOMED PHARMACOTHER, V98, P733, DOI 10.1016/j.biopha.2017.12.090
   Bukhari SI, 2015, PHYTOTHER RES, V29, P617, DOI 10.1002/ptr.5315
   Christodoulou E, 2015, J PHARM PHARMACOL, V67, P1634, DOI 10.1111/jphp.12456
   Colapietro A, 2019, ANTI-CANCER AGENT ME, V19, P38, DOI 10.2174/1871520619666181231112453
   Das I, 2010, ACTA HISTOCHEM, V112, P317, DOI 10.1016/j.acthis.2009.02.003
   DUGGER BN, 2017, CSH PERSPECT BIOL, V9, DOI DOI 10.1101/CSHPERSPECT.A028035
   DuPont MS, 2004, EUR J CLIN NUTR, V58, P947, DOI 10.1038/sj.ejcn.1601916
   Duval C, 2007, BBA-MOL CELL BIOL L, V1771, P961, DOI 10.1016/j.bbalip.2007.05.003
   Ebrahimi F, 2019, DIABETES METAB SYNDR, V12, P2107, DOI 10.2147/DMSO.S216666
   Esposito E, 2019, CURR PHARM DESIGN, V25, P2323, DOI 10.2174/1381612825666190709210703
   Fadai F, 2014, PHARMACOPSYCHIATRY, V47, P156, DOI 10.1055/s-0034-1382001
   Falsini B, 2010, INVEST OPHTH VIS SCI, V51, P6118, DOI 10.1167/iovs.09-4995
   Feyzi R, 2016, IRAN J IMMUNOL, V13, P263, DOI IJIv13i4A3
   Fiorilli V, 2019, FRONT PLANT SCI, V10, DOI 10.3389/fpls.2019.01186
   Fukui H, 2011, PHYTOMEDICINE, V18, P726, DOI 10.1016/j.phymed.2010.11.013
   Georgiadou G, 2012, NEUROSCI LETT, V528, P27, DOI 10.1016/j.neulet.2012.08.081
   Ghaderi A, 2020, COMPLEMENT THER MED, V48, DOI 10.1016/j.ctim.2019.102250
   Ghaffari S, 2019, BIOMED PHARMACOTHER, V109, P21, DOI 10.1016/j.biopha.2018.10.031
   Ghajar A, 2017, PHARMACOPSYCHIATRY, V50, P152, DOI 10.1055/s-0042-116159
   Giaccio M, 2004, CRIT REV FOOD SCI, V44, P155, DOI 10.1080/10408690490441433
   Giannoulaki P, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051424
   Golmohammadzadeh S, 2010, IRAN J PHARM RES, V9, P133
   Gottesmann C, 2002, NEUROSCIENCE, V111, P231, DOI 10.1016/S0306-4522(02)00034-9
   Gout B, 2010, NUTR RES, V30, P305, DOI 10.1016/j.nutres.2010.04.008
   Hatziagapiou K, 2019, CURR NEUROPHARMACOL, V17, P377, DOI 10.2174/1570159X16666180321095705
   Hausenblas HA, 2015, J INTEGR MED-JIM, V13, P231, DOI 10.1016/S2095-4964(15)60176-5
   He SY, 2007, EUR J PHARMACOL, V554, P191, DOI 10.1016/j.ejphar.2006.09.071
   Heitmar R, 2019, NUTRIENTS, V11, DOI 10.3390/nu11030649
   Hosseini A, 2018, IRAN J BASIC MED SCI, V21, P1091, DOI 10.22038/IJBMS.2018.31243.7529
   Hosseini SA, 2018, RESP MED, V145, P28, DOI 10.1016/j.rmed.2018.10.016
   Hosseinzadeh H, 2005, J PHARM PHARM SCI, V8, P387
   Hosseinzadeh H, 2005, FITOTERAPIA, V76, P722, DOI 10.1016/j.fitote.2005.07.008
   Hosseinzadeh H, 2004, ACTA HORTIC, P435, DOI 10.17660/ActaHortic.2004.650.54
   Hosseinzadeh H, 2013, IRAN J PHARM RES, V12, P93
   Hosseinzadeh H, 2009, PHARMACOGN MAG, V5, P419
   Izzo AA, 2020, BRIT J PHARMACOL, V177, P2169, DOI 10.1111/bph.15054
   Jam IN, 2017, ADV CLIN EXP MED, V26, P925, DOI 10.17219/acem/62891
   Javandoost A, 2017, ARYA ATHEROSCLER, V13, P245
   Bagur MJ, 2018, MOLECULES, V23, DOI 10.3390/molecules23010030
   Kang C, 2012, FOOD CHEM, V135, P2350, DOI 10.1016/j.foodchem.2012.06.092
   Karimi-Nazari E, 2019, CLIN NUTR ESPEN, V34, P130, DOI 10.1016/j.clnesp.2019.07.012
   Kashani L, 2018, ARCH GYNECOL OBSTET, V297, P717, DOI 10.1007/s00404-018-4655-2
   Kashani L, 2013, HUM PSYCHOPHARM CLIN, V28, P54, DOI 10.1002/hup.2282
   Kell G, 2017, COMPLEMENT THER MED, V33, P58, DOI 10.1016/j.ctim.2017.06.001
   Kermani T, 2017, J RES PHARM PRACT, V6, P228, DOI 10.4103/jrpp.JRPP_17_26
   Kermani T, 2015, AVICENNA J PHYTOMEDI, V5, P427
   Khatami M, 2009, CELL BIOCHEM BIOPHYS, V55, P55, DOI 10.1007/s12013-009-9059-2
   Khazdair MR, 2015, AVICENNA J PHYTOMEDI, V5, P376
   Khori V, 2012, PHYTOTHER RES, V26, P826, DOI 10.1002/ptr.3643
   Kianbakht S, 2011, PHYTOTHER RES, V25, P1801, DOI 10.1002/ptr.3484
   Kyriakoudi A, 2013, J AGR FOOD CHEM, V61, P5318, DOI 10.1021/jf400540y
   Lashay Alireza, 2016, Med Hypothesis Discov Innov Ophthalmol, V5, P32
   Lautenschläger M, 2015, PHYTOMEDICINE, V22, P36, DOI 10.1016/j.phymed.2014.10.009
   Leone Sheila, 2018, Phytother Res, V32, P2364, DOI 10.1002/ptr.6181
   Li CY, 2002, CHEM PHARM BULL, V50, P1305, DOI 10.1248/cpb.50.1305
   Li Y, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030167
   Lopresti AL, 2020, J CLIN SLEEP MED, V16, P937, DOI 10.5664/jcsm.8376
   Lopresti AL, 2018, J AFFECT DISORDERS, V232, P349, DOI 10.1016/j.jad.2018.02.070
   Lopresti AL, 2014, HUM PSYCHOPHARM CLIN, V29, P517, DOI 10.1002/hup.2434
   Lu MW, 2018, FOOD FUNCT, V9, P4569, DOI 10.1039/c8fo01349g
   Lv BC, 2016, INT J MOL MED, V37, P225, DOI 10.3892/ijmm.2015.2418
   Magesh V, 2006, MOL CELL BIOCHEM, V287, P127, DOI 10.1007/s11010-005-9088-0
   Mahdizadeh S, 2016, DARU, V24, DOI 10.1186/s40199-016-0155-8
   Maleki-Saghooni N, 2018, AVICENNA J PHYTOMEDI, V8, P96
   Marangoni D, 2013, J TRANSL MED, V11, DOI 10.1186/1479-5876-11-228
   Mashmoul M, 2013, ANTIOXIDANTS-BASEL, V2, P293, DOI 10.3390/antiox2040293
   Mazidi Mohsen, 2016, J Complement Integr Med, V13, P195, DOI 10.1515/jcim-2015-0043
   Mehdizadeh R, 2013, IRAN J BASIC MED SCI, V16, P56
   Milajerdi A., 2017, Journal of Nutrition & Intermediary Metabolism, V9, P6, DOI 10.1016/j.jnim.2017.07.002
   Milajerdi A, 2018, COMPLEMENT THER MED, V41, P196, DOI 10.1016/j.ctim.2018.09.023
   Moallem SA, 2016, TOXICOL IND HEALTH, V32, P285, DOI 10.1177/0748233713500818
   Modabbernia A, 2012, PSYCHOPHARMACOLOGY, V223, P381, DOI 10.1007/s00213-012-2729-6
   Mohamadpour AH, 2013, IRAN J BASIC MED SCI, V16, P39
   Mohammadzadeh-Moghadam H, 2015, J EVID-BASED INTEGR, V20, P283, DOI 10.1177/2156587215583756
   Moradzadeh M, 2019, J CELL BIOCHEM, V120, P4732, DOI 10.1002/jcb.27525
   Moradzadeh M, 2018, ACTA POL PHARM, V75, P445
   Moratalla-López N, 2019, MOLECULES, V24, DOI 10.3390/molecules24152827
   Naeimifar A, 2020, J COSMET DERMATOL-US, V19, P2366, DOI 10.1111/jocd.13284
   Nikbakht-Jam I, 2016, EUR J INTEGR MED, V8, P307, DOI 10.1016/j.eujim.2015.12.008
   Noorbala AA, 2005, J ETHNOPHARMACOL, V97, P281, DOI 10.1016/j.jep.2004.11.004
   Pavlova MK, 2019, AM J MED, V132, P292, DOI 10.1016/j.amjmed.2018.09.021
   Penner IK, 2017, NAT REV NEUROL, V13, P662, DOI [10.1038/nrneurol.2017.117, 10.1038/nmeurol.2017.117]
   Piccardi M, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/429124
   Pitsikas N, 2016, MOLECULES, V21, DOI 10.3390/molecules21030303
   Plangar AF, 2019, J PHARMACOPUNCT, V22, P95, DOI 10.3831/KPI.2019.22.012
   Poma Anna, 2012, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, V11, P37
   Pourmasoumi M, 2019, PHARMACOL RES, V139, P348, DOI 10.1016/j.phrs.2018.11.038
   Rahmani J, 2019, PHYTOTHER RES, V33, P2244, DOI 10.1002/ptr.6420
   Ravindran Arun V, 2018, Focus (Am Psychiatr Publ), V16, P85, DOI 10.1176/appi.focus.16106
   Razavi BM, 2017, J SCI FOOD AGR, V97, P1679, DOI 10.1002/jsfa.8134
   Reboul E, 2013, NUTRIENTS, V5, P3563, DOI 10.3390/nu5093563
   Rezaee R., 2013, J COMPLEMENTARY INTE, V10, DOI 10.1515/jcim-2013-0011
   Riahi-Zanjani B, 2015, AVICENNA J PHYTOMEDI, V5, P441
   Riazi A, 2017, ITAL J MED, V11, P196, DOI 10.4081/itjm.2016.758
   Sadeghnia HR, 2008, J PHARM PHARM SCI, V11, P1
   Samarghandian S, 2010, PHARMACOGN MAG, V6, P309, DOI 10.4103/0973-1296.71799
   Schmidt M, 2007, WIEN MED WOCHENSCHR, V157, P315, DOI 10.1007/s10354-007-0428-4
   Sepahi S, 2018, AM J OPHTHALMOL, V190, P89, DOI 10.1016/j.ajo.2018.03.007
   Shamsa A, 2009, PHYTOMEDICINE, V16, P690, DOI 10.1016/j.phymed.2009.03.008
   Shariat Razavi Seyedeh Mahya, 2020, Asian Pac J Cancer Prev, V21, P1959, DOI 10.31557/APJCP.2020.21.7.1959
   Shaw JE, 2010, DIABETES RES CLIN PR, V87, P4, DOI 10.1016/j.diabres.2009.10.007
   Sheng L, 2006, EUR J PHARMACOL, V543, P116, DOI 10.1016/j.ejphar.2006.05.038
   Shimomura Iichiro, 2006, Masui, V55 Suppl, pS11
   Soeda S, 2001, LIFE SCI, V69, P2887, DOI 10.1016/S0024-3205(01)01357-1
   Sohaei S, 2020, INT J FOOD PROP, V23, P1386, DOI 10.1080/10942912.2020.1807567
   Sui XW, 2013, ARCH BIOCHEM BIOPHYS, V539, P203, DOI 10.1016/j.abb.2013.06.012
   Taavoni S, 2014, COMPLEMENT THER MED, V22, P601, DOI 10.1016/j.ctim.2014.05.004
   Takeda R., 2020, IMPROVEMENT QUALITY, V48, P497
   Tang FT, 2006, BIOCHEM PHARMACOL, V72, P558, DOI 10.1016/j.bcp.2006.05.018
   Trouba KJ, 2002, ANTIOXID REDOX SIGN, V4, P665, DOI 10.1089/15230860260220175
   TSENG TH, 1995, CANCER LETT, V97, P61, DOI 10.1016/0304-3835(95)03964-X
   van Dalfsen JH, 2019, J AFFECT DISORDERS, V256, P205, DOI 10.1016/j.jad.2019.05.047
   Whelan AM, 2009, J POPUL THER CLIN PH, V16, pE407
   Williams BA, 2005, AM J PHYSIOL-CELL PH, V288, pC650, DOI 10.1152/ajpcell.00475.2004
   Wong WL, 2014, LANCET GLOB HEALTH, V2, pE106, DOI 10.1016/S2214-109X(13)70145-1
   Xu Hui-Juan, 2012, Zhongguo Shi Yan Xue Ye Xue Za Zhi, V20, P57
   Xu YC, 2008, BRIT J PHARMACOL, V154, P1247, DOI 10.1038/bjp.2008.194
   Yang XG, 2017, J MOL NEUROSCI, V61, P581, DOI 10.1007/s12031-017-0899-8
   Yaribeygi H, 2019, J CELL PHYSIOL, V234, P2436, DOI 10.1002/jcp.27278
   Yosri H, 2017, INT IMMUNOPHARMACOL, V50, P305, DOI 10.1016/j.intimp.2017.07.012
   Zeinali M, 2019, IRAN J BASIC MED SCI, V22, P334, DOI 10.22038/ijbms.2019.34365.8158
   Zhang X, 2017, RESTOR NEUROL NEUROS, V35, P65, DOI 10.3233/RNN-160696
   Zhang ZY, 2013, PHARM BIOL, V51, P920, DOI 10.3109/13880209.2013.771190
   Zheng SG, 2005, BIOCHEM PHARMACOL, V70, P1192, DOI 10.1016/j.bcp.2005.07.034
   Zilaee M, 2019, RESP RES, V20, DOI 10.1186/s12931-019-0998-x
NR 154
TC 20
Z9 20
U1 0
U2 30
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD JAN
PY 2022
VL 36
IS 1
BP 98
EP 111
DI 10.1002/ptr.7286
EA SEP 2021
PG 14
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA YJ6VJ
UT WOS:000696498600001
PM 34532906
DA 2025-06-11
ER

PT J
AU Nishigaki, Y
   Fuku, N
   Tanaka, M
AF Nishigaki, Yutaka
   Fuku, Noriyuki
   Tanaka, Masashi
TI Mitochondrial haplogroups associated with lifestyle-related diseases and
   longevity in the Japanese population
SO GERIATRICS & GERONTOLOGY INTERNATIONAL
LA English
DT Review
DE haplogroup; lifestyle-related disease; longevity; mitochondrial genome;
   polymorphism
ID CYTOCHROME-B GENE; C-REACTIVE PROTEIN; SUPEROXIDE-PRODUCTION; METABOLIC
   SYNDROME; INSULIN-SECRETION; OXIDATIVE STRESS; DNA; RISK; POLYMORPHISMS;
   DYSFUNCTION
AB Recently published results on the association between metabolic syndrome, type 2 diabetes, myocardial infarction or atherothrombotic cerebral infarction and Japanese major haplogroups based on the comprehensive analysis of mitochondrial genome polymorphisms (mtSNP) in the coding region of human mitochondrial DNA (mtDNA), and longevity-related haplogroups are described in the present review. Our aim was to provide information that would allow us to predict the genetic risk for lifestyle-related diseases and thereby contribute to the primary prevention of these conditions. The mitochondrial genome variation is so large that a given haplogroup might consist of various subhaplogroups carrying unique and presumably functional mtSNP. The frequency of each subhaplogroup is sometimes only a few percent. Therefore, large-scale association study is necessary for elucidating the impact of each subhaplogroup on the susceptibility to various common diseases. Geriatr Gerontol Int 2010; 10 (Suppl. 1): S221-S235.
C1 [Nishigaki, Yutaka; Fuku, Noriyuki; Tanaka, Masashi] Tokyo Metropolitan Inst Gerontol, Dept Genom Longev & Hlth, Itabashi Ku, Tokyo 1730015, Japan.
C3 Tokyo Metropolitan Institute of Gerontology
RP Tanaka, M (corresponding author), Tokyo Metropolitan Inst Gerontol, Dept Genom Longev & Hlth, Itabashi Ku, 35-2 Sakae Cho, Tokyo 1730015, Japan.
EM mtanaka@tmig.or.jp
OI Fuku, Noriyuki/0000-0001-7792-5835
FU Japan Science and Technology Corporation; Ministry of Education,
   Culture, Sports, Science and Technology [C210832009, A [2]-15200051];
   Nervous and Mental Disorders of the Ministry of Health, Labour; Takeda
   Science Foundation; Scientific Research Sankyo Foundation of Life
   Science;  [18590317]; Grants-in-Aid for Scientific Research [21590411]
   Funding Source: KAKEN
FX This work was supported in part by the Support Project for Database
   Development from the Japan Science and Technology Corporation (to M.T.);
   a grant-in-aid (C210832009, A [2]-15200051 to M.T.) from the Ministry of
   Education, Culture, Sports, Science and Technology; by a grant from the
   Third-Term Comprehensive 10-year Strategy for Cancer Control (to M.T.);
   by grant 20B-13 from the program Research Grants for Nervous and Mental
   Disorders of the Ministry of Health, Labour, and Welfare (to M.T.); by a
   grant from the program Grants-in-Aid for (C) (18590317 to Y.N.); and by
   grants for scientific research from the Kao Research Council for the
   study of Healthcare Science (to Y.N.) and from the Takeda Science
   Foundation (to M.T. and to Y.N.) and Scientific Research Sankyo
   Foundation of Life Science (to Y.N.).
CR Abe S, 1998, EUR J HUM GENET, V6, P563, DOI 10.1038/sj.ejhg.5200239
   Abrams PA, 2004, NATURE, V431, P1048, DOI 10.1038/4311048a
   ALCOLADO JC, 1991, BRIT MED J, V302, P1178, DOI 10.1136/bmj.302.6786.1178
   Alexe G, 2006, DISCRETE APPL MATH, V154, P1039, DOI 10.1016/j.dam.2005.03.031
   Alexe G, 2004, DISCRETE APPL MATH, V145, P11, DOI 10.1016/j.dam.2003.09.004
   Alexe G, 2007, HUM GENET, V121, P347, DOI 10.1007/s00439-007-0330-6
   ANDERSON S, 1981, NATURE, V290, P457, DOI 10.1038/290457a0
   Andreu AL, 2000, PEDIATR RES, V48, P311, DOI 10.1203/00006450-200009000-00008
   Andreu AL, 1999, NEW ENGL J MED, V341, P1037, DOI 10.1056/NEJM199909303411404
   Baudouin SV, 2005, LANCET, V366, P2118, DOI 10.1016/S0140-6736(05)67890-7
   Bilal E, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002421
   BORECKI IB, 1993, AM J HUM GENET, V53, P676
   Brandon MC, 2005, NUCLEIC ACIDS RES, V33, pD611
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   COMUZZIE AG, 1995, GENET EPIDEMIOL, V12, P475, DOI 10.1002/gepi.1370120505
   de Grey ADNJ, 2006, FREE RADICAL RES, V40, P1244, DOI 10.1080/10715760600913176
   Dunbar SA, 2006, CLIN CHIM ACTA, V363, P71, DOI 10.1016/j.cccn.2005.06.023
   Elson JL, 2006, HUM GENET, V119, P241, DOI 10.1007/s00439-005-0123-8
   Fuku N, 2002, BIOCHEM BIOPH RES CO, V290, P1199, DOI 10.1006/bbrc.2002.6330
   Fuku N, 2007, AM J HUM GENET, V80, P407, DOI 10.1086/512202
   GRANTHAM R, 1974, SCIENCE, V185, P862, DOI 10.1126/science.185.4154.862
   Guo LJ, 2005, MITOCHONDRION, V5, P15, DOI 10.1016/j.mito.2004.09.001
   Guzik TJ, 2006, ARTERIOSCL THROM VAS, V26, P333, DOI 10.1161/01.ATV.0000196651.64776.51
   Hawkes K, 2004, NATURE, V428, P128, DOI 10.1038/428128a
   Hawkes K, 1998, P NATL ACAD SCI USA, V95, P1336, DOI 10.1073/pnas.95.3.1336
   Heitzer T, 2001, CIRCULATION, V104, P2673, DOI 10.1161/hc4601.099485
   HOLT IJ, 1990, AM J HUM GENET, V46, P428
   IKEBE S, 1995, MOL BRAIN RES, V28, P281, DOI 10.1016/0169-328X(94)00209-W
   Jolliffe IT., 2002, PRINCIPAL COMPONENT, P338, DOI [10.1007/0-387-22440-813, DOI 10.1038/NMETH.4346]
   Kanazawa M, 2005, WORLD REV NUTR DIET, V94, P1, DOI 10.1159/000088200
   Koh KK, 2002, CARDIOVASC RES, V55, P714, DOI 10.1016/S0008-6363(02)00487-X
   Kong QP, 2006, HUM MOL GENET, V15, P2076, DOI 10.1093/hmg/ddl130
   Kong QP, 2003, AM J HUM GENET, V73, P671, DOI 10.1086/377718
   Lenaz G, 2006, BBA-BIOENERGETICS, V1757, P1406, DOI 10.1016/j.bbabio.2006.05.007
   Lewis K, 1999, MECH AGEING DEV, V109, P43, DOI 10.1016/S0047-6374(99)00021-4
   Lowell BB, 2005, SCIENCE, V307, P384, DOI 10.1126/science.1104343
   Macaulay V, 2005, SCIENCE, V308, P1034, DOI 10.1126/science.1109792
   Maechler P, 2001, NATURE, V414, P807, DOI 10.1038/414807a
   Mishmar D, 2003, P NATL ACAD SCI USA, V100, P171, DOI 10.1073/pnas.0136972100
   Monti S, 2003, MACH LEARN, V52, P91, DOI 10.1023/A:1023949509487
   Montiel-Sosa F, 2006, GENE, V368, P21, DOI 10.1016/j.gene.2005.09.015
   Mootha VK, 2003, NAT GENET, V34, P267, DOI 10.1038/ng1180
   MYERS EW, 1988, COMPUT APPL BIOSCI, V4, P11, DOI 10.1093/bioinformatics/4.1.11
   Niemi AK, 2005, EUR J HUM GENET, V13, P166, DOI 10.1038/sj.ejhg.5201308
   Nishigaki Y, 2007, MITOCHONDRION, V7, P72, DOI 10.1016/j.mito.2006.11.002
   Nishigaki Y, 2007, HUM GENET, V120, P827, DOI 10.1007/s00439-006-0269-z
   Nishikawa T, 2000, NATURE, V404, P787, DOI 10.1038/35008121
   Okura T, 2003, HUM GENET, V113, P432, DOI 10.1007/s00439-003-0983-8
   Pakendorf B, 2005, ANNU REV GENOM HUM G, V6, P165, DOI 10.1146/annurev.genom.6.080604.162249
   Patti ME, 2003, P NATL ACAD SCI USA, V100, P8466, DOI 10.1073/pnas.1032913100
   Petersen KF, 2003, SCIENCE, V300, P1140, DOI 10.1126/science.1082889
   Petersen Kitt Falk, 2004, N Engl J Med, V350, P664
   Pyle A, 2005, ANN NEUROL, V57, P564, DOI 10.1002/ana.20417
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   ROUSSEEUW PJ, 1987, J COMPUT APPL MATH, V20, P53, DOI 10.1016/0377-0427(87)90125-7
   Ruiz-Pesini E, 2004, SCIENCE, V303, P223, DOI 10.1126/science.1088434
   Santoro A, 2006, BBA-BIOENERGETICS, V1757, P1388, DOI 10.1016/j.bbabio.2006.05.040
   Sattar N, 2003, CIRCULATION, V108, P414, DOI 10.1161/01.CIR.0000080897.52664.94
   Silva JP, 2000, NAT GENET, V26, P336, DOI 10.1038/81649
   Soejima A, 1996, J BIOL CHEM, V271, P26194, DOI 10.1074/jbc.271.42.26194
   Tanaka M, 1998, LANCET, V351, P185, DOI 10.1016/S0140-6736(05)78211-8
   Tanaka M, 2004, GENOME RES, V14, P1832, DOI 10.1101/gr.2286304
   Tanaka M, 2007, DIABETES, V56, P518, DOI 10.2337/db06-1105
   Tanaka Masashi, 2002, Journal of Neurology, V249, P11
   THOMAS F, 1994, DIABETES, V43, P63, DOI 10.2337/diabetes.43.1.63
   Wallace DC, 2005, ANNU REV GENET, V39, P359, DOI 10.1146/annurev.genet.39.110304.095751
   Yamada Y, 2006, THROMB HAEMOSTASIS, V96, P220, DOI 10.1160/TH06-02-0117
   Zalba G, 2001, HYPERTENSION, V38, P1395, DOI 10.1161/hy1201.099611
   Zhang J, 2003, P NATL ACAD SCI USA, V100, P1116, DOI 10.1073/pnas.242719399
NR 69
TC 23
Z9 26
U1 2
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1444-1586
EI 1447-0594
J9 GERIATR GERONTOL INT
JI Geriatr. Gerontol. Int.
PD JUL
PY 2010
VL 10
SU 1
BP S221
EP S235
DI 10.1111/j.1447-0594.2010.00599.x
PG 15
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 604WD
UT WOS:000278308300024
PM 20590837
DA 2025-06-11
ER

PT J
AU Tekin, HG
   Wu, JJ
   Burge, R
   Birt, J
   Egeberg, A
AF Tekin, Hasan G.
   Wu, Jashin J.
   Burge, Russel
   Birt, Julie
   Egeberg, Alexander
TI Burden and Disease Characteristics of Patients with Psoriatic Arthritis:
   A Population-based Cross-sectional Study
SO JOURNAL OF RHEUMATOLOGY
LA English
DT Article
DE PSORIATIC ARTHRITIS; PSORIASIS; DISEASE BURDEN; EPIDEMIOLOGY
ID METABOLIC SYNDROME; PREVALENCE; COMORBIDITIES; EPIDEMIOLOGY; REGISTER
AB Objective. To describe the prevalence and treatment regimes, disease characteristics, and comorbid diseases among patients with psoriatic arthritis (PsA) in Denmark.
   Methods. All Danish individuals aged >= 18 years with rheumatologist-diagnosed PsA were linked in nationwide administrative registers.
   Results. Among 4.7 million individuals in Denmark, 10,577 patients with PsA had been diagnosed by a rheumatologist. A female predominance (54.5-59.8%) was seen among patients with PsA, and about half of the patients (53.0%) had received no treatment or treatment only with nonsteroidal antiinflammatory drugs/systemic corticosteroids, while 32.9% had received nonbiological disease-modifying antirheumatic drugs (DMARD) and 14.1% had been treated with biologicals. Cutaneous psoriasis was recorded in 66.2-72.3% of patients with PsA, and patients with severe PsA had the highest prevalences of distal interphalangeal arthropathy, spondylitis, and arthritis mutilans. Smoking and comorbid diseases such as hypertension, diabetes, depression, and anxiety were seen frequently in patients with PsA, but did not significantly differ across severities of PsA.
   Conclusion. Disease burden appeared to be significant in patients with PsA across all severities. A considerable proportion of patients with PsA did not receive active antipsoriatic treatment, and about 1 out of 3 patients was not diagnosed with psoriasis. Cutaneous symptoms of psoriasis in patients with PsA might be either underreported or undertreated.
C1 [Tekin, Hasan G.; Egeberg, Alexander] Univ Copenhagen, Herlev & Gentofte Hosp, Dept Dermatol & Allergy, Hellerup, Denmark.
   [Wu, Jashin J.] Kaiser Permanente, Los Angeles Med Ctr, Dept Dermatol, Los Angeles, CA USA.
   [Burge, Russel; Birt, Julie] Eli Lilly & Co, Indianapolis, IN 46285 USA.
   [Burge, Russel] Univ Cincinnati, Div Pharmaceut Sci, Cincinnati, OH USA.
C3 University of Copenhagen; Kaiser Permanente; University of California
   System; University of California Los Angeles; University of California
   Los Angeles Medical Center; Eli Lilly; University System of Ohio;
   University of Cincinnati
RP Egeberg, A (corresponding author), Herlev & Gentofte Hosp, Dept Dermatol & Allergy, Kildegardsvej 28, DK-2900 Hellerup, Denmark.
EM alexander.egeberg@gmail.com
RI Egeberg, Alexander/AFO-3479-2022; Burge, Russel/AAI-2390-2021
OI Burge, Russel/0000-0001-7907-6400; Tekin, Hasan
   Gokcer/0000-0001-7187-7940; Egeberg, Alexander/0000-0001-8257-1816; Wu,
   Jashin/0000-0002-1722-1892
FU Eli Lilly and Co.; Pfizer; Eli Lilly; Danish National Psoriasis
   Foundation; Kgl Hofbundtmager Aage Bang Foundation
FX This study was funded by Eli Lilly and Co. The funding source
   participated in interpretation of the final analyzed study results, but
   had no access to the raw data, and did not participate in data
   collection, management, or analysis. Dr. Wu is an investigator for
   AbbVie, Amgen, Eli Lilly, Janssen, Novartis, and Regeneron. Dr. Burge
   and J. Birt are currently employed by Eli Lilly and Co. Dr. Egeberg has
   received research funding from Pfizer, Eli Lilly, the Danish National
   Psoriasis Foundation, and the Kgl Hofbundtmager Aage Bang Foundation,
   and honoraria as a consultant and/or speaker from Leo Pharma, Samsung
   Bioepis Co. Ltd., Pfizer, Eli Lilly, Novartis, Galderma, and Janssen
   Pharmaceuticals.
CR Ahlehoff O, 2012, EUR HEART J, V33, P2054, DOI 10.1093/eurheartj/ehr285
   Andersen TF, 1999, DAN MED BULL, V46, P263
   Baadsgaard M, 2011, SCAND J PUBLIC HEALT, V39, P103, DOI 10.1177/1403494811405098
   Bostoen J, 2014, J EUR ACAD DERMATOL, V28, P507, DOI 10.1111/jdv.12071
   Caso F, 2018, CLIN RHEUMATOL, V37, P579, DOI 10.1007/s10067-017-3975-0
   Christophers E, 2001, CLIN EXP DERMATOL, V26, P314, DOI 10.1046/j.1365-2230.2001.00832.x
   Ciccia F, 2017, NEW ENGL J MED, V376, P2094, DOI 10.1056/NEJMc1704342
   Danmarks Statistik, HLTH CAR VIS PHYS
   Eder L, 2012, ANN RHEUM DIS, V71, P219, DOI 10.1136/ard.2010.147793
   Egeberg A, 2018, J EUR ACAD DERMATOL, V32, pE4, DOI 10.1111/jdv.14427
   Egeberg A, 2017, ANN RHEUM DIS, V76, P1591, DOI 10.1136/annrheumdis-2016-210963
   Egeberg A, 2016, J INVEST DERMATOL, V136, P93, DOI 10.1038/JID.2015.350
   Husted JA, 2013, J RHEUMATOL, V40, P1349, DOI 10.3899/jrheum.121500
   Jamnitski A, 2013, ANN RHEUM DIS, V72, P211, DOI 10.1136/annrheumdis-2011-201194
   Kildemoes HW, 2011, SCAND J PUBLIC HEALT, V39, P38, DOI 10.1177/1403494810394717
   Mease PJ, 2013, J AM ACAD DERMATOL, V69, P729, DOI 10.1016/j.jaad.2013.07.023
   MOLL J M H, 1973, Seminars in Arthritis and Rheumatism, V3, P55, DOI 10.1016/0049-0172(73)90035-8
   Ogdie A, 2015, RHEUM DIS CLIN N AM, V41, P545, DOI 10.1016/j.rdc.2015.07.001
   Ogdie A, 2015, CURR OPIN RHEUMATOL, V27, P118, DOI 10.1097/BOR.0000000000000152
   Ogdie A, 2013, RHEUMATOLOGY, V52, P568, DOI 10.1093/rheumatology/kes324
   Schmidt M, 2014, EUR J EPIDEMIOL, V29, P541, DOI 10.1007/s10654-014-9930-3
   Zisman D, 2012, RHEUMATOL INT, V32, P595, DOI 10.1007/s00296-010-1673-1
NR 22
TC 11
Z9 11
U1 0
U2 0
PU J RHEUMATOL PUBL CO
PI TORONTO
PA 365 BLOOR ST E, STE 901, TORONTO, ONTARIO M4W 3L4, CANADA
SN 0315-162X
EI 1499-2752
J9 J RHEUMATOL
JI J. Rheumatol.
PD JUL 1
PY 2019
VL 46
IS 7
BP 716
EP 720
DI 10.3899/jrheum.180670
PG 5
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA IJ3YJ
UT WOS:000475840400011
PM 30824662
OA Bronze
DA 2025-06-11
ER

PT J
AU Seino, S
   Tanaka, Y
   Honma, T
   Yanaka, M
   Sato, K
   Shinohara, N
   Ito, J
   Tsuduki, T
   Nakagawa, K
   Miyazawa, T
   Ikeda, I
AF Seino, Satoshi
   Tanaka, Yurie
   Honma, Taro
   Yanaka, Miyuki
   Sato, Kenta
   Shinohara, Nahoko
   Ito, Junya
   Tsuduki, Tsuyoshi
   Nakagawa, Kiyotaka
   Miyazawa, Teruo
   Ikeda, Ikuo
TI Atopic dermatitis causes lipid accumulation in the liver of NC/Nga mouse
SO JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
LA English
DT Article
DE allergy; DNA microarray; lipid metabolism; liver; NC/Nga
ID CONJUGATED TRIENE SYSTEM; ALPHA-ELEOSTEARIC-ACID; METABOLIC SYNDROME;
   OXIDATIVE STRESS; FOOD-INTAKE; TNF-ALPHA; OBESITY; P53; DISEASE;
   APOPTOSIS
AB Various factors have been reported to influence lipid metabolism and cause metabolic syndrome. However, the influence of allergy on the liver that plays important role of lipid metabolism has not been clarified. The aim of this study was to examine the influence of allergy on lipid metabolism of liver. A model of atopic dermatitis was developed in the NC/Nga mouse using picryl chloride to induce allergy. Lipid metabolism parameters were measured and the mechanism of changes in these parameters was examined using DNA microarray analysis and quantitative reverse transcriptase PCR. Triacylglycerol accumulation was promoted in the liver in the mouse atopic dermatitis model despite reductions in food intake, body weight gain, and serum glucose. As this mechanism, it was thought that atopic dermatitis caused the suppression of fatty acid beta-oxidation. These results suggest that atopic dermatitis causes lipid accumulation in the liver.
C1 [Seino, Satoshi; Tanaka, Yurie; Honma, Taro; Yanaka, Miyuki; Sato, Kenta; Shinohara, Nahoko; Ito, Junya; Tsuduki, Tsuyoshi; Ikeda, Ikuo] Tohoku Univ, Grad Sch Agr, Lab Food & Biomol Sci, Sendai, Miyagi 9818555, Japan.
   [Nakagawa, Kiyotaka; Miyazawa, Teruo] Tohoku Univ, Grad Sch Agr, Food & Biodynam Chem Lab, Sendai, Miyagi 9818555, Japan.
C3 Tohoku University; Tohoku University
RP Tsuduki, T (corresponding author), Tohoku Univ, Grad Sch Agr, Lab Food & Biomol Sci, Sendai, Miyagi 9818555, Japan.
EM tsuzukit@biochem.tohoku.ac.jp
RI Ito, Junya/KPA-7635-2024; Tsuduki, Tsuyoshi/T-2697-2019
OI Tsuduki, Tsuyoshi/0000-0001-7810-0528; Ito, Junya/0000-0001-9190-4969
FU Uehara Memorial Foundation, Japan; Grants-in-Aid for Scientific Research
   [20228002] Funding Source: KAKEN
FX This study was supported from The Uehara Memorial Foundation, Japan.
CR Adam TC, 2007, PHYSIOL BEHAV, V91, P449, DOI 10.1016/j.physbeh.2007.04.011
   Ashcroft M, 1999, MOL CELL BIOL, V19, P1751
   Bray GA, 1998, AM J CLIN NUTR, V68, P1157, DOI 10.1093/ajcn/68.6.1157
   Bunz F, 1998, SCIENCE, V282, P1497, DOI 10.1126/science.282.5393.1497
   Chida Y, 2008, PSYCHOSOM MED, V70, P102, DOI 10.1097/PSY.0b013e31815c1b71
   Chopin V, 2004, EXP CELL RES, V298, P560, DOI 10.1016/j.yexcr.2004.04.038
   Dhabhar FS, 2009, NEUROIMMUNOMODULAT, V16, P300, DOI 10.1159/000216188
   FANELLI C, 1993, J CLIN INVEST, V92, P1617, DOI 10.1172/JCI116746
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gregersen N, 2001, HUM MUTAT, V18, P169, DOI 10.1002/humu.1174
   Hartgerink-Lutgens I, 2009, CLIN EXP ALLERGY, V39, P500, DOI 10.1111/j.1365-2222.2009.03200.x
   Hashimoto T, 2000, J BIOL CHEM, V275, P28918, DOI 10.1074/jbc.M910350199
   Inoue N, 2008, J BIOL CHEM, V283, P21220, DOI 10.1074/jbc.M801824200
   Johnson D, 2007, DIABETES, V56, P1694, DOI 10.2337/db07-0026
   Kamigaki M, 2006, BIOCHEM BIOPH RES CO, V339, P624, DOI 10.1016/j.bbrc.2005.11.059
   Kersten S, 1999, J CLIN INVEST, V103, P1489, DOI 10.1172/JCI6223
   Kim WH, 2005, CELL SIGNAL, V17, P1516, DOI 10.1016/j.cellsig.2005.03.020
   Kuo LE, 2007, NAT MED, V13, P803, DOI 10.1038/nm1611
   KURAISHI Y, 1995, EUR J PHARMACOL, V275, P229, DOI 10.1016/0014-2999(94)00780-B
   Lee HS, 2006, BRIT J DERMATOL, V155, P33, DOI 10.1111/j.1365-2133.2006.07303.x
   Leu JIJ, 2007, GENE DEV, V21, P3095, DOI 10.1101/gad.1567107
   Leung DYM, 2003, LANCET, V361, P151, DOI 10.1016/S0140-6736(03)12193-9
   MARTI O, 1994, PHYSIOL BEHAV, V55, P747, DOI 10.1016/0031-9384(94)90055-8
   Matsuoka H, 2003, ALLERGY, V58, P139, DOI 10.1034/j.1398-9995.2003.23790.x
   Moreau D, 2009, AM J CLIN NUTR, V89, P1292, DOI 10.3945/ajcn.2008.26954
   NAKAMURA T, 1994, ATHEROSCLEROSIS, V107, P239, DOI 10.1016/0021-9150(94)90025-6
   Ohmura T, 2004, INT ARCH ALLERGY IMM, V133, P389, DOI 10.1159/000077359
   ROTHMAN DL, 1991, SCIENCE, V254, P573, DOI 10.1126/science.1948033
   ROUSER G, 1970, LIPIDS, V5, P494, DOI 10.1007/BF02531316
   RUSSELL DW, 1992, BIOCHEMISTRY-US, V31, P4737, DOI 10.1021/bi00135a001
   Schmitt J, 2009, BRIT J DERMATOL, V161, P878, DOI 10.1111/j.1365-2133.2009.09309.x
   Schwartz AR, 2003, PSYCHOSOM MED, V65, P22, DOI 10.1097/01.PSY.0000046075.79922.61
   Sears MR, 1997, LANCET, V350, P1
   Shalev AY, 1996, PSYCHOSOM MED, V58, P165, DOI 10.1097/00006842-199603000-00012
   Sharabi Y, 2000, AM J MED, V109, P171, DOI 10.1016/S0002-9343(00)00434-4
   SIBBALD B, 1991, THORAX, V46, P895, DOI 10.1136/thx.46.12.895
   Sivertsen B, 2009, J PSYCHOSOM RES, V67, P109, DOI 10.1016/j.jpsychores.2009.05.001
   Tsuduki T, 2009, J AGR FOOD CHEM, V57, P11024, DOI 10.1021/jf903132r
   Tsuzuki T, 2005, LIPIDS, V40, P1117, DOI 10.1007/s11745-005-1475-0
   Tsuzuki T, 2004, CARCINOGENESIS, V25, P1417, DOI 10.1093/carcin/bgh109
   Tsuzuki T, 2008, CARCINOGENESIS, V29, P797, DOI 10.1093/carcin/bgm298
   Tsuzuki T, 2007, BBA-MOL CELL BIOL L, V1771, P20, DOI 10.1016/j.bbalip.2006.11.006
   Tsuzuki T, 2006, J NUTR BIOCHEM, V17, P518, DOI 10.1016/j.jnutbio.2005.09.006
   Vallès A, 2000, AM J PHYSIOL-REG I, V279, pR1138, DOI 10.1152/ajpregu.2000.279.3.R1138
   Vestergaard C, 1999, J CLIN INVEST, V104, P1097, DOI 10.1172/JCI7613
   Wheatcroft SB, 2009, TRENDS ENDOCRIN MET, V20, P153, DOI 10.1016/j.tem.2009.01.002
   Yabe D, 2003, P NATL ACAD SCI USA, V100, P3155, DOI 10.1073/pnas.0130116100
   Yahagi N, 2004, J BIOL CHEM, V279, P20571, DOI 10.1074/jbc.M400884200
   Yuan XY, 2011, EUR J PHARMACOL, V658, P263, DOI 10.1016/j.ejphar.2011.02.013
NR 49
TC 24
Z9 26
U1 1
U2 14
PU JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
PI KYOTO
PA KYOTO PREFECTURAL UNIV MED, GRAD SCH MEDICAL SCIENCE, DEPT MOLECULAR
   GASTROENTEROLOGY & HEPATOLOGY, KYOTO, 602-8566, JAPAN
SN 0912-0009
EI 1880-5086
J9 J CLIN BIOCHEM NUTR
JI J. Clin. Biochem. Nutr.
PD MAR 1
PY 2012
VL 50
IS 2
BP 152
EP 157
DI 10.3164/jcbn.11-29
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 922DB
UT WOS:000302525900009
PM 22448097
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Seligowski, AV
   Webber, TK
   Marvar, PJ
   Ressler, KJ
   Philip, NS
AF Seligowski, Antonia, V
   Webber, Theresa K.
   Marvar, Paul J.
   Ressler, Kerry J.
   Philip, Noah S.
TI Involvement of the brain-heart axis in the link between PTSD and
   cardiovascular disease
SO DEPRESSION AND ANXIETY
LA English
DT Review
DE autonomic; brain-heart axis; cardiovascular disease; inflammation; PTSD;
   sex
ID POSTTRAUMATIC-STRESS-DISORDER; TRANSCRANIAL MAGNETIC STIMULATION;
   ANGIOTENSIN-ALDOSTERONE-SYSTEM; RATE-VARIABILITY; BLOOD-PRESSURE; MAJOR
   DEPRESSION; SEX-DIFFERENCES; ENDOTHELIAL FUNCTION; PROLONGED EXPOSURE;
   METABOLIC SYNDROME
AB Posttraumatic stress disorder (PTSD) has long been associated with a heightened risk of cardiovascular disease (CVD). A number of mechanisms have been implicated to underlie this brain-heart axis relationship, such as altered functioning of the autonomic nervous system and increased systemic inflammation. While neural alterations have repeatedly been observed in PTSD, they are rarely considered in the PTSD-CVD link. The brain-heart axis is a pathway connecting frontal and limbic brain regions to the brainstem and periphery via the autonomic nervous system and it may be a promising model for understanding CVD risk in PTSD given its overlap with PTSD neural deficits. We first provide a summary of the primary mechanisms implicated in the association between PTSD and CVD. We then review the brain-heart axis and its relevance to PTSD, as well as findings from PTSD trials demonstrating that a number of PTSD treatments have effects on areas of the brain-heart axis. Finally, we discuss sex considerations in the PTSD-CVD link. A critical next step in this study is to determine if PTSD treatments that affect the brain-heart axis (e.g., brain stimulation that improves autonomic function) also reduce the risk of CVD.
C1 [Seligowski, Antonia, V; Ressler, Kerry J.] Harvard Med Sch, Dept Psychiat, Boston, MA USA.
   [Seligowski, Antonia, V; Webber, Theresa K.; Ressler, Kerry J.] McLean Hosp, Div Depress & Anxiety Disorders, Belmont, MA 02178 USA.
   [Marvar, Paul J.] George Washington Univ, Dept Pharmacol & Physiol, Washington, DC USA.
   [Philip, Noah S.] Providence VA Med Ctr, VA RR&D Ctr Neurorestorat & Neurotechnol, Providence, RI USA.
   [Philip, Noah S.] Brown Univ, Dept Psychiat & Human Behav, Alpert Med Sch, Providence, RI 02912 USA.
C3 Harvard University; Harvard Medical School; Harvard University; Harvard
   University Medical Affiliates; McLean Hospital; George Washington
   University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Providence VA Medical Center; Brown University
RP Seligowski, AV (corresponding author), 115 Mill St,Mail Stop 212, Belmont, MA 02478 USA.
EM aseligowski@mclean.harvard.edu
RI Philip, Ninan/AAQ-4553-2020; Seligowski, Antonia/GLV-3861-2022; Ressler,
   Kerry/N-8741-2018; Philip, Noah/C-3714-2016
OI Philip, Noah/0000-0002-4889-8775
FU American Heart Association; National Institutes of Health; National
   Institute of Mental Health [P50MH115874] Funding Source: NIH RePORTER
FX American Heart Association; National Institutes of Health
CR Akiki Teddy J, 2017, Chronic Stress (Thousand Oaks), V1, DOI 10.1177/2470547017724069
   American Psychological Association, 2020, ABOUT AS
   Baker DG, 1999, AM J PSYCHIAT, V156, P585
   Barredo J, 2019, DEPRESS ANXIETY, V36, P1047, DOI 10.1002/da.22952
   Bartoli F, 2013, METAB SYNDR RELAT D, V11, P301, DOI 10.1089/met.2013.0010
   BERKMAN LF, 1992, ANN INTERN MED, V117, P1003, DOI 10.7326/0003-4819-117-12-1003
   Boggio PS, 2010, J CLIN PSYCHIAT, V71, P992, DOI 10.4088/JCP.08m04638blu
   Bourassa KJ, 2020, PSYCHOSOM MED, V82, P108, DOI 10.1097/PSY.0000000000000758
   Breit S, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00044
   Bremner J Douglas, 2021, J Affect Disord Rep, V6, DOI 10.1016/j.jadr.2021.100190
   Bremner JD, 2020, J PERS MED, V10, DOI 10.3390/jpm10030119
   Brudey C, 2015, AM J PHYSIOL-REG I, V309, pR315, DOI 10.1152/ajpregu.00343.2014
   Brunet A, 2008, J PSYCHIATR RES, V42, P503, DOI 10.1016/j.jpsychires.2007.05.006
   Buckley TC, 2001, PSYCHOSOM MED, V63, P585, DOI 10.1097/00006842-200107000-00011
   Burbiel JC, 2015, MILITARY MED RES, V2, DOI 10.1186/s40779-015-0053-2
   Burg MM, 2016, CURR CARDIOL REP, V18, DOI 10.1007/s11886-016-0770-5
   Carpenter LL, 2018, J AFFECT DISORDERS, V235, P414, DOI 10.1016/j.jad.2018.04.009
   Chang HA, 2013, PSYCHIAT INVEST, V10, P121, DOI 10.4306/pi.2013.10.2.121
   Charkoudian N, 2017, CLIN AUTON RES, V27, P149, DOI 10.1007/s10286-017-0420-z
   Chittaranjan A, 2013, INT CLIN PSYCHOPHARM, V28, P145, DOI 10.1097/YIC.0b013e32835d735d
   Cohen H, 2004, AM J PSYCHIAT, V161, P515, DOI 10.1176/appi.ajp.161.3.515
   Cosmo C, 2022, NEUROMODULATION, V25, P588, DOI 10.1111/ner.13529
   Crombie KM, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-020-80776-2
   Daskalakis NP, 2013, ENDOCRIN METAB CLIN, V42, P503, DOI 10.1016/j.ecl.2013.05.004
   DAVIDSON JRT, 1991, PSYCHOL MED, V21, P713, DOI 10.1017/S0033291700022352
   de Oliveira JF, 2018, PSYCHIAT RES, V260, P111, DOI 10.1016/j.psychres.2017.11.061
   Dedert EA, 2010, ANN BEHAV MED, V39, P61, DOI 10.1007/s12160-010-9165-9
   Dunne RL, 2012, CLIN J PAIN, V28, P755, DOI 10.1097/AJP.0b013e318243e16b
   Edmondson D, 2017, LANCET PSYCHIAT, V4, P320, DOI 10.1016/S2215-0366(16)30377-7
   Edmondson D, 2013, AM HEART J, V166, P806, DOI 10.1016/j.ahj.2013.07.031
   Edmondson D, 2013, PROG CARDIOVASC DIS, V55, P548, DOI 10.1016/j.pcad.2013.03.004
   Edmondson D, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038915
   Edmondson D, 2011, J PSYCHIATR RES, V45, P1621, DOI 10.1016/j.jpsychires.2011.07.004
   Ehlers A, 2010, INT J PSYCHOPHYSIOL, V78, P27, DOI 10.1016/j.ijpsycho.2010.04.009
   Engel CC, 2014, MED CARE, V52, pS57, DOI 10.1097/MLR.0000000000000237
   Fecteau G., 1999, Behavioural and Cognitive Psychotherapy, V27, P201, DOI [DOI 10.1017/S135246589927302X, 10.1017/S135246589927302X]
   Fenster RJ, 2018, NAT REV NEUROSCI, V19, P535, DOI 10.1038/s41583-018-0039-7
   Fonkoue IT, 2020, CLIN AUTON RES, V30, P409, DOI 10.1007/s10286-020-00729-7
   Friend SF, 2022, EUR J NEUROSCI, V55, P2297, DOI 10.1111/ejn.15031
   Gilsanz P, 2017, PSYCHOL MED, V47, P1370, DOI 10.1017/S0033291716003378
   Glassman AH, 2002, JAMA-J AM MED ASSOC, V288, P701, DOI 10.1001/jama.288.6.701
   Glover EM, 2013, J PSYCHIATR NEUROSCI, V38, P341, DOI 10.1503/jpn.120129
   Glover EM, 2012, BIOL PSYCHIAT, V72, P19, DOI 10.1016/j.biopsych.2012.02.031
   Grant S, 2018, J TRAUMA DISSOCIATIO, V19, P39, DOI 10.1080/15299732.2017.1289493
   Grassi G, 2003, J HYPERTENS, V21, P1761, DOI 10.1097/00004872-200309000-00027
   Griffin MG, 2012, J TRAUMA STRESS, V25, P25, DOI 10.1002/jts.21667
   Gurel NZ, 2020, NEUROBIOL STRESS, V13, DOI 10.1016/j.ynstr.2020.100264
   Hao PP, 2015, NAT REV CARDIOL, V12, P115, DOI 10.1038/nrcardio.2014.177
   HASHIMOTO M, 1995, CIRCULATION, V92, P3431, DOI 10.1161/01.CIR.92.12.3431
   Hashimoto M, 2002, MENOPAUSE, V9, P58, DOI 10.1097/00042192-200201000-00009
   Hauschildt M, 2011, BIOL PSYCHOL, V88, P215, DOI 10.1016/j.biopsycho.2011.08.004
   Hayes JP, 2012, BIOL MOOD ANXIETY DI, V2, DOI 10.1186/2045-5380-2-9
   Heath NM, 2013, CYTOKINE, V63, P172, DOI 10.1016/j.cyto.2013.04.030
   Heim C, 2001, AM J PSYCHIAT, V158, P575, DOI 10.1176/appi.ajp.158.4.575
   Heppner PS, 2009, BMC MED, V7, DOI 10.1186/1741-7015-7-1
   Hoerster KD, 2019, PREV MED REP, V15, DOI 10.1016/j.pmedr.2019.100930
   Hollifield M, 2007, J NERV MENT DIS, V195, P504, DOI 10.1097/NMD.0b013e31803044f8
   Inslicht SS, 2013, J PSYCHIATR RES, V47, P64, DOI 10.1016/j.jpsychires.2012.08.027
   Iseger TA, 2020, BRAIN STIMUL, V13, P167, DOI 10.1016/j.brs.2019.09.016
   Jenkins J, 2002, BMC PSYCHIATRY, V2, DOI 10.1186/1471-244X-2-1
   Jovanovic T, 2012, NEUROPHARMACOLOGY, V62, P695, DOI 10.1016/j.neuropharm.2011.02.023
   Jovanovic T, 2009, INT J PSYCHOPHYSIOL, V71, P264, DOI 10.1016/j.ijpsycho.2008.10.007
   KANNEL WB, 1976, ANN INTERN MED, V85, P447, DOI 10.7326/0003-4819-85-4-447
   Keane TM, 1998, J CONSULT CLIN PSYCH, V66, P914, DOI 10.1037/0022-006X.66.6.914
   Keary TA, 2009, INT J PSYCHOPHYSIOL, V73, P257, DOI 10.1016/j.ijpsycho.2009.04.003
   Khoury NM, 2012, J CLIN PSYCHIAT, V73, P849, DOI 10.4088/JCP.11m07316
   Kibler JL, 2014, WORLD J CARDIOL, V6, P455, DOI 10.4330/wjc.v6.i6.455
   Kilpatrick DG, 2013, J TRAUMA STRESS, V26, P537, DOI 10.1002/jts.21848
   Kim TD, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9020107
   Kingma JG, 2018, Autonomic Nervous System
   Klein IHHT, 2003, J AM SOC NEPHROL, V14, P425, DOI 10.1097/01.ASN.0000045049.72965.B7
   Koek RJ, 2019, PROG NEURO-PSYCHOPH, V92, P148, DOI 10.1016/j.pnpbp.2019.01.004
   Koenen KC, 2017, PSYCHOL MED, V47, P209, DOI [10.1017/s0033291716002294, 10.1017/S0033291716002294]
   Krediet E, 2020, INT J NEUROPSYCHOPH, V23, P385, DOI 10.1093/ijnp/pyaa018
   Lamb DG, 2017, FRONT MED-LAUSANNE, V4, DOI 10.3389/fmed.2017.00124
   Lindauer RTL, 2006, PSYCHOSOM MED, V68, P33, DOI 10.1097/01.psy.0000188566.35902.e7
   Lindqvist D, 2014, BRAIN BEHAV IMMUN, V42, P81, DOI 10.1016/j.bbi.2014.06.003
   Lipov E, 2015, CURR PSYCHIAT REP, V17, DOI 10.1007/s11920-015-0599-4
   Lopez WD, 2011, JOGNN-J OBST GYN NEO, V40, P422, DOI 10.1111/j.1552-6909.2011.01261.x
   Loucks L, 2019, J ANXIETY DISORD, V61, P55, DOI 10.1016/j.janxdis.2018.06.004
   Makovac E, 2017, NEUROSCI BIOBEHAV R, V74, P330, DOI 10.1016/j.neubiorev.2016.05.001
   Manthey A, 2021, EUR J PSYCHOTRAUMATO, V12, DOI 10.1080/20008198.2021.1929025
   Maples-Keller JL, 2019, J ANXIETY DISORD, V68, DOI 10.1016/j.janxdis.2019.102147
   Marvar PJ, 2014, BIOL PSYCHIAT, V75, P864, DOI 10.1016/j.biopsych.2013.08.024
   McCleery JM, 2004, J TRAUMA STRESS, V17, P485, DOI 10.1007/s10960-004-5797-5
   Medina D, 2020, CLIN AUTON RES, V30, P393, DOI 10.1007/s10286-020-00720-2
   Mehta ND, 2020, SOC COGN AFFECT NEUR, V15, P1046, DOI 10.1093/scan/nsz100
   Mendelsohn ME, 1999, NEW ENGL J MED, V340, P1801, DOI 10.1056/NEJM199906103402306
   Michopoulos V, 2017, NEUROPSYCHOPHARMACOL, V42, P254, DOI 10.1038/npp.2016.146
   Michopoulos V, 2016, EXP NEUROL, V284, P220, DOI 10.1016/j.expneurol.2016.05.038
   Michopoulos V, 2015, AM J PSYCHIAT, V172, P353, DOI 10.1176/appi.ajp.2014.14020263
   Mills KL, 2006, AM J PSYCHIAT, V163, P652, DOI 10.1176/appi.ajp.163.4.652
   Minassian A, 2015, JAMA PSYCHIAT, V72, P979, DOI 10.1001/jamapsychiatry.2015.0922
   Minassian A, 2014, PSYCHOSOM MED, V76, P292, DOI 10.1097/PSY.0000000000000056
   Morris MC, 2016, CLIN PSYCHOL REV, V49, P79, DOI 10.1016/j.cpr.2016.09.001
   Morris MC, 2012, CLIN PSYCHOL REV, V32, P301, DOI 10.1016/j.cpr.2012.02.002
   Myers B, 2017, PHYSIOL BEHAV, V172, P49, DOI 10.1016/j.physbeh.2016.10.015
   Noble LJ, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/tp.2017.191
   Nylocks KM, 2015, AM J MED GENET B, V168, P307, DOI 10.1002/ajmg.b.32313
   O'Donnell CJ, 2021, JAMA CARDIOL, V6, P1207, DOI 10.1001/jamacardio.2021.2530
   O'Donovan A, 2012, BRAIN BEHAV IMMUN, V26, P642, DOI 10.1016/j.bbi.2012.02.003
   ORR SP, 1993, J ABNORM PSYCHOL, V102, P152, DOI 10.1037/0021-843X.102.1.152
   Pan XF, 2018, FRONT MOL NEUROSCI, V11, DOI 10.3389/fnmol.2018.00450
   Park JE, 2017, PSYCHIAT RES, V255, P72, DOI 10.1016/j.psychres.2017.05.011
   Parrish JN, 2019, TRANSL PSYCHIAT, V9, DOI 10.1038/s41398-019-0374-0
   Petrosino NJ, 2020, NEUROPSYCHOPHARMACOL, V45, P940, DOI 10.1038/s41386-019-0584-4
   Philip NS, 2019, AM J PSYCHIAT, V176, P939, DOI 10.1176/appi.ajp.2019.18101160
   Philip NS, 2018, BIOL PSYCHIAT, V83, P263, DOI 10.1016/j.biopsych.2017.07.021
   Pineles SL, 2016, J ABNORM PSYCHOL, V125, P349, DOI 10.1037/abn0000138
   Pizzi C, 2009, CLIN PHARMACOL THER, V86, P527, DOI 10.1038/clpt.2009.121
   Platt JM, 2016, J TRAUMA STRESS, V29, P205, DOI 10.1002/jts.22092
   Poppa T, 2020, INT J PSYCHOPHYSIOL, V149, P25, DOI 10.1016/j.ijpsycho.2019.12.011
   Pulcu E, 2019, BIOL PSYCHIAT, V86, P397, DOI 10.1016/j.biopsych.2019.04.010
   Rabe S, 2006, APPL PSYCHOPHYS BIOF, V31, P315, DOI 10.1007/s10484-006-9027-1
   Olmsted KRL, 2020, JAMA PSYCHIAT, V77, P130, DOI 10.1001/jamapsychiatry.2019.3474
   Raskind MA, 2018, NEW ENGL J MED, V378, P507, DOI 10.1056/NEJMoa1507598
   Reist C, 2021, CNS SPECTRUMS, V26, P338, DOI 10.1017/S1092852920001121
   Remue J, 2016, NEUROPSYCHOLOGY, V30, P756, DOI 10.1037/neu0000255
   Ross DA, 2017, JAMA PSYCHIAT, V74, P407, DOI 10.1001/jamapsychiatry.2016.3325
   Sagud M, 2017, PSYCHIAT DANUB, V29, P421, DOI 10.24869/psyd.2017.421
   Sahar T, 2001, BIOL PSYCHIAT, V49, P637, DOI 10.1016/S0006-3223(00)01045-3
   Seligowski AV, 2021, NEUROPSYCHOPHARMACOL, V46, P750, DOI 10.1038/s41386-020-00923-1
   Seligowski AV, 2021, BEHAV BRAIN RES, V396, DOI 10.1016/j.bbr.2020.112914
   Seligowski AV, 2020, BIOL PSYCHIAT-COGN N, V5, P381, DOI 10.1016/j.bpsc.2019.12.006
   Sheynin J, 2020, DEPRESS ANXIETY, V37, P1037, DOI 10.1002/da.23075
   Siegel AN, 2021, J PSYCHIATR RES, V139, P71, DOI 10.1016/j.jpsychires.2021.05.019
   Spitzer C, 2010, J PSYCHIATR RES, V44, P15, DOI 10.1016/j.jpsychires.2009.06.002
   Steckler T, 2012, NEUROPHARMACOLOGY, V62, P617, DOI 10.1016/j.neuropharm.2011.06.012
   Stein MB, 2021, BIOL PSYCHIAT, V90, P473, DOI 10.1016/j.biopsych.2021.05.012
   Stevens JS, 2018, NEUROIMAGE-CLIN, V17, P650, DOI 10.1016/j.nicl.2017.11.016
   Stout DM, 2019, BIOL PSYCHIAT, V86, P874, DOI 10.1016/j.biopsych.2019.09.026
   Sueta D, 2014, AM J HYPERTENS, V27, P1464, DOI 10.1093/ajh/hpu076
   Sumner JA, 2020, PSYCHOL MED, V50, P38, DOI 10.1017/S0033291718003914
   Taylor LE, 2016, AM J PHYSIOL-REG I, V311, pR714, DOI 10.1152/ajpregu.00202.2016
   Terock J, 2019, PSYCHONEUROENDOCRINO, V107, P232, DOI 10.1016/j.psyneuen.2019.05.026
   Terock J, 2019, PSYCHOL MED, V49, P843, DOI 10.1017/S0033291718001496
   Tolin DF, 2006, PSYCHOL BULL, V132, P959, DOI 10.1037/0033-2909.132.6.959
   Udupa K, 2007, J AFFECT DISORDERS, V104, P231, DOI 10.1016/j.jad.2007.04.002
   van den Berk-Clark C, 2018, HEALTH PSYCHOL, V37, P407, DOI 10.1037/hea0000593
   Vitale C, 2009, NAT REV CARDIOL, V6, P532, DOI 10.1038/nrcardio.2009.105
   von Känel R, 2008, PSYCHIAT RES, V158, P363, DOI 10.1016/j.psychres.2006.12.003
   von Känel R, 2011, J CARDIOL, V58, P61, DOI 10.1016/j.jjcc.2011.02.007
   Wang Y, 2014, HEART FAIL REV, V19, P187, DOI 10.1007/s10741-012-9368-1
   Wangelin BC, 2015, DEPRESS ANXIETY, V32, P927, DOI 10.1002/da.22449
   Watts BV, 2012, BRAIN STIMUL, V5, P38, DOI 10.1016/j.brs.2011.02.002
   Weiss T, 2011, GEN HOSP PSYCHIAT, V33, P135, DOI 10.1016/j.genhosppsych.2011.01.002
   Wells A, 2015, COGNITIVE THER RES, V39, P70, DOI 10.1007/s10608-014-9636-6
   Wittbrodt MT, 2021, PSYCHOSOM MED, V83, P969, DOI 10.1097/PSY.0000000000000987
   Wittbrodt MT, 2020, BRAIN STIMUL, V13, P1333, DOI 10.1016/j.brs.2020.07.002
   Xia HJ, 2009, HYPERTENSION, V53, P210, DOI 10.1161/HYPERTENSIONAHA.108.123844
   Yehuda R, 2006, PSYCHONEUROENDOCRINO, V31, P447, DOI 10.1016/j.psyneuen.2005.10.007
   YEHUDA R, 1993, BIOL PSYCHIAT, V34, P18, DOI 10.1016/0006-3223(93)90252-9
   Yoshida T, 2001, J NEUROL SCI, V184, P77, DOI 10.1016/S0022-510X(00)00505-0
   Zandvakili A, 2021, EUR ARCH PSY CLIN N, V271, P29, DOI 10.1007/s00406-020-01172-5
   Zandvakili A, 2019, J AFFECT DISORDERS, V252, P47, DOI 10.1016/j.jad.2019.03.077
   Zhou F, 2019, BIOL PSYCHIAT, V86, P910, DOI 10.1016/j.biopsych.2019.07.007
NR 156
TC 26
Z9 30
U1 3
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1091-4269
EI 1520-6394
J9 DEPRESS ANXIETY
JI Depress. Anxiety
PD OCT
PY 2022
VL 39
IS 10-11
BP 663
EP 674
DI 10.1002/da.23271
EA JUN 2022
PG 12
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 5F5NE
UT WOS:000811597600001
PM 35708302
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Balaji, MP
   Rajeswari, D
AF Balaji, Menaka Priya
   Rajeswari V, Devi
TI Endothelial Dysfunction associated with Diabetes Mellitus linked to
   extracellular signal-regulated kinase and inflammatory pathways
SO RESEARCH JOURNAL OF BIOTECHNOLOGY
LA English
DT Review
DE Endothelial dysfunction; Atherogenesis; Metabolic syndrome; Markers;
   Inflammation
ID GROWTH-FACTOR; RECEPTOR INHIBITION; OXIDATIVE STRESS; RISK-FACTORS;
   ATHEROSCLEROSIS; CHOLESTEROL; GENERATION; CORONARY; OBESITY
AB Endothelial dysfunction and core illnesses are now among the top causes of death on a global scale. Atherogenesis is a prominent risk factor for adverse vascular blockage diseases. People who have hyperglycemia and hyperlipidemia become more prone to developing cerebro-cardiovascular disease and lower limb disorders. Additionally, diabetic metabolic syndrome additionally alters the extracellular signalregulated kinase and immunosignal pathways, as well as the activation of vascular endothelial growth factor, nuclear factors and cell migration all of which contribute to pathogenesis.
   The creation of fibrous and fatty lesions in the intimal layer of an artery is referred to as atherogenesis associated vascular problems. In this study, atherogenic lipid particles, markers and inflammatory signaling pathways related to hyperglycemia and hyperlipidemia complications of atherosclerosis are discussed which will aid in the development of a new strategy to treat the macro-vascular complication for future research and treatment.
C1 [Balaji, Menaka Priya; Rajeswari V, Devi] VIT, Dept Biomed Sci, Sch Biosci & Technol, Vellore 632114, Tamil Nadu, India.
C3 Vellore Institute of Technology (VIT); VIT Vellore
RP Rajeswari, D (corresponding author), VIT, Dept Biomed Sci, Sch Biosci & Technol, Vellore 632114, Tamil Nadu, India.
EM vdevirajeswari@vit.ac.in
RI RAJESWARI, DEVI/T-3738-2019
OI BALAJI, MENAKA PRIYA/0000-0002-0494-6579
CR Abou-Jaoude A.
   Aiello LP, 2000, KIDNEY INT, V58, pS113, DOI 10.1046/j.1523-1755.2000.07718.x
   AMBROSIONI E, 1992, EUR J EPIDEMIOL, V8, P129, DOI 10.1007/BF00145364
   Aronson D, 2002, CARDIOVASC DIABETOL, V1, DOI 10.1186/1475-2840-1-1
   Bansal N, 2015, WORLD J DIABETES, V6, P296, DOI 10.4239/wjd.v6.i2.296
   Behrendt D, 2002, AM J CARDIOL, V90, p40L, DOI 10.1016/S0002-9149(02)02963-6
   Berbudi A, 2020, CURR DIABETES REV, V16, P442, DOI 10.2174/1573399815666191024085838
   Björkegren JLM, 2014, PLOS GENET, V10, DOI 10.1371/journal.pgen.1004201
   Carbone S, 2019, VASC HEALTH RISK MAN, V15, P89, DOI 10.2147/VHRM.S168946
   Ceriello A, 2004, DIABETES, V53, P701, DOI 10.2337/diabetes.53.3.701
   Ceriello A., 2002, EVIDENCE INDEPENDENT
   Chen YQ, 2019, ATHEROSCLEROSIS, V285, P147, DOI 10.1016/j.atherosclerosis.2019.04.211
   Choi E.Y., 2002, UPREGULATION EXTRACE
   Corti R, 2007, ATHEROSCLEROSIS, V190, P106, DOI 10.1016/j.atherosclerosis.2006.02.036
   El Rabey HA, 2017, INDIAN J BIOCHEM BIO, V54, P314
   Endemann DH, 2004, J AM SOC NEPHROL, V15, P1983, DOI 10.1097/01.ASN.0000132474.50966.DA
   Febbraio M, 2001, J CLIN INVEST, V108, P785, DOI 10.1172/JCI200114006
   Feig JE, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0028534
   Frias AB, 2019, J IMMUNOL, V203, P658, DOI 10.4049/jimmunol.1900358
   Godo S, 2017, ARTERIOSCL THROM VAS, V37, pE108, DOI 10.1161/ATVBAHA.117.309813
   Goikuria H, 2018, CYTOKINE GROWTH F R, V39, P62, DOI 10.1016/j.cytogfr.2018.01.006
   Grigsby TJ, 2020, INT J BEHAV MED, V27, P660, DOI 10.1007/s12529-020-09913-5
   Grover SP, 2018, ARTERIOSCL THROM VAS, V38, P709, DOI 10.1161/ATVBAHA.117.309846
   Hadi HAR, 2005, VASC HEALTH RISK MAN, V1, P183
   Hughes CE, 2018, FEBS J, V285, P2944, DOI 10.1111/febs.14466
   Husain S, 1998, CIRCULATION, V97, P716, DOI 10.1161/01.CIR.97.8.716
   Ighodaro OM, 2018, BIOMED PHARMACOTHER, V108, P656, DOI 10.1016/j.biopha.2018.09.058
   Ismail M., 2021, LIPOSOMES DIMERIC AR, P1
   Ito F, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8030072
   Jin D, 2020, FOOD FUNCT, V11, P10617, DOI [10.1039/d0fo01275k, 10.1039/D0FO01275K]
   Kattoor AJ, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8070218
   Kautzky-Willer A, 2016, ENDOCR REV, V37, P278, DOI 10.1210/er.2015-1137
   Kijani S, 2017, PHYSIOL REP, V5, DOI 10.14814/phy2.13334
   Kleinert M, 2018, NAT REV ENDOCRINOL, V14, P140, DOI 10.1038/nrendo.2017.161
   Kühnast S, 2015, EUR HEART J, V36, P39, DOI 10.1093/eurheartj/ehu319
   Li B, 2017, CURR PHARM DESIGN, V23, P1216, DOI 10.2174/1381612822666161230142931
   Liao XH, 2012, CELL METAB, V15, P545, DOI 10.1016/j.cmet.2012.01.022
   Lorkowski S., 2007, NAT PRECED, V1, P2
   Milutinovic A, 2020, BOSNIAN J BASIC MED, V20, P21, DOI 10.17305/bjbms.2019.4320
   Mónica FZ, 2016, ADV PHARMACOL, V77, P1, DOI 10.1016/bs.apha.2016.05.001
   Moreno PR, 2004, J AM COLL CARDIOL, V44, P2293, DOI 10.1016/j.jacc.2004.07.060
   Narindrarangkura P, 2019, LIPIDS HEALTH DIS, V18, DOI 10.1186/s12944-019-1034-3
   Neves KB, 2018, HYPERTENSION, V71, P638, DOI 10.1161/HYPERTENSIONAHA.117.10490
   Nicholls SJ, 2018, J AM COLL CARDIOL, V72, P2012, DOI 10.1016/j.jacc.2018.06.078
   Ning B, 2018, AM J PATHOL, V188, P2936, DOI 10.1016/j.ajpath.2018.08.007
   Nowak WN, 2017, ARTERIOSCL THROM VAS, V37, pE41, DOI 10.1161/ATVBAHA.117.309228
   O'Neill BT, 2019, DIABETES, V68, P556, DOI 10.2337/db18-0416
   Opal SM, 2013, JAMA-J AM MED ASSOC, V309, P1154, DOI 10.1001/jama.2013.2194
   Patel Chetan B, 2006, Diab Vasc Dis Res, V3, P65, DOI 10.3132/dvdr.2006.016
   Poznyak AV, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22137061
   Prentki M, 2020, DIABETES, V69, P279, DOI 10.2337/dbi19-0014
   Protogerou AD, 2011, ATHEROSCLEROSIS, V219, P734, DOI 10.1016/j.atherosclerosis.2011.09.015
   Rajbhandari J, 2021, WORLD J DIABETES, V12, P383, DOI 10.4239/wjd.v12.i4.383
   Ramos JS, 2015, SPORTS MED, V45, P679, DOI 10.1007/s40279-015-0321-z
   Ridker PM, 2014, EUR HEART J, V35, P540, DOI 10.1093/eurheartj/eht398
   Rodríguez C, 2021, AM J RESP CELL MOL, V64, P407, DOI 10.1165/rcmb.2020-0359PS
   Saggini A, 2011, EUR J INFLAMM, V9, P209, DOI 10.1177/1721727X1100900301
   Samsamshariat S, 2019, ADV BIOMED RES-INDIA, V8, DOI 10.4103/abr.abr_126_18
   Sandoo A, 2010, OPEN CARDIOVASC MED, V4, P302, DOI 10.2174/1874192401004010302
   Singh TP, 2015, DIAB MET SYND CLIN R, V9, P223, DOI 10.1016/j.dsx.2015.04.005
   Siracuse J J., 2012, The Pathogenesis of Diabetic Atherosclerosis, P13
   Song PG, 2020, LANCET GLOB HEALTH, V8, pE721, DOI 10.1016/S2214-109X(20)30117-0
   Sproston NR, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.00754
   Sreckovic B, 2017, DIABETES METAB SYND, V11, P179, DOI 10.1016/j.dsx.2016.08.026
   Srividhya E., 2019, 2019 1st International Conference on Advances in Information Technology (ICAIT). Proceedings, P217, DOI 10.1109/ICAIT47043.2019.8987391
   Sun XJ, 2017, J BIOL CHEM, V292, P12339, DOI 10.1074/jbc.M117.779108
   Thomas DD, 2019, J ENDOCR SOC, V3, P1727, DOI 10.1210/js.2019-00065
   Tie CM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0142430
   Tong YQ, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/7308736
   Torella D, 2018, DIABETES, V67, P2554, DOI 10.2337/db17-1434
   Vinué A, 2017, DIABETOLOGIA, V60, P1801, DOI 10.1007/s00125-017-4330-3
   Virella Gabriel, 2012, Front Endocrinol (Lausanne), V3, P76, DOI 10.3389/fendo.2012.00076
   Wang N, 2018, BIOMED PHARMACOTHER, V108, P1825, DOI 10.1016/j.biopha.2018.09.143
   Wickramasinghe ASD, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/2920530
   Witkowski M, 2022, CARDIOVASC RES, V118, P2367, DOI 10.1093/cvr/cvab263
   Yahagi K, 2017, ARTERIOSCL THROM VAS, V37, P191, DOI 10.1161/ATVBAHA.116.306256
   Yamagishi S, 2011, J CARDIOL, V57, P257, DOI 10.1016/j.jjcc.2011.01.011
   Yurdagul A, 2018, FRONT CARDIOVASC MED, V4, DOI 10.3389/fcvm.2017.00086
   Zeibig Stephan, 2019, Cell Physiol Biochem, V52, P681, DOI 10.33594/000000048
   Zhao NS, 2018, AGING-US, V10, P2695, DOI 10.18632/aging.101580
   Zirnheld Arin Lee, 2013
NR 81
TC 2
Z9 2
U1 0
U2 0
PU RESEARCH JOURNAL BIOTECHNOLOGY
PI INDORE
PA SECTOR A-80, SCHEME NO 54, VIJAY NAGAR, A B ROAD, INDORE, 452 010 MP,
   INDIA
SN 2278-4535
J9 RES J BIOTECHNOL
JI Res. J. Biotechnol.
PD JAN
PY 2023
VL 18
IS 1
BP 135
EP 146
PG 12
WC Biotechnology & Applied Microbiology
WE Emerging Sources Citation Index (ESCI)
SC Biotechnology & Applied Microbiology
GA 7B2CA
UT WOS:000898947000018
DA 2025-06-11
ER

PT J
AU Schinzari, F
   Tesauro, M
   Rovella, V
   Di Daniele, N
   Gentileschi, P
   Mores, N
   Campia, U
   Cardillo, C
AF Schinzari, Francesca
   Tesauro, Manfredi
   Rovella, Valentina
   Di Daniele, Nicola
   Gentileschi, Paolo
   Mores, Nadia
   Campia, Umberto
   Cardillo, Carmine
TI Rho-kinase inhibition improves vasodilator responsiveness during
   hyperinsulinemia in the metabolic syndrome
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE fasudil; endothelium-dependent dilation; endothelium-ndependent
   dilation; insulin; obesity
ID SMOOTH-MUSCLE-CELLS; INSULIN-RESISTANCE; NITRIC-OXIDE; IN-VIVO;
   ENDOTHELIAL DYSFUNCTION; SIGNALING PATHWAYS; HUMANS; ACTIVATION;
   PHOSPHATASE; PREVENTS
AB Schinzari F, Tesauro M, Rovella V, Di Daniele N, Gentileschi P, Mores N, Campia U, Cardillo C. Rho-kinase inhibition improves vasodilator responsiveness during hyperinsulinemia in the metabolic syndrome. Am J Physiol Endocrinol Metab 303: E806-E811, 2012. First published July 24, 2012; doi:10.1152/ajpendo.00206.2012.-In patients with the metabolic syndrome (MetS), the facilitatory effect of insulin on forearm vasodilator responsiveness to different stimuli is impaired. Whether the RhoA/Rho kinase (ROCK) pathway is involved in this abnormality is unknown. We tested the hypotheses that, in MetS patients, ROCK inhibition with fasudil restores insulin-stimulated vasodilator reactivity and that oxidative stress plays a role in this mechanism. Endothelium-dependent and -independent forearm blood flow responses to acetylcholine (ACh) and sodium nitroprusside (SNP), respectively, were assessed in MetS patients (n = 8) and healthy controls (n = 5) before and after the addition of fasudil (200 mu g/min) to an intra- arterial infusion of insulin (0.1 mU/kg/min). In MetS patients (n = 5), fasudil was also infused without hyperinsulinemia. The possible involvement of oxidative stress in the effect of fasudil during hyperinsulinemia was investigated in MetS patients (n = 5) by infusing vitamin C (25 mg/min). In MetS patients, compared with saline, fasudil enhanced endothelium-dependent and - independent vasodilator responses during insulin infusion (P < 0.001 and P = 0.008, respectively), but not in the absence of hyperinsulinemia (P = 0.25 and P = 0.13, respectively). By contrast, fasudil did not affect vasoreactivity to ACh and SNP during hyperinsulinemia in controls (P = 0.11 and P = 0.56, respectively). In MetS patients, fasudil added to insulin and vitamin C did not further enhance vasodilation to ACh and SNP (P = 0.15 and P = 0.43, respectively). In the forearm circulation of patients with the MetS, ROCK inhibition by fasudil improves endothelium-dependent and - independent vasodilator responsiveness during hyperinsulinemia; increased oxidative stress seems to be involved in the pathophysiology of this phenomenon.
C1 [Schinzari, Francesca; Cardillo, Carmine] Catholic Univ Med Sch, Dept Internal Med, Rome, Italy.
   [Campia, Umberto] Catholic Univ Med Sch, Dept Pharmacol, Rome, Italy.
   [Tesauro, Manfredi; Rovella, Valentina; Di Daniele, Nicola] Univ Roma Tor Vergata, Dept Internal Med, Rome, Italy.
   [Gentileschi, Paolo] Univ Roma Tor Vergata, Dept Surg, Rome, Italy.
   [Campia, Umberto] Northwestern Univ, Div Cardiol, Feinberg Sch Med, Chicago, IL 60611 USA.
C3 Catholic University of the Sacred Heart; Catholic University of the
   Sacred Heart; University of Rome Tor Vergata; University of Rome Tor
   Vergata; Northwestern University; Feinberg School of Medicine
RP Cardillo, C (corresponding author), Univ Cattolica Sacro Cuore, Ist Patol Speciale Med & Semeiot Med, Largo Gemelli 8, I-00168 Rome, Italy.
EM carmine.cardillo@rm.unicatt.it
RI Rovella, Valentina/AAB-9727-2019; schinzari, francesca/AAB-9982-2019
OI Gentileschi, Paolo/0009-0007-3068-9848; MORES,
   Nadia/0000-0002-4197-0914; Cardillo, Carmine/0000-0001-5182-3005;
   Rovella, Valentina/0000-0002-3311-486X
FU Fondi d'Ateneo grants from the Universita Cattolica del Sacro Cuore;
   Fondazione Roma grant; National Heart, Lung, and Blood Institute grant
   [K12-HL-083790]
FX This work was partially supported by Fondi d'Ateneo grants from the
   Universita Cattolica del Sacro Cuore to C. Cardillo and by a Fondazione
   Roma grant to M. Tesauro. U. Campia is supported by a National Heart,
   Lung, and Blood Institute grant (K12-HL-083790).
CR Beckman JA, 2001, CIRCULATION, V103, P1618, DOI 10.1161/01.CIR.103.12.1618
   Begum N, 2002, J BIOL CHEM, V277, P6214, DOI 10.1074/jbc.M110508200
   Begum N, 2000, MOL ENDOCRINOL, V14, P1365, DOI 10.1210/me.14.9.1365
   Büssemaker E, 2007, AM J PHYSIOL-HEART C, V293, pH541, DOI 10.1152/ajpheart.00770.2006
   Cavarape A, 2003, NEPHROL DIAL TRANSPL, V18, P1764, DOI 10.1093/ndt/gfg291
   Cavarape A, 2003, J AM SOC NEPHROL, V14, P37, DOI 10.1097/01.ASN.0000039568.93355.85
   Chen H, 2006, AM J PHYSIOL-HEART C, V290, pH137, DOI 10.1152/ajpheart.00768.2005
   Chun KH, 2011, AM J PHYSIOL-ENDOC M, V300, pE536, DOI 10.1152/ajpendo.00538.2010
   Clark MG, 2008, AM J PHYSIOL-ENDOC M, V295, pE732, DOI 10.1152/ajpendo.90477.2008
   Davies SP, 2000, BIOCHEM J, V351, P95, DOI 10.1042/0264-6021:3510095
   Evans JL, 2005, ANTIOXID REDOX SIGN, V7, P1040, DOI 10.1089/ars.2005.7.1040
   Furukawa N, 2005, CELL METAB, V2, P119, DOI 10.1016/j.cmet.2005.06.011
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Jackson TS, 1998, CIRC RES, V83, P916
   Jin LM, 2004, AM J PHYSIOL-HEART C, V287, pH1495, DOI 10.1152/ajpheart.01006.2003
   Kahn BB, 2000, J CLIN INVEST, V106, P473, DOI 10.1172/JCI10842
   Kanda T, 2005, FASEB J, V19, P169, DOI 10.1096/fj.05-4197fje
   Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213
   Kishi T, 2005, CIRCULATION, V111, P2741, DOI 10.1161/CIRCULATIONAHA.104.510248
   Lee DH, 2009, J BIOL CHEM, V284, P11776, DOI 10.1074/jbc.C900014200
   Liu PY, 2007, J AM COLL CARDIOL, V49, P1619, DOI 10.1016/j.jacc.2006.12.043
   Loirand G, 2006, CIRC RES, V98, P322, DOI 10.1161/01.RES.0000201960.04223.3c
   Masumoto A, 2001, HYPERTENSION, V38, P1307, DOI 10.1161/hy1201.096541
   Ming XF, 2002, MOL CELL BIOL, V22, P8467, DOI 10.1128/MCB.22.24.8467-8477.2002
   Mohri M, 2003, J AM COLL CARDIOL, V41, P15, DOI 10.1016/S0735-1097(02)02632-3
   Nohria A, 2006, CIRC RES, V99, P1426, DOI 10.1161/01.RES.0000251668.39526.c7
   Sandu OA, 2000, DIABETES, V49, P2178, DOI 10.2337/diabetes.49.12.2178
   Satoh K, 2011, AM J PHYSIOL-HEART C, V301, pH287, DOI 10.1152/ajpheart.00327.2011
   Schinzari F, 2010, AM J PHYSIOL-ENDOC M, V299, pE947, DOI 10.1152/ajpendo.00426.2010
   Soga J, 2011, ARTERIOSCL THROM VAS, V31, P2353, DOI 10.1161/ATVBAHA.111.227892
   Tesauro M, 2005, CIRCULATION, V112, P2986, DOI 10.1161/CIRCULATIONAHA.105.553883
NR 31
TC 15
Z9 17
U1 0
U2 2
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD SEP
PY 2012
VL 303
IS 6
BP E806
EP E811
DI 10.1152/ajpendo.00206.2012
PG 6
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 009BB
UT WOS:000308999200012
PM 22829585
OA Green Published
DA 2025-06-11
ER

PT J
AU Nadalin, S
   Pavlic, SD
   Peitl, V
   Karlovic, D
   Zatkovic, L
   Ristic, S
   Buretic-Tomljanovic, A
   Jakovac, H
AF Nadalin, Sergej
   Pavlic, Sanja Devic
   Peitl, Vjekoslav
   Karlovic, Dalibor
   Zatkovic, Lena
   Ristic, Smiljana
   Buretic-Tomljanovic, Alena
   Jakovac, Hrvoje
TI Association between Insertion-Deletion Polymorphism of the
   Angiotensin-Converting Enzyme Gene and Treatment Response to
   Antipsychotic Medications: A Study of Antipsychotic-Naive First-Episode
   Psychosis Patients and Nonadherent Chronic Psychosis Patients
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE angiotensin-converting enzyme (ACE); antipsychotic medication;
   polymorphism; insertion; deletion; treatment response
ID NEGATIVE-SYNDROME-SCALE; CEREBROSPINAL-FLUID; METABOLIC SYNDROME;
   REPLACEMENT THERAPY; I/D POLYMORPHISM; 5-FACTOR MODEL; KININASE-II;
   SCHIZOPHRENIA; SUSCEPTIBILITY; VALIDATION
AB We investigated whether a functional insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) influenced antipsychotic treatment. At baseline, and after 8 weeks of treatment with various antipsychotic medications, we assessed patients' Positive and Negative Syndrome Scale (PANSS) scores, PANSS factors, and metabolic-syndrome-related parameters (fasting plasma lipid and glucose levels, and body mass index). A total of 186 antipsychotic-naive first-episode psychosis patients or nonadherent chronic psychosis individuals (99 males and 87 females) were genotyped by polymerase chain reaction analysis. The ACE-I/D polymorphism was significantly associated with changes in PANSS psychopathology only (p < 0.05). Compared to ACE-II homozygous males, ACE-DD homozygous and ACE-ID heterozygous males manifested significantly greater decreases in PANSS positive score, PANSS excitement factor, and PANSS cognitive factor. ACE-DD homozygous females manifested higher decreases in PANSS depression factor compared to ACE-II homozygous and ACE-ID heterozygous females. The polymorphism's effect size was estimated as moderate to strong, while its contribution to the PANSS psychopathology ranged from similar to 5.4 to 8.7%, with the lowest contribution observed for PANSS positive score changes and the highest for PANSS depressive factor changes. Our results indicate that ACE-I/D polymorphism had a statistically significant but weak gender-specific impact on psychopathology data, and showed no association between ACE-I/D polymorphism and metabolic-syndrome-related parameters.
C1 [Nadalin, Sergej] Gen Hosp Dr Josip Ben Evi, Dept Psychiat, Slavonski Brod 35000, Croatia.
   [Nadalin, Sergej; Peitl, Vjekoslav; Karlovic, Dalibor] Catholic Univ Croatia, Sch Med, Zagreb 10000, Croatia.
   [Pavlic, Sanja Devic; Ristic, Smiljana; Buretic-Tomljanovic, Alena] Univ Rijeka, Fac Med, Dept Med Biol & Genet, Rijeka 51000, Croatia.
   [Peitl, Vjekoslav; Karlovic, Dalibor] Sestre Milosrdnice Univ Hosp Ctr, Dept Psychiat, Zagreb 10000, Croatia.
   [Zatkovic, Lena] Hosp Pharm, Clin Hosp Ctr Rijeka, Rijeka 51000, Croatia.
   [Jakovac, Hrvoje] Univ Rijeka, Fac Med, Dept Physiol Immunol & Pathophysiol, Rijeka 51000, Croatia.
C3 University of Rijeka; University of Zagreb; University of Rijeka;
   University of Rijeka
RP Jakovac, H (corresponding author), Univ Rijeka, Fac Med, Dept Physiol Immunol & Pathophysiol, Rijeka 51000, Croatia.
EM hrvoje.jakovac@medri.uniri.hr
RI Buretic-Tomljanovic, Alena/S-3985-2018; Ristić, Smiljana/R-5713-2018;
   Nadalin, Sergej/R-6189-2018; Jakovac, Hrvoje/P-6514-2018; Peitl,
   Vjekoslav/Q-9358-2018; Devic Pavlic, Sanja/Q-7922-2018
OI Peitl, Vjekoslav/0000-0003-4163-6411; Devic Pavlic,
   Sanja/0000-0001-8440-1722
FU University of Rijeka, Croatia [17.07.2.1.10, uniri-biomed-18-251,
   uniri-biomed-18-187]
FX This research was supported by grants 17.07.2.1.10, uniri-biomed-18-251,
   and uniri-biomed-18-187 from the University of Rijeka, Croatia. The
   University had no further role in the study design; data collection,
   analysis, or interpretation; or the decision to submit this paper for
   publication.
CR Alvarez-Aguilar C, 2007, EXP MOL MED, V39, P327, DOI 10.1038/emm.2007.36
   Anderson A, 2015, PSYCHIAT RES, V225, P283, DOI 10.1016/j.psychres.2014.12.025
   [Anonymous], COMPUTATION EFFECT S
   Barth C, 2015, FRONT NEUROSCI-SWITZ, V9, DOI 10.3389/fnins.2015.00037
   BECKMANN H, 1984, BIOL PSYCHIAT, V19, P679
   Bergovec M, 2008, WIEN KLIN WOCHENSCHR, V120, P684, DOI 10.1007/s00508-008-1065-7
   Carli M, 2021, PHARMACEUTICALS-BASE, V14, DOI 10.3390/ph14030238
   Cuthbert BN, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-126
   Fawaz CS, 2009, BMC NEUROSCI, V10, DOI 10.1186/1471-2202-10-96
   Fister K, 2012, COLLEGIUM ANTROPOL, V36, P201, DOI 10.5671/ca.2012361s.201
   Gadelha A, 2015, SCHIZOPHR RES, V164, P109, DOI 10.1016/j.schres.2015.01.044
   Giesbrecht CJ, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0151648
   Goh KK, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23137092
   Heath E, 2018, EUR J NEUROSCI, V47, P1159, DOI 10.1111/ejn.13750
   Herrera-Estrella M, 2005, BMC PSYCHIATRY, V5, DOI 10.1186/1471-244X-5-22
   Hui L, 2015, HUM PSYCHOPHARM CLIN, V30, P100, DOI 10.1002/hup.2460
   Hui L, 2014, HUM PSYCHOPHARM CLIN, V29, P274, DOI 10.1002/hup.2396
   Jacobs E, 2011, J NEUROSCI, V31, P5286, DOI 10.1523/JNEUROSCI.6394-10.2011
   Jenkins TA, 1997, J NEUROCHEM, V68, P1304
   Jenkins TA, 1996, ADV EXP MED BIOL, V396, P93
   Jiang JD, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071343
   Mazaheri H, 2015, IRAN J PUBLIC HEALTH, V44, P369
   Milanovic SM, 2012, COLLEGIUM ANTROPOL, V36, P113
   Misiak B, 2015, COMPR PSYCHIAT, V58, P146, DOI 10.1016/j.comppsych.2014.11.024
   Mittal G, 2011, CHINESE MED J-PEKING, V124, P45, DOI 10.3760/cma.j.issn.0366-6999.2011.01.009
   Nadalin S, 2020, BIOMED REP, V13, DOI 10.3892/br.2020.1365
   Nadalin S, 2017, J NEURAL TRANSM, V124, P511, DOI 10.1007/s00702-016-1670-y
   Nadalin S, 2015, PSYCHIAT RES, V227, P71, DOI 10.1016/j.psychres.2015.03.014
   Nadalin S, 2012, PSYCHIAT GENET, V22, P267, DOI 10.1097/YPG.0b013e3283518524
   Nagamine Takahiko, 2008, Neuropsychiatr Dis Treat, V4, P289
   Nani JV, 2020, INT J NEUROPSYCHOPH, V23, P721, DOI 10.1093/ijnp/pyaa050
   National Library of Medicine, NCBI NLM NIH
   Nawaz SK, 2009, BIOCHEM MEDICA, V19, P36
   Niu WQ, 2010, ENDOCR J, V57, P431, DOI 10.1507/endocrj.K09E-360
   Obata T, 2008, TOXICOLOGY, V250, P96, DOI 10.1016/j.tox.2008.06.005
   Del Rio JP, 2018, FRONT PUBLIC HEALTH, V6, DOI 10.3389/fpubh.2018.00141
   Paderina DZ, 2022, GENES-BASEL, V13, DOI 10.3390/genes13081312
   Postolache TT, 2019, AM J MED GENET B, V180, P186, DOI 10.1002/ajmg.b.32712
   RIGAT B, 1990, J CLIN INVEST, V86, P1343, DOI 10.1172/JCI114844
   Riordan JF, 2003, GENOME BIOL, V4, DOI 10.1186/gb-2003-4-8-225
   Ristic S, 2006, MULT SCLER, V12, P360, DOI 10.1191/135248506ms1305sr
   Sanada M, 2001, J AM COLL CARDIOL, V37, P1529, DOI 10.1016/S0735-1097(01)01191-3
   Servonnet A, 2017, NEUROPHARMACOLOGY, V123, P10, DOI 10.1016/j.neuropharm.2017.05.015
   SHANMUGAM V, 1993, PCR METH APPL, V3, P120
   Song GG, 2015, J RENIN-ANGIO-ALDO S, V16, P434, DOI 10.1177/1470320313495909
   Sumino H, 2003, HYPERTENS RES, V26, P53
   Trieu BH, 2022, SCIENCE, V375, P1177, DOI 10.1126/science.abl5130
   van der Gaag M, 2006, SCHIZOPHR RES, V85, P280, DOI 10.1016/j.schres.2006.03.021
   WAHLBECK K, 1993, SCHIZOPHR RES, V9, P77, DOI 10.1016/0920-9964(93)90013-9
   Wahlbeck K, 1998, SCHIZOPHRENIA BULL, V24, P391, DOI 10.1093/oxfordjournals.schbul.a033334
   Wallwork RS, 2012, SCHIZOPHR RES, V137, P246, DOI 10.1016/j.schres.2012.01.031
   Wincewicz D, 2017, PHARMACOPSYCHIATRY, V50, P233, DOI 10.1055/s-0043-112345
   Zhong Weiqiang, 2015, J Renin Angiotensin Aldosterone Syst, V16, pNP35, DOI 10.1177/1470320314566019
NR 53
TC 3
Z9 3
U1 0
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2022
VL 23
IS 20
AR 12180
DI 10.3390/ijms232012180
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 5P0VK
UT WOS:000872879100001
PM 36293037
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Graybeal, AJ
   Brandner, CF
   Henderson, A
   Aultman, RA
   Vallecillo-Bustos, A
   Newsome, TA
   Stanfield, D
   Stavres, J
AF Graybeal, Austin J.
   Brandner, Caleb F.
   Henderson, Alex
   Aultman, Ryan A.
   Vallecillo-Bustos, Anabelle
   Newsome, Ta'Quoris A.
   Stanfield, Diavion
   Stavres, Jon
TI Associations between eating behaviors and metabolic syndrome severity in
   young adults
SO EATING BEHAVIORS
LA English
DT Article
DE Behavioral interventions; Emotional eating; Obesity; Metabolic syndrome;
   Health disparities; Eating disorders
ID CARDIOVASCULAR RISK; ENERGY-INTAKE; PREVALENCE; DEPRESSION; STATE; MASS;
   BMI
AB Metabolic syndrome (MetS), a precursor to cardiovascular disease and type II diabetes, is rapidly increasing in young adults. Accordingly, earlier interventions aimed at combating the onset of MetS in young adults are required. However, current behavioral interventions have failed to consider the eating behaviors that precede disease development, likely contributing to the consistently high failure rates of these interventions. The purpose of this cross-sectional study was to evaluate the associations between eating behaviors and MetS severity (MetSindex) in a sample of young adults. A sample of 104 (non-Hispanic White: 45; non-Hispanic Black: 49; Hispanic White: 5; Asian: 5) young adult (age: 23.1 +/- 4.4) males and females (F:61, M:43) completed anthropometric, blood pressure, blood glucose, and blood lipid assessments; each of which were used to calculate a continuous MetSindex score. Participants also completed the revised version of the 18-item Three-factor Eating Questionnaire to measure emotional eating (EmE), uncontrolled eating (UE), and cognitive restraint (CR). EmE was positively associated with MetSindex for young adult females (p = 0.033) and non-Hispanic Black participants (p = 0.050), but not male (p = 0.506) or non-Hispanic White participants (p = 0.558). Additionally, MetSindex was greater in the highest EmE tertile compared to the lowest EmE tertile for the total sample (p = 0.037) and young adult females (p = 0.015). UE and CR were not associated with MetSindex. These data suggest a potential link between EmE and MetS severity in young adults, and that behavioral interventions aimed at MetS prevention should focus on treating the underlying EmE behaviors common in young adults, particularly for young female and Black adults at the greatest risk.
C1 [Graybeal, Austin J.; Brandner, Caleb F.; Henderson, Alex; Aultman, Ryan A.; Vallecillo-Bustos, Anabelle; Newsome, Ta'Quoris A.; Stanfield, Diavion; Stavres, Jon] Univ Southern Mississippi, Sch Kinesiol & Nutr, Hattiesburg, MS 39406 USA.
   [Graybeal, Austin J.] Univ Southern Mississippi, Coll Educ & Human Sci, Sch Kinesiol & Nutr, Hattiesburg, MS 39406 USA.
C3 University of Southern Mississippi; University of Southern Mississippi
RP Graybeal, AJ (corresponding author), Univ Southern Mississippi, Coll Educ & Human Sci, Sch Kinesiol & Nutr, Hattiesburg, MS 39406 USA.
EM austin.graybeal@usm.edu
RI Stavres, Jon/JTS-7791-2023; Graybeal, Austin/AAO-5501-2021
OI Graybeal, Austin/0000-0003-4520-9230
FU University of Southern Mississippi
FX Funding was provided by the University of Southern Mississippi start-up
   funds for AJG and JS. There are no other funding sources report.
CR Albert PR, 2015, J PSYCHIATR NEUROSCI, V40, P219, DOI 10.1503/jpn.150205
   Barnes R. D., 2011, Primary Care Companion for CNS Disorders, V13
   Blundell JE, 2012, BRIT J NUTR, V107, P445, DOI 10.1017/S0007114511003138
   Bower KM, 2014, PREV MED, V58, P33, DOI 10.1016/j.ypmed.2013.10.010
   Cardel MI, 2018, PSYCHONEUROENDOCRINO, V90, P141, DOI 10.1016/j.psyneuen.2018.02.014
   Dale RA, 2008, ANN PHARMACOTHER, V42, P633, DOI 10.1345/aph.1K688
   de Lauzon B, 2004, J NUTR, V134, P2372
   Diggins A, 2015, EAT BEHAV, V19, P188, DOI 10.1016/j.eatbeh.2015.09.006
   Barak RE, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18041744
   Ford ES, 2008, DIABETES CARE, V31, P1898, DOI 10.2337/dc08-0423
   French SA, 2012, APPETITE, V59, P541, DOI 10.1016/j.appet.2012.07.001
   Galmiche M, 2019, AM J CLIN NUTR, V109, P1402, DOI 10.1093/ajcn/nqy342
   Graybeal AJ, 2023, NUTR RES, V112, P1, DOI 10.1016/j.nutres.2023.02.003
   Graybeal AJ, 2023, BRIT J NUTR, V130, P1077, DOI 10.1017/S0007114523000090
   Graybeal AJ, 2023, BRIT J NUTR, V130, P525, DOI 10.1017/S0007114522003488
   Graybeal AJ, 2022, NUTRITION, V103-104, DOI 10.1016/j.nut.2022.111815
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Gurka MJ, 2016, PSYCHONEUROENDOCRINO, V68, P82, DOI 10.1016/j.psyneuen.2016.02.030
   Gurka MJ, 2014, METABOLISM, V63, P218, DOI 10.1016/j.metabol.2013.10.006
   Halsey LG, 2019, BIOL LETTERS, V15, DOI 10.1098/rsbl.2019.0174
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Hudson JI, 2010, AM J CLIN NUTR, V91, P1568, DOI 10.3945/ajcn.2010.29203
   Jiang FS, 2014, DIABETES TECHNOL THE, V16, P363, DOI 10.1089/dia.2013.0289
   Langeveld M, 2015, OBESITY, V23, P1529, DOI 10.1002/oby.21146
   Lee DK, 2016, KOREAN J ANESTHESIOL, V69, P555, DOI 10.4097/kjae.2016.69.6.555
   Lee JJ, 2017, AM J MED, V130, P958, DOI 10.1016/j.amjmed.2017.01.044
   Lovan P, 2024, J AM COLL HEALTH, V72, P2567, DOI 10.1080/07448481.2022.2119402
   Mallorquí-Bagué N, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-88298-1
   Michopoulos V, 2015, APPETITE, V91, P129, DOI 10.1016/j.appet.2015.03.036
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Neumark-Sztainer D, 2011, J AM DIET ASSOC, V111, P1004, DOI 10.1016/j.jada.2011.04.012
   Ofer K, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000014712
   Oh YH, 2021, J CLIN MED, V10, DOI 10.3390/jcm10040745
   Poobalan AS, 2014, HEALTH PSYCHOL BEHAV, V2, P909, DOI 10.1080/21642850.2014.931232
   Radin RM, 2020, HEALTH PSYCHOL, V39, P147, DOI 10.1037/hea0000807
   Reicks M, 2014, J AM COLL NUTR, V33, P315, DOI 10.1080/07315724.2014.887485
   Ryan DH, 2017, CURR OBES REP, V6, P187, DOI 10.1007/s13679-017-0262-y
   Rzehak P, 2007, EUR J EPIDEMIOL, V22, P665, DOI 10.1007/s10654-007-9167-5
   Rudakoff LCS, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.1006018
   Stavres J, 2023, FRONT PHYSIOL, V14, DOI 10.3389/fphys.2023.1212775
   STUNKARD AJ, 1985, J PSYCHOSOM RES, V29, P71, DOI 10.1016/0022-3999(85)90010-8
   van Strien T, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1000-x
   Ward ZJ, 2019, NEW ENGL J MED, V381, P2440, DOI 10.1056/NEJMsa1909301
NR 43
TC 8
Z9 8
U1 1
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1471-0153
EI 1873-7358
J9 EAT BEHAV
JI Eat. Behav.
PD DEC
PY 2023
VL 51
AR 101821
DI 10.1016/j.eatbeh.2023.101821
EA OCT 2023
PG 6
WC Psychology, Clinical; Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA X1SW4
UT WOS:001096327500001
PM 37866123
DA 2025-06-11
ER

PT J
AU Simjanoski, M
   Patel, S
   De Boni, R
   Balanzá-Martínez, V
   Frey, BN
   Minuzzi, L
   Kapczinski, F
   Cardoso, TD
AF Simjanoski, Mario
   Patel, Swara
   De Boni, Raquel
   Balanza-Martinez, Vicent
   Frey, Benicio N.
   Minuzzi, Luciano
   Kapczinski, Flavio
   Cardoso, Taiane de Azevedo
TI Lifestyle interventions for bipolar disorders: A systematic review and
   meta-analysis
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Bipolar disorder; Lifestyle interventions; Systematic review;
   Meta-analysis; RCT; Lifestyle psychiatry; Lifestyle medicine; Diet;
   Exercise; Substance use; Stress; Sleep; Social relationships
ID QUALITY-OF-LIFE; SLEEP DISTURBANCE; METABOLIC SYNDROME; SOCIAL SUPPORT;
   EXERCISE; PSYCHOEDUCATION; DEPRESSION; RISK; NUTRITION; SYMPTOMS
AB This review and meta-analysis aimed to describe the existing literature on interventions for bipolar disorder (BD) targeting the 6 pillars of Lifestyle Psychiatry: diet, physical activity (PA), substance use (SU), sleep, stress management, and social relationships (SR). Randomized Controlled Trials that examined the efficacy of lifestyle interventions targeting improvement in depressive/(hypo)manic symptom severity, lifestyle patterns, func-tioning, quality of life, and/or circadian rhythms were included. The systematic review included 18 studies, while the meta-analysis included studies targeting the same lifestyle domains and outcomes. Sleep (n = 10), PA (n = 9), and diet (n = 8) were the most targeted domains, while SU, SM and SR were least targeted (n = 4 each). Combined diet and PA interventions led to significant improvements in depressive symptoms (SMD:-0.46; 95% CI:-0.88,-0.04; p = 0.03), and functioning (SMD:-0.47; 95%CI:-0.89,-0.05; p = 0.03). Sleep interventions also led to significant improvements in depressive symptoms (SMD:-0.80; 95%CI:-1.21,-0.39; p < 0.01). Future research should focus on developing more multidimensional lifestyle interventions for a potentially greater impact on clinical and functional outcomes of BD.
C1 [Simjanoski, Mario; Frey, Benicio N.; Minuzzi, Luciano; Kapczinski, Flavio] McMaster Univ, Neurosci Grad Program, 1280 Main St West, Hamilton, ON, Canada.
   [Simjanoski, Mario; Frey, Benicio N.; Minuzzi, Luciano; Kapczinski, Flavio; Cardoso, Taiane de Azevedo] McMaster Univ, Dept Psychiat & Behav Neurosci, 1280 Main St West, Hamilton, ON, Canada.
   [Patel, Swara; Cardoso, Taiane de Azevedo] McMaster Univ, Sch Interdisciplinary Sci, Life Sci Program, 1280 Main St West, Hamilton, ON, Canada.
   [De Boni, Raquel] Oswaldo Cruz Fdn FIOCRUZ, Inst Sci & Technol Commun & Informat Hlth ICICT, 4365 Manguinhos, Rio De Janeiro, Brazil.
   [Balanza-Martinez, Vicent; Minuzzi, Luciano] Univ Valencia, CIBERSAM, Dept Med, Teaching Unit Psychiat & Psychol Med, Av Blasco Ibanez 13, Valencia, Spain.
   [Frey, Benicio N.] St Josephs Healthcare, Womens Hlth Concerns Clin, 100 West 5th St, Hamilton, ON, Canada.
   [Frey, Benicio N.] St Josephs Healthcare, Mood Disorders Program, 100 West 5th St, Hamilton, ON, Canada.
   [Kapczinski, Flavio] Inst Nacl Ciencia & Tecnol Translac Med INCT TM, Porto Alegre, Brazil.
C3 McMaster University; McMaster University; McMaster University; Fundacao
   Oswaldo Cruz; University of Valencia; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERSAM
RP Simjanoski, M (corresponding author), McMaster Univ, Neurosci Grad Program, 1280 Main St West, Hamilton, ON, Canada.
EM simjanom@mcmaster.ca
RI Frey, Benicio/AAJ-8212-2021; Balanzá-Martínez, Vicent/C-3073-2011;
   Minuzzi, Luciano/ABH-3481-2020; Kapczinski, Flavio/D-3175-2013
OI Balanza-Martinez, Vicent/0000-0001-7772-7396; Simjanoski,
   Mario/0000-0002-3139-9734; Kapczinski, Flavio/0000-0001-8738-856X
CR Melo MCA, 2016, J AFFECT DISORDERS, V198, P32, DOI 10.1016/j.jad.2016.03.004
   Anmella G, 2022, BIPOLAR DISORD, V24, P580, DOI 10.1111/bdi.13243
   Archer T, 2014, CNS NEUROL DISORD-DR, V13, P1640
   Arya S, 2021, JAMA SURG, V156, P789, DOI 10.1001/jamasurg.2021.0546
   Balanzá-Martínez V, 2021, REV PSIQUIATR SALUD, V14, P16, DOI 10.1016/j.rpsm.2020.07.003
   Balanzá-Martínez V, 2020, CURR PHARM DESIGN, V26, P2353, DOI 10.2174/1381612826666200318152530
   Bauer IE, 2016, J PSYCHIATR RES, V74, P1, DOI 10.1016/j.jpsychires.2015.12.006
   Beyer JL, 2016, PSYCHIAT CLIN N AM, V39, P75, DOI 10.1016/j.psc.2015.10.003
   Bridi KPB, 2018, TRENDS PSYCHIATR PSY, V40, P318
   Castro R, 2022, FRONT PUBLIC HEALTH, V9, DOI 10.3389/fpubh.2021.735624
   Cervera-Martínez J, 2021, J AFFECT DISORDERS, V295, P173, DOI 10.1016/j.jad.2021.08.020
   Cohen AN, 2004, J AFFECT DISORDERS, V82, P143, DOI 10.1016/j.jad.2003.10.008
   Colom F, 2003, J CLIN PSYCHIAT, V64, P1101, DOI 10.4088/JCP.v64n0917
   De Boni RB, 2021, PREV MED, V150, DOI 10.1016/j.ypmed.2021.106718
   Depp CA, 2015, J AFFECT DISORDERS, V174, P23, DOI 10.1016/j.jad.2014.10.053
   Esaki Y, 2020, BIPOLAR DISORD, V22, P739, DOI 10.1111/bdi.12912
   Fiedorowicz JG, 2008, ANN CLIN PSYCHIATRY, V20, P131, DOI 10.1080/10401230802177722
   Firth J, 2020, WORLD PSYCHIATRY, V19, P360, DOI 10.1002/wps.20773
   Firth J, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00597
   Frank E, 1997, BIOL PSYCHIAT, V41, P1165, DOI 10.1016/S0006-3223(96)00241-7
   Frank E, 2015, BIPOLAR DISORD, V17, P424, DOI 10.1111/bdi.12283
   Frey BN, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.20213
   Gee B, 2019, SLEEP MED REV, V43, P118, DOI 10.1016/j.smrv.2018.09.004
   Gillhoff Kornelia, 2010, Prim Care Companion J Clin Psychiatry, V12, DOI 10.4088/PCC.09m00906yel
   Goracci A, 2016, J AFFECT DISORDERS, V196, P20, DOI 10.1016/j.jad.2016.02.034
   Harvey AG, 2015, SLEEP MED CLIN, V10, P101, DOI 10.1016/j.jsmc.2014.11.005
   Harvey AG, 2015, J CONSULT CLIN PSYCH, V83, P564, DOI 10.1037/a0038655
   Harvey AG, 2009, CLIN PSYCHOL-SCI PR, V16, P256, DOI 10.1111/j.1468-2850.2009.01164.x
   Henriksen TEG, 2016, BIPOLAR DISORD, V18, P221, DOI 10.1111/bdi.12390
   Higgins JPT, 2011, BMJ-BRIT MED J, V343, DOI 10.1136/bmj.d5928
   Husain MI, 2017, INT J BIPOLAR DISORD, V5, P1, DOI 10.1186/s40345-017-0074-8
   Hyman MA, 2009, ALTERN THER HEALTH M, V15, P12
   Inder ML, 2015, BIPOLAR DISORD, V17, P128, DOI 10.1111/bdi.12273
   Jia H, 2018, PSYCHIAT RES, V266, P97, DOI 10.1016/j.psychres.2018.04.059
   Johnson L, 2003, BIPOLAR DISORD, V5, P129, DOI 10.1034/j.1399-5618.2003.00021.x
   Kapczinski NS, 2017, EXPERT REV NEUROTHER, V17, P277, DOI 10.1080/14737175.2017.1240615
   Kaplan KA, 2018, BEHAV RES THER, V111, P106, DOI 10.1016/j.brat.2018.10.009
   Katz DL, 2019, J ALTERN COMPLEM MED, V25, pS19, DOI 10.1089/acm.2018.29058.dlk
   Kilbourne AM, 2007, BIPOLAR DISORD, V9, P443, DOI 10.1111/j.1399-5618.2007.00386.x
   Kilbourne AM, 2012, PSYCHIAT SERV, V63, P1234, DOI 10.1176/appi.ps.201100528
   Kim EY, 2007, J AFFECT DISORDERS, V99, P37, DOI 10.1016/j.jad.2006.08.022
   Koehler K, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071437
   Lalli M, 2021, J PSYCHIATR RES, V144, P285, DOI 10.1016/j.jpsychires.2021.10.012
   Ljungberg T, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17051616
   Lopresti AL, 2015, J ALTERN COMPLEM MED, V21, P733, DOI 10.1089/acm.2015.0125
   Malhotra N, 2016, INDIAN J MED RES, V143, P434, DOI 10.4103/0971-5916.184284
   Miklowitz DJ, 2007, ARCH GEN PSYCHIAT, V64, P419, DOI 10.1001/archpsyc.64.4.419
   Miskowiak KW, 2022, BIPOLAR DISORD, V24, P354, DOI 10.1111/bdi.13193
   Murray G, 2021, J CONSULT CLIN PSYCH, V89, P830, DOI 10.1037/ccp0000684
   Owen R, 2017, CLIN PSYCHOL PSYCHOT, V24, P911, DOI 10.1002/cpp.2055
   Pascual-Sánchez A, 2019, J AFFECT DISORDERS, V255, P105, DOI 10.1016/j.jad.2019.05.032
   Plante DT, 2008, AM J PSYCHIAT, V165, P830, DOI 10.1176/appi.ajp.2008.08010077
   Quello Susan B, 2005, Sci Pract Perspect, V3, P13
   Rippe JM, 2020, AM J LIFESTYLE MED, V14, P4, DOI 10.1177/1559827619878100
   Rosa AR, 2014, J CLIN PSYCHIAT, V75, pE450, DOI 10.4088/JCP.13m08625
   Sit DK, 2018, AM J PSYCHIAT, V175, P131, DOI 10.1176/appi.ajp.2017.16101200
   Sverdlichenko I, 2020, J AFFECT DISORDERS, V266, P252, DOI 10.1016/j.jad.2020.01.111
   Sylvia LG, 2019, J AFFECT DISORDERS, V250, P278, DOI 10.1016/j.jad.2019.03.033
   Todd NJ, 2014, J AFFECT DISORDERS, V169, P21, DOI 10.1016/j.jad.2014.07.027
   Van Rheenen TE, 2020, BIPOLAR DISORD, V22, P13, DOI 10.1111/bdi.12821
   Vancampfort D, 2013, J AFFECT DISORDERS, V145, P285, DOI 10.1016/j.jad.2012.07.020
   Velten Julia, 2014, BMC Psychol, V2, P58, DOI 10.1186/s40359-014-0055-y
NR 62
TC 14
Z9 15
U1 4
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD SEP
PY 2023
VL 152
AR 105257
DI 10.1016/j.neubiorev.2023.105257
EA JUN 2023
PG 13
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA L2ND4
UT WOS:001021668600001
PM 37263531
DA 2025-06-11
ER

PT J
AU Kajikawa, M
   Higashi, Y
AF Kajikawa, Masato
   Higashi, Yukihito
TI Obesity and Endothelial Function
SO BIOMEDICINES
LA English
DT Review
DE obesity; endothelial function; atherosclerosis; cardiovascular events
ID BODY-MASS INDEX; EPICARDIAL ADIPOSE-TISSUE; FLOW-MEDIATED VASODILATION;
   FATTY LIVER-DISEASE; MEDITERRANEAN DIET; BARIATRIC SURGERY;
   NITRIC-OXIDE; INSULIN-RESISTANCE; METABOLIC SYNDROME; RISK-FACTORS
AB Obesity is a major public health problem and is related to increasing rates of cardiovascular morbidity and mortality. Over 1.9 billion adults are overweight or obese worldwide and the prevalence of obesity is increasing. Obesity influences endothelial function through obesity-related complications such as hypertension, dyslipidemia, diabetes, metabolic syndrome, and obstructive sleep apnea syndrome. The excess fat accumulation in obesity causes adipocyte dysfunction and induces oxidative stress, insulin resistance, and inflammation leading to endothelial dysfunction. Several anthropometric indices and imaging modalities that are used to evaluate obesity have demonstrated an association between obesity and endothelial function. In the past few decades, there has been great focus on the mechanisms underlying endothelial dysfunction caused by obesity for the prevention and treatment of cardiovascular events. This review focuses on pathophysiological mechanisms of obesity-induced endothelial dysfunction and therapeutic targets of obesity.
C1 [Kajikawa, Masato; Higashi, Yukihito] Hiroshima Univ Hosp, Med Ctr Translat & Clin Res, Div Regenerat & Med, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan.
   [Higashi, Yukihito] Hiroshima Univ, Res Inst Radiat Biol & Med, Div Radiat Med Sci, Dept Regenerat Med,Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan.
C3 Hiroshima University; Hiroshima University
RP Higashi, Y (corresponding author), Hiroshima Univ Hosp, Med Ctr Translat & Clin Res, Div Regenerat & Med, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan.; Higashi, Y (corresponding author), Hiroshima Univ, Res Inst Radiat Biol & Med, Div Radiat Med Sci, Dept Regenerat Med,Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan.
EM m-kajikawa@hiroshima-u.ac.jp; yhigashi@hiroshima-u.ac.jp
OI Higashi, Yukihito/0000-0001-5813-3672
FU JSPS KAKENHI [18590815, 21590898, JP19K17599]; Takeda Science
   Foundation; Japanese Arteriosclerosis Prevention Fund; Grants-in-Aid for
   Scientific Research [23K24329, 22H03068] Funding Source: KAKEN
FX This work was supported by JSPS KAKENHI (Grant Number 18590815 and
   21590898 to Y.H. and JP19K17599 to M.K.), the Takeda Science Foundation
   (to M.K.), and a Grant in Aid of Japanese Arteriosclerosis Prevention
   Fund (to Y.H.).
CR Afshin A, 2017, NEW ENGL J MED, V377, P13, DOI 10.1056/NEJMoa1614362
   Ahmad E, 2021, DIABETES OBES METAB, V23, P1409, DOI 10.1111/dom.14343
   Ahmad NN, 2021, OBES REV, V22, DOI 10.1111/obr.13326
   Ahrén B, 2017, LANCET DIABETES ENDO, V5, P341, DOI 10.1016/S2213-8587(17)30092-X
   Al-Amrani A, 2019, ARCH MED SCI, V15, P1113, DOI 10.5114/aoms.2018.76684
   Alberti L, 2009, ATHEROSCLEROSIS, V202, P455, DOI 10.1016/j.atherosclerosis.2008.05.015
   Altinova AE, 2022, J CLIN ENDOCR METAB, V107, pE1778, DOI 10.1210/clinem/dgab921
   Alvares TS, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-54
   Arcaro G, 1999, INT J OBESITY, V23, P936, DOI 10.1038/sj.ijo.0801022
   Artemniak-Wojtowicz D, 2020, CENT EUR J IMMUNOL, V45, P461, DOI 10.5114/ceji.2020.103418
   Aslan AN, 2015, ECHOCARDIOGR-J CARD, V32, P1745, DOI 10.1111/echo.12960
   Batsis JA, 2013, AM J CARDIOL, V112, P1592, DOI 10.1016/j.amjcard.2013.07.014
   Becher T, 2021, NAT MED, V27, P58, DOI 10.1038/s41591-020-1126-7
   Bellicha A, 2021, OBES REV, V22, DOI 10.1111/obr.13256
   Bertoni N, 2018, PREV MED, V111, P1, DOI 10.1016/j.ypmed.2018.02.017
   Britton KA, 2011, CIRCULATION, V124, pE837, DOI 10.1161/CIRCULATIONAHA.111.077602
   Cai JJ, 2020, CIRC RES, V126, P679, DOI 10.1161/CIRCRESAHA.119.316337
   CELERMAJER DS, 1992, LANCET, V340, P1111, DOI 10.1016/0140-6736(92)93147-F
   Cesari F, 2018, NUTR METAB CARDIOVAS, V28, P84, DOI 10.1016/j.numecd.2017.09.003
   Chang L, 2020, ARTERIOSCL THROM VAS, V40, P1094, DOI 10.1161/ATVBAHA.120.312464
   Cheong LY, 2021, J MOL CELL BIOL, V13, P466, DOI 10.1093/jmcb/mjab038
   Choi D, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.119.013471
   Chung JH, 2014, BIOCHEM BIOPH RES CO, V451, P179, DOI 10.1016/j.bbrc.2014.07.083
   Ciccone MM, 2012, INT J CARDIOL, V158, P383, DOI 10.1016/j.ijcard.2011.01.065
   Claridy MD, 2021, MAYO CLIN PROC, V96, P2991, DOI 10.1016/j.mayocp.2021.07.021
   Cypess AM, 2022, NEW ENGL J MED, V386, P768, DOI 10.1056/NEJMra2032804
   Dai GR, 2019, MEDICINE, V98, DOI [10.1097/MD.0000000000014324, 10.1097/md.0000000000014324]
   Dantas WS, 2018, J AM COLL CARDIOL, V72, P2278, DOI 10.1016/j.jacc.2018.07.094
   Davies M, 2021, LANCET, V397, P971, DOI 10.1016/S0140-6736(21)00213-0
   Davis CR, 2017, AM J CLIN NUTR, V105, P1305, DOI 10.3945/ajcn.116.146803
   De Ciuceis C, 2018, HIGH BLOOD PRESS CAR, V25, P369, DOI 10.1007/s40292-018-0279-7
   De Filippis E, 2006, J CLIN ENDOCR METAB, V91, P4903, DOI 10.1210/jc.2006-1142
   de Lorgeril M, 1999, CIRCULATION, V99, P779, DOI 10.1161/01.CIR.99.6.779
   Després JP, 2012, CIRCULATION, V126, P1301, DOI 10.1161/CIRCULATIONAHA.111.067264
   Di Francescomarino S, 2009, SPORTS MED, V39, P797, DOI 10.2165/11317750-000000000-00000
   Dias IBF, 2013, CLIN ENDOCRINOL, V79, P667, DOI 10.1111/cen.12195
   El Assar M, 2016, J PHYSIOL-LONDON, V594, P3045, DOI 10.1113/JP271836
   Erdogdu Ö, 2010, MOL CELL ENDOCRINOL, V325, P26, DOI 10.1016/j.mce.2010.04.022
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   Estruch R, 2018, NEW ENGL J MED, V378, DOI [10.1056/NEJMoa1800389, 10.1056/NEJMoa1200303, 10.1056/nejmoa1800389]
   Field AE, 2001, ARCH INTERN MED, V161, P1581, DOI 10.1001/archinte.161.13.1581
   Finlin BS, 2020, J CLIN INVEST, V130, P2319, DOI 10.1172/JCI134892
   Franks PW, 2010, NEW ENGL J MED, V362, P485, DOI 10.1056/NEJMoa0904130
   Fraum TJ, 2019, CELL METAB, V30, P212, DOI 10.1016/j.cmet.2019.05.019
   Fuentes F, 2001, ANN INTERN MED, V134, P1115, DOI 10.7326/0003-4819-134-12-200106190-00011
   Fukumoto K, 2021, HYPERTENS RES, V44, P63, DOI 10.1038/s41440-020-0516-z
   Galougahi KK, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.115.002824
   Gambardella J, 2020, BIOMEDICINES, V8, DOI 10.3390/biomedicines8080277
   Gaspar RC, 2021, AM J PHYSIOL-ENDOC M, V320, pE488, DOI 10.1152/ajpendo.00310.2020
   Gielen S, 2001, CIRCULATION, V103, pE1
   Gluszewska A, 2019, J PHYSIOL PHARMACOL, V70, P909, DOI 10.26402/jpp.2019.6.09
   Golbidi S, 2017, CURR DIABETES REP, V17, DOI 10.1007/s11892-017-0951-7
   Gottlieb DJ, 2020, JAMA-J AM MED ASSOC, V323, P1389, DOI 10.1001/jama.2020.3514
   Gregg EW, 2016, LANCET DIABETES ENDO, V4, P913, DOI 10.1016/S2213-8587(16)30162-0
   Hashimoto H, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-020-80012-x
   Heinonen S, 2020, OBES REV, V21, DOI 10.1111/obr.12958
   Higashi Y, 2003, J AM COLL CARDIOL, V42, P256, DOI 10.1016/S0735-1097(03)00630-2
   Higashi Y, 2009, CIRC J, V73, P411, DOI 10.1253/circj.CJ-08-1102
   Hopkins ND, 2013, DIABETES OBES METAB, V15, P770, DOI 10.1111/dom.12089
   Horimatsu T, 2018, CARDIOVASC DRUG THER, V32, P503, DOI 10.1007/s10557-018-6821-y
   Hu Y, 2018, NEW ENGL J MED, V379, P623, DOI 10.1056/NEJMoa1803626
   HUBERT HB, 1983, CIRCULATION, V67, P968, DOI 10.1161/01.CIR.67.5.968
   Hunag JH, 2017, PEERJ, V5, DOI 10.7717/peerj.3669
   Husain M, 2019, NEW ENGL J MED, V381, P841, DOI 10.1056/NEJMoa1901118
   Ishibashi Y, 2010, BIOCHEM BIOPH RES CO, V391, P1405, DOI 10.1016/j.bbrc.2009.12.075
   Jelic S, 2008, CIRCULATION, V117, P2270, DOI 10.1161/CIRCULATIONAHA.107.741512
   Jensen MD, 2014, CIRCULATION, V129, pS102, DOI 10.1161/01.cir.0000437739.71477.ee
   Johnson FK, 2015, OBESITY, V23, P383, DOI 10.1002/oby.20969
   Joris PJ, 2015, ATHEROSCLEROSIS, V239, P21, DOI 10.1016/j.atherosclerosis.2014.12.056
   Joshi S, 2019, JAMA INTERN MED, V179, P1163, DOI 10.1001/jamainternmed.2019.2633
   Jung DY, 2022, LIFE SCI, V298, DOI 10.1016/j.lfs.2022.120488
   Juonala M, 2011, NEW ENGL J MED, V365, P1876, DOI 10.1056/NEJMoa1010112
   Kajikawa M, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-97325-0
   Kajikawa M, 2021, INT J CARDIOL, V324, P186, DOI 10.1016/j.ijcard.2020.09.029
   Kajikawa M, 2019, CURR OPIN LIPIDOL, V30, P364, DOI 10.1097/MOL.0000000000000630
   Kajikawa M, 2016, INT J CARDIOL, V225, P91, DOI 10.1016/j.ijcard.2016.09.123
   Kajikawa M, 2016, HYPERTENSION, V67, P1045, DOI 10.1161/HYPERTENSIONAHA.115.06839
   Khan SS, 2018, JAMA CARDIOL, V3, P280, DOI 10.1001/jamacardio.2018.0022
   Kim H, 2020, AM J HEALTH PROMOT, V34, P96, DOI 10.1177/0890117119872863
   Kocaman SA, 2013, BLOOD PRESS MONIT, V18, P85, DOI 10.1097/MBP.0b013e32835ebbb5
   Kocyigit I, 2014, J ATHEROSCLER THROMB, V21, P1066, DOI 10.5551/jat.23259
   Koenen M, 2021, CIRC RES, V128, P951, DOI 10.1161/CIRCRESAHA.121.318093
   Kozlitina J, 2014, NAT GENET, V46, P352, DOI 10.1038/ng.2901
   Krist AH, 2020, JAMA-J AM MED ASSOC, V324, P2069, DOI 10.1001/jama.2020.21749
   Labarca G, 2020, SLEEP BREATH, V24, P751, DOI 10.1007/s11325-019-01967-4
   Lau WB, 2017, CIRC J, V81, P920, DOI 10.1253/circj.CJ-17-0458
   Lauridsen BK, 2018, EUR HEART J, V39, P385, DOI 10.1093/eurheartj/ehx662
   Lee DY, 2018, OBESITY, V26, P1096, DOI 10.1002/oby.22193
   Li H, 2020, DIABET METAB SYND OB, V13, P2551, DOI 10.2147/DMSO.S248112
   Li JM, 2020, EUR REV MED PHARMACO, V24, P905, DOI 10.26355/eurrev_202001_20075
   Lim S, 2014, ARTERIOSCL THROM VAS, V34, P1820, DOI 10.1161/ATVBAHA.114.303035
   Lingvay I, 2019, LANCET DIABETES ENDO, V7, P834, DOI 10.1016/S2213-8587(19)30311-0
   Lobelo F, 2018, CIRCULATION, V137, pE495, DOI 10.1161/CIR.0000000000000559
   Lupoli R, 2016, INT J OBESITY, V40, P395, DOI 10.1038/ijo.2015.187
   LUSCHER TF, 1986, HYPERTENSION, V8, P344, DOI 10.1161/01.HYP.8.4.344
   Ma CH, 2017, BMJ-BRIT MED J, V359, DOI 10.1136/bmj.j4849
   Mahfouz RA, 2015, ECHOCARDIOGR-J CARD, V32, P28, DOI 10.1111/echo.12595
   Manka D, 2014, ARTERIOSCL THROM VAS, V34, P1723, DOI 10.1161/ATVBAHA.114.303983
   Margaritis M, 2013, CIRCULATION, V127, P2209, DOI 10.1161/CIRCULATIONAHA.112.001133
   Marso SP, 2016, NEW ENGL J MED, V375, P1834, DOI 10.1056/NEJMoa1607141
   Martin M, 2010, SURG OBES RELAT DIS, V6, P8, DOI 10.1016/j.soard.2009.07.003
   Maruhashi T, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10081306
   Masi S, 2018, ARTERIOSCL THROM VAS, V38, P2474, DOI 10.1161/ATVBAHA.118.311074
   Mazurek T, 2003, CIRCULATION, V108, P2460, DOI 10.1161/01.CIR.0000099542.57313.C5
   Mazzotta C, 2021, ARTERIOSCL THROM VAS, V41, P1239, DOI 10.1161/ATVBAHA.120.315865
   Morimoto H, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.116.004385
   Mousavi SM, 2021, INT J VITAM NUTR RES, V91, P164, DOI 10.1024/0300-9831/a000523
   Müller TD, 2022, NAT REV DRUG DISCOV, V21, P201, DOI 10.1038/s41573-021-00337-8
   Nomoto H, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0135854
   Nordmann AJ, 2011, AM J MED, V124, P841, DOI 10.1016/j.amjmed.2011.04.024
   O'Brien PE, 2019, OBES SURG, V29, P3, DOI 10.1007/s11695-018-3525-0
   O'Mara AE, 2020, J CLIN INVEST, V130, P2209, DOI 10.1172/JCI131126
   Ouchi N, 2003, HYPERTENSION, V42, P231, DOI 10.1161/01.HYP.0000083488.67550.B8
   Ouchi N, 2000, CIRCULATION, V102, P1296, DOI 10.1161/01.CIR.102.11.1296
   Pacifico L, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.574216
   Papadaki A, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113342
   Pareyn A, 2015, PEDIATR DIABETES, V16, P98, DOI 10.1111/pedi.12139
   Parikh NI, 2009, OBESITY, V17, P2054, DOI 10.1038/oby.2009.60
   Payne GA, 2010, ARTERIOSCL THROM VAS, V30, P1711, DOI 10.1161/ATVBAHA.110.210070
   Peña AS, 2006, J CLIN ENDOCR METAB, V91, P4467, DOI 10.1210/jc.2006-0863
   Pietiläinen KH, 2008, OBESITY, V16, P409, DOI 10.1038/oby.2007.72
   Pratley RE, 2018, LANCET DIABETES ENDO, V6, P275, DOI 10.1016/S2213-8587(18)30024-X
   Pugh CJA, 2014, AM J PHYSIOL-HEART C, V307, pH1298, DOI 10.1152/ajpheart.00306.2014
   Qi JC, 2019, SLEEP BREATH, V23, P5, DOI 10.1007/s11325-018-1660-4
   Raiko J, 2020, ARTERIOSCL THROM VAS, V40, P1289, DOI 10.1161/ATVBAHA.119.313806
   Rajapakse NW, 2016, HYPERTENSION, V67, P813, DOI 10.1161/HYPERTENSIONAHA.116.06778
   Rallidis LS, 2009, AM J CLIN NUTR, V90, P263, DOI 10.3945/ajcn.2008.27290
   Rehman K, 2021, EUR J PHARMACOL, V909, DOI 10.1016/j.ejphar.2021.174410
   Rodrigues-Krause J, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010015
   Roh HC, 2018, CELL METAB, V27, P1121, DOI 10.1016/j.cmet.2018.03.005
   Romero-Corral A, 2008, INT J OBESITY, V32, P959, DOI 10.1038/ijo.2008.11
   Romero-Corral A, 2010, J AM COLL CARDIOL, V56, P662, DOI 10.1016/j.jacc.2010.03.063
   Ros E, 2004, CIRCULATION, V109, P1609, DOI 10.1161/01.CIR.0000124477.91474.FF
   Ross R, 2004, OBES RES, V12, P789, DOI 10.1038/oby.2004.95
   Ross R, 2000, ANN INTERN MED, V133, P92, DOI 10.7326/0003-4819-133-2-200007180-00008
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Roth CL, 2021, METABOLITES, V11, DOI 10.3390/metabo11050319
   Rubino D, 2021, JAMA-J AM MED ASSOC, V325, P1414, DOI 10.1001/jama.2021.3224
   Sawyer BJ, 2016, J APPL PHYSIOL, V121, P279, DOI 10.1152/japplphysiol.00024.2016
   Schulman SP, 2006, JAMA-J AM MED ASSOC, V295, P58, DOI 10.1001/jama.295.1.58
   Shaman AM, 2022, CIRCULATION, V145, P575, DOI 10.1161/CIRCULATIONAHA.121.055459
   Shannon OM, 2020, J NUTR, V150, P1151, DOI 10.1093/jn/nxaa002
   Sherwani SI, 2013, SLEEP, V36, P1849, DOI 10.5665/sleep.3214
   Shi QY, 2022, LANCET, V399, P259, DOI 10.1016/S0140-6736(21)01640-8
   Shiraseb F, 2022, ADV NUTR, V13, P1226, DOI 10.1093/advances/nmab155
   Singh AM, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-16340-3
   Sjöström L, 2012, JAMA-J AM MED ASSOC, V307, P56, DOI 10.1001/jama.2011.1914
   Skinner AC, 2015, NEW ENGL J MED, V373, P1307, DOI 10.1056/NEJMoa1502821
   Smith U, 2015, J CLIN INVEST, V125, P1790, DOI 10.1172/JCI81507
   Stevens J, 1998, NEW ENGL J MED, V338, P1, DOI 10.1056/NEJM199801013380101
   Sturm W, 2009, OBESITY, V17, P1783, DOI 10.1038/oby.2009.81
   Su X, 2020, MOL BIOL REP, V47, P7991, DOI 10.1007/s11033-020-05732-9
   Szlas A, 2022, NUTRIENTS, V14, DOI 10.3390/nu14050961
   Takatsu M, 2013, HYPERTENSION, V62, P957, DOI 10.1161/HYPERTENSIONAHA.113.02093
   Tanaka A, 2018, INT J CARDIOL, V272, P308, DOI 10.1016/j.ijcard.2018.06.017
   Tjonna AE, 2008, CIRCULATION, V118, P346, DOI 10.1161/CIRCULATIONAHA.108.772822
   Tokushige A, 2017, CIRC J, V81, P1911, DOI 10.1253/circj.CJ-17-0211
   Torigoe M, 2007, CLIN ENDOCRINOL, V67, P276, DOI 10.1111/j.1365-2265.2007.02876.x
   Torres-Peña JD, 2018, ATHEROSCLEROSIS, V269, P50, DOI 10.1016/j.atherosclerosis.2017.12.012
   Tsou MT, 2021, DIAGNOSTICS, V11, DOI 10.3390/diagnostics11010040
   VALLANCE P, 1989, LANCET, V2, P997
   van der Heijden DJ, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.117.006082
   VANE JR, 1990, NEW ENGL J MED, V323, P27
   Vest AR, 2012, HEART, V98, P1763, DOI 10.1136/heartjnl-2012-301778
   Villela Nivaldo Ribeiro, 2006, Clinics, V61, P53, DOI 10.1590/S1807-59322006000100010
   Virtanen KA, 2009, NEW ENGL J MED, V360, P1518, DOI 10.1056/NEJMoa0808949
   Wadden TA, 2021, JAMA-J AM MED ASSOC, V325, P1403, DOI 10.1001/jama.2021.1831
   Wang JY, 2015, J AM HEART ASSOC, V4, DOI 10.1161/JAHA.115.002454
   Wang RW, 2020, J SPORT HEALTH SCI, V9, P211, DOI 10.1016/j.jshs.2019.09.008
   Wang XW, 2022, HEART, V108, P375, DOI 10.1136/heartjnl-2021-318972
   Watts K, 2004, J AM COLL CARDIOL, V43, P1823, DOI 10.1016/j.jacc.2004.01.032
   WHO Consultation, 2000, WHO TECH REP SER, V894, P1
   Wilding JPH, 2021, NEW ENGL J MED, V384, P989, DOI 10.1056/NEJMoa2032183
   Williams MJA, 2017, INT J OBESITY, V41, P1355, DOI 10.1038/ijo.2017.108
   Wing R, 2013, NEW ENGL J MED, V369, P145, DOI 10.1056/NEJMoa1212914
   Yang XH, 2022, FOOD FUNCT, V13, P1232, DOI [10.1039/d1fo02608a, 10.1039/D1FO02608A]
   Yanovski SZ, 2021, JAMA-J AM MED ASSOC, V326, P129, DOI 10.1001/jama.2021.9486
   Yilmaz MI, 2008, NEPHROL DIAL TRANSPL, V23, P1621, DOI 10.1093/ndt/gfm828
   Yki-Järvinen H, 2014, LANCET DIABETES ENDO, V2, P901, DOI 10.1016/S2213-8587(14)70032-4
   Yoneshiro T, 2011, OBESITY, V19, P1755, DOI 10.1038/oby.2011.125
   Yubero-Serrano EM, 2020, PLOS MED, V17, DOI 10.1371/journal.pmed.1003282
   Zhang FJ, 2018, SLEEP MED, V52, P45, DOI 10.1016/j.sleep.2018.07.023
   Zhang H, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-18086-3
   Zhou JY, 2019, EUR J PHARMACOL, V861, DOI 10.1016/j.ejphar.2019.172594
   Zhou SL, 2020, EUR REV MED PHARMACO, V24, P11707, DOI 10.26355/eurrev_202011_23816
   Zhu L, 2021, J SPORT MED PHYS FIT, V61, P743, DOI 10.23736/S0022-4707.20.11329-X
NR 186
TC 44
Z9 44
U1 0
U2 33
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD JUL
PY 2022
VL 10
IS 7
AR 1745
DI 10.3390/biomedicines10071745
PG 19
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA 3G6UM
UT WOS:000831487100001
PM 35885049
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ng, DS
AF Ng, Dominic S.
TI Diabetic Dyslipidemia: From Evolving Pathophysiological Insight to
   Emerging Therapeutic Targets
SO CANADIAN JOURNAL OF DIABETES
LA English
DT Review
DE cardiovascular diseases; cholesterol efflux; diabetes; dyslipidemia; ER
   stress; HDL; insulin resistance; triglycerides
ID HIGH-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; TANGIER-DISEASE;
   LECITHIN/CHOLESTEROL ACYLTRANSFERASE; METABOLIC SYNDROME; APOLIPOPROTEIN
   AI; CHOLESTEROL; ATHEROSCLEROSIS; TRIGLYCERIDE; INHIBITION
AB Diabetic dyslipidemia is characterized by hepatic very low density lipoprotein (VLDL) and intestinal chylomicron overproduction, reduced high density lipoprotein cholesterol (HDL-C) level, increased propensity of small dense LDL (sdLDL) and increased postprandial lipemia. This dyslipidemic profile is also strongly linked to other features of the metabolic syndrome. Diabetic dyslipidemia is a well-recognized risk factor for atherosclerotic cardiovascular diseases. Currently, statins remain the first line therapy primarily through reducing the atherogenic LDL. Clinical trials on other lipid modifying agents were met with variable success in selective patient populations. Emerging new insights into the pathophysiology of lipid metabolism, in general, and diabetic dyslipidemia, in particular, have opened up potentially novel therapeutic strategies to further reduce the risk associated with diabetic dyslipidemia and insulin resistant state. (C) 2013 Canadian Diabetes Association
C1 Univ Toronto, St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Toronto, ON M5B 1W8, Canada.
C3 University of Toronto; Li Ka Shing Knowledge Institute; Saint Michaels
   Hospital Toronto
RP Ng, DS (corresponding author), Univ Toronto, St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Shuter Wing Room 3-041,30 Bond St, Toronto, ON M5B 1W8, Canada.
EM ngd@smh.ca
FU Canadian Institutes for Health Research (CIHR) [MOP275369]; CIHR
   China-Canada Joint Health Research Initiative grant; Heart and Stroke
   Foundation of Ontario [NA 6331]
FX This work was supported in part by an operating grant from the Canadian
   Institutes for Health Research (CIHR; MOP275369), a CIHR China-Canada
   Joint Health Research Initiative grant and a Grant-in-aid (NA 6331) by
   the Heart and Stroke Foundation of Ontario.
CR Adiels M, 2008, ARTERIOSCL THROM VAS, V28, P1225, DOI 10.1161/ATVBAHA.107.160192
   Aiello RJ, 2002, ARTERIOSCL THROM VAS, V22, P630, DOI 10.1161/01.ATV.0000014804.35824.DA
   Alexander CM, 2003, DIABETES, V52, P1210, DOI 10.2337/diabetes.52.5.1210
   Arca M, 2012, CURR VASC PHARMACOL, V10, P684, DOI 10.2174/157016112803520864
   Bardini Gianluca, 2012, Rev Diabet Stud, V9, P82, DOI 10.1900/RDS.2012.9.82
   Bi X, 2013, ARTERIOSCLER THROMB
   Botham KM, 2007, BIOCHEM SOC T, V35, P454, DOI 10.1042/BST0350454
   Brooks-Wilson A, 1999, NAT GENET, V22, P336, DOI 10.1038/11905
   Brunham LR, 2010, CURR DIABETES REP, V10, P55, DOI 10.1007/s11892-009-0090-x
   Cannon CP, 2009, AM HEART J, V158, P513, DOI 10.1016/j.ahj.2009.07.028
   de Vries FM, 2012, DRUGS, V72, P2365, DOI 10.2165/11638240-000000000-00000
   Dhote V, 2011, CLIN EXP PHARMACOL P, V38, P338, DOI 10.1111/j.1440-1681.2011.05513.x
   Duca L, 2013, CURR DIABETES REP, V13, P350, DOI 10.1007/s11892-013-0380-1
   Duvillard L, 2000, EUR J CLIN INVEST, V30, P685, DOI 10.1046/j.1365-2362.2000.00702.x
   Fisher EA, 2012, BBA-MOL CELL BIOL L, V1821, P778, DOI 10.1016/j.bbalip.2012.02.001
   Forst T, 2012, EXP DIABETES RES, DOI 10.1155/2012/635472
   Ginsberg HN, 2010, NEW ENGL J MED, V362, P1563, DOI 10.1056/NEJMoa1001282
   Goldberg IJ, 2011, ARTERIOSCL THROM VAS, V31, P1716, DOI 10.1161/ATVBAHA.111.226100
   Hager L, 2012, J BIOL CHEM, V287, P20755, DOI 10.1074/jbc.M112.340919
   Haynes R, 2013, EUR HEART J, V34, P1279, DOI 10.1093/eurheartj/eht055
   Hein GJ, 2013, DIABETES, V62, P373, DOI 10.2337/db12-0202
   Hewing B, 2013, ATHEROSCLEROSIS, V227, P125, DOI 10.1016/j.atherosclerosis.2012.12.026
   Kappelle PJWH, 2012, EUR J CLIN INVEST, V42, P487, DOI 10.1111/j.1365-2362.2011.02604.x
   Keech A, 2006, LANCET, V367, P1142, DOI 10.1016/S0140-6736(06)68501-2
   Keech A, 2005, LANCET, V366, P1849, DOI 10.1016/S0140-6736(05)67667-2
   Keech A, 2006, LANCET, V368, P1415, DOI 10.1016/S0140-6736(06)69594-9
   Kei A, 2013, EUR J CLIN INVEST, V43, P698, DOI 10.1111/eci.12095
   KISSEBAH AH, 1982, DIABETES, V31, P217, DOI 10.2337/diabetes.31.3.217
   Koseki M, 2009, J ATHEROSCLER THROMB, V16, P292, DOI 10.5551/jat.E599
   Kostapanos MS, 2013, CURR PHARM DESIGN, V19, P3150
   Kruit JK, 2012, DIABETES, V61, P659, DOI 10.2337/db11-1341
   Li LX, 2011, J BIOL CHEM, V286, P17809, DOI 10.1074/jbc.M110.180893
   Marcil M, 1999, LANCET, V354, P1341, DOI 10.1016/S0140-6736(99)07026-9
   Matikainen N, 2012, CURR CARDIOL REP, V14, P721, DOI 10.1007/s11886-012-0309-3
   McNeill E, 2010, CURR OPIN INVEST DR, V11, P357
   Takamitsu NA, 2008, CLIN CHIM ACTA, V390, P38, DOI 10.1016/j.cca.2007.12.012
   Ng DS, 2012, BBA-MOL CELL BIOL L, V1821, P654, DOI 10.1016/j.bbalip.2011.12.012
   Ng DS, 2004, J BIOL CHEM, V279, P7636, DOI 10.1074/jbc.M309439200
   NG DS, 1994, J CLIN INVEST, V93, P223, DOI 10.1172/JCI116949
   Nicholls SJ, 2012, J AM COLL CARDIOL, V59, P2065, DOI 10.1016/j.jacc.2012.02.021
   Nissen SE, 2003, JAMA-J AM MED ASSOC, V290, P2292, DOI 10.1001/jama.290.17.2292
   Nonomura K, 2011, ATHEROSCLEROSIS, V216, P334, DOI 10.1016/j.atherosclerosis.2011.02.021
   Pajvani U. B., 2013, NAT MED
   Pan XY, 2012, BBA-MOL CELL BIOL L, V1821, P727, DOI 10.1016/j.bbalip.2011.09.013
   Phan BAP, 2013, AM J CARDIOL, V111, P352, DOI 10.1016/j.amjcard.2012.09.034
   Rayner KJ, 2010, SCIENCE, V328, P1570, DOI 10.1126/science.1189862
   RUBIN EM, 1991, NATURE, V353, P265, DOI 10.1038/353265a0
   Rubins HB, 1999, NEW ENGL J MED, V341, P410, DOI 10.1056/NEJM199908053410604
   Rust S, 1999, NAT GENET, V22, P352, DOI 10.1038/11921
   Schwartz EA, 2010, ATHEROSCLEROSIS, V212, P217, DOI 10.1016/j.atherosclerosis.2010.05.028
   Singaraja RR, 2006, CIRCULATION, V114, P1301, DOI 10.1161/CIRCULATIONAHA.106.621433
   Steiner G, 2000, DIABETES CARE, V23, pB49
   Tanaka S, 2013, ARTERIOSCL THROM VAS, V33, P1098, DOI 10.1161/ATVBAHA.113.301297
   Tardif JC, 2007, JAMA-J AM MED ASSOC, V297, P1675, DOI 10.1001/jama.297.15.jpc70004
   Toth PP, 2013, CURR VASC PHARMACOL
   Umemoto T, 2013, CIRC RES, V112, P1345, DOI 10.1161/CIRCRESAHA.111.300581
   Van Eck M, 2006, ARTERIOSCL THROM VAS, V26, P929, DOI 10.1161/01.ATV.0000208364.22732.16
   Visser ME, 2012, EUR HEART J, V33, P1451, DOI 10.1093/eurheartj/ehs084
   Wadwa RP, 2005, DIABETES CARE, V28, P1051, DOI 10.2337/diacare.28.5.1051
   Weinstein MM, 2010, ARTERIOSCL THROM VAS, V30, P20, DOI 10.1161/ATVBAHA.109.196329
   Westerterp M., 2013, Circulation Research
   Xiao CT, 2012, ARTERIOSCL THROM VAS, V32, P1513, DOI 10.1161/ATVBAHA.112.246207
   Xiao CT, 2012, BBA-MOL CELL BIOL L, V1821, P736, DOI 10.1016/j.bbalip.2011.09.019
   Yecies JL, 2011, CELL METAB, V14, P21, DOI 10.1016/j.cmet.2011.06.002
NR 64
TC 29
Z9 30
U1 0
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1499-2671
J9 CAN J DIABETES
JI Can. J. Diabetes
PD OCT
PY 2013
VL 37
IS 5
BP 319
EP 326
DI 10.1016/j.jcjd.2013.07.062
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AL8WC
UT WOS:000339419400008
PM 24500559
DA 2025-06-11
ER

PT J
AU Aishwarya, J
   Bobby, Z
   Nair, PP
   Sunitha, VC
   Menon, V
   Thalapalliyil, K
AF Aishwarya, J.
   Bobby, Zachariah
   Nair, Pradeep P.
   Sunitha, V. C.
   Menon, Vikas
   Thalapalliyil, Kamila
TI Increased vascular risk factors, atherosclerosis, and psychological
   distress among Indian adults with refractory epilepsy in comparison to
   well-controlled epilepsy
SO EPILEPSY & BEHAVIOR
LA English
DT Article
DE Refractory epilepsy; Metabolic syndrome; Atherosclerosis; Psychological
   distress; Vascular risk factors
ID INTIMA-MEDIA THICKNESS; IDENTIFYING INSULIN-RESISTANCE; SUDDEN
   UNEXPECTED DEATH; LIPID TETRAD INDEX; ANTIEPILEPTIC DRUGS; METABOLIC
   SYNDROME; CARDIOVASCULAR RISK; YOUNG-ADULTS; ATHEROGENIC INDEX; VALPROIC
   ACID
AB Objective: Comparison of cardiovascular risk factors, atherosclerosis, and psychological distress among adults with refractory versus well-controlled epilepsy.Methods: The cross-sectional study consisted of two groups of 40 people each: Group I - People with well-controlled epilepsy, Group II - People with refractory epilepsy. Age-and gender-matched people of 20-50 years were recruited. People who were diabetic, smokers, hypertensive, alcoholic, pregnant, with infections, and lactating women were excluded from the study. Biochemical parameters, fasting glucose, lipid profile, fasting insulin, leptin, adiponectin, Lp[a], hsCRP, TyG INDEX, HOMA1-%S, HOMA1-IR, HOMA1-%B, QUICKI, FIRI, AIP, AC, CLTI, MLTI, CRI-I, CRI-II, and CIMT were estimated. Stress levels [PSS-10, GAD-7 & PHQ-9] were assessed based on the scoring system from the questionnaires.Results: The existence of metabolic syndrome, levels of triglycerides, TyG index, MDA, OSI, CIMT, AIP, and stress scores [PSS-10, GAD-7 & PHQ-9] were significantly higher in the refractory-epilepsy group in com-parison to the well-controlled group. There were associations between LDL-C and CIMT as well as between GAD-7 and CIMT among all the study subjects. There were no significant differences in the levels of glucose homeostasis parameters, hsCRP, leptin, adiponectin, and Lp[a] between the two groups. Based on the ROC analysis, MDA [AUC = 0.853] and GAD-7 [AUC = 0.900] are useful in the differential diagnosis of the study groups.Conclusion: People with refractory epilepsy had increased levels of vascular risk factors, atherosclerosis, and stress levels compared to people with well-controlled epilepsy. Suitable disease management and therapeutic approaches to address cardiovascular and psychological distress could be planned out among people with refractory epilepsy to improve their quality of life. & COPY; 2023 Elsevier Inc. All rights reserved.
C1 [Aishwarya, J.; Bobby, Zachariah; Thalapalliyil, Kamila] Jawaharlal Inst Postgrad Med Educ & Res JIPMER, Dept Biochem, Pondicherry, India.
   [Nair, Pradeep P.] Jawaharlal Inst Postgrad Med Educ & Res JIPMER, Dept Neurol, Pondicherry, India.
   [Sunitha, V. C.] Jawaharlal Inst Postgrad Med Educ & Res JIPMER, Dept Radiodiag, Pondicherry, India.
   [Menon, Vikas] Jawaharlal Inst Postgrad Med Educ & Res JIPMER, Dept Psychiat, Pondicherry, India.
   [Bobby, Zachariah] JIPMER, Pondicherry 605006, India.
C3 Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research
RP Bobby, Z (corresponding author), JIPMER, Pondicherry 605006, India.
EM zacbobby@yahoo.com
RI Nair, Pradeep/K-4401-2015; Menon, Vikas/F-3100-2012; J,
   Aishwarya/HIZ-5699-2022; Zachariah, Bobby/IUQ-0806-2023
OI Vellathussery Chakkalakkoombil, Sunitha/0000-0001-7161-0277; Menon,
   Vikas/0000-0001-8035-4658; J, Aishwarya/0000-0002-0282-6434
CR Altin C, 2016, ANGIOLOGY, V67, P961, DOI 10.1177/0003319716643669
   [Anonymous], 2010, Br J Cardiol
   Bansal Sanjiv Kumar, 2016, J Lab Physicians, V8, P77, DOI 10.4103/0974-2727.180786
   Bazhanova ED, 2021, BRAIN SCI, V11, DOI 10.3390/brainsci11050663
   Belalcazar S, 2020, ARCH MED, V20, P11, DOI 10.30554/archmed.20.1.3534.2020
   Benzie IFF, 1996, ANAL BIOCHEM, V239, P70, DOI 10.1006/abio.1996.0292
   Borowicz-Reutt KK, 2020, PHARMACOL REP, V72, P1218, DOI 10.1007/s43440-020-00143-w
   Castro-Gago M, 2006, J CHILD NEUROL, V21, P48, DOI 10.1177/08830738060210011601
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Cramer JA, 2010, EXPERT REV NEUROTHER, V10, P885, DOI [10.1586/ern.10.71, 10.1586/ERN.10.71]
   Das S, 2016, ATHEROSCLEROSIS, V252, pE125, DOI 10.1016/j.atherosclerosis.2016.07.653
   DocsPercieved Stress Scale.pdf, US
   DUNCAN MH, 1995, LANCET, V346, P120, DOI 10.1016/S0140-6736(95)92143-5
   EIRIS JM, 1995, NEUROLOGY, V45, P1155, DOI 10.1212/WNL.45.6.1155
   El-Farahaty RM, 2015, J CHILD NEUROL, V30, P451, DOI 10.1177/0883073814551388
   Endermann M, 2013, EPILEPSY BEHAV, V26, P188, DOI 10.1016/j.yebeh.2012.12.002
   Erdemir A, 2009, BRAIN DEV-JPN, V31, P713, DOI 10.1016/j.braindev.2008.11.001
   Ethemoglu O, 2018, SEIZURE-EUR J EPILEP, V60, P105, DOI 10.1016/j.seizure.2018.06.009
   Galtrey Clare M, 2016, Pract Neurol, V16, P270, DOI 10.1136/practneurol-2015-001337
   Geloneze B, 2009, ARQ BRAS ENDOCRINOL, V53, P281, DOI 10.1590/S0004-27302009000200020
   Geronzi U, 2018, EXPERT REV NEUROTHER, V18, P427, DOI 10.1080/14737175.2018.1465410
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Hamed SA, 2014, EPILEPSY BEHAV, V41, P290, DOI 10.1016/j.yebeh.2014.07.003
   Hansa Gupta, 2003, Asian Cardiovasc Thorac Ann, V11, P217
   Harden C, 2017, NEUROLOGY, V88, P1674, DOI 10.1212/WNL.0000000000003685
   Hesdorffer DC, 2011, EPILEPSIA, V52, P1150, DOI 10.1111/j.1528-1167.2010.02952.x
   HOWARD G, 1993, STROKE, V24, P1297, DOI 10.1161/01.STR.24.9.1297
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Janszky I, 2009, BRAIN, V132, P2798, DOI 10.1093/brain/awp216
   Karatoprak E, 2020, BRAIN DEV-JPN, V42, P165, DOI 10.1016/j.braindev.2019.11.004
   Kasliwal Ravi R, 2014, Indian J Endocrinol Metab, V18, P13, DOI 10.4103/2230-8210.126522
   Kassaw AB, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0279580
   Katsiki N, 2014, SEIZURE-EUR J EPILEP, V23, P677, DOI 10.1016/j.seizure.2014.05.011
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Kwan P, 2010, EPILEPSIA, V51, P1069, DOI 10.1111/j.1528-1167.2009.02397.x
   Lai QL, 2017, J CLIN NEUROL, V13, P371, DOI 10.3988/jcn.2017.13.4.371
   Lee EB, 2011, J NEUROSCI, V31, P14361, DOI 10.1523/JNEUROSCI.3171-11.2011
   Lehtimäki KA, 2011, EPILEPSY RES, V95, P184, DOI 10.1016/j.eplepsyres.2011.03.004
   Liu HY, 2018, ONCOTARGET, V9, P2887, DOI [10.18632/oncotarget.20812, 10.18632/oncotarget.23208]
   LoPinto-Khoury C, 2010, CURR TREAT OPTION NE, V12, P300, DOI 10.1007/s11940-010-0080-y
   Pedre LL, 2018, BEHAV SCI, V8, DOI 10.3390/bs8060059
   Mac TL, 2007, LANCET NEUROL, V6, P533, DOI 10.1016/S1474-4422(07)70127-8
   Massey CA, 2014, NAT REV NEUROL, V10, P271, DOI 10.1038/nrneurol.2014.64
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mckee HR, 2017, SEIZURE-EUR J EPILEP, V44, P21, DOI 10.1016/j.seizure.2016.12.009
   Nair Deepu, 2009, Prev Cardiol, V12, P19
   Nair SS, 2016, SEIZURE-EUR J EPILEP, V37, P61, DOI 10.1016/j.seizure.2016.03.002
   Naziroglu M, 2013, CELL MOL NEUROBIOL, V33, P589, DOI 10.1007/s10571-013-9936-5
   Nisha Y, 2018, SEIZURE-EUR J EPILEP, V60, P57, DOI 10.1016/j.seizure.2018.06.003
   Olamoyegun MA, 2016, ANN AFR MED, V15, P194, DOI 10.4103/1596-3519.194280
   Onut Roxana, 2012, Maedica (Bucur), V7, P153
   Oren A, 2003, ARCH INTERN MED, V163, P1787, DOI 10.1001/archinte.163.15.1787
   Parfenova H, 2010, AM J PHYSIOL-HEART C, V298, pH1687, DOI 10.1152/ajpheart.00032.2010
   patient.info, PHQ 9 DEPR TEST QUES
   PELKONEN R, 1975, BRIT MED J, V4, P85, DOI 10.1136/bmj.4.5988.85
   Rajappa M, 2006, CLIN CHIM ACTA, V372, P70, DOI 10.1016/j.cca.2006.03.019
   Rakitin A, 2016, SEIZURE-EUR J EPILEP, V38, P11, DOI 10.1016/j.seizure.2016.03.008
   Sangeetha A, 2021, NEUROL INDIA, V69, P957, DOI 10.4103/0028-3886.325371
   Schuele SU, 2009, J CLIN NEUROPHYSIOL, V26, P302, DOI 10.1097/WNP.0b013e3181b7f13b
   Shan YS, 2023, NEUROCHEM RES, V48, P2017, DOI 10.1007/s11064-023-03891-2
   Shimada T, 2014, MEDIAT INFLAMM, V2014, DOI 10.1155/2014/901902
   Simental-Mendia Luis E., 2008, Metabolic Syndrome and Related Disorders, V6, P299, DOI 10.1089/met.2008.0034
   Sonmez FM, 2006, J CHILD NEUROL, V21, P70, DOI 10.2310/7010.2006.00015
   Spitzer RL, 2006, ARCH INTERN MED, V166, P1092, DOI 10.1001/archinte.166.10.1092
   Sunitha S, 2015, INDIAN J DERMATOL VE, V81, P464, DOI 10.4103/0378-6323.163734
   Swinson Richard P, 2006, Evid Based Med, V11, P184, DOI 10.1136/ebm.11.6.184
   Vezzani A, 2011, NAT REV NEUROL, V7, P31, DOI 10.1038/nrneurol.2010.178
   YAGI K, 1984, METHOD ENZYMOL, V105, P328
NR 69
TC 1
Z9 1
U1 1
U2 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1525-5050
EI 1525-5069
J9 EPILEPSY BEHAV
JI Epilepsy Behav.
PD AUG
PY 2023
VL 145
AR 109326
DI 10.1016/j.yebeh.2023.109326
EA JUN 2023
PG 9
WC Behavioral Sciences; Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology; Psychiatry
GA M4YA2
UT WOS:001030271900001
PM 37392602
DA 2025-06-11
ER

PT S
AU Jia, GH
   Aroor, AR
   Sowers, JR
AF Jia, Guanghong
   Aroor, Annayya R.
   Sowers, James R.
BE Osiewacz, HD
TI Estrogen and Mitochondria Function in Cardiorenal Metabolic Syndrome
SO MITOCHONDRION IN AGING AND DISEASE
SE Progress in Molecular Biology and Translational Science
LA English
DT Review; Book Chapter
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; DIABETES-MELLITUS; RECEPTOR-ALPHA;
   ANGIOTENSIN-II; FEMALE MICE; BODY-FAT; DYSFUNCTION; OBESITY; BETA
AB The cardiorenal metabolic syndrome (CRS) consists of a constellation of cardiac, renal, and metabolic disorders including insulin resistance (IR), obesity, metabolic dyslipidemia, high-blood pressure, and evidence of early cardiac and renal disease. Mitochondria dysfunction often occurs in the CRS, and this dysfunction is promoted by excess reactive oxygen species, genetic factors, IR, aging, and altered mitochondrial biogenesis. Recently, it has been shown that there are important sex-related differences in mitochondria function and metabolic, cardiovascular, and renal components. Sex differences in the CRS have mainly been attributed to the estrogen's effects that are mainly mediated by estrogen receptor (ER) alpha, ER beta, and G-protein coupled receptor 30. In this review, we discuss the effects of estrogen on the mitochondrial function, insulin metabolic signaling, glucose transport, lipid metabolism, and inflammatory responses from liver, pancreatic beta cells, adipocytes, skeletal muscle, and cardiovascular tissue.
C1 [Jia, Guanghong; Aroor, Annayya R.; Sowers, James R.] Diabet Cardiovasc Ctr, Div Endocrinol Diabet & Metab, Columbia, MO 65211 USA.
   [Jia, Guanghong; Aroor, Annayya R.; Sowers, James R.] Harry S Truman Mem Vet Hosp, Columbia, MO 65201 USA.
   [Sowers, James R.] Dept Med Pharmacol & Physiol, Columbia, MO USA.
C3 University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital
RP Jia, GH (corresponding author), Diabet Cardiovasc Ctr, Div Endocrinol Diabet & Metab, Columbia, MO 65211 USA.
FU NHLBI NIH HHS [R01 HL107910, R01 HL073101, R01 HL73101] Funding Source:
   Medline
CR Aroor AR, 2013, METABOLISM, V62, P1543, DOI 10.1016/j.metabol.2013.07.001
   Aroor AR, 2012, CARDIORENAL MED, V2, P87, DOI 10.1159/000335675
   Barros RPA, 2006, P NATL ACAD SCI USA, V103, P1605, DOI 10.1073/pnas.0510391103
   Bender SB, 2013, DIABETES, V62, P313, DOI 10.2337/db12-0905
   Bhatt MP, 2013, DIABETES, V62, P3851, DOI 10.2337/db13-0039
   Brinton RD, 2008, TRENDS NEUROSCI, V31, P529, DOI 10.1016/j.tins.2008.07.003
   de Cavanagh EMV, 2011, CARDIOVASC RES, V89, P31, DOI 10.1093/cvr/cvq285
   Deenadayalu V, 2012, AM J PHYSIOL-HEART C, V302, pH115, DOI 10.1152/ajpheart.00046.2011
   DeMarco VG, 2010, WORLD J CARDIOL, V2, P316, DOI 10.4330/wjc.v2.i10.316
   Deng JY, 2008, DIABETES, V57, P1814, DOI 10.2337/db07-1750
   Dey NB, 2012, MOL CELL BIOCHEM, V368, P27, DOI 10.1007/s11010-012-1339-2
   DOLLERY CM, 1995, CIRC RES, V77, P863, DOI 10.1161/01.RES.77.5.863
   Faulds MH, 2012, J ENDOCRINOL, V212, P3, DOI 10.1530/JOE-11-0044
   Ford ES, 2010, J DIABETES, V2, P180, DOI 10.1111/j.1753-0407.2010.00078.x
   Gallagher EJ, 2010, MT SINAI J MED, V77, P511, DOI 10.1002/msj.20212
   Gao L, 2008, VET CLIN N AM-SMALL, V38, P137, DOI 10.1016/j.cvsm.2007.10.004
   Gaspard U, 2009, MATURITAS, V62, P362, DOI 10.1016/j.maturitas.2008.11.026
   Gleyzer N, 2011, J BIOL CHEM, V286, P39715, DOI 10.1074/jbc.M111.291575
   Gunter TE, 2000, CELL CALCIUM, V28, P285, DOI 10.1054/ceca.2000.0168
   Guo JB, 2012, FREE RADICAL BIO MED, V52, P2151, DOI 10.1016/j.freeradbiomed.2012.03.005
   Handgraaf S, 2013, DIABETES, V62, P4098, DOI 10.2337/db13-0282
   Hayden MR, 2005, CARDIOVASC DIABETOL, V4, DOI 10.1186/1475-2840-4-4
   Huang SY, 2013, FERTIL STERIL, V100, P234, DOI 10.1016/j.fertnstert.2013.02.052
   Jaubert AM, 2007, ENDOCRINOLOGY, V148, P2444, DOI 10.1210/en.2006-1329
   Jindal A, 2013, CURR OPIN PHARMACOL, V13, P200, DOI 10.1016/j.coph.2012.12.006
   Jindal A, 2013, CONTRIB NEPHROL, V179, P15, DOI 10.1159/000346718
   Jindal A, 2012, CARDIORENAL MED, V2, P314, DOI 10.1159/000343803
   Johannsen DL, 2009, CURR OPIN PHARMACOL, V9, P780, DOI 10.1016/j.coph.2009.09.002
   Jones MEE, 2000, P NATL ACAD SCI USA, V97, P12735, DOI 10.1073/pnas.97.23.12735
   Khalil R. A., 2010, Cardiovascular & Hematological Agents in Medicinal Chemistry, V8, P29
   Khor VK, 2010, AM J PHYSIOL-ENDOC M, V299, pE657, DOI 10.1152/ajpendo.00707.2009
   Kim JA, 2008, CIRC RES, V102, P401, DOI 10.1161/CIRCRESAHA.107.165472
   Klinge CM, 2008, J CELL BIOCHEM, V105, P1342, DOI 10.1002/jcb.21936
   Krom YD, 2007, CARDIOVASC RES, V73, P217, DOI 10.1016/j.cardiores.2006.10.024
   Lee SA, 2011, BIOCHIMIE, V93, P168, DOI 10.1016/j.biochi.2010.09.007
   Liu JK, 2009, ADV DRUG DELIVER REV, V61, P1343, DOI 10.1016/j.addr.2009.06.007
   Mandavia CH, 2013, LIFE SCI, V92, P601, DOI 10.1016/j.lfs.2012.10.028
   Manrique C, 2013, ENDOCRINOLOGY, V154, P3632, DOI 10.1210/en.2013-1256
   Martins-Maciel ER, 2013, TOXICOL LETT, V217, P82, DOI 10.1016/j.toxlet.2012.11.021
   Masood DEN, 2010, CURR DRUG METAB, V11, P693, DOI 10.2174/138920010794233477
   Matic M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057458
   Meyer MR, 2011, ACTA PHYSIOL, V203, P259, DOI 10.1111/j.1748-1716.2010.02237.x
   Miller VM, 2008, PHARMACOL REV, V60, P210, DOI 10.1124/pr.107.08002
   Neugarten J, 2013, ADV CHRONIC KIDNEY D, V20, P390, DOI 10.1053/j.ackd.2013.05.004
   Nicolson GL, 2007, J CELL BIOCHEM, V100, P1352, DOI 10.1002/jcb.21247
   Nisoli E, 2007, CIRC RES, V100, P795, DOI 10.1161/01.RES.0000259591.97107.6c
   O'Lone R, 2007, MOL ENDOCRINOL, V21, P1281, DOI 10.1210/me.2006-0497
   O'Mahony F, 2012, MOL ENDOCRINOL, V26, P2058, DOI 10.1210/me.2012-1191
   Pansini F, 2008, MENOPAUSE, V15, P112, DOI 10.1097/gme.0b013e318068b285
   Pieczenik SR, 2007, EXP MOL PATHOL, V83, P84, DOI 10.1016/j.yexmp.2006.09.008
   Rains JL, 2011, FREE RADICAL BIO MED, V50, P567, DOI 10.1016/j.freeradbiomed.2010.12.006
   Rettberg JR, 2014, FRONT NEUROENDOCRIN, V35, P8, DOI 10.1016/j.yfrne.2013.08.001
   Sack MN, 2009, J MOL CELL CARDIOL, V46, P842, DOI 10.1016/j.yjmcc.2009.02.001
   Schiff M, 2009, J INHERIT METAB DIS, V32, P684, DOI 10.1007/s10545-009-1263-0
   Shao D, 2010, MITOCHONDRION, V10, P516, DOI 10.1016/j.mito.2010.05.012
   Sharef Sharef Waadallah, 2013, Oman Med J, V28, P354, DOI 10.5001/omj.2013.101
   Shirwany NA, 2010, ACTA PHARMACOL SIN, V31, P1267, DOI 10.1038/aps.2010.123
   Simoes DCM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039183
   Simpkins JW, 2010, BBA-GEN SUBJECTS, V1800, P1113, DOI 10.1016/j.bbagen.2009.11.013
   Sivitz WI, 2010, ANTIOXID REDOX SIGN, V12, P537, DOI 10.1089/ars.2009.2531
   Sowers JR, 2013, HYPERTENSION, V61, P943, DOI 10.1161/HYPERTENSIONAHA.111.00612
   Sowers JR, 2011, CARDIORENAL MED, V1, P5, DOI 10.1159/000322822
   Sowers James R, 2007, J Cardiometab Syndr, V2, P207, DOI 10.1111/j.1559-4564.2007.06656.x
   Stubbins RE, 2012, DIABETES OBES METAB, V14, P58, DOI 10.1111/j.1463-1326.2011.01488.x
   Turner N, 2008, TRENDS ENDOCRIN MET, V19, P324, DOI 10.1016/j.tem.2008.08.001
   Vasconsuelo A, 2013, AGEING RES REV, V12, P907, DOI 10.1016/j.arr.2013.09.001
   Velarde MC, 2013, PHYSIOL GENOMICS, V45, P106, DOI 10.1152/physiolgenomics.00155.2012
   Venditti P, 2009, MOL CELL ENDOCRINOL, V305, P22, DOI 10.1016/j.mce.2009.02.009
   Wang L, 2013, CELL DEATH DIS, V4, DOI 10.1038/cddis.2013.66
   Whaley-Connell A, 2011, HYPERTENSION, V58, P991, DOI 10.1161/HYPERTENSIONAHA.111.180406
   Whaley-Connell A, 2011, REV CARDIOVASC MED, V12, P21, DOI 10.3909/ricm0555
   Xue BJ, 2013, AM J PHYSIOL-REG I, V305, pR459, DOI 10.1152/ajpregu.00222.2013
   Yu YF, 2013, SCI REP-UK, V3, DOI 10.1038/srep01866
   Zhang YM, 2012, EXP DIABETES RES, DOI 10.1155/2012/320534
NR 74
TC 27
Z9 34
U1 1
U2 11
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1877-1173
BN 978-0-12-394625-6
J9 PROG MOL BIOL TRANSL
JI Prog. Molec. Biol. Transl. Sci.
PY 2014
VL 127
BP 229
EP 249
DI 10.1016/B978-0-12-394625-6.00009-X
PG 21
WC Biochemistry & Molecular Biology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA BB1YQ
UT WOS:000341461400009
PM 25149220
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lalika, M
   Mccoy, CR
   Jones, C
   Bancos, I
   Cooper, LA
   Hayes, SN
   Johnson, MP
   Kullo, IJ
   Kumbamu, A
   Noseworthy, PA
   Patten, CA
   Singh, R
   Wi, CI
   Brewer, LC
AF Lalika, Mathias
   Mccoy, Carrie R.
   Jones, Clarence
   Bancos, Irina
   Cooper, Lisa A.
   Hayes, Sharonne N.
   Johnson, Matthew P.
   Kullo, Iftikhar J.
   Kumbamu, Ashok
   Noseworthy, Peter A.
   Patten, Christi A.
   Singh, Ravinder
   Wi, Chung-Il
   Brewer, LaPrincess C.
TI Rationale, design, and participant characteristics of the FAITH! Heart
   Health plus study: An exploration of the influence of the social
   determinants of health, stress, and structural racism on African
   American cardiovascular health
SO CONTEMPORARY CLINICAL TRIALS
LA English
DT Article
DE Cardiovascular health; Health promotion; Social determinants of health;
   Psychosocial factors; African Americans
ID RANDOMIZED PILOT TRIAL; SOCIOECONOMIC-STATUS; MENTAL-HEALTH;
   UNITED-STATES; OUTCOMES; DISCRIMINATION; ASSOCIATIONS; DISPARITIES;
   PREVALENCE; IMPACT
AB Background: African Americans (AAs) face cardiovascular health (CVH) disparities linked to systemic racism. The 2020 police killing of Mr. George Floyd in Minneapolis, Minnesota, alongside the COVID-19 pandemic, exacerbated adverse psychosocial factors affecting CVH outcomes among AAs. This manuscript describes the study protocol and participant characteristics in an ancillary study exploring the relationship between biopsychosocial factors and CVH among AAs. Methods: Using a community-based participatory approach, a mixed-methods ancillary study of 58 AA participants from an overarching randomized control trial (RCT) was conducted. Baseline RCT health assessments (November 2020) provided sociodemographic, medical, and clinical data. Subsequent health assessments (February -December 2022) measured sleep quality, psychosocial factors (e.g., high-effort coping), biomarkers (e.g., cortisol), and cardiovascular diagnostics (e.g., cardio-ankle vascular index). CVH was assessed using the American Heart Association Life's Simple 7 (LS7) (range 0 to 14, poor to ideal) and Life's Essential 8 (LE8) scores (range 0 to 100, low to high). Correlations between these scores will be examined. Focus group discussions via videoconferencing (March to April 2022) assessed psychosocial and structural barriers, along with the impact of COVID-19 and George Floyd's killing on daily life. Results: Participants were predominantly female (67%), with a mean age of 54.6 [11.9] years, high cardiometabolic risk (93% had overweight/obesity and 70% hypertension), and moderate LE8 scores (mean 57.4, SD 11.5). Conclusion: This study will enhance understanding of the associations between biopsychosocial factors and CVH among AAs in Minnesota. Findings may inform risk estimation, patient care, and healthcare policies to address CVD disparities in marginalized populations.
C1 [Bancos, Irina; Brewer, LaPrincess C.] Mayo Clin, Coll Med, Dept Cardiovasc Med, 200 First St SW, Rochester, MN 55905 USA.
   [Cooper, Lisa A.] Hue Man Partnership, 2400 Pk Ave, Minneapolis, MN 55404 USA.
   [Johnson, Matthew P.] Mayo Clin, Coll Med, Div Endocrinol Diabet Metab & Nutr, 200 First St SW, Rochester, MN 55905 USA.
   [Kumbamu, Ashok] Johns Hopkins Univ, Sch Med, Dept Med, 2024 E Monument St,Suite 2-500, Baltimore, MD 21205 USA.
   [Patten, Christi A.] Mayo Clin, Dept Quantitat Hlth Sci, 200 First St SW, Rochester, MN 55905 USA.
   [Singh, Ravinder] Mayo Clin, Robert D & Patricia E Kern Ctr Sci Hlth Care Deliv, 200 First St SW, Rochester, MN 55905 USA.
   [Patten, Christi A.; Wi, Chung-Il] Mayo Clin, Coll Med, Dept Psychiat & Psychol, 200 First St SW, Rochester, MN 55905 USA.
   [Singh, Ravinder; Brewer, LaPrincess C.] Mayo Clin, Dept Lab Med & Pathol, Div Clin Biochem & Immunol, 200 First St SW, Rochester, MN 55905 USA.
   [Wi, Chung-Il] Mayo Clin, Dept Pediat & Adolescent Med, 200 First St SW, Rochester, MN 55905 USA.
   [Brewer, LaPrincess C.] Mayo Clin, Ctr Hlth Equ & Community Engagement Res, 200 First St SW, Rochester, MN 55905 USA.
C3 Mayo Clinic; Mayo Clinic; Johns Hopkins University; Mayo Clinic; Mayo
   Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic
RP Brewer, LC (corresponding author), Mayo Clin, Coll Med, Dept Cardiovasc Med, 200 First St SW, Rochester, MN 55905 USA.
EM Lalika.Mathias@mayo.edu; mccoy.carrie@mayo.edu; Bancos.Irina@mayo.edu;
   lisa.cooper@jhmi.edu; Hayes.Sharonne@mayo.edu;
   johnson.matthew5@mayo.edu; Kullo.Iftikhar@mayo.edu;
   Kumbamu.Ashok@mayo.edu; Noseworthy.Peter@mayo.edu;
   Patten.Christi@mayo.edu; Singh.Ravinder@mayo.edu;
   brewer.laprincess@mayo.edu
RI Bancos, Irina/J-6560-2019
FU National Center for Advancing Translational Sci-ences (NCATS)
   [TR000135]; Mayo Clinic Center for Health Equity and Community
   Engagement in Research; Mayo Clinic Chief Executive Office; American
   Heart As-sociation-Amos Medical Faculty Development Program
   [19AMFDP35040005]; American Heart Association Second Century
   Implementation Science Award; NCATS (CTSA) [23SCISA1144689];
   Bristol-Myers Squibb Foundation [KL2 TR002379]; Centers for Disease
   Control and Prevention (CDC) [CDC-DP18-1817]; NIH/NIMHD P50 Center for
   Chronic Disease Reduction and Equity Promotion Across Minnesota;
   Pro-gram [C2DREAM]; American Heart Association through the Research
   Supplement to Promote Diversity in Science [P50MD017342]; Mayo Clinic
   NIH T32 Training Program [23DIVSUP1067167];  [T32 HL07111]; American
   Heart Association (AHA) [23DIVSUP1067167] Funding Source: American Heart
   Association (AHA)
FX The research reported herein was supported by the National Institutes of
   Health (NIH)/National Institute on Minority Health and Health
   Disparities (NIMHD) (Grant No. 1 R21 MD013490-01), the Clinical and
   Translational Science Awards (CTSA) (Grant No. UL1TR000135) from the
   National Center for Advancing Translational Sciences (NCATS) to Mayo
   Clinic, the Mayo Clinic Center for Health Equity and Community
   Engagement in Research and the Mayo Clinic Chief Executive Office. Dr.
   Brewer was supported by the American Heart Association-Amos Medical
   Faculty Development Program (Grant No. 19AMFDP35040005), American Heart
   Association Second Century Implementation Science Award (Grant No.
   23SCISA1144689), NCATS (CTSA Grant No. KL2 TR002379), the Bristol-Myers
   Squibb Foundation and the Centers for Disease Control and Prevention
   (CDC, Grant No. CDC-DP18-1817) and the NIH/NIMHD P50 Center for Chronic
   Disease Reduction and Equity Promotion Across Minnesota (C2DREAM)
   Program (Grant No. P50MD017342) during the implementation of this work.
   Dr. Lalika received funding from the American Heart Association through
   the Research Supplement to Promote Diversity in Science (Grant No.
   23DIVSUP1067167), while Dr. McCoy was funded by the Mayo Clinic NIH T32
   Training Program (Grant No. T32 HL07111). Its contents are solely the
   responsibility of the authors and do not neces-sarily represent the
   official views of NCATS, NIH, or CDC. The funding bodies had no role in
   study design; in the collection, analysis, and interpretation of data;
   writing of the manuscript; and in the decision to submit the manuscript
   for publication.r TR000135) from the National Center for Advancing
   Translational Sci-ences (NCATS) to Mayo Clinic, the Mayo Clinic Center
   for Health Equity and Community Engagement in Research and the Mayo
   Clinic Chief Executive Office. Dr. Brewer was supported by the American
   Heart As-sociation-Amos Medical Faculty Development Program (Grant No.
   19AMFDP35040005) , American Heart Association Second Century
   Implementation Science Award (Grant No. 23SCISA1144689) , NCATS (CTSA
   Grant No. KL2 TR002379) , the Bristol-Myers Squibb Foundation and the
   Centers for Disease Control and Prevention (CDC, Grant No.
   CDC-DP18-1817) and the NIH/NIMHD P50 Center for Chronic Disease
   Reduction and Equity Promotion Across Minnesota (C2DREAM) Pro-gram
   (Grant No. P50MD017342) during the implementation of this work. Dr.
   Lalika received funding from the American Heart Association through the
   Research Supplement to Promote Diversity in Science (Grant No.
   23DIVSUP1067167) , while Dr. McCoy was funded by the Mayo Clinic NIH T32
   Training Program (Grant No. T32 HL07111) . Its contents are solely the
   responsibility of the authors and do not neces-sarily represent the
   official views of NCATS, NIH, or CDC. The funding bodies had no role in
   study design; in the collection, analysis, and interpretation of data;
   writing of the manuscript; and in the decision to submit the manuscript
   for publication.
CR Adam EK, 2017, PSYCHONEUROENDOCRINO, V83, P25, DOI 10.1016/j.psyneuen.2017.05.018
   Aggarwal G, 2020, CURR PROB CARDIOLOGY, V45, DOI 10.1016/j.cpcardiol.2020.100617
   Allen AM, 2019, ANN NY ACAD SCI, V1457, P104, DOI 10.1111/nyas.14188
   Bang DW, 2014, INT J ENV RES PUB HE, V11, P11597, DOI 10.3390/ijerph111111597
   Barajas CB, 2019, J COMMUN HEALTH, V44, P954, DOI 10.1007/s10900-019-00650-9
   Barwise A, 2021, J INTENSIVE CARE MED, V36, P828, DOI 10.1177/0885066620931020
   Bennett GG, 2004, PSYCHOL HEALTH, V19, P369, DOI 10.1080/0887044042000193505
   Brewer LC, 2022, CIRCULATION, V146, P175, DOI 10.1161/CIRCULATIONAHA.122.059046
   Brewer LC, 2022, AM HEART J, V247, P1, DOI 10.1016/j.ahj.2022.01.009
   Brewer LC, 2019, J GEN INTERN MED, V34, P1376, DOI 10.1007/s11606-019-04936-5
   Brewer LC, 2018, J AM HEART ASSOC, V7, DOI 10.1161/JAHA.118.008855
   Buie JNJ, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0216213
   Buysse DJ, 2014, SLEEP, V37, P9, DOI 10.5665/sleep.3298
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1016/0165-1781(89)90047-4
   Canady RB, 2009, J NURS MEAS, V17, P91, DOI 10.1891/1061-3749.17.2.91
   Carnethon MR, 2017, CIRCULATION, V136, pE393, DOI 10.1161/CIR.0000000000000534
   Chang K.-T., 2011, Introduction to Geographic Information Systems
   Duval S, 2020, CLIN EPIDEMIOL, V12, P41, DOI 10.2147/CLEP.S219708
   Elo S, 2008, J ADV NURS, V62, P107, DOI 10.1111/j.1365-2648.2007.04569.x
   Felix AS, 2019, CIRC-CARDIOVASC QUAL, V12, DOI 10.1161/CIRCOUTCOMES.118.005284
   Freedman AA, 2022, SCI ADV, V8, DOI 10.1126/sciadv.abl5417
   Grosicki GJ, 2022, PROG CARDIOVASC DIS, V71, P4, DOI 10.1016/j.pcad.2022.04.004
   Guhl EN, 2021, J CARDIOPULM REHABIL, V41, P315, DOI 10.1097/HCR.0000000000000591
   Harmon DM, 2022, AM J PREVENT CARDIOL, V12, DOI 10.1016/j.ajpc.2022.100431
   Haynes N, 2022, CURR EPIDEMIOL REP, V9, P212, DOI 10.1007/s40471-022-00298-5
   healthmeasures healthmeasures, PROMIS Anxiety Scoring Manual
   Hicken Margaret T, 2013, Race Soc Probl, V5, P100
   Hilvo M, 2020, EUR HEART J, V41, P371, DOI 10.1093/eurheartj/ehz387
   Jackson James S, 2002, ICPSR, V1
   Johnson AE, 2022, J AM HEART ASSOC, V11, DOI 10.1161/JAHA.121.023438
   Joseph JJ, 2023, J AM HEART ASSOC, V12, DOI 10.1161/JAHA.123.030695
   Juhn YJ, 2011, J URBAN HEALTH, V88, P933, DOI 10.1007/s11524-011-9572-7
   Kershaw KN, 2024, CIRC-CARDIOVASC QUAL, V17, DOI 10.1161/HCQ.0000000000000124
   Kessler RC, 1999, J HEALTH SOC BEHAV, V40, P208, DOI 10.2307/2676349
   Khan I, 2023, JAMA NETW OPEN, V6, DOI 10.1001/jamanetworkopen.2023.34836
   Kiger ME, 2020, MED TEACH, V42, P846, DOI 10.1080/0142159X.2020.1755030
   Kodali HP, 2024, JAMA NETW OPEN, V7, DOI 10.1001/jamanetworkopen.2024.1429
   Kwok CS, 2018, J AM HEART ASSOC, V7, DOI 10.1161/JAHA.118.008552
   Kyalwazi AN, 2022, CIRCULATION, V146, P211, DOI 10.1161/CIRCULATIONAHA.122.060199
   LaVeist TA, 2023, JAMA-J AM MED ASSOC, V329, P1682, DOI 10.1001/jama.2023.5965
   Lewis TT, 2023, HEALTH PSYCHOL, V42, P485, DOI 10.1037/hea0001309
   Lloyd-Jones DM, 2022, CIRCULATION, V146, P822, DOI 10.1161/CIRCULATIONAHA.122.060911
   Lloyd-Jones DM, 2022, CIRCULATION, V146, pE18, DOI 10.1161/CIR.0000000000001078
   Lloyd-Jones DM, 2010, CIRCULATION, V121, P586, DOI 10.1161/CIRCULATIONAHA.109.192703
   Lunyera J, 2018, CLIN J AM SOC NEPHRO, V13, P213, DOI 10.2215/CJN.06430617
   Manjunath C, 2021, AM J PREVENT CARDIOL, V8, DOI 10.1016/j.ajpc.2021.100254
   Manjunath C, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16214144
   Mannoh I, 2021, CURR OPIN CARDIOL, V36, P572, DOI 10.1097/HCO.0000000000000893
   Martin KS, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094033
   Mielke MM, 2015, AGING CELL, V14, P1014, DOI 10.1111/acel.12369
   Minnesota Department of Health, Cardiovascular Health and Diabetes Prevalence in Minnesota
   Moody DLB, 2018, PSYCHOSOM MED, V80, P114, DOI 10.1097/PSY.0000000000000516
   Mujahid Mahasin S, 2021, Proc Natl Acad Sci U S A, V118, DOI 10.1073/pnas.2110986118
   Ortiz R, 2022, COMPR PSYCHONEUROEND, V11, DOI 10.1016/j.cpnec.2022.100145
   Payne TJ, 2005, ETHNIC DIS, V15, pS38
   Perez AD, 2023, SOC SCI MED, V316, DOI 10.1016/j.socscimed.2022.115070
   Peterson PN, 2020, J AM HEART ASSOC, V9, DOI 10.1161/JAHA.120.017112
   Rodriguez F, 2021, CIRCULATION, V143, P2332, DOI 10.1161/CIRCULATIONAHA.120.052278
   Shah NS, 2023, CIRCULATION, V147, P190, DOI 10.1161/CIRCULATIONAHA.122.061991
   Sherman MD, 2019, FAM MED, V51, P677, DOI 10.22454/FamMed.2019.947255
   Smyth N, 2016, PSYCHONEUROENDOCRINO, V74, P380, DOI 10.1016/j.psyneuen.2016.09.026
   Son H, 2023, J AM HEART ASSOC, V12, DOI 10.1161/JAHA.122.026940
   South EC, 2023, JAMA INTERN MED, V183, P31, DOI 10.1001/jamainternmed.2022.5460
   Stevens MA, 2020, TRANSPLANTATION, V104, P2383, DOI 10.1097/TP.0000000000003131
   Tabb LP, 2020, J AM HEART ASSOC, V9, DOI 10.1161/JAHA.120.016556
   Tadese K, 2024, HEALTH PROMOT PRACT, V25, P8, DOI 10.1177/15248399221118394
   Tai DBG, 2021, CLIN INFECT DIS, V72, P703, DOI 10.1093/cid/ciaa815
   Talbert RD, 2023, J RACIAL ETHN HEALTH, V10, P1756, DOI 10.1007/s40615-022-01359-7
   Tiako MJN, 2024, JAMA NETW OPEN, V7, DOI 10.1001/jamanetworkopen.2024.1405
   Vela MB, 2022, ANNU REV PUBL HEALTH, V43, P477, DOI 10.1146/annurev-publhealth-052620-103528
   Wadhera RK, 2021, CIRCULATION, V143, P2346, DOI 10.1161/CIRCULATIONAHA.121.054378
   Wi CI, 2016, MAYO CLIN PROC, V91, P612, DOI 10.1016/j.mayocp.2016.02.011
   Williams A, 2023, J AM HEART ASSOC, V12, DOI 10.1161/JAHA.122.029254
   Williams DR, 2018, J HEALTH SOC BEHAV, V59, P466, DOI 10.1177/0022146518814251
   Williams MT, 2018, PSYCHOL VIOLENCE, V8, P735, DOI 10.1037/vio0000212
   Williams PC, 2021, J EXPO SCI ENV EPID, V31, P412, DOI 10.1038/s41370-021-00313-9
   Woods-Giscombe CL, 2019, ISSUES MENT HEALTH N, V40, P672, DOI 10.1080/01612840.2019.1584654
   Woods-Giscombé CL, 2010, QUAL HEALTH RES, V20, P668, DOI 10.1177/1049732310361892
   Zahodne LB, 2023, SOC SCI MED, V316, DOI 10.1016/j.socscimed.2022.114789
NR 79
TC 2
Z9 2
U1 1
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1551-7144
EI 1559-2030
J9 CONTEMP CLIN TRIALS
JI Contemp. Clin. Trials
PD AUG
PY 2024
VL 143
AR 107600
DI 10.1016/j.cct.2024.107600
EA JUN 2024
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA XB1N8
UT WOS:001259133500001
PM 38851481
DA 2025-06-11
ER

PT J
AU Fan, J
   Wang, DX
AF Fan, Jia
   Wang, Dongxu
TI Serum uric acid and nonalcoholic fatty liver disease
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE nonalcoholic fatty liver disease; serum uric acid; xanthine oxidase;
   oxidative stress; NLRP3 inflammasome; lipid metabolism; insulin
   resistance
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; HEPATIC STEATOSIS; INFLAMMATION;
   ASSOCIATION; OBESITY; RISK; LEVEL; HYPERURICEMIA; ACCUMULATION
AB Nonalcoholic fatty liver disease (NAFLD) is characterized by over 5% hepatic fat accumulation without secondary causes. The prevalence of NAFLD has escalated in recent years due to shifts in dietary patterns and socioeconomic status, making it the most prevalent chronic liver disease and a significant public health concern globally. Serum uric acid (SUA) serves as the end product of purine metabolism in the body and is intricately linked to metabolic syndrome. Elevated SUA levels have been identified as an independent risk factor for the incidence and progression of NAFLD. This paper reviews the relationship between SUA and NAFLD, the underlying mechanisms of SUA involved in NAFLD, and the potential benefits of SUA-lowering therapy in treating NAFLD. The aim is to raise awareness of SUA management in patients with NAFLD, and to encourage further investigation into pharmacological interventions in this area.
C1 [Fan, Jia; Wang, Dongxu] China Med Univ, Dept Gastroenterol, Shengjing Hosp, Shenyang, Peoples R China.
C3 China Medical University
RP Wang, DX (corresponding author), China Med Univ, Dept Gastroenterol, Shengjing Hosp, Shenyang, Peoples R China.
EM dongxuwangdx@126.com
FU Liaoning Provincial Science and Technology Programme Joint Fund for
   Doctoral Research Initiation Project [2023-BSBA-349]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This research was funded
   by Liaoning Provincial Science and Technology Programme Joint Fund for
   Doctoral Research Initiation Project, grant number 2023-BSBA-349.
CR Abbasi Sarwat, 2019, J Ayub Med Coll Abbottabad, V31, P64
   Adams LA, 2017, GUT, V66, P1138, DOI 10.1136/gutjnl-2017-313884
   Afzali A, 2010, HEPATOLOGY, V52, P578, DOI 10.1002/hep.23717
   Al-Shargi A, 2023, BIOMEDICINES, V11, DOI 10.3390/biomedicines11113074
   Aoyama Y, 2022, NUTRIENTS, V14, DOI 10.3390/nu14010042
   Bai J X, 2018, Zhonghua Gan Zang Bing Za Zhi, V26, P271, DOI 10.3760/cma.j.issn.1007-3418.2018.04.008
   Ballestri S, 2016, HEPATOL RES, V46, P1074, DOI 10.1111/hepr.12656
   Bao T, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-66931-9
   Barisik V, 2023, ACTA ENDOCRINOL-BUCH, V19, P155, DOI 10.4183/aeb.2023.155
   Brennan P, 2020, WORLD J GASTROENTERO, V26, P1683, DOI 10.3748/wjg.v26.i15.1683
   Buzzetti E, 2016, METABOLISM, V65, P1038, DOI 10.1016/j.metabol.2015.12.012
   Cai W, 2013, ARQ BRAS ENDOCRINOL, V57, P617, DOI 10.1590/S0004-27302013000800006
   Catanzaro R, 2022, ACTA CLIN BELG, V77, P45, DOI 10.1080/17843286.2020.1783907
   Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI 10.1002/hep.29367
   Chen SH, 2020, BMC GASTROENTEROL, V20, DOI 10.1186/s12876-020-01189-z
   Chen YL, 2021, BMC GASTROENTEROL, V21, DOI 10.1186/s12876-021-01782-w
   Chhatwal J, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2022.30426
   Cho IJ, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-88872-7
   Choi A, 2022, J DIABETES RES, V2022, DOI 10.1155/2022/9537741
   Choi YJ, 2014, LAB INVEST, V94, P1114, DOI 10.1038/labinvest.2014.98
   Chu X, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/5180242
   Cong FY, 2023, BMC GASTROENTEROL, V23, DOI 10.1186/s12876-023-02708-4
   Cui YL, 2021, J DIABETES COMPLICAT, V35, DOI 10.1016/j.jdiacomp.2021.107874
   Deng AH, 2022, BMC COMPLEMENT MED, V22, DOI 10.1186/s12906-022-03794-9
   Ding YJ, 2023, SAUDI J GASTROENTERO, V29, P191, DOI 10.4103/sjg.sjg_484_22
   El Din UAAS, 2017, J ADV RES, V8, P537, DOI 10.1016/j.jare.2016.11.004
   Francey C, 2019, CLIN NUTR ESPEN, V29, P125, DOI 10.1016/j.clnesp.2018.11.008
   Gonzalez A, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/1617805
   Han RF, 2022, DIABET METAB SYND OB, V15, P1461, DOI 10.2147/DMSO.S362248
   He J, 2022, NUTRIENTS, V14, DOI 10.3390/nu14173587
   Hong T, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/6889533
   Hossain I A, 2016, Trop Gastroenterol, V37, P101
   Hotamisligil GS, 2008, NAT REV IMMUNOL, V8, P923, DOI 10.1038/nri2449
   Hu YM, 2021, PEERJ, V9, DOI 10.7717/peerj.10691
   Huang Q, 2016, BIOMED REP, V5, P188, DOI 10.3892/br.2016.698
   Hwang IC, 2011, J KOREAN MED SCI, V26, P386, DOI 10.3346/jkms.2011.26.3.386
   Itabashi F, 2022, J EPIDEMIOL, V32, P221, DOI 10.2188/jea.JE20200384
   Kakimoto M, 2023, J APPL BIOMED, V21, P80, DOI 10.32725/jab.2023.009
   Katsiki N, 2021, CURR PHARM DESIGN, V27, P1941, DOI 10.2174/1381612827666210104124320
   Kawano Y, 2013, J GASTROENTEROL, V48, P434, DOI 10.1007/s00535-013-0758-5
   Kono H, 2010, J CLIN INVEST, V120, P1939, DOI 10.1172/JCI40124
   Kuo CF, 2010, SCAND J RHEUMATOL, V39, P466, DOI 10.3109/03009741003742797
   Lanaspa MA, 2012, J BIOL CHEM, V287, P40732, DOI 10.1074/jbc.M112.399899
   Laursen TL, 2019, WORLD J HEPATOL, V11, P138, DOI 10.4254/wjh.v11.i2.138
   Lee J, 2022, CLIN MOL HEPATOL, V28, P196, DOI 10.3350/cmh.2021.0371
   Lee JS, 2019, J RHEUMATOL, V46, P527, DOI 10.3899/jrheum.180761
   Li AA, 2020, GUT LIVER, V14, P168, DOI 10.5009/gnl19069
   Li CG, 2013, CURR OPIN RHEUMATOL, V25, P210, DOI 10.1097/BOR.0b013e32835d951e
   Li J, 2019, LANCET GASTROENTEROL, V4, P389, DOI 10.1016/S2468-1253(19)30039-1
   Li XC, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00049
   Li YM, 2009, J HEPATOL, V50, P1029, DOI 10.1016/j.jhep.2008.11.021
   Liang J, 2015, EUR REV MED PHARMACO, V19, P305
   Lima WG, 2015, BIOCHIMIE, V116, P17, DOI 10.1016/j.biochi.2015.06.025
   Lin HD, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0140379
   Liu J, 2021, TOXICOL SCI, V181, P295, DOI 10.1093/toxsci/kfab034
   Liu J, 2017, HEPATOL RES, V47, pE104, DOI 10.1111/hepr.12734
   Liu PJ, 2014, CLIMACTERIC, V17, P692, DOI 10.3109/13697137.2014.926323
   Lou BW, 2023, J TRANSL MED, V21, DOI 10.1186/s12967-023-04050-5
   Lv HH, 2023, NUTRIENTS, V15, DOI 10.3390/nu15061355
   Ma ZM, 2020, J TRANSL MED, V18, DOI 10.1186/s12967-020-02296-x
   Nakatsu Y, 2015, AM J PHYSIOL-GASTR L, V309, pG42, DOI 10.1152/ajpgi.00443.2014
   Nishikawa T, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-57784-3
   Nogueira Juan Patricio, 2024, Diabetes Spectr, V37, P20, DOI 10.2337/dsi23-0013
   Odegaard JI, 2008, NAT CLIN PRACT ENDOC, V4, P619, DOI 10.1038/ncpendmet0976
   Olefsky JM, 2010, ANNU REV PHYSIOL, V72, P219, DOI 10.1146/annurev-physiol-021909-135846
   Oral A, 2019, MEDICINA-LITHUANIA, V55, DOI 10.3390/medicina55090600
   Ozcelik F, 2016, LIVER INT, V36, P768, DOI 10.1111/liv.13063
   Park H, 2022, ASIAN BIOMED, V16, P15, DOI 10.2478/abm-2022-0003
   Polyzos SA, 2019, METABOLISM, V92, P82, DOI 10.1016/j.metabol.2018.11.014
   Portincasa P, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25115640
   Rock KL, 2011, IMMUNOL REV, V243, P191, DOI 10.1111/j.1600-065X.2011.01040.x
   Ryu S, 2011, METABOLISM, V60, P860, DOI 10.1016/j.metabol.2010.08.005
   Saha T, 2020, ACS OMEGA, V5, P16342, DOI 10.1021/acsomega.9b04079
   Sanchez-Lozada LG, 2019, J BIOL CHEM, V294, P4272, DOI 10.1074/jbc.RA118.006158
   Sandra S, 2019, DIAB MET SYND CLIN R, V13, P424, DOI 10.1016/j.dsx.2018.10.001
   Savari F, 2024, HELIYON, V10, DOI 10.1016/j.heliyon.2024.e28468
   Sertoglu E, 2014, CLIN BIOCHEM, V47, P383, DOI 10.1016/j.clinbiochem.2014.01.029
   Shi Y, 2003, NATURE, V425, P516, DOI 10.1038/nature01991
   Shih MH, 2015, J FORMOS MED ASSOC, V114, P314, DOI 10.1016/j.jfma.2012.11.014
   Shoelson SE, 2007, GASTROENTEROLOGY, V132, P2169, DOI 10.1053/j.gastro.2007.03.059
   Sirota JC, 2013, METABOLISM, V62, P392, DOI 10.1016/j.metabol.2012.08.013
   Soliman MM, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-66205-4
   Spiga R, 2017, ARTERIOSCL THROM VAS, V37, P1241, DOI 10.1161/ATVBAHA.117.309128
   Stienstra R, 2011, P NATL ACAD SCI USA, V108, P15324, DOI 10.1073/pnas.1100255108
   Sun DQ, 2016, EXPERT OPIN THER TAR, V20, P375, DOI 10.1517/14728222.2016.1096930
   Sun QJ, 2023, CLIN EPIDEMIOL, V15, P683, DOI 10.2147/CLEP.S403314
   Tan CH, 2018, SURG OBES RELAT DIS, V14, P1600, DOI 10.1016/j.soard.2018.05.024
   Tang W, 2018, J BIOL REG HOMEOS AG, V32, P545
   Tang Yuhan, 2022, Oxid Med Cell Longev, V2022, P6687626, DOI 10.1155/2022/6687626
   Tsai CC, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-01274-y
   Vandanmagsar B, 2011, NAT MED, V17, P179, DOI 10.1038/nm.2279
   Vilar-Gomez E, 2015, GASTROENTEROLOGY, V149, P367, DOI 10.1053/j.gastro.2015.04.005
   Wan XY, 2016, J HEPATOL, V64, P925, DOI 10.1016/j.jhep.2015.11.022
   Wang HC, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.1018572
   Wang M, 2022, PEERJ, V10, DOI 10.7717/peerj.13022
   Wang W, 2013, BRIT J PHARMACOL, V169, P1352, DOI 10.1111/bph.12226
   Wang XC, 2022, CELL DEATH DISCOV, V8, DOI 10.1038/s41420-022-01011-7
   Wei FJ, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00179
   Wu SJ, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000000802
   Wu XQ, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01728
   Xie D., 2021, AM J PHYSIOL-ENDOC M, V320, pE1032, DOI [10.1152/ajpendo.00518.2020, DOI 10.1152/ajpendo.00518.2020]
   Xie YL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0067152
   Xu CF, 2016, HEPATOL INT, V10, P286, DOI 10.1007/s12072-015-9682-5
   Xu CF, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011578
   Yang C, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0192396
   Yang C, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0177249
   Yang HH, 2018, J TRANSL MED, V16, DOI 10.1186/s12967-018-1657-6
   Yen PC, 2022, J CLIN MED, V11, DOI 10.3390/jcm11051445
   Yoo TW, 2005, CIRC J, V69, P928, DOI 10.1253/circj.69.928
   Younossi ZM, 2023, HEPATOLOGY, V77, P1335, DOI 10.1097/HEP.0000000000000004
   Yu XL, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000008164
   Yuan HP, 2015, J CLIN ENDOCR METAB, V100, P4198, DOI 10.1210/jc.2015-2527
   Zeng F, 2021, INT J IMMUNOPATH PH, V35, DOI 10.1177/20587384211031417
   Zeng YP, 2022, DIS MARKERS, V2022, DOI 10.1155/2022/1254014
   Zhao HR, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.931087
   Zheng XY, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0531-5
   Zhou ZW, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0166072
   Zhu YZ, 2014, BIOCHEM BIOPH RES CO, V447, P707, DOI 10.1016/j.bbrc.2014.04.080
NR 118
TC 1
Z9 1
U1 9
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD NOV 28
PY 2024
VL 15
AR 1455132
DI 10.3389/fendo.2024.1455132
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA P0U5I
UT WOS:001375169600001
PM 39669496
OA gold
DA 2025-06-11
ER

PT S
AU Jheng, HF
   Huang, SH
   Kuo, HM
   Hughes, MW
   Tsai, YS
AF Jheng, Huei-Fen
   Huang, Shin-Han
   Kuo, Hsueh-Maio
   Hughes, Michael W.
   Tsai, Yau-Sheng
GP NY Acad Sci
TI Molecular insight and pharmacological approaches targeting mitochondrial
   dynamics in skeletal muscle during obesity
SO MITOCHONDRIAL RESEARCH IN TRANSLATIONAL MEDICINE
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 11th Conference of the
   Asian-Society-for-Mitochondrial-Research-and-Medicine - From Bench to
   Clinic (ASMRM)
CY NOV 14-15, 2014
CL Taipei, TAIWAN
SP Asian Soc Mitochondrial Res & Med
DE lipid accumulation; posttranslational modification; mitochondrial
   morphology; insulin resistance; skeletal muscle
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; MITOFUSIN 2; MAMMALIAN-CELLS;
   METABOLIC SYNDROME; CANCER-CELLS; FATTY-ACIDS; E3 LIGASE; FISSION; DRP1
AB Obesity-associated insulin resistance is the major characteristic of the early stage of metabolic syndrome. A decline in mitochondrial function plays a role in the development of insulin resistance in obesity and type 2 diabetes. Accumulating data reveal that mitochondrial dynamics, the balance betweenmitochondrial fusion and fission, are an important factor in the maintenance of mitochondrial function. Thus, the mechanisms underlying the regulation of mitochondrial dynamics in obesity deserve further investigation. This review describes an overview of mitochondrial fusion and fission machineries, and discusses the mechanistic and functional aspects of mitochondrial dynamics, with a focus on skeletal muscle in obesity. Finally, we discuss current pharmacological approaches of targeting mitochondrial dynamics. Elucidating the role of mitochondrial dynamics in skeletal muscle afflicted by obesity may provide not only important clues in understanding muscle insulin resistance, but also new therapeutic targets.
C1 [Jheng, Huei-Fen; Huang, Shin-Han; Kuo, Hsueh-Maio; Hughes, Michael W.; Tsai, Yau-Sheng] Natl Cheng Kung Univ Hosp, Inst Clin Med, Tainan 70428, Taiwan.
   [Hughes, Michael W.] Natl Cheng Kung Univ, Int Res Ctr Wound Repair & Regenerat, Tainan 701, Taiwan.
   [Tsai, Yau-Sheng] Natl Cheng Kung Univ, Res Ctr Clin Med, Tainan 701, Taiwan.
C3 National Cheng Kung University; National Cheng Kung University Hospital;
   National Cheng Kung University; National Cheng Kung University
RP Tsai, YS (corresponding author), Natl Cheng Kung Univ, Inst Clin Med, 1 Univ Rd, Tainan 701, Taiwan.
EM yaustsai@mail.ncku.edu.tw
OI Hughes, Michael W./0000-0002-8899-9773
FU National Science Council [NSC-101-2320-B-006-036]; National Health
   Research Institutes [NHRI-EX104-10231SI]; National Cheng Kung University
   Aim for the Top University Project
FX This work was supported by grants from the National Science Council
   (NSC-101-2320-B-006-036), National Health Research Institutes
   (NHRI-EX104-10231SI), and National Cheng Kung University Aim for the Top
   University Project.
CR Akita M, 2014, INT J ONCOL, V45, P1901, DOI 10.3892/ijo.2014.2608
   Anderson KA, 2012, ESSAYS BIOCHEM, V52, P23, DOI [10.1042/bse0520023, 10.1042/BSE0520023]
   Bach D, 2005, DIABETES, V54, P2685, DOI 10.2337/diabetes.54.9.2685
   Bach D, 2003, J BIOL CHEM, V278, P17190, DOI 10.1074/jbc.M212754200
   Bonnard C, 2008, J CLIN INVEST, V118, P789, DOI 10.1172/JCI32601
   Braschi E, 2009, EMBO REP, V10, P748, DOI 10.1038/embor.2009.86
   Brooks C, 2009, J CLIN INVEST, V119, P1275, DOI 10.1172/JCI37829
   Butkinaree C, 2010, BBA-GEN SUBJECTS, V1800, P96, DOI 10.1016/j.bbagen.2009.07.018
   Cao K, 2014, FREE RADICAL BIO MED, V67, P396, DOI 10.1016/j.freeradbiomed.2013.11.029
   Cartoni R, 2005, J PHYSIOL-LONDON, V567, P349, DOI 10.1113/jphysiol.2005.092031
   Cassidy-Stone A, 2008, DEV CELL, V14, P193, DOI 10.1016/j.devcel.2007.11.019
   Chen Y, 2013, SCIENCE, V340, P471, DOI 10.1126/science.1231031
   Cho DH, 2009, SCIENCE, V324, P102, DOI 10.1126/science.1171091
   Cipolat S, 2004, P NATL ACAD SCI USA, V101, P15927, DOI 10.1073/pnas.0407043101
   Coen PM, 2012, TRENDS ENDOCRIN MET, V23, P391, DOI 10.1016/j.tem.2012.05.009
   Crunkhorn S, 2007, J BIOL CHEM, V282, P15439, DOI 10.1074/jbc.M611214200
   DeFronzo RA, 2009, DIABETES CARE, V32, pS157, DOI 10.2337/dc09-S302
   del Campo A, 2014, AM J PHYSIOL-ENDOC M, V306, pE1, DOI 10.1152/ajpendo.00146.2013
   Ducommun S, 2015, CELL SIGNAL, V27, P978, DOI 10.1016/j.cellsig.2015.02.008
   Echtay KS, 2002, NATURE, V415, P96, DOI 10.1038/415096a
   Evans JL, 2005, ANTIOXID REDOX SIGN, V7, P1040, DOI 10.1089/ars.2005.7.1040
   Fealy C. E., 2014, J APPL PHYSIOL, V117, P239
   Ferreira R, 2010, PROTEOMICS, V10, P3142, DOI 10.1002/pmic.201000173
   Galloway CA, 2012, DIABETES, V61, P2093, DOI 10.2337/db11-1640
   Gao DC, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0060967
   Guo X, 2014, BIOCHEM J, V461, P137, DOI 10.1042/BJ20131438
   Han XJ, 2008, J CELL BIOL, V182, P573, DOI 10.1083/jcb.200802164
   Head B, 2009, J CELL BIOL, V187, P959, DOI 10.1083/jcb.200906083
   Hirabara SM, 2010, J CELL PHYSIOL, V222, P187, DOI 10.1002/jcp.21936
   Hirschey MD, 2011, MOL CELL, V44, P177, DOI 10.1016/j.molcel.2011.07.019
   Holmström MH, 2012, AM J PHYSIOL-ENDOC M, V302, pE731, DOI 10.1152/ajpendo.00159.2011
   Ikeda Y, 2015, CIRC RES, V116, P264, DOI 10.1161/CIRCRESAHA.116.303356
   Hernández-Alvarez MI, 2010, DIABETES CARE, V33, P645, DOI 10.2337/dc09-1305
   Itoyama A, 2012, J CELL SCI, V125, P589, DOI 10.1242/jcs.087452
   Jahani-Asl A, 2007, EMBO REP, V8, P912, DOI 10.1038/sj.embor.7401077
   Jheng HF, 2012, MOL CELL BIOL, V32, P309, DOI 10.1128/MCB.05603-11
   Kahn BB, 2000, J CLIN INVEST, V106, P473, DOI 10.1172/JCI10842
   Kelley DE, 2002, DIABETES, V51, P2944, DOI 10.2337/diabetes.51.10.2944
   Kim B, 2013, AM J PHYSIOL-REG I, V305, pR927, DOI 10.1152/ajpregu.00502.2012
   Kong DX, 2013, MOL MED REP, V8, P205, DOI 10.3892/mmr.2013.1457
   Koves TR, 2005, AM J PHYSIOL-CELL PH, V288, pC1074, DOI 10.1152/ajpcell.00391.2004
   Las G, 2011, J BIOL CHEM, V286, P42534, DOI 10.1074/jbc.M111.242412
   Liesa M, 2013, CELL METAB, V17, P491, DOI 10.1016/j.cmet.2013.03.002
   Lin JR, 2015, ARTERIOSCL THROM VAS, V35, P1413, DOI 10.1161/ATVBAHA.115.305706
   Liot G, 2009, CELL DEATH DIFFER, V16, P899, DOI 10.1038/cdd.2009.22
   Liu JH, 2013, FREE RADICAL BIO MED, V63, P485, DOI 10.1016/j.freeradbiomed.2013.05.038
   Liu RH, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0092810
   Macia E, 2006, DEV CELL, V10, P839, DOI 10.1016/j.devcel.2006.04.002
   Makino A, 2010, DIABETOLOGIA, V53, P1783, DOI 10.1007/s00125-010-1770-4
   Makino A, 2011, AM J PHYSIOL-REG I, V300, pR1296, DOI 10.1152/ajpregu.00437.2010
   Manczak M, 2012, BBA-MOL BASIS DIS, V1822, P862, DOI 10.1016/j.bbadis.2012.02.017
   McClain DA, 2002, P NATL ACAD SCI USA, V99, P10695, DOI 10.1073/pnas.152346899
   Montessuit S, 2010, CELL, V142, P889, DOI 10.1016/j.cell.2010.08.017
   Motori E, 2013, CELL METAB, V18, P844, DOI 10.1016/j.cmet.2013.11.005
   Muoio DM, 2006, ANNU REV BIOCHEM, V75, P367, DOI 10.1146/annurev.biochem.75.103004.142512
   Nair KS, 2008, DIABETES, V57, P1166, DOI 10.2337/db07-1556
   Nie Q, 2014, MOL BIOL REP, V41, P6975, DOI 10.1007/s11033-014-3584-9
   Ong SB, 2010, CIRCULATION, V121, P2012, DOI 10.1161/CIRCULATIONAHA.109.906610
   Osborne B, 2014, BBA-GEN SUBJECTS, V1840, P1295, DOI 10.1016/j.bbagen.2013.08.016
   Otera H, 2013, BBA-MOL CELL RES, V1833, P1256, DOI 10.1016/j.bbamcr.2013.02.002
   Otera H, 2010, J CELL BIOL, V191, P1141, DOI 10.1083/jcb.201007152
   Palmer CS, 2011, EMBO REP, V12, P565, DOI 10.1038/embor.2011.54
   Park YY, 2010, J CELL SCI, V123, P619, DOI 10.1242/jcs.061481
   Parra V, 2014, DIABETES, V63, P75, DOI 10.2337/db13-0340
   Petersen KF, 2003, SCIENCE, V300, P1140, DOI 10.1126/science.1082889
   Qi X, 2013, J CELL SCI, V126, P789, DOI 10.1242/jcs.114439
   Qian W, 2012, J CELL SCI, V125, P5745, DOI 10.1242/jcs.109769
   Salabei JK, 2013, REDOX BIOL, V1, P542, DOI 10.1016/j.redox.2013.10.011
   Santel A, 2003, J CELL SCI, V116, P2763, DOI 10.1242/jcs.00479
   Shenouda SM, 2011, CIRCULATION, V124, P444, DOI 10.1161/CIRCULATIONAHA.110.014506
   Smith ME, 2013, BIOCHEM J, V456, P427, DOI 10.1042/BJ20130807
   Su YC, 2013, HUM MOL GENET, V22, P4545, DOI 10.1093/hmg/ddt301
   Taguchi N, 2007, J BIOL CHEM, V282, P11521, DOI 10.1074/jbc.M607279200
   Twig G, 2008, EMBO J, V27, P433, DOI 10.1038/sj.emboj.7601963
   Wang HX, 2011, J BIOL CHEM, V286, P11649, DOI 10.1074/jbc.M110.144238
   Wang JN, 2015, BIOCHEM BIOPH RES CO, V456, P7, DOI 10.1016/j.bbrc.2014.11.010
   Wang W, 2011, CELL RES, V21, P730, DOI 10.1038/cr.2011.30
   Watanabe T, 2014, EXP CELL RES, V323, P314, DOI 10.1016/j.yexcr.2014.02.027
   Westermann B, 2010, NAT REV MOL CELL BIO, V11, P872, DOI 10.1038/nrm3013
   Westrate LM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0091911
   Yan J, 2012, J NUTR BIOCHEM, V23, P716, DOI 10.1016/j.jnutbio.2011.03.014
   Yeon JY, 2015, J REPROD DEVELOP, V61, P81, DOI 10.1262/jrd.2014-070
   Yonashiro R, 2006, EMBO J, V25, P3618, DOI 10.1038/sj.emboj.7601249
   Yu TZ, 2008, CARDIOVASC RES, V79, P341, DOI 10.1093/cvr/cvn104
   Yu TZ, 2006, P NATL ACAD SCI USA, V103, P2653, DOI 10.1073/pnas.0511154103
   Yue W, 2014, CELL RES, V24, P482, DOI 10.1038/cr.2014.20
   Zemirli N, 2014, FEBS J, V281, P3095, DOI 10.1111/febs.12846
   Zhang XM, 2013, J BIOMED SCI, V20, DOI 10.1186/1423-0127-20-45
   Zhang Y, 2013, MOL CELL ENDOCRINOL, V381, P230, DOI 10.1016/j.mce.2013.08.004
   Zhao J, 2011, EMBO J, V30, P2762, DOI 10.1038/emboj.2011.198
   Zorzano A, 2010, BBA-BIOENERGETICS, V1797, P1028, DOI 10.1016/j.bbabio.2010.02.017
   Zuo W, 2014, NEUROPHARMACOLOGY, V86, P103, DOI 10.1016/j.neuropharm.2014.07.002
NR 92
TC 26
Z9 30
U1 0
U2 8
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2015
VL 1350
BP 82
EP 94
DI 10.1111/nyas.12863
PG 13
WC Genetics & Heredity; Medicine, Research & Experimental
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Research & Experimental Medicine
GA BD5EZ
UT WOS:000361375900010
PM 26301786
DA 2025-06-11
ER

PT J
AU Champagne, CM
AF Champagne, Catherine M.
TI The Usefulness of a Mediterranean-Based Diet in Individuals With Type 2
   Diabetes
SO CURRENT DIABETES REPORTS
LA English
DT Article
ID LOW-GLYCEMIC INDEX; METABOLIC SYNDROME; WEIGHT-LOSS; PROSPECTIVE COHORT;
   RANDOMIZED-TRIAL; LOW-CARBOHYDRATE; HEART-DISEASE; GREEK ADULTS;
   ADHERENCE; MELLITUS
AB This article reviews current data available on the Mediterranean diet related to its use in a diabetic population. Based on many published reports, it is apparent that the Mediterranean diet may be used in dietary interventions for the treatment of overweight and obesity, conditions associated with the development of type 2 diabetes. In addition, obesity in type 2 diabetic persons is associated with other cardiovascular disease risk factors. The Mediterranean diet has been found to be inversely related to the metabolic syndrome, often a feature of diabetic individuals. Perhaps the most critical information placing the Mediterranean diet in a favorable position is the positive response of insulin, blood glucose, blood lipids, and other metabolic factors predicting cardiovascular disease risk and outcomes. This diet is a viable treatment option; advisors should stress not only adherence to a fairly traditional Mediterranean eating plan but also a lifestyle that includes sufficient physical activity.
C1 Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center
RP Champagne, CM (corresponding author), Louisiana State Univ Syst, Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM catherine.champagne@pbrc.edu
RI Champagne, Catherine/N-1956-2017
CR Agricultural Research Service Food Surveys Research Group, 2008, USDA FOOD NUTR DAT D, V3
   *AM DIET ASS, 2008, CHOOS YOUR FOODS EXC
   *AM HEART ASS, DIAB CARD DIS
   [Anonymous], The IDF consensus worldwide definition of the metabolic syndrome
   [Anonymous], NATL HLTH STAT REPOR
   BABIO N, 2009, NUTR METAB CARD 0126
   Basterra-Gortari FJ, 2008, DIABETOLOGIA, V51, P1933, DOI 10.1007/s00125-008-1121-x
   Brunner EJ, 2008, AM J CLIN NUTR, V87, P1414, DOI 10.1093/ajcn/87.5.1414
   Buckland G, 2008, OBES REV, V9, P582, DOI 10.1111/j.1467-789X.2008.00503.x
   Dansinger ML, 2005, JAMA-J AM MED ASSOC, V293, P43, DOI 10.1001/jama.293.1.43
   de Souza RJ, 2008, AM J CLIN NUTR, V88, P1
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   Esposito K, 2008, AM J CLIN NUTR, V88, P1179, DOI 10.1093/ajcn/88.4.1179
   Esposito Katherine, 2007, Metabolic Syndrome and Related Disorders, V5, P291, DOI 10.1089/met.2007.0018
   Ford ES, 2008, DIABETES CARE, V31, P1898, DOI 10.2337/dc08-0423
   Ford ES, 2008, DIABETES CARE, V31, P587, DOI 10.2337/dc07-1030
   Fraser A, 2008, DIABETOLOGIA, V51, P1935, DOI 10.1007/s00125-008-1119-4
   Fraser A, 2008, DIABETOLOGIA, V51, P1616, DOI 10.1007/s00125-008-1049-1
   Fung TT, 2009, CIRCULATION, V119, P1093, DOI 10.1161/CIRCULATIONAHA.108.816736
   Gardner CD, 2007, JAMA-J AM MED ASSOC, V297, P969, DOI 10.1001/jama.297.9.969
   Giugliano D, 2008, CURR OPIN LIPIDOL, V19, P63, DOI 10.1097/MOL.0b013e3282f2fa4d
   Giugliano Dario, 2008, Diabetes Care, V31, pe37, DOI 10.2337/dc07-2130
   *INT DIAB FDN, FACT SHEET DIAB CARD
   Jenkins DJA, 2008, JAMA-J AM MED ASSOC, V300, P2742, DOI 10.1001/jama.2008.808
   Laakso M, 1999, DIABETES, V48, P937, DOI 10.2337/diabetes.48.5.937
   MAGKOS F, 2009, ANN REV NUTR    0427
   Mantzoros CS, 2006, AM J CLIN NUTR, V84, P328
   MARINOU K, 2009, INT J CARDIOL   0425
   Martínez-González MA, 2008, BMJ-BRIT MED J, V336, P1348, DOI 10.1136/bmj.39561.501007.BE
   Mendez MA, 2006, J NUTR, V136, P2934, DOI 10.1093/jn/136.11.2934
   MUNOZ MA, 2008, BR J NUTR, V15, P1
   O'Keefe JH, 2008, J AM COLL CARDIOL, V51, P249, DOI 10.1016/j.jacc.2007.10.016
   Panagiotakos DB, 2005, DIABETIC MED, V22, P1581, DOI 10.1111/j.1464-5491.2005.01731.x
   Panagiotakos DB, 2004, AM HEART J, V147, P106, DOI 10.1016/S0002-8703(03)00442-3
   Panagiotakos DB, 2007, ASIA PAC J CLIN NUTR, V16, P331
   Panagiotakos DB, 2007, J AM COLL NUTR, V26, P32, DOI 10.1080/07315724.2007.10719583
   Ratner RE, 2006, DIABETES OBES METAB, V8, P419, DOI 10.1111/j.1463-1326.2006.00589.x
   Riddle MC, 2006, DIABETES-METAB RES, V22, P483, DOI 10.1002/dmrr.646
   Rosenstock Julio, 2007, Curr Opin Endocrinol Diabetes Obes, V14, P98, DOI 10.1097/MED.0b013e3280a02f65
   Sacks FM, 2009, NEW ENGL J MED, V360, P859, DOI 10.1056/NEJMoa0804748
   Salas-Salvadó J, 2008, ARCH INTERN MED, V168, P2449, DOI 10.1001/archinte.168.22.2449
   Sánchez-Villegas A, 2006, INT J OBESITY, V30, P350, DOI 10.1038/sj.ijo.0803118
   Saura-Calixto F, 2009, CRIT REV FOOD SCI, V49, P145, DOI 10.1080/10408390701764732
   Schröder H, 2004, J NUTR, V134, P3355, DOI 10.1093/jn/134.12.3355
   Seguí-Gómez M, 2006, INT J EPIDEMIOL, V35, P1417, DOI 10.1093/ije/dyl223
   Serra-Majem Lluis, 2008, Pol Arch Med Wewn, V118, P691
   Shai I, 2008, NEW ENGL J MED, V359, P229, DOI 10.1056/NEJMoa0708681
   Tortosa A, 2007, DIABETES CARE, V30, P2957, DOI 10.2337/dc07-1231
   Westman EC, 2008, NUTR METAB, V5, DOI 10.1186/1743-7075-5-36
   WILLETT WC, 1995, AM J CLIN NUTR, V61, p1402S, DOI 10.1093/ajcn/61.6.1402S
NR 50
TC 11
Z9 13
U1 0
U2 12
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1534-4827
EI 1539-0829
J9 CURR DIABETES REP
JI Curr. Diabetes Rep.
PD OCT
PY 2009
VL 9
IS 5
BP 389
EP 395
DI 10.1007/s11892-009-0060-3
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 500EI
UT WOS:000270280700009
PM 19793509
DA 2025-06-11
ER

PT J
AU Wang, J
   Ke, WX
   Bao, R
   Hu, XS
   Chen, F
AF Wang, Jing
   Ke, Weixin
   Bao, Rui
   Hu, Xiaosong
   Chen, Fang
TI Beneficial effects of ginger Zingiber officinale Roscoe on
   obesity and metabolic syndrome: a review
SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
LA English
DT Review
DE metabolic syndrome; Zingiber officinale; obesity; diabetes mellitus;
   mechanism
ID PROLIFERATOR-ACTIVATED RECEPTORS; PREVENTS ADIPOGENESIS;
   INSULIN-RESISTANCE; PLASMA-CHOLESTEROL; ETHANOLIC EXTRACT;
   GLUCOSE-UPTAKE; LIPID PROFILE; DIET; 6-GINGEROL; CONSUMPTION
AB In recent years, metabolic syndromes (MetSs), including diabetes mellitus, dyslipidemia, and cardiovascular diseases, have become a common health problem in both developed and developing countries. Accumulating data have suggested that traditional herbs might be able to provide a wide range of remedies in prevention and treatment of MetSs. Ginger (Zingiber officinale Roscoe, Zingiberaceae) has been documented to ameliorate hyperlipidemia, hyperglycemia, oxidative stress, and inflammation. These beneficial effects aremediated by transcription factors, such as peroxisome proliferator-activated receptors, adenosine monophosphate-activated protein kinase, and nuclear factor kappa B. This review focuses on recent findings regarding the beneficial effects of ginger on obesity and related complications in MetS and discusses its potential mechanisms of action. This review provides guidance for further applications of ginger for personalized nutrition and medicine.
C1 [Wang, Jing; Ke, Weixin; Bao, Rui; Hu, Xiaosong; Chen, Fang] China Agr Univ, Natl Engn Res Ctr Fruit & Vegetable Proc, Coll Food Sci & Nutr Engn, Minist Agr,Key Lab Fruit & Vegetable Proc, Beijing, Peoples R China.
   [Wang, Jing; Ke, Weixin; Bao, Rui; Hu, Xiaosong; Chen, Fang] China Agr Univ, Engn Res Ctr Fruit & Vegetable Proc, Minist Educ, Beijing, Peoples R China.
   [Wang, Jing; Hu, Xiaosong] China Agr Univ, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Coll Food Sci & Nutr Engn, Beijing, Peoples R China.
C3 Ministry of Agriculture & Rural Affairs; China Agricultural University;
   Ministry of Education - China; China Agricultural University; China
   Agricultural University
RP Chen, F (corresponding author), China Agr Univ, Coll Food Sci & Nutr Engn, 17 Qinghua East Rd, Beijing 100083, Peoples R China.
EM chenfangch@sina.com
RI Bao, Rui/MAH-8361-2025; Co, Annie/LBI-5115-2024; chen,
   fang/KVA-6644-2024; Wang, Jing/ABB-5658-2021
OI Wang, Jing/0000-0002-6394-5357
FU Beijing Municipal Science and Technology Project [D16110500540000]
FX Funding for this review was provided by the Beijing Municipal Science
   and Technology Project (Project No. D16110500540000).
CR Abdulrazaq NB, 2012, BRIT J NUTR, V108, P1194, DOI 10.1017/S0007114511006635
   Akhani SP, 2004, J PHARM PHARMACOL, V56, P101, DOI 10.1211/0022357022403
   Akinyemi AJ, 2016, PHYTOTHER RES, V30, P1156, DOI 10.1002/ptr.5621
   Akinyemi AJ, 2016, J APPL BIOMED, V14, P59, DOI 10.1016/j.jab.2015.06.001
   Akinyemi AJ, 2015, J FUNCT FOODS, V17, P792, DOI 10.1016/j.jff.2015.06.011
   Akinyemi AJ, 2014, J MED FOOD, V17, P317, DOI 10.1089/jmf.2012.0264
   Al-Amin ZM, 2006, BRIT J NUTR, V96, P660, DOI 10.1079/BJN20061849
   [Anonymous], INT J PHARM
   Arablou T, 2014, INT J FOOD SCI NUTR, V65, P515, DOI 10.3109/09637486.2014.880671
   Attari VE, 2016, EUR J NUTR, V55, P2129, DOI 10.1007/s00394-015-1027-6
   Attari VE, 2015, PHYTOTHER RES, V29, P1032, DOI 10.1002/ptr.5343
   Azimi P, 2016, BLOOD PRESSURE, V25, P133, DOI 10.3109/08037051.2015.1111020
   Bhandari U, 2005, J ETHNOPHARMACOL, V97, P227, DOI 10.1016/j.jep.2004.11.011
   Brown JD, 2007, CIRCULATION, V115, P518, DOI 10.1161/CIRCULATIONAHA.104.475673
   Chakraborty D, 2012, TOXICOL LETT, V210, P34, DOI 10.1016/j.toxlet.2012.01.002
   Chalasani N, 2012, GASTROENTEROLOGY, V142, P1592, DOI 10.1053/j.gastro.2012.04.001
   Dugasani S, 2010, J ETHNOPHARMACOL, V127, P515, DOI 10.1016/j.jep.2009.10.004
   ElRokh El-Sayed M., 2010, Inflammopharmacology, V18, P309, DOI 10.1007/s10787-010-0053-5
   Fuhrman B, 2000, J NUTR, V130, P1124
   Gao H., 2011, EVID-BASED COMPL ALT
   Ghasemzadeh A., 2012, Journal of Medicinal Plants Research, V6, P790
   Gross B, 2017, NAT REV ENDOCRINOL, V13, P36, DOI 10.1038/nrendo.2016.135
   Han YA, 2013, PHYTOTHER RES, V27, P1200, DOI 10.1002/ptr.4847
   Hasan IH, 2016, PHARMACOLOGY, V97, P1, DOI 10.1159/000441229
   Huang THW, 2005, BASIC CLIN PHARMACOL, V96, P3, DOI 10.1111/j.1742-7843.2005.pto960102.x
   Iizuka K, 2006, AM J PHYSIOL-ENDOC M, V291, pE358, DOI 10.1152/ajpendo.00027.2006
   Imani H, 2015, NUTRITION, V31, P703, DOI 10.1016/j.nut.2014.11.020
   Isa Y, 2008, BIOCHEM BIOPH RES CO, V373, P429, DOI 10.1016/j.bbrc.2008.06.046
   Jafri SA, 2011, PAK VET J, V31, P160
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kazeem MI, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/935486
   Khandouzi N, 2015, IRAN J PHARM RES, V14, P131
   Kota N, 2012, FOOD CHEM, V135, P2954, DOI 10.1016/j.foodchem.2012.06.116
   Lai C.S., 2016, MOL NUTR FOOD RES
   Lai YS, 2016, J AGR FOOD CHEM, V64, P2062, DOI 10.1021/acs.jafc.5b06159
   Lee JO, 2015, J CELL BIOCHEM, V116, P1401, DOI 10.1002/jcb.25100
   Lei L, 2014, J AGR FOOD CHEM, V62, P10515, DOI 10.1021/jf5043344
   Li CB, 2015, TOXICOL IN VITRO, V30, P394, DOI 10.1016/j.tiv.2015.09.023
   Li XH, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/146142
   Li XH, 2012, BASIC CLIN PHARMACOL, V110, P238, DOI 10.1111/j.1742-7843.2011.00791.x
   Li YM, 2014, BASIC CLIN PHARMACOL, V115, P209, DOI 10.1111/bcpt.12196
   Li YM, 2013, J PHARM PHARM SCI, V16, P304, DOI 10.18433/J34G7P
   Mahluji S, 2013, INT J FOOD SCI NUTR, V64, P682, DOI 10.3109/09637486.2013.775223
   Mahluji S, 2013, ADV PHARM BULL, V3, P273, DOI 10.5681/apb.2013.044
   Mansour MS, 2012, METABOLISM, V61, P1347, DOI 10.1016/j.metabol.2012.03.016
   Matsuda A, 2009, LIFE SCI, V84, P903, DOI 10.1016/j.lfs.2009.04.004
   Misawa K, 2015, J NUTR BIOCHEM, V26, P1058, DOI 10.1016/j.jnutbio.2015.04.014
   Mozaffari-Khosravi H, 2014, COMPLEMENT THER MED, V22, P9, DOI 10.1016/j.ctim.2013.12.017
   Naidu PB, 2016, MOL CELL ENDOCRINOL, V419, P139, DOI 10.1016/j.mce.2015.10.007
   Nammi S, 2010, BASIC CLIN PHARMACOL, V106, P389, DOI 10.1111/j.1742-7843.2009.00497.x
   Nammi S, 2009, BASIC CLIN PHARMACOL, V104, P366, DOI 10.1111/j.1742-7843.2008.00362.x
   Noipha K, 2010, Diabetes Res Clin Pract, V89, pe22, DOI 10.1016/j.diabres.2010.04.021
   Oh SY, 2012, BIOTECHNOL BIOPROC E, V17, P168, DOI 10.1007/s12257-011-0433-8
   Rahimlou M, 2016, HEPAT MON, V16, DOI 10.5812/hepatmon.34897
   Rani MP, 2012, J SCI FOOD AGR, V92, P1948, DOI 10.1002/jsfa.5567
   Rani MP, 2011, INT J FOOD SCI NUTR, V62, P106, DOI 10.3109/09637486.2010.515565
   Roufogalis, 2014, NEW J SCI, V2014, DOI DOI 10.1155/2014/674684
   Sani NFA, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/160695
   Saravanan G, 2014, J SCI FOOD AGR, V94, P2972, DOI 10.1002/jsfa.6642
   Seidell JC, 2015, ANN NUTR METAB, V66, P7, DOI 10.1159/000375143
   Shanmugam KR, 2011, FOOD CHEM, V124, P1436, DOI 10.1016/j.foodchem.2010.07.104
   Son MJ, 2015, CYTOTECHNOLOGY, V67, P641, DOI 10.1007/s10616-014-9730-3
   Stump M, 2015, CURR HYPERTENS REP, V17, DOI 10.1007/s11906-015-0601-x
   Suk S, 2016, J FOOD BIOCHEM, V40, P84, DOI 10.1111/jfbc.12191
   Sun NN, 2016, MOLECULES, V21, DOI 10.3390/molecules21101351
   Tzeng TF, 2015, PHYTOMEDICINE, V22, P452, DOI 10.1016/j.phymed.2015.01.015
   Tzeng TF, 2015, NUTRIENTS, V7, P999, DOI 10.3390/nu7020999
   Tzeng TF, 2013, PHYTOMEDICINE, V20, P481, DOI 10.1016/j.phymed.2012.12.006
   Wang JW, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/590376
   Wang YZ, 2013, J NANOMATER, V2013, DOI 10.1155/2013/169405
   White B, 2007, AM FAM PHYSICIAN, V75, P1689
   Zick SM, 2008, CANCER EPIDEM BIOMAR, V17, P1930, DOI 10.1158/1055-9965.EPI-07-2934
NR 72
TC 108
Z9 120
U1 1
U2 67
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0077-8923
EI 1749-6632
J9 ANN NY ACAD SCI
JI Ann. N.Y. Acad. Sci.
PD JUN
PY 2017
VL 1398
IS 1
SI SI
BP 83
EP 98
DI 10.1111/nyas.13375
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FA5BM
UT WOS:000405457600008
PM 28505392
DA 2025-06-11
ER

PT J
AU Noonan, EM
   Farrell, TW
AF Noonan, Erika M.
   Farrell, Timothy W.
TI Primary Care of the Prostate Cancer Survivor
SO AMERICAN FAMILY PHYSICIAN
LA English
DT Article
ID ANDROGEN-DEPRIVATION THERAPY; RADICAL PROSTATECTOMY; ERECTILE FUNCTION;
   INCREASED RISK; RADIATION; DIAGNOSIS; ANXIETY; IMPACT
AB This summary of the American Cancer Society Prostate Cancer Survivorship Care Guidelines targets primary care physicians who coordinate care of prostate cancer survivors with subspecialists. Prostate cancer survivors should undergo prostate-specific antigen screening every six to 12 months and digital rectal examination annually. Surveillance of patients who choose watchful waiting for their prostate cancer should be conducted by a subspecialist. Any hematuria or rectal bleeding must be thoroughly evaluated. Prostate cancer survivors should be screened regularly for urinary incontinence and sexual dysfunction. Patients with predominant urge incontinence symptoms, which can occur after surgical and radiation treatments, may benefit from an anticholinergic agent. If there is difficulty with bladder emptying, a trial of an alpha blocker may be considered. A phosphodiesterase type 5 inhibitor can effectively treat sexual dysfunction following treatment for prostate cancer. Osteoporosis screening should occur before initiation of androgen deprivation therapy, and patients treated with androgen deprivation therapy should be monitored for anemia, metabolic syndrome, and vasomotor symptoms. Healthy lifestyle choices should be encouraged, including weight management, regular physical activity, proper nutrition, and smoking cessation. Primary care physicians should be vigilant for psychosocial distress, including depression, among prostate cancer survivors, as well as the potential impact of this distress on patients' family members and partners. Copyright (C) 2016 American Academy of Family Physicians.
C1 [Noonan, Erika M.] Intermt Healthcare, Provo, UT USA.
   [Farrell, Timothy W.] Univ Utah, Sch Med, Div Geriatr, Med, Salt Lake City, UT USA.
   [Farrell, Timothy W.] Univ Utah, Sch Med, Dept Family & Prevent Med, Family Med, Salt Lake City, UT USA.
   [Farrell, Timothy W.] VA Salt Lake City Geriatr Res Educ & Clin Ctr, Salt Lake City, UT USA.
C3 Intermountain Healthcare; Intermountain Medical Center; Utah System of
   Higher Education; University of Utah; Utah System of Higher Education;
   University of Utah; Geriatric Research Education & Clinical Center; US
   Department of Veterans Affairs
RP Noonan, EM (corresponding author), 3200 North Canyon Rd,Ste C, Provo, UT 84604 USA.
CR Alemozaffar M, 2011, JAMA-J AM MED ASSOC, V306, P1205, DOI 10.1001/jama.2011.1333
   Anguiano L, 2012, CANCER NURS, V35, pE14, DOI 10.1097/NCC.0b013e31822fc76c
   [Anonymous], 2015, NCCN clinical practice guidelines in oncology: Prostate cancer
   [Anonymous], CA CANC J CLIN
   Baxter NN, 2005, GASTROENTEROLOGY, V128, P819, DOI 10.1053/j.gastro.2004.12.038
   Bober SL, 2009, CANCER, V115, P4409, DOI 10.1002/cncr.24590
   Centers for Disease Control and Prevention, 2011, HLTH REL QUAL LIF
   DeSantis CE, 2014, CA-CANCER J CLIN, V64, P252, DOI 10.3322/caac.21235
   Do NL, 2011, GASTROENT RES PRACT, V2011, DOI 10.1155/2011/917941
   Grossmann M, 2012, ASIAN J ANDROL, V14, P187, DOI 10.1038/aja.2011.102
   Hanchanale V, 2013, EUR UROL SUPPL, V12, P18, DOI 10.1016/j.eursup.2013.03.004
   Hewitt M., 2005, CANC PATIENT CANC SU
   Jayadevappa R, 2012, PSYCHO-ONCOLOGY, V21, P1338, DOI 10.1002/pon.2032
   Korfage IJ, 2006, BRIT J CANCER, V94, P1093, DOI 10.1038/sj.bjc.6603057
   Latini DM, 2007, J UROLOGY, V178, P826, DOI 10.1016/j.juro.2007.05.039
   Miles CL, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005540.pub2
   Moreira DM, 2014, CANCER-AM CANCER SOC, V120, P197, DOI 10.1002/cncr.28423
   Morgans AK, 2013, CANCER-AM CANCER SOC, V119, P863, DOI 10.1002/cncr.27830
   Murray L, 2014, RADIOTHER ONCOL, V110, P213, DOI 10.1016/j.radonc.2013.12.012
   Reeve BB, 2012, CANCER-AM CANCER SOC, V118, P5679, DOI 10.1002/cncr.27578
   Resendes LA, 2006, CANCER INVEST, V24, P192, DOI 10.1080/07357900500524652
   Resnick MJ, 2013, NEW ENGL J MED, V368, P436, DOI 10.1056/NEJMoa1209978
   Sandhu JS, 2014, UROL PRACT, V1, P194
   Saylor PJ, 2013, J UROLOGY, V189, pS34, DOI 10.1016/j.juro.2012.11.017
   Skolarus TA, 2014, CA-CANCER J CLIN, V64, P226, DOI 10.3322/caac.21234
   Taylor LG, 2009, CANCER-AM CANCER SOC, V115, P2388, DOI 10.1002/cncr.24283
   Walker LM, 2013, CLIN GENITOURIN CANC, V11, P375, DOI 10.1016/j.clgc.2013.05.004
   Zenger Markus, 2010, Psychosoc Med, V7, pDoc02, DOI 10.3205/psm000064
NR 28
TC 7
Z9 8
U1 0
U2 7
PU AMER ACAD FAMILY PHYSICIANS
PI KANSAS CITY
PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA
SN 0002-838X
EI 1532-0650
J9 AM FAM PHYSICIAN
JI Am. Fam. Physician
PD MAY 1
PY 2016
VL 93
IS 9
BP 764
EP 770
PG 7
WC Primary Health Care; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DL1BW
UT WOS:000375368000008
PM 27175954
DA 2025-06-11
ER

PT J
AU Agarwal, A
   Rana, M
   Qiu, E
   AlBunni, H
   Bui, AD
   Henkel, R
AF Agarwal, Ashok
   Rana, Mohit
   Qiu, Emily
   AlBunni, Hashem
   Bui, Albert D.
   Henkel, Ralf
TI Role of oxidative stress, infection and inflammation in male infertility
SO ANDROLOGIA
LA English
DT Review
DE causes of oxidative stress; male genital tract infections; oxidative
   stress; sexually transmitted diseases
ID HEPATITIS-C-VIRUS; CHLAMYDIA-TRACHOMATIS INFECTIONS; PLASMA-MEMBRANE
   INTEGRITY; IN-VITRO FERTILIZATION; UREAPLASMA-UREALYTICUM;
   LIPID-PEROXIDATION; SEMINAL PLASMA; SEMEN QUALITY; CIGARETTE-SMOKING;
   ESCHERICHIA-COLI
AB Oxidative stress (OS), defined as an overabundance of reactive oxygen species (ROS) or a deficiency of antioxidants, has been linked to sperm damage and male infertility. There are many sources of OS and inflammation including varicocele, tobacco usage, alcohol, obesity/metabolic syndrome, leukocytospermia, sexually transmitted disease (i.e., Neisseria gonorrhoeae, Chlamydia trachomatis, Treponema pallidum), bacterial prostatitis, microorganism mutations leading to more OS, and viral infections (i.e., human immunodeficiency virus, hepatitis). This review is focusing on infection and inflammation-mediated OS, the inflammatory markers underlying pathology, clinical significance in male infertility, and a brief description of the recommended treatment modalities.
C1 [Agarwal, Ashok; Rana, Mohit; Qiu, Emily; AlBunni, Hashem; Bui, Albert D.; Henkel, Ralf] Cleveland Clin, Amer Ctr Reprod Med, Cleveland, OH 44195 USA.
   [Bui, Albert D.] Ohio Univ, Heritage Coll Osteopath Med, Athens, OH 45701 USA.
   [Henkel, Ralf] Univ Western Cape, Dept Med Biosci, Bellville, South Africa.
C3 Cleveland Clinic Foundation; University System of Ohio; Ohio University;
   University of the Western Cape
RP Agarwal, A (corresponding author), Cleveland Clin, Amer Ctr Reprod Med, Cleveland, OH 44195 USA.
EM agarwaa@ccf.org
OI Henkel, Ralf/0000-0003-1128-2982
CR Abusarah EA, 2013, DIAGN MICR INFEC DIS, V77, P283, DOI 10.1016/j.diagmicrobio.2013.05.018
   Agarwal A, 2003, FERTIL STERIL, V79, P829, DOI 10.1016/S0015-0282(02)04948-8
   Agarwal A, 2017, INDIAN J UROL, V33, P199, DOI 10.4103/iju.IJU_9_17
   Agarwal A, 2009, UROLOGY, V73, P461, DOI 10.1016/j.urology.2008.07.053
   Ahmad G., 2017, Male Infertility, P167
   AITKEN RJ, 1995, HUM REPROD, V10, P1736, DOI 10.1093/oxfordjournals.humrep.a136165
   AITKEN RJ, 1993, J REPROD FERTIL, V98, P257
   AITKEN RJ, 1987, J REPROD FERTIL, V81, P459
   Aitken RJ, 2017, MOL REPROD DEV, V84, P1039, DOI 10.1002/mrd.22871
   Aitken RJ, 2016, REPROD FERT DEVELOP, V28, P1, DOI 10.1071/RD15325
   Alexopoulou L, 2002, NAT MED, V8, P878, DOI 10.1038/nm732
   Allen JD, 2009, BRIT J PHARMACOL, V158, P1653, DOI 10.1111/j.1476-5381.2009.00447.x
   Alshahrani S, 2013, J REPROD IMMUNOL, V100, P30, DOI 10.1016/j.jri.2013.05.004
   Anderson K, 2010, AUST NZ J OBSTET GYN, V50, P8, DOI 10.1111/j.1479-828X.2009.01119.x
   Andrade-Rocha FT, 2003, UROL INT, V71, P377, DOI 10.1159/000074089
   [Anonymous], WHO CDC S CONG SYPH
   AREND WP, 1994, IMMUNOPHARMACOLOGY J, P129
   Azenabor Alfred, 2015, J Reprod Infertil, V16, P123
   Aziz N, 2004, FERTIL STERIL, V82, P621, DOI 10.1016/j.fertnstert.2004.02.112
   Bachir BG, 2014, UROL CLIN N AM, V41, P67, DOI 10.1016/j.ucl.2013.08.008
   Benoff S, 2005, FERTIL STERIL, V83, P622, DOI 10.1016/j.fertnstert.2004.07.976
   Benova L, 2014, CLIN INFECT DIS, V59, P765, DOI 10.1093/cid/ciu447
   Bhasin S, 2010, J CLIN ENDOCR METAB, V95, P2536, DOI 10.1210/jc.2009-2354
   Boguen R, 2015, FERTIL STERIL, V103, P1155, DOI 10.1016/j.fertnstert.2015.01.044
   Brightbill HD, 1999, SCIENCE, V285, P732, DOI 10.1126/science.285.5428.732
   Cabler S, 2010, ASIAN J ANDROL, V12, P480, DOI 10.1038/aja.2010.38
   Camejo MI, 2001, ARCH ANDROLOGY, V47, P97, DOI 10.1080/014850101316901280
   Cates W, 1999, SEX TRANSM DIS, V26, pS2, DOI 10.1097/00007435-199904001-00002
   Château A, 2016, CELL MICROBIOL, V18, P546, DOI 10.1111/cmi.12529
   Cicero TJ, 2014, JAMA PSYCHIAT, V71, P821, DOI 10.1001/jamapsychiatry.2014.366
   CLOSE CE, 1990, J UROLOGY, V144, P900, DOI 10.1016/S0022-5347(17)39618-0
   Colagar A Hosseinzadeh, 2007, Pak J Biol Sci, V10, P3870, DOI 10.3923/pjbs.2007.3870.3874
   COMHAIRE F, 1994, AM J REPROD IMMUNOL, V31, P99, DOI 10.1111/j.1600-0897.1994.tb00853.x
   Comhaire FH, 1999, HUM REPROD UPDATE, V5, P393, DOI 10.1093/humupd/5.5.393
   Costello LC, 2004, PROSTATE CANCER P D, V7, P111, DOI 10.1038/sj.pcan.4500712
   Cross NL, 1998, BIOL REPROD, V59, P7, DOI 10.1095/biolreprod59.1.7
   Cruz AR, 2012, PLOS NEGLECT TROP D, V6, DOI 10.1371/journal.pntd.0001717
   DAHLBERG B, 1976, Urology, V8, P563, DOI 10.1016/0090-4295(76)90518-5
   Das SK, 2007, LIFE SCI, V81, P177, DOI 10.1016/j.lfs.2007.05.005
   DAVIS BK, 1981, P NATL ACAD SCI-BIOL, V78, P7560, DOI 10.1073/pnas.78.12.7560
   de Lamirande E, 2008, BBA-PROTEINS PROTEOM, V1784, P106, DOI 10.1016/j.bbapap.2007.08.024
   DELAMIRANDE E, 1993, INT J ANDROL, V16, P21
   den Hartog JE, 2009, DRUG TODAY, V45, P75
   Diemer T, 2003, ANDROLOGIA, V35, P100, DOI 10.1046/j.1439-0272.2003.00523.x
   Diemer T, 1996, INT J ANDROL, V19, P271, DOI 10.1111/j.1365-2605.1996.tb00475.x
   Dobrakowski M, 2017, ANDROLOGIA, V49, DOI 10.1111/and.12783
   Domes T, 2012, FERTIL STERIL, V97, P1050, DOI 10.1016/j.fertnstert.2012.01.124
   Duru NK, 2000, FERTIL STERIL, V74, P1200
   Dwyer DJ, 2014, P NATL ACAD SCI USA, V111, pE2100, DOI 10.1073/pnas.1401876111
   Dwyer DJ, 2009, CURR OPIN MICROBIOL, V12, P482, DOI 10.1016/j.mib.2009.06.018
   Edlund C, 2000, J ANTIMICROB CHEMOTH, V46, P41, DOI 10.1093/jac/46.suppl_1.41
   Esposito K, 2006, J ENDOCRINOL INVEST, V29, P791, DOI 10.1007/BF03347372
   Frapsauce C, 2015, HUM REPROD, V30, P1797, DOI 10.1093/humrep/dev141
   Frederiks WM, 2001, HISTOCHEM J, V33, P345, DOI 10.1023/A:1012427224822
   French DB, 2008, CURR OPIN OBSTET GYN, V20, P269, DOI 10.1097/GCO.0b013e3282fcc00c
   Frey KA, 2008, AM J OBSTET GYNECOL, V199, pS389, DOI 10.1016/j.ajog.2008.10.024
   GALDIERO F, 1988, INFECTION, V16, P349, DOI 10.1007/BF01644545
   Gallegos G, 2008, FERTIL STERIL, V90, P328, DOI 10.1016/j.fertnstert.2007.06.035
   Garolla A, 2013, J REPROD IMMUNOL, V100, P20, DOI 10.1016/j.jri.2013.03.004
   GAVELLA M, 1992, ARCH ANDROLOGY, V28, P135, DOI 10.3109/01485019208987691
   Gdoura R, 2008, J ANDROL, V29, P198, DOI 10.2164/jandrol.107.003566
   Gimenes F, 2014, NAT REV UROL, V11, P672, DOI 10.1038/nrurol.2014.285
   Gomez E, 1996, J ANDROL, V17, P276
   GRIVEAU JF, 1994, INT J ANDROL, V17, P300, DOI 10.1111/j.1365-2605.1994.tb01260.x
   Ha HK, 2011, ASIAN J ANDROL, V13, P470, DOI 10.1038/aja.2010.94
   Hagan S, 2015, ANDROLOGY-US, V3, P848, DOI 10.1111/andr.12074
   Hampl R, 2012, Ceska Gynekol, V77, P241
   Harlev A, 2015, WORLD J MENS HEALTH, V33, P143, DOI 10.5534/wjmh.2015.33.3.143
   HECHT D, 1992, BIOCHEM BIOPH RES CO, V188, P773, DOI 10.1016/0006-291X(92)91123-8
   Henkel R., 2012, MALE INFERTILITY, P261
   Henkel R, 2007, ASIAN J ANDROL, V9, P299, DOI 10.1111/j.1745-7262.2007.00270.x
   Hofny ERM, 2011, FERTIL STERIL, V95, P2557, DOI 10.1016/j.fertnstert.2011.05.014
   Idahl A, 2010, AM J OBSTET GYNECOL, V202, DOI 10.1016/j.ajog.2009.07.042
   Bini EI, 2015, TUBERCULOSIS, V95, P701, DOI 10.1016/j.tube.2015.06.002
   KAMPMEIER RH, 1964, MED CLIN N AM, V48, P667, DOI 10.1016/S0025-7125(16)33449-6
   Kang XJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033471
   Karimi O, 2009, DRUG TODAY, V45, P67
   Kashou AH, 2012, OXID STRESS APPL BAS, P571, DOI 10.1007/978-1-61779-776-7_26
   Kehl S, 2011, ARCH GYNECOL OBSTET, V284, P229, DOI 10.1007/s00404-011-1898-6
   Klonoff-Cohen H, 2003, FERTIL STERIL, V79, P330, DOI 10.1016/S0015-0282(02)04582-X
   Koçak I, 2002, UROL RES, V30, P263, DOI 10.1007/s00240-002-0269-y
   Konukoglu D, 2006, ARCH MED RES, V37, P602, DOI 10.1016/j.arcmed.2005.12.002
   Krupp Karl, 2015, Indian J Sex Transm Dis AIDS, V36, P3, DOI 10.4103/0253-7184.156680
   La Maestra S, 2015, INT J HYG ENVIR HEAL, V218, P117, DOI 10.1016/j.ijheh.2014.08.006
   La Vignera S, 2012, EUR J INTERN MED, V23, pE19, DOI 10.1016/j.ejim.2011.08.011
   Lavranos G, 2012, REPROD TOXICOL, V34, P298, DOI 10.1016/j.reprotox.2012.06.007
   Leisegang K, 2018, REPROD BIOL ENDOCRIN, V16, DOI 10.1186/s12958-018-0341-2
   Leisegang K, 2016, AM J REPROD IMMUNOL, V76, P155, DOI 10.1111/aji.12529
   Lien E, 1999, J BIOL CHEM, V274, P33419, DOI 10.1074/jbc.274.47.33419
   Lipsky BA, 2010, CLIN INFECT DIS, V50, P1641, DOI 10.1086/652861
   Lorusso F, 2010, ANDROLOGIA, V42, P121, DOI 10.1111/j.1439-0272.2009.00970.x
   Machida K, 2006, J VIROL, V80, P7199, DOI 10.1128/JVI.00321-06
   MacLeod J, 1943, AM J PHYSIOL, V138, P0512, DOI 10.1152/ajplegacy.1943.138.3.512
   Magri V, 2007, INT J ANTIMICROB AG, V29, P549, DOI 10.1016/j.ijantimicag.2006.09.027
   Martínez P, 2007, ASIAN J ANDROL, V9, P102, DOI 10.1111/j.1745-7262.2007.00238.x
   Martínez-Prado E, 2010, AM J REPROD IMMUNOL, V63, P233, DOI 10.1111/j.1600-0897.2009.00786.x
   Mavrogiorgos N, 2014, INNATE IMMUN-LONDON, V20, P377, DOI 10.1177/1753425913493453
   Meldrum DR, 2016, FERTIL STERIL, V105, P548, DOI 10.1016/j.fertnstert.2016.01.013
   Moretti E, 2009, J ASSIST REPROD GEN, V26, P47, DOI 10.1007/s10815-008-9283-5
   Morrison CD, 2015, BEST PRACT RES CL OB, V29, P507, DOI 10.1016/j.bpobgyn.2014.10.006
   Mosser DM, 2008, NAT REV IMMUNOL, V8, P958, DOI 10.1038/nri2448
   Muthusami KR, 2005, FERTIL STERIL, V84, P919, DOI 10.1016/j.fertnstert.2005.04.025
   Nandipati KC, 2005, ANDROLOGIA, V37, P131, DOI 10.1111/j.1439-0272.2005.00668.x
   NAZ RK, 1994, J ANDROL, V15, P220
   Nelson LR, 2001, J AM ACAD DERMATOL, V45, pS116, DOI 10.1067/mjd.2001.117432
   Newman L, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0143304
   Newton K, 2012, CSH PERSPECT BIOL, V4, DOI 10.1101/cshperspect.a006049
   Nicolau P, 2014, GYNECOL ENDOCRINOL, V30, P759, DOI 10.3109/09513590.2014.938623
   Núñez-Calonge R, 1998, HUM REPROD, V13, P2756, DOI 10.1093/humrep/13.10.2756
   Oliphant CM, 2002, AM FAM PHYSICIAN, V65, P455
   Ozbek E, 2000, EUR UROL, V37, P172, DOI 10.1159/000020135
   Ozgur Kemal, 2005, Archives of Gynecology and Obstetrics, V271, P109, DOI 10.1007/s00404-003-0572-z
   Palmer Nicole O, 2012, Spermatogenesis, V2, P253
   Pasqualotto FF, 2008, FERTIL STERIL, V89, P602, DOI 10.1016/j.fertnstert.2007.03.057
   Patti ME, 2003, P NATL ACAD SCI USA, V100, P8466, DOI 10.1073/pnas.1032913100
   Pavili L, 2010, FERTIL STERIL, V94, P2151, DOI 10.1016/j.fertnstert.2009.12.080
   PLANTE M, 1994, FERTIL STERIL, V62, P387
   Qian L, 2016, AM J REPROD IMMUNOL, V76, P183, DOI 10.1111/aji.12537
   RAJASEKARAN M, 1995, FERTIL STERIL, V64, P166
   RAMIREZ JP, 1992, ANDROLOGIA, V24, P141
   Reichart M, 2000, BIOL REPROD, V63, P1041, DOI 10.1095/biolreprod63.4.1041
   Richthoff J, 2008, INT J ANDROL, V31, P31, DOI 10.1111/j.1365-2605.2007.00752.x
   Rietmeijer CA, 2002, SEX TRANSM DIS, V29, P65, DOI 10.1097/00007435-200202000-00001
   Romeo C, 2003, HUM REPROD, V18, P26, DOI 10.1093/humrep/deg004
   Rubes J, 1998, FERTIL STERIL, V70, P715, DOI 10.1016/S0015-0282(98)00261-1
   Saalu L C, 2010, Pak J Biol Sci, V13, P413
   Sabeti P, 2016, INT J REPROD BIOMED, V14, P231
   Sacks-Davis R, 2015, J R SOC INTERFACE, V12, DOI 10.1098/rsif.2014.1197
   Said TM, 2005, FERTIL STERIL, V84, P649, DOI 10.1016/j.fertnstert.2005.03.052
   Saleh RA, 2002, FERTIL STERIL, V78, P1215, DOI 10.1016/S0015-0282(02)04237-1
   Sandoval JS, 2013, MIDDLE EAST FERTIL S, V18, P129, DOI 10.1016/j.mefs.2013.02.004
   Sanocka D, 1996, J ANDROL, V17, P449
   Sanocka D, 2003, J ANDROL, V24, P448
   Sanocka-Maciejewska D, 2005, J REPROD IMMUNOL, V67, P51, DOI 10.1016/j.jri.2005.06.003
   Scares SR, 2008, CURR OPIN OBSTET GYN, V20, P281, DOI 10.1097/GCO.0b013e3282fc9c1e
   Schuppe HC, 2008, ANDROLOGIA, V40, P84, DOI 10.1111/j.1439-0272.2008.00837.x
   Sellati TJ, 1998, J IMMUNOL, V160, P5455
   Shiraishi K, 2005, HUM REPROD, V20, P2608, DOI 10.1093/humrep/dei063
   SIEGEL D, 1990, CANCER RES, V50, P7293
   Signorelli J, 2012, CELL TISSUE RES, V349, P765, DOI 10.1007/s00441-012-1370-3
   Singer M, 2016, PATHOG DIS, V74, DOI 10.1093/femspd/ftv126
   Sultana T, 2000, ENDOCRINOLOGY, V141, P4413, DOI 10.1210/en.141.12.4413
   Tiganis T, 2011, TRENDS PHARMACOL SCI, V32, P82, DOI 10.1016/j.tips.2010.11.006
   Trayhurn P, 2013, PHYSIOL REV, V93, P1, DOI 10.1152/physrev.00017.2012
   Tremellen K, 2008, HUM REPROD UPDATE, V14, P243, DOI 10.1093/humupd/dmn004
   VanVoorhis WC, 1996, INFECT IMMUN, V64, P1048, DOI 10.1128/IAI.64.3.1048-1050.1996
   Vatansever F, 2013, FEMS MICROBIOL REV, V37, P955, DOI 10.1111/1574-6976.12026
   Velando A, 2008, BIOESSAYS, V30, P1212, DOI 10.1002/bies.20838
   Vicari E, 2006, Minerva Med, V97, P65
   Villegas J, 2003, ANDROLOGIA, V35, P227, DOI 10.1046/j.1439-0272.2003.00564.x
   Vine MF, 1996, BRIT MED J, V312, P506, DOI 10.1136/bmj.312.7029.506
   VISCONTI PE, 1995, DEVELOPMENT, V121, P1129
   Wang D, 2014, J MED VIROL, V86, P1467, DOI 10.1002/jmv.23991
   Weidner W, 2002, EUR UROL, V42, P313, DOI 10.1016/S0302-2838(02)00367-6
   Wikström A, 2006, SEX TRANSM INFECT, V82, P276, DOI 10.1136/sti.2005.018598
   Will MA, 2011, FERTIL STERIL, V95, P841, DOI 10.1016/j.fertnstert.2011.01.002
   WOLFF H, 1995, FERTIL STERIL, V63, P1143
   Wooten RM, 2002, J IMMUNOL, V168, P348, DOI 10.4049/jimmunol.168.1.348
   YAMAUCHITAKIHARA K, 1995, CIRCULATION, V91, P1520, DOI 10.1161/01.CIR.91.5.1520
   Yang JH, 2017, CURR OPIN MICROBIOL, V39, P73, DOI 10.1016/j.mib.2017.09.002
   Zeighami H, 2009, INT J STD AIDS, V20, P387, DOI 10.1258/ijsa.2008.008334
   Zeinali M, 2017, ANDROLOGIA, V49, DOI 10.1111/and.12685
   Zhang ZH, 2013, IRAN J REPROD MED, V11, P589
   Zhou YH, 2018, J MICROBIOL IMMUNOL, V51, P778, DOI 10.1016/j.jmii.2016.09.004
   Zinzendorf N.Y., 2008, J. Reprod. Contracep, V19, P65, DOI [10.1016/S1001-7844(08)60008-5, DOI 10.1016/S1001-7844(08)60008-5]
NR 165
TC 201
Z9 206
U1 0
U2 32
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-4569
EI 1439-0272
J9 ANDROLOGIA
JI Andrologia
PD DEC
PY 2018
VL 50
IS 11
SI SI
AR e13126
DI 10.1111/and.13126
PG 13
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HE9SW
UT WOS:000453795800006
PM 30569652
DA 2025-06-11
ER

PT J
AU Izumida, T
   Nakamura, Y
   Sato, Y
   Ishikawa, S
AF Izumida, Toshihide
   Nakamura, Yosikazu
   Sato, Yukihiro
   Ishikawa, Shizukiyo
TI The Association Between Sleeping Pill Use and Metabolic Syndrome in an
   Apparently Healthy Population in Japan: JMS-II Cohort Study
SO JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE sleeping pills; metabolic syndrome; cardiovascular disease; epidemiology
ID QUALITY INDEX; DURATION; BENZODIAZEPINES; ZOLPIDEM; INSOMNIA; RISK;
   RESTRICTION; DEPRESSION; QUESTIONS; SYMPTOMS
AB Background: Sleeping pills are widely used for sleep disorders and insomnia. This population-based study aimed to evaluate the association between the use of sleeping pills and metabolic syndrome (MetS) and metabolic components in an apparently healthy Japanese cohort.
   Methods: We examined baseline cross-sectional data from the JMS-II Cohort Study. The criteria for MetS and its components were based on The National Cholesterol Education Program Adult Treatment Panel III. Sleep habits including the sleep duration of the subjects and the frequency of sleeping pill use were obtained using The Pittsburgh Sleep Quality Index questionnaire. For different sleep durations, the association between sleeping pill use and MetS was assessed. Odds ratios (ORs) and their 95% confidence intervals (CIs) were estimated using multiple logistic regression models to quantify this association.
   Results: Our study included 6,153 individuals (mean age, 63.8 [standard deviation 11.2] years), and 3,348 (54.4%) among them were women. The association between sleep duration and MetS was an inverted J-shaped curve among sleeping pill users and a J-shaped curve among non-users. After adjustment for various confounders, less than 6 h of sleep among sleeping pill users was associated with increased rates of MetS (<6 h, OR 3.08; 95% CI, 1.29-7.34]). The frequency of sleeping pill use in individuals with short sleep duration showed a positive association with the prevalence of MetS and its components.
   Conclusions: Sleeping pill users with a short sleep duration had a 3-fold higher chance of having MetS than non-users with a short sleep duration.
C1 [Izumida, Toshihide] Kanawaza Med Univ Himi Municipal Hosp, Div Community Med, Himi, Toyama, Japan.
   [Nakamura, Yosikazu; Ishikawa, Shizukiyo] Jichi Med Univ, Ctr Community Med, Div Publ Hlth, 3311-1 Yakushiji, Shimotsuke, Tochigi 3290498, Japan.
   [Sato, Yukihiro] Kamiichi Gen Hosp, Internal Med, Toyama, Japan.
C3 Jichi Medical University
RP Ishikawa, S (corresponding author), Jichi Med Univ, Ctr Community Med, Div Publ Hlth, 3311-1 Yakushiji, Shimotsuke, Tochigi 3290498, Japan.
EM i-shizu@jichi.ac.jp
FU MEXT-Supported Program for the Strategic Research Foundation at Private
   Universities [S0901032]; Japanese Society for the Promotion of Science
   KAKENHI [16K09141]; Ministry of Health, Labour, and Welfare; Health and
   Labor Sciences and Japan Comprehensive Research on Cardiovascular and
   Lifestyle-Related Diseases [H26-Junkankitou- [Seisaku] -Ippan-001,
   H29-Junkankitou-Ippan-003]; IRB [G09-39 [G17-64]]; Jichi Medical
   University Alumni Association Project Grant [2020 [5-3]]; Grants-in-Aid
   for Scientific Research [16K09141] Funding Source: KAKEN
FX Financial support: This research was supported by the MEXT-Supported
   Program for the Strategic Research Foundation at Private Universities
   (S0901032) ; a Japanese Society for the Promotion of Science KAKENHI
   grant (No. 16K09141) ; a Grant-In-Aid from the Ministry of Health,
   Labour, and Welfare; Health and Labor Sciences and Japan Comprehensive
   Research on Cardiovascular and Lifestyle-Related Diseases grants
   (H26-Junkankitou- [Seisaku] -Ippan-001 and H29-Junkankitou-Ippan-003;
   IRB No. G09-39 [G17-64 revised] ) ; and Jichi Medical University Alumni
   Association Project Grant 2020 [5-3] .
CR Amagai Y, 2010, J EPIDEMIOL, V20, P106, DOI 10.2188/jea.JE20090053
   Arora T, 2011, DIABETES CARE, V34, P2317, DOI 10.2337/dc11-0647
   Arroll B, 2003, BMJ-BRIT MED J, V327, P1144, DOI 10.1136/bmj.327.7424.1144
   Blasi C, 2000, PROG NEURO-PSYCHOPH, V24, P561, DOI 10.1016/S0278-5846(00)00093-2
   Buxton OM, 2010, DIABETES, V59, P2126, DOI 10.2337/db09-0699
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1016/0165-1781(89)90047-4
   Carrive P, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00257
   Chevassus Hugues, 2004, BMC Clin Pharmacol, V4, P3, DOI 10.1186/1472-6904-4-3
   Choi JW, 2018, J CLIN SLEEP MED, V14, P1669, DOI 10.5664/jcsm.7370
   Cooper SJ, 2005, APPETITE, V44, P133, DOI 10.1016/j.appet.2005.01.003
   Coughlin SR, 2004, EUR HEART J, V25, P735, DOI 10.1016/j.ehj.2004.02.021
   da Silva Andressa Alves, 2016, BMJ Open, V6, pe008119, DOI 10.1136/bmjopen-2015-008119
   Deng HB, 2017, SLEEP, V40, DOI 10.1093/sleep/zsx130
   Doi Y, 2000, PSYCHIAT RES, V97, P165, DOI 10.1016/S0165-1781(00)00232-8
   Fernandez-Mendoza J, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.117.005479
   Gramaglia E, 2014, J ENDOCRINOL INVEST, V37, P203, DOI 10.1007/s40618-013-0016-y
   Grottoli S, 1999, Pituitary, V2, P197, DOI 10.1023/A:1009992909247
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Huang WS, 2013, J CLIN PSYCHIAT, V74, pE433, DOI 10.4088/JCP.12m08181
   Huang YL, 2012, SLEEP MED, V13, P263, DOI 10.1016/j.sleep.2011.07.016
   Ishikawa Shizukiyo, 2002, J Epidemiol, V12, P408
   Kaneita Y, 2008, SLEEP, V31, P645, DOI 10.1093/sleep/31.5.645
   Kay-Stacey M, 2016, BMJ-BRIT MED J, V354, DOI 10.1136/bmj.i2123
   Kitajima T, 2004, NEUROSCI LETT, V355, P77, DOI 10.1016/j.neulet.2003.10.054
   Koren D, 2018, METABOLISM, V84, P67, DOI 10.1016/j.metabol.2018.04.001
   Li X, 2015, SLEEP MED, V16, P949, DOI 10.1016/j.sleep.2015.03.024
   Lin SC, 2016, SLEEP, V39, P1261, DOI 10.5665/sleep.5848
   Mesrine S, 2018, EUR J CLIN PHARMACOL, V74, P1475, DOI 10.1007/s00228-018-2515-4
   Nedeltcheva AV, 2012, OBESITY, V20, P1379, DOI 10.1038/oby.2012.97
   Ozone M, 2008, PHARMACOPSYCHIATRY, V41, P106, DOI 10.1055/s-2008-1058104
   Sieminski M, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0879-6
   Smiley A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112582
   Syauqy A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081848
   Takahashi Hiroki, 2013, Nihon Rinsho, V71, P257
   Troxel WM, 2010, SLEEP, V33, P1633, DOI 10.1093/sleep/33.12.1633
   Vgontzas AN, 2009, SLEEP, V32, P491, DOI 10.1093/sleep/32.4.491
   Wang Y, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-11431-6
   Whooley MA, 1997, J GEN INTERN MED, V12, P439, DOI 10.1046/j.1525-1497.1997.00076.x
   Yaggi HK, 2006, DIABETES CARE, V29, P657, DOI 10.2337/diacare.29.03.06.dc05-0879
   Yoda K, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0122521
NR 40
TC 5
Z9 5
U1 0
U2 4
PU JAPAN EPIDEMIOLOGICAL ASSOC
PI TOKYO
PA HONGO MT BLDG, 4 FL, 7-2-2, HONGO, BUNKYO-KU, TOKYO, JAPAN
SN 0917-5040
J9 J EPIDEMIOL
JI J. Epidemiol.
PD MAR
PY 2022
VL 32
IS 3
BP 145
EP 150
DI 10.2188/jea.JE20200361
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA YX4CE
UT WOS:000754052700001
PM 33162423
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pataky, Z
   Carrard, I
   Gay, V
   Thomas, A
   Carpentier, A
   Bobbioni-Harsch, E
   Golay, A
AF Pataky, Zoltan
   Carrard, Isabelle
   Gay, Valerie
   Thomas, Aurelien
   Carpentier, Anne
   Bobbioni-Harsch, Elisabetta
   Golay, Alain
TI Effects of a Weight Loss Program on Metabolic Syndrome, Eating Disorders
   and Psychological Outcomes: Mediation by Endocannabinoids?
SO OBESITY FACTS
LA English
DT Article
DE Weight loss; Metabolic syndrome; Endocannabinoids; Eating disorders;
   Quality of life; Patient education
ID LIFE-STYLE INTERVENTION; GASTRIC BYPASS; OBESE-PATIENTS; FATTY-ACIDS;
   DIETARY-FAT; RISK; REDUCTION; PLASMA; INDIVIDUALS; MANAGEMENT
AB Objective: To evaluate the effects of weight loss on endocannabinoids, cardiometabolic and psychological parameters, eating disorders (ED) as well as quality of life (QoL) and to elucidate the role of endocannabinoids in metabolic syndrome (MS). Methods: In total, 114 patients with obesity were prospectively included in a 12-month weight loss program. Plasma endocannabinoids were measured by mass spectrometry; ED, psychological and QoL-related parameters were evaluated by self-reported questionnaires; physical activity was measured by accelerometer. Nutritional assessment was done by a 3-day food diary. Results: Among completers (n = 87), body weight decreased in 35 patients (-9.1 +/- 8.6 kg), remained stable in 39 patients, and increased in 13 patients (+5.8 +/- 3.4 kg). 75% of patients with MS at baseline were free of MS at follow-up, and their baseline plasma N-palmitoylethanolamide (PEA) values were significantly lower when compared to patients with persisting MS. At baseline, there was a positive relationship between PEA and waist circumference (p = 0.005, R-2 = 0.08), fasting glucose (p < 0.0001, R-2 - 0.12), total cholesterol (p = 0.001, R-2 - 0.11), triglycerides (p = 0.001, R-2 = 0.11), LDL-cholesterol (p = 0.03, R-2 = 0.05) as well as depression score (p = 0.002, R-2 = 0.29). Conclusion: Plasma PEA might play a role in metabolic improvement after weight loss. Even in subjects without weight loss, a multidisciplinary intervention improves psychological outcomes, ED, and QoL. (C) 2018 The Author(s) Published by S. Karger GmbH, Freiburg
C1 [Pataky, Zoltan; Carrard, Isabelle; Gay, Valerie; Carpentier, Anne; Bobbioni-Harsch, Elisabetta; Golay, Alain] Univ Hosp Geneva, WHO, Collaborating Ctr, Serv Therapeut Educ Chron Dis, Geneva, Switzerland.
   [Pataky, Zoltan; Carrard, Isabelle; Gay, Valerie; Thomas, Aurelien; Carpentier, Anne; Bobbioni-Harsch, Elisabetta; Golay, Alain] Univ Geneva, Geneva, Switzerland.
   [Carrard, Isabelle] Univ Appl Sci & Arts Western Switzerland HES SO, Sch Hlth Sci, Dept Nutr & Dietet, Geneva, Switzerland.
   [Thomas, Aurelien] Univ Hosp Geneva, CURML, Unit Toxicol, Geneva, Switzerland.
C3 World Health Organization; University of Geneva; University of Geneva;
   University of Geneva
RP Pataky, Z (corresponding author), Univ Hosp Geneva, Serv Therapeut Educ Chron Dis, Chemin Venel 7, CH-1206 Geneva, Switzerland.
EM zoltan.pataky@hcuge.ch
RI Allet, Lara/C-2994-2009
OI Pataky, Zoltan/0000-0002-8720-3833; Carrard,
   Isabelle/0000-0002-2384-6696; Thomas, Aurelien/0000-0001-6790-2285
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   [Anonymous], 2000, PROTOCOLES ECHELLES
   [Anonymous], 2023, Motivational interviewing: helping people change and grow internet
   Beck A. T., 1996, BDI 2 INVENTAIRE DEP
   Beck AT, 1996, J PERS ASSESS, V67, P588, DOI 10.1207/s15327752jpa6703_13
   Borkoles E, 2016, MATURITAS, V83, P51, DOI 10.1016/j.maturitas.2015.09.010
   Bray GA, 2009, LANCET, V374, P1677, DOI 10.1016/S0140-6736(09)61457-4
   Carrard I, 2015, EAT WEIGHT DISORD-ST, V20, P137, DOI 10.1007/s40519-014-0148-x
   Cota D, 2003, J CLIN INVEST, V112, P423, DOI 10.1172/JCI17725
   Dall TM, 2015, AM J PREV MED, V48, P271, DOI 10.1016/j.amepre.2014.10.003
   DiLillo V, 2011, PSYCHIAT CLIN N AM, V34, P861, DOI 10.1016/j.psc.2011.08.003
   Ekelund U, 2007, DIABETES CARE, V30, P337, DOI 10.2337/dc06-1883
   Freedson PS, 1998, MED SCI SPORT EXER, V30, P777, DOI 10.1097/00005768-199805000-00021
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Gaesser GA, 1999, MED SCI SPORT EXER, V31, P1118, DOI 10.1097/00005768-199908000-00007
   Gatta-Cherifi B, 2016, INT J OBESITY, V40, P210, DOI 10.1038/ijo.2015.179
   Harding AH, 2004, AM J EPIDEMIOL, V159, P73, DOI 10.1093/aje/kwh004
   Hosseinpour-Niazi S, 2015, J HEALTH POPUL NUTR, V33, DOI 10.1186/s41043-015-0015-z
   Howard BV, 2006, JAMA-J AM MED ASSOC, V295, P655, DOI 10.1001/jama.295.6.655
   Jackson SL, 2015, LANCET DIABETES ENDO, V3, P173, DOI 10.1016/S2213-8587(14)70267-0
   Jensen MD, 2014, J AM COLL CARDIOL, V63, P2985, DOI 10.1016/j.jacc.2013.11.004
   Knowler William C, 2002, N Engl J Med, V346, P393, DOI 10.1056/NEJMoa012512
   Kolotkin RL, 2002, OBES RES, V10, P748, DOI 10.1038/oby.2002.102
   Magkos F, 2016, CELL METAB, V23, P591, DOI 10.1016/j.cmet.2016.02.005
   Mâsse LC, 2005, MED SCI SPORT EXER, V37, pS544, DOI 10.1249/01.mss.0000185674.09066.8a
   Mayneris-Perxachs J, 2014, CLIN NUTR, V33, P90, DOI 10.1016/j.clnu.2013.03.001
   Miller WC, 1999, MED SCI SPORT EXER, V31, P1129, DOI 10.1097/00005768-199908000-00008
   Montecucco F, 2015, THROMB HAEMOSTASIS, V113, P838, DOI 10.1160/TH14-06-0506
   Mudaliar U, 2016, PLOS MED, V13, DOI 10.1371/journal.pmed.1002095
   Pataky Z, 2013, EXP CLIN ENDOCR DIAB, V121, P20, DOI 10.1055/s-0032-1329957
   Quercioli A, 2017, INT J CARDIOL, V231, P1, DOI 10.1016/j.ijcard.2016.12.023
   Quercioli A, 2013, EUR HEART J, V34, P2063, DOI 10.1093/eurheartj/eht085
   Scherrer-Burri Florence, 2013, Soins, P23
   SCHOELLER DA, 1995, METABOLISM, V44, P18, DOI 10.1016/0026-0495(95)90204-X
   Singh V, 2015, CELL METAB, V22, P983, DOI 10.1016/j.cmet.2015.09.028
   Sirohi S, 2017, INT J OBESITY, V41, P412, DOI 10.1038/ijo.2016.235
   STUNKARD AJ, 1985, J PSYCHOSOM RES, V29, P71, DOI 10.1016/0022-3999(85)90010-8
   Wadden TA, 2006, OBESITY, V14, P737
   Warensjö E, 2006, AM J CLIN NUTR, V84, P442
   WEIR JBD, 1949, J PHYSIOL-LONDON, V109, P1, DOI 10.1113/jphysiol.1949.sp004363
   Westerterp KR, 2002, CURR OPIN CLIN NUTR, V5, P489, DOI 10.1097/00075197-200209000-00006
   Zhang XP, 2017, DIABETES RES CLIN PR, V123, P149, DOI 10.1016/j.diabres.2016.11.020
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 43
TC 13
Z9 14
U1 0
U2 7
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1662-4025
EI 1662-4033
J9 OBESITY FACTS
JI Obes. Facts
PY 2018
VL 11
IS 2
BP 144
EP 156
DI 10.1159/000487890
PG 13
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA GG5NK
UT WOS:000432742400007
PM 29631275
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sicras-Mainar, A
   Ruíz-Beato, E
   Navarro-Artieda, R
   Maurino, J
AF Sicras-Mainar, Antoni
   Ruiz-Beato, Elena
   Navarro-Artieda, Ruth
   Maurino, Jorge
TI Comorbidity and metabolic syndrome in patients with multiple sclerosis
   from Asturias and Catalonia, Spain
SO BMC NEUROLOGY
LA English
DT Article
DE Comorbidity; Metabolic syndrome; Multiple sclerosis; Electronic medical
   records
ID PREVALENCE; POPULATION; DISEASES; RISK
AB Background: The impact of comorbidity on multiple sclerosis (MS) is a new area of interest. Limited data on the risk factors of metabolic syndrome (MetS) is currently available. The aim of this study was to estimate the presence of comorbid conditions and MetS in a sample of adult patients with MS.
   Methods: A retrospective, cohort study was conducted using electronic medical records from 19 primary care centres in Catalonia and Asturias, Spain. The number of chronic diseases (diagnoses), the Charlson Comorbidity Index and the individual Case- mix Index were used to assess general comorbidity variables. MetS was defined using the National Cholesterol Education Program Adult Treatment Panel III. Patients were distributed into two groups according to the Expanded Disability Status Scale (EDSS) score: 0- 3.5 and 4- 10.
   Results: A total of 222 patients were studied (mean age = 45.5 (SD 12.5) years, 64.4% were female and 62.2% presented a diagnosis of relapsing- remitting MS). Mean EDSS score was 3.2 (SD 2.0). Depression (32.4%), dyslipidaemia (31.1%), hypertension (23.0%) and obesity (22.5%) were the most common comorbidities. Overall MetS prevalence was 31.1% (95% CI: 25.0- 37.2%). Patients with an EDSS >= 4.0 showed a significantly higher number of comorbidities (OR= 2.2; 95% CI: 1.7- 3.0; p< 0.001).
   Conclusion: MS patients had a high prevalence of MetS. Screening for comorbidity should be part of standard MS care. Further studies are necessary to confirm this association and the underlying mechanisms of MS and its comorbidities.
C1 [Sicras-Mainar, Antoni] Fdn Rediss Red Invest Serv Sanitarios, Barcelona, Spain.
   [Ruiz-Beato, Elena] Roche Farma SA, Hlth Econ & Outcomes Res Unit, Madrid, Spain.
   [Navarro-Artieda, Ruth] Hosp Badalona Germans Trias & Pujol, Dept Med Informat, Barcelona, Spain.
   [Maurino, Jorge] Roche Farma SA, Dept Med, Madrid, Spain.
C3 Hospital Germans Trias i Pujol; Roche Holding; ROCHE HOLDING SPAIN
RP Maurino, J (corresponding author), Roche Farma SA, Dept Med, Madrid, Spain.
EM jorge.maurino@roche.com
CR Arroyo R, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2016-014433
   Ayuso Guillermo Izquierdo, 2014, Med Clin (Barc), V143 Suppl 3, P7, DOI 10.1016/S0025-7753(15)30003-8
   Berrigan LI, 2016, NEUROLOGY
   Brück W, 2013, JAMA NEUROL, V70, P1315, DOI 10.1001/jamaneurol.2013.3510
   Candeliere-Merlicco A, 2016, MULT SCLER RELAT DIS, V9, P31, DOI 10.1016/j.msard.2016.06.003
   Capkun G, 2015, MULT SCLER RELAT DIS, V4, P546, DOI 10.1016/j.msard.2015.08.005
   CHARLSON ME, 1987, J CHRON DIS, V40, P373, DOI 10.1016/0021-9681(87)90171-8
   Comi G, 2017, LANCET, V389, P1347, DOI 10.1016/S0140-6736(16)32388-1
   Culpepper WJ, 2015, MULT SCLER J, V21, P261, DOI 10.1177/1352458515574151
   Estruch Bonaventura Casanova, 2014, Med Clin (Barc), V143 Suppl 3, P13, DOI 10.1016/S0025-7753(15)30004-X
   Fernández O, 2012, MULT SCLER J, V18, P372, DOI 10.1177/1352458511421917
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Guallar-Castillón P, 2014, REV ESP CARDIOL, V67, P367, DOI [10.1016/j.rec.2013.08.014, 10.1016/j.recesp.2013.08.014]
   Haghikia A, 2016, JAMA NEUROL, V73, P499, DOI 10.1001/jamaneurol.2015.5050
   Hajiebrahimi M, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0165027
   Howard J, 2016, NEUROL CLIN, V34, P919, DOI 10.1016/j.ncl.2016.06.016
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   KURTZKE JF, 1983, NEUROLOGY, V33, P1444, DOI 10.1212/WNL.33.11.1444
   Lalmohamed A, 2012, EUR J NEUROL, V19, P1007, DOI 10.1111/j.1468-1331.2012.03668.x
   Lamberts H, 1993, INT CLASSIFICATION P
   Marrie RA, 2010, NEUROLOGY, V74, P1041, DOI 10.1212/WNL.0b013e3181d6b125
   Marrie R. A., 2017, NAT REV NEUROL
   Marrie Ruth Ann, 2016, Int J MS Care, V18, P271, DOI 10.7224/1537-2073.2016-086
   Marrie RA, 2015, MULT SCLER J, V21, P263, DOI 10.1177/1352458514564491
   Marrie RA, 2015, NEUROLOGY, V84, P350, DOI 10.1212/WNL.0000000000001187
   Motheral B, 2003, VALUE HEALTH, V6, P90, DOI 10.1046/j.1524-4733.2003.00242.x
   Otero-Romero S, 2013, MULT SCLER J, V19, P245, DOI 10.1177/1352458512444751
   Pinhas-Hamiel O, 2015, EUR J NEUROL, V22, P1275, DOI 10.1111/ene.12738
   Sattar N, 2003, CIRCULATION, V108, P414, DOI 10.1161/01.CIR.0000080897.52664.94
   van Zanten JJCSV, 2016, MULT SCLER J, V22, P1250, DOI 10.1177/1352458516644340
   Versini M, 2014, AUTOIMMUN REV, V13, P981, DOI 10.1016/j.autrev.2014.07.001
   WEINER JP, 1991, MED CARE, V29, P452, DOI 10.1097/00005650-199105000-00006
   Wens I, 2013, MULT SCLER J, V19, P1556, DOI 10.1177/1352458513504252
   World Health Organization, 1999, INT CLASS DIS ICD 9
NR 34
TC 35
Z9 36
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2377
J9 BMC NEUROL
JI BMC Neurol.
PD JUL 17
PY 2017
VL 17
AR 134
DI 10.1186/s12883-017-0914-2
PG 6
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA FA8MP
UT WOS:000405700400002
PM 28716070
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Carney, R
   Cotter, J
   Bradshaw, T
   Yung, AR
AF Carney, Rebekah
   Cotter, Jack
   Bradshaw, Tim
   Yung, Alison R.
TI Examining the physical health and lifestyle of young people at
   ultra-high risk for psychosis: A qualitative study involving service
   users, parents and clinicians
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Psychosis; Prodrome; At-risk mental state; Metabolic health; Health
   promotion
ID NEGATIVE SYMPTOMS; EXERCISE; NEUROCOGNITION; INDIVIDUALS; STATE; TIME
AB Emerging evidence suggests young people at ultra-high risk for psychosis (UHR) are also at-risk for poor physical health, and display high rates of modifiable cardiometabolic risk factors. However, before we can develop effective interventions there is a need to understand factors affecting lifestyle choices in the UHR group. We conducted semi-structured qualitative interviews with 20 UHR individuals (50% male; mean age 21.7), 5 parents (4 mothers, 1 father), and 6 clinicians from early intervention services in the Northwest of England to identify barriers and facilitators to living a healthy lifestyle, including achieving regular exercise, eating well and refraining from excessive substance use. Thematic analysis revealed the main barriers to living a healthy lifestyle related to psychiatric symptoms, beliefs about self, social withdrawal and practical considerations such as accessibility and cost. Provision of social support and promoting autonomy emerged as the two main themes which would facilitate a healthy lifestyle. Promoting physical health in people with emerging symptoms of psychosis is an important, yet neglected area of mental health practice and warrants further investigation. UHR individuals experience numerous barriers to living a healthy lifestyle, and interventions should focus primarily on targeting autonomous motivation and providing social support to facilitate this change.
C1 [Carney, Rebekah; Cotter, Jack; Yung, Alison R.] Univ Manchester, Div Psychol & Mental Hlth, Room 3-306,Jean McFarlane Bldg,Oxford Rd, Manchester M13 9PL, Lancs, England.
   [Bradshaw, Tim] Univ Manchester, Div Nursing Midwifery & Social Work, Manchester, Lancs, England.
   [Yung, Alison R.] Greater Manchester West Mental Hlth NHS Fdn Trust, Manchester, Lancs, England.
C3 University of Manchester; University of Manchester
RP Carney, R (corresponding author), Univ Manchester, Div Psychol & Mental Hlth, Room 3-306,Jean McFarlane Bldg,Oxford Rd, Manchester M13 9PL, Lancs, England.
EM rebekah.rebekah@postgrad.manchester.ac.uk
RI Carney, Rebekah/AAO-5205-2021; Yung, Alison/N-6729-2019
OI Yung, Alison/0000-0002-0401-9791; Carney, Rebekah/0000-0002-2859-6825
FU Economic and Social Research Council [ES/J500094/1]
FX R.C is supported by the Economic and Social Research Council
   [ES/J500094/1]. We would like to thank all participants and staff
   members who assisted with recruitment at the participating sites. We
   would like to extend particular thanks to Matt Riley for helping us
   throughout the course of the study.
CR [Anonymous], EARLY INTERV PSYCHIA
   [Anonymous], PSYCHIAT RES
   [Anonymous], SCHIZOPHR B
   [Anonymous], PSYCHIAIR Q
   [Anonymous], AUST N Z J PSYCHIAT
   [Anonymous], SELL DETERMINATION
   [Anonymous], 2016, Implementing the Early Intervention in Psychosis access and Waiting Time standard: Guidance
   [Anonymous], 2015, NVivo qualitative data analysis Software
   Archie S, 2003, CAN J PSYCHIAT, V48, P628, DOI 10.1177/070674370304800910
   Ben-David S, 2014, PSYCHIAT SERV, V65, P1499, DOI 10.1176/appi.ps.201300527
   Bradshaw T, 2012, INT J NURS STUD, V49, P398, DOI 10.1016/j.ijnurstu.2011.10.008
   Braun V., 2006, Qual. Res. Psychol., V3, P77, DOI [10.1191/1478088706qp063oa, DOI 10.1191/1478088706QP063OA, DOI 10.1080/10875549.2021.1929659]
   Byrne R, 2010, EARLY INTERV PSYCHIA, V4, P162, DOI 10.1111/j.1751-7893.2010.00171.x
   Carney R, 2017, SCHIZOPHR RES, V181, P23, DOI 10.1016/j.schres.2016.08.026
   Carney R, 2018, EARLY INTERV PSYCHIA, V12, P153, DOI 10.1111/eip.12288
   Carney R, 2016, SCHIZOPHR RES, V170, P290, DOI 10.1016/j.schres.2016.01.010
   Cordes J, 2017, SCHIZOPHR RES, V181, P38, DOI 10.1016/j.schres.2016.09.012
   Cotter J., 2016, Schizophrenia Research
   Cotter J, 2014, SCHIZOPHR RES, V159, P267, DOI 10.1016/j.schres.2014.09.012
   Curtis J, 2016, EARLY INTERV PSYCHIA, V10, P267, DOI 10.1111/eip.12230
   Firth J, 2016, PSYCHOL MED, V46, P2869, DOI 10.1017/S0033291716001732
   Firth J, 2015, PSYCHOL MED, V45, P1343, DOI 10.1017/S0033291714003110
   Firth J, 2018, EARLY INTERV PSYCHIA, V12, P578, DOI 10.1111/eip.12365
   Firth J, 2016, BMC PSYCHIATRY, V16, DOI 10.1186/s12888-016-0751-7
   Fusar-Poli P, 2013, JAMA PSYCHIAT, V70, P107, DOI 10.1001/jamapsychiatry.2013.269
   Fusar-Poli P, 2012, ARCH GEN PSYCHIAT, V69, P220, DOI 10.1001/archgenpsychiatry.2011.1472
   Glenthoj LB, 2017, ACTA PSYCHIAT SCAND, V135, P250, DOI 10.1111/acps.12682
   Laursen TM, 2012, CURR OPIN PSYCHIATR, V25, P83, DOI 10.1097/YCO.0b013e32835035ca
   Lin A, 2015, AM J PSYCHIAT, V172, P249, DOI 10.1176/appi.ajp.2014.13030418
   Meyer EC, 2014, SCHIZOPHRENIA BULL, V40, P1452, DOI 10.1093/schbul/sbt235
   Michie S, 2011, IMPLEMENT SCI, V6, DOI 10.1186/1748-5908-6-42
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Plaistow J, 2014, EARLY INTERV PSYCHIA, V8, P12, DOI 10.1111/eip.12060
   Shiers D, 2015, BRIT J PSYCHIAT, V207, P471, DOI 10.1192/bjp.bp.114.152595
   Sormunen E, 2017, NPJ SCHIZOPHR, V3, DOI 10.1038/s41537-016-0007-z
   Tsiachristas A, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2016-012611
   Yung AR, 2015, PSYCHOL MED, V45, P3453, DOI 10.1017/S003329171500135X
   Yung AR, 2004, SCHIZOPHR RES, V67, P131, DOI 10.1016/S0920-9964(03)00192-0
   Yung AR, 2003, SCHIZOPHR RES, V60, P21, DOI 10.1016/S0920-9964(02)00167-6
NR 39
TC 26
Z9 34
U1 0
U2 13
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD SEP
PY 2017
VL 255
BP 87
EP 93
DI 10.1016/j.psychres.2017.05.023
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FE4IO
UT WOS:000408177800014
PM 28531821
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Peleli, M
   Hezel, M
   Zollbrecht, C
   Persson, AEG
   Lundberg, JO
   Weitzberg, E
   Fredholm, BB
   Carlström, M
AF Peleli, Maria
   Hezel, Michael
   Zollbrecht, Christa
   Persson, A. Erik G.
   Lundberg, Jon O.
   Weitzberg, Eddie
   Fredholm, Bertil B.
   Carlstrom, Mattias
TI In adenosine A2B knockouts acute treatment with inorganic
   nitrate improves glucose disposal, oxidative stress, and AMPK signaling
   in the liver
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE insulin resistance; metabolic syndrome; NADPH oxidase; nitric oxide;
   nitrite; superoxide; obesity; type 2 diabetes
ID ACTIVATED PROTEIN-KINASE; NITRIC-OXIDE; DIETARY NITRATE; NADPH OXIDASE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; BLOOD-PRESSURE; ENDOTHELIAL
   FUNCTION; NAD(P)H OXIDASE; ADIPOSE-TISSUE
AB Rationale: Accumulating studies suggest that nitric oxide (NO) deficiency and oxidative stress are central pathological mechanisms in type 2 diabetes (T2D). Recent findings demonstrate therapeutic effects by boosting the nitrate-nitrite-NO pathway, which is an alternative pathway for NO formation. This study aimed at investigating the acute effects of inorganic nitrate on glucose and insulin signaling in adenosine A2B receptor knockout mice (A(2B)(-/-), a genetic mouse model of impaired metabolic regulation.
   Methods: Acute effects of nitrate treatment were investigated in aged wild-type (WT) and A(2B)(-/-) mice. One hour after injection with nitrate (0.1 mmol/kg, i.p.) or placebo, metabolic regulation was evaluated by intraperitoneal glucose and insulin tolerance tests. NADPH oxidase-mediated superoxide production and AMPK phosphorylation were measured in livers obtained from non-treated or glucose-treated mice, with or without prior nitrate injection. Plasma was used to determine insulin resistance (HOMA-IR) and NO signaling.
   Results: A(2B)(-/-) displayed increased body weight, reduced glucose clearance, and attenuated overall insulin responses compared with age-matched WT mice. Nitrate treatment increased circulating levels of nitrate, nitrite and cGMP in the A(2B)(-/-), and improved glucose clearance. In WT mice, however, nitrate treatment did not influence glucose clearance. HOMA-IR increased following glucose injection in the A(2B)(-/-), but remained at basal levels in mice pretreated with nitrate. NADPH oxidase activity in livers from A(2B)(-/-), but not WT mice, was reduced by nitrate treatment. Livers from A(2B)(-/-) displayed reduced AMPK phosphorylation compared with WT mice, and this was increased by nitrate treatment. Finally, injection with the anti-diabetic agent metformin induced similar therapeutic effects in the A(2B)(-/-) as observed with nitrate.
   Conclusion: The A(2B)(-/-) mouse is a genetic mouse model of metabolic syndrome. Acute treatment with nitrate improved the metabolic profile in it, at least partly via reduction in oxidative stress and improved AMPK signaling in the liver.
C1 [Peleli, Maria; Hezel, Michael; Zollbrecht, Christa; Lundberg, Jon O.; Weitzberg, Eddie; Fredholm, Bertil B.; Carlstrom, Mattias] Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden.
   [Persson, A. Erik G.] Uppsala Univ, Dept Med Cell Biol, Stockholm, Sweden.
C3 Karolinska Institutet; Uppsala University
RP Carlström, M (corresponding author), Karolinska Inst, Dept Physiol & Pharmacol, Nanna Svartz Vag 2, S-17177 Stockholm, Sweden.
EM mattias.carlstrom@ki.se
RI Peleli, Maria/AAQ-2326-2021; Carlstrom, Mattias/E-7350-2015
OI Lundberg, Jon/0000-0002-0174-5210; Carlstrom,
   Mattias/0000-0001-9923-8729
FU Swedish Research Council [521-2011-2639]; Swedish Heart and Lung
   Foundation [20140448]; David and Astrid Hagelen Foundation; Jeanssons
   Foundation [J520 13-00064]; Stockholm City Council (ALF); Bodossaki
   Foundation (Athens, Greece); Karolinska Institutet
FX We thank Eva Lindgren, Annika Olsson, Carina Nihlen, and Margareta
   Stensdotter (Department of Physiology and Pharmacology, Karolinska
   Institutet) for excellent technical contribution. This work was
   supported by grants from the Swedish Research Council (521-2011-2639),
   the Swedish Heart and Lung Foundation (20140448), David and Astrid
   Hagelen Foundation, Jeanssons Foundation (J520 13-00064), Stockholm City
   Council (ALF), the Bodossaki Foundation (Athens, Greece), and by
   KID-funding from the Karolinska Institutet.
CR Adachi M, 2008, HEPATOLOGY, V47, P677, DOI 10.1002/hep.21991
   Alba G, 2004, FEBS LETT, V573, P219, DOI 10.1016/j.febslet.2004.07.077
   Ansari HR, 2007, AM J PHYSIOL-HEART C, V292, pH719, DOI 10.1152/ajpheart.00593.2006
   Araujo M, 2014, ANTIOXID REDOX SIGN, V20, P74, DOI 10.1089/ars.2013.5259
   Bahadoran Z, 2015, NUTR METAB, V12, DOI 10.1186/s12986-015-0013-6
   Balteau M, 2014, AM J PHYSIOL-HEART C, V307, pH1120, DOI 10.1152/ajpheart.00210.2014
   Bechmann LP, 2012, J HEPATOL, V56, P952, DOI 10.1016/j.jhep.2011.08.025
   Carlström M, 2011, AM J PHYSIOL-RENAL, V300, pF457, DOI 10.1152/ajprenal.00567.2010
   Carlström M, 2013, ACTA PHYSIOL, V207, P732, DOI 10.1111/apha.12079
   Carlström M, 2011, CARDIOVASC RES, V89, P574, DOI 10.1093/cvr/cvq366
   Carlström M, 2011, CURR CARDIOVASC RISK, V5, P29, DOI 10.1007/s12170-010-0139-z
   Carlström M, 2010, P NATL ACAD SCI USA, V107, P17716, DOI 10.1073/pnas.1008872107
   Ceolotto G, 2007, ARTERIOSCL THROM VAS, V27, P2627, DOI 10.1161/ATVBAHA.107.155762
   Cermak NM, 2015, NUTR RES, V35, P674, DOI 10.1016/j.nutres.2015.05.017
   Chen JF, 2013, NAT REV DRUG DISCOV, V12, P265, DOI 10.1038/nrd3955
   Csóka B, 2014, DIABETES, V63, P850, DOI 10.2337/db13-0573
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Gao X, 2015, HYPERTENSION, V65, P161, DOI 10.1161/HYPERTENSIONAHA.114.04222
   Gilchrist M, 2014, NITRIC OXIDE-BIOL CH, V40, P67, DOI 10.1016/j.niox.2014.05.003
   Gilchrist M, 2013, FREE RADICAL BIO MED, V60, P89, DOI 10.1016/j.freeradbiomed.2013.01.024
   Gnad T, 2014, NATURE, V516, P395, DOI 10.1038/nature13816
   Guichard C, 2008, BIOCHEM SOC T, V36, P920, DOI 10.1042/BST0360920
   Hezel MP, 2015, REDOX BIOL, V5, P234, DOI 10.1016/j.redox.2015.05.004
   Jiang H, 2014, FREE RADICAL BIO MED, V67, P51, DOI 10.1016/j.freeradbiomed.2013.10.809
   Johnston-Cox H, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0040584
   Joris PJ, 2013, ATHEROSCLEROSIS, V231, P78, DOI 10.1016/j.atherosclerosis.2013.09.001
   Khalifi S, 2015, NITRIC OXIDE-BIOL CH, V44, P24, DOI 10.1016/j.niox.2014.11.011
   Kraegen EW, 2006, AM J PHYSIOL-ENDOC M, V290, pE471, DOI 10.1152/ajpendo.00316.2005
   Litvinova L, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00020
   Lundberg JO, 2008, NAT REV DRUG DISCOV, V7, DOI [10.1038/nrd2466-c2, 10.1038/nrd2466]
   Lundberg JO, 2011, CARDIOVASC RES, V89, P525, DOI 10.1093/cvr/cvq325
   Lundberg JO, 2009, NAT CHEM BIOL, V5, P865, DOI 10.1038/nchembio.260
   Montenegro MF, 2011, FREE RADICAL BIO MED, V51, P144, DOI 10.1016/j.freeradbiomed.2011.04.005
   Nyström T, 2012, FREE RADICAL BIO MED, V53, P1017, DOI 10.1016/j.freeradbiomed.2012.06.031
   Ohtake K, 2015, NITRIC OXIDE-BIOL CH, V44, P31, DOI 10.1016/j.niox.2014.11.009
   Olanrewaju HA, 2000, GEN PHARMACOL-VASC S, V35, P171, DOI 10.1016/S0306-3623(01)00107-0
   Peralta C, 1999, HEPATOLOGY, V29, P126, DOI 10.1002/hep.510290104
   Piwkowska A, 2010, BIOCHEM BIOPH RES CO, V393, P268, DOI 10.1016/j.bbrc.2010.01.119
   Pride CK, 2014, CARDIOVASC RES, V101, P57, DOI 10.1093/cvr/cvt224
   Silva BR, 2012, FRONT PHYSIOL, V3, DOI 10.3389/fphys.2012.00441
   Singamsetty S, 2015, J PHYSIOL-LONDON, V593, P3135, DOI 10.1113/JP270386
   Towler MC, 2007, CIRC RES, V100, P328, DOI 10.1161/01.RES.0000256090.42690.05
   Viana AYI, 2006, DIABETES RES CLIN PR, V73, P135, DOI 10.1016/j.diabres.2005.12.011
   Wang SB, 2012, CLIN SCI, V122, P555, DOI 10.1042/CS20110625
   Weitzberg E, 2013, ANNU REV NUTR, V33, P129, DOI 10.1146/annurev-nutr-071812-161159
   Wink DA, 2001, ANTIOXID REDOX SIGN, V3, P203, DOI 10.1089/152308601300185179
   Yang T, 2015, DIABETOLOGIA, V58, P1610, DOI 10.1007/s00125-015-3570-3
   Yang T, 2015, FREE RADICAL BIO MED, V83, P159, DOI 10.1016/j.freeradbiomed.2015.02.016
NR 48
TC 39
Z9 44
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD AUG 7
PY 2015
VL 6
AR 222
DI 10.3389/fphys.2015.00222
PG 9
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA CQ2ZS
UT WOS:000360471900002
PM 26300787
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fosså, SD
   Fung, C
   Dahl, AA
AF Fossa, S. D.
   Fung, C.
   Dahl, A. A.
TI Late adverse outcomes after treatment of testicular cancer
SO ONKOLOGE
LA English
DT Review
DE Cancer survivors; Mortality; Cardiovascular disease; Risk factors;
   Toxicity
ID GERM-CELL CANCER; LONG-TERM; AMERICAN SOCIETY; RENAL-FUNCTION;
   SURVIVORS; CHEMOTHERAPY; BLEOMYCIN; CISPLATIN; FATIGUE; NONSEMINOMA
AB Background. Modern oncological treatment has rendered testicular cancer (TC) a curative malignant disease but there is a risk of decreasing survival and reduced healthrelated quality of life (HR-QoL) related to long-termadverse health outcomes (AHOs).
   Aim. To provide an overview on AHOs after oncological treatment of TC.
   Material and methods. Summary of published studies and previous reviews.
   Results. Relative survival rates decrease among TC survivors 25 years after diagnosis, mainly due to treatment-related second cancer and/or cardiovascular disease, the latter mediated by components of the metabolic syndrome. With increasing age cisplatin-induced ototoxicity becomes a clinical problem in patients, whereas reported peripheral neurotoxicity only exceptionally achieves major clinical relevance. Anxiety but not depression represents the dominating psychological problem. In most patients HR-QoL is good, but working abilitymay be reduced by very intensive treatment.
   Conclusion. Awareness of long-term AHOs among TC survivors and health professionals can contribute to reduce long-term morbidity and mortality and to improve QoL by initiating early preventive and therapeutic measures. Radiotherapy should be avoided as much as possible during risk-adapted treatment of TC. Existing data indicate premature aging among strongly treated TC survivors but larger studies and longer follow-up in longitudinal studies are required to confirm these preliminary observations.
C1 [Fossa, S. D.; Dahl, A. A.] Oslo Univ Hosp, Norwegian Radium Hosp, Natl Advisory Unit Late Effects Canc Treatment, Dept Oncol, Pb 4953, N-0424 Oslo, Norway.
   [Fung, C.] Univ Rochester, Med Ctr, James P Wilmot Canc Inst, Rochester, NY 14627 USA.
C3 University of Oslo; University of Rochester
RP Fosså, SD (corresponding author), Oslo Univ Hosp, Norwegian Radium Hosp, Natl Advisory Unit Late Effects Canc Treatment, Dept Oncol, Pb 4953, N-0424 Oslo, Norway.
EM sopfos@ous-hf.no
CR Bandak M, 2016, ANDROLOGY-US, V4, P382, DOI 10.1111/andr.12177
   Bower JE, 2014, NAT REV CLIN ONCOL, V11, P597, DOI 10.1038/nrclinonc.2014.127
   Bower JE, 2014, J CLIN ONCOL, V32, P1840, DOI 10.1200/JCO.2013.53.4495
   Brydoy M, 2005, JNCI-J NATL CANCER I, V97, P1580, DOI 10.1093/jnci/dji339
   Cappuccio F, 2018, EUR REV MED PHARMACO, V22, P645, DOI 10.26355/eurrev_201802_14290
   Chovanec M, 2017, ANN ONCOL, V28, P2670, DOI 10.1093/annonc/mdx360
   Classen J, 2004, BRIT J CANCER, V90, P2305, DOI 10.1038/sj.bjc.6601867
   Eberhard J, 2009, J SEX MED, V6, P1979, DOI 10.1111/j.1743-6109.2009.01298.x
   EINHORN LH, 1977, ANN INTERN MED, V87, P293, DOI 10.7326/0003-4819-87-3-293
   Feldman DR, 2018, CLIN GENITOURIN CANC, V16, pE761, DOI 10.1016/j.clgc.2018.01.011
   Fosså SD, 2002, ANN ONCOL, V13, P222, DOI 10.1093/annonc/mdf048
   Frisina RD, 2016, J CLIN ONCOL, V34, P2712, DOI 10.1200/JCO.2016.66.8822
   Fung C, 2018, ADV UROL, V2018, DOI 10.1155/2018/8671832
   Fung C, 2015, J CLIN ONCOL, V33, P3105, DOI 10.1200/JCO.2014.60.3654
   Fung C, 2013, J CLIN ONCOL, V31, P3807, DOI 10.1200/JCO.2013.50.3409
   HANSEN SW, 1988, J CLIN ONCOL, V6, P1728, DOI 10.1200/JCO.1988.6.11.1728
   Haugnes HS, 2012, J CLIN ONCOL, V30, P3752, DOI 10.1200/JCO.2012.43.4431
   Haugnes HS., 2018, ACTA ONCOL, P1
   Hershman DL, 2014, J CLIN ONCOL, V32, P1941, DOI 10.1200/JCO.2013.54.0914
   Jankowska M, 2012, REP PRACT ONCOL RADI, V17, P54, DOI 10.1016/j.rpor.2011.11.001
   Kier MG, 2016, JAMA ONCOL, V2, P1624, DOI 10.1001/jamaoncol.2016.3651
   Kvammen O, 2016, CANCER EPIDEM BIOMAR, V25, P773, DOI 10.1158/1055-9965.EPI-15-1153
   Lauritsen J, 2016, J CLIN ONCOL, V34, P1492, DOI 10.1200/JCO.2015.64.8451
   Loren AW, 2013, J CLIN ONCOL, V31, P2500, DOI 10.1200/JCO.2013.49.2678
   Nord C, 2015, ACTA ONCOL, V54, P1770, DOI 10.3109/0284186X.2015.1020967
   Skakkebæk NE, 2001, HUM REPROD, V16, P972, DOI 10.1093/humrep/16.5.972
   Smith A, 2018, PSYCHO-ONCOLOGY, V27, P1129, DOI 10.1002/pon.4596
   Sprauten M, 2015, ANN ONCOL, V26, P2133, DOI 10.1093/annonc/mdv328
   Sprauten M, 2014, J CLIN ONCOL, V32, P571, DOI 10.1200/JCO.2013.51.2715
   Sprauten M, 2012, J CLIN ONCOL, V30, P300, DOI 10.1200/JCO.2011.37.4025
   Travis LB, 2005, JNCI-J NATL CANCER I, V97, P1354, DOI 10.1093/jnci/dji278
NR 31
TC 3
Z9 5
U1 0
U2 7
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0947-8965
EI 1433-0415
J9 ONKOLOGE
JI Onkologe
PD NOV
PY 2018
VL 24
SU 2
BP S104
EP S109
DI 10.1007/s00761-018-0442-8
PG 6
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA GZ8QL
UT WOS:000449757500003
DA 2025-06-11
ER

PT J
AU Marrone, G
   Basilicata, M
   Di Lauro, M
   Vita, C
   Masci, C
   Klinger, FG
   Cornali, K
   Maddaloni, G
   Bollero, P
   De Lorenzo, A
   Noce, A
AF Marrone, Giulia
   Basilicata, Michele
   Di Lauro, Manuela
   Vita, Chiara
   Masci, Claudia
   Klinger, Francesca Gioia
   Cornali, Kevin
   Maddaloni, Gianluca
   Bollero, Patrizio
   De Lorenzo, Antonino
   Noce, Annalisa
TI Healthy Effects of Pomegranate (Punica granatum L.) in Internal
   Medicine and Dentistry
SO APPLIED SCIENCES-BASEL
LA English
DT Review
DE ellagitannins; ellagic acid; circular economy; chronic non-communicable
   diseases; cancer; metabolic syndrome; oral health; periodontitis
ID PROSTATE-CANCER CELLS; ELLAGIC ACID; IN-VITRO; OXIDATIVE STRESS; FRUIT
   EXTRACT; COLON-CANCER; GENE-EXPRESSION; FLOWER EXTRACT; PLANT-EXTRACTS;
   PEEL EXTRACTS
AB Punica granatum L., commonly known as pomegranate, is a typical fruit of Asia, Mediterranean countries, the Middle East and the USA. While in ancient times pomegranate was considered an ornamental plant, nowadays numerous scientific studies have highlighted its antioxidant and anti-radical activities, making it a "superfood". Pomegranate presents a high content of natural bioactive compounds (NBCs), and its consumption appears to exert numerous healthy effects, in particular, in several pathological conditions as metabolic syndrome, cancer, nephrolithiasis, urinary tract infections and neurodegenerative diseases. Moreover, recent studies have pointed out the possible beneficial action of pomegranate on oral health. For these reasons, the utility of pomegranate in internal medicine and dentistry represents a promising field, as it could enable the development of innovative natural adjuvant therapies and empower standard pharmaceutical therapies.
C1 [Marrone, Giulia; Di Lauro, Manuela; Masci, Claudia; Cornali, Kevin; Noce, Annalisa] Univ Roma Tor Vergata, Dept Syst Med, UOSD Nephrol & Dialysis, I-00133 Rome, Italy.
   [Basilicata, Michele] Univ Roma Tor Vergata, Dept Expt Med & Surg, UOSD Special Care Dent, I-00133 Rome, Italy.
   [Basilicata, Michele; Klinger, Francesca Gioia] St Camillus Int Univ Hlth & Med Sci, Rome, Italy.
   [Vita, Chiara] Univ Ctr Citta Prato Educ, Sci Serv Univ Florence, QuMAP PIN, I-59100 Prato, Italy.
   [Maddaloni, Gianluca] Supreme Fruit SRL, I-04012 Cisterna Latina, Italy.
   [Bollero, Patrizio] Univ Roma Tor Vergata, Dept Syst Med, UOSD Special Care Dent, I-00133 Rome, Italy.
   [De Lorenzo, Antonino] Univ Roma Tor Vergata, Dept Biomed & Prevent, Sect Clin Nutr & Nutrigen, Via Montpellier 1, I-00133 Rome, Italy.
C3 University of Rome Tor Vergata; University of Rome Tor Vergata;
   University of Rome Tor Vergata; University of Rome Tor Vergata
RP Di Lauro, M (corresponding author), Univ Roma Tor Vergata, Dept Syst Med, UOSD Nephrol & Dialysis, I-00133 Rome, Italy.; Basilicata, M (corresponding author), Univ Roma Tor Vergata, Dept Expt Med & Surg, UOSD Special Care Dent, I-00133 Rome, Italy.; Basilicata, M (corresponding author), St Camillus Int Univ Hlth & Med Sci, Rome, Italy.
EM giulia.marrone@uniroma2.it; michele.basilicata@ptvonline.it;
   manuela.dilauro@ptvonline.it; chiara.vita@pin.unifi.it;
   masciclaudia@gmail.com; francesca.klinger@unicamillus.org;
   cornali.kevin@hotmail.it; gianluca7519@gmail.com;
   patrizio.bollero@ptvonline.it; annalisa.noce@uniroma2.it
RI Klinger, Francesca Gioia/K-6587-2018; Marrone, Giulia/IQR-7760-2023;
   Vita, Chiara/LSI-6514-2024; Noce, Annalisa/B-5558-2019; Di Lauro,
   Manuela/AAB-9784-2022
OI NOCE, ANNALISA/0000-0003-1310-3730; De Lorenzo,
   Antonino/0000-0001-6524-4493; Klinger, Francesca
   Gioia/0000-0001-6744-0850; Di Lauro, Manuela/0000-0001-8118-1330;
   Marrone, Giulia/0000-0002-5854-2086
CR Abdulhadi HL, 2022, MOL CELL BIOCHEM, V477, P2817, DOI 10.1007/s11010-022-04478-1
   Abid M, 2017, J FOOD SCI TECH MYS, V54, P2890, DOI 10.1007/s13197-017-2727-0
   Abidov M, 2010, DIABETES OBES METAB, V12, P72, DOI 10.1111/j.1463-1326.2009.01132.x
   Adams LS, 2006, J AGR FOOD CHEM, V54, P980, DOI 10.1021/jf052005r
   Adams LS, 2010, CANCER PREV RES, V3, P108, DOI 10.1158/1940-6207.CAPR-08-0225
   Adjakly M, 2015, ANN ENDOCRINOL-PARIS, V76, P25, DOI 10.1016/j.ando.2014.09.001
   Aguilar-Zárate P, 2017, PHYTOCHEM ANALYSIS, V28, P433, DOI 10.1002/pca.2691
   Ahuja S., 2011, Journal of the International Clinical Dental Research Organization, V3, P29, DOI [10.4103/2231-0754.115776, DOI 10.4103/2231-0754.115776]
   Akhtar S, 2015, FOOD CHEM, V174, P417, DOI 10.1016/j.foodchem.2014.11.035
   Al-Muammar MN, 2012, NUTRITION, V28, P595, DOI 10.1016/j.nut.2011.11.013
   Albrecht M, 2004, J MED FOOD, V7, P274, DOI 10.1089/1096620041938704
   Alexandre EMC, 2019, FOOD RES INT, V115, P167, DOI 10.1016/j.foodres.2018.08.044
   Almowallad S, 2020, PHARMACEUTICALS-BASE, V13, DOI 10.3390/ph13110372
   Ambigaipalan P, 2016, J AGR FOOD CHEM, V64, P6584, DOI 10.1021/acs.jafc.6b02950
   [Anonymous], 2019, LANCET, V394, P1880, DOI 10.1016/S0140-6736(19)32795-3
   Batista ALA, 2014, COMPLEMENT THER CLIN, V20, P93, DOI 10.1016/j.ctcp.2013.08.002
   Aviram M, 2000, AM J CLIN NUTR, V71, P1062
   Bahari H, 2024, DIAB MET SYND CLIN R, V18, DOI 10.1016/j.dsx.2024.102940
   Banihani S, 2013, NUTR RES, V33, P341, DOI 10.1016/j.nutres.2013.03.003
   Barbehenn RV, 2011, PHYTOCHEMISTRY, V72, P1551, DOI 10.1016/j.phytochem.2011.01.040
   Barbieri M, 2019, J PHARMACEUT BIOMED, V166, P90, DOI 10.1016/j.jpba.2018.12.033
   Bellesia A, 2015, INT J FOOD SCI NUTR, V66, P85, DOI 10.3109/09637486.2014.953455
   BenSaad LA, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1555-0
   Berköz M, 2020, GEN PHYSIOL BIOPHYS, V39, P557, DOI 10.4149/gpb_2020024
   Bhadbhade SJ, 2011, QUINTESSENCE INT, V42, P29
   Bialonska D, 2010, INT J FOOD MICROBIOL, V140, P175, DOI 10.1016/j.ijfoodmicro.2010.03.038
   Bielli P, 2002, CELL MOL LIFE SCI, V59, P1413, DOI 10.1007/s00018-002-8519-2
   Bobasa EM, 2021, FOOD CHEM, V358, DOI 10.1016/j.foodchem.2021.129833
   Boussetta T, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006458
   Braidy N, 2016, ONCOTARGET, V7, P64589, DOI 10.18632/oncotarget.10905
   Brookes ZLS, 2020, J DENT, V103, DOI 10.1016/j.jdent.2020.103497
   Brown JS, 2023, MOL CANCER RES, V21, P1142, DOI 10.1158/1541-7786.MCR-23-0411
   Espín JC, 2007, PHYTOCHEMISTRY, V68, P2986, DOI 10.1016/j.phytochem.2007.09.014
   Carranza Fermin A., 2006, Carranza's Clinical Periodontology
   Castonguay A, 1997, INT J ONCOL, V10, P367
   Chen HS, 2015, INT J ONCOL, V46, P1730, DOI 10.3892/ijo.2015.2870
   Cheng X, 2018, BIOMED PHARMACOTHER, V103, P490, DOI 10.1016/j.biopha.2018.04.074
   Ciccone L, 2023, PHARMACEUTICALS-BASE, V16, DOI 10.3390/ph16071036
   Clifford MN, 2000, J SCI FOOD AGR, V80, P1118, DOI [10.1002/(SICI)1097-0010(20000515)80:7<1118::AID-JSFA570>3.0.CO;2-9, 10.1002/(SICI)1097-0010(20000515)80:7<1063::AID-JSFA605>3.0.CO;2-Q]
   Colombo E, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/247145
   Costantini S, 2014, MOLECULES, V19, P8644, DOI 10.3390/molecules19068644
   Cronin P, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051655
   Cui JH, 2021, CURR MED CHEM, V28, P3622, DOI 10.2174/0929867327999200917150939
   Deepak Jeevika Chandrasekhar, 2018, J Int Acad Periodontol, V20, P110
   Deswal H., 2016, Innovare J. Med. Sci, V4, P15
   Di Daniele N, 2017, ONCOTARGET, V8, P8947, DOI 10.18632/oncotarget.13553
   DiSilvestro RA, 2009, PHYTOTHER RES, V23, P1123, DOI 10.1002/ptr.2759
   Elkarkhy Y., 2022, Al-Azhar J. Dent. Sci, V25, P359, DOI [10.21608/ajdsm.2021.88470.1218, DOI 10.21608/AJDSM.2021.88470.1218]
   Esmaillzadeh A, 2004, J MED FOOD, V7, P305, DOI 10.1089/1096620041938623
   Essa MM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0120964
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Farha AK, 2020, FOOD BIOSCI, V38, DOI 10.1016/j.fbio.2020.100751
   Fischer UA, 2011, FOOD CHEM, V127, P807, DOI 10.1016/j.foodchem.2010.12.156
   Fournier DB, 2000, J CELL BIOCHEM, P97
   Fraga-Corral M, 2021, FOODS, V10, DOI 10.3390/foods10020251
   García-Montero C, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020699
   Gawor JP, 2023, FRONT VET SCI, V10, DOI 10.3389/fvets.2023.1241197
   Ghaemi F, 2023, PHYTOTHER RES, V37, P4429, DOI 10.1002/ptr.7952
   Ghalayani Parichehr, 2013, J Res Pharm Pract, V2, P88, DOI 10.4103/2279-042X.117389
   Gheflati A, 2019, PHYTOTHER RES, V33, P1277, DOI 10.1002/ptr.6322
   Giamogante F, 2018, BIOCHIMIE, V147, P122, DOI 10.1016/j.biochi.2018.01.008
   Gianfredi V, 2018, INT J FOOD SCI NUTR, V69, P904, DOI 10.1080/09637486.2018.1446917
   Gullón P, 2020, MOLECULES, V25, DOI 10.3390/molecules25122859
   Halliwell B, 2000, FREE RADICAL RES, V33, P819, DOI 10.1080/10715760000301341
   Hashemi MS, 2021, COMPLEMENT MED RES, V28, P226, DOI 10.1159/000510986
   Hasnaoui N, 2014, FOOD CHEM, V160, P196, DOI 10.1016/j.foodchem.2014.03.089
   Holoch PA, 2011, J ENDOUROL, V25, P1903, DOI 10.1089/end.2011.0130
   Hong MY, 2008, J NUTR BIOCHEM, V19, P848, DOI 10.1016/j.jnutbio.2007.11.006
   Hosseini B, 2016, COMPLEMENT THER CLIN, V22, P44, DOI 10.1016/j.ctcp.2015.12.003
   Hou C, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201800773
   Howell AB, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/606212
   Huang THW, 2005, TOXICOL APPL PHARM, V207, P160, DOI 10.1016/j.taap.2004.12.009
   Husari Ahmad, 2014, BMC Res Notes, V7, P664, DOI 10.1186/1756-0500-7-664
   Imperatori F, 2019, NAT PROD RES, V33, P3465, DOI 10.1080/14786419.2018.1481841
   ISTAT, Coltivazioni Legnose Fruttifere
   James P, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008676.pub2
   Jourdes M., 2012, Handbook of Analysis of Active Compounds in Functional Foods, V1st ed.
   Kandra L, 2004, BIOCHEM BIOPH RES CO, V319, P1265, DOI 10.1016/j.bbrc.2004.05.122
   Kasimsetty SG, 2010, J AGR FOOD CHEM, V58, P2180, DOI 10.1021/jf903762h
   Katzke VA, 2015, CANCER J, V21, P104, DOI 10.1097/PPO.0000000000000101
   Kazemi M, 2016, FOOD CHEM, V206, P156, DOI 10.1016/j.foodchem.2016.03.017
   Khan N, 2007, CANCER RES, V67, P3475, DOI 10.1158/0008-5472.CAN-06-3941
   Khan N, 2007, CARCINOGENESIS, V28, P163, DOI 10.1093/carcin/bgl145
   Khanbabaee K, 2001, NAT PROD REP, V18, P641, DOI 10.1039/b101061l
   Khwairakpam AD, 2018, PHARMACOL RES, V133, P53, DOI 10.1016/j.phrs.2018.04.021
   Kim YE, 2017, NEUROPHARMACOLOGY, V117, P21, DOI 10.1016/j.neuropharm.2017.01.025
   Koh KH, 2011, J MICROBIOL IMMUNOL, V44, P144, DOI 10.1016/j.jmii.2009.10.001
   Kohno H, 2004, CANCER SCI, V95, P481, DOI 10.1111/j.1349-7006.2004.tb03236.x
   Kojadinovic MI, 2017, J SCI FOOD AGR, V97, P1798, DOI 10.1002/jsfa.7977
   Koren-Gluzer M, 2011, ATHEROSCLEROSIS, V219, P510, DOI 10.1016/j.atherosclerosis.2011.07.119
   Kote S, 2011, ANC SCI LIFE, V31, P49
   Laurindo LF, 2022, NUTRIENTS, V14, DOI 10.3390/nu14081665
   Lee CJ, 2010, FOOD CHEM, V118, P315, DOI 10.1016/j.foodchem.2009.04.123
   Lee ST, 2012, PROTEOMICS, V12, P3251, DOI 10.1002/pmic.201200084
   Li HM, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms242417538
   Li YL, 2016, BIOMED PHARMACOTHER, V80, P227, DOI 10.1016/j.biopha.2016.03.023
   Li YH, 2005, J ETHNOPHARMACOL, V99, P239, DOI 10.1016/j.jep.2005.02.030
   Liu YQ, 2018, J SEP SCI, V41, P3022, DOI 10.1002/jssc.201800480
   LOPEZFERBER M, 1992, J INVERTEBR PATHOL, V59, P264, DOI 10.1016/0022-2011(92)90131-M
   Loren DJ, 2005, PEDIATR RES, V57, P858, DOI 10.1203/01.PDR.0000157722.07810.15
   Lucarini M, 2021, MOLECULES, V26, DOI 10.3390/molecules26216338
   Ma Y, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000011678
   Malhotra J, 2016, EUR RESPIR J, V48, P889, DOI 10.1183/13993003.00359-2016
   Man GW, 2023, INNOV FOOD SCI EMERG, V84, DOI 10.1016/j.ifset.2023.103291
   Mandal A, 2015, MOLECULES, V20, P22315, DOI 10.3390/molecules201219853
   Marín M, 2013, J ETHNOPHARMACOL, V150, P925, DOI 10.1016/j.jep.2013.09.030
   Marrone G, 2024, LIFE-BASEL, V14, DOI 10.3390/life14010049
   Marrone G, 2024, NUTRIENTS, V16, DOI 10.3390/nu16010045
   Marrone G, 2021, NUTRIENTS, V13, DOI 10.3390/nu13030817
   Marya C, 2022, J INDIAN ASSOC PUB H, V20, P427, DOI 10.4103/jiaphd.jiaphd_193_21
   Mastrogiovanni F, 2021, NAT PROD RES, V35, P1696, DOI 10.1080/14786419.2019.1627350
   Mastrogiovanni F, 2020, NAT PROD RES, V34, P1465, DOI 10.1080/14786419.2018.1508149
   Matsushita M, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21041447
   McDowell C, 2023, StatPearls
   Mehdi A, 2022, FOODS, V11, DOI 10.3390/foods11172570
   Menezes Silvana M. S., 2006, Journal of Herbal Pharmacotherapy, V6, P79, DOI [10.1300/J157v06n02_07, 10.1080/J157v06n02_07]
   Narayan T., 2014, IOSR J. Dent. Med. Sci, V13, P29, DOI [10.9790/0853-13842934, DOI 10.9790/0853-13842934]
   Narimatsu H, 2022, NUTRIENTS, V14, DOI 10.3390/nu14163329
   Negi PS, 2012, INT J FOOD MICROBIOL, V156, P7, DOI 10.1016/j.ijfoodmicro.2012.03.006
   Nema N., 2013, AM J PHYTOMEDICINE C, V1, P195
   Nguyen-Nielsen M, 2016, SEMIN NUCL MED, V46, P484, DOI 10.1053/j.semnuclmed.2016.07.002
   Noce A, 2022, EUR REV MED PHARMACO, V26, P5312, DOI 10.26355/eurrev_202208_29396
   Noce A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13041358
   Noce A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020630
   Nomura Yoshiaki, 2006, J Oral Sci, V48, P177, DOI 10.2334/josnusd.48.177
   Patel C, 2008, FOOD CHEM TOXICOL, V46, P2728, DOI 10.1016/j.fct.2008.04.035
   Peng JF, 2023, PHARM BIOL, V61, P963, DOI 10.1080/13880209.2023.2224403
   Pereira J., 2005, J. Dent. Sci, V20, P262
   Pereira J.V., 2001, Periodontics Rev, V12, P57
   Pogribny IP, 2013, ADV EXP MED BIOL, V754, P215, DOI 10.1007/978-1-4419-9967-2_11
   Prasad Divyashree, 2014, J Indian Soc Periodontol, V18, P428, DOI 10.4103/0972-124X.138678
   Quave CL, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0028737
   Romani A, 2020, FRONT NUTR, V7, DOI 10.3389/fnut.2020.00120
   Salgado Alexandre Daher Yunes, 2006, J. Appl. Oral Sci., V14, P162, DOI 10.1590/S1678-77572006000300003
   Sastravaha Grindwit, 2005, J Int Acad Periodontol, V7, P70
   Scaioli E, 2019, TRIALS, V20, DOI 10.1186/s13063-019-3321-8
   SCANNAPIECO FA, 1993, CRIT REV ORAL BIOL M, V4, P301, DOI 10.1177/10454411930040030701
   Seeram NP, 2005, J NUTR BIOCHEM, V16, P360, DOI 10.1016/j.jnutbio.2005.01.006
   Shaila Mulki, 2013, J Indian Soc Periodontol, V17, P42, DOI 10.4103/0972-124X.107473
   Sharifi-Rad J, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/3848084
   Sharma A, 2009, INDIAN J PHARM SCI, V71, P136, DOI 10.4103/0250-474X.54279
   Sharma P, 2017, MOLECULES, V22, DOI 10.3390/molecules22010177
   Sharma U, 2004, J Indian Soc Pedod Prev Dent, V22, P38
   Shirode AB, 2014, MOL CARCINOGEN, V53, P458, DOI 10.1002/mc.21995
   Singh B, 2019, INT J FOOD SCI TECH, V54, P959, DOI 10.1111/ijfs.13964
   Singh J, 2023, ACS OMEGA, V8, P35452, DOI 10.1021/acsomega.3c02586
   Smaoui S, 2019, MEAT SCI, V158, DOI 10.1016/j.meatsci.2019.107914
   Sohrab G, 2019, CLIN NUTR ESPEN, V29, P30, DOI 10.1016/j.clnesp.2018.11.013
   Solakyildirim Kemal, 2019, HACETTEPE JOURNAL OF BIOLOGY AND CHEMISTRY, V47, P267, DOI 10.15671/hjbc.626949
   Somu C Ashwini, 2012, J Ayurveda Integr Med, V3, P85, DOI 10.4103/0975-9476.96525
   Subash Selvaraju, 2014, J Tradit Complement Med, V4, P232, DOI 10.4103/2225-4110.139107
   Subkorn P, 2021, PEERJ, V9, DOI 10.7717/peerj.12303
   Tamborlin L, 2020, FOOD SCI NUTR, V8, P5483, DOI 10.1002/fsn3.1831
   Tavassoli-Hojjati Sara, 2014, J Dent (Tehran), V11, P225
   Tetè S, 2012, INT J IMMUNOPATH PH, V25, P573, DOI 10.1177/039463201202500303
   Thanikachalam K, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010164
   Tiffon C, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19113425
   Torre LA, 2015, CA-CANCER J CLIN, V65, P87, DOI 10.3322/caac.21262
   Tracy CR, 2014, UROLITHIASIS, V42, P401, DOI 10.1007/s00240-014-0686-8
   Trigo JP, 2020, CRIT REV FOOD SCI, V60, P1388, DOI 10.1080/10408398.2019.1572588
   Tugcu V, 2008, J ENDOUROL, V22, P2723, DOI 10.1089/end.2008.0357
   Turati F, 2015, BRIT J NUTR, V113, pS102, DOI 10.1017/S0007114515000148
   Umeda M, 2003, J PERIODONTOL, V74, P129, DOI 10.1902/jop.2003.74.1.129
   Vahabi S, 2011, J MED PLANTS RES, V5, P4870
   VANDEROUDERAA FJG, 1991, J CLIN PERIODONTOL, V18, P447
   Vasconcelos LCD, 2003, MYCOSES, V46, P192, DOI 10.1046/j.1439-0507.2003.00884.x
   Velagapudi R, 2016, EUR J NUTR, V55, P1653, DOI 10.1007/s00394-015-0984-0
   Vora AK, 2015, J ADV PHARM TECHNOL, V6, P75, DOI 10.4103/2231-4040.154542
   Vucic V, 2019, CURR PHARM DESIGN, V25, P1817, DOI 10.2174/1381612825666190708183941
   Wang C, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081791
   Wang Lixue, 2023, Oxidative Medicine and Cellular Longevity, V2023, P6480848, DOI 10.1155/2023/6480848
   Wang YR, 2014, PROSTATE, V74, P497, DOI 10.1002/pros.22769
   Weitz J, 2005, LANCET, V365, P153, DOI 10.1016/S0140-6736(19)32319-0
   Xie J, 2023, ENVIRON TECHNOL INNO, V31, DOI 10.1016/j.eti.2023.103147
   Xu YF, 2017, FOODBORNE PATHOG DIS, V14, P282, DOI 10.1089/fpd.2016.2226
   Yamada H, 2018, MOLECULES, V23, DOI 10.3390/molecules23081901
   Yin YT, 2024, CRIT REV FOOD SCI, V64, P10009, DOI 10.1080/10408398.2023.2219763
   Yisimayili Z, 2019, J CHROMATOGR A, V1604, DOI 10.1016/j.chroma.2019.460472
   Yoshida T, 2010, INT J MOL SCI, V11, P79, DOI 10.3390/ijms11010079
   Zarfeshany Aida, 2014, Adv Biomed Res, V3, P100, DOI 10.4103/2277-9175.129371
   Zhao RQ, 2019, FOOD FUNCT, V10, P8273, DOI [10.1039/c9fo02077b, 10.1039/C9FO02077B]
NR 181
TC 8
Z9 8
U1 2
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3417
J9 APPL SCI-BASEL
JI Appl. Sci.-Basel
PD FEB
PY 2024
VL 14
IS 4
AR 1570
DI 10.3390/app14041570
PG 29
WC Chemistry, Multidisciplinary; Engineering, Multidisciplinary; Materials
   Science, Multidisciplinary; Physics, Applied
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering; Materials Science; Physics
GA JI5G5
UT WOS:001172543500001
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Robberecht, H
   Hermans, N
AF Robberecht, Harry
   Hermans, Nina
TI Biomarkers of Metabolic Syndrome: Biochemical Background and Clinical
   Significance
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Review
ID C-REACTIVE PROTEIN; ACID-BINDING PROTEIN; GAMMA-GLUTAMYL-TRANSFERASE;
   NONALCOHOLIC FATTY LIVER; CORONARY-ARTERY-DISEASE; SERUM URIC-ACID;
   NECROSIS-FACTOR-ALPHA; MONOCYTE CHEMOATTRACTANT PROTEIN-1;
   CARDIOVASCULAR RISK-FACTORS; EPITHELIUM-DERIVED FACTOR
AB Biomarkers of the metabolic syndrome are divided into four subgroups. Although dividing them in groups has some limitations, it can be used to draw some conclusions. In a first part, the dyslipidemias and markers of oxidative stress are discussed, while inflammatory markers and cardiometabolic biomarkers are reviewed in a second part. For most of them, the biochemical background and clinical significance are discussed, although here also a well-cut separation cannot always be made. Altered levels cannot always be claimed as the cause, risk, or consequence of the syndrome. Several factors are interrelated to each other and act in a concerted, antagonistic, synergistic, or modulating way. Most important conclusions are summarized at the end of every reviewed subgroup. Genetic biomarkers or influences of various food components on concentration levels are not included in this review article.
C1 [Robberecht, Harry; Hermans, Nina] Univ Antwerp, Dept Pharmaceut Sci, NatuRA Nat Prod & Food Res & Anal, Univ Pl 1, B-2610 Antwerp, Belgium.
C3 University of Antwerp
RP Robberecht, H (corresponding author), Univ Antwerp, Dept Pharmaceut Sci, NatuRA Nat Prod & Food Res & Anal, Univ Pl 1, B-2610 Antwerp, Belgium.
EM labrom@ua.ac.be
RI Hermans, Nina/A-5244-2017
OI Hermans, Nina/0000-0003-3946-7313
CR Abdou M, 2013, J DIABETES RES CLIN
   Abdul-Ghani MA, 2008, DIABETES CARE, V31, P1650, DOI 10.2337/dc08-0225
   Abdullah A, 2012, INT J ENDOCRINOL, V2012, DOI 10.1155/2012/420792
   Abdullah AR, 2009, METAB SYNDR RELAT D, V7, P17, DOI 10.1089/met.2008.0045
   Abraham SB, 2013, OBESITY, V21, pE105, DOI 10.1002/oby.20083
   Abu-Farha M, 2014, CARDIOVASC DIABETOL, V13, DOI 10.1186/1475-2840-13-76
   Adamska A, 2014, ENDOCRINE, V45, P422, DOI 10.1007/s12020-013-0025-9
   Afsaneh Bakhtiary Afsaneh Bakhtiary, 2010, Journal of Family and Reproductive Health, V4, P95
   Ahima RS, 2000, ANNU REV PHYSIOL, V62, P413, DOI 10.1146/annurev.physiol.62.1.413
   Ahirwar AK, 2014, DIABETES METAB SYND, V8, P152, DOI 10.1016/j.dsx.2014.04.035
   Ahlström T, 2009, CLIN ENDOCRINOL, V71, P673, DOI 10.1111/j.1365-2265.2009.03558.x
   AHUJA SK, 1994, IMMUNOL TODAY, V15, P281, DOI 10.1016/0167-5699(94)90008-6
   Aizawa K, 2009, DIABETES VASC DIS RE, V6, P181, DOI 10.1177/1479164109336375
   Akinci B, 2011, DIABETES RES CLIN PR, V91, P26, DOI 10.1016/j.diabres.2010.09.028
   Al-Daghri NM, 2010, EUR J CLIN INVEST, V40, P1063, DOI 10.1111/j.1365-2362.2010.02341.x
   Al-Hamodi Z, 2012, J BIOMED BIOTECHNOL, DOI 10.1155/2012/234937
   Al-Hamodi Z, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-23
   Al-Hamodi ZH, 2012, J CLIN BIOCHEM NUTR, V50, P184, DOI 10.3164/jcbn.11-48
   AL-Suhaimi EA, 2013, EUR J MED RES, V18, DOI 10.1186/2047-783X-18-12
   Alam Uazman, 2014, Handb Clin Neurol, V126, P211, DOI 10.1016/B978-0-444-53480-4.00015-1
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alessi MC, 2006, ARTERIOSCL THROM VAS, V26, P2200, DOI 10.1161/01.ATV.0000242905.41404.68
   Alikasifoglu Ayfer, 2009, J Clin Res Pediatr Endocrinol, V1, P233, DOI 10.4274/jcrpe.v1i5.233
   Anagnostis P, 2009, J CLIN ENDOCR METAB, V94, P2692, DOI 10.1210/jc.2009-0370
   Ando K, 2009, FREE RADICAL BIO MED, V47, P213, DOI 10.1016/j.freeradbiomed.2009.04.030
   André P, 2007, DIABETES CARE, V30, P2355, DOI 10.2337/dc07-0440
   Andrews NC, 1998, BLOOD, V92, P1845, DOI 10.1182/blood.V92.6.1845.418k35_1845_1851
   Angelico F, 2006, DIABETOLOGIA, V49, P1169, DOI 10.1007/s00125-006-0222-7
   Angelopoulos TJ, 2009, J NUTR, V139, pS1242, DOI 10.3945/jn.108.098194
   Angelova P., 2014, Open J. Endocr. Metab. Dis, V4, P35, DOI [10.4236/ojemd.2014.42004, DOI 10.4236/OJEMD.2014.42004, DOI 10.4236/ojemd.2014.42004]
   Angulo P, 2002, NEW ENGL J MED, V346, P1221, DOI 10.1038/nrdp.2015.80
   Angulo P, 2004, J HEPATOL, V41, P943, DOI 10.1016/j.jhep.2004.08.020
   [Anonymous], 2011, ARISTOTLE U MED J
   [Anonymous], BENI SUEF U J BASIC
   Anuradha S, 2010, METABOLISM, V59, P774, DOI 10.1016/j.metabol.2009.09.022
   Arita Y, 1999, BIOCHEM BIOPH RES CO, V257, P79, DOI 10.1006/bbrc.1999.0255
   ARMSTRONG D, 1994, ADV EXP MED BIOL, V366, P43
   Armutcu F, 2008, CLIN CHEM LAB MED, V46, P785, DOI 10.1515/CCLM.2008.166
   Arnaud J, 2012, NUTR METAB CARDIOVAS, V22, P517, DOI 10.1016/j.numecd.2010.09.005
   Arner E, 2010, NEW ENGL J MED, V362, P1151, DOI 10.1056/NEJMc0910718
   Aro A, 2003, NUTR METAB CARDIOVAS, V13, P253, DOI 10.1016/S0939-4753(03)80028-5
   Artwohl M, 2002, INT J OBESITY, V26, P577, DOI 10.1038/sj.ijo.0801947
   Arver S, 2008, J MENS HEALTH, V5, pS7, DOI 10.1016/j.jomh.2008.03.009
   Asakawa A, 2003, GUT, V52, P947, DOI 10.1136/gut.52.7.947
   Asano H, 2010, DIABETOLOGIA, V53, P234, DOI 10.1007/s00125-009-1517-2
   Ascaso J, 2007, AM J CARDIOVASC DRUG, V7, P39, DOI 10.2165/00129784-200707010-00004
   Asefy Zahra, 2014, Pak J Biol Sci, V17, P582
   Åsvold BO, 2007, EUR J ENDOCRINOL, V156, P707, DOI 10.1530/eje.1.02333e
   Atkinson AJ, 2001, CLIN PHARMACOL THER, V69, P89, DOI 10.1067/mcp.2000.113989
   Auguet T, 2011, BMC MED GENET, V12, DOI 10.1186/1471-2350-12-60
   Avignon A, 1999, INT J OBESITY, V23, P512, DOI 10.1038/sj.ijo.0800864
   Ayina CNA, 2014, ANN ENDOCRINOL-PARIS, V75, P165, DOI 10.1016/j.ando.2014.05.006
   Bae Yun-Jung, 2013, Clin Nutr Res, V2, P91, DOI 10.7762/cnr.2013.2.2.91
   Baessler A, 2014, NUTR DIABETES, V4, DOI 10.1038/nutd.2014.3
   Bagheri R, 2010, AM J CARDIOL, V106, P1118, DOI 10.1016/j.amjcard.2010.06.028
   Baldwin W, 2011, DIABETES, V60, P1258, DOI 10.2337/db10-0916
   Ballantyne CM, 2004, CIRCULATION, V109, P837, DOI 10.1161/01.CIR.0000116763.91992.F1
   Baltaci Davut, 2013, Med Glas (Zenica), V10, P203
   Baltaci D, 2012, TURK J MED SCI, V42, P802, DOI 10.3906/sag-1105-6
   Bandurska-Stankiewicz E., 2013, Thyroid. Res, V6, pA5, DOI [10.1186/1756-6614-6-S2-A5, DOI 10.1186/1756-6614-6-S2-A5]
   Banu S, 2011, CNS NEUROL DISORD-DR, V10, P921, DOI 10.2174/187152711799219271
   Bao YY, 2011, ARCH MED SCI, V7, P247, DOI 10.5114/aoms.2011.22075
   Baratta Mario, 2002, Med Sci Monit, V8, pRA282
   Barazzoni R, 2014, NUTR CLIN PRACT, V29, P215, DOI 10.1177/0884533613516168
   Barceló A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0084362
   Basoglu OK, 2011, ANN THORAC MED, V6, P120, DOI 10.4103/1817-1737.82440
   Bassuk SS, 2004, CURR PROB CARDIOLOGY, V29, P439, DOI 10.1016/j.cpcardiol.2004.03.004
   Batista CMDS, 2007, DIABETES, V56, P1655, DOI 10.2337/db06-1506
   BAXA CA, 1989, BIOCHEMISTRY-US, V28, P8683, DOI 10.1021/bi00448a003
   Becker AE, 1999, NEW ENGL J MED, V340, P1092, DOI 10.1056/NEJM199904083401407
   Belfiore F, 1998, MOL GENET METAB, V63, P134, DOI 10.1006/mgme.1997.2658
   Belfki H, 2011, EXP MOL PATHOL, V91, P622, DOI 10.1016/j.yexmp.2011.06.007
   Bellia Chiara, 2007, Ther Clin Risk Manag, V3, P999
   Beltowski Jerzy, 2003, Med Sci Monit, V9, pRA55
   Berenson GS, 1998, NEW ENGL J MED, V338, P1650, DOI 10.1056/NEJM199806043382302
   Berg AH, 2002, TRENDS ENDOCRIN MET, V13, P84, DOI 10.1016/S1043-2760(01)00524-0
   Berliner JA, 2005, NEW ENGL J MED, V353, P9, DOI 10.1056/NEJMp058118
   BERMAN M, 1978, J LIPID RES, V19, P38
   Bermúdez V, 2013, J DIABETES RES, V2013, DOI 10.1155/2013/416451
   Bernabé J, 2013, J FUNCT FOODS, V5, P1031, DOI 10.1016/j.jff.2013.02.003
   Bernardi S, 2014, MOL CELL ENDOCRINOL, V394, P13, DOI 10.1016/j.mce.2014.06.004
   Beumer W, 2012, PSYCHONEUROENDOCRINO, V37, P1901, DOI 10.1016/j.psyneuen.2012.04.001
   Bjorge T, 2010, CANCER EPIDEM BIOMAR, V19, P1737, DOI 10.1158/1055-9965.EPI-10-0230
   Black S, 2004, J BIOL CHEM, V279, P48487, DOI 10.1074/jbc.R400025200
   Blake GJ, 2003, CIRCULATION, V108, P2993, DOI 10.1161/01.CIR.0000104566.10178.AF
   Blankenberg S, 2003, CIRCULATION, V108, P2453, DOI 10.1161/01.CIR.0000099509.76044.A2
   Blaslov K, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/535906
   Bloomgarden ZT, 2004, DIABETES CARE, V27, P3009, DOI 10.2337/diacare.27.12.3009
   Blyth KG, 2007, EUR RESPIR J, V29, P737, DOI 10.1183/09031936.00095606
   Bo S, 2009, DIABETES-METAB RES, V25, P76, DOI 10.1002/dmrr.910
   Bobbert T, 2013, DIABETES CARE, V36, P145, DOI 10.2337/dc12-0703
   BONIFATI C, 1994, CLIN EXP DERMATOL, V19, P383, DOI 10.1111/j.1365-2230.1994.tb02687.x
   Bonora E, 2000, DIABETES CARE, V23, P57, DOI 10.2337/diacare.23.1.57
   Bonora E, 1998, DIABETES, V47, P1643, DOI 10.2337/diabetes.47.10.1643
   Boring L, 1997, J CLIN INVEST, V100, P2552, DOI 10.1172/JCI119798
   Boucher J, 2005, ENDOCRINOLOGY, V146, P1764, DOI 10.1210/en.2004-1427
   Bouck N, 2002, TRENDS MOL MED, V8, P330, DOI 10.1016/S1471-4914(02)02362-6
   Boumaiza I, 2012, GENET TEST MOL BIOMA, V16, P1356, DOI 10.1089/gtmb.2012.0156
   Boyraz M, 2013, BIOMARK MED, V7, P737, DOI 10.2217/bmm.13.13
   Boyraz M, 2013, BIOMARK MED, V7, P423, DOI [10.2217/bmm.13.14, 10.2217/BMM.13.14]
   Bozaoglu K, 2007, ENDOCRINOLOGY, V148, P4687, DOI 10.1210/en.2007-0175
   Bozaoglu K, 2009, J CLIN ENDOCR METAB, V94, P3085, DOI 10.1210/jc.2008-1833
   Bozzini C, 2005, DIABETES CARE, V28, P2061, DOI 10.2337/diacare.28.8.2061
   Bradley RD, 2014, ATHEROSCLEROSIS, V233, P387, DOI 10.1016/j.atherosclerosis.2014.01.010
   Bremer AA, 2013, J OBES, V2013, DOI 10.1155/2013/393192
   Brenner H, 1997, PREV MED, V26, P305, DOI 10.1006/pmed.1997.0144
   Briet M, 2011, CURR HYPERTENS REP, V13, P163, DOI 10.1007/s11906-011-0182-2
   Brigelius-Flohé R, 1999, FREE RADICAL BIO MED, V27, P951, DOI 10.1016/S0891-5849(99)00173-2
   Broglio F, 2002, J PEDIATR ENDOCR MET, V15, P1219
   Brown WV, 2008, J CLIN LIPIDOL, V2, P335, DOI 10.1016/j.jacl.2008.08.444
   Browning JD, 2004, HEPATOLOGY, V40, P1387, DOI 10.1002/hep.20466
   Browning LM, 2004, INT J OBESITY, V28, P1004, DOI 10.1038/sj.ijo.0802711
   Budak N, 2009, METAB SYNDR RELAT D, V7, P357, DOI 10.1089/met.2008.0037
   BURKE GL, 1986, METABOLISM, V35, P441, DOI 10.1016/0026-0495(86)90135-6
   Burrows RA, 2011, PEDIATR DIABETES, V12, P212, DOI 10.1111/j.1399-5448.2010.00685.x
   Cabre A., 2007, ATHEROSCLEROSIS, V195, pe150, DOI DOI 10.1016/J.ATHEROSCLEROSIS.2007.04.045
   Cabré A, 2008, J LIPID RES, V49, P1746, DOI 10.1194/jlr.M800102-JLR200
   Cabré A, 2010, J LIPID RES, V51, P1173, DOI 10.1194/jlr.M900066
   Caidahl K, 2010, ARTERIOSCL THROM VAS, V30, P1684, DOI 10.1161/ATVBAHA.110.208843
   CAMPFIELD LA, 1995, SCIENCE, V269, P546, DOI 10.1126/science.7624778
   Cao HM, 2014, J ENDOCRINOL, V220, pT47, DOI 10.1530/JOE-13-0339
   Capuzzi D.M., 2007, Clinical Diabetes, V25, P16, DOI DOI 10.2337/DIACLIN.25.1.16
   Carmel Ralph, 2003, Hematology Am Soc Hematol Educ Program, P62
   Carstensen M, 2013, EUR J CLIN INVEST, V43, P350, DOI 10.1111/eci.12052
   Casanueva Felipe F, 2002, Rev Endocr Metab Disord, V3, P325, DOI 10.1023/A:1020901624103
   Catalán V, 2011, NUTR METAB CARDIOVAS, V21, P245, DOI 10.1016/j.numecd.2009.09.008
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Chae JS, 2011, ATHEROSCLEROSIS, V218, P499, DOI 10.1016/j.atherosclerosis.2011.06.036
   Chait A, 2005, J LIPID RES, V46, P389, DOI 10.1194/jlr.R400017-JLR200
   CHAIT A, 1993, AM J MED, V94, P350, DOI 10.1016/0002-9343(93)90144-E
   Chambless LE, 1997, AM J EPIDEMIOL, V146, P483, DOI 10.1093/oxfordjournals.aje.a009302
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Chang YH, 2011, DIABETES-METAB RES, V27, P515, DOI 10.1002/dmrr.1201
   Chedraui P, 2014, MATURITAS, V79, P86, DOI 10.1016/j.maturitas.2014.06.008
   Chen AR, 2010, CLIN INVEST MED, V33, pE290, DOI 10.25011/cim.v33i5.14354
   Chen BH, 2009, DIABETES CARE, V32, P329, DOI 10.2337/dc08-1625
   Chen C, 2010, J CLIN ENDOCR METAB, V95, P5074, DOI 10.1210/jc.2010-0727
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Chen J, 2007, NEPHROL DIAL TRANSPL, V22, P1100, DOI 10.1093/ndt/gfl759
   Chen SJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0045693
   Chen XY, 2013, J PEDIATR ENDOCR MET, V26, P855, DOI 10.1515/jpem-2012-0326
   Chen YJ, 2008, ARCH DERMATOL, V144, P1571, DOI 10.1001/archderm.144.12.1571
   Cheng SP, 2014, MEDIAT INFLAMM, V2014, DOI 10.1155/2014/709024
   Chien KL, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-33
   Chiou WK, 2010, J EPIDEMIOL, V20, P219, DOI 10.2188/jea.JE20090078
   Chitturi S, 2002, HEPATOLOGY, V36, P403, DOI 10.1053/jhep.2002.34738
   Chiu FH, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-40
   Choi JW, 2003, ANN CLIN LAB SCI, V33, P257
   Choi KM, 2007, EUR J ENDOCRINOL, V157, P437, DOI 10.1530/EJE-07-0127
   Choi KM, 2007, DIABETES RES CLIN PR, V75, P235, DOI 10.1016/j.diabres.2006.06.019
   Choi KM, 2009, CLIN ENDOCRINOL, V70, P569, DOI 10.1111/j.1365-2265.2008.03374.x
   Choi KM, 2005, METABOLISM, V54, P1510, DOI 10.1016/j.metabol.2005.05.018
   Choi KM, 2004, CLIN ENDOCRINOL, V61, P75, DOI 10.1111/j.1365-2265.2004.02063.x
   Choi KM, 2011, AM J CLIN NUTR, V93, P19, DOI 10.3945/ajcn.2010.29667
   Choi SH, 2013, NUTR METAB CARDIOVAS, V23, P31, DOI 10.1016/j.numecd.2011.03.001
   Choi SH, 2011, CLIN ENDOCRINOL, V75, P628, DOI 10.1111/j.1365-2265.2011.04095.x
   Chow WS, 2013, ARTERIOSCL THROM VAS, V33, P2454, DOI 10.1161/ATVBAHA.113.301599
   Chow WS, 2013, J AM HEART ASSOC, V2, DOI 10.1161/JAHA.112.004176
   Chu SH, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034710
   Chugh Kiran, 2012, Indian J Endocrinol Metab, V16, P958, DOI 10.4103/2230-8210.102999
   Ciarla S, 2014, ARCH PHYSIOL BIOCHEM, V120, P119, DOI 10.3109/13813455.2014.924145
   Civelek S, 2015, J CLIN LAB ANAL, V29, P184, DOI 10.1002/jcla.21748
   Clearfield Michael B, 2005, J Am Osteopath Assoc, V105, P409
   Cohen B, 1996, SCIENCE, V274, P1185, DOI 10.1126/science.274.5290.1185
   COHEN HJ, 1985, AM J CLIN NUTR, V41, P735, DOI 10.1093/ajcn/41.4.735
   COLEMAN MP, 1992, ATHEROSCLEROSIS, V92, P177, DOI 10.1016/0021-9150(92)90276-M
   Coll B, 2008, ATHEROSCLEROSIS, V199, P147, DOI 10.1016/j.atherosclerosis.2007.09.032
   Coll E, 2000, AM J KIDNEY DIS, V36, P29, DOI 10.1053/ajkd.2000.8237
   Collantes RS, 2006, PANMINERVA MED, V48, P41
   Conen D, 2009, CIRCULATION, V120, P1041, DOI 10.1161/CIRCULATIONAHA.109.863092
   Considine RV, 1996, NEW ENGL J MED, V334, P292, DOI 10.1056/NEJM199602013340503
   Coppari R, 2012, NAT REV DRUG DISCOV, V11, P692, DOI 10.1038/nrd3757
   Corripio R, 2010, EUR J ENDOCRINOL, V163, P887, DOI 10.1530/EJE-10-0408
   Cortese C, 2001, Public Health Nutr, V4, P493
   Costandi J, 2011, CIRC RES, V108, P727, DOI 10.1161/CIRCRESAHA.110.238949
   CREMER P, 1994, EUR J CLIN INVEST, V24, P444, DOI 10.1111/j.1365-2362.1994.tb02373.x
   CREMER P, 1988, KLIN WOCHENSCHR, V66, P42
   CROOK MA, 1993, DIABETES CARE, V16, P57, DOI 10.2337/diacare.16.1.57
   Czernichow S, 2009, AM J CLIN NUTR, V90, P329, DOI 10.3945/ajcn.2009.27635
   Dabrowska AM, 2013, CURR ISSUES PHARM ME, V26, P309
   Dai XY, 2013, EUR J EPIDEMIOL, V28, P669, DOI 10.1007/s10654-013-9829-4
   Dallmeier D, 2012, DIABETOL METAB SYNDR, V4, DOI 10.1186/1758-5996-4-28
   Damevska K, 2013, J DTSCH DERMATOL GES, V11, P1169, DOI 10.1111/ddg.12193
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   Danesh J, 2000, CIRCULATION, V102, P1082, DOI 10.1161/01.CIR.102.10.1082
   Das UN, 2002, NUTRITION, V18, P430, DOI 10.1016/S0899-9007(01)00747-X
   Das UN, 2001, NUTRITION, V17, P953, DOI 10.1016/S0899-9007(01)00672-4
   de Ferranti S, 2008, CLIN CHEM, V54, P945, DOI 10.1373/clinchem.2007.100156
   Garduño-Garcia JD, 2010, EUR J ENDOCRINOL, V163, P273, DOI 10.1530/EJE-10-0312
   de Jongh RT, 2004, DIABETES, V53, P2873, DOI 10.2337/diabetes.53.11.2873
   de la Sierra A, 2010, J HUM HYPERTENS, V24, P373, DOI 10.1038/jhh.2009.91
   de Luis DA, 2013, DIABETES-METAB RES, V29, P576, DOI 10.1002/dmrr.2430
   de Oliveira EP, 2012, DIABETOL METAB SYNDR, V4, DOI 10.1186/1758-5996-4-12
   De Vriese C, 2008, INT J BIOCHEM CELL B, V40, P1420, DOI 10.1016/j.biocel.2007.04.020
   Deetman PE, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-166
   DEFRONZO RA, 1991, DIABETES CARE, V14, P173, DOI 10.2337/diacare.14.3.173
   DEFRONZO RA, 1979, AM J PHYSIOL, V237, pE214
   Degawa-Yamauchi M, 2003, J CLIN ENDOCR METAB, V88, P5452, DOI 10.1210/jc.2002-021808
   den Engelsen C, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-25
   Deng YF, 2010, ANN NY ACAD SCI, V1212, pE1, DOI 10.1111/j.1749-6632.2010.05875.x
   Devaraj S, 2003, CIRCULATION, V107, P398, DOI 10.1161/01.CIR.0000052617.91920.FD
   Devaraj S, 2008, ARTERIOSCL THROM VAS, V28, P1368, DOI 10.1161/ATVBAHA.108.163303
   Devaraj S, 2008, AM J CLIN PATHOL, V129, P815, DOI 10.1309/RN84K51B2JJY1Y0B
   Devaraj S, 2008, FREE RADICAL BIO MED, V44, P1203, DOI 10.1016/j.freeradbiomed.2007.12.018
   Devaraj S, 2009, CURR OPIN LIPIDOL, V20, P182, DOI 10.1097/MOL.0b013e32832ac03e
   Dharnidharka VR, 2002, AM J KIDNEY DIS, V40, P221, DOI 10.1053/ajkd.2002.34487
   Di Lorenzo C, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/782461
   Dierkes Jutta, 2005, Semin Vasc Med, V5, P124
   Do MS, 2006, YONSEI MED J, V47, P729, DOI 10.3349/ymj.2006.47.5.729
   Dong BK, 2011, INTERNAL MED, V50, P1093, DOI 10.2169/internalmedicine.50.5025
   Ferro FED, 2011, BIOL TRACE ELEM RES, V143, P787, DOI 10.1007/s12011-010-8940-6
   Dullaart RPF, 2013, OBESITY, V21, P361, DOI 10.1002/oby.20058
   Dupont DM, 2009, FRONT BIOSCI-LANDMRK, V14, P1337, DOI 10.2741/3312
   DURRINGTON PN, 1986, BRIT HEART J, V56, P206, DOI 10.1136/hrt.56.3.206
   Dutheil F, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-148
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Ekstedt M, 2006, HEPATOLOGY, V44, P865, DOI 10.1002/hep.21327
   El-Hadidi H, 2014, ARCH DERMATOL RES, V306, P239, DOI 10.1007/s00403-013-1414-x
   El-Shahhat N, 2011, EGYPT HEART J, V63, P131, DOI 10.1016/j.ehj.2011.08.024
   Elmasri H, 2009, FASEB J, V23, P3865, DOI 10.1096/fj.09-134882
   Elshaari F.A., 2013, INT J BIOL MED RES, V4, P3278
   Emdin M, 2005, CIRCULATION, V112, P2078, DOI 10.1161/CIRCULATIONAHA.105.571919
   Emilsson V, 1997, DIABETES, V46, P313, DOI 10.2337/diabetes.46.2.313
   Enhörning S, 2013, INT J OBESITY, V37, P598, DOI 10.1038/ijo.2012.88
   Enhörning S, 2011, J CLIN ENDOCR METAB, V96, pE1065, DOI 10.1210/jc.2010-2981
   Esmat S., 2010, J Am Sci, V6, P1374
   Esposito K, 2004, NUTR METAB CARDIOVAS, V14, P228, DOI 10.1016/S0939-4753(04)80048-6
   Esposito K, 2003, J CLIN ENDOCR METAB, V88, P1055, DOI 10.1210/jc.2002-021437
   Esteghamati A, 2014, J CARDIOL, V64, P290, DOI 10.1016/j.jjcc.2014.02.001
   Esteghamati A, 2012, J CARDIOVASC TRANSL, V5, P541, DOI 10.1007/s12265-012-9373-8
   Esteghamati A, 2011, CLIN INVEST MED, V34, pE131, DOI 10.25011/cim.v34i3.15185
   Esteghamati A, 2010, NUTR METAB, V7, DOI 10.1186/1743-7075-7-26
   Esteghamati A, 2009, DIABETES RES CLIN PR, V84, P279, DOI 10.1016/j.diabres.2009.03.005
   ETTEHADI P, 1994, CLIN EXP IMMUNOL, V96, P146, DOI 10.1111/j.1365-2249.1994.tb06244.x
   Everett BM, 2009, ATHEROSCLEROSIS, V202, P282, DOI 10.1016/j.atherosclerosis.2008.04.015
   FACCHINI F, 1991, JAMA-J AM MED ASSOC, V266, P3008, DOI 10.1001/jama.266.21.3008
   Farooqi IS, 2009, AM J CLIN NUTR, V89, p980S, DOI 10.3945/ajcn.2008.26788C
   Farooqi IS, 1999, NEW ENGL J MED, V341, P879, DOI 10.1056/NEJM199909163411204
   Fathi E., 2014, British Journal of Medicine and Medical Research, V4, P1701
   Fatima SS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057113
   Feng LG, 2009, PSYCHIAT RES, V168, P205, DOI 10.1016/j.psychres.2008.05.009
   Feng RN, 2014, DIABETES RES CLIN PR, V106, P88, DOI 10.1016/j.diabres.2014.07.026
   Fernández-Real JM, 2008, TRENDS ENDOCRIN MET, V19, P10, DOI 10.1016/j.tem.2007.10.004
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Fliser D, 2001, AM J KIDNEY DIS, V37, P79, DOI 10.1053/ajkd.2001.20591
   Flower DR, 1996, BIOCHEM J, V318, P1
   FOLSOM AR, 1993, ARTERIOSCLER THROMB, V13, P162, DOI 10.1161/01.ATV.13.2.162
   Fonseca V, 2003, METAB SYNDR RELAT D, V1, P95, DOI 10.1089/154041903322294416
   Ford ES, 2005, DIABETES CARE, V28, P1228, DOI 10.2337/diacare.28.5.1228
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Ford ES, 2003, ATHEROSCLEROSIS, V168, P351, DOI 10.1016/S0021-9150(03)00134-5
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   FRIDOVICH I, 1995, ANNU REV BIOCHEM, V64, P97, DOI 10.1146/annurev.bi.64.070195.000525
   Fried SK, 1998, J CLIN ENDOCR METAB, V83, P847, DOI 10.1210/jc.83.3.847
   Friedman JM, 1998, NATURE, V395, P763, DOI 10.1038/27376
   Fruchart JC, 2008, DIABETES VASC DIS RE, V5, P319, DOI 10.3132/dvdr.2008.046
   Fruebis J, 2001, P NATL ACAD SCI USA, V98, P2005, DOI 10.1073/pnas.041591798
   Fu YC, 2002, ATHEROSCLEROSIS, V165, P259, DOI 10.1016/S0021-9150(02)00305-2
   Fu YC, 2014, PROG MOL BIOL TRANSL, V121, P293, DOI 10.1016/B978-0-12-800101-1.00009-0
   Fujikawa R, 2015, DIABETOL INT, V6, P313, DOI 10.1007/s13340-015-0204-4
   Fulop T, 2006, PATHOL BIOL, V54, P375, DOI 10.1016/j.patbio.2006.07.002
   Furuhashi M, 2008, NAT REV DRUG DISCOV, V7, P489, DOI 10.1038/nrd2589
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Galletti F, 2007, J HYPERTENS, V25, P1671, DOI 10.1097/HJH.0b013e3281afa09e
   Gannage-Yared MH, 2006, EUR J ENDOCRINOL, V155, P167, DOI 10.1530/eje.1.02175
   Gannagé-Yared MH, 2006, CLIN ENDOCRINOL, V64, P652, DOI 10.1111/j.1365-2265.2006.02522.x
   Garcin J. -M., 2006, Metabolic Syndrome and Related Disorders, V4, P185, DOI 10.1089/met.2006.4.185
   Gattu AK, 2012, ACTA DIABETOL, V49, pS161, DOI 10.1007/s00592-012-0397-y
   Gavella M, 2003, ACTA DIABETOL, V40, P95
   Gayoso-Diz P, 2013, BMC ENDOCR DISORD, V13, DOI 10.1186/1472-6823-13-47
   Gelfand JM, 2012, J RHEUMATOL, V39, P24, DOI 10.3899/jrheum.120237
   Geloneze B, 2006, DIABETES RES CLIN PR, V72, P219, DOI 10.1016/j.diabres.2005.10.017
   Genc H, 2012, CLIN BIOCHEM, V45, P92, DOI 10.1016/j.clinbiochem.2011.10.022
   Genre F, 2013, CLIN EXP RHEUMATOL, V31, P532
   Genre F, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/860651
   George JA, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061282
   Gerkowicz A, 2012, FOLIA HISTOCHEM CYTO, V50, P155, DOI 10.5603/FHC.2012.0025
   Geroldi D, 2006, CURR MED CHEM, V13, P1971, DOI 10.2174/092986706777585013
   Gharibeh MY, 2010, DIABETES METAB, V36, P443, DOI 10.1016/j.diabet.2010.05.003
   Ghayour-Mobarhan M., 2008, Pakistan Journal of Nutrition, V7, P112
   Gilardini L, 2006, ATHEROSCLEROSIS, V189, P401, DOI 10.1016/j.atherosclerosis.2005.12.021
   Gimeno RE, 2014, TRENDS ENDOCRIN MET, V25, P303, DOI 10.1016/j.tem.2014.03.001
   Giral P, 2010, ATHEROSCLEROSIS, V210, P607, DOI 10.1016/j.atherosclerosis.2009.12.026
   Girillo P, 2006, J AM SOC NEPHROL, V17, pS165, DOI 10.1681/ASN.2006080909
   Gisondi P, 2007, BRIT J DERMATOL, V157, P68, DOI 10.1111/j.1365-2133.2007.07986.x
   Giustarini D, 2009, CRIT REV CL LAB SCI, V46, P241, DOI 10.3109/10408360903142326
   Gokulakrishnan K, 2006, METABOLISM, V55, P237, DOI 10.1016/j.metabol.2005.08.019
   Goldfine AB, 2003, LANCET, V362, P1431, DOI 10.1016/S0140-6736(03)14727-7
   Goldminz AM, 2013, PEDIATR DERMATOL, V30, P700, DOI 10.1111/pde.12218
   Golledge J, 2008, CARDIOLOGY, V111, P51, DOI 10.1159/000113428
   Gong HP, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-13
   González AS, 2006, EUR J CLIN NUTR, V60, P802, DOI 10.1038/sj.ejcn.1602384
   González M, 2012, EUR J CLIN NUTR, V66, P1141, DOI 10.1038/ejcn.2012.112
   Gooren L, 2008, J MENS HEALTH, V5, pS2, DOI 10.1016/j.jomh.2008.03.008
   Gosling J, 1999, J CLIN INVEST, V103, P773, DOI 10.1172/JCI5624
   Graham TE, 2006, NEW ENGL J MED, V354, P2552, DOI 10.1056/NEJMoa054862
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Grundy SM, 2007, ARTERIOSCL THROM VAS, V27, P4, DOI 10.1161/01.ATV.0000253905.13219.4b
   Guerre-Millo M, 2008, DIABETES METAB, V34, P12, DOI 10.1016/j.diabet.2007.08.002
   Gunawan S, 2011, INDONES BIOMED J, V3, P57, DOI 10.18585/inabj.v3i1.135
   Gupta V, 2011, Toxicol Int, V18, P168, DOI 10.4103/0971-6580.84272
   Gupta V, 2010, DIABETES METAB SYND, V4, P239, DOI 10.1016/j.dsx.2010.05.002
   Gustafson B, 2007, ARTERIOSCL THROM VAS, V27, P2276, DOI 10.1161/ATVBAHA.107.147835
   Guven A, 2005, HEART VESSELS, V20, P290, DOI 10.1007/s00380-004-0822-4
   Guven A, 2006, ANGIOLOGY, V57, P295, DOI 10.1177/000331970605700305
   Guzzetti C, 2014, J ENDOCRINOL INVEST, V37, P51, DOI 10.1007/s40618-013-0014-0
   Gvozdenko TA, 2013, INT J BIOMED, V3, P67
   Haffner SM, 2006, AM J MED, V119, p3S, DOI 10.1016/j.amjmed.2006.01.008
   Hajer GR, 2007, HEART, V93, P216, DOI 10.1136/hrt.2006.093971
   HALAAS JL, 1995, SCIENCE, V269, P543, DOI 10.1126/science.7624777
   Halberg N, 2008, ENDOCRIN METAB CLIN, V37, P753, DOI 10.1016/j.ecl.2008.07.002
   Haley KJ, 2000, CIRCULATION, V102, P2185
   Hamaguchi M, 2005, ANN INTERN MED, V143, P722, DOI 10.7326/0003-4819-143-10-200511150-00009
   Hammad I.K., 2013, IRAQI J COMMUNITY ME, V11, P37
   Hamnvik OPR, 2015, INT J OBESITY, V39, P260, DOI 10.1038/ijo.2014.106
   Hannemann A, 2011, EUR J ENDOCRINOL, V164, P751, DOI 10.1530/EJE-10-1074
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Hara S, 2012, METABOLISM, V61, P281, DOI 10.1016/j.metabol.2011.06.026
   Harrington JR, 2000, STEM CELLS, V18, P65, DOI 10.1634/stemcells.18-1-65
   Hathcock JN, 2005, AM J CLIN NUTR, V81, P736, DOI 10.1093/ajcn/81.4.736
   Hauner H, 2005, P NUTR SOC, V64, P163, DOI 10.1079/PNS2005428
   Hayden Melvin R, 2004, Nutr Metab (Lond), V1, P10, DOI 10.1186/1743-7075-1-10
   He MA, 2010, ARTERIOSCL THROM VAS, V30, P885, DOI 10.1161/ATVBAHA.109.199422
   Hedblad B, 2000, DIABETIC MED, V17, P299, DOI 10.1046/j.1464-5491.2000.00280.x
   Hegyi K, 2004, CELL BIOL INT, V28, P159, DOI 10.1016/j.cellbi.2003.12.003
   Heidemann C, 2008, ANN INTERN MED, V149, P307, DOI 10.7326/0003-4819-149-5-200809020-00005
   Heilbronn LK, 2004, J CLIN ENDOCR METAB, V89, P1844, DOI 10.1210/jc.2003-031410
   Heima NE, 2013, EUR J ENDOCRINOL, V168, P59, DOI 10.1530/EJE-12-0375
   Henry M, 1998, ARTERIOSCL THROM VAS, V18, P84, DOI 10.1161/01.ATV.18.1.84
   Herman MA, 2006, J CLIN INVEST, V116, P1767, DOI 10.1172/JCI29027
   Hermans N, 2007, CURR MED CHEM, V14, P417, DOI 10.2174/092986707779941005
   Hermans N, 2007, J PHARM PHARMACOL, V59, P131, DOI 10.1211/jpp.59.1.0017
   Heymsfield SB, 1999, JAMA-J AM MED ASSOC, V282, P1568, DOI 10.1001/jama.282.16.1568
   Hida K, 2005, P NATL ACAD SCI USA, V102, P10610, DOI 10.1073/pnas.0504703102
   Higdon JV, 2003, ARTERIOSCL THROM VAS, V23, P365, DOI 10.1161/01.ATV.0000063608.43095.E2
   Hill JO, 2001, NUTRITION, V17, P975, DOI 10.1016/S0899-9007(01)00680-3
   Hjelmesæth J, 2009, CARDIOVASC DIABETOL, V8, DOI 10.1186/1475-2840-8-7
   Ho RC, 2005, CYTOKINE, V30, P14, DOI 10.1016/j.cyto.2004.10.015
   Hofbauer LC, 2004, JAMA-J AM MED ASSOC, V292, P490, DOI 10.1001/jama.292.4.490
   Holick MF, 2007, NEW ENGL J MED, V357, P266, DOI 10.1056/NEJMra070553
   Holvoet P, 2006, ARTERIOSCL THROM VAS, V26, pE31, DOI 10.1161/01.ATV.0000210271.36395.43
   Holvoet P, 2004, DIABETES, V53, P1068, DOI 10.2337/diabetes.53.4.1068
   Holvoet P, 2008, JAMA-J AM MED ASSOC, V299, P2287, DOI 10.1001/jama.299.19.2287
   Holvoet P, 2008, FUTURE LIPIDOL, V3, P637, DOI 10.2217/17460875.3.6.637
   Hopps E, 2010, NUTR METAB CARDIOVAS, V20, P72, DOI 10.1016/j.numecd.2009.06.002
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Hotta K, 2000, ARTERIOSCL THROM VAS, V20, P1595, DOI 10.1161/01.ATV.20.6.1595
   Howard JM, 2010, OBES REV, V11, P863, DOI 10.1111/j.1467-789X.2010.00718.x
   Hsieh JC, 2013, ARCH MED RES, V44, P215, DOI 10.1016/j.arcmed.2013.03.001
   Hsu BG, 2012, TRANSPL P, V44, P646, DOI 10.1016/j.transproceed.2011.11.008
   Hsu BG, 2010, CIRC J, V74, P327, DOI 10.1253/circj.CJ-09-0568
   Hu E, 1996, J BIOL CHEM, V271, P10697, DOI 10.1074/jbc.271.18.10697
   Hu WJ, 2013, J CLIN ENDOCR METAB, V98, P290, DOI 10.1210/jc.2012-2466
   Huang F, 2013, PLOS ONE, V8
   Huang X, 2014, J INTERN MED, V275, P71, DOI 10.1111/joim.12130
   Huang XD, WORLD J GASTROENTERO, V4, P2888
   Huang Y, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-11
   Huffman FG, 2009, ETHNIC DIS, V19, P115
   Hulthe J, 2000, ARTERIOSCL THROM VAS, V20, P2140, DOI 10.1161/01.ATV.20.9.2140
   Hulthe J, 2003, METABOLISM, V52, P1612, DOI 10.1016/S0026-0495(03)00313-5
   Hutcheson R, 2012, EXP DIABETES RES, DOI 10.1155/2012/271028
   Hwang HJ, 2010, CLIN CHIM ACTA, V411, P1496, DOI 10.1016/j.cca.2010.06.003
   Ikai E, 1993, Obes Res, V1, P469
   IKAI E, 1994, J HUM HYPERTENS, V8, P95
   Imperatore G, 1998, DIABETES CARE, V21, P649, DOI 10.2337/diacare.21.4.649
   Ingelsson E, 2008, EUR J CLIN INVEST, V38, P502, DOI 10.1111/j.1365-2362.2008.01962.x
   Ingelsson E, 2007, CIRCULATION, V116, P984, DOI 10.1161/CIRCULATIONAHA.107.708537
   Inoue T, 2001, J AM COLL CARDIOL, V37, P775, DOI 10.1016/S0735-1097(00)01199-2
   ISHIKAWA T, 1978, EUR J CLIN INVEST, V8, P179, DOI 10.1111/j.1365-2362.1978.tb00832.x
   Isogawa A, 2009, DIABETES RES CLIN PR, V86, P213, DOI 10.1016/j.diabres.2009.09.007
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Itani SI, 2002, DIABETES, V51, P2005, DOI 10.2337/diabetes.51.7.2005
   Itoh N, 2004, TRENDS GENET, V20, P563, DOI 10.1016/j.tig.2004.08.007
   Iwen KA, 2013, EUR THYROID J, V2, P83, DOI 10.1159/000351249
   Ix JH, 2006, CIRCULATION, V113, P1760, DOI 10.1161/CIRCULATIONAHA.105.588723
   Jacobs M, 2009, EUR J CLIN INVEST, V39, P437, DOI 10.1111/j.1365-2362.2009.02129.x
   Jang Y, 2012, CLIN EXP PHARMACOL P, V39, P194, DOI 10.1111/j.1440-1681.2011.05557.x
   Jehn M, 2004, DIABETES CARE, V27, P2422, DOI 10.2337/diacare.27.10.2422
   Jeppesen J, 2007, J AM COLL CARDIOL, V49, P2112, DOI 10.1016/j.jacc.2007.01.088
   Jia WP, 2007, J CLIN ENDOCR METAB, V92, P3224, DOI 10.1210/jc.2007-0209
   Jialal I, 2005, J NUTR, V135, P348, DOI 10.1093/jn/135.2.348
   Jialal I, 2013, J CLIN ENDOCR METAB, V98, pE514, DOI 10.1210/jc.2012-3673
   Jialal I, 2012, J CLIN ENDOCR METAB, V97, pE1844, DOI 10.1210/jc.2012-2498
   JIANG XZ, 1993, ARCH INTERN MED, V153, P323, DOI 10.1001/archinte.153.3.323
   Jin H, 2010, J CLIN PSYCHIAT, V71, P1273, DOI 10.4088/JCP.09m05414yel
   Johnson BD, 2004, CIRCULATION, V109, P726, DOI 10.1161/01.CIR.0000115516.54550.B1
   Jones AG, 2013, DIABETIC MED, V30, P803, DOI 10.1111/dme.12159
   Jung Chan-Hee, 2010, Korean Diabetes J, V34, P237, DOI 10.4093/kdj.2010.34.4.237
   Jylhävä J, 2009, J INTERN MED, V266, P286, DOI 10.1111/j.1365-2796.2009.02120.x
   Kadowaki T, 2006, J CLIN INVEST, V116, P1784, DOI 10.1172/JCI29126
   Kamei N, 2006, J BIOL CHEM, V281, P26602, DOI 10.1074/jbc.M601284200
   Kanbak G, 2011, DIABETES METAB SYND, V5, P7, DOI 10.1016/j.dsx.2010.05.006
   Kanda H, 2006, J CLIN INVEST, V116, P1494, DOI 10.1172/JCI26498
   Kang ES, 2005, DIABETES RES CLIN PR, V69, P151, DOI 10.1016/j.diabres.2004.11.014
   Kang JY, 2012, J KOREAN MED SCI, V27, P500, DOI 10.3346/jkms.2012.27.5.500
   Kappelle PJWH, 2011, ARCH MED RES, V42, P219, DOI 10.1016/j.arcmed.2011.05.002
   Karakas SE, 2009, METABOLISM, V58, P1002, DOI 10.1016/j.metabol.2009.02.024
   Karasawa K, 2003, PROG LIPID RES, V42, P93, DOI 10.1016/S0163-7827(02)00049-8
   Karatela Rubina A, 2009, Indian Heart J, V61, P156
   Karbek B, 2014, MINERVA ENDOCRINOL, V39, P99
   Katugampola SD, 2002, CAN J PHYSIOL PHARM, V80, P369, DOI 10.1139/Y02-029
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kaur S, 2009, METAB SYNDR RELAT D, V7, P193, DOI 10.1089/met.2008.0064
   Kayaniyil S, 2011, J CLIN ENDOCR METAB, V96, P168, DOI 10.1210/jc.2010-1439
   Kazumi T, 2006, HORM METAB RES, V38, P119, DOI 10.1055/s-2006-925134
   Kelishadi R, 2008, CLIN ENDOCRINOL, V69, P721, DOI 10.1111/j.1365-2265.2008.03220.x
   Kelishadi R, 2013, PAK J MED SCI, V29, P290, DOI 10.12669/pjms.291(Suppl).3519
   Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2548, DOI 10.1210/jc.2004-0395
   Keskin M, 2005, PEDIATRICS, V115, pE500, DOI 10.1542/peds.2004-1921
   Kharitonenkov A, 2005, J CLIN INVEST, V115, P1627, DOI 10.1172/JCI23606
   Kidambi S, 2007, HYPERTENSION, V49, P704, DOI 10.1161/01.HYP.0000253258.36141.c7
   Kidoya H, 2012, J BIOCHEM, V152, P125, DOI 10.1093/jb/mvs071
   Kilic DC, 2011, J ENDOCRINOL METAB, V1, P182, DOI 10.4021/jem46w
   Kim CH, 2011, METABOLISM, V60, P414, DOI 10.1016/j.metabol.2010.03.007
   Kim JY, 2013, DIABETES CARE, V36, P1547, DOI 10.2337/dc12-0223
   Kim KM, 2012, ARCH MED RES, V43, P288, DOI 10.1016/j.arcmed.2012.05.003
   Kim SH, 2011, SCAND J CLIN LAB INV, V71, P1, DOI 10.3109/00365513.2010.519047
   Kim SH, 2014, CLIN ENDOCRINOL, V80, P825, DOI 10.1111/cen.12249
   Kitaura M, 1996, J BIOL CHEM, V271, P7725, DOI 10.1074/jbc.271.13.7725
   Kitsios K, 2013, J CLIN RES PEDIATR E, V5, P44, DOI 10.4274/Jcrpe.789
   KJELDSEN L, 1993, J BIOL CHEM, V268, P10425
   Klöting N, 2006, BIOCHEM BIOPH RES CO, V339, P430, DOI 10.1016/j.bbrc.2005.11.039
   KLUVEBECKERMAN B, 1991, DNA CELL BIOL, V10, P651, DOI 10.1089/dna.1991.10.651
   Knopp RH, 2006, AM J CLIN NUTR, V83, P1
   Knudsen N, 2005, J CLIN ENDOCR METAB, V90, P4019, DOI 10.1210/jc.2004-2225
   Ko BJ, 2014, INT J OBESITY, V38, P1497, DOI 10.1038/ijo.2014.45
   Koc F., 2011, European Journal of General Medicine, V8, P92
   Koda M, 2010, BMC CANCER, V10, DOI 10.1186/1471-2407-10-320
   Koerner A, 2005, BEST PRACT RES CL EN, V19, P525, DOI 10.1016/j.beem.2005.07.008
   Koh JH, 2009, DIABETES CARE, V32, P147, DOI 10.2337/dc08-1379
   Koh KK, 2005, J AM COLL CARDIOL, V46, P1978, DOI 10.1016/j.jacc.2005.06.082
   Koh SB, 2011, YONSEI MED J, V52, P234, DOI 10.3349/ymj.2011.52.2.234
   Kojima M, 2001, TRENDS ENDOCRIN MET, V12, P118, DOI 10.1016/S1043-2760(00)00362-3
   Konopleva M, 1999, BLOOD, V93, P1668, DOI 10.1182/blood.V93.5.1668.405a15_1668_1676
   Konturek SJ, 2005, J PHYSIOL PHARMACOL, V56, P507
   Kosola J, 2013, METABOLISM, V62, P992, DOI 10.1016/j.metabol.2013.01.013
   Kotani K, 2008, GERONTOLOGY, V54, P361, DOI 10.1159/000145541
   Kotani K, 2011, J CLIN LIPIDOL, V5, P395, DOI 10.1016/j.jacl.2011.08.001
   Kotani K, 2009, ATHEROSCLEROSIS, V204, P526, DOI 10.1016/j.atherosclerosis.2008.09.017
   Kotnik P, 2011, EUR J ENDOCRINOL, V165, P703, DOI 10.1530/EJE-11-0431
   Kowalska I, 2008, END ABSTR, V16, pP531
   Kowdley KV, 2012, HEPATOLOGY, V55, P77, DOI 10.1002/hep.24706
   Kralisch S, 2013, DIABETOLOGIA, V56, P10, DOI 10.1007/s00125-012-2737-4
   Kralisch S, 2013, J ENDOCRINOL, V216, P135, DOI 10.1530/JOE-12-0367
   Krug AW, 2008, HYPERTENSION, V51, P1252, DOI 10.1161/HYPERTENSIONAHA.107.109439
   Kumar HK, 2009, SAUDI MED J, V30, P907
   Kusminski CM, 2009, CLIN PHARMACOL THER, V86, P592, DOI 10.1038/clpt.2009.155
   Kusminski CM, 2005, CLIN SCI, V109, P243, DOI 10.1042/CS20050078
   KWITEROVICH PO, 1992, AM J CARDIOL, V69, P1015, DOI 10.1016/0002-9149(92)90856-T
   Kwon KM, 2011, J WOMENS HEALTH, V20, P963, DOI 10.1089/jwh.2010.2453
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lamarche B, 1996, CIRCULATION, V94, P273, DOI 10.1161/01.CIR.94.3.273
   Lammert A, 2001, BIOCHEM BIOPH RES CO, V283, P982, DOI 10.1006/bbrc.2001.4885
   Lanaspa MA, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0047948, 10.1371/journal.pone.0048801]
   Langan SM, 2012, J INVEST DERMATOL, V132, P556, DOI 10.1038/jid.2011.365
   Langenberg C, 2005, J CLIN ENDOCR METAB, V90, P6448, DOI 10.1210/jc.2005-1358
   Lann D, 2007, MED CLIN N AM, V91, P1063, DOI 10.1016/j.mcna.2007.06.012
   Lapointe A, 2007, ATHEROSCLEROSIS, V191, P362, DOI 10.1016/j.atherosclerosis.2006.03.036
   Lau CH, 2013, BIOCHEM GENET, V51, P166, DOI 10.1007/s10528-012-9552-y
   Lau CH, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-8
   Lau DCW, 2005, AM J PHYSIOL-HEART C, V288, pH2031, DOI 10.1152/ajpheart.01058.2004
   Lawlor DA, 2005, AM J EPIDEMIOL, V161, P1081, DOI 10.1093/aje/kwi125
   Lazar MA, 2007, HORM METAB RES, V39, P710, DOI 10.1055/s-2007-985897
   Lee BK, 2011, METABOLISM, V60, P1416, DOI 10.1016/j.metabol.2011.02.008
   Lee CJ, 2008, PERITON DIALYSIS INT, V28, pS196
   Lee DM, 2009, EUR J ENDOCRINOL, V161, P947, DOI 10.1530/EJE-09-0496
   Lee DH, 2005, CLIN CHEM, V51, P1185, DOI 10.1373/clinchem.2004.045872
   Lee DH, 2004, J HUM HYPERTENS, V18, P803, DOI 10.1038/sj.jhh.1001742
   Lee DH, 2003, CLIN CHEM, V49, P1358, DOI 10.1373/49.8.1358
   Lee DS, 2007, ARTERIOSCL THROM VAS, V27, P127, DOI 10.1161/01.ATV.0000251993.20372.40
   Lee JG, 2009, CLIN CHIM ACTA, V408, P50, DOI 10.1016/j.cca.2009.07.006
   Lee JH, 2003, J CLIN ENDOCR METAB, V88, P4848, DOI 10.1210/jc.2003-030519
   Lee JW, 2007, OBESITY, V15, P2225, DOI 10.1038/oby.2007.264
   Lee Ju-Mi, 2012, J Prev Med Public Health, V45, P181, DOI 10.3961/jpmph.2012.45.3.181
   Lee MJ, 2014, DIABETES METAB, V40, P305, DOI 10.1016/j.diabet.2014.04.006
   Lee M, 2011, ATHEROSCLEROSIS, V217, P492, DOI 10.1016/j.atherosclerosis.2011.04.020
   Lee S, 2006, J KOREAN MED SCI, V21, P695
   Lee WL, 2006, METABOLISM, V55, P1029, DOI 10.1016/j.metabol.2006.03.013
   Lee YS, 2008, MOL ENDOCRINOL, V22, P2176, DOI 10.1210/me.2008-0023
   Lehrke M, 2009, EUR J ENDOCRINOL, V161, P339, DOI 10.1530/EJE-09-0380
   Leiva E, 2010, EXP THER MED, V1, P175, DOI 10.3892/etm_00000028
   Leiva E, 2013, BIOL TRACE ELEM RES, V151, P1, DOI 10.1007/s12011-012-9525-3
   LEVIN EG, 1987, BLOOD, V70, P1090
   Li HQ, 2011, J HUAZHONG U SCI-MED, V31, P312, DOI 10.1007/s11596-011-0373-8
   Li J, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0074168
   Li TC, 2004, J GASTROENTEROL, V39, P1170, DOI 10.1007/s00535-004-1467-x
   Li WC, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-36
   Li WY, 2011, INTERNAL MED, V50, P1143, DOI 10.2169/internalmedicine.50.4765
   Li Y, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0113915
   Li ZP, 2013, METAB SYNDR RELAT D, V11, P87, DOI 10.1089/met.2012.0090
   Libby P, 2006, J AM COLL CARDIOL, V48, pA33, DOI 10.1016/j.jacc.2006.08.011
   Lin LY, 2009, ATHEROSCLEROSIS, V203, P563, DOI 10.1016/j.atherosclerosis.2008.07.021
   Ordovas JM, 2008, KIDNEY INT, V74, pS10, DOI 10.1038/ki.2008.517
   Feoli AMP, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/587083
   de Ciriza CP, 2014, CLIN BIOCHEM, V47, P272, DOI 10.1016/j.clinbiochem.2014.09.004
   Bernal-Lopez MR, 2013, DIABETES CARE, V36, P1006, DOI 10.2337/dc12-1030
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Gottlieb MGV, 2010, J CLIN ENDOCR METAB, V95, P586, DOI 10.1210/jc.2009-1592
   Zulet MA, 2009, NUTR RES, V29, P41, DOI 10.1016/j.nutres.2008.11.003
   Lin JD, 2007, METABOLISM, V56, P751, DOI 10.1016/j.metabol.2007.01.006
   Lin Y, 2001, J BIOL CHEM, V276, P42077, DOI 10.1074/jbc.M107101200
   LINDBERG G, 1991, BRIT MED J, V302, P143, DOI 10.1136/bmj.302.6769.143
   LINDBERG G, 1992, INT J EPIDEMIOL, V21, P253, DOI 10.1093/ije/21.2.253
   Lindsay RS, 2002, LANCET, V360, P57, DOI 10.1016/S0140-6736(02)09335-2
   Liu A, 2013, NUTR METAB CARDIOVAS, V23, P1122, DOI 10.1016/j.numecd.2012.12.001
   Liu MY, 2005, CLIN CHEM, V51, P1102, DOI 10.1373/clinchem.2004.047084
   Liu PJ, 2015, MENOPAUSE, V22, P217, DOI [10.1097/gme.0000000000000306, 10.1097/GME.0000000000000306]
   Liu P, 2014, REV PORT CARDIOL, V33, P411, DOI 10.1016/j.repc.2014.01.019
   Liu S, 2012, END ABSTR, V29, pP284
   Liu XW, 2011, EUR J ENDOCRINOL, V165, P805, DOI 10.1530/EJE-11-0660
   Liu Y, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-25
   Locatelli F, 2006, J AM SOC NEPHROL, V17, pS81, DOI 10.1681/ASN.2005121332
   Loguercio C, 2004, DIGEST LIVER DIS, V36, P398, DOI 10.1016/j.dld.2004.01.022
   Lorenz MW, 2007, CIRCULATION, V115, P459, DOI 10.1161/CIRCULATIONAHA.106.628875
   Loughrey BV, 2013, CLIN ENDOCRINOL, V79, P800, DOI 10.1111/cen.12113
   Lu JY, 2008, J BIOMED SCI, V15, P565, DOI 10.1007/s11373-008-9261-z
   Lüdtke A, 2005, AM J GASTROENTEROL, V100, P2218, DOI 10.1111/j.1572-0241.2005.00234.x
   Luptáková L, 2013, ANN HUM BIOL, V40, P132, DOI 10.3109/03014460.2012.748828
   MACDOUGALD OA, 1995, P NATL ACAD SCI USA, V92, P9034, DOI 10.1073/pnas.92.20.9034
   Madanagobalane Shraddha, 2012, Indian J Dermatol, V57, P353, DOI 10.4103/0019-5154.100474
   Maeda K, 2005, CELL METAB, V1, P107, DOI 10.1016/j.cmet.2004.12.008
   Maeda K, 1996, BIOCHEM BIOPH RES CO, V221, P286, DOI 10.1006/bbrc.1996.0587
   MAFFEI M, 1995, NAT MED, V1, P1155, DOI 10.1038/nm1195-1155
   Magnusson M, 2013, J INTERN MED, V274, P192, DOI 10.1111/joim.12051
   Makowski L, 2005, CURR OPIN LIPIDOL, V16, P543, DOI 10.1097/01.mol.0000180166.08196.07
   Malik S, 2005, DIABETES CARE, V28, P690, DOI 10.2337/diacare.28.3.690
   Mallbris L, 2002, EXP DERMATOL, V11, P584, DOI 10.1034/j.1600-0625.2002.110611.x
   Mallbris Lotus, 2006, Curr Rheumatol Rep, V8, P355, DOI 10.1007/s11926-006-0065-8
   Malo E, 2011, METAB SYNDR RELAT D, V9, P203, DOI 10.1089/met.2010.0106
   Mangoni AA, 2002, AM J MED, V112, P556, DOI 10.1016/S0002-9343(02)01021-5
   Mankowska-Cyl A, 2013, BIOMARK MED, V7, P723, DOI 10.2217/bmm.13.61
   Mansoub S, 2006, CLIN BIOCHEM, V39, P569, DOI 10.1016/j.clinbiochem.2006.02.013
   Marchesini G, 2001, DIABETES, V50, P1844, DOI 10.2337/diabetes.50.8.1844
   Margetic S, 2002, INT J OBESITY, V26, P1407, DOI 10.1038/sj.ijo.0802142
   Moreno-Navarrete JM, 2011, OBESITY, V19, P1552, DOI 10.1038/oby.2010.351
   Yubero-Serrano EM, 2013, EXP MOL MED, V45, DOI 10.1038/emm.2013.53
   Martinelli N, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048250
   Martinez-Razo G., 2013, Food and Nutrition Sciences, V4, P51
   Martini LA, 2006, NUTR REV, V64, P479, DOI 10.1111/j.1753-4887.2006.tb00180.x
   Matarese G, 2005, J IMMUNOL, V174, P3137, DOI 10.4049/jimmunol.174.6.3137
   Mateo-Gallego R, 2010, METABOLISM, V59, P154, DOI 10.1016/j.metabol.2009.06.021
   Matfin G, 2007, BR J DIABETES VASC D, V7, P101
   Mather KJ, 2002, DIABETES, V51, P3517, DOI 10.2337/diabetes.51.12.3517
   Matsubara M, 2002, J CLIN ENDOCR METAB, V87, P2764, DOI 10.1210/jc.87.6.2764
   Matsushita K, 2006, ARTERIOSCL THROM VAS, V26, P871, DOI 10.1161/01.ATV.0000208363.85388.8f
   Matsuura F, 1998, METABOLISM, V47, P929, DOI 10.1016/S0026-0495(98)90346-8
   MATSUZAWA Y, 1995, OBES RES, V3, pS187, DOI 10.1002/j.1550-8528.1995.tb00462.x
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mavrakanas T, 2009, PRESSE MED, V38, P1399, DOI 10.1016/j.lpm.2009.02.023
   Maxwell SRJ, 1997, EUR J CLIN INVEST, V27, P484, DOI 10.1046/j.1365-2362.1997.1390687.x
   Mazzone GL, 2009, BIOCHEM BIOPH RES CO, V386, P338, DOI 10.1016/j.bbrc.2009.06.029
   McDermott DH, 2005, CIRCULATION, V112, P1113, DOI 10.1161/CIRCULATIONAHA.105.543579
   McLaughlin T, 2004, J CLIN ENDOCR METAB, V89, P1630, DOI 10.1210/jc.2003-031572
   MCLEAN JW, 1987, NATURE, V330, P132, DOI 10.1038/330132a0
   McTernan PG, 2006, CURR OPIN LIPIDOL, V17, P170, DOI 10.1097/01.mol.0000217899.59820.9a
   Mebazaa A, 2011, J EUR ACAD DERMATOL, V25, P705, DOI 10.1111/j.1468-3083.2010.03856.x
   Medzhitov R, 2008, NATURE, V454, P428, DOI 10.1038/nature07201
   Meister A, 1979, Ciba Found Symp, P135
   Mertens I, 2006, INT J OBESITY, V30, P1308, DOI 10.1038/sj.ijo.0803189
   Mi J, 2010, J OBES, V2010, DOI 10.1155/2010/892081
   Miller MA, 2006, INT J OBESITY, V30, P1176, DOI 10.1038/sj.ijo.0803264
   Milner KL, 2009, HEPATOLOGY, V49, P1926, DOI 10.1002/hep.22896
   Misra M, 2008, AM J PHYSIOL-ENDOC M, V295, pE385, DOI 10.1152/ajpendo.00052.2008
   Mittal M, 2014, ANTIOXID REDOX SIGN, V20, P1126, DOI 10.1089/ars.2012.5149
   Moaty MIA, 2012, MACED J MED SCI, V5, P147
   Mohamed-Ali V, 1997, J CLIN ENDOCR METAB, V82, P4196, DOI 10.1210/jc.82.12.4196
   Mohan V, 2005, METABOLISM, V54, P476, DOI 10.1016/j.metabol.2004.10.016
   Mokhort T., 2007, END ABSTR, V14, pP230
   Monteiro R, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/289645
   Montgomery JE, 2013, VASC HEALTH RISK MAN, V9, P37, DOI 10.2147/VHRM.S30378
   Moon YS, 2004, METABOLISM, V53, P863, DOI 10.1016/j.metabol.2004.02.007
   Morgenthaler NG, 2006, CLIN CHEM, V52, P112, DOI 10.1373/clinchem.2005.060038
   Muccioli G, 2002, EUR J PHARMACOL, V440, P235, DOI 10.1016/S0014-2999(02)01432-2
   Muntner P, 2004, ANN EPIDEMIOL, V14, P686, DOI 10.1016/j.annepidem.2004.01.002
   Muraleedharan V, 2010, THER ADV ENDOCRINOL, V1, P207, DOI 10.1177/2042018810390258
   Musani SK, 2013, DIABETES CARE, V36, P3084, DOI 10.2337/dc12-2562
   Mussi A, 1997, J BIOL REG HOMEOS AG, V11, P115
   Mutakin, 2013, J TRACE ELEM MED BIO, V27, P112, DOI 10.1016/j.jtemb.2012.09.006
   Myers MG, 2008, ANNU REV PHYSIOL, V70, P537, DOI 10.1146/annurev.physiol.70.113006.100707
   Nabipour I, 2009, J ENDOCRINOL INVEST, V32, P406, DOI 10.1007/BF03346476
   Nabipour I, 2010, METABOLISM, V59, P742, DOI 10.1016/j.metabol.2009.09.019
   Nakagawa H, 2012, J GASTROENTEROL, V47, P187, DOI 10.1007/s00535-011-0477-8
   Nakagawa T, 2006, AM J PHYSIOL-RENAL, V290, pF625, DOI 10.1152/ajprenal.00140.2005
   Nakai Y, 2002, DIABETIC MED, V19, P346, DOI 10.1046/j.1464-5491.2002.00712_3.x
   Nakamura K, 2009, DIABETES-METAB RES, V25, P52, DOI 10.1002/dmrr.820
   Nakanishi N, 2004, DIABETES CARE, V27, P1427, DOI 10.2337/diacare.27.6.1427
   Nakanishi N, 2000, OCCUP MED-OXFORD, V50, P115, DOI 10.1093/occmed/50.2.115
   Nakano Y, 1996, J BIOCHEM-TOKYO, V120, P803
   Nakao K, 2002, AM J GASTROENTEROL, V97, P1796, DOI 10.1111/j.1572-0241.2002.05846.x
   Natal C, 2008, J CLIN ENDOCR METAB, V93, P2319, DOI 10.1210/jc.2007-2491
   Navarro-Alarcón M, 2000, SCI TOTAL ENVIRON, V249, P347, DOI 10.1016/S0048-9697(99)00526-4
   Naveed B, 2012, AM J RESP CRIT CARE, V185, P392, DOI 10.1164/rccm.201109-1672OC
   Nayak B Shivananda, 2006, J Inflamm (Lond), V3, P17, DOI 10.1186/1476-9255-3-17
   Nayak Shivananda B, 2005, Lipids Health Dis, V4, P15, DOI 10.1186/1476-511X-4-15
   Ng TWK, 2007, DIABETES CARE, V30, P2945, DOI 10.2337/dc07-0768
   Ni J, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-176
   NILSSEN O, 1990, AM J EPIDEMIOL, V132, P318, DOI 10.1093/oxfordjournals.aje.a115661
   Ninomiya JK, 2004, CIRCULATION, V109, P42, DOI 10.1161/01.CIR.0000108926.04022.0C
   Nishimura T, 2000, BBA-GENE STRUCT EXPR, V1492, P203, DOI 10.1016/S0167-4781(00)00067-1
   Nobill V, 2012, BIOMARK MED, V6, P707, DOI [10.2217/BMM.12.93, 10.2217/bmm.12.93]
   Nofer JR, 2013, CLIN LIPIDOL, V8, P299, DOI 10.2217/CLP.13.27
   Norata GD, 2007, J INTERN MED, V262, P104, DOI 10.1111/j.1365-2796.2007.01787.x
   Norata GD, 2007, EUR J ENDOCRINOL, V156, P279, DOI 10.1530/eje.1.02338
   Norman AW., 2015, Hormones, VThird, P223
   Nourooz-Zadeh J, 1998, BIOCHEM BIOPH RES CO, V242, P338, DOI 10.1006/bbrc.1997.7883
   Novotny D, 2014, PHYSIOL RES, V63, P219, DOI 10.33549/physiolres.932602
   O'Leary DH, 1999, NEW ENGL J MED, V340, P14, DOI 10.1056/NEJM199901073400103
   Oda E, 2013, ACTA DIABETOL, V50, P417, DOI 10.1007/s00592-012-0447-5
   Ogawa Y, 2005, HYPERTENS RES, V28, P51, DOI 10.1291/hypres.28.51
   Olsen MH, 2005, HYPERTENSION, V46, P660, DOI 10.1161/01.HYP.0000179575.13739.72
   Olszanecka-Glinianowicz M, 2012, ARCH MED SCI, V8, P214, DOI 10.5114/aoms.2012.28547
   Olszanecka-Glinianowicz M, 2011, KARDIOL POL, V69, P802
   Onat A, 2006, AM J HYPERTENS, V19, P1055, DOI 10.1016/j.amjhyper.2006.02.014
   Onat A, 2006, PREV MED, V43, P136, DOI 10.1016/j.ypmed.2006.04.005
   Oral EA, 2002, NEW ENGL J MED, V346, P570, DOI 10.1056/NEJMoa012437
   Osawa H, 2008, CLIN ENDOCRINOL, V69, P74, DOI 10.1111/j.1365-2265.2007.03154.x
   Ouchi N, 2003, CIRCULATION, V107, P671, DOI 10.1161/01.CIR.0000055188.83694.B3
   Ouchi N, 1999, CIRCULATION, V100, P2473, DOI 10.1161/01.CIR.100.25.2473
   Ouchi N, 2010, SCIENCE, V329, P454, DOI 10.1126/science.1188280
   Ovist R., 2007, J MED SCI, V7, P1049
   Özbek M, 2011, TURK J ENDOCRINOL ME, V15, P57
   Pacifico L, 2009, EUR J ENDOCRINOL, V160, P45, DOI 10.1530/EJE-08-0618
   Palmieri VO, 2006, J NUTR, V136, P3022, DOI 10.1093/jn/136.12.3022
   Palmieri VO, 2013, EUR J CLIN INVEST, V43, P41, DOI 10.1111/eci.12013
   Palomo IG, 2009, MOL MED REP, V2, P253, DOI 10.3892/mmr_00000092
   Pan HY, 2010, DIABETES RES CLIN PR, V88, P29, DOI 10.1016/j.diabres.2010.01.013
   Paoletti R, 2006, VASC HEALTH RISK MAN, V2, P145, DOI 10.2147/vhrm.2006.2.2.145
   Papatheodorou K, 2013, ANGIOLOGY, V64, P223, DOI 10.1177/0003319712440143
   Papazafiropoulou A, 2011, J ENDOCRINOL METAB, V1, P92, DOI 10.4021/jem13w
   Park HT, 2009, MATURITAS, V62, P301, DOI 10.1016/j.maturitas.2009.01.007
   Park SH, 2012, J KOREAN MED SCI, V27, P1057, DOI 10.3346/jkms.2012.27.9.1057
   Park SK, 2012, DIABETES CARE, V35, P2521, DOI 10.2337/dc12-0543
   Pasquali R, 2006, ANN NY ACAD SCI, V1083, P111, DOI 10.1196/annals.1367.009
   Pasterkamp G, 2012, ARTERIOSCL THROM VAS, V32, P2043, DOI 10.1161/ATVBAHA.112.254797
   Patel L, 2003, BIOCHEM BIOPH RES CO, V300, P472, DOI 10.1016/S0006-291X(02)02841-3
   Patel SD, 2004, SCIENCE, V304, P1154, DOI 10.1126/science.1093466
   PELLEYMOUNTER MA, 1995, SCIENCE, V269, P540, DOI 10.1126/science.7624776
   Pepys MB, 2003, J CLIN INVEST, V111, P1805, DOI 10.1172/JCI200318921
   Pereira GB, 2013, CLIN PHYSIOL FUNCT I, V33, P122, DOI 10.1111/cpf.12004
   Perez-Pozo SE, 2010, INT J OBESITY, V34, P454, DOI 10.1038/ijo.2009.259
   Persson M, 2007, ARTERIOSCL THROM VAS, V27, P1411, DOI 10.1161/ATVBAHA.107.142679
   Persson M, 2007, ATHEROSCLEROSIS, V190, P388, DOI 10.1016/j.atherosclerosis.2006.02.016
   Petersen KF, 2002, J CLIN INVEST, V109, P1345, DOI 10.1172/JCI0215001
   Piatti PM, 2000, METABOLISM, V49, P748, DOI 10.1053/meta.2000.6257
   Picchi A, 2006, CIRC RES, V99, P69, DOI 10.1161/01.RES.0000229685.37402.80
   Pickup JC, 1997, DIABETOLOGIA, V40, P1286, DOI 10.1007/s001250050822
   Pickup JC, 1998, DIABETOLOGIA, V41, P1241, DOI 10.1007/s001250051058
   PinhasHamiel O, 1996, J PEDIATR-US, V128, P608, DOI 10.1016/S0022-3476(96)80124-7
   Pizent A, 2010, J NUTR HEALTH AGING, V14, P866, DOI 10.1007/s12603-010-0139-1
   Pohjantähti-Maaroos H, 2010, CARDIOVASC DIABETOL, V9, DOI 10.1186/1475-2840-9-41
   Potter JJ, 1998, BIOCHEM BIOPH RES CO, V244, P178, DOI 10.1006/bbrc.1997.8193
   Poulos SP, 2010, MOL CELL ENDOCRINOL, V323, P20, DOI 10.1016/j.mce.2009.12.011
   Powers CJ, 2000, ENDOCR-RELAT CANCER, V7, P165, DOI 10.1677/erc.0.0070165
   Pradhan AD, 2014, CLIN CHEM, V60, P44, DOI 10.1373/clinchem.2013.202549
   Presta I, 2009, Nutr Metab Cardiovasc Dis, V19, pe5, DOI 10.1016/j.numecd.2008.10.002
   Puchau B, 2009, EUR J CLIN NUTR, V63, P858, DOI 10.1038/ejcn.2008.48
   Pulkkinen Leena, 2010, Int J Pept, V2010, DOI 10.1155/2010/248948
   Pyorala K, 1979, Diabetes Care, V2, P131, DOI 10.2337/diacare.2.2.131
   Qasim AN, 2009, CLIN ENDOCRINOL, V70, P698, DOI 10.1111/j.1365-2265.2008.03375.x
   Qi QB, 2007, J CLIN ENDOCR METAB, V92, P4827, DOI 10.1210/jc.2007-1219
   Qi QB, 2012, EUR HEART J, V33, P325, DOI 10.1093/eurheartj/ehr350
   Qiu WB, 2014, DIABETES VASC DIS RE, V11, P121, DOI 10.1177/1479164113513912
   Qu HQ, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0021041
   Rantala AO, 2000, J INTERN MED, V248, P230, DOI 10.1046/j.1365-2796.2000.00723.x
   Rao PM, 2013, NAT REV ENDOCRINOL, V9, P479, DOI 10.1038/nrendo.2013.122
   Rasic Z, 2006, END ABSTR, V11, pP224
   Rasic-Milutinovic Z, 2007, INTERNAL MED, V46, P945, DOI 10.2169/internalmedicine.46.0092
   Rayman MP, 2000, LANCET, V356, P233, DOI 10.1016/S0140-6736(00)02490-9
   REAVEN GM, 1993, ANNU REV MED, V44, P121, DOI 10.1146/annurev.med.44.1.121
   REAVEN GM, 1994, J INTERN MED, V236, P13
   REAVEN GM, 1988, DIABETES, V37, P1020, DOI 10.2337/diabetes.37.8.1020
   Reganon E, 2007, THROMB RES, V119, P73, DOI 10.1016/j.thromres.2005.12.017
   Reid P, 2009, EUR J CELL BIOL, V88, P1, DOI 10.1016/j.ejcb.2008.06.004
   Reif A, 2005, PROG NEURO-PSYCHOPH, V29, P1162, DOI 10.1016/j.pnpbp.2005.06.027
   Rein P, 2010, DIABETES CARE, V33, P1853, DOI 10.2337/dc09-2376
   Reinehr T, 2004, HORM RES, V62, P107, DOI 10.1159/000079841
   Reinehr T, 2012, J CLIN ENDOCR METAB, V97, P2143, DOI 10.1210/jc.2012-1221
   Reis JP, 2007, DIABETES CARE, V30, P1549, DOI 10.2337/dc06-2438
   Relimpio F, 2002, DIABETES RES CLIN PR, V57, P199, DOI 10.1016/S0168-8227(02)00096-7
   RENDELL M, 1983, ACTA DIABETOL LAT, V20, P105, DOI 10.1007/BF02624911
   Rentsch J, 1996, FEBS LETT, V379, P55, DOI 10.1016/0014-5793(95)01485-3
   Retnakaran R, 2007, PEDIATR NEPHROL, V22, P1007, DOI 10.1007/s00467-007-0471-9
   Rhee EJ, 2009, EUR J ENDOCRINOL, V160, P165, DOI 10.1530/EJE-08-0665
   Riccardi G, 2004, CLIN NUTR, V23, P447, DOI 10.1016/j.clnu.2004.02.006
   Richard C, 2014, ARTERIOSCL THROM VAS, V34, P433, DOI 10.1161/ATVBAHA.113.302185
   Ridker PM, 2008, NEW ENGL J MED, V359, P2195, DOI 10.1056/NEJMoa0807646
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   Ridker PM, 2004, CIRCULATION, V109, P2818, DOI 10.1161/01.CIR.0000132467.45278.59
   Ridker PM, 2001, CIRCULATION, V103, P1813, DOI 10.1161/01.CIR.103.13.1813
   Ridker PM, 2000, NEW ENGL J MED, V342, P836, DOI 10.1056/NEJM200003233421202
   Rizos E, 2005, PROSTAG LEUKOTR ESS, V72, P203, DOI 10.1016/j.plefa.2004.10.021
   Robberecht H, NUTR RES REV UNPUB
   Robberecht H, 2012, TRACE ELEM ELECTROLY, V29, P172, DOI 10.5414/TE0X1237
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   ROBINSON D, 1989, ANN CLIN BIOCHEM, V26, P393, DOI 10.1177/000456328902600503
   Rochlitz H, 2005, DEUT MED WOCHENSCHR, V130, P1061, DOI 10.1055/s-2005-866789
   Rodrigues SL, 2012, ARQ BRAS CARDIOL, V98, P13, DOI 10.1590/S0066-782X2011005000116
   RohnerJeanrenaud F, 1996, HORM METAB RES, V28, P642, DOI 10.1055/s-2007-979870
   Roislien J, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-17
   Romaní J, 2013, ARCH DERMATOL RES, V305, P105, DOI 10.1007/s00403-012-1306-5
   Rongvaux A, 2002, EUR J IMMUNOL, V32, P3225, DOI 10.1002/1521-4141(200211)32:11<3225::AID-IMMU3225>3.0.CO;2-L
   Rosenson RS, 2009, OBESITY, V17, P504, DOI 10.1038/oby.2008.530
   Rosety-Rodriguez M, 2012, INT J EXERC SCI C P, V1
   Rosmond R, 1998, J CLIN ENDOCR METAB, V83, P1853, DOI 10.1210/jc.83.6.1853
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Rubin D, 2008, LIPIDS HEALTH DIS, V7, DOI 10.1186/1476-511X-7-32
   Rueda S, 2008, OBES SURG, V18, P151, DOI 10.1007/s11695-007-9352-3
   Ruhla S, 2010, CLIN ENDOCRINOL, V72, P696, DOI 10.1111/j.1365-2265.2009.03698.x
   Ruotolo Giacomo, 2002, Curr Cardiol Rep, V4, P494, DOI 10.1007/s11886-002-0113-6
   Rutter MK, 2004, CIRCULATION, V110, P380, DOI 10.1161/01.CIR.0000136581.59584.0E
   Rychli K, 2009, EXPERT OPIN THER TAR, V13, P1295, DOI 10.1517/14728220903241641
   Ryo M, 2004, CIRC J, V68, P975, DOI 10.1253/circj.68.975
   Ryu So Yeon, 2008, J Prev Med Public Health, V41, P413, DOI 10.3961/jpmph.2008.41.6.413
   Saab G, 2011, CARDIORENAL MED, V1, P123, DOI 10.1159/000327149
   Saely CH, 2008, CLIN CHIM ACTA, V397, P82, DOI 10.1016/j.cca.2008.07.024
   Saisho Y, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0073430
   Salazar MR, 2013, DIABETES VASC DIS RE, V10, P346, DOI 10.1177/1479164113479809
   Saleem Muhammad Shahzad, 2011, J Ayub Med Coll Abbottabad, V23, P63
   Saleem U, 2009, J CLIN ENDOCR METAB, V94, P2558, DOI 10.1210/jc.2008-2278
   Salehidoost R, 2012, J RES MED SCI, V17, P1005
   SALONEN JT, 1988, ATHEROSCLEROSIS, V70, P155, DOI 10.1016/0021-9150(88)90109-8
   Saltevo J, 2007, MEDIAT INFLAMM, V2007, DOI 10.1155/2007/93573
   Muñoz-Torrero JFS, 2012, SOUTH MED J, V105, P339, DOI 10.1097/SMJ.0b013e31825b5fb2
   Santilli F, 2012, OBES REV, V13, P27, DOI 10.1111/j.1467-789X.2011.00930.x
   Santoro N, 2012, BIOMARK MED, V6, P719, DOI [10.2217/BMM.12.85, 10.2217/bmm.12.85]
   Santos MJ, 2009, ACTA REUMATOL PORT, V34, P590
   Satoh-Asahara N, 2011, CLIN J AM SOC NEPHRO, V6, P265, DOI 10.2215/CJN.04830610
   Sattar N, 2003, CIRCULATION, V108, P414, DOI 10.1161/01.CIR.0000080897.52664.94
   Schäffler A, 2005, BBA-GENE STRUCT EXPR, V1732, P96, DOI 10.1016/j.bbaexp.2005.11.005
   SCHALL TJ, 1994, CURR OPIN IMMUNOL, V6, P865, DOI 10.1016/0952-7915(94)90006-X
   Scheller J, 2006, MED MICROBIOL IMMUN, V195, P173, DOI 10.1007/s00430-006-0019-9
   SCHERER PE, 1995, J BIOL CHEM, V270, P26746, DOI 10.1074/jbc.270.45.26746
   Schianca GPC, 2006, DIABETES-METAB RES, V22, P111, DOI 10.1002/dmrr.560
   Schlueter N, 2014, PHARMACOL THERAPEUT, V144, P12, DOI 10.1016/j.pharmthera.2014.04.007
   Schmidt MI, 1999, LANCET, V353, P1649, DOI 10.1016/S0140-6736(99)01046-6
   Schmilovitz-Weiss H, 2012, ANN HEPATOL, V11, P343, DOI 10.1016/S1665-2681(19)30930-5
   Schönbeck U, 2001, CIRC RES, V89, P1092, DOI 10.1161/hh2401.101272
   Schwartz DR, 2011, TRENDS ENDOCRIN MET, V22, P259, DOI 10.1016/j.tem.2011.03.005
   Schwartz MW, 1996, J CLIN INVEST, V98, P1101, DOI 10.1172/JCI118891
   Schwartz MW, 1996, DIABETES, V45, P531, DOI 10.2337/diabetes.45.4.531
   Scott J, 1988, Agents Actions Suppl, V26, P27
   Sedlmeier EM, 2007, EUR J ENDOCRINOL, V156, P377, DOI 10.1530/eje.1.02345
   SELLAR GC, 1994, GENOMICS, V19, P221, DOI 10.1006/geno.1994.1051
   Sempértegui F, 2011, PUBLIC HEALTH NUTR, V14, P758, DOI 10.1017/S1368980010002636
   Servais A, 2008, AM J MED, V121, P426, DOI 10.1016/j.amjmed.2008.01.040
   Sethi JK, 2007, J LIPID RES, V48, P1253, DOI 10.1194/jlr.R700005-JLR200
   Setola E, 2004, EUR J ENDOCRINOL, V151, P483, DOI 10.1530/eje.0.1510483
   Shahid SM., 2006, Asian J Biochem, V1, P244
   Shahid SM, 2012, PAK J PHARM SCI, V25, P123
   Shantha GPS, 2009, THYROID RES, V2, DOI 10.1186/1756-6614-2-2
   Shapiro L, 1998, CURR BIOL, V8, P335, DOI 10.1016/S0960-9822(98)70133-2
   Sharifi F, 2010, INT J ENDOCRINOL MET, V8, P68
   Sharma P, 2011, INDIAN J CLIN BIOCHE, V26, P317, DOI 10.1007/s12291-011-0175-6
   Shen Y, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-124
   Shibata R, 2012, DIABETOL METAB SYNDR, V4, DOI 10.1186/1758-5996-4-37
   Shimajiri Y, 2008, DIABETES RES CLIN PR, V79, P310, DOI 10.1016/j.diabres.2007.08.026
   Siekmeier R, 2008, The Open Clinical Chemistry Journal, V1, P79
   Sierra-Johnson J, 2006, AM J CARDIOL, V98, P1369, DOI 10.1016/j.amjcard.2006.06.029
   Siervo M, 2010, J INTERN MED, V268, P338, DOI 10.1111/j.1365-2796.2010.02255.x
   Sies H, 1999, FREE RADICAL BIO MED, V27, P916, DOI 10.1016/S0891-5849(99)00177-X
   Sigurdardottir V, 2002, J INTERN MED, V252, P440, DOI 10.1046/j.1365-2796.2002.01054.x
   SIGURDSSON G, 1992, AM J CARDIOL, V69, P1251, DOI 10.1016/0002-9149(92)91215-P
   Silha JV, 2003, EUR J ENDOCRINOL, V149, P331, DOI 10.1530/eje.0.1490331
   Simeoni E, 2004, DIABETOLOGIA, V47, P1574, DOI 10.1007/s00125-004-1494-4
   Simon I, 2009, OBESITY, V17, P1124, DOI 10.1038/oby.2008.665
   Simonet WS, 1997, CELL, V89, P309, DOI 10.1016/S0092-8674(00)80209-3
   Sinha R, 2002, NEW ENGL J MED, V346, P802, DOI 10.1056/NEJMoa012578
   Sjogren P, 2005, ARTERIOSCL THROM VAS, V25, P2580, DOI 10.1161/01.ATV.0000190675.08857.3d
   Sola S, 2005, CIRCULATION, V111, P343, DOI 10.1161/01.CIR.0000153272.48711.B9
   Solymoss BC, 2003, CORONARY ARTERY DIS, V14, P207, DOI 10.1097/01.mca.0000065744.52558.9f
   Sommer DM, 2006, ARCH DERMATOL RES, V298, P321, DOI 10.1007/s00403-006-0703-z
   Soriano-Guillén L, 2004, PEDIATR RES, V55, P830, DOI 10.1203/01.PDR.0000120679.92416.70
   Soukup M, 2012, DIABETOL METAB SYNDR, V4, DOI 10.1186/1758-5996-4-14
   Moura RDSES, 2014, ARQ BRAS CARDIOL, V102, P54, DOI 10.5935/abc.20130210
   Spence JD, 2012, ARTERIOSCL THROM VAS, V32, P1550, DOI 10.1161/ATVBAHA.112.251306
   Sriharan M, 2002, DIABETES CARE, V25, P1331, DOI 10.2337/diacare.25.8.1331
   St-Pierre DH, 2007, J CLIN ENDOCR METAB, V92, P264, DOI 10.1210/jc.2006-1603
   Stalder T, 2013, J CLIN ENDOCR METAB, V98, P2573, DOI 10.1210/jc.2013-1056
   STAMPFER MJ, 1991, NEW ENGL J MED, V325, P373, DOI 10.1056/NEJM199108083250601
   Stanley TL, 2011, J CLIN ENDOCR METAB, V96, pE146, DOI 10.1210/jc.2010-1170
   Stanworth RD, 2009, FRONT HORM RES, V37, P74, DOI 10.1159/000176046
   STEINBERG D, 1964, METABOLISM, V13, P1264, DOI 10.1016/S0026-0495(64)80043-3
   STEINER G, 1980, DIABETES, V29, P899, DOI 10.2337/diabetes.29.11.899
   Stejskal D, 2008, J CLIN LAB ANAL, V22, P380, DOI 10.1002/jcla.20270
   Stejskal D, 2008, HORM METAB RES, V40, P381, DOI 10.1055/s-2008-1062746
   Stejskal D, 2006, EUR J CLIN INVEST, V36, P621, DOI 10.1111/j.1365-2362.2006.01696.x
   Stejskal D, 2010, J CLIN LAB ANAL, V24, P17, DOI 10.1002/jcla.20360
   Stenholm S, 2010, CLIN ENDOCRINOL, V73, P55, DOI 10.1111/j.1365-2265.2009.03742.x
   STOCKER R, 1987, SCIENCE, V235, P1043, DOI 10.1126/science.3029864
   Stranges S, 2005, HYPERTENSION, V46, P1186, DOI 10.1161/01.HYP.0000185688.81320.4d
   Strimbu K, 2010, CURR OPIN HIV AIDS, V5, P463, DOI 10.1097/COH.0b013e32833ed177
   Su CC, 2006, J CLIN GASTROENTEROL, V40, P551, DOI 10.1097/00004836-200607000-00015
   Succurro E, 2011, AM J CARDIOL, V107, P1650, DOI 10.1016/j.amjcard.2011.01.055
   Sudhir K, 2005, J CLIN ENDOCR METAB, V90, P3100, DOI 10.1210/jc.2004-2027
   [孙桂丽 Sun Guili], 2012, [中华内分泌代谢杂志, Chinese Journal of Endocrinology and Metabolism], V28, P211
   Sun L, 2008, J CLIN ENDOCR METAB, V93, P4690, DOI 10.1210/jc.2008-1159
   Sung KC, 2013, NUTR METAB CARDIOVAS, V23, P1239, DOI 10.1016/j.numecd.2013.02.009
   Sung KCC, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-108
   Surendar J, 2009, METAB SYNDR RELAT D, V7, P419, DOI 10.1089/met.2008.0084
   Surendar J, 2010, DIABETES TECHNOL THE, V12, P907, DOI 10.1089/dia.2010.0077
   Suriyaprom K, 2014, J MED BIOCHEM, V33, P1
   SVEGER T, 1983, ACTA PAEDIATR SCAND, V72, P499, DOI 10.1111/j.1651-2227.1983.tb09760.x
   Tahara N, 2011, ATHEROSCLEROSIS, V219, P311, DOI 10.1016/j.atherosclerosis.2011.06.022
   Takahashi H, 2010, J DERMATOL SCI, V57, P143, DOI 10.1016/j.jdermsci.2009.11.002
   TAKAHASHI K, 1987, ARCH BIOCHEM BIOPHYS, V256, P677, DOI 10.1016/0003-9861(87)90624-2
   Takayama S, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-2
   Tan BK, 2008, DIABETES, V57, P801, DOI 10.2337/db07-0990
   Tan XR, 2014, CLIN ENDOCRINOL, V81, P363, DOI 10.1111/cen.12361
   Taube A, 2012, AM J PHYSIOL-HEART C, V302, pH2148, DOI 10.1152/ajpheart.00907.2011
   Ten S, 2004, J CLIN ENDOCR METAB, V89, P2526, DOI 10.1210/jc.2004-0276
   Terra XM, 2011, EUR J ENDOCRINOL, V164, P539, DOI 10.1530/EJE-10-1195
   Tesauro M, 2009, HYPERTENSION, V54, P995, DOI 10.1161/HYPERTENSIONAHA.109.137729
   Thande N, 2009, EXPERT REV MOL DIAGN, V9, P209, DOI [10.1586/erm.09.2, 10.1586/ERM.09.2]
   Thompson AM, 2011, BMC ENDOCR DISORD, V11, DOI 10.1186/1472-6823-11-16
   Tjärnlund-Wolf A, 2012, STROKE, V43, P2833, DOI 10.1161/STROKEAHA.111.622217
   Tönjes A, 2012, INT J OBESITY, V36, P766, DOI 10.1038/ijo.2011.162
   Tombran-Tink J, 1996, Mol Vis, V2, P11
   Topsakal S, 2012, EAT WEIGHT DISORD-ST, V17, pE57, DOI 10.1007/BF03325329
   TORNVALL P, 1993, CIRCULATION, V88, P2180, DOI 10.1161/01.CIR.88.5.2180
   Trayhurn P, 1999, INT J OBESITY, V23, P22, DOI 10.1038/sj.ijo.0800791
   Tresaco B, 2005, J PHYSIOL BIOCHEM, V61, P381, DOI 10.1007/BF03167055
   Trevisan M, 2001, AM J EPIDEMIOL, V154, P348, DOI 10.1093/aje/154.4.348
   Trombini P, 2007, J HEPATOL, V46, P549, DOI 10.1016/j.jhep.2007.01.004
   Troseid M, 2010, CARDIOVASC DIABETOL, V9, DOI 10.1186/1475-2840-9-11
   Trost Susanne, 2006, Curr Diab Rep, V6, P47, DOI 10.1007/s11892-006-0052-5
   Trujillo ME, 2005, J INTERN MED, V257, P167, DOI 10.1111/j.1365-2796.2004.01426.x
   Tschoner A, 2008, OBESITY, V16, P2439, DOI 10.1038/oby.2008.391
   Tschöp M, 2001, DIABETES, V50, P707, DOI 10.2337/diabetes.50.4.707
   Tschöp M, 2001, J ENDOCRINOL INVEST, V24, pRC19, DOI 10.1007/BF03351037
   Tsimikas S, 2009, EUR HEART J, V30, P107, DOI 10.1093/eurheartj/ehn502
   Tsiotra PC, 2000, METABOLISM, V49, P1537, DOI 10.1053/meta.2000.18519
   Tsouli SG, 2006, METABOLISM, V55, P1293, DOI 10.1016/j.metabol.2006.05.013
   Tsuchiya T, 1999, EUR J PHARMACOL, V365, P273, DOI 10.1016/S0014-2999(98)00884-X
   TURK V, 1991, FEBS LETT, V285, P213, DOI 10.1016/0014-5793(91)80804-C
   Tyagi H, 2015, J PURE APPL SCI TECH, V5, P32
   Uehara SK, 2008, NUTR RES, V28, P760, DOI 10.1016/j.nutres.2008.09.006
   Ueno H, 2005, REGUL PEPTIDES, V126, P11, DOI 10.1016/j.regpep.2004.08.007
   Ukkola O, 2002, EUR J ENDOCRINOL, V147, P571, DOI 10.1530/eje.0.1470571
   Ukkola O, 2005, J CLIN ENDOCR METAB, V90, P6448
   Ukkola O, 2009, CURR PROTEIN PEPT SC, V10, P2, DOI 10.2174/138920309787315220
   Unek IT, 2010, METABOLISM, V59, P305, DOI 10.1016/j.metabol.2009.04.034
   Uotani S, 1999, DIABETES, V48, P279, DOI 10.2337/diabetes.48.2.279
   UTERMANN G, 1989, SCIENCE, V246, P904, DOI 10.1126/science.2530631
   Utzschneider KM, 2005, DIABETOLOGIA, V48, P2330, DOI 10.1007/s00125-005-1932-y
   Uygun A, 2000, AM J GASTROENTEROL, V95, P3584
   Vaidya D, 2011, EUR J CLIN NUTR, V65, P818, DOI 10.1038/ejcn.2011.47
   VALEK J, 1995, ARTERIOSCL THROM VAS, V15, P2229, DOI 10.1161/01.ATV.15.12.2229
   Van Campenhout A, 2009, ATHEROSCLEROSIS, V204, P321, DOI 10.1016/j.atherosclerosis.2008.09.033
   Van Guilder GP, 2006, OBESITY, V14, P2127, DOI 10.1038/oby.2006.248
   Vari IS, 2007, DIABETES CARE, V30, P1795, DOI 10.2337/dc06-2312
   Vasudevan AR, 2006, J CLIN ENDOCR METAB, V91, P256, DOI 10.1210/jc.2005-1280
   Vayá A, 2011, CLIN HEMORHEOL MICRO, V47, P59, DOI 10.3233/CH-2010-1366
   Venuraju SM, 2010, J AM COLL CARDIOL, V55, P2049, DOI 10.1016/j.jacc.2010.03.013
   Verhoeven V, 2015, BMC COMPLEM ALTERN M, V15, DOI 10.1186/s12906-015-0576-9
   Vessby B, 2000, BRIT J NUTR, V83, pS91
   Vessby B, 2003, CURR OPIN LIPIDOL, V14, P15, DOI 10.1097/00041433-200302000-00004
   Vidovic B, 2013, BIOL TRACE ELEM RES, V156, P22, DOI 10.1007/s12011-013-9842-1
   Vigil L, 2009, J AM SOC HYPERTENS, V3, P201, DOI 10.1016/j.jash.2009.01.002
   Viscogliosi G, 2013, METAB SYNDR RELAT D, V11, P41, DOI 10.1089/met.2012.0087
   Vítek L, 2012, FRONT PHARMACOL, V3, DOI 10.3389/fphar.2012.00055
   Vogelzangs N, 2009, AM J GERIAT PSYCHIAT, V17, P716, DOI 10.1097/JGP.0b013e3181aad5d7
   Voils SA, 2014, DIABETES METAB SYND, V8, P88, DOI 10.1016/j.dsx.2014.04.021
   Volanakis JE, 2001, MOL IMMUNOL, V38, P189, DOI 10.1016/S0161-5890(01)00042-6
   Volpert OV, 2002, NAT MED, V8, P349, DOI 10.1038/nm0402-349
   Vu A, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-4
   Vu JD, 2005, AM J CARDIOL, V96, P655, DOI 10.1016/j.amjcard.2005.04.038
   Vuksan-Cusa B, 2014, PSYCHIAT DANUB, V26, P187
   Vuksan-Cusa B, 2011, PSYCHIAT RES, V189, P21, DOI 10.1016/j.psychres.2010.11.021
   Wadhwa A, 2013, J Assoc Physicians India, V61, P384
   Walcher D, 2010, CARDIOVASC RES, V85, P167, DOI 10.1093/cvr/cvp278
   WALD NJ, 1994, LANCET, V343, P75, DOI 10.1016/S0140-6736(94)90814-1
   Wallace TM, 2004, DIABETES CARE, V27, P1487, DOI 10.2337/diacare.27.6.1487
   Wallenfeldt K, 2004, STROKE, V35, P2248, DOI 10.1161/01.STR.0000140629.65145.3c
   Wang CH, 2010, BLOOD PURIFICAT, V30, P1, DOI 10.1159/000314647
   Wang D, 2013, GENET MOL RES, V12, P5986, DOI 10.4238/2013.November.26.8
   Wang FF, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-56
   Wang GN, 2014, CLIN BIOCHEM, V47, P176, DOI 10.1016/j.clinbiochem.2014.07.013
   Wang JH, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-15
   Wang JH, 2013, DIABETOL METAB SYNDR, V5, DOI 10.1186/1758-5996-5-19
   Wang P, 2004, CELL MOL LIFE SCI, V61, P2405, DOI 10.1007/s00018-004-4256-z
   Wang P, 2008, EUR J ENDOCRINOL, V159, P713, DOI 10.1530/EJE-08-0521
   Wang QZ, 2010, INT J VITAM NUTR RES, V80, P178, DOI 10.1024/0300-9831/a000015
   Wang TJ, 2007, CIRCULATION, V115, P1345, DOI 10.1161/CIRCULATIONAHA.106.655142
   Wang Y, 2007, CLIN CHEM, V53, P34, DOI [10.1373/clinchem.2006.075614, 10.1007/s11461-007-0005-4]
   Wang YY, 2004, J DIABETES COMPLICAT, V18, P322, DOI 10.1016/S1056-8727(04)00003-0
   Wannamethee SG, 2005, ARCH INTERN MED, V165, P2644, DOI 10.1001/archinte.165.22.2644
   Wannamethee SG, 2005, DIABETES CARE, V28, P2913, DOI 10.2337/diacare.28.12.2913
   Ward AMV, 2003, CLIN ENDOCRINOL, V58, P500, DOI 10.1046/j.1365-2265.2003.01750.x
   Warensjö E, 2006, AM J CLIN NUTR, V84, P442
   Waring AC, 2012, CLIN ENDOCRINOL, V76, P911, DOI 10.1111/j.1365-2265.2011.04328.x
   Weigensberg MJ, 2008, J CLIN ENDOCR METAB, V93, P1372, DOI 10.1210/jc.2007-2309
   Weil BR, 2011, AM J PHYSIOL-HEART C, V301, pH689, DOI 10.1152/ajpheart.00206.2011
   Weiss R, 2004, NEW ENGL J MED, V350, P2362, DOI 10.1056/NEJMoa031049
   Weiss TW, 2013, METABOLISM, V62, P1008, DOI 10.1016/j.metabol.2013.01.019
   WELPLY JK, 1994, BBA-REV BIOMEMBRANES, V1197, P215, DOI 10.1016/0304-4157(94)90006-X
   WHITEHEAD AS, 1992, J BIOL CHEM, V267, P3862
   Whitfield JB, 2001, CRIT REV CL LAB SCI, V38, P263, DOI 10.1080/20014091084227
   Wiernsperger N, 2013, DIABETES METAB SYNDR, V6, P379, DOI 10.2147/DMSO.S51145
   Wierzbicki AS, 2005, HEART, V91, P1003, DOI 10.1136/hrt.2003.033092
   Wilcox Gisela, 2005, Clin Biochem Rev, V26, P19
   Wild SH, 2009, ATHEROSCLEROSIS, V203, P604, DOI 10.1016/j.atherosclerosis.2008.07.028
   WILLIAMS RF, 1968, METABOLISM, V17, P1025, DOI 10.1016/0026-0495(68)90009-7
   Windgassen EB, 2011, POSTGRAD MED, V123, P114, DOI 10.3810/pgm.2011.01.2252
   Wisse BE, 2004, J AM SOC NEPHROL, V15, P2792, DOI 10.1097/01.ASN.0000141966.69934.21
   Wiwanitkit S, 2011, ANN THORAC MED, V6, DOI 10.4103/1817-1737.84784
   Woo YC, 2013, CLIN ENDOCRINOL, V78, P489, DOI 10.1111/cen.12095
   Wozniak SE, 2009, DIGEST DIS SCI, V54, P1847, DOI 10.1007/s10620-008-0585-3
   Wu YH, 2011, J DIABETES, V3, P217, DOI 10.1111/j.1753-0407.2011.00138.x
   Wu YW, 2012, EUR J NUCL MED MOL I, V39, P399, DOI 10.1007/s00259-011-1994-7
   Xie Q, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-108
   Xu A, 2007, CIRCULATION, V115, P1537, DOI 10.1161/CIRCULATIONAHA.106.647503
   Xu AM, 2012, AM J PHYSIOL-HEART C, V302, pH1231, DOI 10.1152/ajpheart.00765.2011
   Xu AM, 2006, CLIN CHEM, V52, P405, DOI 10.1373/clinchem.2005.062463
   Yakub M, 2014, NUTRIENTS, V6, P1649, DOI 10.3390/nu6041649
   Yalniz M, 2006, MEDIAT INFLAMM, V2006, DOI 10.1155/MI/2006/34295
   Yamagishi S, 2007, INT J CARDIOL, V118, P270, DOI 10.1016/j.ijcard.2006.06.058
   Yamagishi S, 2006, J CLIN ENDOCR METAB, V91, P2447, DOI 10.1210/jc.2005-2654
   Yamaoka-Tojo M, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-3
   Yamauchi T, 2003, NATURE, V423, P762, DOI 10.1038/nature01705
   Yamawaki H, 2011, BIOCHEM BIOPH RES CO, V408, P339, DOI 10.1016/j.bbrc.2011.04.039
   Yan Eric, 2008, Metabolic Syndrome and Related Disorders, V6, P64, DOI 10.1089/met.2007.0027
   Yang KC, 2010, NUTR METAB, V7, DOI 10.1186/1743-7075-7-38
   Yang Q, 2005, NATURE, V436, P356, DOI 10.1038/nature03711
   Yang RZ, 2006, PLOS MED, V3, P884, DOI 10.1371/journal.pmed.0030287
   Yang T, 2012, ATHEROSCLEROSIS, V220, P525, DOI 10.1016/j.atherosclerosis.2011.11.014
   Yang WS, 2002, OBES RES, V10, P1104, DOI 10.1038/oby.2002.150
   Yen CH, 2013, SCI WORLD J, DOI 10.1155/2013/767968
   Yeni-Komshian H, 2000, DIABETES CARE, V23, P171, DOI 10.2337/diacare.23.2.171
   Yin JH, 2013, DIABETOL METAB SYNDR, V5, DOI 10.1186/1758-5996-5-71
   Yin QQ, 2013, J OBSTET GYNAECOL RE, V39, P203, DOI 10.1111/j.1447-0756.2012.01907.x
   Ying X, 2011, IRAN J PUBLIC HEALTH, V40, P1
   Yki-Järvinen H, 2002, J ROY SOC MED, V95, P39
   Yokota T, 2000, BLOOD, V96, P1723, DOI 10.1182/blood.V96.5.1723
   Yoo TW, 2005, CIRC J, V69, P928, DOI 10.1253/circj.69.928
   Yoshihara F, 2002, CURR OPIN CLIN NUTR, V5, P391, DOI 10.1097/00075197-200207000-00007
   Yousefzadeh G, 2012, DIABETES METAB SYND, V6, P190, DOI 10.1016/j.dsx.2012.08.013
   Yuan H, 2013, MED HYPOTHESES, V81, P969, DOI 10.1016/j.mehy.2013.08.014
   Yücel D, 2014, TURK J BIOCHEM, V39, P43, DOI 10.5505/tjb.2014.92408
   Yun JE, 2010, METABOLISM, V59, P424, DOI 10.1016/j.metabol.2009.08.012
   Yun KE, 2009, METABOLISM, V58, P798, DOI 10.1016/j.metabol.2009.01.017
   Zabel BA, 2005, J BIOL CHEM, V280, P34661, DOI 10.1074/jbc.M504868200
   Zambon A, 2005, ALIMENT PHARM THER, V22, P20, DOI 10.1111/j.1365-2036.2005.02589.x
   Zhang JH, 2008, MOL ENDOCRINOL, V22, P1416, DOI 10.1210/me.2007-0420
   Zhang JX, 2012, HUM REPROD, V27, P2484, DOI 10.1093/humrep/des191
   Zhang J, 2014, DRUG DISCOV TODAY, V19, P579, DOI 10.1016/j.drudis.2013.10.021
   Zhang X, 2008, DIABETES, V57, P1246, DOI 10.2337/db07-1476
   ZHANG YY, 1994, NATURE, V372, P425, DOI 10.1038/372425a0
   Zhong L, 2010, INFLAMMATION, V33, P353, DOI 10.1007/s10753-010-9193-4
   Zindanci I, 2012, SCI WORLD J, DOI 10.1100/2012/312463
   Zirlik A, 2007, ARTERIOSCL THROM VAS, V27, P2043, DOI 10.1161/ATVBAHA.107.149484
   Zuliani G, 2010, ATHEROSCLEROSIS, V213, P319, DOI 10.1016/j.atherosclerosis.2010.08.074
NR 953
TC 27
Z9 28
U1 1
U2 26
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD MAR 1
PY 2016
VL 14
IS 2
BP 47
EP 93
DI 10.1089/met.2015.0113
PG 47
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DG0BO
UT WOS:000371727100001
PM 26808223
DA 2025-06-11
ER

PT J
AU Vieweg, WVR
   Sood, AB
   Pandurangi, A
   Silverman, JJ
AF Vieweg, WVR
   Sood, AB
   Pandurangi, A
   Silverman, JJ
TI Application of body mass index principles in a model elementary school:
   Implications for overweight and obese children
SO JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION
LA English
DT Article
DE adolescents; anxiety; body mass index; cardiovascular disease; children;
   depression; diabetes mellitus; elementary school; Epi Info; ethnicity;
   inner-city schools; growth charts; metabolic syndrome; metabolic
   syndrome; nutstat; obesity; overweight; public school; type-2 diabetes
   mellitus
ID ADOLESCENTS; TRENDS; PREVALENCE; WEIGHT; LIFE
AB The first model elementary school in Richmond, VA formed the study site for this project. Changes in this model will lay the groundwork for changes throughout the Richmond Public School System. Of the 283 students in grades one through five, 66 students (23.3%) were randomly selected. Of the 66 students, 54 (81.8%) were black. Each student underwent height and weight measurement. Using the Nutstat module of the Centers for Disease Control (CDC) Epi Info software program available at no cost on the Internet, we identified Body Mass Index (BMI), BMI percentile for sex and age, and z-score for each student.
   Z-score measurements placed the 19 black male children at the 98.08th percentile for BMI (fewer than 2% of U.S. male children were larger). Similarly, the 35 black female children's BMI was at the 95.35th percentile (fewer than 5% of U.S. female children were larger). Based on data in the literature, the typical black male and female elementary child included in our study can expect a significant reduction in life expectancy compared with their nonobese counterparts.
C1 Virginia Commonwealth Univ, Med Coll Virginia, Dept Psychiat, Richmond, VA 23298 USA.
C3 Virginia Commonwealth University
RP Vieweg, WVR (corresponding author), 17 Runswick Dr, Richmond, VA USA.
EM vvieweg@hsc.vcu.edu
RI Lam, Raymond/D-2529-2013
CR [Anonymous], 2000, ADV DATA, V314, P1
   Chomitz VR, 2003, ARCH PEDIAT ADOL MED, V157, P765, DOI 10.1001/archpedi.157.8.765
   *DIV PUBL HLTH SUR, 2003, EPI IFO 2002 REV 2 R
   Eisenberg ME, 2003, ARCH PEDIAT ADOL MED, V157, P733, DOI 10.1001/archpedi.157.8.733
   Flegal KM, 2002, JAMA-J AM MED ASSOC, V288, P1723, DOI 10.1001/jama.288.14.1723
   Fontaine KR, 2003, JAMA-J AM MED ASSOC, V289, P187, DOI 10.1001/jama.289.2.187
   Freedman DS, 2002, JAMA-J AM MED ASSOC, V288, P1758, DOI 10.1001/jama.288.14.1758
   Krebs NF, 2003, PEDIATRICS, V112, P424, DOI 10.1542/peds.112.2.424
   MCKAY B, 2003, WALL STREET J   0820, pB1
   MUST A, 1992, NEW ENGL J MED, V327, P1350, DOI 10.1056/NEJM199211053271904
   *NATL CTR HLTH STA, 2000, CDC GROWTH CHARTS
   Ogden CL, 2002, JAMA-J AM MED ASSOC, V288, P1728, DOI 10.1001/jama.288.14.1728
   Schwimmer JB, 2003, JAMA-J AM MED ASSOC, V289, P1813, DOI 10.1001/jama.289.14.1813
   Strauss RS, 2001, JAMA-J AM MED ASSOC, V286, P2845, DOI 10.1001/jama.286.22.2845
NR 14
TC 2
Z9 2
U1 0
U2 4
PU NATL MED ASSOC
PI WASHINGON
PA 1012 10TH ST, N W, WASHINGON, DC 20001 USA
SN 0027-9684
J9 J NATL MED ASSOC
JI J. Natl. Med. Assoc.
PD APR
PY 2004
VL 96
IS 4
BP 468
EP 475
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 851DI
UT WOS:000223665200030
PM 15101667
DA 2025-06-11
ER

PT J
AU Ha, J
   Choi, DW
   Kim, KJ
   Cho, SY
   Kim, H
   Kim, KY
   Koh, Y
   Nam, CM
   Kim, E
AF Ha, Junghee
   Choi, Dong-Woo
   Kim, Kwang Joon
   Cho, So Yeon
   Kim, Hyunjeong
   Kim, Keun You
   Koh, Youngseung
   Nam, Chung Mo
   Kim, Eosu
TI Association of metformin use with Alzheimer's disease in patients with
   newly diagnosed type 2 diabetes: a population-based nested case-control
   study
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE; COGNITIVE DECLINE; RISK-FACTOR; DEMENTIA;
   DEPRESSION; MEMORY; BRAIN
AB Metformin reduces insulin resistance, which constitutes a pathophysiological connection of diabetes with Alzheimer's disease (AD), but the evidence of metformin on AD development was still insufficient and conflicting. We investigated AD risk in patients with newly diagnosed type 2 DM treated with metformin. This retrospective, observational, nested case-control study included patients with newly diagnosed type 2 DM obtained from the Korean National Health Insurance Service DM cohort (2002-2017). Among 70,499 dementia-free DM patients, 1675 AD cases were matched to 8375 controls for age, sex, and DM onset and duration. The association between AD and metformin was analyzed by multivariable regression analyses, adjusted for comorbidities and cardiometabolic risk profile. Metformin use was associated with an increased odds of AD (adjusted odds ratio [AOR] 1.50; 95% CI 1.23-1.83). The risk of AD was higher in patients with a longer DM duration. Furthermore, AD risk was significantly high in DM patients with depression (AOR 2.05; 95% CI 1.02-4.12). Given the large number of patients with DM who are taking metformin worldwide, a double-blinded, prospective study is required to determine the long-term cognitive safety of metformin.
C1 [Ha, Junghee; Cho, So Yeon; Kim, Hyunjeong; Kim, Keun You; Kim, Eosu] Yonsei Univ, Coll Med, Inst Behav Sci Med, Dept Psychiat, 50-1 Yonsei Ro, Seoul 03722, South Korea.
   [Choi, Dong-Woo] Natl Canc Ctr, Canc Big Data Ctr, Natl Canc Control Inst, Gyeonggi Do, South Korea.
   [Kim, Kwang Joon] Yonsei Univ, Coll Med, Dept Internal Med, Div Geriatr, Seoul, South Korea.
   [Cho, So Yeon; Kim, Eosu] Yonsei Univ, Coll Med, Brain Korea 21 FOUR Project Med Sci, Seoul, South Korea.
   [Koh, Youngseung] Yonsei Univ, Dept Med, Coll Med, Seoul, South Korea.
   [Nam, Chung Mo] Yonsei Univ, Coll Med, Dept Prevent Med, 50-1 Yonsei Ro, Seoul 03722, South Korea.
C3 Yonsei University; Yonsei University Health System; National Cancer
   Center - Korea (NCC); Yonsei University; Yonsei University Health
   System; Yonsei University; Yonsei University Health System; Yonsei
   University; Yonsei University Health System; Yonsei University; Yonsei
   University Health System
RP Kim, E (corresponding author), Yonsei Univ, Coll Med, Inst Behav Sci Med, Dept Psychiat, 50-1 Yonsei Ro, Seoul 03722, South Korea.; Kim, E (corresponding author), Yonsei Univ, Coll Med, Brain Korea 21 FOUR Project Med Sci, Seoul, South Korea.; Nam, CM (corresponding author), Yonsei Univ, Coll Med, Dept Prevent Med, 50-1 Yonsei Ro, Seoul 03722, South Korea.
EM cmnam@yuhs.ac; eosu.kim@yonsei.ac.kr
RI ; Kim, Keun You/ITW-0312-2023
OI Nam, Chung Mo/0000-0003-0985-0928; Ha, Junghee/0000-0002-4217-3570; Kim,
   Keun You/0000-0001-7192-2828; Kim, Eosu/0000-0001-9472-9465; Choi,
   Dong-Woo/0000-0001-5462-7579
FU Korean Association for Geriatric Psychiatry; Yonsei University College
   of Medicine [6-2018-0171]
FX This study was supported by a research grant from the Korean Association
   for Geriatric Psychiatry and a Faculty Research Grant from Yonsei
   University College of Medicine (6-2018-0171).
CR Aroda VR, 2016, J CLIN ENDOCR METAB, V101, P1754, DOI 10.1210/jc.2015-3754
   Assefa BT, 2020, BIOMED RES INT, V2020, DOI 10.1155/2020/9895121
   Barini E, 2016, MOL NEURODEGENER, V11, DOI 10.1186/s13024-016-0082-7
   Brommelhoff JA, 2009, PSYCHOL AGING, V24, P373, DOI 10.1037/a0015713
   Chen YM, 2009, P NATL ACAD SCI USA, V106, P3907, DOI 10.1073/pnas.0807991106
   Cheng C, 2014, J GERONTOL A-BIOL, V69, P1299, DOI 10.1093/gerona/glu073
   Correia S, 2008, MED CHEM, V4, P358, DOI 10.2174/157340608784872299
   Dagon Y, 2005, J BIOL CHEM, V280, P42142, DOI 10.1074/jbc.M507607200
   DiTacchio KA, 2015, J ALZHEIMERS DIS, V44, P43, DOI 10.3233/JAD-141332
   Faraone Stephen V, 2008, P T, V33, P700
   Gupta A, 2011, NEUROPHARMACOLOGY, V60, P910, DOI 10.1016/j.neuropharm.2011.01.033
   Hawley SA, 2002, DIABETES, V51, P2420, DOI 10.2337/diabetes.51.8.2420
   Imfeld P, 2012, J AM GERIATR SOC, V60, P916, DOI 10.1111/j.1532-5415.2012.03916.x
   Jorm AF, 2000, GERONTOLOGY, V46, P219, DOI 10.1159/000022163
   Kickstein E, 2010, P NATL ACAD SCI USA, V107, P21830, DOI 10.1073/pnas.0912793107
   Kim D, 2019, EUR HEART J, V40, P2313, DOI 10.1093/eurheartj/ehz386
   Kuan YC, 2017, PROG NEURO-PSYCHOPH, V79, P77, DOI 10.1016/j.pnpbp.2017.06.002
   Kuhla A, 2019, J ALZHEIMERS DIS, V68, P1415, DOI 10.3233/JAD-181017
   Labuzek K, 2010, PHARMACOL REP, V62, P956
   Ma T, 2014, J NEUROSCI, V34, P12230, DOI 10.1523/JNEUROSCI.1694-14.2014
   Mairet-Coello G, 2013, NEURON, V78, P94, DOI 10.1016/j.neuron.2013.02.003
   Moore EM, 2013, DIABETES CARE, V36, P2981, DOI 10.2337/dc13-0229
   Ng TP, 2014, J ALZHEIMERS DIS, V41, P61, DOI 10.3233/JAD-131901
   Ott A, 1999, NEUROLOGY, V53, P1937, DOI 10.1212/WNL.53.9.1937
   Pan SW, 2018, CHEST, V153, P1347, DOI 10.1016/j.chest.2017.11.040
   Porter KM, 2019, J CLIN ENDOCR METAB, V104, P4837, DOI 10.1210/jc.2018-01791
   Rasgon NL, 2011, NEUROBIOL AGING, V32, P1942, DOI 10.1016/j.neurobiolaging.2009.12.005
   Rolandsson O, 2008, DIABETES, V57, P440, DOI 10.2337/db07-1215
   Saeedi P, 2019, DIABETES RES CLIN PR, V157, DOI 10.1016/j.diabres.2019.107843
   Sluggett JK, 2020, J CLIN ENDOCR METAB, V105, DOI 10.1210/clinem/dgz234
   Steen E, 2005, J ALZHEIMERS DIS, V7, P63, DOI 10.3233/jad-2005-7107
   Sullivan MD, 2013, JAMA PSYCHIAT, V70, P1041, DOI 10.1001/jamapsychiatry.2013.1965
   Sweetman Sean., 2007, MARTINDALE COMPLETE, V35th
   Tsan YT, 2013, J CLIN ONCOL, V31, P1514, DOI 10.1200/JCO.2012.44.6831
   Tseng CH, 2019, AGING DIS, V10, P37, DOI 10.14336/AD.2017.1202
   Vingtdeux V, 2011, ACTA NEUROPATHOL, V121, P337, DOI 10.1007/s00401-010-0759-x
   WHO Collaborating Centre for Drug Statistics Methodology, 2018, ATC DDD IND
   Wu CY, 2020, ALZHEIMERS DEMENT, V16, P1663, DOI 10.1002/alz.12161
   Young BA, 2008, AM J MANAG CARE, V14, P15
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI13505
NR 40
TC 43
Z9 44
U1 1
U2 12
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 15
PY 2021
VL 11
IS 1
AR 24069
DI 10.1038/s41598-021-03406-5
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA XP2ZU
UT WOS:000730739800015
PM 34912022
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Marshe, VS
   Pira, S
   Mantere, O
   Bosche, B
   Looper, KJ
   Herrmann, N
   Müller, DJ
   Rej, S
AF Marshe, Victoria S.
   Pira, Shamira
   Mantere, Outi
   Bosche, Bert
   Looper, Karl J.
   Herrmann, Nathan
   Mueller, Daniel J.
   Rej, Soham
TI C-reactive protein and cardiovascular risk in bipolar disorder patients:
   A systematic review
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Bipolar disorder; Cardiovascular disease; Cardiovascular risk factors;
   C-reactive protein; Inflammation; Metabolic syndrome; Review
ID MAJOR DEPRESSIVE DISORDER; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   UNIPOLAR DEPRESSION; SEDENTARY BEHAVIOR; PHYSICAL-ACTIVITY; MOOD
   STABILIZERS; CYTOKINE LEVELS; OLDER-ADULTS; DISEASE
AB Objectives: New research is revealing a strong association between inflammatory markers with bipolar disorder (BD), potentially due to the high prevalence of cardiovascular disease and cardiovascular risk factors in BD. We aimed to synthesize the literature examining the association between the clinically most relevant inflammatory marker, C-reactive protein (CRP) and cardiovascular disease and cardiovascular risk factors in patients with BD.
   Methods: MEDLINE, Embase and PsychInfo were systematically searched for all relevant English language articles published prior to April 2017. Articles were included if they examined the association between CRP and cardiovascular risk factors/disease in BD.
   Results: Fifteen relevant articles were retrieved. Studies were mostly cross-sectional and heterogeneous in the cardiovascular risk factors investigated. Overall, elevated CRP was associated with increased risk of metabolic syndrome, elevated body mass index, higher waist circumference, and obesity. CRP was inconsistently associated with elevated fasting glucose, insulin levels, serum triglycerides, total cholesterol levels, and low high density lipoprotein (HDL) levels. Atypical antipsychotic use may mediate some of these effects. No study examined CRP's association with actual cardiovascular disease (e. g. coronary artery disease) in BD.
   Conclusions: In BD, CRP is associated with increases in several cardiovascular risk factors, suggesting that systemic inflammation could be a shared driving force for both outcomes of BD and cardiovascular risk. Further longitudinal research is needed in this area to verify causality, including an examination of actual cardiovascular disease. Non-pharmacological and pharmacological treatments with anti-inflammatory effects should also be investigated, particularly in patients with increased CRP, for their potential to reduce cardiovascular risk in BD.
C1 [Marshe, Victoria S.; Mueller, Daniel J.] Univ Toronto, Inst Med Sci, Fac Med, Toronto, ON, Canada.
   [Marshe, Victoria S.; Mueller, Daniel J.] Ctr Addict & Mental Hlth, Campbell Family Mental Hlth Inst, Pharmacogenet Res Clin, Toronto, ON, Canada.
   [Pira, Shamira; Looper, Karl J.; Rej, Soham] Jewish Gen Hosp, Geri PARTy Res Grp, Montreal, PQ, Canada.
   [Mantere, Outi; Looper, Karl J.; Rej, Soham] McGill Univ, Dept Psychiat, Montreal, PQ, Canada.
   [Mantere, Outi] Douglas Mental Hlth Univ Inst, Bipolar Disorders Clin, Montreal, PQ, Canada.
   [Bosche, Bert] St Michaels Hosp, Div Neurosurg, Toronto, ON, Canada.
   [Bosche, Bert] Univ Toronto, St Michaels Hosp, Li Ka Shing Knowledge Inst, Neurosci Res Program,Keenan Res Ctr, Toronto, ON, Canada.
   [Bosche, Bert] Univ Toronto, Dept Surg, Toronto, ON, Canada.
   [Bosche, Bert] Univ Duisburg Essen, Univ Hosp Essen, Dept Neurol, Essen, Germany.
   [Herrmann, Nathan] Sunnybrook Hlth Sci Ctr, Neuropsychopharmacol Res Grp, Toronto, ON, Canada.
   [Mueller, Daniel J.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
C3 University of Toronto; University of Toronto; Centre for Addiction &
   Mental Health - Canada; Jewish General Hospital - Montreal; McGill
   University; University of Toronto; Saint Michaels Hospital Toronto;
   University of Toronto; Saint Michaels Hospital Toronto; Li Ka Shing
   Knowledge Institute; University of Toronto; University of Duisburg
   Essen; University of Toronto; Sunnybrook Health Science Center;
   Sunnybrook Research Institute; University of Toronto
RP Rej, S (corresponding author), Jewish Gen Hosp, 4333 Cote Ste Catherine Rm 106, Montreal, PQ H3T 1E4, Canada.
EM soham.rej@mail.mcgill.ca
RI Bosche, Bert/AAB-7150-2020; Mueller, Daniel/GVT-7899-2022; Linnaranta
   (prev. Mantere), Outi/J-8524-2019; Mueller, Daniel/L-4159-2016
OI Bosche, Bert/0000-0002-5313-3195; Linnaranta (prev. Mantere),
   Outi/0000-0002-0383-7215; Mueller, Daniel/0000-0003-4978-4400
FU Canadian Institutes of Health Research Fellowship Award; Deutsche
   Forschungsgemeinschaft (DFG) [BO 4229/1-1, BO 4229/2-1]
FX Dr. Rej was funded by the Canadian Institutes of Health Research
   Fellowship Award. Dr. Bosche was supported by grants of the Deutsche
   Forschungsgemeinschaft (DFG; BO 4229/1-1, BO 4229/2-1).
CR [Anonymous], GENETIC RELATIONSHIP
   [Anonymous], EUR HEART J
   Bai YM, 2015, BIPOLAR DISORD, V17, P269, DOI 10.1111/bdi.12259
   Bai YM, 2014, J AFFECT DISORDERS, V166, P187, DOI 10.1016/j.jad.2014.05.009
   Baptista T, 2007, SCHIZOPHR RES, V93, P99, DOI 10.1016/j.schres.2007.03.029
   Berk M, 2011, NEUROSCI BIOBEHAV R, V35, P804, DOI 10.1016/j.neubiorev.2010.10.001
   Black S, 2004, J BIOL CHEM, V279, P48487, DOI 10.1074/jbc.R400025200
   Brietzke E, 2009, J AFFECT DISORDERS, V116, P214, DOI 10.1016/j.jad.2008.12.001
   Calkin CV, 2015, BRIT J PSYCHIAT, V206, P52, DOI 10.1192/bjp.bp.114.152850
   Calkin CV, 2013, ANN MED, V45, P171, DOI 10.3109/07853890.2012.687835
   Chang YW, 2017, J PSYCHIATR RES, V85, P29, DOI 10.1016/j.jpsychires.2016.10.021
   Chuang YC, 2012, EPILEPSIA, V53, P120, DOI 10.1111/j.1528-1167.2011.03316.x
   Correia Luis C. L., 2003, Arq. Bras. Cardiol., V81, P133, DOI 10.1590/S0066-782X2003001000002
   Correll CU, 2015, WORLD PSYCHIATRY, V14, P119, DOI 10.1002/wps.20204
   Crump C, 2013, JAMA PSYCHIAT, V70, P931, DOI 10.1001/jamapsychiatry.2013.1394
   Cunha AB, 2008, EUR ARCH PSY CLIN N, V258, P300, DOI 10.1007/s00406-007-0797-0
   Dargél AA, 2015, J CLIN PSYCHIAT, V76, P142, DOI 10.4088/JCP.14r09007
   De Berardis D, 2008, INT J IMMUNOPATH PH, V21, P319, DOI 10.1177/039463200802100208
   Diaz FJ, 2010, SCHIZOPHR RES, V121, P207, DOI 10.1016/j.schres.2010.06.002
   Dickerson F, 2007, PROG NEURO-PSYCHOPH, V31, P952, DOI 10.1016/j.pnpbp.2007.02.018
   Dickerson F, 2013, SCHIZOPHR RES, V143, P198, DOI 10.1016/j.schres.2012.10.041
   Dieset I, 2012, SCHIZOPHR RES, V140, P169, DOI 10.1016/j.schres.2012.06.040
   Dols A, 2013, INT CLIN PSYCHOPHARM, V28, P287, DOI 10.1097/YIC.0b013e32836435e2
   Fernandes BS, 2016, LANCET PSYCHIAT, V3, P1147, DOI 10.1016/S2215-0366(16)30370-4
   Ford DE, 1998, ARCH INTERN MED, V158, P1422, DOI 10.1001/archinte.158.13.1422
   Ford ES, 2002, EPIDEMIOLOGY, V13, P561, DOI 10.1097/00001648-200209000-00012
   Forty L, 2014, BRIT J PSYCHIAT, V205, P465, DOI 10.1192/bjp.bp.114.152249
   Goldstein BI, 2011, J CHILD ADOL PSYCHOP, V21, P479, DOI 10.1089/cap.2011.0009
   Goldstein BI, 2011, BIPOLAR DISORD, V13, P387, DOI 10.1111/j.1399-5618.2011.00932.x
   Goldstein BI, 2009, BIPOLAR DISORD, V11, P657, DOI 10.1111/j.1399-5618.2009.00735.x
   Hanefeld M, 2007, J AM COLL CARDIOL, V49, P290, DOI 10.1016/j.jacc.2006.08.054
   Harvey AG, 2008, AM J PSYCHIAT, V165, P820, DOI 10.1176/appi.ajp.2008.08010098
   Hayes JF, 2015, ACTA PSYCHIAT SCAND, V131, P417, DOI 10.1111/acps.12408
   Heilbronn LK, 2001, ARTERIOSCL THROM VAS, V21, P968, DOI 10.1161/01.ATV.21.6.968
   Hirschfield GM, 2003, QJM-INT J MED, V96, P793, DOI 10.1093/qjmed/hcg134
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Jialal I, 2004, HYPERTENSION, V44, P6, DOI 10.1161/01.HYP.0000130484.20501.df
   Kemp DE, 2014, CNS DRUGS, V28, P571, DOI 10.1007/s40263-014-0158-2
   Kilbourne AM, 2013, J CLIN PSYCHIAT, V74, pE655, DOI 10.4088/JCP.12m08082
   Kim SH, 2011, INT CLIN PSYCHOPHARM, V26, P43, DOI 10.1097/YIC.0b013e3283400cd3
   King DE, 2003, AM J CARDIOL, V92, P1335, DOI 10.1016/j.amjcard.2003.08.020
   Lasser K, 2000, JAMA-J AM MED ASSOC, V284, P2606, DOI 10.1001/jama.284.20.2606
   Laursen TM, 2014, PSYCHOL MED, V44, P1625, DOI 10.1017/S003329171300216X
   Leboyer M, 2012, J AFFECT DISORDERS, V141, P1, DOI 10.1016/j.jad.2011.12.049
   Lee SY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0066847
   Leopold K, 2016, J AFFECT DISORDERS, V189, P240, DOI 10.1016/j.jad.2015.09.041
   Libby P, 2006, AM J CLIN NUTR, V83, p456S
   Libby P, 2002, CIRCULATION, V105, P1135, DOI 10.1161/hc0902.104353
   Maes M, 2011, PROG NEURO-PSYCHOPH, V35, P769, DOI 10.1016/j.pnpbp.2010.06.008
   McIntyre RS, 2010, J AFFECT DISORDERS, V126, P366, DOI 10.1016/j.jad.2010.04.012
   Meier-Ewert HK, 2001, CLIN CHEM, V47, P426
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Morin-Papunen L, 2003, J CLIN ENDOCR METAB, V88, P4649, DOI 10.1210/jc.2002-021688
   Nordin G, 1996, SCAND J CLIN LAB INV, V56, P123, DOI 10.3109/00365519609088598
   O'Brien SM, 2006, BRIT J PSYCHIAT, V188, P449, DOI 10.1192/bjp.bp.105.011015
   Pasceri V, 2000, CIRCULATION, V102, P2165
   Patra J, 2015, PLOS MED, V12, DOI 10.1371/journal.pmed.1001835
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Reininghaus EZ, 2015, J AFFECT DISORDERS, V171, P33, DOI 10.1016/j.jad.2014.09.006
   Rej S, 2015, DRUG AGING, V32, P31, DOI 10.1007/s40266-014-0234-9
   Ringen PA, 2014, FRONT PSYCHIATRY, V5, DOI 10.3389/fpsyt.2014.00137
   Roberts WL, 2001, CLIN CHEM, V47, P418
   Saito I, 2014, CLIN MED INSIGHTS-CA, V8, P35, DOI 10.4137/CMC.S17066
   Sesso HD, 2003, JAMA-J AM MED ASSOC, V290, P2945, DOI 10.1001/jama.290.22.2945
   Smith EG, 2015, BRIT J PSYCHIAT, V207, P55, DOI 10.1192/bjp.bp.113.138685
   Stang A, 2010, EUR J EPIDEMIOL, V25, P603, DOI 10.1007/s10654-010-9491-z
   Stubbs B, 2015, SCHIZOPHR RES, V168, P461, DOI 10.1016/j.schres.2015.07.003
   Svendal G, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-148
   Tracy RP, 1997, ARTERIOSCL THROM VAS, V17, P2167, DOI 10.1161/01.ATV.17.10.2167
   Tsai SY, 2014, BIPOLAR DISORD, V16, P800, DOI 10.1111/bdi.12240
   Tsai SY, 2012, J AFFECT DISORDERS, V136, P110, DOI 10.1016/j.jad.2011.08.022
   Vancampfort D, 2017, PSYCHIAT RES, V256, P219, DOI 10.1016/j.psychres.2017.06.066
   Vancampfort D, 2016, J AFFECT DISORDERS, V201, P145, DOI 10.1016/j.jad.2016.05.020
   Vancampfort D, 2016, WORLD PSYCHIATRY, V15, P166, DOI 10.1002/wps.20309
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Venugopal SK, 2002, CIRCULATION, V106, P1439, DOI 10.1161/01.CIR.0000033116.22237.F9
   VIGUSHIN DM, 1993, J CLIN INVEST, V91, P1351, DOI 10.1172/JCI116336
   Vuksan-Cusa B, 2013, NORD J PSYCHIAT, V67, P320, DOI 10.3109/08039488.2012.745601
   Vuksan-Cusa B, 2010, PSYCHIAT DANUB, V22, P275
   Walker ER, 2015, JAMA PSYCHIAT, V72, P334, DOI 10.1001/jamapsychiatry.2014.2502
   Westman J, 2013, BMJ OPEN, V3, DOI 10.1136/bmjopen-2012-002373
   Wysokinski A, 2015, DIABETES METAB SYND, V9, P168, DOI 10.1016/j.dsx.2015.04.004
   Yu C, 2015, INT J GERIATR PSYCH, V30, P1114, DOI 10.1002/gps.4361
   Yudkin JS, 1999, ARTERIOSCL THROM VAS, V19, P972, DOI 10.1161/01.ATV.19.4.972
   Zwaka TP, 2001, CIRCULATION, V103, P1194
NR 85
TC 28
Z9 30
U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD OCT 3
PY 2017
VL 79
BP 442
EP 451
DI 10.1016/j.pnpbp.2017.07.026
PN B
PG 10
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA FK0BR
UT WOS:000413145700042
PM 28764912
DA 2025-06-11
ER

PT J
AU Kumar, A
   Narayanaswamy, JC
   Venkatasubramanian, G
   Raguram, R
   Grover, S
   Aswath, M
AF Kumar, Ajay
   Narayanaswamy, Janardhanan C.
   Venkatasubramanian, G.
   Raguram, R.
   Grover, Sandeep
   Aswath, Manju
TI Prevalence of metabolic syndrome and its clinical correlates among
   patients with bipolar disorder
SO ASIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Metabolic syndrome; Bipolar disorder; Correlates; Prevalence
ID NATIONAL EPIDEMIOLOGIC SURVEY; CARDIOVASCULAR RISK-FACTORS;
   PHYSICAL-ACTIVITY; RATING-SCALE; NORTH-INDIA; ALCOHOL; OBESITY;
   SCHIZOPHRENIA; DEPENDENCE; MORTALITY
AB Objective: To assess the prevalence of metabolic syndrome (MetS) in patients with bipolar disorder (BD) and examine the clinical correlates of MetS.
   Methods: Sixty-seven patients with BD were evaluated for presence for MetS. The consensus definition was used to define MetS. The clinical variables were recorded on the basis of information provided by the patients, accompanying caregivers and review of treatment records. The symptoms severity of present depressive and manic episode was assessed by using Hamilton Depression Rating Scale (HDRS) and Young Mania Rating Scale (YMRS) respectively.
   Results: The prevalence of MetS was 53.7%. Patients with MetS were older than the patients with BD alone (P=0.001). Increased waist circumference was the most common abnormal parameter (74.6%) followed by low high density lipoprotein (HDL) (71.6%) and raised triglycerides (64.2%). High blood pressures were recorded in 35.8% with high fasting blood glucose levels were seen in 33.3%. MetS was associated with greater number of life time episodes (p=0.010), longer duration of illness (p=0.010), greater numbers of lifetime depressive episodes (p < 0.001). Substance use (alcohol and nicotine) associated with significantly higher prevalence of high blood pressure among MetS patients (p < 0.001) while abnormal triglyceride level shown associated with substance use (p=0.010). Age of the patients, number of lifetime depressive episodes and use of Olanzapine were found to predictive of the development of MetS.
   Conclusions: Patients with BD have high prevalence of MetS and its presence correlates with clinical variables. (C) 2017 Elsevier B.V. All rights reserved.
C1 [Kumar, Ajay; Grover, Sandeep] PGIMER, Dept Psychiat, Chandigarh, India.
   [Narayanaswamy, Janardhanan C.; Venkatasubramanian, G.] NIMHANS, Dept Psychiat, Bangalore, Karnataka, India.
   [Raguram, R.; Aswath, Manju] KIMS, Bangalore, Karnataka, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh; National Institute of Mental Health & Neurosciences - India;
   Kempegowda Institute of Medical Sciences (KIMS)
RP Kumar, A (corresponding author), PGIMER, Dept Psychiat, Chandigarh, India.
EM ak_pal2000@yahoo.com; jairamnimhans@gmail.com; venkat.nimhans@yahoo.com;
   profraguram@gmal.com; drsandeepg2002@yahoo.com; manjuaswath@yahoo.com
RI Venkatasubramanian, Ganesan/AAD-9117-2019; Kumar, Dr Ajay/AAG-4580-2020
OI Venkatasubramanian, Ganesan/0000-0002-0949-898X; Kumar, Dr
   Ajay/0000-0003-0391-3836; Grover, Sandeep/0000-0002-2714-2055
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Altman K. W., INT J CARE PATHWAYS, V16, P33, DOI [10.1258/jicp.2012.012m01, DOI 10.1258/JICP.2012.012M01]
   Angst F, 2002, J AFFECT DISORDERS, V68, P167, DOI 10.1016/S0165-0327(01)00377-9
   [Anonymous], PRIM PSYCHIAT
   BRADY KT, 1992, J CLIN PSYCHOPHARM, V12, pS17, DOI 10.1097/00004714-199202001-00004
   Chang HH, 2009, J AFFECT DISORDERS, V117, P124, DOI 10.1016/j.jad.2008.12.018
   Chengappa KNR, 2000, BIPOLAR DISORD, V2, P191, DOI 10.1034/j.1399-5618.2000.020306.x
   Elmslie JL, 2001, J CLIN PSYCHIAT, V62, P486, DOI 10.4088/JCP.v62n0614
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   Fagiolini A, 2003, AM J PSYCHIAT, V160, P112, DOI 10.1176/appi.ajp.160.1.112
   Ford ES, 2005, OBES RES, V13, P608, DOI 10.1038/oby.2005.65
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   Garcia-Portilla MP, 2008, J AFFECT DISORDERS, V106, P197, DOI 10.1016/j.jad.2007.06.002
   Grant BF, 2004, ARCH GEN PSYCHIAT, V61, P1107, DOI 10.1001/archpsyc.61.11.1107
   Grant BF, 2004, ARCH GEN PSYCHIAT, V61, P807, DOI 10.1001/archpsyc.61.8.807
   Grover S, 2014, ASIAN J PSYCHIATR, V10, P51, DOI 10.1016/j.ajp.2014.03.004
   Grover S, 2014, NORD J PSYCHIAT, V68, P72, DOI 10.3109/08039488.2012.754052
   Grover Sandeep, 2012, Indian J Psychol Med, V34, P110, DOI 10.4103/0253-7176.101767
   Grover S, 2012, PROG NEURO-PSYCHOPH, V36, P141, DOI 10.1016/j.pnpbp.2011.10.013
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Klumpers UMH, 2004, PHARMACOPSYCHIATRY, V37, P211, DOI 10.1055/s-2004-832594
   Lakka TA, 2005, HANDB EXP PHARM, V170, P137
   Malhotra N, 2013, J AFFECT DISORDERS, V150, P653, DOI 10.1016/j.jad.2013.03.010
   McIntyre RS, 2010, ADV THER, V27, P828, DOI 10.1007/s12325-010-0072-z
   Ösby U, 2001, ARCH GEN PSYCHIAT, V58, P844, DOI 10.1001/archpsyc.58.9.844
   Pini S, 2005, EUR NEUROPSYCHOPHARM, V15, P425, DOI 10.1016/j.euroneuro.2005.04.011
   Salvi V, 2008, GEN HOSP PSYCHIAT, V30, P318, DOI 10.1016/j.genhosppsych.2008.04.009
   van Winkel R, 2008, BIPOLAR DISORD, V10, P342, DOI 10.1111/j.1399-5618.2007.00520.x
   YOUNG RC, 1978, BRIT J PSYCHIAT, V133, P429, DOI 10.1192/bjp.133.5.429
NR 30
TC 17
Z9 20
U1 0
U2 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1876-2018
EI 1876-2026
J9 ASIAN J PSYCHIATR
JI Asian J. Psychiatr.
PD APR
PY 2017
VL 26
BP 109
EP 114
DI 10.1016/j.ajp.2017.01.020
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA EY8ZO
UT WOS:000404288300026
PM 28483070
DA 2025-06-11
ER

PT J
AU Mirahmadi, M
   Aghasizadeh, M
   Nazifkar, F
   Choubdari, MG
   Assaran-Darban, R
   Tavallaie, S
   Hatamzadeh, H
   Ferns, GA
   Mirinezhad, MR
   Baharara, H
   Hadizadeh, F
   Ghayour-Mobarhan, M
AF Mirahmadi, Mahdi
   Aghasizadeh, Malihe
   Nazifkar, Fatemeh
   Choubdari, Mahla Ghafarian
   Assaran-Darban, Reza
   Tavallaie, Shima
   Hatamzadeh, Hossein
   Ferns, Gordon A.
   Mirinezhad, Mohammad Reza
   Baharara, Hamed
   Hadizadeh, Farzin
   Ghayour-Mobarhan, Majid
TI The Effects of Lycopene on Modulating Oxidative Stress and Liver Enzymes
   Levels in Metabolic Syndrome Patients: A Randomised Clinical Trial
SO CELL JOURNAL
LA English
DT Article
DE Inflammation; Liver Enzyme; Lycopene; Metabolic Syndrome; Oxidative
   Stress
ID TOMATO; DISEASE; ANTIOXIDANT; EXTRACTION
AB Objective: The pathogenesis of metabolic syndrome (MetS) complications involves the excessive production of reactive oxygen species, inflammation, and endothelial dysfunction. Due to Lycopene, a highly unstable structure and its significant effects on modulating the metabolic system, there is a strong need for a formula that can increase its stability. The aim of this study was to develop an approach for encapsulating Lycopene and investigate its effects on inflammatory markers, oxidative stress, and liver enzymes in patients with MetS.Materials and Methods: This study is a simple randomized, double-blind, objective-based clinical trial that involved eighty subjects with MetS, who were equally and randomly assigned to two groups: one group received 20 mg of Lycopene per day for 8 weeks, and the Placebo group followed the same protocol as the Lycopene group but received a placebo instead of Lycopene. They were called Lycopene and placebo, respectively. During follow-up visits after 4 and 8 weeks, 20 ml of blood was collected for evaluation of liver enzymes and some inflammatory related markers.Results: Prior to the assignment of volunteers to their respective groups, there were no notable differences in C-reactive protein (CRP), serum liver enzymes, systolic and diastolic blood pressure, or pro-oxidant-antioxidant balance (PAB) between the Lycopene and placebo groups. However, our subsequent analysis revealed a significant reduction in the serum levels of CRP (P=0.001) and PAB (P=0.004) in the group that received Lycopene. Our encapsulated Lycopene treatment was not associated with a significant difference in serum levels of alanine aminotransferase (ALT), aspartate transferase (AST), or alkaline phosphatase (ALP) between our two groups.Conclusion: This study investigated the impact of Lycopene on individuals with MetS, revealing a noteworthy modulation effect on PAB and inflammation linked to MetS. However, no significant differences was demonstrated in serum levels of ALT, AST and ALP between the studied group (registration number: IRCT20130507013263N3).
C1 [Mirahmadi, Mahdi; Hadizadeh, Farzin] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, POB 99199-91766, Mashhad, Iran.
   [Aghasizadeh, Malihe; Tavallaie, Shima; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Int UNESCO Ctr Hlth Related Basic Sci & Human Nutr, POB 99199-91766, Mashhad, Iran.
   [Nazifkar, Fatemeh; Choubdari, Mahla Ghafarian; Assaran-Darban, Reza] Islamic Azad Univ, Dept Biol, Mashhad Branch, Mashhad, Iran.
   [Hatamzadeh, Hossein] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Iran.
   [Ferns, Gordon A.] Brighton & Sussex Med Sch, Div Med Educ, Brighton, England.
   [Mirinezhad, Mohammad Reza] Mashhad Univ Med Sci, Fac Med, Dept Med Genet, Mashhad, Iran.
   [Baharara, Hamed] Mashhad Univ Med Sci, Sch Pharm, Dept Clin Pharm, Mashhad, Iran.
   [Hadizadeh, Farzin] Mashhad Univ Med Sci, Sch Pharm, Dept Med Chem, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Islamic Azad University; Mashhad University of Medical
   Sciences; University of Brighton; University of Sussex; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences;
   Mashhad University of Medical Sciences
RP Hadizadeh, F (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, POB 99199-91766, Mashhad, Iran.; Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Int UNESCO Ctr Hlth Related Basic Sci & Human Nutr, POB 99199-91766, Mashhad, Iran.
EM hadizadehf@mums.ac.ir; ghayourm@mums.ac.ir
RI Ghayour-Mobarhan, Majid/AAY-5963-2020; Hadizadeh, Farzin/AAG-2067-2019;
   Assaran Draban, Reza/S-3572-2017
OI Aghasizadeh, Malihe/0000-0001-8562-360X
FU Mashhad University of Medical Sciences [960774]
FX This project was implemented in collaboration with Mashhad University of
   Medical Sciences (grant number: 960774). The authors would like to
   gratefully acknowledge the contribution of participants in the study.
   The authors declare that they have no conflicts of interest in this
   study
CR Abenavoli L, 2022, J CLIN MED, V11, DOI 10.3390/jcm11123477
   Ahmadnezhad M, 2018, BIOFACTORS, V44, P263, DOI 10.1002/biof.1424
   Alamdari DH, 2007, CLIN BIOCHEM, V40, P248, DOI 10.1016/j.clinbiochem.2006.10.017
   Ambroselli D, 2023, NUTRIENTS, V15, DOI 10.3390/nu15030640
   Andersen LF, 2006, BRIT J NUTR, V95, P358, DOI 10.1079/BJN20051638
   Bahcecioglu Ibrahim Halil, 2010, Vet Med Int, V2010, DOI 10.4061/2010/262179
   Baz L, 2022, MOLECULES, V27, DOI 10.3390/molecules27227736
   Briones-Labarca V, 2019, FOOD CHEM, V278, P751, DOI 10.1016/j.foodchem.2018.11.106
   Caseiro M, 2020, LWT-FOOD SCI TECHNOL, V127, DOI 10.1016/j.lwt.2020.109323
   Elimam H, 2019, DIABETES METAB SYND, V13, P800, DOI 10.1016/j.dsx.2018.11.061
   Ghazizadeh H., 2020, Obes Med, V19, P100272, DOI [10.1016/j.obmed.2020.100272, DOI 10.1016/J.OBMED.2020.100272]
   Grabowska M, 2019, FOOD FUNCT, V10, P3090, DOI [10.1039/C9FO00580C, 10.1039/c9fo00580c]
   Hadad N, 2012, FREE RADICAL BIO MED, V53, P1381, DOI 10.1016/j.freeradbiomed.2012.07.078
   Huang H, 2023, NUTR REV, V81, P939, DOI 10.1093/nutrit/nuad009
   Jiang W, 2016, WORLD J GASTROENTERO, V22, P10180, DOI 10.3748/wjg.v22.i46.10180
   Kelkel M, 2011, FREE RADICAL RES, V45, P925, DOI 10.3109/10715762.2011.564168
   Khalesi M, 2016, J PEDIATR GASTR NUTR, V62, P276, DOI 10.1097/MPG.0000000000000917
   Kim OY, 2010, ATHEROSCLEROSIS, V208, P581, DOI 10.1016/j.atherosclerosis.2009.08.009
   Lioudaki E, 2011, CURR PHARM DESIGN, V17, P3632, DOI 10.2174/138161211798220945
   Negri R, 2020, J CLIN MED, V9, DOI 10.3390/jcm9010141
   Nosková K, 2020, PHARMACOL REP, V72, P156, DOI 10.1007/s43440-019-00007-y
   Oda E, 2018, CLIN DERMATOL, V36, P3, DOI 10.1016/j.clindermatol.2017.09.002
   Pandey P, 2021, NUTR RES, V92, P21, DOI 10.1016/j.nutres.2021.05.011
   Periago MJ, 2004, J AGR FOOD CHEM, V52, P5796, DOI 10.1021/jf049345h
   Poojary MM, 2015, FOOD CHEM, V173, P943, DOI 10.1016/j.foodchem.2014.10.127
   Richelle M, 2010, BRIT J NUTR, V103, P1800, DOI 10.1017/S0007114510000103
   Saawarn Nisheeth, 2011, Indian J Dent Res, V22, P639, DOI 10.4103/0970-9290.93448
   Seki E, 2012, GASTROENTEROLOGY, V143, P307, DOI 10.1053/j.gastro.2012.06.004
   Senkus KE, 2019, ADV NUTR, V10, P19, DOI 10.1093/advances/nmy069
   Srivastava S, 2015, J FOOD SCI TECH MYS, V52, P41, DOI 10.1007/s13197-012-0918-2
   Sun BC, 2012, J HEPATOL, V56, P704, DOI 10.1016/j.jhep.2011.09.020
   Swiatkiewicz I, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24076382
   Xing Y, 2021, J AGR FOOD CHEM, V69, P9822, DOI 10.1021/acs.jafc.1c04194
   Zafari N, 2022, LIFE SCI, V305, DOI 10.1016/j.lfs.2022.120760
   Zamani M, 2023, CURR PHARM DESIGN, V29, P1671, DOI 10.2174/1381612829666230726112510
   Zielinska MA, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010193
   Zujko ME, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12020362
   Zuorro A, 2020, MOLECULES, V25, DOI 10.3390/molecules25092038
NR 38
TC 8
Z9 8
U1 0
U2 0
PU ROYAN INST
PI TEHRAN
PA PO BOX 19395-4644, TEHRAN, 00000, IRAN
SN 2228-5806
EI 2228-5814
J9 CELL J
JI Cell J.
PD DEC
PY 2023
VL 25
IS 12
BP 847
EP 853
DI 10.22074/CELLJ.2023.2006158.1353
PG 7
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA FI1R2
UT WOS:001145046200007
PM 38192255
DA 2025-06-11
ER

PT J
AU Hayden, MR
   Yang, Y
   Habibi, J
   Bagree, SV
   Sowers, JR
AF Hayden, Melvin R.
   Yang, Ying
   Habibi, Javad
   Bagree, Sarika V.
   Sowers, James R.
TI Pericytopathy Oxidative stress and impaired cellular longevity in the
   pancreas and skeletal muscle in metabolic syndrome and type 2 diabetes
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
DE adult mesenchymal stem cells; antipericyte autoantibodies; apoptosis;
   beta cells; islet amyloid; islet fibrosis; rarefaction; reactive oxygen
   species
ID GLYCATION END-PRODUCTS; MESENCHYMAL STEM-CELLS; HIP RAT MODEL;
   INSULIN-RESISTANCE; MICROVASCULAR PERICYTES; INTRAMURAL PERICYTES;
   ELECTRON-MICROSCOPY; VASCULAR-DISEASE; MELLITUS; RETINOPATHY
AB The pericyte's role has been extensively studied in retinal tissues of diabetic retinopathy; however, little is known regarding its role in such tissues as the pancreas and skeletal muscle. This supportive microvascular mural cell plays an important and novel role in cellular and extracellular matrix remodeling in the pancreas and skeletal muscle of young rodent models representing the metabolic syndrome and type 2 diabetes mellitus (T2DM). Transmission electron microscopy can be used to evaluate these tissues from young rodent models of insulin resistance and T2DM, including the transgenic Ren2 rat, db/db obese insulin resistant-T2DM mouse, and human islet amyloid polypeptide (HIP) rat model of T2DM. With this method, the earliest pancreatic remodeling change was widening of the islet exocrine interface and pericyte hypercellularity, followed by pericyte differentiation into islet and pancreatic stellate cells with early fibrosis involving the islet exocrine interface and interlobular interstitium. In skeletal muscle there was a unique endothelial capillary connectivity via elongated longitudinal pericyte processes in addition to pericyte to pericyte and pericyte to myocyte cell-cell connections allowing for paracrine communication. Initial pericyte activation due to moderate oxidative stress signaling may be followed by hyperplasia, migration and differentiation into adult mesenchymal cells. Continued robust oxidative stress may induce pericyte apoptosis and impaired cellular longevity. Circulating antipericyte autoantibodies have recently been characterized, and may provide a screening method to detect those patients who are developing pericyte loss and are at greater risk for the development of complications of T2DM due to pericytopathy and rarefaction. Once detected, these patients may be offered more aggressive treatment strategies such as early pharmacotherapy in addition to lifestyle changes targeted to maintaining pericyte integrity. In conclusion, we have provided a review of current knowledge regarding the pericyte and novel ultrastructural findings regarding its role in metabolic syndrome and T2DM.
C1 [Hayden, Melvin R.; Yang, Ying; Habibi, Javad; Sowers, James R.] Univ Missouri, Sch Med, Dept Internal Med, Kunming, Peoples R China.
   [Sowers, James R.] Yunnan Prov 2nd Hosp, Dept Physiol, Kunming, Peoples R China.
   [Yang, Ying; Habibi, Javad; Sowers, James R.] Yunnan Prov 2nd Hosp, Dept Pharmacol, Kunming, Peoples R China.
   [Hayden, Melvin R.; Yang, Ying; Habibi, Javad; Bagree, Sarika V.; Sowers, James R.] Yunnan Prov 2nd Hosp, Harry S Truman VA Med Ctr, Kunming, Peoples R China.
   [Yang, Ying] Yunnan Prov 2nd Hosp, Diabet Cardiovasc Ctr, Kunming, Peoples R China.
RP Hayden, MR (corresponding author), Univ Missouri, Sch Med, Dept Internal Med, Kunming, Peoples R China.
EM mrh29@usmo.com
FU NIH [R01 HL73101-01A1]; Veterans Affairs Merit System [0018]
FX This research was supported by NIH (R01 HL73101-01A1), Veterans Affairs
   Merit System 0018 (J.R.S.).
CR ADDISON DJ, 1970, BRIT MED J, V1, P264, DOI 10.1136/bmj.1.5691.264
   Allt G, 2001, CELLS TISSUES ORGANS, V169, P1, DOI 10.1159/000047855
   Armulik A, 2005, CIRC RES, V97, P512, DOI 10.1161/01.RES.0000182903.16652.d7
   ASHTON N, 1966, BRIT J OPHTHALMOL, V50, P119, DOI 10.1136/bjo.50.3.119
   Attia SM, 2010, OXID MED CELL LONGEV, V3, P238, DOI 10.4161/oxim.3.4.13246
   Bouayed J, 2010, OXID MED CELL LONGEV, V3, P228, DOI 10.4161/oxim.3.4.12858
   Brignardello E, 1998, J ENDOCRINOL, V158, P21, DOI 10.1677/joe.0.1580021
   Caplan AI, 2008, CELL STEM CELL, V3, P229, DOI 10.1016/j.stem.2008.08.008
   Corcoran MP, 2007, AM J CLIN NUTR, V85, P662
   Creager MA, 2003, CIRCULATION, V108, P1527, DOI 10.1161/01.CIR.0000091257.27563.32
   Crisan M, 2008, CELL STEM CELL, V3, P301, DOI 10.1016/j.stem.2008.07.003
   Meirelles LDS, 2006, J CELL SCI, V119, P2204, DOI 10.1242/jcs.02932
   Davidoff MS, 2004, J CELL BIOL, V167, P935, DOI 10.1083/jcb.200409107
   DEFRONZO RA, 1985, J CLIN INVEST, V76, P149, DOI 10.1172/JCI111938
   DEFRONZO RA, 1988, DIABETES, V37, P667, DOI 10.2337/diab.37.6.667
   Dellavalle A, 2007, NAT CELL BIOL, V9, P255, DOI 10.1038/ncb1542
   Doherty MJ, 1998, J BONE MINER RES, V13, P828, DOI 10.1359/jbmr.1998.13.5.828
   Donath MY, 2008, DIABETES CARE, V31, pS161, DOI 10.2337/dc08-s243
   Dore-Duffy P, 2006, J CEREBR BLOOD F MET, V26, P613, DOI 10.1038/sj.jcbfm.9600272
   Ehses JA, 2007, DIABETES, V56, P2356, DOI 10.2337/db06-1650
   FARQUHAR MG, 1956, ANAT REC, V124, P288
   Farrington-Rock C, 2004, CIRCULATION, V110, P2226, DOI 10.1161/01.CIR.0000144457.55518.E5
   Gerhardt H, 2003, CELL TISSUE RES, V314, P15, DOI 10.1007/s00441-003-0745-x
   Habibi J, 2008, ENDOCRINOLOGY, V149, P5643, DOI 10.1210/en.2008-0070
   Hayden MR, 2007, J PANCREAS, V8, P725
   Hayden MR, 2008, EXP BIOL MED, V233, P1109, DOI 10.3181/0709-RM-251
   Hayden MR, 2007, EXP BIOL MED, V232, P772
   Hayden Melvin R, 2007, J Cardiometab Syndr, V2, P70, DOI 10.1111/j.1559-4564.2007.06159.x
   Hayden MR, 2007, ANTIOXID REDOX SIGN, V9, P891, DOI 10.1089/ars.2007.1610
   Hayden MR, 2007, ANTIOXID REDOX SIGN, V9, P865, DOI 10.1089/ars.2007.1640
   Hayden MR, 2005, CARDIOVASC DIABETOL, V4, DOI 10.1186/1475-2840-4-4
   Hayden MR, 2003, CARDIOVASC DIABETOL, V2, DOI 10.1186/1475-2840-2-2
   Hayden Melvin R, 2008, J Cardiometab Syndr, V3, P234, DOI 10.1111/j.1559-4572.2008.00024.x
   Hurst RT, 2003, ANN INTERN MED, V139, P824, DOI 10.7326/0003-4819-139-10-200311180-00010
   Jonk AM, 2007, PHYSIOLOGY, V22, P252, DOI 10.1152/physiol.00012.2007
   KELLEY C, 1987, J CELL BIOL, V104, P483, DOI 10.1083/jcb.104.3.483
   Kim JW, 2008, FRONT BIOSCI-LANDMRK, V13, P6022, DOI 10.2741/3133
   KUWABARA T, 1961, ARCH OPHTHALMOL-CHIC, V65, P708, DOI 10.1001/archopht.1961.01840020710019
   LILLIOJA S, 1987, J CLIN INVEST, V80, P415, DOI 10.1172/JCI113088
   Maiese Kenneth, 2008, Expert Rev Cardiovasc Ther, V6, P281, DOI 10.1586/14779072.6.3.281
   Maiese K, 2010, OXID MED CELL LONGEV, V3, P227, DOI 10.4161/oxim.3.4.13340
   Nakamura M, 1995, DIABETES RES CLIN PR, V30, P89, DOI 10.1016/0168-8227(95)01155-2
   Nayak RC, 2003, DIABETOLOGIA, V46, P511, DOI 10.1007/s00125-003-1057-0
   Ozerdem U, 2005, INVEST OPHTH VIS SCI, V46, P3502, DOI 10.1167/iovs.05-0309
   Rajantie I, 2004, BLOOD, V104, P2084, DOI 10.1182/blood-2004-01-0336
   Ritov VB, 2005, DIABETES, V54, P8, DOI 10.2337/diabetes.54.1.8
   Rouget C., 1873, Archive Physiologie Normale Pathologique, V5, P603
   SHEPRO D, 1993, FASEB J, V7, P1031, DOI 10.1096/fasebj.7.11.8370472
   SIMS DE, 1986, TISSUE CELL, V18, P153, DOI 10.1016/0040-8166(86)90026-1
   SPEISER P, 1968, ARCH OPHTHALMOL-CHIC, V80, P332, DOI 10.1001/archopht.1968.00980050334007
   Tahara N, 2010, OXID MED CELL LONGEV, V3, P262, DOI 10.4161/oxim.3.4.12734
   TILTON RG, 1979, MICROVASC RES, V18, P325, DOI 10.1016/0026-2862(79)90041-4
   TILTON RG, 1981, DIABETES, V30, P326, DOI 10.2337/diab.30.4.326
   Yamagishi S, 2005, FEBS LETT, V579, P4265, DOI 10.1016/j.febslet.2005.06.058
   Yamagishi S, 2010, OXID MED CELL LONGEV, V3, P101, DOI 10.4161/oxim.3.2.11148
   YANOFF M, 1966, NEW ENGL J MED, V274, P1344, DOI 10.1056/NEJM196606162742403
   Zhao HL, 2003, DIABETES, V52, P2759, DOI 10.2337/diabetes.52.11.2759
   Zierath JR, 2004, PLOS BIOL, V2, P1523, DOI 10.1371/journal.pbio.0020348
   Zimmermann K.W., 1923, Z Anat Entwicklungsgesch, V68, P3, DOI DOI 10.1007/978-3-642-92456-9
NR 59
TC 37
Z9 42
U1 3
U2 10
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1942-0900
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD SEP-OCT
PY 2010
VL 3
IS 5
BP 290
EP 303
DI 10.4161/oxim.3.5.13653
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 716TI
UT WOS:000286996000002
PM 21150342
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Sadabadi, F
   Darroudi, S
   Esmaily, H
   Asadi, Z
   Ferns, GA
   Mohammadpour, AH
   Nooriyan, AH
   Ghayour-Mobarhan, M
   Moohebati, M
AF Sadabadi, Fatemeh
   Darroudi, Susan
   Esmaily, Habibollah
   Asadi, Zahra
   Ferns, Gordon A.
   Mohammadpour, Amir Hooshang
   Nooriyan, Amir Hossein
   Ghayour-Mobarhan, Majid
   Moohebati, Mohsen
TI The importance of sleep patterns in the incidence of coronary heart
   disease: a 6-year prospective study in Mashhad, Iran
SO SCIENTIFIC REPORTS
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; INSOMNIA SYMPTOMS; RISK; DURATION; METAANALYSIS;
   ASSOCIATION; MASHAD
AB Chronic shortened sleep can increase several cardiovascular risk factors, including depression, anxiety, metabolic syndrome, diabetes and hypertension. In the current study, we aimed to investigate the relationship between sleep patterns and the incidence of coronary heart disease (CHD). A total of 9704 healthy participants were recruited for the MASHAD cohort study. Within 6 years of follow-up, participants were categorized into four groups based on their number of hours of nightly sleep. Cox's proportional hazard model was used to assess relative risks (RRs) and 95% confidence intervals (CIs). During the study, 235 heart problems, including myocardial infarction, stable angina and unstable angina, were confirmed. There were significant differences between men and women who had short and long nightly sleep (p < 0.05). The incidence of CHD was significantly higher in participants with very short night sleep durations than in those with longer hours of night sleep. The subjects with very short nightly sleep were more susceptible to unstable angina (RR: 2.614 (CI 1.354-5.047)) (p < 0.05). We found that shortened nightly sleep was associated with an increased incidence of coronary heart disease in an Iranian population. These findings suggest that sleep disorders, especially shortened night sleep, can be a risk factor for CHD.
C1 [Sadabadi, Fatemeh; Darroudi, Susan; Asadi, Zahra; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Int UNESCO Ctr Hlth, Related Basic Sci & Human Nutr, Mashhad, Iran.
   [Esmaily, Habibollah] Mashhad Univ Med Sci, Social Determinants Hlth Res Ctr, Mashhad, Iran.
   [Ferns, Gordon A.] Brighton & Sussex Med Sch, Div Med Educ, Falmer, Brighton BN1 9PH, Sussex, England.
   [Mohammadpour, Amir Hooshang] Mashhad Univ Med Sci, Pharmaceut Inst Technol, Pharmaceut Res Ctr, Mashhad, Iran.
   [Mohammadpour, Amir Hooshang] Mashhad Univ Med Sci, Sch Pharm, Dept Clin Pharm, Mashhad, Iran.
   [Nooriyan, Amir Hossein] Islamic Azad Univ Mashhad, Mashhad, Iran.
   [Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Sch Med, Mashhad 9919991766, Iran.
   [Moohebati, Mohsen] Mashhad Univ Med Sci, Cardiovasc Res Ctr, Sch Med, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; University of Brighton; University of Sussex; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences;
   Islamic Azad University; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences
RP Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Int UNESCO Ctr Hlth, Related Basic Sci & Human Nutr, Mashhad, Iran.; Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Sch Med, Mashhad 9919991766, Iran.; Moohebati, M (corresponding author), Mashhad Univ Med Sci, Cardiovasc Res Ctr, Sch Med, Mashhad, Iran.
EM ghayourm@mums.ac.ir; mouhebatim@mums.ac.ir
RI Ghayour-Mobarhan, Majid/AAY-5963-2020; mohebati, mohsen/AAR-2016-2021
CR Baglioni C, 2011, J AFFECT DISORDERS, V135, P10, DOI 10.1016/j.jad.2011.01.011
   Bertisch SM, 2018, SLEEP, V41, DOI 10.1093/sleep/zsy047
   Buxton OM, 2010, DIABETES, V59, P2126, DOI 10.2337/db09-0699
   Carreras A, 2014, SLEEP, V37, P1817, DOI 10.5665/sleep.4178
   Chao CY, 2011, METABOLISM, V60, P799, DOI 10.1016/j.metabol.2010.07.031
   Clark AJ, 2016, SLEEP, V39, P1709, DOI 10.5665/sleep.6098
   Collins GS, 2012, BRIT MED J, V344, DOI 10.1136/bmj.e4181
   Darroudi S, 2021, INT J PUBLIC HEALTH, V66, DOI 10.3389/ijph.2021.633183
   Darroudi S, 2018, J CLIN LAB ANAL, V32, DOI 10.1002/jcla.22579
   Fan MY, 2020, EUR HEART J, V41, P1182, DOI 10.1093/eurheartj/ehz849
   Feige B, 2008, J SLEEP RES, V17, P180, DOI 10.1111/j.1365-2869.2008.00651.x
   Ferrie JE, 2015, DIABETES CARE, V38, P1467, DOI 10.2337/dc15-0186
   Ghayour-Mobarhan M, 2015, INT J PUBLIC HEALTH, V60, P561, DOI 10.1007/s00038-015-0679-6
   Grandner MA, 2016, CURR OPIN CARDIOL, V31, P551, DOI 10.1097/HCO.0000000000000324
   Grandner MA, 2014, SLEEP MED, V15, P42, DOI 10.1016/j.sleep.2013.09.012
   Khan MS, 2017, SLEEP MED CLIN, V12, P167, DOI 10.1016/j.jsmc.2017.01.005
   Kowall B, 2016, SLEEP MED, V21, P35, DOI 10.1016/j.sleep.2015.12.017
   Krittanawong C, 2019, EUR HEART J-ACUTE CA, V8, P762, DOI 10.1177/2048872617741733
   Kwok CS, 2018, J AM HEART ASSOC, V7, DOI 10.1161/JAHA.118.008552
   Lanfranchi PA, 2009, SLEEP, V32, P760, DOI 10.1093/sleep/32.6.760
   Li M, 2014, INT J CARDIOL, V176, P1044, DOI 10.1016/j.ijcard.2014.07.284
   Li YP, 2014, CIRCULATION, V129, P737, DOI 10.1161/CIRCULATIONAHA.113.004500
   Meng L, 2013, HYPERTENS RES, V36, P985, DOI 10.1038/hr.2013.70
   Morovatdar Negar, 2019, J Atr Fibrillation, V11, P2132, DOI 10.4022/jafib.2132
   Poorzand H, 2019, EUR J CLIN INVEST, V49, DOI 10.1111/eci.13124
   Sadabadi F, 2020, REP BIOCHEM MOL BIOL, V9, P64, DOI 10.29252/rbmb.9.1.64
   Sofi F, 2014, EUR J PREV CARDIOL, V21, P57, DOI 10.1177/2047487312460020
   Spiegelhalder K, 2010, NAT SCI SLEEP, V2, P71
   Troxel WM, 2010, SLEEP, V33, P1633, DOI 10.1093/sleep/33.12.1633
   Vozoris NT, 2013, J HYPERTENS, V31, P663, DOI 10.1097/HJH.0b013e32835ed5d0
   Zhou T, 2022, J INTERN MED, V291, P64, DOI 10.1111/joim.13367
NR 31
TC 3
Z9 3
U1 0
U2 6
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD FEB 18
PY 2023
VL 13
IS 1
AR 2903
DI 10.1038/s41598-023-29451-w
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 9S9NK
UT WOS:000946661900025
PM 36806201
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Narbutt, J
   Niedzwiedz, M
   Lesiak, A
   Ceryn, J
   Skibinska, M
AF Narbutt, Joanna
   Niedzwiedz, Michal
   Lesiak, Aleksandra
   Ceryn, Justyna
   Skibinska, Malgorzata
TI Secukinumab for the Treatment of Psoriasis in Pediatrics: Patient
   Selection and Acceptability
SO PATIENT PREFERENCE AND ADHERENCE
LA English
DT Review
DE pediatric psoriasis; psoriasis vulgaris; secukinumab; acceptability
ID SYSTEMIC TREATMENT; ATOPIC-DERMATITIS; EXPERIENCE; MANAGEMENT; DISEASES;
   INDEX; IL-17
AB Psoriasis (PsO) is a chronic, systemic, immune-mediated inflammatory skin disease affecting 1% to 5% population worldwide. In one-third of patients, the first symptoms of PsO manifest in childhood, with a mean age of nine years. Psoriasis in children under 16 years of age constitutes 4% of dermatological problems in this age group. Chronic inflammation of the skin observed in PsO is associated with a development of potentially serious comorbidities, including psoriatic arthritis, hypertension, metabolic syndrome, cardiovascular diseases, inflammatory bowel disease, depression and anxiety. It is reported that among children with psoriasis between 5 and 16 years of age health-related quality of life is reduced by 30.5%. Early diagnosis and effective treatment are crucial in pediatric psoriatic patients to avoid future complications and stigmatization. Treatment for psoriasis consists of a range of topical medications, phototherapy and non-biologic and biologic systemic therapies. Approved biologics for PsO in pediatric patients include etanercept, adalimumab, ustekinumab, ixekizumab and secukinumab. Secukinumab, a recombinant, fully human monoclonal antibody targeting IL-17A, was approved by the EMA (2020) and FDA (2021) in pediatric patients above 6 years of age for the treatment of moderate to severe plaque psoriasis who are candidates for systemic therapy. This review discusses the selection and acceptability of secukinumab in children with psoriasis.
C1 [Narbutt, Joanna; Niedzwiedz, Michal; Lesiak, Aleksandra; Ceryn, Justyna; Skibinska, Malgorzata] Med Univ Lodz, Dept Dermatol Pediat Dermatol & Dermatol Oncol, Lodz, Poland.
   [Ceryn, Justyna] Med Univ Lodz, Int Doctoral Sch, Lodz, Poland.
   [Niedzwiedz, Michal] Med Univ Lodz, Dept Dermatol Pediat Dermatol & Oncol, Gen Karola Kniaziewicza 1-5, PL-91347 Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz; Medical University
   Lodz
RP Niedzwiedz, M (corresponding author), Med Univ Lodz, Dept Dermatol Pediat Dermatol & Dermatol Oncol, Lodz, Poland.; Niedzwiedz, M (corresponding author), Med Univ Lodz, Dept Dermatol Pediat Dermatol & Oncol, Gen Karola Kniaziewicza 1-5, PL-91347 Lodz, Poland.
EM michal.niedzwiedz@umed.lodz.pl
RI Niedźwiedź, Michał/KBA-4159-2024; Lesiak, Aleksandra/S-9634-2016;
   Niedzwiedz, Michal/GRY-6089-2022
OI Niedzwiedz, Michal/0000-0002-9322-629X; Skibinska,
   Malgorzata/0000-0001-9264-5751; Ceryn, Justyna/0000-0001-8969-6814;
   Lesiak, Aleksandra/0000-0003-3318-729X
FU  [503/5-064-04/503-01]
FX Funding This research was funded by statutory activity no.
   503/5-064-04/503-01 (Medical University of Lodz) .
CR Akimzhanov AM, 2007, J BIOL CHEM, V282, P5969, DOI 10.1074/jbc.C600322200
   Albela H, 2022, J DERMATOL TREAT, V33, P1769, DOI 10.1080/09546634.2021.1899111
   Arican O, 2005, MEDIAT INFLAMM, P273, DOI 10.1155/MI.2005.273
   Atak MF, 2022, PEDIATR DERMATOL, V39, P49, DOI 10.1111/pde.14896
   Bardowska K, 2022, EXPERT OPIN DRUG SAF, V21, P867, DOI 10.1080/14740338.2022.2073349
   Basra MKA, 2013, BRIT J DERMATOL, V169, P760, DOI 10.1111/bjd.12563
   Blair HA, 2021, PEDIATR DRUGS, V23, P601, DOI 10.1007/s40272-021-00476-w
   Blauvelt A, 2018, CLIN REV ALLERG IMMU, V55, P379, DOI 10.1007/s12016-018-8702-3
   Bodemer C, 2021, J EUR ACAD DERMATOL, V35, P938, DOI 10.1111/jdv.17002
   Brembilla NC, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01682
   Bruins FM, 2020, JAMA DERMATOL, V156, P72, DOI 10.1001/jamadermatol.2019.3717
   Brunner HI, 2023, ANN RHEUM DIS, V82, P154, DOI 10.1136/ard-2022-222849
   Burden-Teh E, 2022, BRIT J DERMATOL, V186, P341, DOI 10.1111/bjd.20689
   Cai XC, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.896550
   Cheng BT, 2021, J AM ACAD DERMATOL, V85, P885, DOI 10.1016/j.jaad.2021.02.069
   Craiglow BG, 2018, J AM ACAD DERMATOL, V79, P487, DOI 10.1016/j.jaad.2018.02.034
   Dalgard FJ, 2015, J INVEST DERMATOL, V135, P984, DOI 10.1038/jid.2014.530
   Datta Debatri, 2021, J Clin Aesthet Dermatol, V14, pS19
   Di Lernia V, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.847308
   Diotallevi F, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms231911128
   Diotallevi F, 2022, NUTRIENTS, V14, DOI 10.3390/nu14030591
   Eichenfield LF, 2017, J ALLERGY CLIN IMMUN, V139, pS49, DOI 10.1016/j.jaci.2017.01.009
   Elder JT, 2010, J INVEST DERMATOL, V130, P1213, DOI 10.1038/jid.2009.319
   Eshwar V, 2022, PHARMACEUTICALS-BASE, V15, DOI 10.3390/ph15111365
   Fisher S, 2021, INT J DERMATOL, V60, P1429, DOI 10.1111/ijd.15679
   Gaffen SL, 2009, NAT REV IMMUNOL, V9, P556, DOI 10.1038/nri2586
   Galecka M, 2021, J PERS MED, V11, DOI 10.3390/jpm11020066
   Golhen K, 2022, FRONT MED-LAUSANNE, V9, DOI 10.3389/fmed.2022.944208
   Gottlieb AB, 2022, ACTA DERM-VENEREOL, V102, DOI 10.2340/actadv.v102.563
   Griffiths CEM, 2021, LANCET, V397, P1301, DOI 10.1016/S0140-6736(20)32549-6
   Hebert AA, 2022, J DERMATOL TREAT, V33, P2433, DOI 10.1080/09546634.2022.2059051
   Hou RH, 2021, CHINESE MED J-PEKING, V134, P2644, DOI 10.1097/CM9.0000000000001801
   Huang IH, 2022, J DTSCH DERMATOL GES, V20, P1201, DOI 10.1111/ddg.14832
   Kara T, 2019, J DERMATOL TREAT, V30, P129, DOI 10.1080/09546634.2018.1476653
   Kaushik SB, 2019, J AM ACAD DERMATOL, V80, P43, DOI 10.1016/j.jaad.2018.06.056
   Kelly KA, 2021, CHILDREN-BASEL, V8, DOI 10.3390/children8111057
   Köstner K, 2018, RHEUMATOLOGY, V57, P936, DOI 10.1093/rheumatology/kex510
   Langley RGB, 2015, J DERMATOL TREAT, V26, P23, DOI 10.3109/09546634.2013.865009
   Lavaud J, 2019, ANN DERMATOL VENER, V146, P771, DOI 10.1016/j.annder.2019.03.007
   Lebwohl MG, 2016, AM J CLIN DERMATOL, V17, P87, DOI 10.1007/s40257-015-0169-x
   Lefferdink R, 2023, ARCH DERMATOL RES, V315, P305, DOI 10.1007/s00403-022-02325-3
   Magnolo N, 2022, PEDIATR DRUGS, V24, P377, DOI 10.1007/s40272-022-00507-0
   Magnolo N, 2022, J AM ACAD DERMATOL, V86, P122, DOI 10.1016/j.jaad.2021.08.066
   Marques E, 2021, INT J CLIN PRACT, V75, DOI 10.1111/ijcp.14915
   Meehan EV, 2022, GENES-BASEL, V13, DOI 10.3390/genes13091643
   Menter A, 2020, J AM ACAD DERMATOL, V82, P161, DOI 10.1016/j.jaad.2019.08.049
   Narbutt J, 2021, PRZEGL DERMATOL 2, V108, P335, DOI [10.5114/DR.2021.111962, DOI 10.5114/DR.2021.111962]
   Narbutt J, 2021, PRZ DERMATOL, V108, P239, DOI 10.5114/dr.2021.110913
   Nast A, 2021, J EUR ACAD DERMATOL, V35, P281, DOI 10.1111/jdv.16926
   NICE, SEC TREAT MOD SEV PL
   Nishida M, 2020, J DERMATOL, V47, pE77, DOI 10.1111/1346-8138.15228
   Nourmohammadpour P, 2022, PEDIATR DERMATOL, V39, P211, DOI 10.1111/pde.14891
   Peris K, 2022, DERMATOLOGY THER, V12, P1753, DOI 10.1007/s13555-022-00758-2
   Ruan SF, 2023, J AM ACAD DERMATOL, V88, P243, DOI 10.1016/j.jaad.2022.04.064
   Sadowska M, 2022, POSTEP DERM ALERGOL, V39, P34, DOI 10.5114/ada.2020.98558
   Sahin G, 2021, ARCH IRAN MED, V24, P903, DOI 10.34172/aim.2021.135
   Salek MS, 2013, BRIT J DERMATOL, V169, P734, DOI 10.1111/bjd.12437
   Martín MS, 2020, PEDIATR DERMATOL, V37, P952, DOI 10.1111/pde.14228
   Schaap MJ, 2022, J DERMATOL TREAT, V33, P2527, DOI 10.1080/09546634.2021.1985058
   Schneeweiss MC, 2020, J AM ACAD DERMATOL, V82, P1337, DOI 10.1016/j.jaad.2020.02.065
   Sekhon M, 2017, BMC HEALTH SERV RES, V17, DOI 10.1186/s12913-017-2031-8
   Seyger MMB, 2022, ACTA DERM-VENEREOL, V102, DOI 10.2340/actadv.v101.981
   Shah Vibhuti, 2015, Clin J Pain, V31, pS38, DOI 10.1097/AJP.0000000000000281
   Sticherling M, 2022, DERMATOLOGY THER, V12, P1793, DOI 10.1007/s13555-022-00761-7
   Subramani D, 2022, CLIN EXP DERMATOL, V47, P2288, DOI 10.1111/ced.15373
   Sun HY, 2022, PEDIATR DERMATOL, V39, P42, DOI 10.1111/pde.14870
   Takeshita J, 2017, J AM ACAD DERMATOL, V76, P377, DOI 10.1016/j.jaad.2016.07.064
   Veith WB, 2011, MINERVA PEDIATR, V63, P327
   von Stebut E, 2019, J INVEST DERMATOL, V139, P1054, DOI 10.1016/j.jid.2018.10.042
   Wierzbowska-Drabik K, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms221910402
   Zamberk P, 2010, J EUR ACAD DERMATOL, V24, P415, DOI 10.1111/j.1468-3083.2009.03425.x
NR 71
TC 7
Z9 8
U1 2
U2 19
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1177-889X
J9 PATIENT PREFER ADHER
JI Patient Prefer. Adherence
PY 2023
VL 17
BP 421
EP 431
DI 10.2147/PPA.S350753
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA C8PM4
UT WOS:000964473200001
PM 36815128
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Scott, D
   Burke, K
   Williams, S
   Happell, B
   Canoy, D
   Ronan, K
AF Scott, David
   Burke, Karena
   Williams, Susan
   Happell, Brenda
   Canoy, Doreen
   Ronan, Kevin
TI Increased prevalence of chronic physical health disorders in Australians
   with diagnosed mental illness
SO AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH
LA English
DT Article
DE mental disorders; chronic disease; obesity; comorbidity
ID METABOLIC SYNDROME; PEOPLE; SCHIZOPHRENIA; DEPRESSION; MORTALITY;
   DISEASE; ANXIETY; CANCER; DEATH; RISK
AB Objective: To compare chronic physical health disorder prevalence amongst Australian adults with and without mental illness. Method: Total n=1,716 participants (58% female) with a mean age of 52 +/- 13 years (range: 18 to 89 years) completed an online survey of Australian adults in 2010. Outcome measures including prevalence of chronic physical conditions and self-reported body mass index (BMI) in n=387 (23%) with a self-reported mental illness diagnosis were compared to respondents without mental illness. Results: A significantly higher proportion of participants with mental illness were obese (BMI = 30; 31 vs 24%, p=0.005). Adjusted odds ratios (OR) for coronary heart disease, diabetes, chronic bronchitis or emphysema, asthma, irritable bowel syndrome, and food allergies or intolerances (OR range: 1.543.19) demonstrated that chronic physical disorders were significantly more common in participants with a mental illness. Conclusion: Australian adults with a diagnosis for mental illness have a significantly increased likelihood of demonstrating chronic physical health disorders compared to persons without mental illness. Implications: Health professionals must be alert to the increased likelihood of comorbid chronic physical disorders in persons with a mental illness and should consider the adoption of holistic approaches when treating those with either a mental or physical illness.
C1 [Scott, David; Burke, Karena; Williams, Susan; Happell, Brenda; Canoy, Doreen; Ronan, Kevin] CQUniv, Inst Hlth & Social Sci Res, Rockhampton, Qld 4702, Australia.
C3 Central Queensland University
RP Scott, D (corresponding author), CQUniv, Inst Hlth & Social Sci Res, Bldg 18, Rockhampton, Qld 4702, Australia.
EM d.scott@cqu.edu.au
RI Scott, David/AAE-5031-2021; Burke, Karena/ABG-2775-2020; Happell,
   Brenda/HSI-0570-2023
OI Happell, Brenda/0000-0002-7293-6583; Ronan, Kevin/0000-0002-2698-5886;
   Burke, Professor Karena J./0000-0002-3754-076X; Scott,
   David/0000-0001-5226-1972
CR [Anonymous], 2010, AUSTR HLTH 2010
   Australian Bureau of Statistics, 2008, 4326 0 NAT SURV MENT
   Australian Bureau of Statistics, 2009, 8146 0 HOUS US INF T, P2008
   Australian Bureau of Statistics, 2006, CENS 2006
   Bushara KO, 2005, GASTROENTEROLOGY, V128, pS92, DOI 10.1053/j.gastro.2005.02.018
   Carney CP, 2004, PSYCHOSOM MED, V66, P735, DOI 10.1097/01.psy.0000133281.10749.64
   Cohen D, 2006, EUR NEUROPSYCHOPHARM, V16, P187, DOI 10.1016/j.euroneuro.2005.09.003
   Davidson S, 2001, AUST NZ J PSYCHIAT, V35, P196, DOI 10.1046/j.1440-1614.2001.00877.x
   Himelhoch S, 2004, AM J PSYCHIAT, V161, P2317, DOI 10.1176/appi.ajp.161.12.2317
   Howard Patricia B, 2007, Issues Ment Health Nurs, V28, P255, DOI 10.1080/01612840601172593
   John AP, 2009, MED J AUSTRALIA, V190, P176, DOI 10.5694/j.1326-5377.2009.tb02342.x
   Lawrence DM, 2003, BRIT J PSYCHIAT, V182, P31, DOI 10.1192/bjp.182.1.31
   Lee S, 2009, ALIMENT PHARM THER, V30, P643, DOI 10.1111/j.1365-2036.2009.04074.x
   Leucht S, 2007, ACTA PSYCHIAT SCAND, V116, P317, DOI 10.1111/j.1600-0447.2007.01095.x
   McConnell S, 2005, INT J PSYCHIAT CLIN, V9, P157, DOI 10.1080/13651500510029138
   Osborn DPJ, 2007, ARCH GEN PSYCHIAT, V64, P242, DOI 10.1001/archpsyc.64.2.242
   Ösby U, 2000, SCHIZOPHR RES, V45, P21, DOI 10.1016/S0920-9964(99)00191-7
   Scott David, 2011, Issues Ment Health Nurs, V32, P589, DOI 10.3109/01612840.2011.569846
   Tirupati S, 2007, AUST NZ J PSYCHIAT, V41, P606, DOI 10.1080/00048670701392841
   Zhao G, 2009, INT J OBESITY, V33, P257, DOI 10.1038/ijo.2008.268
NR 20
TC 27
Z9 28
U1 0
U2 42
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1326-0200
EI 1753-6405
J9 AUST NZ J PUBL HEAL
JI Aust. N. Z. Publ. Health
PD OCT
PY 2012
VL 36
IS 5
BP 483
EP 486
DI 10.1111/j.1753-6405.2012.00916.x
PG 4
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 014XN
UT WOS:000309409200017
PM 23025372
OA Bronze
DA 2025-06-11
ER

PT J
AU Kakouri, NS
   Thomopoulos, CG
   Siafi, EP
   Valatsou, AE
   Dimitriadis, KS
   Mani, IP
   Patsilinakos, SP
   Tousoulis, DM
   Tsioufis, KP
AF Kakouri, Niki S.
   Thomopoulos, Costas G.
   Siafi, Eirini P.
   Valatsou, Angeliki E.
   Dimitriadis, Kyriakos S.
   Mani, Iliana P.
   Patsilinakos, Sotirios P.
   Tousoulis, Dimitrios M.
   Tsioufis, Konstantinos P.
TI Overview of the Association Between Non-Alcoholic Fatty Liver Disease
   and Hypertension
SO CARDIOLOGY DISCOVERY
LA English
DT Review
DE Hypertension; Non-alcoholic fatty liver disease; Insulin resistance;
   Sympathetic nervous system; Metabolic syndrome
ID RENIN-ANGIOTENSIN SYSTEM; INSULIN-RESISTANCE; BLOOD-PRESSURE; FOLLOW-UP;
   STEATOHEPATITIS; FIBROSIS; OBESITY; RISK; INHIBITION; STEATOSIS
AB Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and its prevalence is rising. NAFLD is closely associated with metabolic syndrome, with both conditions sharing common clinical characteristics such as obesity, insulin resistance, type 2 diabetes mellitus, hypertension, and hypertriglyceridemia. Several observational studies have evaluated the relationship between NAFLD and hypertension, with the overall evidence suggesting a bidirectional relationship. It is hypothesized that activation of the sympathetic nervous and renin-angiotensin systems, observed in NAFLD with or without insulin resistance promotes the development of hypertension. In patients with hypertension, activation of these systems can lead to hepatic fibrosis and progressive inflammation through increased oxidative stress and activation of hepatic stellate cells and Kupffer cells. The present review examines the pathophysiologic and clinical evidence supporting the bidirectional association between NAFLD and hypertension.
C1 [Kakouri, Niki S.; Siafi, Eirini P.; Valatsou, Angeliki E.; Dimitriadis, Kyriakos S.; Mani, Iliana P.; Tousoulis, Dimitrios M.; Tsioufis, Konstantinos P.] Natl & Kapodistrian Univ Athens, Hippokrat Hosp, Med Sch, Dept Cardiol 1, Athens 11527, Greece.
   [Thomopoulos, Costas G.] Elena Venizelou Hosp, Dept Cardiol, Athens 11521, Greece.
   [Patsilinakos, Sotirios P.] Gen Hosp Agia Olga, Dept Cardiol, Athens 14233, Greece.
C3 National & Kapodistrian University of Athens; Hippokration General
   Hospital; General Hospital of N. Ionia Agia Olga
RP Tsioufis, KP (corresponding author), Natl & Kapodistrian Univ Athens, Hippokrat Hosp, Med Sch, Dept Cardiol 1, Athens 11527, Greece.
EM ktsioufis@hippocratio.gr
RI Thomopoulos, Costas/ABF-1156-2021
CR Aizawa-Abe M, 2000, J CLIN INVEST, V105, P1243, DOI 10.1172/JCI8341
   Aneni EC, 2015, J HYPERTENS, V33, P1207, DOI 10.1097/HJH.0000000000000532
   Angulo P, 2007, HEPATOLOGY, V45, P846, DOI 10.1002/hep.21496
   Artunc F, 2016, NAT REV NEPHROL, V12, P721, DOI 10.1038/nrneph.2016.145
   Ballestri S, 2017, METABOLISM, V72, P57, DOI 10.1016/j.metabol.2017.04.003
   Bedogni G, 2014, WORLD J GASTROENTERO, V20, P9050, DOI 10.3748/wjg.v20.i27.9050
   Byrne CD, 2018, BMJ-BRIT MED J, V362, DOI 10.1136/bmj.k2734
   Cai DS, 2005, NAT MED, V11, P183, DOI 10.1038/nm1166
   Castéra L, 2010, HEPATOLOGY, V51, P828, DOI 10.1002/hep.23425
   Charlton MR, 2011, GASTROENTEROLOGY, V141, P1249, DOI 10.1053/j.gastro.2011.06.061
   DiBona GF, 2010, AM J PHYSIOL-REG I, V298, pR245, DOI 10.1152/ajpregu.00647.2009
   Feng RN, 2014, WORLD J GASTROENTERO, V20, P17932, DOI 10.3748/wjg.v20.i47.17932
   Flaa A, 2008, METABOLISM, V57, P1422, DOI 10.1016/j.metabol.2008.05.012
   Goh GB, 2015, LIVER INT, V35, P979, DOI 10.1111/liv.12611
   Harrison SA, 2008, GUT, V57, P1441, DOI 10.1136/gut.2007.146019
   Hernaez R, 2011, HEPATOLOGY, V54, P1082, DOI 10.1002/hep.24452
   Hoffman RP, 1999, J DIABETES COMPLICAT, V13, P17, DOI 10.1016/S1056-8727(98)00019-1
   Huh JH, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0143560
   Jonsson JR, 2001, GASTROENTEROLOGY, V121, P148, DOI 10.1053/gast.2001.25480
   Kato J, 2012, INT J MOL MED, V30, P107, DOI 10.3892/ijmm.2012.958
   Kuwashiro S, 2011, CELL TISSUE RES, V344, P125, DOI 10.1007/s00441-011-1132-7
   Kuzminova NV, 2016, ARTER HYPERTENS, V20, P216, DOI 10.5603/AH.2016.0025
   Lau K, 2010, J HYPERTENS, V28, P1829, DOI 10.1097/HJH.0b013e32833c211b
   Li Yating, 2018, Oncotarget, V9, P24155, DOI 10.18632/oncotarget.23816
   Lim S, 2015, INT J CARDIOL, V201, P408, DOI 10.1016/j.ijcard.2015.08.107
   Lonardo A, 2018, J HEPATOL, V68, P335, DOI 10.1016/j.jhep.2017.09.021
   Lonardo A, 2015, DIGEST LIVER DIS, V47, P181, DOI 10.1016/j.dld.2014.09.020
   Long MT, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0157517
   Long M, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0126714
   Loomba R, 2013, NAT REV GASTRO HEPAT, V10, P686, DOI 10.1038/nrgastro.2013.171
   Lorbeer R, 2017, J HYPERTENS, V35, P737, DOI 10.1097/HJH.0000000000001245
   Ma JT, 2017, J HEPATOL, V66, P390, DOI 10.1016/j.jhep.2016.09.022
   Machado MV, 2014, WORLD J GASTROENTERO, V20, P12956, DOI 10.3748/wjg.v20.i36.12956
   Marchesini G, 2017, J HEPATOL, V66, P466, DOI 10.1016/j.jhep.2016.11.002
   McPherson S, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0175717
   Morris EM, 2013, MOL CELL ENDOCRINOL, V378, P29, DOI 10.1016/j.mce.2012.04.013
   Munshi MK, 2011, EXP BIOL MED, V236, P557, DOI 10.1258/ebm.2011.010375
   Obici S, 2002, NAT NEUROSCI, V5, P566, DOI 10.1038/nn861
   Obici S, 2002, NAT MED, V8, P1376, DOI 10.1038/nm798
   Qian LY, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000004293
   Ratziu V, 2005, GASTROENTEROLOGY, V128, P1898, DOI 10.1053/j.gastro.2005.03.084
   Rojas E, 2014, CURR HYPERTENS REP, V16, DOI 10.1007/s11906-014-0463-7
   Ryoo JH, 2014, J GASTROEN HEPATOL, V29, P1926, DOI 10.1111/jgh.12643
   Ryoo JH, 2014, J KOREAN MED SCI, V29, P973, DOI 10.3346/jkms.2014.29.7.973
   Saadeh S, 2002, GASTROENTEROLOGY, V123, P745, DOI 10.1053/gast.2002.35354
   Sabath E, 2015, OBES REV, V16, P871, DOI 10.1111/obr.12308
   Shim KY, 2018, KOREAN J INTERN MED, V33, P453, DOI 10.3904/kjim.2017.317
   Sigala B, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0072928
   Singh S, 2015, CLIN GASTROENTEROL H, V13, P643, DOI 10.1016/j.cgh.2014.04.014
   Sorrentino P, 2010, AM J GASTROENTEROL, V105, P336, DOI 10.1038/ajg.2009.587
   Sun W, 2015, QJM-INT J MED, V108, P617, DOI 10.1093/qjmed/hcv006
   Sung KC, 2014, J HEPATOL, V60, P1040, DOI 10.1016/j.jhep.2014.01.009
   Tsuneto A, 2010, HYPERTENS RES, V33, P638, DOI 10.1038/hr.2010.45
   van den Hoek AM, 2004, DIABETES, V53, P2529, DOI 10.2337/diabetes.53.10.2529
   Vernon G, 2011, ALIMENT PHARM THER, V34, P274, DOI 10.1111/j.1365-2036.2011.04724.x
   Wang YH, 2016, HEPATOL RES, V46, P1304, DOI 10.1111/hepr.12688
   Yamamoto E, 2008, HYPERTENSION, V52, P573, DOI 10.1161/HYPERTENSIONAHA.108.112292
   Yang S, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0224626
   Yokohama S, 2004, HEPATOLOGY, V40, P1222, DOI 10.1002/hep.20420
   Yoo HJ, 2015, DIABETES METAB J, V39, P10, DOI 10.4093/dmj.2015.39.1.10
   Younossi ZM, 2012, MEDICINE, V91, P319, DOI 10.1097/MD.0b013e3182779d49
   Zhang T, 2015, ATHEROSCLEROSIS, V240, P144, DOI 10.1016/j.atherosclerosis.2015.02.049
   Zhang YY, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2015-008204
   Zois CD, 2010, WORLD J GASTROENTERO, V16, P3944, DOI 10.3748/wjg.v16.i31.3944
NR 64
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2096-952X
EI 2693-8499
J9 CARDIOL DISCOV
JI Cardiol. Discov.
PD MAR
PY 2024
VL 4
IS 1
BP 30
EP 37
DI 10.1097/CD9.0000000000000113
PG 8
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA K2K9A
UT WOS:001342227800007
OA gold
DA 2025-06-11
ER

PT J
AU Xu, HY
   Zhuang, XY
AF Xu, Haiyun
   Zhuang, Xiaoyin
TI Atypical antipsychotics-induced metabolic syndrome and nonalcoholic
   fatty liver disease: a critical review
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Review
DE antipsychotics; MetS; NAFLD; schizophrenia
ID INDUCED WEIGHT-GAIN; INDUCED HEPATIC STEATOSIS; OLANZAPINE TREATMENT;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; DOUBLE-BLIND;
   CARDIOVASCULAR-DISEASE; GLUCOSE-HOMEOSTASIS; ANTIOXIDANT ENZYMES;
   CLOZAPINE TREATMENT
AB The atypical antipsychotics (AAPs) have been used as first-line drugs in psychiatric practice for a wide range of psychotic disorders, including schizophrenia and bipolar mania While effectively exerting therapeutic effects on positive and negative symptoms, as well as cognitive impairments in schizophrenia patients, these drugs are less likely to induce extrapyramidal symptoms compared to typical antipsychotics. However, the increasing application of them has raised questions on their tolerability and adverse effects over the endocrine, metabolic, and cardiovascular axes. Specifically, AAPs are associated to different extents, with weight gain, metabolic syndrome (MetS), and nonalcoholic fatty liver disease (NAFLD). This article summarized clinical evidence showing the metabolic side effects of AAPs in patients with schizophrenia, and experimental evidence of AAPs-induced metabolic side effects observed in animals and cell culture studies. In addition, it discussed potential mechanisms involved in the APPs-induced MetS and NAFLD.
C1 [Xu, Haiyun; Zhuang, Xiaoyin] Shantou Univ, Med Coll, Mental Hlth Ctr, Shantou 515041, Peoples R China.
C3 Shantou University
RP Xu, HY (corresponding author), Shantou Univ, Med Coll, Mental Hlth Ctr, Shantou 515041, Peoples R China.
EM hyxu@stu.edu.cn
RI Xu, Haiyun/AFL-1251-2022; zhuang, xiaoyin/LRT-4619-2024
OI Xu, Haiyun/0000-0002-0752-6502; Zhuang, Xiaoyin/0000-0001-5172-260X
CR Araya J, 2004, CLIN SCI, V106, P635, DOI 10.1042/CS20030326
   Ardizzone TD, 2001, BRAIN RES, V923, P82, DOI 10.1016/S0006-8993(01)03026-8
   Atmaca M, 2003, J CLIN PSYCHIAT, V64, P598, DOI 10.4088/JCP.v64n0516
   Azorin JM, 2006, INT CLIN PSYCHOPHARM, V21, P49, DOI 10.1097/01.yic.0000177020.26311.a7
   Baig MR, 2010, J PSYCHIATR PRACT, V16, P325, DOI 10.1097/01.pra.0000388627.36781.6a
   BAKER GF, 1972, BIOCHEM PHARMACOL, V21, P1871, DOI 10.1016/0006-2952(72)90183-9
   Balt SL, 2011, CLIN PHARMACOL THER, V90, P179, DOI 10.1038/clpt.2011.97
   Baptista T, 2002, BRAIN RES, V957, P144, DOI 10.1016/S0006-8993(02)03616-8
   Baptista T, 1999, ACTA PSYCHIAT SCAND, V100, P3, DOI 10.1111/j.1600-0447.1999.tb10908.x
   Barahal HS, 1946, PSYCHIAT QUART, V20, P31
   Bartoli F, 2015, EUR NEUROPSYCHOPHARM, V25, P1767, DOI 10.1016/j.euroneuro.2015.06.011
   Beaulieu JM, 2005, CELL, V122, P261, DOI 10.1016/j.cell.2005.05.012
   Bilgic S, 2017, BRATISL MED J, V118, P618, DOI 10.4149/BLL_2017_119
   Boyda HN, 2010, TRENDS PHARMACOL SCI, V31, P484, DOI 10.1016/j.tips.2010.07.002
   Bulua AC, 2011, J EXP MED, V208, P519, DOI 10.1084/jem.20102049
   Burrows T, 2011, INT J PEDIATR OBES, V6, pE532, DOI 10.3109/17477166.2010.549489
   Cai HL, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.161
   Canfrán-Duque A, 2013, J LIPID RES, V54, P310, DOI 10.1194/jlr.M026948
   Caniato RN, 2006, AUST NZ J PSYCHIAT, V40, P691, DOI 10.1111/j.1440-1614.2006.01869.x
   Carbon M, 2017, J CLIN PSYCHIAT, V78, pE264, DOI 10.4088/JCP.16r10832
   Carney CP, 2006, J GEN INTERN MED, V21, P1133, DOI 10.1111/j.1525-1497.2006.00563.x
   Casademont J, 2007, J CLIN PSYCHOPHARM, V27, P284, DOI 10.1097/JCP.0b013e318054753e
   Chintoh AF, 2008, J CLIN PSYCHOPHARM, V28, P494, DOI 10.1097/JCP.0b013e318184b4c5
   Chintoh AF, 2009, SCHIZOPHR RES, V108, P127, DOI 10.1016/j.schres.2008.12.012
   Coccurello R, 2010, PHARMACOL THERAPEUT, V127, P210, DOI 10.1016/j.pharmthera.2010.04.008
   Colli A, 1999, DIABETES CARE, V22, P176, DOI 10.2337/diacare.22.1.176a
   Cooper GD, 2008, PROG NEURO-PSYCHOPH, V32, P428, DOI 10.1016/j.pnpbp.2007.09.012
   Cooper GD, 2007, J PSYCHOPHARMACOL, V21, P405, DOI 10.1177/0269881106069637
   Correll CU, 2004, PSYCHOPHARMACOLOGY, V174, P477, DOI 10.1007/s00213-004-1949-9
   Daniel DG, 1998, PSYCHOPHARMACOL BULL, V34, P61
   De Hert M, 2012, CNS DRUGS, V26, P733, DOI 10.2165/11634500-000000000-00000
   De Hert M, 2011, EUR ARCH PSY CLIN N, V261, P231, DOI 10.1007/s00406-010-0142-x
   Devlin MJ, 2000, AM J PSYCHIAT, V157, P854, DOI 10.1176/appi.ajp.157.6.854
   Doucette DE, 2000, ANN PHARMACOTHER, V34, P1128
   Drzyzga L, 2006, BRAIN BEHAV IMMUN, V20, P532, DOI 10.1016/j.bbi.2006.02.002
   Dwyer DS, 2003, PHARMACOL BIOCHEM BE, V75, P255, DOI 10.1016/S0091-3057(03)00079-0
   Dwyer DS, 1999, PROG NEURO-PSYCHOPH, V23, P69, DOI 10.1016/S0278-5846(98)00092-X
   Dwyer DS, 1999, NEUROSCI LETT, V274, P151, DOI 10.1016/S0304-3940(99)00712-0
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Evans DR, 2003, PROSTAG LEUKOTR ESS, V69, P393, DOI 10.1016/j.plefa.2003.08.010
   Ferno J, 2005, PHARMACOGENOMICS J, V5, P298, DOI 10.1038/sj.tpj.6500323
   Ferno J, 2009, PSYCHOPHARMACOLOGY, V203, P73, DOI 10.1007/s00213-008-1370-x
   Field BCT, 2009, BRIT J CLIN PHARMACO, V68, P830, DOI 10.1111/j.1365-2125.2009.03522.x
   Fuller BE, 2011, GEN HOSP PSYCHIAT, V33, P232, DOI 10.1016/j.genhosppsych.2011.03.006
   Gagliano A, 2004, J CHILD ADOL PSYCHOP, V14, P39, DOI 10.1089/104454604773840472
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Gallhofer B, 2007, PHARMACOPSYCHIATRY, V40, P275, DOI 10.1055/s-2007-990291
   Galling B, 2016, JAMA PSYCHIAT, V73, P247, DOI 10.1001/jamapsychiatry.2015.2923
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Gil-Campos M, 2004, CLIN NUTR, V23, P963, DOI 10.1016/j.clnu.2004.04.010
   Girault JA, 2004, ARCH NEUROL-CHICAGO, V61, P641, DOI 10.1001/archneur.61.5.641
   Goudie AJ, 2002, J PSYCHOPHARMACOL, V16, P291, DOI 10.1177/026988110201600402
   Gupta A, 2014, INDIAN J CLIN BIOCHE, V29, P196, DOI 10.1007/s12291-013-0415-z
   Gury C, 2004, ENCEPHALE, V30, P382
   Haddad PM, 2002, DRUGS, V62, P1649, DOI 10.2165/00003495-200262110-00006
   Hale AS, 1998, INT CLIN PSYCHOPHARM, V13, pS65, DOI 10.1097/00004850-199803003-00011
   Hasnain M, 2010, CURR DIABETES REP, V10, P209, DOI 10.1007/s11892-010-0112-8
   Hassanali Z, 2010, DIABETES OBES METAB, V12, P139, DOI 10.1111/j.1463-1326.2009.01130.x
   Hatziagelaki E, 2019, EXP THER MED, V17, P3071, DOI 10.3892/etm.2019.7285
   Haupt DW, 2001, J CLIN PSYCHIAT, V62, P15
   Hegedus C, 2015, J PSYCHOPHARMACOL, V29, P1271, DOI 10.1177/0269881115602952
   Hemmrich K, 2006, MOL PSYCHIATR, V11, P980, DOI 10.1038/sj.mp.4001892
   Hemmrich K, 2011, J CLIN PSYCHOPHARM, V31, P663, DOI 10.1097/JCP.0b013e31822bf0a5
   Hermann RC, 2002, PSYCHIATR SERV, V53, P425, DOI 10.1176/appi.ps.53.4.425
   Hou JCQ, 2007, CURR OPIN CELL BIOL, V19, P466, DOI 10.1016/j.ceb.2007.04.018
   Houseknecht KL, 2007, NEUROPSYCHOPHARMACOL, V32, P289, DOI 10.1038/sj.npp.1301209
   Hsu JH, 2014, PSYCHOSOMATICS, V55, P163, DOI 10.1016/j.psym.2013.06.001
   Idris N, 2010, PSYCHOPHARMACOLOGY, V208, P23, DOI 10.1007/s00213-009-1702-5
   Jassim G, 2012, PSYCHOPHARMACOLOGY, V219, P783, DOI 10.1007/s00213-011-2397-y
   Ji BH, 2009, J PROTEOME RES, V8, P3633, DOI 10.1021/pr800876z
   Morlán-Coarasa MJ, 2016, PSYCHOPHARMACOLOGY, V233, P3947, DOI 10.1007/s00213-016-4422-7
   Karamatskos E, 2012, EXPERT OPIN DRUG SAF, V11, P1047, DOI 10.1517/14740338.2012.726984
   Kemner C, 2002, J CLIN PSYCHOPHARM, V22, P455, DOI 10.1097/00004714-200210000-00003
   Kerr Thomas A, 2007, Case Rep Gastroenterol, V1, P15, DOI 10.1159/000104222
   Khalil RB, 2012, CLIN NEUROPHARMACOL, V35, P141, DOI 10.1097/WNF.0b013e31824d5288
   Kotzka J, 2004, EXPERT OPIN THER TAR, V8, P141, DOI 10.1517/eott.8.2.141.30248
   Kumra S, 1997, J AM ACAD CHILD PSY, V36, P701, DOI 10.1097/00004583-199705000-00022
   Lauressergues E, 2011, N-S ARCH PHARMACOL, V383, P423, DOI 10.1007/s00210-010-0597-3
   Lauressergues E, 2010, N-S ARCH PHARMACOL, V381, P427, DOI 10.1007/s00210-010-0499-4
   LEADBETTER R, 1992, AM J PSYCHIAT, V149, P68
   Li SS, 2009, JAMA-J AM MED ASSOC, V302, P179, DOI 10.1001/jama.2009.976
   Li YM, 2017, NEUROPSYCH DIS TREAT, V13, P2477, DOI 10.2147/NDT.S145069
   Liu H, 2014, WORLD J GASTROENTERO, V20, P8407, DOI 10.3748/wjg.v20.i26.8407
   Madhusoodanan S, 1999, Ann Clin Psychiatry, V11, P113
   Maric NP, 2016, DRUG DEVELOP RES, V77, P357, DOI 10.1002/ddr.21337
   Martínez JA, 2006, J PHYSIOL BIOCHEM, V62, P303, DOI 10.1007/BF03165759
   Massart Julie, 2017, J Clin Transl Res, V3, P212, DOI 10.18053/jctres.03.2017S1.006
   McDonagh M, 2010, BROKEN MIRRORS-BROKEN MINDS: THE DARK DREAMS OF DARIO ARGENTO, P3
   McEvoy JP, 2005, SCHIZOPHR RES, V80, P19, DOI 10.1016/j.schres.2005.07.014
   McKenney JM, 2007, AM J HEALTH-SYST PH, V64, P595, DOI 10.2146/ajhp060164
   McNamara RK, 2012, PHARMACOL RES, V66, P283, DOI 10.1016/j.phrs.2012.06.010
   Meyer JM, 2002, J CLIN PSYCHIAT, V63, P425, DOI 10.4088/JCP.v63n0509
   Meyer JM, 2004, SCHIZOPHR RES, V70, P1, DOI 10.1016/j.schres.2004.01.014
   Minet-Ringuet J, 2007, MOL PSYCHIATR, V12, P562, DOI 10.1038/sj.mp.4001948
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Monji A, 2009, PSYCHIAT CLIN NEUROS, V63, P257, DOI 10.1111/j.1440-1819.2009.01945.x
   Monteiro Silvia, 2006, Rev Port Cardiol, V25, P821
   Moore N, 2003, PHARMACOEPIDEM DR S, V12, P271, DOI 10.1002/pds.848
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Newcomer JW, 2007, J CLIN PSYCHIAT, V68, P8
   Newcomer JW, 2002, ARCH GEN PSYCHIAT, V59, P337, DOI 10.1001/archpsyc.59.4.337
   Newcomer JW, 2005, CNS DRUGS, V19, P1
   O'Connell KE, 2014, SCHIZOPHR RES, V156, P1, DOI 10.1016/j.schres.2014.03.020
   Olefsky JM, 2010, ANNU REV PHYSIOL, V72, P219, DOI 10.1146/annurev-physiol-021909-135846
   Olfson M, 2006, AM J PSYCHIAT, V163, P1821, DOI 10.1176/appi.ajp.163.10.1821
   Pachikian B. D., 2008, BMC Physiology, V8, P21, DOI 10.1186/1472-6793-8-21
   Pachikian BD, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023365
   Peet M, 2002, J PSYCHIAT RES, V36, P7, DOI 10.1016/S0022-3956(01)00048-6
   Pillai A, 2007, J PSYCHIATR RES, V41, P372, DOI 10.1016/j.jpsychires.2006.01.011
   Polydoro M, 2004, PHARMACOL BIOCHEM BE, V78, P751, DOI 10.1016/j.pbb.2004.05.018
   Pouzet B, 2003, PHARMACOL BIOCHEM BE, V75, P133, DOI 10.1016/S0091-3057(03)00042-X
   Qi KM, 2008, CLIN NUTR, V27, P424, DOI 10.1016/j.clnu.2008.02.001
   Raeder MB, 2006, MOL CELL BIOCHEM, V289, P167, DOI 10.1007/s11010-006-9160-4
   Ranjekar PK, 2003, PSYCHIAT RES, V121, P109, DOI 10.1016/S0165-1781(03)00220-8
   Reddy RD, 2004, SCHIZOPHRENIA BULL, V30, P901, DOI 10.1093/oxfordjournals.schbul.a007140
   Rizos E, 2015, IN VIVO, V29, P529
   Rodefer JS, 2008, NEUROPSYCHOPHARMACOL, V33, P2657, DOI 10.1038/sj.npp.1301654
   Rossor AM, 2007, J CLIN PSYCHOPHARM, V27, P395, DOI 10.1097/01.jcp.0000264988.55603.bb
   Rummel-Kluge C, 2010, SCHIZOPHR RES, V123, P225, DOI 10.1016/j.schres.2010.07.012
   Said MA, 2012, SINGAP MED J, V53, P801
   Sapra M, 2016, SCHIZOPHR RES, V174, P132, DOI 10.1016/j.schres.2016.04.051
   Schaffer LF, 2016, NEUROCHEM RES, V41, P1170, DOI 10.1007/s11064-015-1811-y
   Sertié AL, 2011, PROG NEURO-PSYCHOPH, V35, P1884, DOI 10.1016/j.pnpbp.2011.07.017
   Shimano H, 2001, PROG LIPID RES, V40, P439, DOI 10.1016/S0163-7827(01)00010-8
   Slim M, 2016, DRUG SAFETY, V39, P925, DOI 10.1007/s40264-016-0436-7
   Smith GC, 2008, DIABETOLOGIA, V51, P2309, DOI 10.1007/s00125-008-1152-3
   Smith GC, 2009, SCHIZOPHR RES, V115, P30, DOI 10.1016/j.schres.2009.07.011
   Sobis J, 2015, PHARMACOL REP, V67, P353, DOI 10.1016/j.pharep.2014.09.007
   Sokal J, 2004, J NERV MENT DIS, V192, P421, DOI 10.1097/01.nmd.0000130135.78017.96
   Soliman HM, 2013, FOLIA BIOL-PRAGUE, V59, P173
   Street JS, 2000, ARCH GEN PSYCHIAT, V57, P968, DOI 10.1001/archpsyc.57.10.968
   Tagami K, 2016, NEUROPEPTIDES, V58, P93, DOI 10.1016/j.npep.2015.12.010
   Tarantino G, 2007, HEPATOL RES, V37, P410, DOI 10.1111/j.1872-034X.2007.00072.x
   Targher G, 2010, J HEPATOL, V53, P713, DOI 10.1016/j.jhep.2010.04.030
   Tulipano G, 2007, NEUROENDOCRINOLOGY, V85, P61, DOI 10.1159/000100981
   Turner Trevor, 2007, BMJ, V334 Suppl 1, ps7, DOI 10.1136/bmj.39034.609074.94
   Van Gaal LF, 2006, EUR NEUROPSYCHOPHARM, V16, pS142, DOI 10.1016/j.euroneuro.2006.06.005
   Vanuzzo D, 2010, G ITAL CARDIOL, V11, p25S, DOI 10.1714/576.6811
   Vestri HS, 2007, NEUROPSYCHOPHARMACOL, V32, P765, DOI 10.1038/sj.npp.1301142
   Victoriano M, 2010, BRAIN RES, V1350, P167, DOI 10.1016/j.brainres.2010.05.060
   Victoriano M, 2009, PSYCHOPHARMACOLOGY, V206, P167, DOI 10.1007/s00213-009-1593-5
   Virkkunen M, 2002, PHARMACOPSYCHIATRY, V35, P124, DOI 10.1055/s-2002-31521
   Warnez S, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/1471-244X-14-102
   Weiden PJ, 2003, J CLIN PSYCHOPHARM, V23, P595, DOI 10.1097/01.jcp.0000095347.32154.08
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Wetterling T, 2007, PSYCHIAT PRAX, V34, P223, DOI 10.1055/s-2006-940056
   Wirshing DA, 2002, J CLIN PSYCHIAT, V63, P856, DOI 10.4088/JCP.v63n1002
   Yang LH, 2007, PHARMACOL RES, V56, P202, DOI 10.1016/j.phrs.2007.05.007
   Yang Z, 2009, CLIN CHIM ACTA, V408, P98, DOI 10.1016/j.cca.2009.07.021
   Zhang JP, 2013, INT J NEUROPSYCHOPH, V16, P1205, DOI 10.1017/S1461145712001277
   Zhang Y, 2014, PSYCHOPHARMACOLOGY, V231, P2211, DOI 10.1007/s00213-013-3410-4
   Zimbroff DL, 1997, AM J PSYCHIAT, V154, P782
NR 152
TC 49
Z9 51
U1 1
U2 22
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2019
VL 15
BP 2087
EP 2099
DI 10.2147/NDT.S208061
PG 13
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA IK8PW
UT WOS:000476858100001
PM 31413575
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Parsanathan, R
   Jain, SK
AF Parsanathan, Rajesh
   Jain, Sushil K.
TI Hydrogen sulfide regulates circadian-clock genes in
   C2C12 myotubes and the muscle of high-fat-diet-fed
   mice
SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Article
DE Hydrogen sulfide (H2S); Glutathione (GSH); Oxidative stress (OS); Core
   clock genes (CCG)
ID TUMOR-NECROSIS-FACTOR; OXIDATIVE STRESS; TNF-ALPHA; RESPONSE ELEMENT;
   SKELETAL-MUSCLE; ADIPOSE-TISSUE; HEART-FAILURE; PLASMA-LEVELS;
   TRANSCRIPTION; EXPRESSION
AB Hydrogen sulfide (H2S) is an endogenous novel gasotransmitter which is implicated in the pathophysiology of the metabolic syndrome. Core clock genes (CCG) and its controlled genes disruption is implicated in the progression of metabolic syndrome. We examined whether H2S has any effect on CCG in the skeletal muscle of mice fed a high-fat diet (HFD) and in myotubes. In the muscle of HFD-mice, the expression of H2S biosynthesis enzyme genes (CSE, CBS, and 3-Mpst) along with antioxidant genes (GCLC, GCLM, GSS, and GSR) involved in GSH biosynthesis and recycling were reduced significantly, but the oxidative stress (OS) increased. Expression of the CCG (Bmal1, Clock, ROR alpha, Cry2, Per2) and clock-controlled genes (PPAR gamma, PGC-1 alpha, RXR alpha) was downregulated, whereas the levels of PPAR alpha mRNA were upregulated. Similar to that in the muscle of HFD-mice, in vitro myotubes exposed to high glucose or palmitate to mimic metabolic syndrome, showed an increased OS and decreased in CSE mRNA, H2S production and CCG mRNA levels were also downregulated. TNF and MCP-1 treatment on the myotubes was similar to that observed in HFD-muscle, with that the Rev-erba mRNA was upregulated. Inhibition (siRNA/pharmacological inhibitors) of both CSE and GCLC (the rate-limiting enzyme in GSH biosynthesis) decreased H2S, and increased OS; Bmal1 and Clock mRNA levels were downregulated, while Rev-erba increased significantly in these conditions. CSE KD myotubes were post-treated with an H2S donor partially restored the mRNA levels of core clock genes. These findings report that the deficiencies of H2S/GSH impair expression of CCG and treatment with H2S donor or GSH precursor exert a positive effect over CCG. Thus, suggest that H2S as a new endogenous factor for regulating circadian clock, and its donors could provide a novel chrono-pharmacological therapy to manage metabolic disorders.
C1 Louisiana State Univ, Hlth Sci Ctr Shreveport, Dept Pediat, 1501 Kings Highway, Shreveport, LA 71130 USA.
   Louisiana State Univ, Hlth Sci Ctr Shreveport, Ctr Cardiovasc Dis & Sci, 1501 Kings Highway, Shreveport, LA 71130 USA.
C3 Louisiana State University System; Louisiana State University Health
   Sciences Center at Shreveport; Louisiana State University System;
   Louisiana State University Health Sciences Center at Shreveport
RP Jain, SK (corresponding author), 1501 Kings Highway, Shreveport, LA 71130 USA.
EM sjain@lsuhsc.edu
RI Parsanathan, Rajesh/C-2635-2016
FU Malcolm W. Feist Cardiovascular Research Fellowship; Endowed Chair in
   Diabetes; Center for Cardiovascular Diseases and Sciences (CCDS);
   LSUHSC, Shreveport; National Institutes of Health/National Center for
   Complementary and Integrative Health [RO1 AT007442]
FX This study was supported by a Malcolm W. Feist Cardiovascular Research
   Fellowship to RP and the Endowed Chair in Diabetes to SKJ from the
   Center for Cardiovascular Diseases and Sciences (CCDS), LSUHSC,
   Shreveport, as well as grants to SKJ from the National Institutes of
   Health/National Center for Complementary and Integrative Health (RO1
   AT007442, 2013-16). We thank Ms. Paula Polk, Manager, and Dr. Wiola
   Luszczek, Research Specialist, at the Research Core Facility at
   Louisiana State University Health Sciences Center in Shreveport for
   their expert technical assistance. We also thank Mr. William E. McLean
   for lab assistance. The authors thank Ms. Georgia Morgan for excellent
   editing.
CR Akashi M, 2005, NAT STRUCT MOL BIOL, V12, P441, DOI 10.1038/nsmb925
   Aker S, 2003, AM J PHYSIOL-REG I, V285, pR463, DOI 10.1152/ajpregu.00153.2003
   Anderson EJ, 2006, AM J PHYSIOL-CELL PH, V290, pC844, DOI 10.1152/ajpcell.00402.2005
   Bin P, 2017, BIOMED RES INT, V2017, DOI 10.1155/2017/9584932
   Blackstone E, 2005, SCIENCE, V308, P518, DOI 10.1126/science.1108581
   CANDILOROS H, 1995, DIABETES CARE, V18, P549, DOI 10.2337/diacare.18.4.549
   Chaix A, 2014, CELL METAB, V20, P991, DOI 10.1016/j.cmet.2014.11.001
   Chen LH, 2014, PPAR RES, V2014, DOI 10.1155/2014/653017
   Cho HY, 2010, AM J RESP CRIT CARE, V182, P170, DOI 10.1164/rccm.200907-1047OC
   Corsello T, 2018, ANTIOXIDANTS-BASEL, V7, DOI 10.3390/antiox7100129
   Dugbartey GJ, 2018, ANTIOXID REDOX SIGN, V28, P1503, DOI 10.1089/ars.2017.7127
   Ferreira RC, 2003, MEM I OSWALDO CRUZ, V98, P407, DOI 10.1590/S0074-02762003000300021
   Finck BN, 2005, CELL METAB, V1, P133, DOI 10.1016/j.cmet.2005.01.006
   Green CB, 2008, CELL, V134, P728, DOI 10.1016/j.cell.2008.08.022
   Hatori M, 2012, CELL METAB, V15, P848, DOI 10.1016/j.cmet.2012.04.019
   Hey-Mogensen M, 2010, DIABETOLOGIA, V53, P1976, DOI 10.1007/s00125-010-1813-x
   Hilton TN, 2008, PHYS THER, V88, P1336, DOI 10.2522/ptj.20080079
   Hine C, 2015, CELL, V160, P132, DOI 10.1016/j.cell.2014.11.048
   Huang WY, 2011, J CLIN INVEST, V121, P2133, DOI 10.1172/JCI46043
   Jain SK, 2018, ANTIOXID REDOX SIGN, V29, P1792, DOI 10.1089/ars.2017.7462
   Jain SK, 2012, METAB SYNDR RELAT D, V10, P331, DOI 10.1089/met.2012.0045
   Jialal I, 2012, J CLIN ENDOCR METAB, V97, pE1844, DOI 10.1210/jc.2012-2498
   Jin S, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00682
   Kohsaka A, 2007, CELL METAB, V6, P414, DOI 10.1016/j.cmet.2007.09.006
   Leone V, 2015, CELL HOST MICROBE, V17, P681, DOI 10.1016/j.chom.2015.03.006
   Li YP, 2000, AM J PHYSIOL-REG I, V279, pR1165, DOI 10.1152/ajpregu.2000.279.4.R1165
   Liu C, 2007, NATURE, V447, P477, DOI 10.1038/nature05767
   Manna P, 2017, ARCH BIOCHEM BIOPHYS, V615, P22, DOI 10.1016/j.abb.2017.01.002
   Maury E, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20071597
   Módis K, 2013, BIOCHEM BIOPH RES CO, V433, P401, DOI 10.1016/j.bbrc.2013.02.131
   Okuno Y, 2010, ENDOCR J, V57, P303, DOI 10.1507/endocrj.K09E-113
   Parsanathan R, 2019, ARCH BIOCHEM BIOPHYS, V663, P11, DOI 10.1016/j.abb.2018.12.023
   Parsanathan R, 2019, FREE RADICAL BIO MED, V131, P376, DOI 10.1016/j.freeradbiomed.2018.12.017
   Parsanathan R, 2018, AMINO ACIDS, V50, P909, DOI 10.1007/s00726-018-2559-x
   Parsanathan R, 2018, FREE RADICAL RES, V52, P288, DOI 10.1080/10715762.2018.1431626
   Peng YJ, 2017, P NATL ACAD SCI USA, V114, P1413, DOI 10.1073/pnas.1620717114
   Plomgaard P, 2005, EXERC IMMUNOL REV, V11, P53
   Polvani S, 2012, PPAR RES, V2012, DOI 10.1155/2012/641087
   Preitner N, 2002, CELL, V110, P251, DOI 10.1016/S0092-8674(02)00825-5
   Radhakrishnan Preethi, 2014, Indian J Endocrinol Metab, V18, P505, DOI 10.4103/2230-8210.137498
   Rajesh P, 2014, J ENDOCRINOL, V223, P47, DOI 10.1530/JOE-14-0111
   Serin Y, 2019, ANN NUTR METAB, V74, P322, DOI 10.1159/000500071
   Shang ZX, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-23
   Stein A, 2013, REDOX BIOL, V1, P32, DOI 10.1016/j.redox.2012.11.006
   Ueda HR, 2002, NATURE, V418, P534, DOI 10.1038/nature00906
   Uludag MO, 2016, INT J PHARMACOL, V12, P587, DOI 10.3923/ijp.2016.587.596
   Volpato GP, 2008, ANESTHESIOLOGY, V108, P659, DOI 10.1097/ALN.0b013e318167af0d
   Wilking M, 2013, ANTIOXID REDOX SIGN, V19, P192, DOI 10.1089/ars.2012.4889
   Wu DD, 2015, MED GAS RES, V5, DOI 10.1186/s13618-014-0022-y
   Wyse CA, 2011, MED HYPOTHESES, V77, P1139, DOI 10.1016/j.mehy.2011.09.023
   Xie ZZ, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/6043038
   Yin L, 2006, SCIENCE, V311, P1002, DOI 10.1126/science.1121613
   Young ME, 2014, J BIOL RHYTHM, V29, P257, DOI 10.1177/0748730414543141
   Yuzefovych LV, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054059
   Zhao SP, 1997, INT J CARDIOL, V58, P257, DOI 10.1016/S0167-5273(96)02873-2
NR 55
TC 16
Z9 18
U1 0
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-9861
EI 1096-0384
J9 ARCH BIOCHEM BIOPHYS
JI Arch. Biochem. Biophys.
PD SEP 15
PY 2019
VL 672
AR 108054
DI 10.1016/j.abb.2019.07.019
PG 10
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA LC6JI
UT WOS:000525439000004
PM 31351068
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Saltiel, AR
   Olefsky, JM
AF Saltiel, Alan R.
   Olefsky, Jerrold M.
TI Inflammatory mechanisms linking obesity and metabolic disease
SO JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Review
ID INDUCED INSULIN-RESISTANCE; ENDOPLASMIC-RETICULUM STRESS;
   ADIPOSE-TISSUE; HOMEOSTASIS; MICE
AB There are currently over 1.9 billion people who are obese or overweight, leading to a rise in related health complications, including insulin resistance, type 2 diabetes, cardiovascular disease, liver disease, cancer, and neurodegeneration. The finding that obesity and metabolic disorder are accompanied by chronic low-grade inflammation has fundamentally changed our view of the underlying causes and progression of obesity and metabolic syndrome. We now know that an inflammatory program is activated early in adipose expansion and during chronic obesity, permanently skewing the immune system to a proinflammatory phenotype, and we are beginning to delineate the reciprocal influence of obesity and inflammation. Reviews in this series examine the activation of the innate and adaptive immune system in obesity; inflammation within diabetic islets, brain, liver, gut, and muscle; the role of inflammation in fibrosis and angiogenesis; the factors that contribute to the initiation of inflammation; and therapeutic approaches to modulate inflammation in the context of obesity and metabolic syndrome.
C1 [Saltiel, Alan R.; Olefsky, Jerrold M.] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA.
C3 University of California System; University of California San Diego
EM asaltiel@ucsd.edu; jolefsky@ucsd.edu
RI Saltiel, Alan/L-3632-2019
FU UCSD/UCLA NIDDK Diabetes Research Center [P30 DK063491]
FX The authors acknowledge the support of UCSD/UCLA NIDDK Diabetes Research
   Center P30 DK063491.
CR Amar J, 2011, EMBO MOL MED, V3, P559, DOI 10.1002/emmm.201100159
   Arkan MC, 2005, NAT MED, V11, P191, DOI 10.1038/nm1185
   Blackburn P, 2006, OBESITY, V14, P1747, DOI 10.1038/oby.2006.201
   Chun TH, 2006, CELL, V125, P577, DOI 10.1016/j.cell.2006.02.050
   Crewe C, 2017, J CLIN INVEST, V127, P74, DOI 10.1172/JCI88883
   Eguchi K, 2017, J CLIN INVEST, V127, P14, DOI 10.1172/JCI88877
   Goldfine AB, 2017, J CLIN INVEST, V127, P83, DOI 10.1172/JCI88884
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Holland WL, 2007, CELL METAB, V5, P167, DOI 10.1016/j.cmet.2007.01.002
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Hotamisligil GS, 2010, NAT MED, V16, P396, DOI 10.1038/nm0410-396
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   Jais A, 2017, J CLIN INVEST, V127, P24, DOI 10.1172/JCI88878
   Khan T, 2009, MOL CELL BIOL, V29, P1575, DOI 10.1128/MCB.01300-08
   Koyama Y, 2017, J CLIN INVEST, V127, P55, DOI 10.1172/JCI88881
   Lackey DE, 2016, NAT REV ENDOCRINOL, V12, P15, DOI 10.1038/nrendo.2015.189
   Lanthier N, 2010, AM J PHYSIOL-GASTR L, V298, pG107, DOI 10.1152/ajpgi.00391.2009
   Lee YS, 2014, CELL, V157, P1339, DOI 10.1016/j.cell.2014.05.012
   Lesniewski LA, NAT MED
   Li PP, 2016, CELL, V167, P973, DOI 10.1016/j.cell.2016.10.025
   Li PP, 2015, NAT MED, V21, P239, DOI 10.1038/nm.3800
   Lumeng CN, 2007, J CLIN INVEST, V117, P175, DOI 10.1172/JCI29881
   Lumeng CN, 2011, J CLIN INVEST, V121, P2111, DOI 10.1172/JCI57132
   Mathis D, 2013, CELL METAB, V17, P851, DOI 10.1016/j.cmet.2013.05.008
   McLaughlin T, 2017, J CLIN INVEST, V127, P5, DOI 10.1172/JCI88876
   Nakamura T, 2010, CELL, V140, P338, DOI 10.1016/j.cell.2010.01.001
   Obstfeld AE, 2010, DIABETES, V59, P916, DOI 10.2337/db09-1403
   Oh DY, 2012, CELL METAB, V15, P564, DOI 10.1016/j.cmet.2012.04.009
   Saberi M, 2009, CELL METAB, V10, P419, DOI 10.1016/j.cmet.2009.09.006
   Shi H, 2006, J CLIN INVEST, V116, P3015, DOI 10.1172/JCI28898
   Singer K, 2017, J CLIN INVEST, V127, P65, DOI [10.1172/JCI88882, 10.1172/jci88882]
   Stienstra R, 2011, P NATL ACAD SCI USA, V108, P15324, DOI 10.1073/pnas.1100255108
   Summers SA, 2010, CURR OPIN LIPIDOL, V21, P128, DOI 10.1097/MOL.0b013e3283373b66
   Sun K, 2011, J CLIN INVEST, V121, P2094, DOI 10.1172/JCI45887
   Swinburn BA, 2011, LANCET, V378, P804, DOI 10.1016/S0140-6736(11)60813-1
   Trayhurn P, 2013, PHYSIOL REV, V93, P1, DOI 10.1152/physrev.00017.2012
   Vandanmagsar B, 2011, NAT MED, V17, P179, DOI 10.1038/nm.2279
   Wellen KE, 2007, CELL, V129, P537, DOI 10.1016/j.cell.2007.02.049
   Winer DA, 2017, J CLIN INVEST, V127, P33, DOI 10.1172/JCI88879
   Wu HZ, 2017, J CLIN INVEST, V127, P43, DOI [10.1172/JCI88880, 10.1172/jci88880]
   Zick Yehiel, 2005, Sci STKE, V2005, ppe4, DOI 10.1126/stke.2682005pe4
NR 41
TC 1442
Z9 1567
U1 21
U2 378
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA
SN 0021-9738
EI 1558-8238
J9 J CLIN INVEST
JI J. Clin. Invest.
PD JAN 3
PY 2017
VL 127
IS 1
BP 1
EP 4
DI 10.1172/JCI92035
PG 4
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA EI1UK
UT WOS:000392271300001
PM 28045402
OA Bronze, Green Published, Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Aldea, M
   Tomuleasa, C
   Petrushev, B
   Susman, S
   Kacso, GL
   Irimie, A
   Florian, IS
   Soritau, O
AF Aldea, M.
   Tomuleasa, C.
   Petrushev, B.
   Susman, S.
   Kacso, G. L.
   Irimie, A.
   Florian, I. S.
   Soritau, O.
TI Antidiabetic pharmacology: a link between metabolic syndrome and
   neuro-oncology?
SO JOURNAL OF BUON
LA English
DT Review
DE cancer stem cell metabolism; chemotherapy; glioma; metformin
ID OXIDATIVE STRESS; CANCER; METFORMIN; CELL; MECHANISMS; EXPRESSION;
   STRATEGIES; TUMORS; GLUT3; AMPK
AB One of the main topics of the annual meeting of the American Society for Clinical Oncology in 2011 were the results presented on breast cancer chemotherapy and concomitant administration of the oral antidiabetic metformin. The overall agreement was that current evidence is just enough to dramatically change the clinical practice of oncology, and in our case, brain cancer treatment, and that further research is needed to address the relationship between diabetes, metabolism, insulin analogues and neoplasia. Still, it is very interesting to explore the potentially beneficial effects of metformin in glioma chemo/immunotherapy and wait for results in the clinic.
   In the current paper we present the cell and molecular aspects of the metabolic syndrome, metformin administration and cancer chemotherapy, with a special emphasis in neuro-oncology, since brain tumors are usually devastating diseases with an extremely high mortality within two years of diagnosis even when surgical, radiotherapeutic and chemotherapeutic interventions are applied.
C1 [Aldea, M.; Tomuleasa, C.; Petrushev, B.; Soritau, O.] Ion Chiricuta Oncol Inst, Dept Canc Immunol, Cluj Napoca 400015, Romania.
   [Susman, S.] Ion Chiricuta Oncol Inst, Dept Pathol, Cluj Napoca 400015, Romania.
   [Kacso, G. L.] Ion Chiricuta Oncol Inst, Dept Radiat Oncol, Cluj Napoca 400015, Romania.
   [Irimie, A.] Ion Chiricuta Oncol Inst, Dept Surg, Cluj Napoca 400015, Romania.
   [Florian, I. S.] Iuliu Hatieganu Univ Med, Dept Neurosurg, Cluj Napoca, Romania.
C3 Oncology Institute Prof. Dr. Ion Chiricuta; Oncology Institute Prof. Dr.
   Ion Chiricuta; Oncology Institute Prof. Dr. Ion Chiricuta; Oncology
   Institute Prof. Dr. Ion Chiricuta; Iuliu Hatieganu University of
   Medicine & Pharmacy
RP Tomuleasa, C (corresponding author), Ion Chiricuta Oncol Inst, Dept Canc Immunol, Republicii St 34,36, Cluj Napoca 400015, Romania.
EM ciprian.tomuleasa@gmail.com
RI Petrushev, Bobe/AAA-7810-2019; Tomuleasa, Ciprian/F-3030-2017; Irimie,
   Alexandru/C-7046-2012; Aldea, Mihaela/MDT-8065-2025; Florian, Ioan
   Stefan/D-5934-2016
OI Florian, Ioan Stefan/0000-0001-7127-0946; Aldea,
   Mihaela/0000-0001-7685-051X; Tomuleasa, Ciprian/0000-0001-5500-1519
FU Romanian Ministry of Research and Education [1161]
FX All the experiments on glioma cancer stem cell research were carried out
   at the Laboratory of Cell Cultures, Department of Cancer Immunology, Ion
   Chiricuta Oncology Institute in Cluj Napoca, Romania. The financial
   support was possible through a grant of the Romanian Ministry of
   Research and Education, Project of Exploratory Research, Contract ID
   1161.
CR Albesiano E, 2010, NEUROSURG CLIN N AM, V21, P17, DOI 10.1016/j.nec.2009.08.008
   Amato RJ, 2007, SURG ONCOL CLIN N AM, V16, P975, DOI 10.1016/j.soc.2007.07.006
   Bari D Study Grp, 2009, NEW ENGL J MED, V360, P2503, DOI 10.1056/NEJMoa0805796
   Behin A, 2003, LANCET, V361, P323, DOI 10.1016/S0140-6736(03)12328-8
   Berstein LM, 2010, BREAST CANC IN PRESS
   BOADO RJ, 1994, MOL BRAIN RES, V27, P51, DOI 10.1016/0169-328X(94)90183-X
   Bodmer M, 2010, DIABETES CARE, V33, P1304, DOI 10.2337/dc09-1791
   Brooks GA, 2009, J PHYSIOL-LONDON, V587, P5591, DOI 10.1113/jphysiol.2009.178350
   Chong CR, 2009, ONCOLOGIST, V14, P1178, DOI 10.1634/theoncologist.2009-0286
   Chung SSM, 2003, J AM SOC NEPHROL, V14, pS233, DOI 10.1097/01.ASN.0000077408.15865.06
   Cook JA, 2004, SEMIN RADIAT ONCOL, V14, P259, DOI 10.1016/j.semradonc.2004.04.001
   Corti A, 2010, ARCH BIOCHEM BIOPHYS, V500, P107, DOI 10.1016/j.abb.2010.05.014
   Diamanti-Kandarakis E, 2010, ANN NY ACAD SCI, V1205, P192, DOI 10.1111/j.1749-6632.2010.05679.x
   Emerling BM, 2009, FREE RADICAL BIO MED, V46, P1386, DOI 10.1016/j.freeradbiomed.2009.02.019
   Grisouard J, 2010, BIOCHEM PHARMACOL, V80, P1736, DOI 10.1016/j.bcp.2010.08.021
   Jalving M, 2010, EUR J CANCER, V46, P2369, DOI 10.1016/j.ejca.2010.06.012
   Jansen M, 2009, PHYSIOL REV, V89, P777, DOI 10.1152/physrev.00026.2008
   Jezek P, 2010, INT J BIOCHEM CELL B, V42, P604, DOI 10.1016/j.biocel.2009.11.008
   Jones KL, 2009, LANCET ONCOL, V10, P1179, DOI 10.1016/S1470-2045(09)70315-8
   Jordan CT, 2006, NEW ENGL J MED, V355, P1253, DOI 10.1056/NEJMra061808
   Kaida H, 2010, CLIN NUCL MED, V35, P505, DOI 10.1097/RLU.0b013e3181e05d79
   Linehan WM, 2010, NAT REV UROL, V7, P277, DOI 10.1038/nrurol.2010.47
   Liu BL, 2009, CELL CYCLE, V8, P2031, DOI 10.4161/cc.8.13.8814
   Liu Y, 2009, BRAIN RES, V1304, P149, DOI 10.1016/j.brainres.2009.09.083
   Martin-Castillo B, 2010, ANN ONCOL, V21, P187, DOI 10.1093/annonc/mdp494
   Motzer RJ, 2008, LANCET, V372, P449, DOI 10.1016/S0140-6736(08)61039-9
   Peng TI, 2010, ANN NY ACAD SCI, V1201, P183, DOI 10.1111/j.1749-6632.2010.05634.x
   Ayala FRR, 2010, MOLECULES, V15, P2374, DOI 10.3390/molecules15042374
   Samuel VT, 2010, LANCET, V375, P2267, DOI 10.1016/S0140-6736(10)60408-4
   Stockhammer F, 2008, J MOL HISTOL, V39, P553, DOI 10.1007/s10735-008-9191-0
   Stupp R, 2010, ANN ONCOL, V21, pv190, DOI 10.1093/annonc/mdq187
   Tomuleasa C, 2010, J GASTROINTEST LIVER, V19, P61
   Wen PY, 2008, NEW ENGL J MED, V359, P492, DOI 10.1056/NEJMra0708126
   Zadra G, 2010, CLIN CANCER RES, V16, P3322, DOI 10.1158/1078-0432.CCR-09-1955
NR 34
TC 9
Z9 10
U1 0
U2 9
PU IMPRIMATUR PUBLICATIONS
PI ATHENS
PA 30 DEM POLIORKETES ST, ATHENS, 136 76, GREECE
SN 1107-0625
EI 2241-6293
J9 J BUON
JI J. BUON
PD JUL-SEP
PY 2011
VL 16
IS 3
BP 409
EP 413
PG 5
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 829FL
UT WOS:000295563900003
PM 22006741
DA 2025-06-11
ER

PT J
AU Pérez-Matute, P
   Zulet, MA
   Martínez, JA
AF Perez-Matute, Patricia
   Angeles Zulet, M.
   Alfredo Martinez, J.
TI Reactive species and diabetes: counteracting oxidative stress to improve
   health
SO CURRENT OPINION IN PHARMACOLOGY
LA English
DT Review
ID NADPH OXIDASE; SUPEROXIDE-PRODUCTION; METABOLIC SYNDROME; FREE-RADICALS;
   INSULIN-RESISTANCE; OXYGEN; DISEASE; OBESITY; REDOX; MITOCHONDRIA
AB Oxidative stress is at the very core of metabolism. Reactive species behave as true second messengers that control important cellular functions. However, under pathological conditions, abnormally large concentrations of these species may lead to permanent changes in signal transduction and gene expression. Attenuation of oxidative stress as a way to improve several diseases such as diabetes has flourished as one of the main challenges of research. The lack of evidence to prove the benefits from antioxidant compounds has led to boost these strategies. Inhibition of reactive oxygen species (ROS) production through the development of inhibitors against NADPH oxidase and mitochondria offers an alternative approach to conventional antioxidant therapies. There is a need to understand oxidative stress process to implement health-disorder approaches.
C1 [Perez-Matute, Patricia; Angeles Zulet, M.; Alfredo Martinez, J.] Univ Navarra, Dept Nutr Food Sci Physiol & Toxicol, Pamplona 31008, Spain.
C3 University of Navarra
RP Pérez-Matute, P (corresponding author), Univ Navarra, Dept Nutr Food Sci Physiol & Toxicol, Pamplona 31008, Spain.
EM cpperez@riojasalud.es; mazulet@unav.es; jalfmtz@unav.es
RI MATUTE, CARMEN/AAB-2907-2019; Martinez Hernandez, J Alfredo/K-8709-2014;
   Zulet, M. Angeles/H-1317-2017
OI Martinez Hernandez, J Alfredo/0000-0001-5218-6941; Perez-Matute,
   Patricia/0000-0003-2232-7971; Zulet, M. Angeles/0000-0002-3926-0892
FU Linea Especial about Nutrition, Obesity, and Health [LE/97]; Health
   Department of the Government of Navarra in Spain [22/2007]
FX Investigations about oxidative stress and human health arc being
   supported by the Linea Especial about Nutrition, Obesity, and Health
   (University of Navarra LE/97) and the Health Department of the
   Government of Navarra in Spain (22/2007).
CR Anderson EJ, 2009, J CLIN INVEST, V119, P573, DOI 10.1172/JCI37048
   Andreyev AI, 2005, BIOCHEMISTRY-MOSCOW+, V70, P200, DOI 10.1007/s10541-005-0102-7
   Zulet MA, 2009, NUTR RES, V29, P41, DOI 10.1016/j.nutres.2008.11.003
   Antoniades C, 2009, EUR HEART J, V30, P1142, DOI 10.1093/eurheartj/ehp061
   Babior BM, 2002, ISRAEL MED ASSOC J, V4, P1023
   Babior BM, 2000, IUBMB LIFE, V50, P267, DOI 10.1080/15216540051080976
   Babior BM, 2002, ARCH BIOCHEM BIOPHYS, V397, P342, DOI 10.1006/abbi.2001.2642
   Barbosa KBF, 2008, AN SIST SANIT NAVAR, V31, P259, DOI 10.4321/s1137-66272008000500006
   Bashan N, 2009, PHYSIOL REV, V89, P27, DOI 10.1152/physrev.00014.2008
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Campión J, 2006, J PHYSIOL BIOCHEM, V62, P71, DOI 10.1007/BF03174068
   Crujeiras AB, 2006, NUTRITION, V22, P593, DOI 10.1016/j.nut.2006.03.008
   Dai J, 2008, AM J CLIN NUTR, V88, P1364, DOI 10.3945/ajcn.2008.26528
   Dröge W, 2002, PHYSIOL REV, V82, P47, DOI 10.1152/physrev.00018.2001
   El-Ghoroury EA, 2009, BLOOD COAGUL FIBRIN, V20, P248, DOI 10.1097/MBC.0b013e3283254549
   Forbes JM, 2008, DIABETES, V57, P1446, DOI 10.2337/db08-0057
   Fortuño A, 2004, J HYPERTENS, V22, P2169, DOI 10.1097/00004872-200411000-00020
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gao L, 2009, CARDIOVASC RES, V82, P9, DOI 10.1093/cvr/cvp031
   García-Lafuente A, 2009, INFLAMM RES, V58, P537, DOI 10.1007/s00011-009-0037-3
   Halliwell B, 2004, BRIT J PHARMACOL, V142, P231, DOI 10.1038/sj.bjp.0705776
   Halliwell B, 1996, ANNU REV NUTR, V16, P33, DOI 10.1146/annurev.nu.16.070196.000341
   Hoffman DL, 2007, AM J PHYSIOL-HEART C, V292, pH101, DOI 10.1152/ajpheart.00699.2006
   José GS, 2008, CLIN SCI, V114, P173, DOI 10.1042/CS20070130
   Keijer J, 2008, CURR OPIN LIPIDOL, V19, P4, DOI 10.1097/MOL.0b013e3282f39f95
   KOMHAUSER C, 2008, PRIMARY CARE DIABETE, V2, P81
   Kovacic P, 2005, CURR MED CHEM, V12, P2601, DOI 10.2174/092986705774370646
   Liu Y, 2009, CELL DEATH DIFFER, V16, P847, DOI 10.1038/cdd.2009.14
   Martínez JA, 2006, J PHYSIOL BIOCHEM, V62, P303, DOI 10.1007/BF03165759
   Masella R, 2005, J NUTR BIOCHEM, V16, P577, DOI 10.1016/j.jnutbio.2005.05.013
   Mayne ST, 2003, J NUTR, V133, p933S, DOI 10.1093/jn/133.3.933S
   Hermsdorff HHM, 2009, NUTRITION, V25, P392, DOI 10.1016/j.nut.2008.09.015
   Münzel T, 2002, ARTERIOSCL THROM VAS, V22, P1761, DOI 10.1161/01.ATV.0000034022.11764.EC
   Nishikawa T, 2000, NATURE, V404, P787, DOI 10.1038/35008121
   Paravicini TM, 2008, DIABETES CARE, V31, pS170, DOI 10.2337/dc08-s247
   Parra MD, 2006, NUTR REV, V64, P338, DOI [10.1301/nr.2006.jul.338-347, 10.1111/j.1753-4887.2006.tb00218.x]
   Parra M.ª D., 2004, Nutr. Hosp., V19, P269
   Pastore A, 2003, CLIN CHIM ACTA, V333, P19, DOI 10.1016/S0009-8981(03)00200-6
   PI J, 2009, TOXICOL APP IN PRESS
   Valdecantos MP, 2009, REV INVEST CLIN, V61, P127
   Potenza MA, 2009, CURR MED CHEM, V16, P94, DOI 10.2174/092986709787002853
   Prabhakar NR, 2007, ANTIOXID REDOX SIGN, V9, P1397, DOI 10.1089/ars.2007.1732
   Prieto-Hontoria PL, 2009, J PHYSIOL BIOCHEM, V65, P43, DOI 10.1007/BF03165968
   Puchau B, 2009, EUR J CLIN NUTR, V63, P858, DOI 10.1038/ejcn.2008.48
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Rosenblat M, 2009, BIOFACTORS, V35, P98, DOI 10.1002/biof.16
   Roth E, 2004, CURR OPIN CLIN NUTR, V7, P161, DOI 10.1097/00075197-200403000-00010
   Schaffer SW, 2009, CAN J PHYSIOL PHARM, V87, P91, DOI 10.1139/Y08-110
   Selemidis S, 2008, CLIN EXP PHARMACOL P, V35, P1395, DOI 10.1111/j.1440-1681.2008.05055.x
   Selemidis S, 2008, PHARMACOL THERAPEUT, V120, P254, DOI 10.1016/j.pharmthera.2008.08.005
   Simon MC, 2006, CELL METAB, V3, P150, DOI 10.1016/j.cmet.2006.02.007
   Smith RAJ, 2008, ANN NY ACAD SCI, V1147, P105, DOI 10.1196/annals.1427.003
   Starkov AA, 2008, ANN NY ACAD SCI, V1147, P37, DOI 10.1196/annals.1427.015
   Sun Y, 1996, FREE RADICAL BIO MED, V21, P335, DOI 10.1016/0891-5849(96)00109-8
   Susnow N, 2009, SEMIN CANCER BIOL, V19, P42, DOI 10.1016/j.semcancer.2008.12.002
   Tahara EB, 2009, FREE RADICAL BIO MED, V46, P1283, DOI 10.1016/j.freeradbiomed.2009.02.008
   Turrens JF, 2003, J PHYSIOL-LONDON, V552, P335, DOI 10.1113/jphysiol.2003.049478
   VALDECANTOS M, 2009, OBESITY FACTS S2, V2, P203
   Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
   Venditti P, 2007, INT J BIOCHEM CELL B, V39, P1731, DOI 10.1016/j.biocel.2007.04.019
   Vignais PV, 2002, CELL MOL LIFE SCI, V59, P1428, DOI 10.1007/s00018-002-8520-9
   Wardman P, 2007, FREE RADICAL BIO MED, V43, P995, DOI 10.1016/j.freeradbiomed.2007.06.026
   Waypa GB, 2002, RESP PHYSIOL NEUROBI, V132, P81, DOI 10.1016/S1569-9048(02)00051-4
   Zawia NH, 2009, FREE RADICAL BIO MED, V46, P1241, DOI 10.1016/j.freeradbiomed.2009.02.006
NR 64
TC 106
Z9 124
U1 2
U2 21
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1471-4892
EI 1471-4973
J9 CURR OPIN PHARMACOL
JI Curr. Opin. Pharmacol.
PD DEC
PY 2009
VL 9
IS 6
BP 771
EP 779
DI 10.1016/j.coph.2009.08.005
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 528KX
UT WOS:000272445300015
PM 19766058
DA 2025-06-11
ER

PT J
AU Chen, WX
   Pang, YL
AF Chen, Weixuan
   Pang, Yanli
TI Metabolic Syndrome and PCOS: Pathogenesis and the Role of Metabolites
SO METABOLITES
LA English
DT Article
DE PCOS; metabolic syndrome; metabolites; gut microbiota; clinical
   application
ID POLYCYSTIC-OVARY-SYNDROME; FARNESOID X RECEPTOR; CHAIN AMINO-ACIDS;
   INSULIN-RESISTANCE; GUT MICROBIOTA; DIAGNOSTIC-CRITERIA; HEPATIC
   STEATOSIS; OXIDATIVE STRESS; ADIPOSE-TISSUE; BILE-ACIDS
AB Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases among women of reproductive age and is associated with many metabolic manifestations, such as obesity, insulin resistance (IR) and hyperandrogenism. The underlying pathogenesis of these metabolic symptoms has not yet been fully elucidated. With the application of metabolomics techniques, a variety of metabolite changes have been observed in the serum and follicular fluid (FF) of PCOS patients and animal models. Changes in metabolites result from the daily diet and occur during uncommon physiological routines. However, some of these metabolite changes may provide evidence to explain possible mechanisms and new approaches for prevention and therapy. This article reviews the pathogenesis of PCOS metabolic symptoms and the relationship between metabolites and the pathophysiology of PCOS. Furthermore, the potential clinical application of some specific metabolites will be discussed.
C1 [Chen, Weixuan; Pang, Yanli] Peking Univ Third Hosp, Dept Obstet & Gynecol, Ctr Reprod Med, Beijing 100191, Peoples R China.
   [Chen, Weixuan; Pang, Yanli] Peking Univ Third Hosp, Natl Clin Res Ctr Obstet & Gynecol, Beijing 100191, Peoples R China.
   [Chen, Weixuan; Pang, Yanli] Peking Univ, Minist Educ, Key Lab Assisted Reprod, Beijing 100191, Peoples R China.
   [Chen, Weixuan; Pang, Yanli] Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing 100191, Peoples R China.
   [Chen, Weixuan; Pang, Yanli] Chinese Acad Med Sci, Res Unit Comprehens Diag, Beijing 100191, Peoples R China.
   [Chen, Weixuan; Pang, Yanli] Chinese Acad Med Sci, Res Unit Treatment Oocyte Maturat Arrest, Beijing 100191, Peoples R China.
C3 Peking University; Peking University; Ministry of Education - China;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Chinese Academy of Medical Sciences - Peking Union Medical College
RP Pang, YL (corresponding author), Peking Univ Third Hosp, Dept Obstet & Gynecol, Ctr Reprod Med, Beijing 100191, Peoples R China.; Pang, YL (corresponding author), Peking Univ Third Hosp, Natl Clin Res Ctr Obstet & Gynecol, Beijing 100191, Peoples R China.; Pang, YL (corresponding author), Peking Univ, Minist Educ, Key Lab Assisted Reprod, Beijing 100191, Peoples R China.; Pang, YL (corresponding author), Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing 100191, Peoples R China.; Pang, YL (corresponding author), Chinese Acad Med Sci, Res Unit Comprehens Diag, Beijing 100191, Peoples R China.; Pang, YL (corresponding author), Chinese Acad Med Sci, Res Unit Treatment Oocyte Maturat Arrest, Beijing 100191, Peoples R China.
EM weixuanchen@bjmu.edu.cn; yanlipang@bjmu.edu.cn
OI Chen, Weixuan/0000-0003-1660-1700; Pang, Yanli/0000-0003-1967-2416
FU National Key Research and Development Program of China [2018YFC1003200,
   2018YFC1003900]; National Natural Science Foundation of China [82171627,
   82022028]; CAMS Innovation Fund for Medical Sciences [2019-I2M-5-001];
   Key Clinical Projects of Peking University Third Hospital
   [BYSYZD2019020]
FX This research was funded by National Key Research and Development
   Program of China (grant number: 2018YFC1003900); National Key Research
   and Development Program of China (grant number: 2018YFC1003200);
   National Natural Science Foundation of China (grant number: 82022028);
   National Natural Science Foundation of China (grant number: 82171627);
   CAMS Innovation Fund for Medical Sciences(grant number: 2019-I2M-5-001);
   Key Clinical Projects of Peking University Third Hospital (grant number:
   BYSYZD2019020) from Y.L.P.
CR Abboud M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010111
   Abdalla M, 2020, LIFE SCI, V259, DOI 10.1016/j.lfs.2020.118174
   Al-Bayyari N, 2021, CLIN NUTR, V40, P870, DOI 10.1016/j.clnu.2020.09.024
   Al-Lahham SH, 2010, EUR J CLIN INVEST, V40, P401, DOI 10.1111/j.1365-2362.2010.02278.x
   Alves ED, 2019, J PHOTOCH PHOTOBIO B, V194, P6, DOI 10.1016/j.jphotobiol.2019.03.006
   Apridonidze T, 2005, J CLIN ENDOCR METAB, V90, P1929, DOI 10.1210/jc.2004-1045
   Arany Z, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1048-7
   Barrea L, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102278
   Benelli E, 2016, INT J ENDOCRINOL, V2016, DOI 10.1155/2016/3204083
   Bil E, 2016, J OBSTET GYNAECOL RE, V42, P837, DOI 10.1111/jog.12985
   Bindels LB, 2015, NAT REV GASTRO HEPAT, V12, P303, DOI 10.1038/nrgastro.2015.47
   Brower M, 2013, J CLIN ENDOCR METAB, V98, pE1967, DOI 10.1210/jc.2013-2815
   Cadagan D, 2016, REPROD BIOL, V16, P53, DOI 10.1016/j.repbio.2015.12.006
   Cao HM, 2014, J ENDOCRINOL, V220, pT47, DOI 10.1530/JOE-13-0339
   CARMINA E, 1992, AM J OBSTET GYNECOL, V167, P1807, DOI 10.1016/0002-9378(92)91779-A
   Chaurasia B, 2019, SCIENCE, V365, P386, DOI 10.1126/science.aav3722
   Chen F, 2021, NPJ BIOFILMS MICROBI, V7, DOI 10.1038/s41522-021-00231-6
   Chen MJ, 2016, BEST PRACT RES CL OB, V37, P119, DOI 10.1016/j.bpobgyn.2016.03.003
   Chen SF, 2019, CELL METAB, V30, P1141, DOI 10.1016/j.cmet.2019.08.021
   Chen TL, 2016, SCI REP-UK, V6, DOI 10.1038/srep20594
   Chu WW, 2020, FERTIL STERIL, V113, P1286, DOI 10.1016/j.fertnstert.2020.01.027
   Corbould A, 2007, J ENDOCRINOL, V192, P585, DOI 10.1677/joe.1.07070
   Corrie L, 2021, MED HYPOTHESES, V154, DOI 10.1016/j.mehy.2021.110644
   Cozzolino M, 2020, EUR J NUTR, V59, P2841, DOI 10.1007/s00394-020-02233-0
   Daan NMP, 2014, FERTIL STERIL, V102, DOI 10.1016/j.fertnstert.2014.08.001
   Delzenne NM, 2011, NAT REV ENDOCRINOL, V7, P639, DOI 10.1038/nrendo.2011.126
   Diamanti-Kandarakis E, 2006, TRENDS MOL MED, V12, P324, DOI 10.1016/j.molmed.2006.05.006
   Diamanti-Kandarakis E, 2012, ENDOCR REV, V33, P981, DOI 10.1210/er.2011-1034
   Ding Y, 2018, GENE, V642, P299, DOI 10.1016/j.gene.2017.11.049
   Dong L, 2019, CELL BIOL INT, V43, P553, DOI 10.1002/cbin.11129
   Drucker DJ, 2018, CELL METAB, V27, P740, DOI 10.1016/j.cmet.2018.03.001
   Escobar-Morreale HF, 2007, TRENDS ENDOCRIN MET, V18, P266, DOI 10.1016/j.tem.2007.07.003
   Escobar-Morreale HF, 2018, NAT REV ENDOCRINOL, V14, P270, DOI 10.1038/nrendo.2018.24
   Eyupoglu ND, 2019, CLIN ENDOCRINOL, V91, P810, DOI 10.1111/cen.14101
   Fauser BCJM, 2004, HUM REPROD, V19, P41, DOI 10.1093/humrep/deh098
   Fruzzetti F, 2017, GYNECOL ENDOCRINOL, V33, P39, DOI 10.1080/09513590.2016.1236078
   Gonzalez FJ, 2018, NAT REV ENDOCRINOL, V15, P21, DOI 10.1038/s41574-018-0096-z
   Guarner F, 1998, INT J FOOD MICROBIOL, V39, P237, DOI 10.1016/S0168-1605(97)00136-0
   Gunning MN, 2017, CLIMACTERIC, V20, P222, DOI 10.1080/13697137.2017.1316256
   Guo YJ, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0153196
   Halama A, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00116
   Han Y, 2019, REPROD BIOMED ONLINE, V39, P332, DOI 10.1016/j.rbmo.2019.04.017
   He CL, 2015, NUTRIENTS, V7, P4555, DOI 10.3390/nu7064555
   He FF, 2020, J OVARIAN RES, V13, DOI 10.1186/s13048-020-00670-3
   He FF, 2021, J OVARIAN RES, V14, DOI 10.1186/s13048-021-00799-9
   He YF, 2020, FOOD FUNCT, V11, P5192, DOI [10.1039/c9fo02554e, 10.1039/C9FO02554E]
   Heianza Y, 2019, GUT, V68, P263, DOI 10.1136/gutjnl-2018-316155
   Heimark D, 2014, ENDOCR J, V61, P111, DOI 10.1507/endocrj.EJ13-0423
   Heshmati J, 2019, PROBIOTICS ANTIMICRO, V11, P1236, DOI 10.1007/s12602-018-9493-9
   Huang JY, 2020, BMC ENDOCR DISORD, V20, DOI 10.1186/s12902-019-0486-9
   Jamilian M, 2018, J OVARIAN RES, V11, DOI 10.1186/s13048-018-0457-1
   Jiang YH, 2020, GYNECOL ENDOCRINOL, V36, P508, DOI 10.1080/09513590.2019.1698026
   Johnson EL, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-16274-w
   Jones H, 2012, J CLIN ENDOCR METAB, V97, P3709, DOI 10.1210/jc.2012-1382
   Kalhori Z, 2019, REPROD FERT DEVELOP, V31, P282, DOI [10.1071/RD18131, 10.1071/rd18131]
   Karamali M, 2018, ARCH IRAN MED, V21, P1
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kayser BD, 2019, METABOLOMICS, V15, DOI 10.1007/s11306-019-1596-0
   Kazemi M, 2021, AM J OBSTET GYNECOL, V224, P428, DOI 10.1016/j.ajog.2020.12.019
   Kazemi M, 2021, OBES REV, V22, DOI 10.1111/obr.13255
   Kelley ST, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0146509
   Kimura I, 2020, PHYSIOL REV, V100, P171, DOI 10.1152/physrev.00041.2018
   Kitatani K, 2008, CELL SIGNAL, V20, P1010, DOI 10.1016/j.cellsig.2007.12.006
   Kong B, 2012, HEPATOLOGY, V56, P1034, DOI 10.1002/hep.25740
   Krznaric Z, 2019, CURR OPIN CLIN NUTR, V22, P401, DOI 10.1097/MCO.0000000000000587
   Kusamoto A, 2021, FASEB J, V35, DOI 10.1096/fj.202101051R
   Kuyucu Y, 2018, REPROD BIOL, V18, P53, DOI 10.1016/j.repbio.2018.01.002
   Laganà AS, 2016, INT J ENDOCRINOL, V2016, DOI 10.1155/2016/6306410
   Lee T, 2008, MOL PHARMACOL, V74, P1599, DOI 10.1124/mol.108.049536
   Lefebvre P, 2009, PHYSIOL REV, V89, P147, DOI 10.1152/physrev.00010.2008
   Legro RS, 2001, AM J MED, V111, P607, DOI 10.1016/S0002-9343(01)00948-2
   Lemaitre RN, 2021, JAMA NETW OPEN, V4, DOI 10.1001/jamanetworkopen.2021.22844
   Lerner A, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22010243
   Li J, 2021, J OBSTET GYNAECOL RE, V47, P1145, DOI 10.1111/jog.14650
   Li TH, 2020, J STEROID BIOCHEM, V204, DOI 10.1016/j.jsbmb.2020.105752
   Li YL, 2023, CRIT REV FOOD SCI, V63, P522, DOI 10.1080/10408398.2021.1951155
   Liang Z, 2021, J ENDOCRINOL INVEST, V44, P1727, DOI 10.1007/s40618-020-01481-5
   Lin AW, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112711
   Lin T, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20020409
   Lindheim L, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0168390
   Liu Q, 2020, LIFE SCI, V260, DOI 10.1016/j.lfs.2020.118310
   Liu R, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00324
   Liu X, 2017, CLIN ENDOCRINOL, V87, P767, DOI 10.1111/cen.13454
   Lizneva D, 2016, FERTIL STERIL, V106, P6, DOI 10.1016/j.fertnstert.2016.05.003
   Lujan ME, 2008, J OBSTET GYNAECOL CA, V30, P671, DOI 10.1016/S1701-2163(16)32915-2
   Lumeng CN, 2011, J CLIN INVEST, V121, P2111, DOI 10.1172/JCI57132
   Lynch CJ, 2014, NAT REV ENDOCRINOL, V10, P723, DOI 10.1038/nrendo.2014.171
   Mammadova G, 2021, EUR J CLIN INVEST, V51, DOI 10.1111/eci.13417
   Leo EEM, 2020, NUTRITION, V71, DOI 10.1016/j.nut.2019.110609
   Meng J, 2021, EUR J OBSTET GYN R B, V257, P19, DOI 10.1016/j.ejogrb.2020.11.070
   Merrill AH, 2002, J BIOL CHEM, V277, P25843, DOI 10.1074/jbc.R200009200
   Meyer ML, 2012, HUM REPROD UPDATE, V18, P112, DOI 10.1093/humupd/dmr046
   Milutinovic DV, 2017, EXP CLIN ENDOCR DIAB, V125, P522, DOI 10.1055/s-0043-104531
   Min ZY, 2020, FRONT CELL DEV BIOL, V8, DOI 10.3389/fcell.2020.567028
   Moghetti P, 2013, J CLIN ENDOCR METAB, V98, pE628, DOI 10.1210/jc.2012-3908
   Monastra G, 2018, CURR DRUG DELIV, V15, P1305, DOI 10.2174/1567201815666180509102641
   Monastra G, 2017, GYNECOL ENDOCRINOL, V33, P1, DOI 10.1080/09513590.2016.1247797
   Mu WC, 2018, NUTRIENTS, V10, DOI 10.3390/nu10070918
   Murphy KG, 2006, NATURE, V444, P854, DOI 10.1038/nature05484
   Mykhalchenko K, 2017, EXPERT REV MOL DIAGN, V17, P723, DOI 10.1080/14737159.2017.1340833
   Naseri P, 2017, LASER MED SCI, V32, P1971, DOI 10.1007/s10103-017-2296-5
   Neinast M, 2019, ANNU REV PHYSIOL, V81, P139, DOI 10.1146/annurev-physiol-020518-114455
   Nestler JE, 1998, J CLIN ENDOCR METAB, V83, P2001, DOI 10.1210/jc.83.6.2001
   Newgard CB, 2012, CELL METAB, V15, P606, DOI 10.1016/j.cmet.2012.01.024
   Nicholson JK, 2012, SCIENCE, V336, P1262, DOI 10.1126/science.1223813
   Nordio M, 2019, EUR REV MED PHARMACO, V23, P5512, DOI 10.26355/eurrev_201906_18223
   Ouchi N, 2011, NAT REV IMMUNOL, V11, P85, DOI 10.1038/nri2921
   Özay ÖE, 2017, GYNECOL ENDOCRINOL, V33, P524, DOI 10.1080/09513590.2017.1296127
   Paoli A, 2020, J TRANSL MED, V18, DOI 10.1186/s12967-020-02277-0
   Pathak P, 2018, HEPATOLOGY, V68, P1574, DOI 10.1002/hep.29857
   Paul C, 2016, GYNECOL ENDOCRINOL, V32, P431, DOI 10.3109/09513590.2016.1144741
   Pedersen HK, 2016, NATURE, V535, P376, DOI 10.1038/nature18646
   Peng Y, 2020, BIOL RES, V53, DOI 10.1186/s40659-020-00317-z
   Peng Y, 2020, MOL MED, V26, DOI 10.1186/s10020-020-00198-8
   Petersen MC, 2018, PHYSIOL REV, V98, P2133, DOI 10.1152/physrev.00063.2017
   Pierre A, 2017, J CLIN ENDOCR METAB, V102, P3970, DOI 10.1210/jc.2017-00308
   Powell DJ, 2003, MOL CELL BIOL, V23, P7794, DOI 10.1128/MCB.23.21.7794-7808.2003
   Prawitt J, 2011, DIABETES, V60, P1861, DOI 10.2337/db11-0030
   Qi XY, 2019, NAT MED, V25, P1225, DOI 10.1038/s41591-019-0509-0
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rajska A, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21144853
   Reckelhoff JF, 2019, MAYO CLIN PROC, V94, P536, DOI 10.1016/j.mayocp.2018.11.016
   Rodriguez Paris V, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-19003-5
   Rosenfield RL, 2016, ENDOCR REV, V37, P467, DOI 10.1210/er.2015-1104
   Russell DW, 2009, J LIPID RES, V50, pS120, DOI 10.1194/jlr.R800026-JLR200
   Salamun V, 2018, EUR J ENDOCRINOL, V179, P1, DOI 10.1530/EJE-18-0175
   Salehi R, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-57672-w
   Sangouni AA, 2022, EUR J NUTR, V61, P1199, DOI 10.1007/s00394-021-02659-0
   Schubert KM, 2000, J BIOL CHEM, V275, P13330, DOI 10.1074/jbc.275.18.13330
   Gholizadeh Shamasbi S, 2019, EUR J NUTR, V58, P629, DOI 10.1007/s00394-018-1648-7
   Shan ZL, 2017, AM J CLIN NUTR, V106, P888, DOI 10.3945/ajcn.117.157107
   Shang YJ, 2020, J CLIN ENDOCR METAB, V105, DOI 10.1210/clinem/dgaa425
   Shawish MI, 2021, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD013211.pub2
   Sherman SB, 2018, GUT MICROBES, V9, P400, DOI 10.1080/19490976.2018.1441664
   Shoaei T, 2015, INT J PREVENTIVE MED, V6, DOI 10.4103/2008-7802.153866
   Shukla P, 2020, MITOCHONDRION, V52, P24, DOI 10.1016/j.mito.2020.02.006
   Siomkajlo M, 2019, ADV CLIN EXP MED, V28, P1263, DOI 10.17219/acem/104542
   Smith LP, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007333
   Song JF, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.593058
   Sprung VS, 2013, CLIN ENDOCRINOL, V78, P438, DOI 10.1111/j.1365-2265.2012.04490.x
   Tagliaferri V, 2017, CLIN ENDOCRINOL, V86, P725, DOI 10.1111/cen.13304
   Talbott EO, 2004, J CLIN ENDOCR METAB, V89, P5454, DOI 10.1210/jc.2003-032237
   Tang WHW, 2019, NAT REV CARDIOL, V16, P137, DOI 10.1038/s41569-018-0108-7
   Thursby E, 2017, BIOCHEM J, V474, P1823, DOI 10.1042/BCJ20160510
   Torres PJ, 2018, J CLIN ENDOCR METAB, V103, P1502, DOI 10.1210/jc.2017-02153
   Trabelsi MS, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8629
   Wahlström A, 2016, CELL METAB, V24, P41, DOI 10.1016/j.cmet.2016.05.005
   Wang DJ, 2020, SCI TOTAL ENVIRON, V745, DOI 10.1016/j.scitotenv.2020.141049
   Wang JW, 2019, J FORMOS MED ASSOC, V118, pS23, DOI 10.1016/j.jfma.2018.08.011
   Wang ZN, 2011, NATURE, V472, P57, DOI 10.1038/nature09922
   Wekker V, 2020, HUM REPROD UPDATE, V26, P942, DOI 10.1093/humupd/dmaa029
   Wieërs G, 2020, FRONT CELL INFECT MI, V9, DOI 10.3389/fcimb.2019.00454
   Xie C, 2017, DIABETES, V66, P613, DOI 10.2337/db16-0663
   Xu WL., 2020, MINERVA ENDOCRINOL, DOI 10.23736/S0391-1977.20.03199-5
   Yang PK, 2021, MOL METAB, V49, DOI 10.1016/j.molmet.2021.101189
   Yildiz BO, 2012, HUM REPROD, V27, P3067, DOI 10.1093/humrep/des232
   Yilmaz M, 2005, GYNECOL ENDOCRINOL, V20, P258, DOI 10.1080/09513590400027265
   Zeng X, 2020, DNA CELL BIOL, V39, P1401, DOI 10.1089/dna.2019.5172
   Zhang BJ, 2019, J STEROID BIOCHEM, V189, P171, DOI 10.1016/j.jsbmb.2019.03.005
   Zhang CY, 2020, FASEB J, V34, P9563, DOI 10.1096/fj.202000605RR
   Zhang JC, 2019, MSYSTEMS, V4, DOI 10.1128/mSystems.00017-19
   Zhang JS, 2019, REPROD BIOL ENDOCRIN, V17, DOI 10.1186/s12958-019-0509-4
   Zhang XS, 2019, INT J ENDOCRINOL, V2019, DOI 10.1155/2019/4386401
   Zhao J, 2019, MINERVA MED, V110, P199, DOI 10.23736/S0026-4806.18.05946-3
   Zhao Y, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-153
   Zheng Q, 2017, CELL DEATH DIS, V8, DOI 10.1038/cddis.2017.494
   Zhou JJ, 2021, AGING-US, V13, P12631, DOI 10.18632/aging.202938
   Zhu SQ, 2019, FERTIL STERIL, V111, P168, DOI 10.1016/j.fertnstert.2018.09.013
   Zhu YQ, 2020, APMIS, V128, P353, DOI 10.1111/apm.13038
   Zou J, 2021, CELL MOL GASTROENTER, V12, P983, DOI 10.1016/j.jcmgh.2021.04.014
NR 170
TC 106
Z9 113
U1 8
U2 50
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD DEC
PY 2021
VL 11
IS 12
AR 869
DI 10.3390/metabo11120869
PG 18
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA XW8EP
UT WOS:000735845700001
PM 34940628
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vaidya, D
   Szklo, M
   Cushman, M
   Holvoet, P
   Polak, J
   Bahrami, H
   Jenny, NS
   Ouyang, P
AF Vaidya, D.
   Szklo, M.
   Cushman, M.
   Holvoet, P.
   Polak, J.
   Bahrami, H.
   Jenny, N. S.
   Ouyang, P.
TI Association of endothelial and oxidative stress with metabolic syndrome
   and subclinical atherosclerosis: multi-ethnic study of atherosclerosis
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE metabolic syndrome; biomarkers; coronary artery atherosclerosis; carotid
   arteries
ID ACUTE CORONARY SYNDROMES; INTERCELLULAR-ADHESION MOLECULE-1; CIRCULATING
   OXIDIZED LDL; INSULIN-RESISTANCE; SOLUBLE THROMBOMODULIN;
   CARDIOVASCULAR-DISEASE; HEART-DISEASE; WILLEBRAND,VON FACTOR;
   BODY-COMPOSITION; ARTERY-DISEASE
AB Background/Objectives: A cluster of metabolic abnormalities termed metabolic syndrome (MetS) is associated with vascular endothelial dysfunction and oxidative internal milieu. We examined whether the association of MetS with subclinical atherosclerosis is explained by biomarkers of endothelial damage and oxidative stress. Subjects/Methods: Multi-Ethnic Study of Atherosclerosis (MESA) is a population-based study of 45- to 84-year-old individuals of four US ethnicities without clinical cardiovascular disease. A random sample of 997 MESA participants had data on the following biomarkers: von Willebrand factor, soluble intercellular adhesion molecule-1 (sICAM-1), CD40 ligand (CD40L), soluble thrombomodulin, E-selectin and oxidized LDL (oxLDL). We examined whether the associations of MetS with B-mode ultrasound-defined common and internal carotid intimal-medial thickness (IMT) and coronary artery calcium (CAC) measured using computerized tomography were explained by the biomarkers using multiple regression methods.
   Results: MetS was associated with higher levels of each of the biomarkers (P<0.001, CD40L-suggestive association P=0.004), with greater IMT (P<0.001), and with greater extent of CAC in those in whom CAC was detectable (P=0.01). The association of MetS with measures of subclinical atherosclerosis remained unchanged after adjustment for the biomarkers. After adjusting for MetS, oxLDL was suggestively associated with greater prevalence of detectable CAC (P=0.005) and thicker internal carotid IMT (P=0.002), whereas sICAM-1 was significantly associated with greater prevalence of detectable CAC (P=0.001).
   Conclusions: The association of MetS with subclinical atherosclerosis was independent of its association with biomarkers of endothelial damage and oxidative stress, suggesting that metabolic abnormalities and oxidative endothelial damage may lead to atherosclerotic disease through distinct mechanisms. European Journal of Clinical Nutrition (2011) 65, 818-825; doi: 10.1038/ejcn.2011.47; published online 20 April 2011
C1 [Vaidya, D.; Ouyang, P.] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21287 USA.
   [Szklo, M.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
   [Cushman, M.; Jenny, N. S.] Univ Vermont, Coll Med, Dept Pathol, Burlington, VT 05405 USA.
   [Holvoet, P.] Katholieke Univ Leuven, Dept Cardiovasc Dis, Louvain, Belgium.
   [Polak, J.] Tufts Univ, Sch Med, Dept Radiol, Boston, MA 02111 USA.
   [Bahrami, H.] Yale Univ, Sch Med, Dept Med, New Haven, CT 06510 USA.
C3 Johns Hopkins University; Johns Hopkins University; Johns Hopkins
   Bloomberg School of Public Health; University of Vermont; KU Leuven;
   Tufts University; Yale University
RP Vaidya, D (corresponding author), Johns Hopkins Univ, Sch Med, Dept Med, 1830 E Monument St,8028A, Baltimore, MD 21287 USA.
EM dvaidya1@jhmi.edu
RI HOLVOET, PAUL/T-8434-2017; Vaidya, Dhananjay/AAL-5684-2020; Cushman,
   Mary/K-1157-2019
OI Holvoet, Paul/0000-0001-9201-0772; Vaidya,
   Dhananjay/0000-0002-7164-1601; Szklo, Moyses/0000-0001-9433-6266;
   Cushman, Mary/0000-0002-7871-6143
FU National Heart, Lung and Blood Institute [N01-HC-95159, N01-HC-95169];
   National Center for Research Resources [UL1 RR 025005]; Belgian Federal
   Government [P06/30]; Bijzonder Onderzoeksfonds of the Katholieke
   Universiteit Leuven [OT/06/56]
FX This research was supported by contracts N01-HC-95159 through
   N01-HC-95169 from the National Heart, Lung and Blood Institute. We thank
   the other investigators, the staff and the participants of the MESA
   study for their valuable contributions. A full list of participating
   MESA investigators and institutions can be found at
   http://www.mesa-nhlbi.org. In addition, DV was supported by UL1 RR
   025005 from the National Center for Research Resources, and funding for
   PH was provided by the Interuniversitaire Attractiepolen Programma of
   the Belgian Federal Government (P06/30) and the Bijzonder
   Onderzoeksfonds of the Katholieke Universiteit Leuven (OT/06/56).
CR AGATSTON AS, 1990, J AM COLL CARDIOL, V15, P827, DOI 10.1016/0735-1097(90)90282-T
   Aukrust P, 1999, CIRCULATION, V100, P614, DOI 10.1161/01.CIR.100.6.614
   Bertoni AG, 2007, DIABETES CARE, V30, P2951, DOI 10.2337/dc07-1042
   Blann AD, 2002, ATHEROSCLEROSIS, V165, P389, DOI 10.1016/S0021-9150(02)00184-3
   Carr JJ, 2005, RADIOLOGY, V234, P35, DOI 10.1148/radiol.2341040439
   Constans J, 2006, CLIN CHIM ACTA, V368, P33, DOI 10.1016/j.cca.2005.12.030
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Halcox JPJ, 2009, CIRCULATION, V119, P1005, DOI 10.1161/CIRCULATIONAHA.108.765701
   Hamburg NM, 2008, AM J CARDIOL, V101, P82, DOI 10.1016/j.amjcard.2007.07.053
   Holvoet P, 1998, CIRCULATION, V98, P1487, DOI 10.1161/01.CIR.98.15.1487
   Holvoet P, 2004, DIABETES, V53, P1068, DOI 10.2337/diabetes.53.4.1068
   Holvoet P, 2003, ARTERIOSCL THROM VAS, V23, P1444, DOI 10.1161/01.ATV.0000080379.05071.22
   HOLVOET P, 1994, FASEB J, V8, P1279, DOI 10.1096/fasebj.8.15.8001740
   Holvoet P, 2008, Verh K Acad Geneeskd Belg, V70, P193
   Holvoet P, 2008, JAMA-J AM MED ASSOC, V299, P2287, DOI 10.1001/jama.299.19.2287
   Holvoet P, 2007, ATHEROSCLEROSIS, V194, P245, DOI 10.1016/j.atherosclerosis.2006.08.002
   Jacobs M, 2009, EUR J CLIN INVEST, V39, P437, DOI 10.1111/j.1365-2362.2009.02129.x
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   Lawson C, 2009, PHARMACOL REP, V61, P22, DOI 10.1016/S1734-1140(09)70004-0
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   *NCBI, 2011, SNP DAT, V2009
   OLEARY DH, 1991, STROKE, V22, P1155, DOI 10.1161/01.STR.22.9.1155
   Register TC, 2004, CLIN CHEM, V50, P2185, DOI 10.1373/clinchem.2004.036806
   Sakkinen PA, 2000, AM J EPIDEMIOL, V152, P897, DOI 10.1093/aje/152.10.897
   Schönbeck U, 2001, CIRC RES, V89, P1092, DOI 10.1161/hh2401.101272
   Spiel AO, 2008, CIRCULATION, V117, P1449, DOI 10.1161/CIRCULATIONAHA.107.722827
   Tang Weihong, 2007, BMC Cardiovasc Disord, V7, P30, DOI 10.1186/1471-2261-7-30
   Vaidya Dhananjay, 2007, Metabolic Syndrome and Related Disorders, V5, P343, DOI 10.1089/met.2007.0014
   Wu KK, 2003, CURR OPIN LIPIDOL, V14, P373, DOI 10.1097/01.mol.0000083766.66245.44
   Wu KK, 2003, CIRCULATION, V107, P1729, DOI 10.1161/01.CIR.0000064894.97094.4F
NR 30
TC 36
Z9 37
U1 0
U2 9
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0954-3007
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD JUL
PY 2011
VL 65
IS 7
BP 818
EP 825
DI 10.1038/ejcn.2011.47
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 788OT
UT WOS:000292455000006
PM 21505504
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Gatselis, NK
   Ntaios, G
   Makaritsis, K
   Dalekos, GN
AF Gatselis, Nikolaos K.
   Ntaios, George
   Makaritsis, Konstantinos
   Dalekos, George N.
TI Adiponectin: a key playmaker adipocytokine in non-alcoholic fatty liver
   disease
SO CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Review
DE Non-alcoholic fatty liver disease; Steatosis; Adiponectin;
   Adipocytokines
ID MOLECULAR-WEIGHT ADIPONECTIN; INSULIN-RESISTANCE; SERUM ADIPONECTIN;
   HEPATIC STEATOSIS; PLASMA ADIPONECTIN; TNF-ALPHA;
   HEPATOCELLULAR-CARCINOMA; INDEPENDENT PREDICTOR; METABOLIC SYNDROME;
   OXIDATIVE STRESS
AB Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and can progress to cirrhosis, liver failure, and hepatocellular carcinoma. In the last two decades, the prevalence of NAFLD has been growing in most developed countries, mainly as a consequence of its close association with obesity and diabetes mellitus. The exact pathogenesis of NAFLD and especially the mechanisms leading to disease progression have not been completely understood. Adipocytes produce and secrete several bioactive substances known as adipocytokines which are implicated in the pathogenesis of the disease. Among them, adiponectin is an insulin-sensitizing adipocytokine possessing multiple beneficial effects on obesity-related medical complication. This review focuses on the role of adiponectin in NAFLD pathogenesis and its potential use as a diagnostic tool but also as therapeutic target for NAFLD management.
C1 [Gatselis, Nikolaos K.; Ntaios, George; Makaritsis, Konstantinos; Dalekos, George N.] Thessaly Univ Med Sch, Dept Med, Larisa 41110, Thessaly, Greece.
   [Gatselis, Nikolaos K.; Ntaios, George; Makaritsis, Konstantinos; Dalekos, George N.] Thessaly Univ Med Sch, Res Lab Internal Med, Larisa 41110, Thessaly, Greece.
C3 University of Thessaly; University of Thessaly
RP Dalekos, GN (corresponding author), Thessaly Univ Med Sch, Dept Med, Larisa 41110, Thessaly, Greece.
EM dalekos@med.uth.gr
RI Ntaios, George/AAG-1908-2019
CR Adams LA, 2005, DIABETIC MED, V22, P1129, DOI 10.1111/j.1464-5491.2005.01748.x
   Adinolfi LE, 2001, HEPATOLOGY, V33, P1358, DOI 10.1053/jhep.2001.24432
   Adinolfi LE, 2005, ALIMENT PHARM THER, V22, P52, DOI 10.1111/j.1365-2036.2005.02597.x
   Ahima RS, 2007, GASTROENTEROLOGY, V132, P444, DOI 10.1053/j.gastro.2006.11.048
   Antuna-Puente B, 2008, DIABETES METAB, V34, P2, DOI 10.1016/j.diabet.2007.09.004
   Arita Y, 2002, CIRCULATION, V105, P2893, DOI 10.1161/01.CIR.0000018622.84402.FF
   Ascha MS, 2010, HEPATOLOGY, V51, P1972, DOI 10.1002/hep.23527
   Ayonrinde OT, 2011, HEPATOLOGY, V53, P800, DOI 10.1002/hep.24097
   Belfort R, 2006, NEW ENGL J MED, V355, P2297, DOI 10.1056/NEJMoa060326
   Bellentani S, 2000, ANN INTERN MED, V132, P112, DOI 10.7326/0003-4819-132-2-200001180-00004
   Bertolani Cristiana, 2008, Pathophysiology, V15, P91, DOI 10.1016/j.pathophys.2008.05.001
   Blüher M, 2007, DIABETES CARE, V30, P280, DOI 10.2337/dc06-1362
   Bobbert T, 2005, DIABETES, V54, P2712, DOI 10.2337/diabetes.54.9.2712
   Bondini Silvia, 2007, Clin Liver Dis, V11, P17
   Browning JD, 2004, HEPATOLOGY, V40, P1387, DOI 10.1002/hep.20466
   Browning JD, 2004, J CLIN INVEST, V114, P147, DOI 10.1172/JCI200422422
   Bugianesi E, 2005, AM J GASTROENTEROL, V100, P1082, DOI 10.1111/j.1572-0241.2005.41583.x
   Bugianesi E, 2005, J CLIN ENDOCR METAB, V90, P3498, DOI 10.1210/jc.2004-2240
   Carter-Kent C, 2008, AM J GASTROENTEROL, V103, P1036, DOI 10.1111/j.1572-0241.2007.01709.x
   Cnop M, 2003, DIABETOLOGIA, V46, P459, DOI 10.1007/s00125-003-1074-z
   Corbetta S, 2011, EUR J CLIN INVEST, V41, P898, DOI 10.1111/j.1365-2362.2011.02498.x
   Day CP, 2006, GASTROENTEROLOGY, V130, P207, DOI 10.1053/j.gastro.2005.11.017
   Ding XK, 2005, AM J PATHOL, V166, P1655, DOI 10.1016/S0002-9440(10)62476-5
   Dubuisson O, 2011, ENDOCRINOLOGY, V152, P3648, DOI 10.1210/en.2011-0225
   Ezaki H, 2009, BIOCHEM BIOPH RES CO, V378, P68, DOI 10.1016/j.bbrc.2008.10.176
   Farrell GC, 2006, HEPATOLOGY, V43, pS99, DOI 10.1002/hep.20973
   Fasshauer M, 2002, BIOCHEM BIOPH RES CO, V290, P1084, DOI 10.1006/bbrc.2001.6307
   Fukushima J, 2009, HEPATOL RES, V39, P724, DOI 10.1111/j.1872-034X.2009.00509.x
   GOODMAN ZD, 1995, SEMIN LIVER DIS, V15, P70, DOI 10.1055/s-2007-1007264
   Halberg N, 2009, DIABETES, V58, P1961, DOI 10.2337/db08-1750
   Handy JA, 2011, BIOCHEM J, V440, P385, DOI 10.1042/BJ20102148
   Hemmann S, 2007, J HEPATOL, V46, P955, DOI 10.1016/j.jhep.2007.02.003
   Holland WL, 2011, NAT MED, V17, P55, DOI 10.1038/nm.2277
   Hu XQ, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-25
   Hui JM, 2004, HEPATOLOGY, V40, P46, DOI 10.1002/hep.20280
   Idilman R, 2008, ALIMENT PHARM THER, V28, P200, DOI 10.1111/j.1365-2036.2008.03723.x
   Jarrar MH, 2008, ALIMENT PHARM THER, V27, P412, DOI 10.1111/j.1365-2036.2007.03586.x
   Kadowaki T, 2005, ENDOCR REV, V26, P439, DOI 10.1210/er.2005-0005
   Kamada Y, 2003, GASTROENTEROLOGY, V125, P1796, DOI 10.1053/j.gastro.2003.08.029
   Kamada Y, 2008, J GASTROENTEROL, V43, P811, DOI 10.1007/s00535-008-2213-6
   Kamada Y, 2007, J HEPATOL, V47, P556, DOI 10.1016/j.jhep.2007.03.020
   Kaser S, 2005, J INTERN MED, V258, P274, DOI 10.1111/j.1365-2796.2005.01543.x
   Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2548, DOI 10.1210/jc.2004-0395
   Khan UI, 2012, METABOLISM, DOI [10.1016/j.metabol.2012.02.005, DOI 10.1016/J.METAB0L.2012.02.005]
   Khattab MA, 2012, J GASTROINTEST LIVER, V21, P59
   Kim SM, 2011, METABOLISM, V60, P1294, DOI 10.1016/j.metabol.2011.01.013
   Kobayashi H, 2004, CIRC RES, V94, pE27, DOI 10.1161/01.RES.0000119921.86460.37
   Koehler E, 2012, LIVER INT, V32, P279, DOI 10.1111/j.1478-3231.2011.02637.x
   Krawczyk K, 2009, J PHYSIOL PHARMACOL, V60, P71
   Kumada M, 2004, CIRCULATION, V109, P2046, DOI 10.1161/01.CIR.0000127953.98131.ED
   Kurtz TW, 2005, ACTA DIABETOL, V42, pS9, DOI 10.1007/s00592-005-0176-0
   Lang HF, 2011, NUTR RES, V31, P378, DOI 10.1016/j.nutres.2011.04.004
   Larsson SC, 2007, BRIT J CANCER, V97, P1005, DOI 10.1038/sj.bjc.6603932
   Lemoine M, 2009, LIVER INT, V29, P1431, DOI 10.1111/j.1478-3231.2009.02022.x
   Lira FS, 2012, CYTOKINE, V57, P98, DOI 10.1016/j.cyto.2011.10.001
   Maeda N, 2001, DIABETES, V50, P2094, DOI 10.2337/diabetes.50.9.2094
   Marchesini G, 2003, HEPATOLOGY, V37, P917, DOI 10.1053/jhep.2003.50161
   Masaki T, 2004, HEPATOLOGY, V40, P177, DOI 10.1002/hep.20282
   Matteoni CA, 1999, GASTROENTEROLOGY, V116, P1413, DOI 10.1016/S0016-5085(99)70506-8
   Moschen AR, 2010, GUT, V59, P1259, DOI 10.1136/gut.2010.214577
   Musso G, 2005, HEPATOLOGY, V42, P1175, DOI 10.1002/hep.20896
   Nawrocki AR, 2006, J BIOL CHEM, V281, P2654, DOI 10.1074/jbc.M505311200
   Neumeier M, 2006, WORLD J GASTROENTERO, V12, P5490, DOI 10.3748/wjg.v12.i34.5490
   Ouchi N, 2001, CIRCULATION, V103, P1057, DOI 10.1161/01.CIR.103.8.1057
   Pagano C, 2005, EUR J ENDOCRINOL, V152, P113, DOI 10.1530/eje.1.01821
   Pajvani UB, 2003, J BIOL CHEM, V278, P9073, DOI 10.1074/jbc.M207198200
   Pajvani UB, 2004, J BIOL CHEM, V279, P12152, DOI 10.1074/jbc.M311113200
   Polyzos SA, 2011, METABOLISM, V60, P313, DOI 10.1016/j.metabol.2010.09.003
   Powell EE, 2005, HEPATOLOGY, V42, P5, DOI 10.1002/hep.20750
   Promrat K, 2004, HEPATOLOGY, V39, P188, DOI 10.1002/hep.20012
   Pyper Sean R, 2010, Nucl Recept Signal, V8, pe002, DOI 10.1621/nrs.08002
   Rubio-Guerra Alberto F, 2011, Ther Adv Cardiovasc Dis, V5, P193, DOI 10.1177/1753944711415307
   Sadik NAH, 2012, HUM EXP TOXICOL, V31, P311, DOI 10.1177/0960327111431091
   Salani B, 2006, OBESITY, V14, P1511, DOI 10.1038/oby.2006.174
   Salman TA, 2010, HEPATOL INT, V4, P767, DOI 10.1007/s12072-010-9216-0
   Sanyal Arun J, 2002, Gastroenterology, V123, P1705, DOI 10.1053/gast.2002.36572
   Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929
   Savage DB, 2003, DIABETES, V52, P910, DOI 10.2337/diabetes.52.4.910
   Sebastiani G, 2006, WORLD J GASTROENTERO, V12, P3682, DOI 10.3748/wjg.v12.i23.3682
   Shimada M, 2007, AM J GASTROENTEROL, V102, P1931, DOI 10.1111/j.1572-0241.2007.01322.x
   Sumie S, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026840
   Summer SS, 2011, OBESITY, V19, P2198, DOI 10.1038/oby.2011.60
   Swarbrick MM, 2006, DIABETOLOGIA, V49, P2552, DOI 10.1007/s00125-006-0452-8
   Tacke F, 2005, J HEPATOL, V42, P666, DOI 10.1016/j.jhep.2004.12.024
   Takagi H, 2012, INT J CARDIOL, V155, P448, DOI 10.1016/j.ijcard.2011.11.071
   Targher G, 2008, OBESITY, V16, P1394, DOI 10.1038/oby.2008.64
   Targher G, 2006, CLIN ENDOCRINOL, V64, P679, DOI 10.1111/j.1365-2265.2006.02527.x
   Tietge UJF, 2004, AM J PHYSIOL-ENDOC M, V287, pE82, DOI 10.1152/ajpendo.00494.2003
   Tilg H, 2000, NEW ENGL J MED, V343, P1467, DOI 10.1056/NEJM200011163432007
   Tomita K, 2006, GUT, V55, P415, DOI 10.1136/gut.2005.071118
   Tomita K, 2008, HEPATOLOGY, V48, P458, DOI 10.1002/hep.22365
   Trujillo ME, 2005, J INTERN MED, V257, P167, DOI 10.1111/j.1365-2796.2004.01426.x
   Tsao TS, 2002, J BIOL CHEM, V277, P29359, DOI 10.1074/jbc.C200312200
   Tsatsanis C, 2005, BIOCHEM BIOPH RES CO, V335, P1254, DOI 10.1016/j.bbrc.2005.07.197
   Turer AT, 2012, J CLIN ENDOCR METAB, V97, pE982, DOI 10.1210/jc.2011-3305
   Videla LA, 2004, FREE RADICAL BIO MED, V37, P1499, DOI 10.1016/j.freeradbiomed.2004.06.033
   VINCENT MF, 1991, DIABETES, V40, P1259, DOI 10.2337/diabetes.40.10.1259
   Waki H, 2003, J BIOL CHEM, V278, P40352, DOI 10.1074/jbc.M300365200
   Wang Y, 2008, BIOCHEM J, V409, P623, DOI 10.1042/BJ20071492
   Wanninger J, 2011, EXP MOL PATHOL, V91, P603, DOI 10.1016/j.yexmp.2011.07.001
   Wanninger J, 2011, FEBS LETT, V585, P1338, DOI 10.1016/j.febslet.2011.04.003
   Wolf AM, 2004, BIOCHEM BIOPH RES CO, V323, P630, DOI 10.1016/j.bbrc.2004.08.145
   Wong VWS, 2006, CLIN GASTROENTEROL H, V4, P1154, DOI 10.1016/j.cgh.2006.06.011
   Wong VWS, 2010, GUT, V59, P969, DOI 10.1136/gut.2009.205088
   Wulster-Radcliffe MC, 2004, BIOCHEM BIOPH RES CO, V316, P924, DOI 10.1016/j.bbrc.2004.02.130
   Xu AM, 2009, ENDOCRINOLOGY, V150, P625, DOI 10.1210/en.2008-0999
   Xu AM, 2003, J CLIN INVEST, V112, P91, DOI 10.1172/JCI200317797
   Xue ZH, 2007, CLIN EXP PHARMACOL P, V34, P27, DOI 10.1111/j.1440-1681.2007.04547.x
   Yamagishi SI, 2007, CURR MOL MED, V7, P463
   Yamauchi T, 2003, NATURE, V423, P762, DOI 10.1038/nature01705
   Yamauchi T, 2002, NAT MED, V8, P1288, DOI 10.1038/nm788
   Yamauchi T, 2001, NAT MED, V7, P941, DOI 10.1038/90984
   Yamauchi T, 2007, NAT MED, V13, P332, DOI 10.1038/nm1557
   Yki-Jarvinen H, 2004, NEW ENGL J MED, V351, P1106, DOI 10.1056/NEJMra041001
   Yokota T, 2003, J IMMUNOL, V171, P5091, DOI 10.4049/jimmunol.171.10.5091
   Yokota T, 2000, BLOOD, V96, P1723, DOI 10.1182/blood.V96.5.1723
   Yokoyama H, 2004, J HEPATOL, V41, P19, DOI 10.1016/j.jhep.2004.03.003
   Younossi ZM, 2008, OBES SURG, V18, P1430, DOI 10.1007/s11695-008-9506-y
   Zelber-Sagi S, 2012, EUR J GASTROEN HEPAT, V24, P262, DOI 10.1097/MEG.0b013e32834f15dd
   Ziemke F, 2010, AM J CLIN NUTR, V91, p258S, DOI 10.3945/ajcn.2009.28449C
   Zografos TA, 2006, J HEPATOL, V44, P848, DOI 10.1016/j.jhep.2006.01.025
   Zografos TA, 2008, AM J GASTROENTEROL, V103, P605, DOI 10.1111/j.1572-0241.2007.01729.x
NR 122
TC 49
Z9 53
U1 1
U2 16
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1591-8890
EI 1591-9528
J9 CLIN EXP MED
JI Clin. Exper. Med.
PD MAY
PY 2014
VL 14
IS 2
BP 121
EP 131
DI 10.1007/s10238-012-0227-0
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AG1CP
UT WOS:000335152900002
PM 23292294
DA 2025-06-11
ER

PT J
AU Belcastro, V
   D'Egidio, C
   Striano, P
   Verrotti, A
AF Belcastro, Vincenzo
   D'Egidio, Claudia
   Striano, Pasquale
   Verrotti, Alberto
TI Metabolic and endocrine effects of valproic acid chronic treatment
SO EPILEPSY RESEARCH
LA English
DT Review
DE Valproic acid; Epileptic syndromes; Metabolic syndrome; Atherosclerosis
ID INTIMA-MEDIA THICKNESS; VASCULAR RISK-FACTORS; FATTY LIVER-DISEASE;
   ANTIEPILEPTIC DRUGS; WEIGHT-GAIN; EPILEPTIC PATIENTS; SODIUM VALPROATE;
   SERUM-INSULIN; HOMOCYSTEINE METABOLISM; CARDIOVASCULAR RISK
AB Treatment of epileptic patients with valproic acid (VPA) may be associated with substantial weight changes that may increase morbidity and impair adherence to the treatment regimen. VPA-induced weight gain seems to be associated with many metabolic disturbances; the most frequent are hyperinsulinemia and insulin resistance, hyperleptinemia and leptin resistance. Patients who gain weight during VPA therapy can develop dyslipidemia and metabolic syndrome that are associated with long-term vascular complications such as hypertension and atherosclerosis. Moreover, an elevation in the levels of uric acid and homocysteine, together with oxidative stress, may contribute to atherosclerotic risk in patients under long-term therapy with VPA.
   The aim of this review is to discuss the metabolic and endocrine effects of VPA chronic treatment in patients with epilepsy. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Belcastro, Vincenzo] St Anna Hosp, Neurol Unit, Dept Neurosci, Como, Italy.
   [D'Egidio, Claudia] Univ G dAnnunzio, Dept Pediat, Chieti, Italy.
   [Striano, Pasquale] Univ Genoa, G Gaslini Inst, Pediat Neurol & Muscular Dis Unit, Dept Neurosci Rehabil Ophtalmol Genet Maternal &, Genoa, Italy.
   [Verrotti, Alberto] Univ Perugia, Dept Pediat, I-06100 Perugia, Italy.
C3 University of Ferrara; Arcispedale Sant'Anna; G d'Annunzio University of
   Chieti-Pescara; University of Genoa; IRCCS Istituto Giannina Gaslini;
   University of Perugia
RP Belcastro, V (corresponding author), St Anna Hosp, Neurol Unit, Dept Neurosci, Como, Italy.
EM vincenzobelcastro@libero.it
RI Spalice, Alberto/AFI-5798-2022; Belcastro, Vincenzo/IAM-0167-2023;
   Striano, Pasquale/F-9117-2014
OI Belcastro, Vincenzo/0000-0002-3416-2900; , Alberto/0000-0002-3670-6115
CR Abaci A, 2009, PEDIATR NEUROL, V41, P435, DOI 10.1016/j.pediatrneurol.2009.06.003
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Aldenkamp A, 2006, ACTA NEUROL SCAND, V114, P1, DOI 10.1111/j.1600-0404.2006.00666.x
   Angulo P, 2002, NEW ENGL J MED, V346, P1221, DOI 10.1038/nrdp.2015.80
   ANNEGERS JF, 1984, EPILEPSIA, V25, P699, DOI 10.1111/j.1528-1157.1984.tb03480.x
   [Anonymous], 1882, American Chemical Journal
   ARNER P, 1995, ANN MED, V27, P435, DOI 10.3109/07853899709002451
   Attilakos A, 2006, EPILEPSY RES, V71, P229, DOI 10.1016/j.eplepsyres.2006.06.015
   Aydin K, 2005, J CHILD NEUROL, V20, P848, DOI 10.1177/08830738050200101501
   Belcastro V, 2007, EPILEPSIA, V48, P1990, DOI 10.1111/j.1528-1167.2007.01164.x
   Belcastro V, 2012, EPILEPSY RES, V102, P1, DOI 10.1016/j.eplepsyres.2012.07.003
   Belcastro V, 2010, EPILEPSIA, V51, P274, DOI 10.1111/j.1528-1167.2009.02303.x
   Berenson GS, 1998, NEW ENGL J MED, V338, P1650, DOI 10.1056/NEJM199806043382302
   Biton V, 2003, J CHILD NEUROL, V18, P133, DOI 10.1177/08830738030180021701
   BREUM L, 1992, METABOLISM, V41, P666, DOI 10.1016/0026-0495(92)90061-E
   Brodie MJ, 2013, EPILEPSIA, V54, P11, DOI 10.1111/j.1528-1167.2012.03671.x
   Brown R, 2008, POLYM TEST, V27, P1, DOI 10.1016/j.polymertesting.2007.12.004
   Chuang YC, 2012, EPILEPSIA, V53, P120, DOI 10.1111/j.1528-1167.2011.03316.x
   de Almeida KM, 2012, CNS NEUROSCI THER, V18, P160, DOI 10.1111/j.1755-5949.2011.00240.x
   de Vries L, 2007, EPILEPSIA, V48, P470, DOI 10.1111/j.1528-1167.2006.00953.x
   Demir E, 2000, PEDIATR NEUROL, V22, P361, DOI 10.1016/S0887-8994(00)00133-8
   Demircioglu S, 2000, PEDIATR NEUROL, V23, P142, DOI 10.1016/S0887-8994(00)00175-2
   EIRIS JM, 1995, NEUROLOGY, V45, P1155, DOI 10.1212/WNL.45.6.1155
   El-Khatib F, 2007, SEIZURE-EUR J EPILEP, V16, P226, DOI 10.1016/j.seizure.2006.12.009
   El-Khayat H, 2004, EPILEPSIA, V45, P1106, DOI 10.1111/j.0013-9580.2004.66303.x
   Elliotta JO, 2007, EPILEPSY RES, V76, P113, DOI 10.1016/j.eplepsyres.2007.07.005
   Erdemir A, 2009, BRAIN DEV-JPN, V31, P713, DOI 10.1016/j.braindev.2008.11.001
   Evans JL, 2003, DIABETES, V52, P1, DOI 10.2337/diabetes.52.1.1
   Fang JJ, 2012, SEIZURE-EUR J EPILEP, V21, P578, DOI 10.1016/j.seizure.2012.06.001
   Fu JF, 2007, INT J OBESITY, V31, P15, DOI 10.1038/sj.ijo.0803453
   Gaitatzis A, 2004, EPILEPSIA, V45, P1613, DOI 10.1111/j.0013-9580.2004.17504.x
   Geda G, 2002, ACTA NEUROL BELG, V102, P122
   Greco R, 2005, NEUROLOGY, V65, P1808, DOI 10.1212/01.wnl.0000187074.27586.d1
   Grosso S, 2009, ANN PHARMACOTHER, V43, P45, DOI 10.1345/aph.1L414
   Gungor S, 2007, J CHILD NEUROL, V22, P1384, DOI 10.1177/0883073807307096
   Hamed SA, 2005, J PHARMACOL SCI, V98, P340, DOI 10.1254/jphs.CRJ05003X
   Hamed SA, 2007, EPILEPSY RES, V74, P183, DOI 10.1016/j.eplepsyres.2007.03.010
   Hamed SA, 2009, EUR J PAEDIATR NEURO, V13, P261, DOI 10.1016/j.ejpn.2008.05.005
   Hassan A, 2004, BRAIN, V127, P212, DOI 10.1093/brain/awh023
   Isojarvi JIT, 1996, ANN NEUROL, V39, P579, DOI 10.1002/ana.410390506
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Kanemura H, 2012, SEIZURE-EUR J EPILEP, V21, P496, DOI 10.1016/j.seizure.2012.05.001
   Karabiber H, 2003, BRAIN DEV-JPN, V25, P113, DOI 10.1016/S0387-7604(02)00163-8
   KASTE M, 1983, STROKE, V14, P525, DOI 10.1161/01.STR.14.4.525
   Kullo IJ, 2005, MAYO CLIN PROC, V80, P219, DOI 10.4065/80.2.219
   Lakhanpal D, 2007, CELL MOL NEUROBIOL, V27, P1069, DOI 10.1007/s10571-007-9201-x
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Landmark CJ, 2008, CNS DRUGS, V22, P27
   Lewis GF, 1996, DIABETES CARE, V19, P390, DOI 10.2337/diacare.19.4.390
   Lihn AS, 2005, OBES REV, V6, P13, DOI 10.1111/j.1467-789X.2005.00159.x
   LoPinto-Khoury C, 2010, CURR TREAT OPTION NE, V12, P300, DOI 10.1007/s11940-010-0080-y
   Luef G, 2002, METABOLISM, V51, P1274, DOI 10.1053/meta.2002.34708
   Luef G, 2009, EPILEPSY RES, V86, P42, DOI 10.1016/j.eplepsyres.2009.04.004
   Luef G, 2002, EPILEPSY RES, V48, P91, DOI 10.1016/S0920-1211(01)00317-5
   Luef GJ, 2004, ANN NEUROL, V55, P729, DOI 10.1002/ana.20074
   Marchesini G, 2001, DIABETES, V50, P1844, DOI 10.2337/diabetes.50.8.1844
   Mattson MP, 2003, TRENDS NEUROSCI, V26, P137, DOI 10.1016/S0166-2236(03)00032-8
   McGarry JD, 2002, DIABETES, V51, P7, DOI 10.2337/diabetes.51.1.7
   MEUNIER H, 1963, Therapie, V18, P435
   Mikkonen K, 2005, EPILEPSIA, V46, P1114, DOI 10.1111/j.1528-1167.2005.34304.x
   Mintzer S, 2009, EPILEPSIA, V50, P42, DOI 10.1111/j.1528-1167.2009.02235.x
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Münzberg H, 2005, NAT NEUROSCI, V8, P566, DOI 10.1038/nn1454
   MUURONEN A, 1985, BRIT MED J, V291, P1481, DOI 10.1136/bmj.291.6507.1481
   Ness-Abramof R, 2005, DRUG TODAY, V41, P547, DOI 10.1358/dot.2005.41.8.893630
   Nikolaos T, 2004, MED SCI MONITOR, V10, pMT50
   Novak GP, 1999, J CHILD NEUROL, V14, P490, DOI 10.1177/088307389901400802
   Olesen JB, 2011, PHARMACOEPIDEM DR S, V20, P146, DOI 10.1002/pds.2073
   PATSCH JR, 1992, ARTERIOSCLER THROMB, V12, P1336, DOI 10.1161/01.ATV.12.11.1336
   Polak JF, 2011, NEW ENGL J MED, V365, P213, DOI 10.1056/NEJMoa1012592
   Prabhakar S, 2007, EPILEPSIA, V48, P1371, DOI 10.1111/j.1528-1167.2007.01100.x
   Privitera MD, 2003, ACTA NEUROL SCAND, V107, P165, DOI 10.1034/j.1600-0404.2003.00093.x
   Prodam F., 2012, J ENDOCRINOL INVEST
   Pylvänen V, 2003, NEUROLOGY, V60, P571, DOI 10.1212/01.WNL.0000048209.07526.86
   Pylvänen V, 2002, EPILEPSIA, V43, P514, DOI 10.1046/j.1528-1157.2002.31501.x
   Pylvänen V, 2006, EPILEPSY BEHAV, V8, P643, DOI 10.1016/j.yebeh.2006.02.008
   Qiao LP, 2006, ENDOCRINOLOGY, V147, P865, DOI 10.1210/en.2005-1030
   Rättyä J, 1999, PEDIATRICS, V103, P588, DOI 10.1542/peds.103.3.588
   Rauchenzauner M, 2008, EPILEPSY RES, V80, P142, DOI 10.1016/j.eplepsyres.2008.03.017
   Rauchenzauner M, 2013, EPILEPSY RES, V104, P285, DOI 10.1016/j.eplepsyres.2012.10.004
   Rauchenzauner M, 2008, EPILEPSIA, V49, P353, DOI 10.1111/j.1528-1167.2007.01460.x
   Rauchenzauner M, 2008, SEIZURE-EUR J EPILEP, V17, P723, DOI 10.1016/j.seizure.2008.03.002
   Sharpe C, 2009, J CHILD NEUROL, V24, P338, DOI 10.1177/0883073808323023
   Sonmez FM, 2006, J CHILD NEUROL, V21, P70, DOI 10.2310/7010.2006.00015
   Stephen LJ, 2001, EPILEPSIA, V42, P1002, DOI 10.1046/j.1528-1157.2001.0420081002.x
   STIEMER B, 1989, HISTOL HISTOPATHOL, V4, P421
   Stocker R, 2004, PHYSIOL REV, V84, P1381, DOI 10.1152/physrev.00047.2003
   Striano P, 2013, EXPERT OPIN PHARMACO, V14, P1355, DOI 10.1517/14656566.2013.800045
   Striano P, 2012, EXPERT REV NEUROTHER, V12, P1411, DOI [10.1586/ERN.12.90, 10.1586/ern.12.90]
   Strong J P, 2001, Nutr Metab Cardiovasc Dis, V11 Suppl 5, P16
   Tan TY, 2009, EPILEPSIA, V50, P1579, DOI 10.1111/j.1528-1167.2009.02024.x
   Temple ME, 2000, ANN PHARMACOTHER, V34, P57, DOI 10.1345/aph.18457
   Tomoum HY, 2008, J CHILD NEUROL, V23, P1275, DOI 10.1177/0883073808318538
   van der Lely AJ, 2004, ENDOCR REV, V25, P426, DOI 10.1210/er.2002-0029
   Verrotti A, 2004, NEUROENDOCRINOLOGY, V79, P157, DOI 10.1159/000077274
   Verrotti A, 2002, J CHILD NEUROL, V17, P265, DOI 10.1177/088307380201700405
   Verrotti A, 1999, NEUROLOGY, V53, P230, DOI 10.1212/WNL.53.1.230
   Verrotti A, 2000, EPILEPSY RES, V41, P253, DOI 10.1016/S0920-1211(00)00150-9
   Verrotti A, 2010, EPILEPSIA, V51, P268, DOI 10.1111/j.1528-1167.2009.02206.x
   Voudris KA, 2006, EPILEPSY RES, V70, P211, DOI 10.1016/j.eplepsyres.2006.05.002
   Wang BY, 2010, J AM GERIATR SOC, V58, P2027, DOI 10.1111/j.1532-5415.2010.03078.x
   Yis U, 2012, BRAIN DEV-JPN, V34, P185, DOI 10.1016/j.braindev.2011.05.009
NR 102
TC 108
Z9 113
U1 0
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0920-1211
EI 1872-6844
J9 EPILEPSY RES
JI Epilepsy Res.
PD NOV
PY 2013
VL 107
IS 1-2
BP 1
EP 8
DI 10.1016/j.eplepsyres.2013.08.016
PG 8
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 273HB
UT WOS:000328524800001
PM 24076030
DA 2025-06-11
ER

PT J
AU Schilder, RJ
   Marden, JH
AF Schilder, Rudolf J.
   Marden, James H.
TI Metabolic syndrome and obesity in an insect
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE chronic inflammation; insect disease model obesity lipid metabolism;
   parasite effects
ID INSULIN-RESISTANCE; SKELETAL-MUSCLE; ADIPOSE-TISSUE; IMMUNE-SYSTEM;
   POWER OUTPUT; P38 MAPK; INFLAMMATION; EXPRESSION; GUT; FAT
AB Dragonflies infected with noninvasive gregarine gut parasites (Microsporidia, Apicomplexa) have reduced flight-muscle performance, an inability to metabolize lipid in their muscles, twofold-elevated hemolymph carbohydrate concentrations, and they accumulate fat in their thorax in a manner analogous to mammalian obesity. Gregarine infection is associated with inappropriate responses of hemolymph carbohydrate concentration to insulin and with chronic activation in the flight muscles of p38 MAP kinase, a signaling molecule involved in immune and stress responses. Short-term exposure to gregarine excretory/secretory products caused elevated blood carbohydrate and p38 MAPK activation in healthy individuals. These characteristics comprise a set of symptoms and processes that are known in mammals as metabolic syndrome but which have not previously been described in other animal taxa. In addition to expanding the known taxonomic breadth of metabolic disease, these results indicate that insects may be useful experimental models for studying its underlying biology and mechanisms.
C1 Penn State Univ, Dept Biol, Mueller Lab 208, University Pk, PA 16802 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Pennsylvania State University -
   University Park; Penn State Behrend
RP Schilder, RJ (corresponding author), Penn State Univ, Dept Biol, Mueller Lab 208, University Pk, PA 16802 USA.
EM rschilder2@uninotes.unl.edu
RI /M-7215-2019
CR Bäckhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Bardet PL, 2006, TRENDS ENDOCRIN MET, V17, P166, DOI 10.1016/j.tem.2006.03.005
   Baron AD, 2001, AM J CARDIOL, V88, p16H, DOI 10.1016/S0002-9149(01)01832-X
   BEENAKKERS A., 1981, Energy Metabolism in Insects
   Beutler B, 2004, MOL IMMUNOL, V40, P845, DOI 10.1016/j.molimm.2003.10.005
   Boucher J, 2005, HORM METAB RES, V37, P761, DOI 10.1055/s-2005-921098
   Carpentier YA, 2006, AM J CLIN NUTR, V83, p1499S, DOI 10.1093/ajcn/83.6.1499S
   Cunningham-Rundles S, 1998, NUTRITION, V14, P573, DOI 10.1016/S0899-9007(98)00029-X
   Dirgahayu P, 2002, INT J PARASITOL, V32, P1155, DOI 10.1016/S0020-7519(02)00090-5
   Esposito K, 2004, NUTR METAB CARDIOVAS, V14, P228, DOI 10.1016/S0939-4753(04)80048-6
   Fantuzzi G, 2005, J ALLERGY CLIN IMMUN, V115, P911, DOI 10.1016/j.jaci.2005.02.023
   Goodpaster BH, 2004, PEDIATR DIABETES, V5, P219, DOI 10.1111/j.1399-543X.2004.00071.x
   Hegele RA, 2005, AM J PHYSIOL-REG I, V289, pR663, DOI 10.1152/ajpregu.00275.2005
   Janeway CA, 2002, ANNU REV IMMUNOL, V20, P197, DOI 10.1146/annurev.immunol.20.083001.084359
   Jiang ZH, 2005, OBES RES, V13, P1898, DOI 10.1038/oby.2005.233
   KALLAPUR VL, 1975, INDIAN J EXP BIOL, V13, P200
   Kelley DE, 2001, DIABETES CARE, V24, P933, DOI 10.2337/diacare.24.5.933
   Kelley DE, 2002, DIABETES, V51, P2944, DOI 10.2337/diabetes.51.10.2944
   Khovidhunkit W, 2004, J LIPID RES, V45, P1169, DOI 10.1194/jlr.R300019-JLR200
   Lammi N, 2005, MED SCI MONITOR, V11, pRA63
   LEWIS SF, 1989, EXERCISE SPORT SCI R, V17, P67
   Li ZP, 2003, HEPATOLOGY, V37, P343, DOI 10.1053/jhep.2003.50048
   Marden JH, 2001, J EXP BIOL, V204, P3457
   Marden JH, 2004, ANIM BEHAV, V68, P857, DOI 10.1016/j.anbehav.2003.09.019
   MARDEN JH, 1994, ANIM BEHAV, V48, P1023, DOI 10.1006/anbe.1994.1335
   Marette A, 2003, INT J OBESITY, V27, pS46, DOI 10.1038/sj.ijo.0802500
   Martinelli C, 2005, J ENDOTOXIN RES, V11, P243, DOI 10.1179/09680510SX37411
   Molavi B, 2006, CURR OPIN CARDIOL, V21, P479, DOI 10.1097/01.hco.0000240586.76344.f5
   Perseghin G, 2005, CURR OPIN LIPIDOL, V16, P416, DOI 10.1097/01.mol.0000174401.07056.56
   Pickup JC, 1998, DIABETOLOGIA, V41, P1241, DOI 10.1007/s001250051058
   Pollex RL, 2006, NAT CLIN PRACT CARD, V3, P482, DOI 10.1038/ncpcardio0638
   Ritov VB, 2005, DIABETES, V54, P8, DOI 10.2337/diabetes.54.1.8
   Roche HM, 2005, P NUTR SOC, V64, P371, DOI 10.1079/PNS2005445
   Ruden DM, 2005, ANNU REV NUTR, V25, P499, DOI 10.1146/annurev.nutr.25.050304.092708
   Satake S, 1997, COMP BIOCHEM PHYS B, V118, P349, DOI 10.1016/S0305-0491(97)00166-1
   SCHMIDTNIELSENK, 1991, ANIMAL PHYSL
   Sharpstone D, 2000, HIV Med, V1, P102, DOI 10.1046/j.1468-1293.2000.00011.x
   Shen YH, 2006, J BIOL CHEM, V281, P7727, DOI 10.1074/jbc.M511105200
   SINGH B, 1993, AUTOIMMUNITY, V15, P209, DOI 10.3109/08916939309019929
   Smith AJ, 2003, COMP PARASITOL, V70, P196, DOI 10.1654/4109
   Teitelbaum JE, 2002, ANNU REV NUTR, V22, P107, DOI 10.1146/annurev.nutr.22.110901.145412
   Tlaskalová-Hogenová H, 2004, IMMUNOL LETT, V93, P97, DOI 10.1016/j.imlet.2004.02.005
   Valerio A, 2006, J CLIN INVEST, V116, P2791, DOI [10.1172/JCI28570, 10.1172/JCI28570.]
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Wisse BE, 2004, J AM SOC NEPHROL, V15, P2792, DOI 10.1097/01.ASN.0000141966.69934.21
   Wyatt G.R., 1967, ADV INSECT PHYSIOL, V4, P287, DOI DOI 10.1016/S0065-2806(08)60210-6
NR 46
TC 57
Z9 68
U1 0
U2 25
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD DEC 5
PY 2006
VL 103
IS 49
BP 18805
EP 18809
DI 10.1073/pnas.0603156103
PG 5
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 114TZ
UT WOS:000242689800075
PM 17132732
OA Green Published
DA 2025-06-11
ER

PT J
AU Ferreira, MD
   Scalzo, MD
   Rodriguez, S
   D'Alessandro, ME
AF Ferreira, Maria del Rosario
   Scalzo, Maria de los Milagros
   Rodriguez, Silvia
   D'Alessandro, Maria Eugenia
TI Changes in cerebral cortex redox status and cognitive performance in
   short-and long-term high-sucrose diet fed rats
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Cerebral cortex; Oxidative stress; Cognition; High-sucrose diet;
   Metabolic syndrome; Rats
ID ADIPOSE-TISSUE DYSFUNCTION; INSULIN-RESISTANT RATS; METABOLIC SYNDROME;
   OXIDATIVE STRESS; RICH DIET; INFLAMMATORY CYTOKINES; SKELETAL-MUSCLE;
   BRAIN; GLUTATHIONE; PATHOPHYSIOLOGY
AB Rising evidence suggests that Metabolic Syndrome (MetS) would be correlated with the development of neurodegenerative diseases. Although this has emerged as a relevant area of research, it has not been fully explored. It is not clear if a greater impairment of the metabolic peripheral environment is accompanied by a greater impairment of the central nervous system. We have previously shown that feeding rats with a highsucrose diet (HSD) represents an animal model that resembles the human MetS phenotype. The aim of the present work was to assess in rats fed a HSD for a short (3 weeks-wk) or a long (15 weeks-wk) term, whether the worsening of the peripheral metabolic and hormonal profile that occur as the time of HSD consumption increases, is also accompanied by a worsening of oxidative stress in the cerebral cortex and/or cognitive behavior. Male Wistar rats received a HSD or a control diet during 3 wk or 15 wk. We found an increase in reactive oxygen species (ROS), thiobarbituric acid reactive substances (TBARS), advanced glycation end products (AGEs) and glutathione peroxidase (GPx) and glutathione reductase (GR) enzyme activities in the cerebral cortex of 3 wk HSD-fed rats. All of these parameters, except for the GPx, were also increased in the 15 wk HSD-fed group and values were similar to those observed at 3 wk. Glutathione reduced form (GSH), catalase (CAT) activity and brain-to-body weight ratio were reduced in 15 wk HSD-fed animals. Glutathione S- transferase (GST) was similar in all dietary groups. A poor performance in novel object recognition test and T-maze memory tasks was observed in 3 wk and 15 wk HSD-fed rats in a similar magnitude. Our results add new evidence related to the association between an adverse peripheral metabolic environment and brain/cognitive dysfunction.
C1 [Ferreira, Maria del Rosario; Scalzo, Maria de los Milagros; D'Alessandro, Maria Eugenia] Univ Nacl Litoral, Fac Bioquim & Ciencias Biol, Lab Estudio Enfermedades Metab Relacionadas Nutr, Ciudad Univ, Santa Fe, Argentina.
   [Ferreira, Maria del Rosario; Rodriguez, Silvia; D'Alessandro, Maria Eugenia] Consejo Nacl Invest Cient & Tecn CONICET, Buenos Aires, Argentina.
C3 National University of the Littoral; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET)
RP Ferreira, MD (corresponding author), Univ Nacl Litoral, Fac Bioquim & Ciencias Biol, cc242,Ciudad Univ, RA-3000 Santa Fe, Argentina.
EM mrferreira@fbcb.unl.edu.ar
OI D' Alessandro, Maria Eugenia/0000-0001-6008-5614; Ferreira, Maria del
   Rosario/0000-0003-0760-9495
FU Agencia Nacional de Promocion de la Investigacion, el Desarrollo
   Tecnologico y la Innovacion- FONCyT, Argentina [PICT-2021-I-INVI-00200];
   Universidad Nacional del Litoral, Argentina [50620190100008LI]
FX This work was supported by Agencia Nacional de Promocion de la
   Investigacion, el Desarrollo Tecnologico y la Innovacion- FONCyT,
   Argentina [grant PICT-2021-I-INVI-00200] and Universidad Nacional del
   Litoral, Argentina [grant CAI + D #50620190100008LI] .
CR Aebi H, 1974, METHODS ENZYM ANAL, V2nd, P673, DOI [10.1016/B978-0-12-091302-2.50032-3, DOI 10.1016/B978-0-12-091302-2.50032-3]
   Aiassa V, 2022, FOOD RES INT, V156, DOI 10.1016/j.foodres.2022.111164
   Albers DS, 2000, J NEURAL TRANSM-SUPP, P133
   Aragno M, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040385
   Arnold SE, 2014, NEUROBIOL DIS, V67, P79, DOI 10.1016/j.nbd.2014.03.011
   Aydin S, 2014, NUTRITION, V30, P1, DOI 10.1016/j.nut.2013.05.013
   Batista AG, 2020, J FUNCT FOODS, V65, DOI 10.1016/j.jff.2019.103745
   Budson A.E., 2016, Memory loss, Alzheimer's disease, and dementia, V2nd
   Celikbilek A, 2014, ACTA NEUROPSYCHIATR, V26, P51, DOI 10.1017/neu.2013.32
   Cepas V, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9020142
   Chicco A, 2003, J NUTR, V133, P127, DOI 10.1093/jn/133.1.127
   Chrysanthou M, 2022, NUTRIENTS, V14, DOI 10.3390/nu14020363
   Cobley JN, 2018, REDOX BIOL, V15, P490, DOI 10.1016/j.redox.2018.01.008
   Creus A, 2016, J CLIN MED, V5, DOI 10.3390/jcm5020018
   D'Alessandro ME, 2006, NUTR RES, V26, P289, DOI 10.1016/j.nutres.2006.06.001
   D'Alessandro ME, 2000, J NUTR BIOCHEM, V11, P273, DOI 10.1016/S0955-2863(00)00078-4
   d'Isa R, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-00402-7
   Deacon RMJ, 2006, NAT PROTOC, V1, P7, DOI 10.1038/nprot.2006.2
   Degrave V., 2023, J. Food Nutr. Metab., P2674, DOI [10.31487/j.JFNM.2023.01.01, DOI 10.31487/J.JFNM.2023.01.01]
   Ferreira MD, 2020, J FUNCT FOODS, V66, DOI 10.1016/j.jff.2019.103775
   Ferreira MD, 2010, ISLETS, V2, P367, DOI 10.4161/isl.2.6.13869
   Denninger JK, 2018, JOVE-J VIS EXP, DOI 10.3791/58593
   ELLMAN GL, 1959, ARCH BIOCHEM BIOPHYS, V82, P70, DOI 10.1016/0003-9861(59)90090-6
   D'Alessandro ME, 2015, FOOD FUNCT, V6, P1299, DOI [10.1039/c4fo00903g, 10.1039/C4FO00903G]
   Fadó R, 2022, NUTRIENTS, V14, DOI 10.3390/nu14194137
   Feigin VL, 2020, LANCET NEUROL, V19, P255, DOI 10.1016/S1474-4422(19)30411-9
   Ferreira MR, 2018, EUR J NUTR, V57, P83, DOI 10.1007/s00394-016-1299-5
   Ferreira MR, 2013, PROSTAG LEUKOTR ESS, V89, P31, DOI 10.1016/j.plefa.2013.04.006
   Frisardi V, 2010, AGEING RES REV, V9, P399, DOI 10.1016/j.arr.2010.04.007
   Garcia Y, 2018, BEHAV SCI, V8, DOI 10.3390/bs8010014
   GLOWINSKI J, 1966, J NEUROCHEM, V13, P655, DOI 10.1111/j.1471-4159.1966.tb09873.x
   HABIG WH, 1974, J BIOL CHEM, V249, P7130
   Hein GJ, 2010, AM J PHYSIOL-ENDOC M, V298, pE429, DOI 10.1152/ajpendo.00513.2009
   Horn H.D., 1965, Glutathione reductase. Methods of Enzymatic Analysis, P875
   Jawabri K H., 2023, Physiology, Cerebral Cortex Functions
   Juan CA, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22094642
   Jurdak N, 2009, PHYSIOL BEHAV, V96, P1, DOI 10.1016/j.physbeh.2008.07.023
   Kalousová M, 2002, PHYSIOL RES, V51, P597, DOI 10.33549/physiolres.930234
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kouvari M, 2022, NUTRIENTS, V14, DOI 10.3390/nu14020333
   LEE HS, 1987, LIPIDS, V22, P104, DOI 10.1007/BF02534861
   Maciejczyk M, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20040874
   Maciejczyk M, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/6940515
   Madani Z, 2015, BIOMED REP, V3, P731, DOI 10.3892/br.2015.498
   Martemucci G, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12122091
   Masenga SK, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24097898
   Massaad CA, 2011, ANTIOXID REDOX SIGN, V14, P2013, DOI 10.1089/ars.2010.3208
   Neergaard JS, 2017, DIABETES, V66, P1957, DOI 10.2337/db16-1444
   Noubiap JJ, 2022, DIABETES RES CLIN PR, V188, DOI 10.1016/j.diabres.2022.109924
   Nowotny K, 2015, BIOMOLECULES, V5, P194, DOI 10.3390/biom5010194
   Oliva ME, 2021, FOOD RES INT, V139, DOI 10.1016/j.foodres.2020.109842
   Oppelt SA, 2017, BRAIN RES, V1657, P312, DOI 10.1016/j.brainres.2016.12.022
   PAGLIA DE, 1967, J LAB CLIN MED, V70, P158
   Patten AR, 2013, J NUTR BIOCHEM, V24, P760, DOI 10.1016/j.jnutbio.2012.04.003
   Peters R, 2006, POSTGRAD MED J, V82, P84, DOI 10.1136/pgmj.2005.036665
   REEVES PG, 1993, J NUTR, V123, P1939, DOI 10.1093/jn/123.11.1939
   Roberts CK, 2013, COMPR PHYSIOL, V3, P1, DOI 10.1002/cphy.c110062
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Rossi AS, 2013, BRIT J NUTR, V109, P1617, DOI 10.1017/S0007114512003558
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Samarghandian S, 2017, BIOMED PHARMACOTHER, V87, P223, DOI 10.1016/j.biopha.2016.12.105
   Sarfert KS, 2019, NUTR NEUROSCI, V22, P344, DOI 10.1080/1028415X.2017.1388557
   Seelke AMH, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0032322
   Serra JA, 2009, NEUROCHEM RES, V34, P2122, DOI 10.1007/s11064-009-9997-5
   Sugita N, 1917, J COMP NEUROL, V28, P495, DOI 10.1002/cne.900280303
   Syeda T, 2022, NUTRIENTS, V14, DOI 10.3390/nu14010022
   TAKEUCHI N, 1976, EXP GERONTOL, V11, P179, DOI 10.1016/0531-5565(76)90031-0
   Joubert MBV, 2022, FOOD FUNCT, V13, P7333, DOI 10.1039/d2fo00642a
   Wahlsten D, 2001, PHYSIOL BEHAV, V73, P695, DOI 10.1016/S0031-9384(01)00527-3
   Wong SK, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0123-9
   World Health Organization, 2019, Risk reduction of cognitive decline and dementia: WHO guidelines
   Yates KF, 2012, ARTERIOSCL THROM VAS, V32, P2060, DOI 10.1161/ATVBAHA.112.252759
   Zebrowska E, 2020, NUTRIENTS, V12, DOI 10.3390/nu12103181
   Zhu YG, 2006, BRAIN RES, V1090, P35, DOI 10.1016/j.brainres.2006.03.063
NR 74
TC 1
Z9 1
U1 1
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
EI 1873-507X
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD MAR 1
PY 2025
VL 290
AR 114776
DI 10.1016/j.physbeh.2024.114776
EA DEC 2024
PG 11
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA P0T1P
UT WOS:001375133700001
PM 39638221
DA 2025-06-11
ER

PT J
AU Andrade, JL
   Hong, YR
   Lee, AM
   Miller, DR
   Williams, C
   Thompson, LA
   Bright, MA
   Cardel, MI
AF Andrade, Joanne L.
   Hong, Young-Rock
   Lee, Alexandra M.
   Miller, Darci R.
   Williams, Charlette
   Thompson, Lindsay A.
   Bright, Melissa A.
   Cardel, Michelle, I
TI Adverse Childhood Experiences Are Associated with Cardiometabolic Risk
   among Hispanic American Adolescents
SO JOURNAL OF PEDIATRICS
LA English
DT Article
ID BLOOD-PRESSURE; ARTERIAL STIFFNESS; VIOLENCE EXPOSURE; HEART-DISEASE;
   SOCIAL-STATUS; OBESITY; STRESS; TRAUMA; HEALTH; ABUSE
AB Objective To assess the relationship between adverse childhood experiences (ACEs) and cardiometabolic risk among Hispanic adolescents.
   Study design This cross-sectional study was conducted at an academic research center in Gainesville, Florida. Participants were locally recruited, and data were collected from June 2016 to July 2018. Participants (n = 133, 60.2% female) were healthy adolescents aged 15-21 years who self-identified as Hispanic, were born in the US, and had a body mass index (BMI) between >= 18.5 and 40 pound kg/m(2). Primary outcomeswere BMI, body fat percentage, waist circumference, and resting blood pressure. Associations between ACEs and cardiometabolic measures were assessed by multivariable logistic regression models, which controlled for sex, age, parental education, and food insecurity. Results were sex-stratified to assess potential variations.
   Results Reporting (3)4 ACEs (28.6%) was significantly associated with a greater BMI (P =.004), body fat percentage (P = .02), and diastolic blood pressure (P =.05) compared with reporting <4 ACEs. Female participants reporting >= 4 ACEs were significantly more likely to have a greater BMI (P = .04) and body fat percentage (P = .03) whereas male participants reporting >= 4 ACEs were significantly more likely to have a greater BMI (P =.04), systolic blood pressure (P = .03), and diastolic blood pressure (P = .03).
   Conclusions Hispanic adolescent participants who experienced >= 4 ACEs were more likely to have elevated risk markers of obesity and cardiometabolic disease. Further research is needed to elucidate the physiological mechanisms driving these relationships.
C1 [Andrade, Joanne L.; Lee, Alexandra M.; Miller, Darci R.; Williams, Charlette; Thompson, Lindsay A.; Cardel, Michelle, I] Univ Florida, Dept Hlth Outcomes & Biomed Informat, Gainesville, FL USA.
   [Hong, Young-Rock] Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Hlth Serv Res Management & Policy, Gainesville, FL USA.
   [Thompson, Lindsay A.; Cardel, Michelle, I] Univ Florida, Dept Pediat, Gainesville, FL USA.
   [Bright, Melissa A.] Univ Florida, Coll Med, Dept Obstet & Gynecol, Gainesville, FL 32610 USA.
   [Cardel, Michelle, I] Univ Florida, Ctr Integrat Cardiovasc & Metab Dis, Gainesville, FL USA.
   [Cardel, Michelle, I] WW Int Inc, New York, NY USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida; State University
   System of Florida; University of Florida; State University System of
   Florida; University of Florida; State University System of Florida;
   University of Florida
RP Cardel, MI (corresponding author), 2004 Mowry Rd,Suite 2247, Gainesville, FL 32610 USA.
EM mcardel@ufl.edu
RI Lee, Alexandra/HTN-7539-2023; Hong, Young-Rock/AAK-8856-2020
OI Hong, Young-Rock/0000-0002-0366-5687; Williams,
   Charlette/0000-0002-8055-1210
CR Adler NE, 2000, HEALTH PSYCHOL, V19, P586, DOI 10.1037/0278-6133.19.6.586
   Alastalo H, 2013, J HUM HYPERTENS, V27, P90, DOI 10.1038/jhh.2012.6
   Anderson DE, 2007, J STRENGTH COND RES, V21, P169, DOI 10.1519/00124278-200702000-00030
   Baldwin JR, 2021, JAMA PEDIATR, V175, P385, DOI 10.1001/jamapediatrics.2020.5602
   Barr DA, 2020, J AM HEART ASSOC, V9, DOI 10.1161/JAHA.120.016162
   Barr DA, 2017, MAYO CLIN PROC, V92, P1415, DOI 10.1016/j.mayocp.2017.06.013
   Bellis MA, 2015, J PUBLIC HEALTH-UK, V37, P445, DOI 10.1093/pubmed/fdu065
   Bethell CD, 2017, ACAD PEDIATR, V17, pS51, DOI 10.1016/j.acap.2017.04.161
   Burke NJ, 2011, CHILD ABUSE NEGLECT, V35, P408, DOI 10.1016/j.chiabu.2011.02.006
   Cardel MI, 2020, OBESITY, V28, P2010, DOI 10.1002/oby.23002
   Centers for Disease Control and Prevention (CDC), 2010, MMWR Morb Mortal Wkly Rep, V59, P1609
   Cheung EL, 2017, PEDIATRICS, V139, DOI 10.1542/peds.2016-1433
   Clark R, 2006, PSYCHOSOM MED, V68, P73, DOI 10.1097/01.psy.0000195744.13608.11
   Cohen JA, 2008, ARCH PEDIAT ADOL MED, V162, P447, DOI 10.1001/archpedi.162.5.447
   Cohen JA, 2015, CHILD ADOL PSYCH CL, V24, P557, DOI 10.1016/j.chc.2015.02.005
   Dempster KS, 2021, BRAIN BEHAV IMMUN, V93, P254, DOI 10.1016/j.bbi.2020.12.018
   Dong MX, 2004, CIRCULATION, V110, P1761, DOI 10.1161/01.CIR.0000143074.54995.7F
   Caballero AE, 2013, CURR CARDIOVASC RISK, V7, P433, DOI 10.1007/s12170-013-0361-6
   Felitti VJ, 1998, AM J PREV MED, V14, P245, DOI 10.1016/S0749-3797(98)00017-8
   Finkelhor D, 2021, JAMA NETW OPEN, V4, DOI 10.1001/jamanetworkopen.2021.1435
   Finkelhor D, 2018, CHILD ABUSE NEGLECT, V85, P174, DOI 10.1016/j.chiabu.2017.07.016
   Finkelhor D, 2013, JAMA PEDIATR, V167, P70, DOI 10.1001/jamapediatrics.2013.420
   Godoy LC, 2021, JAMA CARDIOL, V6, P228, DOI 10.1001/jamacardio.2020.6050
   Hager ER, 2010, PEDIATRICS, V126, pE26, DOI 10.1542/peds.2009-3146
   Hales Craig M, 2017, NCHS Data Brief, P1
   Hansen TW, 2006, CIRCULATION, V113, P664, DOI 10.1161/CIRCULATIONAHA.105.579342
   Heerman WJ, 2016, OBESITY, V24, P696, DOI 10.1002/oby.21413
   Hughes K, 2017, LANCET PUBLIC HEALTH, V2, pE356, DOI 10.1016/S2468-2667(17)30118-4
   Isasi CR, 2016, J PEDIATR-US, V176, P121, DOI 10.1016/j.jpeds.2016.05.037
   Isohookana R, 2016, COMPR PSYCHIAT, V71, P17, DOI 10.1016/j.comppsych.2016.08.002
   Jackson DB, 2019, AM J PREV MED, V57, P667, DOI 10.1016/j.amepre.2019.06.004
   Jensen TK, 2014, J CLIN CHILD ADOLESC, V43, P356, DOI 10.1080/15374416.2013.822307
   Kaplan RC, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.114.000923
   Klassen SA, 2016, CHILD ABUSE NEGLECT, V56, P1, DOI 10.1016/j.chiabu.2016.04.002
   Korkeila J, 2010, HEART, V96, P298, DOI 10.1136/hrt.2009.188250
   Lee SY, 2008, CURR OPIN CLIN NUTR, V11, P566, DOI 10.1097/MCO.0b013e32830b5f23
   Llabre MM, 2017, PSYCHOSOM MED, V79, P172, DOI 10.1097/PSY.0000000000000394
   Merrick MT, 2018, JAMA PEDIATR, V172, P1038, DOI 10.1001/jamapediatrics.2018.2537
   Murali R, 2005, ANN BEHAV MED, V30, P155, DOI 10.1207/s15324796abm3002_8
   Nettle D, 2017, BEHAV BRAIN SCI, V40, DOI [10.1017/S0140525X16002041, 10.1017/S0140525X16000947]
   Noll JG, 2007, PEDIATRICS, V120, pE61, DOI 10.1542/peds.2006-3058
   Noreen EE, 2006, MED SCI SPORT EXER, V38, P1505, DOI 10.1249/01.mss.0000228950.60097.01
   Shin SH, 2012, CHILD ABUSE NEGLECT, V36, P84, DOI 10.1016/j.chiabu.2011.08.007
   Slopen N, 2012, BRAIN BEHAV IMMUN, V26, P239, DOI 10.1016/j.bbi.2011.11.003
   Su SY, 2015, CIRCULATION, V131, P1674, DOI 10.1161/CIRCULATIONAHA.114.013104
   Suglia SF, 2018, CIRCULATION, V137, pE15, DOI 10.1161/CIR.0000000000000536
   Suglia SF, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-1149
   Wells NM, 2010, AM J PUBLIC HEALTH, V100, P2507, DOI 10.2105/AJPH.2009.184291
   WHO, 2011, WORLD REPORT ON DISABILITY, P1
   Williamson DF, 2002, INT J OBESITY, V26, P1075, DOI 10.1038/sj.ijo.0802038
   Wilson DK, 2002, PSYCHOSOM MED, V64, P906, DOI 10.1097/01.PSY.0000024234.11538.D3
   World Health Organization Mental Health Gap Action Programme World Health Organization Mental Health Gap Action Programme, 2015, UPD MENT HLTH GAP AC
NR 52
TC 10
Z9 10
U1 0
U2 4
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
EI 1097-6833
J9 J PEDIATR-US
JI J. Pediatr.
PD OCT
PY 2021
VL 237
BP 267
EP +
DI 10.1016/j.jpeds.2021.06.024
EA SEP 2021
PG 10
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA UV9QX
UT WOS:000699805300047
PM 34147498
DA 2025-06-11
ER

PT J
AU Babish, JG
   Dahlberg, CJ
   Ou, JJ
   Keller, WJ
   Gao, W
   Kaadige, MR
   Brabazon, H
   Lamb, J
   Soudah, HC
   Kou, XL
   Zhang, Z
   Pacioretty, LM
   Tripp, ML
AF Babish, John G.
   Dahlberg, Clinton J.
   Ou, Joseph J.
   Keller, William J.
   Gao, Wei
   Kaadige, Mohan R.
   Brabazon, Holly
   Lamb, Joseph
   Soudah, Hani C.
   Kou, Xiaolan
   Zhang, Zhe
   Pacioretty, Linda M.
   Tripp, Matthew L.
TI Synergistic in vitro antioxidant activity and observational clinical
   trial of F105, a phytochemical formulation including Citrus
   bergamia, in subjects with moderate cardiometabolic risk factors
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE cardiometabolic disease; bergamot; antioxidant; myeloperoxidase;
   oxidized LDL; dyslipidemia; HbA1c
ID LOW-DENSITY-LIPOPROTEIN; LIPID HYDROPEROXIDE; CHOLESTEROL RATIO;
   OXIDATIVE STRESS; POITEAU JUICE; OXIDIZED LDL; PAI-1; INFLAMMATION;
   ACTIVATION; EXPRESSION
AB We examined the clinical safety and efficacy of F105 in 11 subjects with moderate dyslipidemia. F105 is a combination of bergamot fruit extract (Citrus bergamia, BFE) and 9 phytoextracts selected for their ability to improve the antioxidant and anti-inflammatory activity of BFE. In vitro F105 exhibited a synergistic inhibition of oxygen radical absorbing capacity, peroxynitrite formation, and myeloperoxidase activity. Following 12 weeks of F105 daily, no treatment-related adverse events or changes in body mass were seen. Statistically significant changes were noted in total cholesterol (-7.3%), LDL-cholesterol (-10%), non-HDL cholesterol (-7.1%), cholesterol/HDL (-26%), and apolipoprotein B (-2.8%). A post hoc analysis of 8 subjects with HbA1c > 5.4 and HOMA-IR score > 2 or elevated triglycerides revealed additional statistically significant changes in addition to those previously observed in all subjects including triglycerides (-27%), oxLDL (-19%), LDL/HDL (-25%), triglycerides/HDL (-27%), oxLDL/HDL (-25%), and PAI-1 (-37%). A follow-up case report of a 70-year-old female patient, nonresponsive to statin therapy and placed on F105 daily, demonstrated improved cardiometabolic variables over 12 weeks similar to the subgroup. In summary, F105 was clinically well-tolerated and effective for ameliorating dyslipidemia in subjects with moderate cardiometabolic risk factors, particularly in the individuals with HbA1c > 5.4%.
C1 [Babish, John G.; Pacioretty, Linda M.] Bionexus Ltd, 53 Brown Rd,Suite B, Ithaca, NY 14850 USA.
   [Dahlberg, Clinton J.; Ou, Joseph J.; Keller, William J.; Gao, Wei; Kaadige, Mohan R.; Brabazon, Holly; Lamb, Joseph; Tripp, Matthew L.] Nat Sunshine Prod, Hughes Ctr Res & Innovat, 2500 Execut Pkwy, Lehi, UT 84043 USA.
   [Soudah, Hani C.] Tenet Healthcare Syst, Stella Maris Obes Med, 2315 Dougherty Ferry Rd,Suite 109, St Louis, MO 63122 USA.
   [Soudah, Hani C.] Washington Univ, Sch Med, 660 S Euclid Ave, St Louis, MO 63110 USA.
   [Kou, Xiaolan; Zhang, Zhe] Nat Sunshine Prod, 1655 North Main St, Spanish Fork, UT 84660 USA.
C3 Washington University (WUSTL)
RP Babish, JG (corresponding author), Bionexus Ltd, 53 Brown Rd,Suite B, Ithaca, NY 14850 USA.
EM jgb7@cornell.edu
OI Gao, Wei/0000-0003-0843-1449; Brabazon, Holly/0000-0001-8153-9363
FU Nature's Sunshine Products Inc., (NSP), Lehi, Utah
FX Financial support for this study was provided by Nature's Sunshine
   Products Inc., (NSP), Lehi, Utah. Joseph Lamb, Linda M. Pacioretty, and
   John G. Babish serve as consultants to NSP. Hani C. Soudah serves on the
   medical and scientific advisory board to NSP. All other authors are
   employees of NSP. The in vitro studies were conducted at Hughes Center
   For Research and Innovation Laboratories and Research Clinic, NSP. The
   clinical study was conducted at the High Desert Heart Institute,
   Victorville, California; we thank Siva Arunasalam and Dan Austin for
   conducting the clinical study. Recognition is given to members of the
   NSP Medical and Science Advisory Board, Ingrum Bankston Jr., Sang Geon
   Kim, and Luis N. Pacheco, for their critical review of this manuscript.
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alessi MC, 2004, ARCH MAL COEUR VAISS, V97, P673
   Bueyuekbalci A, 2008, PLANT FOOD HUM NUTR, V63, P27, DOI 10.1007/s11130-007-0065-5
   CHOU TC, 1984, ADV ENZYME REGUL, V22, P27, DOI 10.1016/0065-2571(84)90007-4
   COFFEY MD, 1995, J CLIN INVEST, V96, P1866, DOI 10.1172/JCI118232
   Cohen RM, 2010, J CLIN ENDOCR METAB, V95, P5203, DOI 10.1210/jc.2010-2352
   Currò M, 2016, SCI REP-UK, V6, DOI 10.1038/srep20809
   Dudonné S, 2009, J AGR FOOD CHEM, V57, P1768, DOI 10.1021/jf803011r
   Fujihara K, 2013, J ATHEROSCLER THROMB, V20, P452, DOI 10.5551/jat.14977
   Ginde AA, 2008, J GEN INTERN MED, V23, P1346, DOI 10.1007/s11606-008-0661-6
   Gliozzi M., 2014, J METAB SYNDR, V3, P143
   Gliozzi M., 2014, Advances in Biological Chemistry, V4, P129, DOI 10.4236/abc.2014.42017
   Hansson GK, 2006, ANNU REV PATHOL-MECH, V1, P297, DOI 10.1146/annurev.pathol.1.110304.100100
   Huang F, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054628
   Impellizzeri D, 2015, CLIN NUTR, V34, P1146, DOI 10.1016/j.clnu.2014.11.012
   Itabe H, 2011, J LIPIDS, V2011, DOI 10.1155/2011/418313
   Iwaki T, 2012, BRIT J HAEMATOL, V157, P291, DOI 10.1111/j.1365-2141.2012.09074.x
   Johnston N, 2006, AM J CARDIOL, V97, P640, DOI 10.1016/j.amjcard.2005.09.123
   Kaikkonen JE, 2016, FREE RADICAL RES, V50, P396, DOI 10.3109/10715762.2015.1133906
   Kim JY, 2008, J MED FOOD, V11, P21, DOI 10.1089/jmf.2007.040
   Li DY, 2003, CIRCULATION, V107, P612, DOI 10.1161/01.CIR.0000047276.52039.FB
   Lund TM, 2002, AM J CARDIOL, V90, P784, DOI 10.1016/S0002-9149(02)02614-0
   Mangge H, 2014, WORLD J CARDIOL, V6, P462, DOI 10.4330/wjc.v6.i6.462
   Mascarenhas-Melo F, 2013, SCI WORLD J, DOI 10.1155/2013/387849
   Miceli N, 2007, J AGR FOOD CHEM, V55, P10671, DOI 10.1021/jf071772i
   Mitra S, 2011, CARDIOVASC DRUG THER, V25, P419, DOI 10.1007/s10557-011-6341-5
   Mitra S, 2011, AM J MED SCI, V342, P135, DOI 10.1097/MAJ.0b013e318224a147
   Mollace V, 2008, J CARDIOVASC PHARM T, V13, P120, DOI 10.1177/1074248407313821
   Mollace V, 2011, FITOTERAPIA, V82, P309, DOI 10.1016/j.fitote.2010.10.014
   Picerno P, 2011, NAT PROD COMMUN, V6, P951
   Prior RL, 2003, J AGR FOOD CHEM, V51, P3273, DOI 10.1021/jf0262256
   Ramful D, 2010, TOXICOLOGY, V278, P75, DOI 10.1016/j.tox.2010.01.012
   Risitano R, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0107431
   Shen LJ, 2001, J LIPID RES, V42, P813
   Sicari V, 2016, INT J FOOD PROP, V19, P1962, DOI 10.1080/10942912.2015.1089893
   Song CY, 2005, KIDNEY INT, V67, P1743, DOI 10.1111/j.1523-1755.2005.00271.x
   Soory Mena, 2012, Infectious Disorders - Drug Targets, V12, P388
   Statti GA, 2004, FITOTERAPIA, V75, P212, DOI 10.1016/j.fitote.2003.12.002
   Stoner L, 2013, CLIN BIOCHEM, V46, P1353, DOI 10.1016/j.clinbiochem.2013.05.070
   Tekin IO, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/762759
   Thompson HJ, 2006, J NUTR, V136, P2207, DOI 10.1093/jn/136.8.2207
   Thum T, 2008, J BIOL CHEM, V283, P19456, DOI 10.1074/jbc.M708309200
   Trovato A, 2010, PHYTOTHER RES, V24, P514, DOI 10.1002/ptr.2971
   Tundis R, 2012, J FOOD SCI, V77, pH40, DOI 10.1111/j.1750-3841.2011.02511.x
   Vega GL, 2014, J INVEST MED, V62, P345, DOI 10.2310/JIM.0000000000000044
   Vulin AI, 2004, J BIOL CHEM, V279, P25172, DOI 10.1074/jbc.M403184200
   Wadley AJ, 2013, AGE, V35, P705, DOI 10.1007/s11357-012-9402-1
   Wallace A, 2003, BRIT MED J, V327, P788, DOI 10.1136/bmj.327.7418.788
   Weber C, 2011, NAT MED, V17, P1410, DOI 10.1038/nm.2538
   Yamamoto K, 2014, SEMIN THROMB HEMOST, V40, P652, DOI 10.1055/s-0034-1384635
   Yunke Z, 2014, HERZ, V39, P105, DOI 10.1007/s00059-013-3788-0
   Zhuo XH, 2012, AM J PREV MED, V42, P374, DOI 10.1016/j.amepre.2012.01.003
   Zonszein J, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/129891
NR 53
TC 15
Z9 15
U1 0
U2 9
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD DEC
PY 2016
VL 94
IS 12
BP 1257
EP 1266
DI 10.1139/cjpp-2016-0062
PG 10
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA EC4JS
UT WOS:000388095500003
PM 27463949
OA hybrid
DA 2025-06-11
ER

PT J
AU Brea, A
   Puzo, J
AF Brea, Angel
   Puzo, Jose
TI Non-alcoholic fatty liver disease and cardiovascular risk
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Review
DE Fatty liver; Cardiovascular disease; Alcohol; Non-alcoholic fatty liver
   disease
ID GAMMA-GLUTAMYL-TRANSFERASE; CORONARY-HEART-DISEASE; TRIGLYCERIDE
   TRANSFER PROTEIN; ENDOPLASMIC-RETICULUM STRESS; RANDOMIZED
   CONTROLLED-TRIAL; TERM-FOLLOW-UP; HEPATIC STEATOSIS; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; WEIGHT-LOSS
AB The term "Non-alcoholic fatty liver disease" (NAFLD) covers a series of liver lesions similar to those induced by alcohol, but not caused by alcohol use. The importance of NAFLD lies in the high prevalence in Western societies and, from the point of view of the liver, in its progression from steatosis to cirrhosis and liver cancer. More recently, NAFLD has been found to be associated with lipid metabolism disorders, the deposition of fat outside of the adipocytes, insulin resistance and Metabolic Syndrome. Also attributed to NAFLD is a heightened systemic pro-inflammatory state, which accelerates arteriosclerosis, thereby increasing cardiovascular risk and associated cardiovascular events. Here we provide an update to the etiopathogenesis of NAFLD, its influence on cardiovascular disease, and the treatment options. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
C1 [Brea, Angel] Hosp San Pedro, Unidad Lipidos, Serv Med Interna, Logrono, Spain.
   [Puzo, Jose] Hosp San Jorge, Unidad Lipidos, Bioquim Clin, Huesca, Spain.
C3 Hospital Universidad San Jorge
RP Puzo, J (corresponding author), Hosp Gen San Jorge, Unidad Lipidos, Bioquim Clin, P Martinez Velasco 36, Huesca 22004, Spain.
EM jpuzo@unizar.es
RI Puzo Foncillas, Jose/AAE-5827-2021
OI Puzo Foncillas, Jose/0000-0002-1309-4363
CR Adams LA, 2005, GASTROENTEROLOGY, V129, P113, DOI 10.1053/j.gastro.2005.04.014
   Adams LA, 2011, J DIGEST DIS, V12, P10, DOI 10.1111/j.1751-2980.2010.00471.x
   Adams LA, 2010, AM J GASTROENTEROL, V105, P1567, DOI 10.1038/ajg.2010.18
   Adiels M, 2006, DIABETOLOGIA, V49, P755, DOI 10.1007/s00125-005-0125-z
   Alkhouri N, 2010, DIGEST DIS SCI, V55, P2644, DOI 10.1007/s10620-009-1075-y
   ANDERSEN T, 1991, J HEPATOL, V12, P224, DOI 10.1016/0168-8278(91)90942-5
   Angulo P, 2002, NEW ENGL J MED, V346, P1221, DOI 10.1038/nrdp.2015.80
   Antonopoulos S, 2006, ATHEROSCLEROSIS, V184, P233, DOI 10.1016/j.atherosclerosis.2005.08.021
   Arslan U, 2007, CORONARY ARTERY DIS, V18, P433, DOI 10.1097/MCA.0b013e3282583c0d
   Assy N, 2000, DIGEST DIS SCI, V45, P1929, DOI 10.1023/A:1005661516165
   Assy N, 2010, RADIOLOGY, V254, P393, DOI 10.1148/radiol.09090769
   Athyros VG, 2006, CURR MED RES OPIN, V22, P873, DOI 10.1185/030079906X104696
   Athyros VG, 2010, LANCET, V376, P1916, DOI 10.1016/S0140-6736(10)61272-X
   Basaranoglu M, 1999, J HEPATOL, V31, P384, DOI 10.1016/S0168-8278(99)80243-8
   Bedogni G, 2007, HEPATOLOGY, V46, P1387, DOI 10.1002/hep.21827
   Bedogni G, 2006, BMC GASTROENTEROL, V6, DOI 10.1186/1471-230X-6-33
   Belfort R, 2006, NEW ENGL J MED, V355, P2297, DOI 10.1056/NEJMoa060326
   Bernard S, 2000, DIABETOLOGIA, V43, P995, DOI 10.1007/s001250051481
   Brea A, 2005, ARTERIOSCL THROM VAS, V25, P1045, DOI 10.1161/01.ATV.0000160613.57985.18
   Brea A, 2002, ATHEROSCLEROSIS SUPP, V3, P79
   Brea A, 2002, ATHEROSCLEROSIS SUPP, V3, P80
   Browning JD, 2004, HEPATOLOGY, V40, P1387, DOI 10.1002/hep.20466
   Bugianesi E, 2005, AM J GASTROENTEROL, V100, P1082, DOI 10.1111/j.1572-0241.2005.41583.x
   Cales P, 2010, LIVER INT, V30, P1400
   Carulli L, 2006, HEPATOLOGY, V44, P278, DOI 10.1002/hep.21218
   Cayón A, 2008, REV ESP ENFERM DIG, V100, P212, DOI 10.4321/s1130-01082008000400004
   Chalasani N, 2004, GASTROENTEROLOGY, V126, P1287, DOI 10.1053/j.gastro.2004.02.015
   Charlton N, 2002, HEPATOLOGY, V35, P898, DOI 10.1053/jhep.2002.32527
   Choi CS, 2007, J BIOL CHEM, V282, P22678, DOI 10.1074/jbc.M704213200
   Choi SS, 2008, CURR OPIN LIPIDOL, V19, P295, DOI 10.1097/MOL.0b013e3282ff5e55
   Dam-Larsen S, 2004, GUT, V53, P750, DOI 10.1136/gut.2003.019984
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   De Ledinghen V, 2012, DIGEST LIVER DIS, V44, P413, DOI 10.1016/j.dld.2011.12.005
   de Lédinghen V, 2010, EXPERT REV MED DEVIC, V7, P811, DOI [10.1586/erd.10.46, 10.1586/ERD.10.46]
   Dixon JB, 2001, GASTROENTEROLOGY, V121, P91, DOI 10.1053/gast.2001.25540
   Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI23621
   Dowman JK, 2011, ALIMENT PHARM THER, V33, P525, DOI 10.1111/j.1365-2036.2010.04556.x
   Dunn W, 2008, AM J GASTROENTEROL, V103, P2263, DOI 10.1111/j.1572-0241.2008.02034.x
   Dunn W, 2008, HEPATOLOGY, V47, P1947, DOI 10.1002/hep.22292
   Duvnjak M, 2007, WORLD J GASTROENTERO, V13, P4539, DOI 10.3748/wjg.v13.i34.4539
   Ekstedt M, 2006, HEPATOLOGY, V44, P865, DOI 10.1002/hep.21327
   Ekstedt M, 2009, SCAND J GASTROENTERO, V44, P366, DOI 10.1080/00365520802555991
   Ekstedt M, 2007, J HEPATOL, V47, P135, DOI 10.1016/j.jhep.2007.02.013
   Elias MC, 2010, NUTRITION, V26, P1094, DOI 10.1016/j.nut.2009.09.001
   Enjoji M, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-29
   Erridge C, 2011, ATHEROSCLEROSIS, V216, P1, DOI 10.1016/j.atherosclerosis.2011.02.043
   Fan JG, 2007, J GASTROEN HEPATOL, V22, P1086, DOI 10.1111/j.1440-1746.2006.04781.x
   Fracanzani AL, 2008, AM J MED, V121, P72, DOI 10.1016/j.amjmed.2007.08.041
   Friis-Liby I, 2004, SCAND J GASTROENTERO, V39, P864, DOI 10.1080/00365520410006431
   Gambino R, 2007, HEPATOLOGY, V45, P1097, DOI 10.1002/hep.21631
   Gastaldelli A, 2009, HEPATOLOGY, V49, P1537, DOI 10.1002/hep.22845
   Goland S, 2006, J CLIN GASTROENTEROL, V40, P949, DOI 10.1097/01.mcg.0000225668.53673.e6
   Gregor MF, 2009, DIABETES, V58, P693, DOI 10.2337/db08-1220
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Hamaguchi M, 2005, ANN INTERN MED, V143, P722, DOI 10.7326/0003-4819-143-10-200511150-00009
   Hamaguchi M, 2007, WORLD J GASTROENTERO, V13, P1579, DOI 10.3748/wjg.v13.i10.1579
   Harrison SA, 2004, ALIMENT PHARM THERAP, V20, P623, DOI 10.1111/j.1365-2036.2004.02153.x
   Harrison SA, 2003, AM J GASTROENTEROL, V98, P2485, DOI 10.1111/j.1572-0241.2003.08699.x
   Hickman IJ, 2004, GUT, V53, P413, DOI 10.1136/gut.2003.027581
   Horton JD, 1999, J CLIN INVEST, V103, P1067, DOI 10.1172/JCI6246
   Hussein O, 2007, DIGEST DIS SCI, V52, P2512, DOI 10.1007/s10620-006-9631-1
   Ioannou GN, 2006, HEPATOLOGY, V43, P1145, DOI 10.1002/hep.21171
   Iwasaki T, 2011, HEPATO-GASTROENTEROL, V58, P2103, DOI 10.5754/hge11263
   Jepsen P, 2003, HEPATO-GASTROENTEROL, V50, P2101
   Jou J, 2008, SEMIN LIVER DIS, V28, P370, DOI 10.1055/s-0028-1091981
   Koruk M, 2003, J CLIN GASTROENTEROL, V37, P177, DOI 10.1097/00004836-200308000-00017
   Kotronen A, 2008, ARTERIOSCL THROM VAS, V28, P27, DOI 10.1161/ATVBAHA.107.147538
   Lazo M, 2008, SEMIN LIVER DIS, V28, P339, DOI 10.1055/s-0028-1091978
   Lazo M, 2010, DIABETES CARE, V33, P2156, DOI 10.2337/dc10-0856
   Lee DS, 2007, ARTERIOSCL THROM VAS, V27, P127, DOI 10.1161/01.ATV.0000251993.20372.40
   Lee DH, 2006, EUR HEART J, V27, P2170, DOI 10.1093/eurheartj/ehl086
   LEE RG, 1989, HUM PATHOL, V20, P594, DOI 10.1016/0046-8177(89)90249-9
   Lin YC, 2005, WORLD J GASTROENTERO, V11, P4838, DOI 10.3748/wjg.v11.i31.4838
   Lindor KD, 2004, HEPATOLOGY, V39, P770, DOI 10.1002/hep.20092
   Liu Q, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-42
   Lu HY, 2009, ARCH MED RES, V40, P571, DOI 10.1016/j.arcmed.2009.07.009
   LUDWIG J, 1980, MAYO CLIN PROC, V55, P434
   Magkos F, 2010, CURR OPIN LIPIDOL, V21, P507, DOI 10.1097/MOL.0b013e32833ea912
   Marchesini G, 2005, CURR OPIN LIPIDOL, V16, P421, DOI 10.1097/01.mol.0000174153.53683.f2
   Marchesini G, 2003, HEPATOLOGY, V37, P917, DOI 10.1053/jhep.2003.50161
   Marchesini G, 1999, AM J MED, V107, P450, DOI 10.1016/S0002-9343(99)00271-5
   Marchesini G, 2001, DIABETES, V50, P1844, DOI 10.2337/diabetes.50.8.1844
   Marchesini G, 2001, LANCET, V358, P893, DOI 10.1016/S0140-6736(01)06042-1
   Mattar SG, 2005, ANN SURG, V242, P610, DOI 10.1097/01.sla.0000179652.07502.3f
   Matteoni CA, 1999, GASTROENTEROLOGY, V116, P1413, DOI 10.1016/S0016-5085(99)70506-8
   McLaughlin T, 2005, AM J CARDIOL, V96, P399, DOI 10.1016/j.amjcard.2005.03.085
   Miele L, 2009, HEPATOLOGY, V49, P1877, DOI 10.1002/hep.22848
   Mishra P, 2007, AM J GASTROENTEROL, V102, P2716, DOI 10.1111/j.1572-0241.2007.01520.x
   Monetti M, 2007, CELL METAB, V6, P69, DOI 10.1016/j.cmet.2007.05.005
   Musso G, 2008, DIABETES CARE, V31, P562, DOI 10.2337/dc07-1526
   Nair S, 2004, ALIMENT PHARM THERAP, V20, P23, DOI 10.1111/j.1365-2036.2004.02025.x
   Neuschwander-Tetri BA, 2003, HEPATOLOGY, V38, P1008, DOI 10.1053/jhep.2003.50420
   Neuschwander-Tetri BA, 2003, HEPATOLOGY, V37, P1202, DOI 10.1053/jhep.2003.50193
   NOMURA H, 1988, JPN J MED, V27, P142, DOI 10.2169/internalmedicine1962.27.142
   Okumura K, 2009, METABOLISM, V58, P1306, DOI 10.1016/j.metabol.2009.04.013
   Ong JP, 2008, J HEPATOL, V49, P608, DOI 10.1016/j.jhep.2008.06.018
   Palmentieri B, 2006, DIGEST LIVER DIS, V38, P485, DOI 10.1016/j.dld.2006.03.021
   Papandreou D, 2007, CLIN NUTR, V26, P409, DOI 10.1016/j.clnu.2007.02.002
   Park H, 2011, J GASTROENTEROL, V46, P101, DOI 10.1007/s00535-010-0291-8
   Park SY, 2009, J PHARMACOL EXP THER, V329, P571, DOI 10.1124/jpet.108.146456
   Parker HM, 2012, J HEPATOL, V56, P944, DOI 10.1016/j.jhep.2011.08.018
   Pascale A, 2010, J GASTROINTEST LIVER, V19, P415
   Perseghin G, 2008, HEPATOLOGY, V47, P51, DOI 10.1002/hep.21983
   Petersen KF, 2010, NEW ENGL J MED, V362, P1082, DOI 10.1056/NEJMoa0907295
   Promrat K, 2010, HEPATOLOGY, V51, P121, DOI 10.1002/hep.23276
   Rafiq N, 2009, CLIN GASTROENTEROL H, V7, P234, DOI 10.1016/j.cgh.2008.11.005
   Rakoski MO, 2010, ALIMENT PHARM THER, V32, P1211, DOI 10.1111/j.1365-2036.2010.04467.x
   Ramesh S, 2004, SEMIN LIVER DIS, V24, P399, DOI 10.1055/s-2004-860869
   Ratziu V, 2000, GASTROENTEROLOGY, V118, P1117, DOI 10.1016/S0016-5085(00)70364-7
   Ratziu V, 2010, J HEPATOL, V53, P372, DOI 10.1016/j.jhep.2010.04.008
   Ratziu V, 2010, HEPATOLOGY, V51, P445, DOI 10.1002/hep.23270
   Ruttmann E, 2005, CIRCULATION, V112, P2130, DOI 10.1161/CIRCULATIONAHA.105.552547
   Sanyal AJ, 2006, HEPATOLOGY, V43, P682, DOI 10.1002/hep.21103
   Sanyal AJ, 2001, GASTROENTEROLOGY, V120, P1183, DOI 10.1053/gast.2001.23256
   Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929
   Satapathy SK, 2007, J GASTROEN HEPATOL, V22, P634, DOI 10.1111/j.1440-1746.2006.04756.x
   Schindhelm RK, 2007, ATHEROSCLEROSIS, V191, P391, DOI 10.1016/j.atherosclerosis.2006.04.006
   Schwenzer NF, 2009, J HEPATOL, V51, P433, DOI 10.1016/j.jhep.2009.05.023
   Schwimmer JB, 2005, HEPATOLOGY, V42, p610A
   Shoelson SE, 2007, GASTROENTEROLOGY, V132, P2169, DOI 10.1053/j.gastro.2007.03.059
   Sookoian S, 2008, J HEPATOL, V49, P600, DOI 10.1016/j.jhep.2008.06.012
   Speliotes EK, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1001324
   Speliotes EK, 2010, HEPATOLOGY, V51, P1979, DOI 10.1002/hep.23593
   STAMPFER MJ, 1991, NEW ENGL J MED, V325, P373, DOI 10.1056/NEJM199108083250601
   Stein LL, 2009, ADV THER, V26, P893, DOI 10.1007/s12325-009-0072-z
   Sung KC, 2009, ATHEROSCLEROSIS, V203, P581, DOI 10.1016/j.atherosclerosis.2008.07.024
   Sung KC, 2011, J CLIN ENDOCR METAB, V96, P1093, DOI 10.1210/jc.2010-2190
   Tamura S, 2005, J CLIN INVEST, V115, P1139, DOI 10.1172/JCI200524930
   Tarantino G, 2007, J GASTROEN HEPATOL, P22293
   Targher G, 2008, DIABETOLOGIA, V51, P444, DOI 10.1007/s00125-007-0897-4
   Targher G, 2006, DIABETIC MED, V23, P403, DOI 10.1111/j.1464-5491.2006.01817.x
   Targher G, 2005, DIABETES, V54, P3541, DOI 10.2337/diabetes.54.12.3541
   Targher G, 2004, DIABETES CARE, V27, P2498, DOI 10.2337/diacare.27.10.2498
   Targher G, 2008, OBESITY, V16, P1394, DOI 10.1038/oby.2008.64
   Targher G, 2007, DIABETES CARE, V30, P2119, DOI 10.2337/dc07-0349
   Targher G, 2007, ATHEROSCLEROSIS, V191, P235, DOI 10.1016/j.atherosclerosis.2006.08.021
   Targher G, 2006, DIABETES CARE, V29, P1325, DOI 10.2337/dc06-0135
   Targher G, 2010, NEW ENGL J MED, V363, P1341, DOI 10.1056/NEJMra0912063
   Toledo FGS, 2006, DIABETES CARE, V29, P1845, DOI 10.2337/dc06-0455
   Treeprasertsuk S, 2011, DIGEST DIS SCI, V56, P35, DOI 10.1007/s10620-010-1241-2
   Ueno T, 1997, J HEPATOL, V27, P103, DOI 10.1016/S0168-8278(97)80287-5
   Velayudham A, 2009, HEPATOLOGY, V49, P989, DOI 10.1002/hep.22711
   Verna EC, 2008, SEMIN LIVER DIS, V28, P407, DOI 10.1055/s-0028-1091985
   Villanova N, 2005, HEPATOLOGY, V42, P473, DOI 10.1002/hep.20781
   Völzke H, 2005, WORLD J GASTROENTERO, V11, P1848
   Wang D, 2006, ENDOCRINOLOGY, V147, P943, DOI 10.1210/en.2005-0570
   WANNAMETHEE G, 1995, AM J EPIDEMIOL, V142, P699, DOI 10.1093/oxfordjournals.aje.a117699
   Watt MJ, 2009, CLIN EXP PHARMACOL P, V36, P5, DOI 10.1111/j.1440-1681.2008.05075.x
   Westerbacka J, 2005, J CLIN ENDOCR METAB, V90, P2804, DOI 10.1210/jc.2004-1983
   Wieckowska A, 2008, SEMIN LIVER DIS, V28, P386, DOI 10.1055/s-0028-1091983
   Wieckowska A, 2007, HEPATOLOGY, V46, P582, DOI 10.1002/hep.21768
   Williams CD, 2011, GASTROENTEROLOGY, V140, P124, DOI 10.1053/j.gastro.2010.09.038
   Willner IR, 2001, AM J GASTROENTEROL, V96, P2957
   Wilson PWF, 2005, CIRCULATION, V112, P3066, DOI 10.1161/CIRCULATIONAHA.105.539528
   Yokohama S, 2004, HEPATOLOGY, V40, P1222, DOI 10.1002/hep.20420
   Yoneda M, 2010, HEPATOL RES, V40, P566, DOI 10.1111/j.1872-034X.2010.00644.x
   ZELMAN S, 1952, ARCH INTERN MED, V90, P141, DOI 10.1001/archinte.1952.00240080007002
NR 157
TC 77
Z9 85
U1 1
U2 28
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD AUG 20
PY 2013
VL 167
IS 4
BP 1109
EP 1117
DI 10.1016/j.ijcard.2012.09.085
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 206ZV
UT WOS:000323566800017
PM 23141876
DA 2025-06-11
ER

PT J
AU Babtan, AM
   Ilea, A
   Bosca, BA
   Crisan, M
   Petrescu, NB
   Collino, M
   Sainz, RM
   Gerlach, JQ
   Câmpian, RS
AF Babtan, Anida M.
   Ilea, Aranka
   Bosca, Bianca A.
   Crisan, Maria
   Petrescu, Nausica B.
   Collino, Massimo
   Sainz, Rosa M.
   Gerlach, Jared Q.
   Campian, Radu S.
TI Advanced glycation end products as biomarkers in systemic diseases:
   premises and perspectives of salivary advanced glycation end products
SO BIOMARKERS IN MEDICINE
LA English
DT Review
DE advanced glycation end products; AGEs; AGEs diagnosis and
   downregulation; biomarkers; biosensor; chronic low-level inflammation;
   diet-related disease; metabolic syndrome; metainflammation; saliva
ID MAILLARD REACTION; RISK-FACTOR; PROTEIN GLYCATION; OXIDATIVE STRESS;
   PERIODONTITIS PATIENTS; INCREASED ACCUMULATION; CARBOXYMETHYL-LYSINE;
   DIETARY GLYCOTOXINS; CALORIC RESTRICTION; LIPID-PEROXIDATION
AB Advanced glycation end products (AGEs) are glycated proteins associated with high dry temperature food processing, coloring and flavor modification of food products. Previous studies on diet-related disease support the role of the glycation products as biomarkers in local and general proinflammatory response. Exogenous and endogenous AGEs are involved in chronic low-level inflammation, which underlies the onset of metabolic syndrome influenced by food intake, there by demonstrating their implication in diet-related pathologies. Although studies have revealed a strong association between the accumulation of AGEs and the occurrence/ worsening of metabolic diseases, their routine use for the diagnosis or monitoring of local and general disease has not yet been reported.
   [GRAPHICS]
   .
C1 [Babtan, Anida M.; Ilea, Aranka; Petrescu, Nausica B.; Campian, Radu S.] Iuliu Hatieganu Univ Med & Pharm, Fac Dent, Oral Hlth & Dent Off Management, Dept Oral Rehabil, Victor Babes St, Cluj Napoca 400012, Romania.
   [Bosca, Bianca A.; Crisan, Maria] Iuliu Hatieganu Univ Med & Pharm, Dept Histol, Louis Pasteur St 4, Cluj Napoca 400349, Romania.
   [Collino, Massimo] Univ Turin, Dept Drug Sci & Technol, Corso Raffaello 33, I-10125 Turin, Italy.
   [Sainz, Rosa M.] Univ Oviedo, Dept Morphol & Cell Biol, Campus Cristo C Julian Claveria 6, E-33006 Oviedo, Spain.
   [Gerlach, Jared Q.] Natl Univ Ireland Galway, Natl Ctr Biomed Engn Sci, Glycosci Grp, Galway H91 CF50, Ireland.
C3 Iuliu Hatieganu University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy; University of Turin; University of
   Oviedo
RP Bosca, BA (corresponding author), Iuliu Hatieganu Univ Med & Pharm, Dept Histol, Louis Pasteur St 4, Cluj Napoca 400349, Romania.
EM biancabosca@yahoo.com
RI Boșca, Bianca/AAS-7779-2021; crisan, maria/AAA-8119-2021; Ilea,
   Aranka/N-6040-2014; Collino, Massimo/AAK-8532-2020; Babtan,
   Anida-Maria/AAO-2548-2020; Petrescu, Nausica/ABA-2480-2022; Sainz, Rosa
   M./N-5885-2014; Gerlach, Jared/K-2698-2013
OI Sainz, Rosa M./0000-0003-3048-5582; Gerlach, Jared/0000-0001-7343-7201;
   Bosca, Adina Bianca/0000-0002-3835-2090
FU 'Iuliu Hatieganu' University of Medicine and Pharmacy Cluj-Napoca,
   Romania [3999/01.10.2016]; COFUND-ERA-HDHL ERANET Project, European and
   International Cooperation - Subprogram 3.2 -Horizon 2020, PNCDI III
   Program - Biomarkers for Nutrition and Health - 'Innovative
   technological approaches for validation of salivary AGEs as novel
   biomarkers in eva [25/1.09.2017]
FX This study was supported by 'Iuliu Hatieganu' University of Medicine and
   Pharmacy Cluj-Napoca, Romania PhD grant no. 3999/01.10.2016, and
   partially by the COFUND-ERA-HDHL ERANET Project, European and
   International Cooperation - Subprogram 3.2 -Horizon 2020, PNCDI III
   Program - Biomarkers for Nutrition and Health - 'Innovative
   technological approaches for validation of salivary AGEs as novel
   biomarkers in evaluation of risk factors in diet-related diseases',
   grant no. 25/1.09.2017. The authors have no other relevant affiliations
   or financial involvement with any organization or entity with a
   financial interest in or financial conflict with the subject matter or
   materials discussed in the manuscript apart from those disclosed.
CR Abe R, 2008, CURR PHARM DESIGN, V14, P940, DOI 10.2174/138161208784139765
   Ahmad S, 2018, SEMIN CANCER BIOL, V49, P44, DOI 10.1016/j.semcancer.2017.07.001
   Alamir I, 2013, AMINO ACIDS, V44, P1441, DOI 10.1007/s00726-012-1427-3
   [Anonymous], DIS MARK
   Aragno M, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040385
   Nguyen AH, 2017, ANTICANCER RES, V37, P1, DOI 10.21873/anticanres.11282
   Behuliak M, 2009, DIS MARKERS, V26, P49, DOI [10.1155/2009/175683, 10.3233/DMA-2009-0606]
   Bhawal UK, 2005, ONCOLOGY-BASEL, V69, P246, DOI 10.1159/000087910
   Birlouez-Aragon I, 2010, AM J CLIN NUTR, V91, P1220, DOI 10.3945/ajcn.2009.28737
   Brings S, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18050984
   Brownlee M, 2000, METABOLISM, V49, P9, DOI 10.1016/S0026-0495(00)80078-5
   BUNN HF, 1981, SCIENCE, V213, P222, DOI 10.1126/science.12192669
   CEFALU WT, 1995, J GERONTOL A-BIOL, V50, pB337, DOI 10.1093/gerona/50A.6.B337
   Cerami C, 1997, P NATL ACAD SCI USA, V94, P13915, DOI 10.1073/pnas.94.25.13915
   Ciui BC, 2019, SENSOR ACTUAT B-CHEM, V281, P399, DOI 10.1016/j.snb.2018.10.096
   Couppé C, 2014, AGE, V36, DOI 10.1007/s11357-014-9665-9
   Cozma AI, 2012, DIABETES CARE, V35, P1611, DOI 10.2337/dc12-0073
   Crisan M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0075003
   Dahl A, 2010, J GERONTOL A-BIOL, V65, P57, DOI 10.1093/gerona/glp035
   Danaei G, 2011, LANCET, V378, P31, DOI 10.1016/S0140-6736(11)60679-X
   Delgado-Andrade C, 2018, ANNU REV FOOD SCI T, V9, P271, DOI 10.1146/annurev-food-030117-012441
   den Engelsen C, 2012, DERM-ENDOCRINOL, V4, P33, DOI 10.4161/derm.17999
   Deo P, 2017, INT J ENV RES PUB HE, V14, P1
   Duan ZG, 2014, INT J MOL EPIDEMIOL, V5, P152
   Engebretson SP, 2011, PHARMACOL RES, V64, P624, DOI 10.1016/j.phrs.2011.06.024
   ERBERSDOBLER HF, 1991, Z ERNAHRUNGSWISS, V30, P46, DOI 10.1007/BF01910731
   FINOT PA, 1981, PROG FOOD NUTR SCI, V5, P193
   FINOT PA, 1972, HELV CHIM ACTA, V55, P1153, DOI 10.1002/hlca.19720550411
   Fogliano V, 2011, FOOD FUNCT, V2, P117, DOI 10.1039/c0fo00156b
   Förster A, 2005, ANN NY ACAD SCI, V1043, P474, DOI 10.1196/annals.1333.054
   Frenkel ES, 2015, APPL ENVIRON MICROB, V81, P332, DOI 10.1128/AEM.02573-14
   Gaens KHJ, 2014, ARTERIOSCL THROM VAS, V34, P1199, DOI 10.1161/ATVBAHA.113.302281
   Gaens KHJ, 2012, J HEPATOL, V56, P647, DOI 10.1016/j.jhep.2011.07.028
   Gaens KHJ, 2009, J CLIN ENDOCR METAB, V94, P5174, DOI 10.1210/jc.2009-1067
   Gallo A, 2018, INT J CARDIOL, V273, P230, DOI 10.1016/j.ijcard.2018.10.005
   Garay-Sevilla ME, 2005, J ENDOCRINOL INVEST, V28, P223, DOI 10.1007/BF03345377
   Gautieri A, 2017, MATRIX BIOL, V59, P95, DOI 10.1016/j.matbio.2016.09.001
   Gibbins HL, 2014, ORAL DIS, V20, P707, DOI 10.1111/odi.12194
   Goldberg T, 2004, J AM DIET ASSOC, V104, P1287, DOI 10.1016/j.jada.2004.05.214
   Goon JA, 2009, J PHYS ACT HEALTH, V6, P43, DOI 10.1123/jpah.6.1.43
   Grauballe MB, 2017, J PERIODONTAL RES, V52, P97, DOI 10.1111/jre.12373
   Guentsch A, 2008, CLIN ORAL INVEST, V12, P345, DOI 10.1007/s00784-008-0202-z
   Guilbaud A, 2016, FOODS, V5, DOI 10.3390/foods5040084
   Macías-Cervantes MH, 2015, NUTRITION, V31, P446, DOI 10.1016/j.nut.2014.10.004
   Hayashi N, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0070034
   Helou C, 2016, FOOD FUNCT, V7, P2498, DOI [10.1039/c5fo01341k, 10.1039/C5FO01341K]
   HODGE JE, 1953, J AGR FOOD CHEM, V1, P928, DOI 10.1021/jf60015a004
   Holte KB, 2017, J DIABETES COMPLICAT, V31, P1408, DOI 10.1016/j.jdiacomp.2017.06.007
   Hsu TM, 2015, HIPPOCAMPUS, V25, P227, DOI 10.1002/hipo.22368
   Hull GLJ, 2012, FOOD CHEM, V131, P170, DOI 10.1016/j.foodchem.2011.08.055
   Ilea A, 2018, ARCH ORAL BIOL, V93, P22, DOI 10.1016/j.archoralbio.2018.05.013
   Javadi S, 2017, J BIOMOL STRUCT DYN, V35, P1766, DOI 10.1080/07391102.2016.1194230
   Karim L, 2013, OSTEOPOROSIS INT, V24, P2441, DOI 10.1007/s00198-013-2319-4
   Kataoka K, 2012, ONCOL LETT, V3, P1149, DOI 10.3892/ol.2012.612
   Kim Chan-Sik, 2017, J Exerc Nutrition Biochem, V21, P55, DOI 10.20463/jenb.2017.0027
   KONDOH Y, 1992, EUR J APPL PHYSIOL O, V65, P88, DOI 10.1007/BF01466280
   Koschinsky T, 1997, P NATL ACAD SCI USA, V94, P6474, DOI 10.1073/pnas.94.12.6474
   Koyama Y, 2007, J CARD FAIL, V13, P199, DOI 10.1016/j.cardfail.2006.11.009
   Lakhan SE, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-114
   LEE AT, 1987, P NATL ACAD SCI USA, V84, P8311, DOI 10.1073/pnas.84.23.8311
   Lettrichova I, 2015, THESIS
   Levi B, 1998, J NUTR, V128, P1442, DOI 10.1093/jn/128.9.1442
   Li L, 2012, MOLECULES, V17, P12758, DOI 10.3390/molecules171112758
   Li M, 2015, J AGR FOOD CHEM, V63, P1658, DOI 10.1021/jf505063t
   Lian WW, 2017, FRONT AGING NEUROSCI, V9, DOI 10.3389/fnagi.2017.00409
   Liao YF, 2018, MOL MED REP, V17, P8536, DOI 10.3892/mmr.2018.8914
   Lo CY, 2006, MOL NUTR FOOD RES, V50, P1118, DOI 10.1002/mnfr.200600094
   Löbner J, 2015, J AGR FOOD CHEM, V63, P2249, DOI 10.1021/jf505998z
   Maessen MFH, 2017, J SCI MED SPORT, V20, P921, DOI 10.1016/j.jsams.2017.03.011
   Mahajan N, 2013, INT J CARDIOL, V168, P1788, DOI 10.1016/j.ijcard.2013.05.013
   Bastos DHM, 2015, CURR OPIN FOOD SCI, V1, P13, DOI 10.1016/j.cofs.2014.08.001
   Mastrocola R, 2016, NEUROBIOL DIS, V89, P65, DOI 10.1016/j.nbd.2016.02.005
   Mastrocola R, 2013, AM J PHYSIOL-GASTR L, V305, pG398, DOI 10.1152/ajpgi.00450.2012
   Mehta BM, 2016, COMPR REV FOOD SCI F, V15, P206, DOI 10.1111/1541-4337.12178
   MONNIER VM, 1984, P NATL ACAD SCI-BIOL, V81, P583, DOI 10.1073/pnas.81.2.583
   Morales FJ, 2012, AMINO ACIDS, V42, P1097, DOI 10.1007/s00726-010-0774-1
   NEEPER M, 1992, J BIOL CHEM, V267, P14998
   Neviere R, 2016, GLYCOCONJUGATE J, V33, P607, DOI 10.1007/s10719-016-9679-x
   Nguyen CV, 2006, MOL NUTR FOOD RES, V50, P1140, DOI 10.1002/mnfr.200600144
   Niquet-Léridon C, 2011, FOOD CHEM, V126, P655, DOI 10.1016/j.foodchem.2010.10.111
   Nowotny K, 2018, FREE RADICAL BIO MED, V120, P102, DOI 10.1016/j.freeradbiomed.2018.03.022
   OBRIEN JD, 1989, GUT, V30, P1530, DOI 10.1136/gut.30.11.1530
   Poulsen MW, 2016, BRIT J NUTR, V115, P629, DOI 10.1017/S0007114515004833
   Pusterla T, 2013, HEPATOLOGY, V58, P363, DOI 10.1002/hep.26395
   Quan KK, 2014, J DERMATOL SCI, V73, P166, DOI 10.1016/j.jdermsci.2013.10.001
   RAHBAR S, 1969, BIOCHEM BIOPH RES CO, V36, P838, DOI 10.1016/0006-291X(69)90685-8
   Sadowska-Bartosz I, 2015, MOLECULES, V20, P3309, DOI 10.3390/molecules20023309
   Sakaguchi M, 2017, ACTA MED OKAYAMA, V71, P459, DOI 10.18926/AMO/55582
   Sanders NT, 2017, ARCH ORAL BIOL, V80, P95, DOI 10.1016/j.archoralbio.2017.03.021
   Sasahira T, 2007, HISTOPATHOLOGY, V51, P166, DOI 10.1111/j.1365-2559.2007.02739.x
   Sasahira T, 2008, CANCER SCI, V99, P1806, DOI 10.1111/j.1349-7006.2008.00894.x
   Scheijen JLJM, 2018, CLIN NUTR, V37, P919, DOI 10.1016/j.clnu.2017.03.019
   Scheijen JLJM, 2016, FOOD CHEM, V190, P1145, DOI 10.1016/j.foodchem.2015.06.049
   Schleicher ED, 1997, J CLIN INVEST, V99, P457, DOI 10.1172/JCI119180
   Sculley DV, 2003, CLIN SCI, V105, P167, DOI 10.1042/CS20030031
   Sell DR, 2003, J GERONTOL A-BIOL, V58, P508
   Semba RD, 2014, J NUTR, V144, P1037, DOI 10.3945/jn.113.189480
   Seneff S, 2011, EUR J INTERN MED, V22, P134, DOI 10.1016/j.ejim.2010.12.017
   Shuvaev VV, 2001, NEUROBIOL AGING, V22, P397, DOI 10.1016/S0197-4580(00)00253-0
   Sievenpiper JL, 2012, ANN INTERN MED, V156, P291, DOI 10.7326/0003-4819-156-4-201202210-00007
   Sievenpiper JL, 2009, DIABETES CARE, V32, P1930, DOI 10.2337/dc09-0619
   Sponder M, 2018, HEART VESSELS, V33, P893, DOI 10.1007/s00380-018-1125-5
   Stanhope KL, 2009, J CLIN INVEST, V119, P1322, DOI 10.1172/JCI37385
   Su S, 2015, J DENT RES, V94, P403, DOI 10.1177/0022034514566215
   Suh JH, 2004, ARCH BIOCHEM BIOPHYS, V423, P126, DOI 10.1016/j.abb.2003.12.020
   Svensson RB, 2018, ACTA BIOMATER, V70, P270, DOI 10.1016/j.actbio.2018.02.005
   Tagliazucchi D, 2015, AMINO ACIDS, V47, P1077, DOI 10.1007/s00726-015-1951-z
   Takeuchi M, 2005, ALCOHOL CLIN EXP RES, V29, p220S, DOI 10.1097/01.alc.0000190657.97988.c7
   Takeuchi M, 2003, J NEUROPATH EXP NEUR, V62, P486, DOI 10.1093/jnen/62.5.486
   Tamanna N., 2015, INT J FOOD SCI, V2015
   Tan B, 2018, BIOCHEM BIOPH RES CO, V495, P78, DOI 10.1016/j.bbrc.2017.10.071
   Tesarova P, 2016, BIOMED PAP, V160, P1, DOI 10.5507/bp.2016.003
   Thomas CJ, 2018, BONE, V110, P128, DOI 10.1016/j.bone.2018.01.028
   THORNALLEY PJ, 1993, MOL ASPECTS MED, V14, P287, DOI 10.1016/0098-2997(93)90002-U
   Tóthová L, 2013, DIS MARKERS, V34, P9, DOI [10.1155/2013/591765, 10.3233/DMA-2012-00943]
   Uribarri J, 2003, J AM SOC NEPHROL, V14, P728, DOI 10.1097/01.ASN.0000051593.41395.B9
   Uribarri J, 2005, ANN NY ACAD SCI, V1043, P461, DOI 10.1196/annals.1333.052
   Uribarri J, 2015, ADV NUTR, V6, P461, DOI 10.3945/an.115.008433
   Uribarri J, 2010, J AM DIET ASSOC, V110, P911, DOI 10.1016/j.jada.2010.03.018
   van der Lugt T, 2018, NUTRIENTS, V10, DOI 10.3390/nu10121868
   Van Putte L., 2016, SCARS BURN HLTH, V2, P1
   VLASSARA H, 1988, SCIENCE, V240, P1546, DOI 10.1126/science.3259727
   Vlassara H, 2002, P NATL ACAD SCI USA, V99, P15596, DOI 10.1073/pnas.242407999
   Vlassopoulos A, 2014, P NUTR SOC, V73, P430, DOI 10.1017/S0029665114000603
   Wang DD, 2012, J NUTR, V142, P916, DOI 10.3945/jn.111.151951
   Wautier MP, 2017, DIABETES METAB SYND, V11, P305, DOI 10.1016/j.dsx.2016.09.009
   Wautier MP, 2004, THROMB HAEMOSTASIS, V91, P879, DOI 10.1160/TH03-07-0486
   Wei D, 2010, AUST DENT J, V55, P70, DOI 10.1111/j.1834-7819.2009.01123.x
   Wild S, 2004, DIABETES CARE, V27, P1047, DOI 10.2337/diacare.27.5.1047
   Xie JL, 2013, CELL SIGNAL, V25, P2185, DOI 10.1016/j.cellsig.2013.06.013
   Yamagishi SI, 2007, CURR DRUG TARGETS, V8, P1138, DOI 10.2174/138945007782151298
   Yoon MS, 2004, BIOCHEM BIOPH RES CO, V323, P377, DOI 10.1016/j.bbrc.2004.08.118
   Younis N, 2008, CURR OPIN LIPIDOL, V19, P378, DOI 10.1097/MOL.0b013e328306a057
   Yu MC, 2016, J PERIODONTOL, V87, P742, DOI 10.1902/jop.2016.150542
   Zhao DC, 2015, J BUON, V20, P614
NR 135
TC 19
Z9 20
U1 3
U2 40
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1752-0363
EI 1752-0371
J9 BIOMARK MED
JI Biomark. Med.
PD APR
PY 2019
VL 13
IS 6
BP 479
EP 495
DI 10.2217/bmm-2018-0448
PG 17
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA IM0TZ
UT WOS:000477703700007
PM 30968701
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Baskar, S
   Jhaveri, S
   Alkhouri, N
AF Baskar, Shankar
   Jhaveri, Simone
   Alkhouri, Naim
TI Cardiovascular risk in pediatric nonalcoholic fatty liver disease:
   recent advances
SO CLINICAL LIPIDOLOGY
LA English
DT Review
DE cardiovascular diseases; dyslipidemias; fatty liver; genetic;
   inflammation; insulin resistance; metabolic syndrome; nonalcoholic fatty
   liver disease; oxidative stress; pediatric obesity; polymorphism
ID INTIMA-MEDIA THICKNESS; CORONARY-HEART-DISEASE; 3RD NATIONAL-HEALTH;
   OBESE CHILDREN; INSULIN-RESISTANCE; METABOLIC SYNDROME; ARTERIAL
   STIFFNESS; CAROTID-ARTERY; UNITED-STATES; ADOLESCENTS
AB Nonalcoholic fatty liver disease (NAFLD) is the most common form of pediatric chronic liver disease in developed countries. NAFLD has risen to epidemic proportions paralleling that of childhood obesity. It is becoming increasingly evident that NAFLD is strongly linked with cardiovascular disease (CVD), which is the leading cause of mortality in the adult NAFLD population. It is very important for physicians caring for children being cognizant of the potential role of childhood NAFLD as an independent risk factor for CVD. Childhood is a time period where subclinical CVD can be detected, giving us the potential ability to halt or reverse the disease process. In this review, we discuss recent evidence linking childhood NAFLD to CVD and potential pathogenic links.
C1 [Baskar, Shankar; Jhaveri, Simone] Childrens Hosp, Cleveland Clin, Dept Pediat, Cleveland, OH 44195 USA.
   [Alkhouri, Naim] Childrens Hosp, Cleveland Clin, Dept Pediat Gastroenterol, Cleveland, OH 44195 USA.
   [Alkhouri, Naim] Cleveland Clin, Digest Dis Inst, Cleveland, OH 44106 USA.
C3 Cleveland Clinic Foundation; Cleveland Clinic Foundation; Cleveland
   Clinic Foundation
RP Alkhouri, N (corresponding author), Childrens Hosp, Cleveland Clin, Dept Pediat Gastroenterol, 9500 Euclid Ave,A111, Cleveland, OH 44195 USA.
EM alkhoun@ccf.org
CR Akin L, 2013, ACTA PAEDIATR, V102, pe107, DOI 10.1111/apa.12099
   Alkhouri N, 2010, DIGEST DIS SCI, V55, P2644, DOI 10.1007/s10620-009-1075-y
   Alp H, 2013, CAN J CARDIOL, V29, P1118, DOI 10.1016/j.cjca.2012.07.846
   ANDERSON TJ, 1995, J AM COLL CARDIOL, V26, P1235, DOI 10.1016/0735-1097(95)00327-4
   Ballestri S, 2014, WORLD J GASTROENTERO, V20, P1724, DOI 10.3748/wjg.v20.i7.1724
   BERENSON GS, 1992, AM J CARDIOL, V70, P851, DOI 10.1016/0002-9149(92)90726-F
   BERLINER JA, 1995, CIRCULATION, V91, P2488, DOI 10.1161/01.CIR.91.9.2488
   Bornfeldt KE, 2011, CELL METAB, V14, P575, DOI 10.1016/j.cmet.2011.07.015
   Caserta CA, 2010, AM J EPIDEMIOL, V171, P1195, DOI 10.1093/aje/kwq073
   Cook S, 2003, ARCH PEDIAT ADOL MED, V157, P821, DOI 10.1001/archpedi.157.8.821
   de Ferranti SD, 2004, CIRCULATION, V110, P2494, DOI 10.1161/01.CIR.0000145117.40114.C7
   de Groot E, 2004, CIRCULATION, V109, P33, DOI 10.1161/01.CIR.0000131516.65699.ba
   Demircioglu F, 2008, J PEDIATR GASTR NUTR, V47, P68, DOI 10.1097/MPG.0b013e31816232c9
   Feldstein AE, 2009, GUT, V58, P1538, DOI 10.1136/gut.2008.171280
   Fintini D, 2014, NUTR METAB CARDIOVAS, V24, P72, DOI 10.1016/j.numecd.2013.06.005
   Fitzgibbons TP, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.113.000582
   Friend A, 2013, METAB SYNDR RELAT D, V11, P71, DOI 10.1089/met.2012.0122
   Gökçe S, 2013, PEDIATR CARDIOL, V34, P308, DOI 10.1007/s00246-012-0447-9
   Griffin JL, 2015, CIRC-CARDIOVASC GENE, V8, P187, DOI 10.1161/CIRCGENETICS.114.000219
   Huang RC, 2013, HEPATOLOGY, V58, P1306, DOI 10.1002/hep.26495
   Huang XD, 2008, WORLD J GASTROENTERO, V14, P2888, DOI 10.3748/wjg.14.2888
   Hui JM, 2004, HEPATOLOGY, V40, P46, DOI 10.1002/hep.20280
   Kelishadi R, 2009, ATHEROSCLEROSIS, V204, P538, DOI 10.1016/j.atherosclerosis.2008.09.034
   Kelly AS, 2013, CIRCULATION, V128, P1689, DOI 10.1161/CIR.0b013e3182a5cfb3
   Kozlitina J, 2014, NAT GENET, V46, P352, DOI 10.1038/ng.2901
   Laurent S, 2006, EUR HEART J, V27, P2588, DOI 10.1093/eurheartj/ehl254
   Lawlor DA, 2014, J CLIN ENDOCR METAB, V99, pEe410
   Linder K, 2014, OBESITY, V22, P1325, DOI 10.1002/oby.20685
   Liu YL, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms5309
   Lonardo A, 2015, DIGEST LIVER DIS, V47, P181, DOI 10.1016/j.dld.2014.09.020
   Manco M, 2008, INT J OBESITY, V32, P381, DOI 10.1038/sj.ijo.0803711
   Manco M, 2010, ATHEROSCLEROSIS, V209, P463, DOI 10.1016/j.atherosclerosis.2009.10.014
   Mattace-Raso FUS, 2006, CIRCULATION, V113, P657, DOI 10.1161/CIRCULATIONAHA.105.555235
   McGill HC, 2000, ARTERIOSCL THROM VAS, V20, P836, DOI 10.1161/01.ATV.20.3.836
   Nascimbeni F, 2013, J HEPATOL, V59, P859, DOI 10.1016/j.jhep.2013.05.044
   Nicholson JK, 2012, SCIENCE, V336, P1262, DOI 10.1126/science.1223813
   Nigro J, 2006, ENDOCR REV, V27, P242, DOI 10.1210/er.2005-0007
   Nobili V, 2015, JAMA PEDIATR, V169, P170, DOI 10.1001/jamapediatrics.2014.2702
   Nobili V, 2010, PEDIATR RES, V67, P665, DOI 10.1203/PDR.0b013e3181da4798
   Ogden CL, 2014, JAMA-J AM MED ASSOC, V311, P806, DOI 10.1001/jama.2014.732
   Pacifico L, 2014, NUTR METAB CARDIOVAS, V24, P737, DOI 10.1016/j.numecd.2014.01.010
   Pacifico L, 2008, PEDIATR RES, V63, P423, DOI 10.1203/PDR.0b013e318165b8e7
   Pacifico L, 2014, HEPATOLOGY, V59, P461, DOI 10.1002/hep.26610
   Pacifico L, 2010, HEPATOLOGY, V52, P1643, DOI 10.1002/hep.23890
   Paré G, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1001374
   Patton HM, 2006, J PEDIATR GASTR NUTR, V43, P413, DOI 10.1097/01.mpg.0000239995.58388.56
   Petta S, 2015, J HEPATOL, V62, P928, DOI 10.1016/j.jhep.2014.11.030
   Petta S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0074089
   Pischon T, 2004, JAMA-J AM MED ASSOC, V291, P1730, DOI 10.1001/jama.291.14.1730
   Rask-Madsen C, 2010, CELL METAB, V11, P379, DOI 10.1016/j.cmet.2010.03.013
   Rittig K, 2009, ATHEROSCLEROSIS, V207, P341, DOI 10.1016/j.atherosclerosis.2009.05.018
   Schwimmer JB, 2005, PEDIATRICS, V115, pE561, DOI 10.1542/peds.2004-1832
   Schwimmer JB, 2006, PEDIATRICS, V118, P1388, DOI 10.1542/peds.2006-1212
   Schwimmer JB, 2008, CIRCULATION, V118, P277, DOI 10.1161/CIRCULATIONAHA.107.739920
   Sert A, 2013, J CLIN RES PEDIATR E, V5, P182, DOI 10.4274/Jcrpe.891
   Sert A, 2013, AM J CARDIOL, V112, P436, DOI 10.1016/j.amjcard.2013.03.056
   Sert A, 2012, J PEDIATR ENDOCR MET, V25, P927, DOI 10.1515/jpem-2012-0187
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Singh GK, 2013, J PEDIATR-US, V162, P1160, DOI 10.1016/j.jpeds.2012.11.024
   Skinner AC, 2014, JAMA PEDIATR, V168, P561, DOI 10.1001/jamapediatrics.2014.21
   Targher G, 2007, DIABETES CARE, V30, P1212, DOI 10.2337/dc06-2247
   Targher G, 2013, SEMIN THROMB HEMOST, V39, P214, DOI 10.1055/s-0033-1334866
   Targher G, 2010, NEW ENGL J MED, V363, P1341, DOI 10.1056/NEJMra0912063
   Than NN, 2015, ATHEROSCLEROSIS, V239, P192, DOI 10.1016/j.atherosclerosis.2015.01.001
   Vajro P, 2012, J PEDIATR GASTR NUTR, V54, P700, DOI 10.1097/MPG.0b013e318252a13f
   Valenti L, 2010, HEPATOLOGY, V51, P1209, DOI 10.1002/hep.23622
   Van Vré EA, 2012, ARTERIOSCL THROM VAS, V32, P887, DOI 10.1161/ATVBAHA.111.224873
   Vassilopoulos D, 2012, INT J CARDIOL, V160, P66, DOI 10.1016/j.ijcard.2012.05.086
   Verrijken A, 2014, HEPATOLOGY, V59, P121, DOI 10.1002/hep.26510
   Wallace AM, 2001, CIRCULATION, V104, P3052, DOI 10.1161/hc5001.101061
   Weghuber D, 2011, INT J PEDIATR OBES, V6, P120, DOI 10.3109/17477161003792580
   Weiss R, 2004, NEW ENGL J MED, V350, P2362, DOI 10.1056/NEJMoa031049
   Wong VWS, 2011, GUT, V60, P1721, DOI 10.1136/gut.2011.242016
   Xu AM, 2003, J CLIN INVEST, V112, P91, DOI 10.1172/JCI200317797
   Yoneda M, 2007, J GASTROENTEROL, V42, P573, DOI 10.1007/s00535-007-2060-x
NR 75
TC 2
Z9 2
U1 0
U2 3
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1758-4299
EI 1758-4302
J9 CLIN LIPIDOL
JI Clin. Lipidol.
PY 2015
VL 10
IS 4
BP 351
EP 362
DI 10.2217/clp.15.26
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CP7WF
UT WOS:000360099100008
DA 2025-06-11
ER

PT J
AU Katsarou, A
   Triposkiadis, F
   Skoularigis, J
   Papageorgiou, C
   Panagiotakos, DB
AF Katsarou, A.
   Triposkiadis, F.
   Skoularigis, J.
   Papageorgiou, C.
   Panagiotakos, D. B.
TI Evaluating the role of Mediterranean diet and eating behaviors on the
   likelihood of having a non-fatal acute coronary syndrome, under the
   context of stress perception: a case-control study
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID CARDIOVASCULAR-DISEASE RISK; PERCEIVED STRESS; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; GLOBAL MEASURE; HEART-DISEASE; PREVENTION;
   DEPRESSION; HEALTH; METAANALYSIS
AB BACKGROUND/OBJECTIVES: Mediterranean diet and perceived stress have long been associated with the likelihood of having an acute coronary syndrome (ACS). The aim of this study was to evaluate whether the Mediterranean diet and other eating behaviors mediate and/or moderate the unfavorable impact of perceived stress on the likelihood of having a non-fatal ACS.
   SUBJECTS/METHODS: This is a case control study with individuals matched by age and sex. A total of 250 consecutive patients (60 +/- 11 years, 78% men) with a first ACS and 250 population-based, control subjects (60 +/- 8.6 years, 77.6% men) were enrolled. Perceived stress levels were evaluated with the Perceived Stress Scale (PSS-14; range 0-14), and adherence to the Mediterranean diet was assessed by the MedDietScore (range 0-55). Stress eating, eating heavy meals and eating alone were also evaluated.
   RESULTS: For each unit increase in the P55-14, the likelihood of having an ACS increased by 14% (95% confidence interval (CI) = 1.10, 1.18). Stratified analysis by Mediterranean diet adherence level revealed a similar association of PSS-14 with ACS likelihood between the low-to-moderate and moderate-to-high adherence groups (that is, odds ratio (OR) = 1.15, 95% CI = 1.09, 1.21 and OR = 1.13, 95% CI = 1.07, 1.80, respectively). Stress eating and eating alone were positively associated with the likelihood of having an ACS (OR = 1.31, 95% CI = 0.97, 1.77 and OR = 1.36, 95% CI = 1.08, 1.69, respectively). Eating heavy meals was not associated with ACS (OR = 1.08, 95% CI = 0.82, 1.41); no mediating or moderating effect of these behaviors on perceived stress ACS was observed.
   CONCLUSIONS: The highly significant impact of perceived stress On ACS likelihood was not mediated or moderated by the level of adherence to the Mediterranean diet or other eating behaviors, underlying the strong effect of this psychological disorder on ACS.
C1 [Katsarou, A.; Triposkiadis, F.; Skoularigis, J.] Univ Thessaly, Sch Med, Dept Cardiol, Larisa, Greece.
   [Papageorgiou, C.] Univ Athens, Eginit Hosp, Sch Med, Dept Psychiat 1, GR-11528 Athens, Greece.
   [Panagiotakos, D. B.] Univ Athens, Dept Nutr & Dietet, Athens, Greece.
C3 University of Thessaly; Athens Medical School; National & Kapodistrian
   University of Athens; National & Kapodistrian University of Athens
RP Panagiotakos, DB (corresponding author), Harokopio Univ, Dept Nutr & Dietet, 46 Paleon Polemiston St, Athens 16674, Greece.
EM d.b.panagiotakos@usa.net
RI Panagiotakos, Demosthenes/K-8294-2019
OI Papageorgiou, Charalabos/0000-0001-7635-1956; skoularigis,
   john/0000-0001-7159-2478
CR Anagnostis P, 2009, J CLIN ENDOCR METAB, V94, P2692, DOI 10.1210/jc.2009-0370
   Andreou E, 2011, INT J ENV RES PUB HE, V8, P3287, DOI 10.3390/ijerph8083287
   Antonogeorgos G, 2012, ANN EPIDEMIOL, V22, P630, DOI 10.1016/j.annepidem.2012.06.103
   BARON RM, 1986, J PERS SOC PSYCHOL, V51, P1173, DOI 10.1037/0022-3514.51.6.1173
   Bountziouka V, 2012, NUTR METAB CARDIOVAS, V22, P659, DOI 10.1016/j.numecd.2010.10.015
   Chandola T, 2008, EUR HEART J, V29, P640, DOI 10.1093/eurheartj/ehm584
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Cohen S, 2007, JAMA-J AM MED ASSOC, V298, P1685, DOI 10.1001/jama.298.14.1685
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   Daubenmier J, 2011, J OBES, V2011, DOI 10.1155/2011/651936
   Eaker ED, 2007, PSYCHOSOM MED, V69, P509, DOI 10.1097/PSY.0b013e3180f62357
   Epel E, 2004, ANN NY ACAD SCI, V1032, P208, DOI 10.1196/annals.1314.022
   Ford PA, 2013, J PSYCHOSOM RES, V74, P142, DOI 10.1016/j.jpsychores.2012.11.002
   Groesz LM, 2012, APPETITE, V58, P717, DOI 10.1016/j.appet.2011.11.028
   Grossniklaus DA, 2010, J CARDIOVASC NURS, V25, P450, DOI 10.1097/JCN.0b013e3181d25433
   Harrington J, 2010, EUR J PUBLIC HEALTH, V20, P91, DOI 10.1093/eurpub/ckp102
   Hu FB, 2002, JAMA-J AM MED ASSOC, V288, P2569, DOI 10.1001/jama.288.20.2569
   Kastorini CM, 2013, NUTR METAB CARDIOVAS, V23, P242, DOI 10.1016/j.numecd.2011.12.013
   Kastorini CM, 2011, CARDIOL RES PRACT, V2011, DOI 10.4061/2011/313948
   Kastorini CM, 2011, J AM COLL CARDIOL, V57, P1299, DOI 10.1016/j.jacc.2010.09.073
   Katsarou A, 2012, CENT EUR J PUBL HEAL, V20, P104, DOI 10.21101/cejph.a3698
   Katsarou AL, 2013, ANGIOLOGY, V64, P529, DOI 10.1177/0003319712458963
   Kuriyama S, 2010, CIRC J, V74, P248, DOI 10.1253/circj.CJ-09-1004
   Lands WEM, 2003, NUTR METAB CARDIOVAS, V13, P154, DOI 10.1016/S0939-4753(03)80175-8
   Laugero KD, 2011, APPETITE, V56, P194, DOI 10.1016/j.appet.2010.11.001
   Lohse B, 2010, J NUTR, V140, P1322, DOI 10.3945/jn.109.120188
   Matsumura Kenta, 2012, BMC Res Notes, V5, P288, DOI 10.1186/1756-0500-5-288
   O'Connor DB, 2004, STRESS HEALTH, V20, P279, DOI 10.1002/smi.1028
   Öhlin B, 2004, EUR HEART J, V25, P867, DOI 10.1016/j.ehj.2004.03.003
   Panagiotakos D B, 2002, Cent Eur J Public Health, V10, P11
   Panagiotakos DB, 2006, NUTR METAB CARDIOVAS, V16, P559, DOI 10.1016/j.numecd.2005.08.006
   Papathanasiou George, 2009, Hellenic J Cardiol, V50, P283
   Richardson S, 2012, AM J CARDIOL, V110, P1711, DOI 10.1016/j.amjcard.2012.08.004
   Rod NH, 2009, J INTERN MED, V266, P467, DOI 10.1111/j.1365-2796.2009.02124.x
   Rosmond R, 1998, J CLIN ENDOCR METAB, V83, P1853, DOI 10.1210/jc.83.6.1853
   Rumsfeld JS, 2005, CIRCULATION, V111, P250, DOI 10.1161/01.CIR.0000154573.62822.89
   Sauder KA, 2012, PSYCHOPHYSIOLOGY, V49, P470, DOI 10.1111/j.1469-8986.2011.01335.x
   Sergey CM, 2010, OPEN NUTRACEUTICALS, V3, P166
   Sofi F, 2008, BMJ-BRIT MED J, V337, DOI 10.1136/bmj.a1344
   Steptoe A, 2009, NEUROSCI BIOBEHAV R, V33, P63, DOI 10.1016/j.neubiorev.2008.04.010
   Thygesen K, 2007, CIRCULATION, V116, P2634, DOI [10.1161/CIRCULATIONAHA.107.187397, 10.1016/j.jacc.2007.09.011]
   von Känel R, 2012, SWISS MED WKLY, V142, DOI 10.4414/smw.2012.13502
   Medina FX, 2009, PUBLIC HEALTH NUTR, V12, P1618, DOI 10.1017/S1368980009990450
NR 44
TC 3
Z9 4
U1 0
U2 13
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0954-3007
EI 1476-5640
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD SEP
PY 2014
VL 68
IS 9
BP 1016
EP 1021
DI 10.1038/ejcn.2014.74
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA AO2PV
UT WOS:000341168600007
PM 24781691
OA Bronze
DA 2025-06-11
ER

PT J
AU Tarantino, G
   Citro, V
   Finelli, C
AF Tarantino, Giovanni
   Citro, Vincenzo
   Finelli, Carmine
TI What Non-Alcoholic Fatty Liver Disease Has Got to Do with Obstructive
   Sleep Apnoea Syndrome and viceversa?
SO JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES
LA English
DT Review
DE non-alcoholic fatty liver disease (NAFLD); obstructive sleep apnoea
   syndrome (OSAS); body mass index (BMI)
ID POSITIVE AIRWAY PRESSURE; C-REACTIVE PROTEIN; CHRONIC INTERMITTENT
   HYPOXIA; NF-KAPPA-B; INSULIN-RESISTANCE; OXIDATIVE STRESS; ENDOTHELIAL
   DYSFUNCTION; METABOLIC SYNDROME; HEPATIC STEATOSIS; OBESE SUBJECTS
AB Non-alcoholic fatty liver disease (NAFLD) and obstructive sleep apnoea syndrome (OSAS) are common conditions, frequently encountered in patients with obesity and/or metabolic syndrome. NAFLD and OSAS are complex diseases that involve an interaction of several intertwined factors. Several lines of evidence lend credence to an immune system derangement in these patients, i.e. the low grade chronic inflammation status, reckoned to be the most important factor in causing and maintaining these two illnesses. Furthermore, it is emphasized the main role of spleen involvement, as a novel mechanism. In this review the contribution of the visceral adiposity in both NAFLD and OSAS is stressed as well as the role of intermittent hypoxia. Finally, a post on the prevention of systemic inflammation is made.
C1 [Tarantino, Giovanni] Univ Naples Federico II, Med Sch Naples, Dept Clin Med & Surg, Naples, Italy.
   [Tarantino, Giovanni] INT Fdn Pascale Canc Res Ctr Mercogliano, Mercogliano, AV, Italy.
   [Citro, Vincenzo] Umberto I Hosp, Dept Internal Med, Salerno, Italy.
   [Finelli, Carmine] Stella Maris Mediterraneum Fdn, Ctr Obes & Eating Disorders, Potenza, Italy.
C3 University of Naples Federico II; IRCCS Fondazione Stella Maris
RP Tarantino, G (corresponding author), Federico II Univ Med Sch Naples, Dept Clin Med & Surg, Naples, Italy.
EM tarantin@unina.it
RI Tarantino, Giovanni/AAW-2007-2021
CR Al Ghobain M, 2012, BMC PULM MED, V12, DOI [10.1186/1471-2466-12-10, 10.1186/1471-2458-12-239]
   Arnardottir ES, 2012, SLEEP, V35, P921, DOI 10.5665/sleep.1952
   Aron-Wisnewsky J, 2012, J HEPATOL, V56, P225, DOI 10.1016/j.jhep.2011.04.022
   Ascensao A, 2012, MITOCHONDRION, V12, P607, DOI 10.1016/j.mito.2012.10.007
   Barbato A, 2009, INTERN EMERG MED, V4, P315, DOI 10.1007/s11739-009-0240-9
   Blaak EE, 2003, P NUTR SOC, V62, P753, DOI 10.1079/PNS2003290
   Braunersreuther V, 2012, WORLD J GASTROENTERO, V18, P727, DOI 10.3748/wjg.v18.i8.727
   Broström A, 2012, SCAND J PRIM HEALTH, V30, P107, DOI 10.3109/02813432.2012.675563
   Busetto L, 2005, DIABETES OBES METAB, V7, P301, DOI 10.1111/j.1463-1326.2004.00391.x
   Cai DS, 2004, CELL, V119, P285, DOI 10.1016/j.cell.2004.09.027
   Cai DS, 2005, NAT MED, V11, P183, DOI 10.1038/nm1166
   CHAPLEAU MW, 1995, CLIN EXP HYPERTENS, V17, P1, DOI 10.3109/10641969509087050
   Choukèr A, 2012, TRANSPLANTATION, V94, P894, DOI 10.1097/TP.0b013e31826a9a46
   Ciftci TU, 2004, CYTOKINE, V28, P87, DOI 10.1016/j.cyto.2004.07.003
   da Rosa DP, 2012, MEDIAT INFLAMM, V2012, DOI 10.1155/2012/879419
   Del Ben M, 2012, BMC PULM MED, V12, DOI 10.1186/1471-2466-12-36
   Devulapally K, 2009, HEART FAIL REV, V14, P155, DOI 10.1007/s10741-008-9101-2
   Dorkova Z, 2008, CHEST, V134, P686, DOI 10.1378/chest.08-0556
   Drager LF, 2011, OBESITY, V19, P2167, DOI 10.1038/oby.2011.240
   Dyugovskaya L, 2005, EUR RESPIR J, V25, P820, DOI 10.1183/09031936.05.00103204
   Dyugovskaya L, 2011, AM J RESP CELL MOL, V45, P154, DOI 10.1165/rcmb.2010-0025OC
   El-Koofy NM, 2012, SAUDI J GASTROENTERO, V18, P44, DOI 10.4103/1319-3767.91738
   Farney RJ, 2011, J CLIN SLEEP MED, V7, P459, DOI 10.5664/JCSM.1306
   Farrell GC, 2012, GUT LIVER, V6, P149, DOI 10.5009/gnl.2012.6.2.149
   Finelli C, 2013, WORLD J GASTROENTERO, V19, P802, DOI 10.3748/wjg.v19.i6.802
   Finelli C, 2012, J GASTROINTEST LIVER, V21, P293
   Finelli C, 2012, J GASTROINTEST LIVER, V21, P207
   Fiorenza CG, 2011, NAT REV ENDOCRINOL, V7, P137, DOI 10.1038/nrendo.2010.199
   Foster MT, 2010, PHYSIOL BEHAV, V101, P282, DOI 10.1016/j.physbeh.2010.05.014
   Fukushima J, 2009, HEPATOL RES, V39, P724, DOI 10.1111/j.1872-034X.2009.00509.x
   Garcia JM, 2011, RESP RES, V12, DOI 10.1186/1465-9921-12-80
   Garg R, 2012, ANN THORAC MED, V7, P26, DOI 10.4103/1817-1737.91561
   Guven SF, 2012, SLEEP BREATH, V16, P217, DOI 10.1007/s11325-011-0492-2
   Hamaguchi M, 2012, WORLD J GASTROENTERO, V18, P156, DOI 10.3748/wjg.v18.i2.156
   Harsch IA, 2004, AM J RESP CRIT CARE, V169, P156, DOI 10.1164/rccm.200302-206OC
   Ho ML, 2011, NEUROL INT, V3, P60, DOI 10.4081/ni.2011.e15
   HOFFSTEIN V, 1992, EUR RESPIR J, V5, P377
   Huffman DM, 2009, BBA-GEN SUBJECTS, V1790, P1117, DOI 10.1016/j.bbagen.2009.01.008
   Hundal RS, 2002, J CLIN INVEST, V109, P1321, DOI 10.1172/JCI200214955
   IKEN K, 1995, CELL IMMUNOL, V163, P1, DOI 10.1006/cimm.1995.1092
   Inancli HM, 2010, RECENT PATENTS INFLA, V4, P54, DOI 10.2174/187221310789895568
   Ip MSM, 2002, AM J RESP CRIT CARE, V165, P670, DOI 10.1164/ajrccm.165.5.2103001
   Itzhaki S, 2005, SLEEP, V28, P594, DOI 10.1093/sleep/28.5.594
   Jun JC, 2012, AM J PHYSIOL-ENDOC M, V303, pE377, DOI 10.1152/ajpendo.00641.2011
   Karin M, 2000, ANNU REV IMMUNOL, V18, P621, DOI 10.1146/annurev.immunol.18.1.621
   Kent BD, 2011, RESP PHYSIOL NEUROBI, V178, P475, DOI 10.1016/j.resp.2011.03.015
   Klover PJ, 2003, DIABETES, V52, P2784, DOI 10.2337/diabetes.52.11.2784
   Kukla M, 2011, MOL MED, V17, P1397, DOI 10.2119/molmed.2010.00105
   Lavie L, 2009, PROG CARDIOVASC DIS, V51, P303, DOI 10.1016/j.pcad.2008.08.003
   Lee UE, 2011, BEST PRACT RES CL GA, V25, P195, DOI 10.1016/j.bpg.2011.02.005
   Liu ZQ, 2012, DIABETES METAB J, V36, P83, DOI 10.4093/dmj.2012.36.2.83
   Lubrano C, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047059
   Lui MMS, 2012, J THORAC DIS, V4, P164, DOI 10.3978/j.issn.2072-1439.2012.01.06
   Mandal P, 2010, HEPATOLOGY, V51, P1420, DOI 10.1002/hep.23427
   Matsuzawa Y, 2010, CURR PHARM DESIGN, V16, P1896, DOI 10.2174/138161210791208893
   Mehra R, 2006, ARCH INTERN MED, V166, P1725, DOI 10.1001/archinte.166.16.1725
   Mirrakhimov Aibek E, 2012, Front Neurol, V3, P149, DOI 10.3389/fneur.2012.00149
   Murugan A T, 2008, Chron Respir Dis, V5, P233, DOI 10.1177/1479972308096978
   Musso G, 2013, OBES REV, V14, P417, DOI 10.1111/obr.12020
   Nagarajan P, 2012, WORLD J GASTROENTERO, V18, P1141, DOI 10.3748/wjg.v18.i11.1141
   Norman D, 2008, SLEEP, V31, P121, DOI 10.1093/sleep/31.1.121
   Ohga E, 2003, J APPL PHYSIOL, V94, P179, DOI 10.1152/japplphysiol.00177.2002
   Öhman MK, 2008, CIRCULATION, V117, P798, DOI 10.1161/CIRCULATIONAHA.107.717595
   Park JG, 2011, MAYO CLIN PROC, V86, P549, DOI 10.4065/mcp.2010.0810
   Peppard PE, 2000, NEW ENGL J MED, V342, P1378, DOI 10.1056/NEJM200005113421901
   Polyzos SA, 2011, METABOLISM, V60, P313, DOI 10.1016/j.metabol.2010.09.003
   Prabhakar NR, 2010, RESP PHYSIOL NEUROBI, V174, P156, DOI 10.1016/j.resp.2010.08.021
   Punjabi NM, 2004, AM J EPIDEMIOL, V160, P521, DOI 10.1093/aje/kwh261
   Ramesh V, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-91
   Reaven GM, 1996, NEW ENGL J MED, V334, P374, DOI 10.1056/NEJM199602083340607
   Rector RS, 2010, J HEPATOL, V52, P727, DOI 10.1016/j.jhep.2009.11.030
   Rogers CQ, 2008, IUBMB LIFE, V60, P790, DOI 10.1002/iub.124
   Romero-Corral A, 2010, CHEST, V137, P711, DOI 10.1378/chest.09-0360
   Ryan S, 2005, CIRCULATION, V112, P2660, DOI 10.1161/CIRCULATIONAHA.105.556746
   Sabanayagam C, 2012, INT J ENDOCRINOL, V2012, DOI 10.1155/2012/879134
   Sarkar K, 2012, P NATL ACAD SCI USA, V109, P10504, DOI 10.1073/pnas.1208314109
   Savastano S, 2011, J TRANSL MED, V9, DOI 10.1186/1479-5876-9-136
   Schulz R, 2000, AM J RESP CRIT CARE, V162, P566, DOI 10.1164/ajrccm.162.2.9908091
   Seidell JC, 2010, EUR J CLIN NUTR, V64, P35, DOI 10.1038/ejcn.2009.71
   Simiakakis M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039172
   Soneja M, 2012, LUNG INDIA, V29, P107, DOI 10.4103/0970-2113.95298
   Stadler DL, 2009, SLEEP, V32, P1579, DOI 10.1093/sleep/32.12.1579
   Stefulj J, 2000, BRAIN BEHAV IMMUN, V14, P219, DOI 10.1006/brbi.1999.0579
   Stepniakowski KT, 1996, AM J PHYSIOL-REG I, V270, pR1340, DOI 10.1152/ajpregu.1996.270.6.R1340
   Stradling JR, 2001, THORAX, V56, P45
   Tabit CE, 2010, REV ENDOCR METAB DIS, V11, P61, DOI 10.1007/s11154-010-9134-4
   Tamura Y, 2010, J ATHEROSCLER THROMB, V17, P219, DOI 10.5551/jat.3368
   Tarantino G, 2011, J BIOL REG HOMEOS AG, V25, P47
   Tarantino G, 2011, WORLD J GASTROENTERO, V17, P5280, DOI 10.3748/wjg.v17.i48.5280
   Tarantino G, 2011, WORLD J GASTROENTERO, V17, P3776, DOI 10.3748/wjg.v17.i33.3776
   Tarantino G, 2009, J INFLAMM-LOND, V6, DOI 10.1186/1476-9255-6-6
   Taylor CT, 2009, ANN NY ACAD SCI, V1177, P178, DOI 10.1111/j.1749-6632.2009.05024.x
   Türkay C, 2012, RESP CARE, V57, P244, DOI 10.4187/respcare.01184
   Van Wagner Lisa B, 2011, Therap Adv Gastroenterol, V4, P249, DOI 10.1177/1756283X11403809
   Vgontzas Alexandros N., 2008, Archives of Physiology and Biochemistry, V114, P211, DOI [10.1080/13813450802364627, 10.1080/13813450802364627 ]
   Vgontzas AN, 2005, SLEEP MED REV, V9, P211, DOI 10.1016/j.smrv.2005.01.006
   Völzke H, 2012, WORLD J GASTROENTERO, V18, P3492, DOI 10.3748/wjg.v18.i27.3492
   Wang H, 2013, SLEEP BREATH, V17, P957, DOI 10.1007/s11325-012-0784-1
   Wang Y, 2009, ARQ BRAS ENDOCRINOL, V53, P201, DOI 10.1590/S0004-27302009000200012
   Wiener RC, 2012, INT J VASC MED, V2012, DOI 10.1155/2012/914593
   Wilson PWF, 2003, CIRCULATION, V108, P1537, DOI 10.1161/01.CIR.0000089506.12223.F1
   Yokoe T, 2003, CIRCULATION, V107, P1129, DOI 10.1161/01.CIR.0000052627.99976.18
   Zinman B, 1999, J CLIN ENDOCR METAB, V84, P272, DOI 10.1210/jc.84.1.272
NR 103
TC 5
Z9 8
U1 0
U2 8
PU MEDICAL UNIV PRESS
PI CLUJ-NAPOCA
PA 3RD MEDICAL CLINIC, STR CROITORILOR NO 19-21, CLUJ-NAPOCA, 400162,
   ROMANIA
SN 1841-8724
EI 1842-1121
J9 J GASTROINTEST LIVER
JI J. Gastrointest. Liver Dis.
PD SEP
PY 2014
VL 23
IS 3
BP 291
EP 299
DI 10.1543/jgld.2014.1121.233.gvt
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AP9IT
UT WOS:000342394200014
PM 25267958
DA 2025-06-11
ER

PT J
AU Bernardes, N
   Dias, DD
   Stoyell-Conti, FF
   Brito-Monzani, JD
   Malfitano, C
   Caldini, EG
   Ulloa, L
   Llesuy, SF
   Irigoyen, MC
   De Angelis, K
AF Bernardes, Nathalia
   Dias, Danielle da Silva
   Stoyell-Conti, Filipe Fernandes
   Brito-Monzani, Janaina de Oliveira
   Malfitano, Christiane
   Caldini, Elia Garcia
   Ulloa, Luis
   Llesuy, Susana Francisca
   Irigoyen, Maria-Claudia
   De Angelis, Katia
TI Baroreflex Impairment Precedes Cardiometabolic Dysfunction in an
   Experimental Model of Metabolic Syndrome: Role of Inflammation and
   Oxidative Stress
SO SCIENTIFIC REPORTS
LA English
DT Article
ID INSULIN-RESISTANCE; HEART-RATE; FRUCTOSE; SENSITIVITY; HYPERTENSION;
   RISK; MECHANISMS; MORTALITY; OBESITY; CELLS
AB This study analyzes whether autonomic dysfunction precedes cardiometabolic alterations in spontaneously hypertensive rats (SHR) with fructose overload. Animals were randomly distributed into three groups: control, hypertensive and hypertensive with fructose overload. Fructose overload (100 g/L) was initiated at 30 days old, and the animals (n = 6/group/time) were evaluated after 7,15, 30 and 60 days of fructose consumption. Fructose consumption reduced baroreflex sensitivity by day 7, and still induced a progressive reduction in baroreflex sensitivity over the time. Fructose consumption also increased TNF alpha and IL-6 levels in the adipose tissue and IL-1 beta(3 levels in the spleen at days 15 and 30. Fructose consumption also reduced plasmatic nitrites (day 15 and 30) and superoxide dismutase activity (day 15 and 60), but increased hydrogen peroxide (day 30 and 60), lipid peroxidation and protein oxidation (day 60). Fructose consumption increased arterial pressure at day 30 (8%) and 60 (11%). Fructose consumption also induced a late insulin resistance at day 60, but did not affect glucose levels. In conclusion, the results show that baroreflex sensitivity impairment precedes inflammatory and oxidative stress disorders, probably by inducing hemodynamic and metabolic dysfunctions observed in metabolic syndrome.
C1 [Bernardes, Nathalia; Dias, Danielle da Silva; Stoyell-Conti, Filipe Fernandes; Brito-Monzani, Janaina de Oliveira; Malfitano, Christiane; De Angelis, Katia] Univ Nove Julho UNINOVE, Lab Translat Physiol, Sao Paulo, SP, Brazil.
   [Bernardes, Nathalia] Cidade Sao Paulo Univ UNICID, Lab Physiol & Metab, Sao Paulo, SP, Brazil.
   [Brito-Monzani, Janaina de Oliveira] Univ Fed Maranhao, Sao Luis, MA, Brazil.
   [Malfitano, Christiane] Fed Univ Lavras UFLA, Dept Hlth Sci, Lavras, MG, Brazil.
   [Bernardes, Nathalia; Caldini, Elia Garcia; Irigoyen, Maria-Claudia; De Angelis, Katia] Univ Sao Paulo, Heart Inst InCor, Hypertens Unit, Sao Paulo, SP, Brazil.
   [Ulloa, Luis] Rutgers State Univ, Rutgers New Jersey Med Sch, Ctr Immunol & Inflammat, Dept Surg, Newark, NJ USA.
   [Llesuy, Susana Francisca] Univ Buenos Aires, Dept Gen & Inorgan Chem, Buenos Aires, DF, Argentina.
   [De Angelis, Katia] Fed Univ Sao Paulo UNIFESP, Dept Physiol, Sao Paulo, SP, Brazil.
C3 Universidade Nove de Julho; Universidade Federal do Maranhao;
   Universidade Federal de Lavras; Universidade de Sao Paulo; Rutgers
   University System; Rutgers University Newark; Rutgers University New
   Brunswick; Rutgers University Biomedical & Health Sciences; University
   of Buenos Aires; Universidade Federal de Sao Paulo (UNIFESP)
RP De Angelis, K (corresponding author), Univ Nove Julho UNINOVE, Lab Translat Physiol, Sao Paulo, SP, Brazil.; De Angelis, K (corresponding author), Univ Sao Paulo, Heart Inst InCor, Hypertens Unit, Sao Paulo, SP, Brazil.; De Angelis, K (corresponding author), Fed Univ Sao Paulo UNIFESP, Dept Physiol, Sao Paulo, SP, Brazil.
EM prof.kangelis@yahoo.com.br
RI Bernardes, Nathalia/L-7460-2015; Malfitano, Christiane/I-2701-2013;
   Ulloa, Luis/AAE-8751-2019; da Silva Dias, Danielle/AAN-7618-2020;
   Irigoyen, maria Claudia/N-6880-2014; Caldini, Elia Garcia/F-1105-2011;
   DE ANGELIS, KATIA/I-6098-2016
OI Irigoyen, maria Claudia/0000-0003-2097-3662; Caldini, Elia
   Garcia/0000-0001-5322-3812; DE ANGELIS, KATIA/0000-0002-3640-9049;
   Ulloa, Luis/0000-0002-7702-7549
FU CNPq [457200/2014-6, 309292/2014-0]; FAPESP [2018/06872-3,
   2015/11223-6]; CAPES [88881.062178/2014-01]; CNPq Fellowship (CNPq-BPQ)
FX This study was supported by CNPq (457200/2014-6; 309292/2014-0) and
   FAPESP (2018/06872-3; 2015/11223-6); CAPES (88881.062178/2014-01). Katia
   De Angelis and Maria-Claudia Irigoyen are recipients of CNPq Fellowship
   (CNPq-BPQ).
CR AEBI H, 1984, METHOD ENZYMOL, V105, P121
   Agarwal D, 2012, ANTIOXID REDOX SIGN, V16, P139, DOI 10.1089/ars.2011.3967
   Basciano Heather, 2005, Nutr Metab (Lond), V2, P5, DOI 10.1186/1743-7075-2-5
   Beltrán-Sánchez H, 2013, J AM COLL CARDIOL, V62, P697, DOI 10.1016/j.jacc.2013.05.064
   Bertagnolli M, 2006, J HYPERTENS, V24, P2437, DOI 10.1097/01.hjh.0000251905.08547.17
   Borovikova LV, 2000, NATURE, V405, P458, DOI 10.1038/35013070
   BRISTOW JD, 1969, CIRCULATION, V39, P48, DOI 10.1161/01.CIR.39.1.48
   Brito JO, 2008, BRAZ J MED BIOL RES, V41, P804, DOI 10.1590/S0100-879X2008005000030
   Buege J A, 1978, Methods Enzymol, V52, P302
   Castro MC, 2015, LIFE SCI, V137, P1, DOI 10.1016/j.lfs.2015.07.010
   Conti FF, 2014, BMC CARDIOVASC DISOR, V14, DOI 10.1186/1471-2261-14-185
   De Angelis K, 2012, AM J PHYSIOL-REG I, V302, pR950, DOI 10.1152/ajpregu.00450.2011
   de Jongh RT, 2004, CIRCULATION, V109, P2529, DOI 10.1161/01.CIR.0000129772.26647.6F
   de Oliveira Otto M. C., 2016, PLOS ONE, V11
   Delbosc S, 2005, ATHEROSCLEROSIS, V179, P43, DOI 10.1016/j.atherosclerosis.2004.10.018
   Elliott SS, 2002, AM J CLIN NUTR, V76, P911, DOI 10.1093/ajcn/76.5.911
   Evelson P, 2001, ARCH BIOCHEM BIOPHYS, V388, P261, DOI 10.1006/abbi.2001.2292
   Farah V, 2006, AUTON NEUROSCI-BASIC, V130, P41, DOI 10.1016/j.autneu.2006.05.006
   Francini F, 2010, LIFE SCI, V86, P965, DOI 10.1016/j.lfs.2010.05.005
   Girard A, 2006, NUTRITION, V22, P758, DOI 10.1016/j.nut.2006.05.006
   Grassi G, 2009, BLOOD PRESSURE, V18, P7, DOI 10.1080/08037050802677695
   Guilbert J J, 2003, Educ Health (Abingdon), V16, P230
   Hernández-Salinas R, 2015, BIOL RES, V48, DOI 10.1186/s40659-015-0045-4
   Huston JM, 2006, J EXP MED, V203, P1623, DOI 10.1084/jem.20052362
   Irigoyen MC, 2016, CURR HYPERTENS REP, V18, DOI 10.1007/s11906-016-0642-9
   IRIGOYEN MC, 1995, HYPERTENSION, V26, P1111, DOI 10.1161/01.HYP.26.6.1111
   Johansson M, 2007, J HYPERTENS, V25, P163, DOI 10.1097/01.hjh.0000254377.18983.eb
   KOJIMA M, 1989, J HYPERTENS, V7, P873, DOI 10.1097/00004872-198911000-00004
   La Rovere MT, 1998, LANCET, V351, P478
   Landmesser U, 2004, CIRCULATION, V109, P27, DOI 10.1161/01.CIR.0000129501.88485.1f
   MARKLUND SL, 1985, MUTAT RES, V148, P129, DOI 10.1016/0027-5107(85)90216-7
   Masson GS, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094927
   Moraes-Silva IC, 2013, J APPL PHYSIOL, V114, P786, DOI 10.1152/japplphysiol.00586.2012
   Fariña JP, 2013, CLIN SCI, V125, P87, DOI 10.1042/CS20120470
   PICK E, 1980, J IMMUNOL METHODS, V38, P161, DOI 10.1016/0022-1759(80)90340-3
   Porto ML, 2015, TOXICOL IN VITRO, V29, P1977, DOI 10.1016/j.tiv.2015.08.006
   REZNICK AZ, 1994, METHOD ENZYMOL, V233, P357
   Rice BH, 2011, ADV NUTR, V2, P396, DOI 10.3945/an.111.000646
   Rodrigues B, 2007, CARDIOVASC DIABETOL, V6, DOI 10.1186/1475-2840-6-38
   Sanches IC, 2012, MENOPAUSE, V19, P562, DOI 10.1097/gme.0b013e3182358c9c
   Serné EH, 2007, HYPERTENSION, V50, P204, DOI 10.1161/HYPERTENSIONAHA.107.089680
   Shimamoto K, 2006, CLIN EXP HYPERTENS, V28, P543, DOI 10.1080/10641960600851900
   Simonet S, 2012, BRIT J PHARMACOL, V167, P854, DOI 10.1111/j.1476-5381.2012.02062.x
   Tracey KJ, 2002, NATURE, V420, P853, DOI 10.1038/nature01321
   Van Gaal LF, 2006, NATURE, V444, P875, DOI 10.1038/nature05487
   WEKSTEIN DR, 1965, AM J PHYSIOL, V208, P1259, DOI 10.1152/ajplegacy.1965.208.6.1259
   Wiernsperger NF, 2001, CLIN HEMORHEOL MICRO, V25, P55
NR 47
TC 17
Z9 17
U1 0
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 5
PY 2018
VL 8
AR 8578
DI 10.1038/s41598-018-26816-4
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GI1HZ
UT WOS:000434122600003
PM 29872081
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Thomas, JJ
   Ren, J
AF Thomas, Joi J.
   Ren, Jun
TI Obstructive sleep apnoea and cardiovascular complications: perception
   versus knowledge
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Review
DE cardiovascular disease; obstructive sleep apnoea; risk factor
ID CHRONIC INTERMITTENT HYPOXIA; FATTY LIVER-DISEASE; POSITIVE AIRWAY
   PRESSURE; EXCESSIVE DAYTIME SLEEPINESS; RANDOMIZED CONTROLLED-TRIAL;
   CORONARY-ARTERY-DISEASE; NECROSIS-FACTOR-ALPHA; METABOLIC SYNDROME;
   HEART-FAILURE; SYMPATHETIC ACTIVITY
AB 1. Epidemiological evidence has confirmed that obstructive sleep apnoea (OSA) significantly promotes cardiovascular risk, independent of age, sex, race and other common risk factors for cardiovascular diseases, such as smoking, drinking, obesity, diabetes mellitus, dyslipidaemia and hypertension.
   2. Patients with severe OSA exhibit a higher prevalence of coronary artery disease, heart failure and stroke. Despite the tight correlation between sleep apnoea and these comorbidities, the mechanisms behind increased cardiovascular risk in OSA remain elusive. Several theories have been postulated, including sympathetic activation, endothelial dysfunction, oxidative stress and inflammation.
   3. The association between OSA and cardiovascular diseases may be rather complicated and compounded by the presence of components of metabolic syndrome, such as obesity, hypertension, diabetes mellitus and dyslipidaemia. The present minireview updates current knowledge with regard to the cardiovascular sequelae of OSA and the mechanisms involved.
C1 [Thomas, Joi J.; Ren, Jun] Univ Wyoming, Coll Hlth Sci, Div Kinesiol & Hlth & Biomed Sci, Laramie, WY 82071 USA.
C3 University of Wyoming
RP Ren, J (corresponding author), Univ Wyoming, Coll Hlth Sci, Div Kinesiol & Hlth & Biomed Sci, Laramie, WY 82071 USA.
EM jren@uwyo.edu
RI Ren, Jun/ACG-5366-2022
OI Ren, Jun/0000-0002-0275-0783
CR Ahmed MH, 2010, WORLD J GASTROENTERO, V16, P4243, DOI 10.3748/wjg.v16.i34.4243
   Aron-Wisnewsky J, 2012, J HEPATOL, V56, P225, DOI 10.1016/j.jhep.2011.04.022
   Barceló A, 2011, EUR RESPIR J, V37, P1418, DOI 10.1183/09031936.00050410
   Brisco Meredith A, 2010, Curr Heart Fail Rep, V7, P175, DOI 10.1007/s11897-010-0033-5
   Budhiraja R, 2010, RESP CARE, V55, P1322
   Bugianesi E, 2005, DIABETOLOGIA, V48, P634, DOI 10.1007/s00125-005-1682-x
   Butt M, 2010, INT J CARDIOL, V139, P7, DOI 10.1016/j.ijcard.2009.05.021
   CARLSON JT, 1993, CHEST, V103, P1763, DOI 10.1378/chest.103.6.1763
   Chami HA, 2011, CIRCULATION, V123, P1280, DOI 10.1161/CIRCULATIONAHA.110.974022
   Chung S, 2010, RESPIRATION, V79, P363, DOI 10.1159/000228905
   Cloward TV, 2003, CHEST, V124, P594, DOI 10.1378/chest.124.2.594
   Daltro C, 2010, OBES SURG, V20, P1536, DOI 10.1007/s11695-010-0212-1
   Das Aneesa M, 2009, Expert Rev Cardiovasc Ther, V7, P619, DOI 10.1586/erc.09.25
   Del Rio R, 2011, BRAIN RES, V1395, P74, DOI 10.1016/j.brainres.2011.04.028
   Dematteis M, 2009, ILAR J, V50, P262, DOI 10.1093/ilar.50.3.262
   Devulapally K, 2009, HEART FAIL REV, V14, P155, DOI 10.1007/s10741-008-9101-2
   Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI23621
   Dorkova Z, 2008, CHEST, V134, P686, DOI 10.1378/chest.08-0556
   Drager LF, 2007, AM J RESP CRIT CARE, V176, P706, DOI 10.1164/rccm.200703-500OC
   Drager LF, 2011, CHEST, V140, P534, DOI 10.1378/chest.10-2223
   Drager LF, 2010, AM J CARDIOL, V105, P1135, DOI 10.1016/j.amjcard.2009.12.017
   Drager LF, 2009, J HYPERTENS, V27, P1655, DOI 10.1097/HJH.0b013e32832c6982
   Durán-Cantolla J, 2010, BMJ-BRIT MED J, V341, DOI 10.1136/bmj.c5991
   Dursunoglu D, 2005, EUR RESPIR J, V26, P283, DOI 10.1183/09031936.05.00038804
   Dyugovskaya L, 2002, AM J RESP CRIT CARE, V165, P934, DOI 10.1164/ajrccm.165.7.2104126
   Egea CJ, 2008, SLEEP MED, V9, P660, DOI 10.1016/j.sleep.2007.06.018
   El-Solh AA, 2002, CHEST, V121, P1541, DOI 10.1378/chest.121.5.1541
   Fava C, 2011, SEMIN THROMB HEMOST, V37, P280, DOI 10.1055/s-0031-1273092
   Fletcher EC, 2003, SLEEP, V26, P15, DOI 10.1093/sleep/26.1.15
   Gami AS, 2008, J CARDIOVASC ELECTR, V19, P997, DOI 10.1111/j.1540-8167.2008.01136.x
   Gami AS, 2007, J AM COLL CARDIOL, V49, P565, DOI 10.1016/j.jacc.2006.08.060
   Gottlieb DJ, 2010, CIRCULATION, V122, P352, DOI 10.1161/CIRCULATIONAHA.109.901801
   Greenberg H, 2006, BIOCHEM BIOPH RES CO, V343, P591, DOI 10.1016/j.bbrc.2006.03.015
   GUILLEMINAULT C, 1993, CHEST, V104, P781, DOI 10.1378/chest.104.3.781
   HUDGEL DW, 1992, CHEST, V101, P541, DOI 10.1378/chest.101.2.541
   Ip MSM, 2004, AM J RESP CRIT CARE, V169, P348, DOI 10.1164/rccm.200306-767OC
   Jean-Louis G, 2010, EXPERT REV CARDIOVAS, V8, P995, DOI 10.1586/ERC.10.55
   Julien C, 2003, RESP PHYSIOL NEUROBI, V139, P21, DOI 10.1016/j.resp.2003.09.005
   Jun J, 2008, AM J PHYSIOL-REG I, V295, pR1274, DOI 10.1152/ajpregu.90346.2008
   Kahwash Rami, 2011, Curr Heart Fail Rep, V8, P72, DOI 10.1007/s11897-010-0037-1
   Karkoulias K, 2010, CURR MED CHEM, V17, P1059
   Kasai T, 2011, J AM COLL CARDIOL, V57, P119, DOI 10.1016/j.jacc.2010.08.627
   Kent BD, 2011, RESP PHYSIOL NEUROBI, V178, P475, DOI 10.1016/j.resp.2011.03.015
   Khayat R, 2009, HEART FAIL REV, V14, P143, DOI 10.1007/s10741-008-9112-z
   Khayat RN, 2008, CHEST, V134, P1162, DOI 10.1378/chest.08-0346
   Kohler M, 2009, THORAX, V64, P67, DOI 10.1136/thx.2008.097931
   Kohler M, 2010, NAT REV CARDIOL, V7, P677, DOI 10.1038/nrcardio.2010.145
   Kohler M, 2009, RESPIRATION, V78, P141, DOI 10.1159/000170785
   Krawczyk M, 2010, BEST PRACT RES CL GA, V24, P695, DOI 10.1016/j.bpg.2010.08.005
   Lavie L, 2003, SLEEP MED REV, V7, P35, DOI 10.1053/smrv.2002.0261
   Lavie L, 2010, J SLEEP RES, V19, P139, DOI 10.1111/j.1365-2869.2009.00789.x
   Lee CH, 2011, J CLIN SLEEP MED, V7, P616, DOI 10.5664/jcsm.1464
   Li JG, 2005, J APPL PHYSIOL, V99, P1643, DOI 10.1152/japplphysiol.00522.2005
   Li NF, 2010, CLIN EXP HYPERTENS, V32, P54, DOI 10.3109/10641960902993087
   Lin QC, 2012, SLEEP BREATH, V16, P571, DOI 10.1007/s11325-011-0544-7
   Lozano L, 2010, J HYPERTENS, V28, P2161, DOI 10.1097/HJH.0b013e32833b9c63
   Ma S, 2008, NEUROSCIENCE, V154, P1639, DOI 10.1016/j.neuroscience.2008.04.068
   McArdle N, 2007, AM J RESP CRIT CARE, V175, P190, DOI 10.1164/rccm.200602-270OC
   Mehra R, 2006, AM J RESP CRIT CARE, V173, P910, DOI 10.1164/rccm.200509-1442OC
   Mehra R, 2006, ARCH INTERN MED, V166, P1725, DOI 10.1001/archinte.166.16.1725
   Mishra P, 2008, LIVER INT, V28, P1080, DOI 10.1111/j.1478-3231.2008.01822.x
   Mohsenin V, 2011, RESP MED, V105, P801, DOI 10.1016/j.rmed.2011.01.001
   Mooe T, 1996, CORONARY ARTERY DIS, V7, P475, DOI 10.1097/00019501-199606000-00011
   Moore JB, 2010, P NUTR SOC, V69, P211, DOI 10.1017/S0029665110000030
   Musso G, 2009, PROG LIPID RES, V48, P1, DOI 10.1016/j.plipres.2008.08.001
   Musso G, 2012, SEMIN LIVER DIS, V32, P49, DOI 10.1055/s-0032-1306426
   Nakashima H, 2006, EUR HEART J, V27, P2317, DOI 10.1093/eurheartj/ehl219
   Narkiewicz K, 1998, CIRCULATION, V98, P772, DOI 10.1161/01.CIR.98.8.772
   Navarro-Gonzalez JF, 2008, J HYPERTENS, V26, P2168, DOI 10.1097/HJH.0b013e32830e2545
   Norman D, 2008, SLEEP, V31, P121, DOI 10.1093/sleep/31.1.121
   O'Connor GT, 2009, AM J RESP CRIT CARE, V179, P1159, DOI 10.1164/rccm.200712-1809OC
   O'Driscoll DM, 2011, SLEEP MED, V12, P483, DOI 10.1016/j.sleep.2010.09.015
   Peppard PE, 2009, J CLIN SLEEP MED, V5, P404
   Peppard PE, 2000, NEW ENGL J MED, V342, P1378, DOI 10.1056/NEJM200005113421901
   PINTO JMB, 1993, J APPL PHYSIOL, V75, P1439, DOI 10.1152/jappl.1993.75.4.1439
   Punjabi NM, 2009, PLOS MED, V6, DOI 10.1371/journal.pmed.1000132
   Quercioli A, 2010, SLEEP BREATH, V14, P261, DOI 10.1007/s11325-010-0338-3
   Roger VL, 2011, CIRCULATION, V123, pE18, DOI 10.1161/CIR.0b013e3182009701
   Ryan S, 2005, CIRCULATION, V112, P2660, DOI 10.1161/CIRCULATIONAHA.105.556746
   Savransky V, 2007, AM J PHYSIOL-GASTR L, V293, pG871, DOI 10.1152/ajpgi.00145.2007
   Savransky V, 2007, AM J RESP CRIT CARE, V175, P1290, DOI 10.1164/rccm.200612-1771OC
   Shahar E, 2001, AM J RESP CRIT CARE, V163, P19, DOI 10.1164/ajrccm.163.1.2001008
   Shamsuzzaman ASM, 2003, JAMA-J AM MED ASSOC, V290, P1906, DOI 10.1001/jama.290.14.1906
   Sharma SK, 2011, NEW ENGL J MED, V365, P2277, DOI 10.1056/NEJMoa1103944
   Shivalkar B, 2006, J AM COLL CARDIOL, V47, P1433, DOI 10.1016/j.jacc.2005.11.054
   Shpirer I, 2010, LUNG, V188, P301, DOI 10.1007/s00408-009-9219-6
   Singh H, 2005, DIGEST DIS SCI, V50, P2338, DOI 10.1007/s10620-005-3058-y
   SOMERS VK, 1995, J CLIN INVEST, V96, P1897, DOI 10.1172/JCI118235
   Sorajja D, 2008, CHEST, V133, P927, DOI 10.1378/chest.07-2544
   Tamaki S, 2009, INTERNAL MED, V48, P1255, DOI 10.2169/internalmedicine.48.2366
   Thomopoulos C, 2009, J HUM HYPERTENS, V23, P65, DOI 10.1038/jhh.2008.101
   Tian JL, 2010, CHINESE MED J-PEKING, V123, P89, DOI 10.3760/cma.j.issn.0366-6999.2010.01.016
   Tsioufis C, 2011, INT J HYPERTENS, V2011, DOI 10.4061/2011/642416
   Vanni E, 2010, DIGEST LIVER DIS, V42, P320, DOI 10.1016/j.dld.2010.01.016
   Vgontzas AN, 2008, EUR J CLIN INVEST, V38, P585, DOI 10.1111/j.1365-2362.2008.01984.x
   Vgontzas AN, 1997, J CLIN ENDOCR METAB, V82, P1313, DOI 10.1210/jc.82.5.1313
   Volgin DV, 2006, AUTON NEUROSCI-BASIC, V126, P93, DOI 10.1016/j.autneu.2006.03.013
   Wang HQ, 2007, J AM COLL CARDIOL, V49, P1625, DOI 10.1016/j.jacc.2006.12.046
   Young T, 2002, AM J RESP CRIT CARE, V165, P1217, DOI 10.1164/rccm.2109080
   Yue HJ, 2009, SLEEP BREATH, V13, P263, DOI 10.1007/s11325-008-0242-2
NR 100
TC 25
Z9 27
U1 1
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD DEC
PY 2012
VL 39
IS 12
BP 995
EP 1003
DI 10.1111/1440-1681.12024
PG 9
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 044IK
UT WOS:000311612600002
PM 23082844
DA 2025-06-11
ER

PT J
AU Menikdiwela, KR
   Ramalingam, L
   Rasha, F
   Wang, S
   Dufour, JM
   Kalupahana, NS
   Sunahara, KKS
   Martins, JO
   Moustaid-Moussa, N
AF Menikdiwela, Kalhara R.
   Ramalingam, Latha
   Rasha, Fahmida
   Wang, Shu
   Dufour, Jannette M.
   Kalupahana, Nishan S.
   Sunahara, Karen K. S.
   Martins, Joilson O.
   Moustaid-Moussa, Naima
TI Autophagy in metabolic syndrome: breaking the wheel by targeting the
   renin-angiotensin system
SO CELL DEATH & DISEASE
LA English
DT Review
ID ENDOPLASMIC-RETICULUM STRESS; ADIPOSE-TISSUE MACROPHAGES; INDUCED
   INSULIN-RESISTANCE; ACTIVATED RECEPTOR-GAMMA; PANCREATIC BETA-CELL;
   OXIDATIVE STRESS; BLOOD-PRESSURE; CARDIOMYOCYTE AUTOPHAGY; DEFECTIVE
   REGULATION; MOLECULAR MACHINERY
AB Metabolic syndrome (MetS) is a complex, emerging epidemic which disrupts the metabolic homeostasis of several organs, including liver, heart, pancreas, and adipose tissue. While studies have been conducted in these research areas, the pathogenesis and mechanisms of MetS remain debatable. Lines of evidence show that physiological systems, such as the renin-angiotensin system (RAS) and autophagy play vital regulatory roles in MetS. RAS is a pivotal system known for controlling blood pressure and fluid balance, whereas autophagy is involved in the degradation and recycling of cellular components, including proteins. Although RAS is activated in MetS, the interrelationship between RAS and autophagy varies in glucose homeostatic organs and their cross talk is poorly understood. Interestingly, autophagy is attenuated in the liver during MetS, whereas autophagic activity is induced in adipose tissue during MetS, indicating tissue-specific discordant roles. We discuss in vivo and in vitro studies conducted in metabolic tissues and dissect their tissue-specific effects. Moreover, our review will focus on the molecular mechanisms by which autophagy orchestrates MetS and the ways future treatments could target RAS in order to achieve metabolic homeostasis.
C1 [Menikdiwela, Kalhara R.; Ramalingam, Latha; Rasha, Fahmida; Wang, Shu; Kalupahana, Nishan S.; Moustaid-Moussa, Naima] Texas Tech Univ, Dept Nutr Sci, Lubbock, TX 79409 USA.
   [Menikdiwela, Kalhara R.; Ramalingam, Latha; Rasha, Fahmida; Wang, Shu; Dufour, Jannette M.; Kalupahana, Nishan S.; Moustaid-Moussa, Naima] Texas Tech Univ, Obes Res Inst, Lubbock, TX 79409 USA.
   [Dufour, Jannette M.] Texas Tech Univ, Dept Cell Biol & Biochem, Hlth Sci Ctr, Lubbock, TX 79409 USA.
   [Kalupahana, Nishan S.] Univ Peradeniya, Fac Med, Dept Physiol, Peradeniya, Sri Lanka.
   [Sunahara, Karen K. S.] Univ Sao Paulo, Dept Expt Physiopathol, Med Sch, Sao Paulo, Brazil.
   [Martins, Joilson O.] Univ Sao Paulo FCF USP, Dept Clin & Toxicol Anal, Lab Immunoendocrinol, Sch Pharmaceut Sci, Sao Paulo, Brazil.
C3 Texas Tech University System; Texas Tech University; Texas Tech
   University System; Texas Tech University; Texas Tech University System;
   Texas Tech University Health Sciences Center Lubbock; University of
   Peradeniya; Universidade de Sao Paulo; Universidade de Sao Paulo
RP Moustaid-Moussa, N (corresponding author), Texas Tech Univ, Dept Nutr Sci, Lubbock, TX 79409 USA.; Moustaid-Moussa, N (corresponding author), Texas Tech Univ, Obes Res Inst, Lubbock, TX 79409 USA.
EM naima.moustaid-moussa@ttu.edu
RI Kalupahana, Nishan/E-1913-2011; Ramalingam, Latha/M-8438-2015; Martins,
   Joilson O./G-4367-2011; Moustaid-Moussa, Naima/B-9067-2014
OI Martins, Joilson O./0000-0003-2630-7038; Wang, Shu/0000-0001-8078-9942;
   Sunahara, Karen/0000-0003-2513-0840; Rasha, Fahmida
   Akter/0000-0003-1369-3806; Ramalingam, Latha/0000-0002-4856-7327;
   Moustaid-Moussa, Naima/0000-0002-7508-8030
FU SPRINT award (Texas Tech University); SPRINT award (FAPESP)
FX This work was supported in part by a SPRINT award (Texas Tech University
   and FAPESP agreement) to N.M.M., L.R. and J.O.M.
CR Abdellatif M, 2018, CIRC RES, V123, P803, DOI 10.1161/CIRCRESAHA.118.312208
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Baba SP, 2018, J MOL CELL CARDIOL, V118, P183, DOI 10.1016/j.yjmcc.2018.04.002
   Baerga R, 2009, AUTOPHAGY, V5, P1118, DOI 10.4161/auto.5.8.9991
   BOREK M, 1987, PHARMACOTHERAPY, V7, P133
   Cai JJ, 2018, CELL REP, V25, P1708, DOI 10.1016/j.celrep.2018.10.040
   Castets P, 2013, AUTOPHAGY, V9, P1435, DOI 10.4161/auto.25722
   Castoldi A, 2016, FRONT IMMUNOL, V6, DOI 10.3389/fimmu.2015.00637
   Chambrier C, 2002, OBES RES, V10, P518, DOI 10.1038/oby.2002.70
   Chao YM, 2013, HYPERTENSION, V61, P1270, DOI 10.1161/HYPERTENSIONAHA.111.00469
   Chen DX, 2016, INT IMMUNOPHARMACOL, V34, P107, DOI 10.1016/j.intimp.2016.02.023
   Chen F, 2014, CELL PHYSIOL BIOCHEM, V33, P1058, DOI 10.1159/000358676
   Cheng Z, 2018, J MOL CELL CARDIOL, V125, P117, DOI 10.1016/j.yjmcc.2018.08.028
   Codogno P, 2010, CELL METAB, V11, P449, DOI 10.1016/j.cmet.2010.05.006
   Crisan TO, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0018666
   Cuervo AM, 2004, TRENDS CELL BIOL, V14, P70, DOI 10.1016/j.tcb.2003.12.002
   Dai DF, 2011, CIRC RES, V108, P837, DOI 10.1161/CIRCRESAHA.110.232306
   de Kloet AD, 2010, PHYSIOL BEHAV, V100, P525, DOI 10.1016/j.physbeh.2010.03.018
   de Luxán-Delgado B, 2016, J PINEAL RES, V61, P108, DOI 10.1111/jpi.12333
   Ding Y, 2014, SEMIN NEPHROL, V34, P62, DOI 10.1016/j.semnephrol.2013.11.009
   Diniz GP, 2009, BASIC RES CARDIOL, V104, P653, DOI 10.1007/s00395-009-0043-1
   Djavaheri-Mergny M, 2006, J BIOL CHEM, V281, P30373, DOI 10.1074/jbc.M602097200
   du Toit EF, 2005, BASIC RES CARDIOL, V100, P346, DOI 10.1007/s00395-005-0528-5
   Dupont N, 2011, EMBO J, V30, P4701, DOI 10.1038/emboj.2011.398
   Ebato C, 2008, CELL METAB, V8, P325, DOI 10.1016/j.cmet.2008.08.009
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Engeli S, 2003, INT J BIOCHEM CELL B, V35, P807, DOI 10.1016/S1357-2725(02)00311-4
   Finckenberg P, 2012, HYPERTENSION, V59, P76, DOI 10.1161/HYPERTENSIONAHA.111.179457
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Fujitani Y, 2009, ISLETS, V1, P151, DOI 10.4161/isl.1.2.9057
   Fujitani Y, 2009, AUTOPHAGY, V5, P280, DOI 10.4161/auto.5.2.7656
   Gao Q, 2016, MOL NEUROBIOL, V53, P2911, DOI 10.1007/s12035-015-9177-3
   Grundy SM, 2016, TRENDS CARDIOVAS MED, V26, P364, DOI 10.1016/j.tcm.2015.10.004
   Guilluy C, 2010, NAT MED, V16, P183, DOI 10.1038/nm.2079
   Gwinn DM, 2008, MOL CELL, V30, P214, DOI 10.1016/j.molcel.2008.03.003
   Hadi NR, 2017, INT J CARDIOL, V230, P269, DOI 10.1016/j.ijcard.2016.12.127
   Hamacher-Brady A, 2006, J BIOL CHEM, V281, P29776, DOI 10.1074/jbc.M603783200
   Hara K, 2000, BRIT J NUTR, V84, pS235, DOI 10.1079/096582197388608
   Harris J, 2007, IMMUNITY, V27, P505, DOI 10.1016/j.immuni.2007.07.022
   Harris J, 2011, CYTOKINE, V56, P140, DOI 10.1016/j.cyto.2011.08.022
   Harris J, 2011, J BIOL CHEM, V286, P9587, DOI 10.1074/jbc.M110.202911
   Harris J, 2008, J INFECT DIS, V198, P1842, DOI 10.1086/593174
   Hung WW, 2011, CARDIOVASC DRUG THER, V25, P3, DOI 10.1007/s10557-010-6274-4
   Ignacio-Souza LM, 2014, ENDOCRINOLOGY, V155, P2831, DOI 10.1210/en.2014-1090
   Inoki K, 2002, NAT CELL BIOL, V4, P648, DOI 10.1038/ncb839
   Jiang T, 2013, PHARMACOL RES, V71, P61, DOI 10.1016/j.phrs.2013.03.001
   JUN JY, 2018, DIABETES S1, V67, DOI DOI 10.2337/DB18-1979-P
   Jung CH, 2009, MOL BIOL CELL, V20, P1992, DOI 10.1091/mbc.E08-12-1249
   Jung HS, 2008, CELL METAB, V8, P318, DOI 10.1016/j.cmet.2008.08.013
   Kalupahana NS, 2012, OBES REV, V13, P136, DOI 10.1111/j.1467-789X.2011.00942.x
   Kalupahana NS, 2012, CRIT REV BIOCHEM MOL, V47, P379, DOI 10.3109/10409238.2012.694843
   Kalupahana NS, 2012, OBESITY, V20, P48, DOI 10.1038/oby.2011.299
   Kamada Y, 2000, J CELL BIOL, V150, P1507, DOI 10.1083/jcb.150.6.1507
   Kim J, 2001, J CELL BIOL, V152, P51, DOI 10.1083/jcb.152.1.51
   Kim JS, 2008, HEPATOLOGY, V47, P1725, DOI 10.1002/hep.22187
   Kim JA, 2012, AM J PHYSIOL-ENDOC M, V302, pE201, DOI 10.1152/ajpendo.00497.2011
   Kim J, 2011, NAT CELL BIOL, V13, P132, DOI 10.1038/ncb2152
   Kim KH, 2013, NAT MED, V19, P83, DOI 10.1038/nm.3014
   Kim S, 2006, J BIOMED BIOTECHNOL, DOI 10.1155/JBB/2006/27012
   Kim YC, 2015, J CLIN INVEST, V125, P25, DOI 10.1172/JCI73939
   KLIEWER SA, 1995, CELL, V83, P813, DOI 10.1016/0092-8674(95)90194-9
   Klionsky DJ, 2000, SCIENCE, V290, P1717, DOI 10.1126/science.290.5497.1717
   Klionsky DJ, 2005, J CELL SCI, V118, P7, DOI 10.1242/jcs.01620
   Komatsu M, 2005, J CELL BIOL, V169, P425, DOI 10.1083/jcb.200412022
   Kosacka J, 2015, MOL CELL ENDOCRINOL, V409, P21, DOI 10.1016/j.mce.2015.03.015
   Kovsan J, 2011, J CLIN ENDOCR METAB, V96, pE268, DOI 10.1210/jc.2010-1681
   Kuma A, 2004, NATURE, V432, P1032, DOI 10.1038/nature03029
   Kwanten WJ, 2014, WORLD J GASTROENTERO, V20, P7325, DOI 10.3748/wjg.v20.i23.7325
   Lapaquette P GJ, 2015, MEDIAT INFLAMM, V2015, P1
   Lavoie JL, 2003, ENDOCRINOLOGY, V144, P2179, DOI 10.1210/en.2003-0150
   LeMieux MJ, 2016, OBESITY, V24, P359, DOI 10.1002/oby.21352
   Li ST, 2017, HEPATOLOGY, V66, P936, DOI 10.1002/hep.29229
   Libby P, 2002, NATURE, V420, P868, DOI 10.1161/ATVBAHA.108.179705
   Lin L, 2016, J CELL MOL MED, V20, P48, DOI 10.1111/jcmm.12687
   Liu HY, 2009, J BIOL CHEM, V284, P31484, DOI 10.1074/jbc.M109.033936
   Liu Y, 2015, CELL DEATH DIFFER, V22, P367, DOI 10.1038/cdd.2014.143
   Long L, 2013, CIRC RES, V112, P1159, DOI 10.1161/CIRCRESAHA.111.300483
   Ma XJM, 2009, NAT REV MOL CELL BIO, V10, P307, DOI 10.1038/nrm2672
   Maïano C, 2016, OBES REV, V17, P599, DOI 10.1111/obr.12408
   Mao N, 2016, CELL BIOL INT, V40, P917, DOI 10.1002/cbin.10634
   Martins R, 2016, AGING CELL, V15, P196, DOI 10.1111/acel.12427
   Matsui Y, 2007, CIRC RES, V100, P914, DOI 10.1161/01.RES.0000261924.76669.36
   Matsuzawa-Nagata N, 2008, METABOLISM, V57, P1071, DOI 10.1016/j.metabol.2008.03.010
   Mei S, 2011, J PHARMACOL EXP THER, V339, P487, DOI 10.1124/jpet.111.184341
   Mei Y, 2015, BBA-MOL BASIS DIS, V1852, P243, DOI 10.1016/j.bbadis.2014.05.005
   Meng QY, 2011, J BIOL CHEM, V286, P32324, DOI 10.1074/jbc.M111.254417
   Menikdiwela KR, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-44834-8
   Michael SK, 2008, P NATL ACAD SCI USA, V105, P6702, DOI 10.1073/pnas.0802128105
   Mizushima N, 2005, CELL DEATH DIFFER, V12, P1535, DOI 10.1038/sj.cdd.4401728
   Mizushima N, 2007, GENE DEV, V21, P2861, DOI 10.1101/gad.1599207
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   Morrell NW, 2009, J AM COLL CARDIOL, V54, pS20, DOI 10.1016/j.jacc.2009.04.018
   Moulis M, 2018, CELLS-BASEL, V7, DOI 10.3390/cells7100149
   Nakahira K, 2011, NAT IMMUNOL, V12, P222, DOI 10.1038/ni.1980
   Nakai A, 2007, NAT MED, V13, P619, DOI 10.1038/nm1574
   Namkoong S, 2018, MOL CELLS, V41, P3, DOI 10.14348/molcells.2018.2213
   Nishida K, 2009, CELL DEATH DIFFER, V16, P31, DOI 10.1038/cdd.2008.163
   Noda T, 1998, J BIOL CHEM, V273, P3963, DOI 10.1074/jbc.273.7.3963
   NOVIKOFF AB, 1980, J CELL BIOL, V87, P180, DOI 10.1083/jcb.87.1.180
   Nuñez CE, 2013, INT J OBESITY, V37, P1473, DOI 10.1038/ijo.2013.27
   Ogihara T, 2002, HYPERTENSION, V40, P872, DOI 10.1161/01.HYP.0000040262.48405.A8
   Öst A, 2010, MOL MED, V16, P235, DOI 10.2119/molmed.2010.00023
   Parlakpinar H, 2011, CYTOKINE, V56, P688, DOI 10.1016/j.cyto.2011.09.002
   Patel S, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0845-3
   PFEIFER U, 1978, J CELL BIOL, V78, P152, DOI 10.1083/jcb.78.1.152
   Porrello ER, 2009, AUTOPHAGY, V5, P1215, DOI 10.4161/auto.5.8.10153
   Porrello ER, 2009, HYPERTENSION, V53, P1032, DOI 10.1161/HYPERTENSIONAHA.108.128488
   Potter CJ, 2002, NAT CELL BIOL, V4, P658, DOI 10.1038/ncb840
   Premaratna SD, 2012, INT J OBESITY, V36, P233, DOI 10.1038/ijo.2011.95
   Prieur X, 2011, DIABETES, V60, P797, DOI 10.2337/db10-0705
   Putnam K, 2012, AM J PHYSIOL-HEART C, V302, pH1219, DOI 10.1152/ajpheart.00796.2011
   Pyo JO, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3300
   Qian MJ, 2017, CLIN TRANSL MED, V6, DOI 10.1186/s40169-017-0154-5
   Qian QW, 2019, CELL MOL GASTROENTER, V8, P95, DOI 10.1016/j.jcmgh.2019.03.005
   Qian QW, 2018, DIABETES, V67, P193, DOI 10.2337/db17-0223
   Quan W, 2012, DIABETOLOGIA, V55, P392, DOI 10.1007/s00125-011-2350-y
   Rajagopalan S, 1996, J CLIN INVEST, V97, P1916, DOI 10.1172/JCI118623
   Ramalingam L, 2017, BBA-MOL BASIS DIS, V1863, P1106, DOI 10.1016/j.bbadis.2016.07.019
   Reaven GM, 2004, DIABETES CARE, V27, P1011, DOI 10.2337/diacare.27.4.1011
   Rocchi Altea, 2015, Front Biol (Beijing), V10, P154
   Rosen ED, 1999, MOL CELL, V4, P611, DOI 10.1016/S1097-2765(00)80211-7
   Rothermel BA, 2007, AUTOPHAGY, V3, P632, DOI 10.4161/auto.4913
   Rupérez C, 2018, INT J CARDIOL, V260, P163, DOI 10.1016/j.ijcard.2018.02.109
   Sadoshima J, 2008, AUTOPHAGY, V4, P402, DOI 10.4161/auto.5924
   Saito T, 2016, AUTOPHAGY, V12, P579, DOI 10.1080/15548627.2016.1145326
   Saitoh T, 2008, NATURE, V456, P264, DOI 10.1038/nature07383
   Sánchez JLG, 2002, EUR J ENDOCRINOL, V147, P495, DOI 10.1530/eje.0.1470495
   Sciarretta S, 2018, ANNU REV PHYSIOL, V80, P1, DOI 10.1146/annurev-physiol-021317-121427
   Scott RC, 2004, DEV CELL, V7, P167, DOI 10.1016/j.devcel.2004.07.009
   Shen QQ, 2018, CELL PHYSIOL BIOCHEM, V51, P1751, DOI 10.1159/000495678
   Shibata M, 2009, BIOCHEM BIOPH RES CO, V382, P419, DOI 10.1016/j.bbrc.2009.03.039
   Singh R, 2009, J CLIN INVEST, V119, P3329, DOI 10.1172/JCI39228
   Singh R, 2009, NATURE, V458, P1131, DOI 10.1038/nature07976
   Singh RK, 2012, INT J OPT, V2012, DOI [10.1155/2012/282041, 10.1155/2012/832086]
   Soussi H, 2016, AUTOPHAGY, V12, P588, DOI 10.1080/15548627.2015.1106667
   Su FF, 2018, INT J MED SCI, V15, P1508, DOI 10.7150/ijms.28106
   Sutherland JP, 2004, METAB SYNDR RELAT D, V2, P82, DOI 10.1089/met.2004.2.82
   Suzuki K, 2007, FEBS LETT, V581, P2156, DOI 10.1016/j.febslet.2007.01.096
   Tang YJ, 2016, SCI REP-UK, V6, P1, DOI 10.1038/srep34607
   TESTA MA, 1993, NEW ENGL J MED, V328, P907, DOI 10.1056/NEJM199304013281302
   TONTONOZ P, 1994, CELL, V79, P1147, DOI 10.1016/0092-8674(94)90006-X
   Travassos LH, 2010, NAT IMMUNOL, V11, P55, DOI 10.1038/ni.1823
   Trayhurn P, 2001, P NUTR SOC, V60, P329, DOI 10.1079/PNS200194
   Tzameli I, 2004, J BIOL CHEM, V279, P36093, DOI 10.1074/jbc.M405346200
   Vitale C, 2005, CARDIOVASC DIABETOL, V4, DOI 10.1186/1475-2840-4-6
   Wang Y, 2017, AM J PHYSIOL-HEART C, V312, pH459, DOI 10.1152/ajpheart.00498.2016
   Ward C, 2016, BBA-MOL CELL BIOL L, V1861, P269, DOI 10.1016/j.bbalip.2016.01.006
   Whaley-Connell A, 2011, AM J NEPHROL, V34, P115, DOI 10.1159/000329327
   Wilson-Fritch L, 2003, MOL CELL BIOL, V23, P1085, DOI 10.1128/MCB.23.3.1085-1094.2003
   Woo Y, 2017, ONCOL LETT, V13, P3579, DOI 10.3892/ol.2017.5872
   Wullschleger S, 2006, CELL, V127, P5
   Xiong XF, 2018, CELL DEATH DIS, V9, DOI 10.1038/s41419-018-1168-7
   Xue H, 2016, AUTOPHAGY, V12, P1129, DOI 10.1080/15548627.2016.1178446
   Yadav A, 2010, AM J PHYSIOL-CELL PH, V299, pC488, DOI 10.1152/ajpcell.00424.2009
   YAMORI Y, 1990, J CARDIOVASC PHARM, V16, pS43, DOI 10.1097/00005344-199000168-00018
   Yang L, 2010, CELL METAB, V11, P467, DOI 10.1016/j.cmet.2010.04.005
   Yousefi S, 2006, NAT CELL BIOL, V8, P1124, DOI 10.1038/ncb1482
   Yuan HX, 2013, AUTOPHAGY, V9, P1983, DOI 10.4161/auto.26058
   Yue ZY, 2003, P NATL ACAD SCI USA, V100, P15077, DOI 10.1073/pnas.2436255100
   Zeng M, 2013, BIOCHEM BIOPH RES CO, V436, P180, DOI 10.1016/j.bbrc.2013.05.070
   Zeyda M, 2007, INT J OBESITY, V31, P1420, DOI 10.1038/sj.ijo.0803632
   Zhang CB, 2013, AM J PHYSIOL-ENDOC M, V305, pE530, DOI 10.1152/ajpendo.00640.2012
   Zhang M, 2015, ELIFE, V4, DOI 10.7554/eLife.11205
   Zhang YM, 2018, NAT REV ENDOCRINOL, V14, P356, DOI 10.1038/s41574-018-0009-1
   Zhang Y, 2009, P NATL ACAD SCI USA, V106, P19860, DOI 10.1073/pnas.0906048106
   Zhao W, 2014, FREE RADICAL BIO MED, V69, P108, DOI 10.1016/j.freeradbiomed.2014.01.002
   Zhong ZY, 2016, CELL, V166, P288, DOI 10.1016/j.cell.2016.05.051
   Zhou M, 2018, EUR REV MED PHARMACO, V22, P5647, DOI 10.26355/eurrev_201809_15831
NR 168
TC 64
Z9 70
U1 0
U2 9
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-4889
J9 CELL DEATH DIS
JI Cell Death Dis.
PD FEB 3
PY 2020
VL 11
IS 2
DI 10.1038/s41419-020-2275-9
PG 17
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA KI5OB
UT WOS:000511398100009
PM 32015340
OA Green Published, gold
DA 2025-06-11
ER

PT S
AU Cerdá, C
   Sánchez, C
   Climent, B
   Vázquez, A
   Iradi, A
   El Amrani, F
   Bediaga, A
   Sáez, GT
AF Cerda, Concha
   Sanchez, Carlos
   Climent, Benjamin
   Vazquez, Antonio
   Iradi, Antonio
   El Amrani, Fatima
   Bediaga, Ana
   Saez, Guillermo T.
BE Camps, J
TI Oxidative Stress and DNA Damage in Obesity-Related Tumorigenesis
SO OXIDATIVE STRESS AND INFLAMMATION IN NON-COMMUNICABLE DISEASES -
   MOLECULAR MECHANISMS AND PERSPECTIVES IN THERAPEUTICS
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
DE Cancer; DNA damage; Free radicals; Obesity
ID BODY-MASS INDEX; BREAST-CANCER CELLS; FACTOR-KAPPA-B; METABOLIC
   SYNDROME; GROWTH-FACTOR; COLON-CANCER; HIGH-FAT; CALORIC RESTRICTION;
   ENDOMETRIAL CANCER; INSULIN-RESISTANCE
AB Reactive oxygen species induce oxidative modification of critical macromolecules. Oxygen derived free radicals may act as potential cytotoxic intermediates inducing inflammatory and degenerative processes, or as signal messengers for the regulation of gene expression. This dual effect mainly depends on the availability of free radicals in terms of concentration, as well as on the environmental characteristics in which they are produced. The formation of free radicals has been proposed to be the linking factor between certain metabolic disturbances and cancer. Circulating mononuclear cells of patients with high cholesterol levels, insulin resistance, metabolic syndrome or obesity present lower levels of antioxidant enzymes and increased concentrations of oxidative stress by-products such as isoprostanes or the DNA oxidized and highly mutagenic base 8-oxo-7,8-dihydro-2 '-deoxyguanosine. Overweight or obese subjects also exhibit hormonal changes as a consequence of the increase of mass fat, and these hormonal alterations have been implicated in the alteration of different signal transduction mechanisms and in cell growth and differentiation. A significant correlation has been found between body mass index and cancer. The biological factors and molecular mechanisms implicated in obesity associated cancer susceptibility will be reviewed.
C1 [Cerda, Concha; Bediaga, Ana] Univ Valencia, Gen Univ Hosp CIBEROBN, Oxidat Stress Commiss SEQC, Serv Clin Anal CDB, Valencia, Spain.
   [Sanchez, Carlos] Univ Valencia, Gen Univ Hosp, Endocrinol & Nutr Unit, Valencia, Spain.
   [Climent, Benjamin] Univ Valencia, Gen Univ Hosp, Serv Internal Med, Valencia, Spain.
   [Vazquez, Antonio] Univ Valencia, Gen Univ Hosp, Serv Gen & Digest Surg, Valencia, Spain.
   [Iradi, Antonio] Univ Valencia, Fac Med CIBEROBN, Dept Physiol, Valencia, Spain.
   [El Amrani, Fatima] Univ Valencia, Fac Med, Dept Biochem & Mol Biol, Valencia 46010, Spain.
   Univ Valencia, Gen Univ Hosp CIBEROBN, Oxidat Stress Commiss SEQC, Serv Clin Analy CDB, Valencia, Spain.
   [Saez, Guillermo T.] Univ Valencia, Oxidat Stress Commiss SEQC, Gen Univ Hosp CDB, Dept Biochem & Mol Biol,Fac Med, Valencia 46010, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; University
   of Valencia; University of Valencia; University of Valencia; University
   of Valencia; University of Valencia; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; University of Valencia; University of
   Valencia; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN;
   University of Valencia
RP Sáez, GT (corresponding author), Univ Valencia, Gen Univ Hosp CIBEROBN, Oxidat Stress Commiss SEQC, Serv Clin Analy CDB, Valencia, Spain.
EM Concermi@gmail.com; Carlos.sanchez@uv.es; Climent_ben@gva.es;
   Vprado.a@gmail.com; Antonio.iradi@uv.es; Yolanda.ben@uv.es;
   anbecol@hotmail.com; Guillermo.saez@uv.es
RI ; Sanchez Juan, Carlos/A-2197-2019
OI Saez, Guillermo/0000-0002-8164-4048; Sanchez Juan,
   Carlos/0000-0002-0319-0722
CR Abdilla N, 2007, J HUM HYPERTENS, V21, P68, DOI 10.1038/sj.jhh.1002105
   Anderson D, 1998, MUTAT RES-FUND MOL M, V398, P151, DOI 10.1016/S0027-5107(97)00271-6
   Arcidiacono B, 2012, EXP DIABETES RES, DOI 10.1155/2012/789174
   Barb D, 2007, AM J CLIN NUTR, V86, p858S, DOI 10.1093/ajcn/86.3.858S
   Barregard L, 2013, ANTIOXID REDOX SIGN, V18, P2377, DOI 10.1089/ars.2012.4714
   Becker Susen, 2009, Archives of Physiology and Biochemistry, V115, P86, DOI 10.1080/13813450902878054
   Bråkenhielm E, 2004, P NATL ACAD SCI USA, V101, P2476, DOI 10.1073/pnas.0308671100
   Bray GA, 2002, J NUTR, V132, p3451S, DOI 10.1093/jn/132.11.3451S
   Brown LA, 2009, OBESITY, V17, P460, DOI 10.1038/oby.2008.590
   Bubici C, 2006, ONCOGENE, V25, P6731, DOI 10.1038/sj.onc.1209936
   Caballero B, 2007, EPIDEMIOL REV, V29, P1, DOI 10.1093/epirev/mxm012
   Calle EE, 2003, NEW ENGL J MED, V348, P1625, DOI 10.1056/NEJMoa021423
   Calle EE, 2004, NAT REV CANCER, V4, P579, DOI 10.1038/nrc1408
   Canonici A, 2008, INT J CANCER, V122, P572, DOI 10.1002/ijc.23164
   Canoy D, 2005, AM J CLIN NUTR, V82, P1203, DOI 10.1093/ajcn/82.6.1203
   Cao Y, 2011, CANCER PREV RES, V4, P486, DOI 10.1158/1940-6207.CAPR-10-0229
   Chavarro JE, 2010, FERTIL STERIL, V93, P2222, DOI 10.1016/j.fertnstert.2009.01.100
   Collado R, 2012, CANCER LETT, V317, P144, DOI 10.1016/j.canlet.2011.11.018
   Cust AE, 2007, INT J CANCER, V120, P2656, DOI 10.1002/ijc.22578
   D'Archivio M, 2012, EUR J CLIN INVEST, V42, P70, DOI 10.1111/j.1365-2362.2011.02558.x
   Daling JR, 2001, CANCER, V92, P720, DOI 10.1002/1097-0142(20010815)92:4<720::AID-CNCR1375>3.0.CO;2-T
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   de Onis M, 2007, B WORLD HEALTH ORGAN, V85, P660, DOI 10.2471/BLT.07.043497
   De Pergola G, 2013, J OBES, V2013, DOI 10.1155/2013/291546
   Ríspoli LD, 2013, NUTR HOSP, V28, P1085, DOI 10.3305/nh.2013.28.4.6539
   Ríspoli LD, 2013, NUTR HOSP, V28, P671, DOI 10.3305/nh.2013.28.3.6355
   Demark-Wahnefried W, 2012, CANCER EPIDEM BIOMAR, V21, P1244, DOI 10.1158/1055-9965.EPI-12-0485
   Diaz-Meco MT, 2012, IMMUNOL REV, V246, P154, DOI 10.1111/j.1600-065X.2012.01093.x
   Dieudonne MN, 2006, BIOCHEM BIOPH RES CO, V345, P271, DOI 10.1016/j.bbrc.2006.04.076
   Dieudonne MN, 2002, BIOCHEM BIOPH RES CO, V293, P622, DOI 10.1016/S0006-291X(02)00205-X
   Dröse S, 2012, ADV EXP MED BIOL, V748, P145, DOI 10.1007/978-1-4614-3573-0_6
   Dupont C, 2013, ASIAN J ANDROL, V15, P622, DOI 10.1038/aja.2013.65
   Ewertz M, 2011, J CLIN ONCOL, V29, P25, DOI 10.1200/JCO.2010.29.7614
   Fandos M, 2009, FREE RADICAL RES, V43, P1179, DOI 10.3109/10715760903247231
   Ferré N, 2013, CLIN BIOCHEM, V46, P1830, DOI 10.1016/j.clinbiochem.2013.08.020
   Ferretti G, 2010, OBESITY, V18, P1079, DOI 10.1038/oby.2009.338
   Flegal KM, 2010, JAMA-J AM MED ASSOC, V303, P235, DOI 10.1001/jama.2009.2014
   Frystyk J, 2004, GROWTH HORM IGF RES, V14, P337, DOI 10.1016/j.ghir.2004.06.001
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   García-Heredia A, 2013, J PROTEOME RES, V12, P1946, DOI 10.1021/pr400050u
   GIOVANNUCCI E, 1995, CANCER CAUSE CONTROL, V6, P164, DOI 10.1007/BF00052777
   Goktas S, 2005, UROLOGY, V65, P1168, DOI 10.1016/j.urology.2004.12.053
   Halliwell B., 2000, FREE RADICAL BIO MED, V3rd
   Hardwick JCH, 2001, GASTROENTEROLOGY, V121, P79, DOI 10.1053/gast.2001.25490
   Haslam D, 2007, OBES REV, V8, P31, DOI 10.1111/j.1467-789X.2007.00314.x
   Héron-Milhavet L, 2002, J BIOL CHEM, V277, P15600, DOI 10.1074/jbc.M111142200
   Heydari AR, 2007, NUCLEIC ACIDS RES, V35, P7485, DOI 10.1093/nar/gkm860
   Hsing AW, 2007, AM J CLIN NUTR, V86, p843S, DOI 10.1093/ajcn/86.3.843S
   Il'yasova D, 2012, OBESITY, V20, P1915, DOI 10.1038/oby.2011.292
   Itoh K, 1997, BIOCHEM BIOPH RES CO, V236, P313, DOI 10.1006/bbrc.1997.6943
   Kanaya AM, 2011, OBESITY, V19, P861, DOI 10.1038/oby.2010.243
   Klungland A, 1999, P NATL ACAD SCI USA, V96, P13300, DOI 10.1073/pnas.96.23.13300
   Krzystek-Korpacka M, 2013, ADV CLIN EXP MED, V22, P229
   KUCHINO Y, 1987, NATURE, V327, P77, DOI 10.1038/327077a0
   Lagunova Z, 2010, MOL NUTR FOOD RES, V54, P1127, DOI 10.1002/mnfr.200900512
   Lichtman MA, 2010, ONCOLOGIST, V15, P1083, DOI 10.1634/theoncologist.2010-0206
   Lobstein T, 2003, Obes Rev, V4, P195, DOI 10.1046/j.1467-789X.2003.00116.x
   Loft S, 2012, ARCH BIOCHEM BIOPHYS, V518, P142, DOI 10.1016/j.abb.2011.12.026
   López-Uriarte P, 2010, CLIN NUTR, V29, P373, DOI 10.1016/j.clnu.2009.12.008
   Martinez-Hervas S, 2008, ATHEROSCLEROSIS, V199, P384, DOI 10.1016/j.atherosclerosis.2007.11.023
   MCKEOWNEYSSEN G, 1994, CANCER EPIDEM BIOMAR, V3, P687
   McMillan DC, 2006, BRIT MED J, V333, P1109, DOI 10.1136/bmj.39042.565035.BE1
   Milic M, 2013, MUTAT RES-GEN TOX EN, V758, P1, DOI 10.1016/j.mrgentox.2013.07.013
   Miyoshi Y, 2003, CLIN CANCER RES, V9, P5699
   Oliva MR, 1997, MOL CARCINOGEN, V18, P232, DOI 10.1002/(SICI)1098-2744(199704)18:4<232::AID-MC7>3.3.CO;2-5
   Oltra AM, 2001, FREE RADICAL BIO MED, V30, P1286, DOI 10.1016/S0891-5849(01)00521-4
   Pallavi R, 2012, FRONT PHYSIOL, V3, P1
   Patel C, 2007, J CLIN ENDOCR METAB, V92, P4476, DOI 10.1210/jc.2007-0778
   Petridou E, 2003, J CLIN ENDOCR METAB, V88, P993, DOI 10.1210/jc.2002-021209
   Pisani Paola, 2008, Archives of Physiology and Biochemistry, V114, P63, DOI [10.1080/13813450801954451, 10.1080/13813450801954451 ]
   Pollak MN, 2004, NAT REV CANCER, V4, P505, DOI 10.1038/nrc1387
   Protani M, 2010, BREAST CANCER RES TR, V123, P627, DOI 10.1007/s10549-010-0990-0
   Real JT, 2010, METABOLISM, V59, P293, DOI 10.1016/j.metabol.2009.07.026
   Reeves GK, 2007, BRIT MED J, V335, P1134, DOI 10.1136/bmj.39367.495995.AE
   Renehan AG, 2008, LANCET, V371, P569, DOI 10.1016/S0140-6736(08)60269-X
   Renehan AG, 2006, TRENDS ENDOCRIN MET, V17, P328, DOI 10.1016/j.tem.2006.08.006
   Ricart W, 2001, OBES RES, V9, P631, DOI 10.1038/oby.2001.83
   Rindler PM, 2013, J BIOL CHEM, V288, P1979, DOI 10.1074/jbc.M112.412890
   Roberts DL, 2010, ANNU REV MED, V61, P301, DOI 10.1146/annurev.med.080708.082713
   Rose D P, 2004, Obes Rev, V5, P153, DOI 10.1111/j.1467-789X.2004.00142.x
   Sampath H, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051697
   Sanchez M, 2006, CANCER LETT, V233, P28, DOI 10.1016/j.canlet.2005.02.036
   Sánchez-Cruz JJ, 2013, REV ESP CARDIOL, V66, P371, DOI [10.1016/j.rec.2012.10.012, 10.1016/j.recesp.2012.10.016]
   Savini I, 2013, INT J MOL SCI, V14, P10497, DOI 10.3390/ijms140510497
   SHIBUTANI S, 1991, NATURE, V349, P431, DOI 10.1038/349431a0
   Shin S, 2009, EUR J PHARMACOL, V620, P138, DOI 10.1016/j.ejphar.2009.08.022
   SIES H, 1985, PHILOS T ROY SOC B, V311, P617, DOI 10.1098/rstb.1985.0168
   Sinicrope FA, 2010, CLIN CANCER RES, V16, P1884, DOI 10.1158/1078-0432.CCR-09-2636
   Spindler SR, 2005, MECH AGEING DEV, V126, P960, DOI 10.1016/j.mad.2005.03.016
   Surmi BK, 2010, VASC PHARMACOL, V52, P27, DOI 10.1016/j.vph.2009.12.004
   Mitjavila MT, 2013, CLIN NUTR, V32, P172, DOI 10.1016/j.clnu.2012.08.002
   Verheus M, 2006, INT J CANCER, V119, P659, DOI 10.1002/ijc.21861
   Wang Y, 2006, INT J PEDIATR OBES, V1, P11, DOI 10.1080/17477160600586747
   Wei EK, 2005, JNCI-J NATL CANCER I, V97, P1688, DOI 10.1093/jnci/dji376
   Wolin KY, 2010, ONCOLOGIST, V15, P556, DOI 10.1634/theoncologist.2009-0285
   Wu YP, 2002, CANCER RES, V62, P1030
   Zhang HH, 2011, AM J PATHOL, V178, P1715, DOI 10.1016/j.ajpath.2010.12.038
NR 97
TC 48
Z9 52
U1 0
U2 16
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 0065-2598
EI 2214-8019
BN 978-3-319-07320-0; 978-3-319-07319-4
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2014
VL 824
BP 5
EP 17
DI 10.1007/978-3-319-07320-0_2
D2 10.1007/978-3-319-07320-0
PG 13
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pathology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pathology
GA BB8GE
UT WOS:000346519700002
PM 25038989
DA 2025-06-11
ER

PT J
AU Molinar-Toribio, E
   Pérez-Jiménez, J
   Ramos-Romero, S
   Lluís, L
   Sánchez-Martos, V
   Taltavull, N
   Romeu, M
   Pazos, M
   Méndez, L
   Miranda, A
   Cascante, M
   Medina, I
   Torres, JL
AF Molinar-Toribio, Eunice
   Perez-Jimenez, Jara
   Ramos-Romero, Sara
   Lluis, Laura
   Sanchez-Martos, Vanessa
   Taltavull, Nuria
   Romeu, Marta
   Pazos, Manuel
   Mendez, Lucia
   Miranda, Anibal
   Cascante, Marta
   Medina, Isabel
   Lluis Torres, Josep
TI Cardiovascular Disease-Related Parameters and Oxidative Stress in SHROB
   Rats, a Model for Metabolic Syndrome
SO PLOS ONE
LA English
DT Article
ID MESENTERIC RESISTANCE ARTERIES; INSULIN-RESISTANCE; NONSENSE MUTATION;
   LEPTIN RECEPTOR; KOLETSKY RATS; PROTEIN; FAT; INFLAMMATION; GLUTATHIONE;
   CATALASE
AB SHROB rats have been suggested as a model for metabolic syndrome (MetS) as a situation prior to the onset of CVD or type-2 diabetes, but information on descriptive biochemical parameters for this model is limited. Here, we extensively evaluate parameters related to CVD and oxidative stress (OS) in SHROB rats. SHROB rats were monitored for 15 weeks and compared to a control group of Wistar rats. Body weight was recorded weekly. At the end of the study, parameters related to CVD and OS were evaluated in plasma, urine and different organs. SHROB rats presented statistically significant differences from Wistar rats in CVD risk factors: total cholesterol, LDL-cholesterol, triglycerides, apoA1, apoB100, abdominal fat, insulin, blood pressure, C-reactive protein, ICAM-1 and PAI-1. In adipose tissue, liver and brain, the endogenous antioxidant systems were activated, yet there was no significant oxidative damage to lipids (MDA) or proteins (carbonylation). We conclude that SHROB rats present significant alterations in parameters related to inflammation, endothelial dysfunction, thrombotic activity, insulin resistance and OS measured in plasma as well as enhanced redox defence systems in vital organs that will be useful as markers of MetS and CVD for nutrition interventions.
C1 [Molinar-Toribio, Eunice; Perez-Jimenez, Jara; Ramos-Romero, Sara; Lluis Torres, Josep] CSIC, IQAC, Inst Adv Chem Catalonia, Barcelona, Spain.
   [Ramos-Romero, Sara] CIBER BBN, Biomed Res Networking Ctr Bioengn Biomat & Nanome, Zaragoza, Spain.
   [Lluis, Laura; Sanchez-Martos, Vanessa; Taltavull, Nuria; Romeu, Marta] Univ Rovira & Virgili, Fac Med & Ciencias Salut, Unidad Farmacol, E-43201 Reus, Spain.
   [Pazos, Manuel; Mendez, Lucia; Medina, Isabel] CSIC, IIM, Vigo, Spain.
   [Miranda, Anibal; Cascante, Marta] Univ Barcelona, Fac Biol, IBUB, Dept Biochem & Mol Biol, Barcelona, Spain.
   [Miranda, Anibal; Cascante, Marta] Univ Barcelona, Fac Biol, Unit Associated CSIC, Barcelona, Spain.
   [Miranda, Anibal; Cascante, Marta] Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro de
   Investigacion y Desarrollo Pascual Vila (CID-CSIC); CSIC - Instituto de
   Quimica Avanzada de Cataluna (IQAC); CIBER - Centro de Investigacion
   Biomedica en Red; CIBERBBN; Universitat Rovira i Virgili; Consejo
   Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de
   Investigaciones Marinas (IIM); University of Barcelona; University of
   Barcelona; Consejo Superior de Investigaciones Cientificas (CSIC);
   University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS
RP Pérez-Jiménez, J (corresponding author), CSIC, IQAC, Inst Adv Chem Catalonia, Barcelona, Spain.
EM jara.perez@ictan.csic.es
RI CASCANTE, MARTA/AFK-5991-2022; ROMEU, MARTA/O-7129-2019; Ramos-Romero,
   Sara/AAH-6209-2020; MEDINA, ISABEL/AAL-4012-2021; Perez-Jimenez,
   Jara/B-3989-2009; Torres, Josep/N-7256-2013; Pazos, Manuel/N-5007-2014;
   Ramos-Romero, Sara/K-8301-2017; Mendez, Lucia/T-7016-2017; ROMEU,
   MARTA/A-8468-2014
OI Torres, Josep/0000-0002-5072-8265; Molinar-Toribio,
   Eunice/0000-0001-8870-6849; Pazos, Manuel/0000-0003-1571-5730; MEDINA,
   ISABEL/0000-0002-1854-3359; Ramos-Romero, Sara/0000-0002-9293-4454;
   Taltavull, Nuria/0000-0002-3340-2650; Mendez, Lucia/0000-0002-9711-2994;
   CASCANTE, MARTA/0000-0002-2062-4633; ROMEU, MARTA/0000-0002-2131-1858;
   Perez-Jimenez, Jara/0000-0002-2811-4558
FU Spanish Ministries of Science and Innovation and of Economy and
   Competitiveness [AGL2009-12374-C03-01, AGL2009-12374-C03-02,
   AGL2009-12374-C03-03, AGL2013-49079-C2-1-R, AGL2013-49079-C2-2-R];
   Generalitat de Catalunya regional authorities [2009SGR-1308]; European
   Union [FP7-KBBE-222639]; ICREA Foundation of the Generalitat de
   Catalunya; Panamanian Government (SENACYT/IFRHU); Spanish Ministry of
   Science and Innovation; ISCIII; Xunta de Galicia [CD09/00068]
FX This research was supported by the Spanish Ministries of Science and
   Innovation and of Economy and Competitiveness (Grants
   AGL2009-12374-C03-01, -02 and -03; AGL2013-49079-C2-1,2-R; respectively)
   and in part by the Generalitat de Catalunya regional authorities
   (2009SGR-1308). M. C. acknowledges ETHERPATHS (FP7-KBBE-222639) funded
   by the European Union and "ICREA Academia'' award for excellence in
   research, funded by the ICREA Foundation of the Generalitat de
   Catalunya. The Panamanian Government (SENACYT/IFRHU) and the Spanish
   Ministry of Science and Innovation awarded graduate fellowships to E.
   M.-T. and L. M., respectively. The ISCIII and the Xunta de Galicia are
   also acknowledged for "Sara Borrell'' and "Isidro Parga Pondal''
   postdoctoral contracts to J.P.-J. (CD09/00068) and M. P., respectively.
   The funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Armutcu F, 2008, CLIN CHEM LAB MED, V46, P785, DOI 10.1515/CCLM.2008.166
   BENJAMINI Y, 1995, J R STAT SOC B, V57, P289, DOI 10.1111/j.2517-6161.1995.tb02031.x
   Bergmeyer HU., 1983, METHODS ENZYMATIC AN, VVI., P258, DOI [10.1016/B978-0-12-091302-2.X5001-4, DOI 10.1016/B978-0-12-091302-2.X5001-4]
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Buege J A, 1978, Methods Enzymol, V52, P302
   BUNAG RD, 1973, J APPL PHYSIOL, V34, P279, DOI 10.1152/jappl.1973.34.2.279
   Cao GH, 1998, AM J CLIN NUTR, V68, P1081, DOI 10.1093/ajcn/68.5.1081
   Castell-Auví A, 2012, J NUTR BIOCHEM, V23, P1565, DOI 10.1016/j.jnutbio.2011.10.010
   Chaudhuri AR, 2006, MECH AGEING DEV, V127, P849, DOI 10.1016/j.mad.2006.08.006
   Chawla A, 2011, NAT REV IMMUNOL, V11, P738, DOI 10.1038/nri3071
   Chua SC, 1996, SCIENCE, V271, P994, DOI 10.1126/science.271.5251.994
   COHEN G, 1970, ANAL BIOCHEM, V34, P30, DOI 10.1016/0003-2697(70)90083-7
   Drabkin DL, 1935, J BIOL CHEM, V112, P51
   Eckel RH, 2010, LANCET, V375, P181, DOI 10.1016/S0140-6736(09)61794-3
   Ernsberger P, 1999, ANN NY ACAD SCI, V892, P315, DOI 10.1111/j.1749-6632.1999.tb07806.x
   Ernsberger P, 2012, GLUCOSE TOLERANCE
   Fellmann L, 2013, PHARMACOL THERAPEUT, V137, P331, DOI 10.1016/j.pharmthera.2012.11.004
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Güçlü F, 2004, BIOMED PHARMACOTHER, V58, P614, DOI 10.1016/j.biopha.2004.09.005
   Hariri N, 2010, NUTR RES REV, V23, P270, DOI 10.1017/S0954422410000168
   HISSIN PJ, 1976, ANAL BIOCHEM, V74, P214, DOI 10.1016/0003-2697(76)90326-2
   Imig JD, 2012, EXP BIOL MED, V237, P1402, DOI 10.1258/ebm.2012.012225
   Ishizuka T, 1998, J NUTR, V128, P2299, DOI 10.1093/jn/128.12.2299
   Kimura T, 2007, J AGR FOOD CHEM, V55, P5869, DOI 10.1021/jf062680g
   KOLETSKY S, 1973, EXP MOL PATHOL, V19, P53, DOI 10.1016/0014-4800(73)90040-3
   KOLETSKY S, 1975, AM J PATHOL, V81, P463
   LAEMMLI UK, 1970, NATURE, V227, P680, DOI 10.1038/227680a0
   Maritim AC, 2003, J BIOCHEM MOL TOXIC, V17, P24, DOI 10.1002/jbt.10058
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Méndez L, 2014, J PROTEOMICS, V106, P246, DOI 10.1016/j.jprot.2014.04.036
   Méndez L, 2013, FREE RADICAL BIO MED, V55, P8, DOI 10.1016/j.freeradbiomed.2012.11.004
   Mendizábal Y, 2013, LIFE SCI, V93, P1023, DOI 10.1016/j.lfs.2013.10.021
   Mendizábal Y, 2011, AM J PHYSIOL-HEART C, V301, pH1319, DOI 10.1152/ajpheart.01280.2010
   Milne GL, 2007, NAT PROTOC, V2, P221, DOI 10.1038/nprot.2006.375
   MISRA HP, 1972, J BIOL CHEM, V247, P3170
   Papazzo A, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-98
   Poudyal H, 2010, BRIT J NUTR, V104, P1322, DOI 10.1017/S0007114510002308
   Samuel VT, 2012, CELL, V148, P852, DOI 10.1016/j.cell.2012.02.017
   SIMES RJ, 1986, BIOMETRIKA, V73, P751, DOI 10.2307/2336545
   Takaya K, 1996, NAT GENET, V14, P130, DOI 10.1038/ng1096-130
   WHEELER CR, 1990, ANAL BIOCHEM, V184, P193, DOI 10.1016/0003-2697(90)90668-Y
   Zhang BB, 2009, CELL METAB, V9, P407, DOI 10.1016/j.cmet.2009.03.012
NR 44
TC 16
Z9 16
U1 0
U2 19
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 12
PY 2014
VL 9
IS 8
AR e104637
DI 10.1371/journal.pone.0104637
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AO3LJ
UT WOS:000341230400064
PM 25115868
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wong, SK
AF Wong, Sok Kuan
TI Repurposing New Use for Old Drug Chloroquine against Metabolic Syndrome:
   A Review on Animal and Human Evidence
SO INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
LA English
DT Review
DE diabetes; dyslipidaemia; hypertension; immunomodulation; inflammation;
   obesity
ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; TYPE-2 DIABETES-MELLITUS;
   RHEUMATOID-ARTHRITIS; ENDOTHELIAL DYSFUNCTION; HYDROXYCHLOROQUINE USE;
   INSULIN SENSITIVITY; VIRUS-REPLICATION; LIPID PROFILE; DOUBLE-BLIND;
   RISK
AB Chloroquine (CQ) and hydroxychloroquine (HCQ) are traditional anti-malarial drugs that have been repurposed for new therapeutic uses in many diseases due to their simple usage and cost-effectiveness. The pleiotropic effects of CQ and HCQ in regulating blood pressure, glucose homeostasis, lipid, and carbohydrate metabolism have been previously described in vivo and in humans, thus suggesting their role in metabolic syndrome (MetS) prevention. The anti-hyperglycaemic, anti-hyperlipidaemic, cardioprotective, anti-hypertensive, and anti-obesity effects of CQ and HCQ might be elicited through reduction of inflammatory response and oxidative stress, improvement of endothelial function, activation of insulin signalling pathway, inhibition of lipogenesis and autophagy, as well as regulation of adipokines and apoptosis. In conclusion, the current state of knowledge supported the repurposing of CQ and HCQ usage in the management of MetS.
C1 [Wong, Sok Kuan] Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
C3 Universiti Kebangsaan Malaysia
RP Wong, SK (corresponding author), Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
EM jocylnwsk@gmail.com
RI Wong, Sok/I-1243-2016
FU Universiti Kebangsaan Malaysia [FF-2020-366]
FX The author would like to thank Universiti Kebangsaan Malaysia for the
   support via FF-2020-366 grant.
CR Abdel-Hamid AAM, 2016, ACTA HISTOCHEM, V118, P560, DOI 10.1016/j.acthis.2016.06.002
   Abdel-Hamid AAM, 2016, J MOL HISTOL, V47, P183, DOI 10.1007/s10735-016-9664-5
   Abushahla HS, 2019, INT J DIABETES DEV C, V39, P82, DOI 10.1007/s13410-018-0654-x
   Angelakis E, 2014, ANTIMICROB AGENTS CH, V58, P3342, DOI 10.1128/AAC.02437-14
   Arnaout A, 2019, BREAST CANCER RES TR, V178, P327, DOI 10.1007/s10549-019-05381-y
   ASAMOAH KA, 1989, CLIN SCI, V76, P137, DOI 10.1042/cs0760137
   Baker JF, 2018, JCR-J CLIN RHEUMATOL, V24, P203, DOI 10.1097/RHU.0000000000000736
   Garrido JADB, 2016, MED CLIN-BARCELONA, V147, P63, DOI 10.1016/j.medcli.2016.03.030
   Bellomio V, 2009, LUPUS, V18, P1019, DOI 10.1177/0961203309105876
   Bhusal A, 2019, BIOCHEM PHARMACOL, V169, DOI 10.1016/j.bcp.2019.113626
   Bili A, 2011, JCR-J CLIN RHEUMATOL, V17, P115, DOI 10.1097/RHU.0b013e318214b6b5
   Blignaut M, 2019, CARDIOVASC DRUG THER, V33, P1, DOI 10.1007/s10557-018-06847-9
   Boucher J, 2014, CSH PERSPECT BIOL, V6, DOI 10.1101/cshperspect.a009191
   Cairoli E, 2012, LUPUS, V21, P1178, DOI 10.1177/0961203312450084
   Charles-Schoeman C, 2017, ARTHRITIS RHEUMATOL, V69, P46, DOI 10.1002/art.39833
   Charles-Schoeman C, 2016, ARTHRITIS RHEUMATOL, V68, P577, DOI 10.1002/art.39502
   Chen FX, 2010, J PEDIATR ENDOCR MET, V23, P709
   Chen Y, 2020, FRONT PHARMACOL, V11
   Chen YM, 2015, RHEUMATOLOGY, V54, P1244, DOI 10.1093/rheumatology/keu451
   Chung CP, 2008, ATHEROSCLEROSIS, V196, P756, DOI 10.1016/j.atherosclerosis.2007.01.004
   Cortegiani A, 2020, J CRIT CARE, V57, P279, DOI 10.1016/j.jcrc.2020.03.005
   Costa FF, 2020, DIAB MET SYND CLIN R, V14, P809, DOI 10.1016/j.dsx.2020.06.016
   Lima TLC, 2018, PHARMACEUTICS, V10, DOI 10.3390/pharmaceutics10040255
   Desai RJ, 2015, ARTHRIT CARE RES, V67, P457, DOI 10.1002/acr.22483
   Devaux Christian A, 2020, Int J Antimicrob Agents, V55, P105938, DOI 10.1016/j.ijantimicag.2020.105938
   Neto ETD, 2020, ADV RHEUMATOL, V60
   Emami J, 1999, CAN J PHYSIOL PHARM, V77, P118, DOI 10.1139/cjpp-77-2-118
   Erum U, 2017, PAK J MED SCI, V33, P227, DOI 10.12669/pjms.331.11699
   Gerstein HC, 2002, DIABETES RES CLIN PR, V55, P209, DOI 10.1016/S0168-8227(01)00325-4
   Girard CAJ, 2006, PFLUG ARCH EUR J PHY, V453, P323, DOI 10.1007/s00424-006-0112-3
   Glick D, 2010, J PATHOL, V221, P3, DOI 10.1002/path.2697
   Gonzalez Fatima E Murillo, 2019, Arch Med Sci Atheroscler Dis, V4, pe47, DOI 10.5114/amsad.2019.84447
   Graham ML, 2011, COMPARATIVE MED, V61, P356
   Halaby MJ, 2013, BIOCHEM BIOPH RES CO, V435, P708, DOI 10.1016/j.bbrc.2013.05.047
   Haladyj Ewa, 2018, Reumatologia (Warsaw), V56, P164, DOI 10.5114/reum.2018.76904
   Hallajzadeh J, 2018, LUPUS, V27, P899, DOI 10.1177/0961203317751047
   da Mota LMH, 2013, REV BRAS REUMATOL, V53, P158, DOI 10.1016/S2255-5021(13)70020-8
   Hong M, 2012, J BIOL CHEM, V287, P41258, DOI 10.1074/jbc.M112.412122
   Hsia SH, 2020, J DIABETES, V12, P91, DOI 10.1111/1753-0407.12989
   Ighodaro OM, 2017, MEDICINA-LITHUANIA, V53, P365, DOI 10.1016/j.medici.2018.02.001
   Jorge A, 2018, NAT REV RHEUMATOL, V14, P693, DOI 10.1038/s41584-018-0111-8
   Karalis V, 2020, SAFETY SCI, V129, DOI 10.1016/j.ssci.2020.104842
   Kavanaugh A, 1997, J Clin Rheumatol, V3, P3, DOI 10.1097/00124743-199702000-00002
   Kerr G, 2014, ARTHRIT CARE RES, V66, P1619, DOI 10.1002/acr.22341
   Khan M, 2010, J MED VIROL, V82, P817, DOI 10.1002/jmv.21663
   KRONENBERGER P, 1991, J VIROL, V65, P7008, DOI 10.1128/JVI.65.12.7008-7011.1991
   Long L, 2013, CIRC RES, V112, P1159, DOI 10.1161/CIRCRESAHA.111.300483
   Loreto C, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/616149
   Macfarlane WM, 2000, DIABETES, V49, P953, DOI 10.2337/diabetes.49.6.953
   Makni E, 2013, OBESITY FACTS, V6, P393, DOI 10.1159/000354574
   Mangaraj M, 2016, INDIAN J CLIN BIOCHE, V31, P253, DOI 10.1007/s12291-015-0513-1
   Masui Y, 2019, J ENDOCRINOL METAB, V9, P159, DOI 10.14740/jem611
   McCarthy CG, 2017, AM J HYPERTENS, V30, P173, DOI 10.1093/ajh/hpw113
   McCarthy CG, 2016, PHARMACOL RES, V113, P384, DOI 10.1016/j.phrs.2016.09.008
   McGill JB, 2019, DIABETOL METAB SYNDR, V11, DOI 10.1186/s13098-019-0456-4
   Mercer E, 2012, ARTHRITIS RES THER, V14, DOI 10.1186/ar3868
   Migkos MP, 2014, J RHEUMATOL, V41, P902, DOI 10.3899/jrheum.131156
   Mizui T, 2010, J GASTROENTEROL, V45, P195, DOI 10.1007/s00535-009-0132-9
   Morris SJ, 2011, ARTHRIT CARE RES, V63, P530, DOI 10.1002/acr.20393
   Ntaios G, 2013, ATHEROSCLEROSIS, V227, P216, DOI 10.1016/j.atherosclerosis.2012.12.029
   NWOHA PU, 1995, CONTRACEPTION, V52, P261, DOI 10.1016/0010-7824(95)00186-E
   Pareek A, 2015, CURR MED RES OPIN, V31, P2105, DOI 10.1185/03007995.2015.1087989
   Pareek A, 2014, CURR MED RES OPIN, V30, P1257, DOI 10.1185/03007995.2014.909393
   Pareek A, 2009, INDIAN J PHARMACOL, V41, P125, DOI 10.4103/0253-7613.55213
   Penn SK, 2010, J RHEUMATOL, V37, P1136, DOI 10.3899/jrheum.090994
   de Sena LWP, 2019, MALARIA J, V18, DOI 10.1186/s12936-019-3072-8
   Ponce-Balbuena D, 2012, MOL PHARMACOL, V82, P803, DOI 10.1124/mol.112.079152
   POWRIE JK, 1993, METABOLISM, V42, P415, DOI 10.1016/0026-0495(93)90096-7
   POWRIE JK, 1991, AM J PHYSIOL, V260, pE897, DOI 10.1152/ajpendo.1991.260.6.E897
   Qiao X, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.00855
   Ramos-Casals M, 2007, J RHEUMATOL, V34, P754
   Rekedal LR, 2010, ARTHRITIS RHEUM-US, V62, P3569, DOI 10.1002/art.27703
   Restrepo JF, 2017, JCR-J CLIN RHEUMATOL, V23, P144, DOI 10.1097/RHU.0000000000000502
   Rossoni C, 2011, REV BRAS REUMATOL, V51, P383
   Savarino A, 2001, AIDS, V15, P2221, DOI 10.1097/00002030-200111230-00002
   Schrezenmeier E, 2020, NAT REV RHEUMATOL, V16, P155, DOI 10.1038/s41584-020-0372-x
   SEIDEMAN P, 1994, ARTHRITIS RHEUM, V37, P830, DOI 10.1002/art.1780370609
   Sheikhbahaie Fahimeh, 2016, Adv Biomed Res, V5, P145, DOI 10.4103/2277-9175.187401
   Shiryaev SA, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-15467-6
   Farias KJS, 2014, MICROBIOL IMMUNOL, V58, P318, DOI 10.1111/1348-0421.12154
   Smit C, 2020, CLIN PHARMACOKINET, V59, P659, DOI 10.1007/s40262-020-00891-1
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Solomon DH, 2014, ARTHRIT CARE RES, V66, P1246, DOI 10.1002/acr.22285
   Sparrenberger K, 2019, DIABETOL METAB SYNDR, V11, DOI 10.1186/s13098-019-0435-9
   Srinivasa Amar, 2017, J Rheumatol, V44, P398, DOI 10.3899/jrheum.161063
   Sullivan DJ, 1996, P NATL ACAD SCI USA, V93, P11865, DOI 10.1073/pnas.93.21.11865
   Tam LS, 2000, LUPUS, V9, P413, DOI 10.1191/096120300678828541
   Thatoi PK, 2018, DIABETES, V67, DOI 10.2337/db18-2388-PUB
   Theengh DP, 2017, INDIAN J SEX TRANSM, V38, P152, DOI 10.4103/ijstd.IJSTD_55_16
   Thomzig A, 2005, J COMP NEUROL, V484, P313, DOI 10.1002/cne.20469
   Tricou Vianney, 2010, PLoS Negl Trop Dis, V4, pe785, DOI 10.1371/journal.pntd.0000785
   TSIANG H, 1984, ARCH VIROL, V81, P377, DOI 10.1007/BF01310010
   Ursing J, 2020, ANTIMICROB AGENTS CH, V64, DOI 10.1128/AAC.01846-19
   Valenzuela R, 2011, FOOD FUNCT, V2, P644, DOI 10.1039/c1fo10133a
   Virdis A, 2007, HYPERTENSION, V49, P679, DOI 10.1161/01.HYP.0000253085.56217.11
   Wang BX, 2014, CURR DIABETES REV, V10, P131, DOI 10.2174/1573399810666140508121012
   Wang LH, 2017, TZU CHI MED J, V29, P159, DOI 10.4103/tcmj.tcmj_60_17
   Wang R, 2017, J PHARMACOL EXP THER, V361, P29, DOI 10.1124/jpet.116.239087
   Wasko MCM, 2015, DIABETOLOGIA, V58, P2336, DOI 10.1007/s00125-015-3689-2
   Wiwanitkit V., 2015, J NEPHROPHARMACOL, V5, P11
   Wong SK, 2019, SAINS MALAYS, V48, P2701, DOI 10.17576/jsm-2019-4812-11
   Wong SK, 2019, CURR DRUG TARGETS, V20, P1264, DOI 10.2174/1389450120666190405172524
   World Health Organization, 2015, Guidelines for the treatment of Malaria-Third edition
   Wu K, 2017, BRIT J PHARMACOL, V174, P4155, DOI 10.1111/bph.13990
   Wyss K, 2017, CLIN INFECT DIS, V65, P949, DOI 10.1093/cid/cix437
   Yan YW, 2013, CELL RES, V23, P300, DOI 10.1038/cr.2012.165
   Yu JH, 2015, BIOCHEM BIOPH RES CO, V460, P715, DOI 10.1016/j.bbrc.2015.03.095
   Yuan JS, 2016, BIOMED REP, V4, P68, DOI 10.3892/br.2015.544
   Yuan X, 2016, DRUG DES DEV THER, V10, P2729, DOI 10.2147/DDDT.S111253
   Zhang XT, 2021, ASIA PAC J TOUR RES, V26, P147, DOI 10.1080/10941665.2020.1718171
NR 110
TC 20
Z9 21
U1 0
U2 5
PU IVYSPRING INT PUBL
PI LAKE HAVEN
PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
SN 1449-1907
J9 INT J MED SCI
JI Int. J. Med. Sci.
PY 2021
VL 18
IS 12
BP 2673
EP 2688
DI 10.7150/ijms.58147
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA TD0CW
UT WOS:000669005200004
PM 34104100
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kant, S
   Standen, CL
   Morel, C
   Jung, DY
   Kim, JK
   Swat, W
   Flavell, RA
   Davis, RJ
AF Kant, Shashi
   Standen, Claire L.
   Morel, Caroline
   Jung, Dae Young
   Kim, Jason K.
   Swat, Wojciech
   Flavell, Richard A.
   Davis, Roger J.
TI A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response
   to Metabolic Stress
SO CELL REPORTS
LA English
DT Article
ID MAP KINASE ACTIVATION; SIGNAL-TRANSDUCTION; INSULIN-RESISTANCE; FAMILY
   KINASES; ADIPOSE-TISSUE; PATHWAY; OBESITY; REQUIREMENT; VAV;
   IDENTIFICATION
AB Obesity is a major risk factor for the development of metabolic syndrome and type 2 diabetes. How obesity contributes to metabolic syndrome is unclear. Free fatty acid (FFA) activation of a non-receptor tyrosine kinase (SRC)-dependent cJun NH2-terminal kinase (JNK) signaling pathway is implicated in this process. However, the mechanism that mediates SRC-dependent JNK activation is unclear. Here, we identify a role for the scaffold protein JIP1 in SRC-dependent JNK activation. SRC phosphorylation of JIP1 creates phosphotyrosine interaction motifs that bind the SH2 domains of SRC and the guanine nucleotide exchange factor VAV. These interactions are required for SRC-induced activation of VAV and the subsequent engagement of a JIP1-tethered JNK signaling module. The JIP1 scaffold protein, therefore, plays a dual role in FFA signaling by coordinating upstream SRC functions together with downstream effector signaling by the JNK pathway.
C1 [Kant, Shashi; Standen, Claire L.; Morel, Caroline; Jung, Dae Young; Kim, Jason K.; Davis, Roger J.] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA.
   [Kant, Shashi] Univ Massachusetts, Sch Med, Dept Med, Div Cardiovasc Med, Worcester, MA 01605 USA.
   [Kim, Jason K.] Univ Massachusetts, Sch Med, Dept Med, Div Endocrinol Metab & Diabet, Worcester, MA 01605 USA.
   [Swat, Wojciech] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA.
   [Flavell, Richard A.] Yale Univ, Sch Med, Howard Hughes Med Inst, 333 Cedar St, New Haven, CT 06520 USA.
   [Flavell, Richard A.] Yale Univ, Sch Med, Dept Immunobiol, 333 Cedar St, New Haven, CT 06520 USA.
   [Davis, Roger J.] Howard Hughes Med Inst, Worcester, MA 01605 USA.
C3 University of Massachusetts System; University of Massachusetts
   Worcester; University of Massachusetts System; University of
   Massachusetts Worcester; University of Massachusetts System; University
   of Massachusetts Worcester; Washington University (WUSTL); Howard Hughes
   Medical Institute; Yale University; Yale University; Howard Hughes
   Medical Institute
RP Kant, S; Davis, RJ (corresponding author), Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA.; Kant, S (corresponding author), Univ Massachusetts, Sch Med, Dept Med, Div Cardiovasc Med, Worcester, MA 01605 USA.; Davis, RJ (corresponding author), Howard Hughes Med Inst, Worcester, MA 01605 USA.
EM shashi.kant@umassmed.edu; roger.davis@umassmed.edu
RI Flavell, Richard/ACH-3245-2022; Kant, Shashi/B-1585-2016
OI Davis, Roger/0000-0002-0130-1652; Kant, Shashi/0000-0001-8772-6813; Kim,
   Jason/0000-0002-7185-042X
FU NIH [DK107220, DK112698, DK093000]; American Heart Association
   [16SDG29660007]; American Heart Association (AHA) [16SDG29660007]
   Funding Source: American Heart Association (AHA)
FX We thank Vicky Benoit and Heather Learnard for expert technical
   assistance and Kathy Gemme for administrative assistance. These studies
   were supported by NIH grants DK107220 and DK112698 (to R.J.D.) and
   American Heart Association grant 16SDG29660007 (to S.K.). The UMASS
   Mouse Metabolic Phenotyping Center is supported by NIH grant DK093000
   (to J.K.K.). R.A.F. and R.J.D. are investigators of the Howard Hughes
   Medical Institute.
CR Alvarez-Curto E, 2016, BIOCHEM PHARMACOL, V114, P3, DOI 10.1016/j.bcp.2016.03.017
   Badea TC, 2003, J NEUROSCI, V23, P2314
   Brancho D, 2005, MOL CELL BIOL, V25, P3670, DOI 10.1128/MCB.25.9.3670-3681.2005
   Chen T, 2009, BIOCHEM J, V420, P283, DOI 10.1042/BJ20081899
   Craige SM, 2016, BBA-MOL BASIS DIS, V1862, P1581, DOI 10.1016/j.bbadis.2016.05.022
   Crespo P, 1996, ONCOGENE, V13, P455
   Crespo P, 1997, NATURE, V385, P169, DOI 10.1038/385169a0
   D'Ambrosio C, 2006, MOL CELL PROTEOMICS, V5, P97, DOI 10.1074/mcp.M500226-MCP200
   Dajas-Ballador F, 2008, CURR BIOL, V18, P221, DOI 10.1016/j.cub.2008.01.025
   DAVIS RJ, 1994, TRENDS BIOCHEM SCI, V19, P470, DOI 10.1016/0968-0004(94)90132-5
   Davis RJ, 2000, CELL, V103, P239, DOI 10.1016/S0092-8674(00)00116-1
   Flegal KM, 2013, JAMA-J AM MED ASSOC, V309, P71, DOI 10.1001/jama.2012.113905
   Fu SN, 2012, CELL METAB, V15, P623, DOI 10.1016/j.cmet.2012.03.007
   Fujikawa K, 2003, J EXP MED, V198, P1595, DOI 10.1084/jem.20030874
   Heo JS, 2004, EMBO J, V23, P2185, DOI 10.1038/sj.emboj.7600212
   Hernandez ED, 2014, CELL METAB, V20, P499, DOI 10.1016/j.cmet.2014.06.008
   Holzer RG, 2011, CELL, V147, P173, DOI 10.1016/j.cell.2011.08.034
   Hu W, 2009, J LIPID RES, V50, P1852, DOI 10.1194/jlr.M800635-JLR200
   Hübner A, 2012, P NATL ACAD SCI USA, V109, P12046, DOI 10.1073/pnas.1209660109
   Jaeschke A, 2004, GENE DEV, V18, P1976, DOI 10.1101/gad.1216504
   Jaeschke A, 2007, MOL CELL, V27, P498, DOI 10.1016/j.molcel.2007.07.008
   Kahn SE, 2006, NATURE, V444, P840, DOI 10.1038/nature05482
   Kaneto H, 2004, NAT MED, V10, P1128, DOI 10.1038/nm1111
   Kant S, 2013, CELL REP, V4, P681, DOI 10.1016/j.celrep.2013.07.019
   Kant S, 2011, GENE DEV, V25, P2069, DOI 10.1101/gad.17224711
   Kennedy NJ, 2007, GENE DEV, V21, P2336, DOI 10.1101/gad.1563107
   Klinghoffer RA, 1999, EMBO J, V18, P2459, DOI 10.1093/emboj/18.9.2459
   Lamb JA, 2003, MOL CELL, V11, P1479, DOI 10.1016/S1097-2765(03)00203-X
   Lingwood D, 2007, NAT PROTOC, V2, P2159, DOI 10.1038/nprot.2007.294
   Montell E, 2001, AM J PHYSIOL-ENDOC M, V280, pE229, DOI 10.1152/ajpendo.2001.280.2.E229
   Moran BM, 2016, ACTA DIABETOL, V53, P177, DOI 10.1007/s00592-015-0826-9
   Morel C, 2010, MOL CELL BIOL, V30, P4616, DOI 10.1128/MCB.00585-10
   MORGENSTERN JP, 1990, NUCLEIC ACIDS RES, V18, P3587, DOI 10.1093/nar/18.12.3587
   Neuschwander-Tetri BA, 2010, HEPATOLOGY, V52, P774, DOI 10.1002/hep.23719
   Nihalani D, 2007, MOL CELL BIOL, V27, P2431, DOI 10.1128/MCB.01479-06
   Sabio G, 2010, TRENDS BIOCHEM SCI, V35, P490, DOI 10.1016/j.tibs.2010.04.004
   Sharma M, 2012, J HEPATOL, V56, P192, DOI 10.1016/j.jhep.2011.03.019
   SONGYANG Z, 1994, MOL CELL BIOL, V14, P2777, DOI 10.1128/MCB.14.4.2777
   Standen CL, 2009, MOL CELL BIOL, V29, P4831, DOI 10.1128/MCB.00155-09
   Stebbins JL, 2008, P NATL ACAD SCI USA, V105, P16809, DOI 10.1073/pnas.0805677105
   Teramoto H, 1996, J BIOL CHEM, V271, P27225, DOI 10.1074/jbc.271.44.27225
   Whitmarsh AJ, 1998, SCIENCE, V281, P1671, DOI 10.1126/science.281.5383.1671
   Whitmarsh AJ, 2001, GENE DEV, V15, P2421, DOI 10.1101/gad.922801
   Yasuda J, 1999, MOL CELL BIOL, V19, P7245
   ZHOU SY, 1993, CELL, V72, P767, DOI 10.1016/0092-8674(93)90404-E
NR 45
TC 31
Z9 33
U1 0
U2 6
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 2211-1247
J9 CELL REP
JI Cell Reports
PD SEP 19
PY 2017
VL 20
IS 12
BP 2775
EP 2783
DI 10.1016/j.celrep.2017.08.025
PG 9
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA FH4LZ
UT WOS:000411127400004
PM 28930674
OA Green Published, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Meadows, JL
   Vaughan, DE
AF Meadows, Judith L.
   Vaughan, Douglas E.
TI Endothelial biology in the post-menopausal obese woman
SO MATURITAS
LA English
DT Review
DE Endothelial function; Nitric oxide; Vasodilation; Menopause; Gender;
   Vascular function; Cardiovascular disease; Obesity; Aging; Metabolic
   syndrome
ID PLASMINOGEN ACTIVATOR RELEASE; OBSTRUCTIVE SLEEP-APNEA; ESTROGEN PLUS
   PROGESTIN; METABOLIC SYNDROME; INSULIN-RESISTANCE; DEPENDENT
   VASODILATION; OXIDATIVE STRESS; HORMONE-THERAPY; CARDIOVASCULAR-DISEASE;
   VASCULAR-DISEASE
AB Women generally have a reduced risk of cardiovascular disease (CVD). However, this protection of gender diminishes rapidly after menopause and with advancing age, particularly in obese women. Alterations in vascular function are thought to a key early step in the development of atherosclerosis. In this review, we will describe the features of endothelial dysfunction in the post-menopausal obese female and discuss the interplay of aging, estrogen withdrawal, and obesity. The objectives include (1) a review of endothelial biology and endothelial dysfunction, and (2) a discussion how the endothelial function is altered in the context of aging, hormonal changes and insulin resistance. The clinical consequences of endothelial dysfunction and CVD will also be reviewed. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
C1 [Meadows, Judith L.; Vaughan, Douglas E.] NW Univ Feinberg, Sch Med, Dept Med, Div Cardiol, Chicago, IL 60611 USA.
C3 Northwestern University; Feinberg School of Medicine
RP Vaughan, DE (corresponding author), NW Univ Feinberg, Sch Med, Dept Med, Div Cardiol, Chicago, IL 60611 USA.
EM d-vaughan@northwestern.edu
FU National Institutes of Health, Bethesda, MD [HL51387, P50 HL 081009]
FX This work was supported in part by grants HL51387 and P50 HL 081009 from
   the National Institutes of Health, Bethesda, MD.
CR Alexandersen P, 2006, CLIMACTERIC, V9, P108, DOI 10.1080/13697130600647743
   Anand SS, 2008, EUR HEART J, V29, P932, DOI 10.1093/eurheartj/ehn018
   Anand SS, 2003, CIRCULATION, V108, P420, DOI 10.1161/01.CIR.0000080884.27358.49
   Anderson B, 2008, AM J EMERG MED, V26, P62, DOI 10.1016/j.ajem.2007.06.026
   [Anonymous], 2000, WHO TECH REP SER, V894, pi
   Arcaro G, 1999, INT J OBESITY, V23, P936, DOI 10.1038/sj.ijo.0801022
   Arora S, 1998, J VASC SURG, V27, P1141, DOI 10.1016/S0741-5214(98)70016-3
   Athyros VG, 2004, CURR MED RES OPIN, V20, P1691, DOI 10.1185/030079904X5599
   Bahia Luciana, 2006, Clinics, V61, P433, DOI 10.1590/S1807-59322006000500010
   Benjamin EJ, 2004, CIRCULATION, V109, P613, DOI 10.1161/01.CIR.0000112565.60887.1E
   Berg AH, 2005, CIRC RES, V96, P939, DOI 10.1161/01.RES.0000163635.62927.34
   Blanco-Colio LM, 2007, AM HEART J, V153, P881, DOI 10.1016/j.ahj.2007.02.029
   Brook RD, 2001, AM J CARDIOL, V88, P1264, DOI 10.1016/S0002-9149(01)02088-4
   Brown NJ, 2000, CIRCULATION, V102, P2190
   Carroll S, 2007, APPL PHYSIOL NUTR ME, V32, P125, DOI 10.1139/h06-093
   CELERMAJER DS, 1994, J AM COLL CARDIOL, V24, P471, DOI 10.1016/0735-1097(94)90305-0
   Czernichow S, 2010, J HYPERTENS, V28, P325, DOI 10.1097/HJH.0b013e328333d1fc
   Deanfield JE, 2007, CIRCULATION, V115, P1285, DOI 10.1161/CIRCULATIONAHA.106.652859
   Dubey RK, 2005, CARDIOVASC RES, V66, P295, DOI 10.1016/j.cardiores.2004.12.012
   Duckles SP, 2006, MOL INTERV, V6, P26, DOI 10.1124/mi.6.1.6
   Dyugovskaya L, 2002, AM J RESP CRIT CARE, V165, P934, DOI 10.1164/ajrccm.165.7.2104126
   Félétou M, 2006, AM J PHYSIOL-HEART C, V291, pH985, DOI 10.1152/ajpheart.00292.2006
   Ford ES, 2005, DIABETES CARE, V28, P2745, DOI 10.2337/diacare.28.11.2745
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Gerhard M, 1996, HYPERTENSION, V27, P849, DOI 10.1161/01.HYP.27.4.849
   Ghiadoni L, 2008, HYPERTENSION, V51, P440, DOI 10.1161/HYPERTENSIONAHA.107.103093
   Goldstein BJ, 2004, J CLIN ENDOCR METAB, V89, P2563, DOI 10.1210/jc.2004-0518
   Grodstein F, 1997, NEW ENGL J MED, V336, P1769, DOI 10.1056/NEJM199706193362501
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hamburg NM, 2008, AM J CARDIOL, V101, P82, DOI 10.1016/j.amjcard.2007.07.053
   Jelic S, 2008, CIRCULATION, V117, P2270, DOI 10.1161/CIRCULATIONAHA.107.741512
   Jelic S, 2010, CIRCULATION, V121, P1014, DOI 10.1161/CIRCULATIONAHA.109.900357
   Jensen-Urstad K, 2001, J INTERN MED, V250, P29, DOI 10.1046/j.1365-2796.2001.00843.x
   KANNEL WB, 1976, ANN INTERN MED, V85, P447, DOI 10.7326/0003-4819-85-4-447
   Kato M, 2000, CIRCULATION, V102, P2607
   Kuvin JT, 2003, AM HEART J, V146, P168, DOI 10.1016/S0002-8703(03)00094-2
   Lee SJ, 2001, DIABETES RES CLIN PR, V54, pS81, DOI 10.1016/S0168-8227(01)00339-4
   Lew R, 2003, CIRC RES, V93, P1127, DOI 10.1161/01.RES.0000103633.57225.BC
   LIEBERMAN EH, 1994, ANN INTERN MED, V121, P936, DOI 10.7326/0003-4819-121-12-199412150-00005
   Lind L, 2008, ATHEROSCLEROSIS, V196, P795, DOI 10.1016/j.atherosclerosis.2007.01.014
   Lteif AA, 2005, CIRCULATION, V112, P32, DOI 10.1161/CIRCULATIONAHA.104.520130
   Manson JE, 2003, NEW ENGL J MED, V349, P523, DOI 10.1056/NEJMoa030808
   MCQUILLAN LP, 1994, AM J PHYSIOL-HEART C, V267, pH1921
   Mendelsohn ME, 1999, NEW ENGL J MED, V340, P1801, DOI 10.1056/NEJM199906103402306
   Miller VM, 2008, PHARMACOL REV, V60, P210, DOI 10.1124/pr.107.08002
   Ogden CL, 2006, JAMA-J AM MED ASSOC, V295, P1549, DOI 10.1001/jama.295.13.1549
   Oliver JJ, 2005, ARTERIOSCL THROM VAS, V25, P2470, DOI 10.1161/01.ATV.0000189309.05924.88
   Ouchi N, 2003, HYPERTENSION, V42, P231, DOI 10.1161/01.HYP.0000083488.67550.B8
   Peker Y, 1999, EUR RESPIR J, V14, P179, DOI 10.1034/j.1399-3003.1999.14a30.x
   Peppard PE, 2000, NEW ENGL J MED, V342, P1378, DOI 10.1056/NEJM200005113421901
   Post WS, 1999, CARDIOVASC RES, V43, P985, DOI 10.1016/S0008-6363(99)00153-4
   Pou KM, 2007, CIRCULATION, V116, P1234, DOI 10.1161/CIRCULATIONAHA.107.710509
   Pretorius M, 2005, ARTERIOSCL THROM VAS, V25, P2435, DOI 10.1161/01.ATV.0000186185.13977.94
   Pretorius M, 2008, HYPERTENSION, V51, P1190, DOI 10.1161/HYPERTENSIONAHA.107.105627
   Robinson SD, 2007, ARTERIOSCL THROM VAS, V27, P1651, DOI 10.1161/ATVBAHA.107.143248
   Rossouw JE, 2007, JAMA-J AM MED ASSOC, V297, P1465, DOI 10.1001/jama.297.13.1465
   Rossouw JE, 2002, JAMA-J AM MED ASSOC, V288, P321, DOI 10.1001/jama.288.3.321
   Sherwood A, 2007, ARTERIOSCL THROM VAS, V27, P1782, DOI 10.1161/ATVBAHA.107.145383
   Stevenson JC, 2007, MATURITAS, V57, P31, DOI 10.1016/j.maturitas.2007.02.007
   Taddei S, 2001, HYPERTENSION, V38, P274, DOI 10.1161/01.HYP.38.2.274
   Vázquez LA, 2005, J CLIN ENDOCR METAB, V90, P316, DOI 10.1210/jc.2003-032059
   Virdis A, 2010, MATURITAS, V67, P20, DOI 10.1016/j.maturitas.2010.04.006
   Vitale C, 2008, ARTERIOSCL THROM VAS, V28, P348, DOI 10.1161/ATVBAHA.107.158634
   Yaggi HK, 2005, NEW ENGL J MED, V353, P2034, DOI 10.1056/NEJMoa043104
   You TJ, 2008, J GERONTOL A-BIOL, V63, P414, DOI 10.1093/gerona/63.4.414
   Young T, 2002, ARCH INTERN MED, V162, P893, DOI 10.1001/archinte.162.8.893
   Yudkin JS, 2005, LANCET, V365, P1817, DOI 10.1016/S0140-6736(05)66585-3
   Zhang C, 2008, CIRCULATION, V117, P1658, DOI 10.1161/CIRCULATIONAHA.107.739714
   Ziccardi P, 2002, CIRCULATION, V105, P804, DOI 10.1161/hc0702.104279
NR 69
TC 17
Z9 20
U1 0
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD JUN
PY 2011
VL 69
IS 2
BP 120
EP 125
DI 10.1016/j.maturitas.2011.03.012
PG 6
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA 780EP
UT WOS:000291837600006
PM 21530115
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Rodríguez-Vera, D
   Vergara-Castañeda, A
   Lazcano-Orozco, DK
   Ramírez-Vélez, G
   Vivar-Sierra, A
   Araiza-Macías, MJ
   Hernández-Contreras, JP
   Naranjo-Navarro, CR
   Salazar, JR
   Loza-Mejía, MA
   Pinto-Almazán, R
AF Rodriguez-Vera, Diana
   Vergara-Castaneda, Arely
   Lazcano-Orozco, Diana K.
   Ramirez-Velez, Gabriela
   Vivar-Sierra, Alonso
   Jose Araiza-Macias, Maria
   Patricio Hernandez-Contreras, Jose
   Rogelio Naranjo-Navarro, Carlos
   Rodrigo Salazar, Juan
   Loza-Mejia, Marco A.
   Pinto-Almazan, Rodolfo
TI Inflammation Parameters Associated with Metabolic Disorders:
   Relationship Between Diet and Microbiota
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE metabolic syndrome; obesity; hypertension; insulin resistance;
   microbiota; diet
ID C-REACTIVE PROTEIN; HYPERTENSION DASH DIET; NECROSIS-FACTOR-ALPHA;
   ADIPOSE-TISSUE; INSULIN-RESISTANCE; GUT MICROBIOTA; ENDOTHELIAL
   FUNCTION; MEDITERRANEAN DIET; OXIDATIVE STRESS; CARDIOVASCULAR RISK
AB The metabolic syndrome (MetS) includes numerous interrelated clinical, anthropometric, biochemical, and metabolic components and has become a public health problem due to its impact on morbimortality. Inflammation is a central mechanism underlying the etiology and clinical manifestations of MetS, contributing to its related pathological outcomes. Dietary patterns have been associated with the promotion of the diversity of microbiota in the digestive tract. Recently, research has focused on the importance of microbiota changes associated with MetS and inflammation. Other studies have been performed to understand the impact of prebiotics, probiotics, and synbiotics as allies on diet, inflammation, and MetS parameters. This review analyses the correlation between metabolic disorders, inflammation parameters, gut microbiota, and how diet has been involved as treatment of MetS and the modulation of inflammation and microbiota.
C1 [Rodriguez-Vera, Diana; Lazcano-Orozco, Diana K.; Pinto-Almazan, Rodolfo] High Specialty Reg Hosp Ixtapaluca HRAEI, Res Unit, Mol Biol Metab & Neurodegenerat Dis Lab, Carretera Fed Mexico Puebla Km 34-5, Ixtapaluca 56530, Mexico.
   [Rodriguez-Vera, Diana; Pinto-Almazan, Rodolfo] Inst Politecn Nacl, Escuela Super Med, Secc Estudios Posgrad & Invest, Mexico City, DF, Mexico.
   [Vergara-Castaneda, Arely] Univ La Salle Mexico, Chem Sci Sch, Basic & Clin Hlth Sci Res Grp, Mexico City, DF, Mexico.
   [Ramirez-Velez, Gabriela; Vivar-Sierra, Alonso; Jose Araiza-Macias, Maria; Patricio Hernandez-Contreras, Jose; Rogelio Naranjo-Navarro, Carlos; Rodrigo Salazar, Juan; Loza-Mejia, Marco A.] Univ La Salle Mexico, Chem Sci Sch, Design Isolat & Synth Bioact Mol Res Grp, Benjamin Franklin 45, Mexico City 06140, DF, Mexico.
C3 Instituto Politecnico Nacional - Mexico
RP Pinto-Almazán, R (corresponding author), High Specialty Reg Hosp Ixtapaluca HRAEI, Res Unit, Mol Biol Metab & Neurodegenerat Dis Lab, Carretera Fed Mexico Puebla Km 34-5, Ixtapaluca 56530, Mexico.; Loza-Mejía, MA (corresponding author), Univ La Salle Mexico, Chem Sci Sch, Design Isolat & Synth Bioact Mol Res Grp, Benjamin Franklin 45, Mexico City 06140, DF, Mexico.
RI Vergara-Castañeda, Arely/IUN-2401-2023; Ramírez-Vélez,
   Robinson/D-5311-2016; Loza-Mejia, Marco A./F-3557-2019; Pinto-Almazan,
   Rodolfo/F-3483-2013
OI Vivar-Sierra, Alonso/0000-0002-9267-2669; VERGARA-CASTANEDA,
   ARELY/0000-0002-9366-3211; Loza-Mejia, Marco A./0000-0002-8449-0806;
   Pinto-Almazan, Rodolfo/0000-0002-5210-5395
FU Doctorate Degree in Medicine Research Program
FX This work was submitted in partial fulfillment of the requirements for
   the PhD degree of D.R.-V. at the Doctorate Degree in Medicine Research
   Program.
CR Agita A, 2017, ACTA MED INDONES, V49, P158
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   [Anonymous], 2006, YOUR GUID LOW YOUR B
   Arkan MC, 2005, NAT MED, V11, P191, DOI 10.1038/nm1185
   Armougom F, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007125
   Asemi Z, 2013, ANN NUTR METAB, V63, P1, DOI 10.1159/000349922
   Asztalos BF, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0109238
   Azadbakht L, 2005, DIABETES CARE, V28, P2823, DOI 10.2337/diacare.28.12.2823
   Babio N, 2009, NUTR METAB CARDIOVAS, V19, P563, DOI 10.1016/j.numecd.2008.10.007
   Bautista LE, 2005, J HUM HYPERTENS, V19, P149, DOI 10.1038/sj.jhh.1001785
   Bochud M, 2009, J CLIN ENDOCR METAB, V94, P3969, DOI 10.1210/jc.2008-2428
   Braune J, 2017, J IMMUNOL, V198, P2927, DOI 10.4049/jimmunol.1600476
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Cao SS, 2012, CURR BIOL, V22, pR622, DOI 10.1016/j.cub.2012.07.004
   Castro-Barquero S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12102983
   Chen JY, 2020, J TRANSL MED, V18, DOI 10.1186/s12967-020-02226-x
   Chiavaroli L, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020338
   Chrysohoou C, 2004, AM J HYPERTENS, V17, P568, DOI 10.1016/j.amjhyper.2004.03.675
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Clemente JC, 2012, CELL, V148, P1258, DOI 10.1016/j.cell.2012.01.035
   Coletta DK, 2011, AM J PHYSIOL-ENDOC M, V301, pE749, DOI 10.1152/ajpendo.00363.2011
   Cryan JF, 2019, PHYSIOL REV, V99, P1877, DOI 10.1152/physrev.00018.2018
   Dalekos GN, 1997, J LAB CLIN MED, V129, P300, DOI 10.1016/S0022-2143(97)90178-5
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   David LA, 2014, GENOME BIOL, V15, DOI 10.1186/gb-2014-15-7-r89
   De Filippis Francesca, 2016, Gut, V65, P1812, DOI 10.1136/gutjnl-2015-309957
   Diedisheim M, 2020, MOL METAB, V41, DOI 10.1016/j.molmet.2020.101041
   Dimas AS, 2014, DIABETES, V63, P2158, DOI 10.2337/db13-0949
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   Esteve E, 2005, CLIN NUTR, V24, P16, DOI 10.1016/j.clnu.2004.08.004
   Fernandez-Real JM, 2001, J CLIN ENDOCR METAB, V86, P1154, DOI 10.1210/jc.86.3.1154
   Flint HJ, 2012, NAT REV GASTRO HEPAT, V9, P577, DOI 10.1038/nrgastro.2012.156
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Furumoto T, 2002, HYPERTENS RES, V25, P475, DOI 10.1291/hypres.25.475
   Gallus S, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-29867-9
   Ghanim H, 2009, DIABETES CARE, V32, P2281, DOI 10.2337/dc09-0979
   Gibiino G, 2018, DIGEST LIVER DIS, V50, P635, DOI 10.1016/j.dld.2018.03.016
   Gordon S, 2003, NAT REV IMMUNOL, V3, P23, DOI 10.1038/nri978
   GOUNI I, 1993, J LIPID RES, V34, P139
   Grandl G, 2018, SEMIN IMMUNOPATHOL, V40, P215, DOI 10.1007/s00281-017-0666-5
   Guevara-Cruz M, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.119.012401
   Hajer GR, 2008, EUR HEART J, V29, P2959, DOI 10.1093/eurheartj/ehn387
   Hardardottir Ingibjorg, 1994, Current Opinion in Lipidology, V5, P207, DOI 10.1097/00041433-199405030-00008
   Haro C, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201700300
   HAVEL RJ, 1987, AM J PHYSIOL, V253, pE1, DOI 10.1152/ajpendo.1987.253.1.E1
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   HOTAMISLIGIL GS, 1995, J CLIN INVEST, V95, P2409, DOI 10.1172/JCI117936
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Huynh MLN, 2002, J CLIN INVEST, V109, P41, DOI 10.1172/JCI11638
   Idris-Khodja N, 2014, EUR HEART J, V35, P1238, DOI 10.1093/eurheartj/ehu119
   Jandhyala SM, 2015, WORLD J GASTROENTERO, V21, P8787, DOI 10.3748/wjg.v21.i29.8787
   Jiang CY, 1998, NATURE, V391, P82, DOI 10.1038/34184
   Kahleova H, 2020, NUTRIENTS, V12, DOI 10.3390/nu12102917
   Kallio KAE, 2015, ACTA DIABETOL, V52, P395, DOI 10.1007/s00592-014-0662-3
   Kellow NJ, 2014, BMC ENDOCR DISORD, V14, DOI 10.1186/1472-6823-14-55
   Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2548, DOI 10.1210/jc.2004-0395
   Key TJ, 1999, AM J CLIN NUTR, V70, p516S, DOI 10.1093/ajcn/70.3.516s
   Khovidhunkit W, 2000, J INFECT DIS, V181, pS462, DOI 10.1086/315611
   Koupenova M, 2018, CIRC RES, V122, P337, DOI 10.1161/CIRCRESAHA.117.310795
   Kulkarni P, 2021, BMC RES NOTES, V14, DOI 10.1186/s13104-021-05466-2
   Lankinen M, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061369
   LAW MR, 1994, BMJ-BRIT MED J, V308, P363, DOI 10.1136/bmj.308.6925.363
   Lazar V, 2019, FRONT NUTR, V6, DOI 10.3389/fnut.2019.00021
   Lin Y, 2000, J BIOL CHEM, V275, P24255, DOI 10.1074/jbc.M002137200
   Lopes HF, 2003, HYPERTENSION, V41, P422, DOI 10.1161/01.HYP.0000053450.19998.11
   Luisi MLE, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.01366
   Lumeng CN, 2007, J CLIN INVEST, V117, P175, DOI 10.1172/JCI29881
   Matijasic BB, 2014, EUR J NUTR, V53, P1051, DOI 10.1007/s00394-013-0607-6
   McLoughlin RF, 2017, AM J CLIN NUTR, V106, P930, DOI 10.3945/ajcn.117.156265
   Meslier V, 2020, GUT, V69, P1258, DOI 10.1136/gutjnl-2019-320438
   Misra A, 2009, METAB SYNDR RELAT D, V7, P497, DOI 10.1089/met.2009.0024
   Mithril C, 2013, PUBLIC HEALTH NUTR, V16, P777, DOI 10.1017/S1368980012004521
   Mithril C, 2012, PUBLIC HEALTH NUTR, V15, P1941, DOI 10.1017/S136898001100351X
   Monteiro R, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/289645
   Monteiro Rosario, 2009, P65, DOI 10.1007/978-1-4020-9701-0_4
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   NAVAB M, 1988, J CLIN INVEST, V81, P601, DOI 10.1172/JCI113359
   Cândido TLN, 2018, NUTR HOSP, V35, P1432, DOI 10.20960/nh.1792
   Ogurtsova K, 2017, DIABETES RES CLIN PR, V128, P40, DOI 10.1016/j.diabres.2017.03.024
   Oram JF, 2002, CURR OPIN LIPIDOL, V13, P373, DOI 10.1097/00041433-200208000-00004
   Palta S, 2014, INDIAN J ANAESTH, V58, P515, DOI 10.4103/0019-5049.144643
   Pérez-Martínez P, 2017, NUTR REV, V75, P307, DOI 10.1093/nutrit/nux014
   Phillips C, 2006, CURR OPIN CARDIOL, V21, P185, DOI 10.1097/01.hco.0000221579.25878.11
   Phillips CM, 2019, CLIN NUTR, V38, P1620, DOI 10.1016/j.clnu.2018.08.028
   Qatanani M, 2007, GENE DEV, V21, P1443, DOI 10.1101/gad.1550907
   Rabiei S, 2019, J DIET SUPPL, V16, P294, DOI 10.1080/19390211.2018.1455788
   Rallidis LS, 2009, AM J CLIN NUTR, V90, P263, DOI 10.3945/ajcn.2008.27290
   Ranasinghe P, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4041-1
   Riviere A, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.00979
   Roche HM, 2005, P NUTR SOC, V64, P371, DOI 10.1079/PNS2005445
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Sabaté JM, 2008, OBES SURG, V18, P371, DOI 10.1007/s11695-007-9398-2
   Sabaté J, 2015, BRIT J NUTR, V113, pS136, DOI 10.1017/S0007114514004139
   Sabico S, 2019, CLIN NUTR, V38, P1561, DOI 10.1016/j.clnu.2018.08.009
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Saltiel AR, 2000, J CLIN INVEST, V106, P163, DOI 10.1172/JCI10533
   Savini I, 2013, INT J MOL SCI, V14, P10497, DOI 10.3390/ijms140510497
   Schwingshackl L, 2014, NUTR METAB CARDIOVAS, V24, P929, DOI 10.1016/j.numecd.2014.03.003
   SERNATINGER J, 1988, J GEN VIROL, V69, P2657, DOI 10.1099/0022-1317-69-10-2657
   Serra-Majem L., 2015, Mediterranean food consumption patterns Diet, environment, society, economy and health, DOI [10.13140/RG.2.1.3823.2405, DOI 10.13140/RG.2.1.3823.2405]
   Sesso HD, 2003, JAMA-J AM MED ASSOC, V290, P2945, DOI 10.1001/jama.290.22.2945
   Shirani F, 2013, NUTRITION, V29, P939, DOI 10.1016/j.nut.2012.12.021
   Skurk T, 2007, J CLIN ENDOCR METAB, V92, P1023, DOI 10.1210/jc.2006-1055
   Soares Raquel, 2009, P85, DOI 10.1007/978-1-4020-9701-0_5
   Soltani S, 2016, OBES REV, V17, P442, DOI 10.1111/obr.12391
   Sonnenberg L, 2005, OBES RES, V13, P153, DOI 10.1038/oby.2005.20
   Stumpf C, 2009, EUR J CLIN INVEST, V39, P31, DOI 10.1111/j.1365-2362.2008.02056.x
   Surendar J, 2011, DIABETES TECHNOL THE, V13, P477, DOI 10.1089/dia.2010.0178
   Takagi H, 2013, J AM SOC HYPERTENS, V7, P229, DOI 10.1016/j.jash.2013.02.006
   Tenorio-Jiménez C, 2018, BMC COMPLEM ALTERN M, V18, DOI 10.1186/s12906-018-2371-x
   Trayhurn P, 2008, BRIT J NUTR, V100, P227, DOI 10.1017/S0007114508971282
   van Dielen FMH, 2004, J CLIN ENDOCR METAB, V89, P4062, DOI 10.1210/jc.2003-032125
   van Dijk SJ, 2009, AM J CLIN NUTR, V90, P1656, DOI 10.3945/ajcn.2009.27792
   Vanegas SM, 2017, AM J CLIN NUTR, V105, P635, DOI 10.3945/ajcn.116.146928
   Vázquez LA, 2005, J CLIN ENDOCR METAB, V90, P316, DOI 10.1210/jc.2003-032059
   Velloso LA, 1996, P NATL ACAD SCI USA, V93, P12490, DOI 10.1073/pnas.93.22.12490
   Versteeg HH, 2013, PHYSIOL REV, V93, P327, DOI 10.1152/physrev.00016.2011
   Voight BF, 2010, NAT GENET, V42, P579, DOI 10.1038/ng.609
   Wan Y, 2019, GUT, V68, P1417, DOI 10.1136/gutjnl-2018-317609
   Welsh P, 2010, J CLIN ENDOCR METAB, V95, P93, DOI 10.1210/jc.2009-1064
   Welty FK, 2016, TRANSL RES, V167, P257, DOI 10.1016/j.trsl.2015.06.017
   Wolowczuk I, 2008, CLIN DEV IMMUNOL, P1, DOI 10.1155/2008/639803
   Wu Y, 2018, CURR OPIN HEMATOL, V25, P389, DOI 10.1097/MOH.0000000000000448
   Wu Y, 2015, THROMB J, V13, DOI 10.1186/s12959-015-0048-y
   XIE QW, 1994, J BIOL CHEM, V269, P4705
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Xu T, 2008, CIRC J, V72, P1324, DOI 10.1253/circj.72.1324
   Yu X, 2010, RENAL FAILURE, V32, P475, DOI 10.3109/08860221003664280
   Zhao SP, 2004, CLIN CHIM ACTA, V344, P195, DOI 10.1016/j.cccn.2004.03.003
   Zhou MS, 2012, VASC MED, V17, P330, DOI 10.1177/1358863X12450094
   Zhu CH, 2020, NUTR RES, V77, P62, DOI 10.1016/j.nutres.2020.03.005
NR 135
TC 6
Z9 6
U1 0
U2 7
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD NOV 1
PY 2021
VL 19
IS 9
BP 469
EP 482
DI 10.1089/met.2021.0022
EA AUG 2021
PG 14
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA WV6IJ
UT WOS:000685557400001
PM 34402660
DA 2025-06-11
ER

PT J
AU Minár, M
   Dragasek, J
   Valkovic, P
AF Minar, Michal
   Dragasek, Jozef
   Valkovic, Peter
TI Psychiatric and somatic co-morbidities in patients with Parkinson's
   disease: A STROBE-compliant national multi-center, cross-sectional,
   observational study COSMOS in Slovakia
SO NEUROENDOCRINOLOGY LETTERS
LA English
DT Article
DE Parkinson's disease; prevalence; co-morbidity; psychiatric; somatic
ID QUALITY-OF-LIFE; SLEEP DISORDERS; COMORBIDITIES; POPULATION; PREVALENCE;
   FREQUENCY; IMPACT
AB OBJECTIVE: Co-morbidities in any disorder can complicate its diagnostic process, they require more complex clinical management and lead to worse health outcomes and increased healthcare costs. There are regional differences in the prevalence of specific co-morbidities in Parkinson's disease (PD), and data from middle Europe are lacking. The project COSMOS aimed to disclose the prevalence of co-morbidities among patients with PD in Slovakia.
   METHODS: In a national, multi-center, cross-sectional, observational study, neurologists gathered relevant demographical and clinical data aimed at all psychiatric and somatic co-morbidities.
   RESULTS: From overall 737 patients, 51.00 % had at least one psychiatric co-morbidity, the most prevalent were depressive episode/recurrent depressive disorder (26.05%), sleep disorders (23.20%), dementia (13.16%), and neurotic, stress-related, and somatoform disorders (11.53%). In addition, 92.9 % had at least one somatic co-morbidity, the most prevalent were hypertensive diseases (67.71%), ischemic heart diseases (42.74%), diseases of the musculoskeletal system, and connective tissue (39.21), and disorders of lipoprotein metabolism (33.24%). The number of psychiatric co-morbidities increased with PD progression; the prevalence of somatic comorbidities increased also with the age (p<0.001 in all cases).
   CONCLUSION: This study with a large cohort of PD patients confirmed a high prevalence of depression, dementia, sleep problems, and anxiety disorders, together with cardiovascular disorders, diseases of the musculoskeletal system, and metabolic syndrome. With PD progression, the number of both psychiatric and somatic co-morbidities is on the increase. If not treated properly, they lead to more complicated management. That's why it's essential to search for any co-morbidity to provide patients with early and adequate therapy to avoid further worsening of quality of life.
C1 [Minar, Michal; Valkovic, Peter] Comenius Univ, Univ Hosp Bratislava, Fac Med, Dept Neurol 2, Bratislava, Slovakia.
   [Dragasek, Jozef] Pavol Jozef Safarik Univ, Dept Psychiat 1, Kosice, Slovakia.
   [Valkovic, Peter] Slovak Acad Sci, Ctr Expt Med, Inst Normal & Pathol Physiol, Bratislava, Slovakia.
C3 Slovak Medical University Bratislava; Comenius University Bratislava;
   University of Pavol Jozef Safarik Kosice; Slovak Academy of Sciences;
   Institute of Normal & Pathological Physiology, SAS; Centre of
   Experimental Medicine, SAS
RP Minár, M (corresponding author), Comenius Univ, Univ Hosp Bratislava, Fac Med, Dept Neurol 2, Bratislava, Slovakia.
EM mmminar@gmail.com
RI Minár, Michal/AAE-9061-2022; Dragasek, Jozef/B-5070-2010
OI Dragasek, Jozef/0000-0003-2938-6675
FU Krka Slovakia Grant
FX This project was funded by Krka Slovakia Grant.
CR Bach JP, 2012, J NEUROL SCI, V314, P41, DOI 10.1016/j.jns.2011.11.002
   Barone P, 2009, MOVEMENT DISORD, V24, P1641, DOI 10.1002/mds.22643
   Broen MPG, 2016, MOVEMENT DISORD, V31, P1125, DOI 10.1002/mds.26643
   Doi Y, 2011, J EPIDEMIOL, V21, P211, DOI 10.2188/jea.JE20100149
   Gage H, 2003, J NEUROL NEUROSUR PS, V74, P163, DOI 10.1136/jnnp.74.2.163
   Hobson P, 2010, J NEUROL NEUROSUR PS, V81, P1093, DOI 10.1136/jnnp.2009.198689
   Jones JD, 2012, PARKINSONISM RELAT D, V18, P1073, DOI 10.1016/j.parkreldis.2012.06.004
   McLean G, 2017, BMC NEUROL, V17, DOI 10.1186/s12883-017-0904-4
   Mokán M, 2008, DIABETES RES CLIN PR, V81, P238, DOI 10.1016/j.diabres.2008.04.002
   Nalls MA, 2014, HUM MOL GENET, V23, P831, DOI 10.1093/hmg/ddt465
   Nuti A, 2004, EUR J NEUROL, V11, P315, DOI 10.1111/j.1468-1331.2004.00781.x
   Porter B, 2008, EUR J NEUROL, V15, P46, DOI 10.1111/j.1468-1331.2007.01998.x
   Postuma RB, 2015, MOVEMENT DISORD, V30, P1591, DOI 10.1002/mds.26424
   Riedel O, 2016, INT J GERIATR PSYCH, V31, P938, DOI 10.1002/gps.4414
   Santiago JA, 2017, FRONT AGING NEUROSCI, V9, DOI 10.3389/fnagi.2017.00394
   Sobreira-Neto MA, 2017, EUR NEUROL, V78, P330, DOI 10.1159/000481939
   Valkovic P, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0136541
NR 17
TC 3
Z9 3
U1 0
U2 4
PU MAGHIRA & MAAS PUBLICATIONS
PI MUNSBACH
PA MAGHIRA & MAAS S A R L, 6C, RUE GABRIEL LIPPMANN, L-5365 MUNSBACH,
   LUXEMBOURG
SN 0172-780X
EI 2354-4716
J9 NEUROENDOCRINOL LETT
JI Neuroendocrinol. Lett.
PY 2022
VL 43
IS 1
BP 39
EP 44
PG 6
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 9M6TN
UT WOS:000942359700005
PM 35490424
DA 2025-06-11
ER

PT J
AU Pothinam, S
   Putpim, C
   Siriwoharn, T
   Jirarattanarangsri, W
AF Pothinam, Suwajee
   Putpim, Chaochetdhapada
   Siriwoharn, Thanyaporn
   Jirarattanarangsri, Wachira
TI Effects of Perilla Seed Oil on Blood Lipids, Oxidative Stress, and
   Inflammation in Hyperlipidemic Rats
SO FOODS
LA English
DT Article
DE inflammation; metabolic syndrome; omega-3 fatty acids; perilla seed oil
ID ALPHA-LINOLENIC ACID; CARDIOVASCULAR-DISEASE; OMEGA-3-FATTY-ACIDS;
   CHOLESTEROL; METABOLISM; RISK; MECHANISMS; HEALTH; HDL
AB A high-fat diet is a key factor contributing to hyperlipidemia. Perilla seed oil, a plant-based source of omega-3, has the potential to reduce this risk. However, its effects have not been fully established. This study aimed to evaluate the effects of perilla seed oil on blood lipid levels, oxidative stress, and inflammation in rats induced with hyperlipidemia through a high-fat diet. Male Wistar rats were administered perilla seed oil at a dosage of 0.67 g/kg body weight per day for 8 weeks. The results showed that perilla seed oil significantly reduced triglyceride levels by 38.00% and 41.88% and total cholesterol levels by 17.16% and 15.91% in the high-fat diet and normal diet groups, respectively (p < 0.05). However, perilla seed oil had no significant effect on HDL and LDL levels. Additionally, perilla seed oil supplementation significantly reduced malondialdehyde (MDA) levels, a biomarker of oxidative stress, by 68.18% in the high-fat diet group and 29.72% in the normal diet group. Regarding its anti-inflammatory effects, perilla seed oil reduced interleukin-6 (IL-6) levels by 15.21% and 64.27% in the high-fat diet and normal diet groups, respectively (p < 0.05). These findings suggest that perilla seed oil has the potential to reduce the risk of metabolic syndrome.
C1 [Pothinam, Suwajee; Siriwoharn, Thanyaporn; Jirarattanarangsri, Wachira] Chiang Mai Univ, Fac Agroind, Div Food Sci & Technol, Chiang Mai 50100, Thailand.
   [Putpim, Chaochetdhapada] Chiang Mai Univ, Lab Anim Ctr, Off Res Adm, Chiang Mai 50100, Thailand.
C3 Chiang Mai University; Chiang Mai University
RP Siriwoharn, T; Jirarattanarangsri, W (corresponding author), Chiang Mai Univ, Fac Agroind, Div Food Sci & Technol, Chiang Mai 50100, Thailand.
EM suwajeepo@gmail.com; chaochetdhapada.put@cmu.ac.th;
   thanyaporn.s@cmu.ac.th; wachira.j@cmu.ac.th
CR Al-Madhagy S, 2023, EUR J MED RES, V28, DOI 10.1186/s40001-023-01203-6
   Alam SI, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10092274
   Albracht-Schulte K, 2018, J NUTR BIOCHEM, V58, P1, DOI 10.1016/j.jnutbio.2018.02.012
   Asif M, 2011, ORIENTAL PHARM EXP M, V11, P51, DOI 10.1007/s13596-011-0002-x
   Bae SJ, 2020, MOLECULES, V25, DOI 10.3390/molecules25112662
   Bird JK, 2018, NUTRIENTS, V10, DOI 10.3390/nu10060775
   Bishehkolaei M, 2024, HUM NUTR METAB, V37, DOI 10.1016/j.hnm.2024.200275
   Cha Yeseul, 2016, Lab Anim Res, V32, P171
   Danesh J, 2008, PLOS MED, V5, P600, DOI 10.1371/journal.pmed.0050078
   DiNicolantonio James J, 2021, Mo Med, V118, P453
   Elimam H., 2018, J. Appl. Pharm, V10, P257, DOI [DOI 10.21608/JESR.2017.286981, 10.21608/jesr.2017.286981]
   Farhangi MA, 2017, INFLAMMATION, V40, P1688, DOI 10.1007/s10753-017-0610-9
   Farnier M, 2021, ARCH CARDIOVASC DIS, V114, P132, DOI 10.1016/j.acvd.2020.11.006
   Fleming JA, 2014, ADV NUTR, V5, p863S, DOI 10.3945/an.114.005850
   Han H, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/3256241
   Han K, 2020, EUR J LIPID SCI TECH, V122, DOI 10.1002/ejlt.201900443
   Harris WS, 2006, CURR OPIN LIPIDOL, V17, P387, DOI 10.1097/01.mol.0000236363.63840.16
   Hirano T, 2021, INT IMMUNOL, V33, P127, DOI 10.1093/intimm/dxaa078
   Huff T., 2024, StatPearls Internet
   Jain AP, 2015, EUR REV MED PHARMACO, V19, P441
   Kasote D. M., 2013, International Food Research Journal, V20, P27
   Khan SU, 2021, ECLINICALMEDICINE, V38, DOI 10.1016/j.eclinm.2021.100997
   Kim SR, 2019, J MED FOOD, V22, P14, DOI 10.1089/jmf.2018.4226
   Lee JH, 2013, FOOD CHEM, V136, P843, DOI 10.1016/j.foodchem.2012.08.057
   Lewis GF, 2005, CIRC RES, V96, P1221, DOI 10.1161/01.RES.0000170946.56981.5c
   Rocha JÉL, 2022, NUTRIENTS, V14, DOI 10.3390/nu14030426
   Masenga SK, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24097898
   Monserrat-Mesquida M, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9030236
   Morise A, 2005, REPROD NUTR DEV, V45, P405, DOI 10.1051/rnd:2005037
   MORRISON WR, 1964, J LIPID RES, V5, P600
   Mozaffarian D, 2011, J AM COLL CARDIOL, V58, P2047, DOI 10.1016/j.jacc.2011.06.063
   Noeman SA, 2011, DIABETOL METAB SYNDR, V3, DOI 10.1186/1758-5996-3-17
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   Ouimet M, 2019, CIRC RES, V124, P1505, DOI 10.1161/CIRCRESAHA.119.312617
   Packard C, 2000, INT J CARDIOL, V74, pS17, DOI 10.1016/S0167-5273(99)00107-2
   Phillips CM, 2012, J NUTR, V142, P824, DOI 10.3945/jn.111.153460
   Pothinam S, 2025, QUAL ASSUR SAF CROP, V17, P14, DOI 10.15586/qas.v17i1.1509
   Poudyal H, 2011, PROG LIPID RES, V50, P372, DOI 10.1016/j.plipres.2011.06.003
   Pratchayasakul W, 2011, LIFE SCI, V88, P619, DOI 10.1016/j.lfs.2011.02.003
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Shahidi S, 2022, HELIYON, V8, DOI 10.1016/j.heliyon.2022.e09662
   Simopoulos AP, 2002, BIOMED PHARMACOTHER, V56, P365, DOI 10.1016/S0753-3322(02)00253-6
   Singh Z, 2014, IRAN J PUBLIC HEALTH, V43, P7
   Thomas SS, 2020, J MED FOOD, V23, P818, DOI 10.1089/jmf.2019.4675
   Tousoulis D, 2014, ATHEROSCLEROSIS, V232, P10, DOI 10.1016/j.atherosclerosis.2013.10.014
   Viecili PRN, 2017, ADV CLIN CHEM, V80, P1, DOI 10.1016/bs.acc.2016.11.001
   Wali JA, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051505
   Wang HH, 2017, ANN HEPATOL, V16, pS27, DOI 10.5604/01.3001.0010.5495
   Yashodhara BM, 2009, POSTGRAD MED J, V85, P84, DOI 10.1136/pgmj.2008.073338
   Zhang HX, 2021, J SCI FOOD AGR, V101, P1419, DOI 10.1002/jsfa.10755
   Zhang T, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-15
   Zhou XH, 2015, NUTR METAB, V12, DOI 10.1186/s12986-015-0006-5
NR 53
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD APR 17
PY 2025
VL 14
IS 8
AR 1380
DI 10.3390/foods14081380
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 1YD0D
UT WOS:001476413700001
PM 40282780
DA 2025-06-11
ER

PT J
AU Chan, SW
   Tomlinson, B
AF Chan, Sze Wa
   Tomlinson, Brian
TI Effects of Bilberry Supplementation on Metabolic and Cardiovascular
   Disease Risk
SO MOLECULES
LA English
DT Review
DE bilberry; antioxidant; anti-inflammatory; cardiovascular disease;
   hypoglycemic effect; type 2 diabetes
ID VACCINIUM-MYRTILLUS EXTRACT; OXIDATIVE STRESS; WEIGHT-LOSS; ANTIOXIDANT
   CAPACITY; HUMAN HEALTH; INFLAMMATORY CYTOKINES; DIABETES-MELLITUS;
   BLOOD-PRESSURE; SERUM GLUCOSE; VITAMIN-C
AB Metabolic syndrome is a cluster of interrelated conditions that is associated with an increased risk of cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). Oxidative stress may impair normal physiological functions, leading to various illnesses. T2DM is considered to be associated with increased oxidative stress, inflammation, and dyslipidemia, which may play a significant role in the development of cardiovascular complications, cancer and vision loss through cataracts and retinopathy. While conventional therapies are a cornerstone for the management of the major risk factors of metabolic syndrome, increasing antioxidant defense by increasing intake of antioxidant-rich foods may improve long term prospects in CVD, obesity and T2DM. Bilberry (Vaccinium myrtillus L.) is one of the richest natural sources of anthocyanins which give berries their red/purple/blue coloration. Anthocyanins are powerful antioxidants and are reported to play an important role in the prevention of metabolic disease and CVD as well as cancer and other conditions. This review focuses on the potential effects of bilberry supplementation on metabolic and cardiovascular risk factors. Although there is evidence to support the use of bilberry supplementation as part of a healthy diet, the potential benefits from the use of bilberry supplementation in patients with T2DM or CVD needs to be clarified in large clinical trials.
C1 [Chan, Sze Wa] Caritas Inst Higher Educ, Sch Hlth Sci, Hong Kong 999077, Peoples R China.
   [Tomlinson, Brian] Macau Univ Sci & Technol, Fac Med, Macau 853, Peoples R China.
C3 Saint Francis University Hong Kong; Macau University of Science &
   Technology
RP Chan, SW (corresponding author), Caritas Inst Higher Educ, Sch Hlth Sci, Hong Kong 999077, Peoples R China.; Tomlinson, B (corresponding author), Macau Univ Sci & Technol, Fac Med, Macau 853, Peoples R China.
EM swchan@cihe.edu.hk; btomlinson@must.edu.mo
RI Tomlinson, Brian/AAD-9404-2019
OI Chan, Sze Wa/0000-0002-2979-3855; Tomlinson, Brian/0000-0001-6717-5444
FU Caritas Institute of Higher Education [IRG200101]
FX This work is funded by an Internal Research Grant from the Caritas
   Institute of Higher Education, grant number IRG200101.
CR Abd El-Kader SM, 2016, AFR HEALTH SCI, V16, P725, DOI 10.4314/ahs.v16i3.12
   Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
   Andres-Lacueva C, 2005, NUTR NEUROSCI, V8, P111, DOI 10.1080/10284150500078117
   Arevström L, 2019, NUTR RES, V62, P13, DOI 10.1016/j.nutres.2018.11.008
   Arnett DK, 2019, CIRCULATION, V140, pE563, DOI [10.1016/j.jacc.2019.03.009, 10.1016/j.jacc.2019.03.010, 10.1161/CIR.0000000000000678, 10.1161/CIR.0000000000000677]
   Asgary S, 2016, J SCI FOOD AGR, V96, P764, DOI 10.1002/jsfa.7144
   Bagchi D, 2006, MOL CELL BIOCHEM, V281, P197, DOI 10.1007/s11010-006-1030-6
   BAYNES JW, 1991, DIABETES, V40, P405, DOI 10.2337/diabetes.40.4.405
   Biedermann L, 2013, J CROHNS COLITIS, V7, P271, DOI 10.1016/j.crohns.2012.07.010
   Blumenthal JA, 2000, ARCH INTERN MED, V160, P1947, DOI 10.1001/archinte.160.13.1947
   Borges G, 2007, MOL NUTR FOOD RES, V51, P714, DOI 10.1002/mnfr.200700024
   Brader Lea, 2013, Rev Diabet Stud, V10, P270, DOI 10.1900/RDS.2013.10.270
   Bravo L, 1998, NUTR REV, V56, P317, DOI 10.1111/j.1753-4887.1998.tb01670.x
   Brownlee M, 2005, DIABETES, V54, P1615, DOI 10.2337/diabetes.54.6.1615
   Calò R, 2014, J PHOTOCH PHOTOBIO B, V132, P27, DOI 10.1016/j.jphotobiol.2014.01.013
   Cao GH, 1998, J NUTR, V128, P2383, DOI 10.1093/jn/128.12.2383
   Cao GH, 2001, AM J CLIN NUTR, V73, P920
   Cásedas G, 2018, FOOD CHEM TOXICOL, V118, P572, DOI 10.1016/j.fct.2018.05.066
   Chu WK., 2011, Herbal Medicine: Biomolecular and Clinical Aspects, V2nd, DOI DOI 10.1201/B10787-5
   Cignarella A, 1996, THROMB RES, V84, P311, DOI 10.1016/S0049-3848(96)00195-8
   Connor AM, 2002, J AGR FOOD CHEM, V50, P893, DOI 10.1021/jf011212y
   Cravotto G, 2010, J CLIN PHARM THER, V35, P11, DOI 10.1111/j.1365-2710.2009.01096.x
   Crozier A, 2009, NAT PROD REP, V26, P1001, DOI 10.1039/b802662a
   Dandona P, 2004, REV ENDOCR METAB DIS, V5, P189, DOI 10.1023/B:REMD.0000032407.88070.0a
   de Sales PM, 2012, J PHARM PHARM SCI, V15, P141
   Donath MY, 2011, NAT REV IMMUNOL, V11, P98, DOI 10.1038/nri2925
   Dos Santos JM, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/4189813
   Duthie SJ, 2006, EUR J NUTR, V45, P113, DOI 10.1007/s00394-005-0572-9
   Erlund I, 2008, AM J CLIN NUTR, V87, P323, DOI 10.1093/ajcn/87.2.323
   Fang J, 2014, DRUG METAB REV, V46, P508, DOI 10.3109/03602532.2014.978080
   Felgines C, 2003, J NUTR, V133, P1296
   Felgines C, 2002, J NUTR, V132, P1249, DOI 10.1093/jn/132.6.1249
   Freese R, 2004, EUR J NUTR, V43, P175, DOI 10.1007/s00394-004-0456-4
   Ginsberg HN, 2006, OBESITY, V14, p41S, DOI 10.1038/oby.2006.281
   Giugliano D, 1996, DIABETES CARE, V19, P257, DOI 10.2337/diacare.19.3.257
   Graf D, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0066690
   Han TS, 2016, JRSM CARDIOVASC DIS, V5, DOI 10.1177/2048004016633371
   Heyman L, 2014, J NUTR METAB, V2014, DOI 10.1155/2014/403041
   Hoggard N, 2013, J NUTR SCI, V2, DOI 10.1017/jns.2013.16
   Hurrle S, 2017, BIOMED J, V40, P257, DOI 10.1016/j.bj.2017.06.007
   Jakesevic M, 2011, BMC COMPLEM ALTERN M, V11, DOI 10.1186/1472-6882-11-8
   Jayaprakasam B, 2005, J AGR FOOD CHEM, V53, P28, DOI 10.1021/jf049018+
   Johansen JS, 2005, CARDIOVASC DIABETOL, V4, DOI 10.1186/1475-2840-4-5
   Kalt W, 1999, J AGR FOOD CHEM, V47, P4638, DOI 10.1021/jf990266t
   Karlsen A, 2007, J NUTR, V137, P1951
   Karlsen A, 2010, EUR J NUTR, V49, P345, DOI 10.1007/s00394-010-0092-0
   Khoo HE, 2017, FOOD NUTR RES, V61, P1, DOI 10.1080/16546628.2017.1361779
   Kim J, 2015, INT J FOOD SCI NUTR, V66, P236, DOI 10.3109/09637486.2014.979319
   Kolehmainen M, 2012, MOL NUTR FOOD RES, V56, P1501, DOI 10.1002/mnfr.201200195
   Kolosova NG, 2006, NEUROBIOL AGING, V27, P1289, DOI 10.1016/j.neurobiolaging.2005.07.022
   Kong JM, 2003, PHYTOCHEMISTRY, V64, P923, DOI 10.1016/S0031-9422(03)00438-2
   Kopp HP, 2005, INT J OBESITY, V29, P766, DOI 10.1038/sj.ijo.0802983
   Kowalczyk E, 2003, POL J PHARMACOL, V55, P699
   Larmo PS, 2013, AM J CLIN NUTR, V98, P941, DOI 10.3945/ajcn.113.060590
   Leopold Jane A, 2008, Drug Discov Today Ther Strateg, V5, P5, DOI 10.1016/j.ddstr.2008.02.001
   Libby P, 2002, CIRCULATION, V105, P1135, DOI 10.1161/hc0902.104353
   Libby P, 2018, J AM COLL CARDIOL, V72, P2071, DOI 10.1016/j.jacc.2018.08.1043
   Manach C, 2004, AM J CLIN NUTR, V79, P727, DOI 10.1093/ajcn/79.5.727
   Marczylo TH, 2009, CANCER CHEMOTH PHARM, V64, P1261, DOI 10.1007/s00280-009-0996-7
   Marniemi J, 2000, NUTR METAB CARDIOVAS, V10, P331
   Martineau LC, 2006, PHYTOMEDICINE, V13, P612, DOI 10.1016/j.phymed.2006.08.005
   Mazza G, 2002, J AGR FOOD CHEM, V50, P7731, DOI 10.1021/jf020690l
   McDougall GJ, 2008, BIOFACTORS, V34, P73, DOI 10.1002/biof.5520340108
   Monteiro R, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/289645
   Nath SD, 2005, JAMA-J AM MED ASSOC, V293, P2210, DOI 10.1001/jama.293.18.2210-b
   Nijhuis J, 2009, OBESITY, V17, P2014, DOI 10.1038/oby.2009.113
   Park SJ, 2007, FOOD CHEM TOXICOL, V45, P1459, DOI 10.1016/j.fct.2007.02.013
   Petlevski R, 2001, J ETHNOPHARMACOL, V75, P181, DOI 10.1016/S0378-8741(01)00177-5
   Piberger H, 2011, MOL NUTR FOOD RES, V55, P1724, DOI 10.1002/mnfr.201100380
   Podsedek A, 2014, J AGR FOOD CHEM, V62, P4610, DOI 10.1021/jf5008264
   Pojer E, 2013, COMPR REV FOOD SCI F, V12, P483, DOI 10.1111/1541-4337.12024
   Pravenec M, 2011, HYPERTENSION, V57, P731, DOI 10.1161/HYPERTENSIONAHA.110.164350
   Prior RL, 1998, J AGR FOOD CHEM, V46, P2686, DOI 10.1021/jf980145d
   Prior RL, 2006, FREE RADICAL RES, V40, P1014, DOI 10.1080/10715760600758522
   Qin Y, 2009, AM J CLIN NUTR, V90, P485, DOI 10.3945/ajcn.2009.27814
   Ridker PM, 2019, J INTERN MED, V285, P503, DOI 10.1111/joim.12862
   Ridker PM, 2019, CIRC RES, V124, P437, DOI 10.1161/CIRCRESAHA.118.313129
   Ridker PM, 2018, J AM COLL CARDIOL, V72, P3320, DOI 10.1016/j.jacc.2018.06.082
   Ridker PM, 2016, J AM COLL CARDIOL, V67, P712, DOI 10.1016/j.jacc.2015.11.037
   Ridker PM, 2016, CIRC RES, V118, P145, DOI 10.1161/CIRCRESAHA.115.306656
   Ridker PM, 2014, EUR HEART J, V35, P1782, DOI 10.1093/eurheartj/ehu203
   Sakakibara H, 2009, J AGR FOOD CHEM, V57, P7681, DOI 10.1021/jf901341b
   Seeram NP, 2008, J AGR FOOD CHEM, V56, P627, DOI 10.1021/jf071988k
   Sjöström CD, 1999, OBES RES, V7, P477
   Tajik N, 2013, J ENDOCRINOL INVEST, V36, P211, DOI 10.3275/8465
   Takikawa M, 2010, J NUTR, V140, P527, DOI 10.3945/jn.109.118216
   Tavafi M, 2011, TISSUE CELL, V43, P392, DOI 10.1016/j.tice.2011.09.001
   Triebel S, 2012, J AGR FOOD CHEM, V60, P8902, DOI 10.1021/jf3028842
   Ullah A, 2016, SAUDI PHARM J, V24, P547, DOI 10.1016/j.jsps.2015.03.013
   Upton R., 2001, Goldenseal root Hydrastis canadensis; Standards of analysis, quality control, and therapeutics
   Valentová K, 2007, FOOD CHEM, V101, P912, DOI 10.1016/j.foodchem.2006.02.038
   Veljkovic M, 2017, PHYTOTHER RES, V31, P115, DOI 10.1002/ptr.5738
   Wilson PWF, 2007, ARCH INTERN MED, V167, P1068, DOI 10.1001/archinte.167.10.1068
   Winefield C, 2009, Anthocyanins, VXVIII, P336, DOI [10.1007/978-0-387-77335-3, DOI 10.1007/978-0-387-77335-3]
   Yang Yaling, 2011, ISRN Cardiol, V2011, P397136, DOI 10.5402/2011/397136
   Zafra-Stone S, 2007, MOL NUTR FOOD RES, V51, P675, DOI 10.1002/mnfr.200700002
   Zhu Y, 2013, NUTR METAB CARDIOVAS, V23, P843, DOI 10.1016/j.numecd.2012.06.005
   Zhu YN, 2014, J CLIN ENDOCR METAB, V99, P561, DOI 10.1210/jc.2013-2845
   Zhu YN, 2011, CLIN CHEM, V57, P1524, DOI 10.1373/clinchem.2011.167361
   Ziccardi P, 2002, CIRCULATION, V105, P804, DOI 10.1161/hc0702.104279
NR 100
TC 28
Z9 28
U1 2
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD APR
PY 2020
VL 25
IS 7
AR 1653
DI 10.3390/molecules25071653
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA LL8VZ
UT WOS:000531833400178
PM 32260262
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nakyam, T
   Wattanathorn, J
   Thukham-mee, W
AF Nakyam, Thuntiva
   Wattanathorn, Jintanaporn
   Thukham-mee, Wipawee
TI Neuroprotective Effect of Polyherbal Recipe Containing Ginger, Chinese
   Date, and Wood Ear Mushroom against Ischemic Stroke with Metabolic
   Syndrome Condition via Epigenetic Modification of Inflammation and
   Oxidative Stress
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
AB Currently, the prevalence of stroke with metabolic syndrome (MetS) is increasing and the current therapeutic efficiency is still limited. Therefore, the applications of herbal recipes have gained much attention. The polyherbal recipe containing ginger, Chinese date, and wood ear mushroom is reputed for atherosclerosis and stroke prevention. It has been long-term consumed without scientific support. Therefore, this study was carried out to determine the neuroprotective effect and its mechanisms in animal model of ischemic stroke with MetS. Male Wistar rats weighing 180-220 g were exposed to a 16-week high-fat high-carbohydrate feeding. The rats with the MetS characteristic were exposed to a temporary occlusion of the right middle cerebral artery (MCAO) for 90 minutes. They were orally fed with the polyherbal recipe (GCJ) at the doses of 100, 200, and 300 mg/kg BW for 21 days and assessed the neurological deficit, ion volume, cortical neuron density in the cerebral cortex, oxidative stress status, inflammation, and expressions of histone deacetylase 3 (HDAC3) and DNA methyltransferase 1 (DNMT1). The results showed that GCJ significantly improved all mentioned parameters. Therefore, GCJ is the potential neuroprotectant against ischemic stroke with MetS. The underlying mechanisms may involve the reduction of oxidative stress, inflammation, and the modification of epigenetic mechanism via the reduction of HDAC3 and DNMT1. However, further clinical investigation is essential to confirm this positive modulation effect.
C1 [Nakyam, Thuntiva] Khon Kaen Univ, Dept Physiol, Khon Kaen 40002, Thailand.
   [Nakyam, Thuntiva] Khon Kaen Univ, Grad Sch, Neurosci Program, Fac Med, Khon Kaen 40002, Thailand.
   [Wattanathorn, Jintanaporn; Thukham-mee, Wipawee] Khon Kaen Univ, Res Inst Human High Performance & Hlth Prom, Khon Kaen 40002, Thailand.
   [Wattanathorn, Jintanaporn; Thukham-mee, Wipawee] Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
C3 Khon Kaen University; Khon Kaen University; Khon Kaen University; Khon
   Kaen University
RP Wattanathorn, J (corresponding author), Khon Kaen Univ, Res Inst Human High Performance & Hlth Prom, Khon Kaen 40002, Thailand.; Wattanathorn, J (corresponding author), Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
EM jinwat05@gmail.com
OI Thukhammee, Wipawee/0000-0001-6923-396X; Wattanathorn,
   Jintanaporn/0000-0002-7383-2348; Nakyam, Thuntiva/0000-0002-3835-6198
FU Thailand Science Research and Innovation (TSRI) through the Research and
   Researchers for Industries (RRI) project [PHD59I0036]; Agricultural
   Research Development Agency (ARDA); Integrative Complementary
   Alternative Medicine Research and Development Center in the Research
   Institute for Human High Performance and Health Promotion, Khon Kaen
   University, Khon Kaen, Thailand
FX The authors would like to express sincere gratitude to the Thailand
   Science Research and Innovation (TSRI) through the Research and
   Researchers for Industries (RRI) project (research no. PHD59I0036), the
   Agricultural Research Development Agency (ARDA), and the Integrative
   Complementary Alternative Medicine Research and Development Center in
   the Research Institute for Human High Performance and Health Promotion,
   Khon Kaen University, Khon Kaen, Thailand, for their supports.
CR Ali A, 2020, FRONT MOL NEUROSCI, V13, DOI 10.3389/fnmol.2020.00033
   Amani H, 2019, INT J NANOMED, V14, P8013, DOI 10.2147/IJN.S210035
   Asada M, 2020, FRONT NEUROSCI-SWITZ, V14, DOI 10.3389/fnins.2020.581915
   Bieber M, 2019, STROKE, V50, P2875, DOI 10.1161/STROKEAHA.119.026652
   Chen SC, 2021, FRONT CELL NEUROSCI, V15, DOI 10.3389/fncel.2021.716825
   Chen ZL, 2020, NEUROPSYCH DIS TREAT, V16, P2045, DOI 10.2147/NDT.S264300
   Endres M, 2001, NEUROREPORT, V12, P3763, DOI 10.1097/00001756-200112040-00032
   Endres M, 2000, J NEUROSCI, V20, P3175, DOI 10.1523/JNEUROSCI.20-09-03175.2000
   Fessler EB, 2013, CURR PHARM DESIGN, V19, P5105, DOI 10.2174/1381612811319280009
   Ghezzi AC, 2012, DIABETOL METAB SYNDR, V4, DOI 10.1186/1758-5996-4-16
   Keep RF, 2012, TRANSL STROKE RES, V3, P263, DOI 10.1007/s12975-012-0152-2
   Khafagy AT, 2019, EGYPT J NEUROL PSYCH, V55, DOI 10.1186/s41983-019-0099-2
   Krupinski J, 2018, COMPUT STRUCT BIOTEC, V16, P1, DOI 10.1016/j.csbj.2017.12.001
   Liao YJ, 2020, THERANOSTICS, V10, P9644, DOI 10.7150/thno.47651
   Livingston JM, 2020, NEUROBIOL DIS, V137, DOI 10.1016/j.nbd.2020.104756
   Lu H., 2022, Neuology, V98, P14
   Maiuolo J, 2021, FRONT CELL DEV BIOL, V9, DOI 10.3389/fcell.2021.651021
   Novelli ELB, 2007, LAB ANIM-UK, V41, P111, DOI 10.1258/002367707779399518
   Obadia N, 2017, BMC NEUROSCI, V18, DOI 10.1186/s12868-017-0384-x
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   Palachai N, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/5305437
   Palachai N, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/5972575
   Panchal SK, 2011, J CARDIOVASC PHARM, V57, P51, DOI [10.1097/FJC.0b013e3181feb90a, 10.1097/FJC.0b013e31821b1379]
   Panchal SK, 2011, J BIOMED BIOTECHNOL, DOI 10.1155/2011/351982
   Parasuraman Subramani, 2014, Pharmacogn Rev, V8, P73, DOI 10.4103/0973-7847.134229
   Park DJ, 2018, J VET MED SCI, V80, P676, DOI 10.1292/jvms.17-0693
   Rewell SSJ, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0171688
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Shah FA, 2019, FRONT NEUROL, V10, DOI 10.3389/fneur.2019.01178
   Shah FA, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.00663
   Shah FA, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.00297
   Shah FA, 2018, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00888
   Shah FA, 2016, J SURG RES, V201, P141, DOI 10.1016/j.jss.2015.10.025
   Sharifulina S, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222212483
   SUN Y, 1988, CLIN CHEM, V34, P497
   Uzdensky AB, 2021, NEURAL REGEN RES, V16, P1529, DOI 10.4103/1673-5374.303024
   Wang Y, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0060625
   Wattanathorn J, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/9658267
   Wattanathorn J, 2011, EVID-BASED COMPL ALT, V2011, P1, DOI 10.1155/2011/429505
   Xu YZ, 2020, DIS MARKERS, V2020, DOI 10.1155/2020/8820803
   Yang XY, 2016, FRONT MOL NEUROSCI, V9, DOI 10.3389/fnmol.2016.00131
   Yong-Quan G, 2018, THER ADV NEUROL DISO, V11, DOI 10.1177/1756286418771815
   Yu J, 2016, SCI REP-UK, V6, DOI 10.1038/srep30053
   Yu J, 2019, LAB ANIM-UK, V53, P478, DOI 10.1177/0023677218815210
   Zhang XH, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/8346301
   Zhao B, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/8520856
   Zhao HP, 2019, J CEREBR BLOOD F MET, V39, P2392, DOI 10.1177/0271678X19875201
NR 47
TC 2
Z9 2
U1 1
U2 2
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PD AUG 17
PY 2022
VL 2022
AR 8940303
DI 10.1155/2022/8940303
PG 14
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA VN4VZ
UT WOS:001153394200001
PM 39281061
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Nunes-Souza, V
   César-Gomes, CJ
   Da Fonseca, LJS
   Guedes, GD
   Smaniotto, S
   Rabelo, LA
AF Nunes-Souza, Valeria
   Cesar-Gomes, Cheila Juliana
   Sa Da Fonseca, Lucas Jose
   Guedes, Glaucevane Da Silva
   Smaniotto, Salete
   Rabelo, Luiza Antas
TI Aging Increases Susceptibility to High Fat Diet-Induced Metabolic
   Syndrome in C57BL/6 Mice: Improvement in Glycemic and Lipid Profile
   after Antioxidant Therapy
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID INCREASED OXIDATIVE STRESS; AIN-93 PURIFIED DIETS; INSULIN-RESISTANCE;
   ENDOTHELIAL DYSFUNCTION; NAD(P)H OXIDASE; HEPATIC STEATOSIS;
   LIVER-DISEASE; B DEGRADATION; GLUCOSE; RODENTS
AB Nonalcoholic fatty liver disease (NAFLD) has been considered a novel component of the metabolic syndrome (MetS), with the oxidative stress participating in its progression. This study aimed to evaluate the metabolic profile in young and old mice with MetS, and the effects of apocynin and tempol on glycemic and lipid parameters. Young and old C57BL/6 mice with high fat diet- (HFD-) induced MetS received apocynin and tempol 50 mg.kg(-1)/day in their drinking water for 10 weeks. After HFD, the young group showed elevated fasting glucose, worsened lipid profile in plasma, steatosis, and hepatic lipid peroxidation. Nevertheless, the old group presented significant increase in fasting insulin levels, insulin resistance, plasma and hepatic lipid peroxidation, and pronounced steatosis. The hepatic superoxide dismutase and catalase activity did not differ between the groups. Tempol and apocynin seemed to prevent hepatic lipid deposition in both groups. Furthermore, apocynin improved glucose tolerance and insulin sensitivity in old mice. In summary, old mice are more susceptible to HFD-induced metabolic changes than their young counterparts. Also, the antioxidant therapy improved insulin sensitivity and glucose tolerance, and in addition, apocynin seemed to prevent the HFD-induced hepatic fat deposition, suggesting an important role of oxidative stress in the induction of NAFLD.
C1 [Nunes-Souza, Valeria; Cesar-Gomes, Cheila Juliana; Sa Da Fonseca, Lucas Jose; Guedes, Glaucevane Da Silva; Rabelo, Luiza Antas] Univ Fed Alagoas UFAL, LRC, ICBS, Nucleo Sindrome Metab, Ave Lourival Melo Mota S-N,Cidade Univ, BR-57072900 Maceio, AL, Brazil.
   [Nunes-Souza, Valeria; Cesar-Gomes, Cheila Juliana; Sa Da Fonseca, Lucas Jose; Guedes, Glaucevane Da Silva; Rabelo, Luiza Antas] Natl Inst Sci & Technol Nanobiopharmaceut N BIOFA, Ave Antonio Carlos S-N, BR-31270901 Belo Horizonte, MG, Brazil.
   [Nunes-Souza, Valeria] Univ Fed Pernambuco UFPE, CCB, Dept Fisiol & Farmacol, Ave Prof Moraes Rego 1235,Cidade Univ, BR-50670901 Recife, PE, Brazil.
   [Guedes, Glaucevane Da Silva] Univ Fed Alagoas UFAL, Fac Nutr FANUT, Ave Lourival Melo Mota S-N,Cidade Univ, BR-57072900 Maceio, AL, Brazil.
   [Smaniotto, Salete] Univ Fed Alagoas UFAL, ICBS, Lab Biol Celular, Ave Lourival Melo Mota S-N,Cidade Univ, BR-57072900 Maceio, AL, Brazil.
   [Rabelo, Luiza Antas] Max Delbruck Ctr Mol Med, Robert Rossle Str 10, D-13125 Berlin, Germany.
C3 Universidade Federal de Pernambuco; Helmholtz Association; Max Delbruck
   Center for Molecular Medicine
RP Rabelo, LA (corresponding author), Univ Fed Alagoas UFAL, LRC, ICBS, Nucleo Sindrome Metab, Ave Lourival Melo Mota S-N,Cidade Univ, BR-57072900 Maceio, AL, Brazil.; Rabelo, LA (corresponding author), Natl Inst Sci & Technol Nanobiopharmaceut N BIOFA, Ave Antonio Carlos S-N, BR-31270901 Belo Horizonte, MG, Brazil.; Rabelo, LA (corresponding author), Max Delbruck Ctr Mol Med, Robert Rossle Str 10, D-13125 Berlin, Germany.
EM luizaa.rabelo@gmail.com
RI Smaniotto, Salete/AAT-4056-2020; Rabêlo, Luiza/S-4050-2019; Smaniotto,
   Salete/T-3796-2017
OI Smaniotto, Salete/0000-0003-1527-5894
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES;
   PROCAD-NF) [2450/2008]; Conselho Nacional de Desenvolvimento Cientifico
   e Tecnologico (CNPq) [483049/2009-3]; CNPq; FAPEAL; CAPES
FX The authors wish to thank Maria de Fatima Maia Sarmento and Delma Paes
   de Souza for their technical assistance during histology preparation and
   Iris Apostel-Krause for their assistance with the English revision of
   the paper. The authors wish to thank Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior (CAPES; PROCAD-NF 2450/2008) and Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq;
   483049/2009-3), for the financial support, and Professor Dr. Michael
   Bader and Dr. Natalia Alenina (Max Delbruck Center for Molecular
   Medicine, Berlin, Germany) for the donation of some reagents used during
   the assessment of the oxidative status. Valeria Nunes-Souza, Cheila
   Juliana Cesar-Gomes, and Lucas Jose Sa Da Fonseca received a Master's
   Scholarship from CNPq, FAPEAL, and CAPES, respectively.
CR Banday AA, 2005, DIABETES, V54, P2219, DOI 10.2337/diabetes.54.7.2219
   Basaranoglu M, 2013, WORLD J GASTROENTERO, V19, P1158, DOI 10.3748/wjg.v19.i8.1158
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Browning JD, 2004, J CLIN INVEST, V114, P147, DOI 10.1172/JCI200422422
   Collins AR, 2009, CIRC RES, V104, pe42, DOI 10.1161/CIRCRESAHA.108.188771
   den Boer M, 2004, ARTERIOSCL THROM VAS, V24, P644, DOI 10.1161/01.ATV.0000116217.57583.6e
   Dorman RB, 2006, AM J PHYSIOL-GASTR L, V290, pG1025, DOI 10.1152/ajpgi.00246.2005
   Dröge W, 2002, PHYSIOL REV, V82, P47, DOI 10.1152/physrev.00018.2001
   Espinosa A, 2013, INT J MOL SCI, V14, P15740, DOI 10.3390/ijms140815740
   Farrell GC, 2006, HEPATOLOGY, V43, pS99, DOI 10.1002/hep.20973
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   Fraulob JC, 2010, J CLIN BIOCHEM NUTR, V46, P212, DOI 10.3164/jcbn.09-83
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gastaldelli A, 2002, J CLIN ENDOCR METAB, V87, P5098, DOI 10.1210/jc.2002-020696
   Guerrero-Romero F, 2010, J CLIN ENDOCR METAB, V95, P3347, DOI 10.1210/jc.2010-0288
   Gupte AA, 2010, HEPATOLOGY, V52, P2001, DOI 10.1002/hep.23941
   Gupte S, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011800
   Ikeyama S, 2002, FASEB J, V16, pA1163, DOI 10.1096/fj.01-0409fje
   Kotronen A, 2008, ARTERIOSCL THROM VAS, V28, P27, DOI 10.1161/ATVBAHA.107.147538
   Lim K, 2013, HYPERTENSION, V61, P628, DOI 10.1161/HYPERTENSIONAHA.111.00705
   Lob HE, 2013, HYPERTENSION, V61, P382, DOI 10.1161/HYPERTENSIONAHA.111.00546
   Lu LS, 2007, LIVER INT, V27, P529, DOI 10.1111/j.1478-3231.2007.01451.x
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Meng R, 2011, ANN CLIN LAB SCI, V41, P236
   Meng R, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/858735
   Molnar J, 2005, CIRC RES, V96, P1178, DOI 10.1161/01.RES.0000168634.74330.ed
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   Pan MH, 2004, J CLIN INVEST, V113, P1277, DOI 10.1172/JCI200419197
   Pérez VI, 2009, BBA-GEN SUBJECTS, V1790, P1005, DOI 10.1016/j.bbagen.2009.06.003
   Polakof S, 2013, J NUTR BIOCHEM, V24, P1920, DOI 10.1016/j.jnutbio.2013.05.008
   Qureshi K, 2007, WORLD J GASTROENTERO, V13, P3540, DOI 10.3748/wjg.v13.i26.3540
   Rabêlo LA, 2010, ARQ BRAS CARDIOL, V94, P684, DOI 10.1590/S0066-782X2010000500018
   Raval J, 2006, FREE RADICAL BIO MED, V41, P1645, DOI 10.1016/j.freeradbiomed.2006.07.023
   REEVES PG, 1993, J NUTR, V123, P1923, DOI 10.1093/jn/123.11.1923
   REEVES PG, 1993, J NUTR, V123, P1939, DOI 10.1093/jn/123.11.1939
   Salmon AB, 2010, FREE RADICAL BIO MED, V48, P642, DOI 10.1016/j.freeradbiomed.2009.12.015
   Simental-Mendia Luis E., 2008, Metabolic Syndrome and Related Disorders, V6, P299, DOI 10.1089/met.2008.0034
   Sohal RS, 1996, SCIENCE, V273, P59, DOI 10.1126/science.273.5271.59
   Sone H, 2005, DIABETOLOGIA, V48, P58, DOI 10.1007/s00125-004-1605-2
   Sonta T, 2004, FREE RADICAL BIO MED, V37, P115, DOI 10.1016/j.freeradbiomed.2004.04.001
   Trott DW, 2011, J APPL PHYSIOL, V110, P1171, DOI 10.1152/japplphysiol.01037.2010
   Uchiyama S, 2006, J BIOL CHEM, V281, P31713, DOI 10.1074/jbc.M603422200
   Videla LA, 2004, CLIN SCI, V106, P261, DOI 10.1042/CS20030285
   Wanagat J, 1999, TOXICOL SCI, V52, P35
   Wilcox CS, 2010, PHARMACOL THERAPEUT, V126, P119, DOI 10.1016/j.pharmthera.2010.01.003
   Xu P, 2008, HYPERTENSION, V51, P574, DOI 10.1161/HYPERTENSIONAHA.107.102764
NR 47
TC 30
Z9 32
U1 0
U2 9
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2016
VL 2016
AR 1987960
DI 10.1155/2016/1987960
PG 17
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA DK4EG
UT WOS:000374869300001
PM 27057272
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Zhuo, Q
   Yang, W
   Chen, JY
   Wang, Y
AF Zhuo, Qi
   Yang, Wei
   Chen, Jiying
   Wang, Yan
TI Metabolic syndrome meets osteoarthritis
SO NATURE REVIEWS RHEUMATOLOGY
LA English
DT Review
ID GLYCATION END-PRODUCTS; NITRIC-OXIDE SYNTHASE; DEPENDENT
   DIABETES-MELLITUS; 3RD NATIONAL-HEALTH; BODY-MASS INDEX; FACTOR-KAPPA-B;
   KNEE OSTEOARTHRITIS; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE;
   RADIOGRAPHIC OSTEOARTHRITIS
AB Metabolic osteoarthritis (OA) has now been characterized as a subtype of OA, and links have been discovered between this phenotype and metabolic syndrome (MetS)-both with individual MetS components and with MetS as a whole. Hypertension associates with OA through subchondral ischaemia, which can compromise nutrient exchange into articular cartilage and trigger bone remodelling. Ectopic lipid deposition in chondrocytes induced by dyslipidemia might initiate OA development, exacerbated by deregulated cellular lipid metabolism in joint tissues. Hyperglycaemia and OA interact at both local and systemic levels; local effects of oxidative stress and advanced glycation end-products are implicated in cartilage damage, whereas low-grade systemic inflammation results from glucose accumulation and contributes to a toxic internal environment that can exacerbate OA. Obesity-related metabolic factors, particularly altered levels of adipokines, contribute to OA development by inducing the expression of proinflammatory factors as well as degradative enzymes, leading to the inhibition of cartilage matrix synthesis and stimulation of subchondral bone remodelling. In this Review, we summarize the shared mechanisms of inflammation, oxidative stress, common metabolites and endothelial dysfunction that characterize the aetiologies of OA and MetS, and nominate metabolic OA as the fifth component of MetS. We also describe therapeutic opportunities that might arise from uniting these concepts. Zhuo, Q. et al. Nat. Rev. Rheumatol. 8, 729-737 (2012); published online 21 August 2012; doi:10.1038/nrrheum.2012.135
C1 [Zhuo, Qi; Chen, Jiying; Wang, Yan] Chinese Peoples Liberat Army Gen Hosp, Dept Orthopaed, Beijing 100853, Peoples R China.
   [Yang, Wei] Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing 100853, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Chinese People's
   Liberation Army General Hospital
RP Wang, Y (corresponding author), Chinese Peoples Liberat Army Gen Hosp, Dept Orthopaed, Fuxing Rd 28, Beijing 100853, Peoples R China.
EM yannwang301@yahoo.com
CR Al-Arfaj AS, 2003, SAUDI MED J, V24, P745
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   ALTMAN R, 1986, ARTHRITIS RHEUM-US, V29, P1039, DOI 10.1002/art.1780290816
   Anagnostis P, 2010, CURR VASC PHARMACOL, V8, P720, DOI 10.2174/157016110792006978
   ANDERSON JJ, 1988, AM J EPIDEMIOL, V128, P179, DOI 10.1093/oxfordjournals.aje.a114939
   Anitua E., 2009, INT J RHEUMATOL, V2009, DOI DOI 10.1155/2009/747432
   Aspden RM, 2011, NAT REV RHEUMATOL, V7, P65, DOI 10.1038/nrrheum.2010.123
   Aspden RM, 2001, LANCET, V357, P1118, DOI 10.1016/S0140-6736(00)04264-1
   Baker JF, 2011, JOINT BONE SPINE, V78, P31, DOI 10.1016/j.jbspin.2010.02.035
   Balkau B, 1999, DIABETIC MED, V16, P442
   Beattie MS, 2005, J RHEUMATOL, V32, P106
   Bedard K, 2007, PHYSIOL REV, V87, P245, DOI 10.1152/physrev.00044.2005
   Bell AC, 2002, AM J EPIDEMIOL, V155, P346, DOI 10.1093/aje/155.4.346
   Berenbaum F, 2011, ANN RHEUM DIS, V70, P1354, DOI 10.1136/ard.2010.146399
   Berger CE, 2003, BONE, V33, P346, DOI 10.1016/S8756-3282(03)00164-9
   Bergink AP, 2009, JCR-J CLIN RHEUMATOL, V15, P230, DOI 10.1097/RHU.0b013e3181b08f20
   Bijlsma JWJ, 2011, LANCET, V377, P2115, DOI 10.1016/S0140-6736(11)60243-2
   Boileau C, 2009, ARTHRITIS RES THER, V11, DOI 10.1186/ar2649
   Bokarewa M, 2005, J IMMUNOL, V174, P5789, DOI 10.4049/jimmunol.174.9.5789
   Brown CD, 2000, OBES RES, V8, P605, DOI 10.1038/oby.2000.79
   Cardona F, 2008, EUR J CLIN INVEST, V38, P510, DOI 10.1111/j.1365-2362.2008.01959.x
   Cecil DL, 2005, J IMMUNOL, V175, P8296, DOI 10.4049/jimmunol.175.12.8296
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Chaganti RK, 2010, ARTHRITIS RHEUM-US, V62, P511, DOI 10.1002/art.27241
   Chen NX, 2003, BONE, V33, P399, DOI 10.1016/S8756-3282(03)00159-5
   Chen TH, 2006, BBA-MOL BASIS DIS, V1762, P711, DOI 10.1016/j.bbadis.2006.06.008
   Chowdhury TT, 2008, ARTHRITIS RES THER, V10, DOI 10.1186/ar2389
   CIMMINO MA, 1990, CLIN EXP RHEUMATOL, V8, P251
   Clockaerts S, 2012, ANN RHEUM DIS, V71, P642, DOI 10.1136/annrheumdis-2011-200092
   Collins-Racie LA, 2009, OSTEOARTHR CARTILAGE, V17, P832, DOI 10.1016/j.joca.2008.12.011
   Conaghan PG, 2005, ANN RHEUM DIS, V64, P1539, DOI 10.1136/ard.2005.039263
   Devaraj S., 2008, Diabetes Pathophysiology, P32, DOI [10.17925/USE.2008.04.2.32, DOI 10.17925/USE.2008.04.2.32]
   Dimmeler S, 1999, NATURE, V399, P601, DOI 10.1038/21224
   Dumond H, 2003, ARTHRITIS RHEUM, V48, P3118, DOI 10.1002/art.11303
   Ehling A, 2006, J IMMUNOL, V176, P4468, DOI 10.4049/jimmunol.176.7.4468
   Empana JP, 2008, EUR HEART J, V29, P1221, DOI 10.1093/eurheartj/ehn185
   Engström G, 2009, OSTEOARTHR CARTILAGE, V17, P168, DOI 10.1016/j.joca.2008.07.003
   Faggioni R, 2001, FASEB J, V15, P2565, DOI 10.1096/fj.01-0431rev
   Fahmi H, 2011, MOD RHEUMATOL, V21, P1, DOI 10.1007/s10165-010-0347-x
   Felmeden DC, 2003, AM J HYPERTENS, V16, P11, DOI 10.1016/S0895-7061(02)03149-7
   FELSON DT, 1988, ANN INTERN MED, V109, P18, DOI 10.7326/0003-4819-109-1-18
   Filková M, 2009, ANN RHEUM DIS, V68, P295, DOI 10.1136/ard.2008.095737
   Findlay DM, 2007, RHEUMATOLOGY, V46, P1763, DOI 10.1093/rheumatology/kem191
   Fitzgerald JB, 2008, J BIOL CHEM, V283, P6735, DOI 10.1074/jbc.M708670200
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Fortuño A, 2006, DIABETES, V55, P209, DOI 10.2337/diabetes.55.1.209
   Frey MI, 1996, J RHEUMATOL, V23, P716
   Frommer K. W., ANN RHEUM DIS
   Fulton D, 1999, NATURE, V399, P597, DOI 10.1038/21218
   Gabay O, 2008, OSTEOARTHR CARTILAGE, V16, P373, DOI 10.1016/j.joca.2007.06.016
   Gabay O, 2008, JOINT BONE SPINE, V75, P675, DOI 10.1016/j.jbspin.2008.07.011
   Gimbrone MA, 2000, ANN NY ACAD SCI, V902, P230
   Gkretsi V, 2011, PROG LIPID RES, V50, P133, DOI 10.1016/j.plipres.2010.11.001
   Gobezie R, 2007, ARTHRITIS RES THER, V9, DOI 10.1186/ar2172
   Gomes VA, 2008, NITRIC OXIDE-BIOL CH, V19, P345, DOI 10.1016/j.niox.2008.08.005
   Gómez R, 2011, NAT REV RHEUMATOL, V7, P528, DOI 10.1038/nrrheum.2011.107
   Gomez R, 2009, J MOL ENDOCRINOL, V43, P11, DOI 10.1677/JME-08-0131
   Gonzalez-Gay MA, 2008, CLIN EXP RHEUMATOL, V26, P311
   Gosset M, 2006, ARTHRITIS RES THER, V8, DOI 10.1186/ar2024
   Griffin TM, 2009, ARTHRITIS RHEUM-US, V60, P2935, DOI 10.1002/art.24854
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Gupta K, 2007, ARTHRITIS RHEUM-US, V56, P3326, DOI 10.1002/art.22879
   Hamerman D, 1996, J BONE MINER RES, V11, P1205
   Hao DS, 2011, RHEUMATOL INT, V31, P1433, DOI 10.1007/s00296-010-1516-0
   HART DJ, 1995, J RHEUMATOL, V22, P1118
   Henrotin YE, 2003, OSTEOARTHR CARTILAGE, V11, P747, DOI 10.1016/S1063-4584(03)00150-X
   Hiraiwa H, 2011, INFLAMM RES, V60, P1039, DOI 10.1007/s00011-011-0365-y
   Hoeven T. A., ANN RHEUM DIS
   Honsawek S, 2010, ARCH MED RES, V41, P593, DOI 10.1016/j.arcmed.2010.11.007
   Horie T, 2008, J LIPID RES, V49, P1224, DOI 10.1194/jlr.M700578-JLR200
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Huang PL, 2005, CIRC RES, V96, P1129, DOI 10.1161/01.RES.0000170705.56583.45
   Huffman KM, 2012, OSTEOARTHR CARTILAGE, V20, P603, DOI 10.1016/j.joca.2012.04.007
   Hurley MV, 1999, RHEUM DIS CLIN N AM, V25, P283, DOI 10.1016/S0889-857X(05)70068-5
   Ibrahim MM, 2010, OBES REV, V11, P11, DOI 10.1111/j.1467-789X.2009.00623.x
   Iliopoulos D, 2007, ANN RHEUM DIS, V66, P1616, DOI 10.1136/ard.2007.069377
   Iliopoulos D, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003740
   Imhof H, 2000, INVEST RADIOL, V35, P581, DOI 10.1097/00004424-200010000-00004
   Inoue D, 2004, J BIOL CHEM, V279, P49795, DOI 10.1074/jbc.M404096200
   Jonsson H, 2009, ANN RHEUM DIS, V68, P1696, DOI 10.1136/ard.2008.096289
   Jonsson H, 2011, ANN RHEUM DIS, V70, P1087, DOI 10.1136/ard.2010.144980
   Jouzeau Jean-Yves, 2008, Journal de la Societe de Biologie, V202, P289, DOI 10.1051/jbio:2008034
   Karter Y, 2004, J HUM HYPERTENS, V18, P809, DOI 10.1038/sj.jhh.1001752
   Karvonen-Gutierrez CA, 2012, OSTEOARTHR CARTILAGE, V20, P614, DOI 10.1016/j.joca.2012.02.644
   Kellgren J. H., 1961, BRIT MED J, V2, P1
   Kerachian MA, 2011, J ORTHOP SURG RES, V6, DOI 10.1186/1749-799X-6-62
   Kiefer FN, 2003, CURR PHARM DESIGN, V9, P1733, DOI 10.2174/1381612033454540
   Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213
   Kim MK, 2010, CLIN ENDOCRINOL, V73, P330, DOI 10.1111/j.1365-2265.2010.03798.x
   Korochina IE, 2007, TERAPEVT ARKH, V79, P13
   Lago R, 2008, OSTEOARTHR CARTILAGE, V16, P1101, DOI 10.1016/j.joca.2007.12.008
   Lajeunesse D., 2002, Journal of Musculoskeletal & Neuronal Interactions, V2, P504
   Laurberg TB, 2009, J RHEUMATOL, V36, P1885, DOI 10.3899/jrheum.080907
   Lee SW, 2008, SCAND J RHEUMATOL, V37, P260, DOI 10.1080/03009740801910346
   LIPPIELLO L, 1991, METABOLISM, V40, P571, DOI 10.1016/0026-0495(91)90046-Y
   Liu FC, 2011, J CLIN IMMUNOL, V31, P1131, DOI 10.1007/s10875-011-9576-9
   Liu J, 2006, BIOCHEM BIOPH RES CO, V348, P1167, DOI 10.1016/j.bbrc.2006.07.175
   Loeser RF, 2005, ARTHRITIS RHEUM, V52, P2376, DOI 10.1002/art.21199
   Maleki-Fischbach M, 2010, ARTHRITIS RES THER, V12, DOI 10.1186/ar3091
   Marks Ray, 2002, Med Sci Monit, V8, pCR305
   Marok R, 1996, ARTHRITIS RHEUM, V39, P583, DOI 10.1002/art.1780390407
   McNulty AL, 2005, ARTHRITIS RHEUM-US, V52, P2676, DOI 10.1002/art.21254
   Mendel' O I, 2010, Adv Gerontol, V23, P304
   Miller D, 2007, J APPL PHYSIOL, V102, P1161, DOI 10.1152/japplphysiol.00209.2006
   Motyl K. J., BIOCHIMIE
   Mutabaruka MS, 2010, ARTHRITIS RES THER, V12, DOI 10.1186/ar2925
   Nah SS, 2008, RHEUMATOLOGY, V47, P425, DOI 10.1093/rheumatology/kem376
   Nah SS, 2007, FEBS LETT, V581, P1928, DOI 10.1016/j.febslet.2007.03.090
   Nakano Y, 2006, J LIPID RES, V47, P1572, DOI 10.1194/jlr.D600010-JLR200
   Oliviero F, 2009, CLIN EXP RHEUMATOL, V27, P79
   Otero M, 2003, ARTHRITIS RHEUM, V48, P404, DOI 10.1002/art.10811
   Parker J, 2010, MATURITAS, V65, P225, DOI 10.1016/j.maturitas.2009.12.013
   Patel SB, 2008, CURR HYPERTENS REP, V10, P131, DOI 10.1007/s11906-008-0025-y
   Philbin E F, 1996, J Cardiovasc Risk, V3, P529, DOI 10.1097/00043798-199612000-00008
   Pottie P, 2006, ANN RHEUM DIS, V65, P1403, DOI 10.1136/ard.2006.061994
   Puenpatom RA, 2009, POSTGRAD MED, V121, P9, DOI 10.3810/pgm.2009.11.2073
   Rasheed Z, 2011, RHEUMATOLOGY, V50, P838, DOI 10.1093/rheumatology/keq380
   Ruiz-Romero C, 2005, PROTEOMICS, V5, P3048, DOI 10.1002/pmic.200402106
   Sanchez C, 2012, ARTHRITIS RHEUM-US, V64, P1193, DOI 10.1002/art.33445
   Sanna V, 2003, J CLIN INVEST, V111, P241, DOI 10.1172/JCI200316721
   Schett G, 2009, ARTHRITIS RHEUM-US, V60, P2381, DOI 10.1002/art.24757
   Senolt L, 2007, ANN RHEUM DIS, V66, P458, DOI 10.1136/ard.2006.054734
   Shakoor N, 2008, ARTHRIT RHEUM-ARTHR, V59, P1237, DOI 10.1002/art.24004
   Shibahara M, 2000, ACTA MED OKAYAMA, V54, P67
   Shimazaki A, 2006, BIORHEOLOGY, V43, P223
   Simopoulou T, 2007, CLIN EXP RHEUMATOL, V25, P605
   Singh G, 2002, AM J MANAG CARE, V8, pS383
   Slemenda C, 1997, ANN INTERN MED, V127, P97, DOI 10.7326/0003-4819-127-2-199707150-00001
   Sowers M, 2009, ARTHRIT CARE RES, V61, P1328, DOI 10.1002/art.24739
   Sowers MR, 2006, ARTHRITIS RHEUM-US, V54, P2481, DOI 10.1002/art.22005
   Sowers MR, 2010, CURR OPIN RHEUMATOL, V22, P533, DOI 10.1097/BOR.0b013e32833b4682
   Stannus O, 2010, OSTEOARTHR CARTILAGE, V18, P1441, DOI 10.1016/j.joca.2010.08.016
   Steenvoorden MMC, 2006, ARTHRITIS RHEUM-US, V54, P253, DOI 10.1002/art.21523
   Stürmer T, 1998, J RHEUMATOL, V25, P1827
   Stürmer T, 2001, SCAND J RHEUMATOL, V30, P169
   Symmons D., 2003, GLOBAL BURDEN OSTEOA
   Tsezou A, 2010, J ORTHOP RES, V28, P1033, DOI 10.1002/jor.21084
   Urakawa H, 2003, J CLIN ENDOCR METAB, V88, P4673, DOI 10.1210/jc.2003-030202
   Vallon R, 2001, J IMMUNOL, V166, P2801, DOI 10.4049/jimmunol.166.4.2801
   Velasquez MT, 2010, METAB SYNDR RELAT D, V8, P295, DOI 10.1089/met.2009.0110
   WAINE H, 1961, Tufts Folia Med, V7, P13
   Wu J, 2007, ARTHRITIS RHEUM-US, V56, P3675, DOI 10.1002/art.22876
   Wu QQ, 2008, ARTHRITIS RHEUM-US, V58, P3132, DOI 10.1002/art.23946
   Yammani RR, 2006, ARTHRITIS RHEUM-US, V54, P2901, DOI 10.1002/art.22042
   Yoshimura N, 2011, J RHEUMATOL, V38, P921, DOI 10.3899/jrheum.100569
   Yudoh K, 2010, AGING-US, V2, P990, DOI 10.18632/aging.100213
   ZHANG YY, 1994, NATURE, V372, P425, DOI 10.1038/372425a0
   Zimmet P, 2005, J ATHEROSCLER THROMB, V12, P295, DOI 10.5551/jat.12.295
   Ziskoven C, 2010, ORTHOP REV, V2, P95, DOI 10.4081/or.2010.e23
NR 149
TC 433
Z9 477
U1 1
U2 118
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1759-4790
EI 1759-4804
J9 NAT REV RHEUMATOL
JI Nat. Rev. Rheumatol.
PD DEC
PY 2012
VL 8
IS 12
BP 729
EP 737
DI 10.1038/nrrheum.2012.135
PG 9
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 051LO
UT WOS:000312128600007
PM 22907293
DA 2025-06-11
ER

PT J
AU Tam, E
   Sweeney, G
AF Tam, Eddie
   Sweeney, Gary
TI MitoNEET Provides Cardioprotection via Reducing Oxidative Damage and
   Conserving Mitochondrial Function
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE mitoNEET; mitochondria; iron metabolism; oxidative stress;
   cardiometabolic disease
ID MEMBRANE PROTEIN; GLOBAL BURDEN; DISEASE; STRESS; HEART; IDENTIFICATION;
   FERROPTOSIS; DYSFUNCTION; TT01001
AB Cardiometabolic diseases exert a significant health impact, leading to a considerable economic burden globally. The metabolic syndrome, characterized by a well-defined cluster of clinical parameters, is closely linked to an elevated risk of cardiovascular disease. Current treatment strategies often focus on addressing individual aspects of metabolic syndrome. We propose that exploring novel therapeutic approaches that simultaneously target multiple facets may prove more effective in alleviating the burden of cardiometabolic disease. There is a growing body of evidence suggesting that mitochondria can serve as a pivotal target for the development of therapeutics aimed at resolving both metabolic and vascular dysfunction. MitoNEET was identified as a binding target for the thiazolidinedione (TZD) class of antidiabetic drugs and is now recognized for its role in regulating various crucial cellular processes. Indeed, mitoNEET has demonstrated promising potential as a therapeutic target in various chronic diseases, encompassing cardiovascular and metabolic diseases. In this review, we present a thorough overview of the molecular mechanisms of mitoNEET, with an emphasis on their implications for cardiometabolic diseases in more recent years. Furthermore, we explore the potential impact of these findings on the development of novel therapeutic strategies and discuss potential directions for future research.
C1 [Tam, Eddie; Sweeney, Gary] York Univ, Dept Biol, Toronto, ON M3J 1P3, Canada.
C3 York University - Canada
RP Sweeney, G (corresponding author), York Univ, Dept Biol, Toronto, ON M3J 1P3, Canada.
EM gsweeney@yorku.ca
OI Tam, Eddie/0009-0002-8480-7145
FU National Science and Engineering Research Council
FX No Statement Available
CR Ayer A, 2022, FREE RADICAL BIO MED, V179, P339, DOI 10.1016/j.freeradbiomed.2021.11.007
   Bak DW, 2009, BIOCHEMISTRY-US, V48, P10193, DOI 10.1021/bi9016445
   Barteková M, 2021, FREE RADICAL BIO MED, V169, P446, DOI 10.1016/j.freeradbiomed.2021.03.045
   Batista-Jorge GC, 2020, LIFE SCI, V256, DOI 10.1016/j.lfs.2020.117962
   Boos JR, 2022, ADV REDOX RES, V6, DOI 10.1016/j.arres.2022.100048
   Butrous H, 2016, CAN J CARDIOL, V32, P1140, DOI 10.1016/j.cjca.2016.05.005
   Chang HC, 2016, CIRC RES, V119, P1164, DOI 10.1161/CIRCRESAHA.116.309746
   Chang HC, 2016, EMBO MOL MED, V8, P247, DOI 10.15252/emmm.201505748
   Chang L, 2018, CARDIOVASC DRUG THER, V32, P531, DOI 10.1007/s10557-018-6809-7
   Charron MJ, 2020, DIABETES, V69, P1650, DOI 10.2337/db19-1129
   Chen XY, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/9817576
   Chew NWS, 2023, CELL METAB, V35, P414, DOI 10.1016/j.cmet.2023.02.003
   Chong BY, 2023, METABOLISM, V141, DOI 10.1016/j.metabol.2023.155402
   Cilibrizzi A, 2023, BIOMETALS, V36, P321, DOI 10.1007/s10534-022-00383-8
   Colca JR, 2004, AM J PHYSIOL-ENDOC M, V286, pE252, DOI 10.1152/ajpendo.00424.2003
   Cunnington C, 2012, CIRCULATION, V125, P1356, DOI 10.1161/CIRCULATIONAHA.111.038919
   Danielpur L, 2016, J CLIN ENDOCR METAB, V101, P3592, DOI 10.1210/jc.2016-2240
   Dhani S, 2021, CELL DEATH DIS, V12, DOI 10.1038/s41419-021-04240-3
   Dludla PV, 2018, AM J CARDIOVASC DRUG, V18, P283, DOI 10.1007/s40256-018-0275-2
   Duan GY, 2023, MOLECULES, V28, DOI 10.3390/molecules28010029
   Fang XX, 2023, NAT REV CARDIOL, V20, P7, DOI 10.1038/s41569-022-00735-4
   Ferecatu I, 2014, J BIOL CHEM, V289, P28070, DOI 10.1074/jbc.M114.548438
   Forman HJ, 2021, NAT REV DRUG DISCOV, V20, P689, DOI 10.1038/s41573-021-00233-1
   Furihata T, 2021, COMMUN BIOL, V4, DOI 10.1038/s42003-021-01675-4
   Geldenhuys WJ, 2017, ACS CHEM NEUROSCI, V8, P2759, DOI 10.1021/acschemneuro.7b00287
   Guembe MJ, 2020, CARDIOVASC DIABETOL, V19, DOI 10.1186/s12933-020-01166-6
   Guerra F, 2017, BIOMED RES INT, V2017, DOI 10.1155/2017/1483873
   Habener A, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0156054
   Hashimoto H, 2018, NAT REV CARDIOL, V15, P585, DOI 10.1038/s41569-018-0036-6
   Inupakutika MA, 2017, SCI REP-UK, V7, DOI 10.1038/srep42571
   Jahng JWS, 2016, EXP MOL MED, V48, DOI 10.1038/emm.2016.20
   Janaszak-Jasiecka A, 2023, CELL MOL BIOL LETT, V28, DOI 10.1186/s11658-023-00423-2
   Kusminski CM, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4962
   Kusminski CM, 2012, NAT MED, V18, P1539, DOI 10.1038/nm.2899
   Landry AP, 2014, J BIOL CHEM, V289, P4307, DOI 10.1074/jbc.M113.542050
   Lebovitz HE, 2019, CURR DIABETES REP, V19, DOI 10.1007/s11892-019-1270-y
   Lee S, 2022, BMB REP, V55, P354, DOI 10.5483/BMBRep.2022.55.7.040
   Lin HY, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/7514383
   Liu L, 2023, J BIOMED SCI, V30, DOI 10.1186/s12929-023-00975-7
   Logan SJ, 2015, BASIC RES CARDIOL, V110, DOI 10.1007/s00395-015-0471-z
   MacRae CA, 2016, CIRCULATION, V133, P2610, DOI 10.1161/CIRCULATIONAHA.116.023555
   Mirmiran P, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-05632-x
   Mobarra Naser, 2016, Int J Hematol Oncol Stem Cell Res, V10, P239
   Moe GW, 2016, HEART FAIL REV, V21, P157, DOI 10.1007/s10741-016-9532-0
   Mons C, 2018, BIOCHEMISTRY-US, V57, P5616, DOI 10.1021/acs.biochem.8b00777
   Moris D, 2017, ANN TRANSL MED, V5, DOI 10.21037/atm.2017.06.27
   Mughal A, 2015, EUR J PHARMACOL, V768, P217, DOI 10.1016/j.ejphar.2015.10.057
   Murphy MP, 2018, NAT REV DRUG DISCOV, V17, P865, DOI 10.1038/nrd.2018.174
   Nair N, 2020, BBA-MOL BASIS DIS, V1866, DOI 10.1016/j.bbadis.2019.06.003
   Ning P, 2022, FRONT PHYSIOL, V13, DOI 10.3389/fphys.2022.957968
   Peoples JN, 2019, EXP MOL MED, V51, DOI 10.1038/s12276-019-0355-7
   Qi XY, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0777-x
   Qi YB, 2023, TOXICOL APPL PHARM, V465, DOI 10.1016/j.taap.2023.116440
   Roberts ME, 2013, BIOCHEMISTRY-US, V52, P8969, DOI 10.1021/bi401038w
   Roth GA, 2020, J AM COLL CARDIOL, V76, P2982, DOI 10.1016/j.jacc.2020.11.010
   Saralkar P, 2021, PHARM RES-DORDR, V38, P803, DOI 10.1007/s11095-021-03046-4
   Saralkar P, 2020, INT J PHARMACEUT, V578, DOI 10.1016/j.ijpharm.2020.119090
   Sergi D, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00532
   Shi GY, 2020, NEUROREPORT, V31, P845, DOI 10.1097/WNR.0000000000001492
   Sies H, 2020, NAT REV MOL CELL BIO, V21, P363, DOI 10.1038/s41580-020-0230-3
   Stockwell BR, 2022, CELL, V185, P2401, DOI 10.1016/j.cell.2022.06.003
   Takahashi T, 2015, J PHARMACOL EXP THER, V352, P338, DOI 10.1124/jpet.114.220673
   Tam E, 2023, J CELL PHYSIOL, V238, P1867, DOI 10.1002/jcp.31044
   Tam E, 2023, CELLS-BASEL, V12, DOI 10.3390/cells12010118
   Vernay A, 2017, P NATL ACAD SCI USA, V114, P8277, DOI 10.1073/pnas.1706643114
   Wang JS, 2023, JAMA NETW OPEN, V6, DOI 10.1001/jamanetworkopen.2023.2145
   Wang ZG, 2022, PHARMACOL RES, V178, DOI 10.1016/j.phrs.2022.106183
   Wiley SE, 2007, J BIOL CHEM, V282, P23745, DOI 10.1074/jbc.C700107200
   Wiley SE, 2007, P NATL ACAD SCI USA, V104, P5318, DOI 10.1073/pnas.0701078104
   Wilkinson N, 2014, FRONT PHARMACOL, V5, DOI 10.3389/fphar.2014.00176
   Wilson DF, 2018, J APPL PHYSIOL, V125, P419, DOI 10.1152/japplphysiol.01077.2017
   Xiong WH, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.01032
   Xu T, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/9030563
   Yarema M, 2018, J MED TOXICOL, V14, P120, DOI 10.1007/s13181-018-0653-9
   Yaribeygi H, 2019, J CELL PHYSIOL, V234, P8402, DOI 10.1002/jcp.27754
   Yonutas HM, 2020, EXP NEUROL, V327, DOI 10.1016/j.expneurol.2020.113243
   Yuan H, 2016, BIOCHEM BIOPH RES CO, V478, P838, DOI 10.1016/j.bbrc.2016.08.034
   Zhu L, 2020, J CLIN MED, V9, DOI 10.3390/jcm9123871
NR 78
TC 6
Z9 6
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2024
VL 25
IS 1
AR 480
DI 10.3390/ijms25010480
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA ER3D8
UT WOS:001140602500001
PM 38203651
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU de Franca, E
   dos Santos, RVT
   Baptista, LC
   Da Silva, MAR
   Fukushima, AR
   Hirota, VB
   Martins, RA
   Caperuto, EC
AF de Franca, Elias
   dos Santos, Ronaldo V. T.
   Baptista, Liliana C.
   Da Silva, Marco A. R.
   Fukushima, Andre R.
   Hirota, Vinicius B.
   Martins, Raul A.
   Caperuto, Erico C.
TI Potential Role of Chronic Physical Exercise as a Treatment in the
   Development of Vitiligo
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE vitiligo; autoimmune disease; physical training; immune system;
   oxidative stress; metabolic syndrome
ID BLOOD MONONUCLEAR-CELLS; CD8(+) T-CELLS; OXIDATIVE STRESS; METABOLIC
   SYNDROME; MELANOCYTE DEGENERATION; AUTOIMMUNE-DISEASES;
   CALCIUM-TRANSPORT; GENETIC-VARIANTS; IMMUNE-RESPONSE; IFN-GAMMA
AB Vitiligo is an autoimmune disease characterized by progressive skin depigmentation and the appearance of white patches throughout the body caused by significant apoptosis of epidermal melanocytes. Despite not causing any physical pain, vitiligo can originate several psychosocial disorders, drastically reducing patients' quality of life. Emerging evidence has shown that vitiligo is associated with several genetic polymorphisms related to auto-reactivity from the immune system to melanocytes. Melanocytes from vitiligo patients suffer from excess reactive oxygen species (ROS) produced by defective mitochondria besides a poor endogenous antioxidant system (EAS). This redox imbalance results in dramatic melanocyte oxidative stress (OS), causing significant damage in proteins, lipid membranes, and DNA. The damaged melanocytes secret damage-associated molecular pattern (DAMPs), inducing and increasing inflammatory gene expression response that ultimately leads to melanocytes apoptosis. Vitiligo severity has been also associated with increasing the prevalence and incidence of metabolic syndrome (MetS) or associated disorders such as insulin resistance and hypercholesterolemia. Thus, suggesting that in genetically predisposed individuals, the environmental context that triggers MetS (i.e., sedentary lifestyle) may also be an important trigger for the development and severity of vitiligo disease. This paper will discuss the relationship between the immune system and epidermal melanocytes and their interplay with the redox system. Based on state-of-the-art evidence from the vitiligo research, physical exercise (PE) immunology, and redox system literature, we will also propose chronic PE as a potential therapeutic strategy to treat and prevent vitiligo disease progression. We will present evidence that chronic PE can change the balance of inflammatory to an anti-inflammatory state, improve both EAS and the mitochondrial structure and function (resulting in the decrease of OS). Finally, we will highlight clinically relevant markers that can be analyzed in a new research avenue to test the potential applicability of chronic PE in vitiligo disease.
C1 [de Franca, Elias; Caperuto, Erico C.] Sao Judas Univ, Human Movement Lab, Sao Paulo, Brazil.
   [de Franca, Elias; dos Santos, Ronaldo V. T.] Univ Fed Sao Paulo, Dept Biociencias, Sao Paulo, Brazil.
   [Baptista, Liliana C.] Univ Porto, Fac Sport, Res Ctr Phys Act, Hlth & Leisure, Porto, Portugal.
   [Baptista, Liliana C.] Univ Alabama Birmingham, Ctr Exercise Med, Birmingham, AL USA.
   [Baptista, Liliana C.] Univ Alabama Birmingham, Microbiome & Aging Lab, Targeted Exercise, Birmingham, AL USA.
   [Da Silva, Marco A. R.] Univ Coimbra, Fac Sport Sci & Phys Educ, Coimbra, Portugal.
   [Da Silva, Marco A. R.] Univ Amazonia, Dept Phys Educ, Belem, Brazil.
   [Fukushima, Andre R.; Hirota, Vinicius B.] Ctr Univ Amer, FAM, Sao Paulo, Brazil.
   [Fukushima, Andre R.] Fac Ciencias Saude, IGESP, FASIG, Sao Paulo, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade do Porto;
   University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham;
   Universidade de Coimbra; Universidade da Amazonia (UNAMA)
RP de Franca, E (corresponding author), Sao Judas Univ, Human Movement Lab, Sao Paulo, Brazil.; de Franca, E (corresponding author), Univ Fed Sao Paulo, Dept Biociencias, Sao Paulo, Brazil.
EM elias.franca@unifesp.br
RI Thomatieli-Santos, Ronaldo/C-8209-2012; de França, Elias/J-9867-2014; da
   Silva, Marco/AGM-6135-2022; Caperuto, Erico/I-3605-2014; Baptista,
   Liliana/AFM-0544-2022; barroso hirota, vinicius/D-1291-2014; Fukushima,
   Andre/A-7610-2017
OI barroso hirota, vinicius/0000-0002-0166-3338; Baptista,
   Liliana/0000-0002-3534-1839; Fukushima, Andre/0000-0001-6026-3054;
   Martins, Raul A./0000-0003-1194-4560
FU FAPESP-Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
   [2021/03601-01]; CAPES-Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior
FX EF is thankful to FAPESP-Fundacao de Amparo a Pesquisa do Estado de Sao
   Paulo (grant no. 2021/03601-01) and CAPES-Coordenacao de Aperfeicoamento
   de Pessoal de Nivel Superior to providing the Ph.D. and postdoctoral
   scholarships, respectively, which made possible to conduct such study
   and many other experiments.
CR Abbas A.K., 2019, INNATE IMMUNITY CELL, VNinth
   Abbas A.K., 2019, IMMUNOLOGIC TOLERANC, V9
   Adams V, 2005, CIRCULATION, V111, P555, DOI 10.1161/01.CIR.0000154560.88933.7E
   Agarwala Sonal, 2020, Iranian Society of Dermatology, V23, P155, DOI 10.22034/ijd.2020.120835
   Aguiar SS, 2021, EXP GERONTOL, V146, DOI 10.1016/j.exger.2020.111212
   Yousefabadi HA, 2021, BIOL RES NURS, V23, P280, DOI 10.1177/1099800420958068
   Alkhateeb A, 2003, PIGM CELL RES, V16, P208, DOI 10.1034/j.1600-0749.2003.00032.x
   Asea A, 2007, J BIOSCIENCES, V32, P579, DOI 10.1007/s12038-007-0057-5
   Atas H, 2017, BALK MED J, V34, P219, DOI 10.4274/balkanmedj.2016.1005
   Azzazi Y, 2021, PIGM CELL MELANOMA R, V34, P598, DOI 10.1111/pcmr.12941
   Barygina V, 2015, J DERMATOL SCI, V79, P163, DOI 10.1016/j.jdermsci.2015.05.003
   Bengal E, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21186480
   Bergqvist C, 2020, DERMATOLOGY, V236, P571, DOI 10.1159/000506103
   Bertolotti A, 2014, PIGM CELL MELANOMA R, V27, P398, DOI 10.1111/pcmr.12219
   Bhardwaj S, 2020, INT J DERMATOL, V59, P474, DOI 10.1111/ijd.14766
   Bishop DJ, 2014, BBA-GEN SUBJECTS, V1840, P1266, DOI 10.1016/j.bbagen.2013.10.012
   Bonomini F, 2015, AGING DIS, V6, P109, DOI 10.14336/AD.2014.0305
   Bonotis K, 2016, J DTSCH DERMATOL GES, V14, P45, DOI 10.1111/ddg.12729
   D'Arino A, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22168820
   Das S, 2015, CELL METAB, V21, P868, DOI 10.1016/j.cmet.2015.05.006
   de Sousa CV, 2017, SPORTS MED, V47, P277, DOI 10.1007/s40279-016-0566-1
   Dell'Anna ML, 2007, J INVEST DERMATOL, V127, P1226, DOI 10.1038/sj.jid.5700700
   Dell'Anna ML, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-13961-5
   Dell'Anna ML, 2010, J CELL PHYSIOL, V223, P187, DOI 10.1002/jcp.22027
   Dell'Anna ML, 2003, PIGM CELL RES, V16, P553, DOI 10.1034/j.1600-0749.2003.00087.x
   Demirbas A, 2021, ARCH DERMATOL RES, V313, P491, DOI 10.1007/s00403-020-02129-3
   Deng R, 2018, CLIN EPIGENETICS, V10, DOI 10.1186/s13148-018-0589-6
   Dimauro I, 2020, REDOX BIOL, V35, DOI 10.1016/j.redox.2020.101477
   Ding GZ, 2015, ARCH DERMATOL RES, V307, P281, DOI 10.1007/s00403-015-1544-4
   Dwivedi M, 2013, J INTERF CYTOK RES, V33, P646, DOI 10.1089/jir.2012.0171
   Edwardson CL, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034916
   Ellingsgaard H, 2019, CURR OPIN PHYSIOL, V10, P49, DOI 10.1016/j.cophys.2019.03.009
   Farrell SW, 2012, MED SCI SPORT EXER, V44, P2132, DOI 10.1249/MSS.0b013e31826524be
   Gafter U, 1997, J LAB CLIN MED, V130, P33, DOI 10.1016/S0022-2143(97)90056-1
   Gifford JR, 2016, J PHYSIOL-LONDON, V594, P1741, DOI 10.1113/JP271229
   Giri PS, 2020, PIGM CELL MELANOMA R, V33, P566, DOI 10.1111/pcmr.12862
   Gjevestad GO, 2015, CURR CARDIOVASC RISK, V9, DOI 10.1007/s12170-015-0463-4
   Glassman S J., 2014, Systems Biology of Free Radicals and Antioxidants, P3677
   Gounder SS, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0045697
   Han XL, 2007, BIOCHEMISTRY-US, V46, P6417, DOI 10.1021/bi7004015
   Hasan R, 2021, INT J DERMATOL, V60, pE390, DOI 10.1111/ijd.15330
   Hauff KD, 2009, CAN J PHYSIOL PHARM, V87, P813, DOI 10.1139/Y09-055
   Henríquez-Olguín C, 2019, ANTIOXID REDOX SIGN, V31, P1371, DOI 10.1089/ars.2018.7678
   Henríquez-Olguín C, 2016, FRONT PHYSIOL, V7, DOI 10.3389/fphys.2016.00282
   Hood DA, 2015, PROG MOL BIOL TRANSL, V135, P99, DOI 10.1016/bs.pmbts.2015.07.007
   Horsburgh S, 2015, PHYSIOL REP, V3, DOI 10.14814/phy2.12621
   Hou XY, 2022, J DERMATOL SCI, V105, P88, DOI 10.1016/j.jdermsci.2022.01.002
   JENKINS RR, 1993, MED SCI SPORT EXER, V25, P210
   Jian Z, 2014, J INVEST DERMATOL, V134, P2221, DOI 10.1038/jid.2014.152
   Jin CH, 2015, J EXERC REHABIL, V11, P198, DOI 10.12965/jer.150221
   Jin Y, 2007, NEW ENGL J MED, V356, P1216, DOI 10.1056/NEJMoa061592
   Karadag AS, 2011, ACTA DERM-VENEREOL, V91, P541, DOI 10.2340/00015555-1141
   Kocer B, 2009, EUR J NEUROL, V16, pE78, DOI 10.1111/j.1468-1331.2009.02563.x
   Krüger C, 2013, CURR PROBL DERMATOL, V44, P102, DOI 10.1159/000350010
   Krüger C, 2012, INT J DERMATOL, V51, P1206, DOI 10.1111/j.1365-4632.2011.05377.x
   Krüger K, 2014, EXERC IMMUNOL REV, V20, P117
   Laddha NC, 2014, EXP DERMATOL, V23, P352, DOI 10.1111/exd.12372
   Laddha NC, 2013, FREE RADICAL BIO MED, V65, P1110, DOI 10.1016/j.freeradbiomed.2013.08.189
   Le Poole I Caroline, 2017, J Investig Dermatol Symp Proc, V18, pS38, DOI 10.1016/j.jisp.2016.10.023
   Lee AY, 2004, BRIT J DERMATOL, V151, P995, DOI 10.1111/j.1365-2133.2004.06136.x
   Lee ECH, 2017, SCAND J MED SCI SPOR, V27, P66, DOI 10.1111/sms.12621
   Leeuwenburgh C, 2001, CURR MED CHEM, V8, P829, DOI 10.2174/0929867013372896
   Lionaki E, 2015, BBA-BIOENERGETICS, V1847, P1412, DOI 10.1016/j.bbabio.2015.04.010
   Lira FS, 2010, DIABETOL METAB SYNDR, V2, DOI 10.1186/1758-5996-2-7
   Little JP, 2011, J APPL PHYSIOL, V111, P1554, DOI 10.1152/japplphysiol.00921.2011
   Lotti T, 2015, EXPERT OPIN PHARMACO, V16, P2485, DOI 10.1517/14656566.2015.1087508
   Lotti T, 2014, CLIN DERMATOL, V32, P430, DOI 10.1016/j.clindermatol.2013.11.011
   Lu J, 2014, FREE RADICAL BIO MED, V66, P75, DOI 10.1016/j.freeradbiomed.2013.07.036
   Lu ZH, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.700055
   Ma SH, 2021, J AM ACAD DERMATOL, V85, P1465, DOI 10.1016/j.jaad.2020.12.029
   Maresca V, 1997, J INVEST DERMATOL, V109, P310, DOI 10.1111/1523-1747.ep12335801
   Margaritelis NV, 2018, ACTA PHYSIOL, V222, DOI 10.1111/apha.12898
   Martins C, 2022, J INVEST DERMATOL, V142, P1194, DOI 10.1016/j.jid.2021.09.015
   Minuzzi Luciele G, 2018, Exerc Immunol Rev, V24, P72
   Minuzzi LG, 2017, EUR J APPL PHYSIOL, V117, P1131, DOI 10.1007/s00421-017-3600-6
   Monteiro PA, 2017, CYTOKINE, V91, P104, DOI 10.1016/j.cyto.2016.12.007
   Mosenson J.A., 2013, THESIS LOYALA U CHIC
   Muthusamy VR, 2012, FREE RADICAL BIO MED, V52, P366, DOI 10.1016/j.freeradbiomed.2011.10.440
   Namazi N, 2021, DERMATOL THER, V34, DOI 10.1111/dth.14803
   Natarajan VT, 2014, P NATL ACAD SCI USA, V111, P2301, DOI 10.1073/pnas.1304988111
   Ni J, 2014, ENDOCR RES, V39, P180, DOI 10.3109/07435800.2013.879167
   Nilsson A, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-12934-8
   Ortona E, 2014, ANTIOXID REDOX SIGN, V21, P103, DOI 10.1089/ars.2013.5752
   Pannala VR, 2015, FREE RADICAL BIO MED, V78, P42, DOI 10.1016/j.freeradbiomed.2014.10.508
   Pareja-Galeano H, 2014, SPORTS MED, V44, P429, DOI 10.1007/s40279-013-0138-6
   Périard JD, 2016, AUTON NEUROSCI-BASIC, V196, P52, DOI 10.1016/j.autneu.2016.02.002
   Qi J, 2020, J DIABETES RES, V2020, DOI 10.1155/2020/2521590
   Radak Z., 2014, SYSTEMS BIOL FREE RA, P3855, DOI [10.1055/s-0029-1233464, DOI 10.1055/S-0029-1233464]
   Raleigh S.M., 2021, EPIGENETICS EXERCISE, P183
   Rashighi M, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3007811
   Rhind SG, 1996, EUR J APPL PHYSIOL O, V74, P348, DOI 10.1007/s004210050086
   Riding RL, 2019, J IMMUNOL, V203, P11, DOI 10.4049/jimmunol.1900027
   Sansbury BE, 2011, CHEM-BIOL INTERACT, V191, P288, DOI 10.1016/j.cbi.2010.12.002
   Schallreuter K.U., 2014, SYSTEMS BIOL FREE RA, P3697
   Schallreuter KU, 2012, FASEB J, V26, P2457, DOI 10.1096/fj.11-197137
   SCHALLREUTER KU, 1991, J INVEST DERMATOL, V97, P1081, DOI 10.1111/1523-1747.ep12492612
   SCHALLREUTER KU, 1991, BIOCHIM BIOPHYS ACTA, V1096, P277, DOI 10.1016/0925-4439(91)90063-F
   SCHALLREUTER KU, 1991, ARCH DERMATOL RES, V283, P449, DOI 10.1007/BF00371781
   SchallreuterWood KU, 1996, ARCH DERMATOL RES, V288, P11, DOI 10.1007/BF02505036
   Schlame M, 2017, BBA-MOL CELL BIOL L, V1862, P3, DOI 10.1016/j.bbalip.2016.08.010
   Shajil EM, 2006, PIGM CELL RES, V19, P179, DOI 10.1111/j.1600-0749.2006.00299.x
   Sharma LK, 2009, CURR MED CHEM, V16, P1266, DOI 10.2174/092986709787846578
   Sharma YK, 2017, DIABETES METAB SYND, V11, pS77, DOI 10.1016/j.dsx.2016.12.009
   Shaw DM, 2018, CYTOKINE, V104, P136, DOI 10.1016/j.cyto.2017.10.001
   Shi Q, 2016, CELL DEATH DIFFER, V23, P496, DOI 10.1038/cdd.2015.117
   Shi YL, 2013, PIGM CELL MELANOMA R, V26, P418, DOI 10.1111/pcmr.12086
   Shiu M., 2016, Modulation Of T Cell Distribution And Function By High-Intensity Interval Training
   Skurkovich B, 2006, E SCHERING RES FDN W, V56, P1
   Song GG, 2013, MOL BIOL REP, V40, P2985, DOI 10.1007/s11033-012-2370-9
   Stramucci L, 2018, CANCERS, V10, DOI 10.3390/cancers10050131
   Tanacan E, 2020, AN BRAS DERMATOL, V95, P165, DOI 10.1016/j.abd.2019.07.006
   Tarpey MD, 2017, MOL METAB, V6, P1597, DOI 10.1016/j.molmet.2017.10.006
   Teulings HE, 2013, BRIT J DERMATOL, V168, P162, DOI 10.1111/bjd.12111
   Tsai MF, 2014, J GEN PHYSIOL, V143, P67, DOI 10.1085/jgp.201311096
   Turner JE, 2016, MED SCI SPORT EXER, V48, P1285, DOI 10.1249/MSS.0000000000000914
   Vainshtein A, 2015, AM J PHYSIOL-CELL PH, V308, pC710, DOI 10.1152/ajpcell.00380.2014
   Vargas-Mendoza N, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8060196
   Venditti P, 1999, ARCH BIOCHEM BIOPHYS, V372, P315, DOI 10.1006/abbi.1999.1494
   Verma D, 2021, CUREUS J MED SCIENCE, V13, DOI 10.7759/cureus.14029
   Wang Y, 2015, J DERMATOL, V42, P193, DOI 10.1111/1346-8138.12725
   Xie H, 2016, J DERMATOL SCI, V81, P3, DOI 10.1016/j.jdermsci.2015.09.003
   You S, 2013, CLIN EXP IMMUNOL, V174, P38, DOI 10.1111/cei.12146
   Zhang YJ, 2014, J INVEST DERMATOL, V134, P183, DOI 10.1038/jid.2013.268
   Zhang ZB, 2021, J CLIN LAB ANAL, V35, DOI 10.1002/jcla.23648
   Zhao M, 2010, BRIT J DERMATOL, V163, P736, DOI 10.1111/j.1365-2133.2010.09919.x
   Zhou L, 2019, VITILIGO, P253
NR 126
TC 3
Z9 3
U1 1
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD MAR 10
PY 2022
VL 13
AR 843784
DI 10.3389/fphys.2022.843784
PG 18
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 0G9FH
UT WOS:000778343200001
PM 35360245
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Fang, YY
   Huang, CY
   Hsu, MC
AF Fang, Yun-Ya
   Huang, Chien-Yuan
   Hsu, Mei-Chi
TI Effectiveness of a physical activity program on weight, physical
   fitness, occupational stress, job satisfaction and quality of life of
   overweight employees in high-tech industries: a randomized controlled
   study
SO INTERNATIONAL JOURNAL OF OCCUPATIONAL SAFETY AND ERGONOMICS
LA English
DT Article
DE physical activity; overweight; occupational stress; job satisfaction;
   quality of life; nursing practice
ID CARDIORESPIRATORY FITNESS; EXERCISE INTERVENTION; CARDIOVASCULAR RISK;
   METABOLIC SYNDROME; HEALTH; DISEASE; HEART; WORK
AB Introduction. This study aimed to examine the effectiveness of a physical activity (PA) program on weight control, physical fitness, occupational stress, job satisfaction and quality of life of overweight and sedentary employees in high-tech industries. Methods. Participants in the intervention group (n = 37) were instructed to carry out a PA program at moderate intensity for 60 min/session, 3 sessions/week for 12 weeks. Those in the control group (n = 38) received no PA program and were asked to continue their routine lifestyle. Evaluations were performed at baseline and at the end of the intervention. Results of structured questionnaires and blood biochemistry tests and evaluations of physical fitness were analyzed. Results. The PA program effectively reduced the number of risk factors for metabolic syndrome and body fat percentage, and improved physical fitness such as flexibility, muscular strength and endurance and cardiorespiratory endurance. The intervention also significantly decreased levels of serum triglyceride, total cholesterol and low-density lipoprotein cholesterol. Significant positive effects on work control, interpersonal relationships at work, global job satisfaction and quality of life were also demonstrated. Conclusion. This study showed that a PA program can be helpful in improving physical, physiological and psychological outcomes for overweight and sedentary employees in high-tech industries.
C1 [Fang, Yun-Ya; Huang, Chien-Yuan] Chi Mei Med Ctr, Tainan Sci Pk Clin, Tainan, Taiwan.
   [Hsu, Mei-Chi] I Shou Univ, Dept Nursing, Kaohsiung, Taiwan.
C3 Chi Mei Hospital; I Shou University
RP Hsu, MC (corresponding author), I Shou Univ, Dept Nursing, Kaohsiung, Taiwan.
EM hsu88@isu.edu.tw
OI Yunya, Fang/0000-0003-1417-8347
CR Atlantis E, 2006, HEALTH PROMOT INT, V21, P191, DOI 10.1093/heapro/dal012
   Bogdanis GC, 2012, FRONT PHYSIOL, V3, DOI 10.3389/fphys.2012.00142
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Dieli-Conwright CM, 2015, CANCER EPIDEM BIOMAR, V24, P763, DOI 10.1158/1055-9965.EPI-15-0111
   Franklin BA, 2014, BEST PRACT RES CL EN, V28, P405, DOI 10.1016/j.beem.2014.01.005
   Harper A, 1998, PSYCHOL MED, V28, P551, DOI 10.1017/S0033291798006667
   [Health Promotion Administration Ministry of Health and Welfare, 2012, 38 PERC EMPL WORKPL
   Healy GN, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0119140
   Holtermann A, 2009, SCAND J WORK ENV HEA, V35, P466, DOI 10.5271/sjweh.1357
   [Institute of Labor Occupational Safety and Health (ILOSH) Minister of Labor Taiwan., 2014, MAN OCC STRESS ASS W
   Lira FS, 2012, J NUTR METAB, V2012, DOI 10.1155/2012/809576
   Marsden DL, 2013, NEUROREHAB NEURAL RE, V27, P775, DOI 10.1177/1545968313496329
   Meigs JB, 2003, DIABETES, V52, P2160, DOI 10.2337/diabetes.52.8.2160
   Moreira-Silva I, 2014, INT J OCCUP SAF ERGO, V20, P55, DOI 10.1080/10803548.2014.11077028
   Myers J, 2015, PROG CARDIOVASC DIS, V57, P306, DOI 10.1016/j.pcad.2014.09.011
   Naito M, 2008, ATHEROSCLEROSIS, V197, P784, DOI 10.1016/j.atherosclerosis.2007.07.026
   Napoli N, 2014, AM J CLIN NUTR, V100, P189, DOI 10.3945/ajcn.113.082883
   Naumann F, 2012, PSYCHO-ONCOLOGY, V21, P1136, DOI 10.1002/pon.2015
   Occupational Safety and Health Administration Ministry of Labor, OV PREV STAT OCC SAF
   Ohta M, 2015, INT J OCCUP SAF ERGO, V21, P141, DOI 10.1080/10803548.2015.1029293
   PATE RR, 1995, JAMA-J AM MED ASSOC, V273, P402, DOI 10.1001/jama.273.5.402
   Perri MG, 1997, J CONSULT CLIN PSYCH, V65, P278, DOI 10.1037/0022-006X.65.2.278
   Quintiliani L, 2007, WHO WORLD EC FOR WEF
   Shaibi GQ, 2015, EXERC SPORT SCI REV, V43, P41, DOI 10.1249/JES.0000000000000034
   Tetrick LE, 2015, ANNU REV ORGAN PSYCH, V2, P583, DOI 10.1146/annurev-orgpsych-032414-111341
   The WHOQOL Taiwan Group, 2000, US MAN WHOQOL BREF T
   Weiss D.J., 1967, Manual for the Minnesota Satisfaction Questionnaire, V22, DOI DOI 10.1037/T05540-000W
   Wood C, 2013, INT J ENVIRON HEAL R, V23, P311, DOI 10.1080/09603123.2012.733935
NR 28
TC 49
Z9 52
U1 2
U2 88
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1080-3548
EI 2376-9130
J9 INT J OCCUP SAF ERGO
JI Int. J. Occup. Saf. Ergon.
PD OCT 2
PY 2019
VL 25
IS 4
BP 621
EP 629
DI 10.1080/10803548.2018.1438839
PG 9
WC Ergonomics; Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Engineering; Public, Environmental & Occupational Health
GA IM4JS
UT WOS:000477961300015
PM 29465293
DA 2025-06-11
ER

PT J
AU Sladowska-Kozlowska, J
   Litwin, M
   Niemirska, A
   Pludowski, P
   Wierzbicka, A
   Skorupa, E
   Wawer, ZT
   Janas, R
AF Sladowska-Kozlowska, Joanna
   Litwin, Mieczyslaw
   Niemirska, Anna
   Pludowski, Pawel
   Wierzbicka, Aldona
   Skorupa, Ewa
   Wawer, Zbigniew T.
   Janas, Roman
TI Oxidative stress in hypertensive children before and after 1 year of
   antihypertensive therapy
SO PEDIATRIC NEPHROLOGY
LA English
DT Article; Proceedings Paper
CT Meeting of the European-Society-of-Hypertension
CY 2011
CL Milan, ITALY
SP European Soc Hypertens
DE Primary hypertension; Oxidative stress; Metabolic syndrome; Insulin
   resistance; Target organ damage; Antihypertensive therapy; Children
ID INTIMA-MEDIA THICKNESS; NITRIC-OXIDE SYNTHASE; AMBULATORY
   BLOOD-PRESSURE; OXYGEN SPECIES FORMATION; LEFT-VENTRICULAR MASS;
   INSULIN-RESISTANCE; RECOMMENDATIONS; ADOLESCENTS; OVERWEIGHT; INHIBITORS
AB The relation between primary hypertension (PH), target organ damage (TOD) and oxidative stress (SOX) is not known.
   We assessed SOX in 86 children with PH before and after 12 months of standard non-pharmacological and pharmacological therapy based on renin-angiotensin system blockade.
   Patients with left ventricular hypertrophy (LVH) and with carotid intima-media thickness (cIMT) > 2SDS had higher thiobarbituric acid reactive substances (TBARS) concentrations in comparison to patients without LVH or with normal cIMT. Patients with metabolic syndrome (MS) had lower activity of gluthatione peroxidase, higher asymmetric dimethyloarginine (ADMA) and oxidized LDL cholesterol (oxyLDL) in comparison to patients without MS. TBARS correlated with left ventricular concentric hypertrophy, cIMT, albuminuria and SBP/24 h. ADMA and oxyLDL correlated with CRP and TG/HDL ratio. After 1 year of antihypertensive treatment blood pressure, TOD and prevalence of MS decreased. TBARS decreased and glutathione concentrations increased. The decrease of TBARS concentration correlated with the decrease of body mass index (BMI). Decrease of oxyLDL and ADMA correlated with increased insulin sensitivity, however markers of SOX did not correlate with BP decrease.
   SOX in children with PH correlates with TOD, metabolic abnormalities, changes in fat amount and improvement of insulin sensitivity, but not with BP decrease.
C1 [Litwin, Mieczyslaw] Childrens Mem Hlth Inst, Dept Res, Warsaw, Poland.
   [Sladowska-Kozlowska, Joanna; Litwin, Mieczyslaw; Niemirska, Anna] Childrens Mem Hlth Inst, Dept Nephrol & Arterial Hypertens, Warsaw, Poland.
   [Pludowski, Pawel; Wierzbicka, Aldona; Skorupa, Ewa; Wawer, Zbigniew T.] Childrens Mem Hlth Inst, Dept Biochem & Expt Med, Warsaw, Poland.
   [Janas, Roman] Childrens Mem Hlth Inst, Dept Radioimmunol, Warsaw, Poland.
C3 Children's Memorial Health Institute; Children's Memorial Health
   Institute; Children's Memorial Health Institute; Children's Memorial
   Health Institute
RP Litwin, M (corresponding author), Childrens Mem Hlth Inst, Dept Res, Warsaw, Poland.
EM m.litwin@czd.pl
RI Pludowski, Pawel/P-2154-2018; Litwin, Mieczyslaw/L-4648-2017; Niemirska,
   Anna/W-2780-2018
OI Pludowski, Pawel/0000-0001-8475-7112; Janas, Roman/0000-0003-2853-9676;
   Litwin, Mieczyslaw/0000-0002-5241-2483; Niemirska,
   Anna/0000-0003-4546-5541; Wawer, Zbigniew/0000-0002-8866-4578;
   Wierzbicka-Rucinska, Aldona/0000-0002-9578-8894
CR Baykal Y, 2003, J HYPERTENS, V21, P1207, DOI 10.1097/00004872-200306000-00022
   Blankenberg S, 2003, NEW ENGL J MED, V349, P1605, DOI 10.1056/NEJMoa030535
   Brown LA, 2009, OBESITY, V17, P460, DOI 10.1038/oby.2008.590
   Cole TJ, 2000, BMJ-BRIT MED J, V320, P1240, DOI 10.1136/bmj.320.7244.1240
   DANIELS SR, 1988, J AM COLL CARDIOL, V12, P703, DOI 10.1016/S0735-1097(88)80060-3
   DESIMONE G, 1992, J AM COLL CARDIOL, V20, P1251, DOI 10.1016/0735-1097(92)90385-Z
   DEVEREUX RB, 1986, AM J CARDIOL, V57, P450, DOI 10.1016/0002-9149(86)90771-X
   Evans JL, 2003, DIABETES, V52, P1, DOI 10.2337/diabetes.52.1.1
   Goonasekera CDA, 1997, J HYPERTENS, V15, P901, DOI 10.1097/00004872-199715080-00015
   Järvisalo MJ, 2002, DIABETES, V51, P493, DOI 10.2337/diabetes.51.2.493
   Jourdan C, 2005, J HYPERTENS, V23, P1707, DOI 10.1097/01.hjh.0000178834.26353.d5
   Kapur S, 1997, DIABETES, V46, P1691, DOI 10.2337/diabetes.46.11.1691
   Kelly Aaron S, 2006, J Cardiometab Syndr, V1, P248, DOI 10.1111/j.1559-4564.2006.05758.x
   Khoury PR, 2009, J AM SOC ECHOCARDIOG, V22, P709, DOI 10.1016/j.echo.2009.03.003
   Kristal B, 1998, AM J HYPERTENS, V11, P921, DOI 10.1016/S0895-7061(98)00099-5
   Litwin M, 2007, AM J HYPERTENS, V20, P875, DOI 10.1016/j.amjhyper.2007.03.005
   Litwin M, 2010, PEDIATR NEPHROL, V25, P2489, DOI 10.1007/s00467-010-1626-7
   Lurbe E, 2009, J HYPERTENS, V27, P1719, DOI 10.1097/HJH.0b013e32832f4f6b
   Melikoglu MA, 2008, J SPORT MED PHYS FIT, V48, P388
   Moreno MU, 2006, J HYPERTENS, V24, P1299, DOI 10.1097/01.hjh.0000234110.54110.56
   National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents, 2004, EVALUATION TREATMENT, V114, P555
   Ono H, 2008, HYPERTENS RES, V31, P271, DOI 10.1291/hypres.31.271
   Palm F, 2007, AM J PHYSIOL-HEART C, V293, pH3227, DOI 10.1152/ajpheart.00998.2007
   Park K, 2009, DIABETES CARE, V32, P1302, DOI 10.2337/dc09-0259
   Pedro-Botet J, 2000, J HUM HYPERTENS, V14, P343, DOI 10.1038/sj.jhh.1001034
   Perticone F, 2010, INT J CARDIOL, V142, P236, DOI 10.1016/j.ijcard.2008.12.131
   Redón J, 2003, HYPERTENSION, V41, P1096, DOI 10.1161/01.HYP.0000068370.21009.38
   Rudich A, 1998, DIABETES, V47, P1562, DOI 10.2337/diabetes.47.10.1562
   Russo C, 1998, J HYPERTENS, V16, P1267, DOI 10.1097/00004872-199816090-00007
   Siemianowicz K, 2003, SCAND J CLIN LAB INV, V63, P151, DOI 10.1080/00365510310002013
   Sinaiko AR, 2005, CIRCULATION, V111, P1985, DOI 10.1161/01.CIR.0000161837.23846.57
   Sladowska-Kozlowska J, 2011, PEDIATR NEPHROL, V26, P2201, DOI 10.1007/s00467-011-1916-8
   Stühlinger MC, 2002, JAMA-J AM MED ASSOC, V287, P1420, DOI 10.1001/jama.287.11.1420
   Sydow K, 2005, VASC MED, V10, pS35, DOI 10.1191/1358863x05vm604oa
   Touyz RM, 2004, HYPERTENSION, V44, P248, DOI 10.1161/01.HYP.0000138070.47616.9d
   Túri S, 2003, J HYPERTENS, V21, P145, DOI 10.1097/00004872-200301000-00024
   Urbina E, 2008, HYPERTENSION, V52, P433, DOI 10.1161/HYPERTENSIONAHA.108.190329
   Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
   Vaziri ND, 2000, HYPERTENSION, V36, P142, DOI 10.1161/01.HYP.36.1.142
   Watanabe T, 2006, J HUM HYPERTENS, V20, P336, DOI 10.1038/sj.jhh.1001990
   Whyte JJ, 2010, ACTA PHYSIOL, V199, P441, DOI 10.1111/j.1748-1716.2010.02127.x
   Wühl E, 2002, J HYPERTENS, V20, P1995, DOI 10.1097/00004872-200210000-00019
   Yagi S, 2004, HYPERTENS RES, V27, P129, DOI 10.1291/hypres.27.129
   Yasunari K, 2004, J AM COLL CARDIOL, V43, P2116, DOI 10.1016/j.jacc.2003.12.051
NR 44
TC 26
Z9 26
U1 0
U2 14
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0931-041X
EI 1432-198X
J9 PEDIATR NEPHROL
JI Pediatr. Nephrol.
PD OCT
PY 2012
VL 27
IS 10
BP 1943
EP 1951
DI 10.1007/s00467-012-2193-x
PG 9
WC Pediatrics; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Pediatrics; Urology & Nephrology
GA 992EL
UT WOS:000307758300016
PM 22660895
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Pedrosa, MA
   Labandeira, CM
   Lago-Baameiro, N
   Valenzuela, R
   Pardo, M
   Labandeira-Garcia, JL
   Rodriguez-Perez, AI
AF Pedrosa, Maria A.
   Labandeira, Carmen M.
   Lago-Baameiro, Nerea
   Valenzuela, Rita
   Pardo, Maria
   Labandeira-Garcia, Jose Luis
   Rodriguez-Perez, Ana I.
TI Extracellular Vesicles and Their Renin-Angiotensin Cargo as a Link
   between Metabolic Syndrome and Parkinson's Disease
SO ANTIOXIDANTS
LA English
DT Article
DE adipocytes; angiotensin receptor blockers; exosomes; NADPH-oxidase;
   neurodegeneration; neuroinflammation; obesity; oxidative stress
ID EXOSOME-MEDIATED TRANSFER; ADIPOSE-TISSUE; NADPH-OXIDASE; SYSTEM;
   OBESITY; MECHANISM; INFLAMMATION; ADIPOCYTES; BIOLOGY; KINASE
AB Several studies showed an association between metabolic syndrome (MetS) and Parkinson's disease (PD). The linking mechanisms remain unclear. MetS promotes low-grade peripheral oxidative stress and inflammation and dysregulation of the adipose renin-angiotensin system (RAS). Interestingly, brain RAS dysregulation is involved in the progression of dopaminergic degeneration and PD. Circulating extracellular vesicles (EVs) from MetS fat tissue can cross the brain-blood barrier and may act as linking signals. We isolated and characterized EVs from MetS and control rats and analyzed their mRNA and protein cargo using RT-PCR and the ExoView R200 platform, respectively. Furthermore, cultures of the N27 dopaminergic cell line and the C6 astrocytic cell line were treated with EVs from MetS rats. EVs were highly increased in MetS rat serum, which was inhibited by treatment of the rats with the angiotensin type-1-receptor blocker candesartan. Furthermore, EVs from MetS rats showed increased pro-oxidative/pro-inflammatory and decreased anti-oxidative/anti-inflammatory RAS components, which were inhibited in candesartan-treated MetS rats. In cultures, EVs from MetS rats increased N27 cell death and modulated C6 cell function, upregulating markers of neuroinflammation and oxidative stress, which were inhibited by the pre-treatment of cultures with candesartan. The results from rat models suggest EVs and their RAS cargo as a mechanism linking Mets and PD.
C1 [Pedrosa, Maria A.; Valenzuela, Rita; Labandeira-Garcia, Jose Luis; Rodriguez-Perez, Ana I.] Univ Santiago de Compostela, Res Ctr Mol Med & Chron Dis CIMUS, Cellular & Mol Neurobiol Parkinsons Dis, Inst Invest Sanitaria Santiago de Compostela IDIS, Santiago De Compostela 15782, Spain.
   [Pedrosa, Maria A.; Valenzuela, Rita; Labandeira-Garcia, Jose Luis; Rodriguez-Perez, Ana I.] Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid 28029, Spain.
   [Labandeira, Carmen M.] Univ Hosp Ourense, Neurol Serv, Orense 32005, Spain.
   [Lago-Baameiro, Nerea; Pardo, Maria] Complexo Hosp Univ Santiago de Compostela, Grp Obesid, Area Endocrinol, Inst Invest Sanitaria Santiago de Compostela IDIS, Santiago De Compostela 15706, Spain.
   [Pardo, Maria] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr, Madrid 28029, Spain.
C3 Universidade de Santiago de Compostela; CIBERNED; Complexo Hospitalario
   Universitario de Ourense, Verin e O Barco de Valdeorras; Complexo
   Hospitalario Universitario de Santiago de Compostela; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III
RP Labandeira-Garcia, JL; Rodriguez-Perez, AI (corresponding author), Univ Santiago de Compostela, Res Ctr Mol Med & Chron Dis CIMUS, Cellular & Mol Neurobiol Parkinsons Dis, Inst Invest Sanitaria Santiago de Compostela IDIS, Santiago De Compostela 15782, Spain.; Labandeira-Garcia, JL; Rodriguez-Perez, AI (corresponding author), Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid 28029, Spain.
EM mary.pedrosa@usc.es; carmen.maria.labandeira.guerra@sergas.es;
   nerealagobaameiro@gmail.com; rita.valenzuela@usc.es;
   maria.pardo.perez@sergas.es; joseluis.labandeira@usc.es;
   anai.rodriguez@usc.es
RI García, José/AAM-3097-2021; Pedrosa, Maria A/ABA-2393-2021; Perez,
   Ana/AAM-1198-2021; Pardo, Maria/C-5124-2012
OI Valenzuela Liminana, Rita/0000-0001-8181-2841; Lago Baameiro,
   Nerea/0000-0003-1257-4856; Novoa Perez, Maria Iria/0009-0002-6073-9520;
   Pardo, Maria/0000-0002-9967-1650; Labandeira-Garcia, Jose
   Luis/0000-0002-8243-9791; Rodriguez Perez, Ana
   Isabel/0000-0003-1354-8799; Gianzo Quintela,
   Cristina/0009-0001-0012-0964; Labandeira Guerra, Carmen
   M./0000-0002-6274-5871; Aldrey Garcia, Maria Pilar/0009-0004-2253-1432;
   Pedrosa/0000-0001-9553-8513
FU Spanish Ministry of Science and Innovation
FX We thank Pilar Aldrey, Iria Novoa, and Cristina Gianzo for their
   technical assistance.
CR Agouni A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027809
   Akbar N, 2019, DIABETOLOGIA, V62, P2179, DOI 10.1007/s00125-019-05014-5
   Arab T, 2021, J EXTRACELL VESICLES, V10, DOI 10.1002/jev2.12079
   Banks WA, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21124407
   Bhat SA, 2018, MOL NEUROBIOL, V55, P5282, DOI 10.1007/s12035-017-0754-5
   Booth HDE, 2017, TRENDS NEUROSCI, V40, P358, DOI 10.1016/j.tins.2017.04.001
   Calabrese V, 2018, FREE RADICAL BIO MED, V115, P80, DOI 10.1016/j.freeradbiomed.2017.10.379
   Camino T, 2023, BIOMEDICINES, V11, DOI 10.3390/biomedicines11020422
   Camino T, 2022, TRANSL RES, V239, P85, DOI 10.1016/j.trsl.2021.01.006
   Cano A, 2023, INT J BIOL SCI, V19, P721, DOI 10.7150/ijbs.79063
   Chakrabarti S, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12040955
   Chaudhuri AD, 2020, GLIA, V68, P128, DOI 10.1002/glia.23708
   Chaudhuri AD, 2018, CELL DEATH DIS, V9, DOI 10.1038/s41419-018-0369-4
   Chiaradia E, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10071763
   Daaboul GG, 2016, SCI REP-UK, V6, DOI 10.1038/srep37246
   Dang SY, 2019, INT J BIOL SCI, V15, P351, DOI 10.7150/ijbs.28522
   de Kloet AD, 2010, PHYSIOL BEHAV, V100, P525, DOI 10.1016/j.physbeh.2010.03.018
   Dominguez-Meijide A, 2017, BRAIN BEHAV IMMUN, V62, P277, DOI 10.1016/j.bbi.2017.02.013
   Eguchi A, 2016, J MOL MED, V94, P1241, DOI 10.1007/s00109-016-1446-8
   Engeli S, 2003, INT J BIOCHEM CELL B, V35, P807, DOI 10.1016/S1357-2725(02)00311-4
   Ferrante SC, 2015, PEDIATR RES, V77, P447, DOI 10.1038/pr.2014.202
   Frigolet ME, 2013, J NUTR BIOCHEM, V24, P2003, DOI 10.1016/j.jnutbio.2013.07.002
   Griendling KK, 2000, CIRC RES, V86, P494, DOI 10.1161/01.RES.86.5.494
   Gupta S, 2007, AM J PHYSIOL-HEART C, V292, pH3052, DOI 10.1152/ajpheart.01355.2006
   Gupte M, 2008, AM J PHYSIOL-REG I, V295, pR781, DOI 10.1152/ajpregu.00183.2008
   Hara Y, 2011, SCI SIGNAL, V4, DOI 10.1126/scisignal.2001227
   Haron S, 2021, FRONT BIOSCI-LANDMRK, V26, P628, DOI 10.52586/4972
   Hassanzadeh K, 2019, J CELL PHYSIOL, V234, P23, DOI 10.1002/jcp.26865
   Hong H, 2006, AM J PHYSIOL-HEART C, V291, pH2210, DOI 10.1152/ajpheart.01270.2005
   Hurwitz SN, 2016, J EXTRACELL VESICLES, V5, DOI 10.3402/jev.v5.31295
   Jackson L, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19030876
   Jin Y, 2022, BIOL RES, V55, DOI 10.1186/s40659-022-00405-2
   Jo Y, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.837890
   Jones BH, 1997, AM J PHYSIOL-REG I, V273, pR236, DOI 10.1152/ajpregu.1997.273.1.R236
   Kalupahana NS, 2012, OBES REV, V13, P136, DOI 10.1111/j.1467-789X.2011.00942.x
   Kamath T, 2022, NAT NEUROSCI, V25, P588, DOI 10.1038/s41593-022-01061-1
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Khan NZ, 2021, BRAIN BEHAV IMMUN, V92, P165, DOI 10.1016/j.bbi.2020.12.007
   Kintscher U, 2007, CARDIOVASC DIABETOL, V6, DOI 10.1186/1475-2840-6-12
   Kusters CDJ, 2021, MOVEMENT DISORD, V36, P2264, DOI 10.1002/mds.28760
   Kwon HS, 2020, TRANSL NEURODEGENER, V9, DOI 10.1186/s40035-020-00221-2
   Labandeira CM, 2022, NPJ PARKINSONS DIS, V8, DOI 10.1038/s41531-022-00340-9
   Labandeira-Garcia JL, 2021, PROG NEUROBIOL, V199, DOI 10.1016/j.pneurobio.2020.101919
   Labandeira-García JL, 2014, FRONT NEUROANAT, V8, DOI 10.3389/fnana.2014.00067
   Lazar I, 2016, CANCER RES, V76, P4051, DOI 10.1158/0008-5472.CAN-16-0651
   Lee JE, 2015, PROTEIN J, V34, P220, DOI 10.1007/s10930-015-9616-z
   Li JJ, 2018, J NEUROINFLAMM, V15, DOI 10.1186/s12974-017-1038-8
   Lin HC, 2022, AM J MED, V135, P1001, DOI 10.1016/j.amjmed.2022.04.029
   Lopez-Lopez A, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12071454
   Lyu LM, 2015, J MOL CELL CARDIOL, V89, P268, DOI 10.1016/j.yjmcc.2015.10.022
   Maeda A, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/946492
   Martinez Fernando O, 2014, F1000Prime Rep, V6, P13, DOI 10.12703/P6-13
   Masenga SK, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24097898
   MILSTED A, 1990, P NATL ACAD SCI USA, V87, P5720, DOI 10.1073/pnas.87.15.5720
   Mitchell CS, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.682726
   Monserrat-Mesquida M, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9030236
   Morales-Prieto DM, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11040625
   Nam GE, 2018, PLOS MED, V15, DOI 10.1371/journal.pmed.1002640
   Novaes AD, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-42746-1
   Parga JA, 2018, FREE RADICAL BIO MED, V129, P394, DOI 10.1016/j.freeradbiomed.2018.10.409
   Pedrosa MA, 2023, BRAIN BEHAV IMMUN, V108, P255, DOI 10.1016/j.bbi.2022.12.009
   Peng ZY, 2018, PARKINSONISM RELAT D, V55, P68, DOI 10.1016/j.parkreldis.2018.05.013
   Pettersson US, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046057
   Pinheiro TD, 2017, J NUTR BIOCHEM, V48, P74, DOI 10.1016/j.jnutbio.2017.06.008
   Qi Y, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21155398
   Ramos-Zaldívar HM, 2022, FLUIDS BARRIERS CNS, V19, DOI 10.1186/s12987-022-00359-3
   Ravarotto V, 2015, J RENIN-ANGIO-ALDO S, V16, P1245, DOI 10.1177/1470320315594324
   Rocca WA, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2022.38663
   Rodriguez-Perez AI, 2018, NEUROTHERAPEUTICS, V15, P1063, DOI 10.1007/s13311-018-0646-z
   Rodriguez-Perez AI, 2015, GLIA, V63, P466, DOI 10.1002/glia.22765
   Saravi B, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10030650
   Savina A, 2002, J CELL SCI, V115, P2505
   Silverman JM, 2011, CELL MICROBIOL, V13, P1, DOI 10.1111/j.1462-5822.2010.01537.x
   STORNETTA RL, 1988, SCIENCE, V242, P1444, DOI 10.1126/science.3201232
   Théry C, 2018, J EXTRACELL VESICLES, V7, DOI 10.1080/20013078.2018.1535750
   Tong Y, 2018, HYPERTENSION, V72, P881, DOI 10.1161/HYPERTENSIONAHA.118.11375
   Valadi H, 2007, NAT CELL BIOL, V9, P654, DOI 10.1038/ncb1596
   Valenzuela R, 2021, REDOX BIOL, V46, DOI 10.1016/j.redox.2021.102078
   Valenzuela R, 2010, J NEUROPATH EXP NEUR, V69, P1130, DOI 10.1097/NEN.0b013e3181fa0308
   Vargas-Castillo A, 2020, METABOLISM, V103, DOI 10.1016/j.metabol.2019.154048
   Wang J, 2022, CELL METAB, V34, P1264, DOI 10.1016/j.cmet.2022.08.004
   Xia XH, 2022, TRANSL NEURODEGENER, V11, DOI 10.1186/s40035-022-00330-0
   Yang YY, 2018, J NEUROINFLAMM, V15, DOI 10.1186/s12974-018-1204-7
   You Y, 2020, J EXTRACELL VESICLES, V9, DOI 10.1080/20013078.2019.1706801
   Zhao S, 2021, NEUROSCI BIOBEHAV R, V125, P148, DOI 10.1016/j.neubiorev.2021.02.027
NR 85
TC 7
Z9 8
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD DEC
PY 2023
VL 12
IS 12
AR 2045
DI 10.3390/antiox12122045
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA DF4J7
UT WOS:001130599000001
PM 38136165
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dallio, M
   Diano, N
   Masarone, M
   Gravina, AG
   Patanè, V
   Romeo, M
   Di Sarno, R
   Errico, S
   Nicolucci, C
   Abenavoli, L
   Scarpellini, E
   Boccuto, L
   Persico, M
   Loguercio, C
   Federico, A
AF Dallio, Marcello
   Diano, Nadia
   Masarone, Mario
   Gravina, Antonietta Gerarda
   Patane, Vittorio
   Romeo, Mario
   Di Sarno, Rosa
   Errico, Sonia
   Nicolucci, Carla
   Abenavoli, Ludovico
   Scarpellini, Emidio
   Boccuto, Luigi
   Persico, Marcello
   Loguercio, Carmelina
   Federico, Alessandro
TI Chemical Effect of Bisphenol A on Non-Alcoholic Fatty Liver Disease
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Review
DE bisphenol A; endocrine-disrupting compounds; oxidative stress;
   non-alcoholic fatty liver disease; hepatocellular carcinoma
ID PERINATAL EXPOSURE; GENE-EXPRESSION; LIPID-ACCUMULATION;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; METABOLISM; ACTIVATION; HEALTH;
   BPA
AB Non-alcoholic fatty liver disease (NAFLD) is considered a predominant chronic liver disease worldwide and a component of metabolic syndrome. Due to its relationship with multiple organs, it is extremely complex to precisely define its pathogenesis as well as to set appropriate therapeutic and preventive strategies. Endocrine disruptors (EDCs) in general, and bisphenol A (BPA) in particular, are a heterogeneous group of substances, largely distributed in daily use items, able to interfere with the normal signaling of several hormones that seem to be related to type 2 diabetes mellitus (T2DM), obesity, and other metabolic disorders. It is reasonable to hypothesize a BPA involvement in the pathogenesis and evolution of NAFLD. However, its mechanisms of action as well as its burden in the vicious circle that connects obesity, T2DM, metabolic syndrome, and NAFLD still remain to be completely defined. In this review we analyzed the scientific evidence on this promising research area, in order to provide an overview of the harmful effects linked to the exposure to EDCs as well as to frame the role that BPA would have in all phases of NAFLD evolution.
C1 [Dallio, Marcello; Gravina, Antonietta Gerarda; Patane, Vittorio; Romeo, Mario; Di Sarno, Rosa; Loguercio, Carmelina; Federico, Alessandro] Univ Campania Luigi Vanvitelli, Dept Precis Med, Via Pansini 5, I-80131 Naples, Italy.
   [Diano, Nadia; Errico, Sonia; Nicolucci, Carla] Univ Campania Luigi Vanvitelli, Dept Expt Med, Via Pansini 5, I-80131 Naples, Italy.
   [Masarone, Mario; Persico, Marcello] Univ Salerno, Dept Med & Surg, Via Salvador Allende, I-84081 Salerno, Italy.
   [Abenavoli, Ludovico] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Viale Europa Germaneto, I-88110 Catanzaro, Italy.
   [Scarpellini, Emidio] Univ Hosp Gasthuisberg, Dept Internal Med, Div Gastroenterol, TARGID, B-3000 Leuven, Belgium.
   [Boccuto, Luigi] Greenwood Genet Ctr, 113 Gregor Mendel Circle, Greenwood, SC 29646 USA.
C3 Universita della Campania Vanvitelli; Universita della Campania
   Vanvitelli; University of Salerno; Magna Graecia University of
   Catanzaro; KU Leuven; University Hospital Leuven; Greenwood Genetic
   Center
RP Dallio, M (corresponding author), Univ Campania Luigi Vanvitelli, Dept Precis Med, Via Pansini 5, I-80131 Naples, Italy.
EM marcello.dallio@gmail.com
RI Abenavoli, Ludovico/J-4394-2019; Gravina, Antonietta
   Gerarda/AAC-1528-2019; Scarpellini, Emidio/AAT-2052-2020; Diano,
   Nadia/AAS-7358-2021; Patane, Vittorio/NEU-0770-2025; Dallio,
   Marcello/ABG-7693-2020; persico, marcello/AAB-3562-2019; Federico,
   Alessandro/AAB-3893-2019; Masarone, Mario/H-8633-2017; ,
   Vittorio/JNR-9856-2023
OI Scarpellini, Emidio/0000-0002-2101-1118; Persico,
   Marcello/0000-0002-1399-6498; MONTEBIANCO ABENAVOLI,
   Ludovico/0000-0002-5922-1524; Romeo, Mario/0000-0002-2970-9019;
   Masarone, Mario/0000-0003-0550-8201; Diano, Nadia/0000-0003-4433-2667;
   DALLIO, MARCELLO/0000-0003-4153-815X; Federico,
   Alessandro/0000-0002-0885-0793; , Vittorio/0000-0003-0767-3884
CR Abdeen A, 2019, ENVIRON SCI POLLUT R, V26, P25167, DOI 10.1007/s11356-019-05783-x
   Acaroz U, 2019, TOXICOL RES-UK, V8, P262, DOI [10.1039/c8tx00312b, 10.1039/C8TX00312B]
   Adams LA, 2005, CAN MED ASSOC J, V172, P899, DOI 10.1503/cmaj.045232
   Adams LA, 2005, J HEPATOL, V42, P132, DOI 10.1016/j.jhep.2004.09.012
   Alisi A, 2017, MEDIAT INFLAMM, V2017, P1
   Arrese M, 2016, DIGEST DIS SCI, V61, P1294, DOI 10.1007/s10620-016-4049-x
   Begriche K, 2006, MITOCHONDRION, V6, P1, DOI 10.1016/j.mito.2005.10.004
   Braniste V, 2010, P NATL ACAD SCI USA, V107, P448, DOI 10.1073/pnas.0907697107
   Braun JM, 2017, NAT REV ENDOCRINOL, V13, P161, DOI 10.1038/nrendo.2016.186
   Bugianesi E, 2005, DIABETOLOGIA, V48, P634, DOI 10.1007/s00125-005-1682-x
   Chevalier N, 2015, REV ENDOCR METAB DIS, V16, P299, DOI 10.1007/s11154-016-9333-8
   Cho S, 2018, ENVIRON TOXICOL PHAR, V58, P1, DOI 10.1016/j.etap.2017.12.008
   Dallio M, 2018, ALIMENT PHARM THER, V47, P826, DOI 10.1111/apt.14499
   Diamanti-Kandarakis E, 2009, ENDOCR REV, V30, P293, DOI 10.1210/er.2009-0002
   Dong S, 2011, ENVIRON POLLUT, V159, P212, DOI 10.1016/j.envpol.2010.09.004
   Dunder L, 2018, ENVIRON RES, V166, P117, DOI 10.1016/j.envres.2018.05.023
   Ekstedt M, 2006, HEPATOLOGY, V44, P865, DOI 10.1002/hep.21327
   Federico A, 2016, EUR REV MED PHARMACO, V20, P4731
   Federico A, 2017, MINERVA GASTROENTERO, V63, P385, DOI 10.23736/S1121-421X.17.02375-3
   Federico A, 2017, IN VIVO, V31, P609, DOI 10.21873/invivo.11101
   Federico A, 2016, TRANSL RES, V167, P116, DOI 10.1016/j.trsl.2015.08.002
   Fic A, 2013, ARH HIG RADA TOKSIKO, V64, P189, DOI 10.2478/10004-1254-64-2013-2319
   Gassman NR, 2017, ENVIRON MOL MUTAGEN, V58, P60, DOI 10.1002/em.22072
   Gore AC, 2015, ENDOCR REV, V36, pE1, DOI 10.1210/er.2015-1010
   Goyal D, 2019, J ENDOCRINOL, V242, pT105, DOI 10.1530/JOE-19-0009
   Hassani FV, 2018, FOOD CHEM TOXICOL, V112, P26, DOI 10.1016/j.fct.2017.12.021
   Heindel JJ, 2017, REPROD TOXICOL, V68, P3, DOI 10.1016/j.reprotox.2016.10.001
   Hercog K, 2019, SCI TOTAL ENVIRON, V687, P267, DOI 10.1016/j.scitotenv.2019.05.486
   Huc L, 2012, TOXICOL IN VITRO, V26, P709, DOI 10.1016/j.tiv.2012.03.017
   Hwang KA, 2013, TOXICOL APPL PHARM, V272, P637, DOI 10.1016/j.taap.2013.07.027
   Izzotti A, 2009, MUTAT RES-GEN TOX EN, V679, P28, DOI 10.1016/j.mrgentox.2009.07.011
   Kang HS, 2014, J PHYSIOL PHARMACOL, V65, P273
   Kim D, 2017, CLIN GASTROENTEROL H, V15, P474, DOI 10.1016/j.cgh.2016.08.028
   Kirkley AG, 2014, CURR DIABETES REP, V14, DOI 10.1007/s11892-014-0494-0
   Kolsek K, 2012, TOXICOL IN VITRO, V26, P102, DOI 10.1016/j.tiv.2011.11.003
   Labaronne E, 2017, J NUTR BIOCHEM, V45, P83, DOI 10.1016/j.jnutbio.2017.04.001
   Lama S, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-40105-8
   Le Magueresse-Battistoni Brigitte, 2017, World J Biol Chem, V8, P108, DOI 10.4331/wjbc.v8.i2.108
   Lin Y, 2017, BBA-MOL CELL BIOL L, V1862, P869, DOI 10.1016/j.bbalip.2017.05.001
   Lindenmeyer CC, 2018, CLIN LIVER DIS, V22, P11, DOI 10.1016/j.cld.2017.08.003
   Malaisé Y, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-15196-w
   Marmugi A., 2012, ANN ENDOCRINOL, V73, P420
   Martella A, 2016, ENDOCRINOLOGY, V157, P1751, DOI 10.1210/en.2015-1384
   Masarone M, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/9547613
   Mikolajewska K, 2015, INT J OCCUP MED ENV, V28, P209, DOI 10.13075/ijomeh.1896.00343
   Muñoz-de-Toro M, 2005, ENDOCRINOLOGY, V146, P4138, DOI 10.1210/en.2005-0340
   Murata M, 2018, BIOTECHNOL ADV, V36, P311, DOI 10.1016/j.biotechadv.2017.12.002
   Musso G, 2011, ANN MED, V43, P617, DOI 10.3109/07853890.2010.518623
   Neuschwander-Tetri BA, 2017, BMC MED, V15, DOI 10.1186/s12916-017-0806-8
   Nicolucci C, 2017, J PHARMACEUT BIOMED, V140, P105, DOI 10.1016/j.jpba.2017.02.058
   Piao XM, 2019, SPECTROCHIM ACTA A, V221, DOI 10.1016/j.saa.2019.117149
   Polyzos SA, 2012, CURR MOL MED, V12, P68
   Pupo M, 2012, ENVIRON HEALTH PERSP, V120, P1177, DOI 10.1289/ehp.1104526
   Reddivari L, 2017, MSYSTEMS, V2, DOI 10.1128/mSystems.00093-17
   Sargis RM, 2012, BBA-MOL BASIS DIS, V1822, P952, DOI 10.1016/j.bbadis.2012.02.015
   Sharp KPH, 2018, JGH OPEN, V2, P59, DOI 10.1002/jgh3.12040
   Signorile Pietro G, 2012, Front Biosci (Elite Ed), V4, P1724
   Soriano S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031109
   Stewart S., 2018, SHERLOCKS DIS LIVER, V13th ed., P494
   Stiuso P, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/169216
   Strakovsky RS, 2015, TOXICOL APPL PHARM, V284, P101, DOI 10.1016/j.taap.2015.02.021
   Thoene M, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18122726
   Tilg H, 2017, NAT REV GASTRO HEPAT, V14, P32, DOI 10.1038/nrgastro.2016.147
   Tsutsui T, 1998, INT J CANCER, V75, P290, DOI 10.1002/(SICI)1097-0215(19980119)75:2<290::AID-IJC19>3.0.CO;2-H
   Valenti L, 2008, DIABETES, V57, P1355, DOI 10.2337/db07-0714
   Vandenberg LN, 2007, REPROD TOXICOL, V24, P139, DOI 10.1016/j.reprotox.2007.07.010
   Weinhouse C, 2014, ENVIRON HEALTH PERSP, V122, P485, DOI 10.1289/ehp.1307449
   Wetherill YB, 2002, MOL CANCER THER, V1, P515
   Xin LL, 2015, ENVIRON TOXICOL PHAR, V40, P524, DOI 10.1016/j.etap.2015.08.002
   Yarana C, 2019, REDOX BIOL, V26, DOI 10.1016/j.redox.2019.101237
   Younossi ZM, 2017, HEPATOL COMMUN, V1, P421, DOI 10.1002/hep4.1054
   Zhang KS, 2014, BIOMED PHARMACOTHER, V68, P1037, DOI 10.1016/j.biopha.2014.09.003
NR 72
TC 44
Z9 44
U1 3
U2 22
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-7827
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD SEP 1
PY 2019
VL 16
IS 17
AR 3134
DI 10.3390/ijerph16173134
PG 16
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA IZ4EQ
UT WOS:000487037500129
PM 31466361
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Chen, YC
   Sheen, JM
   Tiao, MM
   Tain, YL
   Huang, LT
AF Chen, Yu-Chieh
   Sheen, Jiunn-Ming
   Tiao, Miao-Meng
   Tain, You-Lin
   Huang, Li-Tung
TI Roles of Melatonin in Fetal Programming in Compromised Pregnancies
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE melatonin; epigenetic; fetal programming; redox; pregnancy
ID ALTERED EPIGENETIC REGULATION; BROWN ADIPOSE-TISSUE; OXIDATIVE STRESS;
   GLUCOCORTICOID-RECEPTOR; DEVELOPMENTAL ORIGINS; METABOLIC SYNDROME;
   PINEAL-GLAND; MATERNAL PINEALECTOMY; VASCULAR DYSFUNCTION; ANTIOXIDANT
   ENZYMES
AB Compromised pregnancies such as those associated with gestational diabetes mellitus, intrauterine growth retardation, preeclampsia, maternal undernutrition, and maternal stress may negatively affect fetal development. Such pregnancies may induce oxidative stress to the fetus and alter fetal development through the epigenetic process that may affect development at a later stage. Melatonin is an oxidant scavenger that reverses oxidative stress during the prenatal period. Moreover, the role of melatonin in epigenetic modifications in the field of developmental programming has been studied extensively. Here, we describe the physiological function of melatonin in pregnancy and discuss the roles of melatonin in fetal programming in compromised pregnancies, focusing on its involvement in redox and epigenetic mechanisms.
C1 [Chen, Yu-Chieh; Sheen, Jiunn-Ming; Tiao, Miao-Meng; Tain, You-Lin; Huang, Li-Tung] Chang Gung Univ, Dept Pediat, Kaohsiung Chang Gung Mem Hosp, Coll Med, Kaohsiung 833, Taiwan.
   [Tain, You-Lin] Chang Gung Univ, Ctr Translat Res Biomed Sci, Kaohsiung Chang Gung Mem Hosp, Coll Med, Kaohsiung 833, Taiwan.
   [Huang, Li-Tung] Chang Gung Univ, Dept Tradit Chinese Med, Linkow 333, Taiwan.
C3 Chang Gung University; Chang Gung Memorial Hospital; Chang Gung
   University; Chang Gung Memorial Hospital
RP Huang, LT (corresponding author), Chang Gung Univ, Dept Pediat, Kaohsiung Chang Gung Mem Hosp, Coll Med, Kaohsiung 833, Taiwan.
EM gesicht27@gmail.com; ray.sheen@gmail.com; pc006581@yahoo.com.tw;
   tainyl@hotmail.com; huang_li@pie.com.tw
RI Tsai, Ming/ABA-9806-2020; Tain, You-Lin/H-2827-2019
OI Tain, You-Lin/0000-0002-7059-6407; Tiao, Mao-Meng/0000-0002-0338-3495
FU Chang Gung Memorial Hospital, Kaohsiung, Taiwan [CMRPG8B0301]
FX The study was supported by the grant CMRPG8B0301 from Chang Gung
   Memorial Hospital, Kaohsiung, Taiwan to Li-Tung Huang.
CR Acuña-Castroviejo D, 2001, J PINEAL RES, V30, P65, DOI 10.1034/j.1600-079X.2001.300201.x
   Agil A, 2011, J PINEAL RES, V50, P207, DOI 10.1111/j.1600-079X.2010.00830.x
   Allan SM, 2001, NAT REV NEUROSCI, V2, P734, DOI 10.1038/35094583
   Aversa S, 2012, J MATERN-FETAL NEO M, V25, P207, DOI 10.3109/14767058.2011.573827
   BARKER DJP, 1989, LANCET, V2, P577
   Basta M, 2007, SLEEP MED CLIN, V2, P279, DOI 10.1016/j.jsmc.2007.04.002
   Bellavía SL, 2006, PHYSIOL BEHAV, V89, P342, DOI 10.1016/j.physbeh.2006.06.018
   Biri A, 2007, GYNECOL OBSTET INVES, V64, P187, DOI 10.1159/000106488
   Bogdarina I, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009237
   BROWNLEE M, 1995, CLIN INVEST MED, V18, P275
   BRZEZINSKI A, 1987, J CLIN ENDOCR METAB, V64, P865, DOI 10.1210/jcem-64-4-865
   Burdge GC, 2007, BRIT J NUTR, V97, P1036, DOI 10.1017/S0007114507682920
   Cagampang FR, 2011, BRAIN BEHAV IMMUN, V25, P214, DOI 10.1016/j.bbi.2010.09.005
   Cambonie G, 2007, AM J PHYSIOL-REG I, V292, pR1236, DOI 10.1152/ajpregu.00227.2006
   Cardinali DP, 2013, HORM BEHAV, V63, P322, DOI 10.1016/j.yhbeh.2012.02.020
   Cerda S, 1997, MUTAT RES-REV MUTAT, V386, P141, DOI 10.1016/S1383-5742(96)00050-6
   CHAN WY, 1994, J NEURAL TRANSM-GEN, V96, P19, DOI 10.1007/BF01277925
   Chen M, 2011, DRUG DISCOV TODAY, V16, P1007, DOI 10.1016/j.drudis.2011.09.008
   Chen YC, 2012, J FORMOS MED ASSOC, V111, P57, DOI 10.1016/j.jfma.2011.11.024
   Chim SSC, 2005, P NATL ACAD SCI USA, V102, P14753, DOI 10.1073/pnas.0503335102
   Chowdhury I, 2008, INDIAN J BIOCHEM BIO, V45, P289
   Chung SSM, 2003, J AM SOC NEPHROL, V14, pS233, DOI 10.1097/01.ASN.0000077408.15865.06
   Croteau A, 2006, AM J PUBLIC HEALTH, V96, P846, DOI 10.2105/AJPH.2004.058552
   Darnaudéry M, 2008, BRAIN RES REV, V57, P571, DOI 10.1016/j.brainresrev.2007.11.004
   DEGUCHI T, 1975, P NATL ACAD SCI USA, V72, P2814, DOI 10.1073/pnas.72.7.2814
   Dodge NN, 2001, J CHILD NEUROL, V16, P581, DOI 10.2310/7010.2001.16810
   Dokras A, 2006, MOL HUM REPROD, V12, P611, DOI 10.1093/molehr/gal074
   Dubocovich ML, 2010, PHARMACOL REV, V62, P343, DOI 10.1124/pr.110.002832
   Dugovic C, 1999, J NEUROSCI, V19, P8656
   Durán P, 2005, NUTR NEUROSCI, V8, P167, DOI 10.1080/10284150400026117
   Facciolá G, 2001, EUR J CLIN PHARMACOL, V56, P881, DOI 10.1007/s002280000245
   Ferreira DS, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038795
   Forsén T, 2000, ANN INTERN MED, V133, P176, DOI 10.7326/0003-4819-133-3-200008010-00008
   Fowden AL, 2006, PHYSIOLOGY, V21, P29, DOI 10.1152/physiol.00050.2005
   Fu Q, 2006, FASEB J, V20, P2127, DOI 10.1096/fj.06-6179fje
   Gao L, 2009, CARDIOVASC RES, V82, P9, DOI 10.1093/cvr/cvp031
   Garcia-Vargas L, 2012, CARDIORENAL MED, V2, P134, DOI 10.1159/000337734
   Gheorghe CP, 2010, INT J DEV BIOL, V54, P507, DOI 10.1387/ijdb.082770cg
   Gitto E, 2004, J PINEAL RES, V36, P250, DOI 10.1111/j.1600-079X.2004.00124.x
   Gitto E, 2011, J PINEAL RES, V50, P21, DOI 10.1111/j.1600-079X.2010.00814.x
   Gitto E, 2009, J PINEAL RES, V46, P128, DOI 10.1111/j.1600-079X.2008.00649.x
   Giugliano D, 1996, DIABETES CARE, V19, P257, DOI 10.2337/diacare.19.3.257
   Gordon N, 2000, BRAIN DEV-JPN, V22, P213, DOI 10.1016/S0387-7604(00)00120-0
   Gupta Piyush, 2004, BMC Pediatr, V4, P14, DOI 10.1186/1471-2431-4-14
   Hanson M, 2011, PROG BIOPHYS MOL BIO, V106, P272, DOI 10.1016/j.pbiomolbio.2010.12.008
   Hardeland R, 2006, INT J BIOCHEM CELL B, V38, P313, DOI 10.1016/j.biocel.2005.08.020
   Hardeland R, 2003, J PINEAL RES, V34, P233, DOI 10.1034/j.1600-079X.2003.00040.x
   Hardeland R, 2011, PROG NEUROBIOL, V93, P350, DOI 10.1016/j.pneurobio.2010.12.004
   Hardeland R, 2009, J PINEAL RES, V47, P109, DOI 10.1111/j.1600-079X.2009.00701.x
   Hitchler MJ, 2007, FREE RADICAL BIO MED, V43, P1023, DOI 10.1016/j.freeradbiomed.2007.06.027
   Hochberg Z, 2011, ENDOCR REV, V32, P159, DOI 10.1210/er.2009-0039
   Holditch-Davis D, 1998, DEV PSYCHOBIOL, V33, P257, DOI 10.1002/(SICI)1098-2302(199811)33:3<257::AID-DEV6>3.0.CO;2-Q
   Huang LT, 2012, INT J MOL SCI, V13, P14606, DOI 10.3390/ijms131114606
   Jahnke G, 1999, TOXICOL SCI, V50, P271, DOI 10.1093/toxsci/50.2.271
   Jan JE, 1999, DEV MED CHILD NEUROL, V41, P491, DOI 10.1017/S0012162299001061
   Jin LZ, 2004, J OCCUP ENVIRON MED, V46, P1144, DOI 10.1097/01.jom.0000145168.21614.21
   Karowicz-Bilinska A, 2007, FREE RADICAL RES, V41, P870, DOI 10.1080/10715760701291647
   KARSCH FJ, 1984, RECENT PROG HORM RES, V40, P185
   Kawai Y, 2011, J BIOL CHEM, V286, P7629, DOI 10.1074/jbc.M110.208173
   Ke X, 2006, PHYSIOL GENOMICS, V25, P16, DOI 10.1152/physiolgenomics.00093.2005
   Kennaway DJ, 1996, J CLIN ENDOCR METAB, V81, P1525, DOI 10.1210/jc.81.4.1525
   Kennaway DJ, 2002, TRENDS ENDOCRIN MET, V13, P398, DOI 10.1016/S1043-2760(02)00692-6
   Korkmaz A, 2008, J PINEAL RES, V44, P41, DOI 10.1111/j.1600-079X.2007.00509.x
   Korkmaz A, 2012, GENE, V503, P1, DOI 10.1016/j.gene.2012.04.040
   Korkmaz A, 2009, BREAST CANCER RES TR, V115, P13, DOI 10.1007/s10549-008-0103-5
   Kulkarni A, 2011, DNA CELL BIOL, V30, P79, DOI 10.1089/dna.2010.1084
   Lanoix D, 2012, J PINEAL RES, V53, P417, DOI 10.1111/j.1600-079X.2012.01012.x
   LEACH CM, 1980, PROSTAG OTH LIPID M, V20, P51, DOI 10.1016/0090-6980(80)90005-2
   Lemley CO, 2012, AM J PHYSIOL-REG I, V302, pR454, DOI 10.1152/ajpregu.00407.2011
   Li Y, 2012, PROG NEUROBIOL, V98, P145, DOI 10.1016/j.pneurobio.2012.05.010
   Liao SY, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0040113
   Lillycrop KA, 2006, P NUTR SOC, V65, p65A
   Lillycrop KA, 2007, BRIT J NUTR, V97, P1064, DOI 10.1017/S000711450769196X
   Longtine MS, 2011, SEMIN REPROD MED, V29, P187, DOI 10.1055/s-0031-1275515
   Lui CC, 2011, NEUROCHEM INT, V58, P434, DOI 10.1016/j.neuint.2011.01.002
   Luo ZC, 2006, MED HYPOTHESES, V66, P38, DOI 10.1016/j.mehy.2005.08.020
   Luo ZC, 2010, WORLD J DIABETES, V1, P89, DOI 10.4239/wjd.v1.i3.89
   Maggioni Cristina, 1999, Neuro Endocrinol Lett, V20, P55
   Mairesse Jerome, 2013, Int J Neuropsychopharmacol, V16, P323, DOI 10.1017/S1461145711001970
   Malpaux B, 2002, REPRODUCTION, P167
   Mandruzzato G, 2008, J PERINAT MED, V36, P277, DOI 10.1515/JPM.2008.050
   Matrisciano F, 2012, NEUROPSYCHOPHARMACOL, V37, P929, DOI 10.1038/npp.2011.274
   Matsuzuka T, 2005, J PINEAL RES, V39, P217, DOI 10.1111/j.1600-079X.2005.00260.x
   Mauriz JL, 2013, J PINEAL RES, V54, P1, DOI 10.1111/j.1600-079X.2012.01014.x
   McCurdy CE, 2009, J CLIN INVEST, V119, P323, DOI 10.1172/JCI32661
   McElhinny AS, 1996, J PINEAL RES, V21, P44, DOI 10.1111/j.1600-079X.1996.tb00269.x
   MCMILLEN IC, 1989, J ENDOCRINOL, V120, P459, DOI 10.1677/joe.0.1200459
   MCMILLEN IC, 1995, J REPROD FERTIL, P137
   Mendez N, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0042713
   Miehle K, 2012, CLIN ENDOCRINOL, V76, P2, DOI 10.1111/j.1365-2265.2011.04234.x
   Miller SL, 2012, NEUROENDOCRINOLOGY, V96, P13, DOI 10.1159/000336378
   Mirick DK, 2008, CANCER EPIDEM BIOMAR, V17, P3306, DOI 10.1158/1055-9965.EPI-08-0605
   Mirmiran M, 2003, SLEEP MED REV, V7, P321, DOI 10.1053/smrv.2002.0243
   Mohn A, 2007, J CLIN ENDOCR METAB, V92, P1372, DOI 10.1210/jc.2006-1344
   Morley-Fletcher S, 2011, PSYCHOPHARMACOLOGY, V217, P301, DOI 10.1007/s00213-011-2280-x
   Muñoz-Hoyos A, 2007, NEONATOLOGY, V92, P209, DOI 10.1159/000102957
   MUNOZHOYOS A, 1992, J PINEAL RES, V13, P184, DOI 10.1111/j.1600-079X.1992.tb00074.x
   Nagai R, 2008, J PINEAL RES, V45, P271, DOI 10.1111/j.1600-079X.2008.00586.x
   Nelissen ECM, 2011, HUM REPROD UPDATE, V17, P397, DOI 10.1093/humupd/dmq052
   Nistala R, 2011, CARDIORENAL MED, V1, P243, DOI 10.1159/000332756
   Noris M, 2005, NAT CLIN PRACT NEPHR, V1, P98, DOI 10.1038/ncpneph0035
   Okatani Y, 2002, J PINEAL RES, V33, P127, DOI 10.1034/j.1600-079X.2002.02109.x
   Okatani Y, 2001, J PINEAL RES, V30, P199, DOI 10.1034/j.1600-079X.2001.300402.x
   Owens Judith A, 2004, Curr Probl Pediatr Adolesc Health Care, V34, P154, DOI 10.1016/j.cppeds.2003.10.003
   Painter RC, 2006, AM J CLIN NUTR, V84, P322
   Patterson AJ, 2012, CARDIOVASC RES, V93, P302, DOI 10.1093/cvr/cvr322
   Pilgaard K, 2011, J CLIN ENDOCR METAB, V96, P2835, DOI 10.1210/jc.2011-0577
   Pinney SE, 2012, CURR DIABETES REP, V12, P67, DOI 10.1007/s11892-011-0248-1
   Radogna F, 2010, BIOCHEM PHARMACOL, V80, P1844, DOI 10.1016/j.bcp.2010.07.041
   Raychaudhuri N, 2008, J BIOL CHEM, V283, P13611, DOI 10.1074/jbc.M800128200
   Reiter RJ, 2000, J BIOMED SCI, V7, P444, DOI 10.1159/000025480
   Reiter RJ, 2002, MECH AGEING DEV, V123, P1007, DOI 10.1016/S0047-6374(01)00384-0
   Reiter RJ, 2000, ANN NY ACAD SCI, V917, P376
   Reiter RJ, 2009, BIOL REPROD, V81, P445, DOI 10.1095/biolreprod.108.075655
   Reiter RJ, 2008, NEUROENDOCRINOL LETT, V29, P609
   REPPERT SM, 1988, SCIENCE, V242, P78, DOI 10.1126/science.2845576
   Rexhaj E, 2011, AM J PHYSIOL-HEART C, V301, pH247, DOI 10.1152/ajpheart.01309.2010
   Ribatti D, 2009, ANGIOGENESIS, V12, P101, DOI 10.1007/s10456-008-9125-1
   Richter HG, 2009, J PINEAL RES, V46, P357, DOI 10.1111/j.1600-079X.2009.00671.x
   Rodriguez C, 2004, J PINEAL RES, V36, P1, DOI 10.1046/j.1600-079X.2003.00092.x
   Rugg-Gunn PJ, 2012, REPROD BIOMED ONLINE, V25, P21, DOI 10.1016/j.rbmo.2012.01.012
   SADOWSKY DW, 1991, ENDOCRINOLOGY, V128, P1812, DOI 10.1210/endo-128-4-1812
   Saito S, 2005, BEHAV BRAIN RES, V165, P197, DOI 10.1016/j.bbr.2005.06.045
   SANDYK R, 1992, INT J NEUROSCI, V62, P243
   Seabra WDV, 2000, J PINEAL RES, V29, P193
   Serón-Ferré M, 2001, SEMIN PERINATOL, V25, P363, DOI 10.1053/sper.2001.29037
   Serón-Ferré M, 2012, MOL CELL ENDOCRINOL, V349, P68, DOI 10.1016/j.mce.2011.07.039
   Simmons D, 2010, PRACTICAL MANUAL OF DIABETES IN PREGNANCY, P3
   Simmons RA, 2009, PEDIATR CLIN N AM, V56, P449, DOI 10.1016/j.pcl.2009.03.004
   Simonneaux V, 2011, ENDOCRINOLOGY, V152, P1734, DOI 10.1210/en.2011-0226
   Soumyarani VS, 2012, MOL CELL BIOCHEM, V366, P277, DOI 10.1007/s11010-012-1306-y
   Stevens A, 2010, ENDOCRINOLOGY, V151, P3652, DOI 10.1210/en.2010-0094
   Sun Z, 2009, MOL CELL BIOL, V29, P2658, DOI 10.1128/MCB.01639-08
   Suter M, 2011, FASEB J, V25, P714, DOI 10.1096/fj.10-172080
   Tamura H, 2008, REPROD TOXICOL, V25, P291, DOI 10.1016/j.reprotox.2008.03.005
   Tamura H, 2012, J OVARIAN RES, V5, DOI 10.1186/1757-2215-5-5
   Tan DX, 2011, OBES REV, V12, P167, DOI 10.1111/j.1467-789X.2010.00756.x
   Tan DX, 2000, BIOL SIGNAL RECEPT, V9, P137
   Tarry-Adkins JL, 2011, AM J CLIN NUTR, V94, p1765S, DOI 10.3945/ajcn.110.000620
   Thompson LP, 2012, J PREGNANCY, V2012, DOI 10.1155/2012/582748
   Torres-Farfan C, 2004, J PHYSIOL-LONDON, V554, P841, DOI 10.1113/jphysiol.2003.056465
   Torres-Farfan C, 2008, J PHYSIOL-LONDON, V586, P4017, DOI 10.1113/jphysiol.2008.154351
   Weinstock M, 2001, PROG NEUROBIOL, V65, P427, DOI 10.1016/S0301-0082(01)00018-1
   Wu YH, 2006, J COMP NEUROL, V499, P897, DOI 10.1002/cne.21152
   Xiong F., 2012, FRONT NEUROENDOCRIN, V12, P62
   YELLON SM, 1988, BIOL REPROD, V39, P1093, DOI 10.1095/biolreprod39.5.1093
   YELLON SM, 1987, AM J PHYSIOL, V252, pE799, DOI 10.1152/ajpendo.1987.252.6.E799
   Yuen RKC, 2013, EPIGENETICS-US, V8, P192, DOI 10.4161/epi.23400
   Ziech D, 2011, MUTAT RES-FUND MOL M, V711, P167, DOI 10.1016/j.mrfmmm.2011.02.015
NR 149
TC 71
Z9 74
U1 0
U2 28
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2013
VL 14
IS 3
BP 5380
EP 5401
DI 10.3390/ijms14035380
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 112RH
UT WOS:000316609800052
PM 23466884
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Portugal-Nunes, C
   Reis, J
   Coelho, A
   Moreira, PS
   Castanho, TC
   Magalhaes, R
   Marques, P
   Soares, JM
   Amorim, L
   Cunha, PG
   Santos, NC
   Costa, P
   Palha, JA
   Sousa, N
   Bessa, JM
AF Portugal-Nunes, Carlos
   Reis, Joana
   Coelho, Ana
   Moreira, Pedro Silva
   Castanho, Teresa Costa
   Magalhaes, Ricardo
   Marques, Paulo
   Soares, Jose Miguel
   Amorim, Liliana
   Cunha, Pedro Guimaraes
   Santos, Nadine Correia
   Costa, Patricio
   Palha, Joana Almeida
   Sousa, Nuno
   Bessa, Joao Miguel
TI The Association of Metabolic Dysfunction and Mood Across Lifespan
   Interacts With the Default Mode Network Functional Connectivity
SO FRONTIERS IN AGING NEUROSCIENCE
LA English
DT Article
DE metabolic dysfunction; mood; age; functional connectivity; default mode
   network
ID MAJOR DEPRESSIVE DISORDER; LOW BLOOD-PRESSURE; BODY-MASS INDEX;
   INSULIN-RESISTANCE; METAANALYSIS; ANXIETY; RISK; DISEASE; OBESITY;
   HEALTH
AB Background: Numerous studies suggest a relationship between depression and metabolic syndrome, which is likely influenced by age. Interestingly, functional imaging analysis has shown an association between functional connectivity in the default mode network (DMN-FC) and components of metabolic syndrome, which is explored in this study.
   Methods: From a larger longitudinal cohort study on healthy aging, 943 individuals were extensively characterized for mood and cognition. Among these, 120 individuals who were selected for displaying extreme cognitive performance within the normal range (good and poor performers) were further studied. Here, in a cross-sectional design, using confirmatory factor analysis (CFA), the association between metabolic dysfunction and depressive mood as a function of age and its relationship with DMN-FC was studied.
   Results: Metabolic dysfunction was modeled as a second-order latent variable using CFA. First-order latent variables were obesity, glucose dysmetabolism, lipids imbalance, and blood pressure. Using multiple linear regression models, this study observed that metabolic dysfunction, glucose dysmetabolism, and lipids imbalance were linearly associated with depressive mood, and the association with obesity was U-shaped. The association of metabolic dysfunction, obesity, and glucose dysmetabolism with depressive mood is positive for the younger individuals in our sample and vanishes with aging. The FC of the right superior temporal gyrus with the DMN correlated with both obesity and depressive mood. In participants with higher obesity scores, FC increased with higher GDS scores, while in those with lower GDS scores, FC decreased. Age and blood pressure were associated with a more complex pattern of association between FC of the right supramarginal gyrus and GDS score.
   Conclusion: The association of metabolic dysfunction with depressive mood is influenced by age and relates with differential patterns of DMN-FC. The combination of the effects of age, mood, and metabolic dysfunction is likely to explain the heterogeneity of DMN-FC, which deserves further investigation with larger and longitudinal studies.
C1 [Portugal-Nunes, Carlos; Reis, Joana; Coelho, Ana; Moreira, Pedro Silva; Castanho, Teresa Costa; Magalhaes, Ricardo; Marques, Paulo; Soares, Jose Miguel; Amorim, Liliana; Cunha, Pedro Guimaraes; Santos, Nadine Correia; Costa, Patricio; Palha, Joana Almeida; Sousa, Nuno; Bessa, Joao Miguel] Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, Braga, Portugal.
   [Portugal-Nunes, Carlos; Reis, Joana; Coelho, Ana; Moreira, Pedro Silva; Castanho, Teresa Costa; Magalhaes, Ricardo; Marques, Paulo; Soares, Jose Miguel; Amorim, Liliana; Cunha, Pedro Guimaraes; Santos, Nadine Correia; Costa, Patricio; Palha, Joana Almeida; Sousa, Nuno; Bessa, Joao Miguel] PT Govt Assoc Lab, ICVS 3Bs, Braga, Portugal.
   [Portugal-Nunes, Carlos; Reis, Joana; Coelho, Ana; Moreira, Pedro Silva; Castanho, Teresa Costa; Magalhaes, Ricardo; Marques, Paulo; Soares, Jose Miguel; Amorim, Liliana; Santos, Nadine Correia; Costa, Patricio; Palha, Joana Almeida; Sousa, Nuno; Bessa, Joao Miguel] Clin Acad Ctr Braga, Braga, Portugal.
   [Moreira, Pedro Silva] Univ Minho, Sch Psychol, CIPsi, Psychol Neurosci Lab, Braga, Portugal.
   [Cunha, Pedro Guimaraes] Ctr Hosp Alto Ave EPE, Guimaraes, Portugal.
C3 Universidade do Minho; Laboratorio Associado ICVS 3B's; Universidade do
   Minho
RP Bessa, JM (corresponding author), Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, Braga, Portugal.; Bessa, JM (corresponding author), PT Govt Assoc Lab, ICVS 3Bs, Braga, Portugal.; Bessa, JM (corresponding author), Clin Acad Ctr Braga, Braga, Portugal.
EM joaobessa@med.uminho.pt
RI Amorim, Liliana/Q-7807-2019; Moreira, Pedro/E-4471-2018; Junior,
   Jose/KHC-8978-2024; Sousa, Nuno/N-9137-2017; Cunha, Pedro/AAE-6732-2019;
   Palha, Joana/C-2745-2009; Magalhães, Ricardo/Q-7995-2018; Coelho,
   Ana/T-5310-2018; Castanho, Teresa/T-5279-2018; Cunha, Pedro/K-6743-2014;
   Costa, Patricio/A-3072-2013; Bessa, Joao/K-8079-2014; Correia Santos,
   Nadine/K-7431-2015; Portugal-Nunes, Carlos/AGW-4051-2022
OI Coelho, Ana/0000-0001-8489-5750; Castanho, Teresa/0000-0002-4162-0359;
   Cunha, Pedro/0000-0002-8518-4130; Costa, Patricio/0000-0002-1201-9177;
   Reis, Joana/0000-0002-1240-6388; Bessa, Joao/0000-0001-6385-2452;
   Correia Santos, Nadine/0000-0001-8110-7173; Portugal-Nunes,
   Carlos/0000-0001-8398-1366; Soares, Jose Miguel/0000-0001-6558-4973;
   Amorim, Liliana/0000-0002-5105-7045
FU Foundation for Science and Technology (FCT) [UIDB/50026/2020,
   UIDP/50026/2020]; Norte Portugal Regional Operational Programme (NORTE
   2020), under the PORTUGAL 2020 Partnership Agreement, through the
   European Regional Development Fund (ERDF) [NORTE-01-0145-FEDER-000013,
   NORTE-01-0145-FEDER-000023]; European Commission (FP7) SwitchBox
   [HEALTH-F2-2010-259772]; Portuguese North Regional Operational Program
   (ON.2-O Novo Norte) under the National Strategic Reference Framework
   (QREN), through the European Regional Development Fund (FEDER); Fundacao
   Calouste Gulbenkian-Inovar em Saude (Envelhecimento cognitivo
   saudavel-proporcionar saude mental no processo biologico do
   envelhecimento) [P-139977]; Portuguese Foundation for Science and
   Technology (FCT) [PTDC/DTP-PIC/6936/2014, SFRH/BD/90078/2012,
   SFRH/BD/101398/2014]; Portuguese Science Foundation (FCT)
   [PD/BD/106050/2015]; NORTE 2020 [UMINHO/BD/51/2017]; FCT from PhDiHES
   program [PDE/BDE/113601/2015, PDE/BDE/113602/2015, PDE/BDE/113604/2015];
   Fundacao Calouste Gulbenkian (Portugal) [P-139977]; Research
   Assistantship through the FCT Investigator Programme 2008Ciencia; 
   [NORTE-08-5639-FSE-000041]; Fundação para a Ciência e a Tecnologia
   [PTDC/DTP-PIC/6936/2014, PD/BD/106050/2015, SFRH/BD/101398/2014] Funding
   Source: FCT
FX This work has been funded by National funds, through the Foundation for
   Science and Technology (FCT)-project UIDB/50026/2020 and
   UIDP/50026/2020; and by the projects NORTE-01-0145-FEDER-000013 and
   NORTE-01-0145-FEDER-000023, supported by Norte Portugal Regional
   Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership
   Agreement, through the European Regional Development Fund (ERDF), by the
   European Commission (FP7) SwitchBox (Contract HEALTH-F2-2010-259772)
   project and co-financed by the Portuguese North Regional Operational
   Program (ON.2-O Novo Norte) under the National Strategic Reference
   Framework (QREN), through the European Regional Development Fund
   (FEDER), and by Fundacao Calouste Gulbenkian-Inovar em Saude
   (Envelhecimento cognitivo saudavel-proporcionar saude mental no processo
   biologico do envelhecimento, Contract P-139977) and by the Portuguese
   Foundation for Science and Technology (FCT) under the project
   PTDC/DTP-PIC/6936/2014. CP-N was supported by the Portuguese Science
   Foundation (FCT) doctoral scholarship PD/BD/106050/2015 via
   Inter-University PhD Programme in Aging and Chronic Diseases. JR was
   supported by the FCT fellowship grant with the reference
   PDE/BDE/113602/2015 from the PhDiHES program. AC was supported by a
   scholarship from the project NORTE-08-5639-FSE-000041 (NORTE 2020;
   UMINHO/BD/51/2017). PSM was supported by the FCT fellowship grant with
   the reference PDE/BDE/113601/2015 from the PhDiHES program. TC was a
   recipient of a doctoral fellowship from the Portuguese Foundation for
   Science and Technology (FCT; SFRH/BD/90078/2012). RM was supported by
   the FCT fellowship grant with the reference PDE/BDE/113604/2015 from the
   PhDiHES program. PM was supported by the Fundacao Calouste Gulbenkian
   (Portugal) grant number: P-139977: Better mental health during aging
   based on temporal prediction of individual brain aging trajectories
   (TEMPO). LA was a recipient of a doctoral fellowship from the Portuguese
   Foundation for Science and Technology (FCT; SFRH/BD/101398/2014). NS was
   a recipient of a Research Assistantship through the FCT Investigator
   Programme 2008Ciencia.
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   Andreescu C, 2011, AM J GERIAT PSYCHIAT, V19, P980, DOI 10.1097/JGP.0b013e318227f4f9
   Beydoun MA, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.4
   Beyer F, 2017, HUM BRAIN MAPP, V38, P3502, DOI 10.1002/hbm.23605
   Cha DS, 2014, CNS NEUROL DISORD-DR, V13, P1750
   Damoiseaux JS, 2008, CEREB CORTEX, V18, P1856, DOI 10.1093/cercor/bhm207
   de Wit L, 2010, PSYCHIAT RES, V178, P230, DOI 10.1016/j.psychres.2009.04.015
   de Wit LM, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-14
   Dortland AKBV, 2010, J CLIN PSYCHIAT, V71, P729, DOI 10.4088/JCP.08m04865blu
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Fiske A, 2009, ANNU REV CLIN PSYCHO, V5, P363, DOI 10.1146/annurev.clinpsy.032408.153621
   Flegal KM, 2011, AM J EPIDEMIOL, V173, P1, DOI 10.1093/aje/kwq341
   Gu YC, 2019, HYPERTENS RES, V42, P530, DOI 10.1038/s41440-018-0176-4
   Herrman H, 2019, LANCET, V393, pE42, DOI 10.1016/S0140-6736(18)32408-5
   Hildrum B, 2008, BRIT J PSYCHIAT, V193, P108, DOI 10.1192/bjp.bp.107.045013
   Hildrum B, 2007, J EPIDEMIOL COMMUN H, V61, P53, DOI 10.1136/jech.2005.044966
   Ho RCM, 2008, INT J GERIATR PSYCH, V23, P401, DOI 10.1002/gps.1893
   Huang TL, 2005, J AFFECT DISORDERS, V86, P75, DOI 10.1016/j.jad.2004.11.005
   Instituto Nacional de Estatistica IP, 2011, CENS RES DEF
   Kaiser RH, 2015, JAMA PSYCHIAT, V72, P603, DOI 10.1001/jamapsychiatry.2015.0071
   Kan C, 2013, DIABETES CARE, V36, P480, DOI 10.2337/dc12-1442
   Kim EY, 2015, J AFFECT DISORDERS, V188, P14, DOI 10.1016/j.jad.2015.08.024
   Kim JM, 2011, NEUROBIOL AGING, V32, P336, DOI 10.1016/j.neurobiolaging.2009.02.017
   Kleinridders A, 2015, P NATL ACAD SCI USA, V112, P3463, DOI 10.1073/pnas.1500877112
   Kuk JL, 2010, DIABETES CARE, V33, P2457, DOI 10.2337/dc10-0942
   Lavretsky H, 1998, AM J GERIAT PSYCHIAT, V6, P248
   Lee SH, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.25
   Lenoir H, 2008, J HYPERTENS, V26, P1765, DOI 10.1097/HJH.0b013e3283088d1f
   Levin BE, 2014, J INT NEUROPSYCH SOC, V20, P951, DOI 10.1017/S1355617714000861
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Lustman PJ, 2000, DIABETES CARE, V23, P934, DOI 10.2337/diacare.23.7.934
   Mansur RB, 2015, NEUROSCI BIOBEHAV R, V52, P89, DOI 10.1016/j.neubiorev.2014.12.017
   Mathers C, 2008, GLOBAL BURDEN OF DISEASE: 2004 UPDATE, P1
   Meeks TW, 2011, J AFFECT DISORDERS, V129, P126, DOI 10.1016/j.jad.2010.09.015
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Oda E, 2012, ACTA DIABETOL, V49, P89, DOI 10.1007/s00592-011-0309-6
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Patel V, 2016, LANCET, V387, P1672, DOI 10.1016/S0140-6736(15)00390-6
   Paterniti S, 2000, BRIT J PSYCHIAT, V176, P464, DOI 10.1192/bjp.176.5.464
   Pearson S, 2010, DIABETES CARE, V33, P1128, DOI 10.2337/dc09-1940
   Power JD, 2012, NEUROIMAGE, V59, P2142, DOI 10.1016/j.neuroimage.2011.10.018
   Rasgon NL, 2005, NEUROBIOL AGING, V26, pS103
   Sagud M, 2009, PSYCHIAT RES, V168, P218, DOI 10.1016/j.psychres.2008.06.048
   Santos NC, 2014, FRONT AGING NEUROSCI, V6, DOI 10.3389/fnagi.2014.00021
   Santos NC, 2013, AGE, V35, P1983, DOI 10.1007/s11357-012-9482-y
   Shen BJ, 2006, ANN EPIDEMIOL, V16, P131, DOI 10.1016/j.annepidem.2005.06.049
   Shen BJ, 2003, AM J EPIDEMIOL, V157, P701, DOI 10.1093/aje/kwg045
   Silva N, 2012, CURR PSYCHIAT REP, V14, P8, DOI 10.1007/s11920-011-0245-8
   Soares JM, 2017, BRAIN STRUCT FUNCT, V222, P101, DOI 10.1007/s00429-016-1203-3
   St-Onge MP, 2010, NUTRITION, V26, P152, DOI 10.1016/j.nut.2009.07.004
   Taylor VH, 2010, J OBES, V2010, DOI 10.1155/2010/748048
   Taylor WD, 2013, MOL PSYCHIATR, V18, P963, DOI 10.1038/mp.2013.20
   Tzourio-Mazoyer N, 2002, NEUROIMAGE, V15, P273, DOI 10.1006/nimg.2001.0978
   Vargas HO, 2014, LIFE SCI, V102, P65, DOI 10.1016/j.lfs.2014.02.033
   Whitfield-Gabrieli S, 2012, ANNU REV CLIN PSYCHO, V8, P49, DOI 10.1146/annurev-clinpsy-032511-143049
   Wu MJ, 2011, PSYCHIAT RES-NEUROIM, V194, P39, DOI 10.1016/j.pscychresns.2011.04.003
   Yan CG, 2019, P NATL ACAD SCI USA, V116, P9078, DOI 10.1073/pnas.1900390116
   Yokoyama K, 2015, PSYCHIAT RES, V226, P494, DOI 10.1016/j.psychres.2015.01.026
   Zhang JR, 2011, BIOL PSYCHIAT, V70, P334, DOI 10.1016/j.biopsych.2011.05.018
NR 60
TC 4
Z9 4
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-4365
J9 FRONT AGING NEUROSCI
JI Front. Aging Neurosci.
PD AUG 2
PY 2021
VL 13
AR 618623
DI 10.3389/fnagi.2021.618623
PG 13
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA UL9DA
UT WOS:000692942200001
PM 34408637
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Huang, JY
   Gavin, AR
   Richardson, TS
   Rowhani-Rahbar, A
   Siscovick, DS
   Hochner, H
   Friedlander, Y
   Enquobahrie, DA
AF Huang, Jonathan Y.
   Gavin, Amelia R.
   Richardson, Thomas S.
   Rowhani-Rahbar, Ali
   Siscovick, David S.
   Hochner, Hagit
   Friedlander, Yechiel
   Enquobahrie, Daniel A.
TI Accounting for Life-Course Exposures in Epigenetic Biomarker Association
   Studies: Early Life Socioeconomic Position, Candidate Gene DNA
   Methylation, and Adult Cardiometabolic Risk
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE epigenetic biomarker; life course; marginal structural models;
   methylation; time-dependent confounding
ID MARGINAL STRUCTURAL MODELS; BIRTH-WEIGHT; IN-UTERO;
   GLUCOCORTICOID-RECEPTOR; PRENATAL EXPOSURE; MATERNAL SMOKING; HUMAN
   HYPERTENSION; MASS-SPECTROMETRY; HEALTH; DISEASE
AB Recent studies suggest that epigenetic programming may mediate the relationship between early life environment, including parental socioeconomic position, and adult cardiometabolic health. However, interpreting associations between early environment and adult DNA methylation may be difficult because of time-dependent confounding by life-course exposures. Among 613 adult women (mean age = 32 years) of the Jerusalem Perinatal Study Family Follow-up (2007-2009), we investigated associations between early life socioeconomic position (paternal occupation and parental education) and mean adult DNA methylation at 5 frequently studied cardiometabolic and stress-response genes (ABCA1, INS-IGF2, LEP, HSD11B2, and NR3C1). We used multivariable linear regression and marginal structural models to estimate associations under 2 causal structures for life-course exposures and timing of methylation measurement. We also examined whether methylation was associated with adult cardiometabolic phenotype. Higher maternal education was consistently associated with higher HSD11B2 methylation (e.g., 0.5%-point higher in 9-12 years vs. <= 8 years, 95% confidence interval: 0.1, 0.8). Higher HSD11B2 methylation was also associated with lower adult weight and total and low-density lipoprotein cholesterol. We found that associations with early life socioeconomic position measures were insensitive to different causal assumption; however, exploratory analysis did not find evidence for a mediating role of methylation in socioeconomic position-cardiometabolic risk associations.
C1 [Huang, Jonathan Y.] McGill Univ, Policy, Montreal, PQ, Canada.
   [Gavin, Amelia R.] Univ Washington, Sch Social Work, Seattle, WA 98195 USA.
   [Richardson, Thomas S.] Univ Washington, Dept Stat, Seattle, WA 98195 USA.
   [Siscovick, David S.] New York Acad Med, New York, NY USA.
   [Hochner, Hagit; Friedlander, Yechiel] Hebrew Univ Jerusalem, Hadassah Med Ctr, Braun Sch Publ Hlth, Jerusalem, Israel.
C3 McGill University; University of Washington; University of Washington
   Seattle; University of Washington; University of Washington Seattle; New
   York Academy of Medicine; Hebrew University of Jerusalem; Hadassah
   University Medical Center; Hadassah University Hospital
RP Huang, JY (corresponding author), McGill Univ, Inst Hlth & Social Policy, Montreal Hlth Equ Res Consortium, 1130 Pine Ave West, Montreal, PQ H3A 1A3, Canada.
EM jon.huang@mcgill.ca
RI Huang, Jonathan/J-4139-2019; Richardson, Thomas/HNC-0431-2023; Gavin,
   Amelia/AAX-1229-2021; Hochner, Hagit/KAM-0739-2024
OI Hochner, Hagit/0000-0002-8853-2276; Huang, Jonathan/0000-0002-5901-8403;
   Rowhani-Rahbar, Ali/0000-0002-2705-4485
FU University of Washington Global Women, Adolescents, and Children
   Integrated Health Seed Grant; Israeli Science Foundation [1252/07,
   552/12]; National Institutes of Health [T32HD052462, K01HL103174,
   R01HL088884]; Canadian Institutes of Health Research [115214]
FX This work was supported by the University of Washington Global Women,
   Adolescents, and Children Integrated Health Seed Grant 2013-2014;
   Israeli Science Foundation grants 1252/07 and 552/12; National
   Institutes of Health grants T32HD052462, K01HL103174, and R01HL088884;
   and Canadian Institutes of Health Research operating grant 115214,
   "Ethics, Social Determinants of Health, and Health Equity: Integrating
   Theory and Practice," although no direct funding was received or set
   aside for the writing of this paper.
CR Appleton AA, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0074691
   Baron-Epel O, 2005, ISR MED ASSOC J, V7, P694
   Beach SRH, 2015, FRONT PSYCHOL, V6, DOI 10.3389/fpsyg.2015.00676
   Borghol N, 2012, INT J EPIDEMIOL, V41, P62, DOI 10.1093/ije/dyr147
   Cohen E, 2012, ISR MED ASSOC J, V14, P676
   Conradt E, 2013, EPIGENETICS-US, V8, P1321, DOI 10.4161/epi.26634
   Coolen MW, 2007, NUCLEIC ACIDS RES, V35, DOI 10.1093/nar/gkm662
   Dominguez-Salas P, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4746
   Drake Amanda J, 2011, Pediatr Endocrinol Rev, V9, P566
   Ehrich M, 2005, P NATL ACAD SCI USA, V102, P15785, DOI 10.1073/pnas.0507816102
   Essex MJ, 2013, CHILD DEV, V84, P58, DOI 10.1111/j.1467-8624.2011.01641.x
   Ferrari P, 2010, BBA-MOL BASIS DIS, V1802, P1178, DOI 10.1016/j.bbadis.2009.10.017
   Friso S, 2008, ATHEROSCLEROSIS, V199, P323, DOI 10.1016/j.atherosclerosis.2007.11.029
   Galobardes B, 2008, J EPIDEMIOL COMMUN H, V62, P387, DOI 10.1136/jech.2007.065508
   Gavin AR, 2011, J ADOLESCENT HEALTH, V49, P166, DOI 10.1016/j.jadohealth.2010.11.246
   Gluckman PD, 2008, NEW ENGL J MED, V359, P61, DOI 10.1056/NEJMra0708473
   Gluckman Peter D, 2004, Semin Fetal Neonatal Med, V9, P419, DOI 10.1016/j.siny.2004.03.001
   Gluckman PD, 2009, NAT REV ENDOCRINOL, V5, P401, DOI 10.1038/nrendo.2009.102
   Harlap S, 2007, PAEDIATR PERINAT EP, V21, P256, DOI 10.1111/j.1365-3016.2007.00799.x
   Harris A, 2011, HORM BEHAV, V59, P279, DOI 10.1016/j.yhbeh.2010.06.007
   Harville EW, 2010, ARCH PEDIAT ADOL MED, V164, P533, DOI 10.1001/archpediatrics.2010.61
   Heijmans BT, 2008, P NATL ACAD SCI USA, V105, P17046, DOI 10.1073/pnas.0806560105
   Heijmans BT, 2012, INT J EPIDEMIOL, V41, P74, DOI 10.1093/ije/dyr225
   Hochner H, 2012, CIRCULATION, V125, P1381, DOI 10.1161/CIRCULATIONAHA.111.070060
   Hoffmann A, 2012, EPIGENOMICS-UK, V4, P431, DOI [10.2217/EPI.12.34, 10.2217/epi.12.34]
   Houseman EA, 2014, BIOINFORMATICS, V30, P1431, DOI 10.1093/bioinformatics/btu029
   Huang JY, 2015, AM J EPIDEMIOL, V182, P568, DOI 10.1093/aje/kwv148
   Imai K, 2010, PSYCHOL METHODS, V15, P309, DOI 10.1037/a0020761
   Isralowitz R, 2015, J CHILD ADOL PS NURS, V28, P175, DOI 10.1111/jcap.12126
   Jablonka E, 2004, INT J EPIDEMIOL, V33, P929, DOI 10.1093/ije/dyh231
   Johnson RC, 2011, AM J PUBLIC HEALTH, V101, P2317, DOI 10.2105/AJPH.2011.300252
   Kaluski D N, 2001, J Gend Specif Med, V4, P18
   Kleinhaus K, 2013, BIPOLAR DISORD, V15, P92, DOI 10.1111/bdi.12015
   Lam LL, 2012, P NATL ACAD SCI USA, V109, P17253, DOI 10.1073/pnas.1121249109
   Lanza HI, 2014, AM J HEALTH BEHAV, V38, P708, DOI 10.5993/AJHB.38.5.8
   Lawrence GM, 2014, OBESITY, V22, P1165, DOI 10.1002/oby.20643
   Li LC, 2002, BIOINFORMATICS, V18, P1427, DOI 10.1093/bioinformatics/18.11.1427
   Lumey LH, 2012, INT J EPIDEMIOL, V41, P116, DOI 10.1093/ije/dyr137
   Marsit CJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033794
   Martorell R, 2012, PAEDIATR PERINAT EP, V26, P302, DOI 10.1111/j.1365-3016.2012.01298.x
   Matthews SG, 2010, ENDOCRINOLOGY, V151, P7, DOI 10.1210/en.2009-0916
   McMunn A, 2006, J EPIDEMIOL COMMUN H, V60, P484, DOI 10.1136/jech.2005.042473
   Moodie EEM, 2011, INT J PUBLIC HEALTH, V56, P117, DOI 10.1007/s00038-010-0198-4
   Mulligan CJ, 2012, EPIGENETICS-US, V7, P853, DOI 10.4161/epi.21180
   Nandi A, 2012, EPIDEMIOLOGY, V23, P223, DOI 10.1097/EDE.0b013e31824570bd
   Oberlander TF, 2008, EPIGENETICS-US, V3, P97, DOI 10.4161/epi.3.2.6034
   Obermann-Borst SA, 2012, J DEV ORIG HLTH DIS, V3, P315, DOI 10.1017/S2040174412000293
   Peña CJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039791
   Perroud N, 2011, TRANSL PSYCHIAT, V1, DOI 10.1038/tp.2011.60
   Radtke KM, 2011, TRANSL PSYCHIAT, V1, DOI 10.1038/tp.2011.21
   Reynolds RM, 2013, CLIN ENDOCRINOL, V78, P814, DOI 10.1111/cen.12164
   Reynolds RM, 2013, PSYCHONEUROENDOCRINO, V38, P1, DOI 10.1016/j.psyneuen.2012.08.012
   Richmond RC, 2015, INT J EPIDEMIOL, V44, P1191, DOI 10.1093/ije/dyv066
   Richmond RC, 2015, HUM MOL GENET, V24, P2201, DOI 10.1093/hmg/ddu739
   Richmond RC, 2014, EARLY HUM DEV, V90, P769, DOI 10.1016/j.earlhumdev.2014.08.023
   Sauerbrun-Cutler MT, 2013, SEMIN REPROD MED, V31, P325, DOI 10.1055/s-0033-1348890
   Sharp GC, 2015, INT J EPIDEMIOL, V44, P1288, DOI 10.1093/ije/dyv042
   Stringhini S, 2015, INT J EPIDEMIOL, V44, P1320, DOI 10.1093/ije/dyv060
   Suderman M, 2014, BMC MED GENOMICS, V7, DOI 10.1186/1755-8794-7-13
   Szyf M, 2013, CAN J PSYCHIAT, V58, P697, DOI 10.1177/070674371305801208
   Talens RP, 2012, AGING CELL, V11, P694, DOI 10.1111/j.1474-9726.2012.00835.x
   Talens RP, 2012, INT J EPIDEMIOL, V41, P106, DOI 10.1093/ije/dyr153
   Tehranifar P, 2013, EPIGENETICS-US, V8, P23, DOI 10.4161/epi.22989
   Tobi EW, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0037933
   Tobi EW, 2009, HUM MOL GENET, V18, P4046, DOI 10.1093/hmg/ddp353
   Turan N, 2012, BMC MED GENOMICS, V5, DOI 10.1186/1755-8794-5-10
   US Central Intelligence Agency, WORLD FACTB ISR
   VanderWeele TJ, 2014, EPIDEMIOLOGY, V25, P473, DOI 10.1097/EDE.0000000000000105
   Wells JCK, 2010, AM J HUM BIOL, V22, P1, DOI 10.1002/ajhb.20994
NR 69
TC 25
Z9 28
U1 0
U2 17
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD OCT 1
PY 2016
VL 184
IS 7
BP 520
EP 531
DI 10.1093/aje/kww014
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA EA4AY
UT WOS:000386552000005
PM 27651384
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Lengvenyte, A
   Aouizerate, B
   Aubin, V
   Loftus, J
   Marlinge, E
   Belzeaux, R
   Dubertret, C
   Gard, S
   Haffen, E
   Schwan, R
   Llorca, PM
   Passerieux, C
   Roux, P
   Polosan, M
   Etain, B
   Leboyer, M
   Courtet, P
   Olié, E
AF Lengvenyte, Aiste
   Aouizerate, Bruno
   Aubin, Valerie
   Loftus, Josephine
   Marlinge, Emeline
   Belzeaux, Raoul
   Dubertret, Caroline
   Gard, Sebastien
   Haffen, Emmanuel
   Schwan, Raymund
   Llorca, Pierre-Michel
   Passerieux, Christine
   Roux, Paul
   Polosan, Mircea
   Etain, Bruno
   Leboyer, Marion
   Courtet, Philippe
   Olie, Emilie
CA FondaMental Adv Ctr Expertise Bipo
TI Violent suicide attempt history in elderly patients with bipolar
   disorder: The role of sex, abdominal obesity, and verbal memory: Results
   from the FACE-BD cohort (FondaMental Advanced center of Expertise for
   Bipolar Disorders)
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Suicide; Bipolar disorder; Obesity; Cognitive function; Memory; Cohort
ID BODY-MASS INDEX; METABOLIC SYNDROME; GENDER-DIFFERENCES; WAIST
   CIRCUMFERENCE; COMPLETED SUICIDE; DECISION-MAKING; WEIGHT STIGMA;
   HEALTH; DEPRESSION; STRESS
AB Background: Bipolar disorder (BD) is a chronic, lifelong condition, associated with increased risk of obesity, cognitive impairment, and suicidal behaviors. Abdominal obesity and a higher risk of violent suicide attempt (SA) seem to be shared correlates with older age, BD, and male sex until middle age when menopause-related female body changes occur. This study aimed at assessing the role of abdominal obesity and cognition in the violent SA burden of individuals with BD.
   Methods: From the well-defined nationwide cohort FACE-BD (FondaMental Advanced center of Expertise for Bipolar Disorders), we extracted data on 619 euthymic BD patients that were 50 years or older at inclusion. Cross-sectional clinical, cognitive, and metabolic assessments were performed. SA history was based on self-report.
   Results: Violent SA, in contrast to non-violent and no SA, was associated with higher waist circumference, abdominal obesity and poorer California Verbal Learning Test short-delay free recall (CVLT-SDFR) (ANOVA, p < 001, p = .014, and p = .006). Waist circumference and abdominal obesity were associated with violent SA history independently of sex, BD type and anxiety disorder (Exp(B) 1.02, CI 1.00-1.05, p = .018; Exp(B) 2.16, CI 1.00-4.64, p = .009, accordingly). In an exploratory model, waist circumference and CVLT-SDFR performance mediated the association between male sex and violent SA.
   Limitations: Cross-sectional design and retrospective reporting.
   Conclusions: Violent SA history was associated with abdominal obesity and poorer verbal memory in older age BD patients. These factors were interlinked and might mediate the association between male sex and violent SA.
C1 [Lengvenyte, Aiste; Courtet, Philippe; Olie, Emilie] Univ Montpellier, Dept Emergency Psychiat & Postacute Care, INSERM, CHU Montpellier,IGF,CNRS, 371 Av Doyen Gaston Giraud, F-34090 Montpellier, France.
   [Lengvenyte, Aiste; Aouizerate, Bruno; Loftus, Josephine; Marlinge, Emeline; Belzeaux, Raoul; Dubertret, Caroline; Gard, Sebastien; Haffen, Emmanuel; Schwan, Raymund; Llorca, Pierre-Michel; Passerieux, Christine; Roux, Paul; Polosan, Mircea; Etain, Bruno; Leboyer, Marion; Courtet, Philippe; Olie, Emilie] Fdn FondaMental, Creteil, France.
   [Lengvenyte, Aiste] Vilnius Univ, Fac Med, Inst Clin Med, Psychiat Clin, Vilnius, Lithuania.
   [Aouizerate, Bruno; Gard, Sebastien] Charles Perrens Hosp, Dept Clin & Acad Psychiat, Bordeaux, France.
   [Aouizerate, Bruno] Univ Bordeaux, France NutriNeuro, UMR INRAE 1286, Bordeaux, France.
   [Aubin, Valerie; Loftus, Josephine] Hosp Princess Grace, Psychiat Ctr, Monaco, Monaco.
   [Marlinge, Emeline; Etain, Bruno] Univ Paris, Hop Fernand Widal, AP HP, DMU Neurosci,GHU Paris Nord,INSERM UMRS 1144, Paris, France.
   [Belzeaux, Raoul] AP HM, Pole Psychiat, Marseille, France.
   [Belzeaux, Raoul] Aix Marseille Univ, INT UMR7289, CNRS, Marseille, France.
   [Dubertret, Caroline] Univ Paris, Grp Hosp Univ AP HP Nord, Hop Louis Mourier,AP HP, Serv Psychiat & Addictol,Fac Med,DMU ESPRIT, Colombes, France.
   [Haffen, Emmanuel] Univ Franche Comte, Serv Psychiat Adulte, Lab Neurosci, CHU Besancon,UBFC,CIC 1431 INSERM, Besancon, France.
   [Schwan, Raymund] Univ Lorraine, Pole Hosp Univ Psychiat Adultes Grand Nancy, Ctr Psychotherap Nancy, INSERM U1114, Nancy, France.
   [Llorca, Pierre-Michel] Univ Clermont Auvergne, Dept Psychiat, CHU Clermont Ferrand, EA 7280, Clermont Ferrand, France.
   [Passerieux, Christine; Polosan, Mircea] Univ Paris Saclay, Serv Univ Psychiat Adulte & Addictol, Ctr Hosp Versailles,Le Chesnay,DisAP DevPsy CESP, INSERM UMR1018,Univ Versailles St Quentin En Yvel, F-94807 Villejuif, France.
   [Roux, Paul; Leboyer, Marion] Univ Paris Est Creteil, AP HP, FHU ADAPT,INSERM,IMRB, DMU IMPACT,Fdn FondaMental,Translat Neuropsychiat, F-94010 Creteil, France.
C3 Universite de Montpellier; CHU de Montpellier; Centre National de la
   Recherche Scientifique (CNRS); Institut National de la Sante et de la
   Recherche Medicale (Inserm); Vilnius University; INRAE; Universite de
   Bordeaux; Universite Paris Cite; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP);
   Hopital Universitaire Saint-Louis - APHP; Hopital Universitaire
   Lariboisiere-Fernand-Widal - APHP; Aix-Marseille Universite; Assistance
   Publique-Hopitaux de Marseille; Aix-Marseille Universite; Centre
   National de la Recherche Scientifique (CNRS); CNRS - National Institute
   for Biology (INSB); Assistance Publique Hopitaux Paris (APHP);
   Universite Paris Cite; Hopital Universitaire Louis-Mourier - APHP;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Franche-Comte; CHU Besancon; Universite de Lorraine;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Clermont Auvergne (UCA); CHU Clermont Ferrand; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite
   Paris Saclay; Centre Hospitalier de Versailles; Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Assistance Publique Hopitaux
   Paris (APHP); Hopital Universitaire Henri-Mondor - APHP; Institut
   National de la Sante et de la Recherche Medicale (Inserm)
RP Lengvenyte, A (corresponding author), Univ Montpellier, Dept Emergency Psychiat & Postacute Care, INSERM, CHU Montpellier,IGF,CNRS, 371 Av Doyen Gaston Giraud, F-34090 Montpellier, France.
EM aiste.lengvenyte@chu-montpellier.fr
RI Lengvenyte, Aiste/AAI-1328-2020; Fond, Guillaume/D-7646-2011; Roux,
   Paul/B-5795-2013; Polosan, Mircea/MGV-2270-2025; Schwan,
   Raymund/AAA-5230-2022; Belzeaux, Raoul/AGZ-3125-2022; Etain,
   Bruno/L-6647-2017; haffen, emmanuel/R-2765-2017
OI Aouizerate, Bruno/0000-0002-7092-7747; Lengvenyte,
   Aiste/0000-0001-9715-5145; AUBIN, VALERIE/0000-0002-2444-0954; Etain,
   Bruno/0000-0002-5377-1488; haffen, emmanuel/0000-0002-4091-518X
FU Fondation FondaMental, Creteil, France; Investissements d'Avenir
   programs [ANR-11-IDEX-0004-02, ANR-10-COHO-10-01]
FX This work was supported (in part) by the Fondation FondaMental, Creteil,
   France and by the Investissements d'Avenir programs managed by the ANR
   under references ANR-11-IDEX-0004-02 and ANR-10-COHO-10-01
CR Aguglia A, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00070
   Alacreu-Crespo A, 2020, EUR NEUROPSYCHOPHARM, V36, P50, DOI 10.1016/j.euroneuro.2020.04.006
   Alacreu-Crespo A, 2020, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.00097
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Altamura AC, 2010, EUR ARCH PSY CLIN N, V260, P385, DOI 10.1007/s00406-009-0085-2
   Attwells S, 2017, JAMA PSYCHIAT, V74, P833, DOI 10.1001/jamapsychiatry.2017.1567
   Bakker OB, 2018, NAT IMMUNOL, V19, P776, DOI 10.1038/s41590-018-0121-3
   Bernstein DP, 2003, CHILD ABUSE NEGLECT, V27, P169, DOI 10.1016/S0145-2134(02)00541-0
   Burdick KE, 2020, NEUROPSYCHOPHARMACOL, V45, P1743, DOI 10.1038/s41386-020-0683-2
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1016/0165-1781(89)90047-4
   Caldwell JZK, 2021, BRAIN BEHAV IMMUN, V95, P27, DOI 10.1016/j.bbi.2020.12.001
   Capuzzi E, 2022, CNS SPECTRUMS, V27, P362, DOI 10.1017/S1092852920002199
   Carrus D, 2010, PSYCHOL MED, V40, P1349, DOI 10.1017/S0033291709991644
   Carvalho AF, 2020, TRANSL PSYCHIAT, V10, DOI 10.1038/s41398-020-0835-5
   Crump C, 2013, JAMA PSYCHIAT, V70, P931, DOI 10.1001/jamapsychiatry.2013.1394
   D'Ambrosio V, 2012, PROG NEURO-PSYCHOPH, V37, P136, DOI 10.1016/j.pnpbp.2011.12.009
   Dalkner N, 2018, CLIN NUTR, V37, P1744, DOI 10.1016/j.clnu.2017.06.024
   Del Matto L, 2020, NEUROSCI BIOBEHAV R, V116, P142, DOI 10.1016/j.neubiorev.2020.06.017
   Delis D.C., 2000, Manual for the California Verbal Learning Test, (CVLT-II)
   Depp CA, 2014, BIPOLAR DISORD, V16, P422, DOI 10.1111/bdi.12200
   Di Salvo G, 2020, PSYCHIAT RES, V290, DOI 10.1016/j.psychres.2020.113088
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   Fan HM, 2016, SCI REP-UK, V6, DOI 10.1038/srep21521
   Fernandes BS, 2016, LANCET PSYCHIAT, V3, P1147, DOI 10.1016/S2215-0366(16)30370-4
   First M.B., 2016, User's Guide for the SCID-5-CV Structured Clinical Interview for DSM-5 Disorders: Clinical Version
   Ganança L, 2016, PSYCHONEUROENDOCRINO, V63, P296, DOI 10.1016/j.psyneuen.2015.10.008
   García-Alonso V, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0153751
   Giner L, 2014, J CLIN PSYCHIAT, V75, pE191, DOI 10.4088/JCP.13m08524
   Godefroy O., 2012, BATTERIE GREFEX DONN, P231
   Godin O, 2014, J CLIN PSYCHIAT, V75, P1078, DOI 10.4088/JCP.14m09038
   Golden C, 1978, MANUAL CLIN EXPT USE
   Gomes FA, 2010, ACTA NEUROPSYCHIATR, V22, P63, DOI 10.1111/j.1601-5215.2010.00452.x
   Goossens GH, 2021, NAT REV ENDOCRINOL, V17, P47, DOI 10.1038/s41574-020-00431-8
   Gowey MA, 2019, INT J OBESITY, V43, P615, DOI 10.1038/s41366-018-0270-3
   Henry C, 2011, J AFFECT DISORDERS, V131, P358, DOI 10.1016/j.jad.2010.11.013
   Ibrahim MM, 2010, OBES REV, V11, P11, DOI 10.1111/j.1467-789X.2009.00623.x
   Isaac V, 2011, FRONT AGING NEUROSCI, V3, DOI 10.3389/fnagi.2011.00012
   Isung J, 2014, TRANSL PSYCHIAT, V4, DOI 10.1038/tp.2014.113
   Janssen I, 2002, ARCH INTERN MED, V162, P2074, DOI 10.1001/archinte.162.18.2074
   Kamintsky L, 2020, NEUROIMAGE-CLIN, V26, DOI 10.1016/j.nicl.2019.102049
   Kim AM, 2021, J CLIN PSYCHIAT, V82, P45, DOI 10.4088/JCP.20r13263
   Klatzkin RR, 2019, PHYSIOL BEHAV, V210, DOI 10.1016/j.physbeh.2019.112639
   Lackner N, 2016, WORLD J BIOL PSYCHIA, V17, P535, DOI 10.3109/15622975.2015.1046917
   Lee MJ, 2014, BBA-MOL BASIS DIS, V1842, P473, DOI 10.1016/j.bbadis.2013.05.029
   Lee YN, 2020, BRAIN BEHAV IMMUN, V88, P631, DOI 10.1016/j.bbi.2020.04.063
   Lengvenyte A, 2021, EUR J NEUROSCI, V53, P330, DOI 10.1111/ejn.14635
   Lenz B, 2019, PROG NEUROBIOL, V172, P84, DOI 10.1016/j.pneurobio.2018.06.003
   Lezak MD, 2004, Neuropsychological assessment, V4th
   Llinàs-Reglà J, 2017, ASSESSMENT, V24, P183, DOI 10.1177/1073191115602552
   Mansur RB, 2020, PSYCHONEUROENDOCRINO, V120, DOI 10.1016/j.psyneuen.2020.104779
   Mazza E, 2017, BIPOLAR DISORD, V19, P116, DOI 10.1111/bdi.12484
   McElroy SL, 2016, ACTA PSYCHIAT SCAND, V133, P144, DOI 10.1111/acps.12460
   McHugh CM, 2021, J AFFECT DISORDERS, V281, P289, DOI 10.1016/j.jad.2020.11.077
   Merikangas KR, 2011, ARCH GEN PSYCHIAT, V68, P241, DOI 10.1001/archgenpsychiatry.2011.12
   Miller JN, 2020, CURR PSYCHIAT REP, V22, DOI 10.1007/s11920-020-1130-0
   Minhas PS, 2021, NATURE, V590, P122, DOI 10.1038/s41586-020-03160-0
   Moazzami K, 2020, PSYCHOSOM MED, V82, P272, DOI 10.1097/PSY.0000000000000776
   MONTGOMERY SA, 1979, BRIT J PSYCHIAT, V134, P382, DOI 10.1192/bjp.134.4.382
   Mora E, 2017, J CLIN PSYCHIAT, V78, pE924, DOI 10.4088/JCP.16m10968
   Nassar A, 2014, ACS CHEM NEUROSCI, V5, P451, DOI 10.1021/cn500038f
   Nicol GE, 2018, JAMA PSYCHIAT, V75, P788, DOI 10.1001/jamapsychiatry.2018.1088
   Nivoli AMA, 2011, J AFFECT DISORDERS, V133, P443, DOI 10.1016/j.jad.2011.04.055
   Opel N, 2019, LANCET PSYCHIAT, V6, P318, DOI 10.1016/S2215-0366(19)30044-6
   Owens SJ, 2019, PSYCHIAT RES, V280, DOI 10.1016/j.psychres.2019.112503
   Papadopoulos S, 2015, OBESITY, V23, P1743, DOI 10.1002/oby.21187
   Perrain R, 2021, J AFFECT DISORDERS, V280, P241, DOI 10.1016/j.jad.2020.11.052
   Plans L, 2019, J AFFECT DISORDERS, V242, P111, DOI 10.1016/j.jad.2018.08.054
   Plans L, 2019, J AFFECT DISORDERS, V257, P340, DOI 10.1016/j.jad.2019.07.048
   Poitrenaud J., 2007, Adaptation en langue francaise du California Verbal Learning Test [French language adaptation of the California Verbal Learning Test]
   Preacher KJ, 2008, BEHAV RES METHODS, V40, P879, DOI 10.3758/BRM.40.3.879
   Rodriguez ACI, 2015, PSYCHONEUROENDOCRINO, V62, P301, DOI 10.1016/j.psyneuen.2015.08.014
   Ross R, 2020, NAT REV ENDOCRINOL, V16, P177, DOI 10.1038/s41574-019-0310-7
   Rosso G, 2020, COMPR PSYCHIAT, V96, DOI 10.1016/j.comppsych.2019.152136
   Roux P, 2019, PSYCHOL MED, V49, P519, DOI 10.1017/S0033291718001186
   Rubin DC, 2012, COGNITION EMOTION, V26, P25, DOI 10.1080/02699931.2011.561564
   Salvi V, 2020, J AFFECT DISORDERS, V266, P610, DOI 10.1016/j.jad.2020.01.145
   Schipper HS, 2012, TRENDS ENDOCRIN MET, V23, P407, DOI 10.1016/j.tem.2012.05.011
   Segerstrom SC, 2016, PSYCHOSOM MED, V78, P182, DOI 10.1097/PSY.0000000000000249
   Strassnig M, 2017, BIPOLAR DISORD, V19, P336, DOI 10.1111/bdi.12505
   Tomiyama AJ, 2014, HEALTH PSYCHOL, V33, P862, DOI 10.1037/hea0000107
   Van der Elst W, 2006, ASSESSMENT, V13, P62, DOI 10.1177/1073191105283427
   Van Oyen H, 2013, INT J PUBLIC HEALTH, V58, P143, DOI 10.1007/s00038-012-0361-1
   Villeda SA, 2011, NATURE, V477, P90, DOI 10.1038/nature10357
   Watson KT, 2021, JAMA PSYCHIAT, V78, P439, DOI 10.1001/jamapsychiatry.2020.3669
   Wechsler D, 1997, WAIS-III: Administration and Scoring Manual: Wechsler Adult Intelligence Scale, V3
   Wechsler D, 1955, Frontiers in Psychology
   Westling S, 2004, PSYCHIAT RES, V129, P249, DOI 10.1016/j.psychres.2004.09.004
   Xia L, 2020, PSYCHIAT RES, V284, DOI 10.1016/j.psychres.2019.112669
   Yatham LN, 2010, BIPOLAR DISORD, V12, P351, DOI 10.1111/j.1399-5618.2010.00830.x
   Young KA, 2019, J DIABETES COMPLICAT, V33, P118, DOI 10.1016/j.jdiacomp.2018.10.018
   YOUNG RC, 1978, BRIT J PSYCHIAT, V133, P429, DOI 10.1192/bjp.133.5.429
   Yusufov M, 2021, J AFFECT DISORDERS, V281, P279, DOI 10.1016/j.jad.2020.12.029
   Zalsman G, 2006, BIPOLAR DISORD, V8, P558, DOI 10.1111/j.1399-5618.2006.00381.x
   Zhang RB, 2019, HUM BRAIN MAPP, V40, P3452, DOI 10.1002/hbm.24608
   Zsido RG, 2019, JAMA NETW OPEN, V2, DOI 10.1001/jamanetworkopen.2019.6126
NR 95
TC 7
Z9 7
U1 1
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JAN 1
PY 2022
VL 296
BP 265
EP 276
DI 10.1016/j.jad.2021.09.097
EA OCT 2021
PG 12
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA XO1QU
UT WOS:000729968500034
PM 34606799
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Asghar, ZA
   Thompson, A
   Chi, M
   Cusumano, A
   Scheaffer, S
   Al-Hammadi, N
   Saben, JL
   Moley, KH
AF Asghar, Zeenat A.
   Thompson, Alysha
   Chi, Maggie
   Cusumano, Andrew
   Scheaffer, Suzanne
   Al-Hammadi, Noor
   Saben, Jessica L.
   Moley, Kelle H.
TI Maternal fructose drives placental uric acid production leading to
   adverse fetal outcomes
SO SCIENTIFIC REPORTS
LA English
DT Article
ID OXIDATIVE STRESS; METABOLIC SYNDROME; HEPATIC STEATOSIS; DIETARY
   FRUCTOSE; FATTY LIVER; PREGNANCY; CONSUMPTION; RISK; LACTATION; SUGAR
AB Maternal metabolic diseases increase offspring risk for low birth weight and cardiometabolic diseases in adulthood. Excess fructose consumption may confer metabolic risks for both women and their offspring. However, the direct consequences of fructose intake per se are unknown. We assessed the impact of a maternal high-fructose diet on the fetal-placental unit in mice in the absence of metabolic syndrome and determined the association between maternal serum fructose and placental uric acid levels in humans. In mice, maternal fructose consumption led to placental inefficiency, fetal growth restriction, elevated fetal serum glucose and triglyceride levels. In the placenta, fructose induced de novo uric acid synthesis by activating the activities of the enzymes AMP deaminase and xanthine oxidase. Moreover, the placentas had increased lipids and altered expression of genes that control oxidative stress. Treatment of mothers with the xanthine oxidase inhibitor allopurinol reduced placental uric acid levels, prevented placental inefficiency, and improved fetal weights and serum triglycerides. Finally, in 18 women delivering at term, maternal serum fructose levels significantly correlated with placental uric acid levels. These findings suggest that in mice, excess maternal fructose consumption impairs placental function via a xanthine oxidase/uric acid-dependent mechanism, and similar effects may occur in humans.
C1 [Asghar, Zeenat A.; Thompson, Alysha; Chi, Maggie; Cusumano, Andrew; Scheaffer, Suzanne; Saben, Jessica L.; Moley, Kelle H.] Washington Univ, Sch Med, Dept Obstet & Gynecol, St Louis, MO 63110 USA.
   [Al-Hammadi, Noor] Washington Univ, Sch Med, Dept Biostat, St Louis, MO USA.
C3 Washington University (WUSTL); Washington University (WUSTL)
RP Saben, JL; Moley, KH (corresponding author), Washington Univ, Sch Med, Dept Obstet & Gynecol, St Louis, MO 63110 USA.
EM sabenj@wudosis.wustl.edu; moleyk@wudosis.wustl.edu
RI Saben, Jessica/IUO-1267-2023; Al-Hammadi, Noor/E-5866-2019
OI Al-Hammadi, Noor/0000-0003-1742-6609; Shyr, Zeenat/0000-0001-8710-9938;
   saben, jessica/0000-0002-9873-025X
FU NIH [HD083895, HD065435]; American Diabetes Association; CTSA at
   Washington University [UL1 TR000448]; Thrasher Research Foundation
FX The authors thank Deborah Frank, PhD, Obstetrics and Gynecology,
   Washington University in St. Louis, for critical reading and editing of
   this manuscript. This work was supported by NIH grants HD083895 and
   HD065435 (KHM), a grant from the American Diabetes Association (KHM), a
   grant from the CTSA at Washington University (UL1 TR000448) (KHM, JLS),
   and the Thrasher Research Foundation (JLS).
CR Abdelmalek MF, 2012, HEPATOLOGY, V56, P952, DOI 10.1002/hep.25741
   Alvarez-Lario B, 2011, QJM-INT J MED, V104, P1015, DOI 10.1093/qjmed/hcr159
   Aon MA, 2014, FRONT PHYSIOL, V5, DOI 10.3389/fphys.2014.00282
   Bainbridge SA, 2008, PLACENTA, V29, pS67, DOI 10.1016/j.placenta.2007.11.001
   Bainbridge SA, 2009, AM J PHYSIOL-CELL PH, V297, pC440, DOI 10.1152/ajpcell.00593.2008
   Bartels Ä, 2012, J OBSTET GYNAECOL, V32, P747, DOI 10.3109/01443615.2012.714017
   Bellomo G, 2012, EXPERT REV CARDIOVAS, V10, P701, DOI [10.1586/ERC.12.51, 10.1586/erc.12.51]
   Bibee KP, 2011, REPROD SCI, V18, P20, DOI 10.1177/1933719110380276
   Borgen I, 2012, EUR J CLIN NUTR, V66, P920, DOI 10.1038/ejcn.2012.61
   Clausen T, 2001, AM J OBSTET GYNECOL, V185, P451, DOI 10.1067/mob.2001.116687
   de Oliveira EP, 2012, DIABETOL METAB SYNDR, V4, DOI 10.1186/1758-5996-4-12
   DeBosch BJ, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms5642
   DeBosch BJ, 2014, J BIOL CHEM, V289, P10989, DOI 10.1074/jbc.M113.527002
   Doege H, 2000, J BIOL CHEM, V275, P16275, DOI 10.1074/jbc.275.21.16275
   Fabbrini E, 2015, NUTRIENTS, V7, P4995, DOI 10.3390/nu7064995
   Griendling KK, 2003, CIRCULATION, V108, P1912, DOI 10.1161/01.CIR.0000093660.86242.BB
   Hagström H, 2016, LIVER INT, V36, P268, DOI 10.1111/liv.12902
   HALES CN, 1992, DIABETOLOGIA, V35, P595, DOI 10.1093/ije/dyt133
   Havel PJ, 2005, NUTR REV, V63, P133, DOI [10.1301/nr.2005.may.133-157, 10.1111/j.1753-4887.2005.tb00132.x]
   Ishimoto T, 2012, P NATL ACAD SCI USA, V109, P4320, DOI 10.1073/pnas.1119908109
   JEN KLC, 1991, J NUTR, V121, P1999, DOI 10.1093/jn/121.12.1999
   Jia GH, 2014, CURR HYPERTENS REP, V16, DOI 10.1007/s11906-014-0434-z
   Johnson RJ, 2013, DIABETES, V62, P3307, DOI 10.2337/db12-1814
   Johnson RJ, 2009, ENDOCR REV, V30, P96, DOI 10.1210/er.2008-0033
   Kane AD, 2013, PHYSIOL REP, V1, DOI 10.1002/phy2.156
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   Kelishadi R, 2014, NUTRITION, V30, P503, DOI 10.1016/j.nut.2013.08.014
   Lanaspa MA, 2012, J BIOL CHEM, V287, P40732, DOI 10.1074/jbc.M112.399899
   Lewis RM, 2012, PLACENTA, V33, pS28, DOI 10.1016/j.placenta.2011.12.003
   Lineker C, 2016, REPROD FERT DEVELOP, V28, P2007, DOI 10.1071/RD15119
   Liu W, 2000, J CELL SCI, V113, P635
   Manolescu AR, 2007, MOL MEMBR BIOL, V24, P455, DOI 10.1080/09687680701298143
   Many A, 2000, AM J PATHOL, V156, P321, DOI 10.1016/S0002-9440(10)64733-5
   McMillen IC, 2005, PHYSIOL REV, V85, P571, DOI 10.1152/physrev.00053.2003
   Mukai Y, 2014, CLIN EXP PHARMACOL P, V41, P331, DOI 10.1111/1440-1681.12225
   Murata M, 2013, J REPROD DEVELOP, V59, P7, DOI 10.1262/jrd.2012-053
   Nakagawa T, 2006, AM J PHYSIOL-RENAL, V290, pF625, DOI 10.1152/ajprenal.00140.2005
   Omurtag K, 2015, REPROD SCI, V22, P94, DOI 10.1177/1933719114533727
   Ouyang X, 2008, J HEPATOL, V48, P993, DOI 10.1016/j.jhep.2008.02.011
   Plata MD, 2014, REPROD BIOL ENDOCRIN, V12, P1, DOI 10.1186/1477-7827-12-80
   Poston L, 2004, PLACENTA, V25, pS72, DOI 10.1016/j.placenta.2004.01.003
   Rando OJ, 2015, CELL, V161, P93, DOI 10.1016/j.cell.2015.02.021
   RAWANA S, 1993, J NUTR, V123, P2158
   Roberts JM, 2005, HYPERTENSION, V46, P1263, DOI 10.1161/01.HYP.0000188703.27002.14
   Saben JL, 2016, ENDOCRINOLOGY, V157, P956, DOI 10.1210/en.2015-1618
   Sautin YY, 2007, AM J PHYSIOL-CELL PH, V293, pC584, DOI 10.1152/ajpcell.00600.2006
   Schneider D, 2015, PLACENTA, V36, P552, DOI 10.1016/j.placenta.2015.02.003
   Schwarz JM, 2015, J CLIN ENDOCR METAB, V100, P2434, DOI 10.1210/jc.2014-3678
   Scifres CM, 2009, J PHYSIOL-LONDON, V587, P3453, DOI 10.1113/jphysiol.2009.173252
   Spencer RN, 2014, PRENATAL DIAG, V34, P677, DOI 10.1002/pd.4401
   Tappy L, 2010, PHYSIOL REV, V90, P23, DOI 10.1152/physrev.00019.2009
   Vickers MH, 2011, ENDOCRINOLOGY, V152, P1378, DOI 10.1210/en.2010-1093
   Zou M, 2012, NUTR RES, V32, P588, DOI 10.1016/j.nutres.2012.06.012
NR 53
TC 39
Z9 41
U1 2
U2 18
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 29
PY 2016
VL 6
AR 25091
DI 10.1038/srep25091
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DK8QE
UT WOS:000375192100001
PM 27125896
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cheung, O
   Sanyal, AJ
AF Cheung, Onpan
   Sanyal, Arun J.
TI Recent advances in nonalcoholic fatty liver disease
SO CURRENT OPINION IN GASTROENTEROLOGY
LA English
DT Review
DE de-novo lipogenesis; insulin resistance; metabolic syndrome;
   nonalcoholic steatohepatitis; oxidative stress
ID INSULIN-RESISTANCE; TRANSIENT ELASTOGRAPHY; HEPATIC STEATOSIS; RAT
   MODEL; GENE POLYMORPHISMS; METABOLIC SYNDROME; BARIATRIC SURGERY;
   PHYSICAL-ACTIVITY; ADIPOSE-TISSUE; X-RECEPTOR
AB Purpose of review
   This review focuses on recent advances in the study of the epidemiology, pathogenesis, natural history and treatment of nonalcoholic fatty liver disease (NAFLD).
   Recent findings
   Study of hepatic lipid metabolism with respect to the contribution of de-novo lipogenesis to hepatic steatosis and insulin resistance and the dysregulation of cellular adaptive response to stress, that is, the unfolded protein response has added to our current understanding of NAFLD. microRNA has recently emerged and has been shown to be differentially expressed in patients with nonalcoholic steatohepatitis. Its mechanism of action remains to be further explored. There is no proven pharmacotherapy for the treatment of NAFLD. Lifestyle intervention to achieve weight loss and increase exercise is persistently associated with improved liver histology. The diagnostic utility of noninvasive markers and imaging modalities in assessing fibrosis remains to be elucidated.
   Summary
   The underlying mechanism and pathogenesis of NAFLD remain elusive. Although research effort has advanced the understanding of the natural history, pathogenesis and management of the disease, there is no proven therapy for this medical condition. At present, treatment concentrates on managing underlying metabolic risk factors.
C1 [Cheung, Onpan; Sanyal, Arun J.] Virginia Commonwealth Univ, Med Ctr, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, Richmond, VA USA.
C3 Virginia Commonwealth University
RP Sanyal, AJ (corresponding author), MCV Box 980341, Richmond, VA 23298 USA.
EM ajsanyal@hsc.vcu.edu
FU National Institutes of Health [K24 DK 02755-07]
FX The work was supported in part by a grant from the National Institutes
   of Health to Dr A.J.S. K24 DK 02755-07.
CR Adams LA, 2008, J GASTROEN HEPATOL, V23, P1089, DOI 10.1111/j.1440-1746.2008.05451.x
   Aithal GP, 2008, GASTROENTEROLOGY, V135, P1176, DOI 10.1053/j.gastro.2008.06.047
   Barker KB, 2006, AM J GASTROENTEROL, V101, P368, DOI 10.1111/j.1572-0241.2006.00419.x
   Baumgardner JN, 2008, J NUTR, V138, P1872, DOI 10.1093/jn/138.10.1872
   Bellentani S, 2008, J HEPATOL, V48, pS338, DOI 10.1016/j.jhep.2008.05.003
   Bridle KR, 2006, J LAB CLIN MED, V147, P234, DOI 10.1016/j.lab.2005.12.009
   Browning JD, 2004, HEPATOLOGY, V40, P1387, DOI 10.1002/hep.20466
   Bruce CR, 2004, AM J PHYSIOL-ENDOC M, V287, pE616, DOI 10.1152/ajpendo.00150.2004
   Bruno RS, 2008, J NUTR, V138, P323, DOI 10.1093/jn/138.2.323
   Bugianesi E, 2005, DIABETOLOGIA, V48, P634, DOI 10.1007/s00125-005-1682-x
   Campos GM, 2008, HEPATOLOGY, V47, P1916, DOI 10.1002/hep.22241
   Canbakan B, 2008, ANN HEPATOL, V7, P249, DOI 10.1016/S1665-2681(19)31856-3
   Charlton M, 2008, HEPATOLOGY, V47, P484, DOI 10.1002/hep.22063
   Chen W, 2008, BASIC CLIN PHARMACOL, V103, P240, DOI 10.1111/j.1742-7843.2008.00268.x
   Cheung O, 2007, HEPATOLOGY, V46, P1091, DOI 10.1002/hep.21803
   Cheung O, 2008, HEPATOLOGY, V48, P1810, DOI 10.1002/hep.22569
   Crescenzo R, 2008, OBESITY, V16, P958, DOI 10.1038/oby.2008.10
   de Andrade AR, 2008, ANN HEPATOL, V7, P364
   Diab DL, 2008, CLIN GASTROENTEROL H, V6, P1249, DOI 10.1016/j.cgh.2008.07.016
   Esau C, 2006, CELL METAB, V3, P87, DOI 10.1016/j.cmet.2006.01.005
   Fallo F, 2008, J HYPERTENS, V26, P2191, DOI 10.1097/HJH.0b013e32830dfe4b
   Ferrante AW, 2007, J INTERN MED, V262, P408, DOI 10.1111/j.1365-2796.2007.01852.x
   Fracanzani AL, 2008, HEPATOLOGY, V48, P792, DOI 10.1002/hep.22429
   Fracanzani AL, 2008, AM J MED, V121, P72, DOI 10.1016/j.amjmed.2007.08.041
   Friedrich-Rust M, 2008, GASTROENTEROLOGY, V134, P960, DOI 10.1053/j.gastro.2008.01.034
   Furuya CK, 2007, J GASTROEN HEPATOL, V22, P510, DOI 10.1111/j.1440-1746.2007.04833.x
   Gabbi C, 2008, J CLIN GASTROENTEROL, V42, P107, DOI 10.1097/01.mcg.0000225583.32588.5e
   Green A, 2004, DIABETES, V53, P74, DOI 10.2337/diabetes.53.1.74
   Guzman G, 2008, ARCH PATHOL LAB MED, V132, P1761, DOI 10.1043/1543-2165-132.11.1761
   Harrison SA, 2009, HEPATOLOGY, V49, P80, DOI 10.1002/hep.22575
   Herruzo JAS, 2006, REV ESP ENFERM DIG, V98, P844
   Hirasaka K, 2007, DIABETES, V56, P2511, DOI 10.2337/db06-1768
   Hotamisligil GS, 1996, SCIENCE, V271, P665, DOI 10.1126/science.271.5249.665
   Hyogo H, 2008, METABOLISM, V57, P1711, DOI 10.1016/j.metabol.2008.07.030
   Ikejima K, 2002, GASTROENTEROLOGY, V122, P1399, DOI 10.1053/gast.2002.32995
   Jopling CL, 2006, COLD SPRING HARB SYM, V71, P369, DOI 10.1101/sqb.2006.71.022
   KAYADIBI H, 2008, DIG DIS SCI
   Kong B, 2009, J PHARMACOL EXP THER, V328, P116, DOI 10.1124/jpet.108.144600
   Krasnoff JB, 2008, HEPATOLOGY, V47, P1158, DOI 10.1002/hep.22137
   Liu XL, 2007, OBES SURG, V17, P486, DOI 10.1007/s11695-007-9086-2
   Loomba R., 2008, ALIMENT PHARM THER
   Malhi H, 2006, J BIOL CHEM, V281, P12093, DOI 10.1074/jbc.M510660200
   Marchesini G, 2001, DIABETES, V50, P1844, DOI 10.2337/diabetes.50.8.1844
   Mattar SG, 2005, ANN SURG, V242, P610, DOI 10.1097/01.sla.0000179652.07502.3f
   Merat S, 2008, DIGEST DIS SCI, V53, P2246, DOI 10.1007/s10620-007-0109-6
   Meymeh RH, 2007, CAN MED ASSOC J, V177, P723, DOI 10.1503/cmaj.071177
   MICALLEF MA, 2008, ATHEROSCLEROSIS
   Mishra P, 2008, LIVER INT, V28, P1080, DOI 10.1111/j.1478-3231.2008.01822.x
   Mofrad P, 2003, HEPATOLOGY, V37, P1286, DOI 10.1053/jhep.2003.50229
   Musso G, 2008, HEPATOLOGY, V47, P1167, DOI 10.1002/hep.22142
   Myhre AE, 2008, SHOCK, V29, P468, DOI 10.1097/SHK.0b013e31815073cb
   Nahon P, 2008, J HEPATOL, V49, P1062, DOI 10.1016/j.jhep.2008.08.011
   Nakagawa T, 2008, CLIN CHIM ACTA, V398, P34, DOI 10.1016/j.cca.2008.08.004
   NAR A, 2008, ACTA DIABETOL
   Naveau S, 2009, HEPATOLOGY, V49, P97, DOI 10.1002/hep.22576
   Nissen SE, 2007, NEW ENGL J MED, V356, P2457, DOI 10.1056/NEJMoa072761
   Nobili V, 2008, CLIN THER, V30, P1168, DOI 10.1016/j.clinthera.2008.06.012
   Nomiyama T, 2007, J CLIN INVEST, V117, P2877, DOI 10.1172/JCI31986
   Osei-Hyiaman D, 2005, J CLIN INVEST, V115, P1298, DOI 10.1172/JCI200523057
   Perseghin G, 2008, HEPATOLOGY, V47, P51, DOI 10.1002/hep.21983
   Puri P, 2008, GASTROENTEROLOGY, V134, P568, DOI 10.1053/j.gastro.2007.10.039
   Puri P, 2007, HEPATOLOGY, V46, P1081, DOI 10.1002/hep.21763
   Pusl T, 2008, BIOCHEM BIOPH RES CO, V371, P441, DOI 10.1016/j.bbrc.2008.04.113
   Qin XM, 2008, HEPATOLOGY, V48, P432, DOI 10.1002/hep.22334
   Ratziu V, 2007, ALIMENT PHARM THER, V25, P207, DOI 10.1111/j.1365-2036.2006.03182.x
   Ratziu V, 2008, GASTROENTEROLOGY, V135, P100, DOI 10.1053/j.gastro.2008.03.078
   Reid BN, 2008, J BIOL CHEM, V283, P13087, DOI 10.1074/jbc.M800533200
   RICCARDI L, 2008, AM J PHYSL IN PRESS
   Sanyal AJ, 2005, NAT CLIN PRACT GASTR, V2, P46, DOI 10.1038/ncpgasthep0084
   Sazci A, 2008, CELL BIOCHEM FUNCT, V26, P291, DOI 10.1002/cbf.1424
   Schindhelm RK, 2007, ATHEROSCLEROSIS, V191, P391, DOI 10.1016/j.atherosclerosis.2006.04.006
   Schwimmer JB, 2008, CIRCULATION, V118, P277, DOI 10.1161/CIRCULATIONAHA.107.739920
   Serrano A, 2008, NEUROPHARMACOLOGY, V54, P226, DOI 10.1016/j.neuropharm.2007.03.007
   Siegmund SV, 2005, HEPATOLOGY, V41, P1085, DOI 10.1002/hep.20667
   Song HR, 2008, AM J CLIN NUTR, V88, P16, DOI 10.1093/ajcn/88.1.16
   SOOKOIAN S, 2008, CLIN BIOCH
   SOOKOIAN S, 2008, J NUTR BIOCH
   SUNG KC, 2008, ATHEROSCLER IN PRESS
   Takamura T, 2007, INTERNAL MED, V46, P579, DOI 10.2169/internalmedicine.46.6374
   Tanaka N, 2008, J CLIN GASTROENTEROL, V42, P413, DOI 10.1097/MCG.0b013e31815591aa
   Tornita K, 2008, J MAGN RESON IMAGING, V28, P1444, DOI 10.1002/jmri.21596
   Ueda Y, 2008, NUTR RES, V28, P239, DOI 10.1016/j.nutres.2008.02.005
   Uno M, 2008, HEPATOLOGY, V48, P109, DOI 10.1002/hep.22338
   Villanova N, 2005, HEPATOLOGY, V42, P473, DOI 10.1002/hep.20781
   Völzke H, 2005, WORLD J GASTROENTERO, V11, P1848
   Wang HN, 2008, WORLD J GASTROENTERO, V14, P7240, DOI 10.3748/wjg.14.7240
   Werman A, 1997, J BIOL CHEM, V272, P20230, DOI 10.1074/jbc.272.32.20230
   Wieckowska A, 2008, AM J GASTROENTEROL, V103, P1372, DOI 10.1111/j.1572-0241.2007.01774.x
   Wieckowska A, 2006, HEPATOLOGY, V44, P27, DOI 10.1002/hep.21223
   Wong GLH, 2008, CLIN GASTROENTEROL H, V6, P1027, DOI 10.1016/j.cgh.2008.02.038
   WONG VW, 2008, ALIMENT PHA IN PRESS
   Wortham M, 2008, DIGEST DIS SCI, V53, P2761, DOI 10.1007/s10620-007-0193-7
   Wouters K, 2008, HEPATOLOGY, V48, P474, DOI 10.1002/hep.22363
   Wu XD, 2008, HEPATOLOGY, V47, P1905, DOI 10.1002/hep.22239
   Yamaguchi K, 2008, HEPATOLOGY, V47, P625, DOI 10.1002/hep.21988
   Yin M, 2007, CLIN GASTROENTEROL H, V5, P1207, DOI 10.1016/j.cgh.2007.06.012
   Yoneda M, 2008, BMC GASTROENTEROL, V8, DOI 10.1186/1471-230X-8-53
   Yoneda M, 2008, BMC GASTROENTEROL, V8, DOI 10.1186/1471-230X-8-27
   Younossi ZM, 2008, OBES SURG, V18, P1430, DOI 10.1007/s11695-008-9506-y
   Yu Jae-Hee, 2008, J Prev Med Public Health, V41, P407, DOI 10.3961/jpmph.2008.41.6.407
   Zelber-Sagi S, 2008, HEPATOLOGY, V48, P1791, DOI 10.1002/hep.22525
NR 101
TC 51
Z9 62
U1 0
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0267-1379
EI 1531-7056
J9 CURR OPIN GASTROEN
JI Curr. Opin. Gastroenterol.
PD MAY
PY 2009
VL 25
IS 3
BP 230
EP 237
DI 10.1097/MOG.0b013e3283294a18
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 443EH
UT WOS:000265892500010
PM 19396962
DA 2025-06-11
ER

PT J
AU Huang, Q
   Wang, DH
   Chen, SS
   Tang, L
   Ma, CY
AF Huang, Qi
   Wang, Denghong
   Chen, Shanshan
   Tang, Lei
   Ma, Chaoyang
TI Association of METS-IR index with depressive symptoms in US adults: A
   cross-sectional study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Insulin resistance; Cross-sectional study; NHANES; METS-IR
   index
ID ANTIDEPRESSANT MEDICATION USE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   TYPE-2; SENSITIVITY; RISK; PIOGLITAZONE; EPIDEMIOLOGY; GLUCOSE; PHQ-9
AB Background: An association between insulin resistance (IR) and depression has been identified in recent years. The purpose of this study was to examine the relationship between IR and depression in the general population. Methods: The population for this cross-sectional study consisted of adults participating in the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2018. Insulin sensitivity was assessed using the Metabolic Score for IR (METS-IR) index, while depression was evaluated using the Patient Health Questionnaire (PHQ)-9. Logistic regression analyses, subgroup analyses, and dose-response curves were conducted to assess the association between the METS-IR index and depression. Results: A total of 13,157 adults aged over 20 years were included in this study. After adjusting for potential confounders, it was observed that each unit increase in the METS-IR index was associated with a 1.1 percentage point increase in the prevalence of depression (OR = 1.011; 95 % CI: 1.008, 1.014). Patients in the 4th quartile of the METS-IR index had a higher likelihood of depression compared to those in the 1st quartile (OR = 1.386, 95 % CI: 1.239, 1.549). Stratified analyses demonstrated consistent results in all subgroups, except for men, patients under 40 years of age, and those with a history of cancer. Dose-response curves indicated a nonlinear relationship between the METS-IR index and the risk of depression, with an inflection point value of 32.443 according to threshold effect analysis. Conclusions: Our findings suggest that higher METS-IR scores are associated with an increased likelihood of experiencing depressive symptoms among U.S. adults.
C1 [Huang, Qi; Tang, Lei; Ma, Chaoyang] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Rehabil, 26 Shengli St, Wuhan 430014, Peoples R China.
   [Wang, Denghong] Jianghan Univ, Wuhan Hosp 6, Dept Rehabil Med, Affiliated Hosp, Wuhan 430000, Hubei, Peoples R China.
   [Chen, Shanshan] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Key Lab Mol Diag Hubei Prov, Wuhan 430014, Peoples R China.
C3 Huazhong University of Science & Technology; Jianghan University;
   Huazhong University of Science & Technology
RP Tang, L; Ma, CY (corresponding author), Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Rehabil, 26 Shengli St, Wuhan 430014, Peoples R China.
EM tanglei125716@126.com; chaoyangm2023@163.com
RI Chen, Shanshan/AAO-2763-2020; tang, lei/JCO-4117-2023
FU Key Discipline Fund of Wuhan Central Hospital, Huazhong University of
   Science and Technology [2021XK040]
FX This work was supported by the Key Discipline Fund of Wuhan Central
   Hospital, Huazhong University of Science and Technology (No. 2021XK040)
   .
CR ADAA, 1979, Anxiety and Depression Association of America.
   Adriaanse MC, 2006, DIABETOLOGIA, V49, P2874, DOI 10.1007/s00125-006-0500-4
   Brieler JA, 2016, FAM PRACT, V33, P30, DOI 10.1093/fampra/cmv100
   Brown AE, 2016, CURR CARDIOL REP, V18, DOI 10.1007/s11886-016-0755-4
   Byers AL, 2011, NAT REV NEUROL, V7, P323, DOI 10.1038/nrneurol.2011.60
   Carney RM, 2017, NAT REV CARDIOL, V14, DOI 10.1038/nrcardio.2016.181
   Chen WQ, 2022, TRENDS NEUROSCI, V45, P384, DOI 10.1016/j.tins.2022.03.001
   Derry HM, 2015, CURR PSYCHIAT REP, V17, DOI 10.1007/s11920-015-0618-5
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Hidese S, 2018, J PSYCHIATR RES, V102, P23, DOI 10.1016/j.jpsychires.2018.02.009
   Hirschtritt ME, 2017, JAMA-J AM MED ASSOC, V318, P745, DOI 10.1001/jama.2017.9820
   Kashani L, 2013, PSYCHONEUROENDOCRINO, V38, P767, DOI 10.1016/j.psyneuen.2012.08.010
   Kemp DE, 2014, CNS DRUGS, V28, P571, DOI 10.1007/s40263-014-0158-2
   Kessler RC, 2003, J AFFECT DISORDERS, V74, P5, DOI 10.1016/S0165-0327(02)00426-3
   KESSLER RC, 1993, J AFFECT DISORDERS, V29, P85, DOI 10.1016/0165-0327(93)90026-G
   Khambaty T, 2014, PSYCHOSOM MED, V76, P363, DOI 10.1097/PSY.0000000000000063
   Khoza S, 2012, EUR J CLIN PHARMACOL, V68, P1295, DOI 10.1007/s00228-011-1168-3
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Lee JH, 2017, J AFFECT DISORDERS, V208, P553, DOI 10.1016/j.jad.2016.10.027
   Mathers CD, 2006, PLOS MED, V3, DOI 10.1371/journal.pmed.0030442
   Maury E, 2010, MOL CELL ENDOCRINOL, V314, P1, DOI 10.1016/j.mce.2009.07.031
   McGown C, 2014, CLIN LIVER DIS, V18, P41, DOI 10.1016/j.cld.2013.09.012
   McIntyre RS, 2006, EXPERT OPIN DRUG SAF, V5, P157, DOI 10.1517/14740338.5.1.157
   MIROWSKY J, 1992, J HEALTH SOC BEHAV, V33, P187, DOI 10.2307/2137349
   Moriarty AS, 2015, GEN HOSP PSYCHIAT, V37, P567, DOI 10.1016/j.genhosppsych.2015.06.012
   Musselman DL, 2003, BIOL PSYCHIAT, V54, P317, DOI 10.1016/S0006-3223(03)00569-9
   Nagle CA, 2009, J LIPID RES, V50, pS74, DOI 10.1194/jlr.R800053-JLR200
   Nock MK, 2010, MOL PSYCHIATR, V15, P868, DOI 10.1038/mp.2009.29
   Otte C, 2016, NAT REV DIS PRIMERS, V2, DOI 10.1038/nrdp.2016.65
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Parhofer KG, 2015, DIABETES METAB J, V39, P353
   Park SY, 2021, DIABETES METAB J, V45, P641, DOI 10.4093/dmj.2021.0220
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Pyykkönen AJ, 2011, DIABETES CARE, V34, P2545, DOI 10.2337/dc11-0107
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Shelton RC, 2010, PROG NEUROBIOL, V91, P275, DOI 10.1016/j.pneurobio.2010.04.004
   Soares CN, 2008, J PSYCHIATR NEUROSCI, V33, P331
   van Rossum EFC, 2002, DIABETES, V51, P3128, DOI 10.2337/diabetes.51.10.3128
   Vijan S, 2015, ANN INTERN MED, V162, DOI 10.7326/AITC201503030
   Wakefield CE, 2015, LANCET PSYCHIAT, V2, P635, DOI 10.1016/S2215-0366(15)00168-6
   Watson KT, 2021, JAMA PSYCHIAT, V78, P439, DOI 10.1001/jamapsychiatry.2020.3669
   Bello-Chavolla OY, 2018, EUR J ENDOCRINOL, V178, P533, DOI 10.1530/EJE-17-0883
NR 42
TC 10
Z9 10
U1 10
U2 24
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JUN 15
PY 2024
VL 355
BP 355
EP 362
DI 10.1016/j.jad.2024.03.129
EA APR 2024
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA RH9R3
UT WOS:001226896500001
PM 38554881
OA hybrid
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Tomas, E
   Stanojevic, V
   Habener, JF
AF Tomas, Eva
   Stanojevic, Violeta
   Habener, Joel F.
TI GLP-1-derived nonapeptide GLP-1(28-36)amide targets to mitochondria and
   suppresses glucose production and oxidative stress in isolated mouse
   hepatocytes
SO REGULATORY PEPTIDES
LA English
DT Article
DE Diabetes; Metabolic syndrome; Insulin resistance; Liver; NEP 24.11
ID GLUCAGON-LIKE PEPTIDE-1; GLP-1 9-36 AMIDE; NEUTRAL ENDOPEPTIDASE-24.11;
   INSULIN-RESISTANCE; METABOLITE; RECEPTOR; PROTEIN; DEGRADATION; IV
AB Background: Uncontrolled hepatic glucose production (gluconeogenesis), and glycogenolysis, is a major contributor to the fasting hyperglycemia associated with type 2 diabetes. Here we report the discovery of a C-terminal nonapeptide (FIAWLVKGRamide) derived from GLP-1 that suppresses glucose production and oxidative stress in isolated mouse hepatocytes. The nonapeptide, GLP-1(28-36)amide, was reported earlier to be a major product derived from the cleavage of GLP-1 by the endopeptidase NEP 24.11.
   Methods and results: Hepatocytes were isolated from the livers of normal and diet-induced obese mice. We find that the GLP-1(28-36)amide nonapeptide rapidly enters isolated mouse hepatocytes by GLP-1 receptor-independent mechanisms, and targets to mitochondria where it inhibits gluconeogenesis and oxidative stress.
   Conclusions: These findings suggest that GLP-1 not only acts on a cell surface G-protein coupled receptor activating kinase-regulated signaling pathways, but a small C-terminal peptide derived from GLP-1 also enters cells, targets mitochondria, and exerts insulin-like actions by modulating oxidative phosphorylation. GLP-1(28-36)amide, or a peptide mimetic derived there from, might prove to be a useful treatment for fasting hyperglycemia and metabolic syndrome in type 2 diabetes. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Tomas, Eva; Stanojevic, Violeta; Habener, Joel F.] Massachusetts Gen Hosp, Mol Endocrinol Lab, Boston, MA 02114 USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital
RP Habener, JF (corresponding author), Massachusetts Gen Hosp, Mol Endocrinol Lab, Boston, MA 02114 USA.
EM jhabener@partners.org
FU Merck Co.; Novo Nordisk
FX We thank Zhenghu Liu and Karen McManus for helpful comments and for help
   in the assays, and Robert Tyszkowski in the MGH PMB Microscopy Core for
   confocal imaging. Early phases of the studies were supported in part by
   a one-year Investigator Initiated Studies Program grant from Merck &
   Co.Later studies were supported in part by a Basic Science Grant from
   Novo Nordisk.
CR Abu-Hamdah R, 2009, J CLIN ENDOCR METAB, V94, P1843, DOI 10.1210/jc.2008-1296
   BALDWIN GS, 1994, P NATL ACAD SCI USA, V91, P7593, DOI 10.1073/pnas.91.16.7593
   Ban K, 2008, CIRCULATION, V117, P2340, DOI 10.1161/CIRCULATIONAHA.107.739938
   Ban K, 2010, ENDOCRINOLOGY, V151, P1520, DOI 10.1210/en.2009-1197
   BROWNLEE M, 2008, Patent No. 2008194483
   Brun C, 2006, FASEB J, V20, P732, DOI 10.1096/fj.05-4338fje
   Chatre L, 2009, J EXP BOT, V60, P741, DOI 10.1093/jxb/ern319
   Deacon CF, 2004, HORM METAB RES, V36, P761, DOI 10.1055/s-2004-826160
   Elahi D, 2008, OBESITY, V16, P1501, DOI 10.1038/oby.2008.229
   Flock G, 2007, DIABETES, V56, P3006, DOI 10.2337/db07-0697
   Grattagliano I, 2008, J NUTR BIOCHEM, V19, P491, DOI 10.1016/j.jnutbio.2007.06.011
   Green BD, 2008, ARCH BIOCHEM BIOPHYS, V478, P136, DOI 10.1016/j.abb.2008.08.001
   Haas JT, 2009, CURR OPIN LIPIDOL, V20, P206, DOI 10.1097/MOL.0b013e32832b2024
   Hansen L, 1999, ENDOCRINOLOGY, V140, P5356, DOI 10.1210/en.140.11.5356
   Hashimoto T, 1996, J BIOCHEM-TOKYO, V119, P1196
   Hirst J, 2010, BIOCHEM J, V425, P327, DOI 10.1042/BJ20091382
   HUPESODMANN K, 1995, REGUL PEPTIDES, V58, P149, DOI 10.1016/0167-0115(95)00063-H
   Kieffer TJ, 1999, ENDOCR REV, V20, P876, DOI 10.1210/er.20.6.876
   LEMIRE BD, 1989, J BIOL CHEM, V264, P20206
   Liu HY, 2007, J BIOL CHEM, V282, P14205, DOI 10.1074/jbc.M609701200
   Lovshin JA, 2009, NAT REV ENDOCRINOL, V5, P262, DOI 10.1038/nrendo.2009.48
   Meier JJ, 2006, AM J PHYSIOL-ENDOC M, V290, pE1118, DOI 10.1152/ajpendo.00576.2005
   Nikolaidis LA, 2005, AM J PHYSIOL-HEART C, V289, pH2401, DOI 10.1152/ajpheart.00347.2005
   Ott M, 2007, APOPTOSIS, V12, P913, DOI 10.1007/s10495-007-0756-2
   Plamboeck A, 2005, DIABETOLOGIA, V48, P1882, DOI 10.1007/s00125-005-1847-7
   Randle PJ, 1998, DIABETES METAB REV, V14, P263, DOI 10.1002/(SICI)1099-0895(199812)14:4<263::AID-DMR233>3.0.CO;2-C
   Rodrigue-Way A, 2007, ENDOCRINOLOGY, V148, P1009, DOI 10.1210/en.2006-0975
   Simonsen L, 2009, HORM METAB RES, V41, P851, DOI 10.1055/s-0029-1225609
   Sonne DP, 2008, REGUL PEPTIDES, V146, P243, DOI 10.1016/j.regpep.2007.10.001
   Stein LL, 2009, ADV THER, V26, P893, DOI 10.1007/s12325-009-0072-z
   Szeto HH, 2006, AAPS J, V8, pE277, DOI 10.1007/BF02854898
   Tomas E, 2011, DIABETES OBES METAB, V13, P26, DOI 10.1111/j.1463-1326.2010.01316.x
   Tomas E, 2010, HORM METAB RES, V42, P657, DOI 10.1055/s-0030-1253421
   Tomas E, 2010, TRENDS ENDOCRIN MET, V21, P59, DOI 10.1016/j.tem.2009.11.007
   Yamada H, 2004, FEBS LETT, V578, P331, DOI 10.1016/j.febslet.2004.11.017
   ZHAO K, 2007, J BIOL CHEM, V279, P34682
NR 36
TC 84
Z9 98
U1 0
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0167-0115
EI 1873-1686
J9 REGUL PEPTIDES
JI Regul. Pept.
PD APR 11
PY 2011
VL 167
IS 2-3
BP 177
EP 184
DI 10.1016/j.regpep.2011.01.003
PG 8
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 755JT
UT WOS:000289927000004
PM 21256872
DA 2025-06-11
ER

PT J
AU Sevilla-González, MD
   Quintana-Mendoza, BM
   Aguilar-Salinas, CA
AF del Rocio Sevilla-Gonzalez, Magdalena
   Macale Quintana-Mendoza, Brenda
   Alberto Aguilar-Salinas, Carlos
TI Interaction Between Depression, Obesity, and Type 2 Diabetes: A Complex
   Picture
SO ARCHIVES OF MEDICAL RESEARCH
LA English
DT Review
DE Depression; Obesity; Type 2 diabetes; Body weight
ID BODY-MASS INDEX; DIETARY PATTERNS; GLYCEMIC CONTROL;
   PSYCHIATRIC-DISORDERS; METABOLIC SYNDROME; BARIATRIC SURGERY;
   PHYSICAL-ACTIVITY; WEIGHT-LOSS; RISK-FACTOR; SYMPTOMS
AB Depression plays an important role in the pathogenesis and treatment of obesity and type 2 diabetes (T2D). However, its relevance is frequently unrecognized by clinicians and researchers. The purpose of this review is to present a critical analysis of the evidence linking depression and metabolic disorders and to highlight the practical implications of this complex relationship. Evidence obtained from epidemiological, basic, clinical and controlled studies demonstrate that the association goes beyond a random phenomenon. Epidemiological studies have rendered controversial results due to the lack of control of the confounding variables and the bidirectional relationship that exists between the outcomes and the conditions that modulate the association (i.e. socioeconomic status). Animal and human studies have been useful to define the anatomic substrates and physiologic processes that participate in the association, but, the evidence is preliminary in many areas (i.e gene x environmental interactions). Controlled studies have shown the strong impact that treatment of depression has on body weight and the large effect that has the correction of excess body weight on the depression-related symptoms. Practical implications of the depression-obesity duet include the training of the health providers to assess and treat these conditions in a concomitant manner, the need for translational medicine projects and the application the systems biology approach to fill the existing gaps of knowledge. (C) 2018 IMSS. Published by Elsevier Inc.
C1 Inst Nacl Nutr Salvador Zubiran, Unidad Invest Enfermedades Metab, Ciudad De Mexico, Mexico.
   Inst Tecnol & Estud Super Monterrey Tec Salud, Ciudad De Mexico, Mexico.
C3 Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico; Tecnologico de Monterrey
RP Aguilar-Salinas, CA (corresponding author), Vasco de Quiroga 15, Ciudad De Mexico 14080, Mexico.
EM caguilarsalinas@yahoo.com
RI Salinas, Carlos/HSA-8329-2023
CR Afari N, 2010, DEPRESS ANXIETY, V27, P799, DOI 10.1002/da.20704
   Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   [Anonymous], REV COLOMBIANA ENDOC
   [Anonymous], ETHN HLTH
   [Anonymous], 2017, OB OV FACTSH
   [Anonymous], ENCUENSTA NAC SALUD
   Arendt DH, 2013, BEHAV NEUROSCI, V127, P86, DOI 10.1037/a0031442
   ASHLEY DVM, 1985, AM J CLIN NUTR, V42, P1240, DOI 10.1093/ajcn/42.6.1240
   Becker M, 2016, CURR PSYCHIAT REP, V18, DOI 10.1007/s11920-016-0664-7
   Cai N, 2015, NATURE, V523, P588, DOI 10.1038/nature14659
   Caspi A, 2003, SCIENCE, V301, P386, DOI 10.1126/science.1083968
   Chang LY, 2017, INT J OBESITY, V41, P1510, DOI 10.1038/ijo.2017.111
   Chang SH, 2014, JAMA SURG, V149, P275, DOI 10.1001/jamasurg.2013.3654
   Chieffi S, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00357
   CHROUSOS GP, 1995, NEW ENGL J MED, V332, P1351, DOI 10.1056/NEJM199505183322008
   Cindik N, 2005, ACTA PAEDIATR, V94, P1732, DOI 10.1080/08035250500277101
   Colunga-Rodriguez C., 2005, Rev. Salud publica, V10, P137
   Crispín-Trebejo B, 2015, ASIA-PAC PSYCHIAT, V7, P419, DOI 10.1111/appy.12190
   Darville MI, 1998, DIABETOLOGIA, V41, P1101, DOI 10.1007/s001250051036
   Duman RS, 2006, BIOL PSYCHIAT, V59, P1116, DOI 10.1016/j.biopsych.2006.02.013
   Fava M, 2000, J CLIN PSYCHIAT, V61, P37
   Frisard C, 2015, BMC ENDOCR DISORD, V15, DOI 10.1186/s12902-015-0049-7
   Fuemmeler BF, 2008, OBESITY, V16, P348, DOI 10.1038/oby.2007.65
   Fung TT, 2004, ARCH INTERN MED, V164, P2235, DOI 10.1001/archinte.164.20.2235
   Gallegos-Carrillo K, 2013, HEALTH PSYCHOL, V32, P609, DOI 10.1037/a0029276
   Garduno-Espinosa J, 1998, REV INVEST CLIN, V50, P287
   Geschwind DH, 2015, SCIENCE, V349, P1489, DOI 10.1126/science.aaa8954
   Golden SH, 2008, JAMA-J AM MED ASSOC, V299, P2751, DOI 10.1001/jama.299.23.2751
   Gratas-Delamarche A, 2014, FREE RADICAL RES, V48, P93, DOI 10.3109/10715762.2013.847528
   Hosseinzadeh M, 2016, PUBLIC HEALTH NUTR, V19, P204, DOI 10.1017/S136898001500172X
   Jain AK, 2002, OBES RES, V10, P1049, DOI 10.1038/oby.2002.142
   Janssen EPCJ, 2016, J AM GERIATR SOC, V64, pE201, DOI 10.1111/jgs.14388
   Jantaratnotai N, 2017, OBES RES CLIN PRACT, V11, P1, DOI 10.1016/j.orcp.2016.07.003
   Jensen MD, 2014, OBESITY, V22, pS5, DOI 10.1002/oby.20821
   Kendzor DE, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-176
   Kim C, 2002, DIABETES CARE, V25, P1862, DOI 10.2337/diacare.25.10.1862
   Kim YK, 2007, PROG NEURO-PSYCHOPH, V31, P1044, DOI 10.1016/j.pnpbp.2007.03.004
   Knol MJ, 2006, DIABETOLOGIA, V49, P837, DOI 10.1007/s00125-006-0159-x
   Ko A, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4983
   Kurhe Y, 2015, ASIAN J PSYCHIATR, V17, P3, DOI 10.1016/j.ajp.2015.07.007
   Kyrou I, 2009, CURR OPIN PHARMACOL, V9, P787, DOI 10.1016/j.coph.2009.08.007
   Lai JS, 2014, AM J CLIN NUTR, V99, P181, DOI 10.3945/ajcn.113.069880
   Lasserre AM, 2014, JAMA PSYCHIAT, V71, P880, DOI 10.1001/jamapsychiatry.2014.411
   Lee JH, 2017, EUR PSYCHIAT, V45, P72, DOI 10.1016/j.eurpsy.2017.05.025
   Lindsay AC, 2017, INT J ENV RES PUB HE, V14, DOI 10.3390/ijerph14080869
   De la Roca-Chiapas JM, 2013, REV INVEST CLIN, V65, P209
   Medina-Mora ME, 2003, SALUD MENT, V26, P1
   Mihrshahi S, 2015, EUR J CLIN NUTR, V69, P585, DOI 10.1038/ejcn.2014.222
   Monserud MA, 2015, RES AGING, V37, P856, DOI 10.1177/0164027514568104
   Neri C, 2018, GYNECOL ENDOCRINOL, V34, P28, DOI 10.1080/09513590.2017.1342792
   Ohmori Y, 2017, ASIA PAC J CLIN NUTR, V26, P130, DOI 10.6133/apjcn.112015.01
   Olvera RL, 2015, J CLIN PSYCHIAT, V76, pE1300, DOI 10.4088/JCP.14m09118
   Owens M, 2016, DEV PSYCHOPATHOL, V28, P385, DOI 10.1017/S0954579415000462
   Pereira-Miranda E, 2017, J AM COLL NUTR, V36, P223, DOI 10.1080/07315724.2016.1261053
   Quteineh L, 2016, J AFFECT DISORDERS, V198, P43, DOI 10.1016/j.jad.2016.03.031
   Rajan TM, 2017, J POSTGRAD MED, V63, P182, DOI 10.4103/jpgm.JPGM_712_16
   Rienks J, 2013, EUR J CLIN NUTR, V67, P75, DOI 10.1038/ejcn.2012.193
   Rios M, 2011, NEUROPSYCHOPHARMACOL, V36, P368, DOI 10.1038/npp.2010.139
   Rivera M, 2017, BRIT J PSYCHIAT, V211, P70, DOI 10.1192/bjp.bp.116.183475
   Ruusunen A, 2012, DIABETIC MED, V29, pE126, DOI 10.1111/j.1464-5491.2012.03602.x
   Ryan DH, 2017, CURR OBES REP, V6, P187, DOI 10.1007/s13679-017-0262-y
   Saucedo R, 2012, GYNECOL OBSTET INVES, V73, P58, DOI 10.1159/000331652
   Saydah SH, 2003, DIABETES-METAB RES, V19, P202, DOI 10.1002/dmrr.353
   Scherrer JF, 2011, DIABETES CARE, V34, P1729, DOI 10.2337/dc11-0031
   Schulze MB, 2005, AM J CLIN NUTR, V82, P675, DOI 10.1093/ajcn/82.3.675
   Serretti A, 2010, J CLIN PSYCHIAT, V71, P1259, DOI 10.4088/JCP.09r05346blu
   Shah ZC, 2005, ETHNIC DIS, V15, P685
   Shi ZM, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2017-016224
   Sieu N, 2011, GEN HOSP PSYCHIAT, V33, P429, DOI 10.1016/j.genhosppsych.2011.05.021
   Simon GE, 2006, ARCH GEN PSYCHIAT, V63, P824, DOI 10.1001/archpsyc.63.7.824
   Slone LB, 2006, DEPRESS ANXIETY, V23, P158, DOI 10.1002/da.20137
   Smith Kerri, 2014, Nature, V515, P181, DOI 10.1038/515180a
   Sookoian S, 2007, OBESITY, V15, P271, DOI 10.1038/oby.2007.519
   STUNKARD AJ, 1986, JAMA-J AM MED ASSOC, V256, P51, DOI 10.1001/jama.256.1.51
   Stunkard AJ, 2003, BIOL PSYCHIAT, V54, P330, DOI 10.1016/S0006-3223(03)00608-5
   Surwit RS, 2002, DIABETES CARE, V25, P30, DOI 10.2337/diacare.25.1.30
   Taylor VH, 2017, CAN J DIABETES, V41, P448, DOI 10.1016/j.jcjd.2017.04.004
   Terracciano A, 2010, BIOL PSYCHIAT, V68, P811, DOI 10.1016/j.biopsych.2010.06.030
   Tovilla-Zárate C, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036887
   van Dooren FEP, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057058
   Vancampfort D, 2015, DEPRESS ANXIETY, V32, P763, DOI 10.1002/da.22387
   Vos T, 2017, LANCET, V390, P1211, DOI 10.1016/S0140-6736(17)32154-2
   Wagner J, 2009, DIABETES RES CLIN PR, V86, P96, DOI 10.1016/j.diabres.2009.06.024
   Whitaker KM, 2014, NUTR RES, V34, P294, DOI 10.1016/j.nutres.2014.01.007
   Williams LH, 2010, AM J MED, V123, P748, DOI 10.1016/j.amjmed.2010.01.023
   Winwood-Smith HS, 2017, AM J PHYSIOL-REG I, V313, pR347, DOI 10.1152/ajpregu.00067.2017
   Yu M, 2015, CAN J DIABETES, V39, P266, DOI 10.1016/j.jcjd.2014.11.006
   Zhong WJ, 2010, DEPRESS ANXIETY, V27, P846, DOI 10.1002/da.20666
NR 88
TC 29
Z9 30
U1 1
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0188-4409
EI 1873-5487
J9 ARCH MED RES
JI Arch. Med. Res.
PD OCT
PY 2017
VL 48
IS 7
BP 582
EP 591
DI 10.1016/j.arcmed.2018.02.004
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA GC9ZW
UT WOS:000430158500002
PM 29478673
DA 2025-06-11
ER

PT J
AU Sánchez-Carro, Y
   de la Torre-Luque, A
   Leal-Leturia, I
   Salvat-Pujol, N
   Massaneda, C
   de Arriba-Arnau, A
   Urretavizcaya, M
   Pérez-Solà, V
   Toll, A
   Martínez-Ruiz, A
   Ferreirós-Martínez, R
   Pérez, S
   Sastre, J
   Alvarez, P
   Soria, V
   López-García, P
AF Sanchez-Carro, Yolanda
   de la Torre-Luque, Alejandro
   Leal-Leturia, Itziar
   Salvat-Pujol, Neus
   Massaneda, Clara
   de Arriba-Arnau, Aida
   Urretavizcaya, Mikel
   Perez-Sola, Victor
   Toll, Alba
   Martinez-Ruiz, Antonio
   Ferreiros-Martinez, Raquel
   Perez, Salvador
   Sastre, Juan
   Alvarez, Pilar
   Soria, Virginia
   Lopez-Garcia, Pilar
TI Importance of immunometabolic markers for the classification of patients
   with major depressive disorder using machine learning
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Major depressive disorder; Inflammation; Oxidative stress; Metabolic
   syndrome; Lifestyle habits; Machine learning
ID NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; PHYSICAL-ACTIVITY;
   LIPID-PEROXIDATION; TREATMENT RESPONSE; MENTAL-ILLNESS; EXERCISE;
   GLUTATHIONE; SMOKING; LIFE
AB Background: Although there is scientific evidence of the presence of immunometabolic alterations in major depression, not all patients present them. Recent studies point to the association between an inflammatory phenotype and certain clinical symptoms in patients with depression. The objective of our study was to classify major depression disorder patients using supervised learning algo-rithms or machine learning, based on immunometabolic and oxidative stress biomarkers and lifestyle habits.Methods: Taking into account a series of inflammatory and oxidative stress biomarkers (C-reactive protein (CRP), tumor necrosis factor (TNF), 4-hydroxynonenal (HNE) and glutathione), metabolic risk markers (blood pressure, waist circumference and glucose, triglyceride and cholesterol levels) and lifestyle habits of the participants (physical activity, smoking and alcohol consumption), a study was carried out using machine learning in a sample of 171 participants, 91 patients with depression (71.42% women, mean age = 50.64) and 80 healthy subjects (67.50% women, mean age = 49.12).The algorithm used was the support vector machine, performing cross validation, by which the subdivision of the sample in training (70%) and test (30%) was carried out in order to estimate the precision of the model. The prediction of belonging to the patient group (MDD patients versus control subjects), melancholic type (melancholic versus non-melancholic patients) or resistant depression group (treatment-resistant versus non -treatment-resistant) was based on the importance of each of the immunometabolic and lifestyle variables.Results: With the application of the algorithm, controls versus patients, such as patients with melancholic symptoms versus non-melancholic symptoms, and resistant versus non-resistant symptoms in the test phase were optimally classified.The variables that showed greater importance, according to the results of the area under the ROC curve, for the discrimination between healthy subjects and patients with depression were current alcohol consumption (AUC = 0.62), TNF-alpha levels (AUC = 0.61), glutathione redox status (AUC = 0.60) and the performance of both moderate (AUC = 0.59) and vigorous physical exercise (AUC = 0.58). On the other hand, the most important variables for classifying melancholic patients in relation to lifestyle habits were past (AUC = 0.65) and current (AUC = 0.60) tobacco habit, as well as walking routinely (AUC = 0.59) and in relation to immunometabolic markers were the levels of CRP (AUC = 0.62) and glucose (AUC = 0.58).In the analysis of the importance of the variables for the classification of treatment-resistant patients versus non-resistant patients, the systolic blood pressure (SBP) variable was shown to be the most relevant (AUC = 0.67). Other immunometabolic variables were also among the most important such as TNF-alpha (AUC = 0.65) and waist circumference (AUC = 0.64). In this case, sex (AUC = 0.59) was also relevant along with alcohol (AUC = 0.58) and tobacco (AUC = 0.56) consumption.Conclusions: The results obtained in our study show that it is possible to predict the diagnosis of depression and its clinical typology from immunometabolic markers and lifestyle habits, using machine learning techniques. The use of this type of methodology could facilitate the identification of patients at risk of presenting depression and could be very useful for managing clinical heterogeneity.
C1 [Sanchez-Carro, Yolanda; Leal-Leturia, Itziar; Lopez-Garcia, Pilar] Univ Autonoma Madrid UAM, Dept Psychiat, Madrid, Spain.
   [Sanchez-Carro, Yolanda; Leal-Leturia, Itziar; Lopez-Garcia, Pilar] Inst Invest Sanitaria Princesa IIS IP, Dept Psychiat, Madrid, Spain.
   [Sanchez-Carro, Yolanda; de la Torre-Luque, Alejandro; Leal-Leturia, Itziar; Urretavizcaya, Mikel; Perez-Sola, Victor; Soria, Virginia; Lopez-Garcia, Pilar] Carlos III Hlth Inst, Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain.
   [de la Torre-Luque, Alejandro] Univ Complutense Madrid, Dept Legal Med Psychiat & Pathol, Madrid, Spain.
   [Salvat-Pujol, Neus; Massaneda, Clara; de Arriba-Arnau, Aida; Urretavizcaya, Mikel; Soria, Virginia] Bellvitge Univ Hosp, Bellvitge Biomed Res Inst IDIBELL, Dept Psychiat, Neurosci Grp,Psychiat & Mental Hlth, Barcelona, Spain.
   [Salvat-Pujol, Neus] Corp Sanitaria Parc Tauli, Dept Mental Hlth, Sabadell, Spain.
   [Urretavizcaya, Mikel; Soria, Virginia] Univ Barcelona UB, Sch Med, Dept Clin Sci, Barcelona, Spain.
   [Perez-Sola, Victor] Univ Pompeu Fabra UPF, Barcelona, Spain.
   [Perez-Sola, Victor; Toll, Alba] Hosp Del Mar, Inst Neuropsiquiatria & Addic, Psychiat Dept, IMIM Hosp Del Mar,Med Res Inst, Barcelona, Spain.
   [Martinez-Ruiz, Antonio] Hosp Univ Santa Cristina, Unidad Invest, Inst Invest Sanitaria Princesa IIS IP, Madrid, Spain.
   [Ferreiros-Martinez, Raquel] Hosp Univ Princesa, Serv Clin Anal, Inst Invest Sanitaria Princesa IIS IP, Madrid, Spain.
   [Perez, Salvador; Sastre, Juan] Univ Valencia, Fac Pharm, Dept Physiol, Valencia, Spain.
   [Alvarez, Pilar] IMIM Hosp Del Mar, Psychiat Dept, Inst Neuropsiquiatria & Addic, Ctr Forum,Med Res Inst, Barcelona, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBERSAM; Complutense
   University of Madrid; University of Barcelona; Institut d'Investigacio
   Biomedica de Bellvitge (IDIBELL); Bellvitge University Hospital;
   Autonomous University of Barcelona; Parc Tauli Hospital Universitari;
   University of Barcelona; Pompeu Fabra University; Hospital del Mar
   Research Institute; Hospital del Mar; Hospital de La Princesa;
   University of Valencia; Hospital del Mar Research Institute; Hospital
   del Mar
RP López-García, P (corresponding author), Carlos III Hlth Inst, Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain.; López-García, P (corresponding author), Univ Autonoma Madrid, Sch Med, Dept Psychiat, 4 Arzobispo Morcillo St, Madrid 28029, Spain.
RI SASTRE, JUAN/AAB-2344-2019; Sanchez Carro, Yolanda/AAC-9898-2022;
   Lopez-Garcia, Pilar/F-5934-2013; Pérez, Salvador/N-5943-2014; Pérez
   Sola, Víctor/KBA-2879-2024; Alvarez, Pilar/JAC-0258-2023; de la
   Torre-Luque, Alejandro/AAJ-3508-2020; Toll, Alba/O-1512-2015;
   Martinez-Ruiz, Antonio/A-5672-2009
OI Alvarez, Pilar/0000-0002-6648-3493; Sanchez,
   Yolanda/0000-0002-8644-9436; Toll, Alba/0000-0003-2399-5250; Perez Sola,
   Victor/0000-0002-5825-2337; Massaneda-Tuneu, Clara/0000-0003-4385-0518;
   Martinez-Ruiz, Antonio/0000-0001-5394-9824; Soria,
   Virginia/0000-0001-6412-6831
FU Carlos III Health Institute through the Ministry of Science, Innovation
   and Universities [PI15/00662, PI15/0039, PI15/00204, PI19/01040];
   European Regional Development Fund (ERDF) "A way to build Europe";
   CIBERSAM; Catalan Agency for the Management of University and Research
   Grants [AGAUR 2017 SGR 1247]; Biobank HUB-ICO-IDIBELL, integrated in the
   Spanish Biobank Network; Instituto de Salud Carlos III [PT17/0015/0024,
   INT21/00055]; Xarxa Bancs de Tumors de Catalunya - Pla Director
   d'Oncologia de Catalunya (XBTC); Universidad Autonoma de Madrid [FPI
   2016/17]
FX This study was supported in part by grants from the Carlos III Health
   Institute through the Ministry of Science, Innovation and Universities
   (PI15/00662, PI15/0039, PI15/00204, PI19/01040), co-funded by the
   European Regional Development Fund (ERDF) "A way to build Europe",
   CIBERSAM, and the Catalan Agency for the Management of University and
   Research Grants (AGAUR 2017 SGR 1247). We also thank CERCA
   Programme/Generalitat de Catalunya for institutional support. Work
   partially supported by Biobank HUB-ICO-IDIBELL, integrated in the
   Spanish Biobank Network and funded by Instituto de Salud Carlos III
   (PT17/0015/0024) and by Xarxa Bancs de Tumors de Catalunya sponsored by
   Pla Director d'Oncologia de Catalunya (XBTC). The funders had no role in
   the study design, data collection and analysis, decision to publish, or
   preparation of the manuscript. YSC work is supported by the FPI
   predoctoral grant (FPI 2016/17) from Universidad Autonoma de Madrid. VS
   received an Intensification of the Research Activity Grant from the
   Instituto de Salud Carlos III (INT21/00055) during 2022.
CR American Psychiatric Association, 2000, spectrum disorders using the current DSM-IV-TR diagnostic, V4th, DOI 10.1176/dsm10.1176/appi.books.9780890420249.dsm-iv-tr
   Anisman H, 1999, MOL PSYCHIATR, V4, P182, DOI 10.1038/sj.mp.4000436
   Beleites C, 2008, ANAL BIOANAL CHEM, V390, P1261, DOI 10.1007/s00216-007-1818-6
   Beurel E, 2020, NEURON, V107, P234, DOI 10.1016/j.neuron.2020.06.002
   Bilici M, 2001, J AFFECT DISORDERS, V64, P43, DOI 10.1016/S0165-0327(00)00199-3
   Boden JM, 2011, ADDICTION, V106, P906, DOI 10.1111/j.1360-0443.2010.03351.x
   Castro-Martín L, 2021, MATHEMATICS-BASEL, V9, DOI 10.3390/math9232991
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   DAVIDSON J, 1986, PSYCHIAT RES, V17, P87, DOI 10.1016/0165-1781(86)90063-6
   Dikalov S, 2019, AM J PHYSIOL-HEART C, V316, pH639, DOI 10.1152/ajpheart.00595.2018
   Dold M, 2021, PROG NEURO-PSYCHOPH, V110, DOI 10.1016/j.pnpbp.2021.110285
   Evans DL, 2005, BIOL PSYCHIAT, V58, P175, DOI 10.1016/j.biopsych.2005.05.001
   Fernandes BM, 2022, EUR J CLIN PHARMACOL, V78, P339, DOI 10.1007/s00228-021-03240-8
   Ferrando L, 2000, Instrum Deteccion Orientacion Diagnostica, P1
   Fiksdal A, 2019, PSYCHONEUROENDOCRINO, V102, P44, DOI 10.1016/j.psyneuen.2018.11.035
   Foley EM, 2021, COMPR PSYCHONEUROEND, V8, DOI 10.1016/j.cpnec.2021.100079
   Gaynes BN, 2009, PSYCHIAT SERV, V60, P1439, DOI 10.1176/ps.2009.60.11.1439
   Gevrey M, 2003, ECOL MODEL, V160, P249, DOI 10.1016/S0304-3800(02)00257-0
   Gleeson M, 2011, NAT REV IMMUNOL, V11, P607, DOI 10.1038/nri3041
   Godin O, 2019, J CLIN PSYCHIAT, V80, DOI 10.4088/JCP.19m12755
   Graham S, 2019, CURR PSYCHIAT REP, V21, DOI 10.1007/s11920-019-1094-0
   Haroon E, 2018, PSYCHONEUROENDOCRINO, V95, P43, DOI 10.1016/j.psyneuen.2018.05.026
   Hickman RJ, 2014, J BEHAV MED, V37, P621, DOI 10.1007/s10865-013-9510-0
   Hoare E, 2016, INT J BEHAV NUTR PHY, V13, DOI 10.1186/s12966-016-0432-4
   Horowitz MA, 2020, BRAIN BEHAV IMMUN, V87, P777, DOI 10.1016/j.bbi.2020.03.012
   KANNEL WB, 1980, CIRCULATION, V61, P1179, DOI 10.1161/01.CIR.61.6.1179
   Karlovic D, 2012, PSYCHIAT RES, V198, P74, DOI 10.1016/j.psychres.2011.12.007
   Kuhn M., 2013, Springer, V1st, DOI DOI 10.1007/978-1-4614-6849-3
   Lamers F, 2013, MOL PSYCHIATR, V18, P692, DOI 10.1038/mp.2012.144
   Lamers F, 2020, BRAIN BEHAV IMMUN, V88, P174, DOI 10.1016/j.bbi.2020.04.002
   Lanquillon S, 2000, NEUROPSYCHOPHARMACOL, V22, P370, DOI 10.1016/S0893-133X(99)00134-7
   Lasserre AM, 2017, MOL PSYCHIATR, V22, P1026, DOI 10.1038/mp.2016.178
   Lee J, 2021, J AFFECT DISORDERS, V295, P1494, DOI 10.1016/j.jad.2021.09.043
   Li G, 2019, ANN GEN PSYCHIATR, V18, DOI 10.1186/s12991-019-0248-0
   Liu YZ, 2017, FRONT HUM NEUROSCI, V11, DOI 10.3389/fnhum.2017.00316
   Lotrich FE, 2015, BRAIN RES, V1617, P113, DOI 10.1016/j.brainres.2014.06.032
   Ma K, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17050733
   Maddatu J, 2017, TRANSL RES, V184, P101, DOI 10.1016/j.trsl.2017.02.004
   Maes M, 2011, NEUROENDOCRINOL LETT, V32, P7
   Mahmood SS, 2014, LANCET, V383, P999, DOI 10.1016/S0140-6736(13)61752-3
   Mammen G, 2013, AM J PREV MED, V45, P649, DOI 10.1016/j.amepre.2013.08.001
   Martland R, 2020, J SPORT SCI, V38, P430, DOI 10.1080/02640414.2019.1706829
   Mathers CD, 2006, PLOS MED, V3, DOI 10.1371/journal.pmed.0030442
   Mathew AR, 2017, ADDICTION, V112, P401, DOI 10.1111/add.13604
   Matza LS, 2003, ARCH GEN PSYCHIAT, V60, P817, DOI 10.1001/archpsyc.60.8.817
   Mazereeuw G, 2015, NEUROPSYCH DIS TREAT, V11, P2479, DOI 10.2147/NDT.S89922
   Mikkelsen K, 2017, MATURITAS, V106, P48, DOI 10.1016/j.maturitas.2017.09.003
   Milaneschi Y, 2021, MOL PSYCHIATR, V26, P7393, DOI 10.1038/s41380-021-01188-w
   Moriarity DP, 2021, BRAIN BEHAV IMMUN, V93, P35, DOI 10.1016/j.bbi.2020.12.005
   Nestler E.J., 2001, MOL NEUROPHRAMACOLOG, P200
   Osimo EF, 2019, PSYCHOL MED, V49, P1958, DOI 10.1017/S0033291719001454
   Petersen AMW, 2005, J APPL PHYSIOL, V98, P1154, DOI 10.1152/japplphysiol.00164.2004
   Powers SK, 2020, J SPORT HEALTH SCI, V9, P415, DOI 10.1016/j.jshs.2020.04.001
   Prochaska JJ, 2017, ANNU REV PUBL HEALTH, V38, P165, DOI 10.1146/annurev-publhealth-031816-044618
   Puddephatt JA, 2022, ADDICTION, V117, P1543, DOI 10.1111/add.15735
   Puddey IB, 2019, CURR HYPERTENS REP, V21, DOI 10.1007/s11906-019-0984-1
   Qamar N, 2019, BEHAV BRAIN RES, V376, DOI 10.1016/j.bbr.2019.112196
   Qiu WX, 2021, FRONT NEUROSCI-SWITZ, V15, DOI 10.3389/fnins.2021.728810
   Quitkin Frederic M., 2002, Prim Care Companion J Clin Psychiatry, V4, P94
   Rae CD, 2017, ANAL BIOCHEM, V529, P127, DOI 10.1016/j.ab.2016.12.022
   Raison CL, 2011, CURR PSYCHIAT REP, V13, P467, DOI 10.1007/s11920-011-0232-0
   Rajan TM, 2017, J POSTGRAD MED, V63, P182, DOI 10.4103/jpgm.JPGM_712_16
   Rakotomamonjy A., 2003, Journal of Machine Learning Research, V3, P1357, DOI 10.1162/153244303322753706
   Refaeilzadeh P., 2009, Encyclopedia of Database Systems, DOI [DOI 10.1007/978-0-387-39940-9565, 10.1007/978-0-387-39940-9_565, DOI 10.1007/978-0-387-39940-9_565]
   Roberts SH, 2011, J ADV NURS, V67, P690, DOI 10.1111/j.1365-2648.2010.05546.x
   Schuch FB, 2015, J PSYCHIATR RES, V61, P25, DOI 10.1016/j.jpsychires.2014.11.005
   Shao TY, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.751374
   Shatte ABR, 2019, PSYCHOL MED, V49, P1426, DOI 10.1017/S0033291719000151
   Sluzewska A, 1997, NEUROPSYCHOBIOLOGY, V35, P123, DOI 10.1159/000119332
   Sramek JJ, 2016, DIALOGUES CLIN NEURO, V18, P447
   Sterne JAC, 2009, BMJ-BRIT MED J, V339, DOI 10.1136/bmj.b2393
   Strawbridge R, 2019, J AFFECT DISORDERS, V246, P42, DOI 10.1016/j.jad.2018.12.037
   Sullivan LE, 2005, AM J MED, V118, P330, DOI 10.1016/j.amjmed.2005.01.007
   Teskey G, 2018, ADV CLIN CHEM, V87, P141, DOI 10.1016/bs.acc.2018.07.004
   Thase Michael E., 1995, P1081
   Uher R, 2014, AM J PSYCHIAT, V171, P1278, DOI 10.1176/appi.ajp.2014.14010094
   van Gool CH, 2003, AGE AGEING, V32, P81, DOI 10.1093/ageing/32.1.81
   Vancampfort D, 2015, PSYCHIAT DANUB, V27, P210
   Vapnik V.N, 1998, STADITICAL LEARNING
   Vermeiden M, 2010, J PSYCHOPHARMACOL, V24, P497, DOI 10.1177/0269881109105137
   Weinberger AH, 2017, AM J DRUG ALCOHOL AB, V43, P416, DOI 10.3109/00952990.2016.1171327
   World Health Organization, 2017, WHOMSDMER20172
   Xu QY, 2011, OBES RES CLIN PRACT, V5, pE267, DOI 10.1016/j.orcp.2011.04.007
   Yang CH, 2018, J PSYCHOSOM RES, V111, P58, DOI 10.1016/j.jpsychores.2018.05.008
   Zainal NH, 2021, J ABNORM PSYCHOL, V130, P829, DOI 10.1037/abn0000716
   Zalachoras I, 2020, NEUROSCI BIOBEHAV R, V114, P134, DOI 10.1016/j.neubiorev.2020.03.015
   Zhu CB, 2006, NEUROPSYCHOPHARMACOL, V31, P2121, DOI 10.1038/sj.npp.1301029
NR 88
TC 11
Z9 11
U1 0
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD MAR 8
PY 2023
VL 121
AR 110674
DI 10.1016/j.pnpbp.2022.110674
EA NOV 2022
PG 10
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 7B8NL
UT WOS:000899384000003
PM 36332700
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Contreras, C
   González-García, I
   Martínez-Sánchez, N
   Seoane-Collazo, P
   Jacas, J
   Morgan, DA
   Serra, D
   Gallego, R
   Gonzalez, F
   Casals, N
   Nogueiras, R
   Rahmouni, K
   Diéguez, C
   López, M
AF Contreras, Cristina
   Gonzalez-Garcia, Ismael
   Martinez-Sanchez, Noelia
   Seoane-Collazo, Patricia
   Jacas, Jordi
   Morgan, Donald A.
   Serra, Dolors
   Gallego, Rosalia
   Gonzalez, Francisco
   Casals, Nuria
   Nogueiras, Ruben
   Rahmouni, Kamal
   Dieguez, Carlos
   Lopez, Miguel
TI Central Ceramide-Induced Hypothalamic Lipotoxicity and ER Stress
   Regulate Energy Balance
SO CELL REPORTS
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; BROWN ADIPOSE-TISSUE; UNFOLDED PROTEIN
   RESPONSE; INSULIN-RESISTANCE; METABOLIC SYNDROME; LEPTIN RESISTANCE;
   HEPATIC STEATOSIS; OBESITY; KINASE; NEURONS
AB Hypothalamic endoplasmic reticulum (ER) stress is a key mechanism leading to obesity. Here, we demonstrate that ceramides induce lipotoxicity and hypothalamic ER stress, leading to sympathetic inhibition, reduced brown adipose tissue (BAT) thermogenesis, and weight gain. Genetic overexpression of the chaperone GRP78/BiP (glucose-regulated protein 78 kDa/binding immunoglobulin protein) in the ventromedial nucleus of the hypothalamus (VMH) abolishes ceramide action by reducing hypothalamic ER stress and increasing BAT thermogenesis, which leads to weight loss and improved glucose homeostasis. The pathophysiological relevance of this mechanism is demonstrated in obese Zucker rats, which show increased hypothalamic ceramide levels and ER stress. Overexpression of GRP78 in the VMH of these animals reduced body weight by increasing BAT thermogenesis as well as decreasing leptin and insulin resistance and hepatic steatosis. Overall, these data identify a triangulated signaling network involving central ceramides, hypothalamic lipotoxicity/ER stress, and BAT thermogenesis as a pathophysiological mechanism of obesity.
C1 [Contreras, Cristina; Gonzalez-Garcia, Ismael; Martinez-Sanchez, Noelia; Seoane-Collazo, Patricia; Nogueiras, Ruben; Dieguez, Carlos; Lopez, Miguel] Univ Santiago de Compostela, Inst Invest Sanitaria, Dept Physiol, CIMUS, Santiago De Compostela 15782, Spain.
   [Contreras, Cristina; Gonzalez-Garcia, Ismael; Martinez-Sanchez, Noelia; Seoane-Collazo, Patricia; Jacas, Jordi; Serra, Dolors; Casals, Nuria; Nogueiras, Ruben; Dieguez, Carlos; Lopez, Miguel] CIBER Fisiopatol Obesidad & Nutr CIBERobn, Santiago De Compostela 15706, Spain.
   [Jacas, Jordi; Casals, Nuria] Univ Int Catalunya, Fac Med & Hlth Sci, Dept Basic Sci, Barcelona 08195, Spain.
   [Morgan, Donald A.; Rahmouni, Kamal] Univ Iowa, Dept Pharmacol, Iowa City, IA 52242 USA.
   [Serra, Dolors] Univ Barcelona, Inst Biomed IBUB, Sch Pharm, Dept Biochem & Mol Biol, E-08028 Barcelona, Spain.
   [Gallego, Rosalia] Univ Santiago de Compostela, Sch Med, Dept Morphol Sci, Santiago De Compostela 15782, Spain.
   [Gonzalez, Francisco] Univ Santiago de Compostela, Inst Invest Sanitaria, Dept Surg, CIMUS, Santiago De Compostela 15782, Spain.
   [Gonzalez, Francisco] Complejo Hospitalario Univ Santiago de Compostela, Serv Ophthalmol, Santiago De Compostela 15706, Spain.
   [Rahmouni, Kamal] Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA.
C3 Universidade de Santiago de Compostela; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; Universitat Internacional de Catalunya
   (UIC); University of Iowa; University of Barcelona; Universidade de
   Santiago de Compostela; Universidade de Santiago de Compostela; Complexo
   Hospitalario Universitario de Santiago de Compostela; University of Iowa
RP López, M (corresponding author), Univ Santiago de Compostela, Inst Invest Sanitaria, Dept Physiol, CIMUS, Santiago De Compostela 15782, Spain.
EM m.lopez@usc.es
RI Rahmouni, Kamal/Y-1788-2019; González-García, Ismael/ABG-3122-2020;
   Nogueiras, Ruben/AAS-9427-2021; Biendicho, Jordi/H-8282-2015;
   Seoane-Collazo, Patricia/AAB-8404-2019; Contreras, Cristina/N-7257-2019;
   Serra, Dolors/L-3657-2014; Casals, Nuria/L-3378-2014; Gonzalez,
   Francisco/N-4135-2014; Lopez, Miguel/ABF-4844-2021; Morgan,
   Donald/L-6907-2013
OI Serra, Dolors/0000-0002-4936-4206; Contreras,
   Cristina/0000-0002-7015-7922; Gonzalez-Garcia,
   Ismael/0000-0002-5545-5841; Seoane-Collazo,
   Patricia/0000-0002-7102-7935; Martinez-Sanchez,
   Noelia/0000-0003-4580-8196; Casals, Nuria/0000-0002-6719-4300;
   Nogueiras, Ruben/0000-0002-9976-9930; Rosalia,
   Gallego/0000-0002-6015-4680; Rahmouni, Kamal/0000-0001-5136-6748;
   Gonzalez, Francisco/0000-0002-1461-5474; dieguez,
   carlos/0000-0002-0919-4337; Lopez, Miguel/0000-0002-7823-1648; Morgan,
   Donald/0000-0003-3167-1643
FU European Community's Seventh Framework Programme (FP7) [281854];
   ObERStress European Research Council Project [245009]; Neurofast
   project; Xunta de Galicia [10PXIB208126PR, EM 2012/039, 2012-CP069,
   2012-CP070]; Instituto de Salud Carlos III (ISCIII) [PI12/01814];
   MINECO; FEDER Program of EU [BFU-2010-14968, SAF2011-30520-C02-01,
   BFU2012-35255, SAF2011-30520-C02-02, BFU2011-29102]; NIH [HL084207];
   Ministerio de Educacion, Cultura y Deporte [FPU12/01827]; National Heart
   Lung and Blood Institute [P01HL084207] Funding Source: NIH RePORTER
FX The research leading to these results has received funding from the
   European Community's Seventh Framework Programme (FP7/2007-2013) under
   grant agreement no. 281854, the ObERStress European Research Council
   Project (M. L.), and 245009, the Neurofast project (R.N., C. D., and M.
   L.), Xunta de Galicia (F. G., 10PXIB208126PR; R.N., EM 2012/039 and
   2012-CP069; M. L., 2012-CP070), Instituto de Salud Carlos III (ISCIII;
   M. L., PI12/01814), MINECO cofunded by the FEDER Program of EU (F. G.,
   BFU-2010-14968; D. S., SAF2011-30520-C02-01; R.N., BFU2012-35255; N. C.,
   SAF2011-30520-C02-02; C. D., BFU2011-29102), and the NIH (K. R.:
   HL084207). I. G.-G. is a recipient of a fellowship from Ministerio de
   Educacion, Cultura y Deporte (FPU12/01827). CIBER de Fisiopatologia de
   la Obesidad y Nutricion is an initiative of ISCIII. The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
CR Beiroa D., 2014, DIABETES
   Beiroa D, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054591
   Bikman BT, 2011, J CLIN INVEST, V121, P4222, DOI 10.1172/JCI57144
   de Morentin PBM, 2010, PLOS BIOL, V8, DOI 10.1371/journal.pbio.1000464
   Borg ML, 2012, J PHYSIOL-LONDON, V590, P4377, DOI 10.1113/jphysiol.2012.233288
   Cannon B, 2004, PHYSIOL REV, V84, P277, DOI 10.1152/physrev.00015.2003
   Car H, 2012, FEBS J, V279, P1943, DOI 10.1111/j.1742-4658.2012.08575.x
   Caro JF, 1996, LANCET, V348, P159, DOI 10.1016/S0140-6736(96)03173-X
   Chavez JA, 2012, CELL METAB, V15, P585, DOI 10.1016/j.cmet.2012.04.002
   Cnop M, 2012, TRENDS MOL MED, V18, P59, DOI 10.1016/j.molmed.2011.07.010
   Cowart LA, 2009, TRENDS ENDOCRIN MET, V20, P34, DOI 10.1016/j.tem.2008.09.004
   Dietrich MO, 2012, NAT REV DRUG DISCOV, V11, P675, DOI 10.1038/nrd3739
   Finan B, 2012, NAT MED, V18, P1847, DOI 10.1038/nm.3009
   Gao S, 2011, P NATL ACAD SCI USA, V108, P9691, DOI 10.1073/pnas.1103267108
   Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
   Hannun YA, 2008, NAT REV MOL CELL BIO, V9, P139, DOI 10.1038/nrm2329
   HENDERSHOT LM, 1995, MOL BIOL CELL, V6, P283, DOI 10.1091/mbc.6.3.283
   Holland WL, 2008, ENDOCR REV, V29, P381, DOI 10.1210/er.2007-0025
   Holland WL, 2007, CELL METAB, V5, P167, DOI 10.1016/j.cmet.2007.01.002
   Hosoi T, 2008, MOL PHARMACOL, V74, P1610, DOI 10.1124/mol.108.050070
   Howard JK, 2004, NAT MED, V10, P734, DOI 10.1038/nm1072
   Ilieva EV, 2007, BRAIN, V130, P3111, DOI 10.1093/brain/awm190
   Kahn SE, 2006, NATURE, V444, P840, DOI 10.1038/nature05482
   Kammoun HL, 2009, J CLIN INVEST, V119, P1201, DOI 10.1172/JCI37007
   Lam TKT, 2005, NAT NEUROSCI, V8, P579, DOI 10.1038/nn1456
   Lipson KL, 2006, CELL METAB, V4, P245, DOI 10.1016/j.cmet.2006.07.007
   López M, 2008, CELL METAB, V7, P389, DOI 10.1016/j.cmet.2008.03.006
   López M, 2013, TRENDS MOL MED, V19, P418, DOI 10.1016/j.molmed.2013.04.004
   López M, 2010, NAT MED, V16, P1001, DOI 10.1038/nm.2207
   Luquet Serge, 2009, Front Biosci (Schol Ed), V1, P448
   Malik VS, 2013, NAT REV ENDOCRINOL, V9, P13, DOI 10.1038/nrendo.2012.199
   Marciniak SJ, 2006, PHYSIOL REV, V86, P1133, DOI 10.1152/physrev.00015.2006
   de Morentin PBM, 2014, CELL METAB, V20, P41, DOI 10.1016/j.cmet.2014.03.031
   de Morentin PBM, 2012, DIABETES, V61, P807, DOI 10.2337/db11-1079
   de Morentin PBM, 2010, BBA-MOL CELL BIOL L, V1801, P350, DOI 10.1016/j.bbalip.2009.09.016
   McCrimmon RJ, 2006, DIABETES, V55, P1755, DOI 10.2337/db05-1359
   Mitoma J, 1998, J NEUROSCI RES, V51, P712, DOI 10.1002/(SICI)1097-4547(19980315)51:6<712::AID-JNR5>3.3.CO;2-Q
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Ozcan L, 2009, CELL METAB, V9, P35, DOI 10.1016/j.cmet.2008.12.004
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Phillips MS, 1996, NAT GENET, V13, P18, DOI 10.1038/ng0596-18
   Picard A, 2014, MOL METAB, V3, P167, DOI 10.1016/j.molmet.2013.11.002
   Ramachandrappa S, 2011, J CLIN INVEST, V121, P2080, DOI 10.1172/JCI46044
   Ramírez S, 2013, DIABETES, V62, P2329, DOI 10.2337/db12-1451
   Ron D, 2007, NAT REV MOL CELL BIO, V8, P519, DOI 10.1038/nrm2199
   Ropelle ER, 2010, PLOS BIOL, V8, DOI 10.1371/journal.pbio.1000465
   Schneeberger M, 2013, CELL, V155, P172, DOI 10.1016/j.cell.2013.09.003
   Schröder M, 2005, ANNU REV BIOCHEM, V74, P739, DOI 10.1146/annurev.biochem.73.011303.074134
   Seoane-Collazo P, 2014, ENDOCRINOLOGY, V155, P1679, DOI 10.1210/en.2013-1839
   Shen JS, 2002, DEV CELL, V3, P99, DOI 10.1016/S1534-5807(02)00203-4
   Speakman JR, 2012, DIS MODEL MECH, V5, P569, DOI 10.1242/dmm.010553
   Summers SA, 1998, MOL CELL BIOL, V18, P5457, DOI 10.1128/MCB.18.9.5457
   Symons JD, 2013, REV ENDOCR METAB DIS, V14, P59, DOI 10.1007/s11154-012-9235-3
   Unger RH, 2002, ANNU REV MED, V53, P319, DOI 10.1146/annurev.med.53.082901.104057
   Virtue S, 2010, BBA-MOL CELL BIOL L, V1801, P338, DOI 10.1016/j.bbalip.2009.12.006
   Virtue S, 2008, PLOS BIOL, V6, P1819, DOI 10.1371/journal.pbio.0060237
   Whittle AJ, 2012, CELL, V149, P871, DOI 10.1016/j.cell.2012.02.066
   Williams KW, 2012, NAT NEUROSCI, V15, P1350, DOI 10.1038/nn.3217
   Won JC, 2009, OBESITY, V17, P1861, DOI 10.1038/oby.2009.194
   Yang G, 2009, AM J PHYSIOL-ENDOC M, V297, pE211, DOI 10.1152/ajpendo.91014.2008
   Yeo GSH, 2012, NAT NEUROSCI, V15, P1343, DOI 10.1038/nn.3211
   Zhang XQ, 2008, CELL, V135, P61, DOI 10.1016/j.cell.2008.07.043
NR 62
TC 193
Z9 207
U1 0
U2 28
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 2211-1247
J9 CELL REP
JI Cell Reports
PD OCT 9
PY 2014
VL 9
IS 1
BP 366
EP 377
DI 10.1016/j.celrep.2014.08.057
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA AS7YP
UT WOS:000344468100031
PM 25284795
OA Green Accepted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Jia, GH
   Sowers, JR
AF Jia, Guanghong
   Sowers, James R.
TI Autophagy: A housekeeper in cardiorenal metabolic health and disease
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Review
DE Autophagy; Cardiorenal metabolic syndrome; Insulin resistance; Obesity;
   Endoplasmic reticulum stress; Reactive oxygen species
ID ACTIVATED PROTEIN-KINASE; PANCREATIC BETA-CELLS; DIET-INDUCED OBESITY;
   INSULIN-RESISTANCE; DIABETES-MELLITUS; CARDIAC AUTOPHAGY;
   VASCULAR-DISEASE; DYSFUNCTION; AMPK; STRESS
AB Autophagy, literally translated means self-eating, is a primary degradative pathway and plays an important role in the regulation of cellular homeostasis through elimination of aggregated proteins, damaged organelles, and intracellular pathogens. Autophagy has been classified into microautophagy, macroautophagy, and chaperonemediated autophagy, depending on the choice of the pathway by which the cellular material is delivered to lysosomes. Dysregulation of autophagy may contribute to the development of cardiorenal metabolic syndrome (CRS), including insulin resistance, obesity, hypertension, maladaptive immune modulation, and associated cardiac and renal disease. Clarifying the pathways and mechanisms of autophagy under normal conditions is essential to understanding its dysregulation in the development of CRS. Here, we highlight a recent surge in autophagy research, such as the cellular quality control through the disposal and recycling of cellular components, and summarize our contemporary understanding of molecular mechanisms of autophagy in diverse organ or tissues involved in the pathogenesis of CRS. This article is part of a Special Issue entitled: Autophagy and protein quality control in cardiometabolic diseases. (C) 2014 Published by Elsevier B.V.
C1 [Jia, Guanghong; Sowers, James R.] Univ Missouri, Sch Med, Diabet Cardiovasc Ctr, Div Endocrinol, Columbia, MO USA.
   [Jia, Guanghong; Sowers, James R.] Univ Missouri, Sch Med, Diabet Cardiovasc Ctr, Div Diabet, Columbia, MO USA.
   [Jia, Guanghong; Sowers, James R.] Univ Missouri, Sch Med, Diabet Cardiovasc Ctr, Div Hypertens, Columbia, MO USA.
   [Jia, Guanghong; Sowers, James R.] Univ Missouri, Sch Med, Diabet Cardiovasc Ctr, Div Metab, Columbia, MO USA.
   [Sowers, James R.] Univ Missouri, Sch Med, Dept Med Pharmacol, Columbia, MO USA.
   [Sowers, James R.] Univ Missouri, Sch Med, Dept Physiol, Columbia, MO 65212 USA.
   [Jia, Guanghong; Sowers, James R.] Univ Missouri, Sch Med, Harry S Truman Mem Vet Hosp, Columbia, MO USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital
RP Sowers, JR (corresponding author), Univ Missouri, D109 Diabet Ctr HSC,One Hosp Dr, Columbia, MO 65212 USA.
EM sowersj@health.missouri.edu
FU NIH [R01 HL73101-01A, R01 HL107910-01]; Veterans Affairs Merit System
   [0018]
FX The authors would like to thank Brenda Hunter for her editorial
   assistance. This research was supported by NIH (R01 HL73101-01A, R01
   HL107910-01) and the Veterans Affairs Merit System (0018) for JRS.
CR Aroor Annayya R, 2013, Front Endocrinol (Lausanne), V4, P161, DOI 10.3389/fendo.2013.00161
   Aroor AR, 2012, CARDIORENAL MED, V2, P87, DOI 10.1159/000335675
   Bender SB, 2013, DIABETES, V62, P313, DOI 10.2337/db12-0905
   Borlaug BA, 2011, EUR HEART J, V32, P670, DOI 10.1093/eurheartj/ehq426
   Cheema MU, 2013, PHYSIOL REP, V1, DOI 10.1002/phy2.64
   Chen YY, 2013, INT J MOL MED, V32, P1401, DOI 10.3892/ijmm.2013.1530
   Dodson M, 2013, FREE RADICAL BIO MED, V63, P207, DOI 10.1016/j.freeradbiomed.2013.05.014
   Faulds MH, 2012, J ENDOCRINOL, V212, P3, DOI 10.1530/JOE-11-0044
   Feng YC, 2014, CELL RES, V24, P24, DOI 10.1038/cr.2013.168
   Gonzalez CD, 2011, AUTOPHAGY, V7, P2, DOI 10.4161/auto.7.1.13044
   Gozuacik D, 2004, ONCOGENE, V23, P2891, DOI 10.1038/sj.onc.1207521
   Guo R, 2013, BBA-MOL BASIS DIS, V1832, P1136, DOI 10.1016/j.bbadis.2013.03.013
   Hsu PC, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0049100
   Jiang YL, 2014, INT J BIOL SCI, V10, P268, DOI 10.7150/ijbs.7929
   Jing K, 2012, EXP MOL MED, V44, P69, DOI 10.3858/emm.2012.44.2.028
   Kim KH, 2014, NAT REV ENDOCRINOL, V10, P322, DOI 10.1038/nrendo.2014.35
   Kim KH, 2014, REV ENDOCR METAB DIS, V15, P11, DOI 10.1007/s11154-013-9272-6
   Kovsan J, 2011, J CLIN ENDOCR METAB, V96, pE268, DOI 10.1210/jc.2010-1681
   Koya D, 2014, CLIN EXP NEPHROL, V18, P210, DOI 10.1007/s10157-013-0908-3
   Kubli DA, 2014, TRENDS ENDOCRIN MET, V25, P156, DOI 10.1016/j.tem.2013.11.004
   Lastra G, 2006, ADV CHRONIC KIDNEY D, V13, P365, DOI 10.1053/j.ackd.2006.07.011
   Lastra G, 2014, ENDOCRIN METAB CLIN, V43, P103, DOI 10.1016/j.ecl.2013.09.005
   Li HL, 2014, AM J PHYSIOL-ENDOC M, V306, pE197, DOI 10.1152/ajpendo.00202.2013
   Liu JK, 2009, ADV DRUG DELIVER REV, V61, P1343, DOI 10.1016/j.addr.2009.06.007
   Liu Y, 2005, CELL, V121, P567, DOI 10.1016/j.cell.2005.03.007
   Ma TA, 2013, EXP CELL RES, V319, P779, DOI 10.1016/j.yexcr.2013.01.018
   Mandavia CH, 2012, METABOLISM, V61, P1205, DOI 10.1016/j.metabol.2012.02.013
   Martinet W, 2008, CURR ATHEROSCLER REP, V10, P216, DOI 10.1007/s11883-008-0034-y
   Matsui Y, 2007, CIRC RES, V100, P914, DOI 10.1161/01.RES.0000261924.76669.36
   Mazza S, 2014, VITAM HORM, V95, P145, DOI 10.1016/B978-0-12-800174-5.00006-5
   Ng F, 2013, J CELL PHYSIOL, V228, P2262, DOI 10.1002/jcp.24399
   Nuñez CE, 2013, INT J OBESITY, V37, P1473, DOI 10.1038/ijo.2013.27
   Ouyang CH, 2014, J MOL CELL CARDIOL, V71, P71, DOI 10.1016/j.yjmcc.2013.10.014
   Pillai VB, 2014, CIRC RES, V114, P368, DOI 10.1161/CIRCRESAHA.113.300536
   Polak-Jonkisz D, 2013, J PHYSIOL BIOCHEM, V69, P957, DOI 10.1007/s13105-013-0268-1
   Porrello ER, 2009, AUTOPHAGY, V5, P1215, DOI 10.4161/auto.5.8.10153
   Pyo JO, 2013, DIABETES METAB J, V37, P333, DOI 10.4093/dmj.2013.37.5.333
   Quan W, 2013, ARCH PHARM RES, V36, P223, DOI 10.1007/s12272-013-0024-7
   Ren J, 2010, J MOL MED, V88, P993, DOI 10.1007/s00109-010-0663-9
   Roach PJ, 2011, MOL CELL BIOL, V31, P3082, DOI 10.1128/MCB.05565-11
   Salabei JK, 2013, FREE RADICAL BIO MED, V65, P693, DOI 10.1016/j.freeradbiomed.2013.08.003
   Salabei JK, 2013, CARDIOVASC TOXICOL, V13, P220, DOI 10.1007/s12012-013-9200-8
   Shintani T, 2004, SCIENCE, V306, P990, DOI 10.1126/science.1099993
   Sowers JR, 2013, HYPERTENSION, V61, P943, DOI 10.1161/HYPERTENSIONAHA.111.00612
   Sowers JR, 2012, DIABETES, V61, P265, DOI 10.2337/db11-1495
   Su J, 2013, J DIABETES RES, V2013, DOI 10.1155/2013/193461
   Tanaka Y, 2012, EXP DIABETES RES, DOI 10.1155/2012/628978
   Wang Y, 2013, AUTOPHAGY, V9, P272, DOI 10.4161/auto.23628
   Weckman A, 2014, J MOL ENDOCRINOL, V52, pR151, DOI 10.1530/JME-13-0241
   Whaley-Connell A, 2011, HYPERTENSION, V58, P991, DOI 10.1161/HYPERTENSIONAHA.111.180406
   Whaley-Connell A, 2009, HYPERTENSION, V54, P462, DOI 10.1161/HYPERTENSIONAHA.109.134460
   Xie ZL, 2011, AUTOPHAGY, V7, P1254, DOI 10.4161/auto.7.10.16740
   Xie ZL, 2011, DIABETES, V60, P1770, DOI 10.2337/db10-0351
   Xu J, 2012, CRIT REV FOOD SCI, V52, P373, DOI 10.1080/10408398.2010.500245
   Xu XH, 2013, CARDIOVASC RES, V99, P412, DOI 10.1093/cvr/cvt116
   Xu XH, 2013, J MOL CELL BIOL, V5, P61, DOI 10.1093/jmcb/mjs055
   Xu XH, 2012, CLIN EXP PHARMACOL P, V39, P200, DOI 10.1111/j.1440-1681.2011.05638.x
   Yadav A, 2010, AM J PHYSIOL-CELL PH, V299, pC488, DOI 10.1152/ajpcell.00424.2009
   Yamada E, 2012, DIABETES, V61, P272, DOI 10.2337/db11-1199
   Yamahara K, 2013, J DIABETES RES, V2013, DOI 10.1155/2013/193757
   Yin JJ, 2014, J LEUKOCYTE BIOL, V95, P47, DOI 10.1189/jlb.0313143
   Zapolski T, 2011, KARDIOL POL, V69, P319
   Zhang Y, 2012, PHARMACOL RES, V66, P505, DOI 10.1016/j.phrs.2012.09.004
   Zhu HX, 2007, J CLIN INVEST, V117, P1782, DOI 10.1172/JCI27523
NR 64
TC 45
Z9 53
U1 0
U2 27
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 0006-3002
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD FEB
PY 2015
VL 1852
IS 2
SI SI
BP 219
EP 224
DI 10.1016/j.bbadis.2014.06.025
PG 6
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA CA5QR
UT WOS:000348963400005
PM 24984281
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Suzuki, I
   Yamauchi, T
   Onuma, M
   Nozaki, S
AF Suzuki, Iwao
   Yamauchi, Takayuki
   Onuma, Masahiro
   Nozaki, Shigeo
TI ALLOPURINOL, AN INHIBITOR OF URIC ACID SYNTHESIS - CAN IT BE USED FOR
   THE TREATMENT OF METABOLIC SYNDROME AND RELATED DISORDERS?
SO DRUGS OF TODAY
LA English
DT Review
ID FATTY LIVER-DISEASE; XANTHINE OXIDOREDUCTASE ACTIVITY; IMPROVES
   ENDOTHELIAL FUNCTION; CHRONIC-KIDNEY-DISEASE; PANCREATIC STELLATE CELL;
   STEVENS-JOHNSON-SYNDROME; TUMOR LYSIS SYNDROME; OXIDATIVE STRESS;
   RISK-FACTORS; GLOMERULAR HYPERTENSION
AB Allopurinol is an inhibitor of xanthine oxidoreductase (XOR) and inhibits the generation of uric acid (UA) as the final product of purine catabolism, as well as the resulting generation of superoxide (O-2(-)), in humans. Elevation of the serum UA (SUA) level, referred to as hyperuricemia (HU), eventually leads to gout and allopurinol has been used for the treatment of HU and gout. Studies have revealed the role of elevated SUA levels and the associated oxidative stress (OS) in a broad spectrum of pathological conditions and it is anticipated that these findings would also expand the use of allopurinol as a therapeutic drug. This article presents a review of reports, mainly of recent studies, on the efficacy of allopurinol in various diseases and explores novel potential uses of the drug. Important novel and potential uses of great interest include metabolic syndrome (MetS) and related disorders, chronic kidney disease (CKD), nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Ischemia-reperfusion injury and mucositis, encountered as adverse effects of cancer treatment, have also been under investigation as potential targets for allopurinol.
C1 [Suzuki, Iwao; Yamauchi, Takayuki; Onuma, Masahiro; Nozaki, Shigeo] GlaxoSmithKline KK, Gen Pharma Franchise, Shibuya Ku, Tokyo 1518566, Japan.
C3 GlaxoSmithKline; GlaxoSmithKline Japan
RP Suzuki, I (corresponding author), GlaxoSmithKline KK, Gen Pharma Franchise, Shibuya Ku, 6-15 Sendagaya,4 Chome, Tokyo 1518566, Japan.
EM Iwao.Suzuki@gsk.com
CR AMAYA Y, 1990, J BIOL CHEM, V265, P14170
   Anzai N, 2007, EXPERT OPIN DRUG DIS, V2, P1251, DOI 10.1517/17460441.2.9.1251
   Baskol G, 2007, CLIN BIOCHEM, V40, P776, DOI 10.1016/j.clinbiochem.2007.02.006
   Becker MA, 2006, RHEUM DIS CLIN N AM, V32, P275, DOI 10.1016/j.rdc.2006.02.005
   Behrens MD, 2008, BLOOD, V111, P1472, DOI 10.1182/blood-2007-10-117184
   Berry CE, 2004, J PHYSIOL-LONDON, V555, P589, DOI 10.1113/jphysiol.2003.055913
   Bickel A, 2007, ANN SURG, V246, P31, DOI 10.1097/01.sla.0000262784.44278.b5
   Browning JD, 2004, J CLIN INVEST, V114, P147, DOI 10.1172/JCI200422422
   Budhiraja R, 2007, J CLIN SLEEP MED, V3, P409
   Calamita G, 2007, EXPERT OPIN THER TAR, V11, P1231, DOI 10.1517/14728222.11.9.1231
   Casillas-Ramírez A, 2006, LIFE SCI, V79, P1881, DOI 10.1016/j.lfs.2006.06.024
   Chaves FJ, 2007, PHARMACOGENET GENOM, V17, P589, DOI 10.1097/01.fpc.0000239970.23723.38
   Chen CH, 2006, J CLIN GASTROENTEROL, V40, P745, DOI 10.1097/00004836-200609000-00016
   Cheung KJ, 2007, CELL METAB, V5, P115, DOI 10.1016/j.cmet.2007.01.005
   Choi HK, 2007, AM J MED, V120, P442, DOI 10.1016/j.amjmed.2006.06.040
   Coiffier B, 2008, J CLIN ONCOL, V26, P2767, DOI 10.1200/JCO.2007.15.0177
   Conwell DL, 2008, CURR OPIN GASTROEN, V24, P586, DOI 10.1097/MOG.0b013e32830b10fb
   Coresh J, 2003, AM J KIDNEY DIS, V41, P1, DOI 10.1053/ajkd.2003.50007
   Daghini E, 2006, AM J PHYSIOL-REG I, V290, pR609, DOI 10.1152/ajpregu.00436.2005
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   Dehghan A, 2008, DIABETES CARE, V31, P361, DOI 10.2337/dc07-1276
   Domrongkitchaiporn S, 2005, J AM SOC NEPHROL, V16, P791, DOI 10.1681/ASN.2004030208
   Ei-Wahsh M, 2007, HEPATOB PANCREAT DIS, V6, P12
   El Solh AA, 2006, EUR RESPIR J, V27, P997, DOI 10.1183/09031936.06.00101005
   ELION GB, 1989, BIOSCIENCE REP, V9, P509, DOI 10.1007/BF01119794
   ERHARD J, 1994, TRANSPLANT INT, V7, P177, DOI 10.1007/BF00327084
   FABREGAT I, 1987, BIOCHEM BIOPH RES CO, V146, P920, DOI 10.1016/0006-291X(87)90618-8
   FACCHINI F, 1991, JAMA-J AM MED ASSOC, V266, P3008, DOI 10.1001/jama.266.21.3008
   Fam AG, 2002, J RHEUMATOL, V29, P1350
   Farmer SR, 2006, CELL METAB, V4, P263, DOI 10.1016/j.cmet.2006.07.001
   Farrell GC, 2006, HEPATOLOGY, V43, pS99, DOI 10.1002/hep.20973
   Ferrara N, 2007, ANNU REV MED, V58, P491, DOI 10.1146/annurev.med.58.061705.145635
   Fox NE, 1998, FREE RADICAL BIO MED, V24, P900, DOI 10.1016/S0891-5849(97)00369-9
   Fukuchi Y, 2004, RESPIROLOGY, V9, P458, DOI 10.1111/j.1440-1843.2004.00637.x
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   George J, 2008, CARDIOVASC THER, V26, P59, DOI 10.1111/j.1527-3466.2007.00029.x
   George J, 2006, CIRCULATION, V114, P2508, DOI 10.1161/CIRCULATIONAHA.106.651117
   GREENE EL, 1992, AM J PHYSIOL, V263, pF251, DOI 10.1152/ajprenal.1992.263.2.F251
   Grus FH, 2003, EUR J OPHTHALMOL, V13, P185, DOI 10.1177/112067210301300210
   Gwinner W, 2006, KIDNEY INT, V69, P481, DOI 10.1038/sj.ki.5000121
   Hanawa T, 2004, DRUG DEV IND PHARM, V30, P151, DOI 10.1081/DDC-120028710
   Harris CM, 1999, J BIOL CHEM, V274, P4561, DOI 10.1074/jbc.274.8.4561
   Harrison R, 2004, DRUG METAB REV, V36, P363, DOI 10.1081/DMR-120037569
   Harrison R, 2002, FREE RADICAL BIO MED, V33, P774, DOI 10.1016/S0891-5849(02)00956-5
   Hausman D B, 2001, Obes Rev, V2, P239, DOI 10.1046/j.1467-789X.2001.00042.x
   HIKITA M, 2000, GOUT NUCL ACID METAB, V24, P139
   Hikita M, 2007, INTERNAL MED, V46, P1353, DOI 10.2169/internalmedicine.46.0045
   HILLE R, 1995, FASEB J, V9, P995, DOI 10.1096/fasebj.9.11.7649415
   Hochberg J, 2007, HAEMATOLOGICA, V93, P9, DOI 10.3324/haematol.12327
   HORIE Y, 2008, 32 HUM SCI MULT SEM
   Hu DE, 2004, CANCER RES, V64, P5059, DOI 10.1158/0008-5472.CAN-04-1586
   Ichinose M, 2003, EUR RESPIR J, V22, P457, DOI 10.1183/09031936.03.00052002
   Ichinose M, 2007, INTERNAL MED, V46, P81, DOI 10.2169/internalmedicine.46.1777
   Imai Enyu, 2007, Clin Exp Nephrol, V11, P156, DOI 10.1007/s10157-007-0463-x
   Imamura Y, 2006, P NATL ACAD SCI USA, V103, P11282, DOI 10.1073/pnas.0602131103
   Iseki K, 2004, AM J KIDNEY DIS, V44, P642, DOI [10.1016/S0272-6386(04)00934-5, 10.1053/j.ajkd.2004.06.006]
   Iseki K, 2001, HYPERTENS RES, V24, P691, DOI 10.1291/hypres.24.691
   Iseki K, 2008, INTERNAL MED, V47, P681, DOI 10.2169/internalmedicine.47.0906
   Ishizaka N, 2005, ARTERIOSCL THROM VAS, V25, P1038, DOI 10.1161/01.ATV.0000161274.87407.26
   Ishizaka N, 2007, ATHEROSCLEROSIS, V192, P131, DOI 10.1016/j.atherosclerosis.2006.04.016
   *JAP SOC GOUT NUCL, 2002, GUID MAN HYP GOUT
   *JAP SOC HEP, 2006, CLIN PRACT GUID NASH
   Jimba S, 2005, DIABETIC MED, V22, P1141, DOI 10.1111/j.1464-5491.2005.01582.x
   Kanbay M, 2007, INT UROL NEPHROL, V39, P1227, DOI 10.1007/s11255-007-9253-3
   Kaniwa N, 2008, PHARMACOGENOMICS, V9, P1617, DOI 10.2217/14622416.9.11.1617
   Karamouzis I, 2008, AM J NEPHROL, V28, P397, DOI 10.1159/000112413
   Kelley EE, 2006, FREE RADICAL BIO MED, V40, P952, DOI 10.1016/j.freeradbiomed.2005.11.008
   Kitagawa J, 2008, J RADIAT RES, V49, P49, DOI 10.1269/jrr.07038
   Kojima S, 2003, J GASTROENTEROL, V38, P954, DOI 10.1007/s00535-003-1178-8
   Komaki Y, 2005, PULM PHARMACOL THER, V18, P297, DOI 10.1016/j.pupt.2005.01.002
   Kuzkaya N, 2005, BIOCHEM PHARMACOL, V70, P343, DOI 10.1016/j.bcp.2005.05.009
   Laakso JT, 2004, J HYPERTENS, V22, P1333, DOI 10.1097/01.hjh.0000125441.28861.9f
   Lai HC, 2008, TZU CHI MED J, V20, P213, DOI 10.1016/S1016-3190(08)60038-5
   Le A, 2008, J APPL PHYSIOL, V105, P1282, DOI 10.1152/japplphysiol.90689.2008
   Lee HY, 2008, SINGAP MED J, V49, P384
   Leung PS, 2009, ANTIOXID REDOX SIGN, V11, P135, DOI 10.1089/ars.2008.2109
   Lonardo A, 2002, DIGEST LIVER DIS, V34, P204, DOI 10.1016/S1590-8658(02)80194-3
   Lonjou C, 2008, PHARMACOGENET GENOM, V18, P99, DOI 10.1097/FPC.0b013e3282f3ef9c
   LOPRINZI CL, 1990, CANCER-AM CANCER SOC, V65, P1879, DOI 10.1002/1097-0142(19900415)65:8<1879::AID-CNCR2820650834>3.0.CO;2-8
   Lotery A, 2007, HUM GENET, V122, P219, DOI 10.1007/s00439-007-0406-3
   Lysaght MJ, 2002, J AM SOC NEPHROL, V13, pS37
   Madan K, 2006, J CLIN GASTROENTEROL, V40, P930, DOI 10.1097/01.mcg.0000212608.59090.08
   MASSEY V, 1970, J BIOL CHEM, V245, P2837
   Matsuura F, 1998, METABOLISM, V47, P929, DOI 10.1016/S0026-0495(98)90346-8
   Matthay MA, 2003, AM J RESP CRIT CARE, V167, P1027, DOI 10.1164/rccm.200208-966WS
   Mazzali M, 2001, HYPERTENSION, V38, P1101, DOI 10.1161/hy1101.092839
   Méndez-Sánchez N, 2007, LIVER INT, V27, P423, DOI 10.1111/j.1478-3231.2007.01483.x
   Minami M, 2005, BLOOD PRESSURE, V14, P120, DOI 10.1080/08037050510008878
   Mittal A, 2008, WORLD J SURG, V32, P288, DOI 10.1007/s00268-007-9336-4
   Myllymäki J, 2005, NEPHROL DIAL TRANSPL, V20, P89, DOI 10.1093/ndt/gfh584
   Nakagawa T, 2006, AM J PHYSIOL-RENAL, V290, pF625, DOI 10.1152/ajprenal.00140.2005
   Namazi MR, 2004, INT IMMUNOPHARMACOL, V4, P349, DOI 10.1016/j.intimp.2004.01.022
   Nazari A, 2007, DARU, V15, P227
   Ngeow WC, 2008, ONCOL REV, V2, P102, DOI 10.1007/s12156-008-0064-2
   Ninomiya T, 2006, AM J KIDNEY DIS, V48, P383, DOI 10.1053/j.ajkd.2006.06.003
   Nishino T, 2005, J BIOL CHEM, V280, P24888, DOI 10.1074/jbc.M501830200
   NISHINO T, 1994, J BIOCHEM, V116, P1
   Nowak JZ, 2006, PHARMACOL REP, V58, P353
   Obermayr RP, 2008, NEPHROL DIAL TRANSPL, V23, P1265, DOI 10.1093/ndt/gfm790
   Obermayr RP, 2008, J AM SOC NEPHROL, V19, P2407, DOI 10.1681/ASN.2008010080
   Ohno I, 2001, NEPHRON, V87, P333, DOI 10.1159/000045939
   Okamoto H, 2003, J DERMATOL SCI, V31, P119, DOI 10.1016/S0923-1811(02)00148-2
   OLAH T, 1994, N-S ARCH PHARMACOL, V350, P96
   Omary MB, 2007, J CLIN INVEST, V117, P50, DOI 10.1172/JCI30082
   Pacher P, 2006, PHARMACOL REV, V58, P87, DOI 10.1124/pr.58.1.6
   Park SH, 2004, J GASTROEN HEPATOL, V19, P694, DOI 10.1111/j.1440-1746.2004.03362.x
   PEACHEY NS, 1993, INVEST OPHTH VIS SCI, V34, P58
   Peronato G, 2005, CONTRIB NEPHROL, V147, P1, DOI 10.1159/000082538
   Pinamonti S, 1996, FREE RADICAL BIO MED, V21, P147, DOI 10.1016/0891-5849(96)00030-5
   Pritsos CA, 2000, CHEM-BIOL INTERACT, V129, P195, DOI 10.1016/S0009-2797(00)00203-9
   Radi R, 1997, ARCH BIOCHEM BIOPHYS, V339, P125, DOI 10.1006/abbi.1996.9844
   Reddy SP, 2007, ANTIOXID REDOX SIGN, V9, P2003, DOI 10.1089/ars.2007.1770
   Reiter CD, 2000, J BIOL CHEM, V275, P32460, DOI 10.1074/jbc.M910433199
   Rubenfeld GD, 2005, NEW ENGL J MED, V353, P1685, DOI 10.1056/NEJMoa050333
   Russo G, 2008, ONCOLOGIST, V13, P886, DOI 10.1634/theoncologist.2008-0024
   Sakai T, 2007, J BIOL CHEM, V282, P2038, DOI 10.1074/jbc.M608144200
   Saksela M, 1998, BIOL NEONATE, V74, P274, DOI 10.1159/000014034
   Sánchez-Lozada LG, 2008, AM J PHYSIOL-RENAL, V295, pF1134, DOI 10.1152/ajprenal.00104.2008
   Sánchez-Lozada LG, 2008, AM J PHYSIOL-RENAL, V294, pF710, DOI 10.1152/ajprenal.00454.2007
   Sánchez-Lozada LG, 2008, NEPHROL DIAL TRANSPL, V23, P1179, DOI 10.1093/ndt/gfm783
   Sanchez-Lozada LG, 2007, AM J PHYSIOL-RENAL, V292, pF423, DOI 10.1152/ajprenal.00124.2006
   Sánchez-Lozada LG, 2002, AM J PHYSIOL-RENAL, V283, pF1105, DOI 10.1152/ajprenal.00170.2002
   Sánchez-Lozada LG, 2005, KIDNEY INT, V67, P237, DOI 10.1111/j.1523-1755.2005.00074.x
   Sanders SA, 1997, EUR J BIOCHEM, V245, P541, DOI 10.1111/j.1432-1033.1997.00541.x
   Sartorio A, 2007, EUR J CLIN NUTR, V61, P877, DOI 10.1038/sj.ejcn.1602588
   Sautin YY, 2007, AM J PHYSIOL-CELL PH, V293, pC584, DOI 10.1152/ajpcell.00600.2006
   Sawa T, 2000, J BIOL CHEM, V275, P32467, DOI 10.1074/jbc.M910169199
   Shah SV, 2007, J AM SOC NEPHROL, V18, P16, DOI 10.1681/ASN.2006050500
   Shankar A, 2006, J HUM HYPERTENS, V20, P937, DOI 10.1038/sj.jhh.1002095
   Shankar A, 2008, ATHEROSCLEROSIS, V196, P749, DOI 10.1016/j.atherosclerosis.2006.12.029
   Shi Y, 2003, NATURE, V425, P516, DOI 10.1038/nature01991
   Sica DA, 2000, KIDNEY, P680
   Siu YP, 2006, AM J KIDNEY DIS, V47, P51, DOI 10.1053/j.ajkd.2005.10.006
   Sobhonslidsuk A, 2007, WORLD J GASTROENTERO, V13, P3614, DOI 10.3748/wjg.v13.i26.3614
   Stirpe F, 2002, AM J GASTROENTEROL, V97, P2079
   Sturm G, 2008, EXP GERONTOL, V43, P347, DOI 10.1016/j.exger.2008.01.006
   Syrjänen J, 2000, NEPHROL DIAL TRANSPL, V15, P34, DOI 10.1093/ndt/15.1.34
   Talaat KM, 2007, AM J NEPHROL, V27, P435, DOI 10.1159/000105142
   Tanioka H, 2006, J GASTROEN HEPATOL, V21, P537, DOI 10.1111/j.1440-1746.2005.03999.x
   Tasci I, 2007, PANCREAS, V35, P366, DOI 10.1097/mpa.0b013e31806dbaaa
   Teramoto S, 2007, EUR RESPIR J, V29, P216, DOI 10.1183/09031936.00104806
   TERAMOTO S, 2007, EUR RESPIR J, V29, P217, DOI DOI 10.1183/09031936.00104806
   Videla LA, 2004, CLIN SCI, V106, P261, DOI 10.1042/CS20030285
   Wanderer AA, 2008, CLIN IMMUNOL, V128, P127, DOI 10.1016/j.clim.2008.03.514
   Wang D, 2003, J AM SOC NEPHROL, V14, P2783, DOI 10.1097/01.ASN.0000090747.59919.D2
   Ware LB, 2000, NEW ENGL J MED, V342, P1334, DOI 10.1056/NEJM200005043421806
   Waring WS, 2001, J CARDIOVASC PHARM, V38, P365, DOI 10.1097/00005344-200109000-00005
   Wright RM, 2004, AM J RESP CELL MOL, V30, P479, DOI 10.1165/rcmb.2003-0309OC
   Yamauchi M, 2008, ANTIOXID REDOX SIGN, V10, P755, DOI 10.1089/ars.2007.1946
   Yiginer O, 2008, CLIN RES CARDIOL, V97, P334, DOI 10.1007/s00392-007-0636-3
   Zhang Z, 1998, FREE RADICAL RES, V28, P151, DOI 10.3109/10715769809065801
NR 151
TC 33
Z9 36
U1 1
U2 16
PU PROUS SCIENCE, SAU-THOMSON REUTERS
PI BARCELONA
PA 398 PROVENCA, 08025 BARCELONA, SPAIN
SN 1699-3993
EI 1699-4019
J9 DRUG TODAY
JI Drugs Today
PD MAY
PY 2009
VL 45
IS 5
BP 363
EP 378
DI 10.1358/dot.2009.45.5.1377598
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 482VE
UT WOS:000268916300004
PM 19584965
DA 2025-06-11
ER

PT J
AU Jiang, QK
   Maresch, CC
   Petry, SF
   Paradowska-Dogan, A
   Bhushan, S
   Chang, YS
   Wrenzycki, C
   Schuppe, HC
   Houska, P
   Hartmann, MF
   Wudy, SA
   Shi, LB
   Linn, T
AF Jiang, Qingkui
   Maresch, Constanze C.
   Petry, Sebastian Friedrich
   Paradowska-Dogan, Agnieszka
   Bhushan, Sudhanshu
   Chang, Yongsheng
   Wrenzycki, Christine
   Schuppe, Hans-Christian
   Houska, Petr
   Hartmann, Michaela F.
   Wudy, Stefan A.
   Shi, Lanbo
   Linn, Thomas
TI Elevated CCL2 causes Leydig cell malfunction in metabolic syndrome
SO JCI INSIGHT
LA English
DT Article
ID MONOCYTE CHEMOATTRACTANT PROTEIN-1; TUMOR-NECROSIS-FACTOR; ADULT-RAT
   TESTIS; BODY-MASS INDEX; OXIDATIVE STRESS; LEPTIN-RECEPTOR;
   ADIPOSE-TISSUE; SEMEN QUALITY; FACTOR-ALPHA; OBESITY
AB Metabolic syndrome (MetS), which is associated with chronic inflammation, predisposes males to hypogonadism and subfertility. The underlying mechanism of these pathologies remains poorly understood. Homozygous leptin-resistant obese db/db mice are characterized by small testes, low testicular testosterone, and a reduced number of Leydig cells. Here we report that IL-1 beta, CCL2 (also known as MCP-1), and corticosterone concentrations were increased in the testes of db/db mice relative to those in WT controls. Cultured marine and human Leydig cells responded to cytokine stress with increased CCL2 release and apoptotic signals. Chemical inhibition of CCL2 rescued Leydig cell function in vitro and in db/db mice. Consistently, we found that CCL2-deficient mice fed with a high-energy diet were protected from testicular dysfunction compared with similarly fed WT mice. Finally, a cohort of infertile men with a history of MetS showed that reduction of CCL2 plasma levels could be achieved by weight loss and was clearly associated with recovery from hypogonadism. Taken together, we conclude that CCL2-mediated chronic inflammation is, to a large extent, responsible for the subfertility in MetS by causing damage to Leydig cells.
C1 [Jiang, Qingkui; Maresch, Constanze C.; Petry, Sebastian Friedrich; Houska, Petr; Linn, Thomas] Justus Liebig Univ JLU, Ctr Internal Med, Clin Res Unit, Giessen, Germany.
   [Paradowska-Dogan, Agnieszka] Univ Clin Bonn, Dept Gynecol Endocrinol & Reprod Med, Bonn, Germany.
   [Bhushan, Sudhanshu] JLU, Dept Reprod Biol, Inst Anat & Cell Biol, Giessen, Germany.
   [Chang, Yongsheng] Tianjin Med Univ, Dept Physiol & Pathophysiol, Tianjin Key Lab Cellular & Mol Immunol, Key Lab Immune Microenvironm & Dis,Minist Educ, Tianjin, Peoples R China.
   [Wrenzycki, Christine] JLU, Clin Vet Obstet Gynecol & Androl, Dept Mol Reprod Med, Giessen, Germany.
   [Schuppe, Hans-Christian] JLU, Dept Urol Pediat Urol & Androl, Giessen, Germany.
   [Houska, Petr] Karolinska Univ Hosp, ANOVA, Stockholm, Sweden.
   [Houska, Petr] Karolinska Inst, Stockholm, Sweden.
   [Hartmann, Michaela F.; Wudy, Stefan A.] JLU, Div Pediat Endocrinol & Diabetol, Steroid Res & Mass Spectrometry Unit, Ctr Child & Adolescent Med, Giessen, Germany.
   [Jiang, Qingkui; Shi, Lanbo] Rutgers State Univ, New Jersey Med Sch, Publ Hlth Res Inst, Rutgers Biomed & Hlth Sci, Newark, NJ USA.
C3 University of Bonn; Justus Liebig University Giessen; Tianjin Medical
   University; Ministry of Education - China; Justus Liebig University
   Giessen; Justus Liebig University Giessen; Karolinska Institutet;
   Karolinska University Hospital; Karolinska Institutet; Justus Liebig
   University Giessen; Rutgers University System; Rutgers University New
   Brunswick; Rutgers University Biomedical & Health Sciences; Rutgers
   University Newark
RP Linn, T (corresponding author), Justus Liebig Univ, Ctr Internal Med, Clin Res Unit, Klin Str 33, Giessen, Germany.
RI Wudy, Stefan/ABC-7173-2020; Petry, Sebastian/JCO-7283-2023; Jiang,
   Qingkui/AAE-1753-2022
OI Houska, Petr/0000-0003-2840-1298; Petry, Sebastian
   Friedrich/0000-0002-3496-9894; Hartmann, Michaela/0000-0001-7232-9532
FU Deutsche Forschungsgemeinschaft [DFG LI 353/17-1]; Bundesministerium fur
   Bildung und Forschung [01DL13015]
FX The authors thank Gundula Hertl, Birte Hussmann, Doris Erb, Tania Bloch,
   Kerstin Wilhelm, Franziska Kotarski, Barbara Frohlich, Ming Wang, Lei
   Zhang, and Sanjay Tyagi for expert advice and technical assistance. This
   work was supported by grants from Deutsche Forschungsgemeinschaft to TL
   (DFG LI 353/17-1) and Bundesministerium fur Bildung und Forschung to TL
   (01DL13015). The funders had no role in study design, data collection
   and analysis, decision to publish, or preparation of the manuscript. We
   acknowledge Life Science Editors and Ryan Dikdan for editing assistance.
CR Agarwal A, 2015, REPROD BIOL ENDOCRIN, V13, DOI 10.1186/s12958-015-0007-2
   Alcalá M, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-16463-6
   Aubry F, 2000, BIOL REPROD, V62, P1427, DOI 10.1095/biolreprod62.5.1427
   Azenabor Alfred, 2015, J Reprod Infertil, V16, P123
   Baccetti B, 2002, HUM REPROD, V17, P2673, DOI 10.1093/humrep/17.10.2673
   Balistreri CR, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/802078
   Barnes PJ, 1998, CLIN SCI, V94, P557, DOI 10.1042/cs0940557
   Bhatia M, 2005, AM J PHYSIOL-GASTR L, V288, pG1259, DOI 10.1152/ajpgi.00435.2004
   Bieniek JM, 2016, FERTIL STERIL, V106, P1070, DOI 10.1016/j.fertnstert.2016.06.041
   Borges BC, 2017, ENDOCRINOLOGY, V158, P2930, DOI 10.1210/en.2017-00295
   Chen HB, 2014, APOPTOSIS, V19, P1712, DOI 10.1007/s10495-014-1045-5
   Chen WQ, 2015, J VIROL, V89, P581, DOI 10.1128/JVI.02034-14
   Cherian S, 2012, AM J PHYSIOL-ENDOC M, V303, pE937, DOI 10.1152/ajpendo.00061.2012
   Christiansen T, 2005, INT J OBESITY, V29, P146, DOI 10.1038/sj.ijo.0802839
   Chua SC, 1996, SCIENCE, V271, P994, DOI 10.1126/science.271.5251.994
   Cohen P, 2001, J CLIN INVEST, V108, P1113, DOI 10.1172/JCI13914
   COLEMAN DL, 1978, DIABETOLOGIA, V14, P141, DOI 10.1007/BF00429772
   Cooper TG, 2010, HUM REPROD UPDATE, V16, P559, DOI [10.1093/humupd/dmp048, 10.1093/humupd/dmq020]
   Craig JR, 2017, FERTIL STERIL, V107, DOI 10.1016/j.fertnstert.2017.02.115
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   de Luca C, 2005, J CLIN INVEST, V115, P3484, DOI 10.1172/JCI24059
   Dohle GR, 2005, EUR UROL, V48, P703, DOI 10.1016/j.eururo.2005.06.002
   Dominy JE, 2007, AM J PHYSIOL-ENDOC M, V293, pE62, DOI 10.1152/ajpendo.00053.2007
   Du Plessis SS, 2010, NAT REV UROL, V7, P153, DOI 10.1038/nrurol.2010.6
   Evenson D, 2001, CURR PROTOC CYTOM, DOI DOI 10.1002/0471142956.CY0713S13
   Fan Y, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0120775
   Fejes I, 2005, ANDROLOGIA, V37, P155, DOI 10.1111/j.1439-0272.2005.00671.x
   Fernandez CDB, 2011, REPROD BIOL ENDOCRIN, V9, DOI 10.1186/1477-7827-9-32
   Fijak M, 2018, HUM REPROD UPDATE, V24, P416, DOI 10.1093/humupd/dmy009
   Friedman JE, 1997, J BIOL CHEM, V272, P31475, DOI 10.1074/jbc.272.50.31475
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gerald D, 2004, CELL, V118, P781, DOI 10.1016/j.cell.2004.08.025
   Gerdprasert O, 2002, MOL HUM REPROD, V8, P518, DOI 10.1093/molehr/8.6.518
   Gerendai I, 2007, AUTON NEUROSCI-BASIC, V131, P21, DOI 10.1016/j.autneu.2006.06.002
   Ghanayem BI, 2010, BIOL REPROD, V82, P96, DOI 10.1095/biolreprod.109.078915
   Guerriero G, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00056
   Hagiuda J, 2014, ANDROLOGIA, V46, P131, DOI 10.1111/and.12057
   Haidl F, 2015, ANDROLOGIA, V47, P464, DOI 10.1111/and.12408
   Harris S, 2016, TOXICOL IN VITRO, V36, P210, DOI 10.1016/j.tiv.2016.08.003
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   HUTSON JC, 1990, BIOL REPROD, V43, P885, DOI 10.1095/biolreprod43.5.885
   HUTSON JC, 1993, J REPROD IMMUNOL, V23, P63, DOI 10.1016/0165-0378(93)90027-F
   Jensen TK, 2004, FERTIL STERIL, V82, P863, DOI 10.1016/j.fertnstert.2004.03.056
   Kajihara T, 2006, MED MOL MORPHOL, V39, P203, DOI 10.1007/s00795-006-0334-7
   Kamei N, 2006, J BIOL CHEM, V281, P26602, DOI 10.1074/jbc.M601284200
   Kanda H, 2006, J CLIN INVEST, V116, P1494, DOI 10.1172/JCI26498
   Kasturi SS, 2008, J ANDROL, V29, P251, DOI 10.2164/jandrol.107.003731
   Kennedy AJ, 2010, DIS MODEL MECH, V3, P156, DOI 10.1242/dmm.003467
   Kim CS, 2006, INT J OBESITY, V30, P1347, DOI 10.1038/sj.ijo.0803259
   Kowalski TJ, 2001, DIABETES, V50, P425, DOI 10.2337/diabetes.50.2.425
   Lee B, 2011, J BIOL CHEM, V286, P29108, DOI 10.1074/jbc.M111.244905
   Luciano-Mateo F, 2019, BBA-MOL BASIS DIS, V1865, P1555, DOI 10.1016/j.bbadis.2019.03.006
   Lumeng CN, 2007, J CLIN INVEST, V117, P175, DOI 10.1172/JCI29881
   Lysiak JJ, 2003, BIOL REPROD, V69, P202, DOI 10.1095/biolreprod.102.013318
   Magnusdottir EV, 2005, HUM REPROD, V20, P208, DOI 10.1093/humrep/deh569
   Maiorino MI, 2014, DIABET METAB SYND OB, V7, P95, DOI 10.2147/DMSO.S36455
   Meinhardt A, 1998, BIOL REPROD, V59, P371, DOI 10.1095/biolreprod59.2.371
   MOORE C, 1994, ENDOCRINOLOGY, V134, P63, DOI 10.1210/en.134.1.63
   Morales V, 2003, ENDOCRINOLOGY, V144, P4763, DOI 10.1210/en.2003-0569
   Moschen AR, 2011, MOL MED, V17, P840, DOI 10.2119/molmed.2010.00108
   Nakazawa T, 2007, P NATL ACAD SCI USA, V104, P2425, DOI 10.1073/pnas.0608167104
   Nam BY, 2012, APOPTOSIS, V17, P1, DOI 10.1007/s10495-011-0661-6
   Nicolas N, 2017, SCI REP-UK, V7, DOI 10.1038/srep42391
   Nov O, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0053626
   Öztekin Ü, 2019, CUREUS J MED SCIENCE, V11, DOI 10.7759/cureus.5122
   Palmer NO, 2012, AM J PHYSIOL-ENDOC M, V302, pE768, DOI 10.1152/ajpendo.00401.2011
   Pilatz A, 2017, ANDROLOGY-US, V5, P23, DOI 10.1111/andr.12296
   Raj A, 2008, NAT METHODS, V5, P877, DOI [10.1038/nmeth.1253, 10.1038/NMETH.1253]
   REBOIS RV, 1982, J CELL BIOL, V94, P70, DOI 10.1083/jcb.94.1.70
   Reddy MM, 2006, REPROD TOXICOL, V22, P493, DOI 10.1016/j.reprotox.2006.03.003
   Saadat N, 2012, PHYSIOL GENOMICS, V44, P374, DOI 10.1152/physiolgenomics.00081.2011
   Sartipy P, 2003, P NATL ACAD SCI USA, V100, P7265, DOI 10.1073/pnas.1133870100
   Schmittgen TD, 2008, NAT PROTOC, V3, P1101, DOI 10.1038/nprot.2008.73
   Shalaby MA, 2004, PHARMACOL RES, V50, P137, DOI 10.1016/j.phrs.2003.10.013
   Sharma M, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-62272-9
   Shen H, 2006, APOPTOSIS, V11, P1049, DOI 10.1007/s10495-006-6303-8
   Shoshan-Barmatz V, 2017, CURR MED CHEM, V24, P4435, DOI 10.2174/0929867324666170616105200
   Swierczynska MM, 2015, INT J OBESITY, V39, P321, DOI 10.1038/ijo.2014.102
   Tavares RS, 2017, REPROD FERT DEVELOP, V29, P1369, DOI 10.1071/RD15475
   Tena-Sempere M, 2001, J ENDOCRINOL, V170, P413, DOI 10.1677/joe.0.1700413
   Udensi UK, 2016, J EXP CLIN CANC RES, V35, DOI 10.1186/s13046-016-0418-8
   Varga G, 2008, J LEUKOCYTE BIOL, V84, P644, DOI 10.1189/jlb.1107768
   Vermeulen A, 1996, ANN MED, V28, P13, DOI 10.3109/07853899608999068
   Wang M, 2017, J IMMUNOL, V198, P4327, DOI 10.4049/jimmunol.1700162
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Welty FK, 2016, TRANSL RES, V167, P257, DOI 10.1016/j.trsl.2015.06.017
   Wong SK, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0123-9
   Wudy SA, 2002, STEROIDS, V67, P851, DOI 10.1016/S0039-128X(02)00052-1
   Yabiku K, 2018, BMC ENDOCR DISORD, V18, DOI 10.1186/s12902-018-0266-y
   Zhu QZ, 2018, NAT REV NEPHROL, V14, P105, DOI 10.1038/nrneph.2017.157
NR 90
TC 17
Z9 18
U1 0
U2 7
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA
EI 2379-3708
J9 JCI INSIGHT
JI JCI Insight
PD NOV 5
PY 2020
VL 5
IS 21
AR e134882
DI 10.1172/jci.insight.134882
PG 20
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA OP9TN
UT WOS:000588434700003
PM 33148888
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Calligaris, SD
   Conget, P
AF Calligaris, Sebastian D.
   Conget, Paulette
TI Intravenous administration of bone marrow-derived multipotent
   mesenchymal stromal cells has a neutral effect on obesity-induced
   diabetic cardiomyopathy
SO BIOLOGICAL RESEARCH
LA English
DT Article
DE Obesity; metabolic syndrome; diabetic cardiomyopathy; multipotent
   mesenchymal stromal cells; cardiac function; dobutamine
ID PREVENTS; THERAPY; MICE
AB Obesity is a major global health issue. Obese patients develop metabolic syndrome, which is a cluster of clinical features characterized by insulin resistance and dyslipidemia. Its cardiac manifestation, diabetic cardiomyopathy, leads to heart failure.
   Bone marrow-derived multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSC) are envisioned as a therapeutic tool not only for cardiovascular diseases but also for other degenerative conditions.
   Our aim was to evaluate whether the intravenous administration of MSC modifies cardiac dysfunction in obese mice. To this end, C57BL /6 mice were fed a regular (normal) or high-fat diet (obese). Obese animals received the vehicle (obese), a single dose (obese + 1x MSC) or three doses (obese + 3x MSC) of 0.5x10(6) syngeneic MSC. Two to three months following MSC administration, cardiac function was assessed by cardiac catheterization, at basal condition and after a pharmacological stress.
   Compared to normal mice, obese mice presented hyperglycemia, hyperinsulinemia, hypercholesterolemia and cardiac dysfunction after stress condition. Exogenous MSC neither improved nor impaired this cardiac dysfunction.
   Thus, intravenous administration of MSC has neutral effect on obesity-induced diabetic cardiomyopathy.
C1 [Calligaris, Sebastian D.; Conget, Paulette] Univ Desarrollo, Inst Ciencias, Fac Med, Clin Alemana, Santiago, Chile.
C3 Universidad del Desarrollo; Clinica Alemana
RP Calligaris, SD (corresponding author), Univ Desarrollo, Inst Ciencias, Fac Med, Clin Alemana, Av Las Condes 12-438, Santiago, Chile.
EM scalligaris@udd.cl
OI Conget, Paulette/0000-0002-2530-7936; Calligaris Caprioglio, Sebastian
   Dante/0000-0002-9296-6739
FU FONDECYT [11090114]
FX This work was supported by FONDECYT grant No11090114 to SDC.
CR Abel ED, 2008, PHYSIOL REV, V88, P389, DOI 10.1152/physrev.00017.2007
   Ankrum J, 2010, TRENDS MOL MED, V16, P203, DOI 10.1016/j.molmed.2010.02.005
   [Anonymous], J VISUALIZED EXPT
   Asghar O, 2009, CLIN SCI, V116, P741, DOI 10.1042/CS20080500
   Bernardi S, 2012, EXP DIABETES RES, DOI 10.1155/2012/872504
   Bonora E, 2003, INT J OBESITY, V27, P1283, DOI 10.1038/sj.ijo.0802381
   Boudina S, 2010, REV ENDOCR METAB DIS, V11, P31, DOI 10.1007/s11154-010-9131-7
   CALLIGARIS S, 2013, PLOS ONE IN PRESS
   Conget PA, 1999, J CELL PHYSIOL, V181, P67, DOI 10.1002/(SICI)1097-4652(199910)181:1<67::AID-JCP7>3.3.CO;2-3
   Daniels A, 2010, ACTA PHYSIOL, V200, P11, DOI 10.1111/j.1748-1716.2010.02102.x
   Dominici M, 2006, CYTOTHERAPY, V8, P315, DOI 10.1080/14653240600855905
   Elnakish MT, 2012, STEM CELLS INT, V2012, DOI 10.1155/2012/646038
   Ezquer FE, 2008, BIOL BLOOD MARROW TR, V14, P631, DOI 10.1016/j.bbmt.2008.01.006
   Ezquer M, 2011, J HEPATOL, V55, P1112, DOI 10.1016/j.jhep.2011.02.020
   Haidar Yarah M, 2011, Clin Colon Rectal Surg, V24, P205, DOI 10.1055/s-0031-1295684
   Jones DA, 2012, HEART, V98, P1626, DOI 10.1136/heartjnl-2011-301540
   Kajstura J, 2001, DIABETES, V50, P1414, DOI 10.2337/diabetes.50.6.1414
   Lorenz JN, 1997, AM J PHYSIOL-HEART C, V272, pH1137, DOI 10.1152/ajpheart.1997.272.3.H1137
   Mathiasen AB, 2012, AM HEART J, V164, P285, DOI 10.1016/j.ahj.2012.05.026
   Miki T, 2013, HEART FAIL REV, V18, P149, DOI 10.1007/s10741-012-9313-3
   Obunai K, 2007, MED CLIN N AM, V91, P1169, DOI 10.1016/j.mcna.2007.06.003
   RUBLER S, 1972, AM J CARDIOL, V30, P595, DOI 10.1016/0002-9149(72)90595-4
   SAMPER E, 2012, STEM CELL REV
   Sung JH, 2008, TRANSPL P, V40, P2649, DOI 10.1016/j.transproceed.2008.08.009
   Valle-Prieto A, 2010, STEM CELLS DEV, V19, P1885, DOI 10.1089/scd.2010.0093
   Van Linthout S, 2011, CARDIOL RES PRACT, V2011, DOI 10.4061/2011/757154
   Zhang N, 2008, EXP CLIN ENDOCR DIAB, V116, P104, DOI 10.1055/s-2007-985154
NR 27
TC 10
Z9 10
U1 0
U2 3
PU SOC BIOLGIA CHILE
PI SANTIAGO
PA CASILLA 16164, SANTIAGO 9, CHILE
SN 0716-9760
EI 0717-6287
J9 BIOL RES
JI Biol. Res.
PY 2013
VL 46
IS 3
BP 251
EP 255
DI 10.4067/S0716-97602013000300005
PG 5
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA 241YR
UT WOS:000326205100005
PM 24346072
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Zhang, L
   Wu, YL
   Jia, ZH
   Zhang, Y
   Shen, HY
   Wang, XL
AF Zhang, Lin
   Wu, Yiling
   Jia, Zhenhua
   Zhang, Yun
   Shen, Hu Ying
   Wang, Xing Li
TI Protective effects of a compound herbal extract (Tong Xin Luo) on free
   fatty acid induced endothelial injury: Implications of antioxidant
   system
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE; CARDIOVASCULAR RISK-FACTOR; NITRIC-OXIDE
   PRODUCTION; METABOLIC SYNDROME; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   CELLS; APOPTOSIS; DISEASE; THIOREDOXIN
AB Background: Tong-Xin-Luo (TXL) - a mixture of herbal extracts, has been used in Chinese medicine with established therapeutic efficacy in patients with coronary artery disease.
   Methods: We investigated the protective role of TXL extracts on endothelial cells injured by a known risk factor - palmitic acid (PA), which is elevated in metabolic syndrome and associated with cardiovascular complications. Human aortic endothelial cells ( HAECs) were preconditioned with TXL extracts before exposed to PA for 24 hours.
   Results: We found that PA (0.5 mM) exposure induced 73% apoptosis in endothelial cells. However, when HAECs were preconditioned with ethanol extracted TXL ( 100 mu g/ml), PA induced only 7% of the endothelial cells into apoptosis. Using antibody-based protein microarray, we found that TXL attenuated PA-induced activation of p38-MAPK stress pathway. To investigate the mechanisms involved in TXL's protective effects, we found that TXL reduced PA-induced intracellular oxidative stress. Through AMPK pathway, TXL restored the intracellular antioxidant system, which was depressed by the PA treatment, with an increased expression of thioredoxin and a decreased expression of the thioredoxin interacting protein.
   Conclusion: In summary, our study demonstrates that TXL protects endothelial cells from PA-induced injury. This protection is likely mediated by boosting intracellular antioxidant capacity through AMPK pathway, which may account for the therapeutic efficacy in TXL-mediated cardiovascular protection.
C1 [Wu, Yiling; Jia, Zhenhua] Res Inst Integrated Tradit Chinese Med & Western, Hebei, Peoples R China.
   [Zhang, Lin; Shen, Hu Ying; Wang, Xing Li] Texas Heart Inst, Baylor Coll Med, Michael E DeBakey Dept Surg, Houston, TX 77025 USA.
   [Zhang, Yun] Shandong Univ, Qilu Hosp, Key Lab Cardiovasc Remodeling & Funct Res, Chinese Minist Educ, Jinan 250100, Peoples R China.
   [Zhang, Yun] Shandong Univ, Qilu Hosp, Key Lab Cardiovasc Remodeling & Funct Res, Chinese Minist Hlth, Jinan 250100, Peoples R China.
C3 Texas Heart Institute; Baylor College of Medicine; Shandong University;
   Ministry of Education - China; Shandong University
RP Wu, YL (corresponding author), Res Inst Integrated Tradit Chinese Med & Western, Hebei, Peoples R China.
EM linz@bcm.edu; jiatcm@163.com; jiatcm@163.com; yunzhang@sdu.edu.cn;
   hyshen@bcm.edu; xlwang@bcm.edu
RI wang, xingli/MHR-1399-2025; WU, Yuying/ISB-0204-2023
FU AHA [0565134Y, 0730190N]; NBR 973 Program of China [2005CB523301]; ICST
   [2006DFB32460]; American Heart Association (AHA) [0565134Y, 0730190N]
   Funding Source: American Heart Association (AHA)
FX This project was supported by AHA 0565134Y & 0730190N; NBR 973 Program
   of China, No. 2005CB523301, and ICST, NO. 2006DFB32460).
CR Arad M, 2007, CIRC RES, V100, P474, DOI 10.1161/01.RES.0000258446.23525.37
   Araki M, 1999, J BIOL CHEM, V274, P2271, DOI 10.1074/jbc.274.4.2271
   BABIOR BM, 1973, J CLIN INVEST, V52, P741, DOI 10.1172/JCI107236
   Best PJM, 1999, ARTERIOSCL THROM VAS, V19, P14, DOI 10.1161/01.ATV.19.1.14
   Boden G, 2003, EXP CLIN ENDOCR DIAB, V111, P121, DOI 10.1055/s-2003-39781
   Boden G, 1997, DIABETES, V46, P3, DOI 10.2337/diabetes.46.1.3
   Bombeli T, 1997, BLOOD, V89, P2429, DOI 10.1182/blood.V89.7.2429
   Brechtel K, 2001, MAGNET RESON MED, V45, P179, DOI 10.1002/1522-2594(200102)45:2<179::AID-MRM1023>3.0.CO;2-D
   Calingasan NY, 1998, AM J PATHOL, V153, P599, DOI 10.1016/S0002-9440(10)65602-7
   Carlsson M, 2000, ARTERIOSCL THROM VAS, V20, P1588, DOI 10.1161/01.ATV.20.6.1588
   Dichtl W, 1999, CIRC RES, V84, P1085, DOI 10.1161/01.RES.84.9.1085
   Dimmeler S, 1998, EUR CYTOKINE NETW, V9, P697
   Dimmeler S, 1997, CIRC RES, V81, P970
   Egan BM, 1999, PROSTAG LEUKOTR ESS, V60, P411, DOI 10.1016/S0952-3278(99)80022-2
   Fryer LGD, 2002, BIOCHEM J, V363, P167, DOI 10.1042/0264-6021:3630167
   GRANGER DN, 1981, GASTROENTEROLOGY, V81, P22
   Grundy SM, 2007, J CLIN ENDOCR METAB, V92, P399, DOI 10.1210/jc.2006-0513
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Guo WX, 2008, ARCH MED RES, V39, P434, DOI 10.1016/j.arcmed.2008.02.001
   Haunstetter A, 1998, CIRC RES, V82, P1111, DOI 10.1161/01.RES.82.11.1111
   HurtCamejo E, 1997, ARTERIOSCL THROM VAS, V17, P300, DOI 10.1161/01.ATV.17.2.300
   Ide N, 1999, DRUG DEV IND PHARM, V25, P619, DOI 10.1081/DDC-100102217
   Jouven X, 2001, CIRCULATION, V104, P756, DOI 10.1161/hc3201.094151
   Kaimul AM, 2007, FREE RADICAL BIO MED, V43, P861, DOI 10.1016/j.freeradbiomed.2007.05.032
   Keaney JF, 1996, J CLIN INVEST, V98, P386, DOI 10.1172/JCI118804
   Kim F, 2005, ARTERIOSCL THROM VAS, V25, P989, DOI 10.1161/01.ATV.0000160549.60980.a8
   Li DY, 1998, AM J PHYSIOL-HEART C, V275, pH568, DOI 10.1152/ajpheart.1998.275.2.H568
   Lillig CH, 2007, ANTIOXID REDOX SIGN, V9, P25, DOI 10.1089/ars.2007.9.25
   Long YC, 2006, J CLIN INVEST, V116, P1776, DOI 10.1172/JCI29044
   MARUI N, 1993, J CLIN INVEST, V92, P1866, DOI 10.1172/JCI116778
   McGarry JD, 2002, DIABETES, V51, P7, DOI 10.2337/diabetes.51.1.7
   Meydani M, 1999, MECH AGEING DEV, V111, P123, DOI 10.1016/S0047-6374(99)00067-6
   Moellering D, 1999, FREE RADICAL BIO MED, V26, P1138, DOI 10.1016/S0891-5849(98)00300-1
   MOSLEN MT, 1994, ADV EXP MED BIOL, V366, P17
   Patwari P, 2007, AM J PATHOL, V170, P805, DOI 10.2353/ajpath.2007.061243
   Patwari P, 2006, J BIOL CHEM, V281, P21884, DOI 10.1074/jbc.M600427200
   Qian HY, 2007, CHINESE MED J-PEKING, V120, P1416, DOI 10.1097/00029330-200708020-00008
   Shen YH, 2006, J BIOL CHEM, V281, P7727, DOI 10.1074/jbc.M511105200
   Staiger H, 2004, DIABETES, V53, P3209, DOI 10.2337/diabetes.53.12.3209
   Steinberg HO, 1997, J CLIN INVEST, V100, P1230, DOI 10.1172/JCI119636
   Steinberg HO, 2000, DIABETES, V49, P1231, DOI 10.2337/diabetes.49.7.1231
   Stentz FB, 2006, BIOCHEM BIOPH RES CO, V346, P721, DOI 10.1016/j.bbrc.2006.05.159
   Wu TX, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004474.pub2
   Tripathy D, 2003, DIABETES, V52, P2882, DOI 10.2337/diabetes.52.12.2882
   Uwaifo GI, 2003, AM J MED, V115, P12, DOI 10.1016/j.amjmed.2003.08.009
   Wang XL, 2006, DIABETES, V55, P2301, DOI 10.2337/db05-1574
   World CJ, 2006, J MOL MED-JMM, V84, P997, DOI 10.1007/s00109-006-0109-6
   Wyne KL, 2003, AM J MED, V115, P29, DOI 10.1016/j.amjmed.2003.09.004
NR 48
TC 19
Z9 23
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD JUL 14
PY 2008
VL 8
AR 39
DI 10.1186/1472-6882-8-39
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 398QK
UT WOS:000262746400001
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, J
   Sun, RY
   Cai, Y
   Peng, B
   Yang, X
   Gao, KM
AF Zhang, Jian
   Sun, Rongyi
   Cai, Yang
   Peng, Bo
   Yang, Xi
   Gao, Keming
TI Efficacy and Safety of Antidiabetic Agents for Major Depressive Disorder
   and Bipolar Depression: A Meta-Analysis of Randomized, Double-Blind,
   Placebo-Controlled Trials
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE bipolar disorder; depression; antidiabetic; meta-analysis
ID TRANSCRANIAL MAGNETIC STIMULATION; STAR-ASTERISK-D; PIOGLITAZONE
   ADJUNCTIVE THERAPY; TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE;
   2ND-GENERATION ANTIPSYCHOTICS; COGNITIVE DYSFUNCTION; INTRANASAL
   INSULIN; METABOLIC SYNDROME; RESIDUAL SYMPTOMS
AB Background: This meta-analysis aimed to determine the efficacy and safety of antidiabetic agents in the treatment of major depressive disorder and bipolar depression. Methods: Randomized controlled trials (RCTs) of antidiabetic agents in major depressive disorder or bipolar depression were searched in three electronic databases and three clinical trial registry websites from their inception up to October 2023. The differences in changes in the depression rating scale scores from baseline to endpoint or pre-defined sessions, response rate, remission rate, rate of side effects and dropout rate between antidiabetic agents and placebo were meta-analyzed. Results: Six RCTs involving 399 participants were included in the final meta-analysis, which did not find that antidiabetics outperformed the placebo in reducing depressive symptoms. The standardized mean difference (SMD) in the depression scores from baseline to endpoint was 0.25 (95% CI -0.1, 0.61). However, a subgroup analysis found a significant difference between antidiabetics and placebos in reducing depressive symptoms in Middle Eastern populations, with an SMD of 0.89 (95% CI 0.44, 1.34). Conclusions: The current meta-analysis does not support the efficacy of antidiabetics being superior to the placebo in the treatment of unipolar and bipolar depression. However, a subgroup analysis indicates that patients from the Middle East may benefit from adding an antidiabetic medication to their ongoing medication(s) for their depression. Larger studies with good-quality study designs are warranted.
C1 [Zhang, Jian; Peng, Bo; Yang, Xi] Shenzhen Kangning Hosp, Shenzhen Mental Hlth Ctr, Shenzhen 518020, Peoples R China.
   [Zhang, Jian; Gao, Keming] Univ Hosp Cleveland Med Ctr, Dept Psychiat, Mood Disorders Program, 10524 Euclid Ave,12th Floor, Cleveland, OH 44106 USA.
   [Sun, Rongyi; Cai, Yang; Gao, Keming] Case Western Reserve Univ, Sch Med, Dept Psychiat, Cleveland, OH 44106 USA.
C3 Shenzhen Institute of Mental Health & Shenzhen Kangning Hospital;
   University Hospitals of Cleveland; University System of Ohio; Case
   Western Reserve University
RP Gao, KM (corresponding author), Univ Hosp Cleveland Med Ctr, Dept Psychiat, Mood Disorders Program, 10524 Euclid Ave,12th Floor, Cleveland, OH 44106 USA.; Gao, KM (corresponding author), Case Western Reserve Univ, Sch Med, Dept Psychiat, Cleveland, OH 44106 USA.
EM zhjjjjjj@126.com; keming.gao@uhhospitals.org
FU Shenzhen Key Medical Discipline Construction Fund
FX No Statement Available
CR Abdallah MS, 2020, NEUROTHERAPEUTICS, V17, P1897, DOI 10.1007/s13311-020-00878-7
   Adriaanse MC, 2006, DIABETOLOGIA, V49, P2874, DOI 10.1007/s00125-006-0500-4
   Aftab A, 2019, J AFFECT DISORDERS, V245, P957, DOI 10.1016/j.jad.2018.11.090
   Aftab A, 2017, EXPERT OPIN DRUG DIS, V12, P1067, DOI 10.1080/17460441.2017.1354849
   Ali S, 2006, DIABETIC MED, V23, P1165, DOI 10.1111/j.1464-5491.2006.01943.x
   Avery DH, 2008, J CLIN PSYCHIAT, V69, P441, DOI 10.4088/JCP.v69n0315
   Azizi F, 2019, LANCET DIABETES ENDO, V7, P866, DOI 10.1016/S2213-8587(19)30179-2
   Bahji A, 2021, CAN J PSYCHIAT, V66, P274, DOI 10.1177/0706743720970857
   Bai YH, 2020, J CLIN PSYCHOPHARM, V40, P167, DOI 10.1097/JCP.0000000000001169
   Bartoli F, 2021, J PSYCHIATR RES, V143, P230, DOI 10.1016/j.jpsychires.2021.09.018
   Bell CN, 2019, PREV MED, V119, P1, DOI 10.1016/j.ypmed.2018.11.024
   Berk M, 2019, JAMA-J AM MED ASSOC, V321, P842, DOI 10.1001/jama.2019.0273
   Beurel E, 2020, NEURON, V107, P234, DOI 10.1016/j.neuron.2020.06.002
   Beyer JL, 2016, PSYCHIAT CLIN N AM, V39, P75, DOI 10.1016/j.psc.2015.10.003
   Bharath LP, 2020, CELL METAB, V32, P44, DOI 10.1016/j.cmet.2020.04.015
   Bo QJ, 2019, PSYCHIAT CLIN NEUROS, V73, P70, DOI 10.1111/pcn.12797
   Brouwer A, 2021, J AFFECT DISORDERS, V295, P1371, DOI 10.1016/j.jad.2021.08.151
   Calkin CV, 2022, J CLIN PSYCHIAT, V83, DOI 10.4088/JCP.21m14022
   Calkin CV, 2019, ANN MED, V51, P281, DOI 10.1080/07853890.2019.1659511
   Calkin CV, 2015, BRIT J PSYCHIAT, V206, P52, DOI 10.1192/bjp.bp.114.152850
   Carter J, 2016, PSYCHONEUROENDOCRINO, V69, P123, DOI 10.1016/j.psyneuen.2016.04.002
   Cha DS, 2017, J AFFECT DISORDERS, V210, P57, DOI 10.1016/j.jad.2016.12.006
   Chen J, 2011, CURR OPIN PSYCHIATR, V24, P10, DOI 10.1097/YCO.0b013e3283413505
   Chen XD, 2024, AM J GERIAT PSYCHIAT, V32, P117, DOI 10.1016/j.jagp.2023.08.010
   Ciarambino T, 2011, NUTRITION, V27, P46, DOI 10.1016/j.nut.2009.10.017
   Colle R, 2017, NEUROPSYCH DIS TREAT, V13, P9, DOI 10.2147/NDT.S121149
   Conradi HJ, 2011, PSYCHOL MED, V41, P1165, DOI 10.1017/S0033291710001911
   Cooper H, 2019, The handbook of research synthesis and metaanalysis
   Cuperfain AB, 2020, NEUROSCI BIOBEHAV R, V111, P125, DOI 10.1016/j.neubiorev.2020.01.022
   de Groot M, 2001, PSYCHOSOM MED, V63, P619, DOI 10.1097/00006842-200107000-00015
   Dipnall JF, 2015, J AFFECT DISORDERS, V174, P215, DOI 10.1016/j.jad.2014.11.030
   Ehrmann D, 2017, ACTA DIABETOL, V54, P749, DOI 10.1007/s00592-017-1006-x
   Fabbri C, 2021, PROG NEURO-PSYCHOPH, V104, DOI 10.1016/j.pnpbp.2020.110050
   Fava M, 2006, J PSYCHOPHARMACOL, V20, P29, DOI 10.1177/1359786806064325
   Fava M, 2018, WORLD PSYCHIATRY, V17, P28, DOI 10.1002/wps.20481
   Fedgchin M, 2019, INT J NEUROPSYCHOPH, V22, P616, DOI 10.1093/ijnp/pyz039
   Fernandes BS, 2022, NEUROSCI BIOBEHAV R, V139, DOI 10.1016/j.neubiorev.2022.104758
   Ferrari AJ, 2022, LANCET PSYCHIAT, V9, P137, DOI 10.1016/S2215-0366(21)00395-3
   Ferrari AJ, 2016, BIPOLAR DISORD, V18, P440, DOI 10.1111/bdi.12423
   Frangou S, 2019, EXP NEUROL, V316, P20, DOI 10.1016/j.expneurol.2019.04.001
   Gao KM, 2016, J CLIN PSYCHOPHARM, V36, P637, DOI 10.1097/JCP.0000000000000596
   Gao KM, 2015, NEUROSCI BULL, V31, P572, DOI 10.1007/s12264-014-1534-0
   García-Toro M, 2016, J AFFECT DISORDERS, V194, P105, DOI 10.1016/j.jad.2015.12.064
   Geddes JR, 2009, BRIT J PSYCHIAT, V194, P4, DOI 10.1192/bjp.bp.107.048504
   George MS, 2010, EXPERT REV NEUROTHER, V10, P1761, DOI 10.1586/ERN.10.95
   Goes FS, 2023, BMJ-BRIT MED J, V381, DOI 10.1136/bmj-2022-073591
   Grigolon RB, 2019, PROG NEURO-PSYCHOPH, V95, DOI 10.1016/j.pnpbp.2019.109720
   Gruber J, 2023, NEUROSCI BIOBEHAV R, V149, DOI 10.1016/j.neubiorev.2023.105179
   Hamer JA, 2019, EXP NEUROL, V315, P1, DOI 10.1016/j.expneurol.2019.01.016
   Higgins J, 2011, Cochrane handbook for systematic reviews of interventionsM
   Higgins JPT, 2003, BMJ-BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557
   Hojlund M, 2022, WORLD PSYCHIATRY, V21, P444, DOI 10.1002/wps.21010
   Huang MH, 2022, PSYCHIAT CLIN NEUROS, V76, P450, DOI 10.1111/pcn.13433
   Huang YF, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-260
   Itsiopoulos C, 2022, CURR OPIN CLIN NUTR, V25, P415, DOI 10.1097/MCO.0000000000000872
   Kan C, 2013, DIABETES CARE, V36, P480, DOI 10.2337/dc12-1442
   Kashani L, 2013, PSYCHONEUROENDOCRINO, V38, P767, DOI 10.1016/j.psyneuen.2012.08.010
   Kelly T, 2019, BIPOLAR DISORD, V21, P302, DOI 10.1111/bdi.12753
   Kemp DE, 2014, CNS DRUGS, V28, P571, DOI 10.1007/s40263-014-0158-2
   Kemp DE, 2012, J AFFECT DISORDERS, V136, P1164, DOI 10.1016/j.jad.2011.06.033
   Khaledi M, 2019, ACTA DIABETOL, V56, P631, DOI 10.1007/s00592-019-01295-9
   Knight A, 2015, BMC GERIATR, V15, DOI 10.1186/s12877-015-0054-8
   Kofod J, 2022, EUR NEUROPSYCHOPHARM, V54, P116, DOI 10.1016/j.euroneuro.2021.09.006
   Konstantinou G, 2022, BIPOLAR DISORD, V24, P10, DOI 10.1111/bdi.13099
   Lassale C, 2019, MOL PSYCHIATR, V24, P965, DOI 10.1038/s41380-018-0237-8
   Leonard BE, 2020, ACTA NEUROPSYCHIATR, V32, P1, DOI 10.1017/neu.2019.17
   Lesser IM, 2007, MED CARE, V45, P1043, DOI 10.1097/MLR.0b013e3181271462
   Levkovitz Y, 2015, WORLD PSYCHIATRY, V14, P64, DOI 10.1002/wps.20199
   Lin KW, 2015, PSYCHIAT RES, V230, P846, DOI 10.1016/j.psychres.2015.10.013
   Liu YK, 2022, J AFFECT DISORDERS, V300, P449, DOI 10.1016/j.jad.2021.12.110
   MacQueen GM, 2017, PSYCHIAT CLIN NEUROS, V71, P18, DOI 10.1111/pcn.12463
   Maina JG, 2023, DIABETES CARE, V46, DOI 10.2337/dc22-2373
   Malesza IJ, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10113164
   Malhi GS, 2018, LANCET, V392, P2299, DOI 10.1016/S0140-6736(18)31948-2
   Mansur RB, 2021, J PSYCHIATR RES, V133, P82, DOI 10.1016/j.jpsychires.2020.12.007
   Mansur RB, 2017, EUR NEUROPSYCHOPHARM, V27, P1153, DOI 10.1016/j.euroneuro.2017.08.433
   Mansur RB, 2014, NEUROMOL MED, V16, P658, DOI 10.1007/s12017-014-8316-8
   McClintock SM, 2011, J CLIN PSYCHOPHARM, V31, P180, DOI 10.1097/JCP.0b013e31820ebd2c
   McGrath PJ, 2006, AM J PSYCHIAT, V163, P1531, DOI 10.1176/appi.ajp.163.9.1531
   McIntyre RS, 2012, BIPOLAR DISORD, V14, P697, DOI 10.1111/bdi.12006
   Mommersteeg PMC, 2013, DIABETIC MED, V30, pE208, DOI 10.1111/dme.12193
   Moulton CD, 2015, LANCET DIABETES ENDO, V3, P461, DOI 10.1016/S2213-8587(15)00134-5
   Murphy E, 2013, NEUROPSYCHOPHARMACOL, V38, P2598, DOI 10.1038/npp.2013.166
   Murrough JW, 2011, NEUROBIOL LEARN MEM, V96, P553, DOI 10.1016/j.nlm.2011.06.006
   Nibber A, 2022, J AFFECT DISORDERS, V310, P52, DOI 10.1016/j.jad.2022.04.156
   Nierenberg AA, 2010, PSYCHOL MED, V40, P41, DOI 10.1017/S0033291709006011
   Nierenberg AA, 2006, AM J PSYCHIAT, V163, P210, DOI 10.1176/appi.ajp.163.2.210
   O'Reardon JP, 2007, BIOL PSYCHIAT, V62, P1208, DOI 10.1016/j.biopsych.2007.01.018
   Ochs-Ross R, 2020, AM J GERIAT PSYCHIAT, V28, P121, DOI 10.1016/j.jagp.2019.10.008
   Pan A, 2008, J AFFECT DISORDERS, V109, P75, DOI 10.1016/j.jad.2007.11.002
   Patrick J.L., 2013, Adding an Insulin-Sensitizing Medication to Depression Treatment for People Who Are Depressed and Overweight
   Perera T, 2016, BRAIN STIMUL, V9, P336, DOI 10.1016/j.brs.2016.03.010
   Phillips JL, 2019, AM J PSYCHIAT, V176, P401, DOI 10.1176/appi.ajp.2018.18070834
   Pigott HE, 2023, BMJ OPEN, V13, DOI 10.1136/bmjopen-2022-063095
   Popova V, 2019, AM J PSYCHIAT, V176, P428, DOI 10.1176/appi.ajp.2019.19020172
   Rasgon N, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2015.187
   Rasgon NL, 2010, THESCIENTIFICWORLDJO, V10, P321, DOI 10.1100/tsw.2010.32
   Rashidian H, 2023, J PSYCHOPHARMACOL, V37, P313, DOI 10.1177/02698811221132473
   Robinson LJ, 2006, J AFFECT DISORDERS, V93, P105, DOI 10.1016/j.jad.2006.02.016
   Rush AJ, 2006, AM J PSYCHIAT, V163, P1905, DOI 10.1176/appi.ajp.163.11.1905
   Rush AJ, 2006, NEW ENGL J MED, V354, P1231, DOI 10.1056/NEJMoa052963
   Sadeghi O, 2021, NUTR NEUROSCI, V24, P248, DOI 10.1080/1028415X.2019.1620425
   Semenkovich K, 2015, DRUGS, V75, P577, DOI 10.1007/s40265-015-0347-4
   Sepanjnia K, 2012, NEUROPSYCHOPHARMACOL, V37, P2093, DOI 10.1038/npp.2012.58
   Shariq AS, 2018, PROG NEURO-PSYCHOPH, V83, P86, DOI 10.1016/j.pnpbp.2018.01.003
   Shi HQ, 2022, BRAIN BEHAV IMMUN, V106, P100, DOI 10.1016/j.bbi.2022.07.165
   Shomaker LB, 2018, CONTEMP CLIN TRIALS, V75, P19, DOI 10.1016/j.cct.2018.10.007
   Staudt MD, 2019, FRONT NEUROSCI-SWITZ, V13, DOI 10.3389/fnins.2019.00108
   Steardo L, 2019, J AFFECT DISORDERS, V245, P174, DOI 10.1016/j.jad.2018.10.360
   Tabák AG, 2014, LANCET DIABETES ENDO, V2, P236, DOI 10.1016/S2213-8587(13)70139-6
   Trivedi MH, 2006, J CLIN PSYCHIAT, V67, P27
   Trivedi MH, 2006, AM J PSYCHIAT, V163, P28, DOI 10.1176/appi.ajp.163.1.28
   Trivedi MH, 2006, NEW ENGL J MED, V354, P1243, DOI 10.1056/NEJMoa052964
   Vancampfort D, 2015, J CLIN PSYCHIAT, V76, P1490, DOI 10.4088/JCP.14r09635
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Watson KT, 2021, JAMA PSYCHIAT, V78, P439, DOI 10.1001/jamapsychiatry.2020.3669
   Wilson MM, 2016, J ACAD NUTR DIET, V116, P302, DOI 10.1016/j.jand.2015.09.020
   Zeinoddini A, 2015, DEPRESS ANXIETY, V32, P167, DOI 10.1002/da.22340
   ,, 2008, The global burden of disease: 2004 update
NR 119
TC 4
Z9 4
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD FEB
PY 2024
VL 13
IS 4
AR 1172
DI 10.3390/jcm13041172
PG 24
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA JI3C6
UT WOS:001172487200001
PM 38398483
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kwon, J
   Kim, DY
   Cho, KJ
   Hashimoto, M
   Matsuoka, K
   Kamijo, T
   Wang, Z
   Karnup, S
   Robertson, AM
   Tyagi, P
   Yoshimura, N
AF Kwon, Joonbeom
   Kim, Duk Yoon
   Cho, Kang Jun
   Hashimoto, Mamoru
   Matsuoka, Kanako
   Kamijo, Tadanobu
   Wang, Zhou
   Karnup, Sergei
   Robertson, Anne M.
   Tyagi, Pradeep
   Yoshimura, Naoki
TI Pathophysiology of Overactive Bladder and Pharmacologic Treatments
   Including j33-Adrenoceptor Agonists -Basic Research Perspectives-
SO INTERNATIONAL NEUROUROLOGY JOURNAL
LA English
DT Article
DE Overactive bladder; Pathophysiology; j33-Adrenergic receptors;
   j33-Agonists
ID URINARY-TRACT SYMPTOMS; NERVE GROWTH-FACTOR; MESSENGER-RNA EXPRESSION;
   DETRUSOR SMOOTH-MUSCLE; BENIGN PROSTATIC HYPERPLASIA; 3RD
   NATIONAL-HEALTH; BOTULINUM-TOXIN-A; BETA(3)-ADRENOCEPTOR AGONIST; OUTLET
   OBSTRUCTION; AFFERENT ACTIVITY
AB Overactive bladder (OAB) is a symptom-based syndrome defined by urinary urgency, frequency, and nocturia with or without urge incontinence. The causative pathology is diverse; including bladder outlet obstruction (BOO), bladder ischemia, aging, metabolic syndrome, psychological stress, affective disorder, urinary microbiome, localized and systemic inflammatory responses, etc. Several hypotheses have been suggested as mechanisms of OAB generation; among them, neurogenic, myogenic, and urothelial mechanisms are well-known hypotheses. Also, a series of local signals called autonomous myogenic contraction, micromotion, or afferent noises, which can occur during bladder filling, may be induced by the leak of acetylcholine (ACh) or urothelial release of adenosine triphosphate (ATP). They can be transmitted to the central nervous system through afferent fibers to trigger coordinated urgency-related detrusor contractions. Antimuscarinics, commonly known to induce smooth muscle relaxation by competitive blockage of muscarinic receptors in the parasympathetic postganglionic nerve, have a minimal effect on detrusor contraction within therapeutic doses. In fact, they have a predominant role in preventing signals in the afferent nerve transmission process. j33-adrenergic receptor (AR) agonists inhibit afferent signals by predominant inhibition of mechanosensitive A delta-fibers in the normal bladder. However, in pathologic conditions such as spinal cord injury, it seems to inhibit capsaicin-sensitive C-fibers. Particularly, mirabegron, a j33-agonist, prevents ACh release in the BOO-induced detrusor overactivity model by parasympathetic prejunctional mechanisms. A recent study also revealed that vibegron may have 2 mechanisms of action: inhibition of ACh from cholinergic efferent nerves in the detrusor and afferent inhibition via urothelial j33-AR.
C1 [Kwon, Joonbeom; Cho, Kang Jun; Hashimoto, Mamoru; Matsuoka, Kanako; Kamijo, Tadanobu; Wang, Zhou; Tyagi, Pradeep; Yoshimura, Naoki] Univ Pittsburgh, Sch Med, Dept Urol, Suite 700,Kaufmann Med Bldg,3471 Fifth Ave, Pittsburgh, PA 15213 USA.
   [Kwon, Joonbeom] Leaders Urol Clin, Daegu, South Korea.
   [Kim, Duk Yoon] Catholic Univ Daegu, Sch Med, Dept Urol, Daegu, South Korea.
   [Cho, Kang Jun] Catholic Univ Korea, Coll Med, Dept Urol, Seoul, South Korea.
   [Karnup, Sergei; Yoshimura, Naoki] Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15213 USA.
   [Robertson, Anne M.] Univ Pittsburgh, Sch Bioengn, Dept Mech Engn & Mat Sci, Pittsburgh, PA 15213 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Catholic University of Daegu; Catholic University of
   Korea; Pennsylvania Commonwealth System of Higher Education (PCSHE);
   University of Pittsburgh; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh
RP Yoshimura, N (corresponding author), Univ Pittsburgh, Sch Med, Dept Urol, Suite 700,Kaufmann Med Bldg,3471 Fifth Ave, Pittsburgh, PA 15213 USA.
EM nyos@pitt.edu
RI Cho, Kang Jun/GXF-3772-2022; Kim, Young-Il/ISS-7678-2023
FU National Institutes of Health [R01 DK129194, R01 DK133434, R01 DK134580]
FX The research work by authors has been supported by grants from the
   National Institutes of Health (R01 DK129194 to NY and SK; R01 DK133434
   to AMR and NY; R01 DK134580 to ZW & NY) .
CR Abrams P, 2002, NEUROUROL URODYNAM, V21, P167, DOI 10.1002/nau.10052
   ABRAMS PH, 1979, J UROLOGY, V121, P640, DOI 10.1016/S0022-5347(17)56918-9
   Aizawa N, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-07898-y
   Aizawa N, 2012, EUR UROL, V62, P1165, DOI 10.1016/j.eururo.2012.08.056
   Aizawa N, 2010, NEUROUROL URODYNAM, V29, P771, DOI 10.1002/nau.20826
   ALBANESE A, 1988, NEUROSCI LETT, V87, P46, DOI 10.1016/0304-3940(88)90143-7
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Andersson KE, 2017, INT NEUROUROL J, V21, P6, DOI 10.5213/inj.1734850.425
   Andersson KE, 2013, CURR UROL REP, V14, P435, DOI 10.1007/s11934-013-0335-8
   Andersson KE, 2011, EUR UROL, V59, P377, DOI 10.1016/j.eururo.2010.11.040
   Andersson KE, 2009, CURR OPIN UROL, V19, P380, DOI 10.1097/MOU.0b013e32832ce8a4
   Andersson KE, 2004, PHYSIOL REV, V84, P935, DOI 10.1152/physrev.00038.2003
   Andersson KE, 2003, DRUGS, V63, P2595, DOI 10.2165/00003495-200363230-00003
   Andersson KE, 2004, LANCET NEUROL, V3, P46, DOI 10.1016/S1474-4422(03)00622-7
   Andersson KE, 2003, EUR UROL, V43, P1, DOI 10.1016/S0302-2838(02)00540-7
   Andersson KE, 2002, UROLOGY, V59, P43, DOI 10.1016/S0090-4295(01)01637-5
   Apostolidis A, 2005, J UROLOGY, V174, P977, DOI 10.1097/01.ju.0000169481.42259.54
   Azadzoi KM, 2011, J UROLOGY, V186, P2115, DOI 10.1016/j.juro.2011.06.047
   Azadzoi KM, 2010, J UROLOGY, V183, P362, DOI 10.1016/j.juro.2009.08.103
   Azadzoi KM, 2003, J UROLOGY, V169, P1885, DOI 10.1097/01.ju.0000048668.97821.f4
   Baker SA, 2008, BRIT J PHARMACOL, V153, P1259, DOI 10.1038/sj.bjp.0707690
   Baker SA, 2010, J UROLOGY, V183, P793, DOI 10.1016/j.juro.2009.09.079
   Bayrak S, 2015, N-S ARCH PHARMACOL, V388, P761, DOI 10.1007/s00210-014-1060-7
   Biallosterski BT, 2011, J UROLOGY, V186, P721, DOI 10.1016/j.juro.2011.03.123
   Birder LA, 2002, NAT NEUROSCI, V5, P856, DOI 10.1038/nn902
   Birder L, 2013, PHYSIOL REV, V93, P653, DOI 10.1152/physrev.00030.2012
   Birder LA, 2007, NAT CLIN PRACT UROL, V4, P46, DOI 10.1038/ncpuro0672
   Birder LA, 2014, NEUROUROL URODYNAM, V33, P597, DOI 10.1002/nau.22604
   Brading AF, 2003, ADV EXP MED BIOL, V539, P255
   Brading AF, 1997, UROLOGY, V50, P57, DOI 10.1016/S0090-4295(97)00591-8
   Braverman AS, 2003, AM J PHYSIOL-REG I, V285, pR701, DOI 10.1152/ajpregu.00009.2003
   Bschleipfer T, 2007, LIFE SCI, V80, P2303, DOI 10.1016/j.lfs.2007.01.053
   Bunn F, 2015, INT J CLIN PRACT, V69, P199, DOI 10.1111/ijcp.12518
   Chancellor MB, 2008, NAT CLIN PRACT UROL, V5, P319, DOI 10.1038/ncpuro1124
   Cheng FZ, 2022, J MECH BEHAV BIOMED, V134, DOI 10.1016/j.jmbbm.2022.105337
   Cheng JT, 2007, NEUROSCI LETT, V423, P1, DOI 10.1016/j.neulet.2007.05.062
   Chess-Williams R, 2021, LUTS, V13, P414, DOI 10.1111/luts.12395
   Chuang YC, 2001, J UROLOGY, V165, P975, DOI 10.1016/S0022-5347(05)66587-1
   Claustre Y, 2008, NEUROSCIENCE, V156, P353, DOI 10.1016/j.neuroscience.2008.07.011
   Clemow DB, 1998, AM J PHYSIOL-REG I, V275, pR1279, DOI 10.1152/ajpregu.1998.275.4.R1279
   Cockayne DA, 2000, NATURE, V407, P1011, DOI 10.1038/35039519
   Coelho A, 2017, NEUROUROL URODYNAM, V36, P1972, DOI 10.1002/nau.23224
   Compérat E, 2006, EUR UROL, V50, P1058, DOI 10.1016/j.eururo.2006.01.025
   Contreras-Sanz A, 2016, AM J PHYSIOL-RENAL, V311, pF805, DOI 10.1152/ajprenal.00339.2015
   Cook SP, 2000, NATURE, V407, P951, DOI 10.1038/35039648
   D'Agostino G, 2015, EUR J PHARMACOL, V758, P115, DOI 10.1016/j.ejphar.2015.03.074
   Das A, 1996, J Spinal Cord Med, V19, P190
   de Groat WC, 2004, UROLOGY, V64, P7, DOI 10.1016/j.urology.2004.08.063
   de Groat WC, 1997, UROLOGY, V50, P36, DOI 10.1016/S0090-4295(97)00587-6
   de Groat WC, 2010, NEUROUROL URODYNAM, V29, P63, DOI 10.1002/nau.20761
   De Laet K, 2006, NEUROUROL URODYNAM, V25, P156, DOI 10.1002/nau.20208
   DEGROAT WC, 1990, J AUTONOM NERV SYST, V30, pS71, DOI 10.1016/0165-1838(90)90105-R
   DEGROAT WC, 1981, J AUTONOM NERV SYST, V3, P135, DOI 10.1016/0165-1838(81)90059-X
   DEGROAT WC, 1975, BRAIN RES, V87, P201, DOI 10.1016/0006-8993(75)90417-5
   Deruyver Y, 2015, BJU INT, V115, P686, DOI 10.1111/bju.12876
   Di Meo S, 2001, BIOL SIGNAL RECEPT, V10, P125
   Dmitrieva N, 1997, NEUROSCIENCE, V78, P449, DOI 10.1016/S0306-4522(96)00575-1
   Drake MJ, 2017, NEUROUROL URODYNAM, V36, P850, DOI 10.1002/nau.23006
   Drake MJ, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0170726
   Drake MJ, 2017, BJU INT, V119, P22, DOI 10.1111/bju.13598
   Drake MJ, 2003, J UROLOGY, V170, P276, DOI 10.1097/01.ju.0000069722.35137.e0
   Drake MJ, 2001, LANCET, V358, P401, DOI 10.1016/S0140-6736(01)05549-0
   DRAY A, 1995, BRIT J ANAESTH, V75, P125, DOI 10.1093/bja/75.2.125
   Eastham J, 2015, N-S ARCH PHARMACOL, V388, P695, DOI 10.1007/s00210-015-1122-5
   Elman I, 2016, NEURON, V89, P11, DOI 10.1016/j.neuron.2015.11.027
   Filippi S, 2007, ENDOCRINOLOGY, V148, P1019, DOI 10.1210/en.2006-1079
   Finney SM, 2006, BJU INT, V98, P503, DOI 10.1111/j.1464-410X.2006.06258.x
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Fovaeus M, 1999, J UROLOGY, V161, P649, DOI 10.1016/S0022-5347(01)61988-8
   Fowler CJ, 2008, NAT REV NEUROSCI, V9, P453, DOI 10.1038/nrn2401
   Freeman RS, 2004, PROG BRAIN RES, V146, P111, DOI 10.1016/S0079-6123(03)46008-1
   Frias B, 2012, BJU INT, V110, pE422, DOI 10.1111/j.1464-410X.2012.11187.x
   Fujimura T, 1999, J UROLOGY, V161, P680, DOI 10.1016/S0022-5347(01)61994-3
   Funahashi Y, 2019, J PHYSIOL-LONDON, V597, P2063, DOI 10.1113/JP277452
   Fung TC, 2017, NAT NEUROSCI, V20, P145, DOI 10.1038/nn.4476
   Furuta A, 2020, N-S ARCH PHARMACOL, V393, P2073, DOI 10.1007/s00210-020-01921-2
   Fusco F, 2018, BMC UROL, V18, DOI 10.1186/s12894-018-0329-4
   GEIRSSON G, 1995, J UROLOGY, V154, P1825, DOI 10.1016/S0022-5347(01)66793-4
   GERMAN K, 1995, J UROLOGY, V153, P1678, DOI 10.1016/S0022-5347(01)67503-7
   Gill K, 2021, BMC UROL, V21, DOI 10.1186/s12894-021-00809-4
   Gillespie JI, 2012, BJU INT, V110, pE132, DOI 10.1111/j.1464-410X.2012.11240.x
   Gillespie JI, 2009, BJU INT, V103, P1324, DOI 10.1111/j.1464-410X.2009.08377.x
   Gillespie JI, 2004, BJU INT, V93, P478, DOI 10.1111/j.1464-410X.2003.04667.x
   Gotoh D, 2020, NEUROUROL URODYNAM, V39, P2120, DOI 10.1002/nau.24486
   Griffiths D, 2005, J UROLOGY, V174, P1862, DOI 10.1097/01.ju.0000177450.34451.97
   Griffiths D, 2008, NEUROUROL URODYNAM, V27, P466, DOI 10.1002/nau.20549
   Grundy L, 2020, AM J PHYSIOL-RENAL, V318, pF298, DOI 10.1152/ajprenal.00435.2019
   HABLER HJ, 1990, J PHYSIOL-LONDON, V425, P545
   Hanna-Mitchell AT, 2014, J ENDOCRINOL, V222, P113, DOI 10.1530/JOE-13-0422
   Hashim H, 2006, J UROLOGY, V175, P191, DOI 10.1016/S0022-5347(05)00067-4
   Hashimoto M, 2024, NEUROUROL URODYNAM, V43, P267, DOI 10.1002/nau.25323
   Hawthorn MH, 2000, BRIT J PHARMACOL, V129, P416, DOI 10.1038/sj.bjp.0703068
   He Q, 2016, PROSTATE CANCER P D, V19, P7, DOI 10.1038/pcan.2015.43
   Herman JP, 2008, PROG BRAIN RES, V170, P353, DOI 10.1016/S0079-6123(08)00429-9
   Herrera GM, 2003, J PHYSIOL-LONDON, V551, P893, DOI 10.1113/jphysiol.2003.045914
   Hicks A, 2007, J PHARMACOL EXP THER, V323, P202, DOI 10.1124/jpet.107.125757
   Hodo TW, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.01869
   HOLSTEGE G, 1986, J COMP NEUROL, V250, P449, DOI 10.1002/cne.902500404
   Housami Fadi, 2008, Curr Urol Rep, V9, P284, DOI 10.1007/s11934-008-0050-z
   Hsiao SM, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-64532-0
   Hughes FM, 2019, AM J PHYSIOL-RENAL, V316, pF113, DOI 10.1152/ajprenal.00400.2018
   Hughes FM, 2016, J UROLOGY, V195, P1598, DOI 10.1016/j.juro.2015.12.068
   HYPOLITE JA, 1993, MOL CELL BIOCHEM, V125, P35, DOI 10.1007/BF00926832
   Igarashi T, 2021, PROSTATE, V81, P1303, DOI 10.1002/pros.24227
   Igawa Y, 2019, BRIT J PHARMACOL, V176, P2525, DOI 10.1111/bph.14658
   Ikeda Y, 2008, AM J PHYSIOL-RENAL, V295, pF454, DOI 10.1152/ajprenal.90315.2008
   Inamura S, 2017, PROSTATE, V77, P794, DOI 10.1002/pros.23319
   Irwin DE, 2006, EUR UROL, V50, P1306, DOI 10.1016/j.eururo.2006.09.019
   Jiang YH, 2016, J UROLOGY, V196, P831, DOI 10.1016/j.juro.2016.02.2958
   Johnson JD, 2005, NEUROSCIENCE, V135, P1295, DOI 10.1016/j.neuroscience.2005.06.090
   Joseph S, 2022, CURR THER RES CLIN E, V96, DOI 10.1016/j.curtheres.2022.100669
   Kadekawa K, 2017, AM J PHYSIOL-RENAL, V313, pF796, DOI 10.1152/ajprenal.00097.2017
   Kai W, 2020, MOL MED REP, V22, P219, DOI 10.3892/mmr.2020.11092
   Kaiho Y, 2008, BJU INT, V101, P615, DOI 10.1111/j.1464-410X.2007.07307.x
   Kalantaridou SN, 2010, J REPROD IMMUNOL, V85, P33, DOI 10.1016/j.jri.2010.02.005
   Kanai A, 2012, NEUROUROL URODYNAM, V31, P300, DOI 10.1002/nau.21246
   Kaneko Y, 2014, BRIT J PHARMACOL, V171, P2474, DOI 10.1111/bph.12414
   Kanno T, 2010, J CELL PHYSIOL, V224, P345, DOI 10.1002/jcp.22114
   Kershen RT, 2002, J UROLOGY, V168, P121, DOI 10.1016/S0022-5347(05)64843-4
   Kessler TM, 2008, EUR UROL, V53, P607, DOI 10.1016/j.eururo.2007.07.015
   Kim JC, 2004, BJU INT, V94, P915, DOI 10.1111/j.1464-4096.2003.05059.x
   Kim JC, 2008, BJU INT, V101, P371, DOI 10.1111/j.1464-410X.2007.07251.x
   Kita M, 2010, AM J PHYSIOL-REG I, V298, pR1310, DOI 10.1152/ajpregu.00523.2009
   Klausner Adam P, 2004, J Urol, V172, P2570, DOI 10.1097/01.ju.0000144142.26242.f3
   Komninos C, 2014, CUAJ-CAN UROL ASSOC, V8, pE524, DOI 10.5489/cuaj.1636
   Kraneveld AD, 2014, BASIC CLIN PHARMACOL, V114, P128, DOI 10.1111/bcpt.12154
   Krichevsky VP, 1999, J UROLOGY, V161, P1644, DOI 10.1016/S0022-5347(05)68997-5
   Kullmann FA, 2011, NEUROUROL URODYNAM, V30, P144, DOI 10.1002/nau.20965
   Kushida N, 2016, BJU INT, V117, P982, DOI 10.1111/bju.13240
   Kwon J, 2022, NEUROUROL URODYNAM, V41, P1355, DOI 10.1002/nau.24956
   Larauche M, 2008, AM J PHYSIOL-GASTR L, V294, pG1033, DOI 10.1152/ajpgi.00507.2007
   Lawrence JM, 2007, DIABETES CARE, V30, P2536, DOI 10.2337/dc07-0262
   Lee WC, 2009, JTUA, V20, P155
   Lee WC, 2011, J UROLOGY, V186, P318, DOI 10.1016/j.juro.2011.03.037
   Liu RT, 2011, UROLOGY, V78, P1040, DOI 10.1016/j.urology.2011.05.017
   Maggi CA, 1993, Nervous Control ofthe Urogenital System, V3, P383
   MALLORY B, 1989, AM J PHYSIOL, V257, pR410, DOI 10.1152/ajpregu.1989.257.2.R410
   Mansfield KJ, 2022, FRONT PHYSIOL, V13, DOI 10.3389/fphys.2022.886782
   Marsland AL, 2017, BRAIN BEHAV IMMUN, V64, P208, DOI 10.1016/j.bbi.2017.01.011
   McVary KT, 2007, J UROLOGY, V177, P1401, DOI 10.1016/j.juro.2006.11.037
   McVary KT, 2007, J UROLOGY, V177, P1071, DOI 10.1016/j.juro.2006.10.055
   Meredith AL, 2004, J BIOL CHEM, V279, P36746, DOI 10.1074/jbc.M405621200
   Michel MC, 2011, PHARMACOL THERAPEUT, V131, P40, DOI 10.1016/j.pharmthera.2011.03.014
   Mills IW, 2000, J UROLOGY, V163, P646, DOI 10.1016/S0022-5347(05)67951-7
   Mills KA, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-97053-5
   Mills KA, 2020, ARCH TOXICOL, V94, P2785, DOI 10.1007/s00204-020-02773-8
   Milsom I, 2001, BJU INT, V87, P760, DOI 10.1046/j.1464-410x.2001.02228.x
   Moon S, 2022, INT NEUROUROL J, V26, P144, DOI 10.5213/inj.2142370.185
   Moon S, 2021, NEUROUROL URODYNAM, V40, P1569, DOI 10.1002/nau.24711
   Moro C, 2011, UROLOGY, V78, DOI 10.1016/j.urology.2011.08.039
   NEMETH CJ, 1977, INVEST UROL, V15, P149
   Ni JS, 2019, PROSTATE, V79, P872, DOI 10.1002/pros.23794
   Nickel JC, 2008, EUR UROL, V54, P1379, DOI 10.1016/j.eururo.2007.11.026
   Niemczyk G, 2020, BIOMED RES INT, V2020, DOI 10.1155/2020/6632359
   Nirmal J, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0102644
   Nishiguchi J, 2007, BJU INT, V99, P680, DOI 10.1111/j.1464-410X.2006.06643.x
   Nitti VW, 2013, J UROLOGY, V190, P1320, DOI 10.1016/j.juro.2013.05.062
   Nobe K, 2008, J PHARMACOL EXP THER, V324, P631, DOI 10.1124/jpet.107.131334
   Nomiya M, 2003, J UROLOGY, V170, P649, DOI 10.1097/01.ju.0000067621.62736.7c
   O'Reilly BA, 2002, J UROLOGY, V167, P157, DOI 10.1016/S0022-5347(05)65403-1
   Pacák K, 2000, PHYSIOL RES, V49, pS11
   Pascal LE, 2021, ENDOCRINOLOGY, V162, DOI 10.1210/endocr/bqaa212
   Pearce MM, 2014, MBIO, V5, DOI 10.1128/mBio.01283-14
   Petkov GV, 2001, J PHYSIOL-LONDON, V537, P443, DOI 10.1111/j.1469-7793.2001.00443.x
   PRICE DA, 1980, BRIT J UROL, V52, P529, DOI 10.1111/j.1464-410X.1980.tb03107.x
   Ressler KJ, 2000, DEPRESS ANXIETY, V12, P2, DOI 10.1002/1520-6394(2000)12:1+<2::AID-DA2>3.3.CO;2-W
   RESTORICK JM, 1989, BRIT J UROL, V63, P32, DOI 10.1111/j.1464-410X.1989.tb05120.x
   Reynolds WS, 2016, NAT REV UROL, V13, P481, DOI 10.1038/nrurol.2016.95
   RODRIGUEZ M, 1995, MOL BRAIN RES, V29, P369, DOI 10.1016/0169-328X(94)00274-I
   Rohrmann S, 2004, UROLOGY, V64, P504, DOI 10.1016/j.urology.2004.04.012
   Rouget C, 2014, PHARMACOL RES, V80, P14, DOI 10.1016/j.phrs.2013.12.006
   Salkoff L, 2006, NAT REV NEUROSCI, V7, P921, DOI 10.1038/nrn1992
   Sawada N, 2013, EUR UROL, V64, P664, DOI 10.1016/j.eururo.2013.06.043
   Schulte-Baukloh H, 2013, UROLOGY, V81, P1052, DOI 10.1016/j.urology.2012.12.021
   Shen JD, 2021, BIOLOGY-BASEL, V10, DOI 10.3390/biology10121316
   Shimizu T, 2021, INT J UROL, V28, P1093, DOI 10.1111/iju.14663
   Sibley GNA, 1997, BRIT J UROL, V80, P54
   SIBLEY GNA, 1984, J PHYSIOL-LONDON, V354, P431, DOI 10.1113/jphysiol.1984.sp015386
   Sigala S, 2002, UROLOGY, V60, P719, DOI 10.1016/S0090-4295(02)01819-8
   Silva I, 2017, AM J PHYSIOL-RENAL, V313, pF388, DOI 10.1152/ajprenal.00392.2016
   Somogyi GT, 1998, BRIT J PHARMACOL, V125, P241, DOI 10.1038/sj.bjp.0702041
   STAMM WE, 1982, NEW ENGL J MED, V307, P463, DOI 10.1056/NEJM198208193070802
   STEERS WD, 1991, J CLIN INVEST, V88, P1709, DOI 10.1172/JCI115488
   Steers WD, 2007, BJU INT, V100, P337, DOI 10.1111/j.1464-410X.2007.06980.x
   Steers William D, 2002, Rev Urol, V4 Suppl 4, pS7
   Stevens LA, 2007, EUR UROL, V52, P531, DOI 10.1016/j.eururo.2006.11.016
   Stewart WF, 2002, WORLD J UROL, V20, P327, DOI 10.1007/s00345-002-0301-4
   Stief CG, 2008, EUR UROL, V53, P1236, DOI 10.1016/j.eururo.2008.01.075
   Stothers Lynn, 2003, Can J Urol, V10, P1971
   Sui G, 2009, CELL CALCIUM, V45, P456, DOI 10.1016/j.ceca.2009.03.001
   SUMMERS RJ, 1995, BRIT J PHARMACOL, V116, P2547, DOI 10.1111/j.1476-5381.1995.tb17205.x
   Svalo J, 2013, EUR J PHARMACOL, V699, P101, DOI 10.1016/j.ejphar.2012.11.060
   Tadic SD, 2012, NEUROUROL URODYNAM, V31, P652, DOI 10.1002/nau.21240
   Takahashi N, 2009, NEUROUROL URODYNAM, V28, P257, DOI 10.1002/nau.20625
   Takasu T, 2007, J PHARMACOL EXP THER, V321, P642, DOI 10.1124/jpet.106.115840
   Takeda H, 2002, NEUROUROL URODYNAM, V21, P558, DOI 10.1002/nau.10034
   Tamburella A, 2010, EUR NEUROPSYCHOPHARM, V20, P704, DOI 10.1016/j.euroneuro.2010.04.006
   Tanyeri P, 2013, PHARMACOL BIOCHEM BE, V110, P27, DOI 10.1016/j.pbb.2013.05.017
   Thomas-White KJ, 2016, INT UROGYNECOL J, V27, P723, DOI 10.1007/s00192-015-2847-x
   Tong YC, 2007, J UROLOGY, V178, P1537, DOI 10.1016/j.juro.2007.05.114
   Tong YC, 2006, NEUROSCI LETT, V406, P216, DOI 10.1016/j.neulet.2006.07.065
   Truss MC, 1996, NEUROUROL URODYNAM, V15, P59, DOI 10.1002/(SICI)1520-6777(1996)15:1<59::AID-NAU6>3.0.CO;2-E
   Turner WH, 1997, PHARMACOL THERAPEUT, V75, P77, DOI 10.1016/S0163-7258(97)00038-7
   Tyagi P, 2010, INT UROL NEPHROL, V42, P629, DOI 10.1007/s11255-009-9647-5
   Uchida H, 2005, EUR J PHARMACOL, V518, P195, DOI 10.1016/j.ejphar.2005.06.029
   Ullmann E, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21207440
   Ulrich-Lai YM, 2009, NAT REV NEUROSCI, V10, P397, DOI 10.1038/nrn2647
   Van Os-Bossagh P, 2001, INT UROGYNECOL J PEL, V12, P89, DOI 10.1007/s001920170071
   Vizzard MA, 2000, EXP NEUROL, V161, P273, DOI 10.1006/exnr.1999.7254
   Vrijens D, 2015, J PSYCHOSOM RES, V78, P95, DOI 10.1016/j.jpsychores.2014.11.019
   Wang XS, 2020, INFLAMMOPHARMACOLOGY, V28, P63, DOI 10.1007/s10787-019-00651-z
   West EG, 2021, LIFE SCI, V265, DOI 10.1016/j.lfs.2020.118735
   Wróbel A, 2017, EUR J PHARMACOL, V812, P216, DOI 10.1016/j.ejphar.2017.07.010
   Wu P, 2017, FRONT CELL INFECT MI, V7, DOI 10.3389/fcimb.2017.00488
   Yang JH, 2020, RES REP UROL, V12, P391, DOI 10.2147/RRU.S271618
   Yang SSD, 2002, J UROLOGY, V168, P571, DOI 10.1016/S0022-5347(05)64682-4
   Yokoyama Osamu, 1997, American Journal of Physiology, V273, pR1900
   Yoshida M, 2010, NEUROUROL URODYNAM, V29, P1350, DOI 10.1002/nau.20843
   YOSHIMURA N, 1993, NEUROPHARMACOLOGY, V32, P315, DOI 10.1016/0028-3908(93)90151-R
   Yoshimura N, 2007, NEUROUROL URODYNAM, V26, P908, DOI 10.1002/nau.20487
   Yu HJ, 2006, UROL INT, V77, P327, DOI 10.1159/000096337
   Zhang X, 2018, BRAIN BEHAV IMMUN, V73, P520, DOI 10.1016/j.bbi.2018.06.017
   Zhao ZH, 2016, INVESTIG CLIN UROL, V57, P249, DOI 10.4111/icu.2016.57.4.249
   Zhong Y, 2003, NEUROSCIENCE, V120, P667, DOI 10.1016/S0306-4522(03)00243-4
NR 225
TC 4
Z9 4
U1 2
U2 5
PU KOREAN CONTINENCE SOC
PI YEONGOTONG-GU
PA DEPT UROLOGY, AJOU UNIV COLL MEDICINE, SAN 5 WONCHEN-DONG,
   YEONGOTONG-GU, SUWON 443-721, SOUTH KOREA
SN 2093-4777
EI 2093-6931
J9 INT NEUROUROL J
JI Int. Neurourol. J.
PD FEB
PY 2024
VL 28
SU 1
BP S12
EP S33
DI 10.5213/inj.2448002.001
PG 22
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA KK0E2
UT WOS:001179728400005
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wilson, PB
   Bohjanen, KA
   Ingraham, SJ
   Leon, AS
AF Wilson, P. B.
   Bohjanen, K. A.
   Ingraham, S. J.
   Leon, A. S.
TI Psoriasis and physical activity: a review
SO JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
LA English
DT Review
ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; OXIDATIVE STRESS BIOMARKERS;
   ADHESION MOLECULES ICAM-1; LOW-DENSITY-LIPOPROTEIN;
   NECROSIS-FACTOR-ALPHA; MIDDLE-AGED MEN; QUALITY-OF-LIFE; METABOLIC
   SYNDROME; RISK-FACTORS
AB Psoriasis is a common, chronic inflammatory skin disease that can cause significant discomfort and impairment to quality of life. Recent research indicates that individuals with moderate-to-severe psoriasis are likely at greater risk for chronic cardiometabolic co-morbidities such as cardiovascular disease, type 2 diabetes, obesity and metabolic syndrome. Physical activity can be an effective primary and adjunctive treatment for these maladies in other populations. Unfortunately, only a limited number of studies have examined physical activity in psoriasis, which are limited by poor design and lack of validated physical activity assessment methodologies. A variety of data suggest shared physiologic pathways between physical activity, psoriasis, and psoriasis cardiometabolic co-morbidities. Increased adiposity, inflammation, oxidative stress, adhesion molecules and lipids are physiologically linked to psoriasis, the risk of psoriasis cardiometabolic co-morbidities, and low levels of physical activity. In addition, epigenetic pathways are involved in psoriasis and could be influenced by physical activity. The physical and psychosocial impairments common in psoriasis may make it difficult to participate in regular physical activity, and future studies should aim to determine if physical activity interventions improve functioning and reduce co-morbidities in psoriasis.
C1 [Wilson, P. B.; Ingraham, S. J.; Leon, A. S.] Univ Minnesota, Sch Kinesiol, Minneapolis, MN USA.
   [Bohjanen, K. A.] Univ Minnesota, Dept Dermatol, Minneapolis, MN 55455 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities
RP Wilson, PB (corresponding author), Univ Minnesota, Sch Kinesiol, Minneapolis, MN USA.
EM wilso733@umn.edu
CR Al-Mazeedi K, 2006, INT J DERMATOL, V45, P418, DOI 10.1111/j.1365-4632.2006.02502.x
   Anderson JW, 2001, AM J CLIN NUTR, V74, P579
   [Anonymous], J EUR ACAD DERMATOL
   [Anonymous], HERZ
   [Anonymous], J EUR ACAD DERMATOL
   [Anonymous], 2000, COCHRANE DB SYST REV
   [Anonymous], BR J DIA VASC DIS
   Azfar RS, 2008, CURR OPIN RHEUMATOL, V20, P416, DOI 10.1097/BOR.0b013e3283031c99
   Bonora E, 2003, INT J OBESITY, V27, P1283, DOI 10.1038/sj.ijo.0802381
   Bouassida A, 2010, BRIT J SPORT MED, V44, P620, DOI 10.1136/bjsm.2008.046151
   Cabrijan L, 2009, MED HYPOTHESES, V72, P327, DOI 10.1016/j.mehy.2008.06.049
   Campbell PT, 2010, MED SCI SPORT EXER, V42, P1448, DOI 10.1249/MSS.0b013e3181cfc908
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Çerman AA, 2008, BRIT J DERMATOL, V159, P820, DOI 10.1111/j.1365-2133.2008.08742.x
   Chen YJ, 2008, ARCH DERMATOL, V144, P1571, DOI 10.1001/archderm.144.12.1571
   Chodorowska G, 2004, J EUR ACAD DERMATOL, V18, P180, DOI 10.1111/j.1468-3083.2004.00863.x
   Christensen DP, 2011, MOL MED, V17, P378, DOI 10.2119/molmed.2011.00021
   Churilla JR, 2008, AM J LIFESTYLE MED, V2, P118, DOI 10.1177/1559827607311981
   Cohen AD, 2008, J EUR ACAD DERMATOL, V22, P585, DOI 10.1111/j.1468-3083.2008.02636.x
   Coimbra S, 2010, J EUR ACAD DERMATOL, V24, P1386, DOI 10.1111/j.1468-3083.2010.03647.x
   Coimbra S, 2010, J EUR ACAD DERMATOL, V24, P789, DOI 10.1111/j.1468-3083.2009.03527.x
   Covas MI, 2002, MED SCI SPORT EXER, V34, P814, DOI 10.1097/00005768-200205000-00014
   Danesh J, 2008, PLOS MED, V5, P600, DOI 10.1371/journal.pmed.0050078
   Devaraj S, 2010, CURR ATHEROSCLER REP, V12, P110, DOI 10.1007/s11883-010-0098-3
   Dubertret L, 2006, BRIT J DERMATOL, V155, P729, DOI 10.1111/j.1365-2133.2006.07405.x
   El Barnawi NY, 2001, BRIT J BIOMED SCI, V58, P40
   Elosua R, 2003, ATHEROSCLEROSIS, V167, P327, DOI 10.1016/S0021-9150(03)00018-2
   Ettinger JEMTM, 2006, OBES SURG, V16, P94
   Fantuzzi G, 2005, J ALLERGY CLIN IMMUN, V115, P911, DOI 10.1016/j.jaci.2005.02.023
   Farber EM, 1997, CUTIS, V59, P35
   Fogelholm M, 2006, EUR J SPORT SCI, V6, P15, DOI 10.1080/17461390600563085
   Friedewald VE, 2008, AM J CARDIOL, V102, P1631, DOI 10.1016/j.amjcard.2008.10.004
   Gaesser Glenn A, 2007, Curr Diab Rep, V7, P14, DOI 10.1007/s11892-007-0004-8
   Gelfand JM, 2006, JAMA-J AM MED ASSOC, V296, P1735, DOI 10.1001/jama.296.14.1735
   Gisondi P, 2007, BRIT J DERMATOL, V157, P68, DOI 10.1111/j.1365-2133.2007.07986.x
   Gisondi P, 2008, AM J CLIN NUTR, V88, P1242, DOI 10.3945/ajcn.2008.26427
   Goldberg AD, 2007, CELL, V128, P635, DOI 10.1016/j.cell.2007.02.006
   Goldhammer E, 2005, INT J CARDIOL, V100, P93, DOI 10.1016/j.ijcard.2004.08.073
   Hajer GR, 2008, EUR HEART J, V29, P2959, DOI 10.1093/eurheartj/ehn387
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Hay RMA, 2011, EXP DERMATOL, V20, P715, DOI 10.1111/j.1600-0625.2011.01299.x
   Herron MD, 2005, ARCH DERMATOL, V141, P1527, DOI 10.1001/archderm.141.12.1527
   Higa-Sansone G, 2004, OBES SURG, V14, P1132, DOI 10.1381/0960892041975569
   Hollander J, 2001, PFLUG ARCH EUR J PHY, V442, P426, DOI 10.1007/s004240100539
   Holvoet P, 2001, ARTERIOSCL THROM VAS, V21, P844, DOI 10.1161/01.ATV.21.5.844
   Holvoet P, 2008, JAMA-J AM MED ASSOC, V299, P2287, DOI 10.1001/jama.299.19.2287
   HORROCKS C, 1991, CLIN EXP IMMUNOL, V84, P157
   Jacobsson LTH, 2005, J RHEUMATOL, V32, P1213
   Jenner Nicole, 2002, Australas J Dermatol, V43, P255, DOI 10.1046/j.1440-0960.2002.00611.x
   Karolkiewicz J, 2003, Aging Male, V6, P100, DOI 10.1080/713604768
   Kaur S, 2011, J EUR ACAD DERMATOL, V25, P1328, DOI 10.1111/j.1468-3083.2011.03982.x
   KAVLI G, 1985, BMJ-BRIT MED J, V291, P999, DOI 10.1136/bmj.291.6501.999
   Keylock KT, 2008, AM J PHYSIOL-REG I, V294, pR179, DOI 10.1152/ajpregu.00177.2007
   Knowler William C, 2002, N Engl J Med, V346, P393, DOI 10.1056/NEJMoa012512
   Koo J, 1996, DERMATOL CLIN, V14, P485, DOI 10.1016/S0733-8635(05)70376-4
   Kostka T, 2000, CLIN PHYSIOL, V20, P185
   Kristiansen OP, 2005, DIABETES, V54, pS114, DOI 10.2337/diabetes.54.suppl_2.S114
   Krötz F, 2005, J AM COLL CARDIOL, V45, P1700, DOI 10.1016/j.jacc.2005.02.039
   Kural BV, 2003, CLIN CHIM ACTA, V328, P71, DOI 10.1016/S0009-8981(02)00373-X
   Lambert J, 2011, ARCH DERMATOL RES, V303, P57, DOI 10.1007/s00403-010-1082-z
   LEIBOWITZ E, 1991, BRIT J DERMATOL, V124, P439, DOI 10.1111/j.1365-2133.1991.tb00622.x
   Leon AS, 2009, AM J LIFESTYLE MED, V3, p32S, DOI 10.1177/1559827609332348
   Leon AS, 2005, CIRCULATION, V111, P369, DOI 10.1161/01.CIR.0000151788.08740.5C
   Li S, 2009, P NATL ACAD SCI USA, V106, P4349, DOI 10.1073/pnas.0810844106
   Luc G, 2003, ATHEROSCLEROSIS, V170, P169, DOI 10.1016/S0021-9150(03)00280-6
   Mallbris L, 2006, J AM ACAD DERMATOL, V54, P614, DOI 10.1016/j.jaad.2005.11.1079
   Manjula V D, 2011, Indian J Dermatol, V56, P403, DOI 10.4103/0019-5154.84767
   McLaren JE, 2009, CYTOKINE GROWTH F R, V20, P125, DOI 10.1016/j.cytogfr.2008.11.003
   Melnikova I, 2009, NAT REV DRUG DISCOV, V8, P767, DOI 10.1038/nrd2996
   Michigan A, 2011, MOL DIAGN THER, V15, P265, DOI 10.2165/11593400-000000000-00000
   Mizutani H, 1997, J DERMATOL SCI, V14, P145, DOI 10.1016/S0923-1811(96)00562-2
   Nakajima K, 2010, INT J SPORTS MED, V31, P671, DOI 10.1055/s-0029-1246140
   Neimann AL., 2006, EXPERT REV DERMATOL, V1, P63, DOI [DOI 10.1586/17469872.1.1.63, 10.1586/17469872.1.1.63]
   Neimann AL, 2006, J AM ACAD DERMATOL, V55, P829, DOI 10.1016/j.jaad.2006.08.040
   Nisa N, 2010, INDIAN J DERMATOL VE, V76, P662, DOI 10.4103/0378-6323.72462
   Osmancevic A, 2008, ACTA DERM-VENEREOL, V88, P240, DOI 10.2340/00015555-0403
   Ouchi N, 2003, CURR OPIN LIPIDOL, V14, P561, DOI 10.1097/00041433-200312000-00003
   Prizment AE, 2011, CANCER CAUSE CONTROL, V22, P1003, DOI 10.1007/s10552-011-9773-0
   Qureshi AA, 2010, ARCH DERMATOL, V146, P1364, DOI 10.1001/archdermatol.2010.204
   RAMSAY B, 1988, BRIT J DERMATOL, V118, P195, DOI 10.1111/j.1365-2133.1988.tb01774.x
   Raychaudhuri SP, 2000, CUTIS, V66, P348
   Ruchusatsawat K, 2006, J MOL MED, V84, P175, DOI 10.1007/s00109-005-0020-6
   Sattar N, 2009, J AM COLL CARDIOL, V53, P167, DOI 10.1016/j.jacc.2008.09.035
   Schmidt C, 2009, ANGIOLOGY, V60, P108, DOI 10.1177/0003319708316899
   Setty AR, 2007, ARCH INTERN MED, V167, P1670, DOI 10.1001/archinte.167.15.1670
   Shapiro J, 2007, J AM ACAD DERMATOL, V56, P629, DOI 10.1016/j.jaad.2006.09.017
   Shih M, 2006, AM J PREV MED, V30, P385, DOI 10.1016/j.amepre.2005.12.005
   Shirinsky IV, 2007, J AM ACAD DERMATOL, V57, P529, DOI 10.1016/j.jaad.2007.05.040
   Sommer DM, 2006, ARCH DERMATOL RES, V298, P321, DOI 10.1007/s00403-006-0703-z
   Stofkova A, 2009, Endocr Regul, V43, P157
   Straczkowski M, 2001, EUR J ENDOCRINOL, V145, P273, DOI 10.1530/eje.0.1450273
   Strickland FM, 2008, AUTOIMMUNITY, V41, P278, DOI 10.1080/08916930802024616
   Szegedi A, 2003, IMMUNOL LETT, V86, P277, DOI 10.1016/S0165-2478(03)00025-7
   Takahashi H, 2008, BRIT J DERMATOL, V159, P1207, DOI 10.1111/j.1365-2133.2008.08823.x
   Tate DF, 2007, AM J CLIN NUTR, V85, P954, DOI 10.1093/ajcn/85.4.954
   Taxman DJ, 2006, J IMMUNOL, V177, P4252, DOI 10.4049/jimmunol.177.7.4252
   Tekin NS, 2007, MEDIAT INFLAMM, V2007, DOI 10.1155/2007/78454
   Thomas DR, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002968.pub2
   Thompson D, 2010, J APPL PHYSIOL, V108, P769, DOI 10.1152/japplphysiol.00822.2009
   Tobin AM, 2010, J RHEUMATOL, V37, P1386, DOI 10.3899/jrheum.090822
   Tonjes Anke, 2007, Diabetes Care, V30, pe1, DOI 10.2337/dc06-1760
   Tovar-Castillo LE, 2007, INT J DERMATOL, V46, P239, DOI 10.1111/j.1365-4632.2006.02962.x
   Treloar V, 2010, CLIN DERMATOL, V28, P93, DOI 10.1016/j.clindermatol.2009.03.016
   Tsukui S, 2000, INT J OBESITY, V24, P1207, DOI 10.1038/sj.ijo.0801373
   Turesson C, 2007, CURR OPIN RHEUMATOL, V19, P190, DOI 10.1097/BOR.0b013e3280147107
   Vasankari TJ, 1998, MED SCI SPORT EXER, V30, P1496, DOI 10.1097/00005768-199810000-00005
   Vuorimaa T, 2005, INT J SPORTS MED, V26, P420, DOI 10.1055/s-2004-821142
   WOLF AM, 1994, INT J EPIDEMIOL, V23, P991, DOI 10.1093/ije/23.5.991
   Yang AL, 2003, ATHEROSCLEROSIS, V169, P11, DOI 10.1016/S0021-9150(03)00013-3
   Zalewska A, 2006, MEDIAT INFLAMM, V2006, DOI 10.1155/MI/2006/81797
   Zhang FF, 2011, EPIGENETICS-US, V6, P293, DOI 10.4161/epi.6.3.14378
   Zhou BD, 2011, CARDIOVASC RES, V90, P413, DOI 10.1093/cvr/cvr003
   Zhou Q, 2009, FREE RADICAL BIO MED, V47, P891, DOI 10.1016/j.freeradbiomed.2009.06.033
   Zoppini G, 2006, NUTR METAB CARDIOVAS, V16, P543, DOI 10.1016/j.numecd.2005.09.004
NR 114
TC 40
Z9 44
U1 0
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0926-9959
EI 1468-3083
J9 J EUR ACAD DERMATOL
JI J. Eur. Acad. Dermatol. Venereol.
PD NOV
PY 2012
VL 26
IS 11
BP 1345
EP 1353
DI 10.1111/j.1468-3083.2012.04494.x
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 026JD
UT WOS:000310271000002
PM 22385402
DA 2025-06-11
ER

PT J
AU Meng, Y
   Eirin, A
   Zhu, XY
   Tang, H
   Chanana, P
   Lerman, A
   van Wijnen, AJ
   Lerman, LO
AF Meng, Yu
   Eirin, Alfonso
   Zhu, Xiang-Yang
   Tang, Hui
   Chanana, Pritha
   Lerman, Amir
   van Wijnen, Andre J.
   Lerman, Lilach O.
TI Obesity-induced mitochondrial dysfunction in porcine adipose
   tissue-derived mesenchymal stem cells
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Article
DE mesenchymal stem cells; metabolic syndrome; mitochondria; obesity
ID BONE-MARROW; METABOLIC SYNDROME; STROMAL CELLS; SELF-RENEWAL;
   DIFFERENTIATION; MICRORNA; EXPRESSION; PLASTICITY; APOPTOSIS; INJURY
AB Transplantation of autologous mesenchymal stem cells (MSCs) may be a viable option for treatment of several diseases. MSCs efficacy depends on adequate function of their mitochondria, which might be impaired in a noxious milieu. We hypothesized that obesity compromises MSCs mitochondrial structure and function, possibly via micro-RNA (miRNA)-based mechanisms. MSCs were collected from swine abdominal adipose tissue after 16 weeks of Lean or Obese diet (n=7 each). Mitochondrial structure was assessed by electron microscopy and function by membrane potential and cytochrome-c oxidase (COX)-IV activity. Oxidative stress was assessed by Mito-SOX and dihydroethidium staining. Next-generation sequencing (RNA-seq) was performed to identify miRNAs expression in MSCs, and predicted mitochondrial target genes were then identified (MitoCarta). Compared to Lean-MSCs, mitochondria from Obese-MSCs were smaller and showed cristae remodeling and loss. Mitochondrial membrane potential and COX-IV activity decreased in Obese-MSCs, associated with increased mitochondrial oxidative stress. RNA-seq generated reads for 413 miRNAs, of which 5 miRNAs were upregulated in Obese-MSCs (fold change >2, p<0.05) and found to target 43 specific mitochondrial genes. Obesity impairs MSC mitochondrial structure and function, possibly mediated partly through miRNA-induced mitochondrial gene regulation, leading to increased oxidative stress. Importantly, these alterations may limit the therapeutic use of autologous MSCs in subjects with obesity.
C1 [Meng, Yu; Eirin, Alfonso; Zhu, Xiang-Yang; Tang, Hui; Lerman, Lilach O.] Mayo Clin, Div Nephrol & Hypertens, Dept Med, Rochester, MN USA.
   [Meng, Yu] Jinan Univ, Dept Nephrol, Hosp 1, Guangzhou, Guangdong, Peoples R China.
   [Chanana, Pritha] Mayo Clin, Hlth Sci Res & Biomed Stat & Informat, Rochester, MN USA.
   [Lerman, Amir; Lerman, Lilach O.] Mayo Clin, Cardiovasc Dis, Rochester, MN USA.
   [van Wijnen, Andre J.] Mayo Clin, Orthoped Surg, Rochester, MN USA.
C3 Mayo Clinic; Jinan University; Mayo Clinic; Mayo Clinic; Mayo Clinic
RP Lerman, LO (corresponding author), Mayo Clin, Div Nephrol & Hypertens, 200 First St SW, Rochester, MN 55905 USA.
EM lerman.lilach@mayo.edu
RI Lerman, Lilach/M-4962-2017; Eirin, Alfonso/N-9873-2013; van Wijnen,
   Andre/AAG-3578-2019
OI Eirin, Alfonso/0000-0002-3864-9644; van Wijnen, Andre
   J./0000-0002-4458-0946; Chanana, Pritha/0000-0003-2255-8905
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [DK102325, DK104273, DK106427, DK73608, HL123160]
FX National Institute of Diabetes and Digestive and Kidney Diseases, Grant
   numbers: DK102325, DK104273, DK106427, DK73608, HL123160
CR Abdoul-Azize S, 2016, EUR J PHARMACOL, V784, P90, DOI 10.1016/j.ejphar.2016.05.014
   Barrey E, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020220
   Bindea G, 2009, BIOINFORMATICS, V25, P1091, DOI 10.1093/bioinformatics/btp101
   Calvo SE, 2016, NUCLEIC ACIDS RES, V44, pD1251, DOI 10.1093/nar/gkv1003
   Casalena G, 2014, AM J PHYSIOL-RENAL, V306, pF1372, DOI 10.1152/ajprenal.00608.2013
   Chen L, 2014, J NANOMATER, V2014, P1, DOI DOI 10.1186/1687-1847-2014-251
   Coronnello C, 2012, PLOS COMPUT BIOL, V8, DOI 10.1371/journal.pcbi.1002830
   Crabbé MAE, 2016, STEM CELL TRANSL MED, V5, P709, DOI 10.5966/sctm.2015-0154
   Crespo-Diaz R, 2011, CELL TRANSPLANT, V20, P797, DOI 10.3727/096368910X543376
   Du JK, 2016, FREE RADICAL BIO MED, V96, P406, DOI 10.1016/j.freeradbiomed.2016.05.006
   Dudakovic A, 2014, J CELL BIOCHEM, V115, P1816, DOI 10.1002/jcb.24852
   Eirin A, 2017, TRANSL RES, V184, P45, DOI 10.1016/j.trsl.2017.03.002
   Eirin A, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0174303
   Eirin A, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.115.003118
   Eirin A, 2015, STEM CELL RES THER, V6, DOI 10.1186/scrt541
   Eirin A, 2014, GENE, V551, P55, DOI 10.1016/j.gene.2014.08.041
   Eirin A, 2014, CARDIOVASC RES, V103, P461, DOI 10.1093/cvr/cvu157
   Eirin A, 2012, HYPERTENSION, V60, P1242, DOI 10.1161/HYPERTENSIONAHA.112.199919
   Farrelly E, 2001, ANAL BIOCHEM, V293, P269, DOI 10.1006/abio.2001.5139
   Folmes CDL, 2012, CELL STEM CELL, V11, P596, DOI 10.1016/j.stem.2012.10.002
   Han TS, 2016, JRSM CARDIOVASC DIS, V5, DOI 10.1177/2048004016633371
   He L, 2004, NAT REV GENET, V5, P522, DOI 10.1038/nrg1379
   Jordan SD, 2011, NAT CELL BIOL, V13, P434, DOI 10.1038/ncb2211
   Kadye R, 2014, IUBMB LIFE, V66, P42, DOI 10.1002/iub.1234
   Kang T, 2013, J BIOL CHEM, V288, P34394, DOI 10.1074/jbc.M113.514372
   Kern S, 2006, STEM CELLS, V24, P1294, DOI 10.1634/stemcells.2005-0342
   Ludin A, 2014, ANTIOXID REDOX SIGN, V21, P1605, DOI 10.1089/ars.2014.5941
   Mori M, 2012, PLOS BIOL, V10, DOI 10.1371/journal.pbio.1001314
   Mukhopadhyay P, 2007, BIOCHEM BIOPH RES CO, V358, P203, DOI 10.1016/j.bbrc.2007.04.106
   Niimi K, 2012, FREE RADICAL BIO MED, V52, P1207, DOI 10.1016/j.freeradbiomed.2012.01.005
   Oskowitz AZ, 2008, P NATL ACAD SCI USA, V105, P18372, DOI 10.1073/pnas.0809807105
   Parker GC, 2009, STEM CELLS DEV, V18, P803, DOI 10.1089/scd.2009.1806.edi
   Pawar AS, 2015, OBESITY, V23, P399, DOI 10.1002/oby.20971
   Perales-Clemente E, 2014, ANTIOXID REDOX SIGN, V21, P1648, DOI 10.1089/ars.2014.6000
   Ramzan R, 2010, BBA-BIOENERGETICS, V1797, P1672, DOI 10.1016/j.bbabio.2010.06.005
   Robinson MD, 2010, BIOINFORMATICS, V26, P139, DOI 10.1093/bioinformatics/btp616
   Rohban R, 2017, STEM CELLS INT, V2017, DOI 10.1155/2017/5173732
   Saad A, 2016, STEM CELL RES THER, V7, DOI 10.1186/s13287-016-0389-x
   Sun ZF, 2014, BMC GENOMICS, V15, DOI 10.1186/1471-2164-15-423
   Ucar A, 2012, NAT COMMUN, V3, DOI 10.1038/ncomms2090
   Weber TA, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0063683
   Wei X, 2013, ACTA PHARMACOL SIN, V34, P747, DOI 10.1038/aps.2013.50
   Zhao LQ, 2015, ONCOTARGET, V6, P15995, DOI 10.18632/oncotarget.4138
   Zhu XY, 2016, STEM CELL TRANSL MED, V5, P893, DOI 10.5966/sctm.2015-0240
NR 44
TC 42
Z9 43
U1 0
U2 45
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD AUG
PY 2018
VL 233
IS 8
BP 5926
EP 5936
DI 10.1002/jcp.26402
PG 11
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA GD8XM
UT WOS:000430797600039
PM 29243809
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lohr, M
   Jensen, A
   Eriksen, L
   Gronbæk, M
   Loft, S
   Moller, P
AF Lohr, Mille
   Jensen, Annie
   Eriksen, Louise
   Gronbaek, Morten
   Loft, Steffen
   Moller, Peter
TI Age and metabolic risk factors associated with oxidatively damaged DNA
   in human peripheral blood mononuclear cells
SO ONCOTARGET
LA English
DT Article
DE 8-oxodG; comet assay; metabolic syndrome; obesity; oxidative stress
ID COMET ASSAY; FATTY-ACIDS; INSULIN-RESISTANCE; STRAND BREAKS; STRESS;
   REPAIR; 8-OXO-7,8-DIHYDRO-2'-DEOXYGUANOSINE; INFLAMMATION; POPULATION;
   CANCER
AB Aging is associated with oxidative stress-generated damage to DNA and this could be related to metabolic disturbances. This study investigated the association between levels of oxidatively damaged DNA in peripheral blood mononuclear cells (PBMCs) and metabolic risk factors in 1,019 subjects, aged 18-93 years. DNA damage was analyzed as strand breaks by the comet assay and levels of formamidopyrimidine (FPG-) and human 8-oxoguanine DNA glycosylase 1 (hOGG1)-sensitive sites There was an association between age and levels of FPG-sensitive sites for women, but not for men. The same tendency was observed for the level of hOGG1-sensitive sites, whereas there was no association with the level of strand breaks. The effect of age on oxidatively damaged DNA in women disappeared in multivariate models, which showed robust positive associations between DNA damage and plasma levels of triglycerides, cholesterol and glycosylated hemoglobin (HbA(1c)). In the group of men, there were significant positive associations between alcohol intake, HbA(1c) and FPG-sensitive sites in multivariate analysis. The levels of metabolic risk factors were positively associated with age, yet only few subjects fulfilled all metabolic syndrome criteria. In summary, positive associations between age and levels of oxidatively damaged DNA appeared mediated by age-related increases in metabolic risk factors.
C1 [Lohr, Mille; Jensen, Annie; Loft, Steffen; Moller, Peter] Univ Copenhagen, Dept Publ Hlth, Environm Hlth Sect, Copenhagen, Denmark.
   [Eriksen, Louise; Gronbaek, Morten] Univ Southern Denmark, Natl Inst Publ Hlth, Odense, Denmark.
C3 University of Copenhagen; University of Southern Denmark
RP Moller, P (corresponding author), Univ Copenhagen, Dept Publ Hlth, Environm Hlth Sect, Copenhagen, Denmark.
EM pemo@sund.ku.dk
OI Loft, Steffen/0000-0001-9552-8518; Gronbaek, Morten
   Klocker/0000-0002-8473-6474
CR Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Beltrán-Sánchez H, 2013, J AM COLL CARDIOL, V62, P697, DOI 10.1016/j.jacc.2013.05.064
   Bianchini F, 2001, CARCINOGENESIS, V22, P885, DOI 10.1093/carcin/22.6.885
   Borena W, 2011, CANCER CAUSE CONTROL, V22, P291, DOI 10.1007/s10552-010-9697-0
   Collins A, 2014, MUTAT RES-REV MUTAT, V759, P27, DOI 10.1016/j.mrrev.2013.10.001
   Collins AR, 1998, FREE RADICAL BIO MED, V25, P373, DOI 10.1016/S0891-5849(98)00053-7
   Dusinská M, 2006, MUTAGENESIS, V21, P205, DOI 10.1093/mutage/gel016
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Eriksen L, 2011, SCAND J PUBLIC HEALT, V39, P203, DOI 10.1177/1403494810393557
   Espinosa O, 2007, FREE RADICAL RES, V41, P546, DOI 10.1080/10715760601164050
   Floyd RA, 2011, FREE RADICAL BIO MED, V51, P931, DOI 10.1016/j.freeradbiomed.2011.04.014
   Forchhammer L, 2010, MUTAGENESIS, V25, P113, DOI 10.1093/mutage/gep048
   Gackowski D, 2001, FREE RADICAL BIO MED, V31, P542, DOI 10.1016/S0891-5849(01)00614-1
   Ghanim H, 2004, CIRCULATION, V110, P1564, DOI 10.1161/01.CIR.0000142055.53122.FA
   Giovannelli L, 2002, CARCINOGENESIS, V23, P1483, DOI 10.1093/carcin/23.9.1483
   Hofer T, 2006, FREE RADICAL RES, V40, P707, DOI 10.1080/10715760500525807
   Hoffmann H, 2005, MUTAGENESIS, V20, P455, DOI 10.1093/mutage/gei064
   Humphreys V, 2007, AGE AGEING, V36, P521, DOI 10.1093/ageing/afm107
   Iyer A, 2010, NAT REV ENDOCRINOL, V6, P71, DOI 10.1038/nrendo.2009.264
   Jacob KD, 2013, MECH AGEING DEV, V134, P139, DOI 10.1016/j.mad.2013.02.008
   Jensen A, 2012, FREE RADICAL BIO MED, V52, P118, DOI 10.1016/j.freeradbiomed.2011.09.038
   Johnson JA, 2012, DIABETOLOGIA, V55, P1607, DOI 10.1007/s00125-012-2525-1
   Karpe F, 2011, DIABETES, V60, P2441, DOI 10.2337/db11-0425
   Loft S, 2008, EUR J NUTR, V47, P19, DOI 10.1007/s00394-008-2004-0
   Martinez-Hervas S, 2008, ATHEROSCLEROSIS, V199, P384, DOI 10.1016/j.atherosclerosis.2007.11.023
   Maynard S, 2015, ACTA PHYSIOL, V213, P156, DOI 10.1111/apha.12296
   Merzenich H, 2001, CANCER EPIDEM BIOMAR, V10, P515
   Mikkelsen L, 2009, FREE RADICAL BIO MED, V47, P608, DOI 10.1016/j.freeradbiomed.2009.05.030
   Milic M, 2013, MUTAT RES-GEN TOX EN, V758, P1, DOI 10.1016/j.mrgentox.2013.07.013
   Moller P, 2003, CANCER EPIDEM BIOMAR, V12, P1016
   Moller P, 2000, CANCER EPIDEM BIOMAR, V9, P1005
   Moller P, 2006, FREE RADICAL BIO MED, V41, P388, DOI 10.1016/j.freeradbiomed.2006.04.001
   Moller P, 2015, ENVIRON MOL MUTAGEN, V56, P97, DOI 10.1002/em.21899
   Moller P, 2010, FREE RADICAL BIO MED, V48, P1275, DOI 10.1016/j.freeradbiomed.2010.02.003
   Mota MP, 2010, AGE, V32, P337, DOI 10.1007/s11357-010-9138-8
   Müezzinler A, 2013, AGEING RES REV, V12, P509, DOI 10.1016/j.arr.2013.01.003
   Neuschwander-Tetri BA, 2010, HEPATOLOGY, V52, P774, DOI 10.1002/hep.23719
   Ponnappan S, 2011, ANTIOXID REDOX SIGN, V14, P1551, DOI 10.1089/ars.2010.3228
   Renehan AG, 2008, LANCET, V371, P569, DOI 10.1016/S0140-6736(08)60269-X
   Rolo AP, 2012, FREE RADICAL BIO MED, V52, P59, DOI 10.1016/j.freeradbiomed.2011.10.003
   Rytter E, 2009, BRIT J NUTR, V101, P1423, DOI 10.1017/S0007114508076204
   Scuteri A, 2015, EUR J PREV CARDIOL, V22, P486, DOI 10.1177/2047487314525529
   Siomek A, 2007, ANTIOXID REDOX SIGN, V9, P143, DOI 10.1089/ars.2007.9.143
   Slyskova J, 2014, DNA REPAIR, V16, P66, DOI 10.1016/j.dnarep.2014.01.016
   Smith CA, 2006, COGNITION EMOTION, V20, P1, DOI 10.1080/02699930500465950
   Soares JP, 2013, CELL BIOCHEM FUNCT, V31, P743, DOI 10.1002/cbf.2966
   Sohal RS, 2012, FREE RADICAL BIO MED, V52, P539, DOI 10.1016/j.freeradbiomed.2011.10.445
   Sonta T, 2004, FREE RADICAL BIO MED, V37, P115, DOI 10.1016/j.freeradbiomed.2004.04.001
   Stocks T, 2009, PLOS MED, V6, DOI 10.1371/journal.pmed.1000201
   Strohmaier S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054242
   Thorlaksdottir AY, 2007, NUTR CANCER, V59, P21, DOI 10.1080/01635580701365092
   Tilg H, 2010, HEPATOLOGY, V52, P1836, DOI 10.1002/hep.24001
   Tripathy D, 2003, DIABETES, V52, P2882, DOI 10.2337/diabetes.52.12.2882
   Trzeciak AR, 2012, MUTAT RES-FUND MOL M, V736, P93, DOI 10.1016/j.mrfmmm.2012.01.002
   van den Berg R, 2001, J NUTR, V131, P1714, DOI 10.1093/jn/131.6.1714
   van Vliet-Ostaptchouk JV, 2014, BMC ENDOCR DISORD, V14, DOI 10.1186/1472-6823-14-9
NR 56
TC 36
Z9 37
U1 0
U2 7
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
EI 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD FEB 20
PY 2015
VL 6
IS 5
BP 2641
EP 2653
DI 10.18632/oncotarget.3202
PG 13
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA CF6VK
UT WOS:000352694400008
PM 25650665
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU de Souza, GA
   de Marqui, SV
   Matias, JN
   Guiguer, EL
   Barbalho, SM
AF de Souza, Gabriela Achete
   de Marqui, Samylla Vaz
   Matias, Julia Novaes
   Guiguer, Elen Landgraf
   Barbalho, Sandra Maria
TI Effects of Ginkgo biloba on Diseases Related to Oxidative Stress
SO PLANTA MEDICA
LA English
DT Review
DE Ginkgo biloba; Ginkgoceae; antioxidant; oxidative stress;
   anti-inflammatory
ID EXTRACT-EGB 761; LEAF EXTRACT; NEUROPROTECTIVE ROLE; COGNITIVE FUNCTION;
   METABOLIC SYNDROME; L. EXTRACT; INJURY; INHIBITION; EFFICACY; DAMAGE
AB Ginkgo biloba (GB) is one of the most widely used phytotherapeutic products in the world, and its extract has beneficial properties for the treatment of several pathologies, such as diabetic cardiomyopathy, neurodegenerative diseases, cataracts, hearing loss, myocardial lesion, hippocampus neuronal lesions, morphometry testicular changes, and liver damage. This review aims to investigate the effects of GB on diseases related to oxidative stress. Databases such as MEDLINE/PUBMED and EMBASE were consulted, and PRISMA guidelines were used to build the review. This plant has antioxidant properties since it regulates the expression of antioxidant enzymes positively and reduces reactive oxygen and nitrogen species, contributing to the reduction of lipid peroxidation. It also exhibits anti-inflammatory properties, inhibiting the expression of pro-inflammatory cytokines, such as IL-1, IL-6, and TNF- alpha . In animal models, the use of GB can show positive effects on brain damage, neurodegenerative diseases, myocardial injury, and renal and liver damage. In humans, the positive effects were shown in diabetes, metabolic syndrome, and ischemic colitis. These effects are due to the presence of compounds such as bilobalide, isoramnetina, quercetin, kaempferol, and ginkgolides A, B, and C. For these reasons, GB can be a low-cost alternative to the therapeutic approach of several pathologies since it acts in the prevention, treatment, and inhibition of several complications of common comorbidities.
C1 [de Souza, Gabriela Achete; de Marqui, Samylla Vaz; Matias, Julia Novaes; Guiguer, Elen Landgraf; Barbalho, Sandra Maria] Univ Marilia UNIMAR, Sch Med, Dept Biochem & Pharmacol, Marilia, SP, Brazil.
   [Guiguer, Elen Landgraf; Barbalho, Sandra Maria] Fac Food Technol Marilia, FATEC, Dept Biochem & Nutr, Marilia, SP, Brazil.
C3 Universidade de Marilia
RP Barbalho, SM (corresponding author), Univ Marilia, Sch Med, Dept Biochem & Pharmacol, Ave Higino Muzzi Filho 1001, BR-17525902 Marilia, SP, Brazil.
EM smbarbalho@gmail.com
RI barbalho, sandra/Z-3515-2019; Guiguer, Elen/AAN-1883-2020
OI Novaes Matias, Julia/0000-0003-0265-3016; Guiguer,
   Elen/0000-0002-9930-9694; Achete de Souza, Gabriela/0000-0002-5612-3486
CR Abdel-Zaher AO, 2018, CLIN EXP HYPERTENS, V40, P703, DOI 10.1080/10641963.2018.1425421
   Ahmed AI, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/6959274
   Ahmed HH, 2017, BIOMED PHARMACOTHER, V95, P387, DOI 10.1016/j.biopha.2017.08.103
   Aydin D, 2016, CLIN INVEST MED, V39, pS100
   Aziz TA, 2018, THER CLIN RISK MANAG, V14, P1219, DOI 10.2147/TCRM.S169503
   Badem S, 2014, ANN VASC SURG, V28, P1296, DOI 10.1016/j.avsg.2014.02.020
   Belviranli M, 2015, BEHAV BRAIN RES, V278, P453, DOI 10.1016/j.bbr.2014.10.032
   Bjorklund G, 2018, BASIC CLIN PHARMACOL, V122, P539, DOI 10.1111/bcpt.12972
   Burgos-Morón E, 2019, J CLIN MED, V8, DOI 10.3390/jcm8091385
   Cao SQ, 2015, CURR EYE RES, V40, P1028, DOI 10.3109/02713683.2014.980005
   Chen M, 2018, EUR J PHARMACOL, V833, P221, DOI 10.1016/j.ejphar.2018.06.012
   Chen XJ, 2019, DRUG DES DEV THER, V13, P647, DOI 10.2147/DDDT.S191537
   Choudhary Sunayna, 2013, Pharmacogn Rev, V7, P81, DOI 10.4103/0973-7847.120505
   El Tabaa MM, 2017, NEUROCHEM INT, V108, P199, DOI 10.1016/j.neuint.2017.03.019
   El-Ghazaly MA, 2015, TOXICOL IND HEALTH, V31, P1128, DOI 10.1177/0748233713487251
   Fang HM, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000012166
   Gevrek F, 2017, BRATISL MED J, V118, P676, DOI 10.4149/BLL_2017_128
   Günay NE, 2018, BALK MED J, V35, P174, DOI 10.4274/balkanmedj.2016.1830
   Harada S, 2015, J NUTR SCI VITAMINOL, V61, P167, DOI 10.3177/jnsv.61.167
   Hirata BKS, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00284
   Hu HJ, 2018, ADV CLIN EXP MED, V27, P913, DOI 10.17219/acem/70414
   Huang XF, 2019, ACTA PHARMACOL SIN, V40, P192, DOI 10.1038/s41401-018-0017-7
   Jeong HS, 2017, BIOMED PHARMACOTHER, V88, P625, DOI 10.1016/j.biopha.2017.01.114
   Jiang L, 2017, J PHARMACEUT BIOMED, V136, P44, DOI 10.1016/j.jpba.2016.12.033
   Kaur N, 2015, J NEUROSCI RES, V93, P938, DOI 10.1002/jnr.23565
   Kaur S, 2018, INFLAMMOPHARMACOLOGY, V26, P87, DOI 10.1007/s10787-017-0396-2
   Khedr MH, 2018, INT J RADIAT BIOL, V94, P37, DOI 10.1080/09553002.2018.1407463
   Lebda MA, 2018, LIFE SCI, V212, P251, DOI 10.1016/j.lfs.2018.10.011
   Lee CY, 2014, J AGR FOOD CHEM, V62, P6337, DOI 10.1021/jf501913b
   Li HX, 2018, NUTRIENTS, V10, DOI 10.3390/nu10050589
   Li HZ, 2015, FOOD FUNCT, V6, P470, DOI 10.1039/c4fo00739e
   Li YP, 2017, MOL MED REP, V16, P3657, DOI 10.3892/mmr.2017.6999
   Liang ZH, 2016, BEHAV BRAIN RES, V314, P116, DOI 10.1016/j.bbr.2016.08.001
   Lin HX, 2014, TOXICOL SCI, V139, P338, DOI 10.1093/toxsci/kfu037
   Liu Q, 2019, CELL STRESS CHAPERON, V24, P441, DOI 10.1007/s12192-019-00977-1
   Liu X, 2015, BRAIN BEHAV IMMUN, V46, P121, DOI 10.1016/j.bbi.2015.01.011
   Lu L, 2016, CLIN EXP DERMATOL, V41, P64, DOI 10.1111/ced.12664
   Lu Q, 2018, ACTA BIOCHIM POL, V65, P35, DOI 10.18388/abp.2016_1387
   Martínez-Solís I, 2019, PLANTA MED, V85, P1292, DOI 10.1055/a-0947-5712
   Mi XS, 2013, J INTEGR MED-JIM, V11, P233, DOI 10.3736/jintegrmed2013037
   Mohamed NE, 2017, NUTRITION, V35, P93, DOI 10.1016/j.nut.2016.10.012
   Parimoo HA, 2014, TOXICON, V81, P1, DOI 10.1016/j.toxicon.2014.01.013
   Park SY, 2014, NOISE HEALTH, V16, P257, DOI 10.4103/1463-1741.140497
   Qin YR, 2018, J ALZHEIMERS DIS, V65, P243, DOI [10.3233/JAD-180426, 10.3233/jad-180426]
   Rhee KJ, 2015, INT J MED SCI, V12, P987, DOI 10.7150/ijms.13339
   Ribeiro ML, 2016, BEHAV BRAIN RES, V313, P144, DOI 10.1016/j.bbr.2016.06.029
   Saini AS, 2014, PHARMACOGN MAG, V10, P172, DOI 10.4103/0973-1296.131031
   Senoner T, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092090
   Serrano-García N, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/495703
   Sharma M, 2016, J AM GERIATR SOC, V64, P1171, DOI 10.1111/jgs.14140
   Siegel G, 2014, ATHEROSCLEROSIS, V237, P584, DOI 10.1016/j.atherosclerosis.2014.10.023
   Sjostrand AP, 2016, AM J OTOLARYNG, V37, P416, DOI 10.1016/j.amjoto.2016.05.004
   Hirata BKS, 2015, MEDIAT INFLAMM, V2015, DOI 10.1155/2015/419106
   Tang YP, 2017, ONCOTARGET, V8, P86671, DOI 10.18632/oncotarget.21372
   Tao Z, 2019, FOOD FUNCT, V10, P2209, DOI 10.1039/c8fo02506a
   Tian JF, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/2370617
   Trebatická J, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/248529
   Vaghef L, 2017, INT J ANGIOL, V26, P158, DOI 10.1055/s-0036-1588024
   Wan WB, 2016, EXP GERONTOL, V81, P92, DOI 10.1016/j.exger.2016.05.007
   Wang A, 2018, MED SCI MONITOR, V24, P3159, DOI 10.12659/MSM.910718
   Wang CP, 2016, PHYTOTHER RES, V30, P774, DOI 10.1002/ptr.5572
   Wang H, 2017, BMC COMPLEM ALTERN M, V17, DOI [10.1186/s12906-017-2014-7, 10.1186/s12879-017-2849-z]
   Wang JF, 2015, TOXICOL IN VITRO, V29, P380, DOI 10.1016/j.tiv.2014.10.015
   Wang L, 2019, IRAN J BASIC MED SCI, V22, P140, DOI 10.22038/ijbms.2018.26228.6569
   Wang L, 2013, J ETHNOPHARMACOL, V150, P308, DOI 10.1016/j.jep.2013.08.048
   Wang YQ, 2015, FREE RADICAL RES, V49, P1069, DOI 10.3109/10715762.2015.1032958
   Wang YY, 2015, DRUG DES DEV THER, V9, P6303, DOI 10.2147/DDDT.S93732
   Wang Z, 2016, PHYTOMEDICINE, V23, P621, DOI 10.1016/j.phymed.2016.03.005
   Wu FG, 2016, BIOMED PHARMACOTHER, V81, P71, DOI 10.1016/j.biopha.2016.03.048
   Wu JQ, 2013, PROG NEURO-PSYCHOPH, V46, P200, DOI 10.1016/j.pnpbp.2013.02.015
   Yallapragada PR, 2015, J ENVIRON PATHOL TOX, V34, P161, DOI 10.1615/JEnvironPatholToxicolOncol.2015013095
   Ye NH, 2016, BIOMOL THER, V24, P40, DOI 10.4062/biomolther.2015.077
   Zayed AE, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/1785614
   Zeng Y-Q, 2016, J Prev Alzheimers Dis, V3, P24, DOI 10.14283/jpad.2015.84
   Zhang J, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8636835
   Zhang J, 2017, DYN GAMES APPL, V7, P112, DOI 10.1007/s13235-015-0165-z
   Zhang L, 2019, J CELL BIOCHEM, V120, P8078, DOI 10.1002/jcb.28086
   Zhao Y, 2018, COMPLEMENT THER MED, V40, P120, DOI 10.1016/j.ctim.2018.08.007
NR 78
TC 74
Z9 80
U1 0
U2 42
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0032-0943
EI 1439-0221
J9 PLANTA MED
JI Planta Med.
PD APR
PY 2020
VL 86
IS 6
BP 376
EP 386
DI 10.1055/a-1109-3405
PG 11
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA LE7HE
UT WOS:000526892900001
PM 32097975
OA Bronze
DA 2025-06-11
ER

PT J
AU Yamato, M
   Shiba, T
   Yoshida, M
   Ide, T
   Seri, N
   Kudou, W
   Kinugawa, S
   Tsutsui, H
AF Yamato, Mayumi
   Shiba, Takeshi
   Yoshida, Masayoshi
   Ide, Tomomi
   Seri, Naoko
   Kudou, Wataru
   Kinugawa, Shintaro
   Tsutsui, Hiroyuki
TI Fatty acids increase the circulating levels of oxidative stress factors
   in mice with diet-induced obesity via redox changes of albumin
SO FEBS JOURNAL
LA English
DT Article
DE ESR; albumin; fatty acid; obesity; oxidative stress
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; INDUCED INSULIN-RESISTANCE;
   SKELETAL-MUSCLE CELLS; HUMAN-SERUM-ALBUMIN; METABOLIC SYNDROME;
   LIPID-PEROXIDATION; BINDING-SITES; ANTIOXIDANT; PLASMA; MECHANISM
AB Plasma concentrations of free fatty acids are increased in metabolic syndrome, and the increased fatty acids may cause cellular damage via the induction of oxidative stress. The present study was designed to determine whether the increase in fatty acids can modify the free sulfhydryl group in position 34 of albumin (Cys34) and enhance the redox-cycling activity of the copper-albumin complex in high-fat diet-induced obese mice. The mice were fed with commercial normal diet or high-fat diet. and water ad libitum for 3 months. The high-fat diet-fed mice developed obesity, hyperlipemia, and hyperglycemia. The plasma fatty acid/albumin ratio also significantly increased in high-fat diet-fed mice. The increased fatty acid/albumin ratio was associated with conformational changes in albumin and the oxidation of sulfhydryl groups. Moreover, an ascorbic acid radical, an index of redox-cycling activity of the copper-albumin complex, was detected only in the plasma from obese mice, whereas the plasma concentrations of ascorbic acid were not altered. Plasma thiobarbituric acid reactive substances were significantly increased in the high-fat diet group. These results indicate that the increased plasma fatty acids in the high-fat diet group resulted in the activated redox cycling of the copper albumin complex and excessive lipid peroxidation.
C1 Hokkaido Univ, Grad Sch Med, Dept Cardiovasc Med, Kita Ku, Sapporo, Hokkaido 060, Japan.
   Kyushu Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Fukuoka 812, Japan.
   Kyushu Univ, Fac Pharmaceut Sci, Dept REDOX Med Sci, Fukuoka 812, Japan.
C3 Hokkaido University; Kyushu University; Kyushu University
RP Tsutsui, H (corresponding author), Hokkaido Univ, Grad Sch Med, Dept Cardiovasc Med, Kita Ku, Kita-15,Nishi-7, Sapporo, Hokkaido 060, Japan.
EM htsutsui@med.hokudai.ac.jp
RI Kinugawa, Shintaro/E-1268-2012; Tsutsui, Hiroyuki/A-4070-2012
OI Yoshida, Masayoshi/0000-0002-5207-5544
CR Andorn AC, 1996, J NEUROCHEM, V67, P717
   BIRKETT DJ, 1977, MOL PHARMACOL, V13, P987
   CARLBERG I, 1975, J BIOL CHEM, V250, P5475
   CARTER DC, 1994, ADV PROTEIN CHEM, V45, P153
   Curry S, 1998, NAT STRUCT BIOL, V5, P827, DOI 10.1038/1869
   DASGUPTA A, 1992, LIFE SCI, V50, P875, DOI 10.1016/0024-3205(92)90206-5
   Du XL, 2006, J CLIN INVEST, V116, P1071, DOI 10.1172/JCI23354
   ELLMAN G, 1979, ANAL BIOCHEM, V93, P98, DOI 10.1016/S0003-2697(79)80122-0
   Fortuño A, 2006, DIABETES, V55, P209, DOI 10.2337/diabetes.55.1.209
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   GARDNER HW, 1989, FREE RADICAL BIO MED, V7, P65, DOI 10.1016/0891-5849(89)90102-0
   Gryzunov YA, 2003, ARCH BIOCHEM BIOPHYS, V413, P53, DOI 10.1016/S0003-9861(03)00091-2
   HALLIWELL B, 1990, ARCH BIOCHEM BIOPHYS, V280, P1, DOI 10.1016/0003-9861(90)90510-6
   HALLIWELL B, 1990, METHOD ENZYMOL, V186, P1
   HALLIWELL B, 1988, BIOCHEM PHARMACOL, V37, P569, DOI 10.1016/0006-2952(88)90126-8
   Hasty AH, 2007, J NUTR BIOCHEM, V18, P127, DOI 10.1016/j.jnutbio.2006.03.012
   Hayashi T, 2002, J CHROMATOGR B, V772, P139, DOI 10.1016/S1570-0232(02)00068-5
   HOSTMARK AT, 1995, MED HYPOTHESES, V44, P539, DOI 10.1016/0306-9877(95)90520-0
   Ishola DA, 2006, KIDNEY INT, V70, P724, DOI 10.1038/sj.ki.5001629
   Jensen T, 2002, DIABETES CARE, V25, P1914, DOI 10.2337/diacare.25.11.1914
   Jeon JY, 2006, DIABETES, V55, P428, DOI 10.2337/diabetes.55.02.06.db05-0203
   Jové M, 2006, ENDOCRINOLOGY, V147, P552, DOI 10.1210/en.2005-0440
   NOEL JKF, 1972, J BIOL CHEM, V247, P7391
   Rachek LI, 2007, ENDOCRINOLOGY, V148, P293, DOI 10.1210/en.2006-0998
   Roberts CK, 2006, METABOLISM, V55, P928, DOI 10.1016/j.metabol.2006.02.022
   Roden M, 1996, J CLIN INVEST, V97, P2859, DOI 10.1172/JCI118742
   Sarafidis PA, 2007, J HUM HYPERTENS, V21, P12, DOI 10.1038/sj.jhh.1002103
   Shi H, 2006, J CLIN INVEST, V116, P3015, DOI 10.1172/JCI28898
   SHIMIZU S, 1979, BIOCHEM BIOPH RES CO, V91, P108, DOI 10.1016/0006-291X(79)90589-8
   TAKABAYASHI K, 1983, EUR J BIOCHEM, V136, P291, DOI 10.1111/j.1432-1033.1983.tb07740.x
   Tripathy D, 2003, DIABETES, V52, P2882, DOI 10.2337/diabetes.52.12.2882
   Vartanian V, 2006, P NATL ACAD SCI USA, V103, P1864, DOI 10.1073/pnas.0507444103
   WOOD R, 1983, J CHROMATOGR, V254, P237, DOI 10.1016/S0021-9673(01)88338-2
   Yamaguchi Y, 2006, NITRIC OXIDE-BIOL CH, V15, P380, DOI 10.1016/j.niox.2006.04.264
   YAMAMOTO Y, 1993, ARCH BIOCHEM BIOPHYS, V305, P541, DOI 10.1006/abbi.1993.1458
   Zaitseva I, 1999, J CHROMATOGR B, V727, P15, DOI 10.1016/S0378-4347(99)00051-1
   Zhang WY, 2006, ARTERIOSCL THROM VAS, V26, P514, DOI 10.1161/01.ATV.0000200226.53994.09
NR 38
TC 39
Z9 43
U1 0
U2 6
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 1742-464X
J9 FEBS J
JI FEBS J.
PD AUG
PY 2007
VL 274
IS 15
BP 3855
EP 3863
DI 10.1111/j.1742-4658.2007.05914.x
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 199UG
UT WOS:000248720100008
PM 17617229
DA 2025-06-11
ER

PT J
AU Chen, K
   Wang, G
   Jin, HZ
   Xu, JH
   Zhu, XJ
   Zheng, M
   Gu, H
AF Chen, Kun
   Wang, Gang
   Jin, Hongzhong
   Xu, Jinhua
   Zhu, Xuejun
   Zheng, Min
   Gu, Heng
TI Clinic characteristics of psoriasis in China: a nationwide survey in
   over 12000 patients
SO ONCOTARGET
LA English
DT Article
DE psoriasis; epidemiology; phenotype; Chinese Han
ID METABOLIC SYNDROME; PREVALENCE; RISK; HYPERTENSION; ARTHRITIS; SMOKING;
   DISEASE
AB Psoriasis is a worldwide chronic inflammatory disease, involving both skin and joints. In order to characterize psoriasis in Han Chinese population, we conducted this nationwide prospective and hospital based survey, in which 56 hospitals with departments of dermatology participated, located in 33 cities across China. A total of 12,031 outpatients with psoriasis were registered during 2009 to 2010, which the data was collected by standard questionnaires. The main data acquisition included demographics, family history, disease status and other comorbidities. Physical and dermatological examination, including body surface area (BSA) and psoriasis area severity index ( PASI) were applied to evaluate the disease severity. Descriptive statistics, 2 tailed t-test and chi-square test were used appropriately for the statistical analysis. From the study, we found that the male and female ratio of the patients was 1.49: 1. Mean age of onset was 30.2 +/- 14.5 years for males and 27.1 +/- 15.6 years for females (P < 0.05). Scalp was the most common onset site (52.8%), The mean PASI was 18.70 +/- 10.01, indicating that most patients presenting at the hospitals had moderate-to-severe psoriasis and the majority was psoriasis vulgaris (96.5%). Among 12,031 patients, 23.1% had a family history of psoriasis, 16.1% had comorbidities, and 29.9% had nail changes. The most important aggravation factor was season change (60.2%), followed by psychological stress (34.5%), and there significant differences between genders on trigger factors. In conclusion, this study characterizing psoriasis in Han Chinese population, could be used as basic data for future study.
C1 [Chen, Kun; Gu, Heng] Chinese Acad Med Sci, Inst Dermatol, Nanjing, Jiangsu, Peoples R China.
   [Chen, Kun; Gu, Heng] Peking Union Med Coll, Nanjing, Jiangsu, Peoples R China.
   [Wang, Gang] Fourth Mil Med Univ, Xijing Hosp, Dept Dermatol, Xian, Shanxi, Peoples R China.
   [Jin, Hongzhong] Chinese Acad Med Sci, Peking Union Med Hosp, Beijing, Peoples R China.
   [Jin, Hongzhong] Peking Union Med Coll, Beijing, Peoples R China.
   [Xu, Jinhua] Fudan Univ, Huashan Hosp, Dept Dermatol, Shanghai, Peoples R China.
   [Zhu, Xuejun] Peking Univ, Hosp 1, Dept Dermatol, Beijing, Peoples R China.
   [Zheng, Min] Zhejiang Univ, Sch Med, Dept Dermatol, Affiliated Hosp 2, Hangzhou, Zhejiang, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Institute of Dermatology - CAMS; Chinese Academy of Medical Sciences -
   Peking Union Medical College; Peking Union Medical College; Air Force
   Medical University; Chinese Academy of Medical Sciences - Peking Union
   Medical College; Peking Union Medical College Hospital; Chinese Academy
   of Medical Sciences - Peking Union Medical College; Peking Union Medical
   College; Fudan University; Peking University; Zhejiang University
RP Gu, H (corresponding author), Chinese Acad Med Sci, Inst Dermatol, Nanjing, Jiangsu, Peoples R China.; Gu, H (corresponding author), Peking Union Med Coll, Nanjing, Jiangsu, Peoples R China.; Zheng, M (corresponding author), Zhejiang Univ, Sch Med, Dept Dermatol, Affiliated Hosp 2, Hangzhou, Zhejiang, Peoples R China.
EM minz@zju.edu.cn; guhengy@yahoo.com.cn
RI Zheng, Mingyue/HHZ-4062-2022; Wang, Gang/H-6710-2019
OI Zhang, Jiahe/0000-0003-4147-394X; Wang, Gang/0000-0002-5842-8080
FU Leo Pharmaceutical Co., Shanghai, China; CAMS Innovation Fund for
   Medical Sciences [2016-12M-1-005]
FX This epidemiologic investigation into psoriasis was funded by Leo
   Pharmaceutical Co., Shanghai, China. And this work was supported by CAMS
   Innovation Fund for Medical Sciences (2016-12M-1-005). We extend our
   sincere thanks to Dr. Peter Pothula,BioQuest for his valuable editorial
   guidance and Dr. Stephan Weidinger, Kiel, for critical reading of the
   manuscript.
CR ANDRESSEN C, 1982, HAUTARZT, V33, P214
   Armstrong AW, 2013, J AM ACAD DERMATOL, V68, P654, DOI 10.1016/j.jaad.2012.08.015
   BRANDRUP F, 1982, ACTA DERM-VENEREOL, V62, P229
   Cohen AD, 2005, J DERMATOL TREAT, V16, P308, DOI 10.1080/09546630500375841
   Cohen BE, 2016, JAMA DERMATOL, V152, P73, DOI 10.1001/jamadermatol.2015.3605
   Davidovici BB, 2010, J INVEST DERMATOL, V130, P1785, DOI 10.1038/jid.2010.103
   Ding XL, 2012, EUR J DERMATOL, V22, P663, DOI 10.1684/ejd.2012.1802
   Elder JT, 2010, J INVEST DERMATOL, V130, P1213, DOI 10.1038/jid.2009.319
   Gisondi P, 2007, BRIT J DERMATOL, V157, P68, DOI 10.1111/j.1365-2133.2007.07986.x
   Gupta R, 2014, CURR DERMATOL REP, V3, P61, DOI 10.1007/s13671-013-0066-6
   HENSELER T, 1995, J AM ACAD DERMATOL, V32, P982, DOI 10.1016/0190-9622(95)91336-X
   Herron MD, 2005, ARCH DERMATOL, V141, P1527, DOI 10.1001/archderm.141.12.1527
   Lonnberg AS, 2016, ACTA DERM-VENEREOL, V96, P35, DOI 10.2340/00015555-2171
   Marino M G, 2004, Ann Ig, V16, P753
   Merola JF, 2016, CLIN EXP DERMATOL, V41, P486, DOI 10.1111/ced.12805
   MOLL J M H, 1973, Seminars in Arthritis and Rheumatism, V3, P55, DOI 10.1016/0049-0172(73)90035-8
   Naldi L, 2005, J INVEST DERMATOL, V125, P61, DOI 10.1111/j.0022-202X.2005.23681.x
   Ohara Y, 2015, J RHEUMATOL, V42, P1439, DOI 10.3899/jrheum.141598
   Parisi R, 2013, J INVEST DERMATOL, V133, P377, DOI 10.1038/jid.2012.339
   Phan C, 2016, ANN DERMATOL VENER, V143, P264, DOI 10.1016/j.annder.2015.06.024
   Prignano F, 2009, CLIN COSMET INVESTI, V2, P9
   Qureshi AA, 2009, ARCH DERMATOL, V145, P379, DOI 10.1001/archdermatol.2009.48
   Shao C., 1984, ZHONGHUA LIU XING BI, V19, P253
   Shin D, 2016, RHEUMATOL INT, V36, P207, DOI 10.1007/s00296-015-3365-3
   Shu Y, 1997, ZHONGHUA PIFUKE ZAZH, V30, P114
   Wang H, 2001, Zhonghua Liu Xing Bing Xue Za Zhi, V22, P215
   Zhang XJ, 2002, INT J DERMATOL, V41, P659, DOI 10.1046/j.1365-4362.2002.01595.x
NR 27
TC 48
Z9 58
U1 0
U2 10
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
EI 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD JUL 11
PY 2017
VL 8
IS 28
BP 46381
EP 46389
DI 10.18632/oncotarget.18453
PG 9
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA FA5SS
UT WOS:000405504600116
PM 28637026
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Matrisciano, F
AF Matrisciano, Francesco
TI Functional Nutrition as Integrated Intervention for In- and Outpatient
   with Schizophrenia
SO CURRENT NEUROPHARMACOLOGY
LA English
DT Review
DE Schizophrenia; neuroinflammation; synaptic plasticity; nutrition;
   functional foods; bioactive compounds
ID EPIGENETIC MODIFICATIONS; OXIDATIVE STRESS; ANTIINFLAMMATORY AGENTS;
   GABAERGIC INTERNEURONS; INHIBITORY NEURONS; METABOLIC SYNDROME; BIPOLAR
   DISORDER; PRENATAL STRESS; RISK-FACTORS; INFLAMMATION
AB Schizophrenia is a chronic and progressive disorder characterized by cognitive, emotional, and behavioral abnormalities associated with neuronal development and synaptic plasticity alterations. Genetic and epigenetic abnormalities in cortical parvalbumin-positive GABAergic interneurons and consequent alterations in glutamate-mediated excitatory neurotransmission during early neurodevelopment underlie schizophrenia manifestation and progression. Also, epigenetic alterations during pregnancy or early phases of postnatal life are associated with schizophrenia vulnerability and inflammatory processes, which are at the basis of brain pathology and a higher risk of comorbidities, including cardiovascular diseases and metabolic syndrome. In addition, schizophrenia patients adopt an unhealthy lifestyle and poor nutrition, leading to premature death. Here, I explored the role of functional nutrition as an integrated intervention for the long-term management of patients with schizophrenia. Several natural bioactive compounds in plant-based whole foods, including flavonoids, phytonutrients, vitamins, fatty acids, and minerals, modulate brain functioning by targeting neuroinflammation and improving cognitive decline. Although further clinical studies are needed, a functional diet rich in natural bioactive compounds might be effective in synergism with standard treatments to improve schizophrenia symptoms and reduce the risk of comorbidities.
C1 [Matrisciano, Francesco] Univ Illinois Chicago UIC, Psychiat Inst, Coll Med, Dept Psychiat, Chicago, IL 60607 USA.
C3 University of Illinois System; University of Illinois Chicago
RP Matrisciano, F (corresponding author), Univ Illinois Chicago UIC, Psychiat Inst, Coll Med, Dept Psychiat, Chicago, IL 60607 USA.
EM matrisci@uic.edu
FU "Sorgente srl" - Mental Health Community, Italy.; "Sorgente srl" -
   Mental Health Community, Italy
FX "Sorgente srl" - Mental Health Community, Italy.
CR Agostoni C, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18122608
   Anderson G, 2013, PROG NEURO-PSYCHOPH, V42, P1, DOI 10.1016/j.pnpbp.2012.10.008
   Aucoin M, 2020, NEUROPSYCHOBIOLOGY, V79, P20, DOI 10.1159/000493399
   Azzi A, 2004, BIOL CHEM, V385, P585, DOI 10.1515/BC.2004.072
   Bale TL, 2010, BIOL PSYCHIAT, V68, P314, DOI 10.1016/j.biopsych.2010.05.028
   Balu DT, 2011, NEUROSCI BIOBEHAV R, V35, P848, DOI 10.1016/j.neubiorev.2010.10.005
   Barona J, 2012, J NUTR, V142, P1626, DOI 10.3945/jn.112.162743
   Basello DA, 2015, MITOCHONDRION, V24, P56, DOI 10.1016/j.mito.2015.07.005
   Basil P, 2018, TRANSL PSYCHIAT, V8, DOI 10.1038/s41398-018-0167-x
   Bastin AR, 2020, IUBMB LIFE, V72, P1504, DOI 10.1002/iub.2286
   Batista-Jorge GC, 2020, LIFE SCI, V256, DOI 10.1016/j.lfs.2020.117962
   Bennet L, 2018, J REPROD IMMUNOL, V125, P45, DOI 10.1016/j.jri.2017.11.003
   Berridge MJ, 2018, AM J PHYSIOL-CELL PH, V314, pC135, DOI 10.1152/ajpcell.00188.2017
   Blair HA, 2020, DRUGS, V80, P417, DOI 10.1007/s40265-020-01271-6
   Block ML, 2007, NAT REV NEUROSCI, V8, P57, DOI 10.1038/nrn2038
   Brown AS, 2011, PROG NEUROBIOL, V93, P23, DOI 10.1016/j.pneurobio.2010.09.003
   Brown AS, 2010, AM J PSYCHIAT, V167, P261, DOI 10.1176/appi.ajp.2009.09030361
   Buckley PF, 2019, CURR PSYCHIAT REP, V21, DOI 10.1007/s11920-019-1050-z
   Calis Z, 2020, MINI-REV MED CHEM, V20, P1475, DOI 10.2174/1389557519666190617150051
   Cao B, 2018, PSYCHIAT RES, V259, P501, DOI 10.1016/j.psychres.2017.11.006
   Charlson FJ, 2018, SCHIZOPHRENIA BULL, V44, P1195, DOI 10.1093/schbul/sby058
   Chen XR, 2018, J NEUROINFLAMM, V15, DOI [10.1186/s12974-018-1151-3, 10.1186/s12974-017-0917-3]
   Chesworth R, 2021, FRONT NEUROSCI-SWITZ, V15, DOI 10.3389/fnins.2021.699329
   Colonna M, 2017, ANNU REV IMMUNOL, V35, P441, DOI 10.1146/annurev-immunol-051116-052358
   Correll CU, 2020, J CLIN PSYCHIAT, V81, DOI 10.4088/JCP.MS19053AH5C
   Correll CU, 2020, JAMA PSYCHIAT, V77, P349, DOI 10.1001/jamapsychiatry.2019.4379
   Crisafulli C, 2009, SHOCK, V32, P62, DOI 10.1097/SHK.0b013e31818bbad6
   Dadheech G, 2006, INDIAN J CLIN BIOCHE, V21, P34, DOI 10.1007/BF02912908
   Dalile B, 2019, NAT REV GASTRO HEPAT, V16, P461, DOI 10.1038/s41575-019-0157-3
   Dashwood RH, 2007, SEMIN CANCER BIOL, V17, P363, DOI 10.1016/j.semcancer.2007.04.001
   De Felice M, 2019, CNS NEUROSCI THER, V25, P549, DOI 10.1111/cns.13087
   Di Pierro F, 2015, EUR REV MED PHARMACO, V19, P4195
   Dienel Samuel J, 2019, Neurobiol Dis, V131, P104208, DOI 10.1016/j.nbd.2018.06.020
   Downing LE, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600347
   Erhardt S, 2017, NEUROPHARMACOLOGY, V112, P297, DOI 10.1016/j.neuropharm.2016.05.020
   Feigenson KA, 2014, NEUROSCI BIOBEHAV R, V38, P72, DOI 10.1016/j.neubiorev.2013.11.006
   Fillman SG, 2016, MOL PSYCHIATR, V21, P1090, DOI 10.1038/mp.2015.90
   Fillman SG, 2013, MOL PSYCHIATR, V18, P206, DOI 10.1038/mp.2012.110
   García-Alvarez L, 2018, EUR PSYCHIAT, V47, P50, DOI 10.1016/j.eurpsy.2017.09.007
   García-Bueno B, 2014, SCHIZOPHRENIA BULL, V40, P376, DOI 10.1093/schbul/sbt001
   Gatov E, 2017, CAN MED ASSOC J, V189, pE1177, DOI 10.1503/cmaj.161351
   Genolet Raphael, 2004, Current Drug Targets - Inflammation and Allergy, V3, P361, DOI 10.2174/1568010042634578
   Ghaderi A, 2019, BMC PSYCHIATRY, V19, DOI 10.1186/s12888-019-2059-x
   Goldsmith DR, 2018, SCHIZOPHR RES, V199, P281, DOI 10.1016/j.schres.2018.02.048
   González-Burgos G, 2005, J NEUROPHYSIOL, V93, P942, DOI 10.1152/jn.00787.2004
   Gonzalez-Burgos G, 2015, BIOL PSYCHIAT, V77, P1031, DOI 10.1016/j.biopsych.2015.03.010
   Gonzalez-Burgos G, 2011, NEURAL PLAST, V2011, DOI 10.1155/2011/723184
   Grygiel-Górniak B, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-17
   Guidotti A, 2005, PSYCHOPHARMACOLOGY, V180, P191, DOI 10.1007/s00213-005-2212-8
   Guidotti A, 2011, NEUROPHARMACOLOGY, V60, P1007, DOI 10.1016/j.neuropharm.2010.10.021
   Gupte R, 2017, GENE DEV, V31, P101, DOI 10.1101/gad.291518.116
   Han XJ, 2021, REDOX BIOL, V44, DOI 10.1016/j.redox.2021.102010
   Hao GZ, 2016, NEUROCHEM RES, V41, P1496, DOI 10.1007/s11064-016-1863-7
   Hoffman RP, 2017, CURR DIABETES REV, V13, P528, DOI 10.2174/1573399812666161201205322
   Hou CY, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20030535
   Howes OD, 2017, AM J PSYCHIAT, V174, P216, DOI 10.1176/appi.ajp.2016.16050503
   Inta D, 2017, SCHIZOPHRENIA BULL, V43, P493, DOI 10.1093/schbul/sbw088
   Iskakova M, 2015, CAN J PHYSIOL PHARM, V93, P1065, DOI 10.1139/cjpp-2014-0522
   Jha MK, 2019, NEUROSCIENTIST, V25, P227, DOI 10.1177/1073858418783959
   Jung HY, 2019, TISSUE CELL, V61, P72, DOI 10.1016/j.tice.2019.09.005
   Jungbauer A, 2014, J STEROID BIOCHEM, V139, P277, DOI 10.1016/j.jsbmb.2012.12.009
   Kaar SJ, 2020, NEUROPHARMACOLOGY, V172, DOI 10.1016/j.neuropharm.2019.107704
   Kantrowitz J, 2012, CURR OPIN PSYCHIATR, V25, P96, DOI 10.1097/YCO.0b013e32835035b2
   Kasture SB, 2015, BEHAV PHARMACOL, V26, P125, DOI 10.1097/FBP.0000000000000071
   Kaur D, 2019, INFLAMMOPHARMACOLOGY, V27, P663, DOI 10.1007/s10787-019-00580-x
   Keller WR, 2013, J PSYCHOPHARMACOL, V27, P337, DOI 10.1177/0269881112467089
   Kempuraj D, 2016, J Neurol Neurosurg Spine, V1
   Kéri S, 2017, BRAIN BEHAV IMMUN, V62, P256, DOI 10.1016/j.bbi.2016.12.011
   Kesby JP, 2017, INT J DEV NEUROSCI, V62, P1, DOI 10.1016/j.ijdevneu.2017.07.002
   Kishimoto T, 2021, LANCET PSYCHIAT, V8, P387, DOI 10.1016/S2215-0366(21)00039-0
   Kocot J, 2017, NUTRIENTS, V9, DOI 10.3390/nu9070659
   Komirishetty P, 2016, LIFE SCI, V150, P50, DOI 10.1016/j.lfs.2016.02.085
   Laskaris LE, 2016, BRIT J PHARMACOL, V173, P666, DOI 10.1111/bph.13364
   Laursen TM, 2012, CURR OPIN PSYCHIATR, V25, P83, DOI 10.1097/YCO.0b013e32835035ca
   Lewis DA, 2005, NAT REV NEUROSCI, V6, P312, DOI 10.1038/nrn1648
   Lian JM, 2016, PHARMACOL RES, V106, P51, DOI 10.1016/j.phrs.2016.02.011
   López P, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201800313
   Lupták M, 2021, WORLD J PSYCHIATR, V11, P277, DOI 10.5498/wjp.v11.i7.277
   Madera P.Z., 2019, Rev. Psiquiatr. Salud. Ment, VS18889891, P30098
   Madore C, 2016, NEURAL PLAST, V2016, DOI 10.1155/2016/3597209
   Maekawa M, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/tp.2017.182
   Maluchenko NV, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222111441
   Marinelli S, 2019, SEMIN CELL DEV BIOL, V94, P138, DOI 10.1016/j.semcdb.2019.05.017
   Marion-Letellier R, 2015, IUBMB LIFE, V67, P659, DOI 10.1002/iub.1428
   Marx W, 2017, P NUTR SOC, V76, P427, DOI 10.1017/S0029665117002026
   Matrisciano F, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms221910678
   Matrisciano F, 2016, CURR NEUROPHARMACOL, V14, P41, DOI 10.2174/1570159X13666150713174242
   Matrisciano F, 2013, NEUROPHARMACOLOGY, V68, P184, DOI 10.1016/j.neuropharm.2012.04.013
   Matrisciano F, 2012, NEUROPSYCHOPHARMACOL, V37, P929, DOI 10.1038/npp.2011.274
   Mattei D, 2020, CURR TOP BEHAV NEURO, V44, P9, DOI 10.1007/7854_2018_83
   Mayne PE, 2019, TRENDS NEUROSCI, V42, P293, DOI 10.1016/j.tins.2019.01.003
   McGrath J, 2008, EPIDEMIOL REV, V30, P67, DOI 10.1093/epirev/mxn001
   McNally JM, 2013, CURR PSYCHIAT REP, V15, DOI 10.1007/s11920-012-0346-z
   Melo HM, 2019, FRONT NEUROSCI-SWITZ, V13, DOI 10.3389/fnins.2019.00265
   Meng TT, 2021, MOLECULES, V26, DOI 10.3390/molecules26010229
   Millan MJ, 2016, NAT REV DRUG DISCOV, V15, P485, DOI 10.1038/nrd.2016.28
   Millan MJ, 2013, NEUROPHARMACOLOGY, V68, P2, DOI 10.1016/j.neuropharm.2012.11.015
   Miodownik C, 2019, CLIN NEUROPHARMACOL, V42, P117, DOI 10.1097/WNF.0000000000000344
   Mitral S, 2017, PROG NEURO-PSYCHOPH, V78, P1, DOI 10.1016/j.pnpbp.2017.05.005
   Moghaddam B, 2012, NEUROPSYCHOPHARMACOL, V37, P4, DOI 10.1038/npp.2011.181
   Moody L, 2017, ADV NUTR, V8, P337, DOI 10.3945/an.116.014209
   Müller N, 2018, SCHIZOPHRENIA BULL, V44, P973, DOI 10.1093/schbul/sby024
   Müller N, 2012, ADV PROTEIN CHEM STR, V88, P49, DOI 10.1016/B978-0-12-398314-5.00003-9
   Na KS, 2014, PROG NEURO-PSYCHOPH, V48, P277, DOI 10.1016/j.pnpbp.2012.10.022
   Notter T, 2018, MOL PSYCHIATR, V23, P36, DOI 10.1038/mp.2017.232
   Olfson M, 2015, JAMA PSYCHIAT, V72, P1172, DOI 10.1001/jamapsychiatry.2015.1737
   Oshodi TO, 2021, MOL BIOL REP, V48, P2335, DOI 10.1007/s11033-021-06264-6
   Owen MJ, 2016, LANCET, V388, P86, DOI 10.1016/S0140-6736(15)01121-6
   Pandurangi AK, 2020, CURR TOP BEHAV NEURO, V44, P227, DOI 10.1007/7854_2019_91
   Pataky Z, 2018, OBESITY FACTS, V11, P144, DOI 10.1159/000487890
   Patrick RP, 2015, FASEB J, V29, P2207, DOI 10.1096/fj.14-268342
   Payne A, 2022, BIOMOLECULES, V12, DOI 10.3390/biom12030371
   Penner Justin D, 2007, Expert Rev Neurother, V7, P797, DOI 10.1586/14737175.7.7.797
   Pilié PG, 2019, CLIN CANCER RES, V25, P3759, DOI 10.1158/1078-0432.CCR-18-0968
   Pluta R, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19124002
   Potkin SG, 2020, NPJ SCHIZOPHR, V6, DOI [10.1038/s41537-019-0090-z, 10.1176/appi.focus.18309]
   Rosciszewski G, 2018, MOL NEUROBIOL, V55, P3875, DOI 10.1007/s12035-017-0618-z
   Royal B, 2016, SCHIZOPHRENIA BULL, V42, P1083, DOI 10.1093/schbul/sbu193
   Saha S, 2007, ARCH GEN PSYCHIAT, V64, P1123, DOI 10.1001/archpsyc.64.10.1123
   Sakamoto Y, 2014, MOL NUTR FOOD RES, V58, P718, DOI 10.1002/mnfr.201300482
   Salehi A, 2022, PSYCHIAT RES, V316, DOI 10.1016/j.psychres.2022.114737
   Samaei A, 2020, INT J NEUROPSYCHOPH, V23, P775, DOI 10.1093/ijnp/pyaa006
   Sas K, 2018, MOLECULES, V23, DOI 10.3390/molecules23010191
   Severance EG, 2016, SCHIZOPHR RES, V176, P23, DOI 10.1016/j.schres.2014.06.027
   Sheffield JM, 2018, NEUROPSYCHOL REV, V28, P509, DOI 10.1007/s11065-018-9388-2
   Solmi M, 2017, THER CLIN RISK MANAG, V13, P757, DOI 10.2147/TCRM.S117321
   Stover PJ, 2018, J INTERN MED, V284, P37, DOI 10.1111/joim.12768
   Sugai T, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2015-008720
   Tang W, 2020, BRAIN BEHAV IMMUN, V88, P529, DOI 10.1016/j.bbi.2020.04.034
   Telle-Hansen VH, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111783
   Tremolizzo L, 2005, BIOL PSYCHIAT, V57, P500, DOI 10.1016/j.biopsych.2004.11.046
   Trinko JR, 2016, ENEURO, V3, DOI 10.1523/ENEURO.0122-15.2016
   Tsai Shan-Yuan, 2018, Mol Neuropsychiatry, V3, P181, DOI 10.1159/000485565
   Tueting P, 2006, NEUROSCI BIOBEHAV R, V30, P1065, DOI 10.1016/j.neubiorev.2006.04.001
   Uhlhaas PJ, 2010, TRENDS COGN SCI, V14, P72, DOI 10.1016/j.tics.2009.12.002
   Uno Y, 2019, PSYCHIAT CLIN NEUROS, V73, P204, DOI 10.1111/pcn.12823
   Upthegrove R, 2020, CURR TOP BEHAV NEURO, V44, P49, DOI 10.1007/7854_2018_88
   van Neerven S, 2008, PROG NEUROBIOL, V85, P433, DOI 10.1016/j.pneurobio.2008.04.006
   van Os J, 2010, NATURE, V468, P203, DOI 10.1038/nature09563
   van Os J, 2009, LANCET, V374, P635, DOI [10.1016/S0140-6736(09)60995-8, 10.1016/S0140-6736(15)01121-6]
   Vancampfort D, 2017, WORLD PSYCHIATRY, V16, P308, DOI 10.1002/wps.20458
   Wada Y, 2020, EBIOMEDICINE, V62, DOI 10.1016/j.ebiom.2020.103130
   Wang J, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-017-02794-5
   Wolf SA, 2017, ANNU REV PHYSIOL, V79, P619, DOI 10.1146/annurev-physiol-022516-034406
   Woloszynowska-Fraser MU, 2020, ANNU REV NUTR, V40, P247, DOI 10.1146/annurev-nutr-122319-034227
   Woodward ND, 2005, INT J NEUROPSYCHOPH, V8, P457, DOI 10.1017/S146114570500516X
   Wynn JK, 2018, SCHIZOPHR RES, V195, P572, DOI 10.1016/j.schres.2017.09.046
   Xu F, 2019, METAB BRAIN DIS, V34, P1607, DOI 10.1007/s11011-019-00468-3
   Xu FK, 2019, PSYCHOPHARMACOLOGY, V236, P1273, DOI 10.1007/s00213-018-5136-9
   Xu MY, 2018, ACTA PHARMACOL SIN, V39, P733, DOI 10.1038/aps.2017.172
   Zhong HQ, 2020, INT J NEUROPSYCHOPH, V23, P274, DOI 10.1093/ijnp/pyaa020
   Zhou W, 2021, NEUROTOX RES, V39, P1800, DOI 10.1007/s12640-021-00426-x
   Zhu SG, 2020, PSYCHONEUROENDOCRINO, V114, DOI 10.1016/j.psyneuen.2020.104595
NR 153
TC 2
Z9 2
U1 0
U2 5
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-159X
EI 1875-6190
J9 CURR NEUROPHARMACOL
JI Curr. Neuropharmacol.
PY 2023
VL 21
IS 12
BP 2409
EP 2423
DI 10.2174/1570159X21666230322160259
PG 15
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA U8WP8
UT WOS:001087552300003
PM 36946488
OA Green Published
DA 2025-06-11
ER

PT J
AU Davis, CR
   Dearing, E
   Usher, N
   Trifiletti, S
   Zaichenko, L
   Ollen, E
   Brinkoetter, MT
   Crowell-Doom, C
   Joung, K
   Park, KH
   Mantzoros, CS
   Crowell, JA
AF Davis, Cynthia R.
   Dearing, Eric
   Usher, Nicole
   Trifiletti, Sarah
   Zaichenko, Lesya
   Ollen, Elizabeth
   Brinkoetter, Mary T.
   Crowell-Doom, Cindy
   Joung, Kyoung
   Park, Kyung Hee
   Mantzoros, Christos S.
   Crowell, Judith A.
TI Detailed assessments of childhood adversity enhance prediction of
   central obesity independent of gender, race, adult psychosocial risk and
   health behaviors
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Central obesity; Childhood adversity; Psychosocial risk factors;
   Modifiable risk factors
ID METABOLIC SYNDROME; PSYCHOLOGICAL STRESS; ADIPOSE-TISSUE; US POPULATION;
   LIFE-COURSE; ABUSE; PATHWAYS; DISEASE; AXIS; AGE
AB Objective. This study examined whether a novel indicator of overall childhood adversity, incorporating number of adversities, severity, and chronicity, predicted central obesity beyond contributions of "modifiable" risk factors including psychosocial characteristics and health behaviors in a diverse sample of midlife adults. The study also examined whether the overall adversity score (number of adversities x severity x chronicity) better predicted obesity compared to cumulative adversity (number of adversities), a more traditional assessment of childhood adversity.
   Materials/Methods. 210 Black/African Americans and White/European Americans, mean age = 45.8; +/- 3.3 years, were studied cross-sectionally. Regression analysis examined overall childhood adversity as a direct, non-modifiable risk factor for central obesity (waist hip ratio) and body mass index (BMI), with and without adjustment for established adult psychosocial risk factors (education, employment, social functioning) and heath behavior risk factors (smoking, drinking, diet, exercise).
   Results. Overall childhood adversity was an independent significant predictor of central obesity, and the relations between psychosocial and health risk factors and central obesity were not significant when overall adversity was in the model. Overall adversity was not a statistically significant predictor of BMI.
   Conclusions. Overall childhood adversity, incorporating severity and chronicity and cumulative scores, predicts central obesity beyond more contemporaneous risk factors often considered modifiable. This is consistent with early dysregulation of metabolic functioning. Findings can inform practitioners interested in the impact of childhood adversity and personalizing treatment approaches of obesity within high-risk populations. Prevention/intervention research is necessary to discover and address the underlying causes and impact of childhood adversity on metabolic functioning. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Davis, Cynthia R.; Usher, Nicole; Trifiletti, Sarah; Ollen, Elizabeth; Crowell-Doom, Cindy; Crowell, Judith A.] Judge Baker Childrens Ctr, Boston, MA 02120 USA.
   [Dearing, Eric] Boston Coll, Boston, MA USA.
   [Zaichenko, Lesya; Brinkoetter, Mary T.; Joung, Kyoung; Park, Kyung Hee; Mantzoros, Christos S.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Endocrinol Diabet & Metab, Boston, MA 02215 USA.
   [Brinkoetter, Mary T.; Joung, Kyoung] Boston Childrens Hosp, Div Newborn Med, Boston, MA USA.
   [Park, Kyung Hee] Hallym Univ, Sacred Heart Hosp, Dept Family Med, Gyeonggi Do, South Korea.
   [Mantzoros, Christos S.] Harvard Univ, Sch Med, Boston VA Healthcare Syst, Endocrinol Sect, Boston, MA USA.
   [Crowell, Judith A.] SUNY Stony Brook, Dept Psychiat & Behav Sci, Sch Med, Stony Brook, NY 11794 USA.
C3 Harvard University; Harvard University Medical Affiliates; Judge Baker's
   Children's Center; Boston College; Harvard University; Harvard
   University Medical Affiliates; Beth Israel Deaconess Medical Center;
   Harvard Medical School; Harvard University; Harvard University Medical
   Affiliates; Boston Children's Hospital; Hallym University; Harvard
   University; Harvard Medical School; Harvard University Medical
   Affiliates; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Boston Healthcare System; State University of
   New York (SUNY) System; Stony Brook University
RP Davis, CR (corresponding author), Judge Baker Childrens Ctr, 53 Parker Hill Ave, Boston, MA 02120 USA.
EM crdavis@jbcc.harvard.edu
RI Park, Kyung/AAU-7867-2020; Mantzoros, Christos/Y-2902-2019
OI Zaichenko, Lesya/0000-0001-8489-3886; Park, Kyung
   Hee/0000-0001-9806-0076; Joung, Kyoung Eun/0000-0002-5942-4241
FU National Institute of Aging [AG032030]; National Institute of Diabetes
   and Digestive and Kidney Diseases grant [81913]; Harvard Clinical and
   Translational Science Center, from the National Center for Research
   Resources [UL1 RR025758]
FX Grant Support: This study was supported by the National Institute of
   Aging, grant AG032030, and National Institute of Diabetes and Digestive
   and Kidney Diseases grant 81913. The project described was supported by
   Grant Number UL1 RR025758 Harvard Clinical and Translational Science
   Center, from the National Center for Research Resources. The content is
   solely the responsibility of the authors and does not necessarily
   represent the official views of the National Center for Research
   Resources or the National Institutes of Health.
CR Ainsworth BE, 2011, MED SCI SPORT EXER, V43, P1575, DOI 10.1249/MSS.0b013e31821ece12
   [Anonymous], 1985, ADULT ATTACHME UNPUB, DOI DOI 10.1037/T02879-000
   [Anonymous], OBESITY S1
   Baker S, 2008, BRAIN RES, V1213, P98, DOI 10.1016/j.brainres.2008.03.035
   Bentley T, 2009, OBESITY, V17, P1900, DOI 10.1038/oby.2009.160
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   BJORNTORP P, 1990, ARTERIOSCLEROSIS, V10, P493, DOI 10.1161/01.ATV.10.4.493
   BLOCK G, 1986, AM J EPIDEMIOL, V124, P453, DOI 10.1093/oxfordjournals.aje.a114416
   Brown GW, 2007, J AFFECT DISORDERS, V103, P217, DOI 10.1016/j.jad.2007.06.003
   CDC, 2012, ADV CHILDH EXP STUD
   Census U, 2012, US CENS BUR STAT COU
   Chichlowska KL, 2009, ANN EPIDEMIOL, V19, P875, DOI 10.1016/j.annepidem.2009.07.094
   D'Argenio A, 2009, PHYSIOL BEHAV, V98, P543, DOI 10.1016/j.physbeh.2009.08.010
   D'mello AP, 2006, PSYCHONEUROENDOCRINO, V31, P395, DOI 10.1016/j.psyneuen.2005.10.003
   Danese A, 2012, PHYSIOL BEHAV, V106, P29, DOI 10.1016/j.physbeh.2011.08.019
   Dedert EA, 2010, J TRAUMA STRESS, V23, P785, DOI 10.1002/jts.20584
   Ebbert JO, 2013, NUTRIENTS, V5, P498, DOI 10.3390/nu5020498
   Enders CK, 2001, STRUCT EQU MODELING, V8, P128, DOI 10.1207/S15328007SEM0801_7
   FELITTI VJ, 1993, SOUTHERN MED J, V86, P732, DOI 10.1097/00007611-199307000-00002
   Felitti VJ, 1998, AM J PREV MED, V14, P245, DOI 10.1016/S0749-3797(98)00017-8
   First MB., 2002, STRUCTURED CLIN INTE
   Flegal KM, 2007, JAMA-J AM MED ASSOC, V298, P2028, DOI 10.1001/jama.298.17.2028
   Fuemmeler BE, 2009, J TRAUMA STRESS, V22, P329, DOI 10.1002/jts.20421
   Harris PA, 2009, J BIOMED INFORM, V42, P377, DOI 10.1016/j.jbi.2008.08.010
   Hauser S.T., 1991, Adolescents and their families : paths of ego development
   HAUSER ST, 1984, CHILD DEV, V55, P195, DOI 10.2307/1129845
   Hillman JB, 2012, METABOLISM, V61, P341, DOI 10.1016/j.metabol.2011.07.009
   Koch FS, 2008, J PEDIATR-US, V153, P839, DOI 10.1016/j.jpeds.2008.06.016
   Krinsley K.E., 1996, Measurement of Stress, Trauma, and Adaptation, P160
   Kwon BJ, 2013, METABOLISM, V62, P952, DOI 10.1016/j.metabol.2013.01.006
   Kyrou I, 2006, ANN NY ACAD SCI, V1083, P77, DOI 10.1196/annals.1367.008
   Langenberg C, 2006, AM J PUBLIC HEALTH, V96, P2216, DOI 10.2105/AJPH.2004.049429
   Loucks EB, 2007, ANN EPIDEMIOL, V17, P782, DOI 10.1016/j.annepidem.2007.05.003
   Masten AS, 1999, DEV PSYCHOPATHOL, V11, P143, DOI 10.1017/S0954579499001996
   McCullough ML, 2006, PUBLIC HEALTH NUTR, V9, P152, DOI 10.1079/PHN2005938
   McCullough ML, 2002, AM J CLIN NUTR, V76, P1261, DOI 10.1093/ajcn/76.6.1261
   McEwen BS, 2013, METABOLISM, V62, pS20, DOI 10.1016/j.metabol.2012.08.020
   Michalakis K, 2013, METABOLISM, V62, P457, DOI 10.1016/j.metabol.2012.08.012
   Midei AJ, 2013, HEALTH PSYCHOL, V32, P121, DOI 10.1037/a0027891
   Miller GE, 2011, PSYCHOL SCI, V22, P1591, DOI 10.1177/0956797611419170
   Miller GE, 2011, PSYCHOL BULL, V137, P959, DOI 10.1037/a0024768
   Noll JG, 2007, PEDIATRICS, V120, pE61, DOI 10.1542/peds.2006-3058
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Parker L, 2003, DIABETIC MED, V20, P406, DOI 10.1046/j.1464-5491.2003.00949.x
   Peckett AJ, 2011, METABOLISM, V60, P1500, DOI 10.1016/j.metabol.2011.06.012
   Pervanidou P, 2012, METABOLISM, V61, P611, DOI 10.1016/j.metabol.2011.10.005
   Poliakova N, 2012, METABOLISM, V61, P1270, DOI 10.1016/j.metabol.2012.02.006
   Power C, 1997, BRIT MED BULL, V53, P210
   Remington P., 2010, Chronic Disease Epidemiology and Control
   REY JM, 1988, AM J PSYCHIAT, V145, P286
   Scott KM, 2012, BRIT J PSYCHIAT, V200, P469, DOI 10.1192/bjp.bp.111.103267
   Spencer SJ, 2011, STRESS, V14, P233, DOI 10.3109/10253890.2010.534831
   Thoits PA, 2011, J HEALTH SOC BEHAV, V52, P145, DOI 10.1177/0022146510395592
   Thomas C, 2008, PEDIATRICS, V121, pE1240, DOI 10.1542/peds.2007-2403
   Uchino BN, 2006, J BEHAV MED, V29, P377, DOI 10.1007/s10865-006-9056-5
   Umberson D, 2010, ANNU REV SOCIOL, V36, P139, DOI 10.1146/annurev-soc-070308-120011
   Vicennati V, 2009, OBESITY, V17, P1678, DOI 10.1038/oby.2009.76
   Wamala SP, 1999, DIABETES CARE, V22, P1999, DOI 10.2337/diacare.22.12.1999
   Weissman M, 1974, DEPRESSED WOMAN STUD, P289
   West D, 2012, OBESITY, V16, P1413
   Widaman K.F., 2006, MONOGR SOC RES CHILD, V71, P42, DOI [DOI 10.1111/J.1540-5834.2006.00404.X, 10.1111/j.1540-5834.2006.00404.x, DOI 10.1111/J.15405834.2006.00404.X]
NR 61
TC 51
Z9 61
U1 1
U2 42
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD FEB
PY 2014
VL 63
IS 2
BP 199
EP 206
DI 10.1016/j.metabol.2013.08.013
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA 299SF
UT WOS:000330415300007
PM 24211017
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Qiu, YN
   Zheng, Z
   Kim, H
   Yang, Z
   Zhang, G
   Shi, XY
   Sun, F
   Peng, CY
   Ding, YC
   Wang, AX
   Chen, LC
   Rajagopalan, S
   Sun, QH
   Zhang, KZ
AF Qiu, Yining
   Zheng, Ze
   Kim, Hyunbae
   Yang, Zhao
   Zhang, Gary
   Shi, Xiangyang
   Sun, Fei
   Peng, Changya
   Ding, Yuchuan
   Wang, Aixia
   Chen, Lung-Chi
   Rajagopalan, Sanjay
   Sun, Qinghua
   Zhang, Kezhong
TI Inhalation Exposure to PM2.5 Counteracts Hepatic Steatosis in
   Mice Fed High-fat Diet by Stimulating Hepatic Autophagy
SO SCIENTIFIC REPORTS
LA English
DT Article
ID AIR-POLLUTION EXPOSURE; ELEMENT-BINDING PROTEIN; STRESS;
   STEATOHEPATITIS; LIPOGENESIS; OBESITY; ACIDS
AB Air pollution is associated with the increased risk of metabolic syndrome. In this study, we performed inhalation exposure of mice fed normal chow or a high-fat diet to airborne fine particulate matters (PM2.5), and then investigated the complex effects and mechanisms of inhalation exposure to PM2.5 on hepatic steatosis, a precursor or manifestation of metabolic syndrome. Our studies demonstrated that inhalation exposure of mice fed normal chow to concentrated ambient PM2.5 repressed hepatic transcriptional regulators involved in fatty acid oxidation and lipolysis, and thus promoted hepatic steatosis. However, PM2.5 exposure relieved hepatic steatosis in high-fat diet-induced obese mice. Further investigation revealed that inhalation exposure to PM2.5 induced hepatic autophagy in mouse livers in a manner depending on the MyD88-mediated inflammatory pathway. The counteractive effect of PM2.5 exposure on high-fat diet-induced hepatic steatosis was mediated through PM2.5-induced hepatic autophagy. The findings from this study not only defined the effects and mechanisms of PM2.5 exposure in metabolic disorders, but also revealed the pleotrophic acts of an environmental stressor in a complex stress system relevant to public health.
C1 [Qiu, Yining; Zheng, Ze; Kim, Hyunbae; Yang, Zhao; Zhang, Gary; Zhang, Kezhong] Wayne State Univ, Sch Med, Ctr Mol Med & Genet, Detroit, MI 48201 USA.
   [Zhang, Kezhong] Wayne State Univ, Sch Med, Dept Microbiol Immunol & Biochem, Detroit, MI 48201 USA.
   [Peng, Changya; Ding, Yuchuan] Wayne State Univ, Sch Med, Dept Neurosurg, Detroit, MI 48201 USA.
   [Sun, Fei] Wayne State Univ, Sch Med, Dept Physiol, Detroit, MI 48201 USA.
   [Wang, Aixia; Sun, Qinghua] Ohio State Univ, Davis Heart & Lung Res Inst, Div Cardiovasc Med, Coll Med, Columbus, OH 43210 USA.
   [Sun, Qinghua] Ohio State Univ, Div Environm Hlth Sci, Coll Publ Hlth, Columbus, OH 43210 USA.
   [Rajagopalan, Sanjay] Case Western Reserve Univ, Case Cardiovasc Res Inst, Sch Med, 11100 Euclid Ave, Cleveland, OH 44106 USA.
   [Chen, Lung-Chi] NYU, Dept Environm Med, Tuxedo Pk, NY 10987 USA.
   [Qiu, Yining] Huazhong Univ Sci & Technol, Union Hosp, Dept Pediat, Tongji Med Coll, Wuhan 430022, Hubei, Peoples R China.
   [Shi, Xiangyang] Donghua Univ, Coll Chem Chem Engn & Biotechnol, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China.
C3 Wayne State University; Wayne State University; Wayne State University;
   Wayne State University; University System of Ohio; Ohio State
   University; University System of Ohio; Ohio State University; University
   System of Ohio; Case Western Reserve University; New York University;
   Huazhong University of Science & Technology; Donghua University
RP Zhang, KZ (corresponding author), Wayne State Univ, Sch Med, Ctr Mol Med & Genet, Detroit, MI 48201 USA.; Zhang, KZ (corresponding author), Wayne State Univ, Sch Med, Dept Microbiol Immunol & Biochem, Detroit, MI 48201 USA.
EM kzhang@med.wayne.edu
RI Zhang, Zhiwu/P-6156-2016; Sun, Qinghua/E-4167-2011; Shi,
   Xiangyang/A-1289-2007
OI JIANG, BIN/0009-0009-0519-2527; Yang, Zhao/0000-0002-4133-3130; Zhang,
   Kezhong/0000-0002-6062-235X; Chen, Lung Chi/0000-0003-1154-2107; Shi,
   Xiangyang/0000-0001-6785-6645; Zheng, Ze/0000-0002-4453-224X; Peng,
   Changya/0009-0004-3217-8476
FU National Institutes of Health (NIH) [DK090313, ES017829]; American Heart
   Association [0635423Z, 09GRNT2280479]; NIH [ES016588, ES017412,
   ES018900, ES019616]; National Institute of Diabetes and Digestive and
   Kidney Diseases [P30DK020572] Funding Source: NIH RePORTER; American
   Heart Association (AHA) [0635423Z] Funding Source: American Heart
   Association (AHA)
FX Portions of this work were supported by National Institutes of Health
   (NIH) grants DK090313 and ES017829 to KZ, American Heart Association
   Grants 0635423Z and 09GRNT2280479 to KZ, NIH grants ES016588, ES017412,
   and ES018900 to QS, and NIH grants ES019616 to SR. Gary Zhang is a high
   school student at the Salem High School of Michigan who was a summer
   student research volunteer at the Center for Molecular Medicine and
   Genetics of Wayne State University School of Medicine.
CR Alfaro-Moreno E, 2002, ENVIRON HEALTH PERSP, V110, P715, DOI 10.1289/ehp.02110715
   Amir M, 2011, EXPERT REV GASTROENT, V5, P159, DOI [10.1586/egh.11.4, 10.1586/EGH.11.4]
   Buzzetti E, 2016, METABOLISM, V65, P1038, DOI 10.1016/j.metabol.2015.12.012
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   Fukuo Y, 2014, HEPATOL RES, V44, P1026, DOI 10.1111/hepr.12282
   Iizuka K, 2004, P NATL ACAD SCI USA, V101, P7281, DOI 10.1073/pnas.0401516101
   Inami Y, 2011, BIOCHEM BIOPH RES CO, V412, P618, DOI 10.1016/j.bbrc.2011.08.012
   Jump DB, 2005, J NUTR, V135, P2503, DOI 10.1093/jn/135.11.2503
   Kampfrath T, 2011, CIRC RES, V108, P716, DOI 10.1161/CIRCRESAHA.110.237560
   Krämer U, 2010, ENVIRON HEALTH PERSP, V118, P1273, DOI 10.1289/ehp.0901689
   Laing S, 2010, AM J PHYSIOL-CELL PH, V299, pC736, DOI 10.1152/ajpcell.00529.2009
   Maciejczyk P, 2005, INHAL TOXICOL, V17, P189, DOI 10.1080/08958370590912743
   Mendez R, 2013, AM J TRANSL RES, V5, P224
   Musso G, 2009, PROG LIPID RES, V48, P1, DOI 10.1016/j.plipres.2008.08.001
   Nemmar A, 2002, AM J RESP CRIT CARE, V166, P998, DOI 10.1164/rccm.200110-026OC
   Postic C, 2008, J CLIN INVEST, V118, P829, DOI 10.1172/JCI34275
   Schoonjans K, 1996, J LIPID RES, V37, P907
   Settembre C, 2011, SCIENCE, V332, P1429, DOI 10.1126/science.1204592
   Singh R, 2009, NATURE, V458, P1131, DOI 10.1038/nature07976
   Sorbi D, 1999, AM J GASTROENTEROL, V94, P1018
   Soukup JM, 2001, TOXICOL APPL PHARM, V171, P20, DOI 10.1006/taap.2000.9096
   Sun Q., 2009, CIRCULATION
   Sun QH, 2005, JAMA-J AM MED ASSOC, V294, P3003, DOI 10.1001/jama.294.23.3003
   Sun QH, 2008, ARTERIOSCL THROM VAS, V28, P1760, DOI 10.1161/ATVBAHA.108.166967
   Tanida Isei, 2008, V445, P77, DOI 10.1007/978-1-59745-157-4_4
   Warner N, 2013, J IMMUNOL, V190, P3, DOI 10.4049/jimmunol.1203103
   Xu J, 1999, J BIOL CHEM, V274, P23577, DOI 10.1074/jbc.274.33.23577
   Xu XH, 2010, ARTERIOSCL THROM VAS, V30, P2518, DOI 10.1161/ATVBAHA.110.215350
   Yang L, 2010, CELL METAB, V11, P467, DOI 10.1016/j.cmet.2010.04.005
   Yorimitsu T, 2005, CELL DEATH DIFFER, V12, P1542, DOI 10.1038/sj.cdd.4401765
   Zelcer N, 2006, J CLIN INVEST, V116, P607, DOI 10.1172/JCI27883
   Zhang CB, 2012, HEPATOLOGY, V55, P1070, DOI 10.1002/hep.24783
   Zheng Z., 2015, J HEPATOL
   Zheng Z, 2016, DIABETES, V65, P3369, DOI 10.2337/db16-0298
   Zheng Z, 2013, J HEPATOL, V58, P148, DOI 10.1016/j.jhep.2012.08.009
NR 35
TC 25
Z9 26
U1 1
U2 22
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD NOV 24
PY 2017
VL 7
AR 16286
DI 10.1038/s41598-017-16490-3
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FN6OL
UT WOS:000416135000085
PM 29176715
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sun, KL
   Watson, KT
   Angal, S
   Bakkila, BF
   Gorelik, AJ
   Leslie, SM
   Rasgon, NL
   Singh, MK
AF Sun, Kevin L.
   Watson, Kathleen T.
   Angal, Sarthak
   Bakkila, Baylee F.
   Gorelik, Aaron J.
   Leslie, Sara M.
   Rasgon, Natalie L.
   Singh, Manpreet K.
TI Neural and Endocrine Correlates of Early Life Abuse in Youth With
   Depression and Obesity
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE pediatric depression; obesity; insulin resistance; early life stress;
   abuse; resting state functional connectivity; diabetes
ID STATE FUNCTIONAL CONNECTIVITY; CHILDHOOD PHYSICAL ABUSE;
   INSULIN-RESISTANCE; RECEPTOR AVAILABILITY; SOCIOECONOMIC-STATUS;
   METABOLIC SYNDROME; SOCIAL-STATUS; STRESS; ADOLESCENT; OVERWEIGHT
AB Depression and insulin resistance are becoming increasingly prevalent in younger populations. The origin and consequence of insulin resistance in depressed youth may, in part, be rooted in exposure to environmental stressors, such as early life abuse, that may lead to aberrant brain motivational networks mediating maladaptive food-seeking behaviors and insipient insulin resistance. In this paper, we aimed to investigate the impact of early life abuse on the development of insulin resistance in depressed and overweight youth aged 9 to 17 years. We hypothesized that youth with the greatest burden of early life abuse would have the highest levels of insulin resistance and corresponding aberrant reward network connectivities. To test this hypothesis, we evaluated sixty-nine depressed and overweight youth aged 9 to 17, using multimodal assessments of early life abuse, food-seeking behavior, and insulin resistance. Based on results of the Childhood Trauma Questionnaire (CTQ), we separated our study participants into two groups: 35 youth who reported high levels of the sum of emotional, physical, or sexual abuse and 34 youth who reported insignificant or no levels of any abuse. Results of an oral glucose tolerance test (OGTT) and resting state functional connectivity (RSFC), using the amygdala, insula, and nucleus accumbens (NAcc) as seed-based reward network regions of interest, were analyzed for group differences between high abuse and low abuse groups. High abuse youth exhibited differences from low abuse youth in amygdala-precuneus, NAcc-paracingulate gyrus, and NAcc-prefrontal cortex connectivities, that correlated with levels of abuse experienced. The more different their connectivity from of that of low abuse youth, the higher were their fasting glucose and glucose at OGTT endpoint. Importantly, level of abuse moderated the relation between reward network connectivity and OGTT glucose response. In contrast, low abuse youth showed hyperinsulinemia and more insulin resistance than high abuse youth, and their higher OGTT insulin areas under the curve correlated with more negative insula-precuneus connectivity. Our findings suggest distinct neural and endocrine profiles of youth with depression and obesity based on their histories of early life abuse.
C1 [Sun, Kevin L.; Watson, Kathleen T.; Angal, Sarthak; Bakkila, Baylee F.; Gorelik, Aaron J.; Leslie, Sara M.; Rasgon, Natalie L.; Singh, Manpreet K.] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
C3 Stanford University
RP Singh, MK (corresponding author), Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
EM mksingh@stanford.edu
RI Rasgon, Natalie/ABH-9813-2020; Gorelik, Aaron/AAV-1922-2020; Singh,
   Manpreet/L-1068-2014
OI Bakkila, Baylee/0000-0001-9506-1831; Gorelik, Aaron/0000-0002-2589-1220;
   Leslie, Sara/0000-0002-5557-4293; Sun, Kevin Lee/0000-0003-1904-6570;
   Singh, Manpreet/0000-0002-4373-3293
FU National Institute of Mental Health [R01MH106581]; National Institute of
   Aging [R01AG050345]
FX This work was supported by the National Institute of Mental Health
   (R01MH106581) and the National Institute of Aging (R01AG050345).
CR Adam TC, 2010, J CLIN ENDOCR METAB, V95, P4729, DOI 10.1210/jc.2010-0322
   Amft M, 2015, BRAIN STRUCT FUNCT, V220, P1031, DOI 10.1007/s00429-013-0698-0
   Bacchini D, 2017, CHILD OBES, V13, P242, DOI 10.1089/chi.2016.0139
   Baldwin JR, 2016, PSYCHOSOM MED, V78, P1094, DOI 10.1097/PSY.0000000000000388
   Bauldry S, 2012, SOC SCI MED, V75, P1311, DOI 10.1016/j.socscimed.2012.05.017
   Bernstein DP, 2003, CHILD ABUSE NEGLECT, V27, P169, DOI 10.1016/S0145-2134(02)00541-0
   Bremner JD, 2007, NEUROIMAG CLIN N AM, V17, P523, DOI 10.1016/j.nic.2007.07.003
   Brown J, 1999, J AM ACAD CHILD PSY, V38, P1490, DOI 10.1097/00004583-199912000-00009
   Caravaggio F, 2016, EUR NEUROPSYCHOPHARM, V26, P644, DOI 10.1016/j.euroneuro.2016.02.010
   Caravaggio F, 2015, INT J NEUROPSYCHOPH, V18, DOI 10.1093/ijnp/pyv014
   Carpenter LL, 2011, PSYCHOPHARMACOLOGY, V214, P367, DOI 10.1007/s00213-010-2007-4
   Carpenter LL, 2009, BIOL PSYCHIAT, V66, P69, DOI 10.1016/j.biopsych.2009.02.030
   Cecil CAM, 2017, CHILD ABUSE NEGLECT, V63, P106, DOI 10.1016/j.chiabu.2016.11.024
   Cisler JM, 2013, PSYCHOL MED, V43, P507, DOI 10.1017/S0033291712001390
   Copeland WE, 2014, P NATL ACAD SCI USA, V111, P7570, DOI 10.1073/pnas.1323641111
   Coveleskie K, 2015, NUTR DIABETES, V5, DOI 10.1038/nutd.2014.45
   Cullen KR, 2014, JAMA PSYCHIAT, V71, P1138, DOI 10.1001/jamapsychiatry.2014.1087
   D'Angeli MA, 2010, ARCH PEDIAT ADOL MED, V164, P732, DOI 10.1001/archpediatrics.2010.115
   Dennison MJ, 2016, J ABNORM PSYCHOL, V125, P1201, DOI 10.1037/abn0000215
   DeWitt SJ, 2015, AM J DRUG ALCOHOL AB, V41, P374, DOI 10.3109/00952990.2015.1049701
   Dillon DG, 2009, BIOL PSYCHIAT, V66, P206, DOI 10.1016/j.biopsych.2009.02.019
   Du L, 2018, TRANSL PSYCHIAT, V7, DOI 10.1038/s41398-017-0005-6
   Egerton A, 2016, SCHIZOPHR RES, V176, P171, DOI 10.1016/j.schres.2016.06.005
   Eisenstein SA, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0133621
   Eisenstein SA, 2015, SCI REP-UK, V5, DOI 10.1038/srep11283
   Ewing SWF, 2017, BRAIN IMAGING BEHAV, V11, P925, DOI 10.1007/s11682-016-9564-z
   Figlewicz DP, 2016, BRAIN RES, V1645, P68, DOI 10.1016/j.brainres.2015.12.041
   Forbes EE, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094640
   Golden SH, 2008, JAMA-J AM MED ASSOC, V299, P2751, DOI 10.1001/jama.299.23.2751
   Guo J, 2014, MOL PSYCHIATR, V19, P1078, DOI 10.1038/mp.2014.102
   Gupta A, 2015, NEUROIMAGE-CLIN, V7, P506, DOI 10.1016/j.nicl.2015.01.005
   Hannon TS, 2014, PEDIATR OBES, V9, pE103, DOI 10.1111/ijpo.237
   Harkin B, 2011, FRONT PSYCHOL, V2, DOI [10.3389/fpsyg.2011.00078, 10.3389/fpsyt.2011.00037]
   Herringa RJ, 2013, P NATL ACAD SCI USA, V110, P19119, DOI 10.1073/pnas.1310766110
   Heshmati Mitra, 2015, Curr Behav Neurosci Rep, V2, P146
   Hollingshead A., 2011, Four factor index of social status, V8, P21
   Holt RIG, 2014, CURR DIABETES REP, V14, DOI 10.1007/s11892-014-0491-3
   Hoshi E, 2006, NEUROSCI RES, V54, P73, DOI 10.1016/j.neures.2005.10.013
   Humphreys KL, 2015, NEUROPSYCHOPHARMACOL, V40, P154, DOI 10.1038/npp.2014.165
   Hymowitz G, 2017, EAT BEHAV, V26, P27, DOI 10.1016/j.eatbeh.2016.12.010
   Iadipaolo AS, 2017, BEHAV BRAIN RES, V333, P135, DOI 10.1016/j.bbr.2017.06.039
   Janak PH, 2015, NATURE, V517, P284, DOI 10.1038/nature14188
   Jastreboff AM, 2013, DIABETES CARE, V36, P394, DOI 10.2337/dc12-1112
   Jenkinson M, 2002, NEUROIMAGE, V17, P825, DOI 10.1006/nimg.2002.1132
   Kahathuduwa CN, 2018, APPETITE, V120, P431, DOI 10.1016/j.appet.2017.09.025
   Kan C, 2013, DIABETES CARE, V36, P480, DOI 10.2337/dc12-1442
   Kaufman J, 1997, J AM ACAD CHILD PSY, V36, P980, DOI 10.1097/00004583-199707000-00021
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kawamichi H, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-20074-0
   King LS, 2019, DEV PSYCHOPATHOL, V31, P643, DOI 10.1017/S0954579418000184
   Kircher TTJ, 2000, COGNITIVE BRAIN RES, V10, P133, DOI 10.1016/S0926-6410(00)00036-7
   Kullmann S, 2012, HUM BRAIN MAPP, V33, P1052, DOI 10.1002/hbm.21268
   Lips MA, 2014, AM J CLIN NUTR, V100, P524, DOI 10.3945/ajcn.113.080671
   Liu S, 2013, NUTR DIABETES, V3, DOI 10.1038/nutd.2013.38
   Lou HC, 2004, P NATL ACAD SCI USA, V101, P6827, DOI 10.1073/pnas.0400049101
   Martinez D, 2010, BIOL PSYCHIAT, V67, P275, DOI 10.1016/j.biopsych.2009.07.037
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Matuskey D, 2015, DRUG ALCOHOL DEPEN, V154, P167, DOI 10.1016/j.drugalcdep.2015.06.039
   Mehta MA, 2010, J COGNITIVE NEUROSCI, V22, P2316, DOI 10.1162/jocn.2009.21394
   Merikangas KR, 2010, J AM ACAD CHILD PSY, V49, P980, DOI 10.1016/j.jaac.2010.05.017
   Mietus-Snyder ML, 2008, ANNU REV MED, V59, P147, DOI 10.1146/annurev.med.59.103106.105628
   Miller AB, 2018, J ABNORM PSYCHOL, V127, P160, DOI 10.1037/abn0000331
   Moreno-Lopez L, 2016, NEUROIMAGE-CLIN, V12, P262, DOI 10.1016/j.nicl.2016.07.005
   Mynard H, 2000, AGGRESSIVE BEHAV, V26, P169, DOI 10.1002/(SICI)1098-2337(2000)26:2<169::AID-AB3>3.0.CO;2-A
   Nemeroff CB, 2016, NEURON, V89, P892, DOI 10.1016/j.neuron.2016.01.019
   Nusslock R, 2016, BIOL PSYCHIAT, V80, P23, DOI 10.1016/j.biopsych.2015.05.017
   Page KA, 2013, JAMA-J AM MED ASSOC, V309, P63, DOI 10.1001/jama.2012.116975
   Paquola C, 2017, HUM BRAIN MAPP, V38, P2709, DOI 10.1002/hbm.23554
   Pearson S, 2010, DIABETES CARE, V33, P1128, DOI 10.2337/dc09-1940
   Pervanidou P, 2012, METABOLISM, V61, P611, DOI 10.1016/j.metabol.2011.10.005
   Pervanidou P, 2011, INT J PEDIATR OBES, V6, P21, DOI 10.3109/17477166.2011.615996
   PETERSEN AC, 1988, J YOUTH ADOLESCENCE, V17, P117, DOI 10.1007/BF01537962
   Power JD, 2014, NEUROIMAGE, V84, P320, DOI 10.1016/j.neuroimage.2013.08.048
   POZNANSKI EO, 1984, J AM ACAD CHILD PSY, V23, P191, DOI 10.1097/00004583-198403000-00011
   Psychological Corporation, 1999, WECHSLER ABBREVIATED
   Quevedo K, 2018, J AFFECT DISORDERS, V229, P22, DOI 10.1016/j.jad.2017.12.023
   Rich-Edwards JW, 2010, AM J PREV MED, V39, P529, DOI 10.1016/j.amepre.2010.09.007
   Rincón-Cortés M, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.205
   RIZZA RA, 1982, J CLIN ENDOCR METAB, V54, P131, DOI 10.1210/jcem-54-1-131
   Rohde P, 2008, CHILD ABUSE NEGLECT, V32, P878, DOI 10.1016/j.chiabu.2007.11.004
   Russo SJ, 2013, NAT REV NEUROSCI, V14, P609, DOI 10.1038/nrn3381
   Schellekens H, 2012, PHARMACOL THERAPEUT, V135, P316, DOI 10.1016/j.pharmthera.2012.06.004
   Shields ME, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-3491-1
   Shomaker LB, 2015, PSYCHOSOM MED, V77, P938, DOI 10.1097/PSY.0000000000000230
   Siddiqui A, 2015, STRESS, V18, P498, DOI 10.3109/10253890.2015.1067677
   Singh MK, 2019, HORM BEHAV, V108, P73, DOI 10.1016/j.yhbeh.2018.03.009
   Smith SM, 2002, HUM BRAIN MAPP, V17, P143, DOI 10.1002/hbm.10062
   Smoski MJ, 2011, PSYCHIAT RES-NEUROIM, V194, P263, DOI 10.1016/j.pscychresns.2011.06.012
   Springer KW, 2007, CHILD ABUSE NEGLECT, V31, P517, DOI 10.1016/j.chiabu.2007.01.003
   Stouffer MA, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms9543
   Stumvoll M, 2000, DIABETES CARE, V23, P295, DOI 10.2337/diacare.23.3.295
   STUNKARD AJ, 1985, J PSYCHOSOM RES, V29, P71, DOI 10.1016/0022-3999(85)90010-8
   Teicher MH, 2014, BIOL PSYCHIAT, V76, P297, DOI 10.1016/j.biopsych.2013.09.016
   ter Horst KW, 2018, SCI TRANSL MED, V10, DOI 10.1126/scitranslmed.aar3752
   Thapar A, 2012, LANCET, V379, P1056, DOI 10.1016/S0140-6736(11)60871-4
   Thayer RE, 2016, PROG BRAIN RES, V224, P305, DOI 10.1016/bs.pbr.2015.07.020
   Tippett N, 2014, AM J PUBLIC HEALTH, V104, pE48, DOI 10.2105/AJPH.2014.301960
   Turchiano M, 2012, ARCH PEDIAT ADOL MED, V166, P1030, DOI 10.1001/archpediatrics.2012.1263
   van der Werff SJA, 2013, PSYCHOL MED, V43, P1825, DOI 10.1017/S0033291712002942
   van Geel M, 2014, INT J OBESITY, V38, P1263, DOI 10.1038/ijo.2014.117
   Veer IM, 2012, PSYCHONEUROENDOCRINO, V37, P1039, DOI 10.1016/j.psyneuen.2011.12.001
   Wallace DL, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0096319
   Wiers CE, 2016, NEUROSCI LETT, V617, P27, DOI 10.1016/j.neulet.2016.01.056
   Williams DB, 2015, J RECEPT SIG TRANSD, V35, P516, DOI 10.3109/10799893.2014.960935
   Yau PL, 2012, PEDIATRICS, V130, pE856, DOI 10.1542/peds.2012-0324
   Young CB, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.80
NR 106
TC 12
Z9 12
U1 2
U2 23
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD DEC 21
PY 2018
VL 9
AR 721
DI 10.3389/fpsyt.2018.00721
PG 14
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HF2QX
UT WOS:000454082600001
PM 30622489
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Barbosa, BJAP
   de Souza-Talarico, JN
   de Jesus, MCF
   Mota, GPS
   de Oliveira, MO
   Cassimiro, L
   Avolio, IMB
   Trés, ES
   Borges, CR
   Teixeira, TBM
   Brucki, SMD
AF Barbosa, Breno Jose Alencar Pires
   de Souza-Talarico, Juliana Nery
   de Jesus, Maria Clara Ferreira
   Mota, Gabriel Paz Souza
   de Oliveira, Maira Okada
   Cassimiro, Luciana
   Avolio, Isabella Maria Bello
   Tres, Eduardo Sturzeneker
   Borges, Conrado Regis
   Teixeira, Thiago Bezerra Moraes
   Brucki, Sonia Maria Dozzi
TI Allostatic load measures in older adults with subjective cognitive
   decline and mild cognitive impairment: A cross-sectional analysis from
   the Brazilian Memory and Aging Study
SO CLINICAL NEUROLOGY AND NEUROSURGERY
LA English
DT Article
DE Physiological stress; Cognitive dysfunction; Alzheimer's disease;
   Allostasis; Metabolic syndrome; Aging
ID PERCEIVED STRESS SCALE; ALZHEIMERS-DISEASE; PHYSIOLOGICAL DYSREGULATION;
   DEMENTIA PREVENTION; METABOLIC SYNDROME; BRAIN; CORTISOL; RISK;
   INTERVENTION; ASSOCIATION
AB Introduction: An increasing body of research suggests that stress and allostatic load are related to cognitive dysfunction and neurodegeneration. Objectives: to determine the relationship between allostatic load (AL) and cognitive status in older adults classified with subjective cognitive decline (SCD) and mild cognitive impairment (MCI). Methodology: Using the Brazilian Memory and Aging Study (BRAMS) database, we analyzed data from 57 older adults with SCD and MCI. Blood neuroendocrine (cortisol, DHEA-s), inflammatory (C -reactive protein, fibrinogen), metabolic (HbA1c, HDL-cholesterol, total cholesterol, creatinine), and cardiovascular (blood pressure, waist/hip ratio) were transformed into an AL index. Results: Despite a significant difference in the univariate analysis between waist/hip ratio (0.94 in the MCI group vs. 0, 88 in the SCD group, p = 0.03), total cholesterol levels (194 vs. 160, p = 0.02), and AL index (36.9 % in the MCI group vs. 27.2 % in the SCD group, p = 0.04), AL was not associated with SCD or MCI in the multivariate analysis. Conclusion: Our data suggest that different profiles of AL in MCI compared to individuals with SCD could be due to cofounding factors. These findings need to be confirmed in longitudinal studies investigating profiles of AL changes at preclinical and prodromal stages of Alzheimer's disease.
C1 [Barbosa, Breno Jose Alencar Pires; de Oliveira, Maira Okada; Cassimiro, Luciana; Avolio, Isabella Maria Bello; Tres, Eduardo Sturzeneker; Borges, Conrado Regis; Teixeira, Thiago Bezerra Moraes; Brucki, Sonia Maria Dozzi] Univ Sao Paulo, Sch Med, Dept Neurol, Sao Paulo, Brazil.
   [Barbosa, Breno Jose Alencar Pires] Univ Fed Pernambuco, Ctr Ciencias Med, Area Acad Neuropsiquiatria, Recife, Brazil.
   [de Souza-Talarico, Juliana Nery; de Jesus, Maria Clara Ferreira] Univ Sao Paulo, Sch Nursing, Dept Med Surg Nursing, Sao Paulo, Brazil.
   [de Souza-Talarico, Juliana Nery] Univ Iowa, Coll Nursing, Iowa City, IA USA.
   [Mota, Gabriel Paz Souza] Univ Fed Juiz de Fora, Juiz De Fora, Brazil.
   [Barbosa, Breno Jose Alencar Pires] Univ Fed Pernambuco, Dept Fis, Hosp Clin, Ave Prof Moraes Rego 1235 Bloco A Terreo Cidade Un, BR-50670901 Recife, PE, Brazil.
C3 Universidade de Sao Paulo; Universidade Federal de Pernambuco;
   Universidade de Sao Paulo; University of Iowa; Universidade Federal de
   Juiz de Fora; Universidade Federal de Pernambuco
RP Barbosa, BJAP (corresponding author), FMUSP, Div Clin Neurol, Hosp Clin, Ave Dr Eneas De Carvalho Aguiar 255,5 Andar,Sala 5, BR-05403900 Sao Paulo, SP, Brazil.; Barbosa, BJAP (corresponding author), Univ Fed Pernambuco, Dept Fis, Hosp Clin, Ave Prof Moraes Rego 1235 Bloco A Terreo Cidade Un, BR-50670901 Recife, PE, Brazil.
EM breno.pbarbosa@ufpe.br; juliana-desouzatalarico@uiowa.edu;
   mariaclarajesus@usp.br; ga.paz.mota@gmail.com; maira.okada@gmail.com;
   lucassimiro@terra.com.br; isabella.avolio@hotmail.com;
   eduardotres.neuro@gmail.com; conradoborges@outlook.com;
   thiagobmteixeira@gmail.com; sonia.brucki@gmail.com
RI Maria Dozzi Brucki, Sonia/HKV-7483-2023; Talarico,
   Juliana/ABA-8650-2020; de Oliveira, Maira/P-1671-2019; Alencar Pires
   Barbosa, Breno Jose/J-6969-2013; Tres, Eduardo/D-3769-2015
OI Alencar Pires Barbosa, Breno Jose/0000-0003-4333-2024; Paz Souza Mota,
   Gabriel/0000-0002-6872-1432; Tres, Eduardo/0000-0002-6112-7190
FU FAPESP [2021/01459-3, 2012/50239- 6, 2017/10033-4]; Formas [2021-01459]
   Funding Source: Formas
FX This research is funded by the agency FAPESP (Grants 2012/50239- 6,
   2017/10033-4 and 2021/01459-3) .
CR Adedeji DO, 2023, BRAIN BEHAV IMMUN-HL, V28, DOI 10.1016/j.bbih.2023.100592
   Akbaraly TN, 2010, DIABETES CARE, V33, P84, DOI 10.2337/dc09-1218
   Akrivos J, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2019-035847
   Albert MarilynS., DIAGNOSIS MILD COGNI
   Alexopoulos P, 2006, DEMENT GERIATR COGN, V22, P27, DOI 10.1159/000093101
   Almeida OP, 1999, ARQ NEURO-PSIQUIAT, V57, P421, DOI 10.1590/S0004-282X1999000300013
   [Anonymous], Criterio Brasil
   Barbosa BJAP, 2019, NEUROLOGY, V93, P685, DOI 10.1212/WNL.0000000000008257
   Bertola L, 2023, J GERONTOL A-BIOL, V78, P1060, DOI 10.1093/gerona/glad025
   Beydoun HA, 2023, J ALZHEIMERS DIS, V92, P425, DOI 10.3233/JAD-220888
   Booth T, 2015, NEUROBIOL AGING, V36, P1390, DOI 10.1016/j.neurobiolaging.2014.12.020
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Cole JH, 2018, MOL PSYCHIATR, V23, P1385, DOI 10.1038/mp.2017.62
   Csernansky JG, 2006, AM J PSYCHIAT, V163, P2164, DOI 10.1176/appi.ajp.163.12.2164
   D'Amico D, 2020, PSYCHONEUROENDOCRINO, V121, DOI 10.1016/j.psyneuen.2020.104849
   De Felice FG, 2022, NAT REV NEUROSCI, V23, P215, DOI 10.1038/s41583-022-00558-9
   de Souza-Talarico JN, 2020, PSYCHONEUROENDOCRINO, V115, DOI 10.1016/j.psyneuen.2020.104601
   de Souza-Talarico JN, 2020, STRESS HEALTH, V36, P19, DOI 10.1002/smi.2906
   Dubois B, 2016, ALZHEIMERS DEMENT, V12, P292, DOI 10.1016/j.jalz.2016.02.002
   Echouffo-Tcheugui JB, 2018, NEUROLOGY, V91, pE1961, DOI 10.1212/WNL.0000000000006549
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hassenstab JJ, 2010, DEMENT GERIATR COGN, V29, P356, DOI 10.1159/000296071
   Holleman J, 2022, BMJ NEUROL OPEN, V4, DOI 10.1136/bmjno-2022-000344
   Hou YJ, 2019, NAT REV NEUROL, V15, P565, DOI 10.1038/s41582-019-0244-7
   Jack CR Jr, 2018, ALZHEIMERS DEMENT, V14, P535, DOI 10.1016/j.jalz.2018.02.018
   Jak AJ, 2016, J INT NEUROPSYCH SOC, V22, P937, DOI 10.1017/S1355617716000199
   Jessen F, 2020, LANCET NEUROL, V19, P271, DOI 10.1016/S1474-4422(19)30368-0
   Juster RP, 2010, NEUROSCI BIOBEHAV R, V35, P2, DOI 10.1016/j.neubiorev.2009.10.002
   Karlamangla AS, 2014, NEUROBIOL AGING, V35, P387, DOI 10.1016/j.neurobiolaging.2013.07.028
   Lenart-Bugla M, 2022, PSYCHONEUROENDOCRINO, V145, DOI 10.1016/j.psyneuen.2022.105917
   Livingston G, 2017, LANCET, V390, P2673, DOI 10.1016/S0140-6736(17)31363-6
   Livingston G, 2020, LANCET, V396, P413, DOI 10.1016/S0140-6736(20)30367-6
   Luft CD, 2007, REV SAUDE PUBL, V41, P606, DOI 10.1590/S0034-89102007000400015
   Lupien SJ, 2007, BRAIN COGNITION, V65, P209, DOI 10.1016/j.bandc.2007.02.007
   Lupien SJ, 2018, FRONT NEUROENDOCRIN, V49, P91, DOI 10.1016/j.yfrne.2018.02.001
   Lupien SJ, 2009, NAT REV NEUROSCI, V10, P434, DOI 10.1038/nrn2639
   Matos Tatiane Martins, 2019, Dement. neuropsychol., V13, P11, DOI 10.1590/1980-57642018dn13-010002
   McCall AL, 2005, NEUROBIOL AGING, V26, pS70, DOI 10.1016/j.neurobiolaging.2005.08.009
   McEwen BS, 1998, ANN NY ACAD SCI, V840, P33, DOI 10.1111/j.1749-6632.1998.tb09546.x
   McKim DB, 2016, J NEUROSCI, V36, P2590, DOI 10.1523/JNEUROSCI.2394-15.2016
   Norton S, 2014, LANCET NEUROL, V13, P788, DOI 10.1016/S1474-4422(14)70136-X
   Ouanes S, 2019, FRONT AGING NEUROSCI, V11, DOI 10.3389/fnagi.2019.00043
   Petersen RC, 2018, NEUROLOGY, V90, P126, DOI 10.1212/WNL.0000000000004826
   Reis RS, 2010, J HEALTH PSYCHOL, V15, P107, DOI 10.1177/1359105309346343
   Ritchie SJ, 2017, BRAIN STRUCT FUNCT, V222, P3477, DOI 10.1007/s00429-017-1414-2
   Sachdev PS, 2014, NAT REV NEUROL, V10, P634, DOI 10.1038/nrneurol.2014.181
   Seeman TE, 2001, P NATL ACAD SCI USA, V98, P4770, DOI 10.1073/pnas.081072698
   Segura B, 2009, NEUROSCI LETT, V462, P49, DOI 10.1016/j.neulet.2009.06.071
   Seplaki CL, 2006, DEMOGRAPHY, V43, P165, DOI 10.1353/dem.2006.0009
   Seplaki CL, 2005, EXP GERONTOL, V40, P438, DOI 10.1016/j.exger.2005.03.002
   Simpson JR, 2014, J AM ACAD PSYCHIATRY, V42, P159
   Smid J., 2022, Neuropsychol, V16, P1, DOI [10.1590/ 1980-5764-DN-2022-S101PT, DOI 10.1590/1980-5764-DN-2022-S101PT]
   Souza-Talarico JN, 2010, J ALZHEIMERS DIS, V19, P839, DOI 10.3233/JAD-2010-1282
   Stuart KE, 2020, J ALZHEIMERS DIS, V78, P335, DOI 10.3233/JAD-191096
   Studart Neto Adalberto, 2016, Dement. neuropsychol., V10, P170, DOI 10.1590/S1980-5764-2016DN1003002
   Udeh-Momoh CT, 2019, J ALZHEIMERS DIS, V70, P551, DOI 10.3233/JAD-181030
   Winblad B, 2004, J INTERN MED, V256, P240, DOI 10.1111/j.1365-2796.2004.01380.x
   Wolf OT, 2002, PSYCHONEUROENDOCRINO, V27, P777, DOI 10.1016/S0306-4530(01)00079-8
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
   Zsoldos E, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-24398-9
NR 60
TC 0
Z9 0
U1 5
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0303-8467
EI 1872-6968
J9 CLIN NEUROL NEUROSUR
JI Clin. Neurol. Neurosurg.
PD AUG
PY 2024
VL 243
AR 108365
DI 10.1016/j.clineuro.2024.108365
EA JUN 2024
PG 7
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA XT0H7
UT WOS:001263806500001
PM 38852227
DA 2025-06-11
ER

PT J
AU Miraldi, ER
   Sharfi, H
   Friedline, RH
   Johnson, H
   Zhang, T
   Lau, KS
   Ko, HJ
   Curran, TG
   Haigis, KM
   Yaffe, MB
   Bonneau, R
   Lauffenburger, DA
   Kahn, BB
   Kim, JK
   Neel, BG
   Saghatelian, A
   White, FM
AF Miraldi, Emily R.
   Sharfi, Hadar
   Friedline, Randall H.
   Johnson, Hannah
   Zhang, Tejia
   Lau, Ken S.
   Ko, Hwi Jin
   Curran, Timothy G.
   Haigis, Kevin M.
   Yaffe, Michael B.
   Bonneau, Richard
   Lauffenburger, Douglas A.
   Kahn, Barbara B.
   Kim, Jason K.
   Neel, Benjamin G.
   Saghatelian, Alan
   White, Forest M.
TI Molecular network analysis of phosphotyrosine and lipid metabolism in
   hepatic PTP1b deletion mice
SO INTEGRATIVE BIOLOGY
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; LEAST-SQUARES REGRESSION; LIVER-SPECIFIC
   DELETION; TYROSINE PHOSPHORYLATION; INSULIN SENSITIVITY;
   MASS-SPECTROMETRY; LIGAND-BINDING; FATTY LIVER; PROTEIN; OBESITY
AB Metabolic syndrome describes a set of obesity-related disorders that increase diabetes, cardiovascular, and mortality risk. Studies of liver-specific protein-tyrosine phosphatase 1b (PTP1b) deletion mice (L-PTP1b(-/-)) suggest that hepatic PTP1b inhibition would mitigate metabolic-syndrome through amelioration of hepatic insulin resistance, endoplasmic-reticulum stress, and whole-body lipid metabolism. However, the altered molecular-network states underlying these phenotypes are poorly understood. We used mass spectrometry to quantify protein-phosphotyrosine network changes in L-PTP1b(-/-) mouse livers relative to control mice on normal and high-fat diets. We applied a phosphosite-set-enrichment analysis to identify known and novel pathways exhibiting PTP1b- and diet-dependent phosphotyrosine regulation. Detection of a PTP1b-dependent, but functionally uncharacterized, set of phosphosites on lipid-metabolic proteins motivated global lipidomic analyses that revealed altered polyunsaturated-fatty-acid (PUFA) and triglyceride metabolism in L-PTP1b(-/-) mice. To connect phosphosites and lipid measurements in a unified model, we developed a multivariate-regression framework, which accounts for measurement noise and systematically missing proteomics data. This analysis resulted in quantitative models that predict roles for phosphoproteins involved in oxidation-reduction in altered PUFA and triglyceride metabolism.
C1 [Miraldi, Emily R.] MIT, Cambridge, MA 02138 USA.
   [Miraldi, Emily R.; Sharfi, Hadar; Johnson, Hannah; Lau, Ken S.; Curran, Timothy G.; Yaffe, Michael B.; White, Forest M.] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA.
   [Friedline, Randall H.; Ko, Hwi Jin; Kim, Jason K.] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA.
   [Friedline, Randall H.; Ko, Hwi Jin; Kim, Jason K.] Univ Massachusetts, Sch Med, Dept Med, Div Endocrinol Metab & Diabet, Worcester, MA 01605 USA.
   [Johnson, Hannah; Lau, Ken S.; Curran, Timothy G.; Lauffenburger, Douglas A.; White, Forest M.] MIT, Dept Biol Engn, Cambridge, MA 02139 USA.
   [Zhang, Tejia; Saghatelian, Alan] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA.
   [Lau, Ken S.; Haigis, Kevin M.] Massachusetts Gen Hosp, Ctr Canc Res, Mol Pathol Unit, Charlestown, MA 02129 USA.
   [Lau, Ken S.; Haigis, Kevin M.] Massachusetts Gen Hosp, Ctr Syst Biol, Charlestown, MA 02129 USA.
   [Haigis, Kevin M.] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA.
   [Bonneau, Richard] NYU, Ctr Genom & Syst Biol, New York, NY 10003 USA.
   [Kahn, Barbara B.] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Endocrinol Diabet & Metab,Dept Med, Boston, MA 02215 USA.
   [Neel, Benjamin G.] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 2M9, Canada.
   [Neel, Benjamin G.] Univ Hlth Network, Ontario Canc Inst, Campbell Family Canc Res Inst, Toronto, ON M5G 1K7, Canada.
   [Neel, Benjamin G.] Univ Hlth Network, Princess Margaret Hosp, Toronto, ON M5G 1K7, Canada.
C3 Massachusetts Institute of Technology (MIT); Massachusetts Institute of
   Technology (MIT); University of Massachusetts System; University of
   Massachusetts Worcester; University of Massachusetts System; University
   of Massachusetts Worcester; Massachusetts Institute of Technology (MIT);
   Harvard University; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Harvard University; Harvard
   University Medical Affiliates; Massachusetts General Hospital; Harvard
   University; Harvard Medical School; New York University; Harvard
   University; Harvard Medical School; Harvard University Medical
   Affiliates; Beth Israel Deaconess Medical Center; University of Toronto;
   University of Toronto; University Health Network Toronto; University of
   Toronto; University Health Network Toronto; Princess Margaret Cancer
   Centre
RP Miraldi, ER (corresponding author), MIT, Cambridge, MA 02138 USA.
EM fwhite@mit.edu
RI Lau, Ken/I-7958-2019; Bonneau, Richard/ABD-6737-2021
OI Reeves, Hannah/0000-0003-3473-3782; Lau, Ken/0000-0001-8438-0319; White,
   Forest/0000-0002-1545-1651; Kim, Jason/0000-0002-7185-042X
FU Pfizer Inc.; NIH [5R24DK090963, U54-CA112967, CA49152 R37,
   R01-DK080756]; UMass Mouse Metabolic Phenotyping Center Grant
   [U24-DK093000]; National Science Foundation; Ontario Ministry of Health
   and Long Term Care; Princess Margaret Hospital Foundation
FX We thank Ms Angel Sing (OCI) for generating the mice for this study,
   Edwin Homan (Harvard) for help with fatty acid separation techniques,
   Robert Gerszten (Mass General Hospital) for helpful advice, and Kristen
   Naegle (Washington University) for assistance with phosphosite
   annotations in PTMScout. This work was supported by a grant from Pfizer
   Inc., NIH grants 5R24DK090963, U54-CA112967, CA49152 R37 (B.G.N.), and
   R01-DK080756 (J.K.K.), and the UMass Mouse Metabolic Phenotyping Center
   Grant (U24-DK093000) (J.K.K.). E. R. M. has been supported by a Graduate
   Research Fellowship from the National Science Foundation. Work in
   B.G.N.'s lab is partially supported by the Ontario Ministry of Health
   and Long Term Care and the Princess Margaret Hospital Foundation.
CR Agouni A, 2011, BIOCHEM J, V438, P369, DOI 10.1042/BJ20110373
   [Anonymous], 2009, Multiple Imputation for Nonresponse in Surveys
   Biddinger SB, 2006, ANNU REV PHYSIOL, V68, P123, DOI 10.1146/annurev.physiol.68.040104.124723
   Cohen P., 1995, Empirical Methods for Artificial Intelligence
   Coleman RA, 2004, PROG LIPID RES, V43, P134, DOI 10.1016/S0163-7827(03)00051-1
   Delibegovic M, 2009, DIABETES, V58, P590, DOI 10.2337/db08-0913
   Elchebly M, 1999, SCIENCE, V283, P1544, DOI 10.1126/science.283.5407.1544
   Eriksson L., 2006, UMETRICS
   Faergeman NJ, 1996, BIOCHEMISTRY-US, V35, P14118, DOI 10.1021/bi960545z
   Fan J, 2011, MOL CELL BIOL, V31, P4938, DOI 10.1128/MCB.06120-11
   Feng JH, 2010, AM J PHYSIOL-CELL PH, V298, pC740, DOI 10.1152/ajpcell.00310.2009
   Frey BJ, 2007, SCIENCE, V315, P972, DOI 10.1126/science.1136800
   GELADI P, 1986, ANAL CHIM ACTA, V185, P1, DOI 10.1016/0003-2670(86)80028-9
   Ginsberg HN, 2009, J LIPID RES, V50, pS162, DOI 10.1194/jlr.R800090-JLR200
   Guillou H, 2004, J LIPID RES, V45, P32, DOI 10.1194/jlr.M300339-JLR200
   Guillou H, 2010, PROG LIPID RES, V49, P186, DOI 10.1016/j.plipres.2009.12.002
   Hitosugi T, 2011, MOL CELL, V44, P864, DOI 10.1016/j.molcel.2011.10.015
   Hitosugi T, 2009, SCI SIGNAL, V2, DOI 10.1126/scisignal.2000431
   Homan EA, 2011, J AM CHEM SOC, V133, P5178, DOI 10.1021/ja111173c
   Hskuldsson A., 1988, J CHEMOMETR, V2, P211, DOI [10.1002/cem.1180020306, DOI 10.1002/CEM.1180020306]
   Huang PH, 2010, MOL BIOSYST, V6, P1227, DOI 10.1039/c001196g
   Janes KA, 2004, J COMPUT BIOL, V11, P544, DOI 10.1089/cmb.2004.11.544
   Ji C, 2006, J HEPATOL, V45, P321, DOI 10.1016/j.jhep.2006.06.004
   Kashyap Sangeeta R, 2007, Diab Vasc Dis Res, V4, P13, DOI 10.3132/dvdr.2007.001
   Koltun DO, 2009, BIOORG MED CHEM LETT, V19, P4070, DOI 10.1016/j.bmcl.2009.06.017
   Kumar N, 2007, PLOS COMPUT BIOL, V3, P35, DOI 10.1371/journal.pcbi.0030004
   Liu XQ, 2011, ADV NUTR, V2, P15, DOI 10.3945/an.110.000125
   Manevich Y, 2007, J LIPID RES, V48, P2306, DOI 10.1194/jlr.M700299-JLR200
   Martin SE, 2000, ANAL CHEM, V72, P4266, DOI 10.1021/ac000497v
   Naegle KM, 2010, MOL CELL PROTEOMICS, V9, P2558, DOI 10.1074/mcp.M110.001206
   Nelson PRC, 1996, CHEMOMETR INTELL LAB, V35, P45, DOI 10.1016/S0169-7439(96)00007-X
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Pan MH, 2004, J CLIN INVEST, V113, P1277, DOI 10.1172/JCI200419197
   Popkin BM, 2012, NUTR REV, V70, P3, DOI 10.1111/j.1753-4887.2011.00456.x
   Qiu W, 2004, DIABETES, V53, P3057, DOI 10.2337/diabetes.53.12.3057
   Ren LG, 2011, BIOCHEMISTRY-US, V50, P2339, DOI 10.1021/bi1014453
   Rhee EP, 2011, J CLIN INVEST, V121, P1402, DOI 10.1172/JCI44442
   ROSENDAL J, 1993, BIOCHEM J, V290, P321, DOI 10.1042/bj2900321
   Rubin DB, 1996, J AM STAT ASSOC, V91, P473, DOI 10.1080/01621459.1996.10476908
   Rutter GA, 2000, CURR BIOL, V10, pR736, DOI 10.1016/S0960-9822(00)00737-5
   Schenkman JB, 2003, PHARMACOL THERAPEUT, V97, P139, DOI 10.1016/S0163-7258(02)00327-3
   Schmelzle K, 2006, DIABETES, V55, P2171, DOI 10.2337/db06-0148
   Smith CA, 2006, ANAL CHEM, V78, P779, DOI 10.1021/ac051437y
   Stefan N, 2008, DIABETOLOGIA, V51, P648, DOI 10.1007/s00125-008-0938-7
   Subramanian A, 2005, P NATL ACAD SCI USA, V102, P15545, DOI 10.1073/pnas.0506580102
   Taniguchi CM, 2006, NAT REV MOL CELL BIO, V7, P85, DOI 10.1038/nrm1837
   Taskinen JP, 2007, PROTEINS, V66, P229, DOI 10.1002/prot.21124
   Vinayavekhin N, 2011, J AM CHEM SOC, V133, P17168, DOI 10.1021/ja208199h
   Wang Q, 2009, HEPATOLOGY, V49, P1166, DOI 10.1002/hep.22774
   Wellen KE, 2009, SCIENCE, V324, P1076, DOI 10.1126/science.1164097
   WOLD S, 1987, CHEMOMETR INTELL LAB, V2, P37, DOI 10.1016/0169-7439(87)80084-9
   Wolf-Yadlin A, 2007, P NATL ACAD SCI USA, V104, P5860, DOI 10.1073/pnas.0608638104
   Wolf-Yadlin A, 2006, MOL SYST BIOL, V2, DOI 10.1038/msb4100094
   Yamazaki T, 2005, J BIOL CHEM, V280, P21506, DOI 10.1074/jbc.M412989200
   Yip SC, 2010, TRENDS BIOCHEM SCI, V35, P442, DOI 10.1016/j.tibs.2010.03.004
   Zhang KZ, 2008, NATURE, V454, P455, DOI 10.1038/nature07203
   Zhang Y, 2005, MOL CELL PROTEOMICS, V4, P1240, DOI 10.1074/mcp.M500089-MCP200
   Zinker BA, 2002, P NATL ACAD SCI USA, V99, P11357, DOI 10.1073/pnas.142298199
NR 59
TC 16
Z9 20
U1 0
U2 16
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1757-9694
EI 1757-9708
J9 INTEGR BIOL-UK
JI Integr. Biol.
PY 2013
VL 5
IS 7
BP 940
EP 963
DI 10.1039/c3ib40013a
PG 24
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 170TP
UT WOS:000320877100003
PM 23685806
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lim, S
   Quon, MJ
   Koh, KK
AF Lim, Soo
   Quon, Michael J.
   Koh, Kwang Kon
TI Modulation of adiponectin as a potential therapeutic strategy
SO ATHEROSCLEROSIS
LA English
DT Review
DE Adiponectin; Cardiovascular disease; Insulin resistance;
   Atherosclerosis; Obesity
ID HIGH-MOLECULAR-WEIGHT; CAUSES INSULIN-RESISTANCE;
   ACTIVATED-RECEPTOR-GAMMA; CORONARY-ARTERY-DISEASE; INCREASES
   PLASMA-LEVELS; ALL-CAUSE MORTALITY; ENDOTHELIAL FUNCTION; PPAR-GAMMA;
   OXIDATIVE STRESS; MYOCARDIAL-INFARCTION
AB Adiponectin is produced predominantly by adipocytes and plays an important role in metabolic and cardiovascular homeostasis through its insulin-sensitizing actions and anti-inflammatory and anti-atherogenic properties. Recently, it has been observed that lower levels of adiponectin can substantially increase the risk of developing type 2 diabetes, metabolic syndrome, atherosclerosis, and cardiovascular disease in patients who are obese. Circulating adiponectin levels are inversely related to the inflammatory process, oxidative stress, and metabolic dysregulation. Intensive lifestyle modifications and pharmacologic agents, including peroxisome proliferator-activated receptor-gamma or alpha agonists, some statins, renin-angiotensin-aldosterone system blockers, some calcium channel blockers, mineralocorticoid receptor blockers, new beta-blockers, and several natural compounds can increase adiponectin levels and suppress or prevent disease initiation or progression, respectively, in cardiovascular and metabolic disorders. Therefore, it is important for investigators to have a thorough understanding of the interventions that can modulate adiponectin. Such knowledge may lead to new therapeutic approaches for diseases such as type 2 diabetes, metabolic syndrome, cardiovascular disease, and obesity. This review focuses on recent updates regarding therapeutic interventions that might modulate adiponectin. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Lim, Soo] Seoul Natl Univ, Bundang Hosp, Coll Med, Div Endocrinol, Songnam, South Korea.
   [Quon, Michael J.] Univ Maryland, Sch Med, Dept Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA.
   [Koh, Kwang Kon] Gachon Univ, Gil Med Ctr, Inchon 405760, South Korea.
   [Koh, Kwang Kon] Gachon Cardiovasc Res Inst, Inchon, South Korea.
C3 Seoul National University (SNU); University System of Maryland;
   University of Maryland Baltimore; Gachon University; Gachon University
RP Koh, KK (corresponding author), Gachon Univ, Gil Med Ctr, Vasc Med & Atherosclerosis Unit, 1198 Kuwol Dong, Inchon 405760, South Korea.
EM kwangk@gilhospital.com
RI Quon, Michael/B-1970-2008; Lim, Soo/AAU-8107-2020
OI Quon, Michael/0000-0002-9601-9915; Lim, Soo/0000-0002-4137-1671; QUON,
   MICHAEL/0000-0002-5289-3707
FU established investigator award; Gachon University Gil Hospital
FX This study was supported in part by grants from established investigator
   award (2012), Gachon University Gil Hospital (KKK).
CR Abbenhardt C, 2013, J INTERN MED, V274, P163, DOI 10.1111/joim.12062
   Abe M, 2010, DRUG METAB PHARMACOK, V25, P274, DOI 10.2133/dmpk.25.274
   Beatty AL, 2012, ATHEROSCLEROSIS, V220, P587, DOI 10.1016/j.atherosclerosis.2011.11.038
   Benedix F, 2011, OBES SURG, V21, P616, DOI 10.1007/s11695-011-0374-5
   Bluher M, 2006, J CLIN ENDOCR METAB, V91, P2310, DOI 10.1210/jc.2005-2556
   Boden WE, 2011, NEW ENGL J MED, V365, P2255, DOI 10.1056/NEJMoa1107579
   Bosch J, 2005, CIRCULATION, V112, P1339, DOI 10.1161/CIRCULATIONAHA.105.548461
   BROWN G, 1990, NEW ENGL J MED, V323, P1289, DOI 10.1056/NEJM199011083231901
   Cambuli VM, 2008, J CLIN ENDOCR METAB, V93, P3051, DOI 10.1210/jc.2008-0476
   Cavusoglu E, 2006, EUR HEART J, V27, P2300, DOI 10.1093/eurheartj/ehl153
   Celik T, 2006, J HYPERTENS, V24, P591, DOI 10.1097/01.hjh.0000209993.26057.de
   Chamberlain LH, 2001, FEBS LETT, V507, P357, DOI 10.1016/S0014-5793(01)03007-1
   Chen H, 2003, J BIOL CHEM, V278, P45021, DOI 10.1074/jbc.M307878200
   Cheyssac C, 2006, DIABETES, V55, P1171, DOI 10.2337/diabetes.55.04.06.db05-1298
   Chinetti G, 2004, BIOCHEM BIOPH RES CO, V314, P151, DOI 10.1016/j.bbrc.2003.12.058
   Christou G A., 2013, Obesity reviews
   Civitarese AE, 2004, DIABETOLOGIA, V47, P816, DOI 10.1007/s00125-004-1359-x
   Esfandiari F, 2007, ALCOHOL CLIN EXP RES, V31, P1231, DOI 10.1111/j.1530-0277.2007.00407.x
   Esposito K, 2003, JAMA-J AM MED ASSOC, V289, P1799, DOI 10.1001/jama.289.14.1799
   Flegal KM, 2013, JAMA-J AM MED ASSOC, V309, P71, DOI 10.1001/jama.2012.113905
   Fujita K, 2008, ARTERIOSCL THROM VAS, V28, P863, DOI 10.1161/ATVBAHA.107.156687
   Funder JW, 2005, HEART FAIL REV, V10, P15, DOI 10.1007/s10741-005-2344-2
   Furuhashi M, 2003, HYPERTENSION, V42, P76, DOI 10.1161/01.HYP.0000078490.59735.6E
   Guo C, 2008, CIRCULATION, V117, P2253, DOI 10.1161/CIRCULATIONAHA.107.748640
   GURWITZ JH, 1993, ANN INTERN MED, V118, P273, DOI 10.7326/0003-4819-118-4-199302150-00005
   Hainer V, 2013, DIABETES CARE, V36, pS276, DOI 10.2337/dcS13-2023
   Hickman IJ, 2012, CURR MED CHEM, V19, P5427
   Hino K, 2011, J BIOMOL SCREEN, V16, P628, DOI 10.1177/1087057111403474
   Hirata A, 2009, CARDIOVASC RES, V84, P164, DOI 10.1093/cvr/cvp191
   Holmes RM, 2011, DIABETOLOGIA, V54, P2122, DOI 10.1007/s00125-011-2173-x
   Jee SH, 2013, DIABETES METAB J, V37, P252, DOI 10.4093/dmj.2013.37.4.252
   Joo SJ, 2012, KOREAN CIRC J, V42, P592, DOI 10.4070/kcj.2012.42.9.592
   Kadowaki T, 2006, J CLIN INVEST, V116, P1784, DOI 10.1172/JCI29126
   Kharroubi I, 2003, BIOCHEM BIOPH RES CO, V312, P1118, DOI 10.1016/j.bbrc.2003.11.042
   Kim CH, 2006, AM J PHYSIOL-ENDOC M, V291, pE298, DOI 10.1152/ajpendo.00319.2005
   Kizer JR, 2012, CIRCULATION, V126, P2951, DOI 10.1161/CIRCULATIONAHA.112.135202
   Kobashi C, 2005, CIRC RES, V97, P1245, DOI 10.1161/01.RES.0000194328.57164.36
   Koh KK, 2005, J AM COLL CARDIOL, V45, P1649, DOI 10.1016/j.jacc.2005.02.052
   Koh KK, 2004, CIRCULATION, V110, P3687, DOI 10.1161/01.CIR.0000143085.86697.13
   Koh KK, 2007, DIABETES CARE, V30, P1605, DOI 10.2337/dc06-2267
   Koh KK, 2010, J AM COLL CARDIOL, V55, P1209, DOI 10.1016/j.jacc.2009.10.053
   Koh KK, 2009, ATHEROSCLEROSIS, V204, P483, DOI 10.1016/j.atherosclerosis.2008.09.021
   Koh KK, 2010, INT J CARDIOL, V140, P73, DOI 10.1016/j.ijcard.2008.11.017
   Kumada M, 2004, CIRCULATION, V109, P2046, DOI 10.1161/01.CIR.0000127953.98131.ED
   Kurogi K, 2013, J CARDIOL, V62, P87, DOI 10.1016/j.jjcc.2013.03.008
   Li SS, 2009, JAMA-J AM MED ASSOC, V302, P179, DOI 10.1001/jama.2009.976
   Lim S, 2008, J CLIN ENDOCR METAB, V93, P2263, DOI 10.1210/jc.2007-2028
   Lim S, 2014, ANTIOXID REDOX SIGN, V20, P1286, DOI 10.1089/ars.2013.5531
   Lim S, 2011, CARDIOVASC RES, V90, P383, DOI 10.1093/cvr/cvr009
   Lim S, 2010, OBESITY, V18, P826, DOI 10.1038/oby.2009.232
   Liu K, 2010, BIOCHIMIE, V92, P789, DOI 10.1016/j.biochi.2010.02.024
   Liu Y, 2007, J CLIN ENDOCR METAB, V92, P4313, DOI 10.1210/jc.2007-0890
   Manson JE, 2002, NEW ENGL J MED, V347, P716, DOI 10.1056/NEJMoa021067
   Mao XM, 2006, NAT CELL BIOL, V8, P516, DOI 10.1038/ncb1404
   Matsuzawa Yuji, 2005, Curr Atheroscler Rep, V7, P58, DOI 10.1007/s11883-005-0076-3
   Miller RA, 2011, J CLIN INVEST, V121, P2518, DOI 10.1172/JCI45942
   Motoshima H, 2004, BIOCHEM BIOPH RES CO, V315, P264, DOI 10.1016/j.bbrc.2004.01.049
   Okada-Iwabu M, 2013, NATURE, V503, P493, DOI 10.1038/nature12656
   Pajvani UB, 2003, J BIOL CHEM, V278, P9073, DOI 10.1074/jbc.M207198200
   Pischon T, 2004, JAMA-J AM MED ASSOC, V291, P1730, DOI 10.1001/jama.291.14.1730
   Plaisance EP, 2009, AM J PHYSIOL-ENDOC M, V296, pE549, DOI 10.1152/ajpendo.91004.2008
   Preiss D, 2011, JAMA-J AM MED ASSOC, V305, P2556, DOI 10.1001/jama.2011.860
   Rosenson RS, 2007, DIABETES CARE, V30, P1945, DOI 10.2337/dc07-0015
   Saito I, 2013, ATHEROSCLEROSIS, V229, P222, DOI 10.1016/j.atherosclerosis.2013.04.014
   Sattar N, 2010, LANCET, V375, P735, DOI 10.1016/S0140-6736(09)61965-6
   SCHERER PE, 1995, J BIOL CHEM, V270, P26746, DOI 10.1074/jbc.270.45.26746
   Schneider JG, 2005, DIABETES CARE, V28, P2181, DOI 10.2337/diacare.28.9.2181
   Summer SS, 2011, OBESITY, V19, P2198, DOI 10.1038/oby.2011.60
   Sun YY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0063354
   Tao L, 2010, CIRC RES, V106, P409, DOI 10.1161/CIRCRESAHA.109.211797
   Tomé-Carneiro J, 2012, AM J CARDIOL, V110, P356, DOI 10.1016/j.amjcard.2012.03.030
   Tomiyama H, 2005, AM J HYPERTENS, V18, P178, DOI 10.1016/j.amjhyper.2004.08.033
   Tsubakio-Yamamoto K, 2008, BIOCHEM BIOPH RES CO, V375, P390, DOI 10.1016/j.bbrc.2008.08.009
   Tsuchida A, 2005, DIABETES, V54, P3358, DOI 10.2337/diabetes.54.12.3358
   Tullin S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0044270
   Van Linthout S, 2010, ATHEROSCLEROSIS, V210, P438, DOI 10.1016/j.atherosclerosis.2010.01.001
   Wang ZV, 2007, MOL CELL BIOL, V27, P3716, DOI 10.1128/MCB.00931-06
   Westphal S, 2006, METABOLISM, V55, P1283, DOI 10.1016/j.metabol.2006.07.002
   Willsky GR, 2001, J INORG BIOCHEM, V85, P33, DOI 10.1016/S0162-0134(00)00226-9
   Wong WT, 2011, CELL METAB, V14, P104, DOI 10.1016/j.cmet.2011.05.009
   Wu YL, 2013, J BIOL INORG CHEM, V18, P623, DOI 10.1007/s00775-013-1007-3
   Yamauchi T, 2003, NATURE, V423, P762, DOI 10.1038/nature01705
   Yamauchi T, 2001, NAT MED, V7, P941, DOI 10.1038/90984
   Yamauchi Toshimasa, 2003, Current Drug Targets - Immune Endocrine and Metabolic Disorders, V3, P243, DOI 10.2174/1568008033340090
   Yang WS, 2001, J CLIN ENDOCR METAB, V86, P3815, DOI 10.1210/jc.86.8.3815
   Yang WS, 2002, DIABETES CARE, V25, P376, DOI 10.2337/diacare.25.2.376
   Zhou MS, 2004, AM J HYPERTENS, V17, P167, DOI 10.1016/j.amjhyper.2003.09.007
NR 87
TC 112
Z9 124
U1 2
U2 32
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD APR
PY 2014
VL 233
IS 2
BP 721
EP 728
DI 10.1016/j.atherosclerosis.2014.01.051
PG 8
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AE9OM
UT WOS:000334337200062
PM 24603219
DA 2025-06-11
ER

PT J
AU Kobori, M
   Takahashi, Y
   Takeda, H
   Takahashi, M
   Izumi, Y
   Akimoto, Y
   Sakurai, M
   Oike, H
   Nakagawa, T
   Itoh, M
   Bamba, T
   Kimura, T
AF Kobori, Masuko
   Takahashi, Yumiko
   Takeda, Hiroaki
   Takahashi, Masatomo
   Izumi, Yoshihiro
   Akimoto, Yukari
   Sakurai, Mutsumi
   Oike, Hideaki
   Nakagawa, Toshiyuki
   Itoh, Masanori
   Bamba, Takeshi
   Kimura, Toshiyuki
TI Dietary Intake of Curcumin Improves eIF2 Signaling and Reduces Lipid
   Levels in the White Adipose Tissue of Obese Mice
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; GENE-EXPRESSION; PPAR-GAMMA; ER STRESS; LIPOLYSIS;
   METABOLITES; BINDING; ADIPOGENESIS
AB White adipose tissue (eWAT) plays a crucial role in preventing metabolic syndrome. We aimed to investigate WAT distribution and gene expression and lipidomic profiles in epididymal WAT (eWAT) in diet-induced obese mice, reflecting a Western-style diet of humans to elucidate the bioactive properties of the dietary antioxidant curcumin in preventing lifestyle-related diseases. For 16 weeks, we fed C57BL/6J mice with a control diet, a high-fat, high-sucrose and high-cholesterol Western diet or Western diet supplemented with 0.1% (w/w) curcumin. Although the dietary intake of curcumin did not affect eWAT weight or plasma lipid levels, it reduced lipid peroxidation markers' levels in eWAT. Curcumin accumulated in eWAT and changed gene expressions related to eukaryotic translation initiation factor 2 (eIF2) signalling. Curcumin suppressed eIF2 alpha phosphorylation, which is induced by endoplasmic reticulum (ER) stress, macrophage accumulation and nuclear factor-kappa B (NF-kappa B) p65 and leptin expression, whereas it's anti-inflammatory effect was inadequate to decrease TNF-alpha and IFN-gamma levels. Lipidomic and gene expression analysis revealed that curcumin decreased some diacylglycerols (DAGs) and DAG-derived glycerophospholipids levels by suppressing the glycerol-3-phosphate acyltransferase 1 and adipose triglyceride lipase expression, which are associated with lipogenesis and lipolysis, respectively. Presumably, these intertwined effects contribute to metabolic syndrome prevention by dietary modification.
C1 [Kobori, Masuko; Takahashi, Yumiko; Akimoto, Yukari; Sakurai, Mutsumi; Oike, Hideaki; Kimura, Toshiyuki] Natl Agr & Food Res Org, Food Res Inst, Tsukuba, Ibaraki 3058642, Japan.
   [Takeda, Hiroaki; Takahashi, Masatomo; Izumi, Yoshihiro; Bamba, Takeshi] Kyushu Univ, Med Inst Bioregulat, Fukuoka, Fukuoka 8128582, Japan.
   [Nakagawa, Toshiyuki; Itoh, Masanori] Gifu Univ, Grad Sch Med, Dept Neurobiol, Gifu, Gifu 5011194, Japan.
C3 National Agriculture & Food Research Organization - Japan; Kyushu
   University; Gifu University
RP Kobori, M (corresponding author), Natl Agr & Food Res Org, Food Res Inst, Tsukuba, Ibaraki 3058642, Japan.
EM kobori@affrc.go.jp
RI Takeda, Hiroaki/LTF-3416-2024; Bamba, Takeshi/KOD-6144-2024; Oike,
   Hideaki/C-6457-2009
OI Izumi, Yoshihiro/0000-0003-4608-4652; Takeda,
   Hiroaki/0000-0002-9299-4748; Oike, Hideaki/0000-0002-6139-5726; Bamba,
   Takeshi/0000-0002-7442-2738; Nakagawa, Toshiyuki/0000-0001-8415-4119
FU Ministry of Agriculture, Forestry and Fisheries (MAFF); Research Project
   on Development of Agricultural Products and Foods with Health-Promoting
   Benefits, National Agriculture and Food Research Organization (NARO);
   Ministry of Education, Culture, Sports, Science and Technology, Japan
   [15K00867]; Uragami Foundation; Advanced low carbon technology research
   and development program (ALCA) of the Japan Science and Technolocy
   Agency (JST); Japan Agency for Medical Research and Development (AMED);
   Creation of Innovative Technology for Medical Applications Based on the
   Global Analyses and Regulation of Disease-Related Metabolites Project of
   the AMED [JPMJCR1395]; Grants-in-Aid for Scientific Research [15K00867]
   Funding Source: KAKEN
FX This work was financially supported in part by a grant from a Ministry
   of Agriculture, Forestry and Fisheries (MAFF) research project for the
   special scheme to deploy highly advanced technology for agriculture,
   forestry, and fisheries (to M.K. and T.B.), a grant from the Research
   Project on Development of Agricultural Products and Foods with
   Health-Promoting Benefits, National Agriculture and Food Research
   Organization (NARO) (to M.K.), Ministry of Education, Culture, Sports,
   Science and Technology, Japan (15K00867 to M.K.), the Uragami Foundation
   (to M.K.), a grant from the Advanced low carbon technology research and
   development program (ALCA) of the Japan Science and Technolocy Agency
   (JST) (to Y.I. and T.B.), a grant from the Studies on Specific
   Activities and Functions of Lipid Molecules to Develop Innovative
   Medical Technologies Project of the Japan Agency for Medical Research
   and Development (AMED) (to Y.I. and T.B.), and a grant from the Creation
   of Innovative Technology for Medical Applications Based on the Global
   Analyses and Regulation of Disease-Related Metabolites Project
   (JPMJCR1395) of the AMED (to T.B.). We thank Dr. Hiroshi Ono and Ms.
   Tomoko Sato for performing the UHPLC-ESI-Q-Orbitrap-MS analysis at
   Advanced Analysis Center, NARO. We thank Dr. Ohnishi-Kameyama (Food
   Research Institute, NARO), for valuable advice. We thank Enago (Crimson
   Interactive Japan, Tokyo, Japan) for the English language review.
CR Bamba T, 2012, J CHROMATOGR A, V1250, P212, DOI 10.1016/j.chroma.2012.05.068
   Bisson J, 2016, J MED CHEM, V59, P1671, DOI 10.1021/acs.jmedchem.5b01009
   BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911
   Brestoff JR, 2015, CELL, V161, P146, DOI 10.1016/j.cell.2015.02.022
   Cassidy A, 2016, AM J CLIN NUTR, V104, P587, DOI 10.3945/ajcn.116.133132
   Chen HC, 2002, J CLIN INVEST, V109, P1049, DOI 10.1172/JCI0214672
   Conseil G, 1998, P NATL ACAD SCI USA, V95, P9831, DOI 10.1073/pnas.95.17.9831
   Deng JN, 2012, J BIOL CHEM, V287, P6240, DOI 10.1074/jbc.M111.299115
   Deng T, 2013, CELL METAB, V17, P411, DOI 10.1016/j.cmet.2013.02.009
   Edgar R, 2002, NUCLEIC ACIDS RES, V30, P207, DOI 10.1093/nar/30.1.207
   Ejaz A, 2009, J NUTR, V139, P919, DOI 10.3945/jn.108.100966
   Fabbrini E, 2015, J CLIN INVEST, V125, P787, DOI 10.1172/JCI78425
   Fuchs CD, 2012, HEPATOLOGY, V56, P270, DOI 10.1002/hep.25601
   Gaidhu MP, 2010, AM J PHYSIOL-CELL PH, V298, pC961, DOI 10.1152/ajpcell.00547.2009
   Garcea G, 2004, BRIT J CANCER, V90, P1011, DOI 10.1038/sj.bjc.6601623
   Goetz ME, 2016, J NUTR, V146, P2233, DOI 10.3945/jn.116.230185
   Han J, 2013, DIABETOLOGIA, V56, P911, DOI 10.1007/s00125-012-2809-5
   Heger M, 2014, PHARMACOL REV, V66, P222, DOI 10.1124/pr.110.004044
   Horrillo R, 2010, J IMMUNOL, V184, P3978, DOI 10.4049/jimmunol.0901355
   Jantan I, 2015, FRONT PLANT SCI, V6, DOI 10.3389/fpls.2015.00655
   Kawasaki N, 2012, SCI REP-UK, V2, DOI 10.1038/srep00799
   Khan F, 2016, NUTRIENTS, V8, DOI 10.3390/nu8090529
   Kobori M, 2016, MOL NUTR FOOD RES, V60, P300, DOI 10.1002/mnfr.201500595
   Kobori M, 2011, MOL NUTR FOOD RES, V55, P530, DOI 10.1002/mnfr.201000392
   Kunnumakkara AB, 2017, BRIT J PHARMACOL, V174, P1325, DOI 10.1111/bph.13621
   Kwon Y, 2014, NUTR RES PRACT, V8, P589, DOI 10.4162/nrp.2014.8.5.589
   Lee JH, 2013, J APPL MATH, DOI 10.1155/2013/101670
   Lee SJ, 2010, CARDIOVASC RES, V88, P352, DOI 10.1093/cvr/cvq194
   Lefterova MI, 2008, GENE DEV, V22, P2941, DOI 10.1101/gad.1709008
   Marczylo TH, 2009, J AGR FOOD CHEM, V57, P797, DOI 10.1021/jf803038f
   Mauvoisin D, 2011, BIOCHIMIE, V93, P78, DOI 10.1016/j.biochi.2010.08.001
   Michael J Morgan, 2011, Cell Research, V21, P103
   Nelson KM, 2017, J MED CHEM, V60, P1620, DOI 10.1021/acs.jmedchem.6b00975
   Nishimuro H, 2015, NUTRIENTS, V7, P2345, DOI 10.3390/nu7042345
   Ouchi N, 2011, NAT REV IMMUNOL, V11, P85, DOI 10.1038/nri2921
   Pan MH, 1999, DRUG METAB DISPOS, V27, P486
   Pietiläinen KH, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1000623
   Polvani S, 2012, PPAR RES, V2012, DOI 10.1155/2012/641087
   Prieto-Hontoria PL, 2011, MOL NUTR FOOD RES, V55, P1059, DOI 10.1002/mnfr.201000534
   Rodríguez-Monforte M, 2017, EUR J NUTR, V56, P925, DOI 10.1007/s00394-016-1305-y
   Ryu H, 2003, J NEUROSCI, V23, P3597
   Saponaro C, 2015, NUTRIENTS, V7, P9453, DOI 10.3390/nu7115475
   Jiménez-Osorio AS, 2016, BIOFACTORS, V42, P561, DOI 10.1002/biof.1302
   Storey JD, 2003, P NATL ACAD SCI USA, V100, P9440, DOI 10.1073/pnas.1530509100
   Takeuchi K, 2009, AM J PHYSIOL-ENDOC M, V296, pE1195, DOI 10.1152/ajpendo.90958.2008
   Tresserra-Rimbau A, 2016, J NUTR, V146, P767, DOI 10.3945/jn.115.223610
   Tripathi YB, 2012, FRONT IMMUNOL, V3, DOI 10.3389/fimmu.2012.00240
   Uchikata T, 2012, J CHROMATOGR A, V1250, P69, DOI 10.1016/j.chroma.2012.06.031
   Vareed SK, 2008, CANCER EPIDEM BIOMAR, V17, P1411, DOI 10.1158/1055-9965.EPI-07-2693
   Wang LL, 2016, J LIPID RES, V57, P1243, DOI 10.1194/jlr.M067397
   Wendel AA, 2009, BBA-MOL CELL BIOL L, V1791, P501, DOI 10.1016/j.bbalip.2008.10.010
   Yahagi N, 2002, J BIOL CHEM, V277, P19353, DOI 10.1074/jbc.M201584200
   Ye JP, 2008, BIOCHEM BIOPH RES CO, V374, P405, DOI 10.1016/j.bbrc.2008.07.068
   Yen CLE, 2008, J LIPID RES, V49, P2283, DOI 10.1194/jlr.R800018-JLR200
   Zamora-Ros R, 2014, J NUTR, V144, P335, DOI 10.3945/jn.113.184945
NR 55
TC 28
Z9 29
U1 2
U2 11
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 13
PY 2018
VL 8
AR 9081
DI 10.1038/s41598-018-27105-w
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GJ2CT
UT WOS:000435077300024
PM 29899429
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Du, X
   Liu, ZY
   Tao, XX
   Mei, YL
   Zhou, DQ
   Cheng, K
   Gao, SL
   Shi, HY
   Song, C
   Zhang, XM
AF Du, Xin
   Liu, Zi-yu
   Tao, Xing-xing
   Mei, Yong-liang
   Zhou, Da-qian
   Cheng, Kang
   Gao, Si-long
   Shi, Hou-yin
   Song, Chao
   Zhang, Xiao-min
TI Research Progress on the Pathogenesis of Knee Osteoarthritis
SO ORTHOPAEDIC SURGERY
LA English
DT Review
DE Bone Metabolism; Cytokines; Inflammation; Knee Osteoarthritis; Long
   Non-Coding RNA
ID NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; SYMPTOMATIC KNEE; EXPRESSION;
   INFLAMMATION; OBESITY; ASSOCIATION; PREVALENCE; BIOMARKERS; COLLAGEN
AB Knee osteoarthritis (KOA) is a chronic joint bone disease characterized by inflammatory destruction and hyperplasia of bone. Its main clinical symptoms are joint mobility difficulties and pain, severe cases can lead to limb paralysis, which poses major pressure to the quality of life and mental health of patients, but also brings serious economic burden to society. The occurrence and development of KOA is influenced by many factors, including systemic factors and local factors. The joint biomechanical changes caused by aging, trauma and obesity, abnormal bone metabolism caused by metabolic syndrome, the effects of cytokines and related enzymes, genetic and biochemical abnormalities caused by plasma adiponectin, etc. all directly or indirectly lead to the occurrence of KOA. However, there is little literature that systematically and comprehensively integrates macro- and microscopic KOA pathogenesis. Therefore, it is necessary to comprehensively and systematically summarize the pathogenesis of KOA in order to provide a better theoretical basis for clinical treatment.
C1 [Du, Xin; Liu, Zi-yu; Tao, Xing-xing] Southwest Med Univ, Affiliated Hosp Tradit Chinese Med, Ctr Phenom Tradit Chinese Med, Luzhou, Peoples R China.
   [Mei, Yong-liang; Zhou, Da-qian; Cheng, Kang; Gao, Si-long; Song, Chao; Zhang, Xiao-min] Southwest Med Univ, Affiliated Hosp Tradit Chinese Med, Dept Orthopaed & Traumatol Trauma & Bone Setting, Luzhou, Sichuan, Peoples R China.
   [Shi, Hou-yin] Southwest Med Univ, Affiliated Hosp Tradit Chinese Med, Med Dept, Luzhou, Peoples R China.
C3 Southwest Medical University; Southwest Medical University; Southwest
   Medical University
RP Zhang, XM (corresponding author), Southwest Med Univ, Affiliated Hosp Tradit Chinese Med, Dept Orthopaed & Traumatol Trauma & Bone Setting, Luzhou, Sichuan, Peoples R China.
EM 243087898@qq.com
RI Song, Chao/KVY-3360-2024; Zhang, Xiaomin/O-5144-2015
OI Song, Chao/0000-0003-0611-4298; Du, Xin/0000-0003-2288-5770
FU Key R amp; D Projects of Sichuan Science and Technology Department
   [2022YFS0609]; Luzhou Science and Technology Project [2022-SYF-88]
FX Acknowledgement This work was supported by Key R & D Projects of Sichuan
   Science and Technology Department (Grant number: 2022YFS0609) and Luzhou
   Science and Technology Project (Grant number: 2022-SYF-88).
CR Abramoff B, 2020, MED CLIN N AM, V104, P293, DOI 10.1016/j.mcna.2019.10.007
   Akdis CA, 2011, J ALLERGY CLIN IMMUN, V127, P18, DOI 10.1016/j.jaci.2010.11.030
   Anderson AS, 2010, BEST PRACT RES CL RH, V24, P15, DOI 10.1016/j.berh.2009.08.006
   Ashmeik W, 2020, SKELETAL RADIOL, V49, P1359, DOI 10.1007/s00256-020-03409-9
   Baran P, 2018, J BIOL CHEM, V293, P6762, DOI 10.1074/jbc.RA117.001163
   Batushansky A, 2022, OSTEOARTHR CARTILAGE, V30, P501, DOI 10.1016/j.joca.2021.06.013
   Berenbaum F, 2018, NAT REV RHEUMATOL, V14, P674, DOI 10.1038/s41584-018-0073-x
   Berenbaum F, 2012, POSTGRAD MED J, V88, P240, DOI 10.1136/pgmj.2010.146399rep
   Bodmer JL, 2002, TRENDS BIOCHEM SCI, V27, P19, DOI 10.1016/S0968-0004(01)01995-8
   Bolduc JA, 2019, FREE RADICAL BIO MED, V132, P73, DOI 10.1016/j.freeradbiomed.2018.08.038
   Booij MJ, 2020, KNEE, V27, P198, DOI 10.1016/j.knee.2019.10.006
   Calvet J, 2016, SCAND J RHEUMATOL, V45, P41, DOI 10.3109/03009742.2015.1054875
   Cannata F, 2020, DIABETES-METAB RES, V36, DOI 10.1002/dmrr.3254
   Chen LA, 2010, J BONE MINER RES, V25, P2447, DOI 10.1002/jbmr.133
   Chen YX, 2019, MED SCI MONITOR, V25, P2058, DOI 10.12659/MSM.915555
   Chen Z, 2016, FRONT BIOSCI-LANDMRK, V21, P1222, DOI 10.2741/4452
   Ching K, 2021, NAT REV RHEUMATOL, V17, P533, DOI 10.1038/s41584-021-00650-x
   Chu LY, 2020, J BONE MINER RES, V35, P505, DOI 10.1002/jbmr.3909
   Chwastek J, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms231911817
   Clockaerts S, 2010, OSTEOARTHR CARTILAGE, V18, P876, DOI 10.1016/j.joca.2010.03.014
   Dai Q-p., 2003, SCIENCE, V300, P1730
   Duclos M, 2016, ANN PHYS REHABIL MED, V59, P157, DOI 10.1016/j.rehab.2016.04.002
   Efendi R., 2021, CENTRAL PERIPHERAL O
   Silva MAFS, 2020, PEDIATR ENDOCR REV P, V17, P308, DOI 10.17458/per.vol17.2020.sdl.childhoodobesitybonemetabolism
   Fan ZY, 2006, RHEUMATOL INT, V26, P900, DOI 10.1007/s00296-006-0114-7
   Felson DT, 2016, OSTEOARTHR CARTILAGE, V24, P458, DOI 10.1016/j.joca.2015.09.013
   Felson DT, 2004, RADIOL CLIN N AM, V42, P1, DOI 10.1016/S0033-8389(03)00161-1
   Fields JK, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.01412
   Fu CL, 2022, BIOMED PHARMACOTHER, V154, DOI 10.1016/j.biopha.2022.113551
   Fu CL, 2022, EXP THER MED, V24, DOI 10.3892/etm.2022.11459
   Gaballah HH, 2019, MOL BIOL REP, V46, P657, DOI 10.1007/s11033-018-4521-0
   Hana S, 2018, CURR RHEUMATOL REV, V14, P181, DOI 10.2174/1573397113666170425150133
   He CP, 2021, BONE JOINT RES, V10, P122, DOI 10.1302/2046-3758.102.BJR-2020-0228.R1
   Hu PF, 2019, PEERJ, V7, DOI 10.7717/peerj.7024
   Hu QC, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22041742
   Hunter DJ, 2019, LANCET, V393, P1745, DOI 10.1016/S0140-6736(19)30417-9
   Jang S, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22052619
   Jarecki J, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19063530
   Jenei-Lanzl Z, 2019, CELL SIGNAL, V53, P212, DOI 10.1016/j.cellsig.2018.10.005
   Jiang MQ, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/7385160
   Kanehisa M, 2023, NUCLEIC ACIDS RES, V51, pD587, DOI 10.1093/nar/gkac963
   Kim N, 2019, GAIT POSTURE, V73, P209, DOI 10.1016/j.gaitpost.2019.07.307
   Koyama T, 2021, BMC MUSCULOSKEL DIS, V22, DOI 10.1186/s12891-020-03888-w
   Krishnasamy P, 2018, RHEUMATOLOGY, V57, P22, DOI 10.1093/rheumatology/kex515
   Kulkarni K, 2016, MATURITAS, V89, P22, DOI 10.1016/j.maturitas.2016.04.006
   Kulkarni P, 2021, ADV CLIN CHEM, V100, P37, DOI 10.1016/bs.acc.2020.04.002
   Lee BJ, 2019, J REHABIL MED, V51, P464, DOI 10.2340/16501977-2561
   Liu SY, 2022, MOL MED REP, V25, DOI 10.3892/mmr.2022.12615
   Liu XY, 2020, J CLIN LAB ANAL, V34, DOI 10.1002/jcla.23423
   Lythgo N., 2018, IFMBE P, P167
   [Anonymous], 2016, Nat Rev Dis Primers, V2, P16073, DOI [10.1038/nrdp.2016.72, 10.1038/nrdp.2016.73]
   Matejova JP, 2021, CARTILAGE, V13, p1421S, DOI 10.1177/1947603520946385
   Molnar V, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22179208
   Monibi F, 2016, J KNEE SURG, V29, P242, DOI 10.1055/s-0035-1549022
   Murphy L, 2008, ARTHRIT RHEUM-ARTHR, V59, P1207, DOI 10.1002/art.24021
   Nees TA, 2019, J CLIN MED, V8, DOI 10.3390/jcm8091343
   [Новаков Виталий Борисович Novakov Vitaly B.], 2021, [Гений ортопедии, Orthopaedic Genius, Genii ortopedii], V27, P112, DOI 10.18019/1028-4427-2021-27-1-112-120
   Onkarappa RS, 2020, INDIAN J ORTHOP, V54, P20, DOI 10.1007/s43465-020-00145-z
   Patsika G, 2014, J GERIATR PHYS THER, V37, P17, DOI 10.1519/JPT.0b013e31828fccc1
   Preece SJ, 2021, KNEE, V33, P216, DOI 10.1016/j.knee.2021.10.006
   Rose-John S, 2018, CSH PERSPECT BIOL, V10, DOI 10.1101/cshperspect.a028415
   Scanzello CR, 2017, J ORTHOP RES, V35, P735, DOI 10.1002/jor.23471
   Smith PN, 2003, ARCH PHYS MED REHAB, V84, P1895, DOI 10.1016/S0003-9993(03)00281-8
   Thomas S, 2018, RHEUMATOLOGY, V57, P61, DOI 10.1093/rheumatology/key011
   Tiyasatkulkovit W, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-48797-8
   Van Beeck A, 2013, KNEE, V20, P226, DOI 10.1016/j.knee.2013.01.005
   Veronese N, 2019, SEMIN ARTHRITIS RHEU, V49, P9, DOI 10.1016/j.semarthrit.2019.01.005
   Wang JB, 2019, ONCOL REP, V41, P1007, DOI 10.3892/or.2018.6866
   Wang TT, 2018, CYTOKINE GROWTH F R, V44, P38, DOI 10.1016/j.cytogfr.2018.10.002
   Wang X, 2011, INT J MOL MED, V27, P583, DOI 10.3892/ijmm.2011.611
   Watt FE, 2016, ARTHRITIS RHEUMATOL, V68, P2129, DOI 10.1002/art.39677
   Westacott CI, 2000, OSTEOARTHR CARTILAGE, V8, P213, DOI 10.1053/joca.1999.0292
   Willinger ML, 2021, CURR PAIN HEADACHE R, V25, DOI 10.1007/s11916-021-00956-1
   Xue EX, 2017, ONCOTARGET, V8, P41988, DOI 10.18632/oncotarget.16716
   Xue J, 2013, MOL MED REP, V8, P1755, DOI 10.3892/mmr.2013.1729
   Zhang YQ, 2004, ARTHRITIS RHEUM, V50, P1187, DOI 10.1002/art.20127
   Zhao XY, 2015, OSTEOARTHR CARTILAGE, V23, P1405, DOI 10.1016/j.joca.2015.04.002
   Zhao Y, 2018, INT ORTHOP, V42, P2865, DOI 10.1007/s00264-018-4093-6
   Zhong HM, 2013, INT IMMUNOPHARMACOL, V17, P329, DOI 10.1016/j.intimp.2013.06.027
NR 79
TC 54
Z9 61
U1 20
U2 58
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1757-7853
EI 1757-7861
J9 ORTHOP SURG
JI Orthop. Surg.
PD SEP
PY 2023
VL 15
IS 9
BP 2213
EP 2224
DI 10.1111/os.13809
EA JUL 2023
PG 12
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA R0JS5
UT WOS:001024266400001
PM 37435789
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Sabry, K
   Jamshidi, Z
   Emami, SA
   Sahebkar, A
   Akaberi, M
AF Sabry, Kamyar
   Jamshidi, Zahra
   Emami, Seyed Ahmad
   Sahebkar, Amirhossein
   Akaberi, Maryam
TI Potential therapeutic effects of baicalin and baicalein
SO AVICENNA JOURNAL OF PHYTOMEDICINE
LA English
DT Review
DE Hepatoprotective; Metabolic syndrome; Neuroprotective
ID MIGRATION INHIBITORY FACTOR; COLLAGEN-INDUCED ARTHRITIS; ACTIVATED
   PROTEIN-KINASE; NF-KAPPA-B; IN-VITRO; ADIPOCYTE DIFFERENTIATION;
   ISCHEMIA/REPERFUSION INJURY; INTRACEREBRAL HEMORRHAGE;
   LIQUID-CHROMATOGRAPHY; OXIDATIVE STRESS
AB Objective: Baicalin and baicalein are natural flavonoids reported for the first time from Scutellaria baicalensis Georgi. Recently, attention has been paid to these valuable flavonoids due to their promising effects. This paper aims to have a comprehensive review of their pharmacological effects.Materials and Methods: An extensive search through scientific databases including Scopus, PubMed, and ISI Web of Science was established.Results: According to literature, these compounds have been mainly effective in the treatment of neurological and neurodegenerative diseases, hepatic and cardiovascular disorders, metabolic syndrome, and cancers through anti-inflammatory and antioxidant pathways. Induction of apoptosis and autophagy, and inhibition of migration and metastasis are the main mechanisms for their cytotoxic and antitumor activities. Decreasing inflammation, reducing oxidative stress, regulating the metabolism of lipids, and decreasing fibrosis, apoptosis, and steatosis are their main hepatoprotective mechanisms. Inhibiting the development of cardiac fibrosis and reducing inflammation, oxidative stress, and apoptosis are also the mechanisms suggested for cardioprotective activities. Decreasing the accumulation of inflammatory mediators and improving cognitive function and depressive-like behaviours are the main mechanisms for neurological and neurodegenerative activities.Conclusion: The findings suggest the therapeutic potential of baicalin and baicalein. However, complementary research in different in vitro and in vivo models to investigate their mechanisms of action as well as clinical trials to evaluate their efficacy and safety are suggested.
C1 [Sabry, Kamyar; Akaberi, Maryam] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacognosy, Mashhad, Iran.
   [Jamshidi, Zahra] Mashhad Univ Med Sci, Sch Pharm, Dept Med Chem, Mashhad, Iran.
   [Emami, Seyed Ahmad] Mashhad Univ Med Sci, Sch Pharm, Dept Tradit Pharm, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Dept Biotechnol, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences
RP Akaberi, M (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacognosy, Mashhad, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Biotechnol, Mashhad, Iran.
EM amir_saheb2000@yahoo.com; akaberim@mums.ac.ir
RI Akaberi, Maryam/AAS-9054-2020; Sahebkar, Amirhossein/B-5124-2018; Emami,
   Seyed Ahmad/IZE-9039-2023; jamshidi, zahra/HGE-8146-2022
FU Mashhad University of Medical Sciences
FX The authors would like to thank Mashhad University of Medical Sciences
   (MUMS) for their help and support.
CR Abraham NG, 2008, PHARMACOL REV, V60, P79, DOI 10.1124/pr.107.07104
   Akao T, 2000, J PHARM PHARMACOL, V52, P1563, DOI 10.1211/0022357001777621
   Akao T, 2013, BIOL PHARM BULL, V36, P748, DOI 10.1248/bpb.b12-00850
   Alatab S, 2020, LANCET GASTROENTEROL, V5, P17, DOI 10.1016/S2468-1253(19)30333-4
   Ali T, 2012, WORLD J GASTROENTERO, V18, P197, DOI 10.3748/wjg.v18.i3.197
   Alvarez AMR, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4227-6
   Aryal P, 2014, FEBS J, V281, P4644, DOI 10.1111/febs.12969
   Asrani SK, 2019, J HEPATOL, V70, P151, DOI 10.1016/j.jhep.2018.09.014
   Bai JN, 2019, PHYTOMEDICINE, V63, DOI 10.1016/j.phymed.2019.153035
   Barnett JM, 2007, INVEST OPHTH VIS SCI, V48, P907, DOI 10.1167/iovs.06-0082
   Bullock J, 2018, MED PRIN PRACT, V27, P501, DOI 10.1159/000493390
   Cha MH, 2006, J MED FOOD, V9, P145, DOI 10.1089/jmf.2006.9.145
   Chen C, 2015, METAB BRAIN DIS, V30, P537, DOI 10.1007/s11011-014-9601-9
   Chen KL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0072927
   Chen M, 2022, FRONT NEUROL, V12, DOI 10.3389/fneur.2021.646817
   Chen M, 2021, BIOCHEM RES INT, V2021, DOI 10.1155/2021/2319412
   Chen X, 2022, INFLAMMATION, V45, P590, DOI 10.1007/s10753-021-01569-x
   Chen Y, 2019, CURR MOL MED, V19, P376, DOI 10.2174/1566524019666190405095301
   Dai CH, 2019, EXP MOL PATHOL, V106, P123, DOI 10.1016/j.yexmp.2019.01.002
   Dai SX, 2012, PHYTOTHER RES, V26, P498, DOI 10.1002/ptr.3581
   de Chambrun GP, 2016, EXPERT REV GASTROENT, V10, P915, DOI 10.1586/17474124.2016.1174064
   Dibaise John K, 2013, Expert Rev Gastroenterol Hepatol, V7, P439, DOI 10.1586/17474124.2013.811061
   Ding LLQ, 2019, BIOMED PHARMACOTHER, V111, P325, DOI 10.1016/j.biopha.2018.12.086
   Fan D, 2012, FIBROGENESIS TISSUE, V5, DOI 10.1186/1755-1536-5-15
   Fan R, 2022, EVID-BASED COMPL ALT, V2022, DOI 10.1155/2022/2112359
   Fisher FM, 2012, GENE DEV, V26, P271, DOI 10.1101/gad.177857.111
   Fu HJ, 2018, NAT NEUROSCI, V21, P1350, DOI 10.1038/s41593-018-0221-2
   Fu Y, 2014, INT J ENDOCRINOL, V2014, DOI 10.1155/2014/846742
   Fukuda D, 2021, INFLAMM REGEN, V41, DOI 10.1186/s41232-021-00160-z
   Furman D, 2019, NAT MED, V25, P1822, DOI 10.1038/s41591-019-0675-0
   Gao C, 2018, MOL NEUROBIOL, V55, P9334, DOI 10.1007/s12035-018-1042-8
   Gao W, 2022, NUTRIENTS, V14, DOI 10.3390/nu14030541
   Gao XJ, 2017, ONCOTARGET, V8, P19894, DOI 10.18632/oncotarget.15193
   Gaziano TA, 2005, CIRCULATION, V112, P3547, DOI 10.1161/CIRCULATIONAHA.105.591792
   Geis C, 2019, J CLIN INVEST, V129, P926, DOI 10.1172/JCI125178
   Gheorghe Andreea, 2015, Rom J Ophthalmol, V59, P74
   Gibbons RV, 2002, BMJ-BRIT MED J, V324, P1563, DOI 10.1136/bmj.324.7353.1563
   Gordon-Weeks AN, 2015, CYTOKINE GROWTH F R, V26, P451, DOI 10.1016/j.cytogfr.2015.03.002
   Gossard AA, 2014, MED CLIN N AM, V98, P73, DOI 10.1016/j.mcna.2013.09.002
   Guo ZX, 2015, MOL CELL BIOCHEM, V406, P111, DOI 10.1007/s11010-015-2429-8
   Hajjar DP, 2013, AM J PATHOL, V182, P1474, DOI 10.1016/j.ajpath.2013.01.010
   Hajjeh RA, 2004, J CLIN MICROBIOL, V42, P1519, DOI 10.1128/JCM.42.4.1519-1527.2004
   Hang YX, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0797-2
   Hartnett ME, 2013, J AAPOS, V17, P229, DOI 10.1016/j.jaapos.2012.12.155
   He XW, 2016, BIOMED PHARMACOTHER, V83, P257, DOI 10.1016/j.biopha.2016.06.046
   Hellström A, 2013, LANCET, V382, P1445, DOI 10.1016/S0140-6736(13)60178-6
   Hirai T, 2019, BIOMED PHARMACOTHER, V109, P503, DOI 10.1016/j.biopha.2018.10.154
   Huang H, 2017, TOXICOL APPL PHARM, V323, P36, DOI 10.1016/j.taap.2017.03.016
   Huang H, 2012, IMMUNOPHARM IMMUNOT, V34, P89, DOI 10.3109/08923973.2011.580756
   Huang T, 2019, EUR J DRUG METAB PH, V44, P159, DOI 10.1007/s13318-018-0509-3
   Huang Y, 2004, BIOCHEM PHARMACOL, V67, P787, DOI 10.1016/j.bcp.2003.10.002
   Ibrahim A, 2022, J DRUG DELIV SCI TEC, V70, DOI 10.1016/j.jddst.2022.103269
   Jia ZX, 2021, BEHAV BRAIN RES, V414, DOI 10.1016/j.bbr.2021.113463
   Jo H, 2015, BMB REP, V48, P271, DOI 10.5483/BMBRep.2015.48.5.131
   Johari J, 2012, INT J MOL SCI, V13, P16785, DOI 10.3390/ijms131216785
   Junior, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms221910604
   Kahn BB, 2005, CELL METAB, V1, P15, DOI 10.1016/j.cmet.2004.12.003
   Kesika P, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/1531567
   Kim SJ, 2012, TOXICOL APPL PHARM, V258, P43, DOI 10.1016/j.taap.2011.10.005
   Kong F, 2014, EXP THER MED, V7, P254, DOI 10.3892/etm.2013.1369
   Kwak HJ, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0176432
   Lee B, 2013, KOREAN J PHYSIOL PHA, V17, P393, DOI 10.4196/kjpp.2013.17.5.393
   Lee H, 2009, PHYTOTHER RES, V23, P1615, DOI 10.1002/ptr.2937
   Li HL, 2013, MOL MED REP, V7, P266, DOI 10.3892/mmr.2012.1123
   Li K, 2018, CHEM CENT J, V12, DOI 10.1186/s13065-018-0445-y
   Li KW, 2021, REV BRAS FARMACOGN, V31, P408, DOI 10.1007/s43450-021-00182-1
   Li L, 2022, Microbiol Spectr, V10
   Li LJ, 2021, CTS-CLIN TRANSL SCI, V14, P2017, DOI 10.1111/cts.13063
   Li M, 2014, J ETHNOPHARMACOL, V156, P210, DOI 10.1016/j.jep.2014.08.031
   Li P, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.925349
   Li SS, 2017, EUR J PHARMACOL, V815, P118, DOI 10.1016/j.ejphar.2017.07.041
   Li YC, 2021, BMC GASTROENTEROL, V21, DOI 10.1186/s12876-021-01818-1
   Liang S, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.01466
   Lin C, 1958, Acta Physiol Sin, V22, P249
   Lin CC, 1996, AM J CHINESE MED, V24, P31, DOI 10.1142/S0192415X96000050
   Lin L, 2010, PHYTOTHER RES, V24, P429, DOI 10.1002/ptr.3003
   Lin MY, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10101506
   Liu AD, 2015, INT IMMUNOPHARMACOL, V24, P72, DOI 10.1016/j.intimp.2014.11.014
   Liu F, 2018, EXP THER MED, V16, P657, DOI 10.3892/etm.2018.6284
   Liu HB, 2021, J ENZYM INHIB MED CH, V36, P497, DOI 10.1080/14756366.2021.1873977
   Liu HT, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11050947
   Liu H, 2010, J PHYS CHEM B, V114, P12938, DOI 10.1021/jp102053x
   Liu NB, 2019, CARDIOL RES PRACT, V2019, DOI 10.1155/2019/6935147
   Lu QY, 2012, PANCREAS, V41, P571, DOI 10.1097/MPA.0b013e318232e130
   Lu Y, 2019, BIOMED PHARMACOTHER, V116, DOI 10.1016/j.biopha.2019.109054
   Luan Y, 2019, J CELL BIOCHEM, V120, P3212, DOI 10.1002/jcb.27587
   Lusis AJ, 2000, NATURE, V407, P233, DOI 10.1038/35025203
   Ma P, 2015, MOL MED REP, V12, P6377, DOI 10.3892/mmr.2015.4219
   Maher P, 2008, EXP EYE RES, V86, P366, DOI 10.1016/j.exer.2007.11.009
   Maleki S, 2022, PHYTOCHEMISTRY, V201, DOI 10.1016/j.phytochem.2022.113285
   Miao Y, 2021, DOMEST ANIM ENDOCRIN, V74, DOI 10.1016/j.domaniend.2020.106508
   Moghaddam E, 2014, SCI REP-UK, V4, DOI 10.1038/srep05452
   Mokaddas EM, 2007, J MED MICROBIOL, V56, P255, DOI 10.1099/jmm.0.46817-0
   Mollazadeh H, 2019, PHYTOMEDICINE, V53, P43, DOI 10.1016/j.phymed.2018.09.024
   Moore O.A., 2016, J NUTR MED DIET CARE, V2
   Muddapu VR, 2020, FRONT NEUROSCI-SWITZ, V14, DOI 10.3389/fnins.2020.00213
   Newman DJ, 2020, J NAT PROD, V83, P770, DOI 10.1021/acs.jnatprod.9b01285
   Ntambi JM, 2000, J NUTR, V130, p3122S, DOI 10.1093/jn/130.12.3122S
   Osborne NN, 2004, PROG RETIN EYE RES, V23, P91, DOI 10.1016/j.preteyeres.2003.12.001
   OuYang L.Q., 2012, J Neurol Neurosurg Psychiatry, V39, P16
   Palierse E, 2021, MAT SCI ENG C-MATER, V118, DOI 10.1016/j.msec.2020.111537
   Pang H, 2022, J BONE ONCOL, V33, DOI 10.1016/j.jbo.2022.100415
   Peng LY, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-40684-6
   Pfaller MA, 2010, CRIT REV MICROBIOL, V36, P1, DOI 10.3109/10408410903241444
   Tuan PA, 2018, SAUDI J BIOL SCI, V25, P1639, DOI 10.1016/j.sjbs.2016.08.011
   Pollicino T, 2018, INFLAMM RES, V67, P89, DOI 10.1007/s00011-017-1099-2
   Prabhu SD, 2016, CIRC RES, V119, P91, DOI 10.1161/CIRCRESAHA.116.303577
   Pu P, 2012, MOL CELL ENDOCRINOL, V362, P128, DOI 10.1016/j.mce.2012.06.002
   Qiao D, 2022, PHYTOMEDICINE, V100, DOI 10.1016/j.phymed.2022.154046
   Rackimuthu Sudhan, 2021, Innov Pharm, V12, DOI 10.24926/iip.v12i4.4328
   Rahimi VB, 2021, PHYTOTHER RES, V35, P3558, DOI 10.1002/ptr.7046
   de Mattos BRR, 2015, MEDIAT INFLAMM, V2015, DOI 10.1155/2015/493012
   Ran YY, 2021, BRAIN RES, V1770, DOI 10.1016/j.brainres.2021.147626
   Rana A, 2018, J NEUROINFLAMM, V15, DOI 10.1186/s12974-018-1192-7
   Rathi S, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01868
   Robinson A, 2019, J CLIN GASTROENTEROL, V53, P65, DOI [10.1097/MCG.0000000000001024, 10.1097/mcg.0000000000001024]
   Rosen ED, 2006, NAT REV MOL CELL BIO, V7, P885, DOI 10.1038/nrm2066
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Rui WJ, 2020, INT J NEUROPSYCHOPH, V23, P762, DOI 10.1093/ijnp/pyaa060
   Ryter SW, 2006, PHYSIOL REV, V86, P583, DOI 10.1152/physrev.00011.2005
   Savarese Gianluigi, 2017, Card Fail Rev, V3, P7, DOI 10.15420/cfr.2016:25:2
   Serpa R, 2012, J MED MICROBIOL, V61, P1704, DOI 10.1099/jmm.0.047852-0
   Shen J, 2019, INT IMMUNOPHARMACOL, V73, P193, DOI 10.1016/j.intimp.2019.04.052
   Shen J, 2021, J ETHNOPHARMACOL, V265, DOI 10.1016/j.jep.2020.113198
   Shen KZ, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/6169128
   Shi HL, 2022, EUR J PHARMACOL, V934, DOI 10.1016/j.ejphar.2022.175270
   Shirley KP, 2017, J PROSTHODONT, V26, P508, DOI 10.1111/jopr.12411
   Singh S, 2017, INT J HYPERTENS, V2017, DOI 10.1155/2017/5491838
   Singh S, 2021, PHARMACOL RES, V164, DOI 10.1016/j.phrs.2020.105387
   Sirven JI, 2015, CSH PERSPECT MED, V5, DOI 10.1101/cshperspect.a022848
   Song LJ, 2022, J FOOD BIOCHEM, V46, DOI 10.1111/jfbc.13703
   Srinivas NR, 2010, XENOBIOTICA, V40, P357, DOI 10.3109/00498251003663724
   Sun HJ, 2020, PHARMACOLOGY, V105, P28, DOI 10.1159/000502614
   Sun WL, 2020, FOOD FUNCT, V11, P711, DOI [10.1039/C9FO02237F, 10.1039/c9fo02237f]
   Tang JL, 2023, INT J NEUROSCI, V133, P1380, DOI 10.1080/00207454.2022.2080676
   Tang R, 1958, Acta Physiol Sin, V22, P91
   Tang YH, 2006, BIOMED CHROMATOGR, V20, P1116, DOI 10.1002/bmc.655
   Vezzani A, 2011, NAT REV NEUROL, V7, P31, DOI 10.1038/nrneurol.2010.178
   Wang CX, 2018, MED SCI MONITOR, V24, P9213, DOI 10.12659/MSM.910347
   Wang H, 2023, J ETHNOPHARMACOL, V301, DOI 10.1016/j.jep.2022.115853
   Wang HZ, 2014, J PHARMACOL EXP THER, V350, P435, DOI 10.1124/jpet.114.215145
   Wang Shu-fang, 2008, Zhongguo Zhong Yao Za Zhi, V33, P1669
   Wang T, 2017, EUR J MED CHEM, V141, P92, DOI 10.1016/j.ejmech.2017.09.049
   Wang W, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19061816
   Wang XY, 2021, INT IMMUNOPHARMACOL, V101, DOI 10.1016/j.intimp.2021.108315
   Wang Y, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/404529
   Wang Y, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0098834
   Xi YL, 2015, CELL PHYSIOL BIOCHEM, V35, P2349, DOI 10.1159/000374037
   Xia CJ, 2020, TOXICOL APPL PHARM, V403, DOI 10.1016/j.taap.2020.115131
   Xiao JR, 2014, J OCUL PHARMACOL TH, V30, P605, DOI 10.1089/jop.2014.0074
   Xiao YC, 2018, ARCH BIOCHEM BIOPHYS, V640, P37, DOI 10.1016/j.abb.2018.01.006
   Xiao ZG, 2021, BIOCHEM PHARMACOL, V190, DOI 10.1016/j.bcp.2021.114594
   Xing Y, 2021, J AGR FOOD CHEM, V69, P9822, DOI 10.1021/acs.jafc.1c04194
   Xue X, 2021, PHARMACOL RES PERSPE, V9, DOI 10.1002/prp2.703
   Yang JL, 2021, DRUG DES DEV THER, V15, P3163, DOI 10.2147/DDDT.S314076
   Yang JY, 2021, PHARMACOL REP, V73, P1230, DOI 10.1007/s43440-021-00227-1
   Yang JR, 2015, CHIN J NAT MEDICINES, V13, P208, DOI 10.1016/S1875-5364(15)30006-6
   Yang LP, 2009, INVEST OPHTH VIS SCI, V50, P2319, DOI 10.1167/iovs.08-2642
   Yang ZC, 2019, EUR J PHARMACOL, V854, P187, DOI 10.1016/j.ejphar.2019.04.005
   Yu RC, 2016, EXP THER MED, V12, P4113, DOI 10.3892/etm.2016.3884
   Yu XD, 2015, J ETHNOPHARMACOL, V162, P69, DOI 10.1016/j.jep.2014.12.041
   Yu Y, 2015, INT J CLIN EXP MED, V8, P8958
   Yu Z, 2016, FEBS OPEN BIO, V6, P1093, DOI 10.1002/2211-5463.12130
   Zandi K, 2021, MICROORGANISMS, V9, DOI 10.3390/microorganisms9050893
   Zandi K, 2012, BMC COMPLEM ALTERN M, V12, DOI 10.1186/1472-6882-12-214
   Zhai H, 2019, J INTEGR NEUROSCI, V18, P423, DOI 10.31083/j.jin.2019.04.192
   Zhang CYY, 2018, INT IMMUNOPHARMACOL, V64, P175, DOI 10.1016/j.intimp.2018.09.001
   Zhang JY, 2015, J CHROMATOGR B, V985, P91, DOI 10.1016/j.jchromb.2015.01.018
   Zhang JL, 2018, LIFE SCI, V192, P46, DOI 10.1016/j.lfs.2017.11.027
   Zhang K, 2016, SCI REP-UK, V6, DOI 10.1038/srep30951
   Zhang L, 2007, EUR J PHARM SCI, V31, P221, DOI 10.1016/j.ejps.2007.04.001
   Zhang QW, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.02142
   Zhang RY, 2017, EUR J DRUG METAB PH, V42, P981, DOI 10.1007/s13318-017-0419-9
   Zhang SP, 2020, MICROB PATHOGENESIS, V139, DOI 10.1016/j.micpath.2019.103899
   Zhang YQ, 2017, CELL PHYSIOL BIOCHEM, V41, P849, DOI 10.1159/000459708
   Zhao JF, 2020, DIABETES VASC DIS RE, V17, DOI 10.1177/1479164120977441
   Zhao WH, 2016, EXP THER MED, V11, P183, DOI 10.3892/etm.2015.2846
   Zhao XY, 2021, BIOMED PHARMACOTHER, V140, DOI 10.1016/j.biopha.2021.111556
   Zhong J, 2019, Braz J Med Biol Res, V52, P2019
   Zhong XC, 2019, J CANCER PREV, V24, P129, DOI 10.15430/JCP.2019.24.2.129
   Zhou QM, 2009, ACTA PHARMACOL SIN, V30, P1648, DOI 10.1038/aps.2009.166
   Zhou QB, 2014, INFLAMMATION, V37, P107, DOI 10.1007/s10753-013-9717-9
   Zhou Y, 2014, PROG NEUROBIOL, V115, P25, DOI 10.1016/j.pneurobio.2013.11.003
   Zhu XH, 2020, FOOD CHEM TOXICOL, V136, DOI 10.1016/j.fct.2019.110990
   Zhu YA, 2021, INVEST OPHTH VIS SCI, V62, DOI 10.1167/iovs.62.6.26
NR 185
TC 7
Z9 7
U1 6
U2 17
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2228-7930
EI 2228-7949
J9 AVICENNA J PHYTOMEDI
JI Avicenna J. Phytomedicine
PD JAN-FEB
PY 2024
VL 14
IS 1
BP 23
EP 49
DI 10.22038/AJP.2023.22307
PG 27
WC Chemistry, Medicinal
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA CK9P2
UT WOS:001125266500010
PM 38948180
DA 2025-06-11
ER

PT J
AU Zhang, CY
   Li, H
   Wang, SX
AF Zhang, Chengyu
   Li, Han
   Wang, Shixiang
TI Common gene signatures and molecular mechanisms of diabetic nephropathy
   and metabolic syndrome
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE transcription data; single-cell analysis; type 2 diabetes; oxidative
   phosphorylation; diabetic nephropathy
ID OXIDATIVE STRESS; KIDNEY-DISEASE; COMPLICATIONS; SUBSETS
AB BackgroundDiabetic nephropathy (DN) is the leading cause of end-stage renal disease. Multiple metabolic toxicities, redox stress, and endothelial dysfunction contribute to the development of diabetic glomerulosclerosis and DN. Metabolic syndrome (MetS) is a pathological state in which the body's ability to process carbohydrates, fats, and proteins is compromised because of metabolic disorders, resulting in redox stress and renal remodeling. However, a causal relationship between MetS and DN has not been proven. This study aimed to provide valuable information for the clinical diagnosis and treatment of MetS with DN. MethodsHere, transcriptome data of DN and MetS patients were obtained from the Gene Expression Omnibus database, and seven potential biomarkers were screened using bioinformatics analysis. In addition, the relationship between these marker genes and metabolism and immune infiltration was explored. Among the identified marker genes, the relationship between PLEKHA1 and the cellular process, oxidative phosphorylation (OXPHOS), in DN was further investigated through single-cell analysis. ResultsWe found that PLEKHA1 may represent an important biomarker that perhaps initiates DN by activating B cells, proximal tubular cells, distal tubular cells, macrophages, and endothelial cells, thereby inducing OXPHOS in renal monocytes. ConclusionOverall, our findings can aid in further investigation of the effects of drug treatment on single cells of patients with diabetes to validate PLEKHA1 as a therapeutic target and to inform the development of targeted therapies.
C1 [Zhang, Chengyu; Li, Han; Wang, Shixiang] Capital Med Univ, Beijing Chao Yang Hosp, Dept Nephrol, Beijing, Peoples R China.
C3 Capital Medical University
RP Li, H (corresponding author), Capital Med Univ, Beijing Chao Yang Hosp, Dept Nephrol, Beijing, Peoples R China.
EM hanli@ccmu.edu.cn
CR Afkarian M, 2016, JAMA-J AM MED ASSOC, V316, P602, DOI 10.1001/jama.2016.10924
   Alhamzawi R, 2018, MATH BIOSCI, V303, P75, DOI 10.1016/j.mbs.2018.06.004
   BAYNES JW, 1991, DIABETES, V40, P405, DOI 10.2337/diabetes.40.4.405
   Chen BB, 2018, METHODS MOL BIOL, V1711, P243, DOI 10.1007/978-1-4939-7493-1_12
   Chuang SM, 2019, DIABETES RES CLIN PR, V153, P6, DOI 10.1016/j.diabres.2019.04.022
   Coughlan MT, 2016, KIDNEY INT, V90, P272, DOI 10.1016/j.kint.2016.02.043
   Coughlan MT, 2016, DIABETES, V65, P1085, DOI 10.2337/db15-0864
   de Boer IH, 2011, JAMA-J AM MED ASSOC, V305, P2532, DOI 10.1001/jama.2011.861
   Der E, 2019, NAT IMMUNOL, V20, P915, DOI 10.1038/s41590-019-0386-1
   Der E, 2017, JCI INSIGHT, V2, DOI 10.1172/jci.insight.93009
   Feng ST, 2022, CLIN KIDNEY J, V15, P534, DOI 10.1093/ckj/sfab186
   Fernandez ML, 2007, NUTR REV, V65, pS30, DOI [10.1111/j.1753-4887.2007.tb00325.x, 10.1301/nr.2007.jun.S30-S34]
   Fineberg D, 2013, NAT REV ENDOCRINOL, V9, P713, DOI 10.1038/nrendo.2013.184
   Gregg EW, 2014, NEW ENGL J MED, V370, P1514, DOI 10.1056/NEJMoa1310799
   Han HJ, 2005, AM J PHYSIOL-RENAL, V288, pF988, DOI 10.1152/ajprenal.00327.2004
   Hastie Trevor, 2023, CRAN
   He HL, 2020, J ALLERGY CLIN IMMUN, V145, P1615, DOI 10.1016/j.jaci.2020.01.042
   Hu YF, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.847760
   Huang CM, 2006, DIABETES, V55, P1826, DOI 10.2337/db05-1438
   Ito K, 2013, CPT-PHARMACOMET SYST, V2, DOI 10.1038/psp.2013.56
   Jia AQ, 2021, BRIEF BIOINFORM, V22, DOI 10.1093/bib/bbab108
   Kashihara N, 2010, CURR MED CHEM, V17, P4256, DOI 10.2174/092986710793348581
   Langfelder P, 2008, BMC BIOINFORMATICS, V9, DOI 10.1186/1471-2105-9-559
   Li JH, 2020, EMBO REP, V21, DOI 10.15252/embr.201948781
   Liberzon A, 2015, CELL SYST, V1, P417, DOI 10.1016/j.cels.2015.12.004
   Liu MM, 2022, ENDOCR METAB IMMUNE, V22, P274, DOI 10.2174/1871530321666210215161921
   microsoft, DOWNL R 4 1 3 WIND
   ncbi, GEO ACC VIEW
   Newman AM, 2015, NAT METHODS, V12, P453, DOI [10.1038/NMETH.3337, 10.1038/nmeth.3337]
   Opazo-Ríos L, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21072632
   Pedersen Thomas Lin, 2024, CRAN
   Rambacher KM, 2020, BIOCHEM PHARMACOL, V171, DOI 10.1016/j.bcp.2019.113690
   Ritchie ME, 2015, NUCLEIC ACIDS RES, V43, DOI 10.1093/nar/gkv007
   Robin X, 2011, BMC BIOINFORMATICS, V12, DOI 10.1186/1471-2105-12-77
   Rohart F, 2017, PLOS COMPUT BIOL, V13, DOI 10.1371/journal.pcbi.1005752
   Salvatore T, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23073651
   Suzuki S, 1999, DIABETES RES CLIN PR, V45, P161, DOI 10.1016/S0168-8227(99)00046-7
   Thongnak L, 2020, AM J MED SCI, V359, P84, DOI 10.1016/j.amjms.2019.11.004
   Thorn LM, 2009, DIABETES CARE, V32, P950, DOI 10.2337/dc08-2022
   Wilson Parker, 2019, GEO
   Wilson PC, 2019, P NATL ACAD SCI USA, V116, P19619, DOI 10.1073/pnas.1908706116
   Woroniecka Karolina, 2011, GEO
   Yuan Jiaming, 2024, CRAN
   Zeng MR, 2019, J CELL PHYSIOL, V234, P16447, DOI 10.1002/jcp.28313
   Zhao EF, 2020, FRONT CARDIOVASC MED, V7, DOI 10.3389/fcvm.2020.586871
NR 45
TC 7
Z9 8
U1 2
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD MAR 30
PY 2023
VL 11
AR 1150122
DI 10.3389/fpubh.2023.1150122
PG 13
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA D3YW9
UT WOS:000968129200001
PM 37143982
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Guerrero-Romero, F
   Rodríguez-Morán, M
AF Guerrero-Romero, Fernando
   Rodriguez-Moran, Martha
TI Hypomagnesemia, oxidative stress, inflammation, and metabotic syndrome
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article
DE metabolic syndrome; inflammation; hypomagnesemia; oxidative stress;
   C-reactive protein; malondialdehyde
ID C-REACTIVE PROTEIN; SERUM MAGNESIUM LEVELS; LIPID-PEROXIDATION; DIETARY
   MAGNESIUM; CALCIUM; INTERLEUKIN-6; CHOLESTEROL; DISEASE; ALPHA
AB Background Although hypomagnesemia, oxidative stress, and inflammation are involved in the pathogenesis of cardiovascular diseases, there is not a previous description concerning their potential interaction; thus, the aim of this study was to examine the relationship between metabolic syndrome (MetS), hypomagnesemia, inflammation, and oxidative stress.
   Methods Case-control design study. incident cases of MetS (84 women and 63 men) were compared with healthy control subjects (163 women and 131 men) matched by age and gender. MetS was diagnosed according to the Adult Treatment Panel III (ATP III) criterion. Oxidative stress was defined by serum malondialdehyde concentration (MDA) >= 50 mg/dL, low-grade chronic inflammation by C-reactive protein (CRP) serum levels >= 3 mg/L, and hypomagnesemia by serum magnesium concentrations <= 1.8 mg/dL.
   Results Multivariate analysis adjusted by age, sex, body mass index, waist-to-hip ratio, and total adiposity showed a strong association between MetS and hypomagnesemia (OR 1.9; 95% CI 1.3-7.1), inflammation (OR 1.7; 95% CI 1.4-8-4), and oxidative stress (OR 1.4; 95% CI 0.9-12.6). Additional adjustment by CRP levels showed that MetS remained associated to hypomagnesemia (OR 1.4; 95% CI 1.1-5.9) but not to oxidative stress (OR 1.1; 95% CI 0.9-5.9), and adjusted by MDA levels, MetS remained strongly associated to hypomagnesemia (1.6; CI 95% 1.1-7.4), but not to inflammation (OR 1.05; 95% CI 0.97-14.2). Adjusted by serum magnesium levels, inflammation (OR 1.2; 95% CI 1.1-9.1) and oxidative stress (OR 1.1; 95% CI 1.1-9-7) were slightly associated to MetS.
   Conclusions The interaction of inflammation and oxidative stress is related and increases the risk for MetS, whereas serum magnesium levels and MetS are independently associated. Copyright (c) 2006 John Wiley & Sons, Ltd.
C1 Mexican Social Secur Inst, Med Res Unit Clin Epidemiol, Res Grp Diabet & Chron Illnesses, Durango, Dgo, Mexico.
C3 Instituto Mexicano del Seguro Social
RP Guerrero-Romero, F (corresponding author), Siqueiros 225 Esq Castaneda, Durango 34000, Dgo, Mexico.
EM guerrero_romero@hotmail.com
CR Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   [Anonymous], CLIN EPIDEMIOLOGY BI
   Ariza AC, 2005, CLIN BIOCHEM, V38, P128, DOI 10.1016/j.clinbiochem.2004.09.018
   Barbagallo Mario, 2003, Molecular Aspects of Medicine, V24, P39, DOI 10.1016/S0098-2997(02)00090-0
   Binder CJ, 2005, J LIPID RES, V46, P1353, DOI 10.1194/jlr.R500005-JLR200
   Black HR, 1997, ARCH INTERN MED, V157, P2413
   BONNEFONT D, 1989, CLIN CHEM, V35, P2054
   Busserolles J, 2003, MAGNESIUM RES, V16, P7
   Cernak I, 2000, J NEUROTRAUM, V17, P53, DOI 10.1089/neu.2000.17.53
   Cernak I, 2000, MAGNESIUM RES, V13, P29
   Delgado AV, 2003, NEUROPEPTIDES, V37, P355, DOI 10.1016/j.npep.2003.09.005
   DONG AC, 1994, J BIOL CHEM, V269, P6424
   FERRANNINI E, 1993, HORM RES, V39, P107, DOI 10.1159/000182795
   Fröhlich M, 2000, DIABETES CARE, V23, P1835, DOI 10.2337/diacare.23.12.1835
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Guerrero-Romero F, 2005, ARCH MED RES, V36, P250, DOI 10.1016/j.arcmed.2005.01.004
   Guerrero-Romero F, 2002, ACTA DIABETOL, V39, P209, DOI 10.1007/s005920200036
   Guerrero-Romero F, 2002, INT J OBESITY, V26, P469, DOI 10.1038/sj.ijo.0801954
   Guerrero-Romero F, 2000, J DIABETES COMPLICAT, V14, P272, DOI 10.1016/S1056-8727(00)00127-6
   Hans Chetan Parkash, 2002, Indian Journal of Experimental Biology, V40, P1275
   Hans CP, 2003, MAGNESIUM RES, V16, P13
   Hansson GK, 2005, NEW ENGL J MED, V352, P1685, DOI 10.1056/NEJMra043430
   Hasebe Naoyuki, 2005, Clin Calcium, V15, P194
   Hutchinson WL, 2000, CLIN CHEM, V46, P934
   ISKRA M, 1993, J TRACE ELEM ELECT H, V7, P185
   Itokawa Yoshinori, 2005, Clin Calcium, V15, P154
   King DE, 2005, J AM COLL NUTR, V24, P166, DOI 10.1080/07315724.2005.10719461
   Kramer JH, 2003, EXP BIOL MED, V228, P665, DOI 10.1177/153537020322800604
   Kulpmann WR, 1996, EUR J CLIN CHEM CLIN, V34, P257
   Macy EM, 1997, CLIN CHEM, V43, P52
   Mak IT, 2003, MAGNESIUM RES, V16, P91
   Miller ER, 1998, CIRCULATION, V98, P2390, DOI 10.1161/01.CIR.98.22.2390
   Pickup JC, 1997, DIABETOLOGIA, V40, P1286, DOI 10.1007/s001250050822
   Rabago-Velasco M, 2000, Gac Med Mex, V136, P23
   Rodríguez-Morán M, 2004, MAGNESIUM RES, V17, P189
   RYZEN E, 1989, J AM COLL NUTR, V8, P580
   Saha H, 1998, CLIN CHEM LAB MED, V36, P715, DOI 10.1515/CCLM.1998.126
   Schiffrin EL, 2005, CIRCULATION, V111, P830, DOI 10.1161/01.CIR.0000157186.95918.78
   Schleicher E, 2005, ANN NY ACAD SCI, V1043, P343, DOI 10.1196/annals.1333.041
   SEELIG MS, 1994, J AM COLL NUTR, V13, P429
   Song YQ, 2005, DIABETES CARE, V28, P1438, DOI 10.2337/diacare.28.6.1438
   Soska V., 1997, REV MEXICANA PATOLOG, V44, P62
   YAGI K, 1976, BIOCHEM MED METAB B, V15, P212, DOI 10.1016/0006-2944(76)90049-1
NR 43
TC 126
Z9 132
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD NOV-DEC
PY 2006
VL 22
IS 6
BP 471
EP 476
DI 10.1002/dmrr.644
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 110BX
UT WOS:000242354400006
PM 16598698
OA Bronze
DA 2025-06-11
ER

PT J
AU García-Carrasco, A
   Izquierdo-Lahuerta, A
   Medina-Gómez, G
AF Garcia-Carrasco, Almudena
   Izquierdo-Lahuerta, Adriana
   Medina-Gomez, Gema
TI The Kidney-Heart Connection in Obesity
SO NEPHRON
LA English
DT Review
DE Obesity; Cardiorenal metabolic syndrome; Kidney; Heart; Endothelium
   hemodynamic changes
AB There is a strong relationship between the kidney and the heart, where if one of these organs fails, so does the other, in the so-called cardiorenal syndrome (CRS). Besides, there are also interactions with the rest of the body leading to a metabolic state that establishes a feedback loop that is perpetuated. The CRS is characterized by hemodynamic changes, activation of neuro-humoral systems, natriuretic peptides, and changes in mineral metabolism. In this scenario, the kidney and heart, connected by a dysfunctional endothelium, inevitably fail. In obesity, this syndrome is exacerbated due to the complications of adipose tissue dysfunction, in the so-called cardiorenal metabolic syndrome (CRMetS). Obesity promotes adipose tissue dysfunction because it exceeds lipid storage capacity and leads to a lipotoxic state, characterized by inflammation, hypertension, insulin resistance and dyslipidemia, oxidative stress, and hyperuricemia, among others, that affect different organs other than the adipose tissue. In addition, the pro-inflammatory gut microbiota present in obese patients releases uremic toxins, contributing to oxidative stress and inflammation, perpetuating and accelerating the progression of this pathology. In this article, we describe the contribution of obesity, the factors and mechanisms implicated in the development of the CRMetS. Despite the great knowledge about the CRS, more research is needed to characterize the CRMetS given the global obesity epidemic.
C1 [Garcia-Carrasco, Almudena; Izquierdo-Lahuerta, Adriana; Medina-Gomez, Gema] Univ Rey Juan Carlos, Fac Ciencias Salud, Dept Ciencias Basicas Salud, Area Bioquim & Biol Mol, Madrid, Spain.
C3 Universidad Rey Juan Carlos
RP Izquierdo-Lahuerta, A; Medina-Gómez, G (corresponding author), Univ Rey Juan Carlos, Fac Ciencias Salud, Dept Ciencias Basicas Salud, Area Bioquim & Biol Mol, Madrid, Spain.
EM adriana.izquierdo@urjc.es; gema.medina@urjc.es
RI GarciaCarrasco, Almudena/LNQ-2317-2024; Medina-Gomez, Gema/F-5667-2016
OI Garcia Carrasco, Almudena/0000-0002-5679-3797
FU Ministerio de Economia y Competitividad de Espana [BFU201678951-R,
   BFU2017-90578-REDT]; Comunidad de Madrid (Spain) [B2017/BMD-3684]
FX Research conducted for this publication was supported by Ministerio de
   Economia y Competitividad de Espana (BFU201678951-R,
   BFU2017-90578-REDT), Comunidad de Madrid (Spain) (B2017/BMD-3684), to
   G.M.G.
CR Aroor AR, 2012, CARDIORENAL MED, V2, P87, DOI 10.1159/000335675
   Cabandugama PK, 2017, MED CLIN N AM, V101, P129, DOI 10.1016/j.mcna.2016.08.009
   Chaudhary K, 2013, CARDIORENAL MED, V3, P208, DOI 10.1159/000355405
   Cosola C, 2018, PHARMACOL RES, V130, P132, DOI 10.1016/j.phrs.2018.03.003
   Costanzo MR, 2020, HEART FAIL CLIN, V16, P81, DOI 10.1016/j.hfc.2019.08.010
   Gupta D, 2011, CARDIORENAL MED, V1, P261, DOI 10.1159/000332388
   Jia GH, 2014, PROG MOL BIOL TRANSL, V127, P229, DOI 10.1016/B978-0-12-394625-6.00009-X
   Jindal A, 2012, CARDIORENAL MED, V2, P314, DOI 10.1159/000343803
   Law JP, 2020, J AM HEART ASSOC, V9, DOI 10.1161/JAHA.120.016041
   Li YC, 2013, SEMIN NEPHROL, V33, P433, DOI 10.1016/j.semnephrol.2013.07.005
   Pazos F, 2020, WORLD J DIABETES, V11, DOI 10.4239/wjd.v11.i8.322
   Pellegrinelli V, 2016, DIABETOLOGIA, V59, P1075, DOI 10.1007/s00125-016-3933-4
   Ronco C, 2012, HEART FAIL REV, V17, P211, DOI 10.1007/s10741-011-9232-8
   Saab G, 2011, CARDIORENAL MED, V1, P123, DOI 10.1159/000327149
   Sowers JR, 2007, KIDNEY INT, V71, P719, DOI 10.1038/sj.ki.5002006
NR 15
TC 10
Z9 10
U1 0
U2 7
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1660-8151
EI 2235-3186
J9 NEPHRON
JI Nephron
PD NOV
PY 2021
VL 145
IS 6
BP 604
EP 608
DI 10.1159/000515419
EA APR 2021
PG 5
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA YZ1ZP
UT WOS:000640282800001
PM 33849028
DA 2025-06-11
ER

PT J
AU Abildgaard, A
   Lund, S
   Hougaard, KS
AF Abildgaard, Anders
   Lund, Sten
   Hougaard, Karin S.
TI Chronic high-fat diet increases acute neuroendocrine stress response
   independently of prenatal dexamethasone treatment in male rats
SO ACTA NEUROPSYCHIATRICA
LA English
DT Article
DE depressive disorder; diet; high-fat; IUGR; model; animals; stress;
   physiological
ID ADRENAL AXIS ACTIVITY; INTRAUTERINE GROWTH RESTRICTION; CATCH-UP GROWTH;
   GLUCOCORTICOID EXPOSURE; PREPULSE INHIBITION; GLUCOSE-INTOLERANCE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; LATE-GESTATION; BIRTH-WEIGHT
AB Objective Intrauterine growth restriction (IUGR) has been associated with metabolic disorders later in life such as obesity and diabetes as well as psychiatric disorders such as depression and schizophrenia. Therefore, we wanted to investigate whether behavioural, metabolic or neuroendocrine abnormalities could be provoked or exacerbated by a high-fat diet (HFD) in an experimental model of IUGR.
   Methods Pregnant dams were exposed to dexamethasone (DEX) in the third gestational week to induce IUGR. Late adolescent male offspring of DEX- and vehicle-treated dams were then fed a HFD or standard chow for 8 weeks and subjected to a variety of assessments.
   Results Only diet affected the hypothalamus-pituitary-adrenal (HPA) axis stress response, as HFD doubled the observed corticosterone levels following acute restraint. HFD and prenatal DEX exposure concomitantly exacerbated depressive-like behaviour in the forced swim test, even though no interaction was seen. Prenatal DEX treatment tended to increase the basal acoustic startle response (ASR), while an interaction between HFD and DEX was present in the ASR pre-pulse inhibition suggestive of fundamental changes in neuronal gating mechanisms. Metabolic parameters were only affected by diet, as HFD increased fasting glucose and insulin levels.
   Conclusion We conclude that chronic HFD may be more important in programming of the HPA axis stress responsiveness than an adverse foetal environment and therefore potentially implies an increased risk for developing psychiatric and metabolic disease.
C1 [Abildgaard, Anders] Aarhus Univ, Translat Neuropsychiat Unit, Risskov, Denmark.
   [Lund, Sten] Aarhus Univ Hosp, Med Dept MEA Endocrinol, DK-8240 Risskov, Denmark.
   [Hougaard, Karin S.] Natl Res Ctr Working Environm, Copenhagen, Denmark.
C3 Aarhus University; Aarhus University; National Research Centre for the
   Working Environment
RP Abildgaard, A (corresponding author), Aarhus Univ Hosp, Translat Neuropsychiat Unit, Skovagervej 2, DK-8240 Risskov, Denmark.
EM anders@dadlnet.dk
RI Abildgaard, Anders/H-2869-2019; Hougaard, Karin Sorig/F-3606-2014
OI Lund, Sten/0000-0002-3805-6267; Hougaard, Karin
   Sorig/0000-0002-3386-0512; Abildgaard, Anders/0000-0001-7272-0953
FU Danish Council for Independent Research (Medical Sciences); Health
   Research Fund of Central Denmark Region; Augustinus Fonden; Aase og
   Ejnar Danielsens Fond; National Research Centre for the Working
   Environment
FX AA was supported by The Danish Council for Independent Research (Medical
   Sciences) and the Health Research Fund of Central Denmark Region. S. L.
   was supported by 'Augustinus Fonden' and 'Aase og Ejnar Danielsens
   Fond'. K. S. H. was supported by the National Research Centre for the
   Working Environment.
CR Abildgaard A, 2011, PSYCHONEUROENDOCRINO, V36, P623, DOI 10.1016/j.psyneuen.2010.09.004
   Akbaraly TN, 2009, BRIT J PSYCHIAT, V195, P408, DOI 10.1192/bjp.bp.108.058925
   Ali S, 2006, DIABETIC MED, V23, P1165, DOI 10.1111/j.1464-5491.2006.01943.x
   Brabham T, 2000, AM J PHYSIOL-REG I, V279, pR1899, DOI 10.1152/ajpregu.2000.279.5.R1899
   Brinkworth GD, 2009, ARCH INTERN MED, V169, P1873, DOI 10.1001/archinternmed.2009.329
   Buettner R, 2007, OBESITY, V15, P798, DOI 10.1038/oby.2007.608
   Buhl ES, 2007, AM J PHYSIOL-ENDOC M, V293, pE1451, DOI 10.1152/ajpendo.00356.2007
   Cannon M, 2002, AM J PSYCHIAT, V159, P1080, DOI 10.1176/appi.ajp.159.7.1080
   Champaneri S, 2013, OBESITY, V21, pE56, DOI 10.1002/oby.20047
   Claessens SEF, 2012, HORM BEHAV, V62, P433, DOI 10.1016/j.yhbeh.2012.07.011
   Cryan JF, 2002, TRENDS PHARMACOL SCI, V23, P238, DOI 10.1016/S0165-6147(02)02017-5
   Desai M, 2011, SEMIN REPROD MED, V29, P237, DOI 10.1055/s-0031-1275517
   DETKE MJ, 1995, PSYCHOPHARMACOLOGY, V121, P66, DOI 10.1007/BF02245592
   Drake AJ, 2010, ENDOCRINOLOGY, V151, P1581, DOI 10.1210/en.2009-1088
   Gale CR, 2004, BRIT J PSYCHIAT, V184, P28, DOI 10.1192/bjp.184.1.28
   Godfrey KM, 2011, SEMIN REPROD MED, V29, P257, DOI 10.1055/s-0031-1275518
   Grillon C, 2008, PSYCHOPHARMACOLOGY, V199, P421, DOI 10.1007/s00213-007-1019-1
   HALES CN, 1992, DIABETOLOGIA, V35, P595, DOI 10.1093/ije/dyt133
   Hauser J, 2006, BEHAV BRAIN RES, V175, P51, DOI 10.1016/j.bbr.2006.07.026
   Hauser J, 2009, HORM BEHAV, V56, P364, DOI 10.1016/j.yhbeh.2009.07.003
   Hougaard KS, 2011, INT J DEV NEUROSCI, V29, P495, DOI 10.1016/j.ijdevneu.2011.01.002
   Hougaard KS, 2005, DEV BRAIN RES, V159, P55, DOI 10.1016/j.devbrainres.2005.06.014
   Hougaard KS, 2005, NEUROTOXICOL TERATOL, V27, P153, DOI 10.1016/j.ntt.2004.08.001
   Jacka FN, 2010, AM J PSYCHIAT, V167, P305, DOI 10.1176/appi.ajp.2009.09060881
   Kamara K, 1998, PHYSIOL BEHAV, V64, P1, DOI 10.1016/S0031-9384(97)00534-9
   Kingston D, 2012, CHILD PSYCHIAT HUM D, V43, P683, DOI 10.1007/s10578-012-0291-4
   Kjaer SL, 2010, DEV NEUROSCI-BASEL, V32, P208, DOI 10.1159/000313914
   Kjær SL, 2010, BRAIN RES, V1320, P106, DOI 10.1016/j.brainres.2010.01.008
   Koch M, 1999, PROG NEUROBIOL, V59, P107, DOI 10.1016/S0301-0082(98)00098-7
   la Fleur SE, 2005, ENDOCRINOLOGY, V146, P2193, DOI 10.1210/en.2004-1603
   Maniam J, 2010, PSYCHONEUROENDOCRINO, V35, P1553, DOI 10.1016/j.psyneuen.2010.05.012
   McMillen IC, 2005, PHYSIOL REV, V85, P571, DOI 10.1152/physrev.00053.2003
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Morrison JL, 2010, PEDIATR NEPHROL, V25, P669, DOI 10.1007/s00467-009-1407-3
   Nagano M, 2008, NEUROSCI RES, V60, P364, DOI 10.1016/j.neures.2007.12.005
   Nyirenda MJ, 1998, J CLIN INVEST, V101, P2174, DOI 10.1172/JCI1567
   O'Regan D, 2004, AM J PHYSIOL-ENDOC M, V287, pE863, DOI 10.1152/ajpendo.00137.2004
   O'Regan D, 2008, J ENDOCRINOL, V196, P343, DOI 10.1677/JOE-07-0327
   Oliveira M, 2006, BIOL PSYCHIAT, V59, P844, DOI 10.1016/j.biopsych.2005.08.020
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pasquali R, 2006, ANN NY ACAD SCI, V1083, P111, DOI 10.1196/annals.1367.009
   Pathan AR, 2008, EUR J PHARMACOL, V589, P176, DOI 10.1016/j.ejphar.2008.06.016
   Pecoraro N, 2004, ENDOCRINOLOGY, V145, P3754, DOI 10.1210/en.2004-0305
   Phillips DIW, 2007, J INTERN MED, V261, P453, DOI 10.1111/j.1365-2796.2007.01801.x
   PORSOLT RD, 1977, NATURE, V266, P730, DOI 10.1038/266730a0
   Rees S, 2008, INT J DEV NEUROSCI, V26, P3, DOI 10.1016/j.ijdevneu.2007.08.020
   REINISCH JM, 1978, SCIENCE, V202, P436, DOI 10.1126/science.705336
   Shahkhalili Y, 2010, AM J PHYSIOL-REG I, V298, pR141, DOI 10.1152/ajpregu.00128.2009
   Sharma S, 2013, INT J OBESITY, V37, P382, DOI 10.1038/ijo.2012.48
   Shoener JA, 2006, AM J PHYSIOL-REG I, V290, pR1366, DOI 10.1152/ajpregu.00757.2004
   Skripuletz T, 2010, INT J DEV NEUROSCI, V28, P561, DOI 10.1016/j.ijdevneu.2010.07.235
   Swerdlow NR, 2008, PSYCHOPHARMACOLOGY, V199, P331, DOI 10.1007/s00213-008-1072-4
   Tannenbaum BM, 1997, AM J PHYSIOL-ENDOC M, V273, pE1168, DOI 10.1152/ajpendo.1997.273.6.E1168
   Ulrich-Lai YM, 2011, PHYSIOL BEHAV, V103, P104, DOI 10.1016/j.physbeh.2010.12.011
   Wallace TM, 2004, DIABETES CARE, V27, P1487, DOI 10.2337/diacare.27.6.1487
   Welberg LAM, 2001, NEUROSCIENCE, V104, P71, DOI 10.1016/S0306-4522(01)00065-3
   WHO, 2003, 05123054 WHO
   Winocur G, 2005, NEUROBIOL AGING, V26, pS46, DOI 10.1016/j.neurobiolaging.2005.09.003
   Wojcik W, 2013, PSYCHOL MED, V43, P1, DOI 10.1017/S0033291712000682
NR 59
TC 21
Z9 21
U1 0
U2 11
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1601-5215
J9 ACTA NEUROPSYCHIATR
JI Acta Neuropsychiatr.
PD FEB
PY 2014
VL 26
IS 1
BP 8
EP 18
DI 10.1017/neu.2013.28
PG 11
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA AA8SZ
UT WOS:000331366500003
PM 25142095
DA 2025-06-11
ER

PT J
AU Pan, MH
   Lai, CS
   Tsai, ML
   Ho, CT
AF Pan, Min-Hsiung
   Lai, Ching-Shu
   Tsai, Mei-Ling
   Ho, Chi-Tang
TI Chemoprevention of nonalcoholic fatty liver disease by dietary natural
   compounds
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Review
DE Chemoprevention; Nonalcoholic fatty liver disease; Dietary natural
   compounds
ID ENDOPLASMIC-RETICULUM STRESS; NECROSIS-FACTOR-ALPHA; MITOCHONDRIAL
   RESPIRATORY-CHAIN; INDUCED INSULIN-RESISTANCE; HEPATIC STELLATE CELLS;
   CIRCULATING INTERLEUKIN-6 LEVELS; INDUCED METABOLIC SYNDROME;
   EICOSAPENTAENOIC ACID EPA; HORMONE-SENSITIVE LIPASE; VISCERAL
   ADIPOSE-TISSUE
AB Nonalcoholic fatty liver disease (NAFLD) refers to a wide spectrum of liver disease that is not from excess alcohol consumption, but is often associated with obesity, type 2 diabetes, and metabolic syndrome. NAFLD pathogenesis is complicated and involves oxidative stress, lipotoxicity, mitochondrial damage, insulin resistance, inflammation, and excessive dietary fat intake, which increase hepatic lipid influx and de novo lipogenesis and impair insulin signaling, thus promoting hepatic triglyceride accumulation and ultimately NAFLD. Overproduction of proinflammatory adipokines from adipose tissue also affects hepatic metabolic function. Current NAFLD therapies are limited; thus, much attention has been focused on identification of potential dietary substances from fruits, vegetables, and edible plants to provide a new strategy for NAFLD treatment. Dietary natural compounds, such as carotenoids, omega-3-PUFAs, flavonoids, isothiocyanates, terpenoids, curcumin, and resveratrol, act through a variety of mechanisms to prevent and improve NAFLD. Here, we summarize and briefly discuss the currently known targets and signaling pathways as well as the role of dietary natural compounds that interfere with NAFLD pathogenesis.
C1 [Pan, Min-Hsiung; Lai, Ching-Shu] Natl Taiwan Univ, Inst Food Sci & Technol, Taipei 10617, Taiwan.
   [Pan, Min-Hsiung] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung, Taiwan.
   [Tsai, Mei-Ling] Natl Kaohsiung Marine Univ, Dept Seafood Sci, Kaohsiung, Taiwan.
   [Ho, Chi-Tang] Rutgers State Univ, Dept Food Sci, New Brunswick, NJ 08903 USA.
C3 National Taiwan University; China Medical University Taiwan; China
   Medical University Hospital - Taiwan; National Kaohsiung University of
   Science & Technology; Rutgers University System; Rutgers University New
   Brunswick
RP Pan, MH (corresponding author), Natl Taiwan Univ, Inst Food Sci & Technol, 1,Sect 4,Roosevelt Rd, Taipei 10617, Taiwan.
EM mhpan@ntu.edu.tw
RI Pan, Min-Hsiung/AAT-8865-2021; Ho, Chi-Tang/B-5629-2012
OI Pan, Min-Hsiung/0000-0002-5188-7030
FU National Science Council [NSC 101-2628-B-022-001-MY4,
   102-2628-B-002-053-MY3]
FX This study was supported by the National Science Council NSC
   101-2628-B-022-001-MY4, 102-2628-B-002-053-MY3.
CR Abu-Elheiga L, 2001, SCIENCE, V291, P2613, DOI 10.1126/science.1056843
   Adams LA, 2010, AM J GASTROENTEROL, V105, P1567, DOI 10.1038/ajg.2010.18
   Ahn J, 2012, MOL NUTR FOOD RES, V56, P1665, DOI 10.1002/mnfr.201200182
   Ahn J, 2008, J HEPATOL, V49, P1019, DOI 10.1016/j.jhep.2008.08.012
   Alberdi G, 2013, NUTRITION, V29, P562, DOI 10.1016/j.nut.2012.09.011
   An J, 2004, NAT MED, V10, P268, DOI 10.1038/nm995
   Anania FA, 2002, HEPATOLOGY, V36, P246, DOI 10.1053/jhep.2002.34359
   Angulo P, 2002, NEW ENGL J MED, V346, P1221, DOI 10.1038/nrdp.2015.80
   Arunkumar E, 2013, PHARM BIOL, V51, P815, DOI 10.3109/13880209.2013.766896
   Assini JM, 2013, J LIPID RES, V54, P711, DOI 10.1194/jlr.M032631
   Awazawa M, 2009, BIOCHEM BIOPH RES CO, V382, P51, DOI 10.1016/j.bbrc.2009.02.131
   Bagul PK, 2012, PHARMACOL RES, V66, P260, DOI 10.1016/j.phrs.2012.05.003
   Bahcecioglu Ibrahim Halil, 2010, Vet Med Int, V2010, DOI 10.4061/2010/262179
   Barreyro FJ, 2007, J BIOL CHEM, V282, P27141, DOI 10.1074/jbc.M704391200
   Bedogni G, 2005, HEPATOLOGY, V42, P44, DOI 10.1002/hep.20734
   Bellentani S, 2010, DIGEST DIS, V28, P155, DOI 10.1159/000282080
   Beppu F, 2013, LIPIDS, V48, P449, DOI 10.1007/s11745-013-3784-4
   Bhala N, 2013, CURR PHARM DESIGN, V19, P5169, DOI 10.2174/13816128113199990336
   BODEN G, 1994, J CLIN INVEST, V93, P2438, DOI 10.1172/JCI117252
   Boden G, 2002, AM J PHYSIOL-ENDOC M, V283, pE12, DOI 10.1152/ajpendo.00429.2001
   Bose M, 2008, J NUTR, V138, P1677, DOI 10.1093/jn/138.9.1677
   Browning JD, 2004, HEPATOLOGY, V40, P1387, DOI 10.1002/hep.20466
   Brunt EM, 1999, AM J GASTROENTEROL, V94, P2467, DOI 10.1111/j.1572-0241.1999.01377.x
   Buechler C, 2011, WORLD J GASTROENTERO, V17, P2801, DOI 10.3748/wjg.v17.i23.2801
   Bujanda L, 2008, BMC GASTROENTEROL, V8, DOI 10.1186/1471-230X-8-40
   Caldwell SH, 1999, J HEPATOL, V31, P430, DOI 10.1016/S0168-8278(99)80033-6
   Canbakan B, 2008, ANN HEPATOL, V7, P249, DOI 10.1016/S1665-2681(19)31856-3
   Ramirez-Tortosa MC, 2009, FREE RADICAL BIO MED, V47, P924, DOI 10.1016/j.freeradbiomed.2009.06.015
   Cazanave SC, 2011, J BIOL CHEM, V286, P39336, DOI 10.1074/jbc.M111.280420
   Cha JY, 2001, PLANT FOOD HUM NUTR, V56, P349, DOI 10.1023/A:1011884200848
   Chakraborty C, 2006, CURR PROTEIN PEPT SC, V7, P113, DOI 10.2174/138920306776359759
   Chalasani N, 2008, J HEPATOL, V48, P829, DOI 10.1016/j.jhep.2008.01.016
   Chen SF, 2012, CAN J PHYSIOL PHARM, V90, P237, DOI [10.1139/Y11-123, 10.1139/y11-123]
   Chen YK, 2011, J AGR FOOD CHEM, V59, P11862, DOI 10.1021/jf2029016
   Chiang SH, 2001, NATURE, V410, P944, DOI 10.1038/35073608
   Chitturi S, 2002, HEPATOLOGY, V36, P403, DOI 10.1053/jhep.2002.34738
   Cho IJ, 2008, BIOCHEM BIOPH RES CO, V367, P190, DOI 10.1016/j.bbrc.2007.12.140
   Cho SJ, 2012, BRIT J NUTR, V108, P2166, DOI 10.1017/S0007114512000347
   Choi SM, 2010, MOL CELL BIOL, V30, P5009, DOI 10.1128/MCB.00797-10
   Choi SK, 2013, NUTR RES PRACT, V7, P26, DOI 10.4162/nrp.2013.7.1.26
   Choudhury J, 2006, METABOLISM, V55, P1317, DOI 10.1016/j.metabol.2006.05.016
   Colicchio P, 2005, ANN NUTR METAB, V49, P289, DOI 10.1159/000087295
   Crespillo A, 2011, BRIT J PHARMACOL, V164, P1899, DOI 10.1111/j.1476-5381.2011.01477.x
   Crespo I, 2008, FOOD CHEM TOXICOL, V46, P1555, DOI 10.1016/j.fct.2007.12.014
   Crespo J, 2001, HEPATOLOGY, V34, P1158, DOI 10.1053/jhep.2001.29628
   Csak T, 2011, HEPATOLOGY, V54, P133, DOI 10.1002/hep.24341
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   Dela Peña A, 2005, GASTROENTEROLOGY, V129, P1663, DOI 10.1053/j.gastro.2005.09.004
   Depner CM, 2013, J NUTR, V143, P315, DOI 10.3945/jn.112.171322
   Dolce CJ, 2009, SURG OBES RELAT DIS, V5, P323, DOI 10.1016/j.soard.2008.12.008
   Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI23621
   Dooley S, 2012, CELL TISSUE RES, V347, P245, DOI 10.1007/s00441-011-1246-y
   Ekstedt M, 2006, HEPATOLOGY, V44, P865, DOI 10.1002/hep.21327
   Fan JG, 2005, J HEPATOL, V43, P508, DOI 10.1016/j.jhep.2005.02.042
   Fedor DM, 2012, METAB SYNDR RELAT D, V10, P175, DOI 10.1089/met.2011.0113
   FEINGOLD KR, 1990, METABOLISM, V39, P623, DOI 10.1016/0026-0495(90)90030-G
   Feldstein AE, 2004, HEPATOLOGY, V40, P185, DOI 10.1002/hep.20283
   Feldstein AE, 2003, GASTROENTEROLOGY, V125, P437, DOI 10.1016/S0016-5085(03)00907-7
   Feldstein AE, 2003, J HEPATOL, V39, P978, DOI 10.1016/S0168-8278(03)00460-4
   Feldstein AE, 2006, AM J PHYSIOL-GASTR L, V290, pG1339, DOI 10.1152/ajpgi.00509.2005
   Fernandez-Real JM, 2001, J CLIN ENDOCR METAB, V86, P1154, DOI 10.1210/jc.86.3.1154
   Fontana L, 2007, DIABETES, V56, P1010, DOI 10.2337/db06-1656
   Friedman JM, 1998, NATURE, V395, P763, DOI 10.1038/27376
   Friedrich M, 2012, INT J OBESITY, V36, P735, DOI 10.1038/ijo.2011.136
   Galic S, 2010, MOL CELL ENDOCRINOL, V316, P129, DOI 10.1016/j.mce.2009.08.018
   Garcea G, 2004, BRIT J CANCER, V90, P1011, DOI 10.1038/sj.bjc.6601623
   George J, 2003, J HEPATOL, V39, P756, DOI 10.1016/S0168-8278(03)00376-3
   Gholam PM, 2007, AM J GASTROENTEROL, V102, P399, DOI 10.1111/j.1572-0241.2006.01041.x
   Gladine C, 2011, BR J NUTR, V107, P1
   Gómez-Zorita S, 2012, BRIT J NUTR, V107, P202, DOI 10.1017/S0007114511002753
   Gornicka A, 2011, ANTIOXID REDOX SIGN, V15, P437, DOI 10.1089/ars.2010.3815
   GUGGER ET, 1992, J NUTR, V122, P115, DOI 10.1093/jn/122.1.115
   Guilherme A, 2008, NAT REV MOL CELL BIO, V9, P367, DOI 10.1038/nrm2391
   Guo HH, 2012, J NUTR BIOCHEM, V23, P349, DOI 10.1016/j.jnutbio.2010.12.013
   Guo HH, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-10
   Guo HH, 2011, J LIPID RES, V52, P908, DOI 10.1194/jlr.M013375
   Harnois F, 2006, OBES SURG, V16, P183, DOI 10.1381/096089206775565122
   Haukeland JW, 2006, J HEPATOL, V44, P1167, DOI 10.1016/j.jhep.2006.02.011
   Higuchi M, 1998, ONCOGENE, V17, P2515, DOI 10.1038/sj.onc.1202485
   Hoek-van den Hil EF, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0051588
   Hosokawa M, 2010, ARCH BIOCHEM BIOPHYS, V504, P17, DOI 10.1016/j.abb.2010.05.031
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Hou XY, 2008, J BIOL CHEM, V283, P20015, DOI 10.1074/jbc.M802187200
   Huang CF, 2011, BRIT J NUTR, V106, P105, DOI 10.1017/S0007114510005799
   Huang HL, 2007, OBES SURG, V17, P1457, DOI 10.1007/s11695-008-9423-0
   Huang XD, 2008, WORLD J GASTROENTERO, V14, P2888, DOI 10.3748/wjg.14.2888
   Hui JM, 2004, HEPATOLOGY, V40, P46, DOI 10.1002/hep.20280
   Huong DTT, 2006, NUTRITION, V22, P546, DOI 10.1016/j.nut.2005.11.006
   Ibrahim MM, 2010, OBES REV, V11, P11, DOI 10.1111/j.1467-789X.2009.00623.x
   Ikejima K, 2002, GASTROENTEROLOGY, V122, P1399, DOI 10.1053/gast.2002.32995
   Inoue Y, 2007, FREE RADICAL RES, V41, P972, DOI 10.1080/10715760701447322
   Ishii H, 2009, J HEPATOL, V50, P562, DOI 10.1016/j.jhep.2008.10.031
   IWATSUKA H, 1970, ENDOCRINOL JAPON, V17, P23
   Janczyk W, 2013, BMC PEDIATR, V13, DOI 10.1186/1471-2431-13-85
   Jeon BT, 2012, DIABETES, V61, P1444, DOI 10.2337/db11-1498
   Jeong SM, 2012, NUTR RES PRACT, V6, P201, DOI 10.4162/nrp.2012.6.3.201
   Ji GY, 2011, INT IMMUNOPHARMACOL, V11, P762, DOI 10.1016/j.intimp.2011.01.036
   Jimba S, 2005, DIABETIC MED, V22, P1141, DOI 10.1111/j.1464-5491.2005.01582.x
   Jung CH, 2013, PHYTOTHER RES, V27, P139, DOI 10.1002/ptr.4687
   Jung TW, 2012, BIOCHEM BIOPH RES CO, V422, P229, DOI 10.1016/j.bbrc.2012.04.129
   Kahn SE, 2003, DIABETOLOGIA, V46, P3, DOI 10.1007/s00125-002-1009-0
   Kajikawa S, 2011, DIGEST DIS SCI, V56, P1065, DOI 10.1007/s10620-010-1400-5
   Kajikawa S, 2010, DIGEST DIS SCI, V55, P631, DOI 10.1007/s10620-009-1020-0
   Kajikawa S, 2009, BBA-MOL CELL BIOL L, V1791, P281, DOI 10.1016/j.bbalip.2009.01.014
   Kameji H, 2010, NUTRITION, V26, P1151, DOI 10.1016/j.nut.2009.09.006
   Kang QH, 2009, LAB INVEST, V89, P1275, DOI 10.1038/labinvest.2009.93
   Kang QH, 2009, BRIT J PHARMACOL, V157, P1354, DOI 10.1111/j.1476-5381.2009.00261.x
   Kang W, 2012, METABOLISM, V61, P424, DOI 10.1016/j.metabol.2011.08.003
   Kim HJ, 2008, MOL NUTR FOOD RES, V52, P965, DOI 10.1002/mnfr.200700315
   Kim JE, 2012, NUTR RES PRACT, V6, P113
   Kim MH, 2011, INT J OBESITY, V35, P1019, DOI 10.1038/ijo.2010.256
   Kim MH, 2010, BRIT J NUTR, V104, P1333, DOI 10.1017/S0007114510002266
   Kim MS, 2012, CURR PHARM BIOTECHNO, V13, P278
   Kim S, 2004, MOL CELL ENDOCRINOL, V220, P51, DOI 10.1016/j.mce.2004.03.011
   KISSEBAH AH, 1994, PHYSIOL REV, V74, P761, DOI 10.1152/physrev.1994.74.4.761
   Klaus S, 2005, INT J OBESITY, V29, P615, DOI 10.1038/sj.ijo.0802926
   Kuda O, 2009, DIABETOLOGIA, V52, P941, DOI 10.1007/s00125-009-1305-z
   Kunimasa K, 2009, BIOORG MED CHEM LETT, V19, P2062, DOI 10.1016/j.bmcl.2009.02.002
   Kuo JJ, 2012, INT J MOL MED, V30, P673, DOI 10.3892/ijmm.2012.1049
   Kuo JJ, 2012, INT J MOL MED, V30, P643, DOI 10.3892/ijmm.2012.1020
   Kuzu N, 2008, J GASTROEN HEPATOL, V23, pE465, DOI 10.1111/j.1440-1746.2007.05052.x
   Kwon YM, 2012, AM J GASTROENTEROL, V107, P1852, DOI 10.1038/ajg.2012.314
   Lam QLK, 2007, CELL MOL IMMUNOL, V4, P1
   Lam TKT, 2002, AM J PHYSIOL-ENDOC M, V283, pE682, DOI 10.1152/ajpendo.00038.2002
   Lamaziere A, 2013, PROSTAG LEUKOTR ESS, V88, P149, DOI 10.1016/j.plefa.2012.12.001
   Leclercq IA, 2002, J HEPATOL, V37, P206, DOI 10.1016/S0168-8278(02)00102-2
   Lee YM, 2006, NUTRITION, V22, P956, DOI 10.1016/j.nut.2005.12.014
   Lee YS, 2013, J NUTR BIOCHEM, V24, P156, DOI 10.1016/j.jnutbio.2012.03.014
   Lee YS, 2010, BIOCHEM PHARMACOL, V79, P1674, DOI 10.1016/j.bcp.2010.01.034
   Lei HW, 2011, J HUAZHONG U SCI-MED, V31, P185, DOI 10.1007/s11596-011-0249-y
   Lemoine M, 2009, LIVER INT, V29, P1431, DOI 10.1111/j.1478-3231.2009.02022.x
   Levene AP, 2012, HISTOPATHOLOGY, V61, P141, DOI 10.1111/j.1365-2559.2011.04145.x
   Li ZZ, 2009, J BIOL CHEM, V284, P5637, DOI 10.1074/jbc.M807616200
   Li ZZ, 2008, HEPATOLOGY, V47, P1495, DOI 10.1002/hep.22183
   Li ZP, 2003, HEPATOLOGY, V37, P343, DOI 10.1053/jhep.2003.50048
   Liew PL, 2008, OBES SURG, V18, P847, DOI 10.1007/s11695-007-9355-0
   Lin CL, 2007, J LIPID RES, V48, P2334, DOI 10.1194/jlr.M700128-JLR200
   Lin JG, 2011, MOL CELL ENDOCRINOL, V333, P160, DOI 10.1016/j.mce.2010.12.028
   Lin JG, 2009, LAB INVEST, V89, P1397, DOI 10.1038/labinvest.2009.115
   Liu JF, 2011, PHYTOTHER RES, V25, P588, DOI 10.1002/ptr.3305
   Louthan MV, 2005, J PEDIATR-US, V147, P835, DOI 10.1016/j.jpeds.2005.07.030
   Luo XY, 2012, BIOCHEM BIOPH RES CO, V417, P287, DOI 10.1016/j.bbrc.2011.11.102
   Luo XQ, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-34
   Madan K, 2006, J CLIN GASTROENTEROL, V40, P930, DOI 10.1097/01.mcg.0000212608.59090.08
   Maeda H, 2009, MOL MED REP, V2, P897, DOI 10.3892/mmr_00000189
   Malhi H, 2006, J BIOL CHEM, V281, P12093, DOI 10.1074/jbc.M510660200
   Malhi H, 2007, GUT, V56, P1124, DOI 10.1136/gut.2006.118059
   Marcolin É, 2013, BASIC CLIN PHARMACOL, V112, P385, DOI 10.1111/bcpt.12049
   Marcolin E, 2012, J NUTR, V142, P1821, DOI 10.3945/jn.112.165274
   Masterton GS, 2010, ALIMENT PHARM THER, V31, P679, DOI 10.1111/j.1365-2036.2010.04230.x
   Matsumoto T, 2010, DIS MODEL MECH, V3, P431, DOI 10.1242/dmm.002311
   McCullough Arthur J, 2004, Clin Liver Dis, V8, P521, DOI 10.1016/j.cld.2004.04.004
   Messner DJ, 2013, DIGEST DIS SCI, V58, P1899, DOI 10.1007/s10620-013-2648-3
   Miyata Y, 2011, LIFE SCI, V88, P613, DOI 10.1016/j.lfs.2011.01.024
   Mohamed Salih S, 2009, J DIABETES, V1, P278, DOI 10.1111/j.1753-0407.2009.00045.x
   Moschen AR, 2010, GUT, V59, P1259, DOI 10.1136/gut.2010.214577
   Mouzaoui S, 2012, INT IMMUNOPHARMACOL, V12, P302, DOI 10.1016/j.intimp.2011.10.010
   Mulvihill EE, 2009, DIABETES, V58, P2198, DOI 10.2337/db09-0634
   Musso G, 2012, DIABETOLOGIA, V55, P885, DOI 10.1007/s00125-011-2446-4
   Musso G, 2010, HEPATOLOGY, V52, P79, DOI 10.1002/hep.23623
   Nanthirudjanar T, 2013, LIPIDS HEALTH DIS, V12, DOI 10.1186/1476-511X-12-73
   Nemoto N, 2009, IN VIVO, V23, P685
   Nettschwander-Tetri BA, 2010, HEPATOLOGY, V52, P913, DOI 10.1002/hep.23784
   Nielsen S, 2004, J CLIN INVEST, V113, P1582, DOI [10.1172/JCI200421047, 10.1172/JCI21047]
   Nissen SE, 2010, ARCH INTERN MED, V170, P1191, DOI 10.1001/archinternmed.2010.207
   Nobili V., 2012, NUTR METAB IN PRESS
   Nobili V, 2011, ARCH DIS CHILD, V96, P350, DOI 10.1136/adc.2010.192401
   Ong JP, 2005, OBES SURG, V15, P310, DOI 10.1381/0960892053576820
   Ono M, 2011, J AGR FOOD CHEM, V59, P13346, DOI 10.1021/jf203490a
   Oya J, 2010, EUR J CLIN NUTR, V64, P1179, DOI 10.1038/ejcn.2010.139
   Pan MH, 2004, J CLIN INVEST, V113, P1277, DOI 10.1172/JCI200419197
   Panchal SK, 2012, J NUTR, V142, P1026, DOI 10.3945/jn.111.157263
   Park SA, 2006, LIFE SCI, V79, P1207, DOI 10.1016/j.lfs.2006.03.022
   Patton HM, 2010, AM J GASTROENTEROL, V105, P2093, DOI 10.1038/ajg.2010.152
   Pérez-Carreras M, 2003, HEPATOLOGY, V38, P999, DOI 10.1053/jhep.2003.50398
   Perlemuter G, 2005, LIVER INT, V25, P946, DOI 10.1111/j.1478-3231.2005.01126.x
   Porepa L, 2010, CAN MED ASSOC J, V182, pE526, DOI 10.1503/cmaj.092144
   Postic C, 2008, J CLIN INVEST, V118, P829, DOI 10.1172/JCI34275
   Poudyal H, 2013, J NUTR BIOCHEM, V24, P1041, DOI 10.1016/j.jnutbio.2012.07.014
   Poulsen MM, 2012, NUTR RES, V32, P701, DOI 10.1016/j.nutres.2012.08.004
   Prashanth M, 2009, J Assoc Physicians India, V57, P205
   Preis SR, 2010, OBESITY, V18, P2191, DOI 10.1038/oby.2010.59
   Pu P, 2012, MOL CELL ENDOCRINOL, V362, P128, DOI 10.1016/j.mce.2012.06.002
   Puigserver P, 2003, NATURE, V423, P550, DOI 10.1038/nature01667
   Puri P, 2008, GASTROENTEROLOGY, V134, P568, DOI 10.1053/j.gastro.2007.10.039
   Qu Xiao-bing, 2008, Zhong Xi Yi Jie He Xue Bao, V6, P711, DOI 10.3736/jcim20080710
   Reaven G, 2004, RECENT PROG HORM RES, V59, P207, DOI 10.1210/rp.59.1.207
   Reddy JK, 2001, ANNU REV NUTR, V21, P193, DOI 10.1146/annurev.nutr.21.1.193
   Rinella Mary E, 2011, Hepatology, V54, P1600, DOI 10.1002/hep.24553
   Sabio G, 2008, SCIENCE, V322, P1539, DOI 10.1126/science.1160794
   Saltiel AR, 2001, NATURE, V414, P799, DOI 10.1038/414799a
   Sánchez-Alcázar JA, 2000, J BIOL CHEM, V275, P13353, DOI 10.1074/jbc.275.18.13353
   Sangeetha RK, 2009, MOL CELL BIOCHEM, V331, P59, DOI 10.1007/s11010-009-0145-y
   Schattenberg JM, 2006, HEPATOLOGY, V43, P163, DOI 10.1002/hep.20999
   Schwabe Robert F, 2004, FASEB J, V18, P720
   Schwarz JM, 2003, AM J CLIN NUTR, V77, P43, DOI 10.1093/ajcn/77.1.43
   Seki S, 2005, HEPATOL RES, V33, P132, DOI 10.1016/j.hepres.2005.09.020
   Senn JJ, 2003, J BIOL CHEM, V278, P13740, DOI 10.1074/jbc.M210689200
   Shang J, 2008, ACTA PHARMACOL SIN, V29, P698, DOI 10.1111/j.1745-7254.2008.00807.x
   Shapiro H, 2005, NUTR RES REV, V18, P212, DOI 10.1079/NRR2005106
   Shiba S, 2011, BIOSCI BIOTECH BIOCH, V75, P2401, DOI 10.1271/bbb.110509
   Shifflet A, 2009, J FORMOS MED ASSOC, V108, P4, DOI 10.1016/S0929-6646(09)60026-7
   Shin ES, 2006, EUR J NUTR, V45, P159, DOI 10.1007/s00394-005-0576-5
   Shin ES, 2007, J NUTR, V137, P1127, DOI 10.1093/jn/137.5.1127
   Smith BW, 2011, NAT REV ENDOCRINOL, V7, P456, DOI 10.1038/nrendo.2011.72
   STRALFORS P, 1989, EUR J BIOCHEM, V182, P379, DOI 10.1111/j.1432-1033.1989.tb14842.x
   Sun C, 2011, MOL BIOL REP, V38, P731, DOI 10.1007/s11033-010-0160-9
   Takahashi Y, 2009, J CLIN BIOCHEM NUTR, V44, P223, DOI 10.3164/jcbn.08-211
   Takayama F, 2010, J OLEO SCI, V59, P407, DOI 10.5650/jos.59.407
   Tanaka N, 2008, J CLIN GASTROENTEROL, V42, P413, DOI 10.1097/MCG.0b013e31815591aa
   Tang X, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-70
   Tang YC, 2010, BRIT J PHARMACOL, V161, P1137, DOI 10.1111/j.1476-5381.2010.00956.x
   Tang YC, 2010, ENDOCRINOLOGY, V151, P4168, DOI 10.1210/en.2010-0191
   Taniguchi CM, 2006, NAT REV MOL CELL BIO, V7, P85, DOI 10.1038/nrm1837
   Tarantino G, 2011, WORLD J GASTROENTERO, V17, P3785, DOI 10.3748/wjg.v17.i33.3785
   Targher G, 2004, CLIN ENDOCRINOL, V61, P700, DOI 10.1111/j.1365-2265.2004.02151.x
   Targher G, 2007, DIABETES CARE, V30, P1212, DOI 10.2337/dc06-2247
   Teufelhofer O, 2005, CARCINOGENESIS, V26, P319, DOI 10.1093/carcin/bgh320
   Tilg H, 2010, HEPATOLOGY, V52, P1836, DOI 10.1002/hep.24001
   Tilg H, 2010, DIGEST DIS, V28, P179, DOI 10.1159/000282083
   Tsuzuki T, 2005, LIPIDS, V40, P1117, DOI 10.1007/s11745-005-1475-0
   Uysal KT, 1997, NATURE, V389, P610, DOI 10.1038/39335
   van der Poorten D, 2008, HEPATOLOGY, V48, P449, DOI 10.1002/hep.22350
   Van Wagner LB, 2011, ANN HEPATOL, V10, P277, DOI 10.1016/S1665-2681(19)31539-X
   VANDERKOOY K, 1993, BRIT J NUTR, V70, P47, DOI 10.1079/BJN19930104
   Varela-Rey M, 2009, INT J BIOCHEM CELL B, V41, P969, DOI 10.1016/j.biocel.2008.10.027
   Vemuri Madhuri, 2007, Metabolic Syndrome and Related Disorders, V5, P315, DOI 10.1089/met.2007.0007
   Vernon G, 2011, ALIMENT PHARM THER, V34, P274, DOI 10.1111/j.1365-2036.2011.04724.x
   Vidyashankar S, 2013, TOXICOL IN VITRO, V27, P945, DOI 10.1016/j.tiv.2013.01.014
   Volkmann X, 2007, HEPATOLOGY, V46, P1498, DOI 10.1002/hep.21846
   Voshol PJ, 2003, ENDOCRINOLOGY, V144, P3456, DOI 10.1210/en.2002-0036
   Wang D, 2006, ENDOCRINOLOGY, V147, P943, DOI 10.1210/en.2005-0570
   Wang GL, 2009, BIOCHEM BIOPH RES CO, V380, P644, DOI 10.1016/j.bbrc.2009.01.163
   Wang JH, 2009, GASTROENTEROLOGY, V137, P713, DOI 10.1053/j.gastro.2009.04.011
   Wang X, 2013, DIABETES CARE, V36, P166, DOI 10.2337/dc12-0702
   Wang Y, 2010, INT J CANCER, V126, P1788, DOI 10.1002/ijc.24689
   Wei YR, 2006, AM J PHYSIOL-ENDOC M, V291, pE275, DOI 10.1152/ajpendo.00644.2005
   Weisberg SP, 2008, ENDOCRINOLOGY, V149, P3549, DOI 10.1210/en.2008-0262
   Weltman MD, 1996, GASTROENTEROLOGY, V111, P1645, DOI 10.1016/S0016-5085(96)70028-8
   Weltman MD, 1998, HEPATOLOGY, V27, P128, DOI 10.1002/hep.510270121
   Wieckowska A, 2008, AM J GASTROENTEROL, V103, P1372, DOI 10.1111/j.1572-0241.2007.01774.x
   Woo MN, 2010, CHEM-BIOL INTERACT, V186, P316, DOI 10.1016/j.cbi.2010.05.006
   Woo MN, 2009, MOL NUTR FOOD RES, V53, P1603, DOI 10.1002/mnfr.200900079
   Xiao J., 2013, Eur J Nutr
   Xu AM, 2003, J CLIN INVEST, V112, P91, DOI 10.1172/JCI200317797
   Yalniz M, 2007, J GASTROEN HEPATOL, V22, P2009, DOI 10.1111/j.1440-1746.2006.04681.x
   Yalniz M, 2007, DIGEST DIS SCI, V52, P2380, DOI 10.1007/s10620-006-9194-1
   Yamaguchi K, 2010, LAB INVEST, V90, P1169, DOI 10.1038/labinvest.2010.75
   Ying HZ, 2013, FOOD CHEM TOXICOL, V52, P53, DOI 10.1016/j.fct.2012.10.030
   Yoo J, 2008, DIABETES RES CLIN PR, V81, P321, DOI 10.1016/j.diabres.2008.05.006
   Zeng Chun-Hua, 2011, Zhonghua Gan Zang Bing Za Zhi, V19, P454
   Zhu FS, 2008, WORLD J GASTROENTERO, V14, P6395, DOI 10.3748/wjg.14.6395
   Zhu W, 2012, FREE RADICAL BIO MED, V52, P314, DOI 10.1016/j.freeradbiomed.2011.10.483
NR 254
TC 80
Z9 95
U1 0
U2 72
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD JAN
PY 2014
VL 58
IS 1
BP 147
EP 171
DI 10.1002/mnfr.201300522
PG 25
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 302GI
UT WOS:000330590100013
PM 24302567
DA 2025-06-11
ER

PT J
AU Cheung, O
   Sanyal, AJ
AF Cheung, Onpan
   Sanyal, Arun J.
TI Recent advances in nonalcoholic fatty liver disease
SO CURRENT OPINION IN GASTROENTEROLOGY
LA English
DT Article
DE insulin resistance; lipid metabolism; metabolic syndrome; nonalcoholic
   steatohepatitis; oxidative stress
ID INTIMA-MEDIA THICKNESS; HEPATOCELLULAR-CARCINOMA; MICRORNA EXPRESSION;
   METABOLIC SYNDROME; CHOLINE-DEFICIENT; WEIGHT-LOSS; STEATOHEPATITIS;
   DIET; FIBROSIS; ACID
AB Purpose of review
   This review focuses on recent advances in the study of the epidemiology, pathogenesis, natural history and treatment of nonalcoholic fatty liver disease (NAFLD).
   Recent findings
   Study of hepatic lipid metabolism, insulin resistance, mitochondrial dysfunction and oxidative stress, genetic variants and predisposition to altered metabolism and cell injury have contributed to our current understanding of NAFLD. Differential expression of microRNA in fatty liver and its implication in disease pathogenesis and therapeutic potential have continued to advance over the year. The pathogenesis of hepatocellular carcinoma in steatohepatitis continues to be explored. The diagnostic utility of imaging and noninvasive markers seems promising in estimating the severity of steatosis and fibrosis. Liver biopsy remains the gold standard for accurately assessing NAFLD and steatohepatitis. Lifestyle modification and weight loss improve both metabolic profile and liver histology. Pharmacotherapy for the treatment of NAFLD remains lacking.
   Summary
   The underlying mechanism and pathogenesis of NAFLD remain elusive despite ongoing researches to make significant advances in the understanding of its natural history, pathogenesis and management. Pharmacotherapy has yet to indicate a promising therapeutic intervention. Current treatment focuses on managing underlying cardio-metabolic risks.
C1 [Cheung, Onpan; Sanyal, Arun J.] Virginia Commonwealth Univ, Med Ctr, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, Richmond, VA USA.
C3 Virginia Commonwealth University
RP Sanyal, AJ (corresponding author), MCV Box 980341, Richmond, VA 23298 USA.
EM ajsanyal@hsc.vcu.edu
FU National Institutes of Health [K24 DK 02755-07]
FX The work was supported in part by a grant from the National Institutes
   of Health to Dr Sanyal K24 DK 02755-07.
CR Abdelmalek MF, 2009, HEPATOLOGY, V50, P1818, DOI 10.1002/hep.23239
   AKYILDIZ M, EUR J GASTR IN PRESS
   Alkhouri Naim, 2009, Expert Rev Gastroenterol Hepatol, V3, P445, DOI 10.1586/egh.09.32
   Amini R, 2009, LIVER INT, V29, P1216, DOI 10.1111/j.1478-3231.2009.02033.x
   ARAYA J, 2009, OBESITY SILVER SPRIN
   Babali A, 2009, HEPATOL INT, V3, P551, DOI 10.1007/s12072-009-9156-8
   Bellentani S, 2008, J HEPATOL, V48, pS338, DOI 10.1016/j.jhep.2008.05.003
   Cassidy FH, 2009, RADIOGRAPHICS, V29, P231, DOI 10.1148/rg.291075123
   Charlton M, 2008, HEPATOLOGY, V47, P484, DOI 10.1002/hep.22063
   CHEN CH, DIG DIS SCI IN PRESS
   Chen CY, 2009, J PROTEOME RES, V8, P463, DOI 10.1021/pr800656e
   Cheng Y, 2009, PHARMACOLOGY, V84, P183, DOI 10.1159/000235873
   Cheng ZY, 2009, NAT MED, V15, P1307, DOI 10.1038/nm.2049
   Cheung O, 2008, HEPATOLOGY, V48, P1810, DOI 10.1002/hep.22569
   Dolganiuc A, 2009, ALCOHOL CLIN EXP RES, V33, P1704, DOI 10.1111/j.1530-0277.2009.01007.x
   Ehman RL, 2009, RADIOLOGY, V253, P1, DOI 10.1148/radiol.2531091040
   Esposito E, 2009, J NUTR, V139, P905, DOI 10.3945/jn.108.101808
   Fisher CD, 2009, DRUG METAB DISPOS, V37, P2087, DOI 10.1124/dmd.109.027466
   Fracanzani AL, 2008, AM J MED, V121, P72, DOI 10.1016/j.amjmed.2007.08.041
   Gao C, 2009, HEPATOB PANCREAT DIS, V8, P465
   George AS, 2009, HEPATOLOGY, V50, P68, DOI 10.1002/hep.22940
   Glimcher LH, 2009, ANN NY ACAD SCI, V1173, pE2, DOI 10.1111/j.1749-6632.2009.04956.x
   Guzman G, 2008, ARCH PATHOL LAB MED, V132, P1761, DOI 10.1043/1543-2165-132.11.1761
   HE S, J BIOL CHEM IN PRESS
   Hu ZW, 2009, ACTA GASTRO-ENT BELG, V72, P215
   Jin X, 2009, DIGEST LIVER DIS, V41, P289, DOI 10.1016/j.dld.2008.08.008
   Johnson NA, 2009, HEPATOLOGY, V50, P1105, DOI 10.1002/hep.23129
   Jun J, 2009, ILAR J, V50, P289, DOI 10.1093/ilar.50.3.289
   Kim HK, 2009, AM J MED SCI, V337, P98, DOI 10.1097/MAJ.0b013e3181812879
   Kim HC, 2009, ATHEROSCLEROSIS, V204, P521, DOI 10.1016/j.atherosclerosis.2008.09.012
   Kotronen A, 2009, DIABETOLOGIA, V52, P1056, DOI 10.1007/s00125-009-1285-z
   LEE JH, DIG LIVER D IN PRESS
   Malik R, 2009, J GASTROEN HEPATOL, V24, P564, DOI 10.1111/j.1440-1746.2008.05731.x
   Mennesson N, 2009, J COMPUT ASSIST TOMO, V33, P672, DOI 10.1097/RCT.0b013e318199d883
   Miele L, 2009, TRANSL RES, V154, P194, DOI 10.1016/j.trsl.2009.06.007
   Miele L, 2009, HEPATOLOGY, V49, P1877, DOI 10.1002/hep.22848
   Nahon P, 2008, J HEPATOL, V49, P1062, DOI 10.1016/j.jhep.2008.08.011
   Oza N, 2009, J GASTROENTEROL, V44, P1203, DOI 10.1007/s00535-009-0115-x
   Patel AA, 2009, J CLIN GASTROENTEROL, V43, P970, DOI 10.1097/MCG.0b013e3181b57475
   Puri P, 2008, GASTROENTEROLOGY, V134, P568, DOI 10.1053/j.gastro.2007.10.039
   Puri P, 2007, HEPATOLOGY, V46, P1081, DOI 10.1002/hep.21763
   Puri P, 2009, HEPATOLOGY, V50, P1827, DOI 10.1002/hep.23229
   Pusl T, 2008, BIOCHEM BIOPH RES CO, V371, P441, DOI 10.1016/j.bbrc.2008.04.113
   Qin XM, 2008, HEPATOLOGY, V48, P432, DOI 10.1002/hep.22334
   Ramilli S, 2009, WORLD J GASTROENTERO, V15, P4770, DOI 10.3748/wjg.15.4770
   Rensen SS, 2009, HEPATOLOGY, V50, P1809, DOI 10.1002/hep.23228
   Rensen SS, 2009, AM J PATHOL, V175, P1473, DOI 10.2353/ajpath.2009.080999
   Ricchi M, 2009, J GASTROEN HEPATOL, V24, P830, DOI 10.1111/j.1440-1746.2008.05733.x
   Romeo S, 2008, NAT GENET, V40, P1461, DOI 10.1038/ng.257
   Salameh N, 2009, RADIOLOGY, V253, P90, DOI 10.1148/radiol.2523081817
   Sanyal AJ, 2005, NAT CLIN PRACT GASTR, V2, P46, DOI 10.1038/ncpgasthep0084
   SANYAL AJ, 2009, RANDOMIZED CONTROLLE
   Shah AG, 2009, CLIN GASTROENTEROL H, V7, P1104, DOI 10.1016/j.cgh.2009.05.033
   Shah K, 2009, OBESITY, V17, P2162, DOI 10.1038/oby.2009.126
   Siegel AB, 2009, CANCER-AM CANCER SOC, V115, P5651, DOI 10.1002/cncr.24687
   Siegmund SV, 2005, HEPATOLOGY, V41, P1085, DOI 10.1002/hep.20667
   Singh R, 2009, AM J PHYSIOL-GASTR L, V297, pG907, DOI 10.1152/ajpgi.00151.2009
   Socha P, 2009, J PEDIATR GASTR NUTR, V48, P587, DOI 10.1097/MPG.0b013e31818e04d1
   Rosselli MS, 2009, ATHEROSCLEROSIS, V206, P119, DOI 10.1016/j.atherosclerosis.2009.01.026
   SOOKOIAN S, ATHEROSCLER IN PRESS
   Sookoian S, 2009, J NUTR BIOCHEM, V20, P765, DOI 10.1016/j.jnutbio.2008.07.005
   Sookoian S, 2009, J LIPID RES, V50, P2111, DOI 10.1194/jlr.P900013-JLR200
   Syn WK, 2009, GASTROENTEROLOGY, V137, P1478, DOI 10.1053/j.gastro.2009.06.051
   Tajiri K, 2009, EUR J GASTROEN HEPAT, V21, P673, DOI 10.1097/MEG.0b013e32831bc3d6
   Velayudham A, 2009, HEPATOLOGY, V49, P989, DOI 10.1002/hep.22711
   Gomez EV, 2009, ALIMENT PHARM THER, V30, P999, DOI 10.1111/j.1365-2036.2009.04122.x
   Villanueva CJ, 2009, HEPATOLOGY, V50, P434, DOI 10.1002/hep.22980
   Wang B, 2009, HEPATOLOGY, V50, P1152, DOI 10.1002/hep.23100
   Witek RP, 2009, HEPATOLOGY, V50, P1421, DOI 10.1002/hep.23167
   Yilmaz Y, 2009, ALIMENT PHARM THER, V30, P1103, DOI 10.1111/j.1365-2036.2009.04148.x
   Yilmaz Y, 2009, EUR J GASTROEN HEPAT, V21, P1247, DOI 10.1097/MEG.0b013e32832b77ae
   Yilmaz Y, 2009, WORLD J GASTROENTERO, V15, P4387, DOI 10.3748/wjg.15.4387
   Yilmaz Y, 2009, HEPATOLOGY, V49, P697, DOI 10.1002/hep.22691
   Yki-Järvinen H, 2009, CURR OPIN LIPIDOL, V20, P477, DOI 10.1097/MOL.0b013e3283321d37
   Yokoo T, 2009, RADIOLOGY, V251, P67, DOI 10.1148/radiol.2511080666
   Yoneda M, 2008, DIGEST LIVER DIS, V40, P371, DOI 10.1016/j.dld.2007.10.019
   Yoneda M, 2009, LIVER INT, V29, P1078, DOI 10.1111/j.1478-3231.2009.01988.x
   Yu Jae-Hee, 2008, J Prev Med Public Health, V41, P407, DOI 10.3961/jpmph.2008.41.6.407
   Zhong L, 2009, J DIG DIS, V10, P315, DOI 10.1111/j.1751-2980.2009.00402.x
NR 79
TC 119
Z9 132
U1 0
U2 22
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0267-1379
EI 1531-7056
J9 CURR OPIN GASTROEN
JI Curr. Opin. Gastroenterol.
PD MAY
PY 2010
VL 26
IS 3
BP 202
EP 208
DI 10.1097/MOG.0b013e328337b0c4
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 592LK
UT WOS:000277380200003
PM 20168226
DA 2025-06-11
ER

PT J
AU Zheng, YX
   Wang, X
   Wang, JY
   Yang, J
   Wang, T
   Li, Q
   Zhu, WZ
   Wang, Y
   Sui, J
   Qiang, W
   Guo, H
   Wang, YA
   Shi, BY
   He, MQ
AF Zheng, Yixuan
   Wang, Xin
   Wang, Jingya
   Yang, Jing
   Wang, Ting
   Li, Qian
   Zhu, Wenzhi
   Wang, Yue
   Sui, Jing
   Qiang, Wei
   Guo, Hui
   Wang, Yanan
   Shi, Bingyin
   He, Mingqian
TI Effects of time-restricted eating and low-carbohydrate diet on
   psychosocial health and appetite in individuals with metabolic syndrome:
   A secondary analysis of a randomized controlled trial
SO CLINICAL NUTRITION
LA English
DT Article
DE Metabolic syndrome; Time-restricted eating; Low-carbohydrate diet;
   Quality of life; Metabolic hormones
ID QUALITY-OF-LIFE; LOW-FAT DIET; WEIGHT-LOSS; REDUCES APPETITE;
   UNITED-STATES; VERY-LOW; OBESITY; PREVALENCE; SATIETY; ADULTS
AB Background & aims: Time-restricted eating (TRE) and low-carbohydrate diet (LCD) can improve multiple cardiometabolic parameters in patients with metabolic syndrome (MetS), but their effects on psychosocial health and satiety are unclear. In this study, we aimed to evaluate the effects of TRE, LCD, and their combination (TRE + LCD) on quality of life (QoL), sleep, mood, appetite, and metabolic hormones in patients with MetS. Methods: This is a secondary analysis of a single-center, 3-month, open-label, randomized clinical trial investigating the effects of TRE, LCD, and TRE + LCD on weight and cardiometabolic parameters in individuals with MetS. This secondary analysis examined QoL, sleep, mood, and appetite using the Rand 36-Item Short Form (SF-36); Pittsburgh Sleep Quality Index (PSQI); Depression, Anxiety, and Stress Scale; and Eating Behavior Rating Scale, respectively, as well as measured levels of metabolic hormones including leptin, amylin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1 (GLP-1), pancreatic polypeptide (PP), and peptide YY. Between-group comparisons were conducted via one-way ANOVAs and post hoc LSD tests for normally distributed variables or Kruskal-Wallis H tests and the Nemenyi test for abnormally distributed variables. P < 0.017 was considered significant in multiple comparisons following Bonferroni adjustment. Results: A total of 162 participants (mean [SD] age, 41.2 [9.9] years; mean [SD] body mass index, 29.3 [3.4] kg/m(2); 102 [63%] men) who started the intervention were analyzed. After 3 months, only the TRE group decreased GLP-1 levels (-0.9 [IQR, -1.9 to -0.3] pg/mL; P = 0.002), increased PP levels (8.9 [IQR, -7.6 to 71.8] pg/mL; P = 0.011), physical functioning in the SF-36 (5.2 [95% CI, 1.9 to 8.5]; P = 0.001), social functioning in the SF-36 (9.1 [95% CI, 2.5 to 15.6]; P = 0.005), role-physical in the SF-36 (24.1 [95% CI, 11.8 to 36.4]; P < 0.001), role-emotional in the SF-36 (22.4 [95% CI, 12.6 to 32.2]; P < 0.001), and sleep efficiency in the PSQI (0.29 [95% CI, 0.03 to 0.55]; P = 0.021). Compared with changes in LCD, TRE further increased general health in the SF-36 (9.7 [95% CI, 3.3 to 16.0]; P = 0.006). Relative to the changes of TRE + LCD, TRE significantly increased role-emotional in the SF-36 (19.9 [95% CI 4.9 to 34.8]; P = 0.006). Changes in sleep quality, mood status, appetite, and metabolic hormones did not differ among three groups. Greater weight loss was associated with decreased leptin levels (r = 0.538), decreased amylin levels (r = 0.294), reduced total appetite scores (r = 0.220), and improved general health (r = -0.253) (all P <= 0.01). Conclusions: TRE, LCD, and TRE + LCD all could improve psychosocial health and reduce appetite. Notably, TRE yielded greater benefits in QoL compared with LCD or TRE + LCD in individuals with MetS. (c) 2024 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Zheng, Yixuan; Yang, Jing; Wang, Yue; Qiang, Wei; Guo, Hui; Wang, Yanan; Shi, Bingyin; He, Mingqian] Xi An Jiao Tong Univ, Af?liated Hosp 1, Dept Endocrinol, 277 West Yanta Rd, Xian 710061, Shaanxi, Peoples R China.
   [Wang, Xin; Yang, Jing; Li, Qian; Zhu, Wenzhi; Wang, Yanan; He, Mingqian] Xi An Jiao Tong Univ, Affiliated Hosp 1, Med X Inst, Ctr Immunol & Metab Dis, 277 West Yanta Rd, Xian 710061, Shaanxi, Peoples R China.
   [Wang, Jingya] Xi An Jiao Tong Univ, Xian Childrens Hosp, Affiliated Childrens Hosp, Shaanxi Res Inst Pediat Dis,Dept Gastroenterol, 69 Xiju Yuan Lane, Xian 710003, Shaanxi, Peoples R China.
   [Wang, Jingya] Natl Reg Med Ctr Children Northwest, 69 Xiju Yuan Lane, Xian 710003, Shaanxi, Peoples R China.
   [Wang, Ting] Shaanxi Prov Peoples Hosp, Dept Cardiovasc Med, 256 Youyi West Rd, Xian 710068, Shaanxi, Peoples R China.
   [Sui, Jing] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Endocrinol, 277 West Yanta Rd, Xian 710061, Shaanxi, Peoples R China.
   [Sui, Jing] Xi An Jiao Tong Univ, Affiliated Hosp 1, Int Med Ctr, 277 West Yanta Rd, Xian 710061, Shaanxi, Peoples R China.
C3 Xi'an Jiaotong University; Xi'an Jiaotong University; Xi'an Jiaotong
   University; Xi'an Medical University; Xi'an Jiaotong University; Xi'an
   Jiaotong University
RP He, MQ (corresponding author), Xi An Jiao Tong Univ, Af?liated Hosp 1, Dept Endocrinol, 277 West Yanta Rd, Xian 710061, Shaanxi, Peoples R China.
EM mingqian_he@xjtufh.edu.cn
RI Wang, Yanan/C-4143-2019; 郭, 卉/JGD-4929-2023
OI Wang, Yanan/0000-0002-0327-0458; He, Mingqian/0009-0003-1239-5740
FU Natural Science Foundation Program of Shaanxi [2024JC-YBQN-0828,
   2023-JC-QN-0927]; Key Research and Development Program of Shaanxi
   [2023-ZDLSF-40]; Fundamental Research Funds of Xi'an Jiaotong University
   [xtr052023011]; China "Thousand Talents Plan" (Young Talents) , Shaanxi
   Province "Thousand Talents Plan" (Young Talents); Foundation of Xi'an
   Jiaotong University (Plan A)
FX This study was supported by the Natural Science Foundation Program of
   Shaanxi (No. 2024JC-YBQN-0828 and 2023-JC-QN-0927) , the Key Research
   and Development Program of Shaanxi (No. 2023-ZDLSF-40) , and the
   Fundamental Research Funds of Xi'an Jiaotong University (No.
   xtr052023011) . Y.-N.W. is supported by the China "Thousand Talents
   Plan" (Young Talents) , Shaanxi Province "Thousand Talents Plan" (Young
   Talents) , and Foundation of Xi'an Jiaotong University (Plan A) .
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Anton SD, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071500
   Batterham RL, 2003, J CLIN ENDOCR METAB, V88, P3989, DOI 10.1210/jc.2003-030630
   Brown RM, 2021, NAT REV ENDOCRINOL, V17, P549, DOI 10.1038/s41574-021-00520-2
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1016/0165-1781(89)90047-4
   Chaudhri OB, 2008, ANNU REV PHYSIOL, V70, P239, DOI 10.1146/annurev.physiol.70.113006.100506
   Chopra S, 2022, DIABETES METAB SYND, V16, DOI 10.1016/j.dsx.2021.102350
   Cohen RV, 2020, LANCET DIABETES ENDO, V8, P937, DOI 10.1016/S2213-8587(20)30370-3
   Crose A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051430
   Cui HX, 2017, NAT REV ENDOCRINOL, V13, P338, DOI 10.1038/nrendo.2016.222
   Despa S, 2012, CIRC RES, V110, P598, DOI [10.1161/CIRCRESAHA.111.258285, 10.1161/circresaha.111.258285]
   Di Rosa C, 2020, OBES RES CLIN PRACT, V14, P491, DOI 10.1016/j.orcp.2020.08.009
   Dietch DM, 2023, BJPSYCH OPEN, V9, DOI 10.1192/bjo.2023.36
   Field R, 2022, PAIN MED, V23, P326, DOI 10.1093/pm/pnab278
   Ford ES, 2008, ANN EPIDEMIOL, V18, P165, DOI 10.1016/j.annepidem.2007.10.009
   Gabel K, 2019, APPL PHYSIOL NUTR ME, V44, P903, DOI 10.1139/apnm-2019-0032
   Guldbrand H, 2014, DIABETES RES CLIN PR, V106, P221, DOI 10.1016/j.diabres.2014.08.032
   Hansen CD, 2023, ANN INTERN MED, V176, P10, DOI 10.7326/M22-1787
   He MQ, 2022, CELL REP MED, V3, DOI 10.1016/j.xcrm.2022.100777
   Holst JJ, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.964406
   Hu T, 2016, NUTR METAB CARDIOVAS, V26, P476, DOI 10.1016/j.numecd.2015.11.011
   Hutchison AT, 2019, OBESITY, V27, P724, DOI 10.1002/oby.22449
   Jamshed H, 2022, JAMA INTERN MED, V182, P953, DOI 10.1001/jamainternmed.2022.3050
   Jensen DE, 2015, PEDIATR OBES, V10, P380, DOI 10.1111/ijpo.275
   Jensen NJ, 2022, CLIN NUTR, V41, P1605, DOI 10.1016/j.clnu.2022.05.005
   Kackley ML, 2022, FRONT NEUROSCI-SWITZ, V16, DOI 10.3389/fnins.2022.971144
   Kämmerer U, 2021, NUTRIENTS, V13, DOI 10.3390/nu13031029
   Kalam F, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010211
   Kesztyüs D, 2020, BMC NUTR, V6, DOI 10.1186/s40795-020-00402-2
   Kleissl-Muir S, 2023, NUTR METAB CARDIOVAS, V33, P2455, DOI 10.1016/j.numecd.2023.08.015
   Kroes M, 2016, CURR MED RES OPIN, V32, P485, DOI 10.1185/03007995.2015.1128403
   Lin SH, 2023, NUTRIENTS, V15, DOI 10.3390/nu15204313
   Longo VD, 2016, CELL METAB, V23, P1048, DOI 10.1016/j.cmet.2016.06.001
   LOVIBOND PF, 1995, BEHAV RES THER, V33, P335, DOI 10.1016/0005-7967(94)00075-U
   Moro T, 2016, J TRANSL MED, V14, DOI 10.1186/s12967-016-1044-0
   Parr EB, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113228
   Qian YJ, 2016, ARCH MED SCI, V12, P1077, DOI 10.5114/aoms.2016.61914
   Ravussin E, 2019, OBESITY, V27, P1244, DOI 10.1002/oby.22518
   Reinehr T, 2007, OBESITY, V15, P2006, DOI 10.1038/oby.2007.239
   Schroder JD, 2021, J TRANSL MED, V19, DOI 10.1186/s12967-020-02687-0
   Srodulski S, 2014, MOL NEURODEGENER, V9, DOI 10.1186/1750-1326-9-30
   Steger FL, 2023, OBESITY, V31, P127, DOI 10.1002/oby.23642
   Struik NA, 2020, J NUTR, V150, P800, DOI 10.1093/jn/nxz344
   Sutton EF, 2018, CELL METAB, V27, P1212, DOI 10.1016/j.cmet.2018.04.010
   Tacad DKM, 2022, ADV NUTR, V13, P792, DOI 10.1093/advances/nmac014
   Varaee H, 2023, J AFFECT DISORDERS, V325, P206, DOI 10.1016/j.jad.2022.12.030
   Vassou C, 2022, NUTR METAB CARDIOVAS, V32, P2195, DOI 10.1016/j.numecd.2022.05.011
   WARE JE, 1992, MED CARE, V30, P473, DOI 10.1097/00005650-199206000-00002
   Warkentin LM, 2014, OBES REV, V15, P169, DOI 10.1111/obr.12113
   Wilkinson MJ, 2020, CELL METAB, V31, P92, DOI 10.1016/j.cmet.2019.11.004
   Xie ZB, 2022, NAT COMMUN, V13, DOI 10.1038/s41467-022-28662-5
   Yamada S, 2021, DIABET METAB SYND OB, V14, P2863, DOI 10.2147/DMSO.S317371
   Zhao SG, 2019, CELL METAB, V30, P706, DOI 10.1016/j.cmet.2019.08.005
   Zhu RX, 2022, CLIN NUTR, V41, P219, DOI 10.1016/j.clnu.2021.11.038
   Zouhal H, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17155600
   Zuo H, 2009, METABOLISM, V58, P1102, DOI 10.1016/j.metabol.2009.04.008
NR 57
TC 4
Z9 4
U1 9
U2 13
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD OCT
PY 2024
VL 43
IS 10
BP 2316
EP 2324
DI 10.1016/j.clnu.2024.08.029
EA SEP 2024
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA F2R3R
UT WOS:001308342200001
PM 39226719
OA hybrid
DA 2025-06-11
ER

PT J
AU Erdamar, H
   Sen, N
   Tavil, Y
   Yazici, HU
   Turfan, M
   Poyraz, F
   Topal, S
   Okuyan, H
   Cemri, M
   Cengel, A
AF Erdamar, Husamettin
   Sen, Nihat
   Tavil, Yusuf
   Yazici, Huseyin Ugur
   Turfan, Murat
   Poyraz, Fatih
   Topal, Salih
   Okuyan, Hizir
   Cemri, Mustafa
   Cengel, Atiye
TI The effect of nebivolol treatment on oxidative stress and antioxidant
   status in patients with cardiac syndrome-X
SO CORONARY ARTERY DISEASE
LA English
DT Article
DE cardiac syndrome-X; free radicals; nebivolol
ID HUMAN ATHEROSCLEROTIC INTIMA; ACUTE CORONARY SYNDROMES; ANGINA-PECTORIS;
   ENDOTHELIAL DYSFUNCTION; NITRIC-OXIDE; HYPERTENSIVE PATIENTS;
   LIPID-PEROXIDATION; CHEST-PAIN; MYELOPEROXIDASE; INACTIVATION
AB Background Free radical-mediated oxidative stress has been implicated in the etiopathogenesis of several disorders. The aim of this study was to elucidate the effect of treatment with nebivolol on the metabolic state of oxidative stress, and antioxidant status markers in patients with cardiac syndrome-X (CSX), additionally, to compare with the effect of metoprolol treatment.
   Methods Thirty patients, 17 female and 13 male, with CSX were enrolled in the study. Nebivolol (5 mg/day) or metoprolol (50 mg/day) was administrated for 12 weeks. Twelve hour fasting blood samples, taken at the initiation and on the third month of therapy, were analyzed for the levels of malondialdehyde WDA), nitrite+nitrate (NOx), and the activity of myeloperoxidase (MPO), superoxide dismutase (SOD). No patient presented additional risk factors for increased reactive oxygen species levels.
   Results Compared with sixteen control participants, patients with CSX had significantly higher activity of MPO and levels of MDA, but significantly lower SOD activity and levels of NOx before treatment. After treatment, MPO activity and MDA levels were significantly reduced; SOD activity and NOx levels were significantly increased with nebivolol but remained unchanged with metoprolol.
   Conclusion We have shown that patients with CSX who taken nebivolol have lower serum MPO activity, levels of MDA and higher serum SOD activity, NOx levels when compared with metoprolol treatment. Exercise stress test parameters were also ameliorated in patients who had taken nebivolol in contrast to metoprolol. Nebivolol treatment may be a novel treatment strategy in cases with CSX in the future. Coron Artery Dis 20:238-244 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Sen, Nihat] Gazi Univ, Fac Med, Dept Cardiol, Sch Med, Ankara, Turkey.
   [Erdamar, Husamettin] Tunceli Govt Hosp, Dept Med Biochem, Tunceli, Turkey.
C3 Gazi University; Tunceli State Hospital
RP Sen, N (corresponding author), Gazi Univ, Fac Med, Dept Cardiol, Sch Med, Ankara, Turkey.
EM nihatdrsen@yahoo.com
RI Turfan, Murat/B-8972-2014; Durakoglugil, Emre/Q-3547-2019; Poyraz,
   Fatih/JZD-3254-2024; okuyan, hizir/LZH-1858-2025
CR Baldus S, 2003, CIRCULATION, V108, P1440, DOI 10.1161/01.CIR.0000090690.67322.51
   Baykal Y, 2003, J HYPERTENS, V21, P1207, DOI 10.1097/00004872-200306000-00022
   Brennan M, 2003, NEW ENGL J MED, V349, P1595, DOI 10.1056/NEJMoa035003
   Brennan ML, 2003, CURR OPIN LIPIDOL, V14, P353, DOI 10.1097/00041433-200308000-00003
   Cai H, 2000, CIRC RES, V87, P840, DOI 10.1161/01.RES.87.10.840
   Campeau L, 2002, CAN J CARDIOL, V18, P371
   Celik T, 2006, J HYPERTENS, V24, P591, DOI 10.1097/01.hjh.0000209993.26057.de
   Cominacini L, 2003, J AM COLL CARDIOL, V42, P1838, DOI 10.1016/j.jacc.2003.06.011
   Crea F, 2004, HEART, V90, P457, DOI 10.1136/hrt.2003.020594
   EGASHIRA K, 1993, NEW ENGL J MED, V328, P1659, DOI 10.1056/NEJM199306103282302
   GLOWICK SP, 1955, METHODS ENZYMOLOGY
   Gur M, 2007, CORONARY ARTERY DIS, V18, P89, DOI 10.1097/MCA.0b013e32801104e8
   Hazen SL, 1997, J CLIN INVEST, V99, P2075, DOI 10.1172/JCI119379
   Ilhan A, 2004, PROG NEURO-PSYCHOPH, V28, P1153, DOI 10.1016/j.pnpbp.2004.06.023
   KEMP HG, 1973, AM J CARDIOL, V32, P375, DOI 10.1016/S0002-9149(73)80150-X
   KRAMER JH, 1984, CIRC RES, V55, P120, DOI 10.1161/01.RES.55.1.120
   Leeuwenburgh C, 1997, J BIOL CHEM, V272, P1433, DOI 10.1074/jbc.272.3.1433
   Mangrella M, 1998, PHARMACOL RES, V38, P419, DOI 10.1006/phrs.1998.0387
   MASERI A, 1991, J AM COLL CARDIOL, V17, P499, DOI 10.1016/S0735-1097(10)80122-6
   Mason RP, 2005, CIRCULATION, V112, P3795, DOI 10.1161/CIRCULATIONAHA.105.556233
   Miranda KM, 2001, NITRIC OXIDE-BIOL CH, V5, P62, DOI 10.1006/niox.2000.0319
   Oelze M, 2006, HYPERTENSION, V48, P677, DOI 10.1161/01.HYP.0000239207.82326.29
   On YK, 2005, CIRC J, V69, P1212, DOI 10.1253/circj.69.1212
   Panting JR, 2002, NEW ENGL J MED, V346, P1948, DOI 10.1056/NEJMoa012369
   Pasini Anna Fratta, 2005, Journal of Hypertension, V23, P589, DOI 10.1097/01.hjh.0000160216.86597.ff
   RAJGURU SU, 1994, LIFE SCI, V54, P149, DOI 10.1016/0024-3205(94)00584-2
   Rosen SD, 2002, HEART, V87, P513, DOI 10.1136/heart.87.6.513
   Setoguchi S, 2001, J AM COLL CARDIOL, V38, P493, DOI 10.1016/S0735-1097(01)01382-1
   Sugiyama S, 2001, AM J PATHOL, V158, P879, DOI 10.1016/S0002-9440(10)64036-9
   SUN Y, 1988, CLIN CHEM, V34, P497
   Thukkani AK, 2003, CIRCULATION, V108, P3128, DOI 10.1161/01.CIR.0000104564.01539.6A
   Troost R, 2000, BRIT J CLIN PHARMACO, V50, P377, DOI 10.1046/j.1365-2125.2000.00258.x
   Van Nueten L, 1998, J HUM HYPERTENS, V12, P135, DOI 10.1038/sj.jhh.1000571
   VANDEWATER A, 1988, J CARDIOVASC PHARM, V11, P552, DOI 10.1097/00005344-198805000-00007
   YOSHIOKA T, 1979, AM J OBSTET GYNECOL, V135, P372, DOI 10.1016/0002-9378(79)90708-7
   Zhang ZL, 2001, JAMA-J AM MED ASSOC, V286, P2136, DOI 10.1001/jama.286.17.2136
NR 36
TC 36
Z9 37
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0954-6928
EI 1473-5830
J9 CORONARY ARTERY DIS
JI Coronary Artery Dis.
PD MAY
PY 2009
VL 20
IS 3
BP 238
EP 244
DI 10.1097/MCA.0b013e32830936bb
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 442XU
UT WOS:000265874800010
PM 19396947
DA 2025-06-11
ER

PT J
AU Gupta, A
   Uribarri, J
AF Gupta, Anshu
   Uribarri, Jaime
TI Dietary Advanced Glycation End Products and Their Potential Role in
   Cardiometabolic Disease in Children
SO HORMONE RESEARCH IN PAEDIATRICS
LA English
DT Review
DE Obesity; Children; Insulin resistance; Metabolic syndrome; Advanced
   glycation end products; Receptor of advanced glycation end products
ID OXIDATIVE STRESS; INSULIN SENSITIVITY; OBESE CHILDREN; DIABETIC
   ATHEROSCLEROSIS; GLYCOXIDATION PRODUCTS; GENE POLYMORPHISMS;
   RISK-FACTORS; LIFE-STYLE; RAGE AXIS; MICE
AB The rising incidence of obesity and metabolic diseases such as diabetes mellitus and cardiovascular disease in adolescents and young adults is of grave concern. Recent studies favor a role of lifestyle factors over genetics in the perpetuation of inflammation, insulin resistance and oxidative stress, which are pathophysiologic processes common to the above diseases; furthermore, the importance of dietary factors in addition to calories and physical activity in these processes is being increasingly recognized. Advanced glycation end products (AGEs) belong to a category of dietary oxidants which have been implicated in the pathogenesis of inflammation, oxidative stress, insulin resistance, beta-cell failure and endothelial dysfunction. This paper reviews the studies of AGEs with a focus on their role in cardiometabolic disease in children. A Medline search was performed using the key words 'childhood obesity', 'metabolic syndrome' and 'advanced glycation end products'. Articles published in English between 1975 and 2015 and their references were reviewed. While most studies were performed in adults, a few studies also demonstrated a role of AGEs in obesity and associated cardiometabolic comorbidities in the younger population. Available evidence suggests an involvement of AGEs in the pathogenesis of adiposity and beta-cell failure in children. Potential areas for further research to investigate underlying mechanisms are proposed. (C) 2016 S. Karger AG, Basel
C1 [Gupta, Anshu] Virginia Commonwealth Univ, Dept Pediat, Richmond, VA USA.
   [Uribarri, Jaime] Icahn Sch Med Mt Sinai, Dept Med, Div Nephrol, New York, NY 10029 USA.
C3 Virginia Commonwealth University; Icahn School of Medicine at Mount
   Sinai
RP Gupta, A (corresponding author), POB 980140, Richmond, VA 23298 USA.
EM Anshu.gupta@vcuhealth.org
RI Uribarri, Jaime/ADX-7655-2022
OI uribarri, jaime/0000-0001-9826-1134
FU National Institutes of Health [KL2TR000057]
FX A. G. was supported by KL2TR000057 as part of an institutional Clinical
   and Translational Science Award to Virginia Commonwealth University by
   the National Institutes of Health. The sponsor did not have any role in
   any part of the preparation of this article.
CR Accacha S, 2013, HORM RES PAEDIAT, V80, P318, DOI 10.1159/000354831
   Arslanian S, 2013, DIABETES CARE, V36, P1749, DOI 10.2337/dc12-2393
   Barile GR, 2005, INVEST OPHTH VIS SCI, V46, P2916, DOI 10.1167/iovs.04-1409
   BERENSON GS, 1992, AM J CARDIOL, V70, P851, DOI 10.1016/0002-9149(92)90726-F
   Beyan H, 2012, DIABETES, V61, P1192, DOI 10.2337/db11-0971
   Birlouez-Aragon I, 2010, AM J CLIN NUTR, V91, P1220, DOI 10.3945/ajcn.2009.28737
   Boor P, 2010, CLIN CHIM ACTA, V411, P1034, DOI 10.1016/j.cca.2010.03.033
   Bucciarelli LG, 2002, CIRCULATION, V106, P2827, DOI 10.1161/01.CIR.0000039325.03698.36
   Cai WJ, 2008, AM J PHYSIOL-CELL PH, V294, pC145, DOI 10.1152/ajpcell.00350.2007
   Cai WJ, 2012, P NATL ACAD SCI USA, V109, P15888, DOI 10.1073/pnas.1205847109
   Cai WJ, 2002, MOL MED, V8, P337, DOI 10.1007/BF03402014
   Chen YJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0066611
   Chiavaroli V, 2012, DIABETES CARE, V35, P1361, DOI 10.2337/dc11-2302
   D'Adamo E, 2013, FREE RADICAL RES, V47, P146, DOI 10.3109/10715762.2012.755262
   D'Adamo E, 2011, ANTIOXID REDOX SIGN, V14, P1167, DOI 10.1089/ars.2010.3719
   de Giorgis T, 2012, ANTIOXID REDOX SIGN, V17, P187, DOI 10.1089/ars.2012.4525
   Fehrenbach H, 2001, HEPATOLOGY, V34, P943, DOI 10.1053/jhep.2001.28788
   Goldberg T, 2004, J AM DIET ASSOC, V104, P1287, DOI 10.1016/j.jada.2004.05.214
   Hansen B, 2002, DIABETOLOGIA, V45, P1379, DOI 10.1007/s00125-002-0912-8
   He CJ, 1999, DIABETES, V48, P1308, DOI 10.2337/diabetes.48.6.1308
   Hofmann SM, 2002, DIABETES, V51, P2082, DOI 10.2337/diabetes.51.7.2082
   Hyogo H, 2008, CURR PHARM DESIGN, V14, P969, DOI 10.2174/138161208784139701
   Hyogo H, 2007, J GASTROEN HEPATOL, V22, P1112, DOI 10.1111/j.1440-1746.2007.04943.x
   Kalea AZ, 2009, CLIN SCI, V116, P621, DOI 10.1042/CS20080494
   Klenovics KS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0053056
   Koschinsky T, 1997, P NATL ACAD SCI USA, V94, P6474, DOI 10.1073/pnas.94.12.6474
   Lin N, 2012, DIABETES METAB, V38, P250, DOI 10.1016/j.diabet.2012.01.003
   Lin RY, 2003, ATHEROSCLEROSIS, V168, P213, DOI 10.1016/S0021-9150(03)00050-9
   Lin RY, 2002, ATHEROSCLEROSIS, V163, P303, DOI 10.1016/S0021-9150(02)00008-4
   Mericq V, 2010, DIABETES CARE, V33, P2232, DOI 10.2337/dc10-1058
   Miele C, 2003, J BIOL CHEM, V278, P47376, DOI 10.1074/jbc.M301088200
   Negrean M, 2007, AM J CLIN NUTR, V85, P1236, DOI 10.1093/ajcn/85.5.1236
   Olshansky SJ, 2005, NEW ENGL J MED, V352, P1138, DOI 10.1056/NEJMsr043743
   Park' L, 1998, NAT MED, V4, P1025, DOI 10.1038/2012
   Peppa M, 2003, DIABETES, V52, P1441, DOI 10.2337/diabetes.52.6.1441
   Puddu A, 2010, BIOCHEM BIOPH RES CO, V398, P462, DOI 10.1016/j.bbrc.2010.06.100
   Sandu O, 2005, DIABETES, V54, P2314, DOI 10.2337/diabetes.54.8.2314
   Sebeková K, 2003, AM J KIDNEY DIS, V41, pS48, DOI 10.1053/ajkd.2003.50084
   Sebeková K, 2009, INT J PEDIATR OBES, V4, P112, DOI 10.1080/17477160802248039
   Stirban A, 2006, DIABETES CARE, V29, P2064, DOI 10.2337/dc06-0531
   Turner RC, 1998, LANCET, V352, P837, DOI 10.1016/s0140-6736(98)07019-6
   Unoki H, 2007, DIABETES RES CLIN PR, V76, P236, DOI 10.1016/j.diabres.2006.09.016
   Uribarri J, 2015, J CLIN ENDOCR METAB, V100, P1957, DOI 10.1210/jc.2014-3925
   Uribarri J, 2011, DIABETES CARE, V34, P1610, DOI 10.2337/dc11-0091
   Viviani GL, 2008, METABOLISM, V57, P163, DOI 10.1016/j.metabol.2007.08.020
   Vlassara H, 2002, P NATL ACAD SCI USA, V99, P15596, DOI 10.1073/pnas.242407999
   Vlassara H, 2009, J CLIN ENDOCR METAB, V94, P4483, DOI 10.1210/jc.2009-0089
   Wu JC, 2011, J ENDOCRINOL INVEST, V34, pE343, DOI 10.3275/7856
   Yamagishi Sho-ichi, 2010, Front Biosci (Elite Ed), V2, P1184
   Yan SF, 2010, CIRC RES, V106, P842, DOI 10.1161/CIRCRESAHA.109.212217
   Zheng F, 2002, DIABETES-METAB RES, V18, P224, DOI 10.1002/dmrr.283
NR 51
TC 28
Z9 30
U1 1
U2 11
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1663-2818
EI 1663-2826
J9 HORM RES PAEDIAT
JI Horm. Res. Paediatr.
PY 2016
VL 85
IS 5
BP 291
EP 300
DI 10.1159/000444053
PG 10
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA DO7YO
UT WOS:000377999200001
PM 27008270
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Barbalho, SM
   Direito, R
   Laurindo, LF
   Marton, LT
   Guiguer, EL
   Goulart, RD
   Tofano, RJ
   Carvalho, ACA
   Flato, UAP
   Tofano, VAC
   Detregiachi, CRP
   Bueno, PCS
   Girio, RSJ
   Araújo, AC
AF Barbalho, Sandra Maria
   Direito, Rosa
   Laurindo, Lucas Fornari
   Marton, Ledyane Taynara
   Guiguer, Elen Landgraf
   Goulart, Ricardo de Alvares
   Tofano, Ricardo Jose
   Carvalho, Antonely C. A.
   Prync Flato, Uri Adrian
   Capelluppi Tofano, Viviane Alessandra
   Penteado Detregiachi, Claudia Rucco
   Santos Bueno, Patricia C.
   Girio, Raul S. J.
   Araujo, Adriano Cressoni
TI Ginkgo biloba in the Aging Process: A Narrative Review
SO ANTIOXIDANTS
LA English
DT Article
DE Gingko biloba; aging; neurodegenerative diseases; Alzheimer's disease;
   metabolic syndrome; cardiovascular disease; cancer
ID MILD COGNITIVE IMPAIRMENT; EXTRACT EGB 761(R); NF-KAPPA-B; WESTERN
   MEDICINE THERAPY; DOUBLE-BLIND; METABOLIC SYNDROME; INDUCED APOPTOSIS;
   OXIDATIVE STRESS; MOLECULAR-MECHANISMS; INSULIN-RESISTANCE
AB Neurodegenerative diseases, cardiovascular disease (CVD), hypertension, insulin resistance, cancer, and other degenerative processes commonly appear with aging. Ginkgo biloba (GB) is associated with several health benefits, including memory and cognitive improvement, in Alzheimer's disease (AD), Parkinson's disease (PD), and cancer. Its antiapoptotic, antioxidant, and anti-inflammatory actions have effects on cognition and other conditions associated with aging-related processes, such as insulin resistance, hypertension, and cardiovascular conditions. The aim of this study was to perform a narrative review of the effects of GB in some age-related conditions, such as neurodegenerative diseases, CVD, and cancer. PubMed, Cochrane, and Embase databases were searched, and the PRISMA guidelines were applied. Fourteen clinical trials were selected; the studies showed that GB can improve memory, cognition, memory scores, psychopathology, and the quality of life of patients. Moreover, it can improve cerebral blood flow supply, executive function, attention/concentration, non-verbal memory, and mood, and decrease stress, fasting serum glucose, glycated hemoglobin, insulin levels, body mass index, waist circumference, biomarkers of oxidative stress, the stability and progression of atherosclerotic plaques, and inflammation. Therefore, it is possible to conclude that the use of GB can provide benefits in the prevention and treatment of aging-related conditions.
C1 [Barbalho, Sandra Maria; Guiguer, Elen Landgraf; Goulart, Ricardo de Alvares; Tofano, Ricardo Jose; Carvalho, Antonely C. A.; Prync Flato, Uri Adrian; Penteado Detregiachi, Claudia Rucco; Santos Bueno, Patricia C.; Araujo, Adriano Cressoni] Univ Marilia UNIMAR, Postgrad Program Struct & Funct Interact Rehabil, BR-17525902 Marilia, SP, Brazil.
   [Barbalho, Sandra Maria; Laurindo, Lucas Fornari; Marton, Ledyane Taynara; Guiguer, Elen Landgraf; Tofano, Ricardo Jose; Prync Flato, Uri Adrian; Capelluppi Tofano, Viviane Alessandra; Araujo, Adriano Cressoni] Univ Marilia UNIMAR, Sch Med, Dept Biochem & Pharmacol, Ave Higino Muzzi Filho 1001, BR-17525902 Marilia, SP, Brazil.
   [Barbalho, Sandra Maria; Guiguer, Elen Landgraf] Sch Food & Technol Marilia FATEC, Ave Castro Alves, BR-17500000 Marilia, SP, Brazil.
   [Direito, Rosa] Univ Lisbon, Fac Farm, Res Inst Med iMed ULisboa, Lab Syst Integrat Pharmacol Clin & Regulatory Sci, Av Prof Gama Pinto, P-1649003 Lisbon, Portugal.
   [Santos Bueno, Patricia C.; Girio, Raul S. J.] Univ Marilia UNIMAR, Sch Vet Med, Dept Anim Sci, Ave Higino Muzzi Filho 1001, BR-17525902 Marilia, SP, Brazil.
C3 Universidade de Marilia; Universidade de Marilia; Universidade de
   Lisboa; Universidade de Marilia
RP Barbalho, SM (corresponding author), Univ Marilia UNIMAR, Postgrad Program Struct & Funct Interact Rehabil, BR-17525902 Marilia, SP, Brazil.; Barbalho, SM (corresponding author), Univ Marilia UNIMAR, Sch Med, Dept Biochem & Pharmacol, Ave Higino Muzzi Filho 1001, BR-17525902 Marilia, SP, Brazil.; Barbalho, SM (corresponding author), Sch Food & Technol Marilia FATEC, Ave Castro Alves, BR-17500000 Marilia, SP, Brazil.
EM smbarbalho@gmail.com; rdireito@ff.ulisboa.pt; 1851730@unimar.br;
   1813975@unimar.br; eleng@unimar.br; rgoulart@unimar.br;
   ricardo.tofano@unimar.br; antonely.prefeito@ibaiti.pr.gov.br;
   uriflato@unimar.br; viviane.tofano@unimar.br;
   claudia.detregiachi@unimar.br; patriciabueno@unimar.br;
   rgirio@unimar.br; araujo.01@unimar.br
RI Flato, Uri/AAY-3595-2020; FORNARI LAURINDO, LUCAS/AAC-8677-2022; dos
   Santos Bueno, Patricia/T-5055-2019; Guiguer, Elen/AAN-1883-2020;
   barbalho, sandra/Z-3515-2019; Araujo, Adriano/AAN-1823-2020; Direito,
   Rosa/S-4473-2019; Girio, Raul/M-9085-2018
OI FORNARI LAURINDO, LUCAS/0000-0003-3159-0982; Guiguer,
   Elen/0000-0002-9930-9694; barbalho, sandra/0000-0002-5035-876X; Araujo,
   Adriano/0000-0002-5716-2444; Direito, Rosa/0000-0002-4143-4302; Prync
   Flato, Uri Adrian/0000-0002-8381-8830; Girio, Raul/0000-0002-8845-8985
CR Abdul-Latif R, 2021, J INTEGR MED-JIM, V19, P300, DOI 10.1016/j.joim.2021.03.007
   Almatroodi SA, 2021, MOLECULES, V26, DOI 10.3390/molecules26051315
   An Xiao-fei, 2016, Zhongguo Zhong Xi Yi Jie He Za Zhi, V36, P674
   [Anonymous], 2001, Nutr. Clin. Care, DOI DOI 10.1046/J.1523-5408.2001.00135.X
   Arslan J, 2020, FRONT AGING NEUROSCI, V12, DOI 10.3389/fnagi.2020.00231
   Attia A, 2012, J NEURO-ONCOL, V109, P357, DOI 10.1007/s11060-012-0901-9
   Aziz TA, 2018, DRUG DES DEV THER, V12, P735, DOI 10.2147/DDDT.S157113
   Baek SH, 2017, J CELL PHYSIOL, V232, P346, DOI 10.1002/jcp.25426
   Baek SJ, 2021, NUTRIENTS, V13, DOI 10.3390/nu13061881
   Banin RM, 2014, BRAZ J MED BIOL RES, V47, P780, DOI 10.1590/1414-431X20142983
   Barbalho SM, 2021, EXP GERONTOL, V148, DOI 10.1016/j.exger.2021.111302
   Barbalho SM, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21103607
   Beck SM, 2016, HUM PSYCHOPHARM CLIN, V31, P227, DOI 10.1002/hup.2534
   Belwal T, 2019, NONVITAMIN AND NONMINERAL NUTRITIONAL SUPPLEMENTS, P241, DOI 10.1016/B978-0-12-812491-8.00035-7
   Boots AW, 2011, CLIN NUTR, V30, P506, DOI 10.1016/j.clnu.2011.01.010
   Borenstein R, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-61700-0
   Butler R., 2012, BMJ Clinical Evidence, V2012, P1001
   Carrizzo A, 2020, J AM HEART ASSOC, V9, DOI 10.1161/JAHA.119.014923
   Chan WH, 2007, INT J MOL SCI, V8, P1177, DOI 10.3390/i8111177
   Chen S, 2016, MEDIAT INFLAMM, V2016, DOI 10.1155/2016/9340637
   Chen X, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10061309
   Choudhary Sunayna, 2013, Pharmacogn Rev, V7, P81, DOI 10.4103/0973-7847.120505
   D'Mello SR, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22115911
   de Souza GA, 2020, PLANTA MED, V86, P376, DOI 10.1055/a-1109-3405
   De Strooper B, 2016, CELL, V164, P603, DOI 10.1016/j.cell.2015.12.056
   Dong Zhen-Hua, 2012, Zhongguo Zhong Xi Yi Jie He Za Zhi, V32, P1208
   Eckert A, 2005, ANN NY ACAD SCI, V1056, P474, DOI 10.1196/annals.1352.023
   Edler MK, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10051138
   Eisvand F, 2020, PHYTOTHER RES, V34, P1798, DOI 10.1002/ptr.6646
   Ferenczyova K, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21051585
   Gallardo G, 2019, ADV EXP MED BIOL, V1184, P187, DOI 10.1007/978-981-32-9358-8_16
   García-Mediavilla V, 2007, EUR J PHARMACOL, V557, P221, DOI 10.1016/j.ejphar.2006.11.014
   Gauthier S, 2014, CLIN INTERV AGING, V9, P2065, DOI 10.2147/CIA.S72728
   Gavrilova SI, 2014, INT J GERIATR PSYCH, V29, P1087, DOI 10.1002/gps.4103
   Giovannini MG, 2021, J CLIN MED, V10, DOI 10.3390/jcm10112358
   Gong G, 2020, BIOMED PHARMACOTHER, V128, DOI 10.1016/j.biopha.2020.110301
   Gong Qi-hai, 2006, Chin J Integr Med, V12, P37
   Gregory J, 2021, BIOMOLECULES, V11, DOI 10.3390/biom11040543
   Grewal AK, 2021, BIOMED PHARMACOTHER, V140, DOI 10.1016/j.biopha.2021.111729
   Gschwind Y, 2017, AGING CLIN EXP RES, V29, P609, DOI 10.1007/s40520-016-0699-y
   Gu JH, 2012, EUR J PHARM SCI, V47, P652, DOI 10.1016/j.ejps.2012.07.016
   Guimaraes GR, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10061323
   Hajam YA, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11030552
   Herrschaft H, 2012, J PSYCHIATR RES, V46, P716, DOI 10.1016/j.jpsychires.2012.03.003
   Hirata BKS, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.00686
   Hua ZB, 2017, BMC BIOTECHNOL, V17, DOI 10.1186/s12896-016-0324-3
   Huang WC, 2018, SAUDI PHARM J, V26, P1178, DOI 10.1016/j.jsps.2018.07.006
   Hussein A.A., 2017, J. Pharmaceut. Sci. Res., V9, P2163
   Ihl R, 2011, INT J GERIATR PSYCH, V26, P1186, DOI 10.1002/gps.2662
   Jaramillo S, 2010, J AGR FOOD CHEM, V58, P10869, DOI 10.1021/jf102669p
   Kandiah N, 2019, CNS NEUROSCI THER, V25, P288, DOI 10.1111/cns.13095
   Kaschel R, 2011, PHYTOMEDICINE, V18, P1202, DOI 10.1016/j.phymed.2011.06.021
   Kaur S, 2018, INFLAMMOPHARMACOLOGY, V26, P87, DOI 10.1007/s10787-017-0396-2
   Kim E, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21186676
   Ku SK, 2013, VASC PHARMACOL, V58, P272, DOI 10.1016/j.vph.2013.01.005
   Kuribara H, 2003, J NAT PROD, V66, P1333, DOI 10.1021/np030122f
   Lasaite L, 2014, NAT PROD COMMUN, V9, P1345
   Li FZ, 2021, CLIN INTERV AGING, V16, P973, DOI 10.2147/CIA.S306431
   Li HX, 2021, MOL NUTR FOOD RES, V65, DOI 10.1002/mnfr.202000746
   Li XX, 2020, CURR VASC PHARMACOL, V18, P334, DOI 10.2174/1570161117666190621150725
   Li YP, 2021, J ETHNOPHARMACOL, V264, DOI 10.1016/j.jep.2020.113279
   Li ZW, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.650278
   Liao ZW, 2020, CLIN NEUROPHARMACOL, V43, P93, DOI 10.1097/WNF.0000000000000394
   Liou CJ, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/298635
   Liu J, 2020, MOL MED REP, V22, P310, DOI 10.3892/mmr.2020.11099
   Liu JL, 2017, RR-2272-BIOG
   Liu YF, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/4598167
   Longpré F, 2006, FREE RADICAL BIO MED, V41, P1781, DOI 10.1016/j.freeradbiomed.2006.08.015
   Lopez OL, 2019, ALZHEIMERS DEMENT, V15, P1029, DOI 10.1016/j.jalz.2019.04.008
   Lu XY, 2018, J PHARMACEUT BIOMED, V160, P46, DOI 10.1016/j.jpba.2018.07.037
   Luo YY, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00692
   Maerz S, 2011, BIOSCIENCE REP, V31, P439, DOI 10.1042/BSR20100128
   Ton AMM, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/2638703
   Matthews Brandy R, 2015, Continuum (Minneap Minn), V21, P613, DOI 10.1212/01.CON.0000466656.59413.29
   McKenna DJ, 2001, ALTERN THER HEALTH M, V7, P70
   Mei N, 2017, J ENVIRON SCI HEAL C, V35, P1, DOI 10.1080/10590501.2016.1278298
   Meng MM, 2019, NEUROREPORT, V30, P434, DOI 10.1097/WNR.0000000000001223
   Milanezi FG, 2019, SAUDI PHARM J, V27, P968, DOI 10.1016/j.jsps.2019.07.005
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Morvaridzadeh M, 2020, CYTOKINE, V135, DOI 10.1016/j.cyto.2020.155224
   Nasab NM, 2012, J PAK MED ASSOC, V62, P677
   Onyango IG, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9050524
   Pan XH, 2020, J FUNCT FOODS, V74, DOI 10.1016/j.jff.2020.104140
   Priyanka A, 2017, INT IMMUNOPHARMACOL, V42, P209, DOI 10.1016/j.intimp.2016.11.019
   Rabilloud T, 2001, PROTEOMICS, V1, P1105, DOI 10.1002/1615-9861(200109)1:9<1105::AID-PROT1105>3.0.CO;2-M
   Ramassamy C, 2006, EUR J PHARMACOL, V545, P51, DOI 10.1016/j.ejphar.2006.06.025
   Raz L, 2016, J CEREBR BLOOD F MET, V36, P172, DOI 10.1038/jcbfm.2015.164
   Rendeiro C, 2012, P NUTR SOC, V71, P246, DOI 10.1017/S0029665112000146
   Rhein V, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012359
   do Rosario VA, 2021, NUTR METAB CARDIOVAS, V31, P950, DOI 10.1016/j.numecd.2020.11.024
   Saini AS, 2014, PHARMACOGN MAG, V10, P172, DOI 10.4103/0973-1296.131031
   Sarkar C, 2020, BIOMED PHARMACOTHER, V132, DOI 10.1016/j.biopha.2020.110908
   Sathya S, 2018, Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases, P239, DOI [DOI 10.1016/B978-0-12-811959-4.00015-8, 10.1016/B978-0-12-811959-4.00015-8]
   Schindowski K, 2001, J NEURAL TRANSM, V108, P969, DOI 10.1007/s007020170016
   Shi C, 2010, PLATELETS, V21, P373, DOI 10.3109/09537100903511448
   Shi C, 2009, CHEM-BIOL INTERACT, V181, P115, DOI 10.1016/j.cbi.2009.05.010
   Shinozuka K, 2002, LIFE SCI, V70, P2783, DOI 10.1016/S0024-3205(02)01530-8
   Shukla R., 2019, Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases, P293, DOI DOI 10.1016/B978-0-12-813820-5.00018-0
   Siegel G, 2014, ATHEROSCLEROSIS, V237, P584, DOI 10.1016/j.atherosclerosis.2014.10.023
   Siegel G, 2011, ATHEROSCLEROSIS, V218, P250, DOI 10.1016/j.atherosclerosis.2011.05.007
   Singh SK, 2019, NEUROTHERAPEUTICS, V16, P666, DOI 10.1007/s13311-019-00767-8
   Smith JV, 2004, APPL MICROBIOL BIOT, V64, P465, DOI 10.1007/s00253-003-1527-9
   Soheili M, 2021, IRAN J BASIC MED SCI, V24, P123, DOI [10.22038/IJBMS.2020.50536.11512, 10.22038/ijbms.2020.50536.11512]
   Hirata BKS, 2015, MEDIAT INFLAMM, V2015, DOI 10.1155/2015/419106
   Stromgaard K, 2004, ANGEW CHEM INT EDIT, V43, P1640, DOI 10.1002/anie.200300601
   Suchal K, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18051001
   Suliman NA, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/4391375
   Tan D, 2019, J TRADIT CHIN MED, V39, P285
   Tanaka S, 2004, YAKUGAKU ZASSHI, V124, P605, DOI 10.1248/yakushi.124.605
   Tao Z, 2019, FOOD FUNCT, V10, P2209, DOI 10.1039/c8fo02506a
   Tarsilla M., 2010, Cochrane Handbook for Systematic Reviews of Interventions version 6.0, V6, P142
   Teng BS, 2006, PHARMACOL RES, V54, P186, DOI 10.1016/j.phrs.2006.04.007
   Tian JF, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/2370617
   Tofano RJ, 2020, DIABET METAB SYND OB, V13, P3239, DOI 10.2147/DMSO.S271050
   Tomino C, 2021, PHARMACEUTICALS-BASE, V14, DOI 10.3390/ph14040305
   Trebatická J, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/248529
   Unger M, 2013, DRUG METAB REV, V45, P353, DOI 10.3109/03602532.2013.815200
   Wang A, 2018, MED SCI MONITOR, V24, P3159, DOI 10.12659/MSM.910718
   Wang CP, 2016, PHYTOTHER RES, V30, P774, DOI 10.1002/ptr.5572
   Wang J, 2021, NEUROCHEM RES, V46, P1881, DOI 10.1007/s11064-021-03315-z
   Wang LP, 2015, GENET MOL RES, V14, P4896, DOI 10.4238/2015.May.11.22
   Wang L, 2013, J ETHNOPHARMACOL, V150, P308, DOI 10.1016/j.jep.2013.08.048
   Wang LX, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/5591573
   Wang X, 2020, BMC COMPLEMENT MED, V20, DOI 10.1186/s12906-020-02980-x
   Weinmann S, 2010, BMC GERIATR, V10, DOI 10.1186/1471-2318-10-14
   Xiang J, 2021, TRANSL PSYCHIAT, V11, DOI 10.1038/s41398-021-01594-2
   Xiao QA, 2010, EUR J PHARMACOL, V647, P48, DOI 10.1016/j.ejphar.2010.08.002
   Yang JH, 2014, TOXICOL APPL PHARM, V274, P293, DOI 10.1016/j.taap.2013.10.026
   Yang MH, 2021, IUBMB LIFE, V73, P1222, DOI 10.1002/iub.2532
   Yang MH, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21218303
   Yao ZX, 2001, BRAIN RES, V889, P181, DOI 10.1016/S0006-8993(00)03131-0
   Yao ZX, 2004, J NUTR BIOCHEM, V15, P749, DOI 10.1016/j.jnutbio.2004.06.008
   Yarmohammadi F, 2021, IRAN J BASIC MED SCI, V24, P420, DOI 10.22038/ijbms.2021.50276.11452
   You OH, 2013, BIOORG MED CHEM LETT, V23, P2692, DOI 10.1016/j.bmcl.2013.02.080
   Zhang Hong, 2018, Zhongguo Zhong Yao Za Zhi, V43, P1410, DOI 10.19540/j.cnki.cjcmm.20180312.005
   Zhang HF, 2016, FRONT AGING NEUROSCI, V8, DOI 10.3389/fnagi.2016.00276
   Zhang R, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.02844
   Zhang R, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00109
   Zhang SJ, 2012, ASIAN PAC J TROP MED, V5, P661, DOI 10.1016/S1995-7645(12)60135-7
   Zhang YQ, 2008, J SURG RES, V148, P17, DOI 10.1016/j.jss.2008.02.036
   Zhao M, 2021, BIOMED RES INT, V2021, DOI 10.1155/2021/8835408
   Zhi Y, 2016, CELL PHYSIOL BIOCHEM, V39, P1787, DOI 10.1159/000447878
   Zhou MJ, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/481405
   Zuin M, 2021, DIAGNOSTICS, V11, DOI 10.3390/diagnostics11060984
   Zuo W, 2017, AGING DIS, V8, P812, DOI 10.14336/AD.2017.0615
NR 145
TC 51
Z9 51
U1 2
U2 28
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAR
PY 2022
VL 11
IS 3
AR 525
DI 10.3390/antiox11030525
PG 27
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 0E8CK
UT WOS:000776902500001
PM 35326176
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Piras, F
   Banaj, N
   Porcari, DE
   Piras, F
   Spalletta, G
AF Piras, Federica
   Banaj, Nerisa
   Porcari, Desiree E.
   Piras, Fabrizio
   Spalletta, Gianfranco
TI Later life depression as risk factor for developing dementia:
   epidemiological evidence, predictive models, preventive strategies and
   future trends
SO MINERVA MEDICA
LA English
DT Review
DE Depressive disorders; Dementia; Risk factors; Prevention and control;
   Early medical intervention
ID MILD COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; NEUROPSYCHIATRIC
   SYMPTOMS; METABOLIC SYNDROME; ASSOCIATION; RESERVE; TRAJECTORIES;
   METAANALYSIS; HIPPOCAMPUS; VOLUME
AB Current investigations in pre-symptomatic dementia have suggested that depressive mood, a treatable condition, may play an important role in the development of the disorder. However, whether depression in adulthood constitute a risk factor, or a prodrome of dementia remains unclear. A major implication in such dispute is the analytic framework used to identify putative risk factors. Indeed, if evaluated in the years immediately prior to dementia diagnosis the association between depression and dementia may reflect depressive symptoms as a prodrome of yet-undiagnosed dementia. Unfortunately, long term prospective cohort investigations, reaching back into the preclinical phase of dementia are sparse. Here, we have surveyed high-quality evidence (systematic reviews and meta-analyses) on the association between depressive symptoms and increased odds of dementia. Meta-analytic findings are also presented and discussed regarding depression as a prodromal stage of dementia, or a consequence of underlying neurodegenerative processes. Additionally, the potential confounding effect of several variables on the risk association between depression and dementia, an aspect hardly investigated, is discussed. While early onset late-life depression - defined as starting before 60 years of age - increases the odds of developing dementia in predisposed subjects, late-onset depression appears to be a prodrome and a clear accelerating factor for cognitive deterioration. Since it is increasingly important to consider the potential of pre-emptive approaches to decrease the impact of dementia, evidence on potentially effective preventive strategies targeting depression as a risk factor, and next steps in further research are presented as concluding remarks.
C1 [Piras, Federica; Banaj, Nerisa; Porcari, Desiree E.; Piras, Fabrizio; Spalletta, Gianfranco] IRCCS Santa Lucia Fdn, Dept Clin & Behav Neurol, Lab Neuropsychiat, Via Ardeatina 306, I-00179 Rome, Italy.
   [Spalletta, Gianfranco] Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA.
C3 IRCCS Santa Lucia; Baylor College of Medicine
RP Spalletta, G (corresponding author), IRCCS Santa Lucia Fdn, Dept Clin & Behav Neurol, Lab Neuropsychiat, Via Ardeatina 306, I-00179 Rome, Italy.
EM g.spalletta@hsantalucia.it
RI Piras, Federica/AAC-4768-2022; Banaj, Nerisa/AAC-3880-2022; piras,
   fabrizio/M-7902-2016
OI piras, fabrizio/0000-0003-3566-5494; Porcari, Desiree
   Estela/0000-0003-4338-1547
FU Italian Ministry of Health [RC18-19-20-21/A]
FX This research was funded by RC18-19-20-21/A grants from the Italian
   Ministry of Health. The authors report no involvement in the research by
   the funder that could have influenced the outcome of this work.
CR Albert MS, 2011, ALZHEIMERS DEMENT, V7, P270, DOI 10.1016/j.jalz.2011.03.008
   Almaguer W, 2002, NEUROBIOL AGING, V23, P319, DOI 10.1016/S0197-4580(01)00278-0
   American Psychiatric Association, 2013, DSM 5
   Anguera JA, 2017, DEPRESS ANXIETY, V34, P508, DOI 10.1002/da.22588
   [Anonymous], 2019, LANCET, V393, P2275, DOI 10.1016/S0140-6736(19)31205-X
   Babulal GM, 2016, AM J GERIAT PSYCHIAT, V24, P1095, DOI 10.1016/j.jagp.2016.04.004
   Barca ML, 2017, J AFFECT DISORDERS, V222, P146, DOI 10.1016/j.jad.2017.07.008
   Burke SL, 2016, INT PSYCHOGERIATR, V28, P1409, DOI 10.1017/S1041610216000405
   Capogna E, 2019, POSTGRAD MED, V131, P533, DOI 10.1080/00325481.2019.1663127
   Carles S, 2020, ALZHEIMERS DEMENT, V16, P1544, DOI 10.1002/alz.12149
   Carroll JC, 2011, J NEUROSCI, V31, P14436, DOI 10.1523/JNEUROSCI.3836-11.2011
   Cherbuin N, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2015-008853
   Cooper C, 2015, AM J PSYCHIAT, V172, P323, DOI 10.1176/appi.ajp.2014.14070878
   Dafsari FS, 2020, TRANSL PSYCHIAT, V10, DOI 10.1038/s41398-020-0839-1
   Darweesh SKL, 2018, ALZHEIMERS DEMENT, V14, P1450, DOI 10.1016/j.jalz.2018.02.014
   Deckers K, 2015, INT J GERIATR PSYCH, V30, P234, DOI 10.1002/gps.4245
   Diniz BS, 2013, BRIT J PSYCHIAT, V202, P329, DOI 10.1192/bjp.bp.112.118307
   Donovan NJ, 2018, AM J PSYCHIAT, V175, P530, DOI 10.1176/appi.ajp.2017.17040442
   Ford E, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194735
   Gracia-García P, 2015, AM J GERIAT PSYCHIAT, V23, P119, DOI 10.1016/j.jagp.2013.02.011
   Hampel H, 2002, J NEUROL SCI, V194, P15, DOI 10.1016/S0022-510X(01)00669-4
   Hasselgren C, 2020, BMC PSYCHIATRY, V20, DOI 10.1186/s12888-020-02820-9
   Hu MY, 2020, J AFFECT DISORDERS, V271, P185, DOI 10.1016/j.jad.2020.03.061
   Huang CM, 2019, SOC COGN AFFECT NEUR, V14, P849, DOI 10.1093/scan/nsz054
   Ismail Z, 2017, JAMA PSYCHIAT, V74, P58, DOI 10.1001/jamapsychiatry.2016.3162
   John A, 2019, PSYCHOL MED, V49, P353, DOI 10.1017/S0033291718001137
   Kaup AR, 2016, JAMA PSYCHIAT, V73, P525, DOI 10.1001/jamapsychiatry.2016.0004
   Kim JM, 2010, PSYCHIAT INVEST, V7, P135, DOI 10.4306/pi.2010.7.2.135
   Kuo CY, 2020, INT J ENV RES PUBLIC, V17, P1
   Kuring JK, 2018, NEUROPSYCHOL REV, V28, P393, DOI 10.1007/s11065-018-9396-2
   Leal SL, 2017, HIPPOCAMPUS, V27, P464, DOI 10.1002/hipo.22705
   Lin CM, 2020, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.00249
   Mirza SS, 2016, LANCET PSYCHIAT, V3, P628, DOI 10.1016/S2215-0366(16)00097-3
   Mourao RJ, 2016, INT J GERIATR PSYCH, V31, P905, DOI 10.1002/gps.4406
   Mulvahill JS, 2017, J AM GERIATR SOC, V65, P2651, DOI 10.1111/jgs.15129
   Ng KP, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.01398
   Norton S, 2014, LANCET NEUROL, V13, P788, DOI 10.1016/S1474-4422(14)70136-X
   Opdebeeck C, 2018, PSYCHOL MED, V48, P61, DOI 10.1017/S003329171700126X
   Opdebeeck C, 2015, REV CLIN GERONTOL, V25, P181, DOI 10.1017/S0959259815000155
   Ownby RL, 2006, ARCH GEN PSYCHIAT, V63, P530, DOI 10.1001/archpsyc.63.5.530
   Peters ME, 2015, AM J GERIAT PSYCHIAT, V23, P115, DOI 10.1016/j.jagp.2014.11.002
   Rodríguez MR, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-181
   Setiawan E, 2018, LANCET PSYCHIAT, V5, P339, DOI 10.1016/S2215-0366(18)30048-8
   Sheline YI, 2010, ARCH GEN PSYCHIAT, V67, P277, DOI 10.1001/archgenpsychiatry.2009.204
   Stern Y, 2002, J INT NEUROPSYCH SOC, V8, P448, DOI 10.1017/S1355617702813248
   Van den Berg MD, 2001, J AFFECT DISORDERS, V65, P19, DOI 10.1016/S0165-0327(00)00263-9
   Vogelzangs N, 2007, PSYCHONEUROENDOCRINO, V32, P151, DOI 10.1016/j.psyneuen.2006.11.009
   Volkert J, 2013, AGEING RES REV, V12, P339, DOI 10.1016/j.arr.2012.09.004
   WELLS CE, 1979, AM J PSYCHIAT, V136, P895
   Wiels W, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00034
NR 50
TC 27
Z9 28
U1 1
U2 5
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0026-4806
EI 1827-1669
J9 MINERVA MED
JI Minerva Med.
PD AUG
PY 2021
VL 112
IS 4
BP 456
EP 466
DI 10.23736/S0026-4806.21.07571-6
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA TK7MU
UT WOS:000674340400005
PM 34056888
DA 2025-06-11
ER

PT J
AU Marín-Echeverri, C
   Blesso, CN
   Fernández, ML
   Galvis-Pérez, Y
   Ciro-Gómez, G
   Núñez-Rangel, V
   Aristizábal, JC
   Barona-Acevedo, J
AF Marin-Echeverri, Catalina
   Blesso, Christopher N.
   Fernandez, Maria Luz
   Galvis-Perez, Yeisson
   Ciro-Gomez, Gelmy
   Nunez-Rangel, Vitelbina
   Aristizabal, Juan C.
   Barona-Acevedo, Jacqueline
TI Effect of Agraz (Vaccinium meridionale Swartz) on High-Density
   Lipoprotein Function and Inflammation in Women with Metabolic Syndrome
SO ANTIOXIDANTS
LA English
DT Article
DE Andean berry; cardiovascular risk factors; HDL dysfunction;
   inflammation; oxidative stress
ID APOLIPOPROTEIN-A-I; NF-KAPPA-B; CHOLESTEROL EFFLUX CAPACITY; PARAOXONASE
   1 ACTIVITY; ANTIOXIDANT ACTIVITY; OXIDATIVE STRESS; HDL; ANTHOCYANINS;
   MYELOPEROXIDASE; EXTRACT
AB Metabolic syndrome (MetS) is associated with low-grade inflammation and high-density lipoprotein (HDL) dysfunction. Polyphenol-rich foods may improve these alterations. Agraz is a fruit rich in polyphenols (mainly anthocyanins); however, there is limited information about its effects on human health. We evaluated the effects of agraz consumption as compared to placebo on HDL function and inflammation in women with MetS. Forty volunteers (25-60 years) were included in this double-blind crossover study. Women consumed agraz or placebo over 4 weeks; separated by a 4-week washout period. HDL function (apoliprotein-A1; paraoxonase 1 (PON1) activity; cholesterol efflux capacity), oxidative stress (myeloperoxidase (MPO), advanced oxidation protein products) and inflammatory markers (serum cytokines/chemokines and peripheral blood mononuclear cell nuclear factor-kB) were measured after each period. Compared to placebo, agraz consumption did not significantly change any of the biomarkers measured. Interestingly, only after agraz period there were significant positive correlations between PON1 activities and cholesterol efflux. Additionally, there were significant inverse correlations between changes in inflammatory markers and HDL function markers and positive correlations with oxidative markers. Although polyphenol-rich foods have been shown to be beneficial for certain conditions; polyphenol-rich agraz fruit consumption did not impact inflammation and HDL function in the current study of women with MetS.
C1 [Marin-Echeverri, Catalina; Galvis-Perez, Yeisson; Ciro-Gomez, Gelmy; Nunez-Rangel, Vitelbina; Barona-Acevedo, Jacqueline] Univ Antioquia UdeA, Sch Microbiol, Ophidism Program, Food & Therapeut Alternat Area, Calle 70 52-21, Medellin 050010, Colombia.
   [Blesso, Christopher N.; Fernandez, Maria Luz] Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
   [Aristizabal, Juan C.] Univ Antioquia UdeA, Sch Nutr & Dietet, Res Grp Physiol & Biochem PHYSIS, Calle 70 52-21, Medellin 050010, Colombia.
C3 Universidad de Antioquia; University of Connecticut; Universidad de
   Antioquia
RP Barona-Acevedo, J (corresponding author), Univ Antioquia UdeA, Sch Microbiol, Ophidism Program, Food & Therapeut Alternat Area, Calle 70 52-21, Medellin 050010, Colombia.
EM catalina.marin@udea.edu.co; christopher.blesso@uconn.edu;
   maria-luz.fernandez@uconn.edu; yeisson.galvis@udea.edu.co;
   gelmy.ciro@udea.edu.co; vitelbina.nunez@udea.edu.co;
   juan.aristizabal@udea.edu.co; maria.barona@udea.edu.co
RI Acevedo, Maria/A-8759-2019; Rivera, Juan/B-6591-2014; Blesso,
   Christopher/N-9495-2014
OI Barona Acevedo, Maria Jacqueline/0000-0002-0592-9324; Blesso,
   Christopher/0000-0002-4434-4839; Aristizabal, Juan/0000-0001-5781-5903;
   Marin Echeverri, Catalina/0000-0002-4267-5677; Ciro Gomez, Gelmy
   Luz/0000-0003-2559-4776; Fernandez, Maria-Luz/0000-0002-1835-0792;
   Galvis Perez, Yeisson/0000-0002-3600-2580
FU Departamento Administrativo de Ciencia, Tecnologia e
   Innovacion-Colciencias [111565740563, 657-2014, FP44842-124-2017];
   University of Antioquia UdeA, Medellin-Colombia
FX This study was supported by Departamento Administrativo de Ciencia,
   Tecnologia e Innovacion-Colciencias through two different grants:
   111565740563, Contract No. 657-2014 and FP44842-124-2017; and the
   University of Antioquia UdeA, Medellin-Colombia.
CR Aharoni S, 2013, ATHEROSCLEROSIS, V228, P353, DOI 10.1016/j.atherosclerosis.2013.03.005
   Annema W, 2016, SCI REP-UK, V6, DOI 10.1038/srep27367
   Barona J, 2012, J NUTR, V142, P1626, DOI 10.3945/jn.112.162743
   Barter PJ, 2007, NEW ENGL J MED, V357, P2109, DOI 10.1056/NEJMoa0706628
   Bergt C, 2004, P NATL ACAD SCI USA, V101, P13032, DOI 10.1073/pnas.0405292101
   Boden WE, 2011, NEW ENGL J MED, V365, P2255, DOI 10.1056/NEJMoa1107579
   Capeillère-Blandin C, 2004, BBA-MOL BASIS DIS, V1689, P91, DOI 10.1016/j.bbadis.2004.02.008
   Simao TNC, 2013, BRIT J NUTR, V110, P1885, DOI 10.1017/S0007114513001207
   Corsetti JP, 2010, EUR J CLIN INVEST, V40, P483, DOI 10.1111/j.1365-2362.2010.02287.x
   de Souza JA, 2008, ATHEROSCLEROSIS, V197, P84, DOI 10.1016/j.atherosclerosis.2007.08.009
   Du CY, 2015, DRUG DES DEV THER, V9, DOI 10.2147/DDDT.S90201
   Espinosa-Moncada J, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111639
   Farrell N, 2015, FOOD FUNCT, V6, P1278, DOI [10.1039/c4fo01036a, 10.1039/C4FO01036A]
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   FRIEDEWALD WT, 1972, CLIN CHEM, V18
   Garzón GA, 2010, FOOD CHEM, V122, P980, DOI 10.1016/j.foodchem.2010.03.017
   GORDON T, 1977, AM J MED, V62, P707, DOI 10.1016/0002-9343(77)90874-9
   Gouédard C, 2004, MOL CELL BIOL, V24, P5209, DOI 10.1128/MCB.24.12.5209-5222.2004
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Gryszczynska B, 2017, BIOMED RES INT, V2017, DOI 10.1155/2017/4975264
   Han CY, 2006, ARTERIOSCL THROM VAS, V26, P1806, DOI 10.1161/01.ATV.0000227472.70734.ad
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Haraguchi Y, 2014, ATHEROSCLEROSIS, V234, P288, DOI 10.1016/j.atherosclerosis.2014.03.009
   Hazen SL, 1997, J CLIN INVEST, V99, P2075, DOI 10.1172/JCI119379
   Hine D, 2012, IUBMB LIFE, V64, P157, DOI 10.1002/iub.588
   Hyka N, 2001, BLOOD, V97, P2381, DOI 10.1182/blood.V97.8.2381
   Ibero-Baraibar I, 2014, NUTR METAB CARDIOVAS, V24, P416, DOI 10.1016/j.numecd.2013.09.017
   Jeong JW, 2013, INT J MOL SCI, V14, P1502, DOI 10.3390/ijms14011502
   Karlsen A, 2007, J NUTR, V137, P1951
   Karlsen A, 2010, EUR J NUTR, V49, P345, DOI 10.1007/s00394-010-0092-0
   Khateeb J, 2010, ATHEROSCLEROSIS, V208, P119, DOI 10.1016/j.atherosclerosis.2009.08.051
   Khera AV, 2011, NEW ENGL J MED, V364, P127, DOI 10.1056/NEJMoa1001689
   Kim SH, 2011, SCAND J CLIN LAB INV, V71, P1, DOI 10.3109/00365513.2010.519047
   Kontush A, 2010, CURR OPIN LIPIDOL, V21, P312, DOI 10.1097/MOL.0b013e32833bcdc1
   Lee SG, 2014, J NUTR BIOCHEM, V25, P404, DOI 10.1016/j.jnutbio.2013.12.001
   Lopera YE, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/516727
   Lu NH, 2018, J AGR FOOD CHEM, V66, P4933, DOI 10.1021/acs.jafc.8b01537
   MACKNESS MI, 1991, FEBS LETT, V286, P152, DOI 10.1016/0014-5793(91)80962-3
   Millar CL, 2018, METAB SYNDR RELAT D, V16, P464, DOI 10.1089/met.2018.0052
   Mohammadi M, 2017, REP BIOCHEM MOL BIOL, V6, P74
   Alvarez JMM, 2011, NUTR HOSP, V26, P1333, DOI [10.3305/nh.2011.26.6.5267, 10.1590/S0212-16112011000600021]
   Mukhamedova N, 2008, J LIPID RES, V49, P2312, DOI 10.1194/jlr.M800095-JLR200
   Nemzer BV, 2011, NUTR J, V10, DOI 10.1186/1475-2891-10-67
   Qin Y, 2009, AM J CLIN NUTR, V90, P485, DOI 10.3945/ajcn.2009.27814
   Rock W, 2008, J AGR FOOD CHEM, V56, P8704, DOI 10.1021/jf801756x
   Rosenblat M, 2005, ATHEROSCLEROSIS, V179, P69, DOI 10.1016/j.atherosclerosis.2004.10.028
   Rosenblat M, 2010, FOOD FUNCT, V1, P99, DOI 10.1039/c0fo00011f
   Shiba Y, 2008, CHEM RES TOXICOL, V21, P1600, DOI 10.1021/tx8000835
   Shin MJ, 2009, CLIN CHIM ACTA, V405, P139, DOI 10.1016/j.cca.2009.04.020
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   van der Steeg WA, 2008, J AM COLL CARDIOL, V51, P634, DOI 10.1016/j.jacc.2007.09.060
   VanLenten BJ, 1995, J CLIN INVEST, V96, P2758, DOI 10.1172/JCI118345
   Velarde GP, 2015, AM J CARDIOL, V116, P1705, DOI 10.1016/j.amjcard.2015.09.010
   Venturini D, 2015, NUTR RES, V35, P759, DOI 10.1016/j.nutres.2015.06.013
   World Health Organization, DIS BURD MORT EST CA
   Yilmaz H, 2010, KARDIOL POL, V68, P1219
   Zheng L, 2005, J BIOL CHEM, V280, P38, DOI 10.1074/jbc.M407019200
   Zhu YN, 2014, J CLIN ENDOCR METAB, V99, P561, DOI 10.1210/jc.2013-2845
NR 58
TC 17
Z9 17
U1 0
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD DEC
PY 2018
VL 7
IS 12
AR 185
DI 10.3390/antiox7120185
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA HG1JF
UT WOS:000454709200016
PM 30544803
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Leu, HB
   Lin, CP
   Lin, WT
   Wu, TC
   Lin, SJ
   Chen, JW
AF Leu, HB
   Lin, CP
   Lin, WT
   Wu, TC
   Lin, SJ
   Chen, JW
TI Circulating mononuclear superoxide production and inflammatory markers
   for long-term prognosis in patients with cardiac syndrome X
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE cardiac syndrome X; mononuclear cell; prognosis; soluble vascular cell
   adhesion molecule-1; superoxide; free radicals
ID NORMAL CORONARY ANGIOGRAMS; C-REACTIVE PROTEIN; LEFT-VENTRICULAR
   FUNCTION; CHEST-PAIN; OXIDATIVE-STRESS; CLINICAL CHARACTERISTICS;
   MYOCARDIAL-ISCHEMIA; ANGINA-PECTORIS; ARTERY-DISEASE; OXIDANT STRESS
AB Increased oxidative stress and vascular inflammation have been shown in patients with cardiac syndrome X (CSX: angina, exercise-induced ischemia, and normal coronary angiogram). This study was conducted to assess the impact of basal superoxide generation by circulating mononuclear cells (MNCs), a contributor to intravascular oxidative stress, and serum inflammatory biomarkers, including high-sensitivity C-reactive protein, homocysteine, soluble intercellular adhesion molecule-1, soluble vascular adhesion molecule-1, and von Willebrand factor, on the long-term prognosis of CSX. During a mean follow-up of 31.5 +/- 14.2 months (maximum 5 years), a total of 12 events were recorded in 92 consecutive CSX patients. There were no deaths or myocardial infarctions, but 8 hospitalizations for acute coronary syndrome, 3 for stroke, and 1 for congestive heart failure due to left ventricular systolic dysfunction. Under univariate analysis, only basal superoxide generation by MNCs was associated with the risk for cardiovascular event. Based on multivariate analysis, basal superoxide generation by MNCs could still independently predict future events (relative risk for the highest compared to the lowest tertile, 3.87, 95% confidence interval, 1.42-10.54, p = 0.008). These findings demonstrate that long-term prognosis is fair in patients with CSX. Basal superoxide production of MNCs independently predicts future cardiovascular events, suggesting its potential role in measuring disease progression and risk stratification in these patients. (C) 2005 Elsevier Inc. All rights reserved.
C1 Natl Yang Ming Univ, Sch Med, Cardiovasc Res Ctr, Taipei 112, Taiwan.
   Natl Yang Ming Univ, Sch Med, Inst Clin Med, Taipei 112, Taiwan.
   Taipei Vet Gen Hosp, Dept Med, Div Cardiol, Taipei, Taiwan.
   Taipei Vet Gen Hosp, Dept Pathol, Taipei, Taiwan.
C3 National Yang Ming Chiao Tung University; National Yang Ming Chiao Tung
   University; Taipei Veterans General Hospital; Taipei Veterans General
   Hospital
RP Natl Yang Ming Univ, Sch Med, Cardiovasc Res Ctr, Taipei 112, Taiwan.
EM jwchen@vghtpe.gov.tw
CR AMAL JF, 1999, CELL MOL LIFE SCI, V55, P1078
   Arroyo-Espliguero R, 2003, EUR HEART J, V24, P2006, DOI 10.1016/j.ehj.2003.09.029
   Bae JH, 2001, ATHEROSCLEROSIS, V155, P517, DOI 10.1016/S0021-9150(00)00601-8
   Bowie A, 2000, BIOCHEM PHARMACOL, V59, P13, DOI 10.1016/S0006-2952(99)00296-8
   Brennan ML, 2003, CURR OPIN LIPIDOL, V14, P353, DOI 10.1097/00041433-200308000-00003
   Buffon A, 2000, AM J PHYSIOL-HEART C, V279, pH2627, DOI 10.1152/ajpheart.2000.279.6.H2627
   CHAUHAN A, 1994, CIRCULATION, V89, P1998, DOI 10.1161/01.CIR.89.5.1998
   Chauhan A, 1997, EUR HEART J, V18, P60
   CHAUHAN A, 1994, J AM COLL CARDIOL, V24, P329, DOI 10.1016/0735-1097(94)90284-4
   Chen JW, 2000, INT J CARDIOL, V75, P49, DOI 10.1016/S0167-5273(00)00285-0
   Chen JW, 2002, AM J CARDIOL, V90, P974, DOI 10.1016/S0002-9149(02)02664-4
   Chen JW, 1996, JPN HEART J, V37, P865
   Cooper Dianne, 2002, Cardiovasc Toxicol, V2, P165, DOI 10.1007/s12012-002-0002-7
   Cosín-Sales J, 2003, J AM COLL CARDIOL, V41, P1468, DOI 10.1016/S0735-1097(03)00243-2
   Diaz MN, 1997, NEW ENGL J MED, V337, P408, DOI 10.1056/NEJM199708073370607
   EGASHIRA K, 1993, NEW ENGL J MED, V328, P1659, DOI 10.1056/NEJM199306103282302
   Foussas SG, 1998, ANGIOLOGY, V49, P349, DOI 10.1177/000331979804900503
   FROBERT O, 1995, EUR HEART J, V16, P1356, DOI 10.1093/oxfordjournals.eurheartj.a060742
   Griendling KK, 2000, ARTERIOSCL THROM VAS, V20, P2175, DOI 10.1161/01.ATV.20.10.2175
   Gulli G, 2001, CARDIOVASC RES, V52, P208, DOI 10.1016/S0008-6363(01)00369-8
   Ho KJ, 2000, ANN RHEUM DIS, V59, P338, DOI 10.1136/ard.59.5.338
   Hofmann MA, 1999, DIABETOLOGIA, V42, P222, DOI 10.1007/s001250051142
   Janiszewski M, 2002, FREE RADICAL BIO MED, V32, P446, DOI 10.1016/S0891-5849(01)00828-0
   Jialal I, 2001, J NUTR, V131, p389S, DOI 10.1093/jn/131.2.389S
   KASKI JC, 1995, J AM COLL CARDIOL, V25, P807, DOI 10.1016/0735-1097(94)00507-M
   Kaski Juan Carlos, 2004, Am J Cardiovasc Drugs, V4, P179, DOI 10.2165/00129784-200404030-00005
   KEMP HG, 1973, AM J CARDIOL, V32, P375, DOI 10.1016/S0002-9149(73)80150-X
   Lang D, 2000, CIRC RES, V86, P463, DOI 10.1161/01.RES.86.4.463
   Lanza GA, 2001, EUR HEART J, V22, P1924, DOI 10.1053/euhj.2001.2624
   Lee WL, 1998, INT J CARDIOL, V66, P253
   Leeuwenburgh C, 1997, J BIOL CHEM, V272, P3520, DOI 10.1074/jbc.272.6.3520
   Leu HB, 2004, CHEST, V126, P1032, DOI 10.1378/chest.126.4.1032
   LICHTLEN PR, 1995, J AM COLL CARDIOL, V25, P1013, DOI 10.1016/0735-1097(94)00519-V
   Lin CP, 2003, INT J CARDIOL, V89, P53, DOI 10.1016/S0167-5273(02)00428-X
   Miatello R, 2002, AM J HYPERTENS, V15, P872, DOI 10.1016/S0895-7061(02)02983-7
   Nakamura R, 2002, CIRCULATION, V106, P362, DOI 10.1161/01.CIR.0000021430.04195.51
   Pizzi C, 2004, CIRCULATION, V109, P53, DOI 10.1161/01.CIR.0000100722.34034.E4
   Ridker PM, 2000, NEW ENGL J MED, V342, P836, DOI 10.1056/NEJM200003233421202
   Thusu K, 1998, Methods Mol Biol, V108, P57
   Tousoulis D, 2001, CLIN CARDIOL, V24, P301, DOI 10.1002/clc.4960240409
   WANG HD, 1998, CIRC RES, V20, P810
NR 41
TC 27
Z9 28
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD MAR 15
PY 2006
VL 40
IS 6
BP 983
EP 991
DI 10.1016/j.freeradbiomed.2005.10.047
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 027GX
UT WOS:000236404100009
PM 16540394
DA 2025-06-11
ER

PT J
AU Bjelanovic, V
   Babic, D
   Oreskovic, S
   Tomic, V
   Martinac, M
   Juras, J
AF Bjelanovic, Vedran
   Babic, Dragan
   Oreskovic, Slavko
   Tomic, Vajdana
   Martinac, Marko
   Juras, Josip
TI Pathological Pregnancy and Psychological Symptoms in Women
SO COLLEGIUM ANTROPOLOGICUM
LA English
DT Article
DE pathology and normal pregnancy; psychological symptoms; metabolic
   syndrome
ID HYPERTENSION; DEPRESSION; ANXIETY
AB Pregnancy is followed by many physiologic, organic and psychological changes and disorders, which can become more serious in pregnancy followed by complications, especially in women with pathological conditions during pregnancy. The purpose of this study was to find out and analyze the prevalence and intensity of psychological disorders in women with pathological conditions during pregnancy and compare it with conditions in pregnant women who had normal development of pregnancy. The research is approved by the Ethical committee of the Mostar University Hospital Center, and it was made in accordance with Helsinki declaration and good clinical practices. The research conducted section for pathology of pregnancy of Department for gynecology and obstetrics of the Mostar University Hospital Center It included 82 pregnant women with disorders in pregnancy developement and control group consisted of pregnant women who had normal development of pregnancy. The research work was conducted from September 2007 to August 2008 in Mostar University Hospital Center. Pregnant women had Standard and laboratory tests, Ultrasound. CTG examinations were done for all pregnant women and additional tests for those women with complications during pregnancy. Pregnant women completed sociobiographical, obstetrical-clinical and psychological SCL 90-R questionnaire. Pregnant women with pathological pregnancy exibited significantly more psychological symptoms in comparison to pregnant women with normal pregnancy (p<0.001 to p=0.004). Frequency and intensity of psychical symptoms and disorders statisticly are more characteristic in pathological pregnancy (61%/40.6%). The statistical data indicate a significantly higher score of psychological disorders in those pregnant women with primary school education (p=0.050), those who take more than 60% carbohydrates (p=0.001), those with pathological CTG records (p<0.001), those with pathological ultrasound results (p<0.001 to 0.216) and those pregnant women with medium obesity and obesity (p=0.046). Body mass index (BMI) during normal pregnancy development is lower (p=0.002) but the levels of glucose, triglycerides, cholesterol, HDL and LDL in blood are higher. Blood pressure in pregnant women with pathological pregnancy was statistically significantly higher (p<0.001). Diagnostic criteria for the metabolic syndrome were found in 19 pregnant women with the pathological pregnancy. Statistically, in those women, a significantly higher appearance of psychological symptoms and disorders was observed in comparison to the pregnant women without metabolic syndrome (p<0.001). The research has shown that 87.8% from all pregnant women included in this study have been hospitalized due to premature birth, hypertensive disorders, and diabetes in pregnancy, and also due to bleeding in the second and third trimester of pregnancy.
C1 [Bjelanovic, Vedran; Oreskovic, Slavko; Tomic, Vajdana] Mostar Univ, Ctr Hosp, Dept Gynecol & Obstet, Mostar 88000, Bosnia & Herceg.
   [Babic, Dragan; Martinac, Marko] Mostar Univ, Ctr Hosp, Dept Psychiat, Mostar 88000, Bosnia & Herceg.
   [Oreskovic, Slavko; Juras, Josip] Univ Zagreb, Ctr Hosp, Dept Gynecol & Obstet, Zagreb 41000, Croatia.
C3 University of Mostar; University of Mostar; University of Zagreb
RP Bjelanovic, V (corresponding author), Mostar Univ, Ctr Hosp, Dept Gynecol & Obstet, Mostar 88000, Bosnia & Herceg.
EM vedranbjelanovic@yahoo.com
OI Juras, Josip/0000-0002-1801-5732; Martinac, Marko/0000-0001-9144-6427
CR Anderson R, 2000, NAT HIST, V109, P23
   Andersson L, 2004, OBSTET GYNECOL, V104, P467, DOI 10.1097/01.AOG.0000135277.04565.e9
   Babic D, 2007, PSYCHIAT DANUB, V19, P68
   Börjesson K, 2005, ARCH WOMEN MENT HLTH, V8, P232, DOI 10.1007/s00737-005-0086-8
   BORJESSON K, 2006, MIDWIFERY
   Brown MA, 2000, AUST NZ J OBSTET GYN, V40, P139, DOI 10.1111/j.1479-828X.2000.tb01137.x
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Davidson K, 2000, ARCH INTERN MED, V160, P1495, DOI 10.1001/archinte.160.10.1495
   DEROGATIS LR, 1977, THE SYMPTOM CHECKLIS
   Djelmis J, 2001, J PERINAT MED, V29, P241, DOI 10.1515/JPM.2001.034
   Goffinet F, 2001, EUR J OBSTET GYN R B, V94, P59, DOI 10.1016/S0301-2115(00)00317-1
   Klaric M, 2007, CROAT MED J, V48, P167
   Kurjak A, 2005, CROAT MED J, V46, P772
   Kuvacic I, 2003, PERINATOLOGIJA DANAS
   Mancuso RA, 2004, PSYCHOSOM MED, V66, P762, DOI 10.1097/01.psy.0000138284.70670.d5
   MARTINAC M, 2007, SOC PSIHIJTRIJA, V1, P13
   Metelko Z, 2000, Lijec Vjesn, V122, P99
   PICKETT KE, 2000, PEDIATR PERINATAL EP, V14, P305, DOI [10.1046/j.1365-3016.2000.00293.x, DOI 10.1046/J.1365-3016.2000.00293.X]
   Santvana S, 2005, J OBSTET GYN INDIA, V55, P218
   SCOTT JR, 1997, DANFORTHS OBSTETRICS
   Vulink NCC, 2006, INT CLIN PSYCHOPHARM, V21, P171, DOI 10.1097/01.yic.0000199454.62423.99
   Wallenburg HCS, 2001, EUR J OBSTET GYN R B, V94, P13, DOI 10.1016/S0301-2115(00)00303-1
   Yamasue H, 2005, NEUROLOGY, V65, P491, DOI 10.1212/01.wnl.0000172360.99310.3f
   ZULCIC-NAKIC V, 2000, NEUROL CROATICA, V49, P69
NR 24
TC 5
Z9 5
U1 0
U2 13
PU COLLEGIUM ANTROPOLOGICUM
PI ZAGREB
PA INST ANTHROPOLOGICAL RESEARCH, GAJEVA 32, PO BOX 290, HR-10000 ZAGREB,
   CROATIA
SN 0350-6134
J9 COLLEGIUM ANTROPOL
JI Coll. Anthropol.
PD SEP
PY 2012
VL 36
IS 3
BP 847
EP 852
PG 6
WC Anthropology
WE Social Science Citation Index (SSCI)
SC Anthropology
GA 031TB
UT WOS:000310664100020
PM 23213943
DA 2025-06-11
ER

PT J
AU Fraga, MC
   Moura, EG
   Silva, JO
   Bonomo, IT
   Filgueiras, CC
   Abreu-Villaça, Y
   Passos, MCF
   Lisboa, PC
   Manhaes, AC
AF Fraga, Mabel C.
   Moura, Egberto G.
   Silva, Juliana Oliveira
   Bonomo, Isabela Teixeira
   Filgueiras, Claudio C.
   Abreu-Villaca, Yael
   Passos, Magna C. F.
   Lisboa, Patricia C.
   Manhaes, Alex C.
TI Maternal prolactin inhibition at the end of lactation affects
   learning/memory and anxiety-like behaviors but not novelty-seeking in
   adult rat progeny
SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
LA English
DT Article
DE Hypoprolactinemia; Early weaning; Developmental plasticity; Behavior;
   Rats
ID ADOLESCENT C57BL/6 MICE; THYROID-HORMONE ACTION; ELEVATED PLUS-MAZE;
   PRENATAL STRESS; METABOLIC SYNDROME; FEMALE RATS; CENTRAL
   HYPOTHYROIDISM; DEVELOPMENTAL ORIGINS; HIPPOCAMPAL-FORMATION;
   EXPLORATORY-BEHAVIOR
AB Maternal hypoprolactinemia at the end of lactation in rats reduces milk production and is associated with offspring's malnutrition. Since malnutrition during development is also known to have long lasting effects on cognition and emotion, in the present study we tested the hypothesis that maternal hypoprolactinemia, induced by bromocriptine treatment, at the end of the lactating period affects memory/learning, novelty-seeking and anxiety-like behaviors in adult male Wistar rats using, respectively, the radial arm water maze (RAWM), the hole board (HB) arena and the elevated plus-maze (EPNl). We also analyzed serum corticosterone and thyroid hormone levels at postnatal day (PN) 21. Lactating dams were treated with bromocriptine (BRO, 1 mg twice a day, inhibiting prolactin) or saline from PN19 to 21 (the last 3 days of lactation). BRO offspring had hypercorticosteronemia and hypothyroidism at PN21. In the RAWM, reductions in latency observed in CON rats were initially more accentuated than in BRO ones. By the end of the testing period, latencies became similar between groups. No difference was observed between groups regarding the number of nose-pokes in the HB. In the EPM, BRO rats stayed less time in and had fewer entries into the open-arms than CON ones. This pattern of results indicates that maternal bromocriptine treatment at the end of the lactating period results in poorer memory/learning performance and in higher levels of anxiety-like behavior in the adult offspring, demonstrating that even a relatively short period of malnutrition during development can have long lasting detrimental effects regarding cognition and emotion. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Fraga, Mabel C.; Silva, Juliana Oliveira; Filgueiras, Claudio C.; Abreu-Villaca, Yael; Manhaes, Alex C.] Univ Estado Rio de Janeiro, Lab Neurofisiol, Dept Ciencias Fisiol, Inst Biol Roberto Alcantara Gomes,Ctr Biomed, BR-20550170 Rio De Janeiro, Brazil.
   [Fraga, Mabel C.; Moura, Egberto G.; Silva, Juliana Oliveira; Bonomo, Isabela Teixeira; Passos, Magna C. F.; Lisboa, Patricia C.] Univ Estado Rio de Janeiro, Lab Fisiol Endocrina, Dept Ciencias Fisiol, Inst Biol Roberto Alcantara Gomes,Ctr Biomed, BR-20550170 Rio De Janeiro, Brazil.
C3 Universidade do Estado do Rio de Janeiro; Universidade do Estado do Rio
   de Janeiro
RP Manhaes, AC (corresponding author), Univ Estado Rio de Janeiro, Lab Neurofisiol, Dept Ciencias Fisiol, Inst Biol Roberto Alcantara Gomes,Ctr Biomed, Av Prof Manuel de Abreu 444,5 Andar, BR-20550170 Rio De Janeiro, Brazil.
EM amanhaes@uerj.br
RI Manhães, Alex/F-5499-2011; Abreu-Villaca, Yael/D-5997-2015; Filgueiras,
   Claudio/MBG-9894-2025; Moura, Egberto/H-1270-2012; Lisboa,
   Patricia/H-8336-2015
OI Filgueiras, Claudio/0000-0003-4522-4799; Moura,
   Egberto/0000-0002-1159-7549; Lisboa, Patricia/0000-0002-2477-4364;
   Abreu-Villaca, Yael/0000-0002-9801-6179; Manhaes, Alex
   C./0000-0003-4629-8343
FU Fundacao Carlos Chagas Filho de Amparo Pesquisa do Estado do Rio de
   Janeiro (FAPERJ); Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq); Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior (CAPES); Sub-Reitoria de Pos-graduacao e Pesquisa da
   Universidade do Estado do Rio de Janeiro (SR2-UERJ)
FX Funding for this study was provided by Fundacao Carlos Chagas Filho de
   Amparo Pesquisa do Estado do Rio de Janeiro (FAPERJ), Conselho Nacional
   de Desenvolvimento Cientifico e Tecnologico (CNPq), Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES) and by Sub-Reitoria
   de Pos-graduacao e Pesquisa da Universidade do Estado do Rio de Janeiro
   (SR2-UERJ). MCF and ITB are recipients of FAPERJ postdoctoral
   fellowships, while JOS is recipient of CNPq fellowship for undergraduate
   students. The authors are thankful to Ulisses Risso Siqueira for the
   animal care.
CR Abreu-Villaça Y, 2006, BEHAV BRAIN RES, V167, P175, DOI 10.1016/j.bbr.2005.09.003
   Ahima RS, 1996, NATURE, V382, P250, DOI 10.1038/382250a0
   Anderson GW, 2001, FRONT NEUROENDOCRIN, V22, P1, DOI 10.1006/frne.2000.0208
   Andrade JP, 1996, EXP BRAIN RES, V109, P419
   [Anonymous], 1976, Journal of Educational Statistics, DOI [DOI 10.3102/10769986001001069, 10.3102/10769986001001069]
   Armitage JA, 2008, FRONT HORM RES, V36, P73, DOI 10.1159/000115355
   Bannerman DM, 2004, NEUROSCI BIOBEHAV R, V28, P273, DOI 10.1016/j.neubiorev.2004.03.004
   Barker DJP, 2003, EUR J EPIDEMIOL, V18, P733, DOI 10.1023/A:1025388901248
   Bast T, 2003, PROG NEUROBIOL, V70, P319, DOI 10.1016/S0301-0082(03)00112-6
   Bernal J, 2002, J ENDOCRINOL INVEST, V25, P268, DOI 10.1007/BF03344003
   Bhatnagar S, 2005, HORM BEHAV, V47, P430, DOI 10.1016/j.yhbeh.2004.11.019
   Bonomo IT, 2008, J ENDOCRINOL, V198, P331, DOI 10.1677/JOE-07-0505
   Bonomo IT, 2007, J ENDOCRINOL, V192, P339, DOI 10.1677/joe.1.06952
   Bonomo IT, 2005, HORM METAB RES, V37, P220, DOI 10.1055/s-2005-861381
   Bouret SG, 2004, SCIENCE, V304, P108, DOI 10.1126/science.1095004
   Brunson KL, 2001, MOL PSYCHIATR, V6, P647, DOI 10.1038/sj.mp.4000942
   Bunsey M, 1996, NATURE, V379, P255, DOI 10.1038/379255a0
   Bunsey M, 1995, HIPPOCAMPUS, V5, P546, DOI 10.1002/hipo.450050606
   Carola V, 2002, BEHAV BRAIN RES, V134, P49, DOI 10.1016/S0166-4328(01)00452-1
   CHANOINE JP, 1993, J CLIN INVEST, V91, P2709, DOI 10.1172/JCI116510
   Charney D.S., 1999, Neurobiology of mental illness, P494
   Ciaroni S, 2002, NEUROSCI RES, V44, P369, DOI 10.1016/S0168-0102(02)00157-8
   CoupE B, 2009, J NEUROENDOCRINOL, V21, P40, DOI 10.1111/j.1365-2826.2008.01806.x
   Darnaudéry M, 2008, BRAIN RES REV, V57, P571, DOI 10.1016/j.brainresrev.2007.11.004
   de Moura EG, 2008, NEUROIMMUNOMODULAT, V15, P176, DOI 10.1159/000153422
   de Moura EG, 2009, J PHYSIOL-LONDON, V587, P4919, DOI 10.1113/jphysiol.2009.176289
   DOBBING J, 1964, PROC R SOC SER B-BIO, V159, P503, DOI 10.1098/rspb.1964.0016
   DRAGO F, 1990, PSYCHONEUROENDOCRINO, V15, P349, DOI 10.1016/0306-4530(90)90060-M
   DUSSAULT JH, 1987, ANNU REV PHYSIOL, V49, P321, DOI 10.1146/annurev.ph.49.030187.001541
   EAYRS J. T., 1964, ARCH BIOL, V75, P529
   Farr SA, 2008, ENDOCRINOLOGY, V149, P2628, DOI 10.1210/en.2007-1722
   FISCHBECK KL, 1987, J NUTR, V117, P1967, DOI 10.1093/jn/117.11.1967
   Fraga-Marques MC, 2010, BEHAV BRAIN RES, V206, P147, DOI 10.1016/j.bbr.2009.08.029
   Fraga-Marques MC, 2009, HORM BEHAV, V55, P272, DOI 10.1016/j.yhbeh.2008.11.010
   Frye CA, 2004, PHARMACOL BIOCHEM BE, V78, P531, DOI 10.1016/j.pbb.2004.03.024
   FUNDARO A, 1989, PROG NEURO-PSYCHOPH, V13, P927, DOI 10.1016/0278-5846(89)90044-4
   Galtry J, 1997, Health Care Women Int, V18, P467
   Gluckman PD, 2007, J INTERN MED, V261, P461, DOI 10.1111/j.1365-2796.2007.01802.x
   GOMENDIO M, 1995, BEHAV ECOL SOCIOBIOL, V37, P71, DOI 10.1007/s0026550370071
   Guadaño-Ferraz A, 2003, MOL PSYCHIATR, V8, P30, DOI 10.1038/sj.mp.4001196
   HANDLEY SL, 1993, J PHARMACOL TOX MET, V29, P129, DOI 10.1016/1056-8719(93)90063-K
   Harvey J, 2003, NEUROPHARMACOLOGY, V44, P845, DOI 10.1016/S0028-3908(03)00076-5
   Hasegawa M, 2010, NEUROSCI LETT, V479, P240, DOI 10.1016/j.neulet.2010.05.070
   Hatalski CG, 2000, NEUROSCIENCE, V101, P571, DOI 10.1016/S0306-4522(00)00386-9
   Haugen BR, 2009, BEST PRACT RES CL EN, V23, P793, DOI 10.1016/j.beem.2009.08.003
   HENRY C, 1994, J NEUROENDOCRINOL, V6, P341, DOI 10.1111/j.1365-2826.1994.tb00591.x
   Jahnke S, 2007, BRAIN RES, V1143, P60, DOI 10.1016/j.brainres.2007.01.109
   JARRARD LE, 1993, BEHAV NEURAL BIOL, V60, P9, DOI 10.1016/0163-1047(93)90664-4
   Johnson NJT, 1996, PSYCHOPHARMACOLOGY, V124, P355, DOI 10.1007/BF02247441
   Johnson PJ, 2003, EQUINE VET J, V35, P296, DOI 10.2746/042516403776148309
   Kamal A, 1999, BRAIN RES, V824, P238, DOI 10.1016/S0006-8993(99)01215-9
   Kar BR, 2008, BEHAV BRAIN FUNCT, V4, DOI 10.1186/1744-9081-4-31
   KOLLER WC, 1992, NEUROLOGY, V42, P33
   KORANYI L, 1976, PSYCHOPHARMACOLOGY, V49, P197, DOI 10.1007/BF00427290
   LEBLANC MO, 1979, EXP NEUROL, V66, P220, DOI 10.1016/0014-4886(79)90076-1
   LEGRAND J, 1983, J PHYSIOLOGY PARIS, V78, P603
   Levay EA, 2008, BEHAV BRAIN RES, V191, P164, DOI 10.1016/j.bbr.2008.03.021
   LEVITSKY DA, 1995, J NUTR, V125, pS2212, DOI 10.1093/jn/125.suppl_8.2212S
   LEVITSKY DA, 1970, NATURE, V225, P468, DOI 10.1038/225468a0
   Lisboa PC, 2006, HORM METAB RES, V38, P295, DOI 10.1055/s-2006-925390
   Lucas A, 1998, BRIT MED J, V317, P1481, DOI 10.1136/bmj.317.7171.1481
   Lund TD, 2005, ENDOCRINOLOGY, V146, P797, DOI 10.1210/en.2004-1158
   Manhaes AC, 2008, BEHAV BRAIN RES, V193, P216, DOI 10.1016/j.bbr.2008.05.018
   Mann P E, 2001, Prog Brain Res, V133, P251
   Marques RG, 2009, ACTA CIR BRAS, V24, P69, DOI 10.1590/S0102-86502009000100015
   MEISAMI E, 1992, J ENDOCRINOL, V135, P495, DOI 10.1677/joe.0.1350495
   MOLINA VA, 1987, PHARMACOL BIOCHEM BE, V26, P417, DOI 10.1016/0091-3057(87)90139-0
   MORGANE PJ, 1993, NEUROSCI BIOBEHAV R, V17, P91, DOI 10.1016/S0149-7634(05)80234-9
   Morley-Fletcher S, 2003, EUR J NEUROSCI, V18, P3367, DOI 10.1111/j.1460-9568.2003.03070.x
   Morley-Fletcher S, 2003, BRAIN RES, V989, P246, DOI 10.1016/S0006-8993(03)03293-1
   MOURA EG, 1987, BRAZ J MED BIOL RES, V20, P407
   Myers B, 2007, AM J PHYSIOL-GASTR L, V292, pG1622, DOI 10.1152/ajpgi.00080.2007
   OKEEFE J, 1990, PROG BRAIN RES, V83, P301
   OLTON DS, 1978, BRAIN RES, V139, P295, DOI 10.1016/0006-8993(78)90930-7
   Passos MCF, 2000, NUTR RES, V20, P1603, DOI 10.1016/S0271-5317(00)00246-3
   Pereira-da-Silva MS, 2009, BEHAV BRAIN RES, V205, P286, DOI 10.1016/j.bbr.2009.05.031
   Pilhatsch M, 2010, BEHAV BRAIN RES, V214, P187, DOI 10.1016/j.bbr.2010.05.016
   Plagemann Andreas, 2005, Metabolic Syndrome and Related Disorders, V3, P222, DOI 10.1089/met.2005.3.222
   PORTERFIELD SP, 1993, ENDOCR REV, V14, P94, DOI 10.1210/er.14.1.94
   RANDT CT, 1973, ARCH NEUROL-CHICAGO, V28, P167, DOI 10.1001/archneur.1973.00490210047005
   RAVELLI GP, 1976, NEW ENGL J MED, V295, P349, DOI 10.1056/NEJM197608122950701
   Redei EE, 2001, NEUROPSYCHOPHARMACOL, V24, P632, DOI 10.1016/S0893-133X(00)00229-3
   RODGERS B, 1978, DEV MED CHILD NEUROL, V20, P421, DOI 10.1111/j.1469-8749.1978.tb15242.x
   Rodgers RJ, 1997, BRAZ J MED BIOL RES, V30, P289, DOI 10.1590/S0100-879X1997000300002
   SHAH GV, 1988, ENDOCRINOLOGY, V122, P1883, DOI 10.1210/endo-122-5-1883
   Shepard JD, 2000, BRAIN RES, V861, P288, DOI 10.1016/S0006-8993(00)02019-9
   Shepard JD, 2003, BRAIN RES, V963, P203, DOI 10.1016/S0006-8993(02)03978-1
   STRUPP BJ, 1995, J NUTR, V125, pS2221, DOI 10.1093/jn/125.suppl_8.2221S
   TAMASY V, 1986, DEV PSYCHOBIOL, V19, P537, DOI 10.1002/dev.420190606
   TAMASY V, 1986, PSYCHONEUROENDOCRINO, V11, P91, DOI 10.1016/0306-4530(86)90035-1
   Taylor VH, 2007, OBES REV, V8, P409, DOI 10.1111/j.1467-789X.2007.00401.x
   Thompson CC, 2000, CEREB CORTEX, V10, P939, DOI 10.1093/cercor/10.10.939
   Torner L, 2002, EUR J NEUROSCI, V15, P1381, DOI 10.1046/j.1460-9568.2002.01965.x
   UDANI P M, 1992, Indian Journal of Pediatrics, V59, P165, DOI 10.1007/BF02759978
   UNGER J, 1980, J CLIN ENDOCR METAB, V51, P590, DOI 10.1210/jcem-51-3-590
   Vallee M, 1997, J NEUROSCI, V17, P2626
   VALZELLI L, 1972, NEUROPHARMACOLOGY, V11, P17, DOI 10.1016/0028-3908(72)90052-4
   Venero C, 2005, GENE DEV, V19, P2152, DOI 10.1101/gad.346105
   Wang B, 2003, EUR J CLIN NUTR, V57, P1351, DOI 10.1038/sj.ejcn.1601704
   WINICK M, 1966, J NUTR, V89, P300, DOI 10.1093/jn/89.3.300
   Yehuda R, 2009, J PSYCHIATR RES, V43, P877, DOI 10.1016/j.jpsychires.2008.12.003
   Zoeller RT, 2004, J NEUROENDOCRINOL, V16, P809, DOI 10.1111/j.1365-2826.2004.01243.x
NR 102
TC 24
Z9 24
U1 1
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0091-3057
J9 PHARMACOL BIOCHEM BE
JI Pharmacol. Biochem. Behav.
PD NOV
PY 2011
VL 100
IS 1
BP 165
EP 173
DI 10.1016/j.pbb.2011.07.007
PG 9
WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy
GA 838OP
UT WOS:000296302400023
PM 21777608
OA hybrid
DA 2025-06-11
ER

PT J
AU Galarregui, C
   Zulet, MA
   Cantero, I
   Marín-Alejandre, BA
   Monreal, JI
   Elorz, M
   Benito-Boillos, A
   Herrero, JI
   Tur, JA
   Abete, I
   Martínez, JA
AF Galarregui, Cristina
   Angeles Zulet, Maria
   Cantero, Irene
   Araceli Marin-Alejandre, Bertha
   Ignacio Monreal, Jose
   Elorz, Mariana
   Benito-Boillos, Alberto
   Ignacio Herrero, Jose
   Antoni Tur, Josep
   Abete, Itziar
   Alfredo Martinez, Jose
TI Interplay of Glycemic Index, Glycemic Load, and Dietary Antioxidant
   Capacity with Insulin Resistance in Subjects with a Cardiometabolic Risk
   Profile
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE antioxidants; glucose; diet; diabetes; precision nutrition
ID FOOD-FREQUENCY QUESTIONNAIRE; OXIDATIVE STRESS; ASSOCIATION;
   COMPLICATIONS; INFLAMMATION; SENSITIVITY; CONSUMPTION; DISEASE; PROTEIN;
   OBESITY
AB Background: Dietary total antioxidant capacity (TAC), glycemic index (GI), and glycemic load (GL) are accepted indicators of diet quality, which have an effect on diet-disease relationships. The aim of this study was to evaluate potential associations of dietary TAC, GI, and GL with variables related to nutritive status and insulin resistance (IR) risk in cardiometabolic subjects. Methods: A total of 112 overweight or obese adults (age: 50.8 +/- 9 years old) were included in the trial. Dietary intake was assessed by a validated 137-item food frequency questionnaire (FFQ), which was also used to calculate the dietary TAC, GI, and GL. Anthropometrics, blood pressure, body composition by dual-energy X-ray absorptiometry (DXA), glycemic and lipid profiles, C-reactive protein (CRP), as well as fatty liver quantification by magnetic resonance imaging (MRI) were assessed. Results: Subjects with higher values of TAC had significantly lower circulating insulin concentration and homeostatic model assessment of insulin resistance (HOMA-IR). Participants with higher values of HOMA-IR showed significantly higher GI and GL. Correlation analyses showed relevant inverse associations of GI and GL with TAC. A regression model evidenced a relationship of HOMA-IR with TAC, GI, and GL. Conclusion: This data reinforces the concept that dietary TAC, GI, and GL are potential markers of diet quality, which have an impact on the susceptible population with a cardiometabolic risk profile.
C1 [Galarregui, Cristina; Angeles Zulet, Maria; Cantero, Irene; Araceli Marin-Alejandre, Bertha; Abete, Itziar; Alfredo Martinez, Jose] Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.
   [Galarregui, Cristina; Angeles Zulet, Maria; Cantero, Irene; Araceli Marin-Alejandre, Bertha; Abete, Itziar; Alfredo Martinez, Jose] Univ Navarra, Ctr Nutr Res, Pamplona 31008, Spain.
   [Angeles Zulet, Maria; Antoni Tur, Josep; Abete, Itziar; Alfredo Martinez, Jose] Inst Salud Carlos III, Biomed Res Ctr Network Physiopathol Obes & Nutr C, Madrid 28029, Spain.
   [Angeles Zulet, Maria; Ignacio Monreal, Jose; Elorz, Mariana; Benito-Boillos, Alberto; Ignacio Herrero, Jose; Alfredo Martinez, Jose] Navarra Inst Hlth Res IdiSNA, Pamplona 31008, Spain.
   [Ignacio Monreal, Jose] Univ Navarra, Clin Chem Dept, Univ Clin Navarra, Pamplona 31008, Spain.
   [Elorz, Mariana; Benito-Boillos, Alberto] Univ Navarra, Univ Clin Navarra, Radiodiagnost Dept, Pamplona 31008, Spain.
   [Ignacio Herrero, Jose] Univ Navarra, Liver Unit, Univ Clin Navarra, Pamplona 31008, Spain.
   [Antoni Tur, Josep] Univ Illes Balears, Res Grp Community Nutr & Oxidat Stress, E-07122 Palma De Mallorca, Spain.
   [Alfredo Martinez, Jose] Madrid Inst Adv Studies IMDEA Food, Precis Nutr & Cardiometab Hlth Dept, Madrid 28049, Spain.
C3 University of Navarra; University of Navarra; Instituto de Salud Carlos
   III; University of Navarra; University of Navarra; University of
   Navarra; University of Navarra; Universitat de les Illes Balears; IMDEA
   Food Institute
RP Abete, I (corresponding author), Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.; Abete, I (corresponding author), Univ Navarra, Ctr Nutr Res, Pamplona 31008, Spain.; Abete, I (corresponding author), Inst Salud Carlos III, Biomed Res Ctr Network Physiopathol Obes & Nutr C, Madrid 28029, Spain.
EM cgalarregui@alumni.unav.es; mazulet@unav.es; icantero.1@alumni.unav.es;
   bmarin.1@alumni.unav.es; jimonreal@unav.es; marelorz@unav.es;
   albenitob@unav.es; iherrero@unav.es; pep.tur@uib.es; iabetego@unav.es;
   jalfmtz@unav.es
RI Zulet, M./H-1317-2017; Carlón, Mariana/ABD-5128-2021; Tur,
   Josep/AAE-5748-2020; Tur, Josep/F-5576-2014; Stefanadis,
   Christodoulos/ABH-2232-2020; Abete, Itziar/H-4827-2017; Benito,
   Alberto/AAD-4201-2020; Martinez Hernandez, J Alfredo/K-8709-2014
OI Tur, Josep/0000-0002-6940-0761; Marin Alejandre, Bertha
   Araceli/0000-0003-0741-8197; Stefanadis,
   Christodoulos/0000-0001-5974-6454; Abete, Itziar/0000-0002-6475-5387;
   Benito, Alberto/0000-0002-1527-0092; Elorz Carlon,
   Mariana/0000-0002-1580-3629; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941
FU Health Department of the Government of Navarra [61/2015]; CIBERobn
   (Physiopathology of Obesity and Nutrition); Fundacio La Marato de TV3
   [201630.10]; Congelados de Navarra; Ministerio de Educacion, Cultura y
   Deporte [FPU17/06330]; Government of Navarra
FX This research was funded by the Health Department of the Government of
   Navarra (61/2015), CIBERobn (Physiopathology of Obesity and Nutrition),
   and Fundacio La Marato de TV3 (201630.10). C.G. was partially supported
   by fellowships from Congelados de Navarra, Government of Navarra, and
   Ministerio de Educacion, Cultura y Deporte (FPU17/06330).
CR Abete I, 2011, NUTR METAB CARDIOVAS, V21, pB1, DOI 10.1016/j.numecd.2011.05.001
   Acosta AM, 2002, REV MED CHILE, V130, P1227
   Arikawa AY, 2015, NUTR RES, V35, P7, DOI 10.1016/j.nutres.2014.10.005
   Atkinson FS, 2008, DIABETES CARE, V31, P2281, DOI 10.2337/dc08-1239
   Hassimotto NMA, 2008, J AGR FOOD CHEM, V56, P11727, DOI 10.1021/jf8026149
   Betteridge DJ, 2000, METABOLISM, V49, P3, DOI 10.1016/S0026-0495(00)80077-3
   Bhupathiraju SN, 2014, AM J CLIN NUTR, V100, P218, DOI 10.3945/ajcn.113.079533
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Brownlee M, 2005, DIABETES, V54, P1615, DOI 10.2337/diabetes.54.6.1615
   Cefalu WT, 2001, EXP BIOL MED, V226, P13, DOI 10.1177/153537020122600103
   de la Iglesia R, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17111877
   de la Iglesia R, 2013, INT J MOL SCI, V14, P6903, DOI 10.3390/ijms14046903
   Franzini L, 2008, CURR OPIN CLIN NUTR, V11, P471, DOI 10.1097/MCO.0b013e328303be79
   FRIEDEWALD WT, 1972, CLIN CHEM, V18
   Gastaldelli A, 2013, METABOLISM, V62, P1330, DOI 10.1016/j.metabol.2013.05.001
   Gögebakan Ö, 2011, CIRCULATION, V124, P2829, DOI 10.1161/CIRCULATIONAHA.111.033274
   Griffith JA, 2008, NUTRITION, V24, P401, DOI 10.1016/j.nut.2007.12.017
   Halvorsen BL, 2006, AM J CLIN NUTR, V84, P95, DOI 10.1093/ajcn/84.1.95
   Halvorsen BL, 2002, J NUTR, V132, P461, DOI 10.1093/jn/132.3.461
   Hamer M, 2007, J HYPERTENS, V25, P2361, DOI 10.1097/HJH.0b013e3282efc214
   Hermsdorff HHM, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-59
   JENKINS DJA, 1981, AM J CLIN NUTR, V34, P362, DOI 10.1093/ajcn/34.3.362
   Liu SM, 2000, AM J CLIN NUTR, V71, P1455
   Lopez-Legarrea P, 2014, NUTRITION, V30, P424, DOI 10.1016/j.nut.2013.09.009
   MARTINMORENO JM, 1993, INT J EPIDEMIOL, V22, P512, DOI 10.1093/ije/22.3.512
   Montonen J, 2004, DIABETES CARE, V27, P362, DOI 10.2337/diacare.27.2.362
   Moreiras O., 2016, Tablas de composicion de alimentos
   Neuhouser ML, 2006, J NUTR, V136, P1604, DOI 10.1093/jn/136.6.1604
   Pellegrini N, 2003, J NUTR, V133, P2812, DOI 10.1093/jn/133.9.2812
   Pellegrini N, 2006, MOL NUTR FOOD RES, V50, P1030, DOI 10.1002/mnfr.200600067
   Perez-Cornago A, 2014, CLIN NUTR, V33, P1061, DOI 10.1016/j.clnu.2013.11.011
   Pérez-Matute P, 2009, CURR OPIN PHARMACOL, V9, P771, DOI 10.1016/j.coph.2009.08.005
   Pitsavos C, 2005, AM J CLIN NUTR, V82, P694, DOI 10.1093/ajcn/82.3.694
   Puchau B, 2009, J AM COLL NUTR, V28, P648, DOI 10.1080/07315724.2009.10719797
   Puchau B, 2010, NUTRITION, V26, P534, DOI 10.1016/j.nut.2009.06.017
   Rahimi R, 2005, BIOMED PHARMACOTHER, V59, P365, DOI 10.1016/j.biopha.2005.07.002
   Rautiainen S, 2008, AM J CLIN NUTR, V87, P1247, DOI 10.1093/ajcn/87.5.1247
   Rösen P, 2001, DIABETES-METAB RES, V17, P189, DOI 10.1002/dmrr.196
   Salvatore S, 2005, J AGR FOOD CHEM, V53, P9465, DOI 10.1021/jf051806r
   Schulze MB, 2004, AM J CLIN NUTR, V80, P348, DOI 10.1093/ajcn/80.2.348
   Serafini M, 2004, REDOX REP, V9, P145, DOI 10.1179/135100004225004814
   University of Sydney Glycemic Index, 2006, U SYDNEY GLYCEMIC IN
   Valtuena S, 2008, AM J CLIN NUTR, V87, P1290, DOI 10.1093/ajcn/87.5.1290
   Yu JS, 2016, GASTROENT RES PRACT, V2016, DOI 10.1155/2016/2862173
   Zulet MA, 2011, NUTR HOSP, V26, P16, DOI 10.3305/nh.2011.26.1.5050
NR 45
TC 29
Z9 29
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD NOV
PY 2018
VL 19
IS 11
AR 3662
DI 10.3390/ijms19113662
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HC0ZM
UT WOS:000451528500378
PM 30463312
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Yamagata, AS
   Mansur, RB
   Rizzo, LB
   Rosenstock, T
   McIntyre, RS
   Brietzke, E
AF Yamagata, Ana Sayuri
   Mansur, Rodrigo Barbachan
   Rizzo, Lucas Bortolotto
   Rosenstock, Tatiana
   McIntyre, Roger S.
   Brietzke, Elisa
TI Selfish brain and selfish immune system interplay: A theoretical
   framework for metabolic comorbidities of mood disorders
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Bipolar disorder; Major depressive disorder; Brain energy metabolism;
   Immune system energy metabolism; Metabolic syndrome; Inflammation
ID MAJOR DEPRESSIVE DISORDER; ELEVATED SERUM-LEVELS; C-REACTIVE PROTEIN;
   BIPOLAR DISORDER; INSULIN-RESISTANCE; GLUCOSE-METABOLISM; 3T3-L1
   ADIPOCYTES; PREFRONTAL CORTEX; HORMONE-SECRETION; ALLOSTATIC LOAD
AB According to the "selfish brain" theory, the brain regulates its own energy supply influencing the peripheral metabolism and food intake according to its needs. The immune system has been likewise "selfish" due to independent energy consumption; and it may compete with the brain (another high energy consumer) for glucose. In mood disorders, stress in mood episodes or physiological stress activate homeostasis mechanisms from the brain and the immune system to solve the imbalance. The interaction between the selfish brain and the selfish immune system may explain various conditions of medical impairment in mood disorders, such as Metabolic Syndrome (MetS), obesity, type 2 diabetes mellitus (T2DM) and immune dysregulation. The objective of this study is to comprehensively review the literature regarding the competition between the brain and the immune system for energy substrate. Targeting the energetic regulation of the brain and the immune system and their cross-talk open alternative treatments and a different approach in the study of general medical comorbidities in mood disorders, although more investigation is needed. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Yamagata, Ana Sayuri] Univ Sao Paulo, Inst Biosci, R Matao 14,321 Butanta, BR-05508090 Sao Paulo, SP, Brazil.
   [Yamagata, Ana Sayuri; Mansur, Rodrigo Barbachan; Rizzo, Lucas Bortolotto; Brietzke, Elisa] Fed Univ Sao Paulo Unifesp, Res Grp Behav & Mol Neurosci Bipolar Disorder, Dept Psychiat, R Pedro de Toledo,669 3rd-Floor, BR-04039032 Sao Paulo, SP, Brazil.
   [Mansur, Rodrigo Barbachan; McIntyre, Roger S.] Univ Toronto, Mood Disorders Psychopharmachol Unit, 399 Bathurst St,MP 9-325, Toronto, ON M5T 2S8, Canada.
   [Rosenstock, Tatiana] Santa Casa Sao Paulo Med Sch, Dept Physiol Sci, R Doutor Cesario Motto Jr,61 Vila Buarque, BR-01221020 Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade Federal de Sao Paulo (UNIFESP);
   University of Toronto
RP Yamagata, AS (corresponding author), Rua Pedro de Toledo,669-3rd Floor, BR-04039032 Sao Paulo, SP, Brazil.
EM ana.yamagata@usp.br
RI Brietzke, Elisa/G-9559-2012; Mansur, Rodrigo/N-7131-2019; McIntyre,
   Roger/AAU-1000-2020; Rosenstock, Tatiana/N-1949-2013; Rizzo,
   Lucas/C-5418-2013; Rosenstock, Tatiana/HME-1849-2023
OI Yamagata, Ana Sayuri/0000-0002-6919-6369; Rosenstock,
   Tatiana/0000-0003-1153-7412
CR Agostini F, 2010, CURR OPIN CLIN NUTR, V13, P58, DOI 10.1097/MCO.0b013e328332f946
   Ahrén B, 2000, DIABETOLOGIA, V43, P393, DOI 10.1007/s001250051322
   Aktas O, 2007, ARCH NEUROL-CHICAGO, V64, P185, DOI 10.1001/archneur.64.2.185
   Alesci S, 2005, J CLIN ENDOCR METAB, V90, P2522, DOI 10.1210/jc.2004-1667
   Andreazza AC, 2010, ARCH GEN PSYCHIAT, V67, P360, DOI 10.1001/archgenpsychiatry.2010.22
   Andreazza AC, 2007, J PSYCHIATR RES, V41, P523, DOI 10.1016/j.jpsychires.2006.07.013
   [Anonymous], STRESS
   Ben-Shachar D, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003676
   Booth NJ, 2012, BIRKHAUSER ADV INFEC, P1, DOI 10.1007/978-3-0346-0219-8_1
   Brietzke E, 2012, PROG NEURO-PSYCHOPH, V39, P1, DOI 10.1016/j.pnpbp.2012.05.004
   Brietzke E, 2011, EXPERT REV NEUROTHER, V11, P1017, DOI [10.1586/ERN.10.185, 10.1586/ern.10.185]
   Brietzke E, 2009, J AFFECT DISORDERS, V116, P214, DOI 10.1016/j.jad.2008.12.001
   CALDER PC, 1995, P NUTR SOC, V54, P65, DOI 10.1079/PNS19950038
   Calkin CV, 2015, BRIT J PSYCHIAT, V206, P52, DOI 10.1192/bjp.bp.114.152850
   Capuron L, 2008, BIOL PSYCHIAT, V64, P896, DOI 10.1016/j.biopsych.2008.05.019
   Caro-Maldonado A, 2012, SEMIN IMMUNOL, V24, P405, DOI 10.1016/j.smim.2012.12.002
   Cataldo AM, 2010, AM J PATHOL, V177, P575, DOI 10.2353/ajpath.2010.081068
   Cervantes P, 2001, J PSYCHIATR NEUROSCI, V26, P411
   Chan O, 2007, DIABETES, V56, P1120, DOI 10.2337/db06-1102
   Chen YL, 2011, PSYCHIAT RES, V188, P224, DOI 10.1016/j.psychres.2010.10.029
   Chiarugi A, 2005, FASEB J, V19, P1783, DOI 10.1096/fj.05-4200rev
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   Cunha AB, 2008, EUR ARCH PSY CLIN N, V258, P300, DOI 10.1007/s00406-007-0797-0
   Cunha ABM, 2006, NEUROSCI LETT, V398, P215, DOI 10.1016/j.neulet.2005.12.085
   Czepielewski L, 2013, REV BRAS PSIQUIATR, V35, P88, DOI [10.1016/j.rbp.2012.07.004, 10.1016/j.rbp.2012.00.000]
   Daban C, 2005, PSYCHIAT CLIN N AM, V28, P469, DOI 10.1016/j.psc.2005.01.005
   Dager SR, 2004, ARCH GEN PSYCHIAT, V61, P450, DOI 10.1001/archpsyc.61.5.450
   Dantzer R, 2004, BRAIN BEHAV IMMUN, V18, P1, DOI 10.1016/j.bbi.2003.09.008
   Dantzer R, 2006, NEUROL CLIN, V24, P441, DOI 10.1016/j.ncl.2006.03.003
   de Sousa RT, 2014, EXPERT OPIN THER TAR, V18, P1131, DOI 10.1517/14728222.2014.940893
   del Rey A, 2006, P NATL ACAD SCI USA, V103, P16039, DOI 10.1073/pnas.0607076103
   Dickerson F, 2007, PROG NEURO-PSYCHOPH, V31, P952, DOI 10.1016/j.pnpbp.2007.02.018
   do Prado CH, 2013, PSYCHONEUROENDOCRINO, V38, P667, DOI 10.1016/j.psyneuen.2012.08.005
   Drevets WC, 1997, NATURE, V386, P824, DOI 10.1038/386824a0
   Fagiolini A, 2008, CNS DRUGS, V22, P655, DOI 10.2165/00023210-200822080-00004
   Fleet-Michaliszyn SB, 2008, J CLIN PSYCHIAT, V69, P1892, DOI 10.4088/JCP.v69n1207
   FONG YM, 1990, J CLIN INVEST, V85, P1896, DOI 10.1172/JCI114651
   Gardner A, 2003, J AFFECT DISORDERS, V76, P55, DOI 10.1016/S0165-0327(02)00067-8
   Gerriets VA, 2012, TRENDS IMMUNOL, V33, P168, DOI 10.1016/j.it.2012.01.010
   Gleeson M, 2011, NAT REV IMMUNOL, V11, P607, DOI 10.1038/nri3041
   Grande I, 2012, PHYSIOL BEHAV, V106, P46, DOI 10.1016/j.physbeh.2011.10.029
   Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
   Gurpegui M, 2012, PROG NEURO-PSYCHOPH, V37, P169, DOI 10.1016/j.pnpbp.2012.01.014
   Hajek T, 2005, BIPOLAR DISORD, V7, P286, DOI 10.1111/j.1399-5618.2005.00182.x
   Hamdani N, 2013, J AFFECT DISORDERS, V148, P444, DOI 10.1016/j.jad.2012.11.034
   HASSELBALCH SG, 1995, AM J PHYSIOL-ENDOC M, V268, pE1161, DOI 10.1152/ajpendo.1995.268.6.E1161
   Hitze Britta, 2010, Front Neuroenergetics, V2, P7, DOI 10.3389/fnene.2010.00007
   Holsboer F, 2000, NEUROPSYCHOPHARMACOL, V23, P477, DOI 10.1016/S0893-133X(00)00159-7
   Hung CI, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/1471-244X-14-185
   Insel TR, 2005, JAMA-J AM MED ASSOC, V294, P2221, DOI 10.1001/jama.294.17.2221
   Ishida K, 1997, REGUL PEPTIDES, V70, P179, DOI 10.1016/S0167-0115(97)01002-1
   Iwamoto K, 2005, HUM MOL GENET, V14, P241, DOI 10.1093/hmg/ddi022
   Jaramillo Carlos Lopez, 2013, Rev Colomb Psiquiatr, V42, P283, DOI 10.1016/S0034-7450(13)70021-0
   Kahl KG, 2015, PSYCHONEUROENDOCRINO, V58, P1, DOI 10.1016/j.psyneuen.2015.04.008
   Kamble P, 2015, EUR J PHARMACOL, V749, P12, DOI 10.1016/j.ejphar.2014.12.020
   Kapczinski F, 2008, REV BRAS PSIQUIATR, V30, P243, DOI 10.1590/S1516-44462008000300011
   Kapczinski F, 2008, NEUROSCI BIOBEHAV R, V32, P675, DOI 10.1016/j.neubiorev.2007.10.005
   Karabatsiakis A, 2014, TRANSL PSYCHIAT, V4, DOI 10.1038/tp.2014.44
   KeltikangasJarvinen L, 1996, METABOLISM, V45, P614, DOI 10.1016/S0026-0495(96)90033-5
   Kiecolt-Glaser JK, 2003, P NATL ACAD SCI USA, V100, P9090, DOI 10.1073/pnas.1531903100
   Koponen H, 2015, BMC PSYCHIATRY, V15, DOI 10.1186/s12888-015-0567-x
   Kubera Britta, 2012, Front Neuroenergetics, V4, P4, DOI 10.3389/fnene.2012.00004
   Lawlor DA, 2006, DIABETOLOGIA, V49, P41, DOI 10.1007/s00125-005-0040-3
   Lee Yong-Ho, 2005, Curr Diab Rep, V5, P70
   Lindqvist D, 2009, BIOL PSYCHIAT, V66, P287, DOI 10.1016/j.biopsych.2009.01.030
   Liu CS, 2014, CNS NEUROL DISORD-DR, V13, P1693
   MacIver NJ, 2008, J LEUKOCYTE BIOL, V84, P949, DOI 10.1189/jlb.0108024
   Manalai P, 2012, BIPOLAR DISORD, V14, P90, DOI 10.1111/j.1399-5618.2012.00983.x
   Mansur RB, 2015, NEUROSCI BIOBEHAV R, V52, P89, DOI 10.1016/j.neubiorev.2014.12.017
   Mansur RB, 2013, PROG NEURO-PSYCHOPH, V43, P66, DOI 10.1016/j.pnpbp.2012.12.004
   Mansur Rodrigo Barbachan, 2012, Trends Psychiatry Psychother., V34, P121
   Marco C, 2015, PSYCHIAT RES, V228, P945, DOI 10.1016/j.psychres.2015.06.013
   Mayberg HS, 1999, AM J PSYCHIAT, V156, P675
   McEwen BS, 2003, BIOL PSYCHIAT, V54, P200, DOI 10.1016/S0006-3223(03)00177-X
   McIntyre Roger S, 2005, Ann Clin Psychiatry, V17, P83, DOI 10.1080/10401230590932380
   McIntyre RS, 2016, CURR MOL MED, V16, P104
   McIntyre Roger S, 2008, Dialogues Clin Neurosci, V10, P203
   Modabbernia A, 2013, BIOL PSYCHIAT, V74, P15, DOI 10.1016/j.biopsych.2013.01.007
   Moretti A, 2003, MOL PSYCHIATR, V8, P773, DOI 10.1038/sj.mp.4001353
   Morris G, 2015, BMC MED, V13, DOI 10.1186/s12916-015-0310-y
   Morris G, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-205
   Mulder AH, 2005, AM J PHYSIOL-ENDOC M, V289, pE627, DOI 10.1152/ajpendo.00079.2004
   Nakata Akinori, 2012, Methods Mol Biol, V934, P39, DOI 10.1007/978-1-62703-071-7_3
   Noto C, 2014, NEUROIMMUNOMODULAT, V21, P131, DOI 10.1159/000356549
   Oomen HAPC, 1996, CLIN ENDOCRINOL, V45, P215, DOI 10.1046/j.1365-2265.1996.d01-1558.x
   Opolski Melissa, 2005, Clin Pract Epidemiol Ment Health, V1, P18, DOI 10.1186/1745-0179-1-18
   Pace TWW, 2007, BRAIN BEHAV IMMUN, V21, P9, DOI 10.1016/j.bbi.2006.08.009
   Pariante CM, 2001, BIOL PSYCHIAT, V49, P391, DOI 10.1016/S0006-3223(00)01088-X
   Pedersen Bente Klarlund, 2011, J Exp Biol, V214, P337, DOI 10.1242/jeb.048074
   Pellerin L, 1997, J NEUROCHEM, V69, P2132
   Peters A, 2006, ENDOCRINOLOGY, V147, P4550, DOI 10.1210/en.2006-0815
   Peters A, 2004, NEUROSCI BIOBEHAV R, V28, P143, DOI 10.1016/j.neubiorev.2004.03.002
   Peters A, 2015, NEUROSCI BIOBEHAV R, V56, P139, DOI 10.1016/j.neubiorev.2015.07.001
   Peters A, 2011, FRONT NEUROSCI-SWITZ, V5, DOI 10.3389/fnins.2011.00074
   Peters Achim, 2009, Front Neuroenergetics, V1, P2, DOI 10.3389/neuro.14.002.2009
   Posener JA, 2000, ARCH GEN PSYCHIAT, V57, P755, DOI 10.1001/archpsyc.57.8.755
   Prossin AR, 2015, NEURAL PLAST, V2015, DOI 10.1155/2015/939780
   Raison CL, 2006, TRENDS IMMUNOL, V27, P24, DOI 10.1016/j.it.2005.11.006
   Raison CL, 2003, AM J PSYCHIAT, V160, P1554, DOI 10.1176/appi.ajp.160.9.1554
   REINMUTH OM, 1965, ARCH NEUROL-CHICAGO, V12, P49, DOI 10.1001/archneur.1965.00460250053007
   Rizzo LB, 2013, BIPOLAR DISORD, V15, P832, DOI 10.1111/bdi.12121
   Rosenblat JD, 2015, J AFFECT DISORDERS, V188, P149, DOI 10.1016/j.jad.2015.08.058
   Rothermundt M, 2001, J AFFECT DISORDERS, V66, P89, DOI 10.1016/S0165-0327(00)00321-9
   Ruzickova M, 2003, CAN J PSYCHIAT, V48, P458, DOI 10.1177/070674370304800705
   Saxena Tarun Kumar, 2014, J Assoc Physicians India, V62, P484
   SCHEDLOWSKI M, 1993, J CLIN IMMUNOL, V13, P119, DOI 10.1007/BF00919268
   Schroeter ML, 2009, MOL PSYCHIATR, V14, P235, DOI 10.1038/mp.2008.85
   Seaquist ER, 2001, DIABETES, V50, P2203, DOI 10.2337/diabetes.50.10.2203
   Segal KR, 1996, DIABETES, V45, P988, DOI 10.2337/diabetes.45.7.988
   Shao L, 2008, ANN MED, V40, P281, DOI 10.1080/07853890801923753
   Sicras A, 2008, BIPOLAR DISORD, V10, P607, DOI 10.1111/j.1399-5618.2008.00599.x
   Spiliotaki M, 2006, PSYCHONEUROENDOCRINO, V31, P748, DOI 10.1016/j.psyneuen.2006.02.006
   STEPHENS JM, 1991, J BIOL CHEM, V266, P21839
   Straub RH, 2010, J INTERN MED, V267, P543, DOI 10.1111/j.1365-2796.2010.02218.x
   Straub RH, 2014, ARTHRITIS RES THER, V16, DOI 10.1186/ar4688
   Straub RH, 2014, ANN NY ACAD SCI, V1318, P7, DOI 10.1111/nyas.12409
   Taylor V, 2006, J CLIN PSYCHIAT, V67, P1034, DOI 10.4088/JCP.v67n0704
   Tedla Yared, 2011, Ethiop Med J, V49, P211
   Thomas AJ, 2005, AM J PSYCHIAT, V162, P175, DOI 10.1176/appi.ajp.162.1.175
   Tong QC, 2007, CELL METAB, V5, P383, DOI 10.1016/j.cmet.2007.04.001
   Tsigos C, 1997, NEUROENDOCRINOLOGY, V66, P54, DOI 10.1159/000127219
   Uranova N, 2001, BRAIN RES BULL, V55, P597, DOI 10.1016/S0361-9230(01)00528-7
   Vancampfort D, 2015, DEPRESS ANXIETY, V32, P763, DOI 10.1002/da.22387
   Vander Heiden MG, 2001, MOL CELL BIOL, V21, P5899, DOI 10.1128/MCB.21.17.5899-5912.2001
   Videbech P, 2000, ACTA PSYCHIAT SCAND, V101, P11, DOI 10.1034/j.1600-0447.2000.101001011.x
   WALKER EA, 1990, AM J PSYCHIAT, V147, P1656
   Walsh NP, 2011, EXERC IMMUNOL REV, V17, P64
   Weiner M, 2011, ANN CLIN PSYCHIATRY, V23, P40
   Wensveen FM, 2015, SEMIN IMMUNOL, V27, P322, DOI 10.1016/j.smim.2015.10.006
   Wieck A, 2013, BRAIN BEHAV IMMUN, V34, P47, DOI 10.1016/j.bbi.2013.07.005
   Yim CY, 2012, EUR PSYCHIAT, V27, P223, DOI 10.1016/j.eurpsy.2011.02.004
   Young EA, 2001, NEUROPSYCHOPHARMACOL, V25, P267, DOI 10.1016/S0893-133X(00)00236-0
   Yuksel C, 2015, MOL PSYCHIATR, V20, P1079, DOI 10.1038/mp.2015.13
NR 133
TC 21
Z9 22
U1 0
U2 14
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD JAN
PY 2017
VL 72
BP 43
EP 49
DI 10.1016/j.neubiorev.2016.11.010
PG 7
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA EI8WW
UT WOS:000392789900004
PM 27871787
DA 2025-06-11
ER

PT J
AU Burton, WN
   Edington, DW
   Schultz, AB
AF Burton, Wayne N.
   Edington, Dee W.
   Schultz, Alyssa B.
TI Lifestyle Medicine and Worker Productivity
SO AMERICAN JOURNAL OF LIFESTYLE MEDICINE
LA English
DT Article
DE health risks; interventions; lifestyle medicine; productivity
ID BODY-MASS INDEX; HEALTH-CARE COSTS; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; WORKPLACE HEALTH; EMPLOYEE HEALTH; ECONOMIC COSTS;
   SMOKING STATUS; MENTAL-HEALTH; ASSOCIATION
AB The issue of employee productivity has become a major concern for companies. Inefficiency can occur at every stage of production either as poor design, worker limitation, or other factors. It is generally assumed that a healthy worker is more productive than an unhealthy worker. As early as 1776 Adam Smith observed and published in The Wealth of Nations that poor worker health was a detriment to industrial productivity. The objective of this article is to review the literature documenting the gain or loss of productivity related to the health of workers, as well as any lifestyle management strategies that can be used to improve employee health and productivity. The impact of employee obesity, smoking, physical activity, sleep, and behavioral health on productivity will be explored. By identifying and addressing health risks that impair worker performance, lifestyle medicine professionals can demonstrate a significant return on investment by creating a healthier and more productive work force.
C1 [Burton, Wayne N.] Univ Illinois, Chicago, IL USA.
   [Edington, Dee W.] Edington Associates, Ann Arbor, MI USA.
   [Schultz, Alyssa B.] NCRC, Global Hlth Management Res Core, Bldg 520,1600 Huron Pkwy, Ann Arbor, MI 48109 USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital
RP Schultz, AB (corresponding author), NCRC, Global Hlth Management Res Core, Bldg 520,1600 Huron Pkwy, Ann Arbor, MI 48109 USA.
EM abelaire@umich.edu
OI Schultz, Alyssa/0000-0001-8149-066X
CR [Anonymous], MENT HLTH MENT HLTH
   Arena VC, 2006, J OCCUP ENVIRON MED, V48, P1118, DOI 10.1097/01.jom.0000241050.26059.2b
   BERTERA RL, 1991, J OCCUP ENVIRON MED, V33, P1119, DOI 10.1097/00043764-199111000-00006
   Bunn WB, 2006, J OCCUP ENVIRON MED, V48, P1099, DOI 10.1097/01.jom.0000243406.08419.74
   Burton WN, 2008, J OCCUP ENVIRON MED, V50, P1139, DOI 10.1097/JOM.0b013e318188b8eb
   Burton WN, 2017, J OCCUP ENVIRON MED, V59, P177, DOI 10.1097/JOM.0000000000000934
   Burton WN, 2014, J OCCUP ENVIRON MED, V56, P919, DOI 10.1097/JOM.0000000000000257
   Burton WN, 2008, INT J WORKPLACE HEAL, V1, P78, DOI 10.1108/17538350810893883
   Burton WN, 2006, J OCCUP ENVIRON MED, V48, P252, DOI 10.1097/01.jom.0000201563.18108.af
   Burton WN, 2005, J OCCUP ENVIRON MED, V47, P343, DOI 10.1097/01.jom.0000158719.57957.c6
   Burton WN, 1999, J OCCUP ENVIRON MED, V41, P863, DOI 10.1097/00043764-199910000-00007
   Burton WN, 2004, J OCCUP ENVIRON MED, V46, P1048, DOI 10.1097/01.jom.0000141830.72507.32
   Burton WN, 2004, J OCCUP ENVIRON MED, V46, pS38, DOI 10.1097/01.jom.0000126687.49652.44
   Burton WN, 1998, J OCCUP ENVIRON MED, V40, P786, DOI 10.1097/00043764-199809000-00007
   Centers for Disease Control and Prevention, 2014, 2014 SURG GEN REP HL
   Chakravarthy MV, 2002, MAYO CLIN PROC, V77, P165
   Chen CY, 2018, POPUL HEALTH MANAG, V21, P46, DOI 10.1089/pop.2016.0169
   CONTI DJ, 1994, J OCCUP ENVIRON MED, V36, P983
   Edington D., 2003, A Practical Approach to Occupational and Environmental Medicine, P40
   Ford ES, 2005, DIABETES CARE, V28, P2745, DOI 10.2337/diacare.28.11.2745
   Gates DM, 2008, J OCCUP ENVIRON MED, V50, P39, DOI 10.1097/JOM.0b013e31815d8db2
   Gingerich SB, 2018, AM J HEALTH PROMOT, V32, P1091, DOI 10.1177/0890117117722517
   Halpern MT, 2001, TOB CONTROL, V10, P233, DOI 10.1136/tc.10.3.233
   Haufe S, 2019, LANCET PUBLIC HEALTH, V4, pE343, DOI 10.1016/S2468-2667(19)30075-1
   Jacobsen BH, 2001, J OCCUP ENVIRON MED, V43, P1019
   Kleinman NL, 2009, J CLIN PSYCHIAT, V70, P1098, DOI 10.4088/JCP.08m04264
   Lechner L, 1997, J OCCUP ENVIRON MED, V39, P827, DOI 10.1097/00043764-199709000-00005
   Loeppke R, 2007, J OCCUP ENVIRON MED, V49, P712, DOI 10.1097/JOM.0b013e318133a4be
   Mokdad AH, 2018, JAMA-J AM MED ASSOC, V319, P1444, DOI 10.1001/jama.2018.0158
   Musich S, 2001, J OCCUP ENVIRON MED, V43, P534, DOI 10.1097/00043764-200106000-00005
   National Institute of Mental Health, MENT HLTH STAT
   Ozminkowski RI, 2004, J MANAGE CARE PHARM, V10, P467
   Robbins R, 2019, AM J HEALTH PROMOT, V33, P1009, DOI 10.1177/0890117119841407
   Schultz AB, 2007, J OCCUP REHABIL, V17, P547, DOI 10.1007/s10926-007-9096-x
   Schultz AB, 2018, AM J HEALTH PROMOT, V32, P1639, DOI 10.1177/0890117118790621c
   Serxner SA, 2001, J OCCUP ENVIRON MED, V43, P347, DOI 10.1097/00043764-200104000-00010
   Thompson D, 1998, AM J HEALTH PROMOT, V13, P120, DOI 10.4278/0890-1171-13.2.120
   Tucker LA, 1998, AM J HEALTH PROMOT, V12, P202, DOI 10.4278/0890-1171-12.3.202
   van Amelsvoort LGPM, 2006, OCCUP MED-OXFORD, V56, P210, DOI 10.1093/occmed/kqj026
   Wagner SL, 2016, INT J OCCUP ENV MED, V7, P1, DOI 10.15171/ijoem.2016.607
   Xu X, 2015, AM J PREV MED, V48, P326, DOI 10.1016/j.amepre.2014.10.012
   Yarborough CM III, 2018, J OCCUP ENVIRON MED, V60, P97, DOI 10.1097/JOM.0000000000001220
   YEN LTC, 1992, J OCCUP ENVIRON MED, V34, P428
NR 43
TC 5
Z9 5
U1 2
U2 19
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1559-8276
EI 1559-8284
J9 AM J LIFESTYLE MED
JI Am. J. Lifestyle Med.
PD MAR
PY 2021
VL 15
IS 2
BP 136
EP 139
AR 1559827620948008
DI 10.1177/1559827620948008
EA AUG 2020
PG 4
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA QV8SF
UT WOS:000561091100001
PM 33790700
OA Green Published
DA 2025-06-11
ER

PT J
AU Svartberg, J
   Agledahl, I
   Figenschau, Y
   Sildnes, T
   Waterloo, K
   Jorde, R
AF Svartberg, J.
   Agledahl, I.
   Figenschau, Y.
   Sildnes, T.
   Waterloo, K.
   Jorde, R.
TI Testosterone treatment in elderly men with subnormal testosterone levels
   improves body composition and BMD in the hip
SO INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
LA English
DT Article
DE testosterone; hypogonadism; treatment; elderly; body composition
ID MIDDLE-AGED MEN; BONE-MINERAL DENSITY; QUALITY-OF-LIFE; OLDER MEN;
   BIOAVAILABLE TESTOSTERONE; TRANSDERMAL TESTOSTERONE; METABOLIC SYNDROME;
   EXOGENOUS TESTOSTERONE; ANDROGEN DEFICIENCY; SERUM TESTOSTERONE
AB Our intention was to examine if subnormal testosterone levels in older men were associated with a reduction in quality of life and physical and mental health, and secondly to examine if testosterone treatment could improve these conditions. We performed a nested case-control study and a 1-year testosterone intervention study. Men with subnormal testosterone had significantly higher weight, fat mass and abdominal adipose tissue. They also had significantly higher glucose and insulin levels, and they had higher triglyceride levels. Testosterone treatment had a large impact on body composition with reduced fat mass and abdominal adipose tissue and increased fat-free mass, but it did not affect weight and glucose and lipid metabolism. Bone mineral density in the hip was significantly higher after the testosterone treatment. Older men with subnormal testosterone levels had an unfavorable metabolic profile. Testosterone treatment improved body composition, but it did not reverse the unfavorable metabolic profile.
C1 [Svartberg, J.; Agledahl, I.; Jorde, R.] Univ Hosp N Norway, Dept Med, N-9038 Tromso, Norway.
   [Svartberg, J.; Jorde, R.] Univ Tromso, Inst Clin Med, Tromso, Norway.
   [Figenschau, Y.] Univ Hosp N Norway, Dept Med Biochem, N-9038 Tromso, Norway.
   [Figenschau, Y.] Univ Tromso, Dept Med Biochem, Tromso, Norway.
   [Sildnes, T.] Univ Hosp N Norway, Dept Radiol, N-9038 Tromso, Norway.
   [Waterloo, K.] Univ Hosp N Norway, Dept Neurol, N-9038 Tromso, Norway.
   [Waterloo, K.] Univ Tromso, Dept Psychol, Tromso, Norway.
C3 UiT The Arctic University of Tromso; University Hospital of North
   Norway; UiT The Arctic University of Tromso; UiT The Arctic University
   of Tromso; University Hospital of North Norway; UiT The Arctic
   University of Tromso; UiT The Arctic University of Tromso; University
   Hospital of North Norway; UiT The Arctic University of Tromso;
   University Hospital of North Norway; UiT The Arctic University of Tromso
RP Svartberg, J (corresponding author), Univ Hosp N Norway, Dept Med, N-9038 Tromso, Norway.
EM johan.svartberg@unn.no
CR Amory JK, 2004, J CLIN ENDOCR METAB, V89, P503, DOI 10.1210/jc.2003-031110
   Barrett-Connor E, 2004, J CLIN ENDOCR METAB, V89, P501, DOI 10.1210/jc.2003-032160
   Barrett-Connor E, 1999, J CLIN ENDOCR METAB, V84, P573, DOI 10.1210/jc.84.2.573
   Bhasin S, 2006, J CLIN ENDOCR METAB, V91, P1995, DOI 10.1210/jc.2005-2847
   BONAA KH, 1992, CIRCULATION, V86, P394
   Carani C, 1997, NEW ENGL J MED, V337, P91, DOI 10.1056/NEJM199707103370204
   Cavallini G, 2004, UROLOGY, V63, P641, DOI 10.1016/j.urology.2003.11.009
   English KM, 2000, CIRCULATION, V102, P1906, DOI 10.1161/01.CIR.102.16.1906
   Feldman HA, 2002, J CLIN ENDOCR METAB, V87, P589, DOI 10.1210/jc.87.2.589
   GRAY A, 1991, J CLIN ENDOCR METAB, V73, P1016, DOI 10.1210/jcem-73-5-1016
   Harman SM, 2001, J CLIN ENDOCR METAB, V86, P724, DOI 10.1210/jc.86.2.724
   Heinemann L A J, 2005, J Endocrinol Invest, V28, P34
   Jorde R, 2006, J NEUROL, V253, P464, DOI 10.1007/s00415-005-0027-5
   Kenny AM, 2002, J GERONTOL A-BIOL, V57, pM321, DOI 10.1093/gerona/57.5.M321
   Kenny AM, 2001, J GERONTOL A-BIOL, V56, pM266, DOI 10.1093/gerona/56.5.M266
   Kenny AM, 2004, J GERONTOL A-BIOL, V59, P75
   Laaksonen DE, 2005, J CLIN ENDOCR METAB, V90, P712, DOI 10.1210/jc.2004-0970
   Laaksonen DE, 2004, DIABETES CARE, V27, P1036, DOI 10.2337/diacare.27.5.1036
   Ly LP, 2001, J CLIN ENDOCR METAB, V86, P4078, DOI 10.1210/jc.86.9.4078
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Page ST, 2005, J CLIN ENDOCR METAB, V90, P1502, DOI 10.1210/jc.2004-1933
   Power M, 2005, QUAL LIFE RES, V14, P2197, DOI 10.1007/s11136-005-7380-9
   Purnell JQ, 2000, J CLIN ENDOCR METAB, V85, P977, DOI 10.1210/jc.85.3.977
   Reddy P, 2000, J CLIN PHARM THER, V25, P421, DOI 10.1046/j.1365-2710.2000.00309.x
   Sih R, 1997, J CLIN ENDOCR METAB, V82, P1661, DOI 10.1210/jc.82.6.1661
   Snyder PJ, 1999, J CLIN ENDOCR METAB, V84, P1966, DOI 10.1210/jc.84.6.1966
   Snyder PJ, 1999, J CLIN ENDOCR METAB, V84, P2647, DOI 10.1210/jc.84.8.2647
   Svartberg J, 2003, EUR J ENDOCRINOL, V149, P145, DOI 10.1530/eje.0.1490145
   Vermeulen A, 1999, J CLIN ENDOCR METAB, V84, P3666, DOI 10.1210/jc.84.10.3666
   Wittert GA, 2003, J GERONTOL A-BIOL, V58, P618
   2006, INT ACTIVITY QUESTIO
NR 32
TC 130
Z9 136
U1 0
U2 2
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0955-9930
J9 INT J IMPOT RES
JI Int. J. Impot. Res.
PD JUL
PY 2008
VL 20
IS 4
BP 378
EP 387
DI 10.1038/ijir.2008.19
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 326HB
UT WOS:000257648100006
PM 18480825
DA 2025-06-11
ER

PT J
AU Barbagallo, M
   Belvedere, M
   Dominguez, LJ
AF Barbagallo, Mario
   Belvedere, Mario
   Dominguez, Ligia J.
TI Magnesium homeostasis and aging
SO MAGNESIUM RESEARCH
LA English
DT Review
DE magnesium; aging; Mg deficiency; anti-aging; oxidative stress; chronic
   inflammation; diabetes; hypertension; dementia
ID C-REACTIVE PROTEIN; TYPE-2 DIABETES-MELLITUS; DIETARY MAGNESIUM;
   INTRACELLULAR MAGNESIUM; METABOLIC SYNDROME; RAT MODEL;
   INTESTINAL-ABSORPTION; PARATHYROID-HORMONE; GLUCOSE-METABOLISM;
   ENDOTHELIAL-CELLS
AB Aging is very often associated with magnesium (Mg) deficit. Total plasma magnesium concentrations are remarkably constant in healthy subjects throughout life, while total body Mg and Mg in the intracellular compartment tend to decrease with age. Dietary Mg deficiencies are common in the elderly population. Other frequent causes of Mg deficits in the elderly include reduced Mg intestinal absorption, reduced Mg bone stores, and excess urinary loss. Secondary Mg deficit in aging may result from different conditions and diseases often observed in the elderly (i.e. insulin resistance and/or type 2 diabetes mellitus) and drugs (i.e. use of hypermagnesuric diuretics). Chronic Mg deficits have been linked to an increased risk of numerous preclinical and clinical outcomes, mostly observed in the elderly population, including hypertension, stroke, atherosclerosis, ischemic heart disease, cardiac arrhythmias, glucose intolerance, insulin resistance, type 2 diabetes mellitus, endothelial dysfunction, vascular remodeling, alterations in lipid metabolism, platelet aggregation/thrombosis, inflammation, oxidative stress, cardiovascular mortality, asthma, chronic fatigue, as well as depression and other neuropsychiatric disorders. Both aging and Mg deficiency have been associated to excessive production of oxygen-derived free radicals and low-grade inflammation. Chronic inflammation and oxidative stress are also present in several age-related diseases, such as many vascular and metabolic conditions, as well as frailty, muscle loss and sarcopenia, and altered immune responses, among others. Mg deficit associated to aging may be at least one of the pathophysiological links that may help to explain the interactions between inflammation and oxidative stress with the aging process and many age-related diseases.
C1 [Barbagallo, Mario; Belvedere, Mario; Dominguez, Ligia J.] Univ Palermo, Geriatr Unit, Dept Internal Med & Emergent Pathol, I-90133 Palermo, Italy.
C3 University of Palermo
RP Barbagallo, M (corresponding author), Viale F Scaduto 6-C, I-90144 Palermo, Italy.
EM mabar@unipa.it
RI ; BARBAGALLO, MARIO/K-4794-2017
OI dominguez, ligia j/0000-0003-1466-8610; BARBAGALLO,
   MARIO/0000-0002-1349-6530
CR AFANASEV IB, 1995, ANALYST, V120, P859, DOI 10.1039/an9952000859
   Altura BM, 2003, AM J HYPERTENS, V16, P701, DOI 10.1016/S0895-7061(03)00987-7
   Amighi J, 2004, STROKE, V35, P22, DOI 10.1161/01.STR.0000105928.95124.1F
   BAKER MR, 1980, AGE AGEING, V9, P249, DOI 10.1093/ageing/9.4.249
   BALON TW, 1995, AM J PHYSIOL-ENDOC M, V269, pE745, DOI 10.1152/ajpendo.1995.269.4.E745
   Barbagallo M, 1999, HYPERTENSION, V34, P1002, DOI 10.1161/01.HYP.34.4.1002
   Barbagallo M, 2000, J AM GERIATR SOC, V48, P1111, DOI 10.1111/j.1532-5415.2000.tb04788.x
   Barbagallo M, 1999, HYPERTENSION, V34, P76, DOI 10.1161/01.HYP.34.1.76
   BARBAGALLO M, 2009, CURRENT PHA IN PRESS
   Barbagallo Mario, 2007, Am J Ther, V14, P375, DOI 10.1097/01.mjt.0000209676.91582.46
   Barbagallo M, 2007, ARCH BIOCHEM BIOPHYS, V458, P40, DOI 10.1016/j.abb.2006.05.007
   Barbagallo Mario, 2003, Molecular Aspects of Medicine, V24, P39, DOI 10.1016/S0098-2997(02)00090-0
   Bernardini D, 2005, FRONT BIOSCI-LANDMRK, V10, P1177, DOI 10.2741/1610
   Berner Y N, 2002, J Nutr Health Aging, V6, P237
   Blache D, 2006, FREE RADICAL BIO MED, V41, P277, DOI 10.1016/j.freeradbiomed.2006.04.008
   BRILLA LR, 1992, J AM COLL NUTR, V11, P326
   Brilla LR, 1995, MED EXERC NUTR HLTH, V4, P230
   BRUGERE MC, 2000, BIOCHIM BIOPHYS ACTA, V1501, P91
   Bussière FI, 2003, LIFE SCI, V73, P499, DOI 10.1016/S0024-3205(03)00291-1
   Chaudhary DP, 2004, MAGNESIUM RES, V17, P293
   Chien MM, 1999, J BIOL CHEM, V274, P7059, DOI 10.1074/jbc.274.11.7059
   COHEN L, 1992, MAGNESIUM-B, V14, P133
   Coudray C, 2005, J TRACE ELEM MED BIO, V19, P97, DOI 10.1016/j.jtemb.2005.07.002
   Coudray C, 1999, MAGNESIUM RES, V12, P109
   Davidovic Mladen, 2004, ScientificWorldJournal, V4, P544
   DICKENS BF, 1992, FEBS LETT, V311, P187, DOI 10.1016/0014-5793(92)81098-7
   Dominguez LJ, 2006, AM J CLIN NUTR, V84, P419
   Dominguez LJ, 1998, CLIN SCI, V95, P137, DOI 10.1042/CS19980082
   Ford ES, 2003, J NUTR, V133, P2879, DOI 10.1093/jn/133.9.2879
   FRANCESCHI C, 2000, ANN NY ACAD SCI, V908, P879
   Fung TT, 2003, J AM COLL NUTR, V22, P533, DOI 10.1080/07315724.2003.10719332
   Galan P, 1997, MAGNESIUM RES, V10, P321
   GALLAGHER JC, 1980, J LAB CLIN MED, V95, P373
   GALLAND L, 1988, MAGNESIUM, V7, P290
   Guerrero-Romero F, 2002, INT J OBESITY, V26, P469, DOI 10.1038/sj.ijo.0801954
   Guerrero-Romero F, 2006, DIABETES-METAB RES, V22, P471, DOI 10.1002/dmrr.644
   GULLESTAD L, 1994, J AM COLL NUTR, V13, P45
   Hans CP, 2003, MAGNESIUM RES, V16, P13
   Hartwig A, 2001, MUTAT RES-FUND MOL M, V475, P113, DOI 10.1016/S0027-5107(01)00074-4
   He K, 2006, CIRCULATION, V113, P1675, DOI 10.1161/CIRCULATIONAHA.105.588327
   Hunt CD, 2006, AM J CLIN NUTR, V84, P843, DOI 10.1093/ajcn/84.4.843
   Iwasaki Y, 2007, J ENDOCRINOL INVEST, V30, P513, DOI 10.1007/BF03346336
   Kao WHL, 1999, ARCH INTERN MED, V159, P2151, DOI 10.1001/archinte.159.18.2151
   Keenoy BHY, 2000, J AM COLL NUTR, V19, P374, DOI 10.1080/07315724.2000.10718934
   Killilea DW, 2008, P NATL ACAD SCI USA, V105, P5768, DOI 10.1073/pnas.0712401105
   King DE, 2007, MAGNESIUM RES, V20, P32
   King DE, 2005, J AM COLL NUTR, V24, P166, DOI 10.1080/07315724.2005.10719461
   Kramer JH, 2003, EXP BIOL MED, V228, P665, DOI 10.1177/153537020322800604
   KurantsinMills J, 1997, BRIT J NUTR, V78, P845, DOI 10.1079/BJN19970200
   Lauretani F, 2003, J APPL PHYSIOL, V95, P1851, DOI 10.1152/japplphysiol.00246.2003
   LO CS, 1968, GERONTOLOGY, V14, P1
   Maier JAM, 2004, BBA-MOL BASIS DIS, V1689, P13, DOI 10.1016/j.bbadis.2004.01.002
   MARTIN BJ, 1991, Q J MED, V78, P177
   MATSUNOBU S, 1990, J NUTR BIOCHEM, V1, P167, DOI 10.1016/0955-2863(90)90018-G
   Mazur A, 2007, ARCH BIOCHEM BIOPHYS, V458, P48, DOI 10.1016/j.abb.2006.03.031
   MCKEEHAN WL, 1978, NATURE, V275, P756, DOI 10.1038/275756a0
   Murck H, 2002, NUTR NEUROSCI, V5, P375, DOI 10.1080/1028415021000039194
   Padro L, 2002, J Nutr Health Aging, V6, P31
   PAOLISSO G, 1994, AM J PHYSIOL, V266, P261
   PETERSEN B, 1977, ACTA MED SCAND, V201, P31
   RAYSSIGUIER Y, 1993, MAGNESIUM RES, V6, P373
   RESNICK LM, 1991, HYPERTENSION, V17, P951, DOI 10.1161/01.HYP.17.6.951
   RESNICK LM, 1993, DIABETOLOGIA, V36, P767, DOI 10.1007/BF00401149
   ROCK E, 1995, J NUTR, V125, P1205
   Rodríguez-Morán M, 2004, MAGNESIUM RES, V17, P189
   RUBIN H, 1975, P NATL ACAD SCI USA, V72, P3551, DOI 10.1073/pnas.72.9.3551
   RUDE RK, 1981, ANNU REV MED, V32, P245, DOI 10.1146/annurev.me.32.020181.001333
   Rude RK, 2009, J AM COLL NUTR, V28, P131, DOI 10.1080/07315724.2009.10719764
   Saris NEL, 2000, CLIN CHIM ACTA, V294, P1, DOI 10.1016/S0009-8981(99)00258-2
   Sgambato A, 1999, J CELL PHYSIOL, V180, P245, DOI 10.1002/(SICI)1097-4652(199908)180:2<245::AID-JCP12>3.0.CO;2-R
   Shechter M, 2000, AM HEART J, V140, P212, DOI 10.1067/mhj.2000.107553
   SHERWOOD RA, 1986, GERONTOLOGY, V32, P105, DOI 10.1159/000212773
   Song YQ, 2005, DIABETES CARE, V28, P1438, DOI 10.2337/diacare.28.6.1438
   Tam M, 2003, EUR J CLIN NUTR, V57, P1193, DOI 10.1038/sj.ejcn.1601689
   Touyz RM, 2004, FRONT BIOSCI-LANDMRK, V9, P1278, DOI 10.2741/1316
   TSUNEMATSU K, 1987, J JPN SOC MAGNES RES, V6, P33
   Vaquero M P, 2002, J Nutr Health Aging, V6, P147
   Weglicki W. B., 1996, Magnesium Research, V9, P3
   WEGLICKI WB, 1992, AM J PHYSIOL, V263, pR734
   Weglicki WB, 1996, CARDIOVASC RES, V31, P677, DOI 10.1016/0008-6363(95)00196-4
   Wolf Federica I., 2003, Molecular Aspects of Medicine, V24, P3, DOI 10.1016/S0098-2997(02)00087-0
   WOLF FI, 1999, FRONT BIOSCI, V4, P1
   YANG XY, 1990, J AM COLL NUTR, V9, P308
   Yang Y, 2006, BIOMETALS, V19, P71, DOI 10.1007/s10534-005-6898-1
   Zofkova I, 1995, Magnes Res, V8, P77
NR 85
TC 153
Z9 160
U1 0
U2 38
PU JOHN LIBBEY EUROTEXT LTD
PI MONTROUGE
PA 127 AVE DE LA REPUBLIQUE, 92120 MONTROUGE, FRANCE
SN 0953-1424
EI 1952-4021
J9 MAGNESIUM RES
JI Magnes. Res.
PD DEC
PY 2009
VL 22
IS 4
BP 235
EP 246
DI 10.1684/mrh.2009.0187
PG 12
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 536UZ
UT WOS:000273070700002
PM 20228001
DA 2025-06-11
ER

PT J
AU Sibiya, T
   Ghazi, T
   Chuturgoon, A
AF Sibiya, Thabani
   Ghazi, Terisha
   Chuturgoon, Anil
TI The Potential of Spirulina platensis to Ameliorate the Adverse
   Effects of Highly Active Antiretroviral Therapy (HAART)
SO NUTRIENTS
LA English
DT Review
DE HAART; ARVs; Spirulina platensis; oxidative stress; HIV; antioxidant;
   inflammation; HAART toxicity; MetS
ID HUMAN-IMMUNODEFICIENCY-VIRUS; IN-VITRO EVALUATION; TENOFOVIR DISOPROXIL
   FUMARATE; HIV PREEXPOSURE PROPHYLAXIS; INDUCED OXIDATIVE STRESS;
   NF-KAPPA-B; C-PHYCOCYANIN; ANTIINFLAMMATORY ACTIVITY; METABOLIC
   SYNDROME; ANTIOXIDANT ACTIVITY
AB The human immunodeficiency virus (HIV) is one of the most prevalent diseases globally. It is estimated that 37.7 million people are infected with HIV globally, and 8.2 million persons are infected with the virus in South Africa. The highly active antiretroviral therapy (HAART) involves combining various types of antiretroviral drugs that are dependent on the infected person's viral load. HAART helps regulate the viral load and prevents its associated symptoms from progressing into acquired immune deficiency syndrome (AIDS). Despite its success in prolonging HIV-infected patients' lifespans, the use of HAART promotes metabolic syndrome (MetS) through an inflammatory pathway, excess production of reactive oxygen species (ROS), and mitochondrial dysfunction. Interestingly, Spirulina platensis (SP), a blue-green microalgae commonly used as a traditional food by Mexican and African people, has been demonstrated to mitigate MetS by regulating oxidative and inflammatory pathways. SP is also a potent antioxidant that has been shown to exhibit immunological, anticancer, anti-inflammatory, anti-aging, antidiabetic, antibacterial, and antiviral properties. This review is aimed at highlighting the biochemical mechanism of SP with a focus on studies linking SP to the inhibition of HIV, inflammation, and oxidative stress. Further, we propose SP as a potential supplement for HIV-infected persons on lifelong HAART.
C1 [Sibiya, Thabani; Ghazi, Terisha; Chuturgoon, Anil] Univ KwaZulu Natal, Coll Hlth Sci, Sch Lab Med & Med Sci, Discipline Med Biochem & Chem Pathol, Howard Coll Campus, ZA-4013 Durban, South Africa.
C3 University of Kwazulu Natal
RP Chuturgoon, A (corresponding author), Univ KwaZulu Natal, Coll Hlth Sci, Sch Lab Med & Med Sci, Discipline Med Biochem & Chem Pathol, Howard Coll Campus, ZA-4013 Durban, South Africa.
EM thabani585@gmail.com; terishaghazi@gmail.com; chutur@ukzn.ac.za
RI Ghazi, Terisha/AAU-5164-2021; Chuturgoon, Anil/AAE-5068-2021
OI Ghazi, Terisha/0000-0002-0179-213X; Sibiya, Thabani/0000-0001-6648-2813
FU National Research Foundation Innovation Doctoral Scholarship [130023];
   University of KwaZulu Natal, College of Health Sciences Masters and
   Doctoral Research Scholarship
FX Grant sponsor: National Research Foundation Innovation Doctoral
   Scholarship; Grant number: 130023; Grant sponsor: University of KwaZulu
   Natal, College of Health Sciences Masters and Doctoral Research
   Scholarship.
CR Abdelkhalek NKM, 2015, ENVIRON SCI POLLUT R, V22, P3023, DOI 10.1007/s11356-014-3578-0
   Adikwu E, 2013, PHARM PHARM, V4, P651, DOI [10.4236/pp.2013.49092, DOI 10.4236/PP.2013.49092]
   Aiuti F, 2006, AIDS REV, V8, P88
   Ali S.K., 2012, INT J PHARM PHARM SC, V4, P9
   Ama Moor VJ, 2021, ACTA SCI PHARM SCI, V5, P50
   Anbarasan V, 2011, INT J PHARM SCI RES, V2, P2616, DOI 10.13040/IJPSR.0975-8232.2(10).2616-18
   [Anonymous], 2007, Indicators of Sustainable Development: Guidelines and Methodologies-Third Edition: Methodology Sheets, P104
   [Anonymous], What Is HAART?
   [Anonymous], HIV / AIDS
   Antonelli M, 2022, BIOL LIFE SCI FORUM, V12, P6, DOI [10.3390/IECN2022-12362, DOI 10.3390/IECN2022-12362]
   Aounallah M, 2016, CYTOKINE GROWTH F R, V28, P1, DOI 10.1016/j.cytogfr.2016.01.001
   Apostolova N, 2010, BRIT J PHARMACOL, V160, P2069, DOI 10.1111/j.1476-5381.2010.00866.x
   Asghari A., 2016, J APPL BIOTECHNOL RE, V3, P345
   Ashaolu TJ, 2021, INT J BIOL MACROMOL, V193, P2320, DOI 10.1016/j.ijbiomac.2021.11.064
   Ashenafi W, 2020, E AFR J HLTH BIOMEDI, V4, P13
   Awodele O, 2012, J INFECT DEV COUNTR, V6, P79, DOI 10.3855/jidc.1906
   Ayehunie S, 1998, J ACQ IMMUN DEF SYND, V18, P7, DOI 10.1097/00042560-199805010-00002
   Bai SK, 2005, EXP MOL MED, V37, P323, DOI 10.1038/emm.2005.42
   Baker RG, 2011, CELL METAB, V13, P11, DOI 10.1016/j.cmet.2010.12.008
   Balachandran P, 2006, INT IMMUNOPHARMACOL, V6, P1808, DOI 10.1016/j.intimp.2006.08.001
   Barbaro G, 2009, CURR DIABETES REP, V9, P37, DOI 10.1007/s11892-009-0008-7
   Bashandy SAE, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/7174351
   Bhat VB, 2000, BIOCHEM BIOPH RES CO, V275, P20, DOI 10.1006/bbrc.2000.3270
   Blas-García A, 2011, CURR PHARM DESIGN, V17, P4076, DOI 10.2174/138161211798764951
   Boffito M., 2004, PRN NOTEB, V9, P15
   Bonomini F, 2015, AGING DIS, V6, P109, DOI 10.14336/AD.2014.0305
   Borroto-Esoda K, 2006, ANTIVIR THER, V11, P377
   Brouwer ES, 2014, EPIDEMIOLOGY, V25, P406, DOI 10.1097/EDE.0000000000000041
   Brown LAM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0095500
   Canale D, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0103055
   Cao Y, 2013, BMC INFECT DIS, V13, DOI 10.1186/1471-2334-13-301
   Carr A, 1998, LANCET, V351, P1881, DOI 10.1016/S0140-6736(98)03391-1
   Chamorro G, 2006, NUTR NEUROSCI, V9, P207, DOI 10.1080/10284150600929748
   Chang JL, 2018, ANN INTERN MED, V169, P146, DOI [10.7326/M17-2252, 10.7326/m17-2252]
   Chen YF, 2019, TOXICOL SCI, V172, P445, DOI 10.1093/toxsci/kfz203
   Cherng SC, 2007, LIFE SCI, V81, P1431, DOI 10.1016/j.lfs.2007.09.009
   Choudhary M, 2007, ECOTOX ENVIRON SAFE, V66, P204, DOI 10.1016/j.ecoenv.2006.02.002
   Chu WL, 2010, BMC COMPLEM ALTERN M, V10, DOI 10.1186/1472-6882-10-53
   CIFERRI O, 1983, MICROBIOL REV, V47, P551, DOI 10.1128/MMBR.47.4.551-578.1983
   Csanyi G., 2014, OXIDATIVE STRESS CAR
   Cunningham WE, 1999, AM J MED, V107, P137, DOI 10.1016/S0002-9343(99)00195-3
   De Luca A, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0225381
   de Ruiter A, 2014, HIV MED, V15, P1, DOI 10.1111/hiv.12185
   del Valle LG., 2013, J Virol Microbiol, V13, P15
   Deng RT, 2010, CARDIOVASC THER, V28, pe33, DOI 10.1111/j.1755-5922.2010.00200.x
   Dorr P, 2005, ANTIMICROB AGENTS CH, V49, P4721, DOI 10.1128/AAC.49.11.4721-4732.2005
   dos Santos WR., 2013, J AIDS CLIN RES, V4, P2
   eacsociety, European AIDS Clinical Society Guidelines v12.0
   Eastone JA, 1997, ANN INTERN MED, V127, P948, DOI 10.7326/0003-4819-127-10-199711150-00017
   Eggleton JS., 2021, STATPEARLS
   Estrada JEP, 2001, FARMACO, V56, P497
   Estrada V, 2016, HIV MED, V17, P653, DOI 10.1111/hiv.12368
   Fernandez-Fernandez B, 2011, AIDS RES TREAT, V2011, DOI 10.1155/2011/354908
   Ferruzzi MG, 2007, NUTR RES, V27, P1, DOI 10.1016/j.nutres.2006.12.003
   Fettiplace A, 2017, JAIDS-J ACQ IMM DEF, V74, P423, DOI [10.1097/QAI.0000000000001269, 10.1097/qai.0000000000001269]
   Finamore A, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/3247528
   Fonner VA, 2016, AIDS, V30, P1973, DOI 10.1097/QAD.0000000000001145
   Ford N, 2018, AIDS, V32, P17, DOI [10.1097/QAD.0000000000001671, 10.1097/qad.0000000000001671]
   Gershwin M. E., 2007, Spirulina in human nutrition and health.
   Gilks CF, 2006, LANCET, V368, P505, DOI 10.1016/S0140-6736(06)69158-7
   Glover M, 2014, ANTIVIR RES, V111, P136, DOI 10.1016/j.antiviral.2014.09.010
   González R, 1999, PHARMACOL RES, V39, P55, DOI 10.1006/phrs.1998.0409
   Grigsby IF, 2010, THER CLIN RISK MANAG, V6, P41
   Grover P, 2021, SAUDI J BIOL SCI, V28, P1853, DOI 10.1016/j.sjbs.2020.12.037
   Gulick RM, 2004, NEW ENGL J MED, V350, P1850, DOI 10.1056/NEJMoa031772
   Gunes S, 2017, PHARM BIOL, V55, P1824, DOI 10.1080/13880209.2017.1331249
   Gutiérrez F, 2014, AIDS REV, V16, P199
   Hardy N, 2004, PHARMACOTHERAPY, V24, P198, DOI 10.1592/phco.24.2.198.33141
   Hare CB, 2008, CLIN INFECT DIS, V47, P421, DOI 10.1086/589867
   Hayashi T, 1996, J NAT PROD, V59, P83, DOI 10.1021/np960017o
   Hazuda DJ, 2000, SCIENCE, V287, P646, DOI 10.1126/science.287.5453.646
   Henrikson R., 1989, EARTH FOOD SPIRULINA
   Hernández-Corona A, 2002, ANTIVIR RES, V56, P279, DOI 10.1016/S0166-3542(02)00132-8
   Hoffmann C, 2017, HIV MED, V18, P56, DOI 10.1111/hiv.12468
   Hong SY, 2015, JAIDS-J ACQ IMM DEF, V68, P463, DOI 10.1097/QAI.0000000000000509
   Hoseini SM, 2013, MINI-REV MED CHEM, V13, P1231, DOI 10.2174/1389557511313080009
   Hosikian A, 2010, INT J CHEM ENG, V2010, DOI 10.1155/2010/391632
   Hu Z H, 2001, Se Pu, V19, P85
   Iyer Uma M., 1999, AGE YEARS, V22, P1
   Izadi M., 2018, Asian J Green Chem, V2, P364, DOI [10.22034/ajgc.2018.63597, DOI 10.22034/AJGC.2018.63597]
   Jadaun P, 2018, CYTOTECHNOLOGY, V70, P523, DOI 10.1007/s10616-017-0121-4
   Jensen GS, 2016, J MED FOOD, V19, P645, DOI 10.1089/jmf.2015.0143
   Jensen GS, 2015, J MED FOOD, V18, P535, DOI 10.1089/jmf.2014.0083
   Jiang F, 2006, HYPERTENSION, V48, P950, DOI 10.1161/01.HYP.0000242336.58387.1f
   Joventino Ivan P, 2012, J Complement Integr Med, V9, P17, DOI 10.1515/1553-3840.1534
   Kahana SY, 2013, AIDS BEHAV, V17, P41, DOI 10.1007/s10461-012-0159-4
   Kakuda TN, 2000, CLIN THER, V22, P685, DOI 10.1016/S0149-2918(00)90004-3
   Kamata K, 2014, SCI REP-UK, V4, DOI 10.1038/srep04919
   Kamble S.P., 2013, J. Appl. Pharm. Sci, V3, P149, DOI [10.7324/JAPS.2013.3826, DOI 10.7324/JAPS.2013.3826]
   Karkos PD, 2011, EVID-BASED COMPL ALT, V2011, P1, DOI 10.1093/ecam/nen058
   Katsuura S, 2009, MOL NUTR FOOD RES, V53, P1396, DOI 10.1002/mnfr.200800566
   Khan M, 2006, AM J PHYSIOL-HEART C, V290, pH2136, DOI 10.1152/ajpheart.01072.2005
   Khan M, 2006, J CARDIOVASC PHARM, V47, P9, DOI 10.1097/01.fjc.0000191520.48404.27
   Khan Z, 2005, CURR PHARM BIOTECHNO, V6, P373, DOI 10.2174/138920105774370607
   Kim DS, 2020, J FOOD BIOCHEM, V44, DOI 10.1111/jfbc.13282
   Kitahata MM, 1996, NEW ENGL J MED, V334, P701, DOI 10.1056/NEJM199603143341106
   Koskey S, 2013, AFR J HLTH SCI, V24, P1
   Kränkel N, 2019, EUR J PREV CARDIOL, V26, P701, DOI 10.1177/2047487318805158
   Law WP, 2004, AIDS, V18, P1169, DOI 10.1097/00002030-200405210-00010
   Lennox JL, 2014, ANN INTERN MED, V161, P461, DOI 10.7326/M14-1084
   Li Vecchi V, 2014, CURR PHARM DESIGN, V20, P4975, DOI 10.2174/1381612819666131206104209
   Li XL, 2009, INT J BIOCHEM CELL B, V41, P1526, DOI 10.1016/j.biocel.2009.01.002
   Lucas GM, 2014, CLIN INFECT DIS, V59, pE96, DOI 10.1093/cid/ciu617
   Luescher-Mattli M., 2003, Current Medicinal Chemistry - Anti-Infective Agents, V2, P219, DOI 10.2174/1568012033483051
   Lundgren D, 2015, NEW ENGL J MED, V373, P795, DOI 10.1056/NEJMoa1506816
   Lyseng-Williamson KA, 2005, DRUGS, V65, P413, DOI 10.2165/00003495-200565030-00006
   Manconia M, 2009, J PHARM PHARMACOL, V61, P423, DOI 10.1211/jpp/61.04.0002
   Manda KR, 2011, FREE RADICAL BIO MED, V50, P801, DOI 10.1016/j.freeradbiomed.2010.12.029
   Mandas A, 2009, J BIOMED BIOTECHNOL, DOI 10.1155/2009/749575
   Mao TK, 2005, J MED FOOD, V8, P27, DOI 10.1089/jmf.2005.8.27
   Marcel AK, 2011, NUTRIENTS, V3, P712, DOI 10.3390/nu3070712
   Margot NA, 2009, JAIDS-J ACQ IMM DEF, V52, P209, DOI 10.1097/QAI.0b013e3181b05f7c
   Marrone G, 2021, NUTRIENTS, V13, DOI 10.3390/nu13030817
   Martin AM, 2004, P NATL ACAD SCI USA, V101, P4180, DOI 10.1073/pnas.0307067101
   Maserati R, 2010, AIDS, V24, P1013, DOI 10.1097/QAD.0b013e328336e962
   Masiá M, 2007, CLIN THER, V29, P1448, DOI 10.1016/j.clinthera.2007.07.025
   McCarty MF, 2007, MED HYPOTHESES, V69, P974, DOI 10.1016/j.mehy.2006.12.069
   McColl DJ, 2011, HIV CLIN TRIALS, V12, P61, DOI 10.1310/hct1202-61
   Miao M, 2020, EXPERT OPIN DRUG MET, V16, P11, DOI 10.1080/17425255.2020.1711884
   Miranda MS, 1998, BRAZ J MED BIOL RES, V31, P1075, DOI 10.1590/S0100-879X1998000800007
   Mohan J, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222112020
   Mondal Debasis, 2004, Cardiovasc Toxicol, V4, P287, DOI 10.1385/CT:4:3:287
   Moss DM, 2014, FRONT PHARMACOL, V5, DOI 10.3389/fphar.2014.00248
   Mugwanya KK, 2017, EXPERT OPIN DRUG SAF, V16, P867, DOI 10.1080/14740338.2017.1338271
   Mujawdiya P.K., 2015, INT J PHAR PHARMA SC, V7, P9
   Nasi M, 2017, CLIN EXP IMMUNOL, V187, P44, DOI 10.1111/cei.12814
   Nasirian F, 2018, DIABET METAB SYND OB, V11, P375, DOI 10.2147/DMSO.S172104
   Nawrocka D, 2017, MAR DRUGS, V15, DOI 10.3390/md15080237
   Ngo-Matip ME, 2015, NUTR J, V14, DOI 10.1186/s12937-015-0058-4
   Ngo-Matip ME, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-191
   Ngondi Judith L, 2006, AIDS Res Ther, V3, P19, DOI 10.1186/1742-6405-3-19
   Nguyen KA, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0150970
   Nyakudya TT, 2020, MOLECULES, V25, DOI 10.3390/molecules25112669
   Opie LH, 2007, CIRCULATION, V115, pE32, DOI 10.1161/CIRCULATIONAHA.106.671057
   Oriquat GA, 2019, APPL PHYSIOL NUTR ME, V44, P357, DOI 10.1139/apnm-2018-0354
   Palios J, 2012, EXP DIABETES RES, DOI 10.1155/2012/103063
   Patel A, 2006, INDIAN J BIOCHEM BIO, V43, P25
   Patel Ketan K, 2010, Indian J Sex Transm Dis AIDS, V31, P30, DOI 10.4103/0253-7184.68998
   Pelizer LH, 2003, J FOOD ENG, V56, P371, DOI 10.1016/S0260-8774(02)00209-1
   Perez-Torres Israel, 2013, Cardiovascular & Hematological Agents in Medicinal Chemistry, V11, P25
   Pina-Perez M C., 2019, The Role of Alternative and Innovative Food Ingredients and Products in Consumer Wellness, P103, DOI [DOI 10.1016/B978-0-12-816453-2.00004-8, 10.1016/B978-0-12-816453-2.00004-8]
   Pinti M., 2010, Journal of Experimental and Clinical Medicine, V2, P145
   Piovan A, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.724993
   Post FA, 2010, JAIDS-J ACQ IMM DEF, V55, P49, DOI 10.1097/QAI.0b013e3181dd911e
   Rackal JM, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003938.pub2
   Rakhmanina NY, 2012, THERAPEUTIC DRUG MONITORING: NEWER DRUGS AND BIOMARKERS, P373, DOI 10.1016/B978-0-12-385467-4.00017-8
   Release S, 2021, MID POP EST 2021
   Remirez D, 2002, MEDIAT INFLAMM, V11, P81, DOI 10.1080/09629350220131926
   Remirez D, 2002, INFLAMM RES, V51, P351, DOI 10.1007/PL00000314
   Riss J, 2007, J AGR FOOD CHEM, V55, P7962, DOI 10.1021/jf070529g
   Robbins GK, 2003, NEW ENGL J MED, V349, P2293, DOI 10.1056/NEJMoa030264
   Rogalska-Plonska M, 2018, KARDIOL POL, V76, P548, DOI 10.5603/KP.a2017.0249
   Romay C, 1998, INFLAMM RES, V47, P334, DOI 10.1007/s000110050338
   Romay C, 1998, INFLAMM RES, V47, P36, DOI 10.1007/s000110050256
   Romay C, 2003, CURR PROTEIN PEPT SC, V4, P207, DOI 10.2174/1389203033487216
   Romay C, 2001, ARZNEIMITTEL-FORSCH, V51, P733
   Saag MS, 2018, JAMA-J AM MED ASSOC, V320, P379, DOI 10.1001/jama.2018.8431
   Sadek KM, 2017, BIOMED PHARMACOTHER, V92, P1085, DOI 10.1016/j.biopha.2017.06.023
   Sax PE, 2009, NEW ENGL J MED, V361, P2230, DOI 10.1056/NEJMoa0906768
   Schafer FQ, 2002, BIOL CHEM, V383, P671, DOI 10.1515/BC.2002.069
   Schafer JJ, 2010, ANN PHARMACOTHER, V44, P145, DOI 10.1345/aph.1M309
   SCHINAZI RF, 1992, ANTIMICROB AGENTS CH, V36, P2423, DOI 10.1128/AAC.36.11.2423
   SCHINAZI RF, 1993, ANTIMICROB AGENTS CH, V37, P875, DOI 10.1128/AAC.37.4.875
   Serban MC, 2016, CLIN NUTR, V35, P842, DOI 10.1016/j.clnu.2015.09.007
   Shafer RW, 1999, BIOMED PHARMACOTHER, V53, P73, DOI 10.1016/S0753-3322(99)80063-8
   Shafi T, 2011, CLIN NEPHROL, V75, pS60, DOI 10.5414/CN106469
   Sharma B., 2011, NEUROBEHAV HIV MED, V3, P27, DOI [10.2147/NBHIV.S11748, DOI 10.2147/NBHIV.S11748]
   Shih CM, 2009, ANESTH ANALG, V108, P1303, DOI 10.1213/ane.0b013e318193e919
   Sliwa K, 2010, EUR J HEART FAIL, V12, P767, DOI 10.1093/eurjhf/hfq120
   So-Armah K, 2018, CURR HIV-AIDS REP, V15, P233, DOI 10.1007/s11904-018-0400-5
   Soliman EZ, 2011, AIDS, V25, P367, DOI 10.1097/QAD.0b013e328341dcc0
   Spinner CD, 2016, INFECTION, V44, P151, DOI 10.1007/s15010-015-0850-2
   Strasky Z, 2013, FOOD FUNCT, V4, P1586, DOI 10.1039/c3fo60230c
   Sun JY, 2019, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01907
   Thompson MA, 2012, JAMA-J AM MED ASSOC, V308, P387, DOI 10.1001/jama.2012.7961
   Turner S, 1997, PLANT SYST EVOL, P13
   Uddin A. J., 2018, INT J BUS SOC SCI RE, V6, P51
   UNAIDS, HIV AIDS EST
   Venhoff N, 2007, ANTIVIR THER, V12, P1075
   Lima FAV, 2017, NEUROCHEM RES, V42, P3390, DOI 10.1007/s11064-017-2379-5
   Vonshak A., 1997, SPIRULINA PLATENSIS
   Wang XW, 2009, LAB INVEST, V89, P1355, DOI 10.1038/labinvest.2009.85
   Whitton B.A., 1992, Diversity, ecology, and taxonomy of the cyanobacteria Photosynthetic prokaryotes, P1
   Winter FS, 2014, NUTRIENTS, V6, P2973, DOI 10.3390/nu6072973
   Wu QH, 2016, ARCH TOXICOL, V90, P1817, DOI 10.1007/s00204-016-1744-5
   Yeligar S.M, 2015, C55 HIV ASS LUNG DIS, pA4720
   Yeni P, 2006, J HEPATOL, V44, pS100, DOI 10.1016/j.jhep.2005.11.021
   Zash R, 2018, NEW ENGL J MED, V379, P979, DOI 10.1056/NEJMc1807653
   Zdanowicz MM, 2006, AM J PHARM EDUC, V70, DOI 10.5688/aj7005100
   Zheng J, 2013, AM J PHYSIOL-REG I, V304, pR110, DOI 10.1152/ajpregu.00648.2011
NR 190
TC 9
Z9 9
U1 1
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2022
VL 14
IS 15
AR 3076
DI 10.3390/nu14153076
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 3S6KP
UT WOS:000839703600001
PM 35893930
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mi, YS
   Qi, GY
   Gao, YQ
   Li, RN
   Wang, YW
   Li, XY
   Huang, SX
   Liu, XB
AF Mi, Yashi
   Qi, Guoyuan
   Gao, Yuqi
   Li, Runnan
   Wang, Yiwen
   Li, Xingyu
   Huang, Shuxian
   Liu, Xuebo
TI (-)-Epigallocatechin-3-gallate Ameliorates Insulin Resistance and
   Mitochondrial Dysfunction in HepG2 Cells: Involvement of Bmal1
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE circadian clock; (-)-epigallocatechin-3-gallate; insulin resistance;
   mitochondrial function; oxidative stress
ID HIGH-FAT DIET; INDUCED OXIDATIVE STRESS; GREEN TEA POLYPHENOL; METABOLIC
   SYNDROME; CIRCADIAN-RHYTHMS; LIVER-DISEASE; GLUCOSE-HOMEOSTASIS;
   ABDOMINAL OBESITY; CANCER-CELLS; MICE
AB Scope Normal physiological processes require a robust biological timer called the circadian clock. Dysregulation of circadian rhythms contributes to a variety of metabolic syndrome, including obesity and insulin resistance. (-)-Epigallocatechin-3-gallate (EGCG) has been demonstrated to possess antioxidant, anti-inflammatory, and cardioprotective bioactivities. The objective of this study was to explore whether the circadian clock is involved in the protective effect of EGCG against insulin resistance.
   Methods and results The results demonstrated that EGCG reverses the relatively shallow daily oscillations of circadian clock genes transcription and protein expression induced by glucosamine in HepG2 cells. EGCG also alleviates insulin resistance by enhancing tyrosine phosphorylated levels of IRS-1, stimulating the translocation of GLUT2, and activating PI3K/AKT as well as AMPK signaling pathways in a Bmal1-dependent manner both in HepG2 cells and primary hepatocytes. Glucosamine-stimulated excessive secretions of ROS and depletions of mitochondrial membrane potential were notably attenuated in EGCG co-treated HepG2 cells, which consistent with the recovery in expression of mitochondrial respiration complexes.
   Conclusion The results demonstrated that EGCG possesses a Bmal1-dependent efficacy against insulin resistance conditions by strengthening the insulin signaling and eliminating oxidative stress, suggesting that EGCG may serve as a promising natural nutraceutical for the regulation of metabolic disorders relevant to circadian clocks.
C1 [Mi, Yashi; Qi, Guoyuan; Gao, Yuqi; Li, Runnan; Wang, Yiwen; Li, Xingyu; Huang, Shuxian; Liu, Xuebo] Northwest A&F Univ, Coll Food Sci & Engn, Lab Funct Chem & Nutr Food, Yangling, Shaanxi, Peoples R China.
C3 Northwest A&F University - China
RP Liu, XB (corresponding author), Northwest A&F Univ, Coll Food Sci & Engn, Lab Funct Chem & Nutr Food, Yangling, Shaanxi, Peoples R China.
EM xueboliu@aliyun.com
RI /AAZ-9695-2020
OI Li., Runnan/0009-0007-6655-2325
FU National Natural Science Foundation of China [31571842]; National Key
   Research and Development Program of China [2016YFD0400601]
FX This work was financially supported by the National Natural Science
   Foundation of China (No. 31571842) and the National Key Research and
   Development Program of China (No. 2016YFD0400601).
CR Anderson EJ, 2009, J CLIN INVEST, V119, P573, DOI 10.1172/JCI37048
   Antoch M. P., 2013, CIRCADIAN CLOCKS, P289
   Bailey CJ, 2004, DIABETES OBES METAB, V6, P293, DOI 10.1111/j.1462-8902.2004.00350.x
   Bailey SM, 2014, J ENDOCRINOL, V222, pR75, DOI 10.1530/JOE-14-0200
   Baron KG, 2014, INT REV PSYCHIATR, V26, P139, DOI 10.3109/09540261.2014.911149
   Bose M, 2008, J NUTR, V138, P1677, DOI 10.1093/jn/138.9.1677
   Branecky KL, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0137970
   Buxton OM, 2010, DIABETES, V59, P2126, DOI 10.2337/db09-0699
   Chen Z, 2013, CELL MOL LIFE SCI, V70, P2985, DOI 10.1007/s00018-012-1207-y
   Chen Z, 2012, P NATL ACAD SCI USA, V109, P101, DOI 10.1073/pnas.1118034108
   Cordero-Herrera I, 2015, MOL NUTR FOOD RES, V59, P597, DOI 10.1002/mnfr.201400492
   Cordero-Herrera I, 2013, MOL NUTR FOOD RES, V57, P974, DOI 10.1002/mnfr.201200500
   Cui H., 2011, J. Signal Transduct, V2012
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Drewnowski A, 2007, EPIDEMIOL REV, V29, P160, DOI 10.1093/epirev/mxm011
   Durante PE, 2002, AM J PHYSIOL-ENDOC M, V283, pE178, DOI 10.1152/ajpendo.00404.2001
   Dutta M, 2014, FOOD CHEM TOXICOL, V66, P262, DOI 10.1016/j.fct.2014.01.050
   Eckel-Mahan KL, 2013, CELL, V155, P1464, DOI 10.1016/j.cell.2013.11.034
   Estany S, 2007, J REPROD IMMUNOL, V75, P1, DOI 10.1016/j.jri.2007.01.007
   Froy O, 2007, FRONT NEUROENDOCRIN, V28, P61, DOI 10.1016/j.yfrne.2007.03.001
   Gan L, 2015, ACTA PHARMACOL SIN, V36, P597, DOI 10.1038/aps.2015.11
   Green CB, 2008, CELL, V134, P728, DOI 10.1016/j.cell.2008.08.022
   Hatori M, 2012, CELL METAB, V15, P848, DOI 10.1016/j.cmet.2012.04.019
   He BK, 2016, CELL METAB, V23, P610, DOI 10.1016/j.cmet.2016.03.007
   Herranz-López M, 2015, PHYTOMEDICINE, V22, P605, DOI 10.1016/j.phymed.2015.03.015
   Huang WY, 2011, J CLIN INVEST, V121, P2133, DOI 10.1172/JCI46043
   Hwang JT, 2007, CANCER LETT, V247, P115, DOI 10.1016/j.canlet.2006.03.030
   Jacobi D, 2015, CELL METAB, V22, P709, DOI 10.1016/j.cmet.2015.08.006
   Leproult R, 2014, DIABETES, V63, P1860, DOI 10.2337/db13-1546
   Li HY, 2016, MOL NUTR FOOD RES, V60, P2565, DOI 10.1002/mnfr.201600162
   Lin CL, 2008, MOL NUTR FOOD RES, V52, P930, DOI 10.1002/mnfr.200700437
   Liu D, 2016, J NUTR BIOCHEM, V28, P164, DOI 10.1016/j.jnutbio.2015.10.003
   Liu J, 2016, ENDOCRINOLOGY, V157, P2259, DOI 10.1210/en.2015-2027
   Liu ZG, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600717
   Marcheva B, 2010, NATURE, V466, P627, DOI 10.1038/nature09253
   Mi YS, 2017, BBA-MOL BASIS DIS, V1863, P1575, DOI 10.1016/j.bbadis.2017.04.009
   Mi YS, 2016, FREE RADICAL BIO MED, V90, P230, DOI 10.1016/j.freeradbiomed.2015.11.022
   Popkin BM, 2012, NUTR REV, V70, P3, DOI 10.1111/j.1753-4887.2011.00456.x
   Qi GY, 2017, J FUNCT FOODS, V34, P168, DOI 10.1016/j.jff.2017.04.031
   Qi GY, 2015, FOOD FUNCT, V6, P2918, DOI 10.1039/c5fo00510h
   Rains JL, 2011, FREE RADICAL BIO MED, V50, P567, DOI 10.1016/j.freeradbiomed.2010.12.006
   Ribas-Latre A, 2015, J NUTR BIOCHEM, V26, P112, DOI 10.1016/j.jnutbio.2014.09.006
   Ritchie SA, 2007, NUTR METAB CARDIOVAS, V17, P319, DOI 10.1016/j.numecd.2006.07.005
   Sadacca LA, 2011, DIABETOLOGIA, V54, P120, DOI 10.1007/s00125-010-1920-8
   Samuel VT, 2012, CELL, V148, P852, DOI 10.1016/j.cell.2012.02.017
   Shi SQ, 2013, CURR BIOL, V23, P372, DOI 10.1016/j.cub.2013.01.048
   Sukumaran S, 2010, ADV DRUG DELIVER REV, V62, P904, DOI 10.1016/j.addr.2010.05.009
   Sun LJ, 2015, BIOCHEM BIOPH RES CO, V458, P86, DOI 10.1016/j.bbrc.2015.01.072
   Suwannaphet W, 2010, FOOD CHEM TOXICOL, V48, P1853, DOI 10.1016/j.fct.2010.04.021
   Tong X, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0130047
   Tseng HL, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0120380
   Utzschneider KM, 2006, J CLIN ENDOCR METAB, V91, P4753, DOI 10.1210/jc.2006-0587
   Vidyashankar S, 2013, TOXICOL IN VITRO, V27, P945, DOI 10.1016/j.tiv.2013.01.014
   Zhang Y, 2012, DIABETES, V61, P1434, DOI 10.2337/db11-0499
   Zhou B, 2014, HEPATOLOGY, V59, P2196, DOI 10.1002/hep.26992
   Zhu D, 2017, RSC ADV, V7, P1363, DOI 10.1039/c6ra25901d
   Zhu D, 2015, J AGR FOOD CHEM, V63, P10903, DOI 10.1021/acs.jafc.5b04533
NR 57
TC 52
Z9 53
U1 4
U2 93
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD DEC
PY 2017
VL 61
IS 12
AR 1700440
DI 10.1002/mnfr.201700440
PG 15
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA FP2PC
UT WOS:000417459400016
PM 28869341
DA 2025-06-11
ER

PT J
AU Nunn, AVW
   Bell, JD
   Guy, GW
AF Nunn, Alistair V. W.
   Bell, Jimmy D.
   Guy, Geoffrey W.
TI Lifestyle-induced metabolic inflexibility and accelerated ageing
   syndrome: insulin resistance, friend or foe?
SO NUTRITION & METABOLISM
LA English
DT Review
ID ACTIVATED PROTEIN-KINASE; NF-KAPPA-B; TRANSCRIPTION FACTOR FOXO1;
   ENDOPLASMIC-RETICULUM STRESS; PROMOTES MITOCHONDRIAL BIOGENESIS;
   POLYUNSATURATED FATTY-ACIDS; HIGH-DENSITY-LIPOPROTEIN; VISCERAL
   ADIPOSE-TISSUE; NITRIC-OXIDE SYNTHASE; ACUTE-PHASE REACTANTS
AB The metabolic syndrome may have its origins in thriftiness, insulin resistance and one of the most ancient of all signalling systems, redox. Thriftiness results from an evolutionarily-driven propensity to minimise energy expenditure. This has to be balanced with the need to resist the oxidative stress from cellular signalling and pathogen resistance, giving rise to something we call 'redox-thriftiness'. This is based on the notion that mitochondria may be able to both amplify membrane-derived redox growth signals as well as negatively regulate them, resulting in an increased ATP/ROS ratio. We suggest that 'redox-thriftiness' leads to insulin resistance, which has the effect of both protecting the individual cell from excessive growth/inflammatory stress, while ensuring energy is channelled to the brain, the immune system, and for storage. We also suggest that fine tuning of redox-thriftiness is achieved by hormetic (mild stress) signals that stimulate mitochondrial biogenesis and resistance to oxidative stress, which improves metabolic flexibility. However, in a non-hormetic environment with excessive calories, the protective nature of this system may lead to escalating insulin resistance and rising oxidative stress due to metabolic inflexibility and mitochondrial overload. Thus, the mitochondrially-associated resistance to oxidative stress (and metabolic flexibility) may determine insulin resistance. Genetically and environmentally determined mitochondrial function may define a 'tipping point' where protective insulin resistance tips over to inflammatory insulin resistance. Many hormetic factors may induce mild mitochondrial stress and biogenesis, including exercise, fasting, temperature extremes, unsaturated fats, polyphenols, alcohol, and even metformin and statins. Without hormesis, a proposed redox-thriftiness tipping point might lead to a feed forward insulin resistance cycle in the presence of excess calories. We therefore suggest that as oxidative stress determines functional longevity, a rather more descriptive term for the metabolic syndrome is the 'lifestyle-induced metabolic inflexibility and accelerated ageing syndrome'. Ultimately, thriftiness is good for us as long as we have hormetic stimuli; unfortunately, mankind is attempting to remove all hormetic (stressful) stimuli from his environment.
C1 [Nunn, Alistair V. W.; Bell, Jimmy D.] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, MRC Clin Sci Ctr, Metab & Mol Imaging Grp, London W12 OHS, England.
   [Guy, Geoffrey W.] GW Pharmaceut, Porton Down, Dorset, England.
C3 Imperial College London
RP Nunn, AVW (corresponding author), Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, MRC Clin Sci Ctr, Metab & Mol Imaging Grp, Du Cane Rd, London W12 OHS, England.
EM alistair.nunn@btconnect.com; jimmy.bell@csc.mrc.ac.uk; gwg@gwpharm.com
RI Nunn, Alistair/ABE-2462-2020
OI Bell, Jimmy/0000-0003-3804-1281
FU MRC [MC_U120061305] Funding Source: UKRI; Medical Research Council
   [MC_U120061305] Funding Source: Medline
CR Accurso A, 2008, NUTR METAB, V5, DOI 10.1186/1743-7075-5-9
   Adler AS, 2007, GENE DEV, V21, P3244, DOI 10.1101/gad.1588507
   Al-Mahroos F, 1998, DIABETES CARE, V21, P936, DOI 10.2337/diacare.21.6.936
   Al-Mahroos F, 1999, J R SOC PROMO HEALTH, V119, P251, DOI 10.1177/146642409911900410
   Alikhani M, 2005, J BIOL CHEM, V280, P12096, DOI 10.1074/jbc.M412171200
   Allard JS, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003211
   Andersson U, 2004, J BIOL CHEM, V279, P12005, DOI 10.1074/jbc.C300557200
   Andrews ZB, 2008, NATURE, V454, P846, DOI 10.1038/nature07181
   Anton S, 2007, CELL SIGNAL, V19, P378, DOI 10.1016/j.cellsig.2006.07.008
   Arany Z, 2008, P NATL ACAD SCI USA, V105, P4721, DOI 10.1073/pnas.0800979105
   Armstrong MB, 2001, AM J PHYSIOL-ENDOC M, V281, pE1197, DOI 10.1152/ajpendo.2001.281.6.E1197
   Athanasiou A, 2007, BIOCHEM BIOPH RES CO, V364, P131, DOI 10.1016/j.bbrc.2007.09.107
   Austenaa LMI, 2004, FASEB J, V18, P1255, DOI 10.1096/fj.03-1098fje
   Bandyopadhyay GK, 2005, DIABETES, V54, P2351, DOI 10.2337/diabetes.54.8.2351
   Bao N, 2007, CIRC J, V71, P1622, DOI 10.1253/circj.71.1622
   Bastie CC, 2004, DIABETES, V53, P2209, DOI 10.2337/diabetes.53.9.2209
   Baur JA, 2006, NATURE, V444, P337, DOI 10.1038/nature05354
   Bell RA, 2000, DIABETES CARE, V23, P1630, DOI 10.2337/diacare.23.11.1630
   Bhatt DL, 2008, AM J CARDIOL, V101, p4D, DOI 10.1016/j.amjcard.2008.02.002
   Björntorp P, 1999, DRUGS, V58, P13
   Blundell JE, 2004, PHYSIOL BEHAV, V82, P21, DOI 10.1016/j.physbeh.2004.04.021
   Bowles JT, 1998, MED HYPOTHESES, V51, P179, DOI 10.1016/S0306-9877(98)90079-2
   Brady NR, 2004, BIOPHYS J, V87, P2022, DOI 10.1529/biophysj.103.035097
   Brett PJ, 2008, CELL MICROBIOL, V10, P487, DOI 10.1111/j.1462-5822.2007.01063.x
   Briviba K, 2002, J NUTR, V132, P2814, DOI 10.1093/jn/132.9.2814
   Brookes PS, 2004, AM J PHYSIOL-CELL PH, V287, pC817, DOI 10.1152/ajpcell.00139.2004
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Bubici C, 2006, ONCOGENE, V25, P6731, DOI 10.1038/sj.onc.1209936
   Bubliy OA, 2005, J EVOLUTION BIOL, V18, P789, DOI 10.1111/j.1420-9101.2005.00928.x
   Büttner S, 2006, J CELL BIOL, V175, P521, DOI 10.1083/jcb.200608098
   Byberg L, 2009, BMJ-BRIT MED J, V338, DOI 10.1136/bmj.b688
   Carroll AM, 2004, BBA-PROTEINS PROTEOM, V1700, P145, DOI 10.1016/j.bbapap.2004.05.008
   Carvalheira JBC, 2005, OBES RES, V13, P48, DOI 10.1038/oby.2005.7
   Choi SL, 2001, BIOCHEM BIOPH RES CO, V287, P92, DOI 10.1006/bbrc.2001.5544
   Cinti S, 2005, J LIPID RES, V46, P2347, DOI 10.1194/jlr.M500294-JLR200
   Civitarese AE, 2007, PLOS MED, V4, P485, DOI 10.1371/journal.pmed.0040076
   Coleman CI, 2008, CURR MED RES OPIN, V24, P1359, DOI [10.1185/030079908X292029, 10.1185/030079908X292029 ]
   Cook SP, 2006, SWISS MED WKLY, V136, P103
   Copeland RJ, 2008, AM J PHYSIOL-ENDOC M, V295, pE17, DOI 10.1152/ajpendo.90281.2008
   Corton JC, 2005, J GERONTOL A-BIOL, V60, P1494, DOI 10.1093/gerona/60.12.1494
   Corton JC, 2004, J BIOL CHEM, V279, P46204, DOI 10.1074/jbc.M406739200
   COSGROVE JP, 1987, LIPIDS, V22, P299, DOI 10.1007/BF02533996
   Cunningham JT, 2007, NATURE, V450, P736, DOI 10.1038/nature06322
   Curioni C, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006162.pub2
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   Dandona Paresh, 2003, Clin Cornerstone, VSuppl 4, pS13
   Dann SG, 2007, TRENDS MOL MED, V13, P252, DOI 10.1016/j.molmed.2007.04.002
   Das SK, 2007, LIFE SCI, V81, P177, DOI 10.1016/j.lfs.2007.05.005
   Daval M, 2006, J PHYSIOL-LONDON, V574, P55, DOI 10.1113/jphysiol.2006.111484
   de la Monte SM, 2008, J GASTROEN HEPATOL, V23, pE477, DOI 10.1111/j.1440-1746.2008.05339.x
   De Souza CT, 2005, ENDOCRINOLOGY, V146, P4192, DOI 10.1210/en.2004-1520
   Delerive P, 1999, J BIOL CHEM, V274, P32048, DOI 10.1074/jbc.274.45.32048
   Demas GE, 2005, P ROY SOC B-BIOL SCI, V272, P1845, DOI 10.1098/rspb.2005.3126
   DI MV, 2008, BRIT J PHARMACOL, V154, P915
   DI MV, 2008, NAT NEUROSCI, V8, P585
   Dowell P, 2003, J BIOL CHEM, V278, P45485, DOI 10.1074/jbc.M309069200
   Doyon C, 2006, DIABETES, V55, P3403, DOI 10.2337/db06-0504
   Du XL, 2003, J CLIN INVEST, V112, P1049, DOI 10.1172/JCI200318127
   Dulloo AG, 2006, HORM RES, V65, P90, DOI 10.1159/000091512
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   Duncan B B, 2001, Sao Paulo Med J, V119, P122
   Eaton SB, 1998, WORLD REV NUTR DIET, V83, P12
   EATON SB, 1992, LIPIDS, V27, P814, DOI 10.1007/BF02535856
   Echtay KS, 2007, FREE RADICAL BIO MED, V43, P1351, DOI 10.1016/j.freeradbiomed.2007.08.011
   Eckardt K, 2009, DIABETOLOGIA, V52, P664, DOI 10.1007/s00125-008-1240-4
   Eikelis N, 2005, EXP PHYSIOL, V90, P673, DOI 10.1113/expphysiol.2005.031385
   Eizirik DL, 2008, ENDOCR REV, V29, P42, DOI 10.1210/er.2007-0015
   Erol A, 2007, BIOESSAYS, V29, P811, DOI 10.1002/bies.20618
   Erusalimsky JD, 2007, ARTERIOSCL THROM VAS, V27, P2524, DOI 10.1161/ATVBAHA.107.151167
   Esposito K, 2008, INT J IMPOT RES, V20, P358, DOI 10.1038/ijir.2008.9
   Essers MAG, 2004, EMBO J, V23, P4802, DOI 10.1038/sj.emboj.7600476
   ESTERBAUER H, 1991, FREE RADICAL BIO MED, V11, P81, DOI 10.1016/0891-5849(91)90192-6
   Esteve E, 2005, CLIN NUTR, V24, P16, DOI 10.1016/j.clnu.2004.08.004
   Evans JL, 2002, ENDOCR REV, V23, P599, DOI 10.1210/er.2001-0039
   Fehm HL, 2006, PROG BRAIN RES, V153, P129, DOI 10.1016/S0079-6123(06)53007-9
   Fernández-Real JM, 1999, DIABETOLOGIA, V42, P1367, DOI 10.1007/s001250051451
   Flanagan DEH, 2000, EUR J CLIN INVEST, V30, P297
   Franks PW, 2005, OBES RES, V13, P1476, DOI 10.1038/oby.2005.178
   FREEDLAND ES, 2004, NUTR METAB, V4, P12
   Frescas D, 2005, J BIOL CHEM, V280, P20589, DOI 10.1074/jbc.M412357200
   Fridlyand LE, 2006, DIABETES OBES METAB, V8, P136, DOI 10.1111/j.1463-1326.2005.00496.x
   Fridlyand LE, 2006, MED HYPOTHESES, V67, P1034, DOI 10.1016/j.mehy.2006.04.057
   Fujita K, 2006, CIRC J, V70, P1437, DOI 10.1253/circj.70.1437
   Fulco M, 2008, CELL CYCLE, V7, P3669, DOI 10.4161/cc.7.23.7164
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Galli S, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002379
   Ghosh S, 2006, FREE RADICAL BIO MED, V41, P1413, DOI 10.1016/j.freeradbiomed.2006.07.021
   Golay A, 2008, INT J OBESITY, V32, P61, DOI 10.1038/sj.ijo.0803695
   Gomes AR, 2008, CELL CYCLE, V7, P3133, DOI 10.4161/cc.7.20.6920
   Goude D, 2002, CLIN SCI, V102, P345, DOI 10.1042/cs1020345
   Greer EL, 2007, J BIOL CHEM, V282, P30107, DOI 10.1074/jbc.M705325200
   Gremlich S, 2005, ENDOCRINOLOGY, V146, P375, DOI 10.1210/en.2004-0667
   Gross DN, 2008, ONCOGENE, V27, P2320, DOI 10.1038/onc.2008.25
   Gu WD, 2008, ANESTHESIOLOGY, V108, P634, DOI 10.1097/ALN.0b013e3181672590
   Guarente L, 2008, CELL, V132, P171, DOI 10.1016/j.cell.2008.01.007
   Guarente L, 2006, NATURE, V444, P868, DOI 10.1038/nature05486
   Güçlü F, 2004, BIOMED PHARMACOTHER, V58, P614, DOI 10.1016/j.biopha.2004.09.005
   Haag M, 2005, MED SCI MONITOR, V11, pRA359
   Hadi HAR, 2005, VASC HEALTH RISK MAN, V1, P183
   HALES CN, 1992, DIABETOLOGIA, V35, P595, DOI 10.1093/ije/dyt133
   Haluzik MM, 2006, ENDOCRINOLOGY, V147, P4517, DOI 10.1210/en.2005-1624
   Han DH, 2004, AM J PHYSIOL-ENDOC M, V286, pE347, DOI 10.1152/ajpendo.00434.2003
   Handschin C, 2008, NATURE, V454, P463, DOI 10.1038/nature07206
   Hanover JA, 2005, P NATL ACAD SCI USA, V102, P11266, DOI 10.1073/pnas.0408771102
   Hansen M, 2008, PLOS GENET, V4, DOI 10.1371/journal.pgen.0040024
   Haussmann MF, 2007, ADV PHYSIOL EDUC, V31, P110, DOI 10.1152/advan.00058.2006
   HEYWOOD PF, 1977, AM J CLIN NUTR, V30, P1726, DOI 10.1093/ajcn/30.10.1726
   Hilakivi-Clarke L, 2005, J NUTR, V135, p2946S, DOI 10.1093/jn/135.12.2946S
   Hirasawa A, 2005, NAT MED, V11, P90, DOI 10.1038/nm1168
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Hotamisligil GS, 2005, DIABETES, V54, pS73, DOI 10.2337/diabetes.54.suppl_2.S73
   Hou WK, 2007, CHINESE MED J-PEKING, V120, P1704, DOI 10.1097/00029330-200710010-00013
   Housley MP, 2008, J BIOL CHEM, V283, P16283, DOI 10.1074/jbc.M802240200
   Howitz KT, 2003, NATURE, V425, P191, DOI 10.1038/nature01960
   Hu FB, 2003, AM J CLIN NUTR, V78, p544S, DOI 10.1093/ajcn/78.3.544S
   Hu MCT, 2004, CELL, V117, P225, DOI 10.1016/S0092-8674(04)00302-2
   Huang HJ, 2007, J CELL SCI, V120, P2479, DOI 10.1242/jcs.001222
   Hudson NJ, 2008, MED HYPOTHESES, V70, P693, DOI 10.1016/j.mehy.2007.05.042
   Incerpi S, 2007, J PHARM PHARMACOL, V59, P1711, DOI 10.1211/jpp.59.12.0014
   Ito E, 2004, BIOCHEM BIOPH RES CO, V324, P810, DOI 10.1016/j.bbrc.2004.08.238
   Jäger S, 2007, P NATL ACAD SCI USA, V104, P12017, DOI 10.1073/pnas.0705070104
   Jbilo O, 2005, FASEB J, V19, P1567, DOI 10.1096/fj.04-3177fje
   Jebb SA, 2006, INT J OBESITY, V30, P1160, DOI 10.1038/sj.ijo.0803194
   Jeong SK, 2008, J KOREAN MED SCI, V23, P789, DOI 10.3346/jkms.2008.23.5.789
   Jiménez C, 2007, J EXP BOT, V58, P1001, DOI 10.1093/jxb/erl260
   Kettawan A, 2007, J CLIN BIOCHEM NUTR, V40, P194, DOI 10.3164/jcbn.40.194
   Khovidhunkit W, 2004, J LIPID RES, V45, P1169, DOI 10.1194/jlr.R300019-JLR200
   Kim JY, 2007, J CLIN INVEST, V117, P2621, DOI 10.1172/JCI31021
   Kim JE, 2004, DIABETES, V53, P2748, DOI 10.2337/diabetes.53.11.2748
   Kitamura T, 2002, J CLIN INVEST, V110, P1839, DOI 10.1172/JCI200216857
   Kitamura T, 2006, NAT MED, V12, P534, DOI 10.1038/nm1392
   Klinge CM, 2005, J BIOL CHEM, V280, P7460, DOI 10.1074/jbc.M411565200
   Kobayashi Tsuneo, 2005, Journal of Smooth Muscle Research, V41, P283, DOI 10.1540/jsmr.41.283
   Kola B, 2005, J BIOL CHEM, V280, P25196, DOI 10.1074/jbc.C500175200
   Kola B, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001797
   Kraegen EW, 2006, AM J PHYSIOL-ENDOC M, V290, pE471, DOI 10.1152/ajpendo.00316.2005
   Kutuk O, 2006, TOXICOL SCI, V90, P120, DOI 10.1093/toxsci/kfj055
   Laferrère B, 2006, J CLIN ENDOCR METAB, V91, P2232, DOI 10.1210/jc.2005-0693
   Lagouge M, 2006, CELL, V127, P1109, DOI 10.1016/j.cell.2006.11.013
   Lai IR, 2008, TRANSPLANTATION, V85, P732, DOI 10.1097/TP.0b013e3181664e70
   Lamming DW, 2004, MOL MICROBIOL, V53, P1003, DOI 10.1111/j.1365-2958.2004.04209.x
   Lane N, 2008, NATURE, V453, P583, DOI 10.1038/453583a
   Lankin VZ, 2007, BIOCHEMISTRY-MOSCOW+, V72, P1081, DOI 10.1134/S0006297907100069
   Lavrovsky Y, 2000, EXP GERONTOL, V35, P521, DOI 10.1016/S0531-5565(00)00118-2
   Lee CH, 2006, P NATL ACAD SCI USA, V103, P3444, DOI 10.1073/pnas.0511253103
   Lee JY, 2006, MOL CELLS, V21, P174
   Lin JD, 2005, CELL, V120, P261, DOI 10.1016/j.cell.2004.11.043
   Lin XY, 2004, J CLIN INVEST, V114, P908, DOI 10.1172/JCI200422217
   Lin Y, 2001, J BIOL CHEM, V276, P42077, DOI 10.1074/jbc.M107101200
   Lin YL, 1997, MOL PHARMACOL, V52, P465, DOI 10.1124/mol.52.3.465
   Linnane AW, 2007, BIOGERONTOLOGY, V8, P445, DOI 10.1007/s10522-007-9096-4
   López-Lluch G, 2006, P NATL ACAD SCI USA, V103, P1768, DOI 10.1073/pnas.0510452103
   Luchsinger JA, 2007, ARCH NEUROL-CHICAGO, V64, P570, DOI 10.1001/archneur.64.4.570
   Ma DWL, 2007, APPL PHYSIOL NUTR ME, V32, P341, DOI 10.1139/H07-036
   Maassen JA, 2007, DIABETOLOGIA, V50, P2036, DOI 10.1007/s00125-007-0776-z
   Malcher-Lopes R, 2008, EUR J PHARMACOL, V583, P322, DOI 10.1016/j.ejphar.2007.12.033
   Marcheselli VL, 2003, J BIOL CHEM, V278, P43807, DOI 10.1074/jbc.M305841200
   Mastrocola R, 2005, J ENDOCRINOL, V187, P37, DOI 10.1677/joe.1.06269
   Mathias S, 1998, BIOCHEM J, V335, P465, DOI 10.1042/bj3350465
   Matsuzawa A, 2008, BBA-GEN SUBJECTS, V1780, P1325, DOI 10.1016/j.bbagen.2007.12.011
   Mechoulam R, 2002, Sci STKE, V2002, pre5, DOI 10.1126/stke.2002.129.re5
   Menon SG, 2007, ONCOGENE, V26, P1101, DOI 10.1038/sj.onc.1209895
   Mercader J, 2006, ENDOCRINOLOGY, V147, P5325, DOI 10.1210/en.2006-0760
   MODI N, 2009, PEDIAT RES IN PRESS
   Mootha VK, 2003, NAT GENET, V34, P267, DOI 10.1038/ng1180
   Morris BJ, 2005, J HYPERTENS, V23, P1285, DOI 10.1097/01.hjh.0000173509.45363.dd
   Motaghedi R, 2008, OBESITY, V16, P1727, DOI 10.1038/oby.2008.309
   Murphy CT, 2003, NATURE, V424, P277, DOI 10.1038/nature01789
   Musaiger AO, 2001, ANN HUM BIOL, V28, P346, DOI 10.1080/030144601300119151
   Muzumdar R, 2008, AGING CELL, V7, P438, DOI 10.1111/j.1474-9726.2008.00391.x
   Nadanaciva S, 2007, TOXICOL APPL PHARM, V223, P277, DOI 10.1016/j.taap.2007.06.003
   Nakae J, 2008, DIABETES, V57, P563, DOI 10.2337/db07-0698
   Nakai J, 2002, NAT GENET, V32, P245, DOI 10.1038/ng890
   Nakamura T, 2008, MOL CELL ENDOCRINOL, V281, P47, DOI 10.1016/j.mce.2007.10.007
   Nakano H, 2006, CELL DEATH DIFFER, V13, P730, DOI 10.1038/sj.cdd.4401830
   Nalam Roopa L, 2008, J Biol, V7, P23, DOI 10.1186/jbiol84
   Narayan KMV, 2007, DIABETES CARE, V30, P1562, DOI 10.2337/dc06-2544
   Narkar VA, 2008, CELL, V134, P405, DOI 10.1016/j.cell.2008.06.051
   Navab M, 2004, J LIPID RES, V45, P993, DOI 10.1194/jlr.R400001-JLR200
   Navarro A, 2007, AM J PHYSIOL-CELL PH, V292, pC670, DOI 10.1152/ajpcell.00213.2006
   NEEL JV, 1962, AM J HUM GENET, V14, P353
   Nemoto S, 2005, J BIOL CHEM, V280, P16456, DOI 10.1074/jbc.M501485200
   Ni YG, 2007, P NATL ACAD SCI USA, V104, P20517, DOI 10.1073/pnas.0610290104
   Niedemhofer LJ, 2008, INT J BIOCHEM CELL B, V40, P176, DOI 10.1016/j.biocel.2007.10.008
   Nisoli E, 2005, SCIENCE, V310, P314, DOI 10.1126/science.1117728
   Nunn Alistair V W, 2007, Nucl Recept, V5, P1
   O'Sullivan SE, 2007, BRIT J PHARMACOL, V152, P576, DOI 10.1038/sj.bjp.0707423
   Oak MH, 2006, BRIT J PHARMACOL, V149, P283, DOI 10.1038/sj.bjp.0706843
   Ochoa JJ, 2007, J GERONTOL A-BIOL, V62, P1211, DOI 10.1093/gerona/62.11.1211
   Oh SW, 2005, P NATL ACAD SCI USA, V102, P4494, DOI 10.1073/pnas.0500749102
   Olsen GS, 2002, AM J PHYSIOL-ENDOC M, V283, pE965, DOI 10.1152/ajpendo.00118.2002
   Packard C, 2002, INT J CLIN PRACT, V56, P761
   Parsons PA, 2007, BIOGERONTOLOGY, V8, P613, DOI 10.1007/s10522-007-9101-y
   Parvinen K, 2005, ACTA BIOTHEOR, V53, P241, DOI 10.1007/s10441-005-2531-5
   Pasquali R, 2008, INT J OBESITY, V32, P1764, DOI 10.1038/ijo.2008.129
   Pickup JC, 1997, DIABETOLOGIA, V40, P1286, DOI 10.1007/s001250050822
   PIETINEN P, 1988, ACTA MED SCAND, P169
   Planavila A, 2005, CARDIOVASC RES, V65, P832, DOI 10.1016/j.cardiores.2004.11.011
   Porte D, 2005, DIABETES, V54, P1264, DOI 10.2337/diabetes.54.5.1264
   Prentice AM, 2003, BMJ-BRIT MED J, V327, P880, DOI 10.1136/bmj.327.7420.880
   PSARRA AM, 2008, BIOCH BIOP IN PRESS
   Ramsey MR, 2006, NAT CELL BIOL, V8, P1213, DOI 10.1038/ncb1106-1213
   Rasbach KA, 2008, J PHARMACOL EXP THER, V325, P536, DOI 10.1124/jpet.107.134882
   Rattan SIS, 2004, MECH AGEING DEV, V125, P285, DOI 10.1016/j.mad.2004.01.006
   RAZMARA A, 2008, J PHARM EXP THER
   Reagan LP, 2007, CURR OPIN PHARMACOL, V7, P633, DOI 10.1016/j.coph.2007.10.012
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Reilly JM, 2000, BIOCHEM BIOPH RES CO, V277, P541, DOI 10.1006/bbrc.2000.3705
   Reznick RM, 2006, J PHYSIOL-LONDON, V574, P33, DOI 10.1113/jphysiol.2006.109512
   Rival Y, 2002, EUR J PHARMACOL, V435, P143, DOI 10.1016/S0014-2999(01)01589-8
   Rivellese AA, 2003, BIOMED PHARMACOTHER, V57, P84, DOI 10.1016/S0753-3322(03)00003-9
   Robert L, 2008, BIOGERONTOLOGY, V9, P119, DOI 10.1007/s10522-007-9122-6
   Robinson Irina, 2006, Endocr Pract, V12, P576
   Rohas LM, 2007, P NATL ACAD SCI USA, V104, P7933, DOI 10.1073/pnas.0702683104
   RORIZ S, 2008, BIOCH BIOP IN PRESS
   Salih DAM, 2008, CURR OPIN CELL BIOL, V20, P126, DOI 10.1016/j.ceb.2008.02.005
   Samuel VT, 2006, DIABETES, V55, P2042, DOI 10.2337/db05-0705
   Sandström ME, 2006, J PHYSIOL-LONDON, V575, P251, DOI 10.1113/jphysiol.2006.110601
   Sasaki J, 2008, CLIN THER, V30, P1089, DOI 10.1016/j.clinthera.2008.05.017
   Schäfer C, 2007, J LIPID RES, V48, P1550, DOI 10.1194/jlr.M600513-JLR200
   Schieke SM, 2006, J BIOL CHEM, V281, P27643, DOI 10.1074/jbc.M603536200
   Schmitz-Peiffer C, 1999, J BIOL CHEM, V274, P24202, DOI 10.1074/jbc.274.34.24202
   Schrauwen P, 2004, DIABETES, V53, P1412, DOI 10.2337/diabetes.53.6.1412
   Schrauwen P, 2002, J EXP BIOL, V205, P2275
   Schulz TJ, 2007, CELL METAB, V6, P280, DOI 10.1016/j.cmet.2007.08.011
   Schwartz MW, 2003, DIABETES, V52, P232, DOI 10.2337/diabetes.52.2.232
   Shao HB, 2008, CR BIOL, V331, P433, DOI 10.1016/j.crvi.2008.03.011
   Shay NF, 2005, ANNU REV NUTR, V25, P297, DOI 10.1146/annurev.nutr.25.050304.092639
   Shi H, 2006, J CLIN INVEST, V116, P3015, DOI 10.1172/JCI28898
   SIMON JA, 1995, AM J EPIDEMIOL, V142, P469, DOI 10.1093/oxfordjournals.aje.a117662
   Singh U, 2008, AM J CARDIOL, V102, P321, DOI 10.1016/j.amjcard.2008.03.057
   Sirikul B, 2006, AM J PHYSIOL-ENDOC M, V291, pE724, DOI 10.1152/ajpendo.00364.2005
   Skerrett P J, 2003, Prev Cardiol, V6, P38, DOI 10.1111/j.1520-037X.2003.00959.x
   Skulachev VP, 1999, BIOCHEMISTRY-MOSCOW+, V64, P1418
   Solinas G, 2007, CELL METAB, V6, P386, DOI 10.1016/j.cmet.2007.09.011
   Spalding KL, 2008, NATURE, V453, P783, DOI 10.1038/nature06902
   Spencer NFL, 1997, INT IMMUNOL, V9, P1581, DOI 10.1093/intimm/9.10.1581
   Sreekumar R, 2007, INDIAN J MED RES, V125, P399
   St-Pierre J, 2006, CELL, V127, P397, DOI 10.1016/j.cell.2006.09.024
   Stein DT, 1997, J CLIN INVEST, V100, P398, DOI 10.1172/JCI119546
   Steinberg GR, 2007, CELL CYCLE, V6, P888, DOI 10.4161/cc.6.8.4135
   Steiner MA, 2008, PSYCHONEUROENDOCRINO, V33, P54, DOI 10.1016/j.psyneuen.2007.09.008
   Stöger R, 2008, BIOESSAYS, V30, P156, DOI 10.1002/bies.20700
   Storlien L, 2004, P NUTR SOC, V63, P363, DOI 10.1079/PNS2004349
   Storozhevykh TP, 2007, BMC NEUROSCI, V8, DOI 10.1186/1471-2202-8-84
   Strazzullo P, 2007, HYPERTENSION, V49, P792, DOI 10.1161/01.HYP.0000259737.43916.42
   Suliman HB, 2007, J CELL SCI, V120, P299, DOI 10.1242/jcs.03318
   Suliman HB, 2004, CARDIOVASC RES, V64, P279, DOI 10.1016/j.cardiores.2004.07.005
   Sullivan PG, 2004, ANN NEUROL, V55, P576, DOI 10.1002/ana.20062
   Sun W, 2006, CIRCULATION, V114, P2655, DOI 10.1161/CIRCULATIONAHA.106.630194
   Suwa M, 2006, J APPL PHYSIOL, V101, P1685, DOI 10.1152/japplphysiol.00255.2006
   Szanto A, 2004, CELL DEATH DIFFER, V11, pS126, DOI 10.1038/sj.cdd.4401533
   Taguchi A, 2008, ANNU REV PHYSIOL, V70, P191, DOI 10.1146/annurev.physiol.70.113006.100533
   Takamura T, 2007, BIOCHEM BIOPH RES CO, V361, P379, DOI 10.1016/j.bbrc.2007.07.006
   Tapia PC, 2006, MED HYPOTHESES, V66, P832, DOI 10.1016/j.mehy.2005.09.009
   Tedesco L, 2008, DIABETES, V57, P2028, DOI 10.2337/db07-1623
   Tham DM, 2002, PHYSIOL GENOMICS, V11, P21, DOI 10.1152/physiolgenomics.00062.2002
   Tsalouhidou S, 2006, J ANIM SCI, V84, P2818, DOI 10.2527/jas.2006-031
   Tuncman G, 2006, P NATL ACAD SCI USA, V103, P10741, DOI 10.1073/pnas.0603509103
   Urayama A, 2008, ENDOCRINOLOGY, V149, P3592, DOI 10.1210/en.2008-0008
   Valenzano DR, 2006, CURR BIOL, V16, P296, DOI 10.1016/j.cub.2005.12.038
   Valerio A, 2006, J CLIN INVEST, V116, P2791, DOI [10.1172/JCI28570, 10.1172/JCI28570.]
   van der Poorten D, 2008, HEPATOLOGY, V48, P449, DOI 10.1002/hep.22350
   VAN LF, 2003, J IMMUNOL, V170, P2932
   Varady KA, 2007, J LIPID RES, V48, P2212, DOI 10.1194/jlr.M700223-JLR200
   Varady KA, 2007, AM J CLIN NUTR, V86, P7, DOI 10.1093/ajcn/86.1.7
   Vellai T, 2009, CELL DEATH DIFFER, V16, P94, DOI 10.1038/cdd.2008.126
   Villegas R, 2004, NUTR METAB CARDIOVAS, V14, P233, DOI 10.1016/S0939-4753(04)80049-8
   Viveros M. P., 2008, Endocrine Metabolic & Immune Disorders-Drug Targets, V8, P220, DOI 10.2174/187153008785700082
   Volek Jeff S, 2005, Nutr Metab (Lond), V2, P31, DOI 10.1186/1743-7075-2-31
   Wahba IM, 2007, CLIN J AM SOC NEPHRO, V2, P550, DOI 10.2215/CJN.04071206
   Wajchenberg BL, 2000, ENDOCR REV, V21, P697, DOI 10.1210/er.21.6.697
   Wallerath T, 2002, CIRCULATION, V106, P1652, DOI 10.1161/01.CIR.0000029925.18593.5C
   Wang CS, 2007, AM J EPIDEMIOL, V166, P196, DOI 10.1093/aje/kwm061
   Wang HQ, 2002, AM J PHYSIOL-ENDOC M, V282, pE1352, DOI 10.1152/ajpendo.00230.2001
   Wang MC, 2005, CELL, V121, P115, DOI 10.1016/j.cell.2005.02.030
   Webb C, 2003, AM NAT, V161, P181, DOI 10.1086/345858
   Weber K, 2002, ENDOCRINOLOGY, V143, P177, DOI 10.1210/en.143.1.177
   Weigert C, 2004, J BIOL CHEM, V279, P23942, DOI 10.1074/jbc.M312692200
   Weinkove D, 2006, BMC BIOL, V4, DOI 10.1186/1741-7007-4-1
   Wijndaele K, 2009, EUR J CLIN NUTR, V63, P421, DOI 10.1038/sj.ejcn.1602944
   Wood JG, 2004, NATURE, V430, P686, DOI 10.1038/nature02789
   Woods SC, 2006, DIABETES, V55, pS114, DOI 10.2337/db06-S015
   Wu CH, 2007, INT J OBESITY, V31, P1384, DOI 10.1038/sj.ijo.0803624
   Xiao H, 2004, EXP BIOL MED, V229, P479, DOI 10.1177/153537020422900605
   Xu HE, 1999, MOL CELL, V3, P397, DOI 10.1016/S1097-2765(00)80467-0
   Ye JM, 2001, DIABETES, V50, P411, DOI 10.2337/diabetes.50.2.411
   Yeh CH, 2001, DIABETES, V50, P1495, DOI 10.2337/diabetes.50.6.1495
   Yin W, 2008, STROKE, V39, P3057, DOI 10.1161/STROKEAHA.108.520114
   Yoon JH, 2005, YONSEI MED J, V46, P585, DOI 10.3349/ymj.2005.46.5.585
   Young SE, 2006, DIABETES CARE, V29, P2688, DOI 10.2337/dc06-0915
   Zang MW, 2006, DIABETES, V55, P2180, DOI 10.2337/db05-1188
   Zhang BX, 2006, AM J PHYSIOL-CELL PH, V290, pC1321, DOI 10.1152/ajpcell.00335.2005
   Zhang JD, 2006, BIOCHEM J, V397, P519, DOI 10.1042/BJ20050977
   Zhang KZ, 2008, NATURE, V454, P455, DOI 10.1038/nature07203
   Zhang Y, 2006, PHYSIOL BEHAV, V88, P249, DOI 10.1016/j.physbeh.2006.05.038
   Zheng JB, 2000, BRIT J PHARMACOL, V130, P1115, DOI 10.1038/sj.bjp.0703397
   Zhou JR, 2007, AM J CLIN NUTR, V86, p817S, DOI 10.1093/ajcn/86.3.817S
   Zimmer A, 1999, P NATL ACAD SCI USA, V96, P5780, DOI 10.1073/pnas.96.10.5780
   Zimmet P, 2005, J ATHEROSCLER THROMB, V12, P295, DOI 10.5551/jat.12.295
   Zomer AWM, 2000, J LIPID RES, V41, P1801
   Zou MH, 2004, J BIOL CHEM, V279, P43940, DOI 10.1074/jbc.M404421200
   2003, WORLD HLTH ORGAN TEC, V916, P149
NR 304
TC 58
Z9 64
U1 0
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD APR 16
PY 2009
VL 6
AR 16
DI 10.1186/1743-7075-6-16
PG 26
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 449IS
UT WOS:000266324700001
PM 19371409
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ekstrand, B
   Scheers, N
   Rasmussen, MK
   Young, JF
   Ross, AB
   Landberg, R
AF Ekstrand, Bo
   Scheers, Nathalie
   Rasmussen, Martin Kroyer
   Young, Jette Feveile
   Ross, Alastair B.
   Landberg, Rikard
TI Brain foods - the role of diet in brain performance and health
SO NUTRITION REVIEWS
LA English
DT Review
DE Brain; diet; signaling; cognition; inflammation; proteostasis;
   epigenetics
ID POLYUNSATURATED FATTY-ACIDS; GREEN TEA POLYPHENOL; LONG-CHAIN
   OMEGA-3-FATTY-ACIDS; MILD COGNITIVE IMPAIRMENT; DIPEPTIDYL-PEPTIDASE IV;
   CENTRAL-NERVOUS-SYSTEM; ALZHEIMERS-DISEASE; VITAMIN-D; AMYLOID-BETA;
   METABOLIC SYNDROME
AB The performance of the human brain is based on an interplay between the inherited genotype and external environmental factors, including diet. Food and nutrition, essential in maintenance of brain performance, also aid in prevention and treatment of mental disorders. Both the overall composition of the human diet and specific dietary components have been shown to have an impact on brain function in various experimental models and epidemiological studies. This narrative review provides an overview of the role of diet in 5 key areas of brain function related to mental health and performance, including: (1) brain development, (2) signaling networks and neurotransmitters in the brain, (3) cognition and memory, (4) the balance between protein formation and degradation, and (5) deteriorative effects due to chronic inflammatory processes. Finally, the role of diet in epigenetic regulation of brain physiology is discussed.
C1 [Ekstrand, Bo; Scheers, Nathalie; Ross, Alastair B.; Landberg, Rikard] Chalmers Univ Technol, Dept Biol & Biol Engn Food & Nutr Sci, Gothenburg, Sweden.
   [Rasmussen, Martin Kroyer; Young, Jette Feveile] Aarhus Univ, Dept Food Sci, Agro Food Pk 48, DK-8200 Aarhus N, Denmark.
   [Ross, Alastair B.] AgResearch, Lincoln, New Zealand.
C3 Chalmers University of Technology; Aarhus University; AgResearch - New
   Zealand
RP Rasmussen, MK (corresponding author), Aarhus Univ, Dept Food Sci, Agro Food Pk 48, DK-8200 Aarhus N, Denmark.
EM Martink.rasmussen@food.au.dk
RI Young, Jette/AET-5065-2022; Rasmussen, Martin/AAE-8454-2019
OI Young, Jette Feveile/0000-0002-8809-9513; Rasmussen, Martin
   Kroyer/0000-0002-1889-2874
CR Abbott NJ, 2010, NEUROBIOL DIS, V37, P13, DOI 10.1016/j.nbd.2009.07.030
   Addicott MA, 2009, HUM BRAIN MAPP, V30, P3102, DOI 10.1002/hbm.20732
   Agustí A, 2018, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00155
   Al-Asmakh M, 2012, GUT MICROBES, V3, P366, DOI 10.4161/gmic.21287
   Alpert JE, 1997, NUTR REV, V55, P145, DOI 10.1111/j.1753-4887.1997.tb06468.x
   Amadio M, 2004, PHARMACOL RES, V50, P111, DOI 10.1016/j.phrs.2004.01.003
   An JY, 2018, SCIENCE, V362, P1270, DOI 10.1126/science.aat6576
   Andreasson K, 2010, BRIT J PHARMACOL, V160, P844, DOI 10.1111/j.1476-5381.2010.00715.x
   Angeloni C, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18112230
   [Anonymous], 2013, INT J INFLAMM
   Arroll MA, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-91
   Bading H, 2013, NAT REV NEUROSCI, V14, P593, DOI 10.1038/nrn3531
   Baj A, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20061482
   Balion C, 2012, NEUROLOGY, V79, P1397, DOI 10.1212/WNL.0b013e31826c197f
   Balogun E, 2003, BIOCHEM J, V371, P887, DOI 10.1042/BJ20021619
   Barter JD, 2018, NEUROSCIENTIST, V24, P516, DOI 10.1177/1073858418780971
   Bedrosian TA, 2018, SCIENCE, V359, P1395, DOI 10.1126/science.aah3378
   Belitskaya-Levy Ilana, 2018, Alzheimers Dement (N Y), V4, P344, DOI 10.1016/j.trci.2018.06.001
   Bent S, 2006, AM J MED, V119, P1005, DOI 10.1016/j.amjmed.2006.02.026
   Benton D, 2008, EUR J NUTR, V47, P25, DOI 10.1007/s00394-008-3003-x
   Berendsen AAM, 2017, J AM MED DIR ASSOC, V18, P427, DOI 10.1016/j.jamda.2016.11.026
   Bishop KS, 2015, NUTRIENTS, V7, P922, DOI 10.3390/nu7020922
   Blasko I, 2004, AGING CELL, V3, P169, DOI 10.1111/j.1474-9728.2004.00101.x
   Bonaz B, 2018, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00049
   Bourassa MW, 2016, NEUROSCI LETT, V625, P56, DOI 10.1016/j.neulet.2016.02.009
   Bourre JM, 2006, J NUTR HEALTH AGING, V10, P386
   Bowman GL, 2013, FRONT AGING NEUROSCI, V5, DOI 10.3389/fnagi.2013.00092
   Boyle NB, 2017, NUTRIENTS, V9, DOI 10.3390/nu9050429
   Braidy N, 2017, CNS NEUROL DISORD-DR, V16, P387, DOI 10.2174/1871527316666170328113309
   Braniste V, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3009759
   Briguglio M, 2018, NUTRIENTS, V10, DOI 10.3390/nu10050591
   Broersen LM, 2013, J ALZHEIMERS DIS, V33, P177, DOI 10.3233/JAD-2012-112039
   Browne D, 2019, CLIN INTERV AGING, V14, P1303, DOI 10.2147/CIA.S186760
   Bruel-Jungerman E, 2007, NEUROSCIENTIST, V13, P492, DOI 10.1177/1073858407302725
   Caberlotto L, 2014, BMC SYST BIOL, V8, DOI 10.1186/1752-0509-8-65
   Calabrese V, 2007, NAT REV NEUROSCI, V8, P766, DOI 10.1038/nrn2214
   Campbell EL, 2004, BIOCHEM PHARMACOL, V68, P1631, DOI 10.1016/j.bcp.2004.07.022
   Carnevale D, 2012, HYPERTENSION, V60, P188, DOI 10.1161/HYPERTENSIONAHA.112.195511
   Carpentieri A, 2012, PHARMACOL RES, V65, P437, DOI 10.1016/j.phrs.2012.01.003
   Casal S., 2015, Coffee in health and disease prevention, P737
   Chen WQ, 2009, BEHAV BRAIN RES, V202, P71, DOI 10.1016/j.bbr.2009.03.017
   Cheng G, 2012, INTERN MED J, V42, P484, DOI 10.1111/j.1445-5994.2012.02758.x
   Choi IY, 2015, AM J CLIN NUTR, V101, P287, DOI 10.3945/ajcn.114.096701
   Choi SW, 2010, ADV NUTR, V1, P8, DOI 10.3945/an.110.1004
   Christakos S, 2011, MOL CELL ENDOCRINOL, V347, P25, DOI 10.1016/j.mce.2011.05.038
   Ciechanover A, 2005, NAT REV MOL CELL BIO, V6, P79, DOI 10.1038/nrm1552
   Clarke R, 2014, AM J CLIN NUTR, V100, P657, DOI 10.3945/ajcn.113.076349
   Codagnone MG, 2019, BIOL PSYCHIAT, V85, P150, DOI 10.1016/j.biopsych.2018.06.014
   Coppedè F, 2010, CURR GENOMICS, V11, P246, DOI 10.2174/138920210791233090
   Croteau E, 2018, J ALZHEIMERS DIS, V64, P551, DOI 10.3233/JAD-180202
   Crowell MD, 2006, AM J GASTROENTEROL, V101, P2848, DOI 10.1111/j.1572-0241.2006.00832.x
   Cui X, 2006, J NEUROSCI RES, V84, P647, DOI 10.1002/jnr.20899
   Cummings J, 2017, J ALZHEIMERS DIS, V55, P1131, DOI 10.3233/JAD-160745
   Das UN, 2008, PROSTAG LEUKOTR ESS, V78, P11, DOI 10.1016/j.plefa.2007.10.006
   Dash S, 2015, CURR OPIN PSYCHIATR, V28, P1, DOI 10.1097/YCO.0000000000000117
   Dauncey MJ, 2013, NUTRIENTS, V5, P887, DOI 10.3390/nu5030887
   de Kloet ER, 2005, NAT REV NEUROSCI, V6, P463, DOI 10.1038/nrn1683
   de Urquiza AM, 2000, SCIENCE, V290, P2140, DOI 10.1126/science.290.5499.2140
   Dei Cas M, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092147
   Delange F, 2001, POSTGRAD MED J, V77, P217, DOI 10.1136/pmj.77.906.217
   Deslandes AC, 2005, BRAZ J MED BIOL RES, V38, P1077, DOI 10.1590/S0100-879X2005000700011
   Di Lorenzo A, 2016, MOL NUTR FOOD RES, V60, P566, DOI 10.1002/mnfr.201500567
   Dickerson F, 2017, BRAIN BEHAV IMMUN, V62, P46, DOI 10.1016/j.bbi.2016.12.010
   Dimpfel W., 2018, Food and Nutrition Sciences, V9, P502, DOI 10.4236/fns.2018.95039
   Dinan TG, 2019, CLIN NUTR, V38, P1995, DOI 10.1016/j.clnu.2018.11.010
   Dinan TG, 2017, PSYCHOSOM MED, V79, P920, DOI 10.1097/PSY.0000000000000519
   Donato F, 2017, SCIENCE, V355, DOI 10.1126/science.aai8178
   Double KL, 2003, BIOCHEM PHARMACOL, V66, P489, DOI 10.1016/S0006-2952(03)00293-4
   Drucker DJ, 2006, LANCET, V368, P1696, DOI 10.1016/S0140-6736(06)69705-5
   Duan L, 2009, J PHYSIOL-LONDON, V587, P4063, DOI 10.1113/jphysiol.2009.174797
   Duraffourd C, 2012, CELL, V150, P377, DOI 10.1016/j.cell.2012.05.039
   Ekstrand B, 2017, FOOD RES INT, V100, P1, DOI 10.1016/j.foodres.2017.08.024
   Elison E, 2016, BRIT J NUTR, V116, P1356, DOI 10.1017/S0007114516003354
   Elsas SM, 2010, PHYTOMEDICINE, V17, P940, DOI 10.1016/j.phymed.2010.03.002
   Eriksson PS, 1998, NAT MED, V4, P1313, DOI 10.1038/3305
   Espeland MA, 2018, J AM GERIATR SOC, V66, P120, DOI 10.1111/jgs.15159
   Eyles DW, 2013, FRONT NEUROENDOCRIN, V34, P47, DOI 10.1016/j.yfrne.2012.07.001
   Fan DW, 2018, NUTRIENTS, V10, DOI 10.3390/nu10060714
   Fardet A, 2010, NUTR RES REV, V23, P65, DOI 10.1017/S0954422410000041
   Farokhnia M, 2013, CLIN NEUROPHARMACOL, V36, P185, DOI 10.1097/WNF.0000000000000001
   Farr SA, 2003, J NEUROCHEM, V84, P1173, DOI 10.1046/j.1471-4159.2003.01580.x
   Díaz-Villanueva JF, 2015, INT J MOL SCI, V16, P17193, DOI 10.3390/ijms160817193
   Firth J, 2019, PSYCHOSOM MED, V81, P265, DOI 10.1097/PSY.0000000000000673
   Fotuhi M, 2009, NAT CLIN PRACT NEURO, V5, P140, DOI 10.1038/ncpneuro1044
   Francis H, 2013, APPETITE, V63, P119, DOI 10.1016/j.appet.2012.12.018
   Frederickson CJ, 2005, NAT REV NEUROSCI, V6, P449, DOI 10.1038/nrn1671
   Freeman MP, 2006, J CLIN PSYCHIAT, V67, P1954, DOI 10.4088/JCP.v67n1217
   Gage FH, 2002, J NEUROSCI, V22, P612, DOI 10.1523/JNEUROSCI.22-03-00612.2002
   Gandal MJ, 2018, SCIENCE, V359, P693, DOI 10.1126/science.aad6469
   Gangwisch JE, 2015, AM J CLIN NUTR, V102, P454, DOI 10.3945/ajcn.114.103846
   Gao Y, 2006, NEUROSCIENCE, V141, P1139, DOI 10.1016/j.neuroscience.2006.04.066
   Gawryluk JW, 2011, INT J NEUROPSYCHOPH, V14, P123, DOI 10.1017/S1461145710000805
   Giles C, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0166964
   Girault JA, 2020, SCIENCE, V368, P134, DOI 10.1126/science.abb3533
   Glade MJ, 2015, NUTRITION, V31, P781, DOI 10.1016/j.nut.2014.10.014
   Global Council on Brain Health, 2019, REAL DEAL BRAIN HLTH
   Global Council on Brain Health, 2018, BRAIN FOOD GCBH RECO
   Gomez-Pinilla F, 2012, NUTR NEUROSCI, V15, P127, DOI 10.1179/1476830511Y.0000000035
   Gower-Winter SD, 2012, BIOFACTORS, V38, P186, DOI 10.1002/biof.1012
   Goyarzu F, 2004, NUTR NEUROSCI, V7, P75, DOI 10.1080/10284150410001710410
   Grabrucker Andreas M, 2011, Drug Deliv Lett, V1, P13
   Greenwood PM, 2010, FRONT AGING NEUROSCI, V2, DOI 10.3389/fnagi.2010.00150
   Grimm MOW, 2011, J BIOL CHEM, V286, P14028, DOI 10.1074/jbc.M110.182329
   Guan J, 2014, SCI REP-UK, V4, DOI 10.1038/srep04388
   Gugliandolo A, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18122504
   Guillermo RB, 2015, FOOD NUTR RES, V59, DOI 10.3402/fnr.v59.25765
   Gulyaeva N, 2012, J NEUROCHEM, V121, P841, DOI 10.1111/j.1471-4159.2012.07708.x
   Guo J, 2015, FRONT AGING NEUROSCI, V7, DOI 10.3389/fnagi.2015.00213
   Gurnida DA, 2012, EARLY HUM DEV, V88, P595, DOI 10.1016/j.earlhumdev.2012.01.003
   Gutierrez-Monreal MA, 2014, J BIOL RHYTHM, V29, P384, DOI 10.1177/0748730414549239
   Hallböök T, 2012, EPILEPSY RES, V100, P304, DOI 10.1016/j.eplepsyres.2011.04.017
   Hammen C, 2005, ANNU REV CLIN PSYCHO, V1, P293, DOI 10.1146/annurev.clinpsy.1.102803.143938
   Hanus LO, 2010, CURR MED CHEM, V17, P1341, DOI 10.2174/092986710790980096
   Harrison FE, 2009, FREE RADICAL BIO MED, V46, P719, DOI 10.1016/j.freeradbiomed.2008.12.018
   Hetz C, 2014, NAT REV NEUROSCI, V15, P233, DOI 10.1038/nrn3689
   Hills RD, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071613
   Hong S, 2016, DEV CELL, V38, P126, DOI 10.1016/j.devcel.2016.07.006
   Iffland K, 2017, CANNABIS CANNABINOID, V2, P139, DOI 10.1089/can.2016.0034
   Inoue R, 2019, J CLIN BIOCHEM NUTR, V64, P217, DOI 10.3164/jcbn.18-105
   Irsfeld M., 2013, WebmedCentral, V4, P4409
   Jack CR, 2010, LANCET NEUROL, V9, P119, DOI 10.1016/S1474-4422(09)70299-6
   Jacka FN, 2017, EBIOMEDICINE, V17, P24, DOI 10.1016/j.ebiom.2017.02.020
   Jacka FN, 2015, BMC MED, V13, DOI 10.1186/s12916-015-0461-x
   Jacka FN, 2010, AM J PSYCHIAT, V167, P305, DOI 10.1176/appi.ajp.2009.09060881
   Jackson MP, 2016, ESSAYS BIOCHEM, V60, P173, DOI 10.1042/EBC20160005
   Joëls M, 2004, STRESS, V7, P221, DOI 10.1080/10253890500070005
   Johnson MB, 2017, FRONT CELL NEUROSCI, V10, DOI 10.3389/fncel.2016.00296
   Johnson RW, 2015, BRAIN BEHAV IMMUN, V43, P1, DOI 10.1016/j.bbi.2014.09.022
   Jones G, 2008, ESSAYS BIOCHEM, V44, P109, DOI 10.1042/BSE0440109
   Jongkees BJ, 2015, J PSYCHIATR RES, V70, P50, DOI 10.1016/j.jpsychires.2015.08.014
   Josselyn SA, 2020, SCIENCE, V367, P39, DOI 10.1126/science.aaw4325
   Kaelberer MM, 2018, SCIENCE, V361, P1219, DOI 10.1126/science.aat5236
   Kanoski SE, 2011, PHYSIOL BEHAV, V103, P59, DOI 10.1016/j.physbeh.2010.12.003
   Kaplan BJ, 2007, PSYCHOL BULL, V133, P747, DOI 10.1037/0033-2909.133.5.747
   Karatayev O, 2009, ALCOHOL, V43, P571, DOI 10.1016/j.alcohol.2009.09.025
   Karnani MM, 2011, NEURON, V72, P616, DOI 10.1016/j.neuron.2011.08.027
   Kaushik S, 2015, NAT MED, V21, P1406, DOI 10.1038/nm.4001
   Kennedy DO, 2016, NUTRIENTS, V8, DOI 10.3390/nu8020068
   Kerek R, 2013, CELL DEATH DIS, V4, DOI 10.1038/cddis.2013.278
   Keunen K, 2015, PEDIATR RES, V77, P148, DOI 10.1038/pr.2014.171
   Khan NA, 2015, J NUTR, V145, P143, DOI 10.3945/jn.114.198457
   Kirchgessner AL, 2002, ENDOCR REV, V23, P1, DOI 10.1210/er.23.1.1
   Kitajka K, 2004, P NATL ACAD SCI USA, V101, P10931, DOI 10.1073/pnas.0402342101
   Klaips CL, 2018, J CELL BIOL, V217, P51, DOI 10.1083/jcb.201709072
   Knüppel A, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-05649-7
   Kodali M, 2015, SCI REP-UK, V5, DOI 10.1038/srep08075
   Kogan Natalya M, 2007, Dialogues Clin Neurosci, V9, P413
   Krishnan V, 2008, NATURE, V455, P894, DOI 10.1038/nature07455
   Lacroix IME, 2016, TRENDS FOOD SCI TECH, V54, P1, DOI 10.1016/j.tifs.2016.05.008
   Ladero V, 2010, CURR NUTR FOOD SCI, V6, P145, DOI 10.2174/157340110791233256
   Lang UE, 2013, CELL PHYSIOL BIOCHEM, V31, P761, DOI 10.1159/000350094
   Langelier B, 2010, J CELL BIOCHEM, V110, P1356, DOI 10.1002/jcb.22652
   Lanni C, 2008, PHARMACOL RES, V57, P196, DOI 10.1016/j.phrs.2008.02.004
   Lardner AL, 2014, NUTR NEUROSCI, V17, P145, DOI 10.1179/1476830513Y.0000000079
   Latour A, 2013, AGING CELL, V12, P76, DOI 10.1111/acel.12026
   Lauriola M, 2018, CURR ALZHEIMER RES, V15, P381, DOI 10.2174/1567205014666171110160556
   Lavoie S, 2008, NEUROPSYCHOPHARMACOL, V33, P2187, DOI 10.1038/sj.npp.1301624
   Layé S, 2018, PHARMACOL REV, V70, P12, DOI 10.1124/pr.117.014092
   Lee JW, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms13123
   Lepack AE, 2020, SCIENCE, V368, P197, DOI 10.1126/science.aaw8806
   Li MF, 2018, SCIENCE, V362, P1264, DOI 10.1126/science.aat7615
   Liang WN, 2016, ARQ NEURO-PSIQUIAT, V74, P482, DOI 10.1590/0004-282X20160065
   Lindbergh CA, 2017, J INT NEUROPSYCH SOC, V23, P11, DOI 10.1017/S1355617716000850
   Liperoti R, 2009, CURR PHARM DESIGN, V15, P4165, DOI 10.2174/138161209789909683
   Liu YJ, 2015, J NEUROGENET, V29, P50, DOI 10.3109/01677063.2015.1067203
   Loboda A, 2016, CELL MOL LIFE SCI, V73, P3221, DOI 10.1007/s00018-016-2223-0
   Lopez A, 2016, LANCET, V387, P907, DOI 10.1016/S0140-6736(15)60865-0
   Lorenzen N, 2014, J BIOL CHEM, V289, P21299, DOI 10.1074/jbc.M114.554667
   Lovinger DM, 2008, ALCOHOL RES HEALTH, V31, P196
   Lozoff B, 2006, NUTR REV, V64, pS34, DOI 10.1301/nr.2006.may.S34-S43
   Lu J, 2007, BIOCHEM PHARMACOL, V74, P1078, DOI 10.1016/j.bcp.2007.07.007
   Lu J, 2010, BRAIN PATHOL, V20, P598, DOI 10.1111/j.1750-3639.2009.00339.x
   Maalouf M, 2009, BRAIN RES REV, V59, P293, DOI 10.1016/j.brainresrev.2008.09.002
   Mandel S, 2004, J NEUROCHEM, V88, P1555, DOI 10.1046/j.1471-4159.2003.02291.x
   Männikkö R, 2015, BRIT J NUTR, V114, P231, DOI 10.1017/S0007114515001890
   Martin B, 2006, AGEING RES REV, V5, P332, DOI 10.1016/j.arr.2006.04.002
   Martín-Sosa S, 2004, LIPIDS, V39, P111, DOI 10.1007/s11745-004-1208-4
   Mattei D, 2019, CURR NUTR REP, V8, P99, DOI 10.1007/s13668-019-0268-z
   McEvoy CT, 2017, J AM GERIATR SOC, V65, P1857, DOI 10.1111/jgs.14922
   McGowan PO, 2008, BRAIN RES, V1237, P12, DOI 10.1016/j.brainres.2008.07.074
   Mechoulam R, 2013, ANNU REV PSYCHOL, V64, P21, DOI 10.1146/annurev-psych-113011-143739
   Meng X, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040367
   Mergenthaler P, 2013, TRENDS NEUROSCI, V36, P587, DOI 10.1016/j.tins.2013.07.001
   Mi WQ, 2013, NUTRITION, V29, P1080, DOI 10.1016/j.nut.2013.01.024
   Miodownik C, 2011, CLIN NEUROPHARMACOL, V34, P155, DOI 10.1097/WNF.0b013e318220d8c6
   Moretti R, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20010231
   Morris MC, 2015, ALZHEIMERS DEMENT, V11, P1015, DOI 10.1016/j.jalz.2015.04.011
   Müller T, 2015, DRUGS, V75, P157, DOI 10.1007/s40265-014-0343-0
   Murphy T, 2014, NEURAL PLAST, V2014, DOI 10.1155/2014/563160
   Nabavi SF, 2016, PHYTOTHER RES, V30, P532, DOI 10.1002/ptr.5569
   Nabavi SM, 2017, NUTR NEUROSCI, V20, P180, DOI 10.1080/1028415X.2015.1103461
   Nelson TJ, 2017, J ALZHEIMERS DIS, V58, P521, DOI 10.3233/JAD-170161
   Nepal B, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0099305
   Neuhaus W, 2008, PLANTA MED, V74, P1338, DOI 10.1055/s-2008-1081343
   Ngan A, 2011, PHYTOTHER RES, V25, P1153, DOI 10.1002/ptr.3400
   Nortley R, 2019, SCIENCE, V365, P250, DOI 10.1126/science.aav9518
   Nourhashemi F, 2018, ALZHEIMERS RES THER, V10, DOI 10.1186/s13195-018-0371-1
   Nurk E, 2009, J NUTR, V139, P120, DOI 10.3945/jn.108.095182
   Nyaradi A, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00097
   Olson CR, 2010, MOL NUTR FOOD RES, V54, P489, DOI 10.1002/mnfr.200900246
   Ozarowski M, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/9729818
   Palazidou E, 2012, BRIT MED BULL, V101, P127, DOI 10.1093/bmb/lds004
   Palmano K, 2015, NUTRIENTS, V7, P3891, DOI 10.3390/nu7053891
   Panduro A, 2017, WORLD J GASTROENTERO, V23, P3030, DOI 10.3748/wjg.v23.i17.3030
   Panza F, 2015, J NUTR HEALTH AGING, V19, P313, DOI 10.1007/s12603-014-0563-8
   Paolicelli RC, 2011, SCIENCE, V333, P1456, DOI 10.1126/science.1202529
   Parker KJ, 2003, HORM BEHAV, V43, P60, DOI 10.1016/S0018-506X(02)00016-8
   Passani MB, 2014, FRONT SYST NEUROSCI, V8, DOI 10.3389/fnsys.2014.00064
   Patocka J, 2010, J APPL BIOMED, V8, P11, DOI 10.2478/v10136-009-0002-z
   Paul A, 2017, SCIENCE, V356, P1383, DOI 10.1126/science.aal3839
   Payne ME, 2008, NUTR RES, V28, P285, DOI 10.1016/j.nutres.2008.02.013
   Peet M, 2004, BRIT J PSYCHIAT, V184, P404, DOI 10.1192/bjp.184.5.404
   Penner MR, 2010, FRONT AGING NEUROSCI, V2, DOI 10.3389/fnagi.2010.00009
   Perez-Pardo P, 2017, FRONT AGING NEUROSCI, V9, DOI 10.3389/fnagi.2017.00057
   Perluigi M, 2006, J NEUROSCI RES, V84, P418, DOI 10.1002/jnr.20879
   Peuhkuri K, 2012, FOOD NUTR RES, V56, DOI 10.3402/fnr.v56i0.17252
   Pilz GA, 2018, SCIENCE, V359, P658, DOI 10.1126/science.aao5056
   Pintér E, 2014, BRIT J CLIN PHARMACO, V77, P5, DOI 10.1111/bcp.12097
   Piomelli D, 2007, NAT REV NEUROSCI, V8, P743, DOI 10.1038/nrn2233
   Piomelli D, 2014, J NEUROSCI, V34, P15184, DOI 10.1523/JNEUROSCI.3475-14.2014
   Piomelli D, 2014, NAT NEUROSCI, V17, P164, DOI 10.1038/nn.3612
   Prado EL, 2014, NUTR REV, V72, P267, DOI 10.1111/nure.12102
   Prehn K, 2017, CEREB CORTEX, V27, P1765, DOI 10.1093/cercor/bhw008
   Pupovac J, 2002, J NUTR, V132, P2775, DOI 10.1093/jn/132.9.2775
   Rabassa M, 2015, J AM GERIATR SOC, V63, P938, DOI 10.1111/jgs.13379
   Rafati A, 2013, FOLIA NEUROPATHOL, V51, P214, DOI 10.5114/fn.2013.37705
   Rajarajan P, 2018, SCIENCE, V362, P1269, DOI 10.1126/science.aat4311
   Rebello CJ, 2015, BBA CLIN, V3, P123, DOI 10.1016/j.bbacli.2015.01.001
   Rehnmark A, 2012, J EXP NEUROSCI, V6, P21, DOI 10.4137/JEN.S10424
   Reichelt AC, 2018, PHYSIOL BEHAV, V192, P118, DOI 10.1016/j.physbeh.2018.02.052
   Reiter R.J., 2006, Ann. N. Y. Acad. Sci, V939, P200, DOI [DOI 10.1111/J.1749-6632.2001.TB03627.X, 10.1111/j.1749-6632.2001.tb03627.x]
   Rendeiro C, 2012, PSYCHOPHARMACOLOGY, V223, P319, DOI 10.1007/s00213-012-2719-8
   Ribeiro JA, 2010, J ALZHEIMERS DIS, V20, pS3, DOI 10.3233/JAD-2010-1379
   Rice HC, 2019, SCIENCE, V363, P143, DOI 10.1126/science.aao4827
   Ritsner MS, 2011, J CLIN PSYCHIAT, V72, P34, DOI 10.4088/JCP.09m05324gre
   Robson LG, 2010, NEUROBIOL AGING, V31, P678, DOI 10.1016/j.neurobiolaging.2008.05.027
   Roca M, 2016, BMC PSYCHIATRY, V16, DOI 10.1186/s12888-016-0900-z
   Rodriguez-Mateos A, 2014, ARCH TOXICOL, V88, P1803, DOI 10.1007/s00204-014-1330-7
   Roh E, 2016, EXP MOL MED, V48, DOI 10.1038/emm.2016.4
   Romeo L, 2009, J AM COLL NUTR, V28, p492S, DOI 10.1080/07315724.2009.10718116
   Rosenzweig ES, 2003, PROG NEUROBIOL, V69, P143, DOI 10.1016/S0301-0082(02)00126-0
   Ross BM, 2009, PROSTAG LEUKOTR ESS, V81, P309, DOI 10.1016/j.plefa.2009.10.004
   Russo A, 2002, FITOTERAPIA, V73, pS21, DOI 10.1016/S0367-326X(02)00187-9
   Salminen A, 2011, J NEUROCHEM, V118, P460, DOI 10.1111/j.1471-4159.2011.07331.x
   Sánchez-Villegas A, 2018, EUR J NUTR, V57, P2409, DOI 10.1007/s00394-017-1514-z
   Sandi C, 2006, NEUROBIOL AGING, V27, P128, DOI 10.1016/j.neurobiolaging.2005.01.006
   Sarris J, 2015, LANCET PSYCHIAT, V2, P271, DOI 10.1016/S2215-0366(14)00051-0
   Scapagnini G, 2004, ANTIOXID REDOX SIGN, V6, P811, DOI 10.1089/1523086041798079
   Scapagnini G, 2002, MOL PHARMACOL, V61, P554, DOI 10.1124/mol.61.3.554
   Scapagnini G, 2006, ANTIOXID REDOX SIGN, V8, P395, DOI 10.1089/ars.2006.8.395
   Scapagnini G, 2011, MOL NEUROBIOL, V44, P192, DOI 10.1007/s12035-011-8181-5
   Schnaar RL, 2014, PHYSIOL REV, V94, P461, DOI 10.1152/physrev.00033.2013
   Scholey A, 2014, NUTRIENTS, V6, P4805, DOI 10.3390/nu6114805
   Shi Y, 2014, CURR NEUROPHARMACOL, V12, P289, DOI 10.2174/1570159X11666131227001243
   Slutsky I, 2010, NEURON, V65, P165, DOI 10.1016/j.neuron.2009.12.026
   Small GW, 2018, AM J GERIAT PSYCHIAT, V26, P266, DOI 10.1016/j.jagp.2017.10.010
   Smith A, 2003, J PSYCHOPHARMACOL, V17, P283, DOI 10.1177/02698811030173010
   Smith AD, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012244
   Sofi F, 2010, AM J CLIN NUTR, V92, P1189, DOI 10.3945/ajcn.2010.29673
   Solfrizzi V, 2010, AGEING RES REV, V9, P184, DOI 10.1016/j.arr.2009.07.005
   Spencer JPE, 2010, BRIT J NUTR, V104, pS40, DOI 10.1017/S0007114510003934
   Spencer SJ, 2017, NPJ SCI FOOD, V1, DOI 10.1038/s41538-017-0008-y
   Srivastava JK, 2010, MOL MED REP, V3, P895, DOI 10.3892/mmr.2010.377
   St-Laurent-Thibault C, 2011, CURR ALZHEIMER RES, V8, P543, DOI 10.2174/156720511796391845
   Stevenson RJ, 2020, ROY SOC OPEN SCI, V7, DOI 10.1098/rsos.191338
   Strandwitz P, 2018, BRAIN RES, V1693, P128, DOI 10.1016/j.brainres.2018.03.015
   Su HM, 2010, J NUTR BIOCHEM, V21, P364, DOI 10.1016/j.jnutbio.2009.11.003
   Swaab DF, 2005, AGEING RES REV, V4, P141, DOI 10.1016/j.arr.2005.03.003
   Sydenham E, 2012, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD005379.pub3, 10.1590/S1516-31802012000600013]
   Takei Y, 2019, HUM CELL, V32, P88, DOI 10.1007/s13577-019-00241-9
   Tang MM, 2016, LIPIDS HEALTH DIS, V15, DOI 10.1186/s12944-016-0236-1
   Tavender TJ, 2010, J CELL SCI, V123, P2672, DOI 10.1242/jcs.067843
   Teschemacher H, 2003, CURR PHARM DESIGN, V9, P1331, DOI 10.2174/1381612033454856
   Thakkar MM, 2011, SLEEP MED REV, V15, P65, DOI 10.1016/j.smrv.2010.06.004
   Tiffon C, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19113425
   Todeschini AR, 2008, BBA-GEN SUBJECTS, V1780, P421, DOI 10.1016/j.bbagen.2007.10.008
   Trebatická J, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/248529
   Uusitupa M, 2013, J INTERN MED, V274, P52, DOI 10.1111/joim.12044
   van der Borght K, 2011, REGUL PEPTIDES, V167, P26, DOI 10.1016/j.regpep.2010.11.002
   Vanlandewijck M, 2018, NATURE, V554, P475, DOI 10.1038/nature25739
   Vauzour D, 2017, AGEING RES REV, V35, P222, DOI 10.1016/j.arr.2016.09.010
   Vauzour D, 2012, OXID MED CELL LONGEV, V2012, DOI 10.1155/2012/914273
   Velarde-Salcedo AJ, 2013, FOOD CHEM, V136, P758, DOI 10.1016/j.foodchem.2012.08.032
   Vermiglio F, 2004, J CLIN ENDOCR METAB, V89, P6054, DOI 10.1210/jc.2004-0571
   Vidal RL, 2014, TRENDS PHARMACOL SCI, V35, P39, DOI 10.1016/j.tips.2014.09.002
   Vignes M, 2006, BRAIN RES, V1110, P102, DOI 10.1016/j.brainres.2006.06.062
   Virel A, 2015, EUR J NEUROSCI, V42, P2761, DOI 10.1111/ejn.13044
   Virgili F, 2008, FREE RADICAL BIO MED, V45, P1205, DOI 10.1016/j.freeradbiomed.2008.08.001
   Wang B, 2012, ADV NUTR, V3, p465S, DOI 10.3945/an.112.001875
   Wang DF, 2018, SCIENCE, V362, DOI 10.1126/science.aat8464
   Wang J, 2013, MOL NUTR FOOD RES, V57, P2091, DOI 10.1002/mnfr.201300230
   Wang J, 2012, J NEUROSCI, V32, P5144, DOI 10.1523/JNEUROSCI.6437-11.2012
   Wang X, 2019, J ALZHEIMERS DIS, V68, P33, DOI 10.3233/JAD-181043
   Wei HF, 2005, BEHAV BRAIN RES, V157, P245, DOI 10.1016/j.bbr.2004.07.003
   Werner T, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-23850-0
   Willcox DC, 2009, J AM COLL NUTR, V28, p500S, DOI 10.1080/07315724.2009.10718117
   Williams CM, 2008, FREE RADICAL BIO MED, V45, P295, DOI 10.1016/j.freeradbiomed.2008.04.008
   Williams S, 2016, SYNAPSE, V70, P121, DOI 10.1002/syn.21880
   Williard DE, 2001, J LIPID RES, V42, P1368
   Witte AV, 2014, CEREB CORTEX, V24, P3059, DOI 10.1093/cercor/bht163
   Wu C, 2015, METAB BRAIN DIS, V30, P367, DOI 10.1007/s11011-014-9560-1
   Xu Y, 2010, EUR NEUROPSYCHOPHARM, V20, P405, DOI 10.1016/j.euroneuro.2010.02.013
   Yaffe K, 2004, JAMA-J AM MED ASSOC, V292, P2237, DOI 10.1001/jama.292.18.2237
   Yamamoto A, 2002, CHEM PHARM BULL, V50, P47, DOI 10.1248/cpb.50.47
   Yang FS, 2005, J BIOL CHEM, V280, P5892, DOI 10.1074/jbc.M404751200
   Yin F, 2013, BIOCHEM SOC T, V41, P101, DOI 10.1042/BST20120260
   Yoo BC, 2001, BIOCHEM BIOPH RES CO, V280, P249, DOI 10.1006/bbrc.2000.4109
   Young SN, 2007, J PSYCHIATR NEUROSCI, V32, P394
   Zecca L, 2004, NAT REV NEUROSCI, V5, P863, DOI 10.1038/nrn1537
   Zhang CG, 2007, ANN NUTR METAB, V51, P379, DOI 10.1159/000107687
   Zhang Q, 2005, NEUROL RES, V27, P552, DOI 10.1179/016164105X25126
   Zhao J, 2007, J NEUROSCI, V27, P10240, DOI 10.1523/JNEUROSCI.1683-07.2007
NR 312
TC 32
Z9 32
U1 4
U2 56
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD JUN
PY 2021
VL 79
IS 6
BP 693
EP 708
DI 10.1093/nutrit/nuaa091
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA SS1WS
UT WOS:000661533900004
PM 32989449
DA 2025-06-11
ER

PT J
AU Badescu, GM
   Fîlfan, M
   Ciobanu, O
   Dumbrava, DA
   Popa-Wagner, A
AF Badescu, George Mihai
   Filfan, Madalina
   Ciobanu, Ovidiu
   Dumbrava, Danut-Adrian
   Popa-Wagner, Aurel
TI Age-related hypoxia in CNS pathology
SO ROMANIAN JOURNAL OF MORPHOLOGY AND EMBRYOLOGY
LA English
DT Review
DE cerebral ischemia; depression; cognition; post-stroke dementia
ID C-REACTIVE PROTEIN; BODY-MASS INDEX; INCREASED CYTOKINE PRODUCTION;
   MAJOR DEPRESSIVE DISORDER; LATE-LIFE DEPRESSION; ADIPOSE-TISSUE;
   INFLAMMATORY RESPONSE; METABOLIC SYNDROME; CEREBRAL HYPOPERFUSION;
   COGNITIVE IMPAIRMENT
AB Although neuropathological conditions differ in the etiology of the inflammatory response, cellular and molecular mechanisms of neuro-inflammation are probably similar in aging, hypertension, depression and cognitive impairment. Moreover, a number of common risk factors such as obesity, hypertension, diabetes and atherosclerosis are increasingly understood to act as "silent contributors" to neuroinflammation and can underlie the development of disorders such as cerebral small vessel disease (cSVD) and subsequent dementia. On the other hand, acute neuroinflammation, such as in response to traumatic or cerebral ischemia, aggravates the acute damage and can lead to a number of pathological such as depression, post-stroke dementia and potentially neurodegeneration. All of those sequelae impair recovery and most of them provide the ground for further cerebrovascular events and a vicious cycle develops. Therefore, understanding the mechanisms associated with vascular dementia, stroke and related complications is of paramount importance in improving current preventive and therapeutic interventions. Likewise, understanding of molecular factors and pathways associated with neuroinflammation will eventually enable the discovery and implementation of new diagnostic and therapeutic strategies indicated in a wide range of neurological conditions.
C1 [Badescu, George Mihai] Univ Med & Pharm Craiova, Psychiat Clin Hosp 2, Craiova, Romania.
   [Filfan, Madalina; Ciobanu, Ovidiu; Dumbrava, Danut-Adrian; Popa-Wagner, Aurel] Univ Med & Pharm Craiova, Ctr Clin & Expt Med, Dept Funct Sci, Craiova, Romania.
   [Popa-Wagner, Aurel] Univ Med Rostock, Dept Psychiat, Gehlsheimer Str 20, D-18147 Rostock, Germany.
C3 University of Medicine & Pharmacy of Craiova; University of Medicine &
   Pharmacy of Craiova; University of Rostock
RP Popa-Wagner, A (corresponding author), Univ Med Rostock, Dept Psychiat, Gehlsheimer Str 20, D-18147 Rostock, Germany.
EM aurel.popa-wagner@med.uni-rostock.de
RI Filfan/Aldea, Madalina/AAG-2450-2021; Popa-Wagner, Aurel/E-2541-2013;
   Dumbrava, Danut-Adrian/L-2816-2018
OI Popa-Wagner, Aurel/0000-0003-4574-8605; Dumbrava,
   Danut-Adrian/0000-0003-4208-4452; Aldea/Filfan,
   Madalina/0000-0003-0543-3596
CR Alexopoulos GS, 2006, BIOL PSYCHIAT, V60, P1304, DOI 10.1016/j.biopsych.2006.09.006
   Allison DJ, 2014, J NEUROINFLAMM, V11, DOI 10.1186/s12974-014-0151-1
   Anand SS, 2013, DIABETES CARE, V36, P2836, DOI 10.2337/dc12-2553
   Andersen KK, 2013, J STROKE CEREBROVASC, V22, pE576, DOI 10.1016/j.jstrokecerebrovasdis.2013.06.031
   Androsova LV, 2013, ZH NEVROL PSIKHIATR, V113, P49
   [Anonymous], CRISIS
   [Anonymous], J CLIN HYPERTENS GRE
   [Anonymous], BRAIN BEHAV IMMUN
   [Anonymous], BRAIN STIMUL
   Badan I, 2003, J CEREBR BLOOD F MET, V23, P845, DOI 10.1097/01.WCB.0000071883.63724.A7
   Barrientos RM, 2015, NEUROSCIENCE, V309, P84, DOI 10.1016/j.neuroscience.2015.03.007
   Bartsch T, 2015, NEUROSCIENCE, V309, P1, DOI 10.1016/j.neuroscience.2015.07.084
   Bauer LO, 2008, PSYCHOPHYSIOLOGY, V45, P1055, DOI 10.1111/j.1469-8986.2008.00706.x
   Baune BT, 2012, PSYCHONEUROENDOCRINO, V37, P1521, DOI 10.1016/j.psyneuen.2012.02.006
   Becker KJ, 2011, STROKE, V42, P2763, DOI 10.1161/STROKEAHA.111.619593
   Bictash M, 2010, J CLIN EPIDEMIOL, V63, P970, DOI 10.1016/j.jclinepi.2009.10.001
   Bilbo SD, 2009, FRONT BEHAV NEUROSCI, V3, DOI 10.3389/neuro.08.014.2009
   BONITA R, 1988, STROKE, V19, P1497, DOI 10.1161/01.STR.19.12.1497
   Bremmer MA, 2008, J AFFECT DISORDERS, V106, P249, DOI 10.1016/j.jad.2007.07.002
   Bruunsgaard H, 2001, CURR OPIN HEMATOL, V8, P131, DOI 10.1097/00062752-200105000-00001
   Buchhold B, 2007, RESTOR NEUROL NEUROS, V25, P467
   Buga AM, 2013, BIOGERONTOLOGY, V14, P651, DOI 10.1007/s10522-013-9465-0
   Burke DT, 2014, ARCH PHYS MED REHAB, V95, P1055, DOI 10.1016/j.apmr.2014.01.019
   BURN J, 1994, STROKE, V25, P333, DOI 10.1161/01.STR.25.2.333
   Byers AL, 2011, NAT REV NEUROL, V7, P323, DOI 10.1038/nrneurol.2011.60
   Cancello R, 2005, DIABETES, V54, P2277, DOI 10.2337/diabetes.54.8.2277
   Capuron L, 2011, PSYCHOL MED, V41, P1517, DOI 10.1017/S0033291710001984
   Capuron L, 2008, BIOL PSYCHIAT, V64, P896, DOI 10.1016/j.biopsych.2008.05.019
   Capuron L, 2011, PHARMACOL THERAPEUT, V130, P226, DOI 10.1016/j.pharmthera.2011.01.014
   Caraci F, 2010, EUR J PHARMACOL, V626, P64, DOI 10.1016/j.ejphar.2009.10.022
   Cornelis MC, 2012, ANNU REV NUTR, V32, P245, DOI 10.1146/annurev-nutr-071811-150648
   Cubala WJ, 2014, J AFFECT DISORDERS, V152, P534, DOI 10.1016/j.jad.2013.10.004
   Cunningham C, 2005, J NEUROSCI, V25, P9275, DOI 10.1523/JNEUROSCI.2614-05.2005
   Dahl J, 2014, PSYCHONEUROENDOCRINO, V45, P77, DOI 10.1016/j.psyneuen.2014.03.019
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   de Leeuw FE, 2002, BRAIN, V125, P765, DOI 10.1093/brain/awf077
   De Ryck A, 2014, J NEUROL SCI, V347, P159, DOI 10.1016/j.jns.2014.09.038
   Di Napoli M, 2014, STROKE, V45, P59, DOI 10.1161/STROKEAHA.113.001721
   Di Napoli M, 2012, NEUROLOGY, V79, P690, DOI 10.1212/WNL.0b013e318264e3be
   Dilger RN, 2008, J LEUKOCYTE BIOL, V84, P932, DOI 10.1189/jlb.0208108
   Downes CE, 2010, BRIT J PHARMACOL, V160, P1872, DOI 10.1111/j.1476-5381.2010.00864.x
   Elahy M, 2015, IMMUN AGEING, V12, DOI 10.1186/s12979-015-0029-9
   Esposito E, 2013, EXP NEUROL, V249, P33, DOI 10.1016/j.expneurol.2013.08.005
   Evans DL, 2005, BIOL PSYCHIAT, V58, P175, DOI 10.1016/j.biopsych.2005.05.001
   Everson-Rose SA, 2014, STROKE, V45, P2318, DOI 10.1161/STROKEAHA.114.004815
   FAGIOLO U, 1992, ANN NY ACAD SCI, V663, P490, DOI 10.1111/j.1749-6632.1992.tb38712.x
   FAGIOLO U, 1993, EUR J IMMUNOL, V23, P2375, DOI 10.1002/eji.1830230950
   Fenn AM, 2014, BIOL PSYCHIAT, V76, P575, DOI 10.1016/j.biopsych.2013.10.014
   Fisher M, 2009, STROKE, V40, P2244, DOI 10.1161/STROKEAHA.108.541128
   Ferreira EDF, 2011, EUR J NEUROSCI, V34, P1131, DOI 10.1111/j.1460-9568.2011.07824.x
   Freret T, 2015, J NEURAL TRANSM, V122, P55, DOI 10.1007/s00702-013-1154-2
   Furuhashi M, 2014, CLIN MED INSIGHTS-CA, V8, P23, DOI 10.4137/CMC.S17067
   Gencer B, 2016, ATHEROSCLEROSIS, V245, P181, DOI 10.1016/j.atherosclerosis.2015.12.004
   Ghiadoni L, 2000, HYPERTENSION, V35, P501, DOI 10.1161/01.HYP.35.1.501
   Gildengers AG, 2008, AM J GERIAT PSYCHIAT, V16, P194, DOI 10.1097/JGP.0b013e318157c5b1
   Godbout JP, 2006, NEUROL CLIN, V24, P521, DOI 10.1016/j.ncl.2006.03.010
   Goossens GH, 2008, PHYSIOL BEHAV, V94, P206, DOI 10.1016/j.physbeh.2007.10.010
   Goossens GH, 2011, CIRCULATION, V124, P67, DOI 10.1161/CIRCULATIONAHA.111.027813
   Hackett ML, 2005, STROKE, V36, P2296, DOI 10.1161/01.STR.0000183622.75135.a4
   Hanisch UK, 2007, NAT NEUROSCI, V10, P1387, DOI 10.1038/nn1997
   Hellwig K, 2015, ALZHEIMERS RES THER, V7, DOI 10.1186/s13195-015-0161-y
   Henry CJ, 2009, BRAIN BEHAV IMMUN, V23, P309, DOI 10.1016/j.bbi.2008.09.002
   Hinman JD, 2015, BRAIN, V138, P736, DOI 10.1093/brain/awu398
   Howcroft TK, 2013, AGING-US, V5, P84, DOI 10.18632/aging.100531
   Illig T, 2010, NAT GENET, V42, P137, DOI 10.1038/ng.507
   Jeste DV, 2013, BRIT J PSYCHIAT, V202, P81, DOI 10.1192/bjp.bp.112.110643
   Jyothi HJ, 2015, NEUROBIOL AGING, V36, P3321, DOI 10.1016/j.neurobiolaging.2015.08.024
   Kabon B, 2004, ANESTHESIOLOGY, V100, P274, DOI 10.1097/00000542-200402000-00015
   Kekow J, 2010, ANN RHEUM DIS, V69, P222, DOI 10.1136/ard.2008.102509
   Kessler RC, 2005, ARCH GEN PSYCHIAT, V62, P593, DOI 10.1001/archpsyc.62.6.593
   Kettunen J, 2012, NAT GENET, V44, P269, DOI 10.1038/ng.1073
   Kinross J, 2014, CURR OPIN GASTROEN, V30, P196, DOI 10.1097/MOG.0000000000000036
   Knol MJ, 2006, DIABETOLOGIA, V49, P837, DOI 10.1007/s00125-006-0159-x
   Krishnadas R, 2012, J NEUROL NEUROSUR PS, V83, P495, DOI 10.1136/jnnp-2011-301779
   Lanquillon S, 2000, NEUROPSYCHOPHARMACOL, V22, P370, DOI 10.1016/S0893-133X(99)00134-7
   Leonard BE, 2007, NEUROCHEM RES, V32, P1749, DOI 10.1007/s11064-007-9385-y
   Lindner MD, 2003, J NEUROSCI, V23, P10913
   Liu QY, 2013, PROCEEDINGS OF THE 2013 INTERNATIONAL CONFERENCE ON ENERGY, P8
   Locke AE, 2015, NATURE, V518, P197, DOI 10.1038/nature14177
   Loeb DF, 2012, GEN HOSP PSYCHIAT, V34, P588, DOI 10.1016/j.genhosppsych.2012.07.004
   Löppönen P, 2014, J NEUROSURG, V121, P1374, DOI 10.3171/2014.7.JNS132678
   Maes M, 2011, PROG NEURO-PSYCHOPH, V35, P664, DOI 10.1016/j.pnpbp.2010.06.014
   Maes M, 2009, METAB BRAIN DIS, V24, P27, DOI 10.1007/s11011-008-9118-1
   Manwani B, 2013, EXP NEUROL, V249, P120, DOI 10.1016/j.expneurol.2013.08.011
   Manwani B, 2011, BRAIN BEHAV IMMUN, V25, P1689, DOI 10.1016/j.bbi.2011.06.015
   Marazziti D, 2014, CNS SPECTRUMS, V19, P293, DOI 10.1017/S1092852913000667
   Martinac M, 2014, ACTA CLIN CROAT, V53, P55
   Maysami S, 2015, J NEUROINFLAMM, V12, DOI 10.1186/s12974-015-0359-8
   McIntyre Roger S, 2007, Ann Clin Psychiatry, V19, P257, DOI 10.1080/10401230701653377
   Mehta D, 2013, BRAIN BEHAV IMMUN, V31, P205, DOI 10.1016/j.bbi.2013.04.004
   Milaneschi Y, 2009, BIOL PSYCHIAT, V65, P973, DOI 10.1016/j.biopsych.2008.11.011
   Miller AH, 2009, BIOL PSYCHIAT, V65, P732, DOI 10.1016/j.biopsych.2008.11.029
   Molino-Lova R, 2011, NUTR METAB CARDIOVAS, V21, P776, DOI 10.1016/j.numecd.2010.02.003
   Murray C, 2012, NEUROBIOL AGING, V33, P603, DOI 10.1016/j.neurobiolaging.2010.04.002
   Murray KN, 2013, MOL CELL NEUROSCI, V53, P14, DOI 10.1016/j.mcn.2012.09.004
   Nagata R, 2010, J STROKE CEREBROVASC, V19, P236, DOI 10.1016/j.jstrokecerebrovasdis.2009.08.004
   Najjar S, 2013, J NEUROINFLAMM, V10, DOI 10.1186/1742-2094-10-142
   Nemeroff Charles B, 2003, Psychopharmacol Bull, V37, P133
   Nimmerjahn A, 2005, SCIENCE, V308, P1314, DOI 10.1126/science.1110647
   O'Collins VE, 2006, ANN NEUROL, V59, P467, DOI 10.1002/ana.20741
   Okamoto Y, 2012, ACTA NEUROPATHOL, V123, P381, DOI 10.1007/s00401-011-0925-9
   Olefsky JM, 2010, ANNU REV PHYSIOL, V72, P219, DOI 10.1146/annurev-physiol-021909-135846
   Olsen TS, 2008, NEUROEPIDEMIOLOGY, V30, P93, DOI 10.1159/000118945
   Ovbiagele B, 2011, STROKE, V42, P3397, DOI 10.1161/STROKEAHA.111.624957
   Palin K, 2008, NEUROBIOL DIS, V30, P19, DOI 10.1016/j.nbd.2007.11.012
   Papakostas GI, 2013, MOL PSYCHIATR, V18, P332, DOI 10.1038/mp.2011.166
   Pasarica M, 2009, DIABETES, V58, P718, DOI 10.2337/db08-1098
   Penninx BWJH, 2003, BIOL PSYCHIAT, V54, P566, DOI 10.1016/S0006-3223(02)01811-5
   Petcu EB, 2010, VASC CELL, V2, DOI 10.1186/2040-2384-2-26
   Peters SAE, 2014, LANCET, V383, P1973, DOI 10.1016/S0140-6736(14)60040-4
   Phillips CM, 2015, PSYCHONEUROENDOCRINO, V62, P47, DOI 10.1016/j.psyneuen.2015.07.168
   Popa-Wagner A, 2014, BIOGERONTOLOGY, V15, P439, DOI 10.1007/s10522-014-9516-1
   Popa-Wagner A, 2011, AGEING RES REV, V10, P71, DOI 10.1016/j.arr.2009.10.008
   Popa-Wagner A, 2010, CURR NEUROVASC RES, V7, P251, DOI 10.2174/156720210792231813
   Poulsen P, 1999, DIABETOLOGIA, V42, P139, DOI 10.1007/s001250051131
   Raffler J, 2015, PLOS GENET, V11, DOI 10.1371/journal.pgen.1005487
   Raison CL, 2013, JAMA PSYCHIAT, V70, P31, DOI 10.1001/2013.jamapsychiatry.4
   Rajan KB, 2014, STROKE, V45, P2563, DOI 10.1161/STROKEAHA.114.005143
   Ransohoff RM, 2010, NATURE, V468, P253, DOI 10.1038/nature09615
   Rausch ME, 2008, INT J OBESITY, V32, P451, DOI 10.1038/sj.ijo.0803744
   Reimer MM, 2011, J NEUROSCI, V31, P18185, DOI 10.1523/JNEUROSCI.4936-11.2011
   Ritzel RM, 2015, J NEUROINFLAMM, V12, DOI 10.1186/s12974-015-0329-1
   Rizzo M, 2009, INTERN MED J, V39, P539, DOI 10.1111/j.1445-5994.2009.01955.x
   Rizzo M, 2009, CORONARY ARTERY DIS, V20, P15, DOI 10.1097/MCA.0b013e3283109065
   Roger VL, 2012, CIRCULATION, V125, P188, DOI 10.1161/CIR.0b013e3182456d46
   Roman TS, 2015, AM J HUM GENET, V97, P801, DOI 10.1016/j.ajhg.2015.10.016
   Rush AJ, 2006, AM J PSYCHIAT, V163, P1905, DOI 10.1176/appi.ajp.163.11.1905
   Ryu WS, 2011, CEREBROVASC DIS, V32, P170, DOI 10.1159/000328250
   Sandu RE, 2015, NEURAL REGEN RES, V10, P1349, DOI 10.4103/1673-5374.165208
   Schiffrin EL, 2014, J HYPERTENS, V32, P228, DOI 10.1097/HJH.0000000000000042
   Schmidt FM, 2014, PSYCHIAT DANUB, V26, P288
   Shimizu M, 2011, ATHEROSCLEROSIS, V219, P316, DOI 10.1016/j.atherosclerosis.2011.06.030
   Shin JA, 2015, BRAIN BEHAV IMMUN, V50, P221, DOI 10.1016/j.bbi.2015.07.008
   Shungin D, 2015, NATURE, V518, P187, DOI 10.1038/nature14132
   Sluzewska A, 1997, NEUROPSYCHOBIOLOGY, V35, P123, DOI 10.1159/000119332
   Stancel N, 2016, CLIN CHEM, V62, P320, DOI 10.1373/clinchem.2015.243923
   Suhre K, 2011, NATURE, V477, P54, DOI 10.1038/nature10354
   Surtees PG, 2008, PSYCHOSOM MED, V70, P850, DOI 10.1097/PSY.0b013e318183acd5
   Swardfager W, 2010, BIOL PSYCHIAT, V68, P930, DOI 10.1016/j.biopsych.2010.06.012
   Taylor WD, 2013, MOL PSYCHIATR, V18, P963, DOI 10.1038/mp.2013.20
   Teslovich TM, 2010, NATURE, V466, P707, DOI 10.1038/nature09270
   Tiemeier H, 2003, J AM GERIATR SOC, V51, P1105, DOI 10.1046/j.1532-5415.2003.51359.x
   Tousoulis D, 2011, CURR PHARM DESIGN, V17, P4089, DOI 10.2174/138161211798764843
   Towfighi A, 2009, STROKE, V40, P2704, DOI 10.1161/STROKEAHA.109.550228
   Townsend BE, 2016, EXP GERONTOL, V73, P42, DOI 10.1016/j.exger.2015.11.004
   Tyring S, 2006, LANCET, V367, P29, DOI 10.1016/S0140-6736(05)67763-X
   van den Biggelaar AHJ, 2007, EXP GERONTOL, V42, P693, DOI 10.1016/j.exger.2007.01.011
   Vemmos K, 2011, STROKE, V42, P30, DOI 10.1161/STROKEAHA.110.593434
   Wakselman S, 2008, J NEUROSCI, V28, P8138, DOI 10.1523/JNEUROSCI.1006-08.2008
   Walker AK, 2014, PHARMACOL REV, V66, P80, DOI 10.1124/pr.113.008144
   Willey JZ, 2012, STROKE, V43, P2369, DOI 10.1161/STROKEAHA.112.660993
   Wolkowitz OM, 2010, DEPRESS ANXIETY, V27, P327, DOI 10.1002/da.20686
   Ye SM, 1999, J NEUROIMMUNOL, V93, P139, DOI 10.1016/S0165-5728(98)00217-3
   Yu TS, 2016, NEUROSCIENTIST, V22, P61, DOI 10.1177/1073858414563616
   Zhao L, 2014, J STROKE CEREBROVASC, V23, pE201, DOI 10.1016/j.jstrokecerebrovasdis.2013.10.002
   Zuliani G, 2007, INT J GERIATR PSYCH, V22, P305, DOI 10.1002/gps.1674
   Zunszain Patricia A, 2013, Curr Top Behav Neurosci, V14, P135, DOI 10.1007/7854_2012_211
NR 157
TC 4
Z9 4
U1 0
U2 14
PU EDITURA ACAD ROMANE
PI BUCURESTI
PA CALEA 13 SEPTEMBRIE NR 13, SECTOR 5, BUCURESTI 050711, ROMANIA
SN 1220-0522
EI 2066-8279
J9 ROM J MORPHOL EMBRYO
JI Rom. J. Morphol. Embryol.
PY 2016
VL 57
IS 1
BP 33
EP 43
PG 11
WC Developmental Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology
GA DM0PR
UT WOS:000376048800003
PM 27151686
DA 2025-06-11
ER

PT J
AU Aouira, N
   Khan, S
   McDermott, B
   Heussler, H
   Haywood, A
   Karaksha, A
   Bor, W
AF Aouira, Nisreen
   Khan, Sohil
   McDermott, Brett
   Heussler, Helen
   Haywood, Alison
   Karaksha, Abdullah
   Bor, William
TI Paper based vs. electronic records for clinical audit: Evidence of
   documentation of medication safety monitoring in youth prescribed
   antipsychotics
SO CHILDREN AND YOUTH SERVICES REVIEW
LA English
DT Article
ID METABOLIC SYNDROME; CHILDREN; COMPUTER; ADOLESCENTS; DRUGS; RISK
AB Background: Since the development of digital records, claims have been made that they improve audits. Clinical audits play important role in evaluation of evidence-practice gaps. Antipsychotic medications are one of the commonly prescribed group of drugs in severe adverse mental conditions. Youth and young people are highly prone to develop drug induced metabolic syndrome. Present study evaluated the extent of data documentation on evidence for metabolic monitoring of anti-psychotics and compared paper based to electronic records with good documentation standards.
   Methods: First phase of this study involved a retrospective clinical audit of paper-based documentation on the extent of documentation of weight (primary outcome); lipid and blood glucose (secondary outcomes) of youth prescribed atypical antipsychotics. This was undertaken in three public mental health clinics and a public/private developmental service in Australia based on paper-based documentation. The second phase included auditing electronic data capture from one community clinic. Evidence of documentation was compared with practice standards and published clinical audits (adherence rate benchmark: 40-60%).
   Results: A total of 310 cases were assessed of which 51 and 37 cases met the eligibility criteria for paper-based and electronic based audit respectively as a component of clinical audit. Evidence of paper documentation of weight was 43% among participants and was comparable with other published clinical audits (p = 0.07) with poor monitoring rates for other blood tests. Findings revealed poor rate of documentation at 35.1% (13 cases), 5.4% (2 cases) and 8.1% (3 cases) for weight, lipid assessments and glucose monitoring, respectively based on electronic records.
   Conclusion: Present study demonstrate lack of good documentation practices on metabolic monitoring of youth prescribed antipsychotics. It appears transitioning from paper to electronic records did not impact the rate of increase in documentation of metabolic monitoring. This study recommends inclusion of e-monitoring icon with built in metabolic monitoring chart as a component of youth prescribed antipsychotic case records. Good documentation practice is a first step in determination of causality of antipsychotics induced metabolic syndrome. Appropriate strategies to a user-friendly electronic reminder system will be crucial to address on the mechanistic of documentation.
C1 [Aouira, Nisreen; Khan, Sohil; Haywood, Alison; Karaksha, Abdullah] Griffith Univ, Sch Pharm & Pharmacol, Menzies Hlth Inst, Gold Coast, Australia.
   [Khan, Sohil; Heussler, Helen; Haywood, Alison; Bor, William] Univ Queensland, Mater Res Inst, South Brisbane, Australia.
   [Khan, Sohil] Manipal Acad Higher Educ, Prasanna Inst Publ Hlth, Manipal, India.
   [Khan, Sohil] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Manipal, India.
   [McDermott, Brett] James Cook Univ, Townsville Clin Sch, Townsville, Australia.
   [Heussler, Helen; Bor, William] Childrens Hlth Queensland Hosp & Hlth Serv, South Brisbane, Australia.
C3 Menzies Health Institute Queensland; Griffith University; Griffith
   University - Gold Coast Campus; Mater Research; University of
   Queensland; Manipal Academy of Higher Education (MAHE); Manipal Academy
   of Higher Education (MAHE); James Cook University; Childrens Health
   Queensland Hospital & Health Service
RP Khan, S (corresponding author), Griffith Univ, Sch Pharm & Pharmacol, Menzies Hlth Inst, Gold Coast, Australia.; Khan, S (corresponding author), Univ Queensland, Mater Res Inst, South Brisbane, Australia.; Khan, S (corresponding author), Manipal Acad Higher Educ, Prasanna Inst Publ Hlth, Manipal, India.; Khan, S (corresponding author), Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Manipal, India.
EM s.khan@griffith.edu.au
RI Bor, William/J-2215-2015
OI McDermott, Brett/0000-0002-6639-1767; Haywood,
   Alison/0000-0002-5354-8868; Aouira, Nisreen/0000-0001-9297-6737
FU Institutional Funding (Griffith University, Australia)
FX Institutional Funding (Griffith University, Australia).
CR Adane K, 2013, ARCH PUBLIC HEALTH, V71, DOI 10.1186/0778-7367-71-27
   [Anonymous], 2011, NEW HOR HLTH MOB TEC
   [Anonymous], NATURE REV GENETICS
   Australian Commission on Safety and Quality in Health Care, 2014, SUPP QUAL PRACT
   Barnes TRE, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2015-007633
   Bomboy K T., 2018, Does Improved Access to Metabolic Monitoring Forms Increase Provider Adherence to APA Guidelines on Antipsychotic Medication Management?
   BURNUM JF, 1989, ANN INTERN MED, V110, P482, DOI 10.7326/0003-4819-110-6-482
   Carney R, 2018, EARLY INTERV PSYCHIA, V12, P153, DOI 10.1111/eip.12288
   Cole T J, 2004, BMC Pediatr, V4, P6
   Correll CU, 2009, JAMA-J AM MED ASSOC, V302, P1765, DOI 10.1001/jama.2009.1549
   Coughlin M, 2018, CAN J PSYCHIAT, V63, P240, DOI 10.1177/0706743717751693
   Curtis J, 2012, EARLY INTERV PSYCHIA, V6, P347, DOI 10.1111/j.1751-7893.2011.00315.x
   Delate T, 2014, JAMA PEDIATR, V168, P679, DOI 10.1001/jamapediatrics.2014.224
   DelMonte MT, 2012, J CLIN PHARM THER, V37, P668, DOI 10.1111/j.1365-2710.2012.01369.x
   Eapen V, 2013, AUST NZ J PSYCHIAT, V47, P435, DOI 10.1177/0004867412463169
   Ellis D., 2016, WOMENS CHILDRENS HOS
   Foley DL, 2011, ARCH GEN PSYCHIAT, V68, P609, DOI 10.1001/archgenpsychiatry.2011.2
   Harrison JN, 2012, J PEDIATR HEALTH CAR, V26, P139, DOI 10.1016/j.pedhc.2011.10.009
   Jeffrey J., 2015, BMJ QUALITY IMPROVEM, V4
   Jha Raghbendra., 2003, Macroeconomics for developing countries
   Kahn RS, 2008, LANCET, V371, P1085, DOI 10.1016/S0140-6736(08)60486-9
   Koyama S., 2013, PEDIAT PEDS
   Laugharne J, 2016, AUSTRALAS PSYCHIATRY, V24, P62, DOI 10.1177/1039856215618521
   Mitchell AJ, 2012, PSYCHOL MED, V42, P125, DOI 10.1017/S003329171100105X
   Morrato EH, 2009, DIABETES CARE, V32, P1037, DOI 10.2337/dc08-1720
   Nash K., 2016, Clinical Schizophrenia Related Psychoses, V10, P145, DOI [10.3371/19351232.10.3, DOI 10.3371/19351232.10.3]
   Nasrallah H. A., 2011, CURR PSYCHIAT, V10, P12
   National Centre for Classification in Health, 2003, GOOD CLIN DOC GUID E
   Newcomer John W, 2004, J Clin Psychopharmacol, V24, pS1, DOI 10.1097/01.jcp.0000142281.85207.d5
   NPS, 2014, HLTH NEWS EVIDENCE
   Olsson S, 1998, DRUG SAFETY, V19, P1, DOI 10.2165/00002018-199819010-00001
   Pringsheim T, 2012, PAED CHILD HEALT-CAN, V17, p22B, DOI 10.1093/pch/17.suppl_b.22B
   Pringsheim T, 2011, PAED CHILD HEALT-CAN, V16, P581, DOI 10.1093/pch/16.9.581
   Rogol AD, 2000, AM J CLIN NUTR, V72, p521S, DOI 10.1093/ajcn/72.2.521S
   Ross E, 2018, J CLIN PSYCHOPHARM, V38, P447, DOI 10.1097/JCP.0000000000000931
   Roukema J, 2006, PEDIATRICS, V117, P15, DOI 10.1542/peds.2004-2741
   Safer DJ, 2004, J CLIN PSYCHOPHARM, V24, P429, DOI 10.1097/01.jcp.0000130558.86125.5b
   Scott P., 2009, J MANAGEMENT MARKETI, V2, P151
   Scott PJ, 2016, BMC MED INFORM DECIS, V16, DOI 10.1186/s12911-016-0380-6
   Smyth RMD, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0024061
   Stausberg J, 2003, J AM MED INFORM ASSN, V10, P470, DOI 10.1197/jamia.M1290
   VANDERLEI J, 1991, METHOD INFORM MED, V30, P79
   Weiskopf NG, 2013, J AM MED INFORM ASSN, V20, P144, DOI 10.1136/amiajnl-2011-000681
   World Health Organization, GUID MED REC CLIN DO
NR 44
TC 1
Z9 1
U1 0
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0190-7409
EI 1873-7765
J9 CHILD YOUTH SERV REV
JI Child. Youth Serv. Rev.
PD FEB
PY 2020
VL 109
AR 104666
DI 10.1016/j.childyouth.2019.104666
PG 6
WC Family Studies; Social Work
WE Social Science Citation Index (SSCI)
SC Family Studies; Social Work
GA KM6MZ
UT WOS:000514253500008
DA 2025-06-11
ER

PT J
AU Jakubowska-Kowal, K
   Skrzynska, K
   Gawlik-Starzyk, A
AF Jakubowska-Kowal, Karolina
   Skrzynska, Karolina
   Gawlik-Starzyk, Aneta
TI Treatment and complications of PCOS in adolescents - what's new in 2023?
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE polycystic ovary syndrome; adolescent; oligomenorrhea; hirsutism;
   hyperandrogenism
ID POLYCYSTIC-OVARY-SYNDROME; PREVALENCE; CONSENSUS; OBESITY
AB Polycystic ovary syndrome (PCOS) is a disease affecting as many as about 10% of women of reproductive age, also 3-11% of teenage patients, and can lead to numerous complications and coexists with many diseases. Research is ongoing to establish an appropriate diagnostic and therapeutic path for adolescent girls with PCOS. It is also important to implement appropriate check-ups among teenagers with PCOS in order to prevent PCOS complications and initiate appropriate treatment as soon as possible and prevent the long-term consequences of these complications. The relationship between the co-occurrence of PCOS and diseases such as metabolic syndrome, hypertension, obesity, insulin resistance, type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) is increasingly being investigated. A great attention is also being paid to the problem of mental health in this group of patients. In our study, we will review the latest reports on the treatment of PCOS and look at the complications that this syndrome can cause.
C1 [Jakubowska-Kowal, Karolina; Skrzynska, Karolina; Gawlik-Starzyk, Aneta] Med Univ Silesia, Dept Pediat & Pediat Endocrinol, Katowice, Poland.
C3 Medical University of Silesia
RP Jakubowska-Kowal, K (corresponding author), Med Univ Silesia, Dept Pediat & Pediat Endocrinol, Katowice, Poland.
EM kjakubowskakowal@gmail.com
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. The publication fee was
   covered by the Medical University of Silesia in Katowice
CR Alkan I, 2023, HISTOCHEM CELL BIOL, V160, P27, DOI 10.1007/s00418-023-02188-3
   Bassols J, 2023, TRIALS, V24, DOI 10.1186/s13063-022-07050-w
   Benson J, 2020, CAN J DIABETES, V44, P507, DOI 10.1016/j.jcjd.2020.05.015
   Bhardwaj P, 2022, J FAM MED PRIM CARE, V11, P7769, DOI 10.4103/jfmpc.jfmpc_1201_22
   Bialka-Kosiec A, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.1000261
   Bonab SB, 2023, SCI SPORT, V38, P565, DOI 10.1016/j.scispo.2022.11.001
   Bozdag G, 2016, HUM REPROD, V31, P2841, DOI 10.1093/humrep/dew218
   Cooney LG, 2017, HUM REPROD, V32, P1075, DOI 10.1093/humrep/dex044
   Díaz M, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1125569
   Ding R, 2022, FRONT PSYCHIATRY, V13, DOI 10.3389/fpsyt.2022.984653
   Fauser BCJM, 2012, FERTIL STERIL, V97, P28, DOI 10.1016/j.fertnstert.2011.09.024
   Fauser BCJM, 2004, HUM REPROD, V19, P41, DOI 10.1093/humrep/deh098
   Fazleen NE, 2018, DIAB MET SYND CLIN R, V12, P1083, DOI 10.1016/j.dsx.2018.03.014
   Fu LY, 2023, REPROD SCI, V30, P28, DOI 10.1007/s43032-022-00864-8
   Garcia-Beltran C, 2023, HORM RES PAEDIAT, V96, P458, DOI 10.1159/000529183
   Giannouli A, 2023, J CLIN MED, V12, DOI 10.3390/jcm12020557
   Gupta J, 2022, BMC ENDOCR DISORD, V22, DOI 10.1186/s12902-022-01098-0
   Hajivandi L, 2022, BMC HEALTH SERV RES, V22, DOI 10.1186/s12913-022-08334-2
   Ibáñez L, 2023, TRENDS MOL MED, V29, P354, DOI 10.1016/j.molmed.2023.02.006
   Ibáñez L, 2017, HORM RES PAEDIAT, V88, P371, DOI 10.1159/000479371
   Kara O, 2023, CLIN EXP PEDIATR, V66, P395, DOI 10.3345/cep.2023.00353
   Kara O, 2022, ARCH WOMEN MENT HLTH, V25, P911, DOI 10.1007/s00737-022-01264-2
   Long CY, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.980405
   Manzano-Nunez R, 2023, J CLIN MED, V12, DOI 10.3390/jcm12030856
   Nasiri-Amiri Fatemeh, 2023, Int J Adolesc Med Health, V35, P233, DOI 10.1515/ijamh-2022-0065
   Naz MSG, 2023, J PEDIATR NURS, V72, pE1, DOI 10.1016/j.pedn.2023.05.009
   Naz MSG, 2023, EUR J PEDIATR, V182, P2393, DOI 10.1007/s00431-023-04875-8
   Naz MSG, 2019, INT J REPROD BIOMED, V17, P533, DOI 10.18502/ijrm.v17i8.4818
   Patel-Sanchez N, 2023, J PEDIATR ENDOCR MET, V36, P441, DOI 10.1515/jpem-2022-0527
   Raeisi T, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0246200
   Ruan XY, 2023, GYNECOL ENDOCRINOL, V39, DOI 10.1080/09513590.2023.2216807
   Scarinci E, 2023, MINERVA OBSTET GYNEC, V75, P165, DOI 10.23736/S2724-606X.21.04983-6
   Tan HW, 2022, FRONT PSYCHIATRY, V13, DOI 10.3389/fpsyt.2022.937280
   Taylor AE, 2022, J ENDOCR SOC, V6, DOI 10.1210/jendso/bvac037
   Tsiroukidou K, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24044205
   Unlu C, 2023, J PEDIATR ENDOCR MET, V36, P283, DOI 10.1515/jpem-2022-0455
   Urbano F, 2022, CHILDREN-BASEL, V9, DOI 10.3390/children9111748
   Wekker V, 2020, HUM REPROD UPDATE, V26, P942, DOI 10.1093/humupd/dmaa029
NR 38
TC 0
Z9 0
U1 5
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD OCT 2
PY 2024
VL 15
AR 1436952
DI 10.3389/fendo.2024.1436952
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA I8Z0L
UT WOS:001333069400001
PM 39415788
OA gold
DA 2025-06-11
ER

PT J
AU Numakawa, T
   Richards, M
   Nakajima, S
   Adachi, N
   Furuta, M
   Odaka, H
   Kunugi, H
AF Numakawa, Tadahiro
   Richards, Misty
   Nakajima, Shingo
   Adachi, Naoki
   Furuta, Miyako
   Odaka, Haruki
   Kunugi, Hiroshi
TI The role of brain-derived neurotrophic factor in comorbid depression:
   possible linkage with steroid hormones, cytokines, and nutrition
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE depression; BDNF; glucocorticoid; estrogen; cytokines; obesity;
   flavonoids
ID PITUITARY-ADRENAL AXIS; ESTROGEN-RECEPTOR-BETA; NECROSIS-FACTOR-ALPHA;
   HIGH-FAT; SYNAPTIC PLASTICITY; VAL66MET POLYMORPHISM; HIPPOCAMPAL
   PLASTICITY; METABOLIC SYNDROME; BDNF; ZINC
AB Increasing evidence demonstrates a connection between growth factor function (including brain-derived neurotrophic factor, BDNF), glucocorticoid levels (one of the steroid hormones), and the pathophysiology of depressive disorders. Because both BDNF and glucocorticoids regulate synaptic function in the central nervous system, their functional interaction is of major concern. Interestingly, alterations in levels of estrogen, another steroid hormone, may play a role in depressive-like behavior in postpartum females with fluctuations of BDNF-related molecules in the brain. BDNF and cytokines, which are protein regulators of inflammation, stimulate multiple intracellular signaling cascades involved in neuropsychiatric illness. Pro-inflammatory cytokines may increase vulnerability to depressive symptoms, such as the increased risk observed in patients with cancer and/or autoimmune diseases. In this review, we discuss the possible relationship between inflammation and depression, in addition to the cross-talk among cytokines, BDNF, and steroids. Further, since nutritional status has been shown to affect critical pathways involved in depression through both BDNF function and the monoamine system, we also review current evidence surrounding diet and supplementation (e.g., flavonoids) on BDNF-mediated brain functions.
C1 [Numakawa, Tadahiro; Nakajima, Shingo; Adachi, Naoki; Odaka, Haruki; Kunugi, Hiroshi] Natl Inst Neurosci, Natl Ctr Neurol & Psychiat, Dept Mental Disorder Res, 4-1-1 Ogawa Higashi, Kodaira, Tokyo, Japan.
   [Richards, Misty] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Los Angeles, CA USA.
   [Furuta, Miyako] St Marianna Univ, Sch Med, Dept Physiol, Kawasaki, Kanagawa, Japan.
C3 National Center for Neurology & Psychiatry - Japan; University of
   California System; University of California Los Angeles; Saint Marianna
   University
RP Numakawa, T (corresponding author), Natl Inst Neurosci, Natl Ctr Neurol & Psychiat, Dept Mental Disorder Res, 4-1-1 Ogawa Higashi, Kodaira, Tokyo, Japan.
EM numakawa@ncnp.go.jp
RI Odaka, Haruki/AAQ-4448-2020; Kunugi, Hiroshi/ABC-5260-2021; Richards,
   Misty/JVN-6897-2024
OI Adachi, Naoki/0000-0002-4850-1467; Kunugi, Hiroshi/0000-0002-7209-3790;
   Odaka, Haruki/0000-0001-5632-2680
FU Health and Labor Sciences Research Grants (Comprehensive Research on
   Disability, Health, and Welfare) [H21-kokoro-002]; Intramural Research
   Grant for Neurological and Psychiatric Disorders of NCNP [24-11]; Takeda
   Science Foundation; JSPS KAKENHI from the Ministry of Education,
   Culture, Sports, Science, and Technology of Japan [24300139, 25640019]
FX This study was supported by the Health and Labor Sciences Research
   Grants (Comprehensive Research on Disability, Health, and Welfare
   H21-kokoro-002) (Hiroshi Kunugi), Intramural Research Grant (No. 24-11)
   for Neurological and Psychiatric Disorders of NCNP (Hiroshi Kunugi), and
   Takeda Science Foundation (Tadahiro Numakawa). This is also supported by
   a grant from the Grant-in-Aid for Scientific Research (B) (JSPS KAKENHI
   Grant Number 24300139) (Tadahiro Numakawa) and for Challenging
   Exploratory Research (JSPS KAKENHI Grant Number 25640019) (Tadahiro
   Numakawa) from the Ministry of Education, Culture, Sports, Science, and
   Technology of Japan.
CR Anisman H, 2007, J NEUROIMMUNOL, V186, P45, DOI 10.1016/j.jneuroim.2007.02.008
   Babayan AH, 2013, J NEUROENDOCRINOL, V25, P1163, DOI 10.1111/jne.12108
   Barha CK, 2010, NEUROPSYCHOPHARMACOL, V35, P547, DOI 10.1038/npp.2009.161
   Beckley EH, 2011, PSYCHONEUROENDOCRINO, V36, P824, DOI 10.1016/j.psyneuen.2010.11.004
   BERKENBOSCH F, 1987, SCIENCE, V238, P524, DOI 10.1126/science.2443979
   Bhutada P, 2010, PROG NEURO-PSYCHOPH, V34, P955, DOI 10.1016/j.pnpbp.2010.04.025
   Bluthé RM, 2000, EUR J NEUROSCI, V12, P4447, DOI 10.1046/j.1460-9568.2000.01348.x
   Bourke CH, 2013, PSYCHOPHARMACOLOGY, V228, P231, DOI 10.1007/s00213-013-3030-z
   Bredemann TM, 2014, PSYCHONEUROENDOCRINO, V42, P77, DOI 10.1016/j.psyneuen.2014.01.004
   Briones TL, 2013, NEUROSCIENCE, V254, P324, DOI 10.1016/j.neuroscience.2013.09.031
   Brown KW, 2003, PSYCHOSOM MED, V65, P636, DOI 10.1097/01.PSY.0000077503.96903.A6
   Cardoso TD, 2014, NEUROCHEM RES, V39, P1571, DOI 10.1007/s11064-014-1349-4
   Caryalho AF, 2014, CANCER TREAT REV, V40, P349, DOI 10.1016/j.ctrv.2013.09.009
   Chaieb L, 2014, NEUROGENETICS, V15, P1, DOI 10.1007/s10048-014-0393-1
   Chen A, 2013, BIOMED REP, V1, P167, DOI 10.3892/br.2012.48
   Chen J, 2011, NEUROSCI LETT, V499, P181, DOI 10.1016/j.neulet.2011.05.054
   Chen MD, 2000, OBES RES, V8, P525, DOI 10.1038/oby.2000.65
   Chowanadisai W, 2013, P NATL ACAD SCI USA, V110, P9903, DOI 10.1073/pnas.1222142110
   Comasco E, 2011, ARCH WOMEN MENT HLTH, V14, P453, DOI 10.1007/s00737-011-0239-x
   Cordeira JW, 2014, J NEUROSCI, V34, P554, DOI 10.1523/JNEUROSCI.1572-13.2014
   Cucinelli F, 2002, METABOLISM, V51, P137, DOI 10.1053/meta.2002.29971
   Cui J, 2013, TRENDS MOL MED, V19, P197, DOI 10.1016/j.molmed.2012.12.007
   Dahl J, 2014, PSYCHONEUROENDOCRINO, V45, P77, DOI 10.1016/j.psyneuen.2014.03.019
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   De Crescenzo F, 2014, J AFFECT DISORDERS, V152, P39, DOI 10.1016/j.jad.2013.09.019
   Dennis CL, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001690.pub2
   Desmarais JE, 2009, J CLIN PSYCHIAT, V70, P1688, DOI 10.4088/JCP.08r04856blu
   Donner N, 2009, NEUROSCIENCE, V163, P705, DOI 10.1016/j.neuroscience.2009.06.046
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Duthie G, 2012, OXID MED CELL LONGEV, V2012, DOI 10.1155/2012/165127
   Elfving B, 2012, J PSYCHIATR RES, V46, P1118, DOI 10.1016/j.jpsychires.2012.05.003
   ELMALLAKH RS, 1995, BIOL PSYCHIAT, V37, P235, DOI 10.1016/0006-3223(94)00201-D
   English AW, 2013, P NATL ACAD SCI USA, V110, P16217, DOI 10.1073/pnas.1303646110
   Fargali S, 2012, J MOL NEUROSCI, V48, P654, DOI 10.1007/s12031-012-9790-9
   Fineberg AM, 2013, BIOL PSYCHIAT, V73, P951, DOI 10.1016/j.biopsych.2013.01.001
   Francis HM, 2013, PROTEOMICS, V13, P3076, DOI 10.1002/pmic.201300124
   Freeman EW, 2004, ARCH GEN PSYCHIAT, V61, P62, DOI 10.1001/archpsyc.61.1.62
   Furuta M, 2013, ENDOCRINOLOGY, V154, P3807, DOI 10.1210/en.2012-2136
   Giles GE, 2013, NUTR REV, V71, P727, DOI 10.1111/nure.12066
   González-Vallinas M, 2013, NUTR REV, V71, P585, DOI 10.1111/nure.12051
   Gronli O, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0082793
   Halaris A, 2013, CURR PSYCHIAT REP, V15, DOI 10.1007/s11920-013-0400-5
   Hantsoo L, 2014, PSYCHOPHARMACOLOGY, V231, P939, DOI 10.1007/s00213-013-3316-1
   Harte-Hargrove LC, 2013, NEUROSCIENCE, V239, P46, DOI 10.1016/j.neuroscience.2012.12.029
   Hayley S, 2013, BRAIN BEHAV IMMUN, V31, P115, DOI 10.1016/j.bbi.2012.07.023
   Herbert J, 2013, PSYCHOL MED, V43, P449, DOI 10.1017/S0033291712000955
   Holsen LM, 2011, J AFFECT DISORDERS, V131, P379, DOI 10.1016/j.jad.2010.11.024
   Hong KW, 2012, OBESITY, V20, P1871, DOI 10.1038/oby.2011.352
   Huang LP, 2013, MOL ASPECTS MED, V34, P548, DOI 10.1016/j.mam.2012.05.008
   Huang YZ, 2008, NEURON, V57, P546, DOI 10.1016/j.neuron.2007.11.026
   Huth L, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0102558
   Ichim G, 2012, EXP CELL RES, V318, P1221, DOI 10.1016/j.yexcr.2012.03.006
   Jalsrai A, 2014, AM J CHINESE MED, V42, P119, DOI 10.1142/S0192415X14500086
   Jang SW, 2010, P NATL ACAD SCI USA, V107, P2687, DOI 10.1073/pnas.0913572107
   Jembrek MJ, 2012, J MOL NEUROSCI, V47, P286, DOI 10.1007/s12031-012-9737-1
   Jeong J, 2013, MOL ASPECTS MED, V34, P612, DOI 10.1016/j.mam.2012.05.011
   Jiang ML, 2013, HUM MOL GENET, V22, P2462, DOI 10.1093/hmg/ddt098
   Kaczmarczyk MM, 2013, PSYCHONEUROENDOCRINO, V38, P1553, DOI 10.1016/j.psyneuen.2013.01.004
   Kaster MP, 2012, NEUROPHARMACOLOGY, V62, P419, DOI 10.1016/j.neuropharm.2011.08.018
   Kawabata K, 2010, J NUTR BIOCHEM, V21, P374, DOI 10.1016/j.jnutbio.2009.01.008
   Kenis G, 2011, INT J NEUROPSYCHOPH, V14, P247, DOI 10.1017/S1461145710000830
   Kim H, 2012, J CLIN INVEST, V122, P2940, DOI 10.1172/JCI61884
   Kim SS, 2012, J NUTR BIOCHEM, V23, P1314, DOI 10.1016/j.jnutbio.2011.07.012
   Kirshenbaum GS, 2014, NEUROSCIENCE, V260, P195, DOI 10.1016/j.neuroscience.2013.12.011
   Kohli MA, 2010, ARCH GEN PSYCHIAT, V67, P348, DOI 10.1001/archgenpsychiatry.2009.201
   Lamkin DM, 2011, BRAIN BEHAV IMMUN, V25, P555, DOI 10.1016/j.bbi.2010.12.010
   Leuner B, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0089912
   Li ZZ, 2013, J PSYCHIATR RES, V47, P8, DOI 10.1016/j.jpsychires.2012.10.003
   Liang J, 2013, ANNU REV PHYSIOL, V75, P225, DOI 10.1146/annurev-physiol-030212-183708
   Lindahl V, 2005, ARCH WOMEN MENT HLTH, V8, P77, DOI 10.1007/s00737-005-0080-1
   Liu Y, 2012, J AFFECT DISORDERS, V139, P230, DOI 10.1016/j.jad.2011.08.003
   Loftis JM, 2004, J AFFECT DISORDERS, V82, P175, DOI 10.1016/j.jad.2004.04.002
   Lopresti AL, 2013, PROG NEURO-PSYCHOPH, V45, P92, DOI 10.1016/j.pnpbp.2013.05.005
   Lu B, 2013, NAT REV NEUROSCI, V14, P401, DOI 10.1038/nrn3505
   Lund TD, 2005, ENDOCRINOLOGY, V146, P797, DOI 10.1210/en.2004-1158
   Lutgendorf SK, 2008, J CLIN ONCOL, V26, P4820, DOI 10.1200/JCO.2007.14.1978
   Maniam J, 2010, BEHAV BRAIN RES, V208, P72, DOI 10.1016/j.bbr.2009.11.005
   Marqués-Iturria I, 2014, AM J MED GENET B, V165, P245, DOI 10.1002/ajmg.b.32229
   Martinac M, 2014, ACTA CLIN CROAT, V53, P55
   Martinez JM, 2012, DEPRESS ANXIETY, V29, P32, DOI 10.1002/da.20876
   Mehta D, 2014, PSYCHOL MED, V44, P2309, DOI 10.1017/S0033291713003231
   Mihara M, 2012, CLIN SCI, V122, P143, DOI 10.1042/CS20110340
   Miller BJ, 2011, BIOL PSYCHIAT, V70, P663, DOI 10.1016/j.biopsych.2011.04.013
   Mlyniec K, 2014, NEUROPHARMACOLOGY, V79, P290, DOI 10.1016/j.neuropharm.2013.12.001
   Mlyniec K, 2013, BEHAV BRAIN RES, V238, P30, DOI 10.1016/j.bbr.2012.10.020
   Murphy ML, 2012, BIOL PSYCHIAT, V72, P663, DOI 10.1016/j.biopsych.2012.04.015
   Myers B, 2014, FRONT NEUROENDOCRIN, V35, P180, DOI 10.1016/j.yfrne.2013.12.003
   Nikseresht S, 2012, ARCH IRAN MED, V15, P306, DOI 012155/AIM.0012
   Noble EE, 2011, AM J PHYSIOL-REG I, V300, pR1053, DOI 10.1152/ajpregu.00776.2010
   Numakawa T, 2013, NEUROSCIENCE, V239, P157, DOI 10.1016/j.neuroscience.2012.09.073
   O'Connor JC, 2009, MOL PSYCHIATR, V14, P511, DOI 10.1038/sj.mp.4002148
   Ohgi Y, 2013, PHARMACOL BIOCHEM BE, V103, P853, DOI 10.1016/j.pbb.2012.12.003
   Pace TWW, 2007, BRAIN BEHAV IMMUN, V21, P9, DOI 10.1016/j.bbi.2006.08.009
   Panchal SK, 2012, J NUTR, V142, P1026, DOI 10.3945/jn.111.157263
   Pariante CM, 1999, ENDOCRINOLOGY, V140, P4359, DOI 10.1210/en.140.9.4359
   Patani N, 2011, CANCER CELL INT, V11, DOI 10.1186/1475-2867-11-23
   Pawlby S, 2009, J AFFECT DISORDERS, V113, P236, DOI 10.1016/j.jad.2008.05.018
   Perez-Rosello T, 2013, J NEUROSCI, V33, P9259, DOI 10.1523/JNEUROSCI.0237-13.2013
   Pinheiro RT, 2012, NEUROCHEM RES, V37, P2229, DOI 10.1007/s11064-012-0851-9
   Pinsonneault JK, 2013, ARCH WOMEN MENT HLTH, V16, P499, DOI 10.1007/s00737-013-0373-8
   Popovics P, 2011, CELL MOL LIFE SCI, V68, P85, DOI 10.1007/s00018-010-0517-1
   Pyter LM, 2009, P NATL ACAD SCI USA, V106, P9069, DOI 10.1073/pnas.0811949106
   Raison CL, 2003, BIOL PSYCHIAT, V54, P283, DOI 10.1016/S0006-3223(03)00413-X
   Rasgon NL, 2007, J PSYCHIATR RES, V41, P338, DOI 10.1016/j.jpsychires.2006.03.009
   Rios M, 2001, MOL ENDOCRINOL, V15, P1748, DOI 10.1210/me.15.10.1748
   Rizzo SJS, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.120
   Sabio G, 2014, SEMIN IMMUNOL, V26, P237, DOI 10.1016/j.smim.2014.02.009
   Sasayama D, 2013, J PSYCHIATR RES, V47, P401, DOI 10.1016/j.jpsychires.2012.12.001
   Schiller CE, 2013, PHYSIOL BEHAV, V119, P137, DOI 10.1016/j.physbeh.2013.06.009
   Seillet C, 2014, CYTOKINE, V70, P1, DOI 10.1016/j.cyto.2014.06.002
   Shabbir F, 2013, NEUROCHEM INT, V62, P324, DOI 10.1016/j.neuint.2012.12.014
   Sindreu C, 2014, MOL BRAIN, V7, DOI 10.1186/1756-6606-7-16
   Sindreu C, 2011, P NATL ACAD SCI USA, V108, P3366, DOI 10.1073/pnas.1019166108
   Smith Caroline C, 2009, Psychoneuroendocrinology, V34 Suppl 1, pS130, DOI 10.1016/j.psyneuen.2009.06.003
   Song C, 2013, J NEUROINFLAMM, V10, DOI 10.1186/1742-2094-10-59
   Spencer-Segal JL, 2012, NEUROSCIENCE, V202, P131, DOI 10.1016/j.neuroscience.2011.11.035
   Srivastava DP, 2013, NEUROSCIENCE, V239, P17, DOI 10.1016/j.neuroscience.2012.12.004
   Sterner EY, 2010, PROG NEURO-PSYCHOPH, V34, P777, DOI 10.1016/j.pnpbp.2010.03.005
   Stranahan AM, 2011, NEUROENDOCRINOLOGY, V93, P58, DOI 10.1159/000322808
   Suarez EC, 2004, PSYCHONEUROENDOCRINO, V29, P1119, DOI 10.1016/j.psyneuen.2004.01.002
   Swardfager W, 2013, NEUROSCI BIOBEHAV R, V37, P911, DOI 10.1016/j.neubiorev.2013.03.018
   Szatmáry Z, 2004, J BIOL CHEM, V279, P43708, DOI 10.1074/jbc.M406568200
   Szewczyk B, 2013, FRONT AGING NEUROSCI, V5, DOI 10.3389/fnagi.2013.00033
   Tarantino Lisa M, 2011, Front Psychiatry, V2, P44, DOI 10.3389/fpsyt.2011.00044
   Tassabehji NM, 2008, PHYSIOL BEHAV, V95, P365, DOI 10.1016/j.physbeh.2008.06.017
   Toigo EV, 2012, NEUROCHEM RES, V37, P126, DOI 10.1007/s11064-011-0590-3
   Tong LQ, 2008, NEUROBIOL AGING, V29, P1380, DOI 10.1016/j.neurobiolaging.2007.02.027
   Tong LQ, 2012, J NEUROSCI, V32, P17714, DOI 10.1523/JNEUROSCI.1253-12.2012
   Valladolid-Acebes I, 2012, AM J PHYSIOL-ENDOC M, V302, pE396, DOI 10.1152/ajpendo.00343.2011
   Wang RM, 2013, HIPPOCAMPUS, V23, P634, DOI 10.1002/hipo.22126
   Wang X, 2004, MOL PSYCHIATR, V9, P65, DOI 10.1038/sj.mp.4001339
   Wong JHK, 2011, J NEUROENDOCRINOL, V23, P1156, DOI 10.1111/j.1365-2826.2011.02169.x
   Woo J, 2013, LIPIDS HEALTH DIS, V12, DOI 10.1186/1476-511X-12-144
   Wosiski-Kuhn M, 2014, PSYCHONEUROENDOCRINO, V42, P165, DOI 10.1016/j.psyneuen.2014.01.020
   Wrann CD, 2013, CELL METAB, V18, P649, DOI 10.1016/j.cmet.2013.09.008
   Wu A, 2003, NEUROSCIENCE, V119, P365, DOI 10.1016/S0306-4522(03)00154-4
   Xu H, 2011, HIPPOCAMPUS, V21, P495, DOI 10.1002/hipo.20767
   Yamada N, 2011, ENDOCRINOLOGY, V152, P2634, DOI 10.1210/en.2011-0004
   Yang LC, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009851
   Zhang Y, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0072652
NR 140
TC 70
Z9 76
U1 2
U2 24
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD SEP 26
PY 2014
VL 5
AR 136
DI 10.3389/fpsyt.2014.00136
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA V46WA
UT WOS:000209913100001
PM 25309465
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gaston, SA
   Park, YM
   McWhorter, KL
   Sandler, DP
   Jackson, CL
AF Gaston, Symielle A.
   Park, Yong-Moon
   McWhorter, Ketrell L.
   Sandler, Dale P.
   Jackson, Chandra L.
TI Multiple poor sleep characteristics and metabolic abnormalities
   consistent with metabolic syndrome among white, black, and
   Hispanic/Latina women: modification by menopausal status
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Metabolic syndrome; Sleep; African Americans; Hispanic Americans;
   Whites; Women; Menopause
ID PHYSICAL-ACTIVITIES; DURATION; QUALITY; ASSOCIATION; PREVALENCE; ADULTS;
   RISK; RECOMMENDATIONS; DISPARITIES; MANAGEMENT
AB Poor sleep is a potential risk factor for metabolic syndrome (MetS), and its relationship with MetS may vary by race/ethnicity and menopausal status among women.
   We used Sister Study enrollment data from 2003 to 2009 to investigate the cross-sectional associations between multiple subjective sleep characteristics and having ae 3 prevalent metabolic abnormalities consistent with MetS among white, black, and Hispanic/Latina women. Self-reported sleep characteristics included average sleep duration (short [< 7 h] vs. recommended [7-9 h]), sleep debt (ae 2-h difference between shortest and longest sleep duration, napping ae<yen> 3 times/week, and insomnia symptoms (difficulty falling or staying asleep). We used Poisson regression with robust variance to estimate adjusted prevalence ratios (PRs) and 95% confidence intervals (CIs) to compare MetS prevalence between women with poor sleep (e.g., short sleep, sleep debt, frequent napping, or insomnia symptoms [all yes vs. no]) and non-poor sleep within menopausal status categories (premenopausal or postmenopausal). We adjusted for sociodemographic characteristics, mental health, and health behaviors.
   Among 38,007 eligible women (13,988 premenopausal, 24,019 postmenopausal), mean age was 55 +/- 8.8 years, racial/ethnic composition was 86.63% white, 8.53% black, and 4.84% Hispanic/Latina, and 12% had MetS. Associations between certain poor sleep characteristics [i.e., short sleep (PRpremenopausal = 1.23 [95% CI 1.06-1.42], PRpostmenopausal = 1.09 [1.02-1.16], p(short sleep*menopause) = 0.0070) and insomnia symptoms (PRpremenopausal = 1.21 [1.05-1.41], PRpostmenopausal = 1.11 [1.05-1.18], p(insomnia symptoms*menopause) = 0.035)] and prevalent MetS were stronger among premenopausal compared to postmenopausal women, but did not vary by race/ethnicity. Associations between concurrent short sleep/insomnia symptoms and MetS were stronger among white and Hispanic/Latina postmenopausal women compared to their black counterparts. Menopausal status and race/ethnicity did not modify positive associations for other poor sleep characteristics.
   Poor sleep was positively associated with MetS prevalence. Associations between individual poor sleep characteristics (i.e., short sleep, insomnia symptoms) were stronger among premenopausal compared to postmenopausal women but did not vary by race/ethnicity.
C1 [Gaston, Symielle A.; Park, Yong-Moon; McWhorter, Ketrell L.; Sandler, Dale P.; Jackson, Chandra L.] NIEHS, Epidemiol Branch, Dept Hlth & Human Serv, NIH, Res Triangle Pk, NC 27709 USA.
   [Jackson, Chandra L.] Natl Inst Minor Hlth & Hlth Dispar, Intramural Program, US Dept HHS, NIH, Bethesda, MD USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Environmental Health Sciences (NIEHS); National Institutes of Health
   (NIH) - USA; NIH National Institute on Minority Health & Health
   Disparities (NIMHD)
RP Jackson, CL (corresponding author), NIEHS, Epidemiol Branch, Dept Hlth & Human Serv, NIH, Res Triangle Pk, NC 27709 USA.
EM symielle.gaston@nih.gov; mark.park@nih.gov; ketrell.mcwhorter@nih.gov;
   sandler@niehs.nih.gov; chandra.jackson@nih.gov
RI Gaston, Symielle/R-2695-2019; Sandler, Dale/E-5110-2019; PARK, YONG-MOON
   ("MARK")/ABA-2765-2021; Jackson, Chandra/A-6291-2017
OI Sandler, Dale/0000-0002-6776-0018; Gaston, Symielle/0000-0001-9495-1592;
   Jackson, Chandra/0000-0002-0915-8272; PARK, YONG-MOON
   ("MARK")/0000-0002-5879-6879
FU Intramural Program at the NIH, National Institute of Environmental
   Health Sciences [Z1AES103325-01, Z01ES044005]; National Institute of
   Environmental Health Sciences [ZIAES103325] Funding Source: NIH RePORTER
FX This work was funded by the Intramural Program at the NIH, National
   Institute of Environmental Health Sciences [Z1AES103325-01 (CLJ) and
   Z01ES044005 (DPS)].
CR AINSWORTH BE, 1993, MED SCI SPORT EXER, V25, P71, DOI 10.1249/00005768-199301000-00011
   Ainsworth BE, 2000, MED SCI SPORT EXER, V32, pS498, DOI 10.1097/00005768-200009001-00009
   Atkinson FS, 2008, DIABETES CARE, V31, P2281, DOI 10.2337/dc08-1239
   Baker FC, 2018, NAT SCI SLEEP, V10, P73, DOI 10.2147/NSS.S125807
   Barros Aluisio J D, 2003, BMC Med Res Methodol, V3, P21, DOI 10.1186/1471-2288-3-21
   Benjamin EJ, 2018, CIRCULATION, V137, pE67, DOI [10.1161/CIR.0000000000000485, 10.1161/CIR.0000000000000558, 10.1161/CIR.0000000000000530]
   BLOCK G, 1986, AM J EPIDEMIOL, V124, P453, DOI 10.1093/oxfordjournals.aje.a114416
   Buxton OM, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3003200
   Calonge N, 2004, AM FAM PHYSICIAN, V69, P1973
   Cappuccio FP, 2008, SLEEP, V31, P619, DOI 10.1093/sleep/31.5.619
   Chaput JP, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0072832
   Choi JK, 2011, TOHOKU J EXP MED, V225, P187, DOI 10.1620/tjem.225.187
   Freedman RR, 2014, MENOPAUSE, V21, P534, DOI 10.1097/GME.0000000000000243
   Gómez-Santos C, 2016, MENOPAUSE, V23, P682, DOI 10.1097/GME.0000000000000612
   Grandner MA, 2016, SLEEP MED, V18, P7, DOI 10.1016/j.sleep.2015.01.020
   Grandner MA, 2010, SLEEP MED, V11, P470, DOI 10.1016/j.sleep.2009.10.006
   Greenland S, 1999, EPIDEMIOLOGY, V10, P37, DOI 10.1097/00001648-199901000-00008
   Guenther PM, 2014, J NUTR, V144, P399, DOI 10.3945/jn.113.183079
   Hall MH, 2012, SLEEP, V35, P783, DOI 10.5665/sleep.1874
   Heinzer R, 2018, SLEEP MED, V51, P29, DOI 10.1016/j.sleep.2018.04.016
   Hirshkowitz M, 2015, SLEEP HEALTH, V1, P40, DOI 10.1016/j.sleh.2014.12.010
   Hung HS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0065738
   Iftikhar IH, 2015, ANN AM THORAC SOC, V12, P1364, DOI 10.1513/AnnalsATS.201504-190OC
   Jackson CL, 2018, SLEEP, V41, DOI 10.1093/sleep/zsy057
   Jackson CL, 2017, SLEEP HEALTH, V3, P401, DOI 10.1016/j.sleh.2017.08.001
   Jackson CL, 2015, ANNU REV PUBL HEALTH, V36, P417, DOI 10.1146/annurev-publhealth-031914-122838
   Kim JY, 2015, SLEEP MED, V16, P1511, DOI 10.1016/j.sleep.2015.06.024
   Koren D, 2016, DIABETES METAB SYNDR, V9, P281, DOI 10.2147/DMSO.S95120
   Lauderdale DS, 2008, EPIDEMIOLOGY, V19, P838, DOI 10.1097/EDE.0b013e318187a7b0
   Lee J, 2013, TOHOKU J EXP MED, V231, P281, DOI 10.1620/tjem.231.281
   Lin SC, 2016, SLEEP, V39, P1261, DOI 10.5665/sleep.5848
   Liu Y, 2016, MMWR-MORBID MORTAL W, V65, P137, DOI 10.15585/mmwr.mm6506a1
   Mesas AE, 2014, DIABETES-METAB RES, V30, P222, DOI 10.1002/dmrr.2480
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   NCHS, 2017, HLTH US HLTH U STATE
   Okubo N, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-562
   Pu D, 2017, CLIMACTERIC, V20, P583, DOI 10.1080/13697137.2017.1386649
   REAVEN GM, 1993, ANNU REV MED, V44, P121, DOI 10.1146/annurev.med.44.1.121
   Sandler DP, 2017, ENVIRON HEALTH PERSP, V125, DOI 10.1289/EHP1923
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Troxel WM, 2010, SLEEP, V33, P1633, DOI 10.1093/sleep/33.12.1633
   Van Cauter E, 2008, SLEEP MED, V9, pS23, DOI 10.1016/S1389-9457(08)70013-3
   van Dijk GM, 2015, MATURITAS, V80, P24, DOI 10.1016/j.maturitas.2014.09.013
   Whelton PK, 2018, J AM COLL CARDIOL, V71, pE127, DOI 10.1016/j.jacc.2017.11.006
   Xi B, 2014, SLEEP MED REV, V18, P293, DOI 10.1016/j.smrv.2013.06.001
   Yoo H, 2013, J OCCUP ENVIRON MED, V55, P111, DOI 10.1097/JOM.0b013e31826e294c
   Zohal M, 2017, DIABETES METAB SYND, V11, pS377, DOI 10.1016/j.dsx.2017.03.020
NR 48
TC 30
Z9 32
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD FEB 14
PY 2019
VL 11
AR 17
DI 10.1186/s13098-019-0413-2
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HL9TS
UT WOS:000459086100001
PM 30815038
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Venturini, D
   Simao, ANC
   Urbano, MR
   Dichi, I
AF Venturini, Danielle
   Colado Simao, Andrea Name
   Urbano, Mariana Ragassi
   Dichi, Isaias
TI Effects of extra virgin olive oil and fish oil on lipid profile and
   oxidative stress in patients with metabolic syndrome
SO NUTRITION
LA English
DT Article
DE Metabolic syndrome; Olive oil; Fish oil; Lipid profile; Oxidative stress
ID N-3 FATTY-ACIDS; TOTAL ANTIOXIDANT CAPACITY; DISEASE RISK-FACTORS;
   MEDITERRANEAN DIET; CARDIOVASCULAR-DISEASE; PRIMARY PREVENTION; PROTEIN
   PRODUCTS; BLOOD-PRESSURE; SERUM-LIPIDS; URIC-ACID
AB Objective: The aim of this study was to verify if extra virgin olive oil and fish oil have a synergistic effect on lipid and oxidative stress parameters in patients with metabolic syndrome (MetS).
   Methods: This intervention study included 102 patients (81 women and 21 men) with MetS (mean age 51.45 +/- 8.27 y) from the ambulatory center of the University Hospital of Londrina, Parana, Brazil. Patients were randomly assigned to one of four groups: Patients in the control group (CG) were instructed to maintain their usual diet; the second group (fish oil group [FO]) received 3 g/d of fish oil omega-3 fatty acids (10 capsules); the third group (extra virgin olive oil group [00]) received 10 mL/d of extra virgin olive oil at lunch and dinner; and the fourth group (fish oil and extra virgin olive oil group [FOO]) received 3 g/d of fish oil omega-3 fatty acids and 10 mL/d of extra virgin olive oil. MetS related markers and oxidative stress were measured at baseline and after 90 d.
   Results: Differences across treatment groups showed a statistically significant decrease (P < 0.05) in total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) when FOO was compared with CG and OO, respectively. Hydroperoxides showed a significant decrease (P < 0.05) when FOO was compared with CG, whereas there was an increase in total peroxyl radical-trapping antioxidant potential/advanced oxidation protein products (TRAP/AOPP; P < 0.05) in FOO when compared with FO. In relation to baseline values, there was a significant decrease (P < 0.05) in LDL-C values, and TC/high-density lipoprotein cholesterol (HDL-C) and LDL-C/HDL-C indexes in FOO. There was also a decrease (P < 0.05) in hydroperoxides, in AOPP and in AOPP/TRAP index in FOO, and an increase (P < 0.05) in TRAP/AOPP index in FOO and in TRAP/uric acid ratio in OO.
   Conclusion: The present study provides evidence that increased dietary omega-3 polyunsaturated fatty acids and extra virgin olive oil have beneficial synergistic effects on lipid metabolism and oxidative stress in patients with MetS. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Venturini, Danielle; Colado Simao, Andrea Name] Univ Londrina, Dept Pathol Clin Anal & Toxicol, Londrina, Parana, Brazil.
   [Urbano, Mariana Ragassi] Univ Londrina, Dept Stat, Londrina, Parana, Brazil.
   [Dichi, Isaias] Univ Londrina, Dept Internal Med, Londrina, Parana, Brazil.
RP Venturini, D (corresponding author), Univ Londrina, Dept Pathol Clin Anal & Toxicol, Londrina, Parana, Brazil.
EM Dichi@sercomtel.com.br
RI Venturini, Danielle/HPH-1330-2023; Urbano, Mariana/AAQ-5622-2021; Simão,
   Andrea/AAM-4892-2021
OI Urbano, Mariana/0000-0002-5411-5554
CR Al-Gubory KH, 2012, INT J BIOCHEM CELL B, V44, P1569, DOI 10.1016/j.biocel.2012.06.003
   Barzi F, 2003, EUR J CLIN NUTR, V57, P1034, DOI 10.1038/sj.ejcn.1601575
   Belalcazar LM, 2009, DIABETES CARE, V33, P197
   Berbert AA, 2005, NUTRITION, V21, P131, DOI 10.1016/j.nut.2004.03.023
   Bondia-Pons I, 2007, J NUTR, V137, P84, DOI 10.1093/jn/137.1.84
   Buckland G, 2011, BRIT J NUTR, V106, P1581, DOI 10.1017/S0007114511002078
   Carluccioll MA, 2007, MOL NUTR FOOD RES, V51, P1225, DOI 10.1002/mnfr.200600305
   Castañer O, 2012, AM J CLIN NUTR, V95, P1238, DOI 10.3945/ajcn.111.029207
   Simao ANC, 2008, NUTRITION, V24, P675, DOI 10.1016/j.nut.2008.03.021
   Simao ANC, 2014, NUTRITION, V30, P112, DOI 10.1016/j.nut.2013.05.024
   Simáo ANC, 2012, EXPERT OPIN THER TAR, V16, P1175, DOI 10.1517/14728222.2012.723694
   Simao ANC, 2012, BRIT J NUTR, V108, P1435, DOI 10.1017/S0007114511006921
   Simao ANC, 2010, ARQ BRAS ENDOCRINOL, V54, P463, DOI 10.1590/S0004-27302010000500006
   Covas MI, 2006, ANN INTERN MED, V145, P333, DOI 10.7326/0003-4819-145-5-200609050-00006
   Crawford M, 2000, ANN NUTR METAB, V44, P263, DOI 10.1159/000046694
   Crnkovic S, 2012, FREE RADICAL BIO MED, V52, P1786, DOI 10.1016/j.freeradbiomed.2012.02.036
   Damsgaard CT, 2008, J NUTR, V138, P1061, DOI 10.1093/jn/138.6.1061
   De Caterina R, 2007, DIABETES CARE, V30, P1012, DOI 10.2337/dc06-1332
   Eckel RH, 2010, LANCET, V375, P181, DOI 10.1016/S0140-6736(09)61794-3
   Estruch R, 2013, NEW ENGL J MED, V368, P1279, DOI 10.1056/NEJMoa1200303
   Estruch R, 2006, ANN INTERN MED, V145, P1, DOI 10.7326/0003-4819-145-1-200607040-00004
   Fitó M, 2000, LIPIDS, V35, P633, DOI 10.1007/s11745-000-0567-1
   FLECHA BG, 1991, FREE RADICAL BIO MED, V10, P93
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Grundy SM, 2004, CIRCULATION, V110, P227, DOI 10.1161/01.CIR.0000133317.49796.0E
   Haffner SM, 2003, AM J CARDIOL, V92, p18J, DOI 10.1016/S0002-9149(03)00612-X
   Harris WS, 2009, CIRCULATION, V119, P902, DOI 10.1161/CIRCULATIONAHA.108.191627
   Kastorini CM, 2011, J AM COLL CARDIOL, V57, P1299, DOI 10.1016/j.jacc.2010.09.073
   Kesavulu MM, 2001, DIABETES RES CLIN PR, V53, P33, DOI 10.1016/S0168-8227(01)00238-8
   Konstantinidou V, 2010, FASEB J, V24, P2546, DOI 10.1096/fj.09-148452
   Lara JJ, 2007, ATHEROSCLEROSIS, V193, P213, DOI 10.1016/j.atherosclerosis.2006.06.018
   Liem AH, 2008, CURR MED RES OPIN, V24, P359, DOI 10.1185/030079907X253906
   Mangas-Cruz MA, 2001, CLIN NUTR, V20, P211, DOI 10.1054/clnu.2000.0382
   McAnulty SR, 2010, MED SCI SPORT EXER, V42, P1704, DOI 10.1249/MSS.0b013e3181d85bd1
   Melo José Ulisses de Souza, 2010, Rev. Col. Bras. Cir., V37, P351, DOI 10.1590/S0100-69912010000500008
   Mensink RP, 2003, AM J CLIN NUTR, V77, P1146, DOI 10.1093/ajcn/77.5.1146
   Minich DM, 2008, NUTR REV, V66, P429, DOI 10.1111/j.1753-4887.2008.00075.x
   Oikawa S, 2009, ATHEROSCLEROSIS, V206, P535, DOI 10.1016/j.atherosclerosis.2009.03.029
   Pérez-Jiménez F, 2007, MOL NUTR FOOD RES, V51, P1199, DOI [10.1002/mnfr.200600273, 10.1002/mnfr.200790023]
   Repetto M, 1996, CLIN CHIM ACTA, V255, P107, DOI 10.1016/0009-8981(96)06394-2
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Ruano J, 2005, J AM COLL CARDIOL, V46, P1864, DOI 10.1016/j.jacc.2005.06.078
   Ruidavets JB, 2007, J EPIDEMIOL COMMUN H, V61, P810, DOI 10.1136/jech.2006.052126
   Saito Y, 2008, ATHEROSCLEROSIS, V200, P135, DOI 10.1016/j.atherosclerosis.2008.06.003
   Samaniego-Sanchez C, 2010, ANTIOXIDANT CAPACITY, P915
   Saravanan P, 2010, LANCET, V376, P540, DOI 10.1016/S0140-6736(10)60445-X
   Schmidt S, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-45
   Shi XY, 2008, ENDOCRINOLOGY, V149, P1829, DOI 10.1210/en.2007-1544
   Skalicky J, 2008, CLIN CHEM LAB MED, V46, P499, DOI 10.1515/CCLM.2008.096
   Venturini D, 2012, OBESITY, V20, P2361, DOI 10.1038/oby.2012.130
   Vincent-Baudry S, 2005, AM J CLIN NUTR, V82, P964, DOI 10.1093/ajcn/82.5.964
   VISIOLI F, 1995, ATHEROSCLEROSIS, V117, P25, DOI 10.1016/0021-9150(95)05546-9
   WitkoSarsat V, 1996, KIDNEY INT, V49, P1304, DOI 10.1038/ki.1996.186
   Yashodhara BM, 2009, POSTGRAD MED J, V85, P84, DOI 10.1136/pgmj.2008.073338
   Zamora-Ros R, 2013, NUTR METAB CARDIOVAS, V23, P1167, DOI 10.1016/j.numecd.2012.12.008
   Zuliani G, 2009, CURR PHARM DESIGN, V15, P4087, DOI 10.2174/138161209789909773
NR 56
TC 75
Z9 81
U1 0
U2 34
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD JUN
PY 2015
VL 31
IS 6
BP 834
EP 840
DI 10.1016/j.nut.2014.12.016
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CH9GB
UT WOS:000354342900009
PM 25933490
DA 2025-06-11
ER

PT J
AU Vita, A
   Barlati, S
   Cavallaro, R
   Mucci, A
   Riva, MA
   Rocca, P
   Rossi, A
   Galderisi, S
AF Vita, Antonio
   Barlati, Stefano
   Cavallaro, Roberto
   Mucci, Armida
   Riva, Marco A.
   Rocca, Paola
   Rossi, Alessandro
   Galderisi, Silvana
TI Definition, assessment and treatment of cognitive impairment associated
   with schizophrenia: expert opinion and practical recommendations
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE CIAS; cognitive impairment; cognitive remediation; evidence-based;
   psychosocial functioning; psychosocial rehabilitation; schizophrenia;
   social cognition
ID DIRECT-CURRENT STIMULATION; SOCIAL COGNITION; METABOLIC SYNDROME;
   SPECTRUM DISORDERS; NEGATIVE SYMPTOMS; DOUBLE-BLIND; LONG-TERM;
   FOLLOW-UP; ANTICHOLINERGIC BURDEN; SUBSTANCE USE
AB A considerable proportion of patients with schizophrenia perform below population norms on standardized neuropsychological tests, and the performance of those performing within normal range is lower than predicted based on parental education. Cognitive impairment predates the onset of psychosis, is observed during symptom remission and in non-affected first-degree relatives of patients. At the present time, cognitive deficits are regarded as key features of schizophrenia, important determinants of poor psychosocial outcome and targets for both pharmacological and non-pharmacological treatment strategies. A group of eight key opinion leaders reviewed and discussed latest advances in scientific research and current good clinical practices on assessment, management, and treatment of CIAS. In the present paper they summarize the current evidence, identify main gaps between current knowledge and mental health services clinical practice, and provide practical recommendations to reduce the gap.
C1 [Vita, Antonio; Barlati, Stefano] Univ Brescia, Dept Clin & Expt Sci, Brescia, Italy.
   [Vita, Antonio; Barlati, Stefano] Azienda Socio Sanit Territoriale ASST Spedali Civi, Dept Mental Hlth & Addict Serv, Brescia, Italy.
   [Cavallaro, Roberto] Ist Sci San Raffaele, Sci Inst Res Hospitalizat & Healthcare IRCCS, Dept Clin Neurosci, Milan, Italy.
   [Cavallaro, Roberto] Univ Vita Salute San Raffaele, Sch Med, Milan, Italy.
   [Mucci, Armida; Galderisi, Silvana] Univ Campania Luigi Vanvitelli, Dept Mental & Phys Hlth & Prevent Med, Naples, Italy.
   [Riva, Marco A.] Univ Milan, Dept Pharmacol & Biomol Sci, Milan, Italy.
   [Riva, Marco A.] Sci Inst Res Hospitalizat & Healthcare IRCCS, Ist Ctr San Giovanni Dio Fatebenefratelli, Biol Psychiat Unit, Brescia, Italy.
   [Rocca, Paola] Univ Turin, Dept Neurosci Rita Levi Montalcini, Turin, Italy.
   [Rossi, Alessandro] Univ Aquila, Dept Biotechnol & Appl Clin Sci, Sect Psychiat, Laquila, Italy.
C3 University of Brescia; Vita-Salute San Raffaele University; IRCCS
   Ospedale San Raffaele; Vita-Salute San Raffaele University; Universita
   della Campania Vanvitelli; University of Milan; IRCCS Fatebenefratelli;
   University of Turin; University of L'Aquila
RP Barlati, S (corresponding author), Univ Brescia, Dept Clin & Expt Sci, Brescia, Italy.; Barlati, S (corresponding author), Azienda Socio Sanit Territoriale ASST Spedali Civi, Dept Mental Hlth & Addict Serv, Brescia, Italy.
EM stefano.barlati@unibs.it
RI Barlati, Stefano/M-2992-2017; Rocca, Paola/IIS-9400-2023; Vita,
   Antonio/K-4345-2018; Mucci, Armida/JDM-7796-2023; Riva, Marco
   Andrea/JAC-8536-2023
OI Vita, Antonio/0000-0002-3621-6394
FU Angelini Pharma
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. The authors
   declare that this study received funding from Angelini Pharma. The
   funder was not involved in the study design, collection, analysis,
   interpretation of data, the writing of this article, or the decision to
   submit it for publication.r The author(s) declare that financial support
   was received for the research, authorship, and/or publication of this
   article. The authors declare that this study received funding from
   Angelini Pharma. The funder was not involved in the study design,
   collection, analysis, interpretation of data, the writing of this
   article, or the decision to submit it for publication.
CR Abu-Akel A, 2022, MOL PSYCHIATR, V27, P2976, DOI 10.1038/s41380-022-01543-5
   Adamowicz K, 2020, J CLIN MED, V9, DOI 10.3390/jcm9020537
   Ahmed AO, 2018, PSYCHIAT RES, V259, P350, DOI 10.1016/j.psychres.2017.11.003
   Alsuhaibani R, 2021, BMC PSYCHIATRY, V21, DOI 10.1186/s12888-021-03188-0
   Ang MS, 2017, J CLIN PSYCHOPHARM, V37, P651, DOI 10.1097/JCP.0000000000000790
   Baldez DP, 2021, NEUROSCI BIOBEHAV R, V126, P265, DOI 10.1016/j.neubiorev.2021.03.028
   Barker MJ, 2004, CNS DRUGS, V18, P37, DOI 10.2165/00023210-200418010-00004
   Barlati S, 2023, EUR ARCH PSY CLIN N, V273, P1307, DOI 10.1007/s00406-022-01510-9
   Barlati S, 2022, SCHIZOPHR RES, V250, P31, DOI 10.1016/j.schres.2022.10.002
   Barlati S, 2012, CURR PHARM DESIGN, V18, P534, DOI 10.2174/138161212799316091
   Bechi M, 2021, J PSYCHIATR RES, V137, P48, DOI 10.1016/j.jpsychires.2021.02.044
   Bechi M, 2020, SCHIZOPHR RES-COGN, V19, DOI 10.1016/j.scog.2019.100164
   Begemann MJ, 2020, PSYCHOL MED, V50, P2465, DOI 10.1017/S0033291720003670
   BENTALL RP, 1990, PSYCHOL BULL, V107, P82, DOI 10.1037/0033-2909.107.1.82
   Bergh S, 2016, SCHIZOPHR RES, V175, P57, DOI 10.1016/j.schres.2016.03.025
   Bleuler E, 1950, Dementia praecox or the group of schizophrenias
   Bogaty SER, 2018, J PSYCHIATR RES, V99, P22, DOI 10.1016/j.jpsychires.2018.01.010
   Bora E, 2017, PSYCHOL MED, V47, P1030, DOI 10.1017/S0033291716003366
   Bosia M, 2007, NEUROSCI LETT, V417, P271, DOI 10.1016/j.neulet.2007.02.076
   Bosia M, 2014, PSYCHIAT RES, V217, P9, DOI 10.1016/j.psychres.2014.02.015
   Bourque J, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.596601
   Bowie CR, 2020, SCHIZOPHR RES, V215, P49, DOI 10.1016/j.schres.2019.10.047
   Brannan SK, 2021, NEW ENGL J MED, V384, P717, DOI 10.1056/NEJMoa2017015
   Bryce S, 2018, PSYCHIATR REHABIL J, V41, P302, DOI 10.1037/prj0000309
   Bryson G, 1997, PSYCHIAT RES, V71, P105, DOI 10.1016/S0165-1781(97)00050-4
   Bucci P, 2023, EUR ARCH PSY CLIN N, DOI 10.1007/s00406-023-01641-7
   Buckley PF, 2009, SCHIZOPHRENIA BULL, V35, P383, DOI 10.1093/schbul/sbn135
   Burschinski A, 2023, WORLD PSYCHIATRY, V22, P116, DOI 10.1002/wps.21036
   Çakici N, 2019, PSYCHOL MED, V49, P2307, DOI 10.1017/S0033291719001995
   Caligiuri SPB, 2018, NEUROPSYCHOPHARMACOL, V43, P223, DOI 10.1038/npp.2017.197
   Cantor-Graae E, 2001, SCHIZOPHR RES, V48, P69, DOI 10.1016/S0920-9964(00)00114-6
   Carruthers SP, 2021, SLEEP MED, V84, P8, DOI 10.1016/j.sleep.2021.05.011
   Carruthers SP, 2019, NEUROSCI BIOBEHAV R, V107, P252, DOI 10.1016/j.neubiorev.2019.09.006
   Chiu VW, 2016, PSYCHIAT QUART, V87, P633, DOI 10.1007/s11126-015-9415-x
   Cho M, 2019, AUST NZ J PSYCHIAT, V53, P742, DOI 10.1177/0004867419835028
   Clissold M, 2019, J CLIN EXP NEUROPSYC, V41, P26, DOI 10.1080/13803395.2018.1488952
   CORCORAN R, 1995, SCHIZOPHR RES, V17, P5, DOI 10.1016/0920-9964(95)00024-G
   Corponi F, 2019, EUR NEUROPSYCHOPHARM, V29, P971, DOI 10.1016/j.euroneuro.2019.06.008
   Correll CU, 2007, CNS SPECTRUMS, V12, P12, DOI 10.1017/S1092852900026298
   Correll CU, 2022, WORLD PSYCHIATRY, V21, P248, DOI 10.1002/wps.20994
   Correll CU, 2017, JAMA PSYCHIAT, V74, P675, DOI 10.1001/jamapsychiatry.2017.0624
   Cortes-Briones JA, 2022, SCHIZOPHR RES, V245, P122, DOI 10.1016/j.schres.2021.05.018
   Crump C, 2013, AM J PSYCHIAT, V170, P324, DOI 10.1176/appi.ajp.2012.12050599
   Dai YY, 2022, SCHIZOPHRENIA-UK, V8, DOI 10.1038/s41537-022-00297-x
   Das S, 2016, THER ADV PSYCHOPHARM, V6, P39, DOI 10.1177/2045125315614739
   Dauwan M, 2016, SCHIZOPHRENIA BULL, V42, P588, DOI 10.1093/schbul/sbv164
   de Bartolomeis A, 2022, PHARMACOL RES, V176, DOI 10.1016/j.phrs.2022.106078
   De Berardis D, 2021, BRAIN SCI, V11, DOI 10.3390/brainsci11020275
   Demirlek C, 2023, SCHIZOPHR RES, V254, P146, DOI 10.1016/j.schres.2023.02.028
   Désaméricq G, 2014, EUR J CLIN PHARMACOL, V70, P127, DOI 10.1007/s00228-013-1600-y
   Deste G, 2023, BRAIN SCI, V13, DOI 10.3390/brainsci13020320
   Deste G, 2020, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.00524
   Dik MG, 2007, DIABETES CARE, V30, P2655, DOI 10.2337/dc06-1190
   Dixon TA, 2023, MOL PSYCHIATR, V28, P83, DOI 10.1038/s41380-022-01708-2
   Drake RE, 2006, SCHIZOPHRENIA BULL, V32, P464, DOI 10.1093/schbul/sbj064
   Duan JB, 2015, NEUROSCI BULL, V31, P113, DOI 10.1007/s12264-014-1488-2
   Eum S, 2021, NEUROPSYCHOPHARMACOL, V46, P1802, DOI 10.1038/s41386-021-01057-8
   Eum S, 2017, SCHIZOPHR RES, V190, P129, DOI 10.1016/j.schres.2017.03.034
   Evans J, 2023, SCHIZOPHRENIA-UK, V9, DOI 10.1038/s41537-023-00390-9
   Farruggia MC, 2019, PHYSIOL BEHAV, V208, DOI 10.1016/j.physbeh.2019.112578
   Feber L, 2023, SYST REV-LONDON, V12, DOI 10.1186/s13643-023-02213-5
   Fernández-Abascal B, 2021, NEUROSCI BIOBEHAV R, V125, P535, DOI 10.1016/j.neubiorev.2021.01.005
   Fett AKJ, 2022, SCHIZOPHR RES-COGN, V28, DOI 10.1016/j.scog.2022.100237
   Fett AKJ, 2020, JAMA PSYCHIAT, V77, P387, DOI 10.1001/jamapsychiatry.2019.3993
   Fiorillo A, 2021, ANN GEN PSYCHIATR, V20, DOI 10.1186/s12991-021-00374-y
   Firth J, 2017, SCHIZOPHRENIA BULL, V43, P546, DOI 10.1093/schbul/sbw115
   Fleischhacker W, 2019, EUR PSYCHIAT, V58, P1, DOI 10.1016/j.eurpsy.2019.01.015
   Fond G, 2018, EUR ARCH PSY CLIN N, V268, P17, DOI 10.1007/s00406-017-0787-9
   Fradley R, 2023, NEUROCHEM RES, V48, P3027, DOI 10.1007/s11064-023-03956-2
   Frazer KM, 2018, BEHAV BRAIN RES, V348, P241, DOI 10.1016/j.bbr.2018.04.005
   Fridell M, 2019, BMC PSYCHIATRY, V19, DOI 10.1186/s12888-019-2098-3
   Friedman JI, 2001, AM J PSYCHIAT, V158, P1441, DOI 10.1176/appi.ajp.158.9.1441
   Fusar-Poli P, 2012, ARCH GEN PSYCHIAT, V69, P562, DOI 10.1001/archgenpsychiatry.2011.1592
   Galderisi S, 2021, EUR PSYCHIAT, V64, DOI 10.1192/j.eurpsy.2021.13
   Galderisi S, 2021, EUR PSYCHIAT, V64, DOI 10.1192/j.eurpsy.2021.11
   Galderisi S, 2021, EUR PSYCHIAT, V64, DOI 10.1192/j.eurpsy.2020.115
   Galderisi S, 2018, JAMA PSYCHIAT, V75, P396, DOI 10.1001/jamapsychiatry.2017.4607
   Galderisi S, 2016, SCHIZOPHR RES, V175, P154, DOI 10.1016/j.schres.2016.04.043
   Galderisi S, 2014, WORLD PSYCHIATRY, V13, P275, DOI 10.1002/wps.20167
   Galletly C, 2016, AUST NZ J PSYCHIAT, V50, P410, DOI 10.1177/0004867416641195
   Giordano GM, 2022, SCHIZOPHR RES, V241, P161, DOI 10.1016/j.schres.2022.01.029
   Goh KK, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23137092
   González-Castañeda H, 2021, COGENT PSYCHOL, V8, DOI 10.1080/23311908.2021.1913878
   Gott CA, 2023, AUSTRALAS PSYCHIATRY, V31, P584, DOI 10.1177/10398562231186125
   Green AI, 2018, SCHIZOPHR RES, V194, P1, DOI 10.1016/j.schres.2017.10.008
   Green MF, 2008, AM J PSYCHIAT, V165, P221, DOI 10.1176/appi.ajp.2007.07010089
   Green MF, 2019, WORLD PSYCHIATRY, V18, P146, DOI 10.1002/wps.20624
   Grover S, 2019, PSYCHIAT RES, V278, P56, DOI 10.1016/j.psychres.2019.05.023
   Haba-Rubio J, 2017, NEUROLOGY, V88, P463, DOI 10.1212/WNL.0000000000003557
   Habtewold TD, 2020, TRANSL PSYCHIAT, V10, DOI 10.1038/s41398-020-00919-x
   Hagi K, 2021, JAMA PSYCHIAT, V78, P510, DOI 10.1001/jamapsychiatry.2021.0015
   Haime Z, 2021, BMC PSYCHIATRY, V21, DOI 10.1186/s12888-021-03545-z
   Hakobyan S, 2020, J CLIN MED, V9, DOI 10.3390/jcm9082406
   Harvey PD, 2022, SCHIZOPHR RES-COGN, V29, DOI 10.1016/j.scog.2022.100249
   Harvey Philip D, 2016, Schizophr Res Cogn, V5, P7, DOI 10.1016/j.scog.2016.05.002
   Harvey PD, 2015, SCHIZOPHR RES, V166, P334, DOI 10.1016/j.schres.2015.06.008
   Harvey PD, 2014, J CLIN PSYCHIAT, V75, P34, DOI 10.4088/JCP.13065su1.08
   Harvey PD, 2013, EUR NEUROPSYCHOPHARM, V23, P1373, DOI 10.1016/j.euroneuro.2013.08.003
   Harvey PD, 2012, WORLD PSYCHIATRY, V11, P73, DOI 10.1016/j.wpsyc.2012.05.004
   Hjorthoj C, 2017, LANCET PSYCHIAT, V4, P295, DOI 10.1016/S2215-0366(17)30078-0
   Horan WP, 2023, CURR TOP BEHAV NEURO, V63, P407, DOI 10.1007/7854_2022_382
   Hunt GE, 2018, DRUG ALCOHOL DEPEN, V191, P234, DOI 10.1016/j.drugalcdep.2018.07.011
   Iwata Y, 2015, MOL PSYCHIATR, V20, P1151, DOI 10.1038/mp.2015.68
   Jiang Y, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00135
   Joshi YB, 2021, AM J PSYCHIAT, V178, P838, DOI 10.1176/appi.ajp.2020.20081212
   Joyce EM, 2007, CURR OPIN PSYCHIATR, V20, P268
   Kalin M, 2015, J PSYCHIATR RES, V68, P254, DOI 10.1016/j.jpsychires.2015.07.008
   Kambeitz-Ilankovic L, 2019, NEUROSCI BIOBEHAV R, V107, P828, DOI 10.1016/j.neubiorev.2019.09.031
   Kaul I, 2024, LANCET, V403, P160, DOI 10.1016/S0140-6736(23)02190-6
   Keech B, 2018, PSYCHONEUROENDOCRINO, V87, P9, DOI 10.1016/j.psyneuen.2017.09.022
   Keefe RSE, 2004, SCHIZOPHR RES, V68, P283, DOI 10.1016/j.schres.2003.09.011
   Keepers GA, 2020, AM J PSYCHIAT, V177, P868, DOI [10.1176/appi.ajp.2020.177901, 10.1176/appi.focus.18402]
   Kern RS, 2008, AM J PSYCHIAT, V165, P214, DOI 10.1176/appi.ajp.2007.07010043
   Kern RS, 2004, SCHIZOPHR RES, V72, P11, DOI 10.1016/j.schres.2004.09.004
   Khan WU, 2021, SCHIZOPHRENIA BULL, V47, P259, DOI 10.1093/schbul/sbaa093
   Killaspy H, 2021, BMJ-BRIT MED J, V372, DOI 10.1136/bmj.n1
   Kirschner M, 2017, SCHIZOPHR RES, V186, P29, DOI 10.1016/j.schres.2016.05.003
   Kishi T, 2017, PSYCHOPHARMACOLOGY, V234, P2113, DOI 10.1007/s00213-017-4616-7
   Kostova R, 2020, SCHIZOPHR RES, V220, P300, DOI 10.1016/j.schres.2020.03.002
   Kraepelin E., 1919, Dementia Praecox and Paraphrenia
   Lai JW, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18116099
   Lambert M, 2005, ACTA PSYCHIAT SCAND, V112, P141, DOI 10.1111/j.1600-0447.2005.00554.x
   Large M, 2014, AUST NZ J PSYCHIAT, V48, P418, DOI 10.1177/0004867414525838
   Laszlovszky I, 2021, ADV THER, V38, P3652, DOI 10.1007/s12325-021-01797-5
   Lejeune JA, 2021, SCHIZOPHRENIA BULL, V47, P997, DOI 10.1093/schbul/sbab022
   Leucht S, 2017, AM J PSYCHIAT, V174, P927, DOI 10.1176/appi.ajp.2017.16121358
   Lindenmayer JP, 2012, SCHIZOPHR RES, V142, P171, DOI 10.1016/j.schres.2012.09.019
   Lisoni J, 2022, J PSYCHIATR RES, V155, P430, DOI 10.1016/j.jpsychires.2022.09.011
   Liu X, 2022, PSYCHIAT RES, V308, DOI 10.1016/j.psychres.2021.114330
   Lovell ME, 2020, EXP CLIN PSYCHOPHARM, V28, P471, DOI 10.1037/pha0000326
   Lynskey MT, 2015, LANCET PSYCHIAT, V2, P767, DOI 10.1016/S2215-0366(15)00372-7
   Lysaker PH, 2018, WORLD J PSYCHIATR, V8, P1, DOI 10.5498/wjp.v8.i1.1
   Lysaker PH, 2005, ACTA PSYCHIAT SCAND, V112, P64, DOI 10.1111/j.1600-0447.2005.00514.x
   Lysaker PH, 2002, PSYCHIATRY, V65, P197, DOI 10.1521/psyc.65.3.197.20174
   Maj M, 2021, WORLD PSYCHIATRY, V20, P4, DOI 10.1002/wps.20809
   Marder Stephen R, 2006, Dialogues Clin Neurosci, V8, P109
   Mayeli A, 2023, MOL PSYCHIATR, V28, P2049, DOI 10.1038/s41380-023-02050-x
   Mazereel V, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.573479
   McCleery A, 2014, SCHIZOPHR RES, V157, P33, DOI 10.1016/j.schres.2014.04.039
   McCleery A, 2019, DIALOGUES CLIN NEURO, V21, P239, DOI 10.31887/DCNS.2019.21.3/amccleery
   McCleery A, 2016, SCHIZOPHR RES, V176, P467, DOI 10.1016/j.schres.2016.07.008
   McCoy JG, 2011, NEUROBIOL LEARN MEM, V96, P564, DOI 10.1016/j.nlm.2011.07.004
   McCutcheon RA, 2023, MOL PSYCHIATR, V28, P1902, DOI 10.1038/s41380-023-01949-9
   McDonald S, 2003, J HEAD TRAUMA REHAB, V18, P219, DOI 10.1097/00001199-200305000-00001
   McIntyre RS, 2022, J PATIENT-REP OUTCOM, V6, DOI 10.1186/s41687-022-00468-5
   Mednova IA, 2020, METABOLITES, V10, DOI 10.3390/metabo10100410
   Meyer N, 2020, SCHIZOPHRENIA BULL, V46, P1126, DOI 10.1093/schbul/sbaa024
   Minor KS, 2014, SCHIZOPHR RES, V159, P198, DOI 10.1016/j.schres.2014.08.005
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Molina JD, 2021, CURR PHARM DESIGN, V27, P4049, DOI 10.2174/1381612827666210804110139
   Mollon J, 2018, PSYCHOL MED, V48, P392, DOI 10.1017/S0033291717001970
   Montemagni C, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.649737
   Moritz S, 2018, SCHIZOPHR RES, V201, P20, DOI 10.1016/j.schres.2018.06.001
   Mosolov SN, 2022, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.766692
   Mucci A, 2021, JAMA PSYCHIAT, V78, P550, DOI 10.1001/jamapsychiatry.2020.4614
   Murri MB, 2020, SCHIZOPHR RES, V218, P188, DOI 10.1016/j.schres.2020.01.005
   Murthy P, 2019, CURR OPIN PSYCHIATR, V32, P293, DOI 10.1097/YCO.0000000000000510
   Nascimento JM, 2022, CELL BIOSCI, V12, DOI 10.1186/s13578-022-00928-x
   Nemoto T, 2021, EARLY INTERV PSYCHIA, V15, P457, DOI 10.1111/eip.12955
   Nibbio G, 2022, FRONT PSYCHIATRY, V13, DOI 10.3389/fpsyt.2022.934005
   Nibbio G, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17103352
   Nuechterlein KH, 2008, AM J PSYCHIAT, V165, P203, DOI 10.1176/appi.ajp.2007.07010042
   Nuechterlein KH, 2023, PSYCHOL MED, V53, P4751, DOI 10.1017/S0033291722001696
   O'Donnell P, 2023, NEUROPSYCHOPHARMACOL, V48, P1052, DOI 10.1038/s41386-023-01560-0
   O'Reilly K, 2016, PSYCHOL MED, V46, P3199, DOI 10.1017/S0033291716002154
   Ohi K, 2022, J CLIN PSYCHOPHARM, V42, P227, DOI 10.1097/JCP.0000000000001232
   Olivola M, 2023, CURR NEUROPHARMACOL, V21, P2431, DOI 10.2174/1570159X21666230727140843
   Palumbo D, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.622359
   Parikh NB, 2017, THER CLIN RISK MANAG, V13, P299, DOI 10.2147/TCRM.S94060
   Penadés R, 2020, SCHIZOPHR RES-COGN, V19, DOI 10.1016/j.scog.2019.100146
   Picton JD, 2018, AM J HEALTH-SYST PH, V75, pE6, DOI 10.2146/ajhp160381
   Pillinger T, 2020, LANCET PSYCHIAT, V7, P64, DOI 10.1016/S2215-0366(19)30416-X
   Pinkham AE, 2018, SCHIZOPHRENIA BULL, V44, P737, DOI 10.1093/schbul/sbx117
   Pinkham AE, 2016, SCHIZOPHRENIA BULL, V42, P494, DOI 10.1093/schbul/sbv056
   Pinkham AE, 2014, SCHIZOPHRENIA BULL, V40, P813, DOI 10.1093/schbul/sbt081
   Porter VR, 2015, CURR PSYCHIAT REP, V17, DOI 10.1007/s11920-015-0631-8
   Postolache TT, 2019, AM J MED GENET B, V180, P186, DOI 10.1002/ajmg.b.32712
   Potvin S, 2014, J ADDICT MED, V8, P368, DOI 10.1097/ADM.0000000000000066
   Ranganathan M, 2006, PSYCHOPHARMACOLOGY, V188, P425, DOI 10.1007/s00213-006-0508-y
   Reichenberg Abraham, 2010, Dialogues Clin Neurosci, V12, P383
   Reinharth J., 2014, SCHIZOPHR RES-COGN, V1, P101, DOI DOI 10.1016/J.SCOG.2014.06.001
   Rocca P, 2023, EUR PSYCHIAT, V66, DOI 10.1192/j.eurpsy.2022.2356
   Rosenbrock H, 2023, EUR ARCH PSY CLIN N, V273, P1557, DOI 10.1007/s00406-023-01576-z
   Rund BR, 2016, SCHIZOPHRENIA BULL, V42, P87, DOI 10.1093/schbul/sbv083
   Sadeghi D, 2022, COMPUT BIOL MED, V146, DOI 10.1016/j.compbiomed.2022.105554
   Sauder C, 2022, TRANSL PSYCHIAT, V12, DOI 10.1038/s41398-022-02254-9
   Savla GN, 2013, SCHIZOPHRENIA BULL, V39, P979, DOI 10.1093/schbul/sbs080
   Schmitt A, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00690
   Schneider-Thoma J, 2022, LANCET, V399, P824, DOI 10.1016/S0140-6736(21)01997-8
   Schuster JP, 2020, INT PSYCHOGERIATR, V32, P441, DOI 10.1017/S1041610219000358
   Semisa D., 2022, Raccomandazioni di buone pratiche in riabilitazione psicosociale per adulti
   Shimada T, 2022, PSYCHIAT RES, V314, DOI 10.1016/j.psychres.2022.114656
   Shou YK, 2020, FRONT CELL DEV BIOL, V8, DOI 10.3389/fcell.2020.579659
   Siervo M, 2014, J ALZHEIMERS DIS, V41, P151, DOI 10.3233/JAD-132279
   Singh Alok, 2022, Innov Clin Neurosci, V19, P43
   Skvarc DR, 2017, NEUROSCI BIOBEHAV R, V78, P44, DOI 10.1016/j.neubiorev.2017.04.013
   Sloan NP, 2021, NEUROPSYCHOL REV, V31, P115, DOI 10.1007/s11065-020-09454-4
   Spangaro M, 2018, SCHIZOPHR RES, V202, P106, DOI 10.1016/j.schres.2018.06.059
   Spronk DB, 2013, NEUROSCI BIOBEHAV R, V37, P1838, DOI 10.1016/j.neubiorev.2013.07.003
   Stewart SA, 2005, J CLIN PSYCHIAT, V66, P9
   Stout JW, 2021, J HEALTH PSYCHOL, V26, P2248, DOI 10.1177/1359105320909861
   Tabatabaee M, 2021, BJPSYCH INT, V18, DOI 10.1192/bji.2021.18
   Tahmi M, 2021, CURR CARDIOL REP, V23, DOI 10.1007/s11886-021-01615-y
   Thompson WK, 2013, SCHIZOPHR RES, V143, P90, DOI 10.1016/j.schres.2012.10.033
   Vancampfort D, 2013, WORLD PSYCHIATRY, V12, P240, DOI 10.1002/wps.20069
   Ventriglio A, 2021, CURR TOP MED CHEM, V21, P1500, DOI 10.2174/1568026621666210701103147
   Ventura J, 2010, SCHIZOPHR RES, V121, P24, DOI 10.1016/j.schres.2010.04.016
   Veselinovic T, 2022, CNS DRUGS, V36, P819, DOI 10.1007/s40263-022-00935-z
   Viganò C, 2023, FRONT PSYCHIATRY, V14, DOI 10.3389/fpsyt.2023.1130811
   Vinogradov S, 2009, AM J PSYCHIAT, V166, P1055, DOI 10.1176/appi.ajp.2009.09010017
   Vita A, 2023, PSYCHOL MED, V53, P7943, DOI 10.1017/S0033291723002106
   Vita A, 2024, INT J SOC PSYCHIATR, V70, P408, DOI 10.1177/00207640231181526
   Vita A, 2022, EUR PSYCHIAT, V65, DOI 10.1192/j.eurpsy.2022.2315
   Vita A, 2022, EUR PSYCHIAT, V65, DOI 10.1192/j.eurpsy.2022.2316
   Vita A, 2023, PSYCHOL MED, V53, P3661, DOI 10.1017/S0033291722000319
   Vita A, 2021, JAMA PSYCHIAT, V78, P848, DOI 10.1001/jamapsychiatry.2021.0620
   Vita A, 2020, EUR PSYCHIAT, V63, DOI 10.1192/j.eurpsy.2020.99
   Vita A, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00147
   Vita A, 2018, CURR OPIN PSYCHIATR, V31, P246, DOI 10.1097/YCO.0000000000000407
   Whiting D, 2022, JAMA PSYCHIAT, V79, P120, DOI 10.1001/jamapsychiatry.2021.3721
   Wilson L, 2018, SCHIZOPHR RES, V197, P78, DOI 10.1016/j.schres.2017.11.001
   Winklbaur Bernadette, 2006, Dialogues Clin Neurosci, V8, P37
   Wykes T, 2018, J PSYCHOPATHOL, V24, P57
   WYKES T, 1992, PSYCHOL MED, V22, P389, DOI 10.1017/S0033291700030336
   Wykes T, 2011, AM J PSYCHIAT, V168, P472, DOI 10.1176/appi.ajp.2010.10060855
   Yaffe K, 2007, ALZ DIS ASSOC DIS, V21, P167, DOI 10.1097/WAD.0b013e318065bfd6
   Yaffe K, 2014, LANCET NEUROL, V13, P1017, DOI 10.1016/S1474-4422(14)70172-3
   Yates KF, 2012, ARTERIOSCL THROM VAS, V32, P2060, DOI 10.1161/ATVBAHA.112.252759
   Yeo H, 2022, BRIT J CLIN PSYCHOL, V61, P37, DOI 10.1111/bjc.12320
   Yolland COB, 2020, AUST NZ J PSYCHIAT, V54, P453, DOI 10.1177/0004867419893439
   Yu LF, 2020, SCHIZOPHR RES, V224, P2, DOI 10.1016/j.schres.2020.10.006
   Yücel M, 2012, SCHIZOPHRENIA BULL, V38, P316, DOI 10.1093/schbul/sbq079
   Zanelli J, 2019, AM J PSYCHIAT, V176, P811, DOI 10.1176/appi.ajp.2019.18091088
   Zhuo CJ, 2017, FRONT MOL NEUROSCI, V10, DOI 10.3389/fnmol.2017.00028
NR 234
TC 3
Z9 3
U1 3
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD SEP 20
PY 2024
VL 15
AR 1451832
DI 10.3389/fpsyt.2024.1451832
PG 14
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA H8L2Z
UT WOS:001325894100001
PM 39371908
OA gold
DA 2025-06-11
ER

PT J
AU Black, DR
   Held, ML
AF Black, Denise R.
   Held, Mary L.
TI Cardiovascular risk screening for individuals with serious mental
   illness
SO SOCIAL WORK IN HEALTH CARE
LA English
DT Article
DE Cardiovascular disease; screening; serious mental illness
ID METABOLIC SYNDROME; MEDICAL-CARE; HEALTH-CARE; SCHIZOPHRENIA; PEOPLE;
   DISORDERS; SMOKING; OBESITY; ACCESS; ADULTS
AB Cardiovascular disease (CVD) is a significant health risk for individuals with serious mental illness (SMI). Screening for CVD risk factors is a key strategy to reduce this health disparity. This study examined medical, lifestyle, and access predictors for comprehensive screening. Data on 1036 adults were analyzed from the 2015 National Health Interview Survey. Multivariate multinomial logistic regression was used to examine factors associated with individuals with SMI receiving CVD risk screening in the past 12months. The presence of a metabolic disorder (diabetes or high cholesterol), increased age, increased outpatient visits, and seeing a primary care provider, either alone or in conjunction with a specialty care provider, were significantly associated with receiving all screening measures. Increasing provider awareness of additional CVD risk factors is an essential step to improving early detection of health risks for individuals with SMI. Integrated health settings that combine traditional primary care and mental health services may reduce the health disparity for this population by increasing odds of early detection and ongoing monitoring for high-risk populations.
C1 [Black, Denise R.] Univ Tennessee, Coll Social Work, 1618 Cumberland Ave, Knoxville, TN 37996 USA.
   [Held, Mary L.] Univ Tennessee, Coll Social Work, Nashville, TN USA.
C3 University of Tennessee System; University of Tennessee Knoxville;
   University of Tennessee System; University of Tennessee Knoxville
RP Black, DR (corresponding author), Univ Tennessee, Coll Social Work, 1618 Cumberland Ave, Knoxville, TN 37996 USA.
EM dblack16@vols.utk.edu
CR Amer Diabet Assoc, 2004, DIABETES CARE, V27, P596, DOI 10.2337/diacare.27.2.596
   ANDERSEN RM, 1995, J HEALTH SOC BEHAV, V36, P1, DOI 10.2307/2137284
   Baptista T, 2004, METAB SYNDR RELAT D, V2, P290, DOI 10.1089/met.2004.2.290
   Barnett AH, 2007, J PSYCHOPHARMACOL, V21, P357, DOI 10.1177/0269881107075509
   Bermudes RA, 2006, PSYCHOSOMATICS, V47, P491, DOI 10.1176/appi.psy.47.6.491
   Brunero S, 2009, INT J MENT HEALTH NU, V18, P144, DOI 10.1111/j.1447-0349.2009.00595.x
   Cannon Christopher P, 2007, Clin Cornerstone, V8, P11, DOI 10.1016/S1098-3597(07)80025-1
   Casey Daniel E, 2005, Am J Med, V118 Suppl 2, p15S
   Citrome Leslie, 2005, J Psychopharmacol, V19, P102, DOI 10.1177/0269881105059505
   Compton MT, 2006, HARVARD REV PSYCHIAT, V14, P212, DOI 10.1080/10673220600889256
   Daumit GL, 2005, J NERV MENT DIS, V193, P641, DOI 10.1097/01.nmd.0000180737.85895.60
   De Hert M, 2010, EUR PSYCHIAT, V25, pS22, DOI 10.1016/S0924-9338(10)71702-8
   De Hert M, 2009, WORLD PSYCHIATRY, V8, P15
   Druss BG, 2001, ARCH GEN PSYCHIAT, V58, P861, DOI 10.1001/archpsyc.58.9.861
   Druss BG, 1998, AM J PSYCHIAT, V155, P1775, DOI 10.1176/ajp.155.12.1775
   Frayne SM, 2005, ARCH INTERN MED, V165, P2631, DOI 10.1001/archinte.165.22.2631
   Gerrity M., 2014, INTEGRATING PRIMARY
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Heath B., 2013, A Review and Proposed Standard Framework for Levels of Integrated Healthcare
   Hennekens CH, 2005, AM HEART J, V150, P1115, DOI 10.1016/j.ahj.2005.02.007
   Kaufman Erin Anne, 2012, Issues Ment Health Nurs, V33, P172, DOI 10.3109/01612840.2011.638415
   Kaur J., 2014, Medical Sciences, V2, P140, DOI DOI 10.3390/MEDSCI2030140
   Kessler RC, 2003, ARCH GEN PSYCHIAT, V60, P184, DOI 10.1001/archpsyc.60.2.184
   Kessler RC, 2002, PSYCHOL MED, V32, P959, DOI 10.1017/S0033291702006074
   Kilbourne AM, 2009, GEN HOSP PSYCHIAT, V31, P555, DOI 10.1016/j.genhosppsych.2009.07.008
   Lawrence D, 2010, J PSYCHOPHARMACOL, V24, P61, DOI 10.1177/1359786810382058
   Levinson MillerC., 2003, PSYCHIATRICSERVICES, V54, P1158, DOI DOI 10.1176/APPI.PS.54.8.1158
   Mangurian C, 2013, PSYCHIAT SERV, V64, P597, DOI 10.1176/appi.ps.002542012
   Marder SR, 2004, AM J PSYCHIAT, V161, P1334, DOI 10.1176/appi.ajp.161.8.1334
   McClave AK, 2010, AM J PUBLIC HEALTH, V100, P2464, DOI 10.2105/AJPH.2009.188136
   McCreadie RG, 2003, BRIT J PSYCHIAT, V183, P534, DOI 10.1192/bjp.183.6.534
   Mitchell AJ, 2013, PSYCHIAT SERV, V64, P1060, DOI 10.1176/appi.ps.201200514
   Morden NE, 2009, J AM BOARD FAM MED, V22, P187, DOI 10.3122/jabfm.2009.02.080059
   Morrato EH, 2010, ARCH GEN PSYCHIAT, V67, P17, DOI 10.1001/archgenpsychiatry.2009.179
   Parameswaran SG, 2013, SCHIZOPHR RES, V143, P395, DOI 10.1016/j.schres.2012.08.031
   Parks J., 2006, Morbidity and mortality in people with serious mental illness
   Peek CJ, 2013, LEXICON BEHAV HLTH P, V13 IP001 EF
   REGIER DA, 1990, JAMA-J AM MED ASSOC, V264, P2511
   Scharf D M., 2014, Evaluation of the SAMHSA Primary and Behavioral Health Care Integration (PBHCI) grant program: Final report (Task 13)
   Shore JH, 1996, AM J PSYCHIAT, V153, P1398
   Susce MT, 2005, J CLIN PSYCHIAT, V66, P167, DOI 10.4088/JCP.v66n0203
   Swartz JA, 2006, J SUBST ABUSE TREAT, V31, P287, DOI 10.1016/j.jsat.2006.04.009
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
NR 43
TC 4
Z9 4
U1 1
U2 4
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0098-1389
EI 1541-034X
J9 SOC WORK HEALTH CARE
JI Soc. Work Health Care
PY 2017
VL 56
IS 9
BP 809
EP 821
DI 10.1080/00981389.2017.1354955
PG 13
WC Social Work
WE Social Science Citation Index (SSCI)
SC Social Work
GA FE0ZA
UT WOS:000407947000003
PM 28771089
DA 2025-06-11
ER

PT J
AU Bobrowski, AE
AF Bobrowski, Amy E.
TI School and sports participation post-transplant
SO PEDIATRIC TRANSPLANTATION
LA English
DT Article
DE cognitive effects; physical activity; psychosocial effects; school
ID QUALITY-OF-LIFE; SOLID-ORGAN TRANSPLANTATION; PEDIATRIC HEART; METABOLIC
   SYNDROME; CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY;
   KIDNEY-TRANSPLANTATION; SCIENTIFIC STATEMENT; YOUNG-ADULTS; CHILDREN
AB Pediatric recipients of life-saving organ transplants are living longer, with improved graft and overall survivals. After successful transplant, children are encouraged to return to "normal life," with school attendance and participation in age-appropriate physical activities. This transition may cause stress to the recipients, parents, teachers, and other participating caregivers and staff. Planning for school reentry and assuring education for and open lines of communication with the school staff can help alleviate some of this discomfort and ease the process for the patient and the family. Cardiovascular disease has emerged as the leading cause of death in survivors of pediatric transplantation and is contributed to by modifiable risk factors such as obesity, hypertension, and the MS. Physical activity is a proven tool in decreasing surrogate markers of this risk. Sports participation is an important way to promote an enjoyment of physical activity that can ideally persist into adulthood, but conflicting advice and opinions exist regarding type and participation in physical activity. Moreover, specific recommendations are likely not applicable to all recipients, as certain degrees of rehabilitation may be needed depending on degree and length of illness. In general, a program of rehabilitation and increased physical activity has been shown to be safe and effective for most pediatric transplant recipients. Focusing on optimizing the "normal" childhood activities of going to school and participating in sports can improve the physical, social, cognitive, and mental health outcomes of this population after transplant and should be prioritized.
C1 [Bobrowski, Amy E.] Northwestern Univ, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med, Div Pediat Kidney Dis, Chicago, IL 60611 USA.
C3 Ann & Robert H. Lurie Children's Hospital of Chicago; Northwestern
   University; Feinberg School of Medicine
RP Bobrowski, AE (corresponding author), Northwestern Univ, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med, Div Pediat Kidney Dis, Chicago, IL 60611 USA.
EM abobrowski@luriechildrens.org
OI Bobrowski, Amy/0000-0002-1924-0659
CR Alonso EM, 2009, CURR OPIN ORGAN TRAN, V14, P522, DOI 10.1097/MOT.0b013e3283307a62
   Annunziato RA, 2012, PEDIATR TRANSPLANT, V16, P803, DOI 10.1111/j.1399-3046.2012.01749.x
   Anthony SJ, 2010, PEDIATR CLIN N AM, V57, P559, DOI 10.1016/j.pcl.2010.01.006
   Armstrong KA, 2005, AM J TRANSPLANT, V5, P2710, DOI 10.1111/j.1600-6143.2005.01073.x
   Avery RK, 2019, CLIN TRANSPLANT, V33, DOI 10.1111/ctr.13519
   Bartosh S, PEDIAT KIDNEY TRANSP
   Becker-Cohen R, 2006, CLIN J AM SOC NEPHRO, V1, P1284, DOI 10.2215/CJN.01480506
   Blöte R, 2019, TRANSPLANTATION, V103, P2423, DOI 10.1097/TP.0000000000002675
   Brosig Cheryl, 2006, Prog Transplant, V16, P38
   Brosig C, 2014, PEDIATR TRANSPLANT, V18, P559, DOI 10.1111/petr.12286
   Brouhard B H, 2000, Pediatr Transplant, V4, P261, DOI 10.1034/j.1399-3046.2000.00121.x
   Bürker BS, 2017, CLIN TRANSPLANT, V31, DOI 10.1111/ctr.12927
   Burroughs TE, 2009, TRANSPLANTATION, V88, P367, DOI 10.1097/TP.0b013e3181ae67f0
   Cho Min Hyun, 2018, Korean J Pediatr, V61, P205, DOI 10.3345/kjp.2018.61.7.205
   Cicognani E, 2015, PSYCHOL HEALTH MED, V20, P997, DOI 10.1080/13548506.2014.993404
   Cole CR, 2004, PEDIATR TRANSPLANT, V8, P222, DOI 10.1111/j.1399-3046.2004.00126.x
   Danzinger-Isakov L, 2009, AM J TRANSPLANT, V9, pS258, DOI 10.1111/j.1600-6143.2009.02917.x
   de Vries APJ, 2004, AM J TRANSPLANT, V4, P1675, DOI 10.1111/j.1600-6143.2004.00558.x
   Deliva RD, 2012, PEDIATR TRANSPLANT, V16, P879, DOI 10.1111/petr.12003
   Dipchand AI, 2018, ANN CARDIOTHORAC SUR, V7, P31, DOI 10.21037/acs.2018.01.07
   Diseth TH, 2011, PEDIATR NEPHROL, V26, P1881, DOI 10.1007/s00467-011-1887-9
   Dunkley AJ, 2012, DIABETES OBES METAB, V14, P616, DOI 10.1111/j.1463-1326.2012.01571.x
   Fioretto P, 2011, CLIN J AM SOC NEPHRO, V6, P101, DOI 10.2215/CJN.03850510
   Forrest CB, 2011, PEDIATRICS, V128, P303, DOI 10.1542/peds.2010-3347
   Fredericks EM, 2007, AM J TRANSPLANT, V7, P1974, DOI 10.1111/j.1600-6143.2007.01878.x
   Gilmour SM, 2010, LIVER TRANSPLANT, V16, P1041, DOI 10.1002/lt.22120
   Gipson DS, 2006, CHILD NEUROPSYCHOL, V12, P391, DOI 10.1080/09297040600876311
   Grinsell MM, 2006, PEDIATRICS, V118, P1019, DOI 10.1542/peds.2006-0663
   Hricik DE, 2011, CLIN J AM SOC NEPHRO, V6, P1781, DOI 10.2215/CJN.01200211
   Icard P, 2010, PEDIATR TRANSPLANT, V14, P887, DOI 10.1111/j.1399-3046.2010.01359.x
   Johnson B, 2005, J UROLOGY, V174, P686, DOI 10.1097/01.ju.0000164719.91332.42
   Kaller T, 2005, TRANSPLANTATION, V79, P1252, DOI 10.1097/01.TP.0000161251.20520.42
   Kavey REW, 2006, CIRCULATION, V114, P2710, DOI 10.1161/CIRCULATIONAHA.106.179568
   Koulouridis E, 2010, PEDIATR NEPHROL, V25, P491, DOI 10.1007/s00467-009-1364-x
   Krasnoff JB, 2006, TRANSPLANTATION, V82, P211, DOI 10.1097/01.tp.0000226160.40527.5f
   Lau KK, 2012, TRANSL PEDIATR, V1, P35, DOI 10.3978/j.issn.2224-4336.2012.02.02
   Lerret SM, 2014, PEDIATR TRANSPLANT, V18, P527, DOI 10.1111/petr.12269
   Limbers CA, 2011, PEDIATR TRANSPLANT, V15, P245, DOI 10.1111/j.1399-3046.2010.01453.x
   Litwin M, 2010, PEDIATR NEPHROL, V25, P2489, DOI 10.1007/s00467-010-1626-7
   Lubrano R, 2012, NEPHROL DIAL TRANSPL, V27, P1677, DOI 10.1093/ndt/gfr434
   Madan-Swain A, 2004, HANDBOOK OF PEDIATRIC PSYCHOLOGY IN SCHOOL SETTINGS, P637
   Marino BS, 2012, CIRCULATION, V126, P1143, DOI 10.1161/CIR.0b013e318265ee8a
   Mazzoni D, 2014, TRANSPL P, V46, P2231, DOI 10.1016/j.transproceed.2014.07.049
   McDonald SP, 2004, NEW ENGL J MED, V350, P2654, DOI 10.1056/NEJMoa031643
   Mukherjee S, 2000, EDUC RES-UK, V42, P59, DOI 10.1080/001318800363917
   Parekh RS, 2002, J PEDIATR-US, V141, P191, DOI 10.1067/mpd.2002.125910
   Pastore E, 2001, PEDIATR TRANSPLANT, V5, P425, DOI 10.1034/j.1399-3046.2001.t01-2-00032.x
   Patel JN, 2008, PEDIATR TRANSPLANT, V12, P336, DOI 10.1111/j.1399-3046.2007.00806.x
   Porrini E, 2006, AM J KIDNEY DIS, V48, P134, DOI 10.1053/j.ajkd.2006.04.078
   Poursanidou K, 2003, SUPPORT LEARN, V18, P170
   Raj VMS, 2017, TRANSL PEDIATR, V6, P207, DOI 10.21037/tp.2017.06.03
   Samsel C, 2019, PEDIATR TRANSPLANT, V23, DOI 10.1111/petr.13380
   SEXSON SB, 1993, J LEARN DISABIL, V26, P115, DOI 10.1177/002221949302600204
   Shemesh E, 2010, LIVER TRANSPLANT, V16, P1013, DOI 10.1002/lt.22134
   Slapak M., 2005, ANN TRANSPL, V10, P62
   Thies KM, 1999, J SCHOOL HEALTH, V69, P392, DOI 10.1111/j.1746-1561.1999.tb06354.x
   Todaro JF, 2000, J PEDIATR PSYCHOL, V25, P567, DOI 10.1093/jpepsy/25.8.567
   United States Renal Data System, 2017, US REN DAT SYST USRD
   Weigmann-Fassender S, 2020, PEDIATR TRANSPLANT, V24, DOI 10.1111/petr.13630
   Weil CM, 2006, PEDIATR TRANSPLANT, V10, P928, DOI 10.1111/j.1399-3046.2006.00586.x
   Wilson AC, 2010, PEDIATR TRANSPLANT, V14, P52, DOI 10.1111/j.1399-3046.2009.01141.x
   Wolf MF, 2016, J PEDIATR-US, V179, P90, DOI 10.1016/j.jpeds.2016.08.079
   Woo KS, 2004, CIRCULATION, V109, P1981, DOI 10.1161/01.CIR.0000126599.47470.BE
   Wray J, 2005, PEDIATR TRANSPLANT, V9, P170, DOI 10.1111/j.1399-3046.2005.00265.x
   Yazigi NA, 2013, PEDIATR GASTROENTERO, V16, P207, DOI 10.5223/pghn.2013.16.4.207
NR 65
TC 5
Z9 5
U1 1
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1397-3142
EI 1399-3046
J9 PEDIATR TRANSPLANT
JI Pediatr. Transplant.
PD FEB
PY 2021
VL 25
IS 1
AR e13791
DI 10.1111/petr.13791
EA JUL 2020
PG 8
WC Pediatrics; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics; Transplantation
GA YY1FO
UT WOS:000552878200001
PM 33202076
DA 2025-06-11
ER

PT J
AU Ferraz-Bannitz, R
   Beraldo, RA
   Coelho, PO
   Moreira, AC
   Castro, M
   Foss-Freitas, MC
AF Ferraz-Bannitz, Rafael
   Beraldo, Rebeca A.
   Coelho, Priscila Oliveira
   Moreira, Ayrton C.
   Castro, Margaret
   Foss-Freitas, Maria Cristina
TI Circadian Misalignment Induced by Chronic Night Shift Work Promotes
   Endoplasmic Reticulum Stress Activation Impacting Directly on Human
   Metabolism
SO BIOLOGY-BASEL
LA English
DT Article
DE endoplasmic reticulum stress; CLOCK genes; night shift; circadian
   rhythm; metabolic syndrome
AB Simple Summary
   The demands of modern society have made shift work a necessity. Night work is associated with an increased risk of metabolic problems such as obesity and diabetes, which is mainly due to the misalignment of circadian rhythms that play a crucial role in many biological processes. This study performed clinical, anthropometric, and molecular analyses on 40 hospital workers who work day or night. We demonstrated that night workers had increased glucose levels, triglycerides, waist circumference, and blood pressure compared to day workers. Surprisingly, we report that night workers have significant changes in the expression of circadian clock genes and an up-regulation of genes related to endoplasmic reticulum stress (ERS). These findings provide new insights into the effects of night shift work on the expression of circadian cycle genes and ERS activation, leading to metabolic stress and the development of metabolic diseases associated with night work.
   Night work has become necessary in our modern society. However, sleep deprivation induces a circadian misalignment that effectively contributes to the development of diseases associated with metabolic syndrome, such as obesity and diabetes. Here, we evaluated the pattern of circadian clock genes and endoplasmic reticulum stress (ERS) genes in addition to metabolic and anthropometric measures in subjects that work during a nocturnal period compared with day workers. We study 20 night workers (NW) and 20 day workers (DW) submitted to a work schedule of 12 h of work for 36 h of rest for at least 5 years in a hospital. The present report shows that NW have increased fasting blood glucose, glycated hemoglobin (HbA1c), triglycerides, and low-density lipoprotein (LDL)-cholesterol levels, and lower high-density lipoprotein (HDL)-cholesterol levels compared to DW. In addition, we observed that waist circumference (WC), waist-hip ratio (WHR), and systemic blood pressure are also increased in NW. Interestingly, gene expression analysis showed changes in CLOCK gene expression in peripheral blood mononuclear cells (PBMC) samples of NW compared to the DW, evidencing a peripheral circadian misalignment. This metabolic adaptation was accompanied by the up-regulation of many genes of ERS in NW. These findings support the hypothesis that night shift work results in disturbed glycemic and lipid control and affects the circadian cycle through the deregulation of peripheral CLOCK genes, which is possibly due to the activation of ERS. Thus, night work induces important metabolic changes that increase the risk of developing metabolic syndrome.
C1 [Ferraz-Bannitz, Rafael; Beraldo, Rebeca A.; Moreira, Ayrton C.; Castro, Margaret; Foss-Freitas, Maria Cristina] Ribeirao Preto Med Sch, Dept Internal Med, Div Endocrinol & Metab, Ave Bandeirantes,3900 Vila Monte Alegre, BR-14049900 Ribeirao Preto, SP, Brazil.
   [Coelho, Priscila Oliveira] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Biochem, Ave Bandeirantes,3900 Vila Monte Alegre, BR-14049900 Ribeirao Preto, SP, Brazil.
C3 Universidade de Sao Paulo
RP Ferraz-Bannitz, R (corresponding author), Ribeirao Preto Med Sch, Dept Internal Med, Div Endocrinol & Metab, Ave Bandeirantes,3900 Vila Monte Alegre, BR-14049900 Ribeirao Preto, SP, Brazil.
EM ferrazrafael@usp.br; rebecaberaldo@yahoo.com.br;
   priscila_coelho6@hotmail.com; acmoreir@fmrp.usp.br; castrom@fmrp.usp.br;
   crisfoss@fmrp.usp.br
RI Foss-Freitas, Maria/AAV-5971-2021; Ferraz-Bannitz, Rafael/AAI-2715-2021;
   Beraldo, Rebeca/J-7380-2016; Coelho, Priscila/JCE-1771-2023;
   Foss-Freitas, Maria Cristina/F-1197-2013; de Castro,
   Margaret/A-4918-2009; Ferraz-Bannitz, Rafael/C-2390-2018
OI Foss-Freitas, Maria Cristina/0000-0002-1350-1125; de Castro,
   Margaret/0000-0003-4932-4623; Ferraz-Bannitz, Rafael/0000-0003-4496-4883
FU Fundacao de Apoio ao Ensino Pesquisa e Assistencia (FAEPA); Fundacao de
   Amparo a Pesquisa do Estado de Sao Paulo-FAPESP [2015/12133-0]
FX This work was supported by Fundacao de Apoio ao Ensino Pesquisa e
   Assistencia (FAEPA) and the Fundacao de Amparo a Pesquisa do Estado de
   Sao Paulo-FAPESP (2015/12133-0).
CR Ajabnoor GMA, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0174342
   Al-Naimi S, 2004, CHRONOBIOL INT, V21, P937, DOI 10.1081/CBI-200037171
   Ayas NT, 2003, DIABETES CARE, V26, P380, DOI 10.2337/diacare.26.2.380
   Bahijri S, 2013, PLOS ONE, V8, DOI [10.1371/journal.pone.0060917, 10.1371/annotation/8d92315c-9944-4470-9bbb-806a26b0809b]
   Brum MCB, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/s13098-015-0041-4
   Cappuccio FP, 2008, SLEEP, V31, P619, DOI 10.1093/sleep/31.5.619
   Cappuccio FP, 2011, EUR HEART J, V32, P1484, DOI 10.1093/eurheartj/ehr007
   Cappuccio FP, 2010, SLEEP, V33, P585, DOI 10.1093/sleep/33.5.585
   Costa G, 2004, REV SAUDE PUBL, V38, P86, DOI 10.1590/S0034-89102004000700013
   Darlington TK, 1998, SCIENCE, V280, P1599, DOI 10.1126/science.280.5369.1599
   Dashti HS, 2015, AM J CLIN NUTR, V101, P135, DOI 10.3945/ajcn.114.095026
   Dijk DJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030037
   Foss-Freitas MC, 2018, DIABETOL METAB SYNDR, V10, DOI 10.1186/s13098-017-0301-6
   Gangwisch JE, 2005, SLEEP, V28, P1289, DOI 10.1093/sleep/28.10.1289
   Gao L, 2019, CELL SIGNAL, V57, P89, DOI 10.1016/j.cellsig.2019.01.008
   Garaulet M, 2010, INT J OBESITY, V34, P1667, DOI 10.1038/ijo.2010.118
   Gekakis N, 1998, SCIENCE, V280, P1564, DOI 10.1126/science.280.5369.1564
   Ghemrawi R, 2018, CELLS-BASEL, V7, DOI 10.3390/cells7060063
   Ghiasvand M, 2006, LIPIDS HEALTH DIS, V5, DOI 10.1186/1476-511X-5-9
   Griffin EA, 1999, SCIENCE, V286, P768, DOI 10.1126/science.286.5440.768
   Hakim F, 2015, SLEEP, V38, P31, DOI 10.5665/sleep.4320
   Hannerz H, 2004, HEALTH PSYCHOL, V23, P283, DOI 10.1037/0278-6133.23.3.283
   Harding HP, 2002, ANNU REV CELL DEV BI, V18, P575, DOI 10.1146/annurev.cellbio.18.011402.160624
   Honma S, 2002, NATURE, V419, P841, DOI 10.1038/nature01123
   Kalsbeek A, 2014, MOL METAB, V3, P372, DOI 10.1016/j.molmet.2014.03.002
   Kim S, 2017, CHRONOBIOL INT, V34, P1057, DOI 10.1080/07420528.2017.1337780
   Knutsson A, 2003, OCCUP MED-OXFORD, V53, P103, DOI 10.1093/occmed/kqg048
   Korompeli A, 2009, J ADV NURS, V65, P1274, DOI 10.1111/j.1365-2648.2009.04987.x
   Koyanagi S, 2011, J BIOL CHEM, V286, P32416, DOI 10.1074/jbc.M111.258970
   Kroenke CH, 2007, AM J EPIDEMIOL, V165, P175, DOI 10.1093/aje/kwj355
   Lowrey PL, 2000, ANNU REV GENET, V34, P533, DOI 10.1146/annurev.genet.34.1.533
   Marcheva B, 2010, NATURE, V466, P627, DOI 10.1038/nature09253
   McHill AW, 2014, P NATL ACAD SCI USA, V111, P17302, DOI 10.1073/pnas.1412021111
   Moreira AC, 2018, EUR J ENDOCRINOL, V179, pR1, DOI 10.1530/EJE-18-0102
   Morikawa Y, 2005, SCAND J WORK ENV HEA, V31, P179, DOI 10.5271/sjweh.867
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Pan A, 2011, PLOS MED, V8, DOI 10.1371/journal.pmed.1001141
   Panda S, 2002, CELL, V109, P307, DOI 10.1016/S0092-8674(02)00722-5
   Patel P, 2013, NUTRIENTS, V5, P2019, DOI 10.3390/nu5062019
   Perez-Tilve D, 2006, ENDOCRINOLOGY, V147, P1136, DOI 10.1210/en.2005-1586
   Reszka E, 2013, SCAND J WORK ENV HEA, V39, P178, DOI 10.5271/sjweh.3299
   Roa SLR, 2017, ENDOCRINOLOGY, V158, P1339, DOI 10.1210/en.2016-1782
   Rutter J, 2002, ANNU REV BIOCHEM, V71, P307, DOI 10.1146/annurev.biochem.71.090501.142857
   Schäfer M, 2015, FREE RADICAL BIO MED, V88, P243, DOI 10.1016/j.freeradbiomed.2015.04.018
   Scheer FAJL, 2009, P NATL ACAD SCI USA, V106, P4453, DOI 10.1073/pnas.0808180106
   Shearman LP, 2000, SCIENCE, V288, P1013, DOI 10.1126/science.288.5468.1013
   Shi YG, 2003, ENDOCR REV, V24, P91, DOI 10.1210/er.2002-0018
   Shi YG, 1998, MOL CELL BIOL, V18, P7499, DOI 10.1128/MCB.18.12.7499
   Skene DJ, 2018, P NATL ACAD SCI USA, V115, P7825, DOI 10.1073/pnas.1801183115
   Storch KF, 2002, NATURE, V417, P78, DOI 10.1038/nature744
   Stranges S, 2010, J HYPERTENS, V28, P896, DOI 10.1097/HJH.0b013e328335d076
   van Amelsvoort LGPM, 2004, J OCCUP ENVIRON MED, V46, P699, DOI 10.1097/01.jom.0000131794.83723.45
   Van Someren EJW, 2007, SLEEP MED REV, V11, P465, DOI 10.1016/j.smrv.2007.07.003
   Wible RS, 2018, ELIFE, V7, DOI 10.7554/eLife.31656
   Zhang HQ, 2015, FREE RADICAL BIO MED, V88, P314, DOI 10.1016/j.freeradbiomed.2015.05.036
NR 55
TC 13
Z9 16
U1 3
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2079-7737
J9 BIOLOGY-BASEL
JI Biology-Basel
PD MAR
PY 2021
VL 10
IS 3
AR 197
DI 10.3390/biology10030197
PG 13
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA RD3CT
UT WOS:000633361300001
PM 33807589
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ma, S
   Mifflin, SW
   Cunningham, JT
   Morilak, DA
AF Ma, S.
   Mifflin, S. W.
   Cunningham, J. T.
   Morilak, D. A.
TI Chronic intermittent hypoxia sensitizes acute
   hypothalamic-pituitary-adrenal stress reactivity and Fos induction in
   the rat locus coeruleus in response to subsequent immobilization stress
SO NEUROSCIENCE
LA English
DT Article
DE adrenocorticotropic hormone; metabolic syndrome; norepinephrine;
   obstructive sleep apnea; paraventricular nucleus; stress
ID OBSTRUCTIVE SLEEP-APNEA; EARLY GENE-EXPRESSION; PARAVENTRICULAR NUCLEUS;
   CELL RESPONSES; BRAIN-STEM; CORTICOSTERONE RESPONSES; NOREPINEPHRINE
   RELEASE; SUPRAOPTIC NUCLEI; MEDIAL AMYGDALA; BED NUCLEUS
AB Obstructive sleep apnea (OSA) is associated with several pathophysiological conditions, including hypertension, obesity, insulin resistance, hypothalamic-pituitary-adrenal (HPA) dysregulation, and other endocrine and metabolic disturbances comprising the "metabolic syndrome." Repeated episodes of hypoxia in OSA may represent a chronic intermittent stress, leading to HPA dysregulation. Alterations in HPA reactivity could then contribute to or exacerbate other pathophysiological processes. We showed previously that another metabolic stressor, chronic intermittent cold stress, enhanced noradrenergic facilitation of acute HPA stress reactivity. In this study, we investigated whether chronic intermittent hypoxia (CIH), a rat model for the arterial hypoxemia that accompanies OSA, similarly sensitizes the HPA response to novel acute stress. Rats were exposed to CIH (alternating cycles of normoxia [3 min at 21% O-2] and hypoxia [3 min at 10% O-2], repeated continuously for 8 h/day during the light portion of the cycle for 7 days). On the day after the final CIH exposure, there were no differences in baseline plasma adrenocorticotropic hormone (ACTH), but the peak ACTH response to 30 min acute immobilization stress was greater in CIH-stressed rats than in controls. Induction of Fos expression by acute immobilization stress was comparable following CIH in several HPA-modulatory brain regions, including the paraventricular nucleus, bed nucleus of the stria terminalis, and amygdala. Fos induction was attenuated in lateral hypothalamus, an HPA-inhibitory region. By contrast, acute Fos induction was enhanced in noradrenergic neurons in the locus coeruleus following CIH exposure. Thus, similar to chronic cold stress, CIH sensitized acute HPA and noradrenergic stress reactivity. Plasticity in the acute stress response is important for long-term adaptation, but may also contribute to pathophysiological conditions associated with states of chronic or repeated stress, such as OSA. Determining the neural mechanisms underlying these adaptations may help us better understand the etiology of such disorders, and inform the development of more effective treatments. (C) 2008 IBRO. Published by Elsevier Ltd. All rights reserved.
C1 Univ Texas Hlth Sci Ctr San Antonio, Dept Pharmacol, San Antonio, TX 78229 USA.
   Univ Texas Hlth Sci Ctr San Antonio, Ctr Biomed Neurosci, San Antonio, TX 78229 USA.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio; University of Texas System; University of Texas Health
   Science Center at San Antonio
RP Morilak, DA (corresponding author), Univ Texas Hlth Sci Ctr San Antonio, Dept Pharmacol, MC 7764,7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
EM morilak@uthscsa.edu
RI Morilak, David/Q-4986-2019
OI Cunningham, J. Thomas/0000-0001-8859-9481
FU NHLBI NIH HHS [R56 HL062579, HL062579, R01 HL062579, R01 HL086804,
   HL086804, P01 HL088052] Funding Source: Medline; NIMH NIH HHS [R01
   MH053851, MH053851, R01 MH072672, R29 MH053851, R56 MH053851, MH072672]
   Funding Source: Medline
CR ALDAMLUJI S, 1993, BAILLIERE CLIN ENDOC, V7, P355, DOI 10.1016/S0950-351X(05)80180-6
   Berridge CW, 2003, BRAIN RES REV, V42, P33, DOI 10.1016/S0165-0173(03)00143-7
   Bhatnagar S, 2000, J NEUROSCI, V20, P5564, DOI 10.1523/JNEUROSCI.20-14-05564.2000
   Bhatnagar S, 1998, NEUROSCIENCE, V84, P1025, DOI 10.1016/S0306-4522(97)00577-0
   Bratel T, 1999, RESP MED, V93, P1, DOI 10.1016/S0954-6111(99)90068-9
   Buckley TM, 2005, J CLIN ENDOCR METAB, V90, P3106, DOI 10.1210/jc.2004-1056
   CANTERAS NS, 1995, J COMP NEUROL, V360, P213, DOI 10.1002/cne.903600203
   Cecchi M, 2002, NEUROSCIENCE, V112, P13, DOI 10.1016/S0306-4522(02)00062-3
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   Cossette S, 2001, PSYCHOSOM MED, V63, P257, DOI 10.1097/00006842-200103000-00009
   Coughlin S, 2001, Obes Rev, V2, P267, DOI 10.1046/j.1467-789X.2001.00045.x
   Coughlin SR, 2004, EUR HEART J, V25, P735, DOI 10.1016/j.ehj.2004.02.021
   CULLINAN WE, 1995, NEUROBIOLOGICAL CLIN, P135
   CUNNINGHAM ET, 1990, J COMP NEUROL, V292, P651, DOI 10.1002/cne.902920413
   Curtis KS, 1999, AM J PHYSIOL-REG I, V277, pR532, DOI 10.1152/ajpregu.1999.277.2.R532
   DALLMAN MF, 1992, J NEUROENDOCRINOL, V4, P517, DOI 10.1111/j.1365-2826.1992.tb00200.x
   Dayas CV, 2002, EUR J NEUROSCI, V15, P1712, DOI 10.1046/j.1460-9568.2001.02011.x
   Dayas CV, 2001, NEUROSCIENCE, V105, P707, DOI 10.1016/S0306-4522(01)00213-5
   DUNN JD, 1987, BRAIN RES, V407, P327, DOI 10.1016/0006-8993(87)91111-5
   ELAM M, 1981, BRAIN RES, V222, P373, DOI 10.1016/0006-8993(81)91040-4
   FELDMAN S, 1994, BRAIN RES, V658, P21, DOI 10.1016/S0006-8993(09)90005-1
   FINLAY JM, 1995, NEUROSCIENCE, V64, P619, DOI 10.1016/0306-4522(94)00331-X
   GIBSON A, 1986, NEUROPHARMACOLOGY, V25, P257, DOI 10.1016/0028-3908(86)90248-0
   Gottlieb HB, 2006, AM J PHYSIOL-REG I, V290, pR1251, DOI 10.1152/ajpregu.00727.2005
   Greenberg HE, 1999, J APPL PHYSIOL, V86, P298, DOI 10.1152/jappl.1999.86.1.298
   HAUGER RL, 1990, BRAIN RES, V532, P34, DOI 10.1016/0006-8993(90)91738-3
   Herman JP, 2005, PROG NEURO-PSYCHOPH, V29, P1201, DOI 10.1016/j.pnpbp.2005.08.006
   Herman JP, 1997, TRENDS NEUROSCI, V20, P78, DOI 10.1016/S0166-2236(96)10069-2
   Herman JP, 2003, FRONT NEUROENDOCRIN, V24, P151, DOI 10.1016/j.yfrne.2003.07.001
   Hinojosa-Laborde C, 2005, HYPERTENSION, V46, P1016, DOI 10.1161/01.HYP.0000175477.33816.f3
   Hoffman GE., 1992, NEUROPROTOCOLS, V1, P52
   Iiyori N, 2007, AM J RESP CRIT CARE, V175, P851, DOI 10.1164/rccm.200610-1527OC
   JACOBSON L, 1989, J APPL PHYSIOL, V66, P2245, DOI 10.1152/jappl.1989.66.5.2245
   Jedema HP, 2001, BIOL PSYCHIAT, V49, P351, DOI 10.1016/S0006-3223(00)01057-X
   KISS A, 1992, NEUROENDOCRINOLOGY, V56, P153, DOI 10.1159/000126223
   Lanfranco F, 2004, CLIN ENDOCRINOL, V60, P41, DOI 10.1111/j.1365-2265.2004.01938.x
   Lesske J, 1997, J HYPERTENS, V15, P1593
   Li JG, 2005, CIRC RES, V97, P698, DOI 10.1161/01.RES.0000183879.60089.a9
   LIPOSITS Z, 1986, HISTOCHEMISTRY, V85, P95, DOI 10.1007/BF00491754
   Ma S, 2005, J NEUROENDOCRINOL, V17, P761, DOI 10.1111/j.1365-2826.2005.01372.x
   Ma S, 2005, J NEUROENDOCRINOL, V17, P22, DOI 10.1111/j.1365-2826.2005.01279.x
   Ma S, 2004, NEUROSCIENCE, V124, P963, DOI 10.1016/j.neuroscience.2003.12.028
   Mana MJ, 1997, NEUROSCIENCE, V81, P1055, DOI 10.1016/S0306-4522(97)00225-X
   McDonald TJ, 2000, BRAIN RES, V885, P70, DOI 10.1016/S0006-8993(00)02936-X
   McEwen BS, 2000, NEUROPSYCHOPHARMACOL, V22, P108, DOI 10.1016/S0893-133X(99)00129-3
   MELIA KR, 1994, J NEUROSCI, V14, P5929
   MORILAK DA, 1987, BRAIN RES, V422, P24, DOI 10.1016/0006-8993(87)90536-1
   Morilak DA, 2005, PROG NEURO-PSYCHOPH, V29, P1214, DOI 10.1016/j.pnpbp.2005.08.007
   MORILAK DA, 2005, SOC NEUR ABSTR, V31
   Mueller NK, 2004, ENDOCRINOLOGY, V145, P3763, DOI 10.1210/en.2004-0097
   NISENBAUM LK, 1991, J NEUROSCI, V11, P1478
   Ohayon MM, 2000, J PSYCHOSOM RES, V48, P593, DOI 10.1016/S0022-3999(00)00142-2
   PACAK K, 1992, BRAIN RES, V589, P91, DOI 10.1016/0006-8993(92)91165-B
   Pankow W, 2000, NEW ENGL J MED, V343, P966
   Pardon MC, 2003, BRAIN RES, V971, P55, DOI 10.1016/S0006-8993(03)02355-2
   Paxinos G, 1998, RAT BRAIN IN STEREOTAXIC COORDINATES, FOURTH ED., pix
   PLOTSKY PM, 1987, ENDOCRINOLOGY, V121, P924, DOI 10.1210/endo-121-3-924
   RAFF H, 1986, AM J PHYSIOL, V250, pR240, DOI 10.1152/ajpregu.1986.250.2.R240
   RAFF H, 1996, HDB PHYSL, P1259
   Randolph RR, 1998, AM J PHYSIOL-REG I, V274, pR1345, DOI 10.1152/ajpregu.1998.274.5.R1345
   SAWCHENKO PE, 1982, BRAIN RES REV, V4, P275, DOI 10.1016/0165-0173(82)90010-8
   Shamsuzzaman ASM, 2003, JAMA-J AM MED ASSOC, V290, P1906, DOI 10.1001/jama.290.14.1906
   Sica AL, 2000, BRAIN RES, V883, P224, DOI 10.1016/S0006-8993(00)02800-6
   Smith DW, 1995, J NEUROSCI, V15, P7979
   Smith R P, 1998, Sleep Med Rev, V2, P69, DOI 10.1016/S1087-0792(98)90001-6
   Stam R, 2000, EUR J PHARMACOL, V405, P217, DOI 10.1016/S0014-2999(00)00555-0
   SULLIVAN CE, 1985, CLIN CHEST MED, V6, P633
   SVENSSON TH, 1987, PSYCHOPHARMACOLOGY, V92, P1, DOI 10.1007/BF00215471
   SZAFARCZYK A, 1987, ENDOCRINOLOGY, V121, P883, DOI 10.1210/endo-121-3-883
   VALENTINO RJ, 1991, BRAIN RES, V555, P25, DOI 10.1016/0006-8993(91)90855-P
   Vgontzas AN, 2003, J INTERN MED, V254, P32, DOI 10.1046/j.1365-2796.2003.01177.x
   Walker BR, 2007, EUR J ENDOCRINOL, V157, P545, DOI 10.1530/EJE-07-0455
   Wang Minghan, 2005, Nutr Metab (Lond), V2, P3, DOI 10.1186/1743-7075-2-3
   Witchel SF, 2006, NAT CLIN PRACT ENDOC, V2, P621, DOI 10.1038/ncpendmet0323
   Woodward D J, 1991, Adv Exp Med Biol, V287, P193
NR 75
TC 69
Z9 84
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
EI 1873-7544
J9 NEUROSCIENCE
JI Neuroscience
PD JUL 17
PY 2008
VL 154
IS 4
BP 1639
EP 1647
DI 10.1016/j.neuroscience.2008.04.068
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 326RZ
UT WOS:000257677900047
PM 18554809
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Guo, QW
   Si, YJ
   Shen, YL
   Chen, X
   Yang, M
   Fang, DZ
   Lin, J
AF Guo, Qi Wei
   Si, Yan Jun
   Shen, Yi Lin
   Chen, Xu
   Yang, Mei
   Fang, Ding Zhi
   Lin, Jia
TI Depression Augments Plasma APOA4 without Changes of Plasma Lipids and
   Glucose in Female Adolescents Carrying G Allele of APOA4 rs5104
SO JOURNAL OF MOLECULAR NEUROSCIENCE
LA English
DT Article
DE Apolipoprotein A4; Depression; Single nucleotide polymorphism; Lipids;
   Glucose
ID APOLIPOPROTEIN-A-IV; LOW-DENSITY-LIPOPROTEIN; HDL-CHOLESTEROL LEVELS;
   GENE-CLUSTER; METABOLIC SYNDROME; SERUM; RISK; POLYMORPHISMS;
   BIOMARKERS; DISORDER
AB The association of apolipoprotein AIV (APOA4) with depression or plasma levels of lipids and glucose has been inconsistently reported. However, interplays between APOA4 and depression on the levels have not been explored yet. The present study aimed to investigate plasma levels of APOA4, lipids, and glucose in adolescents with different genotypes of APOA4 rs5104 and with or without depression. Depressive symptoms were assessed in 631 adolescents by Beck Depression Inventory (BDI). A total score of 14 was defined as the cutoff point for depression. Plasma levels of triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), glucose, and insulin were measured by routine methods, and APOA4 by enzyme-linked immunosorbent assays. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism analyses and verified by DNA sequencing. Female adolescents had higher prevalence of depression than male subjects only in G allele carriers (p = 0.015), but not in AA homozygotes. Risk factors of depression and predictors of depression severity were different between G allele carriers and AA homozygotes. Lower levels of glucose (p = 0.003) were observed in male G allele carriers than those in male AA homozygotes and increased TG levels (p = 0.008) in female G allele carriers when compared with those in female AA homozygotes. When both APOA4 rs5104 and depression were taken into account, subjects with depression had higher levels of plasma APOA4 than adolescents without depression only in female G allele carriers (p = 0.043), but no significant changes of plasma lipids and glucose. Depression augments plasma APOA4 levels without changes of plasma lipids and glucose in female adolescents carrying G allele of APOA4 rs5104. These results may provide a novel explanation for the inconsistent relationship between depression, APOA4, and plasma levels of lipids and glucose in the literature.
C1 [Guo, Qi Wei; Si, Yan Jun; Shen, Yi Lin; Chen, Xu; Yang, Mei; Fang, Ding Zhi; Lin, Jia] Sichuan Univ, West China Sch Basic Med Sci & Forens Med, Dept Biochem & Mol Biol, Chengdu, Peoples R China.
C3 Sichuan University
RP Lin, J (corresponding author), Sichuan Univ, West China Sch Basic Med Sci & Forens Med, Dept Biochem & Mol Biol, Chengdu, Peoples R China.
EM jialin@scu.edu.cn
RI Shen, Yilin/AAG-1724-2020; 斯, 艳君/HIR-1437-2022
OI Lin, Jia/0000-0001-6497-4267
FU National Natural Science Foundation of China [81974043]
FX This work was supported by the National Natural Science Foundation of
   China (Grant No. 81974043). Professor Ding Zhi Fang is the recipient of
   the grant.
CR AlBekairy A, 2017, MED PRIN PRACT, V26, P547, DOI 10.1159/000484929
   Arnold SE, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2011.63
   Bai W, 2019, PEERJ, V6, DOI 10.7717/peerj.6175
   Belmaker RH, 2008, NEW ENGL J MED, V358, P55, DOI [10.1056/NEJMra073096, 10.1038/nrdp.2016.65]
   Bot M, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.88
   BROWN SL, 1994, BRIT MED J, V308, P1328, DOI 10.1136/bmj.308.6940.1328
   Carboni L, 2010, PROG NEURO-PSYCHOPH, V34, P1037, DOI 10.1016/j.pnpbp.2010.05.019
   Chan MK, 2016, J PSYCHIATR RES, V83, P249, DOI 10.1016/j.jpsychires.2016.08.020
   Deng XD, 2012, STRUCTURE, V20, P767, DOI 10.1016/j.str.2012.02.020
   Dennis PA, 2014, J PSYCHOSOM RES, V77, P45, DOI 10.1016/j.jpsychores.2014.05.001
   Diniz BS, 2016, J PSYCHIATR RES, V82, P1, DOI 10.1016/j.jpsychires.2016.07.006
   Dortland AKBV, 2010, ACTA PSYCHIAT SCAND, V122, P30, DOI 10.1111/j.1600-0447.2010.01565.x
   Fall T, 2015, DIABETES, V64, P1841, DOI 10.2337/db14-0988
   Garasto S, 2003, ANN HUM GENET, V67, P54, DOI 10.1046/j.1469-1809.2003.00008.x
   Herron KL, 2006, ATHEROSCLEROSIS, V184, P113, DOI 10.1016/j.atherosclerosis.2005.03.023
   Kamboh MI, 1996, HUM BIOL, V68, P231
   KARATHANASIS SK, 1985, P NATL ACAD SCI USA, V82, P6374, DOI 10.1073/pnas.82.19.6374
   Kim JD, 2016, ENDOCRINOL METAB, V31, P320, DOI 10.3803/EnM.2016.31.2.320
   Kohan AB, 2012, AM J PHYSIOL-GASTR L, V302, pG628, DOI 10.1152/ajpgi.00225.2011
   Lamina C, 2016, HUM MOL GENET, V25, P3635, DOI 10.1093/hmg/ddw211
   Lee KW, 2019, GENES-BASEL, V10, DOI 10.3390/genes10120988
   Lee S, 2016, BMC GERIATR, V16, DOI 10.1186/s12877-016-0202-9
   Lefevre M, 2000, INT J OBESITY, V24, P945, DOI 10.1038/sj.ijo.0801260
   Li XM, 2017, SCI REP-UK, V7, DOI 10.1038/srep41289
   Li XM, 2014, J BIOL CHEM, V289, P2396, DOI 10.1074/jbc.M113.511766
   Lin Q, 2015, DRUG DES DEV THER, V9, P5421, DOI [10.2147/DDDT.589279, 10.2147/DDDT.S89279]
   Liu YJ, 2009, PHARMACOGENET GENOM, V19, P161, DOI 10.1097/FPC.0b013e32831e030e
   Miltiadous G, 2005, NUTR METAB CARDIOVAS, V15, P219, DOI 10.1016/j.numecd.2004.09.004
   Olusi SO, 1996, BIOL PSYCHIAT, V40, P1128, DOI 10.1016/S0006-3223(95)00599-4
   Ota VK, 2011, J INVEST MED, V59, P966, DOI 10.2310/JIM.0b013e31822467cd
   Ou HJ, 2015, GENET MOL RES, V14, P9277, DOI 10.4238/2015.August.10.8
   Peng R, 2017, J AFFECT DISORDERS, V217, P99, DOI 10.1016/j.jad.2017.03.055
   Persons JE, 2016, J AFFECT DISORDERS, V206, P55, DOI 10.1016/j.jad.2016.07.033
   Qi L, 2007, ATHEROSCLEROSIS, V192, P204, DOI 10.1016/j.atherosclerosis.2006.05.006
   Recalde D, 2004, ARTERIOSCL THROM VAS, V24, P756, DOI 10.1161/01.ATV.0000119353.03690.22
   Sevincok L, 2001, CAN J PSYCHIAT, V46, P68, DOI 10.1177/070674370104600110
   SHEK DTL, 1991, J CLIN PSYCHOL, V47, P381, DOI 10.1002/1097-4679(199105)47:3<381::AID-JCLP2270470309>3.0.CO;2-D
   Stefl S, 2013, J MOL BIOL, V425, P3919, DOI 10.1016/j.jmb.2013.07.014
   Stelzhammer V, 2014, INT J NEUROPSYCHOPH, V17, P1599, DOI 10.1017/S1461145714000819
   TENKANEN H, 1992, BIOCHIM BIOPHYS ACTA, V1138, P27, DOI 10.1016/0925-4439(92)90147-F
   Tso P, 2004, PHYSIOL BEHAV, V83, P631, DOI 10.1016/j.physbeh.2004.07.032
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Wang GQ, 2003, ANN HUM GENET, V67, P107, DOI 10.1046/j.1469-1809.2003.00023.x
   Wang Yu-lin, 2013, Zhongguo Yi Xue Ke Xue Yuan Xue Bao, V35, P416, DOI 10.3881/j.issn.1000-503X.2013.04.011
   Wang ZG, 2019, NUTR METAB, V16, DOI 10.1186/s12986-019-0367-2
   Wang ZY, 1997, CHINESE MED J-PEKING, V110, P264
   Wong WMR, 2007, ATHEROSCLEROSIS, V192, P266, DOI 10.1016/j.atherosclerosis.2006.07.017
   Wu YH, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0147946
   Youssef MM, 2018, INT J NEUROPSYCHOPH, V21, P528, DOI 10.1093/ijnp/pyy008
   Yu M, 2015, CAN J DIABETES, V39, P266, DOI 10.1016/j.jcjd.2014.11.006
   Zhan Y, 2014, EUR PSYCHIAT, V29, P307, DOI 10.1016/j.eurpsy.2014.03.004
NR 51
TC 5
Z9 5
U1 2
U2 18
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0895-8696
EI 1559-1166
J9 J MOL NEUROSCI
JI J. Mol. Neurosci.
PD OCT
PY 2021
VL 71
IS 10
BP 2060
EP 2070
DI 10.1007/s12031-020-01766-7
EA JAN 2021
PG 11
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA WD9IN
UT WOS:000605137900002
PM 33403595
DA 2025-06-11
ER

PT J
AU Romeo, J
   Wärnberg, J
   Gómez-Martínez, S
   Díaz, LE
   Marcos, A
AF Romeo, Javier
   Warnberg, Julia
   Gomez-Martinez, Sonia
   Esperanza Diaz, Ligia
   Marcos, Ascension
TI Neuroimmunomodulation by Nutrition in Stress Situations
SO NEUROIMMUNOMODULATION
LA English
DT Article
DE Nutrition; Stress; Immune system; Neuroendocrine system
ID PITUITARY-ADRENAL-AXIS; METABOLIC SYNDROME; DIETARY RESTRAINT;
   RESPONSES; CORTISOL; IMMUNITY; HORMONES; OBESITY; WOMEN; HUMANS
AB Stress has long been suspected to play a role in the etiology of many diseases and may be detrimental to health. Nowadays, the communication between the neuroendocrine and the immune systems is well established and there is enough evidence that the magnitude of stress-associated immune dysregulation is large enough to have health implications. In stress conditions, modulation of the immune system by the central nervous system (CNS) is mediated by a complex network of signals, showing a relationship between stress and resistance to infection. On the other hand, an adequate balanced diet plays a crucial role in the management of stress, and nutrition seems to be a critical determinant in the interactions among CNS and the immune system under stress conditions. Thus, interactions among nutrition, CNS and the immune system could be a key to understand implications in physiological stress situations. The present article will briefly review nutrition approaches on stress-related immune response and CNS communication. Copyright (c) 2008 S. Karger AG, Basel
C1 [Romeo, Javier; Warnberg, Julia; Gomez-Martinez, Sonia; Esperanza Diaz, Ligia; Marcos, Ascension] Sci Natl Res Council CSIC, ICTAN, Inst Frio, Immunonutr Res Grp,Dept Metab & Nutr, Madrid, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Ciencia y Tecnologia de Alimentos y Nutricion (ICTAN)
RP Romeo, J (corresponding author), CSIC, Inst Frio, Grp Inmunonutr, Dept Metab & Nutr, Calle Jose Antonio Novais 10, ES-28040 Madrid, Spain.
EM jromeo@if.csic.es
RI Sanchez, Ascension/K-4965-2014; Gómez Martínez, Sonia/Q-2626-2017;
   Warnberg, Julia/G-1390-2011
OI Warnberg, Julia/0000-0002-8408-316X
CR Adam TC, 2007, PHYSIOL BEHAV, V91, P449, DOI 10.1016/j.physbeh.2007.04.011
   Bassit RA, 2000, MED SCI SPORT EXER, V32, P1214, DOI 10.1097/00005768-200007000-00005
   Benschop RJ, 1996, FASEB J, V10, P517, DOI 10.1096/fasebj.10.4.8647351
   Björntorp P, 1999, ANN NY ACAD SCI, V892, P297, DOI 10.1111/j.1749-6632.1999.tb07803.x
   BUTTS CL, 2008, CELL IMMUNOL
   Calder PC, 2002, BRIT J NUTR, V88, pS165, DOI 10.1079/BJN2002682
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   Dhabhar FS, 1999, P NATL ACAD SCI USA, V96, P1059, DOI 10.1073/pnas.96.3.1059
   Dhabhar FS, 2000, ANN NY ACAD SCI, V917, P876, DOI 10.1111/j.1749-6632.2000.tb05454.x
   DHABHAR FS, 1995, J IMMUNOL, V154, P5511
   Eskandari F, 2003, ARTHRITIS RES THER, V5, P251, DOI 10.1186/ar1002
   Ferroni Patrizia, 2004, Curr Atheroscler Rep, V6, P424, DOI 10.1007/s11883-004-0082-x
   Gluck ME, 2006, APPETITE, V46, P26, DOI 10.1016/j.appet.2005.05.004
   Gluck ME, 2004, PSYCHOSOM MED, V66, P876, DOI 10.1097/01.psy.0000143637.63508.47
   Gruenwald J, 2002, ADV THER, V19, P141, DOI 10.1007/BF02850270
   Hamer M, 2004, J AM COLL NUTR, V23, P637, DOI 10.1080/07315724.2004.10719405
   HERBERT TB, 1993, PSYCHOSOM MED, V55, P364, DOI 10.1097/00006842-199307000-00004
   Klein T W, 1993, J Fla Med Assoc, V80, P409
   Komaki G, 1997, AM J CLIN NUTR, V66, P147, DOI 10.1093/ajcn/66.1.147
   Lattimore PJ, 2001, APPETITE, V36, P187, DOI 10.1006/appe.2000.0387
   Lippolis JD, 2008, J ANIM SCI, V86, P2430, DOI 10.2527/jas.2008-0921
   Makino S, 2002, PHARMACOL BIOCHEM BE, V73, P147, DOI 10.1016/S0091-3057(02)00791-8
   Marcos A, 2003, EUR J CLIN NUTR, V57, pS66, DOI 10.1038/sj.ejcn.1601819
   McTiernan A, 2000, CANCER-AM CANCER SOC, V88, P1248, DOI 10.1002/(SICI)1097-0142(20000301)88:5+<1248::AID-CNCR12>3.0.CO;2-1
   MORMEDE P, 1990, PHYSIOL BEHAV, V47, P1099, DOI 10.1016/0031-9384(90)90358-B
   Nieuwenhuizen AG, 2008, PHYSIOL BEHAV, V94, P169, DOI 10.1016/j.physbeh.2007.12.011
   Okasaka Y, 2008, PSYCHIAT CLIN NEUROS, V62, P84, DOI 10.1111/j.1440-1819.2007.01779.x
   Olff M, 1999, PSYCHIAT RES, V85, P7, DOI 10.1016/S0165-1781(98)00139-5
   Oliver G, 1999, PHYSIOL BEHAV, V66, P511, DOI 10.1016/S0031-9384(98)00322-9
   Pasquali R, 1996, METABOLISM, V45, P351, DOI 10.1016/S0026-0495(96)90290-5
   Reinehr T, 2004, HORM RES, V62, P107, DOI 10.1159/000079841
   Roemmich JN, 2002, OBES RES, V10, P1120, DOI 10.1038/oby.2002.152
   Rojo L, 2006, PSYCHOSOM MED, V68, P628, DOI 10.1097/01.psy.0000227749.58726.41
   Rosmond R, 1998, J CLIN ENDOCR METAB, V83, P1853, DOI 10.1210/jc.83.6.1853
   Shephard RJ, 2002, CRIT REV IMMUNOL, V22, P165
   Sims Regina, 2008, Eat Behav, V9, P137, DOI 10.1016/j.eatbeh.2007.06.006
   Tripathy D, 2003, DIABETES, V52, P2882, DOI 10.2337/diabetes.52.12.2882
   Walrand S, 2001, AM J CLIN NUTR, V74, P670
   Wardle J, 2000, J PSYCHOSOM RES, V48, P195, DOI 10.1016/S0022-3999(00)00076-3
   Wärnberg J, 2007, BRIT J NUTR, V98, pS116, DOI 10.1017/S0007114507839614
   Wärnberg J, 2006, AM J CLIN NUTR, V84, P505
   WEIGENSBERG MJ, 2008, J CLIN ENDOCRINOL ME
   Yang EV, 2002, INT IMMUNOPHARMACOL, V2, P315, DOI 10.1016/S1567-5769(01)00182-5
NR 44
TC 7
Z9 7
U1 1
U2 19
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1021-7401
EI 1423-0216
J9 NEUROIMMUNOMODULAT
JI Neuroimmunomodulation
PY 2008
VL 15
IS 3
BP 165
EP 169
DI 10.1159/000153420
PG 5
WC Endocrinology & Metabolism; Immunology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Neurosciences & Neurology
GA 358BX
UT WOS:000259892600004
PM 18781080
DA 2025-06-11
ER

PT J
AU Piegza, M
   Badura-Brzoza, K
   Pudlo, R
   Piegza, J
   Kunert, L
   Jaworska, I
   Sobis, J
   Blachut, M
   Gorczyca, PW
AF Piegza, Magdalena
   Badura-Brzoza, Karina
   Pudlo, Robert
   Piegza, Jacek
   Kunert, Lukasz
   Jaworska, Izabela
   Sobis, Jaroslaw
   Blachut, Michal
   Gorczyca, Piotr W.
TI The sense of coherence in women undergoing coronary arteriography
SO PSYCHIATRIA POLSKA
LA English
DT Article
DE coronary artery disease; sense of coherence; cardiac syndrome X
ID QUALITY-OF-LIFE; HEART-DISEASE; HEALTH; POPULATION; PREDICTOR
AB Aim. The examination referred to two groups of female patients: with and without significant coronary stenoses in coronarography. There were two stages of the examination: before and 6-9 months after coronarography. The factor dividing patients into two groups: without significant atheromatosis and with coronary atheromatosis, was the result of invasive diagnostics of coronary heart disease.
   Methods. The sense of coherence scale (SOC-29) and sociodemographic questionnaires were used to evaluate the condition of the two groups.
   Results. In group of patients with irrelevant coronary stenoses statistically lower values of sense of comprehension were noticed in the first and the second examination and also statistically lower values of sense of manage were observed, comparing to the group of patients with significant stenoses. The initial value of general coherence was comparable in both groups and did not significantly change in 6-9 months after coronarography. The characteristic parameters: lack of social support, intensity of depressiveness and anxiety before getting information about necessity of coronarography and worse education were connected with lower sense of coherence.
   Conclusions. The baseline strength of the total sense of coherence was not different between groups. Patients with no significant stenosis of coronary arteries demonstrate a lower sense of comprehensibility before and after the coronary arteriography and lower sense of manageability after the procedure compared to the group of patients with significant atherosclerotic lesions. No social support, tendency for depression and anxiety and lower level of education
C1 [Piegza, Magdalena; Badura-Brzoza, Karina; Pudlo, Robert; Kunert, Lukasz; Sobis, Jaroslaw; Blachut, Michal; Gorczyca, Piotr W.] Med Univ Silesia, Dept & Clin Psychiat, Tarnowskie Gory, Poland.
   [Piegza, Jacek; Jaworska, Izabela] SCCS, Dept Cardiol 3, Zabrze, Poland.
C3 Medical University of Silesia
RP Kunert, L (corresponding author), Silesian Med Sch, Fac Med Zabrze, Chair & Dept Psychiat, Div Dent, Ul Pyskowicka 49, PL-42612 Tarnowskie Gory, Poland.
RI Pudlo, Robert/HKF-1660-2023
OI Pudlo, Robert/0000-0002-5748-0063; Blachut, Michal/0000-0002-4438-2376;
   Jaworska, Izabela/0000-0001-5090-2385
CR ANTONOVSKY A, 1985, ISR J PSYCHIATR REL, V22, P273
   Antonovsky A., 1995, ROZWIKLANIE TAJEMNIC
   Blom M, 2003, J CARDIOVASC RISK, V10, P201, DOI 10.1097/00043798-200306000-00008
   Flensborg-Madsen T, 2005, THESCIENTIFICWORLDJO, V5, P665, DOI 10.1100/tsw.2005.85
   Jackowska Ewa, 2004, Psychiatr Pol, V38, P37
   Kaski Juan Carlos, 2004, Am J Cardiovasc Drugs, V4, P179, DOI 10.2165/00129784-200404030-00005
   Kattainen Eija, 2006, Eur J Cardiovasc Nurs, V5, P21, DOI 10.1016/j.ejcnurse.2005.05.001
   KENNEDY JW, 1982, CIRCULATION, V66, P16
   Krantz G, 2004, INT J BEHAV MED, V11, P18, DOI 10.1207/s15327558ijbm1101_3
   LERNER DJ, 1986, AM HEART J, V111, P383, DOI 10.1016/0002-8703(86)90155-9
   Lindström B, 2005, J EPIDEMIOL COMMUN H, V59, P440, DOI 10.1136/jech.2005.034777
   Lisk CJ, 1999, WOMEN HEALTH, V29, P31, DOI 10.1300/J013v29n01_03
   Lockyer Lesley, 2005, Eur J Cardiovasc Nurs, V4, P29, DOI 10.1016/j.ejcnurse.2004.09.003
   Mosca L, 1997, CIRCULATION, V96, P2468
   Mroziak B, 1997, Psychiatr Pol, V31, P257
   Nilsson B, 2003, SCAND J PUBLIC HEALT, V31, P297, DOI 10.1080/14034940210164920
   Opolski G., 2001, CHOROBA NIEDOKRWIENN, VI
   Piegza M, 2008, PSYCHIATR POL, V42, P229
   Popiolek K., 2004, LEK DEPRESJA, V9, P97
   Rzeczuch K, 1996, KARDIOL POL, V45, P198
   Silarova B, 2012, QUAL LIFE RES, V21, P1863, DOI 10.1007/s11136-011-0106-2
   Snekkevik H, 2003, CLIN REHABIL, V17, P443, DOI 10.1191/0269215503cr630oa
   Spila Bozena, 2005, Psychiatr Pol, V39, P115
   SWIATECKA G, 2000, CHOROBY SERCA KOBIET
   WENGER N, 1993, CARDIOVASCULAR HLTH, P28
   Wrzesniewski K, 2012, KARDIOL POL, V70, P157
NR 26
TC 4
Z9 5
U1 0
U2 9
PU WYDAWNICZY POLSKIEGO TOWARZYSTWA
PI CRACOW
PA LENARTOWICZA 14 STRREET,, CRACOW, 31-138, POLAND
SN 0033-2674
J9 PSYCHIATR POL
JI Psychiatr. Pol.
PY 2014
VL 48
IS 5
BP 975
EP 986
DI 10.12740/PP/24452
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA AW9SD
UT WOS:000346596500008
PM 25639017
OA gold
DA 2025-06-11
ER

PT J
AU Fiedorowicz, JG
   Palagummi, NM
   Behrendtsen, O
   Coryell, WH
AF Fiedorowicz, Jess G.
   Palagummi, Narasimha M.
   Behrendtsen, Ole
   Coryell, William H.
TI Cholesterol and affective morbidity
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Cholesterol; Major depression; Bipolar disorder; Mania; Depression
ID MAJOR DEPRESSIVE DISORDER; RESEARCH DIAGNOSTIC CRITERIA; CARDIOVASCULAR
   RISK-FACTORS; SERUM-CHOLESTEROL; BIPOLAR-DISORDER; MEMBRANE CHOLESTEROL;
   PLASMA-CHOLESTEROL; SUICIDE ATTEMPTERS; METABOLIC SYNDROME; MOOD
   DISORDERS
AB Depression and mania have been linked with low cholesterol though there has been limited prospective study of cholesterol and subsequent course of affective illness. We studied the relationship between fasting total cholesterol and subsequent depressive and manic symptoms. A total of 131 participants from a prospective cohort study were identified as having had a fasting total cholesterol evaluation at intake. Participants were predominantly inpatients at index visit and were followed for a median of 20 and up to 25 years. Cholesterol was modeled with age, gender, and index use of a mood stabilizer in linear regression to assess its influence on subsequent depressive symptom burden in participants with unipolar disorder as well as depressive and manic symptom burden in participants with bipolar disorder. Among bipolar participants (N = 65), low cholesterol predicted a higher proportion of follow-up weeks with manic, but not depressive symptoms. Cholesterol did not appear to predict depressive symptom burden among participants with unipolar depression (N = 66). Lower cholesterol levels may predispose individuals with bipolar disorder to a greater burden of manic symptomatology and may provide some insight into the underlying neurobiology. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
C1 [Fiedorowicz, Jess G.; Behrendtsen, Ole; Coryell, William H.] Univ Iowa, Dept Psychiat, Roy J & Lucille A Carver Coll Med, Iowa City, IA 52242 USA.
   [Behrendtsen, Ole] Univ Iowa, Dept Internal Med, Roy J & Lucille A Carver Coll Med, Iowa City, IA 52242 USA.
   [Palagummi, Narasimha M.] Marshalltown Med Clin, Marshalltown, IA USA.
C3 University of Iowa; University of Iowa
RP Fiedorowicz, JG (corresponding author), 200 Hawkins Dr,W278GH, Iowa City, IA 52242 USA.
EM jess-fiedorowicz@uiowa.edu
RI Fiedorowicz, Jess/I-2512-2019
OI coryell, william/0000-0003-3989-7276; Fiedorowicz,
   Jess/0000-0003-2057-4071
FU NIMH [MH 25416]; Nellie Ball Trust Research Fund [L30 MH075180-02];
   NARSAD
FX This study was funded by NIMH grant MH 25416. Dr. Fiedorowicz is
   supported by L30 MH075180-02, the Nellie Ball Trust Research Fund, and a
   NARSAD Young Investigator Award. He has received research support for
   participating in a colleague's investigator-initiated study with Eli
   Lilly. The authors have no potential conflicts of interest, financial or
   otherwise. The authors thank Carol Moss and Barbara Robb for assistance
   with data management as well as Myra Fiedorowicz and Lois Warren for
   assistance with manuscript editing.
CR Abulrob A, 2005, J NEUROCHEM, V92, P1477, DOI 10.1111/j.1471-4159.2005.03001.x
   Arnett DK, 2002, AM J EPIDEMIOL, V156, P929, DOI 10.1093/aje/kwf133
   Atmaca M, 2002, NEUROPSYCHOBIOLOGY, V46, P176, DOI 10.1159/000067809
   Beasley CL, 2005, BIPOLAR DISORD, V7, P449, DOI 10.1111/j.1399-5618.2005.00239.x
   BERNS MAM, 1988, INT J EPIDEMIOL, V17, P789, DOI 10.1093/ije/17.4.789
   Bocchetta A, 2001, ACTA PSYCHIAT SCAND, V104, P37, DOI 10.1034/j.1600-0447.2001.00374.x
   Butchbach MER, 2004, J BIOL CHEM, V279, P34388, DOI 10.1074/jbc.M403938200
   Cassidy F, 2002, EUR ARCH PSY CLIN N, V252, P110, DOI 10.1007/s00406-002-0367-4
   Chung KH, 2007, PSYCHIAT CLIN NEUROS, V61, P428, DOI 10.1111/j.1440-1819.2007.01689.x
   Coryell W, 2003, ARCH GEN PSYCHIAT, V60, P914, DOI 10.1001/archpsyc.60.9.914
   Coryell W, 2007, PSYCHIAT RES, V150, P187, DOI 10.1016/j.psychres.2006.01.021
   Deisenhammer EA, 2004, PSYCHIAT RES, V121, P253, DOI 10.1016/j.psychres.2003.09.007
   Diaz-Sastre C, 2007, PROG NEURO-PSYCHOPH, V31, P901, DOI 10.1016/j.pnpbp.2007.02.004
   Ellison LF, 2001, EPIDEMIOLOGY, V12, P168, DOI 10.1097/00001648-200103000-00007
   ENDICOTT J, 1979, AM J PSYCHIAT, V136, P52
   ENDICOTT J, 1978, ARCH GEN PSYCHIAT, V35, P837
   ENGSTROM G, 1995, SUICIDE LIFE-THREAT, V25, P393
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   Fiedorowicz JG, 2009, PSYCHOL MED, V39, P763, DOI 10.1017/S0033291708004078
   Fiedorowicz JG, 2007, PSYCHIAT RES, V152, P11, DOI 10.1016/j.psychres.2006.09.003
   Fiedorowicz JG, 2008, ANN CLIN PSYCHIATRY, V20, P131, DOI 10.1080/10401230802177722
   Frank C, 2004, FEBS LETT, V566, P25, DOI 10.1016/j.febslet.2004.03.113
   Gabriel A, 2007, J AFFECT DISORDERS, V99, P273, DOI 10.1016/j.jad.2006.08.015
   Ghaemi SN, 2000, BIPOLAR DISORD, V2, P60, DOI 10.1034/j.1399-5618.2000.020109.x
   Gil C, 2006, BIOCHEM BIOPH RES CO, V348, P1334, DOI 10.1016/j.bbrc.2006.07.201
   GLUECK CJ, 1994, AM J MED SCI, V308, P218
   GOLIER JA, 1995, AM J PSYCHIAT, V152, P419
   Golomb BA, 2002, J CLIN EPIDEMIOL, V55, P767, DOI 10.1016/S0895-4356(02)00407-9
   Huang P, 2007, BIOCHEM PHARMACOL, V73, P534, DOI 10.1016/j.bcp.2006.10.032
   Jow GM, 2006, J AFFECT DISORDERS, V90, P21, DOI 10.1016/j.jad.2005.09.015
   Judd LL, 2003, INT J NEUROPSYCHOPH, V6, P127, DOI 10.1017/S1461145703003341
   Judd LL, 1998, J AFFECT DISORDERS, V50, P97, DOI 10.1016/S0165-0327(98)00138-4
   KELLER MB, 1987, ARCH GEN PSYCHIAT, V44, P540
   Kopf D, 2004, J CLIN PSYCHOPHARM, V24, P527, DOI 10.1097/01.jcp.0000138762.23482.63
   LINDBERG G, 1992, BRIT MED J, V305, P277, DOI 10.1136/bmj.305.6848.277
   Maes M, 1999, PSYCHIAT RES, V85, P275, DOI 10.1016/S0165-1781(99)00014-1
   MORGAN RE, 1993, LANCET, V341, P75, DOI 10.1016/0140-6736(93)92556-9
   MULDOON MF, 1990, BMJ-BRIT MED J, V301, P309, DOI 10.1136/bmj.301.6747.309
   Nakao M, 2004, TOHOKU J EXP MED, V204, P273, DOI 10.1620/tjem.204.273
   NEATON JD, 1992, ARCH INTERN MED, V152, P1490, DOI 10.1001/archinte.152.7.1490
   Olusi SO, 1996, BIOL PSYCHIAT, V40, P1128, DOI 10.1016/S0006-3223(95)00599-4
   OXENKRUG GF, 1983, AM J PSYCHIAT, V140, P920
   Pae CU, 2004, J AFFECT DISORDERS, V83, P79, DOI 10.1016/j.jad.2004.04.010
   Papakostas GI, 2004, J CLIN PSYCHOPHARM, V24, P467, DOI 10.1097/01.jcp.0000132343.58584.1d
   Papakostas GI, 2003, PSYCHIAT RES, V118, P137, DOI 10.1016/S0165-1781(03)00066-0
   Papakostas GI, 2003, NEUROPSYCHOBIOLOGY, V47, P146, DOI 10.1159/000070584
   Partonen T, 1999, BRIT J PSYCHIAT, V175, P259, DOI 10.1192/bjp.175.3.259
   Sagud M, 2007, J AFFECT DISORDERS, V97, P247, DOI 10.1016/j.jad.2006.05.030
   Scanlon SM, 2001, BIOCHEMISTRY-US, V40, P10507, DOI 10.1021/bi010730z
   Singh P, 2007, BIOCHEM BIOPH RES CO, V358, P495, DOI 10.1016/j.bbrc.2007.04.135
   Sjogren B, 2006, EUR J PHARMACOL, V552, P1, DOI 10.1016/j.ejphar.2006.08.069
   Solomon DA, 2003, AM J PSYCHIAT, V160, P2049, DOI 10.1176/appi.ajp.160.11.2049
   Sooksawate T, 2001, BRIT J PHARMACOL, V134, P1303, DOI 10.1038/sj.bjp.0704360
   Sooksawate T, 2001, NEUROPHARMACOLOGY, V40, P178, DOI 10.1016/S0028-3908(00)00159-3
   SPITZER RL, 1978, ARCH GEN PSYCHIAT, V35, P773, DOI 10.1001/archpsyc.1978.01770300115013
   SWARTZ CM, 1990, J AFFECT DISORDERS, V19, P173, DOI 10.1016/0165-0327(90)90088-P
   Volek JS, 2002, EUR J CLIN NUTR, V56, P585, DOI 10.1038/sj.ejcn.1601362
NR 57
TC 18
Z9 19
U1 0
U2 1
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD JAN
PY 2010
VL 175
IS 1-2
BP 78
EP 81
DI 10.1016/j.psychres.2009.01.001
PG 4
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 553NT
UT WOS:000274374800015
PM 19969372
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Aciksari, G
   Demir, B
   Uygun, T
   Gedikbasi, A
   Kutlu, O
   Atici, A
   Baycan, OF
   Kocak, M
   Kul, S
AF Aciksari, Gonul
   Demir, Bulent
   Uygun, Turgut
   Gedikbasi, Asuman
   Kutlu, Orkide
   Atici, Adem
   Baycan, Omer Faruk
   Kocak, Mehmet
   Kul, Seref
TI Serum prolidase activity in patients with cardiac syndrome X
SO NORTHERN CLINICS OF ISTANBUL
LA English
DT Article
DE Cardiac syndrome X; collagen; serum prolidase activity
ID CORONARY-ARTERY-DISEASE; ANGINA-PECTORIS; CHEST-PAIN;
   EXTRACELLULAR-MATRIX; OXIDATIVE STRESS; ASSOCIATION
AB OBJECTIVE: Although the underlying mechanism is not yet fully understood, Cardiac Syndrome X (CSX) is defined as microvascular dysfunction. Prolidase plays a role in collagen synthesis. Increased serum prolidase activity (SPA) has been shown to correlate with collagen turnover. Augmented collagen turn-over may be associated with vascular fibrosis and microvascular dysfunction. In this study, we assessed whether there was a correlation between CXS and prolidase activity.
   METHODS: This case-control study included 45 consecutive CSX patients (mean age 50.7 +/- 6.5 years, 27 women) and 40 healthy controls (mean age 51.2 +/- 6.5 years, 25 women). Prolidase activity was determined with the Human Xaa-Pro Dipeptidase/Prolidase enzyme-linked immunosorbent assay kit (Cusabio Biotech Co. Ltd, China).
   RESULTS: Mean prolidase activity was 898.8 +/- 639.1 mU/mL in the CSX group and 434.1 +/- 289.8 mU/mL in the control group (p<0.001). In ROC analysis, it was found that the SPA value above 350 mU/mL sympathizes with the diagnosis of CSX.
   CONCLUSION: Increased SPA in CXS patients may play an essential role in the pathophysiology of CSX, leading to augmented oxidative stress and vascular fibrosis, endothelial dysfunction, and increased microvascular resistance.
C1 [Aciksari, Gonul; Atici, Adem; Baycan, Omer Faruk; Kul, Seref] Istanbul Medeniyet Univ, Dept Cardiol, Gortepe Training & Res Hosp, Istanbul, Turkey.
   [Demir, Bulent] Bakirkoy Dr Sadi Konuk Training & Res Hosp, Dept Cardiol, Istanbul, Turkey.
   [Uygun, Turgut] Konya Training & Res Hosp, Dept Cardiol, Konya, Turkey.
   [Gedikbasi, Asuman] Bakirkoy Dr Sadi Konuk Training & Res Hosp, Dept Biochem, Istanbul, Turkey.
   [Kutlu, Orkide] Okmeydani Training & Res Hosp, Dept Internal Med, Istanbul, Turkey.
   [Kocak, Mehmet] Fatih Sultan Mehmet Training & Res Hosp, Dept Emergency Med, Istanbul, Turkey.
C3 Istanbul Medeniyet University; Bakirkoy Dr. Sadi Konuk Research &
   Training Hospital; Konya Egitim Training & Research Hospital; Bakirkoy
   Dr. Sadi Konuk Research & Training Hospital; Istanbul Okmeydani Training
   & Research Hospital; Fatih Sultan Mehmet Training & Research Hospital
RP Aciksari, G (corresponding author), Istanbul Medeniyet Univ, Dept Cardiol, Gortepe Training & Res Hosp, Istanbul, Turkey.
EM drgonulkutlu@hotmail.com
RI Baycan, Omer/GSI-6455-2022; Demir, Bulent/KVC-1688-2024; aciksari,
   gonul/LXW-1995-2024; Gedikbasi, Asuman/AAE-3613-2020; kul,
   seref/KSL-9750-2024; Kocak, Mehmet/AAE-2382-2019
OI Demir, Bulent/0000-0003-1767-408X; Kocak, Mehmet/0000-0003-0782-390X
CR Aktürk E, 2018, ANATOL J CARDIOL, V19, P110, DOI 10.14744/AnatolJCardiol.2017.8160
   Altindag O, 2007, RHEUMATOL INT, V27, P339, DOI 10.1007/s00296-006-0247-8
   Arroyo-Espliguero R, 2003, EUR HEART J, V24, P2006, DOI 10.1016/j.ehj.2003.09.029
   Bozcali E, 2014, ATHEROSCLEROSIS, V237, P259, DOI 10.1016/j.atherosclerosis.2014.09.014
   Bugiardini R, 2004, CIRCULATION, V109, P2518, DOI 10.1161/01.CIR.0000128208.22378.E3
   CANNON RO, 1988, AM J CARDIOL, V61, P1338, DOI 10.1016/0002-9149(88)91180-0
   Cox ID, 2000, CLIN CARDIOL, V23, P645
   Demir B, 2013, CLIN LAB, V59, P1319, DOI 10.7754/Clin.Lab.2013.121142
   Demirbag R, 2007, CLIN BIOCHEM, V40, P1020, DOI 10.1016/j.clinbiochem.2007.05.015
   Duong HS, 2006, BRIT J DERMATOL, V154, P820, DOI 10.1111/j.1365-2133.2006.07167.x
   EGASHIRA K, 1993, NEW ENGL J MED, V328, P1659, DOI 10.1056/NEJM199306103282302
   GALIS ZS, 1994, J CLIN INVEST, V94, P2493, DOI 10.1172/JCI117619
   Hilali N, 2013, CLIN ENDOCRINOL, V79, P105, DOI 10.1111/cen.12110
   Jespersen L, 2012, EUR HEART J, V33, P734, DOI 10.1093/eurheartj/ehr331
   Kappagoda CT, 2009, J CARDIOPULM REHABIL, V29, P207, DOI 10.1097/HCR.0b013e3181af6be5
   KEMP HG, 1973, AM J CARDIOL, V32, P375, DOI 10.1016/S0002-9149(73)80150-X
   Lakatta EG, 2013, ARTERY RES, V7, P73, DOI 10.1016/j.artres.2013.01.003
   MASERI A, 1991, J AM COLL CARDIOL, V17, P499, DOI 10.1016/S0735-1097(10)80122-6
   Morrow DA, 2012, BRAUNWALDS HEART DIS, P1210
   MYARA I, 1984, CLIN CHEM, V30, P211
   Palka JA, 1997, MOL CELL BIOCHEM, V168, P177
   Palka JA, 1997, J CELL BIOCHEM, V67, P166, DOI 10.1002/(SICI)1097-4644(19971101)67:2<166::AID-JCB2>3.0.CO;2-V
   Panting JR, 2002, NEW ENGL J MED, V346, P1948, DOI 10.1056/NEJMoa012369
   Pizzi C, 2004, CIRCULATION, V109, P53, DOI 10.1161/01.CIR.0000100722.34034.E4
   Rabus M, 2008, ARCH MED RES, V39, P519, DOI 10.1016/j.arcmed.2008.03.002
   Savas M, 2010, J ANDROL, V31, P146, DOI 10.2164/jandrol.109.008631
   Speranza L, 2008, INT J IMMUNOPATH PH, V21, P879, DOI 10.1177/039463200802100412
   Suner A, 2015, POSTEP KARDIOL INTER, V11, P206, DOI 10.5114/pwki.2015.54015
   Surazynski A, 2008, INT J CANCER, V122, P1435, DOI 10.1002/ijc.23263
   Tabur S, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-142
   Türkbeyler I, 2012, INFLAMMATION, V35, P1747, DOI 10.1007/s10753-012-9493-y
   Uzar E, 2012, NEUROL SCI, V33, P875, DOI 10.1007/s10072-011-0857-0
   Verma AK, 2014, BIOCHEM RES INT, V2014, DOI 10.1155/2014/291458
   Yamamoto S, 2002, CORONARY ARTERY DIS, V13, P25, DOI 10.1097/00019501-200202000-00004
   Yavuz C, 2013, TURK GOGUS KALP DAMA, V21, P1000, DOI 10.5606/tgkdc.dergisi.2013.7855
   Yildiz A, 2008, CORONARY ARTERY DIS, V19, P319, DOI 10.1097/MCA.0b013e32830042ba
   ZANABONI G, 1994, HAEMATOLOGICA, V79, P13
   Zeng B, 2005, INTERN MED J, V35, P331, DOI 10.1111/j.1445-5994.2005.00822.x
   Zorc-Pleskovic R, 2008, FOLIA BIOL-PRAGUE, V54, P30
NR 39
TC 3
Z9 3
U1 0
U2 6
PU KARE PUBL
PI ISTANBUL
PA CONCORD ISTANBUL, DUMLUPINAR MAH, CIHAN SK NO 15, B BLOK 162 KADIKOY,
   ISTANBUL, 00000, TURKEY
SN 2148-4902
J9 NORTH CLIN ISTANB
JI North. Clin. Istanb.
PY 2020
VL 7
IS 5
BP 471
EP 477
DI 10.14744/nci.2020.09086
PG 7
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA OC8BS
UT WOS:000579382100009
PM 33163883
OA Green Published
DA 2025-06-11
ER

PT J
AU Chen, YC
   Hou, CJY
   Tsai, CH
   Yeh, HI
AF Chen, Yung-Chih
   Hou, Charles Jia-Yin
   Tsai, Cheng-Ho
   Yeh, Hung-I
TI RELATIONSHIPS OF THE THROMBOLYSIS IN MYOCARDIAL INFARCTION FRAME COUNT
   WITH CLINICAL, HEMODYNAMIC AND MEDICINE VARIABLES IN SYNDROME X PATIENTS
SO INTERNATIONAL JOURNAL OF GERONTOLOGY
LA English
DT Article
DE microvascular dysfunction; syndrome X; TIMI frame count
ID CORONARY FLOW RESERVE; CONVERTING ENZYME-INHIBITION; LEFT-VENTRICULAR
   FUNCTION; ANGINA-PECTORIS; CHEST-PAIN; ARTERIOGRAMS; RESISTANCE; IMPACT;
   HEART
AB Background: The thrombolysis in myocardial infarction (TIMI) frame count was reported to reflect coronary blood flow and have prognostic value. However, such data in syndrome X was lacking. The purpose of this study was to examine the prognostic value of the TIMI frame count in syndrome X patients, compared with the normal population.
   Methods: The TIMI frame count was measured in 2,049 consecutive patients referred for coronaryangiography from March 2003 to February 2005.
   Results: Among 308 patients with normal coronary angiograms, 44 undergoing the procedure for electrophysiologic studies or valvular heart disease surveys other than angina were designated normal controls. Another 155 patients with positive stress test results were diagnosed as syndrome X. Comparisons of the two groups showed that the syndrome X patients had higher frame counts in the left anterior descending artery (40.9 +/- 15.7 vs. 47.8 +/- 25.4; p < 0.05) and left circumflex artery (35.2 +/- 11.7 vs. 42.0 +/- 18.7; p<0.05). A similar trend was found in the right coronary artery (29.3 +/- 13.5 vs. 31.9 +/- 15.9; p = 0.2). The TIMI frame count in each artery of the syndrome X group was related to the patients' variables (sex, age, and body mass index), clinical variables (medication use, diabetes, hypertension, hypercholesterolemia, smoking, and family history), and hemodynamic variables (aortic systolic blood pressure and left ventricular end-diastolic pressure). By multivariate analysis, the TIMI frame counts in all arteries were significantly higher in women and lower with angiotensin-converting enzyme inhibitor (ACEI) use (both p<0.05). The frame count in the left anterior descending was associated with diuretics use (p<0.05).
   Conclusion: Our TIMI frame count data confirm the presence of slow coronary flow in syndrome X patients, especially women. ACEI use shortens the counts in these patients, suggesting that ACEIs have the potential to correct the underlying hemodynamic defects in such patients. [International Journal of Gerontology 2008-2(3): 109-114]
C1 [Hou, Charles Jia-Yin; Tsai, Cheng-Ho; Yeh, Hung-I] Mackay Mem Hosp, Taipei 10449, Taiwan.
   [Chen, Yung-Chih] Taitung Mackay Mem Hosp, Dept Internal Med, Div Cardiovasc, Taipei, Taiwan.
   [Tsai, Cheng-Ho; Yeh, Hung-I] Taipei Med Univ, Mackay Med Nursing & Management Coll, Taipei, Taiwan.
C3 Mackay Memorial Hospital; Mackay Memorial Hospital; Taipei Medical
   University; Mackay Junior College of Medicine, Nursing & Management
RP Yeh, HI (corresponding author), Mackay Mem Hosp, 92,Sect 2 Chung San N Rd, Taipei 10449, Taiwan.
EM hiyeh@ms1.mmh.org.tw
FU Medical Research Department of the Mackay Memorial Hospital, Taiwan
   [MMH-9257, 94E-003]
FX This work was supported by grants MMH-9257 and 94E-003 from the Medical
   Research Department of the Mackay Memorial Hospital, Taiwan. The authors
   thank colleagues in the Cardiovascular Division for assistance in
   recruiting the study participants. The data collection by Hsin-Yu Chlu
   is appreciated.
CR Amos DJ, 2001, AM HEART J, V141, P586, DOI 10.1067/mhj.2001.113393
   Botker HE, 1997, AM J CARDIOL, V79, P1615, DOI 10.1016/S0002-9149(97)00209-9
   Chen JW, 2002, AM J CARDIOL, V90, P974, DOI 10.1016/S0002-9149(02)02664-4
   Dodge JT, 1998, AM J CARDIOL, V81, P1268, DOI 10.1016/S0002-9149(98)00138-6
   DODGE JT, 1988, CIRCULATION, V78, P1167, DOI 10.1161/01.CIR.78.5.1167
   EGASHIRA K, 1993, NEW ENGL J MED, V328, P1659, DOI 10.1056/NEJM199306103282302
   Faile BA, 2000, AM HEART J, V140, P308, DOI 10.1067/mhj.2000.108003
   Ferrara L, 1998, Minerva Cardioangiol, V46, P181
   French J. K., 1998, European Heart Journal, V19, P630
   French JK, 1998, AUST NZ J MED, V28, P569, DOI 10.1111/j.1445-5994.1998.tb02113.x
   French JK, 1999, HEART, V81, P128, DOI 10.1136/hrt.81.2.128
   Gibson CM, 1996, CIRCULATION, V93, P879, DOI 10.1161/01.CIR.93.5.879
   Gibson CM, 1999, CIRCULATION, V99, P1945, DOI 10.1161/01.CIR.99.15.1945
   Kaski JC, 2004, CIRCULATION, V109, P568, DOI 10.1161/01.CIR.0000116601.58103.62
   KASKI JC, 1995, J AM COLL CARDIOL, V25, P807, DOI 10.1016/0735-1097(94)00507-M
   Kaski JC, 1999, DEV CARDIOVASC MED, V213, P1
   Kaski JC, 2002, CARDIOVASC RES, V53, P620, DOI 10.1016/S0008-6363(01)00460-6
   KASKI JC, 1994, J AM COLL CARDIOL, V23, P652, DOI 10.1016/0735-1097(94)90750-1
   KASKI JC, 1995, AM J CARDIOL, V76, pD35
   Kayikcioglu M, 2003, EUR HEART J, V24, P1999, DOI 10.1016/S0195-668X(03)00478-0
   Kelly RF, 2003, CLIN CARDIOL, V26, P319, DOI 10.1002/clc.4950260705
   Manginas A, 1999, AM J CARDIOL, V83, P1562, DOI 10.1016/S0002-9149(99)00149-6
   MCGINN AL, 1990, CIRCULATION, V81, P1319, DOI 10.1161/01.CIR.81.4.1319
   Murakami H, 1998, J AM COLL CARDIOL, V32, P1287, DOI 10.1016/S0735-1097(98)00402-1
   QUYYUMI AA, 1992, CIRCULATION, V86, P1864, DOI 10.1161/01.CIR.86.6.1864
   Roqué M, 1998, J AM COLL CARDIOL, V31, P139, DOI 10.1016/S0735-1097(97)00436-1
   Sezgin AT, 2003, CORONARY ARTERY DIS, V14, P155, DOI 10.1097/00019501-200304000-00008
NR 27
TC 1
Z9 1
U1 0
U2 1
PU TAIWAN SOC GERIATRIC EMERGENCY & CRITICAL CARE MEDICINE-TSGECM
PI TAIPEI
PA 12F-14, NO 42, SEC 1, MINSHENG E RD, ZHONGSHAN DIST, TAIPEI, 104, TAIWAN
SN 1873-9598
EI 1873-958X
J9 INT J GERONTOL
JI Int. J. Gerontol.
PD SEP
PY 2008
VL 2
IS 3
BP 109
EP 114
DI 10.1016/S1873-9598(08)70047-4
PG 6
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 371PQ
UT WOS:000260843800005
DA 2025-06-11
ER

PT J
AU Averyanova, IV
AF Averyanova, I. V.
TI Association of 25(OH) Vitamin D with Cardiometabolic Risk Factors in the
   Age Aspect
SO BIOCHEMISTRY MOSCOW-SUPPLEMENT SERIES B-BIOMEDICAL CHEMISTRY
LA English
DT Article
DE young men; mature men; elderly men; cardiometabolic risk factors;
   vitamin D
ID HOMEOSTASIS MODEL ASSESSMENT; SERUM 25-HYDROXYVITAMIN D;
   INSULIN-RESISTANCE; D DEFICIENCY; PARATHYROID-HORMONE; GLUCOSE
AB Background: This study assessed the association of vitamin D status with the frequency of incidence of metabolic health risk factors, including obesity, hypo-alpha cholesterol, hypertriglyceridemia, carbohydrate metabolism disorders (hyperglycemia and insulin resistance), and cardiovascular system stress conditions in men of different ages. Aim: The research aimed at identifying cardiometabolic disorders in young, mature, and elderly men with suboptimal and optimal concentrations of 25(OH) vitamin D. Materials and methods: Two hundred and thirty-four Magadan oblast residents at early adulthood, maturity, and extreme old age participated in the survey. Each age group was divided into two samples: with optimal or suboptimal vitamin D level. We used photometric, immunochemiluminescent research methods, as well as standard methods for assessing body mass index and cardiovascular system. Results: The results showed rather high incidence of suboptimal 25(OH) vitamin D levels among the Magadan oblast population. Optimal vitamin D concentration was associated with a significant fall in the percentage of people with a hypertensive character of cardiovascular performance, with a lower incidence of hypoalphacholesterolemia, hyperglycemia, hypertriglyceridemia, and insulin resistance throughout all age groups, and was more common in elderly men. Conclusions: The suboptimal concentration of vitamin D can be considered as an additional nonstandard driving factor for age-associated cardiometabolic disorders. Metabolic healthcare needs preventive measures to level these disorders to contribute to active longevity and life expectancy.
C1 [Averyanova, I. V.] Russian Acad Sci, Arctic Sci Res Ctr, Far East Branch, Magadan 685000, Russia.
C3 Russian Academy of Sciences
RP Averyanova, IV (corresponding author), Russian Acad Sci, Arctic Sci Res Ctr, Far East Branch, Magadan 685000, Russia.
EM Inessa1382@mail.ru
RI Inessa, Averyanova/AAR-9371-2020
FU Arctic Scientific Research Center, Far East Branch, Russian Academy of
   Sciences [AAAA-A21-121010 69 0002-2]
FX The work was carried out with budget funding from the Arctic Scientific
   Research Center, Far East Branch, Russian Academy of Sciences within the
   framework of the topic Study of Intersystem and Intrasystem Reaction
   Mechanisms in the Formation of Functional Adaptive Reserves of the Human
   Body of the "Northern Type" at Different Stages of Ontogenesis of
   Persons Living in Uncomfortable and Extreme Conditions with the
   Determination of Integral Informative Health Indices (registration no.
   AAAA-A21-121010 69 0002-2).
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Bartelt A, 2014, NAT REV ENDOCRINOL, V10, P24, DOI 10.1038/nrendo.2013.204
   Bloomgarden Z.T., 2003, Care, V26, p933 939, DOI [10.2337/diacare.26.3.933, DOI 10.2337/DIACARE.26.3.933]
   Bouillon R, 2023, J STEROID BIOCHEM, V228, DOI 10.1016/j.jsbmb.2023.106248
   Bray GA, 2017, OBES REV, V18, P715, DOI 10.1111/obr.12551
   BURGESS ED, 1990, AM J HYPERTENS, V3, P903, DOI 10.1093/ajh/3.12.903
   Chen SC, 2015, J AM SOC HYPERTENS, V9, P885, DOI 10.1016/j.jash.2015.08.009
   Cho HJ, 2005, BIOL PHARM BULL, V28, P1418, DOI 10.1248/bpb.28.1418
   Christakos S, 2013, ANN NY ACAD SCI, V1287, P45, DOI 10.1111/nyas.12129
   Daryabor G, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.01582
   Di Cesare M, 2016, LANCET, V387, P1377, DOI 10.1016/s0140-6736(16)30054-x
   Fonseca MJ, 2012, NUTR J, V11, DOI 10.1186/1475-2891-11-64
   Forman JP, 2007, HYPERTENSION, V49, P1063, DOI 10.1161/HYPERTENSIONAHA.107.087288
   Gulseth HL, 2013, CURR VASC PHARMACOL, V11, P968, DOI 10.2174/15701611113119990169
   Holick MF, 2017, REV ENDOCR METAB DIS, V18, P153, DOI 10.1007/s11154-017-9424-1
   International Diabetes Federation, Worldwide Definition of the Metabolic Syndrome, DOI [10.1016/s1885-5857(06)60742-1, DOI 10.1016/S1885-5857(06)60742-1]
   Ju SY, 2014, J CLIN ENDOCR METAB, V99, P1053, DOI 10.1210/jc.2013-3577
   Juliaty A, 2021, CLIN NUTR ESPEN, V44, P200, DOI 10.1016/j.clnesp.2021.06.022
   Katsuki A, 2001, DIABETES CARE, V24, P362, DOI 10.2337/diacare.24.2.362
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kazi TG, 2009, BIOL TRACE ELEM RES, V127, P16, DOI 10.1007/s12011-008-8222-8
   Li LH, 2013, ENDOCRINE, V44, P465, DOI 10.1007/s12020-013-9885-2
   Lotta LA, 2015, DIABETES CARE, V38, P2177, DOI 10.2337/dc15-1218
   Lupton JR, 2016, J CLIN LIPIDOL, V10, P72, DOI 10.1016/j.jacl.2015.09.006
   Marcotorchino J, 2013, HORM MOL BIOL CLIN I, V15, P123, DOI 10.1515/hmbci-2013-0027
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McCarty MF, 2004, AM J CLIN NUTR, V80, P1451, DOI 10.1093/ajcn/80.5.1451
   Mosekilde L, 2005, CLIN ENDOCRINOL, V62, P265, DOI 10.1111/j.1365-2265.2005.02226.x
   Nikooyeh B., 2021, National Food and Nutrition Surveillance, V21, P1819, DOI [10.1186/s12889-021-11839-w, DOI 10.1186/S12889-021-11839-W]
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Peterson CA, 2014, THER ADV ENDOCRINOL, V5, P166, DOI 10.1177/2042018814547205
   Pigarova E. A., 2016, Problemy Endokrinologii, V62, P60, DOI 10.14341/probl201662460-84
   Roth CL, 2011, J OBES, V2011, DOI 10.1155/2011/495101
   Sabanayagam C, 2012, KIDNEY BLOOD PRESS R, V35, P106, DOI 10.1159/000330716
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sarkar C, 2022, HEALTH PLACE, V76, DOI 10.1016/j.healthplace.2022.102829
   Schulze MB, 2019, DIABETOLOGIA, V62, P558, DOI 10.1007/s00125-018-4787-8
   Sugden JA, 2008, DIABETIC MED, V25, P320, DOI 10.1111/j.1464-5491.2007.02360.x
   Velazquez-Roman J, 2021, J DIABETES COMPLICAT, V35, DOI 10.1016/j.jdiacomp.2021.108025
   Vimaleswaran KS, 2013, PLOS MED, V10, DOI 10.1371/journal.pmed.1001383
NR 41
TC 0
Z9 0
U1 0
U2 0
PU MAIK NAUKA-INTERPERIODICA
PI MOSCOW
PA PROFSOYUZNAYA UL 90, MOSCOW, 117997, RUSSIA
SN 1990-7508
EI 1990-7516
J9 BIOCHEM MOSC SUPPL B
JI Biochem. Mosc.-Suppl. Ser. B-Biomed. Chem.
PD JUN
PY 2024
VL 18
IS 2
BP 174
EP 184
DI 10.1134/S199075082360022X
PG 11
WC Biochemistry & Molecular Biology
WE Emerging Sources Citation Index (ESCI)
SC Biochemistry & Molecular Biology
GA D8Z8H
UT WOS:001299017400002
DA 2025-06-11
ER

PT J
AU Bataller-Sifre, R
   Guiral-Olivan, V
   Bataller-Alberola, L
AF Bataller-Sifre, Ramon
   Guiral-Olivan, Victoria
   Bataller-Alberola, Luis
TI New clinical and toxicological scenario of gammaglutamyltranspeptidase
SO REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
LA English
DT Article
DE Gammaglutamyltranspeptidase; Glutathione; Oxidative stress; Enzyme
   induction; Chronic hepatopathies; Diabetes mellitus; Environmental
   toxins; Cardiovascular risk
ID TRANSFERASE TRANSPEPTIDASE; SERUM
AB After the discovery of gammaglutamyltranspeptidase in 1950 by Hanes, the significance of its increased levels in clinical practice has mainly been focused on ethanol toxicity, and also some neoplasms and biliary tract obstruction.
   More recently, attention has swift to the metabolic functions of this enzyme, as a neutralizer of oxygen free radicals and as a glutathione donor to the cell. High serum levels of gamma-glutamyltranspeptidase is known to occur when oxidative stress is increased, or associated with several vascular risk factors and the insulin resistance syndrome, as an early marker of diabetes.
   There are also a number of drugs that induce the expression of the tissue enzyme (microsomes) with the result of high serum levels without structural damage to the liver. Because it is a ubiquitous enzyme, a very high number of causes can be involved, that may be difficult to recognize.
   Finally, because glutathione is necessary to conjugate a number of chemical compounds, from an epidemiological and toxicological perspective, the enzyme might be useful as a biomarker of several ambient toxins.
   In this review we want to emphasize the increasing clinical and diagnostic significance of this enzyme discovered half a century ago.
C1 [Bataller-Sifre, Ramon] Valencian Community, Valencia, Spain.
   [Guiral-Olivan, Victoria] Hosp Clin Univ, Dept Internal Med, Valencia, Spain.
   [Bataller-Alberola, Luis] Hosp Univ La Fe, Dept Neurol, Valencia, Spain.
C3 Hospital Universitari i Politecnic La Fe
RP Bataller-Sifre, R (corresponding author), C Gran Via Marques del Turia 52, Valencia 46005, Spain.
EM ramon.bataller@uv.es
CR Albertson TE, 2007, CLIN MANAGEMENT POIS, P755
   AMEER B, 1977, ANN INTERN MED, V87, P202, DOI 10.7326/0003-4819-87-2-202
   Balcells A, 1976, MED CLIN-BARCELONA, V66, P429
   BATALLERSIFRE R, 1979, REV ESP ENFERM APAR, V56, P327
   BUSACHI C, 1981, PATHOL RES PRACT, V172, P99, DOI 10.1016/S0344-0338(81)80126-4
   De Castro del Pozo S, 1973, Rev Clin Esp, V128, P317
   de la Pena Fernandez A, 1997, Rev Clin Esp, V197, P434
   Dechelette P, 1974, THESIS U LYON
   Elejalde Guerra J I, 2001, An Med Interna, V18, P1
   Ferenci P, 2000, CLIN SPECTRUM ALCOHO, P240
   Fujita M, 2000, EXP BIOL MOL, V235, P335
   Fusijama K, 1970, 4 M IASL ELS
   Gibinski K, 1966, Rev Int Hepatol, V16, P1249
   Gonzalez Buitrago TM, 1983, REV ESP REUMATOL, V10, P48
   HANES CS, 1950, NATURE, V166, P288, DOI 10.1038/166288a0
   HARDISON WGM, 1979, CLIN ENZYMOL, P199
   Hua-Yun S, 1986, CHINESE J INTERN MED, V25, P341
   IRELAND A, 1991, BRIT MED J, V302, P388, DOI 10.1136/bmj.302.6773.388
   IVANOV E, 1976, ENZYME, V21, P8, DOI 10.1159/000458837
   KASHYAP SK, 1986, TOXICOL LETT, V33, P107, DOI 10.1016/0378-4274(86)90075-5
   KOJIMA J, 1980, CLIN CHIM ACTA, V106, P165, DOI 10.1016/0009-8981(80)90169-2
   Kumar V., 1992, BASIC PATHOLOGY
   LAPERCHE Y, 1989, GASTROEN CLIN BIOL, V13, P783
   Lee DH, 2009, J EPIDEMIOL COMMUN H, V63, P884, DOI 10.1136/jech.2008.083592
   Lee DH, 2005, ATHEROSCLEROSIS, V178, P327, DOI 10.1016/j.atherosclerosis.2004.08.027
   Lee DH, 2003, DIABETOLOGIA, V46, P359, DOI 10.1007/s00125-003-1036-5
   Mac Sween RNM, 2002, PATHOLOGY LIVER, P96
   Mc Intyre N, 1992, HEPATOBILIARY DIS, P51
   Medina J, 2004, IMMUNOLOGY LIVER IMM, P47
   Paolicchi A, 2006, ATHEROSCLEROSIS, V186, P80, DOI 10.1016/j.atherosclerosis.2005.07.012
   Paolicchi A, 2005, J VIRAL HEPATITIS, V12, P269, DOI 10.1111/j.1365-2893.2005.00579.x
   PAUMGARTNER G, 1973, LIVER QUANTITATIVE A
   Renner EL, 1995, INVESTIGATIONS HEPAT, P664
   Reuter P, 2004, SPRINGER LEXIKON MED, P825
   Rodriguez Cuartero A, 1973, MED CLIN-BARCELONA, V61, P257
   Rodriguez-Cuartero A., 1973, REV CLIN ESP, V132, P21
   Rosalki S B, 1975, Adv Clin Chem, V17, P53, DOI 10.1016/S0065-2423(08)60248-6
   SHAW LM, 1978, EVALUATION LIVER FUN, P103
   Shimizu Y, 2010, STROKE, V41, P385, DOI 10.1161/STROKEAHA.109.569061
   Stolz AS, 1990, BIOCH TEST LIVER DIS, P658
   SZCZEKLIK E, 1961, GASTROENTEROLOGY, V41, P353
   TATE SS, 1981, MOL CELL BIOCHEM, V39, P357, DOI 10.1007/BF00232585
   Van der Reis L., 1976, ENXYMOLOGY LIVER
   Wilkinson JH, 1976, PRINCIPLES PRACTICE, P345
   Wilkinson JH, 1976, PRINCIPLES PRACTICE, P85
   Wise B L., 1985, Clinical Chemistry: Principles, Procedures, Correlations, P205
NR 46
TC 7
Z9 8
U1 0
U2 3
PU ARAN EDICIONES, S A
PI MADRID
PA CASTELLO, 128, 28006 MADRID, SPAIN
SN 1130-0108
EI 2340-4167
J9 REV ESP ENFERM DIG
JI Rev. Esp. Enferm. Dig.
PD NOV
PY 2011
VL 103
IS 11
BP 586
EP 589
DI 10.4321/S1130-01082011001100006
PG 4
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA V34GT
UT WOS:000209075600006
PM 22149561
OA gold
DA 2025-06-11
ER

PT J
AU Bagger, JP
   Thomassen, A
   Nielsen, TT
AF Bagger, JP
   Thomassen, A
   Nielsen, TT
TI Cardiac energy metabolism in patients with chest pain and normal
   coronary angiograms
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID ANGINA-PECTORIS; ARTERY DISEASE; MYOCARDIAL-METABOLISM; LACTATE
   PRODUCTION; PACING STRESS; SYNDROME-X; ARTERIOGRAMS; HEMODYNAMICS;
   ISCHEMIA; ALANINE
AB In 70 patients (94% were a consecutive series) with angina pectoris and normal coronary angiograms, we measured cardiac exchange of lactate, glucose, free fatty acids (FFAs), glutamate, alanine, citrate, and oxygen together with coronary sinus blood flow and blood pressure in response to pacing (150 beats/min). Twelve patients had an abnormal exercise stress test; 26 developed ST depression and 46 had chest pain in response to pacing. Sixteen patients had no ST changes (exercise/pacing) and no pain during pacing. Pacing induced an increase in cardiac carbohydrate extraction and a decrease in FFA extraction in the entire group of patients. Less than 3% of patients had significant cardiac lactate release in response to pacing, and there were no consistent differences in the cardiac metabolic or hemodynamic responses between patient groups. The pacing-induced shift from FFA to carbohydrate extraction probably reflects the cardiac response to an acute workload. A definite sign of cardiac ischemia (lactate production) was a rare finding in these patients and not confined to the demonstration of electrocardiographic signs of ischemia. (C)2000 by Excerpta Medico, Inc.
C1 Univ London Imperial Coll Sci Technol & Med, Sch Med, Hammersmith Hosp, Cardiothorac Directorate, London W12 0NN, England.
   Skejby Univ Hosp, Dept Cardiol, Aarhus, Denmark.
C3 Imperial College London; Aarhus University
RP Bagger, JP (corresponding author), Univ London Imperial Coll Sci Technol & Med, Sch Med, Hammersmith Hosp, Cardiothorac Directorate, Du Cane Rd, London W12 0NN, England.
CR ARBOGAST R, 1973, AM J CARDIOL, V32, P257, DOI 10.1016/S0002-9149(73)80130-4
   BAGGER J P, 1990, Pharmacology and Toxicology Supplement, V66, P1
   BAGGER JP, 1985, CARDIOVASC RES, V19, P27, DOI 10.1093/cvr/19.1.27
   BEMILLER CR, 1973, CIRCULATION, V47, P36, DOI 10.1161/01.CIR.47.1.36
   BERLAND J, 1984, CLIN CARDIOL, V7, P485, DOI 10.1002/clc.4960070904
   Botker HE, 1997, AM J CARDIOL, V79, P1615, DOI 10.1016/S0002-9149(97)00209-9
   BOUDOULAS H, 1974, AM J CARDIOL, V34, P501, DOI 10.1016/0002-9149(74)90118-0
   CAMICI P, 1989, AM J PHYSIOL, V257, pE309, DOI 10.1152/ajpendo.1989.257.3.E309
   CAMICI PG, 1991, J AM COLL CARDIOL, V17, P1461, DOI 10.1016/0735-1097(91)90632-J
   CANNON RO, 1988, AM J CARDIOL, V61, P1338, DOI 10.1016/0002-9149(88)91180-0
   FERRANNINI E, 1988, METABOLISM, V37, P287, DOI 10.1016/0026-0495(88)90110-2
   GREENBERG MA, 1987, J AM COLL CARDIOL, V9, P743, DOI 10.1016/S0735-1097(87)80227-9
   KEMP HG, 1973, AM J MED, V54, P735, DOI 10.1016/0002-9343(73)90060-0
   MAMMOHANSINGH P, 1975, AM HEART J, V90, P555, DOI 10.1016/0002-8703(75)90217-3
   MOST AS, 1972, CIRCULATION, V45, P92, DOI 10.1161/01.CIR.45.1.92
   OPHERK D, 1981, CIRCULATION, V63, P817, DOI 10.1161/01.CIR.63.4.817
   OPIE LH, 1991, HEART PHYSL METABOLI, P208
   PAPANICOLAOU MN, 1986, AM J CARDIOL, V58, P1181, DOI 10.1016/0002-9149(86)90378-4
   RANDLE PJ, 1979, HDB PHYSL          2, V1, P805
   Richter EA., 1996, HDB PHYSL SECTION 12, P912, DOI 10.1002/cphy.cp120120
   Rosano GMC, 1996, EUR HEART J, V17, P1175
   SAFER B, 1975, CIRC RES, V37, P527, DOI 10.1161/01.RES.37.5.527
   TAEGTMEYER H, 1977, J BIOL CHEM, V252, P5010
   THOMASSEN A, 1988, AM J CARDIOL, V62, P686, DOI 10.1016/0002-9149(88)91203-9
   THOMASSEN AR, 1983, CLIN SCI, V64, P33, DOI 10.1042/cs0640033
NR 25
TC 9
Z9 9
U1 0
U2 0
PU EXCERPTA MEDICA INC
PI NEW YORK
PA 245 WEST 17TH STREET, NEW YORK, NY 10011 USA
SN 0002-9149
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD FEB 1
PY 2000
VL 85
IS 3
BP 315
EP 320
DI 10.1016/S0002-9149(99)00739-0
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 278KW
UT WOS:000084989800007
PM 11078299
DA 2025-06-11
ER

PT J
AU Chen, C
   Zhao, CY
   Jin, HY
   Jiang, ZP
   Wang, W
   Li, WY
AF Chen, Chen
   Zhao, Chenyu
   Jin, Hongyu
   Jiang, Zhiping
   Wang, Wei
   Li, Wen-Yang
TI Association of composite dietary antioxidant index with circadian
   syndrome: evidence from NHANES
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE composite dietary antioxidant index; dietary antioxidant; circadian
   syndrome; cross-sectional study; NHANES; restricted cubic spline
ID OXIDATIVE STRESS; METABOLIC SYNDROME; VITAMIN-A; SERUM ZINC; MEN;
   HOMEOSTASIS; EXERCISE; RHYTHM; ROS
AB Background The Circadian Syndrome (CircS) has been linked to various chronic diseases. However, the relationship between composite dietary antioxidant index (CDAI) and CircS has remained unexplored. This study aimed to investigate the potential association between CDAI and CircS.Methods Cross-sectional analyses were based on the National Health and Nutrition Examination Survey (NHANES) 2005-2018. Dietary consumption was assessed via the 24-h diet recall method and CDAI was computed following a validated approach involving six antioxidants. CircS was defined based on metabolic syndrome components, supplemented by short sleep duration and depressive symptoms. The relationship between CDAI and CircS was examined using weighted multivariable logistic regression and subgroup analyses. Additionally, restricted cubic spline (RCS) regression was employed to investigate potential nonlinear correlations.Results Among 11,048 subjects included (mean age 47.57 years), 2,733 (weighted prevalence = 22.13%) were reported to have CircS. Logistic regression revealed that the highest quartile of CDAI was inversely associated with the risk of CircS {odds ratio (OR) [95% CI = 0.69 (0.55-0.87)]} and the risk of depression [OR = 0.59 (0.48-0.72)], short sleep duration [OR = 0.54 (0.41-0.70)], elevated fasting glucose [OR = 0.80 (0.65-0.98)], elevated triglycerides (TG) [OR = 0.74 (0.59-0.92)], elevated waist circumference [OR = 0.65, (0.52-0.80)] and reduced high-density lipoprotein cholesterol (HDL-C) [OR = 0.75 (0.61-0.92)], respectively. A dose-response gradient in odds of CircS components was noted as CDAI levels increased, particularly with depression and short sleep duration. RCS showed a non-linear relationship between CDAI and CircS, with a U-shaped correlation found between Zinc and CircS (inflection point 12.63). Subgroup analysis showed BMI modified the inverse association between CDAI and CircS (p for interaction = 0.003).Conclusion This study revealed a non-linear and negative association between CDAI and CircS risk, with a U-shaped correlation observed between Zinc and CircS. Obese individuals might not benefit from excessively high CDAI. The results suggest that a higher CDAI score was correlated with a decreased risk of CircS.
C1 [Chen, Chen; Jin, Hongyu; Jiang, Zhiping; Wang, Wei; Li, Wen-Yang] China Med Univ, Resp & Crit Care Dept, Hosp 1, Shenyang, Peoples R China.
   [Zhao, Chenyu] China Med Univ, Dept China Med Univ, Queens Univ Belfast Joint Coll, Sch Pharm, Shenyang, Peoples R China.
C3 China Medical University; China Medical University
RP Li, WY (corresponding author), China Med Univ, Resp & Crit Care Dept, Hosp 1, Shenyang, Peoples R China.
EM 20122043@cmu.edu.cn
RI Zhao, Chenyu/MSZ-4264-2025; JIANG, Zhiping/ABB-8497-2021; li,
   wenyang/LVR-1826-2024
OI Chen, Chen/0009-0008-0510-1085; Zhao, Chenyu/0009-0007-9490-2062
FU National Natural Science Foundation of China [82370093]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This work was
   supported by the National Natural Science Foundation of China (no.
   82370093).
CR Akbar Z, 2024, NUTRIENTS, V16, DOI 10.3390/nu16111581
   Akbar Z, 2023, NUTRIENTS, V15, DOI 10.3390/nu15153396
   Beydoun MA, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0103490
   Beyer TA, 2008, CELL CYCLE, V7, P874, DOI 10.4161/cc.7.7.5617
   Blaner WS, 2021, ANNU REV NUTR, V41, P105, DOI 10.1146/annurev-nutr-082018-124228
   Cao RY, 2024, J CLIN PERIODONTOL, V51, P702, DOI 10.1111/jcpe.13960
   Conaway HH, 2013, ENDOCR REV, V34, P766, DOI 10.1210/er.2012-1071
   Deng MG, 2023, NUTR J, V22, DOI 10.1186/s12937-023-00898-x
   Depner CM, 2014, CURR DIABETES REP, V14, DOI 10.1007/s11892-014-0507-z
   Feng CQ, 2024, BMC PUBLIC HEALTH, V24, DOI 10.1186/s12889-024-17649-0
   Forman HJ, 2021, NAT REV DRUG DISCOV, V20, P689, DOI 10.1038/s41573-021-00233-1
   Franco C, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms232214489
   García-Arroyo FE, 2019, FREE RADICAL BIO MED, V141, P182, DOI 10.1016/j.freeradbiomed.2019.06.016
   Guo XR, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.886244
   Gyöngyösi N, 2014, ANTIOXID REDOX SIGN, V20, P3007, DOI 10.1089/ars.2013.5558
   He HQ, 2024, AGING-US, V16, P15, DOI 10.18632/aging.205232
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Huang WY, 2011, J CLIN INVEST, V121, P2133, DOI 10.1172/JCI46043
   Johnson Clifford L, 2013, Vital Health Stat 2, P1
   Kasai M, 2012, BIOL TRACE ELEM RES, V150, P285, DOI 10.1007/s12011-012-9472-z
   Kawamoto N, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-16087-x
   Kazmierczak-Baranska J, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051501
   Kim HN, 2016, NUTRITION, V32, P332, DOI 10.1016/j.nut.2015.09.006
   Kim SA, 2019, NUTR J, V18, DOI 10.1186/s12937-019-0459-x
   Lee KH, 2012, MOL MED REP, V5, P299, DOI 10.3892/mmr.2011.651
   Liao ZY, 2024, EUR REV MED PHARMACO, V28, P1513, DOI 10.26355/eurrev_202402_35481
   Fanjul-Moles ML, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/7420637
   Matsui H, 2010, TOXICOLOGY, V276, P27, DOI 10.1016/j.tox.2010.06.011
   Maugeri A, 2019, FREE RADICAL BIO MED, V131, P274, DOI 10.1016/j.freeradbiomed.2018.12.018
   McNamara P, 2001, CELL, V105, P877, DOI 10.1016/S0092-8674(01)00401-9
   Megha KB, 2024, MOL NEUROBIOL, V61, P5541, DOI 10.1007/s12035-024-03915-0
   Merry TL, 2020, AM J PHYSIOL-CELL PH, V318, pC337, DOI 10.1152/ajpcell.00426.2019
   Fonzo LSN, 2009, HIPPOCAMPUS, V19, P869, DOI 10.1002/hipo.20571
   Övermöhle C, 2023, NUTRIENTS, V15, DOI 10.3390/nu15204460
   Panda S, 2019, NAT REV ENDOCRINOL, V15, P67, DOI 10.1038/s41574-018-0142-x
   Pérez-Torres I, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22041786
   Pingitore A, 2015, NUTRITION, V31, P916, DOI 10.1016/j.nut.2015.02.005
   Puchau B, 2010, NUTRITION, V26, P534, DOI 10.1016/j.nut.2009.06.017
   Sajadimajd S, 2018, CURR CANCER DRUG TAR, V18, P538, DOI 10.2174/1568009617666171002144228
   Shearer KD, 2012, TRENDS NEUROSCI, V35, P733, DOI 10.1016/j.tins.2012.08.005
   Shi Z, 2021, J INTERN MED, V289, P851, DOI 10.1111/joim.13204
   Shi ZM, 2024, DIABETES-METAB RES, V40, DOI 10.1002/dmrr.3827
   Shi ZM, 2022, NUTRIENTS, V14, DOI 10.3390/nu14245317
   Shirai H, 2006, BIOCHEM BIOPH RES CO, V351, P387, DOI 10.1016/j.bbrc.2006.10.031
   Sies H, 2015, REDOX BIOL, V4, P180, DOI 10.1016/j.redox.2015.01.002
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Taneja SK, 2012, J TRACE ELEM MED BIO, V26, P267, DOI 10.1016/j.jtemb.2012.03.002
   Terao J, 2023, FOOD FUNCT, V14, P7799, DOI [10.1039/d3fo02330c, 10.1039/D3FO02330C]
   Wahl S, 2019, J BIOPHOTONICS, V12, DOI 10.1002/jbio.201900102
   Wang MM, 2021, REPROD DOMEST ANIM, V56, P1066, DOI 10.1111/rda.13950
   Wang M, 2023, FOOD FUNCT, V14, P9279, DOI [10.1039/D3FO01157G, 10.1039/d3fo01157g]
   Wang XH, 2019, AM J CLIN NUTR, V110, P76, DOI 10.1093/ajcn/nqz041
   Wang YL, 2022, FRONT NEUROL, V13, DOI 10.3389/fneur.2022.946172
   Wang Y, 2018, NUTRIENTS, V10, DOI 10.3390/nu10050572
   Wilking M, 2013, ANTIOXID REDOX SIGN, V19, P192, DOI 10.1089/ars.2012.4889
   Wu MY, 2023, CLIN EXP HYPERTENS, V45, DOI 10.1080/10641963.2023.2233712
   Wu YY, 2024, BIOL TRACE ELEM RES, V202, P3051, DOI 10.1007/s12011-023-03918-3
   Wu Y, 2024, CLIN INTERV AGING, V19, P163, DOI 10.2147/CIA.S448354
   Xie L, 2024, FRONT ENDOCRINOL, V15, DOI 10.3389/fendo.2024.1431223
   Xiong BQ, 2024, BMC PUBLIC HEALTH, V24, DOI 10.1186/s12889-024-18047-2
   Yary T, 2017, NUTRITION, V37, P43, DOI 10.1016/j.nut.2016.09.004
   Yu YC, 2022, INT J CANCER, V150, P1599, DOI 10.1002/ijc.33925
   Yu YH, 2012, NUTR RES, V32, P71, DOI 10.1016/j.nutres.2011.12.004
   Yuan Y, 2014, NEUROL SCI, V35, P923, DOI 10.1007/s10072-014-1668-x
   Zhao LY, 2022, FRONT PUBLIC HEALTH, V10, DOI 10.3389/fpubh.2022.988727
   Zhu ZY, 2024, FRONT NUTR, V11, DOI 10.3389/fnut.2024.1373709
   Zimmet P, 2019, J INTERN MED, V286, P181, DOI 10.1111/joim.12924
   Zipf George, 2013, Vital Health Stat 1, P1
   Zorov DB, 2014, PHYSIOL REV, V94, P909, DOI 10.1152/physrev.00026.2013
NR 69
TC 0
Z9 0
U1 2
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JAN 3
PY 2025
VL 11
AR 1501352
DI 10.3389/fnut.2024.1501352
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA S4D0P
UT WOS:001397736800001
PM 39830063
OA gold
DA 2025-06-11
ER

PT J
AU Çelik, ÖM
   Koçak, T
   Köksal, E
AF Celik, Ozge Mengi
   Kocak, Tevfik
   Koksal, Eda
TI Effects of Diurnal Ramadan Intermittent Fasting on Cardiometabolic Risk
   Factors and Sleep Quality in Healthy Turkish Adults
SO ECOLOGY OF FOOD AND NUTRITION
LA English
DT Article
DE Blood glucose; lipid profile; inflammatory cytokines; sleep quality;
   Ramadan fasting
ID BIOCHEMICAL PARAMETERS; HEMATOLOGICAL PARAMETERS; OXIDATIVE STRESS;
   BODY-WEIGHT; GLUCOSE; MARKERS
AB This study aimed to evaluate the effect of diurnal Ramadan fasting on cardiometabolic risk factors (blood glucose, lipid profile, inflammatory cytokines) and sleep quality in healthy Turkish adults. This prospective observational study was conducted with a total of 32 individuals (12 males, 20 females) who were aged between 19-32 years and fasted for 25 or more continuous days in Ankara, Turkey between 1 Ramadan 1442 and 30 Ramadan 1442. Individuals applied fasting for 16 hours in the spring season. Blood samples were taken after at least 8 hours of fasting, anthropometric measurements were taken and sleep quality was assessed using The Pittsburgh Sleep Quality Index (PSQI) at the beginning and the end of Ramadan. There was a significant decrease in body mass index (BMI), C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-alpha) levels during Ramadan fasting (p < .005). There were no changes in lipid profiles and sleep quality. There was a significant increase in fasting blood glucose levels (p < .05); however, this change is within normal limits. There was also a significant relationship between BMI and CRP, IL-6, and TNF-alpha levels (p < .05). The diurnal Ramadan fasting did not affect lipid profiles and sleep quality in healthy Turkish subjects. However, decreased BMI and inflammatory cytokine levels were observed at the end of Ramadan fasting. More studies are needed to clarify the role of Ramadan fasting in healthy populations.
C1 [Celik, Ozge Mengi] Trakya Univ, Fac Hlth Sci, Dept Nutr & Dietet, Edirne, Turkey.
   [Kocak, Tevfik; Koksal, Eda] Gazi Univ, Fac Hlth Sci, Dept Nutr & Dietet, Emek Biskek Cad 6 Sok Gazi Univ 2, TR-06490 Ankara, Cankaya, Turkey.
C3 Trakya University; Gazi University; Presidency Turkey
RP Koçak, T (corresponding author), Gazi Univ, Fac Hlth Sci, Dept Nutr & Dietet, Emek Biskek Cad 6 Sok Gazi Univ 2, TR-06490 Ankara, Cankaya, Turkey.
EM dyt_tevfik@hotmail.com
RI MENGİ ÇELİK, ÖZGE/AAU-7320-2020; Koksal, Eda/AAW-2900-2021; KOCAK,
   TEVFIK/GNP-0559-2022
OI KOCAK, TEVFIK/0000-0002-4096-6796; Mengi Celik,
   Ozge/0000-0002-0298-9591; KOKSAL, EDA/0000-0002-7930-9910
CR Agargun M.Y., 1996, T RK PSIKIYATRI DERG, V7, P107
   Aksungar FB, 2007, ANN NUTR METAB, V51, P88, DOI 10.1159/000100954
   Al-barha NS, 2018, AM J MENS HEALTH, V13, DOI 10.1177/1557988318816925
   ALHADER AFA, 1994, ANN SAUDI MED, V14, P139, DOI 10.5144/0256-4947.1994.139
   Alsubheen SA, 2017, BRIT J NUTR, V118, P1023, DOI 10.1017/S0007114517003221
   Asemi Z, 2015, ARCH IRAN MED, V18, P806, DOI 0151812/AIM.003
   BaHammam AS, 2020, FRONT NUTR, V7, DOI 10.3389/fnut.2020.00028
   BaHammam AS, 2014, J SLEEP RES, V23, P35, DOI 10.1111/jsr.12076
   Boukhris O, 2019, SPORTS, V7, DOI 10.3390/sports7050118
   Buysse D J, 1989, Psychiatry Res, V28, P193
   Dewanti L, 2006, EUR J CLIN NUTR, V60, P877, DOI 10.1038/sj.ejcn.1602393
   Faris M. A. I. E., 2019, Journal of Nutrition & Intermediary Metabolism, V15, P18, DOI 10.1016/j.jnim.2018.11.005
   Faris MAE, 2020, SLEEP BREATH, V24, P771, DOI 10.1007/s11325-019-01986-1
   Faris MAIE, 2019, DIABETES RES CLIN PR, V153, P166, DOI 10.1016/j.diabres.2019.05.023
   Faris MAIE, 2020, BRIT J NUTR, V123, P1, DOI 10.1017/S000711451900254X
   Fernando HA, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020478
   Gnanou JV, 2015, J DIABETES METAB DIS, V14, DOI 10.1186/s40200-015-0183-9
   Harvie MN, 2011, INT J OBESITY, V35, P714, DOI 10.1038/ijo.2010.171
   Herrera CP, 2012, J SPORT SCI, V30, pS85, DOI 10.1080/02640414.2012.676666
   Hosseini SRA, 2013, IRAN J BASIC MED SCI, V16, P845
   Ibrahim WH, 2008, ANN NUTR METAB, V53, P175, DOI 10.1159/000172979
   Jahrami HA, 2021, NUTR METAB CARDIOVAS, V31, P2273, DOI 10.1016/j.numecd.2021.05.002
   Jahrami HA, 2020, EUR J NUTR, V59, P2291, DOI 10.1007/s00394-020-02216-1
   Khan N, 2017, E MEDITERR HEALTH J, V23, P274, DOI 10.26719/2017.23.4.274
   Kiyani MM, 2017, J RELIG HEALTH, V56, P55, DOI 10.1007/s10943-015-0084-8
   Kul S, 2014, J RELIG HEALTH, V53, P929, DOI 10.1007/s10943-013-9687-0
   Lessan N, 2018, AM J CLIN NUTR, V107, P54, DOI 10.1093/ajcn/nqx016
   Longo VD, 2014, CELL METAB, V19, P181, DOI 10.1016/j.cmet.2013.12.008
   Mirzaei B, 2012, IRAN J BASIC MED SCI, V15, P1215
   Moro T, 2016, J TRANSL MED, V14, DOI 10.1186/s12967-016-1044-0
   Nachvak SM, 2019, EUR J CLIN NUTR, V73, P594, DOI 10.1038/s41430-018-0189-8
   Ongsara S, 2017, J CLIN DIAGN RES, V11, pBC14, DOI 10.7860/JCDR/2017/27294.10634
   Paoli A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11040719
   Patterson RE, 2017, ANNU REV NUTR, V37, P371, DOI 10.1146/annurev-nutr-071816-064634
   Qujeq D, 2002, ANN SAUDI MED, V22, P297, DOI 10.5144/0256-4947.2002.297
   Rahbar AR, 2019, INT J PREVENTIVE MED, V10, DOI 10.4103/ijpvm.IJPVM_252_17
   Rezaie P, 2016, J RES MED SCI, V21
   Salahuddin M, 2014, J CLIN DIAGN RES, V8, P16, DOI 10.7860/JCDR/2014/8108.4092
   Samad Fatima, 2015, J Ayub Med Coll Abbottabad, V27, P338
   Sarraf-Zadegan N, 2000, ANN SAUDI MED, V20, P377, DOI 10.5144/0256-4947.2000.377
   Ünalacak M, 2011, METAB SYNDR RELAT D, V9, P157, DOI 10.1089/met.2010.0084
   Vardarli MC, 2014, TURK J MED SCI, V44, P1010, DOI 10.3906/sag-1308-30
   Winter TA, 2006, CURR OPIN CLIN NUTR, V9, P596, DOI 10.1097/01.mco.0000241670.24923.5b
   Yeoh ECK, 2015, ANN ACAD MED SINGAP, V44, P202
NR 44
TC 6
Z9 6
U1 0
U2 8
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0367-0244
EI 1543-5237
J9 ECOL FOOD NUTR
JI Ecol. Food Nutr.
PD SEP 3
PY 2022
VL 61
IS 5
BP 595
EP 607
DI 10.1080/03670244.2022.2089878
EA JUN 2022
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 4I6NQ
UT WOS:000814633700001
PM 35730413
DA 2025-06-11
ER

PT J
AU Lehnen, AM
   Leguisamo, NM
   Dias, LD
   Pinto, GH
   Okamoto, NM
   Machado, UF
   Schaan, BD
AF Lehnen, A. M.
   Leguisamo, N. M.
   Dias, L. D.
   Pinto, G. H.
   Okamoto, N. M.
   Machado, U. F.
   Schaan, B. D.
TI Changes in Renal Glucose Transporters in an Animal Model of Metabolic
   Syndrome
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE metabolic syndrome; glucose transporters; SHR; monosodium glutamate
ID DIABETIC-RATS; INSULIN-RESISTANCE; OXIDATIVE STRESS; RESPONSE ELEMENT;
   GENE-EXPRESSION; GLUT2 GENE; OBESITY; KIDNEY; IDENTIFICATION; SODIUM
AB Considering the similarity between structural, hemodynamic, and functional changes of obesity-related renal disease and diabetic nephropathy, we hypothesized that renal glucose transporter changes occur in obesity as in diabetes. The aim of the work was to evaluate GLUT1 and GLUT2 in kidneys of an animal model of metabolic syndrome. Neonate spontaneously hypertensive rats (SHR), n=15/group, were treated with monosodium glutamate (5 mg/g) (MetS) for 9 days and compared with saline-treated Wistar-Kyoto (C) and SHR (H) rats. Lee index, systolic arterial pressure (SAP), glycemia, insulin resistance, triglycerides, and HDL cholesterol were evaluated at 3 and 6 months. Medullar GLUT1 and cortical GLUT2 were analyzed by Western blot. MetS vs. C and H rats had the highest Lee index (p<0.001) and insulin resistance (3-months C: 4.3 +/- 0.7, H: 3.9 +/- 0.9, MetS: 2.7 +/- 0.6; 6-months C: 4.2 +/- 0.6, H: 3.8 +/- 0.5, MetS: 2.4 +/- 0.6% min(-1), p<0.001), similar glycemia, and the lowest HDL-cholesterol at 6-months (p<0.001). In the MetS and H rats, SAP was higher vs. C at 3-months (p<0.001) and 6-months (C: 151 +/- 15, H: 190 +/- 11, MetS: 185 +/- 13 mm Hg, p<0.001) of age. GLUT1 was ? 13x lower (p<0.001) at 3-months, reestablishing its content at 6-months in MetS group, while GLUT2 was 2x higher (p<0.001) in this group at 6-months of age. Renal GLUT1 and GLUT2 are modulated in kidney of rats with metabolic syndrome, where obesity, insulin resistance and hypertension coexist, despite normoglycemia. Like in diabetes, cortical GLUT2 overexpression may contribute to the development of kidney disease.
C1 [Lehnen, A. M.; Schaan, B. D.] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Serv Endocrinol, BR-90046900 Porto Alegre, RS, Brazil.
   [Okamoto, N. M.; Machado, U. F.] Univ Sao Paulo, Inst Ciencias Biomed, Dept Fisiol & Biofis, BR-05508 Sao Paulo, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Hospital de Clinicas de Porto
   Alegre; Universidade de Sao Paulo
RP Lehnen, AM (corresponding author), Inst Cardiol Rio Grande Do Sul, Av Princesa Isabel 395 Santana, BR-90620001 Porto Alegre, RS, Brazil.
EM amlehnen@terra.com.br
RI Lehnen, Alexandre/Q-3459-2016; Machado, Ubiratan/F-3096-2017; Schaan,
   Beatriz/I-7518-2017
OI Leguisamo, Natalia/0000-0002-1869-9329; Schaan,
   Beatriz/0000-0002-2128-8387
CR Bae JH, 2001, ATHEROSCLEROSIS, V155, P517, DOI 10.1016/S0021-9150(00)00601-8
   BERNARDIS LL, 1968, J ENDOCRINOL, V40, P527, DOI 10.1677/joe.0.0400527
   Chagnac A, 2008, NEPHROL DIAL TRANSPL, V23, P3946, DOI 10.1093/ndt/gfn379
   Mattos AMD, 2012, NEUROSCI LETT, V522, P118, DOI 10.1016/j.neulet.2012.06.021
   Freitas HS, 2009, MOL CELL ENDOCRINOL, V305, P63, DOI 10.1016/j.mce.2009.02.014
   Freitas HS, 2007, NEPHRON PHYSIOL, V105, P42, DOI 10.1159/000098442
   Goumenos DS, 2009, NEPHROL DIAL TRANSPL, V24, P3732, DOI 10.1093/ndt/gfp329
   Hunley Tracy E, 2010, Curr Opin Nephrol Hypertens, V19, P227, DOI 10.1097/MNH.0b013e3283374c09
   Im SS, 2005, DIABETES, V54, P1684, DOI 10.2337/diabetes.54.6.1684
   Jordan SD, 2011, NAT CELL BIOL, V13, P434, DOI 10.1038/ncb2211
   Kotur-Stevuljevic J, 2013, PEDIATR NEPHROL, V28, P295, DOI 10.1007/s00467-012-2323-5
   Leguisamo NM, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-100
   Lehnen AM, 2013, AUTON NEUROSCI-BASIC, V176, P64, DOI 10.1016/j.autneu.2013.02.011
   Li YJ, 2001, CHINESE MED J-PEKING, V114, P824
   Marks J, 2003, J PHYSIOL-LONDON, V553, P137, DOI 10.1113/jphysiol.2003.046268
   Mori RCT, 2008, DIABETES OBES METAB, V10, P596, DOI 10.1111/j.1463-1326.2008.00870.x
   Munkhaugen J, 2009, AM J KIDNEY DIS, V54, P638, DOI 10.1053/j.ajkd.2009.03.023
   Nguyen MTA, 2005, J BIOL CHEM, V280, P35361, DOI 10.1074/jbc.M504611200
   Papa PD, 2002, LIFE SCI, V71, P1917
   Rencurel F, 1996, BIOCHEM J, V314, P903, DOI 10.1042/bj3140903
   Schaan BD, 2005, AUTON NEUROSCI-BASIC, V117, P54, DOI 10.1016/j.autneu.2004.11.001
   Schaan BD, 2001, HORM METAB RES, V33, P664, DOI 10.1055/s-2001-18683
   Schaan Beatriz D'Agord, 2005, Nephron Physiology, V100, P43
   Seraphim PM, 2007, MOL CELL ENDOCRINOL, V276, P80, DOI 10.1016/j.mce.2007.07.004
   Serra A, 2008, KIDNEY INT, V73, P947, DOI 10.1038/sj.ki.5002796
   Trakooljul N, 2010, ANIM GENET, V41, P357, DOI 10.1111/j.1365-2052.2009.02015.x
   Vestri S, 2001, J MEMBRANE BIOL, V182, P105, DOI 10.1007/s00232-001-0036-y
   Vivante A, 2012, ARCH INTERN MED, P1, DOI 10.1001/2013.jamainternmed.85
   Vulin AI, 2004, J BIOL CHEM, V279, P25172, DOI 10.1074/jbc.M403184200
   Zhang Jing, 2001, Chinese Medical Sciences Journal, V16, P35
NR 30
TC 4
Z9 6
U1 0
U2 8
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD OCT
PY 2013
VL 45
IS 11
BP 840
EP 843
DI 10.1055/s-0033-1354381
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 234ZV
UT WOS:000325684600011
PM 24062089
DA 2025-06-11
ER

PT J
AU Kök Kendirlioglu, B
   Yüksel Öksüz, Ö
   Kalelioglu, T
   Sözen, S
   Ünalan Özperçin, P
   Cihnioglu, R
   Karamustafalioglu, N
AF Kok Kendirlioglu, Burcu
   Yuksel Oksuz, Ozge
   Kalelioglu, Tevfik
   Sozen, Sule
   Unalan Ozpercin, Pelin
   Cihnioglu, Refik
   Karamustafalioglu, Nesrin
TI The Role of Resolvin D1 in Indicating Chronic Inflammation and Axonal
   Damage in Bipolar Disorder: A Comparative Study of Manic and Depressive
   Episodes
SO NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
LA English
DT Article
DE Axonal degeneration; bipolar disorder; metabolic syndrome;
   neuroinflammation; resolvin D1
ID DOCOSAHEXAENOIC ACID; FATTY-ACIDS; DEFICITS; D2; RESPONSES; STRESS
AB Introduction: Bipolar disorder (BD) is a chronic disorder associated with significant psychiatric morbidity and disability. Recent research has linked inflammatory processes to the pathology of BD. Resolvin D1 (RvD1), an anti-inflammatory molecule derived from eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been shown to inhibit apoptosis and neuroinflammation, and promote neurogenesis. This study aims to determine changes in serum RvD1 levels between acute episode and euthymic periods in patients with BD and their association with inflammatory and metabolic syndrome (MetS) parameters. Methods: This prospective clinical study was conducted with patients diagnosed with BD-I according to SCID-5. Patients whose serum RvD1 levels were assessed during manic and depressive episodes in the previous study were invited to return to the study after at least 8 weeks, when they had reached the euthymic period. Blood samples for RvD1, C-reactive protein (CRP), and hemogram tests were collected during both acute episodes and remission periods. Results: The study included 32 patients in manic episodes, 27 in depressive episodes, and 41 healthy controls, with no significant age difference amongthe groups. RvD1 levels decreased significantly from manic episodes to complete remission period (p=0.017, z=-2.391) during follow-up. The decrease from depression to remission was not statistically significant. Serum RvD1 levels in patients with depressive episodes in remission remained high in the control group (p=0.581, z=-0.553). During the followup period, white blood cell (p=0.009, z=-2.606) and neutrophil (p=0.007, z=-2.693) in mania period and CRP values in depression period (p=0.004, z=-2.880) were found to have decreased statistically. Conclusions: The study indicates that serum RvD1 levels are elevated during manic and depressive episodes in BD patients compared to healthy controls and decrease significantly during the remission period in patients with manic episode. We propose the potential utility of RvD1 as a diagnostic marker for identifying manic and depressive states. We can assume that there is an inflammatory process in BD in which RvD1 also plays a role. Further research is needed to explore the therapeutic potential of targeting RvD1 pathways in BD treatment.
C1 [Kok Kendirlioglu, Burcu] Maltepe Univ, Fac Med, Dept Psychiat, Istanbul, Turkiye.
   [Yuksel Oksuz, Ozge] Erenkoy Mental Hlth Res & Training Hosp, Dept Psychiat, Istanbul, Turkiye.
   [Kalelioglu, Tevfik] Univ Virginia, Sch Med, Dept Psychiat, Charlottesville, VA USA.
   [Sozen, Sule] Balikli Rum Hosp, Dept Psychiat, Istanbul, Turkiye.
   [Unalan Ozpercin, Pelin] Iskenderun State Hosp, Dept Psychiat, Hatay, Turkiye.
   [Cihnioglu, Refik] Istinye Univ Liv Hosp, Dept Psychiat, Istanbul, Turkiye.
   [Karamustafalioglu, Nesrin] Bakirkoy Mental Hlth Res & Training Hosp, Dept Psychiat, Istanbul, Turkiye.
C3 Maltepe University; Erenkoy Mental & Neurological Disorders Education &
   Research Hospital; University of Virginia; Hatay Iskenderun State
   Hospital; Ankara Liv Hospital; Istinye University; Istanbul Bakirkoy
   Mental Health & Neurology Training & Research Hospital
RP Kök Kendirlioglu, B (corresponding author), Maltepe Univ, Fac Med, Dept Psychiat, Istanbul, Turkiye.
EM kokburcu@gmail.com
RI Kök Kendirlioğlu, Burcu/ABB-1983-2021
CR Abdallah ZY, 2021, J CHILD SCI, V11, pe163, DOI 10.1055/s-0041-1731303
   Babic D, 2010, PSYCHIAT DANUB, V22, P75
   Clària J, 2012, J IMMUNOL, V189, P2597, DOI 10.4049/jimmunol.1201272
   Das UN, 2013, PROG NEURO-PSYCHOPH, V42, P122, DOI 10.1016/j.pnpbp.2012.06.010
   Deyama S, 2025, NEUROSCI RES, V211, P85, DOI 10.1016/j.neures.2022.10.006
   Deyama S, 2017, INT J NEUROPSYCHOPH, V20, P575, DOI 10.1093/ijnp/pyx023
   Drew PD, 2000, J NEUROIMMUNOL, V111, P77, DOI 10.1016/S0165-5728(00)00386-6
   Ferat-Osorio E, 2024, WORLD J PSYCHIATR, V14, DOI 10.5498/wjp.v14.i3.342
   Furuyashiki T, 2019, INT IMMUNOL, V31, P579, DOI 10.1093/intimm/dxz023
   Guo JM, 2024, BMC PSYCHIATRY, V24, DOI 10.1186/s12888-024-05724-0
   Ho CFY, 2018, NEUROCHEM RES, V43, P1587, DOI 10.1007/s11064-018-2573-0
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Ishikawa Y, 2017, BEHAV BRAIN RES, V332, P233, DOI 10.1016/j.bbr.2017.06.010
   Kasak M, 2022, J MOL NEUROSCI, V72, P1313, DOI 10.1007/s12031-022-02000-2
   Keiko K, 2018, J AFFECT DISORDERS, V241, P200, DOI 10.1016/j.jad.2018.08.006
   Kendirlioglu BC, 2021, South Clin Istanb Eurasia, V32, P273
   Kendirlioglu BK, 2020, NORD J PSYCHIAT, V74, P83, DOI 10.1080/08039488.2019.1673480
   Khan MZ, 2017, NEUROPHARMACOLOGY, V113, P639, DOI 10.1016/j.neuropharm.2015.05.013
   Kok Kendirlioglu Burcu, 2023, Psychiatr Danub, V35, P210, DOI 10.24869/psyd.2023.210
   Korkmaz SA, 2023, J AFFECT DISORDERS, V339, P426, DOI 10.1016/j.jad.2023.07.079
   Krashia P, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-11928-w
   Laan M, 1999, THORAX, V54, P911, DOI 10.1136/thx.54.10.911
   Lamon-Fava S, 2023, NEUROPSYCHOPHARMACOL, V48, P929, DOI 10.1038/s41386-022-01527-7
   Leao FF, 2022, N-S ARCH PHARMACOL, V395, P1269, DOI 10.1007/s00210-022-02274-8
   Li C, 2019, J CLIN PSYCHIAT, V80, DOI 10.4088/JCP.18m12422
   McElroy SL, 2012, CURR PSYCHIAT REP, V14, P650, DOI 10.1007/s11920-012-0313-8
   McIntyre RS, 2020, LANCET, V396, P1841, DOI 10.1016/S0140-6736(20)31544-0
   McNamara RK, 2008, PSYCHIAT RES, V160, P285, DOI 10.1016/j.psychres.2007.08.021
   McNamara RK, 2015, PSYCHIAT RES, V230, P447, DOI 10.1016/j.psychres.2015.09.035
   Meinhard N, 2014, NORD J PSYCHIAT, V68, P81, DOI 10.3109/08039488.2013.775341
   Morris T, 2010, P NATL ACAD SCI USA, V107, P8842, DOI 10.1073/pnas.1000373107
   Poletti S, 2024, TRANSL PSYCHIAT, V14, DOI 10.1038/s41398-024-02921-z
   Pomponi M, 2014, INDIAN J MED RES, V139, P1
   Prüss H, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055859
   Rasgon N, 2003, BIPOLAR DISORD, V5, P48, DOI 10.1034/j.1399-5618.2003.00010.x
   Shao L, 2016, BIPOLAR DISORD, V18, P342, DOI 10.1111/bdi.12395
   Uyanik V, 2015, PSYCHIAT RES, V228, P386, DOI 10.1016/j.psychres.2015.05.078
   Wang L, 2014, CHINESE MED J-PEKING, V127, P803, DOI 10.3760/cma.j.issn.0366-6999.20131044
   Xu F, 2023, Front Psychiatry, V14
   Young AH, 2021, CURR TOP BEHAV NEURO, V48, P1, DOI 10.1007/7854_2020_179
   Yu DF, 2023, NEUROPSYCH DIS TREAT, V19, P1463, DOI 10.2147/NDT.S417630
   Zhang Y, 2023, PROG NEURO-PSYCHOPH, V125, DOI 10.1016/j.pnpbp.2023.110740
NR 42
TC 0
Z9 0
U1 3
U2 3
PU  TURKISH NEUROPSYCHIATRY ASSOC-TURK NOROPSIKIYATRI  DERNEGI
PI ISTANBUL
PA MESRUTIYET MAH HALASKARGAZI CAD SITE APT NO 128-1 SISLI, ISTANBUL,
   Turkiye
SN 1300-0667
EI 1309-4866
J9 NOROPSIKIYATRI ARS
JI Noropsikiyatri Ars.
PD MAR
PY 2025
VL 62
IS 1
BP 3
EP 10
DI 10.29399/npa.28891
PG 8
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA Z1R1T
UT WOS:001436755800002
PM 40046207
DA 2025-06-11
ER

PT J
AU Sugiyama, F
   Kobayashi, N
   Ishikawa, M
   Onoda, S
   Ishimitsu, T
AF Sugiyama, Fumihiro
   Kobayashi, Naohiko
   Ishikawa, Mayuko
   Onoda, Sho
   Ishimitsu, Toshihiko
TI Renoprotective mechanisms of telmisartan on renal injury and
   inflammation in SHRSP.Z-Lepr<SUP>fa</SUP>/IzmDmcr rats
SO CLINICAL AND EXPERIMENTAL NEPHROLOGY
LA English
DT Article
DE Telmisartan; Metabolic syndrome; Nephrosclerosis
ID SENSITIVE HYPERTENSIVE-RATS; TYPE-2 DIABETIC-RATS; RHO-KINASE INHIBITOR;
   ANGIOTENSIN-II; METABOLIC SYNDROME; RECEPTOR BLOCKADE; PODOCYTE INJURY;
   CARDIAC-PERFORMANCE; CELL-PROLIFERATION; OXIDATIVE STRESS
AB SHRSP.Z-Lepr(fa)/IzmDmcr (SHRSP fatty) rats create a new animal model of metabolic syndrome. However, the renoprotective effect of telmisartan therapy and its underlying mechanisms in SHRSP fatty rats remain unknown. We evaluate the effects of long-term telmisartan therapy on renal dysfunction, podocyte injury, inflammation, and transforming growth factor-beta 1 (TGF-beta 1)/Smad, epithelial-mesenchymal transition (EMT), mitogen-activated protein kinase (MAPK), Rho-kinase, and cell-cycle progression pathway in the renal cortex of SHRSP fatty rats.
   Seven-week-old male SHRSP fatty rats were treated with vehicle, telmisartan, and hydralazine for 8 weeks. Age-matched male Wistar-Kyoto/Izumo rats served as a control group.
   Vehicle-treated SHRSP fatty rats developed proteinuria and renal dysfunction, which in the telmisartan group was less than the vehicle and hydralazine group without changing blood pressure. Glomerulosclerosis and interstitial fibrosis were impaired in SHRSP fatty rats, and the renal damage in the telmisartan group was less than the vehicle and hydralazine groups. Decreased expression of nephrin and podocin and increased desmin-positive area in SHRSP fatty rats were restored by telmisartan but not hydralazine. TGF-beta 1/Smad, EMT marker, MAPK, Rho-kinase, and cell-cycle progression pathways were upregulated in SHRSP fatty rats, and these increased proteins in the telmisartan group were less than the vehicle and hydralazine group. Telmisartan administration resulted in significant suppression in tumor necrosis factor-alpha expression and nuclear factor-kappa B phosphorylation.
   Long-term telmisartan therapy may improve renal dysfunction, glomerulosclerosis, podocyte injury, and inflammation associated with EMT, TGF-beta/Smad, MAPK, Rho-kinase pathway in SHRSP fatty rats. Thus, telmisartan may have significant therapeutic potential for metabolic syndrome.
C1 [Sugiyama, Fumihiro; Kobayashi, Naohiko; Ishikawa, Mayuko; Onoda, Sho; Ishimitsu, Toshihiko] Dokkyo Med Univ, Sch Med, Dept Cardiol & Nephrol, Mibu, Tochigi 3210293, Japan.
C3 Dokkyo Medical University
RP Kobayashi, N (corresponding author), Dokkyo Med Univ, Sch Med, Dept Cardiol & Nephrol, Mibu, Tochigi 3210293, Japan.
EM nao-koba@dokkyomed.ac.jp
CR Benson SC, 2008, J HYPERTENS, V26, P973, DOI 10.1097/HJH.0b013e3282f56ba5
   Böttinger EP, 2002, J AM SOC NEPHROL, V13, P2600, DOI 10.1097/01.ASN.0000033611.79556.AE
   BRANDT RR, 1993, J AM COLL CARDIOL, V22, pA86, DOI 10.1016/0735-1097(93)90468-G
   Du N, 2012, ONCOL REP, V27, P1893, DOI 10.3892/or.2012.1720
   Han HJ, 2007, J CELL PHYSIOL, V211, P618, DOI 10.1002/jcp.20967
   Hayashida T, 2003, FASEB J, V17, P1576, DOI 10.1096/fj.03-0037fje
   Hiraoka-Yamamoto J, 2004, CLIN EXP PHARMACOL P, V31, P107, DOI 10.1111/j.1440-1681.2004.04121.x
   Kagota S, 2010, CLIN EXP PHARMACOL P, V37, P1035, DOI 10.1111/j.1440-1681.2010.05432.x
   Kitagawa M, 1996, EMBO J, V15, P7060, DOI 10.1002/j.1460-2075.1996.tb01097.x
   Kobayashi N, 2006, HYPERTENSION, V47, P671, DOI 10.1161/01.HYP.0000203148.42892.7a
   Kobayashi N, 2005, HYPERTENSION, V45, P538, DOI 10.1161/01.HYP.0000157408.43807.5a
   Kobayashi N, 2008, AM J HYPERTENS, V21, P576, DOI 10.1038/ajh.2008.27
   Kobayashi N, 2009, AM J HYPERTENS, V22, P176, DOI 10.1038/ajh.2008.333
   Lehmann K, 2000, GENE DEV, V14, P2610, DOI 10.1101/gad.181700
   Liu YH, 2006, KIDNEY INT, V69, P213, DOI 10.1038/sj.ki.5000054
   MORGAN DO, 1995, NATURE, V374, P131, DOI 10.1038/374131a0
   Mulay SR, 2010, CHEM-BIOL INTERACT, V185, P137, DOI 10.1016/j.cbi.2010.03.008
   Nishikimi T, 2009, REGUL PEPTIDES, V154, P44, DOI 10.1016/j.regpep.2009.02.006
   Nishiyama A, 2008, J HYPERTENS, V26, P1849, DOI 10.1097/HJH.0b013e3283060efa
   Nishiyama A, 2010, J PHARMACOL EXP THER, V332, P1072, DOI 10.1124/jpet.109.158113
   Ren ZL, 2012, CELL SIGNAL, V24, P443, DOI 10.1016/j.cellsig.2011.09.022
   Rhyu DY, 2005, J AM SOC NEPHROL, V16, P667, DOI 10.1681/ASN.2004050425
   Shi YG, 2003, CELL, V113, P685, DOI 10.1016/S0092-8674(03)00432-X
   Takai S, 2005, HYPERTENS RES, V28, P593, DOI 10.1291/hypres.28.593
   Takeda Y, 2010, HYPERTENS RES, V33, P965, DOI 10.1038/hr.2010.112
   Takeshima H, 2012, J ATHEROSCLER THROMB, V19, P326, DOI 10.5551/jat.11114
   Ueno T, 2008, HYPERTENS RES, V31, P1021, DOI 10.1291/hypres.31.1021
   Valcourt U, 2005, MOL BIOL CELL, V16, P1987, DOI 10.1091/mbc.e04-08-0658
   Villa L, 2011, NEPHROL DIAL TRANSPL, V26, P3131, DOI 10.1093/ndt/gfr096
   Wolf G, 2005, DIABETES, V54, P1626, DOI 10.2337/diabetes.54.6.1626
   Xu ZG, 2005, CIRCULATION, V111, P1962, DOI 10.1161/01.CIR.0000161831.07637.63
   Yadav A, 2010, AM J PHYSIOL-RENAL, V298, pF734, DOI 10.1152/ajprenal.00415.2009
   Yoshida K, 2007, J HYPERTENS, V25, P1633, DOI 10.1097/HJH.0b013e32814db89f
NR 33
TC 11
Z9 14
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1342-1751
EI 1437-7799
J9 CLIN EXP NEPHROL
JI Clin. Exp. Nephrol.
PD AUG
PY 2013
VL 17
IS 4
BP 515
EP 524
DI 10.1007/s10157-012-0759-3
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 206HW
UT WOS:000323511000006
PM 23268284
DA 2025-06-11
ER

PT J
AU Nishida, H
   Sohara, E
   Nomura, N
   Chiga, M
   Alessi, DR
   Rai, T
   Sasaki, S
   Uchida, S
AF Nishida, Hidenori
   Sohara, Eisei
   Nomura, Naohiro
   Chiga, Motoko
   Alessi, Dario R.
   Rai, Tatemitsu
   Sasaki, Sei
   Uchida, Shinichi
TI Phosphatidylinositol 3-Kinase/Akt Signaling Pathway Activates the
   WNK-OSR1/SPAK-NCC Phosphorylation Cascade in Hyperinsulinemic db/db Mice
SO HYPERTENSION
LA English
DT Article
DE WNK; PI3K; Akt; NaCl cotransporter; insulin; obesity; sodium; dependent
   hypertension
ID NA+-CL-COTRANSPORTER; BLOOD-PRESSURE; INSULIN SENSITIVITY; METABOLIC
   SYNDROME; DIETARY SALT; KINASE-B; IN-VIVO; SODIUM; HYPERTENSION;
   INHIBITOR
AB Metabolic syndrome patients have insulin resistance, which causes hyperinsulinemia, which in turn causes aberrant increased renal sodium reabsorption. The precise mechanisms underlying this greater salt sensitivity of hyperinsulinemic patients remain unclear. Abnormal activation of the recently identified with-no-lysine kinase (WNK)-oxidative stress-responsive kinase 1 (OSR1)/STE20/SPS1-related proline/alanine-rich kinase (SPAK)-NaCl cotransporter (NCC) phosphorylation cascade results in the salt-sensitive hypertension of pseudohypoaldosteronism type II. Here, we report a study of renal WNK-OSR1/SPAK-NCC cascade activation in the db/db mouse model of hyperinsulinemic metabolic syndrome. Thiazide sensitivity was increased, suggesting greater activity of NCC in db/db mice. In fact, increased phosphorylation of OSR1/SPAK and NCC was observed. In both Spak(T243A/+) and Osr1(T185A/+) knock-in db/db mice, which carry mutations that disrupt the signal from WNK kinases, increased phosphorylation of NCC and elevated blood pressure were completely corrected, indicating that phosphorylation of SPAK and OSR1 by WNK kinases is required for the increased activation and phosphorylation of NCC in this model. Renal phosphorylated Akt was increased in db/db mice, suggesting that increased NCC phosphorylation is regulated by the phosphatidylinositol 3-kinase/Akt signaling cascade in the kidney in response to hyperinsulinemia. A phosphatidylinositol 3-kinase inhibitor (NVP-BEZ235) corrected the increased OSR1/SPAK-NCC phosphorylation. Another more specific phosphatidylinositol 3-kinase inhibitor (GDC-0941) and an Akt inhibitor (MK-2206) also inhibited increased NCC phosphorylation. These results indicate that the phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in db/db mice. This mechanism may play a role in the pathogenesis of salt-sensitive hypertension in human hyperinsulinemic conditions, such as the metabolic syndrome. (Hypertension. 2012; 60: 981-990.). Online Data Supplement
C1 [Sohara, Eisei] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Nephrol, Bunkyo Ku, Tokyo 1138519, Japan.
   [Alessi, Dario R.] Univ Dundee, Coll Life Sci, Med Res Council, Prot Phosphorylat Unit, Dundee, Scotland.
C3 Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU);
   University of Dundee
RP Sohara, E (corresponding author), Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Nephrol, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138519, Japan.
EM esohara.kid@tmd.ac.jp
RI Rai, Tatemitsu/K-7165-2019; Alessi, Dario/JFS-5796-2023
OI Nomura, Naohiro/0000-0002-6998-1922; Alessi, Dario/0000-0002-2140-9185
FU Ministry of Education, Culture, Sports, Science, and Technology of
   Japan; Japan Society for the Promotion of Science; Salt Science Research
   Foundation [1228]; Takeda Science Foundation; Kanae Foundation for the
   Promotion of Medical Science; Nakajima Foundation; Grants-in-Aid for
   Scientific Research [24790836, 22390168, 22249032] Funding Source:
   KAKEN; MRC [MC_U127070193] Funding Source: UKRI
FX This study was supported in part by Grants-in-Aid for Scientific
   Research on Priority Areas from the Ministry of Education, Culture,
   Sports, Science, and Technology of Japan; Grants-in-Aid for Scientific
   Research on Creative Scientific Research from the Japan Society for the
   Promotion of Science; Grant-in-Aid for Scientific Research (A) from the
   Japan Society for the Promotion of Science; Grant-in-Aid for Young
   Scientists (B) from the Ministry of Education, Culture, Sports, Science,
   and Technology of Japan; the Salt Science Research Foundation (1228);
   Takeda Science Foundation; Kanae Foundation for the Promotion of Medical
   Science; and the Nakajima Foundation.
CR Achard JM, 2001, CLIN EXP PHARMACOL P, V28, P1048, DOI 10.1046/j.1440-1681.2001.03575.x
   Alessi DR, 1998, BBA-MOL CELL BIOL L, V1436, P151, DOI 10.1016/S0005-2760(98)00133-7
   Alessi DR, 1996, EMBO J, V15, P6541, DOI 10.1002/j.1460-2075.1996.tb01045.x
   Catena C, 2003, KIDNEY INT, V64, P2163, DOI 10.1046/j.1523-1755.2003.00313.x
   Chakraborty A, 2010, CELL, V143, P897, DOI 10.1016/j.cell.2010.11.032
   Chen H, 1996, CELL, V84, P491, DOI 10.1016/S0092-8674(00)81294-5
   CHEN J, 2009, J GERONTOL B-PSYCHOL, V373, P829, DOI DOI 10.1016/S0140-6736(09)60144-6
   Chiga M, 2008, KIDNEY INT, V74, P1403, DOI 10.1038/ki.2008.451
   Chin M, 2005, AM J PATHOL, V166, P1629, DOI 10.1016/S0002-9440(10)62473-X
   Cho DC, 2010, CLIN CANCER RES, V16, P3628, DOI 10.1158/1078-0432.CCR-09-3022
   DEFRONZO RA, 1976, J CLIN INVEST, V58, P83, DOI 10.1172/JCI108463
   DEFRONZO RA, 1975, J CLIN INVEST, V55, P845, DOI 10.1172/JCI107996
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Faber AC, 2009, P NATL ACAD SCI USA, V106, P19503, DOI 10.1073/pnas.0905056106
   Feliers D, 2001, KIDNEY INT, V60, P495, DOI 10.1046/j.1523-1755.2001.060002495.x
   Galletti F, 1997, J HYPERTENS, V15, P1485, DOI 10.1097/00004872-199715120-00017
   García-Martínez JM, 2011, BRIT J CANCER, V104, P1116, DOI 10.1038/bjc.2011.83
   GORDON RD, 1986, HYPERTENSION, V8, P93, DOI 10.1161/01.HYP.8.2.93
   Hirai H, 2010, MOL CANCER THER, V9, P1956, DOI 10.1158/1535-7163.MCT-09-1012
   Hirata K, 2009, BIOCHEM BIOPH RES CO, V380, P44, DOI 10.1016/j.bbrc.2009.01.003
   Komers R, 2012, CLIN SCI, V123, P635, DOI 10.1042/CS20120003
   Kraatz BP, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012838
   Kuroda S, 1999, J HUM HYPERTENS, V13, P257, DOI 10.1038/sj.jhh.1000800
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lawlor MA, 2001, J CELL SCI, V114, P2903
   Maira SM, 2008, MOL CANCER THER, V7, P1851, DOI 10.1158/1535-7163.MCT-08-0017
   Naito S, 2011, CLIN EXP NEPHROL, V15, P195, DOI 10.1007/s10157-010-0378-9
   Rafiqi FH, 2010, EMBO MOL MED, V2, P63, DOI 10.1002/emmm.200900058
   Raynaud FI, 2009, MOL CANCER THER, V8, P1725, DOI 10.1158/1535-7163.MCT-08-1200
   Ring AM, 2007, P NATL ACAD SCI USA, V104, P4025, DOI 10.1073/pnas.0611728104
   Rozansky DJ, 2009, J CLIN INVEST, V119, P2601, DOI 10.1172/JCI38323
   Rutkai I, 2009, CARDIOVASC RES, V83, P148, DOI 10.1093/cvr/cvp098
   San-Cristobal P, 2009, P NATL ACAD SCI USA, V106, P4384, DOI 10.1073/pnas.0813238106
   Sandberg MB, 2007, AM J PHYSIOL-RENAL, V293, pF662, DOI 10.1152/ajprenal.00064.2007
   SCHAMBELAN M, 1981, KIDNEY INT, V19, P716, DOI 10.1038/ki.1981.72
   Schnyder B, 2002, AM J PHYSIOL-ENDOC M, V282, pE87, DOI 10.1152/ajpendo.00050.2001
   Sechi LA, 1996, HYPERTENSION, V27, P955, DOI 10.1161/01.HYP.27.4.955
   Senador D, 2009, EXP PHYSIOL, V94, P648, DOI 10.1113/expphysiol.2008.046474
   Shao J, 2000, J ENDOCRINOL, V167, P107, DOI 10.1677/joe.0.1670107
   Shibuya K, 2005, DIABETES, V54, P838, DOI 10.2337/diabetes.54.3.838
   SHIMAMOTO K, 1994, HYPERTENSION, V23, pI29, DOI 10.1161/01.HYP.23.1_Suppl.I29
   Smith GC, 2012, BIOCHEM J, V442, P161, DOI 10.1042/BJ20111913
   Sohara E, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024277
   Song J, 2006, AM J PHYSIOL-RENAL, V290, pF1055, DOI 10.1152/ajprenal.00108.2005
   Talati G, 2010, BIOCHEM BIOPH RES CO, V393, P844, DOI 10.1016/j.bbrc.2010.02.096
   Tiwari S, 2007, AM J PHYSIOL-RENAL, V293, pF178, DOI 10.1152/ajprenal.00447.2006
   Vallon V, 2009, AM J PHYSIOL-RENAL, V297, pF704, DOI 10.1152/ajprenal.00030.2009
   Vitari AC, 2004, BIOCHEM J, V378, P257, DOI 10.1042/BJ20031692
   Wang RH, 2011, J CLIN INVEST, V121, P4477, DOI 10.1172/JCI46243
   Weinberger MH, 2001, HYPERTENSION, V37, P429, DOI 10.1161/01.HYP.37.2.429
   Wilson FH, 2001, SCIENCE, V293, P1107, DOI 10.1126/science.1062844
   Yang SS, 2007, CELL METAB, V5, P331, DOI 10.1016/j.cmet.2007.03.009
   Zdychová J, 2005, PHYSIOL RES, V54, P1, DOI 10.33549/physiolres.930582
NR 53
TC 78
Z9 82
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD OCT
PY 2012
VL 60
IS 4
BP 981
EP +
DI 10.1161/HYPERTENSIONAHA.112.201509
PG 22
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 006IF
UT WOS:000308812000022
PM 22949526
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Dwivedi, AK
   Jang, D
   Belkin, O
   Aickareth, J
   Renteria, M
   Hawwar, M
   Croft, J
   Kalas, MA
   Zuckerman, M
   Zhang, J
AF Dwivedi, Alok K.
   Jang, David
   Belkin, Ofek
   Aickareth, Justin
   Renteria, Mellisa
   Hawwar, Majd
   Croft, Jacob
   Kalas, M. Ammar
   Zuckerman, Marc
   Zhang, Jun
TI Metabolic Syndrome and Hemorrhagic Stroke in Hispanic Elderly Patients
   with Cerebral Cavernous Malformations
SO DIAGNOSTICS
LA English
DT Article
DE cerebral cavernous malformations (CCMs); metabolic syndrome; risk
   factors; hemorrhagic stroke; Mexican Hispanics
ID CARDIOVASCULAR RISK; OXIDATIVE STRESS; DISEASE SEVERITY; PATHOGENESIS;
   INFLAMMATION; HYPERTENSION; ASSOCIATION; PREVALENCE; HISTORY; IMPACT
AB Background/Objectives: Cerebral cavernous malformations (CCMs) are neurological disorders that increase the risk of hemorrhagic stroke. The Mexican Hispanic population has a higher prevalence of both CCMs and metabolic syndrome (MetS), defined by the presence of three or more of the following: central obesity, elevated triglycerides, low HDL, dyslipidemia, hypertension, or elevated fasting glucose. MetS is also associated with an increased risk of hemorrhagic stroke. However, the connection between MetS and hemorrhagic stroke in Hispanic CCM patients remains uncertain. Additionally, it is unclear if Hispanic CCM patients have different cardiometabolic profiles compared to controls. Methods: We analyzed a retrospective cohort of Mexican Hispanic adult CCM patients, including age- and gender-matched controls from the NHANES database. Fisher's exact test or an unpaired Student's t-test was used to compare risk factors between the CCM cohort and controls. Additionally, we conducted relative risk regression analysis to assess the adjusted association of MetS with hemorrhagic stroke. Results: The CCM cohort showed higher rates of epilepsy (24.6% vs. 1.6%, p < 0.001) and hemorrhagic stroke (36.6% vs. 3.6%, p < 0.001), but a lower prevalence of MetS (14% vs. 54.8%, p < 0.001) compared to age- and gender-matched Mexican Hispanic controls. The adjusted analysis revealed that among CCM patients in the older age group (age >= 50 years), MetS was associated with hemorrhagic stroke (RR = 2.38, 95%CI: 1.40-4.02, p = 0.001). Conclusions: This study reveals distinct features of CCMs in the Mexican Hispanic population, indicating a higher risk of hemorrhagic stroke and epilepsy compared to other ethnic groups. To mitigate the risk of hemorrhagic stroke, controlling blood pressure and managing comorbidities like metabolic syndrome (MetS) and epilepsy are essential, particularly in CCM patients aged 50 years and above.
C1 [Dwivedi, Alok K.; Jang, David; Belkin, Ofek; Aickareth, Justin; Renteria, Mellisa; Hawwar, Majd; Croft, Jacob; Zhang, Jun] Texas Tech Univ Hlth Sci Ctr, Dept Mol, El Paso, TX 79905 USA.
   [Dwivedi, Alok K.; Jang, David; Belkin, Ofek; Aickareth, Justin; Renteria, Mellisa; Hawwar, Majd; Croft, Jacob; Zhang, Jun] Texas Tech Univ Hlth Sci Ctr, Dept Translat Med, El Paso, TX 79905 USA.
   [Kalas, M. Ammar; Zuckerman, Marc] Texas Tech Univ Hlth Sci Ctr, Dept Internal Med, El Paso, TX 79905 USA.
C3 Texas Tech University System; Texas Tech University Health Sciences
   Center El Paso; Texas Tech University System; Texas Tech University
   Health Sciences Center El Paso; Texas Tech University System; Texas Tech
   University Health Sciences Center El Paso
RP Zhang, J (corresponding author), Texas Tech Univ Hlth Sci Ctr, Dept Mol, El Paso, TX 79905 USA.; Zhang, J (corresponding author), Texas Tech Univ Hlth Sci Ctr, Dept Translat Med, El Paso, TX 79905 USA.
EM alok.dwivedi@ttuhsc.edu; jun.zhang2000@gmail.com
RI Zhang, Jun/G-9091-2017; Croft, Jacob/JDD-7285-2023
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Antognelli C, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9020124
   Batra S, 2009, NAT REV NEUROL, V5, P659, DOI 10.1038/nrneurol.2009.177
   Brinjikji W, 2017, CHILD NERV SYST, V33, P1539, DOI 10.1007/s00381-017-3484-0
   Chei CL, 2008, HYPERTENS RES, V31, P1887, DOI 10.1291/hypres.31.1887
   Chen BX, 2021, STROKE, V52, P1259, DOI 10.1161/STROKEAHA.120.031569
   Chen YC, 2014, J HUM HYPERTENS, V28, P689, DOI 10.1038/jhh.2013.152
   Choquet H, 2016, FREE RADICAL BIO MED, V92, P100, DOI 10.1016/j.freeradbiomed.2016.01.008
   Choquet H, 2014, CEREBROVASC DIS, V37, P57, DOI 10.1159/000356839
   Dubey P, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2022.33088
   Dwivedi AK, 2022, J INVEST MED, V70, P1759, DOI 10.1136/jim-2022-002479
   Dwivedi AK, 2020, CANCER REP-US, V3, DOI 10.1002/cnr2.1211
   Dwivedi AK, 2014, J APPL STAT, V41, P484, DOI 10.1080/02664763.2013.840772
   Galovic M, 2021, DRUG AGING, V38, P285, DOI 10.1007/s40266-021-00837-7
   Hertz RP, 2006, AM J PREV MED, V30, P103, DOI 10.1016/j.amepre.2005.10.015
   Hu G, 2005, STROKE, V36, P2538, DOI 10.1161/01.STR.0000190894.30964.75
   Idiculla PS, 2020, EUR NEUROL, V83, P360, DOI 10.1159/000508748
   Kong L, 2022, NEUROSURG REV, V45, P2961, DOI 10.1007/s10143-022-01815-2
   Larvie M, 2015, AM J NEURORADIOL, V36, P475, DOI 10.3174/ajnr.A4172
   Lazor JW, 2019, ACAD RADIOL, V26, P443, DOI 10.1016/j.acra.2018.05.021
   Mastrocola R, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms231911151
   Mohamed AT, 2023, EGYPT J NEUROL PSYCH, V59, DOI 10.1186/s41983-022-00603-5
   Mooneyand MA, 2017, HAND CLINIC, V143, P279, DOI 10.1016/B978-0-444-63640-9.00026-6
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Osborn MF, 2014, J STROKE CEREBROVASC, V23, P1477, DOI 10.1016/j.jstrokecerebrovasdis.2013.12.017
   Padarti Akhil, 2018, Vessel Plus, V2, DOI 10.20517/2574-1209.2018.34
   Perrelli A, 2021, FREE RADICAL BIO MED, V172, P403, DOI 10.1016/j.freeradbiomed.2021.06.021
   Petersen TA, 2010, AM J NEURORADIOL, V31, P377, DOI 10.3174/ajnr.A1822
   Peyre M, 2021, NEW ENGL J MED, V385, P996, DOI 10.1056/NEJMoa2100440
   Retta SF, 2016, INT J BIOCHEM CELL B, V81, P254, DOI 10.1016/j.biocel.2016.09.011
   RIGAMONTI D, 1988, ACTA NEUROCHIR, V92, P100, DOI 10.1007/BF01401979
   Takahashi T, 2014, ACUTE MED SURG, V1, P17, DOI 10.1002/ams2.1
   Tang AT, 2017, NATURE, V545, P305, DOI 10.1038/nature22075
   Timerman D, 2016, CUREUS J MED SCIENCE, V8, DOI 10.7759/cureus.799
   Trimble B, 2008, NEUROL CLIN, V26, P1177, DOI 10.1016/j.ncl.2008.05.010
   Zhang J, 2001, AM J HUM GENET, V69, P178
   Zhang J, 2000, GENOMICS, V70, P392, DOI 10.1006/geno.2000.6410
   Zhang J, 2022, J NEUROL NEUROSUR PS, V93, P808, DOI 10.1136/jnnp-2022-328901
NR 38
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-4418
J9 DIAGNOSTICS
JI Diagnostics
PD APR 30
PY 2025
VL 15
IS 9
AR 1144
DI 10.3390/diagnostics15091144
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 2NN1F
UT WOS:001486863700001
PM 40361966
DA 2025-06-11
ER

PT J
AU Park, S
   Ham, JO
   Lee, BK
AF Park, Sunmin
   Ham, Jung-O.
   Lee, Byung-Kook
TI Effects of total vitamin A, vitamin C, and fruit intake on risk for
   metabolic syndrome in Korean women and men
SO NUTRITION
LA English
DT Article
DE Vitamin C intake; Vitamin A intake; Antioxidants; Metabolic syndrome;
   Sex
ID NUTRITION EXAMINATION SURVEY; OXIDATIVE STRESS; SERUM CAROTENOIDS;
   NATIONAL-HEALTH; PREVALENCE; ASSOCIATION; ANTIOXIDANTS; POPULATION;
   VEGETABLES; COMPONENTS
AB Objectives: The question of whether the consumption of antioxidants prevents and alleviates metabolic syndrome (MetS) by reducing insulin resistance remains controversial. The aim of this study was to assess whether the intake of vitamin A (including beta-carotene), vitamin C, fruits, or vegetables was negatively associated with MetS in Korean adults aged >= 20 y.
   Methods: We conducted a cross-sectional study of 27,656 adults >= 20 y of age who participated in the 2007-2012 Korean National Health and Nutrition Examination Survey. Daily intake of vitamin A and vitamin C was assessed by 24-h recall, and the consumption of fruits and vegetables was determined using a food frequency questionnaire. Odds ratios (ORs) for MetS were calculated for log(2)-transformed vitamin A and C intake values and for the interaction of sex with vitamin A and C intake, after covariate adjustment.
   Results: Interactions were seen between total vitamin A and C intake and sex for MetS. With a twofold increase in total vitamin A and C intake in women, the ORs (95% confidence intervals) for metabolic syndrome were 0.942 (0.901-0.985) and 0.933 (0.883-0.987), indicating decreases of 5.8% and 6.7% in MetS, respectively. There were no equivalent decreases in men. Women in the second and highest tertiles of fruit intake exhibited 17.5% and 21.8% lower incidences of MetS, respectively, compared with women in the lowest tertile.
   Conclusions: The intake of total vitamin A and C, as well as moderate and high fruit intake, may have alleviated MetS in women, but not in men, in a representative sample of the general South Korean population. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Park, Sunmin] Hoseo Univ, Dept Food & Nutr, Asan, Chungnam Do, South Korea.
   [Ham, Jung-O.] Soonchunhyang Univ Hosp, Dept Occupat & Environm Med, Cheonan, South Korea.
   [Lee, Byung-Kook] Korea Ind Hlth Assoc, Seoul, South Korea.
C3 Hoseo University; Soonchunhyang University; Soonchunhyang University
   Hospital
RP Lee, BK (corresponding author), Korea Ind Hlth Assoc, Seoul, South Korea.
EM Bklee@kiha21.or.kr
OI Park, Sunmin/0000-0002-6092-8340
CR Ando K, 2009, FREE RADICAL BIO MED, V47, P213, DOI 10.1016/j.freeradbiomed.2009.04.030
   [Anonymous], 2013, NUTR PREVENTION TREA
   Avignon A, 2012, NUTRITION, V28, P715, DOI 10.1016/j.nut.2012.01.001
   Bian SS, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-106
   Bokov A, 2004, MECH AGEING DEV, V125, P811, DOI 10.1016/j.mad.2004.07.009
   Chiplonkar SA, 2004, J AM COLL NUTR, V23, P239, DOI 10.1080/07315724.2004.10719367
   Coyne T, 2009, BRIT J NUTR, V102, P1668, DOI 10.1017/S000711450999081X
   Day Caroline, 2007, Diab Vasc Dis Res, V4, P32, DOI 10.3132/dvdr.2007.003
   Esmaillzadeh A, 2006, AM J CLIN NUTR, V84, P1489, DOI 10.1093/ajcn/84.6.1489
   Fonseca MJ, 2012, NUTR J, V11, DOI 10.1186/1475-2891-11-64
   Grattagliano I, 2008, J NUTR BIOCHEM, V19, P491, DOI 10.1016/j.jnutbio.2007.06.011
   Grundy SM, 2007, J CLIN ENDOCR METAB, V92, P399, DOI 10.1210/jc.2006-0513
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Hostmark AT, 2010, APPL PHYSIOL NUTR ME, V35, P816, DOI 10.1139/H10-080
   Johnston CS, 2007, J NUTR, V137, P1757, DOI 10.1093/jn/137.7.1757
   Jones DP, 2010, DIABETES OBES METAB, V12, P116, DOI 10.1111/j.1463-1326.2010.01266.x
   Khalil A, 2011, EXP GERONTOL, V46, P475, DOI 10.1016/j.exger.2011.02.002
   Kim J, 2011, J AM DIET ASSOC, V111, P1141, DOI 10.1016/j.jada.2011.05.001
   Kouki R, 2011, EUR J CLIN NUTR, V65, P368, DOI 10.1038/ejcn.2010.262
   Lee BK, 2011, METABOLISM, V60, P1416, DOI 10.1016/j.metabol.2011.02.008
   Li YR, 2013, ASIA PAC J CLIN NUTR, V22, P60, DOI 10.6133/apjcn.2013.22.1.06
   Mandavia CH, 2012, METABOLISM, V61, P1205, DOI 10.1016/j.metabol.2012.02.013
   Yubero-Serrano EM, 2013, EXP MOL MED, V45, DOI 10.1038/emm.2013.53
   Marquezine GF, 2008, INT J CARDIOL, V129, P259, DOI 10.1016/j.ijcard.2007.07.097
   Maury E, 2010, MOL CELL ENDOCRINOL, V314, P1, DOI 10.1016/j.mce.2009.07.031
   Meigs JB, 2003, DIABETES, V52, P2160, DOI 10.2337/diabetes.52.8.2160
   Naziroglu M, 2004, CLIN CHIM ACTA, V344, P63, DOI 10.1016/j.cccn.2004.01.031
   Naziroglu M, 2012, NEUROCHEM RES, V37, P2065, DOI 10.1007/s11064-012-0850-x
   O'Neil CE, 2012, NUTR J, V11, DOI 10.1186/1475-2891-11-107
   Otto MCD, 2012, J NUTR, V142, P526, DOI 10.3945/jn.111.149781
   Ozkanlar S, 2012, ADV CLIN EXP MED, V21, P115
   Palmieri VO, 2006, J NUTR, V136, P3022, DOI 10.1093/jn/136.12.3022
   Qiao Q, 2006, DIABETOLOGIA, V49, P2837, DOI 10.1007/s00125-006-0438-6
   Ramirez-Tortosa MC, 2004, BRIT J NUTR, V91, P943, DOI 10.1079/BJN20041146
   Riccioni G, 2012, INT J VITAM NUTR RES, V82, P15, DOI 10.1024/0300-9831/a000090
   Ruderman NB, 2013, J CLIN INVEST, V123, P2764, DOI 10.1172/JCI67227
   Suzuki K, 2011, CLIN NUTR, V30, P369, DOI 10.1016/j.clnu.2010.12.006
   Zhang WH, 2013, ANN NUTR METAB, V63, P298, DOI 10.1159/000355575
   Zulet MA, 2008, J NUTR SCI VITAMINOL, V54, P347, DOI 10.3177/jnsv.54.347
NR 39
TC 75
Z9 78
U1 0
U2 20
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD JAN
PY 2015
VL 31
IS 1
BP 111
EP 118
DI 10.1016/j.nut.2014.05.011
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AX1CJ
UT WOS:000346685600016
PM 25466654
DA 2025-06-11
ER

PT J
AU Ceriello, A
AF Ceriello, Antonio
TI Thiazolidinediones as anti-inflammatory and anti-atherogenic agents
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Review
DE pioglitazone; rosiglitazone; free radicals; oxidative stress;
   anti-inflammatory; anti-atherogenic
ID TUMOR-NECROSIS-FACTOR; C-REACTIVE PROTEIN; INTIMA-MEDIA THICKNESS;
   ACTIVATED-RECEPTOR-GAMMA; TYPE-2 DIABETIC-PATIENTS; HUMAN
   ADIPOSE-TISSUE; PIOGLITAZONE CLINICAL-TRIAL; INSULIN-RESISTANCE
   SYNDROME; IMPAIRED GLUCOSE-TOLERANCE; CORONARY-ARTERY-DISEASE
AB in the last few years, there has been increasing focus on the impact of interventions on cardiovascular outcomes in patients with type 2 diabetes. Insulin resistance and hyperglycaemia often co-exist with a cluster of risk factors for coronary artery disease, but the underlying mechanisms leading to the development of such vascular complications are complex. The overproduction of free radicals in patients suffering from diabetes results in a state of oxidative stress, which leads to endothelial dysfunction and a greater risk of atherosclerosis. Moreover, inflammatory factors which play a critical role in atherothrombosis and plaque rupture are often found to be at elevated levels in this patient population.
   Thiazolidinediones (TZDs) are now routinely used to manage glucose levels, and have been suggested to influence other cardiovascular risk factors and therefore the pathways leading to macrovascular events. Consequently, recent studies have investigated the anti-inflammatory and anti-atherogenic properties of TZDs. The data available up to the present time, in the context of the emerging cardiovascular outcome profiles of rosiglitazone and pioglitazone, will be discussed here. Copyright (C) 2007 John Wiley Sons, Ltd.
C1 Univ Hosp, Warwick Med Sch, Clin Sci Res Inst, Coventry CV2 2DX, W Midlands, England.
C3 University of Warwick
RP Ceriello, A (corresponding author), Univ Hosp, Warwick Med Sch, Clin Sci Res Inst, Clin Sci Bldg,Walsgrave Campus, Coventry CV2 2DX, W Midlands, England.
EM antonio.ceriello@warwick.ac.uk
RI Ceriello, Antonio/J-9575-2016
OI Ceriello, Antonio/0000-0001-8122-3203
CR Ajjan R, 2006, ATHEROSCLEROSIS, V186, P240, DOI 10.1016/j.atherosclerosis.2005.10.042
   AKAI T, 1983, HORM METAB RES, V15, P523, DOI 10.1055/s-2007-1018778
   Anand SS, 2003, CIRCULATION, V108, P420, DOI 10.1161/01.CIR.0000080884.27358.49
   [Anonymous], 2007, LANCET, V369, P1834, DOI [10.1056/NEJMoao66224, 10.1016/S0140-6736(07)60787-9]
   Arita Y, 1999, BIOCHEM BIOPH RES CO, V257, P79, DOI 10.1006/bbrc.1999.0255
   ASHBY B, 1990, HEMATOL ONCOL CLIN N, V4, P1
   Aso Y, 2005, DIABETES CARE, V28, P2211, DOI 10.2337/diacare.28.9.2211
   Bagi Z, 2004, AM J PHYSIOL-HEART C, V286, pH742, DOI 10.1152/ajpheart.00718.2003
   Bajaj M, 2004, J CLIN ENDOCR METAB, V89, P200, DOI 10.1210/jc.2003-031315
   Bakris GL, 2006, J HYPERTENS, V24, P2047, DOI 10.1097/01.hjh.0000244955.39491.88
   BARATH P, 1990, AM J CARDIOL, V65, P297, DOI 10.1016/0002-9149(90)90291-8
   Barter PJ, 2004, CIRC RES, V95, P764, DOI 10.1161/01.RES.0000146094.59640.13
   BAUMANN H, 1994, IMMUNOL TODAY, V15, P74, DOI 10.1016/0167-5699(94)90137-6
   Berger J, 2002, ANNU REV MED, V53, P409, DOI 10.1146/annurev.med.53.082901.104018
   Blankenberg S, 2002, CIRCULATION, V106, P24, DOI 10.1161/01.CIR.0000020546.30940.92
   Bonora E, 2000, DIABETOLOGIA, V43, P156, DOI 10.1007/s001250050024
   Bots ML, 1997, CIRCULATION, V96, P1432, DOI 10.1161/01.CIR.96.5.1432
   Brownlee M, 2005, DIABETES, V54, P1615, DOI 10.2337/diabetes.54.6.1615
   Calkin Anna C, 2006, Am J Cardiovasc Drugs, V6, P15, DOI 10.2165/00129784-200606010-00003
   Campia U, 2006, CIRCULATION, V113, P867, DOI 10.1161/CIRCULATIONAHA.105.549618
   CASTELL JV, 1989, ANN NY ACAD SCI, V557, P87
   Ceriello A, 2005, CIRCULATION, V111, P2518, DOI 10.1161/01.CIR.0000165070.46111.9F
   Ceriello A, 2005, DIABETES CARE, V28, P266, DOI 10.2337/diacare.28.2.266
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Ceriello A, 2003, DIABETOLOGIA, V46, pM9, DOI 10.1007/s00125-002-0931-5
   Ceriello Antonio, 2006, Endocr Pract, V12 Suppl 1, P60
   Chiquette E, 2004, ARCH INTERN MED, V164, P2097, DOI 10.1001/archinte.164.19.2097
   Cines DB, 1998, BLOOD, V91, P3527
   Colwell John A, 2004, Am J Cardiovasc Drugs, V4, P87, DOI 10.2165/00129784-200404020-00003
   Combs TP, 2002, ENDOCRINOLOGY, V143, P998, DOI 10.1210/en.143.3.998
   Dandona P, 2004, REV ENDOCR METAB DIS, V5, P189, DOI 10.1023/B:REMD.0000032407.88070.0a
   Dandona P, 1998, J CLIN ENDOCR METAB, V83, P2907, DOI 10.1210/jc.83.8.2907
   Death AK, 2003, ATHEROSCLEROSIS, V168, P263, DOI 10.1016/S0021-9150(03)00140-0
   DEGROOT H, 1994, HEPATO-GASTROENTEROL, V41, P328
   Delerive P, 2001, J ENDOCRINOL, V169, P453, DOI 10.1677/joe.0.1690453
   Derosa G, 2005, DIABETES RES CLIN PR, V69, P5, DOI 10.1016/j.diabres.2004.10.007
   Dong FQ, 2004, CHINESE MED J-PEKING, V117, P1040
   Dormandy JA, 2005, LANCET, V366, P1279, DOI 10.1016/S0140-6736(05)67528-9
   Du XL, 2006, J CLIN INVEST, V116, P1071, DOI 10.1172/JCI23354
   Duez H, 2001, J CARDIOVASC RISK, V8, P187, DOI 10.1097/00043798-200108000-00002
   Dunn EJ, 2004, HERZ, V29, P470, DOI 10.1007/s00059-004-2607-z
   Dunn EJ, 2005, DIABETOLOGIA, V48, P1198, DOI 10.1007/s00125-005-1742-2
   Erdmann E, 2007, J AM COLL CARDIOL, V49, P1772, DOI 10.1016/j.jacc.2006.12.048
   Esposito K, 2006, DIABETES CARE, V29, P1071, DOI 10.2337/dc05-2174
   Esposito K, 2003, DIABETES CARE, V26, P1647, DOI 10.2337/diacare.26.5.1647
   FILIPPO CD, 2006, CARDIOVASC DRUG REV, V24, P77
   Forst T, 2005, HORM METAB RES, V37, P521, DOI 10.1055/s-2005-870322
   Gabay C, 1999, NEW ENGL J MED, V340, P448, DOI 10.1056/NEJM199902113400607
   Game BA, 2007, ATHEROSCLEROSIS, V192, P85, DOI 10.1016/j.atherosclerosis.2006.06.025
   GANTER U, 1989, EMBO J, V8, P3773, DOI 10.1002/j.1460-2075.1989.tb08554.x
   Gawaz M, 2005, J CLIN INVEST, V115, P3378, DOI 10.1172/JCI27196
   Gerrits CM, 2007, PHARMACOEPIDEM DR S, V16, P1065, DOI 10.1002/pds.1470
   Gerstein HC, 2006, LANCET, V368, P1096, DOI 10.1016/S0140-6736(06)69420-8
   Ghanim H, 2006, J CLIN ENDOCR METAB, V91, P3553, DOI 10.1210/jc.2005-2609
   Goldberg RB, 2005, DIABETES CARE, V28, P1547, DOI 10.2337/diacare.28.7.1547
   Goldstein BJ, 2004, J CLIN ENDOCR METAB, V89, P2563, DOI 10.1210/jc.2004-0518
   Green K, 2004, DIABETES, V53, pS110, DOI 10.2337/diabetes.53.2007.S110
   GRYGLEWSKI RJ, 1988, HYPERTENSION, V12, P530, DOI 10.1161/01.HYP.12.6.530
   Haffner SM, 2002, CIRCULATION, V106, P679, DOI 10.1161/01.CIR.0000025403.20953.23
   Haque WA, 2002, J CLIN ENDOCR METAB, V87, P2395, DOI 10.1210/jc.87.5.2395
   Harris TB, 1999, AM J MED, V106, P506, DOI 10.1016/S0002-9343(99)00066-2
   Harrison DG, 1997, J CLIN INVEST, V100, P2153, DOI 10.1172/JCI119751
   Hedblad B, 2007, J INTERN MED, V261, P293, DOI 10.1111/j.1365-2796.2007.01767.x
   HEGEWISCH S, 1990, LANCET, V335, P294, DOI 10.1016/0140-6736(90)90115-L
   Hetzel J, 2005, ARTERIOSCL THROM VAS, V25, P1804, DOI 10.1161/01.ATV.0000176192.16951.9a
   Hetzel M, 2003, THORAX, V58, P778, DOI 10.1136/thorax.58.9.778
   Hishinuma T, 2000, PROSTAG OTH LIPID M, V62, P135, DOI 10.1016/S0090-6980(00)00059-9
   Hotta K, 2000, ARTERIOSCL THROM VAS, V20, P1595, DOI 10.1161/01.ATV.20.6.1595
   Iida KT, 2003, AM J PHYSIOL-ENDOC M, V284, pE1125, DOI 10.1152/ajpendo.00430.2002
   Ishizuka T, 1998, DIABETES, V47, P1494, DOI 10.2337/diabetes.47.9.1494
   Jialal I, 2004, HYPERTENSION, V44, P6, DOI 10.1161/01.HYP.0000130484.20501.df
   JUHANVAGUE I, 1987, DIABETES METAB, V13, P331
   Kahn SE, 2006, NEW ENGL J MED, V355, P2427, DOI 10.1056/NEJMoa066224
   Kai HK, 1998, J AM COLL CARDIOL, V32, P368, DOI 10.1016/S0735-1097(98)00250-2
   Kanda T, 2004, JPN HEART J, V45, P183, DOI 10.1536/jhj.45.183
   Kato K, 1999, BIOCHEM BIOPH RES CO, V258, P431, DOI 10.1006/bbrc.1999.0648
   KERN PA, 1995, J CLIN INVEST, V95, P2111, DOI 10.1172/JCI117899
   Kern PA, 2003, DIABETES, V52, P1779, DOI 10.2337/diabetes.52.7.1779
   Koshiyama H, 2001, J CLIN ENDOCR METAB, V86, P3452, DOI 10.1210/jc.86.7.3452
   Lagrand WK, 1997, CIRCULATION, V95, P97, DOI 10.1161/01.CIR.95.1.97
   Landmesser U, 2006, EUR J CLIN PHARMACOL, V62, P13, DOI 10.1007/s00228-005-0012-z
   Langenfeld MR, 2005, CIRCULATION, V111, P2525, DOI 10.1161/01.CIR.0000165072.01672.21
   Lee J, 2002, SOUTH ECON J, V69, P175, DOI 10.2307/1061563
   LEVINE B, 1990, NEW ENGL J MED, V323, P236, DOI 10.1056/NEJM199007263230405
   Li DY, 2005, CARDIOVASC RES, V65, P907, DOI 10.1016/j.cardiores.2004.11.027
   Lindsay RS, 2002, LANCET, V360, P57, DOI 10.1016/S0140-6736(02)09335-2
   Loftus IM, 2001, EUR J VASC ENDOVASC, V21, P17, DOI 10.1053/ejvs.2000.1278
   LOTZ M, 1993, CANCER INVEST, V11, P732, DOI 10.3109/07357909309046948
   Majuri A, 2007, EUR J ENDOCRINOL, V156, P263, DOI 10.1530/eje.1.02331
   Makino H, 2006, DIABETES, V55, P2747, DOI 10.2337/db05-1683
   Marfella R, 2006, DIABETES, V55, P622, DOI 10.2337/diabetes.55.03.06.db05-0832
   Martens FMAC, 2005, J CARDIOVASC PHARM, V46, P773, DOI 10.1097/01.fjc.0000187176.13403.05
   Marx N, 2004, DIABETES, V53, P2662, DOI 10.2337/diabetes.53.10.2662
   Marx N, 2005, CIRCULATION, V112, P2792, DOI 10.1161/CIRCULATIONAHA.105.535484
   Mavri A, 2004, J INTERN MED, V255, P448, DOI 10.1046/j.1365-2796.2003.01288.x
   Mazzone T, 2006, JAMA-J AM MED ASSOC, V296, P2572, DOI 10.1001/jama.296.21.joc60158
   Mehta JL, 2003, ARTERIOSCL THROM VAS, V23, P2203, DOI 10.1161/01.ATV.0000094411.98127.5F
   Miyazaki Y, 2001, DIABETOLOGIA, V44, P2210, DOI 10.1007/s001250100031
   Mori Y, 2006, ENDOCRINE, V29, P143, DOI 10.1385/ENDO:29:1:143
   Nissen SE, 2007, NEW ENGL J MED, V356, P2457, DOI 10.1056/NEJMoa072761
   Noji Y, 2001, CLIN CHEM LAB MED, V39, P380, DOI 10.1515/CCLM.2001.060
   NOLAN RD, 1994, DIABETES, V43, pA101
   Otto C, 2006, J ENDOCRINOL INVEST, V29, P231, DOI 10.1007/BF03345545
   Pasceri V, 2000, CIRCULATION, V101, P235, DOI 10.1161/01.CIR.101.3.235
   PEPYS MB, 1981, LANCET, V1, P653
   Pfützner A, 2005, J AM COLL CARDIOL, V45, P1925, DOI 10.1016/j.jacc.2005.03.041
   Picchi A, 2006, CIRC RES, V99, P69, DOI 10.1161/01.RES.0000229685.37402.80
   Pickup JC, 1997, DIABETOLOGIA, V40, P1286, DOI 10.1007/s001250050822
   Pischon T, 2004, JAMA-J AM MED ASSOC, V291, P1730, DOI 10.1001/jama.291.14.1730
   Psaty BM, 2007, NEW ENGL J MED, V356, P2522, DOI 10.1056/NEJMe078099
   Rahbar S, 2000, CLIN CHIM ACTA, V301, P65, DOI 10.1016/S0009-8981(00)00327-2
   Ray DM, 2006, BIODRUGS, V20, P231, DOI 10.2165/00063030-200620040-00004
   Ricote M, 1998, NATURE, V391, P79, DOI 10.1038/34178
   Ridker PM, 2000, CIRCULATION, V101, P2149, DOI 10.1161/01.CIR.101.18.2149
   Ridker PM, 2004, CIRCULATION, V109, P6, DOI 10.1161/01.CIR.0000133444.17867.56
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Rus HG, 1996, ATHEROSCLEROSIS, V127, P263, DOI 10.1016/S0021-9150(96)05968-0
   SAADEDDIN SM, 2002, MED SCI MONITOR, V8, pR12
   Satoh N, 2003, DIABETES CARE, V26, P2493, DOI 10.2337/diacare.26.9.2493
   SCHMIDT AM, 1994, ARTERIOSCLER THROMB, V14, P1521, DOI 10.1161/01.ATV.14.10.1521
   Schneider CA, 2006, CURR MED RES OPIN, V22, pS15, DOI 10.1185/030079906X112723
   SCHNEIDERMAN J, 1992, P NATL ACAD SCI USA, V89, P6998, DOI 10.1073/pnas.89.15.6998
   Shimizu H, 2006, DIABETIC MED, V23, P253, DOI 10.1111/j.1464-5491.2006.01776.x
   Shiojiri T, 2002, EUR J PHARMACOL, V448, P231, DOI 10.1016/S0014-2999(02)01946-5
   Sidhu JS, 2004, AM HEART J, V147, DOI 10.1016/j.ahj.2003.12.035
   Sidhu JS, 2004, ARTERIOSCL THROM VAS, V24, P930, DOI 10.1161/01.ATV.0000124890.40436.77
   Sigrist S, 2000, BIOCHEM PHARMACOL, V60, P67, DOI 10.1016/S0006-2952(00)00299-9
   Sivarajah A, 2003, AM J NEPHROL, V23, P267, DOI 10.1159/000072088
   Skurk T, 2004, INT J OBESITY, V28, P1357, DOI 10.1038/sj.ijo.0802778
   Sourij H, 2006, DIABETES CARE, V29, P1039, DOI 10.2337/dc05-2226
   Spranger J, 2003, LANCET, V361, P226, DOI 10.1016/S0140-6736(03)12255-6
   Staels B, 2005, CURR MED RES OPIN, V21, pS13, DOI 10.1185/030079905X36440
   Steinberg HO, 2000, DIABETES, V49, P1231, DOI 10.2337/diabetes.49.7.1231
   Szapary PO, 2006, ARTERIOSCL THROM VAS, V26, P182, DOI 10.1161/01.ATV.0000195790.24531.4f
   TIPPING PG, 1993, AM J PATHOL, V142, P1721
   Touboul PJ, 2000, CIRCULATION, V102, P313
   Trujillo ME, 2005, J INTERN MED, V257, P167, DOI 10.1111/j.1365-2796.2004.01426.x
   Tsuji T, 2002, CARDIOVASC DRUG THER, V16, P429, DOI 10.1023/A:1022138519281
   Tsuji T, 2001, J CARDIOVASC PHARM, V38, P868, DOI 10.1097/00005344-200112000-00008
   Vergès B, 2005, DIABETES METAB, V31, P429, DOI 10.1016/S1262-3636(07)70213-6
   Vergès BL, 1999, DIABETES METAB, V25, P32
   Vinik AI, 2001, DIABETES CARE, V24, P1476, DOI 10.2337/diacare.24.8.1476
   Wagenknecht LE, 1997, STROKE, V28, P999, DOI 10.1161/01.STR.28.5.999
   Wang TD, 2006, AM J CARDIOL, V98, P1057, DOI 10.1016/j.amjcard.2006.05.027
   WARNER SJC, 1989, J IMMUNOL, V142, P100
   WAUTIER JL, 1994, P NATL ACAD SCI USA, V91, P7742, DOI 10.1073/pnas.91.16.7742
   Wayman NS, 2002, FASEB J, V16, P1027, DOI 10.1096/fj.01-0793com
   Wilcox R, 2007, STROKE, V38, P865, DOI 10.1161/01.STR.0000257974.06317.49
   Willson TM, 2001, ANNU REV BIOCHEM, V70, P341, DOI 10.1146/annurev.biochem.70.1.341
   Yki-Jarvinen H, 2004, NEW ENGL J MED, V351, P1106, DOI 10.1056/NEJMra041001
   YOKOYAMA T, 1993, J CLIN INVEST, V92, P2303, DOI 10.1172/JCI116834
   Yudkin JS, 1999, ARTERIOSCL THROM VAS, V19, P972, DOI 10.1161/01.ATV.19.4.972
   Zirlik A, 2004, THROMB HAEMOSTASIS, V91, P674, DOI 10.1160/TH03-06-0384
   2007, N ENGL J MED
NR 154
TC 83
Z9 95
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD JAN-FEB
PY 2008
VL 24
IS 1
BP 14
EP 26
DI 10.1002/dmrr.790
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 254HI
UT WOS:000252577300002
PM 17990280
DA 2025-06-11
ER

PT J
AU Nyakudya, TT
   Isaiah, S
   Ayeleso, A
   Ndhlala, AR
   Mukwevho, E
   Erlwanger, KH
AF Nyakudya, Trevor Tapiwa
   Isaiah, Simon
   Ayeleso, Ademola
   Ndhlala, Ashwell Rungano
   Mukwevho, Emmanuel
   Erlwanger, Kennedy Honey
TI Short-Term Neonatal Oral Administration of Oleanolic Acid Protects
   against Fructose-Induced Oxidative Stress in the Skeletal Muscles of
   Suckling Rats
SO MOLECULES
LA English
DT Article
DE oleanolic acid; oxidative damage; neonatal programming; metabolic
   syndrome; oxidative stress; anti-oxidant enzymes; high fructose
ID DIETARY FRUCTOSE; BIRTH-WEIGHT; LIVER-INJURY; BONE-GROWTH; BODY-WEIGHT;
   OBESITY; ANTIOXIDANT; DYSFUNCTION; YOUNG; NRF2
AB Nutritional manipulations in the neonatal period are associated with the development of negative or positive health outcomes later in life. Excessive fructose consumption has been attributed to the increase in the global prevalence of metabolic syndrome (MetS) and the development of oxidative stress. Oleanolic acid (OA) has anti-diabetic and anti-obesity effects. We investigated the protective potential of orally administering OA in the neonatal period, to prevent fructose-induced oxidative stress, adverse health outcomes and maturation of the gastrointestinal tract (GIT) in suckling rats. Seven-day old Sprague-Dawley rats (N = 30) were gavaged daily with 10 mL/kg of: distilled water (DW), oleanolic acid (OA; 60 mg/kg), high fructose solution (HF; 20% w/v), or OAHF for 7 days. On day 14, tissue samples were collected to determine clinical health profiles, hepatic lipid content, and activity of anti-oxidant enzymes. Furthermore, biomarkers of oxidative stress and anti-oxidant capacity in the skeletal muscles were assessed. The gastrointestinal tract (GIT) morphometry was measured. Rats in all groups grew over the 7-day treatment period. There were no significant differences in the terminal body masses, GIT morphometry, surrogate markers of general health, liver lipid content across all treatment groups (p < 0.05). Neonatal fructose administration decreased the activity of catalase, depleted GSH and increased lipid peroxidation. However, the level of GSH and catalase activity were improved by neonatal OA treatment. Short-term oral OA administration during the critical developmental period protects against fructose-induced oxidative stress without adverse effects on health outcomes associated with MetS or precocious development of the GIT in suckling male and female rats.
C1 [Nyakudya, Trevor Tapiwa] Univ Johannesburg, Fac Hlth Sci, Dept Human Anat & Physiol, ZA-2028 Johannesburg, South Africa.
   [Isaiah, Simon; Mukwevho, Emmanuel] North West Univ, Dept Biochem, Fac Nat Sci & Agr, ZA-2735 Mafikeng, Mmabatho, South Africa.
   [Ayeleso, Ademola] Adeleke Univ, Dept Biochem, Fac Sci, PMB 250, Ede 232, Osun State, Nigeria.
   [Ndhlala, Ashwell Rungano] Agr Res Council, VOP, Private Bag X293, ZA-0001 Pretoria, South Africa.
   [Erlwanger, Kennedy Honey] Univ Witwatersrand, Fac Hlth Sci, Sch Physiol, ZA-2193 Johannesburg, South Africa.
C3 University of Johannesburg; North West University - South Africa;
   Agricultural Research Council of South Africa; University of
   Witwatersrand
RP Ndhlala, AR (corresponding author), Agr Res Council, VOP, Private Bag X293, ZA-0001 Pretoria, South Africa.
EM trevorn@uj.ac.za; salmonovic@gmail.com; ademola.ayeleso@gmail.com;
   NdhlalaA@arc.agric.za; Emmanuel.Mukwevho@nwu.ac.za;
   Kennedy.Erlwanger@wits.ac.za
RI Mukwevho, Emmanuel/G-8962-2014; Erlwanger, Kennedy/AAX-2616-2020;
   Ndhlala, Ashwell/B-6595-2009; Nyakudya, Trevor/ABD-7926-2021
OI Nyakudya, Trevor/0000-0003-1872-9257; ISAIAH, SIMON/0000-0002-7471-3877;
   Mukwevho, Emmanuel/0000-0001-8800-955X
FU Faculty of Health Sciences Research Committee of the University of the
   Witwatersrand, Johannesburg; National Research Foundation of South
   Africa; Department of Higher Education and Training; University of
   Johannesburg, Department of Human Anatomy and Physiology
FX The authors wish to acknowledge the Faculty of Health Sciences Research
   Committee of the University of the Witwatersrand, Johannesburg, the
   National Research Foundation of South Africa and, the Department of
   Higher Education and Training for funding the research. The University
   of Johannesburg, Department of Human Anatomy and Physiology is also
   appreciated for financial support.
CR ABDEL-KAWI S.H., 2016, Beni-Suef University Journal of Basic and Applied Sciences, V5, P52, DOI DOI 10.1016/j.bjbas.2015.12.002
   Ahlman H, 2001, ANN ONCOL, V12, pS63, DOI 10.1093/annonc/12.suppl_2.S63
   [Anonymous], EPIGENOME DEV ORIGIN
   [Anonymous], HEPATOBILIARY SURG N
   Armitage JA, 2005, J PHYSIOL-LONDON, V565, P3, DOI 10.1113/jphysiol.2004.079756
   BARKER DJP, 1993, LANCET, V341, P938, DOI 10.1016/0140-6736(93)91224-A
   Bechmann LP, 2012, J HEPATOL, V56, P952, DOI 10.1016/j.jhep.2011.08.025
   Benevenga N.J., 1995, NUTRIENT REQUIREMENT, P140
   Benzie IFF, 1996, ANAL BIOCHEM, V239, P70, DOI 10.1006/abio.1996.0292
   Beya W, 2012, AFR J TRADIT COMPLEM, V9, P553, DOI 10.4314/ajtcam.v9i4.13
   Botermans JAM, 1999, J ANIM SCI, V77, P450
   Brisco MA, 2013, CIRC-HEART FAIL, V6, P233, DOI 10.1161/CIRCHEARTFAILURE.112.968230
   Buege J A, 1978, Methods Enzymol, V52, P302
   Camer D, 2014, MOL NUTR FOOD RES, V58, P1750, DOI 10.1002/mnfr.201300861
   Carvounis CP, 2002, KIDNEY INT, V62, P2223, DOI 10.1046/j.1523-1755.2002.00683.x
   Castellano JM, 2016, GRASAS ACEITES, V67, DOI 10.3989/gya.1237153
   Castellano JM, 2013, DIABETES, V62, P1791, DOI 10.2337/db12-1215
   Chai J, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0120055
   Chen B, 2015, J ENDOCRINOL, V225, pR83, DOI 10.1530/JOE-14-0662
   Chen XL, 2004, CURR PHARM DESIGN, V10, P879, DOI 10.2174/1381612043452901
   Cigliano L, 2018, MOL NEUROBIOL, V55, P2869, DOI 10.1007/s12035-017-0518-2
   Clancy B, 2001, NEUROSCIENCE, V105, P7, DOI 10.1016/S0306-4522(01)00171-3
   Corey KE, 2014, CLIN LIVER DIS, V18, P1, DOI 10.1016/j.cld.2013.09.019
   Curhan GC, 1996, CIRCULATION, V94, P3246, DOI 10.1161/01.CIR.94.12.3246
   Date Y, 2000, ENDOCRINOLOGY, V141, P4255, DOI 10.1210/en.141.11.4255
   DIk B., 2013, Ataturk Universitesi Veteriner Bilimleri Dergisi, V8, P259
   DOWNES NJ, 2008, REPROD TOXICOL, V26, P60, DOI DOI 10.1016/J.REPROTOX.2008.05.013
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Guilloteau P, 2010, NUTR RES REV, V23, P4, DOI 10.1017/S0954422410000077
   Hack M, 2002, NEW ENGL J MED, V346, P149, DOI 10.1056/NEJMoa010856
   Heemskerk S, 2009, CRIT CARE MED, V37, P417, DOI 10.1097/CCM.0b013e31819598af
   HENNING SJ, 1981, AM J PHYSIOL, V241, pG199, DOI 10.1152/ajpgi.1981.241.3.G199
   Henning SJ., 1987, PHYSL GASTROINTESTIN, P285
   Higdon JV, 2003, ARTERIOSCL THROM VAS, V23, P365, DOI 10.1161/01.ATV.0000063608.43095.E2
   Huynh M, 2008, OBESITY, V16, P1755, DOI 10.1038/oby.2008.268
   Jäger S, 2009, MOLECULES, V14, P2016, DOI 10.3390/molecules14062016
   Jarukamjorn K., 2016, SCIENTIFICA, V2016, DOI [10.1155/2016/5029414, DOI 10.1155/2016/5029414]
   Jean M., 1993, J DAIRY SCI, V76, P2080
   Khan IY, 2005, AM J PHYSIOL-REG I, V288, pR127, DOI 10.1152/ajpregu.00354.2004
   Khathi A, 2015, ENDOCRINOL ABS, DOI DOI 10.1530/ENDOABS.38.P224
   Khitan Z, 2013, J NUTR METAB, V2013, DOI 10.1155/2013/682673
   Kozakowska M, 2015, J MUSCLE RES CELL M, V36, P377, DOI 10.1007/s10974-015-9438-9
   La Russa D, 2017, CLIN SCI, V131, P1419, DOI 10.1042/CS20170177
   Lane G., 2016, J NUTR THERAP, V4, P113
   Leise M.D., 2014, Drug-induced liver injury, Mayo clinic proceedings, P95
   Limdi JK, 2003, POSTGRAD MED J, V79, P307, DOI 10.1136/pmj.79.932.307
   Liu J, 1995, J ETHNOPHARMACOL, V49, P57, DOI 10.1016/0378-8741(95)90032-2
   LIU J, 1994, FUND APPL TOXICOL, V22, P34, DOI 10.1006/faat.1994.1005
   LIU J, 1995, ACTA PHARM SINIC, V16, P97
   Liu RH, 2003, AM J CLIN NUTR, V78, p517S, DOI 10.1093/ajcn/78.3.517S
   Lucas A, 1998, J NUTR, V128, p401S, DOI 10.1093/jn/128.2.401S
   MAARMAN G., 2016, Journal of African Association of Physiological Sciences, V4, P71
   MALTIN CA, 1986, BIOSCIENCE REP, V6, P293, DOI 10.1007/BF01115158
   McArdle HJ, 2006, PLACENTA, V27, pS56, DOI 10.1016/j.placenta.2006.01.014
   McCance K.L., 1994, DIMEN CRIT CARE NURS, V13, P6
   Moseley RH, 1996, MED CLIN N AM, V80, P887, DOI 10.1016/S0025-7125(05)70472-7
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Oosterveer MH, 2014, CELL MOL LIFE SCI, V71, P1453, DOI 10.1007/s00018-013-1505-z
   Ou BX, 2001, J AGR FOOD CHEM, V49, P4619, DOI 10.1021/jf010586o
   Pall Martin L., 2015, Shengli Xuebao, V67, P1
   Gutiérrez RMP, 2017, ARCH PHARM RES, V40, P550, DOI 10.1007/s12272-016-0873-y
   Picó C, 2007, INT J OBESITY, V31, P1199, DOI 10.1038/sj.ijo.0803585
   Quinn R, 2005, NUTRITION, V21, P775, DOI 10.1016/j.nut.2005.04.002
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   ROTRUCK JT, 1973, SCIENCE, V179, P588, DOI 10.1126/science.179.4073.588
   Rouiller C., 2013, The liver: morphology, biochemistry, physiology
   Rui LY, 2014, COMPR PHYSIOL, V4, P177, DOI 10.1002/cphy.c130024
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Salminen S, 1998, BRIT J NUTR, V80, pS147, DOI 10.1079/BJN19980108
   Sánchez-Quesada C, 2015, MOLECULES, V20, P13670, DOI 10.3390/molecules200813670
   Sankhla M, 2012, CLIN LAB, V58, P385
   Savini I, 2013, INT J MOL SCI, V14, P10497, DOI 10.3390/ijms140510497
   Scheig R, 1996, PRIMARY CARE, V23, P551, DOI 10.1016/S0095-4543(05)70347-X
   Seedor JG, 2005, J BONE MINER RES, V20, P355
   Sengupta P, 2013, INT J PREVENTIVE MED, V4, P624
   Shu R, 1997, AM J PHYSIOL-GASTR L, V272, pG446, DOI 10.1152/ajpgi.1997.272.3.G446
   Sikora E, 2010, Immun Ageing, V7, P1, DOI 10.1186/1742-4933-7-1
   Singhal A, 2004, CIRCULATION, V109, P1108, DOI 10.1161/01.CIR.0000118500.23649.DF
   SINHA AK, 1972, ANAL BIOCHEM, V47, P389, DOI 10.1016/0003-2697(72)90132-7
   Stanhope KL, 2016, CRIT REV CL LAB SCI, V53, P52, DOI 10.3109/10408363.2015.1084990
   Sundström K, 2014, ENDOCRINOLOGY, V155, P4798, DOI 10.1210/en.2014-1160
   Tangvarasittichai S, 2015, WORLD J DIABETES, V6, P456, DOI 10.4239/wjd.v6.i3.456
   Tappy L., 2017, Sweeteners: Pharmacology, Biotechnology, and Applications, P1
   Thapa BR, 2007, INDIAN J PEDIATR, V74, P663, DOI 10.1007/s12098-007-0118-7
   Tian T, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/4535194
   Tsao SM, 2015, J AGR FOOD CHEM, V63, P3196, DOI 10.1021/acs.jafc.5b00102
   Vella SJ, 2012, ANAL CHEM, V84, P2883, DOI 10.1021/ac203434x
   Vickers MH, 2011, WORLD J DIABETES, V2, P137, DOI 10.4239/wjd.v2.i9.137
   Wang X, 2010, CHEM-BIOL INTERACT, V184, P328, DOI 10.1016/j.cbi.2010.01.034
   Wang XM, 2013, WORLD J PEDIATR, V9, P5, DOI 10.1007/s12519-013-0403-7
   Wang X, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/973287
   Yakar S, 2002, J CLIN INVEST, V110, P771, DOI 10.1172/JCI200215463
   Yang HJ, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-396
   YIN FCP, 1982, AM J PHYSIOL, V243, pH941, DOI 10.1152/ajpheart.1982.243.6.H941
NR 95
TC 9
Z9 9
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD FEB 2
PY 2019
VL 24
IS 4
AR 661
DI 10.3390/molecules24040661
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HO3FS
UT WOS:000460805900007
PM 30781794
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Gianotti, A
   Marin, V
   Cardone, G
   Bordoni, A
   Mancini, E
   Magni, M
   Pichler, A
   Ciani, S
   Polenghi, O
   Cerne, VL
   Nissen, L
AF Gianotti, Andrea
   Marin, Veronica
   Cardone, Gaetano
   Bordoni, Alessandra
   Mancini, Elisa
   Magni, Martina
   Pichler, Andrea
   Ciani, Silvano
   Polenghi, Ombretta
   Cerne, Virna Lucia
   Nissen, Lorenzo
TI Personalized and precise functional assessment of innovative flatbreads
   toward the colon microbiota of people with metabolic syndrome: Results
   from an in vitro simulation
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Article
DE Tailored-food; Food by-products; Plant-based antioxidant; Fortification;
   Clinical nutrition; In vitro gut model
ID GUT MICROBIOTA; FOOD; MECHANISMS; GENERATION; BACTERIA; STRESS
AB Due to the increasing incidence of individuals with metabolic syndrome and the higher correlations between metabolic syndrome and the gut microbiota, there is a need to formulate functional foods that can promote the development of beneficial microorganisms within the gut microbiota. This study aims to evaluate the possible positive effects of innovative gluten-free flatbread, containing grape and apple antioxidant-rich by-products, on the gut microbiota of patients with metabolic syndrome. The baked products were subjected to gastric digestion using the Infogest system, followed by proximal colonic fermentation in the MICODE (Multi-Unit In vitro Colon Model) intestinal model, where three samplings were performed (baseline, after 16 h and 24 h). The samples were then subjected to 16S rRNA metataxonomy, quantification of shifts in bacterial populations by qPCR analysis and characterization of volatile organic compounds by SPME GC-MS (Solid Phase Micro Extraction Gas-Chromatography Mass-Spectrophotometry). A robust statistical approach based on several tests and multivariate analysis was applied. The results obtained demonstrated the in vitro potential of functional flatbreads in improving the dysbiosis of the microbiota of individuals with metabolic syndrome, due to a reduction in the Firmicutes/Bacteroidota ratio, and highlighted an increase in commensal microorganisms (Bifidobacterium, positive clostridia and Akkermansia muciniphila) and a reduction in negative microorganisms (Enterobacteriaceae, negative clostridia and Collinsella spp.). The analysis of metabolites showed an increase in health-beneficial metabolites (acetate and medium chain organic acids) and a reduction in harmful metabolites (p-cresol and skatole), the degree of this modulation varied based on the flatbread composition. While this study employed an in vitro model of recognized limitations, it nonetheless provides valuable, evidence-based results that can be used for preclinical screening of formulations. Anyhow this work is of high fashion in this running time as it proposes i) in vitro models rather than animal testing; ii) human MetS gut microbiota for high translatability to in vivo condition; iii) approaches of precise and personalized nutrition by the use of specific microbiota and omic technologies, all component that vow to be the future of food assessment.
C1 [Gianotti, Andrea; Bordoni, Alessandra; Nissen, Lorenzo] Univ Bologna, Alma Mater Studiorum, DISTAL Dept Agr & Food Sci, Food Sci Campus Pza G Goidanich 60, I-47521 Cesena, Italy.
   [Gianotti, Andrea; Bordoni, Alessandra; Nissen, Lorenzo] Alma Mater Studiorum Univ Bologna, CIRI Interdept Ctr Agrifood Ind Res, Pza G Goidanich 60, I-47521 Cesena, Italy.
   [Marin, Veronica; Cardone, Gaetano; Ciani, Silvano; Polenghi, Ombretta; Cerne, Virna Lucia] Dr Schar R&D Ctr, Area Sci Pk Padriciano 99, I-34149 Trieste, Italy.
   [Mancini, Elisa] Private Nutr Clin, Piazza Polesani nel Mondo 16, I-45100 Boara Polesine, RO, Italy.
   [Magni, Martina; Pichler, Andrea] Laimburg Res Ctr, Auer, BZ, Italy.
C3 University of Bologna; University of Bologna; Laimburg Research Center
RP Gianotti, A (corresponding author), Univ Bologna, Alma Mater Studiorum, DISTAL Dept Agr & Food Sci, Food Sci Campus Pza G Goidanich 60, I-47521 Cesena, Italy.
EM andrea.gianotti@unibo.it
RI Nissen, Lorenzo/AAF-6534-2020; Gianotti, Andrea/Y-3887-2019
FU Autonomous Province of Bozen/Bolzano
FX This research was partially founded by Autonomous Province of
   Bozen/Bolzano in the context of the project entitled "REAliSM"
   Regionalita ed. Eco-circolarita in ALImenti per contrastare la Sindrome
   Metabolica (Regionalism and eco-circularity in food to counteract
   Metabolic Syndrome).
CR Abenavoli L, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112690
   Altayb HN, 2023, FRONT PUBLIC HEALTH, V10, DOI 10.3389/fpubh.2022.1068888
   Alves-Santos AM, 2020, J FUNCT FOODS, V74, DOI 10.1016/j.jff.2020.104169
   Arnal ME, 2021, BENEF MICROBES, V12, P75, DOI 10.3920/BM2020.0187
   Babicki S, 2016, NUCLEIC ACIDS RES, V44, pW147, DOI 10.1093/nar/gkw419
   Bolyen E, 2019, NAT BIOTECHNOL, V37, P852, DOI 10.1038/s41587-019-0209-9
   Bonfrate L, 2020, EUR J CLIN INVEST, V50, DOI 10.1111/eci.13201
   Brown L, 2015, OBES REV, V16, P914, DOI 10.1111/obr.12313
   Campos DA, 2020, MOLECULES, V25, DOI 10.3390/molecules25020320
   Cattivelli A, 2023, FOOD FUNCT, V14, P3509, DOI [10.1039/D3FO00085K, 10.1039/d3fo00085k]
   Ceci AT, 2021, METABOLITES, V11, DOI 10.3390/metabo11060378
   Chen D, 2024, INT J BIOL MACROMOL, V279, DOI 10.1016/j.ijbiomac.2024.135340
   Connolly ML, 2010, ANAEROBE, V16, P483, DOI 10.1016/j.anaerobe.2010.07.001
   Di Cagno R, 2011, BMC MICROBIOL, V11, DOI 10.1186/1471-2180-11-219
   Diotallevi C, 2021, J FUNCT FOODS, V84, DOI 10.1016/j.jff.2021.104597
   Doi J., 2016, Technology Innovations in Statistics Education, V9, P1, DOI [DOI 10.5070/T591027492, 10.5070/t591027492]
   Edgar RC, 2010, BIOINFORMATICS, V26, P2460, DOI 10.1093/bioinformatics/btq461
   Festi D, 2014, WORLD J GASTROENTERO, V20, P16079, DOI 10.3748/wjg.v20.i43.16079
   Frost F, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0219489
   Gargari G, 2024, GUT MICROBES, V16, DOI 10.1080/19490976.2023.2298246
   Goedhart J, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-76603-3
   Granato D, 2014, FOOD RES INT, V55, P137, DOI 10.1016/j.foodres.2013.10.024
   Guerzoni ME, 2007, FOOD MICROBIOL, V24, P139, DOI 10.1016/j.fm.2006.07.007
   Hajjar DP, 2013, AM J PATHOL, V182, P1474, DOI 10.1016/j.ajpath.2013.01.010
   Hassan NE, 2024, SCI REP-UK, V14, DOI 10.1038/s41598-024-61130-2
   He NN, 2024, J FUNCT FOODS, V115, DOI 10.1016/j.jff.2024.106106
   Hill CJ, 2017, MICROBIOME, V5, DOI 10.1186/s40168-016-0213-y
   Koliada A, 2017, BMC MICROBIOL, V17, DOI 10.1186/s12866-017-1027-1
   Kumari M, 2021, FOOD RES INT, V150, DOI 10.1016/j.foodres.2021.110716
   LeBlanc JG, 2017, MICROB CELL FACT, V16, DOI 10.1186/s12934-017-0691-z
   Logan BK, 2000, MED SCI LAW, V40, P206, DOI 10.1177/002580240004000304
   Love MI, 2014, GENOME BIOL, V15, DOI 10.1186/s13059-014-0550-8
   Magne F, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051474
   Makras L, 2006, INT DAIRY J, V16, P1049, DOI 10.1016/j.idairyj.2005.09.006
   Malinen E, 2010, WORLD J GASTROENTERO, V16, P4532, DOI 10.3748/wjg.v16.i36.4532
   Marino M, 2019, FOOD MICROBIOL, V79, P123, DOI 10.1016/j.fm.2018.12.007
   Martirosyan D, 2021, FUNCT FOODS HEALTH D, V11, P213, DOI 10.31989/ffhd.v11i5.788
   McDonald D, 2012, ISME J, V6, P610, DOI 10.1038/ismej.2011.139
   Minekus M, 2014, FOOD FUNCT, V5, P1113, DOI 10.1039/c3fo60702j
   Modesto M, 2011, NJAS-WAGEN J LIFE SC, V58, P149, DOI 10.1016/j.njas.2011.04.001
   Mohamed S.M., 2023, Food Chem Adv, V3, DOI 10.1016/j.focha.2023.100335
   Nissen L, 2024, FOOD CHEM, V436, DOI 10.1016/j.foodchem.2023.137633
   Nissen L, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-27726-w
   Nissen L, 2021, FOODS, V10, DOI 10.3390/foods10102371
   Nogal A, 2021, GUT MICROBES, V13, DOI 10.1080/19490976.2021.1897212
   Oba S, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-74379-0
   Restivo I, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12081621
   Rodríguez-Daza MC, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.689456
   Samuel BS, 2007, P NATL ACAD SCI USA, V104, P10643, DOI 10.1073/pnas.0704189104
   Sartor RB, 2008, P NATL ACAD SCI USA, V105, P16413, DOI 10.1073/pnas.0809363105
   Sears CL, 1996, MICROBIOL REV, V60, P167, DOI 10.1128/MMBR.60.1.167-215.1996
   Shen J, 2013, MOL ASPECTS MED, V34, P39, DOI 10.1016/j.mam.2012.11.001
   Spitzer M, 2014, NAT METHODS, V11, P121, DOI 10.1038/nmeth.2811
   Su LL, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-05127-9
   Tamargo A, 2022, FOOD RES INT, V155, DOI 10.1016/j.foodres.2022.111010
   Tanner SA, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094123
   Traore SI, 2019, CLIN MICROBIOL INFEC, V25, DOI 10.1016/j.cmi.2019.04.008
   Trost K, 2018, FOOD RES INT, V112, P108, DOI 10.1016/j.foodres.2018.06.016
   Tsitko I, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20081925
   Vaiserman A, 2020, BMC MICROBIOL, V20, DOI 10.1186/s12866-020-01903-7
   Vázquez-Baeza Y, 2013, GIGASCIENCE, V2, DOI 10.1186/2047-217X-2-16
   Wang Q, 2007, APPL ENVIRON MICROB, V73, P5261, DOI 10.1128/AEM.00062-07
   Wang XD, 2020, APPL ENVIRON MICROB, V86, DOI 10.1128/AEM.02730-19
   Westfall S, 2018, ARTIF CELL NANOMED B, V46, P441, DOI 10.1080/21691401.2018.1458731
   Ziemons J, 2024, BMC MICROBIOL, V24, DOI 10.1186/s12866-024-03384-4
NR 65
TC 0
Z9 0
U1 3
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0963-9969
EI 1873-7145
J9 FOOD RES INT
JI Food Res. Int.
PD MAY
PY 2025
VL 209
AR 116197
DI 10.1016/j.foodres.2025.116197
PG 13
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 1KP3S
UT WOS:001467252700001
PM 40253173
DA 2025-06-11
ER

PT J
AU Shabbir, MA
   Mehak, F
   Khan, ZM
   Ahmad, W
   Khan, MR
   Zia, S
   Rahaman, A
   Aadil, RM
AF Shabbir, Muhammad Asim
   Mehak, Fakiha
   Khan, Zaira Mumal
   Ahmad, Waqar
   Khan, Moazzam Rafiq
   Zia, Sania
   Rahaman, Abdul
   Aadil, Rana Muhammad
TI Interplay between ceramides and phytonutrients: New insights in
   metabolic syndrome
SO TRENDS IN FOOD SCIENCE & TECHNOLOGY
LA English
DT Article
DE Ceramides; Metabolic syndrome; Phytonutrients; Sphingolipids; Obesity
ID INDUCED INSULIN-RESISTANCE; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS;
   CORONARY-ARTERY-DISEASE; SPHINGOLIPID METABOLISM; RECEPTOR SUBSTRATE-1;
   PROTEIN PHOSPHATASE; PLASMA CERAMIDES; SIGNALING AXIS; HIGH-FAT;
   INFLAMMATION
AB Background: Ceramides are a novel biomarker for numerous obesity-associated disorders such as type II diabetes mellitus (T2D) and atherosclerosis. Ceramides were considered as a relatively homogeneous class of sphingolipids. Ceramides generally have a wide length of the fatty acyl chain that take part in different metabolic processes. Modulation of ceramide synthesis in certain cellular components along with its metabolism has a significant influence on metabolic homeostasis.
   Scope and approach: In this review, major role of ceramides in metabolic syndrome and the ability of certain phytonutrients to manage ceramides levels have been discussed. Ceramides act as an intracellular signaling molecules that affect the metabolism through different pathways such as adiposity linkage, insulin resistance and cardiometabolic syndrome. In addition, phytonutrients are novel therapeutic agents that may lower plasma ceramide levels involved in metabolic syndrome. Furthermore, relationship between ceramides and metabolic syndrome with regards to ceramide modulation and effect of bioactive phytonutrients in regulating the ceramides levels in relation to obesity-associated disorders is also elucidated.
   Key findings and conclusions: The unique structure enables ceramides to function both as structural membrane components and signaling molecules Accumulation of ceramides and their coalescence in sphingolipid-rich domains can influence cell signaling by clustering receptors. As sum of all the ceramide species present in cells usually range from 0.1 to 1.0% of total phospholipids yet may have high affinity targets. Different ceramides species usually with long n-acyl chains have been implicated in pathophysiologic processes and disease progression. Ceramides slowed lipolysis, inhibited glucose uptake, and decreased mitochondrial respiration. Certain cytokines including tumor necrosis factor alpha (TNF?) and interleukins (ILs) such as IL-1b and adiponectin, activate the sphingomyelinase enzymes. Besides inflammatory signals, ceramide production is often stimulated by oxidative stress. From literature, lipidomic analysis revealed that nutritional intervention (consuming plantbased foods as a source of phytonutrients) can help in lowering the circulating ceramides especially C16:0 and C24:0 ceramides, a potential known inhibitor of insulin signaling. However, exact mechanism of different phytonutrients involved in ceramide modulation needs to be understood at molecular level for gaining more insights at their mechanistic mode of action.
C1 [Shabbir, Muhammad Asim; Mehak, Fakiha; Khan, Zaira Mumal; Ahmad, Waqar; Khan, Moazzam Rafiq; Zia, Sania; Aadil, Rana Muhammad] Univ Agr Faisalabad, Natl Inst Food Sci & Technol, Faisalabad, Pakistan.
   [Rahaman, Abdul] South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510640, Guangdong, Peoples R China.
C3 University of Agriculture Faisalabad; South China University of
   Technology
RP Khan, MR; Aadil, RM (corresponding author), Univ Agr Faisalabad, Natl Inst Food Sci & Technol, Faisalabad, Pakistan.
EM mrkhan_ft@yahoo.com; dilrana89@gmail.com
RI Rahaman, Abdul/T-1834-2019; Zia, Sania/AAV-6365-2020; Khan, Muhammad
   Amir/JEZ-6363-2023; Shabbir, Muhammad/M-8681-2018; Khan, Muhammad
   Azzam/KCZ-1774-2024; Ahmed, Waqar/JPA-2138-2023; Aadil, Rana
   Muhammad/GRY-2404-2022
OI Aadil, Rana Muhammad/0000-0002-0185-0096; Ahmed,
   Waqar/0000-0002-0373-3897; Zia, Sania/0000-0003-0425-1766
FU University of Agriculture, Faisalabad, Pakistan
FX The authors are grateful to University of Agriculture, Faisalabad,
   Pakistan for the support.
CR Al Makdessi S, 2016, CELL PHYSIOL BIOCHEM, V39, P1608, DOI 10.1159/000447862
   Martín MA, 2014, MOL NUTR FOOD RES, V58, P447, DOI 10.1002/mnfr.201300291
   Babenko NA, 2008, LIPIDS HEALTH DIS, V7, DOI 10.1186/1476-511X-7-1
   Badi RM, 2019, CLIN EXP PHARMACOL P, V46, P545, DOI 10.1111/1440-1681.13074
   Barthelmes J, 2015, BRAIN BEHAV IMMUN, V46, P280, DOI 10.1016/j.bbi.2015.02.010
   Bharath LP, 2015, DIABETES, V64, P3914, DOI 10.2337/db15-0244
   Bikman BT, 2012, J BIOL CHEM, V287, P17426, DOI 10.1074/jbc.M112.359950
   Blouin CM, 2010, DIABETES, V59, P600, DOI 10.2337/db09-0897
   Boslem E, 2012, ISLETS, V4, P177, DOI 10.4161/isl.20102
   Catrysse L, 2017, TRENDS CELL BIOL, V27, P417, DOI 10.1016/j.tcb.2017.01.006
   Chaurasia B, 2019, SCIENCE, V365, P386, DOI 10.1126/science.aav3722
   Chaurasia B, 2016, CELL METAB, V24, P820, DOI 10.1016/j.cmet.2016.10.002
   Chaurasia B, 2015, TRENDS ENDOCRIN MET, V26, P538, DOI 10.1016/j.tem.2015.07.006
   Chavez JA, 2003, J BIOL CHEM, V278, P10297, DOI 10.1074/jbc.M212307200
   Chen TC, 2017, SCI SIGNAL, V10, DOI 10.1126/scisignal.aai7905
   Choi JS, 2014, FOOD CHEM TOXICOL, V64, P27, DOI 10.1016/j.fct.2013.11.020
   Cozma C, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-06604-2
   D'Angelo G, 2007, NATURE, V449, P62, DOI 10.1038/nature06097
   de Mello VDF, 2009, DIABETOLOGIA, V52, P2612, DOI 10.1007/s00125-009-1482-9
   DOBROWSKY RT, 1993, J BIOL CHEM, V268, P15523
   Dworski S, 2017, BBA-MOL BASIS DIS, V1863, P386, DOI 10.1016/j.bbadis.2016.11.031
   Eberle M, 2015, IMMUNOL CELL BIOL, V93, P825, DOI 10.1038/icb.2015.47
   Engin AB, 2018, FOOD CHEM TOXICOL, V112, P157, DOI 10.1016/j.fct.2017.12.055
   Ference BA, 2017, EUR HEART J, V38, P2459, DOI 10.1093/eurheartj/ehx144
   Fitzgerald S, 2015, J PATHOL CLIN RES, V1, P54, DOI 10.1002/cjp2.5
   Gao ZG, 2002, J BIOL CHEM, V277, P48115, DOI 10.1074/jbc.M209459200
   Goldstein JL, 2015, CELL, V161, P161, DOI 10.1016/j.cell.2015.01.036
   González-García I, 2018, CELL REP, V25, P413, DOI 10.1016/j.celrep.2018.09.038
   Grösch S, 2012, PROG LIPID RES, V51, P50, DOI 10.1016/j.plipres.2011.11.001
   Gupta Charu, 2014, J Complement Integr Med, V11, P151
   Haberkant P, 2016, ACS CHEM BIOL, V11, P222, DOI 10.1021/acschembio.5b00810
   Hanada K, 2003, NATURE, V426, P803, DOI 10.1038/nature02188
   Hannun YA, 2018, NAT REV MOL CELL BIO, V19, P175, DOI 10.1038/nrm.2017.107
   Hannun YA, 2011, J BIOL CHEM, V286, P27855, DOI 10.1074/jbc.R111.254359
   Hassan RH, 2016, J BIOL CHEM, V291, P3019, DOI 10.1074/jbc.M115.686949
   Haus JM, 2009, DIABETES, V58, P337, DOI 10.2337/db08-1228
   Hilvo M, 2020, EUR HEART J, V41, P371, DOI 10.1093/eurheartj/ehz387
   Hilvo M, 2018, DIABETOLOGIA, V61, P1424, DOI 10.1007/s00125-018-4590-6
   Holland WL, 2011, J CLIN INVEST, V121, P1858, DOI 10.1172/JCI43378
   Huang SJ, 2017, INT J BIOL SCI, V13, P1, DOI 10.7150/ijbs.17149
   Hulston CJ, 2015, BRIT J NUTR, V113, P596, DOI 10.1017/S0007114514004097
   Jembrek MJ, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/346783
   Kaasenbrood L, 2016, CIRCULATION, V134, P1419, DOI 10.1161/CIRCULATIONAHA.116.021314
   Kolak M, 2007, DIABETES, V56, P1960, DOI 10.2337/db07-0111
   Koybasi S, 2004, J BIOL CHEM, V279, P44311, DOI 10.1074/jbc.M406920200
   Kraus VB, 2018, NAT REV RHEUMATOL, V14, P354, DOI 10.1038/s41584-018-0005-9
   Kurz J, 2019, TRENDS MOL MED, V25, P20, DOI 10.1016/j.molmed.2018.10.009
   Laaksonen R, 2016, EUR HEART J, V37, P1967, DOI 10.1093/eurheartj/ehw148
   Lee SM, 2020, PHYTOMEDICINE, V74, DOI 10.1016/j.phymed.2019.152936
   Luukkonen PK, 2018, DIABETES CARE, V41, P1732, DOI 10.2337/dc18-0071
   Maceyka M, 2014, NATURE, V510, P58, DOI 10.1038/nature13475
   Manni MM, 2018, CHEM PHYS LIPIDS, V217, P29, DOI 10.1016/j.chemphyslip.2018.09.010
   Marais AD, 2015, PHARMACOL THERAPEUT, V145, P58, DOI 10.1016/j.pharmthera.2014.07.004
   Mathews AT, 2017, PHYSIOL REP, V5, DOI 10.14814/phy2.13329
   Meeusen JW, 2018, ARTERIOSCL THROM VAS, V38, P1933, DOI 10.1161/ATVBAHA.118.311199
   Meikle PJ, 2017, NAT REV ENDOCRINOL, V13, P79, DOI 10.1038/nrendo.2016.169
   Miñón-Hernández D, 2021, PLANT FOOD HUM NUTR, V76, P12, DOI 10.1007/s11130-020-00867-3
   Mullen TD, 2012, BIOCHEM J, V441, P789, DOI 10.1042/BJ20111626
   Mulvihill EE, 2012, PPAR RES, V2012, DOI 10.1155/2012/857142
   Bezerra RMN, 2012, METABOLISM, V61, P1606, DOI 10.1016/j.metabol.2012.04.006
   Norris GH, 2017, NUTRIENTS, V9, DOI 10.3390/nu9111180
   Ochiai T, 2007, BBA-GEN SUBJECTS, V1770, P578, DOI 10.1016/j.bbagen.2006.11.012
   Panjarian S, 2008, PROSTAG OTH LIPID M, V86, P41, DOI 10.1016/j.prostaglandins.2008.02.004
   Paraiso IL, 2020, MOL NUTR FOOD RES, V64, DOI 10.1002/mnfr.202000341
   Poss AM, 2020, EUR HEART J, V41, P381, DOI 10.1093/eurheartj/ehz525
   Powell DJ, 2003, MOL CELL BIOL, V23, P7794, DOI 10.1128/MCB.23.21.7794-7808.2003
   Rabionet M, 2014, BBA-MOL CELL BIOL L, V1841, P422, DOI 10.1016/j.bbalip.2013.08.011
   Radner FPW, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003536
   Robertson RP, 2004, J BIOL CHEM, V279, P42351, DOI 10.1074/jbc.R400019200
   Rocha VZ, 2009, NAT REV CARDIOL, V6, P399, DOI 10.1038/nrcardio.2009.55
   Rodriguez-Cuenca S, 2015, BBA-MOL CELL BIOL L, V1851, P40, DOI 10.1016/j.bbalip.2014.09.021
   Salinas M, 2000, MOL CELL NEUROSCI, V15, P156, DOI 10.1006/mcne.1999.0813
   Scheumann M, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-10417-8
   Schiffmann S, 2009, CARCINOGENESIS, V30, P745, DOI 10.1093/carcin/bgp061
   Sesti G, 2006, BEST PRACT RES CL EN, V20, P665, DOI 10.1016/j.beem.2006.09.007
   Si X, 2020, J AGR FOOD CHEM, V68, P8185, DOI 10.1021/acs.jafc.0c01931
   Simonis A, 2014, PLOS PATHOG, V10, DOI 10.1371/journal.ppat.1004160
   Sin TK, 2015, CELL PHYSIOL BIOCHEM, V35, P541, DOI 10.1159/000369718
   Sokolowska E, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00577
   Stiban J, 2019, ADV EXP MED BIOL, V1159, P1, DOI 10.1007/978-3-030-21162-2
   Summers SA, 1998, MOL CELL BIOL, V18, P5457, DOI 10.1128/MCB.18.9.5457
   Summers SA, 2018, CELL METAB, V27, P276, DOI 10.1016/j.cmet.2017.12.003
   Sun YZ, 2017, EUR J PHARMACOL, V815, P109, DOI 10.1016/j.ejphar.2017.09.010
   Teng WD, 2019, NUTRIENTS, V11, DOI 10.3390/nu11051185
   Teruel T, 2001, DIABETES, V50, P2563, DOI 10.2337/diabetes.50.11.2563
   Thomas HE, 2009, APOPTOSIS, V14, P1389, DOI 10.1007/s10495-009-0339-5
   Tuccinardi D, 2019, DIABETES OBES METAB, V21, P2086, DOI 10.1111/dom.13773
   Turpin SM, 2014, CELL METAB, V20, P678, DOI 10.1016/j.cmet.2014.08.002
   Turpin-Nolan SM, 2020, NAT REV ENDOCRINOL, V16, P224, DOI 10.1038/s41574-020-0320-5
   Turpin-Nolan SM, 2019, CELL REP, V26, P1, DOI 10.1016/j.celrep.2018.12.031
   Ussher JR, 2010, DIABETES, V59, P2453, DOI 10.2337/db09-1293
   Vanni N, 2014, ANN NEUROL, V76, P206, DOI 10.1002/ana.24170
   Wang G, 2008, GLIA, V56, P449, DOI 10.1002/glia.20626
   Wattenberg Binks W, 2010, World J Biol Chem, V1, P362, DOI 10.4331/wjbc.v1.i12.362
   Westra B, 2016, MAYO MEDICAL LAB
   Wigger L, 2017, CELL REP, V18, P2269, DOI 10.1016/j.celrep.2017.02.019
   Woodcock J, 2006, IUBMB LIFE, V58, P462, DOI 10.1080/15216540600871118
   Xia JY, 2015, CELL METAB, V22, P266, DOI 10.1016/j.cmet.2015.06.007
   Xia JY, 2014, BIOCHIMIE, V96, P130, DOI 10.1016/j.biochi.2013.08.013
   Xia WM, 2018, CELL REP, V23, P1948, DOI 10.1016/j.celrep.2018.04.055
   Xie C, 2017, DIABETES, V66, P613, DOI 10.2337/db16-0663
   Yamaji T, 2015, TRAFFIC, V16, P101, DOI 10.1111/tra.12239
   Yaribeygi H, 2020, DIABETIC MED, V37, P11, DOI 10.1111/dme.13943
   Yu CL, 2002, J BIOL CHEM, V277, P50230, DOI 10.1074/jbc.M200958200
   Yu JJ, 2015, CAN J CARDIOL, V31, P357, DOI 10.1016/j.cjca.2014.12.007
   Zhang Y, 2009, APOPTOSIS, V14, P878, DOI 10.1007/s10495-009-0364-4
   Zinda MJ, 2001, BIOCHEM BIOPH RES CO, V280, P1107, DOI 10.1006/bbrc.2000.4248
NR 107
TC 10
Z9 10
U1 2
U2 20
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0924-2244
EI 1879-3053
J9 TRENDS FOOD SCI TECH
JI Trends Food Sci. Technol.
PD MAY
PY 2021
VL 111
BP 483
EP 494
DI 10.1016/j.tifs.2021.03.010
EA MAR 2021
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA RN9XE
UT WOS:000640705100001
DA 2025-06-11
ER

PT J
AU Guo, ZJ
   Peng, YH
   Hu, QY
   Liu, N
   Liu, Q
AF Guo, Zhijiao
   Peng, Yanhui
   Hu, Qiaoyu
   Liu, Na
   Liu, Qing
TI The relationship between leptin and periodontitis: a literature review
SO PEERJ
LA English
DT Review
DE Leptin; Periodontitis; Mechanism; Inflammatory cytokines
ID SERUM LEPTIN; CIRCULATING LEPTIN; METABOLIC SYNDROME; OXIDATIVE STRESS;
   ASSOCIATION; ADIPONECTIN; LEVEL; INFLAMMATION; EXPRESSION; OBESITY
AB Leptin is a peptide hormone that regulates energy balance, immune inflammatory response, and bone metabolism. Several studies have demonstrated a relationship between leptin and periodontitis, a local inflammatory disease that progressively weakens the supporting structures of the teeth, eventually leading to tooth loss. This article reviews the existing literature and discusses leptin's basic characteristics, its relationship with periodontitis, and its effects on periodontal tissue metabolism.
C1 [Guo, Zhijiao; Peng, Yanhui; Hu, Qiaoyu; Liu, Qing] Hebei Med Univ, Sch & Hosp Stomatol, Hebei Clin Res Ctr Oral Dis, Hebei Key Lab Stomatol, Shijiazhuang, Hebei, Peoples R China.
   [Liu, Na] Hebei Med Univ, Sch & Hosp Stomatol, Dept Prevent Dent, Shijiazhuang, Hebei, Peoples R China.
C3 Hebei Medical University; Hebei Medical University
RP Liu, Q (corresponding author), Hebei Med Univ, Sch & Hosp Stomatol, Hebei Clin Res Ctr Oral Dis, Hebei Key Lab Stomatol, Shijiazhuang, Hebei, Peoples R China.; Liu, N (corresponding author), Hebei Med Univ, Sch & Hosp Stomatol, Dept Prevent Dent, Shijiazhuang, Hebei, Peoples R China.
EM ynlqdx@sina.com; kqliuqing@sina.com
CR Agrawal S, 2011, J CLIN IMMUNOL, V31, P89, DOI 10.1007/s10875-010-9456-8
   Ahuja CR, 2019, J INVESTIG CLIN DENT, V10, DOI 10.1111/jicd.12420
   Anton D, 2020, ROMANIAN J MED DENTA, V9, P57
   Bullon P, 2009, J DENT RES, V88, P503, DOI 10.1177/0022034509337479
   Chaves ID, 2022, J APPL ORAL SCI, V30, DOI 10.1590/1678-7757-2022-0238
   Chen MX, 2021, J CLIN PERIODONTOL, V48, P1165, DOI 10.1111/jcpe.13506
   Chen XX, 2015, J BONE MINER METAB, V33, P474, DOI 10.1007/s00774-014-0569-7
   Constantin A, 2010, J P ROMANIAN ACAD B, V1, P3
   Faienza MF, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00269
   Fentoglu Ozlem, 2008, Eur J Dent, V2, P142
   Finck BN, 2000, AM J PHYSIOL-REG I, V278, pR537, DOI 10.1152/ajpregu.2000.278.2.R537
   França LFC, 2017, J CLIN PERIODONTOL, V44, P568, DOI 10.1111/jcpe.12729
   Gan L, 2018, INT J OBESITY, V42, P252, DOI 10.1038/ijo.2017.208
   Ganesan SM, 2021, PERIODONTOL 2000, V87, P299, DOI 10.1111/prd.12390
   Gualillo O, 2000, LIFE SCI, V67, P2433, DOI 10.1016/S0024-3205(00)00827-4
   Guo YT, 2021, INT J MED SCI, V18, P2431, DOI 10.7150/ijms.56151
   Han Y, 2022, J DENT RES, V101, P675, DOI 10.1177/00220345211059418
   Hoffmann A, 2019, BIOFACTORS, V45, P43, DOI 10.1002/biof.1457
   Jepsen S, 2020, PERIODONTOL 2000, V83, P125, DOI 10.1111/prd.12326
   Johnson RB, 2001, J PERIODONTOL, V72, P1254, DOI 10.1902/jop.2000.72.9.1254
   Karpavicius A, 2012, WORLD J GASTROENTERO, V18, P6620, DOI 10.3748/wjg.v18.i45.6620
   Lai YR, 2020, J TRANSL MED, V18, DOI 10.1186/s12967-020-02559-7
   Landman RE, 2003, J CLIN ENDOCR METAB, V88, P1285, DOI 10.1210/jc.2002-021393
   Lee YH, 2016, Z RHEUMATOL, V75, P1021, DOI 10.1007/s00393-016-0050-1
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Li W, 2015, J PERIODONTOL, V86, P917, DOI 10.1902/jop.2015.150030
   Li ZC, 2023, J PERIODONTAL RES, V58, P392, DOI 10.1111/jre.13099
   Liberale L, 2017, CURR ATHEROSCLER REP, V19, DOI 10.1007/s11883-017-0644-3
   Listl S, 2015, J CLIN PERIODONTOL, V42, P470, DOI 10.1111/jcpe.12402
   Lord GM, 1998, NATURE, V394, P897, DOI 10.1038/29795
   Mattioli B, 2009, FEBS LETT, V583, P1102, DOI 10.1016/j.febslet.2009.02.029
   Meharwade VV, 2014, J PERIODONTAL IMPLAN, V44, P118, DOI 10.5051/jpis.2014.44.3.118
   Noack B, 2001, J PERIODONTOL, V72, P1221, DOI 10.1902/jop.2000.72.9.1221
   Obradovic M, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.585887
   Paunica I, 2023, DIAGNOSTICS, V13, DOI 10.3390/diagnostics13040681
   Purwar P, 2015, J PERIODONTOL, V86, P588, DOI 10.1902/jop.2014.140581
   Puurunen VP, 2017, ANN MED, V49, P448, DOI 10.1080/07853890.2017.1301678
   Reid IR, 2018, ENDOCR REV, V39, P938, DOI 10.1210/er.2017-00226
   Saito T, 2008, J DENT RES, V87, P319, DOI 10.1177/154405910808700416
   Sanz M, 2020, J CLIN PERIODONTOL, V47, P4, DOI 10.1111/jcpe.13290
   Scheja L, 2019, NAT REV ENDOCRINOL, V15, P507, DOI 10.1038/s41574-019-0230-6
   Selvarajan S, 2015, J CLIN DIAGN RES, V9, pZC48, DOI 10.7860/JCDR/2015/12335.5941
   Shimada Y, 2010, J PERIODONTOL, V81, P1118, DOI 10.1902/jop.2010.090741
   Shramko II, 2022, J DIABETES RES, V2022, DOI 10.1155/2022/9881422
   Soorya KV, 2014, J CLIN DIAGN RES, V8, DOI 10.7860/JCDR/2014/9490.5115
   Sun C, 2018, BIOSCIENCE REP, V38, DOI 10.1042/BSR20171214
   Thanakun S, 2017, ORAL DIS, V23, P956, DOI 10.1111/odi.12679
   Tian ZG, 2002, BIOCHEM BIOPH RES CO, V298, P297, DOI 10.1016/S0006-291X(02)02462-2
   Toy VE, 2023, CLIN ORAL INVEST, V27, P2763, DOI 10.1007/s00784-022-04854-7
   Tunes RS, 2010, J CAN DENT ASSOC, V76
   Wang TT, 2018, CYTOKINE GROWTH F R, V44, P38, DOI 10.1016/j.cytogfr.2018.10.002
   Wanichkittikul N, 2021, INT J DENT, V2021, DOI 10.1155/2021/6660097
   Williams RC, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0148024
   Yan L, 2022, J ORAL MED, V42, P58, DOI [10.13591/j.cnki.kqyx.2022.01.010, DOI 10.13591/J.CNKI.KQYX.2022.01.010]
   Yong JW, 2023, ORAL DIS, V29, P1172, DOI 10.1111/odi.14092
   Yu YY, 2019, J IMMUNOL, V202, P2728, DOI 10.4049/jimmunol.1801097
   Zarkesh-Esfahani H, 2004, J IMMUNOL, V172, P1809, DOI 10.4049/jimmunol.172.3.1809
   Zhang L, 2022, INT J OPHTHALMOL-CHI, V15, P554, DOI 10.18240/ijo.2022.04.05
   Zhang S N, 2020, Beijing Da Xue Xue Bao Yi Xue Ban, V53, P9
   ZHANG YY, 1994, NATURE, V372, P425, DOI 10.1038/372425a0
   Zhang ZY, 2021, FRONT CELL INFECT MI, V10, DOI 10.3389/fcimb.2020.585917
   Zhu JF, 2017, BMC ORAL HEALTH, V17, DOI 10.1186/s12903-017-0395-0
NR 62
TC 1
Z9 1
U1 1
U2 9
PU PEERJ INC
PI LONDON
PA 341-345 OLD ST, THIRD FLR, LONDON, EC1V 9LL, ENGLAND
SN 2167-8359
J9 PEERJ
JI PeerJ
PD DEC 15
PY 2023
VL 11
AR e16633
DI 10.7717/peerj.16633
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CR6Y6
UT WOS:001127021400003
PM 38111655
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhao, XJ
   Yang, YZ
   Zheng, YJ
   Wang, SC
   Gu, HM
   Pan, Y
   Wang, SJ
   Xu, HJ
   Kong, LD
AF Zhao, Xiao-Juan
   Yang, Yan-Zi
   Zheng, Yan-Jing
   Wang, Shan-Chun
   Gu, Hong-Mei
   Pan, Ying
   Wang, Shui-Juan
   Xu, Hong-Jiang
   Kong, Ling-Dong
TI Magnesium isoglycyrrhizinate blocks fructose-induced hepatic NF-κB/NLRP3
   inflammasome activation and lipid metabolism disorder
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Magnesium isoglycyrrhizinate; Fructose-induced metabolic syndrome; Liver
   injury; Immunological-inflammatory and metabolic; profile; NF-kappa
   B/NLRP3 inflammasome activation
ID ACCUMULATION; SUPPLEMENTATION; PATHWAYS; OBESITY; STRESS; CELLS
AB Magnesium isoglycyrrhizinate as a hepatoprotective agent possesses immune modulation and anti-inflammation, and treats liver diseases. But its effects on immunological-inflammatory and metabolic profiles for metabolic syndrome with liver injury and underlying potential mechanisms are not fully understood. In this study, magnesium isoglycyrrhizinate alleviated liver inflammation and lipid accumulation in fructose-fed rats with metabolic syndrome. It also suppressed hepatic inflammatory signaling activation by reducing protein levels of phosphorylation of nuclear factor-kappa B p65 (p-NF-kappa B p65), inhibitor of nuclear factor kappa-B kinase alpha/beta (p-IKK alpha/beta) and inhibitor of NF-kappa B alpha (p-I kappa B alpha) as well as nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3), apoptosis-associated speck-like protein (ASC) and Caspase-1 in rats, being consistent with its reduction of interleulan-1 beta (IL-1 beta, tumor necrosis factor-a (TNF-alpha) and IL-6 levels. Furthermore, magnesium isoglycyrrhizinate modulated lipid metabolism-related genes characterized by up-regulating peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and carnitine palmitoyl transferase-1 (CPT-1), and down-regulating sensor for fatty acids to control-1 (SREBP-1) and stearoyl-CoA desaturase 1 (SCD-1) in the liver of fructose-fed rats, resulting in the reduction of triglyceride and total cholesterol levels. These effective actions were further confirmed in fructose-exposed BRL-3A and HepG2 cells. The molecular mechanisms underpinning these observations suggest that magnesium isoglycyrrhizinate may inhibit NF-kappa B/NLRP3 inflammasome activation to reduce immunological-inflammatory response, which in turn may prevent liver lipid metabolic disorder and accumulation under high fructose condition. Thus, blockade of NF-kappa B/NLRP3 inflammasome activation and lipid metabolism disorder by magnesium isoglycyrrhizinate may be the potential therapeutic approach for improving fructose-induced liver injury with metabolic syndrome in clinic.
C1 [Zhao, Xiao-Juan; Yang, Yan-Zi; Zheng, Yan-Jing; Pan, Ying; Wang, Shui-Juan; Kong, Ling-Dong] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China.
   [Wang, Shan-Chun; Gu, Hong-Mei; Xu, Hong-Jiang] Chia Tai Tianqing Pharmaceut Grp Co LTD, Drug Screening & Evaluat Dept R&D Inst, Nanjing 210023, Jiangsu, Peoples R China.
C3 Nanjing University
RP Kong, LD (corresponding author), Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China.; Xu, HJ (corresponding author), Chia Tai Tianqing Pharmaceut Grp Co LTD, Drug Screening & Evaluat Dept R&D Inst, Nanjing 210023, Jiangsu, Peoples R China.
EM 13915987463@163.com; kongld@nju.edu.cn
FU Natural Science Foundation of Jiangsu Province [BK20141243]
FX This work was supported by Natural Science Foundation of Jiangsu
   Province (Grant No. BK20141243).
CR Cheng Y, 2009, PHARMACOLOGY, V84, P183, DOI 10.1159/000235873
   Chi X. H., 2010, CHIN J DRUG APPL MON, V7, P279
   Fan CY, 2014, J NUTR BIOCHEM, V25, P353, DOI 10.1016/j.jnutbio.2013.11.010
   Han X, 2016, CHEM-BIOL INTERACT, V257, P132, DOI 10.1016/j.cbi.2016.08.002
   He YQ, 2010, J BIOMED RES, V24, P153, DOI 10.1016/S1674-8301(10)60024-3
   Henao-Mejia J, 2012, NATURE, V482, P179, DOI 10.1038/nature10809
   Huang XL, 2014, INT J CLIN EXP PATHO, V7, P4755
   Incir S, 2016, LIFE SCI, V158, P57, DOI 10.1016/j.lfs.2016.06.014
   JIN Juan, 2009, Zhonghua Gan Zang Bing Za Zhi, V17, P389
   Khitan Z, 2013, J NUTR METAB, V2013, DOI 10.1155/2013/682673
   Lee HM, 2013, DIABETES, V62, P194, DOI 10.2337/db12-0420
   Li JM, 2010, HEPATOLOGY, V51, P1555, DOI 10.1002/hep.23524
   Li L, 2014, FOOD CHEM TOXICOL, V63, P166, DOI 10.1016/j.fct.2013.08.036
   Li S. L., 2014, CHIN J COAL IND MED, V17, P368
   Li YanLi Li YanLi, 2011, Practical Pharmacy and Clinical Remedies, V14, P521
   [林睿 Lin Rui], 2014, [上海交通大学学报. 医学版, Journal of Shanghai Jiaotong University .Medical Science], V34, P1132
   Ma KL, 2008, HEPATOLOGY, V48, P770, DOI 10.1002/hep.22423
   Moschen AR, 2011, MOL MED, V17, P840, DOI 10.2119/molmed.2010.00108
   Nagai Y, 2002, AM J PHYSIOL-ENDOC M, V282, pE1180, DOI 10.1152/ajpendo.00471.2001
   Nigro D, 2017, J NUTR BIOCHEM, V42, P160, DOI 10.1016/j.jnutbio.2017.01.010
   Rodríguez-Calvo R, 2009, HEPATOLOGY, V49, P106, DOI 10.1002/hep.22570
   Stienstra R, 2011, P NATL ACAD SCI USA, V108, P15324, DOI 10.1073/pnas.1100255108
   Tang GH, 2015, WORLD J GASTROENTERO, V21, P12370, DOI 10.3748/wjg.v21.i43.12370
   Vos MB, 2013, HEPATOLOGY, V57, P2525, DOI 10.1002/hep.26299
   [王佩 Wang Pei], 2004, [中国新药与临床杂志, Chinese Journal of New Drugs and Clinical Remedies], V23, P833
   Wang X, 2013, BIOCHEM PHARMACOL, V86, P1791, DOI 10.1016/j.bcp.2013.10.005
   Xu Q, 2016, INT J MOL MED, V38, P275, DOI 10.3892/ijmm.2016.2603
   Yan Yulan, 2015, Zhonghua Gan Zang Bing Za Zhi, V23, P204, DOI 10.3760/cma.j.issn.1007-3418.2015.03.010
   Yang Q, 2016, DRUG DES DEV THER, V10, P443, DOI 10.2147/DDDT.S92440
   Yki-Järvinen H, 2014, LANCET DIABETES ENDO, V2, P901, DOI 10.1016/S2213-8587(14)70032-4
   Zeng C. X., 2006, J CHINA PHARM, V20, P1543
   Zhang Jin-chi, 2012, Zhonghua Gan Zang Bing Za Zhi, V20, P537, DOI 10.3760/cma.j.issn.1007-3418.2012.07.012
   Zhang X, 2015, ANTIOXID REDOX SIGN, V22, P848, DOI 10.1089/ars.2014.5868
   Zhou GY, 2016, BIOMED PHARMACOTHER, V81, P318, DOI 10.1016/j.biopha.2016.04.013
NR 34
TC 59
Z9 62
U1 1
U2 51
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD AUG 15
PY 2017
VL 809
BP 141
EP 150
DI 10.1016/j.ejphar.2017.05.032
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EZ9JU
UT WOS:000405047400016
PM 28526339
DA 2025-06-11
ER

PT J
AU Saraf, R
   Huang, T
   Mahmood, F
   Owais, K
   Bardia, A
   Khabbaz, KR
   Liu, D
   Senthilnathan, V
   Lassaletta, AD
   Sellke, F
   Matyal, R
AF Saraf, Rabya
   Huang, Thomas
   Mahmood, Feroze
   Owais, Khurram
   Bardia, Amit
   Khabbaz, Kamal R.
   Liu, David
   Senthilnathan, Venkatachalam
   Lassaletta, Antonio D.
   Sellke, Frank
   Matyal, Robina
TI Early Cellular Changes in the Ascending Aorta and Myocardium in a Swine
   Model of Metabolic Syndrome
SO PLOS ONE
LA English
DT Article
ID ARTERIAL STIFFNESS; OXIDATIVE STRESS; NEUROPEPTIDE-Y; NITRIC-OXIDE;
   HYPERTENSION; APOPTOSIS; INFLAMMATION; MECHANISMS; PRESSURE; FIBROSIS
AB Background
   Metabolic syndrome is associated with pathological remodeling of the heart and adjacent vessels. The early biochemical and cellular changes underlying the vascular damage are not fully understood. In this study, we sought to establish the nature, extent, and initial time-line of cytochemical derangements underlying reduced ventriculo-arterial compliance in a swine model of metabolic syndrome.
   Methods
   Yorkshire swine (n = 8 per group) were fed a normal diet (ND) or a high-cholesterol (HCD) for 12 weeks. Myocardial function and blood flow was assessed before harvesting the heart. Immuno-blotting and immuno-histochemical staining were used to assess the cellular changes in the myocardium, ascending aorta and left anterior descending artery (LAD).
   Results
   There was significant increase in body mass index, blood glucose and mean arterial pressures (p = 0.002, p = 0.001 and p = 0.024 respectively) in HCD group. At the cellular level there was significant increase in anti-apoptotic factors p-Akt (p = 0.007 and p = 0.002) and Bcl-xL (p = 0.05 and p = 0.01) in the HCD aorta and myocardium, respectively. Pro-fibrotic markers TGF-beta (p = 0.01), pSmad1/5 (p = 0.03) and MMP-9 (p = 0.005) were significantly increased in the HCD aorta. The levels of pro-apoptotic p38MAPK, Apaf-1 and cleaved Caspase3 were significantly increased in aorta of HCD (p = 0.03, p = 0.04 and p = 0.007 respectively). Similar changes in coronary arteries were not observed in either group. Functionally, the high cholesterol diet resulted in significant increase in ventricular end systolic pressure and-dp/dt (p = 0.05 and p = 0.007 respectively) in the HCD group.
   Conclusion
   Preclinical metabolic syndrome initiates pro-apoptosis and pro-fibrosis pathways in the heart and ascending aorta, while sparing coronary arteries at this early stage of dietary modification.
C1 [Saraf, Rabya; Khabbaz, Kamal R.; Liu, David; Senthilnathan, Venkatachalam; Lassaletta, Antonio D.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Surg,Div Cardiac Surg, Boston, MA 02215 USA.
   [Huang, Thomas; Mahmood, Feroze; Owais, Khurram; Bardia, Amit; Matyal, Robina] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02215 USA.
   [Lassaletta, Antonio D.; Sellke, Frank] Rhode Isl Hosp, Brown Alpert Sch Med, Dept Surg, Providence, RI USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Beth Israel Deaconess Medical Center; Harvard University;
   Harvard Medical School; Harvard University Medical Affiliates; Beth
   Israel Deaconess Medical Center; Lifespan Health Rhode Island; Rhode
   Island Hospital; Brown University
RP Matyal, R (corresponding author), Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02215 USA.
EM rmatyal1@bidmc.harvard.edu
RI Liu, David R./HCH-3132-2022; Mahmood, Feroze/B-1383-2008
OI Huang, Thomas/0000-0001-7257-1134
FU Department of Anesthesia at Beth Israel Deaconess Medical Center; Ronald
   M. Weintraub Family Research Fund; NIH [R01 HL069024, RO1 HL46716]
FX This research was supported by the Department of Anesthesia at Beth
   Israel Deaconess Medical Center, the Ronald M. Weintraub Family Research
   Fund, and NIH grants R01 HL069024 and RO1 HL46716. The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
CR Akhtar S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039066
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Asbun J, 2006, J AM COLL CARDIOL, V47, P693, DOI 10.1016/j.jacc.2005.09.050
   Asrih M, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/370715
   Battiprolu P.K., 2010, DRUG DISCOV TODAY DI, V7, pe135, DOI DOI 10.1016/J.DDMEC.2010.08.001
   BAUMGARTNERPARZER SM, 1995, DIABETES, V44, P1323, DOI 10.2337/diabetes.44.11.1323
   Cai H, 2000, CIRC RES, V87, P840, DOI 10.1161/01.RES.87.10.840
   Czernichow S, 2005, AM J HYPERTENS, V18, P1154, DOI 10.1016/j.amjhyper.2005.04.006
   Dart AM, 2001, J AM COLL CARDIOL, V37, P975, DOI 10.1016/S0735-1097(01)01108-1
   Dhalla NS, 2000, J HYPERTENS, V18, P655, DOI 10.1097/00004872-200018060-00002
   Dikalov SI, 2013, AM J PHYSIOL-HEART C, V305, pH1417, DOI 10.1152/ajpheart.00089.2013
   Ghigliotti G, 2014, INFLAMMATION, V37, P1337, DOI 10.1007/s10753-014-9914-1
   Giacco F, 2010, CIRC RES, V107, P1058, DOI 10.1161/CIRCRESAHA.110.223545
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Hamasaki S, 2000, J AM COLL CARDIOL, V35, P1654, DOI 10.1016/S0735-1097(00)00594-5
   Hay I, 2005, AM J PHYSIOL-HEART C, V288, pH1203, DOI 10.1152/ajpheart.00681.2004
   Henry RMA, 2003, CIRCULATION, V107, P2089, DOI 10.1161/01.CIR.0000065222.34933.FC
   Intengan HD, 2001, HYPERTENSION, V38, P581, DOI 10.1161/hy09t1.096249
   Jain S, 2014, ATHEROSCLEROSIS, V237, P381, DOI 10.1016/j.atherosclerosis.2014.09.011
   Kangas P, 2013, METABOLISM, V62, P1114, DOI 10.1016/j.metabol.2013.02.009
   Kilkenny C, 2010, PLOS BIOL, V8, DOI 10.1371/journal.pbio.1000412
   Laursen JB, 2001, FREE RADICAL RES, V35, P387, DOI 10.1080/10715760100300901
   Li HG, 2014, ATHEROSCLEROSIS, V237, P208, DOI 10.1016/j.atherosclerosis.2014.09.001
   MARIN J, 1995, MECH AGEING DEV, V79, P71, DOI 10.1016/0047-6374(94)01551-V
   Matsuzawa Y, 2004, ARTERIOSCL THROM VAS, V24, P29, DOI 10.1161/01.ATV.0000099786.99623.EF
   Mattace-Raso FUS, 2006, CIRCULATION, V113, P657, DOI 10.1161/CIRCULATIONAHA.105.555235
   Matyal R, 2013, EUR J PHARMACOL, V718, P261, DOI 10.1016/j.ejphar.2013.08.023
   Matyal R, 2011, EUR J PHARMACOL, V665, P19, DOI 10.1016/j.ejphar.2011.04.039
   RAMSEY MW, 1995, CIRCULATION, V92, P3212, DOI 10.1161/01.CIR.92.11.3212
   Robich MP, 2011, EUR J PHARMACOL, V664, P45, DOI 10.1016/j.ejphar.2011.04.059
   Robich MP, 2010, J MOL CELL CARDIOL, V49, P1022, DOI 10.1016/j.yjmcc.2010.08.022
   Rose BA, 2010, PHYSIOL REV, V90, P1507, DOI 10.1152/physrev.00054.2009
   Safar ME, 2006, J AM COLL CARDIOL, V47, P72, DOI 10.1016/j.jacc.2005.08.052
   Schillaci G, 2005, HYPERTENSION, V45, P1078, DOI 10.1161/01.HYP.0000165313.84007.7d
   Singleton JR, 2003, DIABETES, V52, P2867, DOI 10.2337/diabetes.52.12.2867
   Spitler KM, 2014, HYPERTENSION, V63, pE40, DOI 10.1161/HYPERTENSIONAHA.113.02558
   Trask AJ, 2012, J APPL PHYSIOL, V113, P1128, DOI 10.1152/japplphysiol.00604.2012
   UUSITUPA MIJ, 1990, ANN MED, V22, P377, DOI 10.3109/07853899009147274
   Walldius G, 2004, CLIN CHEM LAB MED, V42, P1355, DOI 10.1515/CCLM.2004.254
   Walsh K, 2006, CIRCULATION, V113, P2032, DOI 10.1161/CIRCULATIONAHA.106.615138
   Wang MY, 2006, ARTERIOSCL THROM VAS, V26, P1503, DOI 10.1161/01.ATV.0000225777.58488.f2
   Wang WS, 2005, NEPHROLOGY, V10, P48, DOI 10.1111/j.1440-1797.2005.00334.x
   Yiu KH, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-94
   Zieman SJ, 2005, ARTERIOSCL THROM VAS, V25, P932, DOI 10.1161/01.ATV.0000160548.78317.29
NR 44
TC 5
Z9 5
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 14
PY 2016
VL 11
IS 1
AR e0146481
DI 10.1371/journal.pone.0146481
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DB4CC
UT WOS:000368459300022
PM 26766185
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Kang, YH
   Min, HK
   Son, SM
   Kim, IJ
   Kim, YK
AF Kang, Yang Ho
   Min, Hong Ki
   Son, Seok Man
   Kim, In Ju
   Kim, Yong Ki
TI The association of serum gamma glutamyltransferase with components of
   the metabolic syndrome in the Korean adults
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE gamma glutamyltransferase; metabolic syndrome; insulin resistance;
   HOMA-IR
ID AGED JAPANESE MEN; BLOOD-CELL COUNT; GLUTAMYL-TRANSFERASE; INSULIN
   RESISTANCE; HEART-DISEASE; RISK-FACTORS; TRANSPEPTIDASE
AB The metabolic syndrome (MS) is a cluster of risk factors for cardiovascular disease related to insulin resistance. Recently, serum gamma glutamyltransferase (GGT) has been proposed as a marker of oxidative stress and is associated with a marked increase in the risk of cardiovascular disease. So, we investigated the association between serum GGT and components of the metabolic syndrome in the Korean adults.
   A total 3246 adults (aged 20-70 years, 1622 men and 1624 women) who visited Center for Health Promotion in Pusan National University Hospital for a medical checkup were included. We measured serum GGT and lipid profiles, fasting glucose, fasting insulin and blood pressure.
   As the quartile of serum GGT increased, the number of components of MS and prevalence of MS were increased. Serum GGT was also increased according as the number of components of MS was increased. A significant correlation (r = 0.200, p < 0.001 in men and r = 0.133, p < 0.001 in women) was noted between the numbers of the components of the MS and serum GGT. In addition, serum GGT was correlated significantly (r = 0.266, p < 0.001 in men and r = 0.264, p < 0.001 in women) with homeostasis model assessment of insulin resistance (HOMA-IR). In linear regression model, serum GGT was mainly influenced by the concentration of triglycerides and fasting glucose.
   In conclusion, serum GGT is closely related with insulin resistance and the increased number of components of MS. Among components of MS, serum GGT may be more associated with dyslipidemia and abnormal glucose tolerance, suggesting that serum GGT has more relationship with hepatic insulin resistance regardless of non-alcoholic fatty liver disease. (C) 2007 Published by Elsevier Ireland Ltd.
C1 Pusan Natl Univ, Sch Med, Dept Internal Med, Pusan 602739, South Korea.
   Pusan Natl Univ, Sch Med, Dept Family Med, Pusan 602739, South Korea.
C3 Pusan National University; Pusan National University Hospital; Pusan
   National University; Pusan National University Hospital
RP Son, SM (corresponding author), Pusan Natl Univ, Sch Med, Dept Internal Med, 1-10 Ami Dong, Pusan 602739, South Korea.
EM somsm@pusan.ac.kr
RI Min, Hong Ki/HLX-4792-2023; Kim, In-Ju/S-6408-2017; Kang, Yang
   Ho/C-7296-2018
OI Min, Hong Ki/0000-0003-1147-1046; Kang, Yang Ho/0000-0002-1215-7975
CR BOTS ML, 2002, COMMUNITY HLTH S1, V56, P125
   CAROL AM, 1992, GEN ULTRASOUND, P184
   FACCHINI F, 1992, J INTERN MED, V232, P267, DOI 10.1111/j.1365-2796.1992.tb00582.x
   Ferroni Patrizia, 2004, Curr Atheroscler Rep, V6, P424, DOI 10.1007/s11883-004-0082-x
   JACOBS DR, 2001, JAMA-J AM MED ASSOC, V285, P2486
   KANNEL WB, 1992, JAMA-J AM MED ASSOC, V267, P1253, DOI 10.1001/jama.267.9.1253
   Kim DJ, 2005, DIABETIC MED, V22, P1134, DOI 10.1111/j.1464-5491.2005.01581.x
   Lee DH, 2005, ATHEROSCLEROSIS, V178, P327, DOI 10.1016/j.atherosclerosis.2004.08.027
   Lee DH, 2004, FREE RADICAL RES, V38, P535, DOI 10.1080/10715760410001694026
   Lee DH, 2003, CLIN CHEM, V49, P1358, DOI 10.1373/49.8.1358
   Lee DH, 2003, DIABETOLOGIA, V46, P359, DOI 10.1007/s00125-003-1036-5
   Marchesini G, 2001, DIABETES, V50, P1844, DOI 10.2337/diabetes.50.8.1844
   Nakanishi N, 2004, DIABETES CARE, V27, P1427, DOI 10.2337/diacare.27.6.1427
   Nakanishi N, 2003, J INTERN MED, V254, P287, DOI 10.1046/j.1365-2796.2003.01198.x
   NEMESANSZKY E, 1985, CLIN CHEM, V31, P797
   Nissen O, 1990, AM J EPIDEMIOL, V132, P318
   Perry IJ, 1998, DIABETES CARE, V21, P732, DOI 10.2337/diacare.21.5.732
   Rantala AO, 2000, J INTERN MED, V248, P230, DOI 10.1046/j.1365-2796.2000.00723.x
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Sakugawa H, 2004, WORLD J GASTROENTERO, V10, P1052
   Sonnenberg GE, 2004, OBES RES, V12, P180, DOI 10.1038/oby.2004.24
   STARK AA, 1991, MUTAGENESIS, V6, P241, DOI 10.1093/mutage/6.4.241
   TESCHKE R, 1977, BIOCHEM BIOPH RES CO, V75, P718, DOI 10.1016/0006-291X(77)91531-5
   Thamer C, 2005, HORM METAB RES, V37, P246, DOI 10.1055/s-2005-861411
   WANNAMETHEE G, 1995, AM J EPIDEMIOL, V142, P699, DOI 10.1093/oxfordjournals.aje.a117699
   Wannamethee SG, 2005, DIABETES CARE, V28, P2913, DOI 10.2337/diacare.28.12.2913
   Whitfield JB, 2001, CRIT REV CL LAB SCI, V38, P263, DOI 10.1080/20014091084227
   World Health Organization, 2000, AS PAC PERSP REF OB
NR 28
TC 53
Z9 54
U1 0
U2 0
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD AUG
PY 2007
VL 77
IS 2
BP 306
EP 313
DI 10.1016/j.diabres.2006.11.009
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 174EM
UT WOS:000246924100023
PM 17353063
DA 2025-06-11
ER

PT J
AU Urwyler, SA
   Schuetz, P
   Ebrahimi, F
   Donath, MY
   Christ-Crain, M
AF Urwyler, Sandrine Andrea
   Schuetz, Philipp
   Ebrahimi, Fahim
   Donath, Marc Y.
   Christ-Crain, Mirjam
TI Interleukin-1 Antagonism Decreases Cortisol Levels in Obese Individuals
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; PHASE-I TRIAL; METABOLIC SYNDROME; WEIGHT-LOSS;
   CYTOKINES; RELEASE; INFLAMMATION; IL-1-BETA; HORMONES; STRESS
AB Context: Increased cortisol levels in obesity may contribute to the associated metabolic syndrome. In obesity, the activated innate immune system leads to increased interleukin (IL)-1 beta, which is known to stimulate the release of adrenocorticotropin hormone (ACTH).
   Objectives: We hypothesized that in obesity IL-1 antagonism would result in downregulation of the hypothalamo-pituitary-adrenal axis, leading to decreased cortisol levels.
   Design and Participants: In this prospective intervention study, we included 73 patients with obesity (body mass index [BMI] >= 30 kg/m(2)) and at least one additional feature of the metabolic syndrome.
   Outcome Measures: The primary end point was change in morning cortisol from baseline to after the administration of the IL-1 receptor antagonist (anakinra/Kineret (R), total dose 3 x 100 mg). Secondary end points were effects on salivary cortisol and ACTH.
   Results: Median age was 56 years, 50.7% of patients were female, and median BMI was 36.3 kg/m(2). Median morning serum cortisol levels (nmol/L) decreased significantly after IL-1 antagonism [from baseline, 452 to 423; absolute difference, -38.7; 95% confidence interval (CI), -64 to -13.4; P = 0.0019]. Similar effects were found for salivary cortisol levels (-2.8; 95% CI, -4.4 to -1.3; P = 0.0007), ACTH levels (-2.2; 95% CI; -4.2 to -0.1; P = 0.038), systolic blood pressure (-5.2, 95% CI, -8.5 to -1.8; P = 0.0006), and heart rate (-2.9; 95% CI,-4.7 to -1.0; P = 0.0029).
   Conclusion: IL-1 antagonism in obese individuals with features of the metabolic syndrome leads to a decrease in serum cortisol, salivary cortisol, and ACTH levels along with a reduction in systolic blood pressure and heart rate.
C1 [Urwyler, Sandrine Andrea; Ebrahimi, Fahim; Donath, Marc Y.; Christ-Crain, Mirjam] Univ Basel Hosp, Dept Endocrinol Diabetol & Metab, CH-4031 Basel, Switzerland.
   [Urwyler, Sandrine Andrea; Schuetz, Philipp; Ebrahimi, Fahim; Donath, Marc Y.; Christ-Crain, Mirjam] Univ Basel Hosp, Dept Clin Res, CH-4031 Basel, Switzerland.
   [Schuetz, Philipp] Kantonsspital Aarau, Dept Endocrinol, Med Univ Clin, CH-5001 Aarau, Switzerland.
C3 University of Basel; University of Basel; Kantonsspital Aarau AG (KSA)
RP Urwyler, SA (corresponding author), Univ Hosp, Petersgraben 4, CH-4031 Basel, Switzerland.
EM sandrine.urwyler@usb.ch
RI Ebrahimi, Fahim/JQI-5819-2023; Schuetz, Philipp/C-8475-2013
OI Christ-Crain, Mirjam/0000-0002-6336-0965; Schuetz,
   Philipp/0000-0001-6400-4949; Urwyler, Sandrine
   Andrea/0000-0003-4056-2262; Ebrahimi, Fahim/0000-0001-5862-966X
FU Swiss National Foundation [PP00P3-12346]; University Hospital Basel;
   University of Basel
FX This work was supported by the Swiss National Foundation (Grant no.
   PP00P3-12346) (to M.C.-C.), the "Wissenschaftspool 2014" of the
   University Hospital Basel (to S.A.U.), and the University of Basel
   (Nachwuchsforderung 2015) (to S.A.U.). The funding sources were neither
   involved in the design of the study nor in writing of the manuscript.
   The authors have no conflicts of interest to declare.
CR Abraham SB, 2013, OBESITY, V21, pE105, DOI 10.1002/oby.20083
   An K, 2016, BIOL RES NURS, V18, P241, DOI 10.1177/1099800415604437
   Anagnostis P, 2009, J CLIN ENDOCR METAB, V94, P2692, DOI 10.1210/jc.2009-0370
   Ballak DB, 2015, CYTOKINE, V75, P280, DOI 10.1016/j.cyto.2015.05.005
   Bedi O, 2016, N-S ARCH PHARMACOL, V389, P695, DOI 10.1007/s00210-016-1252-4
   BERNTON EW, 1987, SCIENCE, V238, P519, DOI 10.1126/science.2821620
   Besedovsky HO, 1996, ENDOCR REV, V17, P64, DOI 10.1210/edrv-17-1-64
   Chae JS, 2013, NUTR RES, V33, P195, DOI 10.1016/j.nutres.2013.01.005
   Cottam DR, 2004, OBES SURG, V14, P589, DOI 10.1381/096089204323093345
   CROWN J, 1991, BLOOD, V78, P1420
   Curti BD, 1996, J IMMUNOTHER, V19, P142, DOI 10.1097/00002371-199603000-00007
   Dalmas E, 2011, AM J CLIN NUTR, V94, P450, DOI 10.3945/ajcn.111.013771
   Di Renzo L, 2007, PHARMACOL RES, V55, P131, DOI 10.1016/j.phrs.2006.11.002
   Donath MY, 2014, NAT REV DRUG DISCOV, V13, P465, DOI 10.1038/nrd4275
   Donath MY, 2013, CELL METAB, V17, P860, DOI 10.1016/j.cmet.2013.05.001
   Donath MY, 2011, NAT REV IMMUNOL, V11, P98, DOI 10.1038/nri2925
   DUNKELMAN SS, 1964, J CLIN ENDOCR METAB, V24, P832, DOI 10.1210/jcem-24-9-832
   Flegal KM, 2007, JAMA-J AM MED ASSOC, V298, P2028, DOI 10.1001/jama.298.17.2028
   Goshen I, 2009, FRONT NEUROENDOCRIN, V30, P30, DOI 10.1016/j.yfrne.2008.10.001
   JONES TH, 1993, CYTOKINE, V5, P531, DOI 10.1016/S1043-4666(05)80001-8
   Larsen CM, 2007, NEW ENGL J MED, V356, P1517, DOI 10.1056/NEJMoa065213
   Manenschijn L, 2013, J CLIN ENDOCR METAB, V98, P2078, DOI 10.1210/jc.2012-3663
   MARIN P, 1992, METABOLISM, V41, P882, DOI 10.1016/0026-0495(92)90171-6
   McCann SM, 2000, ANN NY ACAD SCI, V917, P4, DOI 10.1111/j.1749-6632.2000.tb05368.x
   Müssig K, 2010, J STEROID BIOCHEM, V121, P589, DOI 10.1016/j.jsbmb.2010.01.008
   NAVARRA P, 1991, ENDOCRINOLOGY, V128, P37, DOI 10.1210/endo-128-1-37
   Neary NM, 2013, J CLIN ENDOCR METAB, V98, P2045, DOI 10.1210/jc.2012-3754
   Pasquali R, 2006, ANN NY ACAD SCI, V1083, P111, DOI 10.1196/annals.1367.009
   Reinehr T, 2014, J CLIN ENDOCR METAB, V99, P2391, DOI 10.1210/jc.2013-4398
   Ridker PM, 2011, AM HEART J, V162, P597, DOI 10.1016/j.ahj.2011.06.012
   Sapolsky RM, 2000, ENDOCR REV, V21, P55, DOI 10.1210/er.21.1.55
   Turnbull AV, 1999, PHYSIOL REV, V79, P1, DOI 10.1152/physrev.1999.79.1.1
   vanderMeer MJM, 1996, J ENDOCRINOL INVEST, V19, P175, DOI 10.1007/BF03349862
   WOLOSKI BMRNJ, 1985, SCIENCE, V230, P1035, DOI 10.1126/science.2997929
   YASIN S, 1994, NEUROENDOCRINOLOGY, V60, P553, DOI 10.1159/000126796
   Zhang JD, 2016, CELL METAB, V23, P360, DOI 10.1016/j.cmet.2015.11.013
NR 36
TC 18
Z9 19
U1 0
U2 6
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD MAY 1
PY 2017
VL 102
IS 5
BP 1712
EP 1718
DI 10.1210/jc.2016-3931
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EW6IX
UT WOS:000402614700033
PM 28324042
OA Green Published, Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Bogh, HL
   Stanislaus, S
   Kjærstad, HL
   Sletved, KSO
   Forman, JL
   Poulsen, HE
   Vinberg, M
   Kessing, LV
   Coello, K
AF Bogh, Helena Lykke
   Stanislaus, Sharleny
   Kjaerstad, Hanne Lie
   Sletved, Kimie Stefanie Ormstrup
   Forman, Julie Lyng
   Poulsen, Henrik Enghusen
   Vinberg, Maj
   Kessing, Lars Vedel
   Coello, Klara
TI Associations between levels of oxidative nucleoside damage and
   cardiovascular risk in patients newly diagnosed with bipolar disorder
   and their unaffected relatives
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
ID SUBCLINICAL ATHEROSCLEROSIS; STRESS MARKERS; GENERATED DNA;
   RATING-SCALE; RNA DAMAGE; DISEASE; PREVALENCE;
   8-OXO-7,8-DIHYDRO-2'-DEOXYGUANOSINE; METAANALYSIS; RELIABILITY
AB Enhanced oxidative stress-generated nucleoside damage may contribute to the increased cardiovascular disease mortality in patients with bipolar disorder (BD) but the association has never been investigated. We investigated the associations between oxidative stress-generated damage to DNA (8-oxodG) and RNA (8-oxoGuo), respectively, and three measures reflecting cardiovascular risk; namely, the Framingham 30-year risk score of cardiovascular diseases, the metabolic syndrome, and the insulin resistance index in 360 patients newly diagnosed with BD, 102 of their unaffected relatives (UR) and 197 healthy control individuals (HC). In sex- and age-adjusted models, the 30-year cardiovascular risk score increased by 20.8% (CI = 7.4-35.9%, p = 0.002) for every one nM/mM creatinine increase in 8-oxoGuo and by 15.6% (95% CI = 5.8-26.4%, p = 0.001) for every one nM/mM creatinine increase in 8-oxodG, respectively. Further, insulin resistance index increased by 24.1% (95% CI = 6.7-43%, p = 0.005) when 8-oxoGuo increased one nM/mM creatinine. The associations between cardiovascular measures and oxidative nucleoside damage were more pronounced in patients with BD compared with UR, and HC. Metabolic syndrome was not associated with nucleoside damage. Overall, higher oxidative stress-generated nucleoside damage was associated with a higher cardiovascular risk score and a higher degree of insulin resistance index, and having BD impacted the associations. Further, within patients, treatment with psychotropics seemed to enhance the associations between 30-year CVD risk score and insulin resistance index, respectively, and oxidatively stress-generated nucleoside damage. Our findings support enhanced oxidative stress-generated nucleoside damage as a putative pathophysiological mechanism that may mediate the higher cardiovascular risk observed in patients with BD already at the time of diagnosis.
C1 [Bogh, Helena Lykke; Stanislaus, Sharleny; Kjaerstad, Hanne Lie; Sletved, Kimie Stefanie Ormstrup; Vinberg, Maj; Kessing, Lars Vedel; Coello, Klara] Copenhagen Univ Hosp, Copenhagen Affect Disorders Res Ctr CADIC, Psychiat Ctr Copenhagen, Rigshosp, Copenhagen, Denmark.
   [Bogh, Helena Lykke; Sletved, Kimie Stefanie Ormstrup; Poulsen, Henrik Enghusen; Vinberg, Maj; Kessing, Lars Vedel] Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark.
   [Forman, Julie Lyng] Univ Copenhagen, Dept Publ Hlth, Sect Biostat, Copenhagen, Denmark.
   [Poulsen, Henrik Enghusen] Copenhagen Univ Hosp Bispebjerg Frederiksberg, Dept Endocrinol, Frederiksberg, Denmark.
   [Poulsen, Henrik Enghusen] Copenhagen Univ Hosp North Zealand, Dept Cardiol, Hillerod, Denmark.
   [Poulsen, Henrik Enghusen] North Zealand Hosp Hillerd, Res Unit, Hillerod, Denmark.
   [Vinberg, Maj] Copenhagen Univ Hosp, Psychiat Ctr North Zealand, Psychiat Res Unit, Hillerod, Denmark.
C3 University of Copenhagen; Copenhagen University Hospital;
   Rigshospitalet; University of Copenhagen; University of Copenhagen;
   University of Copenhagen; Bispebjerg Hospital; University of Copenhagen;
   Copenhagen University Hospital
RP Coello, K (corresponding author), Copenhagen Univ Hosp, Copenhagen Affect Disorders Res Ctr CADIC, Psychiat Ctr Copenhagen, Rigshosp, Copenhagen, Denmark.
EM klara.coello@regionh.dk
RI Coello, Klara/AAZ-6545-2020; Kessing, Lars/JNS-2493-2023;
   Vinberg/ABC-7493-2021; Kjærstad, Hanne/IWD-9362-2023
OI Forman, Julie/0000-0001-7368-0869; Coello, Klara/0000-0003-1568-2991;
   Vinberg, Maj/0000-0002-5982-1335; Kessing, Lars/0000-0001-9377-9436;
   Kjaerstad, Hanne Lie/0000-0001-7781-8853
FU Mental Health Services, Capital Region of Denmark [164019]; Capital
   Region of Denmark; Augustinus Foundation; Danish Council for Independent
   Research, Medical Sciences [DFF-4183-00570]; A.P. MOller Foundation for
   the Advancement of Medical Science [15-55]; Beckett-Fonden [48282];
   Lundbeck Foundation
FX This study was supported by grants from the Mental Health Services,
   Capital Region of Denmark (PhD student 164019 and the BIO study), The
   Capital Region of Denmark, the Augustinus Foundation, The Danish Council
   for Independent Research, Medical Sciences (DFF-4183-00570), the A.P.
   MOller Foundation for the Advancement of Medical Science (15-55), and
   Beckett-Fonden (48282). Helena Lykke BOgh received a scholarship in
   psychiatry from The Lundbeck Foundation. We thank the laboratory of
   clinical pharmacology Rigshospitalet/Bispebjerg Frederiksberg Hospital
   for the 8-oxodG and 8-oxoGuo analysis
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Amare AT, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/tp.2016.261
   Andreazza AC, 2010, ARCH GEN PSYCHIAT, V67, P360, DOI 10.1001/archgenpsychiatry.2010.22
   Ashar FN, 2017, JAMA CARDIOL, V2, P1247, DOI 10.1001/jamacardio.2017.3683
   Berry JD, 2009, CIRCULATION, V119, P382, DOI 10.1161/CIRCULATIONAHA.108.800235
   Brown NC, 2014, PSYCHIAT RES, V218, P61, DOI 10.1016/j.psychres.2014.04.005
   Chen PH, 2023, AUST NZ J PSYCHIAT, V57, P104, DOI 10.1177/00048674211062532
   Clay HB, 2011, INT J DEV NEUROSCI, V29, P311, DOI 10.1016/j.ijdevneu.2010.08.007
   Coello K, 2021, FREE RADICAL BIO MED, V168, P226, DOI 10.1016/j.freeradbiomed.2021.03.022
   Coello K, 2019, AUST NZ J PSYCHIAT, V53, P651, DOI 10.1177/0004867418815987
   Coello K, 2019, INT J BIPOLAR DISORD, V7, DOI 10.1186/s40345-019-0142-3
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   Evans MD, 2010, FASEB J, V24, P1249, DOI 10.1096/fj.09-147124
   Gast KB, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0052036
   Golding J, 2013, INT J EPIDEMIOL, V42, P1145, DOI 10.1093/ije/dyt095
   Goldstein BI, 2020, BIPOLAR DISORD, V22, P440, DOI 10.1111/bdi.12921
   Goldstein BI, 2015, CIRCULATION, V132, P965, DOI 10.1161/CIR.0000000000000229
   Goldstein BI, 2015, J CLIN PSYCHIAT, V76, P163, DOI 10.4088/JCP.14m09300
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Hatch J, 2015, J PSYCHOSOM RES, V79, P222, DOI 10.1016/j.jpsychores.2015.04.005
   Henriksen T, 2021, FREE RADICAL BIO MED, V172, P350, DOI 10.1016/j.freeradbiomed.2021.06.014
   Jacoby AS, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.141
   Kessing LV, 2021, J AFFECT DISORDERS, V282, P18, DOI 10.1016/j.jad.2020.12.072
   Kessing LV, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2016-015462
   Kessing LV, 2015, J AFFECT DISORDERS, V180, P142, DOI 10.1016/j.jad.2015.03.027
   Kjær LK, 2017, DIABETES CARE, V40, P1771, DOI 10.2337/dc17-1150
   Kuperberg M, 2021, CURR TOP BEHAV NEURO, V48, P61, DOI 10.1007/7854_2020_152
   Laing ST, 2012, ECHOCARDIOGR-J CARD, V29, P1224, DOI 10.1111/j.1540-8175.2012.01774.x
   Lundberg M, 2020, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.586083
   Mahjoub S, 2012, CASP J INTERN MED, V3, P386
   Munkholm K, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.110
   Munkholm K, 2015, BIPOLAR DISORD, V17, P257, DOI 10.1111/bdi.12245
   Ormazabal V, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0762-4
   Pencina MJ, 2009, CIRCULATION, V119, P3078, DOI 10.1161/CIRCULATIONAHA.108.816694
   Poulsen HE, 2012, FREE RADICAL BIO MED, V52, P1353, DOI 10.1016/j.freeradbiomed.2012.01.009
   Rizzo LB, 2014, NEUROSCI BIOBEHAV R, V42, P157, DOI 10.1016/j.neubiorev.2014.02.004
   Sletved KSO, 2023, PSYCHOL MED, V53, P706, DOI 10.1017/S0033291721002026
   Steven S, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/7092151
   Vancampfort D, 2015, J CLIN PSYCHIAT, V76, P1490, DOI 10.4088/JCP.14r09635
   WING JK, 1990, ARCH GEN PSYCHIAT, V47, P589
   YOUNG RC, 1978, BRIT J PSYCHIAT, V133, P429, DOI 10.1192/bjp.133.5.429
NR 42
TC 7
Z9 7
U1 0
U2 1
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD AUG 10
PY 2022
VL 12
IS 1
AR 327
DI 10.1038/s41398-022-02095-6
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA 3R1AH
UT WOS:000838651100003
PM 35948543
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Fry, JL
   Al Sayah, L
   Weisbrod, RM
   Van Roy, I
   Weng, X
   Cohen, RA
   Bachschmid, MM
   Seta, F
AF Fry, Jessica L.
   Al Sayah, Leona
   Weisbrod, Robert M.
   Van Roy, Isabelle
   Weng, Xiang
   Cohen, Richard A.
   Bachschmid, Markus M.
   Seta, Francesca
TI Vascular Smooth Muscle Sirtuin-1 Protects Against Diet-Induced Aortic
   Stiffness
SO HYPERTENSION
LA English
DT Article
DE aorta; arterial stiffness; cardiovascular disease; metabolic syndrome;
   obesity; sirtuin-1; vascular smooth muscle
ID PULSE-WAVE VELOCITY; ARTERIAL STIFFNESS; CARDIOVASCULAR EVENTS; CALORIE
   RESTRICTION; BLOOD-PRESSURE; INCIDENT HYPERTENSION; SIRT1 DEACETYLASE;
   OXIDATIVE STRESS; CELL-SURVIVAL; HEART-DISEASE
AB Arterial stiffness, a major cardiovascular risk factor, develops within 2 months in mice fed a high-fat, high-sucrose (HFHS) diet, serving as a model of human metabolic syndrome, and it is associated with activation of proinflammatory and oxidant pathways in vascular smooth muscle (VSM) cells. Sirtuin-1 (SirT1) is an NAD+-dependent deacetylase regulated by the cellular metabolic status. Our goal was to study the effects of VSM SirT1 on arterial stiffness in the context of diet-induced metabolic syndrome. Overnight fasting acutely decreased arterial stiffness, measured in vivo by pulse wave velocity, in mice fed HFHS for 2 or 8 months, but not in mice lacking SirT1 in VSM (SMKO). Similarly, VSM-specific genetic SirT1 overexpression (SMTG) prevented pulse wave velocity increases induced by HFHS feeding, during 8 months. Administration of resveratrol or S17834, 2 polyphenolic compounds known to activate SirT1, prevented HFHS-induced arterial stiffness and were mimicked by global SirT1 overexpression (SirT1 bacterial artificial chromosome overexpressor), without evident metabolic improvements. In addition, HFHS-induced pulse wave velocity increases were reversed by 1-week treatment with a specific, small molecule SirT1 activator (SRT1720). These beneficial effects of pharmacological or genetic SirT1 activation, against HFHS-induced arterial stiffness, were associated with a decrease in nuclear factor kappa light chain enhancer of activated B cells (NF kappa B) activation and vascular cell adhesion molecule (VCAM-1) and p47phox protein expressions, in aorta and VSM cells. In conclusion, VSM SirT1 activation decreases arterial stiffness in the setting of obesity by stimulating anti-inflammatory and antioxidant pathways in the aorta. SirT1 activators may represent a novel therapeutic approach to prevent arterial stiffness and associated cardiovascular complications in overweight/obese individuals with metabolic syndrome.
C1 [Fry, Jessica L.; Al Sayah, Leona; Weisbrod, Robert M.; Van Roy, Isabelle; Weng, Xiang; Cohen, Richard A.; Bachschmid, Markus M.; Seta, Francesca] Boston Univ, Sch Med, Vasc Biol Sect, Med Campus, Boston, MA USA.
C3 Boston University
RP Seta, F (corresponding author), Boston Univ, Sch Med, Vasc Biol Sect, 650 Albany St,X726, Boston, MA 02118 USA.
EM setaf@bu.edu
RI Seta, Francesca/ABB-1566-2020; Stefanadis, Christodoulos/ABH-2232-2020
OI /0000-0002-1070-6408; Bachschmid, Markus Michael/0000-0002-0748-5528;
   Fry, Jessica/0000-0003-2748-0334; Seta, Francesca/0000-0001-7985-5615;
   Stefanadis, Christodoulos/0000-0001-5974-6454
FU NHLBI [HL105287]; Evans Center for Interdisciplinary Biomedical Research
   Arterial Stiffness Affinity Research Collaboratives (ARC) at Boston
   University; NIDDK [R01 DK103750]; Ruth Kirschstein Postdoctoral
   Fellowship at the Whitaker Cardiovascular Institute Multidisciplinary
   Training Program [T32 HL07224]; Marfan's Foundation Early Investigator
   grant; Boston University Evans Fellow award; Strategic Alliance; Servier
   Pharmaceutical Company
FX This work was supported by NHLBI R01 grant HL105287 and was partially
   supported by the Evans Center for Interdisciplinary Biomedical Research
   Arterial Stiffness Affinity Research Collaboratives (ARC) at Boston
   University (http://www.bumc.bu.edu/evanscenteribr/), NIDDK R01 DK103750
   grant, a Ruth Kirschstein Postdoctoral Fellowship T32 HL07224 at the
   Whitaker Cardiovascular Institute Multidisciplinary Training Program, a
   Marfan's Foundation Early Investigator grant, a Boston University Evans
   Fellow award, and a Strategic Alliance with Servier Pharmaceutical
   Company. This work was accomplished, in part, with the use of the Boston
   University Analytical Instrumentation Core.
CR AlGhatrif M, 2013, HYPERTENSION, V62, P934, DOI 10.1161/HYPERTENSIONAHA.113.01445
   Banks AS, 2008, CELL METAB, V8, P333, DOI 10.1016/j.cmet.2008.08.014
   Baur JA, 2006, NATURE, V444, P337, DOI 10.1038/nature05354
   Baur JA, 2006, NAT REV DRUG DISCOV, V5, P493, DOI 10.1038/nrd2060
   Baur JA, 2010, BBA-PROTEINS PROTEOM, V1804, P1626, DOI 10.1016/j.bbapap.2009.10.025
   Bordone L, 2005, NAT REV MOL CELL BIO, V6, P298, DOI 10.1038/nrm1616
   Cohen HY, 2004, SCIENCE, V305, P390, DOI 10.1126/science.1099196
   Ding J, 2015, ARTERIOSCL THROM VAS, V35, P1889, DOI 10.1161/ATVBAHA.115.305451
   Donato AJ, 2013, AGING CELL, V12, P772, DOI 10.1111/acel.12103
   Fry JL, 2015, J AM HEART ASSOC, V4, DOI 10.1161/JAHA.115.002384
   Gao YZ, 2014, AM J PHYSIOL-HEART C, V307, pH1252, DOI 10.1152/ajpheart.00392.2014
   Gillum MP, 2011, TRENDS MOL MED, V17, P8, DOI 10.1016/j.molmed.2010.09.005
   Guarente L, 2005, MECH AGEING DEV, V126, P923, DOI 10.1016/j.mad.2005.03.013
   Guo S, 2015, MOL CELL ENDOCRINOL, V412, P85, DOI 10.1016/j.mce.2015.05.034
   Haigis MC, 2010, ANNU REV PATHOL-MECH, V5, P253, DOI 10.1146/annurev.pathol.4.110807.092250
   Handa P, 2011, ARTERIOSCL THROM VAS, V31, P2827, DOI 10.1161/ATVBAHA.111.236554
   Hansen TW, 2006, CIRCULATION, V113, P664, DOI 10.1161/CIRCULATIONAHA.105.579342
   Harbeck B, 2000, J BIOL CHEM, V275, P30817, DOI 10.1074/jbc.M005066200
   Hayashida S, 2010, MOL CELL BIOCHEM, V339, P285, DOI 10.1007/s11010-010-0391-z
   Hsu WW, 2016, ACS CHEM BIOL, V11, P792, DOI 10.1021/acschembio.5b00886
   Huang KP, 2013, FREE RADICAL BIO MED, V65, P528, DOI 10.1016/j.freeradbiomed.2013.07.029
   Kaess BM, 2012, JAMA-J AM MED ASSOC, V308, P875, DOI 10.1001/2012.jama.10503
   Kulkarni SR, 2014, ANTIOXID REDOX SIGN, V20, P15, DOI 10.1089/ars.2012.5082
   Lyle AN, 2006, PHYSIOLOGY, V21, P269, DOI 10.1152/physiol.00004.2006
   Matsumoto S, 2003, FREE RADICAL RES, V37, P767, DOI 10.1080/1071576031000107344
   Mattace-Raso FUS, 2006, CIRCULATION, V113, P657, DOI 10.1161/CIRCULATIONAHA.105.555235
   Mattison JA, 2014, CELL METAB, V20, P183, DOI 10.1016/j.cmet.2014.04.018
   Mattison JA, 2012, NATURE, V489, P318, DOI 10.1038/nature11432
   Michener KH, 2015, AM J NEPHROL, V41, P320, DOI 10.1159/000431332
   Minor RK, 2011, SCI REP-UK, V1, DOI 10.1038/srep00070
   Mitchell GF, 2010, CIRCULATION, V121, P505, DOI 10.1161/CIRCULATIONAHA.109.886655
   Mozaffarian D, 2016, CIRCULATION, V133, pE38, DOI 10.1161/CIR.0000000000000350
   Murdoch CE, 2014, J BIOL CHEM, V289, P8633, DOI 10.1074/jbc.M113.517219
   Najjar SS, 2008, J AM COLL CARDIOL, V51, P1377, DOI 10.1016/j.jacc.2007.10.065
   Park SJ, 2012, CELL, V148, P421, DOI 10.1016/j.cell.2012.01.017
   Pase MP, 2016, HYPERTENSION, V67, P513, DOI 10.1161/HYPERTENSIONAHA.115.06610
   Pfluger PT, 2008, P NATL ACAD SCI USA, V105, P9793, DOI 10.1073/pnas.0802917105
   Qin ZX, 2014, J MOL CELL CARDIOL, V72, P56, DOI 10.1016/j.yjmcc.2014.02.019
   Qiu HY, 2010, CIRC RES, V107, P615, DOI 10.1161/CIRCRESAHA.110.221846
   Sehgel NL, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00335
   Sutton-Tyrrell K, 2005, CIRCULATION, V111, P3384, DOI 10.1161/CIRCULATIONAHA.104.483628
   Sutton-Tyrrell K, 2001, HYPERTENSION, V38, P429, DOI 10.1161/01.HYP.38.3.429
   Tong XY, 2016, J MOL CELL CARDIOL, V92, P30, DOI 10.1016/j.yjmcc.2016.01.020
   Tsao CW, 2016, NEUROLOGY, V86, P619, DOI 10.1212/WNL.0000000000002368
   Tsao CW, 2015, J AM HEART ASSOC, V4, DOI 10.1161/JAHA.115.002189
   Vlachopoulos C, 2010, EUR HEART J, V31, P1865, DOI 10.1093/eurheartj/ehq024
   Wang MY, 2010, CURR HYPERTENS REV, V6, P266, DOI 10.2174/157340210793611668
   Weisbrod RM, 2013, HYPERTENSION, V62, P1105, DOI 10.1161/HYPERTENSIONAHA.113.01744
   Yeung F, 2004, EMBO J, V23, P2369, DOI 10.1038/sj.emboj.7600244
   Zieman SJ, 2005, ARTERIOSCL THROM VAS, V25, P932, DOI 10.1161/01.ATV.0000160548.78317.29
NR 50
TC 73
Z9 83
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD SEP
PY 2016
VL 68
IS 3
BP 775
EP +
DI 10.1161/HYPERTENSIONAHA.116.07622
PG 22
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DT1ZK
UT WOS:000381280400034
PM 27432859
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Mizukawa, M
   Ohmori, K
   Obayashi, A
   Ishihara, Y
   Yoshida, J
   Noma, T
   Yukiiri, K
   Kosaka, H
   Kohno, M
AF Mizukawa, Mizuki
   Ohmori, Koji
   Obayashi, Ayumi
   Ishihara, Yasuhiro
   Yoshida, Junji
   Noma, Takahisa
   Yukiiri, Kazushi
   Kosaka, Hiroaki
   Kohno, Masakazu
TI Effects of combined olmesartan and pravastatin on glucose intolerance
   and cardiovascular remodeling in a metabolic-syndrome model
SO HYPERTENSION RESEARCH
LA English
DT Article
DE adiponectin; diabetes mellitus; dihydrofolate reductase; endothelial
   nitric oxide synthetase; oxidative stress
ID DIABETES-MELLITUS; PLASMA ADIPONECTIN; TYPE-1 RECEPTOR; ADIPOSE-TISSUE;
   RAT MODEL; ATORVASTATIN; OBESITY
AB Hypertension and dyslipidemia frequently coexist in patients with progressive insulin resistance and thus constitute metabolic syndrome. We sought to determine the merits of combining an angiotensin II receptor blocker and a 3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitor in treating this pathological condition. Five-week-old Otsuka Long-Evans Tokushima Fatty rats, a model of metabolic syndrome, were untreated or treated with olmesartan 3 mg kg(-1) per day, pravastatin 30 mg kg(-1) per day or their combination for 25 weeks. Long-Evans Tokushima Otsuka rats served as normal controls. The antihypertensive effect of olmesartan and the lipid-lowering properties of pravastatin were both augmented by the combination. The oral glucose tolerance test revealed that only the combined treatment significantly reduced the area under the time-glucose curve, which was accompanied by augmented adiponectin messenger RNA expression in epididymal adipose tissue. Although the total cardiac endothelial nitric oxide synthetase ( eNOS) content did not significantly differ among the groups, the combined treatment significantly increased the content of dihydrofolate reductase, a key eNOS coupler. Dihydroethidium staining of the aorta showed that the combination most significantly attenuated superoxide production. Moreover, Azan-Mallory staining revealed that the combination most significantly limited the perivascular fibrosis and wall thickening of intramyocardial coronary arteries. In conclusion, the combination of olmesartan and pravastatin augmented adiponectin expression in white adipose tissue and improved glucose tolerance in a rat model of metabolic syndrome, which was associated with more significant ameliorations of cardiovascular redox state and remodeling than those by treatments with either agent alone. Hypertension Research ( 2009) 32, 617-624; doi: 10.1038/hr.2009.63; published online 22 May 2009
C1 [Mizukawa, Mizuki; Ohmori, Koji; Obayashi, Ayumi; Ishihara, Yasuhiro; Yoshida, Junji; Noma, Takahisa; Yukiiri, Kazushi; Kohno, Masakazu] Kagawa Univ, Fac Med, Dept Cardiorenal Cerebrovasc Med, Miki, Kagawa 7610793, Japan.
   [Kosaka, Hiroaki] Kagawa Univ, Fac Med, Dept Cardiovasc Physiol, Miki, Kagawa 7610793, Japan.
C3 Kagawa University; Kagawa University
RP Ohmori, K (corresponding author), Kagawa Univ, Fac Med, Dept Cardiorenal Cerebrovasc Med, 1750-1 Ikenobe, Miki, Kagawa 7610793, Japan.
EM komori@med.kagawa-u.ac.jp
FU Daiichi-Sankyo Co. Ltd., Tokyo, Japan; Otsuka Pharmaceutical Co. Ltd.,
   Tokyo, Japan
FX This work was partly supported by a research grant from Daiichi-Sankyo
   Co. Ltd., Tokyo, Japan. The authors are grateful to Otsuka
   Pharmaceutical Co. Ltd., Tokyo, Japan for providing the OLETF rats and
   LETO rats at no cost.
CR Alp NJ, 2004, ARTERIOSCL THROM VAS, V24, P413, DOI 10.1161/01.ATV.0000110785.96039.f6
   Bullen JW, 2007, AM J PHYSIOL-ENDOC M, V292, pE1079, DOI 10.1152/ajpendo.00245.2006
   Chalupsky K, 2005, P NATL ACAD SCI USA, V102, P9056, DOI 10.1073/pnas.0409594102
   Chen Y, 2007, CIRC J, V71, P144, DOI 10.1253/circj.71.144
   Freeman DJ, 2001, CIRCULATION, V103, P357
   Guzik TJ, 2002, CIRCULATION, V105, P1656, DOI 10.1161/01.CIR.0000012748.58444.08
   Hirano T, 2006, J HYPERTENS, V24, P103, DOI 10.1097/01.hjh.0000198030.30095.98
   Hoffstedt J, 2004, J CLIN ENDOCR METAB, V89, P1391, DOI 10.1210/jc.2003-031458
   Ishikawa M, 2006, INTERNAL MED, V45, P51, DOI 10.2169/internalmedicine.45.1476
   KAWANO K, 1992, DIABETES, V41, P1422, DOI 10.2337/diabetes.41.11.1422
   Kurata A, 2006, KIDNEY INT, V70, P1717, DOI 10.1038/sj.ki.5001810
   Kurita S, 2008, EUR J PHARMACOL, V588, P316, DOI 10.1016/j.ejphar.2008.04.028
   Li Z, 2004, HYPERTENSION, V44, P758, DOI 10.1161/01.HYP.0000145179.44166.0f
   Mita T, 2007, ENDOCR J, V54, P441, DOI 10.1507/endocrj.K06-198
   Mizushige K, 2000, CIRCULATION, V101, P899, DOI 10.1161/01.CIR.101.8.899
   Nickenig G, 1999, CIRCULATION, V100, P2131, DOI 10.1161/01.CIR.100.21.2131
   Nishimura H, 2008, HYPERTENS RES, V31, P1611, DOI 10.1291/hypres.31.1611
   Oak JH, 2007, DIABETES, V56, P118, DOI 10.2337/db06-0288
   Ran JM, 2006, METABOLISM, V55, P478, DOI 10.1016/j.metabol.2005.10.009
   Ribot J, 2008, OBESITY, V16, P723, DOI 10.1038/oby.2008.113
   Scheen AJ, 2004, DIABETES METAB, V30, P487, DOI 10.1016/S1262-3636(07)70146-5
   Sugiyama S, 2007, ATHEROSCLEROSIS, V194, pE43, DOI 10.1016/j.atherosclerosis.2006.08.023
   Takagi T, 2008, ATHEROSCLEROSIS, V196, P114, DOI 10.1016/j.atherosclerosis.2007.02.013
   Takiguchi S, 1997, GENE, V197, P169, DOI 10.1016/S0378-1119(97)00259-X
   Verdecchia P, 2004, HYPERTENSION, V43, P963, DOI 10.1161/01.HYP.0000125726.92964.ab
   Yamamoto E, 2007, ARTERIOSCL THROM VAS, V27, P556, DOI 10.1161/01.ATV.0000254855.24394.f9
   Yu Y, 2004, J AM COLL CARDIOL, V44, P904, DOI 10.1016/j.jacc.2004.04.050
   Yu Y, 2002, CARDIOVASC RES, V56, P303, DOI 10.1016/S0008-6363(02)00513-8
   Yusuf S, 2001, JAMA-J AM MED ASSOC, V286, P1882, DOI 10.1001/jama.286.15.1882
NR 29
TC 10
Z9 14
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD JUL
PY 2009
VL 32
IS 7
BP 617
EP 624
DI 10.1038/hr.2009.63
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 466QQ
UT WOS:000267677800016
PM 19461650
OA Bronze
DA 2025-06-11
ER

PT J
AU Kaplan, Ö
   Meriç, M
   Acar, Z
   Kale, A
   Demircan, S
   Yilmaz, Ö
   Demircan, G
   Miroglu, YY
AF Kaplan, Ozgur
   Meric, Murat
   Acar, Zeydin
   Kale, Abdurrahman
   Demircan, Sabri
   Yilmaz, Ozcan
   Demircan, Gunnur
   Miroglu, Yeliz Yilmaz
TI The effect of exercise and antioxidant enzyme levels in syndrome X and
   coronary slow flow phenomenon: an observational study
SO ANADOLU KARDIYOLOJI DERGISI-THE ANATOLIAN JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Coronary slow flow; syndrome X; antioxidant enzymes
ID CARDIAC SYNDROME-X; OXIDATIVE STRESS; ARTERY-DISEASE; ENDOTHELIAL
   FUNCTION; ANGINA-PECTORIS; ATHEROSCLEROSIS; HOMOCYSTEINE; MECHANISMS
AB Objective: In this study the antioxidant enzyme [catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)] levels at rest in patients with syndrome X and coronary slow flow are measured. Then it has been investigated whether there is any enzymatic difference between the normal controls and syndrome X patients or patients with coronary slow flow and ascertain if exercise has any effects on the antioxidant enzyme levels.
   Methods: Fifty-five patients were included in this prospective observational controlled study. Patients were divided into 3 groups: Group 1-normal controls (n=20); Group 2-patients with coronary slow flow (n=20); and Group 3-patients diagnosed with syndrome X (n=15). In all patients, blood samples were collected at rest and after maximal exercise. The antioxidant enzymes (SOD, CAT, Gpx) in the erythrocytes were studied for these three groups of blood sample. Statistical analysis was performed using Student t-test, Mann-Whitney U and Chi-square tests, Kruskal-Wallis variance analysis and ANOVA.
   Results: Under basal conditions the lowest SOD and GPx levels were measured in the 2nd Group, whereas significant differences in paired comparisons were observed only between the 2nd and 3rd Groups (p=0.024 vs. p<0.01, respectively) during paired comparisons. The post-exercise SOD levels were decreased significantly in the 3rd Groups when compared with the basal concentrations (p=0.014), however no significant pre- and post-exercise differences were observed in the CAT and GPx concentrations (p>0.05).
   Conclusion: The post-exercise SOD level when compared with basal SOD levels were decreased significantly in the syndrome X group, however no differences were observed between the other groups. This can be interpreted as the reduction ischemic findings are resulting from the decrease of SOD activity.
C1 [Kaplan, Ozgur; Meric, Murat; Acar, Zeydin; Kale, Abdurrahman; Demircan, Sabri; Yilmaz, Ozcan] Ondokuz Mayis Univ, Fac Med, Dept Cardiol, Samsun, Turkey.
   [Demircan, Gunnur; Miroglu, Yeliz Yilmaz] Ondokuz Mayis Univ, Fac Med, Dept Biol, Samsun, Turkey.
C3 Ondokuz Mayis University; Ondokuz Mayis University
RP Kaplan, Ö (corresponding author), Malatya Devlet Hastanesi Beydagi Kampusu, Kardiyol Serv, Malatya, Turkey.
EM drozgurkaplan@yahoo.com
RI Mühendislik Fakültesi, Harran Üniversitesi/GXH-7079-2022; Demircan,
   Sabri/MSZ-6783-2025
CR Akyuz F, 1998, KLIN GELISIM, V11, P409
   Amirkhizi Farshad, 2010, J Res Med Sci, V15, P270
   Çamsari A, 2003, CIRC J, V67, P1022, DOI 10.1253/circj.67.1022
   Chen LC, 2001, CHEST, V120, P1525, DOI 10.1378/chest.120.5.1525
   Demircan S, 2008, CORONARY ARTERY DIS, V19, P99, DOI 10.1097/MCA.0b013e3282f27c34
   DUTHIE GG, 1990, ARCH BIOCHEM BIOPHYS, V282, P78, DOI 10.1016/0003-9861(90)90089-H
   Erbay AR, 2005, INT J CARDIOL, V102, P419, DOI 10.1016/j.ijcard.2004.05.064
   Erdamar H, 2009, CORONARY ARTERY DIS, V20, P238, DOI 10.1097/MCA.0b013e32830936bb
   Espinola-Klein C, 2007, AM J CARDIOL, V99, P808, DOI 10.1016/j.amjcard.2006.10.041
   Fadillioglu E, 2000, B CLIN PSYCHOPHARMAC, V10, P194
   Fragasso G, 2009, INT J CARDIOL, V137, P137, DOI 10.1016/j.ijcard.2008.06.070
   Gibson CM, 1996, CIRCULATION, V93, P879, DOI 10.1161/01.CIR.93.5.879
   Gur M, 2007, CORONARY ARTERY DIS, V18, P89, DOI 10.1097/MCA.0b013e32801104e8
   Kaminski K, 2008, Acute Card Care, V10, P121, DOI 10.1080/17482940701744334
   Kurtoglu N, 2001, AM J CARDIOL, V87, P777, DOI 10.1016/S0002-9149(00)01503-4
   Mangieri M, 1996, CATHET CARDIOVASC DI, V37, P375
   Misra P, 2008, ANGIOLOGY, V59, P469, DOI 10.1177/0003319707309651
   MOSSERI M, 1986, CIRCULATION, V74, P964, DOI 10.1161/01.CIR.74.5.964
   Panting JR, 2002, NEW ENGL J MED, V346, P1948, DOI 10.1056/NEJMoa012369
   Pizzi C, 2004, CIRCULATION, V109, P53, DOI 10.1161/01.CIR.0000100722.34034.E4
   POTTS SG, 1995, PSYCHOL MED, V25, P339, DOI 10.1017/S0033291700036242
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Sezgin AT, 2003, CORONARY ARTERY DIS, V14, P155, DOI 10.1097/00019501-200304000-00008
   TAMBE AA, 1972, AM HEART J, V84, P66, DOI 10.1016/0002-8703(72)90307-9
   Tang NP, 2008, CLIN CHIM ACTA, V395, P89, DOI 10.1016/j.cca.2008.05.013
   Tanriverdi H, 2007, CARDIOLOGY, V107, P313, DOI 10.1159/000099068
   Torzewski M, 2007, ARTERIOSCL THROM VAS, V27, P850, DOI 10.1161/01.ATV.0000258809.47285.07
NR 27
TC 4
Z9 4
U1 0
U2 8
PU AVES YAYINCILIK
PI FINDIKZADE
PA IBRAHIM KARA, KIZILELMA CAD 5-3, FINDIKZADE, ISTANBUL 34096, TURKEY
SN 1302-8723
EI 1308-0032
J9 ANADOLU KARDIYOL DER
JI Anadolu Kardiyol. Derg.
PD NOV
PY 2013
VL 13
IS 7
BP 641
EP 646
DI 10.5152/akd.2013.186
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 256JG
UT WOS:000327305700003
PM 23912786
DA 2025-06-11
ER

PT J
AU Henkel, J
   Coleman, CD
   Schraplau, A
   Jöhrens, K
   Weber, D
   Castro, JP
   Hugo, M
   Schulz, TJ
   Krämer, S
   Schürmann, A
   Püschel, GP
AF Henkel, Janin
   Coleman, Charles Dominic
   Schraplau, Anne
   Joehrens, Korinna
   Weber, Daniela
   Castro, Jose Pedro
   Hugo, Martin
   Schulz, Tim Julius
   Kraemer, Stephanie
   Schuermann, Annette
   Pueschel, Gerhard Paul
TI Induction of Steatohepatitis (NASH) with Insulin Resistance in Wild-type
   B6 Mice by a Western-type Diet Containing Soybean Oil and Cholesterol
SO MOLECULAR MEDICINE
LA English
DT Article
ID FATTY LIVER-DISEASE; HEPATIC STEATOSIS; KUPFFER CELLS; INFLAMMATION;
   PATHOGENESIS; OBESE; HEPATOCYTES; INHIBITION; FIBROSIS; MODELS
AB Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are hepatic manifestations of the metabolic syndrome. Many currently used animal models of NAFLD/NASH lack clinical features of either NASH or metabolic syndrome such as hepatic inflammation and fibrosis (e.g., high-fat diets) or overweight and insulin resistance (e.g., methionine-choline-deficient diets), or they are based on monogenetic defects (e.g., ob/ob mice). In the current study, a Western-type diet containing soybean oil with high n-6-PUFA and 0.75% cholesterol (SOD + Cho) induced steatosis, inflammation and fibrosis accompanied by hepatic lipid peroxidation and oxidative stress in livers of C57BL/6-mice, which in addition showed increased weight gain and insulin resistance, thus displaying a phenotype closely resembling all clinical features of NASH in patients with metabolic syndrome. In striking contrast, a soybean oil-containing Western-type diet without cholesterol (SOD) induced only mild steatosis but not hepatic inflammation, fibrosis, weight gain or insulin resistance. Another high-fat diet, mainly consisting of lard and supplemented with fructose in drinking water (LAD + Fru), resulted in more prominent weight gain, insulin resistance and hepatic steatosis than SOD + Cho, but livers were devoid of inflammation and fibrosis. Although both LAD + Fru-and SOD + Cho-fed animals had high plasma cholesterol, liver cholesterol was elevated only in SOD + Cho animals. Cholesterol induced expression of chemotactic and inflammatory cytokines in cultured Kupffer cells and rendered hepatocytes more susceptible to apoptosis. In summary, dietary cholesterol in the SOD + Cho diet may trigger hepatic inflammation and fibrosis. SOD + Cho-fed animals may be a useful disease model displaying many clinical features of patients with the metabolic syndrome and NASH.
C1 [Henkel, Janin; Coleman, Charles Dominic; Schraplau, Anne; Pueschel, Gerhard Paul] Univ Potsdam, Inst Nutr Sci, Dept Nutr Biochem, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany.
   [Joehrens, Korinna] Charite, Inst Pathol, Berlin, Germany.
   [Schulz, Tim Julius] German Inst Human Nutr, Dept Adipocyte Dev & Nutr, Nuthetal, Germany.
   [Kraemer, Stephanie] German Inst Human Nutr, Anim Facil, Nuthetal, Germany.
   [Schuermann, Annette] German Inst Human Nutr, Dept Expt Diabetol, Nuthetal, Germany.
   [Castro, Jose Pedro; Schulz, Tim Julius; Schuermann, Annette] German Ctr Diabet Res, Munich, Germany.
   [Weber, Daniela; Castro, Jose Pedro; Hugo, Martin] German Inst Human Nutr, Dept Mol Toxicol, Nuthetal, Germany.
   [Castro, Jose Pedro] Univ Porto, Dept Biomed, Fac Med, Oporto, Portugal.
   [Castro, Jose Pedro] Inst Innovat & Hlth Res, Aging & Stress Grp, Oporto, Portugal.
   [Weber, Daniela] NutriAct Competence Cluster Nutr Res Berlin Potsd, Nuthetal, Germany.
C3 University of Potsdam; Berlin Institute of Health; Free University of
   Berlin; Humboldt University of Berlin; Charite Universitatsmedizin
   Berlin; Leibniz Association; Deutsches Institut fur Ernahrungsforschung
   Potsdam-Rehbrucke (DIfE); Leibniz Association; Deutsches Institut fur
   Ernahrungsforschung Potsdam-Rehbrucke (DIfE); Leibniz Association;
   Deutsches Institut fur Ernahrungsforschung Potsdam-Rehbrucke (DIfE);
   German Center for Diabetes Research (DZD); Leibniz Association;
   Deutsches Institut fur Ernahrungsforschung Potsdam-Rehbrucke (DIfE);
   Universidade do Porto
RP Henkel, J (corresponding author), Univ Potsdam, Inst Nutr Sci, Dept Nutr Biochem, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany.
EM jhenkel@uni-potsdam.de
RI Hugo, Martín/AAW-8351-2020; Henkel, Janin/K-2063-2019; Schulz,
   Tim/F-4842-2013
OI Schurmann, Annette/0000-0002-4113-4377; Castro, Jose
   Pedro/0000-0002-2627-5331; Schulz, Tim/0000-0002-8413-3972; Hugo,
   Martin/0000-0003-3430-6457; Weber, Daniela/0000-0002-2054-6233
FU German Research Foundation [HE-7032/1-1]
FX This work was funded in part by the German Research Foundation (grant
   HE-7032/1-1).
CR Bieghs V, 2012, HEPATOLOGY, V56, P894, DOI 10.1002/hep.25660
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Brunt EM, 2010, NAT REV GASTRO HEPAT, V7, P195, DOI 10.1038/nrgastro.2010.21
   Cadenas E, 2010, THIOL REDOX TRANSI B
   Calder PC, 2009, BIOCHIMIE, V91, P791, DOI 10.1016/j.biochi.2009.01.008
   Castro JP, 2012, FREE RADICAL BIO MED, V53, P916, DOI 10.1016/j.freeradbiomed.2012.06.005
   Charlton M, 2011, AM J PHYSIOL-GASTR L, V301, pG825, DOI 10.1152/ajpgi.00145.2011
   Deol P, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0132672
   Dowman JK, 2010, QJM-INT J MED, V103, P71, DOI 10.1093/qjmed/hcp158
   Duewell P, 2010, NATURE, V464, P1357, DOI 10.1038/nature08938
   Fayyaz S, 2014, DIABETOLOGIA, V57, P373, DOI 10.1007/s00125-013-3123-6
   Fennekohl A, 2002, J HEPATOL, V36, P328, DOI 10.1016/S0168-8278(01)00277-X
   Froh M., 2003, CURR PROTOC TOXICOL, V14
   Hebbard L, 2011, NAT REV GASTRO HEPAT, V8, P34, DOI 10.1038/nrgastro.2010.191
   Henkel J, 2012, LAB INVEST, V92, P1597, DOI 10.1038/labinvest.2012.128
   Henkel J, 2011, LAB INVEST, V91, P1107, DOI 10.1038/labinvest.2011.47
   Henkel J, 2009, HEPATOLOGY, V50, P781, DOI 10.1002/hep.23064
   Ikejima K, 2005, HEPATOL RES, V33, P151, DOI 10.1016/j.hepres.2005.09.024
   Ioannou GN, 2016, TRENDS ENDOCRIN MET, V27, P84, DOI 10.1016/j.tem.2015.11.008
   Ioannou GN, 2013, J LIPID RES, V54, P1326, DOI 10.1194/jlr.M034876
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Lazic M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0107658
   Lee HJ, 2016, LIPIDS, V51, P715, DOI 10.1007/s11745-016-4159-4
   Leroux A, 2012, J HEPATOL, V57, P141, DOI 10.1016/j.jhep.2012.02.028
   Liang T, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0124173
   Liang W, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0115922
   Longato L, 2013, FIBROGENESIS TISSUE, V6, DOI 10.1186/1755-1536-6-14
   Manowsky J, 2016, AM J PHYSIOL-ENDOC M, V310, pE938, DOI 10.1152/ajpendo.00427.2015
   Matsuzawa N, 2007, HEPATOLOGY, V46, P1392, DOI 10.1002/hep.21874
   Midtbo LK, 2015, J NUTR BIOCHEM, V26, P585, DOI 10.1016/j.jnutbio.2014.12.005
   Midtbo LK, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0053094
   Nakayama H, 2007, METABOLISM, V56, P470, DOI 10.1016/j.metabol.2006.11.004
   Okumura K, 2006, HEPATOL RES, V36, P217, DOI 10.1016/j.hepres.2006.07.009
   Parker HM, 2012, J HEPATOL, V56, P944, DOI 10.1016/j.jhep.2011.08.018
   Postic C, 2004, DIABETES METAB, V30, P398, DOI 10.1016/S1262-3636(07)70133-7
   Puschel G P, 1994, Prog Liver Dis, V12, P19
   Rajamäki K, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011765
   Ramadori P, 2015, LAB ANIM-UK, V49, P47, DOI 10.1177/0023677215570078
   Reid DT, 2015, NUTR RES REV, V28, P133, DOI 10.1017/S0954422415000128
   Rinella ME, 2008, J LIPID RES, V49, P1068, DOI 10.1194/jlr.M800042-JLR200
   Rossmeisl M, 2014, BBA-MOL CELL BIOL L, V1841, P267, DOI 10.1016/j.bbalip.2013.11.010
   Sampey BP, 2011, OBESITY, V19, P1109, DOI 10.1038/oby.2011.18
   Sanches SCL, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/574832
   Savard C, 2013, HEPATOLOGY, V57, P81, DOI 10.1002/hep.25789
   Schneider CA, 2012, NAT METHODS, V9, P671, DOI 10.1038/nmeth.2089
   Spruss A, 2012, MOL MED, V18, P1346, DOI 10.2119/molmed.2012.00223
   Subramanian S, 2011, J LIPID RES, V52, P1626, DOI 10.1194/jlr.M016246
   Tilg H, 2010, HEPATOLOGY, V52, P1836, DOI 10.1002/hep.24001
   van Rooyen DM, 2011, GASTROENTEROLOGY, V141, P1393, DOI 10.1053/j.gastro.2011.06.040
   Weber D, 2014, EUR J CLIN NUTR, V68, P215, DOI 10.1038/ejcn.2013.263
   World Gastroenterological Organisation, 2012, NON FATT LIV DIS NON
   Wortham M, 2008, DIGEST DIS SCI, V53, P2761, DOI 10.1007/s10620-007-0193-7
   Yang SQ, 1997, P NATL ACAD SCI USA, V94, P2557, DOI 10.1073/pnas.94.6.2557
   Zheng SQ, 2008, EUR J PHARMACOL, V584, P118, DOI 10.1016/j.ejphar.2008.01.045
NR 54
TC 47
Z9 48
U1 0
U2 13
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1076-1551
EI 1528-3658
J9 MOL MED
JI Mol. Med.
PY 2017
VL 23
BP 70
EP 82
DI 10.2119/molmed.2016.00203
PG 13
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
   Medicine
GA EU4ER
UT WOS:000400983100004
PM 28332698
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Shi, J
   Yang, Z
   Niu, YX
   Zhang, WW
   Li, XY
   Zhang, HM
   Lin, N
   Gu, HX
   Wen, J
   Ning, G
   Qin, L
   Su, Q
AF Shi, Jie
   Yang, Zhen
   Niu, Yixin
   Zhang, Weiwei
   Li, Xiaoyong
   Zhang, Hongmei
   Lin, Ning
   Gu, Hongxia
   Wen, Jie
   Ning, Guang
   Qin, Li
   Su, Qing
TI Large mid-upper arm circumference is associated with metabolic syndrome
   in middle-aged and elderly individuals: a community-based study
SO BMC ENDOCRINE DISORDERS
LA English
DT Article
DE Metabolic syndrome; Mid-upper arm circumference; Central obesity;
   Subcutaneous fat
ID ENDOPLASMIC-RETICULUM STRESS; FATTY-ACID-METABOLISM; INSULIN-RESISTANCE;
   ADIPOSE-TISSUE; CARDIOVASCULAR-DISEASE; NECK CIRCUMFERENCE; OBESITY;
   LIPOLYSIS; LINKS; INFLAMMATION
AB Background The mid-upper arm circumference (MUAC) is a proxy for subcutaneous fat in the upper body and is a reliable screening measure for identifying individuals with abnormal regional fat distribution. The purpose of this study was to evaluate the association between MUAC and metabolic syndrome (MetS) in middle-aged and elderly individuals. Methods We measured the MUAC in a cross-sectional sample with a total of 9787 subjects aged 40 years and older. The measurement of MUAC is performed on the right arm using a non-elastic tape held midway between the acromion and the olecranon processes in duplicate, with the arm hanging loosely at the side of the body. The MetS was defined according to the Joint Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention. Results MUAC was positively correlated with waist circumference (r = 0.437, P < 0.001), BMI (r = 0.334, P < 0.001), fasting insulin (r = 0.348, P < 0.001), HOMA-IR (r = 0.134, P < 0.001), triglycerides (r = 0.138, P < 0.001), SBP (r = 0.124, P < 0.001), and DBP (r = 0.123, P < 0.001), and inversely correlated with adiponectin (r = - 0.147, P < 0.001) and HDL-cholesterol (r = - 0.176, P < 0.001) after adjusting for age and gender. Compared with the lowest quartile group, the odds ratios were substantially higher for MetS (OR 1.77; 95% CI 1.51-2.09, P for trend< 0.001) in the highest MUAC quartile group after adjustment for potential cofounder. Conclusion Large mid-upper arm circumference is significantly associated with metabolic syndrome in middle-aged and elderly individuals.
C1 [Shi, Jie; Yang, Zhen; Niu, Yixin; Zhang, Weiwei; Li, Xiaoyong; Zhang, Hongmei; Lin, Ning; Qin, Li; Su, Qing] Shanghai Jiao Tong Univ, Sch Med, Dept Endocrinol, Xinhua Hosp,Chongming Branch, 25 Nanmen Rd, Shanghai 202150, Peoples R China.
   [Shi, Jie; Yang, Zhen; Niu, Yixin; Gu, Hongxia; Qin, Li; Su, Qing] Shanghai Jiao Tong Univ, Sch Med, Dept Endocrinol, Xinhua Hosp, Shanghai 200092, Peoples R China.
   [Wen, Jie] Fudan Univ, Huashan Hosp, Dept Endocrinol & Metab, Inst Endocrinol & Diabet, Shanghai 200040, Peoples R China.
   [Ning, Guang] Shanghai Jiao Tong Univ, Sch Med, Shanghai Clin Ctr Endocrine & Metab Dis,Ruijin Ho, Shanghai Inst Endocrinol & Metab,Dept Endocrine &, Shanghai 200025, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University; Fudan
   University; Shanghai Jiao Tong University
RP Yang, Z; Qin, L; Su, Q (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Dept Endocrinol, Xinhua Hosp,Chongming Branch, 25 Nanmen Rd, Shanghai 202150, Peoples R China.
EM yangzhen@xinhuamed.com.cn; qinli@xinhuamed.com.cn;
   suqing@xinhuamed.com.cn
RI Martinez, Ramfis/I-7205-2019
FU National Natural Science Foundation of China [81670743, 81370953];
   Shanghai Health System Outstanding Young Talents Training Program
   [XYQ2013098]; Shanghai Health and Family Planning Commission [21740173]
FX This work was supported by the National Natural Science Foundation of
   China (81670743, 81370953), Shanghai Health System Outstanding Young
   Talents Training Program (XYQ2013098), Shanghai Health and Family
   Planning Commission (21740173). The funding body had no role in the
   design of the study and collection, analysis, and interpretation of data
   and in writing the manuscript.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Arner P, 2014, TRENDS ENDOCRIN MET, V25, P255, DOI 10.1016/j.tem.2014.03.002
   Basu A, 2001, AM J PHYSIOL-ENDOC M, V280, pE1000, DOI 10.1152/ajpendo.2001.280.6.E1000
   Bergman RN, 2000, TRENDS ENDOCRIN MET, V11, P351, DOI 10.1016/S1043-2760(00)00323-4
   Berk PD, 2008, HEPATOLOGY, V48, P1362, DOI 10.1002/hep.22632
   Berkley J, 2005, JAMA-J AM MED ASSOC, V294, P591, DOI 10.1001/jama.294.5.591
   Boden Guenther, 2006, Curr Diab Rep, V6, P177, DOI 10.1007/s11892-006-0031-x
   Boden G, 2011, CURR OPIN ENDOCRINOL, V18, P139, DOI 10.1097/MED.0b013e3283444b09
   Bremer AA, 2011, J CLIN ENDOCR METAB, V96, pE1782, DOI 10.1210/jc.2011-1577
   Cancello R, 2005, DIABETES, V54, P2277, DOI 10.2337/diabetes.54.8.2277
   Chaput J-P, 2017, PEDIATR OBES, V12, P439, DOI [10.1111/ijpo.12162, 10.1111/ijpo.12]
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gu DF, 2005, LANCET, V365, P1398, DOI 10.1016/S0140-6736(05)66375-1
   Guilherme A, 2008, NAT REV MOL CELL BIO, V9, P367, DOI 10.1038/nrm2391
   Guo W, 2007, AM J PHYSIOL-ENDOC M, V293, pE576, DOI 10.1152/ajpendo.00523.2006
   Guo ZK, 1999, DIABETES, V48, P1586, DOI 10.2337/diabetes.48.8.1586
   He Y, 2006, J AM COLL CARDIOL, V47, P1588, DOI 10.1016/j.jacc.2005.11.074
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   Hotamisligil GS, 2017, NATURE, V542, P177, DOI 10.1038/nature21363
   Hou YA, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2019-028904
   Jensen MD, 2008, J CLIN ENDOCR METAB, V93, pS57, DOI 10.1210/jc.2008-1585
   Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2548, DOI 10.1210/jc.2004-0395
   Kim F, 2007, CIRC RES, V100, P1589, DOI 10.1161/CIRCRESAHA.106.142851
   Koutsari C, 2011, DIABETES, V60, P2032, DOI 10.2337/db11-0154
   Liang J, 2013, DIABETES CARE, V36, pE145, DOI 10.2337/dc13-1114
   MARTIN ML, 1991, J CLIN INVEST, V88, P609, DOI 10.1172/JCI115345
   Morino K, 2006, DIABETES, V55, pS9, DOI 10.2337/db06-S002
   Nielsen S, 2004, J CLIN INVEST, V113, P1582, DOI [10.1172/JCI200421047, 10.1172/JCI21047]
   Ning G, 2012, J DIABETES, V4, P172, DOI 10.1111/j.1753-0407.2012.00182.x
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Qin L, 2014, BMC CARDIOVASC DISOR, V14, DOI 10.1186/1471-2261-14-26
   Saltiel AR, 2001, NATURE, V414, P799, DOI 10.1038/414799a
   Schaap LA, 2018, CLIN NUTR, V37, P2252, DOI 10.1016/j.clnu.2017.11.004
   Shi H, 2006, J CLIN INVEST, V116, P3015, DOI 10.1172/JCI28898
   Talma H, 2019, ARCH DIS CHILD, V104, P159, DOI 10.1136/archdischild-2017-313528
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Wijnhoven HAH, 2010, J GERONTOL A-BIOL, V65, P1107, DOI 10.1093/gerona/glq100
   Yang GR, 2010, DIABETES CARE, V33, P2465, DOI 10.2337/dc10-0798
   Yang Z, 2016, SCI REP-UK, V6, DOI 10.1038/srep37288
NR 39
TC 23
Z9 24
U1 0
U2 11
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6823
J9 BMC ENDOCR DISORD
JI BMC Endocr. Disord.
PD JUN 3
PY 2020
VL 20
IS 1
AR 78
DI 10.1186/s12902-020-00559-8
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA LY0UW
UT WOS:000540240200001
PM 32493449
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Godin, O
   Leboyer, M
   Gaman, A
   Aouizerate, B
   Berna, F
   Brunel, L
   Capdevielle, D
   Chereau, I
   Dorey, JM
   Dubertret, C
   Dubreucq, J
   Faget, C
   Gabayet, F
   Le Strat, Y
   Llorca, PM
   Misdrahi, D
   Rey, R
   Richieri, R
   Passerieux, C
   Schandrin, A
   Schuerhoff, F
   Urbach, M
   Vidalhet, P
   Girerd, N
   Fond, G
AF Godin, O.
   Leboyer, M.
   Gaman, A.
   Aouizerate, B.
   Berna, F.
   Brunel, L.
   Capdevielle, D.
   Chereau, I.
   Dorey, J. M.
   Dubertret, C.
   Dubreucq, J.
   Faget, C.
   Gabayet, F.
   Le Strat, Y.
   Llorca, P. M.
   Misdrahi, D.
   Rey, R.
   Richieri, R.
   Passerieux, C.
   Schandrin, A.
   Schuerhoff, F.
   Urbach, M.
   Vidalhet, P.
   Girerd, N.
   Fond, G.
CA Face-Sz Grp
TI Metabolic syndrome, abdominal obesity and hyperuricemia in
   schizophrenia: Results from the FACE-SZ cohort
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE Metabolic syndrome; Hyperuricemia; Abdominal obesity; Comorbidity;
   Schizophrenia
ID SERUM URIC-ACID; OF-RHEUMATOLOGY GUIDELINES; INDEPENDENT RISK-FACTOR;
   INDUCED WEIGHT-GAIN; MIDDLE-AGED MEN; CARDIOVASCULAR RISK;
   GENERAL-POPULATION; NATIONAL-HEALTH; ALL-CAUSE; METAANALYSIS
AB Objective: Abdominal obesity was suggested to be a better predictor than Metabolic Syndrome (MetS) for cardiovascular mortality, however this is has not been extensively studied in schizophrenia. Hyperuricemia (HU) was also suggested to be both an independent risk factor for greater somatic comorbidity and a global metabolic stress marker in patients with schizophrenia.
   The aim of this study was to estimate the prevalence of MetS, abdominal obesity and HU, to examine the association between metabolic parameters with HU in a cohort of French patients with schizophrenia or schizo-affective disorder (SZ), and to estimate the prevalence rates of treatment of cardio-vascular risk factors.
   Method: 240 SZ patients (age = 31.4 years, male gender 74.3%) were systematically included. Metabolic syndrome was defined according to the International Diabetes Federation and HU if serum uric acid level was above 360 mu mol/L.
   Results: MetS, abdominal obesity and HU were found respectively in 24.2%, 21.3% and 19.6% of patients. In terms of risk factors, multiple logistic regression showed that after taking into account the potential confounders, the risk for HU was higher in males (OR = 5.9, IC95 [1.7-21.4]) and in subjects with high waist circumference (OR=3.1, IC95 [1.1-8.3]) or hypertriglyceridemia (OR=4.9, IC95 [1.9-13]). No association with hypertension, low HDL cholesterol or high fasting glucose was observed. Only 10% of patients with hypertension received a specific treatment, 18% for high fasting glucose and 8% for dyslipidemia.
   Conclusions: The prevalence of MetS, abdominal obesity and hyperuricemia is elevated in French patients with schizophrenia, all of which are considerably under-diagnosed and undertreated. HU is strongly associated with abdominal obesity but not with psychiatric symptomatology. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Godin, O.; Leboyer, M.; Gaman, A.; Aouizerate, B.; Berna, F.; Brunel, L.; Capdevielle, D.; Chereau, I.; Dorey, J. M.; Dubertret, C.; Dubreucq, J.; Faget, C.; Gabayet, F.; Le Strat, Y.; Llorca, P. M.; Misdrahi, D.; Rey, R.; Richieri, R.; Passerieux, C.; Schandrin, A.; Schuerhoff, F.; Urbach, M.; Fond, G.] Fdn FondaMental, Creteil, France.
   [Godin, O.] Univ Paris 06, Sorbonne Univ, Inst Pierre Louis Epidemiol & St Publ, UMR_S 1136, F-75013 Paris, France.
   [Godin, O.] INSERM, UMR_S 1136, Inst Pierre Louis Epidmiol & St Publ, F-75013 Paris, France.
   [Leboyer, M.; Brunel, L.; Schuerhoff, F.; Fond, G.] Univ Paris Est Creteil, Pole Psychiat & Addictol Hopitaux Univ H Mondor, INSERM,DHU Pe PSY, Eq Psychiat Genet & Psychopathol 15,U955, Creteil, France.
   [Aouizerate, B.; Misdrahi, D.] Ctr Hosp Charles Perrens, F-33076 Bordeaux, France.
   [Aouizerate, B.; Misdrahi, D.] Univ Bordeaux, Bordeaux, France.
   [Berna, F.; Vidalhet, P.] Univ Strasbourg, Hop Univ Strasbourg, INSERM, Fedarat Med Translationnelle Strasbourg,U1114, Strasbourg, France.
   [Capdevielle, D.; Schandrin, A.] Univ Montpellier I, Serv Univ Psychiat Adulte, Hop Colombiere, CHRU Montpellier,Inserm 1061, Montpellier, France.
   [Chereau, I.; Llorca, P. M.] Univ Auvergne, CMP B, CHU, Fac Med,EA 7280, F-63003 Clermont Ferrand 1, France.
   [Dorey, J. M.; Rey, R.] Univ Claude Bernard Lyon 1, Ctr Hosp Vinatier, F-69678 Bron, France.
   [Dubertret, C.; Le Strat, Y.] Univ Paris Diderot, Louis Mourier Hosp, AP HP,Dept Psychiat, Sorbonne Paris Cite,Fac Med,Inserm U894, Paris, France.
   [Dubreucq, J.; Gabayet, F.] CH Alpes Isere, Ctr Referent Rehabil Psychosociale, Grenoble, France.
   [Faget, C.; Richieri, R.] Pole Univ Psychiat, AP HM, Marseille, France.
   [Passerieux, C.; Urbach, M.] Univ Versailles St Quentin Yvelines, Serv Psychiat Adulte, Ctr Hosp Versailles, UFR Sci St Simone Veil, Versailles, France.
   [Girerd, N.] Univ Lorraine, CHU Nancy, Ctr Invest Clin 9501 & U1116,INSERM, Inst Lorrain Coeur & Vaisseaux Louis Mathieu, F-54500 Vandoeuvre Les Nancy, France.
   [Aouizerate, B.] INSERM, Neuroctr Magendie, Physiopathol Plasticite Neuronale, U862, F-33000 Bordeaux, France.
   [Misdrahi, D.] CNRS, UMR 5287, INCIA, Paris, France.
C3 Sorbonne Universite; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Sorbonne Universite; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris
   (APHP); Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Hopital
   Universitaire Henri-Mondor - APHP; Institut National de la Sante et de
   la Recherche Medicale (Inserm); Universite de Bordeaux; Universite de
   Lorraine; Institut National de la Sante et de la Recherche Medicale
   (Inserm); CHU Strasbourg; Universites de Strasbourg Etablissements
   Associes; Universite de Strasbourg; Universite de Montpellier; Institut
   National de la Sante et de la Recherche Medicale (Inserm); CHU de
   Montpellier; Universite Clermont Auvergne (UCA); CHU Clermont Ferrand;
   Universite Claude Bernard Lyon 1; Universite Paris Cite; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Louis-Mourier -
   APHP; Aix-Marseille Universite; Assistance Publique-Hopitaux de
   Marseille; Centre Hospitalier de Versailles; Universite Paris Saclay;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Lorraine; CHU de Nancy; Universite de Bordeaux; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Centre
   National de la Recherche Scientifique (CNRS); CNRS - National Institute
   for Biology (INSB)
RP Fond, G (corresponding author), Hop A Chenevier, Pole Psychiat, 40 Rue Mesly, F-94010 Creteil, France.
EM guillaume.fond@gmail.com
RI GIRERD, Nicolas/D-5493-2011; Berna, Fabrice/J-2701-2019; Le Strat,
   Yann/C-9848-2013; richieri, raphaelle/E-4707-2015; Capdevielle,
   Delphine/HTO-4229-2023; Leboyer, Marion/AAW-3648-2021; Schandrin,
   Aurélie/ISV-4608-2023; JeanMichel, Dorey/KHZ-0906-2024; FOND,
   Guillaume/D-7646-2011; TESSIER, Arnaud/A-4022-2017
OI Capdevielle, Delphine/0000-0002-7146-8554; Misdrahi,
   David/0000-0003-1146-3206; dubreucq, julien/0000-0003-4079-4194;
   Aouizerate, Bruno/0000-0002-7092-7747; Berna,
   Fabrice/0000-0002-6118-0629; D'Amato, Thierry/0000-0001-8983-0315;
   LEBOYER, Marion/0000-0001-5473-3697; Girerd,
   Nicolas/0000-0002-3278-2057; FOND, Guillaume/0000-0003-3249-2030;
   DANION, Jean-Marie/0000-0002-1980-1006; RICHIERI,
   Raphaelle/0000-0002-3901-7016; REY, Romain/0000-0002-4603-3575; TESSIER,
   Arnaud/0000-0001-5758-5693
FU AP-HP (Assistance Publique des Hopitaux de Paris), Fondation Fondamental
   (RTRS Sante Mentale); Investissements d'Avenir program
   [ANR-11-IDEX-0004-02, ANR-10-COHO-10-01]; INSERM (Institut National de
   la Sante et de la Recherche Medicale)
FX This work was funded by AP-HP (Assistance Publique des Hopitaux de
   Paris), Fondation Fondamental (RTRS Sante Mentale), by the
   Investissements d'Avenir program managed by the ANR under reference
   ANR-11-IDEX-0004-02 and ANR-10-COHO-10-01, and by INSERM (Institut
   National de la Sante et de la Recherche Medicale). We express all our
   thanks to the nurses, with special thanks to Emmanuelle Abadie, and to
   the patients who were included in the present study.
CR Abel KM, 2010, INT REV PSYCHIATR, V22, P417, DOI 10.3109/09540261.2010.515205
   ADDINGTON D, 1993, J NERV MENT DIS, V181, P561, DOI 10.1097/00005053-199309000-00006
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Allison DB, 1999, AM J PSYCHIAT, V156, P1686
   Aribas A, 2014, BLOOD PRESSURE, V23, P370, DOI 10.3109/08037051.2014.933032
   Balkau B, 2003, DIABETES METAB, V29, P526, DOI 10.1016/S1262-3636(07)70067-8
   Bobes J, 2010, SCHIZOPHR RES, V119, P101, DOI 10.1016/j.schres.2010.02.1030
   Chen JH, 2009, ARTHRIT RHEUM-ARTHR, V61, P225, DOI 10.1002/art.24164
   Chiu CC, 2012, J CLIN PSYCHOPHARM, V32, P585, DOI 10.1097/JCP.0b013e3182664e64
   De Hert M, 2010, INT J METH PSYCH RES, V19, P195, DOI 10.1002/mpr.322
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Girerd N, 2009, EUR HEART J, V30, P1270, DOI 10.1093/eurheartj/ehp091
   Godin O, 2014, J CLIN PSYCHIAT, V75, P1078, DOI 10.4088/JCP.14m09038
   Han GM, 2014, J HUM HYPERTENS, V28, P579, DOI 10.1038/jhh.2014.31
   Huang Y, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039457
   Ishizaka Y, 2014, NEPHRON CLIN PRACT, V128, P49, DOI 10.1159/000362456
   Khanna D, 2012, ARTHRIT CARE RES, V64, P1431, DOI 10.1002/acr.21772
   Khanna D, 2012, ARTHRIT CARE RES, V64, P1447, DOI 10.1002/acr.21773
   Kim SY, 2010, ARTHRIT CARE RES, V62, P170, DOI 10.1002/acr.20065
   Kim SY, 2009, ARTHRIT RHEUM-ARTHR, V61, P885, DOI 10.1002/art.24612
   Leucht S, 2009, MOL PSYCHIATR, V14, P429, DOI 10.1038/sj.mp.4002136
   Li L, 2014, BMC NEPHROL, V15, DOI 10.1186/1471-2369-15-122
   Lin WY, 2008, ANN RHEUM DIS, V67, P432, DOI 10.1136/ard.2007.073601
   Liu WC, 2012, CLIN J AM SOC NEPHRO, V7, P541, DOI 10.2215/CJN.09420911
   Ma XJ, 2014, INT J PSYCHIAT CLIN, V18, P229, DOI 10.3109/13651501.2014.957705
   Martínez-St John DRJ, 2015, BRIT J GEN PRACT, V65, DOI 10.3399/bjgp15X685669
   Matsuura F, 1998, METABOLISM, V47, P929, DOI 10.1016/S0026-0495(98)90346-8
   McClave AK, 2010, AM J PUBLIC HEALTH, V100, P2464, DOI 10.2105/AJPH.2009.188136
   McGrath J, 2004, BMC MED, V2, DOI 10.1186/1741-7015-2-13
   Mitchell AJ, 2012, PSYCHOL MED, V42, P125, DOI 10.1017/S003329171100105X
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P295, DOI 10.1093/schbul/sbs082
   Newcomer JW, 2007, J CLIN PSYCHIAT, V68, P8
   Niskanen LK, 2004, ARCH INTERN MED, V164, P1546, DOI 10.1001/archinte.164.14.1546
   Pannier B, 2006, DIABETES METAB, V32, P467, DOI 10.1016/S1262-3636(07)70305-1
   Park SH, 2011, CIRC J, V75, P692, DOI 10.1253/circj.CJ-10-0631
   Pingmuangkaew P, 2015, INDIAN J CLIN BIOCHE, V30, P286, DOI 10.1007/s12291-014-0462-0
   Reininghaus U., 2014, SCHIZOPHR B
   Schürhoff F, 2015, EUR PSYCHIAT, V30, P728, DOI 10.1016/j.eurpsy.2015.05.004
   Shiraishi H, 2009, J EPIDEMIOL, V19, P12, DOI 10.2188/jea.JE20080016
   Vancampfort D, 2013, WORLD PSYCHIATRY, V12, P240, DOI 10.1002/wps.20069
   Viazzi F, 2011, REUMATISMO, V63, P253, DOI 10.4081/reumatismo.2011.253
   WHO, 2014, WHO MORT DAT DESCR S
   Xu YL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0078206
   YAMASHITA S, 1986, INT J OBESITY, V10, P255
   Yao JK, 2013, FRONT CELL NEUROSCI, V7, DOI 10.3389/fncel.2013.00090
NR 46
TC 55
Z9 58
U1 0
U2 26
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD OCT
PY 2015
VL 168
IS 1-2
BP 388
EP 394
DI 10.1016/j.schres.2015.07.047
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CS1LK
UT WOS:000361826400056
PM 26255568
DA 2025-06-11
ER

PT J
AU Bahari, H
   Zeraattalab-Motlagh, S
   Hezaveh, ZS
   Namkhah, Z
   Golafrouz, H
   Taheri, S
   Sahebkar, A
AF Bahari, Hossein
   Zeraattalab-Motlagh, Sheida
   Hezaveh, Zohreh Sajadi
   Namkhah, Zahra
   Golafrouz, Haniyeh
   Taheri, Shaghayegh
   Sahebkar, Amirhossein
TI The Effects of Sumac Consumption on Inflammatory and Oxidative Stress
   Factors: A Systematic Review of Randomized Clinical Trials
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Sumac; spice; Rhus coriaria; antioxidant; inflammation; trial
ID RHUS-CORIARIA-L.; GALLIC ACID; ANTIOXIDANT; EXTRACT; POWDER; LIFE
AB Background: Rhus coriaria L., commonly known as Sumac, is a plant from the Anacardiaceae family that is known for its high phytochemical content. These phytochemicals have the potential to effectively manage inflammation and oxidative stress. To explore the existing evidence on the impact of Sumac consumption on inflammation and oxidative stress, we conducted a systematic review of randomized controlled trials. Methods: We conducted a comprehensive search of Medline/PubMed, Scopus, and Web of Science from inception to August 2023 to identify relevant studies examining the effects of Sumac on biomarkers of inflammation and oxidative stress. The selected studies were assessed for risk of bias using the Cochrane tool. Results: A total of seven trials were included in this review. Among these trials, three focused on diabetes patients, while the remaining four involved individuals with fatty liver, overweight individuals with depression, and those with polycystic ovary or metabolic syndrome. Five studies reported the effects of Sumac on oxidative stress, with four of them demonstrating a significant reduction in malondialdehyde (MDA) levels and an increase in total antioxidant capacity (TAC) and paraoxonase 1 (PON1). Regarding inflammation, one study reported no significant difference in tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) levels between the intervention and control groups. The results for high-sensitivity C-reactive protein levels, reported in five trials, were inconsistent. Conclusion: Sumac consumption over time may positively affect oxidative stress, although short-term use shows minimal impact. While one study found no significant effect on IL-6 and TNF-alpha, hs-CRP levels could decrease or remain unchanged. Further meta-analyses are needed to fully understand Sumac's potential benefits in managing metabolic diseases.
C1 [Bahari, Hossein] Mashhad Univ Med Sci, Clin Res Inst, Transplant Res Ctr, Mashhad, Iran.
   [Bahari, Hossein; Namkhah, Zahra] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Iran.
   [Zeraattalab-Motlagh, Sheida] Univ Houston, Dept Hlth & Human Performance, Houston, TX USA.
   [Zeraattalab-Motlagh, Sheida] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Hezaveh, Zohreh Sajadi] Univ Sydney, Fac Med & Hlth, Dept Hlth Sci, Sydney, NSW, Australia.
   [Namkhah, Zahra] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Iran.
   [Golafrouz, Haniyeh] Islamic Azad Univ, Dept Med Sci & Technol, Sci & Res Branch, Tehran, Iran.
   [Taheri, Shaghayegh] Birjand Univ Med Sci, Sch Med, Dept Clin Biochem, Birjand, Iran.
   [Sahebkar, Amirhossein] Saveetha Univ, Saveetha Inst Med & Tech Sci, Saveetha Med Coll & Hosp, Ctr Global Hlth Res, Chennai, India.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Appl Biomed Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; University of Houston System; University of Houston; Tehran
   University of Medical Sciences; University of Sydney; Mashhad University
   of Medical Sciences; Islamic Azad University; Birjand University of
   Medical Sciences; Saveetha Institute of Medical & Technical Science;
   Saveetha Medical College & Hospital; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Appl Biomed Res Ctr, Mashhad, Iran.
EM amir_saheb2000@yahoo.com
RI Sahebkar, Amirhossein/B-5124-2018; bahari, hossein/AEP-7036-2022;
   Sajadi'Hezaveh, Zohreh/LEM-1778-2024
OI Bahari, Hossein/0000-0002-3787-2713
FU Transplant Research Center, Mashhad University of Medical Sciences
FX We would like to thank the Transplant Research Center, Mashhad
   University of Medical Sciences, for supporting this manuscript.
CR Abbasalipour H, 2022, J BIOCHEM MOL TOXIC, V36, DOI 10.1002/jbt.23035
   Afandak F, 2023, PHYTOTHER RES, V37, P2315, DOI 10.1002/ptr.7744
   Ahangarpour A, 2017, RES PHARM SCI, V12, P416, DOI 10.4103/1735-5362.213987
   Ahmadi A, 2022, PHARMACOL RES, V184, DOI 10.1016/j.phrs.2022.106414
   Asgary S, 2013, PEDIATR CARDIOL, V34, P1729, DOI 10.1007/s00246-013-0693-5
   Azzi A, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11081431
   Bahari H, 2023, INFLAMMOPHARMACOLOGY, V31, P2283, DOI 10.1007/s10787-023-01294-x
   Batiha GES, 2022, MOLECULES, V27, DOI 10.3390/molecules27165179
   BEGG CB, 1994, BIOMETRICS, V50, P1088, DOI 10.2307/2533446
   Bhatt P, 2007, CRIT REV ENV SCI TEC, V37, P165, DOI 10.1080/10643380600776130
   Bielecka-Dabrowa A, 2023, ARCH MED SCI, V19, P841, DOI 10.5114/aoms/167799
   Biswas SK, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/5698931
   Bujtor M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020356
   Chakraborty A, 2009, MUTAT RES-FUND MOL M, V661, P10, DOI 10.1016/j.mrfmmm.2008.10.009
   Dandekar A, 2015, METHODS MOL BIOL, V1292, P205, DOI 10.1007/978-1-4939-2522-3_15
   Dogan A, 2016, PHARM BIOL, V54, P2092, DOI 10.3109/13880209.2016.1145702
   Egger M, 1997, BMJ-BRIT MED J, V315, P629, DOI 10.1136/bmj.315.7109.629
   El Hasasna H, 2016, SCI REP-UK, V6, DOI 10.1038/srep21144
   Farag Radwan S., 2020, Biotechnology Reports, V28, pe00536, DOI 10.1016/j.btre.2020.e00536
   Furman D, 2019, NAT MED, V25, P1822, DOI 10.1038/s41591-019-0675-0
   Gabr SA, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/5861537
   Ghafouri A, 2021, PHYTOMEDICINE, V90, DOI 10.1016/j.phymed.2021.153661
   Ghorbanian B., 2017, CMJA, V7, P1805
   Giancarlo S, 2006, NAT PROD RES, V20, P882, DOI 10.1080/14786410500520186
   Hajhashemy Z, 2023, PHYTOTHER RES, V37, P1319, DOI 10.1002/ptr.7688
   Hariri N, 2020, PHYTOTHER RES, V34, P3041, DOI 10.1002/ptr.6737
   Heidari H, 2023, PHYTOTHER RES, V37, P1462, DOI 10.1002/ptr.7737
   Higgins J, Cochrane Handbook for Systematic Reviews of Interventions Internet
   Hosseini SA, 2021, BIOFACTORS, V47, P250, DOI 10.1002/biof.1713
   Hussain Tarique, 2016, Oxid Med Cell Longev, V2016, P7432797
   Iranshahi M, 2009, DARU, V17, P99
   Jaganjac M, 2022, FREE RADICAL BIO MED, V181, P154, DOI 10.1016/j.freeradbiomed.2022.02.004
   Jung CH, 2006, BIOL PHARM BULL, V29, P1603, DOI 10.1248/bpb.29.1603
   Kade IJ, 2013, NEUROCHEM RES, V38, P761, DOI 10.1007/s11064-013-0975-6
   Kahkhaie KR, 2019, INFLAMMOPHARMACOLOGY, V27, P885, DOI 10.1007/s10787-019-00607-3
   Karam BS, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-017-0604-9
   Kazemi S, 2020, COMPLEMENT THER CLIN, V41, DOI 10.1016/j.ctcp.2020.101259
   Khandia R, 2020, ADV PROTEIN CHEM STR, V119, P199, DOI [10.1016/bs.apcsb.2019.09.004, 10.1016/j.rpor.2020.04.004]
   Kundi M., 2007, BMC Pharmacol, V7, P1
   Liguori I, 2018, CLIN INTERV AGING, V13, P757, DOI 10.2147/CIA.S158513
   Mansouri MT, 2013, FOOD CHEM, V138, P1028, DOI 10.1016/j.foodchem.2012.11.022
   Mohammadi S, 2010, DARU, V18, P270
   Momeni A, 2019, MOL GENET GENOM MED, V7, DOI 10.1002/mgg3.664
   Ndrepepa G, 2019, CLIN CHIM ACTA, V493, P36, DOI 10.1016/j.cca.2019.02.022
   Page MJ, 2021, BMJ-BRIT MED J, V372, DOI [10.1136/bmj.n71, 10.1136/bmj.n160]
   Pajares M, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9071687
   Panahi Y, 2012, BRIT J NUTR, V108, P1272, DOI 10.1017/S0007114511006544
   Panigrahy D, 2021, PHARMACOL THERAPEUT, V227, DOI 10.1016/j.pharmthera.2021.107879
   Pourahmad J, 2010, FOOD CHEM TOXICOL, V48, P854, DOI 10.1016/j.fct.2009.12.021
   Rahideh ST, 2014, J RES MED SCI, V19, P933
   Reuter S, 2010, FREE RADICAL BIO MED, V49, P1603, DOI 10.1016/j.freeradbiomed.2010.09.006
   Roe K, 2021, SCAND J IMMUNOL, V93, DOI 10.1111/sji.12970
   Schauren BC, 2014, J DEV ORIG HLTH DIS, V5, P299, DOI 10.1017/S2040174414000269
   Shabbir A, 2012, J ANIM PLANT SCI, V22, P505
   Shidfar F, 2014, IRAN J PHARM RES, V13, P1249
   Sies H, 2015, REDOX BIOL, V4, P180, DOI 10.1016/j.redox.2015.01.002
   Singh V, 2020, INFLAMMATION, V43, P1589, DOI 10.1007/s10753-020-01242-9
   Skopec MM, 2010, J CHEM ECOL, V36, P236, DOI 10.1007/s10886-010-9747-9
   Soehnlein O, 2021, NAT REV DRUG DISCOV, V20, P589, DOI 10.1038/s41573-021-00198-1
   Swiatkiewicz I, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24076382
   Tan Bee Ling, 2018, Oxid Med Cell Longev, V2018, P9719584, DOI 10.1155/2018/9719584
   Yaribeygi H, 2018, CNS NEUROL DISORD-DR, V17, P207, DOI 10.2174/1871527317666180425122557
   Yaribeygi H, 2018, BIOMED PHARMACOTHER, V98, P333, DOI 10.1016/j.biopha.2017.12.077
   Zargham Hanieh, 2008, Mcgill J Med, V11, P119
NR 64
TC 0
Z9 0
U1 2
U2 3
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2024
VL 30
IS 27
BP 2142
EP 2151
DI 10.2174/0113816128305609240529114411
EA JUN 2024
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA D5J8P
UT WOS:001251794300001
PM 38920072
DA 2025-06-11
ER

PT J
AU Morrato, EH
AF Morrato, Elaine H.
TI An update on lipid profile screening in second-generation antipsychotic
   users in the USA
SO CLINICAL LIPIDOLOGY
LA English
DT Review
DE antipsychotics; dyslipidemia; lipids; risk management; screening
ID CATIE SCHIZOPHRENIA TRIAL; INDUCED WEIGHT-GAIN; METABOLIC RISK;
   MENTAL-ILLNESS; DOUBLE-BLIND; 1ST-EPISODE SCHIZOPHRENIA; CARDIOMETABOLIC
   RISK; CHILDREN; CARE; DYSLIPIDEMIA
AB Second-generation antipsychotics (SGAs) are commonly prescribed for the treatment of schizophrenia, bipolar disorder, major depression and other behavioral and neuropsychiatric conditions. Treatment with SGA medications can induce adverse metabolic side effects, including clinically significant weight gain, hyperglycemia/diabetes mellitus and dyslipidemia. Product labeling and medical guidelines recommend that patients be routinely monitored for weight gain and serum glucose and lipid abnormalities. This review provides an update on lipid profile screening for patients taking SGA medications. The review focuses primarily on evidence from the USA, including data on risk awareness, physician intent to screen patients and population-based estimates of testing rates. Patient, provider and system barriers to lipid screening are also discussed. Quality improvement examples are provided to illustrate the progress being made in improving metabolic screening of SGA users.
C1 Univ Colorado, Aurora, CO USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus
RP Morrato, EH (corresponding author), Univ Colorado, Anschutz Med Campus,POB 6508,Mailstop F443, Aurora, CO USA.
EM elaine.morrato@ucdenver.edu
FU Agency for Healthcare Research and Quality [K12HS019464]; Janssen
   Scientific Affairs, LLC; MedScape
FX This project was supported by grant number K12HS019464 from the Agency
   for Healthcare Research and Quality. The content is solely the
   responsibility of the author and does not necessarily represent the
   official views of the Agency for Healthcare Research and Quality. The
   author has received research funding from Janssen Scientific Affairs,
   LLC and MedScape. The author has no other relevant affiliations or
   financial involvement with any organization or entity with a financial
   interest in or financial conflict with the subject matter or materials
   discussed in the manuscript apart from those disclosed.
CR Alexander GC, 2011, PHARMACOEPIDEM DR S, V20, P177, DOI 10.1002/pds.2082
   Amer Diabet Assoc, 2004, DIABETES CARE, V27, P596, DOI 10.2337/diacare.27.2.596
   [Anonymous], 2012, PRESCR INF
   [Anonymous], 2012, PRESCR INF
   [Anonymous], 2009, PRESCR INF
   [Anonymous], 2012, PRESCR INF
   [Anonymous], 2012, PRESCR INF
   ARANGO C, 2009, CHILD ADOLESC PSYCHI, V18, P418, DOI DOI 10.1007/S00787-009-0749-5
   Baptista T, 2006, CAN J PSYCHIAT, V51, P192, DOI 10.1177/070674370605100310
   Barnett M, 2010, ANN CLIN PSYCHIATRY, V22, P9
   Batscha C, 2010, J PSYCHOSOC NURS MEN, V48, P44, DOI 10.3928/02793695-20100730-03
   Birkenaes AB, 2008, J CLIN PSYCHOPHARM, V28, P132, DOI 10.1097/JCP.0b013e318166c4f7
   Buckley PF, 2005, SCHIZOPHR RES, V79, P281, DOI 10.1016/j.schres.2005.04.010
   California Mental Health Care Management Program (CalMEND), 2005, CALMEND IMPR CAR TRA
   Campbell EC, 2011, PROG NEURO-PSYCHOPH, V35, P246, DOI 10.1016/j.pnpbp.2010.11.018
   Cassels C., 2009, MEDSCAPE MED NEWS
   Colton Craig W, 2006, Prev Chronic Dis, V3, pA42
   Constantine R, 2008, PSYCHIAT SERV, V59, P1162, DOI 10.1176/appi.ps.59.10.1162
   Correll CU, 2006, J AM ACAD CHILD PSY, V45, P771, DOI 10.1097/01.chi.0000220851.94392.30
   Correll Christoph U, 2010, Psychiatr Serv, V61, P892, DOI 10.1176/ps.2010.61.9.892
   Correll CU, 2009, JAMA-J AM MED ASSOC, V302, P1765, DOI 10.1001/jama.2009.1549
   De Hert M, 2011, BRIT J PSYCHIAT, V199, P99, DOI 10.1192/bjp.bp.110.084665
   De Hert M, 2011, EUR PSYCHIAT, V26, P144, DOI 10.1016/j.eurpsy.2010.09.011
   Hert M, 2012, NAT REV ENDOCRINOL, V8, P114, DOI 10.1038/nrendo.2011.156
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P138
   De Hert M, 2006, J CLIN PSYCHIAT, V67, P1889, DOI 10.4088/JCP.v67n1208
   Dragatsi Dianna, 2009, Psychiatr Serv, V60, P1298, DOI 10.1176/ps.2009.60.10.1298
   Druss BG, 2007, J CLIN PSYCHIAT, V68, P40, DOI 10.4088/JCP.0407e09
   Druss BG, 2011, MED CARE, V49, P599, DOI 10.1097/MLR.0b013e31820bf86e
   Dunbar L, 2010, AUSTRALAS PSYCHIATRY, V18, P322, DOI 10.3109/10398561003692571
   Falissard B, 2011, INT CLIN PSYCHOPHARM, V26, P291, DOI 10.1097/YIC.0b013e32834a5bf6
   Fiedorowicz JG, 2012, CURR PSYCHIATRY REV, V8, P25, DOI 10.2174/157340012798994867
   Frayne SM, 2005, ARCH INTERN MED, V165, P2631, DOI 10.1001/archinte.165.22.2631
   Goff DC, 2005, SCHIZOPHR RES, V80, P45, DOI 10.1016/j.schres.2005.08.010
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Hammerman A, 2008, ANN PHARMACOTHER, V42, P1316, DOI 10.1345/aph.1L015
   Haupt DW, 2009, AM J PSYCHIAT, V166, P345, DOI 10.1176/appi.ajp.2008.08030383
   Ho J, 2011, J CAN ACAD CHILD ADO, V20, P234
   Holt RIG, 2010, J PSYCHOPHARMACOL, V24, P867, DOI 10.1177/0269881109102788
   Hsu C, 2008, J AM PHARM ASSOC, V48, P393, DOI 10.1331/JAPhA.2008.07007
   Jerrell JM, 2012, PSYCHIAT SERV, V63, P202, DOI 10.1176/appi.ps.20120p202
   Ketter TA, 2006, CURR MED RES OPIN, V22, P2345, DOI 10.1185/030079906X148616
   Khan RA, 2009, J PSYCHIATR PRACT, V15, P320, DOI 10.1097/01.pra.0000358319.81307.a5
   Khatana SAM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019298
   Kilbourne AM, 2007, J AFFECT DISORDERS, V102, P145, DOI 10.1016/j.jad.2007.01.006
   Kilbourne AM, 2011, GEN HOSP PSYCHIAT, V33, P634, DOI 10.1016/j.genhosppsych.2011.07.003
   Kuehn BM, 2010, JAMA-J AM MED ASSOC, V303, P1901, DOI 10.1001/jama.2010.596
   Leslie DL, 2012, AM J MANAG CARE, V18, pE109
   Leucht S, 2009, LANCET, V373, P31, DOI 10.1016/S0140-6736(08)61764-X
   Li CH, 2011, PSYCHIAT SERV, V62, P1477, DOI 10.1176/appi.ps.000882011
   Lindsley C, 2010, ACS CHEM NEUROSCI, V1, P1, DOI 10.1021/cn9000439
   McEvoy JP, 2005, SCHIZOPHR RES, V80, P19, DOI 10.1016/j.schres.2005.07.014
   McIntyre RS, 2008, ARCH PEDIAT ADOL MED, V162, P929, DOI 10.1001/archpedi.162.10.929
   McIntyre RS, 2001, CAN J PSYCHIAT, V46, P273, DOI 10.1177/070674370104600308
   Mental Health America, 2008, COMM HLTH MENT HLTH
   Meyer JM, 2004, SCHIZOPHR RES, V70, P1, DOI 10.1016/j.schres.2004.01.014
   Meyer JM, 2008, SCHIZOPHR RES, V101, P273, DOI 10.1016/j.schres.2007.12.487
   Mitchell AJ, 2012, PSYCHOL MED, V42, P125, DOI 10.1017/S003329171100105X
   Moeller KE, 2011, SCHIZOPHR RES, V126, P117, DOI 10.1016/j.schres.2010.11.015
   Morrato EH, 2008, J CLIN PSYCHIAT, V69, P316, DOI 10.4088/JCP.v69n0219
   Morrato EH, 2011, PHARMACOEPIDEM DR S, V20, P66, DOI 10.1002/pds.2062
   Morrato EH, 2010, ARCH PEDIAT ADOL MED, V164, P344, DOI 10.1001/archpediatrics.2010.48
   Morrato EH, 2010, ARCH GEN PSYCHIAT, V67, P17, DOI 10.1001/archgenpsychiatry.2009.179
   Morrato EH, 2009, DIABETES CARE, V32, P1037, DOI 10.2337/dc08-1720
   Morrato EH, 2009, J CLIN PSYCHOPHARM, V29, P26, DOI 10.1097/JCP.0b013e31819294cb
   Motsinger Charles, 2006, Prim Care Companion J Clin Psychiatry, V8, P220
   Nasrallah HA, 2006, SCHIZOPHR RES, V86, P15, DOI 10.1016/j.schres.2006.06.026
   National Center for Health Statistics (US), 2011, SPEC FEAT DEATH DYIN, P2011
   Newall H, 2012, INT CLIN PSYCHOPHARM, V27, P69, DOI 10.1097/YIC.0b013e32834d0a5b
   Newcomer JW, 2007, JAMA-J AM MED ASSOC, V298, P1794, DOI 10.1001/jama.298.15.1794
   Newcomer John W, 2004, J Clin Psychopharmacol, V24, pS1, DOI 10.1097/01.jcp.0000142281.85207.d5
   Newcomer JW, 2002, ARCH GEN PSYCHIAT, V59, P337, DOI 10.1001/archpsyc.59.4.337
   Newcomer JW, 2005, CNS DRUGS, V19, P1
   Nicol GE, 2011, PSYCHIAT SERV, V62, P12, DOI 10.1176/ps.62.1.pss6201_0012
   Noosba N., 2010, MIAMI PROJECT MIRECC
   Ojala K, 2008, J PSYCHOPHARMACOL, V22, P33, DOI 10.1177/0269881107077815
   Pathak P, 2010, PSYCHIAT SERV, V61, P123, DOI 10.1176/ps.2010.61.2.123
   Rosack J., 2003, Psychiatric News, V38, P1
   Schneiderhan ME, 2009, PHARMACOTHERAPY, V29, P975, DOI 10.1592/phco.29.8.975
   Schuffman D, 2009, PSYCHIAT SERV, V60, P585, DOI 10.1176/appi.ps.60.5.585
   Sernyak MJ, 2007, J CLIN PSYCHIAT, V68, P14
   Shi LZ, 2009, BMC PSYCHIATRY, V9, DOI 10.1186/1471-244X-9-80
   Suppes T, 2007, PSYCHOPHARMACOL BULL, V40, P22
   Torres Deborra M, 2007, J Healthc Qual, V29, P48
   US FDA, 2012, STAT DURGS DRUG SAF
   US FDA, 2012, PED EXCL LAB CHANG 2
   US FDA, 2004, FDA SAFETY NEWS 0628
   Vanderlip ER, 2012, PSYCHIAT SERV, V63, P693, DOI 10.1176/appi.ps.201100475
   Verdoux H, 2010, ACTA PSYCHIAT SCAND, V121, P4, DOI 10.1111/j.1600-0447.2009.01425.x
   Vitiello B, 2009, EUR NEUROPSYCHOPHARM, V19, P629, DOI 10.1016/j.euroneuro.2009.04.008
   Walter G, 2008, AUSTRALAS PSYCHIATRY, V16, P253, DOI 10.1080/10398560801958549
   Walton SN, 2008, PHARMACOTHERAPY, V28, P1443, DOI 10.1592/phco.28.12.1443
   Weissman EM, 2006, J CLIN PSYCHIAT, V67, P1323, DOI 10.4088/JCP.v67n0901
   Weissman EM., 2011, CLIN SCHIZOPHR RELAT, V5, P201
   Wu RR, 2008, AM J PSYCHIAT, V165, P352, DOI 10.1176/appi.ajp.2007.07010079
   Wu RR, 2008, JAMA-J AM MED ASSOC, V299, P185, DOI 10.1001/jama.2007.56-b
   Wu RR, 2012, AM J PSYCHIAT, V169, P813, DOI 10.1176/appi.ajp.2012.11091432
   Zuvekas SH, 2005, HEALTH AFFAIR, V24, P195, DOI 10.1377/hlthaff.24.1.195
NR 98
TC 2
Z9 2
U1 0
U2 12
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1758-4299
EI 1758-4302
J9 CLIN LIPIDOL
JI Clin. Lipidol.
PD OCT
PY 2012
VL 7
IS 5
BP 509
EP 523
DI 10.2217/CLP.12.51
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 028IS
UT WOS:000310416600009
DA 2025-06-11
ER

PT J
AU Tunc-Ata, M
   Altintas, F
   Senol, H
   Nizamoglu, E
   Kucukatay, V
AF Tunc-Ata, Melek
   Altintas, Fatih
   Senol, Hande
   Nizamoglu, Erol
   Kucukatay, Vural
TI Ileal interposition improves metabolic syndrome parameters in a rat
   model of metabolic syndrome induced by monosodium glutamate
SO LIFE SCIENCES
LA English
DT Article
DE Metabolic syndrome; Ileal interposition; Glucagon like peptide-1;
   Glucagon like peptide-1 receptor; Monosodium glutamate
ID Y GASTRIC BYPASS; INSULIN-RESISTANCE; GLUCOSE-TOLERANCE; OXIDATIVE
   STRESS; OBESITY; GROWTH; TRANSPOSITION; SURGERY; ENERGY; MICE
AB Aims: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities. Anatomically restructuring of the gastrointestinal system has recently been an important subject of research in the treatment of MetS and closely related diseases. The aim of this study is to ensure the remission of parameters that define MetS by ileal interposition (IT) and to examine the effect of IT on plasma total GLP-1 and pancreatic GLP-1R expression.
   Main methods: To induce MetS, newborn male Wistar albino rats were given MSG (4 g/mg) on days 0, 2, 4, 6, 8, and 10. The control group was injected with saline. In the 5th month, IT or sham surgery was performed on the MetS rats. The lipid levels, abdominal obesity, insulin level, OGTT, Lee index, HOMA-IR, plasma GLP-1 and pancreas GLP-1R expression were evaluated 2 months after surgery.
   Key findings: The results showed that IT significantly improved hyperinsulinemia (p = 0.013) and lipid profile (TG p = 0.0001; TCHOL p = 0.018; HDL p = 0.001). Furthermore, it normalized the Lee index (p = 0.006) and insulin resistance. The IT did not affect the secretion of the GLP-1, but the expression levels of pancreas GLP-1R were increased (p = 0.006).
   Significance: IT surgery corrected the MetS parameters in this rat model. The healing effects of IT surgery could be caused by mechanisms in the target tissues of insulin. The decrease in pancreatic GLP-1R levels in the MetS groups might be a compensatory response to the harmful effects of hyperinsulinemia in these groups. These results show that IT can be useful in the treatment of MetS.
C1 [Tunc-Ata, Melek; Altintas, Fatih; Kucukatay, Vural] Pamukkale Univ, Dept Physiol, Med Fac, TR-20160 Denizli, Turkey.
   [Senol, Hande] Pamukkale Univ, Dept Biostat, Med Fac, TR-20160 Denizli, Turkey.
   [Nizamoglu, Erol] Akdeniz Univ, Dept Physiol, Med Fac, TR-20160 Antalya, Turkey.
C3 Pamukkale University; Pamukkale University; Akdeniz University
RP Kucukatay, V (corresponding author), Pamukkale Univ, Dept Physiol, Med Fac, TR-20160 Denizli, Turkey.
EM melekt@pau.edu.tr; faltintas@pau.edu.tr; hsenol@pau.edu.tr;
   enizam@akdeniz.edu.tr; vkucukatay@pau.edu.tr
RI Kucukatay, Vural/ABI-6427-2020; Altintas, Fatih/ABF-5161-2021
OI Altintas, Fatih/0000-0001-8779-0110
FU Pamukkale University [2017SABE016]
FX This study is supported by funding from the Pamukkale University
   (project number 2017SABE016).
CR Avenell A., 2005, COCHRANE DB SYST REV, V18
   Barazzoni R, 2012, DIABETOLOGIA, V55, P773, DOI 10.1007/s00125-011-2396-x
   Bays HE, 2013, J CLIN LIPIDOL, V7, P304, DOI 10.1016/j.jacl.2013.04.001
   Chelikani PK, 2010, OBES SURG, V20, P1281, DOI 10.1007/s11695-010-0139-6
   Chen X, 2019, OBES SURG, V29, P3001, DOI 10.1007/s11695-019-03979-1
   Cummings BP, 2010, GASTROENTEROLOGY, V138, P2437, DOI 10.1053/j.gastro.2010.03.005
   de Luis DA, 2012, J INVEST MED, V60, P874, DOI 10.2310/JIM.0b013e3182544f9e
   Eizirik DL, 2008, ENDOCR REV, V29, P42, DOI 10.1210/er.2007-0015
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gallego-Escuredo JM, 2015, INT J OBESITY, V39, P121, DOI 10.1038/ijo.2014.76
   Giralt M, 2015, MOL CELL ENDOCRINOL, V418, P66, DOI 10.1016/j.mce.2015.09.018
   Goldstein BJ, 2005, DIABETES, V54, P311, DOI 10.2337/diabetes.54.2.311
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Hung C, 2018, BIOCHEM J, V475, P649, DOI 10.1042/BCJ20170899
   Ikezawa F, 2012, SURGERY, V151, P822, DOI 10.1016/j.surg.2011.12.026
   Karot SS, 2016, J DIABETES, V8, P629, DOI 10.1111/1753-0407.12341
   Kemmis K., 2017, NATL DIABETES STAT R
   Kohli R, 2010, AM J PHYSIOL-GASTR L, V299, pG652, DOI 10.1152/ajpgi.00221.2010
   Lehnen AM, 2013, AUTON NEUROSCI-BASIC, V176, P64, DOI 10.1016/j.autneu.2013.02.011
   Mackenzie RWA, 2014, DIABETES METAB SYNDR, V7, P55, DOI 10.2147/DMSO.S48260
   MAITER D, 1991, ENDOCRINOLOGY, V128, P1100
   Mokadem M, 2014, MOL METAB, V3, P191, DOI 10.1016/j.molmet.2013.11.010
   Nygaard EB, 2014, INT J OBESITY, V38, P183, DOI 10.1038/ijo.2013.79
   Oh TJ, 2016, OBES SURG, V26, P1287, DOI 10.1007/s11695-015-1879-0
   OLNEY JW, 1969, SCIENCE, V164, P719, DOI 10.1126/science.164.3880.719
   Patton A, 2017, DIGEST DIS, V35, P191, DOI 10.1159/000450910
   Placzkowska S., 2017, CLIN DIABETOLOGY, V6, P151
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Rosa DD, 2016, FOOD FUNCT, V7, P3390, DOI [10.1039/c6fo00339g, 10.1039/C6FO00339G]
   SASAKI F, 1994, ANAT REC, V240, P255, DOI 10.1002/ar.1092400213
   Schauer PR, 2012, NEW ENGL J MED, V366, P1567, DOI 10.1056/NEJMoa1200225
   Schoelch C, 2002, AM J PHYSIOL-ENDOC M, V283, pE604, DOI 10.1152/ajpendo.00439.2001
   Seeley RJ, 2015, CELL METAB, V21, P369, DOI 10.1016/j.cmet.2015.01.001
   Speck M, 2011, AM J PHYSIOL-ENDOC M, V300, pE923, DOI 10.1152/ajpendo.00422.2010
   Strader AD, 2009, OBES SURG, V19, P96, DOI 10.1007/s11695-008-9754-x
   Tsuchiya T, 1996, AM J PHYSIOL-GASTR L, V271, pG681, DOI 10.1152/ajpgi.1996.271.4.G681
   van den Hoek AM, 2004, DIABETES, V53, P1949, DOI 10.2337/diabetes.53.8.1949
   Wang WF, 2015, ENDOCRINE, V49, P119, DOI 10.1007/s12020-014-0433-5
   Werner Wiebke, 2014, BMC Res Notes, V7, P702, DOI 10.1186/1756-0500-7-702
   Woods M, 2011, BRIT J SURG, V98, P686, DOI 10.1002/bjs.7400
   Yan KM, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00191
   Zhu HL, 2018, GASTROENTEROL REP, V6, P291, DOI 10.1093/gastro/goy027
NR 42
TC 5
Z9 5
U1 1
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD FEB 1
PY 2021
VL 266
AR 118846
DI 10.1016/j.lfs.2020.118846
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA PV5TE
UT WOS:000610049400008
PM 33309719
DA 2025-06-11
ER

PT J
AU Kallio, P
   Kolehmainen, M
   Laaksonen, DE
   Kekäläinen, J
   Salopuro, T
   Sivenius, K
   Pulkkinen, L
   Mykkänen, HM
   Niskanen, L
   Uusitupa, M
   Poutanen, KS
AF Kallio, Petteri
   Kolehmainen, Marjukka
   Laaksonen, David E.
   Kekalainen, Jani
   Salopuro, Titta
   Sivenius, Katariina
   Pulkkinen, Leena
   Mykkanen, Hannu M.
   Niskanen, Leo
   Uusitupa, Matti
   Poutanen, Kaisa S.
TI Dietary carbohydrate modification induces alterations in gene expression
   in abdominal subcutaneous adipose tissue in persons with the metabolic
   syndrome:: the FUNGENUT Study
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE gene-nutrient interactions; metabolic syndrome; insulin resistance;
   microarray; adipose tissue; diet intervention; insulinernic response;
   rye; oat; wheat
ID POSTPRANDIAL INSULIN-RESPONSE; IMPAIRED GLUCOSE-TOLERANCE; FAT-CELLS;
   GLYCEMIC INDEX; RYE BREAD; SENSITIVITY; SECRETION; FIBER; INFLAMMATION;
   RESISTANCE
AB Background: Diets rich in whole-grain cereals and foods with a low glycemic index may protect against type 2 diabetes, but the underlying molecular mechanisms are unknown.
   Objective: The main objective was to test whether 2 different carbohydrate modifications-a rye-pasta diet characterized by a low postprandial insulin response and an oat-wheat-potato diet characterized by a high postprandial insulin response-affect gene expression in subcutaneous adipose tissue (SAT) in persons with the metabolic syndrome.
   Design: We assessed the effect of carbohydrate modification on SAT gene expression in 47 subjects [24 men and 23 women with a mean (+/- SD) age of 55 +/- 6 y] with the features of the metabolic syndrome in a parallel study design. The subjects had a mean ( SD) body mass index (kg/m(2)) of 32.1 +/- 3.8 and a 2-h plasma glucose concentration of 8.0 +/- 2.3 mmol/L. Adipose tissue biopsies were performed, and oral-glucose-tolerance tests and other biochemical measurements were conducted before and after the intervention. Results: We detected 71 down-regulated genes in the rye-pasta group, including genes linked to insulin signaling and apoptosis. In contrast, the 12-wk oat-wheat-potato diet up-regulated 62 genes related to stress, cytokine-chemokine-mediated immunity, and the interleukin pathway. The insulinogenic index improved after the rye-pasta diet (P = 0.004) but not after the oat-wheat-potato diet. Body weight was unchanged in both groups.
   Conclusions: Dietary carbohydrate modification with rye and pasta or oat, wheat, and potato differentially modulates the gene expression profile in abdominal subcutaneous adipose tissue, even in the absence of weight loss.
C1 Univ Kuopio, Dept Clin Nutr, Food & Hlth Res Ctr, FIN-70211 Kuopio, Finland.
   Univ Kuopio, Dept Med, FIN-70211 Kuopio, Finland.
   Univ Kuopio, Dept Comp Sci, FIN-70211 Kuopio, Finland.
   VTT, Espoo, Finland.
C3 University of Eastern Finland; University of Eastern Finland; University
   of Eastern Finland; VTT Technical Research Center Finland
RP Kolehmainen, M (corresponding author), Univ Kuopio, Dept Clin Nutr, Food & Hlth Res Ctr, FIN-70211 Kuopio, Finland.
EM marjukka.kolehmainen@uku.fi
RI Uusitupa, Matti/AAX-4929-2020; Kolehmainen, Marjukka/JFS-1563-2023
OI Kolehmainen, Marjukka/0000-0002-3770-2538
CR Bachoo RM, 2004, P NATL ACAD SCI USA, V101, P8384, DOI 10.1073/pnas.0402140101
   Björntorp P, 2000, BRIT J NUTR, V83, pS49, DOI 10.1017/S0007114500000957
   Blüher M, 2002, DEV CELL, V3, P25, DOI 10.1016/S1534-5807(02)00199-5
   Chan SSY, 2005, J CLIN ENDOCR METAB, V90, P6588, DOI 10.1210/jc.2005-0595
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Clément K, 2004, FASEB J, V18, P1657, DOI 10.1096/fj.04-2204com
   Dahlman I, 2005, AM J CLIN NUTR, V81, P1275
   Dennis G, 2003, GENOME BIOL, V4, DOI 10.1186/gb-2003-4-9-r60
   Frühbeck G, 2001, AM J PHYSIOL-ENDOC M, V280, pE827, DOI 10.1152/ajpendo.2001.280.6.E827
   Gómez-Ambrosi J, 2004, FASEB J, V18, P215, DOI 10.1096/fj.03-0591fje
   Han TS, 2002, DIABETES CARE, V25, P2016, DOI 10.2337/diacare.25.11.2016
   Juntunen KS, 2003, AM J CLIN NUTR, V78, P957, DOI 10.1093/ajcn/78.5.957
   Juntunen KS, 2003, AM J CLIN NUTR, V77, P385
   Juntunen KS, 2002, AM J CLIN NUTR, V75, P254, DOI 10.1093/ajcn/75.2.254
   Kahn BB, 1998, CELL, V92, P593, DOI 10.1016/S0092-8674(00)81125-3
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   Kim S, 2000, J NUTR, V130, p3110S
   Kolehmainen M, 2002, INT J OBESITY, V26, P6, DOI 10.1038/sj.ijo.0801858
   Kregel KC, 2002, J APPL PHYSIOL, V92, P2177, DOI 10.1152/japplphysiol.01267.2001
   Laaksonen DE, 2004, ANN MED, V36, P332, DOI 10.1080/07853890410031849
   Laaksonen DE, 2003, EUR J ENDOCRINOL, V149, P601, DOI 10.1530/eje.0.1490601
   Laaksonen DE, 2005, AM J CLIN NUTR, V82, P1218, DOI 10.1093/ajcn/82.6.1218
   Laaksonen DE, 2002, AM J EPIDEMIOL, V156, P1070, DOI 10.1093/aje/kwf145
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Leinonen K, 1999, EUR J CLIN NUTR, V53, P262, DOI 10.1038/sj.ejcn.1600716
   Leong MLL, 2003, J BIOL CHEM, V278, P5871, DOI 10.1074/jbc.M211649200
   Li C, 2001, P NATL ACAD SCI USA, V98, P31, DOI 10.1073/pnas.011404098
   Ludwig DS, 2002, JAMA-J AM MED ASSOC, V287, P2414, DOI 10.1001/jama.287.18.2414
   Lyssenko V, 2005, DIABETES, V54, P166, DOI 10.2337/diabetes.54.1.166
   Martin ASG, 2006, AM J CLIN NUTR, V83, p461S, DOI 10.1093/ajcn/83.2.461s
   Millenaar FF, 2006, BMC BIOINFORMATICS, V7, DOI 10.1186/1471-2105-7-137
   OHISALO JJ, 1992, CLIN SCI, V83, P589, DOI 10.1042/cs0830589
   Osei K, 2004, DIABETES CARE, V27, P1439, DOI 10.2337/diacare.27.6.1439
   Qi L, 2006, DIABETES CARE, V29, P207, DOI 10.2337/diacare.29.02.06.dc05-1903
   Qi MS, 2005, J CELL SCI, V118, P3569, DOI 10.1242/jcs.02470
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Reynisdottir S, 1997, J CLIN ENDOCR METAB, V82, P4162, DOI 10.1210/jc.82.12.4162
   Robertson MD, 2005, AM J CLIN NUTR, V82, P559, DOI 10.1093/ajcn/82.3.559
   RODBELL M, 1964, J BIOL CHEM, V239, P375
   Salmeron J, 1997, DIABETES CARE, V20, P545, DOI 10.2337/diacare.20.4.545
   Schulze MB, 2004, AM J CLIN NUTR, V80, P348, DOI 10.1093/ajcn/80.2.348
   Smith U, 2002, INT J OBESITY, V26, P897, DOI 10.1038/sj.ijo.0802028
   Thomas PD, 2003, GENOME RES, V13, P2129, DOI 10.1101/gr.772403
   Tusher VG, 2001, P NATL ACAD SCI USA, V98, P5116, DOI 10.1073/pnas.091062498
   Uusitupa M, 2003, DIABETES, V52, P2532, DOI 10.2337/diabetes.52.10.2532
   WOLEVER TMS, 1995, DIABETES CARE, V18, P962, DOI 10.2337/diacare.18.7.962
NR 46
TC 102
Z9 117
U1 0
U2 17
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD MAY
PY 2007
VL 85
IS 5
BP 1417
EP 1427
DI 10.1093/ajcn/85.5.1417
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 168GN
UT WOS:000246511400033
PM 17490981
OA Bronze
DA 2025-06-11
ER

PT J
AU Wennersberg, MH
   Smedman, A
   Turpeinen, AM
   Retterstol, K
   Tengblad, S
   Lipre, E
   Aro, A
   Mutanen, P
   Seljeflot, I
   Basu, S
   Pedersen, JI
   Mutanen, M
   Vessby, B
AF Wennersberg, Marianne Hauge
   Smedman, Annika
   Turpeinen, Anu M.
   Retterstol, Kjetil
   Tengblad, Siv
   Lipre, Endla
   Aro, Antti
   Mutanen, Pertti
   Seljeflot, Ingebjorg
   Basu, Samar
   Pedersen, Jan I.
   Mutanen, Marja
   Vessby, Bengt
TI Dairy products and metabolic effects in overweight men and women:
   results from a 6-mo intervention study
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID CORONARY-HEART-DISEASE; BLOOD-PRESSURE; DIETARY CALCIUM; SATURATED FAT;
   NUTRIENT INTAKE; SERUM-LIPIDS; RISK-FACTORS; BODY-WEIGHT; MILK-FAT;
   CHOLESTEROL
AB Background: Some epidemiologic studies have suggested inverse relations between intake of dairy products and components of the metabolic syndrome.
   Objective: The objective was to investigate the effects of an increased intake of dairy products in persons with a habitually low intake on body composition and factors related to the metabolic syndrome.
   Design: Middle-aged overweight subjects (n = 121) with traits of the metabolic syndrome were recruited in Finland, Norway, and Sweden and randomly assigned into milk or control groups. The milk group was instructed to consume 3-5 portions of dairy products daily. The control group maintained their habitual diet. Clinical investigations were conducted on admission and after 6 mo.
   Results: There were no significant differences between changes in body weight or body composition, blood pressure, markers of inflammation, endothelial function, adiponectin, or oxidative stress in the milk and the control groups. There was a modest unfavorable increase in serum cholesterol concentrations in the milk group (P = 0.043). Among participants with a low calcium intake at baseline (<700 mg/d), there was a significant treatment effect for waist circumference (P = 0.003) and sagittal abdominal diameter (P = 0.034). When the sexes were analyzed separately, leptin increased (P = 0.045) and vascular cell adhesion molecule-1 decreased (P = 0.001) in women in the milk group.
   Conclusions: This study gives no clear support to the hypothesis that a moderately increased intake of dairy products beneficially affects aspects of the metabolic syndrome. The apparently positive effects on waist circumference and sagittal abdominal diameter in subjects with a low calcium intake suggest a possible threshold in relation to effects on body composition. Am J Clin Nutr 2009;90:960-8.
C1 [Smedman, Annika; Tengblad, Siv; Basu, Samar; Vessby, Bengt] Uppsala Univ, Dept Publ Hlth & Caring Sci, S-75125 Uppsala, Sweden.
   [Turpeinen, Anu M.; Lipre, Endla; Mutanen, Marja] Univ Helsinki, Div Nutr, Dept Appl Chem & Microbiol, Helsinki, Finland.
   [Aro, Antti] Natl Inst Hlth & Welf, Helsinki, Finland.
   [Wennersberg, Marianne Hauge; Pedersen, Jan I.] Univ Oslo, Dept Nutr, Oslo, Norway.
   [Wennersberg, Marianne Hauge; Retterstol, Kjetil] Oslo Univ Hosp, Dept Med, Rikshosp, Lipid Clin, Oslo, Norway.
   [Seljeflot, Ingebjorg] Ullevaal Univ Hosp, Dept Cardiol, Oslo, Norway.
C3 Uppsala University; University of Helsinki; Finland National Institute
   for Health & Welfare; University of Oslo; University of Oslo; National
   Hospital Norway; University of Oslo
RP Vessby, B (corresponding author), Uppsala Univ, Dept Publ Hlth & Caring Sci, POB 609, S-75125 Uppsala, Sweden.
EM bengt.vessby@pubcare.uu.se
FU Finnish Ministry of Agriculture and Forestry; National Research Council
   of Norway; Information Office for Milk Products, Norway; Swedish
   Farmer's Foundation for Agricultural Research; Swedish Dairy Association
FX Supported by the Finnish Ministry of Agriculture and Forestry; the
   National Research Council of Norway; the Information Office for Milk
   Products, Norway; the Swedish Farmer's Foundation for Agricultural
   Research; and the Swedish Dairy Association.
CR Agerholm-Larsen L, 2000, EUR J CLIN NUTR, V54, P856, DOI 10.1038/sj.ejcn.1601104
   Allender PS, 1996, ANN INTERN MED, V124, P825, DOI 10.7326/0003-4819-124-9-199605010-00007
   Alonso A, 2005, AM J CLIN NUTR, V82, P972, DOI 10.1093/ajcn/82.5.972
   Appel LJ, 1997, NEW ENGL J MED, V336, P1117, DOI 10.1056/NEJM199704173361601
   ARTAUDWILD SM, 1993, CIRCULATION, V88, P2771, DOI 10.1161/01.CIR.88.6.2771
   Azadbakht L, 2005, AM J CLIN NUTR, V82, P523, DOI 10.1093/ajcn/82.3.523
   Barba G, 2006, NUTR METAB CARDIOVAS, V16, P445, DOI 10.1016/j.numecd.2006.04.004
   Barr SI, 2003, J NUTR, V133, p245S
   Barr SI, 2000, J AM DIET ASSOC, V100, P810, DOI 10.1016/S0002-8223(00)00236-4
   Basu S, 1998, PROSTAG LEUKOTR ESS, V58, P319, DOI 10.1016/S0952-3278(98)90042-4
   Biong AS, 2006, EUR J LIPID SCI TECH, V108, P827, DOI 10.1002/ejlt.200600044
   Biong AS, 2004, BRIT J NUTR, V92, P791, DOI 10.1079/BJN20041257
   BUONOPANE GJ, 1992, J AM COLL NUTR, V11, P56
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Couillard C, 2006, NUTRITION, V22, P600, DOI 10.1016/j.nut.2006.03.007
   Dickinson HO, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004639
   Givens DI, 2008, P NUTR SOC, V67, P419, DOI 10.1017/S0029665108008707
   Gunther CW, 2005, AM J CLIN NUTR, V81, P751, DOI 10.1093/ajcn/81.4.751
   Haug A, 2007, LIPIDS HEALTH DIS, V6, DOI 10.1186/1476-511X-6-25
   Hu FB, 2001, J AM COLL NUTR, V20, P5, DOI 10.1080/07315724.2001.10719008
   Jauhiainen T, 2007, J NUTR, V137, p825S, DOI 10.1093/jn/137.3.825S
   KATAN MB, 1994, AM J CLIN NUTR, V60, p1017S, DOI 10.1093/ajcn/60.6.1017S
   Kennedy A, 2009, J NUTR, V139, P1, DOI 10.3945/jn.108.098269
   Keogh JB, 2005, ARTERIOSCL THROM VAS, V25, P1274, DOI 10.1161/01.ATV.0000163185.28245.a1
   KrisEtherton PM, 1997, AM J CLIN NUTR, V65, P1628, DOI 10.1093/ajcn/65.5.1628S
   Lanou AJ, 2008, NUTR REV, V66, P272, DOI 10.1111/j.1753-4887.2008.00032.x
   Major GC, 2008, OBES REV, V9, P428, DOI 10.1111/j.1467-789X.2007.00465.x
   MCCARRON DA, 1984, SCIENCE, V224, P1392, DOI 10.1126/science.6729459
   MCCARRON DA, 1991, AM J CLIN NUTR, V54, pS215, DOI 10.1093/ajcn/54.1.215S
   Nestel PJ, 2005, EUR J CLIN NUTR, V59, P1059, DOI 10.1038/sj.ejcn.1602211
   Pereira MA, 2002, JAMA-J AM MED ASSOC, V287, P2081, DOI 10.1001/jama.287.16.2081
   Pfeuffer M, 2007, OBES REV, V8, P109, DOI 10.1111/j.1467-789X.2006.00265.x
   Ren J, 2004, J ENDOCRINOL, V181, P1, DOI 10.1677/joe.0.1810001
   Renaud S, 2001, Public Health Nutr, V4, P459
   Ruidavets JB, 2006, J HYPERTENS, V24, P671, DOI 10.1097/01.hjh.0000217849.10831.16
   SCHOELLER DA, 1995, METABOLISM, V44, P18, DOI 10.1016/0026-0495(95)90204-X
   Smedman AEM, 1999, AM J CLIN NUTR, V69, P22
   Snijder MB, 2008, OBESITY, V16, P706, DOI 10.1038/oby.2007.93
   St-Onge MP, 2000, AM J CLIN NUTR, V71, P674, DOI 10.1093/ajcn/71.3.674
   Summers LKM, 2002, DIABETOLOGIA, V45, P369, DOI 10.1007/s00125-001-0768-3
   Szoke E, 2008, DIABETES CARE, V31, P539, DOI 10.2337/dc07-1443
   Teegarden D, 2005, J NUTR, V135, P2749, DOI 10.1093/jn/135.12.2749
   Tholstrup T, 2004, J AM COLL NUTR, V23, P169, DOI 10.1080/07315724.2004.10719358
   TURPEINEN O, 1979, CIRCULATION, V59, P1
   VANBERESTEIJN ECH, 1990, J INTERN MED, V228, P477, DOI 10.1111/j.1365-2796.1990.tb00266.x
   Vessby B, 2001, DIABETOLOGIA, V44, P312, DOI 10.1007/s001250051620
   Wolk A, 1998, AM J CLIN NUTR, V68, P291, DOI 10.1093/ajcn/68.2.291
   Wolk A, 2001, J NUTR, V131, P828, DOI 10.1093/jn/131.3.828
   Xu JY, 2008, NUTRITION, V24, P933, DOI 10.1016/j.nut.2008.04.004
   Zemel MB, 2004, OBES RES, V12, P582, DOI 10.1038/oby.2004.67
NR 50
TC 131
Z9 147
U1 0
U2 12
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD OCT 1
PY 2009
VL 90
IS 4
BP 960
EP 968
DI 10.3945/ajcn.2009.27664
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 496GC
UT WOS:000269956700011
PM 19710195
DA 2025-06-11
ER

PT J
AU Conti, FF
   Brito, JD
   Bernardes, N
   Dias, DD
   Malfitano, C
   Morris, M
   Llesuy, SF
   Irigoyen, MC
   De Angelis, K
AF Conti, Filipe Fernandes
   Brito, Janaina de Oliveira
   Bernardes, Nathalia
   Dias, Danielle da Silva
   Malfitano, Christiane
   Morris, Mariana
   Francisca Llesuy, Susana
   Irigoyen, Maria-Claudia
   De Angelis, Katia
TI Positive effect of combined exercise training in a model of metabolic
   syndrome and menopause: autonomic, inflammatory, and oxidative stress
   evaluations
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE exercise training; menopause; metabolic syndrome; blood pressure
   variability; inflammation; oxidative stress
ID RESISTANCE EXERCISE; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE;
   CLINICAL-CARDIOLOGY; INSULIN-RESISTANCE; BENEFITS; INDIVIDUALS;
   DYSFUNCTION; IMPROVEMENT; COUNCIL
AB It is now well established that after menopause cardiometabolic disorders become more common. Recently, resistance exercise has been recommended as a complement to aerobic (combined training, CT) for the treatment of cardiometabolic diseases. The aim of this study was to evaluate the effects of CT in hypertensive ovariectomized rats undergoing fructose overload in blood pressure variability (BPV), inflammation, and oxidative stress parameters. Female rats were divided into the following groups (n = 8/group): sedentary normotensive Wistar rats (C), and sedentary (FHO) or trained (FHOT) ovariectomized spontaneously hypertensive rats undergoing and fructose overload. CT was performed on a treadmill and ladder adapted to rats in alternate days (8 wk; 40-60% maximal capacity). Arterial pressure (AP) was directly measured. Oxidative stress and inflammation were measured on cardiac and renal tissues. The association of risk factors (hypertension + ovariectomy + fructose) promoted increase in insulin resistance, mean AP (FHO: 174 +/- 4 vs. C: 108 +/- 1 mmHg), heart rate (FHO: 403 +/- 12 vs. C: 352 +/- 11 beats/min), BPV, cardiac inflammation (tumor necrosis factor-alpha-FHO: 65.8 +/- 9.9 vs. C: 23.3 +/- 4.3 pg/mg protein), and oxidative stress cardiac and renal tissues. However, CT was able to reduce mean AP (FHOT: 158 +/- 4 mmHg), heart rate (FHOT: 303 +/- 5 beats/min), insulin resistance, and sympathetic modulation. Moreover, the trained rats presented increased nitric oxide bioavailability, reduced tumor necrosis factor-alpha (FHOT: 33.1 +/- 4.9 pg/mg protein), increased IL-10 in cardiac tissue and reduced lipoperoxidation, and increased antioxidant defenses in cardiac and renal tissues. In conclusion, the association of risk factors promoted an additional impairment in metabolic, cardiovascular, autonomic, inflammatory, and oxidative stress parameters and combined exercise training was able to attenuate these dysfunctions.
C1 [Conti, Filipe Fernandes; Brito, Janaina de Oliveira; Bernardes, Nathalia; Dias, Danielle da Silva; Malfitano, Christiane; De Angelis, Katia] Univ Nove de Julho UNINOVE, Lab Translat Physiol, Sao Paulo, Brazil.
   [Bernardes, Nathalia; Irigoyen, Maria-Claudia] Univ Sao Paulo, Sch Med, Heart Inst InCor, Hypertens Unit, Sao Paulo, Brazil.
   [Morris, Mariana] Nova SE Univ, Inst Neuroimmune Med, Ft Lauderdale, FL 33314 USA.
   [Francisca Llesuy, Susana] Univ Buenos Aires, Buenos Aires, DF, Argentina.
C3 Universidade Nove de Julho; Universidade de Sao Paulo; Nova Southeastern
   University; University of Buenos Aires
RP De Angelis, K (corresponding author), Univ Nove de Julho, Lab Translat Physiol, Rua Vergueiro,235-249 Liberdade, Sao Paulo, SP, Brazil.
EM prof.kangelis@uninove.br
RI Conti, Filipe/C-3060-2013; da Silva Dias, Danielle/AAN-7618-2020;
   Malfitano, Christiane/I-2701-2013; Bernardes, Nathalia/L-7460-2015;
   Irigoyen, maria Claudia/N-6880-2014; DE ANGELIS, KATIA/I-6098-2016
OI Francisca Llesuy, Susana/0000-0001-6818-051X; Irigoyen, maria
   Claudia/0000-0003-2097-3662; DE ANGELIS, KATIA/0000-0002-3640-9049
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES);
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
   [479766/2011-8]; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
   [2012/20141-5, 2011/15828-9, 2010/171884]; CAPES
   [PVE-88881.062178/2014-01]; CNPq
FX This study was supported by Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior (CAPES), Conselho Nacional de Desenvolvimento Cientifico
   e Tecnologico (CNPq, 479766/2011-8), and Fundacao de Amparo a Pesquisa
   do Estado de Sao Paulo (2012/20141-5; 2011/15828-9; 2010/171884); CAPES
   (PVE-88881.062178/2014-01). Maria-Claudia Irigoyen and Katia De Angelis
   are recipients of CNPq Fellowship.
CR Aiello EJ, 2004, MENOPAUSE, V11, P382, DOI 10.1097/01.GME.0000113932.56832.27
   ANDERSON ME, 1985, METHOD ENZYMOL, V113, P548
   [Anonymous], 1984, METHOD ENZYMOL
   Basciano Heather, 2005, Nutr Metab (Lond), V2, P5, DOI 10.1186/1743-7075-2-5
   Bertagnolli M, 2006, J HYPERTENS, V24, P2437, DOI 10.1097/01.hjh.0000251905.08547.17
   BONORA E, 1989, J CLIN ENDOCR METAB, V68, P374, DOI 10.1210/jcem-68-2-374
   Borovikova LV, 2000, NATURE, V405, P458, DOI 10.1038/35013070
   Brito JO, 2008, BRAZ J MED BIOL RES, V41, P804, DOI 10.1590/S0100-879X2008005000030
   Buege J A, 1978, Methods Enzymol, V52, P302
   CHENG Y, 1992, ACTA PHARM SINIC, V13, P235
   Clarkson P, 1999, J AM COLL CARDIOL, V33, P1379, DOI 10.1016/S0735-1097(99)00036-4
   Claudino MA, 2004, UROLOGY, V63, P1004, DOI 10.1016/j.urology.2003.11.034
   Condezo-Hoyos L, 2012, J HYPERTENS, V30, P1185, DOI 10.1097/HJH.0b013e328353824b
   Cornelissen VA, 2011, HYPERTENSION, V58, P950, DOI 10.1161/HYPERTENSIONAHA.111.177071
   De Angelis K, 2012, AM J PHYSIOL-REG I, V302, pR950, DOI 10.1152/ajpregu.00450.2011
   De Angelis K, 2009, AUTON NEUROSCI-BASIC, V145, P3, DOI 10.1016/j.autneu.2008.10.013
   DeAngelis KLD, 1997, HYPERTENSION, V30, P767, DOI 10.1161/01.HYP.30.3.767
   Evelson P, 2001, ARCH BIOCHEM BIOPHYS, V388, P261, DOI 10.1006/abbi.2001.2292
   Fain JN, 2004, ENDOCRINOLOGY, V145, P2273, DOI 10.1210/en.2003-1336
   Farah V, 2006, AUTON NEUROSCI-BASIC, V130, P41, DOI 10.1016/j.autneu.2006.05.006
   FLECHA BG, 1991, FREE RADICAL BIO MED, V10, P93
   Flues K, 2010, MATURITAS, V65, P267, DOI 10.1016/j.maturitas.2009.11.007
   Granger DL, 1999, METHOD ENZYMOL, V301, P49
   Green JS, 2002, MED SCI SPORT EXER, V34, P74, DOI 10.1097/00005768-200201000-00013
   Higashi Y, 1999, HYPERTENSION, V33, P591, DOI 10.1161/01.HYP.33.1.591
   Howlett KF, 2002, DIABETES, V51, P479, DOI 10.2337/diabetes.51.2.479
   Irigoyen MC, 2005, HYPERTENSION, V46, P998, DOI 10.1161/01.HYP.0000176238.90688.6b
   IRIGOYEN MC, 1995, HYPERTENSION, V26, P1111, DOI 10.1161/01.HYP.26.6.1111
   Kamide K, 2002, AM J HYPERTENS, V15, P66, DOI 10.1016/S0895-7061(01)02232-4
   Kingwell Bronwyn A., 1997, American Journal of Physiology, V272, pH1070
   Kraemer WJ, 2004, MED SCI SPORT EXER, V36, P674, DOI 10.1249/01.MSS.0000121945.36635.61
   Kuo TBJ, 1999, AM J PHYSIOL-HEART C, V277, pH2233, DOI 10.1152/ajpheart.1999.277.6.H2233
   Laville M, 2009, OBES REV, V10, P24, DOI 10.1111/j.1467-789X.2008.00562.x
   Luciano E, 2002, EUR J ENDOCRINOL, V147, P149, DOI 10.1530/eje.0.1470149
   MANCIA G, 1986, HYPERTENSION, V8, P147, DOI 10.1161/01.HYP.8.2.147
   MANCIA G, 1983, CIRC RES, V53, P96, DOI 10.1161/01.RES.53.1.96
   MARKLUND SL, 1985, MUTAT RES, V148, P129, DOI 10.1016/0027-5107(85)90216-7
   Moraes-Silva IC, 2013, J APPL PHYSIOL, V114, P786, DOI 10.1152/japplphysiol.00586.2012
   PICK E, 1980, J IMMUNOL METHODS, V38, P161, DOI 10.1016/0022-1759(80)90340-3
   Pollock ML, 2000, CIRCULATION, V101, P828, DOI 10.1161/01.CIR.101.7.828
   Renna NF, 2013, INT J HYPERTENS, V2013, DOI 10.1155/2013/420979
   REZNICK AZ, 1994, METHOD ENZYMOL, V233, P357
   Rodrigues B, 2007, CARDIOVASC DIABETOL, V6, DOI 10.1186/1475-2840-6-38
   Sanches IC, 2014, INT J SPORTS MED, V35, P323, DOI 10.1055/s-0033-1351254
   Sanches IC, 2012, MENOPAUSE, V19, P562, DOI 10.1097/gme.0b013e3182358c9c
   Soares PPDA, 2004, AUTON NEUROSCI-BASIC, V113, P24, DOI 10.1016/j.autneu.2004.05.002
   Sowers MR, 1995, EPIDEMIOL REV, V17, P287, DOI 10.1093/oxfordjournals.epirev.a036194
   Van Gaal LF, 2006, NATURE, V444, P875, DOI 10.1038/nature05487
   Williams AD, 2011, J SCI MED SPORT, V14, P331, DOI 10.1016/j.jsams.2011.02.011
   Williams MA, 2007, CIRCULATION, V116, P572, DOI 10.1161/CIRCULATIONAHA.107.185214
   Wojtaszewski JFP, 1999, J CLIN INVEST, V104, P1257, DOI 10.1172/JCI7961
NR 51
TC 49
Z9 56
U1 0
U2 10
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD DEC 15
PY 2015
VL 309
IS 12
BP R1532
EP R1539
DI 10.1152/ajpregu.00076.2015
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA CZ7PY
UT WOS:000367293000008
PM 26423710
OA Green Published
DA 2025-06-11
ER

PT J
AU Solini, A
   Menini, S
   Rossi, C
   Ricci, C
   Santini, E
   Fantauzzi, CB
   Iacobini, C
   Pugliese, G
AF Solini, Anna
   Menini, Stefano
   Rossi, Chiara
   Ricci, Carlo
   Santini, Eleonora
   Fantauzzi, Claudia Blasetti
   Iacobini, Carla
   Pugliese, Giuseppe
TI The purinergic 2X7 receptor participates in renal
   inflammation and injury induced by high-fat diet: possible role of NLRP3
   inflammasome activation
SO JOURNAL OF PATHOLOGY
LA English
DT Article
DE renal disease; metabolic syndrome; type 2 diabetes; P2X(7) receptor;
   NLRP3
ID NF-KAPPA-B; METABOLIC SYNDROME; KIDNEY-DISEASE; P2X RECEPTORS;
   INSULIN-RESISTANCE; LIPID-METABOLISM; MESANGIAL CELLS; ADIPOSE-TISSUE;
   OBESE MICE; GLOMERULOSCLEROSIS
AB Renal disease associated with type 2 diabetes and the metabolic syndrome is characterized by a distinct inflammatory phenotype. The purinergic 2X(7) receptor (P2X(7)R) and the nucleotide-binding and oligomerization domain-like receptor containing a pyrin domain 3 (NLRP3) inflammasome have been separately shown to play a role in two models of non-metabolic chronic kidney disease. Moreover, the NLRP3 inflammasome has been implicated in chronic low-grade sterile inflammation characterizing metabolic disorders, though the mechanism(s) involved in inflammasome activation under these conditions are still unknown. We investigated the role of P2X(7)R (through activation of the NLRP3 inflammasome) in renal inflammation and injury induced by a high-fat diet, an established model of the metabolic syndrome. On a high-fat diet, mice lacking P2X(7)R developed attenuated renal functional and structural alterations as well as reduced inflammation, fibrosis, and oxidative/carbonyl stress, as compared with wild-type animals, in the absence of significant differences in metabolic parameters. This was associated with blunted up-regulation of the NLRP3 inflammasome components NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), pro-caspase 1, pro-interleukin (IL)-1, and pro-IL-18, as well as reduced inflammasome activation, as evidenced by decreased formation of mature caspase 1, whereas mature IL-1 and IL-18 were not detected. Up-regulated expression of NLRP3 and pro-caspase 1, post-translational processing of pro-caspase-1, and release of IL-18 in response to lipopolysaccharide+2(3)-O-(4-benzoylbenzoyl)ATP were attenuated by P2X(7)R silencing in cultured mouse podocytes. Protein and mRNA expression of P2X(7)R, NLRP3, and ASC were also increased in kidneys from subjects with type 2 diabetes and the metabolic syndrome, showing histologically documented renal disease. These data provide evidence of a major role for the purinergic system, at least in part through activation of the NLRP3 inflammasome, in the process driving metabolic' renal inflammation and injury and identify P2X(7)R and NLRP3 as novel therapeutic targets. Copyright (c) 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
C1 [Solini, Anna; Rossi, Chiara; Santini, Eleonora] Univ Pisa, Dept Clin & Expt Med, I-56100 Pisa, Italy.
   [Menini, Stefano; Ricci, Carlo; Fantauzzi, Claudia Blasetti; Iacobini, Carla; Pugliese, Giuseppe] Univ Roma La Sapienza, Dept Clin & Mol Med, Rome, Italy.
C3 University of Pisa; Sapienza University Rome
RP Solini, A (corresponding author), Univ Pisa, Dept Clin & Expt Med, Via Roma 67, I-56100 Pisa, Italy.
EM anna.solini@med.unipi.it
RI Rossi, Chiara/AAI-2306-2020; Pugliese, Giuseppe/G-8776-2012; Solini,
   Anna/K-4666-2016; Menini, Stefano/G-1130-2010
OI Pugliese, Giuseppe/0000-0003-1574-0397; ROSSI,
   CHIARA/0000-0002-5724-268X; Solini, Anna/0000-0002-7855-8253; Menini,
   Stefano/0000-0001-7328-2385
FU 'La Sapienza' University; Diabetes, Endocrinology and Metabolism
   Foundation, Rome, Italy; Research Foundation of the Italian Society of
   Diabetology (Fo.Ri.SID)
FX This work was supported by grants from 'La Sapienza' University and the
   Diabetes, Endocrinology and Metabolism Foundation, Rome, Italy. Chiara
   Rossi was the recipient of a fellowship from the Research Foundation of
   the Italian Society of Diabetology (Fo.Ri.SID) for this research.
CR Anders HJ, 2011, J AM SOC NEPHROL, V22, P1007, DOI 10.1681/ASN.2010080798
   [Anonymous], 2010, DIABETES CARE S1
   Babelova A, 2009, J BIOL CHEM, V284, P24035, DOI 10.1074/jbc.M109.014266
   Bauernfeind F, 2011, J IMMUNOL, V187, P613, DOI 10.4049/jimmunol.1100613
   Bours Martijn Jan Leo, 2011, Front Biosci (Schol Ed), V3, P1443
   Buraczynska M, 2006, CYTOKINE, V36, P167, DOI 10.1016/j.cyto.2006.11.011
   CASTELLI WP, 1986, JAMA-J AM MED ASSOC, V256, P2835, DOI 10.1001/jama.256.20.2835
   Cavelti-Weder C, 2012, DIABETES CARE, V35, P1654, DOI 10.2337/dc11-2219
   Chatterjee S, 2012, FREE RADICAL BIO MED, V52, P1666, DOI 10.1016/j.freeradbiomed.2012.02.010
   Dalrymple LS, 2008, AM J NEPHROL, V28, P723, DOI 10.1159/000127980
   Deji N, 2009, AM J PHYSIOL-RENAL, V296, pF118, DOI 10.1152/ajprenal.00110.2008
   Duewell P, 2010, NATURE, V464, P1357, DOI 10.1038/nature08938
   Ferrari D, 1997, J CELL BIOL, V139, P1635, DOI 10.1083/jcb.139.7.1635
   Glas R, 2009, DIABETOLOGIA, V52, P1579, DOI 10.1007/s00125-009-1349-0
   Gonçalves RG, 2006, KIDNEY INT, V70, P1599, DOI 10.1038/sj.ki.5001804
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Harada H, 2000, KIDNEY INT, V57, P949, DOI 10.1046/j.1523-1755.2000.00911.x
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Iacobini C, 2005, AM J PHYSIOL-RENAL, V289, pF611, DOI 10.1152/ajprenal.00435.2004
   Iacobini C, 2009, J PATHOL, V218, P360, DOI 10.1002/path.2536
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jiang T, 2005, J BIOL CHEM, V280, P32317, DOI 10.1074/jbc.M500801200
   Korcok J, 2004, J BONE MINER RES, V19, P642, DOI 10.1359/JBMR.040108
   Krane V, 2011, NAT REV NEPHROL, V7, P385, DOI 10.1038/nrneph.2011.62
   Kume S, 2007, J AM SOC NEPHROL, V18, P2715, DOI 10.1681/ASN.2007010089
   Kurella M, 2005, J AM SOC NEPHROL, V16, P2134, DOI 10.1681/ASN.2005010106
   Lander HM, 1997, J BIOL CHEM, V272, P17810, DOI 10.1074/jbc.272.28.17810
   Levey AS, 2009, ANN INTERN MED, V150, P604, DOI 10.7326/0003-4819-150-9-200905050-00006
   Liu YH, 2011, CYTOKINE, V55, P229, DOI 10.1016/j.cyto.2011.05.003
   Menini S, 2004, J HYPERTENS, V22, P2185, DOI 10.1097/00004872-200411000-00022
   Nguyen MTA, 2007, J BIOL CHEM, V282, P35279, DOI 10.1074/jbc.M706762200
   Penno G, 2013, J INTERN MED, V274, P176, DOI 10.1111/joim.12073
   Qu Y, 2007, J IMMUNOL, V179, P1913, DOI 10.4049/jimmunol.179.3.1913
   Schroder K, 2010, CELL, V140, P821, DOI 10.1016/j.cell.2010.01.040
   Solini A, 2005, KIDNEY INT, V67, P875, DOI 10.1111/j.1523-1755.2005.00152.x
   Solini A, 2007, AM J PHYSIOL-RENAL, V292, pF1537, DOI 10.1152/ajprenal.00440.2006
   Stienstra R, 2011, P NATL ACAD SCI USA, V108, P15324, DOI 10.1073/pnas.1100255108
   Stienstra R, 2010, CELL METAB, V12, P593, DOI 10.1016/j.cmet.2010.11.011
   Strowig T, 2012, NATURE, V481, P278, DOI 10.1038/nature10759
   Sun LJ, 2002, J BIOL CHEM, V277, P18919, DOI 10.1074/jbc.M110650200
   Sun SY, 2012, DIABETES, V61, P1471, DOI 10.2337/db11-1389
   Taylor SRJ, 2009, J AM SOC NEPHROL, V20, P1275, DOI 10.1681/ASN.2008060559
   Tervaert TWC, 2010, J AM SOC NEPHROL, V21, P556, DOI 10.1681/ASN.2010010010
   Ting JPY, 2008, IMMUNITY, V28, P285, DOI 10.1016/j.immuni.2008.02.005
   Vandanmagsar B, 2011, NAT MED, V17, P179, DOI 10.1038/nm.2279
   Vilaysane A, 2010, J AM SOC NEPHROL, V21, P1732, DOI 10.1681/ASN.2010020143
   Vonend O, 2004, KIDNEY INT, V66, P157, DOI 10.1111/j.1523-1755.2004.00717.x
   Ward JR, 2010, J BIOL CHEM, V285, P23145, DOI 10.1074/jbc.M109.072793
   Wen HT, 2012, NAT IMMUNOL, V13, P352, DOI 10.1038/ni.2228
   Wen HT, 2011, NAT IMMUNOL, V12, P408, DOI 10.1038/ni.2022
   Yazdi AS, 2010, J INNATE IMMUN, V2, P228, DOI 10.1159/000283688
NR 51
TC 106
Z9 113
U1 0
U2 24
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3417
EI 1096-9896
J9 J PATHOL
JI J. Pathol.
PD NOV
PY 2013
VL 231
IS 3
BP 342
EP 353
DI 10.1002/path.4237
PG 12
WC Oncology; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Pathology
GA 232FG
UT WOS:000325476500007
PM 23843215
DA 2025-06-11
ER

PT J
AU Molokwu, JC
   Penaranda, E
   Lopez, DS
   Dwivedi, A
   Dodoo, C
   Shokar, N
AF Molokwu, Jennifer C.
   Penaranda, Eribeth
   Lopez, David S.
   Dwivedi, Alok
   Dodoo, Christopher
   Shokar, Navkiran
TI Association of Metabolic Syndrome and Human Papillomavirus Infection in
   Men and Women Residing in the United States
SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
LA English
DT Article
ID RISK-FACTORS; CERVICAL-CANCER; PREVALENCE; COMPONENTS; CYTOKINES; HPV
AB Background: An estimated 33% of adults in the United States have metabolic syndrome (MetS), which has been associated with an increased risk for various cancer types. Theories of synergism among components of MetS that increase cancer risk via chronic inflammation and oxidative stress have been proposed. We hypothesize that men and women with MetS may have compromised immunological response resulting in increased risk for persistent human papillomavirus (HPV) infection. The goal of this study is to determine the association of MetS with HPV types 6, 11, 16, and 18 and to explore variation of these associations by gender using data from a national survey.
   Methods: We conducted a retrospective cross-sectional study using data from the National Health and Nutrition Examination Survey.
   Results: Thirty-two percent of the population sampled met the criteria for MetS (16% men and 33% women). Nineteen percent tested positive for HPV (6, 11, 16, and 18). Prevalence of HPV infection was estimated at 13% for men and 30% for females. MetS was found to be significantly associated with increased risk of HPV6, 11, 16, or 18 in the entire cohort [RR = 1.24; 95% confidence interval (CI), 1.03-1.48] and in females (RR = 1.26; 95% CI, 1.02-1.56). Although the adjusted risk of HPV+ve status was found to be 21% higher in men with MetS compared with those without, this difference did not attain statistical significance.
   Conclusions: We observed a significant association between metabolic syndrome and HPV sero-positivity among the overall population and among females. Although not significant, a similar effect was noted in men. Further prospective studies are needed to better understand this relationship.
   Impact: To the best of our knowledge, this is the first study evaluating the impact of metabolic syndrome on HPV positivity in both males and females. (C) 2017 AACR.
C1 [Molokwu, Jennifer C.; Penaranda, Eribeth; Shokar, Navkiran] Texas Tech Univ, Hlth Sci Ctr El Paso, Dept Family & Community Med, 9849 Kenworthy St, El Paso, TX 79924 USA.
   [Lopez, David S.] Univ Texas Houston, Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Houston, TX USA.
   [Dwivedi, Alok; Dodoo, Christopher] Texas Tech Univ, Hlth Sci Ctr El Paso, Grad Sch Biomed Sci, Dept Biostat & Epidemiol, 9849 Kenworthy St, El Paso, TX 79924 USA.
C3 Texas Tech University System; Texas Tech University; Texas Tech
   University Health Sciences Center El Paso; University of Texas System;
   University of Texas Health Science Center Houston; University of Texas
   School Public Health; Texas Tech University System; Texas Tech
   University; Texas Tech University Health Sciences Center El Paso
RP Molokwu, JC (corresponding author), Texas Tech Univ, Hlth Sci Ctr El Paso, 9849 Kenworthy St, El Paso, TX 79924 USA.
EM jennifer.molokwu@ttuhsc.edu
RI Dodoo, Christpher/AAE-9313-2019; Molokwu, Jennifer/J-1317-2019
OI Molokwu, Jennifer/0000-0001-7846-8189; Shokar,
   Navkiran/0000-0002-8514-9132; Lopez, David S./0000-0002-2321-0372;
   Dodoo, Christopher/0000-0001-6269-1757
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Ahn HK, 2015, TUMOR BIOL, V36, P2201, DOI 10.1007/s13277-014-2831-y
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   [Anonymous], 2007, NAT HLTH NUTR EX SUR
   [Anonymous], 2005, National Health and Nutrition Examination Survey data
   [Anonymous], 2010, NCHS RES ETH REV BOA
   [Anonymous], 2009, National Health and Nutrition Examination Survey
   Baker R, 2011, CYTOKINE, V53, P282, DOI 10.1016/j.cyto.2010.11.014
   Bárdos JI, 2005, BBA-REV CANCER, V1755, P107, DOI 10.1016/j.bbcan.2005.05.001
   Bernard HU, 2010, VIROLOGY, V401, P70, DOI 10.1016/j.virol.2010.02.002
   Bodily J, 2011, TRENDS MICROBIOL, V19, P33, DOI 10.1016/j.tim.2010.10.002
   Borena W, 2012, INT J CANCER, V131, P193, DOI 10.1002/ijc.26338
   Bosch FX, 2002, J CLIN PATHOL, V55, P244, DOI 10.1136/jcp.55.4.244
   BRINTON LA, 1987, JNCI-J NATL CANCER I, V79, P23
   Cowey S, 2006, AM J PATHOL, V169, P1505, DOI 10.2353/ajpath.2006.051090
   Cuzick J, 2003, LANCET, V362, P1871, DOI 10.1016/S0140-6736(03)14955-0
   Dwivedi AK, 2014, J APPL STAT, V41, P484, DOI 10.1080/02664763.2013.840772
   HUANG X, 2016, MEDICINE, V95
   Johansen D, 2010, CANCER EPIDEM BIOMAR, V19, P2307, DOI 10.1158/1055-9965.EPI-10-0234
   Johnson C.L., 2014, National health and nutrition examination survey: sample design, 2011-2014 No
   Kemp TJ, 2010, CANCER EPIDEM BIOMAR, V19, P1954, DOI 10.1158/1055-9965.EPI-10-0184
   Laukkanen JA, 2004, CANCER EPIDEM BIOMAR, V13, P1646
   Li N, 2011, INT J CANCER, V128, P927, DOI 10.1002/ijc.25396
   Liu Su-Hsun, 2015, BMC Obes, V2, P39, DOI 10.1186/s40608-015-0071-3
   Molano M, 2003, AM J EPIDEMIOL, V158, P486, DOI 10.1093/aje/kwg171
   Parkin DM, 2006, VACCINE, V24, P11, DOI 10.1016/j.vaccine.2006.05.111
   Partridge JM, 2006, LANCET INFECT DIS, V6, P21, DOI 10.1016/S1473-3099(05)70323-6
   Penaranda Eribeth K, 2013, ISRN Oncol, V2013, P840964, DOI 10.1155/2013/840964
   Rajkumar T, 2006, INT J CANCER, V118, P1481
   Richardson H, 2003, CANCER EPIDEM BIOMAR, V12, P485
   Satterwhite CL, 2013, SEX TRANSM DIS, V40, P187, DOI 10.1097/OLQ.0b013e318286bb53
   Scott M, 2001, CLIN DIAGN LAB IMMUN, V8, P209, DOI 10.1128/CDLI.8.2.209-220.2001
   Smith JS, 2003, LANCET, V361, P1159, DOI 10.1016/S0140-6736(03)12949-2
   Stocks T, 2008, INT J OBESITY, V32, P304, DOI 10.1038/sj.ijo.0803713
   Stone KM, 2002, J INFECT DIS, V186, P1396, DOI 10.1086/344354
   Trottier H, 2009, PUBLIC HEALTH GENOM, V12, P291, DOI 10.1159/000214920
   Ulmer H, 2012, GYNECOL ONCOL, V125, P330, DOI 10.1016/j.ygyno.2012.01.052
   Ursin G, 1996, CANCER CAUSE CONTROL, V7, P391, DOI 10.1007/BF00052946
   Wee CC, 2008, OBESITY, V16, P2552, DOI 10.1038/oby.2008.394
   Wisse BE, 2004, J AM SOC NEPHROL, V15, P2792, DOI 10.1097/01.ASN.0000141966.69934.21
   Zhou JR, 2007, AM J CLIN NUTR, V86, p817S, DOI 10.1093/ajcn/86.3.817S
NR 41
TC 18
Z9 18
U1 0
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1055-9965
EI 1538-7755
J9 CANCER EPIDEM BIOMAR
JI Cancer Epidemiol. Biomarkers Prev.
PD AUG
PY 2017
VL 26
IS 8
BP 1321
EP 1327
DI 10.1158/1055-9965.EPI-17-0129
PG 7
WC Oncology; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Public, Environmental & Occupational Health
GA FI8BY
UT WOS:000412226500019
PM 28483969
DA 2025-06-11
ER

PT J
AU Wu, KLH
   Hung, CY
   Chan, JYH
   Wu, CW
AF Wu, Kay L. H.
   Hung, Chun-Ying
   Chan, Julie Y. H.
   Wu, Chih-Wei
TI An increase in adenosine-5′-triphosphate (ATP) content in rostral
   ventrolateral medulla is engaged in the high fructose diet-induced
   hypertension
SO JOURNAL OF BIOMEDICAL SCIENCE
LA English
DT Article
DE Adenosine-5 '-triphosphate; Metabolic syndrome; Fructose; Fructolysis;
   Glucose transporter; Ketohexokinase; Rostral ventrolateral medulla;
   Hypertension
ID INDUCED METABOLIC SYNDROME; SYMPATHETIC-NERVE ACTIVITY; OXIDATIVE
   STRESS; SWEETENED BEVERAGES; ARTERIAL-PRESSURE; SUPEROXIDE ANION; P2
   RECEPTORS; GLUCOSE; OBESITY; RATS
AB Background: The increase in fructose ingestion has been linked to overdrive of sympathetic activity and hypertension associated with the metabolic syndrome. The premotor neurons for generation of sympathetic vasomotor activity reside in the rostral ventrolateral medulla (RVLM). Activation of RVLM results in sympathoexcitation and hypertension. Neurons in the central nervous system are able to utilize fructose as a carbon source of ATP production. We examined in this study whether fructose affects ATP content in RVLM and its significance in the increase in central sympathetic outflow and hypertension induced by the high fructose diet (HFD).
   Results: In normotensive rats fed with high fructose diet (HFD) for 12 weeks, there was a significant increase in tissue ATP content in RVLM, accompanied by the increases in the sympathetic vasomotor activity and blood pressure. These changes were blunted by intracisternal infusion of an ATP synthase inhibitor, oligomycin, to the HFD-fed animals. In the catecholaminergic-containing N2a cells, fructose dose-dependently upregulated the expressions of glucose transporter 2 and 5 (GluT2, 5) and the rate-limiting enzyme of fructolysis, ketohexokinase (KHK), leading to the increases in pyruvate and ATP production, as well as the release of the neurotransmitter, dopamine. These cellular events were significantly prevented after the gene knocking down by lentiviral transfection of small hairpin RNA against KHK.
   Conclusion: These results suggest that increases in ATP content in RVLM may be engaged in the augmented sympathetic vasomotor activity and hypertension associated with the metabolic syndrome induced by the HFD. At cellular level, the increase in pyruvate levels via fructolysis is involved in the fructose-induced ATP production and the release of neurotransmitter.
C1 [Wu, Kay L. H.; Hung, Chun-Ying; Chan, Julie Y. H.; Wu, Chih-Wei] Chang Gung Mem Hosp, Ctr Translat Res Biomed Sci, Kaohsiung Med Ctr, Kaohsiung 83301, Taiwan.
C3 Chang Gung Memorial Hospital
RP Wu, KLH (corresponding author), Chang Gung Mem Hosp, Ctr Translat Res Biomed Sci, Kaohsiung Med Ctr, Kaohsiung 83301, Taiwan.
EM klhwu@adm.cgmh.org.tw
RI Wu, Kay/ACD-1767-2022; Chan, Julie/X-5253-2019
OI Wu, Kay L.H./0000-0002-7297-6788
FU Chang Gung Memorial Hospital and National Science Council, Taiwan,
   Republic of China [CMRPG8A0801, CMRPG8B0581, NSC 102-2320-B-182A-008]
FX This study was supported in part by research grants CMRPG8A0801,
   CMRPG8B0581, and NSC 102-2320-B-182A-008 to KLHW from the Chang Gung
   Memorial Hospital and National Science Council, Taiwan, Republic of
   China.
CR Altuncu ME, 2012, CARDIOL J, V19, P501, DOI 10.5603/CJ.2012.0091
   Barone S, 2009, J BIOL CHEM, V284, P5056, DOI 10.1074/jbc.M808128200
   Ben Achour S, 2012, NEUROCHEM RES, V37, P2464, DOI 10.1007/s11064-012-0807-0
   Cassaglia PA, 2011, J PHYSIOL-LONDON, V589, P1643, DOI 10.1113/jphysiol.2011.205575
   Cha SH, 2008, P NATL ACAD SCI USA, V105, P16871, DOI 10.1073/pnas.0809255105
   Chan SHH, 2010, CIRC RES, V107, P1127, DOI 10.1161/CIRCRESAHA.110.225573
   Chan SHH, 2009, CIRC RES, V105, P886, DOI 10.1161/CIRCRESAHA.109.199018
   Chan SHH, 2005, CIRC RES, V97, P772, DOI 10.1161/01.RES.0000185804.79157.C0
   Colombari E, 2001, HYPERTENSION, V38, P549, DOI 10.1161/01.HYP.38.3.549
   Cox CL, 2011, J CLIN ENDOCR METAB, V96, pE2034, DOI 10.1210/jc.2011-1050
   Daneman R, 2010, NATURE, V468, P562, DOI 10.1038/nature09513
   de Moura RF, 2009, BRIT J NUTR, V101, P1178, DOI 10.1017/S0007114508066774
   Dekker MJ, 2010, AM J PHYSIOL-ENDOC M, V299, pE685, DOI 10.1152/ajpendo.00283.2010
   Farah V, 2006, AUTON NEUROSCI-BASIC, V130, P41, DOI 10.1016/j.autneu.2006.05.006
   Fried SK, 2003, AM J CLIN NUTR, V78, p873S, DOI 10.1093/ajcn/78.4.873S
   Funari VA, 2005, MOL BRAIN RES, V142, P115, DOI 10.1016/j.molbrainres.2005.09.019
   Hayward LF, 2012, AUTON NEUROSCI-BASIC, V171, P58, DOI 10.1016/j.autneu.2012.10.008
   Huang FY, 2010, CLIN EXP HYPERTENS, V32, P98, DOI 10.3109/10641960902993129
   Ishimoto T, 2012, P NATL ACAD SCI USA, V109, P4320, DOI 10.1073/pnas.1119908109
   Ito S, 2000, HYPERTENSION, V35, P413, DOI 10.1161/01.HYP.35.1.413
   Izumi Y, 2009, NEUROSCIENCE, V161, P847, DOI 10.1016/j.neuroscience.2009.04.008
   Izumi Y, 1997, NEUROSCI LETT, V232, P17, DOI 10.1016/S0304-3940(97)00567-3
   Johnson RJ, 2007, AM J CLIN NUTR, V86, P899
   Keating DJ, 2008, J NEUROCHEM, V104, P298, DOI 10.1111/j.1471-4159.2007.04997.x
   Kellett GL, 2008, ANNU REV NUTR, V28, P35, DOI 10.1146/annurev.nutr.28.061807.155518
   Kellett GL, 2005, DIABETES, V54, P3056, DOI 10.2337/diabetes.54.10.3056
   Khitan Z, 2013, J NUTR METAB, V2013, DOI 10.1155/2013/682673
   Kishi T, 2011, CLIN EXP HYPERTENS, V33, P240, DOI 10.3109/10641963.2011.583969
   Malik VS, 2006, AM J CLIN NUTR, V84, P274
   Mancia G, 2007, J HYPERTENS, V25, P909, DOI 10.1097/HJH.0b013e328048d004
   Mayer MA, 2008, REGUL PEPTIDES, V146, P38, DOI 10.1016/j.regpep.2007.07.006
   Mochida S, 2011, NEUROSCI RES, V70, P16, DOI 10.1016/j.neures.2011.03.005
   Moraes-Silva IC, 2010, CLIN EXP PHARMACOL P, V37, pe114, DOI 10.1111/j.1440-1681.2009.05333.x
   Nagae A, 2009, CIRCULATION, V119, P978, DOI 10.1161/CIRCULATIONAHA.108.824730
   Oron-Herman M, 2008, AM J HYPERTENS, V21, P1018, DOI 10.1038/ajh.2008.218
   Page KA, 2013, JAMA-J AM MED ASSOC, V309, P63, DOI 10.1001/jama.2012.116975
   Price TO, 2012, ENDOCRINOLOGY, V153, P362, DOI 10.1210/en.2011-1638
   Ralevic V, 1999, NEUROSCIENCE, V94, P867, DOI 10.1016/S0306-4522(99)00376-0
   Ralevic V, 2000, J AUTONOM NERV SYST, V81, P205, DOI 10.1016/S0165-1838(00)00139-9
   ROSS CA, 1984, J COMP NEUROL, V228, P168, DOI 10.1002/cne.902280204
   Sanchez-Lozada LG, 2007, AM J PHYSIOL-RENAL, V292, pF423, DOI 10.1152/ajprenal.00124.2006
   Schreihofer AM, 2000, J PHYSIOL-LONDON, V529, P221, DOI 10.1111/j.1469-7793.2000.00221.x
   Sharabi Y, 2007, AM J HYPERTENS, V20, P206, DOI 10.1016/j.amjhyper.2006.08.002
   Singh PP, 2009, INDIAN J CLIN BIOCHE, V24, P324, DOI 10.1007/s12291-009-0062-6
   SUN MK, 1992, EUR J PHARMACOL, V224, P93, DOI 10.1016/0014-2999(92)94824-F
   Tai MH, 2005, FREE RADICAL BIO MED, V38, P450, DOI 10.1016/j.freeradbiomed.2004.11.015
   Tappy L, 2010, NUTRITION, V26, P1044, DOI 10.1016/j.nut.2010.02.014
   Tappy L, 2010, PHYSIOL REV, V90, P23, DOI 10.1152/physrev.00019.2009
   Tentolouris N, 2008, NEUROMOL MED, V10, P169, DOI 10.1007/s12017-008-8022-5
   Tremblay RG, 2010, J NEUROSCI METH, V186, P60, DOI 10.1016/j.jneumeth.2009.11.004
   Wu KLH, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-212
   Yokozawa T, 2008, J AGR FOOD CHEM, V56, P5026, DOI 10.1021/jf800213f
   Zamami Y, 2011, HYPERTENS RES, V34, P1190, DOI 10.1038/hr.2011.97
   Zhao FQ, 2007, CURR GENOMICS, V8, P113, DOI 10.2174/138920207780368187
   ZIMMERMANN H, 1993, J PHYSIOLOGY-PARIS, V87, P159, DOI 10.1016/0928-4257(93)90027-Q
NR 55
TC 20
Z9 25
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1021-7770
EI 1423-0127
J9 J BIOMED SCI
JI J. Biomed. Sci.
PD JAN 27
PY 2014
VL 21
AR 8
DI 10.1186/1423-0127-21-8
PG 14
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA AF3VS
UT WOS:000334641100001
PM 24467657
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ferrer, MD
   Reynes, C
   Jiménez, L
   Malagraba, G
   Monserrat-Mesquida, M
   Bouzas, C
   Sureda, A
   Tur, JA
   Pons, A
AF Ferrer, Miguel D.
   Reynes, Clara
   Jimenez, Laura
   Malagraba, Gianluca
   Monserrat-Mesquida, Margalida
   Bouzas, Cristina
   Sureda, Antoni
   Tur, Josep A.
   Pons, Antoni
TI Nitrite Attenuates the In Vitro Inflammatory Response of Immune Cells to
   the SARS-CoV-2 S Protein without Interfering in the Antioxidant Enzyme
   Activation
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE antioxidants; COVID-19; inflammation; nitric oxide; nitrite; SARS-CoV-2
ID DOUBLE-STRANDED-RNA; NF-KAPPA-B; OXIDATIVE STRESS; RECOGNITION; NITRATE;
   SUPPLEMENTATION; MACROPHAGES; DYSFUNCTION; GENERATION; EXERCISE
AB SARS-CoV-2 induces a hyperinflammatory reaction due to the excessive release of cytokines during the immune response. The bacterial endotoxin lipopolysaccharide (LPS) contributes to the low-grade inflammation associated with the metabolic syndrome, enhancing the hyperinflammatory reaction induced by the SARS-CoV-2 infection. The intake of sodium nitrate, a precursor of nitrite and nitric oxide, influences the antioxidant and pro-inflammatory gene expression profile after immune stimulation with LPS in peripheral blood mononuclear cells from metabolic syndrome patients. We aimed to assess the inflammatory and antioxidant responses of immune cells from metabolic syndrome patients to exposure to the SARS-CoV-2 spike protein (S protein) together with LPS and the effect of nitrite in these responses. Whole blood samples obtained from six metabolic syndrome patients were cultured for 16 h at 37 degrees C with four different media: control medium, control medium plus LPS (100 ng/mL), control medium plus LPS (100 ng/mL) plus S protein (10 ng/mL), and control medium plus LPS (100 ng/mL) plus S protein (10 ng/mL) plus nitrite (5 mu M). Immune stimulation with the LPS/S protein enhanced nitrate biosynthesis from nitrite oxidation and probably from additional organic precursors. In vitro incubations with the LPS/S protein enhanced the expression and/or release of pro-inflammatory TNF alpha, IL-6, IL-1 beta, and TLR4, as well as the expression of the anti-inflammatory IL-1ra and IL-10 and antioxidant enzymes. Nitrite attenuated the pro- and anti-inflammatory response induced by the S protein without interfering with the activation of TLR4 and antioxidant enzyme expression, raising the possibility that nitrite could have potential as a coadjutant in the treatment of COVID-19.
C1 [Ferrer, Miguel D.; Reynes, Clara; Jimenez, Laura; Malagraba, Gianluca; Monserrat-Mesquida, Margalida; Bouzas, Cristina; Sureda, Antoni; Tur, Josep A.; Pons, Antoni] Univ Balear Isl, Res Grp Community Nutr & Oxidat Stress, IUNICS, Palma De Mallorca 07122, Spain.
   [Ferrer, Miguel D.; Monserrat-Mesquida, Margalida; Bouzas, Cristina; Sureda, Antoni; Tur, Josep A.; Pons, Antoni] Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca 07120, Spain.
   [Monserrat-Mesquida, Margalida; Bouzas, Cristina; Sureda, Antoni; Tur, Josep A.; Pons, Antoni] Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBER, Madrid 28029, Spain.
C3 Universitat de les Illes Balears; IUNICS; Institut Investigacio
   Sanitaria Illes Balears (IdISBa)
RP Ferrer, MD; Pons, A (corresponding author), Univ Balear Isl, Res Grp Community Nutr & Oxidat Stress, IUNICS, Palma De Mallorca 07122, Spain.; Ferrer, MD; Pons, A (corresponding author), Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca 07120, Spain.; Pons, A (corresponding author), Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBER, Madrid 28029, Spain.
EM miguel-david.ferrer@uib.es; gianluca.malagraba@uib.es;
   margalida.monserrat@uib.es; cristina.bouzas@uib.es;
   antoni.sureda@uib.es; pep.tur@uib.es; antonipons@uib.es
RI Tur, Josep/AAE-5748-2020; Sureda, Antoni/N-9588-2019; Mesquida,
   Margalida/AAB-4773-2019; Bouzas, Cristina/AAE-2069-2019; Jiménez,
   Laura/G-9885-2016; Reynés, Miguel/J-4206-2019; Pons, Antoni/L-4844-2014;
   Tur, Josep/F-5576-2014
OI Bouzas Velasco, Cristina/0000-0002-1407-8461; Monserrat Mesquida,
   Margalida/0000-0002-8856-135X; Pons, Antoni/0000-0003-2447-3868; Tur,
   Josep/0000-0002-6940-0761; Ferrer, Miguel D./0000-0003-1924-7727; ,
   Antoni/0000-0001-8656-6838
FU Instituto de Salud Carlos III through the Fondo de Investigacin para la
   Salud
FX No Statement Available
CR Alamdari DH, 2020, EUR J PHARMACOL, V885, DOI 10.1016/j.ejphar.2020.173494
   Alexopoulou L, 2001, NATURE, V413, P732, DOI 10.1038/35099560
   Arulselvan P, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/5276130
   Assar S, 2023, MOL BIOL REP, V50, P9925, DOI 10.1007/s11033-023-08835-1
   Badawy MA, 2021, ELIFE, V10, DOI [10.7554/eLife.69417, 10.7554/eLife.69417.sa0, 10.7554/eLife.69417.sa1, 10.7554/eLife.69417.sa2]
   Bansal R, 2020, ENDOCRINOLOGY, V161, DOI 10.1210/endocr/bqaa112
   Cani PD, 2009, CURR OPIN PHARMACOL, V9, P737, DOI 10.1016/j.coph.2009.06.016
   Capó X, 2014, CYTOKINE, V69, P155, DOI 10.1016/j.cyto.2014.05.026
   Capó X, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9070596
   Castro AM., 2017, Revista Medica del Hospital General de Mexico, V80, P101, DOI [10.1016/j.hgmx.2016.06, DOI 10.1016/J.HGMX.2016.06]
   Chaikijurajai T, 2020, EXPERT OPIN THER TAR, V24, P695, DOI 10.1080/14728222.2020.1762177
   Ciesielska A, 2021, CELL MOL LIFE SCI, V78, P1233, DOI 10.1007/s00018-020-03656-y
   de Sousa Joao Antonio Costa, 2023, Oxid Med Cell Longev, V2023, P4752502, DOI 10.1155/2023/4752502
   Dejam A, 2007, CIRCULATION, V116, P1821, DOI 10.1161/CIRCULATIONAHA.107.712133
   Deon D, 2001, J IMMUNOL, V167, P5395, DOI 10.4049/jimmunol.167.9.5395
   Diebold SS, 2004, SCIENCE, V303, P1529, DOI 10.1126/science.1093616
   Dominic P, 2021, REDOX BIOL, V43, DOI 10.1016/j.redox.2021.101982
   Fang H, 2023, MEDIAT INFLAMM, V2023, DOI 10.1155/2023/5133505
   Fara A, 2020, OPEN BIOL, V10, DOI 10.1098/rsob.200160
   Ferrer MD, 2021, J CLIN MED, V10, DOI 10.3390/jcm10122618
   Ferrer MD, 2010, CELL PHYSIOL BIOCHEM, V25, P241, DOI 10.1159/000276558
   Frydrych L, 2018, J LEUKOCYTE BIOL, V104, P525, DOI 10.1002/JLB.5VMR0118-021RR
   Hayman TJ, 2019, IMMUNOL CELL BIOL, V97, P840, DOI 10.1111/imcb.12284
   Hsu AC-Y, 2020, SARS COV 2 SPIKE PRO, DOI [DOI 10.1101/2020.09.30.317818, 10.1101/2020.09.30.317818v1]
   Hu BY, 2021, J MED VIROL, V93, P250, DOI 10.1002/jmv.26232
   Hunault CC, 2009, TOXICOL LETT, V190, P48, DOI 10.1016/j.toxlet.2009.06.865
   Kapil V, 2020, PHARMACOL REV, V72, P692, DOI 10.1124/pr.120.019240
   Kawai T, 2007, TRENDS MOL MED, V13, P460, DOI 10.1016/j.molmed.2007.09.002
   Korakas E, 2020, AM J PHYSIOL-ENDOC M, V319, pE105, DOI 10.1152/ajpendo.00198.2020
   Kruglikov IL, 2021, PLOS PATHOG, V17, DOI 10.1371/journal.ppat.1009306
   Kwon J, 2022, CELL MOL NEUROBIOL, V42, P2655, DOI 10.1007/s10571-021-01127-x
   Le Goffic R, 2007, J IMMUNOL, V178, P3368, DOI 10.4049/jimmunol.178.6.3368
   Li XM, 2021, EXP THER MED, V21, DOI 10.3892/etm.2020.9435
   Lorente L, 2022, MED INTENSIVA, V46, P132, DOI 10.1016/j.medine.2020.10.007
   Lundberg JO, 2008, NAT REV DRUG DISCOV, V7, DOI [10.1038/nrd2466-c2, 10.1038/nrd2466]
   Lundberg JO, 2011, CARDIOVASC RES, V89, P525, DOI 10.1093/cvr/cvq325
   Majumder N, 2022, REDOX BIOL, V56, DOI 10.1016/j.redox.2022.102465
   Minihane AM, 2015, BRIT J NUTR, V114, P999, DOI 10.1017/S0007114515002093
   Monserrat-Mesquida M, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9030236
   Pedersen BK, 2007, J APPL PHYSIOL, V103, P1093, DOI 10.1152/japplphysiol.00080.2007
   Peleli M, 2020, REDOX BIOL, V28, DOI 10.1016/j.redox.2019.101387
   Petrilli Christopher M., 2020, The BMJ, V369, DOI 10.1136/bmj.m1966
   Petruk G, 2020, J MOL CELL BIOL, V12, P916, DOI 10.1093/jmcb/mjaa067
   Ruan QR, 2020, INTENS CARE MED, V46, P846, DOI 10.1007/s00134-020-05991-x
   Saito T, 2008, J EXP MED, V205, P1523, DOI 10.1084/jem.20081210
   Schiffer TA, 2020, BBA-MOL BASIS DIS, V1866, DOI 10.1016/j.bbadis.2020.165811
   SCHINDLER R, 1990, BLOOD, V75, P40
   Shakoory B, 2016, CRIT CARE MED, V44, P275, DOI 10.1097/CCM.0000000000001402
   Somensi N, 2019, INT IMMUNOPHARMACOL, V75, DOI 10.1016/j.intimp.2019.105743
   Sureda A, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010146
   Sureda A, 2014, PHYSIOL GENOMICS, V46, P647, DOI 10.1152/physiolgenomics.00028.2014
   Tian R, 2020, NITRIC OXIDE-BIOL CH, V96, P54, DOI 10.1016/j.niox.2020.01.007
   Wang F, 2020, J INFECT DIS, V221, P1762, DOI 10.1093/infdis/jiaa150
   WHO, A healthy lifestyle-WHO recommendations
   Xu XL, 2020, P NATL ACAD SCI USA, V117, P10970, DOI 10.1073/pnas.2005615117
   Yang T, 2015, FREE RADICAL BIO MED, V83, P159, DOI 10.1016/j.freeradbiomed.2015.02.016
   Zhou Y, 2021, DIABETES-METAB RES, V37, DOI 10.1002/dmrr.3377
NR 57
TC 0
Z9 0
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2024
VL 25
IS 5
AR 3001
DI 10.3390/ijms25053001
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA KV6U3
UT WOS:001182785200001
PM 38474248
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Skop, V
   Malínská, H
   Trnovská, J
   Hüttl, M
   Cahová, M
   Blachnio-Zabielska, A
   Baranowski, M
   Burian, M
   Oliyarnyk, O
   Kazdová, L
AF Skop, Vojtech
   Malinska, Hana
   Trnovska, Jaroslava
   Huettl, Martina
   Cahova, Monika
   Blachnio-Zabielska, Agnieszka
   Baranowski, Marcin
   Burian, Martin
   Oliyarnyk, Olena
   Kazdova, Ludmila
TI Positive Effects of Voluntary Running on Metabolic Syndrome-Related
   Disorders in Non-Obese Hereditary Hypertriacylglycerolemic Rats
SO PLOS ONE
LA English
DT Article
ID BROWN ADIPOSE-TISSUE; FATTY-ACID-COMPOSITION; SOFT DRINK CONSUMPTION;
   INSULIN-RESISTANCE; SKELETAL-MUSCLE; EXPERIMENTAL-MODEL; OXIDATIVE
   STRESS; PHYSICAL-EXERCISE; LIPID-CONTENT; DIACYLGLYCEROL
AB While metabolic syndrome is often associated with obesity, 25% of humans suffering from it are not obese and the effect of physical activity remains unclear in such cases. Therefore, we used hereditary hypertriaclyglycerolemic (HHTg) rats as a unique model for studying the effect of spontaneous physical activity [voluntary running (VR)] on metabolic syndrome-related disorders, such as dyslipidemia, in non-obese subjects. Adult HHTg males were fed standard (CD) or high-sucrose (HSD) diets ad libitum for four weeks. Within both dietary groups, some of the rats had free access to a running wheel (CD+VR, HSD+VR), whereas the controls (CD, HSD) had no possibility of extra physical activity. At the end of the four weeks, we measured the effects of VR on various metabolic syndrome-associated parameters: (i) biochemical parameters, (ii) the content and composition of triacylglycerols (TAG), diacylglycerols (DAG), ceramides and membrane phospholipids, and (iii) substrate utilization in brown adipose tissue. In both dietary groups, VR led to various positive effects: reduced epididymal and perirenal fat depots; increased epididymal adipose tissue lipolysis; decreased amounts of serum TAG, non-esterified fatty acids and insulin; a higher insulin sensitivity index. While tissue ceramide content was not affected, decreased TAG accumulation resulted in reduced and modified liver, heart and skeletal muscle DAG. VR also had a beneficial effect on muscle membrane phospholipid composition. In addition, compared with the CD group, the CD+VR rats exhibited increased fatty acid oxidation and protein content in brown adipose tissue. Our results confirm that physical activity in a non-obese model of severe dyslipidemia has many beneficial effects and can even counteract the negative effects of sucrose consumption. Furthermore, they suggest that the mechanism by which these effects are modulated involves a combination of several positive changes in lipid metabolism.
C1 [Skop, Vojtech; Malinska, Hana; Trnovska, Jaroslava; Huettl, Martina; Cahova, Monika; Burian, Martin; Oliyarnyk, Olena; Kazdova, Ludmila] Inst Clin & Expt Med, Ctr Med Expt, Prague, Czech Republic.
   [Skop, Vojtech] Univ Chem & Technol, Dept Biochem & Microbiol, Prague, Czech Republic.
   [Blachnio-Zabielska, Agnieszka; Baranowski, Marcin] Med Univ Bialystok, Dept Physiol, Bialystok, Poland.
C3 Institute for Clinical & Experimental Medicine (IKEM); University of
   Chemistry & Technology, Prague; Medical University of Bialystok
RP Skop, V (corresponding author), Inst Clin & Expt Med, Ctr Med Expt, Prague, Czech Republic.
EM skov@ikem.cz
RI Cahova, Monika/Z-1568-2018; Oliyarnyk, Olena/Q-6380-2019;
   Blachnio-Zabielsk, Agnieszka/A-4879-2018; Stefanadis,
   Christodoulos/ABH-2232-2020; Skop, Vojtech/LBI-2231-2024; Baranowski,
   Marcin/F-6718-2011
OI Cahova, Monika/0000-0003-2640-5084; Oliyarnyk,
   Olena/0000-0002-4912-6187; Trnovska, Jaroslava/0000-0001-6468-8244;
   Stefanadis, Christodoulos/0000-0001-5974-6454; Blachnio-Zabielska,
   Agnieszka/0000-0002-8055-0576; Skop, Vojtech/0000-0002-4685-4429;
   Baranowski, Marcin/0000-0002-3714-5815
FU Grant Agency of the Czech Republic [P301/11/2418]; MH CZ - DRO
   ("Institute for Clinical and Experimental Medicine - IKEM") [IN 0002301]
FX This work was supported by grant, P301/11/2418, from the Grant Agency of
   the Czech Republic and grant, MH CZ - DRO ("Institute for Clinical and
   Experimental Medicine - IKEM, IN 0002301"). The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
CR Albright A, 2000, MED SCI SPORT EXER, V32, P1345
   Amati F, 2011, DIABETES, V60, P2588, DOI 10.2337/db10-1221
   Andersson A, 1998, AM J PHYSIOL-ENDOC M, V274, pE432, DOI 10.1152/ajpendo.1998.274.3.E432
   Bergman BC, 2012, DIABETOLOGIA, V55, P1140, DOI 10.1007/s00125-011-2419-7
   Bizeau ME, 2005, METABOLISM, V54, P1189, DOI 10.1016/j.metabol.2005.04.004
   Blachnio-Zabielska AU, 2013, J LIPID RES, V54, P1705, DOI 10.1194/jlr.D035006
   Blachnio-Zabielska AU, 2012, RAPID COMMUN MASS SP, V26, P1134, DOI 10.1002/rcm.6216
   Boesch C, 1997, MAGN RESON MED, V37, P484, DOI 10.1002/mrm.1910370403
   BORKMAN M, 1993, NEW ENGL J MED, V328, P238, DOI 10.1056/NEJM199301283280404
   Bray GA, 2004, AM J CLIN NUTR, V79, P537
   Bray GA, 2010, CURR OPIN LIPIDOL, V21, P51, DOI 10.1097/MOL.0b013e3283346ca2
   Chavez JA, 2003, J BIOL CHEM, V278, P10297, DOI 10.1074/jbc.M212307200
   Chen W, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0096056
   Conti FF, 2014, BMC CARDIOVASC DISOR, V14, DOI 10.1186/1471-2261-14-185
   Cypess AM, 2010, CURR OPIN ENDOCRINOL, V17, P143, DOI 10.1097/MED.0b013e328337a81f
   Cypess AM, 2009, NEW ENGL J MED, V360, P1509, DOI 10.1056/NEJMoa0810780
   DAVIES KJA, 1982, BIOCHEM BIOPH RES CO, V107, P1198, DOI 10.1016/S0006-291X(82)80124-1
   Dawn-Linsley M, 2005, J NEUROSCI METH, V141, P219, DOI 10.1016/j.jneumeth.2004.06.010
   De Matteis R, 2013, NUTR METAB CARDIOVAS, V23, P582, DOI 10.1016/j.numecd.2012.01.013
   Deivanayagam S, 2008, AM J CLIN NUTR, V88, P257, DOI 10.1093/ajcn/88.2.257
   Dhingra R, 2007, CIRCULATION, V116, P480, DOI 10.1161/CIRCULATIONAHA.107.689935
   Dubé JJ, 2011, DIABETOLOGIA, V54, P1147, DOI 10.1007/s00125-011-2065-0
   FIELD CJ, 1990, J BIOL CHEM, V265, P11143
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   Galbo T, 2013, AGING-US, V5, P582, DOI 10.18632/aging.100585
   Ghorbani M, 1997, BIOCHEM PHARMACOL, V54, P121, DOI 10.1016/S0006-2952(97)00162-7
   Goodpaster BH, 2001, J CLIN ENDOCR METAB, V86, P5755, DOI 10.1210/jc.86.12.5755
   GRONE EF, 1994, ATHEROSCLEROSIS, V107, P1, DOI 10.1016/0021-9150(94)90136-8
   Guerra C, 1998, J CLIN INVEST, V102, P412, DOI 10.1172/JCI3155
   Hannun YA, 2000, TRENDS CELL BIOL, V10, P73, DOI 10.1016/S0962-8924(99)01694-3
   Helge JW, 1999, J NUTR, V129, P1636, DOI 10.1093/jn/129.9.1636
   Hulver MW, 2004, P NUTR SOC, V63, P375, DOI 10.1079/PNS2004351
   Jacob S, 1999, DIABETES, V48, P1113, DOI 10.2337/diabetes.48.5.1113
   Kahleova H, 2013, NUTR DIABETES, V3, DOI 10.1038/nutd.2013.12
   Katzmarzyk PT, 2003, MED SCI SPORT EXER, V35, P1703, DOI 10.1249/01.MSS.0000089337.73244.9B
   Kazdova L, 1997, ANN NY ACAD SCI, V827, P521, DOI 10.1111/j.1749-6632.1997.tb51863.x
   Ke Z, 2011, IEEE ENG MED BIO, P8223, DOI 10.1109/IEMBS.2011.6092028
   Klimes Iwar, 1995, Blood Pressure, V4, P137, DOI 10.3109/08037059509077585
   Kröger J, 2012, CURR OPIN LIPIDOL, V23, P4, DOI 10.1097/MOL.0b013e32834d2dc5
   Lê KA, 2009, AM J CLIN NUTR, V89, P1760, DOI 10.3945/ajcn.2008.27336
   Li G, 2015, PHYSIOL RES, V64, P355, DOI 10.33549/physiolres.932851
   Li JY, 2014, J NEUROPHYSIOL, V111, P2061, DOI 10.1152/jn.00475.2013
   Longato L, 2012, HEPATOL RES, V42, P412, DOI 10.1111/j.1872-034X.2011.00934.x
   Machann J, 2008, EUR J RADIOL, V67, P275, DOI 10.1016/j.ejrad.2008.02.032
   Marek G, 2015, DIABETES, V64, P508, DOI 10.2337/db14-0411
   Marignani PA, 1996, BIOCHEM BIOPH RES CO, V225, P469, DOI 10.1006/bbrc.1996.1196
   MCALLISTER R A, 1969, Journal of Medical Laboratory Technology, V26, P1
   Najafian Jamshid, 2014, Niger Med J, V55, P29, DOI 10.4103/0300-1652.128156
   Nedergaard J, 2007, AM J PHYSIOL-ENDOC M, V293, pE444, DOI 10.1152/ajpendo.00691.2006
   Nedergaard J, 2010, CELL METAB, V11, P268, DOI 10.1016/j.cmet.2010.03.007
   Parks EJ, 2008, J NUTR, V138, P1039, DOI 10.1093/jn/138.6.1039
   Pelikánová T, 2001, METABOLISM, V50, P1472, DOI 10.1053/meta.2001.27195
   Pravenec M, 2008, INT J OBESITY, V32, P1848, DOI 10.1038/ijo.2008.192
   Pravenec M, 2011, HYPERTENSION, V57, P731, DOI 10.1161/HYPERTENSIONAHA.110.164350
   Radak Z, 2013, ANTIOXID REDOX SIGN, V18, P1208, DOI 10.1089/ars.2011.4498
   Rizkalla SW, 2010, NUTR METAB, V7, DOI 10.1186/1743-7075-7-82
   Saric M, 2012, CURR CARDIOL REP, V14, P342, DOI 10.1007/s11886-012-0261-2
   Sarma S, 2013, CIRC-CARDIOVASC IMAG, V6, P1048, DOI 10.1161/CIRCIMAGING.113.000565
   Segawa M, 1998, RES COMMUN MOL PATH, V100, P77
   Sjögren P, 2008, DIABETOLOGIA, V51, P328, DOI 10.1007/s00125-007-0876-9
   Slocum N, 2013, EXP TOXICOL PATHOL, V65, P549, DOI 10.1016/j.etp.2012.04.001
   Tamura Y, 2008, METABOLISM, V57, P373, DOI 10.1016/j.metabol.2007.10.013
   Tappy L, 2010, PHYSIOL REV, V90, P23, DOI 10.1152/physrev.00019.2009
   Thamer C, 2003, J CLIN ENDOCR METAB, V88, P1785, DOI 10.1210/jc.2002-021674
   Timmers S, 2008, PHYSIOL BEHAV, V94, P242, DOI 10.1016/j.physbeh.2007.12.002
   Trnovská J, 2015, PHYSIOL RES, V64, P51, DOI 10.33549/physiolres.932823
   van Hees AMJ, 2011, OBESITY, V19, P1350, DOI 10.1038/oby.2011.10
   Vessby B, 2002, ANN NY ACAD SCI, V967, P183
   Virtanen KA, 2009, NEW ENGL J MED, V360, P1518, DOI 10.1056/NEJMoa0808949
   Voulgari C, 2011, J AM COLL CARDIOL, V58, P1343, DOI 10.1016/j.jacc.2011.04.047
   VRANA A, 1993, ANN NY ACAD SCI, V683, P57, DOI 10.1111/j.1749-6632.1993.tb35692.x
   VRANA A, 1990, TRANSPLANT P, V22, P2579
   YAMASHITA H, 1993, INT J BIOMETEOROL, V37, P61, DOI 10.1007/BF01212769
   Zicha J, 2006, PHYSIOL RES, V55, pS49, DOI 10.33549/physiolres.930000.55.S1.49
NR 74
TC 8
Z9 9
U1 0
U2 14
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 1
PY 2015
VL 10
IS 4
AR e0122768
DI 10.1371/journal.pone.0122768
PG 19
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CE9AM
UT WOS:000352135600124
PM 25830228
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Vancampfort, D
   Rosenbaum, S
   Probst, M
   Connaughton, J
   du Plessis, C
   Yamamoto, T
   Stubbs, B
AF Vancampfort, Davy
   Rosenbaum, Simon
   Probst, Michel
   Connaughton, Joanne
   du Plessis, Christy
   Yamamoto, Taisei
   Stubbs, Brendon
TI Top 10 research questions to promote physical activity in bipolar
   disorders: A consensus statement from the International Organization of
   Physical Therapists in Mental Health
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Physical activity; Exercise; Mood
ID METABOLIC SYNDROME; EXERCISE; ADULTS; METAANALYSIS; PREVALENCE;
   MORTALITY; DISEASE; ILLNESS; RISK; SCHIZOPHRENIA
AB Background: Research has only recently started to consider the importance and applicability of physical activity (PA) for people with bipolar disorder (BD). The aim of the current study is to highlight 10 pertinent PA research questions in people with BD.
   Methods: The International Organization of Physical Therapy in Mental Health executed a consultation with all National organizations (n=13) to identify the most salient questions to guide future research on PA in BD.
   Results: We identified the following 10 questions: (1) What are the benefits of PA for people with BD? (2) What are the most prominent safety issues for PA prescription in BD? (3) What is the optimal PA prescription for people with BD? (4) What are the key barriers to PA among people with BD? (5) What are the most effective motivational strategies for ensuring PA adoption and maintenance in BD? (6) How do we translate PA research into community practice? (7) If one treatment goal is increased physical activity, what type of professionals are needed as part of a multidisciplinary team? (8) How do we incorporate PA as a vital sign in clinical practice? (9) How can we prevent sedentary behavior in BD? (10) What is the most appropriate PA assessment method?
   Limitations: We did not consult people with BD.
   Conclusions: Addressing these questions is critical for developing evidence-based approaches for promoting and sustaining an active lifestyle in BD. Ultimately, achieving this will reduce the burden of cardiovascular disease and improve the quality of life of this population. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Vancampfort, Davy; Probst, Michel] KU Leuven Univ Leuven, Dept Rehabil Sci, Leuven, Belgium.
   [Vancampfort, Davy] KU Leuven Univ Leuven, Univ Psychiat Ctr, Leuven, Belgium.
   [Rosenbaum, Simon] Univ New S Wales, Sch Psychiat, Sydney, NSW, Australia.
   [Connaughton, Joanne] Univ Notre Dame, Sch Physiotherapy, Fremantle, WA, Australia.
   [du Plessis, Christy] Univ Orange Free State, Bloemfontein, South Africa.
   [Yamamoto, Taisei] Kobe Gakuin Univ, Dept Rehabil Med, Kobe, Hyogo 65121, Japan.
   [Stubbs, Brendon] South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, London, England.
   [Stubbs, Brendon] Kings Coll London, Inst Psychiat, Hlth Serv & Populat Res Dept, London WC2R 2LS, England.
C3 KU Leuven; KU Leuven; University of New South Wales Sydney; The
   University of Notre Dame Australia; University of the Free State; Kobe
   Gakuin University; South London & Maudsley NHS Trust; University of
   London; King's College London
RP Vancampfort, D (corresponding author), KU Leuven Univ Leuven, Univ Psychiat Ctr, Leuvensesteenweg 517, B-3070 Kortenberg, Belgium.
EM davy.vancampfort@uc-kortenberg.be
RI Vancampfort, Davy/AAD-1987-2019; Probst, Michel/ABE-6137-2020; Stubbs,
   Brendon/X-1904-2018; Rosenbaum, Simon/Y-3241-2019; Stubbs,
   Brendon/C-5696-2015
OI Stubbs, Brendon/0000-0001-7387-3791; Rosenbaum,
   Simon/0000-0002-8984-4941
FU Grants-in-Aid for Scientific Research [25300019, 15K01695] Funding
   Source: KAKEN
CR [Anonymous], BR MED J
   Berczik K, 2012, SUBST USE MISUSE, V47, P403, DOI 10.3109/10826084.2011.639120
   Biswas A, 2015, ANN INTERN MED, V162, P123, DOI 10.7326/M14-1651
   Chwastiak L, 2015, J CLIN PSYCHIAT, V76, pE519, DOI 10.4088/JCP.14com09503
   Cooney G., 2014, JAMA-J AM MED ASSOC, V311, P2432
   Courneya KS, 2015, RES Q EXERCISE SPORT, V86, P107, DOI 10.1080/02701367.2015.991265
   Curtis J, 2016, EARLY INTERV PSYCHIA, V10, P267, DOI 10.1111/eip.12230
   DALKEY N, 1963, MANAGE SCI, V9, P458, DOI 10.1287/mnsc.9.3.458
   Dargél AA, 2015, J CLIN PSYCHIAT, V76, P142, DOI 10.4088/JCP.14r09007
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   Deci EL, 2000, PSYCHOL INQ, V11, P227, DOI 10.1207/S15327965PLI1104_01
   Ellingrod VL, 2012, J CLIN PSYCHOPHARM, V32, P261, DOI 10.1097/JCP.0b013e3182485888
   Goldstein BI, 2009, BIPOLAR DISORD, V11, P657, DOI 10.1111/j.1399-5618.2009.00735.x
   Hayes JF, 2015, ACTA PSYCHIAT SCAND, V131, P417, DOI 10.1111/acps.12408
   Hays AE, 2008, MED SCI SPORT EXER, V40, pS17, DOI 10.1249/01.mss.0000321518.49773.7e
   Janney CA, 2014, J AFFECT DISORDERS, V152, P498, DOI 10.1016/j.jad.2013.09.009
   Knapen J, 2015, DISABIL REHABIL, V37, P1490, DOI 10.3109/09638288.2014.972579
   Krogh J, 2011, J CLIN PSYCHIAT, V72, P529, DOI 10.4088/JCP.08r04913blu
   Leaven K., 2012, Mental Health and Physical Activity, V5, P20
   Lesley ML, 2015, J PSYCHOSOC NURS MEN, V53, P46, DOI 10.3928/02793695-20150126-05
   Milton K, 2013, BRIT J SPORT MED, V47, P44, DOI 10.1136/bjsports-2011-090899
   Motl RW, 2015, RES Q EXERCISE SPORT, V86, P117, DOI 10.1080/02701367.2015.1023099
   Ng F, 2007, J AFFECT DISORDERS, V101, P259, DOI 10.1016/j.jad.2006.11.014
   Ng F, 2009, BIPOLAR DISORD, V11, P559, DOI 10.1111/j.1399-5618.2009.00737.x
   Pate RR, 2008, EXERC SPORT SCI REV, V36, P173, DOI 10.1097/JES.0b013e3181877d1a
   Prieto ML, 2014, ACTA PSYCHIAT SCAND, V130, P342, DOI 10.1111/acps.12293
   PROCHASKA JO, 1983, J CONSULT CLIN PSYCH, V51, P390, DOI 10.1037//0022-006X.51.3.390
   Rosenbaum Simon, 2015, Internet Interventions, V2, P214, DOI 10.1016/j.invent.2015.04.001
   Rosenbaum S, 2014, J CLIN PSYCHIAT, V75, P964, DOI 10.4088/JCP.13r08765
   Sallis JE, 2006, ANNU REV PUBL HEALTH, V27, P297, DOI 10.1146/annurev.publhealth.27.021405.102100
   Sallis R, 2011, BRIT J SPORT MED, V45, P473, DOI 10.1136/bjsm.2010.083469
   Soundy A, 2014, ARCH PSYCHIAT NURS, V28, P135, DOI 10.1016/j.apnu.2013.12.002
   Stubbs B, 2015, ACTA PSYCHIAT SCAND, V131, P75, DOI 10.1111/acps.12325
   Stubbs B, 2014, ACTA PSYCHIAT SCAND, V130, P470, DOI 10.1111/acps.12313
   Stubbs B, 2015, GEN HOSP PSYCHIAT, V37, P126, DOI 10.1016/j.genhosppsych.2015.01.004
   Stubbs B, 2014, BRIT J PSYCHIAT, V204, P164, DOI 10.1192/bjp.204.2.164
   Sylvia LG, 2013, INT J BIPOLAR DISORD, V1, DOI 10.1186/2194-7511-1-24
   Szabo A, 2013, NUTRITION AND ENHANCED SPORTS PERFORMANCE: MUSCLE BUILDING, ENDURANCE, AND STRENGTH, P65, DOI 10.1016/B978-0-12-396454-0.00006-0
   Thomson D, 2015, FRONT PSYCHOL, V6, DOI 10.3389/fpsyg.2015.00147
   Uebelacker LA, 2014, J PSYCHIATR PRACT, V20, P345, DOI 10.1097/01.pra.0000454779.59859.f8
   Van Citters AD, 2010, COMMUNITY MENT HLT J, V46, P540, DOI 10.1007/s10597-009-9272-x
   Vancampfort D., 2015, ADOPTING MAINT UNPUB
   Vancampfort D, 2015, PSYCHIAT RES, V228, P100, DOI 10.1016/j.psychres.2015.04.021
   Vancampfort D, 2015, LANCET PSYCHIAT, V2, P295, DOI 10.1016/S2215-0366(15)00099-1
   Vancampfort D, 2015, J AFFECT DISORDERS, V177, P22, DOI 10.1016/j.jad.2014.12.058
   Vancampfort D, 2014, MENT HEALTH PHYS ACT, V7, P153, DOI 10.1016/j.mhpa.2014.11.001
   Vancampfort D, 2013, AM J PSYCHIAT, V170, P265, DOI 10.1176/appi.ajp.2012.12050620
   Vancampfort D, 2013, J AFFECT DISORDERS, V145, P285, DOI 10.1016/j.jad.2012.07.020
   Vancamplort D., 2015, J CLIN PSYC IN PRESS
   Walker ER, 2015, JAMA PSYCHIAT, V72, P334, DOI 10.1001/jamapsychiatry.2014.2502
   Waxmonsky JA, 2005, GEN HOSP PSYCHIAT, V27, P321, DOI 10.1016/j.genhosppsych.2005.05.003
   Zhai L, 2015, BRIT J SPORT MED, V49, P705, DOI 10.1136/bjsports-2014-093613
NR 52
TC 15
Z9 17
U1 0
U2 21
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD MAY
PY 2016
VL 195
BP 82
EP 87
DI 10.1016/j.jad.2016.01.046
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA DF3PP
UT WOS:000371257400010
PM 26874245
DA 2025-06-11
ER

PT J
AU Auvinen, HE
   Romijn, JA
   Biermasz, NR
   Havekes, LM
   Smit, JWA
   Rensen, PCN
   Pereira, AM
AF Auvinen, H. E.
   Romijn, J. A.
   Biermasz, N. R.
   Havekes, L. M.
   Smit, J. W. A.
   Rensen, P. C. N.
   Pereira, A. M.
TI Effects of High Fat Diet on the Basal Activity of the
   Hypothalamus-Pituitary-Adrenal Axis in Mice: A Systematic Review
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Review
DE corticosterone; diet-induced obesity; metabolic syndrome
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; METABOLIC SYNDROME;
   ADIPOSE-TISSUE; GLUCOCORTICOID-RECEPTOR; INSULIN-RESISTANCE; VISCERAL
   OBESITY; STRESS; INHIBITION; EXPRESSION; MORTALITY
AB Hypothalamus-pituitary-adrenal-axis activity is suggested to be involved in the pathophysiology of the metabolic syndrome. In diet-induced obesity mouse models, features of the metabolic syndrome are induced by feeding high fat diet. However, the models reveal conflicting results with respect to the hypothalamus-pituitary-adrenal-axis activation. The aim of this review was to assess the effects of high fat feeding on the activity of the hypothalamus-pituitary-adrenal-axis in mice. PubMed, EMBASE, Web of Science, the Cochrane database, and Science Direct were electronically searched and reviewed by 2 individual researchers. We included only original mouse studies reporting parameters of the hypothalamus-pituitary-adrenal-axis after high fat feeding, and at least 1 basal corticosterone level with a proper control group. Studies with adrenalectomized mice, transgenic animals only, high fat diet for less than 2 weeks, or other interventions besides high fat diet, were excluded. 20 studies were included. The hypothalamus-pituitary-adrenal-axis evaluation was the primary research question in only 5 studies. Plasma corticosterone levels were unchanged in 40%, elevated in 30%, and decreased in 20% of the studies. The effects in the peripheral tissues and the central nervous system were also inconsistent. However, major differences were found between mouse strains, experimental conditions, and the content and duration of the diets. This systematic review demonstrates that the effects of high fat feeding on the basal activity of the hypothalamus-pituitary-adrenal-axis in mice are limited and inconclusive. Differences in experimental conditions hamper comparisons and accentuate the need for standardized evaluations to discern the effects of diet-induced obesity on the hypothalamus-pituitary-adrenal-axis.
C1 [Auvinen, H. E.; Romijn, J. A.; Biermasz, N. R.; Havekes, L. M.; Smit, J. W. A.; Rensen, P. C. N.; Pereira, A. M.] Leiden Univ, Med Ctr, Dept Endocrinol & Metab Dis, NL-2300 RC Leiden, Netherlands.
   [Havekes, L. M.] Gabius Lab, TNO Metab Hlth Res, Leiden, Netherlands.
C3 Leiden University - Excl LUMC; Leiden University; Leiden University
   Medical Center (LUMC); Netherlands Organization Applied Science Research
RP Auvinen, HE (corresponding author), Leiden Univ, Med Ctr, Dept Endocrinol & Metab Dis, Room C5-R61,Albinusdreef 2,POB 9600, NL-2300 RC Leiden, Netherlands.
EM h.e.auvinen@lumc.nl
RI Biermasz, Nienke/ABE-9436-2021; Rensen, Patrick/D-7176-2018; Pereira,
   Alberto M./Q-7175-2017; smit, johannes/H-8091-2014
OI Rensen, Patrick/0000-0002-8455-4988; Pereira, Alberto
   M./0000-0002-1194-9866; smit, johannes/0000-0003-1052-9314
CR AKANA SF, 1994, ENDOCRINOLOGY, V135, P1125, DOI 10.1210/en.135.3.1125
   Alberts P, 2005, HORM METAB RES, V37, P402, DOI 10.1055/s-2005-870228
   Anagnostis P, 2009, J CLIN ENDOCR METAB, V94, P2692, DOI 10.1210/jc.2009-0370
   Bartolomucci A, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004331
   Bullen JW, 2004, AM J PHYSIOL-ENDOC M, V287, pE662, DOI 10.1152/ajpendo.00114.2004
   Chen H, 2007, AM J PHYSIOL-ENDOC M, V293, pE1564, DOI 10.1152/ajpendo.00442.2007
   Cooper MS, 2009, J CLIN ENDOCR METAB, V94, P4645, DOI 10.1210/jc.2009-1412
   Czyzyk TA, 2010, FASEB J, V24, P1151, DOI 10.1096/fj.09-143610
   Dallman MF, 2010, TRENDS ENDOCRIN MET, V21, P159, DOI 10.1016/j.tem.2009.10.004
   de Kloet ER, 2005, NAT REV NEUROSCI, V6, P463, DOI 10.1038/nrn1683
   Dekker JM, 2005, CIRCULATION, V112, P666, DOI 10.1161/CIRCULATIONAHA.104.516948
   Dekkers OM, 2007, J CLIN ENDOCR METAB, V92, P976, DOI 10.1210/jc.2006-2112
   Densmore VS, 2006, ENDOCRINOLOGY, V147, P4486, DOI 10.1210/en.2006-0106
   Di S, 2003, J NEUROSCI, V23, P4850
   Gale EAM, 2005, DIABETOLOGIA, V48, P1679, DOI 10.1007/s00125-005-1873-5
   HERBERG L, 1975, HORM METAB RES, V7, P410, DOI 10.1055/s-0028-1093695
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Kohsaka A, 2007, CELL METAB, V6, P414, DOI 10.1016/j.cmet.2007.09.006
   Liu YJ, 2008, J MOL ENDOCRINOL, V41, P53, DOI 10.1677/JME-08-0004
   Luque RM, 2006, ENDOCRINOLOGY, V147, P2754, DOI 10.1210/en.2005-1549
   Masuzaki H, 2001, SCIENCE, V294, P2166, DOI 10.1126/science.1066285
   Matsumoto S, 2009, MOL ENDOCRINOL, V23, P47, DOI 10.1210/me.2007-0533
   McClean PL, 2007, AM J PHYSIOL-ENDOC M, V293, pE1746, DOI 10.1152/ajpendo.00460.2007
   Michailidou Z, 2008, FASEB J, V22, P3896, DOI 10.1096/fj.08-111914
   Michel C, 2005, HORM BEHAV, V48, P172, DOI 10.1016/j.yhbeh.2005.02.004
   Moraes RC, 2003, ENDOCRINOLOGY, V144, P4773, DOI 10.1210/en.2003-0456
   Morton NM, 2004, DIABETES, V53, P931, DOI 10.2337/diabetes.53.4.931
   Morton NM, 2005, DIABETES, V54, P3371, DOI 10.2337/diabetes.54.12.3371
   Morton NM, 2004, ENDOCRINOLOGY, V145, P2707, DOI 10.1210/en.2003-1674
   Müssig K, 2010, J STEROID BIOCHEM, V121, P589, DOI 10.1016/j.jsbmb.2010.01.008
   Newell-Price J, 2006, LANCET, V367, P1605, DOI 10.1016/S0140-6736(06)68699-6
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   van Dijk G, 2008, EUR J PHARMACOL, V585, P137, DOI 10.1016/j.ejphar.2007.11.079
   Véniant MM, 2009, DIABETES OBES METAB, V11, P109, DOI 10.1111/j.1463-1326.2008.00911.x
   Warne JP, 2009, MOL CELL ENDOCRINOL, V300, P137, DOI 10.1016/j.mce.2008.09.036
   Warrier M, 2010, ENDOCRINOLOGY, V151, P3225, DOI 10.1210/en.2009-1158
   ZIOTOPOULOU M, 2000, AM J PHYSIOL, V279, P838
NR 37
TC 22
Z9 26
U1 0
U2 14
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD DEC
PY 2011
VL 43
IS 13
BP 899
EP 906
DI 10.1055/s-0031-1291305
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 863IG
UT WOS:000298155400001
PM 22068812
DA 2025-06-11
ER

PT J
AU Dogan, A
   Oylumlu, M
AF Dogan, Adnan
   Oylumlu, Muhammed
TI Increased monocyte-to-HDL cholesterol ratio is related to cardiac
   syndrome X
SO ACTA CARDIOLOGICA
LA English
DT Article
DE Cardiac syndrome X; inflammation markers; monocyte-to-HDL cholesterol
   ratio
ID C-REACTIVE PROTEIN; NORMAL CORONARY ARTERIOGRAMS; LEFT-VENTRICULAR
   FUNCTION; INTIMA-MEDIA THICKNESS; SYSTEMIC INFLAMMATION; ENDOTHELIAL
   DYSFUNCTION; ARTERY-DISEASE; PATHOPHYSIOLOGY; ASSOCIATION; PREDICTS
AB Objective: Cardiac syndrome X (CSX) is typically identified with ischaemia in treadmill exercise test or stress myocardial perfusion scintigraphy as well as angina-like chest pain without stenosis in coronary angiography. The purpose of the present study is to investigate the association between cardiac syndrome X and monocyte-to-HDL cholesterol ratio (MHR) which is a new marker associated with inflammation.
   Patients and methods: A total of 230 patients (105 patients with cardiac syndrome X and 125 normal controls) were included in the study. Peripheral venous blood samples were drawn from all study population before coronary angiography for measuring MHR and other haematological parameters.
   Results: The patients with cardiac syndrome X were more likely to have higher platelet counts, plateletcrit (PCT), monocyte count and MHR values. Monocyte count and MHR of the CSX group were significantly higher than the control group [0.53 (0.35-1) vs. 0.49 (0.23-0.96); p = .002, .011 (0.006-0.038) vs. 0.010 (0.004-0.034); p < .001, respectively]. HDL-cholesterol levels of the CSX group were significantly lower than the control groups (46.3 +/- 10.1 vs. 49.6 +/- 11.6; p = .021). Higher MHR and PCT values were found to be associated with the presence of CSX by multivariate logistic regression analysis.
   Conclusions: Elevated MHR level independently was found in association with the presence of CSX. The value of MHR appears additive to conventional expensive methods commonly used in CSX prediction.
C1 [Dogan, Adnan; Oylumlu, Muhammed] Dumlupinar Univ, Dept Cardiol, Sch Med, Kutahya, Turkey.
C3 Dumlupinar University
RP Dogan, A (corresponding author), Dumlupinar Univ, Dept Cardiol, TR-43000 Kutahya, Turkey.
EM doganadnan01@gmail.com
OI Oylumlu, Muhammed/0000-0003-4219-9655
CR Agrawal S, 2014, CARDIOL CLIN, V32, P463, DOI 10.1016/j.ccl.2014.04.006
   Al Suwaidi J, 2001, MAYO CLIN PROC, V76, P813
   Ancuta P, 2006, J LEUKOCYTE BIOL, V80, P1156, DOI 10.1189/jlb.0206125
   Arroyo-Espliguero R, 2003, EUR HEART J, V24, P2006, DOI 10.1016/j.ehj.2003.09.029
   Atmaca Y, 2008, ACTA CARDIOL, V63, P723, DOI 10.2143/AC.63.6.2033389
   Barter PJ, 2004, CIRC RES, V95, P764, DOI 10.1161/01.RES.0000146094.59640.13
   Canpolat U, 2016, CLIN APPL THROMB-HEM, V22, P476, DOI 10.1177/1076029615594002
   Canpolat U, 2015, EUROPACE, V17, P1807, DOI 10.1093/europace/euu291
   Cetin EHO, 2015, BIOMARK MED, V9, P967, DOI 10.2217/bmm.15.74
   Cox ID, 2000, CLIN CARDIOL, V23, P645
   Demirkol S, 2012, CLINICS, V67, P1019, DOI 10.6061/clinics/2012(09)06
   EGASHIRA K, 1993, NEW ENGL J MED, V328, P1659, DOI 10.1056/NEJM199306103282302
   Eroglu S, 2009, ACTA CARDIOL, V64, P207, DOI 10.2143/AC.64.2.2036139
   Ghattas A, 2013, J AM COLL CARDIOL, V62, P1541, DOI 10.1016/j.jacc.2013.07.043
   Hafiane A, 2015, BBA CLIN, V3, P175, DOI 10.1016/j.bbacli.2015.01.005
   Kanbay M, 2014, INT UROL NEPHROL, V46, P1619, DOI 10.1007/s11255-014-0730-1
   KASKI JC, 1995, J AM COLL CARDIOL, V25, P807, DOI 10.1016/0735-1097(94)00507-M
   Kaski JC, 2000, HOSP PRACT, V35, P75, DOI 10.3810/hp.2000.02.183
   KEMP HG, 1973, AM J CARDIOL, V32, P375, DOI 10.1016/S0002-9149(73)80150-X
   Lanza GA, 2004, AM J CARDIOL, V94, P40, DOI 10.1016/j.amjcard.2004.03.027
   Li JJ, 2007, CYTOKINE, V40, P172, DOI 10.1016/j.cyto.2007.09.005
   Lin CP, 2003, INT J CARDIOL, V89, P53, DOI 10.1016/S0167-5273(02)00428-X
   Melikian N, 2008, PROG CARDIOVASC DIS, V50, P294, DOI 10.1016/j.pcad.2007.01.003
   Murphy AJ, 2012, BBA-MOL CELL BIOL L, V1821, P513, DOI 10.1016/j.bbalip.2011.08.003
   Oylumlu M, 2015, POSTEP KARDIOL INTER, V11, P197, DOI 10.5114/pwki.2015.54013
   Panting JR, 2002, NEW ENGL J MED, V346, P1948, DOI 10.1056/NEJMoa012369
   Qing P, 2013, DIS MARKERS, V34, P333, DOI [10.1155/2013/481264, 10.3233/DMA-130977]
   Singh M, 2010, INT J CARDIOL, V142, P113, DOI 10.1016/j.ijcard.2009.11.021
   Tenekecioglu E, 2015, MINERVA MED, V106, P133
   Teragawa H, 2004, HEART, V90, P750, DOI 10.1136/hrt.2003.022269
   WALLIS RS, 1986, J IMMUNOL, V136, P193
   Westerterp M, 2012, CELL STEM CELL, V11, P195, DOI 10.1016/j.stem.2012.04.024
   WIEDERMANN JG, 1995, J AM COLL CARDIOL, V25, P1310, DOI 10.1016/0735-1097(94)00556-6
   Yagmur J, 2010, ACTA CARDIOL, V65, P515, DOI 10.1080/AC.65.5.2056237
   Zureik M, 2000, ARTERIOSCL THROM VAS, V20, P1622, DOI 10.1161/01.ATV.20.6.1622
NR 35
TC 26
Z9 26
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0001-5385
EI 1784-973X
J9 ACTA CARDIOL
JI Acta Cardiol.
PY 2017
VL 72
IS 5
BP 516
EP 521
DI 10.1080/00015385.2017.1299521
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FK1AR
UT WOS:000413212600002
PM 28853337
DA 2025-06-11
ER

PT J
AU Vercesi, AE
   Castilho, RF
   Kowaltowski, AJ
   Oliveira, HCF
AF Vercesi, Anibal E.
   Castilho, Roger F.
   Kowaltowski, Alicia J.
   Oliveira, Helena C. F.
TI Mitochondrial energy metabolism and redox state in dyslipidemias
SO IUBMB LIFE
LA English
DT Article; Proceedings Paper
CT 10th IUBMB Conference 2007
CY MAY 21-25, 2007
CL Salvador, BRAZIL
DE mitochondria; metabolic syndrome; hyperlipidemia; free radicals; K+
   channel; oxidative stress
ID LOW-DENSITY-LIPOPROTEIN; NADP(+)-DEPENDENT ISOCITRATE DEHYDROGENASE; COA
   REDUCTASE INHIBITORS; PERMEABILITY TRANSITION; REACTIVE OXYGEN;
   UNCOUPLING PROTEINS; CELL-DEATH; OXIDATIVE MODIFICATION;
   PYRIDINE-NUCLEOTIDES; ENDOTHELIAL-CELLS
AB Changes in mitochondrial function are intimately associated with metabolic diseases. Here, we review recent evidence relating alterations in mitochondrial energy metabolism, ion transport and redox state in hypercholesterolemia and hypertriglyceridemia. We focus mainly on changes in mitochondrial respiration, K+ and Ca2+ transport, reactive oxygen species generation and susceptibility to mitochondrial permeability transition.
C1 Univ Estadual Campinas, Fac Ciencias Med, Dept Patol Clin, BR-13083877 Campinas, SP, Brazil.
   Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-01498 Sao Paulo, Brazil.
   Univ Estadual Campinas, Inst Biol, Dept Fisiol & Biofis, Campinas, Brazil.
C3 Universidade Estadual de Campinas; Universidade de Sao Paulo;
   Universidade de Sao Paulo; Universidade Estadual de Campinas
RP Vercesi, AE (corresponding author), Univ Estadual Campinas, Fac Ciencias Med, Dept Patol Clin, BR-13083877 Campinas, SP, Brazil.
EM anibal@unicamp.br
RI Vercesi, Aníbal/C-8767-2012; Castilho, Roger/G-3906-2012; Kowaltowski,
   Alicia/H-8698-2012; Oliveira, Helena/C-1343-2013
OI Frigerio Castilho, Roger/0000-0003-2338-8717; Oliveira,
   Helena/0000-0003-0119-6992; Vercesi, Anibal Eugenio/0000-0001-6671-7125
CR AaltoSetala K, 1996, J LIPID RES, V37, P1802
   Alberici LC, 2003, J BIOENERG BIOMEMBR, V35, P451, DOI 10.1023/A:1027343915452
   Alberici LC, 2006, GASTROENTEROLOGY, V131, P1228, DOI 10.1053/j.gastro.2006.07.021
   Amaral MEC, 2002, HORM METAB RES, V34, P21, DOI 10.1055/s-2002-19962
   ASSMANN G, 1991, AM J CARDIOL, V68, pA13, DOI 10.1016/0002-9149(91)90854-E
   Bao S, 1998, DIABETES, V47, P1935, DOI 10.2337/diabetes.47.12.1935
   Brand MD, 2005, CELL METAB, V2, P85, DOI 10.1016/j.cmet.2005.06.002
   BROWN MS, 1986, SCIENCE, V232, P34, DOI 10.1126/science.3513311
   Catisti R, 1999, FEBS LETT, V464, P97, DOI 10.1016/S0014-5793(99)01677-4
   Chisolm GM, 2000, FREE RADICAL BIO MED, V28, P1815, DOI 10.1016/S0891-5849(00)00344-0
   Clark LT, 2003, AM HEART J, V145, P387, DOI 10.1067/mhj.2003.70
   Crompton M, 1999, BIOCHEM J, V341, P233, DOI 10.1042/0264-6021:3410233
   Facundo HTF, 2006, BBA-MOL BASIS DIS, V1762, P202, DOI 10.1016/j.bbadis.2005.06.003
   FACUNDO HTF, 2007, FREE RADIC BIOL MED, DOI DOI 10.1016/JFREERADBIOMED.2007.01.001
   FAGIAN MM, 1990, J BIOL CHEM, V265, P19955
   Ferranti R, 2003, FEBS LETT, V536, P51, DOI 10.1016/S0014-5793(03)00007-3
   Garlid KD, 2003, BBA-BIOENERGETICS, V1606, P23, DOI 10.1016/S0005-2728(03)00108-7
   Gaylor JL, 2002, BIOCHEM BIOPH RES CO, V292, P1139, DOI 10.1006/bbrc.2001.2008
   Gong DW, 1997, J BIOL CHEM, V272, P24129, DOI 10.1074/jbc.272.39.24129
   Green DR, 2004, SCIENCE, V305, P626, DOI 10.1126/science.1099320
   Grijalba MT, 1999, BIOCHEMISTRY-US, V38, P13279, DOI 10.1021/bi9828674
   Hidaka S, 2000, P SOC EXP BIOL MED, V224, P172, DOI 10.1046/j.1525-1373.2000.22417.x
   HOEK JB, 1988, BIOCHEM J, V254, P1
   Jo SH, 2001, J BIOL CHEM, V276, P16168, DOI 10.1074/jbc.M010120200
   Kaneta S, 2003, ATHEROSCLEROSIS, V170, P237, DOI 10.1016/S0021-9150(03)00301-0
   Kim JS, 2003, BIOCHEM BIOPH RES CO, V304, P463, DOI 10.1016/S0006-291X(03)00618-1
   Koh HJ, 2004, J BIOL CHEM, V279, P39968, DOI 10.1074/jbc.M402260200
   Korshunov SS, 1997, FEBS LETT, V416, P15, DOI 10.1016/S0014-5793(97)01159-9
   Kowaltowski AJ, 2001, FEBS LETT, V495, P12, DOI 10.1016/S0014-5793(01)02316-X
   Kubota T, 2004, BIOCHEM PHARMACOL, V67, P2175, DOI 10.1016/j.bcp.2004.02.037
   LAMB DJ, 1992, ATHEROSCLEROSIS, V92, P187, DOI 10.1016/0021-9150(92)90277-N
   LEHNINGER AL, 1978, P NATL ACAD SCI USA, V75, P1690, DOI 10.1073/pnas.75.4.1690
   Malloy M J, 2001, Adv Intern Med, V47, P111
   MANCINI M, 1991, AM J CARDIOL, V68, pA17, DOI 10.1016/0002-9149(91)90855-F
   MOREL DW, 1984, ARTERIOSCLEROSIS, V4, P357, DOI 10.1161/01.ATV.4.4.357
   Newmeyer DD, 2003, CELL, V112, P481, DOI 10.1016/S0092-8674(03)00116-8
   Nisoli E, 2000, DIABETES, V49, P319, DOI 10.2337/diabetes.49.3.319
   Oliveira HCF, 2004, FASEB J, V18, P278, DOI 10.1096/fj.04-2095fje
   Orrenius S, 2007, ANNU REV PHARMACOL, V47, P143, DOI 10.1146/annurev.pharmtox.47.120505.105122
   ROTHWELL NJ, 1979, NATURE, V281, P31, DOI 10.1038/281031a0
   ROTHWELL NJ, 1982, J PHYSIOL-LONDON, V328, P371, DOI 10.1113/jphysiol.1982.sp014270
   Samec S, 1999, DIABETES, V48, P436, DOI 10.2337/diabetes.48.2.436
   St-Pierre J, 2002, J BIOL CHEM, V277, P44784, DOI 10.1074/jbc.M207217200
   STOKES J, 1987, CIRCULATION, V75, P65
   Turrens JF, 2003, J PHYSIOL-LONDON, V552, P335, DOI 10.1113/jphysiol.2003.049478
   Velho JA, 2006, TOXICOLOGY, V219, P124, DOI 10.1016/j.tox.2005.11.007
   Vercesi AE, 2006, FRONT BIOSCI-LANDMRK, V11, P2554, DOI 10.2741/1990
   Vindis C, 2005, ARTERIOSCL THROM VAS, V25, P639, DOI 10.1161/01.ATV.0000154359.60886.33
   WALSH A, 1993, J LIPID RES, V34, P617
   WITZTUM JL, 1991, J CLIN INVEST, V88, P1785, DOI 10.1172/JCI115499
   Zhang DX, 2001, CIRC RES, V89, P1177, DOI 10.1161/hh2401.101752
   Zmijewski JW, 2005, AM J PHYSIOL-HEART C, V289, pH852, DOI 10.1152/ajpheart.00015.2005
   ZORATTI M, 1995, BBA-REV BIOMEMBRANES, V1241, P139, DOI 10.1016/0304-4157(95)00003-A
NR 53
TC 19
Z9 20
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1521-6543
EI 1521-6551
J9 IUBMB LIFE
JI IUBMB Life
PY 2007
VL 59
IS 4-5
BP 263
EP 268
DI 10.1080/15216540601178091
PG 6
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Biochemistry & Molecular Biology; Cell Biology
GA 171SX
UT WOS:000246756800018
PM 17505963
OA Bronze
DA 2025-06-11
ER

PT J
AU Bulboaca, A
   Bolboaca, SD
   Suci, S
AF Bulboaca, Adriana
   Bolboaca, Sorana D.
   Suci, Soimita
TI Protective effect of curcumin in fructose-induced metabolic syndrome and
   in streptozotocin-induced diabetes in rats
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Article
DE Curcumin; Diabetes mellitus; Fructose; Metabolic syndrome Oxidative
   stress; Streptozotocin-induced diabetes
ID ROSTRAL VENTROLATERAL MEDULLA; OXIDATIVE STRESS; NITRIC-OXIDE;
   HYPERTENSION; GLUCOSE; INSULIN; MALONDIALDEHYDE; GLUTATHIONE;
   INHIBITION; CONTRIBUTE
AB Objective: The aim of this study was to investigate the effect of pre-treatment with curcumin on metabolic changes induced by two different pathophysiological mechanisms in rats (fructose diet and streptozotocin (STZ)-induced diabetes mellitus).
   Materials and Methods: Five groups with 10 rats per group were investigated: control group (healthy rats), fructose diet groups without any pre-treatment (FD), fructose diet groups with curcumin pre-treatment (FDC), STZ-induced diabetes mellitus without any pre-treatment (SID) and STZ-induced diabetes mellitus with curcumin pre-treatment (SIDC). Systolic blood pressure, and several metabolic and oxidative stress parameters were assessed.
   Results: Systolic blood pressure significantly increased in all groups compared with control group (P<0.001), with significantly lower values on groups with curcumin pre-treatment compared with the group without any pre-treatment and same inducement (FDS vs. FD P<0.0001, SIDC vs. SID P<0.0001). High-density lipoprotein (HDL)-cholesterol was significantly lower in all groups compared with control group (P<0.05) while triglycerides (P<0.05), aspartate aminotransferase (AST, P<0.0001) and alanine aminotransferase (ALT, P<0.0001) were significantly higher. Within the group with same induction, curcumin pre-treatment significantly improved metabolic (total cholesterol, glycaemia, triglycerides, AST, ALT; P<0.05) and oxidative stress parameters (total oxidative status (NOx), Thiol, and malondialdehyde (MDA), P<0.02) compared to untreated groups.
   Conclusion: The pre-treatment with curcumin in our experimental models significantly improved metabolic (total cholesterol, triglycerides, AST and ALT) as well as oxidative stress parameters (MDA, NOx, and Thiol) in both fructose diet and in STZ-induced diabetes in rats. These properties of curcumin may serve to improve the metabolic and oxidative stress conditions in patients with these pathological features.
C1 [Bulboaca, Adriana] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Dept Pathophysiol, Victor Babes St 2-4, Cluj Napoca 400012, Romania.
   [Bolboaca, Sorana D.] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Dept Biostat & Med Informat, Louis Pasteur St 6, Cluj Napoca 400349, Romania.
   [Suci, Soimita] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Dept Physiol, Clinicilor St 1, Cluj Napoca 400006, Romania.
C3 Iuliu Hatieganu University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy; Iuliu Hatieganu University of
   Medicine & Pharmacy
RP Bolboaca, SD (corresponding author), Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Dept Biostat & Med Informat, 6 Louis Pasteur, Cluj Napoca 400349, Romania.
EM sbolboaca@umfcluj.ro
RI Bulboaca, Adriana-Elena/S-8093-2017; Suciu, Şoimiţa/S-8470-2017;
   Bolboaca, Sorana D./E-4457-2010
OI Suciu, Soimita Mihaela/0000-0003-2208-5132; Bolboaca, Sorana
   D./0000-0002-2342-4311
CR Abolfathi AA, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/740671
   Aggarwal BB, 2003, ANTICANCER RES, V23, P363
   Aggarwal BB, 2009, INT J BIOCHEM CELL B, V41, P40, DOI 10.1016/j.biocel.2008.06.010
   Ahsan H, 1999, CHEM-BIOL INTERACT, V121, P161, DOI 10.1016/S0009-2797(99)00096-4
   Al-Rubaei Z M Malik, 2014, Pak J Biol Sci, V17, P1237, DOI 10.3923/pjbs.2014.1237.1241
   Alimohammadi S, 2013, DIAGN PATHOL, V8, DOI 10.1186/1746-1596-8-137
   Amin F, 2015, J CARDIOVASC PHARM, V65, P176, DOI 10.1097/FJC.0000000000000179
   Amr AA, 2014, PLOS ONE, V9
   Bengmark S, 2009, NUTR HOSP, V24, P273
   Chattopadhyay I, 2004, CURR SCI INDIA, V87, P44
   Cosenzi A, 2002, KIDNEY BLOOD PRESS R, V25, P363, DOI 10.1159/000068694
   Ferreira FD, 2013, SCI WORLD J, DOI 10.1155/2013/343804
   Fisher-Wellman KH, 2013, FREE RADICAL BIO MED, V65, P1201, DOI 10.1016/j.freeradbiomed.2013.09.008
   Francik R, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/457085
   Goss SPA, 1999, FREE RADICAL RES, V31, P597, DOI 10.1080/10715769900301171
   Gupta SK, 2011, J OCUL PHARMACOL TH, V27, P123, DOI 10.1089/jop.2010.0123
   Haluzík M, 1998, PHYSIOL RES, V47, P337
   Hassanin A, 2014, EXP THER MED, V8, P1551, DOI 10.3892/etm.2014.1963
   Hu GX, 2013, PLOS ONE, V8, DOI [10.1371/journal.pone.0049976, 10.1371/journal.pone.0060700]
   HU ML, 1994, METHOD ENZYMOL, V233, P380
   Husain K, 2002, BBA-MOL BASIS DIS, V1587, P75, DOI 10.1016/S0925-4439(02)00070-4
   HWANG IS, 1987, HYPERTENSION, V10, P512, DOI 10.1161/01.HYP.10.5.512
   JANERO DR, 1990, FREE RADICAL BIO MED, V9, P515, DOI 10.1016/0891-5849(90)90131-2
   Jayaprakasha GK, 2006, FOOD CHEM, V98, P720, DOI 10.1016/j.foodchem.2005.06.037
   Kawamura T, 2004, HYPERTENS RES, V27, P61, DOI 10.1291/hypres.27.61
   Kawasaki T, 2009, J NUTR, V139, P2067, DOI 10.3945/jn.109.105858
   Kishi T, 2013, HYPERTENS RES, V36, P845, DOI 10.1038/hr.2013.73
   LUNG CC, 1993, LIFE SCI, V52, P329
   Mamikutty N, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/263897
   Minaiyan M, 2011, IRAN J BASIC MED SCI, V14, P436
   Mohammad A, 2010, INDIAN J PHARMACOL, V42, P78, DOI 10.4103/0253-7613.64501
   Musial DC, 2013, DIABETES VASC DIS RE, V10, P498, DOI 10.1177/1479164113496441
   Nagajyothi F, 2012, PARASITOL RES, V110, P2491, DOI 10.1007/s00436-011-2790-9
   NATHAN C, 1994, CELL, V78, P915, DOI 10.1016/0092-8674(94)90266-6
   Negi PS, 1999, J AGR FOOD CHEM, V47, P4297, DOI 10.1021/jf990308d
   Volpe CMO, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/479587
   Parvui AE, 2014, J PHYSIOL PHARMACOL, V65, P309
   ROKUTAN K, 1989, EUR J BIOCHEM, V179, P233, DOI 10.1111/j.1432-1033.1989.tb14546.x
   ROSSINI AA, 1977, P NATL ACAD SCI USA, V74, P2485, DOI 10.1073/pnas.74.6.2485
   Shahi MM, 2011, ADV PHARM BULL, V1, P81, DOI 10.5681/apb.2011.012
   Sherajee SJ, 2013, EUR J PHARMACOL, V720, P63, DOI 10.1016/j.ejphar.2013.10.051
   Soucek M, 2001, Vnitr Lek, V47, P315
   Spruss A, 2011, ANTIOXID REDOX SIGN, V14, P2121, DOI 10.1089/ars.2010.3263
   Srinivasan K, 2013, FOOD FUNCT, V4, P503, DOI 10.1039/c2fo30249g
   Suganthi R, 2007, J MED FOOD, V10, P149, DOI 10.1089/jmf.2005.058
   Suryanarayana P, 2007, MED SCI MONITOR, V13, pBR286
   Tappy L, 2010, NUTRITION, V26, P1044, DOI 10.1016/j.nut.2010.02.014
   Wickenberg J, 2010, NUTR J, V9, DOI 10.1186/1475-2891-9-43
   Wu KLH, 2014, HYPERTENSION, V64, P815, DOI 10.1161/HYPERTENSIONAHA.114.03777
   Wu KLH, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-212
   Yagl K, 1984, METHOD ENZYMOL, V105, P28
NR 51
TC 32
Z9 33
U1 0
U2 14
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD JUN
PY 2016
VL 19
IS 6
BP 585
EP 593
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA DR8VX
UT WOS:000380177400002
PM 27482338
DA 2025-06-11
ER

PT J
AU Kuhad, A
   Chopra, K
AF Kuhad, Anurag
   Chopra, Kanwaljit
TI Highlights from the 3rd international conference on polyphenols and
   health
SO DRUGS OF THE FUTURE
LA English
DT Review
ID FRENCH PARADOX
AB The 3rd International Conference on Polyphenols and Health (ICPH), held in Kyoto, Japan, on November 25-28, 2007, focused on recent advances in polyphenolic research in different fields, from natural characterization, chemistry, bioavailability, metabolism, biological effects, formulations, epidemiological and interventional studies to clinical trials. The main focus of the conference was the molecular mechanism underlying pharmaceutical application of polyphenols in a plethora of disease conditions, including inflammation, cancer, metabolic syndrome, diabetes, allergy, cognition and oxidative stress-related pathologies.
C1 [Kuhad, Anurag; Chopra, Kanwaljit] Panjab Univ, Pharmacol Res Lab, Univ Inst Pharmaceut Sci, UCG Ctr Adv Studies, Chandigarh 160014, India.
C3 Panjab University
RP Kuhad, A (corresponding author), Panjab Univ, Pharmacol Res Lab, Univ Inst Pharmaceut Sci, UCG Ctr Adv Studies, Chandigarh 160014, India.
EM anurag_pu@yahoo.com
OI Chopra, Kanwaljit/0000-0001-5898-6093
CR AABY K, 2007, 3 INT C POL HLTH ICP
   ACTISGORETTA L, 2007, 3 INT C POL HLTH ICP
   AGGARWAL BB, 2007, 3 INT C POL HLTH ICP
   AKIYAMA H, 2007, 3 INT C POL HLTH ICP
   AKIYAMA K, 2007, 3 INT C POL HLTH ICP
   AKIYAMA S, 2007, 3 INT C POL HLTH ICP
   ALAWAN TA, 2007, 3 INT C POL HLTH ICP
   ANDERSON RC, 2007, 3 INT C POL HLTH ICP
   AOYAGI K, 2007, 3 INT C POL HLTH ICP
   ARAI Y, 2007, 3 INT C POL HLTH ICP
   ASHIDA H, 2007, 3 INT C POL HLTH ICP
   AUCLAIR S, 2007, 3 INT C POL HLTH ICP
   AUGUSTIN K, 2007, 3 INT C POL HLTH ICP
   AUGUSTIN S, 2007, 3 INT C POL HLTH ICP
   AZUMA K, 2007, 3 INT C POL HLTH ICP
   BABA S, 2007, 3 INT C POL HLTH ICP
   BAE JY, 2007, 3 INT C POL HLTH ICP
   BALZER J, 2007, 3 INT C POL HLTH ICP
   BETTUZZI S, 2007, 3 INT C POL HLTH ICP
   Biesalski HK, 2007, CURR OPIN CLIN NUTR, V10, P724, DOI 10.1097/MCO.0b013e3282f0cef2
   BORGE GA, 2007, 3 INT C POL HLTH ICP
   BRITO PM, 2007, 3 INT C POL HLTH ICP
   Chawla Raghav, 2004, BMJ, V329, P1308, DOI 10.1136/bmj.329.7478.1308-g
   CHEN J, 2007, 3 INT C POL HLTH ICP
   CHIBA H, 2007, 3 INT C POL HLTH ICP
   CHOI EJ, 2007, 3 INT C POL HLTH ICP
   CHOI SY, 2007, 3 INT C POL HLTH ICP
   CHONPATHOMPIKUL.P, 2007, 3 INT C POL HLTH ICP
   CONNOR CA, 2007, 3 INT C POL HLTH ICP
   COOPER KA, 2007, 3 INT C POL HLTH ICP
   CORDER R, 2007, 3 INT C POL HLTH ICP
   CURTIS AD, 2005, J THROMB HAEMOST, V3, P346
   DAGLIA M, 2007, 3 INT C POL HLTH ICP
   DARRA E, 2007, 3 INT C POL HLTH ICP
   DONOVAN JL, 2007, 3 INT C POL HLTH ICP
   DUBOS C, 2007, 3 INT C POL HLTH ICP
   DUTHIE SJ, 2007, 3 INT C POL HLTH ICP
   DVORAKOVA M, 2007, 3 INT C POL HLTH ICP
   EZIO B, 2007, 3 INT C POL HLTH ICP
   Ferrières J, 2004, HEART, V90, P107, DOI 10.1136/heart.90.1.107
   FORESTER SC, 2007, 3 INT C POL HLTH ICP
   FRANK J, 2007, 3 INT C POL HLTH ICP
   FUKUDA I, 2007, 3 INT C POL HLTH ICP
   FUKUMITSU S, 2007, 3 INT C POL HLTH ICP
   GARCIA P, 2007, 3 INT C POL HLTH ICP
   GERHAUSER C, 2007, 3 INT C POL HLTH ICP
   GONZALESANJOSE ML, 2007, 3 INT C POL HLTH ICP
   GONZALEZ N, 2007, 3 INT C POL HLTH ICP
   GORDON MH, 2007, 3 INT C POL HLTH ICP
   GUIDO LF, 2007, 3 INT C POL HLTH ICP
   GUPTA RC, 2007, 3 INT C POL HLTH ICP
   HAAN B, 2007, 3 INT C POL HLTH ICP
   HABAUZIT V, 2007, 3 INT C POL HLTH ICP
   HACKMAN RM, 2007, 3 INT C POL HLTH ICP
   HALLMANN EW, 2007, 3 INT C POL HLTH ICP
   HAMAUZV Y, 2007, 3 INT C POL HLTH ICP
   HAN D, 2007, 3 INT C POL HLTH ICP
   HAN K, 2007, 3 INT C POL HLTH ICP
   HAQUE AM, 2007, 3 INT C POL HLTH ICP
   HARAMOTO M, 2007, 3 INT C POL HLTH ICP
   HASHIMOTO T, 2007, 3 INT C POL HLTH ICP
   HASSAN M, 2007, 3 INT C POL HLTH ICP
   HAWISET T, 2007, 3 INT C POL HLTH ICP
   HIDAIGO M, 2007, 3 INT C POL HLTH ICP
   HIRAI S, 2007, 3 INT C POL HLTH ICP
   HIRAI T, 2007, 3 INT C POL HLTH ICP
   HOLLMAN PC, 2007, 3 INT C POL HLTH ICP
   HORINAKA M, 2007, 3 INT C POL HLTH ICP
   HOU D, 2007, 3 INT C POL HLTH ICP
   HURST RD, 2007, 3 INT C POL HLTH ICP
   ICHIYANAGI T, 2007, 3 INT C POL HLTH ICP
   IDE T, 2007, 3 INT C POL HLTH ICP
   IGARASHI K, 2007, 3 INT C POL HLTH ICP
   IKUSHIRO S, 2007, 3 INT C POL HLTH ICP
   INOUE H, 2007, 3 INT C POL HLTH ICP
   INOUE M, 2007, 3 INT C POL HLTH ICP
   INOYE K, 2007, 3 INT C POL HLTH ICP
   ISHIKAWA YT, 2007, 3 INT C POL HLTH ICP
   ISMAIL A, 2007, 3 INT C POL HLTH ICP
   ITO H, 2007, 3 INT C POL HLTH ICP
   IWAI K, 2007, 3 INT C POL HLTH ICP
   IWATA R, 2007, 3 INT C POL HLTH ICP
   JAFFRI MJ, 2007, 3 INT C POL HLTH ICP
   JAKESEVIC M, 2007, 3 INT C POL HLTH ICP
   JALIL AM, 2007, 3 INT C POL HLTH ICP
   JAN KC, 2007, 3 INT C POL HLTH ICP
   JANG JH, 2007, 3 INT C POL HLTH ICP
   JEON YH, 2007, 3 INT C POL HLTH ICP
   JEONG SW, 2007, 3 INT C POL HLTH ICP
   JIN Y, 2007, 3 INT C POL HLTH ICP
   JITTIWAT J, 2007, 3 INT C POL HLTH ICP
   JOSEPH JA, 2007, 3 INT C POL HLTH ICP
   Joseph JA, 2007, ANN NY ACAD SCI, V1100, P470, DOI 10.1196/annals.1395.052
   KAGAWA T, 2007, 3 INT C POL HLTH ICP
   KANO S, 2007, 3 INT C POL HLTH ICP
   KASAI K, 2007, 3 INT C POL HLTH ICP
   KASHIWADA D, 2007, 3 INT C POL HLTH ICP
   KASHIWAKURA D, 2007, 3 INT C POL HLTH ICP
   KATO Y, 2007, 3 INT C POL HLTH ICP
   KATSUMATA S, 2007, 3 INT C POL HLTH ICP
   KAWAI Y, 2007, 3 INT C POL HLTH ICP
   KAWAMOTO E, 2007, 3 INT C POL HLTH ICP
   KAY CD, 2007, 3 INT C POL HLTH ICP
   KIM CJ, 2007, 3 INT C POL HLTH ICP
   KIM D, 2007, 3 INT C POL HLTH ICP
   KIM M, 2007, 3 INT C POL HLTH ICP
   KISO Y, 2007, 3 INT C POL HLTH ICP
   KNUDSEN IP, 2007, 3 INT C POL HLTH ICP
   KOBAYASHI Y, 2007, 3 INT C POL HLTH ICP
   KOBORI M, 2007, 3 INT C POL HLTH ICP
   KONISHI Y, 2007, 3 INT C POL HLTH ICP
   KORZENIOWSKA M, 2007, 3 INT C POL HLTH ICP
   KROYER GT, 2007, 3 INT C POL HLTH ICP
   KUBOTA E, 2007, 3 INT C POL HLTH ICP
   KUHAD A, 2007, 3 INT C POL HLTH ICP
   KULEVANOVA S, 2007, 3 INT C POL HLTH ICP
   KUMAMOTO T, 2007, 3 INT C POL HLTH ICP
   KUNDU JK, 2007, 3 INT C POL HLTH ICP
   KURASHIGE Y, 2007, 3 INT C POL HLTH ICP
   KURATA R, 2007, 3 INT C POL HLTH ICP
   KUROGI R, 2007, 3 INT C POL HLTH ICP
   LAFAY S, 2007, 3 INT C POL HLTH ICP
   LEE CY, 2007, 3 INT C POL HLTH ICP
   LEE J, 2007, 3 INT C POL HLTH ICP
   LEE M, 2007, 3 INT C POL HLTH ICP
   LEE TK, 2007, 3 INT C POL HLTH ICP
   LEE YC, 2007, 3 INT C POL HLTH ICP
   LEGER CL, 2007, 3 INT C POL HLTH ICP
   LING LT, 2007, 3 INT C POL HLTH ICP
   LIU DL, 2007, 3 INT C POL HLTH ICP
   LOKE WM, 2007, 3 INT C POL HLTH ICP
   LU Y, 2007, 3 INT C POL HLTH ICP
   MACKENZIE GG, 2007, 3 INT C POL HLTH ICP
   MAHER PA, 2007, 3 INT C POL HLTH ICP
   MARAM SS, 2007, 3 INT C POL HLTH ICP
   MARIOTTO S, 2007, 3 INT C POL HLTH ICP
   MARQUES VX, 2007, 3 INT C POL HLTH ICP
   MEAN MN, 2007, ENV HLTH PERSPECT, V115, pA582
   MEDINAREMON A, 2007, 3 INT C POL HLTH ICP
   MICHIHARA S, 2007, 3 INT C POL HLTH ICP
   MILENKOVIC D, 2007, 3 INT C POL HLTH ICP
   MITCHELL AE, 2007, 3 INT C POL HLTH ICP
   MIURA T, 2007, 3 INT C POL HLTH ICP
   MIYAMOTO S, 2007, 3 INT C POL HLTH ICP
   MIYAZAWA M, 2007, 3 INT C POL HLTH ICP
   MOHAMED S, 2007, 3 INT C POL HLTH ICP
   Moreiras-Varela O, 1989, Eur J Clin Nutr, V43 Suppl 2, P83
   MORI A, 2007, 3 INT C POL HLTH ICP
   MUELLER M, 2007, 3 INT C POL HLTH ICP
   MULLEN W, 2007, 3 INT C POL HLTH ICP
   MURESAN A, 2007, 3 INT C POL HLTH ICP
   MUROTA K, 2007, 3 INT C POL HLTH ICP
   MURSU J, 2007, 3 INT C POL HLTH ICP
   NADOVA S, 2007, 3 INT C POL HLTH ICP
   NAGAKA Y, 2007, 3 INT C POL HLTH ICP
   NAKAMURA Y, 2007, 3 INT C POL HLTH ICP
   NATSUME Y, 2007, 3 INT C POL HLTH ICP
   Nicolson GL, 2007, J CELL BIOCHEM, V100, P1352, DOI 10.1002/jcb.21247
   NISHIKAWA T, 2007, 3 INT C POL HLTH ICP
   NISHIMATSU S, 2007, 3 INT C POL HLTH ICP
   NISHIUMI S, 2007, 3 INT C POL HLTH ICP
   NOHARA T, 2007, 3 INT C POL HLTH ICP
   NONAKA T, 2007, 3 INT C POL HLTH ICP
   NURMI T, 2007, 3 INT C POL HLTH ICP
   OI N, 2007, 3 INT C POL HLTH ICP
   OJHA S, 2007, 3 INT C POL HLTH ICP
   OKAME T, 2007, 3 INT C POL HLTH ICP
   OKAMOTO M, 2007, 3 INT C POL HLTH ICP
   OKUNO Y, 2007, 3 INT C POL HLTH ICP
   OSZMANSKI J, 2007, 3 INT C POL HLTH ICP
   OTAKI N, 2007, 3 INT C POL HLTH ICP
   OTTAVIANI JI, 2007, 3 INT C POL HLTH ICP
   PANGPOOKIEW P, 2007, 3 INT C POL HLTH ICP
   PANOVSKA TK, 2007, 3 INT C POL HLTH ICP
   PARK T, 2007, 3 INT C POL HLTH ICP
   PENALVO JL, 2007, 3 INT C POL HLTH ICP
   PFITSCHER A, 2007, 3 INT C POL HLTH ICP
   PHACHONPAI W, 2007, 3 INT C POL HLTH ICP
   PIPARO EL, 2007, 3 INT C POL HLTH ICP
   PISKULA MK, 2007, 3 INT C POL HLTH ICP
   POLLARD SE, 2007, 3 INT C POL HLTH ICP
   POQUET L, 2007, 3 INT C POL HLTH ICP
   POULSEN L, 2007, 3 INT C POL HLTH ICP
   PUANGPRONPITAG D, 2007, 3 INT C POL HLTH ICP
   PUEL C, 2007, 3 INT C POL HLTH ICP
   RAHMAN MM, 2007, 3 INT C POL HLTH ICP
   RAMALAKSHMI K, 2007, 3 INT C POL HLTH ICP
   REIN MJ, 2007, 3 INT C POL HLTH ICP
   ROGI T, 2007, 3 INT C POL HLTH ICP
   ROMIERCROUZET B, 2007, 3 INT C POL HLTH ICP
   ROUSSEL A, 2007, 3 INT C POL HLTH ICP
   Rozin P, 2003, PSYCHOL SCI, V14, P450, DOI 10.1111/1467-9280.02452
   SABAU LI, 2007, 3 INT C POL HLTH ICP
   SAENGHONG N, 2007, 3 INT C POL HLTH ICP
   SAKAGAMI H, 2007, 3 INT C POL HLTH ICP
   SAKAKIBARA H, 2007, 3 INT C POL HLTH ICP
   SAKAO K, 2007, 3 INT C POL HLTH ICP
   SAKURAI T, 2007, 3 INT C POL HLTH ICP
   SALLEH LM, 2007, 3 INT C POL HLTH ICP
   SARDA MU, 2007, 3 INT C POL HLTH ICP
   SARRIAS AG, 2007, 3 INT C POL HLTH ICP
   SCALBERT A, 2007, 3 INT C POL HLTH ICP
   SCHINIKERTH VB, 2007, 3 INT C POL HLTH ICP
   SCHNORR O, 2007, 3 INT C POL HLTH ICP
   SEKI T, 2007, 3 INT C POL HLTH ICP
   SELAMAT J, 2007, 3 INT C POL HLTH ICP
   SEO B, 2007, 3 INT C POL HLTH ICP
   SHIBA Y, 2007, 3 INT C POL HLTH ICP
   SHIRAI Y, 2007, 3 INT C POL HLTH ICP
   SHOJI T, 2007, 3 INT C POL HLTH ICP
   SIRIWAT S, 2007, 3 INT C POL HLTH ICP
   Soobrattee MA, 2006, BIOFACTORS, V27, P19, DOI 10.1002/biof.5520270103
   SPENCER JPE, 2007, 3 INT C POL HLTH ICP
   STEFFEN Y, 2007, 3 INT C POL HLTH ICP
   STEILING H, 2007, 3 INT C POL HLTH ICP
   STEINER C, 2007, 3 INT C POL HLTH ICP
   STEVANOVIC T, 2007, 3 INT C POL HLTH ICP
   SUCIU S, 2007, 3 INT C POL HLTH ICP
   SUGAWARA T, 2007, 3 INT C POL HLTH ICP
   SUGIYAMA H, 2007, 3 INT C POL HLTH ICP
   SUMIN M, 2007, 3 INT C POL HLTH ICP
   SUNAGAWA T, 2007, 3 INT C POL HLTH ICP
   SURH Y, 2007, 3 INT C POL HLTH ICP
   TAKEMURA H, 2007, 3 INT C POL HLTH ICP
   TAMURA M, 2007, 3 INT C POL HLTH ICP
   TATEMATSU K, 2007, 3 INT C POL HLTH ICP
   TAYLOR MJ, 2007, 3 INT C POL HLTH ICP
   THIPKAEW C, 2007, 3 INT C POL HLTH ICP
   TOMASBARBERAN FA, 2007, 3 INT C POL HLTH ICP
   TOMIMORI N, 2007, 3 INT C POL HLTH ICP
   TRIBOLO S, 2007, 3 INT C POL HLTH ICP
   TRUONG MT, 2007, 3 INT C POL HLTH ICP
   TRZECIAKIEWICZ A, 2007, 3 INT C POL HLTH ICP
   TSAI TH, 2007, 3 INT C POL HLTH ICP
   TSEVEOIDOV O, 2007, 3 INT C POL HLTH ICP
   TSIANI E, 2007, 3 INT C POL HLTH ICP
   TSUBONO Y, 2007, 3 INT C POL HLTH ICP
   TSUDA T, 2007, 3 INT C POL HLTH ICP
   Tur JA, 2005, PUBLIC HEALTH NUTR, V8, P275, DOI 10.1079/PHN2004693
   TZOUNIS X, 2007, 3 INT C POL HLTH ICP
   UABUNDIT N, 2007, 3 INT C POL HLTH ICP
   UDAGAWA YU, 2007, 3 INT C POL HLTH ICP
   UEDA M, 2007, 3 INT C POL HLTH ICP
   UEKUSA Y, 2007, 3 INT C POL HLTH ICP
   UESATO S, 2007, 3 INT C POL HLTH ICP
   ULRICHOVA J, 2007, 3 INT C POL HLTH ICP
   UMEGAKI K, 2007, 3 INT C POL HLTH ICP
   VAFEIADOU K, 2007, 3 INT C POL HLTH ICP
   VAUZOUR D, 2007, 3 INT C POL HLTH ICP
   VIGUERA CG, 2007, 3 INT C POL HLTH ICP
   VINSON JA, 2007, 3 INT C POL HLTH ICP
   VITA JA, 2007, 3 INT C POL HLTH ICP
   WALLS R, 2007, 3 INT C POL HLTH ICP
   WANG R, 2007, 3 INT C POL HLTH ICP
   WATANABE S, 2007, 3 INT C POL HLTH ICP
   WEIN S, 2007, 3 INT C POL HLTH ICP
   WIEGAND H, 2007, 3 INT C POL HLTH ICP
   WOJDYLO A, 2007, 3 INT C POL HLTH ICP
   WU H, 2007, 3 INT C POL HLTH ICP
   YAMAMOTO MM, 2007, 3 INT C POL HLTH ICP
   YANG CS, 2007, 3 INT C POL HLTH ICP
   YASUDA A, 2007, 3 INT C POL HLTH ICP
   YASUDA M, 2007, 3 INT C POL HLTH ICP
   YOSHINO S, 2007, 3 INT C POL HLTH ICP
   ZARBAN A, 2007, 3 INT C POL HLTH ICP
NR 265
TC 4
Z9 5
U1 0
U2 2
PU PROUS SCIENCE, SAU-THOMSON REUTERS
PI BARCELONA
PA 398 PROVENCA, 08025 BARCELONA, SPAIN
SN 0377-8282
EI 2013-0368
J9 DRUG FUTURE
JI Drug Future
PD MAR
PY 2008
VL 33
IS 3
BP 249
EP 287
PG 39
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 284GK
UT WOS:000254694700009
DA 2025-06-11
ER

PT J
AU Takayanagi, Y
   Obana, A
   Muto, S
   Asaoka, R
   Tanito, M
   Ermakov, IV
   Bernstein, PS
   Gellermann, W
AF Takayanagi, Yuji
   Obana, Akira
   Muto, Shigeki
   Asaoka, Ryo
   Tanito, Masaki
   Ermakov, Igor V.
   Bernstein, Paul S.
   Gellermann, Werner
TI Relationships between Skin Carotenoid Levels and Metabolic Syndrome
SO ANTIOXIDANTS
LA English
DT Article
DE metabolic syndrome; health examination population; skin carotenoids;
   oxidative stress; Veggie Meter
ID 3RD NATIONAL-HEALTH; CIGARETTE-SMOKING; SERUM CAROTENOIDS; LOWER
   PREVALENCE; MACULAR PIGMENT; DIETARY-INTAKE; US ADULTS; ANTIOXIDANT;
   PLASMA; LUTEIN
AB Carotenoids have potential antioxidant and anti-inflammatory effects; their protective roles are of particular interest in the pathogenesis of metabolic syndrome (MetS). The reflection spectroscopy method has been recently developed to noninvasively measure skin carotenoid (SC) levels, which highly correlates with serum concentration of carotenoids. The relationship between SC levels and metabolic syndrome has been investigated. We aimed to identify the differences in patient characteristics and SC levels between participants with and without MetS in a large health examination population. In addition, the relationships between SC levels and various clinical parameters related to MetS were investigated. SC levels were measured using a reflection spectroscopy. A total of 1812 Japanese participants (859 male, 953 female; mean age +/- standard deviation (SD), 57.8 +/- 11.0 years) comprised the study population, i.e., participants with MetS (n = 151) and those without MetS (n = 1661). Multivariate logistic regression analysis was performed to identify variables associated with MetS. Compared to controls (377.3 +/- 122.8), SC indices were significantly lower in patients with MetS (340.7 +/- 112.5, p = 0.0004). Multivariate models also suggested that lower SC was significantly associated with MetS after adjustment for age, sex, smoking habit, and other potential risk factors for MetS. Furthermore, male gender (p < 0.0001), smoking habit (p < 0.0001) and worse lipid profiles (i.e., serum triglyceride (r = -0.1039, p < 0.0001), high-density lipoprotein (r = 0.1259, p < 0.0001), and usage of hypolipidemic agents (p = 0.0340)) were significantly associated with lower SC levels. The current study indicated that lower SC levels were significantly associated with MetS. This study highlights the antioxidant capacity of carotenoids in patients with MetS and the clinical utility of non-invasive and cost-effective SC measurement to detect participants who are at risk of developing MetS in a large population.
C1 [Takayanagi, Yuji; Tanito, Masaki] Shimane Univ, Fac Med, Dept Ophthalmol, Izumo, Shimane 6938501, Japan.
   [Obana, Akira; Asaoka, Ryo] Seirei Hamamatsu Gen Hosp, Dept Ophthalmol, Hamamatsu, Shizuoka 4308558, Japan.
   [Obana, Akira] Hamamatsu Univ, Sch Med, Preeminent Med Photon Educ & Res Ctr, Dept Med Spect,Inst Med Photon Res, Hamamatsu, Shizuoka 4313192, Japan.
   [Muto, Shigeki] Seirei Social Welf Community, Seirei Ctr Hlth Promot & Prevent Med, Hamamatsu, Shizuoka 4300906, Japan.
   [Ermakov, Igor V.; Gellermann, Werner] Longev Link Corp, Salt Lake City, UT 84108 USA.
   [Bernstein, Paul S.] Univ Utah, Sch Med, Moran Eye Ctr, Dept Ophthalmol & Visual Sci, Salt Lake City, UT 84132 USA.
C3 Shimane University; Hamamatsu University School of Medicine; Utah System
   of Higher Education; University of Utah
RP Obana, A (corresponding author), Seirei Hamamatsu Gen Hosp, Dept Ophthalmol, Hamamatsu, Shizuoka 4308558, Japan.; Obana, A (corresponding author), Hamamatsu Univ, Sch Med, Preeminent Med Photon Educ & Res Ctr, Dept Med Spect,Inst Med Photon Res, Hamamatsu, Shizuoka 4313192, Japan.
EM y.takayanagi1008@gmail.com; obana@sis.seirei.or.jp;
   smuto@sis.seirei.or.jp; ryoasa0120@googlemail.com;
   mtanito@med.shimane-u.ac.jp; iv.ermakov@outlook.com;
   paul.bernstein@hsc.utah.edu; wbgellermann@gmail.com
OI Obana, Akira/0000-0001-7930-3618; Bernstein, Paul/0000-0002-4228-7666
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
   [19H01114, 18KK0253, 20K09784]; Strategic Promotion for practical
   application of Innovative medical Technology (TR-SPRINT) from the Japan
   Agency for Medical Research and Development (AMED); Japan Science and
   Technology Agency; National Eye Institute [EY11600, EY14800]; Research
   to Prevent Blindness
FX R.A. received grants as follows: grants (19H01114, 18KK0253, and
   20K09784) from the Ministry of Education, Culture, Sports, Science and
   Technology of Japan (RA), The Translational Research program; Strategic
   Promotion for practical application of Innovative medical Technology
   (TR-SPRINT) from the Japan Agency for Medical Research and Development
   (AMED) (RA), grant AIP acceleration research from the Japan Science and
   Technology Agency (RA). P.S.B. received grants as follows: National Eye
   Institute grants EY11600 and EY14800. And an unrestricted departmental
   grant from Research to Prevent Blindness (there is no grant number).
   Other authors received no grands.
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Aune D, 2018, AM J CLIN NUTR, V108, P1069, DOI 10.1093/ajcn/nqy097
   Bernstein PS, 2013, INVEST OPHTH VIS SCI, V54, P4034, DOI 10.1167/iovs.13-11891
   Beydoun MA, 2019, NUTR REV, V77, P32, DOI 10.1093/nutrit/nuy044
   Beydoun MA, 2011, J NUTR, V141, P903, DOI 10.3945/jn.110.136580
   Böhm V, 2021, NUTR REV, V79, P544, DOI 10.1093/nutrit/nuaa008
   Bohn T, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8060179
   CLEVIDENCE BA, 1993, METHOD ENZYMOL, V214, P33
   Connor WE, 2007, INVEST OPHTH VIS SCI, V48, P4226, DOI 10.1167/iovs.06-1275
   Conrady CD, 2017, INVEST OPHTH VIS SCI, V58, P3616, DOI 10.1167/iovs.17-21818
   Darvin ME, 2009, EXP DERMATOL, V18, P1060, DOI 10.1111/j.1600-0625.2009.00946.x
   Ermakov IV, 2018, ARCH BIOCHEM BIOPHYS, V646, P46, DOI 10.1016/j.abb.2018.03.033
   Ermakov IV, 2015, ARCH BIOCHEM BIOPHYS, V572, P101, DOI 10.1016/j.abb.2015.01.020
   Ermakov IV, 2013, J BIOPHOTONICS, V6, P793, DOI 10.1002/jbio.201200195
   Ermakov IV, 2012, J BIOPHOTONICS, V5, P559, DOI 10.1002/jbio.201100122
   Ermakov IV, 2005, J BIOMED OPT, V10, DOI 10.1117/1.2139974
   Fiedor J, 2014, NUTRIENTS, V6, P466, DOI 10.3390/nu6020466
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Han GM, 2016, NUTR RES, V36, P402, DOI 10.1016/j.nutres.2016.01.003
   Henriksen BS, 2013, INVEST OPHTH VIS SCI, V54, P5568, DOI 10.1167/iovs.13-12331
   Ishizaka N, 2007, INTERNAL MED, V46, P1167, DOI 10.2169/internalmedicine.46.0136
   Jahns L, 2014, AM J CLIN NUTR, V100, P930, DOI 10.3945/ajcn.114.086900
   Kanagasabai T, 2019, METAB SYNDR RELAT D, V17, P29, DOI 10.1089/met.2018.0080
   Krinsky Norman I., 2005, Molecular Aspects of Medicine, V26, P459
   Leermakers ETM, 2016, AM J CLIN NUTR, V103, P481, DOI 10.3945/ajcn.115.120931
   Liu J, 2014, BRIT J NUTR, V112, P2041, DOI 10.1017/S000711451400316X
   Matsumoto M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061825
   Matsuzawa Y, 2005, J ATHEROSCLER THROMB, V12, P301, DOI 10.5551/jat.12.301
   Mayne ST, 2013, ARCH BIOCHEM BIOPHYS, V539, P163, DOI 10.1016/j.abb.2013.06.007
   Nakanishi N, 2005, IND HEALTH, V43, P295, DOI 10.2486/indhealth.43.295
   Nguyen LM, 2015, ARCH BIOCHEM BIOPHYS, V572, P73, DOI 10.1016/j.abb.2015.02.015
   Obana A, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-45751-6
   Shin MJ, 2006, ANN NUTR METAB, V50, P115, DOI 10.1159/000090499
   Sluijs I, 2009, J NUTR, V139, P987, DOI 10.3945/jn.108.101451
   Sugiura M, 2008, BRIT J NUTR, V100, P1297, DOI 10.1017/S0007114508978302
   Sugiura M, 2015, BRIT J NUTR, V114, P1674, DOI 10.1017/S0007114515003268
   Suzuki K, 2011, CLIN NUTR, V30, P369, DOI 10.1016/j.clnu.2010.12.006
   Vona R, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8267234
   Wang W, 2007, AM J CLIN NUTR, V85, P762, DOI 10.1093/ajcn/85.3.762
   West CE, 1998, INT J VITAM NUTR RES, V68, P371
   Young AJ, 2001, ARCH BIOCHEM BIOPHYS, V385, P20, DOI 10.1006/abbi.2000.2149
   Zidichouski JA, 2009, J AM COLL NUTR, V28, P687, DOI 10.1080/07315724.2009.10719802
NR 43
TC 17
Z9 18
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JAN
PY 2022
VL 11
IS 1
AR 14
DI 10.3390/antiox11010014
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA ZD8EJ
UT WOS:000758428000001
PM 35052521
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gupte, SA
AF Gupte, Sachin A.
TI Targeting the Pentose Phosphate Pathway in Syndrome X-Related
   Cardiovascular Complications
SO DRUG DEVELOPMENT RESEARCH
LA English
DT Review
DE syndrome X; hyperglycemia; hyperinsulinemia; diabetes; obesity;
   hyperlipidemia; glucose-6-phosphate dehydrogenase; pentose phosphate
   pathway; reactive oxygen species
ID GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY DECREASES;
   DEHYDROGENASE-DERIVED NADPH; SMOOTH-MUSCLE-CELLS; OXIDATIVE STRESS;
   SUPEROXIDE-PRODUCTION; NAD(P)H OXIDASE; NITRIC-OXIDE;
   PHOSPHATIDYLINOSITOL 3-KINASE; VASCULAR SUPEROXIDE; THERAPEUTIC TARGET
AB Syndrome X is a combination or co-occurrence of several known cardiovascular risk factors (including central obesity, dyslipidemias, fatty liver disease, hyperinsulinemia, insulin resistance, and hypertension) that affects at least one in five people in developed countries. Syndrome X shortens life and increases morbidity by contributing to the development of both diabetes and cardiovascular disease. Type 1 or 2 diabetes affects approximately 170 million people globally, and these numbers are rapidly rising. In patients with diabetes, vascular diseases develop early and progress at an accelerated rate. It has recently become evident that glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme in the pentose-phosphate pathway and its reaction products play key roles in regulating vascular function. Epidemiological studies have also shown that G6PD deficiency markedly reduces retinopathy and mortality due to cardiovascular diseases in males from certain Mediterranean regions. Conversely, G6PD expression and activity are upregulated in rat and mouse models of obesity, hyperglycemia, and hyperinsulinemia, and a role for G6PD in the development of insulin resistance in type 2 diabetes has been proposed. Unfortunately, no selective drugs are available to validate the hypothesis that G6PD and its products are involved in the development of syndrome X in humans. This review discusses the potential mechanisms by which G6PD could be implicated in vascular diseases in syndrome X and the need to develop new approaches, including new drugs and molecular tools, to ameliorate diabetes-induced vascular dysfunction and vasculopathies. Drug Dev Res 71:161-167, 2010. (C) 2010 Wiley-Liss, Inc.
C1 [Gupte, Sachin A.] Univ S Alabama, Coll Med, Dept Biochem & Mol Biol, Mobile, AL USA.
C3 University of South Alabama
RP Gupte, SA (corresponding author), Univ S Alabama, Dept Biochem & Mol Biol, Coll Med, MSB 2312,307 Univ Blvd, N Mobile, AL 36688 USA.
EM sagutpe@usouthal.edu
FU AHA [0435070N]; NIH [RO1HL085352]; American Heart Association (AHA)
   [0435070N] Funding Source: American Heart Association (AHA)
FX Grant sponsor: AHA; Grant number: 0435070N; Grant Sponsor: NIH; Grant
   number: RO1HL085352.
CR Abraham NG, 2004, AM J PHYSIOL-HEART C, V287, pH2468, DOI 10.1152/ajpheart.01187.2003
   AKPAN JO, 1982, ACTA DIABETOL LAT, V19, P37, DOI 10.1007/BF02581184
   Aragno M, 1999, FREE RADICAL BIO MED, V26, P1467, DOI 10.1016/S0891-5849(99)00012-X
   Batetta B, 2002, CELL PROLIFERAT, V35, P143
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   CALVO JC, 1979, HORM METAB RES, V11, P161, DOI 10.1055/s-0028-1092701
   CLEARY MP, 1986, INT J OBESITY, V10, P193
   ELLWOOD KC, 1985, P SOC EXP BIOL MED, V179, P163
   GORDON GB, 1987, ADV ENZYME REGUL, V26, P355, DOI 10.1016/0065-2571(87)90023-9
   Goudar RK, 2005, AM J HEMATOL, V78, P83, DOI 10.1002/ajh.20023
   Gupte RS, 2007, J CARD FAIL, V13, P497, DOI 10.1016/j.cardfail.2007.04.003
   Gupte RS, 2009, FREE RADICAL BIO MED, V47, P219, DOI 10.1016/j.freeradbiomed.2009.01.028
   Gupte SA, 2005, AM J PHYSIOL-HEART C, V288, pH13, DOI 10.1152/ajpheart.00629.2004
   Gupte SA, 2008, CURR OPIN INVEST DR, V9, P993
   Gupte SA, 2006, J MOL CELL CARDIOL, V41, P340, DOI 10.1016/j.yjmcc.2006.05.003
   Guzik TJ, 2006, ARTERIOSCL THROM VAS, V26, P333, DOI 10.1161/01.ATV.0000196651.64776.51
   Guzik TJ, 2002, CIRCULATION, V105, P1656, DOI 10.1161/01.CIR.0000012748.58444.08
   HOTHERSALL JS, 1992, BIOCHEM INT, V27, P945
   Hu FB, 2002, DIABETES CARE, V25, P1129, DOI 10.2337/diacare.25.7.1129
   Jiang GQ, 2002, FRONT BIOSCI-LANDMRK, V7, pD904
   Kher M M, 1974, J Assoc Physicians India, V22, P601
   Leopold JA, 2000, AM J PHYSIOL-HEART C, V279, pH2477, DOI 10.1152/ajpheart.2000.279.5.H2477
   Leopold JA, 2003, ARTERIOSCL THROM VAS, V23, P411, DOI 10.1161/01.ATV.0000056744.26901.BA
   Li JM, 2004, AM J PHYSIOL-REG I, V287, pR1014, DOI 10.1152/ajpregu.00124.2004
   Matsui R, 2005, CIRCULATION, V112, P257, DOI 10.1161/CIRCULATIONAHA.104.499095
   Matsui R, 2006, ARTERIOSCL THROM VAS, V26, P910, DOI 10.1161/01.ATV.0000205850.49390.3b
   Matsuzaki Y, 2006, CURR PHARM DESIGN, V12, P3411, DOI 10.2174/138161206778194015
   McCabe TJ, 2000, J BIOL CHEM, V275, P6123, DOI 10.1074/jbc.275.9.6123
   Meininger CJ, 2000, BIOCHEM J, V349, P353, DOI 10.1042/0264-6021:3490353
   Meloni L, 2008, J INHERIT METAB DIS, V31, P412, DOI 10.1007/s10545-008-0704-5
   MUGGEO M, 1993, HORM METAB RES, V25, P160, DOI 10.1055/s-2007-1002068
   Park J, 2005, MOL CELL BIOL, V25, P5146, DOI 10.1128/MCB.25.12.5146-5157.2005
   Park J, 2006, DIABETES, V55, P2939, DOI 10.2337/db05-1570
   PEARSON TA, 1977, AM J PATHOL, V86, P657
   Reddy MA, 2006, J BIOL CHEM, V281, P13685, DOI 10.1074/jbc.M511425200
   Sasaoka T, 2006, PHARMACOL THERAPEUT, V112, P799, DOI 10.1016/j.pharmthera.2006.06.001
   Serpillon S, 2009, AM J PHYSIOL-HEART C, V297, pH153, DOI 10.1152/ajpheart.01142.2008
   SHANTZ LM, 1989, P NATL ACAD SCI USA, V86, P3852, DOI 10.1073/pnas.86.10.3852
   Shin ES, 2008, BIOORGAN MED CHEM, V16, P3580, DOI 10.1016/j.bmc.2008.02.030
   TARACH JS, 1978, ACTA HISTOCHEM, V61, P257, DOI 10.1016/S0065-1281(78)80072-5
   Toth E, 2007, AM J PHYSIOL-HEART C, V293, pH3096, DOI 10.1152/ajpheart.01335.2006
   Wagle A, 1998, J BIOL CHEM, V273, P14968, DOI 10.1074/jbc.273.24.14968
   Walcher D, 2006, CIRC RES, V99, P1181, DOI 10.1161/01.RES.0000251231.16993.88
   Wan GH, 2002, ENDOCRINE, V19, P191, DOI 10.1385/ENDO:19:2:191
   Wild S, 2004, DIABETES CARE, V27, P1047, DOI 10.2337/diacare.27.5.1047
   Xu YZ, 2005, AM J PHYSIOL-RENAL, V289, pF1040, DOI 10.1152/ajprenal.00076.2005
   Zhang YL, 2009, ARCH BIOCHEM BIOPHYS, V483, P45, DOI 10.1016/j.abb.2008.12.004
NR 47
TC 22
Z9 26
U1 1
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0272-4391
EI 1098-2299
J9 DRUG DEVELOP RES
JI Drug Dev. Res.
PD MAY
PY 2010
VL 71
IS 3
BP 161
EP 167
DI 10.1002/ddr.20359
PG 7
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 604LY
UT WOS:000278281700001
PM 20711518
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sangouni, AA
   Taghdir, M
   Mirahmadi, J
   Sepandi, M
   Parastouei, K
AF Sangouni, Abbas Ali
   Taghdir, Maryam
   Mirahmadi, Javad
   Sepandi, Mojtaba
   Parastouei, Karim
TI Effects of curcumin and/or coenzyme Q10 supplementation on metabolic
   control in subjects with metabolic syndrome: a randomized clinical trial
SO NUTRITION JOURNAL
LA English
DT Article
DE Metabolic syndrome; Curcumin; Coenzyme Q10; Lipid profile; Blood
   pressure; Body composition
ID DOUBLE-BLIND; HYPERTENSIVE PATIENTS; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; LIPID PROFILES; INFLAMMATION; ADIPOGENESIS; THERAPY; OBESITY;
   DIET
AB Background: Metabolic syndrome (MetS) as a cluster of conditions including hyperlipidemia, hypertension, hyperglycemia, insulin resistance, and abdominal obesity is linked to cardiovascular diseases and type 2 diabetes. Evidence suggested that intake of curcumin and coenzyme Q10 may have therapeutic effects in the management of MetS.
   Aims: We investigated the effects of curcumin and/or coenzyme Q10 supplementation on metabolic syndrome components including systolic blood pressure (SBP), diastolic blood pressure (DBP), waist circumference (WC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-c) and fasting plasma glucose (FPG) as primary outcomes, and total cholesterol (TC), low density lipoprotein-cholesterol (LDL-c) and body mass index (BMI) as secondary outcomes in subjects with MetS.
   Methods: In this 2 x 2 factorial, randomized, double-blinded, placebo-controlled study, 88 subjects with MetS were randomly assigned into four groups including curcumin plus placebo (CP), or coenzyme Q10 plus placebo (QP), or curcumin plus coenzyme Q10 (CQ), or double placebo (DP) for 12 weeks.
   Results: The CP group compared with the three other groups showed a significant reduction in HDL-c (P = 0.001), TG (P < 0.001), TC (P < 0.001), and LDL-c (P < 0.001). No significant differences were seen between the four groups in terms of SBP, DBP, FPG, WC, BMI and weight.
   Conclusion: Curcumin improved dyslipidemia, but had no effect on body composition, hypertension and glycemic control. Furthermore, coenzyme Q10 as well as the combination of curcumin and coenzyme Q10 showed no therapeutic effects in subjects with MetS. The trial was registered on 09/21/2018 at the Iranian clinical trials website (IRCT20180201038585N2), URL: https://www.irct.ir/trial/32518.
C1 [Sangouni, Abbas Ali; Taghdir, Maryam; Sepandi, Mojtaba; Parastouei, Karim] Baqiyatallah Univ Med Sci, Hlth Res Ctr, Life Style Inst, Tehran, Iran.
   [Sangouni, Abbas Ali] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran.
   [Mirahmadi, Javad] Baqiyatallah Univ Med Sci, Student Res Comm, Tehran, Iran.
C3 Baqiyatallah University of Medical Sciences (BMSU); Shahid Sadoughi
   University of Medical Sciences; Baqiyatallah University of Medical
   Sciences (BMSU)
RP Parastouei, K (corresponding author), Baqiyatallah Univ Med Sci, Hlth Res Ctr, Life Style Inst, Tehran, Iran.
EM parastouei@gmail.com
RI Sangouni, Abbas Ali/IUP-7744-2023; Sepandi, Mojtaba/I-8561-2014;
   Taghdir, Maryam/U-3122-2018
FU Baqiyatallah University of Medical Sciences
FX This study was supported by the Baqiyatallah University of Medical
   Sciences. This was a financial support for student thesis process
   including laboratory works, and provide kits as well as supplements.
CR Aadahl M, 2003, MED SCI SPORT EXER, V35, P1196, DOI 10.1249/01.MSS.0000074446.02192.14
   Adab Z, 2019, PHYTOTHER RES, V33, P1173, DOI 10.1002/ptr.6312
   Ahmed A, 2012, J PAK MED ASSOC, V62, P569
   Ainsworth BE, 2000, MED SCI SPORT EXER, V32, pS498, DOI 10.1097/00005768-200009001-00009
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Amin MM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0089169
   [Anonymous], 2016, ARCH DIG DISORD
   Baum L, 2007, PHARMACOL RES, V56, P509, DOI 10.1016/j.phrs.2007.09.013
   Carmona MC, 2009, INT J OBESITY, V33, P204, DOI 10.1038/ijo.2008.265
   De Sousa SMC, 2016, BEST PRACT RES CL OB, V37, P140, DOI 10.1016/j.bpobgyn.2016.01.006
   Derosa G, 2019, DRUG DES DEV THER, V13, P3647, DOI 10.2147/DDDT.S223153
   Ejaz A, 2009, J NUTR, V139, P919, DOI 10.3945/jn.108.100966
   Eriksson JG, 1999, BIOFACTORS, V9, P315, DOI 10.1002/biof.5520090229
   Farmanfarma KK, 2019, DIABETES METAB SYND, V13, P792, DOI 10.1016/j.dsx.2018.11.055
   Fiszman Marcelo, 2007, AMIA Annu Symp Proc, P249
   Gholnari T, 2018, J AM COLL NUTR, V37, P188, DOI 10.1080/07315724.2017.1386140
   Ghorbani Z, 2014, INT J ENDOCRINOL MET, V12, DOI 10.5812/ijem.18081
   Hadi A, 2019, PHARMACOL RES, V150, DOI 10.1016/j.phrs.2019.104505
   Halpern A, 2010, DIABETOL METAB SYNDR, V2, DOI 10.1186/1758-5996-2-55
   Hay E, 2019, CHEM-BIOL INTERACT, V310, DOI 10.1016/j.cbi.2019.108729
   Hewlings SJ, 2017, FOODS, V6, DOI 10.3390/foods6100092
   Hodgson JM, 2002, EUR J CLIN NUTR, V56, P1137, DOI 10.1038/sj.ejcn.1601464
   Izadi A, 2019, ARCH MED RES, V50, P1, DOI 10.1016/j.arcmed.2019.04.004
   Lee SK, 2012, CELL SIGNAL, V24, P2329, DOI 10.1016/j.cellsig.2012.07.022
   Lee YJ, 2011, J MED FOOD, V14, P386, DOI 10.1089/jmf.2010.1202
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   Na LX, 2013, MOL NUTR FOOD RES, V57, P1569, DOI 10.1002/mnfr.201200131
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Obeidat AA, 2015, PAK J MED SCI, V31, P1377, DOI 10.12669/pjms.316.7714
   Panahi Y, 2018, J CELL PHYSIOL, V233, P141, DOI 10.1002/jcp.25756
   Panahi Y, 2014, COMPLEMENT THER MED, V22, P851, DOI 10.1016/j.ctim.2014.07.006
   Parillo M, 2012, J ENDOCRINOL INVEST, V35, P629, DOI 10.3275/7909
   Pérez-Martínez P, 2017, NUTR REV, V75, P307, DOI 10.1093/nutrit/nux014
   Qin S, 2017, NUTR J, V16, DOI 10.1186/s12937-017-0293-y
   Raygan F, 2016, EUR J NUTR, V55, P2357, DOI 10.1007/s00394-015-1042-7
   Roberts CK, 2013, COMPR PHYSIOL, V3, P1, DOI 10.1002/cphy.c110062
   Saadati S, 2019, BMC GASTROENTEROL, V19, DOI 10.1186/s12876-019-1055-4
   Saghaei Mahmood, 2004, BMC Med Res Methodol, V4, P26, DOI 10.1186/1471-2288-4-26
   Santos-Parker JR, 2017, AGING-US, V9, P187, DOI 10.18632/aging.101149
   Saraf-Bank S, 2019, SAO PAULO MED J, V137, P414, DOI 10.1590/1516-3180.2018.0454120419
   Shao WJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0028784
   Sharifi-Rad J, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.01021
   Singh RB, 1999, J HUM HYPERTENS, V13, P203, DOI 10.1038/sj.jhh.1000778
   Thota RN, 2019, LIPIDS HEALTH DIS, V18, DOI 10.1186/s12944-019-0967-x
   Weisberg SP, 2008, ENDOCRINOLOGY, V149, P3549, DOI 10.1210/en.2008-0262
   Xu Z, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-08899-7
   Yadav Dhananjay, 2013, Glob J Health Sci, V5, P142, DOI 10.5539/gjhs.v5n6p142
   Young JM, 2012, AM J HYPERTENS, V25, P261, DOI 10.1038/ajh.2011.209
   Zhang PW, 2018, J CLIN LIPIDOL, V12, P417, DOI 10.1016/j.jacl.2017.12.006
   Zhang XQ, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0928-9
   Zhao JO, 2011, MOL CELL BIOCHEM, V351, P19, DOI 10.1007/s11010-010-0707-z
NR 51
TC 25
Z9 25
U1 1
U2 12
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2891
J9 NUTR J
JI Nutr. J.
PD OCT 3
PY 2022
VL 21
IS 1
AR 62
DI 10.1186/s12937-022-00816-7
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 5B5BB
UT WOS:000863583900001
PM 36192751
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Guerdjikova, AI
   Mori, N
   Casuto, LS
   McElroy, SL
AF Guerdjikova, Anna, I
   Mori, Nicole
   Casuto, Leah S.
   McElroy, Susan L.
TI Update on Binge Eating Disorder
SO MEDICAL CLINICS OF NORTH AMERICA
LA English
DT Article
DE Binge eating disorder; Female binge eating; Treatment; Gender; Sex
   differences; Eating dysregulation
ID COGNITIVE-BEHAVIORAL THERAPY; PRIMARY-CARE; GENDER-DIFFERENCES; OVARIAN
   HORMONES; WEIGHT-LOSS; METABOLIC SYNDROME; BULIMIA-NERVOSA;
   SEX-DIFFERENCES; OBESE MEN; WOMEN
AB Binge eating disorder (BED) is the most common eating disorder and an important public health problem. Lifetime prevalence of BED in the United States is 2.6%. In contrast to other eating disorders, the female to male ratio in BED is more balanced. BED co-occurs with a plethora of psychiatric disorders, most commonly mood and anxiety disorders. BED is also associated with obesity and its numerous complications. Although BED is similar in men and women in presentation and treatment outcomes, there are some key neurobiological differences that should be taken in consideration when personalizing treatment.
C1 [Guerdjikova, Anna, I; Mori, Nicole; Casuto, Leah S.; McElroy, Susan L.] Lindner Ctr Hope, 4075 Old Western Row Rd, Mason, OH 45040 USA.
   [Guerdjikova, Anna, I; Mori, Nicole; Casuto, Leah S.; McElroy, Susan L.] Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, 4075 Old Western Row Rd, Mason, OH 45040 USA.
C3 University System of Ohio; University of Cincinnati
RP Guerdjikova, AI (corresponding author), Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, Lindner Ctr Hope, 4075 Old Western Row Rd, Mason, OH 45040 USA.
EM anna.guerdjikova@lindnercenter.org
OI Hubsher, Dr Marshall/0000-0002-9775-0400; Hubsher,
   Marshall/0000-0002-7315-8947
CR Ålgars M, 2014, J PSYCHOSOM RES, V76, P19, DOI 10.1016/j.jpsychores.2013.11.011
   American Psychiatric Association, 2013, Diagnostic and Statistical Manual of Mental Disorders, P2013, DOI DOI 10.1176/APPI.BOOKS.9780890425596.744053
   [Anonymous], 2011, CAN J DIET PRACT RES
   [Anonymous], EAT WEIGHT DISORD
   Asarian L, 2013, AM J PHYSIOL-REG I, V305, pR1215, DOI 10.1152/ajpregu.00446.2012
   Barnes RD, 2011, PRIM CARE COMPANION, V13
   Barry DT, 2002, INT J EAT DISORDER, V31, P63, DOI 10.1002/eat.1112
   Berkman N., 2015, MANAGEMENT OUTCOMES
   Blomquist KK, 2012, COMPR PSYCHIAT, V53, P1021, DOI 10.1016/j.comppsych.2012.02.006
   Bulik CM, 2002, INT J EAT DISORDER, V32, P72, DOI 10.1002/eat.10072
   Crow SJ, 2004, INT J EAT DISORDER, V35, P348, DOI 10.1002/eat.10266
   Culbert KM, 2011, CURR TOP BEHAV NEURO, V6, P177, DOI 10.1007/7854_2010_80
   DREWNOWSKI A, 1992, APPETITE, V18, P207, DOI 10.1016/0195-6663(92)90198-F
   Edler C, 2007, PSYCHOL MED, V37, P131, DOI 10.1017/S0033291706008956
   FAIRBURN CG, 1994, INT J EAT DISORDER, V16, P363
   Fairburn CG, 2015, INT J EAT DISORDER, V48, P1038, DOI 10.1002/eat.22398
   Fichter MM, 2016, INT J EAT DISORDER, V49, P391, DOI 10.1002/eat.22501
   Field AE, 2012, PEDIATRICS, V130, pE289, DOI 10.1542/peds.2011-3663
   Geiker NRW, 2016, AM J CLIN NUTR, V104, P15, DOI 10.3945/ajcn.115.126565
   GORMALLY J, 1982, ADDICT BEHAV, V7, P47, DOI 10.1016/0306-4603(82)90024-7
   Grilo CM, 2009, INT J EAT DISORDER, V42, P228, DOI 10.1002/eat.20599
   Guerdjikova AI, 2007, EAT WEIGHT DISORD-ST, V12, pE19
   Guerdjikova AI, 2014, J MENS HEALTH, V11, P183, DOI 10.1089/jomh.2014.0041
   Hayes JE, 2008, PHYSIOL BEHAV, V95, P77, DOI 10.1016/j.physbeh.2008.04.023
   Hollinrake E, 2007, FERTIL STERIL, V87, P1369, DOI 10.1016/j.fertnstert.2006.11.039
   Hudson JI, 2007, BIOL PSYCHIAT, V61, P348, DOI 10.1016/j.biopsych.2006.03.040
   Hudson JI, 2010, AM J CLIN NUTR, V91, P1568, DOI 10.3945/ajcn.2010.29203
   Johnson JG, 2001, PSYCHOL MED, V31, P1455, DOI 10.1017/S0033291701004640
   Karhunen LJ, 2000, PSYCHIAT RES-NEUROIM, V99, P29, DOI 10.1016/S0925-4927(00)00053-6
   KENARDY J, 1994, DIABETES CARE, V17, P1197, DOI 10.2337/diacare.17.10.1197
   Kennedy-Dalby A, 2014, EUR J INTERN MED, V25, P922, DOI 10.1016/j.ejim.2014.10.020
   Kessler RM, 2016, NEUROSCI BIOBEHAV R, V63, P223, DOI 10.1016/j.neubiorev.2016.01.013
   Kessler RC, 2013, BIOL PSYCHIAT, V73, P904, DOI 10.1016/j.biopsych.2012.11.020
   Klump KL, 2008, PSYCHOL MED, V38, P1749, DOI 10.1017/S0033291708002997
   Klump KL, 2014, CLIN PSYCHOL SCI, V2, P545, DOI 10.1177/2167702614521794
   Klump KL, 2013, J ABNORM PSYCHOL, V122, P131, DOI 10.1037/a0029524
   Linna MS, 2014, AM J OBSTET GYNECOL, V211, DOI 10.1016/j.ajog.2014.03.067
   Marzilli E, 2018, ADOLESC HEALTH MED T, V9, P17, DOI 10.2147/AHMT.S148050
   Mazzeo Suzanne E, 2006, Eat Behav, V7, P47, DOI 10.1016/j.eatbeh.2005.05.008
   McElroy SL, 2015, CNS SPECTRUMS, V20, P546, DOI 10.1017/S1092852915000759
   Mitchell JE, 2016, INT J EAT DISORDER, V49, P319, DOI 10.1002/eat.22452
   Mitchell JE, 2015, INT J EAT DISORDER, V48, P215, DOI 10.1002/eat.22275
   Mond JM, 2010, J CLIN PSYCHOL MED S, V17, P56, DOI 10.1007/s10880-009-9180-9
   Munsch S, 2007, INT J EAT DISORDER, V40, P102, DOI 10.1002/eat.20350
   Östlund H, 2003, ANN NY ACAD SCI, V1007, P54, DOI 10.1196/annals.1286.006
   Pohle-Krauza RJ, 2008, PHYSIOL BEHAV, V93, P851, DOI 10.1016/j.physbeh.2007.11.051
   Reichborn-Kjennerud T, 2004, OBES RES, V12, P1445, DOI 10.1038/oby.2004.181
   Ricca V, 2010, APPETITE, V55, P656, DOI 10.1016/j.appet.2010.09.019
   Rosenbaum DL, 2016, WOMEN HEALTH ISS, V26, P420, DOI 10.1016/j.whi.2016.02.004
   Safer DL, 2010, BEHAV THER, V41, P106, DOI 10.1016/j.beth.2009.01.006
   Shingleton RM, 2015, J CONSULT CLIN PSYCH, V83, P382, DOI 10.1037/a0038849
   Sonneville KR, 2013, JAMA PEDIATR, V167, P149, DOI 10.1001/2013.jamapediatrics.12
   STUNKARD AJ, 1959, PSYCHIAT QUART, V33, P284, DOI 10.1007/BF01575455
   Svaldi J, 2010, APPETITE, V55, P685, DOI 10.1016/j.appet.2010.10.002
   Swanson SA, 2011, ARCH GEN PSYCHIAT, V68, P714, DOI 10.1001/archgenpsychiatry.2011.22
   Takii M, 1999, J PSYCHOSOM RES, V47, P221, DOI 10.1016/S0022-3999(99)00031-8
   Tanofsky MB, 1997, INT J EAT DISORDER, V21, P49
   Tozzi F, 2003, CNS NEUROL DISORD-DR, V2, P31, DOI 10.2174/1568007033338643
   Trace SE, 2012, INT J EAT DISORDER, V45, P695, DOI 10.1002/eat.22003
   Udo T, 2014, EAT BEHAV, V15, P182, DOI 10.1016/j.eatbeh.2014.01.003
   Udo T, 2013, GEN HOSP PSYCHIAT, V35, P587, DOI 10.1016/j.genhosppsych.2013.07.010
   Ulfvebrand S, 2015, PSYCHIAT RES, V230, P294, DOI 10.1016/j.psychres.2015.09.008
   Vocks S, 2010, INT J EAT DISORDER, V43, P205, DOI 10.1002/eat.20696
   Weygandt M, 2012, HUM BRAIN MAPP, V33, P2135, DOI 10.1002/hbm.21345
NR 64
TC 55
Z9 60
U1 2
U2 32
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0025-7125
EI 1557-9859
J9 MED CLIN N AM
JI Med. Clin. N. Am.
PD JUL
PY 2019
VL 103
IS 4
BP 669
EP +
DI 10.1016/j.mcna.2019.02.003
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA ID0HO
UT WOS:000471364800006
PM 31078199
DA 2025-06-11
ER

PT J
AU Newton, RU
   Galvao, DA
AF Newton, Robert U.
   Galvao, Daniel A.
TI Exercise medicine for prostate cancer
SO EUROPEAN REVIEW OF AGING AND PHYSICAL ACTIVITY
LA English
DT Review
DE Prostate cancer; Androgen deprivation therapy; Exercise; Resistance
   training; Aerobic training; Side effects
ID ANDROGEN DEPRIVATION THERAPY; RANDOMIZED CONTROLLED-TRIAL; BONE
   METASTASES; MEN; SUPPRESSION; RESISTANCE; MUSCLE; COMPLICATIONS;
   STATISTICS; GUIDELINES
AB Since initial reports in the mid-1980s, there has been increasing interest in the application of exercise as medicine for the prevention and management of cancer. A large number of high-quality, randomised, controlled trials with cancer survivors have confirmed both aerobic and resistance exercise to be highly beneficial for improving body composition, quality of life, mental health functional capacity and reducing risk of cancer recurrence and development of other chronic diseases. Such benefits have ultimately been realised in reduced cancer mortality between 30 and 60 % in large cohort retrospective studies. Treatments for prostate cancer are increasingly effective with quite high 5- and 10-year survival rates; however, side effects of endocrine treatments in particular impact on quality of life and increased co-morbidities for the survivor. Testosterone deprivation while highly effective for controlling prostate cancer growth results in loss of muscle and bone, increased fat mass, increased incidence of metabolic syndrome, cardiovascular disease and sudden death. Exercise has been demonstrated to be a very effective medicine for counteracting all of these treatment toxicities as well as improving mental health and quality of life. Exercise has been demonstrated to be safe and well tolerated by cancer patients. Current recommendation is to complete at least 150 min of aerobic exercise and two or more sessions of resistance training per week. More specific exercise prescription is required to address particular treatment toxicities such as bone loss or obesity. This paper is a review of key research from our group into exercise medicine for prostate cancer.
C1 [Newton, Robert U.; Galvao, Daniel A.] Edith Cowan Univ, Hlth & Wellness Inst, Joondalup, WA 6027, Australia.
C3 Edith Cowan University
RP Newton, RU (corresponding author), Edith Cowan Univ, Hlth & Wellness Inst, 270 Joondalup Dr, Joondalup, WA 6027, Australia.
EM r.newton@ecu.edu.au; d.galvao@ecu.edu.au
RI Newton, Robert/A-3466-2009; Galvao, Daniel A/A-2744-2010
OI Galvao, Daniel A/0000-0002-8209-2281
CR Ahlborg HG, 2008, BONE, V43, P556, DOI 10.1016/j.bone.2008.05.003
   Cheng S, 2002, BONE, V31, P126, DOI 10.1016/S8756-3282(02)00794-9
   Collins L, 2012, ASIAN J ANDROL, V14, P222, DOI 10.1038/aja.2011.109
   Friedenreich CM, 2010, EUR J CANCER, V46, P2593, DOI 10.1016/j.ejca.2010.07.028
   Galvao DA, 2008, PROSTATE CANCER P D, V11, P160, DOI 10.1038/sj.pcan.4500991
   Galvao D A, 2009, Prostate Cancer Prostatic Dis, V12, P198, DOI 10.1038/pcan.2008.51
   Galvao DA, 2005, J CLIN ONCOL, V23, P899, DOI 10.1200/JCO.2005.06.085
   Galvao DA, 2008, BJU INT, V102, P44, DOI 10.1111/j.1464-410X.2008.07539.x
   Galvao DA, 2006, MED SCI SPORT EXER, V38, P2045, DOI 10.1249/01.mss.0000233803.48691.8b
   Galvao DA, 2011, BMC CANCER, V11, DOI 10.1186/1471-2407-11-517
   Galvao DA, 2011, J UROLOGY, V186, P1291, DOI 10.1016/j.juro.2011.05.055
   Galvao DA, 2010, J CLIN ONCOL, V28, P340, DOI 10.1200/JCO.2009.23.2488
   Hayes SC, 2009, J SCI MED SPORT, V12, P428, DOI 10.1016/j.jsams.2009.03.002
   Jemal A, 2008, CA-CANCER J CLIN, V58, P71, DOI 10.3322/CA.2007.0010
   Keating NL, 2006, J CLIN ONCOL, V24, P4448, DOI 10.1200/JCO.2006.06.2497
   Kenfield SA, 2011, J CLIN ONCOL, V29, P726, DOI 10.1200/JCO.2010.31.5226
   Michaelson MD, 2008, CA-CANCER J CLIN, V58, P196, DOI 10.3322/CA.2008.0002
   Morote J, 2007, UROLOGY, V69, P500, DOI 10.1016/j.urology.2006.11.002
   Newton RU, 2009, BMC CANCER, V9, DOI 10.1186/1471-2407-9-210
   Newton RU, 2011, 12 AUSTR PROST CANC
   Schmitz KH, 2010, MED SCI SPORT EXER, V42, P1409, DOI 10.1249/MSS.0b013e3181e0c112
   Siegel R, 2012, CA-CANCER J CLIN, V62, P220, DOI 10.3322/caac.21149
   Spry NA, 2013, PROSTATE CANCER P D, V16, P66, DOI 10.1038/pcan.2012.33
   WINNINGHAM ML, 1986, PHYSICIAN SPORTSMED, V14, P125, DOI 10.1080/00913847.1986.11709201
NR 24
TC 9
Z9 10
U1 0
U2 31
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1813-7253
EI 1861-6909
J9 EUR REV AGING PHYS A
JI Eur. Rev. Aging Phys. Act.
PD APR
PY 2013
VL 10
IS 1
BP 41
EP 45
DI 10.1007/s11556-012-0114-4
PG 5
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 109GT
UT WOS:000316355300009
OA hybrid
DA 2025-06-11
ER

PT J
AU Hamer, M
   Batty, GD
   Kivimaki, M
AF Hamer, M.
   Batty, G. D.
   Kivimaki, M.
TI Risk of future depression in people who are obese but metabolically
   healthy: the English longitudinal study of ageing
SO MOLECULAR PSYCHIATRY
LA English
DT Article
DE depression; epidemiology; glycaemic control; inflammation; metabolic
   health; obesity
ID BODY-MASS INDEX; PSYCHOLOGICAL DISTRESS; CARDIOVASCULAR-DISEASE; WAIST
   CIRCUMFERENCE; GENERAL-POPULATION; PROSPECTIVE COHORT; MAJOR DEPRESSION;
   HEART-DISEASE; FOLLOW-UP; MEN
AB There is some evidence to suggest that obesity is a risk factor for the development of depression, although this is not a universal finding. This discordance might be ascribed to the existence of a 'healthy obese phenotype'-that is, obesity in the absence of the associated burden of cardiometabolic risk factors. We examined whether the association of obesity with depressive symptoms is dependent on the individual's metabolic health. Participants were 3851 men and women (aged 63.0 +/- 8.9 years, 45.1% men) from the English Longitudinal Study of Ageing, a prospective study of community dwelling older adults. Obesity was defined as body mass index >= 30 kgm(-2). Based on blood pressure, high-density lipoprotein cholesterol, triglycerides, glycated haemoglobin and C-reactive protein, participants were classified as 'metabolically healthy' (0 or 1 metabolic abnormality) or 'unhealthy' (>= 2 metabolic abnormalities). Depressive symptoms were assessed at baseline and at 2 years follow-up using the 8-item Centre of Epidemiological Studies Depression (CES-D) scale. Obesity prevalence was 27.5%, but 34.3% of this group was categorized as metabolically healthy at baseline. Relative to non-obese healthy participants, after adjustment for baseline CES-D score and other covariates, the metabolically unhealthy obese participants had elevated risk of depressive symptoms at follow-up (odds ratio (OR) = 1.50; 95% confidence interval (CI), 1.05-2.15), although the metabolically healthy obese did not (OR 1.38; 95% CI, 0.88-2.17). The association between obesity and risk of depressive symptoms appears to be partly dependent on metabolic health, although further work is required to confirm these findings.
C1 [Hamer, M.; Batty, G. D.; Kivimaki, M.] UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England.
C3 University of London; University College London
RP Hamer, M (corresponding author), UCL, Dept Epidemiol & Publ Hlth, 1-19 Torrington Pl, London WC1E 6BT, England.
EM m.hamer@ucl.ac.uk
RI Kivimaki, Mika/B-3607-2012; Batty, GD/Y-4401-2018; Hamer,
   Mark/C-1602-2008
OI Batty, George/0000-0003-1822-5753; Hamer, Mark/0000-0002-8726-7992;
   Kivimaki, Mika/0000-0002-4699-5627
FU National Institute on Aging in the United States [2RO1AG7644-01A1,
   2RO1AG017644]; Office for National Statistics; British Heart Foundation
   [RE/10/005/28296]; National Heart, Lung, and Blood Institute
   [R01HL036310-20A2]; National Institute on Aging [R01AG034454-01]; NIH,
   US; Academy of Finland; MRC [G0902037] Funding Source: UKRI
FX The data were made available through the UK Data Archive. The English
   Longitudinal Study of Ageing (ELSA) was developed by a team of
   researchers based at University College London, the Institute of Fiscal
   Studies and the National Centre for Social Research. The funding was
   provided by the National Institute on Aging in the United States (Grants
   2RO1AG7644-01A1 and 2RO1AG017644) and a consortium of UK government
   departments coordinated by the Office for National Statistics. MH was
   supported by the British Heart Foundation (RE/10/005/28296); GDB is a
   Wellcome Trust Career Development Fellow (WBS U.1300.00.006.00012.01);
   MK was supported by the National Heart, Lung, and Blood Institute
   (R01HL036310-20A2) and the National Institute on Aging (R01AG034454-01),
   NIH, US and the Academy of Finland. The funders had no role in the study
   design; in the collection, analysis and interpretation of data; in
   writing of the report; or in the decision to submit the paper for
   publication. The developers and funders of ELSA and the Archive do not
   bear any responsibility for the analyses or interpretations presented
   here.
CR Akbaraly TN, 2009, DIABETES CARE, V32, P499, DOI 10.2337/dc08-1358
   Almeida OP, 2009, AM J GERIAT PSYCHIAT, V17, P889, DOI 10.1097/JGP.0b013e3181b047e3
   Ärnlöv J, 2010, CIRCULATION, V121, P230, DOI 10.1161/CIRCULATIONAHA.109.887521
   Blüher M, 2010, CURR OPIN LIPIDOL, V21, P38, DOI 10.1097/MOL.0b013e3283346ccc
   Calori G, 2011, DIABETES CARE, V34, P210, DOI 10.2337/dc10-0665
   Carroll D, 2009, BIOL PSYCHIAT, V66, P91, DOI 10.1016/j.biopsych.2009.02.020
   CRISP AH, 1976, BRIT MED J, V1, P7, DOI 10.1136/bmj.1.6000.7
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Flint AJ, 2010, OBESITY, V18, P377, DOI 10.1038/oby.2009.223
   Gale CR, 2010, BIOL PSYCHIAT, V67, P189, DOI 10.1016/j.biopsych.2009.09.019
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Golden SH, 2008, JAMA-J AM MED ASSOC, V299, P2751, DOI 10.1001/jama.299.23.2751
   Graig R, 2006, HLTH SURVEY ENGLAND, V2, P34
   Hamer M, 2008, J AM COLL CARDIOL, V52, P2156, DOI 10.1016/j.jacc.2008.08.057
   Hildrum B, 2009, ACTA PSYCHIAT SCAND, V120, P14, DOI 10.1111/j.1600-0447.2008.01315.x
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Irwin M, 1999, ARCH INTERN MED, V159, P1701, DOI 10.1001/archinte.159.15.1701
   ISTVAN J, 1992, INT J OBESITY, V16, P999
   Katzmarzyk PT, 2006, DIABETES CARE, V29, P404, DOI 10.2337/diacare.29.02.06.dc05-1636
   Kilpeläinen TO, 2011, NAT GENET, V43, P753, DOI 10.1038/ng.866
   Kip KE, 2004, CIRCULATION, V109, P706, DOI 10.1161/01.CIR.0000115514.44135.A8
   Kivimäki M, 2011, AM J EPIDEMIOL, V173, P421, DOI 10.1093/aje/kwq444
   Kivimaki M, 2009, DIABETES CARE, V32, P1867, DOI 10.2337/dc09-0716
   Koenigsberg HW, 2004, J PSYCHIATR RES, V38, P503, DOI 10.1016/j.jpsychires.2004.03.006
   Kopelman PG, 2000, NATURE, V404, P635, DOI 10.1038/35007508
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178, DOI 10.4088/JCP.v69n0202
   Lawlor DA, 2011, J INTERN MED, V269, P525, DOI 10.1111/j.1365-2796.2011.02343.x
   Licht CMM, 2010, J CLIN ENDOCR METAB, V95, P2458, DOI 10.1210/jc.2009-2801
   Lindström J, 2006, LANCET, V368, P1673, DOI 10.1016/S0140-6736(06)69701-8
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Lyness JM, 1997, ARCH INTERN MED, V157, P449, DOI 10.1001/archinte.157.4.449
   Magnusson PKE, 2006, AM J EPIDEMIOL, V163, P1, DOI 10.1093/aje/kwj002
   Mancia G, 2007, J HYPERTENS, V25, P909, DOI 10.1097/HJH.0b013e328048d004
   Meigs JB, 2006, J CLIN ENDOCR METAB, V91, P2906, DOI 10.1210/jc.2006-0594
   Pulkki-Råback L, 2009, HEALTH PSYCHOL, V28, P108, DOI 10.1037/a0012646
   Rosmond R, 1998, J CLIN ENDOCR METAB, V83, P1853, DOI 10.1210/jc.83.6.1853
   Song YQ, 2007, AM J CARDIOL, V100, P1654, DOI 10.1016/j.amjcard.2007.06.073
   St-Pierre AC, 2005, CAN MED ASSOC J, V172, P1301, DOI 10.1503/cmaj.1040834
   Steffick, 2000, DOCUMENTATION AFFECT
   *UK DAT ARCH, ELSA US GUID DOC
   Vogelzangs N, 2011, J CLIN PSYCHIAT, V72, P598, DOI 10.4088/JCP.10m06559
   Whitlock G, 2009, LANCET, V373, P1083, DOI 10.1016/S0140-6736(09)60318-4
   Wildman RP, 2008, ARCH INTERN MED, V168, P1617, DOI 10.1001/archinte.168.15.1617
   Yau PL, 2010, DIABETOLOGIA, V53, P2298, DOI 10.1007/s00125-010-1857-y
   Zaninotto P, 2010, OBESITY, V18, P1981, DOI 10.1038/oby.2009.497
NR 46
TC 103
Z9 107
U1 1
U2 15
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD SEP
PY 2012
VL 17
IS 9
BP 940
EP 945
DI 10.1038/mp.2012.30
PG 6
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA 996DI
UT WOS:000308063900010
PM 22525487
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Muralidharan, A
   Klingaman, EA
   Prior, SJ
   Molinari, V
   Goldberg, RW
AF Muralidharan, Anjana
   Klingaman, Elizabeth A.
   Prior, Steven J.
   Molinari, Victor
   Goldberg, Richard W.
TI Medical and Psychosocial Barriers to Weight Management in Older Veterans
   With and Without Serious Mental Illness
SO PSYCHOLOGICAL SERVICES
LA English
DT Article
DE older adults; serious mental illness; veterans; obesity; weight
   management
ID LIFE-STYLE INTERVENTION; NURSING-HOME ADMISSION; PHYSICAL-ACTIVITY;
   HEALTH; ADULTS; OBESITY; SCHIZOPHRENIA; COMORBIDITY; PREVALENCE;
   OUTCOMES
AB Older adults with serious mental illness (SMI) are an understudied population with complex care needs and high rates of obesity/overweight. Little is known about the experiences of older adults with SMI with weight management. The present study is an observational study of veterans ages 55 and over with a body mass index in the overweight or obese range, comparing Veterans with schizophrenia or bipolar disorder (n = 9044) to their same-age peers with no mental health disorders (n = 71156), on their responses to a questionnaire assessment of medical and psychosocial factors related to weight management. Responses to the questionnaire between August, 2005 and May, 2013 were used to examine the following: demographics, clinical characteristics, medical barriers to weight management, current weight loss plan, reliability of social support, reasons for being overweight, and weight loss barriers. Physical health concerns were highly prevalent in both groups. Veterans in the SMI group endorsed more medical issues and were significantly more likely to endorse experiences that indicated that their medical conditions were poorly controlled (e.g., shortness of breath). Veterans in the SMI group were more likely to endorse many barriers to healthy eating and physical activity, across medical, psychological, social, and environmental domains. Even within a sample at medically high-risk for complications related to obesity and metabolic syndrome, older veterans with SMI and overweight/obesity experience more challenges with weight management than their same-age peers with overweight/obesity and no mental health disorders. Weight management interventions for this population should take a multifaceted approach.
C1 [Muralidharan, Anjana; Klingaman, Elizabeth A.; Goldberg, Richard W.] Vet Affairs Capitol Healthcare Network Mental Ill, Baltimore, MD USA.
   [Muralidharan, Anjana; Klingaman, Elizabeth A.] Univ Maryland, Dept Psychiat, College Pk, MD 20742 USA.
   [Prior, Steven J.] Univ Maryland, Div Gerontol & Geriatr Med, Sch Med & Vet Affairs Capitol Hlth Care Network V, College Pk, MD 20742 USA.
   [Molinari, Victor] Univ S Florida, Sch Aging Studies, Tampa, FL 33620 USA.
   [Goldberg, Richard W.] Univ Maryland, Sch Medicine, Dept Psychiat, College Pk, MD 20742 USA.
C3 University System of Maryland; University of Maryland College Park;
   University System of Maryland; University of Maryland College Park;
   State University System of Florida; University of South Florida;
   University System of Maryland; University of Maryland College Park
RP Muralidharan, A (corresponding author), Vet Affairs Capitol Hlth Care Network VISN 5 Ment, Baltimore VA Med Ctr, 10 North Greene St,Annex Suite 720, Baltimore, MD 21201 USA.
EM Anjana.Muralidharan2@va.gov
RI Prior, Steven/AAC-8232-2020; Molinari, Victor/AGX-1667-2022
OI Muralidharan, Anjana/0000-0002-9155-5524
FU Department of Veterans Affairs Office of Academic Affiliations Advanced
   Fellowship Program in Mental Illness Research and Treatment
FX This research is supported by the Department of Veterans Affairs Office
   of Academic Affiliations Advanced Fellowship Program in Mental Illness
   Research and Treatment. It is the result of work supported with
   resources and the use of facilities at the VA Capitol Health Care
   Network (VISN 5) MIRECC. This article reflects the authors' personal
   views and in no way represents the official view of the Department of
   Veterans Affairs of the U.S. Government.
CR Allison DB, 2009, AM J PREV MED, V36, P341, DOI 10.1016/j.amepre.2008.11.020
   American Psychiatric Association, 2015, PSYCHIAT SERV, V66, P1123
   Andrews AO, 2009, AM J GERIAT PSYCHIAT, V17, P697, DOI 10.1097/JGP.0b013e3181aad59d
   Bartels SJ, 2015, AM J PSYCHIAT, V172, P344, DOI 10.1176/appi.ajp.2014.14030357
   Brawley LR, 2003, AM J PREV MED, V25, P172, DOI 10.1016/S0749-3797(03)00182-X
   Cabassa LJ, 2010, PSYCHIAT SERV, V61, P774, DOI 10.1176/ps.2010.61.8.774
   Chafetz L, 2006, PSYCHIAT SERV, V57, P225, DOI 10.1176/appi.ps.57.2.225
   Chang CK, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019590
   Daumit GL, 2013, NEW ENGL J MED, V368, P1594, DOI 10.1056/NEJMoa1214530
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   Field A., 2009, Discovering statistics with SPSS, V3rd
   Gallagher R, 2008, INT J NURS PRACT, V14, P373, DOI 10.1111/j.1440-172X.2008.00709.x
   Goldberg RW, 2013, PSYCHIAT SERV, V64, P737, DOI 10.1176/appi.ps.201200314
   Green CA, 2015, AM J PSYCHIAT, V172, P71, DOI 10.1176/appi.ajp.2014.14020173
   Hendrie HC, 2014, AM J GERIAT PSYCHIAT, V22, P427, DOI 10.1016/j.jagp.2012.10.025
   Hendrie HC, 2013, AM J GERIAT PSYCHIAT, V21, P1267, DOI 10.1016/j.jagp.2013.01.056
   JANZ NK, 1984, HEALTH EDUC QUART, V11, P1, DOI 10.1177/109019818401100101
   Kahwati LC, 2011, TRANSL BEHAV MED, V1, P551, DOI 10.1007/s13142-011-0077-4
   Keck PE, 2003, J CLIN PSYCHIAT, V64, P1426, DOI 10.4088/JCP.v64n1205
   Kilbourne AM, 2005, AM J GERIAT PSYCHIAT, V13, P250, DOI 10.1176/appi.ajgp.13.3.250
   Klingaman EA, 2014, PSYCHIATR REHABIL J, V37, P270, DOI 10.1037/prj0000084
   Lawrence D, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f2539
   Leutwyler H, 2014, COMMUNITY MENT HLT J, V50, P75, DOI 10.1007/s10597-013-9613-7
   Littman AJ, 2015, GEN HOSP PSYCHIAT, V37, P7, DOI 10.1016/j.genhosppsych.2014.11.005
   McDevitt J, 2006, J NURS SCHOLARSHIP, V38, P50, DOI 10.1111/j.1547-5069.2006.00077.x
   McKibbin CL, 2006, SCHIZOPHR RES, V86, P36, DOI 10.1016/j.schres.2006.05.010
   Meesters PD, 2010, AM J GERIAT PSYCHIAT, V18, P862, DOI 10.1097/JGP.0b013e3181e446ff
   Miller EA, 2006, MED CARE, V44, P343, DOI 10.1097/01.mlr.0000204008.83633.ed
   MOREY MC, 1994, SOUTHERN MED J, V87, pS83
   Piatt EE, 2010, PSYCHIAT SERV, V61, P663, DOI 10.1176/ps.2010.61.7.663
   Shumway-Cook A, 2005, J AM GERIATR SOC, V53, P1217, DOI 10.1111/j.1532-5415.2005.53372.x
   Trivedi RB, 2015, AM J PUBLIC HEALTH, V105, P2564, DOI 10.2105/AJPH.2015.302836
   U. S. Census Bureau, 2008, US NAT POP PROJ REL
   Villareal DT, 2011, OBESITY, V19, P312, DOI 10.1038/oby.2010.110
   Wang PS, 2005, ARCH GEN PSYCHIAT, V62, P629, DOI 10.1001/archpsyc.62.6.629
   Yu W, 2003, MED CARE RES REV, V60, p146S, DOI 10.1177/1077558703257000
NR 36
TC 7
Z9 9
U1 0
U2 7
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 1541-1559
EI 1939-148X
J9 PSYCHOL SERV
JI Psychol. Serv.
PD NOV
PY 2016
VL 13
IS 4
BP 419
EP 427
DI 10.1037/ser0000088
PG 9
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA EB3EE
UT WOS:000387244600011
PM 27441416
OA hybrid
DA 2025-06-11
ER

PT J
AU Aguilera, J
   Jeon, S
   Chavez, M
   Ibarra-Mejia, G
   Ferreira-Pinto, J
   Whigham, LD
   Li, WW
AF Aguilera, Juan
   Jeon, Soyoung
   Chavez, Mayra
   Ibarra-Mejia, Gabriel
   Ferreira-Pinto, Joao
   Whigham, Leah D.
   Li, Wen-Whai
TI Short-Term Associations of Traffic-Related Air Pollution with
   Cardiorespiratory Outcomes Among Low-Income Residents from a US-Mexico
   Border Community
SO ATMOSPHERE
LA English
DT Article
DE air quality; traffic-related air pollution (TRAP); obesity; metabolic
   syndrome (MetS); respiratory disease; cardiovascular disease; Hispanics;
   border health; low income; public and environmental health
ID LUNG-FUNCTION; DIABETES-MELLITUS; EL-PASO; EXPOSURE; INFLAMMATION;
   POLLUTANTS; CHOLESTEROL; INSULIN; OBESITY; METRICS
AB Exposure to traffic-related air pollution is not merely linked to respiratory health issues but also poses significant risks to cardiovascular well-being. Individuals from lower-income communities residing in high-pollution zones are particularly vulnerable to adverse cardiorespiratory health impacts. Pollutants such as fine particulate matter (PM2.5 and PM10), nitrogen dioxide (NO2), and ozone (O3) are recognized as a leading, yet preventable, contributor to cardiorespiratory diseases. Although research has extensively explored the short-term impact of these pollutants on respiratory health, the immediate effects on cardiovascular outcomes require further study. We explored associations of traffic-related air pollutants with airway inflammation, lung function, and cardiovascular health outcomes (metabolic syndrome [MetS]) collected from a sample of low-income participants (N = 662) from a US-Mexico border county. Airway inflammation was measured using exhaled nitric oxide tests (eNO), while lung function parameters were measured by spirometry. MetS risk factors (waist circumference, blood pressure, triglycerides, HDL, and fasting blood glucose) were also measured. While spirometry measures were negatively associated with air pollutants (p < 0.05), no associations were noted for eNO. We also found positive associations in linear and logistic models between air pollutants and obesity (BMI: p < 0.04; waist: p < 0.03), fasting blood glucose (p < 0.03), and metabolic syndrome (p < 0.04). These findings reaffirm the immediate adverse effects of air pollution on respiratory function and shed light on its broader metabolic consequences. Environmental and neighborhood conditions could potentially influence the associations with obesity. At the same time, the links between fasting glucose and metabolic syndrome might indicate underlying oxidative stress and systemic inflammation.
C1 [Aguilera, Juan] UTHlth Houston, Ctr Community Hlth Impact, Sch Publ Hlth, El Paso, TX 79905 USA.
   [Jeon, Soyoung] New Mexico State Univ, Dept Econ Appl Stat & Int Business, Las Cruces, NM 88003 USA.
   [Chavez, Mayra; Li, Wen-Whai] Univ Texas El Paso, Dept Civil Engn, El Paso, TX 79968 USA.
   [Ibarra-Mejia, Gabriel] Univ Texas El Paso, Dept Publ Hlth Sci, El Paso, TX 79968 USA.
   [Ferreira-Pinto, Joao] Univ Texas El Paso, Coll Hlth Sci, El Paso, TX 79968 USA.
   [Whigham, Leah D.] Univ Texas Austin, Dept Nutr Sci, Austin, TX 78712 USA.
C3 New Mexico State University; University of Texas System; University of
   Texas El Paso; University of Texas System; University of Texas El Paso;
   University of Texas System; University of Texas El Paso; University of
   Texas System; University of Texas Austin
RP Aguilera, J (corresponding author), UTHlth Houston, Ctr Community Hlth Impact, Sch Publ Hlth, El Paso, TX 79905 USA.
EM juan.aguilera@uth.tmc.edu
RI ; Aguilera, Juan/GPT-0890-2022
OI Ibarra-Mejia, Gabriel/0000-0003-4312-6319; Aguilera,
   Juan/0000-0002-6451-0662; Jeon, Soyoung/0000-0003-3679-3615; Whigham,
   Leah/0000-0002-5376-8967
FU U.S. Department of Transportation through the Center for Advancing
   Research in Transportation Emissions, Energy, and Health (CARTEEH); 
   [69A3551747128]
FX This study was supported by grant 69A3551747128 from the U.S. Department
   of Transportation through the Center for Advancing Research in
   Transportation Emissions, Energy, and Health (CARTEEH).
CR Adam M, 2015, EUR RESPIR J, V45, P38, DOI 10.1183/09031936.00130014
   Aguilera J., 2016, Prevalence of risk factors for metabolic syndrome in uninsured Hispanic adults from low income communities in El Paso, Texas
   Aguilera J, 2021, TRANSPORT RES REC, V2675, P955, DOI 10.1177/03611981211021853
   ANDERSEN I, 1972, ATMOS ENVIRON, V6, P275, DOI 10.1016/0004-6981(72)90086-8
   Atkinson RW, 2010, EPIDEMIOLOGY, V21, P501, DOI 10.1097/EDE.0b013e3181debc88
   Barraza-Villarreal A, 2008, ENVIRON HEALTH PERSP, V116, P832, DOI 10.1289/ehp.10926
   Bell G, 2017, ARTERIOSCL THROM VAS, V37, P976, DOI 10.1161/ATVBAHA.116.308193
   Boogaard H, 2022, ENVIRON INT, V164, DOI 10.1016/j.envint.2022.107262
   Bowe B, 2018, LANCET PLANET HEALTH, V2, pE301, DOI 10.1016/s2542-5196(18)30140-2
   Cadelis G, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0091136
   Cai YY, 2016, HYPERTENSION, V68, P62, DOI 10.1161/HYPERTENSIONAHA.116.07218
   Chen ZH, 2016, DIABETES CARE, V39, P547, DOI 10.2337/dc15-1795
   Chuang KJ, 2010, J OCCUP ENVIRON MED, V52, P258, DOI 10.1097/JOM.0b013e3181ceff7a
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Clementi EA, 2019, TOXICS, V7, DOI 10.3390/toxics7010006
   Correia AW, 2013, EPIDEMIOLOGY, V24, P23, DOI 10.1097/EDE.0b013e3182770237
   de Bont J, 2022, J INTERN MED, V291, P779, DOI 10.1111/joim.13467
   Deguen S, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0131463
   DOCKERY DW, 1993, NEW ENGL J MED, V329, P1753, DOI 10.1056/NEJM199312093292401
   Eze IC, 2015, ENVIRON HEALTH PERSP, V123, P381, DOI 10.1289/ehp.1307823
   Fan H, 2021, FRONT ENV SCI-SWITZ, V9, DOI 10.3389/fenvs.2021.692440
   Holguin F, 2007, AM J RESP CRIT CARE, V176, P1236, DOI 10.1164/rccm.200611-1616OC
   Hu X, 2023, ECOTOX ENVIRON SAFE, V258, DOI 10.1016/j.ecoenv.2023.114992
   Josey KP, 2023, NEW ENGL J MED, V388, P1396, DOI 10.1056/NEJMsa2300523
   Laumbach RJ, 2012, J ALLERGY CLIN IMMUN, V129, P3, DOI 10.1016/j.jaci.2011.11.021
   Lee K, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16030371
   Li M, 2015, ATMOS ENVIRON, V117, P227, DOI 10.1016/j.atmosenv.2015.07.029
   Marchini T, 2023, FREE RADICAL BIO MED, V209, P320, DOI 10.1016/j.freeradbiomed.2023.10.396
   Mein SA, 2022, ANN AM THORAC SOC, V19, P1776, DOI 10.1513/AnnalsATS.202112-1352RL
   Meyts I, 2003, PEDIATR PULM, V36, P283, DOI 10.1002/ppul.10317
   Panis LI, 2017, ENVIRON HEALTH-GLOB, V16, DOI 10.1186/s12940-017-0271-z
   Park SK, 2010, ENVIRON HEALTH PERSP, V118, P1406, DOI 10.1289/ehp.0901778
   Paulin Laura, 2016, F1000Res, V5, DOI 10.12688/f1000research.7108.1
   Pope CA, 2006, J AIR WASTE MANAGE, V56, P709, DOI 10.1080/10473289.2006.10464485
   POPE CA, 1995, AM J RESP CRIT CARE, V151, P669, DOI 10.1164/ajrccm/151.3_Pt_1.669
   Pye HOT, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-27484-1
   Rangel A, 2022, ATMOS POLLUT RES, V13, DOI 10.1016/j.apr.2021.101304
   Raysoni AU, 2013, ATMOS ENVIRON, V80, P140, DOI 10.1016/j.atmosenv.2013.07.056
   Rice MB, 2013, AM J RESP CRIT CARE, V188, P1351, DOI 10.1164/rccm.201308-1414OC
   Rom WN, 2013, AM J RESP CELL MOL, V49, P691, DOI 10.1165/rcmb.2013-0253PS
   Rückerl R, 2011, INHAL TOXICOL, V23, P555, DOI 10.3109/08958378.2011.593587
   Scimeca Manuel, 2024, Heliyon, V10, pe38047, DOI 10.1016/j.heliyon.2024.e38047
   Thurston GD, 2017, EUR RESPIR J, V49, DOI 10.1183/13993003.00419-2016
   Trachsel S, 2008, CRIT CARE, V12, DOI 10.1186/cc7099
   Wang MZ, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15040631
   Weichenthal S, 2014, OBESITY, V22, P1580, DOI 10.1002/oby.20748
   Wolf K, 2016, DIABETES, V65, P3314, DOI 10.2337/db15-1567
   Xing YF, 2016, J THORAC DIS, V8, pE69, DOI 10.3978/j.issn.2072-1439.2016.01.19
   Zanobetti A, 2005, ENVIRON HEALTH PERSP, V113, P978, DOI 10.1289/ehp.7550
   Zanobetti A, 2007, ENVIRON HEALTH PERSP, V115, P769, DOI 10.1289/ehp.9201
   Zhou Y, 2016, SCI REP-UK, V6, DOI 10.1038/srep34947
   Zhu YT, 2022, SCI TOTAL ENVIRON, V827, DOI 10.1016/j.scitotenv.2022.154210
   Zora JE, 2013, SCI TOTAL ENVIRON, V448, P56, DOI 10.1016/j.scitotenv.2012.11.067
NR 53
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2073-4433
J9 ATMOSPHERE-BASEL
JI Atmosphere
PD FEB
PY 2025
VL 16
IS 2
AR 153
DI 10.3390/atmos16020153
PG 20
WC Environmental Sciences; Meteorology & Atmospheric Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA Y2S6E
UT WOS:001430689400001
OA gold
DA 2025-06-11
ER

PT J
AU Alcala-Diaz, JF
   Delgado-Lista, J
   Perez-Martinez, P
   Garcia-Rios, A
   Marin, C
   Quintana-Navarro, GM
   Gomez-Luna, P
   Camargo, A
   Almaden, Y
   Caballero, J
   Tinahones, FJ
   Ordovas, JM
   Perez-Jimenez, F
   Lopez-Miranda, J
AF Alcala-Diaz, Juan F.
   Delgado-Lista, Javier
   Perez-Martinez, Pablo
   Garcia-Rios, Antonio
   Marin, Carmen
   Quintana-Navarro, Gracia M.
   Gomez-Luna, Purificacion
   Camargo, Antonio
   Almaden, Yolanda
   Caballero, Javier
   Tinahones, Francisco J.
   Ordovas, Jose M.
   Perez-Jimenez, Francisco
   Lopez-Miranda, Jose
TI Hypertriglyceridemia Influences the Degree of Postprandial Lipemic
   Response in Patients with Metabolic Syndrome and Coronary Artery
   Disease: From the Cordioprev Study
SO PLOS ONE
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; NONFASTING TRIGLYCERIDES; OXIDATIVE STRESS;
   LIPID-METABOLISM; HEART-DISEASE; RISK; MEN; ATHEROSCLEROSIS;
   METAANALYSIS; DIETARY
AB Objective: To determine whether metabolic syndrome traits influence the postprandial lipemia response of coronary patients, and whether this influence depends on the number of MetS criteria.
   Materials and Methods: 1002 coronary artery disease patients from the CORDIOPREV study were submitted to an oral fat load test meal with 0.7 g fat/ kg body weight (12% saturated fatty acids, 10% polyunsaturated fatty acids, 43% monounsaturated fatty acids), 10% protein and 25% carbohydrates. Serial blood test analyzing lipid fractions were drawn at 0, 1, 2, 3 and 4 hours during the postprandial state. Total and incremental area under the curves of the different postprandial parameters were calculated following the trapezoid rule to assess the magnitude of change during the postprandial state
   Results: Postprandial lipemia response was directly related to the presence of metabolic syndrome. We found a positive association between the number of metabolic syndrome criteria and the response of postprandial plasma triglycerides (p< 0.001), area under the curve of triglycerides (p<0.001) and incremental area under the curve of triglycerides (p<0.001). However, the influence of them on postprandial triglycerides remained statistically significant only in those patients without basal hypertriglyceridemia. Interestingly, in stepwise multiple linear regression analysis with the AUC of triglycerides as the dependent variable, only fasting triglycerides, fasting glucose and waist circumference appeared as significant independent (P<0.05) contributors. The multiple lineal regression (R) was 0.77, and fasting triglycerides showed the greatest effect on AUC of triglycerides with a standardized coefficient of 0.75.
   Conclusions: Fasting triglycerides are the major contributors to the postprandial triglycerides levels. MetS influences the postprandial response of lipids in patients with coronary heart disease, particularly in non-hypertriglyceridemic patients.
C1 [Alcala-Diaz, Juan F.; Delgado-Lista, Javier; Perez-Martinez, Pablo; Garcia-Rios, Antonio; Marin, Carmen; Quintana-Navarro, Gracia M.; Gomez-Luna, Purificacion; Camargo, Antonio; Almaden, Yolanda; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Univ Cordoba, Hosp Univ Reina Sofia, Inst Maimonides Invest Biomed Cordoba IMIBIC, Unidad Lipidos & Arteriosclerosis,Dept Med, Cordoba, Spain.
   [Alcala-Diaz, Juan F.; Delgado-Lista, Javier; Perez-Martinez, Pablo; Garcia-Rios, Antonio; Marin, Carmen; Gomez-Luna, Purificacion; Camargo, Antonio; Almaden, Yolanda; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain.
   [Caballero, Javier] Hosp Univ Reina Sofia, Dept Anal Clin, Cordoba, Spain.
   [Tinahones, Francisco J.] Inst Salud Carlos III, CIBEROBN, Hosp Virgen Victoria, Malaga, Spain.
   [Ordovas, Jose M.] Tufts Univ, Nutr & Genom Lab, Jean Mayer US Dept Agr, Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
   [Ordovas, Jose M.] Inst Madrileno Estudios Avanzados Alimentac IMDEA, Madrid, Spain.
C3 Universidad de Cordoba; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III;
   United States Department of Agriculture (USDA); Tufts University
RP Lopez-Miranda, J (corresponding author), Univ Cordoba, Hosp Univ Reina Sofia, Inst Maimonides Invest Biomed Cordoba IMIBIC, Unidad Lipidos & Arteriosclerosis,Dept Med, Cordoba, Spain.
EM jlopezmir@uco.es
RI Delgado-Lista, Javier/KAM-7412-2024; Lopez-Miranda, Jose/Y-8306-2019;
   Marin Hinojosa, Carmen/AFO-1294-2022; Jimenez, Francisco/AAJ-9559-2021;
   Tejada, Silvia/L-7297-2014; Alcala-Diaz, Juan/Q-4455-2019; Tinahones,
   Francisco/AAB-2882-2020; Caballero-Villarraso, Javier/AAC-3434-2019;
   Camargo Garcia, Antonio/G-9720-2015; Ordovas, Jose/B-8727-2013; Perez
   Martinez, Pablo/AEL-6176-2022
OI Lopez-Miranda, Jose/0000-0002-8844-0718; Perez-Jimenez,
   Francisco/0000-0001-7499-7681; QUINTANA-NAVARRO, GRACIA
   MARIA/0000-0003-4413-4062; Alcala-Diaz, Juan
   Francisco/0000-0002-4572-3611; Delgado Lista, Francisco
   Javier/0000-0002-2982-2716; Caballero-Villarraso,
   Javier/0000-0003-0571-5147; Tinahones, Francisco J/0000-0001-6871-4403;
   Camargo Garcia, Antonio/0000-0002-0415-4184; Ordovas,
   Jose/0000-0002-7581-5680; Perez Martinez, Pablo/0000-0001-7716-8117;
   Perez Jimenez, Francisco/0000-0001-9808-1280
FU Fundacion Patrimonio Comunal Olivarero; Junta de Andalucia (Consejeria
   de Salud, Consejeria de Agricultura y Pesca; Consejeria de Innovacion,
   Ciencia y Empresa); Diputaciones de Jaen y Cordoba; Centro de Excelencia
   en Investigacion sobre Aceite de Oliva y Salud; Ministerio de Ciencia e
   Innovacion [AGL2009-122270, FIS PI10/01041, PI10/02412]; Ministerio de
   Economia y Competitividad [AGL2012/39615]; Consejeria de Economia;
   Proyectos de Investigacion de Excelencia; Junta de Andalucia [AGR922,
   PI0193/09]; Consejeria de Salud; Consejeria de Innovacion Ciencia y
   Empresa [CVI-7450]; ISCIII (Programa Rio-Hortega); Nicolas Monardes
   Programme; Consejeria de Salud-SAS (Junta de Andalucia);  [0118/08]; 
   [PI-0252/09];  [PI-0058/10]
FX The CORDIOPREV study is supported from Fundacion Patrimonio Comunal
   Olivarero, Junta de Andalucia (Consejeria de Salud, Consejeria de
   Agricultura y Pesca, Consejeria de Innovacion, Ciencia y Empresa),
   Diputaciones de Jaen y Cordoba, Centro de Excelencia en Investigacion
   sobre Aceite de Oliva y Salud and Ministerio de Medio Ambiente, Medio
   Rural y Marino, Gobierno de Espana Also supported in part by research
   grants from the Ministerio de Ciencia e Innovacion (AGL2009-122270 to J
   L-M, FIS PI10/01041 to P P-M, PI10/02412 to F P-J); Ministerio de
   Economia y Competitividad (AGL2012/39615 to J L-M); Consejeria de
   Economia, Innovacion y Ciencia, Proyectos de Investigacion de
   Excelencia, Junta de Andalucia (AGR922 to F P-J); Consejeria de Salud,
   Junta de Andalucia (PI0193/09 to J L-M), 0118/08 to F F-J, PI-0252/09 to
   J D-L, and PI-0058/10 to P P-M; Consejeria de Innovacion Ciencia y
   Empresa (CVI-7450 to J L-M. JF Alcala-Diaz is supported by a research
   contract of ISCIII (Programa Rio-Hortega). Y Almaden is a senior
   researcher supported by the Nicolas Monardes Programme, Consejeria de
   Salud-SAS (Junta de Andalucia). The CIBEROBN is an initiative of the
   Instituto de Salud Carlos III, Madrid, Spain. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
CR Alipour A, 2008, ATHEROSCLEROSIS SUPP, V9, P39, DOI 10.1016/j.atherosclerosissup.2008.05.007
   Alipour A, 2007, BIOCHEM SOC T, V35, P466, DOI 10.1042/BST0350466
   Bansal S, 2007, JAMA-J AM MED ASSOC, V298, P309, DOI 10.1001/jama.298.3.309
   Bravo E, 2007, BIOCHEM SOC T, V35, P459, DOI 10.1042/BST0350459
   CABEZAS MC, 1994, EUR J CLIN INVEST, V24, P669, DOI 10.1111/j.1365-2362.1994.tb01059.x
   Delgado-Lista J, 2010, ARTERIOSCL THROM VAS, V30, P1051, DOI 10.1161/ATVBAHA.109.202580
   Freiberg JJ, 2008, JAMA-J AM MED ASSOC, V300, P2142, DOI [10.1001/jama.2008.621, 10.1002/ana.22384]
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   GROOT PHE, 1991, ARTERIOSCLER THROMB, V11, P653, DOI 10.1161/01.ATV.11.3.653
   Grundy Scott M, 2006, Clin Cornerstone, V8 Suppl 1, pS21, DOI 10.1016/S1098-3597(06)80005-0
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Halkes CJM, 2001, INT J OBESITY, V25, P1767, DOI 10.1038/sj.ijo.0801831
   Jackson KG, 2012, ATHEROSCLEROSIS, V220, P237, DOI 10.1016/j.atherosclerosis.2011.09.047
   Jackson KG, 2012, ATHEROSCLEROSIS, V220, P22, DOI 10.1016/j.atherosclerosis.2011.08.012
   KARPE F, 1994, ATHEROSCLEROSIS, V106, P83, DOI 10.1016/0021-9150(94)90085-X
   Klop B, 2012, INT J VASC MED, V2012, DOI 10.1155/2012/947417
   Kolovou Genovefa D, 2005, Lipids Health Dis, V4, P21, DOI 10.1186/1476-511X-4-21
   Kolovou GD, 2006, MATURITAS, V55, P19, DOI 10.1016/j.maturitas.2006.01.002
   Lairon D, 2011, CURR VASC PHARMACOL, V9, P309, DOI 10.2174/157016111795495576
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Langsted A, 2008, CIRCULATION, V118, P2047, DOI 10.1161/CIRCULATIONAHA.108.804146
   Lopez-Miranda J, 2007, BRIT J NUTR, V98, P458, DOI 10.1017/S000711450774268X
   Lupattelli G, 2002, AM HEART J, V143, P733, DOI 10.1067/mhj.2002.120302
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Yubero-Serrano EM, 2013, EXP MOL MED, V45, DOI 10.1038/emm.2013.53
   Mente A, 2010, J AM COLL CARDIOL, V55, P2390, DOI 10.1016/j.jacc.2009.12.053
   Mihas C, 2011, CURR VASC PHARMACOL, V9, P271, DOI 10.2174/157016111795495530
   Miller M, 2003, J INVEST MED, V51, P50, DOI 10.2310/6650.2003.33544
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Nordestgaard BG, 2011, CURR VASC PHARMACOL, V9, P281
   Ntyintyane LM, 2008, QJM-INT J MED, V101, P111, DOI 10.1093/qjmed/hcm137
   O'Keefe JH, 2007, AM J CARDIOL, V100, P899, DOI 10.1016/j.amjcard.2007.03.107
   OMEARA NM, 1992, J CLIN ENDOCR METAB, V75, P465, DOI 10.1210/jc.75.2.465
   PATSCH JR, 1992, ARTERIOSCLER THROMB, V12, P1336, DOI 10.1161/01.ATV.12.11.1336
   Sattar N, 2003, CIRCULATION, V108, P414, DOI 10.1161/01.CIR.0000080897.52664.94
   Skalicky J, 2008, CLIN CHEM LAB MED, V46, P499, DOI 10.1515/CCLM.2008.096
   Teramura M, 2007, J ATHEROSCLER THROMB, V14, P172, DOI 10.5551/jat.E505
   van Oostrom AJHHM, 2003, J LIPID RES, V44, P576, DOI 10.1194/jlr.M200419-JLR200
   van Wijk JPH, 2003, METABOLISM, V52, P1043, DOI 10.1016/S0026-0495(03)00106-9
   ZILVERSMIT DB, 1979, CIRCULATION, V60, P473, DOI 10.1161/01.CIR.60.3.473
NR 40
TC 32
Z9 34
U1 0
U2 17
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 6
PY 2014
VL 9
IS 5
AR e96297
DI 10.1371/journal.pone.0096297
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AJ9KS
UT WOS:000338029800050
PM 24802225
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Depp, C
   Ojeda, VD
   Mastin, W
   Unützer, J
   Gilmer, TP
AF Depp, Colin
   Ojeda, Victoria D.
   Mastin, William
   Unuetzer, Juergen
   Gilmer, Todd P.
TI Trends in use of antipsychotics and mood stabilizers among Medicaid
   beneficiaries with bipolar disorder, 2001-2004
SO PSYCHIATRIC SERVICES
LA English
DT Article
ID METABOLIC SYNDROME; STEP-BD; CARE; SCHIZOPHRENIA; PATTERNS; COSTS
AB Objective: This study examined longitudinal trends in the use of mood stabilizers and antipsychotics for treatment of bipolar disorder in a large public mental health system and whether trends differed by age, gender, and race-ethnicity. Methods: Data were from Medicaid beneficiaries with bipolar disorder receiving services in the San Diego County public mental health system from 2001 to 2004. For each year the proportion of clients receiving any pharmacotherapy and the proportion receiving antipsychotics alone, mood stabilizers alone, or antipsychotics plus mood stabilizers were determined. Pharmacotherapy use was examined by age, gender, and race-ethnicity. Results: A total of 1,473 clients were identified who were continuously enrolled in Medicaid during the four years. Seventy-five percent received mood stabilizers or antipsychotics. Of this group, 33% received antipsychotics alone, 23% mood stabilizers alone, and 44% both antipsychotics and mood stabilizers. The percentage receiving mood stabilizers or antipsychotics increased significantly, from 71% in 2001 to 77% in 2004, primarily because of increased use among women. Use of mood stabilizers alone declined from 25% to 20%, and use of antipsychotics alone increased from 32% to 36%. African Americans and Latinos were less likely than non-Latino whites to receive mood stabilizers or antipsychotics; this pattern was stable over time. Conclusions: Antipsychotics were prescribed for a larger percentage of clients than mood stabilizers. Persons from ethnic minority groups were less likely to receive either medication type. Research is needed to examine factors affecting pharmacotherapy in bipolar disorder and mechanisms underlying racial-ethnic disparities in pharmacotherapy, including their persistence over time.
C1 [Ojeda, Victoria D.; Gilmer, Todd P.] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA.
   [Depp, Colin] Univ Calif San Diego, Sam & Rose Stein Inst Res Aging, La Jolla, CA 92093 USA.
   [Mastin, William] Calif Dept Vet Affairs, Sacramento, CA USA.
   [Unuetzer, Juergen] Univ Washington, Dept Psychiat, Seattle, WA 98195 USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of Washington; University of Washington Seattle
RP Gilmer, TP (corresponding author), Univ Calif San Diego, Dept Family & Prevent Med, 9500 Gilman Dr 0622, La Jolla, CA 92093 USA.
EM tgilmer@ucsd.edu
RI Unutzer, Jurgen/N-4048-2018; depp, colin/D-1264-2009
OI Depp, Colin/0000-0002-1841-6229; Unutzer, Jurgen/0009-0005-6585-7835
FU National Institute of Mental Health [MH-077225, P30-MH-066248]; National
   Institute on Drug Abuse [3-R01DA-019829-S1]
FX This work was supported in part by grants MH-077225 and P30-MH-066248
   from the National Institute of Mental Health and grant 3-R01DA-019829-S1
   from the National Institute on Drug Abuse. The authors gratefully
   acknowledge Adult and Older Adult Mental Health Services and the County
   of San Diego Health and Human Services Agency for access to the
   management information systems. The authors report no competing
   interests.
CR [Anonymous], 2002, PRACT GUID TREATM PA
   Baldessarini RJ, 2007, PSYCHIAT SERV, V58, P85, DOI 10.1176/appi.ps.58.1.85-a
   Basu R, 2004, BIPOLAR DISORD, V6, P314, DOI 10.1111/j.1399-5618.2004.00126.x
   Bauer MS, 2004, AM J PSYCHIAT, V161, P3, DOI 10.1176/appi.ajp.161.1.3
   Blanco C, 2002, AM J PSYCHIAT, V159, P1005, DOI 10.1176/appi.ajp.159.6.1005
   Busch AB, 2007, PSYCHIAT SERV, V58, P27, DOI 10.1176/appi.ps.58.1.27
   Calabrese Joseph R, 2004, J Clin Psychiatry, V65, P571
   Calabrese JR, 2000, J CLIN PSYCHIAT, V61, P841, DOI 10.4088/JCP.v61n1106
   Correll CU, 2007, SCHIZOPHR RES, V89, P91, DOI 10.1016/j.schres.2006.08.017
   Daumit GL, 2003, ARCH GEN PSYCHIAT, V60, P121, DOI 10.1001/archpsyc.60.2.121
   Depp CA, 2005, AM J GERIAT PSYCHIAT, V13, P290, DOI 10.1176/appi.ajgp.13.4.290
   Ghaemi SN, 2006, PSYCHIAT SERV, V57, P660, DOI 10.1176/appi.ps.57.5.660
   Gilmer TP, 2007, PSYCHIAT SERV, V58, P1007, DOI 10.1176/appi.ps.58.7.1007
   Gilmer TP, 2004, AM J PSYCHIAT, V161, P692, DOI 10.1176/appi.ajp.161.4.692
   Kilbourne AM, 2005, PSYCHIAT SERV, V56, P1549, DOI 10.1176/appi.ps.56.12.1549
   Kilbourne AM, 2006, AM J PUBLIC HEALTH, V96, P2113, DOI 10.2105/AJPH.2005.077628
   Li JM, 2002, J AFFECT DISORDERS, V71, P131, DOI 10.1016/S0165-0327(01)00394-9
   Peele PB, 2003, AM J PSYCHIAT, V160, P1286, DOI 10.1176/appi.ajp.160.7.1286
   SACHS GS, 2000, POSTGRAD MED, V108, P1
   Simon GE, 1999, PSYCHIATR SERV, V50, P1303, DOI 10.1176/ps.50.10.1303
   Simon NM, 2004, J CLIN PSYCHOPHARM, V24, P512, DOI 10.1097/01.jcp.0000138772.40515.70
   Taylor V, 2006, J CLIN PSYCHIAT, V67, P1034, DOI 10.4088/JCP.v67n0704
   Valenstein M, 2006, AM J PSYCHIAT, V163, P1219, DOI 10.1176/appi.ajp.163.7.1219
   Yatham LN, 2006, BIPOLAR DISORD, V8, P721, DOI 10.1111/j.1399-5618.2006.00432.x
NR 24
TC 37
Z9 40
U1 0
U2 5
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 1075-2730
J9 PSYCHIAT SERV
JI Psychiatr. Serv.
PD OCT
PY 2008
VL 59
IS 10
BP 1169
EP 1174
DI 10.1176/appi.ps.59.10.1169
PG 6
WC Health Policy & Services; Public, Environmental & Occupational Health;
   Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Psychiatry
GA 355IV
UT WOS:000259703500015
PM 18832503
DA 2025-06-11
ER

PT J
AU Aouira, N
   Khan, S
   Heussler, H
   Haywood, A
   Karaksha, A
   Bor, W
AF Aouira, Nisreen
   Khan, Sohil
   Heussler, Helen
   Haywood, Alison
   Karaksha, Abdullah
   Bor, William
TI Practitioners' Perspective on Metabolic Monitoring of Second-Generation
   Antipsychotics: Existing Gaps in Knowledge, Barriers to Monitoring, and
   Strategies
SO JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
LA English
DT Article
DE psychiatrists; perspective; barriers; strategies; antipsychotics; youth
ID QUALITY-OF-LIFE; HEALTH; SCHIZOPHRENIA; CARE; PSYCHIATRISTS;
   MEDICATIONS; CHILDREN; RECOMMENDATIONS; IMPLEMENTATION; PREDICTORS
AB Introduction: Prescription of second-generation antipsychotics (SGAs) in youth is rapidly increasing globally and in Australia. Lack of timely metabolic monitoring for potential adverse effects puts youth at greater risk for lifelong adverse health impact. Metabolic monitoring is recommended as best practice to prevent and/or manage SGA-induced weight gain/metabolic syndrome. The adherence to clinical guidelines remains suboptimal. It is crucial to gauge insight to challenges and strategies from the perspective of prescribers and to recommend strategies in promoting quality use of SGAs and adherence to pharmacovigilance standards.Methods: Psychiatrists participated through semistructured interviews within the community mental health clinics in the Queensland State of Australia. The interviews focused on barriers to monitoring and strategies to enhance rate of monitoring with key focus on practical strategies for future implications in community setting.Results: Ten participants completed the interviews. Barriers were specified such as lack of adequate resources to conduct monitoring, carers' disengagement in their youth's treatments, and patients' refusal to undergo blood tests. Strategies to enhance metabolic monitoring heavily relied on organizational support, provision of training, and education opportunities.Conclusions: Clinical recommendations require mental health providers to facilitate conduction of metabolic monitoring among youth prescribed SGA/s. However, they are not provided with enough support and there are challenges that prevent such care. It is crucial to understand the challenges in managing a complex and vulnerable patient cohort. This research has thrown light on these key aspects of existing gap between best practice standards and clinical practice in youth prescribed SGAs.
C1 [Aouira, Nisreen; Khan, Sohil; Haywood, Alison; Karaksha, Abdullah] Griffith Univ, Menzies Hlth Inst Queensland, Sch Pharm & Med Sci, Gold Coast, Qld, Australia.
   [Khan, Sohil; Heussler, Helen; Haywood, Alison; Bor, William] Univ Queensland, Mater Res Inst, Brisbane, Qld, Australia.
   [Khan, Sohil] Manipal Acad Higher Educ, Prasanna Inst Publ Hlth, Manipal, India.
   [Khan, Sohil] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Manipal, India.
   [Heussler, Helen; Bor, William] Childrens Hlth Queensland Hosp & Hlth Serv, South Brisbane, Qld, Australia.
   [Bor, William] Queensland Hlth, Ctr Childrens Hlth Res, Child & Youth Mental Hlth Serv, Brisbane, Qld, Australia.
   [Aouira, Nisreen] Griffith Univ, Menzies Hlth Inst Queensland, Sch Pharm & Med Sci, Gold Coast Campus, Gold Coast, Qld 4222, Australia.
C3 Menzies Health Institute Queensland; Griffith University; Griffith
   University - Gold Coast Campus; Mater Research; University of
   Queensland; Manipal Academy of Higher Education (MAHE); Manipal Academy
   of Higher Education (MAHE); Childrens Health Queensland Hospital &
   Health Service; Queensland Health; Menzies Health Institute Queensland;
   Griffith University; Griffith University - Gold Coast Campus
RP Aouira, N (corresponding author), Griffith Univ, Menzies Hlth Inst Queensland, Sch Pharm & Med Sci, Gold Coast Campus, Gold Coast, Qld 4222, Australia.
EM n.aouira@griffith.edu.au
RI Bor, William/J-2215-2015
OI Haywood, Alison/0000-0002-5354-8868; Aouira, Nisreen/0000-0001-9297-6737
CR Australian Institute of Health and Welfare, 2018, Data tables: chronic respiratory conditions mortality data
   Carlsen B, 2011, BMC MED RES METHODOL, V11, DOI 10.1186/1471-2288-11-26
   Correll CU, 2009, JAMA-J AM MED ASSOC, V302, P1765, DOI 10.1001/jama.2009.1549
   Coughlin M, 2018, INT J MENT HEALTH NU, V27, P1188, DOI 10.1111/inm.12417
   Crabb S, 2009, AUSTRALAS PSYCHIATRY, V17, P398, DOI 10.1080/10398560902980673
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P138
   DeJonckheere M, 2019, FAM MED COMMUNITY HE, V7, DOI 10.1136/fmch-2018-000057
   Dharni A, 2018, CHILD YOUTH SERV REV, V90, P8, DOI 10.1016/j.childyouth.2018.05.007
   Dieleman M., 2006, Improving health worker performance: in search of promising practices
   Dunbar L, 2010, AUSTRALAS PSYCHIATRY, V18, P322, DOI 10.3109/10398561003692571
   Glisczinski D, 2018, J TRANSFORM EDUC, V16, P175, DOI 10.1177/1541344618777367
   Grover S, 2014, J NEUROSCI RURAL PRA, V5, P374, DOI 10.4103/0976-3147.139989
   Guest G, 2006, FIELD METHOD, V18, P59, DOI 10.1177/1525822X05279903
   Guest G, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0232076
   Happell B, 2016, BMC PSYCHIATRY, V16, DOI 10.1186/s12888-016-0814-9
   Haupt DW, 2009, AM J PSYCHIAT, V166, P345, DOI 10.1176/appi.ajp.2008.08030383
   Hayes L, 2015, COMMUNITY MENT HLT J, V51, P591, DOI 10.1007/s10597-015-9848-6
   Hetrick S, 2010, AUSTRALAS PSYCHIATRY, V18, P451, DOI 10.3109/10398561003731189
   Kallio H, 2016, J ADV NURS, V72, P2954, DOI 10.1111/jan.13031
   Kalverdijk LJ, 2017, CHILD ADOL PSYCH MEN, V11, DOI 10.1186/s13034-017-0192-1
   Kisely S, 2011, AUSTRALAS PSYCHIATRY, V19, P364, DOI 10.3109/10398562.2011.562508
   Kolehmainen-Aitken Riitta-Liisa, 2004, Hum Resour Health, V2, P5, DOI 10.1186/1478-4491-2-5
   Kuipers E, 2010, J MENT HEALTH, V19, P401, DOI 10.3109/09638237.2010.510155
   Kuipers E, 2010, BRIT J PSYCHIAT, V196, P259, DOI 10.1192/bjp.bp.109.070466
   Le Quach P, 2009, EARLY INTERV PSYCHIA, V3, P66, DOI 10.1111/j.1751-7893.2008.00108.x
   Malterud K, 2016, QUAL HEALTH RES, V26, P1753, DOI 10.1177/1049732315617444
   Mangurian C, 2019, J AM BOARD FAM MED, V32, P418, DOI 10.3122/jabfm.2019.03.180176
   Mangurian C, 2013, PSYCHIAT SERV, V64, P597, DOI 10.1176/appi.ps.002542012
   Mcfarlane WR, 2016, FAM PROCESS, V55, P460, DOI 10.1111/famp.12235
   McLaren JL, 2017, PSYCHIAT SERV, V68, P958, DOI 10.1176/appi.ps.201500553
   Meyer JM, 2008, SCHIZOPHR RES, V101, P273, DOI 10.1016/j.schres.2007.12.487
   Möller-Leimkühler AM, 2012, EUR ARCH PSY CLIN N, V262, P157, DOI 10.1007/s00406-011-0215-5
   Morrato EH, 2010, ARCH PEDIAT ADOL MED, V164, P344, DOI 10.1001/archpediatrics.2010.48
   Morrison P, 2018, CONTEMP FAM THER, V40, P99, DOI 10.1007/s10591-017-9423-0
   Parameswaran SG, 2013, SCHIZOPHR RES, V143, P395, DOI 10.1016/j.schres.2012.08.031
   Pereira VC, 2022, HEALTH RES POLICY SY, V20, DOI 10.1186/s12961-022-00815-4
   Pringsheim T, 2012, PAED CHILD HEALT-CAN, V17, p22B, DOI 10.1093/pch/17.suppl_b.22B
   Rabinowitz J, 2013, SCHIZOPHR RES, V150, P339, DOI 10.1016/j.schres.2013.07.014
   Rich M, 1999, J ADOLESCENT HEALTH, V25, P371, DOI 10.1016/S1054-139X(99)00068-3
   Rodday AM, 2015, J CHILD ADOL PSYCHOP, V25, P351, DOI 10.1089/cap.2014.0156
   Ronsley R, 2011, J CAN ACAD CHILD ADO, V20, P134
   Rubin DM, 2015, JAMA PEDIATR, V169, DOI 10.1001/jamapediatrics.2015.0285
   Smith CM, 1997, J CLIN PHARMACOL, V37, P147, DOI 10.1002/j.1552-4604.1997.tb04773.x
   Stomski NJ, 2021, J MENT HEALTH, V30, P411, DOI 10.1080/09638237.2019.1581340
   Vaismoradi M, 2013, NURS HEALTH SCI, V15, P398, DOI 10.1111/nhs.12048
   Vasileiou K, 2018, BMC MED RES METHODOL, V18, DOI 10.1186/s12874-018-0594-7
   Walter G, 2008, AUSTRALAS PSYCHIATRY, V16, P253, DOI 10.1080/10398560801958549
NR 47
TC 4
Z9 5
U1 0
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1044-5463
EI 1557-8992
J9 J CHILD ADOL PSYCHOP
JI J. Child Adolesc. Psychopharmacol.
PD JUN 1
PY 2022
VL 32
IS 5
BP 296
EP 303
DI 10.1089/cap.2022.0021
EA JUN 2022
PG 8
WC Pediatrics; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Pharmacology & Pharmacy; Psychiatry
GA 2D3ME
UT WOS:000807287700001
PM 35666251
DA 2025-06-11
ER

PT J
AU Guerdjikova, AI
   Mori, N
   Casuto, LS
   McElroy, SL
AF Guerdjikova, Anna I.
   Mori, Nicole
   Casuto, Leah S.
   McElroy, Susan L.
TI Binge Eating Disorder
SO PSYCHIATRIC CLINICS OF NORTH AMERICA
LA English
DT Article
DE Binge eating disorder; Female binge eating; Treatment; Gender; Sex
   differences; Eating dysregulation
ID COGNITIVE-BEHAVIORAL THERAPY; RANDOMIZED CONTROLLED-TRIAL; PRIMARY-CARE;
   GENDER-DIFFERENCES; MENSTRUAL-CYCLE; BULIMIA-NERVOSA; WEIGHT-LOSS;
   METABOLIC SYNDROME; OVARIAN HORMONES; ADVERSE OUTCOMES
AB Binge eating disorder (BED) is the most common eating disorder and an important public health problem. Lifetime prevalence of BED in the United States is 2.6%. In contrast to other eating disorders, the female to male ratio in BED is more balanced. BED co-occurs with a plethora of psychiatric disorders, most commonly mood and anxiety disorders. BED is also associated with obesity and its numerous complications. Although BED is similar in men and women in presentation and treatment outcomes, there are some key neurobiological differences that should be taken in consideration when personalizing treatment.
C1 [Guerdjikova, Anna I.; Mori, Nicole; Casuto, Leah S.; McElroy, Susan L.] Lindner Ctr HOPE, 4075 Old Western Row Rd, Mason, OH 45040 USA.
   [Guerdjikova, Anna I.; Mori, Nicole; Casuto, Leah S.; McElroy, Susan L.] Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, 4075 Old Western Row Rd, Mason, OH 45040 USA.
C3 University System of Ohio; University of Cincinnati
RP Guerdjikova, AI (corresponding author), Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, Lindner Ctr HOPE, 4075 Old Western Row Rd, Mason, OH 45040 USA.
EM anna.guerdjikova@lindnercenter.org
FU Alkermes; Forest; Marriott Foundation; National Institute of Mental
   Health; Naurex; Orexigen Therapeutics, Inc; Shire; Sunovion; Takeda
   Pharmaceutical Company Ltd.; Johnson Johnson
FX Dr L.S. Casuto and Mrs N. Mori have no conflicts of interest to
   disclose. Dr S. L. McElroy is a consultant to or member of the
   scientific advisory boards of Bracket, F. Hoffmann-La Roche Ltd,
   MedAvante, Myriad, Naurex, Novo Nordisk, Shire, and Sunovion. She is a
   principal or coinvestigator on studies sponsored by the Alkermes,
   Forest, Marriott Foundation, National Institute of Mental Health,
   Naurex, Orexigen Therapeutics, Inc, Shire, Sunovion, and Takeda
   Pharmaceutical Company Ltd. She is also an inventor on US Patent No.
   6,323,236 B2, use of sulfamate derivatives for treating impulse control
   disorders, and along with the patent's assignee, University of
   Cincinnati, Cincinnati, Ohio, has received payments from Johnson &
   Johnson, which has exclusive rights under the patent. Dr A.I.
   Guerdjikova is employed by the University of Cincinnati College of
   Medicine and is a consultant for Bracket.
CR Ålgars M, 2014, J PSYCHOSOM RES, V76, P19, DOI 10.1016/j.jpsychores.2013.11.011
   American Psychiatric Association, 2013, Diagnostic and Statistical Manual of Mental Disorders, P2013, DOI DOI 10.1176/APPI.BOOKS.9780890425596.744053
   [Anonymous], 2011, CAN J DIET PRACT RES
   [Anonymous], EAT WEIGHT DISORD
   Asarian L, 2013, AM J PHYSIOL-REG I, V305, pR1215, DOI 10.1152/ajpregu.00446.2012
   Barnes RD, 2011, PRIM CARE COMPANION, V13
   Barry DT, 2002, INT J EAT DISORDER, V31, P63, DOI 10.1002/eat.1112
   Berkman N., 2015, MANAGEMENT OUTCOMES
   Blomquist KK, 2012, COMPR PSYCHIAT, V53, P1021, DOI 10.1016/j.comppsych.2012.02.006
   Bulik CM, 2002, INT J EAT DISORDER, V32, P72, DOI 10.1002/eat.10072
   Crow SJ, 2004, INT J EAT DISORDER, V35, P348, DOI 10.1002/eat.10266
   Culbert KM, 2011, CURR TOP BEHAV NEURO, V6, P177, DOI 10.1007/7854_2010_80
   DREWNOWSKI A, 1992, APPETITE, V18, P207, DOI 10.1016/0195-6663(92)90198-F
   Edler C, 2007, PSYCHOL MED, V37, P131, DOI 10.1017/S0033291706008956
   FAIRBURN CG, 1994, INT J EAT DISORDER, V16, P363
   Fairburn CG, 2015, INT J EAT DISORDER, V48, P1038, DOI 10.1002/eat.22398
   Fichter MM, 2016, INT J EAT DISORDER, V49, P391, DOI 10.1002/eat.22501
   Field AE, 2012, PEDIATRICS, V130, pE289, DOI 10.1542/peds.2011-3663
   Geiker NRW, 2016, AM J CLIN NUTR, V104, P15, DOI 10.3945/ajcn.115.126565
   GORMALLY J, 1982, ADDICT BEHAV, V7, P47, DOI 10.1016/0306-4603(82)90024-7
   Grilo CM, 2009, INT J EAT DISORDER, V42, P228, DOI 10.1002/eat.20599
   Guerdjikova AI, 2007, EAT WEIGHT DISORD-ST, V12, pE19
   Guerdjikova AI, 2014, J MENS HEALTH, V11, P183, DOI 10.1089/jomh.2014.0041
   Hayes JE, 2008, PHYSIOL BEHAV, V95, P77, DOI 10.1016/j.physbeh.2008.04.023
   Hollinrake E, 2007, FERTIL STERIL, V87, P1369, DOI 10.1016/j.fertnstert.2006.11.039
   Hudson JI, 2007, BIOL PSYCHIAT, V61, P348, DOI 10.1016/j.biopsych.2006.03.040
   Hudson JI, 2010, AM J CLIN NUTR, V91, P1568, DOI 10.3945/ajcn.2010.29203
   Johnson JG, 2001, PSYCHOL MED, V31, P1455, DOI 10.1017/S0033291701004640
   Karhunen LJ, 2000, PSYCHIAT RES-NEUROIM, V99, P29, DOI 10.1016/S0925-4927(00)00053-6
   KENARDY J, 1994, DIABETES CARE, V17, P1197, DOI 10.2337/diacare.17.10.1197
   Kennedy-Dalby A, 2014, EUR J INTERN MED, V25, P922, DOI 10.1016/j.ejim.2014.10.020
   Kessler RM, 2016, NEUROSCI BIOBEHAV R, V63, P223, DOI 10.1016/j.neubiorev.2016.01.013
   Kessler RC, 2013, BIOL PSYCHIAT, V73, P904, DOI 10.1016/j.biopsych.2012.11.020
   Klump KL, 2008, PSYCHOL MED, V38, P1749, DOI 10.1017/S0033291708002997
   Klump KL, 2014, CLIN PSYCHOL SCI, V2, P545, DOI 10.1177/2167702614521794
   Klump KL, 2013, J ABNORM PSYCHOL, V122, P131, DOI 10.1037/a0029524
   Linna MS, 2014, AM J OBSTET GYNECOL, V211, DOI 10.1016/j.ajog.2014.03.067
   Mazzeo Suzanne E, 2006, Eat Behav, V7, P47, DOI 10.1016/j.eatbeh.2005.05.008
   McElroy SL, 2015, CNS SPECTRUMS, V20, P546, DOI 10.1017/S1092852915000759
   Mitchell JE, 2016, INT J EAT DISORDER, V49, P319, DOI 10.1002/eat.22452
   Mitchell JE, 2015, INT J EAT DISORDER, V48, P215, DOI 10.1002/eat.22275
   Mond JM, 2010, J CLIN PSYCHOL MED S, V17, P56, DOI 10.1007/s10880-009-9180-9
   Munsch S, 2007, INT J EAT DISORDER, V40, P102, DOI 10.1002/eat.20350
   Östlund H, 2003, ANN NY ACAD SCI, V1007, P54, DOI 10.1196/annals.1286.006
   Pohle-Krauza RJ, 2008, PHYSIOL BEHAV, V93, P851, DOI 10.1016/j.physbeh.2007.11.051
   Reichborn-Kjennerud T, 2004, OBES RES, V12, P1445, DOI 10.1038/oby.2004.181
   Ricca V, 2010, APPETITE, V55, P656, DOI 10.1016/j.appet.2010.09.019
   Rosenbaum DL, 2016, WOMEN HEALTH ISS, V26, P420, DOI 10.1016/j.whi.2016.02.004
   Safer DL, 2010, BEHAV THER, V41, P106, DOI 10.1016/j.beth.2009.01.006
   Shingleton RM, 2015, J CONSULT CLIN PSYCH, V83, P382, DOI 10.1037/a0038849
   Sonneville KR, 2013, JAMA PEDIATR, V167, P149, DOI 10.1001/2013.jamapediatrics.12
   STUNKARD AJ, 1959, PSYCHIAT QUART, V33, P284, DOI 10.1007/BF01575455
   Svaldi J, 2010, APPETITE, V55, P685, DOI 10.1016/j.appet.2010.10.002
   Takii M, 1999, J PSYCHOSOM RES, V47, P221, DOI 10.1016/S0022-3999(99)00031-8
   Tanofsky MB, 1997, INT J EAT DISORDER, V21, P49
   Tozzi F, 2003, CNS NEUROL DISORD-DR, V2, P31, DOI 10.2174/1568007033338643
   Trace SE, 2012, INT J EAT DISORDER, V45, P695, DOI 10.1002/eat.22003
   Udo T, 2014, EAT BEHAV, V15, P182, DOI 10.1016/j.eatbeh.2014.01.003
   Udo T, 2013, GEN HOSP PSYCHIAT, V35, P587, DOI 10.1016/j.genhosppsych.2013.07.010
   Ulfvebrand S, 2015, PSYCHIAT RES, V230, P294, DOI 10.1016/j.psychres.2015.09.008
   Vocks S, 2010, INT J EAT DISORDER, V43, P205, DOI 10.1002/eat.20696
   Weygandt M, 2012, HUM BRAIN MAPP, V33, P2135, DOI 10.1002/hbm.21345
NR 62
TC 39
Z9 46
U1 6
U2 74
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0193-953X
EI 1558-3147
J9 PSYCHIAT CLIN N AM
JI Psychiatr. Clin. North Amer.
PD JUN
PY 2017
VL 40
IS 2
BP 255
EP +
DI 10.1016/j.psc.2017.01.003
PG 13
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA EW8PW
UT WOS:000402781600006
PM 28477651
DA 2025-06-11
ER

PT J
AU Sugawara, N
   Yasui-Furukori, N
   Sato, Y
   Saito, M
   Furukori, H
   Nakagami, T
   Kudo, S
   Kaneko, S
AF Sugawara, Norio
   Yasui-Furukori, Norio
   Sato, Yasushi
   Saito, Manabu
   Furukori, Hanako
   Nakagami, Taku
   Kudo, Shuhei
   Kaneko, Sunao
TI Body mass index and quality of life among outpatients with schizophrenia
   in Japan
SO BMC PSYCHIATRY
LA English
DT Article
DE Body mass index; Quality of life; Schizophrenia; Japan
ID WEIGHT-GAIN; PHYSICAL-ACTIVITY; METABOLIC SYNDROME; OBESITY; HEALTH;
   POPULATION; PREVALENCE; IMPACT; INTERVENTIONS; INDIVIDUALS
AB Background: Obesity is becoming more prevalent and thus growing as a public health concern in patients with schizophrenia. This investigation evaluated the relationship between body weight and the self-reported quality of life (QOL) of Japanese patients with schizophrenia.
   Methods: We recruited outpatients (n=225) aged 42.5 +/- 12.8 (mean +/- SD) years with a DSM-IV diagnosis of schizophrenia who were admitted to psychiatric hospitals. This study used a cross-sectional design. The assessments included an interview to obtain sociodemographic data, the second version of the Short Form Health Survey (SF-36v2), the 10-item version of the Drug Attitude Inventory (DAI-10), the Clinical Global Impression-Severity (CGI-S) and height and weight measurements. SF-36v2 subscores were examined for differences based on the following body mass index (BMI) categories: healthy weight (BMI < 24.9), overweight (BMI 25-29.9) and obese (BMI > 30). A multiple regression analysis was employed to assess the relationship between these BMI categories and QOL outcomes.
   Results: The overall prevalence of obesity in our sample was 16.4%. A multiple regression model revealed that age, gender, DAI-10 scores, CGI-S scores, social functioning, role emotional functioning, mental health, and Mental Composite Summary (MCS) score were significantly and positively associated with overweight status. Physical functioning, general health, role emotional functioning, mental health, and a physical composite summary (PCS) score were significantly and negatively associated with obesity.
   Conclusions: The burden of obesity is both a physical and a mental problem. An obesity intervention program for patients with schizophrenia may improve health-related QOL in patients with schizophrenia.
C1 [Sugawara, Norio; Yasui-Furukori, Norio; Sato, Yasushi; Saito, Manabu; Kudo, Shuhei; Kaneko, Sunao] Hirosaki Univ, Sch Med, Dept Neuropsychiat, Hirosaki, Aomori 036, Japan.
   [Sato, Yasushi] Hirosaki Aiseikai Hosp, Dept Psychiat, Hirosaki, Aomori, Japan.
   [Furukori, Hanako] Kuroishi Akebono Hosp, Dept Psychiat, Kuroishi, Aomori, Japan.
   [Nakagami, Taku] Odate Municipal Gen Hosp, Dept Psychiat, Odate, Japan.
C3 Hirosaki University
RP Sugawara, N (corresponding author), Hirosaki Univ, Sch Med, Dept Neuropsychiat, Hirosaki, Aomori 036, Japan.
EM nsuga3@yahoo.co.jp
FU Hirosaki Research Institute for the neurosciences
FX The authors would like to thank all coworkers for their skilful
   contributions to the data collection and management. This work was
   partly supported by a grant from Hirosaki Research Institute for the
   neurosciences.
CR Albright CL, 2008, OBESITY, V16, P1138, DOI 10.1038/oby.2008.31
   ALLEBECK P, 1989, SCHIZOPHRENIA BULL, V15, P81, DOI 10.1093/schbul/15.1.81
   Allison DB, 2003, PSYCHIAT SERV, V54, P565, DOI 10.1176/appi.ps.54.4.565
   Allison DB, 2001, J CLIN PSYCHIAT, V62, P22
   Arai H, 2006, J ATHEROSCLER THROMB, V13, P202, DOI 10.5551/jat.13.202
   Caemmerer J, 2012, SCHIZOPHR RES, V140, P159, DOI 10.1016/j.schres.2012.03.017
   Chwastiak LA, 2009, GEN HOSP PSYCHIAT, V31, P1, DOI 10.1016/j.genhosppsych.2008.09.012
   De Hert M, 2006, SCHIZOPHR RES, V88, P222, DOI 10.1016/j.schres.2006.07.025
   Dickerson FB, 2006, ACTA PSYCHIAT SCAND, V113, P306, DOI 10.1111/j.1600-0447.2005.00637.x
   Faulkner G, 2007, SCHIZOPHR RES, V90, P174, DOI 10.1016/j.schres.2006.10.009
   Faulkner G, 2007, SCHIZOPHRENIA BULL, V33, P654, DOI 10.1093/schbul/sbm022
   Fontaine K R, 2001, Obes Rev, V2, P173, DOI 10.1046/j.1467-789x.2001.00032.x
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Funahashi K, 2011, QUAL LIFE RES, V20, P199, DOI 10.1007/s11136-010-9748-8
   Gupta S, 1998, ACTA PSYCHIAT SCAND, V97, P290, DOI 10.1111/j.1600-0447.1998.tb10002.x
   Kolotkin R L, 2001, Obes Rev, V2, P219, DOI 10.1046/j.1467-789X.2001.00040.x
   Kolotkin RL, 2008, OBESITY, V16, P749, DOI 10.1038/oby.2007.133
   Leucht S, 2007, ACTA PSYCHIAT SCAND, V116, P317, DOI 10.1111/j.1600-0447.2007.01095.x
   MARTIN RL, 1985, ARCH GEN PSYCHIAT, V42, P47
   Moore DJ, 2011, J HEALTH PSYCHOL, V16, P895, DOI 10.1177/1359105310394228
   Sivalingam SK, 2011, J GEN INTERN MED, V26, P616, DOI 10.1007/s11606-010-1623-3
   Strassnig M, 2003, SCHIZOPHR RES, V62, P73, DOI 10.1016/S0920-9964(02)00441-3
   Sugawara N, 2011, ANN GEN PSYCHIATR, V10, DOI 10.1186/1744-859X-10-27
   Susce MT, 2005, J CLIN PSYCHIAT, V66, P167, DOI 10.4088/JCP.v66n0203
   Vancampfort D, 2012, ACTA PSYCHIAT SCAND, V125, P352, DOI 10.1111/j.1600-0447.2011.01814.x
   Vancampfort D, 2011, ACTA PSYCHIAT SCAND, V123, P423, DOI 10.1111/j.1600-0447.2010.01666.x
   Vancampfort D, 2012, PSYCHIAT RE IN PRESS
   Vancampfort D, 2011, SCHIZOPHR RES, V129, P122, DOI 10.1016/j.schres.2011.03.018
   Weiden PJ, 2004, SCHIZOPHR RES, V66, P51, DOI 10.1016/S0920-9964(02)00498-X
NR 29
TC 21
Z9 22
U1 0
U2 8
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD APR 9
PY 2013
VL 13
AR 108
DI 10.1186/1471-244X-13-108
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 141BG
UT WOS:000318699700001
PM 23570345
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU McMahen, C
   Wright, K
   Stanton, R
   Lederman, O
   Rosenbaum, S
   McKeon, G
   Furzer, B
AF McMahen, Caleb
   Wright, Kemi
   Stanton, Robert
   Lederman, Oscar
   Rosenbaum, Simon
   McKeon, Grace
   Furzer, Bonnie
TI Outcome assessments used in studies examining the effect of prescribed
   exercise interventions for people living with severe mental illness, a
   scoping review
SO MENTAL HEALTH AND PHYSICAL ACTIVITY
LA English
DT Review
DE Severe mental illness; Exercise; Assessment; Physical health; Mental
   health
ID MAJOR DEPRESSIVE DISORDER; WEIGHT-LOSS INTERVENTION; QUALITY-OF-LIFE;
   METABOLIC SYNDROME; PHYSICAL-ACTIVITY; PSYCHOTIC DISORDERS; AEROBIC
   EXERCISE; CARDIORESPIRATORY FITNESS; WAIST CIRCUMFERENCE; HEALTH
AB Background: Exercise interventions are increasingly incorporated in the management of severe mental illness; however, best practice screening and outcome monitoring for this unique population are yet to be established. This review aims to explore assessment measures reported in publications of exercise interventions in severe mental illness.
   Methods: A scoping review was implemented with a structured search of Embase, PubMed, Medline, PsychINFO, Scopus, and SportDiscus using terms related to severe mental illness, exercise, and health. Studies were included if they incorporated an exercise intervention for people with severe mental illness and measured physical and/or mental health outcomes. Studies were analysed for population, assessment measures, and methodological quality.
   Results: 1832 studies were identified and following screening and full text review 38 studies involving 2854 participants were included for analysis, primarily psychotic (n = 13), depressive disorder (n = 9) and mixed severe mental illness populations (n = 13). The most frequently reported health domains and assessment measures used included body composition (weight and body mass index), symptom severity, cardiorespiratory fitness (volume of oxygen consumption), cardiometabolic health (blood pressure and metabolic blood sampling), and quality of life. Methodological quality varied with 13 determined as good, 12 fair, and 13 poor.
   Conclusion: The review identified domains and assessment tools frequently reported in the exercise and severe mental illness literature. However, given the heterogeneity and scarcity of the research, along with lack of reporting of sufficient detail, best-practice clinical recommendations are still limited. There remains a need to establish best practice assessment and monitoring procedures within exercise interventions in severe mental illness.
C1 [McMahen, Caleb; Wright, Kemi; Furzer, Bonnie] Univ Western Australia, Sch Human Sci Exercise & Sport Sci, Nedlands, WA, Australia.
   [Wright, Kemi; Furzer, Bonnie] South Metropolitan Hlth Serv, Fremantle Hosp Mental Hlth Serv, Perth, WA, Australia.
   [Stanton, Robert] Appleton Inst, Cluster Resilience & Wellbeing, Wayville, SA, Australia.
   [Stanton, Robert] Cent Queensland Univ, Sch Hlth Med & Appl Sci, Rockhampton, Qld, Australia.
   [Lederman, Oscar] South Eastern Sydney Local Hlth Dist, Keeping Body Mind Program, Sydney, NSW, Australia.
   [Lederman, Oscar] Univ New South Wales Sydney, Sch Hlth Sci, Sydney, NSW, Australia.
   [Rosenbaum, Simon; McKeon, Grace] Univ New South Wales Sydney, Sch Psychiat, Sydney, NSW, Australia.
   [Rosenbaum, Simon; McKeon, Grace] Prince Wales Hosp, Black Dog Inst, Sydney, NSW, Australia.
C3 University of Western Australia; South Metropolitan Health Service;
   Central Queensland University; South Eastern Sydney Local Health
   District; University of New South Wales Sydney; University of New South
   Wales Sydney; Black Dog Institute; University of New South Wales Sydney;
   Prince of Wales Hospital (POWH)
RP Furzer, B (corresponding author), Univ Western Australia, Sch Human Sci M408, 35 Stirling Highway, Crawley 6009, Australia.
EM bonnie.furzer@uwa.edu.au
RI McMahen, Caleb/MVU-6248-2025; Wright, Kemi/ABF-8504-2020; Furzer,
   Bonnie/ABE-6541-2020; McKeon, Grace/ADI-3804-2022; Stanton,
   Rob/AAJ-5157-2020; Rosenbaum, Simon/Y-3241-2019
OI Lederman, Oscar/0000-0002-0321-5723; Furzer, Bonnie/0000-0002-0321-6988;
   McMahen, Caleb/0000-0001-6061-3886; Rosenbaum,
   Simon/0000-0002-8984-4941; McKeon, Grace/0000-0003-4722-1639
CR Abdel-Baki A, 2013, SCHIZOPHR RES, V149, P112, DOI 10.1016/j.schres.2013.06.040
   Acil AA, 2008, J PSYCHIATR MENT HLT, V15, P808, DOI 10.1111/j.1365-2850.2008.01317.x
   [Anonymous], 2020, Covidence Systematic Review Software version 5.3
   Arksey H., 2005, INT J SOC RES METHOD, V8, P19, DOI [DOI 10.1080/1364557032000119616, 10.1080/1364557032000119616]
   Ashdown-Franks G, 2019, J AFFECT DISORDERS, V243, P448, DOI 10.1016/j.jad.2018.09.036
   Association AP, 2013, Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
   Baar K, 2006, ESSAYS BIOCHEM, V42, P61, DOI 10.1042/bse0420061
   Babwah Terence, 2018, J Family Med Prim Care, V7, P1446, DOI 10.4103/jfmpc.jfmpc_84_18
   Ball MP, 2001, PSYCHIATR SERV, V52, P967, DOI 10.1176/appi.ps.52.7.967
   Bartels SJ, 2018, PSYCHIAT SERV, V69, P664, DOI 10.1176/appi.ps.201700368
   Bartels SJ, 2015, AM J PSYCHIAT, V172, P344, DOI 10.1176/appi.ajp.2014.14030357
   Bartels SJ, 2013, PSYCHIAT SERV, V64, P729, DOI 10.1176/appi.ps.003622012
   Beebe Lora Humphrey, 2005, Issues Ment Health Nurs, V26, P661
   Bernard P, 2015, DISABIL REHABIL, V37, P921, DOI 10.3109/09638288.2014.948136
   Bigaard J, 2003, OBES RES, V11, P895, DOI 10.1038/oby.2003.123
   Blouin M, 2009, CAN J PSYCHIAT, V54, P275, DOI 10.1177/070674370905400409
   Blumenthal JA, 1999, ARCH INTERN MED, V159, P2349, DOI 10.1001/archinte.159.19.2349
   Brill PA, 2000, MED SCI SPORT EXER, V32, P412, DOI 10.1097/00005768-200002000-00023
   Brown RA, 2007, J NERV MENT DIS, V195, P514, DOI 10.1097/01.nmd.0000253730.31610.6c
   Carrà G, 2014, SOC PSYCH PSYCH EPID, V49, P1739, DOI 10.1007/s00127-014-0835-y
   Chang CK, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019590
   Chino B, 2009, PSYCHIAT CLIN NEUROS, V63, P521, DOI 10.1111/j.1440-1819.2009.01995.x
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   Correll Christoph U, 2010, Psychiatr Serv, V61, P892, DOI 10.1176/ps.2010.61.9.892
   Curtis J, 2016, EARLY INTERV PSYCHIA, V10, P267, DOI 10.1111/eip.12230
   Daudt HML, 2013, BMC MED RES METHODOL, V13, DOI 10.1186/1471-2288-13-48
   Daumit GL, 2011, INT J OBESITY, V35, P1114, DOI 10.1038/ijo.2010.224
   Daumit GL, 2013, NEW ENGL J MED, V368, P1594, DOI 10.1056/NEJMoa1214530
   de la Cerda P, 2011, PERCEPT MOTOR SKILL, V112, P761, DOI 10.2466/02.15.PMS.112.3.761-769
   Dickerson F., 2019, SCHIZOPHRENIA BULL, V45, DOI [10.1093/schbul/sbz022.018.S95-S95, DOI 10.1093/SCHBUL/SBZ022.018.S95-S95]
   Dixon L, 2001, J NERV MENT DIS, V189, P17, DOI 10.1097/00005053-200101000-00004
   Dodd KJ, 2011, DISABIL REHABIL, V33, P1222, DOI 10.3109/09638288.2010.526162
   Dunn AL, 2005, AM J PREV MED, V28, P1, DOI 10.1016/j.amepre.2004.09.003
   Duraiswamy G, 2007, ACTA PSYCHIAT SCAND, V116, P226, DOI 10.1111/j.1600-0447.2007.01032.x
   Eldridge SM, 2016, BMJ-BRIT MED J, V355, DOI 10.1136/bmj.i5239
   Firth J, 2016, PSYCHOL MED, V46, P2869, DOI 10.1017/S0033291716001732
   Firth J, 2015, PSYCHOL MED, V45, P1343, DOI 10.1017/S0033291714003110
   Firth J, 2019, LANCET PSYCHIAT, V6, P675, DOI 10.1016/S2215-0366(19)30132-4
   Firth J, 2018, SCHIZOPHRENIA BULL, V44, P728, DOI 10.1093/schbul/sby034
   Fleig L, 2014, PSYCHOL HEALTH, V29, P1361, DOI 10.1080/08870446.2014.930146
   Gerber M, 2019, J PSYCHIATR RES, V113, P58, DOI 10.1016/j.jpsychires.2019.03.011
   Gfroerer J, 2013, MMWR-MORBID MORTAL W, V62, P81
   Giannopoulou I, 2014, EUR J SPORT SCI, V14, P620, DOI 10.1080/17461391.2013.862871
   Goldstein LA, 2018, J AFFECT DISORDERS, V227, P345, DOI 10.1016/j.jad.2017.11.002
   Hagberg LA, 2009, SCAND J MED SCI SPOR, V19, P740, DOI 10.1111/j.1600-0838.2008.00844.x
   Harber MP, 2017, PROG CARDIOVASC DIS, V60, P11, DOI 10.1016/j.pcad.2017.03.001
   Heggelund J, 2011, NORD J PSYCHIAT, V65, P269, DOI 10.3109/08039488.2011.560278
   Hoffman BM, 2008, MED SCI SPORT EXER, V40, P1344, DOI 10.1249/MSS.0b013e31816b877c
   John AP, 2009, MED J AUSTRALIA, V190, P176, DOI 10.5694/j.1326-5377.2009.tb02342.x
   Kerling A, 2015, J AFFECT DISORDERS, V177, P1, DOI 10.1016/j.jad.2015.01.006
   Kredlow MA, 2015, J BEHAV MED, V38, P427, DOI 10.1007/s10865-015-9617-6
   Krogh J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048316
   Krogh J, 2009, J CLIN PSYCHIAT, V70, P790, DOI 10.4088/JCP.08m04241
   Laferrier JZ, 2015, AM J PHYS MED REHAB, V94, P1026, DOI 10.1097/PHM.0000000000000263
   Lambert JD, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4778-6
   Lawrence D, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f2539
   LeBouthillier DM, 2017, J ANXIETY DISORD, V52, P43, DOI 10.1016/j.janxdis.2017.09.005
   Lederman O, 2019, J PSYCHIATR RES, V109, P96, DOI 10.1016/j.jpsychires.2018.11.004
   Lederman O, 2016, AUSTRALAS PSYCHIATRY, V24, P347, DOI 10.1177/1039856216632400
   Levac D, 2010, IMPLEMENT SCI, V5, DOI 10.1186/1748-5908-5-69
   Licht CMM, 2009, HYPERTENSION, V53, P631, DOI 10.1161/HYPERTENSIONAHA.108.126698
   MARTINSEN EW, 1989, COMPR PSYCHIAT, V30, P324, DOI 10.1016/0010-440X(89)90057-6
   Marzolini S., 2009, MENT HEALTH PHYS ACT, V2, P29, DOI 10.1016/j.mhpa.2008.11.001
   Mayo MJ, 2003, MED SCI SPORT EXER, V35, P207, DOI 10.1249/01.MSS.0000048636.46744.01
   McNary SW, 1997, PSYCHOL ASSESSMENT, V9, P503
   Melamed Y, 2008, PSYCHIATR REHABIL J, V31, P194, DOI 10.2975/31.3.2008.194.200
   Minghetti A, 2018, PSYCHIAT RES, V265, P292, DOI 10.1016/j.psychres.2018.04.053
   Montero D, 2015, J PHYSIOL-LONDON, V593, P4677, DOI 10.1113/JP270250
   National Institutes of Health, 2014, STUD QUAL ASS TOOLS
   Oeland AM, 2010, NORD J PSYCHIAT, V64, P210, DOI 10.3109/08039480903511373
   Osborn DPJ, 2007, SOC PSYCH PSYCH EPID, V42, P787, DOI 10.1007/s00127-007-0247-3
   Osborn DPJ, 2007, ARCH GEN PSYCHIAT, V64, P242, DOI 10.1001/archpsyc.64.2.242
   Parabiaghi A, 2006, SOC PSYCH PSYCH EPID, V41, P457, DOI 10.1007/s00127-006-0048-0
   Pelletier JF, 2015, INT J EQUITY HEALTH, V14, DOI 10.1186/s12939-015-0200-0
   Pham MT, 2014, RES SYNTH METHODS, V5, P371, DOI 10.1002/jrsm.1123
   Poulin MJ, 2007, AUST NZ J PSYCHIAT, V41, P980, DOI 10.1080/00048670701689428
   Raynor AJ, 2020, J AGING PHYS ACTIV, V28, P104, DOI 10.1123/japa.2019-0088
   Riccardi G, 2000, BRIT J NUTR, V83, pS143
   Romain AJ, 2019, SCHIZOPHR RES, V210, P278, DOI 10.1016/j.schres.2018.12.021
   Rosenbaum S, 2015, ACTA PSYCHIAT SCAND, V131, P350, DOI 10.1111/acps.12371
   Rosenbaum S, 2016, AUSTRALAS PSYCHIATRY, V24, P49, DOI 10.1177/1039856215590252
   Ross R, 2000, ANN INTERN MED, V133, P92, DOI 10.7326/0003-4819-133-2-200007180-00008
   Shiers DE, 2014, Positive cardiometabolic health resource: an intervention framework for patients with psychosis and schizophrenia
   Skrinar GS, 2005, PSYCHIATR REHABIL J, V29, P122, DOI 10.2975/29.2005.122.127
   Slade T, 2009, AUST NZ J PSYCHIAT, V43, P594, DOI 10.1080/00048670902970882
   Soysal P, 2021, J SPORT HEALTH SCI, V10, P290, DOI 10.1016/j.jshs.2020.06.009
   Staiano AE, 2012, INT J OBESITY, V36, P1450, DOI 10.1038/ijo.2011.268
   Stokes J., 1989, HYPERTENSION DALLAS, V13, DOI [10.1161/01.HYP.13.5_Suppl.I13.I-13-I-18, DOI 10.1161/01.HYP.13.5_SUPPL.I13.I-13-I-18]
   Strassnig MT, 2015, PSYCHIAT RES, V229, P295, DOI 10.1016/j.psychres.2015.07.007
   Stubbs B, 2018, EUR PSYCHIAT, V54, P124, DOI 10.1016/j.eurpsy.2018.07.004
   Tricco AC, 2018, ANN INTERN MED, V169, P467, DOI 10.7326/M18-0850
   Usher K, 2013, J ADV NURS, V69, P1539, DOI 10.1111/jan.12012
   Vancampfort D, 2017, SPORTS MED, V47, P343, DOI 10.1007/s40279-016-0574-1
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   World Health Organization, 2019, ICD 10 CLASS MENT BE
   Wu MK, 2007, PSYCHIAT SERV, V58, P544, DOI 10.1176/appi.ps.58.4.544
   Zhang HQ, 2018, NUTRIENTS, V10, DOI 10.3390/nu10030364
NR 97
TC 3
Z9 3
U1 2
U2 8
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1755-2966
EI 1878-0199
J9 MENT HEALTH PHYS ACT
JI Ment. Health Phys. Act.
PD MAR
PY 2022
VL 22
AR 100438
DI 10.1016/j.mhpa.2021.100438
EA JAN 2022
PG 13
WC Psychology, Clinical; Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 0Y1NS
UT WOS:000790163100006
DA 2025-06-11
ER

PT J
AU Roberts, T
   Gureje, O
   Thara, R
   Hutchinson, G
   Cohen, A
   Weiss, HA
   John, S
   Pow, JL
   Donald, C
   Olley, B
   Esponda, GM
   Murray, RM
   Morgan, C
AF Roberts, Tessa
   Gureje, Oye
   Thara, Rangaswamy
   Hutchinson, Gerard
   Cohen, Alex
   Weiss, Helen Anne
   John, Sujit
   Pow, Joni Lee
   Donald, Casswina
   Olley, Bola
   Esponda, Georgina Miguel
   Murray, Robin M.
   Morgan, Craig
TI INTREPID II: protocol for a multistudy programme of research on
   untreated psychosis in India, Nigeria and Trinidad
SO BMJ OPEN
LA English
DT Article
ID AUSTRALIAN NATIONAL-SURVEY; GLOBAL MENTAL-HEALTH; METABOLIC SYNDROME;
   CHILDHOOD TRAUMA; RISK-FACTORS; 1ST EPISODE; PSYCHOMETRIC PROPERTIES;
   1ST-EPISODE PSYCHOSIS; SYMPTOM DIMENSIONS; LIFE EXPECTANCY
AB Introduction There are few robust and directly comparable studies of the epidemiology of psychotic disorders in the Global South. INTREPID II is designed to investigate variations in untreated psychotic disorders in the Global South in (1) incidence and presentation (2) 2-year course and outcome, (3) help-seeking and impact, and (4) physical health.
   Methods INTREPID II is a programme of research incorporating incidence, case-control and cohort studies of psychoses in contiguous urban and rural areas in India, Nigeria and Trinidad. In each country, the target samples are 240 untreated cases with a psychotic disorder, 240 age-matched, sex-matched and neighbourhood-matched controls, and 240 relatives or caregivers. Participants will be followed, in the first instance, for 2 years. In each setting, we have developed and are employing comprehensive case-finding methods to ensure cohorts are representative of the target populations. Using methods developed during pilot work, extensive data are being collected at baseline and 2-year follow-up across several domains: clinical, social, help-seeking and impact, and biological.
   Ethics and dissemination Informed consent is sought, and participants are free to withdraw from the study at any time. Participants are referred to mental health services if not already in contact with these and emergency treatment arranged where necessary. All data collected are confidential, except when a participant presents a serious risk to either themselves or others. This programme has been approved by ethical review boards at all participating centres. Findings will be disseminated through international conferences, publications in international journals, and through local events for key stakeholders.
C1 [Roberts, Tessa; Esponda, Georgina Miguel; Morgan, Craig] Inst Psychiat Psychol & Neurosci, Hlth Serv Populat Res Dept, London, England.
   [Roberts, Tessa; Esponda, Georgina Miguel; Morgan, Craig] Kings Coll London, ESRC Ctr Soc & Mental Hlth, London, England.
   [Gureje, Oye] Univ Ibadan, Dept Psychiat, WHO Collaborating Ctr Res & Training Mental Hlth, Neurosci & Subst Abuse, Ibadan, Nigeria.
   [Thara, Rangaswamy] Schizophrenia Res Fdn, Chennai, Tamil Nadu, India.
   [Hutchinson, Gerard; Pow, Joni Lee; Donald, Casswina] Univ West Indies, St Augustine Fac Med Sci, Dept Psychiat, Tunapuna Piarco, Trinidad Tobago.
   [Cohen, Alex] Harvard Univ, Dept Epidemiol, TH Chan Sch Publ Hlth, Boston, MA USA.
   [Weiss, Helen Anne] London Sch Hyg & Trop Med, Epidemiol & Populat Hlth, London, England.
   [Weiss, Helen Anne] London Sch Hyg & Trop Med, London, England.
   [Olley, Bola] Univ Ibadan, Dept Psychiat, Coll Med, Ibadan, Nigeria.
   [Murray, Robin M.] Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England.
C3 University of London; King's College London; UK Research & Innovation
   (UKRI); Economic & Social Research Council (ESRC); University of Ibadan;
   University West Indies Mona Jamaica; University West Indies Saint
   Augustine; Harvard University; Harvard T.H. Chan School of Public
   Health; University of London; London School of Hygiene & Tropical
   Medicine; University of London; London School of Hygiene & Tropical
   Medicine; University of Ibadan
RP Morgan, C (corresponding author), Inst Psychiat Psychol & Neurosci, Hlth Serv Populat Res Dept, London, England.; Morgan, C (corresponding author), Kings Coll London, ESRC Ctr Soc & Mental Hlth, London, England.
EM craig.morgan@kcl.ac.uk
RI Rangaswamy, Thara/JXK-9468-2024; weiss, helen/ABC-7823-2021; Gureje,
   Oye/J-1183-2014; murray, robin/F-8658-2012; Morgan, Craig/B-2100-2010
OI murray, robin/0000-0003-0829-0519; Rangaswamy,
   Thara/0000-0001-6813-066X; Morgan, Craig/0000-0002-1386-2369; Weiss,
   Helen/0000-0003-3547-7936; Miguel Esponda, Georgina/0000-0001-5616-191X;
   Gureje, Oye/0000-0003-0094-5947; John, Sujit/0000-0001-7157-3533
FU UK Medical Research Council (MRC) [MR/PO25927/1]; National Institute for
   Health Research (NIHR) Specialist Biomedical Research Centre for Mental
   Health at South London and Maudsley NHS Foundation Trust and King's
   College London; ESRC Centre for Society and Mental Health at King's
   College London [ES/S012567/1]; Wellcome Trust [WT094525]
FX This programme is funded by the UK Medical Research Council (MRC) (MRC
   Reference: MR/PO25927/1). The authors acknowledge financial support from
   the National Institute for Health Research (NIHR) Specialist Biomedical
   Research Centre for Mental Health at South London and Maudsley NHS
   Foundation Trust and King's College London, and the ESRC Centre for
   Society and Mental Health at King's College London (ESRC Reference:
   ES/S012567/1). This programme builds on research funded by the Wellcome
   Trust (WT094525).
CR Allardyce J, 2007, SOC PSYCH PSYCH EPID, V42, P429, DOI 10.1007/s00127-007-0179-y
   Alvarez-Jimenez M, 2012, SCHIZOPHR RES, V139, P116, DOI 10.1016/j.schres.2012.05.007
   [Anonymous], Schedule Assessment
   Asher L, 2018, CURR OPIN PSYCHIATR, V31, P193, DOI 10.1097/YCO.0000000000000404
   Awad AG, 2008, PHARMACOECONOMICS, V26, P149, DOI 10.2165/00019053-200826020-00005
   Azevedo M, 2008, INT J DIABETES DEV C, V28, P101, DOI 10.4103/0973-3930.45268
   BEBBINGTON P, 1995, INT J METHOD PSYCH, V5, P11
   Bentall RP, 2014, SOC PSYCH PSYCH EPID, V49, P1011, DOI 10.1007/s00127-014-0914-0
   Berg AO, 2014, SOC PSYCH PSYCH EPID, V49, P1747, DOI 10.1007/s00127-014-0897-x
   Bonita R, 2003, GLOBAL BEHAVIORAL RISK FACTOR SURVEILLANCE, P9
   Burns JK, 2015, SOC PSYCH PSYCH EPID, V50, P867, DOI 10.1007/s00127-014-0989-7
   CANNONSPOOR HE, 1982, SCHIZOPHRENIA BULL, V8, P470, DOI 10.1093/schbul/8.3.470
   Caqueo-Urízar A, 2009, HEALTH QUAL LIFE OUT, V7, DOI 10.1186/1477-7525-7-84
   Chan SWC, 2011, ARCH PSYCHIAT NURS, V25, P339, DOI 10.1016/j.apnu.2011.03.008
   Charlson FJ, 2018, SCHIZOPHRENIA BULL, V44, P1195, DOI 10.1093/schbul/sby058
   Cohen A, 2008, SCHIZOPHRENIA BULL, V34, P229, DOI 10.1093/schbul/sbm105
   Cohen A, 2016, BMC PSYCHIATRY, V16, DOI 10.1186/s12888-016-1090-4
   De Hert M, 2009, WORLD PSYCHIATRY, V8, P15
   Demjaha A, 2006, SCHIZOPHR RES, V81, P233
   Demjaha A, 2009, PSYCHOL MED, V39, P1943, DOI 10.1017/S0033291709990651
   Demjaha A, 2012, SCHIZOPHRENIA BULL, V38, P209, DOI 10.1093/schbul/sbr100
   Demyttenaere K, 2004, JAMA-J AM MED ASSOC, V291, P2581, DOI 10.1001/jama.291.21.2581
   DeVylder JE, 2018, JAMA PSYCHIAT, V75, P678, DOI 10.1001/jamapsychiatry.2018.0577
   Di Forti M, 2015, LANCET PSYCHIAT, V2, P233, DOI 10.1016/S2215-0366(14)00117-5
   Díaz-Caneja CM, 2015, NPJ SCHIZOPHR, V1, DOI 10.1038/npjschz.2014.5
   Doherty AM, 2014, SOC PSYCH PSYCH EPID, V49, P673, DOI 10.1007/s00127-014-0847-7
   Drew N, 2011, LANCET, V378, P1664, DOI 10.1016/S0140-6736(11)61458-X
   Fekadu A, 2015, BRIT J PSYCHIAT, V206, P289, DOI 10.1192/bjp.bp.114.149112
   Firth J, 2019, LANCET PSYCHIAT, V6, P675, DOI 10.1016/S2215-0366(19)30132-4
   Gale NK, 2013, BMC MED RES METHODOL, V13, DOI 10.1186/1471-2288-13-117
   Gayer-Anderson C, 2013, EPIDEMIOL PSYCH SCI, V22, P131, DOI 10.1017/S2045796012000406
   Grandon P, 2008, PSYCHIAT RES, V158, P335, DOI 10.1016/j.psychres.2006.12.013
   Groleau Danielle, 2006, Transcult Psychiatry, V43, P671, DOI 10.1177/1363461506070796
   Gureje O, 2005, BRIT J PSYCHIAT, V186, P436, DOI 10.1192/bjp.186.5.436
   Gureje O, 2015, LANCET PSYCHIAT, V2, P168, DOI 10.1016/S2215-0366(15)00013-9
   Harrison G, 2001, BRIT J PSYCHIAT, V178, P506, DOI 10.1192/bjp.178.6.506
   Harrow M, 2005, SCHIZOPHRENIA BULL, V31, P723, DOI 10.1093/schbul/sbi026
   Hjorthoj C, 2017, LANCET PSYCHIAT, V4, P295, DOI 10.1016/S2215-0366(17)30078-0
   Hopper K., 2007, the International Study of Schizophrenia
   Humeniuk R, 2008, ADDICTION, V103, P1039, DOI 10.1111/j.1360-0443.2007.02114.x
   Hutchinson G, 1999, W INDIAN MED J, V48, P81
   Jääskeläinen E, 2013, SCHIZOPHRENIA BULL, V39, P1296, DOI 10.1093/schbul/sbs130
   JABLENSKY A, 1992, PSYCHOL MED, P1
   Jobe TH, 2005, CAN J PSYCHIAT, V50, P892, DOI 10.1177/070674370505001403
   Jongsma HE, 2019, LANCET PUBLIC HEALTH, V4, pE229, DOI 10.1016/S2468-2667(19)30056-8
   Jongsma HE, 2018, JAMA PSYCHIAT, V75, P36, DOI 10.1001/jamapsychiatry.2017.3554
   Joseph L, 2016, ASSESSMENT KNOWLEDGE
   Karterud S., 1998, GLOBAL ASSESSMENT FU
   KAY SR, 1987, SCHIZOPHRENIA BULL, V13, P261, DOI 10.1093/schbul/13.2.261
   Keefe RSE, 2004, SCHIZOPHR RES, V68, P283, DOI 10.1016/j.schres.2003.09.011
   Killaspy H, 2014, INT J SOC PSYCHIATR, V60, P148, DOI 10.1177/0020764012471918
   Kooyman I, 2007, BRIT J PSYCHIAT, V191, pS29, DOI 10.1192/bjp.191.50.s29
   Lêng CH, 2016, SCHIZOPHR RES, V171, P97, DOI 10.1016/j.schres.2016.01.033
   Loganathan Santosh, 2008, Indian J Psychiatry, V50, P39, DOI 10.4103/0019-5545.39758
   Lyngberg K, 2015, SCHIZOPHR RES, V169, P209, DOI 10.1016/j.schres.2015.11.004
   March D, 2008, EPIDEMIOL REV, V30, P84, DOI 10.1093/epirev/mxn006
   Marconi A, 2016, SCHIZOPHRENIA BULL, V42, P1262, DOI 10.1093/schbul/sbw003
   Marwaha S, 2007, BRIT J PSYCHIAT, V191, P30, DOI 10.1192/bjp.bp.105.020982
   Maxwell ME, 1992, MANUAL FOR THE FIGS
   McGrath J, 2008, EPIDEMIOL REV, V30, P67, DOI 10.1093/epirev/mxn001
   McGrath J, 2004, BMC MED, V2, DOI 10.1186/1741-7015-2-13
   McGrath JJ, 2007, ARCH GEN PSYCHIAT, V64, P14, DOI 10.1001/archpsyc.64.1.14
   MCGUFFIN P, 1991, ARCH GEN PSYCHIAT, V48, P764
   Menezes NM, 2006, PSYCHOL MED, V36, P1349, DOI 10.1017/S0033291706007951
   Menezes PR, 2007, BRIT J PSYCHIAT, V191, pS102, DOI 10.1192/bjp.191.51.s102
   Meyer JM, 2009, ACTA PSYCHIAT SCAND, V119, P4, DOI 10.1111/j.1600-0447.2008.01317.x
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P295, DOI 10.1093/schbul/sbs082
   Mohan V, 2007, INDIAN J MED RES, V125, P217
   Mollica R., 2004, Measuring trauma, measuring torture: Instructions and guidance on the utilization of the Harvard Program in Refugee Trauma's versions of The Hopkins Symptom Checklist-25 (HSCL-25) The Harvard Trauma Questionnaire (HTQ)
   Morgan C, 2016, PSYCHOL MED, V46, P1923, DOI 10.1017/S0033291716000441
   Morgan C, 2014, PSYCHOL MED, V44, P2713, DOI 10.1017/S0033291714000282
   Morgan C, 2016, WORLD PSYCHIATRY, V15, P93, DOI 10.1002/wps.20330
   Morgan C, 2015, SOC PSYCH PSYCH EPID, V50, P879, DOI 10.1007/s00127-015-1013-6
   Morgan C, 2010, SCHIZOPHRENIA BULL, V36, P655, DOI 10.1093/schbul/sbq051
   Motrico E, 2013, J AFFECT DISORDERS, V150, P931, DOI 10.1016/j.jad.2013.05.017
   Nortje G, 2016, LANCET PSYCHIAT, V3, P154, DOI 10.1016/S2215-0366(15)00515-5
   Oher FJ, 2014, PSYCHOL MED, V44, P2419, DOI 10.1017/S0033291713003188
   Padmavati R, 2016, INDIAN J MED RES, V143, P395, DOI 10.4103/0971-5916.184280
   Peralta V, 2007, SCHIZOPHR RES, V91, P200, DOI 10.1016/j.schres.2006.12.018
   Quattrone D, 2019, PSYCHOL MED, V49, P1378, DOI 10.1017/S0033291718002131
   Read J, 2005, ACTA PSYCHIAT SCAND, V112, P330, DOI 10.1111/j.1600-0447.2005.00634.x
   Reininghaus U, 2015, SCHIZOPHRENIA BULL, V41, P664, DOI 10.1093/schbul/sbu138
   Saha S, 2007, ARCH GEN PSYCHIAT, V64, P1123, DOI 10.1001/archpsyc.64.10.1123
   Sartorius N, 1996, SOC PSYCH PSYCH EPID, V31, P55, DOI 10.1007/BF00801901
   Scher CD, 2001, J TRAUMA STRESS, V14, P843, DOI 10.1023/A:1013058625719
   Selten JP, 2020, PSYCHOL MED, V50, P303, DOI 10.1017/S0033291719000035
   Stain HJ, 2012, AUST NZ J PSYCHIAT, V46, P879, DOI 10.1177/0004867412449060
   SUSSER E, 1994, ARCH GEN PSYCHIAT, V51, P294
   Tarbox SI, 2013, DEV PSYCHOPATHOL, V25, P1171, DOI 10.1017/S0954579413000448
   Tessler R., 1994, The family burden interview schedule-short form (FBIS/SF)
   Thirthalli J, 2016, LANCET PSYCHIAT, V3, P660, DOI 10.1016/S2215-0366(16)30025-6
   Thrush A, 2014, DISABIL HEALTH J, V7, P262, DOI 10.1016/j.dhjo.2014.01.003
   van der Ven E, 2012, CAN J PSYCHIAT, V57, P300, DOI 10.1177/070674371205700505
   van Nierop M, 2015, PSYCHOL MED, V45, P1277, DOI 10.1017/S0033291714002372
   Van Os J, 1998, SOC PSYCH PSYCH EPID, V33, P596, DOI 10.1007/s001270050099
   VanOs J, 1997, BRIT J PSYCHIAT, V170, P241, DOI 10.1192/bjp.170.3.241
   Waddell L, 2008, J PSYCHOPHARMACOL, V22, P238, DOI 10.1177/0269881107087976
   Waghorn G, 2012, AUST NZ J PSYCHIAT, V46, P774, DOI 10.1177/0004867412452015
NR 98
TC 12
Z9 12
U1 0
U2 1
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD JUN
PY 2020
VL 10
IS 6
AR e039004
DI 10.1136/bmjopen-2020-039004
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA VK5WI
UT WOS:000738458500142
PM 32565481
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, TH
   Hwang, HJ
   Kim, SH
AF Kim, Tae Ho
   Hwang, Hee-Jin
   Kim, Sang-Hwan
TI Relationship between Serum Ferritin Levels and Sarcopenia in Korean
   Females Aged 60 Years and Older Using the Fourth Korea National Health
   and Nutrition Examination Survey (KNHANES IV-2, 3), 2008-2009
SO PLOS ONE
LA English
DT Article
ID INSULIN-RESISTANCE SYNDROME; BODY IRON STORES; METABOLIC SYNDROME;
   OXIDATIVE STRESS; SKELETAL-MUSCLE; DIABETES-MELLITUS;
   GENERAL-POPULATION; ASSOCIATION; OBESITY; ACCUMULATION
AB Context: It has been suggested that elevated serum ferritin is associated with several metabolic disorders. However, there is no reported study assessing any association between serum ferritin and sarcopenia despite the close relationship between sarcopenia and metabolic disorders.
   Objective: We investigated whether serum ferritin was associated with sarcopenia in older Koreans.
   Design and Setting: We conducted a cross-sectional study based on data acquired in the second and third years (2008-9) of the fourth Korean National Health and Nutrition Examination Survey.
   Participants: In total, 952 men (mean age 69.0 years) and 1,380 women (mean age 69.3 years) aged 60 years and older completed a body composition study using dual energy X-ray absorptiometry.
   Measurements: Serum ferritin levels were measured. Sarcopenia was defined as an appendicular skeletal mass as a percentage of body weight that was less than two standard deviations below the gender-specific mean for young adults.
   Results: Serum ferritin levels were lower in women than in men. Women with sarcopenia showed a higher level of serum ferritin than women without sarcopenia (men: without sarcopenia 115.7 ng/mL and with sarcopenia 134.4 ng/mL vs. women: without sarcopenia 70.7 ng/mL and with sarcopenia 85.4 ng/mL). The prevalence of sarcopenia increased as the tertile of serum ferritin increased. However, statistical significance was only seen in elderly women (1st tertile 6.3%, 2nd tertile 8.0%, 3rd tertile 12.0%; p = 0.008). Without adjustment, compared with those in the lowest tertile of serum ferritin level, participants in the highest tertile had an odds ratio of 2.02 (95% confidence interval = 1.26-3.23) for sarcopenia in women. After adjusting for known risk factors, the OR for sarcopenia was 1.74 (95% CI = 1.02-2.97) in women. There was no statistically significant association between sarcopenia and serum ferritin tertiles in men.
   Conclusions: Elevated serum ferritin levels were associated with an increased prevalence of sarcopenia in women but not in men from a representative sample of elderly Koreans.
C1 [Kim, Tae Ho] Kwandong Univ Coll Med, Div Endocrinol, Dept Internal Med, Kangnung, South Korea.
   [Hwang, Hee-Jin] Kwandong Univ Coll Med, Dept Family Med, Kangnung, South Korea.
   [Kim, Sang-Hwan] Myongji Hosp, Geriatr Ctr, Goyang, South Korea.
   [Kim, Sang-Hwan] Myongji Hosp, Dept Family Med, Goyang, South Korea.
C3 Catholic Kwandong University; Catholic Kwandong University; Myongji
   Hospital; Myongji Hospital
RP Hwang, HJ (corresponding author), Kwandong Univ Coll Med, Dept Family Med, Kangnung, South Korea.
EM ydsfm3624@naver.com; fanink@naver.com
OI Kim, Tae Ho/0000-0002-3720-8011
CR Ainsworth BE, 2000, MED SCI SPORT EXER, V32, pS498, DOI 10.1097/00005768-200009001-00009
   Altun M, 2007, MUSCLE NERVE, V36, P223, DOI 10.1002/mus.20808
   Andrews NC, 1999, NEW ENGL J MED, V341, P1986, DOI 10.1056/NEJM199912233412607
   [Anonymous], J NUTR S2
   Baumgartner RN, 2000, ANN NY ACAD SCI, V904, P437
   Beard John L., 2001, Journal of Nutrition, V131, p568S
   Chin SO, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0060119
   Cook JD, 2003, BLOOD, V101, P3359, DOI 10.1182/blood-2002-10-3071
   Cooksey RC, 2004, ENDOCRINOLOGY, V145, P5305, DOI 10.1210/en.2004-0392
   Cruz-Jentoft AJ, 2010, AGE AGEING, V39, P412, DOI 10.1093/ageing/afq034
   Ferrannini E, 2000, LANCET, V355, P2181, DOI 10.1016/S0140-6736(00)02397-7
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Garry PJ, 2000, J AM COLL NUTR, V19, P262, DOI 10.1080/07315724.2000.10718925
   GAVIN MW, 1994, AM J CLIN NUTR, V59, P1376, DOI 10.1093/ajcn/59.6.1376
   Haidari M, 2001, CLIN CHEM, V47, P1666
   Heeney MM, 2004, HEMATOL ONCOL CLIN N, V18, P1379, DOI 10.1016/j.hoc.2004.06.018
   Hofer T, 2008, EXP GERONTOL, V43, P563, DOI 10.1016/j.exger.2008.02.007
   Janssen I, 2002, J AM GERIATR SOC, V50, P889, DOI 10.1046/j.1532-5415.2002.50216.x
   Jehn M, 2004, DIABETES CARE, V27, P2422, DOI 10.2337/diacare.27.10.2422
   Jiang R, 2004, JAMA-J AM MED ASSOC, V291, P711, DOI 10.1001/jama.291.6.711
   Jung SH, 2008, EXP PHYSIOL, V93, P407, DOI 10.1113/expphysiol.2007.039453
   Kalyani RR, 2012, J GERONTOL A-BIOL, V67, P74, DOI 10.1093/gerona/glr022
   Kim CH, 2011, METABOLISM, V60, P414, DOI 10.1016/j.metabol.2010.03.007
   Kim KS, 2012, DIABETES METAB J, V36, P336, DOI 10.4093/dmj.2012.36.5.336
   Kim YS, 2012, J GERONTOL A-BIOL, V67, P1107, DOI 10.1093/gerona/gls071
   KONDO H, 1992, PFLUG ARCH EUR J PHY, V421, P295, DOI 10.1007/BF00374844
   Lee BK, 2011, METABOLISM, V60, P1416, DOI 10.1016/j.metabol.2011.02.008
   Lim S, 2010, DIABETES CARE, V33, P1652, DOI 10.2337/dc10-0107
   Marzetti E, 2009, BIOFACTORS, V35, P28, DOI 10.1002/biof.5
   MERKEL PA, 1988, NEW ENGL J MED, V318, P809, DOI 10.1056/NEJM198803313181303
   MIQUEL J, 1980, EXP GERONTOL, V15, P575, DOI 10.1016/0531-5565(80)90010-8
   Park SK, 2012, DIABETES CARE, V35, P2521, DOI 10.2337/dc12-0543
   ROSENBERG IH, 1989, AM J CLIN NUTR, V50, P1231, DOI 10.1093/ajcn/50.5.1231
   Schrager MA, 2007, J APPL PHYSIOL, V102, P919, DOI 10.1152/japplphysiol.00627.2006
   Seo AY, 2008, AGING CELL, V7, P706, DOI 10.1111/j.1474-9726.2008.00418.x
   Sheu WHH, 2003, CLIN ENDOCRINOL, V58, P380, DOI 10.1046/j.1365-2265.2003.01729.x
   Srikanthan P, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010805
   Tuomainen TP, 1997, DIABETES CARE, V20, P426, DOI 10.2337/diacare.20.3.426
   Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
   Vari IS, 2007, DIABETES CARE, V30, P1795, DOI 10.2337/dc06-2312
   Williams MJA, 2002, ATHEROSCLEROSIS, V165, P179, DOI 10.1016/S0021-9150(02)00233-2
   Wilson JG, 2003, AM J MED SCI, V325, P332, DOI 10.1097/00000441-200306000-00004
   WOLFF SP, 1993, BRIT MED BULL, V49, P642, DOI 10.1093/oxfordjournals.bmb.a072637
   Xu JZ, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002865
   Yao DC, 2005, FREE RADICAL BIO MED, V39, P1385, DOI 10.1016/j.freeradbiomed.2005.07.015
   Yoon JH, 2012, CLIN CHEM LAB MED, V50, P2057, DOI 10.1515/cclm-2011-0928
NR 46
TC 30
Z9 32
U1 0
U2 13
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 25
PY 2014
VL 9
IS 2
AR e90105
DI 10.1371/journal.pone.0090105
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AC2ZX
UT WOS:000332385900117
PM 24587226
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Nankivell, J
   Platania-Phung, C
   Happell, B
   Scott, D
AF Nankivell, Janette
   Platania-Phung, Chris
   Happell, Brenda
   Scott, David
TI Access to Physical Health Care for People with Serious Mental Illness: A
   Nursing Perspective and a Human Rights Perspective-Common Ground?
SO ISSUES IN MENTAL HEALTH NURSING
LA English
DT Article
ID HIGHEST ATTAINABLE STANDARD; METABOLIC SYNDROME; RISK-FACTORS; BARRIERS;
   SCHIZOPHRENIA; PREVALENCE; MORTALITY; CONSUMERS; NURSES; DEATH
AB Relative to the general population, people with serious mental illness (SMI) experience elevated risks of physical disease and illness and live shorter lives. A human rights perspective argues that people with serious mental illness have a right to equal access to physical health care. Nurses in mental health services can contribute to improving the availability and accessibility of physical health care. This study, involving focus group interviews with nurses in a large regional and rural mental health care district of Queensland, Australia, revealed significant problems in access to physical health care for service users. The current article reports on our exploratory analysis of nurses' views and perceptions to identify (1) orientation of nurses to human rights, and (2) access of consumers with SMI to general practitioner services. It was rare for nurses to raise the topic of human rights, and when raised, it was not as a strategy for improving access to physical health care services that they felt consumers with SMI greatly needed. Two main themes were identified as causes of poor access: clinical barriers to physical care and attitudinal barriers to physical care. In light of these results, the authors explore a human rights perspective on access and how this provides an inclusive lobbying umbrella under which nurses and other groups can pursue access to physical health services that are adequate, accessible, and nondiscriminatory. The article then discusses the implications for these findings for the value of human rights as a perspective and means of increasing physical health of people with SMI.
C1 [Nankivell, Janette; Platania-Phung, Chris; Scott, David] Cent Queensland Univ, Inst Hlth & Social Sci Res, Ctr Mental Hlth Nursing Innovat, Melbourne, Vic, Australia.
   [Happell, Brenda] Cent Queensland Univ, Inst Hlth & Social Sci Res, Ctr Mental Hlth Nursing Innovat, Rockhampton, Qld 4702, Australia.
C3 Central Queensland University; Central Queensland University
RP Happell, B (corresponding author), CQUniv Australia, Sch Nursing & Midwifery, Rockhampton, Qld 4701, Australia.
EM b.happell@cqu.edu.au
RI Scott, David/AAE-5031-2021; Happell, Brenda/HSI-0570-2023
OI Scott, David/0000-0001-5226-1972; Happell, Brenda/0000-0002-7293-6583
CR [Anonymous], [No title captured]
   [Anonymous], 2016, Videotape
   [Anonymous], 2018, MENTAL HLTH PRACTICE
   [Anonymous], MENT HLTH SERV AUSTR
   Blythe J, 2012, INT J MENT HEALTH NU, V21, P193, DOI 10.1111/j.1447-0349.2011.00792.x
   Bradshaw T, 2012, INT J MENT HEALTH NU, V21, P266, DOI 10.1111/j.1447-0349.2012.00818.x
   Braun V., 2006, Qual. Res. Psychol., V3, P77, DOI [10.1191/1478088706qp063oa, DOI 10.1191/1478088706QP063OA, DOI 10.1080/10875549.2021.1929659]
   Brown S, 2010, BRIT J PSYCHIAT, V196, P116, DOI 10.1192/bjp.bp.109.067512
   Chadwick A, 2012, INT J MENT HEALTH NU, V21, P211, DOI 10.1111/j.1447-0349.2011.00807.x
   Colton Craig W, 2006, Prev Chronic Dis, V3, pA42
   Davidson S, 2001, AUST NZ J PSYCHIAT, V35, P196, DOI 10.1046/j.1440-1614.2001.00877.x
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P138
   Gray R, 2012, INT J MENT HEALTH NU, V21, P191, DOI 10.1111/j.1447-0349.2012.00832.x
   Happell B., 2012, Mental Health and Physical Activity, V5, P4, DOI DOI 10.1016/J.MHPA.2012.02.005
   Happell Brenda, 2012, Issues Ment Health Nurs, V33, P752, DOI 10.3109/01612840.2012.708099
   Happell B, 2012, INT J MENT HEALTH NU, V21, P236, DOI 10.1111/j.1447-0349.2012.00816.x
   Happell B, 2012, INT J MENT HEALTH NU, V21, P202, DOI 10.1111/j.1447-0349.2011.00799.x
   Hardy S, 2012, INT J MENT HEALTH NU, V21, P289, DOI 10.1111/j.1447-0349.2012.00823.x
   Haupt DW, 2009, AM J PSYCHIAT, V166, P345, DOI 10.1176/appi.ajp.2008.08030383
   Henderson J, 2011, AUST J PRIM HEALTH, V17, P220, DOI 10.1071/PY10063
   Hultsjö S, 2012, INT J MENT HEALTH NU, V21, P480, DOI 10.1111/j.1447-0349.2012.00820.x
   Hunt P, 2007, LANCET, V370, P369, DOI 10.1016/S0140-6736(07)61173-8
   Hyland B, 2003, AUST NZ J PSYCHIAT, V37, P710, DOI 10.1111/j.1440-1614.2003.01264.x
   John AP, 2009, MED J AUSTRALIA, V190, P176, DOI 10.5694/j.1326-5377.2009.tb02342.x
   Lawrence D, 2001, DUTY CARE PREVENTABL
   Lawrence D, 2010, J PSYCHOPHARMACOL, V24, P61, DOI 10.1177/1359786810382058
   Lawrence DM, 2003, BRIT J PSYCHIAT, V182, P31, DOI 10.1192/bjp.182.1.31
   Manderscheid RW, 2009, INT J PUBLIC HEALTH, V54, P7, DOI 10.1007/s00038-009-7076-y
   McCloughen A, 2011, INT J MENT HEALTH NU, V20, P202, DOI 10.1111/j.1447-0349.2010.00721.x
   McSherry B, 2008, J LAW MED, V15, P773
   Muir-Cochrane E, 2006, J PSYCHIATR MENT HLT, V13, P447, DOI 10.1111/j.1365-2850.2006.01002.x
   Newcomer JW, 2007, AM J MANAG CARE, V13, pS170
   Park T, 2011, INT J MENT HEALTH NU, V20, P428, DOI 10.1111/j.1447-0349.2011.00747.x
   Robson D, 2007, INT J NURS STUD, V44, P457, DOI 10.1016/j.ijnurstu.2006.07.013
   Saha S, 2007, ARCH GEN PSYCHIAT, V64, P1123, DOI 10.1001/archpsyc.64.10.1123
   Scott David, 2011, Issues Ment Health Nurs, V32, P589, DOI 10.3109/01612840.2011.569846
   Shanley E, 2003, J Psychiatr Ment Health Nurs, V10, P431, DOI 10.1046/j.1365-2850.2003.00631.x
   Shanley E, 2012, INT J MENT HEALTH NU, V21, P504, DOI 10.1111/j.1447-0349.2012.00817.x
   Simonelli-Muñoz AJ, 2012, INT J MENT HEALTH NU, V21, P220, DOI 10.1111/j.1447-0349.2012.00821.x
   Taylor J, 2009, HEALTH SOC CARE COMM, V17, P216, DOI 10.1111/j.1365-2524.2008.00825.x
   Tirupati S, 2007, AUST NZ J PSYCHIAT, V41, P606, DOI 10.1080/00048670701392841
   United Nations, 1966, International Covenant on Economic, Social and Cultural Rights, The World Declaration on Nutrition, DOI DOI 10.18356/F95A34CA-EN-FR
NR 42
TC 15
Z9 18
U1 0
U2 14
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0161-2840
EI 1096-4673
J9 ISSUES MENT HEALTH N
JI Issues Ment. Health Nurs.
PD JUN
PY 2013
VL 34
IS 6
BP 442
EP 450
DI 10.3109/01612840.2012.754974
PG 9
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA V38TS
UT WOS:000209366300008
PM 23805929
DA 2025-06-11
ER

PT J
AU Chambers, MK
   Thomas, M
   Brimmer, MJ
   Butcher, J
   Griswold, K
AF Chambers, Meghan K.
   Thomas, Matthew
   Brimmer, Maximilian J.
   Butcher, James
   Griswold, Kim
TI Whole Person Care: Outcomes From a 5-Year Care Model Integrating Primary
   Care Into a Behavioral Health Clinic
SO FAMILIES SYSTEMS & HEALTH
LA English
DT Article
DE integrated care; reverse co-location; coordinated care; serious mental
   illness; chronic care outcomes
ID METABOLIC SYNDROME; EXCESS MORTALITY; MENTAL-DISORDERS; SCHIZOPHRENIA;
   ADULTS
AB Introduction: Integrated mental and physical health care has the potential to improve health outcomes. A behavioral health organization established a reverse integration program site using a co-located model to provide primary care services to patients receiving behavioral health services. We ask whether this model of co-located care was effective in improving a range of physical health outcomes for clients. This program was funded with a grant from the Substance Abuse and Mental Health Services Administration Primary and Behavioral Health Care Integration.Method: Patients received services in a community mental health setting that embedded primary care services. The population included adult patients with mental illness, substance use disorder (SUD), or co-occurring medical diagnoses in an urban setting. Just under half of the patients identified as non-White, and over one quarter identified as Hispanic. These characteristics demonstrate a medically complex and underserved population. This description and exploratory analysis utilized National Outcome Measures data and clinical health measures from electronic health records. We stratified data by SUD and mental illness diagnoses. We measured changes in health outcomes for this complex population of 532 patients from 2015 to 2019.Results: From enrollment to last visit, patient outcomes improved for blood pressure and cholesterol. Conversely, waist circumference and breath carbon monoxide levels significantly worsened.Discussion: This reverse integration co-location program demonstrates that positive health outcomes can be achieved through evidence-based care, adaptable clinic arrangements, and robust community connections and support. More work is needed to generate positive health outcomes in medically complex patients.
C1 [Chambers, Meghan K.; Thomas, Matthew; Brimmer, Maximilian J.; Griswold, Kim] SUNY Buffalo, Primary Care Res Inst, Jacobs Sch Med & Biomed Sci, Dept Family Med, Buffalo, NY USA.
   [Butcher, James] BestSelf Behav Hlth Inc, Buffalo, NY USA.
   [Griswold, Kim] SUNY Buffalo, Primary Care Res Inst, Jacobs Sch Med & Biomed Sci, Dept Family Med, 50 Saybrook Pl, Buffalo, NY 14209 USA.
C3 State University of New York (SUNY) System; University at Buffalo, SUNY;
   State University of New York (SUNY) System; University at Buffalo, SUNY
RP Griswold, K (corresponding author), SUNY Buffalo, Primary Care Res Inst, Jacobs Sch Med & Biomed Sci, Dept Family Med, 50 Saybrook Pl, Buffalo, NY 14209 USA.
EM griswol@buffalo.edu
RI Butcher, James/AAC-8339-2020
OI Griswold, Kim/0000-0002-0321-8879; Chambers, Meghan/0000-0001-7932-4427
FU Substance Abuse and Mental Health Services Administration [SM062404-01]
FX This work is supported by the Substance Abuse and Mental Health Services
   Administration (Grant Award Number SM062404-01). The funder did not have
   a role in the preparation of this manuscript.
CR CDC, 2022, MILL HEARTS
   Center of Excellence for Integrated Health Solutions, 2020, CIHS STAND FRAM LEV
   Centers for Medicare and Medicaid Services, 2021, MED HLTH HOM OV
   Chen K, 2008, DIABETES VASC DIS RE, V5, P96, DOI 10.3132/dvdr.2008.016
   Collins C., 2010, EVOLVING MODELS BEHA
   Cunningham C, 2022, PSYCHIAT SERV, V73, P362, DOI 10.1176/appi.ps.22730301
   de Mooij LD, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00855
   Doherty W.J., 1995, FAMILY SYST MED, V13, P275, DOI DOI 10.1037/H0089174
   Errichetti KS, 2020, J GEN INTERN MED, V35, P2035, DOI 10.1007/s11606-020-05778-2
   Falkner B, 2014, CURR HYPERTENS REP, V16, DOI 10.1007/s11906-014-0449-5
   Gerrity M.A., 2016, Evolving models of behavioral health integration: Evidence update 2010-2015
   Hser YI, 2017, J SUBST ABUSE TREAT, V77, P26, DOI 10.1016/j.jsat.2017.03.006
   Janich NK, 2022, COMMUNITY MENT HLT J, V58, P1168, DOI 10.1007/s10597-021-00927-1
   Jones CM, 2019, DRUG ALCOHOL DEPEN, V197, P78, DOI 10.1016/j.drugalcdep.2018.12.030
   Khanassov V, 2016, INT J EQUITY HEALTH, V15, DOI 10.1186/s12939-016-0459-9
   Lawrence D, 2010, CAN J PSYCHIAT, V55, P752, DOI 10.1177/070674371005501202
   Liu NH, 2017, WORLD PSYCHIATRY, V16, P30, DOI 10.1002/wps.20384
   Loeb TB, 2018, PSYCHOL TRAUMA-US, V10, P491, DOI 10.1037/tra0000334
   Mauer BJ, 2006, Behavioral Health/Primary Care Integration: Finance, Policy and Integration of Services
   McEvoy JP, 2005, SCHIZOPHR RES, V80, P19, DOI 10.1016/j.schres.2005.07.014
   McGinty EE, 2021, PSYCHIAT SERV, V72, P1301, DOI 10.1176/appi.ps.202000768
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   National Committee for Quality Assurance, 2021, PAT CTR MED HOM PCMH
   National Institute on Drug Abuse, 2020, DRUGS BRAINS BEH SCI
   National Institute on Drug Abuse, 2020, COMM COM SUBST US DI
   Novacek DM, 2020, PSYCHOL TRAUMA-US, V12, P449, DOI 10.1037/tra0000796
   Olfson M, 2015, JAMA PSYCHIAT, V72, P1172, DOI 10.1001/jamapsychiatry.2015.1737
   Parks J., 2006, Morbidity and mortality in people with serious mental illness
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Perrin Jacob, 2018, N C Med J, V79, P240, DOI 10.18043/ncm.79.4.240
   Santo Jr T, 2022, DRUG ALCOHOL DEPEN, V238, DOI 10.1016/j.drugalcdep.2022.109551
   Scharf Deborah M, 2014, Rand Health Q, V4, P6
   Shackelford J Ryan, 2013, Prim Care Companion CNS Disord, V15, DOI 10.4088/PCC.13m01530
   Shi TH, 2020, PREV CHRONIC DIS, V17, DOI 10.5888/pcd17.200020
   Substance Abuse and Mental Health Services Administration, 2014, PRIM BEH HLTH CAR IN
   Substance Abuse and Mental Health Services Administration Center for Mental Health Services, 2019, NAT OUTC MEAS NOMS C
   Talley RM, 2019, PSYCHIAT SERV, V70, P793, DOI 10.1176/appi.ps.201800480
   Tse J, 2022, PSYCHIAT SERV, V73, P565, DOI 10.1176/appi.ps.202100069
   Ward Martha C, 2017, Focus (Am Psychiatr Publ), V15, P271, DOI 10.1176/appi.focus.20170011
   Wolff LS, 2021, MED CARE, V59, P67, DOI 10.1097/MLR.0000000000001429
   Yancy CW, 2020, JAMA-J AM MED ASSOC, V323, P1891, DOI 10.1001/jama.2020.6548
   Zatloff JP, 2021, COMMUNITY MENT HLT J, V57, P262, DOI 10.1007/s10597-020-00643-2
NR 42
TC 1
Z9 1
U1 1
U2 2
PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA
SN 1091-7527
EI 1939-0602
J9 FAM SYST HEALTH
JI Fam. Syst. Health
PD SEP
PY 2023
VL 41
IS 3
BP 332
EP 341
DI 10.1037/fsh0000794
EA MAR 2023
PG 10
WC Health Care Sciences & Services; Family Studies; Public, Environmental &
   Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Family Studies; Public, Environmental &
   Occupational Health
GA T9IG3
UT WOS:000952301500001
PM 36931824
OA hybrid
DA 2025-06-11
ER

PT J
AU Srisurapanont, M
   Suttajit, S
   Maneeton, N
   Maneeton, B
AF Srisurapanont, Manit
   Suttajit, Sirijit
   Maneeton, Narong
   Maneeton, Benchalak
TI Efficacy and safety of aripiprazole augmentation of clozapine in
   schizophrenia: A systematic review and meta-analysis of
   randomized-controlled trials
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Review
DE Aripiprazole; Drug augmentation; Clozapine; Schizophrenia; Metabolic
   syndrome; Adverse effects
ID TREATMENT-RESISTANT SCHIZOPHRENIA; WEIGHT-GAIN; METABOLIC ABNORMALITIES;
   PHYSICAL ILLNESS; TREATED PATIENTS; DOUBLE-BLIND; MANAGEMENT;
   HALOPERIDOL; COMBINATION; OUTPATIENTS
AB Limited options are available for clozapine-resistant schizophrenia and intolerable side effects of clozapine. We conducted a systematic review of randomized-controlled trials (RU's) to determine the efficacy and safety of aripiprazole augmentation of clozapine for schizophrenia. Electronic databases searched included PubMed, Scopus, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Web of Science. This review synthesized the data of four short-term (8-24 weeks), placebo-controlled trials (N = 347). The overall relative risk (RR, 95% confidence interval) of discontinuation rates was not significantly different between groups (RR = 1.41, 95% CI = 0.78 to 2.56). The pooled standardized mean differences (SMDs, 95% CIs) (Z-test; number of study; I-2-index) suggested trends of aripiprazole augmentation benefits on overall psychotic [-0.40 (-0.87 to 0.07) (n = 3; Z = 1.68, p = 0.09; I-2 = 68%)], positive [-1.05 (-2.39 to 029) (n = 3; Z = 1.54, p = 0.12; I-2 = 94%)], and negative [-0.36 (-0.77 to 0.05) (n = 3; Z = 1.74, p = 0.08; I-2 = 54%)] symptoms. Despite of no benefit on three cardiometabolic indices (i.e., fasting plasma glucose, triglyceride, and high-density lipoprotein), aripiprazole augmentation was superior for weight change with a mean difference (95% CI) of -1.36 kg (-2.35 to -0.36) (n = 3; Z = 2.67, p = 0.008; I-2 = 39%) and LDL-cholesterol with a mean difference of -11.06 mg/dL (-18.25 to -3.87) (n = 3; Z = 3.02, p = 0.003; I-2 = 31%). Aripiprazole augmentation was not correlated with headache and insomnia but significantly associated with agitation/akathesia (RR = 7.59, 95% CI = 1.43 to 40.18) (n = 3; Z = 238, p = 0.02; I-2 = 0%) and anxiety (RR = 2.70, 95% CI = 1.02 to 7.15) (n = 1; Z = 2.00, p = 0.05). The limited short-term data suggested that aripiprazole augmentation of clozapine can minimize the cardiometabolic risk, causes agitation/akathesia, and may be effective in attenuating psychotic symptoms. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Srisurapanont, Manit; Suttajit, Sirijit; Maneeton, Narong; Maneeton, Benchalak] Chiang Mai Univ, Dept Psychiat, Fac Med, Chiang Mai 50200, Thailand.
C3 Chiang Mai University
RP Srisurapanont, M (corresponding author), Chiang Mai Univ, Dept Psychiat, Fac Med, 110 Intavaroros Rd, Chiang Mai 50200, Thailand.
EM manit.s@cmu.ac.th
RI Maneeton, Narong/AGE-3159-2022; Srisurapanont, Manit/R-9997-2017
OI Suttajit, Sirijit/0000-0002-6408-769X; Srisurapanont,
   Manit/0000-0001-6203-1206; Maneeton, Benchalak/0000-0001-6125-6489;
   Maneeton, Narong/0000-0001-6882-6720
FU AstraZeneca; Janssen-Cilag; JohnsonJohnson; Lundbeck; Thai-Otsuka;
   Sanofi-Aventis; Servier; Astra-Zeneca
FX MS received honoraria, consultancy fees, research grants, and/or travel
   reimbursement from AstraZeneca, Janssen-Cilag, Johnson&Johnson,
   Lundbeck, Thai-Otsuka, Sanofi-Aventis, and Servier. SS received
   honoraria and/or consultancy fees from Astra-Zeneca, Janssen-Cilag,
   Lundbeck, and Thai-Otsuka. NM received travel reimbursement from
   Thai-Otsuka and Lundbeck. BM received honoraria and/or travel
   reimbursement from GlaxoSmithKline and Pfizer.
CR [Anonymous], 2004, J CLIN PSYCHIAT, V65, P267
   Barbui C, 2011, J CLIN PSYCHOPHARM, V31, P266, DOI 10.1097/JCP.0b013e318219cba3
   Caemmerer J, 2012, SCHIZOPHR RES, V140, P159, DOI 10.1016/j.schres.2012.03.017
   Chang JS, 2008, J CLIN PSYCHIAT, V69, P720, DOI 10.4088/JCP.v69n0505
   Cipriani A, 2013, J CLIN PSYCHOPHARM, V33, P533, DOI 10.1097/JCP.0b013e318296884f
   Conley RR, 2001, BIOL PSYCHIAT, V50, P898, DOI 10.1016/S0006-3223(01)01271-9
   Croxtall JD, 2012, CNS DRUGS, V26, P155, DOI 10.2165/11208400-000000000-00000
   Davis JM, 2003, ARCH GEN PSYCHIAT, V60, P553, DOI 10.1001/archpsyc.60.6.553
   Davis MC, 2014, ACTA PSYCHIAT SCAND, V130, P30, DOI 10.1111/acps.12233
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P138
   DERSIMONIAN R, 1986, CONTROL CLIN TRIALS, V7, P177, DOI 10.1016/0197-2456(86)90046-2
   Essali A, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD000059.pub2
   Fan X, 2013, ACTA PSYCHIAT SCAND, V127, P217, DOI 10.1111/acps.12009
   Fleischhacker WW, 2010, INT J NEUROPSYCHOPH, V13, P1115, DOI 10.1017/S1461145710000490
   Harrison TS, 2004, DRUGS, V64, P1715
   Hatala R, 2005, CAN MED ASSOC J, V172, P661, DOI 10.1503/cmaj.1031920
   Henderson DC, 2006, ACTA PSYCHIAT SCAND, V113, P142, DOI 10.1111/j.1600-0447.2005.00612.x
   Higgins JPT, 2003, BMJ-BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557
   Higgins J, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.ED000049
   Higgins JPT, 2009, J R STAT SOC A STAT, V172, P137, DOI 10.1111/j.1467-985X.2008.00552.x
   Kennedy JL, 2014, INT CLIN PSYCHOPHARM, V29, P63, DOI 10.1097/YIC.0b013e32836508e6
   Lançon C, 2006, INT J PSYCHIAT CLIN, V10, P131, DOI 10.1080/13651500600579290
   Leucht S, 2007, ACTA PSYCHIAT SCAND, V116, P317, DOI 10.1111/j.1600-0447.2007.01095.x
   Lieberman JA, 2005, NEW ENGL J MED, V353, P1209, DOI 10.1056/NEJMoa051688
   Maayan L, 2010, NEUROPSYCHOPHARMACOL, V35, P1520, DOI 10.1038/npp.2010.21
   Marder SR, 2003, SCHIZOPHR RES, V61, P123, DOI 10.1016/S0920-9964(03)00050-1
   McEvoy JP, 2006, AM J PSYCHIAT, V163, P600, DOI 10.1176/appi.ajp.163.4.600
   Meltzer HY, 2003, ARCH GEN PSYCHIAT, V60, P82, DOI 10.1001/archpsyc.60.1.82
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Mitsonis CI, 2007, PROG NEURO-PSYCHOPH, V31, P373, DOI 10.1016/j.pnpbp.2006.09.015
   Miyamoto S, 2014, J PSYCHIATR RES, V58, P1, DOI 10.1016/j.jpsychires.2014.07.001
   Mizuno Y, 2014, SCHIZOPHRENIA BULL, V40, P1385, DOI 10.1093/schbul/sbu030
   Moher D, 2009, J CLIN EPIDEMIOL, V62, P1006, DOI 10.1016/j.jclinepi.2009.06.005
   Mossaheb N, 2012, NEUROPSYCH DIS TREAT, V8, P235, DOI 10.2147/NDT.S13830
   Muscatello MRA, 2011, SCHIZOPHR RES, V127, P93, DOI 10.1016/j.schres.2010.12.011
   Osser DN, 2013, HARVARD REV PSYCHIAT, V21, P18, DOI 10.1097/HRP.0b013e31827fd915
   Porcelli S, 2012, EUR NEUROPSYCHOPHARM, V22, P165, DOI 10.1016/j.euroneuro.2011.08.005
   Sommer IE, 2012, SCHIZOPHRENIA BULL, V38, P1003, DOI 10.1093/schbul/sbr004
   Stip E, 2010, CLIN THER, V32, pS3, DOI 10.1016/j.clinthera.2010.01.021
   Taylor DM, 2012, ACTA PSYCHIAT SCAND, V125, P15, DOI 10.1111/j.1600-0447.2011.01792.x
   Tiihonen J, 2009, LANCET, V374, P620, DOI 10.1016/S0140-6736(09)60742-X
   Vayisoglu S, 2013, SCHIZOPHR RES, V143, P207, DOI 10.1016/j.schres.2012.11.006
   Ziegenbein M, 2006, CLIN DRUG INVEST, V26, P117, DOI 10.2165/00044011-200626030-00001
NR 43
TC 44
Z9 44
U1 0
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD MAR
PY 2015
VL 62
BP 38
EP 47
DI 10.1016/j.jpsychires.2015.01.004
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CE4GS
UT WOS:000351789700005
PM 25619176
DA 2025-06-11
ER

PT J
AU Liu, CS
   Carvalho, AF
   McIntyre, RS
AF Liu, Celina S.
   Carvalho, Andre F.
   McIntyre, Roger S.
TI Towards a "Metabolic" Subtype of Major Depressive Disorder: Shared
   Pathophysiological Mechanisms May Contribute to Cognitive Dysfunction
SO CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
LA English
DT Article
DE Body mass index; cognition; co-morbidity; major depressive disorder;
   metabolic disorders; obesity
ID GLUCAGON-LIKE PEPTIDE-1; HIPPOCAMPAL SYNAPTIC PLASTICITY;
   CENTRAL-NERVOUS-SYSTEM; NECROSIS-FACTOR-ALPHA; QUALITY-OF-LIFE;
   NEUROTROPHIC FACTOR; INSULIN-RESISTANCE; OXIDATIVE STRESS; RISK-FACTORS;
   INTRANASAL INSULIN
AB Major depressive disorder (MDD) is frequently associated with significant cognitive dysfunction. Furthermore, MDD is often co-morbid with obesity and metabolic disorders. The aim of this review is to evaluate the pathophysiological role obesity and co-morbid metabolic disorders may play in cognitive dysfunction associated with MDD. We conducted a PubMed search from December 1st 2013 to May 31st 2014 of all English language publications including the following keywords: cognition, working memory, attention, executive functioning, inflammation, insulin, brain-derived neurotrophic factor, neurotrophins, incretins, glucagon-like peptide-1, adipokines, diabetes, oxidative stress and glucocorticoids, cross-referenced with MDD and obesity, metabolic disorders, or metabolic syndrome. Clinical and epidemiological studies indicate that metabolic disturbances may contribute to cognitive dysfunction in MDD. There are several overlapping pathophysiological mechanisms linking obesity and metabolic abnormalities to MDD including disturbances in the hypothalamic pituitary adrenal axis, abnormalities in brain-derived neurotrophic factor signaling, adipose-derived hormones, insulin signalling, inflammatory cytokines, as well as oxidative and nitrosative stress pathways. Based on current research results, this article presents several putative mechanisms underlying the effects of obesity and metabolic abnormalities on cognitive dysfunction in MDD. Metabolic MDD may represent a depression subtype with unique patho-etiological mechanisms. The diverse shared pathophysiological mechanisms elucidated in this review may provide novel targets for the prevention and/or treatment of cognitive deficits in MDD.
C1 [Liu, Celina S.] Univ Toronto, Dept Human Biol, Toronto, ON, Canada.
   [Liu, Celina S.; McIntyre, Roger S.] Toronto Western Hosp, Mood Disorders Psychopharmacol Unit, Toronto, ON M5T 2S8, Canada.
   [Carvalho, Andre F.] Univ Fed Ceara, Translat Psychiat Res Grp, Fortaleza, Ceara, Brazil.
   [Carvalho, Andre F.] Univ Fed Ceara, Dept Clin Med, Fortaleza, Ceara, Brazil.
   [McIntyre, Roger S.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [McIntyre, Roger S.] Univ Toronto, Dept Pharmacol, Toronto, ON, Canada.
C3 University of Toronto; University of Toronto; University Health Network
   Toronto; Universidade Federal do Ceara; Universidade Federal do Ceara;
   University of Toronto; University of Toronto
RP Liu, CS (corresponding author), Univ Toronto, Dept Human Biol, Toronto, ON, Canada.
EM celina.liu@mail.utoronto.ca
RI McIntyre, Roger/AAU-1000-2020; Carvalho, Andre/AEZ-4001-2022
FU Conselho de Desenvolvimento Cientifico e Tecnologico (Level II, Brazil)
FX AFC is funded by a research scholarship award from Conselho de
   Desenvolvimento Cientifico e Tecnologico (Level II, Brazil). CSL would
   like to acknowledge J. Lieu from the University of Toronto.
CR ACHESON A, 1995, NATURE, V374, P450, DOI 10.1038/374450a0
   Air EL, 2002, ENDOCRINOLOGY, V143, P2449, DOI 10.1210/en.143.6.2449
   Alexopoulos GS, 1997, AM J PSYCHIAT, V154, P562
   Alexopoulos GS, 1997, ARCH GEN PSYCHIAT, V54, P915
   Anderson G, 2013, CURR PHARM DESIGN, V46, P224
   Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   André C, 2014, BRAIN BEHAV IMMUN, V41, P10, DOI 10.1016/j.bbi.2014.03.012
   Antonijevic IA, 1998, J PSYCHIAT RES, V32, P403, DOI 10.1016/S0022-3956(98)00032-6
   Arango V, 2002, PROG BRAIN RES, V136, P443
   Arita Y, 1999, BIOCHEM BIOPH RES CO, V257, P79, DOI 10.1006/bbrc.1999.0255
   Arterburn D, 2012, OBES RES CLIN PRACT, V6, pE197, DOI 10.1016/j.orcp.2012.02.007
   AXELSON DA, 1993, PSYCHIAT RES, V47, P163, DOI 10.1016/0165-1781(93)90046-J
   BANKI CM, 1981, ARCH PSYCHIAT NERVEN, V229, P345, DOI 10.1007/BF01833162
   Banks WA, 2012, PHARMACOL THERAPEUT, V136, P82, DOI 10.1016/j.pharmthera.2012.07.006
   BASKIN DG, 1983, ENDOCRINOLOGY, V112, P898, DOI 10.1210/endo-112-3-898
   Bazakis AM, 2005, EMERG MED CLIN N AM, V23, P901, DOI 10.1016/j.emc.2005.03.004
   Belanoff JK, 2001, AM J PSYCHIAT, V158, P1612, DOI 10.1176/appi.ajp.158.10.1612
   Benraiss A, 2001, J NEUROSCI, V21, P6718, DOI 10.1523/JNEUROSCI.21-17-06718.2001
   Berg AH, 2002, TRENDS ENDOCRIN MET, V13, P84, DOI 10.1016/S1043-2760(01)00524-0
   Bian SS, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-106
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   Bjorntorp P, 1997, NUTRITION, V13, P795, DOI 10.1016/S0899-9007(97)00191-3
   Bjorntorp P, 1996, INT J OBESITY, V20, P291
   Bondia-Pons I, 2012, J PHYSIOL BIOCHEM, V68, P701, DOI 10.1007/s13105-012-0154-2
   Bornstein SR, 2006, MOL PSYCHIATR, V11, P892, DOI 10.1038/sj.mp.4001873
   Brandacher G, 2006, OBES SURG, V16, P541, DOI 10.1381/096089206776945066
   Bray GA, 2006, J MED CHEM, V49, P4001, DOI 10.1021/jm0680124
   Brunetti L, 2004, EUR J PHARMACOL, V493, P41, DOI 10.1016/j.ejphar.2004.04.020
   Brüning JC, 2000, SCIENCE, V289, P2122, DOI 10.1126/science.289.5487.2122
   Buettner R, 2007, OBESITY, V15, P798, DOI 10.1038/oby.2007.608
   Cabou C, 2008, DIABETES, V57, P2577, DOI 10.2337/db08-0121
   Calder PC, 2008, PROSTAG LEUKOTR ESS, V79, P101, DOI 10.1016/j.plefa.2008.09.016
   Capuron L, 2003, BRAIN BEHAV IMMUN, V17, pS119
   Capuron L, 2001, PSYCHONEUROENDOCRINO, V26, P797, DOI 10.1016/S0306-4530(01)00030-0
   Cardoso S, 2013, NEUROBIOL DIS, V49, P1, DOI 10.1016/j.nbd.2012.08.008
   Castrén E, 2007, CURR OPIN PHARMACOL, V7, P18, DOI 10.1016/j.coph.2006.08.009
   Castrén E, 2010, DEV NEUROBIOL, V70, P289, DOI 10.1002/dneu.20758
   Cefalu WT, 2012, AM J MED SCI, V343, P21, DOI 10.1097/MAJ.0b013e31823ea4af
   Chai WW, 2010, NUTR RES, V30, P227, DOI 10.1016/j.nutres.2010.04.006
   Chess AC, 2007, SCHIZOPHRENIA BULL, V33, P797, DOI 10.1093/schbul/sbl033
   Chess AC, 2006, BEHAV BRAIN RES, V170, P326, DOI 10.1016/j.bbr.2006.03.006
   Chrysohoou C, 2007, NUTR METAB CARDIOVAS, V17, P590, DOI 10.1016/j.numecd.2006.05.007
   Conner JM, 1997, J NEUROSCI, V17, P2295
   Cotman CW, 2002, TRENDS NEUROSCI, V25, P295, DOI 10.1016/S0166-2236(02)02143-4
   Craft S, 2004, LANCET NEUROL, V3, P169, DOI 10.1016/S1474-4422(04)00681-7
   CURZON G, 1979, ANN BIOL CLIN-PARIS, V37, P27
   Danese A, 2014, MOL PSYCHIATR, V19, P544, DOI 10.1038/mp.2013.54
   Dash SK, 2013, RECENT PATENTS ENDOC, V7, P155, DOI 10.2174/1872214811307020009
   DEMYER MK, 1981, ARCH GEN PSYCHIAT, V38, P642
   den Heijer T, 2003, DIABETOLOGIA, V46, P1604, DOI 10.1007/s00125-003-1235-0
   Deng YF, 2010, ANN NY ACAD SCI, V1212, pE1, DOI 10.1111/j.1749-6632.2010.05875.x
   Desbriere R, 2006, OBESITY, V14, P794, DOI 10.1038/oby.2006.92
   Deuschle M, 1996, HORM METAB RES, V28, P714, DOI 10.1055/s-2007-979885
   Doherty G.H., 2011, CURR GERONTOL GERIAT, V2011
   Dortland AKBV, 2012, PROG NEURO-PSYCHOPH, V36, P85, DOI 10.1016/j.pnpbp.2011.10.001
   Duman RS, 2006, BIOL PSYCHIAT, V59, P1116, DOI 10.1016/j.biopsych.2006.02.013
   Duman RS, 2002, EUR PSYCHIAT, V17, p306S
   Duman RS, 2004, BIOL PSYCHIAT, V56, P140, DOI 10.1016/j.biopsych.2004.02.033
   During MJ, 2003, NAT MED, V9, P1173, DOI 10.1038/nm919
   Egan MF, 2003, CELL, V112, P257, DOI 10.1016/S0092-8674(03)00035-7
   El-Haschimi K, 2000, J CLIN INVEST, V105, P1827, DOI 10.1172/JCI9842
   Ellis Amy, 2013, Journal of Nutrition in Gerontology and Geriatrics, V32, P263, DOI 10.1080/21551197.2013.842199
   Elmquist JK, 1998, NAT NEUROSCI, V1, P445, DOI 10.1038/2164
   Fasshauer M, 2002, BIOCHEM BIOPH RES CO, V290, P1084, DOI 10.1006/bbrc.2001.6307
   Fergenbaum JH, 2009, OBESITY, V17, P1957, DOI 10.1038/oby.2009.161
   Fernandez-Real JM, 2003, INT J OBESITY, V27, P1552, DOI 10.1038/sj.ijo.0802472
   FERNSTROM JD, 1983, PHYSIOL REV, V63, P484, DOI 10.1152/physrev.1983.63.2.484
   Ferrucci L, 2006, J CLIN ENDOCR METAB, V91, P439, DOI 10.1210/jc.2005-1303
   FIGIEL GS, 1991, NEUROBIOL AGING, V12, P245, DOI 10.1016/0197-4580(91)90104-R
   FINKELSTEIN JA, 1982, PHARMACOL BIOCHEM BE, V17, P939, DOI 10.1016/0091-3057(82)90476-2
   Forbes LE, 2013, CAN J PUBLIC HEALTH, V104, pE490, DOI 10.17269/cjph.104.4042
   Francis GJ, 2008, BRAIN, V131, P3311, DOI 10.1093/brain/awn288
   Freeman LR, 2013, FREE RADICAL BIO MED, V56, P226, DOI 10.1016/j.freeradbiomed.2012.08.577
   Frodl T, 2013, NEUROBIOL DIS, V52, P24, DOI 10.1016/j.nbd.2012.03.012
   Galan P, 2005, EUR J CLIN NUTR, V59, P1181, DOI 10.1038/sj.ejcn.1602230
   Galecki P, 2013, NEUROENDOCRINOL LETT, V34, P780
   Gano LB, 2011, PHYSIOL GENOMICS, V43, P895, DOI 10.1152/physiolgenomics.00204.2010
   Gault VA, 2010, INT J OBESITY, V34, P1341, DOI 10.1038/ijo.2010.59
   Gertsik L, 2012, J CLIN PSYCHOPHARM, V32, P61, DOI 10.1097/JCP.0b013e31823f3b5f
   Gold PW, 2002, MOL PSYCHIATR, V7, P254, DOI 10.1038/sj.mp.4001032
   Gómez-Ambrosi J, 2001, ANN INTERN MED, V135, P306, DOI 10.7326/0003-4819-135-4-200108210-00030
   Goveas JS, 2014, J GERIATR PSYCH NEUR, V27, P94, DOI 10.1177/0891988714522697
   Grigoleit JS, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0028330
   Halliwell B, 2006, J NEUROCHEM, V97, P1634, DOI 10.1111/j.1471-4159.2006.03907.x
   Hasselbalch BJ, 2012, NEUROPSYCHOLOGY, V26, P642, DOI 10.1037/a0029301
   HAVRANKOVA J, 1978, NATURE, V272, P827, DOI 10.1038/272827a0
   Herieka M, 2014, MOL NUTR FOOD RES, V58, P136, DOI 10.1002/mnfr.201300104
   HICKIE I, 1995, BIOL PSYCHIAT, V37, P151, DOI 10.1016/0006-3223(94)00174-2
   HOES MJAJM, 1981, PSYCHOPHARMACOLOGY, V75, P346, DOI 10.1007/BF00435850
   Hryhorczuk C, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00177
   Huang EJ, 2001, ANNU REV NEUROSCI, V24, P677, DOI 10.1146/annurev.neuro.24.1.677
   Isacson R, 2011, EUR J PHARMACOL, V650, P249, DOI 10.1016/j.ejphar.2010.10.008
   Jagielski AC, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0092859
   Jamal M, 2012, DRUG ALCOHOL DEPEN, V126, P138, DOI 10.1016/j.drugalcdep.2012.05.001
   Jazayeri S, 2008, AUST NZ J PSYCHIAT, V42, P192, DOI 10.1080/00048670701827275
   JOSEPH MS, 1984, PSYCHIAT RES, V11, P185, DOI 10.1016/0165-1781(84)90067-2
   Jow GM, 2006, J AFFECT DISORDERS, V90, P21, DOI 10.1016/j.jad.2005.09.015
   Juruena Mario F, 2004, Braz. J. Psychiatry, V26, P189, DOI 10.1590/S1516-44462004000300009
   Juruena MF, 2006, PSYCHOPHARMACOLOGY, V189, P225, DOI 10.1007/s00213-006-0555-4
   Juruena MF, 2014, EPILEPSY BEHAV, V38, P148, DOI 10.1016/j.yebeh.2013.10.020
   Kaidanovich-Beilin Oksana, 2012, F1000 Biol Rep, V4, P14, DOI 10.3410/B4-14
   Kan C, 2013, DIABETES CARE, V36, P480, DOI 10.2337/dc12-1442
   Karege F, 2005, BIOL PSYCHIAT, V57, P1068, DOI 10.1016/j.biopsych.2005.01.008
   Kernie SG, 2000, EMBO J, V19, P1290, DOI 10.1093/emboj/19.6.1290
   Kiecolt-Glaser JK, 2012, BRAIN BEHAV IMMUN, V26, P988, DOI 10.1016/j.bbi.2012.05.011
   Könner AC, 2011, CELL METAB, V13, P720, DOI 10.1016/j.cmet.2011.03.021
   KOKAIA M, 1995, EXP NEUROL, V133, P215, DOI 10.1006/exnr.1995.1024
   Krishnan KRR, 1997, AM J PSYCHIAT, V154, P497
   KRISHNAN KRR, 1995, MED HYPOTHESES, V44, P111
   Kudlow PA, 2013, SLEEP MED, V14, P943, DOI 10.1016/j.sleep.2013.04.017
   Kwon Hyokjoon, 2013, Front Endocrinol (Lausanne), V4, P71, DOI 10.3389/fendo.2013.00071
   Lapin IP, 2003, ADV EXP MED BIOL, V527, P121
   Lee IM, 2012, MED SCI SPORT EXER, V44, P1088, DOI 10.1249/MSS.0b013e318242b11a
   Lee RSC, 2012, J AFFECT DISORDERS, V140, P113, DOI 10.1016/j.jad.2011.10.023
   Lee SY, 2013, PROG NEURO-PSYCHOPH, V46, P224, DOI 10.1016/j.pnpbp.2012.09.008
   Leo R, 2006, NEUROSCI LETT, V407, P211, DOI 10.1016/j.neulet.2006.08.043
   Lesser IM, 1996, AM J PSYCHIAT, V153, P1280
   Li SX, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0096368
   Lin CH, 2014, J AFFECT DISORDERS, V161, P123, DOI 10.1016/j.jad.2014.02.039
   Lindholm JSO, 2014, FRONT BEHAV NEUROSCI, V8, DOI 10.3389/fnbeh.2014.00143
   Linnarsson S, 1997, EUR J NEUROSCI, V9, P2581, DOI 10.1111/j.1460-9568.1997.tb01687.x
   Liu CS, 2013, ADV THER, V30, P987, DOI 10.1007/s12325-013-0067-7
   LOHOF AM, 1993, NATURE, V363, P350, DOI 10.1038/363350a0
   Lu XY, 2007, CURR OPIN PHARMACOL, V7, P648, DOI 10.1016/j.coph.2007.10.010
   Lu XY, 2006, P NATL ACAD SCI USA, V103, P1593, DOI 10.1073/pnas.0508901103
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Macht M, 2008, APPETITE, V50, P1, DOI 10.1016/j.appet.2007.07.002
   Mackay GM, 2006, EUR J NEUROL, V13, P30, DOI 10.1111/j.1468-1331.2006.01220.x
   Maes M, 2011, PROG NEURO-PSYCHOPH, V35, P702, DOI 10.1016/j.pnpbp.2010.12.017
   MAES M, 1994, PSYCHIAT RES, V54, P143, DOI 10.1016/0165-1781(94)90003-5
   Maes M, 2012, J AFFECT DISORDERS, V141, P55, DOI 10.1016/j.jad.2012.02.023
   Maes M, 2012, PSYCHIAT RES, V196, P243, DOI 10.1016/j.psychres.2011.09.029
   Maes M, 2011, NEUROENDOCRINOL LETT, V32, P7
   Malone KM, 2003, AM J PSYCHIAT, V160, P773, DOI 10.1176/appi.ajp.160.4.773
   Martinho KO, 2013, ARCH GERONTOL GERIAT, V57, P151, DOI 10.1016/j.archger.2013.04.005
   MCGOWAN MK, 1993, PHYSIOL BEHAV, V54, P1031, DOI 10.1016/0031-9384(93)90320-F
   McIntyre Roger S, 2007, Ann Clin Psychiatry, V19, P257, DOI 10.1080/10401230701653377
   McIntyre RS, 2014, J AFFECT DISORDERS, V156, P1, DOI 10.1016/j.jad.2013.10.043
   McIntyre RS, 2013, BEHAV BRAIN RES, V237, P164, DOI 10.1016/j.bbr.2012.09.021
   Medina-Gómez G, 2012, BEST PRACT RES CL EN, V26, P791, DOI 10.1016/j.beem.2012.06.002
   MERLIO JP, 1993, NEURON, V10, P151, DOI 10.1016/0896-6273(93)90307-D
   Millan MJ, 2012, NAT REV DRUG DISCOV, V11, P141, DOI 10.1038/nrd3628
   Miller AH, 2009, BIOL PSYCHIAT, V65, P732, DOI 10.1016/j.biopsych.2008.11.029
   Monteleone P, 2008, BIPOLAR DISORD, V10, P95, DOI 10.1111/j.1399-5618.2008.00459.x
   Morgan VA, 2014, PSYCHOL MED, V44, P2163, DOI 10.1017/S0033291713002973
   Morikawa M, 2013, INT J GERIATR PSYCH, V28, P1251, DOI 10.1002/gps.3950
   Moylan S, 2013, MOL PSYCHIATR, V18, P595, DOI 10.1038/mp.2012.33
   Münzberg H, 2005, NAT NEUROSCI, V8, P566, DOI 10.1038/nn1454
   Murakami K, 2008, NUTR RES, V28, P309, DOI 10.1016/j.nutres.2008.03.008
   Napoli N, 2014, AM J CLIN NUTR, V100, P189, DOI 10.3945/ajcn.113.082883
   Narita K, 2006, PROG NEURO-PSYCHOPH, V30, P1159, DOI 10.1016/j.pnpbp.2006.03.030
   Nauck MA, 2011, AM J MED, V124, pS19, DOI 10.1016/j.amjmed.2010.11.002
   Navarro M, 1996, J NEUROCHEM, V67, P1982
   Niinisalo P, 2008, SCAND J CLIN LAB INV, V68, P767, DOI 10.1080/00365510802245685
   Novak V, 2014, DIABETES CARE, V37, P751, DOI 10.2337/dc13-1672
   O'Connor JC, 2009, MOL PSYCHIATR, V14, P511, DOI 10.1038/sj.mp.4002148
   Okamoto M, 2008, DIABETOLOGIA, V51, P827, DOI 10.1007/s00125-008-0944-9
   Okamura F, 2000, METABOLISM, V49, P1255, DOI 10.1053/meta.2000.9515
   Ouchi N, 2003, CURR OPIN LIPIDOL, V14, P561, DOI 10.1097/00041433-200312000-00003
   Pace TWW, 2009, ANN NY ACAD SCI, V1179, P86, DOI 10.1111/j.1749-6632.2009.04984.x
   Palta P, 2014, J INT NEUROPSYCH SOC, V20, P278, DOI 10.1017/S1355617713001483
   Pandina GJ, 2009, J AFFECT DISORDERS, V118, P139, DOI 10.1016/j.jad.2009.02.019
   Pannekoek JN, 2014, NEUROIMAGE-CLIN, V4, P336, DOI 10.1016/j.nicl.2014.01.007
   Papakostas GI, 2014, J CLIN PSYCHIAT, V75, P8, DOI 10.4088/JCP.13r08710
   Papakostas GI, 2005, INT J NEUROPSYCHOPH, V8, P59, DOI 10.1017/S1461145704004602
   Papakostas GI, 2004, GEN HOSP PSYCHIAT, V26, P13, DOI 10.1016/j.genhosppsych.2003.07.004
   Park HR, 2010, NEUROSCI LETT, V482, P235, DOI 10.1016/j.neulet.2010.07.046
   Park H, 2013, NAT REV NEUROSCI, V14, P7, DOI 10.1038/nrn3379
   Pasco JA, 2008, BRIT J PSYCHIAT, V193, P322, DOI 10.1192/bjp.bp.107.046706
   Pasco JA, 2008, J AFFECT DISORDERS, V107, P221, DOI 10.1016/j.jad.2007.07.024
   Patton GC, 1998, AM J PUBLIC HEALTH, V88, P1518, DOI 10.2105/AJPH.88.10.1518
   Pedersen W, 2009, ADDICTION, V104, P129, DOI 10.1111/j.1360-0443.2008.02395.x
   Pencea V, 2001, J NEUROSCI, V21, P6706, DOI 10.1523/JNEUROSCI.21-17-06706.2001
   Pertovaara M, 2007, CLIN EXP IMMUNOL, V148, P106, DOI 10.1111/j.1365-2249.2007.03325.x
   Prestele S, 2003, FORTSCHR NEUROL PSYC, V71, P24, DOI 10.1055/s-2003-36684
   Rajala MW, 2003, J CLIN INVEST, V111, P225, DOI 10.1172/JCI200316521
   Ramasubbu R, 2014, FRONT PSYCHIATRY, V5, DOI 10.3389/fpsyt.2014.00017
   Rea R, 2004, DIABETES OBES METAB, V6, P163, DOI 10.1111/j.1462-8902.2004.00334.x
   Reger MA, 2008, NEUROLOGY, V70, P440, DOI 10.1212/01.WNL.0000265401.62434.36
   Reichenberg A, 2001, ARCH GEN PSYCHIAT, V58, P445, DOI 10.1001/archpsyc.58.5.445
   Reuben DB, 2003, J AM GERIATR SOC, V51, P1125, DOI 10.1046/j.1532-5415.2003.51380.x
   Rock PL, 2014, PSYCHOL MED, V44, P2029, DOI 10.1017/S0033291713002535
   Rosenblat JD, 2014, PROG NEURO-PSYCHOPH, V53, P23, DOI 10.1016/j.pnpbp.2014.01.013
   Rosická M, 2003, PHYSIOL RES, V52, P61, DOI 10.33549/physiolres.930301
   Rothman SM, 2012, ANN NY ACAD SCI, V1264, P49, DOI 10.1111/j.1749-6632.2012.06525.x
   Rubin RT, 2002, PSYCHIAT RES, V113, P255, DOI 10.1016/S0165-1781(02)00263-9
   Russo-Neustadt A, 1999, NEUROPSYCHOPHARMACOL, V21, P679, DOI 10.1016/S0893-133X(99)00059-7
   Salloway S, 1996, NEUROLOGY, V46, P1567, DOI 10.1212/WNL.46.6.1567
   Santos S, 2013, NUTR RES, V33, P687, DOI 10.1016/j.nutres.2013.07.002
   Sanz CM, 2013, DIABETES CARE, V36, P1512, DOI 10.2337/dc12-1017
   Sen S, 2008, BIOL PSYCHIAT, V64, P527, DOI 10.1016/j.biopsych.2008.05.005
   Sharma S, 2013, INT J OBESITY, V37, P382, DOI 10.1038/ijo.2012.48
   SIMOPOULOS AP, 1991, AM J CLIN NUTR, V54, P438, DOI 10.1093/ajcn/54.3.438
   Soczynska JK, 2011, NEUROMOL MED, V13, P93, DOI 10.1007/s12017-010-8140-8
   Steffens DC, 1998, BIOL PSYCHIAT, V43, P705, DOI 10.1016/S0006-3223(98)00084-5
   Stockmeier CA, 2003, J PSYCHIAT RES, V37, P357, DOI 10.1016/S0022-3956(03)00050-5
   Stranahan AM, 2008, HIPPOCAMPUS, V18, P1085, DOI 10.1002/hipo.20470
   Taguchi A, 2007, SCIENCE, V317, P369, DOI 10.1126/science.1142179
   Tahrani AA, 2011, LANCET, V378, P182, DOI 10.1016/S0140-6736(11)60207-9
   Taylor VH, 2010, J OBES, V2010, DOI 10.1155/2010/748048
   Thaler JP, 2010, FRONT NEUROENDOCRIN, V31, P79, DOI 10.1016/j.yfrne.2009.10.002
   THORENS B, 1992, P NATL ACAD SCI USA, V89, P8641, DOI 10.1073/pnas.89.18.8641
   Tiwari Hemant K., 2011, Frontiers in Genetics, V2, DOI 10.3389/fgene.2011.00056
   Turton MD, 1996, NATURE, V379, P69, DOI 10.1038/379069a0
   Ukkola O, 2002, EUR J ENDOCRINOL, V147, P571, DOI 10.1530/eje.0.1470571
   UNGER JW, 1991, NEUROSCIENCE, V42, P853, DOI 10.1016/0306-4522(91)90049-T
   Unger TJ, 2007, J NEUROSCI, V27, P14265, DOI 10.1523/JNEUROSCI.3308-07.2007
   van den Berg E, 2010, DIABETOLOGIA, V53, P58, DOI 10.1007/s00125-009-1571-9
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Nunes SOV, 2013, NEUROSCI BIOBEHAV R, V37, P1336, DOI 10.1016/j.neubiorev.2013.04.014
   Nunes SOV, 2012, NICOTINE TOB RES, V14, P540, DOI 10.1093/ntr/ntr247
   Vaswani M, 2003, PROG NEURO-PSYCHOPH, V27, P85, DOI 10.1016/S0278-5846(02)00338-X
   Viscogliosi G, 2013, INT J GERIATR PSYCH, V28, P242, DOI 10.1002/gps.3817
   Vogelzangs N, 2014, NEUROPSYCHOPHARMACOL, V39, P1624, DOI 10.1038/npp.2014.9
   Volkow ND, 2011, TRENDS COGN SCI, V15, P37, DOI 10.1016/j.tics.2010.11.001
   Wagner S, 2012, ACTA PSYCHIAT SCAND, V125, P281, DOI 10.1111/j.1600-0447.2011.01762.x
   Wang YY, 2012, KAOHSIUNG J MED SCI, V28, P607, DOI 10.1016/j.kjms.2012.04.027
   Watari K, 2008, J CLIN EXP NEUROPSYC, V30, P389, DOI 10.1080/13803390701440486
   Watari K, 2006, ARCH CLIN NEUROPSYCH, V21, P787, DOI 10.1016/j.acn.2006.06.014
   Wildes JE, 2006, J CLIN PSYCHIAT, V67, P904, DOI 10.4088/JCP.v67n0607
   WISE RA, 1989, ANNU REV PSYCHOL, V40, P191, DOI 10.1146/annurev.ps.40.020189.001203
   WOLF H, 1974, SCAND J CLIN LAB INV, V33, P1
   Won SJ, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-182
   Yaffe K, 2004, JAMA-J AM MED ASSOC, V292, P2237, DOI 10.1001/jama.292.18.2237
   Yamada K, 2003, J PHARMACOL SCI, V91, P267
   Yan Chun-mei, 2011, Zhonghua Yi Xue Za Zhi, V91, P3193
   Young KD, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0088785
   YOUNG SN, 1981, BRIT J PHARMACOL, V74, P695, DOI 10.1111/j.1476-5381.1981.tb10480.x
   Zhao B, 2013, J BIOL CHEM, V288, P15590, DOI 10.1074/jbc.M112.440784
   Zhao WQ, 2004, EUR J PHARMACOL, V490, P71, DOI 10.1016/j.ejphar.2004.02.045
   Zhou JX, 2013, BEHAV BRAIN FUNCT, V9, DOI 10.1186/1744-9081-9-34
   Zigova T, 1998, MOL CELL NEUROSCI, V11, P234, DOI 10.1006/mcne.1998.0684
   Zunszain PA, 2011, PROG NEURO-PSYCHOPH, V35, P722, DOI 10.1016/j.pnpbp.2010.04.011
NR 233
TC 52
Z9 55
U1 0
U2 20
PU BENTHAM SCIENCE PUBL
PI BUSUM
PA PO BOX 294, BUSUM, 1400 AG, NETHERLANDS
SN 1871-5273
EI 1996-3181
J9 CNS NEUROL DISORD-DR
JI CNS Neurol. Disord.-Drug Targets
PY 2014
VL 13
IS 10
BP 1693
EP 1707
PG 15
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA CA0GG
UT WOS:000348594400008
PM 25470395
DA 2025-06-11
ER

PT J
AU Da Ronch, C
   Canuto, A
   Volkert, J
   Massarenti, S
   Weber, K
   Dehoust, MC
   Nanni, MG
   Andreas, S
   Sehner, S
   Schulz, H
   Härter, M
   Grassi, L
AF Da Ronch, C.
   Canuto, A.
   Volkert, J.
   Massarenti, S.
   Weber, K.
   Dehoust, M. C.
   Nanni, M. G.
   Andreas, S.
   Sehner, S.
   Schulz, H.
   Haerter, M.
   Grassi, L.
TI Association of television viewing with mental health and mild cognitive
   impairment in the elderly in three European countries, data from the
   MentDis_ICF65+project
SO MENTAL HEALTH AND PHYSICAL ACTIVITY
LA English
DT Article
DE Elderly; Sedentary behaviour; Television; Mental health; Cognition;
   Europe
ID PHYSICAL-ACTIVITY QUESTIONNAIRE; TYPE-2 DIABETES-MELLITUS; METABOLIC
   SYNDROME; CARDIOVASCULAR-DISEASE; SEDENTARY BEHAVIOR; INACTIVITY
   PHYSIOLOGY; STATE-EXAMINATION; LIFE-STYLE; RISK; TIME
AB Background: Time spent watching TV by Europeans has been calculated to be 22.1 h per week on average and it has shown to be correlated with a series of physical and mental problems in adults. Very little research is available in population over 65. This study aimed at evaluating the association between TV viewing and mental disorders and cognitive performance, taking into account the general physical activity level and sodo-demographic characteristics in Europe.
   Methods: Within the MentDis_ICF65+ study, a subsample of 1383 subjects aged 65-84 years were assessed by the Composite International Diagnostic Interview (CIDI65+) and the International Physical Activity Questionnaire (IPAQ) for physical activity evaluation. Time spent in watching TV was assessed through a self report instrument.
   Results: Forty-three per cent of the total sample watched TV for 5-7 days a week for 2 or more hours every day. Females, people who lived alone, older subjects and those with lower education significantly watched TV for a longer time. Stepwise multiple regression showed statistically significant inverse correlation between Mini-Mental State Examination scores and TV viewing time (p < 0.001). Apart from a negative association-with Major Depressive Disorder, no particular associations were found between TV viewing and psychopathological diagnoses.
   Conclusions: Given the relationship of time spending watching TV with cognitive impairment, awareness should be raised about the possible negative effects of TV viewing on the elderly and programs to reduce TV viewing time should be set up. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Da Ronch, C.; Massarenti, S.; Nanni, M. G.; Grassi, L.] Dept Biomed & Specialty Surg Sci, Sect Psychiat, I-44121 Ferrara, Italy.
   [Canuto, A.; Weber, K.] Univ Hosp Geneva HUG, Dept Psychiat & Mental Hlth, Div Liaison Psychiat & Crisis Intervent, CH-1211 Geneva 14, Switzerland.
   [Volkert, J.; Dehoust, M. C.; Andreas, S.; Schulz, H.; Haerter, M.] Univ Med Ctr Hamburg Eppendorf, Dept Med Psychol, D-20246 Hamburg, Germany.
   [Andreas, S.] Alpen Adria Univ Klagenfurt, Inst Psychol, A-9020 Klagenfurt, Austria.
   [Sehner, S.] Univ Med Ctr Hamburg Eppendorf, Dept Biometry & Epidemiol, D-20246 Hamburg, Germany.
C3 University of Hamburg; University Medical Center Hamburg-Eppendorf;
   University of Klagenfurt; University of Hamburg; University Medical
   Center Hamburg-Eppendorf
RP Da Ronch, C (corresponding author), Dept Biomed & Specialty Surg Sci, Sect Psychiat, Via Fossato di Mortara 64-B, I-44121 Ferrara, Italy.
EM chiara.daronch@unife.it; alessandra.canuto@hcuge.ch; jvolkert@uke.de;
   sara.massarenti@unife.it; kerstin.weber@hcuge.ch; m.dehoust@uke.de;
   mariagiulia.nanni@unife.it; sandreas@uke.de; s.sehner@uke.de;
   schulz@uke.de; m.haerter@uke.de; luigi.grassi@unife.it
RI Volkert, Jana/ABE-3460-2020; Costanza, Alessandra/ABD-8231-2020
OI Harter, Martin/0000-0001-7443-9890; Nanni, Maria
   Giulia/0000-0002-1085-4339; GRASSI, Luigi/0000-0002-1050-4494; Volkert,
   Jana/0000-0003-1555-2599; Andreas, Sylke/0000-0002-1060-1411
FU European Commission within the 7th Framework Research Program of the EU
   [223105]
FX This study is funded by a grant from the European Commission (Grant No:
   223105) within the 7th Framework Research Program of the EU.
CR Andreas S, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-62
   [Anonymous], 2013, Mental Health and Physical Activity, V6, P55
   [Anonymous], INT J METHODS PSYCHI
   APA A.P. A., 2000, Diagnostic and statistical manual of mental disorders: DSM-IV, V4th
   Arredondo EM, 2013, MENT HEALTH PHYS ACT, V6, P3, DOI 10.1016/j.mhpa.2012.10.005
   Atkin AJ, 2012, ANN BEHAV MED, V43, P181, DOI 10.1007/s12160-011-9320-y
   Basner M, 2009, SLEEP, V32, P747, DOI 10.1093/sleep/32.6.747
   Bowman Shanthy A, 2006, Prev Chronic Dis, V3, pA38
   Chen Xiao-rong, 2012, Zhonghua Yu Fang Yi Xue Za Zhi, V46, P399
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   CRUM RM, 1993, JAMA-J AM MED ASSOC, V269, P2386, DOI 10.1001/jama.269.18.2386
   de Wit L, 2011, PSYCHIAT RES, V186, P239, DOI 10.1016/j.psychres.2010.07.003
   Dunstan DW, 2012, DIABETES RES CLIN PR, V97, P368, DOI 10.1016/j.diabres.2012.05.020
   Dunstan DW, 2005, DIABETOLOGIA, V48, P2254, DOI 10.1007/s00125-005-1963-4
   Ekelund U, 2006, PLOS MED, V3, P2449, DOI 10.1371/journal.pmed.0030488
   Fogel J, 2006, SOUTH MED J, V99, P226, DOI 10.1097/01.smj.0000198270.52240.93
   FOLSTEIN MF, 1975, J PSYCHIAT RES, V12, P189, DOI 10.1016/0022-3956(75)90026-6
   Fratiglioni L, 2004, LANCET NEUROL, V3, P343, DOI 10.1016/S1474-4422(04)00767-7
   Fung TT, 2000, AM J EPIDEMIOL, V152, P1171, DOI 10.1093/aje/152.12.1171
   Gao X, 2007, DIABETES CARE, V30, P694, DOI 10.2337/dc06-1835
   Grontved A, 2011, JAMA-J AM MED ASSOC, V305, P2448, DOI 10.1001/jama.2011.812
   Hallal PC, 2004, MED SCI SPORT EXER, V36, P556, DOI 10.1249/01.MSS.0000117161.66394.07
   Hamer M., 2013, MEDICINE AND SCIENCE
   Hamer M, 2013, BRAIN BEHAV IMMUN, V33, P29, DOI 10.1016/j.bbi.2013.05.001
   Hamer M, 2010, AM J PREV MED, V38, P375, DOI 10.1016/j.amepre.2009.12.030
   Hamilton MT, 2007, DIABETES, V56, P2655, DOI 10.2337/db07-0882
   Hamilton MT, 2008, CURR CARDIOVASC RISK, V2, P292, DOI 10.1007/s12170-008-0054-8
   Hamilton MT, 2004, EXERC SPORT SCI REV, V32, P161
   Haro JM, 2006, INT J METH PSYCH RES, V15, P167, DOI 10.1002/mpr.196
   Harvey JA, 2013, INT J ENV RES PUB HE, V10, P6645, DOI 10.3390/ijerph10126645
   Hu FB, 2003, JAMA-J AM MED ASSOC, V289, P1785, DOI 10.1001/jama.289.14.1785
   Hu FB, 2001, ARCH INTERN MED, V161, P1542, DOI 10.1001/archinte.161.12.1542
   IPAQ-Group T., 2005, GUID DAT PROC AN INT
   Jakes RW, 2003, EUR J CLIN NUTR, V57, P1089, DOI 10.1038/sj.ejcn.1601648
   Katzmarzyk PT, 2009, MED SCI SPORT EXER, V41, P998, DOI 10.1249/MSS.0b013e3181930355
   Kesse-Guyot E, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047831
   Kessler RC, 2004, INT J METH PSYCH RES, V13, P122, DOI 10.1002/mpr.169
   Kikuchi H, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-213
   Kronenberg F, 2000, ATHEROSCLEROSIS, V153, P433, DOI 10.1016/S0021-9150(00)00426-3
   Küster M, 2004, SPORTVERLETZ SPORTSC, V18, P90, DOI 10.1055/s-2004-812910
   Lindstrom HA, 2005, BRAIN COGNITION, V58, P157, DOI 10.1016/j.bandc.2004.09.020
   Lucas M, 2011, AM J EPIDEMIOL, V174, P1017, DOI 10.1093/aje/kwr218
   Marshall SJ, 2004, INT J OBESITY, V28, P1238, DOI 10.1038/sj.ijo.0802706
   Nationmaster, 2009, MED STAT TEL VIEW MO
   OCONNOR DW, 1989, PSYCHOL MED, V19, P771, DOI 10.1017/S0033291700024375
   Otten JJ, 2010, OBESITY, V18, P1273, DOI 10.1038/oby.2009.371
   Paillard-Borg S, 2012, J ALZHEIMERS DIS, V31, P835, DOI 10.3233/JAD-2012-120724
   Rundek T, 2006, NEUROLOGY, V66, P794, DOI 10.1212/01.wnl.0000209497.38834.d7
   Sanchez-Villegas A, 2008, MED SCI SPORT EXER, V40, P827, DOI 10.1249/MSS.0b013e31816348b9
   Sousa RM, 2010, INT J METH PSYCH RES, V19, P1, DOI 10.1002/mpr.299
   Sugiyama T, 2008, ANN BEHAV MED, V35, P245, DOI 10.1007/s12160-008-9017-z
   Sun F, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-449
   Teychenne M, 2008, PREV MED, V46, P397, DOI 10.1016/j.ypmed.2008.01.009
   Teychenne M, 2011, INT J BEHAV MED, V17, P246, DOI 10.1007/s12529-010-9075-z
   TOMBAUGH TN, 1992, J AM GERIATR SOC, V40, P922, DOI 10.1111/j.1532-5415.1992.tb01992.x
   Wang JYJ, 2006, NEUROLOGY, V66, P911, DOI 10.1212/01.wnl.0000192165.99963.2a
   Wijndaele K, 2009, EUR J CLIN NUTR, V63, P421, DOI 10.1038/sj.ejcn.1602944
   WITTCHEN HU, 1994, J PSYCHIAT RES, V28, P57, DOI 10.1016/0022-3956(94)90036-1
   WITTCHEN HU, 1991, BRIT J PSYCHIAT, V159, P645, DOI 10.1192/bjp.159.5.645
   World Health Organization, 2002, ICF Beginners Guide: Towards a common language for functioning, disability and health
NR 60
TC 22
Z9 25
U1 0
U2 35
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1755-2966
J9 MENT HEALTH PHYS ACT
JI Ment. Health Phys. Act.
PD MAR
PY 2015
VL 8
BP 8
EP 14
DI 10.1016/j.mhpa.2014.11.002
PG 7
WC Psychology, Clinical; Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA CL1YK
UT WOS:000356740600002
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Chen, YY
   Zhang, F
   Yan, YA
   Wang, SQ
   Zhang, L
   Yan, FP
AF Chen, Yuanyuan
   Zhang, Fu
   Yan, Yanan
   Wang, Shiquan
   Zhang, Le
   Yan, Fengping
TI Sudden Cardiac Death in Schizophrenia During Hospitalization: An
   Autopsy-Based Study
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE schizophrenia; hospitalization; sudden cardiac death; antipsychotic;
   autopsy
ID METABOLIC SYNDROME; CARDIOVASCULAR MORTALITY; ANTIPSYCHOTIC-DRUGS; LIFE
   EXPECTANCY; RISK
AB Schizophrenia is a severe mental disorder that is often comorbid with heart dysfunction and even sudden cardiac death (SCD). Clinical studies of SCD in schizophrenia have been largely reported, while there are limited autopsy studies that directly showed whole-scale information of such events. In this study, we present nine autopsy-based SCD cases in schizophrenia patients who died suddenly during hospitalization. Their medical records before and during hospitalization, and postmortem autopsy findings were summarized. These decedents had an average duration of schizophrenia for 6.83 +/- 3.75 years with a male/female ratio of 4:5. They were all on intermittent antipsychotics medication before hospitalization and died within 15 days after hospitalization. Seven of the nine cases (77.8%) died of organic heart diseases such as severe coronary artery atherosclerosis (n = 4), myocarditis (n = 1), cardiomyopathy (n = 1), and pulmonary thromboembolism (n = 1). Two cases remained unexplained after systemic autopsy and toxicological examinations. Postmortem autopsy identified hepatic steatosis (n = 6) and respiratory inflammation (n = 3) as the most common associate extra-cardiac lesions. Our data provided autopsy-based data of SCD cases in schizophrenia and highlighted an intensive care of such patients during hospitalization.
C1 [Chen, Yuanyuan; Yan, Yanan; Wang, Shiquan; Yan, Fengping] Gannan Med Univ, Sch Basic Med Sci, Dept Forens Med, Ganzhou, Peoples R China.
   [Chen, Yuanyuan; Yan, Yanan; Wang, Shiquan; Yan, Fengping] Gannan Med Univ, Key Lab Prevent & Treatment Cardiovasc & Cerebrova, Minist Educ, Ganzhou, Peoples R China.
   [Zhang, Fu] Publ Secur Bur, Criminal Technol Ctr Guangdong Prov, Guangzhou, Peoples R China.
   [Zhang, Le] Gannan Med Univ, Forens Ctr, Ganzhou, Peoples R China.
C3 Gannan Medical University; Gannan Medical University; Ministry of
   Education - China; Gannan Medical University
RP Yan, FP (corresponding author), Gannan Med Univ, Sch Basic Med Sci, Dept Forens Med, Ganzhou, Peoples R China.; Yan, FP (corresponding author), Gannan Med Univ, Key Lab Prevent & Treatment Cardiovasc & Cerebrova, Minist Educ, Ganzhou, Peoples R China.
EM tomjiangxi@163.com
RI yan, feng/JAX-8275-2023; Wang, Sui-Dong/E-6063-2013
FU Open Project of Key Laboratory of Forensic Pathology, Ministry of Public
   Security [GAFYBL201903]; Science and Technology Project of Jiangxi
   Provincial Department of Education [GJJ160979]; Research Project of
   Gannan Medical University [XN201924]; Open Project of Key Laboratory of
   Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases
   of Ministry of Education [XN201810]
FX This work was financially funded by the Open Project of Key Laboratory
   of Forensic Pathology, Ministry of Public Security (No. GAFYBL201903),
   the Science and Technology Project of Jiangxi Provincial Department of
   Education (No. GJJ160979), the Research Project of Gannan Medical
   University (No. XN201924), and Open Project of Key Laboratory of
   Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases
   of Ministry of Education (No. XN201810).
CR Aaroe ASK, 2022, NORD J PSYCHIAT, V76, P114, DOI 10.1080/08039488.2021.1939779
   Basso C, 2017, VIRCHOWS ARCH, V471, P691, DOI 10.1007/s00428-017-2221-0
   Bowker TJ, 2003, QJM-INT J MED, V96, P269, DOI 10.1093/qjmed/hcg038
   Challa F, 2021, BMC PSYCHIATRY, V21, DOI 10.1186/s12888-021-03631-2
   Christiansen SL, 2021, INT J LEGAL MED, V135, P1395, DOI 10.1007/s00414-021-02595-y
   Davidson M, 2002, J CLIN PSYCHIAT, V63, P5
   Dieset I, 2016, SCHIZOPHRENIA BULL, V42, P1316, DOI 10.1093/schbul/sbw028
   Enger C, 2004, J NERV MENT DIS, V192, P19, DOI 10.1097/01.nmd.0000105996.62105.07
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hartwig FP, 2017, JAMA PSYCHIAT, V74, P1226, DOI 10.1001/jamapsychiatry.2017.3191
   Hennekens CH, 2005, AM HEART J, V150, P1115, DOI 10.1016/j.ahj.2005.02.007
   Hjorthoj C, 2017, LANCET PSYCHIAT, V4, P295, DOI 10.1016/S2215-0366(17)30078-0
   Huertas-Vazquez A, 2013, HEART RHYTHM, V10, P994, DOI 10.1016/j.hrthm.2013.03.020
   Ifteni P, 2014, SCHIZOPHR RES, V155, P72, DOI 10.1016/j.schres.2014.03.011
   Ijaz S, 2018, BMC PSYCHIATRY, V18, DOI 10.1186/s12888-018-1848-y
   Laursen TM, 2012, CURR OPIN PSYCHIATR, V25, P83, DOI 10.1097/YCO.0b013e32835035ca
   Li KJ, 2018, CURR OPIN PSYCHIATR, V31, P169, DOI 10.1097/YCO.0000000000000403
   Li LL, 2018, SCHIZOPHR RES, V195, P258, DOI 10.1016/j.schres.2017.09.033
   Li XQ, 2021, WORLD J PSYCHIATR, V11, P736, DOI 10.5498/wjp.v11.i10.736
   Lieberman JA, 2005, NEW ENGL J MED, V353, P1209, DOI 10.1056/NEJMoa051688
   Markwerth P, 2021, INT J LEGAL MED, V135, P483, DOI 10.1007/s00414-020-02481-z
   McCreadie RG, 2003, BRIT J PSYCHIAT, V183, P534, DOI 10.1192/bjp.183.6.534
   McCutcheon RA, 2020, JAMA PSYCHIAT, V77, P201, DOI 10.1001/jamapsychiatry.2019.3360
   Mueser KT, 2004, LANCET, V363, P2063, DOI 10.1016/S0140-6736(04)16458-1
   Rajabi F, 2011, ASIAN J PSYCHIATR, V4, P218, DOI 10.1016/j.ajp.2011.05.006
   Ray WA, 2009, NEW ENGL J MED, V360, P225, DOI 10.1056/NEJMoa0806994
   Scorza CA, 2020, PSYCHOSOMATICS, V61, P864, DOI 10.1016/j.psym.2020.02.005
   Sun DM, 2019, AM J FOREN MED PATH, V40, P312, DOI 10.1097/PAF.0000000000000512
   Sweeting J, 2013, SCHIZOPHR RES, V150, P398, DOI 10.1016/j.schres.2013.08.029
   Tang CH, 2021, SCHIZOPHR RES, V237, P9, DOI 10.1016/j.schres.2021.08.015
   Uchida H, 2015, CAN J PSYCHIAT, V60, P203, DOI 10.1177/070674371506000501
   Veeneman RR, 2022, SCHIZOPHRENIA BULL, V48, P463, DOI 10.1093/schbul/sbab132
   Vohra J, 2020, HEART LUNG CIRC, V29, P1427, DOI 10.1016/j.hlc.2020.07.003
NR 33
TC 4
Z9 4
U1 1
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JUL 1
PY 2022
VL 13
AR 933025
DI 10.3389/fpsyt.2022.933025
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 3B5XZ
UT WOS:000828014700001
PM 35845458
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lounici, A
   Iacob, A
   Hongler, K
   Mölling, MA
   Drechsler, M
   Hersberger, L
   Sethi, S
   Lang, UE
   Liwinski, T
AF Lounici, Astrid
   Iacob, Ana
   Hongler, Katarzyna
   Moelling, Melina A.
   Drechsler, Maria
   Hersberger, Luca
   Sethi, Shebani
   Lang, Undine E.
   Liwinski, Timur
TI Ketogenic Diet as a Nutritional Metabolic Intervention for
   Obsessive-Compulsive Disorder: A Narrative Review
SO NUTRIENTS
LA English
DT Review
DE ketogenic diet; obsessive-compulsive disorder; metabolic syndrome;
   metabolic psychiatry; nutritional therapy
ID LOW-FAT DIET; GENERALIZED ANXIETY DISORDER; LOW-CARBOHYDRATE; OXIDATIVE
   STRESS; MITOCHONDRIAL DYSFUNCTION; CARDIOVASCULAR-DISEASES; PREFRONTAL
   CORTEX; BODY METABOLISM; MOOD DISORDERS; ADULT PATIENTS
AB The substantial evidence supporting the ketogenic diet (KD) in epilepsy management has spurred research into its effects on other neurological and psychiatric conditions. Despite differences in characteristics, symptoms, and underlying mechanisms, these conditions share common pathways that the KD may influence. The KD reverses metabolic dysfunction. Moreover, it has been shown to support neuroprotection through mechanisms such as neuronal energy support, inflammation reduction, amelioration of oxidative stress, and reversing mitochondrial dysfunction. The adequate intake of dietary nutrients is essential for maintaining normal brain functions, and strong evidence supports the role of nutrition in the treatment and prevention of many psychiatric and neurological disorders. Obsessive-compulsive disorder (OCD) is a neuropsychiatric condition marked by persistent, distressing thoughts or impulses (obsessions) and repetitive behaviors performed in response to these obsessions (compulsions). Recent studies have increasingly examined the role of nutrition and metabolic disorders in OCD. This narrative review examines current evidence on the potential role of the KD in the treatment of OCD. We explore research on the KD's effects on psychiatric disorders to assess its potential relevance for OCD treatment. Additionally, we identify key gaps in the preclinical and clinical research that warrant further study in applying the KD as a metabolic therapy for OCD.
C1 [Lounici, Astrid; Hongler, Katarzyna; Lang, Undine E.; Liwinski, Timur] Univ Basel, Univ Psychiat Clin Basel, Clin Adults, CH-4031 Basel, Switzerland.
   [Iacob, Ana] Hop Valais, Unite Psychiat Liaison, Pole Psychiat & Psychotherapie PPP, CH-1950 Sion, Switzerland.
   [Moelling, Melina A.] MEDIAN Zentrum Verhaltensmed, D-31812 Bad Pyrmont, Germany.
   [Drechsler, Maria; Hersberger, Luca] Klin SGM Langenthal, Stiftung Ganzheitl Med SGM, CH-4900 Langenthal, Switzerland.
   [Sethi, Shebani] Stanford Univ, Dept Psychiat & Behav Sci, Metab Psychiat, Sch Med, Palo Alto, CA 94305 USA.
C3 University of Basel; Stanford University
RP Liwinski, T (corresponding author), Univ Basel, Univ Psychiat Clin Basel, Clin Adults, CH-4031 Basel, Switzerland.
EM astrid.lounici@upk.ch; ana.iacob@hopitalvs.ch; katarzyna.hongler@upk.ch;
   melina.anastasia.moelling@gmail.com; maria.drechsler@klinik-sgm.ch;
   luca.hersberger@klinik-sgm.ch; shebanis@stanford.edu;
   undine.lang@upk.ch; timur.liwinski@upk.ch
RI Lang, Undine/K-5553-2015
OI Iacob, Ana/0009-0001-1079-4460; Sethi, Shebani/0000-0001-6938-2471
CR Abdin E, 2022, SINGAP MED J, V63, P196, DOI 10.11622/smedj.2020124
   Aboujaoude E, 2009, J CLIN PSYCHOPHARM, V29, P51, DOI 10.1097/JCP.0b013e318192e9a4
   Abramovitch A, 2013, CLIN PSYCHOL REV, V33, P1163, DOI 10.1016/j.cpr.2013.09.004
   Aguglia A, 2018, PSYCHIAT INVEST, V15, P246, DOI 10.30773/pi.2017.06.17.2
   Ahmari SE, 2022, NEUROPSYCHOPHARMACOL, V47, P211, DOI 10.1038/s41386-021-01130-2
   Albelda N, 2010, PSYCHOPHARMACOLOGY, V210, P13, DOI 10.1007/s00213-010-1808-9
   Alberry B, 2023, NEUROSCI BIOBEHAV R, V153, DOI 10.1016/j.neubiorev.2023.105350
   Albert U, 2013, GEN HOSP PSYCHIAT, V35, P154, DOI 10.1016/j.genhosppsych.2012.10.004
   Alberti K.G.M.M., Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention
   Alici D, 2016, PSYCHIAT CLIN NEUROS, V70, P109, DOI 10.1111/pcn.12362
   Alizadeh NS, 2018, IRAN J PSYCHIATRY BE, V12, DOI 10.5812/ijpbs.11611
   Andreazza AC, 2013, J NEUROCHEM, V127, P552, DOI 10.1111/jnc.12316
   Arnold PD, 2018, MOL PSYCHIATR, V23, P1181, DOI 10.1038/mp.2017.154
   Arumugham SS, 2013, EXPERT REV NEUROTHER, V13, P187, DOI [10.1586/ern.12.160, 10.1586/ERN.12.160]
   Astrup A, 2004, LANCET, V364, P897, DOI 10.1016/S0140-6736(04)16986-9
   Attwells S, 2017, JAMA PSYCHIAT, V74, P833, DOI 10.1001/jamapsychiatry.2017.1567
   Bandelow B, 2017, WORLD J BIOL PSYCHIA, V18, P162, DOI 10.1080/15622975.2016.1190867
   Beattie EC, 2000, NAT NEUROSCI, V3, P1291, DOI 10.1038/81823
   Bent-Ennakhil N, 2018, NORD J PSYCHIAT, V72, P455, DOI 10.1080/08039488.2018.1463392
   Beyazyüz M, 2013, PSYCHIAT INVEST, V10, P148, DOI 10.4306/pi.2013.10.2.148
   Bhattacharyya S, 2009, NEUROPSYCHOPHARMACOL, V34, P2489, DOI 10.1038/npp.2009.77
   Bloch MH, 2010, MOL PSYCHIATR, V15, P850, DOI 10.1038/mp.2009.50
   Bloch MH, 2012, BIOL PSYCHIAT, V72, P964, DOI 10.1016/j.biopsych.2012.05.028
   Bloch MH, 2008, AM J PSYCHIAT, V165, P1532, DOI 10.1176/appi.ajp.2008.08020320
   Boedhoe PSW, 2017, AM J PSYCHIAT, V174, P60, DOI 10.1176/appi.ajp.2016.16020201
   Bohnen JLB, 2023, NUTRIENTS, V15, DOI 10.3390/nu15133068
   Bostock ECS, 2017, FRONT PSYCHIATRY, V8, DOI 10.3389/fpsyt.2017.00043
   Brakoulias V, 2017, COMPR PSYCHIAT, V76, P79, DOI 10.1016/j.comppsych.2017.04.002
   Bralten J, 2020, TRANSL PSYCHIAT, V10, DOI 10.1038/s41398-020-0793-y
   Brander G, 2016, NEUROSCI BIOBEHAV R, V65, P36, DOI 10.1016/j.neubiorev.2016.03.011
   Brennan BP, 2013, BIOL PSYCHIAT, V73, P24, DOI 10.1016/j.biopsych.2012.06.023
   Bruin WB, 2020, TRANSL PSYCHIAT, V10, DOI 10.1038/s41398-020-01013-y
   Campbell IH, 2024, medRxiv, DOI [10.1101/2023.10.23.23297391, 10.1101/2023.10.23.23297391, DOI 10.1101/2023.10.23.23297391]
   Carroll D, 2009, BIOL PSYCHIAT, V66, P91, DOI 10.1016/j.biopsych.2009.02.020
   Carter CS, 1998, SCIENCE, V280, P747, DOI 10.1126/science.280.5364.747
   Chakrabarty K, 2005, NEUROPSYCHOPHARMACOL, V30, P1735, DOI 10.1038/sj.npp.1300733
   Chamberlain SR, 2019, AUST NZ J PSYCHIAT, V53, P896, DOI 10.1177/0004867419844325
   Chiu SL, 2008, NEURON, V58, P708, DOI 10.1016/j.neuron.2008.04.014
   Chiu SL, 2010, NEURAL DEV, V5, DOI 10.1186/1749-8104-5-7
   Cole MW, 2007, NEUROIMAGE, V37, P343, DOI 10.1016/j.neuroimage.2007.03.071
   Coric V, 2005, BIOL PSYCHIAT, V58, P424, DOI 10.1016/j.biopsych.2005.04.043
   Cox RC, 2020, CURR OPIN PSYCHOL, V34, P23, DOI 10.1016/j.copsyc.2019.08.018
   Cunnane SC, 2003, COMP BIOCHEM PHYS A, V136, P17, DOI 10.1016/S1095-6433(03)00048-5
   Dalgleish T, 2020, J CONSULT CLIN PSYCH, V88, P179, DOI 10.1037/ccp0000482
   Danan A, 2022, FRONT PSYCHIATRY, V13, DOI 10.3389/fpsyt.2022.951376
   Decloedt EH, 2010, NEUROPSYCH DIS TREAT, V6, P233
   Del Caño R, 2023, TRAC-TREND ANAL CHEM, V159, DOI 10.1016/j.trac.2023.116938
   Denys D, 2006, PSYCHIAT CLIN N AM, V29, P553, DOI 10.1016/j.psc.2006.02.013
   Dèttore D, 2015, COGN BEHAV THERAPY, V44, P190, DOI 10.1080/16506073.2015.1005660
   Dold M, 2015, INT J NEUROPSYCHOPH, V18, DOI 10.1093/ijnp/pyv047
   dos Santos MAB, 2014, REV BRAS PSIQUIATR, V36, P298, DOI 10.1590/1516-4446-2013-1230
   Dou JT, 2005, LEARN MEMORY, V12, P646, DOI 10.1101/lm.88005
   Dykshoorn KL, 2014, HEALTH PSYCHOL BEHAV, V2, P517, DOI 10.1080/21642850.2014.905207
   Egashira N, 2008, EUR J PHARMACOL, V586, P164, DOI 10.1016/j.ejphar.2008.01.035
   El-Rashidy O, 2017, METAB BRAIN DIS, V32, P1935, DOI 10.1007/s11011-017-0088-z
   Espinós C, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9040313
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   Faravelli C, 2012, WORLD J PSYCHIATR, V2, P13, DOI 10.5498/wjp.v2.i1.13
   Fattal O, 2006, PSYCHOSOMATICS, V47, P1, DOI 10.1176/appi.psy.47.1.1
   Fattal O, 2007, CNS SPECTRUMS, V12, P429, DOI 10.1017/S1092852900015303
   Fawcett EJ, 2020, J CLIN PSYCHIAT, V81, DOI 10.4088/JCP.19r13085
   Ference BA, 2012, J AM COLL CARDIOL, V60, P2631, DOI 10.1016/j.jacc.2012.09.017
   Feusner JD, 2009, PSYCHOPHARMACOL BULL, V42, P81
   Fineberg NA, 2003, J CLIN PSYCHIAT, V64, P152, DOI 10.4088/JCP.v64n0207
   Foa EB, 2005, AM J PSYCHIAT, V162, P151, DOI 10.1176/appi.ajp.162.1.151
   Fontenelle LF, 2012, COMPR PSYCHIAT, V53, P797, DOI 10.1016/j.comppsych.2011.12.007
   Fontenelle LF, 2006, PROG NEURO-PSYCHOPH, V30, P327, DOI 10.1016/j.pnpbp.2005.11.001
   Foster GD, 2003, NEW ENGL J MED, V348, P2082, DOI 10.1056/NEJMoa022207
   Fukao T, 2004, PROSTAG LEUKOTR ESS, V70, P243, DOI 10.1016/j.plefa.2003.11.001
   Fusar-Poli P, 2019, WORLD PSYCHIATRY, V18, P192, DOI 10.1002/wps.20631
   Gao M, 2024, J PSYCHIATR RES, V174, P230, DOI 10.1016/j.jpsychires.2024.04.023
   Gheshlagh RG, 2016, IRAN RED CRESCENT ME, V18, DOI 10.5812/ircmj.26523
   Giordano C, 2014, FRONT NEUROL, V5, DOI 10.3389/fneur.2014.00063
   Grant P, 2007, J CHILD ADOL PSYCHOP, V17, P761, DOI 10.1089/cap.2007.0021
   Grassi G, 2022, CNS SPECTRUMS, V27, P421, DOI 10.1017/S1092852921000122
   Gray SM, 2012, CURR PSYCHIAT REP, V14, P220, DOI 10.1007/s11920-012-0272-0
   Gürsel DA, 2018, NEUROSCI BIOBEHAV R, V87, P151, DOI 10.1016/j.neubiorev.2018.01.016
   Guevara-Cruz M, 2024, CLIN NUTR, V43, P1914, DOI 10.1016/j.clnu.2024.06.036
   Gutiérrez-Repiso C, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201900167
   Haces ML, 2008, EXP NEUROL, V211, P85, DOI 10.1016/j.expneurol.2007.12.029
   Harun-Or-Rashid M, 2018, J NEUROINFLAMM, V15, DOI 10.1186/s12974-018-1346-7
   Hasan-Olive MM, 2019, NEUROCHEM RES, V44, P22, DOI 10.1007/s11064-018-2588-6
   Hathy E, 2020, STEM CELL RES THER, V11, DOI 10.1186/s13287-020-01980-5
   Hengist A, 2024, CELL REP MED, V5, DOI 10.1016/j.xcrm.2024.101667
   Hezel DM, 2019, INDIAN J PSYCHIAT, V61, pS85, DOI 10.4103/psychiatry.IndianJPsychiatry_516_18
   HOEHNSARIC R, 1993, J CLIN PSYCHIAT, V54, P272
   Hughes SD, 2014, J NEUROCHEM, V129, P426, DOI 10.1111/jnc.12646
   Hunsley J, 2014, CAN PSYCHOL, V55, P161, DOI 10.1037/a0036933
   ICD, 2019, ICD-10
   INSEL TR, 1985, BIOL PSYCHIAT, V20, P1174, DOI 10.1016/0006-3223(85)90176-3
   Isomura K, 2021, J PSYCHIATR RES, V135, P189, DOI 10.1016/j.jpsychires.2020.12.066
   Isomura K, 2018, BIOL PSYCHIAT, V84, P324, DOI 10.1016/j.biopsych.2017.12.003
   Jensen NJ, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21228767
   Jeon BT, 2009, NEUROSCI LETT, V453, P49, DOI 10.1016/j.neulet.2009.01.068
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   Kakani G., 2022, Princ Pract Clin Res, V8, P77, DOI [10.21801/ppcrj.2022.83.10, DOI 10.21801/PPCRJ.2022.83.10]
   Kaplan Peter W, 2010, Dialogues Clin Neurosci, V12, P241
   Kariuki-Nyuthe C, 2014, CURR OPIN PSYCHIATR, V27, P32, DOI 10.1097/YCO.0000000000000017
   Kathmann N, 2022, PSYCHOTHER PSYCHOSOM, DOI 10.1159/000520454
   Kaur Ramandeep, 2023, Ind Psychiatry J, V32, P130, DOI 10.4103/ipj.ipj_22_22
   Kessler RC, 2012, INT J METH PSYCH RES, V21, P169, DOI 10.1002/mpr.1359
   Khalkhali M, 2023, FRONT PSYCHIATRY, V14, DOI 10.3389/fpsyt.2023.1164750
   Kim E, 2016, PSYCHOL MED, V46, P357, DOI 10.1017/S0033291715001865
   Kim JH, 2006, J ENDOCRINOL, V191, P437, DOI 10.1677/joe.1.06647
   Kishi T, 2022, TRANSL PSYCHIAT, V12, DOI 10.1038/s41398-022-02026-5
   Kontoangelos K, 2013, INT J PSYCHIAT CLIN, V17, P48, DOI 10.3109/13651501.2012.697563
   Koran LM, 2007, AM J PSYCHIAT, V164, P5
   Kraeuter AK, 2020, METHODS MOL BIOL, V2138, P83, DOI 10.1007/978-1-0716-0471-7_4
   Kullmann S, 2020, LANCET DIABETES ENDO, V8, P524, DOI 10.1016/S2213-8587(20)30113-3
   Kullmann S, 2016, PHYSIOL REV, V96, P1169, DOI 10.1152/physrev.00032.2015
   Labad J, 2021, J PSYCHIATR RES, V133, P191, DOI 10.1016/j.jpsychires.2020.12.017
   Lambadiari V, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25052475
   Leboyer M, 2022, J AFFECT DISORDERS, V307, P149, DOI 10.1016/j.jad.2022.03.053
   Leckman JE, 2010, DEPRESS ANXIETY, V27, P507, DOI 10.1002/da.20669
   Lee CC, 2011, NEUROPHARMACOLOGY, V61, P867, DOI 10.1016/j.neuropharm.2011.06.003
   Lee PH, 2019, CELL, V179, P1469, DOI 10.1016/j.cell.2019.11.020
   Lee RWY, 2018, PHYSIOL BEHAV, V188, P205, DOI 10.1016/j.physbeh.2018.02.006
   Lensi P, 1996, BRIT J PSYCHIAT, V169, P101, DOI 10.1192/bjp.169.1.101
   Li Z, 2004, CELL, V119, P873, DOI 10.1016/j.cell.2004.11.003
   Liberopoulos EN, 2005, OBES REV, V6, P283, DOI 10.1111/j.1467-789X.2005.00221.x
   Liu CH, 2020, J AGR FOOD CHEM, V68, P11215, DOI 10.1021/acs.jafc.0c04604
   Lloyd CE, 2018, DIABETIC MED, V35, P760, DOI 10.1111/dme.13611
   Longhitano C, 2024, FRONT NUTR, V11, DOI 10.3389/fnut.2024.1444483
   López-Doménech G, 2016, CELL REP, V17, P317, DOI 10.1016/j.celrep.2016.09.004
   Ludwig DS, 2020, J NUTR, V150, P1354, DOI 10.1093/jn/nxz308
   Ludwig DS, 2018, SCIENCE, V362, P764, DOI 10.1126/science.aau2096
   Luong TV, 2024, DIABETES, V73, DOI 10.2337/db24-0162
   Mahjani B, 2021, PSYCHOL MED, V51, P2247, DOI 10.1017/S0033291721001744
   Marcus SC, 2015, J MANAG CARE SPEC PH, V21, P754, DOI 10.18553/jmcp.2015.21.9.754
   Marosi K, 2016, J NEUROCHEM, V139, P769, DOI 10.1111/jnc.13868
   Martin-McGill KJ, 2018, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001903.pub4
   Martínez-González MA, 2015, PROG CARDIOVASC DIS, V58, P50, DOI 10.1016/j.pcad.2015.04.003
   MARTINOT JL, 1990, AM J PSYCHIAT, V147, P1313
   Masood W., 2023, StatPearls Internet
   Mataix-Cols D, 2018, MOL PSYCHIATR, V23, P1652, DOI 10.1038/mp.2017.215
   Mataix-Cols D, 2005, AM J PSYCHIAT, V162, P228, DOI 10.1176/appi.ajp.162.2.228
   Mataix-Cols D, 2013, JAMA PSYCHIAT, V70, P709, DOI 10.1001/jamapsychiatry.2013.3
   McClernon FJ, 2007, OBESITY, V15, P182, DOI 10.1038/oby.2007.516
   McGrath LM, 2014, J AM ACAD CHILD PSY, V53, P910, DOI 10.1016/j.jaac.2014.04.022
   Mendoza E, 2014, NEUROSCIENCE, V280, P156, DOI 10.1016/j.neuroscience.2014.09.018
   Merovci A, 2024, BMJ OPEN DIAB RES CA, V12, DOI 10.1136/bmjdrc-2024-004199
   Milder J, 2012, EPILEPSY RES, V100, P295, DOI 10.1016/j.eplepsyres.2011.09.021
   Miller EK, 2000, NAT REV NEUROSCI, V1, P59, DOI 10.1038/35036228
   Miller ML, 2017, J ANXIETY DISORD, V47, P29, DOI 10.1016/j.janxdis.2017.02.005
   MINK JW, 1981, AM J PHYSIOL, V241, pR203, DOI 10.1152/ajpregu.1981.241.3.R203
   MITCHELL GA, 1995, CLIN INVEST MED, V18, P193
   Morris G, 2020, INT J NEUROPSYCHOPH, V23, P366, DOI 10.1093/ijnp/pyaa008
   Mujica-Parodi LR, 2020, P NATL ACAD SCI USA, V117, P6170, DOI 10.1073/pnas.1913042117
   Murphy ML, 2002, ARCH PEDIAT ADOL MED, V156, P356, DOI 10.1001/archpedi.156.4.356
   Murphy P, 2004, BIOL PSYCHIAT, V56, P981, DOI 10.1016/j.biopsych.2004.09.019
   Nakamura K, 2022, NUTRIENTS, V14, DOI 10.3390/nu14061199
   Needham N, 2023, BJPSYCH OPEN, V9, DOI 10.1192/bjo.2023.568
   Nguyen TTL, 2018, NEUROSCI BIOBEHAV R, V92, P7, DOI 10.1016/j.neubiorev.2018.05.014
   Nikolaus S, 2010, REV NEUROSCIENCE, V21, P119
   Norman LJ, 2021, AM J PSYCHIAT, V178, P39, DOI 10.1176/appi.ajp.2020.19080886
   Norwitz NG, 2020, CURR OPIN ENDOCRINOL, V27, P269, DOI 10.1097/MED.0000000000000564
   NOSHIRVANI HF, 1991, BRIT J PSYCHIAT, V158, P260, DOI 10.1192/bjp.158.2.260
   Osete JR, 2021, MOL PSYCHIATR, V26, P6789, DOI 10.1038/s41380-021-01164-4
   Pallanti Stefano, 2011, Front Psychiatry, V2, P70, DOI 10.3389/fpsyt.2011.00070
   Paoli A, 2015, FRONT PSYCHOL, V6, DOI 10.3389/fpsyg.2015.00027
   Pardossi S, 2024, J CLIN MED, V13, DOI 10.3390/jcm13164739
   Patel M, 2004, FREE RADICAL BIO MED, V37, P1951, DOI 10.1016/j.freeradbiomed.2004.08.021
   Patikorn C, 2023, BMC MED, V21, DOI 10.1186/s12916-023-02874-y
   PAULS DL, 1995, AM J PSYCHIAT, V152, P76
   Paulweber B, 2010, HORM METAB RES, V42, pS3, DOI 10.1055/s-0029-1240928
   Pellegrini L, 2020, J AFFECT DISORDERS, V276, P1001, DOI 10.1016/j.jad.2020.07.115
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Phadnis Pradeep, 2018, Journal of Basic and Clinical Physiology and Pharmacology, V29, P421, DOI 10.1515/jbcpp-2017-0155
   Pillinger T, 2023, LANCET PSYCHIAT, V10, P860, DOI 10.1016/S2215-0366(23)00262-6
   Pillinger T, 2020, LANCET PSYCHIAT, V7, P64, DOI 10.1016/S2215-0366(19)30416-X
   Pinsawas B, 2024, J NUTR, V154, P3331, DOI 10.1016/j.tjnut.2024.08.027
   Rao NP, 2015, PSYCHIAT RES, V229, P949, DOI 10.1016/j.psychres.2015.07.009
   RASMUSSEN SA, 1988, PSYCHOPHARMACOL BULL, V24, P466
   Robbins TW, 2019, NEURON, V102, P27, DOI 10.1016/j.neuron.2019.01.046
   Rodriguez CI, 2013, NEUROPSYCHOPHARMACOL, V38, P2475, DOI 10.1038/npp.2013.150
   Rodríguez N, 2017, J NEUROINFLAMM, V14, DOI 10.1186/s12974-017-1042-z
   Roefs A, 2022, BEHAV RES THER, V153, DOI 10.1016/j.brat.2022.104096
   Rosario-Campos MC, 2006, MOL PSYCHIATR, V11, P495, DOI 10.1038/sj.mp.4001798
   Ruscio AM, 2010, MOL PSYCHIATR, V15, P53, DOI 10.1038/mp.2008.94
   Russell EJ, 2013, J CLIN PSYCHIAT, V74, P377, DOI 10.4088/JCP.12r07917
   Samaha FF, 2003, NEW ENGL J MED, V348, P2074, DOI 10.1056/NEJMoa022637
   Nunes AKS, 2015, BRAIN RES, V1627, P119, DOI 10.1016/j.brainres.2015.09.008
   Sarris J, 2015, LANCET PSYCHIAT, V2, P271, DOI 10.1016/S2215-0366(14)00051-0
   Schaefer AM, 2004, BBA-BIOENERGETICS, V1659, P115, DOI 10.1016/j.bbabio.2004.09.005
   Schulmann Anton, 2019, Mol Neuropsychiatry, V5, P13, DOI 10.1159/000495658
   Sethi S, 2024, PSYCHIAT RES, V335, DOI 10.1016/j.psychres.2024.115866
   Sethi Shebani, 2022, J Psychiatr Brain Sci, V7, DOI 10.20900/jpbs.20220009
   Shai I, 2008, NEW ENGL J MED, V359, P229, DOI 10.1056/NEJMoa0708681
   Shamabadi A, 2024, PSYCHIAT CLIN NEUROS, V78, P810, DOI 10.1111/pcn.13748
   Shamshtein D., 2022, Recent Progress in Nutrition, V2, P1, DOI DOI 10.21926/RPN.2201003
   Sharma E, 2019, INDIAN J PSYCHIAT, V61, pS43, DOI 10.4103/psychiatry.IndianJPsychiatry_521_18
   Shorter E., 2021, The rise and fall of the age of psychopharmacology, P305
   Simsek S, 2016, INT J NEUROPSYCHOPH, V19, DOI 10.1093/ijnp/pyw027
   Singh RK, 2017, J TRANSL MED, V15, DOI 10.1186/s12967-017-1175-y
   Skapinakis P, 2016, LANCET PSYCHIAT, V3, P730, DOI 10.1016/S2215-0366(16)30069-4
   Sofi F, 2010, AM J CLIN NUTR, V92, P1189, DOI 10.3945/ajcn.2010.29673
   Soomro GM, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001765.pub3
   Stahl Eli A, 2019, Nat Genet, V51, P793, DOI 10.1038/s41588-019-0397-8
   Stein DJ, 2019, NAT REV DIS PRIMERS, V5, DOI 10.1038/s41572-019-0102-3
   Stengler-Wenzke K, 2004, FORTSCHR NEUROL PSYC, V72, P7
   Stewart SE, 2013, AM J MED GENET B, V162B, P367, DOI 10.1002/ajmg.b.32137
   Strassnig M, 2017, BIPOLAR DISORD, V19, P336, DOI 10.1111/bdi.12505
   Subramaniam M, 2020, ANN ACAD MED SINGAP, V49, P15
   Sukkar SG, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.642628
   Swick D, 2002, P NATL ACAD SCI USA, V99, P16354, DOI 10.1073/pnas.252521499
   Taylor S, 2013, MOL PSYCHIATR, V18, P799, DOI 10.1038/mp.2012.76
   Torres A.R., 2017, Epidemiology, comorbidity, and burden of OCD. Obsessivecompulsive disorder: phenomenology, pathophysiology, VVolume 1
   Tsai CH, 2012, J PSYCHIATR RES, V46, P927, DOI 10.1016/j.jpsychires.2012.04.003
   Tsuyama T, 2017, J CELL BIOL, V216, P815, DOI 10.1083/jcb.201604065
   Turna J, 2020, ACTA PSYCHIAT SCAND, V142, P337, DOI 10.1111/acps.13175
   Uranova NA, 2021, ASIAN J PSYCHIATR, V63, DOI 10.1016/j.ajp.2021.102752
   Valenciano AI, 2006, J NEUROCHEM, V99, P524, DOI 10.1111/j.1471-4159.2006.04043.x
   Vallée A, 2022, MOL PSYCHIATR, V27, P230, DOI 10.1038/s41380-021-01086-1
   Vallée A, 2021, TRANSL PSYCHIAT, V11, DOI 10.1038/s41398-021-01329-3
   van de Vondervoort IIGM, 2019, TRANSL PSYCHIAT, V9, DOI 10.1038/s41398-019-0559-6
   van der Louw E, 2016, EUR J PAEDIATR NEURO, V20, P798, DOI 10.1016/j.ejpn.2016.07.009
   Veale D, 2014, BMJ-BRIT MED J, V348, DOI 10.1136/bmj.g2183
   Virtanen S, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2022.14779
   Voderholzer U., 2022, S3-Leitlinie Zwangsstorungen-Langversion Revision im
   Wan Q, 1997, NATURE, V388, P686, DOI 10.1038/41792
   Wang ZJ, 2021, NPJ SCHIZOPHR, V7, DOI 10.1038/s41537-021-00159-y
   Watanabe M, 2020, OBES REV, V21, DOI 10.1111/obr.13024
   Weiss AP, 2000, J NEUROPSYCH CLIN N, V12, P265, DOI 10.1176/appi.neuropsych.12.2.265
   Wheless JW, 2008, EPILEPSIA, V49, P3, DOI 10.1111/j.1528-1167.2008.01821.x
   Wise SP, 1996, CRIT REV NEUROBIOL, V10, P317, DOI 10.1615/CritRevNeurobiol.v10.i3-4.30
   Witthauer C, 2014, SOC PSYCH PSYCH EPID, V49, P2013, DOI 10.1007/s00127-014-0895-z
   Wray NR, 2018, NAT GENET, V50, P668, DOI 10.1038/s41588-018-0090-3
   Wu M, 2012, PHARMACOL BIOCHEM BE, V100, P726, DOI 10.1016/j.pbb.2011.10.007
   Yancy WS, 2004, ANN INTERN MED, V140, P769, DOI 10.7326/0003-4819-140-10-200405180-00006
   Youm YH, 2015, NAT MED, V21, P263, DOI 10.1038/nm.3804
   Yudkoff M, 2005, NEUROCHEM INT, V47, P119, DOI 10.1016/j.neuint.2005.04.014
   Yudkoff M, 1997, J NEUROCHEM, V69, P682
   Yudkoff M, 2008, EPILEPSIA, V49, P73, DOI 10.1111/j.1528-1167.2008.01841.x
   Zarnowska I, 2018, METAB BRAIN DIS, V33, P1187, DOI 10.1007/s11011-018-0219-1
   Zhang BW, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.674568
   Zhao WQ, 1999, J BIOL CHEM, V274, P34893, DOI 10.1074/jbc.274.49.34893
   Ziegler S, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0261169
NR 237
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2025
VL 17
IS 1
AR 31
DI 10.3390/nu17010031
PG 25
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA R8G6F
UT WOS:001393767700001
PM 39796465
OA gold
DA 2025-06-11
ER

PT J
AU Corazza, DI
   Sebastiao, É
   Pedroso, RV
   Andreatto, CAA
   Coelho, FGD
   Gobbi, S
   Teodorov, E
   Santos-Galduróz, RF
AF Corazza, Danilla Icassatti
   Sebastiao, Emerson
   Pedroso, Renata Valle
   Almeida Andreatto, Carla Andreza
   de Melo Coelho, Flavia Gomes
   Gobbi, Sebastiao
   Teodorov, Elizabeth
   Santos-Galduroz, Ruth Ferreira
TI Influence of chronic exercise on serum cortisol levels in older adults
SO EUROPEAN REVIEW OF AGING AND PHYSICAL ACTIVITY
LA English
DT Review
DE Cortisol; Exercise; Aging; Older people; Stress
ID HORMONAL RESPONSE PATTERNS; CHRONIC STRESS; RESISTANCE EXERCISE;
   METABOLIC SYNDROME; MUSCLE STRENGTH; MEN; WOMEN; ADAPTATIONS;
   NEUROENDOCRINE; DEPRESSION
AB The circulating level of cortisol is regulated by the hypothalamic-pituitary-adrenal axis through a neuroendocrine feedback circuit. This circuit can be activated by physiological stimuli such as stress, diseases, and exercise. High levels of serum cortisol hormone normally occur as a byproduct of aging, and can cause several types of damage to the organism and exacerbate immunosenescence. There is a great deal of variability in the cortisol response with regard to type, intensity, volume, and frequency of exercise. However, these relationships have been extensively studied with respect to the acute effects of exercise. Despite the well-known effects of acute exercise on cortisol response, it is unclear how it is affected by chronic exercise and the aging process. Therefore, the aim of this study was to conduct a review of studies that attempt to analyze the influence of chronic exercise on serum cortisol hormone in older people. In order to accomplish this goal, a review from 1970 to June 2012 period was performed using the following databases: Biological Abstracts, PsycINFO, PubMed/Medline, and the Web of Science. Eight articles met the criteria used in this study. Based on the included articles, chronic exercise may influence the serum levels of cortisol levels in older people. Despite this evidence, these results may not be generalized to the entire population of older people, given the few number of studies and especially because the studies showed diversity in variables and methodologies.
C1 [Corazza, Danilla Icassatti; Pedroso, Renata Valle; Almeida Andreatto, Carla Andreza; de Melo Coelho, Flavia Gomes; Gobbi, Sebastiao] UNESP Univ Estadual Paulista, Inst Biosci, Dept Phys Educ, Phys Act & Aging Lab LAFE, BR-13506900 Sao Paulo, Brazil.
   [Sebastiao, Emerson] Univ Illinois, Dept Kinesiol & Community Hlth, Urbana, IL 61801 USA.
   [Sebastiao, Emerson] Univ Illinois, Aging & Divers Lab ADL, Urbana, IL 61801 USA.
   [Teodorov, Elizabeth; Santos-Galduroz, Ruth Ferreira] Univ Fed ABC, Ctr Math Comp & Cognit, BR-09715000 Sao Paulo, Brazil.
C3 Universidade Estadual Paulista; University of Illinois System;
   University of Illinois Urbana-Champaign; University of Illinois System;
   University of Illinois Urbana-Champaign; Universidade Federal do ABC
   (UFABC)
RP Corazza, DI (corresponding author), UNESP Univ Estadual Paulista, Inst Biosci, Dept Phys Educ, Phys Act & Aging Lab LAFE, Ave 24 A,1515 Bela Vista, BR-13506900 Sao Paulo, Brazil.
EM danillacorazza@gmail.com; esebast2@illinois.edu; re.pedroso@hotmail.com;
   carla_andreatto@yahoo.com.br; flaviaeduca@yahoo.com.br;
   sgobbi@rc.unesp.br; elizabeth.teodorov@ufabc.edu.br;
   ruthfsantos@gmail.com
RI Santos-Galduróz, Ruth/B-8556-2012; Sebastiao, Emerson/ABF-7353-2020; de
   Almeida Andreatto, Carla/AAT-7075-2020; Pedroso, Renata/M-3535-2017
OI Pedroso, Renata/0000-0002-3583-2566; de Almeida Andreatto, Carla
   Andreza/0000-0002-0413-4108
FU FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo)
   [2011/07374-8]; CAPES (Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior); Swedish Research Council [2011-07374] Funding Source:
   Swedish Research Council; Fundacao de Amparo a Pesquisa do Estado de Sao
   Paulo (FAPESP) [11/07374-8] Funding Source: FAPESP
FX The authors would like to acknowledge LAFE (Laboratorio de Atividade
   Fisica e Envelhecimento) and Prof. Rodrigo Dalia (Laboratorio de
   Fisiologia Experimental) from Departamento de Educacao
   Fisica-Universidade Estadual Paulista (UNESP-Rio Claro/SP); Prof. Peter
   Fitschen (Exercise & Cardiovascular Research Laboratory) from the
   Department of Kinesiology and Community Health, University of Illinois
   at Urbana-Champaign; and financial support from FAPESP (Fundacao de
   Amparo a Pesquisa do Estado de Sao Paulo, Process n. 2011/07374-8) and
   CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior).
CR Andersen H, 2004, DIABETES, V53, P1543, DOI 10.2337/diabetes.53.6.1543
   Andrew R, 2002, EXP CLIN ENDOCR DIAB, V110, P284, DOI 10.1055/s-2002-34591
   Arnaldi G, 2003, J CLIN ENDOCR METAB, V88, P5593, DOI 10.1210/jc.2003-030871
   Bauer ME, 2009, ANN NY ACAD SCI, V1153, P139, DOI 10.1111/j.1749-6632.2008.03966.x
   Blumenthal JA, 1999, ARCH INTERN MED, V159, P2349, DOI 10.1001/archinte.159.19.2349
   Canali ES, 2005, REV PAUL ED FISICA, V15, P141
   CASPERSEN CJ, 1985, PUBLIC HEALTH REP, V100, P126
   Charmandari E, 2005, ANNU REV PHYSIOL, V67, P259, DOI 10.1146/annurev.physiol.67.040403.120816
   Checkley S, 1996, BRIT MED BULL, V52, P597
   Contarteze Ricardo Vinicius Ledesma, 2007, Rev Bras Med Esporte, V13, P169
   Crewther B, 2006, SPORTS MED, V36, P215, DOI 10.2165/00007256-200636030-00004
   Vale RGD, 2009, ARCH GERONTOL GERIAT, V49, P343, DOI 10.1016/j.archger.2008.11.011
   DELBENDE C, 1992, BRIT J PSYCHIAT, V160, P24, DOI 10.1192/S0007125000296657
   Duclos M, 2005, OBES RES, V13, P1157, DOI 10.1038/oby.2005.137
   França Sheyla Carla A., 2006, Arq Bras Endocrinol Metab, V50, P1082, DOI 10.1590/S0004-27302006000600015
   Garcia MC, 2008, ANN NY ACAD SCI, V1148, P504, DOI 10.1196/annals.1410.065
   Gibney J, 2007, ENDOCR REV, V28, P603, DOI 10.1210/er.2006-0052
   Goldspink G, 1992, STRENGTH POWER SPORT, P221
   Gotovac K, 2003, CLIN EXP IMMUNOL, V131, P335, DOI 10.1046/j.1365-2249.2003.02075.x
   Häkkinen K, 2002, CAN J APPL PHYSIOL, V27, P213
   Häkkinen K, 2001, J APPL PHYSIOL, V91, P569, DOI 10.1152/jappl.2001.91.2.569
   Häkkinen K, 2000, J GERONTOL A-BIOL, V55, pB95, DOI 10.1093/gerona/55.2.b95
   Ibáñez J, 2008, J DIABETES COMPLICAT, V22, P112, DOI 10.1016/j.jdiacomp.2007.06.008
   Izquierdo M, 2003, J STRENGTH COND RES, V17, P129
   Izquierdo M, 2001, J APPL PHYSIOL, V90, P1497, DOI 10.1152/jappl.2001.90.4.1497
   Keizer H.A., 1998, Overtraining in Sport, P145
   Kiecolt-Glaser JK, 2003, P NATL ACAD SCI USA, V100, P9090, DOI 10.1073/pnas.1531903100
   Kraemer WJ, 1998, EUR J APPL PHYSIOL O, V77, P206, DOI 10.1007/s004210050323
   Kraemer WJ, 1999, J APPL PHYSIOL, V87, P982, DOI 10.1152/jappl.1999.87.3.982
   Kraemer WJ, 2005, SPORTS MED, V35, P339, DOI 10.2165/00007256-200535040-00004
   Kraemer WJ, 1998, EUR J APPL PHYSIOL O, V78, P69, DOI 10.1007/s004210050389
   KRAEMER WJ, 1995, J APPL PHYSIOL, V78, P976, DOI 10.1152/jappl.1995.78.3.976
   KRAEMER WJ, 1988, MED SCI SPORT EXER, V20, pS152, DOI 10.1249/00005768-198810001-00011
   Lipp M E. N., 2000, Manual do inventario de sintomas do stress para adultos de Lipp (ISSL)
   LUGER A, 1987, NEW ENGL J MED, V316, P1309, DOI 10.1056/NEJM198705213162105
   Marx JO, 2001, MED SCI SPORT EXER, V33, P635, DOI 10.1097/00005768-200104000-00019
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   Moran S, 2007, EUR REV AGING PHYS A, V4, P77, DOI 10.1007/s11556-007-0022-1
   Jeckel CMM, 2010, NEUROIMMUNOMODULAT, V17, P9, DOI 10.1159/000243080
   Paschoal Tatiane, 2004, Estud. psicol. (Natal), V9, P45
   Pauli R, 2006, REV PORT CIENC DESPO, V6, P217
   Pedersen WA, 2001, MECH AGEING DEV, V122, P963, DOI 10.1016/S0047-6374(01)00250-0
   Peinado A.I., 1998, Anales de Psicologia, V14, P83
   Pereira A., 2004, Revista Ciencias Cognicao, V1, P34
   Selye H., 1975, STRESS LIFE
   Starkweather AR, 2007, BIOL RES NURS, V8, P186, DOI 10.1177/1099800406295990
   Steptoe A, 2003, PSYCHOSOM MED, V65, P461, DOI 10.1097/01.PSY.0000035717.78650.A1
   Traustadottir T, 2004, J CLIN ENDOCR METAB, V89, P3248, DOI 10.1210/jc.2003-031713
   Uchida Marco Carlos, 2004, Rev Bras Med Esporte, V10, P165
   URHAUSEN A, 1995, SPORTS MED, V20, P251, DOI 10.2165/00007256-199520040-00004
   van Peer JM, 2008, INT J PSYCHOPHYSIOL, V67, P144, DOI 10.1016/j.ijpsycho.2007.11.001
   VANCAUTER E, 1979, AM J PHYSIOL, V237, pE225, DOI 10.1152/ajpendo.1979.237.3.E255
   VanCauter E, 1996, J CLIN ENDOCR METAB, V81, P2468, DOI 10.1210/jc.81.7.2468
NR 53
TC 28
Z9 31
U1 1
U2 33
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1813-7253
EI 1861-6909
J9 EUR REV AGING PHYS A
JI Eur. Rev. Aging Phys. Act.
PD APR
PY 2014
VL 11
IS 1
BP 25
EP 34
DI 10.1007/s11556-013-0126-8
PG 10
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA AF4KK
UT WOS:000334680600003
OA hybrid
DA 2025-06-11
ER

PT J
AU Liu, CN
   Zhao, MD
   Zhao, YH
   Hu, YJ
AF Liu, Chenning
   Zhao, Meiduo
   Zhao, Yonghua
   Hu, Yuanjia
TI Association between serum total testosterone levels and metabolic
   syndrome among adult women in the United States, NHANES 2011-2016
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE serum total testosterone levels; metabolic syndrome; women; adults;
   NHANES (National Health and Nutrition Examination Survey)
ID POLYCYSTIC-OVARY-SYNDROME; HORMONE-BINDING GLOBULIN; INSULIN-RESISTANCE;
   RISK; COMPONENTS; OBESITY; TRENDS; MEN; AGE
AB ObjectiveTo investigate the association between serum total testosterone (TT) levels and metabolic syndrome (MetS) or its components among adult women. Methods2,678 women from NHANES 2011-2016 were included in this cross-sectional study. MetS was determined according to the National Cholesterol Education Program Adult Treatment Panel III guidelines. The association between serum TT levels and MetS was evaluated by two logistics regression models and the adjusted restricted cubic spline (RCS). Stratified analysis and sensitive analysis were also conducted. ResultsContinuous TT levels were negatively associated with the occurrence of MetS, and the ORs associated with per SD increase in ln TT were 0.70 (95%CI: 0.58-0.85) in 2011-2014 and 0.56 (95%CI: 0.39-0.79) in 2015-2016 in Model A. High TT group were less likely to have MetS (OR=0.60, 95%CI: 0.45-0.80 in 2011-2014 and OR=0.50, 95%CI: 0.32-0.78 in 2015-2016) when compared to the low TT group. When TT levels were divided into quartiles, TT levels were negatively correlated with the incidence of MetS (p for trend < 0.001). Similar trend was observed in Model B. Multivariate-adjusted logistic regression with RCS exhibited that TT had a L-shaped dose-response association with MetS or its components. Interaction analyses revealed that women who were less than 50 years old (OR=0.37, 95%CI: 0.22, 0.63), with depression (OR=0.50, 95%CI: 0.29, 0.87) or being smokers (OR=0.37, 95%CI: 0.23, 0.54) showed lower ORs than those who were over 50 years old (OR=0.66, 95%CI: 0.40, 1.09), without depression (OR=0.59, 95%CI: 0.41, 0.85) or non-smokers (OR=0.59, 95%CI: 0.39, 0.89) when measure the association between ln TT and the occurrence of MetS. ConclusionsOur study indicated that TT levels are negatively correlated with the occurrence of MetS, with interaction effects of age, smoke behaviors, and depressive status.
C1 [Liu, Chenning; Zhao, Yonghua; Hu, Yuanjia] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Macao, Peoples R China.
   [Liu, Chenning; Hu, Yuanjia] Univ Macau, Fac Hlth Sci, Dept Publ Hlth & Med Adm, Macau, Macao, Peoples R China.
   [Zhao, Meiduo] Chinese Acad Med Sci, Peking Union Med Coll, Inst Basic Med Sci, Dept Epidemiol & Biostat,Sch Basic Med, Beijing, Peoples R China.
C3 University of Macau; University of Macau; Chinese Academy of Medical
   Sciences - Peking Union Medical College; Peking Union Medical College
RP Hu, YJ (corresponding author), Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Macao, Peoples R China.; Hu, YJ (corresponding author), Univ Macau, Fac Hlth Sci, Dept Publ Hlth & Med Adm, Macau, Macao, Peoples R China.
EM yuanjiahu@um.edu.mo
RI Zhao, Yonghua/AAC-4728-2019; Hu, Yuanjia/AAW-7721-2021
CR Akishita M, 2010, HYPERTENS RES, V33, P587, DOI 10.1038/hr.2010.43
   Anagnostis P, 2018, METABOLISM, V86, P33, DOI 10.1016/j.metabol.2017.09.016
   Azziz R, 2016, NAT REV DIS PRIMERS, V2, DOI 10.1038/nrdp.2016.57
   Brand JS, 2011, INT J EPIDEMIOL, V40, P189, DOI 10.1093/ije/dyq158
   Centers for Disease Control and Prevention, 2020, NCHS NAT HLTH NUTR E
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Conway G, 2014, EUR J ENDOCRINOL, V171, pP1, DOI 10.1530/EJE-14-0253
   Davis SR, 2022, NAT REV ENDOCRINOL, V18, P490, DOI 10.1038/s41574-022-00685-4
   de Wit AE, 2019, INT J GERIATR PSYCH, V34, P463, DOI 10.1002/gps.5040
   Dumesic DA, 2015, ENDOCR REV, V36, P487, DOI 10.1210/er.2015-1018
   Fatani SH, 2018, DIABET METAB SYND OB, V11, P175, DOI 10.2147/DMSO.S156021
   Feldman HA, 2002, J CLIN ENDOCR METAB, V87, P589, DOI 10.1210/jc.87.2.589
   Golden SH, 2004, AM J EPIDEMIOL, V160, P540, DOI 10.1093/aje/kwh250
   Grundy SM, 2007, J CLIN ENDOCR METAB, V92, P399, DOI 10.1210/jc.2006-0513
   He YQ, 2019, AM J OBSTET GYNECOL, V221, DOI 10.1016/j.ajog.2019.03.011
   Healy LA, 2010, CLIN ONCOL-UK, V22, P281, DOI 10.1016/j.clon.2010.02.001
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   InterLACE Study Team, 2019, HUM REPROD, V34, P881, DOI 10.1093/humrep/dez015
   Kawwass JF, 2017, HUM REPROD, V32, P1450, DOI 10.1093/humrep/dex086
   Kim C, 2014, CURR CARDIOL REP, V16, DOI 10.1007/s11886-014-0467-6
   Kim M, 2020, WORLD J MENS HEALTH, V38, P85, DOI 10.5534/wjmh.190030
   Kische H, 2016, METABOLISM, V65, P1286, DOI 10.1016/j.metabol.2016.05.011
   Krentowska A, 2022, DIABETES-METAB RES, V38, DOI 10.1002/dmrr.3464
   Laaksonen DE, 2004, DIABETES CARE, V27, P1036, DOI 10.2337/diacare.27.5.1036
   Lai YJ, 2023, DIABETES METAB, V49, DOI 10.1016/j.diabet.2022.101415
   Liang JX, 2021, DIABETOL METAB SYNDR, V13, DOI 10.1186/s13098-021-00643-6
   Matsumoto AM, 2002, J GERONTOL A-BIOL, V57, pM76, DOI 10.1093/gerona/57.2.M76
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   Moore KJ, 2020, CIRC RES, V126, P1475, DOI 10.1161/CIRCRESAHA.120.317240
   Mouser JG, 2016, STEROIDS, V115, P62, DOI 10.1016/j.steroids.2016.08.009
   Mulhall JP, 2018, J UROLOGY, V200, P423, DOI 10.1016/j.juro.2018.03.115
   Patel SM, 2009, J CLIN ENDOCR METAB, V94, P4776, DOI 10.1210/jc.2009-0740
   Polotsky AJ, 2012, J CLIN ENDOCR METAB, V97, pE868, DOI 10.1210/jc.2011-3357
   Rao PM, 2013, NAT REV ENDOCRINOL, V9, P479, DOI 10.1038/nrendo.2013.122
   Rodriguez A, 2007, J CLIN ENDOCR METAB, V92, P3568, DOI 10.1210/jc.2006-2764
   Saad F, 2009, J STEROID BIOCHEM, V114, P40, DOI 10.1016/j.jsbmb.2008.12.022
   Skiba MA, 2019, J CLIN ENDOCR METAB, V104, P5379, DOI 10.1210/jc.2019-01357
   Stepto NK, 2013, HUM REPROD, V28, P777, DOI 10.1093/humrep/des463
   Torkler S, 2011, AGING MALE, V14, P176, DOI 10.3109/13685538.2010.529194
   Winters SJ, 2000, FERTIL STERIL, V73, P724, DOI 10.1016/S0015-0282(99)00641-X
NR 40
TC 14
Z9 14
U1 2
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD FEB 9
PY 2023
VL 14
AR 1053665
DI 10.3389/fendo.2023.1053665
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 9D2XA
UT WOS:000935964300001
PM 36843599
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Heinzer, R
   Vat, S
   Marques-Vidal, P
   Marti-Soler, H
   Andries, D
   Tobback, N
   Mooser, V
   Preisig, M
   Malhotra, A
   Waeber, G
   Vollenweider, P
   Tafti, M
   Haba-Rubio, J
AF Heinzer, R.
   Vat, S.
   Marques-Vidal, P.
   Marti-Soler, H.
   Andries, D.
   Tobback, N.
   Mooser, V.
   Preisig, M.
   Malhotra, A.
   Waeber, G.
   Vollenweider, P.
   Tafti, M.
   Haba-Rubio, J.
TI Prevalence of sleep-disordered breathing in the general population: the
   HypnoLaus study
SO LANCET RESPIRATORY MEDICINE
LA English
DT Article
ID CARDIOVASCULAR RISK-FACTORS; POSITIVE AIRWAY PRESSURE; APNEA-HYPOPNEA;
   HEART HEALTH; METABOLIC SYNDROME; ASSOCIATION; ADULTS; MEN;
   HYPERTENSION; COMMUNITY
AB Background Sleep-disordered breathing is associated with major morbidity and mortality. However, its prevalence has mainly been selectively studied in populations at risk for sleep-disordered breathing or cardiovascular diseases. Taking into account improvements in recording techniques and new criteria used to define respiratory events, we aimed to assess the prevalence of sleep-disordered breathing and associated clinical features in a large population-based sample.
   Methods Between Sept 1, 2009, and June 30, 2013, we did a population-based study (HypnoLaus) in Lausanne, Switzerland. We invited a cohort of 3043 consecutive participants of the CoLaus/PsyCoLaus study to take part. Polysomnography data from 2121 people were included in the final analysis. 1024 (48%) participants were men, with a median age of 57 years (IQR 49-68, range 40-85) and mean body-mass index (BMI) of 25.6 kg/m(2) (SD 4.1). Participants underwent complete polysomnographic recordings at home and had extensive phenotyping for diabetes, hypertension, metabolic syndrome, and depression. The primary outcome was prevalence of sleep-disordered breathing, assessed by the apnoea-hypopnoea index.
   Findings The median apnoea-hypopnoea index was 6-9 events per h (IQR 2.7-14.1) in women and 14.9 per h (7.2-27.1) in men. The prevalence of moderate-to-severe sleep-disordered breathing (>= 15 events per h) was 23.4% (95% CI 20.9-26.0) in women and 49.7% (46.6-52.8) in men. After multivariable adjustment, the upper quartile for the apnoea-hypopnoea index (>20.6 events per h) was associated independently with the presence of hypertension (odds ratio 1.60, 95% CI 1.14-2.26; p=0.0292 for trend across severity quartiles), diabetes (2.00, 1.05-3.99; p=0.0467), metabolic syndrome (2.80, 1.86-4.29; p<0.0001), and depression (1.92, 1.01-3.64; p=0.0292).
   Interpretation The high prevalence of sleep-disordered breathing recorded in our population-based sample might be attributable to the increased sensitivity of current recording techniques and scoring criteria. These results suggest that sleep-disordered breathing is highly prevalent, with important public health outcomes, and that the definition of the disorder should be revised.
C1 [Heinzer, R.; Vat, S.; Andries, D.; Tobback, N.; Tafti, M.; Haba-Rubio, J.] Univ Lausanne Hosp, Ctr Invest & Res Sleep, Lausanne, Switzerland.
   [Heinzer, R.] Univ Lausanne Hosp, Dept Pulm, Lausanne, Switzerland.
   [Marques-Vidal, P.; Waeber, G.; Vollenweider, P.] Univ Lausanne Hosp, Dept Internal Med, Lausanne, Switzerland.
   [Mooser, V.] Univ Lausanne Hosp, Dept Lab, Lausanne, Switzerland.
   [Preisig, M.] Univ Lausanne Hosp, Dept Psychiat, Lausanne, Switzerland.
   [Vat, S.] Univ Hosp Montreal, Dept Pulm Med, Montreal, PQ, Canada.
   [Marti-Soler, H.] Univ Lausanne, Inst Social & Prevent Med, CH-1011 Lausanne, Switzerland.
   [Tafti, M.] Univ Lausanne, Ctr Integrat Genom, CH-1011 Lausanne, Switzerland.
   [Malhotra, A.] Univ So Calif, Div Pulm & Crit Care, La Jolla, CA USA.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; University of Lausanne; University of Southern
   California
RP Heinzer, R (corresponding author), Univ Lausanne, Univ Lausanne Hosp, Ctr Invest & Res Sleep, CH-1011 Lausanne, Switzerland.
EM raphael.heinzer@chuv.ch
RI Marti-Soler, Helena/AAA-7659-2019; Preisig, Martin/H-3441-2016;
   Vollenweider, Peter/Q-4603-2016; Tafti, Mehdi/A-8887-2017;
   Marques-Vidal, Pedro/C-9449-2009
OI Heinzer, Raphael/0000-0002-3215-7788; Vollenweider,
   Peter/0000-0002-0765-896X; Tafti, Mehdi/0000-0002-6997-3914;
   Marti-Soler, Helena/0000-0002-7127-205X; Waeber,
   Gerard/0000-0003-4193-788X; haba-rubio, jose/0000-0001-7466-6436;
   Preisig, Martin/0000-0001-5689-4259; Marques-Vidal,
   Pedro/0000-0002-4548-8500
FU Faculty of Biology and Medicine of Lausanne, Lausanne University
   Hospital; Swiss National Science Foundation; Leenaards Foundation;
   GlaxoSmithKline; Ligue Pulmonaire Vaudoise
FX Faculty of Biology and Medicine of Lausanne, Lausanne University
   Hospital, Swiss National Science Foundation, Leenaards Foundation,
   GlaxoSmithKline, Ligue Pulmonaire Vaudoise.
CR Aurora RN, 2013, LANCET RESP MED, V1, P329, DOI 10.1016/S2213-2600(13)70039-0
   Ballester E, 1998, EUR RESPIR J, V11, P880, DOI 10.1183/09031936.98.11040880
   Barbé F, 2012, JAMA-J AM MED ASSOC, V307, P2161, DOI 10.1001/jama.2012.4366
   BEARPARK H, 1995, AM J RESP CRIT CARE, V151, P1459, DOI 10.1164/ajrccm.151.5.7735600
   Berry RB, 2012, J CLIN SLEEP MED, V8, P597, DOI 10.5664/jcsm.2172
   Bixler EO, 2001, AM J RESP CRIT CARE, V163, P608, DOI 10.1164/ajrccm.163.3.9911064
   Coughlin SR, 2004, EUR HEART J, V25, P735, DOI 10.1016/j.ehj.2004.02.021
   Durán J, 2001, AM J RESP CRIT CARE, V163, P685, DOI 10.1164/ajrccm.163.3.2005065
   Firmann M, 2008, BMC CARDIOVASC DISOR, V8, DOI 10.1186/1471-2261-8-6
   Flemons WW, 1999, SLEEP, V22, P667, DOI 10.1093/sleep/22.5.667
   Gottlieb DJ, 2014, NEW ENGL J MED, V370, P2276, DOI 10.1056/NEJMoa1306766
   Gottlieb DJ, 2010, CIRCULATION, V122, P352, DOI 10.1161/CIRCULATIONAHA.109.901801
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Iber C, 2017, AASM MANUAL SCORING
   Ip MSM, 2001, CHEST, V119, P62, DOI 10.1378/chest.119.1.62
   Kendzerska T, 2014, AM J RESP CRIT CARE, V190, P218, DOI 10.1164/rccm.201312-2209OC
   Marin JM, 2005, LANCET, V365, P1046, DOI 10.1016/S0140-6736(05)71141-7
   Marques-Vidal P, 2012, ASSESSING ASS MENTAL
   Peker Y, 2002, AM J RESP CRIT CARE, V166, P159, DOI 10.1164/rccm.2105124
   Peppard PE, 2006, ARCH INTERN MED, V166, P1709, DOI 10.1001/archinte.166.16.1709
   Peppard PE, 2013, AM J EPIDEMIOL, V177, P1006, DOI 10.1093/aje/kws342
   Peppard PE, 2000, NEW ENGL J MED, V342, P1378, DOI 10.1056/NEJM200005113421901
   Preisig M, 2009, BMC PSYCHIATRY, V9, DOI 10.1186/1471-244X-9-9
   Quan SF, 1997, SLEEP, V20, P1077
   Redline S, 1998, SLEEP, V21, P759
   Redline S, 2014, AM J RESP CRIT CARE, V189, P335, DOI 10.1164/rccm.201309-1735OC
   Redline S, 2010, AM J RESP CRIT CARE, V182, P269, DOI 10.1164/rccm.200911-1746OC
   Reichmuth KJ, 2005, AM J RESP CRIT CARE, V172, P1590, DOI 10.1164/rccm.200504-637OC
   Thurnheer R, 2001, AM J RESP CRIT CARE, V164, P1914, DOI 10.1164/ajrccm.164.10.2102104
   Tishler PV, 2003, JAMA-J AM MED ASSOC, V289, P2230, DOI 10.1001/jama.289.17.2230
   Tufik S, 2010, SLEEP MED, V11, P441, DOI 10.1016/j.sleep.2009.10.005
   WHITE DP, 1995, THORAX, V50, P797, DOI 10.1136/thx.50.7.797
   Yaggi HK, 2005, NEW ENGL J MED, V353, P2034, DOI 10.1056/NEJMoa043104
   YOUNG T, 1993, NEW ENGL J MED, V328, P1230, DOI 10.1056/NEJM199304293281704
NR 34
TC 1731
Z9 1808
U1 5
U2 150
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2213-2600
J9 LANCET RESP MED
JI Lancet Resp. Med.
PD APR
PY 2015
VL 3
IS 4
BP 310
EP 318
DI 10.1016/S2213-2600(15)00043-0
PG 9
WC Critical Care Medicine; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Respiratory System
GA CG2BD
UT WOS:000353079000022
PM 25682233
OA Green Submitted, Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Chong, KS
   Chang, YH
   Yang, CT
   Chou, CK
   Ou, H
   Kuo, SH
AF Chong, Kah Suan
   Chang, Yi-Hsin
   Yang, Chun-Ting
   Chou, Chu-Kuang
   Ou, Huang-Tz
   Kuo, Shihchen
TI Longitudinal economic burden of incident complications among metabolic
   syndrome populations
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Metabolic syndrome; Cardiovascular disease; Complications; Microvascular
   disease; Cancer; Cost
ID HEALTH-CARE COSTS; CARDIOVASCULAR-DISEASE; OBESITY; RISK; PREVALENCE;
   TAIWAN
AB BackgroundThis study quantifies the longitudinal economic burden for a wide spectrum of incident complications, metabolic syndrome (MS)-related risk factors, and comorbidities in patients with MS.MethodsThis retrospective study utilized linked data from the 2013 National Health Interview Survey and the 2012-2021 National Health Insurance Research Database to identify MS individuals and their characteristics. The incidence rate of each complication was calculated as the number of complication events in the study period divided by the total person-years during follow-up. The healthcare costs of complications were analyzed using a generalized estimating equation model to determine the cost impact of complications after adjustment for patients' characteristics. Sensitivity analyses on variables with high missing rates (i.e., cause of death, body mass index) were performed.ResultsAmong 837 identified MS individuals over 8.28 (+/- 1.35) years of follow-up, the most frequent complications were microvascular diseases (incidence rate for nephropathy/retinopathy/neuropathy: 6.49/2.64/2.08 events per 100 person-years), followed by cardiovascular diseases (2.47), peripheral vascular diseases (2.01), and cancers (1.53). Death was the costliest event (event-year cost per person: USD 16,429) and cancers were the most expensive complications (USD 9,127-11,083 for non-MS- and MS-related cancers). Developing non-MS/MS-related cancers, cardiovascular diseases, and obesity-related medical conditions increased annual costs by 273% (95% CI: 181-397%)/175% (105-269%), 159% (118-207%), and 140% (84-214%), respectively. Microvascular diseases had the lowest cost impact on annual costs (i.e., 27% [17-39%]/27% [11-46%]/24% [11-37%] increases for nephropathy/neuropathy/retinopathy, respectively). Having existing comorbidities increased annual costs by 20% (osteoarthritis) to 108% (depression). Having morbid obesity (i.e., body mass index >= 35 kg/m2) increased annual costs by 58% (30-91%).ConclusionsThe economic burden from costly incident complications (i.e., cardiovascular diseases, peripheral vascular diseases, cancers), MS-related risk factors (i.e., morbid obesity), and comorbidities (i.e., depression) highlight the urgent need for early intervention to prevent MS and its progression. The comprehensive cost estimates reported in this study can facilitate the parameterization of economic analyses to identify cost-effective interventions for these patients.
C1 [Chong, Kah Suan; Chang, Yi-Hsin; Yang, Chun-Ting; Ou, Huang-Tz; Kuo, Shihchen] Natl Cheng Kung Univ, Inst Clin Pharm & Pharmaceut Sci, Coll Med, Tainan, Taiwan.
   [Chang, Yi-Hsin; Ou, Huang-Tz] Natl Cheng Kung Univ, Coll Med, Dept Pharm, Tainan, Taiwan.
   [Yang, Chun-Ting] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Pharmacoepidemiol & Pharmacoecon, Boston, MA USA.
   [Chou, Chu-Kuang] Chia Yi Christian Hosp, Ditmanson Med Fdn Chia, Dept Internal Med, Div Gastroenterol & Hepatol, Chiayi, Taiwan.
   [Chou, Chu-Kuang] Chia Yi Christian Hosp, Ditmanson Med Fdn, Obes Ctr, Chiayi, Taiwan.
   [Kuo, Shihchen] Univ Michigan, Med Sch, Dept Internal Med, Div Metab Endocrinol & Diabet, Ann Arbor, MI USA.
C3 National Cheng Kung University; National Cheng Kung University; Harvard
   University; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Harvard Medical School; University of Michigan System;
   University of Michigan
RP Ou, H (corresponding author), Natl Cheng Kung Univ, Coll Med, Dept Pharm, Tainan, Taiwan.
EM huangtz@mail.ncku.edu.tw
RI hu, cheng/AAY-5956-2021; Chou, Chu-kuang/AAF-5875-2020
OI Yang, Chun-Ting/0000-0002-5747-6806
FU Ministry of Science and Technology, Taiwan
FX The authors are grateful to the Data Science Center, National Cheng Kung
   University Hospital, for providing administrative and technical support.
   We'd like to thank Adam Przywecki for proofreading the manuscript.
CR Al-Omar HA, 2023, ADV THER, V40, P1430, DOI 10.1007/s12325-023-02426-z
   Boudreau DM, 2009, METAB SYNDR RELAT D, V7, P305, DOI 10.1089/met.2008.0070
   Caleyachetty R, 2021, LANCET DIABETES ENDO, V9, P419, DOI 10.1016/S2213-8587(21)00088-7
   Caro JJ, 2007, VALUE HEALTH, V10, pS12, DOI 10.1111/j.1524-4733.2006.00150.x
   Chen HY, 2020, DIABETES CARE, V43, P1732, DOI 10.2337/dc20-0072
   de Francesco M, 2018, VALUE HEALTH, V21, pS454, DOI 10.1016/j.jval.2018.09.2679
   Deng L, 2024, SAUDI MED J, V45, P446, DOI 10.1002/cncr.35235
   Esposito K, 2012, DIABETES CARE, V35, P2402, DOI 10.2337/dc12-0336
   He SY, 2022, DIABETES RES CLIN PR, V191, DOI 10.1016/j.diabres.2022.110048
   Health Promotion Administration Ministry of Health and Welfare (Taiwan), National Health Interview Survey (NHIS)
   Health Promotion Administration Ministry of Health and Welfare Taiwan, Introduction of Aging and Chronic Disease Control Division
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Hsieh CY, 2019, CLIN EPIDEMIOL, V11, P349, DOI 10.2147/CLEP.S196293
   Huang KC, 2008, OBES REV, V9, P32, DOI 10.1111/j.1467-789X.2007.00435.x
   Kao LT, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0137459
   Kim D, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-88233-4
   Kim Dongwoo, 2015, J Prev Med Public Health, V48, P180, DOI 10.3961/jpmph.15.022
   Kremers HM, 2014, J BONE JOINT SURG AM, V96A, P718, DOI 10.2106/JBJS.M.00819
   Li Q, 2015, J MED ECON, V18, P1020, DOI 10.3111/13696998.2015.1067623
   Mozaffary A, 2014, EUR J CLIN NUTR, V68, P853, DOI 10.1038/ejcn.2014.91
   Nerkar D., 2015, Int J Pharm Pharm Sci, V7, P22
   Nichols GA, 2011, METAB SYNDR RELAT D, V9, P127, DOI 10.1089/met.2010.0105
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Park D, 2023, JACC-ASIA, V3, P491, DOI 10.1016/j.jacasi.2023.02.007
   Rudisill C, 2016, CLIN OBES, V6, P225, DOI 10.1111/cob.12144
   Scholze J, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-529
   Schultz AB, 2009, METAB SYNDR RELAT D, V7, P459, DOI 10.1089/met.2009.0008
   Shichman I, 2023, J ARTHROPLASTY, V38, P1037, DOI 10.1016/j.arth.2022.12.039
   Tápias FS, 2021, BMC HEALTH SERV RES, V21, DOI 10.1186/s12913-021-06428-x
   Tenenbaum A, 2004, INT J CARDIOL, V97, P167, DOI 10.1016/j.ijcard.2003.07.033
   Tenenbaum A, 2003, CARDIOVASC DIABETOL, V2, DOI 10.1186/1475-2840-2-4
   Vesikansa Aino, 2023, J Mark Access Health Policy, V11, P2166313, DOI 10.1080/20016689.2023.2166313
   who, Obesity
   Yeh CJ, 2011, ASIA PAC J CLIN NUTR, V20, P292
   Yeh TL, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0246378
   Yoo JS, 2020, KOREAN J INTERN MED, V35, P936, DOI 10.3904/kjim.2016.343
   Yu TY, 2021, J DIABETES INVEST, V12, P2108, DOI 10.1111/jdi.13691
NR 37
TC 6
Z9 6
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD JUL 10
PY 2024
VL 23
IS 1
AR 246
DI 10.1186/s12933-024-02335-7
PG 10
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA YQ7G8
UT WOS:001270008600002
PM 38987782
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Moyo-Chilufya, M
   Maluleke, K
   Kgarosi, K
   Muyoyeta, M
   Hongoro, C
   Musekiwa, A
AF Moyo-Chilufya, Maureen
   Maluleke, Kuhlula
   Kgarosi, Kabelo
   Muyoyeta, Monde
   Hongoro, Charles
   Musekiwa, Alfred
TI The burden of non-communicable diseases among people living with HIV in
   Sub-Saharan Africa: a systematic review and meta-analysis
SO ECLINICALMEDICINE
LA English
DT Review
DE Non-communicable diseases; People living with HIV; Sub-Saharan Africa;
   HIV/AIDS; Systematic review; Meta-analysis
ID HUMAN-IMMUNODEFICIENCY-VIRUS; INITIATING ANTIRETROVIRAL THERAPY; MAJOR
   DEPRESSIVE DISORDER; PUBLIC-HEALTH FACILITIES; TYPE-2 DIABETES-MELLITUS;
   ART-NAIVE PATIENTS; RISK-FACTORS; METABOLIC SYNDROME; INFECTED PATIENTS;
   POSITIVE INDIVIDUALS
AB Background Non-communicable diseases (NCDs) are increasing among people living with HIV (PLHIV), especially in Sub-Saharan Africa (SSA). We determined the prevalence of NCDs and NCD risk factors among PLHIV in SSA to inform health policy makers.Methods We conducted a systematic review and meta-analysis on the prevalence of NCDs and risk factors among PLHIV in SSA. We comprehensively searched PubMed/MEDLINE, Scopus, and EBSCOhost (CINAHL) electronic databases for sources published from 2010 to July 2023. We applied the random effects meta-analysis model to pool the results using STATA. The systematic review protocol was registered on PROSPERO (registration number: CRD42021258769).Findings We included 188 studies from 21 countries in this meta-analysis. Our findings indicate pooled prevalence estimates for hypertension (20.1% [95% CI:17.5-22.7]), depression (30.4% [25.3-35.4]), diabetes (5.4% [4.4-6.4]), cervical cancer (1.5% [0.1-2.9]), chronic respiratory diseases (7.1% [4.0-10.3]), overweight/obesity (32.2% [29.7-34.7]), hypercholesterolemia (21.3% [16.6-26.0]), metabolic syndrome (23.9% [19.5-28.7]), alcohol consumption (21.3% [17.9-24.6]), and smoking (6.4% [5.2-7.7]).Interpretation People living with HIV have a high prevalence of NCDs and their risk factors including hypertension, depression, overweight/obesity, hypercholesterolemia, metabolic syndrome and alcohol consumption. We recom-mend strengthening of health systems to allow for improved integration of NCDs and HIV services in public health facilities in SSA. NCD risk factors such as obesity, hypercholesterolemia, and alcohol consumption can be addressed through health promotion campaigns. There is a need for further research on the burden of NCDs among PLHIV in most of SSA. Copyright (c) 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Moyo-Chilufya, Maureen; Maluleke, Kuhlula; Kgarosi, Kabelo; Hongoro, Charles; Musekiwa, Alfred] Univ Pretoria, Fac Hlth Sci, Sch Hlth Syst & Publ Hlth, Pretoria, South Africa.
   [Muyoyeta, Monde] Ctr Infect Dis Res Zambia, Lusaka, Zambia.
   [Hongoro, Charles] Human Sci Res Council, Pretoria, South Africa.
   [Musekiwa, Alfred] Fac Hlth Sci, 31 Room 5-10,Level 5,HW Snyman Bldg North,Bophel, ZA-0084 Pretoria, South Africa.
C3 University of Pretoria; Human Sciences Research Council-South Africa
RP Musekiwa, A (corresponding author), Fac Hlth Sci, 31 Room 5-10,Level 5,HW Snyman Bldg North,Bophel, ZA-0084 Pretoria, South Africa.
EM Alfred.Musekiwa@up.ac.za
RI Chilufya, Maureen/LRB-6846-2024; Musekiwa, Alfred/IUP-3659-2023
OI Kgarosi, Kabelo/0000-0003-4236-3339; Musekiwa,
   Alfred/0000-0001-5880-3680; Hongoro, Charles/0000-0002-9715-4940; Moyo -
   Chilufya, Maureen/0000-0003-2312-0972
CR Abiodun O, 2022, AIDS CARE, V34, P741, DOI 10.1080/09540121.2021.1944595
   Achila OO, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0270838
   Achwoka D, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0235606
   Achwoka D, 2019, BMC PUBLIC HEALTH, V19, DOI 10.1186/s12889-019-6716-2
   Adebajo SB, 2023, JAIDS-J ACQ IMM DEF, V92, P50, DOI 10.1097/QAI.0000000000003096
   Adedokun TA, 2023, FRONT REPROD HEALTH, V5, DOI 10.3389/frph.2023.1092211
   Ahmed HA, 2022, BMJ OPEN, V12, DOI 10.1136/bmjopen-2022-062352
   Akena D, 2013, AIDS BEHAV, V17, P2802, DOI 10.1007/s10461-012-0383-y
   Albrecht S, 2019, AIDS, V33, P1031, DOI 10.1097/QAD.0000000000002171
   Amberbir A, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0210629
   Amutuhaire W, 2023, OPEN FORUM INFECT DI, V10, DOI 10.1093/ofid/ofad241
   Appiah LT, 2019, CLIN CARDIOL, DOI 10.1002/clc.23273
   Ataro Z, 2018, HIV AIDS-RES PALLIAT, V10, P181, DOI 10.2147/HIV.S176877
   Ayisi-Boateng NK, 2022, AIDS CARE, V34, P1547, DOI 10.1080/09540121.2022.2029821
   Badru O, 2022, J ASSOC NURSE AIDS C, V33, pE6, DOI 10.1097/JNC.0000000000000309
   Bauer S, 2017, GLOBAL HEALTH ACTION, V10, DOI 10.1080/16549716.2017.1359923
   Beyene Gebrezgiabher Berhe, 2019, Depress Res Treat, V2019, P3250431, DOI 10.1155/2019/3250431
   Bigna JJ, 2020, J HYPERTENS, V38, P1659, DOI 10.1097/HJH.0000000000002446
   Bigna JJ, 2018, LANCET GLOB HEALTH, V6, pE182, DOI 10.1016/S2214-109X(17)30451-5
   Bitew H., 2016, Depression Res Treat, P1, DOI DOI 10.1155/2016/8913160
   Bosho DD, 2018, DIABETOL METAB SYNDR, V10, DOI 10.1186/s13098-018-0312-y
   Brennan AT, 2023, ECLINICALMEDICINE, V57, DOI 10.1016/j.eclinm.2023.101836
   Brennan AT, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204020
   Buzaalirwa L, 2022, BMC HEALTH SERV RES, V22, DOI 10.1186/s12913-022-08362-y
   Byonanebye DM, 2023, PLOS ONE, V18, DOI 10.1371/journal.pone.0282001
   Chang D, 2022, J INT AIDS SOC, V25, DOI 10.1002/jia2.25985
   Cheza A, 2022, AFR HEALTH SCI, V22, P443, DOI 10.4314/ahs.v22i4.50
   Chibanda D, 2016, BMC PSYCHIATRY, V16, DOI 10.1186/s12888-016-0764-2
   Chihota BV, 2022, J INT AIDS SOC, V25, DOI 10.1002/jia2.26047
   Chimbetete C, 2017, TROP MED INT HEALTH, V22, P839, DOI 10.1111/tmi.12896
   Chipanta D, 2022, AIDS CARE, V34, P957, DOI 10.1080/09540121.2021.1966693
   Chiwandire N, 2021, BMC PUBLIC HEALTH, V21, DOI 10.1186/s12889-021-10502-8
   Codjo H L, 2022, J Med Vasc, V47, P71, DOI 10.1016/j.jdmv.2022.04.008
   Dakum P, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000025399
   Dave JA, 2011, JAIDS-J ACQ IMM DEF, V57, P284, DOI 10.1097/QAI.0b013e318221863f
   de Vries AEM, 2023, TROP MED INT HEALTH, V28, P367, DOI 10.1111/tmi.13871
   Dhokotera T, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2020-043941
   Diallo Ismael, 2017, J Int Assoc Provid AIDS Care, V16, P405, DOI 10.1177/2325957417709088
   Dimala CA, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0148100
   Divala OH, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-3916-x
   Dorsisa Beyene, 2020, Psychiatry J, V2020, P5414072, DOI 10.1155/2020/5414072
   Duko B, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00290
   Duko B, 2018, ANN GEN PSYCHIATR, V17, DOI 10.1186/s12991-018-0215-1
   Dzudie A, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0253742
   Dzudzor B, 2023, AIDS RES TREAT, V2023, DOI 10.1155/2023/1566001
   Egbe CO, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4467-5
   Ekrikpo UE, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2017-019664
   Ekun OA, 2021, PAN AFR MED J, V38, DOI 10.11604/pamj.2021.38.206.26791
   Enriquez R, 2022, J INT AIDS SOC, V25, DOI 10.1002/jia2.25901
   Farrant MT, 2022, MEDICINE, V101, DOI 10.1097/MD.0000000000031366
   Faurholt-Jepsen D, 2019, AIDS, V33, P1595, DOI 10.1097/QAD.0000000000002249
   Filiatreau LM, 2022, J AFFECT DISORDERS, V308, P421, DOI 10.1016/j.jad.2022.04.061
   Fink DL, 2022, AIDS, V36, P1987, DOI 10.1097/QAD.0000000000003360
   Fiseha T, 2019, INT J HYPERTENS, V2019, DOI 10.1155/2019/4103604
   Freeman M, 2007, AIDS CARE, V19, P1201, DOI 10.1080/09540120701426482
   Furuya-Kanamori L, 2018, INT J EVID-BASED HEA, V16, P195, DOI 10.1097/XEB.0000000000000141
   Gaynes BN, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041699
   Gebremariam Etsay Hailu, 2017, Psychiatry J, V2017, P2301524, DOI 10.1155/2017/2301524
   Gebrie A, 2020, DIABETOL METAB SYNDR, V12, DOI 10.1186/s13098-020-00527-1
   Getahun Zenebework, 2020, J Comorb, V10, p2235042X19899319, DOI 10.1177/2235042X19899319
   Gilbert RF, 2022, BMC PULM MED, V22, DOI 10.1186/s12890-021-01792-0
   Guira Oumar, 2016, J Int Assoc Provid AIDS Care, V15, P159, DOI 10.1177/2325957415601503
   Haas AD, 2023, AIDS BEHAV, V27, P1849, DOI 10.1007/s10461-022-03916-x
   Hailu W, 2021, INT MED CASE REP J, V14, P503, DOI 10.2147/IMCRJ.S323233
   Hamooya BM, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000025236
   Harimenshi D, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-24997-7
   Harris TG, 2021, AJAR-AFR J AIDS RES, V20, P107, DOI 10.2989/16085906.2021.1887301
   Hertz JT, 2022, GLOB PUBLIC HEALTH, V17, P3747, DOI 10.1080/17441692.2022.2049344
   Hofman K, 2014, SAMJ S AFR MED J, V104, P647, DOI [10.7196/samj.8727, 10.7196/SAMJ.8727]
   Hopkins KL, 2021, ECLINICALMEDICINE, V38, DOI 10.1016/j.eclinm.2021.101015
   Hyle EP, 2019, J INT AIDS SOC, V22, DOI 10.1002/jia2.25274
   Isa SE, 2016, CLIN INFECT DIS, V63, P830, DOI 10.1093/cid/ciw381
   Jackson IL, 2022, PAN AFR MED J, V41, DOI 10.11604/pamj.2022.41.153.21809
   Jaquet A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0090625
   Jeremiah K, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0230723
   Julius H, 2011, CURR HIV RES, V9, P247, DOI 10.2174/157016211796320360
   Juma K, 2019, CARDIOVASC J AFR, V30, P52, DOI 10.5830/CVJA-2018-064
   Kafuruki L, 2013, INFECT AGENTS CANCER, V8, DOI 10.1186/1750-9378-8-45
   Kagaruki GB, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-904
   Kaluba L, 2023, BMC CARDIOVASC DISOR, V23, DOI 10.1186/s12872-023-03093-2
   Kamkuemah M, 2023, PLOS ONE, V18, DOI 10.1371/journal.pone.0266637
   Kanmogne GD, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0171956
   Kansiime S, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0221022
   Kavishe BB, 2022, AM J HYPERTENS, V35, P929, DOI 10.1093/ajh/hpac085
   Kayongo A, 2023, MICROBIOL SPECTR, V11, DOI 10.1128/spectrum.02139-21
   Kayongo A, 2020, COPD, V17, P297, DOI 10.1080/15412555.2020.1769583
   Kemal A, 2021, J OBES, V2021, DOI 10.1155/2021/1578653
   Nguyen KA, 2017, INT J ENDOCRINOL, V2017, DOI 10.1155/2017/1613657
   Kinyanda E, 2017, J AFFECT DISORDERS, V212, P117, DOI 10.1016/j.jad.2017.01.033
   Kiyimba T, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.976744
   Kohler RE, 2016, INT J STD AIDS, V27, P753, DOI 10.1177/0956462415592999
   Kotey M, 2022, PAN AFR MED J, V42, DOI 10.11604/pamj.2022.42.294.35134
   Kubiak RW, 2021, BMC INFECT DIS, V21, DOI 10.1186/s12879-021-06473-1
   Kummerow M, 2019, S AFR J HIV MED, V20, DOI 10.4102/sajhivmed.v20i1.1010
   Kwarisiima D, 2019, BMC PUBLIC HEALTH, V19, DOI 10.1186/s12889-019-6838-6
   L'akoa RM, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-228
   Lubega G, 2021, PAN AFR MED J, V38, DOI 10.11604/pamj.2021.38.216.28034
   Lukas K, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0258576
   Maganga E, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0134410
   Magodoro IM, 2022, INT J INFECT DIS, V121, P217, DOI 10.1016/j.ijid.2022.05.035
   Malava JK, 2018, MALAWI MED J, V30, P236, DOI 10.4314/mmj.v30i4.5
   Malindisa E, 2023, BMC ENDOCR DISORD, V23, DOI 10.1186/s12902-023-01340-3
   Manavalan P, 2020, J CLIN HYPERTENS, V22, P1518, DOI 10.1111/jch.13929
   Manne-Goehler J, 2019, J INT AIDS SOC, V22, DOI 10.1002/jia2.25213
   Manuthu E M, 2008, East Afr Med J, V85, P10
   Marwick KFM, 2010, AIDS CARE, V22, P415, DOI 10.1080/09540120903253981
   Mashinya F, 2015, AIDS RES THER, V12, DOI 10.1186/s12981-015-0083-6
   Masyuko SJ, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000020845
   Mateen FJ, 2013, J HYPERTENS, V31, P1372, DOI 10.1097/HJH.0b013e328360de1c
   Mbuthia Grace Wambura, 2021, Int J Hypertens, V2021, P5544916, DOI 10.1155/2021/5544916
   Memiah P, 2021, J INTERF CYTOK RES, V41, P291, DOI 10.1089/jir.2021.0059
   Memiah P, 2015, AFR J REPROD HEALTH, V19, P133
   Memiah P, 2012, AIDS RES TREAT, V2012, DOI 10.1155/2012/953743
   Menon S, 2018, VIROL J, V15, DOI 10.1186/s12985-018-0961-3
   Migisha R, 2023, CLIN HYPERTENS, V29, DOI 10.1186/s40885-022-00230-5
   Mocumbi AO, 2020, CARDIOVASC DIAGN THE, V10, P526, DOI 10.21037/cdt.2019.12.02
   Mogaka JN, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0262400
   Mohammed AE, 2015, DIABET METAB SYND OB, V8, P197, DOI 10.2147/DMSO.S80084
   Monroe AK, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0262204
   Moucheraud C, 2022, AIDS CARE, V34, P1602, DOI 10.1080/09540121.2021.2014778
   Moyo M, 2022, BMJ OPEN, V12, DOI 10.1136/bmjopen-2021-055895
   Msoka TF, 2018, BMC INFECT DIS, V18, DOI 10.1186/s12879-018-3637-0
   Mugisha JO, 2016, GLOBAL HEALTH ACTION, V9, DOI 10.3402/gha.v9.31098
   Muhammad FY, 2017, DIABETES METAB SYND, V11, pS523, DOI 10.1016/j.dsx.2017.03.046
   Mukeba-Tshialala D, 2017, Bull Soc Pathol Exot, V110, P301, DOI 10.1007/s13149-017-0561-2
   Mulindwa F, 2023, AIDS RES THER, V20, DOI 10.1186/s12981-023-00510-6
   Mulugeta H, 2021, HIV AIDS-RES PALLIAT, V13, P889, DOI 10.2147/HIV.S329838
   Mungo C, 2013, INT J GYNECOL OBSTET, V123, P231, DOI 10.1016/j.ijgo.2013.07.010
   Mutebi RK, 2023, INTEGR BLOOD PRESS C, V16, P11, DOI 10.2147/IBPC.S403023
   Muyanja D, 2016, AIDS PATIENT CARE ST, V30, P4, DOI 10.1089/apc.2015.0213
   Mwakyandile TM, 2023, BMC CARDIOVASC DISOR, V23, DOI 10.1186/s12872-023-03332-6
   Myer L, 2008, AIDS PATIENT CARE ST, V22, P147, DOI 10.1089/apc.2007.0102
   Nakimuli-Mpungu E, 2011, J AFFECT DISORDERS, V135, P160, DOI 10.1016/j.jad.2011.07.009
   Ndizeye Z, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2019-029088
   Ndona MM, 2012, INT J GEN MED, V5, P983, DOI 10.2147/IJGM.S32167
   Ngu Roland Cheofor, 2018, BMC Res Notes, V11, P305, DOI 10.1186/s13104-018-3444-0
   Ngum PA, 2017, NEUROL THER, V6, P103, DOI 10.1007/s40120-017-0065-9
   Niwaha AJ, 2022, J HUM HYPERTENS, V36, P144, DOI 10.1038/s41371-020-00464-6
   Niwaha AJ, 2021, GLOB HEART, V16, DOI 10.5334/gh.858
   Njue JK, 2021, BIOMED RES INT-UK, V2021, DOI 10.1155/2021/2250690
   Njuguna B, 2018, J DIABETES RES, V2018, DOI 10.1155/2018/6916497
   North CM, 2018, LUNG, V196, P49, DOI 10.1007/s00408-017-0080-8
   Noumegni SRN, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0543-1
   Nsagha DS, 2015, BMC CARDIOVASC DISOR, V15, DOI 10.1186/s12872-015-0090-5
   Nutor JJ, 2023, AIDS RES THER, V20, DOI 10.1186/s12981-023-00538-8
   Nyongesa MK, 2021, SUBST ABUSE TREAT PR, V16, DOI 10.1186/s13011-021-00422-6
   Nyongesa MK, 2019, BMC PSYCHIATRY, V19, DOI 10.1186/s12888-019-2339-5
   Obadeji A, 2014, IRAN J PSYCHIATRY BE, V8, P26
   Ogedegbe G, 2010, CARDIOL CLIN, V28, P571, DOI 10.1016/j.ccl.2010.07.006
   Ogunmola OJ, 2014, VASC HEALTH RISK MAN, V10, P129, DOI 10.2147/VHRM.S58449
   Ojong E, 2022, AFR HEALTH SCI, V22, P410, DOI 10.4314/ahs.v22i1.50
   Okello S, 2015, J HYPERTENS, V33, P2039, DOI 10.1097/HJH.0000000000000657
   Okyere J, 2022, BMC PUBLIC HEALTH, V22, DOI 10.1186/s12889-022-14091-y
   Olagunju AT, 2013, AIDS CARE, V25, P1193, DOI 10.1080/09540121.2013.763892
   Olagunju AT, 2012, AIDS BEHAV, V16, P2192, DOI 10.1007/s10461-012-0250-x
   Olisah VO, 2015, INT J PSYCHIAT MED, V48, P253, DOI 10.2190/PM.48.4.b
   Olley Benjamin O, 2006, Afr J AIDS Res, V5, P207, DOI 10.2989/16085900609490381
   Osoti A, 2018, AIDS PATIENT CARE ST, V32, P215, DOI 10.1089/apc.2018.0052
   Ouzzani M, 2016, SYST REV-LONDON, V5, DOI 10.1186/s13643-016-0384-4
   Oyawa I, 2022, PAN AFR MED J, V43, DOI 10.11604/pamj.2022.43.143.36394
   Pambou HOT, 2022, AIMS PUBLIC HEALTH, V9, P490, DOI 10.3934/publichealth.2022034
   Parcesepe AM, 2022, AIDS BEHAV, V26, P651, DOI 10.1007/s10461-021-03425-3
   Patel P, 2018, AIDS, V32, pS5, DOI 10.1097/QAD.0000000000001888
   Peck RN, 2014, BMC MED, V12, DOI 10.1186/s12916-014-0125-2
   Peer Nasheeta, 2015, Trop Dis Travel Med Vaccines, V1, P6, DOI 10.1186/s40794-015-0007-4
   Prattipati S, 2022, GLOB HEART, V17, DOI 10.5334/gh.1127
   Rabkin M, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0140298
   Rajagopaul A, 2021, AFR J PRIM HEALTH CA, V13, DOI 10.4102/phcfm.v13i1.2766
   Rhee JY, 2016, DIABETES-METAB RES, V32, P544, DOI 10.1002/dmrr.2792
   Rohner E, 2017, INT J CANCER, V141, P488, DOI 10.1002/ijc.30749
   Rücker SCM, 2018, AIDS, V32, P253, DOI 10.1097/QAD.0000000000001700
   Ruffieux Y, 2021, CLIN INFECT DIS, V73, pE735, DOI 10.1093/cid/ciab087
   Sander LD, 2015, TROP MED INT HEALTH, V20, P391, DOI 10.1111/tmi.12443
   Sanuade OA, 2021, PAN AFR MED J, V38, DOI 10.11604/pamj.2021.38.317.28335
   Sarfo FS, 2021, HIV MED, V22, P231, DOI 10.1111/hiv.13007
   Sarfo FS, 2019, J CLIN HYPERTENS, V21, P838, DOI 10.1111/jch.13561
   Sarfo FS, 2019, J NEUROL SCI, V397, P103, DOI 10.1016/j.jns.2018.12.026
   Sebilo Motlalepula, 2021, South. Afr. j. HIV med. (Online), V22, P1, DOI 10.4102/sajhivmed.v22i1.1246
   Seid S, 2020, INT J MENT HEALTH SY, V14, DOI 10.1186/s13033-020-00389-0
   Shamu T, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0253000
   Shankalala P, 2017, J DIABETES METAB DIS, V16, DOI 10.1186/s40200-017-0310-x
   Sobieszczyk ME, 2016, JAIDS-J ACQ IMM DEF, V73, P438, DOI 10.1097/QAI.0000000000001123
   Steffen HM, 2023, CLIN RES CARDIOL, V112, P1650, DOI 10.1007/s00392-023-02253-w
   Steiniche D, 2016, T ROY SOC TROP MED H, V110, P219, DOI 10.1093/trstmh/trw017
   Stelzle D, 2021, LANCET GLOB HEALTH, V9, pE161, DOI 10.1016/S2214-109X(20)30459-9
   Stockton MA, 2021, AIDS BEHAV, V25, P826, DOI 10.1007/s10461-020-03041-7
   Tadesse WT, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0262604
   Tareke M, 2018, J AFFECT DISORDERS, V232, P370, DOI 10.1016/j.jad.2018.02.078
   Temu TM, 2015, BMC INFECT DIS, V15, DOI 10.1186/s12879-015-1157-8
   Tesfaw G, 2016, BMC PSYCHIATRY, V16, DOI 10.1186/s12888-016-1037-9
   The Joint United Nations Programme on HIV/AIDS, 2019, UN interagency task force on NCDs, P6
   Tilahun A, 2022, HELIYON, V8, DOI 10.1016/j.heliyon.2022.e11342
   Tilahun H, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000024800
   Todowede OO, 2019, SYST REV-LONDON, V8, DOI 10.1186/s13643-018-0927-y
   Tougouma JB, 2021, PAN AFR MED J, V38, DOI 10.11604/pamj.2021.38.173.9509
   Tsuro U, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph191811196
   Umar DM, 2021, BMC PUBLIC HEALTH, V21, DOI 10.1186/s12889-021-10318-6
   van den Heuvel L, 2013, AIDS CARE, V25, P1527, DOI 10.1080/09540121.2013.793263
   WHO, 2022, Noncommunicable Diseases
   WHO, 2023, Advancing the global agenda on prevention and control of noncommunicable diseases 2000 to 2020: looking forwards to 2030
   Woldeyes E, 2022, MEDICINE, V101, DOI 10.1097/MD.0000000000030081
   Woldeyes E, 2022, HIV AIDS-RES PALLIAT, V14, P297, DOI 10.2147/HIV.S362459
   World Health Organization, 2014, Global action plan for the prevention and control of noncommunicable diseases, 2013-2020
   World Health Organization, 2020, International Federation of Resistance Fighters
   Zelalem W, 2022, FRONT ONCOL, V12, DOI 10.3389/fonc.2022.910915
   Zewudie BT, 2022, SAGE OPEN MED, V10, DOI 10.1177/20503121221094454
   Zewudie Bitew Tefera, 2021, Depress Res Treat, V2021, P8545934, DOI 10.1155/2021/8545934
NR 207
TC 31
Z9 31
U1 0
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2589-5370
J9 ECLINICALMEDICINE
JI EClinicalMedicine
PD NOV
PY 2023
VL 65
AR 102255
DI 10.1016/j.eclinm.2023.102255
EA OCT 2023
PG 26
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA U9WS8
UT WOS:001088244700001
PM 37842552
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Usharani, P
   Merugu, PL
   Nutalapati, C
AF Usharani, Pingali
   Merugu, Padma Latha
   Nutalapati, Chandrasekhar
TI Evaluation of the effects of a standardized aqueous extract of
   Phyllanthus emblica fruits on endothelial dysfunction, oxidative stress,
   systemic inflammation and lipid profile in subjects with metabolic
   syndrome: a randomised, double blind, placebo controlled clinical study
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE Phyllanthus emblica; Emblica officinalis; Amla; Reflection index;
   Dyslipidemia; Oxidative stress; Systemic inflammation; Endothelial
   dysfunction
ID OFFICINALIS GAERTN.; BIOMARKERS; RISK
AB BackgroundEndothelial dysfunction (ED) has been observed in individuals with metabolic syndrome (MetS) and contributes to the initiation and progression of atherosclerosis. The primary management of MetS involves lifestyle modifications and treatment of its individual components with drugs all of which have side effects. Thus, it would be of advantageous if natural products would be used as adjuncts or substitutes for conventional drugs. The aim of the present study was to evaluate the effect of standardized aqueous extract of fruits of Phyllanthus emblica (P. emblica) 250mg and 500mg twice daily on ED, oxidative stress, systemic inflammation and lipid profile in subjects with MetS.MethodsIn this randomised, double-blind, placebo-controlled clinical study endothelial function was measured by calculating reflection index (RI) using digital plethysmograph. Oxidative stress biomarkers used were nitric oxide (NO), glutathione (GSH) and malondialdehyde (MDA). Systemic inflammation was measured by determining high sensitivity C-reactive protein (hsCRP) and dyslipidemia by lipid profile. ANOVA, paired and unpaired t-test were used. P-value <0.05 was considered statistically significant.ResultsOut of 65 screened subjects all 59 enrolled completed the study. P. emblica aqueous extract (PEE), 250mg and 500mg twice daily dosing, showed significant reduction in mean RI, measure of endothelial function, at 8 and 12weeks (p<0.001) compared to baseline and placebo. Significant mean % change was seen in oxidative stress biomarkers, NO (+41.89%, +50.7%), GSH (+24.31%, +53.22%) and MDA (-21.02%, -31.44%), and systemic inflammation biomarker, hsCRP (-39.68%, -53.77%) (p<0.001) at 12weeks with 250mg and 500mg twice daily dosage respectively. Significant mean % change was also seen at 12weeks with TC (-7.71%, -11.11%), HDL-C (+7.33% +22.16%, p<0.05), LDL-C (-11.39%, -21.8%) and TG (-9.81%, -19.22%) respectively with 250mg and 500mg twice daily (p<0.001). PEE 500mg twice daily was significantly more efficacious than the 250mg twice daily and placebo. No participant discontinued the study because of adverse events.ConclusionsP.emblica aqueous extract significantly improved endothelial function, oxidative stress, systemic inflammation and lipid profile at both dosages tested, but especially at 500mg twice daily. Thus, this product may be used as an adjunct to conventional therapy (lifestyle modification and pharmacological intervention) in the management of metabolic syndrome.Trial registrationThis study was registered with Clinical Trials Registry - India (CTRI) with the registration number of CTRI/2017/09/009606. The study was registered retrospectively on 4th September 2017.
C1 [Usharani, Pingali; Merugu, Padma Latha; Nutalapati, Chandrasekhar] Nizams Inst Med Sci, Dept Pharmacol & Therapeut, Hyderabad, Telangana, India.
C3 Nizam's Institute of Medical Sciences
RP Usharani, P (corresponding author), Nizams Inst Med Sci, Dept Pharmacol & Therapeut, Hyderabad, Telangana, India.
EM ushapingali@yahoo.com
CR Akhtar MS, 2011, INT J FOOD SCI NUTR, V62, P609, DOI 10.3109/09637486.2011.560565
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Anderson TJ, 1999, J AM COLL CARDIOL, V34, P631, DOI 10.1016/S0735-1097(99)00259-4
   [Anonymous], 2006, The IDF Consensus Worldwide Definition of the Metabolic Syndrome
   Antony B., 2006, Indian Journal of Pharmaceutical Sciences, V68, P437
   Antony B, 2008, INDIAN J CLIN BIOCHE, V23, P378, DOI 10.1007/s12291-008-0083-6
   Bhandari P. R., 2012, International Journal of Green Pharmacy, V6, P257, DOI 10.4103/0973-8258.108204
   Biswas TK, 2014, J HERB MED, V4, P188, DOI 10.1016/j.hermed.2014.09.002
   Chen TS, 2011, J MED FOOD, V14, P718, DOI 10.1089/jmf.2010.1195
   Chhabra N, 2009, INTERNET J MED UPDAT, V4, P33
   Chowienczyk PJ, 1999, J AM COLL CARDIOL, V34, P2007, DOI 10.1016/S0735-1097(99)00441-6
   Cozma Angela, 2009, Rom J Intern Med, V47, P133
   ELLMAN GL, 1959, ARCH BIOCHEM BIOPHYS, V82, P70, DOI 10.1016/0003-9861(59)90090-6
   Engler MM, 2003, CIRCULATION, V108, P1059, DOI 10.1161/01.CIR.0000086345.09861.A0
   Fujitaka K, 2011, NUTR RES, V31, P842, DOI 10.1016/j.nutres.2011.09.028
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Gupta M.K., 2016, Scholars J Appl Sci, V4, P469
   Halcox JPJ, 2014, J DIABETES METAB, V5, DOI 10.4172/2155-6156.1000362
   Kamath DY, 2015, INDIAN J MED RES, V142, P261, DOI 10.4103/0971-5916.166582
   Khan KH., 2009, BOT RES INT, V2, P218
   Khanna S, 2015, J MED FOOD, V18, P415, DOI 10.1089/jmf.2014.0178
   Kim HY, 2010, BRIT J NUTR, V103, P502, DOI 10.1017/S0007114509991978
   Kishore K.K., 2016, EUR J BIOMED PHARM S, V3, P181
   Yubero-Serrano EM, 2013, EXP MOL MED, V45, DOI 10.1038/emm.2013.53
   Millasseau SC, 2002, CLIN SCI, V103, P371, DOI 10.1042/cs1030371
   Miranda KM, 2001, NITRIC OXIDE-BIOL CH, V5, P62, DOI 10.1006/niox.2000.0319
   Naidu MUR, 2007, INDIAN J PHARMACOL, V39, P168, DOI 10.4103/0253-7613.33439
   Rambaran C, 2008, BRIT J CLIN PHARMACO, V65, P238, DOI 10.1111/j.1365-2125.2007.03006.x
   Srikanthan K, 2016, INT J MED SCI, V13, P25, DOI 10.7150/ijms.13800
   Usharani P, 2014, INT J PHARM SCI RES, V5, P2687, DOI 10.13040/IJPSR.0975-8232.5(6).2687-97
   Usharani P, 2013, DIABET METAB SYND OB, V6, P275, DOI 10.2147/DMSO.S46341
   Van Guilder GP, 2006, OBESITY, V14, P2127, DOI 10.1038/oby.2006.248
   Versari D, 2009, DIABETES CARE, V32, pS314, DOI 10.2337/dc09-S330
   Vidyasagar J., 2004, Indian Journal of Pharmacology, V36, P76
NR 34
TC 37
Z9 42
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD MAY 6
PY 2019
VL 19
AR 97
DI 10.1186/s12906-019-2509-5
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA HX2HQ
UT WOS:000467213300002
PM 31060549
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dearing, C
   Handa, RJ
   Myers, B
AF Dearing, Carley
   Handa, Robert J.
   Myers, Brent
TI Sex differences in autonomic responses to stress: implications for
   cardiometabolic physiology
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE androgen; autonomic balance; chronic stress; estrogen; glucocorticoid
ID ESTROGEN-RECEPTOR-ALPHA; CORTICOTROPIN-RELEASING HORMONE; MAJOR
   DEPRESSIVE DISORDER; SOCIOECONOMIC-STATUS; FEMALE RATS; PARAVENTRICULAR
   NUCLEUS; VASCULAR DYSFUNCTION; METABOLIC SYNDROME; ANDROGEN RECEPTOR;
   ALLOSTATIC LOAD
AB Chronic stress is a significant risk factor for negative health outcomes. Furthermore, imbalance of autonomic nervous system control leads to dysregulation of physiological responses to stress and contributes to the pathogenesis of cardiometabolic and psychiatric disorders. However, research on autonomic stress responses has historically focused on males, despite evidence that females are disproportionality affected by stress-related disorders. Accordingly, this mini-review focuses on the influence of biological sex on autonomic responses to stress in humans and rodent models. The reviewed literature points to sex differences in the consequences of chronic stress, including cardiovascular and metabolic disease. We also explore basic rodent studies of sex-specific autonomic responses to stress with a focus on sex hormones and hypothalamic-pituitary-adrenal axis regulation of cardiovascular and metabolic physiology. Ultimately, emerging evidence of sex differences in autonomic-endocrine integration highlights the importance of sex-specific studies to understand and treat cardiometabolic dysfunction.
C1 [Dearing, Carley; Handa, Robert J.; Myers, Brent] Colorado State Univ, Dept Biomed Sci, Ft Collins, CO 80523 USA.
C3 Colorado State University System; Colorado State University Fort Collins
RP Myers, B (corresponding author), Colorado State Univ, Dept Biomed Sci, Ft Collins, CO 80523 USA.
EM brent.myers@colostate.edu
FU NIH [F30 OD032120, R01 DK105826, R01 HL150559]
FX GRANTS This study was supported by NIH grants F30 OD032120 (to C.D.) ,
   R01 DK105826 (to R.J.H.) , and R01 HL150559 (to B.M.) .
CR Adam EK, 2017, PSYCHONEUROENDOCRINO, V83, P25, DOI 10.1016/j.psyneuen.2017.05.018
   Algren MH, 2018, BMC PUBLIC HEALTH, V18, DOI 10.1186/s12889-018-5170-x
   Anand SS, 2003, CIRCULATION, V108, P420, DOI 10.1161/01.CIR.0000080884.27358.49
   Arias-Loza PA, 2008, GENDER MED, V5, pS34, DOI 10.1016/j.genm.2008.03.005
   Arun S, 2016, INT J REPROD BIOMED, V14, P443
   Avan A, 2019, BMC MED, V17, DOI 10.1186/s12916-019-1397-3
   Bao AM, 2006, MOL PSYCHIATR, V11, P567, DOI 10.1038/sj.mp.4001800
   Barnard DF, 2019, PSYCHONEUROENDOCRINO, V103, P203, DOI 10.1016/j.psyneuen.2019.01.026
   Bekhbat M, 2019, BRAIN BEHAV IMMUN, V76, P248, DOI 10.1016/j.bbi.2018.12.005
   Brahmbhatt Y, 2019, CURR HYPERTENS REP, V21, DOI 10.1007/s11906-019-0979-y
   Brailoiu E, 2007, J ENDOCRINOL, V193, P311, DOI 10.1677/JOE-07-0017
   Brockbank CL, 2000, EXP PHYSIOL, V85, P327
   Brooks SD, 2018, AM J PHYSIOL-HEART C, V314, pH1070, DOI 10.1152/ajpheart.00647.2017
   Broughton BRS, 2010, AM J PHYSIOL-HEART C, V298, pH1055, DOI 10.1152/ajpheart.00878.2009
   Burt VK, 2002, J CLIN PSYCHIAT, V63, P9
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Chen CM, 2019, ONCOL LETT, V18, P5673, DOI 10.3892/ol.2019.10983
   Cho JJ, 2003, MED SCI MONIT, V9, P63
   CHROUSOS GP, 1992, JAMA-J AM MED ASSOC, V267, P1244, DOI 10.1001/jama.267.9.1244
   Cohen S, 2006, PSYCHOSOM MED, V68, P41, DOI 10.1097/01.psy.0000195967.51768.ea
   Contoreggi NH, 2021, J COMP NEUROL, V529, P2283, DOI 10.1002/cne.25093
   Coolen RL, 2021, J ANAT, V239, P125, DOI 10.1111/joa.13407
   Cotella EM, 2020, PSYCHONEUROENDOCRINO, V112, DOI 10.1016/j.psyneuen.2019.104490
   Davis SR, 2020, J CLIN ENDOCR METAB, V105, pE3348, DOI 10.1210/clinem/dgaa429
   Dearing Carley, 2021, Horm Behav, V136, P105060, DOI 10.1016/j.yhbeh.2021.105060
   Dhabhar FS, 2019, STRESS, V22, P526, DOI 10.1080/10253890.2019.1634049
   Evans AN, 2013, MOL ENDOCRINOL, V27, P1796, DOI 10.1210/me.2013-1095
   Falvey A, 2020, J NEUROINFLAMM, V17, DOI 10.1186/s12974-020-02016-8
   Farah VMA, 2004, PHYSIOL BEHAV, V83, P135, DOI 10.1016/j.physbeh.2004.08.004
   Faulkner JL, 2019, CURR HYPERTENS REP, V21, DOI 10.1007/s11906-019-0981-4
   Ferreira M, 2020, BIOL SEX DIFFER, V11, DOI 10.1186/s13293-020-00290-y
   Fiksdal A, 2019, PSYCHONEUROENDOCRINO, V102, P44, DOI 10.1016/j.psyneuen.2018.11.035
   Finnell JE, 2018, BIOL PSYCHIAT, V84, P372, DOI 10.1016/j.biopsych.2018.01.013
   Finnell JE, 2016, NEUROBIOL STRESS, V4, P1, DOI 10.1016/j.ynstr.2016.04.001
   Focke CMB, 2020, MOL CELL ENDOCRINOL, V501, DOI 10.1016/j.mce.2019.110652
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Garrett JE, 2009, NEUROSCIENCE, V162, P195, DOI 10.1016/j.neuroscience.2009.04.057
   Ghimire A, 2020, EXP GERONTOL, V141, DOI 10.1016/j.exger.2020.111093
   Goldstein JM, 2019, NEUROPSYCHOPHARMACOL, V44, P59, DOI 10.1038/s41386-018-0146-1
   Goshen I, 2008, MOL PSYCHIATR, V13, P717, DOI 10.1038/sj.mp.4002055
   Graves Katelyn Y, 2017, Glob Pediatr Health, V4, p2333794X17744950, DOI 10.1177/2333794X17744950
   Gros R, 2013, AM J PHYSIOL-CELL PH, V304, pC532, DOI 10.1152/ajpcell.00203.2012
   Guo L, 2018, PSYCHONEUROENDOCRINO, V95, P34, DOI 10.1016/j.psyneuen.2018.05.016
   Han F, 2005, NEUROSCI RES, V51, P371, DOI 10.1016/j.neures.2004.12.013
   Han K, 2019, J NEUROSCI, V39, P10081, DOI 10.1523/JNEUROSCI.1357-19.2019
   Handa RJ, 2014, FRONT NEUROENDOCRIN, V35, P197, DOI 10.1016/j.yfrne.2013.11.001
   Handa RJ, 2012, NEUROENDOCRINOLOGY, V96, P111, DOI 10.1159/000338397
   Hanson AE, 2020, BIOL SEX DIFFER, V11, DOI 10.1186/s13293-020-00324-5
   Herman JP, 2016, COMPR PHYSIOL, V6, P603, DOI 10.1002/cphy.c150015
   Hostinar CE, 2017, PSYCHOSOM MED, V79, P514, DOI 10.1097/PSY.0000000000000455
   Hu P, 2016, ENDOCRINOLOGY, V157, P3604, DOI 10.1210/en.2016-1191
   Hutson DD, 2019, BIOL SEX DIFFER, V10, DOI 10.1186/s13293-019-0219-9
   Ikeda K, 2019, J STEROID BIOCHEM, V191, DOI 10.1016/j.jsbmb.2019.105375
   Isfort M, 2014, HEART FAIL REV, V19, P35, DOI 10.1007/s10741-013-9377-8
   JACOBSON L, 1991, ENDOCR REV, V12, P118, DOI 10.1210/edrv-12-2-118
   Joseph V, 2006, BRAIN RES, V1073, P71, DOI 10.1016/j.brainres.2005.12.075
   Joyner MJ, 2016, EXP PHYSIOL, V101, P349, DOI 10.1113/EP085146
   Kappus RM, 2015, BIOL SEX DIFFER, V6, DOI 10.1186/s13293-015-0046-6
   Karisetty BC, 2017, NEUROSCIENCE, V356, P89, DOI 10.1016/j.neuroscience.2017.05.020
   Keller-Wood M, 2015, COMPR PHYSIOL, V5, P1161, DOI 10.1002/cphy.c140065
   Kessler RC, 2003, JAMA-J AM MED ASSOC, V289, P3095, DOI 10.1001/jama.289.23.3095
   Köhler O, 2016, CURR NEUROPHARMACOL, V14, P732, DOI 10.2174/1570159X14666151208113700
   KORNEL L, 1993, STEROIDS, V58, P580, DOI 10.1016/0039-128X(93)90099-9
   Lagranha CJ, 2018, LIFE SCI, V192, P190, DOI 10.1016/j.lfs.2017.11.043
   Langellier BA, 2021, AM J PREV MED, V60, P159, DOI 10.1016/j.amepre.2020.08.022
   Leonard BE, 2018, ACTA NEUROPSYCHIATR, V30, P1, DOI 10.1017/neu.2016.69
   Li WJ, 2018, BIOCHEM BIOPH RES CO, V503, P2543, DOI 10.1016/j.bbrc.2018.07.013
   Liu R, 2013, BRAIN RES, V1514, P83, DOI 10.1016/j.brainres.2013.01.023
   Liu SB, 2013, BRAIN RES BULL, V93, P27, DOI 10.1016/j.brainresbull.2012.10.004
   Lizotte E, 2009, CELL PHYSIOL BIOCHEM, V23, P75, DOI 10.1159/000204096
   LOMBES M, 1992, CIRC RES, V71, P503, DOI 10.1161/01.RES.71.3.503
   Maejima Y, 2009, VET J, V181, P193, DOI 10.1016/j.tvjl.2008.02.021
   Mahmoodzadeh S, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00310
   Mann V, 2007, BONE, V40, P674, DOI 10.1016/j.bone.2006.10.014
   Manoranjan B, 2010, ANTICANCER RES, V30, P2897
   McCorry LK, 2007, AM J PHARM EDUC, V71, DOI 10.5688/aj710478
   McIntyre RS, 2009, CURR DIABETES REP, V9, P51, DOI 10.1007/s11892-009-0010-0
   Mendelsohn ME, 1999, NEW ENGL J MED, V340, P1801, DOI 10.1056/NEJM199906103402306
   Moretti C, 2017, CURR HYPERTENS REP, V19, DOI 10.1007/s11906-017-0740-3
   Morford J, 2016, DIALOGUES CLIN NEURO, V18, P415
   Myers B, 2017, PHYSIOL BEHAV, V172, P49, DOI 10.1016/j.physbeh.2016.10.015
   Myers B, 2014, FRONT NEUROENDOCRIN, V35, P180, DOI 10.1016/j.yfrne.2013.12.003
   Myers B, 2012, CELL MOL NEUROBIOL, V32, P683, DOI 10.1007/s10571-012-9801-y
   Nahman-Averbuch H, 2016, PHYSIOL BEHAV, V154, P40, DOI 10.1016/j.physbeh.2015.11.004
   Oakley RH, 2019, SCI SIGNAL, V12, DOI 10.1126/scisignal.aau9685
   Oliveira LA, 2021, PROG NEURO-PSYCHOPH, V105, DOI 10.1016/j.pnpbp.2020.110009
   Perusquía M, 2019, ENDOCRINE, V65, P416, DOI 10.1007/s12020-019-01978-x
   Pervanidou P, 2011, INT J PEDIATR OBES, V6, P21, DOI 10.3109/17477166.2011.615996
   Petrie JR, 2018, CAN J CARDIOL, V34, P575, DOI 10.1016/j.cjca.2017.12.005
   Picard M, 2014, NAT REV ENDOCRINOL, V10, P303, DOI 10.1038/nrendo.2014.22
   Qu N, 2020, J ALZHEIMERS DIS, V77, P1077, DOI 10.3233/JAD-200486
   Rodgers JL, 2019, J CARDIOVASC DEV DIS, V6, DOI 10.3390/jcdd6020019
   Rosamond W, 2007, CIRCULATION, V115, pE69, DOI 10.1161/CIRCULATIONAHA.106.179918
   Rosinger ZJ, 2019, J COMP NEUROL, V527, P1056, DOI 10.1002/cne.24588
   Sabbatini AR, 2020, BIOL SEX DIFFER, V11, DOI 10.1186/s13293-020-00306-7
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Saleh MC, 2000, BRAIN RES, V879, P105, DOI 10.1016/S0006-8993(00)02757-8
   Schlenker EH, 2006, BRAIN RES, V1123, P89, DOI 10.1016/j.brainres.2006.09.035
   Schmeer KK, 2016, ARCH DIS CHILD, V101, P1043, DOI 10.1136/archdischild-2016-310837
   Sgoifo A, 2014, NEUROSCI BIOBEHAV R, V39, P51, DOI 10.1016/j.neubiorev.2013.12.005
   Shen HL, 2012, INT J NEUROPSYCHOPH, V15, P523, DOI 10.1017/S1461145711000708
   Sheng JA, 2021, FRONT BEHAV NEUROSCI, V14, DOI 10.3389/fnbeh.2020.601939
   Firmino EMS, 2019, J EXP BIOL, V222, DOI 10.1242/jeb.204883
   Stanley SC, 2014, J APPL PHYSIOL, V117, P959, DOI 10.1152/japplphysiol.00537.2014
   Starr LR, 2019, PSYCHONEUROENDOCRINO, V100, P156, DOI 10.1016/j.psyneuen.2018.10.003
   Steagall RJ, 2017, LIFE SCI, V182, P41, DOI 10.1016/j.lfs.2017.06.005
   Stringhini S, 2015, INT J EPIDEMIOL, V44, P1320, DOI 10.1093/ije/dyv060
   Sudheimer K, 2015, NEUROPSYCHOPHARMACOL, V40, P849, DOI 10.1038/npp.2014.259
   Sullivan AD, 2019, J FAM PSYCHOL, V33, P883, DOI 10.1037/fam0000567
   Tank AW, 2015, COMPR PHYSIOL, V5, P1, DOI 10.1002/cphy.c140007
   Taraborrelli S, 2015, ACTA OBSTET GYN SCAN, V94, P8, DOI 10.1111/aogs.12771
   Trejter M, 2015, FOLIA HISTOCHEM CYTO, V53, P133, DOI 10.5603/FHC.a2015.0012
   Ulrich-Lai YM, 2006, AM J PHYSIOL-ENDOC M, V291, pE965, DOI 10.1152/ajpendo.00070.2006
   Ursache A, 2017, PSYCHONEUROENDOCRINO, V78, P142, DOI 10.1016/j.psyneuen.2017.01.020
   Vanderhorst VGJM, 2009, NEUROSCIENCE, V158, P798, DOI 10.1016/j.neuroscience.2008.10.017
   VIAU V, 1991, ENDOCRINOLOGY, V129, P2503, DOI 10.1210/endo-129-5-2503
   Viau V, 1996, J NEUROSCI, V16, P1866
   Vieira JO, 2018, PROG NEURO-PSYCHOPH, V81, P426, DOI 10.1016/j.pnpbp.2017.08.014
   Virtanen I, 2000, MATURITAS, V37, P45, DOI 10.1016/S0378-5122(00)00162-6
   vom Berg-Maurer CM, 2016, J NEUROSCI, V36, P3350, DOI 10.1523/JNEUROSCI.3390-15.2016
   Wainwright SR, 2016, HORM BEHAV, V79, P58, DOI 10.1016/j.yhbeh.2016.01.001
   Wallace T, 2021, PSYCHONEUROENDOCRINO, V129, DOI 10.1016/j.psyneuen.2021.105238
   Wang YL, 2018, J NEUROINFLAMM, V15, DOI 10.1186/s12974-018-1054-3
   Wei J, 2014, MOL PSYCHIATR, V19, P588, DOI 10.1038/mp.2013.83
   Williams J, 2018, J GLOB HEALTH, V8, DOI 10.7189/jogh.08.020409
   Wulsin AC, 2016, PSYCHONEUROENDOCRINO, V65, P109, DOI 10.1016/j.psyneuen.2015.12.004
   Xue BJ, 2013, HYPERTENSION, V61, P1255, DOI 10.1161/HYPERTENSIONAHA.111.00903
   Yan Y, 2018, NEUROBIOL STRESS, V8, P120, DOI 10.1016/j.ynstr.2018.03.002
   Yang SG, 2013, PHYSIOL RES, V62, pS165, DOI 10.33549/physiolres.932612
   Yeap BB, 2010, CURR OPIN ENDOCRINOL, V17, P269, DOI 10.1097/MED.0b013e3283383031
   Young WJ, 1998, ENDOCRINE, V9, P79, DOI 10.1385/ENDO:9:1:79
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
   Zeng X, 2020, CLIN CHIM ACTA, V502, P214, DOI 10.1016/j.cca.2019.11.003
   Zhao ZJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0075513
   Zhou ZQ, 2018, J BIOL CHEM, V293, P4735, DOI 10.1074/jbc.M117.805069
   Zoubina EV, 2002, J NEUROBIOL, V52, P14, DOI 10.1002/neu.10064
NR 136
TC 18
Z9 20
U1 2
U2 7
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD SEP
PY 2022
VL 323
IS 3
BP E281
EP E289
DI 10.1152/ajpendo.00058.2022
PG 9
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 6S3FO
UT WOS:000892877100008
PM 35793480
OA Green Published
DA 2025-06-11
ER

PT J
AU Mulero, J
   Zafrilla, P
   Martinez-Cacha, A
AF Mulero, J.
   Zafrilla, P.
   Martinez-Cacha, A.
TI Oxidative stress, frailty and cognitive decline
SO JOURNAL OF NUTRITION HEALTH & AGING
LA English
DT Article
DE Frailty; oxidative stress; decline cognitive
ID OLDER MEXICAN-AMERICANS; ALZHEIMERS-DISEASE; CARDIOVASCULAR HEALTH;
   METABOLIC SYNDROME; GENE-EXPRESSION; BRAIN; INFLAMMATION; INTERLEUKIN-6;
   MARKERS; ADULTS
AB The causes of frailty are complex and must be accepted as multidimensional based on the interplay of genetic, biological, physical, psychological, social and environmental factors, although inflammation and oxidative stress are two factors that play an important role in the development of symptoms with those fragile states.
   To establish the relationship between oxidative stress, frailty and decline cognitive.
   A review of the literature and data abstraction from papers are showing the relationship between a) oxidative stress and frailty, b) oxidative stress and decline cognitive.
   The papers reviewed showed that we can establish a relationship between the progress of neurodegenerative disorders and increased oxidative stress. Also found in frailty, that oxidative stress plays an important role as one of the starting points for the appearance of permanent inflammatory states.
   Although the literature indicates the relationship between oxidative stress, frailty and decline cognitive, more studies are needed in this regard, especially interventions that asses whether increased intake of antioxidants in older frailty may improve the progress of disease and slow cognitive decline.
C1 [Mulero, J.; Zafrilla, P.; Martinez-Cacha, A.] Catholic Univ San Antonio, Dept Food Technol & Nutr, Murcia 30107, Spain.
C3 Universidad Catolica de Murcia
RP Mulero, J (corresponding author), Catholic Univ San Antonio, Dept Food Technol & Nutr, Murcia 30107, Spain.
EM jmulero@pdi.ucam.edu
RI Zafrilla, Pilar/JAN-5983-2023
OI ZAFRILLA, PILAR/0000-0002-1463-7120
CR Balaban RS, 2005, CELL, V120, P483, DOI 10.1016/j.cell.2005.02.001
   Bandeen-Roche K, 2009, REJUV RES, V12, P403, DOI 10.1089/rej.2009.0883
   Barzilay JI, 2007, ARCH INTERN MED, V167, P635, DOI 10.1001/archinte.167.7.635
   Bergman H, 2007, J GERONTOL A-BIOL, V62, P731, DOI 10.1093/gerona/62.7.731
   Ble A, 2006, J GERONTOL A-BIOL, V61, P278, DOI 10.1093/gerona/61.3.278
   Buchman AS, 2007, PSYCHOSOM MED, V69, P483, DOI 10.1097/psy.0b013e318068de1d
   Carter CS, 2007, APPL PHYSIOL NUTR ME, V32, P954, DOI 10.1139/H07-085
   Cesari M, 2004, J GERONTOL A-BIOL, V59, P242
   Christensen K, 2008, P NATL ACAD SCI USA, V105, P13274, DOI 10.1073/pnas.0804931105
   Després JP, 2008, ARTERIOSCL THROM VAS, V28, P1039, DOI 10.1161/ATVBAHA.107.159228
   Dröge W, 2007, AGING CELL, V6, P361, DOI 10.1111/j.1474-9726.2007.00294.x
   El Mohsen MMA, 2005, BIOCHEM BIOPH RES CO, V336, P386, DOI 10.1016/j.bbrc.2005.07.201
   Ershler WB, 2000, ANNU REV MED, V51, P245, DOI 10.1146/annurev.med.51.1.245
   Espinoza S, 2005, CLEV CLIN J MED, V72, P1105, DOI 10.3949/ccjm.72.12.1105
   Ferrucci L, 1999, J AM GERIATR SOC, V47, P639, DOI 10.1111/j.1532-5415.1999.tb01583.x
   Franceschi C, 2007, MECH AGEING DEV, V128, P92, DOI 10.1016/j.mad.2006.11.016
   Fraser HB, 2005, PLOS BIOL, V3, P1653, DOI 10.1371/journal.pbio.0030274
   Fried LP, 2001, J GERONTOL A-BIOL, V56, pM146, DOI 10.1093/gerona/56.3.M146
   Fried LP., 2003, PRINCIPLES GERIATRIC, V5, P1487
   Fulop T, 2006, PATHOL BIOL, V54, P375, DOI 10.1016/j.patbio.2006.07.002
   Fulop T, 2010, BIOGERONTOLOGY, V11, P547, DOI 10.1007/s10522-010-9287-2
   Gallagher M, 1996, SCIENCE, V274, P484, DOI 10.1126/science.274.5287.484
   Giorgio M, 2007, NAT REV MOL CELL BIO, V8, p722A
   Howard C, 2007, J APPL PHYSIOL, V103, P17, DOI 10.1152/japplphysiol.00133.2007
   Hunt KJ, 2010, BIOL RES NURS, V11, P245, DOI 10.1177/1099800409352237
   Joseph JA, 2005, NEUROCHEM RES, V30, P927, DOI 10.1007/s11064-005-6967-4
   Kanapuru B, 2009, AM J MED, V122, P605, DOI 10.1016/j.amjmed.2009.01.030
   Kowaltowski AJ, 2001, FEBS LETT, V495, P12, DOI 10.1016/S0014-5793(01)02316-X
   Kregel KC, 2007, AM J PHYSIOL-REG I, V292, pR18, DOI 10.1152/ajpregu.00327.2006
   Leng SX, 2007, J AM GERIATR SOC, V55, P864, DOI 10.1111/j.1532-5415.2007.01186.x
   Levers MJ, 2006, J ADV NURS, V56, P282, DOI 10.1111/j.1365-2648.2006.04021.x
   Lin MT, 2006, NATURE, V443, P787, DOI 10.1038/nature05292
   Liu RL, 2003, P NATL ACAD SCI USA, V100, P8526, DOI 10.1073/pnas.1332809100
   Maggio M, 2006, J GERONTOL A-BIOL, V61, P575, DOI 10.1093/gerona/61.6.575
   Mighore L, 2005, NEUROBIOL AGING, V26, P567, DOI 10.1016/j.neurobiolaging.2004.07.016
   Montesanto A, 2010, AGE, V32, P385, DOI 10.1007/s11357-010-9136-x
   Muller FL, 2007, FREE RADICAL BIO MED, V43, P477, DOI 10.1016/j.freeradbiomed.2007.03.034
   Navarro A, 2004, AM J PHYSIOL-REG I, V286, pR505, DOI 10.1152/ajpregu.00208.2003
   Ottenbacher KJ, 2005, J AM GERIATR SOC, V53, P1524, DOI 10.1111/j.1532-5415.2005.53511.x
   Paravicini TM, 2006, CARDIOVASC RES, V71, P247, DOI 10.1016/j.cardiores.2006.05.001
   Park DC, 2009, ANNU REV PSYCHOL, V60, P173, DOI 10.1146/annurev.psych.59.103006.093656
   Poon HF, 2006, ANTIOXID REDOX SIGN, V8, P381, DOI 10.1089/ars.2006.8.381
   Pou KM, 2007, CIRCULATION, V116, P1234, DOI 10.1161/CIRCULATIONAHA.107.710509
   Praticò D, 2002, ARCH NEUROL-CHICAGO, V59, P972, DOI 10.1001/archneur.59.6.972
   Reid MB, 2001, RESP RES, V2, P269, DOI 10.1186/rr67
   Richwine AF, 2005, BRAIN BEHAV IMMUN, V19, P512, DOI 10.1016/j.bbi.2004.12.005
   Rinaldi P, 2003, NEUROBIOL AGING, V24, P915, DOI 10.1016/S0197-4580(03)00031-9
   Rockwood K, 2007, J GERONTOL A-BIOL, V62, P722, DOI 10.1093/gerona/62.7.722
   Samper-Ternent R, 2008, J AM GERIATR SOC, V56, P1845, DOI 10.1111/j.1532-5415.2008.01947.x
   Scarmeas N, 2009, JAMA-J AM MED ASSOC, V302, P2431, DOI 10.1001/jama.2009.1791
   SCHUTT A, 1999, BRAIN FUNCTION OSCIL, V2, P91
   Serviddio G, 2009, INT J IMMUNOPATH PH, V22, P819, DOI 10.1177/039463200902200328
   Siqueira IR, 2005, LIFE SCI, V78, P271, DOI 10.1016/j.lfs.2005.04.044
   Trujillo ME, 2006, ENDOCR REV, V27, P798, DOI 10.1210/er.2006-0033
   Wallace DC, 1999, SCIENCE, V283, P1482, DOI 10.1126/science.283.5407.1482
   Walston J, 2002, ARCH INTERN MED, V162, P2333, DOI 10.1001/archinte.162.20.2333
   Walston J, 2006, J AM GERIATR SOC, V54, P991, DOI 10.1111/j.1532-5415.2006.00745.x
   Wang J, 2005, J NEUROCHEM, V93, P953, DOI 10.1111/j.1471-4159.2005.03053.x
   Wolf H, 2004, NEUROBIOL AGING, V25, P913, DOI 10.1016/j.neurobiolaging.2003.08.006
   Wu IC, 2009, J AM GERIATR SOC, V57, P1666, DOI 10.1111/j.1532-5415.2009.02392.x
   Yankner BA, 2008, ANNU REV PATHOL-MECH, V3, P41, DOI 10.1146/annurev.pathmechdis.2.010506.092044
NR 61
TC 125
Z9 134
U1 0
U2 40
PU SPRINGER FRANCE
PI PARIS
PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE
SN 1279-7707
EI 1760-4788
J9 J NUTR HEALTH AGING
JI J. Nutr. Health Aging
PD NOV
PY 2011
VL 15
IS 9
BP 756
EP 760
DI 10.1007/s12603-011-0130-5
PG 5
WC Geriatrics & Gerontology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Nutrition & Dietetics
GA 856US
UT WOS:000297669700004
PM 22089224
OA hybrid
DA 2025-06-11
ER

PT J
AU Wan, C
   Su, H
   Zhang, C
AF Wan, Cheng
   Su, Hua
   Zhang, Chun
TI Role of NADPH Oxidase in Metabolic Disease-Related Renal Injury: An
   Update
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID CHRONIC KIDNEY-DISEASE; OXYGEN SPECIES PRODUCTION; OXIDATIVE STRESS;
   ANGIOTENSIN-II; URIC-ACID; ENDOTHELIAL DYSFUNCTION; GLOMERULAR INJURY;
   PODOCYTE INJURY; HIGH GLUCOSE; FIBRONECTIN EXPRESSION
AB Metabolic syndrome has been linked to an increased risk of chronic kidney disease. The underlying pathogenesis of metabolic disease-related renal injury remains obscure. Accumulating evidence has shown that NADPH oxidase is a major source of intrarenal oxidative stress and is upregulated by metabolic factors leading to overproduction of ROS in podocytes, endothelial cells, and mesangial cells in glomeruli, which is closely associated with the initiation and progression of glomerular diseases. This review focuses on the role of NADPH oxidase-induced oxidative stress in the pathogenesis of metabolic disease-related renal injury. Understanding of the mechanism may help find potential therapeutic strategies.
C1 [Wan, Cheng; Su, Hua; Zhang, Chun] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Nephrol, Wuhan 430022, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology
RP Zhang, C (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Nephrol, Wuhan 430022, Hubei, Peoples R China.
EM drzhangchun@hust.edu.cn
RI ZHANG, CHUN/HLH-6523-2023
OI Zhang, Chun/0000-0003-3565-8024
FU National Natural Science Foundation of China [81170662, 31200872,
   81470964, 81570671, 81522010]; Wuhan Science and Technology Bureau
   [2015060101010039]; Specialized Research Fund for the Doctoral Program
   of Higher Education of China [20130142110064]
FX This work was supported by grants from the National Natural Science
   Foundation of China (no. 81170662, no. 31200872, no. 81470964, no.
   81570671, and no. 81522010), a grant from Wuhan Science and Technology
   Bureau (no. 2015060101010039), and Specialized Research Fund for the
   Doctoral Program of Higher Education of China (no. 20130142110064).
CR Abais JM, 2013, ANTIOXID REDOX SIGN, V18, P1537, DOI 10.1089/ars.2012.4666
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Anderson S, 1989, Am J Med, V87, p34N
   Asaba K, 2005, KIDNEY INT, V67, P1890, DOI 10.1111/j.1523-1755.2005.00287.x
   Barnes JL, 2011, KIDNEY INT, V79, P944, DOI 10.1038/ki.2010.516
   Bedard K, 2007, PHYSIOL REV, V87, P245, DOI 10.1152/physrev.00044.2005
   Block K, 2008, J BIOL CHEM, V283, P24061, DOI 10.1074/jbc.M803964200
   Bondi CD, 2010, J AM SOC NEPHROL, V21, P93, DOI 10.1681/ASN.2009020146
   Cai H, 2000, CIRC RES, V87, P840, DOI 10.1161/01.RES.87.10.840
   Campbell KN, 2011, CURR DIABETES REV, V7, P3, DOI 10.2174/157339911794273973
   Chen J, 2003, J AM SOC NEPHROL, V14, P469, DOI 10.1097/01.ASN.0000046029.53933.09
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Chen J, 2007, NEPHROL DIAL TRANSPL, V22, P1100, DOI 10.1093/ndt/gfl759
   Chen S, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/839761
   Chow K, 1999, CLIN EXP PHARMACOL P, V26, P817, DOI 10.1046/j.1440-1681.1999.03133.x
   Darouich S, 2011, ULTRASTRUCT PATHOL, V35, P176, DOI 10.3109/01913123.2011.584657
   Das R, 2014, AM J PHYSIOL-RENAL, V306, pF155, DOI 10.1152/ajprenal.00438.2013
   Dennis VW, 1996, KIDNEY INT, V50, pS11
   Diamond J R, 1989, Am J Med, V87, p25N
   Dousdampanis P, 2014, RENAL FAILURE, V36, P1351, DOI 10.3109/0886022X.2014.947516
   Eid AA, 2010, J BIOL CHEM, V285, P37503, DOI 10.1074/jbc.M110.136796
   Eid AA, 2009, DIABETES, V58, P1201, DOI 10.2337/db08-1536
   Erol A, 2007, ENDOTHELIUM-J ENDOTH, V14, P157, DOI 10.1080/10623320701421487
   Etoh T, 2003, DIABETOLOGIA, V46, P1428, DOI 10.1007/s00125-003-1205-6
   Fujii M, 2007, KIDNEY INT, V72, P473, DOI 10.1038/sj.ki.5002366
   Gill PS, 2006, ANTIOXID REDOX SIGN, V8, P1597, DOI 10.1089/ars.2006.8.1597
   Glantzounis GK, 2005, CURR PHARM DESIGN, V11, P4145, DOI 10.2174/138161205774913255
   Gorin Y, 2005, J BIOL CHEM, V280, P39616, DOI 10.1074/jbc.M502412200
   Gorin Y, 2004, BIOCHEM J, V381, P231, DOI 10.1042/BJ20031614
   Gorin Y, 2003, AM J PHYSIOL-RENAL, V285, pF219, DOI 10.1152/ajprenal.00414.2002
   Gorin Y, 2015, AM J PHYSIOL-RENAL, V308, pF1276, DOI 10.1152/ajprenal.00396.2014
   Gorin Y, 2015, MOL CELLS, V38, P285, DOI 10.14348/molcells.2015.0010
   Gorin Y, 2013, FREE RADICAL BIO MED, V61, P130, DOI 10.1016/j.freeradbiomed.2013.03.014
   Gorin Y, 2013, CLIN SCI, V125, P361, DOI 10.1042/CS20130065
   Greiber S, 1998, KIDNEY INT, V53, P654, DOI 10.1046/j.1523-1755.1998.00796.x
   Guo HY, 2007, CAN J CARDIOL, V23, P275, DOI 10.1016/S0828-282X(07)70754-7
   Gupta A, 1997, J NEPHROL, V10, P77
   Habibi J, 2011, ENDOCRINOLOGY, V152, P659, DOI 10.1210/en.2010-1038
   Hakim FA, 2010, MED SCI MONITOR, V16, pRA37
   He L, 2015, BMC NEPHROL, V16, DOI 10.1186/s12882-015-0041-5
   Ho WJ, 2010, RHEUMATOLOGY, V49, P1929, DOI 10.1093/rheumatology/keq184
   Hoehner CM, 2002, J AM SOC NEPHROL, V13, DOI 10.1097/01.ASN.0000015762.92814.85
   Ingram AJ, 2004, KIDNEY INT, V66, P733, DOI 10.1111/j.1523-1755.2004.00795.x
   Jha JC, 2014, J AM SOC NEPHROL, V25, P1237, DOI 10.1681/ASN.2013070810
   Johnson RJ, 2003, HYPERTENSION, V41, P1183, DOI 10.1161/01.HYP.0000069700.62727.C5
   Joles JA, 2000, J AM SOC NEPHROL, V11, P669, DOI 10.1681/ASN.V114669
   JONES SA, 1995, J AM SOC NEPHROL, V5, P1483
   Kamanna VS, 1998, HISTOL HISTOPATHOL, V13, P169, DOI 10.14670/HH-13.169
   Kang DH, 2005, SEMIN NEPHROL, V25, P43, DOI 10.1016/j.semnephrol.2004.10.001
   Kang Duk-Hee, 2014, Electrolyte Blood Press, V12, P1, DOI 10.5049/EBP.2014.12.1.1
   Kanwar YS, 2011, ANNU REV PATHOL-MECH, V6, P395, DOI 10.1146/annurev.pathol.4.110807.092150
   KASISKE BL, 1988, CIRC RES, V62, P367, DOI 10.1161/01.RES.62.2.367
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   KEANE WF, 1990, J AM SOC NEPHROL, V1, pS69
   Kitada M, 2011, DIABETES, V60, P634, DOI 10.2337/db10-0386
   Kurella M, 2005, J AM SOC NEPHROL, V16, P2134, DOI 10.1681/ASN.2005010106
   Li CX, 2011, CELL PHYSIOL BIOCHEM, V27, P691, DOI 10.1159/000330078
   Li L, 2014, BMC NEPHROL, V15, DOI 10.1186/1471-2369-15-122
   Liu X, 2008, J THROMB HAEMOST, V6, P184
   Maeda Y, 2010, AM J PHYSIOL-RENAL, V299, pF1328, DOI 10.1152/ajprenal.00337.2010
   Meng D, 2008, CARDIOVASC RES, V80, P299, DOI 10.1093/cvr/cvn173
   Miyata K, 2005, J AM SOC NEPHROL, V16, P2906, DOI 10.1681/ASN.2005040390
   Nam SM, 2009, DIABETES RES CLIN PR, V83, P176, DOI 10.1016/j.diabres.2008.10.007
   Nistala R, 2008, ANTIOXID REDOX SIGN, V10, P2047, DOI 10.1089/ars.2008.2034
   Nita M, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/3164734
   Oda M, 2002, MOL BIOL EVOL, V19, P640, DOI 10.1093/oxfordjournals.molbev.a004123
   Ohashi N, 2015, NEPHROLOGY, V20, P814, DOI 10.1111/nep.12504
   Panday A, 2015, CELL MOL IMMUNOL, V12, DOI 10.1038/cmi.2014.89
   Papadimitriou A, 2014, J NUTR BIOCHEM, V25, P773, DOI 10.1016/j.jnutbio.2014.03.010
   Pin-Lan L, 2007, CLIN CHEM LAB MED, V45, P1688, DOI 10.1515/CCLM.2007.344
   Prasad Sah Om Shankar, 2015, Nephrourol Mon, V7, pe27233, DOI 10.5812/numonthly.7(3)2015.27233
   Quigley JE, 2009, CLIN EXP PHARMACOL P, V36, P724, DOI 10.1111/j.1440-1681.2009.05139.x
   Ryu ES, 2013, AM J PHYSIOL-RENAL, V304, pF471, DOI 10.1152/ajprenal.00560.2012
   Sánchez-Lozada LG, 2008, AM J PHYSIOL-RENAL, V295, pF1134, DOI 10.1152/ajprenal.00104.2008
   Sánchez-Lozada LG, 2012, NEPHRON EXP NEPHROL, V121, pE71, DOI 10.1159/000345509
   Scheuer H, 2000, AM J PHYSIOL-RENAL, V278, pF63, DOI 10.1152/ajprenal.2000.278.1.F63
   Shankland SJ, 2006, KIDNEY INT, V69, P2131, DOI 10.1038/sj.ki.5000410
   Shastry S, 2007, KIDNEY INT, V71, P304, DOI 10.1038/sj.ki.5002031
   Shen KP, 2014, KAOHSIUNG J MED SCI, V30, P116, DOI 10.1016/j.kjms.2013.10.005
   Singh DK, 2011, NAT REV ENDOCRINOL, V7, P176, DOI 10.1038/nrendo.2010.212
   Stack A, 2015, Curr Med Res Opin, V31 Suppl 2, P21, DOI 10.1185/03007995.2015.1087984
   Susztak K, 2006, DIABETES, V55, P225, DOI 10.2337/diabetes.55.1.225
   Tojo A, 2007, EXPERT OPIN THER TAR, V11, P1011, DOI 10.1517/14728222.11.8.1011
   TOLINS JP, 1992, KIDNEY INT, V41, P1254, DOI 10.1038/ki.1992.187
   Toyonaga J, 2011, NEPHROL DIAL TRANSPL, V26, P2475, DOI 10.1093/ndt/gfq750
   Whaley-Connell A, 2008, HYPERTENSION, V51, P474, DOI 10.1161/HYPERTENSIONAHA.107.102467
   Whiteside C, 2009, EXP DIABETES RES, DOI 10.1155/2009/910783
   Wingler M, 2001, FREE RADICAL BIO MED, V31, P1456, DOI 10.1016/S0891-5849(01)00727-4
   Xia L, 2006, AM J PHYSIOL-RENAL, V290, pF345, DOI 10.1152/ajprenal.00119.2005
   Xu J, 2012, CELL STRESS CHAPERON, V17, P485, DOI 10.1007/s12192-012-0325-7
   Yang ZZ, 2003, KIDNEY INT, V63, P1012, DOI 10.1046/j.1523-1755.2003.00825.x
   Yi F, 2006, KIDNEY INT, V70, P88, DOI 10.1038/sj.ki.5001517
   Yi F, 2004, KIDNEY INT, V66, P1977, DOI 10.1111/j.1523-1755.2004.00968.x
   Yi F, 2008, AM J NEPHROL, V28, P254, DOI 10.1159/000110876
   Yi F, 2007, AM J NEPHROL, V27, P262, DOI 10.1159/000101471
   Yi F, 2009, HYPERTENSION, V53, P90, DOI 10.1161/HYPERTENSIONAHA.108.115675
   Yu LX, 2014, CELL SIGNAL, V26, P2979, DOI 10.1016/j.cellsig.2014.08.030
   Yu MA, 2010, J HYPERTENS, V28, P1234, DOI 10.1097/HJH.0b013e328337da1d
   Yung Lai Ming, 2006, Cardiovascular & Hematological Disorders - Drug Targets, V6, P1
   Zhang C, 2011, PFLUG ARCH EUR J PHY, V462, P455, DOI 10.1007/s00424-011-0981-y
   Zhang C, 2010, ANTIOXID REDOX SIGN, V13, P975, DOI 10.1089/ars.2010.3091
   Zhang C, 2010, BBA-MOL CELL RES, V1803, P482, DOI 10.1016/j.bbamcr.2009.12.006
   Zhang C, 2010, FREE RADICAL BIO MED, V48, P1109, DOI 10.1016/j.freeradbiomed.2010.01.029
   Zhang LY, 2012, INT J BIOCHEM CELL B, V44, P629, DOI 10.1016/j.biocel.2012.01.001
   Zhou LL, 2009, KIDNEY INT, V76, P1148, DOI 10.1038/ki.2009.322
NR 105
TC 38
Z9 45
U1 0
U2 9
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2016
VL 2016
AR 7813072
DI 10.1155/2016/7813072
PG 8
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA DU2ZK
UT WOS:000382080000001
PM 27597884
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Azab, SS
   Hosni, HE
   El Far, TA
   Ismail, NN
   El Bakdady, YK
   Mohamed, AF
AF Azab, Sherif Salah
   Hosni, Hossam El Din
   El Far, Taha A.
   Ismail, Nashaat Nabil
   El Bakdady, Yasser K.
   Mohamed, Ahmed F.
TI The Predictive Value of Arteriogenic Erectile Dysfunction for Coronary
   Artery Disease in Men
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE Erectile Dysfunction; Ischemic Heart Disease; Stress
   Electrocardiography; Metabolic Syndrome
ID RISK-FACTORS; ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; TESTOSTERONE;
   PREVALENCE; EVENTS; OLDER; AGE
AB Background: Erectile dysfunction (ED) is assumed to be connected with vascular disease caused by endothelial dysfunction, and characterized by the incapability of the smooth muscle cells lining the arterioles to relax, therefore, inhibit vasodilatation.
   Aim: To assess the predictive value of arteriogenic ED for coronary artery disease in men above the age of 40 years.
   Methods: 75 Patients reporting arteriogenic ED and 25 men with normal erectile function were enrolled in the study. Both patients and controls were subjected to the following investigations: lipid profile, fasting blood sugar, body mass index (BMI), waist circumference, penile duplex study, stress electrocardiography (ECG) test, International Index of Erectile Function (IIEF) Type 5 (Arabic version), and cardiovascular (CV) 10-year risk assessment using Framingham and Prospective Cardiovascular Munster (PROCAM) scoring systems.
   Outcomes: We compare between the study groups regarding the interpretation of exercise testing.
   Results: We observed significant increase in the mean value of age, systolic blood pressure, BMI, weight, height, and waist circumference in the cases; significant prevalence of obesity and overweight in the cases (P < .001); significant increase in the mean value of total cholesterol, triglycerides (TG), and low-density lipoprotein; and decrease in mean value of high-density lipoprotein in the cases (P < .001). Additionally, there was high incidence of positive stress ECG in the cases (25.3%) vs that in controls (12%), and significant difference between patients with positive stress ECG test and those with negative stress ECG test regarding their lipid profile, age, BMI, and waist circumference with higher values in positive stress ECG for total cholesterol, TG, and low-density lipoprotein, and lower value for high-density lipoprotein (P < .001). According to PROCAM and Framingham scoring systems 10-year risk assessment, there was a high significant difference between the cases and control groups with a higher score in cases than the control group with 30.7% of cases having >= 30% risk of developing coronary heart disease, and significant positive correlations between CV risk and BMI, and negative correlations with IIEF-5 cases (P < .001).
   Clinical Translation: Ischemic heart disease events were higher in men with documented arteriogenic ED than those without ED.
   Conclusions: All items of metabolic syndrome were investigated and analyzed and we evaluated our groups using both PROCAM and Framingham scoring system. An exercise ECG is suggested before starting treatment of vasculogenic ED at least in patients with CV risk factors. Copyright (C) 2018, International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.
C1 [Azab, Sherif Salah] October 6 Univ, Fac Med, Urol Dept, 7 el Gazal Wa el Nasseg,Lebanon Sq, Cairo 12411, Egypt.
   [Hosni, Hossam El Din] Cairo Univ, Fac Med, Androl Dept, Cairo, Egypt.
   [El Far, Taha A.] Cairo Univ, Fac Med, Cairo, Egypt.
   [Ismail, Nashaat Nabil] Beni Suef Univ, Fac Med, Androl Dept, Bani Suwayf, Egypt.
   [El Bakdady, Yasser K.] Cairo Univ, Fac Med, Cardiol Dept, Cairo, Egypt.
   [Mohamed, Ahmed F.] Cairo Univ, Fac Med, Androl & Sexually Transmitted Dis Dept, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); October 6 University (O6U); Egyptian
   Knowledge Bank (EKB); Cairo University; Egyptian Knowledge Bank (EKB);
   Cairo University; Egyptian Knowledge Bank (EKB); Beni Suef University;
   Egyptian Knowledge Bank (EKB); Cairo University; Egyptian Knowledge Bank
   (EKB); Cairo University
RP Azab, SS (corresponding author), October 6 Univ, Fac Med, Urol Dept, 7 el Gazal Wa el Nasseg,Lebanon Sq, Cairo 12411, Egypt.
EM ssazab@yahoo.com
RI Azab, Sherif/G-1712-2016
OI Azab, Sherif/0000-0003-1879-9343
CR Assmann G, 1996, AM J CARDIOL, V77, P1179, DOI 10.1016/S0002-9149(96)00159-2
   Bacon CG, 2003, ANN INTERN MED, V139, P161, DOI 10.7326/0003-4819-139-3-200308050-00005
   Batsis JA, 2008, AM J CARDIOL, V102, P930, DOI 10.1016/j.amjcard.2008.05.040
   Blanker MH, 2001, J AM GERIATR SOC, V49, P436, DOI 10.1046/j.1532-5415.2001.49088.x
   Camacho ME, 2005, INT J IMPOT RES, V17, pS52, DOI 10.1038/sj.ijir.3901429
   CELERMAJER DS, 1994, J AM COLL CARDIOL, V24, P1468, DOI 10.1016/0735-1097(94)90141-4
   DROLLER MJ, 1993, JAMA-J AM MED ASSOC, V270, P83
   Dzau V, 2005, J HYPERTENS, V23, pS9, DOI 10.1097/01.hjh.0000165623.72310.dd
   Feldman HA, 2000, PREV MED, V30, P328, DOI 10.1006/pmed.2000.0643
   Fung MM, 2004, J AM COLL CARDIOL, V43, P1405, DOI 10.1016/j.jacc.2003.11.041
   Gazzaruso C, 2004, CIRCULATION, V110, P22, DOI 10.1161/01.CIR.0000133278.81226.C9
   Genest J, 2009, CAN J CARDIOL, V25, P567, DOI 10.1016/S0828-282X(09)70715-9
   Giugliano F, 2004, J ENDOCRINOL INVEST, V27, P665, DOI 10.1007/BF03347500
   Hatzimouratidis K, 2010, EUR UROL, V57, P918, DOI 10.1016/j.eururo.2010.02.014
   Heidler S, 2007, J UROLOGY, V177, P651, DOI 10.1016/j.juro.2006.09.043
   Inman BA, 2009, MAYO CLIN PROC, V84, P108, DOI 10.4065/84.2.108
   Jackson G, 2008, J SEX MED, V5, P49
   Kirby M, 2005, INT J CLIN PRACT, V59, P225, DOI 10.1111/j.1742-1241.2005.00453.x
   Knoblovits P, 2010, J ANDROL, V31, P263, DOI 10.2164/jandrol.109.007757
   Koenig W, 2004, CIRCULATION, V109, P1349, DOI 10.1161/01.CIR.0000120707.98922.E3
   Kupelian V, 2006, J CLIN ENDOCR METAB, V91, P843, DOI 10.1210/jc.2005-1326
   Lahoz C, 2007, REV ESP CARDIOL, V60, P184, DOI 10.1157/13099465
   Lowenstein L, 2007, EUR J OBSTET GYN R B, V134, P208, DOI 10.1016/j.ejogrb.2007.02.011
   Meuleman EJH, 2002, INT J IMPOT RES, V14, pS22, DOI 10.1038/sj/ijir/3900793
   Montorsi F, 2003, EUR UROL, V44, P360, DOI 10.1016/S0302-2838(03)00305-1
   Montorsi P, 2006, EUR HEART J, V27, P2632, DOI 10.1093/eurheartj/ehl142
   Mulhall J, 2009, J SEX MED, V6, P820, DOI 10.1111/j.1743-6109.2008.01087.x
   Ponholzer A, 2010, INT J IMPOT RES, V22, P25, DOI 10.1038/ijir.2009.40
   Rosen RC, 1997, UROLOGY, V49, P822, DOI 10.1016/S0090-4295(97)00238-0
   Rosen RC, 2005, LANCET, V366, P183, DOI 10.1016/S0140-6736(05)66885-7
   SHABSIGH R, 1991, UROLOGY, V38, P227, DOI 10.1016/S0090-4295(91)80350-G
   Shamloul R, 2004, INT J IMPOT RES, V16, P235, DOI 10.1038/sj.ijir.3901148
   Solomon H, 2003, AM J CARDIOL, V91, P230, DOI 10.1016/S0002-9149(02)03113-2
NR 33
TC 6
Z9 7
U1 0
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD JUN
PY 2018
VL 15
IS 6
BP 880
EP 887
DI 10.1016/j.jsxm.2018.04.639
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA GH4ZA
UT WOS:000433423700011
PM 29759909
DA 2025-06-11
ER

PT J
AU Poulios, E
   Koukounari, S
   Psara, E
   Vasios, GK
   Sakarikou, C
   Giaginis, C
AF Poulios, Efthymios
   Koukounari, Stergia
   Psara, Evmorfia
   Vasios, Georgios K.
   Sakarikou, Christina
   Giaginis, Constantinos
TI Anti-obesity Properties of Phytochemicals: Highlighting their Molecular
   Mechanisms against Obesity
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Phytochemicals; obesity; metabolism; metabolic diseases; inflammation;
   oxidative stress; molecular mechanisms
ID HIGH-FAT-DIET; CONJUGATED LINOLEIC-ACID; WHITE ADIPOSE-TISSUE;
   DOSE-RESPONSE METAANALYSIS; INDUCED INSULIN-RESISTANCE; DOUBLE-BLIND;
   METABOLIC SYNDROME; HEPATIC STEATOSIS; REDUCES OBESITY; BERBERINE
   SUPPLEMENTATION
AB Obesity is a complex, chronic and inflammatory disease that affects more than one-third of the world's population, leading to a higher incidence of diabetes, dyslipidemia, metabolic syndrome, cardiovascular diseases, and some types of cancer. Several phytochemicals are used as flavoring and aromatic compounds, also exerting many benefits for public health. This study aims to summarize and scrutinize the beneficial effects of the most important phytochemicals against obesity. Systematic research of the current international literature was carried out in the most accurate scientific databases, e.g., Pubmed, Scopus, Web of Science and Google Scholar, using a set of critical and representative keywords, such as phytochemicals, obesity, metabolism, metabolic syndrome, etc. Several studies unraveled the potential positive effects of phytochemicals such as berberine, carvacrol, curcumin, quercetin, resveratrol, thymol, etc., against obesity and metabolic disorders. Mechanisms of action include inhibition of adipocyte differentiation, browning of the white adipose tissue, inhibition of enzymes such as lipase and amylase, suppression of inflammation, improvement of the gut microbiota, and downregulation of obesity-inducing genes. In conclusion, multiple bioactive compounds-phytochemicals exert many beneficial effects against obesity. Future molecular and clinical studies must be performed to unravel the multiple molecular mechanisms and anti-obesity activities of these naturally occurring bioactive compounds.
C1 [Poulios, Efthymios; Koukounari, Stergia; Psara, Evmorfia; Vasios, Georgios K.; Sakarikou, Christina; Giaginis, Constantinos] Univ Aegean, Sch Environm, Dept Food Sci & Nutr, Myrina, Lemnos, Greece.
RP Giaginis, C (corresponding author), Univ Aegean, Sch Environm, Dept Food Sci & Nutr, Myrina, Lemnos, Greece.
EM epoulios@aegean.gr
RI Giaginis, Constantinos/JMQ-9552-2023; Poulios, Efthymios/HSH-0842-2023
FU Declared none.
FX Declared none.
CR Aba Patrick E., 2023, Journal of Basic and Clinical Physiology and Pharmacology, V34, P419, DOI 10.1515/jbcpp-2021-0257
   Al-Saud NBS, 2020, SAUDI J BIOL SCI, V27, P689, DOI 10.1016/j.sjbs.2019.11.037
   Alsharif FJ, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020680
   Ariamoghaddam AR, 2018, MAT SCI ENG C-MATER, V92, P161, DOI 10.1016/j.msec.2018.06.030
   Arzola-Paniagua MA, 2016, OBESITY, V24, P1454, DOI 10.1002/oby.21523
   Asbaghi O, 2020, CLIN NUTR ESPEN, V38, P43, DOI 10.1016/j.clnesp.2020.04.010
   Ashigai H, 2016, BIOL PHARM BULL, V39, P699, DOI 10.1248/bpb.b15-00662
   Atazadegan MA, 2021, ADV EXP MED BIOL, V1328, P37, DOI 10.1007/978-3-030-73234-9_4
   Ayaz M, 2019, CHEM-BIOL INTERACT, V308, P294, DOI 10.1016/j.cbi.2019.05.050
   Barakat B, 2021, ARCH BIOCHEM BIOPHYS, V708, DOI 10.1016/j.abb.2021.108951
   Barber TM, 2022, NUTRIENTS, V14, DOI 10.3390/nu14142870
   Basak S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12071913
   Baskaran P, 2016, BRIT J PHARMACOL, V173, P2369, DOI 10.1111/bph.13514
   Bian YF, 2022, J NUTR BIOCHEM, V99, DOI 10.1016/j.jnutbio.2021.108840
   Bouchard C, 2021, OBESITY, V29, P802, DOI 10.1002/oby.23116
   Bracale R, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0098244
   Bradford PG, 2013, BIOFACTORS, V39, P78, DOI 10.1002/biof.1074
   Byun JK, 2014, IMMUNOL LETT, V157, P51, DOI 10.1016/j.imlet.2013.11.006
   Carpéné C, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8030074
   Castro-Rodríguez DC, 2021, EXP GERONTOL, V154, DOI 10.1016/j.exger.2021.111511
   Chang H, 2020, NUTR METAB CARDIOVAS, V30, P1777, DOI 10.1016/j.numecd.2020.05.029
   Chang YH, 2022, EUR J MED CHEM, V237, DOI 10.1016/j.ejmech.2022.114405
   Chen YK, 2011, J AGR FOOD CHEM, V59, P11862, DOI 10.1021/jf2029016
   Chen YS, 2021, EMBO REP, V22, DOI 10.15252/embr.202052146
   Chiurazzi M, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21239035
   Cho S, 2012, J NUTR BIOCHEM, V23, P192, DOI 10.1016/j.jnutbio.2010.11.016
   Conceiçao-Furber E, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.868037
   Costa MC, 2020, J NUTR BIOCHEM, V76, DOI 10.1016/j.jnutbio.2019.108303
   Cote B, 2022, MOLECULES, V27, DOI 10.3390/molecules27030781
   D'Esposito V, 2021, INT J OBESITY, V45, P1811, DOI 10.1038/s41366-021-00850-1
   Dangol M, 2017, J CONTROL RELEASE, V265, P41, DOI 10.1016/j.jconrel.2017.03.400
   de Melo CL, 2010, CHEM-BIOL INTERACT, V185, P59, DOI 10.1016/j.cbi.2010.02.028
   Deepika, 2022, MOLECULES, V27, DOI 10.3390/molecules27082498
   den Hartigh LJ, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020370
   Dincer Y, 2021, NUTRITION, V84, DOI 10.1016/j.nut.2020.111119
   Ding LL, 2016, TOXICOL APPL PHARM, V304, P99, DOI 10.1016/j.taap.2016.05.011
   Djeziri FZ, 2018, BIOCHIMIE, V152, P110, DOI 10.1016/j.biochi.2018.06.025
   Dong J, 2014, J LIPID RES, V55, P363, DOI 10.1194/jlr.M038786
   Dumont J, 2018, CLIN NUTR, V37, P1683, DOI 10.1016/j.clnu.2017.07.012
   Fattori V, 2016, MOLECULES, V21, DOI 10.3390/molecules21070844
   Feng Y, 2010, BRIT J PHARMACOL, V161, P113, DOI 10.1111/j.1476-5381.2010.00826.x
   Ferguson Bradley S, 2016, Biochem Biophys Rep, V5, P16, DOI 10.1016/j.bbrep.2015.11.014
   Fraiz GM, 2021, EUR J NUTR, V60, P2961, DOI 10.1007/s00394-021-02623-y
   Ganjali S, 2014, SCI WORLD J, DOI 10.1155/2014/898361
   Ghadieh HE, 2015, NUTR METAB, V12, DOI 10.1186/s12986-015-0014-5
   Gómez-Zorita S, 2013, NUTRITION, V29, P1374, DOI 10.1016/j.nut.2013.04.014
   González-Garibay AS, 2020, J MED FOOD, V23, P297, DOI 10.1089/jmf.2019.0154
   Gregory J, 2021, BIOMOLECULES, V11, DOI 10.3390/biom11040543
   Griffin LE, 2021, J NUTR BIOCHEM, V87, DOI 10.1016/j.jnutbio.2020.108521
   Gu QY, 2022, J NUTR BIOCHEM, V108, DOI 10.1016/j.jnutbio.2022.109085
   Guo X, 2018, FOOD FUNCT, V9, P6049, DOI 10.1039/c8fo01026a
   Habtemariam S, 2020, PHARMACOL RES, V155, DOI 10.1016/j.phrs.2020.104722
   Habtemariam S, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19010004
   Hamauzu Y, 2019, FOOD CHEM, V293, P127, DOI 10.1016/j.foodchem.2019.04.092
   Han YB, 2020, INT IMMUNOPHARMACOL, V86, DOI 10.1016/j.intimp.2020.106741
   Han ZQ, 2021, FOOD FUNCT, V12, P6558, DOI [10.1039/d1fo00671a, 10.1039/D1FO00671A]
   Hao JY, 2022, FOODS, V11, DOI 10.3390/foods11081170
   Haque MR, 2014, TOXICOL MECH METHOD, V24, P116, DOI 10.3109/15376516.2013.861888
   He XY, 2021, J SCI FOOD AGR, V101, P631, DOI 10.1002/jsfa.10675
   He YF, 2022, J CLIN ENDOCR METAB, V107, P2606, DOI 10.1210/clinem/dgac367
   Hellmann PH, 2022, DIABETES OBES METAB, V24, P2192, DOI 10.1111/dom.14804
   Hillsley A, 2022, NUTRIENTS, V14, DOI 10.3390/nu14071424
   Hirotani Y, 2017, BIOL PHARM BULL, V40, P1581, DOI 10.1248/bpb.b17-00247
   Hofer SJ, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.717343
   Hosseini A, 2021, PHYTOTHER RES, V35, P5352, DOI 10.1002/ptr.7144
   Hruby A, 2015, PHARMACOECONOMICS, V33, P673, DOI 10.1007/s40273-014-0243-x
   Hsu MH, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21103428
   Hu DH, 2021, NUTR CANCER, V73, P652, DOI 10.1080/01635581.2020.1767166
   Huang JB, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700696
   Huang YJ, 2019, AGING-US, V11, P2217, DOI 10.18632/aging.101910
   Nguyen HN, 2018, ATHEROSCLEROSIS, V275, P333, DOI 10.1016/j.atherosclerosis.2018.06.882
   Ibrahim KS, 2021, J BIOSCIENCES, V46, DOI 10.1007/s12038-020-00133-3
   Ikeda I, 2003, J AGR FOOD CHEM, V51, P7303, DOI 10.1021/jf034728l
   Ikeda I, 2010, J AGR FOOD CHEM, V58, P8591, DOI 10.1021/jf1015285
   Ilyas Z, 2020, BIOMED PHARMACOTHER, V127, DOI 10.1016/j.biopha.2020.110137
   Islam T, 2021, MOL NUTR FOOD RES, V65, DOI 10.1002/mnfr.202100274
   Jebeile H, 2022, LANCET DIABETES ENDO, V10, P351, DOI 10.1016/S2213-8587(22)00047-X
   Jiang H, 2020, J CLIN BIOCHEM NUTR, V67, P74, DOI 10.3164/jcbn.20-47
   Jit BP, 2022, PHYTOMEDICINE, V106, DOI 10.1016/j.phymed.2022.154188
   Juarez-Fernandez M, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10122001
   Kamyab R, 2021, ADV PHARM BULL, V11, P601, DOI 10.34172/apb.2021.090
   Kang C, 2017, MBIO, V8, DOI [10.1128/mBio.00470-17, 10.1128/mbio.00470-17, 10.1128/mBio.00900-17]
   Kang JH, 2010, OBESITY, V18, P780, DOI 10.1038/oby.2009.301
   Karandish M, 2022, DIABETOL METAB SYNDR, V14, DOI 10.1186/s13098-022-00792-2
   Khan FA, 2016, J FOOD DRUG ANAL, V24, P695, DOI 10.1016/j.jfda.2016.05.003
   Khare P, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01244
   Kim HY, 2015, MOLECULES, V20, P3107, DOI 10.3390/molecules20023107
   Kim JH, 2012, FOOD FUNCT, V3, P1280, DOI 10.1039/c2fo30103b
   Kim OY, 2019, PHARMACOL RES, V148, DOI 10.1016/j.phrs.2019.104411
   Kim Y, 2015, J AGR FOOD CHEM, V63, P5212, DOI 10.1021/acs.jafc.5b00840
   Kobori M, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-27105-w
   Koboziev I, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10101368
   Kotha RR, 2019, MOLECULES, V24, DOI 10.3390/molecules24162930
   Kumar R, 2020, CURR MOL PHARMACOL, V13, P7, DOI 10.2174/1874467212666190716145210
   Kumar S, 2021, CURR DIABETES REV, V17, P437, DOI 10.2174/1573399816666201103143225
   Kunkel SD, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039332
   Lee D, 2022, NUTRIENTS, V14, DOI 10.3390/nu14102164
   Leung FW, 2014, PROG DRUG RES, V68, P171, DOI 10.1007/978-3-0348-0828-6_7
   Li HB, 2019, PHARMACOL RES, V147, DOI 10.1016/j.phrs.2019.104393
   Li R, 2020, FOOD FUNCT, V11, P7356, DOI [10.1039/d0fo01467b, 10.1039/D0FO01467B]
   Li S, 2021, FOOD RES INT, V143, DOI 10.1016/j.foodres.2021.110270
   Li WQ, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.697483
   Liang CW, 2023, NUTR REV, V81, P397, DOI 10.1093/nutrit/nuac060
   Liao CC, 2013, J AGR FOOD CHEM, V61, P11082, DOI 10.1021/jf4026647
   Vizin RCL, 2018, J APPL PHYSIOL, V124, P672, DOI 10.1152/japplphysiol.00770.2017
   Lim XY, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.611408
   Liu E, 2021, PLANT FOOD HUM NUTR, V76, P377, DOI 10.1007/s11130-020-00852-w
   Liu H, 2022, FREE RADICAL BIO MED, V181, P105, DOI 10.1016/j.freeradbiomed.2022.02.002
   Liu LN, 2020, FOOD FUNCT, V11, P9729, DOI [10.1039/d0fo02112a, 10.1039/D0FO02112A]
   Lu MW, 2017, FOOD FUNCT, V8, P1803, DOI 10.1039/c7fo00173h
   Ma PY, 2022, PHARMACOL RES, V178, DOI 10.1016/j.phrs.2022.106175
   Madry E, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061811
   Maithilikarpagaselvi Nachimuthu, 2016, J Complement Integr Med, V13, P137, DOI 10.1515/jcim-2015-0070
   Martínez-Morúa A, 2013, J ASIAN NAT PROD RES, V15, P905, DOI 10.1080/10286020.2013.802687
   Meeran MFN, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00380
   Mokgalaboni K, 2021, FOOD FUNCT, V12, P12235, DOI [10.1039/d1fo02696h, 10.1039/D1FO02696H]
   Mousavi SM, 2019, OBES REV, V20, P487, DOI 10.1111/obr.12775
   Naidu PB, 2016, MOL CELL ENDOCRINOL, V419, P139, DOI 10.1016/j.mce.2015.10.007
   Namazi N, 2019, CRIT REV FOOD SCI, V59, P2720, DOI 10.1080/10408398.2018.1466107
   Naoi M, 2022, J NEURAL TRANSM, V129, P737, DOI 10.1007/s00702-021-02427-8
   Neilson AP, 2017, NUTRITION IN THE PREVENTION AND TREATMENT OF DISEASE, 4TH EDITION, P301, DOI 10.1016/B978-0-12-802928-2.00015-1
   Nettore IC, 2019, J NUTR BIOCHEM, V69, P151, DOI 10.1016/j.jnutbio.2019.03.019
   Nicoletti CF, 2019, NUTR HOSP, V36, P315, DOI 10.20960/nh.2216
   Noh JW, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10071739
   Nosrati-Oskouie M, 2021, PHYTOTHER RES, V35, P4748, DOI 10.1002/ptr.7105
   Nurcahyanti ADR, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.891339
   O'Reilly ME, 2020, MOL NUTR FOOD RES, V64, DOI 10.1002/mnfr.201900599
   Obeid MA, 2023, J LIPOSOME RES, V33, P53, DOI 10.1080/08982104.2022.2086567
   Obri A, 2020, BIOCHEM PHARMACOL, V177, DOI 10.1016/j.bcp.2020.113973
   Ogawa K, 2016, J AGR FOOD CHEM, V64, P204, DOI 10.1021/acs.jafc.5b05088
   Oh Seung-Lyul, 2017, J Exerc Nutrition Biochem, V21, P11, DOI 10.20463/jenb.2017.0028
   Ohara T, 2016, NUTR J, V15, DOI 10.1186/s12937-016-0123-7
   Ohara T, 2015, PHYTOTHER RES, V29, P310, DOI 10.1002/ptr.5258
   Palou A, 2013, NUTR HOSP, V28, P144, DOI 10.3305/nh.2013.28.sup5.6930
   Pan SF, 2022, ANIM BIOSCI, V35, P763, DOI 10.5713/ab.21.0371
   Park UH, 2022, BIOCHEM BIOPH RES CO, V617, P48, DOI 10.1016/j.bbrc.2022.05.098
   Pei Y, 2021, J NUTR BIOCHEM, V88, DOI 10.1016/j.jnutbio.2020.108532
   Poulios E, 2021, EXPERT REV ANTI-INFE, V19, P519, DOI 10.1080/14787210.2021.1828061
   Poulios E, 2019, CURR PHARM BIOTECHNO, V20, P845, DOI 10.2174/1389201020666190722130440
   Pourhabibi-Zarandi F, 2022, PHYTOTHER RES, V36, P1797, DOI 10.1002/ptr.7422
   Rao VS, 2011, J MED FOOD, V14, P1375, DOI 10.1089/jmf.2010.0267
   Rebello CJ, 2022, OBESITY, V30, P874, DOI 10.1002/oby.23384
   Reja D, 2022, TRANSL GASTROENT HEP, V7, DOI 10.21037/tgh.2020.03.09
   Reyad-ul Ferdous M, 2023, J BIOMOL STRUCT DYN, V41, P1704, DOI 10.1080/07391102.2021.2024255
   Romero-Juárez PA, 2023, NUTR NEUROSCI, V26, P25, DOI 10.1080/1028415X.2021.2012629
   Safari Zahra, 2021, Adv Exp Med Biol, V1291, P121, DOI 10.1007/978-3-030-56153-6_7
   Sakakibara T, 2019, J AGR FOOD CHEM, V67, P7128, DOI 10.1021/acs.jafc.9b02265
   Sakuma S, 2017, TOXICOL APPL PHARM, V329, P158, DOI 10.1016/j.taap.2017.05.036
   Salehi B, 2018, PHYTOTHER RES, V32, P1688, DOI 10.1002/ptr.6109
   Sampath C, 2017, BIOMED PHARMACOTHER, V87, P73, DOI 10.1016/j.biopha.2016.12.082
   Sanders OD, 2021, J OBES METAB SYNDR, V30, P4
   Sangouni AA, 2022, NUTR J, V21, DOI 10.1186/s12937-022-00816-7
   Santhiravel S, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23158124
   Saqib U, 2021, CELL MOL BIOL, V67, P177, DOI 10.14715/cmb/2021.67.1.27
   Saravanan G, 2014, J SCI FOOD AGR, V94, P2972, DOI 10.1002/jsfa.6642
   Sathyanarayana AR, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23074052
   Segovia SA, 2015, J NUTR BIOCHEM, V26, P1448, DOI 10.1016/j.jnutbio.2015.07.013
   Aksoy IS, 2022, MOLECULES, V27, DOI 10.3390/molecules27041243
   Seo MJ, 2015, J NUTR BIOCHEM, V26, P1308, DOI 10.1016/j.jnutbio.2015.06.005
   Shabani M, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-60185-1
   Shabbir U, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010206
   Shahmirzadi FE, 2019, ARCH IRAN MED, V22, P255
   Shanmugham V, 2022, FOOD TECHNOL BIOTECH, V60, P202, DOI 10.17113/ftb.60.02.22.7376
   Shao WT, 2021, ENVIRON POLLUT, V272, DOI 10.1016/j.envpol.2020.115974
   Sharifi-Rad M, 2018, PHYTOTHER RES, V32, P1675, DOI 10.1002/ptr.6103
   Shen L, 2017, FOOD NUTR RES, V61, DOI 10.1080/16546628.2017.1361780
   Shen W, 2017, FRONT MICROBIOL, V8, P1, DOI 10.3389/fmicb.2017.00272
   Sheng LL, 2018, FASEB J, V32, P6371, DOI 10.1096/fj.201800370R
   Shi M, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11061158
   Shi XD, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11071338
   Shin SH, 2014, J AGR FOOD CHEM, V62, P4306, DOI 10.1021/jf405088f
   Singh AP, 2019, MED RES REV, V39, P1851, DOI 10.1002/med.21565
   Singh S, 2021, EUR J MED CHEM, V226, DOI 10.1016/j.ejmech.2021.113839
   Song XR, 2022, FOOD RES INT, V153, DOI 10.1016/j.foodres.2022.110971
   Spalletta S, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0206894
   Sun RB, 2017, MOL PHARMACOL, V91, P110, DOI 10.1124/mol.116.106617
   Sun XW, 2022, J NUTR BIOCHEM, V109, DOI 10.1016/j.jnutbio.2022.109094
   Sun Y, 2022, VET MED SCI, V8, P2538, DOI 10.1002/vms3.921
   Sung HY, 2010, NUTR RES, V30, P831, DOI 10.1016/j.nutres.2010.10.001
   Suzuki T, 2016, MOLECULES, V21, DOI 10.3390/molecules21101305
   Szkudelska K, 2010, EUR J PHARMACOL, V635, P1, DOI 10.1016/j.ejphar.2010.02.054
   Tan YQ, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10081251
   Tang SG, 2022, J OLEO SCI, V71, P289, DOI 10.5650/jos.ess21258
   Tian LL, 2017, CELL DEATH DIS, V8, DOI 10.1038/cddis.2016.455
   Torres-Villarreal D, 2019, J PHYSIOL BIOCHEM, V75, P83, DOI 10.1007/s13105-018-0659-4
   Vafaeipour Z, 2022, J INTEGR MED-JIM, V20, P193, DOI 10.1016/j.joim.2022.02.008
   Valentine C, 2019, J CLIN BIOCHEM NUTR, V65, P91, DOI 10.3164/jcbn.19-7
   Wallis N, 2020, GENES-BASEL, V11, DOI 10.3390/genes11111378
   Wang M, 2022, COMMUN BIOL, V5, DOI 10.1038/s42003-022-03776-0
   Wang P, 2020, FREE RADICAL BIO MED, V156, P83, DOI 10.1016/j.freeradbiomed.2020.04.013
   Wang P, 2020, INT J OBESITY, V44, P213, DOI 10.1038/s41366-019-0332-1
   Wang S, 2014, J NUTR BIOCHEM, V25, P1, DOI 10.1016/j.jnutbio.2013.09.001
   Wang TQ, 2020, BIOMED RES INT, V2020, DOI 10.1155/2020/4532482
   Wang YF, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.1022794
   Wang YW, 2020, FOOD NUTR RES, V64, DOI 10.29219/fnr.v64.3525
   Wang ZY, 2019, FOOD SCI NUTR, V7, P579, DOI 10.1002/fsn3.868
   Wen X, 2022, SIGNAL TRANSDUCT TAR, V7, DOI 10.1038/s41392-022-01149-x
   Wlodarczyk M, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20051146
   Wu D, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.908868
   Wu LY, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102307
   Wu LF, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms15904
   Wu YY, 2016, MOL MED REP, V14, P2725, DOI 10.3892/mmr.2016.5545
   Xiong HJ, 2019, DRUG DES DEV THER, V13, P3855, DOI 10.2147/DDDT.S227499
   Xiong P, 2020, COMPLEMENT THER CLIN, V39, DOI 10.1016/j.ctcp.2020.101113
   Xu XM, 2021, BIOMED PHARMACOTHER, V133, DOI 10.1016/j.biopha.2020.110984
   Xu Y, 2015, FOOD FUNCT, V6, P297, DOI 10.1039/c4fo00970c
   Yang L, 2012, PHYTOTHER RES, V26, P438, DOI 10.1002/ptr.3604
   Yang Z, 2019, PHYTOTHER RES, V33, P1019, DOI 10.1002/ptr.6295
   Ye Y, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.653887
   Yin LJ, 2021, CLIN CHIM ACTA, V515, P80, DOI 10.1016/j.cca.2021.01.001
   Yisimayili Z, 2022, FOOD CHEM, V395, DOI 10.1016/j.foodchem.2022.133600
   Zang YQ, 2015, FOOD FUNCT, V6, P834, DOI [10.1039/c4fo00844h, 10.1039/C4FO00844H]
   Zhang LC, 2021, FRONT CELL INFECT MI, V10, DOI 10.3389/fcimb.2020.588517
   Zhang X, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0040320, 10.1371/journal.pone.0042529]
   Zhao DD, 2021, ROY SOC OPEN SCI, V8, DOI 10.1098/rsos.200974
   Zhao L, 2017, EXP THER MED, V14, P5942, DOI 10.3892/etm.2017.5331
   Zhao XY, 2021, MEDICINA-LITHUANIA, V57, DOI 10.3390/medicina57030266
   Zhao YS, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/1459497
   Zheng J, 2017, BIOSCIENCE REP, V37, DOI 10.1042/BSR20170286
   Zhu L, 2015, MOL MED REP, V12, P1151, DOI 10.3892/mmr.2015.3450
   Zhu MZ, 2021, FOOD FUNCT, V12, P4105, DOI [10.1039/d0fo01768j, 10.1039/D0FO01768J]
   Zhuang P, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201800448
   Zhuang TX, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.655563
   Zingg JM, 2017, BIOFACTORS, V43, P42, DOI 10.1002/biof.1307
   Zsiborás C, 2018, CRIT REV FOOD SCI, V58, P1419, DOI 10.1080/10408398.2016.1262324
   Zu YJ, 2021, J CONTROL RELEASE, V333, P339, DOI 10.1016/j.jconrel.2021.03.022
NR 226
TC 7
Z9 7
U1 5
U2 75
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2024
VL 31
IS 1
BP 25
EP 61
DI 10.2174/0929867330666230517124033
PG 37
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA R8WL9
UT WOS:001067103100004
PM 37198988
DA 2025-06-11
ER

PT J
AU Lemos, GD
   Torrinhas, RS
   Waitzberg, DL
AF Lemos, Gabriela de Oliveira
   Torrinhas, Raquel Susana
   Waitzberg, Dan Linetzky
TI Nutrients, Physical Activity, and Mitochondrial Dysfunction in the
   Setting of Metabolic Syndrome
SO NUTRIENTS
LA English
DT Review
DE metabolic syndrome; mitochondrial function; sphingolipids; ceramides;
   diet; exercise
ID MEDIUM-CHAIN TRIGLYCERIDES; FATTY LIVER-DISEASE; SWEETENED BEVERAGE
   CONSUMPTION; SKELETAL-MUSCLE CELLS; VIRGIN OLIVE OIL;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; COCONUT OIL; DIABETES-MELLITUS;
   HEPATIC STEATOSIS
AB Metabolic syndrome (MetS) is a cluster of metabolic risk factors for diabetes, coronary heart disease, non-alcoholic fatty liver disease, and some tumors. It includes insulin resistance, visceral adiposity, hypertension, and dyslipidemia. MetS is primarily linked to lipotoxicity, with ectopic fat deposition from fat storage exhaustion, more than obesity per se. Excessive intake of long-chain saturated fatty acid and sugar closely relates to lipotoxicity and MetS through several pathways, including toll-like receptor 4 activation, peroxisome proliferator-activated receptor-gamma regulation (PPAR gamma), sphingolipids remodeling, and protein kinase C activation. These mechanisms prompt mitochondrial dysfunction, which plays a key role in disrupting the metabolism of fatty acids and proteins and in developing insulin resistance. By contrast, the intake of monounsaturated, polyunsaturated, and medium-chain saturated (low-dose) fatty acids, as well as plant-based proteins and whey protein, favors an improvement in sphingolipid composition and metabolic profile. Along with dietary modification, regular exercises including aerobic, resistance, or combined training can target sphingolipid metabolism and improve mitochondrial function and MetS components. This review aimed to summarize the main dietary and biochemical aspects related to the physiopathology of MetS and its implications for mitochondrial machinery while discussing the potential role of diet and exercise in counteracting this complex clustering of metabolic dysfunctions.
C1 [Lemos, Gabriela de Oliveira; Torrinhas, Raquel Susana; Waitzberg, Dan Linetzky] Univ Sao Paulo, Dept Gastroenterol, Lab Nutr & Metab Surg Digest Tract LIM 35, Sch Med FMUSP, Av Dr Arnaldo 455,2 andar,sala 2208, BR-01246903 Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo
RP Lemos, GD (corresponding author), Univ Sao Paulo, Dept Gastroenterol, Lab Nutr & Metab Surg Digest Tract LIM 35, Sch Med FMUSP, Av Dr Arnaldo 455,2 andar,sala 2208, BR-01246903 Sao Paulo, SP, Brazil.
EM dra.golemos@gmail.com
RI Torrinhas, Raquel/AAH-4722-2019
OI De Oliveira Lemos, Gabriela/0000-0003-0943-1387; Waitzberg,
   Dan/0000-0002-9196-9372
CR Adams SH, 2009, J NUTR, V139, P1073, DOI 10.3945/jn.108.103754
   Adeyemi WJ, 2020, BIOMED PHARMACOTHER, V126, DOI 10.1016/j.biopha.2020.110110
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Yousefabadi HA, 2021, BIOL RES NURS, V23, P280, DOI 10.1177/1099800420958068
   Amirani E, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-01384-7
   Anderssen SA, 2007, SCAND J MED SCI SPOR, V17, P687, DOI 10.1111/j.1600-0838.2006.00631.x
   Ansarimoghaddam A, 2018, DIABETES METAB SYND, V12, P195, DOI 10.1016/j.dsx.2017.11.004
   Badely M, 2019, DIABETES METAB SYND, V13, P3121, DOI 10.1016/j.dsx.2019.11.001
   Barbier O, 2002, ARTERIOSCL THROM VAS, V22, P717, DOI 10.1161/01.ATV.0000015598.86369.04
   Barrès R, 2009, CELL METAB, V10, P189, DOI 10.1016/j.cmet.2009.07.011
   Boon J, 2013, DIABETES, V62, P401, DOI 10.2337/db12-0686
   Broskey NT, 2018, METABOLISM, V82, P118, DOI 10.1016/j.metabol.2017.12.012
   Butcher LR, 2008, MED SCI SPORT EXER, V40, P1263, DOI 10.1249/MSS.0b013e31816c091d
   Calder PC, 2002, P NUTR SOC, V61, P345, DOI 10.1079/PNS2002166
   Camacho-Muñoz D, 2022, BIOCHEM PHARMACOL, V204, DOI 10.1016/j.bcp.2022.115211
   Carobbio S, 2011, CURR OPIN CLIN NUTR, V14, P520, DOI 10.1097/MCO.0b013e32834ad966
   Chalvon-Demersay T, 2017, J NUTR, V147, P281, DOI 10.3945/jn.116.239574
   Chan AML, 2021, NUTRIENTS, V13, DOI 10.3390/nu13082497
   Chaurasia B, 2021, ANNU REV PHYSIOL, V83, P303, DOI 10.1146/annurev-physiol-031620-093815
   Cheng SL, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0138889
   Chiavaroli L, 2015, J AM HEART ASSOC, V4, DOI 10.1161/JAHA.114.001700
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   COLBERG SR, 1995, J CLIN INVEST, V95, P1846, DOI 10.1172/JCI117864
   Coll T, 2008, J BIOL CHEM, V283, P11107, DOI 10.1074/jbc.M708700200
   Chamma CMD, 2017, FOOD FUNCT, V8, P778, DOI [10.1039/c6fo01663d, 10.1039/C6FO01663D]
   Valadares LTD, 2022, BMC PUBLIC HEALTH, V22, DOI 10.1186/s12889-022-12753-5
   DeLany JP, 2000, AM J CLIN NUTR, V72, P905
   Dong YQ, 2017, ACTA PHARMACOL SIN, V38, P1601, DOI 10.1038/aps.2017.127
   Okada LSDR, 2018, CLIN NUTR, V37, P1474, DOI 10.1016/j.clnu.2017.08.031
   Dubé JJ, 2011, DIABETOLOGIA, V54, P1147, DOI 10.1007/s00125-011-2065-0
   Fretts AM, 2021, J LIPID RES, V62, DOI 10.1016/j.jlr.2021.100119
   Fu CE, 2023, ALIMENT PHARM THER, V57, P979, DOI 10.1111/apt.17397
   Ghadir MR, 2010, HEPAT MON, V10, P285
   Golpour P, 2020, DIABETES RES CLIN PR, V162, DOI 10.1016/j.diabres.2020.108120
   Gong LL, 2020, DIS MARKERS, V2020, DOI 10.1155/2020/8842320
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Haus JM, 2009, DIABETES, V58, P337, DOI 10.2337/db08-1228
   Henique C, 2010, J BIOL CHEM, V285, P36818, DOI 10.1074/jbc.M110.170431
   Heo JW, 2021, FASEB J, V35, DOI 10.1096/fj.202002394R
   Heshmati J, 2019, PHARMACOL RES, V149, DOI 10.1016/j.phrs.2019.104462
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Holland WL, 2008, ENDOCR REV, V29, P381, DOI 10.1210/er.2007-0025
   HOPPEL CL, 1980, AM J PHYSIOL, V238, pE409, DOI 10.1152/ajpendo.1980.238.5.E409
   Hosseinpour-Niazi S, 2020, DIABETES RES CLIN PR, V161, DOI 10.1016/j.diabres.2020.108039
   Houttu V, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.1032164
   International Diabetes Federation, 2006, IDF CONS WORLDW DEF
   Jaeschke A, 2007, MOL CELL, V27, P498, DOI 10.1016/j.molcel.2007.07.008
   Jaiswal N, 2015, APOPTOSIS, V20, P930, DOI 10.1007/s10495-015-1128-y
   Jang H, 2020, CLIN NUTR, V39, P765, DOI 10.1016/j.clnu.2019.03.032
   Jia GH, 2014, PROG MOL BIOL TRANSL, V127, P229, DOI 10.1016/B978-0-12-394625-6.00009-X
   Pirola CJ, 2013, GUT, V62, P1356, DOI 10.1136/gutjnl-2012-302962
   Joseph MS, 2019, DIABET METAB SYND OB, V12, P2395, DOI 10.2147/DMSO.S211776
   Julibert A, 2019, NUTR METAB CARDIOVAS, V29, P887, DOI 10.1016/j.numecd.2019.05.055
   Kamaura M, 2010, CIRC J, V74, P2434, DOI 10.1253/circj.CJ-10-0150
   Kasumov T, 2015, OBESITY, V23, P1414, DOI 10.1002/oby.21117
   KELLEY DE, 1994, J CLIN INVEST, V94, P2349, DOI 10.1172/JCI117600
   Khalili L, 2021, METABOLITES, V11, DOI 10.3390/metabo11110742
   Khalyfa A, 2013, INT J OBESITY, V37, P1481, DOI 10.1038/ijo.2013.12
   Kouki R, 2012, NUTR METAB CARDIOVAS, V22, P553, DOI 10.1016/j.numecd.2010.10.008
   Krammer UDB, 2022, SPORTS, V10, DOI 10.3390/sports10050073
   Lanaspa MA, 2012, J BIOL CHEM, V287, P40732, DOI 10.1074/jbc.M112.399899
   Lankinen M, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005258
   Lasa A, 2014, EUR J CLIN NUTR, V68, P767, DOI 10.1038/ejcn.2014.1
   Law BA, 2018, FASEB J, V32, P1403, DOI 10.1096/fj.201700300R
   Lee K, 2018, MOL CELL PROTEOMICS, V17, P2371, DOI 10.1074/mcp.RA118.000961
   LEE Y, 1994, P NATL ACAD SCI USA, V91, P10878, DOI 10.1073/pnas.91.23.10878
   Li JY, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/9196232
   Li N, 2019, FOOD FUNCT, V10, P4557, DOI 10.1039/c9fo00323a
   Liang MY, 2021, REV CARDIOVASC MED, V22, P1523, DOI 10.31083/j.rcm2204156
   Liang XJ, 2016, J BIOL CHEM, V291, P25306, DOI 10.1074/jbc.M116.749424
   Libert DM, 2018, PEERJ, V6, DOI 10.7717/peerj.5410
   Gutiérrez-Solis AL, 2018, METAB SYNDR RELAT D, V16, P395, DOI 10.1089/met.2017.0157
   Lin YH, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0260550
   Liu R, 2020, J NUTR BIOCHEM, V79, DOI 10.1016/j.jnutbio.2019.108330
   Liu X, 2016, OBESITY, V24, P2261, DOI 10.1002/oby.21584
   London E, 2020, J ENDOCRINOL, V246, pR51, DOI 10.1530/JOE-20-0035
   Lu X, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-48
   Malik AN, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8101222
   Malik VS, 2010, DIABETES CARE, V33, P2477, DOI 10.2337/dc10-1079
   Meex RCR, 2010, DIABETES, V59, P572, DOI 10.2337/db09-1322
   Meyer JG, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0208973
   Middleton P, 2021, THER ADV GASTROENTER, V14, DOI 10.1177/17562848211031394
   Mihalik SJ, 2010, OBESITY, V18, P1695, DOI 10.1038/oby.2009.510
   Miyagawa Y, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0908-0
   Mori TA, 2000, REDOX REP, V5, P45, DOI 10.1179/rer.2000.5.1.45
   Mumme K, 2015, J ACAD NUTR DIET, V115, P249, DOI 10.1016/j.jand.2014.10.022
   Narayanankutty A, 2018, J SCI FOOD AGR, V98, P1757, DOI [10.1002/jsfa.8650, 10.1002/jsfa.8]
   Narayanankutty A, 2016, J FOOD SCI TECH MYS, V53, P895, DOI 10.1007/s13197-015-2040-8
   Neeland IJ, 2018, DIABETOLOGIA, V61, P2570, DOI 10.1007/s00125-018-4720-1
   Nikniaz L, 2022, BMC ENDOCR DISORD, V22, DOI 10.1186/s12902-022-00963-2
   Nikooei P, 2021, NUTR METAB CARDIOVAS, V31, P939, DOI 10.1016/j.numecd.2020.11.020
   Ntzouvani A, 2017, NUTR METAB CARDIOVAS, V27, P1021, DOI 10.1016/j.numecd.2017.07.006
   O'Mahoney LL, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0740-x
   Oguoma VM, 2015, PUBLIC HEALTH, V129, P413, DOI 10.1016/j.puhe.2015.01.017
   Ostman C, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-017-0590-y
   Panth N, 2018, AM J CLIN NUTR, V108, P675, DOI 10.1093/ajcn/nqy167
   Parihar A, 2010, BBA-GEN SUBJECTS, V1800, P646, DOI 10.1016/j.bbagen.2010.03.022
   Park S, 2017, INT J FOOD SCI NUTR, V68, P479, DOI 10.1080/09637486.2016.1252318
   Pastor R, 2021, FREE RADICAL BIO MED, V172, P372, DOI 10.1016/j.freeradbiomed.2021.06.017
   Patti AM, 2020, METABOLITES, V10, DOI 10.3390/metabo10100392
   Phielix E, 2010, DIABETOLOGIA, V53, P1714, DOI 10.1007/s00125-010-1764-2
   Pieczenik SR, 2007, EXP MOL PATHOL, V83, P84, DOI 10.1016/j.yexmp.2006.09.008
   Pinel A, 2016, BBA-MOL CELL BIOL L, V1861, P12, DOI 10.1016/j.bbalip.2015.10.003
   Pirola CJ, 2021, J INTERN MED, V289, P84, DOI 10.1111/joim.13147
   Porter C, 2015, MED SCI SPORT EXER, V47, P1922, DOI 10.1249/MSS.0000000000000605
   Portillo MP, 1998, INT J OBESITY, V22, P974, DOI 10.1038/sj.ijo.0800706
   Poss AM, 2022, MED-CAMBRIDGE, V3, P452, DOI 10.1016/j.medj.2022.05.011
   Powers SK, 2020, J SPORT HEALTH SCI, V9, P415, DOI 10.1016/j.jshs.2020.04.001
   Raichur S, 2014, CELL METAB, V20, P687, DOI 10.1016/j.cmet.2014.09.015
   Ranasinghe P, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4041-1
   Rivas DA, 2012, J APPL PHYSIOL, V113, P1727, DOI 10.1152/japplphysiol.00412.2012
   Rodríguez LA, 2016, PUBLIC HEALTH NUTR, V19, P2424, DOI 10.1017/S1368980016000057
   Ronis MJJ, 2013, EXP BIOL MED, V238, P151, DOI 10.1258/ebm.2012.012303
   Rousseau M, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010173
   Sage AT, 2012, OBESITY, V20, P748, DOI 10.1038/oby.2011.144
   Sajan MP, 2012, METABOLISM, V61, P459, DOI 10.1016/j.metabol.2011.12.008
   Salas-Salvadó J, 2011, DIABETES CARE, V34, P14, DOI 10.2337/dc10-1288
   Satapati S, 2012, J LIPID RES, V53, P1080, DOI 10.1194/jlr.M023382
   SCALFI L, 1991, AM J CLIN NUTR, V53, P1130, DOI 10.1093/ajcn/53.5.1130
   Schönfeld P, 2016, J LIPID RES, V57, P943, DOI 10.1194/jlr.R067629
   Schooneman MG, 2013, DIABETES, V62, P1, DOI 10.2337/db12-0466
   Schulz N, 2011, ENDOCRINOLOGY, V152, P4641, DOI 10.1210/en.2011-1547
   Schwingshackl L, 2017, NUTR DIABETES, V7, DOI 10.1038/nutd.2017.12
   Scuteri A, 2015, EUR J PREV CARDIOL, V22, P486, DOI 10.1177/2047487314525529
   Seidelmann SB, 2018, LANCET PUBLIC HEALTH, V3, pE419, DOI 10.1016/S2468-2667(18)30135-X
   Semnani-Azad Z, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.9993
   Shi H, 2006, J CLIN INVEST, V116, P3015, DOI 10.1172/JCI28898
   Silva LA, 2009, EUR J APPL PHYSIOL, V105, P861, DOI 10.1007/s00421-008-0971-8
   Siskind LJ, 2010, J BIOL CHEM, V285, P11818, DOI 10.1074/jbc.M109.078121
   Sookoian S, 2016, AM J CLIN NUTR, V103, P422, DOI 10.3945/ajcn.115.118695
   Sookoian S, 2010, HEPATOLOGY, V52, P1992, DOI 10.1002/hep.23927
   St-Onge MP, 2008, J AM COLL NUTR, V27, P547, DOI 10.1080/07315724.2008.10719737
   St-Onge MP, 2003, OBES RES, V11, P395, DOI 10.1038/oby.2003.53
   Ströher DJ, 2020, J MED FOOD, V23, P689, DOI 10.1089/jmf.2019.0172
   STUBBS CD, 1984, BIOCHIM BIOPHYS ACTA, V779, P89, DOI 10.1016/0304-4157(84)90005-4
   Sunny NE, 2011, CELL METAB, V14, P804, DOI 10.1016/j.cmet.2011.11.004
   Sureda A, 2016, MOL NUTR FOOD RES, V60, P2654, DOI 10.1002/mnfr.201600450
   Taltavull N, 2016, FOOD FUNCT, V7, P3981, DOI [10.1039/C6FO00589F, 10.1039/c6fo00589f]
   Tan CY, 2008, BIOCHEM SOC T, V36, P935, DOI 10.1042/BST0360935
   Teng M, 2020, NUTR REV, V78, P249, DOI 10.1093/nutrit/nuz074
   Tham YY, 2020, MOL BIOL REP, V47, P9595, DOI 10.1007/s11033-020-06019-9
   Tochikubo O, 2016, NUTR DIABETES, V6, DOI 10.1038/nutd.2016.5
   Tominaga H, 2008, AM J PHYSIOL-HEART C, V295, pH105, DOI 10.1152/ajpheart.01307.2007
   van Vliet-Ostaptchouk JV, 2014, BMC ENDOCR DISORD, V14, DOI 10.1186/1472-6823-14-9
   Venturini D, 2015, NUTRITION, V31, P834, DOI 10.1016/j.nut.2014.12.016
   Voisin S, 2015, EUR J HUM GENET, V23, P654, DOI 10.1038/ejhg.2014.139
   Vona R, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8267234
   Walker ME, 2020, AM J CLIN NUTR, V111, P420, DOI 10.1093/ajcn/nqz257
   Wang DD, 2017, CIRCULATION, V135, P2028, DOI [10.1161/CIRCULATIONAHA.116.024261, 10.1161/circulationaha.116.024261]
   Warren JL, 2020, MED SCI SPORT EXER, V52, P827, DOI 10.1249/MSS.0000000000002190
   Weng LM, 2015, METAB SYNDR RELAT D, V13, P195, DOI 10.1089/met.2014.0132
   Wewege MA, 2018, ATHEROSCLEROSIS, V274, P162, DOI 10.1016/j.atherosclerosis.2018.05.002
   White PJ, 2010, DIABETES, V59, P3066, DOI 10.2337/db10-0054
   Yakeu G, 2010, ATHEROSCLEROSIS, V212, P668, DOI 10.1016/j.atherosclerosis.2010.07.002
   Yamaguchi N, 2017, ENVIRON HEALTH PREV, V22, DOI 10.1186/s12199-017-0642-7
   Yamakado M, 2015, SCI REP-UK, V5, DOI 10.1038/srep11918
   Yamazaki M, 2016, LIFE SCI, V149, P146, DOI 10.1016/j.lfs.2016.02.020
   Yin XY, 2016, J CLIN ENDOCR METAB, V101, P1779, DOI 10.1210/jc.2015-2555
   Yu J, 2007, J BIOL CHEM, V282, P25940, DOI 10.1074/jbc.M701812200
   Zhang X, 2021, PUBLIC HEALTH NUTR, V24, P3892, DOI 10.1017/S1368980020003614
   Zhang Y, 2011, METABOLISM, V60, P767, DOI 10.1016/j.metabol.2010.07.026
   Zheng LD, 2015, CLIN EPIGENETICS, V7, DOI 10.1186/s13148-015-0093-1
NR 163
TC 17
Z9 18
U1 1
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2023
VL 15
IS 5
AR 1217
DI 10.3390/nu15051217
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 9T4EM
UT WOS:000946981300001
PM 36904216
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cattafesta, M
   Salaroli, LB
AF Cattafesta, Monica
   Salaroli, Luciane Bresciani
TI Diets high in vegetables, fruits, cereals, and tubers as a protective
   factor for metabolic syndrome in bank employees
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE metabolic syndrome; dietary patterns; food consumption; workers; bank
   employees
ID INSULIN-RESISTANCE; NATIONAL-HEALTH; PATTERNS; PREVALENCE; STRESS;
   ASSOCIATION; VITORIA
AB Background: The prevalence of metabolic syndrome (MetS) is increasing, and its development may be related to westernized diets and working conditions.
   Purpose: The purpose of this study was to evaluate the association of dietary patterns in bank employees with the presence of MetS, considering sociodemographic and behavioral factors as well as laboratory tests.
   Subjects and methods: This was a cross-sectional study of 515 bankers. Sociodemographic, occupational, behavioral, and food consumption data were collected. Dietary patterns were determined by principal component analysis with orthogonal varimax rotation.
   Results: The dietary pattern of vegetables, fruits, cereals, and tubers was correlated with the presence of MetS and with waist circumference measurements and triglyceride levels. Individuals in the third and fifth quintiles of the pattern "vegetables, fruits, cereals, and tubers" presented with 3.28 and 2.24 times less chances of MetS when compared to individuals in the first quintile of this dietary pattern (OR 0.30, 95% CI 0.13-0.67, and OR 0.44, 95% CI 0.21-0.92, respectively). Subjects over 45 years of age were almost twice as likely to develop MetS (OR 1.95, 95% CI 1.01-3.77).
   Conclusion: Healthy eating represented by the dietary pattern "vegetables, fruits, cereals, and tubers" was associated with better health among bank employees, especially when evaluating competing metabolic complications such as MetS.
C1 [Cattafesta, Monica] Univ Fed Espirito Santo, Postgrad Program Publ Hlth, Vitoria, Espirito Santo, Brazil.
   [Salaroli, Luciane Bresciani] Univ Fed Espirito Santo, Postgrad Program Publ Hlth, Postgrad Program Nutr & Hlth, Dept Hlth Integrated Educ, Vitoria, Espirito Santo, Brazil.
C3 Universidade Federal do Espirito Santo; Universidade Federal do Espirito
   Santo
RP Salaroli, LB (corresponding author), Univ Fed Espirito Santo, Dept Hlth Integrated Educ, Marechal Campos Ave,1468,Maruipe, BR-29047105 Vitoria, ES, Brazil.
EM lucianebresciani@gmail.com
RI Salaroli, Luciane/Z-1241-2018; Cattafesta, Monica/KIB-7830-2024
OI Cattafesta, Monica/0000-0002-8973-622X; Salaroli,
   Luciane/0000-0002-1881-0306
FU Foundation for Support to Research and Innovation of Espirito Santo
FX The authors would like to thank the bank for their support in all stages
   of this study and the Foundation for Support to Research and Innovation
   of Espirito Santo for their granted scholarship.
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Alves MGD, 2004, REV SAUDE PUBL, V38, P164, DOI 10.1590/S0034-89102004000200003
   [Anonymous], CIEN SAUDE COLET
   [Anonymous], 2013, CLINICS, DOI DOI 10.6061/clinics/2013(01)OA11
   [Anonymous], 2020, Arq Bras Cardiol
   [Anonymous], MORTALIDADE DOENCAS
   [Anonymous], CLASS NIV AT FIS IPA
   [Anonymous], REV SAUDE PUBLICA
   [Anonymous], WHO UK FOOD STAND AG
   Associacao Brasileira de Empresas de Pesquisa (ABEP), 2003, CRIT CLASS EC BRAS C
   Baxter AJ, 2006, ASIA PAC J CLIN NUTR, V15, P134
   Cameron N, 1984, MEASUREMENT HUMAN GR
   Cattafesta M, 2016, DIABET METAB SYND OB, V9, P137, DOI 10.2147/DMSO.S101283
   de Almeida ALC, 2014, ARQ BRAS CARDIOL, V102, P327
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   Chung SW, 2013, KOREAN J FAM MED, V34, P420, DOI 10.4082/kjfm.2013.34.6.420
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Eilat-Adar S, 2013, NUTR METAB CARDIOVAS, V23, P528, DOI 10.1016/j.numecd.2011.12.005
   Ellis Amy, 2013, Journal of Nutrition in Gerontology and Geriatrics, V32, P263, DOI 10.1080/21551197.2013.842199
   Esmaillzadeh A, 2007, AM J CLIN NUTR, V85, P910, DOI 10.1093/ajcn/85.3.910
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Franca SL, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0167320
   Castanho GKF, 2013, CIENC SAUDE COLETIVA, V18, P385, DOI 10.1590/S1413-81232013000200010
   Montalvo IAG, 2018, NUTR HOSP, V35, P582, DOI 10.20960/nh.1504
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Ha S, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0174567
   Hair J.F., 2009, AN LISE MULTIVARIADA, V6a
   Hallal PC, 2010, J PHYS ACT HEALTH, V7, pS259, DOI 10.1123/jpah.7.s2.s259
   Jafari-Vayghan H, 2015, J AM COLL NUTR, V34, P49, DOI 10.1080/07315724.2014.880389
   Karasek RA, 1990, Healthy work: Stress, productivity, and the reconstruction of working life
   Karwautz A, 2013, NEUROPSYCHIATRIE, V27, P1, DOI 10.1007/s40211-013-0058-6
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Li XT, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0188533
   Li ZX, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0154990
   Massarani FA, 2015, CAD SAUDE PUBLICA, V31, P2535, DOI 10.1590/0102-311X00090314
   Matsudo S., 2012, Rev Bras Ativ Fis Saude Internet, V6, P5, DOI DOI 10.12820/RBAFS.V.6N2P5-18
   Moratoya E. E., 2013, Revista de Politica Agricola, V22, P72
   Narasimhan Sowmya, 2016, Indian J Endocrinol Metab, V20, P47, DOI 10.4103/2230-8210.172248
   Olinto M., 2007, Padroes alimentares: analise de componentes principai, P213
   Petarli GB, 2015, CIENC SAUDE COLETIVA, V20, P3925, DOI 10.1590/1413-812320152012.01522015
   Reinaldo EDF, 2015, INTERCIENCIA, V40, P330
   Salaroli LB, 2007, ARQ BRAS ENDOCRINOL, V51, P1143, DOI 10.1590/S0004-27302007000700018
   Salaroli LB, 2017, CLINICS, V72, P224, DOI 10.6061/clinics/2017(04)06
   Sarmento RA, 2013, ARQ BRAS CARDIOL, V101, P240
   Scicchitano P, 2014, J FUNCT FOODS, V6, P11, DOI 10.1016/j.jff.2013.12.006
   Sichieri R, 1998, NUTR RES, V18, P1649, DOI 10.1016/S0271-5317(98)00151-1
   Sichieri Rosely, 2003, Cad. Saúde Pública, V19, pS47, DOI 10.1590/S0102-311X2003000700006
   Silva EC, 2011, CIENC SAUDE COLETIVA, V16, P663, DOI 10.1590/S1413-81232011000200030
   Syauqy A, 2018, NUTRIENTS, V10, DOI 10.3390/nu10020143
   Tadaki S, 2016, CIRC J, V80, P677, DOI 10.1253/circj.CJ-15-0942
   Telles Edward E., 2003, Racismo a Brasileira. Uma Nova Perspectiva Socioldgica Rio de Janeiro
   Vidigal FD, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-1198
   Willett W., 2013, Nutritional epidemiology, VThird, P529
   World Health Organization ( WHO), 1998, REPORT JOINT FAO WHO
   Yuan C, 2015, EUR J CLIN NUTR, V69, P1193, DOI 10.1038/ejcn.2015.77
NR 55
TC 8
Z9 8
U1 1
U2 4
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2018
VL 11
BP 781
EP 790
DI 10.2147/DMSO.S184716
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HB8VI
UT WOS:000451368700001
PM 30538515
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lee, KS
   Lee, SG
   Kim, EK
   Jin, HJ
   Im, SU
   Lee, HK
   Merchant, AT
   Song, KB
   Choi, YH
AF Lee, Kyeong-Soo
   Lee, Sang Gyu
   Kim, Eun-Kyong
   Jin, Hye-Jung
   Im, Sang-Uk
   Lee, Hee-Kyung
   Merchant, Anwar T.
   Song, Keun-Bae
   Choi, Youn-Hee
TI Metabolic Syndrome Parameters in adolescents may be determinants for the
   future periodontal diseases
SO JOURNAL OF CLINICAL PERIODONTOLOGY
LA English
DT Article
DE adolescent; gingivitis; metabolic syndrome parameters
ID NUTRITION EXAMINATION SURVEY; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   NATIONAL-HEALTH; OBESITY; ASSOCIATION; CHILDREN; PREVALENCE;
   INFLAMMATION; SENSITIVITY
AB AimThe prevalence of metabolic syndrome (MetS) increases even in adolescents. The evidence that MetS is associated with the periodontal diseases in adolescents has been understudied. Therefore, our aim was to assess the association between MetS parameters and gingivitis in adolescents.
   Material and methodsA total of 941 participants (590 boys, 351 girls), aged 12-18years was selected from the Fourth Korea National Health and Nutrition Examination Survey, a cross-sectional and nationally representative survey, which had had information on waist circumference, blood pressure, serum triglyceride, high-density lipoprotein (HDL) cholesterol, and the fasting blood sugar and community periodontal Index (CPI).
   ResultsThe number of positive parameters of MetS showed significant positive correlation with gingivitis; adjusted and crude ORs with one positive parameters of MetS were 1.92 (95% CI: 1.21-3.04) and 1.88(95% CI: 1.28-2.76), respectively. And adjusted OR with three or more positive parameters of MetS was 3.29 (95% CI: 1.24-8.71). Among five parameters of MetS, Low HDL-cholesterol showed significant association with gingivitis (crude OR 2.12, 95% CI 1.20-3.73; adjusted OR 1.96, 95% CI 1.24-3.12).
   ConclusionsHaving more positive parameters of MetS and low HDL-cholesterol parameter had an independent relationship with the prevalence of gingivitis, which may be determinants for the future periodontal diseases even in adolescents.
C1 [Lee, Kyeong-Soo] Yeungnam Univ, Dept Prevent Med & Publ Hlth, Coll Med, Daegu, South Korea.
   [Lee, Sang Gyu] Yonsei Univ, Grad Sch Publ Hlth, Seoul 120749, South Korea.
   [Kim, Eun-Kyong] Kyungpook Natl Univ, Coll Sci & Technol, Dept Dent Hyg, Sangju, South Korea.
   [Jin, Hye-Jung] Dong Eui Univ, Dept Dent Hyg, Pusan, South Korea.
   [Im, Sang-Uk; Song, Keun-Bae; Choi, Youn-Hee] Kyungpook Natl Univ, Sch Dent, Dept Prevent Dent, Daegu, South Korea.
   [Lee, Hee-Kyung] Yeungnam Univ, Coll Med, Dept Dent, Daegu, South Korea.
   [Merchant, Anwar T.] Univ S Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA.
C3 Yeungnam University; Yonsei University; Yonsei University Health System;
   Kyungpook National University (KNU); Dong-Eui University; Kyungpook
   National University (KNU); Yeungnam University; University of South
   Carolina System; University of South Carolina Columbia
RP Choi, YH (corresponding author), 2177 Dalgubeol Daero, Daegu 700412, South Korea.
EM cyh1001@knu.ac.kr
RI Lee, Seung Eun/ABG-1607-2021; Lee, Sang Gyu/JQV-6912-2023; Merchant,
   Anwar/B-5233-2009
OI Lee, Kyeong Soo/0000-0001-8183-9462; Lee, Sang Gyu/0000-0003-4847-2421;
   IM, sang-uk/0000-0002-1194-9145
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF) - Ministry of Science, ICT & Future Planning [2013010434]
FX The authors declare that they do not have a conflict of interest. This
   research was supported by Basic Science Research Program through the
   National Research Foundation of Korea (NRF) funded by the Ministry of
   Science, ICT & Future Planning (2013010434).
CR AINAMO J, 1982, INT DENT J, V32, P281
   AINAMO J, 1992, SCAND J DENT RES, V100, P39
   Al-Zahrani MS, 2005, J PERIODONTOL, V76, P1362, DOI 10.1902/jop.2005.76.8.1362
   [Anonymous], 1997, ORAL HLTH SURVEYS BA, V4th
   Armitage G C, 1999, Ann Periodontol, V4, P1, DOI 10.1902/annals.1999.4.1.1
   Bullon P, 2009, J DENT RES, V88, P503, DOI 10.1177/0022034509337479
   Cameron AJ, 2004, ENDOCRIN METAB CLIN, V33, P351, DOI 10.1016/j.ecl.2004.03.005
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Chaffee BW, 2010, J PERIODONTOL, V81, P1708, DOI 10.1902/jop.2010.100321
   Chapple ILC, 2007, PERIODONTOL 2000, V43, P160, DOI 10.1111/j.1600-0757.2006.00178.x
   Cook S, 2003, ARCH PEDIAT ADOL MED, V157, P821, DOI 10.1001/archpedi.157.8.821
   Crespo PS, 2007, PUBLIC HEALTH NUTR, V10, P1121, DOI 10.1017/S1368980007000596
   Cruz ML, 2004, J CLIN ENDOCR METAB, V89, P108, DOI 10.1210/jc.2003-031188
   D'Aiuto F, 2008, J CLIN ENDOCR METAB, V93, P3989, DOI 10.1210/jc.2007-2522
   Franchini R, 2011, J CLIN PERIODONTOL, V38, P1021, DOI 10.1111/j.1600-051X.2011.01770.x
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Grundy SM, 1999, AM J CARDIOL, V83, p25F
   Gungor N, 2004, PEDIATR RES, V55, p145A
   Higashi Y, 2008, HYPERTENSION, V51, P446, DOI 10.1161/HYPERTENSIONAHA.107.101535
   Huang TTK, 2007, APPL PHYSIOL NUTR ME, V32, P13, DOI 10.1139/h06-094
   Kassab P, 2011, EUR J ORAL SCI, V119, P156, DOI 10.1111/j.1600-0722.2011.00816.x
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Khader Y, 2008, J PERIODONTOL, V79, P2048, DOI [10.1902/jop.2008.080022, 10.1902/jop.2008.080022 ]
   Kim HM, 2007, DIABETES RES CLIN PR, V75, P111, DOI 10.1016/j.diabres.2006.04.009
   Korea Centers for Disease Control and Prevention, 2011, 4 KOR NAT HLTH NUTR
   Korea Centers for Disease Control and Prevention, 2008, 4 KOR NAT HLTH NUTR
   Korea Centers for Disease Control and Prevention, 2008, REP STAND NAT HLTH S, P10
   Korea Centers for Disease Control and Prevention, 2007, 2007 KOREAN CHILDREN
   Korea Centers for Disease Control and Prevention, 2007, GUID UT DAT 4 KOR NA
   Lindhe N., 1997, CLIN PERIODONTOLOGY
   Marchetti E, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-88
   Mariotti A, 1999, Ann Periodontol, V4, P7, DOI 10.1902/annals.1999.4.1.7
   Modéer T, 2011, INT J PEDIATR OBES, V6, pE264, DOI 10.3109/17477166.2010.495779
   Morita T, 2009, J PUBLIC HEALTH DENT, V69, P248, DOI 10.1111/j.1752-7325.2009.00130.x
   Moutsopoulos NM, 2006, ANN NY ACAD SCI, V1088, P251, DOI 10.1196/annals.1366.032
   Nishimura F, 2001, J DENT RES, V80, P1690, DOI 10.1177/00220345010800080201
   Nishimura F, 2003, J PERIODONTOL, V74, P97, DOI 10.1902/jop.2003.74.1.97
   Oliver RC, 1998, J PERIODONTOL, V69, P269, DOI 10.1902/jop.1998.69.2.269
   Page R.C., 1982, PERIODONTITIS MAN OT
   Pergher RNQ, 2010, J PEDIAT-BRAZIL, V86, P101, DOI 10.2223/JPED.1983
   Shimazaki Y, 2007, J DENT RES, V86, P271, DOI 10.1177/154405910708600314
   Weiss R, 2004, NEW ENGL J MED, V350, P2362, DOI 10.1056/NEJMoa031049
   Zimmet P, 2007, PEDIATR DIABETES, V8, P299, DOI 10.1111/j.1399-5448.2007.00271.x
NR 43
TC 20
Z9 20
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-6979
EI 1600-051X
J9 J CLIN PERIODONTOL
JI J. Clin. Periodontol.
PD FEB
PY 2015
VL 42
IS 2
BP 105
EP 112
DI 10.1111/jcpe.12338
PG 8
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA CB7AF
UT WOS:000349777600001
PM 25469423
OA Bronze
DA 2025-06-11
ER

PT J
AU Wagner, JG
   Allen, K
   Yang, HY
   Nan, B
   Morishita, M
   Mukherjee, B
   Dvonch, JT
   Spino, C
   Fink, GD
   Rajagopalan, S
   Sun, QH
   Brook, RD
   Harkema, JR
AF Wagner, James G.
   Allen, Katryn
   Yang, Hui-yu
   Nan, Bin
   Morishita, Masako
   Mukherjee, Bhramar
   Dvonch, J. Timothy
   Spino, Catherine
   Fink, Gregory D.
   Rajagopalan, Sanjay
   Sun, Qinghua
   Brook, Robert D.
   Harkema, Jack R.
TI Cardiovascular Depression in Rats Exposed to Inhaled Particulate Matter
   and Ozone: Effects of Diet-Induced Metabolic Syndrome
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
ID HEART-RATE-VARIABILITY; HIGH-FRUCTOSE DIET; AIR-POLLUTION; INSULIN
   SENSITIVITY; HYPERTENSIVE-RATS; HIGH-RISK; INHALATION; PARAMETERS;
   RESPONSES; OBESITY
AB BACKGROUND: High ambient levels of ozone (O-3) and fine particulate matter (PM2.5) are associated with cardiovascular morbidity and mortality, especially in people with pre-existing cardio-pulmonary diseases. Enhanced susceptibility to the toxicity of air pollutants may include individuals with metabolic syndrome (MetS).
   OBJECTIVE: We tested the hypothesis that cardiovascular responses to O-3 and PM2.5 will be enhanced in rats with diet-induced MetS.
   METHODS: Male Sprague-Dawley rats were fed a high-fructose diet (HFrD) to induce MetS and then exposed to O-3, concentrated ambient PM2.5, or the combination of O-3 plus PM2.5 for 9 days. Data related to heart rate (HR), HR variability (HRV), and blood pressure (BP) were collected.
   RESULTS: Consistent with MetS, HFrD rats were hypertensive and insulin resistant, and had elevated fasting levels of blood glucose and triglycerides. Decreases in HR and BP, which were found in all exposure groups, were greater and more persistent in HFrD rats compared with those fed a normal diet (ND). Coexposure to O-3 plus PM2.5 induced acute drops in HR and BP in all rats, but only ND rats adapted after 2 days. HFrD rats had little exposure-related changes in HRV, whereas ND rats had increased HRV during O-3 exposure, modest decreases with PM2.5, and dramatic decreases during O-3 plus PM2.5 coexposures.
   CONCLUSIONS: Cardiovascular depression in O-3- and PM2.5-exposed rats was enhanced and prolonged in rats with HFrD-induced MetS. These results in rodents suggest that people with MetS may be prone to similar exaggerated BP and HR responses to inhaled air pollutants.
C1 [Wagner, James G.; Harkema, Jack R.] Michigan State Univ, Dept Pathobiol & Diagnost Invest, E Lansing, MI 48824 USA.
   [Wagner, James G.; Allen, Katryn; Harkema, Jack R.] Michigan State Univ, Ctr Integrat Toxicol, E Lansing, MI 48824 USA.
   [Yang, Hui-yu; Nan, Bin; Mukherjee, Bhramar; Spino, Catherine] Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA.
   [Morishita, Masako; Dvonch, J. Timothy] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA.
   [Fink, Gregory D.] Michigan State Univ, Dept Pharmacol & Toxicol, E Lansing, MI 48824 USA.
   [Rajagopalan, Sanjay; Sun, Qinghua] Ohio State Univ, Coll Med, Davis Heart & Lung Res Inst, Columbus, OH 43210 USA.
   [Brook, Robert D.] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA.
C3 Michigan State University; Michigan State University; University of
   Michigan System; University of Michigan; University of Michigan System;
   University of Michigan; Michigan State University; University System of
   Ohio; Ohio State University; University of Michigan System; University
   of Michigan
RP Wagner, JG (corresponding author), Michigan State Univ, 1129 Farm Lane,Room 211, E Lansing, MI 48864 USA.
EM wagnerja@msu.edu
RI Sun, Qinghua/E-4167-2011; Dvonch, Joseph/K-3632-2013
OI Morishita, Masako/0000-0001-9934-2657
FU U.S. EPA STAR Clean Air Research Centers program [R83479701]; National
   Institute of Environmental Health Sciences [P30ES017885] Funding Source:
   NIH RePORTER
FX This project was supported by the U.S. EPA (R83479701) STAR Clean Air
   Research Centers program.
CR Alarie Y, 1973, CRC Crit Rev Toxicol, V2, P299, DOI 10.3109/10408447309082020
   [Anonymous], NIH PUBLICATION
   Baja ES, 2010, ENVIRON HEALTH PERSP, V118, P840, DOI 10.1289/ehp.0901396
   Balasubramanian P, 2013, NEUROTOXICOLOGY, V36, P106, DOI 10.1016/j.neuro.2012.02.016
   Brook RD, 2013, SCI TOTAL ENVIRON, V448, P66, DOI 10.1016/j.scitotenv.2012.07.034
   Cheng TJ, 2003, ENVIRON HEALTH PERSP, V111, P147, DOI 10.1289/ehp.5464
   Dubowsky SD, 2006, ENVIRON HEALTH PERSP, V114, P992, DOI 10.1289/ehp.8469
   Farraj AK, 2012, ENVIRON HEALTH PERSP, V120, P348, DOI 10.1289/ehp.1104244
   Farraj AK, 2011, AM J RESP CELL MOL, V44, P185, DOI 10.1165/rcmb.2009-0456OC
   Feinman RD, 2013, NUTR METAB, V10, DOI 10.1186/1743-7075-10-45
   Ford ES, 2010, J DIABETES, V2, P180, DOI 10.1111/j.1753-0407.2010.00078.x
   Grassi G, 2009, PROG CARDIOVASC DIS, V52, P31, DOI 10.1016/j.pcad.2009.05.007
   Guize L, 2008, ARCH CARDIOVASC DIS, V101, P577, DOI 10.1016/j.acvd.2008.06.011
   Hamade AK, 2009, AM J PHYSIOL-REG I, V296, pR1202, DOI 10.1152/ajpregu.90808.2008
   Hampel R, 2012, OCCUP ENVIRON MED, V69, P428, DOI 10.1136/oemed-2011-100179
   Harkema Jack R, 2004, Res Rep Health Eff Inst, P1
   Hoffmann B, 2012, ENVIRON HEALTH PERSP, V120, P241, DOI 10.1289/ehp.1103647
   Johns DO, 2012, ENVIRON HEALTH PERSP, V120, P1238, DOI 10.1289/ehp.1204939
   Kamal AS, 2011, INHAL TOXICOL, V23, P417, DOI 10.3109/08958378.2011.580387
   Lamb CM, 2012, TOXICOL SCI, V125, P558, DOI 10.1093/toxsci/kfr296
   Liao DP, 1998, DIABETES CARE, V21, P2116, DOI 10.2337/diacare.21.12.2116
   Mayer MA, 2007, NEUROSCI LETT, V423, P128, DOI 10.1016/j.neulet.2007.06.046
   Michigan Department of Environmental Quality, 2012, 2011 ANN AIR QUAL RE
   Min JY, 2009, SCI TOTAL ENVIRON, V407, P4807, DOI 10.1016/j.scitotenv.2009.05.028
   Moraes-Silva IC, 2013, J APPL PHYSIOL, V114, P786, DOI 10.1152/japplphysiol.00586.2012
   Morishita M, 2006, ATMOS ENVIRON, V40, P3823, DOI 10.1016/j.atmosenv.2006.03.005
   Movahed MR, 2007, DIABETES OBES METAB, V9, P276, DOI 10.1111/j.1463-1326.2006.00609.x
   O'Neill MS, 2005, CIRCULATION, V111, P2913, DOI 10.1161/CIRCULATIONAHA.104.517110
   Ostro B, 2006, ENVIRON HEALTH PERSP, V114, P29, DOI 10.1289/ehp.8335
   Park SK, 2010, ENVIRON HEALTH PERSP, V118, P1406, DOI 10.1289/ehp.0901778
   Patel J, 2009, INDIAN J BIOCHEM BIO, V46, P66
   Peel JL, 2011, ENVIRON HEALTH PERSP, V119, P1321, DOI 10.1289/ehp.1002739
   Pop-Busui R, 2012, J CARDIOVASC TRANSL, V5, P463, DOI 10.1007/s12265-012-9367-6
   Ren J, 1997, AM J PHYSIOL-HEART C, V273, pH2876, DOI 10.1152/ajpheart.1997.273.6.H2876
   Rohr AC, 2011, ENVIRON HEALTH PERSP, V119, P474, DOI 10.1289/ehp.1002831
   Schneider A, 2010, PART FIBRE TOXICOL, V7, DOI 10.1186/1743-8977-7-14
   Sirivelu MP, 2006, ENVIRON HEALTH PERSP, V114, P870, DOI 10.1289/ehp.8619
   Stanhope KL, 2012, ANNU REV MED, V63, P329, DOI 10.1146/annurev-med-042010-113026
   Stanhope KL, 2009, J CLIN INVEST, V119, P1322, DOI 10.1172/JCI37385
   Sun LX, 2013, PART FIBRE TOXICOL, V10, DOI 10.1186/1743-8977-10-43
   Tran LT, 2009, MOL CELL BIOCHEM, V332, P145, DOI 10.1007/s11010-009-0184-4
   UCHIYAMA I, 1989, ENVIRON RES, V48, P76, DOI 10.1016/S0013-9351(89)80087-8
   Watkinson WP, 2001, ENVIRON HEALTH PERSP, V109, P539, DOI 10.2307/3454666
   Zanobetti A, 2011, AM J RESP CRIT CARE, V184, P836, DOI 10.1164/rccm.201102-0227OC
NR 44
TC 58
Z9 73
U1 1
U2 41
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
   RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD JAN
PY 2014
VL 122
IS 1
BP 27
EP 33
DI 10.1289/ehp.1307085
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA AC6OT
UT WOS:000332644200015
PM 24169565
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bondia-Pons, I
   Pöhö, P
   Bozzetto, L
   Vetrani, C
   Patti, L
   Aura, AM
   Annuzzi, G
   Hyötyläinen, T
   Rivellese, AA
   Oresic, M
AF Bondia-Pons, Isabel
   Poho, Paivi
   Bozzetto, Lutgarda
   Vetrani, Claudia
   Patti, Lidia
   Aura, Anna-Marja
   Annuzzi, Giovanni
   Hyotylainen, Tuulia
   Rivellese, Angela Albarosa
   Oresic, Matej
TI Isoenergetic diets differing in their n-3 fatty acid and
   polyphenol content reflect different plasma and HDL-fraction lipidomic
   profiles in subjects at high cardiovascular risk
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Cardiovascular disease; n-3 fatty acids; Lipidomics; Plasmalogens;
   Polyphenols
ID METABOLIC SYNDROME; GREEN TEA; OXIDATIVE STRESS; HEALTH; INFLAMMATION;
   MARKERS; OBESITY
AB Scope: Dysregulation of lipid homeostasis is related to multiple major healthcare problems. The aim of this study was to investigate the effects of n-3 fatty acid (FA) and polyphenol rich diets on plasma and HDL fraction lipidomic profiles in subjects at high cardiovascular risk.
   Methods and results: Ultra performance LC coupled to quadrupole TOF/MS mass spectrometry global lipidomic profiling was applied to plasma and HDL fraction from an 8 wk randomized intervention with four isoenergetic diets, differing in their natural n-3 FA and polyphenols content, in 78 subjects with a high BMI, abdominal obesity, and at least one other feature of the metabolic syndrome. Dependency network analysis showed a different pattern of associations between lipidomics, dietary, and clinical variables after the dietary interventions. The most remarkable associations between variables were observed after the diet high in n-3 FA and polyphenols, as the inverse association between gallic acid intake and LDL cholesterol levels, which was indirectly associated with a HDL cluster exclusively comprised lysophospholipids.
   Conclusion: This is the first human randomized controlled trial showing direct and indirect associations with lipid molecular species and clinical variables of interest in the evaluation of the metabolic syndrome after diets naturally rich in polyphenols.
C1 [Bondia-Pons, Isabel; Poho, Paivi; Aura, Anna-Marja; Hyotylainen, Tuulia; Oresic, Matej] VTT Tech Res Ctr Finland, Espoo, Finland.
   [Bondia-Pons, Isabel] Univ Navarra, Dept Food Sci & Physiol, E-31080 Pamplona, Spain.
   [Bozzetto, Lutgarda; Vetrani, Claudia; Patti, Lidia; Annuzzi, Giovanni; Rivellese, Angela Albarosa] Univ Naples Federico II, Dept Clin Med & Surg, Naples, Italy.
   [Hyotylainen, Tuulia; Oresic, Matej] Steno Diabet Ctr, DK-2820 Gentofte, Denmark.
C3 VTT Technical Research Center Finland; University of Navarra; University
   of Naples Federico II; Steno Diabetes Center
RP Oresic, M (corresponding author), Steno Diabet Ctr, Niels Steensens Vej 2, DK-2820 Gentofte, Denmark.
EM mtjo@steno.dk
RI Bozzetto, Lutgarda/E-6271-2012; Oresic, Matej/K-7673-2016; Hyötyläinen,
   Tuulia/AAP-6266-2020; Vetrani, Claudia/D-3306-2018
OI Hyotylainen, Tuulia/0000-0002-1389-8302; Patti,
   Lidia/0000-0002-0674-4188; Aura, Anna-Marja/0000-0002-8926-4744;
   Bozzetto, Lutgarda/0000-0001-6549-4476; Vetrani,
   Claudia/0000-0001-8335-5939; Oresic, Matej/0000-0002-2856-9165
FU EU [FP7-KBBE-222639]
FX This work was supported by the EU-funded project ETHERPATHS
   (FP7-KBBE-222639, http://www.etherpaths.org/). I. B-P. is grateful to
   the Carlos III Health Institute of the Spanish Ministry of Health for
   her Sara Borrell postdoctoral contract. Dr. G. Peddinti is acknowledged
   for his guidance and assistance in bioinformatics analyses.
CR Annuzzi G, 2014, AM J CLIN NUTR, V99, P463, DOI 10.3945/ajcn.113.073445
   [Anonymous], J STAT SOFTWARE
   Braverman NE, 2012, BBA-MOL BASIS DIS, V1822, P1442, DOI 10.1016/j.bbadis.2012.05.008
   Brohée S, 2008, NAT PROTOC, V3, P1616, DOI 10.1038/nprot.2008.100
   Cha KH, 2012, J AGR FOOD CHEM, V60, P7152, DOI 10.1021/jf301047f
   Chen YK, 2011, J AGR FOOD CHEM, V59, P11862, DOI 10.1021/jf2029016
   Farooqui AA, 2004, PROSTAG LEUKOTR ESS, V71, P161, DOI 10.1016/j.plefa.2004.03.004
   Farooqui AA, 2010, MOL NEUROBIOL, V41, P267, DOI 10.1007/s12035-009-8091-y
   Hyötyläinen T, 2013, MOL NUTR FOOD RES, V57, P1306, DOI 10.1002/mnfr.201200759
   Kotronen A, 2009, DIABETOLOGIA, V52, P684, DOI 10.1007/s00125-009-1282-2
   Lankinen M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0022646
   Lankinen M, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005258
   Lee YA, 2008, J AGR FOOD CHEM, V56, P7781, DOI 10.1021/jf800639m
   Lee YA, 2007, J NUTR SCI VITAMINOL, V53, P287, DOI 10.3177/jnsv.53.287
   LOPESVIRELLA MF, 1977, CLIN CHEM, V23, P882
   Montagut G, 2010, J NUTR BIOCHEM, V21, P476, DOI 10.1016/j.jnutbio.2009.02.003
   Mozaffarian D, 2012, J NUTR, V142, p614S, DOI 10.3945/jn.111.149633
   Nygren H, 2011, METHODS MOL BIOL, V708, P247, DOI 10.1007/978-1-61737-985-7_15
   Paniagua JA, 2011, ATHEROSCLEROSIS, V218, P443, DOI 10.1016/j.atherosclerosis.2011.07.003
   Pinheiro J, 2007, R package version 3.1-157
   Puupponen-Pimiä R, 2013, MOL NUTR FOOD RES, V57, P2258, DOI 10.1002/mnfr.201300280
   Quehenberger O, 2010, J LIPID RES, V51, P3299, DOI 10.1194/jlr.M009449
   R Core Team R., 2013, R: A language and environment for statistical computing, DOI 10.1007/978-3-540-74686-7
   Rhee EP, 2011, J CLIN INVEST, V121, P1402, DOI 10.1172/JCI44442
   Schäfer J, 2005, BIOINFORMATICS, V21, P754, DOI 10.1093/bioinformatics/bti062
   Sears B, 2012, EUR REV MED PHARMACO, V16, P1137
   Sofi F, 2010, AM J CLIN NUTR, V92, P1189, DOI 10.3945/ajcn.2010.29673
   Uusitupa M, 2013, J INTERN MED, V274, P52, DOI 10.1111/joim.12044
   Velayutham P, 2008, CURR MED CHEM, V15, P1840
   Vetrani C, 2014, FOOD RES INT, V63, P233, DOI 10.1016/j.foodres.2014.01.018
   Wallner S, 2011, CHEM PHYS LIPIDS, V164, P573, DOI 10.1016/j.chemphyslip.2011.06.008
   Wang HF, 2011, OBESITY, V19, P2404, DOI 10.1038/oby.2011.234
   Yetukuri L, 2010, J LIPID RES, V51, P2341, DOI 10.1194/jlr.M006494
NR 33
TC 27
Z9 28
U1 0
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD SEP
PY 2014
VL 58
IS 9
BP 1873
EP 1882
DI 10.1002/mnfr.201400155
PG 10
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA AP2EQ
UT WOS:000341885700011
PM 24961394
DA 2025-06-11
ER

PT J
AU Berg, G
   Miksztowicz, V
   Schreier, L
AF Berg, Gabriela
   Miksztowicz, Veronica
   Schreier, Laura
TI Metalloproteinases in metabolic syndrome
SO CLINICA CHIMICA ACTA
LA English
DT Review
DE Metabolic syndrome; Metalloproteinases; Abdominal obesity;
   Atherosclerosis
ID LOW-DENSITY-LIPOPROTEIN; C-REACTIVE PROTEIN; FAMILIAL COMBINED
   HYPERLIPIDEMIA; INCREASED CIRCULATING LEVELS; MATRIX METALLOPROTEINASES;
   ADIPOSE-TISSUE; INCREASED EXPRESSION; CORONARY ATHEROSCLEROSIS; CELL
   PROLIFERATION; OXIDATIVE STRESS
AB Experimental and clinical evidence supports the concept that metalloproteinases (MMPs), beyond different physiologic functions, also play a role in the development and rupture of the atherosclerotic plaque. Interest in MMPs has been rapidly increasing during the last years, especially as they have been proposed as biomarkers of vulnerable plaques. Different components of the metabolic syndrome (MS) have been identified as possible stimulus for the synthesis and activity of MMPs, like pro-inflammatory and pro-oxidant state, hyperglycemia, hypertension and dyslipidemia. On the other hand, anti-inflammatory cytokines like adiponectin are inversely associated with MMPs. Among the several MMPs studied, collagenases (MMP-1 and MMP-8) and gelatinases (MMP-2 and MMP-9) are the most associated with MS. Our aim was to summarize and discuss the relation between different components of the MS on MMPs, as well as the effect of the cluster of the metabolic alterations itself. It also highlights the necessity of further studies, in both animals and humans, to elucidate the function of novel MMPs identified, as well as the role of the known enzymes in different steps of metabolic diseases. Understanding the mechanisms of MS impact on MMPs and vice versa is an interesting area of research that will positively enhance our understanding of the complexity of MS and atherosclerosis. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Berg, Gabriela; Miksztowicz, Veronica; Schreier, Laura] Univ Buenos Aires, Dept Clin Biochem, Lipids & Lipoprot Lab, Fac Pharm & Biochem,INFIBIOC, RA-1053 Buenos Aires, DF, Argentina.
C3 University of Buenos Aires
RP Berg, G (corresponding author), Junin 956,CABA 1113, Buenos Aires, DF, Argentina.
EM gaberg@ffyb.uba.ar
OI Berg, Gabriela/0000-0002-5787-8960
FU University of Buenos Aires, (Argentina) [UBACYT 01/2103, B-070]
FX This work was supported by Research Grants from the University of Buenos
   Aires, (Argentina) UBACYT 01/2103 and B-070.
CR Ahmed SH, 2006, CIRCULATION, V113, P2089, DOI 10.1161/CIRCULATIONAHA.105.573865
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Aquilante CL, 2007, CLIN CHIM ACTA, V379, P48, DOI 10.1016/j.cca.2006.12.006
   Bäck M, 2010, PROG CARDIOVASC DIS, V52, P410, DOI 10.1016/j.pcad.2009.12.002
   Baker AH, 2002, J CELL SCI, V115, P3719, DOI 10.1242/jcs.00063
   Blankenberg S, 2003, CIRCULATION, V107, P1579, DOI 10.1161/01.CIR.0000058700.41738.12
   Boden G, 2008, ENDOCRIN METAB CLIN, V37, P635, DOI 10.1016/j.ecl.2008.06.007
   Boden G, 2008, AM J PHYSIOL-ENDOC M, V295, pE692, DOI 10.1152/ajpendo.90370.2008
   Boden G, 2008, DIABETES, V57, P476, DOI 10.2337/db07-1261
   Bouvet C, 2005, HYPERTENSION, V45, P432, DOI 10.1161/01.HYP.0000154680.44184.01
   Browatzki M, 2005, J VASC RES, V42, P415, DOI 10.1159/000087451
   Brownlee M, 2005, DIABETES, V54, P1615, DOI 10.2337/diabetes.54.6.1615
   Bujak M, 2009, ARCH IMMUNOL THER EX, V57, P165, DOI 10.1007/s00005-009-0024-y
   Cameron AJ, 2004, ENDOCRIN METAB CLIN, V33, P351, DOI 10.1016/j.ecl.2004.03.005
   Cardellini M, 2009, DIABETES, V58, P2396, DOI 10.2337/db09-0280
   Carr MC, 2004, J CLIN ENDOCR METAB, V89, P2601, DOI 10.1210/jc.2004-0432
   Chavey C, 2003, J BIOL CHEM, V278, P11888, DOI 10.1074/jbc.M209196200
   Cheng M, 2008, CAN J CARDIOL, V24, P385, DOI 10.1016/S0828-282X(08)70602-0
   Choudhary S, 2006, ARTERIOSCL THROM VAS, V26, P2351, DOI 10.1161/01.ATV.0000239461.87113.0b
   Christiaens Valerie, 2006, Archives of Physiology and Biochemistry, V112, P254, DOI 10.1080/13813450601093567
   Chu MC, 2008, AM J OBSTET GYNECOL, V199, DOI 10.1016/j.ajog.2008.04.033
   Cicero AFG, 2007, ENDOTHELIUM-J ENDOTH, V14, P193, DOI 10.1080/10623320701606731
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   de Nooijer R, 2006, ARTERIOSCL THROM VAS, V26, P340, DOI 10.1161/01.ATV.0000197795.56960.64
   Deardorff R, 2009, BIOMARK MED, V3, P513, DOI 10.2217/BMM.09.60
   Death AK, 2003, ATHEROSCLEROSIS, V168, P263, DOI 10.1016/S0021-9150(03)00140-0
   Demeulemeester D, 2005, BIOCHEM BIOPH RES CO, V329, P105, DOI 10.1016/j.bbrc.2005.01.103
   Derosa G, 2010, MICROVASC RES, V79, P144, DOI 10.1016/j.mvr.2010.01.002
   Derosa G, 2009, CLIN INVEST MED, V32, pE124, DOI 10.25011/cim.v32i2.6030
   Fanjul-Fernández M, 2010, BBA-MOL CELL RES, V1803, P3, DOI 10.1016/j.bbamcr.2009.07.004
   Federici M, 2002, CIRCULATION, V106, P466, DOI 10.1161/01.CIR.0000023043.02648.51
   Flamant M, 2007, HYPERTENSION, V50, P212, DOI 10.1161/HYPERTENSIONAHA.107.089631
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Gomez DE, 1997, EUR J CELL BIOL, V74, P111
   Gonçalves FM, 2009, CLIN CHIM ACTA, V403, P173, DOI 10.1016/j.cca.2009.02.013
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Gummesson A, 2009, SCAND J CLIN LAB INV, V69, P636, DOI [10.3109/00365510902912747, 10.1080/00365510902912747]
   Gurjar MV, 1999, ARTERIOSCL THROM VAS, V19, P2871, DOI 10.1161/01.ATV.19.12.2871
   Harman-Boehm I, 2007, J CLIN ENDOCR METAB, V92, P2240, DOI 10.1210/jc.2006-1811
   Hu PF, 2006, ATHEROSCLEROSIS, V185, P347, DOI 10.1016/j.atherosclerosis.2005.06.011
   Huang Y, 1999, ARTERIOSCL THROM VAS, V19, P2640, DOI 10.1161/01.ATV.19.11.2640
   Humphrey JD, 2008, HYPERTENSION, V52, P195, DOI 10.1161/HYPERTENSIONAHA.107.103440
   Hwang JJ, 2009, ATHEROSCLEROSIS, V204, P293, DOI 10.1016/j.atherosclerosis.2008.08.019
   Johnson Jason Lee, 2007, Expert Rev Cardiovasc Ther, V5, P265, DOI 10.1586/14779072.5.2.265
   Kojima C, 2010, J ATHEROSCLER THROMB, V17, P97, DOI 10.5551/jat.1685
   Kowluru RA, 2009, FREE RADICAL BIO MED, V46, P1677, DOI 10.1016/j.freeradbiomed.2009.03.024
   KRAUSS RM, 1995, AM J CARDIOL, V75, pB53, DOI 10.1016/0002-9149(95)80012-H
   Kumada M, 2004, CIRCULATION, V109, P2046, DOI 10.1161/01.CIR.0000127953.98131.ED
   Laimer M, 2005, INT J OBESITY, V29, P498, DOI 10.1038/sj.ijo.0802897
   Lau DCW, 2006, CAN J CARDIOL, V22, p85B, DOI 10.1016/S0828-282X(06)70992-8
   Lehrke M, 2009, CARDIOVASC DIABETOL, V8, DOI 10.1186/1475-2840-8-50
   Lewandowski KC, 2006, J CLIN ENDOCR METAB, V91, P3123, DOI 10.1210/jc.2005-2789
   Lewandowski KC, 2006, J CLIN ENDOCR METAB, V91, P1173, DOI 10.1210/jc.2005-0648
   Li L, 2005, DIABETES, V54, P2227, DOI 10.2337/diabetes.54.7.2227
   Li ZH, 1996, AM J PATHOL, V148, P121
   Li-Saw-Hee FL, 2000, INT J CARDIOL, V75, P43, DOI 10.1016/S0167-5273(00)00274-6
   Lijnen HR, 2008, CARDIOVASC RES, V78, P286, DOI 10.1093/cvr/cvm007
   Lijnen HR, 2002, THROMB HAEMOSTASIS, V88, P345
   Lu M, 2006, ANGLE ORTHOD, V76, P598
   Lucero D, 2011, CLIN CHIM ACTA, V412, P587, DOI 10.1016/j.cca.2010.12.012
   Muzzio ML, 2009, ARCH MED RES, V40, P48, DOI 10.1016/j.arcmed.2008.10.011
   Maquoi E, 2002, DIABETES, V51, P1093, DOI 10.2337/diabetes.51.4.1093
   Maxwell PR, 2001, DIABETIC MED, V18, P777, DOI 10.1046/j.1464-5491.2001.00542.x
   Miksztowicz V, 2008, METABOLISM, V57, P1493, DOI 10.1016/j.metabol.2008.06.001
   Mo YQ, 2009, TOXICOLOGY, V262, P130, DOI 10.1016/j.tox.2009.05.019
   Muzzio ML, 2007, CLIN CHIM ACTA, V381, P157, DOI 10.1016/j.cca.2007.03.004
   Nagase H, 2006, CARDIOVASC RES, V69, P562, DOI 10.1016/j.cardiores.2005.12.002
   Nagase H, 2011, CURR PROTOC PROTEIN, V21, P1
   Nair S, 2005, DIABETOLOGIA, V48, P1784, DOI 10.1007/s00125-005-1868-2
   Nanni S, 2007, TRANSL RES, V149, P137, DOI 10.1016/j.trsl.2006.09.001
   Newby AC, 2005, PHYSIOL REV, V85, P1, DOI 10.1152/physrev.00048.2003
   Novaro V, 2001, REPROD FERT DEVELOP, V13, P411, DOI 10.1071/RD01036
   Oda Akihiko, 2001, Kobe Journal of Medical Sciences, V47, P141
   Otake H, 2008, AM J CARDIOL, V101, P1, DOI 10.1016/j.amjcard.2007.07.041
   Park HY, 2001, EXP MOL MED, V33, P95, DOI 10.1038/emm.2001.17
   Park JP, 2010, CIRC J, V74, P332, DOI 10.1253/circj.CJ-09-0570
   Pasarica M, 2009, DIABETES, V58, P718, DOI 10.2337/db08-1098
   Raffetto JD, 2008, BIOCHEM PHARMACOL, V75, P346, DOI 10.1016/j.bcp.2007.07.004
   Roy R, 2006, EXP CELL RES, V312, P608, DOI 10.1016/j.yexcr.2005.11.022
   Schieffer B, 2004, J AM COLL CARDIOL, V44, P362, DOI 10.1016/j.jacc.2004.03.065
   Schönbeck U, 1999, J EXP MED, V189, P843, DOI 10.1084/jem.189.5.843
   Schreier L, 2002, NUTR METAB CARDIOVAS, V12, P13
   Singh U, 2008, J LIPID RES, V49, P1015, DOI 10.1194/jlr.M700535-JLR200
   Siwik DA, 2000, CIRC RES, V86, P1259, DOI 10.1161/01.RES.86.12.1259
   Stracke JO, 2000, FEBS LETT, V478, P52, DOI 10.1016/S0014-5793(00)01819-6
   Sun JZ, 2009, MOL CELL ENDOCRINOL, V313, P64, DOI 10.1016/j.mce.2009.08.019
   Tarallo S, 2010, ACTA DIABETOL, V47, P105, DOI 10.1007/s00592-009-0124-5
   Tayebjee MH, 2004, AM J HYPERTENS, V17, P770, DOI 10.1016/j.amjhyper.2004.06.023
   Tedgui A, 2006, PHYSIOL REV, V86, P515, DOI 10.1152/physrev.00024.2005
   Thrailkill KM, 2007, DIABETES CARE, V30, P2321, DOI 10.2337/dc07-0162
   Uemura S, 2001, CIRC RES, V88, P1291, DOI 10.1161/hh1201.092042
   Unal R, 2010, J CLIN ENDOCR METAB, V95, P2993, DOI 10.1210/jc.2009-2623
   Uzui H, 2002, CIRCULATION, V106, P3024, DOI 10.1161/01.CIR.0000041433.94868.12
   Valentin F, 2005, FUND CLIN PHARMACOL, V19, P661, DOI 10.1111/j.1472-8206.2005.00371.x
   van Tits L, 2005, ARTERIOSCL THROM VAS, V25, P717, DOI 10.1161/01.ATV.0000157979.51673.2c
   Visse R, 2003, CIRC RES, V92, P827, DOI 10.1161/01.RES.0000070112.80711.3D
   Vu TH, 2000, GENE DEV, V14, P2123, DOI 10.1101/gad.815400
   Wisse BE, 2004, J AM SOC NEPHROL, V15, P2792, DOI 10.1097/01.ASN.0000141966.69934.21
   Xu XP, 1999, CIRCULATION, V99, P993, DOI 10.1161/01.CIR.99.8.993
NR 100
TC 47
Z9 48
U1 0
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD SEP 18
PY 2011
VL 412
IS 19-20
BP 1731
EP 1739
DI 10.1016/j.cca.2011.06.013
PG 9
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 813UU
UT WOS:000294396500005
PM 21703252
OA Green Published
DA 2025-06-11
ER

PT J
AU Freitas, RD
   Silva, CMD
   Fratelli, CF
   de Lima, LR
   Stival, MM
   Funghetto, SS
   da Silva, ICR
   de Andrade, RV
AF Freitas, Renata de Souza
   de Souza Silva, Calliandra Maria
   Ferreira Fratelli, Caroline
   Ramos de Lima, Luciano
   Morato Stival, Marina
   Schwerz Funghetto, Silvana
   Rodrigues da Silva, Izabel Cristina
   Vieira de Andrade, Rosangela
TI IL-10 and IL-1β Serum Levels, Genetic Variants, and Metabolic Syndrome:
   Insights into Older Adults' Clinical Characteristics
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; interlekine-10; interlekine-1 beta; older
   population; IL10 rs1800890; IL1B rs1143627
ID INTERLEUKIN-10; INFLAMMATION; ASSOCIATION; ADIPONECTIN; COMPONENTS;
   CYTOKINES; OBESITY; STRESS; SYSTEM; RISK
AB Populational aging is marked by chronic noncommunicable diseases, such as metabolic syndrome (MetS). IL-10 and IL-1 beta are pleiotropic cytokines with multiple biological effects linked to metabolic disorders. This cross-sectional study assessed 193 participants' IL-10 and IL-1 beta serum levels regarding their role in developing MetS, clinical characteristics, and their IL1B rs1143627 and IL10 rs1800890 variants' genotype frequencies in a population over 60. IL-10 levels correlated weakly with HDL levels and fat mass and inversely with triglycerides, glucose, glycated hemoglobin, and estimated average blood glucose levels. IL-10 levels were also indirectly influenced by the patient's T2DM duration, lean mass amount, and bone mineral content. Participants with altered HDL, elevated serum glucose, raised HbA1c levels, or those over 80 had reduced serum IL-10 levels compared to those with normal levels or other age groups, respectively. Women also had higher serum IL-10 levels than men. Dissimilarly, IL-1 beta levels correlated directly only with the number of total leukocytes and segmented neutrophils, showing only significant variations with self-reported alcohol consumption. Our study also found that those with the IL10 AA genotype (lower IL-10 levels) had a significantly higher risk of developing MetS. These findings may help direct future research and more targeted therapeutic approaches in older adults.
C1 [Freitas, Renata de Souza; Vieira de Andrade, Rosangela] Catholic Univ Brasilia UCB, Grad Program Genom Sci & Biotechnol, BR-72220900 Brasilia, DF, Brazil.
   [de Souza Silva, Calliandra Maria; Ferreira Fratelli, Caroline; Morato Stival, Marina; Schwerz Funghetto, Silvana; Rodrigues da Silva, Izabel Cristina] Univ Brasilia, Fac Ceilandia, Grad Program Hlth Sci & Technol, BR-72220900 Brasilia, DF, Brazil.
   [de Souza Silva, Calliandra Maria; Ramos de Lima, Luciano; Morato Stival, Marina; Schwerz Funghetto, Silvana; Rodrigues da Silva, Izabel Cristina] Univ Brasilia, Fac Ceilandia, BR-72220900 Brasilia, DF, Brazil.
C3 Universidade de Brasilia; Universidade de Brasilia
RP da Silva, ICR (corresponding author), Univ Brasilia, Fac Ceilandia, Grad Program Hlth Sci & Technol, BR-72220900 Brasilia, DF, Brazil.; da Silva, ICR (corresponding author), Univ Brasilia, Fac Ceilandia, BR-72220900 Brasilia, DF, Brazil.
EM belbiomedica@gmail.com; rosangelav@p.ucb.br
RI RODRIGUES DA SILVA, IZABEL CRISTINA/HLV-7294-2023; de Lima,
   Luiz/A-4927-2015
OI FREITAS, RENATA DE SOUZA/0000-0003-3563-6415
FU Coordenao de Aperfeioamento de Pessoal de Nvel Superior-Brasil (CAPES)
FX We are grateful to the patients for participating in this study.
CR Achur RN, 2010, J NEUROIMMUNE PHARM, V5, P83, DOI 10.1007/s11481-009-9185-z
   Acosta JR, 2019, J CLIN ENDOCR METAB, V104, P4552, DOI 10.1210/jc.2019-00341
   Afshar M, 2015, ALCOHOL, V49, P57, DOI 10.1016/j.alcohol.2014.10.002
   Ahmed B, 2021, BIOMED PHARMACOTHER, V137, DOI 10.1016/j.biopha.2021.111315
   Alves R, 2022, ACTA MEDICA PORT, V35, P633, DOI 10.20344/amp.15051
   Ashwood P, 2011, BRAIN BEHAV IMMUN, V25, P40, DOI 10.1016/j.bbi.2010.08.003
   Ballak DB, 2015, CYTOKINE, V75, P280, DOI 10.1016/j.cyto.2015.05.005
   Blüher M, 2005, EXP CLIN ENDOCR DIAB, V113, P534, DOI 10.1055/s-2005-872851
   Cho JS, 2012, PLOS PATHOG, V8, DOI 10.1371/journal.ppat.1003047
   Cruvinel WD, 2010, REV BRAS REUMATOL, V50, P434
   Dai ZM, 2015, GENET TEST MOL BIOMA, V19, P324, DOI 10.1089/gtmb.2015.0024
   Barbalho YGD, 2020, CLIN INTERV AGING, V15, P1691, DOI 10.2147/CIA.S252589
   Dziegielewska-Gesiak S, 2023, METABOLITES, V13, DOI 10.3390/metabo13040475
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Francischetti I, 2010, REV BRAS CIR CARDIOV, V25, P575, DOI 10.1590/S0102-76382010000400023
   Gao MM, 2013, MOL THER, V21, P1852, DOI 10.1038/mt.2013.125
   Garcia LP, 2020, CAD SAUDE PUBLICA, V36, DOI 10.1590/0102-311X00124520
   Grandl G, 2018, SEMIN IMMUNOPATHOL, V40, P215, DOI 10.1007/s00281-017-0666-5
   Gupta SC, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.02160
   Hussain M.K., 2011, Al-Mustansiriyah J. Sci, V22, P202
   Instituto Brasileiro de Geografia e Estatistica-IBGE, 2023, Censo 2022: numero de pessoas com 65 anos ou mais de idade cresceu 57,4% em 12 anos Internet
   Ip WKE, 2017, SCIENCE, V356, P513, DOI 10.1126/science.aal3535
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   LaMarche NM, 2020, CELL METAB, V32, P243, DOI 10.1016/j.cmet.2020.05.017
   Lins Maria Eduarda Morais, 2019, Saúde debate, V43, P520, DOI 10.1590/0103-1104201912118
   Liu CX, 2016, CYTOKINE, V86, P100, DOI 10.1016/j.cyto.2016.06.028
   Liu YS, 2018, BMC ENDOCR DISORD, V18, DOI 10.1186/s12902-018-0265-z
   Maedler K, 2011, HANDB EXP PHARMACOL, V203, P257, DOI 10.1007/978-3-642-17214-4_11
   Maiuolo J, 2021, FRONT CELL DEV BIOL, V9, DOI 10.3389/fcell.2021.651021
   McKeown RE, 2009, AM J LIFESTYLE MED, V3, p19S, DOI 10.1177/1559827609335350
   Monti D, 2017, MECH AGEING DEV, V165, P129, DOI 10.1016/j.mad.2016.12.008
   Moraitis AG, 2015, J CLIN LIPIDOL, V9, P81, DOI 10.1016/j.jacl.2014.09.014
   Nematollahi HR, 2019, ARYA ATHEROSCLER, V15, P233, DOI 10.22122/arya.v15i5.1623
   Netea MG, 2011, J CLIN ENDOCR METAB, V96, P1279, DOI 10.1210/jc.2011-0685
   Norde MM, 2018, CLIN NUTR, V37, P659, DOI 10.1016/j.clnu.2017.02.009
   Oliveira A. S., 2019, Revista Brasileira de Geografia, Medicina e da Sade, V31, P69, DOI [10.14393/Hygeia153248614, DOI 10.14393/HYGEIA153248614]
   da Fonseca HLP, 2019, CIENC SAUDE COLETIVA, V24, P1981, DOI 10.1590/1413-81232018246.07902019
   Ribeiro IS, 2019, EXP GERONTOL, V127, DOI 10.1016/j.exger.2019.110734
   Saraiva M, 2020, J EXP MED, V217, DOI 10.1084/jem.20190418
   Rossi JLS, 2022, DIABETES-METAB RES, V38, DOI 10.1002/dmrr.3502
   Simo AF., 2013, BRASILEIROS CARDIOL, V101, P63, DOI [10.5935/abc.2013S012, DOI 10.5935/ABC.2013S012]
   Subramanian N, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.996954
   Barcelos ALV, 2019, CLIN CHIM ACTA, V495, P394, DOI 10.1016/j.cca.2019.05.006
   Wang H, 2022, J REPROD IMMUNOL, V154, DOI 10.1016/j.jri.2022.103750
   Weiss TW, 2013, METABOLISM, V62, P1008, DOI 10.1016/j.metabol.2013.01.019
   Wiedemann SJ, 2022, CELL METAB, V34, P991, DOI 10.1016/j.cmet.2022.06.001
   Xu JL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0063654
   York A.G., bioRxiv, DOI DOI 10.1101/2023.05.07.539780
   Zahedi AS, 2023, HELIYON, V9, DOI 10.1016/j.heliyon.2023.e19911
NR 49
TC 3
Z9 3
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2024
VL 16
IS 8
AR 1241
DI 10.3390/nu16081241
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OZ9H7
UT WOS:001211211200001
PM 38674931
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Choi, JR
   Kim, JY
   Park, IH
   Huh, JH
   Kim, KW
   Cha, SK
   Park, KS
   Sohn, JH
   Park, JT
   Koh, SB
AF Choi, Jung Ran
   Kim, Jang-Young
   Park, Il Hwan
   Huh, Ji Hye
   Kim, Ki Woo
   Cha, Seung-Kuy
   Park, Kyu-Sang
   Sohn, Joon Hyung
   Park, Jong Taek
   Koh, Sang Baek
TI Serum Fibroblast Growth Factor 21 and New-Onset Metabolic Syndrome:
   KoGES-ARIRANG Study
SO YONSEI MEDICAL JOURNAL
LA English
DT Article
DE Metabolic syndrome; fibroblast growth factor 21; biomarker;
   population-based prospective study
ID ENDOPLASMIC-RETICULUM STRESS; FATTY LIVER-DISEASE; PPAR-ALPHA; OBESITY;
   FIBROBLAST-GROWTH-FACTOR-21; FGF21; PREVALENCE; REGULATOR; FGF-21;
   STATES
AB Purpose: Fibroblast growth factor 21 (FGF21) is a crucial metabolic regulator, with multiple favorable effects on glucose homeostasis and lipid metabolism. Since serum FGF21 level has been implicated as a potential marker for the early identification of metabolic syndrome (MetS), we investigated the association between serum FGF21 level and the development of MetS in a population- based prospective study.
   Materials and Methods: We conducted a prospective study of 221 randomly sampled adults without MetS from a general population- based cohort study who were examined from 2005-2008 (baseline) and from 2008-2011 (follow-up). Baseline serum FGF21 levels were analyzed using enzyme-linked immunosorbent assay.
   Results: During the average 2.8-year follow-up period, 82 participants (36.6%) developed new-onset MetS. Serum FGF21 levels were significantly higher in patients with new-onset MetS than in those without MetS (209.56 +/- 226.80 vs. 110.09 +/- 81.10, p<0.01). In multivariate adjusted models, the odds for MetS development were greater in patients with serum FGF21 levels in the highest quartile, compared to those in the lowest quartile (3.84, 95% confidence interval: 1.59-9.28).
   Conclusion: Serum FGF21 level was an independent predictor for new-onset MetS in a population-based prospective study.
C1 [Choi, Jung Ran; Kim, Jang-Young; Koh, Sang Baek] Yonsei Univ, Wonju Coll Med, Inst Genom Cohort, Wonju, South Korea.
   [Kim, Jang-Young; Huh, Ji Hye] Yonsei Univ, Wonju Coll Med, Dept Internal Med, 20 Ilsan Ro, Wonju 26426, South Korea.
   [Park, Il Hwan] Yonsei Univ, Wonju Coll Med, Dept Thorac & Cardiovasc Surg, Wonju, South Korea.
   [Kim, Ki Woo] Yonsei Univ, Wonju Coll Med, Dept Pharmacol, Wonju, South Korea.
   [Cha, Seung-Kuy; Park, Kyu-Sang; Sohn, Joon Hyung] Yonsei Univ, Wonju Coll Med, Mitohormesis Res Ctr, Wonju, South Korea.
   [Cha, Seung-Kuy; Park, Kyu-Sang] Yonsei Univ, Wonju Coll Med, Dept Physiol, Wonju, South Korea.
   [Park, Jong Taek] Yonsei Univ, Wonju Coll Med, Dept Anesthesiol & Pain Med, 20 Ilsan Ro, Wonju 26426, South Korea.
   [Koh, Sang Baek] Yonsei Univ, Wonju Coll Med, Dept Prevent Med, Wonju, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University; Yonsei
   University; Yonsei University; Yonsei University; Yonsei University;
   Yonsei University
RP Kim, JY (corresponding author), Yonsei Univ, Wonju Coll Med, Dept Internal Med, 20 Ilsan Ro, Wonju 26426, South Korea.; Park, JT (corresponding author), Yonsei Univ, Wonju Coll Med, Dept Anesthesiol & Pain Med, 20 Ilsan Ro, Wonju 26426, South Korea.
EM kimjang713@gmail.com; jtp999@yonsei.ac.kr
RI park, jun yeon/GPX-5293-2022; Cha, Seung-Kuy/ABA-9147-2022; Kim, Ki
   Woo/AAW-9645-2021; Kim, Nam Hoon/HNS-5794-2023
OI Kim, Jang Young/0000-0002-0813-7082; Kim, Ki Woo/0000-0002-7790-1515;
   Park, Kyu-Sang/0000-0003-0322-9807
FU Korea Centers for Disease Control and Prevention [2005-E71013-00,
   2006-E71002-00, 2007-E71013-00, 2008-E71004-00, 2009-E71006-00,
   2010-E71003-00]; Basic Science Research Program through the National
   Research Foundation of Korea (NRF) - Ministry of Education
   [2017R1D-1A3B03034119]; Medical Research Center Program
   [2017R1A5A2015369]
FX This study was supported in part by grants from the Korea Centers for
   Disease Control and Prevention (2005-E71013-00, 2006-E71002-00,
   2007-E71013-00, 2008-E71004-00, 2009-E71006-00, and 2010-E71003-00).This
   research was supported by the Basic Science Research Program through the
   National Research Foundation of Korea (NRF), funded by the Ministry of
   Education (2017R1D-1A3B03034119).This research was also supported by the
   Medical Research Center Program 2017R1A5A2015369.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Badman MK, 2007, CELL METAB, V5, P426, DOI 10.1016/j.cmet.2007.05.002
   Bagheri L, 2016, J RENAL INJ PREV, V5, P79, DOI 10.15171/jrip.2016.17
   Bobbert T, 2013, DIABETES CARE, V36, P145, DOI 10.2337/dc12-0703
   Cross DAE, 2014, CANCER DISCOV, V4, P1046, DOI 10.1158/2159-8290.CD-14-0337
   Domouzoglou EM, 2015, AM J PHYSIOL-HEART C, V309, pH1029, DOI 10.1152/ajpheart.00527.2015
   Dushay J, 2010, GASTROENTEROLOGY, V139, P456, DOI 10.1053/j.gastro.2010.04.054
   Fisher FM, 2010, DIABETES, V59, P2781, DOI 10.2337/db10-0193
   Inagaki T, 2007, CELL METAB, V5, P415, DOI 10.1016/j.cmet.2007.05.003
   Kharitonenkov A, 2005, J CLIN INVEST, V115, P1627, DOI 10.1172/JCI23606
   Kim SH, 2015, DIABETOLOGIA, V58, P809, DOI 10.1007/s00125-014-3475-6
   Lee SY, 2007, DIABETES RES CLIN PR, V75, P72, DOI 10.1016/j.diabres.2006.04.013
   Lim S, 2011, DIABETES CARE, V34, P1323, DOI 10.2337/dc10-2109
   Lin ZF, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015534
   Lucero D, 2017, CLIN CHIM ACTA, V473, P1, DOI 10.1016/j.cca.2017.08.006
   Lundåsen T, 2007, BIOCHEM BIOPH RES CO, V360, P437, DOI 10.1016/j.bbrc.2007.06.068
   Matuszek B, 2010, ENDOKRYNOL POL, V61, P50
   Moyers JS, 2007, J CELL PHYSIOL, V210, P1, DOI 10.1002/jcp.20847
   Muise ES, 2008, MOL PHARMACOL, V74, P403, DOI 10.1124/mol.108.044826
   Nestel P, 2007, ASIA PAC J CLIN NUTR, V16, P362
   Ong KL, 2012, J CLIN ENDOCR METAB, V97, P4701, DOI 10.1210/jc.2012-2267
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Reitman ML, 2007, CELL METAB, V5, P405, DOI 10.1016/j.cmet.2007.05.010
   Ryu JY, 2013, ANN OCCUP ENVIRON ME, V25, DOI 10.1186/2052-4374-25-13
   Shen Y, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-124
   Wente W, 2006, DIABETES, V55, P2470, DOI 10.2337/db05-1435
   Zhang FF, 2015, MOL ENDOCRINOL, V29, P1400, DOI 10.1210/me.2015-1155
   Zhang M, 2012, DNA CELL BIOL, V31, P547, DOI 10.1089/dna.2011.1302
   Zhang X, 2008, DIABETES, V57, P1246, DOI 10.2337/db07-1476
   Zhou ZQ, 2009, PUBLIC HEALTH NUTR, V12, P1061, DOI 10.1017/S1368980008003601
NR 30
TC 12
Z9 13
U1 0
U2 4
PU YONSEI UNIV COLL MEDICINE
PI SEOUL
PA 50-1 YONSEI-RO, SEODAEMUN-GU, SEOUL 120-752, SOUTH KOREA
SN 0513-5796
EI 1976-2437
J9 YONSEI MED J
JI Yonsei Med. J.
PD MAR
PY 2018
VL 59
IS 2
BP 287
EP 293
DI 10.3349/ymj.2018.59.2.287
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FW5MQ
UT WOS:000425361900017
PM 29436198
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Lamster, IB
   Pagan, M
AF Lamster, Ira B.
   Pagan, Michael
TI Periodontal disease and the metabolic syndrome
SO INTERNATIONAL DENTAL JOURNAL
LA English
DT Review
DE Periodontitis; metabolic syndrome; dysglycemia
ID INSULIN-RESISTANCE; DIABETES-MELLITUS; SYSTEMIC MARKERS; ASSOCIATION;
   INFLAMMATION; OBESITY; POPULATION; PATHOGENESIS; BURDEN; RISK
AB The metabolic syndrome (MetS) is a spectrum of conditions that increase the risk of cardiovascular disease and diabetes mellitus. The components of MetS include dysglycemia, visceral obesity, atherogenic dyslipidemia (elevated triglycerides and low levels of high-density lipoprotein) and hypertension. An association of periodontal disease and MetS has been suggested. This association is believed to be the result of systemic oxidative stress and an exuberant inflammatory response. When examined individually, the components of the MetS that are most closely related to the risk of periodontitis are dysglycemia and obesity, with lesser contributions by atherogenic dyslipidemia and hypertension. Data suggest that the odds of periodontitis increase with the number of MetS components present in an individual. The direction of the relationship between MetS and periodontal disease cannot currently be determined because the majority of studies are cross-sectional. The association between MetS and periodontitis, however, suggests that improved understanding of this association could promote interprofessional practice. Evidence suggests that periodontal therapy can reduce the levels of inflammatory mediators in serum. If this finding is confirmed, periodontal treatment could become part of therapy for MetS. Oral health providers who identify patients at risk for MetS could refer them to a medical provider, and physicians could refer patients to dentists to ensure that patients with MetS receive a dental evaluation and any necessary treatment. These clinical activities would improve both oral and general health outcomes.
C1 [Lamster, Ira B.] Columbia Univ, Dept Hlth Policy & Management, Mailman Sch Publ Hlth, New York, NY 10027 USA.
   [Pagan, Michael] Columbia Univ, Coll Dent Med, New York, NY USA.
C3 Columbia University; Columbia University
RP Lamster, IB (corresponding author), Columbia Univ, Dept Hlth Policy & Management, Mailman Sch Publ Hlth, New York, NY 10027 USA.
EM ibl1@cumc.columbia.edu
FU Leavitt Endowment at the Columbia University College of Dental Medicine;
   Colgate Oral Pharmaceuticals
FX Michael Pagan was supported by the Leavitt Endowment at the Columbia
   University College of Dental Medicine. This research was supported, in
   part, by Colgate Oral Pharmaceuticals.
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Andriankaja OM, 2010, AUST DENT J, V55, P252, DOI 10.1111/j.1834-7819.2010.01231.x
   [Anonymous], 2000, J Periodontol, V71 Suppl 5S, P853, DOI 10.1902/jop.2000.71.5-S.853
   [Anonymous], 2015, With Special Feature on Adults Aged 55-64
   Armitage G C, 1999, Ann Periodontol, V4, P1, DOI 10.1902/annals.1999.4.1.1
   Balkau B, 1999, DIABETIC MED, V16, P442
   Benguigui C, 2010, J CLIN PERIODONTOL, V37, P601, DOI 10.1111/j.1600-051X.2010.01571.x
   Bullon P, 2009, J DENT RES, V88, P503, DOI 10.1177/0022034509337479
   Bullon P, 2014, J PERIODONTOL, V85, pE1, DOI 10.1902/jop.2013.130319
   Chaffee BW, 2010, J PERIODONTOL, V81, P1708, DOI 10.1902/jop.2010.100321
   Chistiakov DA, 2016, EXP MOL PATHOL, V100, P220, DOI 10.1016/j.yexmp.2016.01.006
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cochran DL, 2008, J PERIODONTOL, V79, P1569, DOI 10.1902/jop.2008.080233
   D'Aiuto F, 2008, J CLIN ENDOCR METAB, V93, P3989, DOI 10.1210/jc.2007-2522
   Dandona P, 2004, TRENDS IMMUNOL, V25, P4, DOI 10.1016/j.it.2003.10.013
   De Toni S, 1997, ANN NY ACAD SCI, V832, P363
   Deshpande Kalyani, 2010, J Indian Soc Periodontol, V14, P207, DOI 10.4103/0972-124X.76917
   Einhorn D., 2003, ENDOCR PRACT, V9, P240
   El Kholy K, 2015, TRENDS ENDOCRIN MET, V26, P315, DOI 10.1016/j.tem.2015.03.001
   Ervin R Bethene, 2009, Natl Health Stat Report, P1
   FEINGOLD KR, 1992, J LIPID RES, V33, P1765
   Fukui N, 2012, J PERIODONTOL, V83, P1363, DOI 10.1902/jop.2012.110605
   Grossi S G, 1998, Ann Periodontol, V3, P51, DOI 10.1902/annals.1998.3.1.51
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Gurav Abhijit N, 2014, Dent Res J (Isfahan), V11, P1
   Han DH, 2010, J CLIN PERIODONTOL, V37, P609, DOI 10.1111/j.1600-051X.2010.01580.x
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Iwasaki M, 2016, GERODONTOLOGY, V33, P193, DOI 10.1111/ger.12135
   Kalburgi V, 2014, ANN MED HEALTH SCI R, V4, P388, DOI 10.4103/2141-9248.133465
   Kaye EK, 2016, J DENT RES, V95, P822, DOI 10.1177/0022034516641053
   Keller A, 2015, J PERIODONTOL, V86, P766, DOI 10.1902/jop.2015.140589
   Khader Y, 2008, J PERIODONTOL, V79, P2048, DOI [10.1902/jop.2008.080022, 10.1902/jop.2008.080022 ]
   Klein BEK, 2002, DIABETES CARE, V25, P1790, DOI 10.2337/diacare.25.10.1790
   Kononen E, 2014, PERIODONTOL, V65, P46
   Kornman KS, 2008, J PERIODONTOL, V79, P1560, DOI 10.1902/jop.2008.080213
   Kushiyama M, 2009, J PERIODONTOL, V80, P1610, DOI 10.1902/jop.2009.090218
   Kwon YE, 2011, J CLIN PERIODONTOL, V38, P781, DOI 10.1111/j.1600-051X.2011.01756.x
   Lalla E, 2011, NAT REV ENDOCRINOL, V7, P738, DOI 10.1038/nrendo.2011.106
   Lamster IB, 2014, J CLIN PERIODONTOL, V41, P1055, DOI 10.1111/jcpe.12307
   Lee KS, 2015, J CLIN PERIODONTOL, V42, P105, DOI 10.1111/jcpe.12338
   Lee KS, 2014, ARCH GERONTOL GERIAT, V58, P125, DOI 10.1016/j.archger.2013.08.011
   López NJ, 2012, J PERIODONTOL, V83, P267, DOI 10.1902/jop.2011.110227
   Marcenes W, 2013, J DENT RES, V92, P592, DOI 10.1177/0022034513490168
   Marchetti E, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-88
   Morita T, 2010, J PERIODONTOL, V81, P512, DOI 10.1902/jop.2010.090594
   Morita T, 2009, J PUBLIC HEALTH DENT, V69, P248, DOI 10.1111/j.1752-7325.2009.00130.x
   Nesbitt MJ, 2010, AGING CLIN EXP RES, V22, P238, DOI 10.1007/BF03324802
   Nibali L, 2013, J CLIN ENDOCR METAB, V98, P913, DOI 10.1210/jc.2012-3552
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Page RC, 2007, J PERIODONTOL, V78, P1387, DOI 10.1902/jop.2007.060264
   Pischon N, 2007, J DENT RES, V86, P400, DOI 10.1177/154405910708600503
   Preshaw PM, 2012, DIABETOLOGIA, V55, P21, DOI 10.1007/s00125-011-2342-y
   Saremi A, 2005, DIABETES CARE, V28, P27, DOI 10.2337/diacare.28.1.27
   Schenkein HA, 2013, J CLIN PERIODONTOL, V40, pS51, DOI [10.1902/jop.2013.134006, 10.1111/jcpe.12060]
   Shetty Neetha, 2008, J Indian Soc Periodontol, V12, P41, DOI 10.4103/0972-124X.44089
   Shimada Y, 2010, J PERIODONTOL, V81, P1118, DOI 10.1902/jop.2010.090741
   Shimazaki Y, 2007, J DENT RES, V86, P271, DOI 10.1177/154405910708600314
   Shultis WA, 2007, DIABETES CARE, V30, P306, DOI 10.2337/dc06-1184
   Suganami T, 2010, J LEUKOCYTE BIOL, V88, P33, DOI 10.1189/jlb.0210072
   Suresh S, 2014, J CLIN DIAGN RES, V8, pZE1, DOI 10.7860/JCDR/2014/7071.4227
   Suvan J, 2011, OBES REV, V12, pe381, DOI 10.1111/j.1467-789X.2010.00808.x
   Suvan JE, 2015, J CLIN PERIODONTOL, V42, P733, DOI 10.1111/jcpe.12421
   Tsioufis C, 2011, ATHEROSCLEROSIS, V219, P1, DOI 10.1016/j.atherosclerosis.2011.04.030
   Tu YK, 2013, J CLIN PERIODONTOL, V40, P994, DOI 10.1111/jcpe.12157
   Watanabe K, 2014, ARCH ORAL BIOL, V59, P855, DOI 10.1016/j.archoralbio.2014.05.003
   Wilcox Gisela, 2005, Clin Biochem Rev, V26, P19
   Wu YY, 2015, INT J ORAL SCI, V7, P63, DOI 10.1038/ijos.2015.2
   Yucel-Lindberg T, 2013, EXPERT REV MOL MED, V15, DOI 10.1017/erm.2013.8
NR 68
TC 117
Z9 129
U1 0
U2 17
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0020-6539
EI 1875-595X
J9 INT DENT J
JI Int. Dent. J.
PD APR
PY 2017
VL 67
IS 2
BP 67
EP 77
DI 10.1111/idj.12264
PG 11
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA EP5GF
UT WOS:000397406300001
PM 27861820
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Amin, F
   Gilani, AH
   Mehmood, MH
   Siddiqui, BS
   Khatoon, N
AF Amin, Faridah
   Gilani, Anwarul-Hassan
   Mehmood, Malik Hassan
   Siddiqui, Bina S.
   Khatoon, Nasima
TI Coadministration of Black Seeds and Turmeric Shows Enhanced Efficacy in
   Preventing Metabolic Syndrome in Fructose-fed Rats
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
LA English
DT Article
DE metabolic syndrome; fructose-fed rats; turmeric and black seeds
ID NIGELLA-SATIVA; INSULIN SENSITIVITY; WISTAR RATS; CURCUMIN; GLUCOSE;
   MODEL; INFLAMMATION; RELAXATION; STRESS; DAMAGE
AB Among noncommunicable diseases, metabolic syndrome (MS), a cluster of metabolic disorders including obesity, hyperglycemia, hyperlipidemia and hypertension, is highly prevalent in modern society. Its management requires lifestyle modifications and/or the life-long use of multiple medications, hence demanding development of safe alternative remedies. This study was aimed to establish the efficacy of combined use of black seeds and turmeric using fructose-fed rat model of MS. The high-performance liquid chromatographic fingerprints of turmeric and black seeds showed the presence of curcumin and thymoquinone, respectively, as their major constitutes. Different doses of black seeds and turmeric, individually and in combination, were administered to fructose-fed rats for up to 6 weeks representing characteristic features of MS. At 3 weeks of the treatment, black seeds and turmeric lowered (P < 0.01) high blood pressure and low-density lipoprotein cholesterol, respectively, whereas their coadministration reduced (P < 0.01) both high blood pressure and hypertriglyceridemia. At 6 weeks, the coadministration of both herbs, at half the doses of individual herbs, was the most effective (P < 0.001) in preventing hypertension, hyperglycemia, dyslipidemia, hyperinsulinemia, and endothelial dysfunction than the individual herbs. This study demonstrates the therapeutic superiority of the combination of black seeds and turmeric at low doses over individually tested herbs, in improving features of MS.
C1 [Amin, Faridah; Gilani, Anwarul-Hassan; Mehmood, Malik Hassan] Aga Khan Univ, Coll Med, Dept Biol & Biomed Sci, Karachi 74800, Pakistan.
   [Siddiqui, Bina S.; Khatoon, Nasima] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 32, Pakistan.
   [Gilani, Anwarul-Hassan] Mekelle Univ, Coll Hlth Sci, Mekelle, Ethiopia.
C3 Aga Khan University; University of Karachi; Mekelle University
RP Gilani, AH (corresponding author), Aga Khan Univ, Coll Med, Dept Biol & Biomed Sci, Karachi 74800, Pakistan.
EM anwar.gilani@aku.edu
RI Mehmood, Dr Malik Hassan/KCJ-4885-2024; Siddiqui, bina/F-2475-2015;
   Gilani, Anwar/E-9163-2015
OI Mehmood, Malik Hassan/0000-0002-9959-1458; Siddiqui,
   Bina/0000-0001-8160-0021; Gilani, Anwar/0000-0001-6477-2227
CR Ahmed T, 2014, PHYTOTHER RES, V28, P517, DOI 10.1002/ptr.5030
   Alappat L, 2010, NUTR REV, V68, P729, DOI 10.1111/j.1753-4887.2010.00341.x
   Ali BH, 2003, PHYTOTHER RES, V17, P299, DOI 10.1002/ptr.1309
   Amin F, 2013, LIPIDS HEALTH DIS, V12, DOI 10.1186/1476-511X-12-44
   Anand P, 2007, MOL PHARMACEUT, V4, P807, DOI 10.1021/mp700113r
   Di Verniero CA, 2008, J CARDIOVASC PHARM, V51, P532, DOI 10.1097/FJC.0b013e3181730306
   Anwar-ul-Hassan Gilani Anwar-ul-Hassan Gilani, 2004, Pakistan Journal of Biological Sciences, V7, P441, DOI 10.3923/pjbs.2004.441.451
   Aroda VR, 2008, J CLIN ENDOCR METAB, V93, P3259, DOI 10.1210/jc.2008-1091
   Barbosa CR, 2007, BRAZ J MED BIOL RES, V40, P323, DOI 10.1590/S0100-879X2007000300007
   Benhaddou-Andaloussi A, 2010, DIABETES OBES METAB, V12, P148, DOI 10.1111/j.1463-1326.2009.01131.x
   Benzie IFF W.-G.S., 2011, Turmeric, the golden spice: from traditional medicine to modern medicine, V2nd
   Chattopadhyay I, 2004, CURR SCI INDIA, V87, P44
   Chou TC, 2006, PHARMACOL REV, V58, P621, DOI 10.1124/pr.58.3.10
   de Moura RF, 2009, BRIT J NUTR, V101, P1178, DOI 10.1017/S0007114508066774
   Dewar AM, 2011, J INVEST DERMATOL, V131, P1754, DOI 10.1038/jid.2011.96
   Endemann DH, 2004, J AM SOC NEPHROL, V15, P1983, DOI 10.1097/01.ASN.0000132474.50966.DA
   FURCHGOTT RF, 1980, NATURE, V288, P373, DOI 10.1038/288373a0
   Gilani A. H., 2001, JPMA (Journal of the Pakistan Medical Association), V51, P115
   Gilani AH, 2005, LIFE SCI, V76, P3089, DOI 10.1016/j.lfs.2004.12.021
   Gilani AH, 2005, J ETHNOPHARMACOL, V100, P43, DOI 10.1016/j.jep.2005.06.001
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Grundy SM, 2004, ARTERIOSCL THROM VAS, V24, pE13, DOI 10.1161/01.ATV.0000111245.75752.C6
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jang EM, 2008, METABOLISM, V57, P1576, DOI 10.1016/j.metabol.2008.06.014
   Kanter M, 2004, ANAT REC PART A, V279A, P685, DOI 10.1002/ar.a.20056
   Katakam PV, 1998, AM J PHYSIOL, V275, P788
   Kunitomo M, 2008, J PHARMACOL SCI, V107, P128, DOI 10.1254/jphs.FP0072365
   Kuroda M, 2005, BIOL PHARM BULL, V28, P937, DOI 10.1248/bpb.28.937
   Le PM, 2004, J ETHNOPHARMACOL, V94, P251, DOI 10.1016/j.jep.2004.04.030
   Lee YC, 2006, LIFE SCI, V78, P1155, DOI 10.1016/j.lfs.2005.06.009
   Majithiya JB, 2005, J CARDIOVASC PHARM, V46, P697, DOI 10.1097/01.fjc.0000183720.85014.24
   Masoudi FA, 2005, CIRCULATION, V111, P583, DOI 10.1161/01.CIR.0000154542.13412.B1
   Ortlepp JR, 2002, EUR J PHARMACOL, V436, P145, DOI 10.1016/S0014-2999(01)01587-4
   Padiya R, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-53
   Rchid H, 2004, FUND CLIN PHARMACOL, V18, P525, DOI 10.1111/j.1472-8206.2004.00275.x
   Rodrigo E, 1997, J HYPERTENS, V15, P613, DOI 10.1097/00004872-199715060-00007
   Sanchez-Lozada LG, 2007, AM J PHYSIOL-RENAL, V292, pF423, DOI 10.1152/ajprenal.00124.2006
   Shehzad A, 2011, EUR J NUTR, V50, P151, DOI 10.1007/s00394-011-0188-1
   Singletary K., 2010, Nutrition Today, V45, P216
   Tagzirt M, 2014, AM J HYPERTENS, V27, P1096, DOI 10.1093/ajh/hpu021
   Tzeng TF, 2011, EVID-BASED COMPL ALT, V2011, DOI 10.1093/ecam/neq017
   Um MY, 2013, BASIC CLIN PHARMACOL, V113, P152, DOI 10.1111/bcpt.12076
   Van Vliet BN, 2000, J PHARMACOL TOXICOL, V44, P361, DOI 10.1016/S1056-8719(00)00126-X
   Verma S, 1996, AM J HYPERTENS, V9, P370, DOI 10.1016/0895-7061(95)00392-4
   Wagner H, 2009, PHYTOMEDICINE, V16, P97, DOI [10.1016/j.phymed.2008.12.018, 10.1016/j.fitote.2010.11.016]
   Weisberg SP, 2008, ENDOCRINOLOGY, V149, P3549, DOI 10.1210/en.2008-0262
   Weng JK, 2012, SCIENCE, V336, P1667, DOI 10.1126/science.1217411
   Woods V, 2012, FASEB J, V26
   Xi LA, 2011, HEPATOLOGY, V53, P127, DOI 10.1002/hep.24011
NR 49
TC 13
Z9 13
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0160-2446
EI 1533-4023
J9 J CARDIOVASC PHARM
JI J. Cardiovasc. Pharmacol.
PD FEB
PY 2015
VL 65
IS 2
BP 176
EP 183
PG 8
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA CB0KE
UT WOS:000349313800012
PM 25384193
DA 2025-06-11
ER

PT J
AU Sundaresan, A
   Harini, R
   Pugalendi, KV
AF Sundaresan, Arjunan
   Harini, Ranganathan
   Pugalendi, Kodukkur Viswanathan
TI Ursolic acid and rosiglitazone combination alleviates metabolic syndrome
   in high fat diet fed C57BL/6J mice
SO GENERAL PHYSIOLOGY AND BIOPHYSICS
LA English
DT Article
DE Metabolic Syndrome; High fat diet; Ursolic acid; Rosiglitazone; C57BL/6J
   mice
ID TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE; GLUCOSE-HOMEOSTASIS;
   OXIDATIVE STRESS; OLEANOLIC ACID; OBESITY; RATS; HYPERTENSION; WEIGHT;
   LIVER
AB The aim of this study was to examine the combined effect of ursolic acid (UA) and rosiglitazone (RSG) on metabolic syndrome in C57BL/6J mice. Upon feeding high fat diet (HFD) C57BL/6J mice developed obesity, insulin resistance, dyslipidemia and hypertension. The male mice were randomly divided into six groups, and fed normal diet, normal diet plus UA and RSG, HFD alone, HFD plus UA, HFD plus RSG, and HFD plus UA and RSG, respectively. HFD fed mice showed increase in body weight, elevated plasma glucose and insulin. Activities of gluconeogenic enzymes such as glucose 6-phosphatase, fructose 1,6-bisphosphatase increased while the activity of glycolytic enzyme, glucokinase, decreased in the liver along with glycogen content. Total cholesterol, triglyceride, low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol and free fatty acid levels significantly increased in the plasma, whereas high-density lipoprotein cholesterol significantly decreased in high fat diet fed mice. In addition, both systolic and diastolic blood pressure was increased significantly. Combined treatment with UA and RSG improved the above parameters towards normality and pronounced more responses than UA or RSG lone treatment. The inclusion of UA in treatment with RSG may reduce the body weight gain, one of adverse side effect associated with the RSG-therapy.
C1 [Sundaresan, Arjunan; Harini, Ranganathan; Pugalendi, Kodukkur Viswanathan] Annamalai Univ, Dept Biochem & Biotechnol, Fac Sci, Annamalainagar 608002, Tamil Nadu, India.
C3 Annamalai University
RP Pugalendi, KV (corresponding author), Annamalai Univ, Dept Biochem & Biotechnol, Fac Sci, Annamalainagar 608002, Tamil Nadu, India.
EM pugale@sify.com
OI Arjunan, Sundaresan/0000-0001-9633-8134
FU Indian Council of Medical Research, New Delhi
FX The financial support to Arjunan Sundaresan as Senior Research
   Fellowship from Indian Council of Medical Research, New Delhi, is
   gratefully acknowledged.
CR Arner P, 2003, TRENDS ENDOCRIN MET, V14, P137, DOI 10.1016/S1043-2760(03)00024-9
   BALANEHRU S, 1991, BIOCHEM INT, V24, P981
   Balfour JAB, 1999, DRUGS, V57, P921
   Bancroft John D., 2002, Theory & practice of histological technique, V5th
   BRANDSTRUP N, 1957, J GERONTOL, V12, P166, DOI 10.1093/geronj/12.2.166
   BURGI W, 1988, CLIN BIOCHEM, V21, P311, DOI 10.1016/S0009-9120(88)80087-0
   Choi JS, 2007, BRIT J NUTR, V98, P264, DOI 10.1017/S000711450770497X
   Cong WN, 2008, LIFE SCI, V82, P983, DOI 10.1016/j.lfs.2008.01.022
   DeFronzo RA, 2004, MED CLIN N AM, V88, P787, DOI 10.1016/j.mcna.2004.04.013
   Diamant M, 2003, DRUGS, V63, P1373, DOI 10.2165/00003495-200363130-00004
   Ding SY, 2005, ACTA PHARMACOL SIN, V26, P575, DOI 10.1111/j.1745-7254.2005.00090.x
   Drabkin DL, 1932, J BIOL CHEM, V98, P719
   Evans JL, 2003, DIABETES, V52, P1, DOI 10.2337/diabetes.52.1.1
   FALHOLT K, 1973, CLIN CHIM ACTA, V46, P105, DOI 10.1016/0009-8981(73)90016-8
   Feldstein AE, 2003, J HEPATOL, V39, P978, DOI 10.1016/S0168-8278(03)00460-4
   Fiske CH, 1925, J BIOL CHEM, V66, P375
   Foster JD, 1997, P SOC EXP BIOL MED, V215, P314
   Friedewald W, 1972, CLIN CHEM, V18, P449
   GANCEDO JM, 1971, ARCH MIKROBIOL, V76, P132, DOI 10.1007/BF00411787
   GINSBERG H, 1975, J CLIN INVEST, V55, P454, DOI 10.1172/JCI107951
   Grundy SM, 1999, AM J CARDIOL, V83, p25F
   Guignot L, 1999, AM J PHYSIOL-ENDOC M, V277, pE984, DOI 10.1152/ajpendo.1999.277.6.E984
   Jayaprakasam B, 2006, J AGR FOOD CHEM, V54, P243, DOI 10.1021/jf0520342
   KOIDE H, 1959, CLIN CHIM ACTA, V4, P554
   Kolovou GD, 2005, POSTGRAD MED J, V81, P358, DOI 10.1136/pgmj.2004.025601
   Lim S, 2009, METABOLISM, V58, P8, DOI 10.1016/j.metabol.2008.07.027
   Liu J, 1995, J ETHNOPHARMACOL, V49, P57, DOI 10.1016/0378-8741(95)90032-2
   Lowell BB, 1999, CELL, V99, P239, DOI 10.1016/S0092-8674(00)81654-2
   Masoudi FA, 2003, JAMA-J AM MED ASSOC, V290, P81, DOI 10.1001/jama.290.1.81
   Monnier L., 1995, Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales, V189, P919
   Morales M.A., 1973, NEUROSPORA NEWSL, V20, P24, DOI 10.4148/1941-4765.1830
   NAYAK SS, 1981, CLIN CHIM ACTA, V109, P267
   Petersen KF, 2006, AM J MED, V119, p10S, DOI 10.1016/j.amjmed.2006.01.009
   POLONSKY KS, 1988, J CLIN INVEST, V81, P435, DOI 10.1172/JCI113338
   Postic C, 1999, J BIOL CHEM, V274, P305, DOI 10.1074/jbc.274.1.305
   Proietto J, 2005, HEPATOL RES, V33, P87, DOI 10.1016/j.hepres.2005.09.010
   Riemens SC, 2000, DIABETOLOGIA, V43, P416, DOI 10.1007/s001250051324
   Saravanan R, 2006, PHARMACOL REP, V58, P41
   Sasaki T., 1972, Rinshbo Kagaku, V1, P346
   Scheen AJ, 2005, DRUG SAFETY, V28, P601, DOI 10.2165/00002018-200528070-00004
   Schrauwen-Hinderling VB, 2005, OBES RES, V13, P2088, DOI 10.1038/oby.2005.259
   Semenkovich CF, 2006, J CLIN INVEST, V116, P1813, DOI 10.1172/JCI29024
   Senthil S, 2007, INT J CARDIOL, V119, P131, DOI 10.1016/j.ijcard.2006.07.108
   SHON KH, 1995, CANCER LETT, V94, P213, DOI 10.1016/0304-3835(95)03856-R
   Somova LO, 2003, PHYTOMEDICINE, V10, P115, DOI 10.1078/094471103321659807
   Sowers JR, 2004, AM J PHYSIOL-HEART C, V286, pH1597, DOI 10.1152/ajpheart.00026.2004
   STEINBRECHER UP, 1984, DIABETES, V33, P130, DOI 10.2337/diabetes.33.2.130
   SURWIT RS, 1988, DIABETES, V37, P1163, DOI 10.2337/diabetes.37.9.1163
   TAHARA Y, 1995, DIABETES CARE, V18, P440, DOI 10.2337/diacare.18.4.440
   TASKINEN MR, 1986, DIABETES, V35, P1268, DOI 10.2337/diabetes.35.11.1268
   VidalPuig AJ, 1997, J CLIN INVEST, V99, P2416, DOI 10.1172/JCI119424
   Wu LY, 2004, AM J HYPERTENS, V17, P749, DOI 10.1016/j.amjhyper.2004.04.010
   Yip J, 1998, J CLIN ENDOCR METAB, V83, P2773, DOI 10.1210/jc.83.8.2773
   Zhang W, 2006, BBA-GEN SUBJECTS, V1760, P1505, DOI 10.1016/j.bbagen.2006.05.009
NR 54
TC 31
Z9 34
U1 0
U2 16
PU GENERAL PHYSIOL AND BIOPHYSICS
PI BRATISLAVA
PA INST OF MOLEC PHYSIOL GENETICS SLOVAK ACAD OF SCI VLARSKA 5, 83334
   BRATISLAVA, SLOVAKIA
SN 0231-5882
EI 1338-4325
J9 GEN PHYSIOL BIOPHYS
JI Gen. Physiol. Biophys.
PD SEP
PY 2012
VL 31
IS 3
BP 323
EP 333
DI 10.4149/gpb_2012_037
PG 11
WC Biochemistry & Molecular Biology; Biophysics; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Physiology
GA 010KP
UT WOS:000309093600010
PM 23047945
OA Bronze
DA 2025-06-11
ER

PT J
AU Naimipoor, N
   Bagheri-Hosseinabadi, Z
   Hajizadeh, MR
   Abbasifard, M
   Mirzaei, MR
   Anari, AG
   Mohammad-Sadeghipour, M
   Mahmoodi, M
AF Naimipoor, Neda
   Bagheri-Hosseinabadi, Zahra
   Hajizadeh, Mohammad Reza
   Abbasifard, Mitra
   Mirzaei, Mohammad Reza
   Anari, Akram Ghadiri
   Mohammad-Sadeghipour, Maryam
   Mahmoodi, Mehdi
TI Promising effects of Persian shallot extract on the serum markers and
   blood pressure of patients with metabolic syndrome: a double-blinded
   randomized controlled trial
SO JOURNAL OF TRADITIONAL CHINESE MEDICINE
LA English
DT Article
DE shallots; medicine; Persian; metabolic syndrome; antioxidants
ID OXIDATIVE STRESS; ALLICIN; DISEASE; OXIDANT
AB OBJECTIVE: To evaluate the effect of Persian shallot extract on the serum markers and blood pressure of patients with metabolic syndrome (MetS). METHODS: Fifty patients with MetS diagnosis were randomly assigned to the intervention (Persian shallot extract) and the control (placebo) group. Both groups received treatment for three months. Before the study and at the end of the study, 5 mL peripheral blood was taken from each patient. The measured factors included total antioxidant capacity (TAC), superoxide dismutase enzyme (SOD), malondialdehyde, oxidized low-density lipoprotein (Ox-LDL), apolipoprotein H (Apo-H), fasting blood glucose (FBS), total cholesterol, triglycerides, high-density lipoprotein (HDL), LDL, and systolic and diastolic blood pressure. RESULTS: At baseline, the evaluated parameters were not significantly different between the intervention and control groups. At the end of the study, the mean serum levels of malondialdehyde and ox-LDL were significantly lower in the intervention group. The mean FBS, cholesterol, triglycerides, and LDL were significantly lower in the intervention group. The mean TAC and HDL were significantly higher in the intervention group (P < 0.05). Moreover, the intervention group significantly reduced systolic and diastolic blood pressure. No other significant association was observed. CONCLUSION: Persian shallot extract has several beneficial effects in MetS patients, including optimizing oxidative balance, reducing blood pressure, fasting blood sugar, and blood lipid profile
C1 [Naimipoor, Neda; Bagheri-Hosseinabadi, Zahra; Hajizadeh, Mohammad Reza] Rafsanjan Univ Med Sci, Sch Med, Dept Clin Biochem, Rafsanjan 77181759, Iran.
   [Abbasifard, Mitra] Rafsanjan Univ Med Sci, Ali Ibn Abi Talib Hosp, Sch Med, Dept Internal Med, Rafsanjan 7717937555, Iran.
   [Mirzaei, Mohammad Reza] Rafsanjan Univ Med Sci, Res Inst Basic Med Sci, Mol Med Res Ctr, Rafsanjan 7718175911, Iran.
   [Anari, Akram Ghadiri] Shahid Sadoughi Univ Med Sci, Diabet Res Ctr, Yazd 8917693571, Iran.
   [Mohammad-Sadeghipour, Maryam; Mahmoodi, Mehdi] Kerman Univ Med Sci, Afzalipour Med Sch, Dept Dermatol, Kerman 7616914115, Iran.
   [Mohammad-Sadeghipour, Maryam; Mahmoodi, Mehdi] Kerman Univ Med Sci, Inst Neuropharmacol, Physiol Res Ctr, Kerman 7619813159, Iran.
C3 Shahid Sadoughi University of Medical Sciences; Kerman University of
   Medical Sciences; Kerman University of Medical Sciences
RP Mahmoodi, M (corresponding author), Kerman Univ Med Sci, Afzalipour Med Sch, Dept Dermatol, Kerman 7616914115, Iran.
EM me.mahmoodi@kmu.ac.ir
RI bagheri, zahra/O-5273-2018; Mohammad-Sadeghipour, Maryam/AAX-6052-2021;
   Abbasifard, mitra/I-1595-2017; Mirzaei, Mohammad Reza/C-8947-2017;
   Ghadiri-Anari, Akram/F-6290-2017
CR Abdelrahman M, 2020, MOLECULES, V25, DOI 10.3390/molecules25225300
   Alemany M, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25042251
   Bagherifard A, 2020, CLIN NUTR ESPEN, V38, P118, DOI 10.1016/j.clnesp.2020.05.019
   Barkat MA, 2021, COMB CHEM HIGH T SCR, V24, P1573, DOI 10.2174/1386207323999201110192942
   Cheng BJ, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/3956504
   Cui TW, 2020, BIOMED PHARMACOTHER, V128, DOI 10.1016/j.biopha.2020.110240
   Dwyer AA, 2018, FRONT HORM RES, V49, P156, DOI 10.1159/000485998
   Dziegielewska-Gesiak S, 2021, CLIN INTERV AGING, V16, P1057, DOI 10.2147/CIA.S306982
   Eftekhari MH, 2014, ARYA ATHEROSCLER, V10, P82
   Rubio-Ruiz ME, 2019, MOLECULES, V24, DOI 10.3390/molecules24071297
   Francisqueti FV, 2017, REV ASSOC MED BRAS, V63, P85
   Trejo EMAG, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18091980
   Ghafarifarsani H, 2022, AQUACULTURE, V555, DOI 10.1016/j.aquaculture.2022.738162
   Ghafarifarsani H, 2021, ANIMALS-BASEL, V11, DOI 10.3390/ani11102995
   De Greef D, 2021, SEMIN CANCER BIOL, V73, P219, DOI 10.1016/j.semcancer.2020.11.020
   Hao Y, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.711060
   He CY, 2019, FOODS, V8, DOI 10.3390/foods8090355
   Heshmat-Ghahdarijani K, 2022, COMPLEMENT THER CLIN, V49, DOI 10.1016/j.ctcp.2022.101654
   Hess PL, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.117.006103
   Hosseini FS, 2017, CYTOTECHNOLOGY, V69, P551, DOI 10.1007/s10616-017-0093-4
   Altun HK, 2021, PUBLIC HEALTH NUTR, V24, P861, DOI 10.1017/S1368980020005297
   Karthikkumar Venkatachalam, 2020, Research Journal of Pharmacy and Technology, V13, P1009, DOI 10.5958/0974-360X.2020.00187.0
   Kaur A, 2023, J DIABETES METAB DIS, V22, P547, DOI 10.1007/s40200-022-01176-z
   Khaleghi S, 2016, JRPS, V5, P33
   Kim D, 2018, CLIN LIVER DIS, V22, P133, DOI 10.1016/j.cld.2017.08.010
   Kothari D, 2019, ANIMALS-BASEL, V9, DOI 10.3390/ani9121032
   Libowitz MR, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.623681
   Liu DS, 2017, EXP THER MED, V14, P1722, DOI 10.3892/etm.2017.4698
   Lu J, 2017, BIOMED PHARMACOTHER, V96, P1411, DOI 10.1016/j.biopha.2017.10.125
   Ma LN, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/3207973
   Mehdi M, 2013, PAK J PHARM SCI, V26, P397
   Mehriardestani M, 2017, BIOMED PHARMACOTHER, V88, P885, DOI 10.1016/j.biopha.2017.01.149
   Marón FJM, 2020, LIFE SCI, V249, DOI 10.1016/j.lfs.2020.117513
   Monserrat-Mesquida M, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9030236
   Nazeri Z, 2021, AVICENNA J PHYTOMEDI, V11, P473, DOI [10.22038/ajp.2021.17834, 10.22038/AJP.2021.17834]
   Nishimura M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010091
   Omidifar N, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/7457504
   Panahandeh J., 2016, Journal of Medicinal Plants and By-Products, V5, P217
   Pasquali R, 2018, FRONT HORM RES, V49, P114, DOI 10.1159/000485995
   Patti AM, 2018, ARCH MED SCI, V14, P422, DOI 10.5114/aoms.2017.68717
   Rahimi-Madiseh M, 2017, BIOMED PHARMACOTHER, V86, P363, DOI 10.1016/j.biopha.2016.12.028
   Russo B, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20092061
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Salehi B, 2019, TRENDS FOOD SCI TECH, V86, P502, DOI 10.1016/j.tifs.2019.03.003
   Sánchez-Gloria JL, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23169082
   Satvati SAR, 2017, Int J Enteric Pathog, V5, P63, DOI 10.15171/ijep.2017
   Shi XE, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122909
   Sun WenLi Sun WenLi, 2019, Journal of Medicinal Plants Research, V13, P452
   Wang JY, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/7255413
   Xu YXZ, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/9182595
   Yen FS, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/2057333
   Zhang SY, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22116110
NR 52
TC 0
Z9 0
U1 4
U2 4
PU JOURNAL TRADITIONAL CHINESE MED
PI BEIJING
PA 16 NANXIAOJIE, DONGZHIMEN NEI, BEIJING, 100700, PEOPLES R CHINA
SN 0255-2922
EI 1577-7014
J9 J TRADIT CHIN MED
JI J. Tradit. Chin. Med.
PY 2025
VL 45
IS 1
BP 100
EP 106
DI 10.19852/j.cnki.jtcm.2025.01.008
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA X2I9F
UT WOS:001423661500001
PM 39957163
DA 2025-06-11
ER

PT J
AU Choromanska, B
   Mysliwiec, P
   Luba, M
   Wojskowicz, P
   Mysliwiec, H
   Choromanska, K
   Zendzian-Piotrowska, M
   Dadan, J
   Zalewska, A
   Maciejczyk, M
AF Choromanska, Barbara
   Mysliwiec, Piotr
   Luba, Magdalena
   Wojskowicz, Piotr
   Mysliwiec, Hanna
   Choromanska, Katarzyna
   Zendzian-Piotrowska, Malgorzata
   Dadan, Jacek
   Zalewska, Anna
   Maciejczyk, Mateusz
TI Impact of Weight Loss on the Total Antioxidant/Oxidant Potential in
   Patients with Morbid Obesity-A Longitudinal Study
SO ANTIOXIDANTS
LA English
DT Article
DE obesity; bariatric surgery; laparoscopic sleeve gastrectomy;
   antioxidants; total antioxidant activity
ID LAPAROSCOPIC SLEEVE GASTRECTOMY; Y GASTRIC BYPASS; OXIDATIVE STRESS;
   URIC-ACID; INSULIN-RESISTANCE; CAPACITY; ASSOCIATION; RADICALS
AB The assessment of total antioxidant activity seems to have a higher diagnostic value than the evaluation of individual antioxidants separately. Therefore, this is the first study to assess the total antioxidant/oxidant status in morbidly obese patients undergoing bariatric surgery. The study involved 60 patients with Class 3 obesity (BMI > 40 kg/m(2)) divided into two equal subgroups: morbidly obese patients without and with metabolic syndrome. The analyses were performed in plasma samples collected before surgery as well as 1, 3, 6, and 12 months after a laparoscopic sleeve gastrectomy. Total antioxidant capacity (TAC), ferric-reducing antioxidant power (FRAP), DPPH (2,2 ' -diphenyl-1-picrylhydrazyl) radical assay, and total oxidant status (TOS) were significantly higher before surgery (as compared to the healthy controls, n = 60) and generally decreased after bariatric treatment. Interestingly, all assessed biomarkers correlated positively with uric acid content. However, the total antioxidant/oxidant potential did not differ between obese patients without metabolic syndrome and those with both obesity and metabolic syndrome. Only DPPH differentiated the two subgroups (p < 0.0001; AUC 0.8) with 73% sensitivity and 77% specificity. Plasma TAC correlated positively with body mass index, waist-hip ratio, serum insulin, and uric acid. Therefore, TAC seems to be the best biomarker to assess the antioxidant status of obese patients.
C1 [Choromanska, Barbara; Mysliwiec, Piotr; Luba, Magdalena; Wojskowicz, Piotr; Dadan, Jacek] Med Univ Bialystok, Dept Gen & Endocrine Surg 1, 24a M Sklodowskiej Curie St, PL-15276 Bialystok, Poland.
   [Mysliwiec, Hanna] Med Univ Bialystok, Dept Dermatol & Venereol, 14 Zurawia St, PL-15540 Bialystok, Poland.
   [Choromanska, Katarzyna] Med Univ Gdansk, Dept Oral Surg, 7 Debinki St, PL-80211 Gdansk, Poland.
   [Zendzian-Piotrowska, Malgorzata; Maciejczyk, Mateusz] Med Univ Bialystok, Dept Hyg Epidemiol & Ergon, 2c Mickiewicza St, PL-15233 Bialystok, Poland.
   [Zalewska, Anna] Med Univ Bialystok, Expt Dent Lab, 24a M Sklodowskiej Curie St, PL-15274 Bialystok, Poland.
C3 Medical University of Bialystok; Medical University of Bialystok;
   Fahrenheit Universities; Medical University Gdansk; Medical University
   of Bialystok; Medical University of Bialystok
RP Choromanska, B (corresponding author), Med Univ Bialystok, Dept Gen & Endocrine Surg 1, 24a M Sklodowskiej Curie St, PL-15276 Bialystok, Poland.; Maciejczyk, M (corresponding author), Med Univ Bialystok, Dept Hyg Epidemiol & Ergon, 2c Mickiewicza St, PL-15233 Bialystok, Poland.
EM barbara.choromanska@umb.edu.pl; piotr.mysliwiec@umb.edu.pl;
   ananau@wp.pl; pwojsk@wp.pl; hanna.mysliwiec@umb.edu.pl;
   kasia24_89@o2.pl; malgorzata.zendzian-piotrowska@umb.edu.pl;
   jacdad@poczta.onet.pl; anna.zalewska1@umb.edu.pl;
   mateusz.maciejczyk@umb.edu.pl
RI Zalewska, Anna/AAG-9484-2019; Myśliwiec, Piotr/T-4220-2018; Myśliwiec,
   Hanna/S-6326-2018; Żendzian-Piotrowska, Małgorzata/G-4481-2011;
   Maciejczyk, Mateusz/R-6568-2018; Zendzian-Piotrowska,
   Malgorzata/S-6354-2018
OI Maciejczyk, Mateusz/0000-0001-5609-3187; Dadan,
   Jacek/0000-0002-0691-9785; Zendzian-Piotrowska,
   Malgorzata/0000-0002-4350-0369
FU Medical University of Bialystok, Poland [SUB/1/DN/20/002/1209,
   SUB/1/DN/20/002/3330, SUB/1/DN/19/002/1140]
FX This work was supported by grants from the Medical University of
   Bialystok, Poland (grant numbers: SUB/1/DN/20/002/1209;
   SUB/1/DN/20/002/3330; SUB/1/DN/19/002/1140).
CR Adil MT, 2018, BRIT J SURG, V105, P1107, DOI 10.1002/bjs.10880
   Aghamohammadi V, 2019, DIABETES METAB SYND, V13, P2763, DOI 10.1016/j.dsx.2019.07.030
   Andò S, 2019, CANCERS, V11, DOI 10.3390/cancers11010062
   Angrisani L, 2015, OBES SURG, V25, P1822, DOI 10.1007/s11695-015-1657-z
   Arnao MB, 2000, TRENDS FOOD SCI TECH, V11, P419, DOI 10.1016/S0924-2244(01)00027-9
   Benzie IFF, 1996, ANAL BIOCHEM, V239, P70, DOI 10.1006/abio.1996.0292
   Chaudhary K, 2013, CARDIORENAL MED, V3, P208, DOI 10.1159/000355405
   Choromanska B, 2020, J CLIN MED, V9, DOI 10.3390/jcm9040976
   Choromanska B, 2019, OBESITY, V27, P444, DOI 10.1002/oby.22405
   Cornejo-Pareja I, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00626
   Daigle CR, 2018, SURG OBES RELAT DIS, V14, P652, DOI 10.1016/j.soard.2018.01.008
   Erel O, 2004, CLIN BIOCHEM, V37, P277, DOI 10.1016/j.clinbiochem.2003.11.015
   Erel O, 2005, CLIN BIOCHEM, V38, P1103, DOI 10.1016/j.clinbiochem.2005.08.008
   Fejfer K, 2017, BIOMED RES INT, V2017, DOI 10.1155/2017/4923769
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Goutzourelas N, 2018, EXP THER MED, V16, P635, DOI 10.3892/etm.2018.6204
   Grzegorczyk EA, 2018, NUTR DIABETES, V8, DOI 10.1038/s41387-017-0013-x
   International Diabetes Federation, 2006, IDF CONS WORLDW DEF
   Janaszewska A, 2002, SCAND J CLIN LAB INV, V62, P231, DOI 10.1080/003655102317475498
   Klimiuk A, 2020, J CLIN MED, V9, DOI 10.3390/jcm9030769
   Klimiuk A, 2019, J CLIN MED, V8, DOI 10.3390/jcm8060840
   Knas M, 2016, J ORAL PATHOL MED, V45, P455, DOI 10.1111/jop.12383
   Kusano C., 2008, J of Cell and Mol Biol, V7, P1
   Li S, 2015, INT J MOL SCI, V16, P26087, DOI 10.3390/ijms161125942
   Lushchak VI, 2014, CHEM-BIOL INTERACT, V224, P164, DOI 10.1016/j.cbi.2014.10.016
   Maciejczyk M, 2020, J CLIN MED, V9, DOI 10.3390/jcm9030837
   Maciejczyk M, 2020, J CLIN MED, V9, DOI 10.3390/jcm9020497
   Maciejczyk M, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/4393460
   Maciejczyk M, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.02322
   Maciejczyk M, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8090409
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Molnár D, 2004, INT J OBESITY, V28, P1197, DOI 10.1038/sj.ijo.0802719
   Murri M, 2010, OBES SURG, V20, P363, DOI 10.1007/s11695-009-0021-6
   Peluso Ilaria, 2016, Patholog Res Int, V2016, P5480267, DOI 10.1155/2016/5480267
   Peterli R, 2018, JAMA-J AM MED ASSOC, V319, P255, DOI 10.1001/jama.2017.20897
   Rizzo MR, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21062010
   Salminen P, 2018, JAMA-J AM MED ASSOC, V319, P241, DOI 10.1001/jama.2017.20313
   Sánchez-Moreno C, 2002, FOOD SCI TECHNOL INT, V8, P121, DOI [10.1177/1082013202008003770, 10.1106/108201302026770]
   Sautin YY, 2008, NUCLEOS NUCLEOT NUCL, V27, P608, DOI 10.1080/15257770802138558
   Schmatz R, 2017, CLIN CHIM ACTA, V465, P72, DOI 10.1016/j.cca.2016.12.012
   Sfar S, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-18
   Sharma RS, 2018, CELL MOL GASTROENTER, V5, P367, DOI 10.1016/j.jcmgh.2017.11.016
   Skalicky J, 2008, CLIN CHEM LAB MED, V46, P499, DOI 10.1515/CCLM.2008.096
   Skutnik-Radziszewska A, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/9086024
   Sudlow A, 2020, ENDOCR CONNECT, V9, pR28, DOI 10.1530/EC-19-0467
   Swiderska M, 2019, FREE RADICAL RES, V53, P841, DOI 10.1080/10715762.2019.1635691
   van der Schaft N, 2019, EUR J EPIDEMIOL, V34, P853, DOI 10.1007/s10654-019-00548-9
   Vlassara H, 2016, DIABETOLOGIA, V59, P2181, DOI 10.1007/s00125-016-4053-x
   Wang HG, 2014, IRAN J PUBLIC HEALTH, V43, P1503
   Wing R, 2013, NEW ENGL J MED, V369, P145, DOI 10.1056/NEJMoa1212914
   Yazici D, 2017, ADV EXP MED BIOL, V960, P277, DOI 10.1007/978-3-319-48382-5_12
   Zalewska A, 2020, J CLIN MED, V9, DOI 10.3390/jcm9020548
   Zinczuk J, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9100637
NR 53
TC 23
Z9 23
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAY
PY 2020
VL 9
IS 5
AR 376
DI 10.3390/antiox9050376
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA LW6WJ
UT WOS:000539284200019
PM 32369921
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Paczkowska-Abdulsalam, M
   Niemira, M
   Bielska, A
   Szalkowska, A
   Raczkowska, BA
   Junttila, S
   Gyenesei, A
   Adamska-Patruno, E
   Maliszewska, K
   Citko, A
   Szczerbinski, L
   Kretowski, A
AF Paczkowska-Abdulsalam, Magdalena
   Niemira, Magdalena
   Bielska, Agnieszka
   Szalkowska, Anna
   Raczkowska, Beata Anna
   Junttila, Sini
   Gyenesei, Attila
   Adamska-Patruno, Edyta
   Maliszewska, Katarzyna
   Citko, Anna
   Szczerbinski, Lukasz
   Kretowski, Adam
TI Evaluation of Transcriptomic Regulations behind Metabolic Syndrome in
   Obese and Lean Subjects
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE transcriptomics; obesity; obesity phenotypes; metabolic syndrome;
   cardiovascular disease
ID PERIPHERAL-BLOOD TRANSCRIPTOME; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   MAMMALIAN TARGET; INFLAMMATION; EXPRESSION; DISEASE; IMPACT; CELLS;
   LINKS
AB Multiple mechanisms have been suggested to confer to the pathophysiology of metabolic syndrome (MetS), however despite great interest from the scientific community, the exact contribution of each of MetS risk factors still remains unclear. The present study aimed to investigate molecular signatures in peripheral blood of individuals affected by MetS and different degrees of obesity. Metabolic health of 1204 individuals from 1000PLUS cohort was assessed, and 32 subjects were recruited to four study groups: MetS lean, MetS obese, "healthy obese", and healthy lean. Whole-blood transcriptome next generation sequencing with functional data analysis were carried out. MetS obese and MetS lean study participants showed the upregulation of genes involved in inflammation and coagulation processes: granulocyte adhesion and diapedesis (p < 0.0001, p = 0.0063), prothrombin activation pathway (p = 0.0032, p = 0.0091), coagulation system (p = 0.0010, p = 0.0155). The results for "healthy obese" indicate enrichment in molecules associated with protein synthesis (p < 0.0001), mitochondrial dysfunction (p < 0.0001), and oxidative phosphorylation (p < 0.0001). Our results suggest that MetS is related to the state of inflammation and vascular system changes independent of excess body weight. Furthermore, "healthy obese", despite not fulfilling the criteria for MetS diagnosis, seems to display an intermediate state with a lower degree of metabolic abnormalities, before they proceed to a full blown MetS.
C1 [Paczkowska-Abdulsalam, Magdalena; Niemira, Magdalena; Bielska, Agnieszka; Szalkowska, Anna; Adamska-Patruno, Edyta; Citko, Anna; Szczerbinski, Lukasz; Kretowski, Adam] Med Univ Bialystok, Clin Res Ctr, M Sklodowskiej Curie 24A, PL-15276 Bialystok, Poland.
   [Raczkowska, Beata Anna; Maliszewska, Katarzyna; Kretowski, Adam] Med Univ Bialystok, Dept Endocrinol Diabetol & Internal Med, M Sklodowskiej Curie 24A, PL-15276 Bialystok, Poland.
   [Junttila, Sini; Gyenesei, Attila] Vienna Bioctr Core Facil, Dr Bohr Gasse 3, A-1030 Vienna, Austria.
C3 Medical University of Bialystok; Medical University of Bialystok
RP Paczkowska-Abdulsalam, M (corresponding author), Med Univ Bialystok, Clin Res Ctr, M Sklodowskiej Curie 24A, PL-15276 Bialystok, Poland.
EM magdalena.paczkowska@umb.edu.pl; Magdalena.niemira@umb.edu.pl;
   Agnieszka.bielska@umb.edu.pl; Anna.szalkowska@umb.edu.pl;
   raczkowskabeataanna@gmail.com; simaju@utu.fi; gyenesei.attila@pte.hu;
   edyta.adamska@umb.edu.pl; maliszewska.k@gmail.com;
   Anna.citko@umb.edu.pl; Lukasz.szczerbinski@umb.edu.pl;
   adamkretowski@wp.pl
RI Paczkowska-Abdulsalam, Magdalena/ABD-1828-2020; Szczerbinski,
   Lukasz/U-9000-2018; Niemira, Magdalena/T-8076-2019; Maliszewska,
   Katarzyna/U-8153-2018; Adamska-Patruno, Edyta/L-5788-2018; Kretowski,
   Adam/U-6299-2018; Niemira, Magdalena/T-9091-2018
OI Adamska-Patruno, Edyta/0000-0002-8805-0744; Kretowski,
   Adam/0000-0002-4522-4978; Niemira, Magdalena/0000-0002-0701-4961;
   Ostrowska, Agnieszka/0000-0002-2619-4494; Szczerbinski,
   Lukasz/0000-0002-6201-0605; Zeller, Anna/0000-0002-5446-544X;
   Paczkowska-Abdulsalam, Magdalena/0000-0001-7158-6983
FU Ministry of Science and Higher Education in Poland
FX This work was supported by funds from the Ministry of Science and Higher
   Education in Poland (National Leading Research Centre).
CR Adamska E, 2018, DIABETES METAB, V44, P379, DOI 10.1016/j.diabet.2017.05.001
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alessi MC, 2008, THROMB HAEMOSTASIS, V99, P995, DOI 10.1160/TH07-11-0682
   Anders S, 2015, BIOINFORMATICS, V31, P166, DOI 10.1093/bioinformatics/btu638
   Bartolome A, 2014, VITAM HORM, V95, P425, DOI 10.1016/B978-0-12-800174-5.00017-X
   Beineke P, 2012, BMC MED GENOMICS, V5, DOI 10.1186/1755-8794-5-58
   Briaud I, 2005, J BIOL CHEM, V280, P2282, DOI 10.1074/jbc.M412179200
   Buchwald H, 2004, JAMA-J AM MED ASSOC, V292, P1724, DOI 10.1001/jama.292.14.1724
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Nguyen CB, 2017, J TRANSL MED, V15, DOI 10.1186/s12967-017-1201-0
   Debey S, 2004, PHARMACOGENOMICS J, V4, P193, DOI 10.1038/sj.tpj.6500240
   DEFRONZO RA, 1991, DIABETES CARE, V14, P173, DOI 10.2337/diacare.14.3.173
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Eising E, 2017, SCI REP-UK, V7, DOI 10.1038/srep40218
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Ghosh S, 2010, BMC MED GENOMICS, V3, DOI 10.1186/1755-8794-3-56
   Grundy SM, 2015, EUR J CLIN INVEST, V45, P1209, DOI 10.1111/eci.12519
   Heng YJJ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0096901
   Ikramuddin S, 2011, BRIT J SURG, V98, P1339, DOI 10.1002/bjs.7652
   Jia GH, 2014, AM J PHYSIOL-REG I, V307, pR1198, DOI 10.1152/ajpregu.00262.2014
   Johnson AR, 2012, IMMUNOL REV, V249, P218, DOI 10.1111/j.1600-065X.2012.01151.x
   Kadenbach B, 2012, ADV EXP MED BIOL, V748, P1, DOI 10.1007/978-1-4614-3573-0_1
   Kraja AT, 2007, NUTR METAB, V4, DOI 10.1186/1743-7075-4-28
   Kretowski A, 2015, GENES NUTR, V10, DOI 10.1007/s12263-015-0454-6
   Krjutskov K, 2016, SCI REP-UK, V6, DOI 10.1038/srep31584
   Laplante M, 2012, CELL, V149, P274, DOI 10.1016/j.cell.2012.03.017
   Laugerette F, 2014, MOL NUTR FOOD RES, V58, P1513, DOI 10.1002/mnfr.201400044
   Liew CC, 2006, J LAB CLIN MED, V147, P126, DOI 10.1016/j.lab.2005.10.005
   Lowell BB, 2005, SCIENCE, V307, P384, DOI 10.1126/science.1104343
   Lumeng CN, 2011, J CLIN INVEST, V121, P2111, DOI 10.1172/JCI57132
   Maliszewska K, 2019, NUTRIENTS, V11, DOI 10.3390/nu11040834
   Manoel-Caetano FS, 2012, GENE, V511, P151, DOI 10.1016/j.gene.2012.09.090
   Mohr S, 2007, TRENDS MOL MED, V13, P422, DOI 10.1016/j.molmed.2007.08.003
   Moreno-Viedma V, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-016-0441-2
   Odrowqz-Sypniewska G, 2007, ADV MED SCI-POLAND, V52, P246
   Ozean U, 2008, MOL CELL, V29, P541, DOI [10.1016/j.moicel.2007.12.023, 10.1016/j.molcel.2007.12.023]
   Poelkens F, 2013, EXP PHYSIOL, V98, P1485, DOI 10.1113/expphysiol.2013.072710
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Shin H, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0091041
   Sutherland JP, 2004, METAB SYNDR RELAT D, V2, P82, DOI 10.1089/met.2004.2.82
   Tyner C, 2017, NUCLEIC ACIDS RES, V45, pD626, DOI 10.1093/nar/gkw1134
   Uchinaka A, 2017, PHARMACOL RES PERSPE, V5, DOI 10.1002/prp2.331
   Um SH, 2004, NATURE, V431, P200, DOI 10.1038/nature02866
   Vikman P, 2014, J MOL ENDOCRINOL, V53, pR93, DOI 10.1530/JME-14-0170
   Wang Z, 2009, NAT REV GENET, V10, P57, DOI 10.1038/nrg2484
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Yang Z, 2012, OBES REV, V13, P58, DOI 10.1111/j.1467-789X.2012.01038.x
   Zhao SR, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0078644
NR 48
TC 15
Z9 17
U1 2
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB
PY 2020
VL 21
IS 4
AR 1455
DI 10.3390/ijms21041455
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA KY4FE
UT WOS:000522524400282
PM 32093387
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Caimi, G
   Hopps, E
   Montana, M
   Carollo, C
   Calandrino, V
   Incalcaterra, E
   Canino, B
   Lo Presti, R
AF Caimi, G.
   Hopps, E.
   Montana, M.
   Carollo, C.
   Calandrino, V.
   Incalcaterra, E.
   Canino, B.
   Lo Presti, R.
TI Nitric oxide metabolites (nitrite and nitrate) in several clinical
   condition
SO CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
LA English
DT Article
DE NOx; hypertension; kidney disease; metabolic syndrome; OSAS; sistemic
   sclerosis; dialysis; AMI
ID ACUTE MYOCARDIAL-INFARCTION; OBSTRUCTIVE SLEEP-APNEA;
   CHRONIC-RENAL-FAILURE; OXIDATIVE STRESS; SYSTEMIC-SCLEROSIS;
   CARDIOGENIC-SHOCK; LEUKOCYTE ACTIVATION; SYNTHASE EXPRESSION; ADHESION
   MOLECULE-1; DIABETES-MELLITUS
AB We determined the concentration of nitric oxide metabolites (NO2-+ NO3-), expressed as NOx, in several clinical conditions. Regarding this, we have examined 25 subjects with arterial hypertension, 41 subjects with chronic kidney disease in conservative treatment, 106 subjects with metabolic syndrome subdivided according to the presence (n=43) or not (n=63) of diabetes mellitus, 48 subjects with obstructive sleep apnea syndrome (OSAS),14 women with systemic sclerosis complicated with Raynaud's phenomenon, 42 dialyzed subjects and 105 young subjects with acute myocardial infarction (AMI). In subjects with arterial hypertension, chronic kidney disease, metabolic syndrome, systemic sclerosis, as well as, in dialyzed and AMI subjects, we found at baseline a NOx increase. In dyalized subjects after a standard dialysis session, we observed a decrease in NOx. The increase in NOx in juvenile AMI was significantly influenced by cigarette smoking and less by cardiovascular risk factors and the extent of coronary lesions; at 3 and 12 months later than the initial event, we observed a decrease of NOx that remains significantly higher than the control group. In subjects with OSAS no difference in NOx was noted in comparison with normal controls, although their subdivision according to the apnea/hypopnea index operates a clear distinction regarding NOx concentration.
C1 [Caimi, G.; Hopps, E.; Montana, M.; Carollo, C.; Calandrino, V.; Incalcaterra, E.; Canino, B.; Lo Presti, R.] Univ Palermo, Dipartimento Biomed Med Interna & Specialist, I-90100 Palermo, Italy.
C3 University of Palermo
RP Caimi, G (corresponding author), Univ Palermo, Dipartimento Biomed Med Interna & Specialist, Via Vespro 129, I-90100 Palermo, Italy.
EM gregorio.caimi@unipa.it
RI Carollo, Caterina/AAT-3063-2021; Montaña, Fernanda/ADG-6031-2022; LO
   PRESTI, Rosalia/J-5394-2016
OI canino, baldassare/0000-0001-6024-331X; Caimi,
   Gregorio/0000-0001-8964-255X; LO PRESTI, Rosalia/0000-0002-7491-568X
CR Akiyama K, 1997, J MOL CELL CARDIOL, V29, P1, DOI 10.1006/jmcc.1996.9998
   Akiyama K, 1998, J AM COLL CARDIOL, V32, P373, DOI 10.1016/S0735-1097(98)00270-8
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Allanore Y, 2001, RHEUMATOLOGY, V40, P1089, DOI 10.1093/rheumatology/40.10.1089
   Andersen GN, 2000, ARTHRITIS RHEUM-US, V43, P1085
   Armas-Padilla Maria Cristina, 2007, Am J Ther, V14, P172, DOI 10.1097/01.pap.0000249914.75895.48
   Asl SZ, 2008, CLIN BIOCHEM, V41, P1342, DOI 10.1016/j.clinbiochem.2008.08.076
   Aydin A, 2001, CLIN BIOCHEM, V34, P65, DOI 10.1016/S0009-9120(00)00199-5
   Balistreri C.R., 2006, ANN NY ACAD SCI, V1067, P267
   Böger RH, 2003, ATHEROSCLEROSIS SUPP, V4, P23, DOI 10.1016/S1567-5688(03)00030-8
   Caimi G, 2010, CLIN HEMORHEOL MICRO, V46, P321, DOI 10.3233/CH-2010-1360
   Caimi G, 2009, BLOOD PURIFICAT, V27, P194, DOI 10.1159/000193218
   Caimi G, 2012, DIABETES METAB SYND, V6, P132, DOI 10.1016/j.dsx.2012.09.012
   Caimi G, 2009, CLIN HEMORHEOL MICRO, V43, P251, DOI 10.3233/CH-2009-1237
   Caimi G, 2008, CLIN HEMORHEOL MICRO, V40, P157, DOI 10.3233/CH-2008-1126
   Chedraui P, 2012, GYNECOL ENDOCRINOL, V28, P787, DOI 10.3109/09513590.2012.671395
   Chien WY, 2005, DIABETES METAB, V31, P63, DOI 10.1016/S1262-3636(07)70168-4
   Choi JW, 2004, CLIN CHIM ACTA, V347, P151, DOI 10.1016/j.cccn.2004.04.024
   Ciuffetti G, 2002, J HUM HYPERTENS, V16, P533, DOI 10.1038/sj.jhh.1001454
   Cosby K, 2003, NAT MED, V9, P1498, DOI 10.1038/nm954
   Cotter G, 2003, EUR HEART J, V24, P1287, DOI 10.1016/S0195-668X(03)00193-3
   de Jongh RT, 2004, CIRCULATION, V109, P2529, DOI 10.1161/01.CIR.0000129772.26647.6F
   Del Ben M, 2012, BMC PULM MED, V12, DOI 10.1186/1471-2466-12-36
   Di Renzo L, 2010, OBESITY, V18, P2125, DOI 10.1038/oby.2010.50
   Dooley A, 2006, RHEUMATOLOGY, V45, P676, DOI 10.1093/rheumatology/kei276
   Dzavík V, 2007, EUR HEART J, V28, P1109, DOI 10.1093/eurheartj/ehm075
   FAGRELL B, 1986, ANN BIOMED ENG, V14, P163, DOI 10.1007/BF02584267
   Forconi S, 2013, CLIN HEMORHEOL MICRO, V53, P3, DOI 10.3233/CH-2012-1571
   Forstermann U, 1995, Adv Pharmacol, V34, P171
   Franco CMR, 2012, J MOL NEUROSCI, V47, P300, DOI 10.1007/s12031-012-9738-0
   Ghasemi A, 2008, LIFE SCI, V83, P326, DOI 10.1016/j.lfs.2008.06.010
   Ginnan R, 2008, FREE RADICAL BIO MED, V44, P1232, DOI 10.1016/j.freeradbiomed.2007.12.025
   Gori T, 2012, CLIN HEMORHEOL MICRO, V52, P255, DOI 10.3233/CH-2012-1603
   Grimaldi MP, 2006, J LEUKOCYTE BIOL, V79, P611, DOI 10.1189/jlb.0705416
   Higashino H., 2010, J MED SCI, V10, P1, DOI [10.3923/jms.2010.1.11, DOI 10.3923/JMS.2010.1.11]
   Higashino H, 2007, CLIN EXP PHARMACOL P, V34, P725, DOI 10.1111/j.1440-1681.2007.04617.x
   Hochman JS, 2007, JAMA-J AM MED ASSOC, V297, P1657
   JUNG F, 1993, CLIN INVESTIGATOR, V71, P132
   Kedziora-Kornatowska K, 2004, CELL MOL BIOL LETT, V9, P635
   Kumar C A, 2000, Med Sci Monit, V6, P901
   Lavie L, 2003, J MOL NEUROSCI, V21, P57, DOI 10.1385/JMN:21:1:57
   Lio D, 2004, J MED GENET, V41, P790, DOI 10.1136/jmg.2004.019885
   Listì F, 2005, INT J CARDIOL, V102, P269, DOI 10.1016/j.ijcard.2004.05.031
   Listì F, 2004, EUR J IMMUNOGENET, V31, P175, DOI 10.1111/j.1365-2370.2004.00464.x
   Lo Presti R, 2008, TRACE ELEM ELECTROLY, V25, P211
   Lo Presti R., 2007, MINERVA CARDIOANGIOL, V55, P179
   López A, 2004, CRIT CARE MED, V32, P21, DOI 10.1097/01.CCM.0000105581.01815.C6
   LoPresti R, 2008, CLIN APPL THROMB-HEM, V14, P421, DOI 10.1177/1076029607308406
   LOUGHREY CM, 1994, Q J MED, V87, P679
   Lundberg JO, 2004, FREE RADICAL BIO MED, V37, P395, DOI 10.1016/j.freeradbiomed.2004.04.027
   Mackenzie IMJ, 1996, CLIN CHEM, V42, P440
   Mazzone A, 1999, EUR J CLIN INVEST, V29, P1
   Menkès CJ, 2001, B ACAD NAT MED PARIS, V185, P509, DOI 10.1016/S0001-4079(19)34536-4
   Millar TM, 1998, FEBS LETT, V427, P225, DOI 10.1016/S0014-5793(98)00430-X
   Modin A, 2001, ACTA PHYSIOL SCAND, V171, P9, DOI 10.1046/j.1365-201x.2001.171001009.x
   Mok MY, 2008, CLIN RHEUMATOL, V27, P315, DOI 10.1007/s10067-007-0708-9
   MONCADA S, 1991, PHARMACOL REV, V43, P109
   Nathan C, 1997, J CLIN INVEST, V100, P2417, DOI 10.1172/JCI119782
   Nicholls SJ, 2007, CIRCULATION, V116, P2315, DOI 10.1161/CIRCULATIONAHA.107.693986
   Olszanecka-Glinianowicz M., 2004, METABOLISM CLIN EXPT, V10, P1268
   Ouviña SM, 2001, THROMB RES, V102, P107, DOI 10.1016/S0049-3848(01)00237-7
   Oyama J, 2012, CLIN CARDIOL, V35, P231, DOI 10.1002/clc.21010
   Özden S, 2003, CAN J OPHTHALMOL, V38, P393, DOI 10.1016/S0008-4182(03)80051-0
   Pereira FO, 2006, MEDIAT INFLAMM, V2006, DOI 10.1155/MI/2006/39062
   Saitoh M, 2003, HEART VESSELS, V18, P177, DOI 10.1007/s00380-003-0715-y
   Salem R, 2007, CRIT CARE, V11, DOI 10.1186/cc5925
   Schulz R, 2000, THORAX, V55, P1046, DOI 10.1136/thorax.55.12.1046
   Sud A, 2000, NITRIC OXIDE-BIOL CH, V4, P615, DOI 10.1006/niox.2000.0309
   Surekha R. H., 2007, SMJ Singapore Medical Journal, V48, P137
   Takagi K, 2003, CLIN EXP IMMUNOL, V134, P538, DOI 10.1111/j.1365-2249.2003.02320.x
   Ulker P, 2009, BIORHEOLOGY, V46, P121, DOI 10.3233/BIR-2009-0532
   Ulker P., 2012, CLIN HEMORHEOLOGY MI
   Ulker P, 2011, NITRIC OXIDE-BIOL CH, V24, P184, DOI 10.1016/j.niox.2011.03.003
   Vyzantiadis T, 2006, CLIN EXP HYPERTENS, V28, P603, DOI 10.1080/10641960600945348
   Weinberg JB, 1998, MOL MED, V4, P557, DOI 10.1007/BF03401758
   WILDHIRT SM, 1995, INT J CARDIOL, V50, P253, DOI 10.1016/0167-5273(95)02385-A
   Yamamoto T, 1998, J RHEUMATOL, V25, P314
   Yoon JW, 2007, KIDNEY INT, V71, P167, DOI 10.1038/sj.ki.5002019
   Zavaroni I, 2004, AM J HYPERTENS, V17, P549, DOI 10.1016/j.amjhyper.2004.02.009
   Zhang DL, 2009, CLIN NEPHROL, V71, P405
NR 80
TC 32
Z9 33
U1 0
U2 8
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1386-0291
EI 1875-8622
J9 CLIN HEMORHEOL MICRO
JI Clin. Hemorheol. Microcirc.
PY 2014
VL 56
IS 4
BP 359
EP 369
DI 10.3233/CH-131758
PG 11
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA AI0GF
UT WOS:000336523500007
PM 24004551
OA Green Published
DA 2025-06-11
ER

PT J
AU He, CR
   Gai, HC
   Zhao, W
   Zhang, HQ
   Lai, L
   Ding, CY
   Chen, L
   Ding, J
AF He, Cairong
   Gai, Hongcun
   Zhao, Wen
   Zhang, Haiqin
   Lai, Lin
   Ding, Chenyu
   Chen, Lin
   Ding, Jie
TI Advances in the Study of Etiology and Molecular Mechanisms of
   Sensorineural Hearing Loss
SO CELL BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Review
DE Sensorineural hearing loss; Molecular mechanisms; Cell apoptosis;
   Mitochondrial impairment; Oxidative stress; Autophagy
ID CISPLATIN-INDUCED OTOTOXICITY; OTOFERLIN GENE OTOF; OXIDATIVE STRESS;
   INNER-EAR; APOPTOSIS; MUTATIONS; CELL; EXPRESSION; MICE; COCHLEA
AB Sensorineural hearing loss (SNHL), a multifactorial progressive disorder, results from a complex interplay of genetic and environmental factors, with its underlying mechanisms remaining unclear. Several pathological factors are believed to contribute to SNHL, including genetic factors, ion homeostasis, cell apoptosis, immune inflammatory responses, oxidative stress, hormones, metabolic syndrome, human cytomegalovirus infection, mitochondrial damage, and impaired autophagy. These factors collectively interact and play significant roles in the onset and progression of SNHL. The present review offers a comprehensive overview of the various factors that contribute to SNHL, emphasizes recent developments in understanding its etiology, and explores relevant preventive and intervention measures.
C1 [He, Cairong; Gai, Hongcun; Zhao, Wen; Zhang, Haiqin; Lai, Lin; Ding, Chenyu; Chen, Lin; Ding, Jie] Guizhou Univ, Inst Agrobioengn, Coll Life Sci, Key Lab Plant Resource Conservat & Germplasm Innov, Guiyang 550025, Guizhou, Peoples R China.
C3 Guizhou University
RP Ding, J (corresponding author), Guizhou Univ, Inst Agrobioengn, Coll Life Sci, Key Lab Plant Resource Conservat & Germplasm Innov, Guiyang 550025, Guizhou, Peoples R China.
EM jding@gzu.edu.cn
RI haiqin, zhang/JEZ-4562-2023; ding, chen/KDN-1285-2024
FU National Natural Science Foundation of China; Guizhou Province Science
   and Technology Planning Project [Qianke He Foundation-ZK [2021]]; 
   [32260163];  [81960838]
FX This research was funded by the National Natural Science Foundation of
   China (No.32260163; No.81960838); Guizhou Province Science and
   Technology Planning Project (Qianke He Foundation-ZK [2021] General
   108).
CR Akinpelu OV, 2014, LARYNGOSCOPE, V124, P767, DOI 10.1002/lary.24354
   Almishaal AA, 2017, PLOS PATHOG, V13, DOI 10.1371/journal.ppat.1006599
   Baker K, 2012, ANAT REC, V295, P1868, DOI 10.1002/ar.22594
   Balogová Z, 2018, FRONT AGING NEUROSCI, V9, DOI 10.3389/fnagi.2017.00428
   Bierhaus A, 2005, J MOL MED, V83, P876, DOI 10.1007/s00109-005-0688-7
   Blaser H, 2016, TRENDS CELL BIOL, V26, P249, DOI 10.1016/j.tcb.2015.12.002
   Böttger EC, 2013, HEARING RES, V303, P12, DOI 10.1016/j.heares.2013.01.006
   Borse V, 2017, CELL DEATH DIS, V8, DOI 10.1038/cddis.2017.314
   Borutaite V, 2010, ENVIRON MOL MUTAGEN, V51, P406, DOI 10.1002/em.20564
   Bowl MR, 2019, CSH PERSPECT MED, V9, DOI 10.1101/cshperspect.a033217
   Bradford RD, 2015, PLOS PATHOG, V11, DOI 10.1371/journal.ppat.1004774
   Brandt A, 2003, J NEUROSCI, V23, P10832
   Briston T, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-10673-8
   Carraro M, 2017, JARO-J ASSOC RES OTO, V18, P263, DOI 10.1007/s10162-016-0606-4
   Cavallaro G, 2023, MEDICINA-LITHUANIA, V59, DOI 10.3390/medicina59101718
   Cho SI, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-11894-2
   Choi BY, 2009, CLIN GENET, V75, P237, DOI 10.1111/j.1399-0004.2008.01128.x
   Contreras L, 2010, BBA-BIOENERGETICS, V1797, P607, DOI 10.1016/j.bbabio.2010.05.005
   Corvino V, 2018, CURR GENOMICS, V19, P327, DOI 10.2174/1389202919666171218163046
   Coulthard LR, 2009, TRENDS MOL MED, V15, P369, DOI 10.1016/j.molmed.2009.06.005
   de Beeck KO, 2011, HEARING RES, V281, P18, DOI 10.1016/j.heares.2011.07.002
   Rodríguez RD, 2015, HEARING RES, V330, P39, DOI 10.1016/j.heares.2015.07.020
   Defourny J, 2019, P NATL ACAD SCI USA, V116, P8010, DOI 10.1073/pnas.1821844116
   Dejean LM, 2005, MOL BIOL CELL, V16, P2424, DOI 10.1091/mbc.e04-12-1111
   Delmaghani S, 2006, NAT GENET, V38, P770, DOI 10.1038/ng1829
   Delmaghani S, 2015, CELL, V163, P894, DOI 10.1016/j.cell.2015.10.023
   Denamur S, 2011, FREE RADICAL BIO MED, V51, P1656, DOI 10.1016/j.freeradbiomed.2011.07.015
   Dhondt C, 2019, OTOL NEUROTOL, V40, pE636, DOI 10.1097/MAO.0000000000002244
   Ding B, 2014, AM J PHYSIOL-CELL PH, V306, pC66, DOI 10.1152/ajpcell.00096.2013
   Egilmez OK, 2016, SCIENTIFICA, V2016, DOI 10.1155/2016/7576064
   Fang B, 2014, BIOCHEM BIOPH RES CO, V448, P443, DOI 10.1016/j.bbrc.2014.04.123
   Fei T., 2023, CHINESE SCI J HEARIN, V21, P97, DOI [10.3969/j.issn.1672-4933.2023.01.026, DOI 10.3969/J.ISSN.1672-4933.2023.01.026]
   Feng YW, 2023, FRONT NEUROSCI-SWITZ, V17, DOI 10.3389/fnins.2023.1282663
   Fetoni AR, 2019, FREE RADICAL BIO MED, V135, P46, DOI 10.1016/j.freeradbiomed.2019.02.022
   Fettiplace R, 2006, NAT REV NEUROSCI, V7, P19, DOI 10.1038/nrn1828
   Frisina RD, 2016, AGING-US, V8, P2081, DOI 10.18632/aging.101045
   Frye MD, 2017, HEARING RES, V344, P125, DOI 10.1016/j.heares.2016.11.003
   Fu XL, 2021, FRONT CELL NEUROSCI, V15, DOI 10.3389/fncel.2021.692762
   Fujimoto C, 2017, CELL DEATH DIS, V8, DOI 10.1038/cddis.2017.194
   Fujimoto C, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/582849
   Fujioka M, 2006, J NEUROSCI RES, V83, P575, DOI 10.1002/jnr.20764
   Fukushima H, 2005, OTOLARYNG HEAD NECK, V133, P100, DOI 10.1016/j.otohns.2005.02.004
   Geng QW, 2021, EXP GERONTOL, V151, DOI 10.1016/j.exger.2021.111429
   Gregory GE, 2023, CLIN IMMUNOL, V249, DOI 10.1016/j.clim.2023.109287
   Hayashi K, 2020, GENES-BASEL, V11, DOI 10.3390/genes11111331
   Henderson D, 2006, EAR HEARING, V27, P1, DOI 10.1097/01.aud.0000191942.36672.f3
   Hilgert N, 2009, MUTAT RES-REV MUTAT, V681, P189, DOI 10.1016/j.mrrev.2008.08.002
   Hirose K, 2005, J COMP NEUROL, V489, P180, DOI 10.1002/cne.20619
   Homma K, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10092254
   Hu BH, 2009, NEUROSCIENCE, V161, P915, DOI 10.1016/j.neuroscience.2009.03.072
   Hu BH, 2002, HEARING RES, V166, P62, DOI 10.1016/S0378-5955(02)00286-1
   Igney FH, 2002, NAT REV CANCER, V2, P277, DOI 10.1038/nrc776
   Iwasa Y, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0215932
   Kaur T, 2011, CELL DEATH DIS, V2, DOI 10.1038/cddis.2011.63
   Keithley EM, 2005, HEARING RES, V209, P76, DOI 10.1016/j.heares.2005.06.009
   KERR JFR, 1972, BRIT J CANCER, V26, P239, DOI 10.1038/bjc.1972.33
   Kim J, 2014, BIOCHEM BIOPH RES CO, V449, P183, DOI 10.1016/j.bbrc.2014.04.118
   Knipper M, 1998, DEVELOPMENT, V125, P3709
   Kros CJ, 2019, CSH PERSPECT MED, V9, DOI 10.1101/cshperspect.a033548
   Kujoth GC, 2005, SCIENCE, V309, P481, DOI 10.1126/science.1112125
   Lassale C, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-04526-7
   Le Prell CG, 2007, HEARING RES, V226, P22, DOI 10.1016/j.heares.2006.10.006
   Levano S, 2015, CELL DEATH DIS, V6, DOI 10.1038/cddis.2015.362
   Li HZ, 2015, FRONT CELL NEUROSCI, V9, DOI 10.3389/fncel.2015.00130
   Li XX, 2023, FRONT SYNAPTIC NEURO, V14, DOI 10.3389/fnsyn.2022.1101587
   Li XY, 2016, J AM ACAD AUDIOL, V27, P345, DOI 10.3766/jaaa.15061
   Li XY, 2014, INT J PEDIATR OTORHI, V78, P995, DOI 10.1016/j.ijporl.2014.03.013
   Liu J, 2005, CELL RES, V15, P36, DOI 10.1038/sj.cr.7290262
   Liu SW, 2012, GENE, V499, P309, DOI 10.1016/j.gene.2012.01.084
   Liu WW, 2021, AUTOPHAGY, V17, P4159, DOI 10.1080/15548627.2021.1905466
   Liu X, 2021, NAT REV DRUG DISCOV, V20, P384, DOI 10.1038/s41573-021-00154-z
   Maciaszczyk K, 2008, NEUROENDOCRINOL LETT, V29, P29
   Maeda Y, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0058775
   Maljevic S, 2010, PFLUG ARCH EUR J PHY, V460, P277, DOI 10.1007/s00424-010-0831-3
   Mammano F, 2007, PHYSIOLOGY, V22, P131, DOI 10.1152/physiol.00040.2006
   Mullur R, 2014, PHYSIOL REV, V94, P355, DOI 10.1152/physrev.00030.2013
   Nagai H, 2007, J BIOCHEM MOL BIOL, V40, P1
   Naples JG, 2017, MED HYPOTHESES, V104, P121, DOI 10.1016/j.mehy.2017.05.036
   Nicotera TM, 2003, JARO-J ASSOC RES OTO, V4, P466, DOI 10.1007/s10162-002-3038-2
   Ohinata Y, 2000, BRAIN RES, V878, P163, DOI 10.1016/S0006-8993(00)02733-5
   Okur MN, 2022, ANN BIOMED ENG, V50, P1762, DOI 10.1007/s10439-022-03103-y
   Pang JQ, 2019, FRONT CELL NEUROSCI, V12, DOI 10.3389/fncel.2018.00515
   Rivas A, 2005, OTOL NEUROTOL, V26, P415, DOI 10.1097/01.mao.0000169764.00798.84
   Rodríguez-Ballesteros M, 2008, HUM MUTAT, V29, P823, DOI 10.1002/humu.20708
   Roux I, 2006, CELL, V127, P277, DOI 10.1016/j.cell.2006.08.040
   Rybak LP, 2007, HEARING RES, V226, P157, DOI 10.1016/j.heares.2006.09.015
   [塞娜 Sai Na], 2018, [中华耳科学杂志, Chinese Journal of Otology], V16, P221
   Saidia AR, 2023, J CLIN MED, V12, DOI 10.3390/jcm12030738
   Sang L, 2017, INT J MOL MED, V40, P146, DOI 10.3892/ijmm.2017.3004
   Sangiuliano B, 2014, MEDIAT INFLAMM, V2014, DOI 10.1155/2014/821043
   Scherz-Shouval R, 2007, TRENDS CELL BIOL, V17, P422, DOI 10.1016/j.tcb.2007.07.009
   Shi JJ, 2015, NATURE, V526, P660, DOI 10.1038/nature15514
   Sloan-Heggen CM, 2016, HUM GENET, V135, P441, DOI 10.1007/s00439-016-1648-8
   Someya S, 2008, NEUROBIOL AGING, V29, P1080, DOI 10.1016/j.neurobiolaging.2007.01.014
   Stenberg AE, 2001, HEARING RES, V157, P87, DOI 10.1016/S0378-5955(01)00280-5
   Syka J, 2010, HEARING RES, V264, P70, DOI 10.1016/j.heares.2009.11.003
   Takeuchi O, 2010, CELL, V140, P805, DOI 10.1016/j.cell.2010.01.022
   Tang K, 2019, MITOCHONDRIAL DNA A, V30, P345, DOI 10.1080/24701394.2018.1527910
   Thakkar R, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/8309031
   Trifunovic A, 2004, NATURE, V429, P417, DOI 10.1038/nature02517
   Vethanayagam RR, 2016, CELL DEATH DIS, V7, DOI 10.1038/cddis.2016.156
   Vicente-Torres MA, 2006, J NEUROSCI RES, V83, P1564, DOI 10.1002/jnr.20832
   Waissbluth S, 2022, FRONT NEUROSCI-SWITZ, V16, DOI 10.3389/fnins.2022.867034
   Wan HZ, 2022, FRONT CELL NEUROSCI, V16, DOI 10.3389/fncel.2022.966202
   Wang XL, 2023, BIOMED PHARMACOTHER, V157, DOI 10.1016/j.biopha.2022.114045
   Wang XX., 2023, CHINESE J OPHTHALMOL, V23, P175, DOI [10.14166/j.issn.1671-2420.2023.02.015, DOI 10.14166/J.ISSN.1671-2420.2023.02.015]
   Wang YJ, 2023, FRONT CELL NEUROSCI, V17, DOI 10.3389/fncel.2023.1208406
   Wangemann P, 2002, HEARING RES, V165, P1, DOI 10.1016/S0378-5955(02)00279-4
   Wei X, 2005, NEUROSCIENCE, V131, P513, DOI 10.1016/j.neuroscience.2004.11.014
   White K, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-23436-w
   Whitfield J, 2001, NEURON, V29, P629, DOI 10.1016/S0896-6273(01)00239-2
   Williamson TT, 2020, J NEUROSCI RES, V98, P1721, DOI 10.1002/jnr.24588
   Williamson TT, 2019, AGING CELL, V18, DOI 10.1111/acel.12939
   Wingard JC, 2015, FRONT CELL NEUROSCI, V9, DOI 10.3389/fncel.2015.00202
   Wu JH, 2020, CELL PROLIFERAT, V53, DOI 10.1111/cpr.12915
   Wu T., 2023, STUDY REGULATORY MEC
   Xia WW, 2021, FRONT MICROBIOL, V12, DOI 10.3389/fmicb.2021.649690
   Xiang-Xiang W., 2023, CHINESE SCI J HEARIN, V21, P56, DOI [10.3969/j.issn.1672-4933.2023.01.014, DOI 10.3969/J.ISSN.1672-4933.2023.01.014]
   Xu JS, 2021, P NATL ACAD SCI USA, V118, DOI 10.1073/pnas.2025196118
   Yamagishi S, 2005, CURR DIABETES REV, V1, P93, DOI 10.2174/1573399052952631
   Yang QQ, 2018, FRONT MOL NEUROSCI, V11, DOI 10.3389/fnmol.2018.00403
   Yang QQ, 2018, FREE RADICAL BIO MED, V120, P342, DOI 10.1016/j.freeradbiomed.2018.02.025
   Ye B, 2019, AUTOPHAGY, V15, P998, DOI 10.1080/15548627.2019.1569926
   Yu WT, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.823439
   Yuan H, 2015, ANTIOXID REDOX SIGN, V22, P1308, DOI 10.1089/ars.2014.6004
   [张国平 Zhang Guoping], 2018, [中华耳科学杂志, Chinese Journal of Otology], V16, P701
   Zhang LN, 2013, DIABETES, V62, P1297, DOI 10.2337/db12-0703
   Zong L, 2017, BIOCHEM BIOPH RES CO, V489, P223, DOI 10.1016/j.bbrc.2017.05.137
NR 128
TC 0
Z9 0
U1 6
U2 7
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1085-9195
EI 1559-0283
J9 CELL BIOCHEM BIOPHYS
JI Cell Biochem. Biophys.
PD SEP
PY 2024
VL 82
IS 3
BP 1721
EP 1734
DI 10.1007/s12013-024-01344-3
EA JUN 2024
PG 14
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA H6B3R
UT WOS:001243256500001
PM 38849694
DA 2025-06-11
ER

PT J
AU Faugere, M
   Maakaron, E
   Achour, V
   Verney, P
   Andrieu-Haller, C
   Obadia, J
   Fond, G
   Lançon, C
   Korchia, T
AF Faugere, Melanie
   Maakaron, Eloise
   Achour, Vincent
   Verney, Pierre
   Andrieu-Haller, Christelle
   Obadia, Jade
   Fond, Guillaume
   Lancon, Christophe
   Korchia, Theo
TI Vitamin D, B9, and B12 Deficiencies as Key Drivers of Clinical Severity
   and Metabolic Comorbidities in Major Psychiatric Disorders
SO NUTRIENTS
LA English
DT Article
DE vitamin D deficiency; folate; vitamin B12; schizophrenia; depression;
   bipolar disorder; psychiatric symptoms; metabolic syndrome; nutritional
   psychiatry
ID BIPOLAR DISORDER; DEPRESSION; FOLATE; HOMOCYSTEINE; SCHIZOPHRENIA;
   ASSOCIATION; DISEASE; NEUROINFLAMMATION; SUPPLEMENTATION; METAANALYSIS
AB Background/Objectives: Severe mental illnesses such as schizophrenia, major depressive disorder, and bipolar disorder are often accompanied by metabolic comorbidities. While the role of vitamins in physical health is well-established, their involvement in psychiatric disorders has garnered increasing attention in recent years. Methods: We conducted a cross-sectional analysis of 1003 patients diagnosed with severe mental illnesses. Vitamin D, B9, and B12 serum levels were measured, and deficiencies were defined using established clinical cutoffs. Multivariate regression analyses were performed to identify associations between vitamin deficiencies and clinical outcomes. Results: Our findings revealed that vitamin deficiencies were prevalent across all diagnostic groups, with particularly high rates in patients with schizophrenia and major depressive disorder. Vitamin D deficiency was significantly associated with worse psychiatric outcomes, including increased depressive symptoms (adjusted OR = 1.89, p = 0.018), lower Global Assessment of Functioning scores (adjusted OR = -0.18, p < 0.001), and higher rates of metabolic syndrome (adjusted OR = 1.97, p = 0.007). Folate and B12 deficiencies were also linked to greater psychiatric symptom severity and metabolic disturbances, including increased risks of obesity and dyslipidemia. Conclusions: Our study highlights the critical role of vitamins deficiencies in both psychiatric and metabolic health of patients with severe mental illnesses. These findings underscore the importance of routine screening and correction of these deficiencies as part of comprehensive care in psychiatric populations. The integration of nutritional interventions may offer a novel and holistic approach to improving both mental and physical health outcomes.
C1 [Faugere, Melanie; Maakaron, Eloise; Achour, Vincent; Verney, Pierre; Andrieu-Haller, Christelle; Obadia, Jade; Fond, Guillaume; Lancon, Christophe; Korchia, Theo] Sainte Marguer Univ Hosp, Assistance Publ Hop Marseille, Dept Acad Psychiat, F-13009 Marseille, France.
   [Faugere, Melanie; Maakaron, Eloise; Achour, Vincent; Verney, Pierre; Andrieu-Haller, Christelle; Obadia, Jade; Fond, Guillaume; Lancon, Christophe; Korchia, Theo] Aix Marseille Univ, Assistance Publ Hop Marseille, Hlth Serv Res & Qual Life Ctr CEReSS, UR3279, F-13005 Marseille, France.
   [Faugere, Melanie; Lancon, Christophe] Ctr Rech St Mentale & Psychiat Reg PACA, Groupement Cooperat Sanit, F-13100 Aix En Provence, France.
   [Faugere, Melanie] CHU Sainte Marguer, Serv Pr Christophe Lancon, Pavillon Solaris,270 Blvd St Marguer, F-13009 Marseille, France.
C3 Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille;
   Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille
RP Faugere, M (corresponding author), Sainte Marguer Univ Hosp, Assistance Publ Hop Marseille, Dept Acad Psychiat, F-13009 Marseille, France.; Faugere, M (corresponding author), Aix Marseille Univ, Assistance Publ Hop Marseille, Hlth Serv Res & Qual Life Ctr CEReSS, UR3279, F-13005 Marseille, France.; Faugere, M (corresponding author), Ctr Rech St Mentale & Psychiat Reg PACA, Groupement Cooperat Sanit, F-13100 Aix En Provence, France.; Faugere, M (corresponding author), CHU Sainte Marguer, Serv Pr Christophe Lancon, Pavillon Solaris,270 Blvd St Marguer, F-13009 Marseille, France.
EM melanie.faugere@ap-hm.fr; eloise.maakaron@ap-hm.fr;
   vincent.achour@ap-hm.fr; pierre.verney@ap-hm.fr;
   christelle.andrieu@ap-hm.fr; jade.obadia@ap-hm.fr;
   guillaume.fond@gmail.com; christophe.lancon@ap-hm.fr;
   theo.korchia@ap-hm.fr
RI Faugere, Melanie/JCP-3459-2023
CR Abdelwahab M.M., 2024, Nutrition and Psychiatric Disorders, P307, DOI [10.1007/978-981-97-2681-314, DOI 10.1007/978-981-97-2681-314]
   ADDINGTON D, 1993, BRIT J PSYCHIAT, V163, P39, DOI 10.1192/S0007125000292581
   Ahmed HM, 2024, INT J PSYCHIAT CLIN, V28, P35, DOI 10.1080/13651501.2024.2310847
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alimohammadi-Kamalabadi M, 2024, HEALTH SCI REP-US, V7, DOI 10.1002/hsr2.2276
   American Psychiatric Association (APA), 2013, Diagnostic and Statistical Manual of Mental Disorders, V5th ed
   Anglin RES, 2013, BRIT J PSYCHIAT, V202, P100, DOI 10.1192/bjp.bp.111.106666
   Ashok T, 2021, CUREUS J MED SCIENCE, V13, DOI 10.7759/cureus.18521
   Bagheri S, 2022, J ADDICT DIS, V40, P382, DOI 10.1080/10550887.2021.2010971
   Baltrusch S, 2021, BIOMED RES INT, V2021, DOI 10.1155/2021/9968228
   Batinic B, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.784370
   Beckett E. L., 2016, Journal of Nutrition & Intermediary Metabolism, V6, P8, DOI 10.1016/j.jnim.2016.04.010
   Bender A, 2017, J PSYCHIATR RES, V95, P9, DOI 10.1016/j.jpsychires.2017.07.019
   Berk M, 2023, WORLD PSYCHIATRY, V22, P366, DOI 10.1002/wps.21110
   Bermudez Echeverry M., 2022, B-Complex VitaminsSources, Intakes and Novel Applications
   Blom JD, 2024, PSYCHOPATHOLOGY, V57, P492, DOI 10.1159/000540003
   Boachie J, 2020, NUTRIENTS, V12, DOI 10.3390/nu12071925
   Borges-Vieira JG, 2023, NUTR NEUROSCI, V26, P187, DOI 10.1080/1028415X.2022.2031494
   Bottiglieri T, 1996, NUTR REV, V54, P382, DOI 10.1111/j.1753-4887.1996.tb03851.x
   Brown HE, 2014, CNS DRUGS, V28, P611, DOI 10.1007/s40263-014-0172-4
   Buckley PF, 2019, CURR PSYCHIAT REP, V21, DOI 10.1007/s11920-019-1050-z
   Calvello R, 2017, J NEUROIMMUNE PHARM, V12, P327, DOI 10.1007/s11481-016-9720-7
   Carnegie RE, 2024, NUTRIENTS, V16, DOI 10.3390/nu16213690
   Cui XY, 2022, NUTRIENTS, V14, DOI 10.3390/nu14204353
   Cui XY, 2021, MOL PSYCHIATR, V26, P2708, DOI 10.1038/s41380-021-01025-0
   Dal N, 2024, CURR NUTR REP, V13, P69, DOI 10.1007/s13668-024-00520-4
   Doane MJ, 2023, BMC PSYCHIATRY, V23, DOI 10.1186/s12888-023-04746-4
   Etgen T, 2012, DEMENT GERIATR COGN, V33, P297, DOI 10.1159/000339702
   Fan N, 2024, FRONT PSYCHIATRY, V15, DOI 10.3389/fpsyt.2024.1380900
   Feng TM, 2020, CURR BEHAV NEUROSCI, V7, P128, DOI 10.1007/s40473-020-00207-4
   Fetahu IS, 2014, FRONT PHYSIOL, V5, DOI 10.3389/fphys.2014.00164
   Folstein M, 2007, AM J PSYCHIAT, V164, P861, DOI 10.1176/appi.ajp.164.6.861
   Fond G, 2018, PSYCHIAT RES, V270, P104, DOI 10.1016/j.psychres.2018.09.024
   Fornaro M, 2025, MOL PSYCHIATR, V30, P168, DOI 10.1038/s41380-024-02645-y
   Fraguas D, 2019, SCHIZOPHRENIA BULL, V45, P742, DOI 10.1093/schbul/sby125
   Garcia A, 2004, CAN MED ASSOC J, V171, P897, DOI 10.1503/cmaj.1031586
   Garcia-Serna AM, 2020, MOL PSYCHIATR, V25, P2468, DOI 10.1038/s41380-019-0357-9
   Gilbody S, 2007, J EPIDEMIOL COMMUN H, V61, P631, DOI 10.1136/jech.2006.050385
   Giménez VMM, 2023, CURR PROTEIN PEPT SC, V24, P533, DOI 10.2174/1389203724666230622162539
   Goltzman D, 2018, HISTOCHEM CELL BIOL, V149, P305, DOI 10.1007/s00418-018-1648-y
   Green R., 2017, Nature Reviews Disease Primers, V3, P1, DOI DOI 10.1038/NRDP.2017.40
   Greenberg PE, 2021, PHARMACOECONOMICS, V39, P653, DOI 10.1007/s40273-021-01019-4
   Halaris A, 2021, J PERS MED, V11, DOI 10.3390/jpm11020155
   HEATHERTON TF, 1991, BRIT J ADDICT, V86, P1119
   Hoepner CT, 2021, NUTRIENTS, V13, DOI 10.3390/nu13030767
   Hong H, 2016, INT NEUROUROL J, V20, pS2, DOI 10.5213/inj.1632604.302
   Howes OD, 2024, NAT REV NEUROL, V20, P22, DOI 10.1038/s41582-023-00904-0
   Hu YM, 2024, NUTRIENTS, V16, DOI 10.3390/nu16131986
   Jahan-Mihan A, 2024, NUTRIENTS, V16, DOI 10.3390/nu16121902
   Jakubowski H, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25158095
   Jiang MM, 2023, NUTRIENTS, V15, DOI 10.3390/nu15184051
   Julian LJ, 2011, ARTHRIT CARE RES, V63, pS467, DOI 10.1002/acr.20561
   Kadakia A, 2022, J CLIN PSYCHIAT, V83, DOI 10.4088/JCP.22m14458
   Kanagasundaram P, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.642403
   Kaviani M, 2022, BMC PSYCHIATRY, V22, DOI 10.1186/s12888-022-04305-3
   Kaviani M, 2020, J AFFECT DISORDERS, V269, P28, DOI 10.1016/j.jad.2020.03.029
   Kennedy DO, 2016, NUTRIENTS, V8, DOI 10.3390/nu8020068
   Kennedy KP, 2024, CURR PSYCHIAT REP, V26, P265, DOI 10.1007/s11920-024-01505-4
   Landaas ET, 2016, BJPSYCH OPEN, V2, P377, DOI 10.1192/bjpo.bp.116.003491
   Lardner AL, 2015, FRONT MOL NEUROSCI, V8, DOI 10.3389/fnmol.2015.00058
   Lioudyno VI, 2024, BIOCHEMISTRY-MOSCOW+, V89, P562, DOI 10.1134/S0006297924030143
   Ma F, 2017, NUTRIENTS, V9, DOI 10.3390/nu9070725
   Ma Q, 2020, SCHIZOPHRENIA BULL, V46, P699, DOI 10.1093/schbul/sbz111
   Majd M, 2020, FRONT NEUROENDOCRIN, V56, DOI 10.1016/j.yfrne.2019.100800
   Mandal PK, 2022, ACS CHEM NEUROSCI, V13, P2784, DOI 10.1021/acschemneuro.2c00420
   Markun S, 2021, NUTRIENTS, V13, DOI 10.3390/nu13030923
   Martinez-Iglesias O, 2023, GENES-BASEL, V14, DOI 10.3390/genes14020365
   Marx W, 2017, P NUTR SOC, V76, P427, DOI 10.1017/S0029665117002026
   Mathew SJ, 2017, AM J PSYCHIAT, V174, P3, DOI 10.1176/appi.ajp.2016.16101154
   Mazereel V, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.573479
   Micoulaud-Franchi JA, 2018, PSYCHIAT RES, V268, P68, DOI 10.1016/j.psychres.2018.06.062
   Mikkelsen K, 2016, MATURITAS, V93, P108, DOI 10.1016/j.maturitas.2016.08.001
   Milaneschi Y, 2014, MOL PSYCHIATR, V19, P444, DOI 10.1038/mp.2013.36
   Mo HF, 2023, BMC PSYCHIATRY, V23, DOI 10.1186/s12888-023-04685-0
   Mohammadi A, 2024, NEUROPSYCHOPHARM REP, V44, P389, DOI 10.1002/npr2.12431
   Musazadeh V, 2023, PHARMACOL RES, V187, DOI 10.1016/j.phrs.2022.106605
   Neriman A, 2021, BMC PSYCHIATRY, V21, DOI 10.1186/s12888-021-03308-w
   Nilsson K, 2010, CLIN BIOCHEM, V43, P1056, DOI 10.1016/j.clinbiochem.2010.03.013
   Osman A, 2001, ASSESSMENT, V8, P443, DOI 10.1177/107319110100800409
   Ostrakhovitch EA, 2019, AGEING RES REV, V49, P144, DOI 10.1016/j.arr.2018.10.010
   Owen MJ, 2016, LANCET, V388, P86, DOI 10.1016/S0140-6736(15)01121-6
   Payne JL, 2020, PSYCHIAT RES, V285, DOI 10.1016/j.psychres.2019.112711
   Petruso Flavia, 2023, Neuronal Signal, V7, pNS20220077, DOI 10.1042/NS20220077
   Quadros EV, 2023, NUTRIENTS, V15, DOI 10.3390/nu15112525
   Rhie SJ, 2020, J EXERC REHABIL, V16, P2, DOI 10.12965/jer.2040016.008
   Roffman JL, 2018, MOL PSYCHIATR, V23, P316, DOI 10.1038/mp.2017.41
   Saarni SI, 2010, BRIT J PSYCHIAT, V197, P386, DOI 10.1192/bjp.bp.109.076489
   Saether LS, 2023, MOL PSYCHIATR, V28, P1284, DOI 10.1038/s41380-022-01924-w
   Sahu P, 2022, VITAM HORM, V119, P457, DOI 10.1016/bs.vh.2022.01.001
   Sailike B, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25147809
   Sangle P, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.11169
   Saraswathy KN, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0748-y
   Spielberger C., 1980, Stress and anxiety, V7
   Stanger O, 2009, EXPERT REV NEUROTHER, V9, P1393, DOI 10.1586/ERN.09.75
   Startup M, 2002, BRIT J CLIN PSYCHOL, V41, P417, DOI 10.1348/014466502760387533
   Swartz HA, 2012, J CLIN PSYCHIAT, V73, P1563, DOI 10.4088/JCP.12ac08227
   Syed Ehsan Ullah, 2013, Open Neurol J, V7, P44, DOI 10.2174/1874205X01307010044
   Taylor MJ, 2004, J PSYCHOPHARMACOL, V18, P251, DOI 10.1177/0269881104042630
   Tobin D, 2024, NUTRIENTS, V16, DOI 10.3390/nu16162806
   Troubat R, 2021, EUR J NEUROSCI, V53, P151, DOI 10.1111/ejn.14720
   Tsiglopoulos J, 2021, SCHIZOPHR RES, V237, P79, DOI 10.1016/j.schres.2021.08.001
   Tuo LJ, 2023, J STEROID BIOCHEM, V231, DOI 10.1016/j.jsbmb.2023.106313
   Ulloque-Badaracco JR, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1221259
   van Marwijk HWJ, 2015, BMC CARDIOVASC DISOR, V15, DOI 10.1186/s12872-015-0036-y
   Wang Y, 2020, NUTR RES, V81, P71, DOI 10.1016/j.nutres.2020.07.006
   Ware J. E., 1994, SF-36 physical and mental summary scales: A users manual
   Yang YF, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00052
   Young LM, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092232
   Zajkowska I, 2024, NUTRIENTS, V16, DOI 10.3390/nu16142228
   Zhou ZJ, 2023, FRONT PHARMACOL, V14, DOI 10.3389/fphar.2023.1135516
   Zhu HD, 2013, J PEDIATR-US, V162, P1004, DOI 10.1016/j.jpeds.2012.10.059
   Zhu Y, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00253
NR 112
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR 27
PY 2025
VL 17
IS 7
AR 1167
DI 10.3390/nu17071167
PG 24
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1HC1H
UT WOS:001464872100001
PM 40218925
DA 2025-06-11
ER

PT J
AU Ersoy, S
   Engin, VS
AF Ersoy, Suleyman
   Engin, Velittin Selcuk
TI Risk factors for polypharmacy in older adults in a primary care setting:
   a cross-sectional study
SO CLINICAL INTERVENTIONS IN AGING
LA English
DT Article
DE polypharmacy; older adult; primary care; Geriatric Depression Scale;
   metabolic syndrome; neutrophililymphocyte ratio
ID MINI-MENTAL-STATE; ANTIPSYCHOTIC POLYPHARMACY; PREVALENCE; MOBILITY;
   DISEASES; SCALE; GO
AB Purpose: Polypharmacy (PP) is a clinical challenge in older adults. Therefore, assessment of daily drug consumption (DDC) and its relationships is important. First-line health services have a crucial role in monitoring and prevenfmg PP. In this study, we aimed to assess DDC and investigate the risk factors for higher DDC among older adults in a pi-Unary care setting.
   Patients and methods: A total of 1,000 patients aged 65 years who visited Melek Ilatun Family Practice Center between December I, 2014, and August 1, 2017, were enrolled in the study. All patients were seen either at the center or in their homes, and informed consent was obtained. Comprehensive geriatric assessment was performed for each subject. Data were analyzed using SPSS software (version 17). The daily number of medicines that each patient used (DDC) regardless of whether they were prescribed was the dependent variable. Relationships between DDC and other continuous variables were examined using Pearson's correlation. For between-group comparisons of DDC, Student's i-tests were performed.
   Results: Univariate tests showed relationships between DDC and various demographic and clinical parameters. The variables that remained significant at the last step of a stepwise linear regression analysis were metabolic syndrome, chronic NM, incontinence, increased serum creatinine level, increased Geriatric Depression Scale scores, reported gastric disturbances, and neutrophil lymphocyte ratio.
   Conclusion: Along With certain chronic conditions, depressive symptoms and an inflammatory marker (neutrophillymphocyte ratio) significantly and independently related to higher DDC. Longitudinal and larger studies are ceded to further explore the multifaceted relationships of PP.
C1 [Ersoy, Suleyman] Karabuk Univ, Dept Family Med, Fac Med, Alparslan Cad Sirinevler, Karabuk, Turkey.
   [Engin, Velittin Selcuk] Minist Hlth, Melekhatun Family Practice Ctr, TR-34340 Istanbul, Turkey.
C3 Karabuk University; Ministry of Health - Turkey
RP Ersoy, S (corresponding author), Karabuk Univ, Dept Family Med, Fac Med, Alparslan Cad Sirinevler, Karabuk, Turkey.
EM suleymanersoy@gmail.com
RI Ersoy, Suleyman/ABF-9062-2021; engin, velittin selcuk/AAF-8297-2019
OI engin, velittin selcuk/0000-0002-6338-4748; Ersoy,
   Suleyman/0000-0003-0001-9329
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Alwan A, 2010, GLOBAL STATUS REPORT
   [Anonymous], CENS RES 2017
   [Anonymous], 2015, STESASERA390
   [Anonymous], 2008, REPORT WHO EXPERT CO
   [Anonymous], 2016, Journal of Continuing Medical Education
   [Anonymous], GLOSS TERMS COMM HLT
   [Anonymous], 2010, R PACKAGE VERSION
   [Anonymous], GERIATRI
   [Anonymous], ENDOSCOPY
   [Anonymous], UR INC AD CLIN PRACT
   [Anonymous], TURKIYE KLINIKLERI J
   ARSLAN S., 2000, Turk Geriatri Dergisi, V3, P56
   Babacan-Yildiz G, 2016, TURK PSIKIYATR DERG, V27, P41
   Bhat T, 2013, EXPERT REV CARDIOVAS, V11, P55, DOI [10.1586/erc.12.159, 10.1586/ERC.12.159]
   Chao CT, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000001251
   Correll CU, 2007, SCHIZOPHR RES, V89, P91, DOI 10.1016/j.schres.2006.08.017
   Discigil G, 2006, Turkish Journal of Geriatrics, V9, P117
   Ertan T, 1999, 2 INT S NEUR NEUR AS
   Esengen S., 2000, Trk Geriatri Dergisi, V3, P6
   Fishbain DA, 2005, AM J PHYS MED REHAB, V84, pS56, DOI 10.1097/01.PHM.0000154904.83278.32
   FOLSTEIN MF, 1975, J PSYCHIAT RES, V12, P189, DOI 10.1016/0022-3956(75)90026-6
   Frutos Bernal Elisa, 2011, Rev Esp Geriatr Gerontol, V46, P303, DOI 10.1016/j.regg.2011.03.002
   Grubb BP, 2008, CIRCULATION, V117, P2814, DOI 10.1161/CIRCULATIONAHA.107.761643
   Gungen Can, 2002, Turk Psikiyatri Derg, V13, P273
   Hippius M, 2005, INT J CLIN PHARM TH, V43, P406
   Hogan DB, 1997, CAN MED ASSOC J, V157, P1071
   Hubbard RE, 2015, MED J AUSTRALIA, V202, P373, DOI 10.5694/mja13.00172
   Jokanovic N, 2016, J EVAL CLIN PRACT, V22, P677, DOI 10.1111/jep.12514
   Jones SA, 2013, POSTGRAD MED J, V89, P247, DOI 10.1136/postgradmedj-2012-130889
   Jörgensen T, 2001, ANN PHARMACOTHER, V35, P1004, DOI 10.1345/aph.10351
   Junius-Walker U, 2007, FAM PRACT, V24, P14, DOI 10.1093/fampra/cml067
   Jyrkkä J, 2006, EUR J CLIN PHARMACOL, V62, P151, DOI 10.1007/s00228-005-0079-6
   Kashyap M, 2013, BMC GERIATR, V13, DOI 10.1186/1471-2318-13-57
   KATZ S, 1963, JAMA-J AM MED ASSOC, V185, P914, DOI 10.1001/jama.1963.03060120024016
   Kaya MG, 2013, TURK KARDIYOL DERN A, V41, P191, DOI 10.5543/tkda.2013.84484
   Kotlinska-Lemieszek A, 2014, J PAIN SYMPTOM MANAG, V48, P1145, DOI 10.1016/j.jpainsymman.2014.03.008
   Kutsal YG, 2009, J AM MED DIR ASSOC, V10, P486, DOI 10.1016/j.jamda.2009.03.018
   LAWTON MP, 1969, GERONTOLOGIST, V9, P179, DOI 10.1093/geront/9.3_Part_1.179
   Lim LM, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0173466
   Mangoni AA, 2004, BRIT J CLIN PHARMACO, V57, P6, DOI 10.1046/j.1365-2125.2003.02007.x
   Marques Larissa Pruner, 2015, Rev. bras. epidemiol., V18, P595, DOI 10.1590/1980-5497201500030006
   McNeil MJ, 2016, J PAIN SYMPTOM MANAG, V51, P178, DOI 10.1016/j.jpainsymman.2015.09.003
   McStea M, 2016, POSTGRAD MED, V128, P797, DOI 10.1080/00325481.2016.1229103
   Misawa F, 2011, BMC PSYCHIATRY, V11, DOI 10.1186/1471-244X-11-118
   Mizokami F, 2012, AM J GERIATR PHARMAC, V10, P123, DOI 10.1016/j.amjopharm.2012.02.003
   Montorio I, 1996, Int Psychogeriatr, V8, P103, DOI 10.1017/S1041610296002505
   O'Dwyer M, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2015-010505
   Onder G, 2012, J GERONTOL A-BIOL, V67, P698, DOI 10.1093/gerona/glr233
   Paladini A, 2015, PAIN PHYSICIAN, V18, pE863
   PODSIADLO D, 1991, J AM GERIATR SOC, V39, P142, DOI 10.1111/j.1532-5415.1991.tb01616.x
   Raîche M, 2000, LANCET, V356, P1001, DOI 10.1016/S0140-6736(00)02695-7
   ROSEN WG, 1984, AM J PSYCHIAT, V141, P1356
   Blix HS, 2006, NEPHROL DIAL TRANSPL, V21, P3164, DOI 10.1093/ndt/gfl399
   Shumway-Cook A, 2000, PHYS THER, V80, P896, DOI 10.1093/ptj/80.9.896
   Slabaugh SL, 2010, DRUG AGING, V27, P1019, DOI 10.2165/11584990-000000000-00000
   Takeuchi H, 2015, CAN J PSYCHIAT, V60, P215, DOI 10.1177/070674371506000503
   Talasz H, 2012, Z GERONTOL GERIATR, V45, P464, DOI 10.1007/s00391-012-0358-7
   Team R. C., 2013, R: A Language and Environment for Statistical Computing
   TINETTI ME, 1986, J AM GERIATR SOC, V34, P119, DOI 10.1111/j.1532-5415.1986.tb05480.x
   Trumic Edisa, 2012, Mater Sociomed, V24, P68, DOI 10.5455/msm.2012.24.68-72
   Walckiers D, 2015, ARCH PUBLIC HEALTH, V73, DOI 10.1186/s13690-015-0095-7
   Wastesson JW, 2016, J AM MED DIR ASSOC, V17, P31, DOI 10.1016/j.jamda.2015.07.015
   YESAVAGE JA, 1983, J PSYCHIATR RES, V17, P37, DOI 10.1016/0022-3956(82)90033-4
   Yuruyen M, 2016, KLIN PSIKOFARMAKOL B, V26, P374, DOI 10.5455/bcp.20160224101558
   Zahorec R, 2001, Bratisl Lek Listy, V102, P5
NR 66
TC 27
Z9 27
U1 0
U2 9
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-1998
J9 CLIN INTERV AGING
JI Clin. Interv. Aging
PY 2018
VL 13
BP 2003
EP 2011
DI 10.2147/CIA.S176329
PG 9
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA GX2CU
UT WOS:000447526900001
PM 30410317
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT S
AU Oxenkrug, GF
AF Oxenkrug, Gregory F.
BE Andrews, RJ
   Slikker, W
   Trembly, B
   Patterson, TA
TI Metabolic syndrome, age-associated neuroendocrine disorders, and
   dysregulation of tryptophan-kynurenine metabolism
SO NEUROPROTECTIVE AGENTS
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 9th International Conference on Neuroprotective Agents
CY SEP 07-11, 2008
CL Marine Biol Lab, Woods Hole, MA
HO Marine Biol Lab
DE metabolic syndrome; age-associated neuroendocrine disorders; tryptophan;
   kynurenine; cytokines; inflammation
ID NECROSIS-FACTOR-ALPHA; INDOLEAMINE 2,3-DIOXYGENASE ACTIVITY; SINGLE
   NUCLEOTIDE POLYMORPHISM; MAJOR DEPRESSIVE DISORDER; CHRONIC IMMUNE
   ACTIVATION; INTERFERON-GAMMA; IFN-GAMMA; N-ACETYLSEROTONIN; TNF-ALPHA;
   CARDIOVASCULAR RISK
AB The neuroendocrine theory of aging identified a cluster of conditions (hypertension, obesity, dyslipidemia, diabetes type 2, menopause, late onset depression, vascular cognitive impairment, impairment of immune defense, and some forms of cancer, e.g., breast and prostate) as age-associated neuroendocrine disorders (AAND). Obesity, dyslipidemia, hypertension, and type 2 diabetes were later described as metabolic syndromes (MetS). Chronic inflammation is currently considered as a common feature of MetS/AAND. One of the mechanisms by which chronic inflammation might trigger and/or maintain the development of MetS/AAND is transcriptional induction of indoleamine 2,3-dioxygenase (IDO), rate-limiting enzyme of tryptophan (TRY) kynurenine (KYN) pathway, by pro-inflammatory cytokines (PIC). Activation of IDO shifts TRY metabolism from serotonin synthesis to formation of "kynurenines." Diminished serotonin production is associated with mental depression while increased formation of Icynurenines might contribute to development of MetS/AAND via their apoptotic, neurotoxic, and pro-oxidative effects, and upregulation of inducible nitric oxide synthase, phospholipase A2, arachidonic acid, prostaglandin, 5-lipoxygenase, and leukotriene cascade. The combined presence of high producers of alleles of polymorphic PIG genes (e.g., interferon-gamma and tumor necrosis factor alpha) might account for the genetic predisposition to high levels of PIC production, leading to "superinduction" of IDO. The other rate-limiting enzyme of the TRY KYN pathway, TRY 2,3-dioxygenase, is activated by substrate (TRY) and cortisol. Therefore, KYN TRY metabolism might be the meeting point for gene-environment interaction and a new target for prevention and treatment of MetS/AAND.
C1 Tufts Univ, Sch Med, Dept Psychiat, Psychiat & Inflammat Program,Tufts Med Ctr, Boston, MA 02111 USA.
C3 Tufts Medical Center; Tufts University
RP Oxenkrug, GF (corresponding author), Tufts Univ, Sch Med, Dept Psychiat, Psychiat & Inflammat Program,Tufts Med Ctr, Boston, MA 02111 USA.
EM goxenkrug@tuftsmedicalcenter.org
OI Oxenkrug, Gregory/0000-0002-7193-9117
CR AlberatiGiani D, 1997, J IMMUNOL, V159, P419
   [Anonymous], HORMONES AGE CANC
   Bachurin S, 1999, ANN NY ACAD SCI, V890, P155, DOI 10.1111/j.1749-6632.1999.tb07990.x
   Baran H, 1996, LIFE SCI, V58, P1891, DOI 10.1016/0024-3205(96)00173-7
   Bergman MR, 1999, AM J PHYSIOL-HEART C, V277, pH543, DOI 10.1152/ajpheart.1999.277.2.H543
   Brandacher G, 2007, CURR DRUG METAB, V8, P289, DOI 10.2174/138920007780362590
   Brandacher G, 2006, OBES SURG, V16, P541, DOI 10.1381/096089206776945066
   Brustolim D, 2006, INT IMMUNOPHARMACOL, V6, P903, DOI 10.1016/j.intimp.2005.12.007
   Brzezinski A, 2005, SLEEP MED REV, V9, P41, DOI 10.1016/j.smrv.2004.06.004
   CADY SG, 1991, ARCH BIOCHEM BIOPHYS, V291, P326, DOI 10.1016/0003-9861(91)90142-6
   Carr MC, 2003, J CLIN ENDOCR METAB, V88, P2404, DOI 10.1210/jc.2003-030242
   CONNICK JH, 1989, J NEUROCHEM, V52, P985, DOI 10.1111/j.1471-4159.1989.tb02552.x
   Curzon G, 1996, ADV EXP MED BIOL, V398, P27
   Czerski PM, 2008, NEUROPSYCHOBIOLOGY, V57, P88, DOI 10.1159/000135642
   Dahlgren J, 2001, AM J PHYSIOL-ENDOC M, V281, pE326, DOI 10.1152/ajpendo.2001.281.2.E326
   Dang YH, 2000, FREE RADICAL BIO MED, V28, P615, DOI 10.1016/S0891-5849(99)00272-5
   de Luis DA, 2007, MED CLIN-BARCELONA, V129, P401, DOI 10.1157/13110463
   Deguchi K, 2001, MENOPAUSE, V8, P266, DOI 10.1097/00042192-200107000-00008
   Dilman V., 1979, Serotonin in Health and Diseases, V5, P111
   DILMAN VM, 1971, LANCET, V1, P1211
   DILMAN VM, 1954, THESIS LEINIGRAD RUS
   Dilman VM, 1994, Development, Aging and Disease: A New Rationale for an Intervention Strategy
   Dörffel Y, 1999, HYPERTENSION, V34, P113, DOI 10.1161/01.HYP.34.1.113
   Elias MF, 2003, INT J OBESITY, V27, P260, DOI 10.1038/sj.ijo.802225
   FINKELSTEIN JA, 1982, PHARMACOL BIOCHEM BE, V17, P939, DOI 10.1016/0091-3057(82)90476-2
   Franciotta D, 2006, NEUROSCI LETT, V395, P67, DOI 10.1016/j.neulet.2005.10.048
   Fulop T, 2006, PATHOL BIOL, V54, P375, DOI 10.1016/j.patbio.2006.07.002
   GAL EM, 1980, NEUROCHEM RES, V5, P223, DOI 10.1007/BF00964611
   Gonsky R, 2006, GENES IMMUN, V7, P342, DOI 10.1038/sj.gene.6364305
   GREEN AR, 1978, BRIT J CLIN PHARMACO, V5, P233, DOI 10.1111/j.1365-2125.1978.tb01630.x
   Hamer DH, 2009, J NUTR, V139, P113, DOI 10.3945/jn.108.095091
   Holvoet P, 2008, Verh K Acad Geneeskd Belg, V70, P193
   Janssen I, 2008, ARCH INTERN MED, V168, P1568, DOI 10.1001/archinte.168.14.1568
   Jawien Jacek, 2008, Pol Arch Med Wewn, V118, P127
   Jun TY, 2003, PSYCHIAT GENET, V13, P179, DOI 10.1097/00041444-200309000-00008
   Kamali-Sarvestani E, 2005, CANCER LETT, V223, P113, DOI 10.1016/j.canlet.2004.09.025
   Kawaguchi Rie, 2005, Nihon Rinsho Meneki Gakkai Kaishi, V28, P407
   Kenis G, 2002, INT J NEUROPSYCHOPH, V5, P401, DOI 10.1017/S1461145702003164
   Koga M, 2007, HYPERTENS RES, V30, P259, DOI 10.1291/hypres.30.259
   KOTAKE Y, 1975, ACTA VITAMINOL ENZYM, V29, P236
   KRYSTAL JH, 1994, ARCH GEN PSYCHIAT, V51, P199, DOI 10.1001/archpsyc.1994.03950030035004
   Kuc D, 2008, AMINO ACIDS, V35, P503, DOI 10.1007/s00726-007-0631-z
   Kwok JBJ, 2002, J BIOL CHEM, V277, P35779, DOI 10.1074/jbc.C200303200
   Lann D, 2007, MED CLIN N AM, V91, P1063, DOI 10.1016/j.mcna.2007.06.012
   Lapicque F, 1998, CLIN PHARMACOL THER, V63, P231
   Lapin IP, 1998, J PINEAL RES, V24, P215
   Lapin IP, 2003, ADV EXP MED BIOL, V527, P121
   LAPIN IP, 1978, PHARMACOL RES COMMUN, V10, P81, DOI 10.1016/S0031-6989(78)80065-4
   Lapin IP, 1996, ADV EXP MED BIOL, V398, P191
   LAPIN IP, 1969, LANCET, V1, P132
   Leonard BE, 2006, NEUROIMMUNOMODULAT, V13, P268, DOI 10.1159/000104854
   Liebau C, 2002, ANTICANCER RES, V22, P931
   Lio D, 2002, EXP GERONTOL, V37, P315, DOI 10.1016/S0531-5565(01)00198-X
   Manev H, 2007, ARCH GEN PSYCHIAT, V64, P1333, DOI 10.1001/archpsyc.64.11.1333
   Meier CA, 2007, B ACAD NAT MED PARIS, V191, P897, DOI 10.1016/S0001-4079(19)33028-6
   MELILLO G, 1994, J BIOL CHEM, V269, P8128
   Merete C, 2008, J AM COLL NUTR, V27, P421, DOI 10.1080/07315724.2008.10719720
   Mizutani K, 2002, HYPERTENS RES, V25, P135, DOI 10.1291/hypres.25.135
   Moreno MU, 2003, FEBS LETT, V542, P27, DOI 10.1016/S0014-5793(03)00331-4
   MOURSI GE, 1970, B WORLD HEALTH ORGAN, V43, P651
   Niinisalo P, 2008, SCAND J CLIN LAB INV, V68, P767, DOI 10.1080/00365510802245685
   Ordovas J, 2007, NUTR REV, V65, pS203, DOI [10.1111/j.1753-4887.2007.tb00363.x, 10.1301/nr.2007.dec.S203-S207]
   OXENKRUG GF, 1984, J PINEAL RES, V1, P181, DOI 10.1111/j.1600-079X.1984.tb00209.x
   Oxenkrug GF, 2003, CNS SPECTRUMS, V8, P139, DOI 10.1017/S109285290001837X
   OXENKRUG GF, 1983, PSYCHIAT RES, V10, P125, DOI 10.1016/0165-1781(83)90111-7
   OXENKRUG GF, 1984, BIOL PSYCHIAT, V19, P413
   OXENKRUG GF, 2010, ANN NY ACAD SCI, V1191, P114
   OXENKRUG GF, 1975, CHEM PHARM INDOLE CO, P5
   OXENKRUG GF, 2010, ISRAEL J PS IN PRESS
   Oxenkrug GF, 2007, ANN NY ACAD SCI, V1122, P35, DOI 10.1196/annals.1403.003
   Pacifico L, 2006, EUR J ENDOCRINOL, V154, P691, DOI 10.1530/eje.1.02138
   Pae CU, 2004, PSYCHIAT RES, V125, P65, DOI 10.1016/j.psychres.2003.06.002
   Pausova Z, 2003, HYPERTENSION, V41, P1047, DOI 10.1161/01.HYP.0000064347.49341.0B
   Penberthy WT, 2007, CURR DRUG METAB, V8, P245
   Perianayagam MC, 2005, ANN NY ACAD SCI, V1053, P386, DOI 10.1196/annals.1344.033
   Pertovaara M, 2007, CLIN EXP IMMUNOL, V148, P106, DOI 10.1111/j.1365-2249.2007.03325.x
   Pertovaara M, 2006, MECH AGEING DEV, V127, P497, DOI 10.1016/j.mad.2006.01.020
   Prakhie IV, 1998, INT J NEUROPSYCHOPH, V1, P35, DOI 10.1017/S1461145798001096
   Pravica V, 2000, HUM IMMUNOL, V61, P863, DOI 10.1016/S0198-8859(00)00167-1
   Raitala A, 2005, SCAND J IMMUNOL, V61, P387, DOI 10.1111/j.1365-3083.2005.01586.x
   Reddy AP, 2005, PSYCHOPHARMACOLOGY, V180, P125, DOI 10.1007/s00213-005-2154-1
   Requintina PJ, 2005, ANN NY ACAD SCI, V1053, P400, DOI 10.1196/annals.1344.035
   Requintina PJ, 2003, ANN NY ACAD SCI, V993, P325, DOI 10.1111/j.1749-6632.2003.tb07540.x
   Ridker PM, 2007, NUTR REV, V65, pS253, DOI 10.1301/nr.2007.dec.S253-S259
   Robinson CM, 2005, J INTERF CYTOK RES, V25, P20, DOI 10.1089/jir.2005.25.20
   Rocha VZ, 2008, CIRC RES, V103, P467, DOI 10.1161/CIRCRESAHA.108.177105
   Rodríguez MI, 2007, J PINEAL RES, V42, P272, DOI 10.1111/j.1600-079X.2006.00416.x
   Rongvaux A, 2003, BIOESSAYS, V25, P683, DOI 10.1002/bies.10297
   RUBIN RT, 1966, SCIENCE, V153, P767, DOI 10.1126/science.153.3737.767
   Ryu JK, 2006, NEUROSCIENCE, V141, P1835, DOI 10.1016/j.neuroscience.2006.05.043
   SAMSONOV.ML, 1972, VOP MED KHIM, V18, P198
   Schiepers OJG, 2005, PROG NEURO-PSYCHOPH, V29, P201, DOI 10.1016/j.pnpbp.2004.11.003
   SCHWARCZ R, J PHARM EXP THER, V303, P1
   Skurkovich B, 2006, E SCHERING RES FDN W, V56, P1
   Sookoian SC, 2005, OBES RES, V13, P2122, DOI 10.1038/oby.2005.263
   Stewart JC, 2007, ARCH GEN PSYCHIAT, V64, P225, DOI 10.1001/archpsyc.64.2.225
   Susa S, 2008, BIOCHEM BIOPH RES CO, V369, P943, DOI 10.1016/j.bbrc.2008.02.121
   Sutherland JP, 2004, METAB SYNDR RELAT D, V2, P82, DOI 10.1089/met.2004.2.82
   TAKIKAWA O, 1986, J BIOL CHEM, V261, P3648
   TAYLOR MW, 1991, FASEB J, V5, P2516, DOI 10.1096/fasebj.5.11.1907934
   Tsiavou A, 2005, CYTOKINE, V31, P135, DOI 10.1016/j.cyto.2005.02.011
   Walsh HA, 1997, J PINEAL RES, V23, P20, DOI 10.1111/j.1600-079X.1997.tb00330.x
   Wang JH, 2006, J BIOL CHEM, V281, P22021, DOI 10.1074/jbc.M603503200
   WILSON AG, 1993, J EXP MED, V177, P557, DOI 10.1084/jem.177.2.557
   Wirleitner B, 2003, EUR J CLIN INVEST, V33, P550, DOI 10.1046/j.1365-2362.2003.01186.x
   WOLF H, 1980, SCAND J CLIN LAB INV, V40, P15, DOI 10.3109/00365518009091522
   Wu HQ, 2007, J NEURAL TRANSM, V114, P33, DOI 10.1007/s00702-006-0562-y
   You TJ, 2008, J GERONTOL A-BIOL, V63, P414, DOI 10.1093/gerona/63.4.414
   Zarate CA, 2005, BIOL PSYCHIAT, V57, P430, DOI 10.1016/j.biopsych.2004.11.023
   Zawilska JB, 1997, POL J PHARMACOL, V49, P479
   Zhang Yi, 2005, Zhonghua Xinxueguanbing Zazhi, V33, P588
NR 111
TC 181
Z9 195
U1 0
U2 35
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA
SN 0077-8923
BN 978-1-57331-777-1
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2010
VL 1199
BP 1
EP 14
DI 10.1111/j.1749-6632.2009.05356.x
PG 14
WC Multidisciplinary Sciences; Neurosciences
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics; Neurosciences & Neurology
GA BRJ59
UT WOS:000282838900001
PM 20633104
DA 2025-06-11
ER

PT J
AU Najafi, N
   Mehri, S
   Rahbardar, MG
   Hosseinzadeh, H
AF Najafi, Nahid
   Mehri, Soghra
   Ghasemzadeh Rahbardar, Mahboobeh
   Hosseinzadeh, Hossein
TI Effects of alpha lipoic acid on metabolic syndrome: A comprehensive
   review
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE alpha-lipoic acid; diabetes; dyslipidemia; hypertension; metabolic
   syndrome; obesity
ID TYPE-2 DIABETES-MELLITUS; INSULIN-AUTOIMMUNE-SYNDROME; SALT-INDUCED
   HYPERTENSION; ACTIVATED PROTEIN-KINASE; GAMMA-LINOLENIC ACID;
   ACETYL-L-CARNITINE; E-DEFICIENT MICE; OXIDATIVE STRESS; ENDOTHELIAL
   DYSFUNCTION; ANTIOXIDANT STATUS
AB Metabolic syndrome (MetS) is a multifactorial disease with medical conditions such as hypertension, diabetes, obesity, dyslipidemia, and insulin resistance. Alpha-lipoic acid (alpha-LA) possesses various pharmacological effects, including antidiabetic, antiobesity, hypotensive, and hypolipidemia actions. It exhibits reactive oxygen species scavenger properties against oxidation and age-related inflammation and refines MetS components. Also, alpha-LA activates the 5 ' adenosine monophosphate-activated protein kinase and inhibits the NF kappa b. It can decrease cholesterol biosynthesis, fatty acid beta-oxidation, and vascular stiffness. alpha-LA decreases lipogenesis, cholesterol biosynthesis, low-density lipoprotein and very low-density lipoprotein levels, and atherosclerosis. Moreover, alpha-LA increases insulin secretion, glucose transport, and insulin sensitivity. These changes occur via PI3K/Akt activation. On the other hand, alpha-LA treats central obesity by increasing adiponectin levels and mitochondrial biogenesis and can reduce food intake mainly by SIRT1 stimulation. In this review, the most relevant articles have been discussed to determine the effects of alpha-LA on different components of MetS with a special focus on different molecular mechanisms behind these effects. This review exhibits the potential properties of alpha-LA in managing MetS; however, high-quality studies are needed to confirm the clinical efficacy of alpha-LA.
C1 [Najafi, Nahid] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Razavi Khorasan, Iran.
   [Najafi, Nahid; Mehri, Soghra; Ghasemzadeh Rahbardar, Mahboobeh; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.
   [Mehri, Soghra; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran.
EM hosseinzadehh@mums.ac.ir
RI mehri, soghra/P-2939-2018; Ghasemzadeh Rahbardar, Mahboobeh/V-4452-2019;
   Hosseinzadeh, Hossein/F-3013-2010
OI Ghasemzadeh Rahbardar, Mahboobeh/0000-0002-5491-572X; Hosseinzadeh,
   Hossein/0000-0002-3483-851X
CR Abd-Ellah HF, 2017, ULTRASTRUCT PATHOL, V41, P196, DOI 10.1080/01913123.2017.1286422
   Akbari M, 2018, NUTR METAB, V15, DOI 10.1186/s12986-018-0274-y
   Amirkhizi F, 2018, IRAN RED CRESCENT ME, V20, DOI 10.5812/ircmj.65925
   Amom Z, 2008, J CLIN BIOCHEM NUTR, V43, P88, DOI 10.3164/jcbn.2008051
   Amudha G, 2007, MOL CELL BIOCHEM, V301, P165, DOI 10.1007/s11010-006-9408-z
   Anber H., 2020, INDIAN J PUBLIC HLTH, V11, P1213
   Ansar H, 2011, SAUDI MED J, V32, P584
   Aslfalah H, 2019, J OBSTET GYNAECOL RE, V45, P313, DOI 10.1111/jog.13842
   Aslfalah H, 2019, GYNECOL ENDOCRINOL, V35, P271, DOI 10.1080/09513590.2018.1519795
   Atmaca HU, 2017, ACTA ENDOCRINOL-BUCH, V13, P461, DOI 10.4183/aeb.2017.461
   Bae SM, 2013, ENDOCRINOL METAB, V28, P326, DOI 10.3803/EnM.2013.28.4.326
   Baldini N, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20010126
   Banji D., 2011, INT J PHARM SCI RES, V2, P124
   Bierhaus A, 1997, DIABETES, V46, P1481, DOI 10.2337/diab.46.9.1481
   Bilska A, 2007, NEUROSCIENCE, V146, P1758, DOI 10.1016/j.neuroscience.2007.04.002
   Bitar MS, 2004, HORM METAB RES, V36, P542, DOI 10.1055/s-2004-825760
   Black K, 1998, CLIN EXP PHARMACOL P, V25, P712, DOI 10.1111/j.1440-1681.1998.tb02281.x
   Bo S, 2004, ACTA OBSTET GYN SCAN, V83, P335, DOI 10.1111/j.0001-6349.2004.00314.x
   Bresciani Enrico, 2011, Diabetes Care, V34, pe146, DOI 10.2337/dc11-0600
   Budin SB, 2007, MALAYS J MED SCI, V14, P47
   Cao XH, 2006, PHARM RES, V23, P1675, DOI 10.1007/s11095-006-9041-2
   Capasso I, 2013, TRIALS, V14, DOI 10.1186/1745-6215-14-273
   Carbonelli MG, 2010, CURR PHARM DESIGN, V16, P840, DOI 10.2174/138161210790883589
   Carrier B, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0090863
   Cerf Marlon E, 2013, Front Endocrinol (Lausanne), V4, P37, DOI 10.3389/fendo.2013.00037
   Chen WL, 2012, DIABETOLOGIA, V55, P1824, DOI 10.1007/s00125-012-2530-4
   Chen Xie-sheng, 2009, Nan Fang Yi Ke Da Xue Xue Bao, V29, P704
   Cheng PY, 2012, AM J HYPERTENS, V25, P152, DOI 10.1038/ajh.2011.196
   Chiou WL, 2000, PHARMACEUT RES, V17, P135, DOI 10.1023/A:1007552927404
   Chiou WL, 2002, PHARMACEUT RES, V19, P868, DOI 10.1023/A:1016169202830
   Cremer DR, 2006, REGUL TOXICOL PHARM, V46, P29, DOI 10.1016/j.yrtph.2006.06.004
   Cronan JE, 2020, FRONT GENET, V11, DOI 10.3389/fgene.2020.00510
   Cummings BP, 2010, AM J PHYSIOL-REG I, V298, pR1343, DOI 10.1152/ajpregu.00468.2009
   De Lange-Jacobs P, 2020, MOLECULES, V25, DOI 10.3390/molecules25092114
   de Oliveira AM, 2011, DIABETES RES CLIN PR, V92, P253, DOI 10.1016/j.diabres.2011.02.010
   de Queiroz TM, 2015, AM J PHYSIOL-HEART C, V309, pH926, DOI 10.1152/ajpheart.00259.2015
   Duvnjak Lea, 2008, Diabetologia Croatica, V37, P83
   Eisvand F, 2020, PHYTOTHER RES, V34, P1798, DOI 10.1002/ptr.6646
   El Midaoui A, 2002, HYPERTENSION, V39, P303, DOI 10.1161/hy0202.104345
   El Midaoui A, 2007, DIABETES, V56, pA193
   El Midaoui A, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8120648
   Ergur BU, 2015, ANATOL J CARDIOL, V15, P443, DOI 10.5152/akd.2014.5483
   Esmaeilzadeh D, 2020, PHYTOTHER RES, V34, P2192, DOI 10.1002/ptr.6679
   Fadishei M, 2021, PHYTOTHER RES, V35, P2005, DOI 10.1002/ptr.6944
   Fernández-Galilea M, 2015, BBA-MOL CELL BIOL L, V1851, P273, DOI 10.1016/j.bbalip.2014.12.013
   Fernández-Galilea M, 2014, OBESITY, V22, P2210, DOI 10.1002/oby.20846
   Fonseca Vivian A, 2005, Clin Cornerstone, V7, P61, DOI 10.1016/S1098-3597(05)80069-9
   Furukawa N, 2007, DIABETES RES CLIN PR, V75, P366, DOI 10.1016/j.diabres.2006.07.005
   Gatti M, 2021, CLIN NUTR, V40, P1176, DOI 10.1016/j.clnu.2020.07.028
   Genazzani AD, 2019, GYNECOL ENDOCRINOL, V35, P1088, DOI 10.1080/09513590.2019.1640200
   Ghelani H, 2017, PHARMACOL RES PERSPE, V5, DOI 10.1002/prp2.306
   Gomes MB, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-80
   Goraça A, 2011, PHARMACOL REP, V63, P849
   Gossetin LE, 2019, FOOD FUNCT, V10, P5732, DOI [10.1039/C9FO00390H, 10.1039/c9fo00390h]
   Gotoda Takanari, 2004, Nihon Rinsho, V62, P1037
   Greene EL, 2001, METABOLISM, V50, P1063, DOI 10.1053/meta.2001.25601
   Gruzman A, 2004, BIOORGAN MED CHEM, V12, P1183, DOI 10.1016/j.bmc.2003.11.025
   Gullo D, 2014, CLIN ENDOCRINOL, V81, P204, DOI 10.1111/cen.12334
   Haghighatdoost F, 2020, EUR J CLIN PHARMACOL, V76, P649, DOI 10.1007/s00228-020-02844-w
   Hahm JR, 2014, LIFE SCI, V100, P125, DOI 10.1016/j.lfs.2014.02.001
   Han TS, 2016, JRSM CARDIOVASC DIS, V5, DOI 10.1177/2048004016633371
   Hassani FV, 2016, N-S ARCH PHARMACOL, V389, P931, DOI 10.1007/s00210-016-1256-0
   Hejazi Najmeh, 2018, Asian J Anesthesiol, V56, P45, DOI 10.6859/aja.201806_56(2).0002
   Henriksen EJ, 1997, LIFE SCI, V61, P805, DOI 10.1016/S0024-3205(97)00562-6
   Hosseini A, 2015, J ENDOCRINOL INVEST, V38, P1147, DOI 10.1007/s40618-015-0313-8
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Huang T, 2006, PROTEIN PEPTIDE LETT, V13, P135, DOI 10.2174/092986606775101599
   Huang Yong-di, 2011, Zhonghua Liu Xing Bing Xue Za Zhi, V32, P290
   Huang ZM, 2013, DIABETES TECHNOL THE, V15, P859, DOI 10.1089/dia.2013.0013
   Huerta AE, 2017, J FUNCT FOODS, V36, P178, DOI 10.1016/j.jff.2017.07.002
   Huerta AE, 2017, BIOFACTORS, V43, P117, DOI 10.1002/biof.1317
   Huerta AE, 2016, J NUTR, V146, p889S, DOI 10.3945/jn.115.224105
   Huerta AE, 2015, OBESITY, V23, P313, DOI 10.1002/oby.20966
   Ibrahimpasic Kanita, 2013, Med Arch, V67, P7
   Ishida Y, 2007, DIABETES CARE, V30, P2240, DOI 10.2337/dc07-0689
   Izzo AA, 2016, PHYTOTHER RES, V30, P691, DOI 10.1002/ptr.5591
   JACOB S, 1995, ARZNEIMITTEL-FORSCH, V45-2, P872
   Jacob S, 1999, BIOFACTORS, V10, P169, DOI 10.1002/biof.5520100212
   Jacob S, 1996, EXP CLIN ENDOCR DIAB, V104, P284, DOI 10.1055/s-0029-1211455
   Jacob S, 1999, FREE RADICAL BIO MED, V27, P309, DOI 10.1016/S0891-5849(99)00089-1
   Jacob S, 1996, DIABETES, V45, P1024, DOI 10.2337/diabetes.45.8.1024
   Jamor P., 2018, J NEPHROPATHOL, V7, P241, DOI [10.15171/jnp.2018.49, DOI 10.15171/JNP.2018.49]
   Jang A, 2014, FOOD FUNCT, V5, P1966, DOI [10.1039/c4fo00246f, 10.1039/C4FO00246F]
   Jia R, 2014, POULTRY SCI, V93, P2809, DOI 10.3382/ps.2014-03921
   Kamenova Petya, 2006, Hormones (Athens), V5, P251
   Karkabounas S, 2018, J MED FOOD, V21, P1197, DOI 10.1089/jmf.2018.0007
   Kawamoto R, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-79
   Khamaisi M, 1999, ANTIOXID REDOX SIGN, V1, P523, DOI 10.1089/ars.1999.1.4-523
   Kim E, 2008, J CLIN PSYCHOPHARM, V28, P138, DOI 10.1097/JCP.0b013e31816777f7
   Kim H, 2014, PSYCHOPHARMACOLOGY, V231, P4059, DOI 10.1007/s00213-014-3540-3
   Kim MS, 2004, NAT MED, V10, P727, DOI 10.1038/nm1061
   Koçak G, 2000, DIABETES NUTR METAB, V13, P308
   Konrad T, 1999, DIABETES CARE, V22, P280, DOI 10.2337/diacare.22.2.280
   Kuo YT, 2012, EUR J PHARMACOL, V692, P10, DOI 10.1016/j.ejphar.2012.07.028
   Lahera V, 2017, CURR HYPERTENS REP, V19, DOI 10.1007/s11906-017-0710-9
   Lee Byung Wan, 2009, Free Radic Res, V43, P68, DOI 10.1080/10715760802590400
   Lee WR, 2012, MOL BIOL REP, V39, P6857, DOI 10.1007/s11033-012-1511-5
   Li CJ, 2009, CHINESE MED J-PEKING, V122, P2580, DOI 10.3760/cma.j.issn.0366-6999.2009.21.010
   Liu YX, 2011, PHARMACOL REP, V63, P1180, DOI 10.1016/S1734-1140(11)70637-5
   Lukaszuk J.M., 2009, J COMPLEMENTARY INTE, V6, P1297, DOI 10.2202/1553-3840.1297
   Ma A, 2017, J LIPID RES, V58, P1536, DOI 10.1194/jlr.M073270
   Mahdian D, 2020, IRAN J BASIC MED SCI, V23, P1374, DOI 10.22038/ijbms.2020.42115.9957
   Malekzadeh S, 2019, IRAN J BASIC MED SCI, V22, P1476, DOI [10.22038/IJBMS.2019.13992, 10.22038/ijbms.2019.13992]
   Manning PJ, 2013, NUTR METAB CARDIOVAS, V23, P543, DOI 10.1016/j.numecd.2011.11.006
   McMackin Craig J, 2007, J Clin Hypertens (Greenwich), V9, P249
   McNeilly AM, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-217
   Miao YL, 2013, INT J MOL MED, V32, P1179, DOI 10.3892/ijmm.2013.1482
   Mignini F., 2012, J CLIN CELL IMMUNOL, V1, P418, DOI DOI 10.4172/SCIENTIFICREPORTS.418
   Mihailovic M, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10030480
   Moffa S, 2019, NUTRITION, V57, P1, DOI 10.1016/j.nut.2018.04.010
   Mohammadi V, 2017, IRAN RED CRESCENT ME, V19, DOI 10.5812/ircmj.58765
   Mohammadi V, 2017, J RES MED SCI, V22, DOI 10.4103/jrms.JRMS_1_17
   Mohammed MA, 2019, STEROIDS, V144, P1, DOI 10.1016/j.steroids.2019.01.004
   Moini H, 2002, ARCH BIOCHEM BIOPHYS, V397, P384, DOI 10.1006/abbi.2001.2680
   Mollazadeh H, 2019, PHYTOMEDICINE, V53, P43, DOI 10.1016/j.phymed.2018.09.024
   Molz P, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00849
   Morakinyo A. O., 2013, Biology and Medicine, V5, P26
   Muellenbach EA, 2008, METABOLISM, V57, P1465, DOI 10.1016/j.metabol.2008.05.018
   Muellenbach EM, 2009, LIFE SCI, V84, P563, DOI 10.1016/j.lfs.2009.01.021
   Musther H, 2014, EUR J PHARM SCI, V57, P280, DOI 10.1016/j.ejps.2013.08.018
   Mythili Y, 2006, EUR J PHARMACOL, V543, P92, DOI 10.1016/j.ejphar.2006.06.007
   Naito Y, 2014, J CLIN BIOCHEM NUTR, V55, P97, DOI 10.3164/jcbn.14-56
   Najmi A, 2008, INT J DIABETES DEV C, V28, P11, DOI 10.4103/0973-3930.41980
   Nguyen H., 2022, STATPEARLS
   Nyakudya TT, 2020, MOLECULES, V25, DOI 10.3390/molecules25112669
   Obrosova I, 1998, DIABETOLOGIA, V41, P1442, DOI 10.1007/s001250051090
   Okanovic Azra, 2015, Med Glas (Zenica), V12, P122, DOI 10.17392/798-15
   Olefsky JM, 2010, ANNU REV PHYSIOL, V72, P219, DOI 10.1146/annurev-physiol-021909-135846
   Ong SLH, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/517045
   OU PM, 1995, BIOCHEM PHARMACOL, V50, P123, DOI 10.1016/0006-2952(95)00116-H
   Özdogan S, 2012, J CLIN BIOCHEM NUTR, V50, P145, DOI 10.3164/jcbn.11-47
   Pace C, 2017, TOXICS, V5, DOI 10.3390/toxics5040038
   Panda P., 2017, ASIAN J PHARM CLIN R, V10, P204, DOI [10.22159/ajpcr.2017.v10i8.18869, DOI 10.22159/AJPCR.2017.V10I8.18869]
   Panzhinskiy E, 2019, J AM COLL NUTR, V38, P493, DOI 10.1080/07315724.2018.1557572
   Patel J, 2011, EVID-BASED COMPL ALT, V2011, DOI 10.1155/2011/120801
   Patil AS, 2020, BIOMED PHARMACOTHER, V132, DOI 10.1016/j.biopha.2020.110889
   Peth JA, 2000, AM J PHYSIOL-REG I, V278, pR453, DOI 10.1152/ajpregu.2000.278.2.R453
   Poppitt SD, 2008, NUTRITION, V24, P322, DOI 10.1016/j.nut.2007.12.012
   Porasuphatana S, 2012, ASIA PAC J CLIN NUTR, V21, P12
   Pradhan S, 2014, INT J PHARM SCI REV, V29, P62
   Qin ZY, 2012, J BIOENERG BIOMEMBR, V44, P579, DOI 10.1007/s10863-012-9460-1
   Queiroz TM, 2012, MOLECULES, V17, P13357, DOI 10.3390/molecules171113357
   Rahimi VB, 2021, PHYTOTHER RES, V35, P3558, DOI 10.1002/ptr.7046
   Rahmanabadi A, 2019, FOOD FUNCT, V10, P4941, DOI [10.1039/C9FO00449A, 10.1039/c9fo00449a]
   Rideout Todd C., 2016, Journal of Dietary Supplements, V13, P283, DOI 10.3109/19390211.2015.1008616
   Roberts JL, 2016, BBA-MOL CELL BIOL L, V1861, P166, DOI 10.1016/j.bbalip.2015.12.001
   Romo-Hualde A, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0750-4
   Ross Stephanie Maxine, 2006, Holist Nurs Pract, V20, P305
   Ruderman NB, 2010, AM J PHYSIOL-ENDOC M, V298, pE751, DOI 10.1152/ajpendo.00745.2009
   Saengsirisuwan V, 2004, AM J PHYSIOL-ENDOC M, V287, pE529, DOI 10.1152/ajpendo.00013.2004
   Salehi B, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9080356
   Sanati S, 2018, IRAN J BASIC MED SCI, V21, P439, DOI 10.22038/IJBMS.2018.25200.6238
   Satyanarayana S., 2006, THERAPY, V3, P613, DOI [10.1586/14750708.3.5.613, DOI 10.1586/14750708.3.5.613]
   Sena CM, 2008, BRIT J PHARMACOL, V153, P894, DOI 10.1038/sj.bjp.0707474
   Seo EY, 2012, NUTR RES PRACT, V6, P195, DOI 10.4162/nrp.2012.6.3.195
   Serhiyenko VA, 2013, ZH NEVROL PSIKHIATR, V113, P54
   Shay KP, 2009, BBA-GEN SUBJECTS, V1790, P1149, DOI 10.1016/j.bbagen.2009.07.026
   Shen DC, 2018, CELL PHYSIOL BIOCHEM, V47, P2261, DOI 10.1159/000491537
   Shen W, 2008, J CELL BIOCHEM, V104, P1232, DOI 10.1002/jcb.21701
   Singh U, 2008, NUTR REV, V66, P646, DOI 10.1111/j.1753-4887.2008.00118.x
   Skibska B, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/313021
   Sola S, 2005, CIRCULATION, V111, P343, DOI 10.1161/01.CIR.0000153272.48711.B9
   Song KH, 2005, BIOCHEM BIOPH RES CO, V326, P197, DOI 10.1016/j.bbrc.2004.10.213
   Spahis S, 2017, ANTIOXID REDOX SIGN, V26, P445, DOI 10.1089/ars.2016.6756
   Stump CS, 2006, ANN MED, V38, P389, DOI 10.1080/07853890600888413
   Tabeshpour J, 2017, IRAN J BASIC MED SCI, V20, P557, DOI 10.22038/IJBMS.2017.8682
   Takaoka M, 2001, EUR J PHARMACOL, V424, P121, DOI 10.1016/S0014-2999(01)01120-7
   Takeuchi Y, 2007, INTERNAL MED, V46, P237, DOI 10.2169/internalmedicine.46.1893
   Targonsky ED, 2006, DIABETOLOGIA, V49, P1587, DOI 10.1007/s00125-006-0265-9
   Teta M, 2007, DEV CELL, V12, P817, DOI 10.1016/j.devcel.2007.04.011
   Thaakur S., 2008, PHARMACOLOGY, V2, P493
   Thirunavukkarasu V, 2004, NUTR METAB CARDIOVAS, V14, P351, DOI 10.1016/S0939-4753(04)80025-5
   Thirunavukkarasu V, 2004, EXP DIABESITY RES, V5, P195, DOI 10.1080/15438600490486778
   Thirunavukkarasu V, 2004, DIABETES OBES METAB, V6, P200, DOI 10.1111/j.1462-8902.2004.00332.x
   Tibullo D, 2017, INFLAMM RES, V66, P947, DOI 10.1007/s00011-017-1079-6
   Topsakal S, 2016, PANCREATOLOGY, V16, P347, DOI 10.1016/j.pan.2016.03.001
   Tromba L, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020375
   Uchendu C, 2018, ENVIRON SCI POLLUT R, V25, P19605, DOI 10.1007/s11356-018-2185-x
   Udupa A, 2013, ANN MED HEALTH SCI R, V3, P442, DOI 10.4103/2141-9248.117954
   Vajdi M, 2020, INT J CLIN PRACT, V74, DOI 10.1111/ijcp.13493
   Vasdev S, 2000, CLIN CHEM, V46, pA138
   Vasdev S, 2003, MOL CELL BIOCHEM, V254, P319, DOI 10.1023/A:1027354005498
   Veltroni A, 2018, ENDOCRINOL DIAB META, DOI 10.1530/EDM-18-0011
   Veresiu IA, 2009, ACTA ENDOCRINOL, V5, P501, DOI 10.4183/aeb.2009.501
   Vidovic B, 2017, J MED FOOD, V20, P79, DOI 10.1089/jmf.2016.0070
   Vona R, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8267234
   Wang YM, 2012, J BIOENERG BIOMEMBR, V44, P357, DOI 10.1007/s10863-012-9440-5
   Wang YF, 2017, COMP BIOCHEM PHYS A, V211, P34, DOI 10.1016/j.cbpa.2017.06.005
   Weinstein RB, 2001, FREE RADICAL BIO MED, V30, P383, DOI 10.1016/S0891-5849(00)00489-5
   Wollin SD, 2004, J NUTR BIOCHEM, V15, P402, DOI 10.1016/j.jnutbio.2003.12.001
   Xiang GD, 2008, CLIN ENDOCRINOL, V68, P716, DOI 10.1111/j.1365-2265.2007.03099.x
   Xiang GD, 2011, METABOLISM, V60, P480, DOI 10.1016/j.metabol.2010.04.011
   Xu JQ, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-148
   Yang Y, 2014, ACTA PHARMACOL SIN, V35, P1285, DOI 10.1038/aps.2014.64
   Yang Y, 2012, DEV GROWTH DIFFER, V54, P557, DOI 10.1111/j.1440-169X.2012.01356.x
   Yapar SB, 2014, TURK J BIOCHEM, V39, P317, DOI 10.5505/tjb.2014.71501
   Yarmohammadi F, 2021, IRAN J BASIC MED SCI, V24, P420, DOI 10.22038/ijbms.2021.50276.11452
   Yasuno R, 1998, PLANT PHYSIOL, V118, P935, DOI 10.1104/pp.118.3.935
   Yi XW, 2006, DIABETES, V55, P2238, DOI 10.2337/db06-0251
   Yi XW, 2012, ATHEROSCLEROSIS, V223, P137, DOI 10.1016/j.atherosclerosis.2012.04.025
   Yi XW, 2011, J DIABETES COMPLICAT, V25, P193, DOI 10.1016/j.jdiacomp.2010.07.004
   Yi XH, 2013, BIOCHEM BIOPH RES CO, V439, P390, DOI 10.1016/j.bbrc.2013.08.063
   Zhao F, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.690521
   Zulkhairi A, 2008, BIOMED PHARMACOTHER, V62, P716, DOI 10.1016/j.biopha.2006.12.003
NR 204
TC 37
Z9 40
U1 4
U2 44
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD JUN
PY 2022
VL 36
IS 6
BP 2300
EP 2323
DI 10.1002/ptr.7406
EA MAR 2022
PG 24
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 2E6PJ
UT WOS:000762849500001
PM 35234312
DA 2025-06-11
ER

PT J
AU Merkus, D
   Muller-Delp, J
   Heaps, CL
AF Merkus, Daphne
   Muller-Delp, Judy
   Heaps, Cristine L.
TI Coronary microvascular adaptations distal to epicardial artery stenosis
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Review
DE collaterals; diabetes; exercise training; metabolic syndrome
ID INTENSIVE PHYSICAL-EXERCISE; CHRONIC MYOCARDIAL-ISCHEMIA; FIBROBLAST
   GROWTH FACTOR-2; NECROSIS-FACTOR-ALPHA; BYPASS GRAFT-SURGERY; COLLATERAL
   DEVELOPMENT; SWINE MODEL; METABOLIC SYNDROME; OXIDATIVE STRESS; PORCINE
   MODEL
AB Until recently, epicardial coronary stenosis has been considered the primary outcome of coronary heart disease, and clinical interventions have been dedicated primarily to the identification and removal of flow-limiting stenoses. However, a growing body of literature indicates that both epicardial stenosis and microvascular dysfunction contribute to damaging myocardial ischemia. In this review, we discuss the coexistence of macro- and microvascular disease, and how the structure and function of the distal microcirculation is impacted by the hemodynamic consequences of an epicardial, flow-limiting stenosis. Mechanisms of endothelial dysfunction as well as alterations of smooth muscle function in the coronary microcirculation distal to stenosis are discussed. Risk factors including diabetes, metabolic syndrome, and aging exacerbate microvascular dysfunction in the myocardium distal to a stenosis, and our current understanding of the role of these factors in limiting collateralization and angiogenesis of the ischemic myocardium is presented. Importantly, exercise training has been shown to promote collateral growth and improve microvascular function distal to stenosis; thus, the current literature reporting the mechanisms that underlie the beneficial effects of exercise training in the microcirculation distal to epicardial stenosis is reviewed. We also discuss recent studies of therapeutic interventions designed to improve microvascular function and stimulate angiogenesis in clinically relevant animal models of epicardial stenosis and microvascular disease. Finally, microvascular adaptation to removal of epicardial stenosis is considered.
C1 [Merkus, Daphne] Ludwig Maximilians Univ Munchen, Walter Brendel Ctr Expt Med WBex, Inst Surg Res, Univ Clin, Munich, Germany.
   [Merkus, Daphne] Munich Heart Alliance MHA, German Ctr Cardiovasc Res DZHK, Munich, Germany.
   [Merkus, Daphne] Univ Med Ctr, Dept Cardiol, Erasmus MC, Rotterdam, Netherlands.
   [Muller-Delp, Judy] Florida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL USA.
   [Heaps, Cristine L.] Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Physiol & Pharmacol, College Stn, TX 77843 USA.
   [Heaps, Cristine L.] Texas A&M Univ, Coll Vet Med & Biomed Sci, Michael E DeBakey Inst Comparat Cardiovasc Sci &, College Stn, TX 77843 USA.
C3 University of Munich; German Centre for Cardiovascular Research; Erasmus
   University Rotterdam; Erasmus MC; State University System of Florida;
   Florida State University; Texas A&M University System; Texas A&M
   University College Station; Texas A&M University System; Texas A&M
   University College Station
RP Heaps, CL (corresponding author), Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Physiol & Pharmacol, College Stn, TX 77843 USA.; Heaps, CL (corresponding author), Texas A&M Univ, Coll Vet Med & Biomed Sci, Michael E DeBakey Inst Comparat Cardiovasc Sci &, College Stn, TX 77843 USA.
EM cheaps@cvm.tamu.edu
RI Delp, Judy/F-4303-2016; Merkus, Daphne/AAN-4459-2020
OI Merkus, Daphne/0000-0002-4852-831X; Muller-Delp,
   Judy/0000-0001-5322-0611
FU National Heart, Lung, and Blood Institute [HL139903]; German Center for
   Cardiovascular Research (DZHK) [81Z0600207]; Dutch Cardiovascular
   Alliance (DCVA-Reconnext); National Heart Lung and Blood Institute
   [R01HL139903] Funding Source: NIH RePORTER
FX This work was funded by National Heart, Lung, and Blood Institute Grant
   HL139903 (to C. L. Heaps), German Center for Cardiovascular Research
   (DZHK) Grant 81Z0600207 (to D. Merkus), and Dutch Cardiovascular
   Alliance (DCVA-Reconnext) (to D. Merkus).
CR Abdel-Aty H, 2009, J AM COLL CARDIOL, V53, P1194, DOI 10.1016/j.jacc.2008.10.065
   Arras M, 1998, BASIC RES CARDIOL, V93, P97, DOI 10.1007/s003950050069
   BACHE RJ, 1983, AM J PHYSIOL, V245, pH131, DOI 10.1152/ajpheart.1983.245.1.H131
   Bagi Z, 2003, AM J PHYSIOL-HEART C, V285, pH1404, DOI 10.1152/ajpheart.00235.2003
   Bates DO, 2002, VASC PHARMACOL, V39, P225, DOI 10.1016/S1537-1891(03)00011-9
   Baur JA, 2006, NAT REV DRUG DISCOV, V5, P493, DOI 10.1038/nrd2060
   Belardinelli R, 1998, CIRCULATION, V97, P553
   Belardinelli R, 2001, EUR HEART J, V22, P1205, DOI 10.1053/euhj.2000.2446
   Benjamin EJ, 2018, CIRCULATION, V137, pE67, DOI [10.1161/CIR.0000000000000485, 10.1161/CIR.0000000000000558, 10.1161/CIR.0000000000000530]
   Bhui R, 2017, PLOS COMPUT BIOL, V13, DOI 10.1371/journal.pcbi.1005523
   Bikou O, 2019, FRONT CARDIOVASC MED, V6, DOI 10.3389/fcvm.2019.00157
   BLOOR CM, 1984, J APPL PHYSIOL, V56, P656, DOI 10.1152/jappl.1984.56.3.656
   Boodhwani M, 2006, ANN THORAC SURG, V81, P634, DOI 10.1016/j.athoracsur.2005.07.090
   Boodhwani M, 2007, CIRCULATION, V116, pI31, DOI 10.1161/CIRCULATIONAHA.106.680157
   Boodhwani M, 2006, CIRCULATION, V114, pI402, DOI 10.1161/CIRCULATIONAHA.105.000356
   Bosch-Marce M, 2007, CIRC RES, V101, P1310, DOI 10.1161/CIRCRESAHA.107.153346
   Britten MB, 2004, CORONARY ARTERY DIS, V15, P259, DOI 10.1097/01.mca.0000134590.99841.81
   Caceres VHU, 2011, AM J PHYSIOL-HEART C, V300, pH693, DOI 10.1152/ajpheart.00516.2010
   Chamuleau SAJ, 2003, AM J PHYSIOL-HEART C, V285, pH2194, DOI 10.1152/ajpheart.01021.2002
   CHILIAN WM, 1990, AM J PHYSIOL, V258, pH529, DOI 10.1152/ajpheart.1990.258.2.H529
   CHILIAN WM, 1989, AM J PHYSIOL, V256, pH383, DOI 10.1152/ajpheart.1989.256.2.H383
   CHILIAN WM, 1986, AM J PHYSIOL, V251, pH779, DOI 10.1152/ajpheart.1986.251.4.H779
   COHEN MV, 1981, AM J PHYSIOL, V240, pH811, DOI 10.1152/ajpheart.1981.240.5.H811
   COHEN MV, 1982, J APPL PHYSIOL, V52, P664, DOI 10.1152/jappl.1982.52.3.664
   Cohen MV, 1985, Coronary Collaterals: Clinical and Experimental Observation, P93
   Csiszar A, 2004, PHYSIOL GENOMICS, V17, P21, DOI 10.1152/physiolgenomics.00136.2003
   Csiszar A, 2002, CIRC RES, V90, P1159, DOI 10.1161/01.RES.0000020401.61826.EA
   de Beer VJ, 2011, AM J PHYSIOL-HEART C, V300, pH1950, DOI 10.1152/ajpheart.00954.2010
   De Bruyne B, 2017, CIRC-CARDIOVASC INTE, V10, DOI 10.1161/CIRCINTERVENTIONS.116.004719
   de Waard GA, 2020, ARTERIOSCL THROM VAS, V40, P230, DOI 10.1161/ATVBAHA.119.313462
   Dhawan SS, 2011, ATHEROSCLEROSIS, V219, P266, DOI 10.1016/j.atherosclerosis.2011.05.020
   Dongaonkar RM, 2010, CARDIOVASC RES, V87, P331, DOI 10.1093/cvr/cvq145
   Dörge H, 2000, AM J PHYSIOL-HEART C, V279, pH2587, DOI 10.1152/ajpheart.2000.279.6.H2587
   Duncker DJ, 2015, PROG CARDIOVASC DIS, V57, P409, DOI 10.1016/j.pcad.2014.12.002
   ECKSTEIN RW, 1957, CIRC RES, V5, P230, DOI 10.1161/01.RES.5.3.230
   Elmadhun NY, 2014, J THORAC CARDIOV SUR, V148, P1048, DOI 10.1016/j.jtcvs.2014.05.056
   Elmadhun NY, 2013, J THORAC CARDIOV SUR, V145, P258, DOI 10.1016/j.jtcvs.2012.09.028
   Elmadhun NY, 2012, J THORAC CARDIOV SUR, V144, P1486, DOI 10.1016/j.jtcvs.2012.08.065
   Faber JE, 2014, ARTERIOSCL THROM VAS, V34, P1854, DOI 10.1161/ATVBAHA.114.303929
   Faber JE, 2011, ARTERIOSCL THROM VAS, V31, P1748, DOI 10.1161/ATVBAHA.111.227314
   FALK E, 1985, CIRCULATION, V71, P699, DOI 10.1161/01.CIR.71.4.699
   Fearon WF, 2003, CIRCULATION, V108, P2198, DOI 10.1161/01.CIR.0000099521.31396.9D
   Fearon WF, 2017, CIRC-CARDIOVASC INTE, V10, DOI 10.1161/CIRCINTERVENTIONS.117.005361
   Fearon WF, 2013, CIRCULATION, V127, P2436, DOI 10.1161/CIRCULATIONAHA.112.000298
   Ferguson R J, 1974, Am J Cardiol, V34, P764, DOI 10.1016/0002-9149(74)90693-6
   Fogarty JA, 2004, CIRCULATION, V109, P664, DOI 10.1161/01.CIR.0000112580.31594.F9
   Fogarty JA, 2009, J VASC RES, V46, P152, DOI 10.1159/000152351
   Ford TJ, 2020, JACC-CARDIOVASC INTE, V13, P1847, DOI 10.1016/j.jcin.2020.05.052
   FULTON W. F. M., 1963, SCOT MED JOUR, V8, P466
   Gould KL, 2018, J AM COLL CARDIOL, V72, P2643, DOI 10.1016/j.jacc.2018.07.106
   Gould KL, 2016, CIRCULATION, V133, P1431, DOI 10.1161/CIRCULATIONAHA.116.022037
   Griffin KL, 2001, CIRCULATION, V104, P1393, DOI 10.1161/hc3601.094274
   Hambrecht R, 2000, NEW ENGL J MED, V342, P454, DOI 10.1056/NEJM200002173420702
   Hanna MA, 2014, J APPL PHYSIOL, V117, P616, DOI 10.1152/japplphysiol.01296.2013
   Hattan N, 2007, BASIC RES CARDIOL, V102, P217, DOI 10.1007/s00395-007-0646-3
   Heaps CL, 2006, AM J PHYSIOL-HEART C, V290, pH1128, DOI 10.1152/ajpheart.00973.2005
   Heaps CL, 2004, J APPL PHYSIOL, V97, P310, DOI 10.1152/japplphysiol.01400.2003
   Heaps CL, 2020, AM J PHYSIOL-HEART C, V319, pH915, DOI 10.1152/ajpheart.00384.2020
   Heaps CL, 2014, MICROCIRCULATION, V21, P388, DOI 10.1111/micc.12116
   Heaps CL, 2011, J APPL PHYSIOL, V111, P587, DOI 10.1152/japplphysiol.00338.2011
   HEATON WH, 1978, CIRCULATION, V57, P575, DOI 10.1161/01.CIR.57.3.575
   Henry TD, 2003, CIRCULATION, V107, P1359, DOI 10.1161/01.CIR.0000061911.47710.8A
   Heusch G, 2019, BASIC RES CARDIOL, V114, DOI 10.1007/s00395-019-0756-8
   Heusch G, 2018, INT J CARDIOL, V258, P17, DOI 10.1016/j.ijcard.2018.02.010
   Hinkel R, 2017, J AM COLL CARDIOL, V69, P131, DOI 10.1016/j.jacc.2016.10.058
   Hong HS, 2002, ARTERIOSCL THROM VAS, V22, P2059, DOI 10.1161/01.ATV.0000041844.54849.7E
   Jamaiyar A, 2019, AM J PHYSIOL-HEART C, V316, pH1, DOI 10.1152/ajpheart.00145.2018
   Jo YS, 2020, J AM HEART ASSOC, V9, DOI 10.1161/JAHA.119.015507
   Kang LS, 2011, AM J PHYSIOL-HEART C, V300, pH2105, DOI 10.1152/ajpheart.00349.2010
   Kang LS, 2009, AM J PHYSIOL-HEART C, V297, pH1087, DOI 10.1152/ajpheart.00356.2009
   Karamasis GV, 2018, CIRC-CARDIOVASC INTE, V11, DOI 10.1161/CIRCINTERVENTIONS.118.006941
   Kaski JC, 2018, CIRCULATION, V138, P1463, DOI 10.1161/CIRCULATIONAHA.118.031373
   Katz PS, 2011, BASIC RES CARDIOL, V106, P1123, DOI 10.1007/s00395-011-0201-0
   Keulards DCJ, 2021, NETH HEART J, V29, P22, DOI 10.1007/s12471-020-01470-6
   Keulards DCJ, 2020, J AM HEART ASSOC, V9, DOI 10.1161/JAHA.119.015669
   Kleinbongard P, 2012, J MOL CELL CARDIOL, V52, P890, DOI 10.1016/j.yjmcc.2011.06.022
   Kleinbongard P, 2011, CIRC RES, V108, P344, DOI 10.1161/CIRCRESAHA.110.235713
   Korshunov VA, 2007, ARTERIOSCL THROM VAS, V27, P1722, DOI 10.1161/ATVBAHA.106.129254
   Korzick DH, 2005, CARDIOVASC RES, V66, P384, DOI 10.1016/j.cardiores.2005.01.015
   Kulik A, 2015, CIRCULATION, V131, P927, DOI 10.1161/CIR.0000000000000182
   KUO L, 1992, CIRC RES, V70, P465, DOI 10.1161/01.RES.70.3.465
   Laham RJ, 2000, J PHARMACOL EXP THER, V292, P795
   LAMBERT PR, 1977, J CLIN INVEST, V59, P1, DOI 10.1172/JCI108606
   Lassaletta AD, 2012, BASIC RES CARDIOL, V107, DOI 10.1007/s00395-012-0243-y
   Leblanc AJ, 2013, MICROCIRCULATION, V20, P365, DOI 10.1111/micc.12028
   LeBlanc AJ, 2009, AM J PHYSIOL-REG I, V297, pR1713, DOI 10.1152/ajpregu.00178.2009
   LeBlanc AJ, 2008, AM J PHYSIOL-HEART C, V295, pH2280, DOI 10.1152/ajpheart.00541.2008
   Lee KT, 2012, PACE, V35, P544, DOI 10.1111/j.1540-8159.2012.03355.x
   LONGHURST JC, 1985, J APPL PHYSIOL, V59, P392, DOI 10.1152/jappl.1985.59.2.392
   Lopez JJ, 1998, CARDIOVASC RES, V40, P272, DOI 10.1016/S0008-6363(98)00136-9
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Marzilli M, 2000, J AM COLL CARDIOL, V35, P327, DOI 10.1016/S0735-1097(99)00554-9
   McCallinhart PE, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01463
   Merkus D, 2003, CARDIOVASC RES, V59, P745, DOI 10.1016/S0008-6363(03)00479-6
   Merkus D, 2002, AM J PHYSIOL-HEART C, V283, pH1915, DOI 10.1152/ajpheart.00223.2002
   Merkus D, 2001, AM J PHYSIOL-HEART C, V280, pH1674, DOI 10.1152/ajpheart.2001.280.4.H1674
   Merkus D, 2006, AM J PHYSIOL-HEART C, V291, pH2075, DOI 10.1152/ajpheart.01109.2005
   Miura H, 2003, CIRC RES, V92, P151, DOI 10.1161/01.RES.0000052671.53256.49
   Möbius-Winkler S, 2016, CIRCULATION, V133, P1438, DOI 10.1161/CIRCULATIONAHA.115.016442
   Momose M, 2002, EUR J NUCL MED MOL I, V29, P1675, DOI 10.1007/s00259-002-0977-0
   Morbidelli L, 2010, AM J PHYSIOL-REG I, V298, pR824, DOI 10.1152/ajpregu.00222.2009
   Muller-Delp JM, 2018, J APPL PHYSIOL, V124, P140, DOI 10.1152/japplphysiol.00459.2017
   Murthy VL, 2012, CIRCULATION, V126, P1858, DOI 10.1161/CIRCULATIONAHA.112.120402
   Nagy JA, 2008, ANGIOGENESIS, V11, P109, DOI 10.1007/s10456-008-9099-z
   NEILL WA, 1979, CIRCULATION, V60, P1513, DOI 10.1161/01.CIR.60.7.1513
   Niccoli G, 2013, EUR HEART J, V34, P729, DOI 10.1093/eurheartj/ehs393
   Niccoli G, 2010, EUR HEART J, V31, P2449, DOI 10.1093/eurheartj/ehq299
   Niccoli G, 2009, J AM COLL CARDIOL, V54, P281, DOI 10.1016/j.jacc.2009.03.054
   NIEBAUER J, 1995, AM J CARDIOL, V76, P771, DOI 10.1016/S0002-9149(99)80224-0
   Niebauer J, 1997, CIRCULATION, V96, P2534, DOI 10.1161/01.CIR.96.8.2534
   NITENBERG A, 1993, DIABETES, V42, P1017, DOI 10.2337/diabetes.42.7.1017
   NOLEWAJKA AJ, 1979, CIRCULATION, V60, P114, DOI 10.1161/01.CIR.60.1.114
   O'Konski M S, 1987, Am J Cardiovasc Pathol, V1, P69
   Park JJ, 2019, J KOREAN MED SCI, V34, DOI 10.3346/jkms.2019.34.e202
   Park KW, 1996, ANESTHESIOLOGY, V85, P584, DOI 10.1097/00000542-199609000-00018
   Pohl T, 2001, J AM COLL CARDIOL, V38, P1872, DOI 10.1016/S0735-1097(01)01675-8
   Potz BA, 2018, J THORAC CARDIOV SUR, V155, P2492, DOI 10.1016/j.jtcvs.2017.12.127
   Potz BA, 2017, J THORAC CARDIOV SUR, V153, P342, DOI 10.1016/j.jtcvs.2016.09.087
   Potz BA, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.116.003694
   Pung YF, 2012, ARTERIOSCL THROM VAS, V32, P325, DOI 10.1161/ATVBAHA.111.241802
   Rapps JA, 1997, CIRCULATION, V95, P231, DOI 10.1161/01.CIR.95.1.231
   Rapps JA, 1998, CIRCULATION, V98, P1675, DOI 10.1161/01.CIR.98.16.1675
   Robich MP, 2010, CIRCULATION, V122, pS142, DOI 10.1161/CIRCULATIONAHA.109.920132
   Robles JC, 2011, AM J PHYSIOL-HEART C, V300, pH1201, DOI 10.1152/ajpheart.00957.2010
   ROTH DM, 1990, CIRCULATION, V82, P1778, DOI 10.1161/01.CIR.82.5.1778
   ROTH DM, 1987, AM J PHYSIOL, V253, pH1279, DOI 10.1152/ajpheart.1987.253.5.H1279
   Sabe AA, 2016, J THORAC CARDIOV SUR, V151, P245, DOI 10.1016/j.jtcvs.2015.08.101
   Sabe AA, 2015, J MED FOOD, V18, P60, DOI 10.1089/jmf.2014.0036
   SABER RS, 1993, J AM COLL CARDIOL, V22, P1283, DOI 10.1016/0735-1097(93)90531-5
   Saeed M, 2013, RADIOLOGY, V268, P98, DOI 10.1148/radiol.13122286
   Sambuceti G, 1997, CIRCULATION, V95, P2652, DOI 10.1161/01.CIR.95.12.2652
   SANDERS M, 1978, AM J PHYSIOL, V234, pH614, DOI 10.1152/ajpheart.1978.234.5.H614
   Sandner P, 2021, HANDB EXP PHARMACOL, V264, P355, DOI 10.1007/164_2018_197
   Sato K, 2001, J AM COLL CARDIOL, V37, P616, DOI 10.1016/S0735-1097(00)01144-X
   Sato K, 2000, ANN THORAC SURG, V70, P2113, DOI 10.1016/S0003-4975(00)02018-X
   Schaper W, 1971, COLLATERAL CIRCULATI, P5
   SCHEEL KW, 1981, CIRC RES, V48, P523, DOI 10.1161/01.RES.48.4.523
   SCHULER G, 1992, J AM COLL CARDIOL, V19, P34, DOI 10.1016/0735-1097(92)90048-R
   Sellke FW, 1996, AM J PHYSIOL-HEART C, V271, pH713, DOI 10.1152/ajpheart.1996.271.2.H713
   Sellke FW, 1996, SURGERY, V120, P182, DOI 10.1016/S0039-6060(96)80286-8
   SELLKE FW, 1990, CIRCULATION, V81, P1938, DOI 10.1161/01.CIR.81.6.1938
   SELLKE FW, 1992, AM J PHYSIOL, V262, pH1669, DOI 10.1152/ajpheart.1992.262.6.H1669
   SELLKE FW, 1995, J SURG RES, V59, P185, DOI 10.1006/jsre.1995.1152
   Sellke N, 2018, J THORAC CARDIOV SUR, V156, P2098, DOI 10.1016/j.jtcvs.2018.05.090
   Setty S, 2003, BASIC RES CARDIOL, V98, P416, DOI 10.1007/s00395-003-0418-7
   Sezer M, 2018, J AM HEART ASSOC, V7, DOI 10.1161/JAHA.118.009949
   Sezer M, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.116.003995
   Shipley RD, 2005, CARDIOVASC RES, V66, P374, DOI 10.1016/j.cardiores.2004.11.005
   Simons M, 2002, CIRCULATION, V105, P788, DOI 10.1161/hc0802.104407
   Sodha NR, 2008, J CARDIAC SURG, V23, P312, DOI 10.1111/j.1540-8191.2008.00600.x
   Sodha NR, 2008, MICROVASC RES, V75, P238, DOI 10.1016/j.mvr.2007.06.008
   Sodha NR, 2009, AM J PHYSIOL-HEART C, V296, pH428, DOI 10.1152/ajpheart.00283.2008
   Sorop O, 2008, CIRC RES, V102, P795, DOI 10.1161/CIRCRESAHA.108.172528
   Sorop O, 2020, CARDIOVASC RES, V116, P756, DOI 10.1093/cvr/cvaa002
   Sorop O, 2016, AM J PHYSIOL-HEART C, V311, pH1339, DOI 10.1152/ajpheart.00458.2015
   Stone PH, 2012, CIRCULATION, V126, P172, DOI 10.1161/CIRCULATIONAHA.112.096438
   Taqueti VR, 2018, J AM COLL CARDIOL, V72, P2625, DOI 10.1016/j.jacc.2018.09.042
   Thielmann M, 2002, CIRC RES, V90, P807, DOI 10.1161/01.RES.0000014451.75415.36
   TOMANEK RJ, 1992, CIRCULATION, V86, P320, DOI 10.1161/01.CIR.86.1.320
   TOMANEK RJ, 1991, CIRC RES, V69, P1068, DOI 10.1161/01.RES.69.4.1068
   Trask AJ, 2012, VASC PHARMACOL, V57, P187, DOI 10.1016/j.vph.2012.07.007
   Udelson JE, 2000, CIRCULATION, V102, P1605, DOI 10.1161/01.CIR.102.14.1605
   UREN NG, 1993, J AM COLL CARDIOL, V21, P612, DOI 10.1016/0735-1097(93)90092-F
   Usui E, 2018, JACC-CARDIOVASC INTE, V11, P2058, DOI 10.1016/j.jcin.2018.07.012
   van de Hoef TP, 2020, JACC-CARDIOVASC INTE, V13, P20, DOI 10.1016/j.jcin.2019.08.052
   van den Heuvel M, 2012, AM J PHYSIOL-HEART C, V302, pH85, DOI 10.1152/ajpheart.00311.2011
   Vásquez-Vivar J, 1998, P NATL ACAD SCI USA, V95, P9220, DOI 10.1073/pnas.95.16.9220
   Völzke H, 2007, INT J CARDIOL, V116, P46, DOI 10.1016/j.ijcard.2006.02.008
   Voisine P, 2004, SURGERY, V136, P407, DOI 10.1016/j.surg.2004.05.017
   von Scholten BJ, 2016, DIABETOLOGIA, V59, P371, DOI 10.1007/s00125-015-3799-x
   Weil BR, 2020, AM J PHYSIOL-HEART C, V318, pH696, DOI 10.1152/ajpheart.00502.2019
   White F C, 1992, Am J Cardiovasc Pathol, V4, P193
   WHITE FC, 1992, CIRC RES, V71, P1490, DOI 10.1161/01.RES.71.6.1490
   WHITE FC, 1986, LAB ANIM SCI, V36, P351
   Winzer EB, 2018, J AM HEART ASSOC, V7, DOI 10.1161/JAHA.117.007725
   Wray DW, 2007, AM J PHYSIOL-HEART C, V293, pH2550, DOI 10.1152/ajpheart.00867.2007
   Xie W, 2013, MICROCIRCULATION, V20, P170, DOI 10.1111/micc.12016
   Xie W, 2012, J APPL PHYSIOL, V112, P1546, DOI 10.1152/japplphysiol.01248.2011
   Yun J, 2009, ANTIOXID REDOX SIGN, V11, P1961, DOI [10.1089/ars.2009.2476, 10.1089/ARS.2009.2476]
   Zbinden R, 2004, HEART, V90, P1350, DOI 10.1136/hrt.2003.023267
   Zbinden R, 2007, EUR J CARDIOV PREV R, V14, P250, DOI 10.1097/HJR.0b013e3280565dee
   ZEIHER AM, 1991, CIRCULATION, V84, P1984, DOI 10.1161/01.CIR.84.5.1984
NR 182
TC 13
Z9 14
U1 0
U2 8
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD JUN
PY 2021
VL 320
IS 6
BP H2351
EP H2370
DI 10.1152/ajpheart.00992.2020
PG 20
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA SS2LB
UT WOS:000661571800016
PM 33961506
OA Green Published
DA 2025-06-11
ER

PT J
AU Mohanty, CS
   Kodange, C
   Bhutani, S
   Sarkar, S
   Rajput, GR
   Chaudhary, DK
AF Mohanty, C. S.
   Kodange, Chaitanya
   Bhutani, Sourabh
   Sarkar, Satyasom
   Rajput, G. R.
   Chaudhary, Durgesh Kumar
TI Comparison of Prevalence of Metabolic Syndrome in Submariners with
   Shore-based Naval Personnel
SO JOURNAL OF MARINE MEDICAL SOCIETY
LA English
DT Article
DE Metabolic syndrome; prevalence; shore-based personnel; submariners
ID PHYSICAL-ACTIVITY; MILITARY PERSONNEL; RISK-FACTORS; OBESITY
AB Introduction: Metabolic syndrome refers to a clustering of metabolic risk factors including central obesity, glucose intolerance, low high-density lipoprotein (HDL) cholesterol, high triglycerides, and hypertension. In the naval setting, some occupational characteristics of submariners such as long work hours, lack of physical activity, disturbed circadian rhythm, and stress have a negative influence on the health status of individuals. It is worth speculating that the occupational factors might also influence the development of clinical conditions related to a greater cardiovascular risk such as metabolic syndrome. Materials and Methods: A cross-sectional study was conducted over a period of 2 years. Submariners posted onboard an operational submarine for the past 1 year in the age group 18-45 years and willing to participate in the study were included in the study. Shore-based personnel in the similar age group posted in shore billet for at least 1 year were taken as control. Universal sampling technique was used for selection of subjects. A total of 250 submariners and 250 age-matched shore-based naval personnel were enrolled in the study. The study group was assessed for prevalence and risk factors of metabolic syndrome using national cholesterol education program adult treatment panel III criteria. Results: The mean age of submariners and shore-based personnel was 29.7 +/- 4.9 years and 29.3 +/- 5.3 years, respectively (P = 0.77). 20.8% of the submariners had a body mass index (BMI) more than 25 kg/m(2) compared to 16.8% in the shore-based group. BMI was higher for the submariners compared to shore-based personnel but the difference was not statistically significant (P = 0.097). The prevalence of systolic and diastolic hypertension in submariners was 16.8%-15.2% compared to 11.6% and 10.4% in shore-based group (P > 0.05). Fasting blood sugar levels >100 mg/dl was observed in 14% submariners compared to 8.4% shore-based personnel (P > 0.05). Triglyceride levels of >150 mg/dl was observed in 22.4% submariners compared to 16% shore-based personnel (P = 0.085). HDL level of <40 mg/dl was observed in 13.6% submariners compared to 8.8% in shore-based personnel (P = 0.12). The prevalence of risk factors such as alcohol consumption (34% vs. 26%) and smoking (3.6% vs. 1.1%) and low physical activity (30% vs. 21.2%) were higher in the submariners as compared to the shore-based personnel though the difference was not statistically significant. The prevalence of metabolic syndrome was 9.2% in submariners compared to 6.4% in shore-based personnel. The difference was not statistically significant (P = 0.31). The overall prevalence of metabolic syndrome among submariners was higher than shore-based personnel but it was less compared to studies conducted on the Indian general population in urban areas. Conclusion: There is a need for preventive and/ or therapeutic programs focused on cardiovascular and metabolic health for submariners.
C1 [Mohanty, C. S.; Bhutani, Sourabh] INHS Asvini, Inst Naval Med, Dept Marine Med, Mumbai, Maharashtra, India.
   [Kodange, Chaitanya] King Hamad Univ Hosp, Dept Div & Hyperbar Med, Al Sayh, Bahrain.
   [Sarkar, Satyasom; Rajput, G. R.] INHS Asvini, Dept Dermatol, Mumbai, Maharashtra, India.
   [Chaudhary, Durgesh Kumar] Army Hosp Res & Referral, Dept Internal Med, New Delhi, India.
RP Chaudhary, DK (corresponding author), Army Hosp Res & Referral, Dept Internal Med, New Delhi, India.
EM drdurgesh07@gmail.com
RI Bhutani, Sourabh/AAY-9893-2020
CR Al-Qahtani DA, 2005, SAUDI MED J, V26, P1360
   Bauduceau B, 2005, DIABETES METAB, V31, P353, DOI 10.1016/S1262-3636(07)70204-5
   Bhalwar Rajvir, 2020, Med J Armed Forces India, V76, P8, DOI 10.1016/j.mjafi.2019.12.001
   Bhalwar Rajvir, 2006, Med J Armed Forces India, V62, P146, DOI 10.1016/S0377-1237(06)80059-6
   Broekhuizen LN, 2011, EUR J CARDIOV PREV R, V18, P209, DOI 10.1177/1741826710389397
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   da Costa FF, 2011, ARQ BRAS CARDIOL, V97, P485, DOI 10.1590/S0066-782X2011005000113
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Ekelund U, 2005, DIABETES CARE, V28, P1195, DOI 10.2337/diacare.28.5.1195
   Gupta A, 2003, DIABETES RES CLIN PR, V61, P69, DOI 10.1016/S0168-8227(03)00085-8
   Hartwell J, 2009, A comparison of the prevalence of metabolic syndrome among fast-attack submariners with U.S. Civilian males, P1
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Kabir MA, 2012, JAFMC Bangladesh, V8, P47
   Kamran SM, 2015, Pak Armed Forces Med J, V65, P777
   Kanjilal S, 2008, VASC HEALTH RISK MAN, V4, P189, DOI 10.2147/vhrm.2008.04.01.189
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Lin XL, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-71908-9
   Manaf MRA, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-87248-1
   Mathieu P, 2009, HYPERTENSION, V53, P577, DOI 10.1161/HYPERTENSIONAHA.108.110320
   Nillakupt Kamolthip, 2010, J Med Assoc Thai, V93 Suppl 6, pS179
   Paulhus M, 2014, US PHARM, V39, P43
   Teo KK, 2017, CAN J CARDIOL, V33, P358, DOI 10.1016/j.cjca.2016.12.014
   Wang MZ, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18094667
   Wijndaele K, 2009, EUR J CLIN NUTR, V63, P421, DOI 10.1038/sj.ejcn.1602944
NR 24
TC 0
Z9 0
U1 0
U2 2
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 0975-3605
EI 2589-1235
J9 J MAR MED SOC
JI J. Mar. Med. Soc.
PD JUL-DEC
PY 2023
VL 25
IS 2
BP 175
EP 181
DI 10.4103/jmms.jmms_47_23
PG 7
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA Y8FB6
UT WOS:001107551800015
OA gold
DA 2025-06-11
ER

PT J
AU Sánchez-Villegas, A
   Ruíz-Canela, M
   de la Fuente-Arrillaga, C
   Gea, A
   Shivappa, N
   Hébert, JR
   Martínez-González, MA
AF Sanchez-Villegas, Almudena
   Ruiz-Canela, Miguel
   de la Fuente-Arrillaga, Carmen
   Gea, Alfredo
   Shivappa, Nitin
   Hebert, James R.
   Martinez-Gonzalez, Miguel A.
TI Dietary inflammatory index, cardiometabolic conditions and depression in
   the Seguimiento Universidad de Navarra cohort study
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Cohort studies; Dietary patterns; Depression; Anti-inflammation;
   Diabetes
ID C-REACTIVE PROTEIN; SELF-REPORTED DIAGNOSIS; METABOLIC SYNDROME;
   ASSOCIATION; SYMPTOMS; PATTERN; INTERLEUKIN-6; RISK; METAANALYSIS;
   VALIDATION
AB Only one prospective study has analysed the relationship between the inflammatory properties of diet and risk of depression thus far. The aim of this study was to assess the association between the dietary inflammatory index (DII) and the incidence of depression. In a cohort study of 15 093 university graduates, participants completed a validated FFQ at baseline and after 10 years of follow-up. The DII was calculated based on the FFQ. Each of the twenty-eight nutrients or foods received a score based on findings from the peer-reviewed literature reporting on the relationships between diet and inflammatory biomarkers (IL-1 beta, IL-4, IL-6, IL-10, TNF-alpha and C-reactive protein). Participants were classified as having depression if they reported a new clinical diagnosis of depression by a physician, antidepressant drugs, or both. Multivariable Cox regression models were used to estimate hazard ratios (HR) of depression according to quintiles of the DII. After a median 8.5 years of follow-up, we observed 1051 incident cases of depression. The HR for participants in the highest quintile of DII (strongly pro-inflammatory) was 1.47 (95 % CI 1.17, 1.85) compared with those in the bottom quintile, with a significant dose-response relationship (P-trend=0.01). In the subgroup analyses, the association between DII and depression was stronger among participants > 55 years and among those with cardiometabolic comorbidities (HR 2.70; 95 % CI 1.22, 5.97 and HR 1.80; 95 % CI 1.27, 2.57, respectively). A pro-inflammatory diet was associated with a significantly higher risk of depression in a Mediterranean population. This association was stronger among older subjects and subjects with cardiometabolic diseases.
C1 [Sanchez-Villegas, Almudena] Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci, Nutr Res Grp, Las Palmas Gran Canaria 35016, Spain.
   [Sanchez-Villegas, Almudena; Ruiz-Canela, Miguel; de la Fuente-Arrillaga, Carmen; Gea, Alfredo; Martinez-Gonzalez, Miguel A.] Inst Salud Carlos III, Ciber Fisiopatol Obesidad & Nutr CIBER OBN, Madrid 28029, Spain.
   [Ruiz-Canela, Miguel; de la Fuente-Arrillaga, Carmen; Gea, Alfredo; Martinez-Gonzalez, Miguel A.] Univ Navarra, Dept Prevent Med & Publ Hlth, Pamplona 31008, Spain.
   [Shivappa, Nitin; Hebert, James R.] Univ S Carolina, Canc Prevent & Control Program, Columbia, SC 29208 USA.
   [Shivappa, Nitin; Hebert, James R.] Univ S Carolina, Dept Epidemiol & Biostat, Arnold Sch Publ Hlth, Columbia, SC 29208 USA.
C3 Universidad de Las Palmas de Gran Canaria; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III;
   University of Navarra; University of South Carolina System; University
   of South Carolina Columbia; University of South Carolina System;
   University of South Carolina Columbia
RP Sánchez-Villegas, A (corresponding author), Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci, Nutr Res Grp, Las Palmas Gran Canaria 35016, Spain.
EM almudena.sanchez@ulpgc.es
RI Abad-Gurumeta, Alfredo/M-2337-2019; Martinez-Gonzalez,
   Miguel/AAE-7669-2019; Hebert, James/IUO-5628-2023; Ruiz-Canela,
   Miguel/JYP-1794-2024; Sanchez-Villegas, Almudena/T-6733-2019; Shivappa,
   Nitin/X-2215-2018; Ruiz-Canela, Miguel/I-7738-2016
OI Sanchez Villegas, Almudena/0000-0001-7733-9238; Ruiz-Canela,
   Miguel/0000-0002-7684-2787; Gea, Alfredo/0000-0002-2229-4690
FU Spanish Government [PI10/02658, PI10/02293, PI13/00615, PI14/01798,
   RD06/0045, G03/140, 87/2010]; Navarra Regional Government [45/2011,
   27/2011]; University of Navarra; United States National Institute of
   Diabetes and Digestive and Kidney Diseases [R44DK103377]
FX The SUN Study has received funding from the Spanish Government (current
   grants PI10/02658, PI10/02293, PI13/00615, PI14/01798, RD06/0045,
   G03/140 and 87/2010), the Navarra Regional Government (45/2011, 27/2011)
   and the University of Navarra. A. G. is supported by a FPU fellowship
   from the Spanish Government. N. S. and J. R. H. were supported by grant
   number R44DK103377 from the United States National Institute of Diabetes
   and Digestive and Kidney Diseases.
CR Akbaraly TN, 2009, BRIT J PSYCHIAT, V195, P408, DOI 10.1192/bjp.bp.108.058925
   ALONSO A, 2005, BMC PUBLIC HEALTH, V5, P94, DOI DOI 10.1186/1471-2458-5-94
   Au B, 2014, J PSYCHOSOM RES, V77, P180, DOI 10.1016/j.jpsychores.2014.07.012
   Bes-Rastrollo M, 2005, Rev. Esp. Obes, V3, P352
   Bjorntorp P, 1993, Obes Res, V1, P206
   Casas R, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100084
   Chocano-Bedoya PO, 2014, J AFFECT DISORDERS, V163, P25, DOI 10.1016/j.jad.2014.03.023
   Chrysohoou C, 2004, J AM COLL CARDIOL, V44, P152, DOI 10.1016/j.jacc.2004.03.039
   de la Fuente-Arrillaga C, 2010, PUBLIC HEALTH NUTR, V13, P1364, DOI 10.1017/S1368980009993065
   Dipnall JF, 2015, J AFFECT DISORDERS, V174, P215, DOI 10.1016/j.jad.2014.11.030
   Doyle TA, 2013, J PSYCHOSOM RES, V75, P419, DOI 10.1016/j.jpsychores.2013.08.006
   Fernández-Ballarth JD, 2010, BRIT J NUTR, V103, P1808, DOI 10.1017/S0007114509993837
   Fernández-Montero A, 2011, GAC SANIT, V25, P303, DOI 10.1016/j.gaceta.2011.02.009
   Flehmig G, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0099785
   Fung TT, 2001, AM J CLIN NUTR, V73, P61
   Greenland S., 2008, Modern Epidemiology, V3rd, P359
   Grosse L, 2015, BRAIN BEHAV IMMUN, V44, P48, DOI 10.1016/j.bbi.2014.08.004
   Hood KK, 2012, DIABETES CARE, V35, P2443, DOI 10.2337/dc11-2329
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Jacka FN, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024805
   Khandaker GM, 2014, JAMA PSYCHIAT, V71, P1121, DOI 10.1001/jamapsychiatry.2014.1332
   Laake JPS, 2014, DIABETES CARE, V37, P2186, DOI 10.2337/dc13-2522
   Lai JS, 2014, AM J CLIN NUTR, V99, P181, DOI 10.3945/ajcn.113.069880
   Le Port A, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051593
   Lopez-Garcia E, 2004, AM J CLIN NUTR, V80, P1029, DOI 10.1093/ajcn/80.4.1029
   Lucas M, 2014, BRAIN BEHAV IMMUN, V36, P46, DOI 10.1016/j.bbi.2013.09.014
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Martínez-González MA, 2005, PUBLIC HEALTH NUTR, V8, P920, DOI 10.1079/PHN2005745
   McInnis CM, 2014, BRAIN BEHAV IMMUN, V42, P33, DOI 10.1016/j.bbi.2014.07.018
   Ouchi N, 2011, NAT REV IMMUNOL, V11, P85, DOI 10.1038/nri2921
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pasco JA, 2010, BRIT J PSYCHIAT, V197, P372, DOI 10.1192/bjp.bp.109.076430
   Poole L, 2011, J PSYCHOSOM RES, V71, P61, DOI 10.1016/j.jpsychores.2010.12.009
   Rienks J, 2013, EUR J CLIN NUTR, V67, P75, DOI 10.1038/ejcn.2012.193
   Rothman KJ., 2008, Modern epidemiology, VThird, P168
   Sanchez-Villegas A, 2013, BMC MED, V11, DOI [10.1186/1741-7015-11-3, 10.1186/1741-7015-11-208]
   Sanchez-Villegas A, 2008, BMC PSYCHIATRY, V8, DOI 10.1186/1471-244X-8-43
   Sánchez-Villegas A, 2009, ARCH GEN PSYCHIAT, V66, P1090, DOI 10.1001/archgenpsychiatry.2009.129
   Schmidt FM, 2014, J PSYCHIATR RES, V55, P29, DOI 10.1016/j.jpsychires.2014.04.021
   Seguí-Gómez M, 2006, INT J EPIDEMIOL, V35, P1417, DOI 10.1093/ije/dyl223
   Shivappa N, 2015, BR J NUTR IN PRESS
   Shivappa N, 2014, CANCER EPIDEM BIOMAR, V23, P2383, DOI 10.1158/1055-9965.EPI-14-0537
   Shivappa N, 2014, PUBLIC HEALTH NUTR, V17, P1825, DOI 10.1017/S1368980013002565
   Shivappa N, 2014, PUBLIC HEALTH NUTR, V17, P1689, DOI 10.1017/S1368980013002115
   Valkanova V, 2013, BIOL PSYCHIAT, V73, P406, DOI 10.1016/j.biopsych.2012.10.028
   Willett W. C., 1998, Nutritional Epidemiology, V2nd ed., P321, DOI DOI 10.1093/AJCN/69.5.1020
   Wirth MD, 2014, J OCCUP ENVIRON MED, V56, P986, DOI 10.1097/JOM.0000000000000213
   Wirth MD, 2014, J OCCUP ENVIRON MED, V56, P145, DOI 10.1097/JOM.0000000000000088
   Wood L, 2014, RESPIROLOGY, V19, P37, DOI 10.1111/cea.12323
   Zunszain Patricia A, 2013, Curr Top Behav Neurosci, V14, P135, DOI 10.1007/7854_2012_211
   ,, 2008, The global burden of disease: 2004 update
NR 51
TC 93
Z9 97
U1 2
U2 25
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD NOV 14
PY 2015
VL 114
IS 9
BP 1471
EP 1479
DI 10.1017/S0007114515003074
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CV8IL
UT WOS:000364526600016
PM 26344165
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Nemeckova, I
   Eissazadeh, S
   Rathouska, JU
   Silhavy, J
   Malinska, H
   Pravenec, M
   Nachtigal, P
AF Nemeckova, Ivana
   Eissazadeh, Samira
   Rathouska, Jana Urbankova
   Silhavy, Jan
   Malinska, Hana
   Pravenec, Michal
   Nachtigal, Petr
TI Transgenic human C-reactive protein affects oxidative stress but not
   inflammation biomarkers in the aorta of spontaneously hypertensive rats
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Article
DE C-reactive protein; Spontaneously hypertensive rat; Aorta; Endothelial
   dysfunction; Oxidative stress
ID ENDOTHELIAL DYSFUNCTION; SOLUBLE ENDOGLIN; ENOS EXPRESSION;
   GENE-TRANSFER; HYPERCHOLESTEROLEMIA; ADIPONECTIN
AB Background C-reactive protein (CRP) is an acute inflammatory protein detected in obese patients with metabolic syndrome. Moreover, increased CRP levels have been linked with atherosclerotic disease, congestive heart failure, and ischemic heart disease, suggesting that it is not only a biomarker but also plays an active role in the pathophysiology of cardiovascular diseases. Since endothelial dysfunction plays an essential role in various cardiovascular pathologies and is characterized by increased expression of cell adhesion molecules and inflammatory markers, we aimed to detect specific markers of endothelial dysfunction, inflammation, and oxidative stress in spontaneously hypertensive rats (SHR) expressing human CRP. This model is genetically predisposed to the development of the metabolic syndrome.Methods Transgenic SHR male rats (SHR-CRP) and non-transgenic SHR (SHR) at the age of 8 months were used. Metabolic profile (including serum and tissue triglyceride (TAG), serum insulin concentrations, insulin-stimulated incorporation of glucose, and serum non-esterified fatty acids (NEFA) levels) was measured. In addition, human serum CRP, MCP-1 (monocyte chemoattractant protein-1), and adiponectin were evaluated by means of ELISA, histological analysis was used to study morphological changes in the aorta, and western blot analysis of aortic tissue was performed to detect expression of endothelial, inflammatory, and oxidative stress markers.Results The presence of human CRP was associated with significantly decreased insulin-stimulated glycogenesis in skeletal muscle, increased muscle and hepatic accumulation of TAG and decreased plasmatic cGMP concentrations, reduced adiponectin levels, and increased monocyte chemoattractant protein-1 (MCP-1) levels in the blood, suggesting pro-inflammatory and presence of multiple features of metabolic syndrome in SHR-CRP animals. Histological analysis of aortic sections did not reveal any visible morphological changes in animals from both SHR and SHR-CRP rats. Western blot analysis of the expression of proteins related to the proper function of endothelium demonstrated significant differences in the expression of p-eNOS/eNOS in the aorta, although endoglin (ENG) protein expression remained unaffected. In addition, the presence of human CRP in SHR in this study did not affect the expression of inflammatory markers, namely p-NFkB, P-selectin, and COX2 in the aorta. On the other hand, biomarkers related to oxidative stress, such as HO-1 and SOD3, were significantly changed, indicating the induction of oxidative stress.Conclusions Our findings demonstrate that CRP alone cannot fully induce the expression of endothelial dysfunction biomarkers, suggesting other risk factors of cardiovascular disorders are necessary to be involved to induce endothelial dysfunction with CRP.
C1 [Nemeckova, Ivana; Eissazadeh, Samira; Rathouska, Jana Urbankova; Nachtigal, Petr] Charles Univ Prague, Dept Biol & Med Sci, Fac Pharm Hradec Kralove, Heyrovskeho 1203, Hradec Kralove 50003, Czech Republic.
   [Silhavy, Jan; Pravenec, Michal] Acad Sci Czech Republ, Inst Physiol, Prague, Czech Republic.
   [Malinska, Hana] Inst Clin & Expt Med, Ctr Expt Med, Prague, Czech Republic.
C3 Charles University Prague; Czech Academy of Sciences; Institute of
   Physiology of the Czech Academy of Sciences; Institute for Clinical &
   Experimental Medicine (IKEM)
RP Nachtigal, P (corresponding author), Charles Univ Prague, Dept Biol & Med Sci, Fac Pharm Hradec Kralove, Heyrovskeho 1203, Hradec Kralove 50003, Czech Republic.
EM petr.nachtigal@faf.cuni.cz
RI Silhavy, Jan/B-5292-2014; Eissazadeh, Samira/ABE-2495-2020; Nachtigal,
   Petr/S-8022-2017; Nemeckova, Ivana/T-6610-2017; Rathouska,
   Jana/Q-2796-2016
OI Rathouska, Jana/0000-0001-6363-9715; Eissazadeh,
   Samira/0000-0002-6021-6589
FU Program EXCELES
FX Not applicable.
CR Abramson JL, 2005, ATHEROSCLEROSIS, V178, P115, DOI 10.1016/j.atherosclerosis.2004.08.007
   Araujo JA, 2012, FRONT PHARMACOL, V3, DOI 10.3389/fphar.2012.00119
   Bisoendial RJ, 2010, EUR HEART J, V31, P2087, DOI 10.1093/eurheartj/ehq238
   Brazao SC, 2023, LIFE SCI, V332, DOI 10.1016/j.lfs.2023.122082
   Davignon J, 2004, CIRCULATION, V109, P27, DOI 10.1161/01.CIR.0000131515.03336.f8
   Durante W, 2011, FRONT BIOSCI-LANDMRK, V16, P2372, DOI 10.2741/3860
   Foresman EL, 2013, REDOX BIOL, V1, P292, DOI 10.1016/j.redox.2013.04.003
   Hosick PA, 2012, AM J PHYSIOL-REG I, V302, pR207, DOI 10.1152/ajpregu.00517.2011
   Iacoviello L, 2001, Ital Heart J Suppl, V2, P1031
   Iida S, 2005, AM J PHYSIOL-HEART C, V289, pH525, DOI 10.1152/ajpheart.00108.2005
   Kadowaki T, 2006, J CLIN INVEST, V116, P1784, DOI 10.1172/JCI29126
   Keaney John F. Jr., 2000, Molecular Aspects of Medicine, V21, P99, DOI 10.1016/S0098-2997(00)00005-4
   Lahera V, 2007, CURR MED CHEM, V14, P243, DOI 10.2174/092986707779313381
   Lund DD, 2004, AM J PHYSIOL-HEART C, V287, pH805, DOI 10.1152/ajpheart.00907.2003
   Nemeckova I, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0119665
   Pravenec M, 2011, HYPERTENSION, V57, P731, DOI 10.1161/HYPERTENSIONAHA.110.164350
   Rathouska J, 2015, ATHEROSCLEROSIS, V243, P383, DOI 10.1016/j.atherosclerosis.2015.10.003
   Ridker PM, 2008, J PERIODONTOL, V79, P1544, DOI 10.1902/jop.2008.080249
   Santibanez JF, 2007, J CELL PHYSIOL, V210, P456, DOI 10.1002/jcp.20878
   Scheid MP, 2014, REV ENDOCR METAB DIS, V15, P157, DOI 10.1007/s11154-013-9265-5
   Sepulveda JL, 2005, CURR OPIN CARDIOL, V20, P407
   Silhavy J, 2023, METABOLITES, V13, DOI 10.3390/metabo13020192
   Tejera-Muñoz A, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms241914443
   Venugopal SK, 2002, CIRCULATION, V106, P1439, DOI 10.1161/01.CIR.0000033116.22237.F9
   Vitverova B, 2018, ATHEROSCLEROSIS, V271, P15, DOI 10.1016/j.atherosclerosis.2018.02.008
   Zacho J, 2008, NEW ENGL J MED, V359, P1897, DOI 10.1056/NEJMoa0707402
NR 26
TC 1
Z9 1
U1 1
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD APR 16
PY 2024
VL 24
IS 1
AR 211
DI 10.1186/s12872-024-03870-7
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA OA4Y1
UT WOS:001204537400004
PM 38627621
OA gold
DA 2025-06-11
ER

PT J
AU Roberts, JA
   Varma, VR
   Huang, CW
   An, Y
   Oommen, A
   Tanaka, T
   Ferrucci, L
   Elango, P
   Takebayashi, T
   Harada, S
   Iida, M
   Thambisetty, M
AF Roberts, Jackson A.
   Varma, Vijay R.
   Huang, Chiung-Wei
   An, Yang
   Oommen, Anup
   Tanaka, Toshiko
   Ferrucci, Luigi
   Elango, Palchamy
   Takebayashi, Toru
   Harada, Sei
   Iida, Miho
   Thambisetty, Madhav
TI Blood Metabolite Signature of Metabolic Syndrome Implicates Alterations
   in Amino Acid Metabolism: Findings from the Baltimore Longitudinal Study
   of Aging (BLSA) and the Tsuruoka Metabolomics Cohort Study (TMCS)
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE metabolic syndrome; metabolomics; amino acids; fasting glucose;
   triglycerides; waist circumference; blood pressure
ID ELECTROPHORESIS-MASS SPECTROMETRY; ALZHEIMERS-DISEASE; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; TCA CYCLE; RISK; GLUTATHIONE; POPULATION;
   MORTALITY; TRENDS
AB Rapid lifestyle and dietary changes have contributed to a rise in the global prevalence of metabolic syndrome (MetS), which presents a potential healthcare crisis, owing to its association with an increased burden of multiple cardiovascular and neurological diseases. Prior work has identified the role that genetic, lifestyle, and environmental factors can play in the prevalence of MetS. Metabolomics is an important tool to study alterations in biochemical pathways intrinsic to the pathophysiology of MetS. We undertook a metabolomic study of MetS in serum samples from two ethnically distinct, well-characterized cohorts-the Baltimore Longitudinal Study of Aging (BLSA) from the U.S. and the Tsuruoka Metabolomics Cohort Study (TMCS) from Japan. We used multivariate logistic regression to identify metabolites that were associated with MetS in both cohorts. Among the top 25 most significant (lowest p-value) metabolite associations with MetS in each cohort, we identified 18 metabolites that were shared between TMCS and BLSA, the majority of which were classified as amino acids. These associations implicate multiple biochemical pathways in MetS, including branched-chain amino acid metabolism, glutathione production, aromatic amino acid metabolism, gluconeogenesis, and the tricarboxylic acid cycle. Our results suggest that fundamental alterations in amino acid metabolism may be central features of MetS.
C1 [Roberts, Jackson A.; Varma, Vijay R.; Thambisetty, Madhav] NIA, Clin & Translat Neurosci Sect, Lab Behav Neurosci, NIH, Baltimore, MD 21224 USA.
   [Huang, Chiung-Wei; An, Yang] NIA, Brain Aging & Behav Sect, Lab Behav Neurosci, NIH, Baltimore, MD 21224 USA.
   [Oommen, Anup] Natl Univ Ireland Galway, Natl Ctr Biomed Engn Sci, Glycosci Grp, Galway H91 TK33, Ireland.
   [Tanaka, Toshiko; Ferrucci, Luigi; Elango, Palchamy] NIA, Translat Gerontol Branch, NIH, Baltimore, MD 21224 USA.
   [Takebayashi, Toru; Harada, Sei; Iida, Miho] Keio Univ, Dept Prevent Med & Publ Hlth, Tokyo 1608282, Japan.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); National Institutes of Health (NIH) - USA; NIH National
   Institute on Aging (NIA); National Institutes of Health (NIH) - USA; NIH
   National Institute on Aging (NIA); Keio University
RP Thambisetty, M (corresponding author), NIA, Clin & Translat Neurosci Sect, Lab Behav Neurosci, NIH, Baltimore, MD 21224 USA.
EM robertsjaa@nih.gov; vijay.varma@nih.gov; chiung-wei.huang@nih.gov;
   anya@grc.nia.nih.gov; anup.mammen@gmail.com; tanakato@mail.nih.gov;
   ferruccilu@grc.nia.nih.gov; elangop@mail.nih.gov;
   ttakebayashi@a3.keio.jp; seiharada@keio.jp; mihoiida1029@gmail.com;
   thambisettym@mail.nih.gov
RI Iida, Miho/NBX-2743-2025; Tanaka, Toshiko/HKW-0340-2023; Takebayashi,
   Toru/AAB-9356-2019; Harada, Sei/ABA-5975-2020; Ferrucci,
   Luigi/AED-9724-2022
OI Iida, Miho/0000-0001-5527-7574; Tanaka, Toshiko/0000-0002-4161-3829;
   Harada, Sei/0000-0003-2666-4932; Roberts, Jackson/0000-0003-2231-2454;
   Oommen, Anup/0000-0001-7653-5106; Ferrucci, Luigi/0000-0002-6273-1613
FU Intramural Research Program of the NIH, National Institute on Aging;
   Andrew and Lillian A. Posey Foundation
FX This research was supported in part by the Intramural Research Program
   of the NIH, National Institute on Aging. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript. M.T. is grateful for funding support from
   the Andrew and Lillian A. Posey Foundation to the Clinical and
   Translational Neuroscience Section, Laboratory of Behavioral
   Neuroscience, NIA.
CR Baba S, 2001, J Epidemiol, V11, pS87
   Bains JS, 1997, BRAIN RES REV, V25, P335, DOI 10.1016/S0165-0173(97)00045-3
   BENJAMINI Y, 1995, J R STAT SOC B, V57, P289, DOI 10.1111/j.2517-6161.1995.tb02031.x
   Beydoun MA, 2013, J NUTR SCI, V2, DOI 10.1017/jns.2013.19
   Brant LJ, 2010, GENDER MED, V7, P616, DOI 10.1016/j.genm.2010.11.005
   BUCKLEY WT, 1978, BIOCHEM J, V176, P449, DOI 10.1042/bj1760449
   Casanova R, 2016, ALZHEIMERS DEMENT, V12, P815, DOI 10.1016/j.jalz.2015.12.008
   Chen WQ, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.116.005446
   Dekker JM, 2005, CIRCULATION, V112, P666, DOI 10.1161/CIRCULATIONAHA.104.516948
   Elshorbagy AK, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0044166
   Exalto LG, 2015, J NEUROL SCI, V351, P18, DOI 10.1016/j.jns.2015.02.004
   FELIG P, 1973, METABOLISM, V22, P179, DOI 10.1016/0026-0495(73)90269-2
   Fernstrom JD, 2007, J NUTR, V137, p1539S, DOI 10.1093/jn/137.6.1539S
   Ferrucci L, 2008, J GERONTOL A-BIOL, V63, P1416, DOI 10.1093/gerona/63.12.1416
   Flores-Guerrero JL, 2018, J CLIN MED, V7, DOI 10.3390/jcm7120513
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   Fujii H, 2011, DIABETOL INT, V2, P47, DOI 10.1007/s13340-011-0025-z
   Funchal C, 2004, NEUROCHEM RES, V29, P747, DOI 10.1023/B:NERE.0000018846.66943.30
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Gao X, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0095-9
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Harada S, 2016, ENVIRON HEALTH PREV, V21, P283, DOI 10.1007/s12199-016-0519-1
   Hasin Y, 2017, GENOME BIOL, V18, DOI 10.1186/s13059-017-1215-1
   Henglin M, 2019, METABOLITES, V9, DOI 10.3390/metabo9070128
   Hirayama A, 2016, CAPILLARY ELECTROPHORESIS-MASS SPECTROMETRY (CE-MS): PRINCIPLES AND APPLICATIONS, P293
   Hirayama A, 2012, ANAL BIOANAL CHEM, V404, P3101, DOI 10.1007/s00216-012-6412-x
   Hirayama A, 2012, ANALYST, V137, P5026, DOI 10.1039/c2an35492f
   Hu FB, 2011, DIABETES CARE, V34, P1249, DOI 10.2337/dc11-0442
   Hyman DJ, 2000, ARCH INTERN MED, V160, P2281, DOI 10.1001/archinte.160.15.2281
   Iida M, 2016, MENOPAUSE, V23, P749, DOI 10.1097/GME.0000000000000630
   Islami F, 2015, TRANSL LUNG CANCER R, V4, P327, DOI 10.3978/j.issn.2218-6751.2015.08.04
   JACKSON RH, 1983, J BIOL CHEM, V258, P1857
   JANSSON PA, 1994, J CLIN INVEST, V93, P240, DOI 10.1172/JCI116951
   Johnson CH, 2016, NAT REV MOL CELL BIO, V17, P451, DOI 10.1038/nrm.2016.25
   Kuehnbaum NL, 2013, ANAL CHEM, V85, P10664, DOI 10.1021/ac403171u
   Larsson SC, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-12931-1
   Lee CMY, 2008, DIABETES RES CLIN PR, V81, P377, DOI 10.1016/j.diabres.2008.05.011
   Lent-Schochet D, 2019, WORLD J DIABETES, V10, P23, DOI 10.4239/wjd.v10.i1.23
   Li HJ, 2018, BIOSCIENCE REP, V38, DOI 10.1042/BSR20180127
   Libert DM, 2018, PEERJ, V6, DOI 10.7717/peerj.5410
   Liu LL, 2011, J SEP SCI, V34, P1198, DOI 10.1002/jssc.201000799
   Lord RS, 2008, ALTERN MED REV, V13, P205
   Lotta LA, 2016, PLOS MED, V13, DOI 10.1371/journal.pmed.1002179
   Lovell MA, 2007, NUCLEIC ACIDS RES, V35, P7497, DOI 10.1093/nar/gkm821
   Luque-Contreras D, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/497802
   Lustgarten MS, 2014, J GERONTOL A-BIOL, V69, P717, DOI 10.1093/gerona/glt152
   Mahajan U.V., 2020, BLOOD METABOLITE SIG
   Mahajan UV, 2020, PLOS MED, V17, DOI 10.1371/journal.pmed.1003012
   Metter EJ, 2008, DIABETES CARE, V31, P1026, DOI 10.2337/dc07-2102
   Mielke MM, 2015, AGING CELL, V14, P112, DOI 10.1111/acel.12275
   Ministry of Health LaWoJ, SUMM NAT NUTR HLTH S
   Nakamura M, 2016, ANN CLIN BIOCHEM, V53, P632, DOI 10.1177/0004563215624461
   Newgard CB, 2009, CELL METAB, V9, P565, DOI 10.1016/j.cmet.2009.05.001
   Nunomura A, 2006, J NEUROPATH EXP NEUR, V65, P631, DOI 10.1097/01.jnen.0000228136.58062.bf
   Odegaard AO, 2012, CIRCULATION, V126, P182, DOI 10.1161/CIRCULATIONAHA.111.084004
   Ohashi Y, 2008, MOL BIOSYST, V4, P135, DOI 10.1039/b714176a
   Oyarzabal A, 2013, HUM MUTAT, V34, P355, DOI 10.1002/humu.22242
   Pallister T, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-13722-4
   Pasini E, 2018, NUTRIENTS, V10, DOI 10.3390/nu10040391
   Patel MJ, 2013, OMICS, V17, P627, DOI 10.1089/omi.2013.0031
   Pujos-Guillot E, 2017, J PROTEOME RES, V16, P2262, DOI 10.1021/acs.jproteome.7b00116
   Qin LQ, 2011, J NUTR, V141, P249, DOI 10.3945/jn.110.128520
   Raffaitin C, 2009, DIABETES CARE, V32, P169, DOI 10.2337/dc08-0272
   Razay G, 2007, ARCH NEUROL-CHICAGO, V64, P93, DOI 10.1001/archneur.64.1.93
   Resnick SM, 2003, J NEUROSCI, V23, P3295
   Ruiz-Ramírez A, 2014, CLIN SCI, V126, P19, DOI 10.1042/CS20130164
   Sacks FM, 1999, CLIN CARDIOL, V22, P6, DOI 10.1002/clc.4960221503
   Sallese A, 2017, BIOANALYSIS, V9, P1623, DOI 10.4155/bio-2017-0165
   Sappington DR, 2016, BBA-GEN SUBJECTS, V1860, P836, DOI 10.1016/j.bbagen.2016.01.021
   Sasaki K, 2019, ANAL CHEM, V91, P1295, DOI 10.1021/acs.analchem.8b02994
   SASTRE J, 1989, LIFE SCI, V45, P183, DOI 10.1016/0024-3205(89)90293-2
   Satapati S, 2012, J LIPID RES, V53, P1080, DOI 10.1194/jlr.M023382
   Scholze J, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-529
   Scott HA, 2011, NEUROBIOL AGING, V32, DOI 10.1016/j.neurobiolaging.2010.03.008
   Shin D, 2018, INT J CARDIOL, V259, P216, DOI 10.1016/j.ijcard.2018.01.139
   Soga T, 2000, ANAL CHEM, V72, P1236, DOI 10.1021/ac990976y
   Soga T, 2009, ANAL CHEM, V81, P6165, DOI 10.1021/ac900675k
   Solon-Biet SM, 2019, NAT METAB, V1, P532, DOI 10.1038/s42255-019-0059-2
   Sugimoto M, 2010, METABOLOMICS, V6, P78, DOI 10.1007/s11306-009-0178-y
   Sun L, 2017, ONCOTARGET, V8, P88882, DOI 10.18632/oncotarget.21489
   Talbot LA, 2003, PREV MED, V37, P52, DOI 10.1016/S0091-7435(03)00058-6
   Talbot LA, 2000, MED SCI SPORT EXER, V32, P417, DOI 10.1097/00005768-200002000-00024
   Tamanna Nahid, 2014, Int Sch Res Notices, V2014, P235619, DOI 10.1155/2014/235619
   Teramoto T, 2016, ATHEROSCLEROSIS, V251, P248, DOI 10.1016/j.atherosclerosis.2016.07.001
   Tillin T, 2015, DIABETOLOGIA, V58, P968, DOI 10.1007/s00125-015-3517-8
   Toledo JB, 2017, ALZHEIMERS DEMENT, V13, P965, DOI 10.1016/j.jalz.2017.01.020
   Tulipani S, 2011, J PROTEOME RES, V10, P5047, DOI 10.1021/pr200514h
   van Valkengoed IGM, 2017, NUTR DIABETES, V7, DOI 10.1038/s41387-017-0003-z
   Vanhanen M, 2006, NEUROLOGY, V67, P843, DOI 10.1212/01.wnl.0000234037.91185.99
   Varma VR, 2018, PLOS MED, V15, DOI 10.1371/journal.pmed.1002482
   Verbrugge LM, 1996, J GERONTOL B-PSYCHOL, V51, pS30, DOI 10.1093/geronb/51B.1.S30
   WALAJTYSRODE E, 1980, J BIOL CHEM, V255, P413
   Wang FH, 2019, ATHEROSCLEROSIS, V286, P7, DOI 10.1016/j.atherosclerosis.2019.04.225
   Wang J, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.01140
   Wang TJ, 2013, J CLIN INVEST, V123, P4309, DOI 10.1172/JCI64801
   Wiklund PK, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-40
   Wishart DS, 2018, NUCLEIC ACIDS RES, V46, pD608, DOI 10.1093/nar/gkx1089
   Wu GY, 2004, J NUTR, V134, P489, DOI 10.1093/jn/134.10.2783S
   Yang CD, 2014, MOL CELL, V56, P414, DOI 10.1016/j.molcel.2014.09.025
   Zhong FY, 2017, EXP BIOL MED, V242, P773, DOI 10.1177/1535370217694098
   Zhou B, 2019, LANCET, V394, P639, DOI 10.1016/S0140-6736(19)31145-6
   Zhou XH, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201700262
NR 103
TC 25
Z9 25
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB
PY 2020
VL 21
IS 4
AR 1249
DI 10.3390/ijms21041249
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Chemistry
GA KY4FE
UT WOS:000522524400076
PM 32070008
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Marycz, K
   Kornicka, K
   Irwin-Houston, JM
   Weiss, C
AF Marycz, Krzysztof
   Kornicka, Katarzyna
   Irwin-Houston, Jennifer M.
   Weiss, Christine
TI Combination of resveratrol and 5-azacytydine improves osteogenesis of
   metabolic syndrome mesenchymal stem cells
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Article
DE adipose stem cells; ageing; autophagy; metabolic syndrome; mitochondria;
   osteogenic differentiation
ID OXIDATIVE STRESS; ADIPOSE-TISSUE; INSULIN-RESISTANCE; DNA METHYLATION;
   GENE-EXPRESSION; NADPH OXIDASE; DIFFERENTIATION; OBESITY; INFLAMMATION;
   DYSFUNCTION
AB Endocrine disorders have become more and more frequently diagnosed in humans and animals. In horses, equine metabolic syndrome (EMS) is characterized by insulin resistance, hyperleptinemia, hyperinsulinemia, inflammation and usually by pathological obesity. Due to an increased inflammatory response in the adipose tissue, cytophysiological properties of adipose derived stem cells (ASC) have been impaired, which strongly limits their therapeutic potential. Excessive accumulation of reactive oxygen species, mitochondria deterioration and accelerated ageing of those cells affect their multipotency and restrict the effectiveness of the differentiation process. In the present study, we have treated ASC isolated from EMS individuals with a combination of 5-azacytydine (AZA) and resveratrol (RES) in order to reverse their aged phenotype and enhance osteogenic differentiation. Using SEM and confocal microscope, cell morphology, matrix mineralization and mitochondrial dynamics were assessed. Furthermore, we investigated the expression of osteogenic-related genes with RT-PCR. We also investigated the role of autophagy during differentiation and silenced PARKIN expression with siRNA. Obtained results indicated that AZA/RES significantly enhanced early osteogenesis of ASC derived from EMS animals. Increased matrix mineralization, RUNX-2, collagen type I and osteopontin levels were noted. Furthermore, we proved that AZA/RES exerts its beneficial effects by modulating autophagy and mitochondrial dynamics through PARKIN and RUNX-2 activity.
C1 [Marycz, Krzysztof; Kornicka, Katarzyna] Wroclaw Univ Environm & Life Sci, Dept Expt Biol, Wroclaw, Poland.
   [Marycz, Krzysztof] Wroclaw Res Ctr EIT, Wroclaw, Poland.
   [Irwin-Houston, Jennifer M.; Weiss, Christine] PferdePraxis Dr Med Vet Daniel Weiss, Freienbach, Switzerland.
C3 Wroclaw University of Environmental & Life Sciences
RP Marycz, K (corresponding author), Wroclaw Univ Environm & Life Sci, Dept Expt Biol, Wroclaw, Poland.; Marycz, K (corresponding author), Wroclaw Res Ctr EIT, Wroclaw, Poland.
EM krzysztofmarycz@interia.pl
FU Narodowe Centrum Nauki [2016/21/B/NZ7/01111]
FX Narodowe Centrum Nauki, Grant/Award Number: 2016/21/B/NZ7/01111
CR Basinska K, 2015, J VET SCI, V16, P113, DOI [10.4142/jvs.2015.16.1.113, 10.4142/jvs.2015.16.1.107]
   Bhullar KS, 2015, BBA-MOL BASIS DIS, V1852, P1209, DOI 10.1016/j.bbadis.2015.01.012
   Calabrese R, 2014, BBA-MOL BASIS DIS, V1842, P1130, DOI 10.1016/j.bbadis.2014.04.010
   Carpio LR, 2016, SCI SIGNAL, V9, DOI 10.1126/scisignal.aaf3273
   Cheng PW, 2014, BRIT J PHARMACOL, V171, P2739, DOI 10.1111/bph.12648
   Chestnut BA, 2011, J NEUROSCI, V31, P16619, DOI 10.1523/JNEUROSCI.1639-11.2011
   CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1006/abio.1987.9999
   Cimmino L, 2017, CELL, V170, P1079, DOI 10.1016/j.cell.2017.07.032
   Coelho M, 2013, ARCH MED SCI, V9, P191, DOI 10.5114/aoms.2013.33181
   de Laat MA, 2012, VET IMMUNOL IMMUNOP, V145, P395, DOI 10.1016/j.vetimm.2011.12.016
   Frank N, 2010, J VET INTERN MED, V24, P467, DOI 10.1111/j.1939-1676.2010.0503.x
   Frank N, 2009, J EQUINE VET SCI, V29, P259, DOI 10.1016/j.jevs.2009.04.183
   Gan KX, 2013, WORLD J GASTROENTERO, V19, P1572, DOI 10.3748/wjg.v19.i10.1572
   Geor RJ, 2008, J EQUINE VET SCI, V28, P753, DOI 10.1016/j.jevs.2008.10.016
   González MA, 2009, ARTHRITIS RHEUM-US, V60, P1006, DOI 10.1002/art.24405
   Gülçin I, 2010, INNOV FOOD SCI EMERG, V11, P210, DOI 10.1016/j.ifset.2009.07.002
   Hernandez DG, 2011, HUM MOL GENET, V20, P1164, DOI 10.1093/hmg/ddq561
   Huang SS, 2017, SCI REP-UK, V7, DOI 10.1038/srep45692
   Hurley DJ, 2006, VET IMMUNOL IMMUNOP, V110, P195, DOI 10.1016/j.vetimm.2005.09.015
   Kao CL, 2010, STEM CELLS DEV, V19, P247, DOI 10.1089/scd.2009.0186
   Klöting N, 2014, REV ENDOCR METAB DIS, V15, P277, DOI 10.1007/s11154-014-9301-0
   Kornicka K, 2017, RSC ADV, V7, P24070, DOI 10.1039/c7ra02334k
   Kornicka K, 2017, J CELL MOL MED, V21, P387, DOI 10.1111/jcmm.12972
   Kornicka K, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/309169
   Lastra G, 2013, HORM MOL BIOL CLIN I, V15, P49, DOI 10.1515/hmbci-2013-0025
   Liu LF, 2015, DIABETOLOGIA, V58, P1579, DOI 10.1007/s00125-015-3603-y
   Manna P, 2015, METAB SYNDR RELAT D, V13, P423, DOI 10.1089/met.2015.0095
   Maredziak M, 2015, IN VITRO CELL DEV-AN, V51, P230, DOI 10.1007/s11626-014-9828-0
   Marycz K, 2012, VET MED-CZECH, V57, P610, DOI 10.17221/6469-VETMED
   Marycz K, 2016, OXID MED CELL LONGEV, V2016, P2384
   Marycz K, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19010165
   Marycz K, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/4710326
   Marycz K, 2016, J CELL MOL MED, V20, P2384, DOI 10.1111/jcmm.12932
   Matsuzaki S, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0123578
   Momparler RL, 2014, CLIN EPIGENETICS, V6, DOI 10.1186/1868-7083-6-19
   Morselli E, 2010, CELL DEATH DIS, V1, DOI 10.1038/cddis.2009.8
   Muralidharan-Chari V, 2010, J CELL SCI, V123, P1603, DOI 10.1242/jcs.064386
   Nishimura Satoshi, 2009, Discov Med, V8, P55
   Owens SD, 2016, STEM CELLS INT, V2016, DOI 10.1155/2016/5830103
   Peng JY, 2011, PLOS COMPUT BIOL, V7, DOI 10.1371/journal.pcbi.1002212
   Pileggi A, 2012, DIABETES, V61, P1355, DOI 10.2337/db12-0355
   Puissant A, 2010, CANCER RES, V70, P1042, DOI 10.1158/0008-5472.CAN-09-3537
   Ratajczak J, 2006, LEUKEMIA, V20, P1487, DOI 10.1038/sj.leu.2404296
   Ren XC, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/4175353
   Robb EL, 2017, BIOCHEM BIOPH RES CO, V485, P249, DOI 10.1016/j.bbrc.2017.02.102
   Rovira-Llopis S, 2017, REDOX BIOL, V11, P637, DOI 10.1016/j.redox.2017.01.013
   Seeliger C, 2013, CELL TRANSPLANT, V22, P119, DOI 10.3727/096368912X638946
   Shakibaei M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035712
   Spanier G, 2009, J PHYSIOL PHARMACOL, V60, P111
   Suszynska M, 2014, J OVARIAN RES, V7, DOI 10.1186/1757-2215-7-66
   Svajger U, 2012, INT REV IMMUNOL, V31, P202, DOI 10.3109/08830185.2012.665108
   Yang J, 2014, ANDROLOGIA, V46, P522, DOI 10.1111/and.12108
   Zhang JY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0073086
NR 53
TC 21
Z9 23
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD OCT
PY 2018
VL 22
IS 10
BP 4771
EP 4793
DI 10.1111/jcmm.13731
PG 23
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA GU8TX
UT WOS:000445616300020
PM 29999247
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Maksyutynska, K
   Stogios, N
   Prasad, F
   Gill, J
   Hamza, Z
   De, R
   Smith, E
   Horta, A
   Goldstein, BI
   Korczak, D
   Graff-Guerrero, A
   Hahn, MK
   Agarwal, SM
AF Maksyutynska, Kateryna
   Stogios, Nicolette
   Prasad, Femin
   Gill, Jashan
   Hamza, Zaineb
   De, Riddhita
   Smith, Emily
   Horta, Angelina
   Goldstein, Benjamin I.
   Korczak, Daphne
   Graff-Guerrero, Ariel
   Hahn, Margaret K.
   Agarwal, Sri Mahavir
TI Neurocognitive correlates of metabolic dysregulation in individuals with
   mood disorders: a systematic review and meta-analysis
SO PSYCHOLOGICAL MEDICINE
LA English
DT Review; Early Access
DE attention; bipolar disorder; cognition; diabetes; executive function;
   insulin resistance; major depressive disorder; memory; metabolic
   syndrome; mood disorders; obesity; processing speed
ID MAJOR DEPRESSIVE DISORDER; LATE-LIFE DEPRESSION; BIPOLAR I DISORDER;
   BODY-MASS INDEX; COGNITIVE IMPAIRMENT; DIABETES-MELLITUS; CLINICAL
   CHARACTERISTICS; INSULIN-RESISTANCE; EXECUTIVE FUNCTION; OLDER-ADULTS
AB Individuals with mood disorders are predisposed to metabolic dysfunction, while those with metabolic dysregulation such as diabetes and obesity experience more severe depressive symptoms. Both metabolic dysfunction and mood disorders are independently associated with cognitive deficits. Therefore, given their close association, this study aimed to explore the association between metabolic dysfunction in individuals with mood disorders in relation to cognitive outcomes. A comprehensive search comprised of these three domains was carried out; a random-effects meta-analysis pooling mean cognitive outcomes was conducted (PROSPERO ID: CRD42022295765). Sixty-three studies were included in this review; 26 were synthesized in a quantitative meta-analysis. Comorbid metabolic dysregulation was associated with significantly lower global cognition among individuals with mood disorders. These trends were significant within each mood disorder subgroup, including major depressive disorder, bipolar disorder, and self-report depression/depressive symptoms. Type 2 diabetes was associated with the lowest cognitive performance in individuals with mood disorders, followed by peripheral insulin resistance, body mass index >= 25 kg/m(2), and metabolic syndrome. Significant reduction in scores was also observed among individual cognitive domains (in descending order) of working memory, attention, executive function, processing speed, verbal memory, and visual memory. These findings demonstrate the detrimental effects of comorbid metabolic dysfunction in individuals with mood disorders. Further research is required to understand the underlying mechanisms connecting mood disorders, metabolism, and cognition.
C1 [Maksyutynska, Kateryna; Stogios, Nicolette; Prasad, Femin; Gill, Jashan; Hamza, Zaineb; De, Riddhita; Smith, Emily; Horta, Angelina; Goldstein, Benjamin I.; Korczak, Daphne; Graff-Guerrero, Ariel; Hahn, Margaret K.; Agarwal, Sri Mahavir] Univ Toronto, Inst Med Sci, Toronto, ON, Canada.
   [Maksyutynska, Kateryna; Stogios, Nicolette; Prasad, Femin; De, Riddhita; Smith, Emily; Hahn, Margaret K.; Agarwal, Sri Mahavir] Ctr Addict & Mental Hlth, Schizophrenia Div, Toronto, ON, Canada.
   [Gill, Jashan] McMaster Univ, Fac Sci, Hamilton, ON, Canada.
   [Hamza, Zaineb; Horta, Angelina] McMaster Univ, Fac Hlth Sci, Hamilton, ON, Canada.
   [Goldstein, Benjamin I.; Korczak, Daphne; Graff-Guerrero, Ariel; Hahn, Margaret K.; Agarwal, Sri Mahavir] Univ Toronto, Fac Med, Dept Psychiat, Toronto, ON, Canada.
   [Goldstein, Benjamin I.] Ctr Addict & Mental Hlth, Ctr Youth Bipolar Disorder, Toronto, ON, Canada.
   [Goldstein, Benjamin I.] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada.
   [Korczak, Daphne] Hosp Sick Children, Dept Psychiat, Toronto, ON, Canada.
   [Graff-Guerrero, Ariel] Ctr Addict & Mental Hlth, Res Imaging Ctr, Toronto, ON, Canada.
C3 University of Toronto; University of Toronto; Centre for Addiction &
   Mental Health - Canada; McMaster University; McMaster University;
   University of Toronto; University of Toronto; Centre for Addiction &
   Mental Health - Canada; University of Toronto; University of Toronto;
   Hospital for Sick Children (SickKids); University of Toronto; Centre for
   Addiction & Mental Health - Canada
RP Agarwal, SM (corresponding author), Univ Toronto, Inst Med Sci, Toronto, ON, Canada.; Agarwal, SM (corresponding author), Ctr Addict & Mental Hlth, Schizophrenia Div, Toronto, ON, Canada.; Agarwal, SM (corresponding author), Univ Toronto, Fac Med, Dept Psychiat, Toronto, ON, Canada.
EM Mahavir.Agarwal@camh.ca
RI Agarwal, Mahavir/ITV-3244-2023; Goldstein, Benjamin/ADR-2374-2022
OI De, Riddhita/0000-0002-8953-4716; Stogios, Nicolette/0000-0001-9136-4923
FU Academic Scholars Award from the Department of Psychiatry, University of
   Toronto; CAMH Discovery Fund; RBC Investments Chair in Children's Mental
   Health and Developmental Psychopathology at CAMH; University of Toronto,
   CAMH; CAMH Foundation
FX The authors would like to thank Dr Van Rheenen et al., Dr Hubenak et
   al., and Dr Geraets et al. for providing additional information to
   synthesize in this review. S. M. A. is supported by in part by an
   Academic Scholars Award from the Department of Psychiatry, University of
   Toronto and the CAMH Discovery Fund. B. I. G. acknowledges his position
   as RBC Investments Chair in Children's Mental Health and Developmental
   Psychopathology at CAMH, a joint Hospital-University Chair between the
   University of Toronto, CAMH, and the CAMH Foundation.
CR Bai YM, 2016, BMC PSYCHIATRY, V16, DOI 10.1186/s12888-016-1143-8
   Beunders AJM, 2021, ACTA PSYCHIAT SCAND, V144, P392, DOI 10.1111/acps.13342
   Bond DJ, 2017, ACTA PSYCHIAT SCAND, V135, P239, DOI 10.1111/acps.12674
   Bora E, 2017, PSYCHOL MED, V47, P1030, DOI 10.1017/S0033291716003366
   Bora E, 2019, PSYCHOL MED, V49, P738, DOI 10.1017/S0033291718003008
   Borhaninejad V, 2022, ACTA FAC MEDICAE NAI, V39, P85, DOI 10.5937/afmnai39-34820
   Burdick KE, 2010, ACTA PSYCHIAT SCAND, V122, P499, DOI 10.1111/j.1600-0447.2010.01590.x
   Cao F, 2023, FRONT AGING NEUROSCI, V15, DOI 10.3389/fnagi.2023.1081393
   Chang HH, 2022, CNS SPECTRUMS, V27, P598, DOI 10.1017/S1092852921000158
   Chang TT, 2015, PSYCHOGERIATRICS, V15, P109, DOI 10.1111/psyg.12080
   Chen MH, 2021, CNS SPECTRUMS, V26, P521, DOI 10.1017/S1092852920001534
   Chen ST, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0098630
   Choi DW, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-44158-7
   Chow YY, 2022, DIABETES RES CLIN PR, V185, DOI 10.1016/j.diabres.2022.109227
   Corréard N, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184313
   Cramer V, 2010, NORD J PSYCHIAT, V64, P58, DOI 10.3109/08039480903287565
   Cutler RL, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2017-016982
   Dalkner N, 2021, FRONT NEUROSCI-SWITZ, V15, DOI 10.3389/fnins.2021.717824
   Dalkner N, 2021, NEUROPSYCHOBIOLOGY, V80, P1, DOI 10.1159/000505784
   Demakakos P, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0175827
   Dennis M, 2009, J INT NEUROPSYCH SOC, V15, P331, DOI 10.1017/S1355617709090481
   Depp CA, 2014, BIPOLAR DISORD, V16, P422, DOI 10.1111/bdi.12200
   Downer B, 2016, J AM GERIATR SOC, V64, P109, DOI 10.1111/jgs.13883
   Ferri F, 2021, AGING MENT HEALTH, V25, P2003, DOI 10.1080/13607863.2020.1792412
   Fourrier C, 2020, BRAIN BEHAV IMMUN, V88, P242, DOI 10.1016/j.bbi.2020.06.007
   Frey BN, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.20213
   Geraets AFJ, 2022, J AFFECT DISORDERS, V313, P110, DOI 10.1016/j.jad.2022.06.045
   Borda MG, 2019, EUR GERIATR MED, V10, P413, DOI 10.1007/s41999-019-00185-1
   Guan LY, 2021, J PSYCHIATR RES, V143, P580, DOI 10.1016/j.jpsychires.2020.11.022
   Guo M, 2014, CLIN EXP PHARMACOL P, V41, P650, DOI 10.1111/1440-1681.12265
   Hamer JA, 2019, EXP NEUROL, V315, P1, DOI 10.1016/j.expneurol.2019.01.016
   Hidese S, 2018, J AFFECT DISORDERS, V225, P188, DOI 10.1016/j.jad.2017.08.028
   Hubenak J, 2015, NEUROENDOCRINOL LETT, V36, P294
   Hui L, 2019, INT J BIPOLAR DISORD, V7, DOI 10.1186/s40345-019-0159-7
   Janocha A, 2010, NEUROENDOCRINOL LETT, V31, P399
   Jia QF, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-77782-9
   Johar H, 2023, PREV MED, V167, DOI 10.1016/j.ypmed.2022.107390
   Kadriu B, 2024, BIPOLAR DISORD, V26, P160, DOI 10.1111/bdi.13370
   Karlsson IK, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-86667-4
   Kloiber S, 2007, BIOL PSYCHIAT, V62, P321, DOI 10.1016/j.biopsych.2006.10.001
   Kontari P, 2019, INT J GERIATR PSYCH, V34, P289, DOI 10.1002/gps.5019
   Kopchak Oksana, 2017, Wiad Lek, V70, P737
   Korczak DJ, 2011, DIABETOLOGIA, V54, P2483, DOI 10.1007/s00125-011-2240-3
   Kraus C, 2023, J AFFECT DISORDERS, V335, P349, DOI 10.1016/j.jad.2023.05.042
   La Montagna M, 2017, EUR PSYCHIAT, V41, pS207, DOI 10.1016/j.eurpsy.2017.01.2167
   Lackner N, 2016, WORLD J BIOL PSYCHIA, V17, P535, DOI 10.3109/15622975.2015.1046917
   Lan XF, 2022, J AFFECT DISORDERS, V313, P118, DOI 10.1016/j.jad.2022.06.073
   Li CT, 2015, PSYCHONEUROENDOCRINO, V55, P72, DOI 10.1016/j.psyneuen.2015.02.003
   Liebing S, 2023, J AFFECT DISORDERS, V323, P251, DOI 10.1016/j.jad.2022.11.067
   Lin QM, 2022, CHILD ADOL PSYCH MEN, V16, DOI 10.1186/s13034-022-00468-9
   Liu ZR, 2023, GERONTOLOGY, V69, P899, DOI 10.1159/000530200
   Mann EM, 2022, BMC PUBLIC HEALTH, V22, DOI 10.1186/s12889-022-12905-7
   Mansur RB, 2020, BIPOLAR DISORD, V22, P79, DOI 10.1111/bdi.12826
   Mansur RB, 2017, J AFFECT DISORDERS, V207, P114, DOI 10.1016/j.jad.2016.09.056
   Mansur RB, 2015, NEUROSCI BIOBEHAV R, V52, P89, DOI 10.1016/j.neubiorev.2014.12.017
   Marijnissen RM, 2017, PSYCHOL MED, V47, P1041, DOI 10.1017/S0033291716003196
   Martinez-Aran A, 2009, J CLIN PSYCHIAT, V70, P1017, DOI 10.4088/JCP.08m04408
   Marvel CL, 2004, PSYCHIAT CLIN N AM, V27, P19, DOI 10.1016/S0193-953X(03)00106-0
   McIntyre RS, 2015, J AFFECT DISORDERS, V172, P259, DOI 10.1016/j.jad.2014.09.026
   Mehra A, 2022, INDIAN JOURNAL OF PSYCHIATRY, V64
   Modesti PA, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0147601
   Mohammed SH, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-028238
   Mora E, 2017, J CLIN PSYCHIAT, V78, pE924, DOI 10.4088/JCP.16m10968
   Naiberg MR, 2016, ACTA PSYCHIAT SCAND, V134, P241, DOI 10.1111/acps.12603
   Naiberg MR, 2016, J PSYCHIATR RES, V83, P230, DOI 10.1016/j.jpsychires.2016.08.019
   Ng TP, 2009, J AM GERIATR SOC, V57, P1058, DOI 10.1111/j.1532-5415.2009.02262.x
   Page MJ, 2021, BMJ-BRIT MED J, V372, DOI [10.1136/bmj.n71, 10.1136/bmj.n160]
   Péterfalvi A, 2019, FRONT PSYCHOL, V10, DOI 10.3389/fpsyg.2019.01798
   Pillinger T, 2020, LANCET PSYCHIAT, V7, P64, DOI 10.1016/S2215-0366(19)30416-X
   Qiu WX, 2021, FRONT NEUROSCI-SWITZ, V15, DOI 10.3389/fnins.2021.728810
   Qiu Y, 2022, J AFFECT DISORDERS, V297, P477, DOI 10.1016/j.jad.2021.10.100
   Quintana DS, 2023, ADV METH PRACT PSYCH, V6, DOI 10.1177/25152459221147260
   Reininghaus B, 2022, NUTRIENTS, V14, DOI 10.3390/nu14061176
   Restivo MR, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0176898
   Ringin E., 2023, Relative associations of behavioural and physiological risks for cardiometabolic disease with cognition in bipolar disorder: Findings from the UK Biobank, DOI [10.31234/osf.io/gpnmd, DOI 10.31234/OSF.IO/GPNMD]
   Ringin E, 2023, NEUROPSYCHOPHARMACOL, V48, P362, DOI 10.1038/s41386-022-01471-6
   Roy T, 2012, J AFFECT DISORDERS, V142, pS8, DOI 10.1016/S0165-0327(12)70004-6
   Salvi V, 2020, J AFFECT DISORDERS, V266, P610, DOI 10.1016/j.jad.2020.01.145
   Scuteri A, 2011, ARCH GERONTOL GERIAT, V52, P253, DOI 10.1016/j.archger.2010.04.002
   Shao TN, 2017, COMPR PSYCHIAT, V75, P103, DOI 10.1016/j.comppsych.2017.03.007
   Siegel-Ramsay J. E., 2022, Journal of Affective Disorders Reports, V10, DOI [10.1016/j.jadr.2022.100442, DOI 10.1016/J.JADR.2022.100442]
   Silveira LE, 2014, CAN J PSYCHIAT, V59, P639, DOI 10.1177/070674371405901205
   Singh MK, 2019, HORM BEHAV, V108, P73, DOI 10.1016/j.yhbeh.2018.03.009
   Smith PJ, 2018, AM J GERIAT PSYCHIAT, V26, P1061, DOI 10.1016/j.jagp.2018.06.011
   Tsai SY, 2007, BIPOLAR DISORD, V9, P868, DOI 10.1111/j.1399-5618.2007.00498.x
   Van Rheenen TE, 2021, J AFFECT DISORDERS, V278, P556, DOI 10.1016/j.jad.2020.09.104
   Wang AY, 2023, JPAD-J PREV ALZHEIM, V10, P83, DOI 10.14283/jpad.2022.81
   Wei JK, 2019, J PSYCHIATR RES, V111, P30, DOI 10.1016/j.jpsychires.2019.01.012
   Wroolie TE, 2015, J PSYCHIATR RES, V60, P65, DOI 10.1016/j.jpsychires.2014.10.001
   Yim CY, 2012, EUR PSYCHIAT, V27, P223, DOI 10.1016/j.eurpsy.2011.02.004
   Zhang XY, 2021, J AFFECT DISORDERS, V290, P387, DOI 10.1016/j.jad.2021.04.092
   Zhuo CJ, 2022, FRONT PSYCHIATRY, V13, DOI 10.3389/fpsyt.2022.880031
NR 92
TC 7
Z9 7
U1 6
U2 21
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD 2024 MAR 7
PY 2024
DI 10.1017/S0033291724000345
EA MAR 2024
PG 27
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA MJ1E6
UT WOS:001193154900001
PM 38450447
OA hybrid
DA 2025-06-11
ER

PT J
AU Morán-Ramos, S
   Avila-Nava, A
   Tovar, AR
   Pedraza-Chaverri, J
   Lopez-Romero, P
   Torres, N
AF Moran-Ramos, Sofia
   Avila-Nava, Azalia
   Tovar, Armando R.
   Pedraza-Chaverri, Jose
   Lopez-Romero, Patricia
   Torres, Nimbe
TI Opuntia ficus indica (Nopal) Attenuates Hepatic Steatosis and
   Oxidative Stress in Obese Zucker (fa/fa) Rats
SO JOURNAL OF NUTRITION
LA English
DT Article
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; METABOLIC SYNDROME; INDUCED
   NEPHROTOXICITY; ADIPONECTIN RECEPTORS; SOY PROTEIN; STEATOHEPATITIS;
   MODELS; BLOOD; FIBER
AB Nonalcoholic fatty liver disease (NAFLD) is associated with multiple factors such as obesity, insulin resistance, and oxidative stress. Nopal, a cactus plant widely consumed in the Mexican diet, is considered a functional food because of its antioxidant activity and ability to improve biomarkers of metabolic syndrome. The aim of this study was to assess the effect of nopal consumption on the development of hepatic steatosis and hepatic oxidative stress and on the regulation of genes involved in hepatic lipid metabolism. Obese Zucker (fa/fa) rats were fed a control diet or a diet containing 4% nopal for 7 wk. Rats fed the nopal-containing diet had similar to 50% lower hepatic TG than the control group as well as a reduction in hepatomegaly and biomarkers of hepatocyte injury such as alanine and aspartate aminotransferases. Attenuation of hepatic steatosis by nopal consumption was accompanied by a higher serum concentration of adiponectin and a greater abundance of mRNA for genes involved in lipid oxidation and lipid export and production of carnitine palmitoyltransferase-1 and microsomal TG transfer proteins in liver. Hepatic reactive oxygen species and lipid peroxidation biomarkers were significantly lower in rats fed nopal compared with the control rats. Furthermore, rats fed the nopal diet had a lower postprandial serum insulin concentration and a greater liver phosphorylated protein kinase B (pAKT):AKT ratio in the postprandial state. This study suggests that nopal consumption attenuates hepatic steatosis by increasing fatty acid oxidation and VLDL synthesis, decreasing oxidative stress, and improving liver insulin signaling in obese Zucker (fa/fa) rats. J. Nutr. 142: 1956-1963, 2012.
C1 [Moran-Ramos, Sofia; Tovar, Armando R.; Lopez-Romero, Patricia; Torres, Nimbe] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Fisiol Nutr, Mexico City, DF, Mexico.
   [Avila-Nava, Azalia; Pedraza-Chaverri, Jose] Univ Nacl Autonoma Mexico, Fac Quim, Dept Biol, Mexico City 04510, DF, Mexico.
   [Moran-Ramos, Sofia] Univ Nacl Autonoma Mexico, Fac Med, Mexico City 04510, DF, Mexico.
C3 Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico; Universidad Nacional Autonoma de Mexico; Universidad Nacional
   Autonoma de Mexico
RP Torres, N (corresponding author), Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Fisiol Nutr, Mexico City, DF, Mexico.
EM nimbester@gmail.com
RI Moran, Sofia/AAK-8815-2021; Torres, Nimbe/AAI-4340-2020
OI Avila-Nava, Azalia/0000-0003-3363-1477
FU Instituto Nacional de Ciencia y Tecnologia del D.F. [PICDS08-6]; Grupo
   Produce del D.F; Programa de Apoyo a Proyectos de Investigacion e
   Innovacion Tecnologica [IN201910]; Consejo Nacional de Ciencia y
   Tecnologi (CONACYT) [129838]; CONACYT
FX Supported in part by Instituto Nacional de Ciencia y Tecnologia del D.F.
   grant PICDS08-6 (N.T.) and Grupo Produce del D.F (N.T.), Programa de
   Apoyo a Proyectos de Investigacion e Innovacion Tecnologica IN201910
   (J.P.-C.) and Consejo Nacional de Ciencia y Tecnologi (CONACYT) 129838
   (J.P.-C.). S.M.-R. and A.A.-N. received scholarships from CONACYT.
CR de Artiñano AA, 2009, BRIT J NUTR, V102, P1246, DOI 10.1017/S0007114509990729
   Association of Official Analytical Chemists International, 2010, OFFICIAL METHODS ANA
   Browning JD, 2004, HEPATOLOGY, V40, P1387, DOI 10.1002/hep.20466
   Browning JD, 2004, J CLIN INVEST, V114, P147, DOI 10.1172/JCI200422422
   Buqué X, 2010, J LIPID RES, V51, P500, DOI 10.1194/jlr.M001966
   Cave M, 2007, J NUTR BIOCHEM, V18, P184, DOI 10.1016/j.jnutbio.2006.12.006
   CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1006/abio.1987.9999
   Cohen JC, 2011, SCIENCE, V332, P1519, DOI 10.1126/science.1204265
   Dowman JK, 2011, DIABETES OBES METAB, V13, P692, DOI 10.1111/j.1463-1326.2011.01403.x
   ESSER V, 1993, J BIOL CHEM, V268, P5810
   Forcheron F, 2009, OBESITY, V17, P1381, DOI 10.1038/oby.2008.661
   Frezza C, 2007, NAT PROTOC, V2, P287, DOI 10.1038/nprot.2006.478
   Frigolet ME, 2011, J NUTR BIOCHEM, V22, P118, DOI 10.1016/j.jnutbio.2009.12.006
   Ginestra G, 2009, J AGR FOOD CHEM, V57, P10323, DOI 10.1021/jf9022096
   Guevara-Cruz M, 2012, J NUTR, V142, P64, DOI 10.3945/jn.111.147447
   Kadowaki T, 2006, J CLIN INVEST, V116, P1784, DOI 10.1172/JCI29126
   Koren E, 2010, EXP BIOL MED, V235, P689, DOI 10.1258/ebm.2010.009370
   Koteish A, 2001, SEMIN LIVER DIS, V21, P89, DOI 10.1055/s-2001-12932
   Ludwig J, 1997, J GASTROEN HEPATOL, V12, P398, DOI 10.1111/j.1440-1746.1997.tb00450.x
   Medina-Torres L, 2011, J SCI FOOD AGR, V91, P1001, DOI 10.1002/jsfa.4271
   Musso G, 2009, PROG LIPID RES, V48, P1, DOI 10.1016/j.plipres.2008.08.001
   Okuno A, 1998, J CLIN INVEST, V101, P1354, DOI 10.1172/JCI1235
   Orozco-Ibarra M, 2007, TOXICOLOGY, V229, P123, DOI 10.1016/j.tox.2006.10.008
   Otvos James D, 2002, Clin Lab, V48, P171
   Pan MH, 2004, J CLIN INVEST, V113, P1277, DOI 10.1172/JCI200419197
   Parnell JA, 2012, LIVER INT, V32, P701, DOI 10.1111/j.1478-3231.2011.02730.x
   Pérez-Rojas JM, 2011, FOOD CHEM TOXICOL, V49, P2631, DOI 10.1016/j.fct.2011.07.008
   Pfaffl MW, 2001, NUCLEIC ACIDS RES, V29, DOI 10.1093/nar/29.9.e45
   Reeves PG, 1997, J NUTR, V127, pS838
   Rodríguez-Garcia ME, 2007, PLANT FOOD HUM NUTR, V62, P107, DOI 10.1007/s11130-007-0049-5
   Santos-Zea L, 2011, J AGR FOOD CHEM, V59, P7054, DOI 10.1021/jf200944y
   Serkova NJ, 2006, J HEPATOL, V44, P956, DOI 10.1016/j.jhep.2005.07.009
   Stintzing FC, 2005, MOL NUTR FOOD RES, V49, P175, DOI 10.1002/mnfr.200400071
   Tomita K, 2004, AM J PHYSIOL-GASTR L, V287, pG1078, DOI 10.1152/ajpgi.00107.2004
   Tovar AR, 2005, J LIPID RES, V46, P1823, DOI 10.1194/jlr.M500067-JLR200
   Utzschneider KM, 2006, J CLIN ENDOCR METAB, V91, P4753, DOI 10.1210/jc.2006-0587
   VAHOUNY GV, 1988, AM J CLIN NUTR, V47, P201, DOI 10.1093/ajcn/47.2.201
   Yamauchi T, 2003, NATURE, V423, P762, DOI 10.1038/nature01705
NR 38
TC 58
Z9 62
U1 0
U2 26
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3166
J9 J NUTR
JI J. Nutr.
PD NOV
PY 2012
VL 142
IS 11
BP 1956
EP 1963
DI 10.3945/jn.112.165563
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 028IQ
UT WOS:000310416400006
PM 23014486
OA Bronze
DA 2025-06-11
ER

PT J
AU Van Gaal, L
   Pt-Sunyer, X
   Després, JP
   McCarthy, C
   Scheen, A
AF Van Gaal, Luc
   Pt-Sunyer, Xavier
   Despres, Jean-Pierre
   McCarthy, Christine
   Scheen, Andre
TI Efficacy and Safety of Rimonabant for Improvement of Multiple
   Cardiometabolic Risk Factors in Overweight/Obese patients Pooled 1-year
   data from the Rimonabant in Obesity (RIO) program
SO DIABETES CARE
LA English
DT Article; Proceedings Paper
CT 1st Meeting on Controversies in Obesity, Diabetes and Hypertension
CY OCT, 2006
CL Berlin, GERMANY
ID CANNABINOID-1 RECEPTOR BLOCKER; ENDOCANNABINOID SYSTEM; METABOLIC
   SYNDROME; GLUCOSE-TOLERANCE; WEIGHT-REDUCTION; HOSPITAL ANXIETY;
   ADIPOSE-TISSUE; DYSREGULATION; ACTIVATION; INSULIN
AB OBJECTIVE- To better define the efficacy and safety of rimonabant, the first selective cannabinoid type 1 (CB1) receptor antagonist, in a large population of overweight and obese patients using pooled efficacy data from three Phase III nondiabetes Rimonabant, in Obesity and Related Metabolic Disorders (RIO) studies, selected efficacy data from the RIO-Diabetes study, and pooled safety data for all four RIO studies.
   RESEARCH DESIGN AND METHODS - The RIO studies enrolled patients who were either overweight (BMI >27 kg/m(2)) with at least one comorbidity (i.e., hypertension, dyslipidemia, or, for RIO-Diabetes, type 2 diabetes) or obese. All patient, received daily treatment with rimonabant (5 or 20 mg) or placebo for 1 year plus a hypocaloric diet (600 kcal/day deficit) and advice on increased physical activity. RIO-Europe (n = 1,508), RIO-North America (n = 3,045), and RIO-Lipids (n = 1,036) excluded patients with type 2 diabetes; untreated dyslipidemia was art entry requirement for RIO-Lipids. RIO-Diabetes (n - 1,047) required the presence of type 2 diabetes inadequately controlled by sulfonylurea or metformin monotherapy.
   RESULTS - The pooled intention-to-treat population comprised 5,580 patients without diabetes (3,165 completed treatment) and 1,047 patients with diabetes (692 completed treatment). Most efficacy measures improved during the 4-week placebo run-in period, except that HDL cholesterol decreased as expected in the early phase of a hypocaloric diet. After 1 year of randomized treatment, changes from baseline with 20 mg rimonabant in the nondiabetic population were as follows: body weight -6.5 kg, waist circumference -6.4 cm, HDL cholesterol +16.4%, triglycerides -6.9%, fasting insulin -0.6 mu U/ml, and homeostasis model assessment for insulin resistance (HOMA-IR) -0.2 (all P < 0.001 vs. placebo). In the diabetic population, 20 mg rimonabant reduced A1C levels by 06% (P < 0.001 vs. placebo). Regression analysis of change in HDL cholesterol, triglycerides, adiponectin (in RIO-Lipids), and A1C (in RIO-Diabetes) versus body weight at 1 year by ANCOVA suggested that 45-57% of the effect of rimonabant could not be explained by the observed weight loss. At 1 year, adverse events more
C1 [Van Gaal, Luc] Univ Antwerp Hosp, Fac Med, Dept Diabet Metab & Clin Nutr, B-2650 Edegem, Belgium.
   [Pt-Sunyer, Xavier] St Lukes Roosevelt Hosp, New York, NY USA.
   [McCarthy, Christine] Sanofi Aventis, Chilly Mazarn, France.
   [Scheen, Andre] Univ Liege, CHU Sart Tilman, Div Diabet Nutr & Metab Disorders, Liege, Belgium.
   [Despres, Jean-Pierre] Univ Laval, Laval Hosp Res Ctr, Quebec Heart Inst, Ste Foy, PQ G1K 7P4, Canada.
C3 University of Antwerp; Mount Sinai St. Luke's; Mount Sinai West;
   Sanofi-Aventis; University of Liege; Laval University
RP Van Gaal, L (corresponding author), Univ Antwerp Hosp, Fac Med, Dept Diabet Metab & Clin Nutr, Wilrijkstr 10, B-2650 Edegem, Belgium.
EM luc.van.gaal@uza.be
CR *ACOMPLIA, ACOMPLIA SUMM PROD C
   Bensaid M, 2003, MOL PHARMACOL, V63, P908, DOI 10.1124/mol.63.4.908
   Blüher M, 2006, DIABETES, V55, P3053, DOI 10.2337/db06-0812
   Cota D, 2003, J CLIN INVEST, V112, P423, DOI 10.1172/JCI17725
   Côté M, 2007, INT J OBESITY, V31, P692, DOI 10.1038/sj.ijo.0803539
   DATTILO AM, 1992, AM J CLIN NUTR, V56, P320, DOI 10.1093/ajcn/56.2.320
   Després JP, 2006, ATHEROSCLEROSIS SUPP, V7, P329, DOI 10.1016/S1567-5688(06)81311-5
   Despres JP, 2006, DIABETES, V55, pA80
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Despres JP, 2005, NEW ENGL J MED, V353, P2121, DOI 10.1056/NEJMoa044537
   Després JP, 2001, BMJ-BRIT MED J, V322, P716, DOI 10.1136/bmj.322.7288.716
   Douketis JD, 2005, INT J OBESITY, V29, P1153, DOI 10.1038/sj.ijo.0802982
   Engeli S, 2005, DIABETES, V54, P2838, DOI 10.2337/diabetes.54.10.2838
   *FDA, 2007, FDA ADV COMM M 10 MA
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Gary-Bobo M, 2007, HEPATOLOGY, V46, P122, DOI 10.1002/hep.21641
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Herrmann C, 1997, J PSYCHOSOM RES, V42, P17, DOI 10.1016/S0022-3999(96)00216-4
   HOCHBERG Y, 1988, BIOMETRIKA, V75, P800, DOI 10.2307/2336325
   Izzo AA, 2001, BRIT J PHARMACOL, V134, P563, DOI 10.1038/sj.bjp.0704293
   Juan-Picó P, 2006, CELL CALCIUM, V39, P155, DOI 10.1016/j.ceca.2005.10.005
   Kirkham TC, 2002, BRIT J PHARMACOL, V136, P550, DOI 10.1038/sj.bjp.0704767
   Lemieux I, 2000, CIRCULATION, V102, P179, DOI 10.1161/01.CIR.102.2.179
   Matias I, 2006, J CLIN ENDOCR METAB, V91, P3171, DOI 10.1210/jc.2005-2679
   Monteleone P, 2005, NEUROPSYCHOPHARMACOL, V30, P1216, DOI 10.1038/sj.npp.1300695
   Osei-Hyiaman D, 2005, J CLIN INVEST, V115, P1298, DOI 10.1172/JCI200523057
   Pagotto U, 2006, ENDOCR REV, V27, P73, DOI 10.1210/er.2005-0009
   Pi-Sunyer F, 2006, JAMA-J AM MED ASSOC, V295, P761, DOI 10.1001/jama.295.7.761
   Pi-Sunyer FX, 1998, OBES RES, V6, p51S
   PISUNYER FX, 2006, J AM COLL CARDIOL  S, V47, pA362
   Posner K, 2007, AM J PSYCHIAT, V164, P1035, DOI 10.1176/appi.ajp.164.7.1035
   POULIOT MC, 1992, DIABETES, V41, P826, DOI 10.2337/diabetes.41.7.826
   SCHEEN A, 2006, DIABETOLOGIA S1, V49, P1
   Scheen AJ, 2006, LANCET, V368, P1660, DOI 10.1016/S0140-6736(06)69571-8
   Sipe JC, 2005, INT J OBESITY, V29, P755, DOI 10.1038/sj.ijo.0802954
   Van Gaal L, 2006, J HYPERTENS, V24, pS80
   Van Gaal LF, 2005, LANCET, V365, P1389, DOI 10.1016/S0140-6736(05)66374-X
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 38
TC 172
Z9 188
U1 0
U2 9
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD FEB
PY 2008
VL 31
SU 2
BP S229
EP S240
DI 10.2337/dc08-s258
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism
GA 426IM
UT WOS:000264701200023
PM 18227491
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Li, XN
   Song, J
   Zhang, L
   LeMaire, SA
   Hou, XY
   Zhang, C
   Coselli, JS
   Chen, L
   Wang, XL
   Zhang, Y
   Shen, YH
AF Li, Xiao-Nan
   Song, Jun
   Zhang, Lin
   LeMaire, Scott A.
   Hou, Xiaoyang
   Zhang, Cheng
   Coselli, Joseph S.
   Chen, Li
   Wang, Xing Li
   Zhang, Yun
   Shen, Ying H.
TI Activation of the AMPK-FOXO3 Pathway Reduces Fatty Acid-Induced Increase
   in Intracellular Reactive Oxygen Species by Upregulating Thioredoxin
SO DIABETES
LA English
DT Article
ID PROTEIN-KINASE; OXIDATIVE-STRESS; ENDOTHELIAL-CELLS; CROSS-TALK; FOXO;
   INHIBITION; ADIPONECTIN; SUPPRESSION; RESISTANCE; EXPRESSION
AB OBJECTIVE-Oxidative stress induced by free fatty acids contributes to the development of cardiovascular diseases in patients with metabolic syndrome. Reducing oxidative stress may attenuate these pathogenic processes. Activation of AMP-activated protein kinase (AMPK) has been reported to reduce intraceRular reactive oxygen species (ROS) levels. The thioredoxin (Trx) system is a major antioxidant system. In this study, we investigated the mechanisms involved in the AMPK-mediated regulation of Trx expression and the reduction of intracellular ROS levels.
   RESEARCH DESIGN AND METHODS-We observed that activation of AMPK by 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) significantly reduced ROS levels induced by palmitic acid in human aortic endothelial cells. Activation of AMPK increased expression of the antioxidant Trx, which mediated the ROS reduction. RT-PCR showed that AMPK regulated Trx at the transcriptional level.
   RESULTS-Forkhead transcription factor 3 (FOXO3) was identified as the target transcription factor involved in the upregulation of Trx expression. FOXO3 bound to the Trx promoter, recruited the histone acetylase p300 to the Trx promoter, and formed a transcription activator complex, which was enhanced by AICAR treatment. AMPK activated FOXO3 by promoting its nuclear translocation. We further showed that AICAR injection increased the expression of Trx and decreased ROS production in the aortic wall of ApoE-/- mice fed a high-fat diet.
   CONCLUSIONS-These results suggest that activation of the AMPK-FOXO3 pathway reduces ROS levels by inducing Trx expression. Thus, the AMPK-FOXO3-Trx axis may be an important defense mechanism against excessive ROS production induced by metabolic stress and could be a therapeutic target in treating cardiovascular diseases in metabolic syndrome. Diabetes 58:2246-2257, 2009
C1 [Li, Xiao-Nan; Song, Jun; Hou, Xiaoyang; Zhang, Cheng; Chen, Li; Zhang, Yun] Shandong Univ, Qilu Hosp, Jinan 250100, Shandong, Peoples R China.
   [Li, Xiao-Nan; Song, Jun; Zhang, Lin; LeMaire, Scott A.; Hou, Xiaoyang; Zhang, Cheng; Coselli, Joseph S.; Wang, Xing Li; Shen, Ying H.] Baylor Coll Med, Div Cardiothorac Surg, Michael E DeBakey Dept Surg, Houston, TX 77030 USA.
   [Li, Xiao-Nan; Song, Jun; Zhang, Lin; LeMaire, Scott A.; Hou, Xiaoyang; Zhang, Cheng; Coselli, Joseph S.; Wang, Xing Li; Shen, Ying H.] St Lukes Episcopal Hosp, Texas Heart Inst, Houston, TX USA.
C3 Shandong University; Baylor College of Medicine; Saint Lukes Episcopal
   Hospital; Texas Heart Institute
RP Zhang, Y (corresponding author), Shandong Univ, Qilu Hosp, Jinan 250100, Shandong, Peoples R China.
EM zhangyun@sdu.edu.cn; hyshen@bcm.edu
RI wang, xingli/MHR-1399-2025; shen, ying/HHS-5635-2022
OI LeMaire, Scott/0000-0002-8736-4266
FU American Heart Association [AHA-TX 0565134Y, AHA-073019ON]; National
   Institutes of Health [R01HL071608]; Natural Science Foundation of China
   [2006CB503803, 2006AA02A406]
FX This study was supported by American Heart Association Grants AHA-TX
   0565134Y (to Y.H.S.) and AHA-073019ON (to Y.H.S.), National Institutes
   of Health Grant R01HL071608 (to X.L.W.), and Natural Science Foundation
   of China Grants 2006CB503803 and 2006AA02A406 (to Y.Z.).
CR Alcendor RR, 2007, CIRC RES, V100, P1512, DOI 10.1161/01.RES.0000267723.65696.4a
   Almeida M, 2007, J BIOL CHEM, V282, P27298, DOI 10.1074/jbc.M702811200
   An ZB, 2007, J BIOL CHEM, V282, P26793, DOI 10.1074/jbc.M703701200
   Arden KC, 2007, CELL, V128, P235, DOI 10.1016/j.cell.2007.01.009
   Berndt C, 2007, AM J PHYSIOL-HEART C, V292, pH1227, DOI 10.1152/ajpheart.01162.2006
   Blättler SM, 2007, P NATL ACAD SCI USA, V104, P1045, DOI 10.1073/pnas.0610216104
   Brunet A, 2004, SCIENCE, V303, P2011, DOI 10.1126/science.1094637
   Ceolotto G, 2007, ARTERIOSCL THROM VAS, V27, P2627, DOI 10.1161/ATVBAHA.107.155762
   Civitarese AE, 2006, CELL METAB, V4, P75, DOI 10.1016/j.cmet.2006.05.002
   Depre C, 2006, CIRC RES, V98, P280, DOI 10.1161/01.RES.0000201284.45482.e8
   Gaskin FS, 2007, AM J PHYSIOL-HEART C, V292, pH326, DOI 10.1152/ajpheart.00744.2006
   Greer EL, 2007, J BIOL CHEM, V282, P30107, DOI 10.1074/jbc.M705325200
   Greer EL, 2007, CURR BIOL, V17, P1646, DOI 10.1016/j.cub.2007.08.047
   Guo DL, 2007, CIRC RES, V100, P564, DOI 10.1161/01.RES.0000259561.23876.c5
   Hattangadi SM, 2007, J CLIN INVEST, V117, P2075, DOI 10.1172/JCI32559
   Ido Y, 2002, DIABETES, V51, P159, DOI 10.2337/diabetes.51.1.159
   Kops GJPL, 2002, NATURE, V419, P316, DOI 10.1038/nature01036
   Koshkin V, 2003, J BIOL CHEM, V278, P19709, DOI 10.1074/jbc.M209709200
   Kukidome D, 2006, DIABETES, V55, P120, DOI 10.2337/diabetes.55.1.120
   Lehtinen MK, 2006, CELL, V125, P987, DOI 10.1016/j.cell.2006.03.046
   Madamanchi NR, 2007, CIRC RES, V100, P460, DOI 10.1161/01.RES.0000258450.44413.96
   Marinkovic D, 2007, J CLIN INVEST, V117, P2133, DOI 10.1172/JCI31807
   Nagata D, 2003, J BIOL CHEM, V278, P31000, DOI 10.1074/jbc.M300643200
   Nakamura T, 2008, MOL CELL ENDOCRINOL, V281, P47, DOI 10.1016/j.mce.2007.10.007
   Okuda M, 2001, ARTERIOSCL THROM VAS, V21, P1483, DOI 10.1161/hq0901.095550
   Ouedraogo R, 2006, DIABETES, V55, P1840, DOI 10.2337/db05-1174
   Owusu-Ansah E, 2008, NAT GENET, V40, P356, DOI 10.1038/ng.2007.50
   Saitoh M, 1998, EMBO J, V17, P2596, DOI 10.1093/emboj/17.9.2596
   Schulze PC, 2004, J BIOL CHEM, V279, P30369, DOI 10.1074/jbc.M400549200
   Shen YH, 2006, J BIOL CHEM, V281, P7727, DOI 10.1074/jbc.M511105200
   Shen YH, 2003, J BIOL CHEM, V278, P26715, DOI 10.1074/jbc.M303264200
   Shioji K, 2002, CIRCULATION, V106, P1403, DOI 10.1161/01.CIR.0000027817.55925.B4
   Tao L, 2004, P NATL ACAD SCI USA, V101, P11471, DOI 10.1073/pnas.0402941101
   Tothova Z, 2007, CELL, V128, P325, DOI 10.1016/j.cell.2007.01.003
   Tripathy D, 2003, DIABETES, V52, P2882, DOI 10.2337/diabetes.52.12.2882
   Tsai KL, 2007, NUCLEIC ACIDS RES, V35, P6984, DOI 10.1093/nar/gkm703
   Turoczi T, 2003, J MOL CELL CARDIOL, V35, P695, DOI 10.1016/S0022-2828(03)00117-2
   van der Horst A, 2006, NAT CELL BIOL, V8, P1064, DOI 10.1038/ncb1469
   Wang XL, 2006, DIABETES, V55, P2301, DOI 10.2337/db05-1574
   Wyne KL, 2003, AM J MED, V115, P29, DOI 10.1016/j.amjmed.2003.09.004
   Yamamoto M, 2003, J CLIN INVEST, V112, P1395, DOI 10.1172/JCI200317700
   Yamawaki H, 2003, CIRC RES, V93, P1029, DOI 10.1161/01.RES.0000102869.39150.23
   Zhang HF, 2007, AM J PATHOL, V170, P1108, DOI 10.2353/ajpath.2007.060960
   Zhang M, 2008, CIRC RES, V102, P328, DOI 10.1161/CIRCRESAHA.107.163253
   Zheng X, 2007, P NATL ACAD SCI USA, V104, P15899, DOI 10.1073/pnas.0701599104
   Zou MH, 2002, J BIOL CHEM, V277, P32552, DOI 10.1074/jbc.M204512200
NR 46
TC 203
Z9 234
U1 2
U2 34
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD OCT
PY 2009
VL 58
IS 10
BP 2246
EP 2257
DI 10.2337/db08-1512
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 506LL
UT WOS:000270776200012
PM 19592618
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Dimova, EY
   Samoylenko, A
   Kietzmann, T
AF Dimova, EY
   Samoylenko, A
   Kietzmann, T
TI Oxidative stress and hypoxia: Implications for plasminogen activator
   inhibitor-1 expression
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
ID NF-KAPPA-B; SMOOTH-MUSCLE-CELLS; INDUCIBLE FACTOR-I;
   NECROSIS-FACTOR-ALPHA; SIGNAL-REGULATED KINASE; VASCULAR
   ENDOTHELIAL-CELLS; TUMOR-SUPPRESSOR PROTEIN; LDL-INDUCED GENERATION;
   DNA-BINDING ACTIVITY; GROWTH-FACTOR-BETA
AB Plasminogen activator inhibitor-1 (PAI-1) is the major physiological inhibitor of urokinase-type and tissue-type plasminogen activators. It has gained special interest among clinicians because a number of pathological conditions, such as myocardial infarction, atherosclerosis, thrombosis, several types of cancer, and the metabolic syndrome, as well as type 2 diabetes mellitus, are associated with increased PAI-1 levels. Interestingly, a number of these diseases are also accompanied by oxidative stress and the enhanced production of reactive oxygen species or tissue hypoxia. This article tries to summarize some aspects leading to enhanced PAI-1 production under oxidative stress or hypoxia.
C1 Inst Biochem & Mol Zellbiol, D-37073 Gottingen, Germany.
RP Inst Biochem & Mol Zellbiol, Humboldtallee 23, D-37073 Gottingen, Germany.
EM tkietzm@gwdg.de
RI Dimova, Emiliya/D-1110-2010; Samoylenko, Anatoliy/AAN-1992-2021
OI Dimova, Elitsa/0000-0003-2745-8145; Kietzmann,
   Thomas/0000-0003-0242-8636; Samoylenko, Anatoliy/0000-0002-0240-897X
CR ABATE C, 1990, SCIENCE, V249, P1157, DOI 10.1126/science.2118682
   Abe J, 1996, CIRCULATION, V94, P1627
   Abe J, 1997, J BIOL CHEM, V272, P20389, DOI 10.1074/jbc.272.33.20389
   ABE MK, 1994, AM J RESP CELL MOL, V11, P577, DOI 10.1165/ajrcmb.11.5.7946386
   Alessi DR, 1996, EMBO J, V15, P6541, DOI 10.1002/j.1460-2075.1996.tb01045.x
   Allen RG, 2000, FREE RADICAL BIO MED, V28, P463, DOI 10.1016/S0891-5849(99)00242-7
   AMMENDOLA R, 1994, EUR J BIOCHEM, V225, P483, DOI 10.1111/j.1432-1033.1994.t01-1-00483.x
   Andrew AS, 2001, AM J PHYSIOL-LUNG C, V281, pL607, DOI 10.1152/ajplung.2001.281.3.L607
   Andrew AS, 2001, AM J PHYSIOL-LUNG C, V281, pL616, DOI 10.1152/ajplung.2001.281.3.L616
   Arts J, 1996, EUR J BIOCHEM, V241, P393, DOI 10.1111/j.1432-1033.1996.00393.x
   Bae YS, 1997, J BIOL CHEM, V272, P217, DOI 10.1074/jbc.272.1.217
   Banfi C, 2003, THROMB HAEMOSTASIS, V89, P544
   Banfi C, 2001, DIABETES, V50, P1522, DOI 10.2337/diabetes.50.7.1522
   Bhat NR, 1999, J NEUROCHEM, V72, P112, DOI 10.1046/j.1471-4159.1999.0720112.x
   Binder BR, 2002, NEWS PHYSIOL SCI, V17, P56, DOI 10.1152/nips.01369.2001
   Bowie AG, 2000, J IMMUNOL, V165, P7180, DOI 10.4049/jimmunol.165.12.7180
   Bruick RK, 2001, SCIENCE, V294, P1337, DOI 10.1126/science.1066373
   Cadenas E, 1985, Adv Enzyme Regul, V23, P217, DOI 10.1016/0065-2571(85)90049-4
   Cai H, 2000, CIRC RES, V87, P840, DOI 10.1161/01.RES.87.10.840
   Carrero P, 2000, MOL CELL BIOL, V20, P402, DOI 10.1128/MCB.20.1.402-415.2000
   CERIELLO A, 1995, BLOOD COAGUL FIBRIN, V6, P133, DOI 10.1097/00001721-199504000-00008
   CERIELLO A, 1991, DIABETIC MED, V8, P540, DOI 10.1111/j.1464-5491.1991.tb01647.x
   Chen XL, 2004, AM J PHYSIOL-HEART C, V286, pH1001, DOI 10.1152/ajpheart.00716.2003
   Chen YQ, 1998, J BIOL CHEM, V273, P8225, DOI 10.1074/jbc.273.14.8225
   Chen YQ, 2001, THROMB HAEMOSTASIS, V86, P1563, DOI 10.1055/s-0037-1616763
   Cheng JJ, 1996, BIOCHEM BIOPH RES CO, V225, P100, DOI 10.1006/bbrc.1996.1136
   Corda S, 2001, AM J RESP CELL MOL, V24, P762, DOI 10.1165/ajrcmb.24.6.4228
   Crossthwaite AJ, 2002, J NEUROCHEM, V80, P24, DOI 10.1046/j.0022-3042.2001.00637.x
   Dandona P, 1996, LANCET, V347, P444, DOI 10.1016/S0140-6736(96)90013-6
   DAWSON SJ, 1993, J BIOL CHEM, V268, P10739
   DESCHEEMAEKER KA, 1992, J BIOL CHEM, V267, P15086
   Downward J, 1998, CURR OPIN CELL BIOL, V10, P262, DOI 10.1016/S0955-0674(98)80149-X
   Du KY, 1998, J BIOL CHEM, V273, P32377, DOI 10.1074/jbc.273.49.32377
   Du XL, 2000, P NATL ACAD SCI USA, V97, P12222, DOI 10.1073/pnas.97.22.12222
   Eberhardt W, 2002, KIDNEY INT, V61, P20, DOI 10.1046/j.1523-1755.2002.00087.x
   Ehleben W, 1998, RESP PHYSIOL, V114, P25, DOI 10.1016/S0034-5687(98)00078-4
   Ema M, 1999, EMBO J, V18, P1905, DOI 10.1093/emboj/18.7.1905
   FANDREY J, 1994, BIOCHEM J, V303, P507, DOI 10.1042/bj3030507
   Feldser D, 1999, CANCER RES, V59, P3915
   Fink T, 2002, BLOOD, V99, P2077, DOI 10.1182/blood.V99.6.2077
   Fink T, 2001, CELL PHYSIOL BIOCHEM, V11, P105, DOI 10.1159/000047798
   Forman HJ, 2002, MOL CELL BIOCHEM, V234, P49, DOI 10.1023/A:1015913229650
   FREEMAN BA, 1982, LAB INVEST, V47, P412
   GERTLER J, 1993, J VASC SURG, V18, P936
   Ghosh S, 2002, CELL, V109, pS81, DOI 10.1016/S0092-8674(02)00703-1
   Görlach A, 2003, THROMB HAEMOSTASIS, V89, P926
   Görlach A, 2001, CIRC RES, V89, P47, DOI 10.1161/hh1301.092678
   GOTTLIEB TM, 1993, CELL, V72, P131, DOI 10.1016/0092-8674(93)90057-W
   Haddad JJE, 2000, J BIOL CHEM, V275, P21130, DOI 10.1074/jbc.M000737200
   Hamaguchi E, 2003, J PHARMACOL EXP THER, V307, P987, DOI 10.1124/jpet.103.054346
   HAN J, 1994, SCIENCE, V265, P808, DOI 10.1126/science.7914033
   Hayakawa M, 2003, EMBO J, V22, P3356, DOI 10.1093/emboj/cdg332
   Huang LE, 1996, J BIOL CHEM, V271, P32253, DOI 10.1074/jbc.271.50.32253
   Imbert V, 1996, CELL, V86, P787, DOI 10.1016/S0092-8674(00)80153-1
   JACKSON SP, 1988, CELL, V55, P125, DOI 10.1016/0092-8674(88)90015-3
   Jiang Z, 2003, BIOCHEM BIOPH RES CO, V309, P961, DOI 10.1016/j.bbrc.2003.08.102
   JUHANVAGUE I, 1991, DIABETOLOGIA, V34, P457, DOI 10.1007/BF00403280
   Karin M, 2000, ANNU REV IMMUNOL, V18, P621, DOI 10.1146/annurev.immunol.18.1.621
   Kasza A, 2002, J NEUROCHEM, V83, P696, DOI 10.1046/j.1471-4159.2002.01163.x
   Kietzmann T, 1999, BLOOD, V94, P4177, DOI 10.1182/blood.V94.12.4177.424k14_4177_4185
   Kietzmann T, 2003, THROMB HAEMOSTASIS, V89, P666
   Kietzmann T, 2003, BLOOD, V101, P907, DOI 10.1182/blood-2002-06-1693
   Kitaura J, 2000, J EXP MED, V192, P729, DOI 10.1084/jem.192.5.729
   KNOEPFEL L, 1994, BIOCHEM BIOPH RES CO, V201, P871, DOI 10.1006/bbrc.1994.1782
   KOBAYASHI K, 1995, ENDOCR J, V42, P461, DOI 10.1507/endocrj.42.461
   Kohler HP, 2000, NEW ENGL J MED, V342, P1792, DOI 10.1056/NEJM200006153422406
   Kops GJPL, 1999, NATURE, V398, P630, DOI 10.1038/19328
   KRUITHOF EKO, 1986, J BIOL CHEM, V261, P1207
   Kyriakis JM, 2001, PHYSIOL REV, V81, P807, DOI 10.1152/physrev.2001.81.2.807
   Lando D, 2002, GENE DEV, V16, P1466, DOI 10.1101/gad.991402
   Lee E, 2002, MOL CELLS, V14, P9
   Li NX, 1998, P NATL ACAD SCI USA, V95, P13012, DOI 10.1073/pnas.95.22.13012
   Li NX, 1999, FASEB J, V13, P1137, DOI 10.1096/fasebj.13.10.1137
   LO YYC, 1995, J BIOL CHEM, V270, P11727, DOI 10.1074/jbc.270.20.11727
   Maxwell PH, 1999, NATURE, V399, P271, DOI 10.1038/20459
   Mazure NM, 1997, BLOOD, V90, P3322, DOI 10.1182/blood.V90.9.3322
   MEYER M, 1993, EMBO J, V12, P2005, DOI 10.1002/j.1460-2075.1993.tb05850.x
   MIMURO J, 1989, J BIOL CHEM, V264, P936
   Motojima M, 2000, BIOCHEM J, V349, P435, DOI 10.1042/0264-6021:3490435
   Motojima M, 2003, KIDNEY INT, V63, P1671, DOI 10.1046/j.1523-1755.2003.00906.x
   Mucsi I, 1996, J AM SOC NEPHROL, V7, pA2572
   Nishikawa T, 2000, NATURE, V404, P787, DOI 10.1038/35008121
   NOSE K, 1991, EUR J BIOCHEM, V201, P99, DOI 10.1111/j.1432-1033.1991.tb16261.x
   Okada H, 1998, CIRCULATION, V97, P2175, DOI 10.1161/01.CIR.97.21.2175
   Oller AR, 1997, TOXICOL APPL PHARM, V143, P152, DOI 10.1006/taap.1996.8075
   PESSARA U, 1990, MOL CELL BIOL, V10, P4146, DOI 10.1128/MCB.10.8.4146
   Pinsky DJ, 1998, J CLIN INVEST, V102, P919, DOI 10.1172/JCI307
   RAINGEAUD J, 1995, J BIOL CHEM, V270, P7420, DOI 10.1074/jbc.270.13.7420
   Rajagopalan S, 1996, J CLIN INVEST, V97, P1916, DOI 10.1172/JCI118623
   Rao GN, 1997, CELL SIGNAL, V9, P181, DOI 10.1016/S0898-6568(96)00139-8
   Ren S, 2000, ARTERIOSCL THROM VAS, V20, P1688, DOI 10.1161/01.ATV.20.6.1688
   Richard DE, 2000, J BIOL CHEM, V275, P26765
   Richard DE, 1999, J BIOL CHEM, V274, P32631, DOI 10.1074/jbc.274.46.32631
   Roth U, 2004, J BIOL CHEM, V279, P2623, DOI 10.1074/jbc.M308391200
   Ryu H, 2003, J NEUROSCI, V23, P3597
   Saitoh M, 1998, EMBO J, V17, P2596, DOI 10.1093/emboj/17.9.2596
   Sakamoto T, 1999, AM J PHYSIOL-CELL PH, V276, pC1391, DOI 10.1152/ajpcell.1999.276.6.C1391
   Samoylenko A, 2001, BLOOD, V97, P2657, DOI 10.1182/blood.V97.9.2657
   Sang NL, 2003, J BIOL CHEM, V278, P14013, DOI 10.1074/jbc.M209702200
   Santini SA, 1997, DIABETES, V46, P1853, DOI 10.2337/diabetes.46.11.1853
   SCHENK H, 1994, P NATL ACAD SCI USA, V91, P1672, DOI 10.1073/pnas.91.5.1672
   SCHLEEF RR, 1988, J BIOL CHEM, V263, P5797
   SCHMIDT KN, 1995, J BIOL CHEM, V270, P27136, DOI 10.1074/jbc.270.45.27136
   SCHRECK R, 1992, FREE RADICAL RES COM, V17, P221, DOI 10.3109/10715769209079515
   SCHRECK R, 1991, EMBO J, V10, P2247, DOI 10.1002/j.1460-2075.1991.tb07761.x
   Schreck R, 1991, Trends Cell Biol, V1, P39, DOI 10.1016/0962-8924(91)90072-H
   SCHRECK R, 1992, J EXP MED, V175, P1181, DOI 10.1084/jem.175.5.1181
   SHATOS MA, 1992, J BIOL CHEM, V267, P597
   SHATOS MA, 1990, J BIOL CHEM, V265, P20443
   Shaulian E, 2001, ONCOGENE, V20, P2390, DOI 10.1038/sj.onc.1204383
   Sodhi A, 2001, BIOCHEM BIOPH RES CO, V287, P292, DOI 10.1006/bbrc.2001.5532
   STARKEBAUM G, 1986, J CLIN INVEST, V77, P1370, DOI 10.1172/JCI112442
   STEIN B, 1989, MOL CELL BIOL, V9, P5169, DOI 10.1128/MCB.9.11.5169
   STEVENSON MA, 1994, CANCER RES, V54, P12
   Sundaresan M, 1996, BIOCHEM J, V318, P379, DOI 10.1042/bj3180379
   Swiatkowska M, 2002, CELL MOL BIOL LETT, V7, P1065
   SWICK AG, 1989, NUCLEIC ACIDS RES, V17, P9291, DOI 10.1093/nar/17.22.9291
   Takahashi H, 2000, NEUROREPORT, V11, P1111, DOI 10.1097/00001756-200004070-00040
   Tanimoto K, 2000, EMBO J, V19, P4298, DOI 10.1093/emboj/19.16.4298
   Thannickal VJ, 2000, AM J PHYSIOL-LUNG C, V279, pL1005
   Tobiume K, 2002, J CELL PHYSIOL, V191, P95, DOI 10.1002/jcp.10080
   Uchiyama T, 2000, DIABETES, V49, pA213
   Wang XT, 1998, BIOCHEM J, V333, P291, DOI 10.1042/bj3330291
   Wenger RH, 2002, FASEB J, V16, DOI 10.1096/fj.01-0944rev
   Wiesener MS, 1998, BLOOD, V92, P2260, DOI 10.1182/blood.V92.7.2260.2260_2260_2268
   Wu XS, 1996, MOL CELL BIOL, V16, P1035
   XANTHOUDAKIS S, 1992, EMBO J, V11, P653, DOI 10.1002/j.1460-2075.1992.tb05097.x
   Xu D, 2000, FEBS LETT, V470, P20, DOI 10.1016/S0014-5793(00)01278-3
   Yamamoto K, 1998, INT J HEMATOL, V68, P371
   Zelzer E, 1998, EMBO J, V17, P5085, DOI 10.1093/emboj/17.17.5085
   Zhang JH, 1998, AM J RESP CELL MOL, V19, P324, DOI 10.1165/ajrcmb.19.2.3209
   Zhang JY, 1998, ARTERIOSCL THROM VAS, V18, P1140, DOI 10.1161/01.ATV.18.7.1140
   Zhao WL, 2001, CANCER RES, V61, P5537
NR 133
TC 44
Z9 45
U1 1
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD AUG
PY 2004
VL 6
IS 4
BP 777
EP 791
DI 10.1089/1523086041361596
PG 15
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 843SI
UT WOS:000223106400012
PM 15242559
DA 2025-06-11
ER

PT J
AU Girona, J
   Rodríguez-Borjabad, C
   Ibarretxe, D
   Vallvé, JC
   Ferré, R
   Heras, M
   Rodríguez-Calvo, R
   Guaita-Esteruelas, S
   Martínez-Micaelo, N
   Plana, N
   Masana, L
AF Girona, Josefa
   Rodriguez-Borjabad, Celia
   Ibarretxe, Daiana
   Vallve, Joan-Carles
   Ferre, Raimon
   Heras, Mercedes
   Rodriguez-Calvo, Ricardo
   Guaita-Esteruelas, Sandra
   Martinez-Micaelo, Neus
   Plana, Nuria
   Masana, Lluis
TI The Circulating GRP78/BiP Is a Marker of Metabolic Diseases and
   Atherosclerosis: Bringing Endoplasmic Reticulum Stress into the Clinical
   Scenario
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE GRP78/BiP; endoplasmic reticulum stress; atherosclerosis; carotid
   intima-media thickness; obesity; type 2 diabetes; metabolic syndrome;
   cardiovascular risk; fenofibrate/niacin treatment
ID ER STRESS; ADIPOSE-TISSUE; INSULIN; OBESE; CHOLESTEROL; FENOFIBRATE;
   HOMEOSTASIS; RESISTANCE; INDUCTION; MECHANISM
AB Background: Glucose-regulated protein 78/Binding immunoglobulin protein (GRP78/BiP) is a protein associated with endoplasmic reticulum stress and is upregulated by metabolic alterations at the tissue-level, such as hypoxia or glucose deprivation, and it is hyper-expressed in fat tissue of obese individuals. Objective: To investigate the role of the GRP78/BiP level as a metabolic and vascular disease biomarker in patients with type 2 diabetes (DM), obesity and metabolic syndrome (MS). Methods: Four hundred and five patients were recruited, of whom 52.5% were obese, 72.8% had DM, and 78.6% had MS. The intimae media thickness (cIMT) was assessed by ultrasonography. The plasma GRP78/BiP concentration was determined, and its association with metabolic and vascular parameters was assessed. Circulating GRP78/BiP was also prospectively measured in 30 DM patients before and after fenofibrate/niacin treatment and 30 healthy controls. Results: In the cross-sectional study, the GRP78/BiP level was significantly higher in the patients with obesity, DM, and MS. Age-, gender- and BMI-adjusted GRP78/BiP was directly associated with LDL-cholesterol, non-HDL-cholesterol, triglycerides, apoB, and cIMT. GRP78/BiP was positively associated to carotid plaque presence in the adjusted model, irrespective of obesity, DM and MS. In the prospective study, nicotinic acid treatment produced a significant reduction in the GRP78/BiP levels that was not observed with fenofibrate. Conclusions: GRP78/BiP plasma concentrations are increased in patients with both metabolic derangements and subclinical atherosclerosis. GRP78/BiP could be a useful marker of metabolic and cardiovascular risk.
C1 [Girona, Josefa; Rodriguez-Borjabad, Celia; Ibarretxe, Daiana; Vallve, Joan-Carles; Ferre, Raimon; Heras, Mercedes; Rodriguez-Calvo, Ricardo; Guaita-Esteruelas, Sandra; Martinez-Micaelo, Neus; Plana, Nuria; Masana, Lluis] Univ Rovira & Virgili, St Joan Univ Hosp, Vasc Med & Metab Unit, IISPV,Res Unit Lipids & Atherosclerosis, Reus 43201, Spain.
   [Girona, Josefa; Rodriguez-Borjabad, Celia; Ibarretxe, Daiana; Vallve, Joan-Carles; Ferre, Raimon; Heras, Mercedes; Rodriguez-Calvo, Ricardo; Martinez-Micaelo, Neus; Plana, Nuria; Masana, Lluis] Spanish Biomed Res Ctr Diabet & Associated Metab, Madrid 28029, Spain.
C3 Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV)
RP Masana, L (corresponding author), Univ Rovira & Virgili, St Joan Univ Hosp, Vasc Med & Metab Unit, IISPV,Res Unit Lipids & Atherosclerosis, Reus 43201, Spain.; Masana, L (corresponding author), Spanish Biomed Res Ctr Diabet & Associated Metab, Madrid 28029, Spain.
EM josefa.girona@urv.cat; celia.nutricio@gmail.com;
   daiana.ibarretxe@urv.cat; jc.vallve@urv.cat; rferre@grupsagessa.cat;
   mercedes.heras@urv.cat; ricardo.rodriguez@ciberdem.com;
   sandra.guaita@urv.cat; neus.martinez@urv.cat; nplana@grupsagessa.cat;
   luis.masana@urv.cat
RI Rodriguez-Calvo, Ricardo/AAB-4054-2019; Vallvé, Joan-Carles/T-6742-2019;
   MASANA, LUIS/M-7002-2019; Girona, Josefa/U-3489-2018
OI Girona, Josefa/0000-0002-6267-8779; Vallve,
   Joan-Carles/0000-0001-8711-9618; Rodriguez-Borjabad,
   Celia/0000-0001-8160-3716; Plana, Nuria/0000-0002-4231-7618;
   Martinez-Micaelo, Neus/0000-0001-6101-2847; Masana,
   Luis/0000-0002-0789-4954; Ibarretxe, Daiana/0000-0002-5442-1930
FU Instituto de Salud Carlos III (ISCIII), Madrid, Spain [PI15/00627,
   PI18/00515]; Spanish Biomedical Research Centre in Diabetes and
   Associated Metabolic Disorders (CIBERDEM) - European Regional
   Development Fund (ERDF)
FX This study was funded by grants from Instituto de Salud Carlos III
   (ISCIII), Madrid, Spain (PI15/00627; PI18/00515). This work was jointly
   supported by national funding from the Spanish Biomedical Research
   Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM). This
   work was co-funded by the European Regional Development Fund (ERDF).
CR Aksoy MO, 2017, RESP RES, V18, DOI 10.1186/s12931-017-0561-6
   Ali AH, 2015, DIABETES, V64, P2828, DOI 10.2337/db14-1409
   Back SH, 2012, ANNU REV BIOCHEM, V81, P767, DOI 10.1146/annurev-biochem-072909-095555
   Balasus D, 2016, ONCOTARGET, V7, P86791, DOI 10.18632/oncotarget.13558
   Boden G, 2008, DIABETES, V57, P2438, DOI 10.2337/db08-0604
   Cominacini L, 2015, CURR MED CHEM, V22, P1565, DOI 10.2174/0929867322666150311150829
   Fang Lingling, 2015, J Proteomics Bioinform, V8, P133
   Feaver RE, 2008, ARTERIOSCL THROM VAS, V28, P1534, DOI 10.1161/ATVBAHA.108.167999
   Forcheron F, 2002, DIABETES, V51, P3486, DOI 10.2337/diabetes.51.12.3486
   Gregor MF, 2009, DIABETES, V58, P693, DOI 10.2337/db08-1220
   Han J, 2016, J LIPID RES, V57, P1329, DOI 10.1194/jlr.R067595
   Khadir A, 2016, METABOLISM, V65, P1409, DOI 10.1016/j.metabol.2016.06.004
   Levy JC, 1998, DIABETES CARE, V21, P2191, DOI 10.2337/diacare.21.12.2191
   Li ZW, 2016, SCI REP-UK, V6, DOI 10.1038/srep30406
   Ma X, 2015, DIS MARKERS, V2015, P1, DOI 10.1155/2015/814670
   Masana L, 2015, ATHEROSCLEROSIS, V238, P213, DOI 10.1016/j.atherosclerosis.2014.12.006
   Mazaki Y, 2019, FEBS LETT, V593, P644, DOI 10.1002/1873-3468.13347
   McGrath KCY, 2012, ENDOCRINOLOGY, V153, P2949, DOI 10.1210/en.2012-1478
   Myoishi M, 2007, CIRCULATION, V116, P1226, DOI 10.1161/CIRCULATIONAHA.106.682054
   Nakatani Y, 2005, J BIOL CHEM, V280, P847, DOI 10.1074/jbc.M411860200
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Pobre KFR, 2019, J BIOL CHEM, V294, P2098, DOI 10.1074/jbc.REV118.002804
   Rui L, 2017, ONCOTARGET, V8, P19354, DOI 10.18632/oncotarget.15223
   Sharma NK, 2008, J CLIN ENDOCR METAB, V93, P4532, DOI 10.1210/jc.2008-1001
   SHIU RPC, 1977, P NATL ACAD SCI USA, V74, P3840, DOI 10.1073/pnas.74.9.3840
   Sozen E, 2017, REDOX BIOL, V12, P456, DOI 10.1016/j.redox.2017.02.025
   Todd DJ, 2008, NAT REV IMMUNOL, V8, P663, DOI 10.1038/nri2359
   Touboul PJ, 2012, CEREBROVASC DIS, V34, P290, DOI 10.1159/000343145
   Tsai YL, 2015, J BIOL CHEM, V290, P8049, DOI 10.1074/jbc.M114.618736
   Yang D, 2014, FEBS LETT, V588, P4448, DOI 10.1016/j.febslet.2014.09.046
   Ye RS, 2010, DIABETES, V59, P6, DOI 10.2337/db09-0755
   Zhou J, 2005, CIRCULATION, V111, P1814, DOI 10.1161/01.CIR.0000160864.31351.C1
NR 33
TC 52
Z9 53
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD NOV
PY 2019
VL 8
IS 11
AR 1793
DI 10.3390/jcm8111793
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA JV3VR
UT WOS:000502294400036
PM 31717752
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mihai, A
   Lixandru, D
   Alexandru, P
   Stoian, I
   Carniciu, S
   Mitu, M
   Guja, C
   Ionescu-Tirgoviste, C
AF Mihai, Andrada
   Lixandru, Daniela
   Alexandru, Petruta
   Stoian, Irina
   Carniciu, Simona
   Mitu, Manuela
   Guja, Cristian
   Ionescu-Tirgoviste, Constantin
TI Negative association between paraoxonase 2, anthropometric markers and
   metabolic syndrome
SO OPEN LIFE SCIENCES
LA English
DT Article
DE type 2 diabetes; metabolic syndrome; paraoxonase 2; total oxidant and
   antioxidant status
ID LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; SERUM PARAOXONASE; PROTEIN;
   PLASMA; COMPLICATIONS; CHOLESTEROL; GENERATION; GLUCOSE; PON3
AB Background Metabolic syndrome (MS) has a great impact on cardiovascular mortality and morbidity. Our aim was to investigate the association of MS with some oxidant and antioxidant markers, including pro- and antioxidant status of peripheral blood mononuclear cells (PBMC) in newly diagnosed type 2 diabetic mellitus patients (ND-T2D).
   Methods 219 ND-T2D and 88 healthy subjects were divided in two groups according to the absence or presence of MS. Anthropometric measurements, routine blood tests, total oxidant status (TOS), total antioxidant status (TAS) and ELISA measurements were included. The PBMC capacity to release free radicals and to neutralize them was also determined by measuring the respiratory burst (RB) together with the lactonase activity of the intracellular antioxidant enzyme paraoxonase 2 (PON2).
   Results Comparing ND-T2D MS+ with those MS-the RB of the PBMC was significantly higher (p<0.05) while lactonase PON2 enzymatic activity was decreased (p < 0.001). A negative correlation of RB was found with TAS (r = -0.416, p < 0.05). PON2 was also negatively correlated with glycaemia (r = -0.275, p < 0.001), HbA(1c) (r = -0.308, p < 0.001), weight (r = -0.183; p < 0.05), waist circumference (r = -0.353, p < 0.001) and body mass index (r = -0.290, p < 0.001).
   Conclusion PON2 lactonase activity is negatively associated with anthropometric markers in ND-T2D with MS.
C1 [Lixandru, Daniela; Alexandru, Petruta] Romanian Acad, Dept Mol Cell Biol, Inst Biochem, Bucharest, Romania.
   [Mihai, Andrada; Carniciu, Simona; Mitu, Manuela; Guja, Cristian; Ionescu-Tirgoviste, Constantin] NIDNMD Prof NC Paulescu, Bucharest, Romania.
C3 Romanian Academy; Nicolae Simionescu Institute of Cellular Biology &
   Pathology; Institute of Biochemistry, Bucharest
RP Lixandru, D (corresponding author), Univ Med & Pharm Carol Davila, Bucharest, Romania.
EM daniela.lixandru@umf.ro
RI Lixandru, Daniela/U-4330-2017; Guja, Cristian/K-2334-2019; Stoian,
   Irina/H-5789-2011; Mihai, Doina Andrada/JZT-5214-2024; Petruta-ramona,
   Alexandru/JRW-0573-2023
OI Stoian, Irina/0000-0002-0271-9946; /0009-0008-4925-2221
FU Romanian National Authority for Scientific Research, CNCS-UEFISCDI
   [PN-II-ID-PCE-2011-3-0429]; European Social Fund [POSDRU/89/1.5/S/60746,
   POSDRU/107/1.5/S/82514]
FX This work was supported by a grant from the Romanian National Authority
   for Scientific Research, CNCS-UEFISCDI, project number
   PN-II-ID-PCE-2011-3-0429. Dr. Daniela Lixandru was also supported by the
   postdoctoral program POSDRU/89/1.5/S/60746 and Petruta Alexandru by the
   program POSDRU/107/1.5/S/82514 from European Social Fund. We gratefully
   acknowledge Laura Petcu, Ariana Picu and Janeta Tudosoiu from the
   research laboratory of NIDNMD "Prof. N. Paulescu", for excellent
   technical assistance in conducting the clinical study.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   ALLEN RC, 1976, BIOCHEM BIOPH RES CO, V69, P245, DOI 10.1016/S0006-291X(76)80299-9
   Bacanu E., 2012, FARMACIA, V60, P21
   BAYNES JW, 1991, DIABETES, V40, P405, DOI 10.2337/diabetes.40.4.405
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Carr DB, 2004, DIABETES, V53, P2087, DOI 10.2337/diabetes.53.8.2087
   Draganov DI, 2000, J BIOL CHEM, V275, P33435, DOI 10.1074/jbc.M004543200
   Draganov DI, 2005, J LIPID RES, V46, P1239, DOI 10.1194/jlr.M400511-JLR200
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Horke S, 2010, BIOCHEM J, V426, P73, DOI 10.1042/BJ20091414
   Hutcheson R, 2012, EXP DIABETES RES, DOI 10.1155/2012/271028
   King GL, 1996, ENDOCRIN METAB CLIN, V25, P255, DOI 10.1016/S0889-8529(05)70324-8
   KLEIN RL, 1992, DIABETES, V41, P1301, DOI 10.2337/diabetes.41.10.1301
   Le Lay S, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/908539
   Mackness B, 2010, IUBMB LIFE, V62, P480, DOI 10.1002/iub.347
   Marsillach J, 2008, FREE RADICAL BIO MED, V45, P146, DOI 10.1016/j.freeradbiomed.2008.03.023
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mohanty P, 2000, J CLIN ENDOCR METAB, V85, P2970, DOI 10.1210/jc.85.8.2970
   Mohanty P, 2002, AM J CLIN NUTR, V75, P767, DOI 10.1093/ajcn/75.4.767
   Ng CJ, 2001, J BIOL CHEM, V276, P44444, DOI 10.1074/jbc.M105660200
   Reddy ST, 2008, CURR OPIN LIPIDOL, V19, P405, DOI 10.1097/MOL.0b013e328304b64e
   Rösen P, 2001, DIABETES-METAB RES, V17, P189, DOI 10.1002/dmrr.196
   Savu O, 2012, J INT MED RES, V40, P709, DOI 10.1177/147323001204000235
   Shih DM, 1998, NATURE, V394, P284, DOI 10.1038/28406
   Sorenson RC, 1999, ARTERIOSCL THROM VAS, V19, P2214, DOI 10.1161/01.ATV.19.9.2214
   Tabur S, 2010, EUR J ENDOCRINOL, V162, P535, DOI 10.1530/EJE-09-0732
   World Health Organization, 2011, USE GLYCATED HAEMOGL
   World of Health Organization (WHO), 2006, International diabetes federation
NR 30
TC 0
Z9 0
U1 0
U2 4
PU DE GRUYTER POLAND SP ZOO
PI WARSAW
PA BOGUMILA ZUGA 32A STR., 01-811 WARSAW, POLAND
SN 2391-5412
J9 OPEN LIFE SCI
JI Open Life Sci.
PD JAN
PY 2015
VL 10
IS 1
BP 365
EP 371
DI 10.1515/biol-2015-0037
PG 7
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA DF6OR
UT WOS:000371475600010
OA gold
DA 2025-06-11
ER

PT J
AU Zák, A
   Burda, M
   Vecka, M
   Zeman, M
   Tvrzická, E
   Stanková, B
AF Zak, A.
   Burda, M.
   Vecka, M.
   Zeman, M.
   Tvrzicka, E.
   Stankova, B.
TI Fatty Acid Composition Indicates Two Types of Metabolic Syndrome
   Independent of Clinical and Laboratory Parameters
SO PHYSIOLOGICAL RESEARCH
LA English
DT Article
DE Metabolic syndrome; Fatty acids; Delta desaturase activities; Cluster
   analysis
ID ESTIMATED DESATURASE ACTIVITIES; INSULIN-RESISTANCE; PALMITOLEIC ACID;
   PLASMA-GLUCOSE; SERUM-LIPIDS; DIETARY-FAT; RISK; OBESITY; INFLAMMATION;
   POPULATION
AB Dietary composition and metabolism of fatty acids (FA) influence insulin resistance, atherogenic dyslipidemia and other components of the metabolic syndrome (MS). It is known that patients with MS exhibit a heterogeneous phenotype; however, the relationships of individual FA to MS components have not yet been consistently studied. We examined the plasma phosphatidylcholine FA composition of 166 individuals (68F/98M) with MS and of 188 (87F/101M) controls. Cluster analysis of FA divided the groups into two clusters. In cluster 1, there were 65.7 % of MS patients and 37.8 % of controls, cluster 2 contained 34.3 % of patients and 62.2 % of controls (P<0.001). Those with MS within cluster 1 (MS1) differed from individuals with MS in cluster 2 (MS2) by concentrations of glucose (P<0.05), NEFA (P<0.001), HOMA-IR (P<0.05), and levels of conjugated dienes in LDL (P<0.05). The FA composition in MS1 group differed from MS2 by higher contents of palmitoleic (+30 %), gamma-linolenic (+22 %), dihomo-gamma-linolenic (+9 %) acids and by a lower content of linoleic acid(-25 %) (all P<0.01). These FA patterns are supposed to be connected with the progression and/ or impaired biochemical measures of MS (lipolysis, oxidative stress, dysglycidemia, and insulin resistance).
C1 [Zak, A.; Vecka, M.; Zeman, M.; Tvrzicka, E.; Stankova, B.] Charles Univ Prague, Fac Med 1, Dept Med 4, Gen Univ Hosp Prague, U Nemocnice 2, Prague 12808 2, Czech Republic.
   [Burda, M.] Univ Ostrava, Ctr Excellence IT4Innovat, Inst Res & Applicat Fuzzy Modeling, Ostrava, Czech Republic.
C3 Charles University Prague; General University Hospital Prague;
   University of Ostrava
RP Zák, A (corresponding author), Charles Univ Prague, Fac Med 1, Dept Med 4, Gen Univ Hosp Prague, U Nemocnice 2, Prague 12808 2, Czech Republic.
EM azak@vfn.cz
RI Stankova, Barbora/L-7933-2016; Burda, Michal/D-6699-2014; Tvrzicka,
   Eva/Q-6300-2016; Vecka, Marek/A-3560-2008; Zak, Ales/G-8318-2016; Zeman,
   Miroslav/J-5281-2016
OI Burda, Michal/0000-0002-4182-4407; Tvrzicka, Eva/0000-0003-0794-8454;
   Vecka, Marek/0000-0002-3269-1817; Zak, Ales/0000-0002-1698-6068; Zeman,
   Miroslav/0000-0001-5338-603X
FU IGA, Ministry of Health [NT/13199]; Czech Republic [RVO VFN64165/2012,
   PRVOUK P25/LF1/2]; European Regional Development Fund in the project of
   IT4 Innovations Centre of Excellence [CZ. 1.05/1.1.00/02.0070, VP6]
FX This research was supported by the grant NT/13199, IGA, Ministry of
   Health, the Czech Republic, RVO VFN64165/2012, PRVOUK P25/LF1/2, and by
   the European Regional Development Fund in the project of IT4 Innovations
   Centre of Excellence (CZ. 1.05/1.1.00/02.0070, VP6).
CR Aarsland A, 1997, AM J CLIN NUTR, V65, P1774, DOI 10.1093/ajcn/65.6.1774
   Ahotupa M, 1996, CLIN BIOCHEM, V29, P139, DOI 10.1016/0009-9120(95)02043-8
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   [Anonymous], 2014, The R Foundation for Statistical Computing
   ASSMANN G, 2009, CLIN LIPIDOL, P85
   Bruce KD, 2009, POSTGRAD MED J, V85, P614, DOI 10.1136/pgmj.2008.078014
   Carey DGP, 1998, CURR OPIN LIPIDOL, V9, P35, DOI 10.1097/00041433-199802000-00008
   Chien KL, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-33
   Decsi T, 2000, LIPIDS, V35, P1179, DOI 10.1007/s11745-000-0634-7
   Ervin R Bethene, 2009, Natl Health Stat Report, P1
   Hardwick JP, 2013, ADV PHARMACOL, V66, P157, DOI 10.1016/B978-0-12-404717-4.00005-6
   Hodson L, 2008, PROG LIPID RES, V47, P348, DOI 10.1016/j.plipres.2008.03.003
   Kalupahana NS, 2012, MOL ASPECTS MED, V33, P26, DOI 10.1016/j.mam.2011.10.011
   Kawashima A, 2009, J NUTR SCI VITAMINOL, V55, P400, DOI 10.3177/jnsv.55.400
   Klein-Platat C, 2005, AM J CLIN NUTR, V82, P1178, DOI 10.1093/ajcn/82.6.1178
   Laaksonen DE, 2002, DIABETIC MED, V19, P456, DOI 10.1046/j.1464-5491.2002.00707.x
   Lee E, 2008, BRIT J NUTR, V100, P609, DOI 10.1017/S0007114508925435
   Leskinen MH, 2005, SCAND J CLIN LAB INV, V65, P485, DOI 10.1080/00365510510025836
   Lesná IK, 2013, PHYSIOL RES, V62, P145, DOI 10.33549/physiolres.932439
   Lindgärde F, 2006, AM J CLIN NUTR, V84, P1009, DOI 10.1093/ajcn/84.5.1009
   Lottenberg AM, 2012, J NUTR BIOCHEM, V23, P1027, DOI 10.1016/j.jnutbio.2012.03.004
   Mahendran Y, 2013, DIABETES CARE, V36, P3732, DOI 10.2337/dc13-0800
   Marangoni F, 2014, ATHEROSCLEROSIS, V232, P334, DOI 10.1016/j.atherosclerosis.2013.11.048
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mayneris-Perxachs J, 2014, CLIN NUTR, V33, P90, DOI 10.1016/j.clnu.2013.03.001
   Miranda PJ, 2005, AM HEART J, V149, P33, DOI 10.1016/j.ahj.2004.07.013
   Murphy R, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/920214
   Paillard F, 2008, NUTR METAB CARDIOVAS, V18, P436, DOI 10.1016/j.numecd.2007.02.017
   Phillips CM, 2013, OBESITY, V21, pE154, DOI 10.1002/oby.20263
   Savva SC, 2013, DIABET METAB SYND OB, V6, P403, DOI 10.2147/DMSO.S34220
   Sethom MM, 2011, PROSTAG LEUKOTR ESS, V85, P137, DOI 10.1016/j.plefa.2011.06.006
   Thompson F.E., 2013, Nutrition in the prevention and treatment of disease, V3rd, P3, DOI [10.1016/B978-0-12-391884-0.00001-9, DOI 10.1016/B978-0-12-391884-0.00001-9]
   Tvrzická E, 2002, ANAL CHIM ACTA, V465, P337, DOI 10.1016/S0003-2670(02)00396-3
   Vanhala M, 2012, AM J EPIDEMIOL, V176, P253, DOI 10.1093/aje/kwr504
   Vareka T, 2012, NEUROENDOCRINOL LETT, V33, P83
   Vávrová L, 2013, OBESITY FACTS, V6, P39, DOI 10.1159/000348569
   Vessby B, 2003, CURR OPIN LIPIDOL, V14, P15, DOI 10.1097/00041433-200302000-00004
   Walsh MC, 2014, BRIT J NUTR, V111, P424, DOI 10.1017/S0007114513002602
   WARD JH, 1963, J AM STAT ASSOC, V58, P236, DOI 10.2307/2282967
   Warensjö E, 2005, DIABETOLOGIA, V48, P1999, DOI 10.1007/s00125-005-1897-x
   Warensjö E, 2006, AM J CLIN NUTR, V84, P442
   Wu JHY, 2011, AM J CLIN NUTR, V94, P431, DOI 10.3945/ajcn.111.012054
   Zák A, 2005, PHYSIOL RES, V54, P443, DOI 10.33549/physiolres.930643
   Zák A, 2007, TOHOKU J EXP MED, V212, P359, DOI 10.1620/tjem.212.359
   Zong G, 2012, AM J CLIN NUTR, V96, P970, DOI 10.3945/ajcn.112.040204
NR 45
TC 13
Z9 14
U1 0
U2 12
PU ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
PI PRAGUE 4
PA VIDENSKA 1083, PRAGUE 4 142 20, CZECH REPUBLIC
SN 0862-8408
EI 1802-9973
J9 PHYSIOL RES
JI Physiol. Res.
PY 2014
VL 63
SU 3
BP S375
EP S385
DI 10.33549/physiolres.932868
PG 11
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA AU4OO
UT WOS:000345591100008
PM 25428743
OA gold
DA 2025-06-11
ER

PT J
AU Nizami, HL
   Katare, P
   Prabhakar, P
   Kumar, Y
   Arava, SK
   Chakraborty, P
   Maulik, SK
   Banerjee, SK
AF Nizami, Hina Lateef
   Katare, Parmeshwar
   Prabhakar, Pankaj
   Kumar, Yashwant
   Arava, Sudheer Kumar
   Chakraborty, Praloy
   Maulik, Subir Kumar
   Banerjee, Sanjay Kumar
TI Vitamin D Deficiency in Rats Causes Cardiac Dysfunction by Inducing
   Myocardial Insulin Resistance
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE cardiac remodeling; heart failure; insulin resistance; metabolic
   syndrome; vitamin D deficiency
ID HIGH-FAT DIET; OXIDATIVE STRESS; METABOLIC SYNDROME; HEART-FAILURE;
   INDUCED OBESITY; ADIPOSE-TISSUE; D-RECEPTOR; HYPERTROPHY; ASSOCIATION;
   EXPRESSION
AB Scope Cause-effect relationship between vitamin D deficiency and cardiometabolic abnormalities remains undefined. The aim is to investigate the role of vitamin D deficiency in cardiac failure, through possible involvement in myocardial insulin signaling. Methods and results Male SD rats (n = 6) are fed a normal diet (Con), vitamin D-deficient diet [Con(-)], or high-fat, high fructose diet (HFHFrD) for 20 weeks. Cardiac hypertrophy and fetal gene program are confirmed in Con(-) group. Cardiac dysfunction is assessed by echocardiography. Elevated renin, TGF-beta and collagen-1 alpha mRNAs, p-ERK1/2, and perivascular fibrosis indicate cardiac remodeling in Con(-) group. Increased serum insulin, triglycerides, and blood pressure, and decreased glucose tolerance and HDL cholesterol are observed in Con(-) rats. Decreased p-Akt/Akt, GLUT4, SOD2, and catalase, and increased NF-kappa B, TNF-alpha, and IL-6 are observed in Con(-) hearts. In H9c2 cells, calcitriol attenuates palmitate-induced insulin resistance. VDR-silenced H9c2 cells show reduced Akt phosphorylation, GLUT4 translocation, and 2-NBDG uptake. Findings in Con(-) and HFHFrD groups are comparable. Conclusion Vitamin D deficiency in rats mimic high-fat-, high-fructose-induced metabolic syndrome and cardiac dysfunction. This study demonstrates that vitamin D deficiency is an independent risk factor for heart failure, at least in part, through induction of myocardial insulin resistance.
C1 [Nizami, Hina Lateef; Katare, Parmeshwar; Kumar, Yashwant; Banerjee, Sanjay Kumar] Translat Hlth Sci & Technol Inst, Drug Discovery Res Ctr, Faridabad 121001, India.
   [Prabhakar, Pankaj; Maulik, Subir Kumar] All India Inst Med Sci, Dept Pharmacol, New Delhi 110029, India.
   [Arava, Sudheer Kumar] All India Inst Med Sci, Dept Pathol, New Delhi 110029, India.
   [Chakraborty, Praloy] VMMC, Dept Cardiol, New Delhi 110029, India.
   [Chakraborty, Praloy] Safdarjang Hosp, New Delhi 110029, India.
C3 Department of Biotechnology (DBT) India; Translational Health Science &
   Technology Institute (THSTI); All India Institute of Medical Sciences
   (AIIMS) New Delhi; All India Institute of Medical Sciences (AIIMS) New
   Delhi; Vardhman Mahavir Medical College & Safdarjung Hospital; Vardhman
   Mahavir Medical College & Safdarjung Hospital
RP Banerjee, SK (corresponding author), Translat Hlth Sci & Technol Inst, Drug Discovery Res Ctr, Faridabad 121001, India.
EM skbanerjee@thsti.res.in
RI Arava, Sudheer/AAF-7593-2020; Prabhakar, Dr. Pankaj/GOH-1003-2022;
   Banaś, Elżbieta/W-4583-2017; Banerjee, Sanjay/F-2677-2019
OI Banerjee, Sanjay k/0000-0002-0044-0984; Banerjee,
   Sanjay/0000-0002-4478-7189; Banerjee, Sanjay/0000-0002-0008-0480;
   Prabhakar, Dr. Pankaj/0000-0002-1630-4258
CR Adela R, 2016, SCI REP-UK, V6, DOI 10.1038/srep37593
   Al-Musharaf S, 2018, NUTRIENTS, V10, DOI 10.3390/nu10040489
   Anhê FF, 2015, GUT, V64, P872, DOI 10.1136/gutjnl-2014-307142
   Ärnlöv J, 2001, AM HEART J, V142, P720, DOI 10.1067/mhj.2001.116957
   Aroor AR, 2012, HEART FAIL CLIN, V8, P609, DOI 10.1016/j.hfc.2012.06.005
   Bagul PK, 2012, PHARMACOL RES, V66, P260, DOI 10.1016/j.phrs.2012.05.003
   Benzler J, 2015, DIABETES, V64, P2015, DOI 10.2337/db14-0093
   Buta B, 2017, J AM GERIATR SOC, V65, P619, DOI 10.1111/jgs.14677
   Chen S, 2008, HYPERTENSION, V52, P1106, DOI 10.1161/HYPERTENSIONAHA.108.119602
   Crescenzo R, 2015, EUR J NUTR, V54, P183, DOI 10.1007/s00394-014-0699-7
   Davie AP, 1996, BRIT MED J, V312, P222
   Domenighetti AA, 2010, J MOL CELL CARDIOL, V48, P663, DOI 10.1016/j.yjmcc.2009.11.017
   Fu F, 2014, CIRCULATION, V130
   Fu F, 2015, SCI REP-UK, V5, DOI 10.1038/srep17927
   Girgis CM, 2014, ENDOCRINOLOGY, V155, P347, DOI 10.1210/en.2013-1205
   Gupta GK, 2012, EXP MOL PATHOL, V93, P82, DOI 10.1016/j.yexmp.2012.04.006
   Holick MF, 2017, REV ENDOCR METAB DIS, V18, P153, DOI 10.1007/s11154-017-9424-1
   Ilkun O, 2009, CIRCULATION, V120, pS892
   Ingelsson E, 2005, JAMA-J AM MED ASSOC, V294, P334, DOI 10.1001/jama.294.3.334
   Jolliffe DA, 2018, J STEROID BIOCHEM, V175, P88, DOI 10.1016/j.jsbmb.2016.11.004
   Karkeni E, 2018, EPIGENETICS-US, V13, P156, DOI 10.1080/15592294.2016.1276681
   Katare PB, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.00719
   Kim SM, 2014, J RENAL NUTR, V24, P20, DOI 10.1053/j.jrn.2013.07.003
   Li CY, 2007, J EPIDEMIOL COMMUN H, V61, P67, DOI 10.1136/jech.2006.048173
   Li YC, 2002, J CLIN INVEST, V110, P229, DOI [10.1172/JCI200215219, 10.1172/JCI0215219]
   Manna P, 2017, ARCH BIOCHEM BIOPHYS, V615, P22, DOI 10.1016/j.abb.2017.01.002
   Nielsen R, 2018, J NUCL CARDIOL, V25, P169, DOI 10.1007/s12350-016-0622-0
   Ouwens DM, 2005, DIABETOLOGIA, V48, P1229, DOI 10.1007/s00125-005-1755-x
   Park S, 2016, J NUTR BIOCHEM, V27, P257, DOI 10.1016/j.jnutbio.2015.09.013
   Perrone-Filardi P, 2015, EUR HEART J, V36, P2630, DOI 10.1093/eurheartj/ehv350
   Schultz O, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0014328
   Sena S, 2009, J MOL CELL CARDIOL, V46, P910, DOI 10.1016/j.yjmcc.2009.02.014
   Stansfield WE., 2014, Cellular and Molecular Pathobiology of Cardiovascular Disease, P51, DOI [10.1016/B978- 0-12-405206- 2.00004-1, DOI 10.1016/B978-0-12-405206-2.00004-1, 10.1016/b978-0-12-405206-2.00004-1]
   Taegtmeyer H, 2010, ANN NY ACAD SCI, V1188, P191, DOI 10.1111/j.1749-6632.2009.05100.x
   Tan Y, 2011, DIABETES, V60, P625, DOI 10.2337/db10-1164
   Tare M, 2011, J PHYSIOL-LONDON, V589, P4777, DOI 10.1113/jphysiol.2011.214726
   Wang O, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0118135
   Wimalawansa SJ, 2018, J STEROID BIOCHEM, V175, P60, DOI 10.1016/j.jsbmb.2016.09.016
   Witteles RM, 2008, J AM COLL CARDIOL, V51, P93, DOI 10.1016/j.jacc.2007.10.021
   Xiang W, 2005, AM J PHYSIOL-ENDOC M, V288, pE125, DOI 10.1152/ajpendo.00224.2004
NR 40
TC 26
Z9 26
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD SEP
PY 2019
VL 63
IS 17
AR 1900109
DI 10.1002/mnfr.201900109
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA IX8IZ
UT WOS:000485931500010
PM 31095894
DA 2025-06-11
ER

PT J
AU Wu, HT
   Liu, CC
   Dong, JH
   Lai, CJ
   Chen, DY
   Sun, CK
   Chen, JJ
AF Wu, Hsien-Tsai
   Liu, Cyuan-Cin
   Dong, Jyun-Hao
   Lai, Ching Jung
   Chen, Ding-Yuan
   Sun, Cheuk-Kwan
   Chen, Jian-Jung
TI CAROTENOIDS IN RELATION TO MARKERS OF ENDOTHELIAL FUNCTION AND
   ATHEROSCLEROSIS IN YOUNG PEOPLE
SO CURRENT TOPICS IN NUTRACEUTICAL RESEARCH
LA English
DT Article
DE Arterial stiffness; Cardiovascular disease; Carotenoids; Endothelial
   function
ID CORONARY-HEART-DISEASE; PULSE-WAVE VELOCITY; METABOLIC SYNDROME;
   ARTERIAL STIFFNESS; PLASMA CAROTENOIDS; SERUM CAROTENOIDS; OXIDATIVE
   STRESS; ADULTS; VITAMINS; RISK
AB This study aimed at observing the relationship between carotenoids status, parameters of metabolic syndrome, and vascular health prior to changing their dietary condition, i.e. eating out. This study consisted of two parts. In Part A study, the skin carotenoids counts (SCC) of three different groups, Group I: young people (n=20), Group 2: upper mid-aged people (n=14), and Group 3: diabetics (n=17), were obtained and compared Although Group I appeared to be the youngest, the SCC was much lower than that of Group 2 (19619 +/- 11147 vs. 32571 +/- 4351) but close to that of Group 3 (18974 +/- 9089). As far as vascular health was concerned it was not statistically different between Group I and Group 2 In Part B study, SCC, pulse wave velocity (PWVfoot), and dilatation index (DI) of healthy young subjects (Group 4, n=14) were measured for three consecutive months with their dietary condition remaining unchanged Although there was no significant difference between the abovementioned values, the SCC were still significantly correlated with the parameters of metabolic syndrome factor and PWVfoot (r=-0.435, P=0.001). With their dietary condition remaining unchanged for three consecutive months, Group 4 exhibited no significant improvement in either the SCC or parameters of vascular health.
C1 [Wu, Hsien-Tsai; Liu, Cyuan-Cin; Dong, Jyun-Hao] Natl Dong Hwa Univ, Dept Elect Engn, Hualien, Taiwan.
   [Lai, Ching Jung] Tzu Chi Univ, Sch Med, Dept Physiol, Hualien, Taiwan.
   [Chen, Ding-Yuan] Hualien Hosp, Dept Urol, Hualien, Taiwan.
   [Sun, Cheuk-Kwan] I Shou Univ, E Da Hosp, Dept Emergency Med, Kaohsiung, Taiwan.
   [Chen, Jian-Jung] Buddhist Tzu Chi Gen Hosp, Taichung Branch, Dept Chinese Med, Taichung, Taiwan.
   [Chen, Jian-Jung] Tzu Chi Univ, Sch Chinese Med, Hualien, Taiwan.
C3 National Dong Hwa University; Tzu Chi University; I Shou University;
   E-Da Hospital; Buddhist Tzu Chi General Hospital; Taichung Tzu Chi
   Hospital; Tzu Chi University
RP Chen, JJ (corresponding author), Tzu Chi Univ, Dept Chinese Med, Buddhist Tzu Chi Gen Hosp, Taichung Branch, 66,Sec 1,Fongsing Rd, Tanzih Township 427, Taichung County, Taiwan.
EM hsientsaiwu@gmail.com; cjjwei@ms34.hinet.net
RI Wu, Hsien-Tsai/X-4730-2019; CHEN, Jianhui/D-1338-2009; Sun,
   Cheuk-Kwan/K-5723-2012
OI Wu, Hsientsai/0000-0002-2581-9384
FU National Science Council, Taiwan, Republic of China [NSC
   100-2221-E-259-030-MY2]; National Dong Hwa University on campus
   interdisciplinary integration project [101T924-3, 102T931-3]
FX The authors would like to thank the volunteers involved in this study
   for allowing us to collect and analyze their data. This research was
   partly supported by National Science Council under Grand NSC
   100-2221-E-259-030-MY2, Taiwan, Republic of China and National Dong Hwa
   University on campus interdisciplinary integration project no. 101T924-3
   and 102T931-3.
CR Beckman JA, 2003, AM J PHYSIOL-HEART C, V285, pH2392, DOI 10.1152/ajpheart.00403.2003
   Bowman SA, 2004, J AM COLL NUTR, V23, P163, DOI 10.1080/07315724.2004.10719357
   Bustos P, 2007, NUTR METAB CARDIOVAS, V17, P581, DOI 10.1016/j.numecd.2006.06.001
   Chung H K, 2009, Nutr Metab Cardiovasc Dis, V19, pe9, DOI 10.1016/j.numecd.2009.03.013
   Ermakov IV, 2001, OPT LETT, V26, P1179, DOI 10.1364/OL.26.001179
   Fletcher RH, 2002, JAMA-J AM MED ASSOC, V287, P3127, DOI 10.1001/jama.287.23.3127
   Flood A, 2000, JNCI-J NATL CANCER I, V92, P1706, DOI 10.1093/jnci/92.21.1706
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hata TR, 2000, J INVEST DERMATOL, V115, P441, DOI 10.1046/j.1523-1747.2000.00060.x
   Hingorani AD, 2000, CIRCULATION, V102, P994, DOI 10.1161/01.CIR.102.9.994
   Hung CS, 2009, NUTR METAB CARDIOVAS, V19, P241, DOI 10.1016/j.numecd.2008.07.006
   Kimmons Joel E, 2006, MedGenMed, V8, P59
   Koh WP, 2011, NUTR METAB CARDIOVAS, V21, P685, DOI 10.1016/j.numecd.2009.12.005
   Kontush A, 2005, ATHEROSCLEROSIS, V182, P277, DOI 10.1016/j.atherosclerosis.2005.03.001
   Larson N, 2011, J AM DIET ASSOC, V111, P1696, DOI 10.1016/j.jada.2011.08.007
   Lin YJ, 2007, ASIA PAC J CLIN NUTR, V16, P616
   Morrison HI, 1996, JAMA-J AM MED ASSOC, V275, P1893, DOI 10.1001/jama.275.24.1893
   Omenn GS, 1996, NEW ENGL J MED, V334, P1150, DOI 10.1056/NEJM199605023341802
   Patel RS, 2011, ATHEROSCLEROSIS, V218, P90, DOI 10.1016/j.atherosclerosis.2011.04.033
   Rimm EB, 1998, JAMA-J AM MED ASSOC, V279, P359, DOI 10.1001/jama.279.5.359
   Scuteri A, 2008, NUTR METAB CARDIOVAS, V18, P349, DOI 10.1016/j.numecd.2007.03.008
   Smidt C. R., 2004, Current Topics in Nutraceutical Research, V2, P79
   Smidt CR, 2003, FASEB J, V17, pA1115
   Suzuki K, 2011, CLIN NUTR, V30, P369, DOI 10.1016/j.clnu.2010.12.006
   Takase B, 2004, ANGIOLOGY, V55, P653, DOI 10.1177/000331970405500606
   van Herpen-Broekmans WMR, 2004, EUR J EPIDEMIOL, V19, P915, DOI 10.1007/s10654-004-5760-z
   Voutilainen S, 2006, AM J CLIN NUTR, V83, P1265
   Wu HT, 2012, BLOOD PRESSURE, V21, P167, DOI 10.3109/08037051.2012.681853
   Wu HT, 2012, IEEE T INSTRUM MEAS, V61, P162, DOI 10.1109/TIM.2011.2159416
   Wu HT, 2011, ANN BIOMED ENG, V39, P2857, DOI 10.1007/s10439-011-0342-1
   Zidichouski JA, 2009, J AM COLL NUTR, V28, P687, DOI 10.1080/07315724.2009.10719802
NR 31
TC 0
Z9 0
U1 0
U2 2
PU NEW CENTURY HEALTH PUBLISHERS, LLC
PI COPPELL
PA PO BOX 175, COPPELL, TX 75019 USA
SN 1540-7535
J9 CURR TOP NUTRACEUT R
JI Curr. Top. Nutraceutical Res.
PD AUG
PY 2013
VL 11
IS 3
BP 83
EP 90
PG 8
WC Nutrition & Dietetics; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Pharmacology & Pharmacy
GA AF3ZE
UT WOS:000334650400003
DA 2025-06-11
ER

PT J
AU Gauthier, H
   Zedet, M
   Wahab, A
   Baldé, S
   Bapst, B
   Lafont, C
   Créange, A
AF Gauthier, H.
   Zedet, M.
   Wahab, A.
   Balde, S.
   Bapst, B.
   Lafont, C.
   Creange, A.
TI Metabolic syndrome and the phenotype of multiple
SO REVUE NEUROLOGIQUE
LA English
DT Article
DE Multiple sclerosis; Metabolic syndrome; Relapsing-remitting multiple;
   sclerosis; Secondary progressive multiple; Abdominal obesity; Waist
   circumference
ID OXIDATIVE STRESS; SCLEROSIS; COMORBIDITY; PROGRESSION; PREVALENCE;
   DIAGNOSIS; DISEASE; DAMAGE
AB Background. - Comorbidities, particularly vascular comorbidities, have been shown to exacerbate the progression of disability in multiple sclerosis (MS). Metabolic syndrome (MetS) is a cluster of conditions including abdominal obesity, insulin resistance, atherogenic dyslipidemia, and vascular dysfunction, which contribute to vascular morbidity and chronic inflammation. Objective. - To describe the characteristics of MetS in a cohort of MS patients and evaluate its relationship with the MS phenotype. Methods. - A monocentric cohort study was conducted on MS patients, collecting demographic, clinical, radiological, and therapeutic data, as well as metabolic data including waist circumference, blood pressure, serum triglycerides, high-density lipoprotein cholesterol, and fasting blood glucose. Results. - Among the 84 patients included in the study, 27% were diagnosed with MetS. MetS was found to be associated with secondary progressive MS (SPMS). Patients with SPMS had a higher prevalence of MetS compared to those with relapsing-remitting MS (RRMS), even after adjusting for disease duration. While MetS was associated with Expanded Disability Status Scale (EDSS) progression in the 3-year period according to univariate analysis, it did not show a significant association with disease activity. Conclusion. - This study provides evidence supporting the connection between MetS and the progression of disability in MS, independent of disease relapse activity. (c) 2024 The Authors. Published by Elsevier Masson SAS. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
C1 [Gauthier, H.; Zedet, M.; Wahab, A.; Creange, A.] Hop Henri Mondor, Ctr hosp Univ Henri Mondor, AP HP, Serv neurol, 51 Ave Marechal Delattre Detassigny, F-94010 Creteil, France.
   [Gauthier, H.; Zedet, M.; Wahab, A.; Balde, S.; Bapst, B.; Creange, A.] Hop Henri Mondor, AP HP, Creteil, Paris, France.
   [Zedet, M.; Wahab, A.; Bapst, B.; Creange, A.] Univ Paris Est, EA4391, Creteil, France.
   [Bapst, B.] Hop Henri Mondor, AP HP, Serv neuroradiol, Creteil, France.
   [Lafont, C.] Univ Paris Est Creteil, Inserm, IMRB, F-94010 Creteil, France.
   [Lafont, C.] Hop Henri Mondor, AP HP, Serv Sante publ, F-94010 Creteil, France.
C3 Assistance Publique Hopitaux Paris (APHP); Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Hopital Universitaire
   Henri-Mondor - APHP; Universite Paris-Est-Creteil-Val-de-Marne (UPEC);
   Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Henri-Mondor - APHP; Universite Paris-Est-Creteil-Val-de-Marne (UPEC);
   Assistance Publique Hopitaux Paris (APHP); Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Hopital Universitaire
   Henri-Mondor - APHP; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Paris-Est-Creteil-Val-de-Marne (UPEC);
   Assistance Publique Hopitaux Paris (APHP); Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Hopital Universitaire
   Henri-Mondor - APHP
RP Créange, A (corresponding author), Hop Henri Mondor, Ctr hosp Univ Henri Mondor, AP HP, Serv neurol, 51 Ave Marechal Delattre Detassigny, F-94010 Creteil, France.
RI Lafont, Charlotte/LGY-4215-2024
FU French State by the "Agence Nationale de la Recherche"
   [ANR-10-COHO-002]; Eugene Devic EDMUS Foundation; ARSEP Foundation
FX The authors thank the Observatoire francais de la Sclerose en plaques
   (OFSEP) which is supported by a grant provided by the French State and
   handled by the "Agence Nationale de la Recherche", within the framework
   of the "Investments for the Future" program, under the reference
   ANR-10-COHO-002, by the Eugene Devic EDMUS Foundation against multiple
   sclerosis and by the ARSEP Foundation.
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Bergaglio T, 2021, FRONT CELL NEUROSCI, V15, DOI 10.3389/fncel.2021.610295
   Cameron AJ, 2004, ENDOCRIN METAB CLIN, V33, P351, DOI 10.1016/j.ecl.2004.03.005
   Campbell GR, 2014, MULT SCLER J, V20, P1806, DOI 10.1177/1352458514544537
   Chai JW, 2014, CELL BIOCHEM BIOPHYS, V70, P1783, DOI 10.1007/s12013-014-0129-8
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   CONFAVREUX C, 1992, J NEUROL NEUROSUR PS, V55, P671, DOI 10.1136/jnnp.55.8.671
   Corp NIS, 2017, IBM SPSS statistics for windows, version 25
   Dendrou CA, 2015, NAT REV IMMUNOL, V15, P545, DOI 10.1038/nri3871
   Devaraj S., 2008, Diabetes Pathophysiology, P32, DOI [10.17925/USE.2008.04.2.32, DOI 10.17925/USE.2008.04.2.32]
   Fahmi RM, 2020, MULT SCLER RELAT DIS, V44, DOI 10.1016/j.msard.2020.102336
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Guo CY, 2013, NEURAL REGEN RES, V8, P2003, DOI 10.3969/j.issn.1673-5374.2013.21.009
   Gustafson DR, 2007, J INTERN MED, V262, P643, DOI 10.1111/j.1365-2796.2007.01869.x
   Kappos L, 2020, JAMA NEUROL, V77, P1132, DOI 10.1001/jamaneurol.2020.1568
   Kappos L, 2016, MULT SCLER J, V22, P1297, DOI 10.1177/1352458515616701
   Kowalec K, 2017, NEUROLOGY, V89, P2455, DOI 10.1212/WNL.0000000000004716
   Lee HY, 2013, ATHEROSCLEROSIS, V230, P177, DOI 10.1016/j.atherosclerosis.2013.07.037
   Lorscheider J, 2016, BRAIN, V139, P2395, DOI 10.1093/brain/aww173
   Lublin FD, 2014, NEUROLOGY, V83, P278, DOI 10.1212/WNL.0000000000000560
   Marrie RA, 2010, NEUROLOGY, V74, P1041, DOI 10.1212/WNL.0b013e3181d6b125
   Marrie RA, 2015, MULT SCLER J, V21, P318, DOI 10.1177/1352458514564485
   Miller D, 2009, LANCET NEUROL, V8, P699, DOI 10.1016/S1474-4422(07)70243-0
   Pinhas-Hamiel O, 2015, EUR J NEUROL, V22, P1275, DOI 10.1111/ene.12738
   Sicras-Mainar A, 2017, BMC NEUROL, V17, DOI 10.1186/s12883-017-0914-2
   Smith KJ, 2007, BRAIN PATHOL, V17, P230, DOI 10.1111/j.1750-3639.2007.00066.x
   STYS PK, 1990, P NATL ACAD SCI USA, V87, P4212, DOI 10.1073/pnas.87.11.4212
   Tettey P, 2014, J NEUROL SCI, V347, P23, DOI 10.1016/j.jns.2014.10.020
   Thompson AJ, 2018, LANCET, V391, P1622, DOI 10.1016/S0140-6736(18)30481-1
   Thompson AJ, 2018, LANCET NEUROL, V17, P162, DOI 10.1016/S1474-4422(17)30470-2
   Van Dyken P, 2018, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00930
   Vukusic S, 2010, PRESSE MED, V39, P359, DOI 10.1016/j.lpm.2009.11.008
   Weinstock-Guttman B, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-127
   Wiendl H, 2021, THER ADV NEUROL DISO, V14, DOI 10.1177/17562864211039648
   Zhang XC, 2005, EXP NEUROL, V191, P318, DOI 10.1016/j.expneurol.2004.10.011
NR 35
TC 1
Z9 1
U1 0
U2 0
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0035-3787
EI 2213-0004
J9 REV NEUROL-FRANCE
JI Rev. Neurol.
PD SEP
PY 2024
VL 180
IS 7
BP 673
EP 681
DI 10.1016/j.neurol.2024.03.009
EA AUG 2024
PG 9
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA E0O8K
UT WOS:001300094900001
PM 38729781
OA hybrid
DA 2025-06-11
ER

PT J
AU Yorulmaz, E
   Uzunlulu, M
   Yorulmaz, H
   Oguz, A
AF Yorulmaz, Elif
   Uzunlulu, Mehmet
   Yorulmaz, Hatice
   Oguz, Aytekin
TI Relationship between uric acid levels and impaired glucose tolerance in
   subjects with metabolic syndrome
SO PAKISTAN JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE Metabolic syndrome; Uric acid; Glucose intolerance
ID CARDIOVASCULAR RISK-FACTORS; MORTALITY; ATHEROSCLEROSIS; PREVALENCE;
   RESISTANCE; DISEASE; STRESS; MEN
AB Objective: Metabolic syndrome (MetS) is a clustering of cardio-metabolic risk factors. Elevated serum uric acid levels are frequent in cases with cardiovascular disease carrying many attributes of MetS. The role of uric acid in the MetS pathogenesis and the development of Type 2 Diabetes Mellitus (DM) was not fully understood. In this study, the relationship between serum uric acid levels and MetS criteria and oral glucose tolerance test (OGTT) results was studied.
   Methodology: This study was carried out in 83 patients having at least three MetS diagnosis criteria recommended by National Cholesterol Education Program Adult Treatment Panel III. After collecting 12-hour fasting venous blood samples of subjects, 2-hour OGTT was performed with 75 g oral glucose. A glucose level between 140 and 199 mg/dl at hour 2 was defined as impaired glucose tolerance.
   Results: The 2-hour glucose value of 25 cases (31%) out of 83 cases was determined to be 140 mg/dl and over. In the multiple linear regression analysis, it was found that uric acid level and waist circumference, and body mass index and 2-hour OGTT levels were significantly related.
   Conclusion: In this study, in cases having high risk for type 2 DM, it was found that uric acid levels were related by some MetS components. Uric acid concentrations did not effect basal glycemia and insulin sensitivity.
C1 [Yorulmaz, Elif] Goztepe Training & Res Hosp, Dept Gastroenterol, Istanbul, Turkey.
   [Uzunlulu, Mehmet; Oguz, Aytekin] Goztepe Training & Res Hosp, Dept Internal Med, Istanbul, Turkey.
   [Yorulmaz, Hatice] Halic Univ, Sch Hlth Sci, Dept Physiotherapy, Istanbul, Turkey.
   [Yorulmaz, Hatice] Halic Univ, Sch Hlth Sci, Dept Rehabil, Istanbul, Turkey.
C3 Istanbul Goztepe Training & Research Hospital; Istanbul Goztepe Training
   & Research Hospital; Halic University; Halic University
RP Yorulmaz, H (corresponding author), Daruleceze Ave,14 Okmeydani, Istanbul, Turkey.
EM haticeyorulmaz@gmail.com
RI Uzunlulu, Mehmet/KYR-8040-2024; Oguz, Aytekin/AAJ-2732-2021
CR [Anonymous], 2004, DIABETES CARE, V27, pS11, DOI [10.2337/diacare.27.2007.S11, DOI 10.2337/DIACARE.27.2007.S11]
   Bedir A, 2003, JPN HEART J, V44, P527, DOI 10.1536/jhj.44.527
   Bonora E, 1996, INT J OBESITY, V20, P975
   Borch-Johnsen K, 2001, ARCH INTERN MED, V161, P397, DOI 10.1001/archinte.161.3.397
   Chou PS, 1998, DIABETES CARE, V21, P1183, DOI 10.2337/diacare.21.7.1183
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Conen D, 2004, BMC PUBLIC HEALTH, V4, DOI 10.1186/1471-2458-4-9
   Culleton BF, 1999, ANN INTERN MED, V131, P7, DOI 10.7326/0003-4819-131-1-199907060-00003
   FACCHINI F, 1991, JAMA-J AM MED ASSOC, V266, P3008, DOI 10.1001/jama.266.21.3008
   Fang J, 2000, JAMA-J AM MED ASSOC, V283, P2404, DOI 10.1001/jama.283.18.2404
   Feig DI, 2008, NEW ENGL J MED, V359, P1811, DOI 10.1056/NEJMra0800885
   Hayden MR, 2002, CARDIOVASC DIABETOL, V1, DOI 10.1186/1475-2840-1-3
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Kekäläinen P, 2000, METABOLISM, V49, P1247, DOI 10.1053/meta.2000.9514
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mori Y, 2006, ENDOCRINE, V29, P351, DOI 10.1385/ENDO:29:2:351
   Niskanen LK, 2004, ARCH INTERN MED, V164, P1546, DOI 10.1001/archinte.164.14.1546
   Rao SS, 2004, AM FAM PHYSICIAN, V69, P1961
   Rathmann W, 2007, EUR J EPIDEMIOL, V22, P439, DOI 10.1007/s10654-007-9132-3
   Shelmadine B, 2009, ANATOL J CARDIOL, V9, P385
   Sinha R, 2002, NEW ENGL J MED, V346, P802, DOI 10.1056/NEJMoa012578
   Williamson JR, 1999, DIABETES RES CLIN PR, V45, P81
NR 22
TC 0
Z9 0
U1 0
U2 0
PU PROFESSIONAL MEDICAL PUBLICATIONS
PI SADDAR
PA PANORAMA CENTRE, RM 522, 5TH FLOOR, BLDG 2, RAJA GHAZANFAR ALI RD, PO
   BOX 8766, SADDAR, KARACHI 00000, PAKISTAN
SN 1682-024X
J9 PAK J MED SCI
JI Pak. J. Med. Sci.
PD APR-JUN
PY 2011
VL 27
IS 2
BP 286
EP 289
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 780BX
UT WOS:000291827700013
DA 2025-06-11
ER

PT J
AU Toblli, JE
   Ferrini, MG
   Cao, G
   Vernet, D
   Angerosa, M
   Gonzalez-Cadavid, NF
AF Toblli, Jorge E.
   Ferrini, Monica G.
   Cao, Gabriel
   Vernet, Dolores
   Angerosa, Margarita
   Gonzalez-Cadavid, Nestor F.
TI Antifibrotic effects of pioglitazone on the kidney in a rat model of
   type 2 diabetes mellitus
SO NEPHROLOGY DIALYSIS TRANSPLANTATION
LA English
DT Article
DE diabetic nephropathy; fibrosis; inflammation; oxidative stress;
   thiazolidinediones
ID OBESE ZUCKER RATS; RECEPTOR-GAMMA AGONIST; CORPORAL VENOOCCLUSIVE
   DYSFUNCTION; PLASMINOGEN-ACTIVATOR INHIBITOR-1; CONVERTING
   ENZYME-INHIBITION; FATTY RATS; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; RENAL PROTECTION
AB Background. Recent evidence suggests that treatment of type 2 diabetes with thiazolidinediones [peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonists], ameliorates glomerulosclerosis and tubulointerstitial fibrosis in the rat kidney. In the current work, we have investigated whether these drugs, and specifically pioglitazone (PGT), act by preventing fibrosis and kidney dysfunction mainly through antioxidant and anti-inflammatory effects, independently of glycaemic control.
   Methods. Male 2- to 3-month-old obese Zucker fa/fa (OZR) and ZDF fa/fa rats (ZDFR), and their control the lean Zucker rat (LZR), were used. Diabetic rats were given either a low dose (0.6 mg/kg/day) or a high dose (12 mg/kg/day) of PGT in the chow for 2 or 4-5 months. Glycaemia, blood pressure, creatinine clearance and proteinuria were determined, and the underlying histopathology was defined with markers of fibrosis, glomerular damage, oxidative stress and inflammation by immunohistochemistry/quantitative image analysis in tissue sections, and western blots and ad hoc assays in fresh tissue.
   Results. PGT at low doses given for 4-5 months considerably reduced blood pressure, proteinuria and creatinine clearance. This was associated with amelioration of renal tissue damage and fibrosis, evidenced by the glomerulosclerosis, tubulointerstitial fibrosis, tubular atrophy and podocyte injury indexes, and of oxidative stress and inflammation, as shown by the decrease in the respective markers, although glycaemia remained high and obesity was not affected.
   Conclusions. These results indicate that low doses of PGT ameliorate renal fibrosis and preserve renal function in this animal model of metabolic syndrome, independently of glycaemic control or effects on body weight.
C1 [Ferrini, Monica G.; Vernet, Dolores; Gonzalez-Cadavid, Nestor F.] Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Urol Res Lab, Torrance, CA 90509 USA.
   [Toblli, Jorge E.; Cao, Gabriel; Angerosa, Margarita] Hosp Aleman, Expt Med Lab, Buenos Aires, DF, Argentina.
   [Ferrini, Monica G.; Vernet, Dolores; Gonzalez-Cadavid, Nestor F.] Charles Drew Univ, Dept Internal Med, Torrance, CA USA.
   [Gonzalez-Cadavid, Nestor F.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Urol, Torrance, CA USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; Lundquist
   Institute; University of Buenos Aires; University of Buenos Aires
   Hospital; Hospital Aleman; Charles R. Drew University of Medicine &
   Science; University of California System; University of California Los
   Angeles; University of California Los Angeles Medical Center; David
   Geffen School of Medicine at UCLA
RP Gonzalez-Cadavid, NF (corresponding author), Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Urol Res Lab, Torrance, CA 90509 USA.
EM ncadavid@ucla.edu
RI Cao, Gabriel/LJL-8755-2024
FU Takeda Pharmaceuticals North America, Inc.; American Diabetes
   Association [7-05-RA-44 ADA];  [NIHR01 DK53069]
FX This work was supported by an investigator-initiated grant from Takeda
   Pharmaceuticals North America, Inc., and (in part) American Diabetes
   Association grant #7-05-RA-44 ADA, and NIHR01 DK53069 to N.G.C.
CR Abe M, 2008, CLIN NEPHROL, V70, P220
   Agarwal R, 2005, KIDNEY INT, V68, P285, DOI 10.1111/j.1523-1755.2005.00416.x
   Baylis C, 2003, J PHARMACOL EXP THER, V307, P854, DOI 10.1124/jpet.103.055616
   Becker J, 2006, FUND CLIN PHARMACOL, V20, P429, DOI 10.1111/j.1472-8206.2006.00425.x
   Biesenbach G, 2007, CURR DIABETES REV, V3, P123, DOI 10.2174/157339907780598234
   Buckingham RE, 2005, HEPATOL RES, V33, P167, DOI 10.1016/j.hepres.2005.09.027
   Buckingham RE, 1998, DIABETES, V47, P1326, DOI 10.2337/diabetes.47.8.1326
   CLARK JB, 1983, P SOC EXP BIOL MED, V173, P68
   Dominguez JH, 2006, KIDNEY INT, V69, P1969, DOI 10.1038/sj.ki.5000406
   Dominguez J, 2007, AM J PHYSIOL-RENAL, V293, pF670, DOI 10.1152/ajprenal.00021.2007
   Ferrini MG, 2004, CARDIOVASC RES, V61, P796, DOI 10.1016/j.cardiores.2003.12.006
   Ferrini MG, 2009, J SEX MED, V6, P415, DOI 10.1111/j.1743-6109.2008.01105.x
   Glassock RJ, 2008, NEPHRON CLIN PRACT, V110, pC39, DOI 10.1159/000151244
   Gupta S, 2008, AM J NEPHROL, V28, P607, DOI 10.1159/000117311
   Hoshi S, 2002, LAB INVEST, V82, P25, DOI 10.1038/labinvest.3780392
   Katavetin Pisut, 2006, Journal of the Medical Association of Thailand, V89, P170
   KOVANECZ I, 2009, BJU INT         0109
   Kovanecz I, 2007, BJU INT, V100, P867, DOI 10.1111/j.1464-410X.2007.07070.x
   Kovanecz I, 2006, BJU INT, V98, P116, DOI 10.1111/j.1464-410X.2006.06268.x
   Lavaud S, 2001, AM J PHYSIOL-RENAL, V280, pF683, DOI 10.1152/ajprenal.2001.280.4.F683
   Lee HB, 2005, NEPHROLOGY, V10, pS11, DOI 10.1111/j.1440-1797.2005.00449.x
   Li YH, 2008, DIABETES-METAB RES, V24, P498, DOI 10.1002/dmrr.874
   McCarthy KJ, 2000, KIDNEY INT, V58, P2341, DOI 10.1046/j.1523-1755.2000.00418.x
   Nakamura T, 2001, METABOLISM, V50, P1193, DOI 10.1053/meta.2001.26703
   Nakamura T, 2006, DIABETES-METAB RES, V22, P385, DOI 10.1002/dmrr.633
   Namikoshi T, 2008, HYPERTENS RES, V31, P745, DOI 10.1291/hypres.31.745
   Panchapakesan U, 2005, NAT CLIN PRACT NEPHR, V1, P33, DOI 10.1038/ncpneph0029
   Panchapakesan U, 2005, AM J PHYSIOL-RENAL, V289, pF1153, DOI 10.1152/ajprenal.00097.2005
   Peterson R.G., 1990, ILAR NEWS, V32, P16, DOI DOI 10.1093/ILAR.32.3.16
   Poirier B, 2000, NEPHROL DIAL TRANSPL, V15, P467, DOI 10.1093/ndt/15.4.467
   Qian Y, 2008, DIABETES, V57, P1439, DOI 10.2337/db08-0061
   Rizos CV, 2008, EXPERT OPIN PHARMACO, V9, P1087, DOI 10.1517/14656566.9.7.1087
   Rodriguez WE, 2006, AM J PHYSIOL-RENAL, V291, pF694, DOI 10.1152/ajprenal.00398.2005
   ROSSI R, 1995, BBA-GEN SUBJECTS, V1243, P230, DOI 10.1016/0304-4165(94)00133-I
   Sarafidis PA, 2008, CURR OPIN NEPHROL HY, V17, P450, DOI 10.1097/MNH.0b013e328305b994
   Schernthaner G, 2008, NEPHROL DIAL TRANSPL, V23, P1112, DOI 10.1093/ndt/gfn060
   Simonson MS, 2007, KIDNEY INT, V71, P846, DOI 10.1038/sj.ki.5002180
   Suzaki Y, 2007, INT J BIOL SCI, V3, P40
   Swaminathan S, 2008, CURR OPIN NEPHROL HY, V17, P143, DOI 10.1097/MNH.0b013e3282f4e539
   Toblli JE, 2005, HEART, V91, P80, DOI 10.1136/hrt.2003.022707
   Toblli JE, 2004, KIDNEY INT, V65, P2343, DOI 10.1111/j.1523-1755.2004.00661.x
   Toblli JE, 2008, OBESITY, V16, P770, DOI 10.1038/oby.2007.114
   Toblli JE, 2006, OBESITY, V14, P1586, DOI 10.1038/oby.2006.183
   Valente EGA, 2003, NITRIC OXIDE-BIOL CH, V9, P229, DOI 10.1016/j.niox.2003.12.002
   Wada K, 2006, J BIOL CHEM, V281, P12673, DOI 10.1074/jbc.M513786200
   Werner C, 2007, DIABETES, V56, P2609, DOI 10.2337/db07-0069
   Zafiriou S, 2005, J AM SOC NEPHROL, V16, P638, DOI 10.1681/ASN.2004040278
   Zafiriou S, 2004, KIDNEY INT, V65, P1647, DOI 10.1111/j.1523-1755.2004.00574.x
NR 48
TC 54
Z9 65
U1 0
U2 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0931-0509
EI 1460-2385
J9 NEPHROL DIAL TRANSPL
JI Nephrol. Dial. Transplant.
PD AUG
PY 2009
VL 24
IS 8
BP 2384
EP 2391
DI 10.1093/ndt/gfp103
PG 8
WC Transplantation; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Transplantation; Urology & Nephrology
GA 472FN
UT WOS:000268115400016
PM 19297362
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Klobucar, I
   Hofmann, L
   Habisch, H
   Lechleitner, M
   Klobucar, L
   Trbusic, M
   Pregartner, G
   Berghold, A
   Madl, T
   Frank, S
   Degoricija, V
AF Klobucar, Iva
   Hofmann, Lidija
   Habisch, Hansjoerg
   Lechleitner, Margarete
   Klobucar, Lucija
   Trbusic, Matias
   Pregartner, Gudrun
   Berghold, Andrea
   Madl, Tobias
   Frank, Sasa
   Degoricija, Vesna
TI Advanced Oxidation Protein Products Are Strongly Associated with the
   Serum Levels and Lipid Contents of Lipoprotein Subclasses in Healthy
   Volunteers and Patients with Metabolic Syndrome
SO ANTIOXIDANTS
LA English
DT Article
DE NMR spectroscopy; lipoprotein profiling; advanced oxidation protein
   products; metabolic syndrome
ID DENSE HDL3 PARTICLES; IN-VITRO OXIDATION; RISK-FACTORS; STRESS;
   SUSCEPTIBILITY; LDL; ATHEROSCLEROSIS; HETEROGENEITY; SUBFRACTIONS;
   COMPONENTS
AB The association between advanced oxidation protein products (AOPPs) and lipoprotein subclasses remains unexplored. Therefore, we performed comprehensive lipoprotein profiling of serum using NMR spectroscopy and examined the associations of lipoprotein subclasses with the serum levels of AOPPs in healthy volunteers (HVs) and patients with metabolic syndrome (MS). The serum levels of AOPPs were significantly positively correlated with the serum levels of very-low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), and low-density lipoprotein (LDL); however, they were significantly negatively correlated with high-density lipoprotein (HDL). These lipoproteins (and their subclasses) differed markedly regarding the direction of correlations between their lipid contents and AOPPs. The strength of the correlations and the relative contributions of the subclasses to the correlations were different in the HVs and patients with MS. As revealed by orthogonal partial least squares discriminant analyses, the serum levels of IDL were strong determinants of AOPPs in the HVs, whereas the serum levels of VLDL and the lipid content of LDL were strong determinants in both groups. We conclude that IDL, VLDL, and LDL facilitate, whereas HDL diminishes the bioavailability of serum AOPPs. The presence of MS and the lipid contents of the subclasses affect the relationship between lipoproteins and AOPPs.
C1 [Klobucar, Iva; Trbusic, Matias] Sisters Char Univ Hosp Ctr, Dept Cardiol, Zagreb 10000, Croatia.
   [Hofmann, Lidija] FH JOANNEUM Univ Appl Sci, Inst Biomed Sci, Dept Hlth Studies, A-8020 Graz, Austria.
   [Habisch, Hansjoerg; Madl, Tobias] Med Univ Graz, Otto Loewi Res Ctr, Med Chem, A-8010 Graz, Austria.
   [Lechleitner, Margarete; Frank, Sasa] Med Univ Graz, Gottfried Schatz Res Ctr, Mol Biol & Biochem, A-8010 Graz, Austria.
   [Klobucar, Lucija] Univ Hosp Ctr Osijek, Dept Med, Osijek 31000, Croatia.
   [Trbusic, Matias; Degoricija, Vesna] Univ Zagreb, Sch Med, Zagreb 10000, Croatia.
   [Pregartner, Gudrun; Berghold, Andrea] Med Univ Graz, Inst Med Informat Stat & Documentat, A-8036 Graz, Austria.
   [Madl, Tobias; Frank, Sasa] BioTechMed Graz, A-8010 Graz, Austria.
   [Degoricija, Vesna] Sisters Char Univ Hosp Ctr, Dept Med, Zagreb 10000, Croatia.
C3 Medical University of Graz; Medical University of Graz; University of
   Zagreb; Medical University of Graz
RP Frank, S (corresponding author), Med Univ Graz, Gottfried Schatz Res Ctr, Mol Biol & Biochem, A-8010 Graz, Austria.; Frank, S (corresponding author), BioTechMed Graz, A-8010 Graz, Austria.
EM iva.klobucar@gmail.com; lidija.hofmann@fh-joanneum.at;
   hansjoerg.habisch@medunigraz.at; margarete.lechleitner@medunigraz.at;
   klobucar.lucija@gmail.com; matias.trbusic@gmail.com;
   gudrun.pregartner@medunigraz.at; andrea.berghold@medunigraz.at;
   tobias.madl@medunigraz.at; sasa.frank@medunigraz.at;
   vesna.degoricija@mef.hr
RI Klobučar, Iva/JHS-6524-2023; Madl, Tobias/B-1682-2012
OI Frank, Sasa/0000-0003-4826-7698; Klobucar, Iva/0000-0002-0640-7149;
   Habisch, Hansjorg/0000-0001-5537-506X
FU Austrian Science Fund (FWF)
FX No Statement Available
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Bagyura Z, 2022, BMC CARDIOVASC DISOR, V22, DOI 10.1186/s12872-021-02451-2
   Blaise BJ, 2021, NAT PROTOC, V16, P4299, DOI 10.1038/s41596-021-00579-1
   Bochi GV, 2016, INFLAMMATION, V39, P916, DOI 10.1007/s10753-016-0325-3
   Borén J, 2020, EUR HEART J, V41, P2313, DOI 10.1093/eurheartj/ehz962
   Camont L, 2013, ARTERIOSCL THROM VAS, V33, P2715, DOI 10.1161/ATVBAHA.113.301468
   Chen SX, 2005, J CARDIOVASC PHARM, V46, P803, DOI 10.1097/01.fjc.0000188162.64642.c7
   Codoñer-Franch P, 2012, NUTR METAB CARDIOVAS, V22, P237, DOI 10.1016/j.numecd.2010.06.002
   Colak E, 2021, J MED BIOCHEM, V40, P1, DOI 10.5937/jomb0-24652
   DEGRAAF J, 1991, ARTERIOSCLER THROMB, V11, P298, DOI 10.1161/01.ATV.11.2.298
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Ginsberg HN, 2021, EUR HEART J, V42, P4791, DOI 10.1093/eurheartj/ehab551
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   JAMES RW, 1988, J LIPID RES, V29, P1557
   Karlsson H, 2015, HANDB EXP PHARMACOL, V224, P207, DOI 10.1007/978-3-319-09665-0_5
   Klobucar I, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms241310681
   Klobucar I, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24032073
   Klobucar I, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10071668
   Kontush A, 2005, ATHEROSCLEROSIS, V182, P277, DOI 10.1016/j.atherosclerosis.2005.03.001
   Kontush A, 2003, ARTERIOSCL THROM VAS, V23, P1881, DOI 10.1161/01.ATV.0000091338.93223.E8
   Kontush A, 1996, FREE RADICAL RES, V24, P135, DOI 10.3109/10715769609088009
   Kontush A, 2007, ARTERIOSCL THROM VAS, V27, P1843, DOI 10.1161/ATVBAHA.107.145672
   Liang M, 2014, J DIABETES, V6, P417, DOI 10.1111/1753-0407.12134
   Liu SX, 2006, ARTERIOSCL THROM VAS, V26, P1156, DOI 10.1161/01.ATV.0000214960.85469.68
   Maher AD, 2008, ANAL CHEM, V80, P7354, DOI 10.1021/ac801053g
   Marsche G, 2009, CIRC RES, V104, P750, DOI 10.1161/CIRCRESAHA.108.193169
   Masenga SK, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24097898
   Miljkovic M, 2018, ANGIOLOGY, V69, P861, DOI 10.1177/0003319718780041
   Monserrat-Mesquida M, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9030236
   Morelli NR, 2018, ARCH ENDOCRIN METAB, V62, P309, DOI 10.20945/2359-3997000000036
   Nobécourt E, 2005, DIABETOLOGIA, V48, P529, DOI 10.1007/s00125-004-1655-5
   Ou HX, 2017, CARDIOVASC TOXICOL, V17, P1, DOI 10.1007/s12012-016-9377-8
   Pang ZQ, 2021, NUCLEIC ACIDS RES, V49, pW388, DOI 10.1093/nar/gkab382
   Piwowar Agnieszka, 2010, Pol Merkur Lekarski, V28, P227
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Rosenson RS, 2011, CLIN CHEM, V57, P392, DOI 10.1373/clinchem.2010.155333
   Schilcher I, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22020719
   Schilcher I, 2019, BBA-MOL CELL BIOL L, P1363, DOI 10.1016/j.bbalip.2019.06.011
   Sebeková K, 2006, MOL NUTR FOOD RES, V50, P858, DOI 10.1002/mnfr.200500170
   Selmeci L, 2006, FREE RADICAL RES, V40, P952, DOI 10.1080/10715760600818789
   Selmeci L, 2011, FREE RADICAL RES, V45, P1115, DOI 10.3109/10715762.2011.602074
   Skvarilova Marcela, 2005, Biomedical Papers (Olomouc), V149, P83
   Soran H, 2015, FRONT PHARMACOL, V6, DOI 10.3389/fphar.2015.00222
   Stadler JT, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12010068
   Stadler JT, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.761170
   Stadler JT, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9030242
   Stadler JT, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21238985
   TRIBBLE DL, 1992, ATHEROSCLEROSIS, V93, P189, DOI 10.1016/0021-9150(92)90255-F
   Tribble DL, 2001, AM J MED, V110, P103, DOI 10.1016/S0002-9343(00)00700-2
   TRIBBLE DL, 1995, J LIPID RES, V36, P662
   TRIBBLE DL, 1994, P NATL ACAD SCI USA, V91, P1183, DOI 10.1073/pnas.91.3.1183
   Venturini D, 2015, NUTR RES, V35, P759, DOI 10.1016/j.nutres.2015.06.013
   WitkoSarsat V, 1996, KIDNEY INT, V49, P1304, DOI 10.1038/ki.1996.186
   World Med Assoc, 2013, JAMA-J AM MED ASSOC, V310, P2191, DOI 10.1001/jama.2013.281053
   Yuan Fang, 2004, Di Yi Jun Yi Da Xue Xue Bao, V24, P1350
   Zhao YL, 2019, EUR J CLIN INVEST, V49, DOI 10.1111/eci.13098
   Zurawska-Plaksej E, 2014, J ENDOCRINOL INVEST, V37, P819, DOI 10.1007/s40618-014-0111-8
NR 57
TC 1
Z9 1
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAR
PY 2024
VL 13
IS 3
AR 339
DI 10.3390/antiox13030339
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA MC9Y5
UT WOS:001191557400001
PM 38539872
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Liu, BY
   Xue, JL
   Zhang, MY
   Wang, MY
   Ma, TT
   Zhao, M
   Gu, QQ
   Qin, SC
AF Liu, Boyan
   Xue, Junli
   Zhang, Mengyu
   Wang, Mingyue
   Ma, Tingting
   Zhao, Min
   Gu, Qianqian
   Qin, Shucun
TI Hydrogen inhalation alleviates nonalcoholic fatty liver disease in
   metabolic syndrome rats
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE molecular hydrogen; metabolic syndrome; nonalcoholic fatty liver
   disease; lipid metabolism
ID RICH WATER; AMERICAN ASSOCIATION; INSULIN-RESISTANCE; CHOLESTEROL
   LEVELS; OXIDATIVE STRESS; GENE-EXPRESSION; PPAR-ALPHA; VITAMIN-E;
   STEATOHEPATITIS; ANTIOXIDANT
AB Hydrogen exhibits therapeutic and preventive effects against various diseases. The present study investigated the potential protective effect and dose-dependent manner of hydrogen inhalation on high fat and fructose diet (HFFD)-induced nonalcoholic fatty liver disease (NAFLD) in Sprague-Dawley rats. Rats were randomly divided into four groups: i) Control group, regular diet/air inhalation; ii) model group, HFFD/air inhalation; iii) low hydrogen group, HFFD/4% hydrogen inhalation; and iv) high hydrogen group, HFFD/67% hydrogen inhalation. After a 10-week experiment, hydrogen inhalation ameliorated weight gain, abdominal fat index, liver index and body mass index of rats fed with HFFD and lowered the total area under the curve in an oral glucose tolerance test. Hydrogen inhalation also ameliorated the increase in liver lipid content and alanine transaminase and aspartate transaminase activities. Liver histopathologic changes evaluated with hematoxylin and eosin as well as Oil Red O staining revealed lower lipid deposition in hydrogen inhalation groups, consistent with the decrease in the expression of the lipid synthesis gene SREBP-1c. The majority of the indicators were affected following treatment with hydrogen in a dose-dependent manner. In conclusion, hydrogen inhalation may play a protective role by influencing the general state, lipid metabolism parameters, liver histology and liver function indicators in the rat model of metabolic syndrome with NAFLD.
C1 [Liu, Boyan; Xue, Junli; Zhang, Mengyu; Wang, Mingyue; Ma, Tingting; Zhao, Min; Gu, Qianqian; Qin, Shucun] Shandong First Med Univ & Shandong Acad Med Sci, Taishan Inst Hydrogen Biomed, Tai An 271000, Shandong, Peoples R China.
   [Liu, Boyan; Xue, Junli; Zhang, Mengyu; Wang, Mingyue; Ma, Tingting; Zhao, Min; Gu, Qianqian; Qin, Shucun] Shandong First Med Univ & Shandong Acad Med Sci, Inst Atherosclerosis, Key Lab Atherosclerosis Univ Shandong Prov, 2 Yingsheng East Rd, Tai An 271000, Shandong, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical
   Sciences; Shandong First Medical University & Shandong Academy of
   Medical Sciences
RP Qin, SC (corresponding author), Shandong First Med Univ & Shandong Acad Med Sci, Inst Atherosclerosis, Key Lab Atherosclerosis Univ Shandong Prov, 2 Yingsheng East Rd, Tai An 271000, Shandong, Peoples R China.
EM scqin@sdfmu.edu.cn
RI Wang, Ming-Yue/GSD-5460-2022; XUE, JUNLI/ABE-8689-2021
FU National Natural Science Foundation of China [81770855]; Taishan
   Scholars Program of Shandong Province [ts201511057]; Academic promotion
   programme of Shandong First Medical University [2019QL010, 2019PT009]
FX The present study was supported by the National Natural Science
   Foundation of China (grant no. 81770855), Taishan Scholars Program of
   Shandong Province (grant no. ts201511057) and the Academic promotion
   programme of Shandong First Medical University (grant nos. 2019QL010 and
   2019PT009).
CR Ahmed MH, 2007, DRUG DISCOV TODAY, V12, P740, DOI 10.1016/j.drudis.2007.07.009
   Aragno M, 2009, FREE RADICAL BIO MED, V47, P1067, DOI 10.1016/j.freeradbiomed.2009.07.016
   Bjelakovic G, 2007, JAMA-J AM MED ASSOC, V297, P842, DOI 10.1001/jama.297.8.842
   Browning JD, 2004, J CLIN INVEST, V114, P147, DOI 10.1172/JCI200422422
   Bugianesi E, 2002, GASTROENTEROLOGY, V123, P134, DOI 10.1053/gast.2002.34168
   Chalasani N, 2012, HEPATOLOGY, V55, P2005, DOI 10.1002/hep.25762
   Chalasani NP, 2017, HEPATOLOGY, V66, p303A
   Chen JB, 2019, MED GAS RES, V9, P115, DOI 10.4103/2045-9912.266985
   Chen O, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-14072-x
   Choi KS, 2018, BRAIN RES BULL, V142, P122, DOI 10.1016/j.brainresbull.2018.07.006
   DOLE M, 1975, SCIENCE, V190, P152, DOI 10.1126/science.1166304
   Echeverría F, 2019, J NUTR BIOCHEM, V63, P35, DOI 10.1016/j.jnutbio.2018.09.012
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Gee PT, 2011, GENES NUTR, V6, P5, DOI 10.1007/s12263-010-0180-z
   Hashimoto M, 2011, MED GAS RES, V1, DOI 10.1186/2045-9912-1-26
   He Y, 2017, REPROD SCI, V24, P324, DOI 10.1177/1933719116655622
   Hernández-Rodas MC, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201700479
   Hickman I, 2007, HEPATOLOGY, V46, P288, DOI 10.1002/hep.21834
   Hossain N, 2016, GASTROENT RES PRACT, V2016, DOI 10.1155/2016/7109270
   Iio A, 2013, MED GAS RES, V3, DOI 10.1186/2045-9912-3-6
   Juurlink DN, 2009, BMJ-BRIT MED J, V339, DOI 10.1136/bmj.b2942
   Kapravelou G, 2015, APPL PHYSIOL NUTR ME, V40, P1242, DOI 10.1139/apnm-2015-0141
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kawai D, 2012, HEPATOLOGY, V56, P912, DOI 10.1002/hep.25782
   Kim D, 2018, CLIN LIVER DIS, V22, P133, DOI 10.1016/j.cld.2017.08.010
   Korovljev D, 2018, IRISH J MED SCI, V187, P85, DOI 10.1007/s11845-017-1638-4
   Li H, 2017, BIOCHEM PHARMACOL, V130, P83, DOI 10.1016/j.bcp.2017.02.003
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   Lonardo A, 2015, DIGEST LIVER DIS, V47, P181, DOI 10.1016/j.dld.2014.09.020
   Marchesini G, 2003, HEPATOLOGY, V37, P917, DOI 10.1053/jhep.2003.50161
   Nakao A, 2010, J CLIN BIOCHEM NUTR, V46, P140, DOI 10.3164/jcbn.09-100
   Nicolson G.L., 2016, Int J Clin Med, V7, P32, DOI [10.4236/ijcm.2016.71005, DOI 10.4236/IJCM.2016.71005]
   Ohsawa I, 2007, NAT MED, V13, P688, DOI 10.1038/nm1577
   Panchal SK, 2011, J CARDIOVASC PHARM, V57, P51, DOI [10.1097/FJC.0b013e3181feb90a, 10.1097/FJC.0b013e31821b1379]
   Panchal SK, 2011, J BIOMED BIOTECHNOL, DOI 10.1155/2011/351982
   Paquette A, 2008, MENOPAUSE, V15, P1169, DOI 10.1097/gme.0b013e31817b8159
   Peng ZJ, 2015, INT J CLIN EXP PATHO, V8, P2680
   Sanders F, 2016, BIOCHEM SOC T, V44, P638, DOI 10.1042/BST20150235
   Sanyal AJ, 2001, GASTROENTEROLOGY, V120, P1183, DOI 10.1053/gast.2001.23256
   Sanyal Arun J, 2015, Trans Am Clin Climatol Assoc, V126, P271
   Sanyal AJ, 2004, CLIN GASTROENTEROL H, V2, P1107, DOI 10.1016/S1542-3565(04)00457-4
   Song GH, 2015, FREE RADICAL BIO MED, V87, P58, DOI 10.1016/j.freeradbiomed.2015.06.018
   Song GH, 2013, J LIPID RES, V54, P1884, DOI 10.1194/jlr.M036640
   Song GH, 2012, ATHEROSCLEROSIS, V221, P55, DOI 10.1016/j.atherosclerosis.2011.11.043
   Tang A, 2015, RADIOLOGY, V274, P416, DOI 10.1148/radiol.14140754
   Tsatsoulis A, 2013, METABOLISM, V62, P622, DOI 10.1016/j.metabol.2012.11.004
   Tu LN, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-05040-6
   Valenzuela R, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020499
   Valenzuela R, 2011, FOOD FUNCT, V2, P644, DOI 10.1039/c1fo10133a
   Wang L, 2018, SHOCK, V50, P308, DOI 10.1097/SHK.0000000000001018
   Wang O, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0118135
   Yetukuri L, 2007, BMC SYST BIOL, V1, DOI 10.1186/1752-0509-1-12
   Younossi ZM, 2015, HEPATOLOGY, V62, p739A, DOI 10.1002/hep.28431
   Younossi ZM, 2011, CLIN GASTROENTEROL H, V9, P524, DOI 10.1016/j.cgh.2011.03.020
   Zhai X, 2017, MOL MED REP, V15, P1305, DOI 10.3892/mmr.2017.6120
   Zhou HC, 2013, J HEART LUNG TRANSPL, V32, P251, DOI 10.1016/j.healun.2012.11.007
   Zong CL, 2012, METABOLISM, V61, P794, DOI 10.1016/j.metabol.2011.10.014
NR 57
TC 20
Z9 20
U1 1
U2 18
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD OCT
PY 2020
VL 22
IS 4
BP 2860
EP 2868
DI 10.3892/mmr.2020.11364
PG 9
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA NW4US
UT WOS:000575004300029
PM 32945408
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Lian, Y
   Yuan, Q
   Wang, GP
   Tang, F
AF Lian Ying
   Yuan Qun
   Wang Gangpu
   Tang Fang
TI Association between sleep quality and metabolic syndrome: A systematic
   review and meta-analysis
SO PSYCHIATRY RESEARCH
LA English
DT Review
DE Sleep quality; Metabolic syndrome; Meta-analysis
ID INSOMNIA SYMPTOMS; OXIDATIVE STRESS; UNITED-STATES; DURATION;
   POPULATION; INFLAMMATION; DISEASES; HEALTH; COHORT; DISTURBANCE
AB Sleep quality has been suggested to play an important role in development of metabolic syndrome (MetS). However, the results have been inconsistent. A systematic review of observational studies aimed to evaluate the association between sleep quality and MetS. A comprehensive search was conducted in PubMed and EMBASE. The pooled odd ratios (ORs) were calculated using random effects models. The construction of funnel plot was used to explore publication bias, with further application of Egger's test. 22 studies were included. The pooled finding showed that overall sleep quality had a significant positive association with MetS (OR 1.37, 95% CI 1.15-1.64), with substantial heterogeneity (I-2 = 62.4%, P < 0.1). Similarly, the complaints of sleep, including difficulty in falling sleep (OR 1.18, 95% CI 1.05-1.33), difficulty in maintaining sleep (OR 1.15, 95% CI 1.02-1.30) and sleep inefficiency (OR 1.40, 95% CI 1.04-1.89) were proved to be associated with the risk of MetS. Our results indicated the overall sleep quality as well as sleep complaints have significant positive associations with MetS. Further studies based on a longitudinal design using validated tools that measure both objective and subjective components of sleep quality are needed to explore the causal relationship between sleep quality and MetS.
C1 [Lian Ying] Shandong Univ, Dept Med Record Management, Qianfoshan Hosp, Jinan, Shandong, Peoples R China.
   [Yuan Qun] Shandong Ctr Dis Control & Prevent, Jinan, Shandong, Peoples R China.
   [Wang Gangpu] Fourth Hosp Jinan City, Dept Gen Surg, Jinan, Shandong, Peoples R China.
   [Tang Fang] Shandong Univ, Ctr Data Sci Hlth & Med, Qianfoshan Hosp, Jinan, Shandong, Peoples R China.
C3 Shandong University; Shandong First Medical University & Shandong
   Academy of Medical Sciences; Shandong First Medical University &
   Shandong Academy of Medical Sciences; Shandong University
RP Tang, F (corresponding author), Shandong Univ, Ctr Data Sci Hlth & Med, Qianfoshan Hosp, Jinan, Shandong, Peoples R China.
EM tangfangsdu@gmail.com
FU Shandong Provincial Key Research and Development Program
   [2016GSF201075]; Shandong Provincial Natural Science Foundation
   [ZR2015HL102]; Shandong Provincial Medical and Health Science and
   Technology Development Project [2016WS0478]
FX This study was supported by Shandong Provincial Key Research and
   Development Program (Grant No. 2016GSF201075), Shandong Provincial
   Natural Science Foundation (Grant No. ZR2015HL102), and Shandong
   Provincial Medical and Health Science and Technology Development Project
   (Grant No. 2016WS0478).
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Akbaraly TN, 2015, AM J GERIAT PSYCHIAT, V23, P818, DOI 10.1016/j.jagp.2014.10.001
   [Anonymous], OPEN ACCESS LIB J
   Ben Kazman J, 2012, ETHNIC DIS, V22, P410
   Brennan AM, 2006, NAT CLIN PRACT ENDOC, V2, P318, DOI 10.1038/ncpendmet0196
   Buysse DJ, 2014, SLEEP, V37, P9, DOI 10.5665/sleep.3298
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1016/0165-1781(89)90047-4
   Cappuccio FP, 2010, DIABETES CARE, V33, P414, DOI 10.2337/dc09-1124
   Castro-Diehl C, 2015, J CLIN ENDOCR METAB, V100, P3149, DOI 10.1210/jc.2015-1198
   Chang JH, 2015, INT J OCCUP MED ENV, V28, P1011, DOI 10.13075/ijomeh.1896.00359
   Chen LJ, 2015, ENDOCR RES, V40, P220, DOI 10.3109/07435800.2015.1020547
   Chen YJ, 2016, PSYCHONEUROENDOCRINO, V74, P342, DOI 10.1016/j.psyneuen.2016.09.027
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   DerSimonian R, 2015, CONTEMP CLIN TRIALS, V45, P139, DOI 10.1016/j.cct.2015.09.002
   Dewald JF, 2010, SLEEP MED REV, V14, P179, DOI 10.1016/j.smrv.2009.10.004
   Egger M, 1997, BMJ-BRIT MED J, V315, P629, DOI 10.1136/bmj.315.7109.629
   Fatima Y, 2016, OBES REV, V17, P1154, DOI 10.1111/obr.12444
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   Godin O, 2017, CHRONOBIOL INT, V34, P1114, DOI 10.1080/07420528.2017.1332071
   Gonzaga NC, 2016, REV NUTR, V29, P377, DOI 10.1590/1678-98652016000300008
   Hall MH, 2012, SLEEP, V35, P783, DOI 10.5665/sleep.1874
   Iftikhar IH, 2015, ANN AM THORAC SOC, V12, P1364, DOI 10.1513/AnnalsATS.201504-190OC
   Ikeda M, 2014, SLEEP BIOL RHYTHMS, V12, P269, DOI 10.1111/sbr.12071
   Irwin MR, 2016, BIOL PSYCHIAT, V80, P40, DOI 10.1016/j.biopsych.2015.05.014
   Jennings JR, 2007, SLEEP, V30, P219, DOI 10.1093/sleep/30.2.219
   Kanagasabai T, 2015, SLEEP, V38, P1905, DOI 10.5665/sleep.5238
   Khansari N, 2009, RECENT PATENTS INFLA, V3, P73, DOI 10.2174/187221309787158371
   Kielbasa G, 2016, ADV MED SCI-POLAND, V61, P261, DOI 10.1016/j.advms.2016.03.005
   Krueger PM, 2009, AM J EPIDEMIOL, V169, P1052, DOI 10.1093/aje/kwp023
   Kruisbrink M, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2017-018585
   Krystal AD, 2008, SLEEP MED, V9, pS10, DOI 10.1016/S1389-9457(08)70011-X
   Lajoie P, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2014-007327
   Lee J, 2013, TOHOKU J EXP MED, V231, P281, DOI 10.1620/tjem.231.281
   Leineweber C, 2003, SLEEP MED, V4, P531, DOI 10.1016/S1389-9457(03)00160-6
   Li R, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-2870-y
   Lin SC, 2016, SLEEP, V39, P1261, DOI 10.5665/sleep.5848
   Lo K, 2018, J CLIN HYPERTENS, V20, P592, DOI 10.1111/jch.13220
   Massar SAA, 2017, PSYCHONEUROENDOCRINO, V81, P151, DOI 10.1016/j.psyneuen.2017.04.013
   Mesas AE, 2014, DIABETES-METAB RES, V30, P222, DOI 10.1002/dmrr.2480
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Mollayeva T, 2016, SLEEP MED REV, V25, P52, DOI 10.1016/j.smrv.2015.01.009
   Motivala SJ, 2009, PSYCHONEUROENDOCRINO, V34, P540, DOI 10.1016/j.psyneuen.2008.10.016
   Okubo N, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-562
   Pan WH, 2014, SLEEP MED REV, V18, P283, DOI 10.1016/j.smrv.2013.07.003
   Pilcher JJ, 1997, J PSYCHOSOM RES, V42, P583, DOI 10.1016/S0022-3999(97)00004-4
   Pulido-Arjona L, 2018, ITAL J PEDIATR, V44, DOI 10.1186/s13052-018-0451-7
   Rahe C, 2015, SLEEP MED, V16, P1225, DOI 10.1016/j.sleep.2015.05.023
   Rao DP, 2016, INT J BEHAV NUTR PHY, V13, DOI 10.1186/s12966-016-0350-5
   Salo P, 2012, SLEEP MED, V13, P278, DOI 10.1016/j.sleep.2011.06.022
   Sedov ID, 2018, SLEEP MED REV, V38, P168, DOI 10.1016/j.smrv.2017.06.005
   Shankar A, 2008, AM J EPIDEMIOL, V168, P1367, DOI 10.1093/aje/kwn281
   Stamatakis KA, 2010, CHEST, V137, P95, DOI 10.1378/chest.09-0791
   Troxel WM, 2010, SLEEP, V33, P1633, DOI 10.1093/sleep/33.12.1633
   Tsai HJ, 2015, PSYCHIAT RES, V230, P892, DOI 10.1016/j.psychres.2015.11.030
   van der Berg JD, 2016, DIABETOLOGIA, V59, P709, DOI 10.1007/s00125-015-3861-8
   Wallace BC, 2009, BMC MED RES METHODOL, V9, DOI 10.1186/1471-2288-9-80
   Wang SB, 2017, PSYCHIAT RES, V257, P212, DOI 10.1016/j.psychres.2017.07.036
   Wang Y, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-11431-6
   Ward AMV, 2004, METABOLISM, V53, P720, DOI 10.1016/j.metabol.2004.01.008
   Werner KB, 2016, PSYCHIAT RES, V240, P234, DOI 10.1016/j.psychres.2016.04.039
   Xi B, 2014, SLEEP MED REV, V18, P293, DOI 10.1016/j.smrv.2013.06.001
   Yannakoulia M, 2017, SLEEP MED, V34, P242, DOI 10.1016/j.sleep.2017.01.023
   Yoo H, 2013, J OCCUP ENVIRON MED, V55, P111, DOI 10.1097/JOM.0b013e31826e294c
   Zohal M, 2017, DIABETES METAB SYND, V11, pS377, DOI 10.1016/j.dsx.2017.03.020
NR 64
TC 85
Z9 91
U1 1
U2 23
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD APR
PY 2019
VL 274
BP 66
EP 74
DI 10.1016/j.psychres.2019.01.096
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HU1VG
UT WOS:000465059300011
PM 30780064
DA 2025-06-11
ER

PT J
AU Gan, YL
   Fu, JY
   Lai, OM
   Chew, BH
   Yuen, KH
   Teng, KT
   Nesaretnam, K
   Selvaduray, KR
   Meganathan, P
AF Gan, Yee-Lin
   Fu, Ju-Yen
   Lai, Oi-Ming
   Chew, Boon-How
   Yuen, Kah-Hay
   Teng, Kim-Tiu
   Nesaretnam, Kalanithi
   Selvaduray, Kanga Rani
   Meganathan, Puvaneswari
TI Effect of palm-based tocotrienols and tocopherol mixture supplementation
   on platelet aggregation in subjects with metabolic syndrome: a
   randomised controlled trial
SO SCIENTIFIC REPORTS
LA English
DT Article
ID VITAMIN-E SUPPLEMENTATION; ALPHA-TOCOPHEROL; DIABETIC-PATIENTS;
   CHOLESTEROL; MECHANISMS; PARAMETERS; ADHESION; THERAPY; STRESS; HUMANS
AB Tocotrienols, the unsaturated form of vitamin E, were reported to modulate platelet aggregation and thrombotic mechanisms in pre-clinical studies. Using a Food and Drug Administration (FDA)-approved cartridge-based measurement system, a randomised, double-blind, crossover and placebo-controlled trial involving 32 metabolic syndrome adults was conducted to investigate the effect of palm-based tocotrienols and tocopherol (PTT) mixture supplementation on platelet aggregation reactivity. The participants were supplemented with 200 mg (69% tocotrienols and 31% alpha-tocopherol) twice daily of PTT mixture or placebo capsules for 14 days in a random order. After 14 days, each intervention was accompanied by a postprandial study, in which participants consumed 200 mg PTT mixture or placebo capsule after a meal. Blood samples were collected on day 0, day 14 and during postprandial for the measurement of platelet aggregation reactivity. Subjects went through a 15-day washout period before commencement of subsequent intervention. Fasting platelet aggregation reactivity stimulated with adenosine diphosphate (ADP) did not show substantial changes after supplementation with PTT mixture compared to placebo (p = 0.393). Concomitantly, changes in postprandial platelet aggregation reactivity remained similar between PTT mixture and placebo interventions (p = 0.408). The results of this study highlight the lack of inhibitory effect on platelet aggregation after short-term supplementation of PTT mixture in participants with metabolic syndrome.
C1 [Gan, Yee-Lin; Lai, Oi-Ming] Univ Putra Malaysia, Dept Bioproc Technol, Fac Biotechnol & Biomol Sci, Serdang, Malaysia.
   [Gan, Yee-Lin; Fu, Ju-Yen; Teng, Kim-Tiu; Nesaretnam, Kalanithi; Selvaduray, Kanga Rani; Meganathan, Puvaneswari] Persiaran Inst, Nutr Unit, Prod Dev & Advisory Serv Div, Malaysian Palm Oil Board, 6 Bandar Baru Bangi, Kajang, Selangor, Malaysia.
   [Lai, Oi-Ming] Univ Putra Malaysia, Inst Biosci, Serdang, Malaysia.
   [Chew, Boon-How] Univ Putra Malaysia, Dept Family Med, Fac Med & Hlth Sci, Serdang, Malaysia.
   [Yuen, Kah-Hay] Univ Sains Malaysia, Sch Pharmaceut Sci, George Town, Malaysia.
C3 Universiti Putra Malaysia; Malaysian Palm Oil Board; Universiti Putra
   Malaysia; Universiti Putra Malaysia; Universiti Sains Malaysia
RP Fu, JY (corresponding author), Persiaran Inst, Nutr Unit, Prod Dev & Advisory Serv Div, Malaysian Palm Oil Board, 6 Bandar Baru Bangi, Kajang, Selangor, Malaysia.
EM fujuyen@gmail.com
RI Fu, Ju/AAX-4041-2020; Yuen, Kah/F-9059-2010; Chew, Boon How/B-2385-2010
OI Kim Tiu, Teng/0000-0003-1383-8913; Fu, Ju-Yen/0000-0002-4398-4471;
   Selvaduray, Kanga Rani/0000-0003-1832-3118; Chew, Boon
   How/0000-0002-8627-6248
CR Alessi MC, 2008, THROMB HAEMOSTASIS, V99, P995, DOI 10.1160/TH07-11-0682
   Alessi MC, 2006, ARTERIOSCL THROM VAS, V26, P2200, DOI 10.1161/01.ATV.0000242905.41404.68
   Bardhan J, 2011, CURR PHARM DESIGN, V17, P2196, DOI 10.2174/138161211796957472
   Beckett R.P., 2008, Preparation of substituted imidazoheterocycles, particularly 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazines and 6,7,8,9- tetrahydroimidazo[1,5-a][1,4]diazepines, as cannabinoid receptor modulators, P1
   Binkley NC, 2000, AM J CLIN NUTR, V72, P1523
   Budin SB, 2009, CLINICS, V64, P235, DOI 10.1590/S1807-59322009000300015
   Che HL, 2015, INT J ANAL CHEM, V2015, DOI 10.1155/2015/357609
   COLETTE C, 1988, AM J CLIN NUTR, V47, P256, DOI 10.1093/ajcn/47.2.256
   Dyszkiewicz-Korpanty AM, 2005, CLIN APPL THROMB-HEM, V11, P25, DOI 10.1177/107602960501100103
   Freedman JE, 1996, CIRCULATION, V94, P2434, DOI 10.1161/01.CIR.94.10.2434
   Furman Mark I, 2003, Am Heart J, V145, pe6, DOI 10.1067/mhj.2003.116
   Gawaz M., 2001, BLOOD PLATELETS PHYS, P4
   GISINGER C, 1988, DIABETES, V37, P1260, DOI 10.2337/diabetes.37.9.1260
   GOH SH, 1985, J AM OIL CHEM SOC, V62, P237, DOI 10.1007/BF02541384
   Gopalan Y, 2014, STROKE, V45, P1422, DOI 10.1161/STROKEAHA.113.004449
   Harrison P, 2005, BLOOD REV, V19, P111, DOI 10.1016/j.blre.2004.05.002
   Harrison P, 2007, THROMB RES, V120, P323, DOI 10.1016/j.thromres.2006.11.012
   HAYES KC, 1993, P SOC EXP BIOL MED, V202, P353, DOI 10.3181/00379727-202-43546
   Jang MJ, 2009, ARTERIOSCL THROM VAS, V29, P311, DOI 10.1161/ATVBAHA.109.184085
   Kim JE, 2011, THROMB RES, V127, P435, DOI 10.1016/j.thromres.2011.01.007
   KOBA K, 1992, BIOSCI BIOTECH BIOCH, V56, P1420, DOI 10.1271/bbb.56.1420
   Koren-Morag N, 2005, STROKE, V36, P1366, DOI 10.1161/01.STR.0000169945.75911.33
   Kreutz RP, 2013, PLATELETS, V24, P145, DOI 10.3109/09537104.2012.661107
   Lange RA, 2004, NEW ENGL J MED, V350, P277, DOI 10.1056/NEJMe038191
   Lau DCW, 2006, CAN J CARDIOL, V22, p85B, DOI 10.1016/S0828-282X(06)70992-8
   Lev EI, 2010, J AM COLL CARDIOL, V55, P114, DOI 10.1016/j.jacc.2009.08.039
   Li ZY, 2010, ARTERIOSCL THROM VAS, V30, P2341, DOI 10.1161/ATVBAHA.110.207522
   Liu ML, 2003, AM J CLIN NUTR, V77, P700, DOI 10.1093/ajcn/77.3.700
   Mensink RP, 1999, AM J CLIN NUTR, V69, P213
   Ministry of Health Malaysia, 2009, CLIM CHANG ITS IMP J, P36
   Morange PE, 2013, THROMB HAEMOSTASIS, V110, P669, DOI 10.1160/TH13-01-0075
   Nicholson NS, 1998, AM HEART J, V135, pS170, DOI 10.1016/S0002-8703(98)70245-5
   Nielsen HL, 2008, THROMB RES, V123, P267, DOI 10.1016/j.thromres.2008.03.023
   Pignatelli P, 1999, ARTERIOSCL THROM VAS, V19, P2542, DOI 10.1161/01.ATV.19.10.2542
   QURESHI AA, 1991, AM J CLIN NUTR, V53, pS1021, DOI 10.1093/ajcn/53.4.1021S
   QURESHI AA, 1995, LIPIDS, V30, P1171, DOI 10.1007/BF02536620
   Qureshi AA, 2001, ATHEROSCLEROSIS, V156, P39, DOI 10.1016/S0021-9150(00)00612-2
   Qureshi AA, 2001, J NUTR, V131, P223, DOI 10.1093/jn/131.2.223
   Qureshi AA, 1997, J NUTR BIOCHEM, V8, P290, DOI 10.1016/S0955-2863(97)89667-2
   QURESHI AA, 1991, AM J CLIN NUTR, V53, pS1042, DOI 10.1093/ajcn/53.4.1042S
   Qureshi AA, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-58
   Remijn JA, 2002, ARTERIOSCL THROM VAS, V22, P686, DOI 10.1161/01.ATV.0000012805.49079.23
   Saw J, 2005, CONTEMP CARDIOL, P335
   Serebruany VL, 2008, J THROMB THROMBOLYS, V25, P207, DOI 10.1007/s11239-007-0047-3
   Shibata A, 2016, J AGR FOOD CHEM, V64, P5361, DOI 10.1021/acs.jafc.6b02228
   Singh I, 2007, ASIA PAC J CLIN NUTR, V16, P422
   STEINER M, 1983, THROMB HAEMOSTASIS, V49, P73
   Steinhubl SR, 2007, PLATELETS, 2ND EDITION, P509, DOI 10.1016/B978-012369367-9/50789-8
   Sweeny JM, 2009, NAT REV CARDIOL, V6, P273, DOI 10.1038/nrcardio.2009.10
   TOMEO AC, 1995, LIPIDS, V30, P1179, DOI 10.1007/BF02536621
   von Känel R, 2003, CLIN CARDIOL, V26, P164, DOI 10.1002/clc.4960260403
   WAHLQVIST ML, 1992, NUTR RES, V12, pS181, DOI 10.1016/S0271-5317(05)80463-4
   WATKINS T, 1993, LIPIDS, V28, P1113, DOI 10.1007/BF02537079
   Williams JC, 1997, INT J EXP PATHOL, V78, P259, DOI 10.1046/j.1365-2613.1997.260359.x
   Yuen KH, 2011, FUNCT FOODS HEALTH D, V1, P106
NR 55
TC 7
Z9 7
U1 0
U2 8
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 14
PY 2017
VL 7
AR 11542
DI 10.1038/s41598-017-11813-w
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FG9DM
UT WOS:000410739000040
PM 28912593
OA Green Accepted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Semenova, N
   Garashchenko, N
   Kolesnikov, S
   Darenskaya, M
   Kolesnikova, L
AF Semenova, Natalya
   Garashchenko, Nadezhda
   Kolesnikov, Sergey
   Darenskaya, Marina
   Kolesnikova, Liubov
TI Gut Microbiome Interactions with Oxidative Stress: Mechanisms and
   Consequences for Health
SO PATHOPHYSIOLOGY
LA English
DT Review
DE gut microbiome; oxidative stress; food supplements; TMAO; melatonin;
   mitochondria
ID INFLAMMATORY-BOWEL-DISEASE; ADOLESCENTS; DEFINITION; AUTOPHAGY; SYSTEM;
   DAMAGE
AB Understanding how gut flora interacts with oxidative stress has been the subject of significant research in recent years. There is much evidence demonstrating the existence of the microbiome-oxidative stress interaction. However, the biochemical basis of this interaction is still unclear. In this narrative review, possible pathways of the gut microbiota and oxidative stress interaction are presented, among which genetic underpinnings play an important role. Trimethylamine-N-oxide, mitochondria, short-chain fatty acids, and melatonin also appear to play roles. Moreover, the relationship between oxidative stress and the gut microbiome in obesity, metabolic syndrome, chronic ethanol consumption, dietary supplements, and medications is considered. An investigation of the correlation between bacterial community features and OS parameter changes under normal and pathological conditions might provide information for the determination of new research methods. Furthermore, such research could contribute to establishing a foundation for determining the linkers in the microbiome-OS association.
C1 [Semenova, Natalya; Garashchenko, Nadezhda; Kolesnikov, Sergey; Darenskaya, Marina; Kolesnikova, Liubov] Sci Ctr Family Hlth & Human Reprod Problems, Irkutsk 664003, Russia.
C3 Irkutsk Science Centre of the Russian Academy of Sciences; Scientific
   Centre for Family Health & Human Reproduction Problems
RP Semenova, N (corresponding author), Sci Ctr Family Hlth & Human Reprod Problems, Irkutsk 664003, Russia.
EM natkor_84@mail.ru; nadzelin@mail.ru; sikolesnikov2012@gmail.com;
   marina_darenskaya@inbox.ru; kolesnikova20121@mail.ru
RI Semenova, Natalya/J-7025-2016; Darenskaya, Marina A./O-4490-2015;
   Kolesnikov, Sergey/M-4020-2016
OI Darenskaya, Marina A./0000-0003-3255-2013; Semenova,
   Natalya/0000-0002-6512-1335; Kolesnikov, Sergey/0000-0003-2124-6328
FX This research received no external funding.
CR Alemany-Cosme E, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10010064
   Alfadda AA, 2012, J BIOMED BIOTECHNOL, DOI 10.1155/2012/936486
   Aljeradat B., 2024, Pathophysiology
   Almeida A, 2019, NATURE, V568, P499, DOI 10.1038/s41586-019-0965-1
   Annese V, 2020, PHARMACOL RES, V159, DOI 10.1016/j.phrs.2020.104892
   Balmus IM, 2016, SAUDI J GASTROENTERO, V22, P3, DOI 10.4103/1319-3767.173753
   Barko PC, 2018, J VET INTERN MED, V32, P9, DOI 10.1111/jvim.14875
   Bruner LP, 2023, PRIMARY CARE, V50, P411, DOI 10.1016/j.pop.2023.03.009
   Brunt VE, 2019, J PHYSIOL-LONDON, V597, P2361, DOI 10.1113/JP277336
   Bubenik GA, 2001, BIOL SIGNAL RECEPT, V10, P350
   Chen CQ, 2011, WORLD J GASTROENTERO, V17, P3888, DOI 10.3748/wjg.v17.i34.3888
   Chen J, 2021, J AGR FOOD CHEM, V69, P14176, DOI 10.1021/acs.jafc.1c05596
   Cipolla-Neto J, 2018, ENDOCR REV, V39, P990, DOI 10.1210/er.2018-00084
   Cobb CA, 2015, NEUROBIOL DIS, V84, P4, DOI 10.1016/j.nbd.2015.04.020
   Darenskaya MA, 2023, B EXP BIOL MED+, V174, P601, DOI 10.1007/s10517-023-05754-w
   Darenskaya M, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms241512378
   Darenskaya MA, 2022, INT J BIOMED, V12, P344, DOI 10.21103/Article12(3)_RA3
   Darenskaya MA, 2018, INT J BIOMED, V8, P37, DOI 10.21103/Article8(1)_OA5
   Day-Walsh P, 2021, EUR J NUTR, V60, P3987, DOI 10.1007/s00394-021-02572-6
   Di Lorenzo C, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010273
   Duncan SH, 2002, APPL ENVIRON MICROB, V68, P5186, DOI 10.1128/AEM.68.10.5186-5190.2002
   Dunnill CJ, 2017, ONCOGENE, V36, P2515, DOI 10.1038/onc.2016.401
   Filomeni G, 2015, CELL DEATH DIFFER, V22, P377, DOI 10.1038/cdd.2014.150
   Forman HJ, 2021, NAT REV DRUG DISCOV, V20, P689, DOI 10.1038/s41573-021-00233-1
   Gao T, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/9981480
   Gao YF, 2023, J HAZARD MATER, V457, DOI 10.1016/j.jhazmat.2023.131741
   Ghosh TS, 2020, ELIFE, V9, DOI 10.7554/eLife.50240
   Ghosh TS, 2022, NATURE AGING, V2, P1054, DOI 10.1038/s43587-022-00306-9
   Ghosh TS, 2022, NAT REV GASTRO HEPAT, V19, P565, DOI 10.1038/s41575-022-00605-x
   Hao LH, 2021, APPL MICROBIOL BIOT, V105, P1657, DOI 10.1007/s00253-021-11111-6
   He JJ, 2022, NUTRIENTS, V14, DOI 10.3390/nu14061276
   Hendrix J, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9111166
   Hu CJ, 2021, FRONT CELL INFECT MI, V11, DOI 10.3389/fcimb.2021.671347
   Iesanu MI, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11112244
   Jurcau A, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222111847
   Kansakar U, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1148166
   Kedia S, 2023, JGH OPEN, V7, P337, DOI 10.1002/jgh3.12902
   Kimura I, 2020, PHYSIOL REV, V100, P171, DOI 10.1152/physrev.00041.2018
   Klimenko ES, 2022, B EXP BIOL MED+, V173, P628, DOI 10.1007/s10517-022-05601-4
   Konopelski P, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23031222
   Kruidenier L, 2003, J PATHOL, V201, P28, DOI 10.1002/path.1409
   Ley RE, 2008, SCIENCE, V320, P1647, DOI 10.1126/science.1155725
   Li HL, 2022, ACTA PHARMACOL SIN, V43, P919, DOI 10.1038/s41401-021-00726-0
   Li L, 2019, AGING-US, V11, P9348, DOI 10.18632/aging.102376
   Li TJ, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00350
   Liu XL, 2021, FOOD FUNCT, V12, P12142, DOI [10.1039/d1fo01349a, 10.1039/D1FO01349A]
   Luo ZS, 2024, J PHYSIOL BIOCHEM, V80, P67, DOI 10.1007/s13105-023-00984-y
   Magliocca G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23105354
   Marino A, 2021, FREE RADICAL BIO MED, V166, P238, DOI 10.1016/j.freeradbiomed.2021.02.047
   Mei LH, 2021, NUTRIENTS, V13, DOI 10.3390/nu13113891
   Mei QX, 2021, ACTA PHARMACOL SIN, V42, P942, DOI 10.1038/s41401-020-00581-5
   Merecz-Sadowska A, 2023, NUTRIENTS, V15, DOI 10.3390/nu15133016
   Miyamoto J, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17040450
   Moreno-Pérez D, 2018, NUTRIENTS, V10, DOI 10.3390/nu10030337
   Nikitina O. A., 2023, Cell and Tissue Biology, V17, P16, DOI 10.1134/S1990519X2301011X
   Ohira H., Alteration of Oxidative-Stress and Related Marker Levels in Mouse Colonic Tissues and Fecal Microbiota Structures with Chronic Ethanol Administration: Implications for the Pathogenesis of Ethanol-Related Colorectal Cancer
   Omar NN, 2022, MOLECULES, V27, DOI 10.3390/molecules27134069
   Pan SP, 2022, FRONT CELL INFECT MI, V12, DOI 10.3389/fcimb.2022.1022879
   Paul P, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.906243
   Peters BA, 2022, INT J WOMENS HEALTH, V14, P1059, DOI 10.2147/IJWH.S340491
   Rode J, 2021, NEUROPSYCHOBIOLOGY, V80, P253, DOI 10.1159/000510886
   Romano KA, 2015, MBIO, V6, DOI 10.1128/mBio.02481-14
   Rose S, 2018, TRANSL PSYCHIAT, V8, DOI 10.1038/s41398-017-0089-z
   Rothschild D, 2018, NATURE, V555, P210, DOI 10.1038/nature25973
   Semenova NV, 2021, B EXP BIOL MED+, V171, P384, DOI 10.1007/s10517-021-05233-0
   Semenova N V, 2019, Zh Nevrol Psikhiatr Im S S Korsakova, V119, P7, DOI 10.17116/jnevro20191190717
   Shanahan F, 2021, GASTROENTEROLOGY, V160, P483, DOI 10.1053/j.gastro.2020.09.057
   Shandilya S, 2022, J ADV RES, V38, P223, DOI 10.1016/j.jare.2021.09.005
   Shantir' I. I., 2019, Ekologiya Cheloveka / Human Ecology, P23, DOI 10.33396/1728-0869-2019-6-23-29
   Sharon G, 2016, CELL, V167, P915, DOI 10.1016/j.cell.2016.10.027
   Shi CX, 2022, BIOCHEM BIOPH RES CO, V594, P1, DOI 10.1016/j.bbrc.2022.01.060
   Sies H, 2015, REDOX BIOL, V4, P180, DOI 10.1016/j.redox.2015.01.002
   Sorboni SG, 2022, CLIN MICROBIOL REV, V35, DOI 10.1128/CMR.00338-20
   Subramaniam S, 2018, BRIT J PHARMACOL, V175, P1344, DOI 10.1111/bph.13959
   Sun YQ, 2024, FRONT MICROBIOL, V15, DOI 10.3389/fmicb.2024.1328324
   Tang JL, 2022, FRONT MICROBIOL, V13, DOI 10.3389/fmicb.2022.1005842
   Tang Y, 2011, CELL DEATH DIFFER, V18, P602, DOI 10.1038/cdd.2010.117
   Tsuruya A, 2016, SCI REP-UK, V6, DOI 10.1038/srep27923
   Ünal ED, 2022, TURK J MED SCI, V52, P1917, DOI 10.55730/1300-0144.5539
   Vatner SF, 2020, AGEING RES REV, V64, DOI 10.1016/j.arr.2020.101194
   Verma AK, 2023, REJUV RES, V26, P229, DOI 10.1089/rej.2023.0047
   Wan F., Front. Cell. Infect. Microbiol
   Wang FG, 2020, MEDIAT INFLAMM, V2020, DOI 10.1155/2020/5821428
   Wang JY, 2023, FRONT CELL INFECT MI, V13, DOI 10.3389/fcimb.2023.1196967
   Wang L, 2022, J AGR FOOD CHEM, V70, P1163, DOI 10.1021/acs.jafc.1c07711
   Wang T, 2022, SAUDI J GASTROENTERO, V28, P209, DOI 10.4103/sjg.sjg_110_21
   Wang Y, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11112287
   Wei YH, 2002, EXP BIOL MED, V227, P671, DOI 10.1177/153537020222700901
   Wu BY, 2022, ECOTOX ENVIRON SAFE, V244, DOI 10.1016/j.ecoenv.2022.114037
   Xu FZ, 2020, MICROBIOME, V8, DOI 10.1186/s40168-020-00923-9
   Xu S, 2023, BMC MED, V21, DOI 10.1186/s12916-023-02878-8
   Yang C, 2019, FOOD RES INT, V116, P1202, DOI 10.1016/j.foodres.2018.10.003
   Yasmin F, 2021, GEN COMP ENDOCR, V303, DOI 10.1016/j.ygcen.2020.113693
   Zhang H, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11091727
   Zhang H, 2021, J HAZARD MATER, V407, DOI 10.1016/j.jhazmat.2020.124489
   Zhang KM, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/9441896
   Zhao JC, 2018, FOOD FUNCT, V9, P917, DOI [10.1039/c7fo01574g, 10.1039/C7FO01574G]
   Zhao WD, 2024, PATHOPHYSIOLOGY-BASE, V31, P68, DOI 10.3390/pathophysiology31010006
   Zheng F, 2021, J FOOD BIOCHEM, V45, DOI 10.1111/jfbc.13943
   Zhu T, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/8868941
   Zhu YY, 2022, J AGR FOOD CHEM, V70, P3818, DOI 10.1021/acs.jafc.2c00117
   Zou YF, 2023, FRONT IMMUNOL, V14, DOI 10.3389/fimmu.2023.1159291
   Zou YQ, 2024, MED RES REV, V44, P539, DOI 10.1002/med.21989
NR 103
TC 7
Z9 7
U1 2
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 0928-4680
EI 1873-149X
J9 PATHOPHYSIOLOGY-BASE
JI Pathophysiology
PD SEP
PY 2024
VL 31
IS 3
BP 309
EP 330
DI 10.3390/pathophysiology31030023
PG 22
WC Pathology
WE Emerging Sources Citation Index (ESCI)
SC Pathology
GA H4O4X
UT WOS:001323250000001
PM 39051221
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wang, MJ
   Liu, JL
   Zhang, Z
   Zhang, HX
   Wang, N
   Chen, X
   Han, XM
   Lu, Q
   Chi, SS
AF Wang, Mengjun
   Liu, Junliang
   Zhang, Zhao
   Zhang, Haixiong
   Wang, Ning
   Chen, Xi
   Han, Xuemei
   Lu, Qian
   Chi, Shanshan
TI Effects of Dietary Intervention on Inflammatory Markers in Metabolic
   Syndrome: A Systematic Review and Meta-Analysis
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE diets; inflammatory markers; IL-6; metabolic syndrome; meta-analysis
ID ENDOTHELIAL FUNCTION; OXIDATIVE STRESS; HEART-DISEASE; CEREAL FOODS;
   RISK-FACTORS; OBESITY; ADULTS; INTERLEUKIN-6; CARBOHYDRATE; RESTRICTION
AB BackgroundDietary interventions may modulate inflammatory indicators, but the correlations between dietary intervention and inflammatory markers in metabolic syndrome (MetS) settings remain opaque. ObjectiveTo evaluate the effects of dietary intervention on interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP) in patients with MetS by systematic review and meta-analysis. MethodsDatabases, including PubMed, Embase, Cochrane Library, Scopus, and Google scholar, were searched from June 2011 to June 2021 for relevant available articles. Standardized mean difference (SMD) was generated as effect size by meta-analysis for continuous variants, including IL-1 beta, IL-6, TNF-alpha, and CRP levels. Then, according to study characteristics by dietary patterns of the intervention, subgroup analyses were performed. ResultsFinally, 13 studies comprising a total of 1,101 participants were included for the meta-analysis. IL-6 levels in dietary patients were significantly lower than controls (SMD = -0.30, 95% CI = -0.55, 0.04, p = 0.02, I-2 = 64%). However, IL-1 beta, TNF-alpha, and CRP levels did not change significantly compared with the control group. Sensitivity analyses further yielded similar results. ConclusionsDietary intervention may help decrease IL-6 rather than IL-1 beta, TNF-alpha, or CRP levels in patients with MetS.
C1 [Wang, Mengjun; Wang, Ning] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Endocrinol, Xian, Peoples R China.
   [Liu, Junliang; Zhang, Zhao; Zhang, Haixiong; Han, Xuemei; Lu, Qian; Chi, Shanshan] 521 Hosp Norinco Grp, Dept Endocrinol, Xian, Peoples R China.
   [Chen, Xi] Zhejiang Univ, Med Coll, Sch Publ Hlth, Dept Epidemiol & Stat, Hangzhou, Peoples R China.
C3 Xi'an Jiaotong University; Zhejiang University
RP Zhang, Z (corresponding author), 521 Hosp Norinco Grp, Dept Endocrinol, Xian, Peoples R China.
EM wmj19871112521@163.com
RI Han, Xuemei/JGE-2116-2023; zhao, sheng/JWO-6127-2024; Wang,
   Ning/AFI-3287-2022
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Alicka M, 2018, STEM CELLS INT, V2018, DOI 10.1155/2018/4274361
   Athyros VG, 2010, CURR MED RES OPIN, V26, P713, DOI 10.1185/03007991003590597
   Basu A, 2011, NUTR RES, V31, P190, DOI 10.1016/j.nutres.2011.02.003
   Besedovsky HO, 2014, CURR PHARM DESIGN, V20, P4733, DOI 10.2174/1381612820666140130204401
   Blesso CN, 2013, J CLIN LIPIDOL, V7, P463, DOI 10.1016/j.jacl.2013.03.008
   Simao TNC, 2013, BRIT J NUTR, V110, P1885, DOI 10.1017/S0007114513001207
   Dewell A, 2011, J NUTR, V141, P2166, DOI 10.3945/jn.111.142240
   Giacco R, 2013, CLIN NUTR, V32, P941, DOI 10.1016/j.clnu.2013.01.016
   Gulati S, 2014, NUTRITION, V30, P192, DOI 10.1016/j.nut.2013.08.005
   HEINRICH PC, 1990, BIOCHEM J, V265, P621, DOI 10.1042/bj2650621
   Higgins J, Cochrane Handbook for Systematic Reviews of Interventions Internet
   Jeong HS, 2014, PHYTOTHER RES, V28, P1492, DOI 10.1002/ptr.5154
   Julibert A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081901
   Larsen CM, 2007, NEW ENGL J MED, V356, P1517, DOI 10.1056/NEJMoa065213
   Lopez-Legarrea P, 2014, NUTRITION, V30, P424, DOI 10.1016/j.nut.2013.09.009
   Lumeng CN, 2011, J CLIN INVEST, V121, P2111, DOI 10.1172/JCI57132
   Marques-Vidal P, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051768
   Martins AD, 2019, WORLD J MENS HEALTH, V37, P113, DOI 10.5534/wjmh.180055
   Michels KB, 2005, NUTR RES REV, V18, P241, DOI 10.1079/NRR2005107
   Mirjafari H, 2014, ARTHRITIS RHEUMATOL, V66, pS80, DOI 10.1002/art.38470
   Mitch WE, 2005, KIDNEY INT, V67, pS133, DOI 10.1111/j.1523-1755.2005.09430.x
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Namazi N, 2018, HORM METAB RES, V50, P345, DOI 10.1055/a-0596-8204
   O'Neil A, 2015, BRIT J NUTR, V114, P2074, DOI 10.1017/S0007114515003815
   Popko K, 2010, EUR J MED RES, V15, P120
   Roager HM, 2019, GUT, V68, P83, DOI 10.1136/gutjnl-2017-314786
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Santesso N, 2012, EUR J CLIN NUTR, V66, P780, DOI 10.1038/ejcn.2012.37
   Sitzmann BD, 2014, AGE, V36, P183, DOI 10.1007/s11357-013-9563-6
   Smitka Kvido, 2015, Prague Med Rep, V116, P87, DOI 10.14712/23362936.2015.49
   Stern L, 2004, ANN INTERN MED, V140, P778, DOI 10.7326/0003-4819-140-10-200405180-00007
   Tardivo AP, 2015, CLIMACTERIC, V18, P290, DOI 10.3109/13697137.2014.981521
   Tousoulis D, 2014, ATHEROSCLEROSIS, V232, P10, DOI 10.1016/j.atherosclerosis.2013.10.014
   Urizar AI, 2016, J INTERF CYTOK RES, V36, P20, DOI 10.1089/jir.2014.0199
   Vetrani C, 2016, NUTRITION, V32, P217, DOI 10.1016/j.nut.2015.08.006
   Vissers LET, 2016, ATHEROSCLEROSIS, V253, P164, DOI 10.1016/j.atherosclerosis.2016.07.929
   Yadav R, 2019, TRANSL BEHAV MED, V9, P594, DOI 10.1093/tbm/iby060
   Yudkin JS, 2000, ATHEROSCLEROSIS, V148, P209, DOI 10.1016/S0021-9150(99)00463-3
   Zhao G, 2014, PLOS COMPUT BIOL, V10, DOI 10.1371/journal.pcbi.1003798
NR 41
TC 9
Z9 9
U1 0
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD MAR 31
PY 2022
VL 9
AR 846591
DI 10.3389/fnut.2022.846591
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 0V8GV
UT WOS:000788578900001
PM 35433780
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mastrodonato, M
   Calamita, G
   Rossi, R
   Mentino, D
   Bonfrate, L
   Portincasa, P
   Ferri, D
   Liquori, GE
AF Mastrodonato, Maria
   Calamita, Giuseppe
   Rossi, Roberta
   Mentino, Donatella
   Bonfrate, Leonilde
   Portincasa, Piero
   Ferri, Domenico
   Liquori, Giuseppa E.
TI Altered distribution of caveolin-1 in early liver steatosis
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE Choline-deficient diet; fatty liver; immunoblotting;
   immunohistochemistry; metabolic syndrome
ID NONALCOHOLIC-FATTY-LIVER; CHOLINE-DEFICIENT DIET; METABOLIC SYNDROME;
   OXIDATIVE STRESS; INSULIN-RESISTANCE; PLASMA-MEMBRANE; LIPID DROPLETS;
   MITOCHONDRIAL DYSFUNCTION; EXTRAHEPATIC CHOLESTASIS;
   ENDOPLASMIC-RETICULUM
AB P>Background
   Caveolin-1, the main structural protein of caveolae, is involved in cholesterol homoeostasis, transcytosis, endocytosis and signal transduction and thought to play an important role in lipidogenesis. Little is known about the pathophysiological role of caveolin-1 in nonalcoholic fatty liver disease (NAFLD), a condition frequently associated with the metabolic syndrome and characterized by abnormal accumulation of intrahepatic triglycerides with a potentially harmful risk of evolution to liver fibrosis, cirrhosis and hepatocellular carcinoma.
   Materials and methods
   Liver steatosis (micro/macrovesicular) was induced in adult rats fed a choline-deficient diet for 14 days and compared with a control normal diet. The expression and subcellular distribution of caveolin-1 was assessed using light and electron microscopy by immunohistochemical and immunocytochemical techniques and by Western blotting.
   Results
   Caveolin-1 was mainly associated with the hepatocyte basolateral plasma membrane. Fatty hepatocytes were characterized by a significant increase in the expression of caveolin-1 around and within the lipid droplets as well as in the inner membrane of mitochondria.
   Conclusions
   Our data suggest the involvement of caveolin-1 in the case of abnormal lipogenesis and mitochondrial function typical of steatotic hepatocytes in NAFLD. Addressing the role played by caveolin-1 in liver membranes in NAFLD may help future therapeutic choices in a frequent metabolic liver disease.
C1 [Mastrodonato, Maria; Mentino, Donatella; Ferri, Domenico; Liquori, Giuseppa E.] Aldo Moro Univ, Dept Anim & Environm Biol, Bari, Italy.
   [Calamita, Giuseppe] Aldo Moro Univ, Dept Gen & Environm Physiol, Bari, Italy.
   [Rossi, Roberta] Aldo Moro Univ, Lab Ultrastruct Pathol, Bari, Italy.
   [Bonfrate, Leonilde; Portincasa, Piero] Aldo Moro Univ, Dept Internal Med & Publ Med, Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro; Universita degli Studi di Bari Aldo Moro; Universita degli
   Studi di Bari Aldo Moro
RP Mastrodonato, M (corresponding author), Dipartimento Biol Anim & Ambientale, Lab Istol & Anat Comparata, Via Orabona 4, I-70125 Bari, Italy.
EM m.mastrodonato@biologia.uniba.it
RI Bonfrate, Leonilde/ABH-1835-2021; Rossi, Roberta/J-9137-2016;
   portincasa, piero/J-7245-2018; Mastrodonato, Maria/P-4513-2016
OI portincasa, piero/0000-0001-5359-1471; Calamita,
   Giuseppe/0000-0003-4666-9546; Mastrodonato, Maria/0000-0002-0799-8032;
   Mentino, Donatella/0000-0002-0680-5251; ROSSI,
   Roberta/0000-0003-4586-9044
CR Bloomgarden ZT, 2005, DIABETES CARE, V28, P1518, DOI 10.2337/diacare.28.6.1518
   Calamita G, 2008, AM J PHYSIOL-GASTR L, V295, pG682, DOI 10.1152/ajpgi.90226.2008
   Calamita G, 2007, EXPERT OPIN THER TAR, V11, P1231, DOI 10.1517/14728222.11.9.1231
   Carreras FI, 2003, HEPATOLOGY, V37, P1026, DOI 10.1053/jhep.2003.50170
   Chidlow JH, 2010, CARDIOVASC RES, V86, P219, DOI 10.1093/cvr/cvq075
   Cohen AW, 2005, DIABETES, V54, P679, DOI 10.2337/diabetes.54.3.679
   Cohen AW, 2003, AM J PHYSIOL-CELL PH, V285, pC222, DOI 10.1152/ajpcell.00006.2003
   Da Silva GH, 2009, J GASTROINTEST LIVER, V18, P215
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Fernández MA, 2006, SCIENCE, V313, P1628, DOI 10.1126/science.1130773
   Feron O, 1996, J BIOL CHEM, V271, P22810, DOI 10.1074/jbc.271.37.22810
   Ferri D, 2005, BIOL CELL, V97, P277, DOI 10.1042/BC20040154
   Frank PG, 2007, CELL CYCLE, V6, P115, DOI 10.4161/cc.6.2.3722
   Fujimoto T, 2001, J CELL BIOL, V152, P1079, DOI 10.1083/jcb.152.5.1079
   GRAHAM RC, 1966, J HISTOCHEM CYTOCHEM, V14, P291, DOI 10.1177/14.4.291
   Grattagliano I, 2008, EUR J CLIN INVEST, V38, P523, DOI 10.1111/j.1365-2362.2008.01963.x
   Grattagliano I, 2003, CELL BIOL TOXICOL, V19, P355, DOI 10.1023/B:CBTO.0000013341.73139.fc
   Grattagliano I, 2008, J NUTR BIOCHEM, V19, P491, DOI 10.1016/j.jnutbio.2007.06.011
   Grundy SM, 2005, ARTERIOSCL THROM VAS, V25, P2243, DOI 10.1161/01.ATV.0000189155.75833.c7
   GRUNDY SM, 1990, DM-DIS MON, V36, P641
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hahn-Obercyger M, 2009, J LIPID RES, V50, P98, DOI 10.1194/jlr.M800441-JLR200
   Kulinski A, 2004, J BIOL CHEM, V279, P23916, DOI 10.1074/jbc.M312676200
   Lajoie P, 2009, J CELL BIOL, V185, P381, DOI 10.1083/jcb.200811059
   LE LS, 2009, BIOCHIM BIOPHYS ACTA, V1791, P514
   Li SW, 1996, J BIOL CHEM, V271, P568, DOI 10.1074/jbc.271.1.568
   Li WP, 2001, J CELL SCI, V114, P1397
   Liquori GE, 2004, ACTA HISTOCHEM, V106, P21, DOI 10.1016/j.acthis.2003.10.005
   Liquori GE, 2009, HISTOL HISTOPATHOL, V24, P49, DOI 10.14670/HH-24.49
   Liu PS, 1999, NAT CELL BIOL, V1, P369, DOI 10.1038/14067
   Mantena SK, 2008, FREE RADICAL BIO MED, V44, P1259, DOI 10.1016/j.freeradbiomed.2007.12.029
   Mastrodonato M, 2009, J HISTOCHEM CYTOCHEM, V57, P215, DOI 10.1369/jhc.2008.952234
   Mayoral R, 2007, HEPATOLOGY, V46, P813, DOI 10.1002/hep.21746
   MURATA M, 1995, P NATL ACAD SCI USA, V92, P10339, DOI 10.1073/pnas.92.22.10339
   Musso G, 2010, HEPATOLOGY, V52, P79, DOI 10.1002/hep.23623
   Natarajan SK, 2006, J GASTROEN HEPATOL, V21, P1240, DOI 10.1111/j.1440-1746.2006.04313.x
   Okamoto T, 1998, J BIOL CHEM, V273, P5419, DOI 10.1074/jbc.273.10.5419
   Ostermeyer AG, 2001, J CELL BIOL, V152, P1071, DOI 10.1083/jcb.152.5.1071
   Pacelli C, 2010, J NUTR, V140, P1072, DOI 10.3945/jn.109.116673
   Palasciano G, 2007, CURR PHARM DESIGN, V13, P2193
   Petrosillo G, 2007, BBA-BIOENERGETICS, V1767, P1260, DOI 10.1016/j.bbabio.2007.07.011
   Petruzzelli M, 2007, CURR PHARM DESIGN, V13, P2199
   Podar K, 2006, CANCER LETT, V233, P10, DOI 10.1016/j.canlet.2005.02.035
   Pol A, 2001, J CELL BIOL, V152, P1057, DOI 10.1083/jcb.152.5.1057
   Portincasa P, 2007, J GASTROINTEST LIVER, V16, P167
   Portincasa P, 2006, CURR MED CHEM, V13, P2889, DOI 10.2174/092986706778521878
   Portincasa P, 2006, CLIN SCI, V111, P135, DOI 10.1042/CS20050346
   Portincasa P, 2006, LANCET, V368, P230, DOI 10.1016/S0140-6736(06)69044-2
   Raubenheimer PJ, 2006, DIABETES, V55, P2015, DOI 10.2337/db06-0097
   Razani B, 2002, J BIOL CHEM, V277, P8635, DOI 10.1074/jbc.M110970200
   Razani B, 2001, J CLIN INVEST, V108, P1553, DOI 10.1172/JCI200114611
   REYNOLDS ES, 1963, J CELL BIOL, V17, P208, DOI 10.1083/jcb.17.1.208
   Robenek MJ, 2004, FASEB J, V18, P866, DOI 10.1096/fj.03-0782fje
   Smart EJ, 1996, J BIOL CHEM, V271, P29427, DOI 10.1074/jbc.271.46.29427
   Tauchi-Sato K, 2002, J BIOL CHEM, V277, P44507, DOI 10.1074/jbc.M207712200
   Trigatti BL, 1999, BIOCHEM BIOPH RES CO, V255, P34, DOI 10.1006/bbrc.1998.0123
   Tsai CJ, 2004, AM J CLIN NUTR, V80, P38
   Woudenberg J, 2010, HEPATOLOGY, V51, P1744, DOI 10.1002/hep.23460
   Zhou YH, 2008, INDIAN J MED RES, V128, P157
NR 59
TC 26
Z9 30
U1 0
U2 12
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0014-2972
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD JUN
PY 2011
VL 41
IS 6
BP 642
EP 651
DI 10.1111/j.1365-2362.2010.02459.x
PG 10
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 759FP
UT WOS:000290226400009
PM 21250982
DA 2025-06-11
ER

PT J
AU Murdolo, G
   Bartolini, D
   Tortoioli, C
   Piroddi, M
   Iuliano, L
   Galli, F
AF Murdolo, Giuseppe
   Bartolini, Desiree
   Tortoioli, Cristina
   Piroddi, Marta
   Iuliano, Luigi
   Galli, Francesco
TI Lipokines and oxysterols: Novel adipose-derived lipid hormones linking
   adipose dysfunction and insulin resistance
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Review
DE Adipose tissue; Insulin resistance; Obesity; Oxidative stress;
   Preadipocytes; Oxysterols; 4-Hydroxynonenal; Free radicals
ID MARROW STROMAL CELLS; OXIDATIVE STRESS; ADIPOCYTE DIFFERENTIATION;
   GENE-EXPRESSION; REACTIVE OXYGEN; METABOLIC SYNDROME; PREADIPOCYTE
   DIFFERENTIATION; CHOLESTEROL OXIDATION; IMPAIRED ADIPOGENESIS;
   HYPERTROPHIC OBESITY
AB The expansion of adipose tissue (AT.) is, by definition, a hallmark of obesity. However, not all increases in fat mass are associated with pathophysiological cues. Indeed, whereas a "healthy" fat mass accrual, mainly in the subcutaneous depots, preserves metabolic homeostasis, explaining the occurrence of the metabolically healthy obese phenotype, "unhealthy" AT expansion is importantly associated with insulin resistance/type 2 diabetes and the metabolic syndrome. The development of a dysfunctional adipose organ may find mechanistic explanation in a reduced ability to recruit new and functional (pre)adipocytes from undifferentiated precursor cells. Such a failure of the adipogenic process underlies the "AT expandability" paradigm. The inability of AT to expand further to store excess nutrients, rather than obesity per se, induces a diabetogenic milieu by promoting the overflow and the ectopic deposition of fatty acids in insulin-dependent organs (i.e., lipotoxicity), the secretion of various metabolically detrimental adipose-derived hormones (i.e., adipoldnes and lipokines), and the occurrence of local and systemic inflammation and oxidative stress. Hitherto, fatty acids (i.e., lipokines) and the oxidation by-products of cholesterol and polyunsaturated fatty acids, such as nonenzymatic oxysterols and reactive aldehyde species, respectively, emerge as key modulators of (pre)adipocyte signaling through Wnt/beta-catenin and MAPK pathways and potential regulators of glucose homeostasis. These and other mechanistic insights linking adipose dysfunction, oxidative stress, and impairment of glucose homeostasis are discussed in this review article, which focuses on adipose peroxidation as a potential instigator of, and a putative therapeutic target for, obesity-associated metabolic dysfunctions. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Murdolo, Giuseppe] Assisi Hosp, Dept Internal Med, I-06081 Perugia, Italy.
   [Bartolini, Desiree; Piroddi, Marta; Galli, Francesco] Univ Perugia, Dept Internal Med, Sect Appl Biochem & Nutr Sci, I-06100 Perugia, Italy.
   [Iuliano, Luigi] Univ Roma La Sapienza, Dept Med Surg Sci & Biotechnol, Unit Vasc Med, Latina, Italy.
C3 University of Perugia; University of Perugia; Sapienza University Rome
RP Murdolo, G (corresponding author), Assisi Hosp, Dept Internal Med, I-06081 Perugia, Italy.
EM gmurdolo@tiscali.it
RI Murdolo, Giuseppe/I-1812-2012; Iuliano, Luigi/A-5266-2008; Galli,
   Francesco/K-5048-2016; Bartolini, Desiree/K-5319-2016; Piroddi,
   Marta/K-5302-2016
OI Iuliano, Luigi/0000-0002-0027-9326; Galli,
   Francesco/0000-0003-3626-051X; Bartolini, Desiree/0000-0003-3849-757X;
   Piroddi, Marta/0000-0002-0880-0630; Murdolo,
   Giuseppe/0000-0001-5654-1760
FU Fondazione Cassa di Risparmio di Perugia (Project "Ricerca Scientifica e
   Tecnologica") [2010.020.0098]
FX This work was partly funded by a grant from the Fondazione Cassa di
   Risparmio di Perugia (Project 2010.020.0098 "Ricerca Scientifica e
   Tecnologica"). The authors acknowledge Mrs. Chiara Baccellini and Mrs.
   Martina Spinsanti for their valuable collaboration.
CR Amantea CM, 2008, J CELL BIOCHEM, V105, P424, DOI 10.1002/jcb.21840
   Andersson CX, 2008, DIABETES-METAB RES, V24, P595, DOI 10.1002/dmrr.889
   [Anonymous], 2017, Annex 3-03, P4
   [Anonymous], ANTIOXID RE IN PRESS
   Arner P, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0018284
   Bashan N, 2009, PHYSIOL REV, V89, P27, DOI 10.1152/physrev.00014.2008
   Blüher M, 2010, CURR OPIN LIPIDOL, V21, P38, DOI 10.1097/MOL.0b013e3283346ccc
   Bost F, 2005, BIOCHIMIE, V87, P51, DOI 10.1016/j.biochi.2004.10.018
   Bouchard L, 2010, AM J CLIN NUTR, V91, P309, DOI 10.3945/ajcn.2009.28085
   Bouchard L, 2009, OBESITY, V17, P1466, DOI 10.1038/oby.2009.71
   Bowers RR, 2008, CELL CYCLE, V7, P1191, DOI 10.4161/cc.7.9.5815
   Brandon L. J., 2012, J CLIN ENDOCRINOL ME, V97
   Brown AJ, 1997, J LIPID RES, V38, P1730
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Cao HM, 2008, CELL, V134, P933, DOI 10.1016/j.cell.2008.07.048
   Christodoulides C, 2009, TRENDS ENDOCRIN MET, V20, P16, DOI 10.1016/j.tem.2008.09.002
   Chui PC, 2005, J CLIN INVEST, V115, P2244, DOI 10.1172/JCI24130
   Cinti S, 2012, DIS MODEL MECH, V5, P588, DOI 10.1242/dmm.009662
   CURZIO M, 1987, BIOMED PHARMACOTHER, V41, P304
   Dalla Libera A, 1998, FREE RADICAL RES, V29, P151
   Danforth E, 2000, NAT GENET, V26, P13, DOI 10.1038/79111
   Demozay D, 2004, J BIOL CHEM, V279, P6261, DOI 10.1074/jbc.M312062200
   Demozay D, 2008, DIABETES, V57, P1216, DOI 10.2337/db07-0389
   Descamps S, 2008, CELL TISSUE RES, V332, P299, DOI 10.1007/s00441-008-0574-z
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Dubois SG, 2006, OBESITY, V14, P1543, DOI 10.1038/oby.2006.178
   Dwyer JR, 2007, J BIOL CHEM, V282, P8959, DOI 10.1074/jbc.M611741200
   Endo K, 2008, DIABETES RES CLIN PR, V80, P63, DOI 10.1016/j.diabres.2007.10.023
   Evans JL, 2005, ANTIOXID REDOX SIGN, V7, P1040, DOI 10.1089/ars.2005.7.1040
   Evans JL, 2007, INDIAN J MED RES, V125, P355
   Ferderbar S, 2007, DIABETES-METAB RES, V23, P35, DOI 10.1002/dmrr.645
   Fève B, 2005, BEST PRACT RES CL EN, V19, P483, DOI 10.1016/j.beem.2005.07.007
   Findeisen HM, 2011, OBESITY, V19, P2429, DOI 10.1038/oby.2011.298
   Findeisen HM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0018532
   Finkel T, 2000, NATURE, V408, P239, DOI 10.1038/35041687
   Funato Y, 2010, FREE RADICAL RES, V44, P379, DOI 10.3109/10715761003610745
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Galinier A, 2006, J BIOL CHEM, V281, P12682, DOI 10.1074/jbc.M506949200
   Goldstein BJ, 2005, DIABETES, V54, P311, DOI 10.2337/diabetes.54.2.311
   Gómez-Ambrosi J, 2012, INT J OBESITY, V36, P286, DOI 10.1038/ijo.2011.100
   Goossens GH, 2008, PHYSIOL BEHAV, V94, P206, DOI 10.1016/j.physbeh.2007.10.010
   Grant SFA, 2006, NAT GENET, V38, P320, DOI 10.1038/ng1732
   Grimsrud PA, 2007, MOL CELL PROTEOMICS, V6, P624, DOI 10.1074/mcp.M600120-MCP200
   GRUNDY SM, 1991, ANN INTERN MED, V115, P956
   Gummersbach C, 2009, DIFFERENTIATION, V77, P115, DOI 10.1016/j.diff.2008.09.009
   Guo W, 2007, AM J PHYSIOL-ENDOC M, V293, pE576, DOI 10.1152/ajpendo.00523.2006
   Gustafson B, 2008, DIABETOLOGIA, V51, P1768, DOI 10.1007/s00125-008-1109-6
   Gustafson B, 2006, J BIOL CHEM, V281, P9507, DOI 10.1074/jbc.M512077200
   Gustafson B, 2010, DIABETOLOGIA, V53, P536, DOI 10.1007/s00125-009-1615-1
   Gustafson B, 2007, ARTERIOSCL THROM VAS, V27, P2276, DOI 10.1161/ATVBAHA.107.147835
   Gustafson B, 2012, DIABETES, V61, P1217, DOI 10.2337/db11-1419
   Gustafson B, 2010, J BIOL CHEM, V285, P14031, DOI 10.1074/jbc.M110.102855
   Gustafson B, 2009, AM J PHYSIOL-ENDOC M, V297, pE999, DOI 10.1152/ajpendo.00377.2009
   Hammarstedt A, 2003, BIOCHEM BIOPH RES CO, V301, P578, DOI 10.1016/S0006-291X(03)00014-7
   Hammarstedt A, 2007, BIOCHEM BIOPH RES CO, V357, P700, DOI 10.1016/j.bbrc.2007.03.202
   Hemmrich K, 2006, MOL PSYCHIATR, V11, P980, DOI 10.1038/sj.mp.4001892
   Hill BG, 2008, BIOCHEM J, V410, P525, DOI 10.1042/BJ20071063
   Hodson L, 2008, PROG LIPID RES, V47, P348, DOI 10.1016/j.plipres.2008.03.003
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Iggman D, 2010, DIABETOLOGIA, V53, P850, DOI 10.1007/s00125-010-1669-0
   Isakson P, 2009, DIABETES, V58, P1550, DOI 10.2337/db08-1770
   Iuliano L, 2011, CHEM PHYS LIPIDS, V164, P457, DOI 10.1016/j.chemphyslip.2011.06.006
   Iuliano L, 2009, AM J CLIN NUTR, V90, P477, DOI 10.3945/ajcn.2009.27757
   Janowski BA, 1996, NATURE, V383, P728, DOI 10.1038/383728a0
   Janssen-Heininger YMW, 2008, FREE RADICAL BIO MED, V45, P1, DOI 10.1016/j.freeradbiomed.2008.03.011
   Kha HT, 2004, J BONE MINER RES, V19, P830, DOI 10.1359/JBMR.040115
   Kikuchi A, 2009, TRENDS CELL BIOL, V19, P119, DOI 10.1016/j.tcb.2009.01.003
   Kim WK, 2007, J BONE MINER RES, V22, P1711, DOI 10.1359/JBMR.070710
   Klöting N, 2010, AM J PHYSIOL-ENDOC M, V299, pE506, DOI 10.1152/ajpendo.00586.2009
   KRAUSE BR, 1984, J LIPID RES, V25, P97
   Krishnan V, 2006, J CLIN INVEST, V116, P1202, DOI 10.1172/JCI28551
   Lagathu C, 2009, DIABETES, V58, P609, DOI 10.2337/db08-1180
   Le Lay S, 2001, J BIOL CHEM, V276, P16904, DOI 10.1074/jbc.M010955200
   Lee H, 2009, J BIOL CHEM, V284, P10601, DOI 10.1074/jbc.M808742200
   Logan CY, 2004, ANNU REV CELL DEV BI, V20, P781, DOI 10.1146/annurev.cellbio.20.010403.113126
   Luchetti F, 2010, FASEB J, V24, P3603, DOI 10.1096/fj.10-154450
   LULIANO L, 1992, LIPIDS, V27, P349, DOI 10.1007/BF02536149
   Lundgren M, 2007, DIABETOLOGIA, V50, P625, DOI 10.1007/s00125-006-0572-1
   Madsen L, 2005, BBA-MOL BASIS DIS, V1740, P266, DOI 10.1016/j.bbadis.2005.03.001
   Mann RK, 2004, ANNU REV BIOCHEM, V73, P891, DOI 10.1146/annurev.biochem.73.011303.073933
   Manolagas SC, 2007, MOL ENDOCRINOL, V21, P2605, DOI 10.1210/me.2007-0259
   Masella R, 2006, FEBS LETT, V580, P2421, DOI 10.1016/j.febslet.2006.03.068
   Mattson MP, 2009, EXP GERONTOL, V44, P625, DOI 10.1016/j.exger.2009.07.003
   Miwa I, 2000, ENDOCRINOLOGY, V141, P2767, DOI 10.1210/en.141.8.2767
   Mogensen M, 2007, DIABETES, V56, P1592, DOI 10.2337/db06-0981
   MOLLER DE, 1991, NEW ENGL J MED, V325, P938
   Mouche S, 2007, BBA-MOL CELL RES, V1773, P1015, DOI 10.1016/j.bbamcr.2007.03.003
   Mozaffarian D, 2010, AM J CLIN NUTR, V92, P1350, DOI 10.3945/ajcn.110.003970
   Murdolo G, 2006, NUTR METAB CARDIOVAS, V16, pS35, DOI 10.1016/j.numecd.2005.10.016
   Murdolo G, 2008, AM J PHYSIOL-ENDOC M, V295, pE1095, DOI 10.1152/ajpendo.90483.2008
   Murdolo G, 2007, J CLIN ENDOCR METAB, V92, P2688, DOI 10.1210/jc.2006-2814
   Murphy C, 2007, BIOCHEM BIOPH RES CO, V355, P359, DOI 10.1016/j.bbrc.2007.01.155
   Olkkonen VM, 2009, MOL ASPECTS MED, V30, P123, DOI 10.1016/j.mam.2009.02.004
   Otaegui-Arrazola A, 2010, FOOD CHEM TOXICOL, V48, P3289, DOI 10.1016/j.fct.2010.09.023
   Park HT, 2012, CLIN ENDOCRINOL, V76, P59, DOI 10.1111/j.1365-2265.2011.04141.x
   Park JR, 2008, CELL PROLIFERAT, V41, P859, DOI 10.1111/j.1365-2184.2008.00565.x
   Pillon NJ, 2012, ENDOCRINOLOGY, V153, P2099, DOI 10.1210/en.2011-1957
   Pillon NJ, 2011, CHEM RES TOXICOL, V24, P752, DOI 10.1021/tx200084d
   Pillon NJ, 2010, CHEM-BIOL INTERACT, V188, P171, DOI 10.1016/j.cbi.2010.06.015
   Piroddi M, 2013, BLOOD PURIFICAT, V35, P30, DOI 10.1159/000350846
   Poli G, 2008, MED RES REV, V28, P569, DOI 10.1002/med.20117
   Prestwich TC, 2007, CURR OPIN CELL BIOL, V19, P612, DOI 10.1016/j.ceb.2007.09.014
   Puri V, 2008, P NATL ACAD SCI USA, V105, P7833, DOI 10.1073/pnas.0802063105
   Rao TP, 2010, CIRC RES, V106, P1798, DOI 10.1161/CIRCRESAHA.110.219840
   Riahi Y, 2010, AM J PHYSIOL-ENDOC M, V299, pE879, DOI 10.1152/ajpendo.00508.2010
   Roberts R, 2009, DIABETOLOGIA, V52, P882, DOI 10.1007/s00125-009-1300-4
   Rosen ED, 2006, NAT REV MOL CELL BIO, V7, P885, DOI 10.1038/nrm2066
   Ross SE, 2000, SCIENCE, V289, P950, DOI 10.1126/science.289.5481.950
   Roth GS, 2002, SCIENCE, V297, P811, DOI 10.1126/science.1071851
   Ruderman N, 1998, DIABETES, V47, P699, DOI 10.2337/diabetes.47.5.699
   Scazzocchio B, 2009, J LIPID RES, V50, P832, DOI 10.1194/jlr.M800402-JLR200
   Schroeder K, 2009, ARTERIOSCL THROM VAS, V29, P239, DOI 10.1161/ATVBAHA.108.174219
   Sethi JK, 2010, DIABETES, V59, P2354, DOI 10.2337/db10-0923
   Sethi JK, 2010, BIOCHEM J, V427, P1, DOI 10.1042/BJ20091866
   Singh SP, 2008, BIOCHEMISTRY-US, V47, P3900, DOI 10.1021/bi702124u
   Smith U, 1999, ANN NY ACAD SCI, V892, P119, DOI 10.1111/j.1749-6632.1999.tb07790.x
   Smith U, 2002, INT J OBESITY, V26, P897, DOI 10.1038/sj.ijo.0802028
   Smith U, 2010, BBA-MOL CELL BIOL L, V1801, P377, DOI 10.1016/j.bbalip.2009.11.006
   Soares AF, 2005, FREE RADICAL BIO MED, V38, P882, DOI 10.1016/j.freeradbiomed.2004.12.010
   Speliotes EK, 2010, NAT GENET, V42, P937, DOI 10.1038/ng.686
   Stefan N, 2008, ARCH INTERN MED, V168, P1609, DOI 10.1001/archinte.168.15.1609
   Stefan N, 2010, DIABETES CARE, V33, P405, DOI [10.2337/dc09-0544, 10.2337/dc10-0002]
   Sun K, 2011, J CLIN INVEST, V121, P2094, DOI 10.1172/JCI45887
   Toyokuni S, 2000, ANTIOXID REDOX SIGN, V2, P681, DOI 10.1089/ars.2000.2.4-681
   Trepanowski JF, 2011, NUTR J, V10, DOI 10.1186/1475-2891-10-107
   van Tienen FHJ, 2011, INT J OBESITY, V35, P1154, DOI 10.1038/ijo.2010.275
   Virtue S, 2010, BBA-MOL CELL BIOL L, V1801, P338, DOI 10.1016/j.bbalip.2009.12.006
   Waki H, 2007, CELL METAB, V5, P357, DOI 10.1016/j.cmet.2007.03.010
   Wamil M, 2008, ENDOCRINOLOGY, V149, P5909, DOI 10.1210/en.2008-0420
   Wang MY, 2008, P NATL ACAD SCI USA, V105, P6139, DOI 10.1073/pnas.0801981105
   Weyer C, 2000, DIABETOLOGIA, V43, P1498, DOI 10.1007/s001250051560
   Willert K, 2003, NATURE, V423, P448, DOI 10.1038/nature01611
   Yang XL, 2004, BIOCHEM BIOPH RES CO, V317, P1045, DOI 10.1016/j.bbrc.2004.03.152
   Zarrouki B, 2007, FEBS LETT, V581, P2394, DOI 10.1016/j.febslet.2007.04.048
   Zhang YY, 2011, AM J PHYSIOL-ENDOC M, V300, pE77, DOI 10.1152/ajpendo.00380.2010
   Zhou T, 2011, DIABETOLOGIA, V54, P459, DOI 10.1007/s00125-010-1943-1
   Zhou Y., 2011, PLOS ONE, V7
NR 137
TC 45
Z9 48
U1 0
U2 30
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD DEC
PY 2013
VL 65
BP 811
EP 820
DI 10.1016/j.freeradbiomed.2013.08.007
PG 10
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 278DI
UT WOS:000328868900076
PM 23954331
DA 2025-06-11
ER

PT J
AU Chen, TH
   Kung, WS
   Sun, HY
   Huang, JJ
   Lu, JY
   Luo, KH
   Chuang, HY
AF Chen, Tzu-Hua
   Kung, Wei-Shyang
   Sun, Hung-Yu
   Huang, Joh-Jong
   Lu, Jia-Yi
   Luo, Kuei-Hau
   Chuang, Hung-Yi
TI The Relationship between Metabolic Syndrome and Plasma Metals Modified
   by EGFR and TNF-α Gene Polymorphisms
SO TOXICS
LA English
DT Article
DE metabolic disorders; metabolic syndrome; epidermal growth factor
   receptor (EGFR); TNF-alpha; single nucleotide polymorphism (SNP);
   metals; inflammation; insulin resistance; Taiwan biobank
ID OXIDATIVE STRESS; HEAVY-METALS; ASSOCIATION; RECEPTOR; HYPERTENSION;
   PREVALENCE; PROTEIN; HEALTH; RISK
AB With the escalating global prevalence of metabolic syndrome (MetS), it is crucial to detect the high-risk population early and to prevent chronic diseases. Exposure to various metals has been indicated to promote MetS, but the findings were controversial, and the effect of genetic modification was not considered. Epidermal growth factor receptor (EGFR) was proposed to be involved in the pathway of metabolic disorders, and tumor necrotic factor-alpha (TNF-alpha) was regarded as an early inflammatory biomarker for MetS. This research aimed to analyze the impact of EGFR and TNF-alpha gene polymorphisms on the prevalence of MetS under environmental or occupational exposure to metals. We gathered data from 376 metal industrial workers and 639 non-metal workers, including physical parameters, biochemical data, and plasma concentrations of six metals. According to the genomic database of Taiwan Biobank, 23 single nucleotide polymorphisms (SNPs) on EGFR gene and 6 SNPs on TNF-alpha gene were incorporated in our research. We applied multivariable logistic regression to analyze the probability of MetS with various SNPs and metals. Our study revealed some susceptible and protective EGFR and TNF-alpha genotypes under excessive exposure to cobalt, zinc, selenium, and lead. Thus, we remind the high-risk population of taking measures to prevent MetS.
C1 [Chen, Tzu-Hua; Lu, Jia-Yi; Chuang, Hung-Yi] Kaohsiung Med Univ, Coll Hlth Sci, Dept Publ Hlth, Kaohsiung 80708, Taiwan.
   [Chen, Tzu-Hua] Kaohsiung Municipal Tatung Hosp, Dept Family Med, Kaohsiung 80145, Taiwan.
   [Chen, Tzu-Hua; Huang, Joh-Jong] Kaohsiung Med Univ Hosp, Dept Family Med, Kaohsiung 80708, Taiwan.
   [Kung, Wei-Shyang] Chien Shin Hosp, Dept Pediat, Kaohsiung 80143, Taiwan.
   [Sun, Hung-Yu] Changhua Christian Hosp, Dept Family Med, Changhua 50006, Taiwan.
   [Luo, Kuei-Hau] Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung 80708, Taiwan.
   [Chuang, Hung-Yi] Kaohsiung Med Univ Hosp, Dept Environm & Occupat Med, Kaohsiung 80708, Taiwan.
   [Chuang, Hung-Yi] Kaohsiung Med Univ, Coll Med, Res Ctr Environm Med, PhD Program Environm & Occupat Med, Kaohsiung 80708, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University; Kaohsiung
   Municipal Ta-Tung Hospital; Kaohsiung Medical University; Kaohsiung
   Medical University Hospital; Changhua Christian Hospital; Kaohsiung
   Medical University; Kaohsiung Medical University; Kaohsiung Medical
   University Hospital; Kaohsiung Medical University
RP Chuang, HY (corresponding author), Kaohsiung Med Univ, Coll Hlth Sci, Dept Publ Hlth, Kaohsiung 80708, Taiwan.; Chuang, HY (corresponding author), Kaohsiung Med Univ Hosp, Dept Environm & Occupat Med, Kaohsiung 80708, Taiwan.; Chuang, HY (corresponding author), Kaohsiung Med Univ, Coll Med, Res Ctr Environm Med, PhD Program Environm & Occupat Med, Kaohsiung 80708, Taiwan.
EM 980264@kmuh.org.tw; u104862002@kmu.edu.tw; 144107@cch.org.tw;
   1030578@kmuh.org.tw; u105570008@kmu.edu.tw; u107800007@kmu.edu.tw;
   ericch@kmu.edu.tw
RI Chuang, Hung-Yi/C-9143-2009; Lu, Jiayi/IQS-9529-2023
FU Ministry of Science and Technology of Taiwan [MOST 109-2911-I-037-501];
   Kaohsiung Medical University Hospital [KMUH1099T05]; Kaohsiung Medical
   University [KMU-TC109A01-1]; Kaohsiung Municipal Ta-Tung Hospital
   [kmtth-109-003]
FX This research was funded by the Ministry of Science and Technology of
   Taiwan (Grant number: MOST 109-2911-I-037-501) and grants from Kaohsiung
   Medical University Hospital (KMUH1099T05), Kaohsiung Medical University
   (KMU-TC109A01-1) and Kaohsiung Municipal Ta-Tung Hospital
   (kmtth-109-003).
CR Alfthan G, 1996, J TRACE ELEM MED BIO, V10, P77, DOI 10.1016/S0946-672X(96)80015-0
   Anderson CA, 2010, NAT PROTOC, V5, P1564, DOI 10.1038/nprot.2010.116
   Beltowski J, 2009, MINI-REV MED CHEM, V9, P526, DOI 10.2174/138955709788167619
   Bhushan B, 2020, CHEM-BIOL INTERACT, V324, DOI 10.1016/j.cbi.2020.109090
   Borst SE, 2004, ENDOCRINE, V23, P177, DOI 10.1385/ENDO:23:2-3:177
   Brown AE, 2016, CURR CARDIOL REP, V18, DOI 10.1007/s11886-016-0755-4
   Bulka CM, 2019, ENVIRON RES, V168, P397, DOI 10.1016/j.envres.2018.10.022
   Burton PR, 2007, NATURE, V447, P661, DOI 10.1038/nature05911
   Catalani Simona, 2011, ISRN Hematol, V2011, P690620, DOI 10.5402/2011/690620
   Chen CH, 2016, HUM MOL GENET, V25, P5321, DOI 10.1093/hmg/ddw346
   Chen TH, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16214079
   Chen TH, 2014, KAOHSIUNG J MED SCI, V30, P86, DOI 10.1016/j.kjms.2013.09.001
   Choung S, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0210828
   Daijo K, 2020, J GASTROEN HEPATOL, V35, P1412, DOI 10.1111/jgh.14968
   Dong LM, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004895
   Emara M, 2020, MEDIAT INFLAMM, V2020, DOI 10.1155/2020/1498278
   Fabris M, 2002, J RHEUMATOL, V29, P29
   Fernandez-Patron C, 2007, CAN J PHYSIOL PHARM, V85, P97, DOI 10.1139/Y06-097
   Fröhlich M, 2000, DIABETES CARE, V23, P1835, DOI 10.2337/diacare.23.12.1835
   Gaetke LM, 2003, TOXICOLOGY, V189, P147, DOI 10.1016/S0300-483X(03)00159-8
   Gomez-Delgado F, 2014, MOL NUTR FOOD RES, V58, P1519, DOI 10.1002/mnfr.201300723
   Guo XL, 2019, ENVIRON POLLUT, V248, P66, DOI 10.1016/j.envpol.2019.02.015
   Gupta S, 2015, J DIABETES COMPLICAT, V29, P338, DOI 10.1016/j.jdiacomp.2015.01.002
   Hajeer AH, 2001, HUM IMMUNOL, V62, P1191, DOI 10.1016/S0198-8859(01)00322-6
   Hess SY, 2007, FOOD NUTR BULL, V28, pS403, DOI 10.1177/15648265070283S303
   Hwang LC, 2006, J FORMOS MED ASSOC, V105, P626, DOI 10.1016/S0929-6646(09)60161-3
   Jiang YD, 2012, J FORMOS MED ASSOC, V111, P599, DOI 10.1016/j.jfma.2012.09.014
   Jou YS, 2009, LUNG CANCER, V64, P251, DOI 10.1016/j.lungcan.2008.09.014
   Kwaifa IK, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10020291
   Li CY, 1999, OCCUP MED-OXFORD, V49, P225, DOI 10.1093/occmed/49.4.225
   Li Zl, 2018, DIABETES, V67, P1847, DOI 10.2337/db17-1513
   Lin E, 2016, SCI REP-UK, V6, DOI 10.1038/srep36830
   Ma JX, 2020, ENVIRON INT, V140, DOI 10.1016/j.envint.2020.105802
   Matys T, 2020, J CLIN MED, V9, DOI 10.3390/jcm9041040
   Moon YS, 2004, METABOLISM, V53, P863, DOI 10.1016/j.metabol.2004.02.007
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Moy FM, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-678
   Panchal SK, 2017, CURR HYPERTENS REP, V19, DOI 10.1007/s11906-017-0701-x
   Povel CM, 2011, OBES REV, V12, P952, DOI 10.1111/j.1467-789X.2011.00907.x
   Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795
   Ranasinghe P, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4041-1
   Rhee SY, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-9
   Rotter I, 2015, INT J ENV RES PUB HE, V12, P3944, DOI 10.3390/ijerph120403944
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Scheving LA, 2014, AM J PHYSIOL-GASTR L, V306, pG370, DOI 10.1152/ajpgi.00116.2013
   Schlessinger J, 2002, CELL, V110, P669, DOI 10.1016/S0092-8674(02)00966-2
   Srikanthan K, 2016, INT J MED SCI, V13, P25, DOI 10.7150/ijms.13800
   Tchounwou P., 2012, MOL CLIN ENV TOXICOL, V101, P133, DOI DOI 10.1007/978-3-7643-8340-4
   Wang D, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-83321-x
   Wang YM, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000015137
   Wen WL, 2020, NUTRIENTS, V12, DOI 10.3390/nu12092666
   Wilson PWF, 2005, CIRCULATION, V112, P3066, DOI 10.1161/CIRCULATIONAHA.105.539528
   Yue X, 2020, INT J IMMUNOGENET, V47, P286, DOI 10.1111/iji.12474
NR 53
TC 2
Z9 2
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2305-6304
J9 TOXICS
JI Toxics
PD SEP
PY 2021
VL 9
IS 9
AR 225
DI 10.3390/toxics9090225
PG 13
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA UX8CG
UT WOS:000701065900001
PM 34564376
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, CH
   Noh, IK
   Ryu, JM
   Bae, EJ
   Cho, HJ
   Kim, MS
AF Kim, Chul-Hoon
   Noh, In-Kyoung
   Ryu, Jung Mi
   Bae, Eun Jung
   Cho, Hoo Jeung
   Kim, Myoung Soo
TI Canonical Correlation between Behavioral-Psychological Variables and
   Predictors of Coronary Artery Disease Prognosis
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE coronary artery disease; lifestyle; metabolic syndrome; severity of
   illness index; type-D personality
ID D PERSONALITY; METABOLIC SYNDROME; NEGATIVE AFFECTIVITY; SOCIAL
   INHIBITION; HEART-DISEASE; RISK-FACTORS; FOLLOW-UP; PREVALENCE;
   SEVERITY; CONSEQUENCES
AB Metabolic syndrome (MetS) and severity of coronary artery disease (CAD) are considered predictors of CAD prognosis. Unhealthy lifestyles and type-D personality are associated with MetS and are potential causes of primary and secondary CAD. In this cross-sectional descriptive study, we aimed to investigate the relationship between behavioral-psychological variables and predictors of CAD prognosis. The behavioral-psychological variable set contained six lifestyle categories and two type-D personality categories. Descriptive analyses, t-tests, analysis of variance, Pearson's correlation, and canonical correlation were used. The behavioral-psychological variable set was related to the predictor set for CAD prognosis, with a significant canonical variate of 0.67 (45% overlapping variance). Significant pairs of canonical variates indicated that poor physical activity and weight control (-0.77), poor dietary habits (-0.78), alcohol consumption and cigarette smoking (-0.37), lack of sleep and rest (-0.40), stress (-0.64) in the lifestyle set, higher negative affectivity (0.52), and social inhibition (0.71) in the type-D personality set were associated with a high MetS score (0.59) and severity of CAD (0.91). A combination of behavioral and psychological variables was found to be important in predicting the prognosis of CAD; therefore, interventions aimed at preventing combinations of these variables may be effective in improving CAD prognosis.
C1 [Kim, Chul-Hoon] Dong A Univ, Coll Med, Busan 49201, South Korea.
   [Noh, In-Kyoung] Kosin Univ, Dept Internal Med, Gospel Hosp, Busan 49267, South Korea.
   [Ryu, Jung Mi; Bae, Eun Jung; Cho, Hoo Jeung; Kim, Myoung Soo] Pukyong Natl Univ, Dept Nursing, Busan 48513, South Korea.
   [Bae, Eun Jung] Dongnam Inst Radiol & Med Sci, Dept Nursing, Busan 46033, South Korea.
C3 Dong A University; Pukyong National University; Korea Institute of
   Radiological & Medical Sciences
RP Kim, MS (corresponding author), Pukyong Natl Univ, Dept Nursing, Busan 48513, South Korea.
EM bbp2000@hanmail.net; ada10kr@naver.com; rewmis@naver.com;
   beaulife-@hanmail.net; ccu0401@naver.com; kanosa@pknu.ac.kr
RI Kim, Young/T-8521-2019; Kim, Chang/H-4759-2011
OI Kim, Myoung Soo/0000-0002-1773-1374
FU Dong-A University research fund
FX This work was supported by the Dong-A University research fund.
CR Albus C, 2011, J PSYCHOSOM RES, V71, P215, DOI 10.1016/j.jpsychores.2011.02.013
   강세원, 2010, [The Journal of Fundamentals of Nursing, 기본간호학회지], V17, P487
   [Anonymous], USING MULTIVARIATE S
   [Anonymous], J KOREAN SOC MENOPAU
   Bauters C, 2014, AM J CARDIOL, V113, P1142, DOI 10.1016/j.amjcard.2013.12.019
   Bayturan O, 2010, ARCH INTERN MED, V170, P478, DOI 10.1001/archinternmed.2009.551
   Booth L, 2015, J HEALTH PSYCHOL, V20, P921, DOI 10.1177/1359105315573433
   Bunevicius A, 2014, INT J BEHAV MED, V21, P240, DOI 10.1007/s12529-013-9299-9
   Carbonara R, 2017, CURR NEUROVASC RES, V14, P39, DOI 10.2174/1567202614666161107105712
   Carney CE, 2017, SLEEP, V40, DOI 10.1093/sleep/zsx019
   Cohen BE, 2015, AM J HYPERTENS, V28, P1295, DOI 10.1093/ajh/hpv047
   Dannemann S, 2010, J PSYCHOSOM RES, V69, P101, DOI 10.1016/j.jpsychores.2010.02.008
   Denollet J, 2005, PSYCHOSOM MED, V67, P89, DOI 10.1097/01.psy.0000149256.81953.49
   Denollet J, 2018, INT J CARDIOL, V259, P205, DOI 10.1016/j.ijcard.2018.02.064
   Denollet J, 2013, PSYCHOSOM MED, V75, P873, DOI 10.1097/PSY.0000000000000001
   DiNicolantonio JJ, 2016, PROG CARDIOVASC DIS, V58, P464, DOI 10.1016/j.pcad.2015.11.006
   Fox KAA, 2010, EUR HEART J, V31, P2755, DOI 10.1093/eurheartj/ehq326
   Gheorghe A, 2018, BMC PUBLIC HEALTH, V18, DOI 10.1186/s12889-018-5806-x
   Gilmour J, 2012, J HEALTH PSYCHOL, V17, P471, DOI 10.1177/1359105311423117
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Gui MH, 2017, CHINESE MED J-PEKING, V130, P669, DOI 10.4103/0366-6999.201611
   Hausteiner C, 2010, PSYCHOSOM MED, V72, P163, DOI 10.1097/PSY.0b013e3181cb8bae
   Iorga A, 2017, BIOL SEX DIFFER, V8, DOI 10.1186/s13293-017-0152-8
   Kelpis TG, 2013, HELL J CARDIOL, V54, P362
   Kim I, 2018, AM J CARDIOL, V122, P192, DOI 10.1016/j.amjcard.2018.03.366
   Kim JH, 2019, AM J CARDIOL, V123, P874, DOI 10.1016/j.amjcard.2018.11.057
   Klempfner R, 2016, CIRC-CARDIOVASC QUAL, V9, P100, DOI 10.1161/CIRCOUTCOMES.115.002104
   Kolovou G, 2015, CURR MED CHEM, V22, P3555, DOI 10.2174/0929867322666150904105941
   Kupper N, 2018, CURR CARDIOL REP, V20, DOI 10.1007/s11886-018-1048-x
   Lee JM, 2019, J AM COLL CARDIOL, V73, P2413, DOI 10.1016/j.jacc.2019.02.060
   Lee SJ, 2018, ANN REHABIL MED-ARM, V42, P748, DOI 10.5535/arm.2018.42.5.748
   Lee SE, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194490
   Leu HB, 2019, J FORMOS MED ASSOC, V118, P721, DOI 10.1016/j.jfma.2018.08.021
   Lim HE, 2011, J KOREAN MED SCI, V26, P116, DOI 10.3346/jkms.2011.26.1.116
   Maroszynska-Dmoch EM, 2016, KARDIOL POL, V74, P314, DOI 10.5603/KP.a2015.0178
   Michal M, 2013, TRIALS, V14, DOI 10.1186/1745-6215-14-314
   Newhouse A, 2014, HEART FAIL CLIN, V10, P295, DOI 10.1016/j.hfc.2013.10.004
   Ormazabal V, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0762-4
   Patterson R, 2018, EUR J EPIDEMIOL, V33, P811, DOI 10.1007/s10654-018-0380-1
   Pedersen SS, 2006, CURR CARDIOL REV, V2, P205, DOI 10.2174/157340306778019441
   Pelliccia F, 2020, AM J MED, V133, P73, DOI 10.1016/j.amjmed.2019.05.048
   Pepine CJ, 2006, J AM COLL CARDIOL, V47, P547, DOI 10.1016/j.jacc.2005.09.031
   Schoenenberger AW, 2010, CLIN CARDIOL, V33, P289, DOI 10.1002/clc.20775
   Severino P, 2019, CARDIOL RES PRACT, V2019, DOI 10.1155/2019/1208505
   Severino P, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19030802
   Shimokawa H, 2014, EUR HEART J, V35, P3180, DOI 10.1093/eurheartj/ehu427
   Smaardijk VR, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.118.010859
   Svansdottir E, 2013, EUR J PREV CARDIOL, V20, P322, DOI 10.1177/2047487312441723
   Tune JD, 2017, TRANSL RES, V183, P57, DOI 10.1016/j.trsl.2017.01.001
   Varghese T, 2016, HEART, V102, P904, DOI 10.1136/heartjnl-2015-308773
   Venuleo C, 2018, FRONT PSYCHOL, V9, DOI 10.3389/fpsyg.2018.00976
   Wake Ryotaro, 2009, Recent Pat Cardiovasc Drug Discov, V4, P234
   Whitehead DL, 2007, J PSYCHOSOM RES, V62, P419, DOI 10.1016/j.jpsychores.2006.11.005
   Wiley JF, 2016, PREV MED, V88, P189, DOI 10.1016/j.ypmed.2016.04.006
   Williams L, 2008, J PSYCHOSOM RES, V64, P63, DOI 10.1016/j.jpsychores.2007.06.008
   Yao BC, 2019, J INT MED RES, V47, P1429, DOI 10.1177/0300060519826820
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
NR 57
TC 6
Z9 7
U1 0
U2 6
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD MAR
PY 2020
VL 17
IS 5
AR 1608
DI 10.3390/ijerph17051608
PG 14
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA KY2GJ
UT WOS:000522389200148
PM 32131511
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Al Sharif, M
   Vitcheva, V
   Simeonova, R
   Krasteva, I
   Manov, V
   Alov, P
   Popov, G
   Shkondrov, A
   Pajeva, I
AF Al Sharif, Merilin
   Vitcheva, Vessela
   Simeonova, Rumyana
   Krasteva, Ilina
   Manov, Vasil
   Alov, Petko
   Popov, Georgi
   Shkondrov, Aleksandar
   Pajeva, Ilza
TI In silico and in vivo studies of Astragalus
   glycyphylloides saponin(s) with relevance to metabolic syndrome
   modulation
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article; Proceedings Paper
CT 1st International Conference on Natural Toxicology and Pharmacology
   (ICNTP)
CY AUG 08-12, 2019
CL Guangzhou, PEOPLES R CHINA
SP Jinan Univ, Zhejiang Univ, Univ Macau, Univ Hong Kong, Int Assoc Dietet Nutr & Safety, Int Soc Chinese Med
DE Metabolic syndrome; Saponins; Metabolites; PPAR gamma;
   Pharmacophore-based docking; Diabetic spontaneously hypertensive rats
ID TRITERPENE SAPONINS; OLEANOLIC ACID; RAT; TOXICITY; PIOGLITAZONE;
   HYPERTENSION; AGONIST; TOOLS
AB Triterpenoids are well known modulators of metabolic syndrome. One of the suggested modes of action (MoAs) involves peroxisome proliferator-activated receptor gamma (PPAR gamma) binding.
   In this study we aimed to: (i) evaluate in silica potential metabolites and PPAR gamma-mediated MoA of the sapogenin of the main saponin present in a purified saponins' mixture (PSM) from Astragalus glycyphylloides; (ii) estimate in silica and in vivo PSM's toxicity; and (iii) investigate in vivo antihyperglycaemic, hypolipidaemic, antioxidant and hepatoprotective effects of PSM.
   Metabolites and toxicity were predicted using Meteor and Derek Nexus expert systems (Lhasa Limited) and PPAR gamma binding was investigated using the software MOE (CCG Inc.). PSM's acute oral toxicity was evaluated in mice and the pharmacological effects were assessed in streptozotocin-induced diabetic spontaneously hypertensive rats (SHRs). Liver histopathology was studied as well.
   PPAR gamma weak partial agonism was predicted in silico for 24 probable/plausible Phase I metabolites which docking poses were clustered in 12 different binding modes with characteristic protein-ligand interactions. PSM's beneficial effects on the levels of blood glucose, triglycerides, and total cholesterol, on oxidative stress markers and liver histology in diabetic SHRs were comparable to those of the PPAR gamma ligand pioglitazone. PSM's safety profile was confirmed in silico and in vivo.
C1 [Al Sharif, Merilin; Alov, Petko; Pajeva, Ilza] Bulgarian Acad Sci, Inst Biophys & Biomed Engn, Dept QSAR & Mol Modelling, Acad G Bonchev Str,Bl 105, BU-1113 Sofia, Bulgaria.
   [Vitcheva, Vessela; Simeonova, Rumyana] Med Univ Sofia, Fac Pharm, Dept Pharmacol Pharmacotherapy & Toxicol, Dunav 2 Str, Sofia 1000, Bulgaria.
   [Krasteva, Ilina; Shkondrov, Aleksandar] Med Univ Sofia, Fac Pharm, Dept Pharmacognosy, Dunav 2 Str, Sofia 1000, Bulgaria.
   [Manov, Vasil; Popov, Georgi] Univ Forestry Sofia, Fac Vet Med, Dept Internal Noncommunicable Dis Pathol & Pharma, 10 Kliment Ochridsky Blvd, Sofia 1756, Bulgaria.
C3 Bulgarian Academy of Sciences; Medical University Sofia; Medical
   University Sofia; University of Forestry - Bulgaria
RP Al Sharif, M (corresponding author), Bulgarian Acad Sci, Inst Biophys & Biomed Engn, Dept QSAR & Mol Modelling, Acad G Bonchev Str,Bl 105, BU-1113 Sofia, Bulgaria.
EM merilin.al@biomed.bas.bg; vesselavitcheva@yahoo.com;
   rvitanska@gmail.com; krasteva.ilina@abv.bg; vmanov@ltu.bg;
   petko@biophys.bas.bg; gpopov@ltu.bg; a_shkondrov@abv.bg;
   pajeva@biomed.bas.bg
RI Pajeva, Ilza/J-3242-2012; Popov, Georgi/LVR-9589-2024; Krasteva,
   Ilina/AFI-7757-2022; Simeonova, Rumyana/G-8002-2019; Shkondrov,
   Aleksandar/AER-5726-2022
OI Alov, Petko/0000-0003-1320-2173; Simeonova, Rumyana/0000-0003-4860-9053;
   Krasteva, Ilina/0000-0001-8559-0369; Shkondrov,
   Aleksandar/0000-0001-5091-6058
FU Bulgarian Ministry of Education and Science under the National Research
   Programme [577/17.08.2018]; National Science Fund of Bulgaria [DM
   01/1/2016]
FX Studies on prediction of Phase I metabolism and toxicity were supported
   by the Bulgarian Ministry of Education and Science under the National
   Research Programme "Healthy Foods for a Strong Bio-Economy and Quality
   of Life" approved by DCM # 577/17.08.2018; the molecular docking
   studies, part of the in vivo experiments and the pathohistological
   analysis were supported by the National Science Fund of Bulgaria (grant
   DM 01/1/2016).
CR Al Sharif M, 2018, FOOD CHEM TOXICOL, V112, P47, DOI 10.1016/j.fct.2017.12.009
   Al Sharif M, 2017, TOXICOL APPL PHARM, V337, P45, DOI 10.1016/j.taap.2017.10.013
   Alkhatib A, 2017, NUTRIENTS, V9, DOI 10.3390/nu9121310
   Andallu B, 2009, INT J DIABETES DEV C, V29, P123, DOI 10.4103/0973-3930.54289
   [Anonymous], 2013, INT J PHARM BIO SCI
   [Anonymous], EUR CONV PROT VERT A
   [Anonymous], 2013, MOL OP ENV MOE
   [Anonymous], GENETIC ANAL METABOL
   Asao Y, 2009, CHEM PHARM BULL, V57, P198, DOI 10.1248/cpb.57.198
   Brown L, 2015, OBES REV, V16, P914, DOI 10.1111/obr.12313
   Chan K. W., 2018, OXIDATIVE
   Chen MY, 2018, J PHARMACEUT BIOMED, V150, P199, DOI 10.1016/j.jpba.2017.12.011
   Chen Y, 2014, BMC COMPLEM ALTERN M, V14, DOI [10.1186/1472-6882-14-86, 10.1186/1471-2458-14-247]
   Cheung BMY, 2012, CURR ATHEROSCLER REP, V14, P160, DOI 10.1007/s11883-012-0227-2
   El-Mas MM, 2011, BIOCHEM PHARMACOL, V81, P526, DOI 10.1016/j.bcp.2010.11.013
   Erejuwa OO, 2011, INT J MOL SCI, V12, P1888, DOI 10.3390/ijms12031888
   Gamble J.B. M., 2008, THEORY PRACTICE HIST
   Gamede M, 2019, MOLECULES, V24, DOI 10.3390/molecules24020340
   Giacoman-Martínez A, 2019, PLANTA MED, V85, P412, DOI 10.1055/a-0824-1316
   Gong LL, 2016, J PHARMACOL EXP THER, V359, P392, DOI 10.1124/jpet.116.236562
   Haluzík M, 2000, PHYSIOL RES, V49, pS37
   Kawabata K, 2017, J NUTR SCI VITAMINOL, V63, P193, DOI 10.3177/jnsv.63.193
   Kim DH, 2018, J GINSENG RES, V42, P255, DOI 10.1016/j.jgr.2017.04.011
   Kondeva-Burdina M, 2013, BIOTECHNOL BIOTEC EQ, V27, P3866, DOI 10.5504/BBEQ.2013.0023
   Kuroda M, 2012, J NAT MED-TOKYO, V66, P394, DOI 10.1007/s11418-011-0593-z
   Langowski J, 2002, ADV DRUG DELIVER REV, V54, P407, DOI 10.1016/S0169-409X(02)00011-X
   Lee KT, 2000, ARCH PHARM RES, V23, P461, DOI 10.1007/BF02976573
   Liu J, 1995, J ETHNOPHARMACOL, V49, P57, DOI 10.1016/0378-8741(95)90032-2
   LORKE D, 1983, ARCH TOXICOL, V54, P275, DOI 10.1007/BF01234480
   Majithiya JB, 2005, CARDIOVASC RES, V66, P150, DOI 10.1016/j.cardiores.2004.12.025
   Marchant CA, 2008, TOXICOL MECH METHOD, V18, P177, DOI 10.1080/15376510701857320
   Montanari R, 2016, SCI REP-UK, V6, DOI 10.1038/srep27658
   Njuguna NM, 2012, J NAT PROD, V75, P507, DOI 10.1021/np200786j
   Petersen RK, 2011, J COMPUT AID MOL DES, V25, P107, DOI 10.1007/s10822-010-9398-5
   Polvani S, 2012, PPAR RES, V2012, DOI 10.1155/2012/641087
   Santana-Gálvez J, 2017, MOLECULES, V22, DOI 10.3390/molecules22030358
   Sharma H, 2018, PHYTOMEDICINE, V50, P166, DOI 10.1016/j.phymed.2018.09.011
   Shkondrov A, 2018, PHYTOCHEM LETT, V26, P44, DOI 10.1016/j.phytol.2018.05.015
   Sil R, 2015, MOL CELL BIOCHEM, V409, P177, DOI 10.1007/s11010-015-2523-y
   Simeonova R, 2016, PHYTOMEDICINE, V23, P483, DOI 10.1016/j.phymed.2016.02.024
   Quang TH, 2011, CARBOHYD RES, V346, P2567, DOI 10.1016/j.carres.2011.08.029
   Wang S, 2018, BIOMED PHARMACOTHER, V108, P1181, DOI 10.1016/j.biopha.2018.09.150
   Xu H, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20010128
   Yang B, 2018, FITOTERAPIA, V129, P210, DOI 10.1016/j.fitote.2018.07.005
NR 44
TC 1
Z9 1
U1 0
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD AUG
PY 2019
VL 130
BP 317
EP 325
DI 10.1016/j.fct.2019.05.032
PG 9
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Food Science & Technology; Toxicology
GA IE7XV
UT WOS:000472589200030
PM 31128217
DA 2025-06-11
ER

PT J
AU Almomen, SMK
   Guan, QN
   Liang, PH
   Yang, KD
   Sidiqi, AM
   Levin, A
   Du, CG
AF Almomen, Salwa M. K.
   Guan, Qiunong
   Liang, Peihe
   Yang, Kaidi
   Sidiqi, Ahmad M.
   Levin, Adeera
   Du, Caigan
TI Daily Intake of Grape Powder Prevents the Progression of Kidney Disease
   in Obese Type 2 Diabetic ZSF1 Rats
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; chronic kidney disease; grape powder; antioxidants;
   natural products; dietary supplements
ID LOW-PROTEIN DIET; OXIDATIVE STRESS; METABOLIC SYNDROME;
   HYDROGEN-PEROXIDE; RENAL-FUNCTION; SKIN EXTRACT; SEED; MECHANISMS;
   HEALTH; NEPHROPATHY
AB Individuals living with metabolic syndrome (MetS) such as diabetes and obesity are at high risk for developing chronic kidney disease (CKD). This study investigated the beneficial effect of whole grape powder (WGP) diet on MetS-associated CKD. Obese diabetic ZSF1 rats, a kidney disease model with MetS, were fed WGP (5%, w/w) diet for six months. Kidney disease was determined using blood and urine chemical analyses, and histology. When compared to Vehicle controls, WGP intake did not change the rat bodyweight, but lowered their kidney, liver and spleen weight, which were in parallel with the lower serum glucose and the higher albumin or albumin/globin ratio. More importantly, WGP intake improved the renal function as urination and proteinuria decreased, or it prevented kidney tissue damage in these diabetic rats. The renal protection of WGP diet was associated with up-regulation of antioxidants (Dhcr24, Gstk1, Prdx2, Sod2, Gpx1 and Gpx4) and downregulation of Txnip (for ROS production) in the kidneys. Furthermore, addition of grape extract reduced H2O2-induced cell death of cultured podocytes. In conclusion, daily intake of WGP reduces the progression of kidney disease in obese diabetic rats, suggesting a protective function of antioxidant-rich grape diet against CKD in the setting of MetS.
C1 [Almomen, Salwa M. K.; Guan, Qiunong; Liang, Peihe; Yang, Kaidi; Sidiqi, Ahmad M.; Du, Caigan] Univ British Columbia, Dept Urol Sci, Vancouver, BC V6H 3Z6, Canada.
   [Guan, Qiunong; Du, Caigan] Vancouver Coastal Hlth Res Inst, Immun & Infect Res Ctr, Vancouver, BC V6H 3Z6, Canada.
   [Liang, Peihe] Chongqing Med Univ, Affiliated Hosp 2, Dept Urol, Chongqing 400010, Peoples R China.
   [Sidiqi, Ahmad M.; Levin, Adeera] Univ British Columbia, Div Nephrol, Dept Med, Vancouver, BC V6Z 1Y6, Canada.
C3 University of British Columbia; Vancouver Coastal Health Research
   Institute; Chongqing Medical University; University of British Columbia
RP Du, CG (corresponding author), Univ British Columbia, Dept Urol Sci, Vancouver, BC V6H 3Z6, Canada.; Du, CG (corresponding author), Vancouver Coastal Hlth Res Inst, Immun & Infect Res Ctr, Vancouver, BC V6H 3Z6, Canada.
EM sa.momen@windowslive.com; qiunong@hotmail.com; lph1972@163.com;
   kaidiyang1994@gmail.com; ahmad.sidiqi@alumni.ubc.ca;
   alevin@providencehealth.bc.ca; caigan@mail.ubc
FU California Table Grape Commission (CA, USA); King Abdullah Scholarship
   Program of the Kingdom of Saudi Arabia; Second Affiliated Hospital of
   Chongqing Medical University; Canadian Mitacs Globalink Internship
FX This study was supported by a grant from the California Table Grape
   Commission (CA, USA); S.M.K.A. received the scholarship from King
   Abdullah Scholarship Program of the Kingdom of Saudi Arabia; P.L. the
   funding support from the Second Affiliated Hospital of Chongqing Medical
   University; and K.Y. the Canadian Mitacs Globalink Internship.
CR Ahloulay M, 1999, DIABETES METAB, V25, P213
   Ahmed S., 2012, AGE, V140, P13
   Aloui F, 2016, BIOMED PHARMACOTHER, V84, P2020, DOI 10.1016/j.biopha.2016.11.017
   Anderson CAM, 2016, MED CLIN N AM, V100, P1265, DOI 10.1016/j.mcna.2016.06.008
   Arici M., 2014, Management of Chronic Kidney Disease: A Clinician's Guide
   Arora P, 2013, CAN MED ASSOC J, V185, pE417, DOI 10.1503/cmaj.120833
   Babior BM, 1999, BLOOD, V93, P1464, DOI 10.1182/blood.V93.5.1464.405a32_1464_1476
   Baynes J, 2009, OXID MED CELL LONGEV, V2, P328, DOI 10.4161/oxim.2.5.9831
   Bernardi C, 1996, COMP HAEMATOL INT, V6, P160, DOI 10.1007/BF00368460
   Betteridge DJ, 2000, METABOLISM, V49, P3, DOI 10.1016/S0026-0495(00)80077-3
   Bilan VP, 2011, J ENDOCRINOL, V210, P293, DOI 10.1530/JOE-11-0122
   Birben E, 2012, WORLD ALLERGY ORGAN, V5, P9, DOI 10.1097/WOX.0b013e3182439613
   Brosius FC, 2014, ADV CHRONIC KIDNEY D, V21, P304, DOI 10.1053/j.ackd.2014.03.011
   Chan M, 2016, BMC NEPHROL, V17, DOI 10.1186/s12882-016-0341-4
   Coresh J, 2003, AM J KIDNEY DIS, V41, P1, DOI 10.1053/ajkd.2003.50007
   Du C., 2014, SYSTEMS BIOL FREE RA, P2606
   El-Mowafy AM, 2011, NAT PROD RES, V25, P850, DOI 10.1080/14786419.2010.533669
   Forman Henry Jay, 2001, Molecular Aspects of Medicine, V22, P189
   FREIREICH EMIL J., 1966, CANCER CHEMOTHERAP REP, V50, P219
   Griffin KA, 2007, AM J PHYSIOL-RENAL, V293, pF1605, DOI 10.1152/ajprenal.00511.2006
   Griffin SV, 2004, AM J PATHOL, V165, P1175, DOI 10.1016/S0002-9440(10)63378-0
   Johnson DW, 2004, INTERN MED J, V34, P50, DOI 10.1111/j.1444-0903.2004.t01-6-.x
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kowalska K, 2016, CURR OPIN CLIN NUTR, V19, P446, DOI 10.1097/MCO.0000000000000322
   LaGuardia HA, 2012, J NUTR METAB, V2012, DOI 10.1155/2012/652608
   Levey AS, 2012, LANCET, V379, P165, DOI 10.1016/S0140-6736(11)60178-5
   Levin A, 2008, CAN MED ASSOC J, V179, P1154, DOI 10.1503/cmaj.080351
   Li J, 2012, EUR J NUTR, V51, P961, DOI 10.1007/s00394-011-0274-4
   MOGENSEN CE, 1986, SCAND J CLIN LAB INV, V46, P201, DOI 10.3109/00365518609083660
   Nashar K, 2014, DIABET METAB SYND OB, V7, P421, DOI 10.2147/DMSO.S45183
   Newsholme P, 2016, BIOCHEM J, V473, P4527, DOI 10.1042/BCJ20160503C
   Novo E, 2008, FIBROGENESIS TISSUE, V1, DOI 10.1186/1755-1536-1-5
   Oueslati N, 2016, BIOMED PHARMACOTHER, V83, P584, DOI 10.1016/j.biopha.2016.07.024
   Pokkunuri I, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/6135319
   Prasad G V Ramesh, 2014, World J Nephrol, V3, P210, DOI 10.5527/wjn.v3.i4.210
   Rafikova O, 2008, METABOLISM, V57, P1434, DOI 10.1016/j.metabol.2008.05.014
   Rhee SG, 1999, EXP MOL MED, V31, P53, DOI 10.1038/emm.1999.9
   Rocha M, 2010, CURR PHARM DESIGN, V16, P3124, DOI 10.2174/138161210793292519
   Ross CF, 2011, J FOOD SCI, V76, pC884, DOI 10.1111/j.1750-3841.2011.02280.x
   Sadowska-Bartosz I, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/404680
   Sanchez-Gonzalez PD, 2011, NEPHROL DIAL TRANSPL, V26, P3484, DOI 10.1093/ndt/gfr195
   Shah BV, 2016, BMC NEPHROL, V17, DOI 10.1186/s12882-016-0360-1
   Singh AK, 2013, CURR OPIN NEPHROL HY, V22, P198, DOI 10.1097/MNH.0b013e32835dda78
   Spira A, 1997, AM J KIDNEY DIS, V30, P829, DOI 10.1016/S0272-6386(97)90089-5
   Stigant C, 2003, CAN MED ASSOC J, V168, P1553
   Sunny NE, 2017, TRENDS ENDOCRIN MET, V28, P250, DOI 10.1016/j.tem.2016.11.006
   Tanabe K, 2012, AM J PHYSIOL-RENAL, V303, pF1264, DOI 10.1152/ajprenal.00227.2012
   Thomas G, 2011, CLIN J AM SOC NEPHRO, V6, P2364, DOI 10.2215/CJN.02180311
   Tofovic SP, 2000, RENAL FAILURE, V22, P387, DOI 10.1081/JDI-100100882
   Tofovic SP, 2003, METH MOLEC MED, V86, P29
   Tofovic SP, 2001, RENAL FAILURE, V23, P159, DOI 10.1081/JDI-100103488
   Tofovic SP, 2007, RENAL FAILURE, V29, P891, DOI 10.1080/08860220701569846
   Turki K, 2016, EXCLI J, V15, P424, DOI 10.17179/excli2016-363
   Turkmen K., 2016, INT UROL NEPHROL, V49, P1
   Ullah A, 2016, SAUDI PHARM J, V24, P547, DOI 10.1016/j.jsps.2015.03.013
   Vassalotti JA, 2007, AM J KIDNEY DIS, V50, P169, DOI 10.1053/j.ajkd.2007.06.013
   Vendrame S, 2016, ANTIOXIDANTS-BASEL, V5, DOI 10.3390/antiox5040034
   Vora JP, 1996, J AM SOC NEPHROL, V7, P113
   Wang MJ, 2017, PANMINERVA MED, V59, P157, DOI 10.23736/S0031-0808.16.03264-X
   Williamson G, 1998, EUR J CANCER PREV, V7, P17
   Yang J, 2013, CRIT REV FOOD SCI, V53, P1202, DOI 10.1080/10408398.2012.692408
   Yilmaz Y, 2004, J AGR FOOD CHEM, V52, P255, DOI 10.1021/jf030117h
   Zhang XC, 2007, J CARDIOVASC PHARM, V49, P56, DOI 10.1097/FJC.0b013e31802cb88e
NR 63
TC 22
Z9 23
U1 0
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2017
VL 9
IS 4
AR 345
DI 10.3390/nu9040345
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EU9JI
UT WOS:000401355600030
PM 28362355
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Pastor, RF
   Repetto, MG
   Lairion, F
   Lazarowski, A
   Merelli, A
   Carabetti, ZM
   Pastor, I
   Pastor, E
   Iermoli, LV
   Bavasso, CA
   Iermoli, RH
AF Pastor, Raul Francisco
   Repetto, Marisa Gabriela
   Lairion, Fabiana
   Lazarowski, Alberto
   Merelli, Amalia
   Manfredi Carabetti, Zulma
   Pastor, Isabel
   Pastor, Elena
   Iermoli, Laura Valeria
   Bavasso, Carlos Amadeo
   Iermoli, Roberto Hector
TI Supplementation with Resveratrol, Piperine and Alpha-Tocopherol
   Decreases Chronic Inflammation in a Cluster of Older Adults with
   Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; chronic inflammation; resveratrol; piperine;
   alpha-tocopherol
ID C-REACTIVE PROTEIN; ADIPOSE-TISSUE; OBESITY; PREVENTION; PREVALENCE
AB Metabolic Syndrome (MetS) is increasing worldwide regardless of culture, genetic, gender, and geographic differences. While multiple individual risk factors, such as obesity, hypertension, diabetes, and hyperlipidemia, can cause cardiovascular disease (CVD), it is the intercurrence of these risk factors that defines MetS as a cluster that creates an environment for atherosclerosis and other manifestations of CVD. Despite the advances in the knowledge and management of each of the components of MetS, there are two molecular biology processes, chronic inflammation and oxidative stress, which are still underdiagnosed and undertreated. In order to assess the effect of a dietary supplement on chronic inflammation in MetS, we conducted a clinical trial with volunteers receiving a formula composed of resveratrol, piperine and alpha tocopherol (FRAMINTROL), together with their habitual treatment, for three months. The inflammatory state was evaluated by ultrasensitive C reactive protein (US CRP) and ferritin in plasma, and oxygen consumption and chemiluminescence in neutrophils. The results showed that ferritin decreased by 10% (p < 0.05), US-CRP by 33% (p < 0.0001), oxygen consumption by 55% (p < 0.0001), and spontaneous chemiluminiscence was by 25% (p < 0.005) after treatment. As far as we know, this is the first study showing a chronic inflammation decrease in MetS patients due to the administration of a biopower Resveratrol-piperine and alpha tocopherol dietary supplement together with conventional therapy.
C1 [Pastor, Raul Francisco; Manfredi Carabetti, Zulma; Pastor, Isabel; Pastor, Elena; Iermoli, Laura Valeria; Bavasso, Carlos Amadeo; Iermoli, Roberto Hector] Univ Buenos Aires, Hosp Clin Jose de San Martin, Fac Med, Unidad Polifenoles Vino & Salud,Cuarta Catedra Me, C1120AAF, Buenos Aires, DF, Argentina.
   [Repetto, Marisa Gabriela; Lairion, Fabiana] Univ Buenos Aires, Fac Farm & Bioquim, Dept Fisicoquim & Quim Analit, C1113AAD, Buenos Aires, DF, Argentina.
   [Repetto, Marisa Gabriela; Lairion, Fabiana] UBA, CONICET, Consejo Nacl Ciencia & Tecnol, Inst Bioquim & Med Mol IBIMOL, C1113AAD, Buenos Aires, DF, Argentina.
   [Lazarowski, Alberto; Merelli, Amalia] Univ Buenos Aires, Fac Farm & Bioquim, Dept Bioquim Clin, Inst Fisiopatol & Bioquim Clin INFIBIOC, C1113AAD, Buenos Aires, DF, Argentina.
C3 University of Buenos Aires; University of Buenos Aires Hospital;
   University of Buenos Aires; University of Buenos Aires; Consejo Nacional
   de Investigaciones Cientificas y Tecnicas (CONICET); University of
   Buenos Aires
RP Pastor, RF (corresponding author), Univ Buenos Aires, Hosp Clin Jose de San Martin, Fac Med, Unidad Polifenoles Vino & Salud,Cuarta Catedra Me, C1120AAF, Buenos Aires, DF, Argentina.
EM rpastor@fmed.uba.ar; mrepetto@ffyb.uba.ar; flairion@ffyb.uba.ar;
   nadiatom@ffyb.uba.ar; amerelli@ffyb.uba.ar;
   zulmamanfredi@tiempomedico.com.ar; ipastor@hospitaldeclinicas.uba.ar;
   epastor@hospitaldeclinicas.uba.ar; lauraiermoli@gmail.com;
   analisisintegrales@hotmail.com; riermoli@fmed.uba.ar
RI Pastor, Elena/L-2100-2014; Repetto, Marisa/R-5086-2016
OI Lazarowski, Alberto/0000-0001-8979-7631; Pastor, Raul
   Francisco/0000-0002-1722-8445
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Ansarimoghaddam A, 2018, DIABETES METAB SYND, V12, P195, DOI 10.1016/j.dsx.2017.11.004
   Biswas SK, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/5698931
   Bjelakovic G, 2007, JAMA-J AM MED ASSOC, V297, P842, DOI 10.1001/jama.297.8.842
   Bomfim GF, 2017, PHARMACOL RES, V117, P377, DOI 10.1016/j.phrs.2017.01.010
   Caillon A, 2019, BRIT J PHARMACOL, V176, P1818, DOI 10.1111/bph.14427
   CHANCE B, 1979, PHYSIOL REV, V59, P527, DOI 10.1152/physrev.1979.59.3.527
   Chen L, 2017, J DIABETES COMPLICAT, V31, P364, DOI 10.1016/j.jdiacomp.2016.06.018
   Chielle Eduardo O., 2018, J. Bras. Patol. Med. Lab., V54, P213, DOI 10.5935/1676-2444.20180037
   Chuchawankul S, 2012, GENET MOL RES, V11, P617, DOI 10.4238/2012.March.14.5
   Devaraj S, 2009, CURR OPIN LIPIDOL, V20, P182, DOI 10.1097/MOL.0b013e32832ac03e
   Devaraj S, 2009, CLIN CHEM, V55, P229, DOI 10.1373/clinchem.2008.108886
   Diaz A, 2018, HIPERTEN RIESGO VASC, V35, P64, DOI 10.1016/j.hipert.2017.08.003
   Suárez-Ortegón MF, 2018, ATHEROSCLEROSIS, V275, P97, DOI 10.1016/j.atherosclerosis.2018.05.043
   Haase J, 2014, DIABETOLOGIA, V57, P562, DOI 10.1007/s00125-013-3139-y
   Halliwell B, 2000, LANCET, V355, P1179, DOI 10.1016/S0140-6736(00)02075-4
   Halliwell B, 2013, BRIT J CLIN PHARMACO, V75, P637, DOI 10.1111/j.1365-2125.2012.04272.x
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Johnson JJ, 2011, MOL NUTR FOOD RES, V55, P1169, DOI 10.1002/mnfr.201100117
   Jukema RA, 2019, BMC MED, V17, DOI 10.1186/s12916-019-1433-3
   Kuhns Douglas B, 2015, Curr Protoc Immunol, V111, DOI 10.1002/0471142735.im0723s111
   Li R, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-2870-y
   Lumeng CN, 2011, J CLIN INVEST, V121, P2111, DOI 10.1172/JCI57132
   Márquez-Sandoval F, 2011, PUBLIC HEALTH NUTR, V14, P1702, DOI 10.1017/S1368980010003320
   Mikolajczyk TP, 2019, CURR HYPERTENS REP, V21, DOI 10.1007/s11906-019-0971-6
   Raciti GA, 2017, SCI REP-UK, V7, DOI 10.1038/srep43526
   Raposo L, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4471-9
   Reddy P, 2019, CLIN CHIM ACTA, V496, P35, DOI 10.1016/j.cca.2019.06.019
   Repetto M., 2008, HDB CHEMILUMINESCENT, V9, P163
   Repetto M, 2012, LIPID PEROXIDATION, P3, DOI 10.5772/45943
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sesso HD, 2008, JAMA-J AM MED ASSOC, V300, P2123, DOI 10.1001/jama.2008.600
   Shityakov S, 2019, EUR J MED CHEM, V176, P149, DOI 10.1016/j.ejmech.2019.04.002
   Sies H, 2017, ANNU REV BIOCHEM, V86, P715, DOI 10.1146/annurev-biochem-061516-045037
   Singh U, 2004, ANN NY ACAD SCI, V1031, P195, DOI 10.1196/annals.1331.019
   Skalicky J, 2008, CLIN CHEM LAB MED, V46, P499, DOI 10.1515/CCLM.2008.096
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Sun L, 2008, J CLIN ENDOCR METAB, V93, P4690, DOI 10.1210/jc.2008-1159
   Taverne YJ, 2018, BIOESSAYS, V40, DOI 10.1002/bies.201700158
   Valdez LB, 2001, ANTIOXID REDOX SIGN, V3, P505, DOI 10.1089/15230860152409130
   Vidigal FD, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-1198
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Zatterale F, 2020, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.01607
   Zhang SMM, 2008, JAMA-J AM MED ASSOC, V300, P2012, DOI 10.1001/jama.2008.555
NR 44
TC 14
Z9 16
U1 1
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2020
VL 12
IS 10
AR 3149
DI 10.3390/nu12103149
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OL3WN
UT WOS:000585274200001
PM 33076345
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tae, H
   Huh, H
   Hwang, J
   Chae, J
AF Tae, Hyejin
   Huh, Hyu Jung
   Hwang, Jihyun
   Chae, Jeong-Ho
TI Relationship between serum lipid concentrations and posttraumatic stress
   symptoms in the bereaved after the Sewol ferry disaster: A prospective
   cohort study
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE High-density lipoprotein cholesterol (HDL-C); Lipid; PTSD
ID MAJOR DEPRESSIVE DISORDER; HIGH-DENSITY-LIPOPROTEIN;
   CORONARY-ARTERY-DISEASE; MYOCARDIAL-INFARCTION; METABOLIC SYNDROME;
   CHOLESTEROL LEVELS; HEALTH BEHAVIORS; HDL-CHOLESTEROL; WAR VETERANS;
   RISK-FACTORS
AB The objective of this study was to investigate the relationship between serum lipid concentrations and PTSD symptoms in the bereaved after a traumatic familial loss. Eighteen months after the Sewol ferry disaster, 107 subjects who experienced traumatic losses as a result of the accident completed a mental and medical survey as well as laboratory tests for lipid profiles. At 30 months after the trauma, a total of 64 individuals completed a follow-up psychometric survey and biochemical measurements. We performed multiple linear regression analyses, examining the association between PTSD symptoms and lipid profiles. Other potential influences on lipid profiles such as metabolic risk factors, demographic risk factors, and underlying medical history were accounted for. Participants reporting clinically significant PTSD symptoms exhibited lower serum HDL-C levels than those without PTSD symptoms. In addition, we found that the severity of PTSD symptoms and sex could explain the changes in lipid profiles independently of other possible risk factors of changes. The results of this study suggest that PTSD symptoms may contribute to an increased risk for developing metabolic syndrome via detrimental changes in lipid concentrations. Routine screening and multidisciplinary management to prevent metabolic syndrome in individuals who experience traumatic losses would therefore be valuable.
C1 [Tae, Hyejin; Chae, Jeong-Ho] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Psychiat, 222 Banpo Daero, Seoul 06591, South Korea.
   [Huh, Hyu Jung] Catholic Univ Korea, Seoul St Marys Hosp, Hlth Promot Ctr, Stress Clin, Seoul, South Korea.
   [Hwang, Jihyun] Catholic Univ Korea, Catholic Biomed Ind Inst, Seoul, South Korea.
C3 Catholic University of Korea; Seoul St. Mary's Hospital; Seoul St.
   Mary's Hospital; Catholic University of Korea; Catholic University of
   Korea
RP Chae, J (corresponding author), Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Psychiat, 222 Banpo Daero, Seoul 06591, South Korea.
EM alberto@catholic.ac.kr
RI Tae, Hyejin/IXD-9804-2023
FU Korean Mental Health Technology R&D Project, Ministry of Health &
   Welfare, Republic of Korea [HM15C1054]
FX This study was supported by a grant of the Korean Mental Health
   Technology R&D Project, Ministry of Health & Welfare, Republic of
   Korea(HM15C1054).
CR Agargun MY, 2004, AM J PSYCHIAT, V161, P2121, DOI 10.1176/appi.ajp.161.11.2121
   Atmaca M, 2002, NEUROPSYCHOBIOLOGY, V45, P167, DOI 10.1159/000063665
   BAJWA WK, 1992, AM J PSYCHIAT, V149, P376
   Blevins CA, 2015, J TRAUMA STRESS, V28, P489, DOI 10.1002/jts.22059
   Boston PF, 1996, BRIT J PSYCHIAT, V169, P682, DOI 10.1192/bjp.169.6.682
   Bradley KA, 2003, ARCH INTERN MED, V163, P821, DOI 10.1001/archinte.163.7.821
   Bush K, 1998, ARCH INTERN MED, V158, P1789, DOI 10.1001/archinte.158.16.1789
   Carmassi C, 2015, PSYCHIAT RES, V225, P64, DOI 10.1016/j.psychres.2014.10.008
   Chapman MJ, 2010, EUR HEART J, V31, P149, DOI 10.1093/eurheartj/ehp399
   David D, 2004, PSYCHIAT SERV, V55, P82, DOI 10.1176/appi.ps.55.1.82
   Di Angelantonio E, 2009, JAMA-J AM MED ASSOC, V302, P1993, DOI 10.1001/jama.2009.1619
   Dortland AKBV, 2010, J CLIN PSYCHIAT, V71, P729, DOI 10.4088/JCP.08m04865blu
   Gander ML, 2006, EUR J CARDIOV PREV R, V13, P165, DOI 10.1097/01.hjr.0000214606.60995.46
   GARRISON RJ, 1978, ATHEROSCLEROSIS, V30, P17, DOI 10.1016/0021-9150(78)90149-1
   Godfrey KM, 2013, ANN GEN PSYCHIATR, V12, DOI 10.1186/1744-859X-12-30
   Graham I, 2007, EUR J CARDIOV PREV R, V14, pS1, DOI 10.1097/01.hjr.0000277983.23934.c9
   Grenier JL, 1997, CAN J PSYCHIAT, V42, P176, DOI 10.1177/070674379704200208
   Hamazaki K, 2014, EUR PSYCHIAT, V29, P408, DOI 10.1016/j.eurpsy.2014.05.002
   Hapke U, 2005, J NERV MENT DIS, V193, P843, DOI 10.1097/01.nmd.0000188964.83476.e0
   Hoge CW, 2014, LANCET PSYCHIAT, V1, P269, DOI 10.1016/S2215-0366(14)70235-4
   Jakovljevic M, 2008, PSYCHIAT DANUB, V20, P406
   Jakovljevic Miro, 2006, Psychiatr Danub, V18, P169
   Jakovljevic M, 2007, PSYCHIAT DANUB, V19, P270
   Jin H, 2009, J CLIN PSYCHOPHARM, V29, P210, DOI 10.1097/JCP.0b013e3181a45ed0
   JUDSON JJ, 1971, J AMER MED ASSOC, V216, P1185
   Kagan BL, 1999, BIOL PSYCHIAT, V45, P374, DOI 10.1016/S0006-3223(98)00059-6
   Kalman D, 2005, AM J ADDICTION, V14, P106, DOI 10.1080/10550490590924728
   Karlovic D, 2004, J KOREAN MED SCI, V19, P431, DOI 10.3346/jkms.2004.19.3.431
   Khadjesari Z, 2017, ADDICT SCI CLIN PRAC, V12, DOI 10.1186/s13722-016-0066-5
   Kjeldsen Sverre E., 1992, Journal of Cardiovascular Pharmacology, V20, pS32, DOI 10.1097/00005344-199220008-00008
   Kontush A, 2006, PHARMACOL REV, V58, P342, DOI 10.1124/pr.58.3.1
   Kulenovic AD, 2008, CROAT MED J, V49, P506, DOI 10.3325/cmj.2008.4.506
   Lehto SM, 2010, PSYCHIAT CLIN NEUROS, V64, P279, DOI 10.1111/j.1440-1819.2010.02079.x
   Maes M, 1997, ACTA PSYCHIAT SCAND, V95, P212, DOI 10.1111/j.1600-0447.1997.tb09622.x
   Maher MJ, 2006, CNS DRUGS, V20, P567, DOI 10.2165/00023210-200620070-00003
   Maia DB, 2008, J AFFECT DISORDERS, V107, P259, DOI 10.1016/j.jad.2007.08.013
   MCCANN BS, 1995, PSYCHOSOM MED, V57, P165, DOI 10.1097/00006842-199503000-00009
   Mendall MA, 1997, HEART, V78, P273, DOI 10.1136/hrt.78.3.273
   New AS, 1999, PSYCHIAT RES, V85, P145, DOI 10.1016/S0165-1781(99)00007-4
   Olusi SO, 1996, BIOL PSYCHIAT, V40, P1128, DOI 10.1016/S0006-3223(95)00599-4
   Parekh A, 2017, HEALTHCARE-BASEL, V5, DOI 10.3390/healthcare5010005
   Piché MÉ, 2005, AM J CARDIOL, V96, P92, DOI 10.1016/j.amjcard.2005.02.051
   QIZILBASH N, 1991, BRIT MED J, V303, P605, DOI 10.1136/bmj.303.6803.605
   Rabe-Jablonska J, 2000, Med Sci Monit, V6, P539
   Southwick SM, 1999, BIOL PSYCHIAT, V46, P1192, DOI 10.1016/S0006-3223(99)00219-X
   Thaller V, 1999, COLLEGIUM ANTROPOL, V23, P611
   Vieweg WVR, 2007, ACTA PSYCHIAT SCAND, V116, P483, DOI 10.1111/j.1600-0447.2007.01071.x
   Vilibic M, 2014, CROAT MED J, V55, P520, DOI 10.3325/cmj.2014.55.520
   Violanti John M, 2006, Int J Emerg Ment Health, V8, P227
   Von Känel R, 2010, WORLD J BIOL PSYCHIA, V11, P141, DOI 10.3109/15622970903449846
   WANG S, 1995, PSYCHOSOM MED, V57, P398, DOI 10.1097/00006842-199507000-00012
   YEHUDA R, 1992, J NERV MENT DIS, V180, P321, DOI 10.1097/00005053-199205000-00006
   Zen AL, 2012, HEALTH PSYCHOL, V31, P194, DOI 10.1037/a0025989
   Zohar J, 2008, CURR OPIN PSYCHIATR, V21, P74, DOI 10.1097/YCO.0b013e3282f269ee
NR 54
TC 8
Z9 8
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD AUG
PY 2018
VL 266
BP 132
EP 137
DI 10.1016/j.psychres.2018.04.058
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GM1IP
UT WOS:000437819700020
PM 29864612
DA 2025-06-11
ER

PT J
AU Radojkovic, J
   Sikanic, N
   Bukumiric, Z
   Tadic, M
   Kostic, N
   Babic, R
AF Radojkovic, Jana
   Sikanic, Natasa
   Bukumiric, Zoran
   Tadic, Marijana
   Kostic, Nada
   Babic, Rade
TI Improvement of Glycemic Control in Insulin-Dependent Diabetics with
   Depression by Concomitant Treatment with Antidepressants
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE Antidepressive Agents; Depression; Diabetes Mellitus, Type 2;
   Inflammation; Risk Factors; Serotonin Uptake Inhibitors
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; ATORVASTATIN 80 MG;
   DOUBLE-BLIND; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; COMPLETED
   TRIALS; RISK-FACTORS; ASSOCIATION; PREVALENCE
AB Background: It is still disputable whether negative effects of comorbid depression in diabetics can be diminished by successful treatment of depression. The primary aim of this study was to assess whether addition of antidepressants to existing insulin treatment would further improve glycemic control in these patients. A secondary objective was to assess whether such treatment impairs their lipid and inflammatory status.
   Material/Methods: Total of 192 patients with poorly controlled diabetes (defined as HbA1c >= 8%) in the absence of any uncontrolled medical condition entered the 6-month run-in phase with optimization of diabetic therapy. Depression status was screened at the end of this phase by BDI-II depression testing. Patients with BDI-II 3 14 and psychiatric confirmation of depression (58 patients) entered the 6-month interventional phase with SSRI class antidepressants.
   Results: Fifty patients completed the study. During the run-in phase, HbA1c dropped from 10.0 +/- 1.8% to 8.5 +/- 1.2% (p<0.001), and during the interventional phase it dropped from 8.5 +/- 1.2% to 7.7 +/- 0.7% (p<0.001). BDI-II scores improved significantly from 30.4 +/- 13.2 to 23.5 +/- 11.0 (p=0.02) during the interventional phase. A positive linear correlation between improvement in depression scale and improvement in glycemic control was observed (R-2=0.139, p=0.008). Lipid profile and inflammatory status did not change significantly during the interventional phase.
   Conclusions: Patients with poorly controlled diabetes and comorbid depression might benefit from screening and treatment of depression with SSRI antidepressants by achieving an incremental effect on glycoregulation. This therapy did not have any adverse effects on lipid profile or inflammatory status.
C1 [Radojkovic, Jana; Kostic, Nada] Clin Ctr Dr Dragisa Misovic, Dept Clin Endocrinol, Belgrade, Serbia.
   [Sikanic, Natasa] Clin Ctr Dr Dragisa Misovic, Dept Clin Psychiat, Belgrade, Serbia.
   [Bukumiric, Zoran] Univ Belgrade, Univ Sch Med, Dept Med Stat, Belgrade, Serbia.
   [Tadic, Marijana; Kostic, Nada; Babic, Rade] Univ Belgrade, Univ Sch Med, Dept Internal Med, Belgrade, Serbia.
C3 University of Belgrade; University of Belgrade
RP Babic, R (corresponding author), Univ Belgrade, Univ Sch Med, Dept Internal Med, Belgrade, Serbia.
EM drbabic@gmail.com
RI ; Babic, Rade/AAO-1507-2020
OI Bukumiric, Zoran/0000-0002-7609-4504; Babic, Rade/0000-0002-1674-9732
CR Almeida OP, 2016, MATURITAS, V86, P3, DOI 10.1016/j.maturitas.2016.01.003
   Alsheikh-Ali AA, 2005, CIRCULATION, V111, P3051, DOI 10.1161/CIRCULATIONAHA.105.555482
   Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
   Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   Barakat Lolwa, 2013, ISRN Pharmacol, V2013, P146579, DOI 10.1155/2013/146579
   Baumeister H, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008381.pub2
   Beck A., 1996, Manual for the Beck Depression Inventory-II, P82, DOI DOI 10.1037/T00742-000
   Black SA, 2003, DIABETES CARE, V26, P2822, DOI 10.2337/diacare.26.10.2822
   Chen GY, 2015, MED SCI MONITOR, V21, P2476, DOI 10.12659/MSM.894246
   Clouse RE, 2003, PSYCHOSOM MED, V65, P376, DOI 10.1097/01.PSY.0000041624.96580.1F
   Colhoun HM, 2004, LANCET, V364, P685, DOI 10.1016/S0140-6736(04)16895-5
   Colin A, 2003, ENCEPHALE, V29, P49
   De Berardis D, 2010, INT J IMMUNOPATH PH, V23, P417, DOI 10.1177/039463201002300204
   De Berardis Domenico, 2012, ISRN Psychiatry, V2012, P387901, DOI 10.5402/2012/387901
   de Groot M, 2001, PSYCHOSOM MED, V63, P619, DOI 10.1097/00006842-200107000-00015
   Dhavale H S, 2013, J Assoc Physicians India, V61, P896
   Echeverry D, 2009, DIABETES CARE, V32, P2156, DOI 10.2337/dc09-0785
   Egede LE, 2005, DIABETES CARE, V28, P1339, DOI 10.2337/diacare.28.6.1339
   Egede LE, 2008, DIABETES TECHNOL THE, V10, P213, DOI 10.1089/dia.2007.0278
   Egede LE, 2010, DIABETES RES CLIN PR, V87, P302, DOI 10.1016/j.diabres.2010.01.024
   Fisar Z, 2005, GEN PHYSIOL BIOPHYS, V24, P221
   Golden SH, 2008, JAMA-J AM MED ASSOC, V299, P2751, DOI 10.1001/jama.299.23.2751
   Goldstein DE, 2004, DIABETES CARE, V27, P1761, DOI 10.2337/diacare.27.7.1761
   Gonzalez JS, 2008, DIABETES CARE, V31, P2398, DOI 10.2337/dc08-1341
   Jones P, 1998, AM J CARDIOL, V81, P582, DOI 10.1016/S0002-9149(97)00965-X
   Jones PH, 2003, AM J CARDIOL, V92, P152, DOI 10.1016/S0002-9149(03)00530-7
   Kent Steven M, 2003, Am Heart J, V145, pe8, DOI 10.1067/mhj.2003.34
   Kim GM, 2015, INT J PSYCHIAT MED, V50, P131, DOI 10.1177/0091217415605024
   Koponen H, 2015, BMC PSYCHIATRY, V15, DOI 10.1186/s12888-015-0567-x
   Laimer M, 2006, J CLIN PSYCHIAT, V67, P421, DOI 10.4088/JCP.v67n0313
   Lustman PJ, 2006, ARCH GEN PSYCHIAT, V63, P521, DOI 10.1001/archpsyc.63.5.521
   Lustman PJ, 1997, PSYCHOSOM MED, V59, P241, DOI 10.1097/00006842-199705000-00007
   Lustman PJ, 2000, DIABETES CARE, V23, P934, DOI 10.2337/diacare.23.7.934
   Lustman PJ, 2000, DIABETES CARE, V23, P618, DOI 10.2337/diacare.23.5.618
   Mancia G, 2013, EUR HEART J, V34, P2159, DOI 10.1093/eurheartj/eht151
   Manfredini R, 2000, J INT MED RES, V28, P247, DOI 10.1177/147323000002800601
   Masuda Y, 2000, METHOD FIND EXP CLIN, V22, P667, DOI 10.1358/mf.2000.22.9.802281
   McIntyre RS, 2010, CNS DRUGS, V24, P741, DOI 10.2165/11533280-000000000-00000
   Menke A, 2015, JAMA-J AM MED ASSOC, V314, P1021, DOI 10.1001/jama.2015.10029
   Mikaliukstiene A, 2014, MED SCI MONITOR, V20, P182, DOI 10.12659/MSM.890019
   Newman C, 2006, AM J CARDIOL, V97, P61, DOI 10.1016/j.amjcard.2005.07.108
   Newman CB, 2003, AM J CARDIOL, V92, P670, DOI 10.1016/S0002-9149(03)00820-8
   Nicholas LM, 2003, J CLIN PSYCHIAT, V64, P883, DOI 10.4088/JCP.v64n0805
   Nicolau J, 2013, DIABETES RES CLIN PR, V101, P148, DOI 10.1016/j.diabres.2013.05.009
   Nissen SE, 2004, JAMA-J AM MED ASSOC, V291, P1071, DOI 10.1001/jama.291.9.1071
   O'Brien SM, 2006, BRIT J PSYCHIAT, V188, P449, DOI 10.1192/bjp.bp.105.011015
   Okamura F, 2000, METABOLISM, V49, P1255, DOI 10.1053/meta.2000.9515
   Papelbaum M, 2011, DIABETOL METAB SYNDR, V3, DOI 10.1186/1758-5996-3-26
   Petrak F, 2015, DIABETES CARE, V38, P767, DOI 10.2337/dc14-1599
   Reiner Z, 2011, EUR HEART J, V32, P1769, DOI [10.1016/j.atherosclerosis.2011.06.012, 10.1093/eurheartj/ehr158]
   Richardson LK, 2008, GEN HOSP PSYCHIAT, V30, P509, DOI 10.1016/j.genhosppsych.2008.07.001
   Ridker PM, 2005, J AM COLL CARDIOL, V45, P1644, DOI 10.1016/j.jacc.2005.02.080
   Roberts AL, 2015, JAMA PSYCHIAT, V72, P203, DOI 10.1001/jamapsychiatry.2014.2632
   Rydén L, 2013, EUR HEART J, V34, P3035, DOI 10.1093/eurheartj/eht108
   Simon GE, 2005, GEN HOSP PSYCHIAT, V27, P344, DOI 10.1016/j.genhosppsych.2005.04.008
   Smarr KL, 2011, ARTHRIT CARE RES, V63, pS454, DOI 10.1002/acr.20556
   Stanojevic A, 2013, SRP ARK CELOK LEK, V141, P511, DOI 10.2298/SARH1308511S
   Suarez EC, 2004, PSYCHOSOM MED, V66, P684, DOI 10.1097/01.psy.0000138281.73634.67
   SURWIT RS, 1993, PSYCHOSOM MED, V55, P380, DOI 10.1097/00006842-199307000-00005
   van de Ree MA, 2003, ATHEROSCLEROSIS, V166, P129, DOI 10.1016/S0021-9150(02)00316-7
   van Wissen S, 2002, ATHEROSCLEROSIS, V165, P361, DOI 10.1016/S0021-9150(02)00280-0
   Wiltink J, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0105499
   World Med Assoc, 2013, JAMA-J AM MED ASSOC, V310, P2191, DOI 10.1001/jama.2013.281053
   Yang CC, 2003, ARCH INTERN MED, V163, P1926, DOI 10.1001/archinte.163.16.1926
   Zhang XP, 2005, AM J EPIDEMIOL, V161, P652, DOI 10.1093/aje/kwi089
NR 65
TC 7
Z9 9
U1 0
U2 14
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
EI 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD JUN 22
PY 2016
VL 22
BP 2133
EP 2143
DI 10.12659/MSM.899571
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DP1JR
UT WOS:000378246800001
PM 27329213
OA Green Published
DA 2025-06-11
ER

PT J
AU Zulhendri, F
   Ravalia, M
   Kripal, K
   Chandrasekaran, K
   Fearnley, J
   Perera, CO
AF Zulhendri, Felix
   Ravalia, Munir
   Kripal, Krishna
   Chandrasekaran, Kavita
   Fearnley, James
   Perera, Conrad O.
TI Propolis in Metabolic Syndrome and Its Associated Chronic Diseases: A
   Narrative Review
SO ANTIOXIDANTS
LA English
DT Review
DE propolis; metabolic syndrome; antioxidant; anti-inflammation; chronic
   diseases; cardiovascular; diabetes mellitus; chronic kidney disease;
   fatty liver disease; Alzheimer&#8217; s disease
ID IMPROVES INSULIN SENSITIVITY; STINGLESS BEE PROPOLIS; ACID PHENETHYL
   ESTER; DOUBLE-BLIND; ANTIOXIDANT ACTIVITY; REMNANT CHOLESTEROL;
   OXIDATIVE STRESS; GREEN PROPOLIS; BLOOD-PRESSURE; RISK
AB Propolis is a resinous product collected by bees from plants to protect and maintain the homeostasis of their hives. Propolis has been used therapeutically by humans for centuries. This review article attempts to analyze the potential use of propolis in metabolic syndrome (MetS) and its associated chronic diseases. MetS and its chronic diseases were shown to be involved in at least seven out of the top 10 causes of death in 2019. Patients with MetS are also at a heightened risk of severe morbidity and mortality in the present COVID-19 pandemic. Propolis with its antioxidant and anti-inflammatory properties is potentially useful in ameliorating the symptoms of MetS and its associated chronic diseases. The aim of this article is to provide a comprehensive review on propolis and its therapeutic benefit in MetS and its chronic diseases, with an emphasis on in vitro and in vivo studies, as well as human clinical trials. Moreover, the molecular and biochemical mechanisms of action of propolis are also discussed. Propolis inhibits the development and manifestation of MetS and its chronic diseases by inhibiting of the expression and interaction of advanced glycation end products (AGEs) and their receptors (RAGEs), inhibiting pro-inflammatory signaling cascades, and promoting the cellular antioxidant systems.
C1 [Zulhendri, Felix] Kebun Efi, North Sumatra 2217, Indonesia.
   [Ravalia, Munir] Royal London Hosp, Whitechapel Rd, London E1 1FR, England.
   [Kripal, Krishna] Rajarajeswari Dent Coll & Hosp, 14 Ramohalli Cross,Mysore Rd, Bengaluru 560074, Karnataka, India.
   [Chandrasekaran, Kavita] Peerzadiguda, Hyderabad 500039, Telangana, India.
   [Fearnley, James] Apiceut Res Ctr, Unit 3b Enterprise Way, Whitby YO18 7NA, N Yorkshire, England.
   [Perera, Conrad O.] Univ Auckland, Sch Chem Sci, Food Sci Program, 23 Symonds St, Auckland 1010, New Zealand.
C3 Barts Health NHS Trust; Royal London Hospital; University of Auckland
RP Zulhendri, F (corresponding author), Kebun Efi, North Sumatra 2217, Indonesia.; Ravalia, M (corresponding author), Royal London Hosp, Whitechapel Rd, London E1 1FR, England.; Perera, CO (corresponding author), Univ Auckland, Sch Chem Sci, Food Sci Program, 23 Symonds St, Auckland 1010, New Zealand.
EM felix.zulhendri@gmail.com; munirrav@yahoo.co.uk;
   kripalkrishna@yahoo.com; dr.ckavita@gmail.com;
   james.fearnley@beearc.com; conradperera@gmail.com
RI Chandrasekaran, Kavita/AAE-9973-2021
OI Zulhendri, Felix/0000-0002-7881-1845; Perera,
   Conrad/0000-0001-9525-6962; CHANDRASEKARAN, DR.
   KAVITA/0000-0002-6259-5607
FU Kebun Efi
FX This research received no external funding and the APC was funded by
   Kebun Efi.
CR Abbasi A, 2015, FRONT MOL NEUROSCI, V8, DOI 10.3389/fnmol.2015.00021
   Abo-Salem OM, 2009, PAK J PHARM SCI, V22, P205
   Affuso F, 2012, WORLD J CARDIOL, V4, P77, DOI 10.4330/wjc.v4.i3.77
   Aggarwal BB, 2010, ANNU REV NUTR, V30, P173, DOI 10.1146/annurev.nutr.012809.104755
   Ahn MR, 2007, FOOD CHEM, V101, P1383, DOI 10.1016/j.foodchem.2006.03.045
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Aldahmash BA, 2016, NEFROLOGIA, V36, P643, DOI 10.1016/j.nefro.2016.06.004
   Alizadeh S, 2019, ARCH ENDOCRIN METAB, V63, P427, DOI 10.20945/2359-3997000000149
   Amalia E, 2020, ONCOL LETT, V20, DOI 10.3892/ol.2020.12137
   Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
   Amiot MJ, 2016, OBES REV, V17, P573, DOI 10.1111/obr.12409
   [Anonymous], 2012, GASTROENTEROLOGY, V142, P1592, DOI [DOI 10.1053/J.GASTRO.2012.04.001, 10.1053/j.gastro.2012.04.001]
   [Anonymous], 2020, Statista
   Antonio Meraz-Rios M., 2020, NEURODEGENERATIVE DI
   Aoi W, 2013, BIOCHEM BIOPH RES CO, V432, P650, DOI 10.1016/j.bbrc.2013.02.029
   Aragno M, 2009, FREE RADICAL BIO MED, V47, P1067, DOI 10.1016/j.freeradbiomed.2009.07.016
   Babatunde IR, 2015, J INTERCULT ETHNOPHA, V4, P102, DOI 10.5455/jice.20150202023615
   Bae Y, 2011, TOXICOL APPL PHARM, V254, P56, DOI 10.1016/j.taap.2011.04.008
   Balling M, 2020, J AM COLL CARDIOL, V76, P2725, DOI 10.1016/j.jacc.2020.09.610
   Bassi N, 2014, AM J MED, V127, DOI 10.1016/j.amjmed.2014.06.035
   Baykara M, 2015, DIAGN INTERV RADIOL, V21, P317, DOI 10.5152/dir.2015.14075
   Bazmandegan G, 2017, BIOMED PHARMACOTHER, V85, P503, DOI 10.1016/j.biopha.2016.11.057
   da Costa MFB, 2015, PHYTOMEDICINE, V22, P787, DOI 10.1016/j.phymed.2015.03.017
   Bhadauria M, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/235358
   Boden-Albala B, 2008, STROKE, V39, P30, DOI 10.1161/STROKEAHA.107.496588
   Boisard S, 2020, INT J FOOD SCI TECH, V55, P453, DOI 10.1111/ijfs.14284
   Boisard S, 2014, J AGR FOOD CHEM, V62, P1344, DOI 10.1021/jf4053397
   Borba RS, 2015, J EXP BIOL, V218, P3689, DOI 10.1242/jeb.127324
   Borshchev YY, 2019, LIFE SCI, V237, DOI 10.1016/j.lfs.2019.116932
   Boutabet K, 2011, Indian J Nephrol, V21, P101, DOI 10.4103/0971-4065.82131
   Cameron AJ, 2008, J INTERN MED, V264, P177, DOI 10.1111/j.1365-2796.2008.01935.x
   Castañer O, 2020, J AM COLL CARDIOL, V76, P2712, DOI 10.1016/j.jacc.2020.10.008
   Catrysse L, 2017, TRENDS CELL BIOL, V27, P417, DOI 10.1016/j.tcb.2017.01.006
   Chang JF, 2020, TOXINS, V12, DOI 10.3390/toxins12060364
   Chen HY, 2021, GUT, V70, P1147, DOI 10.1136/gutjnl-2020-321661
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Chen LH, 2018, NUTRIENTS, V10, DOI 10.3390/nu10040503
   Ching-Ha Kwan B, 2006, Minerva Urol Nefrol, V58, P1
   Claus Ralf, 2000, Arzneimittel-Forschung, V50, P373
   Coletta DK, 2011, AM J PHYSIOL-ENDOC M, V301, pE749, DOI 10.1152/ajpendo.00363.2011
   Coughlan MT, 2011, DIABETES, V60, P2523, DOI 10.2337/db10-1033
   Cuevas A, 2014, ARCH BIOCHEM BIOPHYS, V557, P28, DOI 10.1016/j.abb.2014.04.009
   Czaja MJ, 2010, TRENDS ENDOCRIN MET, V21, P707, DOI 10.1016/j.tem.2010.08.010
   Dalenberg H, 2020, INSECTS, V11, DOI 10.3390/insects11070453
   Daleprane JB, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/175135
   Danaei G, 2009, PLOS MED, V6, DOI 10.1371/journal.pmed.1000058
   Davì G, 2010, CARDIOVASC THER, V28, P216, DOI 10.1111/j.1755-5922.2010.00179.x
   Rodrigues MED, 2019, ALZHEIMERS RES THER, V12, DOI 10.1186/s13195-019-0546-4
   DEFRONZO RA, 1991, DIABETES CARE, V14, P173, DOI 10.2337/diacare.14.3.173
   Dezmirean DS, 2021, PLANTS-BASEL, V10, DOI 10.3390/plants10010022
   Dietz W, 2020, OBESITY, V28, P1005, DOI 10.1002/oby.22818
   Silveira MAD, 2019, BMC NEPHROL, V20, DOI 10.1186/s12882-019-1337-7
   Eckardt KU, 2013, LANCET, V382, P158, DOI 10.1016/S0140-6736(13)60439-0
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Ekstedt M, 2006, HEPATOLOGY, V44, P865, DOI 10.1002/hep.21327
   El-Sharkawy HM, 2016, J PERIODONTOL, V87, P1418, DOI 10.1902/jop.2016.150694
   Ercan Nuray, 2015, Eur J Dent, V9, P272, DOI 10.4103/1305-7456.156851
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   Fang YQ, 2013, LIPIDS HEALTH DIS, V12, DOI 10.1186/1476-511X-12-123
   Fikri A, 2019, J APIC SCI, V63, P139, DOI [10.2478/JAS-2019-0012, 10.2478/jas-2019-0012]
   Fiorini AC, 2021, CLINICS, V76, DOI 10.6061/clinics/2021/e2357
   Foglia B, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20112700
   Ford ES, 2008, DIABETES CARE, V31, P1898, DOI 10.2337/dc08-0423
   Forouzanfar MH, 2016, LANCET, V388, P1659, DOI 10.1016/S0140-6736(16)31679-8
   Frisardi V, 2010, AGEING RES REV, V9, P399, DOI 10.1016/j.arr.2010.04.007
   Fu SH, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00502
   Fukuda T, 2015, BIOMED REP, V3, P355, DOI 10.3892/br.2015.436
   Fuliang HU, 2005, PHARMACOL RES, V51, P147, DOI 10.1016/j.phrs.2004.06.011
   Funakoshi-Tago M, 2015, INT IMMUNOPHARMACOL, V25, P189, DOI 10.1016/j.intimp.2015.01.012
   GALIS ZS, 1994, J CLIN INVEST, V94, P2493, DOI 10.1172/JCI117619
   Gao WN, 2018, DIABETES THER, V9, P101, DOI 10.1007/s13300-017-0341-9
   GHISALBERTI EL, 1979, BEE WORLD, V60, P59, DOI 10.1080/0005772X.1979.11097738
   Gogebakan A, 2012, CLIN EXP HYPERTENS, V34, P424, DOI 10.3109/10641963.2012.665542
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Ha SK, 2010, NEUROSCI LETT, V485, P143, DOI 10.1016/j.neulet.2010.08.064
   Hao RL, 2020, FOOD CHEM TOXICOL, V144, DOI 10.1016/j.fct.2020.111636
   Henao-Mejia J, 2012, NATURE, V482, P179, DOI 10.1038/nature10809
   Hesami S, 2019, CASP J INTERN MED, V10, P48, DOI 10.22088/cjim.10.1.48
   Hori Juliana I, 2013, Evid Based Complement Alternat Med, V2013, P418508, DOI 10.1155/2013/418508
   Hotta S, 2020, BIOSCI BIOTECH BIOCH, V84, P1820, DOI 10.1080/09168451.2020.1773756
   Hsieh CY, 2019, J CELL PHYSIOL, V234, P4081, DOI 10.1002/jcp.27204
   Huttunen HJ, 1999, J BIOL CHEM, V274, P19919, DOI 10.1074/jbc.274.28.19919
   Ibrahim N., 2016, Int. J. Pharmacogn. Phytochem. Res, V8, P156
   Ikeda R, 2011, BBA-GEN SUBJECTS, V1810, P695, DOI 10.1016/j.bbagen.2011.04.007
   Inoue M, 1998, CIRCULATION, V98, P2108, DOI 10.1161/01.CIR.98.20.2108
   Iqbal SP, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0224054
   Isakov VA, 2018, NUTRIENTS, V10, DOI 10.3390/nu10020120
   Izzularab BM, 2021, ENVIRON TOXICOL, V36, P55, DOI 10.1002/tox.23010
   Jalali M, 2020, COMPLEMENT THER MED, V50, DOI 10.1016/j.ctim.2020.102380
   Jin XL, 2017, J FUNCT FOODS, V34, P216, DOI 10.1016/j.jff.2017.04.039
   Joshi Praphul, 2020, International Journal of Business Excellence, V21, P429
   Kazemi F, 2019, COLLOID SURFACE B, V177, P188, DOI 10.1016/j.colsurfb.2019.01.046
   Kearney PM, 2004, J HYPERTENS, V22, P11, DOI 10.1097/00004872-200401000-00003
   Kim SW, 2020, BIOCHEM PHARMACOL, V175, DOI 10.1016/j.bcp.2020.113866
   Kismet K, 2017, BIOMED PHARMACOTHER, V90, P863, DOI 10.1016/j.biopha.2017.04.062
   Kitamura H, 2013, ADIPOCYTE, V2, P227, DOI 10.4161/adip.25608
   Kumazawa S, 2004, FOOD CHEM, V84, P329, DOI 10.1016/S0308-8146(03)00216-4
   Kuropatnicki Andrzej K, 2013, Evid Based Complement Alternat Med, V2013, P964149, DOI 10.1155/2013/964149
   Lee Yu Ho, 2016, Electrolyte Blood Press, V14, P21, DOI 10.5049/EBP.2016.14.2.21
   Li YJ, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/981896
   Li ZP, 2019, BRAIN BEHAV IMMUN, V79, P228, DOI 10.1016/j.bbi.2019.02.005
   Libby P, 2002, NATURE, V420, P868, DOI 10.1161/ATVBAHA.108.179705
   Liu M, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00826
   Liu R, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-105
   Lu B, 2014, Handb Exp Pharmacol, V220, P223, DOI 10.1007/978-3-642-45106-5_9
   Luque-Contreras D, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/497802
   Malekmohammad K, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9080301
   Mao W, 2013, P NATL ACAD SCI USA, V110, P8842, DOI 10.1073/pnas.1303884110
   Marchio P, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8563845
   Márquez N, 2004, J PHARMACOL EXP THER, V308, P993, DOI 10.1124/jpet.103.060673
   Maruyama H, 2009, BIOL PHARM BULL, V32, P1244, DOI 10.1248/bpb.32.1244
   Matsushige K, 1996, PHYTOMEDICINE, V3, P203, DOI 10.1016/S0944-7113(96)80037-7
   Matsushita K, 2006, ARTERIOSCL THROM VAS, V26, P871, DOI 10.1161/01.ATV.0000208363.85388.8f
   Mauvais-Jarvis F, 2020, DIABETES, V69, P1857, DOI 10.2337/dbi19-0023
   McGurnaghan SJ, 2021, LANCET DIABETES ENDO, V9, P82, DOI 10.1016/S2213-8587(20)30405-8
   Meager A, 1999, CYTOKINE GROWTH F R, V10, P27, DOI 10.1016/S1359-6101(98)00024-0
   Mercurio V, 2015, VASC PHARMACOL, V75, P63, DOI 10.1016/j.vph.2015.11.053
   Minatohara K, 2016, FRONT MOL NEUROSCI, V8, DOI 10.3389/fnmol.2015.00078
   Minter MR, 2016, J NEUROCHEM, V136, P457, DOI 10.1111/jnc.13411
   Mishima S, 2005, BIOL PHARM BULL, V28, P1909, DOI 10.1248/bpb.28.1909
   Morrison JA, 2008, J PEDIATR-US, V152, P201, DOI 10.1016/j.jpeds.2007.09.010
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Mujica V, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/4272940
   Mulyati AH, 2020, AIP CONF PROC, V2243, DOI 10.1063/5.0005567
   Muzica CM, 2020, CAN J GASTROENTEROL, V2020, DOI 10.1155/2020/6638306
   Nanaware S, 2017, BIOMED PHARMACOTHER, V93, P543, DOI 10.1016/j.biopha.2017.06.072
   Natarajan K, 1996, P NATL ACAD SCI USA, V93, P9090, DOI 10.1073/pnas.93.17.9090
   Nguyen MT, 2019, J CLIN MED, V8, DOI 10.3390/jcm8081109
   Ni JJ, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/7984327
   Niu GD, 2011, APIDOLOGIE, V42, P79, DOI 10.1051/apido/2010039
   Nna VU, 2018, LIFE SCI, V211, P40, DOI 10.1016/j.lfs.2018.09.018
   Nogueira-Machado JA, 2008, EXPERT OPIN THER TAR, V12, P871, DOI [10.1517/14728222.12.7.871, 10.1517/14728222.12.7.871 ]
   Volpe CMO, 2018, CELL DEATH DIS, V9, DOI 10.1038/s41419-017-0135-z
   Orsolic Nada, 2012, BMC Complement Altern Med, V12, P117, DOI 10.1186/1472-6882-12-117
   Pahwa R, 2021, DIABETES-METAB RES, V37, DOI 10.1002/dmrr.3383
   Pai SA, 2019, N-S ARCH PHARMACOL, V392, P1617, DOI 10.1007/s00210-019-01705-3
   Park YK, 2002, J AGR FOOD CHEM, V50, P2502, DOI 10.1021/jf011432b
   Pasinetti GM, 2008, J NEUROCHEM, V106, P1503, DOI 10.1111/j.1471-4159.2008.05454.x
   Paulino N, 2008, EUR J PHARMACOL, V587, P296, DOI 10.1016/j.ejphar.2008.02.067
   Pazin WM, 2017, J APICULT RES, V56, P40, DOI 10.1080/00218839.2016.1263496
   Pfluecke C, 2013, J AM COLL CARDIOL, V61, pE1829, DOI 10.1016/S0735-1097(13)61829-X
   Pujirahayu N, 2019, PLANTS-BASEL, V8, DOI 10.3390/plants8030057
   Qiu Y, 2019, ANN NUTR METAB, V75, P168, DOI 10.1159/000504356
   Raffaitin C, 2009, DIABETES CARE, V32, P169, DOI 10.2337/dc08-0272
   Reaven G.M, 1992, MULTIPLE RISK FACTOR, P91
   Refaat H, 2021, INT J PHARMACEUT, V592, DOI 10.1016/j.ijpharm.2020.120028
   Neto MSR, 2017, FOOD CHEM TOXICOL, V107, P572, DOI 10.1016/j.fct.2017.03.052
   Rivera-Yañez N, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010078
   Rivera-Yanez Nelly, 2018, Evid Based Complement Alternat Med, V2018, P4360356, DOI 10.1155/2018/4360356
   Rojas-Gutierrez E, 2017, SYNAPSE, V71, DOI 10.1002/syn.21990
   Rosanoff A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010195
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Russo A, 2002, FITOTERAPIA, V73, pS21, DOI 10.1016/S0367-326X(02)00187-9
   Saavedra N, 2016, BIOMED RES INT, V2016, DOI 10.1155/2016/6505383
   Saelao P, 2020, BIOL LETTERS, V16, DOI 10.1098/rsbl.2020.0003
   Sahinler N, 2005, NAT PROD RES, V19, P183, DOI 10.1080/14786410410001704877
   Sahlan M, 2021, J KING SAUD UNIV SCI, V33, DOI 10.1016/j.jksus.2020.101234
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Salatino A, 2021, APIDOLOGIE, V52, P312, DOI 10.1007/s13592-020-00821-x
   Salmas RE, 2017, CELL BIOCHEM FUNCT, V35, P304, DOI 10.1002/cbf.3277
   Samadi N, 2017, J INTEGR MED-JIM, V15, P124, DOI 10.1016/S2095-4964(17)60315-7
   Sameni HR, 2016, J DIABETES INVEST, V7, P506, DOI 10.1111/jdi.12459
   Samiee-Rad F., 2019, FOOD NUTR RES, V7, P793, DOI [10.12691/jfnr-7-11-5, DOI 10.12691/JFNR-7-11-5]
   Sarwar N, 2010, LANCET, V375, P2215, DOI 10.1016/s0140-6736(10)60484-9
   Scholze J, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-529
   Shang H, 2020, J KING SAUD UNIV SCI, V32, P1694, DOI 10.1016/j.jksus.2020.01.003
   Shin JA, 2013, J DIABETES INVEST, V4, P334, DOI 10.1111/jdi.12075
   Sigit FS, 2020, DIABETOL METAB SYNDR, V12, DOI 10.1186/s13098-019-0503-1
   Silva DB, 2015, BRAZ J BIOL, V75, P414, DOI 10.1590/1519-6984.15313
   Silveira M., 2020, NEPHROL DIAL TRANSPL, V35, pgfaa142, DOI [10.1093/ndt/gfaa142.P1574, DOI 10.1093/NDT/GFAA142.P1574]
   Sirtori CR, 2017, ANN MED, V49, P678, DOI 10.1080/07853890.2017.1366042
   Corrêa FRS, 2017, BIOMED PHARMACOTHER, V86, P162, DOI 10.1016/j.biopha.2016.12.018
   Soleimani D, 2021, PHYTOTHER RES, V35, P1669, DOI 10.1002/ptr.6937
   Song YS, 2002, CANCER LETT, V175, P53, DOI 10.1016/S0304-3835(01)00787-X
   Spielman LJ, 2014, J NEUROIMMUNOL, V273, P8, DOI 10.1016/j.jneuroim.2014.06.004
   Spiritos Z, 2021, TRANSL GASTROENT HEP, V6, DOI 10.21037/tgh.2020.02.07
   Stone NJ, 2005, AM J CARDIOL, V96, p15E, DOI 10.1016/j.amjcard.2005.05.010
   Tahara N, 2012, CARDIOVASC THER, V30, P42, DOI 10.1111/j.1755-5922.2010.00177.x
   Tailleux A, 2012, BBA-MOL CELL BIOL L, V1821, P809, DOI 10.1016/j.bbalip.2011.10.016
   Talas ZS, 2014, CLIN EXP HYPERTENS, V36, P492, DOI 10.3109/10641963.2013.863322
   Talas ZS, 2014, CELL BIOCHEM FUNCT, V32, P150, DOI 10.1002/cbf.2986
   Teles F, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0116535
   Tsai CF, 2015, INT J MOL SCI, V16, P5572, DOI 10.3390/ijms16035572
   Tyagi A, 2020, BBA-MOL BASIS DIS, V1866, DOI 10.1016/j.bbadis.2020.165849
   Ulusoy HB, 2016, RENAL FAILURE, V38, P744, DOI 10.3109/0886022X.2016.1158070
   Unoki H, 2008, CURR PHARM DESIGN, V14, P987, DOI 10.2174/138161208784139747
   Valencia D, 2012, FOOD CHEM, V131, P645, DOI 10.1016/j.foodchem.2011.08.086
   Varbo A, 2013, J AM COLL CARDIOL, V61, P427, DOI 10.1016/j.jacc.2012.08.1026
   Walter MF, 2004, J AM COLL CARDIOL, V44, P1996, DOI 10.1016/j.jacc.2004.08.029
   Wang J, 2008, STROKE, V39, P1078, DOI 10.1161/STROKEAHA.107.499830
   Wang K, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/127672
   Wang X, 2013, DIABETES CARE, V36, P166, DOI 10.2337/dc12-0702
   Wang XL, 2014, BBA-MOL BASIS DIS, V1842, P1240, DOI 10.1016/j.bbadis.2013.10.015
   Wautier J L, 1998, Vasc Med, V3, P131, DOI 10.1177/1358836X9800300207
   Wu Z, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/906726
   Xie J, 2021, DIABETES CARE, V44, P188, DOI 10.2337/dc20-1714
   Ye MH, 2020, J FUNCT FOODS, V73, DOI 10.1016/j.jff.2020.104166
   Yemor T, 2015, J APICULT RES, V54, P468, DOI 10.1080/00218839.2016.1162447
   Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431
   Yu TZ, 2006, P NATL ACAD SCI USA, V103, P2653, DOI 10.1073/pnas.0511154103
   Yuan WW, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/5789574
   Zakerkish M, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-43838-8
   Zhang WW, 2020, J FOOD BIOCHEM, V44, DOI 10.1111/jfbc.13296
   Zhang YX, 2017, J HEALTHC ENG, V2017, DOI 10.1155/2017/3050895
   Zhao LT, 2016, INT J ENV RES PUB HE, V13, DOI 10.3390/ijerph13050498
   Zhou H, 2020, CTS-CLIN TRANSL SCI, V13, P907, DOI 10.1111/cts.12770
   Zhu AQ, 2018, J ALZHEIMERS DIS, V63, P551, DOI [10.3233/jad-170630, 10.3233/JAD-170630]
   Zulhendri F., REV J ORAL BIOSCI, V2021, DOI [10.1016/j.job.2021.01.001, DOI 10.1016/J.JOB.2021.01.001]
NR 208
TC 31
Z9 32
U1 0
U2 28
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAR
PY 2021
VL 10
IS 3
AR 348
DI 10.3390/antiox10030348
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA RD2DJ
UT WOS:000633295300001
PM 33652692
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Khan, RS
   Newsome, PN
AF Khan, Reenam S.
   Newsome, Philip N.
TI Non-alcoholic fatty liver disease and liver transplantation
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Liver
   transplantation; Metabolic syndrome
ID CORONARY-ARTERY-DISEASE; SINGLE-CENTER EXPERIENCE; LONG-TERM OUTCOMES;
   BODY-MASS INDEX; POSTOPERATIVE CARDIOVASCULAR EVENTS; DOBUTAMINE STRESS
   ECHOCARDIOGRAPHY; RANDOMIZED-CONTROLLED-TRIAL; MAJOR NONCARDIAC SURGERY;
   POPULATION-BASED COHORT; METABOLIC SYNDROME
AB Cirrhosis secondary to non-alcoholic steatohepatitis (NASH) is a common indication for liver transplant. In comparison to other cirrhotic patients, patients with NASH cirrhosis are more likely to be older and have the metabolic syndrome. Pre transplant, patients require careful evaluation of cardiovascular risk.
   As the incidence of non-alcoholic fatty liver disease (NAFLD) is rising, a greater proportion of donor grafts have steatosis greater than 30%, which is associated with poor outcomes. Grafts with steatosis greater than 60% are unsuitable for transplant.
   Overall, post-transplant survival outcomes for patients with NASH cirrhosis are similar to those with cirrhosis without NASH. However, NASH cirrhosis is associated with a higher 30 day mortality, predominantly from an increase in cardiovascular events and infections. Following liver transplant, there is a significant risk of NASH recurrence, although this seldom results in allograft loss. Furthermore, a significant number of patients who had a liver transplant for other reasons develop NASH de nouo.
   When patients with NASH cirrhosis are considered for transplant, one of the major challenges lies in identifying which patients are too high risk for surgery. This review aims to provide information to aid this decision making process, and to provide guidance on the peri-operative care strategies that can modify risk. (C) 2016 Published by Elsevier Inc.
C1 [Khan, Reenam S.] Univ Birmingham, NIHR Birmingham Liver BRU, Gastroenterol & Hepatol, Birmingham B15 2TH, W Midlands, England.
   [Khan, Reenam S.; Newsome, Philip N.] Univ Birmingham, Liver Res Ctr, Birmingham B15 2TH, W Midlands, England.
   [Newsome, Philip N.] Univ Birmingham, NIHR Birmingham Liver BRU, Hepatol, Birmingham B15 2TH, W Midlands, England.
C3 University of Birmingham; University of Birmingham; University of
   Birmingham
RP Khan, RS (corresponding author), Univ Birmingham, NIHR Birmingham Liver BRU, Gastroenterol & Hepatol, Birmingham B15 2TH, W Midlands, England.; Khan, RS (corresponding author), Univ Birmingham, Liver Res Ctr, Birmingham B15 2TH, W Midlands, England.
EM rsk409@bham.ac.uk; P.N.Newsome@bham.ac.uk
RI Newsome, Philip/D-4495-2018
OI Newsome, Philip/0000-0001-6085-3652
FU MRC [MR/L022699/1] Funding Source: UKRI; Medical Research Council
   [MR/L022699/1] Funding Source: Medline
CR Abecassis M, 2012, AM J TRANSPLANT, V12, P2608, DOI 10.1111/j.1600-6143.2012.04245.x
   Adams LA, 2005, GASTROENTEROLOGY, V129, P113, DOI 10.1053/j.gastro.2005.04.014
   Afzali A, 2012, LIVER TRANSPLANT, V18, P29, DOI 10.1002/lt.22435
   Akabame S, 2008, CIRC J, V72, P618
   Al-Nowaylati AR, 2013, LIVER TRANSPLANT, V19, P1324, DOI 10.1002/lt.23734
   Ammori JB, 2007, J SURG RES, V140, P227, DOI 10.1016/j.jss.2007.02.019
   Angulo P, 2002, NEW ENGL J MED, V346, P1221, DOI 10.1038/nrdp.2015.80
   Angulo P, 2015, GASTROENTEROLOGY, V149, P389, DOI 10.1053/j.gastro.2015.04.043
   Azarbal B, 2011, LIVER TRANSPLANT, V17, P809, DOI 10.1002/lt.22301
   Ballestri S, 2014, WORLD J GASTROENTERO, V20, P1724, DOI 10.3748/wjg.v20.i7.1724
   Bañares R, 2002, HEPATOLOGY, V36, P1367, DOI 10.1053/jhep.2002.36947
   Barritt AS, 2011, J CLIN GASTROENTEROL, V45, P372, DOI 10.1097/MCG.0b013e3181eeaff0
   Berman DS, 2004, J AM COLL CARDIOL, V44, P923, DOI 10.1016/j.jacc.2004.06.042
   Bhagat V, 2009, LIVER TRANSPLANT, V15, P1814, DOI 10.1002/lt.21927
   Bhatia LS, 2012, EUR HEART J, V33, P1190, DOI 10.1093/eurheartj/ehr453
   Bianchi G, 2008, LIVER TRANSPLANT, V14, P1648, DOI 10.1002/lt.21588
   Boin IFSF, 2007, TRANSPL P, V39, P3225, DOI 10.1016/j.transproceed.2007.08.101
   Braunfeld MY, 1996, J CLIN ANESTH, V8, P585, DOI 10.1016/S0952-8180(96)00142-0
   Burke A, 2004, AM J TRANSPLANT, V4, P686, DOI 10.1111/j.1600-6143.2004.00432.x
   Carias S, 2016, J GASTROEN HEPATOL, V31, P628, DOI 10.1111/jgh.13166
   Charlton M, 2001, LIVER TRANSPLANT, V7, P608, DOI 10.1053/jlts.2001.25453
   Charlton M, 2013, CURR OPIN ORGAN TRAN, V18, P251, DOI 10.1097/MOT.0b013e3283615d30
   Charlton MR, 2011, GASTROENTEROLOGY, V141, P1249, DOI 10.1053/j.gastro.2011.06.061
   Cho JY, 2006, TRANSPLANT INT, V19, P807, DOI 10.1111/j.1432-2277.2006.00355.x
   Contos MJ, 2001, LIVER TRANSPLANT, V7, P363, DOI 10.1053/jlts.2001.23011
   Conzen KD, 2015, HPB, V17, P251, DOI 10.1111/hpb.12340
   DALESSANDRO AM, 1991, TRANSPLANT P, V23, P1536
   Dare AJ, 2014, LIVER TRANSPLANT, V20, P281, DOI 10.1002/lt.23818
   Davidson CJ, 2002, AM J CARDIOL, V89, P359, DOI 10.1016/S0002-9149(01)02244-5
   Day CP, 2006, LIVER INT, V26, P1021, DOI 10.1111/j.1478-3231.2006.01323.x
   de Lédinghen V, 2012, LIVER INT, V32, P911, DOI 10.1111/j.1478-3231.2012.02820.x
   DeFilippis AP, 2013, ATHEROSCLEROSIS, V227, P429, DOI 10.1016/j.atherosclerosis.2013.01.022
   Dehghani SM, 2007, J GASTROENTEROL, V42, P769, DOI 10.1007/s00535-007-2092-2
   Demetris AJ, 2006, HEPATOLOGY, V44, P489, DOI 10.1002/hep.21280
   Dick AAS, 2010, LIVER TRANSPLANT, V16, P1296, DOI 10.1002/lt.22162
   Dick AAS, 2009, LIVER TRANSPLANT, V15, P968, DOI 10.1002/lt.21785
   Diedrich DA, 2008, TRANSPL P, V40, P3554, DOI 10.1016/j.transproceed.2008.08.129
   Duchini A, 2001, TRANSPLANTATION, V72, P156, DOI 10.1097/00007890-200107150-00029
   Dumortier J, 2010, AM J GASTROENTEROL, V105, P613, DOI 10.1038/ajg.2009.717
   Dunkelgrun M, 2009, ANN SURG, V249, P921, DOI 10.1097/SLA.0b013e3181a77d00
   Dunn W, 2008, AM J GASTROENTEROL, V103, P2263, DOI 10.1111/j.1572-0241.2008.02034.x
   Dureja P, 2011, TRANSPLANTATION, V91, P684, DOI 10.1097/TP.0b013e31820b6b84
   Eason JD, 2008, AM J TRANSPLANT, V8, P2243, DOI 10.1111/j.1600-6143.2008.02416.x
   Ekstedt M, 2015, HEPATOLOGY, V61, P1547, DOI 10.1002/hep.27368
   El Atrache MM, 2012, CLIN TRANSPLANT, V26, pE505, DOI 10.1111/ctr.12014
   Farkas SA, 2009, TRANSPL INT, V22, P49, DOI 10.1111/j.1432-2277.2008.00796.x
   Farrell GC, 2008, ANAT REC, V291, P684, DOI 10.1002/ar.20715
   Filsoufi Farzan, 2008, Interact Cardiovasc Thorac Surg, V7, P90, DOI 10.1510/icvts.2007.164483
   Finfer S, 2009, NEW ENGL J MED, V360, P1283, DOI 10.1056/NEJMoa0810625
   Finkenstedt A, 2013, CLIN GASTROENTEROL H, V11, P1667, DOI 10.1016/j.cgh.2013.06.025
   Fontes P, 2015, AM J TRANSPLANT, V15, P381, DOI 10.1111/ajt.12991
   Fujikawa T, 2006, TRANSPL P, V38, P3612, DOI 10.1016/j.transproceed.2006.10.188
   Fussner LA, 2014, LIVER INT, V34, P1259, DOI 10.1111/liv.12381
   Ge PS, 2014, J HEPATOL, V60, P643, DOI 10.1016/j.jhep.2013.09.016
   Gonwa TA, 2006, AM J TRANSPLANT, V6, P2651, DOI 10.1111/j.1600-6143.2006.01526.x
   Graham JA, 2014, J HEPATOL, V61, P418, DOI 10.1016/j.jhep.2014.04.019
   GRISHAM JW, 1962, CANCER RES, V22, P842
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Guckelberger O, 2006, LIVER TRANSPLANT, V12, P394, DOI 10.1002/lt.20722
   Gunay Y, 2014, LIVER TRANSPLANT, V20, P311, DOI 10.1002/lt.23794
   Haddad EM, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005161
   Hakeem AR, 2013, LIVER TRANSPLANT, V19, P551, DOI 10.1002/lt.23618
   Harinstein ME, 2008, AM J TRANSPLANT, V8, P1523, DOI 10.1111/j.1600-6143.2008.02276.x
   Heimbach JK, 2013, AM J TRANSPLANT, V13, P363, DOI 10.1111/j.1600-6143.2012.04318.x
   Hillingso JG, 2005, TRANSPL INT, V18, P1231, DOI 10.1111/j.1432-2277.2005.00206.x
   Himpens J, 2011, ARCH SURG-CHICAGO, V146, P802, DOI 10.1001/archsurg.2011.45
   Hindler K, 2006, ANESTHESIOLOGY, V105, P1260, DOI 10.1097/00000542-200612000-00027
   HLATKY MA, 1989, AM J CARDIOL, V64, P651, DOI 10.1016/0002-9149(89)90496-7
   Hoehn RS, 2015, LIVER INT, V35, P1902, DOI 10.1111/liv.12770
   Houlihan DD, 2011, LIVER TRANSPLANT, V17, P1292, DOI 10.1002/lt.22382
   Johnston SD, 2002, TRANSPLANTATION, V73, P901, DOI 10.1097/00007890-200203270-00012
   Kaplan M, 2002, HEART SURG FORUM, V5, P60
   Kaser S, 2005, GUT, V54, P117, DOI 10.1136/gut.2003.037010
   Kemmer N, 2014, TRANSPL P, V46, P230, DOI 10.1016/j.transproceed.2013.09.035
   Kemmer N, 2013, TRANSPLANTATION, V96, P860, DOI 10.1097/01.TP.0000436723.59879.01
   Kennedy C, 2012, HPB, V14, P625, DOI 10.1111/j.1477-2574.2012.00497.x
   Kim H, 2014, CLIN TRANSPLANT, V28, P521, DOI 10.1111/ctr.12343
   Kim WR, 1996, TRANSPLANTATION, V62, P1802, DOI 10.1097/00007890-199612270-00021
   Klemperer JD, 1998, ANN THORAC SURG, V65, P85, DOI 10.1016/S0003-4975(97)00931-4
   Laish I, 2011, LIVER TRANSPLANT, V17, P15, DOI 10.1002/lt.22198
   LaMattina JC, 2012, CLIN TRANSPLANT, V26, P910, DOI 10.1111/j.1399-0012.2012.01669.x
   Lebbinck H, 2006, TRANSPLANT INT, V19, P432, DOI 10.1111/j.1432-2277.2006.00298.x
   Lee TH, 1999, CIRCULATION, V100, P1043, DOI 10.1161/01.CIR.100.10.1043
   Leonard J, 2008, AM J TRANSPLANT, V8, P667, DOI 10.1111/j.1600-6143.2007.02100.x
   Lin MYC, 2013, SURG ENDOSC, V27, P81, DOI 10.1007/s00464-012-2410-5
   Lindenauer PK, 2004, JAMA-J AM MED ASSOC, V291, P2092, DOI 10.1001/jama.291.17.2092
   Liou I, 2006, J CLIN GASTROENTEROL, V40, pS11
   Maddur H, 2014, LIVER TRANSPLANT, V20, P664, DOI 10.1002/lt.23873
   Malik SM, 2009, AM J TRANSPLANT, V9, P782, DOI 10.1111/j.1600-6143.2009.02590.x
   Mangano DT, 1996, NEW ENGL J MED, V335, P1713, DOI 10.1056/NEJM199612053352301
   Marchesini G, 2003, HEPATOLOGY, V37, P917, DOI 10.1053/jhep.2003.50161
   Maurantonio M, 2011, ARCH MED RES, V42, P337, DOI 10.1016/j.arcmed.2011.08.004
   McAlister VC, 2006, AM J TRANSPLANT, V6, P1578, DOI 10.1111/j.1600-6143.2006.01360.x
   McKenney JM, 2005, AM J HEALTH-SYST PH, V62, P1033, DOI 10.1093/ajhp/62.10.1033
   Milani A, 2007, DIGEST LIVER DIS, V39, P507, DOI 10.1016/j.dld.2006.12.014
   Mofrad P, 2003, HEPATOLOGY, V37, P1286, DOI 10.1053/jhep.2003.50229
   Moon JI, 2006, TRANSPLANTATION, V82, P1625, DOI 10.1097/01.tp.0000250361.60415.96
   MORRIS JJ, 1995, J CARDIOTHOR VASC AN, V9, P322, DOI 10.1016/S1053-0770(05)80330-1
   Murray KF, 2005, HEPATOLOGY, V41, P1407, DOI 10.1002/hep.20704
   Musso G, 2011, ANN MED, V43, P617, DOI 10.3109/07853890.2010.518623
   Nair S, 2002, HEPATOLOGY, V35, P105, DOI 10.1053/jhep.2002.30318
   NBa Transplant, 2014, ANN REP LIV TRANSPL
   Newsome PN, 2012, GUT, V61, P484, DOI 10.1136/gutjnl-2011-300886
   O'Grady JG, 2002, LANCET, V360, P1119, DOI 10.1016/S0140-6736(02)11196-2
   Ojo AO, 2003, NEW ENGL J MED, V349, P931, DOI 10.1056/NEJMoa021744
   Ong JP, 2008, J HEPATOL, V49, P608, DOI 10.1016/j.jhep.2008.06.018
   Orci LA, 2013, TRANSPL INT, V26, P170, DOI 10.1111/tri.12017
   Osamah H, 1997, BRIT J CLIN PHARMACO, V44, P77, DOI 10.1046/j.1365-2125.1997.00625.x
   Paramesh AS, 2004, CLIN TRANSPLANT, V18, P94, DOI 10.1046/j.1399-0012.2003.00132.x
   Park C, 2009, TRANSPLANTATION, V87, P1031, DOI 10.1097/TP.0b013e31819cc3e6
   Perez-Protto SE, 2013, LIVER TRANSPLANT, V19, P907, DOI 10.1002/lt.23680
   Perkins James D, 2006, Liver Transpl, V12, P1012, DOI 10.1002/lt.20807
   Pletcher MJ, 2004, ARCH INTERN MED, V164, P1285, DOI 10.1001/archinte.164.12.1285
   Plotkin J S, 1996, Liver Transpl Surg, V2, P426, DOI 10.1002/lt.500020604
   Pruthi J, 2001, LIVER TRANSPLANT, V7, P811, DOI 10.1053/jlts.2001.27084
   Rafiq N, 2009, CLIN GASTROENTEROL H, V7, P234, DOI 10.1016/j.cgh.2008.11.005
   Ravikumar R, 2015, J HEPATOL, V63, P1139, DOI 10.1016/j.jhep.2015.07.005
   Reich DJ, 2005, TRANSPLANTATION, V80, P18, DOI 10.1097/01.TP.0000165118.00988.D7
   Romeo S, 2008, NAT GENET, V40, P1461, DOI 10.1038/ng.257
   Saab S, 2015, LIVER INT, V35, P164, DOI 10.1111/liv.12431
   Saadeh S, 2002, GASTROENTEROLOGY, V123, P745, DOI 10.1053/gast.2002.35354
   Samuelson AL, 2010, DIGEST DIS SCI, V55, P2089, DOI 10.1007/s10620-010-1267-5
   Sawyer RG, 1999, CLIN TRANSPLANT, V13, P126, DOI 10.1034/j.1399-0012.1999.130111.x
   Schaeffer DF, 2009, ANN HEPATOL, V8, P38, DOI 10.1016/S1665-2681(19)31809-5
   Schunkert H, 2002, INT J OBESITY, V26, pS15, DOI 10.1038/sj.ijo.0802214
   Schwimmer JB, 2008, CIRCULATION, V118, P277, DOI 10.1161/CIRCULATIONAHA.107.739920
   Segev DL, 2008, ANN SURG, V248, P863, DOI 10.1097/SLA.0b013e31818a01ef
   Segev DL, 2008, LIVER TRANSPLANT, V14, P512, DOI 10.1002/lt.21396
   Selzner M, 2000, HEPATOLOGY, V31, P35, DOI 10.1002/hep.510310108
   Selzner M, 2000, HEPATOLOGY, V32, P1280, DOI 10.1053/jhep.2000.20528
   Seo S, 2007, LIVER TRANSPLANT, V13, P844, DOI 10.1002/lt.20932
   Sersté T, 2010, HEPATOLOGY, V52, P1017, DOI 10.1002/hep.23775
   Sharma M, 2009, AM J CARDIOL, V103, P742, DOI 10.1016/j.amjcard.2008.10.037
   Sheiner PA, 2000, TRANSPLANTATION, V69, P781
   Sherman DS, 2003, AM J KIDNEY DIS, V41, P269, DOI 10.1053/ajkd.2003.50035
   Shields PL, 1999, TRANSPLANTATION, V68, P530, DOI 10.1097/00007890-199908270-00015
   Singal AK, 2013, TRANSPLANTATION, V95, P755, DOI 10.1097/TP.0b013e31827afb3a
   Singal AK, 2016, TRANSPLANTATION, V100, P607, DOI 10.1097/TP.0000000000000945
   Singhal A, 2015, TRANSPL INT, V28, P148, DOI 10.1111/tri.12483
   Smith TB, 2009, ANAESTHESIA, V64, P883, DOI 10.1111/j.1365-2044.2009.05983.x
   Snipelisky D, 2014, CLIN CARDIOL, V37, P468, DOI 10.1002/clc.22283
   Snipelisky DF, 2015, TEX HEART I J, V42, P438, DOI 10.14503/THIJ-14-4738
   Sprinzl MF, 2013, TRANSPL INT, V26, P67, DOI 10.1111/j.1432-2277.2012.01576.x
   STEGALL MD, 1995, TRANSPLANTATION, V60, P1057
   Stickel F, 2008, NUTR REV, V66, P47, DOI 10.1111/j.1753-4887.2007.00005.x
   Tanaka T, 2013, TRANSPL P, V45, P2288, DOI 10.1016/j.transproceed.2012.11.009
   Tanaka T, 2014, HEPATOL RES, V44, pE3, DOI 10.1111/hepr.12200
   Targher G, 2011, J HEPATOL, V54, P1020, DOI 10.1016/j.jhep.2010.11.007
   Targher G, 2010, NEW ENGL J MED, V363, P1341, DOI 10.1056/NEJMra0912063
   Testino G, 2013, MINERVA MED, V104, P225
   Tevar AD, 2010, J AM COLL SURGEONS, V210, P515, DOI 10.1016/j.jamcollsurg.2010.01.020
   Torregrosa M, 2005, J HEPATOL, V42, P68, DOI 10.1016/j.jhep.2004.09.008
   Tripathi D, 2010, EUR J GASTROEN HEPAT, V22, P905, DOI 10.1097/MEG.0b013e3283367a99
   Tueche SG, 2003, TRANSPLANT P, V35, P1466, DOI 10.1016/S0041-1345(03)00528-1
   Vallin M, 2014, LIVER TRANSPLANT, V20, P1064, DOI 10.1002/lt.23936
   VanWagner LB, 2015, LIVER INT
   VanWagner LB, 2012, HEPATOLOGY, V56, P1741, DOI 10.1002/hep.25855
   Veldt BJ, 2012, AM J TRANSPLANT, V12, P737, DOI 10.1111/j.1600-6143.2011.03843.x
   Vernon G, 2011, ALIMENT PHARM THER, V34, P274, DOI 10.1111/j.1365-2036.2011.04724.x
   Verran D, 2003, LIVER TRANSPLANT, V9, P500, DOI 10.1053/jlts.2003.50099
   Villanova N, 2005, HEPATOLOGY, V42, P473, DOI 10.1002/hep.20781
   Wang XF, 2014, CLIN GASTROENTEROL H, V12, P394, DOI 10.1016/j.cgh.2013.09.023
   Watt KD, 2013, AM J TRANSPLANT, V13, P2450, DOI 10.1111/ajt.12355
   Watt KDS, 2010, J HEPATOL, V53, P199, DOI 10.1016/j.jhep.2010.01.040
   Weber ML, 2012, LIVER TRANSPLANT, V18, P1290, DOI 10.1002/lt.23522
   Weber M, 2013, EUR HEART J, V34, P853, DOI 10.1093/eurheartj/ehs445
   Werneck M, 2011, TRANSPL P, V43, P165, DOI 10.1016/j.transproceed.2010.12.004
   Williams CD, 2011, GASTROENTEROLOGY, V140, P124, DOI 10.1053/j.gastro.2010.09.038
   Williams R, 2014, LANCET, V384, P1953, DOI 10.1016/S0140-6736(14)61838-9
   Wiper A, 2008, J POSTGRAD MED, V54, P152, DOI 10.4103/0022-3859.40787
   Wong F, 2001, GUT, V49, P268, DOI 10.1136/gut.49.2.268
   Wong RJ, 2015, GASTROENTEROLOGY, V148, P547, DOI 10.1053/j.gastro.2014.11.039
   Wong TC, 2015, LIVER TRANSPL
   Wray C, 2013, AM J TRANSPLANT, V13, P184, DOI 10.1111/j.1600-6143.2012.04293.x
   Yalamanchili K, 2010, LIVER TRANSPLANT, V16, P431, DOI 10.1002/lt.22004
   Yong CM, 2010, LIVER TRANSPLANT, V16, P1242, DOI 10.1002/lt.22152
   Younossi ZM., 2015, Hepatology
NR 177
TC 39
Z9 41
U1 0
U2 8
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD AUG
PY 2016
VL 65
IS 8
BP 1208
EP 1223
DI 10.1016/j.metabol.2016.02.013
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DR4RH
UT WOS:000379889400018
PM 26997540
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Kwon, YE
   Ha, JE
   Paik, DI
   Jin, BH
   Bae, KH
AF Kwon, Young-Eun
   Ha, Jung-Eun
   Paik, Dai-Il
   Jin, Bo-Hyoung
   Bae, Kwang-Hak
TI The relationship between periodontitis and metabolic syndrome among a
   Korean nationally representative sample of adults
SO JOURNAL OF CLINICAL PERIODONTOLOGY
LA English
DT Article
DE Korean National Health and Nutrition Examination (KNHANES); metabolic
   syndrome; periodontal disease; relationship
ID AMERICAN-DIABETES-ASSOCIATION; OXIDATIVE STRESS; UNITED-STATES;
   INSULIN-RESISTANCE; CRITICAL-APPRAISAL; JOINT STATEMENT; YOUNG-ADULTS;
   DISEASE; DEFINITION; PREVALENCE
AB Aims: The aim of this study was to examine whether metabolic syndrome (MS) is associated with periodontitis in a representative sample of Korean adults, who were involved in the Fourth Korea National Health and Nutrition Examination Survey (KNHANES).
   Materials and Methods: A total of 7178 subjects over the age of 19 years who participated in KNHANES were examined. MS was defined as the definition proposed by the National Cholesterol Education Program Adult Treatment Panel III and the abdominal obesity cut-off line based on Korean Society for the Study of Obesity. The periodontal status was assessed by the Community Periodontal Index. Multivariate logistic regression analysis was carried out adjusting for the sociodemographics, oral health behaviours and status, and health behaviour. All analyses considered a complex sampling design, and multivariate analysis was also performed in the subgroups (age, gender, current smoking status).
   Results: Multivariate logistic regression analysis revealed significant associations between MS and periodontitis. After adjusting for all covariates, the adjusted odds ratio (OR) of periodontitis (community periodontal index >= 3) was 1.55 (1.32-1.83) for MS. In subgroup analysis, periodontitis is associated with MS in subjects over age 40 and the adjusted ORs were higher in females and in the smoker group than in males and in non-smokers.
   Conclusions: MS is associated with periodontitis.
C1 [Kwon, Young-Eun; Ha, Jung-Eun; Paik, Dai-Il; Jin, Bo-Hyoung; Bae, Kwang-Hak] Seoul Natl Univ, Sch Dent, Dept Prevent & Publ Hlth Dent, Seoul 110749, South Korea.
   [Kwon, Young-Eun] Korea Canc Ctr Hosp, Dept Dent, Seoul, South Korea.
   [Ha, Jung-Eun; Paik, Dai-Il; Jin, Bo-Hyoung; Bae, Kwang-Hak] Seoul Natl Univ, Dent Res Inst, Sch Dent, Seoul, South Korea.
C3 Seoul National University (SNU); National Cancer Center - Korea (NCC);
   Seoul National University (SNU)
RP Bae, KH (corresponding author), Seoul Natl Univ, Sch Dent, Dept Prevent & Publ Hlth Dent, 28 Yeongeuon Dong, Seoul 110749, South Korea.
EM baekh@snu.ac.kr
RI jin, bo-hyoung/AAU-8576-2021
CR Acharya A, 2010, METAB SYNDR RELAT D, V8, P335, DOI 10.1089/met.2010.0002
   Albandar JM, 1999, J PERIODONTOL, V70, P13, DOI 10.1902/jop.1999.70.1.13
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   [Anonymous], 1997, ORAL HLTH SURVEYS BA, V4th, P6
   Balkau B, 2002, DIABETES METAB, V28, P364
   Benguigui C, 2010, J CLIN PERIODONTOL, V37, P601, DOI 10.1111/j.1600-051X.2010.01571.x
   Bullon P, 2009, J DENT RES, V88, P503, DOI 10.1177/0022034509337479
   Bustos P, 2007, NUTR METAB CARDIOVAS, V17, P581, DOI 10.1016/j.numecd.2006.06.001
   Cameron AJ, 2004, ENDOCRIN METAB CLIN, V33, P351, DOI 10.1016/j.ecl.2004.03.005
   Cheta DM, 2006, DIABETES CARE, V29, P176, DOI 10.2337/diacare.29.1.176-a
   Citrome L, 2006, DIABETES CARE, V29, P176, DOI 10.2337/diacare.29.01.06.dc05-1673
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   D'Aiuto F, 2010, J DENT RES, V89, P1241, DOI 10.1177/0022034510375830
   D'Aiuto F, 2008, J CLIN ENDOCR METAB, V93, P3989, DOI 10.1210/jc.2007-2522
   Eckel RH, 2010, LANCET, V375, P181, DOI 10.1016/S0140-6736(09)61794-3
   Genco RJ, 1996, J PERIODONTOL, V67, P1041, DOI 10.1902/jop.1996.67.10s.1041
   Giugliano D, 2006, DIABETES CARE, V29, P175, DOI 10.2337/diacare.29.01.06.dc05-1646
   Grundy SM, 2006, DIABETES CARE, V29, P1689, DOI 10.2337/dc05-2307
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Han DH, 2010, J CLIN PERIODONTOL, V37, P609, DOI 10.1111/j.1600-051X.2010.01580.x
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   *KCDC, 2008, STAND OR HLTH SURV K
   Khader Y, 2008, J PERIODONTOL, V79, P2048, DOI [10.1902/jop.2008.080022, 10.1902/jop.2008.080022 ]
   Kingman A, 2002, PERIODONTOL 2000, V29, P11, DOI 10.1034/j.1600-0757.2002.290102.x
   Korea National Statistical Office, 2005, POP PROJ KOR
   Kushiyama M, 2009, J PERIODONTOL, V80, P1610, DOI 10.1902/jop.2009.090218
   Li P, 2009, J PERIODONTOL, V80, P541, DOI 10.1902/jop.2009.080387
   *MIN HLTH WELF KOR, 2008, KOR NAT HLTH EX SURV
   Morita T, 2010, J PERIODONTOL, V81, P512, DOI 10.1902/jop.2010.090594
   Ohnishi T, 2009, J PERIODONTAL RES, V44, P43, DOI 10.1111/j.1600-0765.2007.01060.x
   Park J, 2008, ASIA PAC J CLIN NUTR, V17, P471
   Park J, 2010, J KOREAN MED SCI, V25, P75, DOI 10.3346/jkms.2010.25.1.75
   Psaty BM, 2006, DIABETES CARE, V29, P177, DOI 10.2337/diacare.29.1.177
   Rakugi H, 2005, CURR HYPERTENS REP, V7, P103, DOI 10.1007/s11906-005-0082-4
   Saito T, 2007, PERIODONTOL 2000, V43, P254, DOI 10.1111/j.1600-0757.2006.00186.x
   Sarti C, 2006, J DIABETES COMPLICAT, V20, P121, DOI 10.1016/j.jdiacomp.2005.06.014
   Shimazaki Y, 2007, J DENT RES, V86, P271, DOI 10.1177/154405910708600314
   Taylor G W, 2001, Ann Periodontol, V6, P99, DOI 10.1902/annals.2001.6.1.99
   Timonen P, 2010, J DENT RES, V89, P1068, DOI 10.1177/0022034510376542
   WHO WFP UNICEF, 2007, PREV CONTR MICR DEF, P2
   WILLIAMS RC, 1990, NEW ENGL J MED, V322, P373, DOI 10.1056/NEJM199002083220606
NR 43
TC 76
Z9 83
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-6979
EI 1600-051X
J9 J CLIN PERIODONTOL
JI J. Clin. Periodontol.
PD SEP
PY 2011
VL 38
IS 9
BP 781
EP 786
DI 10.1111/j.1600-051X.2011.01756.x
PG 6
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA 806HA
UT WOS:000293795700001
PM 21722155
OA Bronze
DA 2025-06-11
ER

PT J
AU Li, XY
   Huang, HY
   Xu, HJ
   Shi, Y
   Qian, YJ
   Zou, JY
   Yi, HL
   Guan, J
   Yin, SK
AF Li, Xinyi
   Huang, Hengye
   Xu, Huajun
   Shi, Yue
   Qian, Yingjun
   Zou, Jianyin
   Yi, Hongliang
   Guan, Jian
   Yin, Shankai
TI Excessive daytime sleepiness, metabolic syndrome, and obstructive sleep
   apnea: two independent large cross-sectional studies and one
   interventional study
SO RESPIRATORY RESEARCH
LA English
DT Article
DE Obstructive sleep apnea; Excessive daytime sleepiness; Metabolic
   syndrome; Upper-airway surgery
ID INSULIN-RESISTANCE; OBESITY; ASSOCIATION; DEPRESSION; MODERATE; SCALE
AB Background: Obstructive sleep apnea (OSA) and excessive daytime sleepiness (EDS) were considered to contribute to MetS. This study was performed to assess the association between MetS and EDS in two independent large-scale populations, and in subjects who underwent upper-airway surgery.
   Methods: A total of 6312 patients without self-reported depression and 3578 suspected OSA patients were consecutively recruited, during health screening examinations and from our sleep center, respectively. A total of 57 subjects with OSA who underwent upper-airway surgery were also included. Demographic, anthropometric, biochemical, and polysomnographic data were obtained.
   Results: In the health screening examination group, 233 (9.23%) women and 350 (10.93%) men had complaints of EDS. A total of 229 (7.04%) women and 1182 (36.88%) men met the criteria for MetS. In the OSA group, 147 (21.18%) women and 1058 (36.69%) men reported EDS. In addition, 93 (13.4%) women and 1368 (47.43%) men reported MetS. In the health screening examination group, EDS did not contribute significantly to MetS (OR = 1.125, 95% CI: 0.907-1.395; p = 0.283). In the OSA group, EDS significantly contributed to MetS (OR = 1.249, 95% CI: 1.063-1.468; p = 0.007); however, the results were not significant after adjusting for sleep variables (OR = 1.071, 95% CI: 0.905-1.268; p = 0.423). Upper-airway surgery did not affect cardio-metabolic variables in OSA patients with or without EDS.
   Conclusions: EDS was not associated with MetS in two independent large-scale cohorts. In addition, upper-airway surgery did not affect components of MetS in OSA patients with and without EDS.
C1 [Li, Xinyi; Xu, Huajun; Qian, Yingjun; Zou, Jianyin; Yi, Hongliang; Guan, Jian; Yin, Shankai] Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Dept Otolaryngol Head & Neck Surg, Yishan Rd 600, Shanghai 200233, Peoples R China.
   [Li, Xinyi; Xu, Huajun; Qian, Yingjun; Zou, Jianyin; Yi, Hongliang; Guan, Jian; Yin, Shankai] Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Ctr Sleep Med, Yishan Rd 600, Shanghai 200233, Peoples R China.
   [Li, Xinyi; Xu, Huajun; Qian, Yingjun; Zou, Jianyin; Yi, Hongliang; Guan, Jian; Yin, Shankai] Shanghai Key Lab Sleep Disordered Breathing, Yishan Rd 600, Shanghai 200233, Peoples R China.
   [Li, Xinyi; Xu, Huajun; Qian, Yingjun; Zou, Jianyin; Yi, Hongliang; Guan, Jian; Yin, Shankai] Shanghai Jiao Tong Univ, Otolaryngol Inst, Yishan Rd 600, Shanghai 200233, Peoples R China.
   [Huang, Hengye; Shi, Yue] Shanghai Jiao Tong Univ, Sch Publ Hlth, Sch Med, 225South Chongqing Rd, Shanghai 200020, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai
   Jiao Tong University; Shanghai Jiao Tong University
RP Xu, HJ; Yi, HL (corresponding author), Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Dept Otolaryngol Head & Neck Surg, Yishan Rd 600, Shanghai 200233, Peoples R China.; Xu, HJ; Yi, HL (corresponding author), Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Ctr Sleep Med, Yishan Rd 600, Shanghai 200233, Peoples R China.
EM sunnydayxu2010@163.com; yihongl@126.com
RI li, xinyi/GWZ-8941-2022; xu, huajun/KQT-9241-2024
FU National Key R&D Program of China [2017YFC0112500]; Joint Project of New
   Frontier Technology of Shanghai Shen-kang Hospital Development Center
   [SHDC 12014240, 16CR3103B]; Innovation Program of Shanghai Municipal
   Education Commission [2017-01-07-00-02-E00047]; National Natural Science
   Foundation of China [81770987, 81700896, 81701306, 81770988]; Shanghai
   Sailing Program [17YF1414300]; multi-center clinical research project
   from school of medicine, Shanghai Jiao Tong University [DLY201502];
   Shanghai Shen-Kang Hospital Management Center [SHDC12015101]
FX This study was supported by grants-in-aid from National Key R&D Program
   of China (2017YFC0112500); The Joint Project of New Frontier Technology
   of Shanghai Shen-kang Hospital Development Center (SHDC 12014240,
   16CR3103B); Innovation Program of Shanghai Municipal Education
   Commission (2017-01-07-00-02-E00047); National Natural Science
   Foundation of China (81770987, 81700896, 81701306, 81770988); Shanghai
   Sailing Program (17YF1414300); multi-center clinical research project
   from school of medicine, Shanghai Jiao Tong University (DLY201502) and
   Shanghai Shen-Kang Hospital Management Center Project (SHDC12015101).
CR Agrawal S, 2012, SLEEP BREATH, V16, P621, DOI 10.1007/s11325-011-0548-3
   Barceló A, 2008, THORAX, V63, P946, DOI 10.1136/thx.2007.093740
   Bisogni V, 2017, INT J CARDIOL, V236, P458, DOI 10.1016/j.ijcard.2017.01.149
   Bixler EO, 2005, J CLIN ENDOCR METAB, V90, P4510, DOI 10.1210/jc.2005-0035
   Bonsignore MR, 2012, EUR RESPIR J, V39, P1136, DOI 10.1183/09031936.00151110
   Dixon JB, 2007, OBESITY, V15, P2504, DOI 10.1038/oby.2007.297
   Fu YQ, 2017, ONCOTARGET, V8, P79693, DOI 10.18632/oncotarget.19113
   Gonçalves MA, 2004, CHEST, V125, P2091, DOI 10.1378/chest.125.6.2091
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hayley AC, 2015, METABOLISM, V64, P244, DOI 10.1016/j.metabol.2014.09.011
   Herman J, 2014, INJURY, V45, P586, DOI 10.1016/j.injury.2013.06.007
   Huang JF, 2016, CLIN RESPIR J, V10, P714, DOI 10.1111/crj.12276
   Iber CA-IS, 2007, WESTCHEST IL AM ACAD, V2007
   Johns M, 1997, SLEEP, V20, P844, DOI 10.1093/sleep/20.10.844
   JOHNS MW, 1991, SLEEP, V14, P540, DOI 10.1093/sleep/14.6.540
   Johns MW, 2000, J SLEEP RES, V9, P5, DOI 10.1046/j.1365-2869.2000.00177.x
   Jordan AS, 2014, LANCET, V383, P736, DOI 10.1016/S0140-6736(13)60734-5
   Kapur VK, 2005, SLEEP, V28, P472, DOI 10.1093/sleep/28.4.472
   Kritikou I, 2014, EUR RESPIR J, V43, P145, DOI 10.1183/09031936.00126712
   LaGrotte C, 2016, INT J OBESITY, V40, P1397, DOI 10.1038/ijo.2016.87
   Lai CC, 2018, ANN OTO RHINOL LARYN, V127, P912, DOI 10.1177/0003489418800089
   Li L, 2014, MED SCI MONITOR, V20, P2651, DOI 10.12659/MSM.892230
   Lindberg E, 2001, AM J RESP CRIT CARE, V164, P2031, DOI 10.1164/ajrccm.164.11.2102028
   Maugeri A, 2018, NUTRIENTS, V10, DOI 10.3390/nu10091219
   McAuley KA, 2001, DIABETES CARE, V24, P460, DOI 10.2337/diacare.24.3.460
   Ng TP, 2005, SLEEP MED, V6, P523, DOI 10.1016/j.sleep.2005.01.007
   Ng WL, 2017, OBES REV, V18, P460, DOI 10.1111/obr.12498
   Ng WL, 2017, SLEEP MED, V36, P109, DOI 10.1016/j.sleep.2017.05.004
   Ogilvie RP, 2018, SLEEP MED, V44, P32, DOI 10.1016/j.sleep.2018.01.004
   Ohashi M, 2018, CIRC J, V82, P2175, DOI 10.1253/circj.CJ-17-1395
   Ren R, 2016, HYPERTENSION, V68, P1264, DOI 10.1161/HYPERTENSIONAHA.115.06941
   Siarnik P, 2018, J CLIN SLEEP MED, V14, P95, DOI 10.5664/jcsm.6890
   Vgontzas AN, 1998, ARCH INTERN MED, V158, P1333, DOI 10.1001/archinte.158.12.1333
   Xu HJ, 2016, SLEEP BREATH, V20, P627, DOI 10.1007/s11325-015-1262-3
NR 34
TC 13
Z9 14
U1 0
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1465-993X
J9 RESP RES
JI Respir. Res.
PD DEC 4
PY 2019
VL 20
IS 1
AR 276
DI 10.1186/s12931-019-1248-y
PG 8
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA KH8YJ
UT WOS:000510936000003
PM 31801522
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zheng, NN
   Wei, D
   Dai, B
   Zheng, LY
   Zhao, MY
   Xin, N
   Chi, ZH
   Zhao, YT
   Ma, TX
   Jahane, R
   Sun, LN
AF Zheng, Ningning
   Wei, Dan
   Dai, Bo
   Zheng, Lanyan
   Zhao, Mingyi
   Xin, Na
   Chi, Zhihong
   Zhao, Yiting
   Ma, Tingxian
   Jahane, Rabita
   Sun, Luning
TI Mitochondrial Genome Encoded Proteins Expression Disorder, the Possible
   Mechanism of the Heart Disease in Metabolic Syndrome
SO CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Metabolic Syndrome; Heart Disease; Mitochondrion Encoded Protein;
   Mitochondrial Ribosomal Proteins
ID ELECTRON-TRANSFER FLAVOPROTEIN; OXIDATIVE STRESS; ATP SYNTHESIS; DNA
   MUTATION; TRANSPORT; ADULTS; CHAIN; NARP; PROLIFERATION; DEGRADATION
AB Background/Aims: The direct consequence of metabolic syndrome (MS) is the increased morbidity and mortality caused by the heart disease. We tried to explain why the heart is more severely damaged during MS from the point of mitochondria, the center of cellular metabolism. Methods: 1. The classic diet induced MS rat model was used to observe the morphological changes of mitochondria by transmission electron microscope (TEM); 2. The expression of mitochondrial DNA (mt-DNA) encoded proteins was observed by immunohistochemistry and Western blot; 3. The expression of mitochondrial ribosomal proteins (MRPs) was observed by real-time PCR. Results: 1. The mitochondrial volume increased but the number was normal in myocardial cells of the MS rats. But in the hepatocytes and skeletal muscle cells, the mitochondrial number decreased; 2. The mt-DNA encoded protein cytochrome b increased significantly in heart but decreased in liver and the ATPase6 increased in liver but decreased in heart of the MS rats; 3. The mRNA levels of MRPS23, MRPL27, MRPL45 and MRPL48 elevated in heart but down-regulated in liver of the MS rats. Conclusion: The morphologic and functional alterations of mitochondrion in MS were tissue specific. Heart displays a distinctive pattern of mitochondrial metabolic status compared with other tissues. (C) 2017 The Author(s) Published by S. Karger AG, Basel
C1 [Zheng, Ningning; Xin, Na; Chi, Zhihong; Ma, Tingxian; Sun, Luning] China Med Univ, Coll Basic Med Sci, Dept Pathophysiol, Shenyang, Liaoning, Peoples R China.
   [Wei, Dan; Dai, Bo] China Med Univ, Grad Sch, Dept Pathophysiol, Shenyang, Liaoning, Peoples R China.
   [Zheng, Lanyan] China Med Univ, Coll Basic Med Sci, Dept Pathogen Biol, Shenyang, Liaoning, Peoples R China.
   [Zhao, Mingyi] Shenyang Pharmaceut Univ, Dept Clin Pharm, Shenyang, Liaoning, Peoples R China.
   [Zhao, Yiting] Chinese Acad Med Sci, Canc Hosp, PET CT Ctr, Beijing, Peoples R China.
   [Jahane, Rabita] China Med Univ, Int Educ Sch, Shenyang, Liaoning, Peoples R China.
C3 China Medical University; China Medical University; China Medical
   University; Shenyang Pharmaceutical University; Chinese Academy of
   Medical Sciences - Peking Union Medical College; Cancer Institute &
   Hospital - CAMS; China Medical University
RP Sun, LN (corresponding author), China Med Univ, Coll Basic Med Sci, Dept Pathophysiol, Shenyang North New Area, 77 Puhe Rd, Shenyang, Liaoning, Peoples R China.
EM lnsun@cmu.edu.cn
RI Zheng, Ningning/KHU-0389-2024; Zhang, Tingting/GXF-5248-2022
FU National Natural Science Foundation of China [30900567]
FX This work was supported by a grant from National Natural Science
   Foundation of China (30900567).
CR Acin-Pérez R, 2008, MOL CELL, V32, P529, DOI 10.1016/j.molcel.2008.10.021
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Aral C, 2011, HORM-INT J ENDOCRINO, V10, P298, DOI 10.14310/horm.2002.1321
   BECKMANN JD, 1985, BIOCHEMISTRY-US, V24, P3913, DOI 10.1021/bi00336a016
   Chen Q, 2003, J BIOL CHEM, V278, P36027, DOI 10.1074/jbc.M304854200
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cocco T, 1999, FREE RADICAL BIO MED, V27, P51, DOI 10.1016/S0891-5849(99)00034-9
   Detmer SA, 2007, NAT REV MOL CELL BIO, V8, P870, DOI 10.1038/nrm2275
   Ford ES, 2010, J DIABETES, V2, P180, DOI 10.1111/j.1753-0407.2010.00078.x
   Fung S, 2013, MOL BIOL CELL, V24, P184, DOI 10.1091/mbc.E12-09-0651
   Galloway CA, 2013, ANTIOXID REDOX SIGN, V19, P415, DOI 10.1089/ars.2012.4779
   Gatza ML, 2014, NAT GENET, V46, P1051, DOI 10.1038/ng.3073
   Harada T, 2010, APOPTOSIS, V15, P1247, DOI 10.1007/s10495-010-0519-3
   Heinonen S, 2015, DIABETES, V64, P3135, DOI 10.2337/db14-1937
   Ilkun O, 2013, CURR PHARM DESIGN, V19, P4806, DOI 10.2174/1381612811319270003
   Juo SHH, 2010, MITOCHONDRION, V10, P294, DOI 10.1016/j.mito.2010.01.001
   Kim JJP, 2002, CURR OPIN STRUC BIOL, V12, P721, DOI 10.1016/S0959-440X(02)00390-1
   Kwasniak M, 2013, PLANT CELL, V25, P1855, DOI 10.1105/tpc.113.111294
   Lemasters JJ, 2002, ANTIOXID REDOX SIGN, V4, P769, DOI 10.1089/152308602760598918
   Lim SK, 2007, BIOCHEM J, V403, P119, DOI 10.1042/BJ20061272
   Mackenzie J, 2006, J BIOL CHEM, V281, P31012, DOI 10.1074/jbc.M603405200
   Mandavia CH, 2012, METABOLISM, V61, P1205, DOI 10.1016/j.metabol.2012.02.013
   Mattiazzi M, 2004, HUM MOL GENET, V13, P869, DOI 10.1093/hmg/ddh103
   Nichols TW, 2012, MED HYPOTHESES, V79, P287, DOI 10.1016/j.mehy.2012.05.006
   Palmieri VO, 2011, NUTRITION, V27, P773, DOI 10.1016/j.nut.2010.08.016
   Phung TL, 2015, CANCER RES, V75, P40, DOI 10.1158/0008-5472.CAN-13-2961
   Pich S, 2005, HUM MOL GENET, V14, P1405, DOI 10.1093/hmg/ddi149
   RAMSAY RR, 1987, BIOCHEM J, V241, P883, DOI 10.1042/bj2410883
   Raza H, 2015, CELL PHYSIOL BIOCHEM, V35, P1241, DOI 10.1159/000373947
   Roul D, 2015, ANTIOXID REDOX SIGN, V22, P1502, DOI 10.1089/ars.2015.6311
   RUZICKA FJ, 1977, J BIOL CHEM, V252, P8440
   Schönfeld P, 2007, BBA-BIOENERGETICS, V1767, P1032, DOI 10.1016/j.bbabio.2007.04.005
   Schönfeld P, 2006, J BIOL CHEM, V281, P7136, DOI 10.1074/jbc.M513198200
   Sgarbi G, 2006, BIOCHEM J, V395, P493, DOI 10.1042/BJ20051748
   St-Pierre J, 2002, J BIOL CHEM, V277, P44784, DOI 10.1074/jbc.M207217200
   Suh I, 2010, ARCH SURG-CHICAGO, V145, P226, DOI 10.1001/archsurg.2009.292
   Sumner AD, 2012, J CLIN HYPERTENS, V14, P502, DOI 10.1111/j.1751-7176.2012.00647.x
   TATUCH Y, 1993, BIOCHEM BIOPH RES CO, V192, P124, DOI 10.1006/bbrc.1993.1390
   Terman Alexei, 2006, Molecular Aspects of Medicine, V27, P471, DOI 10.1016/j.mam.2006.08.006
   Thyfault JP, 2011, J APPL PHYSIOL, V111, P1218, DOI 10.1152/japplphysiol.00478.2011
   Walder Ken, 2002, Endocr Regul, V36, P1
   Yang WY, 2010, NEW ENGL J MED, V362, P1090, DOI 10.1056/NEJMoa0908292
   Ye W, 2013, MOL MED REP, V8, P1060, DOI 10.3892/mmr.2013.1616
   Zheng NN, 2015, CELL PHYSIOL BIOCHEM, V36, P1903, DOI 10.1159/000430159
NR 44
TC 8
Z9 10
U1 0
U2 7
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1015-8987
EI 1421-9778
J9 CELL PHYSIOL BIOCHEM
JI Cell. Physiol. Biochem.
PY 2017
VL 43
IS 3
BP 959
EP 968
DI 10.1159/000481649
PG 10
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA FN7TI
UT WOS:000416221300008
PM 28957804
OA gold
DA 2025-06-11
ER

PT J
AU Hwang, AC
   Lin, YC
   Liu, PT
   Kao, YM
   Chen, JD
AF Hwang, An-Chun
   Lin, Yu-Cheng
   Liu, Peng-Tzu
   Kao, Yu-Man
   Chen, Jong-Dar
TI Synergistic effect of gamma glutamyltransferase and obesity on metabolic
   syndrome, independent of hepatic steatosis
SO ANNALS OF EPIDEMIOLOGY
LA English
DT Article
DE Metabolic syndrome; Insulin resistance; Cardiovascular diseases;
   Gammaglutamyltransferase; Obesity; Body mass index
ID GLUTAMYL-TRANSFERASE; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; RISK;
   TRANSPEPTIDASE; MORTALITY; HEART; ATHEROSCLEROSIS; ASSOCIATION; ADULTS
AB Purpose: Both obesity and gamma glutamyltransferase (GGT) are individually considered to be closely associated with metabolic syndrome (MetS). Whether the 2 factors synergistically associate with MetS is not yet confirmed. The purpose of this study was to investigate whether obesity and GGT are interactively associated with MetS.
   Methods: A cross-sectional study of 7390 adults (age 32-62 years old) was conducted from 2009 to 2010.
   Results: Our results showed that greater serum GGT quartiles were positively associated with all MetS components and fatty liver (P < .001). The odds ratio of MetS increased significantly along with quartiles of GGT and obesity. In comparison with subjects with normal body mass index and first quartile GGT, the odds ratio of MetS in obese groups with 1st, 2nd, 3rd, and 4th quartile GGT were 6.8, 14.5, 20.3, and 45.2, respectively, and it remained tenable after adjustment for fatty liver. The synergy index of GGT and obesity on MetS is 2.2 (95% confidence interval, 1.9-2.6).
   Conclusions: Serum GGT level in combination with obesity can be a simple but useful tool for risk stratification of developing MetS. Obese individuals with high normal GGT levels require close monitoring for high risk of MetS. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Hwang, An-Chun; Liu, Peng-Tzu; Kao, Yu-Man; Chen, Jong-Dar] Shin Kong Wu Ho Su Mem Hosp, Dept Family Med, Taipei 111, Taiwan.
   [Lin, Yu-Cheng] En Chu Kong Hosp, Dept Occupat Med, Taipei, Taiwan.
   [Chen, Jong-Dar] Fu Jen Catholic Univ, Sch Med, Taipei, Taiwan.
C3 Shin Kong Wu Ho Su Memorial Hospital; Fu Jen Catholic University
RP Chen, JD (corresponding author), Shin Kong Wu Ho Su Mem Hosp, Dept Family Med, 95 Wen Chang Rd, Taipei 111, Taiwan.
EM m006671@ms.skh.org.tw
RI Liu, Chia-Ju/AAX-8643-2021
CR Fraser A, 2007, ARTERIOSCL THROM VAS, V27, P2729, DOI 10.1161/ATVBAHA.107.152298
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Hamaguchi M, 2005, ANN INTERN MED, V143, P722, DOI 10.7326/0003-4819-143-10-200511150-00009
   HANIGAN MH, 1993, BIOCHEMISTRY-US, V32, P6302, DOI 10.1021/bi00075a026
   Hanley AJG, 2004, DIABETES, V53, P2623, DOI 10.2337/diabetes.53.10.2623
   Hochwald SN, 1996, J NATL CANCER I, V88, P193, DOI 10.1093/jnci/88.3-4.193
   Karp DR, 2001, J BIOL CHEM, V276, P3798, DOI 10.1074/jbc.M008484200
   Lee DH, 2004, FREE RADICAL RES, V38, P535, DOI 10.1080/10715760410001694026
   Lee DH, 2003, CLIN CHEM, V49, P1358, DOI 10.1373/49.8.1358
   Lee DS, 2007, ARTERIOSCL THROM VAS, V27, P127, DOI 10.1161/01.ATV.0000251993.20372.40
   Lee DH, 2009, EUR J CARDIOV PREV R, V16, P16, DOI 10.1097/HJR.0b013e32830aba5c
   Lee MY, 2008, DIABETIC MED, V25, P469, DOI 10.1111/j.1464-5491.2008.02415.x
   Li M, 2009, OBESITY, V17, P809, DOI 10.1038/oby.2008.617
   Lim JS, 2007, CLIN CHEM, V53, P1092, DOI 10.1373/clinchem.2006.079814
   Mason Jennifer E, 2010, Prev Cardiol, V13, P36, DOI 10.1111/j.1751-7141.2009.00054.x
   Onat A, 2012, OBESITY, V20, P842, DOI 10.1038/oby.2011.136
   Paolicchi A, 1999, J INVEST MED, V47, P151
   Paolicchi A, 2006, ATHEROSCLEROSIS, V186, P80, DOI 10.1016/j.atherosclerosis.2005.07.012
   Paolicchi A, 2004, CIRCULATION, V109, P1440, DOI 10.1161/01.CIR.0000120558.41356.E6
   Pompella A, 2004, CLIN CHEM LAB MED, V42, P1085, DOI 10.1515/CCLM.2004.224
   Ruttmann E, 2005, CIRCULATION, V112, P2130, DOI 10.1161/CIRCULATIONAHA.105.552547
   Ryu S, 2010, METABOLISM, V59, P683, DOI 10.1016/j.metabol.2009.08.024
   Shimizu Y, 2010, STROKE, V41, P385, DOI 10.1161/STROKEAHA.109.569061
   WANNAMETHEE G, 1995, AM J EPIDEMIOL, V142, P699, DOI 10.1093/oxfordjournals.aje.a117699
   Xu Y, 2011, J DIABETES, V3, P38, DOI 10.1111/j.1753-0407.2010.00111.x
   Zoppini G, 2009, OBESITY, V17, P370, DOI 10.1038/oby.2008.544
NR 26
TC 6
Z9 7
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1047-2797
EI 1873-2585
J9 ANN EPIDEMIOL
JI Ann. Epidemiol.
PD DEC
PY 2012
VL 22
IS 12
BP 876
EP 880
DI 10.1016/j.annepidem.2012.09.012
PG 5
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 052XA
UT WOS:000312232400008
PM 23110960
DA 2025-06-11
ER

PT J
AU Santiago, E
   Climent, B
   Muñoz, M
   García-Sacristán, A
   Rivera, L
   Prieto, D
AF Santiago, Elvira
   Climent, Belen
   Munoz, Mercedes
   Garcia-Sacristan, Albino
   Rivera, Luis
   Prieto, Dolores
TI Hydrogen peroxide activates store-operated Ca<SUP>2+</SUP> entry in
   coronary arteries
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Article
ID ADRENERGIC-RECEPTOR STIMULATION; CALCIUM INFLUX; INOSITOL
   1,4,5-TRISPHOSPHATE; OXIDATIVE STRESS; HYPERPOLARIZING FACTOR; REDOX
   REGULATION; CONCISE GUIDE; RELEASE; CHANNEL; OBESE
AB BACKGROUND AND PURPOSE
   Abnormal Ca2+ metabolism has been involved in the pathogenesis of vascular dysfunction associated with oxidative stress. Here, we have investigated the actions of H2O2 on store-operated Ca2+ (SOC) entry in coronary arteries and assessed whether it is impaired in arteries from a rat model of metabolic syndrome.
   EXPERIMENTAL APPROACH
   Simultaneous measurements of intracellular Ca2+ concentration and contractile responses were made in coronary arteries from Wistar and obese Zucker rats, mounted in microvascular myographs, and the effects of H2O2 were assessed.
   KEY RESULTS
   H2O2 raised intracellular Ca2+ concentrations, accompanied by simultaneous vasoconstriction that was markedly reduced in a Ca2+-free medium. Upon Ca2+ re-addition, a nifedipine-resistant sustained Ca2+ entry, not coupled to contraction, was obtained in endothelium-denuded coronary arteries. The effect of H2O2 on this voltage-independent Ca2+ influx was concentration-dependent, and high micromolar H2O2 concentrations were inhibitory and reduced SOC entry evoked by inhibition of the sarcoplasmic reticulum ATPase (SERCA). H2O2-induced increases in Fura signals were mimicked by Ba2+ and reduced by heparin, Gd3+ ions and by Pyr6, a selective inhibitor of the Orai1-mediated Ca2+ entry,. In coronary arteries from obese Zucker rats, intracellular Ca2+ mobilization and SOC entry activated by acute exposure to H2O2 were augmented and associated with local oxidative stress.
   CONCLUSION AND IMPLICATIONS
   H2O2 exerted dual concentration-dependent stimulatory/inhibitory effects on store-operated, IP3 receptor-mediated and Orai1-mediated Ca2+ entry, not coupled to vasoconstriction in coronary vascular smooth muscle. SOC entry activated by H2O2 was enhanced and associated with vascular oxidative stress in coronary arteries in metabolic syndrome.
C1 [Santiago, Elvira; Climent, Belen; Munoz, Mercedes; Garcia-Sacristan, Albino; Rivera, Luis; Prieto, Dolores] Univ Complutense Madrid, Fac Farm, Dept Fisiol, E-28040 Madrid, Spain.
C3 Complutense University of Madrid
RP Prieto, D (corresponding author), Univ Complutense Madrid, Fac Farm, Dept Fisiol, E-28040 Madrid, Spain.
EM dprieto@ucm.es
RI Rivera de los Arcos, Luis/T-2247-2018; Climent, Belen/P-2416-2015;
   PRIETO, DOLORES/S-8172-2018
OI Rivera de los Arcos, Luis/0000-0002-0187-707X; Climent,
   Belen/0000-0003-0852-9227; PRIETO, DOLORES/0000-0001-7049-5991; Munoz
   Picos, Mercedes/0000-0002-1679-9588
FU MINECO, Spain [SAF 2012-31631]
FX This work was supported by grant SAF 2012-31631 from MINECO, Spain. We
   thank Francisco Puente and Manuel Perales for their expert technical
   assistance.
CR Alexander SPH, 2013, BRIT J PHARMACOL, V170, P1607, DOI 10.1111/bph.12447
   Alexander SPH, 2013, BRIT J PHARMACOL, V170, P1582, DOI 10.1111/bph.12446
   Az-ma T, 1999, BRIT J PHARMACOL, V126, P1462, DOI 10.1038/sj.bjp.0702438
   Berra-Romani R, 2008, AM J PHYSIOL-CELL PH, V295, pC779, DOI 10.1152/ajpcell.00173.2008
   Bogeski I, 2011, CELL CALCIUM, V50, P407, DOI 10.1016/j.ceca.2011.07.006
   Bogeski I, 2010, SCI SIGNAL, V3, DOI 10.1126/scisignal.2000672
   Chaplin NL, 2012, AM J PHYSIOL-CELL PH, V302, pC1382, DOI 10.1152/ajpcell.00222.2011
   Conti M, 2004, AM J PHYSIOL-REG I, V286, pR793, DOI 10.1152/ajpregu.00521.2002
   Contreras C, 2013, J SEX MED, V10, P2141, DOI 10.1111/jsm.12234
   Dröge W, 2002, PHYSIOL REV, V82, P47, DOI 10.1152/physrev.00018.2001
   Du WL, 2005, CHEST, V128, p556S, DOI 10.1378/chest.128.6_suppl.556S
   ELLIOTT SJ, 1989, J BIOL CHEM, V264, P3806
   Ellis E, 2003, BRIT J PHARMACOL, V140, P1193, DOI 10.1038/sj.bjp.0705549
   Flemming R, 2002, J PHYSIOL-LONDON, V543, P455, DOI 10.1113/jphysiol.2002.023366
   Florea SM, 2008, CELL CALCIUM, V43, P405, DOI 10.1016/j.ceca.2007.07.005
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Grupe M, 2010, CELL CALCIUM, V48, P1, DOI 10.1016/j.ceca.2010.05.005
   Hawkins BJ, 2010, J CELL BIOL, V190, P391, DOI 10.1083/jcb.201004152
   Hool LC, 2002, CIRC RES, V91, P601, DOI 10.1161/01.RES.0000035528.00678.D5
   Hool LC, 2000, CIRC RES, V87, P1164, DOI 10.1161/01.RES.87.12.1164
   Hu QH, 2000, J BIOL CHEM, V275, P15749, DOI 10.1074/jbc.M000381200
   Hu QH, 1998, CIRCULATION, V97, P268, DOI 10.1161/01.CIR.97.3.268
   Jardin I, 2008, J BIOL CHEM, V283, P25296, DOI 10.1074/jbc.M802904200
   Kilkenny C, 2011, J CEREBR BLOOD F MET, V31, P991, DOI 10.1111/j.1476-5381.2010.00872.x
   Kuster GM, 2010, FREE RADICAL BIO MED, V48, P1182, DOI 10.1016/j.freeradbiomed.2010.01.038
   Lancel S, 2010, CIRC RES, V107, P228, DOI 10.1161/CIRCRESAHA.110.217570
   Li J, 2011, BRIT J PHARMACOL, V164, P382, DOI 10.1111/j.1476-5381.2011.01368.x
   Lin MJ, 2007, AM J PHYSIOL-LUNG C, V292, pL1598, DOI 10.1152/ajplung.00323.2006
   Linde CI, 2012, AM J PHYSIOL-HEART C, V302, pH611, DOI 10.1152/ajpheart.00950.2011
   Lock JT, 2012, J PHYSIOL-LONDON, V590, P3431, DOI [10.1113/jphysiol.2012.230656, 10.1113/jphysiol.2012.232645]
   Matoba T, 2003, ARTERIOSCL THROM VAS, V23, P1224, DOI 10.1161/01.ATV.0000078601.79536.6C
   McGrath JC, 2010, BRIT J PHARMACOL, V160, P1573, DOI 10.1111/j.1476-5381.2010.00873.x
   Miura H, 2003, CIRC RES, V92, pE31, DOI 10.1161/01.RES.0000054200.44505.AB
   MULVANY MJ, 1977, CIRC RES, V41, P19, DOI 10.1161/01.RES.41.1.19
   Muñoz M, 2015, FREE RADICAL BIO MED, V84, P77, DOI 10.1016/j.freeradbiomed.2015.03.024
   Nunes P, 2014, ANTIOXID REDOX SIGN, V21, P915, DOI 10.1089/ars.2013.5615
   Ong HL, 2007, J BIOL CHEM, V282, P9105, DOI 10.1074/jbc.M608942200
   Parekh AB, 1995, J PHYSIOL-LONDON, V489, P377, DOI 10.1113/jphysiol.1995.sp021058
   Parekh AB, 2005, PHYSIOL REV, V85, P757, DOI 10.1152/physrev.00057.2003
   Parekh AB, 2006, PFLUG ARCH EUR J PHY, V453, P303, DOI 10.1007/s00424-006-0089-y
   Pawson AJ, 2014, NUCLEIC ACIDS RES, V42, pD1098, DOI 10.1093/nar/gkt1143
   Potier M, 2009, FASEB J, V23, P2425, DOI 10.1096/fj.09-131128
   Pourmahram GE, 2008, FREE RADICAL BIO MED, V45, P1468, DOI 10.1016/j.freeradbiomed.2008.08.020
   Redondo PC, 2004, BIOCHEM PHARMACOL, V67, P1065, DOI 10.1016/j.bcp.2003.10.028
   Redondo PC, 2004, BIOCHEM PHARMACOL, V67, P491, DOI 10.1016/j.bcp.2003.09.031
   Roos J, 2005, J CELL BIOL, V169, P435, DOI 10.1083/jcb.200502019
   Saitoh SI, 2007, AM J PHYSIOL-HEART C, V293, pH3720, DOI 10.1152/ajpheart.00436.2007
   Saitoh SI, 2006, ARTERIOSCL THROM VAS, V26, P2614, DOI 10.1161/01.ATV.0000249408.55796.da
   Saleem H, 2014, BRIT J PHARMACOL, V171, P3298, DOI 10.1111/bph.12685
   Santiago E, 2013, FREE RADICAL BIO MED, V60, P136, DOI 10.1016/j.freeradbiomed.2013.02.014
   Schleifer H, 2012, BRIT J PHARMACOL, V167, P1712, DOI 10.1111/j.1476-5381.2012.02126.x
   Serpillon S, 2009, AM J PHYSIOL-HEART C, V297, pH153, DOI 10.1152/ajpheart.01142.2008
   Shimokawa H, 2010, PFLUG ARCH EUR J PHY, V459, P915, DOI 10.1007/s00424-010-0790-8
   Snetkov VA, 2003, BRIT J PHARMACOL, V140, P97, DOI 10.1038/sj.bjp.0705408
   Sun L, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025432
   Touyz RM, 2005, ANTIOXID REDOX SIGN, V7, P1302, DOI 10.1089/ars.2005.7.1302
   Trebak M, 2010, ANTIOXID REDOX SIGN, V12, P657, DOI 10.1089/ars.2009.2842
   Vig M, 2006, SCIENCE, V312, P1220, DOI 10.1126/science.1127883
   Villalba N, 2008, AM J PHYSIOL-HEART C, V294, pH1923, DOI 10.1152/ajpheart.01221.2007
   Villalba N, 2007, AM J PHYSIOL-HEART C, V292, pH1157, DOI 10.1152/ajpheart.01034.2006
   Villalba N, 2009, AM J PHYSIOL-HEART C, V297, pH696, DOI 10.1152/ajpheart.01308.2008
   Viola HM, 2007, CIRC RES, V100, P1036, DOI 10.1161/01.RES.0000263010.19273.48
   Wong PS, 2014, PHARMACOL RES, V90, P25, DOI 10.1016/j.phrs.2014.09.004
   Yada T, 2003, CIRCULATION, V107, P1040, DOI 10.1161/01.CIR.0000050145.25589.65
   Yada T, 2007, J AM COLL CARDIOL, V50, P1272, DOI 10.1016/j.jacc.2007.05.039
   Zheng Y, 2005, REDOX REP, V10, P29, DOI 10.1179/135100005X21660
NR 66
TC 19
Z9 20
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD NOV
PY 2015
VL 172
IS 22
BP 5318
EP 5332
DI 10.1111/bph.13322
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CX0RB
UT WOS:000365403200008
PM 26478127
OA Green Published
DA 2025-06-11
ER

PT J
AU Khan, MAH
   Neckár, J
   Haines, J
   Imig, JD
AF Khan, Md. Abdul Hye
   Neckar, Jan
   Haines, Jasmine
   Imig, John D.
TI Azilsartan Improves Glycemic Status and Reduces Kidney Damage in Zucker
   Diabetic Fatty Rats
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
DE azilsartan medoxomil; blood pressure; hypertension; inflammation; kidney
   injury; oxidative stress; type 2 diabetes
ID STAGE RENAL-DISEASE; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; RECEPTOR
   ANTAGONIST; METABOLIC SYNDROME; ANGIOTENSIN; BLOCKADE; IRBESARTAN;
   GLUCOSE; INJURY
AB BACKGROUND
   Azilsartan medoxomil (AZL-M), an angiotensin II receptor blocker, demonstrates antihypertensive and organ protective effects in hypertension. We investigated the efficacy of AZL-M to ameliorate metabolic syndrome and kidney damage associated with type 2 diabetes using Zucker diabetic fatty (ZDF) rats.
   METHODS
   ZDF rats were treated with vehicle or AZL-M for 8 weeks. Zucker diabetic lean (ZDL) rats were used as controls. Urine and plasma samples were collected for biochemical analysis, and kidney tissues were used for histopathological and immunohistopathological examination at the end of the 8-week protocol.
   RESULTS
   ZDF rats were diabetic with hyperglycemia and impaired glucose tolerance, and AZL-M ameliorated the diabetic phenotype. ZDF rats were hypertensive compared with ZDL rats (181 +/- 6 vs. 129 +/- 7 mm Hg), and AZL-M decreased blood pressure in ZDF rats (116 +/- 7 mm Hg). In ZDF rats, there was marked renal damage with elevated proteinuria, albuminuria, nephrinuria, 2-4-fold higher tubular cast formation, and glomerular injury compared with ZDL rats. AZL-M treatment reduced renal damage in ZDF rats. ZDF rats demonstrated renal inflammation and oxidative stress with elevated urinary monocyte chemoattractant protein 1 excretion, renal infiltration of macrophages, and elevated kidney malondialdehyde levels. AZL-M reduced oxidative stress and inflammation in ZDF rats.
   CONCLUSIONS
   Overall, we demonstrate that AZL-M attenuates kidney damage in type 2 diabetes. We further demonstrate that anti-inflammatory and antioxidative activities of AZL-M contribute to its kidney protective action.
C1 [Khan, Md. Abdul Hye; Neckar, Jan; Haines, Jasmine; Imig, John D.] Med Coll Wisconsin, Dept Pharmacol & Toxicol, Milwaukee, WI 53226 USA.
   [Neckar, Jan] Acad Sci Czech Republ, Inst Physiol, Prague, Czech Republic.
   [Imig, John D.] Med Coll Wisconsin, Ctr Cardiovasc, Milwaukee, WI 53226 USA.
C3 Medical College of Wisconsin; Czech Academy of Sciences; Institute of
   Physiology of the Czech Academy of Sciences; Medical College of
   Wisconsin
RP Imig, JD (corresponding author), Med Coll Wisconsin, Dept Pharmacol & Toxicol, Milwaukee, WI 53226 USA.
EM jdimig@mcw.edu
RI ; Neckar, Jan/C-6645-2012
OI Khan, Md Abdul Hye/0000-0001-5940-9300; Imig, John/0000-0002-9668-2899;
   Neckar, Jan/0000-0002-1187-9992
FU Takeda Pharmaceuticals USA; Midwest Affiliate of the American Heart
   Association
FX We acknowledge technical assistance provided by Katherine A. Walsh and
   Priyanka Nervatla from the Department of Pharmacology & Toxicology,
   Medical College of Wisconsin. These works were supported by a grant from
   Takeda Pharmaceuticals USA. Md. Abdul Hye Khan is a recipient of
   Postdoctoral Fellowship from the Midwest Affiliate of the American Heart
   Association.
CR Benson SC, 2004, HYPERTENSION, V43, P993, DOI 10.1161/01.HYP.0000123072.34629.57
   Bonora E, 2006, ANN MED, V38, P64, DOI 10.1080/07853890500401234
   Brenner BM, 2001, NEW ENGL J MED, V345, P861, DOI 10.1056/NEJMoa011161
   Burnier M, 2006, J HYPERTENS, V24, P11, DOI 10.1097/01.hjh.0000191244.91314.9d
   Ceriello A, 2005, CIRCULATION, V111, P2518, DOI 10.1161/01.CIR.0000165070.46111.9F
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   Coimbra TM, 2000, KIDNEY INT, V57, P167, DOI 10.1046/j.1523-1755.2000.00836.x
   Coppo R, 2007, J AM SOC NEPHROL, V18, P1880, DOI 10.1681/ASN.2006040347
   Ferreira L, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/592760
   Fliser D, 2004, CIRCULATION, V110, P1103, DOI 10.1161/01.CIR.0000140265.21608.8E
   Forcheron F, 2009, CARDIOVASC DIABETOL, V8, DOI 10.1186/1475-2840-8-16
   Friedman EA, 2007, NEPHROL DIAL TRANSPL, V22, P681, DOI 10.1093/ndt/gfl735
   Gassler N, 2001, KIDNEY INT, V60, P106, DOI 10.1046/j.1523-1755.2001.00777.x
   Gray SP, 2011, NAT REV NEPHROL, V7, P71, DOI 10.1038/nrneph.2010.176
   Hoshi S, 2002, LAB INVEST, V82, P25, DOI 10.1038/labinvest.3780392
   Iwai M, 2007, AM J HYPERTENS, V20, P579, DOI 10.1016/j.amjhyper.2006.12.010
   Janiak P, 2006, EUR J PHARMACOL, V534, P271, DOI 10.1016/j.ejphar.2006.01.032
   Jiao B, 2011, BIOSCI TRENDS, V5, P173, DOI 10.5582/bst.2011.v5.4.173
   Kinoshita Y, 2011, TRANSL RES, V158, P235, DOI 10.1016/j.trsl.2011.05.003
   Komers R, 2000, EXPERT OPIN INV DRUG, V9, P2601, DOI 10.1517/13543784.9.11.2601
   Kurtz TW, 2012, VASC HEALTH RISK MAN, V8, P133, DOI 10.2147/VHRM.S22595
   Lehmann R, 2000, CLIN CHIM ACTA, V297, P135, DOI 10.1016/S0009-8981(00)00240-0
   Lewis EJ, 2001, NEW ENGL J MED, V345, P851, DOI 10.1056/NEJMoa011303
   Marchant Karen, 2008, Br J Nurs, V17, P356
   Mizuno M, 2002, HYPERTENS RES, V25, P271, DOI 10.1291/hypres.25.271
   Moser Marvin, 2004, J Clin Hypertens (Greenwich), V6, P4, DOI 10.1111/j.1524-6175.2004.03830.x
   Nakagawa T, 2011, NAT REV NEPHROL, V7, P36, DOI 10.1038/nrneph.2010.152
   PURVES RD, 1992, J PHARMACOKINET BIOP, V20, P211, DOI 10.1007/BF01062525
   Raptis AE, 2001, EXP CLIN ENDOCR DIAB, V109, pS424, DOI 10.1055/s-2001-18600
   Rossing Peter, 2006, Curr Diab Rep, V6, P479, DOI 10.1007/s11892-006-0083-y
   Shimamura M, 2011, EXP THER MED, V2, P957, DOI 10.3892/etm.2011.307
   Singh AK, 2013, CURR OPIN NEPHROL HY, V22, P198, DOI 10.1097/MNH.0b013e32835dda78
   Siwy J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051334
   Stewart JH, 2007, NEPHROLOGY, V12, P520, DOI 10.1111/j.1440-1797.2007.00830.x
   Taguchi I, 2013, HYPERTENS RES, V36, P608, DOI 10.1038/hr.2013.3
   Toblli JE, 2011, J HYPERTENS, V29, P1613, DOI 10.1097/HJH.0b013e328349064c
   Uehara Y, 1999, AM J HYPERTENS, V12, P21, DOI 10.1016/S0895-7061(98)00276-3
   Viberti G, 2002, CIRCULATION, V106, P672, DOI 10.1161/01.CIR.0000024416.33113.0A
   Wakai K, 2004, NEPHROL DIAL TRANSPL, V19, P2044, DOI 10.1093/ndt/gfh317
   Weyer C, 1999, J CLIN INVEST, V104, P787, DOI 10.1172/JCI7231
   Wild S, 2004, DIABETES CARE, V27, P1047, DOI 10.2337/diacare.27.5.1047
   Yamada S, 2011, CURR VASC PHARMACOL, V9, P158, DOI 10.2174/157016111794519318
NR 42
TC 16
Z9 16
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0895-7061
EI 1941-7225
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD AUG
PY 2014
VL 27
IS 8
BP 1087
EP 1095
DI 10.1093/ajh/hpu016
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AP7DL
UT WOS:000342237900020
PM 24598210
OA Bronze
DA 2025-06-11
ER

PT J
AU Luo, HW
   Deng, ZX
   Liu, L
   Shen, L
   Kou, H
   He, Z
   Ping, J
   Xu, D
   Ma, L
   Chen, LB
   Wang, H
AF Luo, Hanwen
   Deng, Zixin
   Liu, Lian
   Shen, Lang
   Kou, Hao
   He, Zheng
   Ping, Jie
   Xu, Dan
   Ma, Lu
   Chen, Liaobin
   Wang, Hui
TI Prenatal caffeine ingestion induces transgenerational neuroendocrine
   metabolic programming alteration in second generation rats
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Caffeine; Intrauterine growth retardation; Chronic stimulation;
   Hypothalamus-pituitary-adrenal axis; Glucose and lipid metabolism;
   Transgenerational inheritance
ID INTRAUTERINE GROWTH-RETARDATION; CARDIOVASCULAR RISK; FETAL; PREGNANCY;
   GLUCOSE; GLUCOCORTICOIDS; RESTRICTION; CONSUMPTION; EXPOSURE;
   ADIPONECTIN
AB Our previous studies have demonstrated that prenatal caffeine ingestion induces an increased susceptibility to metabolic syndrome with alterations of glucose and lipid metabolic phenotypes in adult first generation (F1) of intrauterine growth retardation (IUGR) rats, and the underlying mechanism is originated from a hypothalamic-pituitary-adrenal (HPA) axis-associated neuroendocrine metabolic programming alteration in utero. This study aims to investigate the transgenerational effects of this programming alteration in adult second generation (F2). Pregnant Wistar rats were administered with caffeine (120 mg/kg.d) from gestational day 11 until delivery. Four groups in F2 were set according to the cross-mating between control and caffeine-induced IUGR rats. F2 were subjected to a fortnight ice water swimming stimulus on postnatal month 4, and blood samples were collected before and after stress. Results showed that the majority of the activities of HPA axis and phenotypes of glucose and lipid metabolism were altered in F2. Particularly, comparing with the control group, caffeine groups had an enhanced corticosterone levels after chronic stress. Compared with before stress, the serum glucose levels were increased in some groups whereas the triglyceride levels were decreased. Furthermore, total cholesterol gain rates were enhanced but the high-density lipoprotein-cholesterol gain rates were decreased in most caffeine groups after stress. These transgenerational effects were characterized partially with gender and parental differences. Taken together, these results indicate that the reproductive and developmental toxicities and the neuroendocrine metabolic programming mechanism by prenatal caffeine ingestion have transgenerational effects in rats, which may help to explain the susceptibility to metabolic syndrome and associated diseases in F2. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Luo, Hanwen; Deng, Zixin; Liu, Lian; Shen, Lang; Kou, Hao; He, Zheng; Ping, Jie; Xu, Dan; Wang, Hui] Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China.
   [Luo, Hanwen; Chen, Liaobin] Wuhan Univ, Zhongnan Hosp, Dept Orthoped Surg, Wuhan 430071, Peoples R China.
   [Ping, Jie; Xu, Dan; Wang, Hui] Wuhan Univ, Res Ctr Food & Drug Evaluat, Wuhan 430071, Peoples R China.
   [Ma, Lu] Wuhan Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Wuhan 430071, Peoples R China.
C3 Wuhan University; Wuhan University; Wuhan University; Wuhan University
RP Chen, LB (corresponding author), Wuhan Univ, Zhongnan Hosp, Dept Orthoped Surg, Wuhan 430071, Peoples R China.
EM lbchen@whu.edu.cn; wanghui19@whu.edu.cn
FU National Natural Science Foundation of China [30830112, 81072709,
   81220108026, 81202240]; Chinese Ministry of Education [V200801];
   National Science & Technology Pillar Program of China [2013BAI12B01-3]
FX This work was supported by grants from the National Natural Science
   Foundation of China (Nos. 30830112, 81072709, 81220108026, 81202240),
   the Key Grant Project of the Chinese Ministry of Education (No.
   V200801), and the National Science & Technology Pillar Program of China
   (No. 2013BAI12B01-3).
CR Bertram C, 2008, J PHYSIOL-LONDON, V586, P2217, DOI 10.1113/jphysiol.2007.147967
   Boylan S, 2008, BMJ-BRIT MED J, V337, DOI 10.1136/bmj.a2332
   Brabant G, 2005, FASEB J, V19, P1048, DOI 10.1096/fj.04-2846fje
   Buchwald U, 2012, J MED PRIMATOL, V41, P231, DOI 10.1111/j.1600-0684.2012.00551.x
   Carrieri P, 2012, HEPATOLOGY, V56, P2010, DOI 10.1002/hep.25813
   Chang L, 2004, MOL MED, V10, P65, DOI 10.2119/2005-00029.Saltiel
   Chen M, 2011, DRUG DISCOV TODAY, V16, P1007, DOI 10.1016/j.drudis.2011.09.008
   Crudo A, 2013, ENDOCRINOLOGY, V154, P1168, DOI 10.1210/en.2012-1980
   Crudo A, 2012, ENDOCRINOLOGY, V153, P3269, DOI 10.1210/en.2011-2160
   D Xu, 2012, PLOS ONE, V7
   Ding GL, 2012, DIABETES, V61, P1133, DOI 10.2337/db11-1314
   Drake AJ, 2005, AM J PHYSIOL-REG I, V288, pR34, DOI 10.1152/ajpregu.00106.2004
   FENSTER L, 1991, AM J PUBLIC HEALTH, V81, P458, DOI 10.2105/AJPH.81.4.458
   Föcking M, 2005, BIOCHEM BIOPH RES CO, V337, P435, DOI 10.1016/j.bbrc.2005.09.067
   FORTIER I, 1993, AM J EPIDEMIOL, V137, P931, DOI 10.1093/oxfordjournals.aje.a116763
   Fowden AL, 2004, REPRODUCTION, V127, P515, DOI 10.1530/rep.1.00033
   Govorko D, 2012, BIOL PSYCHIAT, V72, P378, DOI 10.1016/j.biopsych.2012.04.006
   Grossniklaus U, 2013, NAT REV GENET, V14, P228, DOI 10.1038/nrg3435
   Guilbert J J, 2003, Educ Health (Abingdon), V16, P230
   Hoile SP, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0021668
   Hotta K, 2001, DIABETES, V50, P1126, DOI 10.2337/diabetes.50.5.1126
   Huang J, 2012, CLIN EXP PHARMACOL P, V39, P357, DOI 10.1111/j.1440-1681.2012.05676.x
   Iqbal M, 2012, ENDOCRINOLOGY, V153, P3295, DOI 10.1210/en.2012-1054
   Kanaoka Tsuyoshi, 2012, Ann Vasc Dis, V5, P36, DOI 10.3400/avd.oa.11.00068
   Kuczkowski KM, 2009, ARCH GYNECOL OBSTET, V280, P695, DOI 10.1007/s00404-009-0991-6
   Lejsková M, 2012, PHYSIOL RES, V61, P587, DOI 10.33549/physiolres.932313
   Lillycrop KA, 2005, J NUTR, V135, P1382, DOI 10.1093/jn/135.6.1382
   Liu L, 2012, TOXICOL LETT, V214, P307, DOI 10.1016/j.toxlet.2012.09.001
   Liu YS, 2012, TOXICOL APPL PHARM, V262, P205, DOI 10.1016/j.taap.2012.05.002
   Long NM, 2013, AM J OBSTET GYNECOL, V208, DOI 10.1016/j.ajog.2012.12.014
   López-Bermejo A, 2004, CLIN ENDOCRINOL, V60, P256, DOI 10.1046/j.1365-2265.2004.01977.x
   McCabe L, 2001, J NEUROENDOCRINOL, V13, P425, DOI 10.1046/j.1365-2826.2001.00649.x
   Morgan C, 2012, GEN COMP ENDOCR, V178, P441, DOI 10.1016/j.ygcen.2012.06.023
   Nyirenda MJ, 2001, J ENDOCRINOL, V170, P653, DOI 10.1677/joe.0.1700653
   Panchal SK, 2012, NUTRITION, V28, P1055, DOI 10.1016/j.nut.2012.02.013
   Peck JD, 2010, FOOD CHEM TOXICOL, V48, P2549, DOI 10.1016/j.fct.2010.06.019
   Phillips DIW, 2002, TRENDS ENDOCRIN MET, V13, P363, DOI 10.1016/S1043-2760(02)00696-3
   Radosavljevic Tatjana, 2005, Med Pregl, V58, P558, DOI 10.2298/MPNS0512558R
   Reagan-Shaw S, 2008, FASEB J, V22, P659, DOI 10.1096/fj.07-9574LSF
   Reynolds RM, 2010, J STEROID BIOCHEM, V122, P3, DOI 10.1016/j.jsbmb.2010.01.009
   Reynolds RM, 2001, J CLIN ENDOCR METAB, V86, P1149, DOI 10.1210/jc.86.3.1149
   Sengpiel V, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-42
   Sugiura C, 2012, J OBES, V2012, DOI 10.1155/2012/520510
   Szyf M, 2008, ENVIRON MOL MUTAGEN, V49, P46, DOI 10.1002/em.20357
   Tran M, 2013, J ENDOCRINOL, V217, P105, DOI 10.1530/JOE-12-0560
   van Dam R M, 2006, Ned Tijdschr Geneeskd, V150, P1821
   Wang LL, 2014, TOXICOL LETT, V224, P311, DOI 10.1016/j.toxlet.2013.11.006
   Weaver ICG, 2004, NAT NEUROSCI, V7, P847, DOI 10.1038/nn1276
   Xn D, 2012, TOXICOL APPL PHARM, V264, P395, DOI 10.1016/j.taap.2012.08.016
NR 49
TC 31
Z9 32
U1 1
U2 27
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD FEB 1
PY 2014
VL 274
IS 3
BP 383
EP 392
DI 10.1016/j.taap.2013.11.020
PG 10
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA AA5QR
UT WOS:000331155200003
PM 24321341
DA 2025-06-11
ER

PT J
AU Arnaud, AM
   Brister, TS
   Duckworth, K
   Foxworth, P
   Fulwider, T
   Suthoff, ED
   Werneburg, B
   Aleksanderek, I
   Reinhart, ML
AF Arnaud, Alix M.
   Brister, Teri . S.
   Duckworth, Ken
   Foxworth, Phyllis
   Fulwider, Tonya
   Suthoff, Ellison D.
   Werneburg, Brian
   Aleksanderek, Izabela
   Reinhart, Marcia L.
TI Impact of Major Depressive Disorder on Comorbidities: A Systematic
   Literature Review
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Review
ID CORONARY-HEART-DISEASE; ANTIDEPRESSANT MEDICATION;
   CARDIOVASCULAR-DISEASE; PSYCHOLOGICAL DISTRESS; METABOLIC SYNDROME;
   DIABETES-MELLITUS; MENTAL-ILLNESS; INCREASED RISK; FOLLOW-UP; LIFE-SPAN
AB Objective: To summarize the breadth of data exploring the relationship between major depressive disorder (MDD) and both the incidence and the disease course of a range of comorbidities.Data Sources: The authors searched MEDLINE, Embase, PsycINFO, Cochrane Database of Systematic Reviews, and several prespecified congresses. Searches included terms related to MDD and several comorbidity categories, restricted to those published in the English language from 2005 onward.StudySelection: Eligibility criteria included observational studies within North America and Europe that examined the covariate-adjusted impact of MDD on the risk and/or severity of comorbidities. A total of 6,811 articles were initially identified for screening.Data Extraction:Two investigators extracted data and assessed study quality.Results: In total, 199 articles were included. Depression was significantly (P<.05) associated with an increased incidence of dementia and Alzheimer's disease as well as cognitive decline in individuals with existing disease; increased incidence and worsening of cardiovascular disease/events (although mixed results were found for stroke); worsening of metabolic syndrome; increased incidence of diabetes, particularly among men, and worsening of existing diabetes; increased incidence of obesity, particularly among women; increased incidence and worsening of certain autoimmune diseases; increased incidence and severity of HIV/AIDS; and increased incidence of drug abuse and severity of both alcohol and drug abuse. Conclusions: The presence of MDD was identified as a risk factor for both the development and the worsening of a range of comorbidities.These results highlight the importance of addressing depression early in its course and the need for integrating mental and general health care.
C1 [Arnaud, Alix M.; Suthoff, Ellison D.; Werneburg, Brian] Sage Therapeut Inc, Cambridge, MA USA.
   [Brister, Teri . S.; Duckworth, Ken] Natl Alliance Mental Illness NAMI, Arlington, VA USA.
   [Foxworth, Phyllis] Depress & Bipolar Support Alliance, Chicago, IL USA.
   [Fulwider, Tonya] Mental Hlth Amer Ohio, Columbus, OH USA.
   [Aleksanderek, Izabela; Reinhart, Marcia L.] Tantalus Med Commun Ltd, Victoria, BC, Canada.
   [Suthoff, Ellison D.] 215 First St, Cambridge, MA 02142 USA.
RP Suthoff, ED (corresponding author), 215 First St, Cambridge, MA 02142 USA.
EM Ellison.Suthoff@sagerx.com
OI Arnaud, Alix/0000-0003-1193-4258
CR Amer Diabet Assoc, 2008, DIABETES CARE, V31, pS12, DOI 10.2337/dc08-S012
   American Psychiatric Association (APA), 2013, Diagnostic and Statistical Manual of Mental Disorders, V5th ed
   Andersson NW, 2015, PSYCHOL MED, V45, P3559, DOI 10.1017/S0033291715001488
   [Anonymous], MENTAL HLTH
   Atasoy S, 2018, J PSYCHOSOM RES, V115, P66, DOI 10.1016/j.jpsychores.2018.10.007
   Barlinn K, 2015, NEUROPSYCH DIS TREAT, V11, P1, DOI 10.2147/NDT.S63904
   BJORNTORP P, 1988, DIABETES METAB REV, V4, P615, DOI 10.1002/dmr.5610040607
   Block A, 2016, NORD J PSYCHIAT, V70, P611, DOI 10.1080/08039488.2016.1191535
   Blöchl M, 2019, J AFFECT DISORDERS, V247, P45, DOI 10.1016/j.jad.2018.12.082
   Brown LC, 2005, DIABETES CARE, V28, P1063, DOI 10.2337/diacare.28.5.1063
   Brunner EJ, 2014, EUR J PREV CARDIOL, V21, P340, DOI 10.1177/2047487314520785
   Butters Meryl A, 2008, Dialogues Clin Neurosci, V10, P345
   Campayo A, 2010, AM J PSYCHIAT, V167, P580, DOI 10.1176/appi.ajp.2009.09010038
   Cannon-Spoor HE, 2005, AM J GERIAT PSYCHIAT, V13, P312, DOI 10.1176/appi.ajgp.13.4.312
   Centers for Disease Control and Prevention, HEART DIS MENT HLTH
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   Cosgrove MP, 2008, OCCUP MED-OXFORD, V58, P7, DOI 10.1093/occmed/kqm105
   de Wit L, 2010, PSYCHIAT RES, V178, P230, DOI 10.1016/j.psychres.2009.04.015
   Diniz BS, 2013, BRIT J PSYCHIAT, V202, P329, DOI 10.1192/bjp.bp.112.118307
   Eriksson AK, 2008, DIABETIC MED, V25, P834, DOI 10.1111/j.1464-5491.2008.02463.x
   Fang F, 2010, MOVEMENT DISORD, V25, P1157, DOI 10.1002/mds.23092
   Farmer A, 2008, BRIT J PSYCHIAT, V192, P351, DOI 10.1192/bjp.bp.107.038380
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Greenberg PE, 2021, PHARMACOECONOMICS, V39, P653, DOI 10.1007/s40273-021-01019-4
   Greenberg PE, 2015, J CLIN PSYCHIAT, V76, P155, DOI 10.4088/JCP.14m09298
   Gross AL, 2010, CANCER CAUSE CONTROL, V21, P191, DOI 10.1007/s10552-009-9449-1
   Hamano T, 2015, J NEUROL NEUROSUR PS, V86, P319, DOI 10.1136/jnnp-2014-307616
   Han YY, 2016, J ALLERGY CLIN IMMUN, V4, P1
   Horberg MA, 2008, JAIDS-J ACQ IMM DEF, V47, P384, DOI 10.1097/QAI.0b013e318160d53e
   James SL, 2018, LANCET, V392, P1789, DOI [10.1016/s0140-6736(18)32335-3, 10.1016/S0140-6736(18)32335-3]
   Janszky I, 2007, BIOL PSYCHIAT, V62, P25, DOI 10.1016/j.biopsych.2006.08.039
   Johansson V, 2014, MULT SCLER J, V20, P1881, DOI 10.1177/1352458514540970
   Karakus MC, 2011, J BEHAV HEALTH SER R, V38, P373, DOI 10.1007/s11414-011-9234-2
   Katon WJ, 2010, J GEN INTERN MED, V25, P423, DOI 10.1007/s11606-009-1248-6
   Kivimaki M, 2010, DIABETES CARE, V33, P2611, DOI 10.2337/dc10-1187
   Köhler S, 2013, J AFFECT DISORDERS, V150, P63, DOI 10.1016/j.jad.2013.02.020
   Lam RW, 2016, CAN J PSYCHIAT, V61, P510, DOI 10.1177/0706743716659416
   Lasserre AM, 2017, MOL PSYCHIATR, V22, P1026, DOI 10.1038/mp.2016.178
   Laursen TM, 2016, J AFFECT DISORDERS, V193, P203, DOI 10.1016/j.jad.2015.12.067
   Luppa M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059246
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Lutgendorf SK, 2003, CLIN CANCER RES, V9, P4514
   Mallon L, 2005, DIABETES CARE, V28, P2762, DOI 10.2337/diacare.28.11.2762
   Markou A, 1998, NEUROPSYCHOPHARMACOL, V18, P135, DOI 10.1016/S0893-133X(97)00113-9
   Mezuk B, 2008, AM J PUBLIC HEALTH, V98, P1480, DOI 10.2105/AJPH.2007.126441
   Mezuk B, 2015, PSYCHOSOM MED, V77, P559, DOI 10.1097/PSY.0000000000000182
   Milaneschi Y, 2019, MOL PSYCHIATR, V24, P18, DOI 10.1038/s41380-018-0017-5
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Nabi H, 2010, INT J EPIDEMIOL, V39, P1016, DOI 10.1093/ije/dyq050
   National Institute for Health and Care Excellence, 2013, SOC CAR GUID MAN APP
   Nichols GA, 2011, DIABETOLOGIA, V54, P523, DOI 10.1007/s00125-010-1965-8
   Ownby RL, 2006, ARCH GEN PSYCHIAT, V63, P530, DOI 10.1001/archpsyc.63.5.530
   Owora AH, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000010252
   Pan A, 2011, STROKE, V42, P2770, DOI 10.1161/STROKEAHA.111.617043
   Pan A, 2010, ARCH INTERN MED, V170, P1884, DOI 10.1001/archinternmed.2010.356
   Patten SB, 2008, GEN HOSP PSYCHIAT, V30, P407, DOI 10.1016/j.genhosppsych.2008.05.001
   Patten SB, 2009, PSYCHOTHER PSYCHOSOM, V78, P182, DOI 10.1159/000209349
   Pinheiro MB, 2015, ARTHRIT CARE RES, V67, P1591, DOI 10.1002/acr.22619
   Prince JD, 2012, PSYCHIAT SERV, V63, P1032, DOI 10.1176/appi.ps.201100342
   Ransom J, 2019, VALUE HEALTH, V22, pS755
   Rotella F, 2013, J CLIN PSYCHIAT, V74, P32, DOI 10.4088/JCP.12r07922
   Sapolsky RM, 2000, ARCH GEN PSYCHIAT, V57, P925, DOI 10.1001/archpsyc.57.10.925
   Satin JR, 2009, CANCER-AM CANCER SOC, V115, P5349, DOI 10.1002/cncr.24561
   Sawa M, 2014, PSYCHOGERIATRICS, V14, P25, DOI 10.1111/psyg.12035
   Slavich GM, 2014, PSYCHOL BULL, V140, P774, DOI 10.1037/a0035302
   Surtees PG, 2008, NEUROLOGY, V70, P788, DOI 10.1212/01.wnl.0000304109.18563.81
   Surtees PG, 2008, AM J PSYCHIAT, V165, P515, DOI 10.1176/appi.ajp.2007.07061018
   Vallerand IA, 2018, RMD OPEN, V4, DOI 10.1136/rmdopen-2018-000670
   Van der Kooy K, 2007, INT J GERIATR PSYCH, V22, P613, DOI 10.1002/gps.1723
   Vancampfort D, 2015, DEPRESS ANXIETY, V32, P763, DOI 10.1002/da.22387
   Wang S, 2018, PROG NEURO-PSYCHOPH, V86, P186, DOI 10.1016/j.pnpbp.2018.05.025
   Wells GA, The Newcastle -Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta -analyses
   Wilson RS, 2016, NEUROPSYCHOLOGY, V30, P135, DOI 10.1037/neu0000223
   Wilson RS, 2011, AM J GERIAT PSYCHIAT, V19, P327, DOI 10.1097/JGP.0b013e31820119da
   Windle M, 2013, J AFFECT DISORDERS, V150, P895, DOI 10.1016/j.jad.2013.05.008
   World Health Organization, DEPR KEY FACTS
NR 76
TC 57
Z9 61
U1 6
U2 11
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD NOV-DEC
PY 2022
VL 83
IS 6
AR 21r14328
DI 10.4088/JCP.21r14328
PG 134
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA E9NI4
UT WOS:000978719100005
PM 36264099
OA Bronze
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Geoffroy, PA
   Godin, O
   Mahee, D
   Henry, C
   Aubin, V
   Azorin, JM
   Bougerol, T
   Courtet, P
   Gard, S
   Kahn, JP
   Passerieux, C
   Leboyer, M
   Bellivier, F
   Etain, B
AF Geoffroy, Pierre A.
   Godin, Ophelia
   Mahee, Diane
   Henry, Chantal
   Aubin, Valerie
   Azorin, Jean-Michel
   Bougerol, Thierry
   Courtet, Philippe
   Gard, Sebastien
   Kahn, Jean-Pierre
   Passerieux, Christine
   Leboyer, Marion
   Bellivier, Frank
   Etain, Bruno
CA FACE-BD coll
TI Seasonal pattern in bipolar disorders and cardio-vascular risk factors:
   A study from the FACE-BD cohort
SO CHRONOBIOLOGY INTERNATIONAL
LA English
DT Article
DE Bipolar disorder; circadian rhythms; depression; metabolic syndrome;
   seasonal affective disorder
ID MAJOR DEPRESSIVE DISORDER; METABOLIC SYNDROME; MELATONIN SUPPRESSION;
   CIRCADIAN-RHYTHMS; MENTAL-DISORDERS; MOOD DISORDERS; LIGHT THERAPY;
   METAANALYSIS; PREVALENCE; MORTALITY
AB Seasonal pattern (SP) and metabolic syndrome (MetS) are major contributors to poor outcome in bipolar disorders (BD). Patients with seasonal bipolar depression present increased appetite, carbohydrate cravings, weight gain, and hypersomnia, which can increase the development of MetS. MetS also appears to be associated with seasonal mood changes in the general population. This study examines whether a SP in BD is associated with an increased risk of MetS and its sub-components. One thousand four hundred and seventy-one outpatients with BD were systematically enrolled from 2009 to 2016. Inclusion required a disease duration of at least 5 years, with 486 (33%) patients with SP (SP+) and 985 (67%) without (SP-) according to the DSM IV-TR criteria. When using continuous measures of metabolic components, SP+ patients, as compared to SP-, suffered from higher levels for systolic blood pressure (p = 0.01), low-density lipoprotein cholesterol (p = 0.009), fasting glucose (p = 0.007), triglycerides levels (p = 0.03), a larger abdominal circumference (p = 0.02), and a higher body mass index (p = 0.07). In the covariance analysis, adjusted for gender, age, and bipolar subtype, as well as the number of depressive and hypomanic episode, SP+ patients had a significantly higher level of fasting glucose and higher systolic blood pressure. The frequency of MetS did not differ between groups (21.2% in SP- versus 23.9% in SP+). When using categorical definitions for abnormal metabolic components (International Diabetes Federation criteria), there were no differences between groups, except that SP+ patients were more overweight/obese as compared to SP- patients (55.03% versus 46.7%, respectively; p = 0.002) and tended to have more frequently high fasting glucose (18.2% versus 14.3%, respectively; p = 0.07). MetS was frequent in patients with BD, however not associated with SP. Patients with SP appeared more vulnerable to overweight/obesity and presented with higher levels of MetS subcomponents although these parameters were mainly in the normal range. All patients with BD should benefit from early screening and targeted management of cardio-vascular risk factors.
C1 [Geoffroy, Pierre A.; Mahee, Diane; Bellivier, Frank; Etain, Bruno] GH St Louis Lariboisiere F Widal, AP HP, Dept Psychiat & Med Addictol, Paris, France.
   [Geoffroy, Pierre A.; Bellivier, Frank; Etain, Bruno] Univ Paris Diderot, Sorbonne Paris Cite, Paris, France.
   [Geoffroy, Pierre A.; Bellivier, Frank; Etain, Bruno] INSERM, U1144, Paris, France.
   [Geoffroy, Pierre A.; Godin, Ophelia; Henry, Chantal; Aubin, Valerie; Azorin, Jean-Michel; Bougerol, Thierry; Courtet, Philippe; Gard, Sebastien; Kahn, Jean-Pierre; Passerieux, Christine; Leboyer, Marion; Bellivier, Frank; Etain, Bruno] Fdn FondaMental, Creteil, France.
   [Godin, Ophelia; Henry, Chantal; Leboyer, Marion] INSERM, U955, Equipe Psychiat Translat, Creteil, France.
   [Godin, Ophelia] Univ Paris 06, Sorbonne Univ, IPLESP, UMRS 1136, Paris, France.
   [Godin, Ophelia] INSERM, UMR S 1136, F-75013 Paris, France.
   [Henry, Chantal; Leboyer, Marion] Univ Paris Est, Fac Med, Creteil, France.
   [Leboyer, Marion] Hop Univ Henri Mondor, AP HP, DHU Pepsy, Pole Psychiat & Addictol, Creteil, France.
   [Henry, Chantal] Inst Pasteur, Unite Percept & Mem, Paris, France.
   [Aubin, Valerie] Ctr Hosp Princesse Grace, Serv Psychiat, Ave Pasteur, Monaco, Monaco.
   [Azorin, Jean-Michel] Hop St Marguerite, AP HM, Pole Psychiat, Marseille, France.
   [Azorin, Jean-Michel] Aix Marseille Univ, CNRS, CRN2M, UMR 7286, Marseille, France.
   [Bougerol, Thierry] CHU Grenoble, Clin Univ Psychiat, Grenoble, France.
   [Courtet, Philippe] Univ Montpellier I, CHRU Montpellier, Dept Urgence & Post Urgence Psychiat, INSERM,U1061, Montpellier, France.
   [Gard, Sebastien] Ctr Hosp Charles Perrens, Pole Psychiat Gen Univ, Bordeaux, France.
   [Kahn, Jean-Pierre] Univ Lorraine, CHRU Nancy, 1 Rue Docteur Archambault, Laxou, France.
   [Kahn, Jean-Pierre] Ctr Psychotherap Nancy, Pole Psychiat & Psychol Clin 6, 1 Rue Docteur Archambault, Laxou, France.
   [Kahn, Jean-Pierre] Univ Versailles St Quentin, Ctr Hosp Versailles, Serv Psychiat Adulte, Le Chesnay, France.
C3 Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Lariboisiere-Fernand-Widal - APHP; Hopital
   Universitaire Saint-Louis - APHP; Universite Paris Cite; Universite
   Paris Cite; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Sorbonne
   Universite; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Sorbonne Universite; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Paris-Est-Creteil-Val-de-Marne
   (UPEC); Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Henri-Mondor -
   APHP; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris;
   Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille;
   Aix-Marseille Universite; Centre National de la Recherche Scientifique
   (CNRS); CNRS - National Institute for Biology (INSB); CHU Grenoble
   Alpes; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes
   (UGA); Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite de Montpellier; CHU de Montpellier; Universite de
   Lorraine; CHU de Nancy; Universite Paris Saclay; Centre Hospitalier de
   Versailles
RP Geoffroy, PA (corresponding author), Pr Bellivier Hop Fernand Widal, Serv Psychiat Adulte, 200 Rue Faubourg St Denis, F-75475 Paris 10, France.
EM pierre.a.geoffroy@gmail.com
RI Leboyer, Marion/AAW-3648-2021; Etain, Bruno/L-6647-2017; Geoffroy,
   Pierre Alexis/D-9743-2011
OI Etain, Bruno/0000-0002-5377-1488; LEBOYER, Marion/0000-0001-5473-3697;
   Geoffroy, Pierre Alexis/0000-0001-9121-209X
FU AstraZeneca; Lundbeck; Menarini France; Otsuka; Sanofi-Aventis; Eli
   Lilly; Bristol-Myers Squibb; Janssen Cilag; Servier; Takeda; Teva; BMS;
   Bristol-Myers-Squibb; Janssen; Foundation FondaMental; Institut National
   de la Sante et de la Recherche Medicale (INSERM); AP-HP; Investissements
   d'Avenir program
FX Dr. P.A. Geoffroy has received travel awards or financial compensation
   from AstraZeneca, Lundbeck, Menarini France and Otsuka.r Pr. C. Henry
   has received honoraria and financial compensation as independent
   symposium speaker from Sanofi-Aventis, Lundbeck, AstraZeneca, Eli Lilly,
   Bristol-Myers Squibb.r Pr. J.M. Azorin received grants/research support,
   consulting fees and honoraria within the last three years from
   AstraZeneca, Janssen Cilag, Lundbeck, Otsuka, Servier, Takeda and Teva.r
   Dr. S. Gard has received honoraria and financial compensation as
   independent symposium speaker from Astra Zeneca, BMS and Otsuka.r Pr. J.
   P. Kahn has received travel awards and honoraria or financial
   compensation as independent symposium speaker from Lundbeck,
   Bristol-Myers-Squibb, Otsuka, Janssen.r Pr. M. Leboyer has received
   honoraria and financial compensation as an independent symposium speaker
   from AstraZeneca and Servier.r Pr. F. Bellivier has received honoraria
   and financial compensation as independent symposium speaker from
   Sanofi-Aventis, Lundbeck, AstraZeneca, Eli Lilly, Bristol-Myers Squibb
   and Servier.r Ass. Pr. B. Etain has received honoraria and financial
   compensation as independent symposium speaker from Sanofi-Aventis,
   Lundbeck, AstraZeneca, Eli Lilly, Bristol-Myers Squibb and Servier.r
   This research was supported by the Foundation FondaMental, Institut
   National de la Sante et de la Recherche Medicale (INSERM), AP-HP, and by
   the Investissements d'Avenir program managed by the ANR under reference
   ANR-11-IDEX-0004-02 and ANR-10-COHO-10-01. This funding source had no
   role in the study design, data collection, analysis, preparation of the
   manuscript, or decision to submit the manuscript for publication.
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Anderson G, 2016, CURR PHARM DESIGN, V22, P987, DOI 10.2174/1381612822666151214105314
   Andrew JE, 2001, J AFFECT DISORDERS, V62, P199, DOI 10.1016/S0165-0327(00)00148-8
   APA A.P. A., 2000, Diagnostic and statistical manual of mental disorders: DSM-IV, V4th
   Balkau B, 2003, DIABETES METAB, V29, P526, DOI 10.1016/S1262-3636(07)70067-8
   Baune BT, 2006, PSYCHOTHER PSYCHOSOM, V75, P319, DOI 10.1159/000093955
   Benard V, 2015, ENCEPHALE, V41, pS29, DOI 10.1016/S0013-7006(15)30004-X
   Blais FC, 1997, ENCEPHALE, V23, P447
   Boerman R, 2016, J CLIN PSYCHOPHARM, V36, P588, DOI 10.1097/JCP.0000000000000580
   Chesney E, 2014, WORLD PSYCHIATRY, V13, P153, DOI 10.1002/wps.20128
   Cheung A., 2012, Depression Research and Treatment, V2012, P1, DOI DOI 10.1155/2012/628434
   Crump C, 2013, JAMA PSYCHIAT, V70, P931, DOI 10.1001/jamapsychiatry.2013.1394
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   First M.B., 2016, User's Guide for the SCID-5-CV Structured Clinical Interview for DSM-5 Disorders: Clinical Version
   Geddes JR, 2013, LANCET, V381, P1672, DOI 10.1016/S0140-6736(13)60857-0
   Geoffroy PA, 2015, ENCEPHALE, V41, P527, DOI 10.1016/j.encep.2015.09.003
   Geoffroy PA, 2015, CURR PHARM DESIGN, V21, P3352, DOI 10.2174/1381612821666150619093448
   Geoffroy PA, 2014, J AFFECT DISORDERS, V168, P210, DOI 10.1016/j.jad.2014.07.002
   Geoffroy PA, 2013, CHRONOBIOL INT, V30, P1101, DOI 10.3109/07420528.2013.800091
   Gerber M, 2015, BRIT J NUTR, V113, pS4, DOI 10.1017/S0007114514003912
   Gignac A, 2015, J CLIN PSYCHIAT, V76, P1241, DOI 10.4088/JCP.14r09245
   Golden RN, 2005, AM J PSYCHIAT, V162, P656, DOI 10.1176/appi.ajp.162.4.656
   Hallam KT, 2006, PSYCHONEUROENDOCRINO, V31, P867, DOI 10.1016/j.psyneuen.2006.04.004
   HARDIN TA, 1991, J PSYCHIAT RES, V25, P75, DOI 10.1016/0022-3956(91)90001-Q
   Harvey AG, 2008, AM J PSYCHIAT, V165, P820, DOI 10.1176/appi.ajp.2008.08010098
   Hayes JF, 2015, ACTA PSYCHIAT SCAND, V131, P417, DOI 10.1111/acps.12408
   Henry C, 2015, AUST NZ J PSYCHIAT, V49, P898, DOI 10.1177/0004867415585582
   Kan JS, 2015, PSYCHIAT RES, V225, P540, DOI 10.1016/j.psychres.2014.11.051
   Kaneko I, 2015, FASEB J, V29, P4023, DOI 10.1096/fj.14-269811
   Karthick S, 2015, J PSYCHIATR PRACT, V21, P419, DOI 10.1097/PRA.0000000000000116
   Kennedy SH, 1996, PSYCHIAT RES, V63, P219, DOI 10.1016/0165-1781(96)02910-1
   Kessing LV, 2015, J AFFECT DISORDERS, V180, P142, DOI 10.1016/j.jad.2015.03.027
   Kessler RC, 2012, INT J METH PSYCH RES, V21, P169, DOI 10.1002/mpr.1359
   Kodesh A, 2012, SOC PSYCH PSYCH EPID, V47, P1775, DOI 10.1007/s00127-012-0478-9
   Laursen TM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0067133
   Leboyer M, 2012, J AFFECT DISORDERS, V141, P1, DOI 10.1016/j.jad.2011.12.049
   Magnusson A, 2005, CNS SPECTRUMS, V10, P625, DOI 10.1017/S1092852900019593
   Markus RP, 2013, INT J MOL SCI, V14, P10979, DOI 10.3390/ijms140610979
   Martin DJ, 2016, BRIT J PSYCHIAT, V208, P343, DOI 10.1192/bjp.bp.114.157784
   McClung CA, 2013, BIOL PSYCHIAT, V74, P242, DOI 10.1016/j.biopsych.2013.02.019
   McClung CA, 2011, EUR NEUROPSYCHOPHARM, V21, pS683, DOI 10.1016/j.euroneuro.2011.07.008
   MCINTYRE IM, 1989, J PINEAL RES, V6, P149
   Merikangas KR, 2007, ARCH GEN PSYCHIAT, V64, P543, DOI 10.1001/archpsyc.64.5.543
   Michalak EE, 2007, PSYCHOL MED, V37, P727, DOI 10.1017/S0033291706009378
   Misdrahi D, 2004, ENCEPHALE, V30, P409
   MONTGOMERY SA, 1979, BRIT J PSYCHIAT, V134, P382, DOI 10.1192/bjp.134.4.382
   Nurnberger JI, 2000, ARCH GEN PSYCHIAT, V57, P572, DOI 10.1001/archpsyc.57.6.572
   NURNBERGER JI, 1988, NEUROPSYCHOPHARMACOL, V1, P217, DOI 10.1016/0893-133X(88)90020-6
   Nussbaumer B, 2015, COCHRANE DB SYST REV, V11, DOI DOI 10.1002/14651858.CD011269.PUB2
   Pacchierotti C, 2001, FRONT NEUROENDOCRIN, V22, P18, DOI 10.1006/frne.2000.0202
   Pannier B, 2006, DIABETES METAB, V32, P467, DOI 10.1016/S1262-3636(07)70305-1
   Perlis RH, 2006, AM J PSYCHIAT, V163, P217, DOI 10.1176/appi.ajp.163.2.217
   Rintamäki R, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001482
   Romo-Nava F, 2014, BIPOLAR DISORD, V16, P410, DOI 10.1111/bdi.12196
   Rouillon F, 2015, ENCEPHALE, V41, P70, DOI 10.1016/j.encep.2014.12.003
   Stoleru D, 2007, CELL, V129, P207, DOI 10.1016/j.cell.2007.02.038
   Tu BP, 2006, NAT REV MOL CELL BIO, V7, P696, DOI 10.1038/nrm1980
   Uzoma HN, 2015, WORLD J PSYCHIATR, V5, P138, DOI 10.5498/wjp.v5.i1.138
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vancampfort D, 2013, AM J PSYCHIAT, V170, P265, DOI 10.1176/appi.ajp.2012.12050620
   Vázquez GH, 2015, EUR NEUROPSYCHOPHARM, V25, P1501, DOI 10.1016/j.euroneuro.2015.07.013
   Volkert J, 2016, EUR ARCH PSY CLIN N, V266, P225, DOI 10.1007/s00406-015-0657-2
   Walker ER, 2015, JAMA PSYCHIAT, V72, P334, DOI 10.1001/jamapsychiatry.2014.2502
   YOUNG RC, 1978, BRIT J PSYCHIAT, V133, P429, DOI 10.1192/bjp.133.5.429
   Zhang JF, 2006, NATURE, V439, P340, DOI 10.1038/nature04368
NR 66
TC 10
Z9 10
U1 0
U2 5
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0742-0528
EI 1525-6073
J9 CHRONOBIOL INT
JI Chronobiol. Int.
PY 2017
VL 34
IS 7
BP 845
EP 854
DI 10.1080/07420528.2017.1324472
PG 10
WC Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Life Sciences & Biomedicine - Other Topics; Physiology
GA FK3AO
UT WOS:000413356500002
PM 28537802
DA 2025-06-11
ER

PT J
AU Kim, MJ
   Kim, IW
AF Kim, Mi Joung
   Kim, In Woo
TI Self-rated health may be a predictor for metabolic syndrome and high
   hs-CRP prevalences in healthy adults in South Korea: Based on the 2015
   Korea National Health and Nutrition Examination Survey
SO NUTRITION RESEARCH
LA English
DT Article
DE Self-rated health; Metabolic syndrome; hs-CRP; Healthy adults; Perceived
   stress; Self-rated health; Metabolic syndrome; hs-CRP; Healthy adults;
   Perceived stress
ID C-REACTIVE PROTEIN; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY; ASSOCIATION;
   POPULATION; MORTALITY; OBESITY; RISK; INTERVENTIONS; OVERWEIGHT
AB Self-rated health (SRH), affected by sociodemographic and health-related behavioral factors, is related to metabolic syndrome (MetS) and high-sensitivity C-reactive protein (hs-CRP) levels. We hypothesized that SRH would have an independent effect on MetS and high hs-CRP incidence in healthy adults after adjusting for sociodemographic and health-related behavioral confounding factors. Data of 1545 healthy participants (aged 19-65 years; 654 men), selected from the 2015 Korean National Health and Nutritional Examination Survey, were cross-sectionally analyzed. The SRH levels significantly increased with higher income ( P < .05) and educational levels ( P < .01) and were associated with sex, job, marital status, smoking, physical activity, perceived body image, and weight change (all P < .05). The percentage of participants with "very high or high" perceived stress were significantly lower in the "very healthy" group (18.5%) than in the "unhealthy" group (49.7%). Dietary protein, calcium, and phosphorus intakes were significantly higher with better SRH levels. MetS prevalence was related to sex, educational level, job, marital status, smoking, high-intensity exercise, and aerobic exercise (all P < .05), with a 2.776 times higher risk in the "unhealthy" than in the "very healthy" group after adjusting for these confounders. High hs-CRP levels were related to marital status, smoking, weekly walking, and aerobic exercise (all P < .05), with its risk being 2.093 times higher in the "unhealthy" than in the "very healthy" group after adjusting for these confounders. Thus, SRH may be an independent predictor of MetS and high hsCRP levels and could be used for the development of a health promotion program in healthy adults.
C1 [Kim, Mi Joung; Kim, In Woo] Seoul Womens Univ, Coll Nat Sci, Dept Food & Nutr, Seoul, South Korea.
   [Kim, Mi Joung] Seoul Womens Univ, Coll Nat Sci, Dept Food & Nutr, 621 Hwarang Ro, Seoul 01797, South Korea.
C3 Seoul Women's University; Seoul Women's University
RP Kim, MJ (corresponding author), Seoul Womens Univ, Coll Nat Sci, Dept Food & Nutr, 621 Hwarang Ro, Seoul 01797, South Korea.
EM kmjoung@swu.ac.kr
RI Kim, Jong/G-7779-2012
CR Af Sillén U, 2005, SCAND J PUBLIC HEALT, V33, P183, DOI 10.1080/14034940410019235
   Anuurad E, 2003, J OCCUP HEALTH, V45, P335, DOI 10.1539/joh.45.335
   Baik I, 2008, AM J CLIN NUTR, V87, P1455, DOI 10.1093/ajcn/87.5.1455
   Baty HS, 2008, ANESTHESIOLOGY, V108, P506, DOI 10.1097/ALN.0b013e3181649314
   Botoseneanu A, 2015, J AM GERIATR SOC, V63, P222, DOI 10.1111/jgs.13205
   Chung JW, 2014, INT J CHRONIC OBSTR, V9, P795, DOI 10.2147/COPD.S61093
   Delpierre C, 2009, AM J PUBLIC HEALTH, V99, P1278, DOI 10.2105/AJPH.2008.147934
   DeSalvo KB, 2006, J GEN INTERN MED, V21, P267, DOI 10.1111/j.1525-1497.2005.00291.x
   Moral-García JE, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17041387
   Eriksen L, 2013, PREV MED, V57, P900, DOI 10.1016/j.ypmed.2013.09.024
   Ford ES, 2004, ATHEROSCLEROSIS, V173, P309, DOI 10.1016/j.atherosclerosis.2003.12.022
   Fröhlich M, 2000, DIABETES CARE, V23, P1835, DOI 10.2337/diacare.23.12.1835
   Greiner KA, 2004, SOC SCI MED, V59, P2303, DOI 10.1016/j.socscimed.2004.03.023
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hays JC, 1996, AM J GERIAT PSYCHIAT, V4, P188, DOI 10.1097/00019442-199622430-00002
   Herman KM, 2015, PREV MED, V73, P112, DOI 10.1016/j.ypmed.2015.01.030
   Hoeymans N, 1997, SOC SCI MED, V45, P1527, DOI 10.1016/S0277-9536(97)00089-0
   Kennedy BP, 1998, BRIT MED J, V317, P917
   Kim MK, 2014, ENDOCRINOL METAB, V29, P405, DOI 10.3803/EnM.2014.29.4.405
   Kim Mi Joung, 2008, Nutr Res Pract, V2, P107, DOI 10.4162/nrp.2008.2.2.107
   Kim MH, 2019, J CLIN MED, V8, DOI 10.3390/jcm8010034
   Ko JK, 2019, J AFFECT DISORDERS, V249, P319, DOI 10.1016/j.jad.2019.02.049
   Kwak HoKyung Kwak HoKyung, 2011, Korean Journal of Community Nutrition, V16, P672, DOI 10.5720/kjcn.2011.16.6.672
   Kwon K, 2016, ANN OCCUP ENVIRON ME, V28, DOI 10.1186/s40557-016-0126-z
   LEEHYEJIN, 2013, [Journal of the Korean Society of Food Science and Nutrition, 한국식품영양과학회지], V42, P1395
   Lim S, 2011, DIABETES CARE, V34, P1323, DOI 10.2337/dc10-2109
   Muldoon MF, 2006, J CLIN ENDOCR METAB, V91, P718, DOI 10.1210/jc.2005-1654
   Mulsant BH, 1997, J AM GERIATR SOC, V45, P954, DOI 10.1111/j.1532-5415.1997.tb02966.x
   Orchard TJ, 2005, ANN INTERN MED, V142, P611, DOI 10.7326/0003-4819-142-8-200504190-00009
   Qatanani M, 2007, GENE DEV, V21, P1443, DOI 10.1101/gad.1550907
   Rifai N, 2001, CLIN CHEM, V47, P403
   Santos AC, 2005, INT J OBESITY, V29, P1452, DOI 10.1038/sj.ijo.0803035
   Shanahan L, 2014, BRAIN BEHAV IMMUN, V36, P139, DOI 10.1016/j.bbi.2013.10.020
   Södergren M, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-551
   Södergren M, 2008, BMC PUBLIC HEALTH, V8, DOI 10.1186/1471-2458-8-352
   Song Y, 2019, KOREAN J FAM MED, V40, P116, DOI 10.4082/kjfm.17.0075
   Stone NJ, 2014, J AM COLL CARDIOL, V63, P2889, DOI 10.1016/j.jacc.2013.11.002
   Sygnowska E, 2012, KARDIOL POL, V70, P718
   Tu RP, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-027659
   Werch CE, 2007, J ADOLESCENT HEALTH, V41, P577, DOI 10.1016/j.jadohealth.2007.06.003
   WHO, 2012, GLOBAL TUBERCULOSIS REPORT 2012, P1
   Wrase J, 2006, COGN AFFECT BEHAV NE, V6, P53, DOI 10.3758/CABN.6.1.53
   Yoon Jihyun, 2017, [The Korean Journal of Food and Nutrition, 한국식품영양학회지], V30, P83, DOI 10.9799/ksfan.2017.30.1.083
   Yoon K, 2018, DIABETES METAB SYND, V12, P977, DOI 10.1016/j.dsx.2018.06.008
NR 44
TC 1
Z9 1
U1 0
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
EI 1879-0739
J9 NUTR RES
JI Nutr. Res.
PD JUN
PY 2022
VL 102
BP 71
EP 83
DI 10.1016/j.nutres.2022.03.003
EA APR 2022
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA 1J1WW
UT WOS:000797715500001
PM 35436679
DA 2025-06-11
ER

PT J
AU Ohnishi, T
   Bandow, K
   Kakimoto, K
   Machigashira, M
   Matsuyama, T
   Matsuguchi, T
AF Ohnishi, T.
   Bandow, K.
   Kakimoto, K.
   Machigashira, M.
   Matsuyama, T.
   Matsuguchi, T.
TI Oxidative stress causes alveolar bone loss in metabolic syndrome model
   mice with type 2 diabetes
SO JOURNAL OF PERIODONTAL RESEARCH
LA English
DT Article
DE diabetes; metabolic syndrome; endothelial nitric oxide synthase;
   reactive oxygen species
ID NITRIC-OXIDE SYNTHASE; ORTHODONTIC TOOTH MOVEMENT;
   NECROSIS-FACTOR-ALPHA; PERIODONTAL-DISEASE; ENDOTHELIAL-CELLS; ADULT
   PERIODONTITIS; INSULIN-RESISTANCE; MESSENGER-RNA; COMPLICATIONS;
   HYPERTENSION
AB Alveolar bone loss is caused by a host response to periodontal pathogens, and its progression is often enhanced by systemic conditions such as insulin resistance.Alveolar bone dehiscence has been observed in KK-A(y) mice, which are metabolic syndrome model mice with type 2 diabetes. The aim of this study was to investigate inducements responsible for alveolar bone dehiscence in the KK-A(y) mice.
   The expression of endothelial nitric oxide synthase in the mandibles of mice was detected using immunohistochemical staining and the reverse transcription-polymerase chain reaction. After administration of N-acetylcysteine, an antioxidant, to KK-A(y) mice, alveolar bone loss and the expression of endothelial nitric oxide synthase protein in gingival keratinocytes and of hydrogen peroxide concentrations in plasma, were analyzed. The effect of hydrogen peroxide on endothelial nitric oxide synthase expression in keratinocytes was examined using cultured keratinocytes.
   The expression of endothelial nitric oxide synthase was decreased in gingival keratinocytes from KK-A(y) mice compared with gingival keratinocytes from control mice. Administration of N-acetylcysteine to the mice restored endothelial nitric oxide synthase expression in the gingival keratinocytes, suppressed the alveolar bone loss and decreased the hydrogen peroxide concentrations in plasma without the improvement of obesity or diabetes. In vitro, stimulation with hydrogen peroxide decreased the expression level of endothelial nitric oxide synthase in cultured keratinocytes, which was restored by the addition of N-acetylcysteine.
   Reactive oxygen species, such as hydrogen peroxide, are responsible for the alveolar bone loss accompanied by decreased endothelial nitric oxide synthase expression in KK-A(y) mice. Therefore, we propose a working hypothesis that the generation of oxidative stress is an underlying systemic condition that enhances alveolar bone loss in periodontitis occurring as a complication of diabetes.
C1 [Ohnishi, T.; Bandow, K.; Kakimoto, K.; Matsuguchi, T.] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Dev Med, Div Biochem & Mol Dent, Kagoshima 890, Japan.
   [Machigashira, M.; Matsuyama, T.] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Periodontol, Kagoshima 890, Japan.
C3 Kagoshima University; Kagoshima University
RP Matsuguchi, T (corresponding author), Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Dev Med, Div Biochem & Mol Dent, 35-1 Sakuragaoka 8, Kagoshima 890, Japan.
EM tmatsugu@denta.hal.kagoshima-u.ac.jp
RI Matsuguchi, Tetsuya/HGU-0412-2022
OI Bandow, Kenjiro/0000-0002-1362-3034
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
   [17591943, 14571767, 19390474]; Grants-in-Aid for Scientific Research
   [19390474, 14571767, 17591943] Funding Source: KAKEN
FX This work was supported by a grant from the Ministry of Education,
   Culture, Sports, Science and Technology of Japan (Grants 17591943,
   14571767 and 19390474).
CR Aguirre J, 2001, AM J PATHOL, V158, P247, DOI 10.1016/S0002-9440(10)63963-6
   Aizawa-Abe M, 2000, J CLIN INVEST, V105, P1243, DOI 10.1172/JCI8341
   Allen RG, 2000, FREE RADICAL BIO MED, V28, P463, DOI 10.1016/S0891-5849(99)00242-7
   Anderson HDI, 2004, J BIOL CHEM, V279, P963, DOI 10.1074/jbc.M309552200
   Armour KE, 2001, ENDOCRINOLOGY, V142, P760, DOI 10.1210/en.142.2.760
   Balkau B, 1999, DIABETIC MED, V16, P442
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Chu Y, 2002, ARTERIOSCL THROM VAS, V22, P611, DOI 10.1161/01.ATV.0000012663.85364.FA
   D'Attillio M, 2004, ANGLE ORTHOD, V74, P851
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   GENCO RJ, 1992, J PERIODONTOL, V63, P338, DOI 10.1902/jop.1992.63.4s.338
   Gher M E, 1998, Dent Clin North Am, V42, P285
   GUARNIERI C, 1991, FREE RADICAL RES COM, V15, P11, DOI 10.3109/10715769109049120
   Hattori Y, 2003, DIABETOLOGIA, V46, P1543, DOI 10.1007/s00125-003-1224-3
   Hayashi K, 2002, AM J ORTHOD DENTOFAC, V122, P306, DOI 10.1067/mod.2002.126151
   Helfrich MH, 1997, J BONE MINER RES, V12, P1108, DOI 10.1359/jbmr.1997.12.7.1108
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   IWATSUKA H, 1970, ENDOCRINOL JAPON, V17, P23
   Karima M, 2005, J LEUKOCYTE BIOL, V78, P862, DOI 10.1189/jlb.1004583
   Kelly G S, 1998, Altern Med Rev, V3, P114
   Koya D, 1998, DIABETES, V47, P859, DOI 10.2337/diabetes.47.6.859
   Kuboki K, 2000, CIRCULATION, V101, P676, DOI 10.1161/01.CIR.101.6.676
   Lean JM, 2003, J CLIN INVEST, V112, P915, DOI 10.1172/JCI200318859
   Liu ZD, 2007, ACTA ORTHOP, V78, P46, DOI 10.1080/17453670610013411
   Nilsson J, 1998, ARTERIOSCL THROM VAS, V18, P1199, DOI 10.1161/01.ATV.18.8.1199
   Nishimura, 1969, Exp. Anim, V18, P147, DOI DOI 10.1538/EXPANIM1957.18.4_147
   Ohnishi T, 2000, J DENT RES, V79, P748, DOI 10.1177/00220345000790020801
   Pihlstrom BL, 2005, LANCET, V366, P1809, DOI 10.1016/S0140-6736(05)67728-8
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Ren YJ, 2002, J CLIN PERIODONTOL, V29, P757, DOI 10.1034/j.1600-051X.2002.290813.x
   Serio F G, 1999, Dent Clin North Am, V43, P37
   Shirazi M, 2002, ANGLE ORTHOD, V72, P211
   SHLOSSMAN M, 1990, J AM DENT ASSOC, V121, P532, DOI 10.14219/jada.archive.1990.0211
   Stallmeyer B, 2002, NITRIC OXIDE-BIOL CH, V6, P168, DOI 10.1006/niox.2001.0407
   TOKUNAGA K, 1986, NUCLEIC ACIDS RES, V14, P2829
   Touyz RM, 2004, HISTOCHEM CELL BIOL, V122, P339, DOI 10.1007/s00418-004-0696-7
   Tsai C, 2002, COMMUNITY DENT ORAL, V30, P182, DOI 10.1034/j.1600-0528.2002.300304.x
   TSAI CC, 1995, J PERIODONTOL, V66, P852, DOI 10.1902/jop.1995.66.10.852
   WILLIAMS RC, 1990, NEW ENGL J MED, V322, P373, DOI 10.1056/NEJM199002083220606
NR 39
TC 70
Z9 78
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3484
EI 1600-0765
J9 J PERIODONTAL RES
JI J. Periodont. Res.
PD FEB
PY 2009
VL 44
IS 1
BP 43
EP 51
DI 10.1111/j.1600-0765.2007.01060.x
PG 9
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA 392MH
UT WOS:000262306300006
PM 18973548
DA 2025-06-11
ER

PT J
AU Ailanen, L
   Ruohonen, ST
   Vähätalo, LH
   Tuomainen, K
   Eerola, K
   Salomäki-Myftari, H
   Röyttä, M
   Laiho, A
   Ahotupa, M
   Gylling, H
   Savontaus, E
AF Ailanen, Liisa
   Ruohonen, Suvi T.
   Vahatalo, Laura H.
   Tuomainen, Katja
   Eerola, Kim
   Salomaki-Myftari, Henriikka
   Roytta, Matias
   Laiho, Asta
   Ahotupa, Markku
   Gylling, Helena
   Savontaus, Eriika
TI The metabolic syndrome in mice overexpressing neuropeptide Y in
   noradrenergic neurons
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
DE neuropeptide Y; hepatic cholesterol synthesis oxidative stress; glucose
   metabolism; type 2 diabetes NAFLD; Y1-receptor
ID FATTY LIVER-DISEASE; VLDL-TRIGLYCERIDE SECRETION; IMPAIRED
   GLUCOSE-TOLERANCE; LEU7PRO POLYMORPHISM; CHOLESTEROL-SYNTHESIS;
   PREPRONEUROPEPTIDE-Y; INSULIN SENSITIVITY; DIABETIC-PATIENTS; INDUCED
   OBESITY; NERVOUS-SYSTEM
AB A gain-of-function polymorphism in human neuropeptide Y (NPY) gene (rs16139) associates with metabolic disorders and earlier onset of type 2 diabetes (T2D). Similarly, mice overexpressing NPY in noradrenergic neurons (OE-NPYDBH) display obesity and impaired glucose metabolism. In this study, the metabolic syndrome-like phenotype was characterized and mechanisms of impaired hepatic fatty acid, cholesterol and glucose metabolism in pre-obese (2-month-old) and obese (4-7-month-old) OE-NPYDBH mice were elucidated. Susceptibility to T2D was assessed by subjecting mice to high caloric diet combined with low-dose streptozotocin. Contribution of hepatic Y1-receptor to the phenotype was studied using chronic treatment with an Y1-receptor antagonist, BIBO3304. Obese OE-NPYDBH mice displayed hepatosteatosis and hypercholesterolemia preceded by decreased fatty acid oxidation and accelerated cholesterol synthesis. Hyperinsulinemia in early obese state inhibited pyruvate- and glucose-induced hyperglycemia, and deterioration of glucose metabolism of OE-NPYDBH mice developed with aging. Furthermore, streptozotocin induced T2D only in OE-NPYDBH mice. Hepatic inflammation was not morphologically visible, but upregulated hepatic anti-inflammatory pathways and increased 8-isoprostane combined with increased serum resistin and decreased interleukin 10 pointed to increased NPY-induced oxidative stress that may predispose OE-NPYDBH mice to insulin resistance. Chronic treatment with BIBO3304 did not improve the metabolic status of OE-NPYDBH mice. Instead, downregulation of beta-1-adrenoceptors suggests indirect actions of NPY via inhibition of sympathetic nervous system. In conclusion, changes in hepatic fatty acid, cholesterol and glucose metabolism favoring energy storage contribute to the development of NPY-induced metabolic syndrome, and the effect is likely mediated by changes in sympathetic nervous system activity.
C1 [Ailanen, Liisa; Ruohonen, Suvi T.; Vahatalo, Laura H.; Tuomainen, Katja; Eerola, Kim; Salomaki-Myftari, Henriikka; Savontaus, Eriika] Univ Turku, Inst Biomed, Turku, Finland.
   [Ailanen, Liisa; Ruohonen, Suvi T.; Vahatalo, Laura H.; Tuomainen, Katja; Eerola, Kim; Salomaki-Myftari, Henriikka; Savontaus, Eriika] Univ Turku, Turku Ctr Dis Modelling, Turku, Finland.
   [Ailanen, Liisa; Salomaki-Myftari, Henriikka] Univ Turku, Drug Res Doctoral Program, Turku, Finland.
   [Roytta, Matias] Univ Turku, Dept Pathol, Turku, Finland.
   [Roytta, Matias] Turku Univ Hosp, Turku, Finland.
   [Laiho, Asta] Univ Turku, Turku Ctr Biotechnol, Turku, Finland.
   [Laiho, Asta] Abo Akad Univ, Turku, Finland.
   [Ahotupa, Markku] Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland.
   [Gylling, Helena] Univ Helsinki, Dept Internal Med, Helsinki, Finland.
   [Gylling, Helena] Univ Helsinki, Cent Hosp, Helsinki, Finland.
   [Savontaus, Eriika] Turku Univ Hosp, Unit Clin Pharmacol, Turku, Finland.
C3 University of Turku; University of Turku; University of Turku;
   University of Turku; University of Turku; University of Turku; Abo
   Akademi University; University of Turku; University of Helsinki;
   University of Helsinki; Helsinki University Central Hospital; University
   of Turku
RP Savontaus, E (corresponding author), Turku Univ Hosp, Unit Clin Pharmacol, Turku, Finland.
EM eriika.savontaus@utu.fi
RI Tuomainen, Katja/AAG-4335-2019; Eerola, Kim/L-8819-2019; Ruohonen,
   Saku/MFI-3214-2025; Tuomainen, Katja/B-9286-2017
OI Tuomainen, Katja/0000-0003-3330-1670; Eerola, Kim/0000-0001-7882-2977;
   Savontaus, Eriika/0000-0003-3421-0367
FU Academy of Finland [130882/2009, 252441/2011]; Finnish Funding Agency
   for Innovation [40098/10]; State Funding for University-level Health
   Research; European Foundation for the Study of Diabetes; Finnish
   Foundation for Diabetes Research
FX This study was supported by Academy of Finland (130882/2009,
   252441/2011), the Finnish Funding Agency for Innovation (40098/10),
   State Funding for University-level Health Research, European Foundation
   for the Study of Diabetes and Finnish Foundation for Diabetes Research.
CR Ahotupa M, 1997, N-S ARCH PHARMACOL, V356, P297, DOI 10.1007/PL00005054
   ASSIMACOPOULOSJEANNET F, 1995, METABOLISM, V44, P228, DOI 10.1016/0026-0495(95)90270-8
   Bruinstroop E, 2012, DIABETES, V61, P1043, DOI 10.2337/db11-1142
   CABEZAS J., 2012, LIVER BIOPSY INDICAT, P161
   Cho YR, 2004, BIOCHEM BIOPH RES CO, V314, P773, DOI 10.1016/j.bbrc.2003.12.170
   CORONGIU FP, 1983, CHEM-BIOL INTERACT, V44, P289, DOI 10.1016/0009-2797(83)90056-X
   Dagdeviren S, 2016, MOL CELL BIOL, V36, P2956, DOI 10.1128/MCB.00181-16
   Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI23621
   Dozio E, 2007, MINI-REV MED CHEM, V7, P11, DOI 10.2174/138955707779317894
   EGAWA M, 1991, AM J PHYSIOL, V260, pR328, DOI 10.1152/ajpregu.1991.260.2.R328
   EKBLAD E, 1984, REGUL PEPTIDES, V8, P225, DOI 10.1016/0167-0115(84)90064-8
   Ferreira R, 2010, J BIOL CHEM, V285, P41921, DOI 10.1074/jbc.M110.164020
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   Fu YC, 2006, NUTR METAB, V3, DOI 10.1186/1743-7075-3-28
   Gao S, 2010, BIOCHEM BIOPH RES CO, V398, P619, DOI 10.1016/j.bbrc.2010.05.114
   Gilbert ER, 2011, EXP DIABETES RES, DOI 10.1155/2011/416254
   Gylling H, 2007, TRANSL RES, V149, P310, DOI 10.1016/j.trsl.2006.11.012
   Hundal RS, 2000, DIABETES, V49, P2063, DOI 10.2337/diabetes.49.12.2063
   Jaakkola U, 2009, EUR J CLIN NUTR, V63, P150, DOI 10.1038/sj.ejcn.1602964
   Kallio J, 2001, FASEB J, V15, P1242, DOI 10.1096/fj.00-0436fje
   Karvonen MK, 2006, J CLIN ENDOCR METAB, V91, P4664, DOI 10.1210/jc.2005-2083
   Karvonen MK, 1998, NAT MED, V4, P1434, DOI 10.1038/4027
   Karvonen MK, 2001, ATHEROSCLEROSIS, V159, P145, DOI 10.1016/S0021-9150(01)00468-3
   Kozarsky KF, 2000, ARTERIOSCL THROM VAS, V20, P721, DOI 10.1161/01.ATV.20.3.721
   Kuo LE, 2007, NAT MED, V13, P803, DOI 10.1038/nm1611
   Lee DH, 2003, CLIN CHEM, V49, P1358, DOI 10.1373/49.8.1358
   Lu HY, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/124958
   Machida Y, 2014, ENDOCRINOLOGY, V155, P4634, DOI 10.1210/en.2014-1537
   Masoudi-Kazemabad A, 2013, ANGIOLOGY, V64, P40, DOI 10.1177/0003319711435149
   Matsuzawa-Nagata N, 2008, METABOLISM, V57, P1071, DOI 10.1016/j.metabol.2008.03.010
   McTernan PG, 2003, J CLIN ENDOCR METAB, V88, P6098, DOI 10.1210/jc.2003-030898
   Mitchell GC, 2008, J NEUROSCI, V28, P14428, DOI 10.1523/JNEUROSCI.0343-08.2008
   NISHINA PM, 1994, METABOLISM, V43, P549, DOI 10.1016/0026-0495(94)90194-5
   Nordman S, 2005, EXP CLIN ENDOCR DIAB, V113, P282, DOI 10.1055/s-2005-865650
   Paredes-Turrubiarte G, 2016, CLIN EXP MED, V16, P193, DOI 10.1007/s10238-015-0347-4
   Pihlajamäki J, 2003, METABOLISM, V52, P643, DOI 10.1053/meta.2003.50098
   Rajala MW, 2003, J CLIN INVEST, V111, P225, DOI 10.1172/JCI200316521
   Roberts LJ, 2000, FREE RADICAL BIO MED, V28, P505, DOI 10.1016/S0891-5849(99)00264-6
   Ruohonen ST, 2008, DIABETES, V57, P1517, DOI 10.2337/db07-0722
   Ruohonen Suvi T, 2012, Int J Pept, V2012, P452524, DOI 10.1155/2012/452524
   Shetty GK, 2004, DIABETES CARE, V27, P2450, DOI 10.2337/diacare.27.10.2450
   Shi YC, 2013, CELL METAB, V17, P236, DOI 10.1016/j.cmet.2013.01.006
   Shi YC, 2011, OBESITY, V19, P2137, DOI 10.1038/oby.2011.99
   Sigala B, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0072928
   Simonen P, 2011, J HEPATOL, V54, P153, DOI 10.1016/j.jhep.2010.05.037
   Sousa-Ferreira L, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0022333
   Stafford JM, 2008, DIABETES, V57, P1482, DOI 10.2337/db07-1702
   Steppan CM, 2001, NATURE, V409, P307, DOI 10.1038/35053000
   Targher G, 2005, DIABETES, V54, P3541, DOI 10.2337/diabetes.54.12.3541
   Ueta CB, 2012, J ENDOCRINOL, V214, P359, DOI 10.1530/JOE-12-0155
   Ukkola O, 2007, EUR J CLIN NUTR, V61, P1102, DOI 10.1038/sj.ejcn.1602621
   Vähätalo LH, 2015, ACTA PHYSIOL, V213, P902, DOI 10.1111/apha.12436
   van Rossum CTM, 2006, INT J OBESITY, V30, P1522, DOI 10.1038/sj.ijo.0803314
   Vozarova B, 2002, DIABETES, V51, P1889, DOI 10.2337/diabetes.51.6.1889
   Wheway J, 2005, J EXP MED, V202, P1527, DOI 10.1084/jem.20051971
   Xie F, 2012, CELL PHYSIOL BIOCHEM, V29, P111, DOI 10.1159/000337592
   Yang L, 2009, J NEUROSCI, V29, P179, DOI 10.1523/JNEUROSCI.4379-08.2009
   Yeung EH, 2011, J CLIN ENDOCR METAB, V96, pE2055, DOI 10.1210/jc.2011-0195
   Yuzuriha H, 2003, INT J MOL MED, V11, P675
   Yuzuriha H, 2007, FASEB J, V21, P2108, DOI 10.1096/fj.06-7621com
   ZARJEVSKI N, 1993, ENDOCRINOLOGY, V133, P1753, DOI 10.1210/en.133.4.1753
   Zhang L, 2010, INT J OBESITY, V34, P357, DOI 10.1038/ijo.2009.232
   Zhang L, 2014, MOL METAB, V3, P581, DOI 10.1016/j.molmet.2014.05.001
   Zhu X, 2015, AM J PHYSIOL-HEART C, V309, pH1528, DOI 10.1152/ajpheart.00070.2015
NR 64
TC 19
Z9 20
U1 0
U2 1
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD JUL
PY 2017
VL 234
IS 1
BP 57
EP 72
DI 10.1530/JOE-16-0223
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EZ8MO
UT WOS:000404980300022
PM 28468933
OA Bronze
DA 2025-06-11
ER

PT J
AU Ittichaicharoen, J
   Apaijai, N
   Tanajak, P
   Sa-nguanmoo, P
   Chattipakorn, N
   Chattipakorn, SC
AF Ittichaicharoen, Jitjiroj
   Apaijai, Nattayaporn
   Tanajak, Pongpan
   Sa-nguanmoo, Piangkwan
   Chattipakorn, Nipon
   Chattipakorn, Siriporn C.
TI Impaired mitochondria and intracellular calcium transients in the
   salivary glands of obese rats
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE insulin; obesity; metabolic syndrome; salivary gland function;
   mitochondria
ID DIPEPTIDYL PEPTIDASE-4 INHIBITOR; INSULIN-RECEPTOR FUNCTION; ACTIVATED
   PROTEIN-KINASE; METABOLIC SYNDROME; SJOGRENS-SYNDROME; CARDIAC-FUNCTION;
   SECRETION; AQUAPORIN-5; STRESS; FLUID
AB Long-term consumption of a high-fat diet (HFD) causes not only obese-insulin resistance, but is also associated with mitochondrial dysfunction in several organs. However, the effect of obese-insulin resistance on salivary glands has not been investigated. We hypothesized that obese-insulin resistance induced by HFD impaired salivary gland function by reducing salivation, increasing inflammation, and fibrosis, as well as impairing mitochondrial function and calcium transient signaling. Male Wistar rats (200-220 g) were fed either a ND or an HFD (n = 8/group) for 16 weeks. At the end of week 16, salivary flow rates, metabolic parameters, and plasma oxidative stress were determined. Rats were then sacrificed and submandibular glands were removed to determine inflammation, fibrosis, apoptosis, mitochondrial function and dynamics, and intracellular calcium transient signaling. Long-term consumption of an HFD caused obese-insulin resistance and increased oxidative stress, fibrosis, inflammation, and apoptosis in the salivary glands. In addition, impaired mitochondrial function, as indicated by increased mitochondrial reactive oxygen species, mitochondrial membrane depolarization, and mitochondrial swelling in salivary glands and impaired intracellular calcium regulation, as indicated by a reduced intracellular calcium transient rising rate, decay rates, and amplitude of salivary acinar cells, were observed in HFD-fed rats. However, salivary flow rate and level of aquaporin 5 protein were not different between both groups. Although HFD consumption did not affect salivation, it caused obese-insulin resistance, leading to pathophysiological alteration of salivary glands, including impaired intracellular calcium transients, increased oxidative stress and inflammation, and salivary mitochondrial dysfunction.
C1 [Ittichaicharoen, Jitjiroj; Chattipakorn, Siriporn C.] Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Fac Med,Neurophysiol Unit,Dept Oral Biol & Diagno, Fac Dent,Cardiac Electrophysiol Res & Training Ct, Chiang Mai 50200, Thailand.
   [Apaijai, Nattayaporn] Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Fac Med, Cardiac Electrophysiol Res & Training Ctr,Neuroph, Chiang Mai 50200, Thailand.
   [Tanajak, Pongpan; Sa-nguanmoo, Piangkwan; Chattipakorn, Nipon] Chiang Mai Univ, Ctr Excellence Cardiac Elect Res, Fac Med,Neurophysiol Unit, Cardiac Electrophysiol Res & Training Ctr,Dept Ph, Chiang Mai 50200, Thailand.
C3 Chiang Mai University; Chiang Mai University; Chiang Mai University
RP Chattipakorn, SC (corresponding author), Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Fac Med,Neurophysiol Unit,Dept Oral Biol & Diagno, Fac Dent,Cardiac Electrophysiol Res & Training Ct, Chiang Mai 50200, Thailand.
EM scchattipakorn@gmail.com
RI Chattipakorn, Nipon/AAJ-4049-2021; Tanajak, Pongpan/ABB-2347-2020
OI Sa-nguanmoo, Piangkwan/0000-0002-4795-8473; Chattipakorn,
   Nipon/0000-0003-3026-718X; Chattipakorn, Siriporn/0000-0003-1677-7052
FU Thailand Research Fund [TRF-BRG 5780016]; National Research Council of
   Thailand; CMU 50th Anniversary grant by Chiang Mai University
   [PHD/021/2556]; NSTDA Research Chair Grant from the National Science and
   Technology Development Agency Thailand; Chiang Mai University Center of
   Excellence Award
FX This work was supported by Thailand Research Fund grant: TRF-BRG 5780016
   (S.C.C.); the National Research Council of Thailand (S.C.C.); a CMU 50th
   Anniversary grant by Chiang Mai University (PHD/021/2556; J.I. and
   S.C.C.); a NSTDA Research Chair Grant from the National Science and
   Technology Development Agency Thailand (N.C.), and a Chiang Mai
   University Center of Excellence Award (N.C.). The authors would like to
   thank Ms. Cicely Proctor for her editorial assistance.
CR Al-Rawi NH, 2011, DIABETES VASC DIS RE, V8, P22, DOI 10.1177/1479164110390243
   Ambudkar IS, 2014, CELL CALCIUM, V55, P297, DOI 10.1016/j.ceca.2014.02.009
   Ambudkar IS, 2000, CRIT REV ORAL BIOL M, V11, P4, DOI 10.1177/10454411000110010301
   Apaijai N, 2016, J ENDOCRINOL, V229, P245, DOI 10.1530/JOE-16-0096
   Apaijai N, 2013, BRIT J PHARMACOL, V169, P1048, DOI 10.1111/bph.12176
   Asari T, 2009, CLIN EXP PHARMACOL P, V36, P531, DOI 10.1111/j.1440-1681.2008.05104.x
   Ben-Ari Z, 2002, TRANSPLANTATION, V73, P1875, DOI 10.1097/00007890-200206270-00004
   Dodds MWJ, 1997, ORAL SURG ORAL MED O, V83, P465, DOI 10.1016/S1079-2104(97)90147-5
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   Fedirko NV, 2006, BBA-MOL BASIS DIS, V1762, P294, DOI 10.1016/j.bbadis.2005.12.002
   Frank S, 2001, DEV CELL, V1, P515, DOI 10.1016/S1534-5807(01)00055-7
   Gannot G, 2000, J RHEUMATOL, V27, P1905
   GOLDMAN JA, 1977, JAMA-J AM MED ASSOC, V237, P1582, DOI 10.1001/jama.237.15.1582
   Hall BE, 2010, LAB INVEST, V90, P543, DOI 10.1038/labinvest.2010.5
   Imai K, 1997, BIOCHEM J, V322, P809, DOI 10.1042/bj3220809
   Inthachai T, 2015, EXP PHYSIOL, V100, P667, DOI 10.1113/EP085108
   Jonsson MV, 2006, ARTHRITIS RHEUM, V54, P2300, DOI 10.1002/art.21945
   Kawakami A, 2007, J RHEUMATOL, V34, P1019
   Kitzinger HB, 2013, EUR SURG, V45, P80, DOI 10.1007/s10353-013-0196-x
   Lasisi T J, 2012, Niger J Physiol Sci, V27, P79
   Leask A, 2004, FASEB J, V18, P816, DOI 10.1096/fj.03-1273rev
   Lee MG, 2012, PHYSIOL REV, V92, P39, DOI 10.1152/physrev.00011.2011
   Lekawanvijit S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041281
   Ma TH, 1999, J BIOL CHEM, V274, P20071, DOI 10.1074/jbc.274.29.20071
   Marber MS, 2011, J MOL CELL CARDIOL, V51, P485, DOI 10.1016/j.yjmcc.2010.10.021
   Maria DA, 2013, INVEST NEW DRUG, V31, P493, DOI 10.1007/s10637-012-9871-1
   López-Pintor RM, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/4372852
   Martin SS, 2013, J AM COLL CARDIOL, V62, P732, DOI 10.1016/j.jacc.2013.01.079
   Matsuzaki T, 2012, ACTA HISTOCHEM CYTOC, V45, P251, DOI 10.1267/ahc.12018
   Melvin JE, 2005, ANNU REV PHYSIOL, V67, P445, DOI 10.1146/annurev.physiol.67.041703.084745
   Meurman JH, 1998, ORAL SURG ORAL MED O, V86, P69, DOI 10.1016/S1079-2104(98)90152-4
   Ni HM, 2015, REDOX BIOL, V4, P6, DOI 10.1016/j.redox.2014.11.006
   Park J, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023211
   Ping L, 2012, J RHEUMATOL, V39, P1256, DOI 10.3899/jrheum.110097
   Pintana H, 2013, J ENDOCRINOL, V218, P1, DOI 10.1530/JOE-12-0521
   Pipatpiboon N, 2013, EUR J NEUROSCI, V37, P839, DOI 10.1111/ejn.12088
   Pipatpiboon N, 2012, ENDOCRINOLOGY, V153, P329, DOI 10.1210/en.2011-1502
   Pratchayasakul W, 2011, LIFE SCI, V88, P619, DOI 10.1016/j.lfs.2011.02.003
   Prathibha KM, 2013, J CLIN DIAGN RES, V7, P1592, DOI 10.7860/JCDR/2013/5749.3232
   Pringle S, 2011, JOVE-J VIS EXP, DOI 10.3791/2484
   Proctor GB, 2014, MONOGR ORAL SCI, V24, P14, DOI 10.1159/000358781
   Rabol R, 2006, APPL PHYSIOL NUTR ME, V31, P675, DOI 10.1139/h06-071
   Pereira RMR, 2009, AUTOIMMUN REV, V8, P415, DOI 10.1016/j.autrev.2009.01.001
   Shikama Y, 2013, J DENT RES, V92, P540, DOI 10.1177/0022034513487378
   Sivasinprasasn S, 2015, AGE, V37, DOI 10.1007/s11357-015-9766-0
   Sripetehwandee J, 2014, ARCH MED RES, V45, P547, DOI 10.1016/j.arcmed.2014.09.002
   Tremblay M, 2011, J CAN DENT ASSOC, V77, P1
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Yamachika S, 2000, CLIN EXP RHEUMATOL, V18, P233
   Yarana C, 2012, LIFE SCI, V90, P808, DOI 10.1016/j.lfs.2012.04.004
   Zalewska A, 2013, ADV CLIN EXP MED, V22, P659
NR 51
TC 13
Z9 14
U1 0
U2 12
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD APR
PY 2017
VL 42
IS 4
BP 420
EP 429
DI 10.1139/apnm-2016-0545
PG 10
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA ER5KB
UT WOS:000398839400012
PM 28177730
DA 2025-06-11
ER

PT J
AU Tonello, L
   Oliveira-Silva, I
   Medeiros, AR
   Donato, ANA
   Schuch, FB
   Donath, L
   Boullosa, D
AF Tonello, Lais
   Oliveira-Silva, Iranse
   Medeiros, Andre Ricarte
   Alves Donato, Arthur Ney
   Schuch, Felipe Barreto
   Donath, Lars
   Boullosa, Daniel
TI Prediction of Depression Scores From Aerobic Fitness, Body Fatness,
   Physical Activity, and Vagal Indices in Non-exercising, Female Workers
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE depression; physical activity; autonomic control of HR; body
   composition; physical fitness; women
ID HEART-RATE-VARIABILITY; CARDIAC AUTONOMIC RECOVERY; CARDIORESPIRATORY
   FITNESS; BIPOLAR DISORDER; SEDENTARY BEHAVIOR; METABOLIC SYNDROME; MAJOR
   DEPRESSION; SYMPTOM SEVERITY; EXERCISE; PEOPLE
AB Background: Depression is associated with a decreased cardiorespiratory fitness, and physical activity [PA] levels, higher rates of obesity, and dysfunction in autonomic control of heart rate [HR]. However, these parameters were mostly recorded with indirect methods. Thus, the aim of the current study was to investigate the relationships between depression scores and objective measures of body fatness, autonomic indices (i.e. HRV and HRR), cardiorespiratory fitness and PA levels; and subsequently to present the best predictive models of depression scores for this population, based on these variables.
   Methods: Thirty-five non-exercising women (26-43 years; maximal oxygen consumption [VO(2)max] similar to 17.4-38.3 mL/kg/min) volunteered for participation in this study. All participants responded to the Beck Depression Inventory [DBI] and were evaluated for body mass index [BMI], percentage of body fat, sum of skinfolds, and VO(2)max. Subsequently, over four consecutive days, an orthostatic test and a submaximal exercise on a cycle ergometer were performed to record HRV and HRR, respectively. In addition, incidental PA was recorded during 5 consecutive days using accelerometers.
   Results: depression scores were related to VO(2)max (r = -0.446, p = 0.007) and the sum of skinfolds (r = 0.434, p = 0.009). Several stepwise multiple linear regression models were performed and only VO(2)max was revealed as an independent predictor of the Beck scores (beta = -0.446, R-2 = 0.199, p = 0.007).
   Conclusion: The present study revealed that VO(2)max and the sum of skinfolds were moderately related to depression scores, while VO(2)max was the only independent predictor of depression scores in female workers.
C1 [Tonello, Lais] Univ Gurupi, Educ Fis, Gurupi, Brazil.
   [Tonello, Lais; Medeiros, Andre Ricarte; Alves Donato, Arthur Ney] Univ Catolica Brasilia, Escola Saude & Med, Brasilia, DF, Brazil.
   [Oliveira-Silva, Iranse] UniEVANGEL Ctr Univ Anapolis, Educ Fis, Anapolis, Brazil.
   [Schuch, Felipe Barreto] Univ La Salle Canoas, Saude & Desenvolvimento Humano, Canoas, Brazil.
   [Donath, Lars] German Sport Univ Cologne, Dept Intervent Res Exercise Training, Cologne, Germany.
   [Boullosa, Daniel] James Cook Univ, Sport & Excercise Sci, Townsville, Qld, Australia.
C3 Universidade Catolica de Brasilia; German Sport University Cologne;
   James Cook University
RP Boullosa, D (corresponding author), James Cook Univ, Sport & Excercise Sci, Townsville, Qld, Australia.
EM daniel.boullosa@gmail.com
RI Boullosa, Daniel/U-3886-2019; Oliveira-Silva, Iranse/H-7046-2015;
   Medeiros, André/N-2438-2016; Schuch, Felipe/AAF-5028-2019; Schuch,
   Felipe/L-4620-2016
OI Schuch, Felipe/0000-0002-5190-4515; Boullosa,
   Daniel/0000-0002-8477-127X; Donath, Lars/0000-0001-6039-0141
FU ARM enjoy a PROSUP scholarship grant from CAPES; CNPQ [305131/2015-0]
FX LT and ARM enjoy a PROSUP scholarship grant from CAPES. DB enjoys a
   productivity research grant from CNPQ (305131/2015-0).
CR Adams D.J., 2015, BMJ Open Sport Exerc Med, V1, pe000036, DOI DOI 10.1136/BMJSEM-2015-000036
   Ainsworth BE, 2000, MED SCI SPORT EXER, V32, pS498, DOI 10.1097/00005768-200009001-00009
   [Anonymous], 2011, INT J BEHAV NUTR PHY
   [Anonymous], 2016, FRONT PHYSIOL, DOI DOI 10.3389/fphys.2015.00405
   [Anonymous], THESIS
   [Anonymous], BRAZ MAJ REG FED UN
   [Anonymous], GUID EX TEST PRESCR
   Ariyo AA, 2000, CIRCULATION, V102, P1773
   Barak OF, 2011, J SPORT SCI MED, V10, P369
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   Becofsky KM, 2015, AM J EPIDEMIOL, V181, P311, DOI 10.1093/aje/kwu330
   Benítez-Flores S, 2019, EUR J APPL PHYSIOL, V119, P1337, DOI 10.1007/s00421-019-04125-6
   Benítez-Flores S, 2018, KINESIOLOGY, V50, P137, DOI 10.26582/k.50.2.13
   Boettger S, 2009, PSYCHOSOM MED, V71, P519, DOI 10.1097/PSY.0b013e3181a55303
   Buchheit M, 2006, INT J SPORTS MED, V27, P697, DOI 10.1055/s-2005-872929
   Buchheit M, 2005, MED SCI SPORT EXER, V37, P1530, DOI 10.1249/01.mss.0000177556.05081.77
   Burton C, 2013, J AFFECT DISORDERS, V145, P21, DOI 10.1016/j.jad.2012.07.001
   Busch AM, 2016, MENT HEALTH PHYS ACT, V10, P68, DOI 10.1016/j.mhpa.2015.12.004
   Caldwell YT, 2018, INT J PSYCHOPHYSIOL, V131, P96, DOI 10.1016/j.ijpsycho.2018.01.001
   Carney RM, 2017, NAT REV CARDIOL, V14, DOI 10.1038/nrcardio.2016.181
   CASPERSEN CJ, 1985, PUBLIC HEALTH REP, V100, P126
   Chang HA, 2015, WORLD J BIOL PSYCHIA, V16, P351, DOI 10.3109/15622975.2015.1017606
   Chu IH, 2017, J ALTERN COMPLEM MED, V23, P310, DOI 10.1089/acm.2016.0135
   Cole CR, 1999, NEW ENGL J MED, V341, P1351, DOI 10.1056/NEJM199910283411804
   Danieli A, 2014, CLIN AUTON RES, V24, P53, DOI 10.1007/s10286-014-0225-2
   Davydov DM, 2007, PROG NEURO-PSYCHOPH, V31, P164, DOI 10.1016/j.pnpbp.2006.08.015
   de Sousa AFM, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00241
   Dishman RK, 2012, AM J PREV MED, V43, P361, DOI 10.1016/j.amepre.2012.06.011
   Ekkekakis P, 2015, MENT HEALTH PHYS ACT, V8, P21, DOI 10.1016/j.mhpa.2014.12.001
   Elderon L, 2013, PROG CARDIOVASC DIS, V55, P511, DOI 10.1016/j.pcad.2013.03.010
   Faurholt-Jepsen M, 2017, NEUROSCI BIOBEHAV R, V73, P68, DOI 10.1016/j.neubiorev.2016.12.007
   Fornaro M, 2017, INT REV PSYCHIATR, V29, P425, DOI 10.1080/09540261.2017.1299695
   Foster C, 2017, Fronteras, V3, P187, DOI [10.21664/2238-8869.2017v6i3.p187-211, DOI 10.21664/2238-8869.2017V6I3.P187-211]
   Gordon JL, 2011, PSYCHOPHYSIOLOGY, V48, P1604, DOI 10.1111/j.1469-8986.2011.01232.x
   Gorenstein C, 1996, BRAZ J MED BIOL RES, V29, P453
   Hage B, 2017, FRONT PUBLIC HEALTH, V5, DOI 10.3389/fpubh.2017.00312
   Hage B, 2019, WORLD J BIOL PSYCHIA, V20, P359, DOI 10.1080/15622975.2017.1376113
   Hallgren M, 2017, EUR PSYCHIAT, V40, P1, DOI 10.1016/j.eurpsy.2016.08.011
   Hautala A, 2012, J SPORT SCI, V30, P563, DOI 10.1080/02640414.2012.658080
   Helgadóttir B, 2016, PREV MED, V91, P123, DOI 10.1016/j.ypmed.2016.08.011
   Helgadóttir B, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0115894
   Holtermann A, 2018, BRIT J SPORT MED, V52, P149, DOI 10.1136/bjsports-2017-097965
   Hughes JW, 2008, PSYCHOSOM MED, V70, P456, DOI 10.1097/PSY.0b013e31816fcab3
   Hughes JW, 2006, AM HEART J, V151, DOI 10.1016/j.ahj.2006.02.004
   Hwang J, 2017, PHYSIOL BEHAV, V179, P75, DOI 10.1016/j.physbeh.2017.05.011
   JACKSON AS, 1985, PHYSICIAN SPORTSMED, V13, P76, DOI 10.1080/00913847.1985.11708790
   Jandackova VK, 2016, PSYCHOL MED, V46, P2121, DOI 10.1017/S003329171600060X
   Kemp AH, 2014, AM J PSYCHIAT, V171, P1328, DOI 10.1176/appi.ajp.2014.13121605
   Kemp AH, 2014, FRONT PSYCHOL, V5, DOI 10.3389/fpsyg.2014.01387
   Kemp AH, 2010, BIOL PSYCHIAT, V67, P1067, DOI [10.1016/j.biopsych.2009.12.012, 10.1016/j.biopsych.2009.11.019]
   Kodama S, 2009, JAMA-J AM MED ASSOC, V301, P2024, DOI 10.1001/jama.2009.681
   Kraemer WJ, 2002, MED SCI SPORT EXER, V34, P364, DOI 10.1097/00005768-200202000-00027
   Lambert JD, 2018, J MED INTERNET RES, V20, DOI 10.2196/10112
   Lindwall M, 2007, J AGING PHYS ACTIV, V15, P41, DOI 10.1123/japa.15.1.41
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Madrazo Catinca, 2013, FP Essent, V411, P11
   Mannan M, 2016, ASIAN J PSYCHIATR, V21, P51, DOI 10.1016/j.ajp.2015.12.008
   Matsudo S., 2012, Rev Bras Ativ Fis Saude Internet, V6, P5, DOI DOI 10.12820/RBAFS.V.6N2P5-18
   Medeiros AR, 2017, INT J CARDIOL, V239, P23, DOI 10.1016/j.ijcard.2017.03.161
   Mehta LS, 2011, HEART FAIL CLIN, V7, P39, DOI 10.1016/j.hfc.2010.08.005
   Milaneschi Y, 2019, MOL PSYCHIATR, V24, P18, DOI 10.1038/s41380-018-0017-5
   Myers J, 2015, PROG CARDIOVASC DIS, V57, P306, DOI 10.1016/j.pcad.2014.09.011
   Papasavvas T, 2016, SPORTS MED, V46, P219, DOI 10.1007/s40279-015-0409-5
   Park G, 2014, FRONT PSYCHOL, V5, DOI 10.3389/fpsyg.2014.00278
   Peçanha T, 2017, INT J CARDIOL, V227, P795, DOI 10.1016/j.ijcard.2016.10.057
   Pedersen NH, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0186384
   Pereira-Miranda E, 2017, J AM COLL NUTR, V36, P223, DOI 10.1080/07315724.2016.1261053
   Schuch FB, 2015, J PSYCHIATR RES, V61, P25, DOI 10.1016/j.jpsychires.2014.11.005
   Schuch F, 2017, J AFFECT DISORDERS, V210, P139, DOI 10.1016/j.jad.2016.10.050
   Schuch FB, 2018, AM J PSYCHIAT, V175, P631, DOI 10.1176/appi.ajp.2018.17111194
   Schuch FB, 2016, PREV MED, V93, P159, DOI 10.1016/j.ypmed.2016.10.011
   Schuch FB, 2016, J PSYCHIATR RES, V77, P42, DOI 10.1016/j.jpsychires.2016.02.023
   Siri W E, 1993, Nutrition, V9, P480
   Sjöholm L, 2009, J AFFECT DISORDERS, V113, P66, DOI 10.1016/j.jad.2008.04.028
   Song MR, 2012, PUBLIC HEALTH NURS, V29, P208, DOI 10.1111/j.1525-1446.2011.00986.x
   Stapelberg NJ, 2012, AUST NZ J PSYCHIAT, V46, P946, DOI 10.1177/0004867412444624
   Stubbs B, 2016, J AFFECT DISORDERS, V190, P249, DOI 10.1016/j.jad.2015.10.010
   Stunkard AJ, 2003, BIOL PSYCHIAT, V54, P330, DOI 10.1016/S0006-3223(03)00608-5
   Sui XM, 2009, J PSYCHIATR RES, V43, P546, DOI 10.1016/j.jpsychires.2008.08.002
   Teychenne M, 2008, PREV MED, V46, P397, DOI 10.1016/j.ypmed.2008.01.009
   Thayer JF, 2010, INT J CARDIOL, V141, P122, DOI 10.1016/j.ijcard.2009.09.543
   Thayer JF, 2009, NEUROSCI BIOBEHAV R, V33, P81, DOI 10.1016/j.neubiorev.2008.08.004
   Trost SG, 2005, MED SCI SPORT EXER, V37, pS531, DOI 10.1249/01.mss.0000185657.86065.98
   Tudor-Locke C, 2011, INT J BEHAV NUTR PHY, V8, DOI 10.1186/1479-5868-8-79
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vancampfort D, 2017, WORLD PSYCHIATRY, V16, P308, DOI 10.1002/wps.20458
   Vancampfort D, 2017, SPORTS MED, V47, P343, DOI 10.1007/s40279-016-0574-1
   Vancampfort D, 2016, WORLD PSYCHIATRY, V15, P166, DOI 10.1002/wps.20309
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Wallén MB, 2012, EUR J APPL PHYSIOL, V112, P1153, DOI 10.1007/s00421-011-2079-9
   WHO, 2017, GLOB HLTH EST DEPR O
   Wise LA, 2006, ANN BEHAV MED, V32, P68, DOI 10.1207/s15324796abm3201_8
   World Health Organization, 2017, DEPR LETS TALK SAYS
   Zembron-Lacny A, 2016, BRAZ J MED BIOL RES, V49, DOI [10.1590/1414-431X20165253, 10.1590/1414-431x20165253]
   Zhang JC, 2016, CURR NEUROPHARMACOL, V14, P721, DOI 10.2174/1570159X14666160119094646
NR 95
TC 16
Z9 16
U1 0
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD APR 12
PY 2019
VL 10
AR 192
DI 10.3389/fpsyt.2019.00192
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HT2QN
UT WOS:000464407600002
PM 31031652
OA Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Iguacel, I
   Börnhorst, C
   Michels, N
   Breidenassel, C
   Dallongeville, J
   González-Gross, M
   Gottrand, F
   Kafatos, A
   Karaglani, E
   Kersting, M
   de Henauw, S
   Lambrinou, CP
   Mistura, L
   Molnár, D
   Nova, E
   Gunter, MJ
   Puerta, AD
   Rupérez, AI
   Widhalm, K
   Huybrechts, I
   Moreno, LA
AF Iguacel, Isabel
   Boernhorst, Claudia
   Michels, Nathalie
   Breidenassel, Christina
   Dallongeville, Jean
   Gonzalez-Gross, Marcela
   Gottrand, Frederic
   Kafatos, Anthony
   Karaglani, Eva
   Kersting, Mathilde
   Henauw, Stefaan de
   Lambrinou, Christina-Paulina
   Mistura, Lorenza
   Molnar, Denes
   Nova, Esther
   Gunter, Marc J.
   Puerta, Alejandro de la O.
   Ruperez, Azahara I.
   Widhalm, Kurt
   Huybrechts, Inge
   Moreno, Luis A.
TI Socioeconomically Disadvantaged Groups and Metabolic Syndrome in
   European Adolescents: The HELENA Study
SO JOURNAL OF ADOLESCENT HEALTH
LA English
DT Article
DE Metabolic syndrome; Socioeconomic disadvantages; Socioeconomic status;
   Obesity; adolescents; Modifiable lifestyle indicators
ID CHILDHOOD; DIETARY; HEALTH; LIFE; CHILDREN; OBESITY; DEFINITIONS;
   MULTICENTER; PREVALENCE; VALIDATION
AB Purpose: Psychosocial stressors derived from socioeconomic disadvantages in adolescents can result in higher risk of metabolic syndrome (MetS). We aimed to examine whether socioeconomic disadvantages were associated with MetS independent of lifestyle and whether there was a dose response relationship between the number of cumulated socioeconomic disadvantages and risk of MetS.
   Methods: This study included 1,037 European adolescents (aged 12.5-17.5 years). Sociodemographic variables and lifestyle were assessed by self-reported questionnaires. Disadvantaged groups included adolescents with low-educated parents, low family affluence, migrant origin, unemployed parents, and nontraditional families. MetS risk score was calculated as the sum of sex and age-specific z-scores of waist circumference, blood pressure, lipids, and insulin resistance. Linear mixed-effects models adjusted for sex, age, pubertal status, and lifestyle were used to study the association between social disadvantages and MetS risk score.
   Results: Adolescents with low-educated mothers showed a higher MetS score (.54 [.09-.98]; b estimate and 99% confidence interval) compared to those with high-educated mothers. Adolescents who accumulated more than three disadvantages (.69 [.08-1.31]) or with missing information on disadvantages (.72 [.04-1.40]) had a higher MetS risk score compared to nonsocioeconomically disadvantaged groups. Stronger associations between socioeconomic disadvantages and MetS were found in male than in female adolescents.
   Conclusions: Adolescents with low-educated mothers or with more than three socioeconomic disadvantages had a higher MetS risk, independent of lifestyle, potentially due to higher psychosocial stress exposure. Policy makers should focus on improving low-educated familiesa and more disadvantaged families' knowledge on nutrition and physical activity to help them cope better with stress. (C) 2020 Society for Adolescent Health and Medicine. All rights reserved.
C1 [Iguacel, Isabel; Ruperez, Azahara I.; Moreno, Luis A.] Univ Zaragoza, GENUD Growth Exercise Nutr & Dev Res Grp, Fac Hlth Sci, Deparment Physiatry & Nursing, Zaragoza, Spain.
   [Iguacel, Isabel; Ruperez, Azahara I.; Moreno, Luis A.] Inst Agroalimentario Aragon IA2, Zaragoza, Spain.
   [Iguacel, Isabel; Ruperez, Azahara I.; Moreno, Luis A.] Inst Invest Sanitaria Aragon IIS Aragon, Zaragoza, Spain.
   [Iguacel, Isabel; Ruperez, Azahara I.; Moreno, Luis A.] Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain.
   [Boernhorst, Claudia] Leibniz Inst Prevent Res & Epidemiol BIPS, Dept Biometry & Data Management, Bremen, Germany.
   [Michels, Nathalie; Henauw, Stefaan de; Huybrechts, Inge] Univ Ghent, Dept Publ Hlth, Ghent, Belgium.
   [Breidenassel, Christina; Kersting, Mathilde] Rhein Friedrich Wilhelms Univ Bonn, Dept Nutr Humannutr, Bonn, Germany.
   [Breidenassel, Christina; Gonzalez-Gross, Marcela] Univ Politecn Madrid, Fac Ciencias Act Fis & Deporte INEF, Dept Hlth & Human Performance, ImFine Res Grp, Madrid, Spain.
   [Dallongeville, Jean] Inst Pasteur, Dept Epidemiol & Publ Hlth, Lille, France.
   [Gonzalez-Gross, Marcela] Univ Politecn Madrid, Fac Ciencias Act Fsica & Deporte INEF, Dept Hlth & Human Performance, Madrid, Spain.
   [Gottrand, Frederic] Univ Lille2, INSERM, Fac Med, U995,IFR114, F-IFR114 Lille, France.
   [Kafatos, Anthony; Lambrinou, Christina-Paulina] Univ Crete, Prevent Med & Nutr Clin, Iraklion, Greece.
   [Karaglani, Eva] Harokopio Univ Athens, Depnt Nutr & Dietet, Athens, Greece.
   [Mistura, Lorenza] Council Agr Res & Econ, Res Ctr Food & Nutr, Rome, Italy.
   [Molnar, Denes] Univ Pecs, Dept Paediat, Pecs, Hungary.
   [Nova, Esther] Spanish Natl Res Council ICTAN CSIC, Immunonutr Grp Metab & Nutr Dept, EInstitute Food Sci Technol & Nutr, Madrid, Spain.
   [Gunter, Marc J.; Huybrechts, Inge] World Hlth Org, Int Agcy Res Canc, Lyon, France.
   [Puerta, Alejandro de la O.] Univ Granada, Dept Physiol, Fac Med, Granada, Spain.
   [Widhalm, Kurt] Univ Vienna, Dept Pediat, Vienna, Austria.
C3 University of Zaragoza; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN; Leibniz Association; Leibniz Institute for Prevention
   Research & Epidemiology (BIPS); Ghent University; University of Bonn;
   Universidad Politecnica de Madrid; Facultad de Ciencias de la Actividad
   Fisica del Deporte (INEF); Pasteur Network; Universite de Lille;
   Institut Pasteur Lille; Universidad Politecnica de Madrid; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite de
   Lille; University of Crete; Harokopio University Athens; Consiglio per
   la Ricerca in Agricoltura e L'analisi Dell'economia Agraria (CREA);
   University of Pecs; Consejo Superior de Investigaciones Cientificas
   (CSIC); CSIC - Instituto de Ciencia y Tecnologia de Alimentos y
   Nutricion (ICTAN); World Health Organization; International Agency for
   Research on Cancer (IARC); University of Granada; University of Vienna
RP Iguacel, I (corresponding author), Univ Zaragoza, Zaragoza, Spain.
EM iguacel@unizar.es
RI Kengne, Andre/ABB-3696-2020; Crujeiras, Ana B/ABA-8866-2021; Gianfagna,
   Francesco/K-4561-2016; Moreno, Luis/S-1780-2019; Gunter,
   Marc/AAP-8621-2020; Molnár, Dénes/AAB-6820-2022; Iguacel Azorín,
   Isabel/ABC-7789-2021; Huybrechts, Inge/ITT-7052-2023; Michels,
   Nathalie/C-2819-2012; gottrand, frederic/G-7370-2015
OI Moreno Aznar, Luis A./0000-0003-0454-653X; Iguacel,
   Isabel/0000-0003-4242-5464; Gonzalez-Gross, Marcela/0000-0001-7757-3235;
   gottrand, frederic/0000-0002-5290-0436; Michels,
   Nathalie/0000-0002-3069-7254; De-la-O, Alejandro/0000-0002-0614-4545;
   Karaglani, Eva/0000-0001-5395-7023
FU European Community sixth RTD Framework Programme [FOOD-CT-2005-007034]
FX The HELENA Study was conducted with the financial support of the
   European Community sixth RTD Framework Programme (Contract
   FOOD-CT-2005-007034).
CR Ahrens W, 2014, INT J OBESITY, V38, pS4, DOI 10.1038/ijo.2014.130
   Anagnostis P, 2009, J CLIN ENDOCR METAB, V94, P2692, DOI 10.1210/jc.2009-0370
   Bammann K, 2013, PEDIATR OBES, V8, P1, DOI 10.1111/j.2047-6310.2012.00075.x
   Béghin L, 2012, ARCH PUBLIC HEALTH, V70, DOI 10.1186/0778-7367-70-14
   Boyce W, 2006, SOC INDIC RES, V78, P473, DOI 10.1007/s11205-005-1607-6
   Candib LM, 2007, ANN FAM MED, V5, P547, DOI 10.1370/afm.754
   Darmon N, 2001, PUBLIC HEALTH NUTR, V4, P163, DOI 10.1079/PHN200064
   Elsenburg LK, 2017, OBESITY, V25, P820, DOI 10.1002/oby.21797
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   Freedman LS, 2011, J NATL CANCER I, V103, P1086, DOI 10.1093/jnci/djr189
   González-Gross M, 2008, INT J OBESITY, V32, pS66, DOI 10.1038/ijo.2008.185
   Grimes DA, 2002, LANCET, V359, P145, DOI 10.1016/S0140-6736(02)07373-7
   IBM Corp, IBM SPSS Statistics for Windows
   Iguacel I, 2018, INT J OBESITY, V42, P1691, DOI 10.1038/s41366-018-0199-6
   Iguacel I, 2018, INT J CARDIOL, V272, P333, DOI 10.1016/j.ijcard.2018.07.053
   Iguacel I, 2017, EUR CHILD ADOLES PSY, V26, P1105, DOI 10.1007/s00787-017-0998-7
   Iguacel I, 2016, BRIT J NUTR, V116, P1288, DOI 10.1017/S0007114516003330
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kim S, 2007, PUBLIC HEALTH REP, V122, P753, DOI 10.1177/003335490712200607
   Little P, 1999, J EPIDEMIOL COMMUN H, V53, P165, DOI 10.1136/jech.53.3.165
   Liu JH, 2009, ETHNIC HEALTH, V14, P509, DOI 10.1080/13557850902890209
   Loucks EB, 2007, ANN EPIDEMIOL, V17, P782, DOI 10.1016/j.annepidem.2007.05.003
   Loucks EB, 2007, ANN EPIDEMIOL, V17, P19, DOI 10.1016/j.annepidem.2006.07.002
   Lovasi GS, 2009, EPIDEMIOL REV, V31, P7, DOI 10.1093/epirev/mxp005
   Michels N, 2015, HEALTH PSYCHOL, V34, P40, DOI 10.1037/hea0000108
   Miller JM, 2014, METAB SYNDR RELAT D, V12, P527, DOI 10.1089/met.2014.0055
   Nagy E, 2008, INT J OBESITY, V32, pS58, DOI 10.1038/ijo.2008.184
   Nolan Paul B, 2017, Prev Med Rep, V7, P211, DOI 10.1016/j.pmedr.2017.07.004
   Olsson CA, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2015-010455
   Park HS, 2004, INT J EPIDEMIOL, V33, P328, DOI 10.1093/ije/dyh032
   Poulton R, 2005, INT J EPIDEMIOL, V34, P344, DOI 10.1093/ije/dyi044
   Puolakka E, 2016, DIABETES CARE, V39, P2311, DOI 10.2337/dc16-1565
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Stronks K, 2009, ETHNIC HEALTH, V14, P255, DOI 10.1080/13557850802509206
   Suglia SF, 2018, CIRCULATION, V137, pE15, DOI 10.1161/CIR.0000000000000536
   Tamashiro KLK, 2011, ANN NY ACAD SCI, V1231, P46, DOI 10.1111/j.1749-6632.2011.06134.x
   TANNER JM, 1976, ARCH DIS CHILD, V51, P170, DOI 10.1136/adc.51.3.170
   Vanlancker T, 2017, EUR J PEDIATR, V176, P241, DOI 10.1007/s00431-016-2831-6
   Vyncke K, 2013, BRIT J NUTR, V109, P2067, DOI 10.1017/S000711451200414X
   Wu HF, 2017, ANN EPIDEMIOL, V27, P315, DOI 10.1016/j.annepidem.2017.04.003
   Xu YQ, 2008, ACTA PAEDIATR, V97, P348, DOI 10.1111/j.1651-2227.2008.00665.x
NR 41
TC 12
Z9 13
U1 1
U2 13
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1054-139X
EI 1879-1972
J9 J ADOLESCENT HEALTH
JI J. Adolesc. Health
PD JAN
PY 2021
VL 68
IS 1
BP 146
EP 154
DI 10.1016/j.jadohealth.2020.05.027
PG 9
WC Psychology, Developmental; Public, Environmental & Occupational Health;
   Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Public, Environmental & Occupational Health; Pediatrics
GA PZ2DI
UT WOS:000612549900024
PM 32636143
OA Green Published, Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Marycz, K
   Szlapka-Kosarzewska, J
   Geburek, F
   Kornicka-Garbowska, K
AF Marycz, Krzysztof
   Szlapka-Kosarzewska, J.
   Geburek, F.
   Kornicka-Garbowska, K.
TI Systemic Administration of Rejuvenated Adipose-Derived Mesenchymal Stem
   Cells Improves Liver Metabolism in Equine Metabolic Syndrome (EMS)- New
   Approach in Veterinary Regenerative Medicine
SO STEM CELL REVIEWS AND REPORTS
LA English
DT Article
DE Equine metabolic syndrome; Adipose derived stem cells; Liver; Cell
   therapy; Mesenchymal stem cells
ID OXIDATIVE STRESS; PHARMACOKINETICS; DIFFERENTIATION; RESVERATROL;
   PREVALENCE; MECHANISMS; AUTOPHAGY; OBESITY; HORSES; MICE
AB Equine metabolic syndrome (EMS) is characterized by adiposity, insulin dysregulation and increased risk for laminitis. Increased levels of specific liver enzymes in the peripheral blood are typical findings in horses diagnosed with EMS. Current management of EMS is based on caloric restriction and increased physical activity. However, new potential treatment options are arising such as the transplantation of autologous adipose stem cells (ASC). However, cytophysiological properties of ASC derived from EMS horses are impaired which strongly limits their therapeutic potential. We hypothesized, that in vitro pharmacotherapy of those cells with 5-azacytidine (AZA) and resveratrol (RES) before their clinical application can reverse the aged phenotype of those cells and improve clinical outcome of autologous therapy. A 9 year old Dutch Warmblood Horse used for driving, was presented with severe obesity, insulin resistance. After EMS diagnosis, the animal received three intravenous injections of autologous, AZA/RES treated ASCs at weekly intervals. The therapeutic effect was assessed by the analysis of liver specific enzymes in the blood. ASC-transplantation reduced levels of glutamate dehydrogenase (GLDH), gamma-glutamyltransferase (GGT), lactate dehydrogenase (LDH) and aspartate transaminase (AST). This case report demonstrates the therapeutic potential of this intervention for EMS as well as apt utility of autologous, rejuvenated ASC injections.
C1 [Marycz, Krzysztof; Kornicka-Garbowska, K.] Int Inst Translat Med, Jesionowa 11 St, PL-55114 Wisznia Mala, Poland.
   [Marycz, Krzysztof; Kornicka-Garbowska, K.] Univ Environm & Life Sci Wroclaw, Fac Biol & Anim Sci, Dept Expt Biol, Wroclaw, Poland.
   [Marycz, Krzysztof; Geburek, F.] Justus Liebig Univ, Dept Surg, Clin Horses, Fac Vet Med, Giessen, Germany.
C3 Wroclaw University of Environmental & Life Sciences; Justus Liebig
   University Giessen
RP Marycz, K (corresponding author), Int Inst Translat Med, Jesionowa 11 St, PL-55114 Wisznia Mala, Poland.; Marycz, K (corresponding author), Univ Environm & Life Sci Wroclaw, Fac Biol & Anim Sci, Dept Expt Biol, Wroclaw, Poland.; Marycz, K (corresponding author), Justus Liebig Univ, Dept Surg, Clin Horses, Fac Vet Med, Giessen, Germany.
EM krzysztof.marycz@upwr.edu.pl
FU National Science Centre in Poland [2016/21/B/NZ7/01111,
   2018/29/B/NZ7/02662]
FX This project was financed within the framework of a grants entitled
   "Modulation mitochondrial metabolism and dynamics and targeting DNA
   methylation of adipose derived mesenchymal stromal stem cell (ASC) using
   resveratrol and 5-azacytydin as a therapeutic strategy in the course of
   Equine metabolic syndrome (EMS)." (grant no. 2016/21/B/NZ7/01111) and
   "Inhibition of tyrosine phosphatase as a strategy to enhance insulin
   sensitivity through activation of chaperone mediated autophagy and
   amelioration of inflammation and cellular stress in the liver of
   equinemetabolic syndrome (EMS) horses." (grant no. 2018/29/B/NZ7/02662)
   financed by The National Science Centre in Poland.
CR Abumaree M, 2012, STEM CELL REV REP, V8, P375, DOI 10.1007/s12015-011-9312-0
   Aguirre L, 2014, MOLECULES, V19, P18632, DOI 10.3390/molecules191118632
   Bhullar KS, 2015, BBA-MOL BASIS DIS, V1852, P1209, DOI 10.1016/j.bbadis.2015.01.012
   Bourebaba L, 2019, STEM CELL REV REP, V15, P374, DOI 10.1007/s12015-019-09875-6
   Carter RA, 2009, VET J, V179, P204, DOI 10.1016/j.tvjl.2008.02.029
   Cislo-Pakuluk A, 2017, STEM CELL REV REP, V13, P598, DOI 10.1007/s12015-017-9750-4
   DAJUSTAPINHEIRO CH, 2012, STEM CELL REV, V8, P363, DOI DOI 10.1007/s12015-011-9304-0
   Eggenhofer E, 2012, FRONT IMMUNOL, V3, DOI 10.3389/fimmu.2012.00297
   Fiore EJ, 2015, STEM CELL REV REP, V11, P586, DOI 10.1007/s12015-015-9585-9
   Frank N, 2017, J VET INTERN MED, V31, P1178, DOI 10.1111/jvim.14725
   Frank N, 2009, J EQUINE VET SCI, V29, P259, DOI 10.1016/j.jevs.2009.04.183
   Gülçin I, 2010, INNOV FOOD SCI EMERG, V11, P210, DOI 10.1016/j.ifset.2009.07.002
   Holan V, 2016, STEM CELL REV REP, V12, P654, DOI 10.1007/s12015-016-9688-y
   Huang B, 2016, J TRANSL MED, V14, DOI 10.1186/s12967-016-0792-1
   Hustace JL, 2009, AM J VET RES, V70, P665, DOI 10.2460/ajvr.70.5.665
   Kim G, 2015, J KOREAN MED SCI, V30, P1405, DOI 10.3346/jkms.2015.30.10.1405
   Kornicka K, 2019, J CELL MOL MED, V23, P237, DOI 10.1111/jcmm.13914
   Kornicka K, 2018, J CLIN MED, V7, DOI 10.3390/jcm7110383
   Kornicka K, 2018, STEM CELL REV REP, V14, P337, DOI 10.1007/s12015-018-9809-x
   Kornicka K, 2017, J CELL MOL MED, V21, P387, DOI 10.1111/jcmm.12972
   Kosolofski HR, 2017, CAN VET J, V58, P967
   Lee RH, 2009, CELL STEM CELL, V5, P54, DOI 10.1016/j.stem.2009.05.003
   Lindroos B, 2011, STEM CELL REV REP, V7, P269, DOI 10.1007/s12015-010-9193-7
   Liu ZC, 2014, CYTOTHERAPY, V16, P1207, DOI 10.1016/j.jcyt.2014.05.018
   Madrigal M, 2014, J TRANSL MED, V12, DOI 10.1186/s12967-014-0260-8
   Maredziak M, 2015, IN VITRO CELL DEV-AN, V51, P230, DOI 10.1007/s11626-014-9828-0
   Marycz K, 2012, VET MED-CZECH, V57, P610, DOI 10.17221/6469-VETMED
   Marycz K, 2018, J CELL MOL MED, V22, P4771, DOI 10.1111/jcmm.13731
   Marycz K, 2018, RES VET SCI, V118, P115, DOI 10.1016/j.rvsc.2018.01.015
   Marycz K, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/4710326
   Marycz K, 2016, J CELL MOL MED, V20, P2384, DOI 10.1111/jcmm.12932
   Marycz K, 2016, STEM CELLS INT, V2016, DOI 10.1155/2016/5756901
   Melief SM, 2013, STEM CELLS, V31, P1980, DOI 10.1002/stem.1432
   Nam A, 2017, J VET INTERN MED, V31, P1514, DOI 10.1111/jvim.14798
   Oreffo ROC, 2005, STEM CELL REV, V1, P169, DOI 10.1385/SCR:1:2:169
   Owens SD, 2016, STEM CELLS INT, V2016, DOI 10.1155/2016/5830103
   Pezzanite LM, 2015, STEM CELL RES THER, V6, DOI 10.1186/s13287-015-0053-x
   Piryaei A, 2011, STEM CELL REV REP, V7, P103, DOI 10.1007/s12015-010-9126-5
   Powell DM, 2002, EQUINE VET J, V34, P81
   Shree N, 2017, J CELL BIOCHEM, V118, P2037, DOI 10.1002/jcb.25777
   Si YL, 2012, DIABETES, V61, P1616, DOI 10.2337/db11-1141
   Stephenson HM, 2011, VET REC, V168, P131, DOI 10.1136/vr.c6281
   Svajger U, 2012, INT REV IMMUNOL, V31, P202, DOI 10.3109/08830185.2012.665108
   Tsuchiya A, 2017, INFLAMM REGEN, V37, DOI 10.1186/s41232-017-0045-6
   Wang HF, 2018, MOL MED REP, V17, P3769, DOI 10.3892/mmr.2017.8326
   Wang LF, 2013, J GASTROEN HEPATOL, V28, P85, DOI 10.1111/jgh.12029
   Wearn JMG, 2011, J VET PHARMACOL THER, V34, P252, DOI 10.1111/j.1365-2885.2010.01217.x
   Wyse CA, 2008, VET REC, V162, P590, DOI 10.1136/vr.162.18.590
   Xie ZY, 2016, STEM CELLS, V34, P627, DOI 10.1002/stem.2238
   Yan XY, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0090846
   Zheng S, 2015, INT J CLIN EXP PATHO, V8, P15854
NR 51
TC 17
Z9 18
U1 0
U2 19
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2629-3269
EI 2629-3277
J9 STEM CELL REV REP
JI Stem Cell Rev. Rep.
PD DEC
PY 2019
VL 15
IS 6
BP 842
EP 850
DI 10.1007/s12015-019-09913-3
EA OCT 2019
PG 9
WC Cell & Tissue Engineering; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA KI9VU
UT WOS:000490884300001
PM 31620992
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Hua, HY
   Yang, JL
   Lin, HT
   Xi, Y
   Dai, MY
   Xu, GM
   Wang, FY
   Liu, LH
   Zhao, TQ
   Huang, J
   Gonzalez, FJ
   Liu, AM
AF Hua, Huiying
   Yang, Julin
   Lin, Hante
   Xi, Yang
   Dai, Manyun
   Xu, Gangming
   Wang, Fuyan
   Liu, Lihong
   Zhao, Tingqi
   Huang, Jing
   Gonzalez, Frank J.
   Liu, Aiming
TI PPARα-independent action against metabolic syndrome development by
   fibrates is mediated by inhibition of STAT3 signalling
SO JOURNAL OF PHARMACY AND PHARMACOLOGY
LA English
DT Article
DE fenofibrate; gemfibrozil; metabolic syndrome; PPAR alpha; STAT3
ID ACTIVATED-RECEPTOR-ALPHA; IMPROVES INSULIN SENSITIVITY; NF-KAPPA-B;
   INTRAHEPATIC CHOLESTASIS; OXIDATIVE STRESS; BODY-WEIGHT; US ADULTS;
   INFLAMMATION; FENOFIBRATE; DISRUPTION
AB Objectives Metabolic syndrome (MS) is the concurrence of at least three of five medical conditions: obesity, high blood pressure, insulin resistance, high serum triglyceride (TG) and low serum high-density lipoprotein levels. While fibrates are used to treat disorders other than the lowering serum TG, the mechanism by which fibrates decrease MS has not been established. Methods Key findings In this study, wild-type and Ppara-null mice fed a medium-fat diet (MFD) were administered gemfibrozil and fenofibrate for 3 months respectively, to explore the effect and action mechanism. In Ppara-null mice, MFD treatment increased body weight, adipose tissue, serum TG and impaired glucose tolerance. These phenotypes were attenuated in two groups treated with gemfibrozil and fenofibrate. The STAT3 pathway was activated in adipose and hepatic tissues in positive control, and inhibited in groups treated with gemfibrozil and fenofibrate. The above phenotypes and inflammation were not observed in any wild-type group. In 3T3-L1 adipogenic stem cells treated with high glucose, STAT3 knockdown greatly decreased the number of lipid droplets. Conclusions Low dose of clinical fibrates was effective against MS development independent of PPAR alpha, and this action was mediated by STAT3 signalling inhibition in adipose tissue and, to a lesser extent, in hepatic tissues.
C1 [Hua, Huiying; Lin, Hante; Xi, Yang; Dai, Manyun; Xu, Gangming; Wang, Fuyan; Liu, Lihong; Zhao, Tingqi; Huang, Jing; Liu, Aiming] Ningbo Univ, Med Sch, Ningbo 315211, Zhejiang, Peoples R China.
   [Yang, Julin] Ningbo Coll Hlth Sci, Ningbo, Zhejiang, Peoples R China.
   [Gonzalez, Frank J.] NCI, Lab Metab, NIH, Bethesda, MD 20892 USA.
C3 Ningbo University; National Institutes of Health (NIH) - USA; NIH
   National Cancer Institute (NCI)
RP Liu, AM (corresponding author), Ningbo Univ, Med Sch, Ningbo 315211, Zhejiang, Peoples R China.
EM liuaiming@nbu.edu.cn
RI Dai, Manyun/GZB-0789-2022; Gonzalez, Francisco/GWV-3999-2022; Zhou,
   Yonggang/HJJ-8642-2023
OI Gonzalez, Frank/0000-0002-7990-2140
FU Ningbo Natural Science Foundation [2018A610253, 2018A610384]; K.C. Wong
   Magna Fund in Ningbo University; National Cancer Institute Intramural
   Research Program
FX This work was supported by the Ningbo Natural Science Foundation (Grant
   Nos. 2018A610253, 2018A610384); the K.C. Wong Magna Fund in Ningbo
   University; and the National Cancer Institute Intramural Research
   Program.
CR Calkin AC, 2006, DIABETOLOGIA, V49, P766, DOI 10.1007/s00125-005-0102-6
   Catrysse L, 2017, TRENDS CELL BIOL, V27, P417, DOI 10.1016/j.tcb.2017.01.006
   Cernkovich ER, 2008, ENDOCRINOLOGY, V149, P1581, DOI 10.1210/en.2007-1148
   Chen HL, 2016, NUTR DIABETES, V6, DOI 10.1038/nutd.2016.49
   Chen H, 2016, J ETHNOPHARMACOL, V179, P197, DOI 10.1016/j.jep.2015.12.033
   Dai MY, 2018, J PROTEOME RES, V17, P1500, DOI 10.1021/acs.jproteome.7b00838
   Dai MY, 2017, BRIT J PHARMACOL, V174, P3000, DOI 10.1111/bph.13928
   Dana SL, 2001, METABOLISM, V50, P963, DOI 10.1053/meta.2001.24870
   DeFronzo RA, 2011, NEW ENGL J MED, V364, P1104, DOI 10.1056/NEJMoa1010949
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Gan L, 2018, INT J OBESITY, V42, P252, DOI 10.1038/ijo.2017.208
   Gandhi N, 2014, SPRINGERPLUS, V3, DOI 10.1186/2193-1801-3-14
   Gao Q, 2004, P NATL ACAD SCI USA, V101, P4661, DOI 10.1073/pnas.0303992101
   Guerre-Millo M, 2001, DIABETES, V50, P2809, DOI 10.2337/diabetes.50.12.2809
   Guerre-Millo M, 2000, J BIOL CHEM, V275, P16638, DOI 10.1074/jbc.275.22.16638
   Han MS, 2013, SCIENCE, V339, P218, DOI 10.1126/science.1227568
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Howard Barbara V, 2002, Circulation, V105, pe132, DOI 10.1161/01.CIR.0000013953.41667.09
   Inoue H, 2004, NAT MED, V10, P168, DOI 10.1038/nm980
   Investigators DO, 2010, DIABETOLOGIA, V54, P487
   Jiang CT, 2011, DIABETES, V60, P2484, DOI 10.2337/db11-0174
   Li F, 2017, PHARMACOL THERAPEUT, V178, P18, DOI 10.1016/j.pharmthera.2017.03.007
   Li F, 2012, J LIPID RES, V53, P1625, DOI 10.1194/jlr.M027433
   Lim S, 2014, REV ENDOCR METAB DIS, V15, P329, DOI 10.1007/s11154-014-9298-4
   Liu AM, 2014, CHEM-BIOL INTERACT, V223, P80, DOI 10.1016/j.cbi.2014.09.012
   Liu AM, 2012, VASC PHARMACOL, V56, P168, DOI 10.1016/j.vph.2012.01.003
   Liu SN, 2011, J TRANSL MED, V9, DOI 10.1186/1479-5876-9-176
   MacDonald MLE, 2009, ARTERIOSCL THROM VAS, V29, P341, DOI 10.1161/ATVBAHA.108.181099
   Mozumdar A, 2011, DIABETES CARE, V34, P216, DOI 10.2337/dc10-0879
   Neschen S, 2007, DIABETES, V56, P1034, DOI 10.2337/db06-1206
   Ning LJ, 2017, SCI REP-UK, V7, DOI 10.1038/srep41706
   Noguchi T, 2011, ATHEROSCLEROSIS, V217, P165, DOI 10.1016/j.atherosclerosis.2011.02.012
   Peng Y, 2012, PPAR RES, V2012, DOI 10.1155/2012/970525
   Phelps Laura E., 2010, Journal of Smooth Muscle Research, V46, P125
   Shi SY, 2012, J BIOL CHEM, V287, P10277, DOI 10.1074/jbc.M111.317453
   Silswal N, 2012, PPAR RES, V2012, DOI 10.1155/2012/302495
   Skop V, 2016, PHYSIOL RES, V65, P891, DOI 10.33549/physiolres.933304
   Socha Piotr, 2007, Rocz Panstw Zakl Hig, V58, P129
   Song DJ, 2016, PHARMAZIE, V71, P205, DOI 10.1691/ph.2016.5776
   Sos BC, 2011, J CLIN INVEST, V121, P1412, DOI 10.1172/JCI42894
   Tan Z, 2016, AM J CHINESE MED, V44, P721, DOI 10.1142/S0192415X16500397
   Tordjman K, 2001, J CLIN INVEST, V107, P1025, DOI 10.1172/JCI11497
   Ueno H, 2011, OBES RES CLIN PRACT, V5, pE335, DOI 10.1016/j.orcp.2011.03.012
   Yang YB, 2014, OBESITY, V22, P2147, DOI 10.1002/oby.20811
   Yuan YY, 2017, BIOCHEM BIOPH RES CO, V482, P1360, DOI 10.1016/j.bbrc.2016.12.042
   Zeng ZH, 2017, EXP CLIN ENDOCR DIAB, V125, P610, DOI 10.1055/s-0043-101919
   Zhang P, 2015, GYNECOL ONCOL, V139, P529, DOI 10.1016/j.ygyno.2015.09.087
   Zhao XY, 2008, AM J NEPHROL, V28, P598, DOI 10.1159/000116885
NR 48
TC 10
Z9 12
U1 1
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3573
EI 2042-7158
J9 J PHARM PHARMACOL
JI J. Pharm. Pharmacol.
PD DEC
PY 2018
VL 70
IS 12
BP 1630
EP 1642
DI 10.1111/jphp.13014
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GZ7TT
UT WOS:000449687300005
PM 30251457
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ben Amara, N
   Tourniaire, F
   Maraninchi, M
   Attia, N
   Amiot-Carlin, MJ
   Raccah, D
   Valéro, R
   Landrier, JF
   Darmon, P
AF Ben Amara, N.
   Tourniaire, F.
   Maraninchi, M.
   Attia, N.
   Amiot-Carlin, M. J.
   Raccah, D.
   Valero, R.
   Landrier, J. F.
   Darmon, P.
TI Independent positive association of plasma β-carotene concentrations
   with adiponectin among non-diabetic obese subjects
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Carotenoids; Adiponectin; beta-Carotene; Lycopene; HOMA-IR
ID ARTERY RISK DEVELOPMENT; 3RD NATIONAL-HEALTH; METABOLIC SYNDROME; SERUM
   CAROTENOIDS; DIABETES-MELLITUS; ANTIOXIDANT CONCENTRATIONS;
   CARDIOVASCULAR-DISEASE; GLUCOSE-METABOLISM; OXIDATIVE STRESS; VITAMIN-E
AB Many epidemiological studies find an inverse correlation between carotenoids intake or carotenoids plasma concentrations and body mass index (BMI), insulin resistance or metabolic syndrome in the general population. However, it is not clear whether these relationships occur in obese population.
   We conducted a cross-sectional study in 108 obese non-diabetic patients.
   There was an inverse correlation between plasma levels of pro-vitamin A carotenoids (alpha-carotene, beta-carotene and beta-cryptoxanthin) and both BMI and insulin resistance (estimated by the HOMA-IR). No correlation between plasma concentrations of lycopene or lutein/zeaxanthin and BMI or insulin resistance was found. The inverse association between the three pro-vitamin A carotenoids and HOMA-IR disappeared after adjustment for BMI and waist circumference. Interestingly, we identified a positive association between concentrations of beta-carotene and adiponectin in plasma that was independent of sex, age, smoking status, BMI and waist circumference. To our knowledge, such association has never been described in obese patients.
   These results suggest the existence of a favourable effect of beta-carotene on insulin sensitivity in obese individuals that could involve a positive regulation of adiponectin, either directly or via its pro-vitamin A activity. The demonstration of the potential benefits of beta-carotene towards insulin sensitivity would open the way to dietary strategies to prevent metabolic syndrome.
C1 [Ben Amara, N.; Tourniaire, F.; Maraninchi, M.; Amiot-Carlin, M. J.; Raccah, D.; Valero, R.; Landrier, J. F.; Darmon, P.] Univ Aix Marseille, INRA, UMR 1260, F-13385 Marseille 05, France.
   [Ben Amara, N.; Tourniaire, F.; Maraninchi, M.; Amiot-Carlin, M. J.; Raccah, D.; Valero, R.; Landrier, J. F.; Darmon, P.] INSERM, UMR 1062, Nutr Obesite & Risque Thrombot, F-13385 Marseille 05, France.
   [Ben Amara, N.; Tourniaire, F.; Maraninchi, M.; Amiot-Carlin, M. J.; Raccah, D.; Valero, R.; Landrier, J. F.; Darmon, P.] Aix Marseille Univ, Fac Med, F-13385 Marseille 05, France.
   [Attia, N.] Fac Sci Bizerte, Lab Physiol Integree, Jarzouna 7021, Tunisia.
C3 INRAE; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Aix-Marseille Universite; Institut National de la Sante et de
   la Recherche Medicale (Inserm); Aix-Marseille Universite; Universite de
   Carthage
RP Darmon, P (corresponding author), Univ Aix Marseille, INRA, UMR 1260, 27 Bd Jean Moulin, F-13385 Marseille 05, France.
EM jean-francois.landrier@univ-amu.fr; Patrice.DARMON@ap-hm.fr
RI AMIOT, MARIE/N-8894-2019; Maraninchi, Marie/M-5813-2016; Tourniaire,
   Franck/K-9131-2017; Landrier, Jean-Francois/AAH-2757-2019; AMIOT, Marie
   Josephe/M-1203-2017
OI Darmon, Patrice/0000-0003-1726-2296; Maraninchi,
   Marie/0000-0002-6645-1811; Tourniaire, Franck/0000-0002-6394-7045;
   Landrier, Jean-Francois/0000-0002-8690-8014; VALERO,
   RENE/0000-0002-2176-3280; AMIOT, Marie Josephe/0000-0003-4563-4587
FU INRA; Aix-Marseille University; AP-HM
FX The authors thank Catherine Clement, dietitian, for her expertise in
   managing and analysing the nutrition-related data. This study was
   supported by INRA, Aix-Marseille University and AP-HM.
CR Al-Delaimy WK, 2005, EUR J CLIN NUTR, V59, P1387, DOI 10.1038/sj.ejcn.1602252
   Amengual J, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020644
   Andersen LF, 2006, BRIT J NUTR, V95, P358, DOI 10.1079/BJN20051638
   Ärnlöv J, 2009, DIABETOLOGIA, V52, P97, DOI 10.1007/s00125-008-1189-3
   Beydoun MA, 2011, J NUTR, V141, P903, DOI 10.3945/jn.110.136580
   Bisbal C, 2010, CURR OPIN CLIN NUTR, V13, P439, DOI 10.1097/MCO.0b013e32833a5559
   Borel P, 2007, J NUTR, V137, P2653, DOI 10.1093/jn/137.12.2653
   Calder PC, 2011, BRIT J NUTR, V106, pS1, DOI 10.1017/S0007114511005460
   Chai WW, 2010, NUTR RES, V30, P227, DOI 10.1016/j.nutres.2010.04.006
   Chaves GV, 2008, OBES SURG, V18, P378, DOI 10.1007/s11695-007-9361-2
   Chaves GV, 2010, INT J VITAM NUTR RES, V80, P159, DOI 10.1024/0300-9831/a000018
   Chung HY, 2009, AM J CLIN NUTR, V90, P533, DOI 10.3945/ajcn.2009.27712
   Coyne T, 2005, AM J CLIN NUTR, V82, P685, DOI 10.1093/ajcn/82.3.685
   Coyne T, 2009, BRIT J NUTR, V102, P1668, DOI 10.1017/S000711450999081X
   Czernichow S, 2009, AM J CLIN NUTR, V90, P329, DOI 10.3945/ajcn.2009.27635
   Feng D, 2010, INFLAMM RES, V59, P115, DOI 10.1007/s00011-009-0077-8
   Ford ES, 1999, AM J EPIDEMIOL, V149, P168, DOI 10.1093/oxfordjournals.aje.a009783
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Galan P, 2005, EUR J CLIN NUTR, V59, P1181, DOI 10.1038/sj.ejcn.1602230
   García OP, 2009, NUTR REV, V67, P559, DOI 10.1111/j.1753-4887.2009.00228.x
   Gouranton E, 2011, BBA-MOL CELL BIOL L, V1811, P1105, DOI 10.1016/j.bbalip.2011.09.002
   Gouranton E, 2011, J NUTR BIOCHEM, V22, P642, DOI 10.1016/j.jnutbio.2010.04.016
   Grattagliano I, 2008, J NUTR BIOCHEM, V19, P491, DOI 10.1016/j.jnutbio.2007.06.011
   Hozawa A, 2006, AM J EPIDEMIOL, V163, P929, DOI 10.1093/aje/kwj136
   Hozawa A, 2007, CLIN CHEM, V53, P447, DOI 10.1373/clinchem.2006.074930
   Kameji H, 2010, NUTRITION, V26, P1151, DOI 10.1016/j.nut.2009.09.006
   KAWADA T, 1990, COMP BIOCHEM PHYS A, V96, P323, DOI 10.1016/0300-9629(90)90699-S
   Kimmons Joel E, 2006, MedGenMed, V8, P59
   KURIHARCUCH W, 1982, DIFFERENTIATION, V23, P164, DOI 10.1111/j.1432-0436.1982.tb01279.x
   Landrier JF, 2012, NUTRIENTS, V4, P1622, DOI 10.3390/nu4111622
   Leal VD, 2013, CLIN CHIM ACTA, V419, P87, DOI 10.1016/j.cca.2013.02.003
   Lobo GP, 2010, J BIOL CHEM, V285, P27891, DOI 10.1074/jbc.M110.132571
   Bonet ML, 2012, BBA-MOL CELL BIOL L, V1821, P177, DOI 10.1016/j.bbalip.2011.06.001
   Marcotorchino J, 2012, MOL NUTR FOOD RES, V56, P725, DOI 10.1002/mnfr.201100623
   Namitha KK, 2010, CRIT REV FOOD SCI, V50, P728, DOI 10.1080/10408398.2010.499811
   Östh M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0085610
   de Heredia FP, 2012, P NUTR SOC, V71, P332, DOI 10.1017/S0029665112000092
   Rao AV, 2007, PHARMACOL RES, V55, P207, DOI 10.1016/j.phrs.2007.01.012
   Reboul E, 2011, PROG LIPID RES, V50, P388, DOI 10.1016/j.plipres.2011.07.001
   Sluijs I, 2009, J NUTR, V139, P987, DOI 10.3945/jn.108.101451
   Sugiura M, 2008, BRIT J NUTR, V100, P1297, DOI 10.1017/S0007114508978302
   Suzuki K, 2011, CLIN NUTR, V30, P369, DOI 10.1016/j.clnu.2010.12.006
   Suzuki K, 2010, CLIN CHIM ACTA, V411, P1330, DOI 10.1016/j.cca.2010.05.029
   Tourniaire F, 2009, GENES NUTR, V4, P179, DOI 10.1007/s12263-009-0128-3
   Turer AT, 2012, DIABETOLOGIA, V55, P2319, DOI 10.1007/s00125-012-2598-x
   Wang L, 2008, AM J CLIN NUTR, V88, P747, DOI 10.1093/ajcn/88.3.747
   Ylönen K, 2003, AM J CLIN NUTR, V77, P1434
   Ziouzenkova O, 2007, MOL ENDOCRINOL, V21, P77, DOI 10.1210/me.2006-0225
NR 48
TC 27
Z9 30
U1 0
U2 17
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD APR
PY 2015
VL 54
IS 3
BP 447
EP 454
DI 10.1007/s00394-014-0728-6
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CE0RO
UT WOS:000351513000012
PM 24906472
DA 2025-06-11
ER

PT J
AU Imenshahidi, M
   Karimi, G
   Hosseinzadeh, H
AF Imenshahidi, Mohsen
   Karimi, Golamreza
   Hosseinzadeh, Hossein
TI Effects of melatonin on cardiovascular risk factors and metabolic
   syndrome: a comprehensive review
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Review
DE Cardiovascular risk factors; Melatonin; Hypertension; Diabetes; Obesity;
   Metabolic syndrome
ID ISCHEMIA-REPERFUSION INJURY; SUSTAINED-RELEASE MELATONIN; HIGH-FAT DIET;
   BLOOD-PRESSURE; ENDOTHELIAL DYSFUNCTION; MYOCARDIAL-ISCHEMIA; OXIDATIVE
   STRESS; ARTERIAL-HYPERTENSION; GLUCOSE-METABOLISM; CARDIAC INJURY
AB Melatonin, as a neuroendocrine hormone, is produced primarily by the pineal gland. Melatonin, a pleotropic molecule, acts as a free radical scavenger, antioxidant, and regulator of circadian rhythm in mammals via several receptor-mediated and non-receptor-mediated mechanisms. This inexpensive, well-tolerated, and multi-target molecule has a great therapeutic potential against many diseases. Many evidences have proposed that melatonin plays a key role in the pathophysiology of various cardiovascular diseases. The aim of this paper is to discuss the data and experiments regarding the effects of melatonin in management of cardiovascular risk factors. PubMed, EMBASE, and Scopus have been searched for data collection using related keywords. Two hundred ten articles were included in this review from 2253 founded documents. Using these documents, the main mechanisms of action of melatonin are discussed and summarized in this article. Also, recent progresses regarding melatonin's effects on cardiovascular risk factors and diseases including diabetes, hypertension, hyperlipidemia, obesity, myocardial ischemia-reperfusion injury, pulmonary hypertension, and atherosclerosis have been reviewed. Many studies have demonstrated the beneficial effects of melatonin in prevention and improving cardiovascular risk factors, and this inexpensive and well-tolerated drug can be strongly proposed in different cardiovascular diseases as well as metabolic syndrome.
C1 [Imenshahidi, Mohsen; Karimi, Golamreza; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.
   [Imenshahidi, Mohsen; Karimi, Golamreza; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.; Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran.
EM hosseinzadehh@mums.ac.ir
RI Hosseinzadeh, Hossein/F-3013-2010
OI Hosseinzadeh, Hossein/0000-0002-3483-851X
CR Acuña-Castroviejo D, 2014, CELL MOL LIFE SCI, V71, P2997, DOI 10.1007/s00018-014-1579-2
   Ahmad Hajam Younis, 2018, Pak J Biol Sci, V21, P423, DOI 10.3923/pjbs.2018.423.431
   Akbari M, 2019, J HUM HYPERTENS, V33, P202, DOI 10.1038/s41371-019-0166-2
   Allagui MS, 2015, GEN PHYSIOL BIOPHYS, V34, P415, DOI 10.4149/gpb_2015028
   Andersson EA, 2010, DIABETES, V59, P1539, DOI 10.2337/db09-1757
   Asghari MH, 2017, ARCH TOXICOL, V91, DOI 10.1007/s00204-017-2029-3
   Astorga CR, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00185
   Bähr I, 2011, J PINEAL RES, V50, P336, DOI 10.1111/j.1600-079X.2010.00848.x
   Baker J, 2018, CLIN EXP PHARMACOL P, V45, P755, DOI 10.1111/1440-1681.12942
   Barrett TJ, 2017, ANN NY ACAD SCI, V1402, P31, DOI 10.1111/nyas.13462
   Benova T, 2013, CAN J PHYSIOL PHARM, V91, P633, DOI 10.1139/cjpp-2012-0393
   Beova T, 2015, CARDIOL LETT, V24, P60
   Bouchlariotou S, 2014, RENAL FAILURE, V36, P1001, DOI 10.3109/0886022X.2014.926216
   BRUGGER P, 1995, LANCET, V345, P1408, DOI 10.1016/S0140-6736(95)92600-3
   BUBENIK GA, 1994, J PINEAL RES, V16, P91, DOI 10.1111/j.1600-079X.1994.tb00088.x
   Butun I, 2013, BRATISL MED J, V114, P129, DOI 10.4149/BLL_2013_028
   CAPSONI S, 1994, ENDOCRINOLOGY, V135, P373, DOI 10.1210/en.135.1.373
   Cardinali DP, 2017, NEUROENDOCRINOLOGY, V104, P382, DOI 10.1159/000446543
   Carocci A, 2014, CLIN PHARMACOL-ADV A, V6, P127, DOI 10.2147/CPAA.S36600
   Cecon E, 2018, BRIT J PHARMACOL, V175, P3263, DOI 10.1111/bph.13950
   Celinski K, 2014, J PHYSIOL PHARMACOL, V65, P75
   Cheng XW, 2015, MOL MED REP, V11, P99, DOI 10.3892/mmr.2014.2753
   Cipolla-Neto J, 2014, J PINEAL RES, V56, P371, DOI 10.1111/jpi.12137
   Contreras-Alcantara S, 2010, OBESITY, V18, P1861, DOI 10.1038/oby.2010.24
   de Vries LJ, 2017, J CARDIOVASC PHARM, V70, P267, DOI 10.1097/FJC.0000000000000515
   Djordjevic B, 2018, EUR J PHARMACOL, V833, P290, DOI 10.1016/j.ejphar.2018.06.011
   Dominguez-Rodriguez A, 2016, INT J CARDIOL, V221, P359, DOI 10.1016/j.ijcard.2016.07.056
   Dominguez-Rodriguez A, 2010, AM J CARDIOL, V106, P1540, DOI 10.1016/j.amjcard.2010.07.030
   Doosti-Irani A, 2018, HORM METAB RES, V50, P783, DOI 10.1055/a-0752-8462
   dos Santos RM, 2018, LIFE SCI, V213, P32, DOI 10.1016/j.lfs.2018.09.056
   Dubielski Z, 2016, ARTER HYPERTENS, V20, P33, DOI 10.5603/AH.2016.0007
   DUBOCOVICH ML, 1995, TRENDS PHARMACOL SCI, V16, P50, DOI 10.1016/S0165-6147(00)88978-6
   Ediz SM, 2015, EUR J PHARMACOL, V762, P214, DOI 10.1016/j.ejphar.2015.04.054
   Ekmekcioglu C, 2006, BIOMED PHARMACOTHER, V60, P97, DOI 10.1016/j.biopha.2006.01.002
   Emet M, 2016, EURASIAN J MED, V48, P135, DOI 10.5152/eurasianjmed.2015.0267
   Espino J, 2011, WORLD J DIABETES, V2, P82, DOI 10.4239/wjd.v2.i6.82
   Fathollahi Ali, 2015, Curr Urol, V8, P113, DOI 10.1159/000365701
   Favero G, 2015, NUTR RES, V35, P891, DOI 10.1016/j.nutres.2015.07.001
   Foley HM, 2019, COMPLEMENT THER MED, V42, P65, DOI 10.1016/j.ctim.2018.11.003
   Galley HF, 2014, J PINEAL RES, V56, P427, DOI 10.1111/jpi.12134
   Garakyaraghi M, 2012, J RES MED SCI, V17, pS13
   Gerush I. V., 2018, Ukrainian Biochemical Journal, V90, P62, DOI 10.15407/ubj90.03.062
   Ghaeli P, 2015, IRAN J PHARM RES, V14, P851
   Godo S, 2017, ARTERIOSCL THROM VAS, V37, pE108, DOI 10.1161/ATVBAHA.117.309813
   Domingos ALG, 2019, CRIT REV FOOD SCI, V59, P133, DOI 10.1080/10408398.2017.1360837
   Green EA, 2014, CARDIOVASC THER, V32, P105, DOI 10.1111/1755-5922.12067
   Gubin D, 2020, BIOL RHYTHM RES, V51, P780, DOI 10.1080/09291016.2018.1564586
   Gubin Denis G, 2016, Curr Aging Sci, V9, P5
   Han D, 2016, J PINEAL RES, V60, P178, DOI 10.1111/jpi.12299
   Heo JI, 2018, J PINEAL RES, V65, DOI 10.1111/jpi.12493
   Hu ZP, 2013, J PINEAL RES, V55, P388, DOI 10.1111/jpi.12085
   Hung MW, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18061125
   Hung MW, 2013, J PINEAL RES, V55, P247, DOI 10.1111/jpi.12067
   Ilhan S, 2015, TOXICOL IND HEALTH, V31, P298, DOI 10.1177/0748233712472521
   Jockers R, 2016, BRIT J PHARMACOL, V173, P2702, DOI 10.1111/bph.13536
   Prado NJ, 2018, J PINEAL RES, V65, DOI 10.1111/jpi.12513
   Prado NJ, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0842-6
   Kandemir YB, 2018, CELL MOL BIOL, V64, P47, DOI 10.14715/cmb/2018.64.14.8
   Kantar S, 2015, PHARM BIOL, V53, P1035, DOI 10.3109/13880209.2014.957782
   Klimentova J, 2016, PHYSIOL RES, V65, pS373, DOI 10.33549/physiolres.933436
   Kurhaluk N, 2018, ADV EXP MED BIOL, V1047, P7, DOI 10.1007/5584_2017_128
   Lardone PJ, 2014, CURR PHARM DESIGN, V20, P4841
   Li HY, 2019, J AGR FOOD CHEM, V67, P1889, DOI 10.1021/acs.jafc.8b06217
   Li YL, 2018, INT J MOL MED, V41, P955, DOI 10.3892/ijmm.2017.3305
   Lochner Amanda, 2013, Front Biosci (Elite Ed), V5, P305
   Ma S, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/9286458
   Maarman G, 2015, J PINEAL RES, V59, P343, DOI 10.1111/jpi.12263
   Masri FA, 2008, CTS-CLIN TRANSL SCI, V1, P99, DOI 10.1111/j.1752-8062.2008.00035.x
   Mayo JC, 2018, MOLECULES, V23, DOI 10.3390/molecules23081999
   McMullan CJ, 2017, HEART, V103, P694, DOI 10.1136/heartjnl-2016-310098
   Moore RY, 1996, BEHAV BRAIN RES, V73, P125
   Mozaffari S, 2012, INT J PHARMACOL, V8, P496, DOI 10.3923/ijp.2012.496.509
   Mozos I, 2017, SHIFT WORK IMPACTS D, P23
   Mukherjee D, 2012, J PINEAL RES, V53, P166, DOI 10.1111/j.1600-079X.2012.00984.x
   Navarro-Alarcón M, 2014, FOOD FUNCT, V5, P2806, DOI [10.1039/C4FO00317A, 10.1039/c4fo00317a]
   Nduhirabandi F, 2017, CARDIOVASC J AFR, V28, P362, DOI 10.5830/CVJA-2017-018
   Nduhirabandi F, 2014, J PINEAL RES, V57, P317, DOI 10.1111/jpi.12171
   Nduhirabandi F, 2011, J PINEAL RES, V50, P171, DOI 10.1111/j.1600-079X.2010.00826.x
   Nosjean O, 2000, J BIOL CHEM, V275, P31311, DOI 10.1074/jbc.M005141200
   Obayashi K, 2013, J CLIN ENDOCR METAB, V98, P337, DOI 10.1210/jc.2012-2874
   Pandi-Perumal SR, 2008, PROG NEUROBIOL, V85, P335, DOI 10.1016/j.pneurobio.2008.04.001
   Pandi-Perumal SR, 2017, J CARDIOVASC PHARM T, V22, P122, DOI 10.1177/1074248416660622
   Paulis L, 2012, EXPERT OPIN INV DRUG, V21, P1661, DOI 10.1517/13543784.2012.714771
   Paulis L, 2010, J HYPERTENS, V28, pS19, DOI 10.1097/01.hjh.0000388490.28213.de
   Pechanova O, 2016, ACT NERV SUPER REDIV, V58, P99
   Pechanova O, 2014, INT J MOL SCI, V15, P17920, DOI 10.3390/ijms151017920
   Peschke E, 2015, J PINEAL RES, V59, P1, DOI 10.1111/jpi.12240
   Rahbari-Oskoui FF, 2019, COMPLEMENT THER MED, V43, P157, DOI 10.1016/j.ctim.2019.01.026
   Raygan F, 2019, CLIN NUTR, V38, P191, DOI 10.1016/j.clnu.2017.12.004
   Reiter RJ, 2003, CARDIOVASC RES, V58, P10, DOI 10.1016/S0008-6363(02)00827-1
   Reiter RJ, 1999, MECH AGEING DEV, V110, P157, DOI 10.1016/S0047-6374(99)00058-5
   Reiter RJ, 2018, MOLECULES, V23, DOI 10.3390/molecules23020509
   Reutrakul Sirimon, 2018, Neurobiology of Sleep and Circadian Rhythms, V4, P10, DOI 10.1016/j.nbscr.2017.06.001
   Rexhaj E, 2015, AM J PHYSIOL-HEART C, V309, pH1151, DOI 10.1152/ajpheart.00621.2014
   Rezvanfar MR, 2017, INT J DIABETES DEV C, V37, P74, DOI 10.1007/s13410-016-0497-2
   Richard D, 2011, FRONT BIOSCI-LANDMRK, V16, P1233, DOI 10.2741/3786
   Ríos-Lugo MJ, 2010, J PINEAL RES, V49, P342, DOI 10.1111/j.1600-079X.2010.00798.x
   Rodella Luigi Fabrizio, 2013, Front Biosci (Elite Ed), V5, P119
   Roohbakhsh A, 2018, PHARMACOL RES, V133, P265, DOI 10.1016/j.phrs.2018.01.022
   Rubio-Sastre P, 2014, SLEEP, V37, P1715, DOI 10.5665/sleep.4088
   Rybka J, 2016, DRUG DELIV, V23, P814, DOI 10.3109/10717544.2014.917343
   Sakotnik A, 1999, EUR HEART J, V20, P1314, DOI 10.1053/euhj.1999.1527
   Salari Lak L, 2011, IRAN J ENDOCRINOL ME, V13, P406
   Salmanoglu DS, 2016, REDOX BIOL, V8, P199, DOI 10.1016/j.redox.2015.11.007
   Scheer FAJL, 2004, HYPERTENSION, V43, P192, DOI 10.1161/01.HYP.0000113293.15186.3b
   Sharma S, 2015, ARCH ENDOCRIN METAB, V59, P391, DOI 10.1590/2359-3997000000098
   Simko F, 2018, MOLECULES, V23, DOI 10.3390/molecules23020265
   Simko F, 2016, J PINEAL RES, V61, P127, DOI 10.1111/jpi.12348
   Simko F, 2014, J PINEAL RES, V57, P177, DOI 10.1111/jpi.12154
   Simko F, 2014, MEDIAT INFLAMM, V2014, DOI 10.1155/2014/703175
   Simoes D, 2016, J ENDOCRINOL, V231, P235, DOI 10.1530/JOE-16-0259
   Slominski AT, 2017, EXP DERMATOL, V26, P563, DOI 10.1111/exd.13208
   Slominski RM, 2012, MOL CELL ENDOCRINOL, V351, P152, DOI 10.1016/j.mce.2012.01.004
   STANKOV B, 1993, NEUROSCIENCE, V52, P459, DOI 10.1016/0306-4522(93)90172-C
   Su HY, 2017, ARCH MED RES, V48, P526, DOI 10.1016/j.arcmed.2017.12.003
   Sun H, 2018, INT J ENDOCRINOL, V2018, DOI 10.1155/2018/2304746
   Tain YL, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101407
   Tain YL, 2018, MOLECULES, V23, DOI 10.3390/molecules23040886
   Tain YL, 2016, AM J OBSTET GYNECOL, V215, DOI 10.1016/j.ajog.2016.07.036
   Tain YL, 2010, J PINEAL RES, V49, P390, DOI 10.1111/j.1600-079X.2010.00806.x
   Tan DX, 2011, OBES REV, V12, P167, DOI 10.1111/j.1467-789X.2010.00756.x
   Tan DX, 2015, MOLECULES, V20, P18886, DOI 10.3390/molecules201018886
   Tang ST, 2016, J CARDIOVASC PHARM T, V21, P82, DOI 10.1177/1074248415583090
   Thomas RL, 2013, GENE DEV, V27, P1365, DOI 10.1101/gad.215871.113
   Torres F, 2015, J PINEAL RES, V58, P362, DOI 10.1111/jpi.12222
   van der Zwan LP, 2010, HYPERTENSION, V56, pE34, DOI 10.1161/HYPERTENSIONAHA.110.158170
   Virto L, 2018, J CLIN PERIODONTOL, V45, P1336, DOI 10.1111/jcpe.13013
   Vonk-Noordegraaf A, 2013, J AM COLL CARDIOL, V62, pD22, DOI 10.1016/j.jacc.2013.10.027
   Wang ZQ, 2016, J PINEAL RES, V60, P217, DOI 10.1111/jpi.12305
   Weishaupt JH, 2006, J PINEAL RES, V41, P313, DOI 10.1111/j.1600-079X.2006.00377.x
   Xiong FY, 2018, MOL MED REP, V17, P374, DOI 10.3892/mmr.2017.7841
   Xu J, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-05752-9
   Xu PF, 2017, J PINEAL RES, V62, DOI 10.1111/jpi.12399
   Yang GH, 2014, J PINEAL RES, V57, P451, DOI 10.1111/jpi.12185
   Yaprak M, 2003, INT J CARDIOL, V89, P103, DOI 10.1016/S0167-5273(02)00461-8
   Yin J, 2018, J PINEAL RES, V65, DOI 10.1111/jpi.12524
   Yu LM, 2017, J PINEAL RES, V62, DOI 10.1111/jpi.12375
   Yu LM, 2015, J PINEAL RES, V59, P420, DOI 10.1111/jpi.12272
   Yu LM, 2015, J PINEAL RES, V59, P376, DOI 10.1111/jpi.12269
   Zaglia T, 2014, J CLIN INVEST, V124, P2410, DOI 10.1172/JCI66339
   ZANOBONI A, 1978, J ENDOCRINOL INVEST, V1, P125, DOI 10.1007/BF03350359
   Zanuto R, 2013, J PINEAL RES, V55, P156, DOI 10.1111/jpi.12056
   Zeman M, 2005, LIFE SCI, V76, P1795, DOI 10.1016/j.lfs.2004.08.034
   Zhang MM, 2017, J PINEAL RES, V63, DOI 10.1111/jpi.12418
   Zhao YiWen Zhao YiWen, 2017, Scientia Agricultura Sinica, V50, P3429
   Zhou H, 2018, CELL SIGNAL, V47, P88, DOI 10.1016/j.cellsig.2018.03.012
   Zhou J, 2018, J PHARMACOL EXP THER, V364, P55, DOI 10.1124/jpet.117.243998
   Zhu HQ, 2014, INT J CARDIOL, V176, P764, DOI 10.1016/j.ijcard.2014.07.095
   Zhu P, 2015, J CELL MOL MED, V19, P2232, DOI 10.1111/jcmm.12610
NR 149
TC 46
Z9 50
U1 1
U2 32
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD APR
PY 2020
VL 393
IS 4
BP 521
EP 536
DI 10.1007/s00210-020-01822-4
EA JAN 2020
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA KU4GP
UT WOS:000510287600002
PM 32002576
DA 2025-06-11
ER

PT J
AU Naseri, R
   Farzaei, F
   Haratipour, P
   Nabavi, SF
   Habtemariam, S
   Farzaei, MH
   Khodarahmi, R
   Tewari, D
   Momtaz, S
AF Naseri, Rozita
   Farzaei, Fatemeh
   Haratipour, Pouya
   Nabavi, Seyed Fazel
   Habtemariam, Solomon
   Farzaei, Mohammad Hosein
   Khodarahmi, Reza
   Tewari, Devesh
   Momtaz, Saeideh
TI Anthocyanins in the Management of Metabolic Syndrome: A Pharmacological
   and Biopharmaceutical Review
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE anthocyanins; natural pigments; phytochemicals; metabolic syndrome;
   diabetes mellitus; insulin resistance
ID POMEGRANATE PUNICA-GRANATUM; ACTIVATED PROTEIN-KINASE; POLYPHENOL-RICH
   EXTRACT; OXIDATIVE STRESS; INSULIN-RESISTANCE; ANTIOXIDANT ACTIVITY;
   IN-VITRO; CARDIOVASCULAR-DISEASE; ARONIA-MELANOCARPA; NITRIC-OXIDE
AB The term "metabolic syndrome" (MetS) refers to a combination of diabetes, high blood pressure, and obesity. The origin of MetS includes a combination of multiple factors, such as sedentary lifestyle, unhealthy diet choice, and genetic factors. MetS is highly prevalent and adversely affects the general population by elevating risk of cardiovascular complications, organ failure, and much other pathology associated with late-stage diabetes. Anthocyanins (ANTs) are health-promoting bioactive compounds belonging to the flavonoids subclass of polyphenols. Numerous studies have reported the potential therapeutic benefits on MetS syndrome and diabetes from fruits rich in ANTs. This review summarizes the role of several dietary ANTs on preventing and managing MetS as well as the pharmacological mechanisms and biopharmaceutical features of their action. We also discuss potential nanoformulation and encapsulation approaches that may enhance the bioefficacy of ANTs in MetS. Experiments have demonstrated that ANTs may attenuate the symptoms of MetS via improving insulin resistance, impaired glucose tolerance, dyslipidaemia, cholesterol levels, hypertension, blood glucose, protecting beta cells, and preventing free radical production. In brief, the intake of ANT-rich supplements should be considered due to their plausible ability for prevention and management of MetS. Additionally, randomized double-blind clinical trials are obligatory for evaluating the bioefficacy and pharmacological mechanisms of ANTs and their pharmaceutical formulations in patients with MetS.
C1 [Naseri, Rozita] Kermanshah Univ Med Sci, Sch Med, Internal Med Dept, Kermanshah, Iran.
   [Farzaei, Fatemeh; Farzaei, Mohammad Hosein] Kermanshah Univ Med Sci, Pharmaceut Sci Res Ctr, Kermanshah, Iran.
   [Haratipour, Pouya] Sharif Univ Technol, Dept Chem, Tehran, Iran.
   [Haratipour, Pouya] Universal Sci Educ & Res Network, Phyto Pharmacol Interest Grp, Los Angeles, CA USA.
   [Nabavi, Seyed Fazel] Baqiyatallah Univ Med Sci, Appl Biotechnol Res Ctr, Tehran, Iran.
   [Habtemariam, Solomon] Univ Greenwich, Medway Sch Sci, Pharmacognosy Res Labs, Kent, England.
   [Khodarahmi, Reza] Kermanshah Univ Med Sci, Med Biol Res Ctr, Kermanshah, Iran.
   [Tewari, Devesh] Kumaun Univ, Fac Technol, Dept Pharmaceut Sci, Naini Tal, India.
   [Momtaz, Saeideh] ACECR, Inst Med Plants, Med Plants Res Ctr, Karaj, Iran.
   [Momtaz, Saeideh] Univ Tehran Med Sci, Inst Pharmaceut Sci, Toxicol & Dis Grp, Tehran, Iran.
C3 Kermanshah University of Medical Sciences; Kermanshah University of
   Medical Sciences; Sharif University of Technology; Baqiyatallah
   University of Medical Sciences (BMSU); University of Greenwich;
   Kermanshah University of Medical Sciences; Kumaun University; Academic
   Center for Education, Culture & Research (ACECR); Tehran University of
   Medical Sciences
RP Farzaei, MH (corresponding author), Kermanshah Univ Med Sci, Pharmaceut Sci Res Ctr, Kermanshah, Iran.; Khodarahmi, R (corresponding author), Kermanshah Univ Med Sci, Med Biol Res Ctr, Kermanshah, Iran.
EM mh.farzaei@gmail.com; rkhodarahmi@mbrc.ac.ir
RI Nabavi, Seyed Mohammad/G-5335-2010; Naseri, Rozita/M-8174-2017; Tewari,
   Devesh/P-9954-2019; Farzaei, Mohammad/M-5779-2017; Haratipour,
   Pouya/J-9454-2017; Khodarahmi, Reza/S-2685-2017; Stefanadis,
   Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454
FU Kermanshah University of Medical Sciences
FX This work will be supported, financially, by Kermanshah University of
   Medical Sciences.
CR Abete I, 2011, NUTR METAB CARDIOVAS, V21, pB1, DOI 10.1016/j.numecd.2011.05.001
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Alvarado Jorge, 2016, Panminerva Med, V58, P1
   American Diabetes Association, 2009, INTRODUCTION
   Amiot MJ, 2016, OBES REV, V17, P573, DOI 10.1111/obr.12409
   Amirkalali B, 2015, IRAN RED CRESCENT ME, V17, DOI 10.5812/ircmj.24723
   Amorini AM, 2001, FREE RADICAL RES, V35, P953, DOI 10.1080/10715760100301451
   Andersen OM, 2004, PHYTOCHEMISTRY, V65, P405, DOI 10.1016/j.phytochem.2003.10.014
   ANDERSON O.M., 2008, P 5 INT C PIGM FOOD, P14
   [Anonymous], 2012, Teas, Cocoa and Coffee: Plant Secondary Metabolites and Health
   Aviram M, 2001, ATHEROSCLEROSIS, V158, P195, DOI 10.1016/S0021-9150(01)00412-9
   Aviram M, 2000, AM J CLIN NUTR, V71, P1062
   Bagchi D, 2004, BIOCHEMISTRY-MOSCOW+, V69, P75, DOI 10.1023/B:BIRY.0000016355.19999.93
   Barazzoni R, 2018, EAT WEIGHT DISORD-ST, V23, P149, DOI 10.1007/s40519-018-0481-6
   Basu A, 2010, NUTR RES, V30, P462, DOI 10.1016/j.nutres.2010.06.016
   Berlin E, 2000, DIABETES METABOL, V26, P178
   Bognar E, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0065355
   Broncel Marlena, 2007, Pol Merkur Lekarski, V23, P116
   Bub A, 2001, EUR J NUTR, V40, P113, DOI 10.1007/s003940170011
   Burns J, 2000, J AGR FOOD CHEM, V48, P220, DOI 10.1021/jf9909757
   Cao GH, 1998, J NUTR, V128, P2383, DOI 10.1093/jn/128.12.2383
   Carr DB, 2004, DIABETES, V53, P2087, DOI 10.2337/diabetes.53.8.2087
   Castro-Acosta ML, 2017, J NUTR BIOCHEM, V49, P53, DOI 10.1016/j.jnutbio.2017.07.013
   Cerdá B, 2004, EUR J NUTR, V43, P205, DOI 10.1007/s00394-004-0461-7
   CHERIAN S, 1992, INDIAN J BIOCHEM BIO, V29, P380
   Çoban J, 2013, BIOSCI BIOTECH BIOCH, V77, P389, DOI 10.1271/bbb.120722
   Corzo-Martínez M, 2007, TRENDS FOOD SCI TECH, V18, P609, DOI 10.1016/j.tifs.2007.07.011
   Czank C, 2013, AM J CLIN NUTR, V97, P995, DOI 10.3945/ajcn.112.049247
   d'Alessandro LG, 2012, SEP PURIF TECHNOL, V93, P42, DOI 10.1016/j.seppur.2012.03.024
   Day Caroline, 2007, Diab Vasc Dis Res, V4, P32, DOI 10.3132/dvdr.2007.003
   de Ferrars RM, 2014, BRIT J PHARMACOL, V171, P3268, DOI 10.1111/bph.12676
   DeFuria J, 2009, J NUTR, V139, P1510, DOI 10.3945/jn.109.105155
   Deng GF, 2013, CRIT REV FOOD SCI, V53, P296, DOI 10.1080/10408398.2010.529624
   Desroches S, 2007, APPL PHYSIOL NUTR ME, V32, P23, DOI 10.1139/h06-095
   Di Gregorio GB, 2005, DIABETES, V54, P2305, DOI 10.2337/diabetes.54.8.2305
   Dreiseitel A, 2008, BIOCHEM BIOPH RES CO, V372, P57, DOI 10.1016/j.bbrc.2008.04.140
   Du CY, 2015, DRUG DES DEV THER, V9, DOI 10.2147/DDDT.S90201
   Eldin IMT, 2010, ENVIRON HEALTH INSIG, V4, P71, DOI 10.4137/EHI.S5540
   Elks CM, 2015, OBESITY, V23, P573, DOI 10.1002/oby.20926
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   Fang J, 2015, NUTRITION, V31, P1301, DOI 10.1016/j.nut.2015.04.015
   Farzaei F, 2017, J EVID-BASED INTEGR, V22, P944, DOI 10.1177/2156587216686461
   Farzaei MH, 2018, EXPERT REV GASTROENT, V12, P1007, DOI 10.1080/17474124.2018.1513322
   Favaro-Trindade CS, 2010, FOOD HYDROCOLLOID, V24, P336, DOI 10.1016/j.foodhyd.2009.10.012
   Felgines C, 2002, J NUTR, V132, P1249, DOI 10.1093/jn/132.6.1249
   Fernandes I, 2014, J FUNCT FOODS, V7, P54, DOI 10.1016/j.jff.2013.05.010
   Feshani AM, 2011, J ETHNOPHARMACOL, V133, P67, DOI 10.1016/j.jep.2010.09.002
   Festa A, 2001, INT J OBESITY, V25, P1407, DOI 10.1038/sj.ijo.0801792
   Flores FP, 2013, J AGR FOOD CHEM, V61, P4441, DOI 10.1021/jf400429f
   Folmer V, 2002, INT J BIOCHEM CELL B, V34, P1279, DOI 10.1016/S1357-2725(02)00065-1
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Frejnagel SS, 2008, POL J VET SCI, V11, P125
   Friedman JM, 1998, NATURE, V395, P763, DOI 10.1038/27376
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gil MI, 2000, J AGR FOOD CHEM, V48, P4581, DOI 10.1021/jf000404a
   Gluckman PD, 2004, TRENDS ENDOCRIN MET, V15, P183, DOI 10.1016/j.tem.2004.03.002
   González-Barrio R, 2011, DRUG METAB DISPOS, V39, P1680, DOI 10.1124/dmd.111.039651
   González-Barrio R, 2010, J AGR FOOD CHEM, V58, P3933, DOI 10.1021/jf100315d
   Grewal AS, 2016, MED CHEM, V12, P3
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Gurrola-Díaz CM, 2010, PHYTOMEDICINE, V17, P500, DOI 10.1016/j.phymed.2009.10.014
   Hämäläinen M, 2007, MEDIAT INFLAMM, V2007, DOI 10.1155/2007/45673
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Hassimotto NMA, 2008, NUTR RES, V28, P198, DOI 10.1016/j.nutres.2007.12.012
   Hawley SA, 2002, DIABETES, V51, P2420, DOI 10.2337/diabetes.51.8.2420
   He J, 2006, NUTR CANCER, V54, P3, DOI 10.1207/s15327914nc5401_2
   He YQ, 2017, ENVIRON TOXICOL PHAR, V56, P56, DOI 10.1016/j.etap.2017.08.035
   Henagan TM, 2015, GENES NUTR, V10, DOI 10.1007/s12263-014-0451-1
   Hidalgo J, 2014, Panminerva Med, V56, P1
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Hu C, 2003, J AGR FOOD CHEM, V51, P5271, DOI 10.1021/jf034466n
   Huang Hui-Pei, 2013, J Tradit Complement Med, V3, P7, DOI 10.4103/2225-4110.106535
   Huang TW, 2015, FOOD NUTR RES, V59, DOI 10.3402/fnr.v59.29018
   Huang WY, 2014, MOLECULES, V19, P12827, DOI 10.3390/molecules190812827
   Ichiyanagi T, 2005, J AGR FOOD CHEM, V53, P7312, DOI 10.1021/jf051002b
   Ichiyanagi T, 2004, FREE RADICAL BIO MED, V36, P930, DOI 10.1016/j.freeradbiomed.2004.01.005
   Guzmán-Gerónimo RI, 2017, J MED FOOD, V20, P110, DOI [10.1089/jmf.2016.0087, 10.1089/jmf.2016.3851]
   Iwaki M, 2003, DIABETES, V52, P1655, DOI 10.2337/diabetes.52.7.1655
   Jeon YD, 2018, J MED FOOD, V21, P244, DOI 10.1089/jmf.2017.3939
   Johnson MH, 2011, J AGR FOOD CHEM, V59, P8923, DOI 10.1021/jf201720z
   Jung JY, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-18
   Jurgonski A, 2008, PLANT FOOD HUM NUTR, V63, P176, DOI 10.1007/s11130-008-0087-7
   Kalea AZ, 2009, J MED FOOD, V12, P21, DOI 10.1089/jmf.2008.0078
   Kalt W, 2017, FOOD FUNCT, V8, P4563, DOI [10.1039/c7fo01074e, 10.1039/C7FO01074E]
   Kamiloglu S, 2015, INT J MOL SCI, V16, P21555, DOI 10.3390/ijms160921555
   Kaplan M, 2001, J NUTR, V131, P2082, DOI 10.1093/jn/131.8.2082
   Kastorini CM, 2011, J AM COLL CARDIOL, V57, P1299, DOI 10.1016/j.jacc.2010.09.073
   Kaul K, 2013, ADV EXP MED BIOL, V771, P1
   Kay CD, 2006, NUTR RES REV, V19, P137, DOI 10.1079/NRR2005116
   Kay CD, 2017, ANNU REV FOOD SCI T, V8, P155, DOI 10.1146/annurev-food-030216-025636
   Kim B, 2013, NUTR RES, V33, P406, DOI 10.1016/j.nutres.2013.03.001
   Kim HJ, 2006, FEBS LETT, V580, P1391, DOI 10.1016/j.febslet.2006.01.062
   Kim H, 2018, FOOD FUNCT, V9, P3097, DOI 10.1039/c8fo00595h
   Kolovou GD, 2007, AM J MED SCI, V333, P362, DOI 10.1097/MAJ.0b013e318065c3a1
   Kudva Yogish C., 1997, P119
   Kulling SE, 2008, PLANTA MED, V74, P1625, DOI 10.1055/s-0028-1088306
   Kumar B, 2012, PHYTOTHER RES, V26, P488, DOI 10.1002/ptr.3584
   Kumari Kumud, 2002, Indian Journal of Experimental Biology, V40, P1005
   Kusano S, 2000, BIOL PHARM BULL, V23, P23, DOI 10.1248/bpb.23.23
   Kusano S, 2001, BIOSCI BIOTECH BIOCH, V65, P109, DOI 10.1271/bbb.65.109
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lakka TA, 2007, APPL PHYSIOL NUTR ME, V32, P76, DOI 10.1139/h06-113
   Lara-Castro C, 2006, DIABETES, V55, P249, DOI 10.2337/diabetes.55.01.06.db05-1105
   Lau FC, 2007, J NEUROSCI RES, V85, P1010, DOI 10.1002/jnr.21205
   Lee JS, 2015, MOL MED REP, V11, P2723, DOI 10.3892/mmr.2014.3078
   Leyva F, 1998, ARTERIOSCL THROM VAS, V18, P928, DOI 10.1161/01.ATV.18.6.928
   LIETTI A, 1976, ARZNEIMITTEL-FORSCH, V26, P829
   Liu YN, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0127813
   Louwen F, 2018, OBES REV, V19, P888, DOI 10.1111/obr.12679
   Ludvik B, 2008, DIABETES OBES METAB, V10, P586, DOI 10.1111/j.1463-1326.2007.00752.x
   Ludvik B, 2004, DIABETES CARE, V27, P436, DOI 10.2337/diacare.27.2.436
   Ludwig IA, 2015, FREE RADICAL BIO MED, V89, P758, DOI 10.1016/j.freeradbiomed.2015.10.400
   Maddux BA, 2001, DIABETES, V50, P404, DOI 10.2337/diabetes.50.2.404
   Maiese K, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/875961
   Maksimov ML, 2016, CURR PHARM DESIGN, V22, P895, DOI 10.2174/1381612822666151209153047
   Markakis P., 2012, Anthocyanins as Food Colors
   Martineau LC, 2006, PHYTOMEDICINE, V13, P612, DOI 10.1016/j.phymed.2006.08.005
   Martínez-Abundis E, 2016, WORLD J DIABETES, V7, P142, DOI 10.4239/wjd.v7.i7.142
   Marvasti TB, 2010, DARU, V18, P146
   Mathew P T, 1975, Indian J Physiol Pharmacol, V19, P213
   Matsiu T, 2002, J AGR FOOD CHEM, V50, P7244, DOI 10.1021/jf025913m
   Matsuzawa Y, 1999, ANN NY ACAD SCI, V892, P146, DOI 10.1111/j.1749-6632.1999.tb07793.x
   Merone L, 2017, DIABETES RES CLIN PR, V127, P238, DOI 10.1016/j.diabres.2017.02.019
   Mirshekar Mohammadali, 2010, Iran Biomed J, V14, P33
   Montagne CT, 2000, DIABETES, V49, P883, DOI 10.2337/diabetes.49.6.883
   Morazzoni P., 1996, Fitoterapia, V67, P3
   Mueller D, 2018, FOOD CHEM, V248, P217, DOI 10.1016/j.foodchem.2017.12.058
   Munasinghe PE, 2016, INT J CLIN EXP PHYSL, V3, P155, DOI [10.4103/2348-8832.196893, DOI 10.4103/2348-8832.196893]
   Murthy KNC, 2002, J AGR FOOD CHEM, V50, P4791, DOI 10.1021/jf0255735
   Nayak CA, 2010, DRY TECHNOL, V28, P1396, DOI 10.1080/07373937.2010.482705
   Niemann B, 2017, J AM COLL CARDIOL, V70, P230, DOI 10.1016/j.jacc.2017.05.043
   Olas B, 2008, J PHYSIOL PHARMACOL, V59, P823
   Passamonti S, 2003, FEBS LETT, V544, P210, DOI 10.1016/S0014-5793(03)00504-0
   Pergola C, 2006, NITRIC OXIDE-BIOL CH, V15, P30, DOI 10.1016/j.niox.2005.10.003
   Pinto MDS, 2008, J AGR FOOD CHEM, V56, P4386, DOI 10.1021/jf0732758
   Pojer E, 2013, COMPR REV FOOD SCI F, V12, P483, DOI 10.1111/1541-4337.12024
   Prior RL, 2001, J AGR FOOD CHEM, V49, P1270, DOI 10.1021/jf001211q
   Prior RL, 2010, J AGR FOOD CHEM, V58, P3977, DOI 10.1021/jf9030772
   Qin BL, 2012, BRIT J NUTR, V108, P581, DOI 10.1017/S000711451100599X
   Qin Y, 2009, AM J CLIN NUTR, V90, P485, DOI 10.3945/ajcn.2009.27814
   Reho JJ, 2017, CLIN SCI, V131, P1689, DOI 10.1042/CS20170219
   RENAUD S, 1992, LANCET, V339, P1523, DOI 10.1016/0140-6736(92)91277-F
   Robert P, 2010, INT J FOOD SCI TECH, V45, P1386, DOI 10.1111/j.1365-2621.2010.02270.x
   Rojo LE, 2012, FOOD CHEM, V131, P387, DOI 10.1016/j.foodchem.2011.08.066
   Romeo GR, 2012, ARTERIOSCL THROM VAS, V32, P1771, DOI 10.1161/ATVBAHA.111.241869
   Routray W, 2011, COMPR REV FOOD SCI F, V10, P303, DOI 10.1111/j.1541-4337.2011.00164.x
   Roy M, 2008, LIFE SCI, V82, P1102, DOI 10.1016/j.lfs.2008.03.011
   Russell JC, 2006, CARDIOVASC PATHOL, V15, P318, DOI 10.1016/j.carpath.2006.09.001
   Samadder A, 2017, PLANTA MED, V83, P468, DOI 10.1055/s-0043-100017
   Samadder A, 2016, ENVIRON TOXICOL PHAR, V43, P27, DOI 10.1016/j.etap.2016.02.010
   Scazzocchio B, 2011, DIABETES, V60, P2234, DOI 10.2337/db10-1461
   Schmeichel AM, 2003, DIABETES, V52, P165, DOI 10.2337/diabetes.52.1.165
   Schreckinger ME, 2010, J AGR FOOD CHEM, V58, P8966, DOI 10.1021/jf100975m
   Schröder H, 2007, J NUTR BIOCHEM, V18, P149, DOI 10.1016/j.jnutbio.2006.05.006
   Schubert SY, 1999, J ETHNOPHARMACOL, V66, P11, DOI 10.1016/S0378-8741(98)00222-0
   Seeram NP, 2006, J NUTR, V136, P2481, DOI 10.1093/jn/136.10.2481
   Seeram NP, 2002, J AGR FOOD CHEM, V50, P2519, DOI 10.1021/jf0115903
   Sellappan S, 2002, J AGR FOOD CHEM, V50, P2432, DOI 10.1021/jf011097r
   Seymour EM, 2008, J MED FOOD, V11, P252, DOI 10.1089/jmf.2007.658
   Shamim U., 2009, THESIS
   Shimomura I, 1996, NAT MED, V2, P800, DOI 10.1038/nm0796-800
   Shirode AB, 2015, INT J NANOMED, V10, P475, DOI 10.2147/IJN.S65145
   Simeonov Simeon B, 2002, Folia Med (Plovdiv), V44, P20
   Skates E, 2018, FOOD CHEM TOXICOL, V111, P445, DOI 10.1016/j.fct.2017.11.032
   Skoczynska A, 2007, PHARMACOL REP, V59, P177
   Sodagari HR, 2015, EXPERT REV GASTROENT, V9, P807, DOI 10.1586/17474124.2015.1002086
   Spiegelman BM, 2001, CELL, V104, P531, DOI 10.1016/S0092-8674(01)00240-9
   Steed LE, 2008, J FOOD SCI, V73, pS215, DOI 10.1111/j.1750-3841.2008.00774.x
   Steppan CM, 2001, NATURE, V409, P307, DOI 10.1038/35053000
   Sundaram RK, 1996, CLIN SCI, V90, P255, DOI 10.1042/cs0900255
   Suzuki R, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-14
   Taniguchi CM, 2006, NAT REV MOL CELL BIO, V7, P85, DOI 10.1038/nrm1837
   Thibado SP, 2018, MOL CLIN ONCOL, V8, P330, DOI 10.3892/mco.2017.1520
   Titta L, 2010, INT J OBESITY, V34, P578, DOI 10.1038/ijo.2009.266
   Toshima S, 2000, ARTERIOSCL THROM VAS, V20, P2243, DOI 10.1161/01.ATV.20.10.2243
   Tsang C, 2018, PLANT FOOD HUM NUTR, V73, P203, DOI 10.1007/s11130-018-0673-2
   Tsuda T, 2003, J NUTR, V133, P2125, DOI 10.1093/jn/133.7.2125
   Tsuda T, 2012, MOL NUTR FOOD RES, V56, P159, DOI 10.1002/mnfr.201100526
   Unger RH, 2003, ENDOCRINOLOGY, V144, P5159, DOI 10.1210/en.2003-0870
   Valcheva-Kuzmanova Stefka V, 2006, Folia Med (Plovdiv), V48, P11
   Van Guilder GP, 2006, OBESITY, V14, P2127, DOI 10.1038/oby.2006.248
   Vasconcelos Laurylene César de Souza, 2006, Braz. Dent. J., V17, P223, DOI 10.1590/S0103-64402006000300009
   Vendrame S, 2013, J NUTR BIOCHEM, V24, P1508, DOI 10.1016/j.jnutbio.2012.12.010
   Vlachopoulos C, 2010, J AM COLL CARDIOL, V55, P1318, DOI 10.1016/j.jacc.2009.10.061
   Vroegrijk IOCM, 2011, FOOD CHEM TOXICOL, V49, P1426, DOI 10.1016/j.fct.2011.03.037
   Wallace AM, 2001, CIRCULATION, V104, P3052, DOI 10.1161/hc5001.101061
   Wang HB, 1999, J NAT PROD, V62, P294, DOI 10.1021/np980501m
   Wang SY, 2000, J AGR FOOD CHEM, V48, P140, DOI 10.1021/jf9908345
   World Health Organization, 2012, 10 FACTS DIAB
   Wu XL, 2005, J AGR FOOD CHEM, V53, P2589, DOI 10.1021/jf048068b
   Xiao D, 2017, FOOD FUNCT, V8, P3970, DOI [10.1039/c7fo00885f, 10.1039/C7FO00885F]
   Yan FJ, 2016, J NUTR BIOCHEM, V36, P68, DOI 10.1016/j.jnutbio.2016.07.004
   Yang FM, 2010, J FOOD SCI, V75, pC236, DOI 10.1111/j.1750-3841.2010.01520.x
   Yang LP, 2017, ADV NUTR, V8, P684, DOI 10.3945/an.116.014852
   Yue QY, 2018, J AGR FOOD CHEM, V66, P7190, DOI 10.1021/acs.jafc.8b01323
   Zhang YH, 2010, INFLAMM RES, V59, P723, DOI 10.1007/s00011-010-0183-7
   Zheng W, 2003, J AGR FOOD CHEM, V51, P502, DOI 10.1021/jf020728u
   Zhou FH, 2017, J NUTR SCI VITAMINOL, V63, P237, DOI 10.3177/jnsv.63.237
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI13505
NR 199
TC 76
Z9 83
U1 1
U2 27
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD DEC 4
PY 2018
VL 9
AR 1310
DI 10.3389/fphar.2018.01310
PG 19
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HC8KC
UT WOS:000452050500001
PM 30564116
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Owis, AI
   Abo-Youssef, AM
   Osman, AH
AF Owis, Asmaa I.
   Abo-youssef, Amira M.
   Osman, Ahmed H.
TI Leaves of Cordia boissieri A. DC. as a potential source of
   bioactive secondary metabolites for protection against metabolic
   syndrome-induced in rats
SO ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
LA English
DT Article
DE Cordia boissieri; metabolic syndrome; secondary metabolites
ID INSULIN-RESISTANCE; QUERCETIN; ANTIOXIDANT; FLAVONOIDS; LIVER; MODEL;
   DIET; INHIBITION; GLUCOSE; CONSTITUENTS
AB Cordia boissieri A. DC. (Boraginaceae) is traditionally used as an herbal remedy for diabetes by Hispanic women in Southwestern USA. A recent investigation showed the significant protective effect of ethyl acetate extract against metabolic syndrome (MS). However, the corresponding active principles responsible for this effect and relations between their structure and biological actions remain unclear. Thus, ethyl acetate extract was subjected to column chromatography, which yielded seven compounds identified on the basis of spectroscopic data as rutin, hesperidin, kaempferol-3O-beta-d-glucopyranoside, rosmarinic acid, beta-sitosterol-3O-beta-d-glucopyranoside, quercetin, and kaempferol. The isolated compounds (5 mg/kg/day) were tested in a fructose enriched-diet rat model using metformin as a standard drug. Blood samples were withdrawn for estimation of MS-associated biomarkers and liver samples were subjected to histopathological and immunohistochemical examination. The isolated compounds impaired most of the changes associated with MS as evidenced by improved insulin sensitivity, glucose tolerance, kidney function, lipid profiles and reduced oxidative stress and inflammation by different degrees. It is worth noting that quercetin and kaempferol showed the most potent effect. Structureactivity relationship study revealed that the presence of 2,3-double bond in ring C and ortho-hydroxylation in ring B increases the flavonoids activity while glycosylation or methylation decreased this activity.
C1 [Owis, Asmaa I.] Beni Suef Univ, Fac Pharm, Dept Pharmacognosy, Bani Suwayf, Egypt.
   [Abo-youssef, Amira M.] Beni Suef Univ, Fac Pharm, Dept Pharmacol, Bani Suwayf, Egypt.
   [Osman, Ahmed H.] Cairo Univ, Fac Vet Med, Dept Oncol, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Beni Suef University; Egyptian Knowledge
   Bank (EKB); Beni Suef University; Egyptian Knowledge Bank (EKB); Cairo
   University
RP Owis, AI (corresponding author), Beni Suef Univ, Fac Pharm, Dept Pharmacognosy, Bani Suwayf, Egypt.
EM asmaa_owis@yahoo.com
RI Ismail, Asmaa/H-2385-2016
OI Abo-Youssef, Amira/0000-0001-8419-6095
CR Al-Musayeib N, 2011, MOLECULES, V16, P10214, DOI 10.3390/molecules161210214
   Alzamendi A, 2012, PPAR RES, V2012, DOI 10.1155/2012/259093
   Anhê GF, 2012, EUR J PHARMACOL, V689, P285, DOI 10.1016/j.ejphar.2012.06.007
   Baldwin W, 2011, DIABETES, V60, P1258, DOI 10.2337/db10-0916
   Bancroft J.D., 1990, THEORY PRACTICE HIST, V3rd
   Barwick Margaret., 2004, TROPICAL SUBTROPICAL
   BEUTLER E, 1963, J LAB CLIN MED, V61, P882
   Bezerra RMN, 2001, BRAZ J MED BIOL RES, V34, P1155, DOI 10.1590/S0100-879X2001000900008
   Boustany CM, 2004, AM J PHYSIOL-REG I, V287, pR943, DOI 10.1152/ajpregu.00265.2004
   Care IoLARCo, 1985, GUID CAR US LAB AN
   Demirtas CY, 2015, EUR REV MED PHARMACO, V19, P1915
   DOMINGUE.XA, 1973, PHYTOCHEMISTRY, V12, P724, DOI 10.1016/S0031-9422(00)84473-8
   DOMINGUEZ XA, 1973, PHYTOCHEMISTRY, V12, P2996, DOI 10.1016/0031-9422(73)80523-0
   Espinola-Klein C, 2011, FRONT BIOSCI-LANDMRK, V16, P1663, DOI 10.2741/3812
   Figueiredo-Rinhel ASG, 2014, Z NATURFORSCH C, V69, P346, DOI 10.5560/ZNC.2012-0122
   Fraga CG, 2011, FREE RADICAL BIO MED, V51, P813, DOI 10.1016/j.freeradbiomed.2011.06.002
   Haffner SM, 2006, AM J CARDIOL, V97, p3A, DOI 10.1016/j.amjcard.2005.11.010
   HIRSCHHORN HH, 1981, J ETHNOPHARMACOL, V4, P129, DOI 10.1016/0378-8741(81)90032-5
   Holmes BF, 1999, J APPL PHYSIOL, V87, P1990, DOI 10.1152/jappl.1999.87.5.1990
   Horton JD, 2002, J CLIN INVEST, V109, P1125, DOI 10.1172/JCI200215593
   Hu QH, 2009, AM J PHYSIOL-RENAL, V297, pF1080, DOI 10.1152/ajprenal.90767.2008
   Ishisaka A, 2011, FREE RADICAL BIO MED, V51, P1329, DOI 10.1016/j.freeradbiomed.2011.06.017
   Jakobs S, 2006, MOL NUTR FOOD RES, V50, P52, DOI 10.1002/mnfr.200500163
   Janick Jules., 2008, The Encyclopedia of Fruit Nuts, DOI DOI 10.1016/j.tifs.2005.08.008
   Jiang WW, 2009, HEPATOB PANCREAT DIS, V8, P146
   Johnson L, 2006, PHYTOTHER RES, V20, P250, DOI 10.1002/ptr.1820
   Kawaguchi K, 1997, BIOSCI BIOTECH BIOCH, V61, P102, DOI 10.1271/bbb.61.102
   Kim JS, 2000, BIOSCI BIOTECH BIOCH, V64, P2458, DOI 10.1271/bbb.64.2458
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Koo SI, 2007, J NUTR BIOCHEM, V18, P179, DOI 10.1016/j.jnutbio.2006.12.005
   Kwon O, 2007, FASEB J, V21, P366, DOI 10.1096/fj.06-6620com
   Mabry T.J., 2012, SYSTEMATIC IDENTIFIC
   Meshkani R, 2009, CLIN BIOCHEM, V42, P1331, DOI 10.1016/j.clinbiochem.2009.05.018
   Miranda KM, 2001, NITRIC OXIDE-BIOL CH, V5, P62, DOI 10.1006/niox.2000.0319
   Molina-Salinas GM, 2007, J ETHNOPHARMACOL, V109, P435, DOI 10.1016/j.jep.2006.08.014
   Nascimento AR, 2013, OBESITY, V21, P2046, DOI 10.1002/oby.20358
   Olennikov DN, 2012, REV BRAS FARMACOGN, V22, P490, DOI 10.1590/S0102-695X2012005000010
   Owis A. I., 2016, Journal of Applied Pharmaceutical Science, V6, P83
   Owis A. I., 2014, World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS), V3, P133
   Potapovich AI, 2003, BIOCHEMISTRY-MOSCOW+, V68, P514, DOI 10.1023/A:1023947424341
   Prince PSM, 2006, J BIOCHEM MOL TOXIC, V20, P96, DOI 10.1002/jbt.20117
   Rivera L, 2008, OBESITY, V16, P2081, DOI 10.1038/oby.2008.315
   Roberts CK, 2006, METABOLISM, V55, P928, DOI 10.1016/j.metabol.2006.02.022
   Torres-Piedra M, 2010, EUR J MED CHEM, V45, P2606, DOI 10.1016/j.ejmech.2010.02.049
   UCHIYAMA M, 1978, ANAL BIOCHEM, V86, P271, DOI 10.1016/0003-2697(78)90342-1
   Wang JW, 2012, J ETHNOPHARMACOL, V142, P782, DOI 10.1016/j.jep.2012.05.063
NR 46
TC 7
Z9 9
U1 0
U2 12
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0939-5075
EI 1865-7125
J9 Z NATURFORSCH C
JI Z.Naturforsch.(C)
PD MAR
PY 2017
VL 72
IS 3-4
BP 107
EP 118
DI 10.1515/znc-2016-0073
PG 12
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA EO1LA
UT WOS:000396458800004
PM 27701140
DA 2025-06-11
ER

PT J
AU Huang, JY
   Chiang, MT
   Yet, SF
   Chau, LY
AF Huang, Jun-Yuan
   Chiang, Ming-Tsai
   Yet, Shaw-Fang
   Chau, Lee-Young
TI Myeloid Heme Oxygenase-1 Haploinsufficiency Reduces High Fat
   Diet-Induced Insulin Resistance by Affecting Adipose Macrophage
   Infiltration in Mice
SO PLOS ONE
LA English
DT Article
ID FOCAL ADHESION KINASE; CARBON-MONOXIDE; METABOLIC SYNDROME; PPAR-GAMMA;
   IN-VIVO; OBESITY; TISSUE; SENSITIVITY; ANGIOGENESIS; ACTIVATION
AB Increased adipose tissue macrophages contribute to obesity-induced metabolic syndrome. Heme oxygenase-1 (HO-1) is a stress-inducible enzyme with potent anti-inflammatory and proangiogenic activities in macrophages. However, the role of macrophage HO-1 on obesity-induced adipose inflammation and metabolic syndrome remains unclear. Here we show that high-fat diet (HFD) feeding in C57BL/6J mice induced HO-1 expression in the visceral adipose tissue, particularly the stromal vascular fraction. When the irradiated C57BL/6J mice reconstituted with wild-type or HO-1(+/-) bone marrow were fed with HFD for over 24 weeks, the HO-1(+/-) chimeras were protected from HFD-induced insulin resistance and this was associated with reduced adipose macrophage infiltration and angiogenesis, suggesting that HO-1 affects myeloid cell migration toward adipose tissue during obesity. In vivo and in vitro migration assays revealed that HO-1(+/-) macrophages exhibited an impaired migration response. Chemoattractant-induced phosphorylation of p38 and focal adhesion kinase (FAK) declined faster in HO-1(+/-) macrophages. Further experiments demonstrated that carbon monoxide and bilirubin, the byproducts derived from heme degradation by HO-1, enhanced macrophage migration by increasing phosphorylation of p38 and FAK, respectively. These data disclose a novel role of hematopoietic cell HO-1 in promoting adipose macrophage infiltration and the development of insulin resistance during obesity.
C1 [Huang, Jun-Yuan; Chau, Lee-Young] Natl Def Med Ctr, Grad Inst Life Sci, Taipei, Taiwan.
   [Huang, Jun-Yuan; Chiang, Ming-Tsai; Chau, Lee-Young] Acad Sinica, Inst Biomed Sci, Taipei, Taiwan.
   [Yet, Shaw-Fang] Natl Hlth Res Inst, Zhunan, Taiwan.
C3 National Defense Medical Center; Academia Sinica - Taiwan; National
   Health Research Institutes - Taiwan
RP Huang, JY (corresponding author), Natl Def Med Ctr, Grad Inst Life Sci, Taipei, Taiwan.
EM lyc@ibms.sinica.edu.tw
RI Chau, Lee-Young/N-7659-2018; Yet, Shaw-Fang/B-1067-2010
OI Yet, Shaw-Fang/0000-0001-9097-3962
FU National Science Council of Taiwan [NSC-97-2320-B-001-010-MY3]; National
   Research Program for Genomic Medicine at the National Science Council of
   Taiwan [NSC97-3112-B001-025]
FX This work was supported by a grant from the National Science Council of
   Taiwan (NSC-97-2320-B-001-010-MY3) (URL://web1.nsc.gov.tw). The funder
   had no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.We thank the Taiwan Mouse
   Clinic Core (NSC97-3112-B001-025) funded by the National Research
   Program for Genomic Medicine at the National Science Council of Taiwan
   for technical support.
CR Abraham NG, 2008, PHARMACOL REV, V60, P79, DOI 10.1124/pr.107.07104
   Arefieva TI, 2005, CYTOKINE, V31, P439, DOI 10.1016/j.cyto.2005.06.016
   Ashida N, 2001, J BIOL CHEM, V276, P16555, DOI 10.1074/jbc.M009068200
   Bellingan GJ, 1996, J IMMUNOL, V157, P2577
   Bilban M, 2008, J MOL MED, V86, P267, DOI 10.1007/s00109-007-0276-0
   Bråkenhielm E, 2004, CIRC RES, V94, P1579, DOI 10.1161/01.RES.0000132745.76882.70
   Brakenhielm Ebba, 2008, V456, P65, DOI 10.1007/978-1-59745-245-8_5
   Bussolati B, 2004, BLOOD, V103, P761, DOI 10.1182/blood-2003-06-1974
   Cao CZ, 2005, BLOOD, V106, P3234, DOI 10.1182/blood-2005-03-1288
   Cao Y, 2007, J CLIN INVEST, V117, P2362, DOI 10.1172/JCI32239
   Cho CH, 2007, CIRC RES, V100, pE47, DOI 10.1161/01.RES.0000259564.92792.93
   Coppack SW, 2001, P NUTR SOC, V60, P349, DOI 10.1079/PNS2001110
   Del Rio M, 1998, LIFE SCI, V63, P871, DOI 10.1016/S0024-3205(98)00344-0
   Dixit VD, 2008, J LEUKOCYTE BIOL, V84, P881, DOI 10.1189/jlb.0808471
   Dulak J, 2008, CIRCULATION, V117, P231, DOI 10.1161/CIRCULATIONAHA.107.698316
   Fujisaka S, 2009, DIABETES, V58, P2574, DOI 10.2337/db08-1475
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Hevener AL, 2007, J CLIN INVEST, V117, P1658, DOI 10.1172/JCI31561
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Johnson FK, 2006, AM J PHYSIOL-REG I, V290, pR601, DOI 10.1152/ajpregu.00308.2005
   Kanda H, 2006, J CLIN INVEST, V116, P1494, DOI 10.1172/JCI26498
   Kang K, 2008, CELL METAB, V7, P485, DOI 10.1016/j.cmet.2008.04.002
   Li M, 2008, DIABETES, V57, P1526, DOI 10.2337/db07-1764
   Lijnen HR, 2008, CARDIOVASC RES, V78, P286, DOI 10.1093/cvr/cvm007
   Lin HH, 2009, J THROMB HAEMOST, V7, P1401, DOI 10.1111/j.1538-7836.2009.03478.x
   Lin PH, 2008, BBA-MOL CELL RES, V1783, P1826, DOI 10.1016/j.bbamcr.2008.05.008
   Lumeng CN, 2007, J CLIN INVEST, V117, P175, DOI 10.1172/JCI29881
   Matsumoto H, 2006, MOL CELL BIOCHEM, V291, P21, DOI 10.1007/s11010-006-9190-y
   Mitra SK, 2005, NAT REV MOL CELL BIO, V6, P56, DOI 10.1038/nrm1549
   Morris DL, 2011, CURR OPIN CLIN NUTR, V14, P341, DOI 10.1097/MCO.0b013e328347970b
   Motterlini R, 2002, CIRC RES, V90, pE17, DOI 10.1161/hh0202.104530
   Nara N, 2007, J BIOL CHEM, V282, P30794, DOI 10.1074/jbc.M700412200
   Ndisang JF, 2009, ENDOCRINOLOGY, V150, P2098, DOI 10.1210/en.2008-0239
   Nicolai A, 2009, HYPERTENSION, V53, P508, DOI 10.1161/HYPERTENSIONAHA.108.124701
   Nomiyama T, 2007, J CLIN INVEST, V117, P2877, DOI 10.1172/JCI31986
   Odegaard JI, 2008, CELL METAB, V7, P496, DOI 10.1016/j.cmet.2008.04.003
   Odegaard JI, 2007, NATURE, V447, P1116, DOI 10.1038/nature05894
   Orozco LD, 2007, CIRC RES, V100, P1703, DOI 10.1161/CIRCRESAHA.107.151720
   Owen KA, 2007, J CELL BIOL, V179, P1275, DOI 10.1083/jcb.200708093
   Patsouris D, 2008, CELL METAB, V8, P301, DOI 10.1016/j.cmet.2008.08.015
   Pittock ST, 2005, KIDNEY INT, V68, P611, DOI 10.1111/j.1523-1755.2005.00439.x
   Poss KD, 1997, P NATL ACAD SCI USA, V94, P10919, DOI 10.1073/pnas.94.20.10919
   Rodriguez AI, 2010, ARTERIOSCL THROM VAS, V30, P98, DOI 10.1161/ATVBAHA.109.197822
   Rupnick MA, 2002, P NATL ACAD SCI USA, V99, P10730, DOI 10.1073/pnas.162349799
   Schenk S, 2008, J CLIN INVEST, V118, P2992, DOI 10.1172/JCI34260
   Song H, 2010, STEM CELLS, V28, P555, DOI 10.1002/stem.302
   Soukas A, 2000, GENE DEV, V14, P963
   Tabata M, 2009, CELL METAB, V10, P178, DOI 10.1016/j.cmet.2009.08.003
   Tschöp MH, 2012, NAT METHODS, V9, P57, DOI [10.1038/NMETH.1806, 10.1038/nmeth.1806]
   Víctor VM, 2003, INT IMMUNOPHARMACOL, V3, P97, DOI 10.1016/S1567-5769(02)00232-1
   Weis N, 2009, MOL BIOL CELL, V20, P1280, DOI 10.1091/mbc.E08-10-1005
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
NR 52
TC 29
Z9 32
U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 21
PY 2012
VL 7
IS 6
AR e38626
DI 10.1371/journal.pone.0038626
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 964KY
UT WOS:000305695100012
PM 22761690
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Rao, Y
   Lu, YT
   Li, C
   Song, QQ
   Xu, YH
   Xu, Z
   Hu, YT
   Yu, H
   Gao, L
   Gu, LQ
   Ye, JM
   Huang, ZS
AF Rao, Yong
   Lu, Yu-Ting
   Li, Chan
   Song, Qin-Qin
   Xu, Yao-Hao
   Xu, Zhao
   Hu, Yu-Tao
   Yu, Hong
   Gao, Lin
   Gu, Lian-Quan
   Ye, Ji-Ming
   Huang, Zhi-Shu
TI Bouchardatine analogue alleviates non-alcoholic hepatic fatty liver
   disease/non-alcoholic steatohepatitis in high-fat fed mice by inhibiting
   ATP synthase activity
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   CONCISE GUIDE; AMPK; PHARMACOLOGY; KINASE; PATHOGENESIS; LIPOGENESIS;
   MACROPHAGE
AB Background and Purpose Non-alcoholic hepatic fatty liver disease (NAFLD) is a manifestation of the metabolic syndrome in the liver and non-alcoholic steatohepatitis (NASH) represents its advanced stage. R17 derived from bouchardatine, shows benefits in the metabolic syndrome, but has not been tested in the liver. The present study examined the pharmacological effects of R17 in a model of NAFLD/NASH and its mode of action. Experimental Approach The effects of R17 were examined in mice fed a high-fat (HF) diet to induce the pathological characteristics of NAFLD/NASH and in cultures of HuH7 cells. We used histological and immunohistochemical techniques along with western blotting and siRNA. Generation of ROS and apoptosis were measured. Key Results Administration of R17 (20 mg center dot kg(-1), i.p. every other day) for 5 weeks reversed HF-induced hepatic triglyceride content, inflammation (inflammatory cytokines and macrophage numbers), injury (hepatocyte ballooning and apoptosis, plasma levels of alanine aminotransferase and aspartate aminotransferase), and fibrogenesis (collagen deposition and mRNA expression of fibrosis markers). In cultured cells, R17 reduced cell steatosis from both lipogenesis and fatty acid influx. The attenuated inflammation and cell injury were associated with inhibition of both endoplasmic reticulum (ER) stress and oxidative stress. Notably, R17 activated the liver kinase B1-AMP-activated protein kinase (AMPK) pathway by inhibiting activity of ATP synthase, rather than direct stimulation of AMPK. Conclusion and Implications R17 has therapeutic potential for NAFLD/NASH. Its mode of action involves the elimination of ER and oxidative stresses, possibly via activating the LKB1-AMPK axis by inhibiting the activity of ATP synthase.
C1 [Rao, Yong; Lu, Yu-Ting; Li, Chan; Song, Qin-Qin; Xu, Yao-Hao; Xu, Zhao; Hu, Yu-Tao; Yu, Hong; Gao, Lin; Gu, Lian-Quan; Huang, Zhi-Shu] Sun Yat Sen Univ, Sch Pharmaceut Sci, Inst Med Chem, Guangdong Prov Key Lab New Drug Design & Evaluat, Guangzhou 510006, Guangdong, Peoples R China.
   [Ye, Ji-Ming] RMIT Univ, Sch Hlth & Biomed Sci, Lipid Biol & Metab Dis Lab, Melbourne, Vic, Australia.
C3 Sun Yat Sen University; Royal Melbourne Institute of Technology (RMIT)
RP Rao, Y; Huang, ZS (corresponding author), Sun Yat Sen Univ, Sch Pharmaceut Sci, Inst Med Chem, Guangdong Prov Key Lab New Drug Design & Evaluat, Guangzhou 510006, Guangdong, Peoples R China.; Ye, JM (corresponding author), RMIT Univ, Sch Hlth & Biomed Sci, Bldg 202,Level 4,POB 71, Melbourne, Vic 3083, Australia.
EM raoyong0805@126.com; jiming.ye@rmil.edu.au; ceshzs@mail.sysu.edu.cn
RI Yu, Hongsheng/KYQ-5450-2024; Yutao, Hu/KBP-8586-2024; Xu,
   Yaohao/LCS-8924-2024; lu, yuting/IIS-2826-2023
OI Xu, Yao-hao/0000-0003-2406-2938; Rao, Yong/0000-0002-2559-6248
FU Bureau for Foreign Experts [SYSUPCS2014]; Local Innovative and Research
   Teams Project of Guangdong Pearl River Talents Program [2017BT01Y093];
   Guangdong Provincial Key Laboratory of Construction Foundation
   [2017B030314030]; 111 Project [B16047]; Natural Science Foundation of
   Guangdong Province [2017A030308003]; Science and Technology Program of
   Guangzhou [201704020104]; Special Fund for Science and Technology
   Development in Guangdong Province [2016A020217004]; National Natural
   Science Foundation of China [81703336, 21672265]
FX Bureau for Foreign Experts, Grant/Award Number: SYSUPCS2014; Local
   Innovative and Research Teams Project of Guangdong Pearl River Talents
   Program, Grant/Award Number: 2017BT01Y093; Guangdong Provincial Key
   Laboratory of Construction Foundation, Grant/Award Number:
   2017B030314030; 111 Project, Grant/Award Number: B16047; Natural Science
   Foundation of Guangdong Province, Grant/Award Number: 2017A030308003;
   Science and Technology Program of Guangzhou, Grant/Award Number:
   201704020104; Special Fund for Science and Technology Development in
   Guangdong Province, Grant/Award Number: 2016A020217004; National Natural
   Science Foundation of China, Grant/Award Numbers: 81703336 and 21672265
CR Alexander SPH, 2017, BRIT J PHARMACOL, V174, pS360, DOI 10.1111/bph.13883
   Alexander SPH, 2017, BRIT J PHARMACOL, V174, pS272, DOI [10.1111/bph.13877, 10.1111/bph.13882]
   Ashraf NU, 2015, FREE RADICAL RES, V49, P1405, DOI 10.3109/10715762.2015.1078461
   Chalasani NP, 2017, HEPATOLOGY, V66, p303A
   Chen YC, 2015, ACS CHEM BIOL, V10, P1570, DOI 10.1021/acschembio.5b00242
   Curtis MJ, 2018, BRIT J PHARMACOL, V175, P987, DOI 10.1111/bph.14153
   Day EA, 2017, TRENDS ENDOCRIN MET, V28, P545, DOI 10.1016/j.tem.2017.05.004
   Diehl AM, 2017, NEW ENGL J MED, V377, P2063, DOI 10.1056/NEJMra1503519
   Drew L, 2017, NATURE, V550, pS102, DOI 10.1038/550S102a
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   Harding SD, 2018, NUCLEIC ACIDS RES, V46, pD1091, DOI 10.1093/nar/gkx1121
   Hatting M, 2013, HEPATOLOGY, V57, P2189, DOI 10.1002/hep.26271
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   Jaeschke Hartmut, 2002, Hepatology, V35, P964, DOI 10.1053/jhep.2002.0350964
   Jung TW, 2018, J BIOL CHEM, V293, P3981, DOI 10.1074/jbc.RA117.000885
   Jung TW, 2015, DIABETOLOGIA, V58, P2096, DOI 10.1007/s00125-015-3663-z
   Kilkenny C, 2010, J GENE MED, V12, P561, DOI [10.1113/jphysiol.2010.192278, 10.1002/jgm.1473, 10.1111/j.1476-5381.2010.00872.x]
   Kim E, 2011, EUR J PHARMACOL, V672, P38, DOI 10.1016/j.ejphar.2011.09.172
   Kisseleva T, 2006, J GASTROEN HEPATOL, V21, pS84, DOI 10.1111/j.1440-1746.2006.04584.x
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Koyama N, 2018, J GASTROENTEROL, V53, P770, DOI 10.1007/s00535-017-1398-y
   Li J, 2018, CLIN SCI, V132, P1645, DOI 10.1042/CS20180177
   Liu TY, 2016, DIABETES, V65, P3262, DOI 10.2337/db16-0356
   McGrath JC, 2015, BRIT J PHARMACOL, V172, P3189, DOI 10.1111/bph.12955
   Musso G, 2016, NAT REV DRUG DISCOV, V15, P249, DOI 10.1038/nrd.2015.3
   Osawa Y, 2018, HEPATOL COMMUN, V2, P407, DOI 10.1002/hep4.1158
   Oyadomari S, 2004, CELL DEATH DIFFER, V11, P381, DOI 10.1038/sj.cdd.4401373
   Patton H, 2018, J HEPATOL, V68, pS839, DOI 10.1016/S0168-8278(18)31956-1
   Rao Y, 2017, BRIT J PHARMACOL, V174, P2457, DOI 10.1111/bph.13855
   Rao Y, 2015, J MED CHEM, V58, P9395, DOI 10.1021/acs.jmedchem.5b01566
   Schuppan D, 2018, J HEPATOL, V68, P238, DOI 10.1016/j.jhep.2017.11.012
   Shi CX, 2017, MOL MED REP, V16, P2767, DOI 10.3892/mmr.2017.6895
   Southan C, 2016, NUCLEIC ACIDS RES, V44, pD1054, DOI 10.1093/nar/gkv1037
   Suzuki T, 2017, CELL REP, V18, P2045, DOI 10.1016/j.celrep.2017.01.076
   Tsuchida T, 2017, NAT REV GASTRO HEPAT, V14, P397, DOI 10.1038/nrgastro.2017.38
   Turner N, 2008, DIABETES, V57, P1414, DOI 10.2337/db07-1552
   Vatner DF, 2015, P NATL ACAD SCI USA, V112, P1143, DOI 10.1073/pnas.1423952112
   Vinothkumar KR, 2014, NATURE, V515, P80, DOI 10.1038/nature13686
   Yao YF, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00171-w
   Younossi ZM, 2018, HEPATOLOGY, V68, P349, DOI 10.1002/hep.29721
   Zeng XY, 2015, BRIT J PHARMACOL, V172, P4303, DOI 10.1111/bph.13209
   Zhao XP, 2012, J CLIN INVEST, V122, P2417, DOI 10.1172/JCI61462
NR 42
TC 29
Z9 29
U1 3
U2 53
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD AUG
PY 2019
VL 176
IS 16
BP 2877
EP 2893
DI 10.1111/bph.14713
EA JUL 2019
PG 17
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IJ3PN
UT WOS:000474125100001
PM 31113010
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Cristani, M
   Speciale, A
   Saija, A
   Gangemi, S
   Minciullo, PL
   Cimino, F
AF Cristani, Mariateresa
   Speciale, Antonio
   Saija, Antonella
   Gangemi, Sebastiano
   Minciullo, Paola Lucia
   Cimino, Francesco
TI Circulating Advanced Oxidation Protein Products as Oxidative Stress
   Biomarkers and Progression Mediators in Pathological Conditions Related
   to Inflammation and Immune Dysregulation
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Advanced oxidation protein products; Biomarkers; Clinical studies;
   Oxidative stress; Myeloperoxidase; Inflammation; Immune dysregulation
ID GLYCATION END-PRODUCTS; S-NITROSYLATED PROTEINS; MULTIPLE-SCLEROSIS;
   ANTIOXIDANT STATUS; METABOLIC SYNDROME; RISK-FACTORS; CELL-DEATH;
   ALZHEIMERS-DISEASE; INSULIN-RESISTANCE; REDOX REGULATION
AB Evidence came out showing that oxidative stress has a pivotal role in development and maintenance of inflammation and aberrant immune responses. Biomarkers of oxidative stress may define the proportion of oxidative damage underlying pathological conditions, and also foresee and monitor the possible efficacy of therapeutic strategies designed to control these pathologies. New compounds, which can be used as biomarkers, have been identified, and among them advanced oxidation protein products (AOPPs), formed mainly by chlorinated oxidants resulting from activity of myeloperoxidase. Our paper is aimed to review clinical evidences concerning the valuable potential of AOPPs as biomarkers of oxidative injury in development and progression of diseases and chronic conditions related to inflammatory status and immune dysregulation. These pathologies include metabolic syndrome, obesity, immune-mediated inflammatory diseases, neurodegenerative diseases, and cancer. Due to the heterogeneity of pathologies reported to be characterized by AOPP accumulation, it is evident that AOPPs are not merely a marker of neutrophil activation, but at the same time AOPPs cannot always be disease determinants. The data reported in this review corroborate the opinion that AOPPs can be successfully used to in vitro confirm the diagnosis of inflammatory and immune-mediated diseases, but at the same time evidence is that, very likely due to the way through which AOPPs are formed as well as the effect they can contribute to induce, AOPP values cannot be clearly reflective of their involvement in the pathogenesis and in the evolution of a specific disease.
C1 [Cristani, Mariateresa; Speciale, Antonio; Saija, Antonella; Cimino, Francesco] Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, Messina, Italy.
   [Gangemi, Sebastiano; Minciullo, Paola Lucia] Univ Messina, Sch & Div Allergy & Clin Immunol, Dept Clin & Expt Med, Messina, Italy.
   [Gangemi, Sebastiano] Inst Appl Sci & Intelligent Syst ISASI, Messina Unit, Messina, Italy.
C3 University of Messina; University of Messina; Consiglio Nazionale delle
   Ricerche (CNR); Istituto di Scienze Applicate e Sistemi Intelligenti
   "Eduardo Caianiello" (ISASI-CNR)
RP Minciullo, PL (corresponding author), Univ Messina, Sch & Div Allergy & Clin Immunol, Dept Clin & Expt Med, Messina, Italy.
EM pminciullo@unime.it
RI gangemi, sebastiano/GLR-3109-2022; Cimino, Francesco/C-7036-2008;
   Speciale, Antonio/C-2846-2011
OI Speciale, Antonio/0000-0002-6135-3892; Cristani,
   Mariateresa/0000-0003-4689-9616; gangemi, sebastiano/0000-0001-7001-6532
CR Aksoy Fadlullah, 2012, Ear Nose Throat J, V91, pE32
   Aksoy Fadlullah, 2009, Kulak Burun Bogaz Ihtis Derg, V19, P279
   Albuali Waleed H, 2014, World J Clin Pediatr, V3, P6, DOI 10.5409/wjcp.v3.i1.6
   Altunoglu E, 2015, GERIATR GERONTOL INT, V15, P872, DOI 10.1111/ggi.12361
   Andersen CJ, 2016, ADV NUTR, V7, P66, DOI 10.3945/an.115.010207
   Anderstam B, 2008, CLIN CHIM ACTA, V393, P114, DOI 10.1016/j.cca.2008.03.029
   [Anonymous], 2016, MOL NEUROBIOL
   Aslani BA, 2016, LIFE SCI, V146, P163, DOI 10.1016/j.lfs.2016.01.014
   Atabek ME, 2006, EUR J PEDIATR, V165, P753, DOI 10.1007/s00431-006-0165-5
   Avinash S S, 2009, Indian J Physiol Pharmacol, V53, P370
   Babior BM, 2000, AM J MED, V109, P33, DOI 10.1016/S0002-9343(00)00481-2
   Bargnoux AS, 2009, ANN BIOL CLIN-PARIS, V67, P153, DOI 10.1684/abc.2009.0295
   Barut O, 2012, ACTA ODONTOL SCAND, V70, P303, DOI 10.3109/00016357.2011.600720
   Baskol G, 2006, CELL BIOCHEM FUNCT, V24, P307, DOI 10.1002/cbf.1257
   ben Anes A, 2014, BIOL TRACE ELEM RES, V161, P20, DOI 10.1007/s12011-014-0087-4
   Bernardes SS, 2016, TUMOR BIOL, V37, P10753, DOI 10.1007/s13277-016-4967-4
   Bordignon M, 2014, VET J, V199, P162, DOI 10.1016/j.tvjl.2013.10.028
   Bryan S, 2013, CAN J PHYSIOL PHARM, V91, P22, DOI 10.1139/cjpp-2012-0295
   Cao W., 2014, KIDNEY INT S, V4, P102
   Cao W, 2013, ANTIOXID REDOX SIGN, V18, P19, DOI 10.1089/ars.2012.4603
   Capeillère-Blandin C, 2006, NEPHROL DIAL TRANSPL, V21, P1555, DOI 10.1093/ndt/gfl007
   Castaldo SA, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/8413032
   Cervellati C, 2013, CURR ALZHEIMER RES, V10, P365, DOI 10.2174/1567205011310040003
   Cheserek Maureen J., 2015, J MED BIOCHEM, V34, P323
   Chico L, 2013, FREE RADICAL RES, V47, P569, DOI 10.3109/10715762.2013.804622
   Chiu-Braga YY, 2006, INT J CARDIOL, V109, P275, DOI 10.1016/j.ijcard.2005.04.030
   Chuah YK, 2013, INT J INFLAMM, V2013, DOI 10.1155/2013/403460
   Codoñer-Franch P, 2012, NUTR METAB CARDIOVAS, V22, P237, DOI 10.1016/j.numecd.2010.06.002
   Codoñer-Franch P, 2011, TRANSL RES, V158, P369, DOI 10.1016/j.trsl.2011.08.004
   Simao TNC, 2013, BRIT J NUTR, V110, P1885, DOI 10.1017/S0007114513001207
   Colombo G, 2015, BBA-GEN SUBJECTS, V1850, P1, DOI 10.1016/j.bbagen.2014.09.024
   Coriat R, 2012, MOL CANCER THER, V11, P2284, DOI 10.1158/1535-7163.MCT-12-0093
   Costa C, 2016, FOOD CHEM TOXICOL, V90, P30, DOI 10.1016/j.fct.2016.01.017
   Costa C, 2015, MOL MED REP, V12, P6353, DOI 10.3892/mmr.2015.4196
   Dalle-Donne I, 2006, CLIN CHEM, V52, P601, DOI 10.1373/clinchem.2005.061408
   Dhiman M, 2009, CLIN VACCINE IMMUNOL, V16, P660, DOI 10.1128/CVI.00019-09
   Di Lorenzo G, 2013, J INVEST ALLERG CLIN, V23, P101
   El-Gabalawy H, 2010, J RHEUMATOL, V37, P2, DOI 10.3899/jrheum.091461
   Farinha JB, 2015, SPORTS MED-OPEN, V1, DOI 10.1186/s40798-015-0011-2
   Gangemi S, 2015, ALLERGY, V70, P436, DOI 10.1111/all.12571
   Gangemi S, 2015, EUR J HAEMATOL, V94, P368, DOI 10.1111/ejh.12378
   Gangemi S, 2012, CANCER INVEST, V30, P20, DOI 10.3109/07357907.2011.629383
   Garcia-Garcia A, 2012, CURR MOL MED, V12, P681, DOI 10.2174/156652412800792543
   Gostner JM, 2013, REDOX REP, V18, P88, DOI 10.1179/1351000213Y.0000000044
   Griffiths HR, 2014, REDOX BIOL, V2, P430, DOI 10.1016/j.redox.2014.01.010
   Güntas G, 2015, ANN DERMATOL, V27, P178, DOI 10.5021/ad.2015.27.2.178
   Hanasand M, 2012, CLIN CHIM ACTA, V413, P901, DOI 10.1016/j.cca.2012.01.038
   Hopps E, 2013, CLIN INVEST MED, V36, pE1
   Imbesi S, 2013, EXPERT REV HEMATOL, V6, P317, DOI [10.1586/ehm.13.21, 10.1586/EHM.13.21]
   Iwao Y, 2006, DRUG METAB PHARMACOK, V21, P140, DOI 10.2133/dmpk.21.140
   Kalousová M, 2005, MUTAT RES-FUND MOL M, V579, P37, DOI 10.1016/j.mrfmmm.2005.03.024
   Karlík M, 2015, CLIN BIOCHEM, V48, P24, DOI 10.1016/j.clinbiochem.2014.09.023
   Keskin N, 2011, PEDIATR NEPHROL, V26, P1989, DOI 10.1007/s00467-011-1905-y
   Klöting N, 2014, REV ENDOCR METAB DIS, V15, P277, DOI 10.1007/s11154-014-9301-0
   Koçak H, 2007, CLIN EXP MED, V7, P173, DOI 10.1007/s10238-007-0143-x
   Korkmaz GG, 2014, CLIN LAB, V60, P599, DOI 10.7754/Clin.Lab.2013.130407
   Korkmaz GG, 2013, METABOLISM, V62, P828, DOI 10.1016/j.metabol.2013.01.002
   Kosova F, 2007, ANN SURG ONCOL, V14, P2616, DOI 10.1245/s10434-007-9425-5
   Krzystek-Korpacka M, 2008, CLIN BIOCHEM, V41, P943, DOI 10.1016/j.clinbiochem.2008.04.024
   Krzystek-Korpacka M, 2008, INFLAMM BOWEL DIS, V14, P794, DOI 10.1002/ibd.20383
   Kucukhuseyin O, 2015, ANTICANCER RES, V35, P5391
   Lemos LGT, 2015, INT IMMUNOPHARMACOL, V27, P8, DOI 10.1016/j.intimp.2015.04.037
   Liou GY, 2010, FREE RADICAL RES, V44, P479, DOI 10.3109/10715761003667554
   Liu SX, 2006, ARTERIOSCL THROM VAS, V26, P1156, DOI 10.1161/01.ATV.0000214960.85469.68
   Ljubisavljevic S, 2013, NEUROCHEM INT, V62, P988, DOI 10.1016/j.neuint.2013.02.025
   LoGerfo A, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/432626
   Lozovoy MAB, 2011, LUPUS, V20, P1250, DOI 10.1177/0961203311411350
   Ma YS, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/543760
   Marsche G, 2009, CIRC RES, V104, P750, DOI 10.1161/CIRCRESAHA.108.193169
   Marseglia L, 2015, INT J MOL SCI, V16, P378, DOI 10.3390/ijms16010378
   Matrone C, 2015, HISTOL HISTOPATHOL, V30, P125, DOI 10.14670/HH-30.125
   Matsuda M, 2013, OBES RES CLIN PRACT, V7, pE330, DOI 10.1016/j.orcp.2013.05.004
   Meaney E, 2008, CLIN EXP PHARMACOL P, V35, P895, DOI 10.1111/j.1440-1681.2008.04920.x
   Medeiros MS, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0146129
   Mehdi WA, 2013, ASIAN PAC J CANCER P, V14, P3663, DOI 10.7314/APJCP.2013.14.6.3663
   Mehdi Wesen Adel, 2015, Asian Pac J Cancer Prev, V16, P5205
   Mitchell RHB, 2014, J AM ACAD CHILD PSY, V53, P274, DOI 10.1016/j.jaac.2013.11.013
   Musolino C, 2012, CLIN BIOCHEM, V45, P1439, DOI 10.1016/j.clinbiochem.2012.07.100
   Musolino C, 2011, BIOMARKERS, V16, P718, DOI 10.3109/1354750X.2011.629059
   Musolino C, 2011, CLIN BIOCHEM, V44, P1487, DOI 10.1016/j.clinbiochem.2011.08.1149
   Nayyar Abhishek Singh, 2012, Malays J Pathol, V34, P47
   Norheim KB, 2012, FREE RADICAL RES, V46, P141, DOI 10.3109/10715762.2011.645206
   Noto C, 2015, J PSYCHIATR RES, V68, P210, DOI 10.1016/j.jpsychires.2015.07.003
   Noyan T, 2009, YONSEI MED J, V50, P677, DOI 10.3349/ymj.2009.50.5.677
   Nussbaum C, 2013, ANTIOXID REDOX SIGN, V18, P692, DOI 10.1089/ars.2012.4783
   Oliveira SR, 2014, NUTRITION, V30, P268, DOI 10.1016/j.nut.2013.08.001
   Ott C, 2014, REDOX BIOL, V2, P411, DOI 10.1016/j.redox.2013.12.016
   Oztop D, 2012, CLIN BIOCHEM, V45, P745, DOI 10.1016/j.clinbiochem.2012.03.027
   Pasquali L, 2015, CLIN BIOCHEM, V48, P19, DOI 10.1016/j.clinbiochem.2014.09.024
   Patella V, 2015, ALLERGY ASTHMA PROC, V36, pE9, DOI 10.2500/aap.2015.36.3814
   Peña-Sánchez M, 2015, CLIN BIOCHEM, V48, P1258, DOI 10.1016/j.clinbiochem.2015.06.014
   Piwowar A, 2007, DIABETES RES CLIN PR, V77, P188, DOI 10.1016/j.diabres.2006.12.007
   Rahal A, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/761264
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   Réus GZ, 2015, NEUROSCIENCE, V300, P141, DOI 10.1016/j.neuroscience.2015.05.018
   Ruggeri RM, 2016, THYROID, V26, P504, DOI 10.1089/thy.2015.0592
   Sadowska-Bartosz I, 2014, J NEUROIMMUNOL, V266, P67, DOI 10.1016/j.jneuroim.2013.11.005
   Sadowska-Bartosz I, 2013, NEUROCHEM INT, V63, P507, DOI 10.1016/j.neuint.2013.08.009
   Salahuddin P, 2014, CELL MOL BIOL LETT, V19, P407, DOI 10.2478/s11658-014-0205-5
   Samudi C, 2009, MALAYS J MED SCI, V16, P15
   Santulli P, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0072069
   Selmeci L, 2005, CLIN CHEM LAB MED, V43, P294, DOI 10.1515/CCLM.2005.050
   Selmeci L, 2006, FREE RADICAL RES, V40, P952, DOI 10.1080/10715760600818789
   Selmeci L, 2011, FREE RADICAL RES, V45, P1115, DOI 10.3109/10715762.2011.602074
   Servettaz A, 2007, ANN RHEUM DIS, V66, P1202, DOI 10.1136/ard.2006.067504
   Siciliano G, 2007, J NEUROL, V254, P575, DOI 10.1007/s00415-006-0301-1
   Siciliano G, 2005, CLIN CHEM LAB MED, V43, P745, DOI 10.1515/CCLM.2005.127
   Spatari G, 2012, INT J HYG ENVIR HEAL, V215, P389, DOI 10.1016/j.ijheh.2011.11.001
   Stanojkovic I, 2011, RESP MED, V105, pS31, DOI 10.1016/S0954-6111(11)70008-7
   Subramaniam SR, 2013, PROG NEUROBIOL, V106, P17, DOI 10.1016/j.pneurobio.2013.04.004
   Tabak O, 2011, CLIN INVEST MED, V34, pE163, DOI 10.25011/cim.v34i3.15189
   Taylor EL, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/496271
   Tesarová P, 2007, NEOPLASMA, V54, P219
   Tesarova P, 2015, NEOPLASMA, V62, P353, DOI 10.4149/neo_2015_061
   Thornalley PJ, 2014, BBA-GEN SUBJECTS, V1840, P818, DOI 10.1016/j.bbagen.2013.03.025
   Tobón-Velasco JC, 2014, CNS NEUROL DISORD-DR, V13, P1615, DOI 10.2174/1871527313666140806144831
   Turkcu UO, 2014, GENE, V536, P129, DOI 10.1016/j.gene.2013.11.055
   Unluhizarci K, 2016, EXP CLIN ENDOCR DIAB, V124, P225, DOI 10.1055/s-0035-1565192
   Venturini D, 2015, NUTR RES, V35, P759, DOI 10.1016/j.nutres.2015.06.013
   Venturini D, 2015, NUTRITION, V31, P834, DOI 10.1016/j.nut.2014.12.016
   Venturini D, 2012, OBESITY, V20, P2361, DOI 10.1038/oby.2012.130
   Veyseller B, 2010, B-ENT, V6, P105
   Vidovic B, 2014, PSYCHIAT DANUB, V26, P205
   Vlková B, 2012, ARCH ORAL BIOL, V57, P1651, DOI 10.1016/j.archoralbio.2012.09.003
   Witko-Sarsat W, 2003, KIDNEY INT, V64, P82, DOI 10.1046/j.1523-1755.2003.00044.x
   WitkoSarsat V, 1996, KIDNEY INT, V49, P1304, DOI 10.1038/ki.1996.186
   Xie F, 2014, CELL DEATH DIS, V5, DOI 10.1038/cddis.2013.542
   Xie JL, 2013, CELL SIGNAL, V25, P2185, DOI 10.1016/j.cellsig.2013.06.013
   Xie Z, 2014, GENET MOL RES, V13, P9213, DOI 10.4238/2014.November.7.8
   Yamagishi Sho-ichi, 2010, Front Biosci (Elite Ed), V2, P1184
   Yazici C, 2004, BRIT J DERMATOL, V151, P105, DOI 10.1111/j.1365-2133.2004.06003.x
   Yazici C, 2004, RHEUMATOLOGY, V43, P1235, DOI 10.1093/rheumatology/keh317
   Yazici C, 2016, ARCH DERMATOL RES, V308, P207, DOI 10.1007/s00403-016-1624-0
   Zhou QG, 2010, J CELL PHYSIOL, V225, P42, DOI 10.1002/jcp.22189
   Zurawska-Plaksej E, 2014, J ENDOCRINOL INVEST, V37, P819, DOI 10.1007/s40618-014-0111-8
NR 135
TC 61
Z9 63
U1 0
U2 19
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2016
VL 23
IS 34
BP 3862
EP 3882
DI 10.2174/0929867323666160902154748
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA EB0DN
UT WOS:000387013700001
PM 27593960
DA 2025-06-11
ER

PT J
AU Hsu, BG
   Lee, CJ
   Chen, YC
   Ho, GJ
   Lin, TY
   Lee, MC
AF Hsu, Bang-Gee
   Lee, Chung-Jen
   Chen, Yen-Cheng
   Ho, Guan-Jin
   Lin, Teng-Yi
   Lee, Ming-Che
TI Low serum-free oxygen radicals defense level is associated with
   peripheral arterial stiffness in kidney transplantation patients
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
LA English
DT Article
DE Kidney transplantation; free oxygen radicals testing; free oxygen
   radicals defense; arterial stiffness; brachial-ankle pulse wave velocity
ID METABOLIC SYNDROME; VASCULAR STIFFNESS; INSULIN-RESISTANCE; DEFINITION;
   RECIPIENTS; STRESS
AB Oxidative stress is a causative mechanism of vascular alterations resulting in arterial stiffness. The aim of this study was to evaluate the relationship between oxidative stress and arterial stiffness among kidney transplantation (KT) patients. Fasting blood samples were obtained from 70 KT patients. Arterial stiffness was measured by brachial-ankle pulse wave velocity. Oxidative stress was measured by free oxygen radicals testing (FORT) and free oxygen radicals defense (FORD). We found that diabetes (P = 0.005), hypertension (P = 0.001), metabolic syndrome (P = 0.029), age (P = 0.007), KT duration (P = 0.007), waist circumference (P = 0.039), systolic blood pressure (P < 0.001), diastolic blood pressure (P = 0.004), pulse pressure (P = 0.001), triglycerides (P = 0.049), fasting glucose (P = 0.003), insulin (P = 0.011), homeostasis model assessment of insulin resistance (HOMA-IR, P = 0.002), and FORT (P = 0.014) were all higher in the high arterial stiffness group, while HDL-C (P = 0.004) and FORD (P = 0.009) were lower. Multivariate logistic regression analysis of all significant variables showed that FORD level (OR: 0.849, 95% CI: 0.740-0.973, P = 0.019) is inversely associated with arterial stiffness. Logarithmically transformed HOMA-IR (beta = -0.280, P = 0.019) was independently associated with FORD levels in KT patients. Our study showed that KT patients with higher serum FORT level and lower FORD level had high arterial stiffness. Low serum FORD level is an independent predictor of peripheral arterial stiffness in KT patients. Among these KT patients, logarithmically transformed HOMA-IR is negatively associated with serum FORD level.
C1 [Hsu, Bang-Gee] Buddhist Tzu Chi Gen Hosp, Div Nephrol, Hualien, Taiwan.
   [Hsu, Bang-Gee; Chen, Yen-Cheng; Ho, Guan-Jin; Lee, Ming-Che] Tzu Chi Univ, Sch Med, Hualien, Taiwan.
   [Lee, Chung-Jen] Tzu Chi Univ Sci & Technol, Dept Nursing, Hualien, Taiwan.
   [Chen, Yen-Cheng; Ho, Guan-Jin; Lee, Ming-Che] Buddhist Tzu Chi Gen Hosp, Dept Surg, 707,Sect 3,Chung Yang Rd, Hualien, Taiwan.
   [Lin, Teng-Yi] Buddhist Tzu Chi Gen Hosp, Dept Lab Med, Hualien, Taiwan.
C3 Buddhist Tzu Chi General Hospital; Hualien Tzu Chi Hospital; Tzu Chi
   University; Tzu Chi University of Science & Technology; Buddhist Tzu Chi
   General Hospital; Hualien Tzu Chi Hospital; Buddhist Tzu Chi General
   Hospital; Hualien Tzu Chi Hospital
RP Lee, MC (corresponding author), Buddhist Tzu Chi Gen Hosp, Dept Surg, 707,Sect 3,Chung Yang Rd, Hualien, Taiwan.
EM mingche1229@gmail.com
RI Hsu, Bang-Gee/AAV-5287-2020; Lee, Ming-che/IQV-4552-2023; Lin,
   Tao/B-7256-2009
OI Lee, Chung Jen/0000-0003-1418-224X
FU Buddhist Tzu Chi General Hospital, Hualien, Taiwan [TCRD102-26]
FX This study was supported by a grant from the Buddhist Tzu Chi General
   Hospital, Hualien, Taiwan (TCRD102-26).
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Bachschmid MM, 2013, ANN MED, V45, P17, DOI 10.3109/07853890.2011.645498
   Cecelja M, 2012, JRSM CARDIOVASC DIS, V1, DOI 10.1258/cvd.2012.012016
   Chen LY, 2015, ATHEROSCLEROSIS, V240, P345, DOI 10.1016/j.atherosclerosis.2015.03.031
   Cianciolo G, 2014, AM J NEPHROL, V39, P418, DOI 10.1159/000362492
   Dalfino G, 2010, ATHEROSCLEROSIS, V211, P418, DOI 10.1016/j.atherosclerosis.2010.04.023
   Harvey A, 2015, J MOL CELL CARDIOL, V83, P112, DOI 10.1016/j.yjmcc.2015.04.011
   Hirai T, 2010, TRANSPL P, V42, P4061, DOI 10.1016/j.transproceed.2010.09.083
   Ho CT, 2011, J ATHEROSCLER THROMB, V18, P122, DOI 10.5551/jat.5686
   Ho GJ, 2015, CLIN EXP NEPHROL, V19, P534, DOI 10.1007/s10157-014-1010-1
   Hsu BG, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000003300
   Hsu BG, 2015, TOHOKU J EXP MED, V236, P247, DOI 10.1620/tjem.236.247
   Janic M, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/621437
   Jia GH, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00231
   Joannidès R, 2011, AM J TRANSPLANT, V11, P2414, DOI 10.1111/j.1600-6143.2011.03697.x
   Khoshdel Ali Reza, 2008, Urol J, V5, P3
   Kim HS, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0139138
   Kohn JC, 2015, FRONT GENET, V6, DOI 10.3389/fgene.2015.00112
   Le Lay S, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/908539
   Lee MC, 2014, TRANSPL P, V46, P353, DOI 10.1016/j.transproceed.2013.11.145
   Marseglia L, 2015, INT J MOL SCI, V16, P378, DOI 10.3390/ijms16010378
   Matsuzawa Y, 2015, CIRC J, V79, P685, DOI 10.1253/circj.CJ-15-0068
   Minamino T, 2007, CIRC RES, V100, P15, DOI 10.1161/01.RES.0000256837.40544.4a
   Park S, 2012, YONSEI MED J, V53, P258, DOI 10.3349/ymj.2012.53.2.258
   Pavlatou MG, 2009, METABOLISM, V58, P1657, DOI 10.1016/j.metabol.2009.05.022
   Seibert FS, 2014, CLIN TRANSPLANT, V28, P1004, DOI 10.1111/ctr.12413
   Shirwany NA, 2010, ACTA PHARMACOL SIN, V31, P1267, DOI 10.1038/aps.2010.123
   Shoskes DA, 2000, TRANSPLANT P, V32, P804, DOI 10.1016/S0041-1345(00)00991-X
   Strazhesko I, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0136676
   Strózecki P, 2011, ANN TRANSPL, V16, P30
   Sun ZJ, 2015, HYPERTENSION, V65, P252, DOI 10.1161/HYPERTENSIONAHA.114.03617
   Tomiyama H, 2010, CIRC J, V74, P24, DOI 10.1253/circj.CJ-09-0534
   Vlachopoulos C, 2015, ATHEROSCLEROSIS, V241, P507, DOI 10.1016/j.atherosclerosis.2015.05.007
   Wang CH, 2013, FEBS J, V280, P1039, DOI 10.1111/febs.12096
   Wang JH, 2014, GERIATR GERONTOL INT, V14, P640, DOI 10.1111/ggi.12151
   Zieman SJ, 2005, ARTERIOSCL THROM VAS, V25, P932, DOI 10.1161/01.ATV.0000160548.78317.29
NR 37
TC 0
Z9 0
U1 0
U2 2
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1936-2625
J9 INT J CLIN EXP PATHO
JI Int. J. Clin. Exp. Pathol.
PY 2016
VL 9
IS 10
BP 10698
EP 10706
PG 9
WC Oncology; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Pathology
GA EF5WJ
UT WOS:000390400000114
DA 2025-06-11
ER

PT J
AU Soardo, G
   Donnini, D
   Domenis, L
   Catena, C
   De Silvestri, D
   Cappello, D
   Dibenedetto, A
   Carnelutti, A
   Bonasia, V
   Pagano, C
   Sechi, LA
AF Soardo, Giorgio
   Donnini, Debora
   Domenis, Liana
   Catena, Cristiana
   De Silvestri, Daniele
   Cappello, Dario
   Dibenedetto, Alessia
   Carnelutti, Alessia
   Bonasia, Vincenzo
   Pagano, Claudio
   Sechi, Leonardo A.
TI Oxidative Stress Is Activated by Free Fatty Acids in Cultured Human
   Hepatocytes
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID NONALCOHOLIC STEATOHEPATITIS; CAROTID ATHEROSCLEROSIS; PLASMA
   ADIPONECTIN; LIVER-DISEASE; VITAMIN-E; RISK; ANTIOXIDANTS; REDOX; MODEL
AB Background: Nonalcoholic fatty liver disease (NAFLD) is strongly associated to oxidative stress, metabolic syndrome, and cardiovascular risk. Hepatocytes overloaded with fatty acids (FA) could generate substances that interfere with endothelial function, providing a potential explanation for this association. We have investigated the response of cultured human hepatoblastoma cells (Hep-G2) that were exposed to FA by measuring markers of oxidative stress and thrombosis and expression of the insulin receptor.
   Methods: Hep-G2 cells were conditioned with a mixture of FA with or without N-acetyl-L-cysteine (NAC), glutathione (GSH), or adiponectin (ADN). After 7 days, we measured intracellular GSH (iGSH), nitric oxide (NO), malondialdehyde (MDA), and tissue plasminogen inhibitor-1 (PAI-1). Real-time polymerase chain reaction (PCR) was used to determine gene expression of inducible nitric oxide synthase (iNOS) and insulin receptor (INS-R).
   Results: Exposure to FA decreased iGSH and NO levels in Hep-G2 cells and increased MDA and PAI-1 production. Gene expression of iNOS and INS-R in Hep-G2 cells was decreased by exposure to FA. Co-incubation with NAC and GSH prevented the change of iNOS mRNA levels, but not of INS-R; co-incubation with ADN restored the gene expression of INS-R, but not of i-NOS. ADN prevented also the FA-induced increase in MDA in cultured human endothelial cells.
   Conclusion: Exposure to FA activates oxidative stress and production of prothrombotic markers and decreases expression of insulin receptors in cultured human hepatocytes. These effects of FA are partially prevented by ADN and might contribute to the increased cardiovascular risk in patients with NAFLD and metabolic syndrome.
C1 [Soardo, Giorgio; Donnini, Debora; Domenis, Liana; Catena, Cristiana; De Silvestri, Daniele; Cappello, Dario; Dibenedetto, Alessia; Carnelutti, Alessia; Bonasia, Vincenzo; Sechi, Leonardo A.] Univ Udine, Liver & Hypertens Unit, Dept Pathol & Expt & Clin Med, I-33100 Udine, Italy.
   [Pagano, Claudio] Univ Padua, Endocrine Metab Lab, Dept Med & Surg Sci, Padua, Italy.
C3 University of Udine; University of Padua
RP Soardo, G (corresponding author), Univ Udine, Dept Pathol & Expt & Clin Med, Liver Unit, Piazzale SM Misericordia 1, I-33100 Udine, Italy.
EM soardo.giorgio.@aoud.sanita.fvg.it
RI Sechi, Leonardo/Y-3109-2018; Pagano, Claudio/O-1873-2013
OI PAGANO, CLAUDIO/0000-0002-4335-8411; Catena,
   Cristiana/0000-0001-5039-435X
CR Adams LA, 2005, DIABETIC MED, V22, P1129, DOI 10.1111/j.1464-5491.2005.01748.x
   Alessi MC, 2003, ARTERIOSCL THROM VAS, V23, P1262, DOI 10.1161/01.ATV.0000077401.36885.BB
   Brea A, 2005, ARTERIOSCL THROM VAS, V25, P1045, DOI 10.1161/01.ATV.0000160613.57985.18
   Calamita G, 2007, EXPERT OPIN THER TAR, V11, P1231, DOI 10.1517/14728222.11.9.1231
   Donnini D, 2000, BIOCHIMIE, V82, P1107, DOI 10.1016/S0300-9084(00)01195-0
   ECCLESTON HB, 2010, ANTIOXID REDOX  1004
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Gómez-Lechón MJ, 2007, CHEM-BIOL INTERACT, V165, P106, DOI 10.1016/j.cbi.2006.11.004
   Hoekstra R, 2002, INT J ARTIF ORGANS, V25, P182, DOI 10.1177/039139880202500304
   Hwang SJ, 1997, CIRCULATION, V96, P4219
   Kondo T, 2009, J ATHEROSCLER THROMB, V16, P532, DOI 10.5551/jat.1255
   Lavine Joel E, 2004, Clin Liver Dis, V8, P549, DOI 10.1016/j.cld.2004.04.010
   Marchesini G, 2005, CURR OPIN LIPIDOL, V16, P421, DOI 10.1097/01.mol.0000174153.53683.f2
   McCullough AJ, 2006, J CLIN GASTROENTEROL, V40, pS17
   Musso G, 2005, HEPATOLOGY, V42, P1175, DOI 10.1002/hep.20896
   Nan YM, 2009, SCAND J GASTROENTERO, V44, P1121, DOI 10.1080/00365520903114912
   Narasimhan S, 2010, CLIN BIOCHEM, V43, P815, DOI 10.1016/j.clinbiochem.2010.04.003
   Neuschwander-Tetri BA, 2005, AM J MED SCI, V330, P326, DOI 10.1097/00000441-200512000-00011
   Ong JP, 2008, J HEPATOL, V49, P608, DOI 10.1016/j.jhep.2008.06.018
   Pagano C, 2005, EUR J ENDOCRINOL, V152, P113, DOI 10.1530/eje.1.01821
   Pastore A, 2003, CLIN CHIM ACTA, V333, P19, DOI 10.1016/S0009-8981(03)00200-6
   PIEMONTE F, 2008, HEPATOLOGY, V23, P457
   Rafiq N, 2009, CLIN GASTROENTEROL H, V7, P234, DOI 10.1016/j.cgh.2008.11.005
   Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929
   Sattar N, 2004, DIABETES, V53, P2855, DOI 10.2337/diabetes.53.11.2855
   Sookoian S, 2010, ATHEROSCLEROSIS, V209, P585, DOI 10.1016/j.atherosclerosis.2009.10.011
   Targher G, 2006, DIABETIC MED, V23, P403, DOI 10.1111/j.1464-5491.2006.01817.x
   Targher G, 2004, DIABETES CARE, V27, P2498, DOI 10.2337/diacare.27.10.2498
   Targher G, 2006, CLIN ENDOCRINOL, V64, P679, DOI 10.1111/j.1365-2265.2006.02527.x
   Thuy S, 2008, J NUTR, V138, P1452, DOI 10.1093/jn/138.8.1452
   Villanova N, 2005, HEPATOLOGY, V42, P473, DOI 10.1002/hep.20781
   Yesilova Z, 2005, AM J GASTROENTEROL, V100, P850, DOI 10.1111/j.1572-0241.2005.41500.x
   Yki-Järvinen H, 2005, CURR MOL MED, V5, P287, DOI 10.2174/1566524053766031
   Zafarullah M, 2003, CELL MOL LIFE SCI, V60, P6, DOI 10.1007/s000180300001
NR 34
TC 50
Z9 54
U1 0
U2 14
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD OCT
PY 2011
VL 9
IS 5
BP 397
EP 401
DI 10.1089/met.2010.0140
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 827AN
UT WOS:000295397200010
PM 21561340
DA 2025-06-11
ER

PT J
AU Rakha, A
   Ramzan, Z
   Umar, N
   Rasheed, H
   Fatima, A
   Ahmed, Z
   Kieliszek, M
   Aadil, RM
AF Rakha, Allah
   Ramzan, Zunaira
   Umar, Nehal
   Rasheed, Hina
   Fatima, Aneela
   Ahmed, Zahoor
   Kieliszek, Marek
   Aadil, Rana Muhammad
TI The Role of Ashwagandha in Metabolic Syndrome: A Review of Traditional
   Knowledge and Recent Research Findings
SO JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
LA English
DT Review
DE Withania somnifera; Ashwagandha; withanolides; cardiovascular disorders;
   diabetes; metabolic syndrome
ID WITHANIA-SOMNIFERA ROOT; INSULIN-RESISTANCE; DIABETES-MELLITUS;
   OXIDATIVE STRESS; HYPERLIPIDEMIA; WITHANOLIDES; DYSFUNCTION; INSIGHTS
AB Metabolic syndrome (MetS) is a multifactorial disorder characterized by insulin resistance, dyslipidemia, central obesity, and hypertension, leading to an increased risk of cardiovascular diseases and type-2 diabetes. Although conventional drugs have been used to treat MetS and its associated complications, they are often linked with undesirable side effects. Consequently, there is a growing interest in herbal remedies as potential alternatives. Among these remedies is Withania somnifera, commonly known as Ashwagandha, a revered medicinal herb in traditional Chinese medicine and Ayurveda due to its numerous healthpromoting properties. Withanolides, such as withaferin-A and withanolid-D, are the primary active compounds in W. somnifera and suggested to play a pivotal role in managing MetS. Moreover, Ashwagandha exhibits hypotensive, anti-obesity, anti-diabetic, and anti-hyperlipidemic properties, influencing multiple molecular and cellular pathways associated with MetS. W. somnifera has been demonstrated its potential to considerably reduce atherosclerotic plaque formation, as well as lower levels of very low-density lipoprotein (VLDL), triglycerides (TG), and low-density lipoproteins (LDL). This comprehensive review provides valuable insights into the latest research findings on the preventive potential of W. somnifera against MetS. Furthermore, recent studies on Ashwagandha highlight the need for additional clinical trials to evaluate its optimal dosage, safety profile, efficacy, and precise mechanisms of action.
C1 [Rakha, Allah; Ramzan, Zunaira; Umar, Nehal; Rasheed, Hina; Aadil, Rana Muhammad] Univ Agr Faisalabad, Natl Inst Food Sci & Technol, Faisalabad 38000, Pakistan.
   [Fatima, Aneela] Pakistan Council Sci & Ind Res, Peshawar, Pakistan.
   [Ahmed, Zahoor] Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Jiangsu, Peoples R China.
   [Kieliszek, Marek] Warsaw Univ Life Sci SGGW, Inst Food Sci, Dept Food Biotechnol & Microbiol, PL-02776 Warsaw, Poland.
C3 University of Agriculture Faisalabad; PCSIR Laboratories Complex;
   Jiangsu University; Warsaw University of Life Sciences
RP Aadil, RM (corresponding author), Univ Agr Faisalabad, Natl Inst Food Sci & Technol, Faisalabad 38000, Pakistan.
EM muhammad.aadil@uaf.edu.pk
RI Aadil, Rana Muhammad/GRY-2404-2022; Ahmad, Zahoor/AAB-3522-2021;
   Kieliszek, Marek/V-4421-2018
OI Kieliszek, Marek/0000-0002-5836-4865
CR Abdelwahed MT, 2023, REV ANAL CHEM, V42, DOI 10.1515/revac-2022-0055
   Acharya P, 2020, J AGR FOOD RES, V2, DOI 10.1016/j.jafr.2020.100035
   Adi BSABS, 2019, International Journal of Indigenous Herbs and Drugs, P1
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Andallu B., 2000, Indian Journal of Experimental Biology, V38, P607
   Anwar R, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/5720372
   Anwer T, 2008, BASIC CLIN PHARMACOL, V102, P498, DOI 10.1111/j.1742-7843.2008.00223.x
   Anwer T, 2017, TROP J PHARM RES, V16, P119, DOI 10.4314/tjpr.v16i1.15
   Arafa R, 2021, Journal of Researvh in the Fields of Specific Education, V7, P1239
   Arhire LL, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00524
   Asala Titilayo Mercy, 2022, International Journal of Veterinary Science, V11, P289, DOI 10.47278/journal.ijvs/2021.112
   Bharti V. K., 2016, Nutraceuticals, P717, DOI [DOI 10.1016/B978-0-12-802147-7.00052-8, 10.1016/b978-0-12-802147-7.00052-8]
   Bhasin S., 2019, J. Pharmacogn. Phytochem, V8, P3906
   Blüher M, 2019, NAT REV ENDOCRINOL, V15, P288, DOI 10.1038/s41574-019-0176-8
   Castro-Barquero S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12102983
   Chaudhuri D, 2012, Asian Journal of Pharmaceutical and Clinical Research, V5, P193
   Chauhan S, 2022, HEALTH SCI REP-US, V5, DOI 10.1002/hsr2.741
   Costa FF, 2020, DIAB MET SYND CLIN R, V14, P809, DOI 10.1016/j.dsx.2020.06.016
   Ekor M, 2014, FRONT PHARMACOL, V4, DOI 10.3389/fphar.2013.00177
   El-Motaily Noha M., 2022, International Journal of Veterinary Science, V11, P467, DOI 10.47278/journal.ijvs/2022.137
   Feng JN, 2020, BIOL TRACE ELEM RES, V196, P74, DOI 10.1007/s12011-019-01922-0
   Galiè N, 2019, EUR RESPIR J, V53, DOI 10.1183/13993003.02148-2018
   Gaurav H, 2023, MOLECULES, V28, DOI 10.3390/molecules28031208
   Gopinath D., 2021, Indian Journal of Animal Research, V1, P9
   Gupta G. L., 2007, Pharmacognosy Reviews, V1, P129
   Haseeb Anwar Haseeb Anwar, 2015, Pakistan Journal of Life and Social Sciences, V13, P31
   Hashem Heba A., 2023, Journal of Advanced Veterinary Research, V13, P508
   Hassan F, 2022, PAK VET J, V42, P141, DOI 10.29261/pakvetj/2022.011
   He FJ, 2020, J AM COLL CARDIOL, V75, P632, DOI 10.1016/j.jacc.2019.11.055
   Ibrahim MS, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-027326
   Iqbal Z, 2022, Pakistan Veterinary Journal, P42
   Jaiswal D, 2009, INDIAN J CLIN BIOCHE, V24, P88, DOI 10.1007/s12291-009-0015-0
   Jash K, 2020, DRUG DEVELOP RES, V81, P144, DOI 10.1002/ddr.21579
   Jha SK, Journal of Applied and Natural Science, V12, P454
   Jonathan G, 2015, PHYTOCHEMISTRY, V116, P283, DOI 10.1016/j.phytochem.2015.02.029
   Kalra R, 2017, PHYTOCHEM REV, V16, P953, DOI 10.1007/s11101-017-9504-6
   Kaur G, 2015, PHARM BIOL, V53, P147, DOI 10.3109/13880209.2014.912240
   Kaur T, 2017, J NEUROINFLAMM, V14, DOI 10.1186/s12974-017-0975-6
   Kempegowda P. K., 2018, BIOMED RES, V29, P3192, DOI DOI 10.4066/BIOMEDICALRESEARCH.29-18-922
   Khabiya R, 2023, Acta Ecologica Sinica
   Khalil MI, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/624159
   Kherde SD, 2020, INDIAN J TRADIT KNOW, V19, P486
   Krutika J., 2016, International Journal of Pharmaceutical and Biological Archives, V7, P1
   Ksenofontova A. A., 2022, International Journal of Veterinary Science, V11, P420, DOI 10.47278/journal.ijvs/2022.153
   Kumar R., 2020, World J. Pharm. Pharm. Sci, V9, P838, DOI DOI 10.20959/WJPPS202010-17336
   Kumar V., 2017, Science of Ashwagandha: Preventive and Therapeutic Potentials, DOI [10.1007/978-3-319-59192-62, DOI 10.1007/978-3-319-59192-62]
   Kumari S., 2016, International Journal of Home Science, V2, P68
   Kushwaha S, 2012, STUD ETHNO-MED, V6, P111, DOI 10.1080/09735070.2012.11886427
   Kylliang A. K., 2019, Journal of Ayurveda and Integrated Medical Sciences, V4, P79
   Laylani LASS., 2018, Iraqi J Sci, V59, P267
   Lee BS, 2021, PHARMACEUTICALS-BASE, V14, DOI 10.3390/ph14101017
   Lee DH, 2021, PHYTOMEDICINE, V82, DOI 10.1016/j.phymed.2020.153457
   Lee DH, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020431
   Lee SR, 2022, J GINSENG RES, V46, P357, DOI 10.1016/j.jgr.2021.09.004
   Li M, 2020, PHARMACOL THERAPEUT, V212, DOI 10.1016/j.pharmthera.2020.107539
   Lima JEBF, 2022, MUTAT RES-GEN TOX EN, V874, DOI 10.1016/j.mrgentox.2021.503437
   Makki Kassem, 2013, ISRN Inflamm, V2013, P139239, DOI 10.1155/2013/139239
   Manchanda S, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1652-0
   Mandlik DS, 2021, J DIET SUPPL, V18, P183, DOI 10.1080/19390211.2020.1741484
   Masoud S., 2019, Int. J. Pharmacogn., V6, P133
   Miao JY, 2020, ADV EXP MED BIOL, V1207, P237, DOI 10.1007/978-981-15-4272-5_18
   Mikulska P, 2023, PHARMACEUTICS, V15, DOI 10.3390/pharmaceutics15041057
   Mubashir Anam, 2022, International Journal of Agriculture and Biosciences, V11, P70, DOI 10.47278/journal.ijab/2022.010
   Mukherjee PK, 2021, J ETHNOPHARMACOL, V264, DOI 10.1016/j.jep.2020.113157
   Mukherjee PK, 2017, J ETHNOPHARMACOL, V197, P10, DOI 10.1016/j.jep.2016.09.024
   Nayak S., 2015, Ayushdhara, V2, P413
   Nilsson PM, 2019, EUR J PREV CARDIOL, V26, P33, DOI 10.1177/2047487319886404
   Noshahr ZS, 2015, REP BIOCHEM MOL BIOL, V3, P62
   Patel S, 2019, International Journal of Pharmacognosy, V6, P2394
   Paul S, 2021, BIOMED PHARMACOTHER, V143, DOI 10.1016/j.biopha.2021.112175
   Pedhavi S., 2017, ADV AGR RES TECHNOL, V1, P57
   Ram H, 2021, BIOINTERFACE RES APP, V11, P8141, DOI 10.33263/BRIAC111.81418155
   Rasheed H, 2022, APPL SCI-BASEL, V12, DOI 10.3390/app12063170
   Raut Ashwinikumar A, 2012, J Ayurveda Integr Med, V3, P111, DOI 10.4103/0975-9476.100168
   Rizvi MK, 2022, MOLECULES, V27, DOI 10.3390/molecules27217184
   Rohit Jain Rohit Jain, 2012, Journal of Medicinal Plants Research, V6, P5388
   Rozanska O, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21030841
   Sarangi A., 2013, J. Cell Tissue Res, V13, P3597
   Shabbir MA, 2021, TRENDS FOOD SCI TECH, V111, P483, DOI 10.1016/j.tifs.2021.03.010
   Shah RA, 2017, INT J PHARM SCI RES, V8, P120, DOI 10.13040/IJPSR.0975-8232.8(1).120-25
   Sharma G, 2021, Journal of Ayurveda, V15, P155
   Sharma S, 2018, IJPBS, V8, P639
   Shin NR, 2017, J ETHNOPHARMACOL, V209, P108, DOI 10.1016/j.jep.2017.07.033
   Singh N, 2011, AFR J TRADIT COMPLEM, V8, P208, DOI 10.4314/ajtcam.v8i5S.9
   Singh V., 2017, CANADIAN J CLIN NUTR, P34, DOI [10.14206/canad.j.clin.nutr.2017.02.04, DOI 10.14206/CANAD.J.CLIN.NUTR.2017.02.04]
   Srivastava M., 2018, Asian J Pharm Pharmacol, V4, P123, DOI [10.31024/ajpp.2018.4.2.5, DOI 10.31024/AJPP.2018.4.2.5]
   Tangvarasittichai S, 2015, WORLD J DIABETES, V6, P456, DOI 10.4239/wjd.v6.i3.456
   Tanwar A., 2022, Asian Journal of Pharmaceutical Research and Development, V10, P47, DOI [10.22270/ajprd.v10i4.1162, DOI 10.22270/AJPRD.V10I4.1162]
   Tekula S, 2018, BIOMED PHARMACOTHER, V106, P1428, DOI 10.1016/j.biopha.2018.07.090
   Thakur AK, 2015, CURR TRADIT MED, V1, P51, DOI 10.2174/2215083801999150527115205
   Tharakan A, 2021, J CLIN MED, V10, DOI 10.3390/jcm10163644
   Tomar V, 2019, J CHROMATOGR B, V1124, P154, DOI 10.1016/j.jchromb.2019.06.009
   Tomic D, 2022, NAT REV ENDOCRINOL, V18, P525, DOI 10.1038/s41574-022-00690-7
   Trautwein EA, 2020, NUTRIENTS, V12, DOI 10.3390/nu12092671
   Tsao CW, 2022, CIRCULATION, V145, pE153, DOI 10.1161/CIR.0000000000001052
   Tumminia A, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19113306
   Udayakumar R, 2009, INT J MOL SCI, V10, P2367, DOI 10.3390/ijms10052367
   Uthirapathy S, 2021, ARO, V9, DOI 10.14500/aro.10844
   Wadhwa R, 2017, Science of Ashwagandha: Preventive and Therapeutic Potentials, P283
   Wang HH, 2020, PEDIATR GASTROENTERO, V23, P189
   Wang Yue, 2021, Zhongguo Zhong Yao Za Zhi, V46, P5159, DOI 10.19540/j.cnki.cjcmm.20210725.101
   Wani DAA, 2021, International Journal of Unani and Integrative Medicine, V5, P11
   Zhou HP, 2020, J INFLAMM RES, V13, P1, DOI 10.2147/JIR.S229691
NR 103
TC 6
Z9 6
U1 2
U2 9
PU Asia Pacific Acad Science Pte. Ltd.
PI SINGAPORE
PA 16 COLLYER QUAY #12-01 INCOME AT RAFFLES SINGAPORE, SINGAPORE, SINGAPORE
SN 0393-974X
EI 1724-6083
J9 J BIOL REG HOMEOS AG
JI J. Biol. Regul. Homeost. Agents
PD SEP
PY 2023
VL 37
IS 10
BP 5091
EP 5103
DI 10.23812/j.biol.regul.homeost.agents.20233710.494
PG 13
WC Endocrinology & Metabolism; Immunology; Medicine, Research &
   Experimental; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Research & Experimental
   Medicine; Physiology
GA X4BK6
UT WOS:001097921100001
DA 2025-06-11
ER

PT J
AU Xu, J
   Peng, Y
   Zeng, Y
   Hua, YQ
   Xu, XL
AF Xu, Jin
   Peng, Yi
   Zeng, Yi
   Hua, Yi-qiao
   Xu, Xiao-le
TI 2, 3, 4′, 5-tetrahydroxystilbene-2-0-β-d Glycoside Attenuates Age- and
   Diet-Associated Non-Alcoholic Steatohepatitis and Atherosclerosis in LDL
   Receptor Knockout Mice and Its Possible Mechanisms
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE nonalcoholic steatohepatitis; atherosclerosis; metabolic syndrome
ID TETRAHYDROXYSTILBENE GLUCOSIDE; HEPATIC STEATOSIS; CHOLESTEROL;
   PATHOGENESIS; METHIONINE; MODEL
AB The compound, 2,3,5,4 '-tetrahydroxystilbene-2-O-beta-d-glucoside (TSG), a primary bioactive polyphenolic component of Polygonum multiflorum exerts numerous pharmacological activities. However, its protective effect against non-alcoholic steatohepatitis (NASH), in the context of metabolic syndrome, remains poorly understood. The aim of the present study is to evaluate the effects of TSG treatment on middle-aged (12-mo-old) male LDLr-/- mice, which were fed a high fat diet for 12 weeks to induce metabolic syndrome and NASH. At the end of the experiment, the blood samples of mice were collected for determination of metabolic parameters. Liver and aorta tissues were collected for analysis, such as histology, immunofluorescence, hepatic lipid content, real-time PCR, and western blot. Our data show that TSG treatment improved the different aspects of NASH (steatosis, inflammation, and fibrosis) and atherosclerosis, as well as some of the metabolic basal characteristics. These modulatory effects of TSG are mediated, at least in part, through regulating key regulators of lipid metabolism (SREBP1c, PPAR alpha and their target genes, ABCG5 and CYP7A1), inflammation (CD68, TNF-alpha, IL-6 and ICAM), fibrosis (alpha-SMA and TNF beta) and oxidative stress (NADPH-oxidase 2/4, CYP2E1 and antioxidant enzymes). These results suggest that TSG may be a promising candidate for preventing and treating the progression of NASH.
C1 [Xu, Jin; Peng, Yi; Zeng, Yi; Hua, Yi-qiao; Xu, Xiao-le] Nantong Univ, Pharm Coll, Dept Pharmacol, Nantong 226001, Peoples R China.
C3 Nantong University
RP Xu, XL (corresponding author), Nantong Univ, Pharm Coll, Dept Pharmacol, Nantong 226001, Peoples R China.
EM xjntu2603@126.com; bennym@163.com; yizeng668@aliyun.com;
   hyq971112@163.com; xiaolexu@ntu.edu.cn
FU National Science Foundation of China [81770446]; Six Talents Peak
   Project of Jiangsu Province [SWYY-022]; Nantong University Cooperative
   Innovation Program of Small Molecular Compound RD [NTU2016-1]
FX The research was supported by the National Science Foundation of China
   (Grant No. 81770446), the Six Talents Peak Project of Jiangsu Province
   (No. SWYY-022) and the Nantong University Cooperative Innovation Program
   of Small Molecular Compound R&D (NTU2016-1).
CR [Anonymous], ADV HEPATOL
   Buzzetti E, 2016, METABOLISM, V65, P1038, DOI 10.1016/j.metabol.2015.12.012
   Bzowej NH, 2018, CURR OPIN ORGAN TRAN, V23, P169, DOI 10.1097/MOT.0000000000000502
   Chen XF, 2017, PHARMACOLOGY, V99, P153, DOI 10.1159/000452672
   Chen XM, 2018, CAN J PHYSIOL PHARM, V96, P8, DOI 10.1139/cjpp-2017-0474
   Ferré P, 2010, DIABETES OBES METAB, V12, P83, DOI 10.1111/j.1463-1326.2010.01275.x
   Finck BN, 2018, DIABETES, V67, P2485, DOI 10.2337/dbi18-0024
   Gupte AA, 2014, ENDOCRINOLOGY, V155, P4697, DOI 10.1210/en.2014-1430
   Gupte AA, 2010, HEPATOLOGY, V52, P2001, DOI 10.1002/hep.23941
   Han MN, 2018, EXP THER MED, V16, P1087, DOI 10.3892/etm.2018.6300
   Hellerstein M, 2014, CURR OPIN LIPIDOL, V25, P40, DOI 10.1097/MOL.0000000000000050
   Ikejima K, 2005, HEPATOL RES, V33, P151, DOI 10.1016/j.hepres.2005.09.024
   Li J, 2017, FOOD FUNCT, V8, P2886, DOI 10.1039/c7fo00290d
   Li XF, 2017, ONCOTARGET, V8, P100801, DOI 10.18632/oncotarget.19007
   Li Y, 2011, CELL METAB, V13, P376, DOI 10.1016/j.cmet.2011.03.009
   Liu TT, 2017, ATHEROSCLEROSIS, V262, P39, DOI 10.1016/j.atherosclerosis.2017.05.003
   Meng GL, 2018, BRIT J PHARMACOL, V175, P1126, DOI 10.1111/bph.13861
   Musso G, 2018, GASTROENTEROLOGY, V155, P282, DOI 10.1053/j.gastro.2018.06.031
   Nagappan A, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19092601
   Ning ZC, 2018, GERONTOLOGY, V64, P457, DOI 10.1159/000487360
   Pandak WM, 2001, AM J PHYSIOL-GASTR L, V281, pG878, DOI 10.1152/ajpgi.2001.281.4.G878
   Rinella ME, 2004, J HEPATOL, V40, P47, DOI 10.1016/j.jhep.2003.09.020
   Sayiner M, 2018, THER ADV GASTROENTER, V11, DOI 10.1177/1756284818811508
   Sodhi K, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-00306-5
   Takaki A, 2013, INT J MOL SCI, V14, P20704, DOI 10.3390/ijms141020704
   Tang K, 2018, EUR J PHARMACOL, V830, P76, DOI 10.1016/j.ejphar.2018.04.026
   Wang H, 2017, CNS NEUROSCI THER, V23, P627, DOI 10.1111/cns.12708
   Wu JJ, 2017, EUR J PHARMACOL, V811, P21, DOI 10.1016/j.ejphar.2017.05.037
   Yang LF, 2017, TOXICOLOGY, V389, P74, DOI 10.1016/j.tox.2017.07.010
   Yang ZR, 2016, BMC PHARMACOL TOXICO, V17, DOI 10.1186/s40360-016-0059-8
   Yao WJ, 2016, BIOMED PHARMACOTHER, V83, P1132, DOI 10.1016/j.biopha.2016.08.032
   Yao WJ, 2016, CAN J PHYSIOL PHARM, V94, P155, DOI 10.1139/cjpp-2015-0160
   Yao WJ, 2013, BIOMED PHARMACOTHER, V67, P140, DOI 10.1016/j.biopha.2012.10.007
   Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431
   Yu XH, 2014, CLIN CHIM ACTA, V428, P82, DOI 10.1016/j.cca.2013.11.010
NR 35
TC 26
Z9 29
U1 1
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR 1
PY 2019
VL 20
IS 7
AR 1617
DI 10.3390/ijms20071617
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HU0TP
UT WOS:000464984500008
PM 30939745
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU He, Q
   Wang, Z
   Liu, G
   Daneshgari, F
   MacLennan, GT
   Gupta, S
AF He, Q.
   Wang, Z.
   Liu, G.
   Daneshgari, F.
   MacLennan, G. T.
   Gupta, S.
TI Metabolic syndrome, inflammation and lower urinary tract symptoms:
   possible translational links
SO PROSTATE CANCER AND PROSTATIC DISEASES
LA English
DT Review
ID BENIGN PROSTATIC HYPERPLASIA; C-REACTIVE PROTEIN; OVERACTIVE BLADDER;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; VAGINAL TRAUMA; INTERLEUKIN-8;
   OBESITY; INCONTINENCE; PREVALENCE
AB BACKGROUND: Epidemiological data suggest that lower urinary tract symptoms (LUTSs) may be associated with metabolic syndrome (MetS). Inflammation has been proposed as a candidate mechanism at the crossroad between these two clinical entities. The aim of this review article is to evaluate the role of MetS-induced inflammation in the pathogenesis and progression of LUTS.
   METHODS: A systematic review was conducted using the keywords 'metabolic syndrome and lower urinary tract symptoms' within the title search engines including PubMed, Web of Science and the Cochrane Library for relevant research work published between 2000 and January 2015. The obtained literature was reviewed by the primary author (QH) and was assessed for eligibility and standard level of evidence.
   RESULTS: Total of 52 articles met the eligibility criteria. On the basis of database search during the past 15 years and our systematic review of prospective and retrospective cohorts, case-control trials, observational studies and animal data identified a possible link between MetS-induced inflammation and LUTS including BPH, bladder outlet obstruction, overactive bladder, urinary incontinence and other possible urinary tract abnormalities.
   CONCLUSIONS: There is convincing evidence to suggest that MetS and inflammation could be important contributors to LUTS in men, particularly in the development of BPH. However, the role of MetS-induced inflammation remains unclear in overactive bladder, urinary incontinence and etiology of LUTS progression.
C1 [He, Q.; Gupta, S.] Case Western Reserve Univ, Dept Urol, 10900 Euclid Ave, Cleveland, OH 44106 USA.
   [He, Q.; MacLennan, G. T.; Gupta, S.] Univ Hosp, Case Med Ctr, 10900 Euclid Ave, Cleveland, OH 44106 USA.
   [He, Q.; Wang, Z.] Lanzhou Univ, Dept Urol, Key Lab Dis Urol Syst, Gansu Nephrourol Clin Ctr,Hosp 2, Lanzhou 730000, Gansu, Peoples R China.
   [Liu, G.; Daneshgari, F.] Case Western Reserve Univ, Dept Surg, MetroHealth Med Ctr, Cleveland, OH 44106 USA.
   [MacLennan, G. T.] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA.
C3 University System of Ohio; Case Western Reserve University; University
   System of Ohio; Case Western Reserve University; University Hospitals of
   Cleveland; Lanzhou University; University System of Ohio; Case Western
   Reserve University; MetroHealth System; University System of Ohio; Case
   Western Reserve University
RP Gupta, S (corresponding author), Case Western Reserve Univ, Dept Urol, 10900 Euclid Ave, Cleveland, OH 44106 USA.; Gupta, S (corresponding author), Univ Hosp, Case Med Ctr, 10900 Euclid Ave, Cleveland, OH 44106 USA.
EM sanjay.gupta@case.edu
RI Liu, Guiming/AAM-2688-2020
OI MacLennan, Gregory T./0000-0003-0089-449X; Gupta,
   Sanjay/0000-0002-9492-3249
FU United States Public Health Services [P20DK090871]; China Scholarship
   Council [201306180078]
FX We apologize to those investigators whose original work could not be
   cited owing to the space limitation. The original work cited in this
   review was supported by grants from United States Public Health Services
   P20DK090871 and 201306180078 from China Scholarship Council.
CR Abrams P, 2002, NEUROUROL URODYNAM, V21, P167, DOI 10.1002/nau.10052
   Adorini L, 2010, ANN NY ACAD SCI, V1193, P146, DOI 10.1111/j.1749-6632.2009.05299.x
   Agilli M, 2015, INT UROL NEPHROL, V47, P317, DOI 10.1007/s11255-014-0879-7
   Bhide AA, 2013, INT UROGYNECOL J, V24, P1065, DOI 10.1007/s00192-012-2027-1
   Bhindi B, 2014, UROLOGY, V83, P81, DOI 10.1016/j.urology.2013.07.039
   Biernacka A, 2011, GROWTH FACTORS, V29, P196, DOI 10.3109/08977194.2011.595714
   Bunn F, 2015, INT J CLIN PRACT, V69, P199, DOI 10.1111/ijcp.12518
   Cantiello F, 2013, UROLOGY, V81, P1018, DOI 10.1016/j.urology.2013.01.053
   Chen HY, 2013, EUR J OBSTET GYN R B, V171, P171, DOI 10.1016/j.ejogrb.2013.08.034
   Chen HY, 2012, EUR J OBSTET GYN R B, V163, P224, DOI 10.1016/j.ejogrb.2012.04.012
   Chung SD, 2011, NEUROUROL URODYNAM, V30, P417, DOI 10.1002/nau.20938
   Colodner R, 2006, EUR J CLIN MICROBIOL, V25, P238, DOI 10.1007/s10096-006-0132-0
   Dallosso HM, 2003, BJU INT, V92, P69, DOI 10.1046/j.1464-410X.2003.04271.x
   De Nunzio C, 2014, UROLOGY, V84, P1181, DOI 10.1016/j.urology.2014.07.018
   De Nunzio C, 2011, EUR UROL, V60, P106, DOI 10.1016/j.eururo.2011.03.055
   Delongchamps NB, 2008, J UROLOGY, V179, P1736, DOI 10.1016/j.juro.2008.01.034
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Devaraj S, 2009, CURR OPIN LIPIDOL, V20, P182, DOI 10.1097/MOL.0b013e32832ac03e
   Donnell RF, 2011, CURR OPIN UROL, V21, P22, DOI 10.1097/MOU.0b013e32834100dd
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Eynard AR, 2013, NUTRITION, V29, P930, DOI 10.1016/j.nut.2012.12.014
   Fagerberg B, 2008, SCAND J CLIN LAB INV, V68, P534, DOI 10.1080/00365510701870898
   Fibbi B, 2010, INT J ANDROL, V33, P475, DOI 10.1111/j.1365-2605.2009.00972.x
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gacci M, 2015, BJU INT, V115, P24, DOI 10.1111/bju.12728
   Gharaee-Kermani M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0049278
   Giri D, 2001, AM J PATHOL, V159, P139, DOI 10.1016/S0002-9440(10)61681-1
   Golden SH, 2009, J CLIN ENDOCR METAB, V94, P1853, DOI 10.1210/jc.2008-2291
   Greenfield JR, 2006, CURR DIABETES REV, V2, P195, DOI 10.2174/157339906776818532
   Grundy SM, 2004, J CLIN ENDOCR METAB, V89, P2595, DOI 10.1210/jc.2004-0372
   He QQ, 2014, AGING MALE, V17, P223, DOI 10.3109/13685538.2014.967671
   Heilbronn LK, 2008, CURR PHARM DESIGN, V14, P1225, DOI 10.2174/138161208784246153
   Hochreiter WW, 2000, UROLOGY, V56, P1025, DOI 10.1016/S0090-4295(00)00844-X
   Hsiao SM, 2012, INT UROGYNECOL J, V23, P935, DOI 10.1007/s00192-012-1715-1
   Jou YC, 2013, UROLOGY, V82, P295, DOI 10.1016/j.urology.2013.04.011
   Juan YS, 2012, BJU INT, V110, pE236, DOI 10.1111/j.1464-410X.2012.11258.x
   Kalyani Rita R, 2007, Curr Opin Endocrinol Diabetes Obes, V14, P226, DOI 10.1097/MED.0b013e32814db856
   Kasturi Sanjay, 2006, Curr Urol Rep, V7, P288, DOI 10.1007/s11934-996-0008-y
   Keddis MT, 2013, CURR OPIN NEPHROL HY, V22, P390, DOI 10.1097/MNH.0b013e32836214b9
   King D, 2011, LANCET, V378, P743, DOI 10.1016/S0140-6736(11)61261-0
   Krieger JN, 2008, INT J ANTIMICROB AG, V31, pS85, DOI 10.1016/j.ijantimicag.2007.08.028
   Kuo HC, 2013, TZU CHI MED J, V25, P13, DOI 10.1016/j.tcmj.2012.10.005
   Kwon YK, 2010, KOREAN J UROL, V51, P266, DOI 10.4111/kju.2010.51.4.266
   Lee S, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0116827
   Lenis AT, 2013, J UROLOGY, V189, P1588, DOI 10.1016/j.juro.2012.09.096
   Link CL, 2011, J UROLOGY, V185, P955, DOI 10.1016/j.juro.2010.10.048
   Liu LR, 2009, UROLOGY, V74, P340, DOI 10.1016/j.urology.2009.02.064
   Liu YH, 2011, NAT REV NEPHROL, V7, P684, DOI 10.1038/nrneph.2011.149
   Lotti F, 2015, HUM REPROD, V30, P590, DOI 10.1093/humrep/deu347
   Lotti F, 2014, ASIAN J ANDROL, V16, P295, DOI 10.4103/1008-682X.122341
   Lotti F, 2013, J REPROD IMMUNOL, V100, P54, DOI 10.1016/j.jri.2013.02.004
   McConnell JD, 2003, NEW ENGL J MED, V349, P2387, DOI 10.1056/NEJMoa030656
   Mishra VC, 2007, BJU INT, V100, P327, DOI 10.1111/j.1464-410X.2007.06910.x
   Morelli A, 2014, MOL CELL ENDOCRINOL, V382, P107, DOI 10.1016/j.mce.2013.09.017
   Moul S, 2010, CURR OPIN UROL, V20, P7, DOI 10.1097/MOU.0b013e3283336f3f
   Nickel J C, 1994, Can J Urol, V1, P1
   Nickel JC, 2008, EUR UROL, V54, P1379, DOI 10.1016/j.eururo.2007.11.026
   Nickel JC, 1999, BJU INT, V84, P976
   Ozden C, 2007, EUR UROL, V51, P199, DOI 10.1016/j.eururo.2006.05.040
   Parsons JK, 2013, J UROLOGY, V189, pS102, DOI 10.1016/j.juro.2012.11.029
   Penna G, 2007, EUR UROL, V51, P524, DOI 10.1016/j.eururo.2006.07.016
   Penna G, 2009, PROSTATE, V69, P480, DOI 10.1002/pros.20896
   Penna G, 2009, J IMMUNOL, V182, P4056, DOI 10.4049/jimmunol.0801875
   Powell K, 2007, NATURE, V447, P525, DOI 10.1038/447525a
   Robert G, 2009, PROSTATE, V69, P1774, DOI 10.1002/pros.21027
   Rodriguez-Nieves JA, 2013, NAT REV UROL, V10, P546, DOI 10.1038/nrurol.2013.149
   Shankar E, 2012, PROSTATE, V72, P233, DOI 10.1002/pros.21425
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Steigedal M, 2014, J IMMUNOL, V193, P6081, DOI 10.4049/jimmunol.1401528
   Stewart WF, 2002, WORLD J UROL, V20, P327, DOI 10.1007/s00345-002-0301-4
   Sutcliffe S, 2005, AM J EPIDEMIOL, V162, P898, DOI 10.1093/aje/kwi299
   Tai HC, 2010, J CLIN ENDOCR METAB, V95, P1143, DOI 10.1210/jc.2009-1492
   Tsai YC, 2009, INT UROL NEPHROL, V41, P795, DOI 10.1007/s11255-009-9523-3
   Tyagi P, 2010, INT UROL NEPHROL, V42, P629, DOI 10.1007/s11255-009-9647-5
   Uzun H, 2012, INT NEUROUROL J, V16, P181, DOI 10.5213/inj.2012.16.4.181
   Uzun H, 2012, UROLOGY, V79, P72, DOI 10.1016/j.urology.2011.08.050
   Vignozzi L, 2014, J SEX MED, V11, P1159, DOI 10.1111/jsm.12478
   Vykhovanets EV, 2011, PROSTATE, V71, P147, DOI 10.1002/pros.21230
   Wang LW, 2014, INT UROL NEPHROL, V46, P341, DOI 10.1007/s11255-013-0540-x
   Welch G, 2002, UROLOGY, V59, P245, DOI 10.1016/S0090-4295(01)01506-0
   Zlotta AR, 2014, EUR UROL, V66, P619, DOI 10.1016/j.eururo.2014.06.026
NR 81
TC 64
Z9 71
U1 2
U2 18
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 1365-7852
EI 1476-5608
J9 PROSTATE CANCER P D
JI Prostate Cancer Prostatic Dis.
PD MAR
PY 2016
VL 19
IS 1
BP 7
EP 13
DI 10.1038/pcan.2015.43
PG 7
WC Oncology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Urology & Nephrology
GA DD3IT
UT WOS:000369816300002
PM 26391088
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Mohsenpour, MA
   Mohammadi, F
   Razmjooei, N
   Eftekhari, MH
   Hejazi, N
AF Mohsenpour, Mohammad Ali
   Mohammadi, Farzaneh
   Razmjooei, Nadia
   Eftekhari, Mohammad Hassan
   Hejazi, Najmeh
TI Milk kefir drink may not reduce depression in patients with
   non-alcoholic fatty liver disease: secondary outcome analysis of a
   randomized, single-blinded, controlled clinical trial
SO BMC NUTRITION
LA English
DT Article
DE Non-alcoholic fatty liver disease; Depression; Depressive disorder;
   Milk; Kefir
ID METABOLIC SYNDROME; ASSOCIATIONS; CONSUMPTION; DISORDER; YOGURT
AB BackgroundDepression is prevalent among individuals with non-alcoholic fatty liver disease (NAFLD) and can cause poor health outcomes. Moreover, a solid bilateral association between NAFLD and depression has been shown, which may alleviate by kefir consumption. Thus, we aimed to investigate the effect of milk kefir drinks on the depression status of individuals with NAFLD.MethodsIn a secondary outcome analysis of a randomized, single-blinded, controlled clinical trial, 80 adults with grades 1 to 3 of NAFLD were included in an 8-week intervention. Participants were randomly assigned to Diet or Diet + kefir groups to either follow a low-calorie diet or a low-calorie diet along with a 500 cc milk kefir drink daily. The participants' demographic, anthropometric, dietary, and physical data were recorded before and after the study. Depression status was assessed using the Persian format of the second version of the Beck Depression Inventory (BDI-II-Persian) at the baseline and after 8 weeks of intervention.ResultsOverall, 80 participants aged 42.87 & PLUSMN; 10.67 years were included in the analysis. The data on the baseline demographic, dietary, and physical activity of the groups were not significantly different. During the study, participants in Diet + Kefir group had a significantly decreased energy (P = 0.02), carbohydrate (P = 0.4), and fat consumption (P = 0.4). However, during the study, the depression score was not significantly reduced in the Diet group, the Diet + Kefir group showed a significant reduction in depression (P = 0.02). However, between-group analyses for changes in depression were not significant (P = 0.59).ConclusionConsumption of milk kefir drink for 8 weeks may not reduce depression symptoms in adults with NAFLD.
C1 [Mohsenpour, Mohammad Ali; Mohammadi, Farzaneh] Shiraz Univ Med Sci, Student Res Comm, Shiraz, Iran.
   [Mohsenpour, Mohammad Ali; Mohammadi, Farzaneh; Razmjooei, Nadia; Eftekhari, Mohammad Hassan; Hejazi, Najmeh] Shiraz Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Shiraz, Iran.
C3 Shiraz University of Medical Science; Shiraz University of Medical
   Science
RP Hejazi, N (corresponding author), Shiraz Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Shiraz, Iran.
EM najmehhejazi@gmail.com
RI Mohsenpour, Mohammad Ali/GYA-4997-2022; Hejazi, Najmeh/R-4345-2017;
   Mohammadi, Farzaneh/IYJ-7537-2023
OI Mohsenpour, Mohammad Ali/0000-0001-6885-1993; Mohammadi,
   Farzaneh/0000-0002-0088-4729
FU Shiraz University of Medical Sciences
FX The Authors send warm regards to the participants of the study. The
   research team would like to thank the staff of Motahari Clinic for their
   cooperation and the vice-chancellor for research of Shiraz University of
   Medical Sciences for financial support of the study. The authors would
   like to thank Shiraz University of Medical Sciences, Shiraz, Iran and
   also Center for Development of Clinical Research of Nemazee Hospital and
   Dr. Nasrin Shokrpour for editorial assistance.
CR Akkasheh G, 2016, NUTRITION, V32, P315, DOI 10.1016/j.nut.2015.09.003
   Aron-Wisnewsky J, 2020, NAT REV GASTRO HEPAT, V17, P279, DOI 10.1038/s41575-020-0269-9
   Azizi NF, 2021, FOODS, V10, DOI 10.3390/foods10061210
   Birk JL, 2019, HEALTH PSYCHOL, V38, P802, DOI 10.1037/hea0000737
   Chen HL, 2021, J DAIRY SCI, V104, P6415, DOI 10.3168/jds.2020-19222
   Cherian L, 2021, J GERONTOL A-BIOL, V76, P151, DOI 10.1093/gerona/glaa044
   Clarke DM, 2009, MED J AUSTRALIA, V190, pS54
   Daut RA, 2019, FRONT NEUROENDOCRIN, V54, DOI 10.1016/j.yfrne.2019.04.003
   Fresán U, 2019, EUR J NUTR, V58, P1271, DOI 10.1007/s00394-018-1653-x
   Ganji V, 2004, AM J CLIN NUTR, V80, P1500, DOI 10.1093/ajcn/80.6.1500
   Garofalo C, 2020, FOOD RES INT, V137, DOI 10.1016/j.foodres.2020.109369
   Gawlik-Kotelnicka O, 2021, LIFE-BASEL, V11, DOI 10.3390/life11020117
   Gharraee Banafsheh, 2019, Med J Islam Repub Iran, V33, P151, DOI 10.34171/mjiri.33.151
   Ghassemzadeh H, 2005, DEPRESS ANXIETY, V21, P185, DOI 10.1002/da.20070
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Peluzio MDG, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.638740
   He LH, 2021, FRONT MICROBIOL, V12, DOI 10.3389/fmicb.2021.761836
   Kaluzna-Czaplinska J, 2019, CRIT REV FOOD SCI, V59, P72, DOI 10.1080/10408398.2017.1357534
   Katritch V, 2011, NEUROPHARMACOLOGY, V60, P108, DOI 10.1016/j.neuropharm.2010.07.009
   KNAPP S, 1975, LIFE SCI, V16, P1583, DOI 10.1016/0024-3205(75)90076-4
   Kraus C, 2017, NEUROSCI BIOBEHAV R, V77, P317, DOI 10.1016/j.neubiorev.2017.03.007
   Labenz C, 2020, HEPATOL COMMUN, V4, P1293, DOI 10.1002/hep4.1541
   Lee PH, 2011, INT J BEHAV NUTR PHY, V8, DOI 10.1186/1479-5868-8-115
   Lim GY, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-21243-x
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Mahan LK, 2016, Krauses Food the Nutrition Care Process-E-Book: Krauses Food the Nutrition Care Process-E-Book
   Mantovani A, 2020, METABOLISM, V111, DOI 10.1016/j.metabol.2020.154170
   Mathers CD, 2006, PLOS MED, V3, DOI 10.1371/journal.pmed.0030442
   Mohammadi F, 2023, EFFECTS MILK K UNPUB
   Moussavi S, 2007, LANCET, V370, P851, DOI 10.1016/S0140-6736(07)61415-9
   Nabavi S, 2014, J DAIRY SCI, V97, P7386, DOI 10.3168/jds.2014-8500
   Nikolova V, 2019, THER ADV PSYCHOPHARM, V9, DOI 10.1177/2045125319859963
   Noori Negin, 2014, Adv Biomed Res, V3, P251, DOI 10.4103/2277-9175.146377
   Özcan H, 2019, HOLIST NURS PRACT, V33, P207, DOI 10.1097/HNP.0000000000000310
   Roriz-Cruz M, 2007, J AM GERIATR SOC, V55, P374, DOI 10.1111/j.1532-5415.2007.01068.x
   Salari-Moghaddam A, 2019, J AFFECT DISORDERS, V256, P96, DOI 10.1016/j.jad.2019.05.056
   Sayiner M, 2020, HEPATOL INT, V14, P556, DOI 10.1007/s12072-020-10038-w
   Sun J, 2020, J AFFECT DISORDERS, V274, P326, DOI 10.1016/j.jad.2020.05.095
   Sun Y, 2019, FOOD FUNCT, V10, P925, DOI [10.1039/c8fo02096e, 10.1039/C8FO02096E]
   Tomeno W, 2015, J GASTROEN HEPATOL, V30, P1009, DOI 10.1111/jgh.12897
   van de Wouw M, 2020, MICROBIOME, V8, DOI 10.1186/s40168-020-00846-5
   Waclawiková B, 2018, PHARMACEUTICALS-BASE, V11, DOI 10.3390/ph11030063
   Xiao JL, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.691696
NR 43
TC 5
Z9 5
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2055-0928
J9 BMC NUTR
JI BMC Nutr.
PD JUN 29
PY 2023
VL 9
IS 1
AR 80
DI 10.1186/s40795-023-00732-x
PG 9
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA L1RQ0
UT WOS:001021102200002
PM 37386551
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Stranahan, AM
   Mattson, MP
AF Stranahan, Alexis M.
   Mattson, Mark P.
TI Recruiting adaptive cellular stress responses for successful brain
   ageing
SO NATURE REVIEWS NEUROSCIENCE
LA English
DT Review
ID BODY-MASS INDEX; HIPPOCAMPAL OXIDATIVE STRESS; HIGH-FAT DIET;
   NEUROTROPHIC FACTOR; COGNITIVE DECLINE; SYNAPTIC PLASTICITY; BEHAVIORAL
   DEFICITS; LIPID-PEROXIDATION; METABOLIC SYNDROME; IMPROVES MEMORY
AB Successful ageing is determined in part by genetic background, but also by experiential factors associated with lifestyle and culture. Dietary, behavioural and pharmacological interventions have been identified as potential means to slow brain ageing and forestall neurodegenerative disease. Many of these interventions recruit adaptive cellular stress responses to strengthen neuronal networks and enhance plasticity. In this Science and Society article, we describe several determinants of healthy and pathological brain ageing, with insights into how these processes are accelerated or prevented. We also describe the mechanisms underlying the neuroprotective actions of exercise and nutritional interventions, with the goal of recruiting these molecular targets for the treatment and prevention of neurodegenerative disease.
C1 [Mattson, Mark P.] NIH, Neurosci Lab, Natl Inst Ageing Intramural Res Program, Baltimore, MD 21224 USA.
   [Stranahan, Alexis M.] Georgia Hlth Sci Univ, Dept Physiol, Augusta, GA 30912 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); University System of Georgia; Augusta University
RP Mattson, MP (corresponding author), NIH, Neurosci Lab, Natl Inst Ageing Intramural Res Program, Baltimore, MD 21224 USA.
EM mattsonm@grc.nia.nih.gov
RI Stranahan, Alexis/AAF-3559-2020; Mattson, Mark/F-6038-2012
FU National Institute on Aging
FX This work was supported by the Intramural Research Program of the
   National Institute on Aging.
CR Albert MS, 1997, PHILOS T ROY SOC B, V352, P1703, DOI 10.1098/rstb.1997.0152
   Arumugam TV, 2010, ANN NEUROL, V67, P41, DOI 10.1002/ana.21798
   Barrientos RM, 2011, J NEUROSCI, V31, P11578, DOI 10.1523/JNEUROSCI.2266-11.2011
   Behl C, 2002, NAT REV NEUROSCI, V3, P433, DOI 10.1038/nrn846
   Bingol B, 2011, NEURON, V69, P22, DOI 10.1016/j.neuron.2010.11.006
   Bremner J. Douglas, 2006, CNS & Neurological Disorders-Drug Targets, V5, P503
   Burns JM, 2010, ARCH NEUROL-CHICAGO, V67, P428, DOI 10.1001/archneurol.2010.38
   Calabrese EJ, 2007, TOXICOL APPL PHARM, V222, P122, DOI 10.1016/j.taap.2007.02.015
   Calabrese V, 2010, ANTIOXID REDOX SIGN, V13, P1763, DOI 10.1089/ars.2009.3074
   Debette S, 2011, NEUROLOGY, V77, P461, DOI 10.1212/WNL.0b013e318227b227
   Dei R, 2002, ACTA NEUROPATHOL, V104, P113, DOI 10.1007/s00401-002-0523-y
   Diano S, 2006, NAT NEUROSCI, V9, P381, DOI 10.1038/nn1656
   Duan WZ, 1999, J NEUROSCI RES, V57, P195, DOI 10.1002/(SICI)1097-4547(19990715)57:2<195::AID-JNR5>3.0.CO;2-P
   Duan WZ, 2003, P NATL ACAD SCI USA, V100, P2911, DOI 10.1073/pnas.0536856100
   Fergenbaum JH, 2009, OBESITY, V17, P1957, DOI 10.1038/oby.2009.161
   Floyd RA, 2002, NEUROBIOL AGING, V23, P795, DOI 10.1016/S0197-4580(02)00019-2
   Fontán-Lozano A, 2007, J NEUROSCI, V27, P10185, DOI 10.1523/JNEUROSCI.2757-07.2007
   GALLAGHER M, 1993, BEHAV NEUROSCI, V107, P618, DOI 10.1037/0735-7044.107.4.618
   Garcia C, 2003, NEUROSCIENCE, V119, P721, DOI 10.1016/S0306-4522(03)00192-1
   Gibson GE, 2010, BBA-MOL BASIS DIS, V1802, P122, DOI 10.1016/j.bbadis.2009.08.010
   Gleichmann M, 2011, J ALZHEIMERS DIS, V24, P15, DOI 10.3233/JAD-2010-101674
   GOODRICK CL, 1984, AGE, V7, P1, DOI 10.1007/BF02431887
   Granholm AC, 2008, J ALZHEIMERS DIS, V14, P133
   GREENWOOD CE, 1990, BEHAV NEURAL BIOL, V53, P74, DOI 10.1016/0163-1047(90)90831-P
   Gunstad J, 2007, COMPR PSYCHIAT, V48, P57, DOI 10.1016/j.comppsych.2006.05.001
   Guo Q, 1999, NAT MED, V5, P101, DOI 10.1038/4789
   Halagappa VKM, 2007, NEUROBIOL DIS, V26, P212, DOI 10.1016/j.nbd.2006.12.019
   Hargus G, 2010, P NATL ACAD SCI USA, V107, P15921, DOI 10.1073/pnas.1010209107
   Harvey J, 2007, CURR OPIN PHARMACOL, V7, P643, DOI 10.1016/j.coph.2007.10.006
   Heneka MT, 2006, J NEUROSCI, V26, P1343, DOI 10.1523/JNEUROSCI.4236-05.2006
   Huizinga MM, 2008, OBESITY, V16, P1966, DOI 10.1038/oby.2008.294
   Hyun DH, 2006, P NATL ACAD SCI USA, V103, P19908, DOI 10.1073/pnas.0608008103
   Inui A, 2001, NAT REV NEUROSCI, V2, P551, DOI 10.1038/35086018
   Johansson I, 2008, ENDOCRINOLOGY, V149, P2191, DOI 10.1210/en.2007-0733
   Kanoski SE, 2007, BEHAV BRAIN RES, V182, P57, DOI 10.1016/j.bbr.2007.05.004
   Kanoski SE, 2011, PHYSIOL BEHAV, V103, P59, DOI 10.1016/j.physbeh.2010.12.003
   Kanoski SE, 2010, J ALZHEIMERS DIS, V21, P207, DOI 10.3233/JAD-2010-091414
   Kapogiannis D, 2011, LANCET NEUROL, V10, P187, DOI 10.1016/S1474-4422(10)70277-5
   Karuppagounder SS, 2009, NEUROBIOL AGING, V30, P1587, DOI 10.1016/j.neurobiolaging.2007.12.013
   Kim SJ, 2008, J BIOL CHEM, V283, P14497, DOI 10.1074/jbc.M708373200
   Kraft AD, 2004, J NEUROSCI, V24, P1101, DOI 10.1523/JNEUROSCI.3817-03.2004
   Kruman II, 2002, J NEUROSCI, V22, P1752, DOI 10.1523/JNEUROSCI.22-05-01752.2002
   Lazarov O, 2010, TRENDS NEUROSCI, V33, P569, DOI 10.1016/j.tins.2010.09.003
   Lee J, 2002, J NEUROCHEM, V82, P1367, DOI 10.1046/j.1471-4159.2002.01085.x
   Li YF, 2008, OBESITY, V16, P1809, DOI 10.1038/oby.2008.296
   Lindvall O, 2010, J CLIN INVEST, V120, P29, DOI 10.1172/JCI40543
   Lovell MA, 1997, NEUROBIOL AGING, V18, P457, DOI 10.1016/S0197-4580(97)00108-5
   Ma QL, 2009, J NEUROSCI, V29, P9078, DOI 10.1523/JNEUROSCI.1071-09.2009
   Massa SM, 2010, J CLIN INVEST, V120, P1774, DOI 10.1172/JCI41356
   Maswood N, 2004, P NATL ACAD SCI USA, V101, P18171, DOI 10.1073/pnas.0405831102
   Mattson MP, 2008, AGEING RES REV, V7, P1, DOI 10.1016/j.arr.2007.08.007
   Mattson MP, 2009, EXP GERONTOL, V44, P625, DOI 10.1016/j.exger.2009.07.003
   Mattson MP, 2008, NEURON, V60, P748, DOI 10.1016/j.neuron.2008.10.010
   Mattson MP, 2006, NAT REV NEUROSCI, V7, P278, DOI 10.1038/nrn1886
   Mattson MP, 2003, NAT MED, V9, P1113, DOI 10.1038/nm0903-1113
   Mattson MP, 1998, TRENDS NEUROSCI, V21, P53, DOI 10.1016/S0166-2236(97)01188-0
   McNay EC, 2010, NEUROBIOL LEARN MEM, V93, P546, DOI 10.1016/j.nlm.2010.02.002
   Mielke JG, 2006, BEHAV BRAIN RES, V175, P374, DOI 10.1016/j.bbr.2006.09.010
   Mirescu C, 2006, HIPPOCAMPUS, V16, P233, DOI 10.1002/hipo.20155
   Moloney AM, 2010, NEUROBIOL AGING, V31, P224, DOI 10.1016/j.neurobiolaging.2008.04.002
   Molteni R, 2002, NEUROSCIENCE, V112, P803, DOI 10.1016/S0306-4522(02)00123-9
   Morrison CD, 2010, J NEUROCHEM, V114, P1581, DOI 10.1111/j.1471-4159.2010.06865.x
   Nagahara AH, 2011, NAT REV DRUG DISCOV, V10, P209, DOI 10.1038/nrd3366
   Naidoo N, 2008, J NEUROSCI, V28, P6539, DOI 10.1523/JNEUROSCI.5685-07.2008
   Nicolle MM, 2001, NEUROSCIENCE, V107, P415, DOI 10.1016/S0306-4522(01)00374-8
   Obregon DF, 2006, J BIOL CHEM, V281, P16419, DOI 10.1074/jbc.M600617200
   Olanow CW, 2009, ANN NEUROL, V66, P591, DOI 10.1002/ana.21778
   Parachikova A, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0014015
   Park SS, 2011, BMC NEUROSCI, V12, DOI 10.1186/1471-2202-12-63
   Porter DW, 2010, DIABETES OBES METAB, V12, P891, DOI 10.1111/j.1463-1326.2010.01259.x
   Robitsek RJ, 2008, J NEUROSCI, V28, P8945, DOI 10.1523/JNEUROSCI.1893-08.2008
   Roriz-Cruz M, 2007, NEUROBIOL AGING, V28, P1723, DOI 10.1016/j.neurobiolaging.2006.07.013
   Rothman SM, 2012, NEUROBIOL AGING, V33, DOI 10.1016/j.neurobiolaging.2011.07.005
   Sabia S, 2009, AM J CLIN NUTR, V89, P601, DOI 10.3945/ajcn.2008.26482
   Son TG, 2010, J NEUROCHEM, V112, P1316, DOI 10.1111/j.1471-4159.2009.06552.x
   Son TG, 2008, NEUROMOL MED, V10, P236, DOI 10.1007/s12017-008-8037-y
   Spencer JPE, 2010, BRIT J NUTR, V104, pS40, DOI 10.1017/S0007114510003934
   Stone AA, 2010, P NATL ACAD SCI USA, V107, P9985, DOI 10.1073/pnas.1003744107
   Stranahan AM, 2008, HIPPOCAMPUS, V18, P1085, DOI 10.1002/hipo.20470
   Stranahan AM, 2008, NAT NEUROSCI, V11, P309, DOI 10.1038/nn2055
   Stranahan AM, 2010, NEUROBIOL AGING, V31, P1937, DOI 10.1016/j.neurobiolaging.2008.10.016
   Stranahan AM, 2009, HIPPOCAMPUS, V19, P951, DOI 10.1002/hipo.20577
   Stranahan AM, 2008, NEUROMOL MED, V10, P209, DOI 10.1007/s12017-008-8043-0
   Stranahan AM, 2006, NAT NEUROSCI, V9, P526, DOI 10.1038/nn1668
   Sturman MT, 2008, NEUROLOGY, V70, P360, DOI 10.1212/01.wnl.0000285081.04409.bb
   van den Berg E, 2007, NEUROLOGY, V69, P979, DOI 10.1212/01.wnl.0000271381.30143.75
   Vingtdeux V, 2010, J BIOL CHEM, V285, P9100, DOI 10.1074/jbc.M109.060061
   Wang GJ, 2008, OBESITY, V16, pS88, DOI 10.1038/oby.2008.469
   Weissman L, 2007, NUCLEIC ACIDS RES, V35, P5545, DOI 10.1093/nar/gkm605
   Witte AV, 2009, P NATL ACAD SCI USA, V106, P1255, DOI 10.1073/pnas.0808587106
   Wong E, 2010, NAT NEUROSCI, V13, P805, DOI 10.1038/nn.2575
   Wu P, 2008, NEUROBIOL AGING, V29, P1502, DOI 10.1016/j.neurobiolaging.2007.03.028
   Xu X, 2007, GENOME BIOL, V8, DOI 10.1186/gb-2007-8-11-r234
   Yang JL, 2010, J BIOL CHEM, V285, P28191, DOI 10.1074/jbc.M109.082883
   ZYZAK DR, 1995, LEARN MEMORY, V2, P1, DOI 10.1101/lm.2.1.1
NR 95
TC 124
Z9 145
U1 0
U2 39
PU NATURE RESEARCH
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 1471-003X
EI 1471-0048
J9 NAT REV NEUROSCI
JI Nat. Rev. Neurosci.
PD MAR
PY 2012
VL 13
IS 3
BP 209
EP 216
DI 10.1038/nrn3151
PG 8
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 897GR
UT WOS:000300636500014
PM 22251954
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lin, Y
   Ni, XY
   Zhu, L
   Lin, YL
   Peng, C
   Lei, Z
   Wang, YH
   Wang, H
   You, X
   Li, J
   Shen, HQ
   Wei, J
AF Lin, Yi
   Ni, Xiuye
   Zhu, Lin
   Lin, Yilong
   Peng, Cai
   Lei, Zhao
   Wang, Yihui
   Wang, Huan
   You, Xiang
   Li, Juan
   Shen, Heqing
   Wei, Jie
TI Multi-miRNAs-Mediated Hepatic Lepr Axis Suppression: A Pparg-Dicer1
   Pathway-Driven Mechanism in Spermatogenesis for the Intergenerational
   Transmission of Paternal Metabolic Syndrome
SO ADVANCED SCIENCE
LA English
DT Article
DE bisphenol A; intergenerational transmission; leptin resistance;
   metabolic syndrome; microRNAs
ID NONALCOHOLIC FATTY LIVER; PPAR-GAMMA; BISPHENOL-A; PERINATAL EXPOSURE;
   SPERM; EXPRESSION; REPROGRAMS; STRESS; INHERITANCE; DISORDERS
AB Bisphenol A (BPA) is an "environmental obesogen" and this study aims to investigate the intergenerational impacts of BPA-induced metabolic syndrome (MetS), specifically focusing on unraveling mechanisms. Exposure to BPA induces metabolic disorders in the paternal mice, which are then transmitted to offspring, leading to late-onset MetS. Mechanistically, BPA upregulates Srebf1, which in turn promotes the Pparg-dependent transcription of Dicer1 in spermatocytes, increasing the levels of multiple sperm microRNAs (miRNAs). Several of these miRNAs are highly expressed in a synchronized manner in liver of the offspring. miR149-5p, miR150-5p, and miR700-5p target a specific region in the Lepr 3 ' UTR, termed "SMITE" ("Several MiRNAs Targeting Elements"), to negatively regulate Lepr. These inherited anti-Lepr miRNAs, also referred to inherited anti-Lepr miRNAs (IAL-miRs), modulate hepatic steatosis, and insulin signaling through the Lepr regulatory Igfbp2, Egfr, and Ampk. Furthermore, IAL-miRs inhibit Ccnd1 not only via binding to "SMITE" but also via Lepr-Igfbp2 axis, which contribute to hepatocyte senescence. These pathological processes interact in a self-reinforcing cycle, worsening MetS in the paternal BPA-exposed offspring. The findings reveal mechanism wherein lipid metabolism reprogramming in spermatocytes-induced perturbations of sperm miRNAs, triggered by BPA, leads to intergenerational inheritance of paternal MetS through suppression of the hepatic Lepr axis in the offspring.
C1 [Lin, Yi; Ni, Xiuye; Zhu, Lin; Lei, Zhao; Wang, Yihui; Wang, Huan; Shen, Heqing] Xiamen Univ, Sch Publ Hlth, State Key Lab Vaccines Infect Dis, Xiang Biomed Lab,Natl Innovat Platform Ind Educ In, Xiamen 361102, Peoples R China.
   [Lin, Yi] Xiamen Univ, Sch Med, Dept Basic Med Sci, Xiamen 361102, Peoples R China.
   [Lin, Yilong; Peng, Cai; You, Xiang; Li, Juan; Wei, Jie] Xiamen Univ, Fujian Key Lab Coastal Pollut Prevent & Control, Xiamen 361102, Peoples R China.
C3 Xiamen University; Xiamen University; Xiamen University
RP Lin, Y; Shen, HQ (corresponding author), Xiamen Univ, Sch Publ Hlth, State Key Lab Vaccines Infect Dis, Xiang Biomed Lab,Natl Innovat Platform Ind Educ In, Xiamen 361102, Peoples R China.; Wei, J (corresponding author), Xiamen Univ, Fujian Key Lab Coastal Pollut Prevent & Control, Xiamen 361102, Peoples R China.
EM tjlinyi@xmu.edu.cn; hqshen@xmu.edu.cn; jiewei@xmu.edu.cn
RI Wang, Yihui/GQY-8908-2022
FU National Natural Science Foundation of China; Natural Science Foundation
   of Fujian [2023J01039, 2021J01012]; Scientific Research Support Program
   for Young Teachers of School of Medicine, Xiamen University; 
   [82073505];  [81502782];  [21677140];  [22076158]
FX Y.L., X.N., L.Z., and Y.L. contributed equally to this work. This work
   was supported by the National Natural Science Foundation of China
   (82073505, 81502782, 21677140, and 22076158), the Natural Science
   Foundation of Fujian (2023J01039 and 2021J01012), and the Scientific
   Research Support Program for Young Teachers of School of Medicine,
   Xiamen University. The authors thank Luming Yao and Caiming Wu in the
   School of Life Sciences, Xiamen University for their assistance in the
   preparation and imaging of the electron microscopy sample, and thank
   Jingru Huang in the School of Medicine, Xiamen University for her
   assistance in the confocal microscopy analyses.
CR Ahmadian M, 2013, NAT MED, V19, P557, DOI 10.1038/nm.3159
   Al Zein M, 2024, OBES REV, V25, DOI 10.1111/obr.13807
   Alkhazaali-Ali Z, 2024, BIOMED PHARMACOTHER, V177, DOI 10.1016/j.biopha.2024.116899
   Ardestani A, 2020, CELL METAB, V31, P6, DOI 10.1016/j.cmet.2019.12.006
   Barbosa TD, 2016, MOL METAB, V5, P184, DOI 10.1016/j.molmet.2015.12.002
   Behera J, 2022, DIABETES, V71, P2777, DOI 10.2337/db21-0573
   Bhushan B, 2019, HEPATOLOGY, V70, P1546, DOI 10.1002/hep.30696
   Carone BR, 2010, CELL, V143, P1084, DOI 10.1016/j.cell.2010.12.008
   Carter T, 2023, BMC PUBLIC HEALTH, V23, DOI 10.1186/s12889-023-15335-1
   Carver RS, 2002, GASTROENTEROLOGY, V123, P2017, DOI 10.1053/gast.2002.37060
   Chen H, 2023, PHARMACOL THERAPEUT, V245, DOI 10.1016/j.pharmthera.2023.108391
   Chen Q, 2016, SCIENCE, V351, P397, DOI 10.1126/science.aad7977
   Chen THH, 2006, AM J CLIN NUTR, V83, P688, DOI 10.1093/ajcn.83.3.688
   Chew NWS, 2023, CELL METAB, V35, P414, DOI 10.1016/j.cmet.2023.02.003
   Chin C, 2023, CELL REP MED, V4, DOI 10.1016/j.xcrm.2023.100945
   Cohen P, 2005, J BIOL CHEM, V280, P10034, DOI 10.1074/jbc.M413684200
   Cropley JE, 2016, MOL METAB, V5, P699, DOI 10.1016/j.molmet.2016.06.008
   Dai JB, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-07920-3
   De Jesus DF, 2020, J CLIN INVEST, V130, P2391, DOI 10.1172/JCI127502
   Dueñnas-Moreno J, 2023, ENVIRON INT, V181, DOI 10.1016/j.envint.2023.108294
   Faramia J, 2021, CELL REP MED, V2, DOI 10.1016/j.xcrm.2021.100248
   Gao CZ, 2021, ENVIRON SCI TECHNOL, V55, P1953, DOI 10.1021/acs.est.0c07587
   Gapp K, 2014, NAT NEUROSCI, V17, P667, DOI 10.1038/nn.3695
   García MG, 2024, NUTRIENTS, V16, DOI 10.3390/nu16213740
   González-Casanova JE, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24098231
   Guan DX, 2024, CELL METAB, V36, DOI 10.1016/j.cmet.2024.02.007
   He B, 2024, ENVIRON POLLUT, V357, DOI 10.1016/j.envpol.2024.124447
   Hevener AL, 2003, NAT MED, V9, P1491, DOI 10.1038/nm956
   Hogh KLN, 2014, ENDOCRINOLOGY, V155, P3843, DOI 10.1210/en.2014-1076
   Huang L, 2001, J BIOL CHEM, V276, P6343, DOI 10.1074/jbc.M009795200
   Huang XW, 2023, CELL CYCLE, V22, P2361, DOI 10.1080/15384101.2023.2287367
   Huang YC, 2014, TOXICOL IND HEALTH, V30, P182, DOI 10.1177/0748233712452606
   Jones RL, 2018, ENVIRON HEALTH PERSP, V126, DOI [10.1289/EHP3802, 10.1289/ehp3802]
   Jung YH, 2022, P NATL ACAD SCI USA, V119, DOI 10.1073/pnas.2214988119
   Kang MS, 2018, METABOLISM, V83, P139, DOI 10.1016/j.metabol.2017.12.018
   Kodila A, 2023, ARCH TOXICOL, V97, P1831, DOI 10.1007/s00204-023-03519-y
   La Merrill MA, 2025, NAT REV ENDOCRINOL, V21, P245, DOI 10.1038/s41574-024-01059-8
   Landt M, 2000, CLIN CHEM, V46, P379
   Laphanuwat P, 2018, J CELL SCI, V131, DOI 10.1242/jcs.214726
   Lee DH, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms242216531
   Leggio L, 2025, MOL CELL BIOCHEM, V480, P659, DOI 10.1007/s11010-024-04962-w
   Li T, 2020, CANCER LETT, V477, P19, DOI 10.1016/j.canlet.2020.02.036
   Lin Y, 2013, CELL DEATH DIS, V4, DOI 10.1038/cddis.2012.206
   Lin Y, 2017, BBA-MOL CELL BIOL L, V1862, P869, DOI 10.1016/j.bbalip.2017.05.001
   Liu BL, 2023, CELL DEATH DIS, V14, DOI 10.1038/s41419-023-05623-4
   Liu JW, 2023, ENVIRON INT, V172, DOI 10.1016/j.envint.2023.107769
   Liu JT, 2023, ECOTOX ENVIRON SAFE, V255, DOI 10.1016/j.ecoenv.2023.114769
   Luo J, 2023, ISCIENCE, V26, DOI 10.1016/j.isci.2023.107837
   Luo X, 2018, CELL DEATH DIS, V9, DOI 10.1038/s41419-018-0969-z
   Maestri A, 2024, AGEING RES REV, V94, DOI 10.1016/j.arr.2024.102194
   Matsusue K, 2003, J CLIN INVEST, V111, P737, DOI 10.1172/JCI200317223
   Mina AI, 2018, CELL METAB, V28, P656, DOI 10.1016/j.cmet.2018.06.019
   Nikkola E, 2017, ATHEROSCLEROSIS, V264, P58, DOI 10.1016/j.atherosclerosis.2017.07.024
   Qiu YH, 2023, INT J BIOL MACROMOL, V253, DOI 10.1016/j.ijbiomac.2023.127042
   Rahman MS, 2021, J HAZARD MATER, V416, DOI 10.1016/j.jhazmat.2021.125791
   Rahman MS, 2020, HUM REPROD, V35, P1740, DOI 10.1093/humrep/deaa139
   Rashid CS, 2020, FOOD CHEM TOXICOL, V145, DOI 10.1016/j.fct.2020.111716
   Rauzier C, 2023, AM J PHYSIOL-ENDOC M, V325, pE99, DOI 10.1152/ajpendo.00108.2023
   Rieusset J, 2002, MOL ENDOCRINOL, V16, P2628, DOI 10.1210/me.2002-0036
   Rodgers AB, 2013, J NEUROSCI, V33, P9003, DOI 10.1523/JNEUROSCI.0914-13.2013
   Sales VM, 2017, CELL METAB, V25, P559, DOI 10.1016/j.cmet.2017.02.016
   Sánchez-González I, 2020, CANCER RES, V80, P1330, DOI 10.1158/0008-5472.CAN-19-1934
   Shao F, 2023, FEBS LETT, V597, P1503, DOI 10.1002/1873-3468.14636
   Sharma U, 2016, SCIENCE, V351, P391, DOI 10.1126/science.aad6780
   Shin M, 2017, ENDOCRINOL METAB, V32, P11, DOI 10.3803/EnM.2017.32.1.11
   Sommer C, 2023, J CLIN ENDOCR METAB, V108, P1110, DOI 10.1210/clinem/dgac699
   Song P, 2023, MEDCOMM, V4, DOI 10.1002/mco2.346
   Stoeckius M, 2014, EMBO J, V33, P1740, DOI 10.15252/embj.201488117
   Sugii S, 2009, P NATL ACAD SCI USA, V106, P22504, DOI 10.1073/pnas.0912487106
   Takahashi K, 2023, CELL REP, V42, DOI 10.1016/j.celrep.2023.112415
   Tang Z, 2023, J REAL-TIME IMAGE PR, V20, DOI 10.1007/s11554-023-01281-z
   Thorson J. L. M., 2021, ENVIRON EPIGENETICS, V7, P023
   Tomar A, 2024, NATURE, V630, P720, DOI 10.1038/s41586-024-07472-3
   Triatin RD, 2023, CARDIOVASC DIABETOL, V22, DOI 10.1186/s12933-023-02017-w
   Vökel W, 2002, CHEM RES TOXICOL, V15, P1281, DOI 10.1021/tx025548t
   vom Saal FS, 2024, ENVIRON HEALTH PERSP, V132, DOI 10.1289/EHP13812
   Wang GF, 2023, MOL METAB, V73, DOI 10.1016/j.molmet.2023.101741
   Wang HT, 2023, DEV CELL, V58, P779, DOI 10.1016/j.devcel.2023.03.010
   Wang J., 2023, FASEB J, V37
   Wang YB, 2021, SCI ADV, V7, DOI 10.1126/sciadv.abd7605
   Wei J, 2017, FASEB J, V31, P5184, DOI 10.1096/fj.201700282R
   Wei J, 2014, J ENDOCRINOL, V222, P313, DOI 10.1530/JOE-14-0356
   Wei J, 2011, ENDOCRINOLOGY, V152, P3049, DOI 10.1210/en.2011-0045
   Wei YL, 2021, SCIENCE, V371, P906, DOI 10.1126/science.abb1625
   Wu L, 2016, CELL METAB, V23, P735, DOI 10.1016/j.cmet.2016.01.014
   Xi G, 2019, J CELL PHYSIOL, V234, P23232, DOI 10.1002/jcp.28890
   Xiao JJ, 2016, J CELL MOL MED, V20, P1603, DOI 10.1111/jcmm.12848
   Xie T, 2011, PHYSIOL GENOMICS, V43, P479, DOI 10.1152/physiolgenomics.00222.2010
   Yang X, 2021, PHYTOMEDICINE, V87, DOI 10.1016/j.phymed.2021.153575
   Yoo EG, 2012, DIABETES CARE, V35, P293, DOI 10.2337/dc11-1283
   Yuan MZ, 2023, ENVIRON INT, V176, DOI 10.1016/j.envint.2023.107976
   Zhang YW, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-26909-1
   Zhang YN, 2024, ENVIRON INT, V187, DOI 10.1016/j.envint.2024.108689
   Zhao JH, 2021, ONCOL REP, V46, DOI 10.3892/or.2021.8209
   Zimmers TA, 2017, AM J PHYSIOL-ENDOC M, V313, pE440, DOI 10.1152/ajpendo.00032.2017
NR 95
TC 0
Z9 0
U1 5
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2198-3844
J9 ADV SCI
JI Adv. Sci.
PD MAR
PY 2025
VL 12
IS 9
DI 10.1002/advs.202410831
EA JAN 2025
PG 22
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
   Science, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA Z6U3T
UT WOS:001393597700001
PM 39792613
OA gold
DA 2025-06-11
ER

PT J
AU LaHue, SC
   Comella, CL
   Tanner, CM
AF LaHue, Sara C.
   Comella, Cynthia L.
   Tanner, Caroline M.
TI The best medicine? The influence of physical activity and inactivity on
   Parkinson's disease
SO MOVEMENT DISORDERS
LA English
DT Review
DE Parkinson's disease; exercise; metabolic syndrome; physical activity;
   disease modification
ID BODY-MASS INDEX; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-LESIONED
   MOUSE MODEL; RANDOMIZED CONTROLLED-TRIAL; TREADMILL EXERCISE;
   ECONOMIC-EVALUATION; METABOLIC SYNDROME; COGNITIVE DECLINE;
   SUBSTANTIA-NIGRA; REDUCED RISK; FUTURE RISK
AB The incidence of Parkinson's disease (PD) is expected to increase as our population ages and will likely strain the projected capacity of our health care system. Despite being the most common movement disorder, there have been few noninvasive therapeutic advances for people with PD since the first levodopa clinical trial in 1961. The study of PD pathogenesis, combined with an appreciation for the biochemical mechanisms by which physical activity and exercise may impact physiology, has resulted in emerging hypotheses for new modifiable risk factors for PD. Physical activity and exercise as a means of preventing PD, or maintaining the functionality of people with PD, are a promising area of investigation. Conversely, physical inactivity is implicated in many disease states, some of which are also correlated with the development of PD, such as metabolic syndrome. The primary relationship between these diseases is likely rooted in heightened inflammation and oxidative stress at the cellular level. Physical activity and exercise as a means of attenuating inflammation have led to increased interest in related potential therapeutic targets for PD. Ultimately, these findings may translate into low-cost, universally available therapies for PD disease modification or prevention. (c) 2016 International Parkinson and Movement Disorder Society
C1 [LaHue, Sara C.] Kaiser Permanente San Francisco Med Ctr, San Francisco, CA USA.
   [Comella, Cynthia L.] Rush Presbyterian St Lukes Med Ctr, Neurol Sci, Chicago, IL USA.
   [Tanner, Caroline M.] San Francisco VA Med Ctr, San Francisco, CA USA.
   [Tanner, Caroline M.] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA.
C3 Kaiser Permanente; Rush University; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); San Francisco VA Medical Center;
   University of California System; University of California San Francisco
RP Tanner, CM (corresponding author), Univ Calif San Francisco, Dept Neurol, Movement Disorders & Neuromodulat Ctr, 1635 Divisadero St,Suite 515, San Francisco, CA 94115 USA.
EM caroline.tanner@ucsf.edu
FU NIH [R01NS074343, U54NS065701]; Dystonia Medical Research Foundation;
   Allergan Inc.; Impax Pharmaceuticals; Ipsen Biopharmaceuticals, Inc;
   Medtronic Inc.; Merz Pharmaceuticals; US World Meds; Acadia
   Pharmaceuticals; Teva Neurosciences; Parkinson's Disease Foundation;
   Michael J. Fox Foundation; Department of Defense; National Institutes of
   Health
FX Dr. LaHue has no disclosures. Dr. Comella serves on the editorial board
   of Clinical Neuropharmacology, Sleep Medicine, and Continuum. She
   receives research support from the NIH R01NS074343, U54NS065701,
   Dystonia Medical Research Foundation, Allergan Inc., Ipsen
   Biopharmaceuticals, Inc, and Merz Pharmaceutical. She receives
   compensation/honoraria for services as a consultant or an advisory
   committee member from Allergan, Inc, Impax Pharmaceuticals, Ipsen
   Biopharmaceuticals, Inc, Medtronic Inc., Merz Pharmaceuticals, US World
   Meds, Acadia Pharmaceuticals, and Teva Neurosciences. She receives
   royalties from Cambridge, Humana Press, and Wolters Kluwer. She receives
   research support from the Parkinson's Disease Foundation. Dr. Tanner,
   serves on the editorial boards of the Annals of Neurology, Journal of
   Parkinson's Disease, Parkinsonism and Related Disorders, and NPJ
   Parkinson's Disease. She serves on the Scientific Advisory Boards of the
   Michael J. Fox Foundation and the National Spasmodic Dysphonia
   Association as a voluntary consultant and has provided paid consulting
   services to Ultragenyx Pharmaceuticals, Neurocrine Biosciences,
   Cynapsus, and Adamas. She has received compensation for serving on Data
   Monitoring Committees from Biotie Therapeutics, Voyager Therapeutics,
   and Intec Pharma. She receives grant support from the Michael J. Fox
   Foundation, the Parkinson's Disease Foundation, the Department of
   Defense, and the National Institutes of Health.
CR Abbott R. D., 2002, Neurology, V59, P1051
   Agim ZS, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/672838
   Ahlskog JE, 2011, NEUROLOGY, V77, P288, DOI 10.1212/WNL.0b013e318225ab66
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   [Anonymous], 2008, DIABETES CARE, DOI DOI 10.2337/dc08-0688
   Ascherio A, 2001, ANN NEUROL, V50, P56, DOI 10.1002/ana.1052
   Aviles-Olmos I, 2013, J CLIN INVEST, V123, P2730, DOI 10.1172/JCI68295
   Bloem BR, 2015, MOVEMENT DISORD, V30, P1504, DOI 10.1002/mds.26363
   Booth FW, 2012, COMPR PHYSIOL, V2, P1143, DOI 10.1002/cphy.c110025
   Buchman AS, 2012, NEUROLOGY, V78, P1323, DOI 10.1212/WNL.0b013e3182535d35
   CASPERSEN CJ, 1985, PUBLIC HEALTH REP, V100, P126
   Cassani E, 2015, PARKINSONISM RELAT D, V21, P389, DOI 10.1016/j.parkreldis.2015.02.004
   Caudle WM, 2007, NEUROSCI LETT, V418, P213, DOI 10.1016/j.neulet.2006.03.045
   Cereda E, 2012, NEUROLOGY, V78, P1507, DOI 10.1212/WNL.0b013e3182553cc9
   Cereda E, 2013, MOVEMENT DISORD, V28, P257, DOI 10.1002/mds.25211
   Checkoway H, 1999, EPIDEMIOLOGY, V10, P327, DOI 10.1097/00001648-199905000-00023
   Chen H, 2005, NEUROLOGY, V64, P664, DOI 10.1212/01.WNL.0000151960.28687.93
   Chen H, 2008, AM J EPIDEMIOL, V167, P90, DOI 10.1093/aje/kwm260
   Chen J, 2014, Int J Endocrinol, V2014, DOI DOI 10.1155/2014/203930
   Connolly BS, 2014, JAMA-J AM MED ASSOC, V311, P1670, DOI 10.1001/jama.2014.3654
   Corcos DM, 2013, MOVEMENT DISORD, V28, P1230, DOI 10.1002/mds.25380
   Cornier MA, 2008, ENDOCR REV, V29, P777, DOI 10.1210/er.2008-0024
   David FJ, 2015, MOVEMENT DISORD, V30, P1657, DOI 10.1002/mds.26291
   de Lau LML, 2006, LANCET NEUROL, V5, P525, DOI 10.1016/S1474-4422(06)70471-9
   Dias V, 2013, J PARKINSON DIS, V3, P461, DOI 10.3233/JPD-130230
   DiFrancisco-Donoghue J, 2012, NEURODEGENER DIS, V10, P127, DOI 10.1159/000333790
   Duncan RP, 2012, NEUROREHAB NEURAL RE, V26, P132, DOI 10.1177/1545968311421614
   Ellis T, 2013, PHYS THER, V93, P628, DOI 10.2522/ptj.20120279
   Farag I, 2016, MOVEMENT DISORD, V31, P53, DOI 10.1002/mds.26420
   Fischer CP, 2007, SCAND J MED SCI SPOR, V17, P580, DOI 10.1111/j.1600-0838.2006.00602.x
   Fisher BE, 2008, ARCH PHYS MED REHAB, V89, P1221, DOI 10.1016/j.apmr.2008.01.013
   Fisher BE, 2013, NEUROREPORT, V24, P509, DOI 10.1097/WNR.0b013e328361dc13
   Fletcher E, 2012, BMC HEALTH SERV RES, V12, DOI 10.1186/1472-6963-12-426
   Foltynie T, 2014, ALZHEIMERS DEMENT, V10, pS38, DOI 10.1016/j.jalz.2013.12.005
   Frazzitta G, 2015, NEUROREHAB NEURAL RE, V29, P123, DOI 10.1177/1545968314542981
   Frazzitta G, 2014, NEUROREHAB NEURAL RE, V28, P163, DOI 10.1177/1545968313508474
   Frigerio R, 2005, NEUROLOGY, V65, P1575, DOI 10.1212/01.wnl.0000184520.21744.a2
   Galassetti PR, 2006, J INVEST MED, V54, P67, DOI 10.2310/6650.2005.05024
   Gao X, 2012, ARCH NEUROL-CHICAGO, V69, P1381, DOI 10.1001/archneurol.2012.2032
   Gardner RC, 2015, ANN NEUROL, V77, P987, DOI 10.1002/ana.24396
   Golbidi S, 2014, J DIABETES RES, V2014, DOI 10.1155/2014/726861
   Golbidi S, 2012, OXID MED CELL LONGEV, V2012, DOI 10.1155/2012/349710
   Golbidi S, 2012, EXP DIABETES RES, DOI 10.1155/2012/941868
   Gordon B, 2014, CURR SPORT MED REP, V13, P253, DOI 10.1249/JSR.0000000000000073
   Gorelick PB, 1999, JAMA-J AM MED ASSOC, V281, P1112, DOI 10.1001/jama.281.12.1112
   Haavik J, 1998, MOL NEUROBIOL, V16, P285, DOI 10.1007/BF02741387
   Henderson GC, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00162
   Hernán MA, 2002, ANN NEUROL, V52, P276, DOI 10.1002/ana.10277
   Hu FB, 2004, NEW ENGL J MED, V351, P2694, DOI 10.1056/NEJMoa042135
   Hu G, 2006, NEUROLOGY, V67, P1955, DOI 10.1212/01.wnl.0000247052.18422.e5
   Hu G, 2007, DIABETES CARE, V30, P842, DOI 10.2337/dc06-2011
   Hwang Onyou, 2013, Exp Neurobiol, V22, P11, DOI 10.5607/en.2013.22.1.11
   Katz M, 2015, PARKINSONISM RELAT D, V21, P500, DOI 10.1016/j.parkreldis.2015.02.020
   Keshavarzian A, 2015, MOVEMENT DISORD, V30, P1351, DOI 10.1002/mds.26307
   LAKKA TA, 1994, NEW ENGL J MED, V330, P1549, DOI 10.1056/NEJM199406023302201
   Lang AE, 1998, NEW ENGL J MED, V339, P1044, DOI 10.1056/NEJM199810083391506
   Larson EB, 2006, ANN INTERN MED, V144, P73, DOI 10.7326/0003-4819-144-2-200601170-00004
   Li FZ, 2015, PREV CHRONIC DIS, V12, DOI 10.5888/pcd12.140413
   Li FZ, 2012, NEW ENGL J MED, V366, P511, DOI 10.1056/NEJMoa1107911
   Liu W, 2015, NEUROSCIENCE, V303, P42, DOI 10.1016/j.neuroscience.2015.06.054
   Logroscino G, 2006, J NEUROL NEUROSUR PS, V77, P1318, DOI 10.1136/jnnp.2006.097170
   Maher P, 2005, AGEING RES REV, V4, P288, DOI 10.1016/j.arr.2005.02.005
   Mehrholz J, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007830.pub4
   Monteiro RS, 2015, MED HYPOTHESES, V85, P537, DOI 10.1016/j.mehy.2015.07.011
   MOROO I, 1994, ACTA NEUROPATHOL, V87, P343
   Naci H, 2013, BMJ-BRIT MED J, V347, DOI 10.1136/bmj.f5577
   Okubo H, 2012, EUR J NEUROL, V19, P681, DOI 10.1111/j.1468-1331.2011.03600.x
   PAFFENBARGER RS, 1986, NEW ENGL J MED, V314, P605, DOI 10.1056/NEJM198603063141003
   Paillard T, 2015, J CLIN NEUROL, V11, P212, DOI 10.3988/jcn.2015.11.3.212
   Palacios N, 2011, MOVEMENT DISORD, V26, P2253, DOI 10.1002/mds.23855
   Paoli A, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/474296
   Park M, 2005, NEUROLOGY, V64, P1047, DOI 10.1212/01.WNL.0000154532.98495.BF
   Patki G, 2011, NEUROSCI LETT, V505, P268, DOI 10.1016/j.neulet.2011.10.036
   Pattyn N, 2013, SPORTS MED, V43, P121, DOI 10.1007/s40279-012-0003-z
   Pedersen BK, 2006, SCAND J MED SCI SPOR, V16, P3, DOI 10.1111/j.1600-0838.2006.00520.x
   Perry T, 2002, J PHARMACOL EXP THER, V302, P881, DOI 10.1124/jpet.102.037481
   Petzinger GM, 2007, J NEUROSCI, V27, P5291, DOI 10.1523/JNEUROSCI.1069-07.2007
   Poulton NP, 2005, EXP NEUROL, V193, P181, DOI 10.1016/j.expneurol.2004.12.006
   Pressley JC, 2003, NEUROLOGY, V60, P87, DOI 10.1212/WNL.60.1.87
   Radak Z, 2008, FREE RADICAL BIO MED, V44, P153, DOI 10.1016/j.freeradbiomed.2007.01.029
   Rotermund C, 2014, J NEUROCHEM, V131, P848, DOI 10.1111/jnc.12813
   Sääksjärvi K, 2014, EUR J EPIDEMIOL, V29, P285, DOI 10.1007/s10654-014-9887-2
   SANDYK R, 1992, INT J NEUROSCI, V64, P209, DOI 10.3109/00207459209000547
   Santiago JA, 2014, NEUROBIOL DIS, V72, P84, DOI 10.1016/j.nbd.2014.03.019
   SASCO AJ, 1992, ARCH NEUROL-CHICAGO, V49, P360, DOI 10.1001/archneur.1992.00530280040020
   Scalzo P, 2010, J NEUROL, V257, P540, DOI 10.1007/s00415-009-5357-2
   Schwarzschild MA, 2014, JAMA NEUROL, V71, P141, DOI 10.1001/jamaneurol.2013.5528
   Sharp K, 2014, NEUROSCI BIOBEHAV R, V47, P445, DOI 10.1016/j.neubiorev.2014.09.009
   Shih IF, 2016, PARKINSONISM RELAT D, V28, P112, DOI 10.1016/j.parkreldis.2016.05.007
   Simuni T, 2013, MOVEMENT DISORD, V28, P1823, DOI 10.1002/mds.25639
   Takahashi M, 1996, NEUROSCI LETT, V204, P201, DOI 10.1016/0304-3940(96)12357-0
   Tanner CM, 2014, ALZHEIMERS DEMENT, V10, pS213, DOI 10.1016/j.jalz.2014.04.014
   TANNER CM, 1989, TRENDS NEUROSCI, V12, P49, DOI 10.1016/0166-2236(89)90135-5
   Tanner CM, 1996, NEUROL CLIN, V14, P317, DOI 10.1016/S0733-8619(05)70259-0
   Thacker EL, 2008, MOVEMENT DISORD, V23, P69, DOI 10.1002/mds.21772
   Tian T, 2015, MED HYPOTHESES, V85, P397, DOI 10.1016/j.mehy.2015.06.016
   Tillerson JL, 2003, NEUROSCIENCE, V119, P899, DOI 10.1016/S0306-4522(03)00096-4
   Tillerson JL, 2002, J NEUROSCI, V22, P6790
   Tillerson JL, 2001, J NEUROSCI, V21, P4427, DOI 10.1523/JNEUROSCI.21-12-04427.2001
   Tomlinson CL, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002817.pub4
   Tsou YH, 2015, EXP NEUROL, V263, P50, DOI 10.1016/j.expneurol.2014.09.021
   UNGER JW, 1991, PROG NEUROBIOL, V36, P343, DOI 10.1016/0301-0082(91)90015-S
   van Nimwegen M, 2011, J NEUROL, V258, P2214, DOI 10.1007/s00415-011-6097-7
   VanLeeuwen JE, 2010, J NEUROSCI RES, V88, P650, DOI 10.1002/jnr.22216
   Wang YL, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0131778
   Weinreb O, 2013, FREE RADICAL BIO MED, V62, P52, DOI 10.1016/j.freeradbiomed.2013.01.017
   Weisskopf MG, 2007, AM J EPIDEMIOL, V166, P561, DOI 10.1093/aje/kwm127
   Welty FK, 2016, TRANSL RES, V167, P257, DOI 10.1016/j.trsl.2015.06.017
   Wessel TR, 2004, JAMA-J AM MED ASSOC, V292, P1179, DOI 10.1001/jama.292.10.1179
   Winklhofer KF, 2010, BBA-MOL BASIS DIS, V1802, P29, DOI 10.1016/j.bbadis.2009.08.013
   Xu Q, 2010, NEUROLOGY, V75, P341, DOI 10.1212/WNL.0b013e3181ea1597
   Xu Q, 2011, DIABETES CARE, V34, P910, DOI 10.2337/dc10-1922
   Yaffe K, 2001, ARCH INTERN MED, V161, P1703, DOI 10.1001/archinte.161.14.1703
   Yamaoka K, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-138
   Yang F, 2015, BRAIN, V138, P269, DOI 10.1093/brain/awu323
   Zhang P, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/729194
   Zoladz JA, 2014, J PHYSIOL PHARMACOL, V65, P441
   Zoladz JA, 2008, J PHYSIOL PHARMACOL, V59, P119
NR 118
TC 89
Z9 99
U1 3
U2 40
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-3185
EI 1531-8257
J9 MOVEMENT DISORD
JI Mov. Disord.
PD OCT
PY 2016
VL 31
IS 10
BP 1444
EP 1454
DI 10.1002/mds.26728
PG 11
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA DZ7MG
UT WOS:000386049400003
PM 27477046
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Martinelli, N
   Girelli, D
   Olivieri, O
   Cavallari, U
   Biscuola, M
   Trabetti, E
   Friso, S
   Pizzolo, F
   Tenuti, I
   Bozzini, C
   Villa, G
   Ceradini, B
   Sandri, M
   Cheng, S
   Grow, MA
   Pignatti, PF
   Corrocher, R
AF Martinelli, N
   Girelli, D
   Olivieri, O
   Cavallari, U
   Biscuola, M
   Trabetti, E
   Friso, S
   Pizzolo, F
   Tenuti, I
   Bozzini, C
   Villa, G
   Ceradini, B
   Sandri, M
   Cheng, S
   Grow, MA
   Pignatti, PF
   Corrocher, R
TI Interaction between metabolic syndrome and PON1 polymorphisms as a
   determinant of the risk of coronary artery disease
SO CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE PON1 polymorphisms; metabolic syndrome; coronary artery disease
ID HUMAN PARAOXONASE GENE; LOW-DENSITY-LIPOPROTEIN; HOMEOSTASIS MODEL
   ASSESSMENT; SERUM PARAOXONASE; MYOCARDIAL-INFARCTION; HEART-DISEASE;
   GLN-ARG192 POLYMORPHISM; CARDIOVASCULAR-DISEASE; OXIDATIVE MODIFICATION;
   HUMPONA GENE
AB The enzyme serum paraoxonase plays an important role in antioxidant defences and prevention of atherosclerosis. Metabolic syndrome (MS) is a clinical condition associated with increased oxidant stress and cardiovascular mortality. Two common polymorphisms of serum paraoxonase, PON1 Leu(55)Met and Gln(192)Arg, have been postulated to modulate the cardiovascular risk. We studied 915 subjects with angiographic documentation: 642 subjects with coronary atherosclerosis and 273 with normal coronary arteries. Two hundred and twenty-four subjects met the diagnostic criteria of MS. We found a significant interaction between MS and both the PON1 polymorphisms in determining the risk of coronary artery disease (P < 0.05 by likelihood-ratio test). The 55Leu and the 192Arg alleles, associated with reduced protection against lipid peroxidation, were associated with coronary artery disease only in the MS subgroup. Subjects with MS and both 55Leu and 192Arg alleles had significantly increased risk (OR=9.38 with 95% CI=3.02-29.13 after adjustment by multiple logistic regression) as compared to subjects without MS and with 55Met/Met-192Gln/Gln genotype. No increased risk was found for subjects with MS and the 55Met/Met-192Gln/Gln genotype. This study highlights a potential example of genetic (paraoxonase polymorphisms)-clinical (MS) interaction influencing cardiovascular risk.
C1 Univ Verona, Dept Clin & Expt Med, Policlin GB Rossi, I-37134 Verona, Italy.
   Univ Verona, Dept Mother & Child & Biol Genet, Sect Biol & Genet, I-37100 Verona, Italy.
   Roche Mol Syst Inc, Dept Human Genet, Alameda, CA USA.
C3 University of Verona; Azienda Ospedaliera Universitaria Integrata
   Verona; University of Verona; Roche Holding; Roche Holding USA
RP Univ Verona, Dept Clin & Expt Med, Policlin GB Rossi, I-37134 Verona, Italy.
EM roberto.corrocher@univr.it
RI Girelli, Domenico/B-1183-2008; Friso, Simonetta/K-4715-2016; Vicente,
   Jose/C-1123-2011; Pizzolo, Francesca/AAF-6581-2020; Olivieri,
   Oliviero/A-9126-2008; Sandri, Marco/L-2875-2013; Martinelli,
   Nicola/J-5622-2016
OI Cavallari, Ugo/0000-0002-3395-4033; Sandri, Marco/0000-0002-1422-5695;
   GIRELLI, Domenico/0000-0001-9684-1899; Martinelli,
   Nicola/0000-0001-6465-5119; olivieri, oliviero/0000-0001-8209-9056
CR Antikainen M, 1996, J CLIN INVEST, V98, P883, DOI 10.1172/JCI118869
   Arca M, 2002, EUR J CLIN INVEST, V32, P9, DOI 10.1046/j.1365-2362.2002.00935.x
   Aubó C, 2000, EUR HEART J, V21, P33, DOI 10.1053/euhj.1999.1660
   Aviram M, 1999, MOL MED TODAY, V5, P381, DOI 10.1016/S1357-4310(99)01546-4
   Aviram M, 1998, J CLIN INVEST, V101, P1581, DOI 10.1172/JCI1649
   Aynacioglu AS, 2000, INT J CARDIOL, V74, P33, DOI 10.1016/S0167-5273(00)00242-4
   Barbieri M, 2002, J CLIN ENDOCR METAB, V87, P222, DOI 10.1210/jc.87.1.222
   Bozzini C, 2002, CLIN CHEM, V48, P622
   Cascorbi I, 1999, PHARMACOGENETICS, V9, P755, DOI 10.1097/00008571-199912000-00010
   Chen Q, 2003, AM J HUM GENET, V72, P13, DOI 10.1086/345312
   Cheng S, 1999, GENOME RES, V9, P936, DOI 10.1101/gr.9.10.936
   Christiansen L, 2004, EUR J HUM GENET, V12, P843, DOI 10.1038/sj.ejhg.5201235
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Deakin SP, 2004, CLIN SCI, V107, P435, DOI 10.1042/CS20040187
   Draganov DI, 2000, J BIOL CHEM, V275, P33435, DOI 10.1074/jbc.M004543200
   Durrington PN, 2001, ARTERIOSCL THROM VAS, V21, P473, DOI 10.1161/01.ATV.21.4.473
   Ferré N, 2002, CLIN BIOCHEM, V35, P197, DOI 10.1016/S0009-9120(02)00295-3
   Ferretti G, 2004, J CLIN ENDOCR METAB, V89, P2957, DOI 10.1210/jc.2003-031897
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Garin MCB, 1997, J CLIN INVEST, V99, P62, DOI 10.1172/JCI119134
   Getz GS, 2004, CURR OPIN LIPIDOL, V15, P261, DOI 10.1097/00041433-200406000-00005
   Girelli D, 2000, NEW ENGL J MED, V343, P774, DOI 10.1056/NEJM200009143431104
   Harel M, 2004, NAT STRUCT MOL BIOL, V11, P412, DOI 10.1038/nsmb767
   Hasselwander O, 1999, KIDNEY INT, V56, P289, DOI 10.1046/j.1523-1755.1999.00521.x
   Heijmans BT, 2000, ATHEROSCLEROSIS, V149, P91, DOI 10.1016/S0021-9150(99)00311-1
   Herrmann SM, 1996, ATHEROSCLEROSIS, V126, P299, DOI 10.1016/0021-9150(96)05917-5
   HUMBERT R, 1993, NAT GENET, V3, P73, DOI 10.1038/ng0193-73
   Imai Y, 2000, ATHEROSCLEROSIS, V149, P435, DOI 10.1016/S0021-9150(99)00340-8
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jarvik GP, 2000, ARTERIOSCL THROM VAS, V20, P2441, DOI 10.1161/01.ATV.20.11.2441
   Kakafika AI, 2003, J LIPID RES, V44, P1919, DOI 10.1194/jlr.M300129-JLR200
   Ko YL, 1998, ATHEROSCLEROSIS, V141, P259, DOI 10.1016/S0021-9150(98)00179-8
   Letellier C, 2002, DIABETES METAB, V28, P297
   Li JP, 2005, GENET MED, V7, P58, DOI 10.1097/01.GIM.0000151152.78092.CA
   Lusis AJ, 2000, NATURE, V407, P233, DOI 10.1038/35025203
   Mackness B, 1999, LANCET, V353, P468, DOI 10.1016/S0140-6736(98)05105-8
   Mackness B, 2001, ARTERIOSCL THROM VAS, V21, P1451, DOI 10.1161/hq0901.094247
   MACKNESS MI, 1993, ATHEROSCLEROSIS, V104, P129, DOI 10.1016/0021-9150(93)90183-U
   Malin R, 2001, FREE RADICAL RES, V34, P477, DOI 10.1080/10715760100300421
   Martinelli N, 2004, EUR J CLIN INVEST, V34, P14, DOI 10.1111/j.1365-2362.2004.01292.x
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mochizuki H, 1998, GENE, V213, P149, DOI 10.1016/S0378-1119(98)00193-0
   Ng CJ, 2005, FREE RADICAL BIO MED, V38, P153, DOI 10.1016/j.freeradbiomed.2004.09.035
   Ng CJ, 2001, J BIOL CHEM, V276, P44444, DOI 10.1074/jbc.M105660200
   Odawara M, 1997, J CLIN ENDOCR METAB, V82, P2257, DOI 10.1210/jc.82.7.2257
   Olivieri O, 2003, J LIPID RES, V44, P2374, DOI 10.1194/jlr.M300253-JLR200
   Ombres D, 1998, ARTERIOSCL THROM VAS, V18, P1611, DOI 10.1161/01.ATV.18.10.1611
   Osei-Hyiaman D, 2001, EUR J ENDOCRINOL, V144, P639, DOI 10.1530/eje.0.1440639
   Pati N, 1998, INT J CARDIOL, V66, P165, DOI 10.1016/S0167-5273(98)00209-5
   Pfohl M, 1999, DIABETES, V48, P623, DOI 10.2337/diabetes.48.3.623
   PrimoParmo SL, 1996, GENOMICS, V33, P498, DOI 10.1006/geno.1996.0225
   Rea IM, 2004, EXP GERONTOL, V39, P629, DOI 10.1016/j.exger.2003.11.019
   Reaven G, 2002, CIRCULATION, V106, P286, DOI 10.1161/01.CIR.0000019884.36724.D9
   Rice GI, 1997, CORONARY ARTERY DIS, V8, P677, DOI 10.1097/00019501-199711000-00001
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   RUIZ J, 1995, LANCET, V346, P869, DOI 10.1016/S0140-6736(95)92709-3
   Sanghera DK, 1997, ARTERIOSCL THROM VAS, V17, P1067, DOI 10.1161/01.ATV.17.6.1067
   Sanghera DK, 1998, AM J HUM GENET, V62, P36, DOI 10.1086/301669
   Sen-Banerjee S, 2000, ARTERIOSCL THROM VAS, V20, P2120, DOI 10.1161/01.ATV.20.9.2120
   Sentí M, 2003, J CLIN ENDOCR METAB, V88, P5422, DOI 10.1210/jc.2003-030648
   Serrato M, 1995, J CLIN INVEST, V96, P3005, DOI 10.1172/JCI118373
   Shih DM, 1998, NATURE, V394, P284, DOI 10.1038/28406
   Suehiro T, 1996, INT J CARDIOL, V57, P69, DOI 10.1016/S0167-5273(96)02779-9
   Tomás M, 2002, J LIPID RES, V43, P713
   Turban S, 2001, ATHEROSCLEROSIS, V154, P633, DOI 10.1016/S0021-9150(00)00495-0
   Tward A, 2002, CIRCULATION, V106, P484, DOI 10.1161/01.CIR.0000023623.87083.4F
   Watzinger N, 2002, CARDIOLOGY, V98, P116, DOI 10.1159/000066321
   Wheeler JG, 2004, LANCET, V363, P689, DOI 10.1016/S0140-6736(04)15642-0
   Zama T, 1997, ARTERIOSCL THROM VAS, V17, P3565, DOI 10.1161/01.ATV.17.12.3565
NR 69
TC 29
Z9 31
U1 0
U2 2
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1591-8890
EI 1591-9528
J9 CLIN EXP MED
JI Clin. Exper. Med.
PD MAY
PY 2005
VL 5
IS 1
BP 20
EP 30
DI 10.1007/s10238-005-0060-9
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 931UO
UT WOS:000229511200003
PM 15928879
DA 2025-06-11
ER

PT J
AU Ciocca, G
   Carosa, E
   Stornelli, M
   Limoncin, E
   Gravina, GL
   Iannarelli, R
   Sperandio, A
   Di Sante, S
   Lenzi, A
   Lauro, D
   Jannini, EA
AF Ciocca, Giacomo
   Carosa, Eleonora
   Stornelli, Maria
   Limoncin, Erika
   Gravina, Giovanni L.
   Iannarelli, Rossella
   Sperandio, Alessandra
   Di Sante, Stefania
   Lenzi, Andrea
   Lauro, Davide
   Jannini, Emmanuele A.
TI Post-traumatic stress disorder, coping strategies and type 2 diabetes:
   psychometric assessment after L'Aquila earthquake
SO ACTA DIABETOLOGICA
LA English
DT Article
DE PTSD; Coping strategies; Type 2 diabetes; Earthquake; Psychometric
   assessment
ID DSM-IV-TR; METABOLIC SYNDROME; BRIEF COPE; DEPRESSIVE SYMPTOMS; PTSD
   PREVALENCE; MENTAL-HEALTH; SURVIVORS; VULNERABILITY; VETERANS; ILLNESS
AB After natural and collective catastrophes, many behavioral phenomena can occur through psychobiological responses that involve also the diabetic condition.The aim of this study was to investigate post-traumatic stress disorder (PTSD) and coping strategies in type 2 diabetic patients after L'Aquila earthquake, with a particular attention to the newly diagnosed patients and to the gender differences.
   Among the local diabetic population, we recruited 100 diabetic patients (46 women and 54 men). Sixty of these had diabetes before the earthquake (pre-quake patients), and other 40 received diabetes diagnosis after the earthquake (post-quake patients). A psychometric protocol composed by Davidson Trauma Scale for PTSD and Brief-COPE for coping strategies was administered.
   We found significant differences in the levels of PTSD when comparing both post-quake with pre-quake patients (post-quake = 51.72 +/- A 26.05 vs. pre-quake = 31.65 +/- A 22.59; p < 0.05) and the female patients with males (women = 53.50 +/- A 27.01 vs. men = 31.65 +/- A 23.06; p < 0.05) and also in the prevalence [post-quake = 27/40 (67.5 %) vs. pre-quake = 20/60 (33.3 %); p < 0.05], [women = 27/46 (58.69 %) vs. men = 16/54 (29.62 %); p < 0.05]. Moreover, maladaptive coping was a predictive factor for PTSD in the post-quake group only (OR 1.682; 95 % CI 1.155-2.450; p = 0.006).
   Our results revealed that PTSD may be considered an important comorbidity factor in newly diagnosed patients and in diabetic women. Hence, a psychological support seems particularly important in these patients after a collective traumatic event to help them react to both PTSD and diabetes and to help them improve their coping skills.
C1 [Ciocca, Giacomo; Carosa, Eleonora; Stornelli, Maria; Limoncin, Erika; Gravina, Giovanni L.] Univ Aquila, Dept Biotechnol & Appl Clin Sci, I-67100 Laquila, Italy.
   [Iannarelli, Rossella; Sperandio, Alessandra] San Salvatore Hosp, Unit Diabetol & Metab Dis, Laquila, Italy.
   [Di Sante, Stefania; Lenzi, Andrea] Univ Roma La Sapienza, Dept Expt Med, I-00185 Rome, Italy.
   [Lauro, Davide; Jannini, Emmanuele A.] Univ Roma Tor Vergata, Dept Syst Med, I-00131 Rome, Italy.
C3 University of L'Aquila; Sapienza University Rome; University of Rome Tor
   Vergata
RP Jannini, EA (corresponding author), Univ Roma Tor Vergata, Dept Syst Med, Via Montpellier 1, I-00131 Rome, Italy.
EM eajannini@gmail.com
RI Limoncin, Erika/IQX-0012-2023; Lenzi, Andrea/I-7711-2015
OI CAROSA, Eleonora/0000-0002-6593-6833; Lauro, Davide/0000-0002-8597-4415;
   Lenzi, Andrea/0000-0002-7711-0465; Gravina, Giovanni
   Luca/0000-0002-6797-8324; Jannini, Emmanuele A./0000-0002-5874-039X
FU Italian Ministry of University (MIUR-PRIN Grant); Italian Ministry of
   University (MIUR-FIRB Grant)
FX Authors receive the fund from Italian Ministry of University (MIUR-PRIN
   and FIRB Grants).
CR Agyemang C, 2012, EUR J PUBLIC HEALTH, V22, P658, DOI 10.1093/eurpub/ckr138
   Anagnostis P, 2009, J CLIN ENDOCR METAB, V94, P2692, DOI 10.1210/jc.2009-0370
   APA A.P. A., 2000, Diagnostic and statistical manual of mental disorders: DSM-IV, V4th
   Arikan G, 2012, J TRAUMA DISSOCIATIO, V13, P209, DOI 10.1080/15299732.2012.642746
   Bartoli F, 2013, METAB SYNDR RELAT D, V11, P301, DOI 10.1089/met.2013.0010
   Benítez CIP, 2013, INT J PSYCHIAT CLIN, V17, P232, DOI 10.3109/13651501.2012.667113
   Boscarino JA, 2004, ANN NY ACAD SCI, V1032, P141, DOI 10.1196/annals.1314.011
   Boyko EJ, 2010, DIABETES CARE, V33, P1771, DOI 10.2337/dc10-0296
   Bryant RA, 2003, CNS SPECTRUMS, V8, P668, DOI 10.1017/S1092852900008853
   Carmassi C, 2014, J AFFECT DISORDERS, V160, P55, DOI 10.1016/j.jad.2014.02.028
   Carmassi C, 2013, J AFFECT DISORDERS, V151, P843, DOI 10.1016/j.jad.2013.07.020
   Carta G, 2012, J MATERN-FETAL NEO M, V25, P2411, DOI 10.3109/14767058.2012.697945
   Carver CS, 1997, INT J BEHAV MED, V4, P92, DOI 10.1207/s15327558ijbm0401_6
   CARVER CS, 1989, J PERS SOC PSYCHOL, V56, P267, DOI 10.1037/0022-3514.56.2.267
   Ceretta LB, 2012, ACTA DIABETOL, V49, pS227, DOI 10.1007/s00592-012-0435-9
   Charney DS, 2004, AM J PSYCHIAT, V161, P195, DOI 10.1176/appi.ajp.161.2.195
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   Davidson JRT, 1997, PSYCHOL MED, V27, P153, DOI 10.1017/S0033291796004229
   Dell'Osso L, 2011, J AFFECT DISORDERS, V131, P79, DOI 10.1016/j.jad.2010.11.023
   Dell'Osso L, 2013, J AFFECT DISORDERS, V146, P174, DOI 10.1016/j.jad.2012.08.048
   Dell'Osso L, 2011, J AFFECT DISORDERS, V134, P59, DOI 10.1016/j.jad.2011.06.025
   Ditlevsen DN, 2012, ANN GEN PSYCHIATR, V11, DOI 10.1186/1744-859X-11-26
   Feder A, 2013, J AFFECT DISORDERS, V147, P156, DOI 10.1016/j.jad.2012.10.027
   Furuya M, 2013, ACTA DIABETOL, V50, P117, DOI 10.1007/s00592-010-0219-z
   Gendelman N, 2009, DIABETES CARE, V32, P575, DOI 10.2337/dc08-1835
   Gigantesco A, 2013, J AFFECT DISORDERS, V148, P265, DOI 10.1016/j.jad.2012.12.006
   Gois Carlos, 2012, BMC Res Notes, V5, P271, DOI 10.1186/1756-0500-5-271
   Goodwin RD, 2005, PREV MED, V40, P570, DOI 10.1016/j.ypmed.2004.07.013
   Heppner PS, 2009, BMC MED, V7, DOI 10.1186/1741-7015-7-1
   Kamoi K, 2006, ENDOCR J, V53, P511, DOI 10.1507/endocrj.K06-022
   Laryea G, 2012, BEHAV SCI-BASEL, V2, P135, DOI 10.3390/bs2020135
   LAZARUS RS, 1993, PSYCHOSOM MED, V55, P234, DOI 10.1097/00006842-199305000-00002
   Lukaschek K, 2013, J PSYCHOSOM RES, V74, P340, DOI 10.1016/j.jpsychores.2012.12.011
   Marcovecchio ML, 2012, SCI SIGNAL, V5, DOI 10.1126/scisignal.2003508
   Meyer B, 2001, J PSYCHOPATHOL BEHAV, V23, P265, DOI 10.1023/A:1012731520781
   Neria Y, 2008, PSYCHOL MED, V38, P467, DOI 10.1017/S0033291707001353
   Nishina M, 2011, J ATHEROSCLER THROMB, V18, P396, DOI 10.5551/jat.6692
   Oflaz F, 2008, J CLIN NURS, V17, P677, DOI 10.1111/j.1365-2702.2007.02047.x
   Rotella F, 2012, ACTA DIABETOL, V49, pS179, DOI 10.1007/s00592-012-0403-4
   Roy T, 2012, J AFFECT DISORDERS, V142, pS8, DOI 10.1016/S0165-0327(12)70004-6
   Sanita ISd, 2013, 132 ISTISAN
   Sherin Jonathan E, 2011, Dialogues Clin Neurosci, V13, P263
   Stratta P, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f3179
   Stratta P, 2012, ANN I SUPER SANITA, V48, P132, DOI 10.4415/ANN_12_02_05
   Taylor R, 2013, DIABETES CARE, V36, P1047, DOI 10.2337/dc12-1805
   Trento M, 2012, ACTA DIABETOL, V49, P199, DOI 10.1007/s00592-011-0275-z
   Trief PM, 2006, J BEHAV MED, V29, P411, DOI 10.1007/s10865-006-9067-2
   Trief PM, 2006, DIABETES CARE, V29, P830, DOI 10.2337/diacare.29.04.06.dc05-1769
   Zetsche U, 2009, J BEHAV THER EXP PSY, V40, P499, DOI 10.1016/j.jbtep.2009.07.001
NR 49
TC 23
Z9 24
U1 0
U2 3
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD JUN
PY 2015
VL 52
IS 3
BP 513
EP 521
DI 10.1007/s00592-014-0686-8
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA CJ1HB
UT WOS:000355233500011
PM 25408297
DA 2025-06-11
ER

PT J
AU Mallah, MA
   Soomro, T
   Noreen, S
   Ali, M
   Kafle, A
   Khatoon, N
   Naveed, M
AF Mallah, Manthar Ali
   Soomro, Tahmina
   Noreen, Sobia
   Ali, Mukhtiar
   Kafle, Akriti
   Khatoon, Nafeesa
   Naveed, Muhammad
TI Association of obesity and cardiovascular disease and progress in
   pharmacotherapy: what is next for obesity?
SO INTERNATIONAL JOURNAL OF REHABILITATION RESEARCH
LA English
DT Review
DE BMI; cardiovascular diseases; depression; hypertension; lipids; obesity;
   obesity paradox
ID BODY-MASS INDEX; CORONARY-ARTERY-DISEASE; ALL-CAUSE MORTALITY;
   DENSITY-LIPOPROTEIN CHOLESTEROL; DIETARY ENERGY DENSITY;
   LEFT-VENTRICULAR MASS; C-REACTIVE PROTEIN; ATRIAL-FIBRILLATION;
   ADIPOSE-TISSUE; METABOLIC SYNDROME
AB Obesity has recently emerged as one of the most severe health concerns. Obesity is a key autonomous risk factor for heart failure and contributes to cardiovascular disease (CVD) risk factors such as hypertension, type 2 diabetes, and metabolic abnormalities. Obesity is caused by a metabolic imbalance, which occurs when calories burnt are fewer than the number of calories consumed. There are several pathways accountable for the adverse impacts of obesity on the cardiovascular system. Inflammatory cell infiltration develops in the adipose tissue, the pancreas, and other issues similar to the progression of obesity. Inflammation is triggered by immune cells that invade dysfunctional adipose tissue. The atherosclerotic inflammation phase, related to obesity, induces coronary calcification. Obesity is linked to elevated levels of leptin and high blood pressure. Leptin causes systemic vasoconstriction, sodium retention, and increased blood pressure by influencing the synthesis of nitric oxide and activating the sympathetic nervous system. Obesity is a well-known risk factor for CVD and is one of the leading causes of the greater risk of diseases, including dyslipidemia, hypertension, depression, metabolic syndrome, atrial fibrillation, and heart failure in adults and children. When used with dietary improvements, antiobesity drugs improve the probability of experiencing clinically healthy (5%) weight loss. This review aimed to address the consequences of obesity on cardiac structure and function, risk factors, the impact of the obesity paradox, pharmacological treatment strategies for managing and recommended exercise and diet.
C1 [Mallah, Manthar Ali; Khatoon, Nafeesa] Zhengzhou Univ, Coll Publ Hlth, Zhengzhou, Peoples R China.
   [Soomro, Tahmina] Shah Abdul Latif Univ, Dept Sociol, Khairpur, Pakistan.
   [Noreen, Sobia] Islamia Univ Bahawalpur, Fac Pharm, Dept Pharmaceut, Bahawalpur, Pakistan.
   [Ali, Mukhtiar] Quaid Eawam Univ Engn Sci & Technol, Dept Chem Engn, Nawabshah, Pakistan.
   [Kafle, Akriti] Zhengzhou Univ, Coll Publ Hlth, Nursing Sch, Zhengzhou, Peoples R China.
   [Naveed, Muhammad] Nanjing Med Univ, Sch Pharm, Dept Clin Pharm, Nanjing, Peoples R China.
   [Mallah, Manthar Ali] Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Peoples R China.
C3 Zhengzhou University; Shah Abdul Latif University; Islamia University of
   Bahawalpur; Zhengzhou University; Nanjing Medical University; Zhengzhou
   University
RP Mallah, MA (corresponding author), Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Peoples R China.
EM mantharmallah@gmail.com
RI Noreen, Sobia/AAT-8296-2021; Naveed, Muhammad/Y-3856-2018; Mallah,
   Manthar Ali/G-6292-2019
OI Naveed, Muhammad/0000-0002-2193-9266; Noreen, Sobia/0000-0002-4407-6002;
   Mallah, Manthar Ali/0000-0003-1037-9440; Khatoon,
   Nafeesa/0009-0006-1892-4537
CR Abed HS, 2013, HEART RHYTHM, V10, P90, DOI 10.1016/j.hrthm.2012.08.043
   Achari AE, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18061321
   Akil L, 2011, J HEALTH CARE POOR U, V22, P61, DOI 10.1353/hpu.2011.0166
   Al-Assal K., 2018, Clinical Nutrition Experimental, V20, P60, DOI 10.1016/j.yclnex.2018.03.001
   Al-Shehri F., 2016, Saudi Journal of Obesity, V4, P25, DOI [DOI 10.4103/2347-2618.184970, 10.4103/2347-2618.184970]
   Alexander JK, 1998, HEART AND LUNG IN OBESITY, P45
   Alpert MA, 2001, AM J MED SCI, V321, P225, DOI 10.1097/00000441-200104000-00003
   ALPERT MA, 1995, AM J CARDIOL, V76, P1194, DOI 10.1016/S0002-9149(99)80338-5
   Alpert MA, 2014, TRANSL RES, V164, P345, DOI 10.1016/j.trsl.2014.04.010
   ANDERSON KM, 1987, JAMA-J AM MED ASSOC, V257, P2176, DOI 10.1001/jama.257.16.2176
   Antoniades C, 2019, J CARDIOVASC COMPUT, V13, P288, DOI 10.1016/j.jcct.2019.03.006
   Aprahamian TR, 2011, INT J INFLAMM, V2011, DOI 10.4061/2011/376909
   Artero EG, 2011, J AM COLL CARDIOL, V57, P1831, DOI 10.1016/j.jacc.2010.12.025
   Aune D, 2016, CIRCULATION, V133, P639, DOI 10.1161/CIRCULATIONAHA.115.016801
   Aurigemma GP, 2013, CIRC-CARDIOVASC IMAG, V6, P142, DOI 10.1161/CIRCIMAGING.111.964627
   Ballantyne C.M., 2014, Clinical Lipidology: A Companion to Braunwald's Heart Disease E -Book
   Balsan GA, 2015, REV ASSOC MED BRAS, V61, P72, DOI 10.1590/1806-9282.61.01.072
   Baptista de Faria G., 2016, CIRCULATION, V134, pA20159
   Barroso Taianah Almeida, 2017, Int. J. Cardiovasc. Sci., V30, P416
   BENJAMIN EJ, 1994, JAMA-J AM MED ASSOC, V271, P840, DOI 10.1001/jama.271.11.840
   Blaine B, 2008, J HEALTH PSYCHOL, V13, P1190, DOI 10.1177/1359105308095977
   Blair SN, 1996, JAMA-J AM MED ASSOC, V276, P205, DOI 10.1001/jama.276.3.205
   Bohula EA, 2018, AM HEART J, V202, P39, DOI 10.1016/j.ahj.2018.03.012
   Bornstein SR, 2006, MOL PSYCHIATR, V11, P892, DOI 10.1038/sj.mp.4001873
   Calori G, 2011, DIABETES CARE, V34, P210, DOI 10.2337/dc10-0665
   Carbone S, 2019, VASC HEALTH RISK MAN, V15, P89, DOI 10.2147/VHRM.S168946
   Castro AM., 2017, Revista Medica del Hospital General de Mexico, V80, P101, DOI [10.1016/j.hgmx.2016.06, DOI 10.1016/J.HGMX.2016.06]
   Charlson FJ, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-47
   Cinti S, 2005, J LIPID RES, V46, P2347, DOI 10.1194/jlr.M500294-JLR200
   Clark DM, 1997, J AM COLL CARDIOL, V30, P1039, DOI 10.1016/S0735-1097(97)00254-4
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Coutinho T, 2013, J AM COLL CARDIOL, V61, P553, DOI 10.1016/j.jacc.2012.10.035
   Coutinho T, 2011, J AM COLL CARDIOL, V57, P1877, DOI 10.1016/j.jacc.2010.11.058
   Cui YD, 2001, ARCH INTERN MED, V161, P1413, DOI 10.1001/archinte.161.11.1413
   Cullen P, 2000, AM J CARDIOL, V86, P943, DOI 10.1016/S0002-9149(00)01127-9
   Davies MJ, 2018, DIABETES OBES METAB, V20, P734, DOI 10.1111/dom.13125
   Davis Cindy D, 2016, Nutr Today, V51, P167, DOI 10.1097/NT.0000000000000167
   Carvalho Maria Helena C. de, 2006, Arq Bras Endocrinol Metab, V50, P304, DOI 10.1590/S0004-27302006000200016
   Drewnowski A, 2005, AM J CLIN NUTR, V82, p265S, DOI 10.1093/ajcn/82.1.265S
   Eckel R. H., 2014, Circulation, V129, pS76, DOI [10.1016/j.jacc.2013.11.003, 10.1161/01.cir.0000437740.48606.d1]
   Elderon L, 2013, PROG CARDIOVASC DIS, V55, P511, DOI 10.1016/j.pcad.2013.03.010
   Ernstsen L, 2016, AM J MED, V129, P82, DOI 10.1016/j.amjmed.2015.08.012
   Fan JY, 2013, INT J CARDIOL, V168, P4761, DOI 10.1016/j.ijcard.2013.07.230
   Faria AM, 2010, ARQ BRAS ENDOCRINOL, V54, P516, DOI 10.1590/S0004-27302010000600003
   Farr OM, 2016, DIABETOLOGIA, V59, P954, DOI 10.1007/s00125-016-3874-y
   Feingold KR, 2010, J LIPID RES, V51, P682, DOI 10.1194/jlr.E005454
   Feingold KR., 2020, Endotext
   Flegal KM, 2013, JAMA-J AM MED ASSOC, V309, P71, DOI 10.1001/jama.2012.113905
   Gandhi H., 2013, METABOLIC SYNDROME N, P297
   Gelber RP, 2007, AM J HYPERTENS, V20, P370, DOI 10.1016/j.amjhyper.2006.10.011
   Giannini DT, 2017, EUR J CLIN NUTR, V71, P1206, DOI 10.1038/ejcn.2017.74
   Gomes F, 2010, ARQ BRAS CARDIOL, V94, P273, DOI 10.1590/S0066-782X2010000200021
   Gordon S, 2003, NAT REV IMMUNOL, V3, P23, DOI 10.1038/nri978
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Grundy SM, 2004, CIRCULATION, V110, P227, DOI 10.1161/01.CIR.0000133317.49796.0E
   Guzik TJ, 2017, CARDIOVASC RES, V113, P1009, DOI 10.1093/cvr/cvx108
   Halverstadt A, 2007, METABOLISM, V56, P444, DOI 10.1016/j.metabol.2006.10.019
   Hatem SN, 2015, J AM COLL CARDIOL, V66, P12, DOI 10.1016/j.jacc.2015.04.057
   Hausman D B, 2001, Obes Rev, V2, P239, DOI 10.1046/j.1467-789X.2001.00042.x
   HIRSCH J, 1976, CLIN ENDOCRINOL META, V5, P299, DOI 10.1016/S0300-595X(76)80023-0
   HSUEH WA, 1994, ENDOCRIN METAB CLIN, V23, P405, DOI 10.1016/S0889-8529(18)30105-1
   Iscan S, 2017, ANATOL J CARDIOL, V17, DOI 10.14744/AnatolJCardiol.2017.7729
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jain Suyog S, 2011, Indian J Endocrinol Metab, V15, P99, DOI 10.4103/2230-8210.81938
   James WPT, 2010, NEW ENGL J MED, V363, P905, DOI 10.1056/NEJMoa1003114
   Joao AL, 2016, OBES REV, V17, P553, DOI 10.1111/obr.12421
   Kachur S, 2016, AM J MED, V129, P1316, DOI 10.1016/j.amjmed.2016.07.006
   Kaptoge S, 2010, LANCET, V375, P132, DOI 10.1016/S0140-6736(09)61717-7
   Katzmarzyk PT, 2005, DIABETES CARE, V28, P391, DOI 10.2337/diacare.28.2.391
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Keane KN, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/181643
   Knudsen LB, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00155
   Kushner RF, 2020, OBESITY, V28, P1050, DOI 10.1002/oby.22794
   Lara-Castro C, 2007, CURR OPIN LIPIDOL, V18, P263, DOI 10.1097/MOL.0b013e32814a645f
   LAUER MS, 1991, JAMA-J AM MED ASSOC, V266, P231, DOI 10.1001/jama.266.2.231
   Lavie CJ, 2016, CAN J CARDIOL, V32, pS365, DOI 10.1016/j.cjca.2016.07.508
   Lavie CJ, 2016, PROG CARDIOVASC DIS, V58, P537, DOI 10.1016/j.pcad.2016.01.008
   Lavie CJ, 2016, PROG CARDIOVASC DIS, V58, P393, DOI 10.1016/j.pcad.2015.12.003
   Lavie CJ, 2015, HEART, V101, P1610, DOI 10.1136/heartjnl-2015-307966
   Lavie CJ, 2015, NAT REV ENDOCRINOL, V11, P55, DOI 10.1038/nrendo.2014.165
   Lavie CJ, 2014, J AM COLL CARDIOL, V63, P1345, DOI 10.1016/j.jacc.2014.01.022
   Lavie CJ, 2013, JACC-HEART FAIL, V1, P93, DOI 10.1016/j.jchf.2013.01.006
   Lavie CJ, 2009, J AM COLL CARDIOL, V53, P1925, DOI 10.1016/j.jacc.2008.12.068
   Lavie CJ, 2003, AM J CARDIOL, V91, P891, DOI 10.1016/S0002-9149(03)00031-6
   le Roux CW, 2017, LANCET, V389, P1399, DOI 10.1016/S0140-6736(17)30069-7
   Ledikwe JH, 2007, CONTEMP ENDOCRINOL S, P265, DOI 10.1007/978-1-59745-400-1_13
   Liu J, 2009, NAT MED, V15, P940, DOI 10.1038/nm.1994
   Logue J, 2010, BRIT MED J, V340, DOI 10.1136/bmj.c154
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Mahgerefteh Babak, 2013, Am Health Drug Benefits, V6, P423
   MESSERLI FH, 1983, ANN INTERN MED, V99, P757, DOI 10.7326/0003-4819-99-6-757
   MESSERLI FH, 1983, AM J MED, V74, P808, DOI 10.1016/0002-9343(83)91071-9
   Moholdt T, 2018, J AM COLL CARDIOL, V71, P1094, DOI 10.1016/j.jacc.2018.01.011
   Moholdt T, 2017, AM J MED, V130, P949, DOI 10.1016/j.amjmed.2017.01.043
   Moore LL, 2005, ARCH INTERN MED, V165, P1298, DOI 10.1001/archinte.165.11.1298
   Mraz M, 2014, J ENDOCRINOL, V222, pR113, DOI 10.1530/JOE-14-0283
   NAKAJIMA T, 1985, CIRCULATION, V71, P481, DOI 10.1161/01.CIR.71.3.481
   Nakamura K, 2014, J CARDIOL, V63, P250, DOI 10.1016/j.jjcc.2013.11.006
   Neeland IJ, 2013, CIRC-CARDIOVASC IMAG, V6, P800, DOI 10.1161/CIRCIMAGING.113.000532
   Ng M, 2014, LANCET, V384, P746
   O'Neil PM, 2018, LANCET, V392, P637, DOI 10.1016/S0140-6736(18)31773-2
   Odegaard JI, 2011, ANNU REV PATHOL-MECH, V6, P275, DOI 10.1146/annurev-pathol-011110-130138
   Ortega FB, 2016, CIRC RES, V118, P1752, DOI 10.1161/CIRCRESAHA.115.306883
   Ortega FB, 2015, PROG CARDIOVASC DIS, V58, P76, DOI 10.1016/j.pcad.2015.05.001
   Owen MK, 2014, ARTERIOSCL THROM VAS, V34, P1643, DOI 10.1161/ATVBAHA.114.303033
   Padwal RS, 2007, LANCET, V369, P71, DOI 10.1016/S0140-6736(07)60033-6
   Park YMM, 2015, J AM COLL CARDIOL, V65, P2091, DOI 10.1016/j.jacc.2015.03.517
   Parto P, 2015, EXPERT REV CARDIOVAS, V13, P1177, DOI 10.1586/14779072.2015.1092384
   Patel Dharmendrakumar A, 2012, Congest Heart Fail, V18, P4, DOI 10.1111/j.1751-7133.2011.00264.x
   Pi-Sunyer X, 2015, NEW ENGL J MED, V373, P11, DOI 10.1056/NEJMoa1411892
   Poirier P, 2006, CIRCULATION, V113, P898, DOI 10.1161/CIRCULATIONAHA.106.171016
   Rabah A, 2014, HEART FAIL REV, V19, P325, DOI 10.1007/s10741-013-9411-x
   Ridker PM, 2018, EUR HEART J, V39, P3499, DOI 10.1093/eurheartj/ehy310
   Secher A, 2014, J CLIN INVEST, V124, P4473, DOI 10.1172/JCI75276
   Sharma A, 2015, AM J CARDIOL, V115, P1428, DOI 10.1016/j.amjcard.2015.02.024
   Shaw K, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003817.pub3
   Shinbane JS, 1997, J AM COLL CARDIOL, V29, P709, DOI 10.1016/S0735-1097(96)00592-X
   Solinas G, 2017, MOL METAB, V6, DOI 10.1016/j.molmet.2016.12.001
   Strissel KJ, 2007, DIABETES, V56, P2910, DOI 10.2337/db07-0767
   Stunkard AJ, 2003, BIOL PSYCHIAT, V54, P330, DOI 10.1016/S0006-3223(03)00608-5
   Sun SY, 2012, ANNU REV NUTR, V32, P261, DOI 10.1146/annurev-nutr-071811-150623
   Talukdar S, 2012, NAT MED, V18, P1407, DOI 10.1038/nm.2885
   Tek C, 2016, PATIENT PREFER ADHER, V10, P751, DOI 10.2147/PPA.S84778
   Tseng CH, 2019, J FORMOS MED ASSOC, V118, pS3, DOI 10.1016/j.jfma.2018.07.009
   Unamuno X, 2018, EUR J CLIN INVEST, V48, DOI 10.1111/eci.12997
   Verpeut JL, 2014, EXPERT OPIN DRUG SAF, V13, P831, DOI 10.1517/14740338.2014.909405
   Wadden TA, 2013, INT J OBESITY, V37, P1443, DOI 10.1038/ijo.2013.120
   Wanahita N, 2008, AM HEART J, V155, P310, DOI 10.1016/j.ahj.2007.10.004
   Wang TJ, 2004, JAMA-J AM MED ASSOC, V292, P2471, DOI 10.1001/jama.292.20.2471
   Wang TJ, 2003, CIRCULATION, V107, P2920, DOI 10.1161/01.CIR.0000072767.89944.6E
   Wang ZJ, 2015, HEART, V101, P1631, DOI 10.1136/heartjnl-2014-307119
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Wessel TR, 2004, JAMA-J AM MED ASSOC, V292, P1179, DOI 10.1001/jama.292.10.1179
   Winer DA, 2011, NAT MED, V17, P610, DOI 10.1038/nm.2353
   Winer S, 2009, NAT MED, V15, P921, DOI 10.1038/nm.2001
   Wong CY, 2004, CIRCULATION, V110, P3081, DOI 10.1161/01.CIR.0000147184.13872.0F
   Wu D, 2011, SCIENCE, V332, P243, DOI 10.1126/science.1201475
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
   Zalesin KC, 2008, ENDOCRIN METAB CLIN, V37, P663, DOI 10.1016/j.ecl.2008.06.004
NR 141
TC 5
Z9 5
U1 2
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0342-5282
EI 1473-5660
J9 INT J REHABIL RES
JI Int. J. Rehabil. Res.
PD MAR
PY 2023
VL 46
IS 1
BP 14
EP 25
DI 10.1097/MRR.0000000000000565
PG 12
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Rehabilitation
GA 9J8TR
UT WOS:000940452700002
PM 36727942
DA 2025-06-11
ER

PT J
AU Bialkowska, A
   Górnicka, M
   Zielinska-Pukos, MA
   Hallmann, E
   Hamulka, J
AF Bialkowska, Agnieszka
   Gornicka, Magdalena
   Zielinska-Pukos, Monika A.
   Hallmann, Ewelina
   Hamulka, Jadwiga
TI Plasma Carotenoids and Polyphenols and Their Association with MetS: The
   Need for Nutritional Interventions
SO ANTIOXIDANTS
LA English
DT Article
DE metabolic disorders; MetS severity; carotenoids; polyphenols; lipids
   profile; glucose; inflammation; adults
ID METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   CHOLESTEROL; CONSUMPTION; FLAVONOIDS; MARKERS; OBESITY; FOODS; JUICE
AB Metabolic syndrome (MetS) is characterized by increased pro-oxidative stress and a chronic inflammation state and their consequent alterations. Several studies have highlighted the protective effect of carotenoids and polyphenols in MetS patients. This study aimed to evaluate the plasma level of selected carotenoids and polyphenols and to determine their relationship with MetS severity, MetS components, and inflammatory markers in Polish adults with metabolic disorders. It was designed as a cross-sectional study. The final study group comprised 275 adults, including 158 women and 117 men. Data were collected on the frequency of consumption of selected food groups. Anthropometric measurements and blood samples were taken to determine the concentration of carotenoids, polyphenols, and indicators (parameters) of metabolic disorders. Plasma concentrations of selected carotenoids and polyphenols were low in adults with MetS. The highest concentrations of carotenoids and polyphenols in the blood were observed for lutein and phenolic acids (including gallic and p-coumaric acids). Nevertheless, a correlation was found between the individual bioactive compounds and MetS components. In terms of the lipid profile, our study showed that the plasma of the selected carotenoids and polyphenols positively correlated with HDL cholesterol (zeaxanthin; total carotenoids), LDL cholesterol (chlorogenic acid), triglycerides (lycopene), and the total cholesterol (kaempferol). We found that the level of CRP as a marker of inflammation negatively correlated with the concentration of zeaxanthin. In our study group, no relationship was found between the dietary antioxidant intensity and the variables studied, which may be attributed to the low frequency of consumption of the sources of bioactive compounds, such as carotenoids and polyphenols, but also to the metabolic disorders. Further research is needed to determine whether these associations are causally related to the metabolic syndrome or are a result of the pathologies of the syndrome or improper diet with a low intake of vegetables and fruit.
C1 [Bialkowska, Agnieszka; Gornicka, Magdalena; Zielinska-Pukos, Monika A.; Hamulka, Jadwiga] Warsaw Univ Life Sci SGGW WULS, Inst Human Nutr Sci, Dept Human Nutr, PL-02787 Warsaw, Poland.
   [Hallmann, Ewelina] Warsaw Univ Life Sci SGGW WULS, Inst Human Nutr Sci, Dept Funct & Organ Food, PL-02787 Warsaw, Poland.
C3 Warsaw University of Life Sciences; Warsaw University of Life Sciences
RP Hamulka, J (corresponding author), Warsaw Univ Life Sci SGGW WULS, Inst Human Nutr Sci, Dept Human Nutr, PL-02787 Warsaw, Poland.
EM agnieszka_bialkowska@sggw.edu.pl; magdalena_gornicka@sggw.edu.pl;
   monika_zielinska_pukos@sggw.edu.pl; ewelina_hallmann@sggw.edu.pl;
   jadwiga_hamulka@sggw.edu.pl
RI Hamulka, Jadwiga/AAC-3436-2021; Górnicka, Magdalena/AAA-6820-2019;
   Hallmann, Ewelina/AAF-7809-2020; Hamulka, Jadwiga/B-1223-2018;
   Zielinska-Pukos, Monika/AAC-7113-2019
OI Magdalena, Gornicka/0000-0002-8805-186X; Hamulka,
   Jadwiga/0000-0003-4933-9016; Zielinska-Pukos,
   Monika/0000-0001-8894-6746; Hallmann, Ewelina/0000-0002-4855-7057
CR Abdel-Moneim A, 2022, ARCH PHYSIOL BIOCHEM, V128, P1188, DOI 10.1080/13813455.2020.1762659
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Aloo SO, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12020416
   Ambroselli D, 2023, NUTRIENTS, V15, DOI 10.3390/nu15030640
   [Anonymous], 2014, Dietary Habits and Nutrition Beliefs Questionnaire and the Manual for Developing of Nutritional Data KomPAN Kwestionariusz do Badania Pogladow i Zwyczajow Zywieniowych Oraz Procedura Opracowania Danych (KomPAN)
   Arfaoui L, 2021, MOLECULES, V26, DOI 10.3390/molecules26102959
   Beydoun MA, 2019, NUTR REV, V77, P32, DOI 10.1093/nutrit/nuy044
   Bialkowska A, 2023, NUTRIENTS, V15, DOI 10.3390/nu15102237
   Böhm V, 2021, NUTR REV, V79, P544, DOI 10.1093/nutrit/nuaa008
   Bohn T, 2021, NUTR RES REV, V34, P276, DOI 10.1017/S0954422421000147
   Bohn T, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8060179
   Chiva-Blanch G, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/5812401
   Cojocaru KA, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12030658
   Crowe-White K, 2017, CRIT REV FOOD SCI, V57, P152, DOI 10.1080/10408398.2015.1102861
   Dabeek WM, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102288
   Davis DW, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041120
   DeBoer MD, 2017, DIABET METAB SYND OB, V10, P65, DOI 10.2147/DMSO.S101624
   Di Lorenzo C, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010273
   Dinu M, 2018, EUR J CLIN NUTR, V72, P30, DOI 10.1038/ejcn.2017.58
   Eggersdorfer M, 2018, ARCH BIOCHEM BIOPHYS, V652, P18, DOI 10.1016/j.abb.2018.06.001
   Feldman F, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020672
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Gasmi A, 2022, MOLECULES, V27, DOI 10.3390/molecules27196280
   Grosso G, 2017, EUR J NUTR, V56, P1409, DOI 10.1007/s00394-016-1187-z
   Guo QP, 2020, SCI CHINA LIFE SCI, V63, P866, DOI 10.1007/s11427-019-9591-5
   Habanova M, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11112239
   Hamulka J, 2019, CLIN NUTR, V38, P1861, DOI 10.1016/j.clnu.2018.07.011
   Harari A, 2020, J NUTR, V150, P38, DOI 10.1093/jn/nxz184
   Harms LM, 2020, BRIT J NUTR, V123, P198, DOI 10.1017/S0007114519002538
   Huang K, 2015, J SCI FOOD AGR, V95, P1903, DOI 10.1002/jsfa.6896
   Javandoost A, 2017, ARYA ATHEROSCLER, V13, P245
   Jiang YW, 2021, ADV NUTR, V12, P1723, DOI 10.1093/advances/nmab048
   Koudoufio M, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9100982
   Kowalkowska J, 2018, NUTRIENTS, V10, DOI 10.3390/nu10121845
   Lee CY, 2023, J NUTR SCI, V12, DOI 10.1017/jns.2023.30
   Liu SM, 2021, AM J CLIN NUTR, V114, P9, DOI 10.1093/ajcn/nqab147
   Lu HJ, 2020, COMPR REV FOOD SCI F, V19, P3130, DOI 10.1111/1541-4337.12620
   Marhuenda-Muñoz M, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10030473
   Marseglia L, 2015, INT J MOL SCI, V16, P378, DOI 10.3390/ijms16010378
   Masenga SK, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24097898
   McKay GJ, 2021, EUR J NUTR, V60, P2631, DOI 10.1007/s00394-020-02455-2
   Millar CL, 2017, ADV NUTR, V8, P226, DOI 10.3945/an.116.014050
   Molteni C, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11101931
   Moran NE, 2018, ADV NUTR, V9, P465, DOI 10.1093/advances/nmy025
   Mubarak A, 2012, J AGR FOOD CHEM, V60, P9130, DOI 10.1021/jf303440j
   Myers GL, 2004, CIRCULATION, V110, pE545, DOI 10.1161/01.CIR.0000148980.87579.5E
   Nagao A, 2013, BIOSCI BIOTECH BIOCH, V77, P1055, DOI 10.1271/bbb.130025
   National Institute for Health and Excellence (NICE), NICE guideline NG136
   Neri-Numa IA, 2020, J FUNCT FOODS, V73, DOI 10.1016/j.jff.2020.104132
   Noce A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020630
   Pérez-Martínez P, 2017, NUTR REV, V75, P307, DOI 10.1093/nutrit/nux014
   Radtke J, 2002, EUR J NUTR, V41, P203, DOI 10.1007/s00394-002-0377-z
   Rana A, 2022, J FOOD BIOCHEM, V46, DOI 10.1111/jfbc.14264
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   Rao AV, 2007, PHARMACOL RES, V55, P207, DOI 10.1016/j.phrs.2007.01.012
   Rocha HR, 2023, NUTRIENTS, V15, DOI 10.3390/nu15102265
   Schoeneck M, 2021, NUTR METAB CARDIOVAS, V31, P1325, DOI 10.1016/j.numecd.2020.12.032
   Shen N, 2022, FOOD CHEM, V383, DOI 10.1016/j.foodchem.2022.132531
   Sholola MJ, 2022, METHOD ENZYMOL, V670, P423, DOI 10.1016/bs.mie.2022.03.021
   Sies H, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9090852
   Singh RB, 2022, NUTRIENTS, V14, DOI 10.3390/nu14040898
   Su Q, 2002, J CHROMATOGR B, V781, P393, DOI 10.1016/S1570-0232(02)00502-0
   Thomas MS, 2022, NUTRIENTS, V14, DOI 10.3390/nu14122548
   Toh DWK, 2021, BRIT J NUTR, V126, P1398, DOI 10.1017/S0007114521000143
   Tresserra-Rimbau A, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11020316
   Tsitsimpikou C, 2014, FOOD CHEM TOXICOL, V74, P9, DOI 10.1016/j.fct.2014.08.014
   Umbreen H., 2021, Carotenoids: Structure and Function in the Human Body eds, P421, DOI DOI 10.1007/978-3-030-46459-2_11
   Wang Y, 2014, J NUTR, V144, P1067, DOI 10.3945/jn.113.184317
   Willcox DC, 2014, MECH AGEING DEV, V136, P148, DOI 10.1016/j.mad.2014.01.002
   Wu K, 2003, J NUTR, V133, P1930, DOI 10.1093/jn/133.6.1930
   Xu H, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20010128
   Yu H, 2022, NUTRIENTS, V14, DOI 10.3390/nu14132566
   Zhou M, 2023, J ENZYM INHIB MED CH, V38, DOI 10.1080/14756366.2023.2199168
NR 73
TC 8
Z9 8
U1 2
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUL
PY 2023
VL 12
IS 7
AR 1336
DI 10.3390/antiox12071336
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA N1SO8
UT WOS:001034896300001
PM 37507876
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Singh, VP
   Aggarwal, R
   Singh, S
   Banik, A
   Ahmad, T
   Patnaik, BR
   Nappanveettil, G
   Singh, KP
   Aggarwal, ML
   Ghosh, B
   Agrawal, A
AF Singh, Vijay Pal
   Aggarwal, Rangoli
   Singh, Suchita
   Banik, Arpita
   Ahmad, Tanveer
   Patnaik, Bijay Ranjan
   Nappanveettil, Giridharan
   Singh, Kunal Pratap
   Aggarwal, Madan Lal
   Ghosh, Balaram
   Agrawal, Anurag
TI Metabolic Syndrome Is Associated with Increased Oxo-Nitrative Stress and
   Asthma-Like Changes in Lungs
SO PLOS ONE
LA English
DT Article
ID EXHALED NITRIC-OXIDE; BODY-MASS INDEX; AIRWAY INFLAMMATION;
   INSULIN-RESISTANCE; OBESE SUBJECTS; SYMPTOMS; DEFINITION; PREVALENCE;
   PREDICTOR; IMPACT
AB Epidemiological studies have shown an increased obesity-related risk of asthma. In support, obese mice develop airway hyperresponsiveness (AHR). However, it remains unclear whether the increased risk is a consequence of obesity, adipogenic diet, or the metabolic syndrome (MetS). Altered L-arginine and nitric oxide (NO) metabolism is a common feature between asthma and metabolic syndrome that appears independent of body mass. Increased asthma risk resulting from such metabolic changes would have important consequences in global health. Since high-sugar diets can induce MetS, without necessarily causing obesity, studies of their effect on arginine/NO metabolism and airway function could clarify this aspect. We investigated whether normal-weight mice with MetS, due to high-fructose diet, had dysfunctional arginine/NO metabolism and features of asthma. Mice were fed chow-diet, high-fat-diet, or high-fructose-diet for 18 weeks. Only the high-fat-diet group developed obesity or adiposity. Hyperinsulinemia, hyperglycaemia, and hyperlipidaemia were common to both high-fat-diet and high-fructose-diet groups and the high-fructose-diet group additionally developed hypertension. At 18 weeks, airway hyperresponsiveness (AHR) could be seen in obese high-fat-diet mice as well as non-obese high-fructose-diet mice, when compared to standard chow-diet mice. No inflammatory cell infiltrate or goblet cell metaplasia was seen in either high-fat-diet or high-fructose-diet mice. Exhaled NO was reduced in both these groups. This reduction in exhaled NO correlated with reduced arginine bioavailability in lungs. In summary, mice with normal weight but metabolic obesity show reduced arginine bioavailability, reduced NO production, and asthma-like features. Reduced NO related bronchodilation and increased oxo-nitrosative stress may contribute to the pathogenesis.
C1 [Singh, Vijay Pal; Aggarwal, Rangoli; Singh, Suchita; Banik, Arpita; Ahmad, Tanveer; Patnaik, Bijay Ranjan; Singh, Kunal Pratap; Ghosh, Balaram; Agrawal, Anurag] CSIR Inst Genom & Integrat Biol, Ctr Excellence Translat Res Asthma & Lung Dis, Delhi, India.
   [Nappanveettil, Giridharan] Natl Inst Nutr, Natl Ctr Lab Anim Sci, Hyderabad 500007, Andhra Pradesh, India.
   [Aggarwal, Madan Lal] Shriram Inst Ind Res, Delhi, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Institute of Genomics & Integrative Biology (IGIB); Indian Council of
   Medical Research (ICMR); ICMR - National Institute of Nutrition (NIN);
   ICMR - National Animal Resource Facility for Biomedical Research
   (NARFBR)
RP Singh, VP (corresponding author), CSIR Inst Genom & Integrat Biol, Ctr Excellence Translat Res Asthma & Lung Dis, Delhi, India.
EM vp.singh@igib.res.in
RI Singh, Prahat/HZH-4129-2023; Agrawal, Anurag/GZL-5821-2022; Pratap,
   Kunal/E-9042-2017
OI Ahmad, Tanveer/0000-0002-8384-5273; Singh, Vijay
   Pal/0000-0003-0547-3336; Pratap, Kunal/0000-0002-3888-2577; Agrawal,
   Anurag/0000-0002-0340-5252
FU Lady Tata Memorial Trust; CSIR (Council of Scientific and Industrial
   Research) MLP (Mega Laboratory Project) [5502]; CSIR (Council of
   Scientific and Industrial Research) BSC (Biological Science Cluster)
   project [0403]; DST (Department of Science and Technology); ICMR (Indian
   Council of Medical Research)
FX Funding was provided by the Lady Tata Memorial Trust, CSIR (Council of
   Scientific and Industrial Research) MLP (Mega Laboratory Project) 5502 &
   BSC (Biological Science Cluster) 0403 projects, the DST (Department of
   Science and Technology) Swarnjayanti awards for the financial support
   and ICMR (Indian Council of Medical Research) for scholarship of Suchita
   Singh. The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
CR Adeyeye Olufunke O, 2012, Int Arch Med, V5, P20, DOI 10.1186/1755-7682-5-20
   Agrawal A, 2011, AM J RESP CELL MOL, V44, P270, DOI 10.1165/rcmb.2010-0141TR
   Ahmad T, 2010, AM J RESP CELL MOL, V42, P3, DOI 10.1165/rcmb.2009-0137RC
   Ahmad T, 2009, J APPL PHYSIOL, V107, P295, DOI 10.1152/japplphysiol.00235.2009
   Akagiri S, 2008, J CLIN BIOCHEM NUTR, V42, P150, DOI 10.3164/jcbn.2008022
   ALVING K, 1993, EUR RESPIR J, V6, P1368
   [Anonymous], NATL HLTH STAT REPOR
   Assad N, 2013, AM J RESP CRIT CARE, V188, P319, DOI 10.1164/rccm.201303-0457OC
   Beigh SH, 2012, BIOINFORMATION, V8, P613, DOI 10.6026/97320630008613
   Berg CM, 2011, CHEST, V139, P1109, DOI 10.1378/chest.10-1299
   Beuther DA, 2009, CLIN CHEST MED, V30, P479, DOI 10.1016/j.ccm.2009.05.002
   Boulet LP, 2013, CLIN EXP ALLERGY, V43, P8, DOI 10.1111/j.1365-2222.2012.04040.x
   Brumpton BM, 2013, EUR RESPIR J, V42, P1495, DOI 10.1183/09031936.00046013
   Cottrell L, 2011, AM J RESP CRIT CARE, V183, P441, DOI 10.1164/rccm.201004-0603OC
   Eckel RH, 2010, LANCET, V375, P181, DOI 10.1016/S0140-6736(09)61794-3
   Farzan Sherry, 2013, J Allergy (Cairo), V2013, P602908, DOI 10.1155/2013/602908
   Fernando H, 2012, AM THOR SOC INT C AB, pA2197
   Galisteo M, 2008, J NUTR BIOCHEM, V19, P71, DOI 10.1016/j.jnutbio.2007.02.009
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Haldar P, 2008, AM J RESP CRIT CARE, V178, P218, DOI 10.1164/rccm.200711-1754OC
   Holguin Fernando, 2013, J Allergy (Cairo), V2013, P714595, DOI 10.1155/2013/714595
   Holguin F, 2013, AM J RESP CRIT CARE, V187, P153, DOI 10.1164/rccm.201207-1270OC
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Johnston RA, 2008, J APPL PHYSIOL, V104, P1727, DOI 10.1152/japplphysiol.00075.2008
   Komakula S, 2007, RESP RES, V8, DOI 10.1186/1465-9921-8-32
   Korhonen Riku, 2005, Current Drug Targets - Inflammation and Allergy, V4, P471, DOI 10.2174/1568010054526359
   Lee EJ, 2009, J ASTHMA, V46, P339, DOI 10.1080/02770900802660931
   Leishangthem G.D., 2010, MICROSCOPY SCI TECHN, V3, P347
   Leishangthem Geeta Devi, 2013, ISRN Allergy, V2013, P261297, DOI 10.1155/2013/261297
   Leone N, 2012, OBESITY, V20, P628, DOI 10.1038/oby.2011.308
   Lugogo NL, 2010, J APPL PHYSIOL, V108, P729, DOI 10.1152/japplphysiol.00845.2009
   Mabalirajan U, 2010, INT IMMUNOPHARMACOL, V10, P1514, DOI 10.1016/j.intimp.2010.08.025
   Mabalirajan U, 2010, J ALLERGY CLIN IMMUN, V125, P626, DOI 10.1016/j.jaci.2009.10.065
   Mosen DM, 2008, J ALLERGY CLIN IMMUN, V122, P507, DOI 10.1016/j.jaci.2008.06.024
   Novosad Shannon, 2013, J Allergy (Cairo), V2013, P538642, DOI 10.1155/2013/538642
   Sarkar S, 2006, INDIAN J MED RES, V123, P679
   Scott R, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-102
   Singh Suchita, 2013, J Allergy (Cairo), V2013, P627384, DOI 10.1155/2013/627384
   Stream AR, 2012, CURR OPIN ALLERGY CL, V12, P76, DOI 10.1097/ACI.0b013e32834eca41
   Sutherland TJT, 2008, AM J RESP CRIT CARE, V178, P469, DOI 10.1164/rccm.200802-301OC
   Thuesen BH, 2009, CLIN EXP ALLERGY, V39, P700, DOI 10.1111/j.1365-2222.2008.03197.x
   Todd DC, 2007, CLIN EXP ALLERGY, V37, P1049, DOI 10.1111/j.1365-2222.2007.02748.x
   van Huisstede A, 2013, J OBES, V2013, DOI 10.1155/2013/131349
   Varghese F, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0096801
   Wells SM, 2007, AM J RESP CELL MOL, V36, P520, DOI 10.1165/rcmb.2006-0302SM
   Wells SM, 2009, AM J RESP CELL MOL, V40, P179, DOI 10.1165/rcmb.2008-0148OC
NR 46
TC 56
Z9 60
U1 2
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 22
PY 2015
VL 10
IS 6
AR e0129850
DI 10.1371/journal.pone.0129850
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CL3FM
UT WOS:000356835800043
PM 26098111
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Boulos, M
   Mousa, RS
   Jeries, N
   Simaan, E
   Alam, K
   Bulus, B
   Assy, N
AF Boulos, Mariana
   Mousa, Rabia S.
   Jeries, Nizar
   Simaan, Elias
   Alam, Klode
   Bulus, Bulus
   Assy, Nimer
TI Hidden in the Fat: Unpacking the Metabolic Tango Between Metabolic
   Dysfunction-Associated Steatotic Liver Disease and Metabolic Syndrome
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE metabolic syndrome; MASLD mechanisms; future directions
ID COA CARBOXYLASE INHIBITION; FECAL MICROBIOTA TRANSPLANTATION; GAMMA
   AGONIST PIOGLITAZONE; ACTIVATED-RECEPTOR-GAMMA; PLACEBO-CONTROLLED
   TRIAL; IRRITABLE-BOWEL-SYNDROME; LIFE-STYLE MODIFICATION; NONALCOHOLIC
   STEATOHEPATITIS; INSULIN-RESISTANCE; OBETICHOLIC ACID
AB Metabolic syndrome (MetS) and metabolic dysfunction-associated steatotic liver disease (MASLD) are closely related, with rapidly increasing prevalence globally, driving significant public health concerns. Both conditions share common pathophysiological mechanisms such as insulin resistance (IR), adipose tissue dysfunction, oxidative stress, and gut microbiota dysbiosis, which contribute to their co-occurrence and progression. While the clinical implications of this overlap, including increased cardiovascular, renal, and hepatic risk, are well recognized, current diagnostic and therapeutic approaches remain insufficient due to the clinical and individuals' heterogeneity and complexity of these diseases. This review aims to provide an in-depth exploration of the molecular mechanisms linking MetS and MASLD, identify critical gaps in our understanding, and highlight existing challenges in early detection and treatment. Despite advancements in biomarkers and therapeutic interventions, the need for a comprehensive, integrated approach remains. The review also discusses emerging therapies targeting specific pathways, the potential of precision medicine, and the growing role of artificial intelligence in enhancing research and clinical management. Future research is urgently needed to combine multi-omics data, precision medicine, and novel biomarkers to better understand the complex interactions between MetS and MASLD. Collaborative, multidisciplinary efforts are essential to develop more effective diagnostic tools and therapies to address these diseases on a global scale.
C1 [Boulos, Mariana; Mousa, Rabia S.; Jeries, Nizar; Simaan, Elias; Alam, Klode; Bulus, Bulus; Assy, Nimer] Galilee Med Ctr, Internal Med Dept, IL-221001 Nahariyya, Israel.
   [Boulos, Mariana; Assy, Nimer] Bar Ilan Univ, Azrieli Fac Med, IL-1311502 Safed, Israel.
C3 Western Galilee Hospital; Bar Ilan University
RP Boulos, M (corresponding author), Galilee Med Ctr, Internal Med Dept, IL-221001 Nahariyya, Israel.; Boulos, M (corresponding author), Bar Ilan Univ, Azrieli Fac Med, IL-1311502 Safed, Israel.
EM marianab@gmc.gov.il; rabia.mousa@gmail.com; nizar_j_93@hotmail.com;
   eliasol937@gmail.com; klod_alam@hotmail.com; bulus.91@gmail.com;
   nimera@gmc.gov.il
CR Abdallah M, 2022, ANN HEPATOL, V27, DOI 10.1016/j.aohep.2022.100738
   Abdel-Razik A, 2018, EUR J GASTROEN HEPAT, V30, P1237, DOI 10.1097/MEG.0000000000001232
   Abenavoli L, 2018, PHARMACEUTICALS-BASE, V11, DOI 10.3390/ph11040104
   academic.oup, Molecular Actions of PPAR in Lipid Metabolism and Inflammation|Endocrine Reviews|Oxford Academic
   ADLER M, 1979, AM J MED, V67, P811, DOI 10.1016/0002-9343(79)90740-X
   Aggarwal Pankaj, 2021, Clin Liver Dis (Hoboken), V17, P392, DOI 10.1002/cld.1071
   Aguilar-Olivos NE, 2015, ANN HEPATOL, V14, P487, DOI 10.1016/S1665-2681(19)31170-6
   Aithal GP, 2008, GASTROENTEROLOGY, V135, P1176, DOI 10.1053/j.gastro.2008.06.047
   Akero Therapeutics' Phase 2b SYMMETRY Cohort D Study, Met Safety & Tolerability Endpoints and Showed Adding EFX to GLP-1 Therapy Significantly Improved Non-Invasive Markers of NASH-Related Disease
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Albillos A, 2020, J HEPATOL, V72, P558, DOI 10.1016/j.jhep.2019.10.003
   Ali AH, 2021, CURR MED CHEM, V28, P7427, DOI 10.2174/0929867328666210222092628
   Alkhouri N, 2020, EXPERT OPIN INV DRUG, V29, P135, DOI 10.1080/13543784.2020.1668374
   Allegretti JR, 2019, LANCET, V394, P420, DOI 10.1016/S0140-6736(19)31266-8
   Santos LAA, 2016, BIOMED RES INT, V2016, DOI 10.1155/2016/1423462
   [Anonymous], The Roles of Autophagy and Thyroid Hormone in the Pathogenesis and Treatment of NAFLD
   Anstee QM, 2020, J HEPATOL, V73, P505, DOI 10.1016/j.jhep.2020.04.003
   Anstee QM, 2018, NAT REV GASTRO HEPAT, V15, P425, DOI 10.1038/s41575-018-0010-0
   Anton SD, 2018, OBESITY, V26, P254, DOI 10.1002/oby.22065
   Arab JP, 2017, HEPATOLOGY, V65, P350, DOI 10.1002/hep.28709
   Arab JP, 2022, NAT REV GASTRO HEPAT, V19, P45, DOI 10.1038/s41575-021-00527-0
   Araki O, 2009, MOL ENDOCRINOL, V23, P308, DOI 10.1210/me.2008-0311
   Armstrong MJ, 2016, LANCET, V387, P679, DOI 10.1016/S0140-6736(15)00803-X
   Arnaud C, 2005, ARTERIOSCL THROM VAS, V25, P1231, DOI 10.1161/01.ATV.0000163840.63685.0c
   Aron-Wisnewsky J, 2012, J HEPATOL, V56, P225, DOI 10.1016/j.jhep.2011.04.022
   Aron-Wisnewsky J, 2016, METABOLISM, V65, P1124, DOI 10.1016/j.metabol.2016.05.004
   Aron-Wisnewsky J, 2015, THORAX, V70, P713, DOI 10.1136/thoraxjnl-2015-207212
   Athyros VG, 2018, CURR VASC PHARMACOL, V16, P246, DOI 10.2174/1570161115666170621082910
   Azad MA, 2018, BIOMED RES INT, V2018, DOI 10.1155/2018/9478630
   Azziz R, 2016, NAT REV DIS PRIMERS, V2, DOI 10.1038/nrdp.2016.57
   Bae JC, 2022, ENDOCRINOL METAB, V37, P858, DOI 10.3803/EnM.2022.605
   Ballestri S, 2014, WORLD J GASTROENTERO, V20, P1724, DOI 10.3748/wjg.v20.i7.1724
   Barchetta I, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113302
   Barchetta I, 2021, J ENDOCRINOL INVEST, V44, P979, DOI 10.1007/s40618-020-01392-5
   Baser O, 2024, J HEALTH ECON OUTCOM, V11, P86, DOI [10.36469/001c.123645, 10.36469/jheor.2024.XXXXXX]
   Basheer M, 2023, METABOLITES, V13, DOI 10.3390/metabo13080896
   Bednarz K, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23084334
   Behrouz V, 2020, J FOOD SCI, V85, P3611, DOI 10.1111/1750-3841.15367
   Belfort R, 2006, NEW ENGL J MED, V355, P2297, DOI 10.1056/NEJMoa060326
   Bergman A, 2020, CLIN PHARM DRUG DEV, V9, P514, DOI 10.1002/cpdd.782
   Bhat N, 2023, NUTRIENTS, V15, DOI 10.3390/nu15102323
   Bianco AC, 2006, J CLIN INVEST, V116, P2571, DOI 10.1172/JCI29812
   Blanco-Colio LM, 2003, KIDNEY INT, V63, P12, DOI 10.1046/j.1523-1755.2003.00744.x
   Blum A, 2009, ATHEROSCLEROSIS, V203, P325, DOI 10.1016/j.atherosclerosis.2008.08.022
   Briançon-Marjollet A, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/s13098-015-0018-3
   Brunner KT, 2020, LIVER INT, V40, P1339, DOI 10.1111/liv.14472
   Bugianesi E, 2005, HEPATOLOGY, V42, P987, DOI 10.1002/hep.20920
   Byrne CD, 2020, J HEPATOL, V72, P785, DOI 10.1016/j.jhep.2020.01.013
   Byrne CD, 2009, CLIN SCI, V116, P539, DOI 10.1042/CS20080253
   Calle RA, 2021, NAT MED, V27, P1836, DOI 10.1038/s41591-021-01489-1
   Cao W, 2020, J ULTRAS MED, V39, P51, DOI 10.1002/jum.15070
   Chen D, 2022, AGING-US, V14, P462, DOI 10.18632/aging.203824
   Chen S, 2023, HEPATOL INT, V17, P595, DOI 10.1007/s12072-023-10486-0
   Chen YH, 2023, NAT GENET, V55, P1640, DOI 10.1038/s41588-023-01497-6
   Cheng D, 2019, TRENDS FOOD SCI TECH, V91, P426, DOI 10.1016/j.tifs.2019.07.044
   Chu A, 2019, LAB CHIP, V19, P1808, DOI 10.1039/c8lc01394b
   Chung GE, 2012, J HEPATOL, V57, P150, DOI 10.1016/j.jhep.2012.02.027
   Clifford BL, 2021, CELL METAB, V33, P1671, DOI 10.1016/j.cmet.2021.06.012
   Commissioner O. of the FDA, Approves New Drug to Treat Travelers' Diarrhea
   Craven L, 2020, AM J GASTROENTEROL, V115, P1055, DOI 10.14309/ajg.0000000000000661
   Crossno JT, 2006, J CLIN INVEST, V116, P3220, DOI 10.1172/JCI28510
   Cui R, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/396545
   Cusi K, 2024, NEW ENGL J MED, V390, P559, DOI 10.1056/NEJMe2314365
   Czech MP, 2020, MOL METAB, V34, P27, DOI 10.1016/j.molmet.2019.12.014
   da Silva Pereira Evelyn Nunes Goulart, 2025, Biomed Pharmacother, V183, P117805, DOI 10.1016/j.biopha.2024.117805
   De Chiara F, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9030248
   Deacon CF, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00080
   Decharatanachart P, 2021, THER ADV GASTROENTER, V14, DOI 10.1177/17562848211062807
   DeFronzo RA, 2012, DIABETES OBES METAB, V14, P5, DOI 10.1111/j.1463-1326.2011.01511.x
   Del Barrio M, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24076123
   Diab R, 2024, CELL BIOCHEM BIOPHYS, V82, P1583, DOI 10.1007/s12013-024-01314-9
   Ding C, 2022, ACTA DIABETOL, V59, P519, DOI 10.1007/s00592-021-01830-7
   DiNicolantonio JJ, 2017, OPEN HEART, V4, DOI 10.1136/openhrt-2017-000631
   Doumas M, 2018, CURR PHARM DESIGN, V24, P4587, DOI 10.2174/1381612825666190117114305
   Drapkina OM, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24098445
   DuPont HL, 2007, CLIN GASTROENTEROL H, V5, P451, DOI 10.1016/j.cgh.2007.02.004
   EASL, 2016, OBESITY FACTS, V9, P65, DOI [10.1159/000443344, 10.1007/s00125-016-3902-y, 10.1016/j.jhep.2015.11.004]
   Eckard C, 2013, THER ADV GASTROENTER, V6, P249, DOI 10.1177/1756283X13484078
   Ekstedt M, 2015, HEPATOLOGY, V61, P1547, DOI 10.1002/hep.27368
   Eslam M, 2020, J HEPATOL, V73, P202, DOI 10.1016/j.jhep.2020.03.039
   Eslam M, 2020, GASTROENTEROLOGY, V158, P1999, DOI 10.1053/j.gastro.2019.11.312
   Eslam M, 2019, HEPATOL INT, V13, P662, DOI 10.1007/s12072-019-09990-z
   Estes C, 2018, J HEPATOL, V69, P896, DOI 10.1016/j.jhep.2018.05.036
   Farnesoid X, Receptor Activation by Bile Acids Suppresses Lipid Peroxidation and Ferroptosis|Nature Communications
   FDA, Grants Tentative Approval to Generic Version of Rifaximin for IBS-D
   FDA FDA, 2024, Approves First Treatment for Patients with Liver Scarring Due to Fatty Liver Disease
   Feng WH, 2017, J DIABETES, V9, P800, DOI 10.1111/1753-0407.12555
   Ferdous SE, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25168731
   Filip R, 2018, CLIN INTERV AGING, V13, P1879, DOI 10.2147/CIA.S170533
   Fleishman JS, 2024, SIGNAL TRANSDUCT TAR, V9, DOI 10.1038/s41392-024-01811-6
   Friedman SL, 2018, NAT MED, V24, P908, DOI 10.1038/s41591-018-0104-9
   Fujita T, 2016, INFLAMM REGEN, V36, DOI 10.1186/s41232-016-0005-6
   Gaggini M, 2013, NUTRIENTS, V5, P1544, DOI 10.3390/nu5051544
   Garvey WT, 2018, METABOLISM, V85, P32, DOI 10.1016/j.metabol.2018.02.002
   Gastaldelli A, 2019, JHEP REP, V1, P312, DOI 10.1016/j.jhepr.2019.07.002
   Gastrointestinal Drugs Advisory Committee, NOT M
   Ghezzi C, 2018, DIABETOLOGIA, V61, P2087, DOI 10.1007/s00125-018-4656-5
   Gleeson M, 2011, NAT REV IMMUNOL, V11, P607, DOI 10.1038/nri3041
   Goedeke L, 2018, HEPATOLOGY, V68, P2197, DOI 10.1002/hep.30097
   Golomb BA, 2008, AM J CARDIOVASC DRUG, V8, P373, DOI 10.2165/0129784-200808060-00004
   Goodwin B, 2000, MOL CELL, V6, P517, DOI 10.1016/S1097-2765(00)00051-4
   Grattagliano I, 2012, CLIN BIOCHEM, V45, P610, DOI 10.1016/j.clinbiochem.2012.03.024
   Guo Q, 2023, NUTRIENTS, V15, DOI 10.3390/nu15173722
   Gutiérrez-Cuevas J, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222111629
   Haas JT, 2016, ANNU REV PHYSIOL, V78, P181, DOI 10.1146/annurev-physiol-021115-105331
   Hadi A, 2019, CRIT REV FOOD SCI, V59, P2494, DOI 10.1080/10408398.2018.1458021
   Hagstroem H, 2024, BIOCATAL AGR BIOTECH, V56, pE76, DOI 10.1016/j.jhep.2023.08.026
   Hamaguchi E, 2010, DIABETES CARE, V33, P284, DOI 10.2337/dc09-0148
   Han SY, 2021, ACTA DIABETOL, V58, P495, DOI 10.1007/s00592-020-01652-z
   Harrison SA, 2024, NEW ENGL J MED, V390, P497, DOI 10.1056/NEJMoa2309000
   Harrison SA, 2023, LANCET GASTROENTEROL, V8, P1080, DOI 10.1016/S2468-1253(23)00272-8
   Harrison SA, 2023, JHEP REP, V5, DOI 10.1016/j.jhepr.2022.100563
   Hartman ML, 2020, DIABETES CARE, V43, P1352, DOI 10.2337/dc19-1892
   Haukeland JW, 2009, SCAND J GASTROENTERO, V44, P853, DOI 10.1080/00365520902845268
   Heindel JJ, 2017, REPROD TOXICOL, V68, P3, DOI 10.1016/j.reprotox.2016.10.001
   Hickman IJ, 2004, GUT, V53, P413, DOI 10.1136/gut.2003.027581
   Hönes GS, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms232213714
   Holscher HD, 2017, GUT MICROBES, V8, P172, DOI 10.1080/19490976.2017.1290756
   Horn CL, 2022, HEPATOL COMMUN, V6, P12, DOI 10.1002/hep4.1801
   Horwich TB, 2004, J AM COLL CARDIOL, V43, P642, DOI 10.1016/j.jacc.2003.07.049
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Hu YM, 2012, J TRAVEL MED, V19, P352, DOI 10.1111/j.1708-8305.2012.00650.x
   Huang DIQ, 2021, NAT REV GASTRO HEPAT, V18, P223, DOI 10.1038/s41575-020-00381-6
   Huang Q, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.693507
   Huang YS, 2022, MEDICINE, V101, DOI 10.1097/MD.0000000000031437
   Hudish LI, 2019, J CLIN INVEST, V129, P4001, DOI 10.1172/JCI129188
   Hutchison AL, 2023, J HEPATOL, V79, P1524, DOI 10.1016/j.jhep.2023.08.030
   Iacono A, 2011, J NUTR BIOCHEM, V22, P699, DOI 10.1016/j.jnutbio.2010.10.002
   Iorio N, 2015, CLIN EXP GASTROENTER, V8, P159, DOI 10.2147/CEG.S67231
   Islam MM, 2020, CANCERS, V12, DOI 10.3390/cancers12030671
   Ito D, 2017, DIABETES CARE, V40, P1364, DOI 10.2337/dc17-0518
   Ji Y, 2022, SLEEP MED, V95, P16, DOI 10.1016/j.sleep.2022.04.006
   Jiang J, 2022, HEPATOL COMMUN, V6, P3363, DOI 10.1002/hep4.2099
   Jornayvaz FR, 2012, ENDOCRINOLOGY, V153, P583, DOI 10.1210/en.2011-1793
   Josloff K, 2022, J CARDIOVASC DEV DIS, V9, DOI 10.3390/jcdd9120419
   Kahl S, 2020, DIABETES CARE, V43, P298, DOI 10.2337/dc19-0641
   Kalapala R, 2023, J CLIN EXP HEPATOL, V13, P149, DOI 10.1016/j.jceh.2022.06.009
   Kaplan DE, 2019, GASTROENTEROLOGY, V156, P1693, DOI 10.1053/j.gastro.2019.01.026
   Karim Gres, 2023, touchREV Endocrinol, V19, P60, DOI 10.17925/EE.2023.19.1.60
   Karlson BW, 2016, AM J CARDIOL, V117, P1444, DOI 10.1016/j.amjcard.2016.02.011
   Kelly KL, 2020, NAT METAB, V2, P1163, DOI 10.1038/s42255-020-00272-9
   Kersten S, 2014, MOL METAB, V3, P354, DOI 10.1016/j.molmet.2014.02.002
   Khan MY, 2019, EUR J GASTROEN HEPAT, V31, P703, DOI 10.1097/MEG.0000000000001371
   Kim CW, 2017, CELL METAB, V26, P394, DOI 10.1016/j.cmet.2017.07.009
   Kim G, 2018, J HEPATOL, V68, P476, DOI 10.1016/j.jhep.2017.10.018
   Kim H, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22094495
   Kimer N, 2014, ALIMENT PHARM THER, V40, P123, DOI 10.1111/apt.12803
   Kirwan JP, 2017, CLEV CLIN J MED, V84, pS15, DOI 10.3949/ccjm.84.s1.03
   Kleiner DE, 2019, JAMA NETW OPEN, V2, DOI 10.1001/jamanetworkopen.2019.12565
   Kliewer SA, 2015, DIGEST DIS, V33, P327, DOI 10.1159/000371670
   Kobyliak N, 2018, J GASTROINTEST LIVER, V27, P41, DOI 10.15403/jgld.2014.1121.271.kby
   Koh A, 2018, CELL, V175, P947, DOI 10.1016/j.cell.2018.09.055
   Koo HL, 2010, CURR OPIN GASTROEN, V26, P17, DOI 10.1097/MOG.0b013e328333dc8d
   Koureta E, 2023, ANN GASTROENTEROL, V36, P378, DOI 10.20524/aog.2023.0806
   Kuchay MS, 2018, DIABETES CARE, V41, P1801, DOI 10.2337/dc18-0165
   Kwok RM, 2013, HEPATOLOGY, V58, P1166, DOI 10.1002/hep.26390
   Lacy BE, 2023, CLIN THER, V45, P198, DOI 10.1016/j.clinthera.2023.01.010
   Lambrecht J, 2020, CELL MOL GASTROENTER, V10, P859, DOI 10.1016/j.jcmgh.2020.07.002
   Lazo M, 2013, AM J EPIDEMIOL, V178, P38, DOI 10.1093/aje/kws448
   Lee JI, 2021, AM J GASTROENTEROL, V116, P116, DOI 10.14309/ajg.0000000000000845
   Lefer AM, 2001, CARDIOVASC RES, V49, P281, DOI 10.1016/S0008-6363(00)00247-9
   Lei YN, 2022, NAT COMMUN, V13, DOI 10.1038/s41467-022-34671-1
   Leiter LA, 2016, DIABETES METAB, V42, P25, DOI 10.1016/j.diabet.2015.10.003
   Lembo A, 2016, GASTROENTEROLOGY, V151, P1113, DOI 10.1053/j.gastro.2016.08.003
   Leung C, 2016, NAT REV GASTRO HEPAT, V13, P412, DOI 10.1038/nrgastro.2016.85
   Li JG, 2005, J APPL PHYSIOL, V99, P1643, DOI 10.1152/japplphysiol.00522.2005
   Li J, 2019, LANCET GASTROENTEROL, V4, P389, DOI 10.1016/S2468-1253(19)30039-1
   Li MW, 2022, SIGNAL TRANSDUCT TAR, V7, DOI 10.1038/s41392-022-01073-0
   Li YF, 2022, REV ENDOCR METAB DIS, V23, P387, DOI 10.1007/s11154-021-09681-x
   Lim S, 2021, TRENDS ENDOCRIN MET, V32, P500, DOI 10.1016/j.tem.2021.04.008
   Lin J, 2024, FRONT MICROBIOL, V15, DOI 10.3389/fmicb.2024.1379064
   Liu D, 2023, BMC MED, V21, DOI 10.1186/s12916-023-02775-0
   Liu JN, 2010, CHINESE MED J-PEKING, V123, P74, DOI 10.3760/cma.j.issn.0366-6999.2010.01.013
   Liu J, 2018, ACTA BIOCH BIOPH SIN, V50, P1200, DOI 10.1093/abbs/gmy131
   Lonardo A, 2021, ADV THER, V38, P2130, DOI 10.1007/s12325-021-01690-1
   Lonardo A, 2018, J HEPATOL, V68, P335, DOI 10.1016/j.jhep.2017.09.021
   Longo M, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20092358
   Loomba R, 2024, NEW ENGL J MED, V391, P299, DOI 10.1056/NEJMoa2401943
   Lu YX, 2023, MEDICINE, V102, DOI 10.1097/MD.0000000000035285
   LUDWIG J, 1980, MAYO CLIN PROC, V55, P434
   Luong XG, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0240338
   Ma XF, 2021, AM J TRANSL RES, V13, P12704
   Makri E, 2016, WORLD J GASTROENTERO, V22, P9039, DOI 10.3748/wjg.v22.i41.9039
   Malagnino V, 2019, AM J PHYSIOL-GASTR L, V317, pG751, DOI 10.1152/ajpgi.00330.2018
   Mancini GBJ, 2016, CAN J CARDIOL, V32, pS35, DOI 10.1016/j.cjca.2016.01.003
   Mantovani A, 2022, GUT, V71, P778, DOI 10.1136/gutjnl-2021-324191
   Mantovani A, 2018, DIABETES CARE, V41, P372, DOI 10.2337/dc17-1902
   Marra F, 2018, J HEPATOL, V68, P280, DOI 10.1016/j.jhep.2017.11.014
   Mateo-Marín MA, 2024, J LIPID RES, V65, DOI 10.1016/j.jlr.2024.100676
   Matsumoto M, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0228212
   Mazza A, 2012, EXP DIABETES RES, DOI 10.1155/2012/716404
   McConnell MJ, 2023, HEPATOLOGY, V78, P649, DOI 10.1097/HEP.0000000000000207
   mdpi, Combined Therapy with a CCR2/CCR5 Antagonist and FGF21 Analogue Synergizes in Ameliorating Steatohepatitis and Fibrosis
   Meex RCR, 2017, NAT REV ENDOCRINOL, V13, P508, DOI 10.1038/nrendo.2017.56
   Meng DC, 2023, DIABET METAB SYND OB, V16, P4043, DOI 10.2147/DMSO.S437865
   Mennigen R, 2009, ANN NY ACAD SCI, V1165, P183, DOI 10.1111/j.1749-6632.2009.04059.x
   Mesarwi OA, 2015, SLEEP, V38, P1583, DOI 10.5665/sleep.5052
   Mika A, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00026
   Mohanty P, 2004, J CLIN ENDOCR METAB, V89, P2728, DOI 10.1210/jc.2003-032103
   Montemayor S, 2022, NUTRIENTS, V14, DOI 10.3390/nu14153186
   Moon SS, 2012, ENDOCRINE, V42, P423, DOI 10.1007/s12020-012-9639-6
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Mridha AR, 2017, J HEPATOL, V66, P1037, DOI 10.1016/j.jhep.2017.01.022
   Müller TD, 2019, MOL METAB, V30, P72, DOI 10.1016/j.molmet.2019.09.010
   Mullur R, 2014, PHYSIOL REV, V94, P355, DOI 10.1152/physrev.00030.2013
   Musso G, 2014, PLOS MED, V11, DOI 10.1371/journal.pmed.1001680
   Nagashima K, 2005, J CLIN INVEST, V115, P1323, DOI 10.1172/JCI200523219
   Nakagawa Y, 2016, SCI REP-UK, V6, DOI 10.1038/srep39182
   Nakchbandi IA, 2014, WORLD J GASTROENTERO, V20, P9427, DOI 10.3748/wjg.v20.i28.9427
   Nam D, 2022, JHEP REP, V4, DOI 10.1016/j.jhepr.2022.100443
   Nathani Rohit R, 2023, Gastroenterol Hepatol (N Y), V19, P371
   ndltd.org, Global ETD Search
   Nesto RW, 2003, CIRCULATION, V108, P2941, DOI 10.1161/01.CIR.0000103683.99399.7E
   Neuschwander-Tetri BA, 2015, LANCET, V385, P956, DOI 10.1016/S0140-6736(14)61933-4
   Bezerra RMN, 2012, METABOLISM, V61, P1606, DOI 10.1016/j.metabol.2012.04.006
   Nian FL, 2023, J CLIN TRANSL HEPATO, V11, P763, DOI 10.14218/JCTH.2022.00415
   nih, Renal Sodium-Glucose Cotransporter Inhibition in the Management of Type 2 Diabetes Mellitus
   nih, Influence of Obstructive Sleep Apnea on Fatty Liver Disease: Role of Chronic Intermittent Hypoxia-PubMed
   nih, NASH in Lean Individuals-PubMed
   Non-Alcoholic Fatty Liver Disease and Gut, Microbial Dysbiosis-Underlying Mechanisms and Gut Microbiota
   Orasanu G, 2008, J AM COLL CARDIOL, V52, P869, DOI 10.1016/j.jacc.2008.04.055
   Paglialunga S, 2016, LIPIDS HEALTH DIS, V15, DOI 10.1186/s12944-016-0321-5
   Pardee PE, 2012, ALIMENT PHARM THER, V35, P248, DOI 10.1111/j.1365-2036.2011.04924.x
   Parnell JA, 2012, LIVER INT, V32, P701, DOI 10.1111/j.1478-3231.2011.02730.x
   Pastori D, 2015, DIGEST LIVER DIS, V47, P4, DOI 10.1016/j.dld.2014.07.170
   Patidar KR, 2013, METAB BRAIN DIS, V28, P307, DOI 10.1007/s11011-013-9383-5
   Pelton PD, 2005, CURR TOP MED CHEM, V5, P265, DOI 10.2174/1568026053544588
   Pimentel M, 2011, NEW ENGL J MED, V364, P22, DOI 10.1056/NEJMoa1004409
   Pirola CJ, 2022, CLIN MOL HEPATOL, V28, P935, DOI 10.3350/cmh.2022.0175
   Polyzos SA, 2016, METABOLISM, V65, P1062, DOI 10.1016/j.metabol.2015.11.006
   Popa SL, 2021, DIAGNOSTICS, V11, DOI 10.3390/diagnostics11061078
   Pradhan R, 2022, DIABETES CARE, V45, P819, DOI 10.2337/dc21-1953
   Pugliese N, 2025, CANCERS, V17, DOI 10.3390/cancers17050722
   Ratziu V, 2008, GASTROENTEROLOGY, V135, P100, DOI 10.1053/j.gastro.2008.03.078
   Ratziu V, 2023, J HEPATOL, V78, P479, DOI 10.1016/j.jhep.2022.10.023
   Ratziu V, 2010, HEPATOLOGY, V51, P445, DOI 10.1002/hep.23270
   Reinis J, 2023, J HEPATOL, V78, DOI 10.1016/j.jhep.2022.09.012
   Ren TQ, 2021, CLIN RES HEPATOL GAS, V45, DOI 10.1016/j.clinre.2021.101641
   Renga B, 2009, WORLD J GASTROENTERO, V15, P2097, DOI 10.3748/wjg.15.2097
   Rich NE, 2018, CLIN GASTROENTEROL H, V16, P198, DOI 10.1016/j.cgh.2017.09.041
   Rinella ME, 2024, HEPATOLOGY, V79, P674, DOI 10.1097/HEP.0000000000000607
   Ritter MJ, 2020, HEPATOLOGY, V72, P742, DOI 10.1002/hep.31296
   Rosato V, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16183415
   Ross TT, 2020, CELL MOL GASTROENTER, V10, P829, DOI 10.1016/j.jcmgh.2020.06.001
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sakurai Y, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22084156
   Saltiel AR, 2017, J CLIN INVEST, V127, P1, DOI [10.1172/JCI92035, 10.1172/jci92035]
   Santos RD, 2019, ATHEROSCLEROSIS, V282, P110, DOI 10.1016/j.atherosclerosis.2019.01.029
   Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929
   Schramm C, 2022, JHEP REP, V4, DOI 10.1016/j.jhepr.2022.100544
   Schwabe RF, 2020, GASTROENTEROLOGY, V158, P1913, DOI 10.1053/j.gastro.2019.11.311
   Scott LJ, 2014, DRUGS, V74, P2153, DOI 10.1007/s40265-014-0300-y
   Sebastiani G, 2021, CAN LIVER J, DOI 10.3138/canlivj-2021-0030
   Seghieri M, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00649
   Sghaireen MG, 2022, DIAGNOSTICS, V12, DOI 10.3390/diagnostics12123117
   Shen CP, 2021, J ETHNOPHARMACOL, V279, DOI 10.1016/j.jep.2021.114340
   Shimizu M, 2019, DIABETES OBES METAB, V21, P285, DOI 10.1111/dom.13520
   Shulman GI, 2000, J CLIN INVEST, V106, P171, DOI 10.1172/JCI10583
   Simoes ICM, 2018, INT J BIOCHEM CELL B, V95, P93, DOI 10.1016/j.biocel.2017.12.019
   Simon TG, 2016, HEPATOLOGY, V64, P47, DOI 10.1002/hep.28506
   Sinha RA, 2018, NAT REV ENDOCRINOL, V14, P259, DOI 10.1038/nrendo.2018.10
   Slavin J, 2013, NUTRIENTS, V5, P1417, DOI 10.3390/nu5041417
   Song LT, 2025, CELL METAB, V37, P104, DOI 10.1016/j.cmet.2024.09.008
   Song LT, 2022, HEPATOLOGY, V76, P1105, DOI 10.1002/hep.32404
   Sookoian S, 2013, OBES SURG, V23, P1815, DOI 10.1007/s11695-013-0981-4
   Spahis S, 2017, ANTIOXID REDOX SIGN, V26, P519, DOI 10.1089/ars.2016.6776
   Statin Therapy and Myocardial No-Reflow-Calvert, 2006, British JOURNAL of Pharmacology-Wiley Online Library, DOI [10.1038/sj.bjp.0706863, DOI 10.1038/SJ.BJP.0706863]
   Stefan N, 2019, LANCET DIABETES ENDO, V7, P313, DOI 10.1016/S2213-8587(18)30154-2
   Stefan N, 2013, NAT REV ENDOCRINOL, V9, P144, DOI 10.1038/nrendo.2012.258
   Stein EA, 1998, AM J CARDIOL, V81, p66B, DOI 10.1016/S0002-9149(98)00041-1
   Stiede K, 2017, HEPATOLOGY, V66, P324, DOI 10.1002/hep.29246
   Struben VMD, 2000, AM J MED, V108, P9, DOI 10.1016/S0002-9343(99)00315-0
   Sveinbjornsson G, 2022, NAT GENET, V54, P1652, DOI 10.1038/s41588-022-01199-5
   Tahrani AA, 2013, LANCET DIABETES ENDO, V1, P140, DOI 10.1016/S2213-8587(13)70050-0
   Tang HY, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1254459
   Tang J, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.800490
   Tang YH, 2024, BIOMED PHARMACOTHER, V175, DOI 10.1016/j.biopha.2024.116658
   Targher G, 2020, GUT, V69, P1691, DOI 10.1136/gutjnl-2020-320622
   Targher G, 2016, J HEPATOL, V65, P589, DOI 10.1016/j.jhep.2016.05.013
   Taylor RS, 2020, GASTROENTEROLOGY, V158, P1611, DOI 10.1053/j.gastro.2020.01.043
   Tian LY, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24032652
   Torres MCP, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122971
   Torres-Pena JD, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.777131
   van den Berg EH, 2019, LIVER INT, V39, P1343, DOI 10.1111/liv.14116
   Van Der Heijden GJ, 2010, MED SCI SPORT EXER, V42, P1973, DOI 10.1249/MSS.0b013e3181df16d9
   Vargas Jose Ignacio, 2017, Curr Gastroenterol Rep, V19, P43, DOI 10.1007/s11894-017-0584-7
   Velliou RI, 2024, CELLS-BASEL, V13, DOI 10.3390/cells13221827
   Vieira-Silva S, 2020, NATURE, V581, P310, DOI 10.1038/s41586-020-2269-x
   Vilar-Gomez E, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-023597
   Vilar-Gomez E, 2016, HEPATOLOGY, V63, P1875, DOI 10.1002/hep.28484
   Vilar-Gomez E, 2015, GASTROENTEROLOGY, V149, P367, DOI 10.1053/j.gastro.2015.04.005
   Vilas-Boas EA, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10123328
   von Loeffelholz C, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9121853
   Vyas U, 2012, GASTROENT RES PRACT, V2012, DOI 10.1155/2012/872716
   Wang D, 2022, FRONT PHYSIOL, V13, DOI 10.3389/fphys.2022.941706
   Wang SN, 2021, FOOD FUNCT, V12, P8760, DOI [10.1039/D1FO01050F, 10.1039/d1fo01050f]
   Wang Yanyan, 2024, Med Rev (2021), V4, P262, DOI 10.1515/mr-2024-0020
   Wang YH, 2015, NAT REV MOL CELL BIO, V16, P678, DOI 10.1038/nrm4074
   Wei M, 2023, WORLD J GASTROENTERO, V29, P3280, DOI 10.3748/wjg.v29.i21.3280
   Willner IR, 2001, AM J GASTROENTEROL, V96, P2957
   Wong VWS, 2021, CLIN GASTROENTEROL H, V19, P2161, DOI 10.1016/j.cgh.2020.10.046
   Wong VWS, 2018, NAT REV GASTRO HEPAT, V15, P461, DOI 10.1038/s41575-018-0014-9
   Xia J, 2020, J CHEM INF MODEL, V60, P1202, DOI 10.1021/acs.jcim.9b01030
   Xiang D, 2023, BIOMED PHARMACOTHER, V168, DOI 10.1016/j.biopha.2023.115606
   Xu J, 2023, HEPATOLOGY, V77, P20, DOI 10.1002/hep.32599
   Xue L, 2017, SCI REP-UK, V7, DOI 10.1038/srep45176
   Yamashita S, 2010, J ATHEROSCLER THROMB, V17, P436, DOI 10.5551/jat.5405
   Yan JH, 2019, HEPATOLOGY, V69, P2414, DOI 10.1002/hep.30320
   Yan YR, 2021, FREE RADICAL BIO MED, V165, P401, DOI 10.1016/j.freeradbiomed.2021.01.053
   Yang B, 2024, FRONT ENDOCRINOL, V15, DOI 10.3389/fendo.2024.1450317
   Yano M, 2007, CIRC RES, V100, P1442, DOI 10.1161/01.RES.0000268411.49545.9c
   Ye JP, 2013, FRONT MED-PRC, V7, P14, DOI 10.1007/s11684-013-0262-6
   Younossi ZM, 2023, HEPATOLOGY, V77, P1335, DOI 10.1097/HEP.0000000000000004
   Younossi ZM, 2021, HEPATOLOGY, V73, P1194, DOI 10.1002/hep.31420
   Younossi ZM, 2019, LANCET, V394, P2184, DOI 10.1016/S0140-6736(19)33041-7
   Yousefi B, 2019, J CELL PHYSIOL, V234, P8008, DOI 10.1002/jcp.27559
   Zelber-Sagi S, 2017, LIVER INT, V37, P936, DOI 10.1111/liv.13435
   Zeng J, 2020, WORLD J GASTROENTERO, V26, P1792, DOI 10.3748/wjg.v26.i15.1792
   Zhang C, 2024, J NUTR BIOCHEM, V125, DOI 10.1016/j.jnutbio.2023.109546
   Zhang HJ, 2021, CHINESE MED J-PEKING, V134, P1593, DOI 10.1097/CM9.0000000000001513
   Zhang JZ, 2019, GENE EXPRESSION, V19, P187, DOI 10.3727/105221619X15553433838609
   Zhang L, 2013, ANTIMICROB AGENTS CH, V57, P3659, DOI 10.1128/AAC.00670-13
   Zhang SQ, 2024, MOLECULES, V29, DOI 10.3390/molecules29081859
   Zhao S, 2020, NATURE, V579, P586, DOI 10.1038/s41586-020-2101-7
   Zhao Y, 2023, MEDICINE, V102, DOI 10.1097/MD.0000000000033110
   Zhou XD, 2022, CARDIOVASC DIABETOL, V21, DOI 10.1186/s12933-022-01697-0
   Zhou Z, 2020, CARDIOVASC DIABETOL, V19, DOI 10.1186/s12933-020-01085-6
   Zou B, 2020, J INTERN MED, V288, P139, DOI 10.1111/joim.13069
   Zou BY, 2023, CLIN GASTROENTEROL H, V21, P435, DOI 10.1016/j.cgh.2022.01.057
NR 329
TC 1
Z9 1
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR 7
PY 2025
VL 26
IS 7
AR 3448
DI 10.3390/ijms26073448
PG 44
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 1FR1Q
UT WOS:001463911000001
PM 40244398
DA 2025-06-11
ER

PT J
AU Reddy, P
   Lent-Schochet, D
   Ramakrishnan, N
   McLaughlin, M
   Jialal, I
AF Reddy, Priya
   Lent-Schochet, Daniella
   Ramakrishnan, Neeraj
   McLaughlin, Matthew
   Jialal, Ishwarlal
TI Metabolic syndrome is an inflammatory disorder: A conspiracy between
   adipose tissue and phagocytes
SO CLINICA CHIMICA ACTA
LA English
DT Review
DE Inflammation; Adipokines; Metabolic syndrome; C-reactive protein;
   Fibrinogen; Macrophages; Chemokines; Metabolomics
ID C-REACTIVE PROTEIN; NEUTROPHIL-LYMPHOCYTE RATIO;
   LIPOPOLYSACCHARIDE-BINDING PROTEIN; TUMOR-NECROSIS-FACTOR;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; ENDOTHELIAL-CELLS;
   PLASMA-FIBRINOGEN; OBESITY; RISK
AB Metabolic syndrome (MetS) describes a cluster of cardio-metabolic factors that predispose to type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular disease (ASCVD). While 35% of Americans suffer from this disorder, the specific pathways related to this disease are largely underexplored. The prevailing consensus is that inflammatory pathways contribute to the pathogenesis of this disease, and therefore new research has uncovered how inflammation plays a critical role in the development and progression of MetS. The purpose of this review is to understand the role of major inflammatory mechanisms and their role in MetS. Our review identifies that adipose tissue (AT) contributes to the inflammatory pathways through the release of pro-inflammatory adipokines such as leptin and chemerin and dysregulation of anti-inflammatory adiponectin. Chemokines and cytokines deriving from monocytes are also altered and promote inflammation and insulin resistance. Circulating inflammatory biomarkers including C-reactive protein (CRP), fibrinogen, Serum amyloid A (SAA), cytokines, and chemokines have also been linked to the pathogenesis of MetS. Researchers have identified the significance of CRP levels in predicting future sequelae of MetS such as ASCVD. Mast cells in subcutaneous adipose tissue (SAT) promote both inflammation and fibrosis. Thus, both AT and phagocyte activity define MetS as an inflammatory disorder.
C1 [Reddy, Priya; Lent-Schochet, Daniella; Ramakrishnan, Neeraj; McLaughlin, Matthew; Jialal, Ishwarlal] Calif Northstate Univ, Coll Med, Elk Grove, CA 95757 USA.
   [Jialal, Ishwarlal] VA Med Ctr, Mather, CA 95757 USA.
RP Jialal, I (corresponding author), VA Med Ctr, Sect Clin Chem, 9700 West Taron Dr, Elk Grove, CA 95757 USA.; Jialal, I (corresponding author), Calif North State Univ, Coll Med, Res, 9700 West Taron Dr, Elk Grove, CA 95757 USA.
EM ishwarlal.jialal@cnsu.edu
RI Jialal, Ishwarlal/AAG-6218-2019
FU California Northstate University minigrant
FX California Northstate University minigrant.
CR Al-Shorman A, 2017, SWISS MED WKLY, V147, DOI 10.4414/smw.2017.14446
   ALESSI MC, 1988, THROMB HAEMOSTASIS, V60, P491
   Aroor AR, 2013, METABOLISM, V62, P1543, DOI 10.1016/j.metabol.2013.07.001
   Balta S, 2016, CLIN APPL THROMB-HEM, V22, P405, DOI 10.1177/1076029615569568
   Barchetta I., 2019, J ENDOCRINOL INVEST
   Bhargava P, 2012, BIOCHEM J, V442, P253, DOI 10.1042/BJ20111708
   Bremer A. A., 2010, J CLIN ENDOCR METAB, V314, P1
   Bremer AA, 2013, J OBES, V2013, DOI 10.1155/2013/393192
   Buyukkaya E, 2014, CLIN APPL THROMB-HEM, V20, P159, DOI 10.1177/1076029612459675
   Chen XP, 2014, METAB SYNDR RELAT D, V12, P362, DOI 10.1089/met.2014.0017
   Corrado E, 2010, J ATHEROSCLER THROMB, V17, P1, DOI 10.5551/jat.2600
   D'Alessandris C, 2007, DIABETOLOGIA, V50, P840, DOI 10.1007/s00125-006-0522-y
   Devaraj S, 2009, CURR OPIN LIPIDOL, V20, P182, DOI 10.1097/MOL.0b013e32832ac03e
   Devaraj S, 2009, CLIN CHEM, V55, P229, DOI 10.1373/clinchem.2008.108886
   Fasano A, 2017, AM J CLIN NUTR, V105, P3, DOI 10.3945/ajcn.116.148338
   Fendri S, 1998, METABOLISM, V47, P1372, DOI 10.1016/S0026-0495(98)90307-9
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Ford ES, 2005, DIABETES CARE, V28, P878, DOI 10.2337/diacare.28.4.878
   Fortuño A, 2006, DIABETES, V55, P209, DOI 10.2337/diabetes.55.1.209
   Francisco V., 2019, BIOCH PHARM
   Freeman DJ, 2002, DIABETES, V51, P1596, DOI 10.2337/diabetes.51.5.1596
   Gunn MD, 1997, J IMMUNOL, V158, P376
   Gurung P, 2019, AM J PHYSIOL-ENDOC M, V316, pE504, DOI 10.1152/ajpendo.00462.2018
   Hardy OT, 2013, PEDIATR OBES, V8, pe19, DOI 10.1111/j.2047-6310.2012.00098.x
   Hoseini SM, 2015, METABOLISM, V64, P527, DOI 10.1016/j.metabol.2014.12.009
   Hu E, 1996, J BIOL CHEM, V271, P10697, DOI 10.1074/jbc.271.18.10697
   Hu ZP, 2013, DIABETES RES CLIN PR, V99, P391, DOI 10.1016/j.diabres.2012.11.026
   Imperatore G, 1998, DIABETES CARE, V21, P649, DOI 10.2337/diacare.21.4.649
   Jialal I, 2018, HORM MOL BIOL CLIN I, V33, DOI 10.1515/hmbci-2017-0074
   Jialal I, 2015, ATHEROSCLEROSIS, V241, P130, DOI 10.1016/j.atherosclerosis.2015.04.814
   Jialal I, 2014, EXPERT REV ENDOCRINO, V9, P213, DOI 10.1586/17446651.2014.890046
   Jialal I, 2012, J CLIN ENDOCR METAB, V97, pE1844, DOI 10.1210/jc.2012-2498
   Jialal I, 2012, DIABETES CARE, V35, P900, DOI 10.2337/dc11-2375
   Jung UJ, 2014, INT J MOL SCI, V15, P6184, DOI 10.3390/ijms15046184
   Kamath S, 2003, QJM-INT J MED, V96, P711, DOI 10.1093/qjmed/hcg129
   Kanda H, 2006, J CLIN INVEST, V116, P1494, DOI 10.1172/JCI26498
   Kaur H, 2013, METAB SYNDR RELAT D, V11, P128, DOI 10.1089/met.2012.0179
   KERN PA, 1995, J CLIN INVEST, V95, P2111, DOI 10.1172/JCI117899
   Khan IM, 2016, J CLIN ENDOCR METAB, V101, P4195, DOI 10.1210/jc.2016-2732
   Kim JH, 2017, METAB SYNDR RELAT D, V15, P393, DOI 10.1089/met.2017.0041
   Kraakman MJ, 2015, CELL METAB, V21, P403, DOI 10.1016/j.cmet.2015.02.006
   Lapice E, 2009, DIABETES CARE, V32, P1734, DOI 10.2337/dc09-0176
   Lent-Schochet D, 2018, HORM MOL BIOL CLIN I, V35, DOI 10.1515/hmbci-2018-0015
   Lim PS, 2019, BLOOD PURIFICAT, V47, P28, DOI 10.1159/000492778
   Loughrey BV, 2013, CLIN ENDOCRINOL, V79, P800, DOI 10.1111/cen.12113
   Ma JX, 2010, J ATHEROSCLER THROMB, V17, P486, DOI 10.5551/jat.1529
   Mach F, 1998, ATHEROSCLEROSIS, V137, pS89, DOI 10.1016/S0021-9150(97)00309-2
   Malik N, 1996, J IMMUNOL, V156, P3952
   Moreno-Navarrete JM, 2013, DIABETOLOGIA, V56, P2524, DOI 10.1007/s00125-013-3015-9
   Miller MC, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18102088
   Nakagomi A, 2010, CIRC J, V74, P572, DOI 10.1253/circj.CJ-09-0835
   Natal C, 2008, J CLIN ENDOCR METAB, V93, P2319, DOI 10.1210/jc.2007-2491
   Oki K, 2007, CLIN ENDOCRINOL, V67, P796, DOI 10.1111/j.1365-2265.2007.02966.x
   Onat A, 2009, INT J CARDIOL, V135, P211, DOI 10.1016/j.ijcard.2008.03.054
   Ouchi N, 2010, SCIENCE, V329, P454, DOI 10.1126/science.1188280
   Pagano C, 2006, J CLIN ENDOCR METAB, V91, P3165, DOI 10.1210/jc.2006-0361
   Pahwa R, 2017, J DIABETES COMPLICAT, V31, P810, DOI 10.1016/j.jdiacomp.2017.02.010
   Guzmán-Guzmán IP, 2016, MED CLIN-BARCELONA, V147, P427, DOI 10.1016/j.medcli.2016.06.028
   PICKART LR, 1980, MED HYPOTHESES, V6, P545, DOI 10.1016/0306-9877(80)90108-5
   Ramakrishanan N, 2018, J DIABETES COMPLICAT, V32, P791, DOI 10.1016/j.jdiacomp.2018.05.014
   Reddy P, 2018, J DIABETES COMPLICAT, V32, P465, DOI 10.1016/j.jdiacomp.2018.02.005
   Ridker PM, 1998, CIRCULATION, V97, P2007, DOI 10.1161/01.CIR.97.20.2007
   Ridker PM, 2004, CIRCULATION, V109, P2818, DOI 10.1161/01.CIR.0000132467.45278.59
   Rotter V, 2003, J BIOL CHEM, V278, P45777, DOI 10.1074/jbc.M301977200
   Sage AT, 2012, OBESITY, V20, P748, DOI 10.1038/oby.2011.144
   Schönbeck U, 2001, CELL MOL LIFE SCI, V58, P4, DOI 10.1007/PL00000776
   Schönbeck U, 2001, CIRC RES, V89, P1092, DOI 10.1161/hh2401.101272
   Sefil F, 2014, J INT MED RES, V42, P581, DOI 10.1177/0300060513516944
   Senn JJ, 2002, DIABETES, V51, P3391, DOI 10.2337/diabetes.51.12.3391
   Shim K, 2019, J DIABETES COMPLICAT, V33, P212, DOI 10.1016/j.jdiacomp.2018.12.002
   Shiny A, 2014, DIABETES TECHNOL THE, V16, P524, DOI 10.1089/dia.2013.0264
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Srikanthan K, 2016, INT J MED SCI, V13, P25, DOI 10.7150/ijms.13800
   Surendar J, 2016, J DIABETES COMPLICAT, V30, P1525, DOI 10.1016/j.jdiacomp.2016.08.006
   Tagzirt M, 2014, AM J HYPERTENS, V27, P1096, DOI 10.1093/ajh/hpu021
   Talukdar S, 2012, NAT MED, V18, P1407, DOI 10.1038/nm.2885
   Targonska-Stepniak B, 2014, MEDIAT INFLAMM, V2014, DOI 10.1155/2014/793628
   Tintera J, 2004, PHYSIOL RES, V53, P229, DOI 10.33549/physiolres.930000.53.229
   vandeStolpe A, 1996, THROMB HAEMOSTASIS, V75, P182
   Weisberg SP, 2006, J CLIN INVEST, V116, P115, DOI 10.1172/JCI24335
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Weyer C, 2001, J CLIN ENDOCR METAB, V86, P1930, DOI 10.1210/jc.86.5.1930
   Whitehead JP, 2006, DIABETES OBES METAB, V8, P264, DOI 10.1111/j.1463-1326.2005.00510.x
   Xu JW, 2007, MOL ENDOCRINOL, V21, P564, DOI 10.1210/me.2006-0354
   Yang RZ, 2006, PLOS MED, V3, P884, DOI 10.1371/journal.pmed.0030287
   Yasar Z, 2015, EUR REV MED PHARMACO, V19, P956
   You TJ, 2008, J GERONTOL A-BIOL, V63, P414, DOI 10.1093/gerona/63.4.414
   Zachariah JP, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.116.004974
NR 88
TC 199
Z9 214
U1 3
U2 55
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD SEP
PY 2019
VL 496
BP 35
EP 44
DI 10.1016/j.cca.2019.06.019
PG 10
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA IQ3RX
UT WOS:000480669900006
PM 31229566
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Kasbi-Chadli, F
   Coué, M
   Aguesse, A
   Grit, I
   Souque, T
   Ferchaud-Roucher, V
   Ouguerram, K
AF Kasbi-Chadli, Fatima
   Coue, Marine
   Aguesse, Audrey
   Grit, Isabelle
   Souque, Thomas
   Ferchaud-Roucher, Veronique
   Ouguerram, Khadija
TI Spirulina liquid extract prevents metabolic disturbances and improves
   liver sphingolipids profile in hamster fed a high-fat diet
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Spirulina liquid extract; Glycemia; Dyslipidemia; Oxidative stress;
   Hamster
ID INDUCED INSULIN-RESISTANCE; SKELETAL-MUSCLE; C-PHYCOCYANIN; PLATENSIS
   SUPPLEMENTATION; APOLIPOPROTEIN-B; CERAMIDE; ANTIOXIDANT; OBESITY; ACID;
   DEFICIENCY
AB Purpose Metabolic syndrome is characterized by hyperglycemia, hyperlipemia and exacerbated oxidative stress. The aim of the study was to determine whether Spirulysat(R), a Spirulina liquid extract (SLE) enriched in phycocyanin, would prevent metabolic abnormalities induced by high-fat diet. Methods The effect of acute SLE supplementation on postprandial lipemia and on triton-induced hyperlipidemia was studied in hamster fed control diet (C). The effect of chronic SLE supplementation on lipid content in plasma, liver and aorta, and on glycemia and oxidative stress was studied in hamster fed control (C) or high-fat diet (HF) for two weeks and then treated with SLE for two weeks (CSp and HFSp) or not (C and HF). Results The acute SLE supplementation lowered plasma cholesterol and non-esterified fatty acid concentrations after olive oil gavage (P < 0.05) in CSp, while no effect was observed on triglyceridemia. HFD increased plasma MDA, basal glycemia, triglyceridemia, total plasma cholesterol, VLDL, LDL and HDL cholesterol, ceramide, sphingomyelin and glucosylceramide content in liver in HF compared to C (P < 0.05). SLE did not affect SOD and GPx activities nor total antioxidant status in HFSp group but lowered glycemia, glucoceramide and cholesterol in liver and cholesterol in aorta compared to HF (P < 0.05). SLE also decreased HMGCoA and TGF-beta 1 gene expression in liver (P < 0.05) and tended to lower G6Pase (P = 0.068) gene expression in HFSp compared to HF. Conclusion Although 2-week SLE supplementation did not affect oxidative stress, it protected from hyperglycemia and lipid accumulation in liver and aorta suggesting a protective effect against metabolic syndrome.
C1 [Kasbi-Chadli, Fatima; Coue, Marine; Aguesse, Audrey; Grit, Isabelle; Souque, Thomas; Ferchaud-Roucher, Veronique; Ouguerram, Khadija] Univ Nantes, INRAe UMR1280 PhAN, Physiopathol Nutr Adaptat, CHU Hotel Dieu,IMAD,CRNH Ouest, 1 Pl Alexis Ricordeau, F-44093 Nantes 01, France.
C3 Nantes Universite; CHU de Nantes; INRAE
RP Kasbi-Chadli, F (corresponding author), Univ Nantes, INRAe UMR1280 PhAN, Physiopathol Nutr Adaptat, CHU Hotel Dieu,IMAD,CRNH Ouest, 1 Pl Alexis Ricordeau, F-44093 Nantes 01, France.
EM fatima.chadli-kasbi@univ-nantes.fr; marine.coue@univ-nantes.fr;
   audrey.aguesse@univ-nantes.fr; isabelle.grit@univ-nantes.fr;
   thomas.souquet@etu.univ-nantes.fr;
   veronique.ferchaud-roucher@univ-nantes.fr;
   khadija.ouguerram@univ-nantes.fr
RI Coué, Marine/AAL-3942-2021
OI FERCHAUD-ROUCHER, Veronique/0000-0001-6809-1488; Coue,
   Marine/0000-0001-8435-7143
CR Adams JM, 2004, DIABETES, V53, P25, DOI 10.2337/diabetes.53.1.25
   Bauer J, 2014, BRIT J PHARMACOL, V171, P3115, DOI 10.1111/bph.12677
   Bauters D, 2016, LIVER INT, V36, P1848, DOI 10.1111/liv.13181
   BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911
   Chavez JA, 2003, J BIOL CHEM, V278, P10297, DOI 10.1074/jbc.M212307200
   Chen TF, 2008, J AGR FOOD CHEM, V56, P4352, DOI 10.1021/jf073399k
   CLEMENT G, 1967, J SCI FOOD AGR, V18, P497, DOI 10.1002/jsfa.2740181101
   Coué M, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010194
   Deng RT, 2010, CARDIOVASC THER, V28, pe33, DOI 10.1111/j.1755-5922.2010.00200.x
   Deng Y, 2018, INT J MOL SCI
   Dillard A, 2010, NUTR METAB, V7, DOI 10.1186/1743-7075-7-89
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Finamore A, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/3247528
   Hamedifard Z, 2019, PHYTOTHER RES, V33, P2609, DOI 10.1002/ptr.6441
   Han LK, 2006, YAKUGAKU ZASSHI, V126, P43, DOI 10.1248/yakushi.126.43
   Heo MG, 2018, FOOD FUNCT, V9, P4906, DOI 10.1039/c8fo00986d
   Holland WL, 2007, NUTR REV, V65, pS39, DOI [10.1111/j.1753-4887.2007.tb00327.x, 10.1301/nr.2007.jun.S39-S46]
   Jackson KG, 2012, ATHEROSCLEROSIS, V220, P22, DOI 10.1016/j.atherosclerosis.2011.08.012
   JeBailey L, 2007, DIABETES, V56, P394, DOI 10.2337/db06-0823
   Kasbi-Chadli F, 2016, EUR J NUTR, V55, P589, DOI 10.1007/s00394-015-0879-0
   Le Barz M, 2020, BIOCHIMIE, V169, P133, DOI 10.1016/j.biochi.2019.10.003
   Li XD, 2011, PROTEIN CELL, V2, P189, DOI 10.1007/s13238-011-1016-3
   Marinho R, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/s13098-015-0064-x
   Mazokopakis EE, 2014, ANN GASTROENTEROL, V27, P387
   Millar JS, 2002, ARTERIOSCL THROM VAS, V22, P989, DOI 10.1161/01.ATV.0000018304.30943.06
   Muga MA, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-470
   Nagaoka S, 2005, J NUTR, V135, P2425, DOI 10.1093/jn/135.10.2425
   NAKAYA N, 1988, NUTR REP INT, V37, P1329
   Nasirian F, 2018, DIABET METAB SYND OB, V11, P375, DOI 10.2147/DMSO.S172104
   Ngo-Matip ME, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-191
   Ou Y, 2013, PHARM BIOL, V51, P539, DOI 10.3109/13880209.2012.747545
   Ou Y, 2012, ENVIRON TOXICOL PHAR, V34, P721, DOI 10.1016/j.etap.2012.09.016
   Parikh Panam, 2001, J Med Food, V4, P193, DOI 10.1089/10966200152744463
   Powell DJ, 2004, BIOCHEM J, V382, P619, DOI 10.1042/BJ20040139
   Rao RP, 2013, J LIPIDS, V2013, DOI 10.1155/2013/178910
   Ren ZH, 2018, FOOD FUNCT, V9, P2829, DOI 10.1039/c8fo00257f
   Rodríguez-Hernández A, 2001, LIFE SCI, V69, P1029, DOI 10.1016/S0024-3205(01)01185-7
   Romay C, 2003, CURR PROTEIN PEPT SC, V4, P207, DOI 10.2174/1389203033487216
   Sánchez-García A, 2018, PHARMACOL RES, V135, P144, DOI 10.1016/j.phrs.2018.08.008
   Schmitz-Peiffer C, 1999, J BIOL CHEM, V274, P24202, DOI 10.1074/jbc.274.34.24202
   SCHOTZ MC, 1957, AM J PHYSIOL, V188, P399, DOI 10.1152/ajplegacy.1957.188.2.399
   Simon J, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21010040
   Siri P, 2001, J BIOL CHEM, V276, P46064, DOI 10.1074/jbc.M108909200
   Soofi A, 2017, J BIOL CHEM, V292, P9051, DOI 10.1074/jbc.M116.771428
   Straczkowski M, 2004, DIABETES, V53, P1215, DOI 10.2337/diabetes.53.5.1215
   TURINSKY J, 1990, J BIOL CHEM, V265, P7933
   Vadiraja BB, 1998, BIOCHEM BIOPH RES CO, V249, P428, DOI 10.1006/bbrc.1998.9149
   Vidé J, 2018, FOOD FUNCT, V9, P6166, DOI [10.1039/c8fo02037j, 10.1039/C8FO02037J]
   Vidé J, 2015, NUTRITION, V31, P1148, DOI 10.1016/j.nut.2015.03.014
   Wilkerson JL, 2019, EBIOMEDICINE, V41, P3, DOI 10.1016/j.ebiom.2019.02.004
   Yousefi R, 2018, COMPLEMENT THER MED, V40, P106, DOI 10.1016/j.ctim.2018.08.003
NR 51
TC 6
Z9 6
U1 1
U2 12
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD DEC
PY 2021
VL 60
IS 8
BP 4483
EP 4494
DI 10.1007/s00394-021-02589-x
EA JUN 2021
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA WS2TS
UT WOS:000659819600001
PM 34110469
DA 2025-06-11
ER

PT J
AU Martínez-Hernández, A
   Córdova, EJ
   Rosillo-Salazar, O
   García-Ortíz, H
   Contreras-Cubas, C
   Islas-Andrade, S
   Revilla-Monsalve, C
   Salas-Labadía, C
   Orozco, L
AF Martinez-Hernandez, Angelica
   Cordova, Emilio J.
   Rosillo-Salazar, Oscar
   Garcia-Ortiz, Humberto
   Contreras-Cubas, Cecilia
   Islas-Andrade, Sergio
   Revilla-Monsalve, Cristina
   Salas-Labadia, Consuelo
   Orozco, Lorena
TI Association of HMOX1 and NQO1 Polymorphisms with Metabolic
   Syndrome Components
SO PLOS ONE
LA English
DT Article
ID HEME OXYGENASE-1 GENE; OXIDATIVE STRESS; CARBON-MONOXIDE;
   NAD(P)H-QUINONE OXIDOREDUCTASE-1; ENDOTHELIAL DYSFUNCTION;
   MICROSATELLITE REPEATS; C609T POLYMORPHISM; NATIONAL-HEALTH; IRON
   STATUS; PROMOTER
AB Metabolic syndrome (MetS) is among the most important public health problems worldwide, and is recognized as a major risk factor for various illnesses, including type 2 diabetes mellitus, obesity, and cardiovascular diseases. Recently, oxidative stress has been suggested as part of MetS aetiology. The heme oxygenase 1 (HMOX1) and NADH: quinone oxidoreductase 1 (NQO1) genes are crucial mediators of cellular defence against oxidative stress. In the present study, we analysed the associations of HMOX1 (GT)n and NQO1 C609T polymorphisms with MetS and its components. Our study population comprised 735 Mexican Mestizos unrelated volunteers recruited from different tertiary health institutions from Mexico City. In order to know the HMOX1 (GT) n and NQO1 C609T allele frequencies in Amerindians, we included a population of 241 Amerindian native speakers. Their clinical and demographic data were recorded. The HMOX1 (GT) n polymorphism was genotyped using PCR and fluorescence technology. NQO1 C609T polymorphism genotyping was performed using TaqMan probes. Short allele (<25 GT repeats) of the HMOX1 polymorphism was associated with high systolic and diastolic blood pressure, and the T allele of the NQO1 C609T polymorphism was associated with increased triglyceride levels and decreased HDL-c levels, but only in individuals with MetS. This is the first study to analyse the association between MetS and genes involved in oxidative stress among Mexican Mestizos. Our data suggest that polymorphisms of HMOX1 and NQO1 genes are associated with a high risk of metabolic disorders, including high systolic and diastolic blood pressure, hypertriglyceridemia, and low HDL-c levels in Mexican Mestizo individuals.
C1 [Martinez-Hernandez, Angelica; Cordova, Emilio J.; Rosillo-Salazar, Oscar; Garcia-Ortiz, Humberto; Contreras-Cubas, Cecilia; Orozco, Lorena] Inst Nacl Med Genom, SS, Immunogen & Metab Dis Lab, Mexico City, DF, Mexico.
   [Islas-Andrade, Sergio; Revilla-Monsalve, Cristina] IMSS, Ctr Med Nacl Siglo 21, Med Res Unit Metab Dis, Mexico City, DF, Mexico.
   [Salas-Labadia, Consuelo] Inst Nacl Pediat, SS, Dept Human Genet, Tissue Culture Lab, Mexico City, DF, Mexico.
C3 Instituto Nacional de Medicina Genomica; Instituto Mexicano del Seguro
   Social
RP Orozco, L (corresponding author), Inst Nacl Med Genom, SS, Immunogen & Metab Dis Lab, Mexico City, DF, Mexico.
EM lorozco@inmegen.gob.mx
RI Revilla-Monsalve, Cristina/ABG-6663-2021
OI Rosillo Salazar, Oscar Daniel/0000-0002-6393-2409; Orozco,
   Lorena/0000-0002-5801-9180; Revilla Monsalve, Maria
   Cristina/0000-0002-6202-1160; Garcia-Ortiz,
   Humberto/0000-0002-0453-980X; Martinez-H, Angelica/0000-0001-9883-2988;
   salas, consuelo/0000-0002-3301-7357
CR Abraham NG, 2005, FREE RADICAL BIO MED, V39, P1, DOI 10.1016/j.freeradbiomed.2005.03.010
   Arredondo M, 2007, AM J CLIN NUTR, V86, P1347, DOI 10.1093/ajcn/86.5.1347
   Arredondo M, 2011, BIOL TRACE ELEM RES, V143, P625, DOI 10.1007/s12011-010-8895-7
   Bagul PK, 2012, PHARMACOL RES, V66, P260, DOI 10.1016/j.phrs.2012.05.003
   Córdova EJ, 2012, CLIN EXP RHEUMATOL, V30, P297
   Córdova EJ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0088069
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Funke C, 2009, J NEURAL TRANSM, V116, P853, DOI 10.1007/s00702-009-0237-6
   Gaikwad A, 2001, J BIOL CHEM, V276, P22559, DOI 10.1074/jbc.M101053200
   Gregorek AC, 2013, BIOCHEM GENET, V51, P482, DOI 10.1007/s10528-013-9579-8
   Han SJ, 2009, MOL GENET METAB, V97, P85, DOI 10.1016/j.ymgme.2009.01.012
   Hassan N, 2013, N-S ARCH PHARMACOL, V386, P217, DOI 10.1007/s00210-012-0822-3
   Hong CC, 2007, CANCER EPIDEM BIOMAR, V16, P1784, DOI 10.1158/1055-9965.EPI-07-0247
   Hwang JH, 2009, DIABETES, V58, P965, DOI 10.2337/db08-1183
   Idriss NK, 2008, J AM COLL CARDIOL, V52, P971, DOI 10.1016/j.jacc.2008.06.019
   Ilkun O, 2013, CURR PHARM DESIGN, V19, P4806, DOI 10.2174/1381612811319270003
   Islam T, 2008, AM J RESP CRIT CARE, V177, P388, DOI 10.1164/rccm.200706-863OC
   Javanmard SH, 2012, MOL BIOL REP, V39, P3355, DOI 10.1007/s11033-011-1105-7
   Johnson FK, 2006, AM J PHYSIOL-REG I, V290, pR601, DOI 10.1152/ajpregu.00308.2005
   Katana EP, 2011, CHINESE MED J-PEKING, V124, P3408, DOI 10.3760/cma.j.issn.0366-6999.2011.20.036
   Kim DH, 2008, J PHARMACOL EXP THER, V325, P833, DOI 10.1124/jpet.107.135285
   Král A, 2011, FOLIA BIOL-PRAGUE, V57, P182
   Leffler CW, 1999, AM J PHYSIOL-HEART C, V276, pH1641, DOI 10.1152/ajpheart.1999.276.5.H1641
   Leiva E, 2013, BIOL TRACE ELEM RES, V151, P1, DOI 10.1007/s12011-012-9525-3
   Martin NJ, 2009, MUTAT RES-GEN TOX EN, V674, P93, DOI 10.1016/j.mrgentox.2008.09.009
   Mustafa S, 2008, J VASC SURG, V47, P566, DOI 10.1016/j.jvs.2007.09.060
   Ono K, 2003, J HYPERTENS, V21, P1497, DOI 10.1097/00004872-200308000-00013
   Palmieri VO, 2006, J NUTR, V136, P3022, DOI 10.1093/jn/136.12.3022
   Palming J, 2007, J CLIN ENDOCR METAB, V92, P2346, DOI 10.1210/jc.2006-2476
   Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795
   Ramprasath T, 2012, MOL CELL BIOCHEM, V361, P143, DOI 10.1007/s11010-011-1098-5
   Rojas R, 2010, SALUD PUBLICA MEXICO, V52, pS11, DOI 10.1590/S0036-36342010000700004
   Rojas-Martínez R, 2012, SALUD PUBLICA MEXICO, V54, P13
   Rueda B, 2007, ARTHRITIS RHEUM-US, V56, P3953, DOI 10.1002/art.23048
   Saraiva RM, 2007, NITRIC OXIDE-BIOL CH, V16, P331, DOI 10.1016/j.niox.2006.12.001
   Sarbia M, 2003, INT J CANCER, V107, P381, DOI 10.1002/ijc.11430
   Sheu CC, 2009, INTENS CARE MED, V35, P1343, DOI 10.1007/s00134-009-1504-6
   Teran FJ, 2005, AM J PHYSIOL-REG I, V288, pR615, DOI 10.1152/ajpregu.00123.2004
   Vázquez-Armenta G, 2013, TOHOKU J EXP MED, V231, P201, DOI 10.1620/tjem.231.201
   Wan Hua-ying, 2005, Zhongguo Yi Xue Ke Xue Yuan Xue Bao, V27, P285
   Wang GY, 2006, BIOCHEM BIOPH RES CO, V341, P310, DOI 10.1016/j.bbrc.2005.12.195
   Wu MM, 2011, ATHEROSCLEROSIS, V219, P704, DOI 10.1016/j.atherosclerosis.2011.08.047
   Zhang JH, 2003, CARCINOGENESIS, V24, P905, DOI 10.1093/carcin/bgg019
   Zierold KM, 2004, AM J PUBLIC HEALTH, V94, P1936, DOI 10.2105/AJPH.94.11.1936
NR 44
TC 23
Z9 26
U1 0
U2 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 1
PY 2015
VL 10
IS 5
AR e0123313
DI 10.1371/journal.pone.0123313
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CH2XA
UT WOS:000353887100019
PM 25933176
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Hackett, G
   Cole, N
   Bhartia, M
   Kennedy, D
   Raju, J
   Wilkinson, P
AF Hackett, Geoffrey
   Cole, Nigel
   Bhartia, Mithun
   Kennedy, David
   Raju, Jessie
   Wilkinson, Peter
TI Testosterone Replacement Therapy with Long-Acting Testosterone
   Undecanoate Improves Sexual Function and Quality-of-Life Parameters vs.
   Placebo in a Population of Men with Type 2 Diabetes
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE AMSAgeing Male Symptom Score; IIEFInternational Index of Erectile
   Function; HADSHospital Anxiety and Depression Scale; TDStestosterone
   deficiency syndrome; TRTtestosterone replacement therapy; LOHlate-onset
   hypogonadism; T2Dtype 2 diabetes; TUTestosterone Undecanoate;
   NICENational Institute for Health and Clinical Excellence; QoFquality
   outcome framework
ID RANDOMIZED CONTROLLED-TRIAL; LATE-ONSET HYPOGONADISM; LOW SERUM
   TESTOSTERONE; ERECTILE DYSFUNCTION; AGING MEN; OLDER MEN; METABOLIC
   SYNDROME; DEPRESSION; METAANALYSIS; SUPPLEMENTATION
AB Introduction Sexual dysfunction, particularly erectile dysfunction (ED), is common in men with type 2 diabetes, occurring in up to 75% of cases. The prevalence of hypogonadism is also high in men with diabetes and low testosterone is associated with both sexual dysfunction and a reduced response to oral therapy for ED. Aim This study aimed to determine the effect of testosterone replacement with long-acting Testosterone Undecanoate (TU) on sexual function, mood and quality of life vs. placebo over a treatment period of 30 weeks followed by 52 weeks of open-label medication. The study was conducted in a primary care population of men with type 2 diabetes attending their primary care physician for routine visits. Methods The male diabetic populations of seven general practices were screened at routine diabetes visits to detect symptomatic men with total testosterone levels of 12nmol/L or less or with free testosterones of 250pmol/L or less. Two hundred eleven men were screened. A double-blind placebo-controlled study was conducted in 199 men with type 2 diabetes and hypogonadism treated for 30 weeks with either 1,000mg of TU or matching placebo followed by 52-week open-label follow on. Main Outcome Measures The primary outcome measure, International Index of Erectile Function (IIEF), was used to evaluate sexual dysfunction, and the Ageing Male Symptom (AMS), Hospital Anxiety and Depression Scale, and Global Efficacy Question were used as secondary outcome measures to assess mood and self-reported quality of life. Results Testosterone replacement therapy with long-acting TU improved all domains of sexual function at 30 weeks (erectile function [EF], P=0.005; intercourse satisfaction, P=0.015; sexual desire, P=0.001; overall satisfaction, P=0.05; and orgasm, P=0.04), with benefit as early as 6 weeks. Improvements in AMS score were significant in men without depression (P=0.02) and the presence of depression at baseline was associated with marked reduction in response to both sexual function and psychological scores. All responses in sexual function continued to improve significantly up to 18 months with an improvement in EF score of 4.31 from baseline. In a small cohort of 35 men taking phosphodiesterase type 5 inhibitors, there was no change during the double-blind phase but a nine-point improvement in EF domain during 52-week open-label treatment. After 30 weeks, 46% vs. 17% of patients on active therapy vs. placebo felt that the treatment had improved their health, reaching 70% after open-label therapy. Less obese and older patients responded better to testosterone therapy. There were no significant adverse events. Conclusion TU significantly improved all domains of the IIEF and patient reported quality of life at 30 weeks and more significantly after 52-week open-label extension. Improvement was most marked in less obese patient and those without coexisting depression. In men with type 2 diabetes, trials of therapy may need to be given for much longer than 3-6 months suggested in current guidelines.
C1 [Hackett, Geoffrey; Bhartia, Mithun; Kennedy, David; Raju, Jessie] Good Hope Hosp, Sutton Coldfield B75 7RR, England.
   [Cole, Nigel] Cloisters Practice, Lichfield, England.
   [Wilkinson, Peter] Wilkinson Associates, Radnor, Herts, England.
C3 Heart of England NHS Foundation Trust; Good Hope Hospital
RP Hackett, G (corresponding author), Good Hope Hosp, Sutton Coldfield B75 7RR, England.
EM Geoff.hackett@virgin.net
FU Bayer
FX This was an investigator-initiated and sponsored study with no influence
   on the intellectual content. Bayer supplied medication and financial
   support for investigator costs.
CR Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   Bacon CG, 2002, DIABETES CARE, V25, P1458, DOI 10.2337/diacare.25.8.1458
   Basaria S, 2012, NEW ENGL J MED, V363, P109
   Bhasin S, 2006, J CLIN ENDOCR METAB, V91, P1995, DOI 10.1210/jc.2005-2847
   Calof OM, 2005, J GERONTOL A-BIOL, V60, P1451, DOI 10.1093/gerona/60.11.1451
   Ciechanowski PS, 2000, ARCH INTERN MED, V160, P3278, DOI 10.1001/archinte.160.21.3278
   Corona G, 2011, J SEX MED, V8, P639, DOI 10.1111/j.1743-6109.2010.02200.x
   de Groot M, 2001, PSYCHOSOM MED, V63, P619, DOI 10.1097/00006842-200107000-00015
   Dhindsa S, 2004, J CLIN ENDOCR METAB, V89, P5462, DOI 10.1210/jc.2004-0804
   Dinan TG, 2009, CURR OPIN PSYCHIATR, V22, P32, DOI 10.1097/YCO.0b013e328315a561
   Eardley I, 2006, EUR UROL, V50, P31, DOI 10.1016/j.eururo.2005.12.005
   Emmelot-Vonk MH, 2009, INT J IMPOT RES, V21, P129, DOI 10.1038/ijir.2009.5
   Giltay EJ, 2010, J SEX MED, V7, P2572, DOI 10.1111/j.1743-6109.2010.01859.x
   Hackett G., 2009, Diabetes Vascular Disease, V9, P226, DOI [DOI 10.1177/1474651409342635, 10.1177/1474651409342635]
   Hackett G, 2008, J SEX MED, V5, P1841, DOI 10.1111/j.1743-6109.2008.00773.x
   Heinemann LAJ., 1999, Aging Male, V2, P105, DOI DOI 10.3109/13685539909003173
   Hintikka J, 2009, J SEX MED, V6, P2049, DOI 10.1111/j.1743-6109.2009.01299.x
   Home P, 2008, BRIT MED J, V336, P1306, DOI 10.1136/bmj.39560.442095.AD
   Huhtaniemi IT, 2012, EUR J ENDOCRINOL, V166, P983, DOI 10.1530/EJE-11-1051
   Isidori AM, 2005, CLIN ENDOCRINOL, V63, P381, DOI 10.1111/j.1365-2265.2005.02350.x
   Jones TH, 2011, DIABETES CARE, V34, P828, DOI 10.2337/dc10-1233
   Kalinchenko SY, 2010, CLIN ENDOCRINOL, V73, P602, DOI 10.1111/j.1365-2265.2010.03845.x
   Kapoor D, 2007, DIABETES CARE, V30, P911, DOI 10.2337/dc06-1426
   Khaw KT, 2007, CIRCULATION, V116, P2694, DOI 10.1161/CIRCULATIONAHA.107.719005
   Khera M, 2011, J SEX MED, V8, P3204, DOI 10.1111/j.1743-6109.2011.02436.x
   Leibowitz RL, 2010, BJU INT, V105, P1397, DOI 10.1111/j.1464-410X.2009.08980.x
   Marberger M, 2011, BJU INT, V108, P256, DOI 10.1111/j.1464-410X.2010.09766.x
   Marks LS, 2006, JAMA-J AM MED ASSOC, V296, P2351, DOI 10.1001/jama.296.19.2351
   National Health Service, QUAL OUTC FRAM DIAB
   Oh JY, 2002, DIABETES CARE, V25, P55, DOI 10.2337/diacare.25.1.55
   Papelbaum M, 2011, DIABETOL METAB SYNDR, V3, DOI 10.1186/1758-5996-3-26
   Parsons JK, 2010, CURR BLADDER DYSFUNC, V5, P212, DOI 10.1007/s11884-010-0067-2
   Pechersky AV, 2002, INT J ANDROL, V25, P119, DOI 10.1046/j.1365-2605.2002.00335.x
   Pope HG, 2010, J CLIN PSYCHOPHARM, V30, P126, DOI 10.1097/JCP.0b013e3181d207ca
   Price DW, 2013, DIABETES CARE, V36, P216, DOI 10.2337/dc12-0293
   Rizvi SJ, 2010, J SEX MED, V7, P816, DOI 10.1111/j.1743-6109.2009.01504.x
   Rosen RC, 1997, UROLOGY, V49, P822, DOI 10.1016/S0090-4295(97)00238-0
   Saad F, 2011, EUR J ENDOCRINOL, V165, P675, DOI 10.1530/EJE-11-0221
   Schubert M, 2004, J CLIN ENDOCR METAB, V89, P5429, DOI 10.1210/jc.2004-0897
   Shabsigh R, 2009, INT J IMPOT RES, V21, P9, DOI 10.1038/ijir.2008.31
   Shabsigh R, 2004, J UROLOGY, V172, P658, DOI 10.1097/01.ju.0000132389.97804.d7
   Shigehara K, 2011, AGING MALE, V14, P53, DOI 10.3109/13685538.2010.518178
   Shores MM, 2004, ARCH GEN PSYCHIAT, V61, P162, DOI 10.1001/archpsyc.61.2.162
   Shores MM, 2006, ARCH INTERN MED, V166, P1660, DOI 10.1001/archinte.166.15.1660
   Spitzer M, 2012, ANN INTERN MED, V157, P681, DOI 10.7326/0003-4819-157-10-201211200-00004
   Vermeulen A, 1999, J CLIN ENDOCR METAB, V84, P3666, DOI 10.1210/jc.84.10.3666
   Vickers MA, 2002, INT J IMPOT RES, V14, P466, DOI 10.1038/sj.ijir.3900910
   Wang C, 2009, EUR UROL, V55, P121, DOI 10.1016/j.eururo.2008.08.033
   Wu FCW, 2010, NEW ENGL J MED, V363, P123, DOI 10.1056/NEJMoa0911101
   Yassin AA, 2006, J SEX MED, V3, P727, DOI 10.1111/j.1743-6109.2006.00267.x
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
   Zitzmann M, 2013, J SEX MED, V10, P579, DOI 10.1111/j.1743-6109.2012.02853.x
NR 52
TC 131
Z9 140
U1 0
U2 18
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD JUN
PY 2013
VL 10
IS 6
BP 1612
EP 1627
DI 10.1111/jsm.12146
PG 16
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 157DZ
UT WOS:000319877400019
PM 23551886
DA 2025-06-11
ER

PT J
AU Aisya, RW
   Nugroho, HSKH
   Widyastiti, NS
   Tjahjono, K
   Afifah, DN
AF Aisya, Rizki Widyan
   Nugroho, H. S. K. Heri
   Widyastiti, Nyoman Suci
   Tjahjono, Kusmiyati
   Afifah, Diana Nur
TI The Effectiveness of Aloe-based Drink in Reducing Glycated Albumin and
   Insulin Resistance of Metabolic Syndrome: A Randomized Clinical Trial
SO CURRENT RESEARCH IN NUTRITION AND FOOD SCIENCE
LA English
DT Article
DE Aloe-Based Drink; Glycated Albumin; Insulin Resistance; Metabolic
   Syndrome
ID OXIDATIVE STRESS; ANTIOXIDANT; DISEASE
AB Insulin resistance (IR) has an important role in the pathology that forms the metabolic syndrome (MetS). Glycated Albumin (GA) has a role as an index of glycemic control associated with MetS. Aloe vera (Aloe barbadensis Miller) is a plant that has anti-diabetic and anti-hypercholesterolemic function. This study aims to investigate the effect of Aloe-based drink on GA and IR in MetS. This study was a true experimental using pre-post randomized control group design. Thirty-eight MetS subjects were divided into two groups: treatment group (n=19) which was provided by 165 g/d of Aloe-based drink for 4 weeks; and the control group (n=19). Both groups were given education regarding of management of MetS. GA was measured by using an ELISA method and IR calculated by HOMA-IR of both groups and statistically analyzed at baseline and the end of treatment. The data were analyzed using paired t-test and independent t-test. At the end of the study, the treatment group showed reduction of GA and HOMA-IR statistically significant (GA=-4.32.35%;p<0.001; HOMA-IR=-1.6 1.87; p=0.001). Compared to control group, the change of GA and HOMA-IR in intervention group were also significantly different (p<0.001; p<0.001). Aloe-based drink was proven to reduce GA and IR in the MetS.
C1 [Aisya, Rizki Widyan; Afifah, Diana Nur] Diponegoro Univ, Dept Nutr Sci, Fac Med, Semarang, Indonesia.
   [Nugroho, H. S. K. Heri] Diponegoro Univ, Dept Internal Med, Fac Med, Semarang, Indonesia.
   [Widyastiti, Nyoman Suci] Diponegoro Univ, Dept Clin Pathol, Fac Med, Semarang, Indonesia.
   [Tjahjono, Kusmiyati] Diponegoro Univ, Dept Biochem, Fac Med, Semarang, Indonesia.
C3 Diponegoro University; Diponegoro University; Diponegoro University;
   Diponegoro University
RP Afifah, DN (corresponding author), Diponegoro Univ, Dept Nutr Sci, Fac Med, Semarang, Indonesia.
EM d.nurafifah.dna@fk.undip.ac.id
RI Afifah, Diana Nur/AAK-7171-2020; Widyastiti, Nyoman Suci/GQO-8245-2022
OI Nugroho, Heri/0000-0001-7875-6973
CR Aydin S, 2014, NUTRITION, V30, P1, DOI 10.1016/j.nut.2013.05.013
   Cardenas-Ibarra L., 2017, Clinical Nutrition Experimental, V14, P1, DOI 10.1016/j.yclnex.2017.05.003
   Chan CL, 2017, PEDIATR DIABETES, V18, P470, DOI 10.1111/pedi.12422
   Choi HC, 2013, NUTRITION, V29, P1110, DOI 10.1016/j.nut.2013.02.015
   Devaraj S, 2013, METAB SYNDR RELAT D, V11, P35, DOI 10.1089/met.2012.0066
   Ghezzi AC, 2012, DIABETOL METAB SYNDR, V4, DOI 10.1186/1758-5996-4-16
   Goldin A, 2006, CIRCULATION, V114, P597, DOI 10.1161/CIRCULATIONAHA.106.621854
   Habib SA, 2015, ADV MED SCI-POLAND, V60, P179, DOI 10.1016/j.advms.2015.02.002
   Ikezaki H, 2015, METABOLISM, V64, P698, DOI 10.1016/j.metabol.2015.03.003
   Kammoun M, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-30
   Kang MC, 2014, CARBOHYD POLYM, V99, P365, DOI 10.1016/j.carbpol.2013.07.091
   Kurtoglu Selim, 2010, J Clin Res Pediatr Endocrinol, V2, P100, DOI 10.4274/jcrpe.v2i3.100
   Oladosu WO, 2020, INT J APPL BASIC MED, V10, P252, DOI 10.4103/ijabmr.IJABMR_118_19
   Panahi Y, 2015, CLIN NUTR, V34, P1101, DOI 10.1016/j.clnu.2014.12.019
   Patche J, 2016, FREE RADICAL BIO MED, V102, P1
   Prasad M, 2015, DIABETES METAB SYND, V9, P38, DOI 10.1016/j.dsx.2014.04.025
   Qi WW, 2014, CELL STRESS CHAPERON, V19, P105, DOI 10.1007/s12192-013-0438-7
   Radha Maharjan H, 2015, J Tradit Complement Med, V5, P21, DOI 10.1016/j.jtcme.2014.10.006
   Raghav A, 2014, DIABETES METAB SYND, V8, P245, DOI 10.1016/j.dsx.2014.09.017
   Riyanto Wariyah C., 2012, AGRITECH, V32, P73
   Salah F, 2017, IND CROP PROD, V103, P13, DOI 10.1016/j.indcrop.2017.03.031
   Sanchez-Machado DI, 2017, TRENDS FOOD SCI TECH, V61, P94, DOI 10.1016/j.tifs.2016.12.005
   Sihombing M., 2015, Penelitian Gizi Dan Makanan, V38, P21, DOI [10.22435/pgm.v38i1.4418.21-30, DOI 10.22435/PGM.V38I1.4418.21-30]
   Viscogliosi G, 2012, METAB SYNDR RELAT D, V10, P358, DOI 10.1089/met.2012.0043
   WHO, 2014, GLOBAL STATUS REPORT ON VIOLENCE PREVENTION 2014, P1
   Wong Y, 2016, J ENDOUROL, V30, P246, DOI 10.1089/end.2015.0567
   Yazdanpanah S, 2017, CRIT REV CL LAB SCI, V54, P219, DOI 10.1080/10408363.2017.1299684
NR 27
TC 1
Z9 1
U1 0
U2 1
PU ENVIRO RESEARCH PUBLISHERS
PI BHOPAL
PA 14 GREEN HOUSE, PRINCE COLONY, SHAHJAHANABAD, BHOPAL, MADHYA PRADESH 462
   001, INDIA
SN 2347-467X
EI 2322-0007
J9 CURR RES NUTR FOOD S
JI Curr. Res. Nutr. Food Sci.
PD AUG
PY 2022
VL 10
IS 2
BP 566
EP 574
DI 10.12944/CRNFSJ.10.2.13
PG 9
WC Food Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Food Science & Technology
GA 6G0SA
UT WOS:000884469700011
OA gold
DA 2025-06-11
ER

PT J
AU Archontogeorgis, K
   Voulgaris, A
   Papanas, N
   Nena, E
   Xanthoudaki, M
   Pataka, A
   Schiza, SE
   Rizzo, M
   Froudarakis, ME
   Steiropoulos, P
AF Archontogeorgis, Kostas
   Voulgaris, Athanasios
   Papanas, Nikolaos
   Nena, Evangelia
   Xanthoudaki, Maria
   Pataka, Athanasia
   Schiza, Sophia E.
   Rizzo, Manfredi
   Froudarakis, Marios E.
   Steiropoulos, Paschalis
TI Metabolic Syndrome in Patients with Coexistent Obstructive Sleep Apnea
   Syndrome and Chronic Obstructive Pulmonary Disease (Overlap Syndrome)
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE chronic obstructive pulmonary disease; metabolic syndrome; obstructive
   sleep apnea syndrome; overlap syndrome; obesity
ID OXIDATIVE STRESS; COMORBIDITIES; ASSOCIATION; COPD; CONSEQUENCES;
   PREVALENCE; PREDICTORS; COMPONENTS; OBESITY; LUNG
AB Background: Evidence suggests that metabolic syndrome (MetS) is highly prevalent in patients with obstructive sleep apnea syndrome (OSAS) and chronic obstructive pulmonary disease (COPD). However, data on the prevalence of MetS in patients having both OSAS and COPD, or overlap syndrome (OS), are scarce. The aim of this study was to evaluate the prevalence and identify predictors of MetS in patients with OS.
   Methods: MetS was evaluated in consecutive patients who were diagnosed with OS by polysomnography and pulmonary function testing.
   Results: A total of 163 subjects (138 males and 25 females) were included. MetS was present in 38% of OS patients. Patients were divided into group A (OS without MetS group: 101 patients) and group B (OS with MetS group: 62 patients). Groups were similar in terms of pulmonary function and sleep parameters. In group B, abdominal obesity was the most prevalent component of MetS (100%), followed by hypertension (82.3%), hypertriglyceridemia (72.6%), and hyperglycemia (51.6%). Age (P = 0.009) and body mass index (P = 0.029) were independent predictors of MetS in patients with OS.
   Conclusions: An increased prevalence of MetS was observed in a group of patients with OS. Early identification and treatment of MetS may play a significant role in prevention of complications related to OS.
C1 [Archontogeorgis, Kostas; Voulgaris, Athanasios; Steiropoulos, Paschalis] Democritus Univ Thrace, MSc Program Sleep Med, Med Sch, Alexandroupolis, Greece.
   [Voulgaris, Athanasios; Xanthoudaki, Maria; Froudarakis, Marios E.; Steiropoulos, Paschalis] Democritus Univ Thrace, Dept Pneumonol, Med Sch, Alexandroupolis 68100, Greece.
   [Papanas, Nikolaos] Democritus Univ Thrace, Dept Internal Med 2, Med Sch, Alexandroupolis, Greece.
   [Nena, Evangelia] Democritus Univ Thrace, Lab Hyg & Environm Protect, Med Sch, Alexandroupolis, Greece.
   [Pataka, Athanasia] Aristotle Univ Thessaloniki, G Papanikolaou Gen Hosp, Resp Failure Unit, Thessaloniki, Greece.
   [Schiza, Sophia E.] Univ Crete, Med Sch, Dept Resp Med, Sleep Disorders Unit, Iraklion, Greece.
   [Rizzo, Manfredi] Univ Palermo, Biomed Dept Internal Med & Med Specialties, Sch Med, Palermo, Italy.
   [Rizzo, Manfredi] Univ South Carolina, Div Endocrinol Diabet & Metab, Sch Med Columbia, Columbia, SC 29208 USA.
C3 Democritus University of Thrace; Democritus University of Thrace;
   Democritus University of Thrace; Democritus University of Thrace;
   Aristotle University of Thessaloniki; George Papanikolaou General
   Hospital of Thessaloniki; University of Crete; University of Palermo;
   University of South Carolina System; University of South Carolina
   Columbia
RP Voulgaris, A (corresponding author), Democritus Univ Thrace, Dept Pneumonol, Med Sch, Alexandroupolis 68100, Greece.
EM thanasisvoul@hotmail.com
RI RIZZO, MANFREDI/GZL-0551-2022; Voulgaris, Athanasios/IUM-9495-2023;
   Nena, Evangelia/AAD-9385-2019; Steiropoulos, Paschalis/AAH-6905-2021
OI Nena, Evangelia/0000-0003-0381-4715
CR Al Lawati NM, 2009, PROG CARDIOVASC DIS, V51, P285, DOI 10.1016/j.pcad.2008.08.001
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   [Anonymous], EXP CLIN ENDOCRINOL
   Assoumou HGN, 2012, SLEEP BREATH, V16, P895, DOI 10.1007/s11325-011-0593-y
   Barnes PJ, 2009, EUR RESPIR J, V33, P1165, DOI 10.1183/09031936.00128008
   Berry RB, 2012, J CLIN SLEEP MED, V8, P597, DOI 10.5664/jcsm.2172
   Bonsignore MR, 2019, MULTIDISCIP RESP MED, V14, DOI 10.1186/s40248-019-0172-9
   Bonsignore MR, 2015, Obstructive sleep apnoea, P221, DOI [10.1183/2312508X.10006014, DOI 10.1183/2312508X.10006014]
   Bouloukaki I, 2011, SLEEP BREATH, V15, P657, DOI 10.1007/s11325-010-0416-6
   Castaneda A, 2018, WORLD J DIABETES, V9, DOI 10.4239/wjd.v9.i4.66
   Edwards BA, 2017, RESPIROLOGY, V22, P33, DOI 10.1111/resp.12913
   Eisele HJ, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/608438
   Funakoshi Y, 2010, INTERNAL MED, V49, P2093, DOI 10.2169/internalmedicine.49.3882
   Gasa M, 2011, EUR RESPIR J, V38, P1089, DOI 10.1183/09031936.00198810
   Hildrum B, 2007, BMC PUBLIC HEALTH, V7, DOI 10.1186/1471-2458-7-220
   Hoyos CM, 2013, THORAX, V68, P588, DOI 10.1136/thoraxjnl-2012-203074
   Kano M, 2007, CHEST, V131, P1387, DOI 10.1378/chest.06-1807
   Lacedonia D, 2013, RESP MED, V107, P310, DOI 10.1016/j.rmed.2012.10.012
   Lacedonia D, 2018, CLIN RESPIR J, V12, P1905, DOI 10.1111/crj.12754
   Lipovec NC, 2016, COPD, V13, P399, DOI 10.3109/15412555.2016.1140732
   Mathers CD, 2006, PLOS MED, V3, DOI 10.1371/journal.pmed.0030442
   McNicholas WT, 2009, AM J RESP CRIT CARE, V180, P692, DOI 10.1164/rccm.200903-0347PP
   Melo LC, 2014, EINSTEIN-SAO PAULO, V12, P120, DOI 10.1590/S1679-45082014RW2691
   Mirza S, 2018, MAYO CLIN PROC, V93, P1488, DOI 10.1016/j.mayocp.2018.05.026
   Naik Dukhabandhu, 2014, Indian J Endocrinol Metab, V18, P608, DOI 10.4103/2230-8210.139212
   Owens RL, 2010, RESP CARE, V55, P1333
   Papanas N, 2010, VASC HEALTH RISK MAN, V6, P281
   Passali D, 2015, ACTA OTORHINOLARYNGO, V35, P420, DOI 10.14639/0392-100X-895
   Peled N, 2007, RESP MED, V101, P1696, DOI 10.1016/j.rmed.2007.02.025
   Quaderi SA, 2018, GLOB HEALTH EPIDEM G, V3, DOI 10.1017/gheg.2018.1
   Rabe KF, 2007, AM J RESP CRIT CARE, V176, P532, DOI 10.1164/rccm.200703-456SO
   Salord N, 2009, OBES SURG, V19, P74, DOI 10.1007/s11695-008-9670-0
   Tsara Venetia, 2004, Sleep Breath, V8, P91, DOI 10.1007/s11325-004-0091-6
   Tune JD, 2017, TRANSL RES, V183, P57, DOI 10.1016/j.trsl.2017.01.001
   Van Eeden SF, 2013, CAN RESPIR J, V20, P27, DOI 10.1155/2013/509130
   Voulgaris A, 2019, CLIN RESPIR J, V13, P708, DOI 10.1111/crj.13078
   World Med Assoc, 2013, JAMA-J AM MED ASSOC, V310, P2191, DOI 10.1001/jama.2013.281053
   Xu SY, 2015, BMC PULM MED, V15, DOI 10.1186/s12890-015-0102-3
   Young T, 2002, ARCH INTERN MED, V162, P893, DOI 10.1001/archinte.162.8.893
   Zito A, 2011, EUR RESPIR J, V37, P717, DOI 10.1183/09031936.00120510
NR 40
TC 7
Z9 7
U1 0
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD AUG 1
PY 2020
VL 18
IS 6
BP 296
EP 301
DI 10.1089/met.2019.0126
EA MAY 2020
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA MR7KE
UT WOS:000533203300001
PM 32379990
DA 2025-06-11
ER

PT J
AU Matsumori, R
   Miyazaki, T
   Shimada, K
   Kume, A
   Kitamura, Y
   Oshida, K
   Yanagisawa, N
   Kiyanagi, T
   Hiki, M
   Fukao, K
   Hirose, K
   Ohsaka, H
   Mokuno, H
   Daida, H
AF Matsumori, Rie
   Miyazaki, Tetsuro
   Shimada, Kazunori
   Kume, Atsumi
   Kitamura, Yohei
   Oshida, Kyoichi
   Yanagisawa, Naotake
   Kiyanagi, Takashi
   Hiki, Makoto
   Fukao, Kosuke
   Hirose, Kuniaki
   Ohsaka, Hiromichi
   Mokuno, Hiroshi
   Daida, Hiroyuki
TI High levels of very long-chain saturated fatty acid in erythrocytes
   correlates with atherogenic lipoprotein profiles in subjects with
   metabolic syndrome
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE Atherogenic lipoproteins; Inflammation; Metabolic syndrome; Peroxisomal
   dysfunction; Saturated very long-chain fatty acid
ID RED-BLOOD-CELLS; OXIDATIVE STRESS; CHOLESTEROL; SERUM; LDL; MORTALITY;
   CYTOKINES; MEMBRANES; PLASMA; RISK
AB Aim: Very long chain saturated fatty acid (VLCFA) levels in erythrocytes are associated with metabolic syndrome (MS). However, the relationship between levels of the VLCFA ligonoceric acid (C24:0) in erythrocytes and the atherogenic lipoprotein profiles and inflammatory state in MS remain unclear.
   Methods: Based on the International Diabetes Federation (IDF) definition of MS, 195 apparently healthy males were assigned to either an MS group (n = 38) or a non-MS group (n = 157). Fatty acid composition of erythrocytes was determined by gas liquid chromatography.
   Results: Erythrocytes from the MS group had a significantly higher level of C24: 0 than cells from the non-MS group (4.06 +/- 0.48% versus 3.88 +/- 0.34%; p = 0.03). C24: 0 levels were significantly correlated with several components of MS. The C24: 0 levels showed a significant negative correlation with LDL and HDL particle size. Multivariate linear regression analysis showed that C24: 0 levels were independently correlated with LDL particle size after adjusting for age and each MS criterion. C24: 0 levels were also positively correlated with log-transformed high-sensitivity CRP levels (p = 0.04).
   Conclusion: C24: 0 levels in erythrocytes are associated with specific atherogenic lipoprotein profiles and inflammation status in subjects with MS. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
C1 [Matsumori, Rie; Miyazaki, Tetsuro; Shimada, Kazunori; Kume, Atsumi; Kiyanagi, Takashi; Hiki, Makoto; Fukao, Kosuke; Hirose, Kuniaki; Ohsaka, Hiromichi; Mokuno, Hiroshi; Daida, Hiroyuki] Juntendo Univ, Dept Cardiovasc Med, Sch Med, Tokyo 1138421, Japan.
   [Kitamura, Yohei; Yanagisawa, Naotake] Morinaga Milk Ind Co Ltd, Nutr Res Dept, Nutr Sci Inst, Zama, Kanagawa, Japan.
   [Oshida, Kyoichi] Kemin Japan KK, Tokyo, Japan.
C3 Juntendo University; Morinaga Milk Industry Company, Ltd
RP Miyazaki, T (corresponding author), Juntendo Univ, Dept Cardiovasc Med, Sch Med, 2-1-1 Hongo Bunkyo Ku, Tokyo 1138421, Japan.
EM tetsuro@juntendo.ac.jp
RI ohsaka, hiromichi/AAQ-4712-2020
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Antoku Y, 2000, ATHEROSCLEROSIS, V153, P169, DOI 10.1016/S0021-9150(00)00393-2
   Assies J, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010635
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Dhaunsi GS, 2005, CELL BIOCHEM FUNCT, V23, P65, DOI 10.1002/cbf.1173
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Grundy SM, 2004, J CLIN ENDOCR METAB, V89, P2595, DOI 10.1210/jc.2004-0372
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   HO JK, 1995, J CLIN INVEST, V96, P1455, DOI 10.1172/JCI118182
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jakobsson A, 2006, PROG LIPID RES, V45, P237, DOI 10.1016/j.plipres.2006.01.004
   Kou JQ, 2011, ACTA NEUROPATHOL, V122, P271, DOI 10.1007/s00401-011-0836-9
   Kratz M, 2002, J NUTR, V132, P715, DOI 10.1093/jn/132.4.715
   Kume A, 2008, DIABETES RES CLIN PR, V80, P259, DOI 10.1016/j.diabres.2007.12.014
   Laaksonen DE, 2002, DIABETIC MED, V19, P456, DOI 10.1046/j.1464-5491.2002.00707.x
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mauger JF, 2003, AM J CLIN NUTR, V78, P370, DOI 10.1093/ajcn/78.3.370
   Miyazaki T, 2005, ATHEROSCLEROSIS, V179, P139, DOI 10.1016/j.atherosclerosis.2004.09.013
   Miyazaki T, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-122
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Ofman R, 2010, EMBO MOL MED, V2, P90, DOI 10.1002/emmm.201000061
   Périchon R, 1998, CELL MOL LIFE SCI, V54, P641, DOI 10.1007/s000180050192
   Poirier Y, 2006, BBA-MOL CELL RES, V1763, P1413, DOI 10.1016/j.bbamcr.2006.08.034
   Rice BH, 2010, J NUTR, V140, P2173, DOI 10.3945/jn.110.127258
   Singh J, 2011, J LIPID RES, V52, P2056, DOI 10.1194/jlr.M017491
   Tsuda K, 2011, J OBES, V2011, DOI 10.1155/2011/548140
   Tsuda K, 2010, INT HEART J, V51, P121, DOI 10.1536/ihj.51.121
   Usui S, 2002, J LIPID RES, V43, P805
   Van Veldhoven PP, 2010, J LIPID RES, V51, P2863, DOI 10.1194/jlr.R005959
   Vessby B, 2003, CURR OPIN LIPIDOL, V14, P15, DOI 10.1097/00041433-200302000-00004
   WHITCOMB RW, 1988, J CLIN INVEST, V81, P185, DOI 10.1172/JCI113292
   Yanagisawa N, 2010, J ATHEROSCLER THROMB, V17, P285, DOI 10.5551/jat.2618
   Yanagisawa N, 2008, LIPIDS HEALTH DIS, V7, DOI 10.1186/1476-511X-7-48
   Zadravec D, 2010, FASEB J, V24, P4366, DOI 10.1096/fj.09-152298
NR 35
TC 25
Z9 25
U1 3
U2 20
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD JAN
PY 2013
VL 99
IS 1
BP 12
EP 18
DI 10.1016/j.diabres.2012.10.025
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 055DS
UT WOS:000312396000008
PM 23146370
DA 2025-06-11
ER

PT J
AU Cha, JC
   Ivanov, V
   Roomi, MW
   Kalinovsky, T
   Niedzwiecki, A
   Rath, M
AF Cha, J. C.
   Ivanov, V.
   Roomi, M. W.
   Kalinovsky, T.
   Niedzwiecki, A.
   Rath, M.
TI Nutritional improvement of metabolic syndrome parameters in immature
   fructose-fed wild-type mice
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE diabetes nutrient mix; metformin; C57/BL6 J wild-type mice; fructose
   diet; metabolic syndrome parameters; fructosamine; lipid profile;
   systolic blood pressure
ID DIABETES-MELLITUS; INSULIN SENSITIVITY; OXIDATIVE STRESS; RATS; ACID;
   GLYCATION; COLLAGEN; GLUCOSE; DIET; MECHANISM
AB The incidence of type 2 diabetes mellitus is on the increase worldwide, with both environmental and genetic factors implicated in its development. Diabetes is often preceded by metabolic syndrome (MS) and may develop in normal adults ingesting a high fructose diet. The effect of high fructose intake on the development of MS in children and adolescents is less clear. Our objective was to study the effects of a nutrient mixture and metformin (MET), a widely used oral diabetic medication, in modulating the physiological and biochemical parameters of a high fructose diet in immature mice. C57BL/6J wild-type mice aged 7 weeks were administered 12% fructose in their water and MET in distilled water or a diabetic nutrient mix (DNM) over 7 weeks. DNM-fed mice showed a decrease in systolic blood pressure, total cholesterol and fructosamine compared to the fructose-fed only group (p<0.05). A discordant result was observed in the MET group, with a decrease in blood pressure but increases in total cholesterol and fructosamine (p<0.05). Serum glucose did not change significantly among the groups. Thus, symptoms of fructose-induced MS in young mice could be countered nutritionally. Additionally, MET may improve certain biochemical markers while worsening others.
C1 [Cha, J. C.; Ivanov, V.; Roomi, M. W.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M.] Dr Rath Res Inst, Santa Clara, CA 95050 USA.
RP Niedzwiecki, A (corresponding author), Dr Rath Res Inst, 1260 Memorex Dr, Santa Clara, CA 95050 USA.
EM author@drrath.com
OI Cha, John/0000-0003-2710-7476
FU Dr Rath Health Foundation (Plantation, FL, USA)
FX This study was funded by the Dr Rath Health Foundation (Plantation, FL,
   USA), a non-profit organization.
CR ARMBRUSTER D, 1987, CLIN CHEM, V33, P2135
   Arora S, 2006, ANN VASC SURG, V20, P653, DOI 10.1007/s10016-006-9055-6
   BAKER JR, 1983, BMJ-BRIT MED J, V287, P863, DOI 10.1136/bmj.287.6396.863
   Cavender MA, 2010, AM J CARDIOVASC DRUG, V10, P209, DOI 10.2165/11539500-000000000-00000
   Chen YM, 2009, P NATL ACAD SCI USA, V106, P3907, DOI 10.1073/pnas.0807991106
   CUNNINGHAM JJ, 1994, J AM COLL NUTR, V13, P344, DOI 10.1080/07315724.1994.10718420
   Degenhardt TP, 1999, DIABETES RES CLIN PR, V43, P81, DOI 10.1016/S0168-8227(98)00121-1
   Farah V, 2006, AUTON NEUROSCI-BASIC, V130, P41, DOI 10.1016/j.autneu.2006.05.006
   González-Ortiz M, 2011, EUR J NUTR, V50, P145, DOI 10.1007/s00394-010-0123-x
   Hofmann SM, 2002, DIABETES, V51, P2082, DOI 10.2337/diabetes.51.7.2082
   HUJBERTS MS, 1994, DIABETOLOGIA, V37, P10
   Lankin VZ, 2007, BIOCHEMISTRY-MOSCOW+, V72, P1081, DOI 10.1134/S0006297907100069
   Liu J, 2007, BIOL PHARM BULL, V30, P2075, DOI 10.1248/bpb.30.2075
   Meigs James B, 2010, Diabetes Care, V33, P1865, DOI 10.2337/dc10-0641
   MONNIER VM, 1992, DIABETES, V41, P36, DOI 10.2337/diab.41.2.S36
   Nyengaard JR, 1997, DIABETES, V46, P94, DOI 10.2337/diabetes.46.1.94
   Oron-Herman M, 2008, AM J HYPERTENS, V21, P1018, DOI 10.1038/ajh.2008.218
   Pedchenko VK, 2005, DIABETES, V54, P2952, DOI 10.2337/diabetes.54.10.2952
   Peng XF, 2008, J AGR FOOD CHEM, V56, P1907, DOI 10.1021/jf073065v
   Perez-Pozo SE, 2010, INT J OBESITY, V34, P454, DOI 10.1038/ijo.2009.259
   Piatti P, 2001, DIABETES CARE, V24, P875, DOI 10.2337/diacare.24.5.875
   Rabbani N, 2008, BIOCHEM SOC T, V36, P1045, DOI 10.1042/BST0361045
   Sim MK, 2009, BIOSCI BIOTECH BIOCH, V73, P2583, DOI 10.1271/bbb.90328
   Siscovick DS, 2010, REV ENDOCR METAB DIS, V11, P53, DOI 10.1007/s11154-010-9133-5
   Suwannaphet W, 2010, FOOD CHEM TOXICOL, V48, P1853, DOI 10.1016/j.fct.2010.04.021
   Tanaka M, 2006, BIOL PHARM BULL, V29, P1418, DOI 10.1248/bpb.29.1418
   THUNG P. J., 1962, ACTA PHYSIOL ET PHARMACOL NEERLAND, V10, P248
   Urios P, 2007, EUR J NUTR, V46, P139, DOI 10.1007/s00394-007-0644-0
   van Dieren S, 2010, EUR J CARDIOV PREV R, V17, pS3, DOI 10.1097/01.hjr.0000368191.86614.5a
   Wang XK, 2010, J PHARMACOL EXP THER, V334, P820, DOI 10.1124/jpet.110.167635
   Yi XW, 2006, DIABETES, V55, P2238, DOI 10.2337/db06-0251
   Zanoni JN, 2007, BRAZ ARCH BIOL TECHN, V50, P31, DOI 10.1590/S1516-89132007000100004
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI13505
   Zygmunt K, 2010, BIOCHEM BIOPH RES CO, V398, P178, DOI 10.1016/j.bbrc.2010.06.048
NR 34
TC 1
Z9 2
U1 0
U2 4
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
J9 MOL MED REP
JI Mol. Med. Rep.
PD NOV-DEC
PY 2011
VL 4
IS 6
BP 1053
EP 1059
DI 10.3892/mmr.2011.562
PG 7
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA 826XR
UT WOS:000295389400003
PM 21874237
OA Bronze
DA 2025-06-11
ER

PT J
AU Maksyutynska, K
   Stogios, N
   Prasad, F
   Gill, J
   Hamza, Z
   De, R
   Smith, E
   Horta, A
   Goldstein, BI
   Korczak, D
   Graff-Guerrero, A
   Hahn, MK
   Agarwal, SM
AF Maksyutynska, Kateryna
   Stogios, Nicolette
   Prasad, Femin
   Gill, Jashan
   Hamza, Zaineb
   De, Riddhita
   Smith, Emily
   Horta, Angelina
   Goldstein, Benjamin I.
   Korczak, Daphne
   Graff-Guerrero, Ariel
   Hahn, Margaret K.
   Agarwal, Sri Mahavir
TI Neurocognitive correlates of metabolic dysregulation in individuals with
   mood disorders: a systematic review and meta-analysis
SO PSYCHOLOGICAL MEDICINE
LA English
DT Review
DE attention; bipolar disorder; cognition; diabetes; executive function;
   insulin resistance; major depressive disorder; memory; metabolic
   syndrome; mood disorders; obesity; processing speed
ID MAJOR DEPRESSIVE DISORDER; LATE-LIFE DEPRESSION; BIPOLAR I DISORDER;
   BODY-MASS INDEX; COGNITIVE IMPAIRMENT; INSULIN-RESISTANCE; EXECUTIVE
   FUNCTION; DIABETES-MELLITUS; OLDER-ADULTS; ASSOCIATION
AB Individuals with mood disorders are predisposed to metabolic dysfunction, while those with metabolic dysregulation such as diabetes and obesity experience more severe depressive symptoms. Both metabolic dysfunction and mood disorders are independently associated with cognitive deficits. Therefore, given their close association, this study aimed to explore the association between metabolic dysfunction in individuals with mood disorders in relation to cognitive outcomes. A comprehensive search comprised of these three domains was carried out; a random-effects meta-analysis pooling mean cognitive outcomes was conducted (PROSPERO ID: CRD42022295765). Sixty-three studies were included in this review; 26 were synthesized in a quantitative meta-analysis. Comorbid metabolic dysregulation was associated with significantly lower global cognition among individuals with mood disorders. These trends were significant within each mood disorder subgroup, including major depressive disorder, bipolar disorder, and self-report depression/depressive symptoms. Type 2 diabetes was associated with the lowest cognitive performance in individuals with mood disorders, followed by peripheral insulin resistance, body mass index 25 kg/m(2), and metabolic syndrome. Significant reduction in scores was also observed among individual cognitive domains (in descending order) of working memory, attention, executive function, processing speed, verbal memory, and visual memory. These findings demonstrate the detrimental effects of comorbid metabolic dysfunction in individuals with mood disorders. Further research is required to understand the underlying mechanisms connecting mood disorders, metabolism, and cognition.
C1 [Maksyutynska, Kateryna; Stogios, Nicolette; Prasad, Femin; Gill, Jashan; Hamza, Zaineb; De, Riddhita; Smith, Emily; Horta, Angelina; Goldstein, Benjamin I.; Korczak, Daphne; Graff-Guerrero, Ariel; Hahn, Margaret K.; Agarwal, Sri Mahavir] Univ Toronto, Inst Med Sci, Toronto, ON, Canada.
   [Maksyutynska, Kateryna; Stogios, Nicolette; Prasad, Femin; De, Riddhita; Smith, Emily; Hahn, Margaret K.; Agarwal, Sri Mahavir] Ctr Addict & Mental Hlth, Schizophrenia Div, Toronto, ON, Canada.
   [Gill, Jashan] McMaster Univ, Fac Sci, Hamilton, ON, Canada.
   [Hamza, Zaineb; Horta, Angelina] McMaster Univ, Fac Hlth Sci, Hamilton, ON, Canada.
   [Goldstein, Benjamin I.; Korczak, Daphne; Graff-Guerrero, Ariel; Hahn, Margaret K.; Agarwal, Sri Mahavir] Univ Toronto, Dept Psychiat, Fac Med, Toronto, ON, Canada.
   [Goldstein, Benjamin I.] Ctr Addict & Mental Hlth, Ctr Youth Bipolar Disorder, Toronto, ON, Canada.
   [Goldstein, Benjamin I.] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada.
   [Korczak, Daphne] Hosp Sick Children, Dept Psychiat, Toronto, ON, Canada.
   [Graff-Guerrero, Ariel] Res Imaging Ctr, Ctr Addict & Mental Hlth, Toronto, ON, Canada.
C3 University of Toronto; University of Toronto; Centre for Addiction &
   Mental Health - Canada; McMaster University; McMaster University;
   University of Toronto; University of Toronto; Centre for Addiction &
   Mental Health - Canada; University of Toronto; University of Toronto;
   Hospital for Sick Children (SickKids); University of Toronto; Centre for
   Addiction & Mental Health - Canada
RP Agarwal, SM (corresponding author), Univ Toronto, Inst Med Sci, Toronto, ON, Canada.; Agarwal, SM (corresponding author), Ctr Addict & Mental Hlth, Schizophrenia Div, Toronto, ON, Canada.; Agarwal, SM (corresponding author), Univ Toronto, Dept Psychiat, Fac Med, Toronto, ON, Canada.
EM Mahavir.Agarwal@camh.ca
RI Agarwal, Mahavir/ITV-3244-2023; Goldstein, Benjamin/ADR-2374-2022
OI De, Riddhita/0000-0002-8953-4716; Stogios, Nicolette/0000-0001-9136-4923
FU Department of Psychiatry, University of Toronto; CAMH Discovery Fund
FX The authors would like to thank Dr Van Rheenen et al., Dr Hubenak et
   al., and Dr Geraets et al. for providing additional information to
   synthesize in this review. S. M. A. is supported by in part by an
   Academic Scholars Award from the Department of Psychiatry, University of
   Toronto and the CAMH Discovery Fund. B. I. G. acknowledges his position
   as RBC Investments Chair in Children's Mental Health and Developmental
   Psychopathology at CAMH, a joint Hospital-University Chair between the
   University of Toronto, CAMH, and the CAMH Foundation.
CR Bai YM, 2016, BMC PSYCHIATRY, V16, DOI 10.1186/s12888-016-1143-8
   Beunders AJM, 2021, ACTA PSYCHIAT SCAND, V144, P392, DOI 10.1111/acps.13342
   Bond DJ, 2017, ACTA PSYCHIAT SCAND, V135, P239, DOI 10.1111/acps.12674
   Bora E, 2017, PSYCHOL MED, V47, P1030, DOI 10.1017/S0033291716003366
   Bora E, 2019, PSYCHOL MED, V49, P738, DOI 10.1017/S0033291718003008
   Borhaninejad V, 2022, ACTA FAC MEDICAE NAI, V39, P85, DOI 10.5937/afmnai39-34820
   Burdick KE, 2010, ACTA PSYCHIAT SCAND, V122, P499, DOI 10.1111/j.1600-0447.2010.01590.x
   Cao F, 2023, FRONT AGING NEUROSCI, V15, DOI 10.3389/fnagi.2023.1081393
   Chang HH, 2022, CNS SPECTRUMS, V27, P598, DOI 10.1017/S1092852921000158
   Chang TT, 2015, PSYCHOGERIATRICS, V15, P109, DOI 10.1111/psyg.12080
   Chen MH, 2021, CNS SPECTRUMS, V26, P521, DOI 10.1017/S1092852920001534
   Chen ST, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0098630
   Choi DW, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-44158-7
   Chow YY, 2022, DIABETES RES CLIN PR, V185, DOI 10.1016/j.diabres.2022.109227
   Corréard N, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184313
   Cramer V, 2010, NORD J PSYCHIAT, V64, P58, DOI 10.3109/08039480903287565
   Cutler RL, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2017-016982
   Dalkner N, 2021, FRONT NEUROSCI-SWITZ, V15, DOI 10.3389/fnins.2021.717824
   Dalkner N, 2021, NEUROPSYCHOBIOLOGY, V80, P1, DOI 10.1159/000505784
   Demakakos P, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0175827
   Dennis M, 2009, J INT NEUROPSYCH SOC, V15, P331, DOI 10.1017/S1355617709090481
   Depp CA, 2014, BIPOLAR DISORD, V16, P422, DOI 10.1111/bdi.12200
   Downer B, 2016, J AM GERIATR SOC, V64, P109, DOI 10.1111/jgs.13883
   Ferri F, 2021, AGING MENT HEALTH, V25, P2003, DOI 10.1080/13607863.2020.1792412
   Fourrier C, 2020, BRAIN BEHAV IMMUN, V88, P242, DOI 10.1016/j.bbi.2020.06.007
   Frey BN, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.20213
   Geraets AFJ, 2022, J AFFECT DISORDERS, V313, P110, DOI 10.1016/j.jad.2022.06.045
   Borda MG, 2019, EUR GERIATR MED, V10, P413, DOI 10.1007/s41999-019-00185-1
   Guan LY, 2021, J PSYCHIATR RES, V143, P580, DOI 10.1016/j.jpsychires.2020.11.022
   Guo M, 2014, CLIN EXP PHARMACOL P, V41, P650, DOI 10.1111/1440-1681.12265
   Hamer JA, 2019, EXP NEUROL, V315, P1, DOI 10.1016/j.expneurol.2019.01.016
   Hidese S, 2018, J AFFECT DISORDERS, V225, P188, DOI 10.1016/j.jad.2017.08.028
   Hubenak J, 2015, NEUROENDOCRINOL LETT, V36, P294
   Hui L, 2019, INT J BIPOLAR DISORD, V7, DOI 10.1186/s40345-019-0159-7
   Janocha A, 2010, NEUROENDOCRINOL LETT, V31, P399
   Jia QF, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-77782-9
   Johar H, 2023, PREV MED, V167, DOI 10.1016/j.ypmed.2022.107390
   Kadriu B, 2024, BIPOLAR DISORD, V26, P160, DOI 10.1111/bdi.13370
   Karlsson IK, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-86667-4
   Kloiber S, 2007, BIOL PSYCHIAT, V62, P321, DOI 10.1016/j.biopsych.2006.10.001
   Kontari P, 2019, INT J GERIATR PSYCH, V34, P289, DOI 10.1002/gps.5019
   Kopchak Oksana, 2017, Wiad Lek, V70, P737
   Korczak DJ, 2011, DIABETOLOGIA, V54, P2483, DOI 10.1007/s00125-011-2240-3
   Kraus C, 2023, J AFFECT DISORDERS, V335, P349, DOI 10.1016/j.jad.2023.05.042
   La Montagna M, 2017, EUR PSYCHIAT, V41, pS207, DOI 10.1016/j.eurpsy.2017.01.2167
   Lackner N, 2016, WORLD J BIOL PSYCHIA, V17, P535, DOI 10.3109/15622975.2015.1046917
   Lan XF, 2022, J AFFECT DISORDERS, V313, P118, DOI 10.1016/j.jad.2022.06.073
   Li CT, 2015, PSYCHONEUROENDOCRINO, V55, P72, DOI 10.1016/j.psyneuen.2015.02.003
   Liebing S, 2023, J AFFECT DISORDERS, V323, P251, DOI 10.1016/j.jad.2022.11.067
   Lin QM, 2022, CHILD ADOL PSYCH MEN, V16, DOI 10.1186/s13034-022-00468-9
   Liu ZR, 2023, GERONTOLOGY, V69, P899, DOI 10.1159/000530200
   Mann EM, 2022, BMC PUBLIC HEALTH, V22, DOI 10.1186/s12889-022-12905-7
   Mansur RB, 2020, BIPOLAR DISORD, V22, P79, DOI 10.1111/bdi.12826
   Mansur RB, 2017, J AFFECT DISORDERS, V207, P114, DOI 10.1016/j.jad.2016.09.056
   Mansur RB, 2015, NEUROSCI BIOBEHAV R, V52, P89, DOI 10.1016/j.neubiorev.2014.12.017
   Marijnissen RM, 2017, PSYCHOL MED, V47, P1041, DOI 10.1017/S0033291716003196
   Martinez-Aran A, 2009, J CLIN PSYCHIAT, V70, P1017, DOI 10.4088/JCP.08m04408
   Marvel CL, 2004, PSYCHIAT CLIN N AM, V27, P19, DOI 10.1016/S0193-953X(03)00106-0
   McIntyre RS, 2015, J AFFECT DISORDERS, V172, P259, DOI 10.1016/j.jad.2014.09.026
   Mehra A, 2022, INDIAN J PSYCHIAT, V64, pS528, DOI 10.4103/0019-5545.341507
   Modesti PA, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0147601
   Mohammed SH, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-028238
   Mora E, 2017, J CLIN PSYCHIAT, V78, pE924, DOI 10.4088/JCP.16m10968
   Naiberg MR, 2016, ACTA PSYCHIAT SCAND, V134, P241, DOI 10.1111/acps.12603
   Naiberg MR, 2016, J PSYCHIATR RES, V83, P230, DOI 10.1016/j.jpsychires.2016.08.019
   Ng TP, 2009, J AM GERIATR SOC, V57, P1058, DOI 10.1111/j.1532-5415.2009.02262.x
   Page Matthew J, 2021, BMJ, V372, pn71, DOI [10.1016/j.ijsu.2021.105906, 10.1136/bmj.n71]
   Péterfalvi A, 2019, FRONT PSYCHOL, V10, DOI 10.3389/fpsyg.2019.01798
   Pillinger T, 2020, LANCET PSYCHIAT, V7, P64, DOI 10.1016/S2215-0366(19)30416-X
   Qiu WX, 2021, FRONT NEUROSCI-SWITZ, V15, DOI 10.3389/fnins.2021.728810
   Qiu Y, 2022, J AFFECT DISORDERS, V297, P477, DOI 10.1016/j.jad.2021.10.100
   Quintana DS, 2023, ADV METH PRACT PSYCH, V6, DOI 10.1177/25152459221147260
   Reininghaus B, 2022, NUTRIENTS, V14, DOI 10.3390/nu14061176
   Restivo MR, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0176898
   Ringin E., 2023, Relative associations of behavioural and physiological risks for cardiometabolic disease with cognition in bipolar disorder: Findings from the UK Biobank, DOI [10.31234/osf.io/gpnmd, DOI 10.31234/OSF.IO/GPNMD]
   Ringin E, 2023, NEUROPSYCHOPHARMACOL, V48, P362, DOI 10.1038/s41386-022-01471-6
   Roy T, 2012, J AFFECT DISORDERS, V142, pS8, DOI 10.1016/S0165-0327(12)70004-6
   Salvi V, 2020, J AFFECT DISORDERS, V266, P610, DOI 10.1016/j.jad.2020.01.145
   Scuteri A, 2011, ARCH GERONTOL GERIAT, V52, P253, DOI 10.1016/j.archger.2010.04.002
   Shao TN, 2017, COMPR PSYCHIAT, V75, P103, DOI 10.1016/j.comppsych.2017.03.007
   Siegel-Ramsay J. E., 2022, Journal of Affective Disorders Reports, V10, DOI [10.1016/j.jadr.2022.100442, DOI 10.1016/J.JADR.2022.100442]
   Silveira LE, 2014, CAN J PSYCHIAT, V59, P639, DOI 10.1177/070674371405901205
   Singh MK, 2019, HORM BEHAV, V108, P73, DOI 10.1016/j.yhbeh.2018.03.009
   Smith PJ, 2018, AM J GERIAT PSYCHIAT, V26, P1061, DOI 10.1016/j.jagp.2018.06.011
   Tsai SY, 2007, BIPOLAR DISORD, V9, P868, DOI 10.1111/j.1399-5618.2007.00498.x
   Van Rheenen TE, 2021, J AFFECT DISORDERS, V278, P556, DOI 10.1016/j.jad.2020.09.104
   Wang AY, 2023, JPAD-J PREV ALZHEIM, V10, P83, DOI 10.14283/jpad.2022.81
   Wei JK, 2019, J PSYCHIATR RES, V111, P30, DOI 10.1016/j.jpsychires.2019.01.012
   Wroolie TE, 2015, J PSYCHIATR RES, V60, P65, DOI 10.1016/j.jpsychires.2014.10.001
   Yim CY, 2012, EUR PSYCHIAT, V27, P223, DOI 10.1016/j.eurpsy.2011.02.004
   Zhang XY, 2021, J AFFECT DISORDERS, V290, P387, DOI 10.1016/j.jad.2021.04.092
   Zhuo CJ, 2022, FRONT PSYCHIATRY, V13, DOI 10.3389/fpsyt.2022.880031
NR 92
TC 7
Z9 7
U1 6
U2 21
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD MAY
PY 2024
VL 54
IS 7
BP 1245
EP 1271
DI 10.1017/S0033291724000345
PG 27
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 2XY2K
UT WOS:001493962600001
PM 38450447
OA hybrid
DA 2025-06-11
ER

PT J
AU Gallagher, D
   Kiss, A
   Lanctot, K
   Herrmann, N
AF Gallagher, Damien
   Kiss, Alex
   Lanctot, Krista
   Herrmann, Nathan
TI Depressive symptoms and cognitive decline: A longitudinal analysis of
   potentially modifiable risk factors in community dwelling older adults
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Older age; Inflammation; Cognition; Physical activity;
   Vascular risk factors
ID ALZHEIMERS-DISEASE; NEUROTROPHIC FACTOR; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; DEMENTIA; INFLAMMATION; METAANALYSIS; IMPAIRMENT;
   EXERCISE; INCREASE
AB Background: Depressive symptoms have been associated with increased risk of cognitive decline in later life. There are no interventions proven to reduce risk of cognitive decline in older adults with depression, and it is unclear how these effects are mediated. We aim to determine what mediates the relationship between depressive symptoms and cognitive decline in later life.
   Methods: Seven thousand six hundred and sixty six community dwelling older adults (age >= 50) from the English Longitudinal study of Ageing (ELSA) underwent clinical assessment. Inflammation was assessed with C Reactive Protein and depressive symptoms were assessed with the 8-item version of the Center for Epidemiologic Studies (CESD) scale.
   Results: Five thousand, five hundred and ninety (73.5%) had a follow-up cognitive assessment after a median of 47 months. Depressive symptoms were independently associated with cognitive decline (B=0.09, p < 0.001). Low physical activity, inflammation, metabolic syndrome and vascular risk factors were associated with elevated depressive symptoms. Low physical activity (z=2.16, p=0.03) and inflammation (z=2.3, p=0.02) mediated the relationship between depressive symptoms and cognitive decline while hypertension, diabetes and smoking also contributed.
   Limitations: This is an observational study with a limited duration of follow up. Not all variables related to cognitive decline were accounted for in this analysis.
   Conclusions: The relationship between depressive symptoms and cognitive decline in later life appears to be mediated by low physical activity, increased inflammation and vascular risk factors that may be amenable to modification. (C) 2015 Published by Elsevier B.V.
C1 [Gallagher, Damien; Herrmann, Nathan] Sunnybrook Hlth Sci Ctr, Div Geriatr Psychiat, Toronto, ON M4N 3M5, Canada.
   [Gallagher, Damien; Herrmann, Nathan] Univ Toronto, Toronto, ON M5S 1A1, Canada.
   [Kiss, Alex; Lanctot, Krista] Univ Toronto, Sunnybrook Res Inst, Toronto, ON M5S 1A1, Canada.
   [Kiss, Alex] Univ Toronto, Dept Hlth Policy Management & Evaluat, Toronto, ON M5S 1A1, Canada.
   [Lanctot, Krista] Univ Toronto, Dept Psychiat, Toronto, ON M5S 1A1, Canada.
   [Lanctot, Krista] Univ Toronto, Dept Pharmacol, Toronto, ON M5S 1A1, Canada.
   [Lanctot, Krista] Univ Toronto, Dept Toxicol, Toronto, ON M5S 1A1, Canada.
C3 University of Toronto; Sunnybrook Health Science Center; Sunnybrook
   Research Institute; University of Toronto; University of Toronto;
   Sunnybrook Health Science Center; Sunnybrook Research Institute;
   University of Toronto; University of Toronto; University of Toronto;
   University of Toronto
RP Gallagher, D (corresponding author), Sunnybrook Hlth Sci Ctr, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada.
EM Damien.gallagher@sunnybrook.ca
RI Lanctot, Krista/AAY-4820-2020
CR Alberti K.G. M. M., 2006, METABOLIC SYNDROME N
   Alexopoulos GS, 2005, BIOL PSYCHIAT, V58, P204, DOI 10.1016/j.biopsych.2005.04.024
   Allied Dunbar National Fitness Survey, 1992, MAIN FIND ACT HLTH R
   [Anonymous], 1982, SOCIOL METHODOL
   Barnes DE, 2011, LANCET NEUROL, V10, P819, DOI 10.1016/S1474-4422(11)70072-2
   BARON RM, 1986, J PERS SOC PSYCHOL, V51, P1173, DOI 10.1037/0022-3514.51.6.1173
   Becker E., 2006, Health Surv Engl, P34
   Beekman ATF, 1997, PSYCHOL MED, V27, P231, DOI 10.1017/S0033291796003510
   Bettcher BM, 2014, CLIN PHARMACOL THER, V96, P464, DOI 10.1038/clpt.2014.147
   Bhalla RK, 2006, AM J GERIAT PSYCHIAT, V14, P419, DOI 10.1097/01.JGP.0000203130.45421.69
   Brunoni AR, 2008, INT J NEUROPSYCHOPH, V11, P1169, DOI 10.1017/S1461145708009309
   Butters MA, 2004, ARCH GEN PSYCHIAT, V61, P587, DOI 10.1001/archpsyc.61.6.587
   Cheshire H., 2012, FINANCIAL CIRCUMSTAN
   CORNONIHUNTLEY J, 1993, AGING-CLIN EXP RES, V5, P27
   Crichton GE, 2012, J ALZHEIMERS DIS, V30, pS77, DOI 10.3233/JAD-2011-111022
   Diniz BS, 2014, J GERONTOL B-PSYCHOL, V69, P845, DOI 10.1093/geronb/gbu096
   Diniz BS, 2013, BRIT J PSYCHIAT, V202, P329, DOI 10.1192/bjp.bp.112.118307
   Dotson VM, 2010, NEUROLOGY, V75, P27, DOI 10.1212/WNL.0b013e3181e62124
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Dwivedi Y, 2013, AM J GERIAT PSYCHIAT, V21, P433, DOI 10.1016/j.jagp.2012.10.026
   Gallagher D, 2013, J AFFECT DISORDERS, V147, P192, DOI 10.1016/j.jad.2012.10.037
   Gorelick PB, 2010, ANN NY ACAD SCI, V1207, P155, DOI 10.1111/j.1749-6632.2010.05726.x
   Green KN, 2006, J NEUROSCI, V26, P9047, DOI 10.1523/JNEUROSCI.2797-06.2006
   Green RC, 2003, ARCH NEUROL-CHICAGO, V60, P753, DOI 10.1001/archneur.60.5.753
   Kessing LV, 2004, J NEUROL NEUROSUR PS, V75, P1662, DOI 10.1136/jnnp.2003.031773
   Larson EB, 2006, ANN INTERN MED, V144, P73, DOI 10.7326/0003-4819-144-2-200601170-00004
   Lautenschlager NT, 2008, JAMA-J AM MED ASSOC, V300, P1027, DOI 10.1001/jama.300.9.1027
   Lu PH, 2009, NEUROLOGY, V72, P2115, DOI 10.1212/WNL.0b013e3181aa52d3
   Lupien SJ, 1998, NAT NEUROSCI, V1, P69, DOI 10.1038/271
   Maes M, 2011, PROG NEURO-PSYCHOPH, V35, P676, DOI 10.1016/j.pnpbp.2010.05.004
   Moylan S, 2013, MOL PSYCHIATR, V18, P595, DOI 10.1038/mp.2012.33
   Ngandu T, 2015, LANCET, V385, P2255, DOI 10.1016/S0140-6736(15)60461-5
   Ownby RL, 2006, ARCH GEN PSYCHIAT, V63, P530, DOI 10.1001/archpsyc.63.5.530
   Pasco JA, 2010, BRIT J PSYCHIAT, V197, P372, DOI 10.1192/bjp.bp.109.076430
   Pedersen BK, 2006, ESSAYS BIOCHEM, V42, P105, DOI 10.1042/bse0420105
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Raison CL, 2011, CURR PSYCHIAT REP, V13, P467, DOI 10.1007/s11920-011-0232-0
   Richard E, 2012, J ALZHEIMERS DIS, V32, P733, DOI 10.3233/JAD-2012-120772
   Saczynski JS, 2010, NEUROLOGY, V75, P35, DOI 10.1212/WNL.0b013e3181e62138
   Semmler A, 2005, J CHEM NEUROANAT, V30, P144, DOI 10.1016/j.jchemneu.2005.07.003
   Solomon A, 2014, J INTERN MED, V275, P229, DOI 10.1111/joim.12178
   Taylor WD, 2013, MOL PSYCHIATR, V18, P963, DOI 10.1038/mp.2013.20
   Wallace, 2005, DOC COGN FUNCT MEAS
   Wallace RB., 2000, DOCUMENTATION AFFECT
   Yaffe K, 2001, ARCH INTERN MED, V161, P1703, DOI 10.1001/archinte.161.14.1703
   Yaffe K, 2004, JAMA-J AM MED ASSOC, V292, P2237, DOI 10.1001/jama.292.18.2237
   Yaffe K, 2014, LANCET NEUROL, V13, P1017, DOI 10.1016/S1474-4422(14)70172-3
   Yang J., 2014, INT J GERIATR PSYCHI
NR 48
TC 62
Z9 69
U1 3
U2 36
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JAN 15
PY 2016
VL 190
BP 235
EP 240
DI 10.1016/j.jad.2015.09.046
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA CY5QT
UT WOS:000366463000035
PM 26521086
DA 2025-06-11
ER

PT J
AU Di Franco, A
   Lanza, GA
   Di Monaco, A
   Sestito, A
   Lamendola, P
   Nerla, R
   Tarzia, P
   Virdis, D
   Vollono, C
   Valeriani, M
   Crea, F
AF Di Franco, Antonino
   Lanza, Gaetano A.
   Di Monaco, Antonio
   Sestito, Alfonso
   Lamendola, Priscilla
   Nerla, Roberto
   Tarzia, Pierpaolo
   Virdis, Daniela
   Vollono, Catello
   Valeriani, Massimiliano
   Crea, Filippo
TI Coronary Microvascular Function and Cortical Pain Processing in Patients
   With Silent Positive Exercise Testing and Normal Coronary Arteries
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID CARDIAC SYNDROME-X; ANGINA-PECTORIS; CHEST-PAIN; MYOCARDIAL-ISCHEMIA;
   HEART-DISEASE; DYSFUNCTION; ANGIOGRAMS; SCINTIGRAPHY; SENSITIVITY;
   MORTALITY
AB ST-segment depression during exercise stress testing in asymptomatic subjects showing normal coronary arteries is considered a "false-positive" result. Coronary microvascular dysfunction, however, might be a possible cause of ST-segment depression in these cases. We assessed the coronary blood flow response to adenosine and to cold pressor test in the left anterior descending artery, using transthoracic Doppler echocardiography in 14 asymptomatic subjects with exercise-induced ST-segment depression and normal coronary arteries (group 1), 14 patients with microvascular angina (group 2), and 14 healthy subjects (group 3). Flow-mediated dilation was assessed in the brachial artery. Central pain processing was assessed using cortical laser evoked potentials during chest and right hand stimulation with 3 sequences of painful stimuli. The coronary blood flow response to adenosine was 1.8 +/- 0.4, 1.9 +/- 0.5, and 3.1 +/- 0.9 in groups 1, 2, and 3, respectively (p <0.001). The corresponding coronary blood flow responses to the cold pressor test were 1.74 +/- 0.4, 1.53 +/- 0.3, and 2.3 +/- 0.6 (p <0.001). The flow-mediated dilation was 5.5 +/- 2.3%, 4.6 +/- 2.4%, and 9.8 +/- 1.2% in the 3 groups, respectively (p <0.001). The laser evoked potential N2/P2 wave amplitude decreased throughout the 3 sequences of stimulation in groups 1 and 3 but not in group 2 (chest, -19 +/- 22%, +11 +/- 42% and -36 +/- 12%, p <0.001; right hand, -22 +/- 25%, +12 +/- 43% and -30 +/- 20%, p = 0.009; in groups 1, 2, and 3). In conclusion, exercise stress test-induced ST-segment depression in asymptomatic subjects with normal coronary arteries cannot be considered as a simple false-positive result, because it can be related to coronary microvascular dysfunction. The different symptomatic state compared to patients with microvascular angina can, at least in part, be explained by differences in cortical processing of neural pain stimuli. (C) 2012 Elsevier Inc. All rights reserved. (Am J Cardiol 2012;109:1705-1710)
C1 [Di Franco, Antonino; Lanza, Gaetano A.; Di Monaco, Antonio; Sestito, Alfonso; Lamendola, Priscilla; Nerla, Roberto; Tarzia, Pierpaolo; Crea, Filippo] Univ Cattolica Sacro Cuore, Inst Cardiol, Rome, Italy.
   [Virdis, Daniela; Vollono, Catello; Valeriani, Massimiliano] Univ Cattolica Sacro Cuore, Inst Neurol, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Lanza, GA (corresponding author), Univ Cattolica Sacro Cuore, Inst Cardiol, Rome, Italy.
EM g.a.lanza@rm.unicatt.it
RI Tarzia, Pierpaolo/AAC-1593-2019; Vollono, Catello/AAU-7072-2021; Nerla,
   Roberto/AAL-1534-2020; Crea, Filippo/AAC-9754-2022; Valeriani,
   Massimiliano/AAA-4459-2020; Lanza, Gaetano/AAC-2660-2019; Valeriani,
   Massimiliano/K-5736-2016; Di monaco, Antonio/AAR-8825-2021
OI Vollono, Catello/0000-0001-9371-8035; Valeriani,
   Massimiliano/0000-0001-6602-103X; Di monaco,
   Antonio/0000-0002-1297-2056; Nerla, Roberto/0000-0002-9065-3261
CR Arendt-Nielsen L, 2000, Prog Brain Res, V129, P343
   Camici PG, 2007, NEW ENGL J MED, V356, P830, DOI 10.1056/NEJMra061889
   CANNON RO, 1990, J AM COLL CARDIOL, V16, P1359, DOI 10.1016/0735-1097(90)90377-2
   Chauhan A, 1997, EUR HEART J, V18, P60
   EGASHIRA K, 1993, NEW ENGL J MED, V328, P1659, DOI 10.1056/NEJM199306103282302
   Gemignani V, 2007, IEEE T MED IMAGING, V26, P393, DOI 10.1109/TMI.2006.891477
   Gibbons LW, 2000, AM J CARDIOL, V86, P53, DOI 10.1016/S0002-9149(00)00827-4
   Glasser S P, 1986, Cardiol Clin, V4, P705
   HELLER GV, 1987, AM J CARDIOL, V59, P735, DOI 10.1016/0002-9149(87)91083-6
   Klem G H, 1999, Electroencephalogr Clin Neurophysiol Suppl, V52, P3
   Lamendola P, 2010, INT J CARDIOL, V140, P197, DOI 10.1016/j.ijcard.2008.11.026
   Lanza GA, 2004, AM J CARDIOL, V94, P40, DOI 10.1016/j.amjcard.2004.03.027
   Lanza GA, 1997, CIRCULATION, V96, P821
   Lanza GA, 2008, J AM COLL CARDIOL, V51, P466, DOI 10.1016/j.jacc.2007.08.060
   Lanza GA, 2010, CIRCULATION, V121, P2317, DOI 10.1161/CIRCULATIONAHA.109.900191
   Lyerly GW, 2008, CIRCULATION, V117, P2734, DOI 10.1161/CIRCULATIONAHA.107.729277
   MOTZ W, 1991, AM J CARDIOL, V68, P996, DOI 10.1016/0002-9149(91)90485-4
   Nerla R, 2011, HEART VESSELS, V26, P524, DOI 10.1007/s00380-010-0087-z
   NESTO RW, 1988, ANN INTERN MED, V108, P170, DOI 10.7326/0003-4819-108-2-170
   OPHERK D, 1981, CIRCULATION, V63, P817, DOI 10.1161/01.CIR.63.4.817
   Pasceri V, 1998, J AM COLL CARDIOL, V31, P62, DOI 10.1016/S0735-1097(97)00421-X
   Pepine C J, 1986, Cardiol Clin, V4, P577
   Pepine CJ, 2010, J AM COLL CARDIOL, V55, P2825, DOI 10.1016/j.jacc.2010.01.054
   Prior JO, 2007, EUR J NUCL MED MOL I, V34, P20, DOI 10.1007/s00259-006-0193-4
   Rosen SD, 2002, HEART, V87, P513, DOI 10.1136/heart.87.6.513
   Sestito A, 2011, J CARDIOVASC MED, V12, P322, DOI 10.2459/JCM.0b013e3283406479
   TAKI J, 1992, AM J CARDIOL, V70, P1555, DOI 10.1016/0002-9149(92)90456-9
   Valeriani M, 2000, CLIN NEUROPHYSIOL, V111, P1103, DOI 10.1016/S1388-2457(00)00273-X
   Valeriani M, 2005, EUR HEART J, V26, P975, DOI 10.1093/eurheartj/ehi229
   WILSON RF, 1990, CIRCULATION, V82, P1595, DOI 10.1161/01.CIR.82.5.1595
NR 30
TC 14
Z9 14
U1 0
U2 2
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
EI 1879-1913
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD JUN 15
PY 2012
VL 109
IS 12
BP 1705
EP 1710
DI 10.1016/j.amjcard.2012.02.012
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 964XE
UT WOS:000305729200004
PM 22459303
DA 2025-06-11
ER

PT J
AU Prinsloo, GE
   Rauch, HGL
   Derman, WE
AF Prinsloo, Gabriell E.
   Rauch, H. G. Laurie
   Derman, Wayne E.
TI A Brief Review and Clinical Application of Heart Rate Variability
   Biofeedback in Sports, Exercise, and Rehabilitation Medicine
SO PHYSICIAN AND SPORTSMEDICINE
LA English
DT Review
DE noncommunicable disease; psychosocial stress; heart rate variability;
   biofeedback
ID RESPIRATORY-SINUS-ARRHYTHMIA; POWER SPECTRAL-ANALYSIS; INDUCED
   MYOCARDIAL-ISCHEMIA; FREQUENCY-DOMAIN ANALYSIS; PSYCHOSOCIAL
   RISK-FACTORS; METABOLIC-SYNDROME; BLOOD-PRESSURE; BAROREFLEX
   SENSITIVITY; MENTAL STRESS; JOB STRAIN
AB Context: An important component of the effective management of chronic noncommunicable disease is the assessment and management of psychosocial stress. The measurement and modulation of heart rate variability (HRV) may be valuable in this regard. Objective: To describe the measurement and physiological control of HRV; to describe the impact of psychosocial stress on cardiovascular disease, metabolic syndrome, and chronic respiratory disease, and the relationship between these diseases and changes in HRV; and to describe the influence of biofeedback and exercise on HRV and the use of HRV biofeedback in the management of chronic disease. Data Sources and Study Selection: The PubMed, Medline, and Embase databases were searched (up to August 2013). Additional articles were obtained from the reference lists of relevant articles and reviews. Articles were individually selected for further review based on the quality and focus of the study, and the population studied. Results: Heart rate variability is reduced in stress and in many chronic diseases, and may even predict the development and prognosis of some diseases. Heart rate variability can be increased with both exercise and biofeedback. Although the research on the effect of exercise is conflicting, there is evidence that aerobic training may increase HRV and cardiac vagal tone both in healthy individuals and in patients with disease. Heart rate variability biofeedback is also an effective method of increasing HRV and cardiac vagal tone, and has been shown to decrease stress and reduce the morbidity and mortality of disease. Conclusion: The assessment and management of psychosocial stress is a challenging but important component of effective comprehensive lifestyle interventions for the management of noncommunicable disease. It is, therefore, important for the sports and exercise physician to have an understanding of the therapeutic use of HRV modulation, both in the reduction of stress and in the management of chronic disease.
C1 [Prinsloo, Gabriell E.; Rauch, H. G. Laurie; Derman, Wayne E.] Univ Cape Town, MRC, UCT Res Unit Exercise Sci & Sports Med, ZA-7725 Cape Town, South Africa.
   [Prinsloo, Gabriell E.; Derman, Wayne E.] IOC Res Ctr, Cape Town, South Africa.
C3 University of Cape Town
RP Prinsloo, GE (corresponding author), Univ Cape Town, Fac Hlth Sci, Dept Human Biol, MRC UCT Res Unit Exercise Sci & Sports Med, POB 115, ZA-7725 Cape Town, South Africa.
EM gabriellprinsloo@gmail.com
RI Derman, Wayne/ABD-6557-2020; Rauch, HG Laurie/HCI-8272-2022
OI Rauch, HG Laurie/0000-0002-7709-3407
CR Achten J, 2003, SPORTS MED, V33, P517, DOI 10.2165/00007256-200333070-00004
   Agelink MW, 2001, CLIN AUTON RES, V11, P99, DOI 10.1007/BF02322053
   Akashi YJ, 2005, EUR J HEART FAIL, V7, P1171, DOI 10.1016/j.ejheart.2005.03.011
   AlAni M, 1996, CLIN SCI, V90, P235, DOI 10.1042/cs0900235
   Arnold SV, 2012, J AM COLL CARDIOL, V60, P1756, DOI 10.1016/j.jacc.2012.06.044
   Aubert AE, 2003, SPORTS MED, V33, P889, DOI 10.2165/00007256-200333120-00003
   Bernardi L, 1998, LANCET, V351, P1308, DOI 10.1016/S0140-6736(97)10341-5
   BERNARDI L, 1994, CLIN SCI, V87, P649, DOI 10.1042/cs0870649
   Berntson GG, 1997, PSYCHOPHYSIOLOGY, V34, P623, DOI 10.1111/j.1469-8986.1997.tb02140.x
   Berntson GG, 2005, PSYCHOPHYSIOLOGY, V42, P246, DOI 10.1111/j.1469-8986.2005.00277.x
   BIGGER JT, 1991, J AM COLL CARDIOL, V18, P1643, DOI 10.1016/0735-1097(91)90497-W
   BIGGER JT, 1995, CIRCULATION, V91, P1936, DOI 10.1161/01.CIR.91.7.1936
   BIGGER JT, 1993, CIRCULATION, V88, P927, DOI 10.1161/01.CIR.88.3.927
   Billman GE, 2013, FRONT PHYSIOL, V4, DOI 10.3389/fphys.2013.00222
   Bjorntorp P, 1996, INT J OBESITY, V20, P291
   Bonnet F, 2005, ATHEROSCLEROSIS, V178, P339, DOI 10.1016/j.atherosclerosis.2004.08.035
   Braun C, 1998, AM J PHYSIOL-HEART C, V275, pH1577, DOI 10.1152/ajpheart.1998.275.5.H1577
   BRINDLEY DN, 1989, CLIN SCI, V77, P453, DOI 10.1042/cs0770453
   Brotman DJ, 2007, LANCET, V370, P1089, DOI 10.1016/S0140-6736(07)61305-1
   Camm AJ, 1996, EUR HEART J, V17, P354
   Cecchi E, 2013, AM J CARDIOL, V111, P1523, DOI 10.1016/j.amjcard.2013.01.304
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Chandola T, 2008, EUR HEART J, V29, P640, DOI 10.1093/eurheartj/ehm584
   Chen Z, 2010, IEEE T BIO-MED ENG, V57, P1335, DOI 10.1109/TBME.2010.2041002
   Cohen MA, 2002, J PHYSIOL-LONDON, V542, P669, DOI 10.1113/jphysiol.2002.017483
   Cooke WH, 1999, J PHYSIOL-LONDON, V517, P617, DOI 10.1111/j.1469-7793.1999.0617t.x
   COUNIHAN PJ, 1993, CIRCULATION, V88, P1682, DOI 10.1161/01.CIR.88.4.1682
   DEBOER RW, 1987, AM J PHYSIOL, V253, pH680, DOI 10.1152/ajpheart.1987.253.3.H680
   Dekker JM, 2000, CIRCULATION, V102, P1239, DOI 10.1161/01.CIR.102.11.1239
   Del Pozo JM, 2004, AM HEART J, V147, pG1, DOI 10.1016/j.ahj.2003.08.013
   Derman WE, 2011, CURR SPORT MED REP, V10, P316, DOI 10.1249/JSR.0b013e3182395c94
   Dimsdale JE, 2008, J AM COLL CARDIOL, V51, P1237, DOI 10.1016/j.jacc.2007.12.024
   Dolezal BA, 2013, MED SCI SPORTS EXERC, DOI [10.1249/MSS0000000000000201, DOI 10.1249/MSS0000000000000201]
   Ebben MR, 2009, APPL PSYCHOPHYS BIOF, V34, P245, DOI 10.1007/s10484-009-9086-1
   ECKBERG DL, 1985, J PHYSIOL-LONDON, V365, P181, DOI 10.1113/jphysiol.1985.sp015766
   Eckberg DL, 2003, J PHYSIOL-LONDON, V548, P339, DOI 10.1113/jphysiol.2002.037192
   Edwards EM, 2012, J OCCUP ENVIRON MED, V54, P1447, DOI 10.1097/JOM.0b013e3182783f27
   FEI L, 1994, BRIT HEART J, V71, P322
   Felder R.B., 1994, NUCLEUS SOLITARY TRA, P169
   Ferrie JE, 2013, ATHEROSCLEROSIS, V227, P178, DOI 10.1016/j.atherosclerosis.2012.12.027
   Fioranelli M, 1999, PACE, V22, P743, DOI 10.1111/j.1540-8159.1999.tb00538.x
   FOUAD FM, 1984, AM J PHYSIOL, V246, pH838, DOI 10.1152/ajpheart.1984.246.6.H838
   Friedman BH, 2007, BIOL PSYCHOL, V74, P185, DOI 10.1016/j.biopsycho.2005.08.009
   Gehi AK, 2009, J CARDIOVASC ELECTR, V20, P422, DOI 10.1111/j.1540-8167.2008.01363.x
   Giardino ND, 2004, APPL PSYCHOPHYS BIOF, V29, P121, DOI 10.1023/B:APBI.0000026638.64386.89
   Goldberg AD, 1996, CIRCULATION, V94, P2402, DOI 10.1161/01.CIR.94.10.2402
   Grasso R, 1997, J AUTONOM NERV SYST, V63, P30, DOI 10.1016/S0165-1838(96)00128-2
   Gunduz H, 2009, CARDIOL J, V16, P553
   GUZZETTI S, 1995, EUR HEART J, V16, P1100, DOI 10.1093/oxfordjournals.eurheartj.a061053
   Hansson Anders, 2004, BMC Cardiovasc Disord, V4, P13, DOI 10.1186/1471-2261-4-13
   Hassett AL, 2007, APPL PSYCHOPHYS BIOF, V32, P1, DOI 10.1007/s10484-006-9028-0
   Houle MS, 1999, AM J PHYSIOL-HEART C, V276, pH215, DOI 10.1152/ajpheart.1999.276.1.H215
   Huang JL, 1998, INT J CARDIOL, V66, P275, DOI 10.1016/S0167-5273(98)00241-1
   Huikuri HV, 1996, AM J CARDIOL, V77, P1073, DOI 10.1016/S0002-9149(96)00135-X
   HUIKURI HV, 1993, CIRCULATION, V87, P1220, DOI 10.1161/01.CIR.87.4.1220
   Iellamo F, 2013, INT J CARDIOL, V166, P334, DOI 10.1016/j.ijcard.2011.10.082
   INNES JA, 1993, J PHYSIOL-LONDON, V460, P487, DOI 10.1113/jphysiol.1993.sp019483
   Jiang W, 2013, J AM COLL CARDIOL, V61, P714, DOI 10.1016/j.jacc.2012.11.037
   Joseph CN, 2005, HYPERTENSION, V46, P714, DOI 10.1161/01.HYP.0000179581.68566.7d
   Julien C, 2006, CARDIOVASC RES, V70, P12, DOI 10.1016/j.cardiores.2005.11.008
   Karavidas MK, 2007, APPL PSYCHOPHYS BIOF, V32, P19, DOI 10.1007/s10484-006-9029-z
   KIRCHHEIM HR, 1976, PHYSIOL REV, V56, P100, DOI 10.1152/physrev.1976.56.1.100
   Kivimäki M, 2012, LANCET, V380, P1491, DOI 10.1016/S0140-6736(12)60994-5
   Kivimäki M, 2002, BRIT MED J, V325, P857, DOI 10.1136/bmj.325.7369.857
   Kleiger RE, 2005, ANN NONINVAS ELECTRO, V10, P88, DOI 10.1111/j.1542-474X.2005.10101.x
   KLEIGER RE, 1987, AM J CARDIOL, V59, P256, DOI 10.1016/0002-9149(87)90795-8
   Kop WJ, 2001, J AM COLL CARDIOL, V38, P742, DOI 10.1016/S0735-1097(01)01451-6
   Krantz David S., 1996, Cardiology Clinics, V14, P271
   La Rovere MT, 2002, CIRCULATION, V106, P945, DOI 10.1161/01.CIR.0000027565.12764.E1
   La Rovere MT, 1998, LANCET, V351, P478
   Lahiri MK, 2008, J AM COLL CARDIOL, V51, P1725, DOI 10.1016/j.jacc.2008.01.038
   Lampert R, 2000, CIRCULATION, V101, P158, DOI 10.1161/01.CIR.101.2.158
   Landsbergis PA, 2013, AM J PUBLIC HEALTH, V103, pE61, DOI 10.2105/AJPH.2012.301153
   Lane RD, 2005, PSYCHOSOM MED, V67, P359, DOI 10.1097/01.psy.0000160476.67536.41
   Lehrer F, 2006, CHEST, V129, P278, DOI 10.1378/chest.129.2.278
   Lehrer P, 2002, J CONSULT CLIN PSYCH, V70, P691, DOI 10.1037//0022-006X.70.3.691
   Lehrer P, 2010, APPL PSYCHOPHYS BIOF, V35, P303, DOI 10.1007/s10484-010-9139-5
   Lehrer PM, 2004, CHEST, V126, P352, DOI 10.1378/chest.126.2.352
   Lehrer PM, 2000, APPL PSYCHOPHYS BIOF, V25, P177, DOI 10.1023/A:1009554825745
   LEVY MN, 1990, ANN NY ACAD SCI, V601, P209
   Lewis MJ, 2010, SCAND J MED SCI SPOR, V20, P794, DOI 10.1111/j.1600-0838.2010.01150.x
   LIAO DP, 1995, AM J CARDIOL, V76, P906, DOI 10.1016/S0002-9149(99)80260-4
   Liao DP, 1996, AM J HYPERTENS, V9, P1147, DOI 10.1016/S0895-7061(96)00249-X
   Luskin Frederic, 2002, Prev Cardiol, V5, P168, DOI 10.1111/j.1520.037X.2002.01029.x
   Maestri R, 2010, CLIN SCI, V118, P195, DOI 10.1042/CS20090183
   Malfatto G, 1996, EUR HEART J, V17, P532
   MALLIANI A, 1991, CIRCULATION, V84, P482, DOI 10.1161/01.CIR.84.2.482
   Malpas SC, 2002, AM J PHYSIOL-HEART C, V282, pH6, DOI 10.1152/ajpheart.2002.282.1.H6
   Martinmäki K, 2006, AM J PHYSIOL-HEART C, V290, pH640, DOI 10.1152/ajpheart.00054.2005
   McCraty R, 2003, J ALTERN COMPLEM MED, V9, P355, DOI 10.1089/107555303765551589
   Médigue C, 2001, PFLUG ARCH EUR J PHY, V441, P650, DOI 10.1007/s004240000486
   Mikosch P, 2010, J ADV NURS, V66, P1101, DOI 10.1111/j.1365-2648.2010.05277.x
   Min KB, 2008, PACE, V31, P584, DOI 10.1111/j.1540-8159.2008.01045.x
   Miu AC, 2009, AUTON NEUROSCI-BASIC, V145, P99, DOI 10.1016/j.autneu.2008.11.010
   Moak Jeffrey P, 2009, Cleve Clin J Med, V76 Suppl 2, pS51, DOI 10.3949/ccjm.76.s2.11
   Moravec Christine S, 2008, Cleve Clin J Med, V75 Suppl 2, pS35
   MORTARA A, 1994, BRIT HEART J, V71, P422
   Neylon A, 2013, PROG CARDIOVASC DIS, V55, P574, DOI 10.1016/j.pcad.2013.03.009
   Nolan RP, 2005, AM HEART J, V149, DOI 10.1016/j.ahj.2005.03.015
   NOVAK V, 1995, J CLIN NEUROPHYSIOL, V12, P64
   Nunan D, 2010, PACE, V33, P1407, DOI 10.1111/j.1540-8159.2010.02841.x
   PAGANI M, 1988, J AUTONOM NERV SYST, V23, P143, DOI 10.1016/0165-1838(88)90078-1
   Pagani M, 1997, CIRCULATION, V95, P1441
   PAGANI M, 1986, CIRC RES, V59, P178, DOI 10.1161/01.RES.59.2.178
   Peacock J, 2013, PROG CARDIOVASC DIS, V55, P582, DOI 10.1016/j.pcad.2013.03.001
   Penttilä J, 2001, CLIN PHYSIOL, V21, P365, DOI 10.1046/j.1365-2281.2001.00337.x
   PFEIFER MA, 1984, DIABETES CARE, V7, P447, DOI 10.2337/diacare.7.5.447
   Pinna GD, 2007, CLIN SCI, V113, P131, DOI 10.1042/CS20070055
   Ponikowski P, 1997, AM J CARDIOL, V79, P1645, DOI 10.1016/S0002-9149(97)00215-4
   Poon CS, 1997, NATURE, V389, P492, DOI 10.1038/39043
   Porges SW, 2007, BIOL PSYCHOL, V74, P116, DOI 10.1016/j.biopsycho.2006.06.009
   Pyykkönen AJ, 2010, DIABETES CARE, V33, P378, DOI 10.2337/dc09-1027
   RATHMANN W, 1993, DIABETIC MED, V10, P820, DOI 10.1111/j.1464-5491.1993.tb00173.x
   Rod NH, 2012, ALLERGY, V67, P1408, DOI [10.1111/j.1398-9995.2012.02882.x, 10.1111/j.1398-9995.2012.02882.x.]
   Rosengren A, 2004, LANCET, V364, P953, DOI 10.1016/S0140-6736(04)17019-0
   Routledge FS, 2010, CAN J CARDIOL, V26, P303, DOI 10.1016/S0828-282X(10)70395-0
   ROZANSKI A, 1988, NEW ENGL J MED, V318, P1005, DOI 10.1056/NEJM198804213181601
   Sacha J, 2008, INT J CARDIOL, V128, P444, DOI 10.1016/j.ijcard.2007.06.047
   Sacha J, 2013, FRONT PHYSIOL, V4, DOI 10.3389/fphys.2013.00306
   Sandercock GRH, 2006, SCAND J MED SCI SPOR, V16, P302, DOI 10.1111/j.1600-0838.2006.00556.x
   Sandercock GRH, 2006, PACE, V29, P892, DOI 10.1111/j.1540-8159.2006.00457.x
   Sandercock GRH, 2005, INT J CARDIOL, V103, P238, DOI 10.1016/j.ijcard.2004.09.013
   SAUL JP, 1990, AM J PHYSIOL, V258, pH713, DOI 10.1152/ajpheart.1990.258.3.H713
   SAUL JP, 1991, AM J PHYSIOL, V261, pH1231, DOI 10.1152/ajpheart.1991.261.4.H1231
   Schroeder EB, 2004, J ELECTROCARDIOL, V37, P163, DOI 10.1016/j.jelectrocard.2004.04.004
   Schroeder EB, 2003, HYPERTENSION, V42, P1106, DOI 10.1161/01.HYP.0000100444.71069.73
   Schwartz AR, 2003, PSYCHOSOM MED, V65, P22, DOI 10.1097/01.PSY.0000046075.79922.61
   SCHWARTZ PJ, 1992, CIRCULATION, V85, P77
   Sharma Ajay K, 2011, Crit Pathw Cardiol, V10, P142, DOI 10.1097/HPC.0b013e31822f4d37
   Sherlin L, 2009, INT J STRESS MANAGE, V16, P233, DOI 10.1037/a0016047
   Shusterman V., 1997, AM J PHYSIOL-REG I, V273, P1173
   Singh JP, 2000, AM J CARDIOL, V86, P309, DOI 10.1016/S0002-9149(00)00920-6
   SLEIGHT P, 1995, CLIN SCI, V88, P103, DOI 10.1042/cs0880103
   Slovut DP, 1998, CLIN EXP PHARMACOL P, V25, P322, DOI 10.1111/j.1440-1681.1998.tb02358.x
   Soares-Miranda L, 2012, DIABETES-METAB RES, V28, P363, DOI 10.1002/dmrr.2281
   Soufer R, 2004, CIRCULATION, V110, P1710, DOI 10.1161/01.CIR.0000144841.84987.50
   Stein PK, 2007, DIABETIC MED, V24, P855, DOI 10.1111/j.1464-5491.2007.02163.x
   Stein PK, 1998, CHEST, V113, P327, DOI 10.1378/chest.113.2.327
   Swanson KS, 2009, APPL PSYCHOPHYS BIOF, V34, P71, DOI 10.1007/s10484-009-9077-2
   TAHA BH, 1995, J APPL PHYSIOL, V78, P638, DOI 10.1152/jappl.1995.78.2.638
   Tamashiro KLK, 2011, ANN NY ACAD SCI, V1231, P46, DOI 10.1111/j.1749-6632.2011.06134.x
   Taylor JA, 1998, CIRCULATION, V98, P547, DOI 10.1161/01.CIR.98.6.547
   Taylor JA, 2001, AM J PHYSIOL-HEART C, V280, pH2804, DOI 10.1152/ajpheart.2001.280.6.H2804
   Thayer JF, 2010, INT J CARDIOL, V141, P122, DOI 10.1016/j.ijcard.2009.09.543
   TOSKA K, 1993, J PHYSIOL-LONDON, V472, P501, DOI 10.1113/jphysiol.1993.sp019958
   TRIEDMAN JK, 1994, CIRCULATION, V89, P169, DOI 10.1161/01.CIR.89.1.169
   Tsai YS, 2011, J CLIN NURS, V20, P111, DOI 10.1111/j.1365-2702.2010.03397.x
   Tsuji H, 1996, CIRCULATION, V94, P2850, DOI 10.1161/01.CIR.94.11.2850
   Uusitalo A, 2011, APPL ERGON, V42, P830, DOI 10.1016/j.apergo.2011.01.005
   van Gestel AJR, 2011, RESPIROLOGY, V16, P939, DOI 10.1111/j.1440-1843.2011.01992.x
   VANOLI E, 1990, BASIC RES CARDIOL, V85, P305
   Vanravenswaaijarts CMA, 1993, ANN INTERN MED, V118, P436, DOI 10.7326/0003-4819-118-6-199303150-00008
   Vaschillo E, 2004, CHEST, V126, P1385, DOI 10.1016/S0012-3692(15)31329-5
   Vaschillo E, 2002, APPL PSYCHOPHYS BIOF, V27, P1, DOI 10.1023/A:1014587304314
   Vaschillo EG, 2006, APPL PSYCHOPHYS BIOF, V31, P129, DOI 10.1007/s10484-006-9009-3
   Vig RS, 2006, ANN NY ACAD SCI, V1088, P65, DOI 10.1196/annals.1366.023
   Vincenti A, 2006, EUROPACE, V8, P204, DOI 10.1093/europace/euj043
   VOLTERRANI M, 1994, CHEST, V106, P1432, DOI 10.1378/chest.106.5.1432
   Voss A, 2009, PHILOS T R SOC A, V367, P277, DOI 10.1098/rsta.2008.0232
   Wen ZC, 1998, J AM COLL CARDIOL, V31, P602, DOI 10.1016/S0735-1097(97)00555-X
   Wheat AL, 2010, APPL PSYCHOPHYS BIOF, V35, P229, DOI 10.1007/s10484-010-9133-y
   World Health Organization. WHO, 2011, GLOBAL STATUS REPORT
   Wu GQ, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004323
   Xhyheri B, 2012, PROG CARDIOVASC DIS, V55, P321, DOI 10.1016/j.pcad.2012.09.001
NR 164
TC 72
Z9 87
U1 2
U2 84
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0091-3847
EI 2326-3660
J9 PHYSICIAN SPORTSMED
JI Physician Sportsmed.
PD MAY
PY 2014
VL 42
IS 2
BP 88
EP 99
DI 10.3810/psm.2014.05.2061
PG 12
WC Primary Health Care; Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine; Orthopedics; Sport Sciences
GA AR2FM
UT WOS:000343399000009
PM 24875976
DA 2025-06-11
ER

PT J
AU Chueakula, N
   Jaikumkao, K
   Arjinajarn, P
   Pongchaidecha, A
   Chatsudthipong, V
   Chattipakorn, N
   Lungkaphin, A
AF Chueakula, Nuttawud
   Jaikumkao, Krit
   Arjinajarn, Phatchawan
   Pongchaidecha, Anchalee
   Chatsudthipong, Varanuj
   Chattipakorn, Nipon
   Lungkaphin, Anusorn
TI Diacerein alleviates kidney injury through attenuating inflammation and
   oxidative stress in obese insulin-resistant rats
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Diacerein; Inflammation; Insulin resistance; Kidney function; Oxidative
   stress
ID ORGANIC ION TRANSPORTERS; HIGH-FAT DIET; METABOLIC SYNDROME;
   ADIPOSE-TISSUE; HYDROGEN-PEROXIDE; ANGIOTENSIN-II; RENAL-FUNCTION;
   DISEASE; EXPRESSION; DIACERHEIN
AB A link between inflammation with obesity and metabolic syndrome has been found in patients with chronic kidney disease (CKD). Diacerein is an anthraquinone used to treat osteoarthritis that exerts anti-inflammatory action by inhibiting the synthesis and activity of proinflammatory cytokines. This study aimed to investigate the protective effect of diacerein on renal function and renal organic anion transporter 3 (Oat3) function in obese insulin-resistant condition. Obese insulin-resistant rats were induced by feeding a high-fat diet in male Wistar rats for 16 weeks. Diacerein or metformin (positive control) (30 mg/kg/day) was administered orally for 4 weeks after insulin resistance had been confirmed. Obese insulin-resistant rats showed an impaired renal function as indicated by the increased serum creatinine and microalbuminuria along with the decreased renal Oat3 function and expression. Importantly, diacerein treatment not only improved insulin resistance but also restored renal function. The decreased renal malondialdehyde level, expressions of PKC alpha, angiotensin 1 receptor (AT1R), Nrf2, and HO-1, and increased expression of SOD2 were observed in diacerein treatment group, indicating the attenuation of renal oxidative stress condition. Moreover, renal inflammation and renal damage were also alleviated in diacerein-treated rats. Our results demonstrated for the first time that diacerein was effective to improve renal function and renal Oat3 function in obese insulin-resistance condition mediated by suppressing renal oxidative stress and inflammation. These findings suggest that anti-inflammatory agents can be used therapeutically to improve metabolic disorder and prevent organ dysfunctions in pre-diabetic condition.
C1 [Chueakula, Nuttawud; Jaikumkao, Krit; Pongchaidecha, Anchalee; Chattipakorn, Nipon; Lungkaphin, Anusorn] Chiang Mai Univ, Dept Physiol, Fac Med, Chiang Mai 50200, Thailand.
   [Arjinajarn, Phatchawan] Chiang Mai Univ, Dept Biol, Fac Sci, Chiang Mai, Thailand.
   [Chatsudthipong, Varanuj] Mahidol Univ, Dept Physiol, Fac Sci, Bangkok, Thailand.
   [Chattipakorn, Nipon] Chiang Mai Univ, Cardiac Electrophysiol Res & Training Ctr, Fac Med, Chiang Mai, Thailand.
C3 Chiang Mai University; Chiang Mai University; Mahidol University; Chiang
   Mai University
RP Lungkaphin, A (corresponding author), Chiang Mai Univ, Dept Physiol, Fac Med, Chiang Mai 50200, Thailand.
EM onanusorn@yahoo.com
RI Jaikumkao, Krit/IUN-9587-2023; ARJINAJARN, PHATCHAWAN/GNM-8700-2022;
   Chattipakorn, Nipon/AAJ-4049-2021
OI Chattipakorn, Nipon/0000-0003-3026-718X
FU Thailand Research Fund [RSA6080015]; Faculty of Medicine Research Fund,
   Chiang Mai University [041-2561]; Center for Research and Development of
   Natural Products for Health; NSTDA Research Chair grant from the
   National Science and Technology Development Agency of Thailand
FX This work was supported by the Thailand Research Fund (RSA6080015) (AL),
   the Faculty of Medicine Research Fund, Chiang Mai University (041-2561)
   (AL and AP), Center for Research and Development of Natural Products for
   Health, and the NSTDA Research Chair grant from the National Science and
   Technology Development Agency of Thailand (NC).
CR [Anonymous], COCHRANE DATABASE SY
   Apaijai N, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0102374
   Arima S, 2003, J AM SOC NEPHROL, V14, P2255, DOI 10.1097/01.ASN.0000083982.74108.54
   Banday AA, 2008, AM J PHYSIOL-RENAL, V295, pF698, DOI 10.1152/ajprenal.90308.2008
   Bastard JP, 2006, EUR CYTOKINE NETW, V17, P4
   Bharti R, 2016, ONCOGENE, V35, P3965, DOI 10.1038/onc.2015.466
   Boutaud A, 2000, J BIOL CHEM, V275, P30716, DOI 10.1074/jbc.M004569200
   Burckhardt G, 2011, HANDB EXP PHARMACOL, V201, P29, DOI 10.1007/978-3-642-14541-4_2
   Cardoso CRL, 2017, DIABETES CARE, V40, P1356, DOI 10.2337/dc17-0374
   Chang JW, 2005, NEPHRON EXP NEPHROL, V101, pE165, DOI 10.1159/000087940
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Declèves AE, 2015, CURR OPIN NEPHROL HY, V24, P28, DOI 10.1097/MNH.0000000000000087
   Deji N, 2009, AM J PHYSIOL-RENAL, V296, pF118, DOI 10.1152/ajprenal.00110.2008
   DeMarco VG, 2014, NAT REV ENDOCRINOL, V10, P364, DOI 10.1038/nrendo.2014.44
   Dougados M, 2001, ARTHRITIS RHEUM-US, V44, P2539, DOI 10.1002/1529-0131(200111)44:11<2539::AID-ART434>3.0.CO;2-T
   Fazeli G, 2012, MUTAGENESIS, V27, P673, DOI 10.1093/mutage/ges033
   Feng MJ, 2008, AM J HYPERTENS, V21, P1288, DOI 10.1038/ajh.2008.301
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Gustafson B, 2010, J ATHEROSCLER THROMB, V17, P332, DOI 10.5551/jat.3939
   Habu Y, 2005, BIOCHEM PHARMACOL, V69, P993, DOI 10.1016/j.bcp.2004.12.004
   Jaikumkao K, 2016, EXP PHYSIOL, V101, P743, DOI 10.1113/EP085571
   Jatwa R, 2009, FUND CLIN PHARMACOL, V23, P465, DOI 10.1111/j.1472-8206.2009.00685.x
   Kamei N, 2006, J BIOL CHEM, V281, P26602, DOI 10.1074/jbc.M601284200
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Knight SF, 2007, MICROCIRCULATION, V14, P349, DOI 10.1080/10739680701283018
   Kobayashi M, 2005, ANTIOXID REDOX SIGN, V7, P385, DOI 10.1089/ars.2005.7.385
   Kovesdy CP, 2017, BLOOD PURIFICAT, V43, P346, DOI 10.1159/000458481
   Kurella M, 2005, J AM SOC NEPHROL, V16, P2134, DOI 10.1681/ASN.2005010106
   Li CX, 2015, AM J PHYSIOL-ENDOC M, V309, pE802, DOI 10.1152/ajpendo.00158.2015
   Malaguti C, 2008, INT IMMUNOPHARMACOL, V8, P782, DOI 10.1016/j.intimp.2008.01.020
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mendes AF, 2002, PHARMACOL TOXICOL, V91, P22, DOI 10.1034/j.1600-0773.2002.910104.x
   Méndez-del Villar M, 2017, ARCH ENDOCRIN METAB, V61, P188, DOI 10.1590/2359-3997000000242
   Moreno-Manzano V, 2000, J BIOL CHEM, V275, P12684, DOI 10.1074/jbc.275.17.12684
   Motohashi H, 2002, J AM SOC NEPHROL, V13, DOI 10.1681/ASN.V134866
   Mount P, 2015, METABOLITES, V5, P720, DOI 10.3390/metabo5040720
   Nair AR, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0111976
   Nicolas P, 1998, CLIN PHARMACOKINET, V35, P347, DOI 10.2165/00003088-199835050-00002
   Palaniappan L, 2003, AM J HYPERTENS, V16, P952, DOI 10.1016/S0895-7061(03)01009-4
   Phatchawan A, 2014, AM J MED SCI, V347, P221, DOI 10.1097/MAJ.0b013e3182831740
   Piovesan F, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0186554
   Promsan S., 2016, CAN J PHYSL PHARM, V29, P1
   Quintao NLM, 2005, ANESTH ANALG, V101, P1763, DOI 10.1213/01.ane.0000184182.03203.61
   Refaie MMM, 2016, J TOXICOL-US, V2016, DOI 10.1155/2016/9507563
   Ruan XZ, 2009, J DIABETES, V1, P236, DOI 10.1111/j.1753-0407.2009.00042.x
   SENN S, 1990, BRIT MED J, V300, P680, DOI 10.1136/bmj.300.6725.680
   Sharma K, 2013, J AM SOC NEPHROL, V24, P1901, DOI 10.1681/ASN.2013020126
   Sun ZJ, 2015, HYPERTENSION, V65, P252, DOI 10.1161/HYPERTENSIONAHA.114.03617
   Takeda M, 2000, LIFE SCI, V67, pPL1087, DOI 10.1016/S0024-3205(00)00694-9
   Tamura T, 2001, PHARMACOLOGY, V63, P228, DOI 10.1159/000056138
   Tobar N, 2011, ENDOCRINOLOGY, V152, P4080, DOI 10.1210/en.2011-0249
   Toke A, 2001, CONTRIB NEPHROL, V135, P34
   Torina AG, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0121842
   Tunapong W, 2018, EUR J NUTR, V57, P2091, DOI 10.1007/s00394-017-1482-3
   Vaziri ND, 2007, J PHARMACOL EXP THER, V323, P85, DOI 10.1124/jpet.107.123638
   Wahba IM, 2007, CLIN J AM SOC NEPHRO, V2, P550, DOI 10.2215/CJN.04071206
   Wang YX, 2013, J BIOL CHEM, V288, P12852, DOI 10.1074/jbc.M112.410357
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Wellen KE, 2003, J CLIN INVEST, V112, P1785, DOI 10.1172/JCI20514
   Xu MX, 2017, INT J NANOMED, V12, P327, DOI 10.2147/IJN.S116010
   Yu C, 2015, SCI REP-UK, V5, DOI 10.1038/srep11822
   Zeisberg M, 2001, AM J PATHOL, V159, P1313, DOI 10.1016/S0002-9440(10)62518-7
   Zhao YL, 2011, FOOD CHEM TOXICOL, V49, P1705, DOI 10.1016/j.fct.2011.04.011
   Zheng HT, 2011, DIABETES, V60, P3055, DOI 10.2337/db11-0807
   Zhou XM, 2004, KIDNEY INT, V65, P139, DOI 10.1111/j.1523-1755.2004.00380.x
   Zhou YX, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/578107
   Zou Y, 2013, FREE RADICAL RES, V47, P55, DOI 10.3109/10715762.2012.742518
NR 67
TC 45
Z9 46
U1 0
U2 28
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD FEB 1
PY 2018
VL 115
BP 146
EP 155
DI 10.1016/j.freeradbiomed.2017.11.021
PG 10
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA FS3UN
UT WOS:000419709200014
PM 29195834
DA 2025-06-11
ER

PT J
AU Al-Hawary, SIS
   Alzahrani, AA
   Maabreh, HG
   Jawad, MA
   Alsaadi, SB
   Jabber, NK
   Alawadi, A
   Alsalamy, A
   Alizadeh, F
AF Al-Hawary, Sulieman Ibraheem Shelash
   Alzahrani, Abdullah Ali
   Maabreh, Hatem Ghaleb
   Jawad, Mohammed Abed
   Alsaadi, Salim B.
   Jabber, Noura Kareem
   Alawadi, Ahmed
   Alsalamy, Ali
   Alizadeh, Farideh
TI The association of metabolic syndrome with telomere length as a marker
   of cellular aging: a systematic review and meta-analysis
SO FRONTIERS IN GENETICS
LA English
DT Review
DE metabolic syndrome; telomere length; telomerase; aging; meta-analysis
ID PHYSICAL-ACTIVITY; OXIDATIVE STRESS; COMPONENTS; DISEASE; OBESITY; RISK
AB Background: It has been suggested that metabolic syndrome (MetS) accelerates the aging process, potentially contributing to the development of age-related complications. Available studies examining the relation of MetS to telomere length (TL), a putative biological marker of aging, have yielded inconclusive findings. This meta-analysis was performed to investigate the association between MetS and TL. Methods: A comprehensive systematic search was conducted in PubMed and Scopus databases to identify relevant literature published up to February 2024. Standard mean difference (SMD) and standardized beta coefficient (beta) with their 95% confidence intervals (CI) were used as effect sizes to measure the associations using the random effects model. Results: A total of nine studies, comprising a total sample size of 8,606 participants, were eligible for the meta-analysis. No significant difference in mean TL was found between patients with and without MetS (SMD = -0.03, 95%CI = -0.17 to 0.10), with a significant heterogeneity across the studies (I-2 = 89.7.0%, p <= 0.001). In contrast, it was revealed that MetS is negatively related to TL (beta = -0.08, 95%CI = -0.15 to -0.004). In the subgroup analysis, this finding was supported by the International Diabetes Federation (IDF) definition of MetS. Conclusion: This meta-analysis highlighted that MetS may be linked to a shorter TL. Additional studies are required to confirm this finding.
C1 [Al-Hawary, Sulieman Ibraheem Shelash] Al Al Bayt Univ, Business Sch, Dept Business Adm, Mafraq, Jordan.
   [Alzahrani, Abdullah Ali] Taif Univ, Dept Surg, Taif, Saudi Arabia.
   [Maabreh, Hatem Ghaleb] RUDN Univ, Patrice Lumumba Peoples Friendship Univ Russia, Dept Dermatovenerol Foreign Languages, Moscow, Russia.
   [Jawad, Mohammed Abed] Al Nisour Univ Coll, Dept Pharmaceut, Baghdad, Iraq.
   [Alsaadi, Salim B.] Al Hadi Univ Coll, Dept Pharmaceut, Baghdad, Iraq.
   [Jabber, Noura Kareem] Al Ayen Univ, Coll Hlth & Med Technol, Nasiriyah, Iraq.
   [Alawadi, Ahmed] Islamic Univ, Coll Tech Engn, Najaf, Iraq.
   [Alawadi, Ahmed] Islamic Univ Al Diwaniyah, Coll Tech Engn, Al Diwaniyah, Iraq.
   [Alawadi, Ahmed] Islamic Univ Babylon, Coll Tech Engn, Babylon, Iraq.
   [Alsalamy, Ali] Imam Jaafar Al Sadiq Univ, Coll Tech Engn, Samawah, Iraq.
   [Alizadeh, Farideh] Univ Tehran Med Sci, Dept Med, Tehran, Iran.
C3 Al al-Bayt University; Taif University; Peoples Friendship University of
   Russia; Al-Nisour University College; Al-Ayen University; Islamic
   University College; University of Babylon; Imam Jaa'far al-Sadiq
   University; Tehran University of Medical Sciences
RP Alizadeh, F (corresponding author), Univ Tehran Med Sci, Dept Med, Tehran, Iran.
EM farabora2022@gmail.com
RI Al-Hawary, Sulieman/B-3115-2013
CR Alizadeh S, 2018, INT J CLIN PRACT, V72, DOI 10.1111/ijcp.13201
   Arsenis NC, 2017, ONCOTARGET, V8, P45008, DOI 10.18632/oncotarget.16726
   Carulli L, 2016, MOL GENET METAB, V118, P138, DOI 10.1016/j.ymgme.2016.04.003
   Cheng YY, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0180687
   Denham J, 2016, SPORTS MED, V46, P1213, DOI 10.1007/s40279-016-0482-4
   DerSimonian R, 2007, CONTEMP CLIN TRIALS, V28, P105, DOI 10.1016/j.cct.2006.04.004
   Devrajani T, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-44715-1
   Moreira NCD, 2020, DIABETES METAB SYND, V14, P1217, DOI 10.1016/j.dsx.2020.05.043
   Dragovic G, 2021, EXP GERONTOL, V147, DOI 10.1016/j.exger.2021.111269
   Emami MR, 2021, SURG OBES RELAT DIS, V17, P1621, DOI 10.1016/j.soard.2021.05.003
   Fernandes SG, 2021, ENVIRON TOXICOL PHAR, V85, DOI 10.1016/j.etap.2021.103633
   Gavia-García G, 2021, BIOLOGY-BASEL, V10, DOI 10.3390/biology10040253
   Gelius P, 2020, PREV MED REP, V18, DOI 10.1016/j.pmedr.2020.101095
   Grun LK, 2018, FREE RADICAL BIO MED, V129, P286, DOI 10.1016/j.freeradbiomed.2018.09.039
   Holven KB, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0078241
   Hosseinzadeh A, 2020, OBES SURG, V30, P4046, DOI 10.1007/s11695-020-04807-7
   Huang YC, 2022, WORLD J BIOL PSYCHIA, V23, P483, DOI 10.1080/15622975.2021.2013091
   Huzen J, 2014, J INTERN MED, V275, P155, DOI 10.1111/joim.12149
   Molli AEI, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0174945
   Irandoust K, 2018, INT ARCH HEALTH SCI, V5, P145, DOI 10.4103/iahs.iahs_40_18
   Jurk D, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms5172
   Kirchner H, 2017, GENES-BASEL, V8, DOI 10.3390/genes8070176
   Kolb H, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1261298
   Lejawa M, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10010093
   Liu HH, 2015, AGEING RES REV, V19, P43, DOI 10.1016/j.arr.2014.12.001
   Loh NY, 2023, OBESITY, V31, P2189, DOI 10.1002/oby.23810
   Ludlow AT, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/601368
   Mather KA, 2011, J GERONTOL A-BIOL, V66, P202, DOI 10.1093/gerona/glq180
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Mundstock E, 2015, OBESITY, V23, P2165, DOI 10.1002/oby.21183
   Organization W. H., 2023, Promot. Phys. activity healthy diets healthy ageing WHO Eur. Region
   Paul L, 2011, J NUTR BIOCHEM, V22, P895, DOI 10.1016/j.jnutbio.2010.12.001
   Peng XM, 2021, J RES MED SCI, V26, DOI 10.4103/jrms.JRMS_793_20
   Peters JL, 2006, JAMA-J AM MED ASSOC, V295, P676, DOI 10.1001/jama.295.6.676
   Rashidbeygi E, 2019, DIAB MET SYND CLIN R, V13, P830, DOI 10.1016/j.dsx.2018.12.006
   Razi B, 2017, DIAB MET SYND CLIN R, V11, pS939, DOI 10.1016/j.dsx.2017.07.020
   Rehkopf DH, 2016, PLOS MED, V13, DOI 10.1371/journal.pmed.1002188
   Révész D, 2015, J CLIN ENDOCR METAB, V100, P3050, DOI 10.1210/JC.2015-1995
   Révész D, 2014, J CLIN ENDOCR METAB, V99, P4607, DOI 10.1210/jc.2014-1851
   Satoh M, 2008, ATHEROSCLEROSIS, V198, P347, DOI 10.1016/j.atherosclerosis.2007.09.040
   Schneider CV, 2022, JAMA INTERN MED, V182, P291, DOI 10.1001/jamainternmed.2021.7804
   Shen CY, 2023, TRANSL PSYCHIAT, V13, DOI 10.1038/s41398-023-02515-1
   Shin YA, 2019, J OBES METAB SYNDR, V28, P92, DOI 10.7570/jomes.2019.28.2.92
   Spahis S, 2017, ANTIOXID REDOX SIGN, V26, P445, DOI 10.1089/ars.2016.6756
   Sutherland JP, 2004, METAB SYNDR RELAT D, V2, P82, DOI 10.1089/met.2004.2.82
   Uziel O, 2013, ANN TRANSPL, V18, P567, DOI 10.12659/AOT.889272
   Vendrell J, 2004, OBES RES, V12, P962, DOI 10.1038/oby.2004.118
   Vishram JKK, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0107294
   Von Zglinicki T, 2000, ANN NY ACAD SCI, V908, P99, DOI 10.1111/j.1749-6632.2000.tb06639.x
   Weischer M, 2013, JNCI-J NATL CANCER I, V105, P459, DOI 10.1093/jnci/djt016
   Wells G., 2016, Ott. Hosp. Res. Inst. Clin. Epidemiol
   Whittemore K, 2019, P NATL ACAD SCI USA, V116, P15122, DOI 10.1073/pnas.1902452116
   Wong JYY, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0087348
   Yagmaee F., 2021, INT J SPORT STUD HLT, V4, DOI [10.5812/intjssh.121345, DOI 10.5812/INTJSSH.121345]
   Zhu HD, 2011, J PEDIATR-US, V158, P215, DOI 10.1016/j.jpeds.2010.08.007
NR 55
TC 1
Z9 1
U1 0
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-8021
J9 FRONT GENET
JI Front. Genet.
PD JUL 9
PY 2024
VL 15
AR 1390198
DI 10.3389/fgene.2024.1390198
PG 11
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA ZH3V1
UT WOS:001274375100001
PM 39045323
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Montoya-Alatriste, CA
   Alarcon-Aguilar, FJ
AF Ali Montoya-Alatriste, Claudia
   Javier Alarcon-Aguilar, Francisco
TI Cannabis and cannabinoids as an alternative remedy in metabolic
   syndrome
SO BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Cannabis; Cannabinoids; Metabolic syndrome; CB1 antagonists;
   Cannabidiol; Diabetes mellitus
ID ENDOCANNABINOID SYSTEM; DIABETES-MELLITUS; OXIDATIVE STRESS; MARIJUANA
   USE; RECEPTOR; INSULIN; GLUCOSE; CB1; EXPRESSION; SECRETION
AB Metabolic syndrome (MetS), an epidemic defined as a group of interconnected physiological, biochemistry, clinical, and metabolic factors, directly increases the risk of cardiovascular disease, atherosclerosis, type 2 diabetes, and death. MetS therapy includes diet, physical exercise, and a poly-pharmacological intervention. Cannabis is mainly recognized for its recreational uses and has several medical applications for neurological diseases, due to its hypnotic, anxiolytic, antinociceptive, anti-inflammatory, and anticonvulsant activities. Although several clinical observations in Cannabis smokers suggest metabolic effects, its utility in metabolic disorders is unclear. This review aims to determine under what conditions Cannabis might be useful in the treatment of MetS. Cannabis contains 120 phytocannabinoids, of which Delta(9)-THC mediates its psychoactive effects. Cannabinoids exert biological effects through interactions with the endocannabinoid system, which modulates several physiologic and metabolic pathways through cannabinoid receptors (CB1/CB2). Signaling through both receptors inhibits neurotransmitter release. In general, endocannabinoid system stimulation in Cannabis smokers and Delta(9)-THC signaling through CB1 have been implicated in MetS development, obesity, and type 2 diabetes. In contrast, CB1 antagonists and non-psychotropic phytocannabinoids like cannabidiol reduce these effects through interactions with both cannabinoid and non-cannabinoid receptors. These pharmacological approaches represent a source of new therapeutic agents for MetS. However, more studies are necessary to support the therapeutic potential of Cannabis and cannabinoids in metabolic abnormalities.
C1 [Ali Montoya-Alatriste, Claudia; Javier Alarcon-Aguilar, Francisco] Univ Autonoma Metropolitana Iztapalapa, Lab Farmacol, Dept Ciencias Salud, Div Ciencias Biol Salud, Ciudad De Mexico, Mexico.
C3 Universidad Autonoma Metropolitana - Mexico
RP Alarcon-Aguilar, FJ (corresponding author), Dept Ciencias Salud, Lab Farmacol, Div Ciencias Biol Salud, Linidad Iztapalapa, Av San Rafael Atlixco 186,Ap Postal 55-535, Cdmx 09340, Mexico.
EM aaasj2@prodigy.net.mx
FU National Council for Science and Technology (CONACYT) [17057];
   PRODEP-SEP
FX This study was supported by the National Council for Science and
   Technology (CONACYT) under Grant 17057 (CAMA) and PRODEP-SEP.
CR Abramovici H., CANNABIS MARIHUANA M
   Abrams DI, 2018, EUR J INTERN MED, V49, P7, DOI 10.1016/j.ejim.2018.01.003
   Aguilar S., 2018, INT DRUG POLICY CONS, P1
   Al-Zoubi R, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20081837
   Alshaarawy O, 2019, AM J MED, V132, P1327, DOI 10.1016/j.amjmed.2019.04.045
   Alshaarawy O, 2015, EPIDEMIOLOGY, V26, P597, DOI 10.1097/EDE.0000000000000314
   [Anonymous], 2006, DIABETES VOICE
   Argueta DA, 2017, PHYSIOL BEHAV, V171, P32, DOI 10.1016/j.physbeh.2016.12.044
   Atalay S, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9010021
   Auer R, 2018, ADDICTION, V113, P845, DOI 10.1111/add.14110
   Bian YM, 2019, ACTA PHARMACOL SIN, V40, P374, DOI 10.1038/s41401-018-0071-1
   Bielawiec P, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00114
   Bonini SA, 2018, J ETHNOPHARMACOL, V227, P300, DOI 10.1016/j.jep.2018.09.004
   Booth WT, 2019, MOLECULES, V24, DOI 10.3390/molecules24203672
   Borowska M, 2018, ENDOKRYNOL POL, V69, P705, DOI 10.5603/EP.a2018.0072
   Cassano T, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00124
   Chacin M, 2011, Sindrome Cardiometabolico, V1, P11
   Chang E, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0206152
   Chia CW, 2017, AM J PHYSIOL-ENDOC M, V313, pE359, DOI 10.1152/ajpendo.00080.2017
   Chorvat RJ, 2013, BIOORG MED CHEM LETT, V23, P4751, DOI 10.1016/j.bmcl.2013.06.066
   Cinar R, 2020, PHARMACOL THERAPEUT, V208, DOI 10.1016/j.pharmthera.2020.107477
   Di Marzo V, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081956
   Di Marzo V, 2011, HANDB EXP PHARMACOL, V203, P75, DOI 10.1007/978-3-642-17214-4_4
   Farokhnia M, 2020, TRANSL PSYCHIAT, V10, DOI 10.1038/s41398-020-0756-3
   Fellous T, 2020, BIOCHEM PHARMACOL, V175, DOI 10.1016/j.bcp.2020.113859
   Fernández-López D, 2013, BRAIN SCI, V3, P1043, DOI 10.3390/brainsci3031043
   FICF. Fundacio Institut Catala de Farmacologia, 2007, DARRERA REVISIO, V09, P57
   Finlay DB, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00359
   Fouda MA, 2020, BRIT J PHARMACOL, V177, P2932, DOI 10.1111/bph.15020
   Freeze J, 2018, PROCEEDINGS OF THE 51ST ANNUAL HAWAII INTERNATIONAL CONFERENCE ON SYSTEM SCIENCES (HICSS), P913
   Frisher M., 2010, Br J Diabetes Vasc Dis, V10, P267, DOI DOI 10.1177/1474651410385860
   González-Mariscal I, 2018, DIABETOLOGIA, V61, P1470, DOI 10.1007/s00125-018-4576-4
   González-Mariscal I, 2016, SCI REP-UK, V6, DOI 10.1038/srep33302
   González-Mariscal I, 2016, MOL CELL ENDOCRINOL, V423, P1, DOI 10.1016/j.mce.2015.12.015
   Gruden G, 2016, BRIT J PHARMACOL, V173, P1116, DOI 10.1111/bph.13226
   Guillamat-Prats R, 2019, THROMB HAEMOSTASIS, V119, P567, DOI 10.1055/s-0039-1678738
   Gutiérrez-Rodríguez A, 2018, GLIA, V66, P1417, DOI 10.1002/glia.23314
   Hirao-Suzuki M, 2020, J TOXICOL SCI, V45, P227, DOI 10.2131/jts.45.227
   Hirsch S, 2019, TOXINS, V11, DOI 10.3390/toxins11050275
   Horváth B, 2012, AM J PATHOL, V180, P432, DOI 10.1016/j.ajpath.2011.11.003
   Howlett AC, 2017, ADV PHARMACOL, V80, P169, DOI 10.1016/bs.apha.2017.03.007
   Hu Y, 2019, BIOSCIENCE REP, V39, DOI 10.1042/BSR20180650
   Iannotti FA, 2016, PROG LIPID RES, V62, P107, DOI 10.1016/j.plipres.2016.02.002
   Ignatowska-Jankowska B, 2011, NEUROSCI LETT, V490, P82, DOI 10.1016/j.neulet.2010.12.031
   Jadoon KA, 2016, DIABETES CARE, V39, P1777, DOI 10.2337/dc16-0650
   Kalla A, 2018, J CARDIOVASC MED, V19, P480, DOI 10.2459/JCM.0000000000000681
   Katchan V, 2016, AUTOIMMUN REV, V15, P513, DOI 10.1016/j.autrev.2016.02.008
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kuddus M, 2013, EMIR J FOOD AGR, V25, P736, DOI 10.9755/ejfa.v25i10.16400
   Laun AS, 2019, ACTA PHARMACOL SIN, V40, P300, DOI 10.1038/s41401-018-0031-9
   Lazzari P, 2011, BEHAV BRAIN RES, V217, P432, DOI 10.1016/j.bbr.2010.11.022
   León Oscar J., 2018, Rev. Colomb. Cardiol., V25, P230, DOI 10.1016/j.rccar.2017.11.030
   Li C, 2010, ISLETS, V2, P293, DOI 10.4161/isl.2.5.12729
   López ALL, 2018, ACTA ENDOCRINOL-BUCH, V14, P16, DOI 10.4183/aeb.2018.16
   Madras BK, 2015, 37 ECDD 2015 AGENDA
   Giménez VMM, 2018, THER ADV CARDIO DIS, V12, P177, DOI 10.1177/1753944718773690
   Martínez-Pinilla E, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00744
   Mastinu A, 2021, CURR MED CHEM, V28, P213, DOI 10.2174/0929867327666200210144847
   Mastinu A, 2018, HORM MOL BIOL CLIN I, V36, DOI 10.1515/hmbci-2018-0013
   Mastinu A, 2013, PHARMACOL RES, V74, P94, DOI 10.1016/j.phrs.2013.06.001
   McPartland JM, 2018, CANNABIS CANNABINOID, V3, P203, DOI 10.1089/can.2018.0039
   McPartland JM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0089566
   Meccariello R, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21031113
   Monnerie S, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-019-56909-7
   Muniyappa R, 2013, DIABETES CARE, V36, P2415, DOI 10.2337/dc12-2303
   Nahtigal IG, 2016, J Pain Manage, V9, P481
   Nava-Molina L, 2020, NUTR DIABETES, V10, DOI 10.1038/s41387-020-0110-0
   Newitt David, 2016, TCIA
   Ngueta G, 2020, ACTA DIABETOL, V57, P133, DOI 10.1007/s00592-019-01390-x
   Ngueta G, 2020, J DIABETES, V12, P38, DOI 10.1111/1753-0407.12958
   Nichols JM, 2020, CANNABIS CANNABINOID, V5, P12, DOI 10.1089/can.2018.0073
   Okafor CN, 2020, DRUG ALCOHOL DEPEN, V209, DOI 10.1016/j.drugalcdep.2020.107935
   Ong KKL, 2000, J PEDIATR ENDOCR MET, V13, P1419
   Oyagawa CRM, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01202
   Pazos RMR, 2017, THERAPEUTIC EFFECTS, P1
   Penner EA, 2013, AM J MED, V126, P583, DOI 10.1016/j.amjmed.2013.03.002
   Pepper I, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00311
   Pollastro F, 2018, NAT PROD COMMUN, V13, P1189
   Pudata V, 2011, J DIABETES METAB, V2, DOI 10.4172/2155-6156.1000163
   Radwan M.M., 2017, CANNABIS SATIVA L BO, P161, DOI [DOI 10.1007/978-3-319-54564-6_7, 10.1007/978-3-319-54564-67, DOI 10.1007/978-3-319-54564-67]
   Rajavashisth TB, 2012, BMJ OPEN, V2, DOI 10.1136/bmjopen-2011-000494
   Rajesh M, 2010, J AM COLL CARDIOL, V56, P2115, DOI 10.1016/j.jacc.2010.07.033
   Ramos AJA, 2000, MONOGRAPH CANNABIS, V12, P59
   Remiszewski P, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21041295
   Roberts CA, 2019, J PSYCHOPHARMACOL, V33, P1149, DOI 10.1177/0269881119862526
   Rock EM, 2013, BRIT J PHARMACOL, V170, P671, DOI 10.1111/bph.12322
   Ross JM, 2020, CANNABIS CANNABINOID, V5, P81, DOI 10.1089/can.2019.0091
   Scharf EL, 2017, CANNABIS CANNABINOID, V2, P259, DOI 10.1089/can.2017.0033
   Shin H, 2018, J CELL MOL MED, V22, P2337, DOI 10.1111/jcmm.13523
   Sidibeh CO, 2017, ENDOCRINE, V55, P839, DOI 10.1007/s12020-016-1172-6
   Simon V, 2017, EUR J ENDOCRINOL, V176, pR309, DOI 10.1530/EJE-16-1044
   Smeriglio A, 2018, FITOTERAPIA, V127, P101, DOI 10.1016/j.fitote.2018.02.002
   Stanley CP, 2013, EUR J PHARMACOL, V720, P376, DOI 10.1016/j.ejphar.2013.10.002
   Tam J, 2018, EUR J INTERN MED, V49, P23, DOI 10.1016/j.ejim.2018.01.009
   Tarragon E, 2018, CHEM SENSES, V43, P3, DOI 10.1093/chemse/bjx062
   Thompson CA, 2015, AM J MED, V128, pE23, DOI 10.1016/j.amjmed.2014.07.039
   Tibiriça E, 2010, DIABETOL METAB SYNDR, V2, DOI 10.1186/1758-5996-2-5
   Ukkola O, 2011, MOL CELL ENDOCRINOL, V340, P26, DOI 10.1016/j.mce.2011.02.009
   Valenzuela C, 2010, REV MED CHILE, V138, P621, DOI /S0034-98872010000500014
   van Eenige R, 2018, TRENDS ENDOCRIN MET, V29, P326, DOI 10.1016/j.tem.2018.03.001
   Vecera L, 2020, BRATISL MED J, V121, P79, DOI 10.4149/BLL_2020_012
   Vidot DC, 2016, AM J MED, V129, P173, DOI 10.1016/j.amjmed.2015.10.019
   Vilches-Flores A, 2013, CLIN SCI, V124, P467, DOI 10.1042/CS20120447
   Vong CT, 2019, BIOMED PHARMACOTHER, V111, P1176, DOI 10.1016/j.biopha.2018.12.126
   Zhang XY, 2016, CELL PHYSIOL BIOCHEM, V40, P1175, DOI 10.1159/000453171
   Zou SL, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19030833
NR 106
TC 5
Z9 5
U1 2
U2 8
PU UNIV SAO PAULO, CONJUNTO QUIMICAS
PI SAO PAULO
PA SERVICO PUBLICACOES E CIRCULACAO, CAIXA POSTAL 66083, SAO PAULO, 00000,
   BRAZIL
SN 1984-8250
EI 2175-9790
J9 BRAZ J PHARM SCI
JI Braz. J. Pharm. Sci.
PY 2022
VL 58
AR e20161
DI 10.1590/s2175-97902022e20161
PG 23
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 6E7RS
UT WOS:000883573800001
OA gold
DA 2025-06-11
ER

PT J
AU Mendez, L
   Dasilva, G
   Taltavull, NR
   Romeu, M
   Medina, I
AF Mendez, Lucia
   Dasilva, Gabriel
   Taltavull, Nuria
   Romeu, Marta
   Medina, Isabel
TI Marine Lipids on Cardiovascular Diseases and Other Chronic Diseases
   Induced by Diet: An Insight Provided by Proteomics and Lipidomics
SO MARINE DRUGS
LA English
DT Review
DE marine lipids; EPA; DHA; proteomics; lipidomics; metabolic syndrome;
   cardiovascular disease; type 2 diabetes
ID N-3 FATTY-ACID; FISH-OIL SUPPLEMENTATION; METABOLIC SYNDROME; OXIDATIVE
   STRESS; ADIPOSE-TISSUE; DOCOSAHEXAENOIC ACID; INSULIN-RESISTANCE;
   OMEGA-3 PUFAS; OMEGA-3-FATTY-ACID SUPPLEMENTATION; EICOSAPENTAENOIC ACID
AB Marine lipids, especially omega-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have largely been linked to prevention of diet-induced diseases. The anti-inflammatory and hypolipidemic properties of EPA and DHA supplementation have been well-described. However, there is still a significant lack of information about their particular mechanism of action. Furthermore, repeated meta-analyses have not shown conclusive results in support of their beneficial health effects. Modern "omics" approaches, namely proteomics and lipidomics, have made it possible to identify some of the mechanisms behind the benefits of marine lipids in the metabolic syndrome and related diseases, i.e., cardiovascular diseases and type 2 diabetes. Although until now their use has been scarce, these "omics" have brought new insights in this area of nutrition research. The purpose of the present review is to comprehensively show the research articles currently available in the literature which have specifically applied proteomics, lipidomics or both approaches to investigate the role of marine lipids intake in the prevention or palliation of these chronic pathologies related to diet. The methodology adopted, the class of marine lipids examined, the diet-related disease studied, and the main findings obtained in each investigation will be reviewed.
C1 [Mendez, Lucia; Dasilva, Gabriel; Medina, Isabel] Inst Invest Marinas IIM CSIC, Eduardo Cabello 6, E-36208 Vigo, Spain.
   [Taltavull, Nuria; Romeu, Marta] Univ Rovira & Virgili, Fac Med & Ciencies Salut, Unitat Farmacol, St Llorenc 21, E-43201 Reus, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Investigaciones Marinas (IIM); Universitat Rovira i Virgili
RP Mendez, L (corresponding author), Inst Invest Marinas IIM CSIC, Eduardo Cabello 6, E-36208 Vigo, Spain.
EM luciamendez@iim.csic.es; gabrielsilva@iim.csic.es;
   nuria.taltavull@urv.cat; marta.romeu@urv.cat; medina@iim.csic.es
RI ROMEU, MARTA/O-7129-2019; MEDINA, ISABEL/AAL-4012-2021; Mendez,
   Lucia/T-7016-2017; ROMEU, MARTA/A-8468-2014
OI Mendez, Lucia/0000-0002-9711-2994; MEDINA, ISABEL/0000-0002-1854-3359;
   ROMEU, MARTA/0000-0002-2131-1858
FU Spanish Ministry of Science and Innovation [AGL2013-49079-C2-1-R];
   Consejo Superior de Investigaciones Cientificas (CSIC); University of
   Santiago de Compostela (USC)
FX Spanish Ministry of Science and Innovation is acknowledged for grant
   AGL2013-49079-C2-1-R. The Consejo Superior de Investigaciones
   Cientificas (CSIC) and the University of Santiago de Compostela (USC)
   are gratefully acknowledged for the doctoral fellowship to G.D. Language
   revision by Hannelore Lott is appreciated.
CR Ahmed AA, 2014, NUTR METAB, V11, DOI 10.1186/1743-7075-11-6
   Ahmed N, 2005, J BIOL CHEM, V280, P5724, DOI 10.1074/jbc.M410973200
   Rangel-Zúñiga OA, 2015, BMC GENOMICS, V16, DOI 10.1186/s12864-015-1725-8
   Aukema HM, 2013, BRIT J NUTR, V110, P11, DOI 10.1017/S0007114512004606
   Bakker GCM, 2010, AM J CLIN NUTR, V91, P1044, DOI 10.3945/ajcn.2009.28822
   Balogun KA, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0082399
   Barden A, 2014, J LIPID RES, V55, P2401, DOI 10.1194/jlr.M045583
   Barden AE, 2015, AM J CLIN NUTR, V102, P1357, DOI 10.3945/ajcn.115.116384
   Bondia-Pons I, 2014, MOL NUTR FOOD RES, V58, P1873, DOI 10.1002/mnfr.201400155
   Bouwens M, 2009, AM J CLIN NUTR, V90, P415, DOI 10.3945/ajcn.2009.27680
   Burillo E, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-116
   Caesar R, 2016, J LIPID RES, V57, P474, DOI 10.1194/jlr.M065847
   Camargo A, 2013, J NUTR BIOCHEM, V24, P318, DOI 10.1016/j.jnutbio.2012.06.014
   Capel F, 2015, J NUTR BIOCHEM, V26, P949, DOI 10.1016/j.jnutbio.2015.04.003
   Cipollina C, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094836
   Cordain L, 2005, AM J CLIN NUTR, V81, P341, DOI 10.1093/ajcn.81.2.341
   Dasilva G, 2017, J NUTR BIOCHEM, V43, P53, DOI 10.1016/j.jnutbio.2017.02.007
   Dasilva G, 2016, FOOD CHEM, V205, P196, DOI 10.1016/j.foodchem.2016.03.020
   Dasilva G, 2015, J NUTR BIOCHEM, V26, P1385, DOI 10.1016/j.jnutbio.2015.07.007
   Davidson MH, 2006, AM J CARDIOL, V98, p27I, DOI 10.1016/j.amjcard.2005.12.024
   Dawczynski C, 2013, CLIN NUTR, V32, P686, DOI 10.1016/j.clnu.2012.12.010
   de Roos B, 2005, FASEB J, V19, P813, DOI 10.1096/fj.04-2974fje
   de Roos B, 2008, PROTEOMICS, V8, P1965, DOI 10.1002/pmic.200700457
   Filep JG, 2013, AM J PHYSIOL-CELL PH, V304, pC1127, DOI 10.1152/ajpcell.00063.2013
   Flachs P, 2011, DIABETOLOGIA, V54, P2626, DOI 10.1007/s00125-011-2233-2
   Ganesh V, 2012, BBA-PROTEINS PROTEOM, V1824, P1107, DOI 10.1016/j.bbapap.2012.06.006
   Gladine C, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0089393
   González-Périz A, 2006, FASEB J, V20, P2537, DOI 10.1096/fj.06-6250fje
   González-Périz A, 2009, FASEB J, V23, P1946, DOI 10.1096/fj.08-125674
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Hutcheson R, 2012, EXP DIABETES RES, DOI 10.1155/2012/271028
   Jimenez-Gomez Y, 2014, MOL NUTR FOOD RES, V58, P2177, DOI 10.1002/mnfr.201300901
   Johnson ML, 2015, AGING CELL, V14, P734, DOI 10.1111/acel.12352
   Joumard-Cubizolles L, 2013, EUR J LIPID SCI TECH, V115, P1492, DOI 10.1002/ejlt.201300310
   Kalish BT, 2013, AM J PHYSIOL-GASTR L, V305, pG818, DOI 10.1152/ajpgi.00106.2013
   Kalupahana NS, 2010, J NUTR, V140, P1915, DOI 10.3945/jn.110.125732
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Keelan JA, 2015, REPRODUCTION, V149, P171, DOI 10.1530/REP-14-0549
   Krammer J, 2011, INT J MED SCI, V8, P599, DOI 10.7150/ijms.8.599
   Kuda O, 2016, BIOCHEM BIOPH RES CO, V469, P731, DOI 10.1016/j.bbrc.2015.12.055
   Kussmann M, 2006, J BIOTECHNOL, V124, P758, DOI 10.1016/j.jbiotec.2006.02.014
   Lankinen M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0022646
   Lankinen M, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005258
   Lopez EF, 2015, AM J PHYSIOL-HEART C, V308, pH269, DOI 10.1152/ajpheart.00604.2014
   Mas E, 2016, CLIN NUTR, V35, P331, DOI 10.1016/j.clnu.2015.04.004
   Mas E, 2012, CLIN CHEM, V58, P1476, DOI 10.1373/clinchem.2012.190199
   Mavrommatis Y, 2010, BRIT J NUTR, V103, P16, DOI 10.1017/S0007114509991450
   McDaniel JC, 2011, WOUND REPAIR REGEN, V19, P189, DOI 10.1111/j.1524-475X.2010.00659.x
   Méndez L, 2017, J NUTR BIOCHEM, V41, P84, DOI 10.1016/j.jnutbio.2016.12.005
   Méndez L, 2013, FREE RADICAL BIO MED, V55, P8, DOI 10.1016/j.freeradbiomed.2012.11.004
   Midtbo LK, 2015, J NUTR BIOCHEM, V26, P585, DOI 10.1016/j.jnutbio.2014.12.005
   Moore JB, 2011, ADV NUTR, V2, P355, DOI 10.3945/an.111.000554
   Murakami M, 2011, EXP ANIM TOKYO, V60, P7, DOI 10.1538/expanim.60.7
   Nording ML, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076575
   Ottestad I, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0042550
   Padro T, 2015, J LIPID RES, V56, P1043, DOI 10.1194/jlr.P052217
   Pellis L, 2012, METABOLOMICS, V8, P347, DOI 10.1007/s11306-011-0320-5
   Polus A, 2016, BBA-MOL CELL BIOL L, V1861, P1746, DOI 10.1016/j.bbalip.2016.08.005
   Polus A, 2015, BBA-MOL CELL BIOL L, V1851, P1146, DOI 10.1016/j.bbalip.2015.05.002
   Poulsen RC, 2008, AM J HEMATOL, V83, P437, DOI 10.1002/ajh.21170
   Richard D, 2008, PHARMACOL RES, V57, P451, DOI 10.1016/j.phrs.2008.05.002
   Rudkowska I, 2013, J NUTR BIOCHEM, V24, P54, DOI 10.1016/j.jnutbio.2012.01.016
   Ruskovska T, 2013, J PROTEOMICS, V92, P323, DOI 10.1016/j.jprot.2013.04.002
   Sauer S, 2015, PROTEOMICS, V15, P997, DOI 10.1002/pmic.201400383
   Schuchardt JP, 2014, PROSTAG LEUKOTR ESS, V90, P27, DOI 10.1016/j.plefa.2013.12.008
   Sears B., 2005, THE ANTI INFLAMMATIO
   Shearer GC, 2010, J LIPID RES, V51, P2074, DOI 10.1194/M900193-JLR200
   Simopoulos AP, 1999, AM J CLIN NUTR, V70, p560S, DOI 10.1093/ajcn/70.3.560s
   Skorve J, 2015, LIPIDS HEALTH DIS, V14, DOI 10.1186/s12944-015-0086-2
   SMITH PK, 1985, ANAL BIOCHEM, V150, P76, DOI 10.1016/0003-2697(85)90442-7
   Taltavull N, 2016, FOOD FUNCT, V7, P3981, DOI [10.1039/C6FO00589F, 10.1039/c6fo00589f]
   Ting HC, 2015, J NUTR BIOCHEM, V26, P769, DOI 10.1016/j.jnutbio.2015.02.005
   Tyers M, 2003, NATURE, V422, P193, DOI 10.1038/nature01510
   Warensjö E, 2005, DIABETOLOGIA, V48, P1999, DOI 10.1007/s00125-005-1897-x
   WASINGER VC, 1995, ELECTROPHORESIS, V16, P1090, DOI 10.1002/elps.11501601185
   Wenk MR, 2005, NAT REV DRUG DISCOV, V4, P594, DOI 10.1038/nrd1776
   WHO Organization, THE TOP 10 CAUSES OF
   Wilkins M., 1997, PROTEOME RES NEW FRO, P35
   Wrzesinski K, 2013, J PROTEOMICS, V84, P61, DOI 10.1016/j.jprot.2013.03.027
   Wu C, 2015, CIRC-HEART FAIL, V8, P1077, DOI 10.1161/CIRCHEARTFAILURE.115.002073
   Wymann MP, 2008, NAT REV MOL CELL BIO, V9, P162, DOI 10.1038/nrm2335
NR 81
TC 17
Z9 19
U1 3
U2 28
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1660-3397
J9 MAR DRUGS
JI Mar. Drugs
PD AUG
PY 2017
VL 15
IS 8
AR 258
DI 10.3390/md15080258
PG 29
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FF2YT
UT WOS:000408763400023
PM 28820493
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Oliveira, PS
   Chaves, VC
   Bona, NP
   Soares, MSP
   Cardoso, JD
   Vasconcellos, FA
   Tavares, RG
   Vizzotto, M
   da Silva, LMC
   Grecco, FB
   Gamaro, GD
   Spanevello, RM
   Lencina, CL
   Reginatto, FH
   Stefanello, FM
AF Oliveira, Pathise Souto
   Chaves, Vitor Clasen
   Bona, Natalia Pontes
   Pereira Soares, Mayara Sandrielly
   Cardoso, Juliane de Souza
   Vasconcellos, Flavia Aleixo
   Tavares, Rejane Giacomelli
   Vizzotto, Marcia
   Cerqueira da Silva, Luisa Mariano
   Grecco, Fabiane Borelli
   Gamaro, Giovana Duzzo
   Spanevello, Roselia Maria
   Lencina, Claiton Leoneti
   Reginatto, Flavio Henrique
   Stefanello, Francieli Moro
TI Eugenia uniflora fruit (red type) standardized extract: a
   potential pharmacological tool to diet-induced metabolic syndrome damage
   management
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Metabolic syndrome; Eugenia uniflora; Phenolic compounds;
   Pharmacological management
ID OXIDATIVE STRESS; ANTIINFLAMMATORY PROPERTIES; INSULIN-RESISTANCE;
   RAT-BRAIN; ACETYLCHOLINESTERASE; HIPPOCAMPUS; POLYPHENOLS; EXPRESSION;
   LEAVES; MODEL
AB The aim of this study was to investigate the effect of Eugenia uniflora fruit (red type) extract on metabolic status, as well as on neurochemical and behavioral parameters in an animal model of metabolic syndrome induced by a highly palatable diet (HPD). Rats were treated for 150 days and divided into 4 experimental groups: standard chow (SC) and water orally, SC and E. uniflora extract (200 mg/kg daily, p. o), HPD and water orally, HPD and extract. Our data showed that HPD caused glucose intolerance, increased visceral fat, weight gain, as well as serum glucose, triacylglycerol, total cholesterol and LDL cholesterol; however, E. uniflora prevented these alterations. The extract decreased lipid peroxidation and prevented the reduction of superoxide dismutase and catalase activities in the prefrontal cortex, hippocampus and striatum of animals submitted to HPD. We observed a HPD-induced reduction of thiol content in these cerebral structures. The extract prevented increased acetylcholinesterase activity in the prefrontal cortex caused by HPD and the increase in immobility time observed in the forced swim test. Regarding chemical composition, LC/MS analysis showed the presence of nine anthocyanins as the major compounds. In conclusion, E. uniflora extract showed benefits against metabolic alterations caused by HPD, as well as exhibited antioxidant and antidepressant-like effects. (C) 2017 Published by Elsevier Masson SAS.
C1 [Oliveira, Pathise Souto; Bona, Natalia Pontes; Cardoso, Juliane de Souza; Tavares, Rejane Giacomelli; Lencina, Claiton Leoneti; Stefanello, Francieli Moro] Univ Fed Pelotas, Ctr Ciencias Quim Farmaceut & Alimentos, Lab Biomarcadores, Campus Univ S-N, Pelotas, RS, Brazil.
   [Chaves, Vitor Clasen; Reginatto, Flavio Henrique] Univ Fed Santa Catarina, Programa Posgrad Biotecnol & Biociencias, Lab Farmacognosia, Florianopolis, SC, Brazil.
   [Pereira Soares, Mayara Sandrielly; Gamaro, Giovana Duzzo; Spanevello, Roselia Maria] Univ Fed Pelotas, Ctr Ciencias Quim Farmaceut & Alimentos, Lab Neuroquim Inflamacao & Canc, Campus Univ S-N, Pelotas, RS, Brazil.
   [Vasconcellos, Flavia Aleixo] Univ Fed Pelotas, Ctr Ciencias Quim Farmaceut & Alimentos, Lab Quim Aplicada Bioat, Campus Univ S-N, Pelotas, RS, Brazil.
   [Vizzotto, Marcia] Empresa Brasileira Pesquisa Agr, Ctr Pesquisa Agr Clima Temp, Pelotas, RS, Brazil.
   [Cerqueira da Silva, Luisa Mariano; Grecco, Fabiane Borelli] Univ Fed Pelotas, Programa Posgrad Vet, Lab Patol Anim, Campus Univ S-N, Pelotas, RS, Brazil.
C3 Universidade Federal de Pelotas; Universidade Federal de Santa Catarina
   (UFSC); Universidade Federal de Pelotas; Universidade Federal de
   Pelotas; Empresa Brasileira de Pesquisa Agropecuaria (EMBRAPA);
   Universidade Federal de Pelotas
RP Stefanello, FM (corresponding author), Univ Fed Pelotas, Campus Univ S-N, BR-96160000 Capao Do Leao, RS, Brazil.; Reginatto, FH (corresponding author), Univ Fed Santa Catarina, Florianopolis, SC, Brazil.
EM flavio.reginatto@ufsc.br; francieli.stefanelo@ufpel.edu.br
RI Vasconcellos, F/E-4773-2016; Oliveira, Ronaldo/X-1597-2019; Spanevello,
   Roselia/H-1610-2018; Tavares, Rejane/C-1307-2010; Gamaro,
   Giovana/G-8868-2018
OI Gamaro, Giovana/0000-0002-1674-1693; Giacomelli Tavares,
   Rejane/0000-0002-9806-1893; VIERA OLIVEIRA,
   PATRICIA/0000-0003-2155-6262; REGINATTO, FLAVIO/0000-0002-4710-8540;
   Cardoso, Juliane/0000-0002-2726-4159; Spanevello,
   Roselia/0000-0002-5117-2000
FU FAPERGS; CAPES; CNPq
FX The Brazilian research funding agencies FAPERGS, CAPES and CNPq
   supported this study. The authors thank Hedy Hofmann for the English
   review.
CR AEBI H, 1984, METHOD ENZYMOL, V105, P121
   Aksenov MY, 2001, NEUROSCI LETT, V302, P141, DOI 10.1016/S0304-3940(01)01636-6
   Amiot MJ, 2016, OBES REV, V17, P573, DOI 10.1111/obr.12409
   [Anonymous], 2002, SCI AGR
   Aschbacher K, 2014, PSYCHONEUROENDOCRINO, V46, P14, DOI 10.1016/j.psyneuen.2014.04.003
   Bagul PK, 2012, PHARMACOL RES, V66, P260, DOI 10.1016/j.phrs.2012.05.003
   Boonloh K, 2015, NUTRIENTS, V7, P6313, DOI 10.3390/nu7085292
   Bordignon CL, 2009, CIENCIA TECNOL ALIME, V29, P183, DOI 10.1590/S0101-20612009000100028
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Costa AGV, 2013, J FUNCT FOODS, V5, P539, DOI 10.1016/j.jff.2013.01.029
   Einbond LS, 2004, FOOD CHEM, V84, P23, DOI 10.1016/S0308-8146(03)00162-6
   ELLMAN GL, 1961, BIOCHEM PHARMACOL, V7, P88, DOI 10.1016/0006-2952(61)90145-9
   Gammone MA, 2015, FOOD NUTR RES, V59, DOI 10.3402/fnr.v59.26762
   Schumacher NSG, 2015, ANTIOXIDANTS-BASEL, V4, P662, DOI 10.3390/antiox4040662
   Gupta N, 2012, ENDOCR REV, V33, P48, DOI 10.1210/er.2010-0028
   Hanhineva K, 2010, INT J MOL SCI, V11, P1365, DOI 10.3390/ijms11041365
   Hsu CL, 2007, BRIT J NUTR, V98, P727, DOI 10.1017/S000711450774686X
   Huynh TN, 2011, BEHAV BRAIN RES, V222, P212, DOI 10.1016/j.bbr.2011.03.038
   Kade IJ, 2008, EXP TOXICOL PATHOL, V60, P365, DOI 10.1016/j.etp.2007.12.001
   Kaster MP, 2007, PROG NEURO-PSYCHOPH, V31, P690, DOI 10.1016/j.pnpbp.2006.12.018
   Kaster MP, 2004, NEUROSCI LETT, V355, P21, DOI 10.1016/j.neulet.2003.10.040
   Kuhad A, 2008, LIFE SCI, V83, P128, DOI 10.1016/j.lfs.2008.05.013
   Lee J, 2005, J AOAC INT, V88, P1269
   Liu S, 2016, BEHAV BRAIN RES, V302, P191, DOI 10.1016/j.bbr.2016.01.037
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   Lozano I, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0074-1
   Madani Z, 2015, BIOMED REP, V3, P731, DOI 10.3892/br.2015.498
   Manzano S, 2010, MOL NUTR FOOD RES, V54, P1773, DOI 10.1002/mnfr.201000019
   Martinez-Correa HA, 2011, J SUPERCRIT FLUID, V55, P998, DOI 10.1016/j.supflu.2010.09.001
   Miliauskas G, 2004, FOOD CHEM, V85, P231, DOI 10.1016/j.foodchem.2003.05.007
   MISRA HP, 1972, J BIOL CHEM, V247, P3170
   Mopuri R, 2015, BMC COMPLEM ALTERN M, V15, DOI 10.1186/s12906-015-0598-3
   Morley JE, 2010, J ALZHEIMERS DIS, V20, P737, DOI 10.3233/JAD-2010-091576
   Murdolo G, 2013, FREE RADICAL BIO MED, V65, P811, DOI 10.1016/j.freeradbiomed.2013.08.007
   Nizri E, 2006, NEUROPHARMACOLOGY, V50, P540, DOI 10.1016/j.neuropharm.2005.10.013
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   Oliveira PS, 2017, BIOMED PHARMACOTHER, V88, P939, DOI 10.1016/j.biopha.2017.01.121
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   da Silva LMR, 2014, FOOD CHEM, V143, P398, DOI 10.1016/j.foodchem.2013.08.001
   Senaphan K, 2015, NUTRIENTS, V7, P6446, DOI 10.3390/nu7085283
   Singleton VL, 1999, METHOD ENZYMOL, V299, P152
   Soares D. J., 2015, PLOS ONE, V10, P1
   Souza CG, 2007, LIFE SCI, V81, P198, DOI 10.1016/j.lfs.2007.05.001
   Treviño S, 2015, SYNAPSE, V69, P421, DOI 10.1002/syn.21832
   Tsuda T, 2008, J AGR FOOD CHEM, V56, P642, DOI 10.1021/jf073113b
   Victoria FN, 2013, NEUROSCI LETT, V544, P105, DOI 10.1016/j.neulet.2013.03.054
   Zarros A, 2009, METAB BRAIN DIS, V24, P337, DOI 10.1007/s11011-009-9133-x
NR 47
TC 28
Z9 29
U1 1
U2 25
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD AUG
PY 2017
VL 92
BP 935
EP 941
DI 10.1016/j.biopha.2017.05.131
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA FE0MY
UT WOS:000407915600105
PM 28618655
OA Green Published
DA 2025-06-11
ER

PT J
AU Won, JC
   Park, CY
   Oh, SW
   Lee, ES
   Youn, BS
   Kim, MS
AF Won, Jong Chul
   Park, Cheol-Young
   Oh, Sang Woo
   Lee, Eon Sook
   Youn, Byung-Soo
   Kim, Min-Seon
TI Plasma Clusterin (ApoJ) Levels Are Associated with Adiposity and
   Systemic Inflammation
SO PLOS ONE
LA English
DT Article
ID CORONARY-HEART-DISEASE; GENOME-WIDE ASSOCIATION; C-REACTIVE PROTEIN;
   APOLIPOPROTEIN-J; INSULIN-RESISTANCE; ALZHEIMERS-DISEASE;
   CLUSTERIN/APOLIPOPROTEIN-J; IDENTIFIES VARIANTS; METABOLIC SYNDROME;
   OXIDATIVE STRESS
AB Obesity and insulin resistance are hallmarks of the metabolic syndrome, which is associated with low-grade chronic inflammation. Clusterin/apolipoprotein J is an abundant plasma chaperone protein that has recently been suggested as a potential biomarker that reflects the inflammatory process in Alzheimer's disease. In the present study, we investigated anthropometric and clinical factors affecting the plasma levels of clusterin in healthy Korean subjects. We measured fasting plasma clusterin levels in healthy Korean adults (111 men and 93 women) using ELISA kit. We analyzed the relationship between plasma clusterin concentrations and anthropometric and clinical parameters. Fasting plasma clusterin concentrations were higher in overweight and obese subjects than in lean subjects. Correlation analysis revealed that the plasma clusterin levels were positively associated with indices of obesity such as body mass index (BMI), waist circumference and waist-hip ratio and markers of systemic inflammation such as high sensitivity C-reactive protein (hsCRP), uric acid, ferritin and retinol binding protein-4. Multiple linear regression analysis showed that sex, BMI and hsCRP were independent determinants of plasma clusterin levels. Furthermore, plasma clusterin levels showed an upward trend with increasing numbers of metabolic syndrome components. These findings suggest that fasting plasma clusterin levels correlate with the parameters of adiposity and systemic inflammation in healthy adults. Therefore, the circulating clusterin level may be a surrogate marker for obesity-associated systemic inflammation.
C1 [Won, Jong Chul] Inje Univ, Sanggye Paik Hosp, Coll Med, Dept Internal Med,Cardiovasc & Metab Dis Ctr, Seoul, South Korea.
   [Park, Cheol-Young] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Sch Med, Dept Internal Med, Seoul, South Korea.
   [Oh, Sang Woo] Dongguk Univ, Ilsan Hosp, Dept Family Med, Ilsan, South Korea.
   [Lee, Eon Sook] Inje Univ, Ilsan Paik Hosp, Coll Med, Dept Family Med,Ctr Hlth Promot, Ilsan, South Korea.
   [Youn, Byung-Soo] Wonkang Univ, Sch Med, Dept Anat, Iksan, Jeonbuk, South Korea.
   [Kim, Min-Seon] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Internal Med, Seoul, South Korea.
C3 Inje University; Sungkyunkwan University (SKKU); Samsung Medical Center;
   NHIS Ilsan Hospital; Dongguk University; Inje University; Wonkwang
   University; University of Ulsan; Asan Medical Center
RP Youn, BS (corresponding author), Wonkang Univ, Sch Med, Dept Anat, Iksan, Jeonbuk, South Korea.
EM byung4jc@gmail.com; mskim@amc.seoul.kr
RI Park, Cheol-Young/C-6690-2018
OI Park, Cheol-Young/0000-0002-9415-9965; Lee, Eon
   Sook/0000-0002-6148-2512; Won, Jong Chul/0000-0002-2219-4083; Oh, Sang
   Woo/0000-0002-5623-6720
FU National Research Foundation of Korea [2013M3C7A1056024]; Asan Institute
   for Life Science [11similar to326]; Priority Research Centers Program
   through the National Research Foundation of Korea (NRF) - Ministry of
   Education, Science and Technology [2010-0020224]
FX This study was supported by grants from the National Research Foundation
   of Korea (2013M3C7A1056024), and the Asan Institute for Life Science (11
   similar to 326). This study was also supported by a Priority Research
   Centers Program through the National Research Foundation of Korea (NRF)
   funded by the Ministry of Education, Science and Technology
   (2010-0020224). The funders had no role in study design, data collection
   and analysis, decision to publish, or preparation of the manuscript.
CR Albert MA, 2003, CIRCULATION, V108, P161, DOI 10.1161/01.CIR.0000080289.72166.CF
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   [Anonymous], AS PAC PERSP RED OB
   Arnold T, 2011, PEDIATR RES, V69, P237, DOI 10.1203/PDR.0b013e31820930cb
   Bhamra MS, 2012, ELECTROPHORESIS, V33, P3598, DOI 10.1002/elps.201200161
   BURKEY BF, 1992, J LIPID RES, V33, P1517
   CHOIMIURA NH, 1992, J BIOCHEM, V112, P557, DOI 10.1093/oxfordjournals.jbchem.a123938
   Craft S, 2012, NAT REV NEUROL, V8, P360, DOI 10.1038/nrneurol.2012.112
   Falgarone G, 2009, ADV CANCER RES, V104, P139, DOI 10.1016/S0065-230X(09)04008-1
   Fernández-Real JM, 1998, DIABETES CARE, V21, P62, DOI 10.2337/diacare.21.1.62
   Fukushima M, 1999, DIABETES CARE, V22, P1911, DOI 10.2337/diacare.22.11.1911
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   HARDARDOTTIR I, 1994, J CLIN INVEST, V94, P1304, DOI 10.1172/JCI117449
   Harold D, 2009, NAT GENET, V41, P1088, DOI 10.1038/ng.440
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Ishii T, 2001, ATHEROSCLEROSIS, V158, P215, DOI 10.1016/S0021-9150(01)00416-6
   JENNE DE, 1991, J BIOL CHEM, V266, P11030
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   KELSO GJ, 1994, BIOCHEMISTRY-US, V33, P832, DOI 10.1021/bi00169a026
   Kim HJ, 2009, ARTERIOSCL THROM VAS, V29, P1558, DOI 10.1161/ATVBAHA.109.190058
   Kujiraoka T, 2006, J ATHEROSCLER THROMB, V13, P314, DOI 10.5551/jat.13.314
   Lambert JC, 2009, NAT GENET, V41, P1094, DOI 10.1038/ng.439
   Lumeng CN, 2011, J CLIN INVEST, V121, P2111, DOI 10.1172/JCI57132
   Meisinger C, 2008, ARTERIOSCL THROM VAS, V28, P1186, DOI 10.1161/ATVBAHA.107.160184
   Navab M, 1997, J CLIN INVEST, V99, P2005, DOI 10.1172/JCI119369
   Profenno LA, 2010, BIOL PSYCHIAT, V67, P505, DOI 10.1016/j.biopsych.2009.02.013
   Rajala MW, 2003, ENDOCRINOLOGY, V144, P3765, DOI 10.1210/en.2003-0580
   Ronti T, 2006, CLIN ENDOCRINOL, V64, P355, DOI 10.1111/j.1365-2265.2006.02474.x
   ROSENBERG ME, 1995, INT J BIOCHEM CELL B, V27, P633, DOI 10.1016/1357-2725(95)00027-M
   Shapiro H, 2011, THESCIENTIFICWORLDJO, V11, P2509, DOI 10.1100/2011/397971
   Shirasawa T, 2009, J ATHEROSCLER THROMB, V16, P772
   Tamakoshi K, 2003, INT J OBESITY, V27, P443, DOI 10.1038/sj.ijo.0802260
   Thambisetty M, 2010, ARCH GEN PSYCHIAT, V67, P739, DOI 10.1001/archgenpsychiatry.2010.78
   Trougakos IP, 2006, FREE RADICAL RES, V40, P1324, DOI 10.1080/10715760600902310
   Trougakos IP, 2002, EXP GERONTOL, V37, P1175, DOI 10.1016/S0531-5565(02)00139-0
   Yao-Borengasser A, 2007, J CLIN ENDOCR METAB, V92, P2590, DOI 10.1210/jc.2006-0816
   Yu JT, 2013, NEUROBIOL AGING, V34, p[1921, e1917]
NR 37
TC 73
Z9 77
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 30
PY 2014
VL 9
IS 7
AR e103351
DI 10.1371/journal.pone.0103351
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AM7EZ
UT WOS:000340028800040
PM 25076422
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Leisegang, K
   Udodong, A
   Bouic, PJD
   Henkel, RR
AF Leisegang, K.
   Udodong, A.
   Bouic, P. J. D.
   Henkel, R. R.
TI Effect of the metabolic syndrome on male reproductive function: a
   case-controlled pilot study
SO ANDROLOGIA
LA English
DT Article
DE male infertility; metabolic syndrome; obesity; progesterone;
   testosterone
ID BODY-MASS INDEX; SEMEN QUALITY; SPERM FUNCTION; MALE OBESITY;
   MALE-INFERTILITY; TNF-ALPHA; MEN; TESTOSTERONE; HORMONES; IMPACT
AB The metabolic syndrome (MetS) is a constellation of various risk factors. This study aimed to investigate the effect of MetS on testosterone and progesterone, and semen parameters, in a case-controlled pilot study. Male patients (n=54) had body mass index, waist-to-hip ratio (WHR) and blood pressure recorded. Blood was analysed for HDL cholesterol, triglycerides and glucose. Saliva was assayed for free testosterone and free progesterone. Ejaculates were analysed for volume, sperm concentration, total sperm count, motility, vitality, mitochondrial membrane potential (MMP), DNA fragmentation and leucocyte concentration. Participants were divided into the control group (n=28) and the MetS group (n=26). Differences were found between the groups for body mass index, WHR, blood pressure, high-density lipoprotein (HDL), triglycerides and glucose. The MetS group showed significant reductions in sperm concentration (P=0.0026), total sperm count (P=0.0034), total motility (P=0.0291), sperm vitality (P=0.002), MMP (P=0.0039), free testosterone (P=0.0093) and free progesterone (P=0.0130), while values for DNA fragmentation increased (P=0.0287). Results indicate that patients with MetS have compromised sperm parameters in the absence of leucocytospermia. A reduction in free progesterone suggests that steroidogenesis cascades may be compromised. It is hypothesised that a systemic pro-inflammatory state with oxidative stress associated with MetS may provide a novel explanation.
C1 [Leisegang, K.; Udodong, A.; Henkel, R. R.] Univ Western Cape, Dept Med Biosci, ZA-7535 Bellville, South Africa.
   [Leisegang, K.] Univ Western Cape, Sch Nat Med, ZA-7535 Bellville, South Africa.
   [Bouic, P. J. D.] Univ Stellenbosch, Div Med Microbiol, Dept Pathol, ZA-7505 Tygerberg, South Africa.
   [Bouic, P. J. D.] Tygerberg Acad Hosp, Tygerberg, South Africa.
C3 University of the Western Cape; University of the Western Cape;
   Stellenbosch University
RP Henkel, RR (corresponding author), Univ Western Cape, Dept Med Biosci, Private Bag X17, ZA-7535 Bellville, South Africa.
EM rhenkel@uwc.ac.za
RI Leisegang, Kristian/AAS-3925-2021
OI Leisegang, Kristian/0000-0002-3003-8048; Henkel,
   Ralf/0000-0003-1128-2982
FU South African Medical Research Council, Parow, South Africa
FX The authors wish to thank the South African Medical Research Council,
   Parow, South Africa, for funding this study.
CR Aggerholm AS, 2008, FERTIL STERIL, V90, P619, DOI 10.1016/j.fertnstert.2007.07.1292
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Guazzone VA, 2009, MICROSC RES TECHNIQ, V72, P620, DOI 10.1002/jemt.20704
   Bialas M, 2009, AM J REPROD IMMUNOL, V62, P51, DOI 10.1111/j.1600-0897.2009.00711.x
   Blanchette S, 2006, HORM METAB RES, V38, P330, DOI 10.1055/s-2006-925392
   Boyanov M A, 2003, Aging Male, V6, P1
   Chavarro JE, 2010, FERTIL STERIL, V93, P2222, DOI 10.1016/j.fertnstert.2009.01.100
   Dousset B, 1997, HUM REPROD, V12, P1476, DOI 10.1093/humrep/12.7.1476
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Fejes I, 2006, ARCH ANDROLOGY, V52, P97, DOI 10.1080/01485010500315479
   Fejes I, 2005, ANDROLOGIA, V37, P155, DOI 10.1111/j.1439-0272.2005.00671.x
   Feldman HA, 2002, J CLIN ENDOCR METAB, V87, P589, DOI 10.1210/jc.87.2.589
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Guay AT, 2009, J ANDROL, V30, P370, DOI 10.2164/jandrol.108.006015
   Håkonsen LB, 2011, REPROD HEALTH, V8, DOI 10.1186/1742-4755-8-24
   Hales DB, 2005, ANN NY ACAD SCI, V1061, P120, DOI 10.1196/annals.1336.014
   Hammoud AO, 2008, FERTIL STERIL, V90, P897, DOI 10.1016/j.fertnstert.2008.08.026
   Henkel R, 2005, ANDROLOGIA, V37, P205, DOI 10.1111/j.1439-0272.2005.00699.x
   Henkel R, 2012, ANDROLOGIA, V44, P287, DOI 10.1111/j.1439-0272.2011.01179.x
   Henkel R, 2004, FERTIL STERIL, V81, P965, DOI 10.1016/j.fertnstert.2003.09.044
   Hofny ERM, 2010, FERTIL STERIL, V94, P581, DOI 10.1016/j.fertnstert.2009.03.085
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Isidori AM, 1999, J CLIN ENDOCR METAB, V84, P3673, DOI 10.1210/jc.84.10.3673
   Jensen TK, 2004, FERTIL STERIL, V82, P863, DOI 10.1016/j.fertnstert.2004.03.056
   Kasturi SS, 2008, J ANDROL, V29, P251, DOI 10.2164/jandrol.107.003731
   Kort HI, 2006, J ANDROL, V27, P450, DOI 10.2164/jandrol.05124
   Kupelian V, 2006, J CLIN ENDOCR METAB, V91, P843, DOI 10.1210/jc.2005-1326
   La Vignera S, 2012, J ANDROL, V33, P145, DOI 10.2164/jandrol.111.013193
   Lampiao F, 2008, REPROD BIOMED ONLINE, V17, P628, DOI 10.1016/S1472-6483(10)60309-4
   MacDonald AA, 2010, HUM REPROD UPDATE, V16, P293, DOI 10.1093/humupd/dmp047
   Mallidis C, 2009, INT J ANDROL, V32, P295, DOI 10.1111/j.1365-2605.2007.00849.x
   Mallidis C, 2011, REPRODUCTION, V142, P63, DOI 10.1530/REP-10-0472
   Martinez R, 2007, ASIAN J ANDROL, V9, P102
   Midzak AS, 2009, MOL CELL ENDOCRINOL, V299, P23, DOI 10.1016/j.mce.2008.07.016
   Morales A, 2000, J UROLOGY, V163, P705, DOI 10.1016/S0022-5347(05)67788-9
   Morales A, 2002, EUR UROL, V41, P113, DOI 10.1016/S0302-2838(01)00039-2
   Oettel M, 2004, Aging Male, V7, P236
   Palmer NO, 2012, AM J PHYSIOL-ENDOC M, V302, pE768, DOI 10.1152/ajpendo.00401.2011
   Pauli EM, 2008, FERTIL STERIL, V90, P346, DOI 10.1016/j.fertnstert.2007.06.046
   PAYNE AH, 1995, BIOL REPROD, V52, P217, DOI 10.1095/biolreprod52.2.217
   Politch JA, 2007, HUM REPROD, V22, P2928, DOI 10.1093/humrep/dem281
   QUINN P, 1985, FERTIL STERIL, V44, P493
   Ramirez-Torres M A, 2000, Ginecol Obstet Mex, V68, P224
   Rybar R, 2011, ANDROLOGIA, V43, P286, DOI 10.1111/j.1439-0272.2010.01057.x
   Saad F, 2009, J STEROID BIOCHEM, V114, P40, DOI 10.1016/j.jsbmb.2008.12.022
   Sermondade N, 2012, ARCH INTERN MED, V172, P440, DOI 10.1001/archinternmed.2011.1382
   Shalaby MA, 2004, PHARMACOL RES, V50, P137, DOI 10.1016/j.phrs.2003.10.013
   Sherbet DP, 2003, J BIOL CHEM, V278, P48563, DOI 10.1074/jbc.M307586200
   Stewart TM, 2009, HUM REPROD, V24, P1561, DOI 10.1093/humrep/dep075
   Tamakoshi K, 2003, INT J OBESITY, V27, P443, DOI 10.1038/sj.ijo.0802260
   Taslim S, 2009, ANN ACAD MED SINGAP, V38, P29
   Tronchon V, 2008, HUM REPROD, V23, P2858, DOI 10.1093/humrep/den277
   Vartanian V, 2006, P NATL ACAD SCI USA, V103, P1864, DOI 10.1073/pnas.0507444103
   World Health Organization (WHO), 2010, LAB MAN EX PROC HUM, DOI WHO Press
   Yao PL, 2009, BIOL REPROD, V80, P581, DOI 10.1095/biolreprod.108.073122
   Yasuda M, 2008, J MENS HEALTH, V5, P56, DOI 10.1016/j.jomh.2007.12.004
NR 57
TC 49
Z9 50
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-4569
EI 1439-0272
J9 ANDROLOGIA
JI Andrologia
PD MAR
PY 2014
VL 46
IS 2
BP 167
EP 176
DI 10.1111/and.12060
PG 10
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AA7KH
UT WOS:000331275800014
PM 23278477
OA gold
DA 2025-06-11
ER

PT J
AU Higuchi, Y
   Maeda, T
   Guan, JZ
   Oyama, J
   Sugano, M
   Makino, N
AF Higuchi, Yoshihiro
   Maeda, Toyoki
   Guan, Jing-Zhi
   Oyama, Junichi
   Sugano, Masahiro
   Makino, Naoki
TI Diagonal Earlobe Crease are Associated With Shorter Telomere in Male
   Japanese Patients With Metabolic Syndrome-A Pilot Study-
SO CIRCULATION JOURNAL
LA English
DT Article
DE Aging; Atherosclerosis; Earlobe crease; Metabolic syndrome; Telomere
   length
ID CORONARY-ARTERY-DISEASE; EAR-LOBE CREASE; OXIDATIVE STRESS; LENGTH;
   RISK; ATHEROSCLEROSIS; SIGN; STIFFNESS; BIOLOGY; MARKER
AB Background Diagonal earlobe crease (ELC) have been proposed as a marker of generalized atherosclerosis, so in the present study it was investigated whether individuals with ELC have a shortened telomere, which correlates with an accelerated cell turnover and premature aging, leading to atherosclerosis.
   Methods and Results The mean terminal restriction fragment (TRF) was determined by Southern blot hybridization in the peripheral blood cells of 34 male Japanese patients with metabolic syndrome (MetS) who were under 70 years of age with (n=17) and without (n=17) bilateral ELC, and assessed the relationship of ELC to atherosclerotic cardiovascular disease (AVD). The results showed that the TRF was shorter in the MetS patients with ELC in comparison to age- and risk-factor-matched MetS patients without ELC (7.6 +/- 1.1 kbp vs 8.6 +/- 1.2 kbp; P<0.05). ELC were present in 13 patients in the AVD group (n=18), but only 4 patients in the non-AVD group (n=16) had ELC (72.2% and 25% respectively; P<0.05).
   Conclusions These findings suggest that ELC is a useful dermatological indicator of an accelerated aging process, as suggested by excessive telomere loss, and might be a useful indirect marker of high-risk patients. (Circ J 2009; 73: 274-279)
C1 [Higuchi, Yoshihiro; Maeda, Toyoki; Guan, Jing-Zhi; Oyama, Junichi; Sugano, Masahiro; Makino, Naoki] Kyushu Univ, Med Inst Bioregulat, Dept Mol & Cellular Biol, Div Mol & Clin Gerontol, Beppu, Oita 8740838, Japan.
C3 Kyushu University
RP Higuchi, Y (corresponding author), Kyushu Univ, Med Inst Bioregulat, Dept Mol & Cellular Biol, Div Mol & Clin Gerontol, 4586 Tsurumihara, Beppu, Oita 8740838, Japan.
EM yhiguchi@beppu.kyushu-u.ac.jp
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   [Anonymous], 2005, Nihon Naika Gakkai Zasshi, V94, P794
   Aviv A, 2002, HYPERTENSION, V40, P229, DOI 10.1161/01.HYP.0000027280.91984.1B
   Benetos A, 2004, HYPERTENSION, V43, P182, DOI 10.1161/01.HYP.0000113081.42868.f4
   Brouilette SW, 2007, LANCET, V369, P107, DOI 10.1016/S0140-6736(07)60071-3
   Cherif H, 2003, NUCLEIC ACIDS RES, V31, P1576, DOI 10.1093/nar/gkg208
   DELANGE T, 1990, MOL CELL BIOL, V10, P518, DOI 10.1128/MCB.10.2.518
   Edston E, 2006, AM J FOREN MED PATH, V27, P129, DOI 10.1097/01.paf.0000221067.73173.d7
   ELLIOTT WJ, 1991, AM J MED, V91, P247, DOI 10.1016/0002-9343(91)90123-F
   Evrengül H, 2004, DERMATOLOGY, V209, P271, DOI 10.1159/000080847
   Finkel T, 2000, NATURE, V408, P239, DOI 10.1038/35041687
   FRANK ST, 1973, NEW ENGL J MED, V289, P327
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Guan JZ, 2008, J GERONTOL A-BIOL, V63, P467, DOI 10.1093/gerona/63.5.467
   Guan JZ, 2007, J GERONTOL A-BIOL, V62, P1199, DOI 10.1093/gerona/62.11.1199
   Guan JZ, 2007, MOL CELL BIOCHEM, V304, P353, DOI 10.1007/s11010-007-9518-2
   HARLEY CB, 1990, NATURE, V345, P458, DOI 10.1038/345458a0
   ISHII T, 1990, J AM GERIATR SOC, V38, P871, DOI 10.1111/j.1532-5415.1990.tb05702.x
   Koji Y, 2007, HYPERTENS RES, V30, P243, DOI 10.1291/hypres.30.243
   Kuri M, 2001, ANAESTHESIA, V56, P1160, DOI 10.1046/j.1365-2044.2001.02317.x
   LeBourg E, 1996, EXP GERONTOL, V31, P645, DOI 10.1016/S0531-5565(96)00098-8
   LICHSTEIN E, 1974, NEW ENGL J MED, V290, P615, DOI 10.1056/NEJM197403142901109
   McLeod AL, 2004, J HYPERTENS, V22, P363, DOI 10.1097/00004872-200402000-00021
   MOYZIS RK, 1988, P NATL ACAD SCI USA, V85, P6622, DOI 10.1073/pnas.85.18.6622
   Nakashima H, 2004, HYPERTENS RES, V27, P319, DOI 10.1291/hypres.27.319
   PASTERNAC A, 1982, CAN MED ASSOC J, V126, P645
   Samani NJ, 2001, LANCET, V358, P472, DOI 10.1016/S0140-6736(01)05633-1
   SHOENFELD Y, 1980, J AM GERIATR SOC, V28, P184, DOI 10.1111/j.1532-5415.1980.tb00514.x
   SLAGBOOM PE, 1994, AM J HUM GENET, V55, P876
   Taniguchi A, 2007, METABOLISM, V56, P1099, DOI 10.1016/j.metabol.2006.07.027
   TRANCHESI B, 1992, AM J CARDIOL, V70, P1417, DOI 10.1016/0002-9149(92)90292-7
   Valdes AM, 2005, LANCET, V366, P662, DOI 10.1016/S0140-6736(05)66630-5
   VAZIRI H, 1994, P NATL ACAD SCI USA, V91, P9857, DOI 10.1073/pnas.91.21.9857
   Von Zglinicki T, 2000, ANN NY ACAD SCI, V908, P99, DOI 10.1111/j.1749-6632.2000.tb06639.x
   Weber T, 2004, CIRCULATION, V109, P184, DOI 10.1161/01.CIR.0000105767.94169.E3
   Yamashina A, 2002, HYPERTENS RES, V25, P359, DOI 10.1291/hypres.25.359
NR 36
TC 47
Z9 49
U1 0
U2 2
PU JAPANESE CIRCULATION SOC
PI TOYKO
PA 18TH FLOOR IMPERIAL HOTEL TOWER, 1-1-1 UCHISAIWAI-CHO CHIYODA-KU, TOYKO,
   100-0011, JAPAN
SN 1346-9843
EI 1347-4820
J9 CIRC J
JI Circ. J.
PD FEB
PY 2009
VL 73
IS 2
BP 274
EP 279
DI 10.1253/circj.CJ-08-0267
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 399TN
UT WOS:000262822300015
PM 19060421
OA Bronze
DA 2025-06-11
ER

PT J
AU Hollman, G
   Kristenson, M
AF Hollman, Gunilla
   Kristenson, Margareta
TI The prevalence of the metabolic syndrome and its risk factors in a
   middle-aged Swedish population - Mainly a function of overweight?
SO EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
LA English
DT Article
DE Metabolic syndrome; Prevalence; Population
ID LOW-DENSITY-LIPOPROTEIN; HEALTH; TRENDS; PREDICTION; DISEASE; OBESITY;
   STRESS; WOMEN; MEN
AB Background: The prevalence of obesity, one risk factor for developing the metabolic syndrome (MS), has increased during the last decades. It has therefore been assumed that the prevalence of MS would also increase.
   Aims: The aim was to analyse the prevalence of MS and its risk factors in a middle-aged Swedish population.
   Methods: Data were obtained between 2003 and 2004 from a random population based sample of 502 men and 505 women, 45-69 years old. Measures of plasma glucose, serum lipids, blood pressure, weight, height, waist circumference and self-reported data concerning presence of disease, medication and lifestyle were obtained.
   Results: The prevalence of MS was 14.8% among men and 15.3% among women, with an increase by age among women only, 10% to 25% (p=0.029). Among individuals with MS the most frequent risk factor was large waist circumference, present in 85% of men and 99% of women, followed by high blood pressure, high triglycerides, high glucose and HDL cholesterol (38% and 47% respectively).
   Conclusion: The prevalence of MS was 15%, increasing with age only among women. Overweight was a dominant characteristic, and only half of the individuals with MS had glucose/HDL cholesterol levels beyond defined cut points of the syndrome. (C) 2007 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
C1 [Hollman, Gunilla] Linkoping Univ, Fac Hlth Sci, Div Nursing Sci, Dept Med & Care, S-58185 Linkoping, Sweden.
   [Kristenson, Margareta] Linkoping Univ, Fac Hlth Sci, Div Prevent & Social Med, Dept Hlth & Soc, S-58185 Linkoping, Sweden.
C3 Linkoping University; Linkoping University
RP Hollman, G (corresponding author), Linkoping Univ, Fac Hlth Sci, Div Nursing Sci, Dept Med & Care, S-58185 Linkoping, Sweden.
EM gunho@imv.liu.se
FU Swedish Heart and Lung Foundation [2004-1881]; Swedish Research Council
   [20040530]; Faculty of Health and Sciences, Linkoping University
FX We thank professor, Anders G Olsson, for introducing us into this field
   and for constructive criticism. We also thank the LSH study group for
   supportive discussions.We also thank the Swedish Heart and Lung
   Foundation (2004-1881), the Swedish Research Council (20040530) and the
   Faculty of Health and Sciences, Linkoping University for financial
   support.
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   [Anonymous], FOLKH
   Balkau B, 2002, DIABETES METAB, V28, P364
   Berg C, 2005, INT J OBESITY, V29, P916, DOI 10.1038/sj.ijo.0802964
   Cameron AJ, 2004, ENDOCRIN METAB CLIN, V33, P351, DOI 10.1016/j.ecl.2004.03.005
   Deedwania PC, 2004, CIRCULATION, V109, P2, DOI 10.1161/01.CIR.0000110642.73995.BF
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Eliasson M, 2002, DIABETIC MED, V19, P874, DOI 10.1046/j.1464-5491.2002.00789.x
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Girman CJ, 2005, AM J EPIDEMIOL, V162, P438, DOI 10.1093/aje/kwi229
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hjartåker A, 2005, EUR J EPIDEMIOL, V20, P747, DOI 10.1007/s10654-005-2145-x
   Horsten M, 1999, J CARDIOVASC RISK, V6, P391
   Ilanne-Parikka P, 2004, DIABETES CARE, V27, P2135, DOI 10.2337/diacare.27.9.2135
   Isomaa B, 2003, LIFE SCI, V73, P2395, DOI 10.1016/S0024-3205(03)00646-5
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   Laaksonen DE, 2004, ANN MED, V36, P332, DOI 10.1080/07853890410031849
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Larsson I., 2005, HUMAN BODY COMPOSITI
   Lauenborg J, 2005, J CLIN ENDOCR METAB, V90, P4004, DOI 10.1210/jc.2004-1713
   Li CY, 2006, DIABETES CARE, V29, P2396, DOI 10.2337/dc06-0289
   Neovius M, 2006, OBES REV, V7, P1, DOI 10.1111/j.1467-789x.2006.00190.x
   *NIH, 2002, 3 NECP EXP PAN DET E
   Nilsson PM, 2007, DIABETIC MED, V24, P464, DOI 10.1111/j.1464-5491.2007.02142.x
   Ninomiya JK, 2004, CIRCULATION, V109, P42, DOI 10.1161/01.CIR.0000108926.04022.0C
   Peltonen M, 1998, J INTERN MED, V244, P1, DOI 10.1046/j.1365-2796.1998.00289.x
   Scuteri A, 2005, DIABETES CARE, V28, P882, DOI 10.2337/diacare.28.4.882
   Sigurdardottir V, 2007, ATHEROSCLEROSIS, V190, P187, DOI 10.1016/j.atherosclerosis.2006.01.016
   Sjogren P, 2005, ARTERIOSCL THROM VAS, V25, P2580, DOI 10.1161/01.ATV.0000190675.08857.3d
   Vitaliano PP, 2002, PSYCHOSOM MED, V64, P418, DOI 10.1097/00006842-200205000-00006
   Wallenfeldt K, 2005, J INTERN MED, V258, P28, DOI 10.1111/j.1365-2796.2005.01511.x
   Wamala SP, 1999, DIABETES CARE, V22, P1999, DOI 10.2337/diacare.22.12.1999
NR 33
TC 43
Z9 50
U1 0
U2 3
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1474-5151
EI 1873-1953
J9 EUR J CARDIOVASC NUR
JI Eur. J. Cardiovasc. Nurs.
PD MAR
PY 2008
VL 7
IS 1
BP 21
EP 26
DI 10.1016/j.ejcnurse.2007.05.003
PG 6
WC Cardiac & Cardiovascular Systems; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Nursing
GA 368NG
UT WOS:000260627300006
PM 17586094
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Thomas, MS
   DiBella, M
   Blesso, CN
   Malysheva, O
   Caudill, M
   Sholola, M
   Cooperstone, JL
   Fernandez, ML
AF Thomas, Minu S.
   DiBella, Marissa
   Blesso, Christopher N.
   Malysheva, Olga
   Caudill, Marie
   Sholola, Maria
   Cooperstone, Jessica L.
   Fernandez, Maria Luz
TI Comparison between Egg Intake versus Choline Supplementation on Gut
   Microbiota and Plasma Carotenoids in Subjects with Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; gut microbiota; choline; TMAO; lutein; zeaxanthin
ID TRIMETHYLAMINE-N-OXIDE; OXIDATIVE STRESS; ANTIOXIDANT CONCENTRATIONS;
   ZEAXANTHIN CONCENTRATIONS; CARDIOVASCULAR-DISEASE; LOWER PREVALENCE;
   DIETARY CHOLINE; TMAO LEVELS; BETAINE; HOMOCYSTEINE
AB We previously demonstrated that intake of three eggs/d for 4 weeks increased plasma choline and decreased inflammation in subjects with metabolic syndrome (MetS). The purpose of the current study was to further explore the effects of phosphatidylcholine (PC) provided by eggs versus a choline bitartrate (CB) supplement on the gut microbiota, trimethylamine N-oxide (TMAO) formation, and plasma carotenoids lutein and zeaxanthin in MetS. This randomized, controlled crossover clinical trial included 23 subjects with MetS. Following a washout period of 2 weeks without consuming any choline-containing foods, subjects were randomly allocated to consume either three eggs/d or a CB supplement for 4 weeks (both diets had a choline equivalent of 400 mg/day). DNA was extracted from stool samples to sequence the 16S rRNA gene region for community analysis. Operational taxonomic units (OTUs) and the alpha-diversity of the community were determined using QIIME software. Plasma TMAO, methionine, betaine, and dimethylglycine (DMG) were quantified by stable isotope dilution liquid chromatography with tandem mass spectrometry. Plasma carotenoids, lutein, and zeaxanthin were measured using reversed-phase high-performance liquid chromatography. There were significant increases in plasma lutein and zeaxanthin after egg intake compared to the baseline or intake of CB supplement (p < 0.01). In contrast, TMAO was not different between treatments compared to the baseline (p > 0.05). Additionally, while diet intervention had no effects on microbiota diversity measures or relative taxa abundances, a correlation between bacterial biodiversity and HDL was observed. Following egg intake, the observed increases in plasma lutein and zeaxanthin may suggest additional protection against oxidative stress, a common condition in MetS.
C1 [Thomas, Minu S.; DiBella, Marissa; Blesso, Christopher N.; Fernandez, Maria Luz] Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
   [Malysheva, Olga; Caudill, Marie] Cornell Univ, Dept Human Nutr, Div Nutr Sciecnces, Ithaca, NY 14860 USA.
   [Sholola, Maria; Cooperstone, Jessica L.] Ohio State Univ, Dept Food Sci & Technol, Columbus, OH 43210 USA.
   [Cooperstone, Jessica L.] Ohio State Univ, Dept Hort & Crop Sci, Columbus, OH 43210 USA.
C3 University of Connecticut; Cornell University; University System of
   Ohio; Ohio State University; University System of Ohio; Ohio State
   University
RP Fernandez, ML (corresponding author), Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
EM minu.thomas@uconn.edu; marissa.dibella@uconn.edu;
   christopher.blesso@uconn.edu; ovm4@cornell.edu; mac279@cornell.edu;
   sholola.1@osu.edu; cooperstone.1@osu.edu; maria-luz.fernandez@uconn.edu
RI Blesso, Christopher/N-9495-2014; Thomas, Minu Sara/GOH-1463-2022
OI Fernandez, Maria-Luz/0000-0002-1835-0792; Caudill,
   Marie/0000-0002-7192-5743; Blesso, Christopher/0000-0002-4434-4839;
   Thomas, Minu Sara/0000-0002-1639-3086
FU Egg Nutrition Center
FX This study was funded by the Egg Nutrition Center.
CR Andraos S, 2021, CURR DEV NUTR, V5, DOI 10.1093/cdn/nzaa179
   Belzer C, 2012, ISME J, V6, P1449, DOI 10.1038/ismej.2012.6
   Bennett BJ, 2013, CELL METAB, V17, P49, DOI 10.1016/j.cmet.2012.12.011
   Beydoun MA, 2012, J NUTR, V142, P1693, DOI 10.3945/jn.112.160416
   Biddle MJ, 2015, J CARDIOVASC NURS, V30, P205, DOI 10.1097/JCN.0000000000000108
   Blesso CN, 2013, FOOD FUNCT, V4, P213, DOI 10.1039/c2fo30154g
   Clayton ZS, 2017, NUTRITION, V37, P79, DOI 10.1016/j.nut.2016.12.014
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cooperstone JL, 2015, MOL NUTR FOOD RES, V59, P658, DOI 10.1002/mnfr.201400658
   Coyne T, 2009, BRIT J NUTR, V102, P1668, DOI 10.1017/S000711450999081X
   CRAFT NE, 1993, J AGR FOOD CHEM, V41, P208, DOI 10.1021/jf00026a012
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   DiBella M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12103120
   DiMarco DM, 2017, J NUTR, V147, P323, DOI 10.3945/jn.116.241877
   DiNicolantonio JJ, 2019, OPEN HEART, V6, DOI 10.1136/openhrt-2018-000890
   Duncan SH, 2008, INT J OBESITY, V32, P1720, DOI 10.1038/ijo.2008.155
   Emamat H, 2020, CLIN NUTR ESPEN, V39, P15, DOI 10.1016/j.clnesp.2020.06.016
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Francisqueti FV, 2017, REV ASSOC MED BRAS, V63, P85
   Fu JY, 2015, CIRC RES, V117, P817, DOI 10.1161/CIRCRESAHA.115.306807
   Furet JP, 2010, DIABETES, V59, P3049, DOI 10.2337/db10-0253
   Goodrow EF, 2006, J NUTR, V136, P2519, DOI 10.1093/jn/136.10.2519
   Hammond BR, 2013, ADV NUTR, V4, P474, DOI 10.3945/an.113.004028
   Handelman GJ, 1999, AM J CLIN NUTR, V70, P247
   Hasan N, 2019, PEERJ, V7, DOI 10.7717/peerj.7502
   Hazen SL, 2014, AM J CLIN NUTR, V100, P741, DOI 10.3945/ajcn.114.094458
   Heianza Y, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.116.004947
   Holm PI, 2007, J CLIN ENDOCR METAB, V92, P1535, DOI 10.1210/jc.2006-1471
   Holm PI, 2004, ARTERIOSCL THROM VAS, V24, P301, DOI 10.1161/01.ATV.0000114569.54976.31
   Holm PI, 2003, CLIN CHEM, V49, P286, DOI 10.1373/49.2.286
   Janssen AWF, 2015, FASEB J, V29, P3111, DOI 10.1096/fj.14-269514
   Kayama Y, 2015, INT J MOL SCI, V16, P25234, DOI 10.3390/ijms161025234
   Kozich JJ, 2013, APPL ENVIRON MICROB, V79, P5112, DOI 10.1128/AEM.01043-13
   Kriaa A, 2019, J LIPID RES, V60, P323, DOI 10.1194/jlr.R088989
   Le Roy T, 2019, BMC BIOL, V17, DOI 10.1186/s12915-019-0715-8
   Lemos BS, 2018, J AM COLL NUTR, V37, P716, DOI 10.1080/07315724.2018.1466213
   Lemos BS, 2018, NUTRIENTS, V10, DOI 10.3390/nu10020258
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Li ZY, 2008, J LIPID RES, V49, P1187, DOI 10.1194/jlr.R700019-JLR200
   Liu J, 2014, BRIT J NUTR, V112, P2041, DOI 10.1017/S000711451400316X
   Louis S, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0149564
   Mente A, 2015, CAN J CARDIOL, V31, P1189, DOI 10.1016/j.cjca.2015.06.016
   Meyer KA, 2020, AM J CLIN NUTR, V111, P1115, DOI 10.1093/ajcn/nqaa068
   Meyer KA, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.116.003970
   Murillo AG, 2016, ADV NUTR, V7, P14, DOI 10.3945/an.115.009803
   Mutungi G, 2010, J NUTR BIOCHEM, V21, P261, DOI 10.1016/j.jnutbio.2008.12.011
   Niemann B, 2017, J AM COLL CARDIOL, V70, P230, DOI 10.1016/j.jacc.2017.05.043
   Oksanen J, 2022, VEGAN COMMUNITY ECOL
   Olthof MR, 2005, CURR DRUG METAB, V6, P15, DOI 10.2174/1389200052997366
   Pap R, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10030363
   Parker BJ, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.00906
   Qi JQ, 2018, J CELL MOL MED, V22, P185, DOI 10.1111/jcmm.13307
   Rabot S, 2010, FASEB J, V24, P4948, DOI 10.1096/fj.10-164921
   Randrianarisoa E, 2016, SCI REP-UK, V6, DOI 10.1038/srep26745
   Rinninella E, 2019, MICROORGANISMS, V7, DOI 10.3390/microorganisms7010014
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Rolo AP, 2012, FREE RADICAL BIO MED, V52, P59, DOI 10.1016/j.freeradbiomed.2011.10.003
   Schiattarella GG, 2019, EUR HEART J, V40, P2710, DOI 10.1093/eurheartj/ehz377
   Schoeler M, 2019, REV ENDOCR METAB DIS, V20, P461, DOI 10.1007/s11154-019-09512-0
   Schwab U, 2011, EUR J CLIN NUTR, V65, P70, DOI 10.1038/ejcn.2010.230
   Schwiertz A, 2010, OBESITY, V18, P190, DOI 10.1038/oby.2009.167
   Sekirov I, 2010, PHYSIOL REV, V90, P859, DOI 10.1152/physrev.00045.2009
   Sluijs I, 2009, J NUTR, V139, P987, DOI 10.3945/jn.108.101451
   Tang WHW, 2013, NEW ENGL J MED, V368, P1575, DOI 10.1056/NEJMoa1109400
   Thomas M.S., 2022, METAB SYNDR RELAT DI
   Tveitevåg Svingen GF, 2013, ARTERIOSCL THROM VAS, V33, P2041, DOI 10.1161/ATVBAHA.113.301714
   U.S. Department of Health and Human Services & U.S. Department of Agriculture, 2015, 2015 2020 DIET GUID
   Ueland PM, 2005, CLIN CHEM LAB MED, V43, P1069, DOI 10.1515/CCLM.2005.187
   Ufnal M, 2015, NUTRITION, V31, P1317, DOI 10.1016/j.nut.2015.05.006
   Vourakis M, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22158074
   Wang MX, 2019, NUTR METAB CARDIOVAS, V29, P653, DOI 10.1016/j.numecd.2019.04.004
   Wang PX, 2020, CHINESE MED J-PEKING, V133, P808, DOI 10.1097/CM9.0000000000000696
   Wang Q, 2007, APPL ENVIRON MICROB, V73, P5261, DOI 10.1128/AEM.00062-07
   Wang ZN, 2011, NATURE, V472, P57, DOI 10.1038/nature09922
   Wickham H, 2011, J STAT SOFTW, V40, P1, DOI 10.18637/jss.v040.i01
   Wilcox J, 2021, AM J MED, V134, P1160, DOI 10.1016/j.amjmed.2021.03.016
   Wutthi-in M, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-67078-3
   Yin J, 2015, J AM HEART ASSOC, V4, DOI 10.1161/JAHA.115.002699
   Zhou Q, 2021, DIABET METAB SYND OB, V14, P2177, DOI 10.2147/DMSO.S311388
   Zhu CH, 2020, NUTR RES, V78, P36, DOI 10.1016/j.nutres.2020.04.002
   Zhu W, 2018, J THROMB HAEMOST, V16, P1857, DOI 10.1111/jth.14234
   Zhu WF, 2017, CIRCULATION, V135, P1671, DOI 10.1161/CIRCULATIONAHA.116.025338
   Zhu WF, 2016, CELL, V165, P111, DOI 10.1016/j.cell.2016.02.011
NR 84
TC 13
Z9 14
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2022
VL 14
IS 6
AR 1179
DI 10.3390/nu14061179
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 0E1HK
UT WOS:000776434600001
PM 35334836
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Simao, TNC
   Lozovoy, MAB
   Simao, ANC
   Oliveira, SR
   Venturini, D
   Morimoto, HK
   Miglioranza, LHS
   Dichi, I
AF Colado Simao, Tathiana Name
   Batisti Lozovoy, Marcell Alysson
   Colado Simao, Andrea Name
   Oliveira, Sayonara Rangel
   Venturini, Danielle
   Morimoto, Helena Kaminami
   Silva Miglioranza, Lucia Helena
   Dichi, Isaias
TI Reduced-energy cranberry juice increases folic acid and adiponectin and
   reduces homocysteine and oxidative stress in patients with the metabolic
   syndrome
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Metabolic syndrome; Cranberry juice; Folic acid; Adiponectin;
   Homocysteine
ID PLASMA ANTIOXIDANT CAPACITY; ADIPOSE-SPECIFIC PROTEIN;
   CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; GRAPE JUICE; VITAMIN INTERVENTION; ISCHEMIC-STROKE;
   RISK-FACTORS
AB The metabolic syndrome (MetS) comprises pathological conditions that include insulin resistance, arterial hypertension, visceral adiposity and dyslipidaemia, which favour the development of CVD. Some reports have shown that cranberry ingestion reduces cardiovascular risk factors. However, few studies have evaluated the effect of this fruit in subjects with the MetS. The objective of the present study was to assess the effect of reduced-energy cranberry juice consumption on metabolic and inflammatory biomarkers in patients with the MetS, and to verify the effects of cranberry juice concomitantly on homocysteine and adiponectin levels in patients with the MetS. For this purpose, fifty-six individuals with the MetS were selected and divided into two groups: control group (n 36) and cranberry-treated group (n 20). After consuming reduced-energy cranberry juice (0.7 litres/d) containing 0.4mg folic acid for 60 d, the cranberry-treated group showed an increase in adiponectin (P=0.010) and folic acid (P=0.033) and a decrease in homocysteine (P<0.001) in relation to baseline values and also in comparison with the controls (P<0.05). There was no significant change in the pro-inflammatory cytokines TNF-alpha, IL-1 and IL-6. In relation to oxidative stress measurements, decreased (P<0.05) lipoperoxidation and protein oxidation levels assessed by advanced oxidation protein products were found in the cranberry-treated group when compared with the control group. In conclusion, the consumption of cranberry juice for 60 d was able to improve some cardiovascular risk factors. The present data reinforce the importance of the inverse association between homocysteine and adiponectin and the need for more specifically designed studies on MetS patients.
C1 [Colado Simao, Tathiana Name] Philadelphia Univ Ctr UNIFIL Londrina, Dept Nutr, Londrina, Parana, Brazil.
   [Batisti Lozovoy, Marcell Alysson] Univ North Parana UNOPAR, Dept Clin Anal, Londrina, Parana, Brazil.
   [Colado Simao, Andrea Name; Oliveira, Sayonara Rangel; Venturini, Danielle; Morimoto, Helena Kaminami] Univ Londrina, Dept Pathol Clin Anal & Toxicol, BR-86038440 Londrina, Parana, Brazil.
   [Silva Miglioranza, Lucia Helena] Univ Londrina, Dept Food Sci & Technol, BR-86038440 Londrina, Parana, Brazil.
   [Dichi, Isaias] Univ Londrina, Dept Internal Med, BR-86038440 Londrina, Parana, Brazil.
C3 University Norte Parana
RP Dichi, I (corresponding author), Univ Londrina, Dept Internal Med, Robert Koch Ave 60, BR-86038440 Londrina, Parana, Brazil.
EM dichi@sercomtel.com.br
RI Simão, Andrea/AAM-4892-2021; Venturini, Danielle/HPH-1330-2023;
   Miglioranza, Lucia/H-1656-2012; Lozovoy, Marcell/AAM-4897-2021
FU National Council of Brazilian Research - CNPq
FX The present study was supported by the National Council of Brazilian
   Research - CNPq. Juxx Company supplied the cranberry juice. The authors'
   contributions are as follows: T. N. C. S., A. N. C. S. and I. D.
   designed the research; T. N. C. S., A. N. C. S., M. A. B. L., D. V., L.
   H. S. M. and H. K. M. conducted the research; T. N. C. S., A. N. C. S.
   and I. D. analysed the data; T. N. C. S., A. N. C. S. and I. D. wrote
   the paper; I. D. had primary responsibility for the final content. All
   authors read and approved the final manuscript. None of the authors had
   any conflict of interest in relation to the present study.
CR Albert CM, 2008, JAMA-J AM MED ASSOC, V299, P2027, DOI 10.1001/jama.299.17.2027
   Arita Y, 1999, BIOCHEM BIOPH RES CO, V257, P79, DOI 10.1006/bbrc.1999.0255
   Badawy A, 2006, EU J OBSTET GYNECOL, V5, P112
   Basu A, 2011, NUTR RES, V31, P190, DOI 10.1016/j.nutres.2011.02.003
   Beattie J, 2005, CURR NUTR FOOD SCI, V1, P71, DOI 10.2174/1573401052953294
   Bere E, 2007, EUR J CLIN NUTR, V61, P431, DOI 10.1038/sj.ejcn.1602512
   Bonaa KH, 2006, NEW ENGL J MED, V354, P1578, DOI 10.1056/NEJMoa055227
   Casas JP, 2005, LANCET, V365, P224, DOI 10.1016/S0140-6736(05)70152-5
   Charles C, 2009, MENOPAUSE, V16, P395, DOI 10.1097/gme.0b013e3181857979
   Clarke R, 2002, JAMA-J AM MED ASSOC, V288, P2015, DOI 10.1001/jama.288.16.2015
   Simao ANC, 2012, BRIT J NUTR, V108, P1435, DOI 10.1017/S0007114511006921
   Côté J, 2010, CRIT REV FOOD SCI, V50, P666, DOI 10.1080/10408390903044107
   Cronin S, 2005, STROKE, V36, P1581, DOI 10.1161/01.STR.0000169946.31639.af
   Dichi I, 2012, EXPERT OPIN THER TAR, V16, P147, DOI 10.1517/14728222.2012.648924
   Dominguez LJ, 2010, J AM COLL NUTR, V29, P1
   Ebbing M, 2008, JAMA-J AM MED ASSOC, V300, P795, DOI 10.1001/jama.300.7.795
   Ekmekçi H, 2009, J THROMB THROMBOLYS, V28, P418, DOI 10.1007/s11239-008-0292-0
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   FLECHA BG, 1991, FREE RADICAL BIO MED, V10, P93
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   Freedman JE, 2001, CIRCULATION, V103, P2792, DOI 10.1161/01.CIR.103.23.2792
   Fried SK, 1998, J CLIN ENDOCR METAB, V83, P847, DOI 10.1210/jc.83.3.847
   Fruchart JC, 2004, CIRCULATION, V109, P15, DOI 10.1161/01.CIR.0000131513.33892.5b
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Hayden MR, 2004, NUTR J, V3, DOI 10.1186/1475-2891-3-4
   Heinonen M, 2007, MOL NUTR FOOD RES, V51, P684, DOI 10.1002/mnfr.200700006
   Hotta K, 2001, DIABETES, V50, P1126, DOI 10.2337/diabetes.50.5.1126
   Hotta K, 2000, ARTERIOSCL THROM VAS, V20, P1595, DOI 10.1161/01.ATV.20.6.1595
   Itoh M, 2007, ARTERIOSCL THROM VAS, V27, P1918, DOI 10.1161/ATVBAHA.106.136853
   Iwashima Y, 2004, HYPERTENSION, V43, P1318, DOI 10.1161/01.HYP.0000129281.03801.4b
   Jacobs Jr DR, 2001, JAMA-J AM MED ASSOC, V285, P2486
   Kähkönen MP, 1999, J AGR FOOD CHEM, V47, P3954, DOI 10.1021/jf990146l
   Kallio P, 2007, AM J CLIN NUTR, V85, P1417, DOI 10.1093/ajcn/85.5.1417
   Kawashima A, 2007, ASIA PAC J CLIN NUTR, V16, P411
   Keevil JG, 2000, J NUTR, V130, P53
   Kern PA, 2001, AM J PHYSIOL-ENDOC M, V280, pE745
   Lara JJ, 2007, ATHEROSCLEROSIS, V193, P213, DOI 10.1016/j.atherosclerosis.2006.06.018
   Lee IT, 2008, DIABETIC MED, V25, P1473, DOI 10.1111/j.1464-5491.2008.02588.x
   Lichtenstein AH, 2005, JAMA-J AM MED ASSOC, V294, P351, DOI 10.1001/jama.294.3.351
   Lonn E, 2006, NEW ENGL J MED, V354, P1567, DOI 10.1056/NEJMoa060900
   Lozovoy MAB, 2011, LUPUS, V20, P1250, DOI 10.1177/0961203311411350
   Maahs DM, 2005, CIRCULATION, V111, P747, DOI 10.1161/01.CIR.0000155251.03724.A5
   Maeda N, 2001, DIABETES, V50, P2094, DOI 10.2337/diabetes.50.9.2094
   Martínez-Flórez S, 2005, J NUTR, V135, P1359, DOI 10.1093/jn/135.6.1359
   McAnulty LS, 2011, APPL PHYSIOL NUTR ME, V36, P976, DOI [10.1139/h11-120, 10.1139/H11-120]
   Mckay DL, 2007, NUTR REV, V65, P490, DOI 10.1301/nr.2007.nov.490-502
   Moat SJ, 2004, AM J PHYSIOL-HEART C, V287, pH1, DOI 10.1152/ajpheart.00952.2003
   Nagasawa A, 2002, HORM METAB RES, V34, P635, DOI 10.1055/s-2002-38254
   Nijveldt RJ, 2001, AM J CLIN NUTR, V74, P418
   O'Byrne DJ, 2002, AM J CLIN NUTR, V76, P1367, DOI 10.1093/ajcn/76.6.1367
   Ouchi N, 2000, CIRCULATION, V102, P1296, DOI 10.1161/01.CIR.102.11.1296
   Ouchi N, 1999, CIRCULATION, V100, P2473, DOI 10.1161/01.CIR.100.25.2473
   Panunzio MF, 2003, NUTR RES, V23, P1221, DOI 10.1016/S0271-5317(03)00133-7
   Paterson E, 2006, J NUTR, V136, P2849, DOI 10.1093/jn/136.11.2849
   Pedersen CB, 2000, EUR J CLIN NUTR, V54, P405, DOI 10.1038/sj.ejcn.1600972
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Ruel G, 2005, METABOLISM, V54, P856, DOI 10.1016/j.metabol.2005.01.031
   Ruel G, 2008, BRIT J NUTR, V99, P352, DOI 10.1017/S0007114507811986
   Ruel G, 2007, MOL NUTR FOOD RES, V51, P692, DOI 10.1002/mnfr.200600286
   Salehpour S, 2008, INT J FERTIL STERIL, V2, P101
   Samman S, 2003, J NUTR, V133, P2188, DOI 10.1093/jn/133.7.2188
   Santos AC, 2005, INT J OBESITY, V29, P1452, DOI 10.1038/sj.ijo.0803035
   Selhub J, 2006, J NUTR, V136, p1726S, DOI 10.1093/jn/136.6.1726S
   Setola E, 2004, EUR J ENDOCRINOL, V151, P483, DOI 10.1530/eje.0.1510483
   Sieminska L, 2004, J ENDOCRINOL INVEST, V27, P528, DOI 10.1007/BF03347474
   Simao ANC, 2012, J NUTR METAB, P1
   Song ZY, 2008, HEPATOLOGY, V47, P867, DOI 10.1002/hep.22074
   Spence JD, 2005, STROKE, V36, P2404, DOI 10.1161/01.STR.0000185929.38534.f3
   Tamakoshi K, 2003, INT J OBESITY, V27, P443, DOI 10.1038/sj.ijo.0802260
   Toole JF, 2004, JAMA-J AM MED ASSOC, V291, P565, DOI 10.1001/jama.291.5.565
   Tyagi N, 2005, AM J PHYSIOL-HEART C, V289, pH2649, DOI 10.1152/ajpheart.00548.2005
   U.S. Pharmacopeia, 2007, USP FOL AC REF STAND, P3276
   Wald DS, 2002, BMJ-BRIT MED J, V325, P1202, DOI 10.1136/bmj.325.7374.1202
   Wang Y, 2002, J AGR FOOD CHEM, V50, P431, DOI 10.1021/jf010812u
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Williamson G, 2005, AM J CLIN NUTR, V81, p243S, DOI 10.1093/ajcn/81.1.243S
   Witko-Sarsat V, 1998, J IMMUNOL, V161, P2524
   Yang QH, 2006, CIRCULATION, V113, P1335, DOI 10.1161/CIRCULATIONAHA.105.570846
   Yokota T, 2000, BLOOD, V96, P1723, DOI 10.1182/blood.V96.5.1723
   Youdim KA, 2002, J NUTR BIOCHEM, V13, P282, DOI 10.1016/S0955-2863(01)00221-2
   Yudkin JS, 2000, ATHEROSCLEROSIS, V148, P209, DOI 10.1016/S0021-9150(99)00463-3
   Zhu WD, 2008, CLIN SCI, V114, P361, DOI 10.1042/CS20070347
   Ziemke F, 2010, AM J CLIN NUTR, V91, p258S, DOI 10.3945/ajcn.2009.28449C
NR 83
TC 52
Z9 54
U1 0
U2 22
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD NOV 28
PY 2013
VL 110
IS 10
BP 1885
EP 1894
DI 10.1017/S0007114513001207
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 250VF
UT WOS:000326883600016
PM 23750500
OA Bronze
DA 2025-06-11
ER

PT J
AU Zhao, XJ
   Chen, L
   Zhao, Y
   Pan, Y
   Yang, YZ
   Sun, Y
   Jiao, RQ
   Kong, LD
AF Zhao, Xiao-Juan
   Chen, Li
   Zhao, Yue
   Pan, Ying
   Yang, Yan-Zi
   Sun, Yang
   Jiao, Rui-Qing
   Kong, Ling-Dong
TI Polygonum cuspidatum extract attenuates fructose-induced liver
   lipid accumulation through inhibiting Keap1 and activating Nrf2
   antioxidant pathway
SO PHYTOMEDICINE
LA English
DT Article
DE Polygonum cuspidatum extract; Fructose; Liver lipid accumulation;
   Keap1/Nrf2 pathway
ID INDUCED HEPATIC STEATOSIS; NLRP3 INFLAMMASOME; OXIDATIVE STRESS;
   METABOLIC SYNDROME; ACID; MICE; EXPRESSION; INJURY
AB Background: Polygonum cuspidatum has been used in traditional Chinese medicine to treat liver disorders associated with oxidative stress, inflammation and lipid accumulation for centuries in patients.
   Purpose: The aim of this study was to examine whether P. cuspidatum extract (PCE) prevented against fructose-induced liver lipid accumulation via regulating Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
   Method: PCE was administered orally to male Sprague-Dawley rats given 10% fructose drinking water for 6 weeks at 80 and 160 mg/kg once daily for 11 weeks.
   Results: PCE significantly alleviated liver lipid accumulation in fructose-fed rats with metabolic syndrome. It also inhibited Keap1, activated Nrf2 antioxidant pathway, resulting in the suppression of oxidative stress, evidenced by reducing hydrogen peroxide (H2O2), malondialdehyde (MDA) and hydroxy radical (OH center dot) levels, and increasing glutathione (GSH)/oxidized glutathione (GSSG) ratio as well as superoxidase dismutase (SOD) and catalase (CAT) activity in the liver of fructose-fed rats. Additionally, PCE up-regulated peroxisome proliferator activated receptor-alpha (PPAR-alpha), and down-regulated sterol regulatory element binging protein 1 (SREBP-1), fatty acid synthetase (FAS) and stearoyl-CoA desaturase-1 (SCD-1) in this animal model, being consistent with its reduction of triglyceride (TG) levels.
   Conclusion: These results demonstrate that PCE reduces oxidative stress, and prevent lipid accumulation in the liver of fructose-fed rats possibly by targeting the Keap1/Nrf2 pathway. PCE may be a promising therapeutic strategy for fructose-associated liver lipid accumulation.
C1 [Zhao, Xiao-Juan; Chen, Li; Zhao, Yue; Pan, Ying; Yang, Yan-Zi; Sun, Yang; Jiao, Rui-Qing; Kong, Ling-Dong] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China.
C3 Nanjing University
RP Kong, LD (corresponding author), Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China.
EM kongld@nju.edu.cn
FU National Natural Science Foundation of China [81573667, 81730105]
FX This work was supported by Grant from National Natural Science
   Foundation of China (Nos. 81573667 and 81730105) to Ling-Dong Kong.
CR Alisi A, 2012, INT J MOL SCI, V13, P2276, DOI 10.3390/ijms13022276
   Cai SM, 2016, ANTIOXID REDOX SIGN, V24, P795, DOI 10.1089/ars.2015.6498
   Chen WM, 2016, EXP THER MED, V11, P1231, DOI 10.3892/etm.2016.3077
   Florian M, 2004, STEROIDS, V69, P779, DOI 10.1016/j.steroids.2004.09.008
   Gómez-Zubeldia MA, 2001, MENOPAUSE, V8, P274
   Han L, 2017, FUTUR CARDIOL, V13, DOI 10.2217/fca-2016-0059
   Jia R, 2019, COMP BIOCHEM PHYS C, V215, P56, DOI 10.1016/j.cbpc.2018.10.002
   Kim YS, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-282
   Lee D.H., 2019, CHITINASE 3 LIKE 1 D
   Liu BH, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00347
   Liu CL, 2002, FOOD CHEM TOXICOL, V40, P635, DOI 10.1016/S0278-6915(02)00002-9
   Liu XT, 2017, ANTIOXID REDOX SIGN, V26, P28, DOI 10.1089/ars.2015.6615
   Lou J.Y., 2014, J ZHJIANG TRADIT CHI, V49, P400
   Lu CF, 2015, IUBMB LIFE, V67, P645, DOI 10.1002/iub.1409
   Ma KL, 2008, HEPATOLOGY, V48, P770, DOI 10.1002/hep.22423
   Ma WG, 2019, CHIN J INTEGR MED, V25, P182, DOI 10.1007/s11655-017-2979-6
   Michelucci A, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/6936897
   Nigro D, 2017, J NUTR BIOCHEM, V42, P160, DOI 10.1016/j.jnutbio.2017.01.010
   Pakdeechote P, 2014, NUTRIENTS, V6, P355, DOI 10.3390/nu6010355
   Peng W, 2013, J ETHNOPHARMACOL, V148, P729, DOI 10.1016/j.jep.2013.05.007
   Qian S.J., 2017, J JINGGANGSHAN U, V38, P96
   Sohn E, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030140
   Sohn E, 2015, MOL MED REP, V12, P5837, DOI 10.3892/mmr.2015.4214
   Sohn E, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-477
   Spahis S, 2017, ANTIOXID REDOX SIGN, V26, P519, DOI 10.1089/ars.2016.6776
   SUGIOKA K, 1987, FEBS LETT, V210, P37, DOI 10.1016/0014-5793(87)81293-0
   Tang LY, 2016, CAN J PHYSIOL PHARM, V94, P185, DOI 10.1139/cjpp-2015-0125
   Vitonyte J, 2017, EUR J PHARM BIOPHARM, V114, P278, DOI 10.1016/j.ejpb.2017.02.004
   Vos MB, 2013, HEPATOLOGY, V57, P2525, DOI 10.1002/hep.26299
   Wagner AH, 2001, FASEB J, V15, P2121, DOI 10.1096/fj.01-0123com
   Wang S., 2016, HEPATOL RES, V47, P683
   Wassmann S, 2001, CIRCULATION, V103, P435
   Wu GZ, 2017, ANTIOXID REDOX SIGN, V27, P754, DOI 10.1089/ars.2016.6885
   Wu KC, 2012, TOXICOL APPL PHARM, V262, P321, DOI 10.1016/j.taap.2012.05.010
   Xia SF, 2018, FOOD FUNCT, V9, P906, DOI 10.1039/c7fo01051f
   Yang M, 2018, BIOMED PHARMACOTHER, V105, P1283, DOI 10.1016/j.biopha.2018.06.108
   Zhang X, 2015, ANTIOXID REDOX SIGN, V22, P848, DOI 10.1089/ars.2014.5868
   Zhao XJ, 2018, REDOX BIOL, V18, P124, DOI 10.1016/j.redox.2018.07.002
   Zhao XJ, 2017, EUR J PHARMACOL, V809, P141, DOI 10.1016/j.ejphar.2017.05.032
   Zhou Q.H., 1985, J SHANXI TRADIT CHIN, V6, P42
NR 40
TC 26
Z9 28
U1 6
U2 39
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD OCT
PY 2019
VL 63
AR 152986
DI 10.1016/j.phymed.2019.152986
PG 9
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA JR5YD
UT WOS:000499699300005
PM 31310912
DA 2025-06-11
ER

PT J
AU Feng, SD
   Zeng, YK
   Song, FM
   Shen, MX
   Yang, F
AF Feng, Shuidong
   Zeng, Yuke
   Song, Fengmei
   Shen, Minxue
   Yang, Fei
TI Microcystins Exposure and the Risk of Metabolic Syndrome: A
   Cross-Sectional Study in Central China
SO TOXINS
LA English
DT Article
DE microcystins; metabolic syndrome; mediation; cross-sectional study
ID OXIDATIVE STRESS; UNITED-STATES; RAT-LIVER; MC-LR; DISEASE;
   INFLAMMATION; OBESITY; TRENDS; COUNT
AB A growing body of evidence indicates that microcystins (MCs) exposure may cause metabolic diseases. However, studies exploring the effects of MCs exposure on the risk of metabolic syndrome (MetS) in humans are currently lacking, and the underlying mechanisms remain unclear. Here, we conducted a cross-sectional study in central China to explore the effect of serum MCs on MetS, and assessed the mediation effects of the inflammation biomarker, white blood cell (WBC) level, in this relationship. The relationships among MCs and WBC level and risk of MetS were assessed using binary logistic and linear regression. Mediation analysis was used to explore possible mechanisms underlying those associations by employing R software (version 4.3.1). Compared to the lowest quartile of MCs, the highest quartile had an increased risk of MetS (odds ratio [OR] = 2.10, 95% confidence interval [CI]: 1.19, 3.70), with a dose-response relationship (p for trend < 0.05). WBCs mediated 11.14% of the association between serum MCs and triglyceride (TG) levels, but did not mediate the association of MCs exposure with MetS. This study firstly reveals that MCs exposure is an independent risk factor for MetS in a dose-response manner, and suggests that WBC level could partially mediate the association of MCs exposure with TG levels.
C1 [Feng, Shuidong; Zeng, Yuke; Song, Fengmei; Yang, Fei] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Dept Epidemiol & Hlth Stat,Key Lab Typ Environm Po, Hengyang 421001, Peoples R China.
   [Shen, Minxue] Cent South Univ, Xiangya Sch Publ Hlth, Dept Social Med & Hlth Management, Hunan Prov Key Lab Clin Epidemiol, Changsha 410000, Peoples R China.
C3 University of South China; Central South University
RP Yang, F (corresponding author), Univ South China, Sch Publ Hlth, Hengyang Med Sch, Dept Epidemiol & Hlth Stat,Key Lab Typ Environm Po, Hengyang 421001, Peoples R China.; Shen, MX (corresponding author), Cent South Univ, Xiangya Sch Publ Hlth, Dept Social Med & Hlth Management, Hunan Prov Key Lab Clin Epidemiol, Changsha 410000, Peoples R China.
EM shuidong_f@hotmail.com; yukezeng09@gmail.com; songfengmei2020@163.com;
   shenmx1988@csu.edu.cn; yangfeilong@126.com
RI Yang, Fei/H-7058-2019; Shen, Minxue/P-5140-2019
OI Yang, Fei/0000-0001-5687-0556; Shen, Minxue/0000-0003-0441-9303
FU Key Research and Development Projects in Hunan Province;  [2022SK2089]
FX This research was funded by the Key Research and Development Projects in
   Hunan Province (2022SK2089).
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Bai J, 2023, TOXICON, V235, DOI 10.1016/j.toxicon.2023.107313
   Bishehsari F, 2020, NAT REV ENDOCRINOL, V16, P731, DOI 10.1038/s41574-020-00427-4
   Bouaïcha N, 2019, TOXINS, V11, DOI 10.3390/toxins11120714
   Chan KL, 2019, PHYSIOLOGY, V34, P123, DOI 10.1152/physiol.00047.2018
   Chen J, 2009, TOXICOL SCI, V108, P81, DOI 10.1093/toxsci/kfp009
   Chen L, 2021, SCI TOTAL ENVIRON, V764, DOI 10.1016/j.scitotenv.2020.142319
   Chen L, 2016, ENVIRON TOXICOL, V31, P552, DOI 10.1002/tox.22068
   Chen L, 2016, J HAZARD MATER, V301, P381, DOI 10.1016/j.jhazmat.2015.08.041
   Chmielewski PP, 2018, FOLIA MORPHOL, V77, P171, DOI 10.5603/FM.a2017.0101
   Chu HY, 2022, TOXINS, V14, DOI 10.3390/toxins14120833
   Després JP, 2008, ARTERIOSCL THROM VAS, V28, P1039, DOI 10.1161/ATVBAHA.107.159228
   Du C, 2022, ECOTOX ENVIRON SAFE, V239, DOI 10.1016/j.ecoenv.2022.113649
   Feng SD, 2023, TOXINS, V15, DOI 10.3390/toxins15040293
   Feng SD, 2022, ENVIRON SCI TECHNOL, V56, P15818, DOI 10.1021/acs.est.2c02287
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   Guo MH, 2023, FOOD CHEM TOXICOL, V182, DOI 10.1016/j.fct.2023.114189
   Guo XC, 2014, J CHROMATOGR B, V963, P54, DOI 10.1016/j.jchromb.2014.05.046
   Han SC, 2022, ENVIRON RES, V215, DOI 10.1016/j.envres.2022.114340
   He P, 2021, BIOL TRACE ELEM RES, V199, P2573, DOI 10.1007/s12011-020-02397-0
   Hedayati MT, 2021, CASP J INTERN MED, V12, P59, DOI 10.22088/cjim.12.1.59
   Hernandez BY, 2022, MICROORGANISMS, V10, DOI 10.3390/microorganisms10081607
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Ibelings BW, 2007, ENVIRON POLLUT, V150, P177, DOI 10.1016/j.envpol.2007.04.012
   Jia JM, 2016, TOXINS, V8, DOI 10.3390/toxins8060170
   Kirk EP, 2009, J CLIN HYPERTENS, V11, P761, DOI 10.1111/j.1559-4572.2009.00054.x
   Li XB, 2014, ENVIRON SCI POLLUT R, V21, P12419, DOI 10.1007/s11356-014-3151-x
   Li XY, 2019, ECOTOX ENVIRON SAFE, V169, P28, DOI 10.1016/j.ecoenv.2018.10.110
   Li YC, 2024, TOXINS, V16, DOI 10.3390/toxins16030149
   Li ZY, 2021, CHEMOSPHERE, V264, DOI 10.1016/j.chemosphere.2020.128505
   Lin W, 2022, ECOTOX ENVIRON SAFE, V229, DOI 10.1016/j.ecoenv.2021.113054
   Lin Y, 2023, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.1047866
   Lone Y, 2016, J TOXICOL-US, V2016, DOI 10.1155/2016/8048125
   Lu JL, 2017, J CLIN ENDOCR METAB, V102, P507, DOI 10.1210/jc.2016-2477
   Ma JG, 2018, CHEMOSPHERE, V192, P305, DOI 10.1016/j.chemosphere.2017.10.158
   Madjid M, 2004, J AM COLL CARDIOL, V44, P1945, DOI 10.1016/j.jacc.2004.07.056
   Massey IY, 2018, TOXICON, V151, P156, DOI 10.1016/j.toxicon.2018.07.010
   McGlynn KA, 2021, HEPATOLOGY, V73, P4, DOI 10.1002/hep.31288
   Mérida DM, 2023, ENVIRON POLLUT, V333, DOI 10.1016/j.envpol.2023.121957
   Murray CJ., 2020, Lancet, V396, P1223, DOI [10.1016/s0140-6736(20)30752-2, DOI 10.1016/S0140-6736(20)30752-2, 10.1016/S0140-6736(20)30752-2]
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Palmer MK, 2019, OBESITY, V27, P309, DOI 10.1002/oby.22370
   Qin WD, 2015, ENVIRON TOXICOL PHAR, V40, P114, DOI 10.1016/j.etap.2015.05.002
   Raya-Cano E, 2023, J CLIN MED, V12, DOI 10.3390/jcm12227044
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Tingley D, 2014, J STAT SOFTW, V59
   Wang X, 2022, ENVIRON RES, V210, DOI 10.1016/j.envres.2022.112976
   Wei J, 2020, ENVIRON POLLUT, V256, DOI 10.1016/j.envpol.2019.113444
   Xiang L, 2019, ENVIRON INT, V133, DOI 10.1016/j.envint.2019.105142
   Yang F, 2020, WATER RES, V174, DOI 10.1016/j.watres.2020.115638
   Yang F, 2019, CHEMOSPHERE, V226, P321, DOI 10.1016/j.chemosphere.2019.03.171
   Yang Y, 2022, J HAZARD MATER, V440, DOI 10.1016/j.jhazmat.2022.129793
   Yao XQ, 2023, TOXINS, V15, DOI 10.3390/toxins15060404
   Zeng H, 2021, ECOTOX ENVIRON SAFE, V212, DOI 10.1016/j.ecoenv.2021.111990
   Zeng H, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-05791-2
   Zhang HQ, 2012, SEMIN CELL DEV BIOL, V23, P722, DOI 10.1016/j.semcdb.2012.03.017
   Zhang RL, 2023, BMC CANCER, V23, DOI 10.1186/s12885-022-10479-6
   Zhang ZY, 2016, J HAZARD MATER, V315, P126, DOI 10.1016/j.jhazmat.2016.05.011
   Zhao YY, 2020, ENVIRON INT, V138, DOI 10.1016/j.envint.2020.105648
   Zhao YY, 2015, TOXICOLOGY, V328, P135, DOI 10.1016/j.tox.2014.12.007
   Zhong SZ, 2020, TOXICON, V174, P19, DOI 10.1016/j.toxicon.2019.12.152
NR 61
TC 1
Z9 1
U1 2
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6651
J9 TOXINS
JI Toxins
PD DEC
PY 2024
VL 16
IS 12
AR 542
DI 10.3390/toxins16120542
PG 12
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA Q5X2B
UT WOS:001385396900001
PM 39728800
OA gold
DA 2025-06-11
ER

PT J
AU Johari, SM
   Shahar, S
AF Johari, Sa'ida Munira
   Shahar, Suzana
TI Metabolic syndrome: The association of obesity and unhealthy lifestyle
   among Malaysian elderly people
SO ARCHIVES OF GERONTOLOGY AND GERIATRICS
LA English
DT Article
DE Metabolic syndrome; Risk factors; Elderly; Malaysia
ID TIME PHYSICAL-ACTIVITY; C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE;
   PREVALENCE; MORTALITY; RISK; POPULATION; ATHEROSCLEROSIS; QUESTIONNAIRE;
   INFLAMMATION
AB The aim of this study is to investigate the prevalence of metabolic syndrome (MetS) and its predictors among Malaysian elderly. A total of 343 elderly aged >= 60 years residing low cost flats in an urban area in the central of Malaysia were invited to participate in health screening in community centers. Subjects were interviewed to obtain socio demography, health status and behavior data. Anthropometric measurements were also measured. A total of 30 ml fasting blood was taken to determine fasting serum lipid, glucose level and oxidative stress. MetS was classified according to The International Diabetes Federation (IDF) criteria. The prevalence of MetS was 43.4%. More women (48.1%) were affected than men (36.3%) (p < 0.05). Being obese or overweight was the strongest predictor for MetS in men and women (p < 0.05, both gender). High carbohydrate intake increased risk of MetS in men by 2.8 folds. In women, higher fat free mass index, physical inactivity and good appetite increased risk of MetS by 3.9, 2.1 and 2.3 folds respectively. MetS affected almost half of Malaysian elderly being investigated, especially women, and is associated with obesity and unhealthy lifestyle. It is essential to develop preventive and intervention strategies to curb undesirable consequences associated with MetS. (C) 2014 Published by Elsevier Ireland Ltd.
C1 [Johari, Sa'ida Munira; Shahar, Suzana] Univ Kebangsaan Malaysia, Fac Hlth Sci, Sch Healthcare Sci, Kuala Lumpur 50300, Malaysia.
C3 Universiti Kebangsaan Malaysia
RP Shahar, S (corresponding author), Univ Kebangsaan Malaysia, Fac Hlth Sci, Sch Healthcare Sci, Kuala Lumpur 50300, Malaysia.
EM suzana.shahar@gmail.com
FU Universiti Kebangsaan Malaysia [UKM-GUP-SK-07-21-041]; Ministry of
   Science, Technology and Innovation [06-01-02-SF0551]
FX This project was partly funded by research grants from Universiti
   Kebangsaan Malaysia (UKM-GUP-SK-07-21-041) and Ministry of Science,
   Technology and Innovation (06-01-02-SF0551). The authors would like to
   acknowledge the contribution of the co-researchers and fieldworkers
   involved in this study. Many thanks are extended to the participants and
   staff at the community centers.
CR Akbulut G., 2001, ARCH GERONTOLOGY GER
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Arai H, 2010, J CLIN GERONTOL GERI, V1, P42, DOI 10.1016/j.jcgg.2010.10.011
   Barinas-Mitchell E, 2001, AM J EPIDEMIOL, V153, P1094, DOI 10.1093/aje/153.11.1094
   Bee Ying Tan Jr, 2008, Malays J Nutr, V14, P65
   Carnethon M. R., 2003, CIRCULATION S4, V108, P728
   Chan JCN, 2002, INT J OBESITY, V26, P994, DOI 10.1038/sj.ijo.0802017
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Cho ER, 2009, ANN EPIDEMIOL, V19, P784, DOI 10.1016/j.annepidem.2009.06.010
   Department of Malaysian Statistic, 2000, KEN MED LAP TAB PEND
   Diaz VA, 2007, DIABETIC MED, V24, P1199, DOI 10.1111/j.1464-5491.2007.02244.x
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Festa A, 2001, INT J OBESITY, V25, P1407, DOI 10.1038/sj.ijo.0801792
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Freire RD, 2005, DIABETES CARE, V28, P1779, DOI 10.2337/diacare.28.7.1779
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Geffken DF, 2001, AM J EPIDEMIOL, V153, P242, DOI 10.1093/aje/153.3.242
   Grundy SM, 2007, J CLIN ENDOCR METAB, V92, P399, DOI 10.1210/jc.2006-0513
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Gu D, 2003, DIABETOLOGIA, V46, P1190, DOI 10.1007/s00125-003-1167-8
   Gu DF, 2005, LANCET, V365, P1398, DOI 10.1016/S0140-6736(05)66375-1
   Hagströmer M, 2006, PUBLIC HEALTH NUTR, V9, P755, DOI 10.1079/PHN2005898
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Katzmarzyk PT, 2003, MED SCI SPORT EXER, V35, P1703, DOI 10.1249/01.MSS.0000089337.73244.9B
   Laaksonen DE, 2003, DIABETES CARE, V26, P2156, DOI 10.2337/diacare.26.7.2156
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lee R., 1993, ANTHROPOMETRY NUTR A
   Liu SM, 2001, AM J CLIN NUTR, V73, P560
   Ma G, 2008, OBES REV, V9, P113, DOI 10.1111/j.1467-789X.2007.00451.x
   Mirmiran P, 2008, NUTR METAB CARDIOVAS, V18, P567, DOI 10.1016/j.numecd.2007.06.002
   Misra A, 2002, NUTRITION, V18, P702, DOI 10.1016/S0899-9007(02)00818-3
   Mohamad H A Jr, 2010, Malays J Nutr, V16, P339
   Mohamed-Ali V, 1997, J CLIN ENDOCR METAB, V82, P4196, DOI 10.1210/jc.82.12.4196
   Mohamud WNW, 2011, DIABETES RES CLIN PR, V91, P239, DOI 10.1016/j.diabres.2010.11.025
   Parker BA, 2004, APPETITE, V43, P227, DOI 10.1016/j.appet.2004.05.004
   Pasceri V, 2000, CIRCULATION, V102, P2165
   Pearson TA, 2002, CIRCULATION, V106, P388, DOI 10.1161/01.CIR.0000020190.45892.75
   Rabieyah M., 2003, SOCIOECONOMIC CHARAC
   Ravaglia G, 2006, DIABETES CARE, V29, P2471, DOI 10.2337/dc06-0282
   Regidor E, 2004, EUR J CLIN NUTR, V58, P488, DOI 10.1038/sj.ejcn.1601835
   Roberts CK, 2001, HYPERTENSION, V37, P1323, DOI 10.1161/01.HYP.37.5.1323
   Roux AVD, 2002, CIRCULATION, V106, P703, DOI 10.1161/01.CIR.0000025402.84600.CD
   Sakkinen PA, 2000, AM J EPIDEMIOL, V152, P897, DOI 10.1093/aje/152.10.897
   Schlenker E. D., 1998, NUTR AGEING
   Schols AMWJ, 2005, AM J CLIN NUTR, V82, P53, DOI 10.1093/ajcn/82.1.53
   Serrano R, 2009, MECH AGEING DEV, V130, P189, DOI 10.1016/j.mad.2008.11.005
   Stratton RJ, 2006, BRIT J NUTR, V95, P325, DOI 10.1079/BJN20051622
   Suzana S., 2000, MAL J NUTR, V6, P33
   Wang BY, 2010, J AM GERIATR SOC, V58, P2027, DOI 10.1111/j.1532-5415.2010.03078.x
   WHO Expert Consultation, 2004, APPR BMI AS POP POL
   Wilson MMG, 2005, AM J CLIN NUTR, V82, P1074, DOI 10.1093/ajcn/82.5.1074
   Woolf K, 2008, J AM DIET ASSOC, V108, P948, DOI 10.1016/j.jada.2008.03.015
   Yu ZJ, 2009, PREV MED, V48, P272, DOI 10.1016/j.ypmed.2009.01.004
   Yusuf S, 2005, LANCET, V366, P1640, DOI 10.1016/S0140-6736(05)67663-5
NR 56
TC 17
Z9 17
U1 1
U2 23
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-4943
EI 1872-6976
J9 ARCH GERONTOL GERIAT
JI Arch. Gerontol. Geriatr.
PD SEP-OCT
PY 2014
VL 59
IS 2
BP 360
EP 366
DI 10.1016/j.archger.2014.04.003
PG 7
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA AO0RE
UT WOS:000341018300023
PM 24882592
DA 2025-06-11
ER

PT J
AU Mortimer, KRH
   Katshu, MZU
   Chakrabarti, L
AF Mortimer, Katherine R. H.
   Katshu, Mohammed Zia Ul Haq
   Chakrabarti, Lisa
TI Second-generation antipsychotics and metabolic syndrome: a role for
   mitochondria
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE antipsychotics; psychosis; mitochondria; energy metabolism; metabolic
   syndrome
ID ENERGY-METABOLISM; OXIDATIVE STRESS; OLANZAPINE; SCHIZOPHRENIA;
   CLOZAPINE; DRUGS; AMPK; AGRANULOCYTOSIS; DYSREGULATION; ASSOCIATION
AB Psychosis is a known risk factor for developing metabolic syndrome (MetS). The risk is even greater in patients who are taking second-generation antipsychotics (SGAs). SGAs exacerbate metabolic abnormalities and lead to a 3-fold increased risk of severe weight gain, type 2 diabetes, and cardiovascular disease in patients. Mitochondrial dysfunction is a hallmark of MetS. Mitochondria process glucose and fatty acids into ATP. If these processes are impaired, it can result in dyslipidaemia, hyperglycaemia and an imbalance between nutrient input and energy output. This leads to increased adiposity, insulin resistance and atherosclerosis. It is unclear how SGAs induce MetS and how mitochondria might be involved in this process. It has been found that SGAs impair cellular glucose uptake in liver, dysregulating glucose and fatty acid metabolism which leads to an accumulation of glucose and/or lipids and an increase reactive oxygen species (ROS) which target mitochondrial proteins. This affects complexes of the electron transport chain (ETC) to reduce mitochondrial respiration. While there is a suggestion that SGAs may interact with a variety of processes that disrupt mitochondrial function, some of the results are conflicting, and a clear picture of how SGAs interact with mitochondria in different cell types has not yet emerged. Here, we outline the current evidence showing how SGAs may trigger mitochondrial dysfunction and lead to the development of MetS.
C1 [Mortimer, Katherine R. H.; Chakrabarti, Lisa] Univ Nottingham, Sch Vet Med & Sci, Nottingham, England.
   [Katshu, Mohammed Zia Ul Haq] Univ Nottingham, Sch Med, Inst Mental Hlth, Nottingham, England.
   [Katshu, Mohammed Zia Ul Haq] Nottinghamshire Healthcare NHS Fdn Trust, Nottingham, England.
C3 University of Nottingham; University of Nottingham
RP Chakrabarti, L (corresponding author), Univ Nottingham, Sch Vet Med & Sci, Nottingham, England.
EM Lisa.Chakrabarti@nottingham.ac.uk
RI Chakrabarti, Lisa/G-4236-2011
OI Katshu, Mohammad Zia Ul Haq/0000-0002-1301-3359; Mortimer,
   Katherine/0000-0001-8788-2306
FU Biotechnology and Biological Sciences Research Council [BB/J014508/1]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. KM is funded by the
   Biotechnology and Biological Sciences Research Council (grant number
   BB/J014508/1).
CR Albaugh VL, 2012, SCHIZOPHRENIA BULL, V38, P153, DOI 10.1093/schbul/sbq053
   Arseneault L, 2004, BRIT J PSYCHIAT, V184, P110, DOI 10.1192/bjp.184.2.110
   Bhatti JS, 2017, BBA-MOL BASIS DIS, V1863, P1066, DOI 10.1016/j.bbadis.2016.11.010
   Braslow JT, 2019, ANNU REV CLIN PSYCHO, V15, P25, DOI 10.1146/annurev-clinpsy-050718-095514
   Bugger H, 2008, CLIN SCI, V114, P195, DOI 10.1042/CS20070166
   BURKHARDT C, 1993, ANN NEUROL, V33, P512, DOI 10.1002/ana.410330516
   Byrne P, 2007, BMJ-BRIT MED J, V334, P686, DOI 10.1136/bmj.39148.668160.80
   Calabrese J., 2022, StatPearls [Internet]. Treasure Island (FL)
   Carli M, 2021, PHARMACEUTICALS-BASE, V14, DOI 10.3390/ph14030238
   Casademont J, 2007, J CLIN PSYCHOPHARM, V27, P284, DOI 10.1097/JCP.0b013e318054753e
   Chadda RK, 2013, J PHARMACOL PHARMACO, V4, P176, DOI 10.4103/0976-500X.114596
   Chong HY, 2014, VALUE HEALTH, V17, pA767, DOI 10.1016/j.jval.2014.08.293
   Cikánková T, 2019, N-S ARCH PHARMACOL, V392, P1209, DOI 10.1007/s00210-019-01665-8
   Citrome Leslie, 2006, Neuropsychiatr Dis Treat, V2, P427, DOI 10.2147/nedt.2006.2.4.427
   Citrome L, 2019, NEUROPSYCH DIS TREAT, V15, P2559, DOI 10.2147/NDT.S209284
   Contreras-Shannon V, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059012
   Correll, 2018, WORLD PSYCHIATRY, V17, P120, DOI 10.1002/wps.20503
   Cunningham Owens David, 2018, Brain Neurosci Adv, V2, p2398212818817498, DOI 10.1177/2398212818817498
   Eftekhari A, 2016, XENOBIOTICA, V46, P369, DOI 10.3109/00498254.2015.1078522
   Fabrazzo M, 2022, J CLIN MED, V11, DOI 10.3390/jcm11154530
   Fatemi SH, 2006, NEUROPSYCHOPHARMACOL, V31, P1888, DOI 10.1038/sj.npp.1301002
   Gonzalez-Franquesa A, 2017, ADV EXP MED BIOL, V982, P465, DOI 10.1007/978-3-319-55330-6_25
   Guo CY, 2013, NEURAL REGEN RES, V8, P2003, DOI 10.3969/j.issn.1673-5374.2013.21.009
   Hasnain M, 2010, CURR DIABETES REP, V10, P209, DOI 10.1007/s11892-010-0112-8
   He M, 2014, PSYCHONEUROENDOCRINO, V42, P153, DOI 10.1016/j.psyneuen.2014.01.018
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   IDANPAANHEIKKILA J, 1977, EUR J CLIN PHARMACOL, V11, P193, DOI 10.1007/BF00606409
   Ikegami M, 2013, EUR J PHARMACOL, V718, P376, DOI 10.1016/j.ejphar.2013.08.006
   KANE J, 1988, ARCH GEN PSYCHIAT, V45, P789
   Khan AH, 2017, CUREUS J MED SCIENCE, V9, DOI 10.7759/cureus.1973
   Kikuchi T, 2021, NEUROPSYCHOPHARM REP, V41, P134, DOI 10.1002/npr2.12180
   Kim DD, 2021, NPJ SCHIZOPHR, V7, DOI 10.1038/s41537-021-00158-z
   Kim MK, 2012, INT J NEUROPSYCHOPH, V15, P907, DOI 10.1017/S1461145711000976
   Klingerman CM, 2014, SCHIZOPHRENIA BULL, V40, P327, DOI 10.1093/schbul/sbs196
   Lahdelma L, 2012, J CLIN PSYCHIAT, V73, P837, DOI 10.4088/JCP.11m07244
   Leverve X., 2006, SEPSIS NEW INSIGHTS, V280
   Li P, 2016, CURR TOP MED CHEM, V16, P3385, DOI 10.2174/1568026616666160608084834
   Li R, 2021, BIOMED PHARMACOTHER, V141, DOI 10.1016/j.biopha.2021.111803
   Long YC, 2006, J CLIN INVEST, V116, P1776, DOI 10.1172/JCI29044
   Mailman RB, 2010, CURR PHARM DESIGN, V16, P488, DOI 10.2174/138161210790361461
   MELTZER HY, 1994, J CLIN PSYCHIAT, V55, P47
   Mijovic A, 2020, ANN HEMATOL, V99, P2477, DOI 10.1007/s00277-020-04215-y
   National Institute for Health and Clinical Excellence, 2019, 2019 EXCEPTIONAL SUR
   Newcomer JW, 2002, ARCH GEN PSYCHIAT, V59, P337, DOI 10.1001/archpsyc.59.4.337
   Oh KJ, 2011, AM J PHYSIOL-ENDOC M, V300, pE24, DOI 10.1152/ajpendo.00502.2010
   Okada M, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23169103
   Papanastasiou E, 2013, THER ADV PSYCHOPHARM, V3, P33, DOI 10.1177/2045125312464385
   Pillinger T, 2020, LANCET PSYCHIAT, V7, P64, DOI 10.1016/S2215-0366(19)30416-X
   Purcell RH, 2023, SCI ADV, V9, DOI 10.1126/sciadv.adh0558
   Radojcic MR, 2023, LANCET PSYCHIAT, V10, P119, DOI 10.1016/S2215-0366(22)00404-7
   San-Millan I, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12040782
   Sanger TM, 1999, AM J PSYCHIAT, V156, P79, DOI 10.1176/ajp.156.1.79
   Scaini G, 2018, EUR NEUROPSYCHOPHARM, V28, P369, DOI 10.1016/j.euroneuro.2018.01.004
   Schmidt RH, 2013, J PHARMACOL EXP THER, V347, P126, DOI 10.1124/jpet.113.207621
   Shoham N, 2021, SCHIZOPHR RES, V228, P97, DOI 10.1016/j.schres.2020.11.057
   Sipos I, 2003, J NEUROCHEM, V84, P112, DOI 10.1046/j.1471-4159.2003.01513.x
   Stapel B, 2017, J PSYCHIATR RES, V88, P18, DOI 10.1016/j.jpsychires.2016.12.012
   Sykes DA, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00716-z
   Szasz M, 2025, J LIQ CHROMATOGR R T, V48, P138, DOI 10.1080/10826076.2023.2216780
   Taipale H, 2020, WORLD PSYCHIATRY, V19, P61, DOI 10.1002/wps.20699
   Tan EJ, 2022, CURR OPIN PSYCHIATR, V35, P140, DOI 10.1097/YCO.0000000000000784
   Tandon R, 2020, ANN GEN PSYCHIATR, V19, DOI 10.1186/s12991-020-00292-5
   VanderKruik R, 2017, BMC PSYCHIATRY, V17, DOI 10.1186/s12888-017-1427-7
   Walss-Bass C, 2008, INT J NEUROPSYCHOPH, V11, P1097, DOI 10.1017/S1461145708008882
   Weston-Green K, 2022, FRONT PSYCHIATRY, V13, DOI 10.3389/fpsyt.2022.903156
   Yuen JWY, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.609240
   Zorova LD, 2018, ANAL BIOCHEM, V552, P50, DOI 10.1016/j.ab.2017.07.009
NR 67
TC 7
Z9 7
U1 1
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD NOV 24
PY 2023
VL 14
AR 1257460
DI 10.3389/fpsyt.2023.1257460
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AA3D0
UT WOS:001115682000001
PM 38076704
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ahn, BI
   Kim, MJ
   Koo, HS
   Seo, N
   Joo, NS
   Kim, YS
AF Ahn, Bang-In
   Kim, Moon Jong
   Koo, Hyung Suk
   Seo, Namkyung
   Joo, Nam-Seok
   Kim, Young-Sang
TI Serum Zinc Concentration Is Inversely Associated with Insulin Resistance
   but Not Related with Metabolic Syndrome in Nondiabetic Korean Adults
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Zinc; Serum zinc concentration; Insulin resistance; Metabolic syndrome;
   Korean
ID DENSITY-LIPOPROTEIN-CHOLESTEROL; OXIDATIVE STRESS; SUPPLEMENTATION;
   RISK; COMPONENTS
AB Although zinc was known to be associated with insulin metabolism and diabetes, the relationship of serum zinc concentration with insulin resistance (IR) and metabolic syndrome (MetS) was not well investigated in general population. The aim of this study is to evaluate the relationships of serum zinc concentration with IR and MetS in a nondiabetic adult population. This cross-sectional study included 656 men and 825 women who were nondiabetic adults from the fifth Korea National Health and Nutrition Examination Survey conducted in 2010. Serum zinc concentration and metabolic parameters were measured. IR was estimated by homeostatic model assessment (HOMA2). MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria. Serum zinc concentration was negatively correlated with homeostasis model assessment for insulin resistance (HOMA2-IR) in men (r = -0.104, P = 0.008), but not in women. After adjusting for conventional cardiovascular risk factors, the inverse correlation was significant in both men and women (B = -0.262, SE = 0.060 for men, and B = -0.129, SE = 0.052 for women). However, serum zinc concentration was not different between the groups with and without MetS (P = 0.752 for men and P = 0.371 for women). In conclusion, serum zinc concentration was inversely associated with IR but not related to MetS in nondiabetic adult population.
C1 [Ahn, Bang-In; Kim, Moon Jong; Koo, Hyung Suk; Seo, Namkyung; Kim, Young-Sang] CHA Med Univ, Dept Family Med, CHA Bundang Med Ctr, Songnam 463712, Gyeonggi Do, South Korea.
   [Joo, Nam-Seok] Ajou Univ, Sch Med, Dept Family Med, Gyeonggi Do, South Korea.
C3 Ajou University
RP Kim, YS (corresponding author), CHA Med Univ, Dept Family Med, CHA Bundang Med Ctr, 59 Yatap Ro, Songnam 463712, Gyeonggi Do, South Korea.
EM zeroup@cha.ac.kr
RI Kim, Mark/HZH-8733-2023
OI Kim, Young-Sang/0000-0002-7397-5410
CR Anetor J I, 2002, Nutr Health, V16, P291
   Chimienti F, 2013, NUTR RES REV, V26, P1, DOI 10.1017/S0954422412000212
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Czernichow S, 2009, AM J CLIN NUTR, V90, P329, DOI 10.3945/ajcn.2009.27635
   DEFRONZO RA, 1979, AM J PHYSIOL, V237, pE214
   Farvid MS, 2004, DIABETES RES CLIN PR, V65, P21, DOI 10.1016/j.diabres.2003.11.009
   FREELANDGRAVES JH, 1982, AM J CLIN NUTR, V35, P988, DOI 10.1093/ajcn/35.5.988
   Ghasemi A, 2014, ANN HUM BIOL, V41, P436, DOI 10.3109/03014460.2013.870228
   Gunasekara P, 2011, DIABET METAB SYND OB, V4, P53, DOI 10.2147/DMSO.S16691
   Haase H, 2005, BIOMETALS, V18, P333, DOI 10.1007/s10534-005-3707-9
   Hashemipour M, 2009, HORM-INT J ENDOCRINO, V8, P279, DOI 10.14310/horm.2002.1244
   HOOPER PL, 1980, JAMA-J AM MED ASSOC, V244, P1960, DOI 10.1001/jama.244.17.1960
   Institute NRRD, 2006, FOOD COMP TABL
   Islam MR, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061776
   KOO SI, 1983, AM J CLIN NUTR, V37, P918, DOI 10.1093/ajcn/37.6.918
   Krebs NF, 2000, J NUTR, V130, p1374S, DOI 10.1093/jn/130.5.1374S
   Lann D, 2007, MED CLIN N AM, V91, P1063, DOI 10.1016/j.mcna.2007.06.012
   Lee SY, 2007, DIABETES RES CLIN PR, V75, P72, DOI 10.1016/j.diabres.2006.04.013
   LEVINE AS, 1983, AM J CLIN NUTR, V37, P382, DOI 10.1093/ajcn/37.3.382
   Yubero-Serrano EM, 2013, EXP MOL MED, V45, DOI 10.1038/emm.2013.53
   Marreiro DD, 2006, BIOL TRACE ELEM RES, V112, P109, DOI 10.1385/BTER:112:2:109
   Obeid O, 2008, BIOL TRACE ELEM RES, V123, P58, DOI 10.1007/s12011-008-8112-0
   Ortega RM, 2012, BRIT J NUTR, V107, P398, DOI 10.1017/S0007114511003114
   Pizent A, 2010, J NUTR HEALTH AGING, V14, P866, DOI 10.1007/s12603-010-0139-1
   Roussel AM, 2003, J AM COLL NUTR, V22, P316, DOI 10.1080/07315724.2003.10719310
   Simon SF, 2001, EXP BIOL MED, V226, P43, DOI 10.1177/153537020122600107
   Singh RB, 1998, J AM COLL NUTR, V17, P564, DOI 10.1080/07315724.1998.10718804
   Suarez-Ortegón MF, 2013, AM J HUM BIOL, V25, P550, DOI 10.1002/ajhb.22408
   Suliburska J, 2013, EUR REV MED PHARMACO, V17, P2396
   Sun Q, 2009, DIABETES CARE, V32, P629, DOI 10.2337/dc08-1913
   Tang XH, 2001, J NUTR, V131, P1414, DOI 10.1093/jn/131.5.1414
   VANDERSCHOUW YT, 1992, FAM PRACT, V9, P506, DOI 10.1093/fampra/9.4.506
   Wallace TM, 2004, DIABETES CARE, V27, P1487, DOI 10.2337/diacare.27.6.1487
   Wiernsperger NF, 2003, DIABETES METAB, V29, P579, DOI 10.1016/S1262-3636(07)70072-1
   Xu JC, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/635214
   Yu YH, 2012, NUTR RES, V32, P71, DOI 10.1016/j.nutres.2011.12.004
   ZALEWSKI PD, 1994, J HISTOCHEM CYTOCHEM, V42, P877, DOI 10.1177/42.7.8014471
NR 37
TC 42
Z9 45
U1 0
U2 3
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD AUG
PY 2014
VL 160
IS 2
BP 169
EP 175
DI 10.1007/s12011-014-0045-1
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA AL7VC
UT WOS:000339343300003
PM 24943234
DA 2025-06-11
ER

PT J
AU Yuyama, K
   Mitsutake, S
   Igarashi, Y
AF Yuyama, Kohei
   Mitsutake, Susumu
   Igarashi, Yasuyuki
TI Pathological roles of ceramide and its metabolites in metabolic syndrome
   and Alzheimer's disease
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
LA English
DT Review
DE Sphingolipid; Glycosphingolipid; Ceramide; Sphingomyelin; Metabolic
   syndrome; Alzheimer's disease
ID AMYLOID-BETA-PEPTIDE; INDUCED INSULIN-RESISTANCE; MILD COGNITIVE
   IMPAIRMENT; PRECURSOR PROTEIN; SPHINGOLIPID METABOLISM; GAMMA-SECRETASE;
   OXIDATIVE STRESS; LIPID MICRODOMAINS; IN-VIVO; CHOLESTEROL
AB The public health burden of metabolic syndrome (MetS), a multiplex risk factor that arises from insulin resistance accompanying abnormal adipose conditions, and Alzheimer's disease (AD), the most common form of dementia, continues to expand. Current available therapies for these disorders are of limited effectiveness. Recent findings have indicated that alternations in sphingolipid metabolism contribute to the development of these pathologies. Sphingolipids are major constituents of the plasma membrane, where they are known to form several types of microdomains, and are potent regulators for a variety of physiological processes. Many groups, including ours, have demonstrated that membrane sphingolipids, especially ceramide and its metabolites such as ceramide 1-phosphate, have roles in arteriosclerosis, obesity, diabetes, and inflammation associated with MetS. Aberrant sphingolipid profiles have been observed in human AD brains, and accumulated evidence has demonstrated that changes in membrane properties induced by defective sphingolipid metabolism impair generation and degradation of amyloid-beta peptide (A beta), a pathogenic agent of AD. In this review, we summarize current knowledge and pathophysiological implications of the roles of SLs in MetS and AD, to provide insight into the SL metabolic pathways as potential targets for therapy of these diseases. This article is part of a Special Issue entitled New Frontiers in Sphingolipid Biology. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Yuyama, Kohei; Mitsutake, Susumu; Igarashi, Yasuyuki] Hokkaido Univ, Grad Sch Adv Life Sci, Frontier Res Ctr Postgenome Sci & Technol, Lab Biomembrane & Biofunct Chem, Sapporo, Hokkaido 0010021, Japan.
C3 Hokkaido University
RP Mitsutake, S (corresponding author), Hokkaido Univ, Fac Adv Life Sci, Kita Ku, Kita 21,Nishi 11, Sapporo, Hokkaido 0010021, Japan.
EM susumu-m@pharm.hokudai.ac.jp
RI Mitsutake, Susumu/A-4082-2012
CR Abad-Rodriguez J, 2004, J CELL BIOL, V167, P953, DOI 10.1083/jcb.200404149
   Abbott A, 2011, NATURE, V475, pS2, DOI 10.1038/475S2a
   Alessenko AV, 2004, BIOCHEM SOC T, V32, P144, DOI 10.1042/BST0320144
   Ariga T, 2008, J LIPID RES, V49, P1157, DOI 10.1194/jlr.R800007-JLR200
   Bandaru VVR, 2009, NEUROBIOL AGING, V30, P591, DOI 10.1016/j.neurobiolaging.2007.07.024
   Bell CG, 2005, NAT REV GENET, V6, P221, DOI 10.1038/nrg1556
   Bornancin F, 2011, CELL SIGNAL, V23, P999, DOI 10.1016/j.cellsig.2010.11.012
   Butterfield DA, 2007, FREE RADICAL BIO MED, V43, P658, DOI 10.1016/j.freeradbiomed.2007.05.037
   Cheng H, 2010, NEUROBIOL AGING, V31, P1188, DOI 10.1016/j.neurobiolaging.2008.07.020
   Cole SL, 2005, J BIOL CHEM, V280, P18755, DOI 10.1074/jbc.M413895200
   Cutler RG, 2004, P NATL ACAD SCI USA, V101, P2070, DOI 10.1073/pnas.0305799101
   de la Monte SM, 2012, J ALZHEIMERS DIS, V30, pS231, DOI 10.3233/JAD-2012-111727
   Farooqui AA, 2011, LIPID MEDIATORS AND THEIR METABOLISM IN THE BRAIN, P1, DOI 10.1007/978-1-4419-9940-5
   Farooqui AA, 2012, CELL MOL LIFE SCI, V69, P741, DOI 10.1007/s00018-011-0840-1
   Fitzner D, 2011, J CELL SCI, V124, P447, DOI 10.1242/jcs.074088
   Fuentealba RA, 2007, MOL NEURODEGENER, V2, DOI 10.1186/1750-1326-2-14
   FUJITA T, 1994, J ANTIBIOT, V47, P208, DOI 10.7164/antibiotics.47.208
   Geekiyanage H, 2011, J NEUROSCI, V31, P14820, DOI 10.1523/JNEUROSCI.3883-11.2011
   Grimm MOW, 2005, NAT CELL BIOL, V7, P1118, DOI 10.1038/ncb1313
   Gulbins E, 2003, ONCOGENE, V22, P7070, DOI 10.1038/sj.onc.1207146
   Haffner SM, 2006, AM J CARDIOL, V97, p3A, DOI 10.1016/j.amjcard.2005.11.010
   Han XL, 2010, BBA-MOL CELL BIOL L, V1801, P774, DOI 10.1016/j.bbalip.2010.01.010
   Han XL, 2002, J NEUROCHEM, V82, P809, DOI 10.1046/j.1471-4159.2002.00997.x
   Hannun YA, 2008, NAT REV MOL CELL BIO, V9, P139, DOI 10.1038/nrm2329
   Hansen GH, 2000, J BIOL CHEM, V275, P5136, DOI 10.1074/jbc.275.7.5136
   Hardy J, 2002, SCIENCE, V297, P353, DOI 10.1126/science.1072994
   Hayashi H, 2004, J NEUROSCI, V24, P4894, DOI 10.1523/JNEUROSCI.0861-04.2004
   He XX, 2010, NEUROBIOL AGING, V31, P398, DOI 10.1016/j.neurobiolaging.2008.05.010
   Hirabayashi Y., 2006, Sphingolipid biology
   Hojjati MR, 2005, J BIOL CHEM, V280, P10284, DOI 10.1074/jbc.M412348200
   Holland WL, 2008, ENDOCR REV, V29, P381, DOI 10.1210/er.2007-0025
   Holland WL, 2007, CELL METAB, V5, P167, DOI 10.1016/j.cmet.2007.01.002
   Holland WL, 2011, J CLIN INVEST, V121, P1858, DOI 10.1172/JCI43378
   Huang Y, 2004, EUR J NEUROSCI, V20, P3489, DOI 10.1111/j.1460-9568.2004.03852.x
   Huitema K, 2004, EMBO J, V23, P33, DOI 10.1038/sj.emboj.7600034
   Hur JY, 2008, FEBS J, V275, P1174, DOI 10.1111/j.1742-4658.2008.06278.x
   Igbavboa U, 2005, J NEUROL SCI, V229, P225, DOI 10.1016/j.jns.2004.11.037
   Izquierdo-Useros N, 2009, BLOOD, V113, P2732, DOI 10.1182/blood-2008-05-158642
   Kaether C, 2004, J CELL BIOL, V167, P809, DOI 10.1083/jcb.200410090
   Kalvodova L, 2005, J BIOL CHEM, V280, P36815, DOI 10.1074/jbc.M504484200
   Kapoor A, 2010, J ALZHEIMERS DIS, V22, P423, DOI 10.3233/JAD-2010-100531
   Katsel P, 2007, NEUROCHEM RES, V32, P845, DOI 10.1007/s11064-007-9297-x
   Katsuda T, 2013, SCI REP-UK, V3, DOI 10.1038/srep01197
   Kolesnick R, 2003, ONCOGENE, V22, P5897, DOI 10.1038/sj.onc.1206702
   Kosaka N, 2013, J BIOL CHEM, V288, P10849, DOI 10.1074/jbc.M112.446831
   Lajoie P, 2007, J CELL MOL MED, V11, P644, DOI 10.1111/j.1582-4934.2007.00083.x
   Lee JT, 2004, J CELL BIOL, V164, P123, DOI 10.1083/jcb.200307017
   Lee SJ, 1998, NAT MED, V4, P730, DOI 10.1038/nm0698-730
   Malaplate-Armand C, 2006, NEUROBIOL DIS, V23, P178, DOI 10.1016/j.nbd.2006.02.010
   Mielke MM, 2010, ALZHEIMERS DEMENT, V6, P378, DOI 10.1016/j.jalz.2010.03.014
   Mitsutake S, 2007, BIOCHEM BIOPH RES CO, V359, P622, DOI 10.1016/j.bbrc.2007.05.160
   Mitsutake S, 2013, VITAM HORM, V91, P271, DOI 10.1016/B978-0-12-407766-9.00012-2
   Mitsutake S, 2012, FEBS LETT, V586, P1300, DOI 10.1016/j.febslet.2012.03.032
   Mitsutake S, 2011, J BIOL CHEM, V286, P28544, DOI 10.1074/jbc.M111.255646
   Ogretmen B, 2004, NAT REV CANCER, V4, P604, DOI 10.1038/nrc1411
   Patel P.S., 2013, J OBES IN PRESS
   Pettegrew JW, 2001, NEUROCHEM RES, V26, P771, DOI 10.1023/A:1011603916962
   Puglielli L, 2003, J BIOL CHEM, V278, P19777, DOI 10.1074/jbc.M300466200
   Puglielli L, 2001, NAT CELL BIOL, V3, P905, DOI 10.1038/ncb1001-905
   Rajendran L, 2006, P NATL ACAD SCI USA, V103, P11172, DOI 10.1073/pnas.0603838103
   Runz H, 2002, J NEUROSCI, V22, P1679, DOI 10.1523/JNEUROSCI.22-05-01679.2002
   Sawamura N, 2004, J BIOL CHEM, V279, P11984, DOI 10.1074/jbc.M309832200
   Stancevic B, 2010, FEBS LETT, V584, P1728, DOI 10.1016/j.febslet.2010.02.026
   Steen E, 2005, J ALZHEIMERS DIS, V7, P63, DOI 10.3233/jad-2005-7107
   Sugiura M, 2002, J BIOL CHEM, V277, P23294, DOI 10.1074/jbc.M201535200
   Summers SA, 1998, MOL CELL BIOL, V18, P5457, DOI 10.1128/MCB.18.9.5457
   Sun Y, 2003, J BIOL CHEM, V278, P27688, DOI 10.1074/jbc.M300760200
   Tafesse FG, 2006, J BIOL CHEM, V281, P29421, DOI 10.1074/jbc.R600021200
   Tamboli IY, 2010, J BIOL CHEM, V285, P37405, DOI 10.1074/jbc.M110.149468
   Trajkovic K, 2008, SCIENCE, V319, P1244, DOI 10.1126/science.1153124
   Urakawa H, 2003, J CLIN ENDOCR METAB, V88, P4673, DOI 10.1210/jc.2003-030202
   van Echten-Deckert G, 2012, PROG LIPID RES, V51, P378, DOI 10.1016/j.plipres.2012.07.001
   Vetrivel KS, 2005, J BIOL CHEM, V280, P25892, DOI 10.1074/jbc.M503570200
   Vetrivel KS, 2009, J BIOL CHEM, V284, P3793, DOI 10.1074/jbc.M808920200
   Vickers MH, 2012, FRONT PHYSIOL, V3, DOI 10.3389/fphys.2012.00242
   Vingtdeux V, 2007, J BIOL CHEM, V282, P18197, DOI 10.1074/jbc.M609475200
   Vucenik I, 2012, ANN NY ACAD SCI, V1271, P37, DOI 10.1111/j.1749-6632.2012.06750.x
   Wang GH, 2012, J BIOL CHEM, V287, P21384, DOI 10.1074/jbc.M112.340513
   Wang YZ, 2000, TRAFFIC, V1, P952, DOI 10.1034/j.1600-0854.2000.011205.x
   Yamaoka S, 2004, J BIOL CHEM, V279, P18688, DOI 10.1074/jbc.M401205200
   YANAGISAWA K, 1995, NAT MED, V1, P1062, DOI 10.1038/nm1095-1062
   Yuyama K, 2012, J BIOL CHEM, V287, P10977, DOI 10.1074/jbc.M111.324616
NR 82
TC 58
Z9 66
U1 1
U2 45
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1388-1981
EI 0006-3002
J9 BBA-MOL CELL BIOL L
JI Biochim. Biophys. Acta Mol. Cell Biol. Lipids
PD MAY
PY 2014
VL 1841
IS 5
SI SI
BP 793
EP 798
DI 10.1016/j.bbalip.2013.08.002
PG 6
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA AG8ZC
UT WOS:000335706400017
PM 23948264
DA 2025-06-11
ER

PT J
AU Boullu-Ciocca, S
   Dutour, A
   Guillaume, V
   Achard, V
   Oliver, C
   Grino, M
AF Boullu-Ciocca, S
   Dutour, A
   Guillaume, V
   Achard, V
   Oliver, C
   Grino, M
TI Postnatal diet-induced obesity in rats upregulates systemic and adipose
   tissue glucocorticoid metabolism during development and in adulthood -
   Its relationship with the metabolic syndrome
SO DIABETES
LA English
DT Article
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; PARAVENTRICULAR
   HYPOTHALAMIC NUCLEUS; BRAIN CORTICOSTEROID RECEPTORS;
   PITUITARY-ADRENAL-FUNCTION; OVERFED WEANLING RATS; IN-SITU
   HYBRIDIZATION; MESSENGER-RNA; SELECTIVE-INHIBITION; HYPERGLYCEMIC MICE;
   INSULIN-RESISTANCE
AB In humans, a hyperactivity of glucocorticoid metabolism was postulated to be involved in the intrauterine programming of the metabolic syndrome in adulthood. We studied in rats the effects of overfeeding, obtained by reducing the size of the litter in the immediate postnatal period, a time crucial for neuroendocrine maturation such as late gestation in humans. Overfeeding induced early-onset obesity and accelerated the maturation of the hypothalamo-pituitary-adrenal (HPA) axis together with an upregulation of adipose tissue glucocorticoid receptor (GR) mRNA. In adulthood, neonatally overfed rats presented with moderate increases in basal and stress-induced corticosterone secretion and striking changes in visceral adipose tissue glucocorticoid signaling, that is, enhanced GR and 11beta-hydroxysteroid dehydrogenate type 1 mRNA levels. The above-mentioned alterations in the endocrine status of overfed rats were accompanied by a moderate overweight status and significant metabolic disturbances comparable to those described in the metabolic syndrome. Our data demonstrate for the first time that postnatal overfeeding accelerates the maturation of the HPA axis and leads to permanent upregulation of the HPA axis and increased adipose tissue glucocorticoid sensitivity. Thus, the experimental paradigm of postnatal overfeeding is a powerful tool to understand the pathophysiology of glucocorticoid-induced programming of metabolic axes.
C1 Univ Mediterranee, Fac Med, INSERM, UMR 626,Hematol Lab, F-13385 Marseille 5, France.
   N Hosp, Endocrinol & Nutr Unit, Marseille, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Aix-Marseille Universite; Aix-Marseille Universite; Assistance
   Publique-Hopitaux de Marseille
RP Univ Mediterranee, Fac Med, INSERM, UMR 626,Hematol Lab, 27 Bd Jean Moulin, F-13385 Marseille 5, France.
EM michel.grino@medecine.univ-mrs.fr
RI Grino, Michel/O-5361-2017; Dutour, Anne/AAK-4460-2020
OI Dutour, Anne/0000-0002-5844-5884
CR Ahren B, 1997, AM J PHYSIOL-REG I, V273, pR113, DOI 10.1152/ajpregu.1997.273.1.R113
   Alberts P, 2003, ENDOCRINOLOGY, V144, P4755, DOI 10.1210/en.2003-0344
   Alberts P, 2002, DIABETOLOGIA, V45, P1528, DOI 10.1007/s00125-002-0959-6
   Andrew R, 1998, J CLIN ENDOCR METAB, V83, P1806, DOI 10.1210/jc.83.5.1806
   Björntorp P, 2000, NUTRITION, V16, P924, DOI 10.1016/S0899-9007(00)00422-6
   Bolt RJ, 2002, J CLIN ENDOCR METAB, V87, P1194, DOI 10.1210/jc.87.3.1194
   Boullu-Ciocca S, 2003, OBES RES, V11, P925, DOI 10.1038/oby.2003.127
   Catalani A, 2000, NEUROSCIENCE, V100, P319, DOI 10.1016/S0306-4522(00)00277-3
   Cleasby ME, 2003, ENDOCRINOLOGY, V144, P999, DOI 10.1210/en.2002-220559
   CONTEDEVOLX B, 1982, ENDOCRINOLOGY, V110, P2097, DOI 10.1210/endo-110-6-2097
   Grino M, 1998, J HISTOCHEM CYTOCHEM, V46, P753, DOI 10.1177/002215549804600608
   GRINO M, 1989, ENDOCRINOLOGY, V124, P2686, DOI 10.1210/endo-124-6-2686
   Jessop DS, 2001, J CLIN ENDOCR METAB, V86, P4109, DOI 10.1210/jc.86.9.4109
   Kotelevtsev Y, 1997, P NATL ACAD SCI USA, V94, P14924, DOI 10.1073/pnas.94.26.14924
   LACROIX O, 2002, 9 INT C OB SAO PAUL
   Lesage J, 2001, ENDOCRINOLOGY, V142, P1692, DOI 10.1210/en.142.5.1692
   Lindsay RS, 2003, J CLIN ENDOCR METAB, V88, P2738, DOI 10.1210/jc.2002-030017
   MACHO L, 1975, PHYSIOL BOHEMOSLOV, V24, P501
   MACHO L, 1982, ENDOKRINOLOGIE, V79, P65
   Masuzaki H, 2003, J CLIN INVEST, V112, P83, DOI [10.1172/JCI200317845, 10.1172/JCI17845]
   Masuzaki H, 2001, SCIENCE, V294, P2166, DOI 10.1126/science.1066285
   Matthews SG, 2002, TRENDS ENDOCRIN MET, V13, P373, DOI 10.1016/S1043-2760(02)00690-2
   McCormick JA, 2000, MOL ENDOCRINOL, V14, P506, DOI 10.1210/me.14.4.506
   Meaney MJ, 2001, ANNU REV NEUROSCI, V24, P1161, DOI 10.1146/annurev.neuro.24.1.1161
   Morton NM, 2004, DIABETES, V53, P931, DOI 10.2337/diabetes.53.4.931
   Nyirenda MJ, 1998, J CLIN INVEST, V101, P2174, DOI 10.1172/JCI1567
   Ordyan NE, 2001, STEROIDS, V66, P883, DOI 10.1016/S0039-128X(01)00123-4
   Paulmyer-Lacroix O, 2002, J CLIN ENDOCR METAB, V87, P2701, DOI 10.1210/jc.87.6.2701
   Phillips DIW, 1998, J CLIN ENDOCR METAB, V83, P757, DOI 10.1210/jc.83.3.757
   Plagemann A, 1999, BRAIN RES, V836, P146, DOI 10.1016/S0006-8993(99)01662-5
   Plagemann A, 1999, BRAIN RES, V818, P160, DOI 10.1016/S0006-8993(98)01264-5
   Plagemann A, 1998, NEUROSCI LETT, V258, P13, DOI 10.1016/S0304-3940(98)00823-4
   Proulx K, 2001, ENDOCRINOLOGY, V142, P4607, DOI 10.1210/en.142.11.4607
   Rask E, 2002, J CLIN ENDOCR METAB, V87, P3330, DOI 10.1210/jc.87.7.3330
   Rosmond R, 1998, J CLIN ENDOCR METAB, V83, P1853, DOI 10.1210/jc.83.6.1853
   Sainsbury A, 1997, DIABETES, V46, P209, DOI 10.2337/diabetes.46.2.209
   SCHMIDT TJ, 1994, RECEPTOR, V4, P229
   Shanks N, 2000, P NATL ACAD SCI USA, V97, P5645, DOI 10.1073/pnas.090571897
   SILVERMAN BL, 1991, DIABETES S2, V140, P121
   Slieker LJ, 1996, J BIOL CHEM, V271, P5301, DOI 10.1074/jbc.271.10.5301
   Tannenbaum BM, 1997, AM J PHYSIOL-ENDOC M, V273, pE1168, DOI 10.1152/ajpendo.1997.273.6.E1168
   Wake DJ, 2004, MOL CELL ENDOCRINOL, V215, P45, DOI 10.1016/j.mce.2003.11.015
   Wake DJ, 2003, J CLIN ENDOCR METAB, V88, P3983, DOI 10.1210/jc.2003-030286
   Wisialowski T, 2000, J CLIN INVEST, V105, P1253, DOI 10.1172/JCI8695
   Yajnik CS, 2004, J NUTR, V134, P205, DOI 10.1093/jn/134.1.205
   Zakrzewska KE, 1997, DIABETES, V46, P717, DOI 10.2337/diabetes.46.4.717
NR 46
TC 157
Z9 173
U1 0
U2 9
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD JAN
PY 2005
VL 54
IS 1
BP 197
EP 203
DI 10.2337/diabetes.54.1.197
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 886SA
UT WOS:000226247500026
PM 15616029
OA Bronze
DA 2025-06-11
ER

PT J
AU Chen, LR
   Chen, Y
   Wang, B
   Yang, ZC
   Cai, ZY
   Wang, XK
   Sun, LD
   Li, Z
   Wang, GJ
AF Chen, Lianru
   Chen, Ya
   Wang, Bin
   Yang, Zhongcheng
   Cai, Zongyu
   Wang, Xuekun
   Sun, Lidan
   Li, Zheng
   Wang, Guangji
TI Design, synthesis, and biological evaluation of deuterated
   indolepropionic acid derivatives as novel long-acting pan PPARα/γ/δ
   agonists
SO BIOORGANIC & MEDICINAL CHEMISTRY
LA English
DT Article
DE Deuteration; Metabolic syndrome; PPAR pan-agonist; Hyperlipidemia; NASH
ID LIVER; GAMMA; PATHOGENESIS; ACTIVATION; DISCOVERY; LIGANDS; MODELS;
   POTENT; ALPHA
AB Metabolic syndrome is a complex disease with diverse symptoms, but current pharmacological interventions have limited efficacy. Indeglitazar, a pan-agonist targeting the three-peroxisome proliferator activated receptors (PPAR), exhibits significant therapeutic effects on both diabetic and fatty liver animal models. However, its short half-life limits the in vivo efficacy, which might be attributed to the beta-oxidation of indolepropionic acid at Indeglitazar. To overcome this metabolic instability, two deuterium atoms were introduced to the alpha-position of indolepropionic acid to block the beta-oxidation. In this study, several deuterated derivatives were found to sustain PPARs activity and extend the half-life of liver microsomes. In oral glucose tolerance tests, I-1 exhibited the strongest glucose-lowering effect on ob/ob mice in this series. In db/db mice, I-1 reduced lipid levels, liver steatosis and promoted UCP1 expression in white adipose tissue. Mechanistic studies further revealed that I-1 exerts stronger effects than Indeglitazar on the regulation of genes related to lipid metabolism, mitochondrial function, and oxidative stress. Furthermore, I-1 significantly reduced liver steatosis, hepatocellular ballooning, inflammation, and fibrosis in NASH model induced by HFD + CCl4, and even exerted better therapeutic effect than that of Indeglitazar. With the above attractive efficacy, deuterated derivative I-1 is considered as a promising treatment for metabolic syndrome.
C1 [Chen, Lianru; Chen, Ya; Wang, Bin; Yang, Zhongcheng; Cai, Zongyu; Li, Zheng; Wang, Guangji] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Peoples R China.
   [Sun, Lidan] Jiaxing Univ, Coll Med, Dept Pharmaceut, Jiaxing Key Lab Photonanomedicine & Expt Therapeut, Jiaxing, Zhejiang, Peoples R China.
   [Chen, Lianru; Yang, Zhongcheng; Li, Zheng] Guangdong Pharmaceut Univ, Key Specialty Clin Pharm, Affiliated Hosp 1, Guangzhou 510006, Peoples R China.
   [Chen, Ya; Wang, Bin] Guangdong Pharmaceut Univ, Ctr Drug Res & Dev, Guangzhou 510006, Peoples R China.
   [Chen, Ya; Wang, Bin; Li, Zheng] Guangdong Pharmaceut Univ, Guangdong Prov Educ Dept, Key Lab New Drug Discovery & Evaluat, Guangzhou 510006, Peoples R China.
   [Cai, Zongyu; Li, Zheng] Guangdong Pharmaceut Univ, Guangzhou Key Lab Construct & Applicat New Drug Sc, Guangzhou 510006, Peoples R China.
   [Wang, Xuekun] Liaocheng Univ, Sch Pharmaceut Sci, Liaocheng 252059, Shandong, Peoples R China.
   [Li, Zheng] Guangdong Prov Key Lab New Drug Design & Evaluat, Guangzhou 510006, Peoples R China.
C3 Guangdong Pharmaceutical University; Jiaxing University; Guangdong
   Pharmaceutical University; Guangdong Pharmaceutical University;
   Guangdong Pharmaceutical University; Guangdong Pharmaceutical
   University; Liaocheng University
RP Li, Z; Wang, GJ (corresponding author), Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Peoples R China.; Sun, LD (corresponding author), Jiaxing Univ, Coll Med, Dept Pharmaceut, Jiaxing Key Lab Photonanomedicine & Expt Therapeut, Jiaxing, Zhejiang, Peoples R China.
EM slidan89@mail.zjxu.edu.cn; lizhengdrug@gdpu.edu.cn; gjwang@cpu.edu.cn
RI Zhang, Yi/KHW-2039-2024; bin, wang/X-9166-2019
FU Basic and Applied Basic Research of Guangzhou [202201010436]; National
   Key Clinical Specialty Construction Project (Clinical Pharmacy);
   Guangdong Provincial Key Laboratory of Construction Foundation
   [2020B1212060034]; Beijing Key Laboratory of Metabolic Disorder Related
   Cardiovascular Disease [DXWL-202304]; High-Level Clinical Key Specialty
   (Clinical Pharmacy) in Guangdong Province
FX This study was supported by Basic and Applied Basic Research of
   Guangzhou (202201010436) , National Key Clinical Specialty Construction
   Project (Clinical Pharmacy) , and High-Level Clinical Key Specialty
   (Clinical Pharmacy) in Guangdong Province, Guangdong Provincial Key
   Laboratory of Construction Foundation (2020B1212060034) , Beijing Key
   Laboratory of Metabolic Disorder Related Cardiovascular Disease
   (DXWL-202304) .
CR Adhikary T, 2015, NUCLEIC ACIDS RES, V43, P5033, DOI 10.1093/nar/gkv331
   Akoumianakis I, 2021, CURR ATHEROSCLER REP, V23, DOI 10.1007/s11883-021-00914-7
   Artis DR, 2009, P NATL ACAD SCI USA, V106, P262, DOI 10.1073/pnas.0811325106
   Blunder S, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22147354
   Cariou B, 2014, EXPERT OPIN INV DRUG, V23, P1441, DOI 10.1517/13543784.2014.954034
   Chang SH, 2019, OBES REV, V20, P241, DOI 10.1111/obr.12796
   Chen Z, 2020, FREE RADICAL BIO MED, V152, P116, DOI 10.1016/j.freeradbiomed.2020.02.025
   Chouchani ET, 2019, CELL METAB, V29, P27, DOI 10.1016/j.cmet.2018.11.002
   Derosa G, 2018, J CELL PHYSIOL, V233, P153, DOI 10.1002/jcp.25804
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Francque SM, 2021, NEW ENGL J MED, V385, P1547, DOI 10.1056/NEJMoa2036205
   Harrison SA, 2021, HEPATOL COMMUN, V5, P573, DOI 10.1002/hep4.1657
   Hong F, 2019, MOLECULES, V24, DOI 10.3390/molecules24142545
   Howland RH, 2015, J PSYCHOSOC NURS MEN, V53, P13, DOI 10.3928/02793695-20150821-55
   Huang DQ, 2023, GASTROENTEROLOGY, V165, DOI 10.1053/j.gastro.2023.04.025
   Imajo K, 2013, INT J MOL SCI, V14, P21833, DOI 10.3390/ijms141121833
   Kannt A, 2021, BRIT J PHARMACOL, V178, P2412, DOI 10.1111/bph.15427
   Kim JJP, 2002, CURR OPIN STRUC BIOL, V12, P721, DOI 10.1016/S0959-440X(02)00390-1
   King A, 2016, BIOCHEM PHARMACOL, V99, P1, DOI 10.1016/j.bcp.2015.08.108
   Lehrke M, 2005, CELL, V123, P993, DOI 10.1016/j.cell.2005.11.026
   Li Z, 2019, EUR J MED CHEM, V164, P352, DOI 10.1016/j.ejmech.2018.12.069
   Li Z, 2018, EUR J MED CHEM, V159, P267, DOI 10.1016/j.ejmech.2018.09.071
   Li Z, 2018, BIOORG CHEM, V76, P303, DOI 10.1016/j.bioorg.2017.12.012
   Magadum A, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19072013
   Matin A, 2009, J MED CHEM, V52, P6835, DOI 10.1021/jm900964r
   Montagner A, 2016, GUT, V65, P1202, DOI 10.1136/gutjnl-2015-310798
   Moreno-Fernández S, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101502
   Moseti D, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17010124
   Mutlib AE, 2008, CHEM RES TOXICOL, V21, P1672, DOI 10.1021/tx800139z
   Negoro N, 2012, J MED CHEM, V55, P1538, DOI 10.1021/jm2012968
   Nelson SD, 2003, DRUG METAB DISPOS, V31, P1481, DOI 10.1124/dmd.31.12.1481
   Pai Vikas, 2014, J Diabetes Sci Technol, V8, P132
   Poulsen LL, 2012, SEMIN CELL DEV BIOL, V23, P631, DOI 10.1016/j.semcdb.2012.01.003
   Ramachandran U, 2006, MINI-REV MED CHEM, V6, P563, DOI 10.2174/138955706776876140
   Régnier M, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-63579-3
   Rocchi S, 2001, MOL CELL, V8, P737, DOI 10.1016/S1097-2765(01)00353-7
   Sasaki S, 2011, J MED CHEM, V54, P1365, DOI 10.1021/jm101405t
   Shen P, 2006, J NUTR, V136, P899, DOI 10.1093/jn/136.4.899
   Suriano F, 2021, MICROBIOME, V9, DOI 10.1186/s40168-021-01097-8
   Trak-Smayra V, 2011, INT J EXP PATHOL, V92, P413, DOI 10.1111/j.1365-2613.2011.00793.x
   Van Meeteren MJW, 2020, EXPERT OPIN INV DRUG, V29, P117, DOI 10.1080/13543784.2020.1668375
   Zou HY, 2023, PHYTOMEDICINE, V116, DOI 10.1016/j.phymed.2023.154904
NR 43
TC 0
Z9 0
U1 3
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0968-0896
EI 1464-3391
J9 BIOORGAN MED CHEM
JI Bioorg. Med. Chem.
PD DEC 15
PY 2023
VL 96
AR 117533
DI 10.1016/j.bmc.2023.117533
EA NOV 2023
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry,
   Organic
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
GA Z7FL8
UT WOS:001113693800001
PM 37976807
DA 2025-06-11
ER

PT J
AU Souza, APD
   Barros, WMA
   Silva, JML
   Silva, MRM
   Silva, ABJ
   Fernandes, MSD
   dos Santos, MERA
   da Silva, ML
   do Carmo, TS
   Silva, RKP
   da Silva, KG
   de Souza, SL
   Souza, VDN
AF Souza, Ana Patricia da Silva
   Barros, Waleska Maria Almeida
   Silva, Jose Mauricio Lucas
   Silva, Mariluce Rodrigues Marques
   Silva, Ana Beatriz Januario
   Fernandes, Matheus Santos de Sousa
   dos Santos, Maria Eduarda Rodrigues Alves
   da Silva, Mayara Luclecia
   do Carmo, Taciane Silva
   Silva, Roberta Karlize Pereira
   da Silva, Karollainy Gomes
   de Souza, Sandra Lopes
   Souza, Viviane de Oliveira Nogueira
TI Effect of Metabolic Syndrome on Parkinson's Disease: A Systematic Review
SO CLINICS
LA English
DT Review
DE Metabolic Syndrome; Parkinson Disease; Vascular Risk Factors
ID GAMMA-GLUTAMYL-TRANSFERASE; RISK-FACTORS; ASSOCIATION; COMPONENTS;
   FALLS; MEN
AB Evidence shows that metabolic syndrome (MS) is associated with a greater risk of developing Parkinson's disease (PD) because of the increase in oxidative stress levels along with other factors such as neuroinflammation and mitochondrial dysfunction. However, because some studies have reported that MS is associated with a lower risk of PD, the relationship between MS and PD should be investigated. This study aimed to investigate the effect of MS on PD. Two authors searched five electronic databases, namely, MEDLINE, PubMed, Scopus, PsycINFO, Web of Science, and Science Direct, for relevant articles between September and October 2020. After screening the title and abstract of all articles, 34 articles were selected for full-text review. Finally, 11 articles meeting the eligibility criteria were included in the study. The quality of articles was critically evaluated using the Joanna Briggs Institute. Overall, we evaluated data from 23,586,349 individuals (including healthy individuals, with MS and PD) aged 30 years or more. In cohort studies, the follow-up period varied between 2 and 30 years. MS contributed considerably to the increase in the incidence of PD. In addition, obesity, a component of MS, alone can increase the probability of developing neurodegenerative diseases. However, despite few studies on MS and PD, changes in cognitive function and more rapid progression of PD disease has been documented in patients with MS using methods commonly used in research.
C1 [Souza, Ana Patricia da Silva; Barros, Waleska Maria Almeida; Silva, Mariluce Rodrigues Marques; Silva, Ana Beatriz Januario; Fernandes, Matheus Santos de Sousa; de Souza, Sandra Lopes] Univ Fed Pernambuco, Ctr Ciencias Saude, Programa Posgrad Neuropsiquiatria & Ciencias Comp, Recife, PE, Brazil.
   [Barros, Waleska Maria Almeida; Silva, Jose Mauricio Lucas; dos Santos, Maria Eduarda Rodrigues Alves; da Silva, Mayara Luclecia; do Carmo, Taciane Silva] Ctr Univ Osman Lins UNIFACOL, Ctr Ciencias Saude, Dept Fisioterapia, Vitoria De Santo Antao, PE, Brazil.
   [Barros, Waleska Maria Almeida; Silva, Roberta Karlize Pereira; da Silva, Karollainy Gomes] Ctr Univ Osman Lins UNIFACOL, Ctr Integrado Tecnol Neurociencia CITENC, Vitoria De Santo Antao, PE, Brazil.
   [Souza, Viviane de Oliveira Nogueira] Univ Fed Pernambuco, Ctr Acad Vitoria CAV, Nucl Nutr, Vitoria De Santo Antao, PE, Brazil.
C3 Universidade Federal de Pernambuco; Universidade Federal de Pernambuco
RP Souza, APD (corresponding author), Univ Fed Pernambuco, Ctr Ciencias Saude, Programa Posgrad Neuropsiquiatria & Ciencias Comp, Recife, PE, Brazil.
EM patricia-asb@hotmail.com
RI Souza, Ana/KFB-3039-2024; Fernandes, Matheus/AAI-4950-2020; souza,
   sandra/ABC-4504-2021; Barros, Waleska/AAP-6244-2021
OI Luclecia, Mayara/0000-0002-0686-2635; Silva,
   Roberta/0000-0002-8662-6324; Rodrigues alves dos Santos, Maria
   Eduarda/0000-0001-8546-7280; Mauricio, Jose/0000-0002-4508-3589; Santos
   de Sousa Fernandes, Matheus/0000-0002-1066-9176; , Ana
   Beatriz/0000-0001-7919-647X; Lopes de souza, sandra/0000-0003-4562-6042
CR Davis JW, 1996, AM J EPIDEMIOL, V144, P480, DOI 10.1093/oxfordjournals.aje.a008954
   De Pablo-Fernández E, 2017, J NEUROL NEUROSUR PS, V88, P176, DOI 10.1136/jnnp-2016-314601
   Doiron M, 2018, INT J GERIATR PSYCH, V33, P288, DOI 10.1002/gps.4735
   Goetz CG, 2008, MOVEMENT DISORD, V23, P2129, DOI 10.1002/mds.22340
   He RC, 2018, FRONT AGING NEUROSCI, V10, DOI 10.3389/fnagi.2018.00305
   Kao YC, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21010207
   Laudisio A, 2017, CLIN NUTR, V36, P559, DOI 10.1016/j.clnu.2016.02.004
   Lee A, 2016, NEUROL CLIN, V34, P955, DOI 10.1016/j.ncl.2016.06.012
   Lee DS, 2007, ARTERIOSCL THROM VAS, V27, P127, DOI 10.1161/01.ATV.0000251993.20372.40
   Leehey M, 2017, NEUROLOGY, V89, P1789, DOI 10.1212/WNL.0000000000004572
   Liu YH, 2021, J PARKINSON DIS, V11, P337, DOI 10.3233/JPD-202290
   Mahlknecht P, 2015, J PARKINSON DIS, V5, P681, DOI 10.3233/JPD-150685
   Meisinger C, 2005, J INTERN MED, V258, P527, DOI 10.1111/j.1365-2796.2005.01572.x
   das Merces MC, 2021, ARCH ENVIRON OCCUP H, V76, P266, DOI 10.1080/19338244.2020.1819186
   Morrell JS, 2012, J AM COLL HEALTH, V60, P82, DOI 10.1080/07448481.2011.582208
   Nam GE, 2018, PLOS MED, V15, DOI 10.1371/journal.pmed.1002640
   Oxenkrug G., 2017, Endocrinol Diabetes Metab J, V1
   Pelicioni PHS, 2021, BRAZ J PHYS THER, V25, P437, DOI 10.1016/j.bjpt.2020.11.005
   Peng ZY, 2018, PARKINSONISM RELAT D, V55, P68, DOI 10.1016/j.parkreldis.2018.05.013
   Poewe W, 2017, NAT REV DIS PRIMERS, V3, DOI 10.1038/nrdp.2017.13
   Postuma RB, 2016, NAT REV NEUROL, V12, P622, DOI 10.1038/nrneurol.2016.152
   Roh JH, 2021, METAB SYNDR RELAT D, V19, P1, DOI 10.1089/met.2020.0060
   Sääksjärvi K, 2015, PARKINSONISM RELAT D, V21, P1148, DOI 10.1016/j.parkreldis.2015.07.017
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Seppi K, 2019, MOVEMENT DISORD, V34, P180, DOI 10.1002/mds.27602
   Smith A., 1973, Symbol Digit Modalities Test
   Thaler A, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-66319-9
   van den Heuvel LL, 2020, PSYCHONEUROENDOCRINO, V117, DOI 10.1016/j.psyneuen.2020.104704
   Wang GJ, 2001, LANCET, V357, P354, DOI 10.1016/S0140-6736(00)03643-6
   Yadav UCS, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/9137629
   Yahia N, 2017, J COMMUN HEALTH, V42, P674, DOI 10.1007/s10900-016-0304-5
   Yoo D, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-58306-x
NR 32
TC 5
Z9 5
U1 0
U2 5
PU ELSEVIER ESPANA
PI MADRID
PA CALLE DE ZURBANO, 76-4TH FLR LEFT, MADRID, 28010, SPAIN
SN 1807-5932
EI 1980-5322
J9 CLINICS
JI Clinics
PY 2021
VL 76
AR e3379
DI 10.6061/clinics/2021/e3379
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA YI9ZI
UT WOS:000744198700002
PM 34909941
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tkachenko, OY
   Shayakhmetova, GM
   Matvienko, AV
   Kovalenko, VM
AF Tkachenko, Oleksandr Y.
   Shayakhmetova, Ganna M.
   Matvienko, Anatoliy, V
   Kovalenko, Valentina M.
TI Reproductive disorders in male rats induced by high-fructose consumption
   from juvenile age to puberty
SO ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE
   AND TOXICOLOGY
LA English
DT Article
DE epididymis; fertility; FSH; LH; male reproductive function; metabolic
   syndrome; MetS; sperm count; testes; testosterone
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; ADOLESCENTS;
   INFERTILITY; OBESITY
AB There is compelling evidence that a hypercaloric, high-fructose diet can cause metabolic syndrome (MetS) and a whole range of other metabolic changes. In the context of androgen deficiency, MetS in boys merits special attention, but the effects of fructose-rich diet in youth on future male reproductive function are still poorly evidenced. The aim of this study was to address this issue and analyse the effects of high-fructose intake starting from weaning to puberty (postnatal day 23 up to 83) on the reproductive function of male rats. For this purpose juvenile male Wistar rats were divided in two groups: control and the group receiving 10 % fructose solution instead of drinking water. Reproductive function was evaluated in terms of fertility, sperm count, testes/epididymis morphology, and serum sex hormones. The fructose-treated group showed a decrease in testosterone and twofold increase in luteinising and follicle-stimulating hormone levels in the serum. This was accompanied with lower testis/epididymis weights, sperm count, and changed testis/epididymis morphology. Their fertility remained unchanged, but the fertility of females mating with these males diminished. In addition, pre-implantation and post-implantation embryonic death rate rose in these females. Our results have confirmed that high fructose consumption from early age until puberty can impair the reproductive function of male rats, and call for further animal and epidemiological investigation.
C1 [Tkachenko, Oleksandr Y.; Shayakhmetova, Ganna M.; Matvienko, Anatoliy, V; Kovalenko, Valentina M.] NAMS Ukraine, Inst Pharmacol & Toxicol, Toxicol Dept, Kiev, Ukraine.
C3 National Academy of Medical Sciences of Ukraine; Institute of
   Pharmacology & Toxicology of the National Academy of Medical Sciences of
   Ukraine
RP Shayakhmetova, GM (corresponding author), NAMS Ukraine, Inst Pharmacol & Toxicol, Toxicol Dept, Kiev, Ukraine.
EM anna_shayakhmetova@yahoo.com
RI Shayakhmetova, Ganna/AAU-2814-2020
OI Tkachenko, Oleksandr/0000-0003-0622-5617; Shayakhmetova,
   Ganna/0000-0002-6504-7067
CR Favareto APA, 2011, BASIC CLIN PHARMACOL, V109, P85, DOI 10.1111/j.1742-7843.2011.00688.x
   Aslankoc R, 2019, ANDROLOGIA, V51, DOI 10.1111/and.13327
   Bettaieb A, 2014, FREE RADICAL BIO MED, V72, P247, DOI 10.1016/j.freeradbiomed.2014.04.011
   Boekelheide K, 2005, CURRENT PROTOCOLS TO
   Caliceti C, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040395
   Carnegie Christina, 2004, Rev Urol, V6 Suppl 6, pS3
   Chitra KC, 2003, ASIAN J ANDROL, V5, P203
   Creasy DM., 2002, Curr Protoc Toxicol, DOI [10.1002/0471140856.tx1604s13, DOI 10.1002/0471140856.TX1604S13]
   Ding GL, 2015, ASIAN J ANDROL, V17, P948, DOI 10.4103/1008-682X.150844
   DiNicolantonio JJ, 2018, PROG CARDIOVASC DIS, V61, P3, DOI 10.1016/j.pcad.2017.12.001
   Dutta S, 2019, ARAB J UROL, V17, P87, DOI 10.1080/2090598X.2019.1599624
   Goran MI, 2001, DIABETES, V50, P2444, DOI 10.2337/diabetes.50.11.2444
   Hara H, 2018, NEPHROL DIAL TRAN S1, V33, pi368
   Harrell CS, 2015, PSYCHONEUROENDOCRINO, V62, P252, DOI 10.1016/j.psyneuen.2015.08.025
   He F, 2015, J CLIN DENSITOM, V18, P30, DOI 10.1016/j.jocd.2014.07.009
   Jones TH, 2010, TRENDS ENDOCRIN MET, V21, P496, DOI 10.1016/j.tem.2010.03.002
   Kempinas W.De Grava., 2015, Spermatogenesis, V4, pe979114, DOI 10.4161/21565562.2014.979114
   Khitan Z, 2013, J NUTR METAB, V2013, DOI 10.1155/2013/682673
   Lanaspa MA, 2012, J BIOL CHEM, V287, P40732, DOI 10.1074/jbc.M112.399899
   Landgraf K, 2015, DIABETES, V64, P1249, DOI 10.2337/db14-0744
   Lee JM, 2006, DIABETES CARE, V29, P2427, DOI 10.2337/dc06-0709
   Martins AD, 2019, WORLD J MENS HEALTH, V37, P113, DOI 10.5534/wjmh.180055
   Meydanli EG, 2018, ULTRASTRUCT PATHOL, V42, P65, DOI 10.1080/01913123.2017.1397075
   Miller A, 2008, CURR OPIN GASTROEN, V24, P204, DOI 10.1097/MOG.0b013e3282f3f4c4
   Moran A, 1999, DIABETES, V48, P2039, DOI 10.2337/diabetes.48.10.2039
   Morrison CD, 2015, BEST PRACT RES CL OB, V29, P507, DOI 10.1016/j.bpobgyn.2014.10.006
   Palmert MR, 2012, NEW ENGL J MED, V366, P443, DOI 10.1056/NEJMcp1109290
   Porto ML, 2015, TOXICOL IN VITRO, V29, P1977, DOI 10.1016/j.tiv.2015.08.006
   Prevot V, 2006, KNOBIL NEILLS PHYSL, P1395
   Rastrelli G, 2018, FRONT HORM RES, V49, P131, DOI 10.1159/000485999
   Salem HR, 2018, World Nutrition., V9, P284, DOI [10.26596/wn.201893284-291, DOI 10.26596/WN.201893284-291]
   Sock ETN, 2010, BRIT J NUTR, V103, P939, DOI 10.1017/S0007114509992819
   Tappy L, 2010, NUTRITION, V26, P1044, DOI 10.1016/j.nut.2010.02.014
   Taskinen MR, 2019, NUTRIENTS, V11, DOI 10.3390/nu11091987
   Toop CR, 2016, NUTRIENTS, V8, DOI 10.3390/nu8090577
   Tyl Rochelle W, 2002, Curr Protoc Toxicol, VChapter 16, DOI 10.1002/0471140856.tx1601s11
   Väistö J, 2014, INT J BEHAV NUTR PHY, V11, DOI 10.1186/1479-5868-11-55
   Vona R, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8267234
   Wagner H, 2018, ARAB J UROL, V16, P35, DOI 10.1016/j.aju.2017.11.001
   Walvoord EC, 2010, J ADOLESCENT HEALTH, V47, P433, DOI 10.1016/j.jadohealth.2010.05.018
   Wang DD, 2012, J NUTR, V142, P916, DOI 10.3945/jn.111.151951
   Wittcopp C, 2016, PEDIATR REV, V37, P193, DOI [10.1542/pir.2014-0095, 10.1159/000449268]
   Yamazaki M, 2016, LIFE SCI, V149, P146, DOI 10.1016/j.lfs.2016.02.020
   Zawatski W, 2013, J ENDOCRINOL, V218, pR1, DOI 10.1530/JOE-12-0449
NR 44
TC 5
Z9 5
U1 0
U2 6
PU INST MEDICAL RESEARCH & OCCUPATIONAL HEALTH
PI ZAGREB
PA 2 KSAVERSKA ST P O BOX 291, ZAGREB, 00000, CROATIA
SN 0004-1254
EI 1848-6312
J9 ARH HIG RADA TOKSIKO
JI Arh. Hig. Rada. Toksikol.
PD MAR
PY 2020
VL 71
IS 1
BP 78
EP 86
DI 10.2478/aiht-2020-71-3303
PG 9
WC Public, Environmental & Occupational Health; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Toxicology
GA LC5DT
UT WOS:000525345900009
PM 32597133
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bautista, RJH
   Mahmoud, AM
   Königsberg, M
   Guerrero, NELD
AF Hernandez Bautista, Rene J.
   Mahmoud, Ayman M.
   Konigsberg, Mina
   Diaz Guerrero, Norma E. Lopez
TI Obesity: Pathophysiology, monosodium glutamate-induced model and
   anti-obesity medicinal plants
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Obesity; Monosodium glutamate; Oxidative stress; Inflammation; Arcuate
   nucleous; Medicinal plants
ID PANCREATIC BETA-CELLS; FREE FATTY-ACIDS; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; METABOLIC SYNDROME; ADIPOSE-TISSUE; MOUSE MODEL; PPAR-GAMMA;
   NONALCOHOLIC STEATOHEPATITIS; INFLAMMATORY CYTOKINES
AB Obesity and overweight have increased at an alarming rate in the world during the last three decades. Obesity is a crucial factor in the development of metabolic abnormalities, including glucose intolerance, insulin resistance, metabolic syndrome, low-grade inflammation and oxidative stress. A similar scinario occurs during the aging process where alterations of the energetic metabolism homeostasis and a chronic systematic low-grade inflammation have been observed. Oxidative stress and poor physical performance can increase the risk of metabolic disease. Despite the diverse studies on the pathophysiological effects of obesity, its impact related to gender and through life, particularly during aging, hasn't received a reasonable attention. The purpose of this review is to outline the pathophysiological mechanisms and metabolic alterations associated with obesity, with an emphasis on the monosodium glutamate (MSG)-induced obese model. MSG-induced obesity associated inflammation and declined adiponectin were more obvious in male mice, while glucose tolerance, insulin sensitivity and the redox balance were altered with increased age of both male and female mice. These findings indicate that the metabolic alterations in MSG-induced obesity are associated with the gender as well as aging. Therefore, the MSG obesity model is of a resonable value to underlie the relationship between gender, aging and metabolic alterations in obesity. In addition, we reviewed the medicinal plants and their active constituents which have been used to treat MSG-induced obesity. Given the significat value of this model, studies are needed to scrutinize the benificial effects and underlying mechanisms of medicinal plants with proven anti-obesity activity.
C1 [Hernandez Bautista, Rene J.; Konigsberg, Mina; Diaz Guerrero, Norma E. Lopez] Metropolitan Autonomous Univ, Div Hlth & Biol Sci, Dept Hlth Sci, Lab Bioenerget & Cellular Aging, Prol Canal Miramontes 3855, Mexico City 14387, Cdmx, Mexico.
   [Mahmoud, Ayman M.] Beni Suef Univ, Physiol Div, Dept Zool, Fac Sci, Bani Suwayf, Egypt.
C3 Universidad Autonoma Metropolitana - Mexico; Egyptian Knowledge Bank
   (EKB); Beni Suef University
RP Bautista, RJH (corresponding author), Metropolitan Autonomous Univ, Div Hlth & Biol Sci, Dept Hlth Sci, Lab Bioenerget & Cellular Aging, Prol Canal Miramontes 3855, Mexico City 14387, Cdmx, Mexico.
EM rjhb11@xanum.uam.mx
RI Lopez-Diazguerrero, Norma/MSW-7061-2025; Mahmoud, Ayman/S-2613-2016
OI Hernandez Bautista, Rene Javier/0000-0001-7065-2862; LOPEZ DIAZ
   GUERRERO, NORMA EDITH/0000-0001-7470-9360; Mahmoud,
   Ayman/0000-0003-0279-6500
CR Abd El-Twab SM, 2016, CAN J PHYSIOL PHARM, V94, P651, DOI 10.1139/cjpp-2015-0503
   Aguilar MJ, 2013, J CLIN NURS, V22, P2002, DOI 10.1111/jocn.12034
   Aitlhadj L, 2011, ENVIRON HEALTH PERSP, V119, P20, DOI 10.1289/ehp.1002522
   Al-Rasheed N. M., 2017, SIMVASTATIN AMELIORA, V2017
   Alarcon-Aguilar FJ, 2008, EUR J PHARMACOL, V599, P152, DOI 10.1016/j.ejphar.2008.09.047
   Alarcon-Aguilar FJ, 2007, J ETHNOPHARMACOL, V114, P66, DOI 10.1016/j.jep.2007.07.020
   Albuquerque D, 2017, BRIT MED BULL, V123, P159, DOI 10.1093/bmb/ldx022
   Anavi S, 2014, FREE RADICAL BIO MED, V71, P61, DOI 10.1016/j.freeradbiomed.2014.03.007
   Andersson DP, 2016, J CLIN ENDOCR METAB, V101, P3765, DOI 10.1210/jc.2016-1883
   Andreazzi AE, 2009, J ENDOCRINOL, V201, P351, DOI 10.1677/JOE-08-0312
   Anstöter CS, 2016, J PHYS CHEM B, V120, P7108, DOI 10.1021/acs.jpcb.6b05271
   Antonopoulos AS, 2016, OBES REV, V17, P989, DOI 10.1111/obr.12440
   Antonopoulos A. S., 2017, CARDIOVASC RES
   Apovian CM, 2015, J CLIN ENDOCR METAB, V100, P342, DOI 10.1210/jc.2014-3415
   Araujo T. R., 2018, J CELL PHYSL
   Barbarash O, 2016, DIABETOL METAB SYNDR, V8, DOI 10.1186/s13098-016-0136-6
   Barth RF, 2017, CURR HYPERTENS REP, V19, DOI 10.1007/s11906-017-0753-y
   Bártíková H, 2017, POL J FOOD NUTR SCI, V67, P233, DOI 10.1515/pjfns-2017-0004
   Bentley AR, 2012, EUR RESPIR J, V39, P979, DOI 10.1183/09031936.00190010
   Bhandari U, 2018, ATHEROSCLEROSIS SUPP, V32, P138, DOI 10.1016/j.atherosclerosissup.2018.04.423
   Bianchi C, 2011, NUTR METAB CARDIOVAS, V21, P699, DOI 10.1016/j.numecd.2010.03.006
   Bloss EB, 2010, J NEUROSCI, V30, P6726, DOI 10.1523/JNEUROSCI.0759-10.2010
   Boonnate P, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0131595
   Bousová I, 2016, EUR J NUTR, V55, P361, DOI 10.1007/s00394-015-0856-7
   Brown LA, 2009, OBESITY, V17, P460, DOI 10.1038/oby.2008.590
   Brown-Borg HM, 2006, AGE, V28, P145, DOI 10.1007/s11357-006-9003-y
   Butani L, 2016, METAB SYNDR RELAT D, V14, P182, DOI 10.1089/met.2015.0161
   Caetano LC, 2017, EUR J NUTR, V56, P705, DOI 10.1007/s00394-015-1114-8
   Calabrese EJ, 2008, AGEING RES REV, V7, P8, DOI 10.1016/j.arr.2007.07.001
   Calabrese Edward J, 2003, Nonlinearity Biol Toxicol Med, V1, P455, DOI 10.1080/15401420390271056
   Calabrese EJ, 2002, HUM EXP TOXICOL, V21, P91, DOI 10.1191/0960327102ht217oa
   Calabrese V, 2011, MOL ASPECTS MED, V32, P279, DOI 10.1016/j.mam.2011.10.007
   Calabuig-Navarro V, 2015, J BIOL CHEM, V290, P15581, DOI 10.1074/jbc.M115.650994
   Calis IU, 2016, IRAN RED CRESCENT ME, V18, DOI 10.5812/ircmj.37912
   Cartier A, 2009, AM J CLIN NUTR, V89, P1307, DOI 10.3945/ajcn.2008.27030
   Castro AVB, 2014, ARQ BRAS ENDOCRINOL, V58, P600, DOI 10.1590/0004-2730000003223
   Cheng HL, 2018, J CLIN ENDOCR METAB, V103, P2851, DOI 10.1210/jc.2017-01825
   Cheung BMY, 2012, CURR ATHEROSCLER REP, V14, P160, DOI 10.1007/s11883-012-0227-2
   Cohen P, 2016, MOL BIOL CELL, V27, P2523, DOI 10.1091/mbc.E15-10-0749
   Collison KS, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-58
   Cornelius C, 2013, IMMUN AGEING, V10, DOI 10.1186/1742-4933-10-15
   CROSS CE, 1987, ANN INTERN MED, V107, P526, DOI 10.7326/0003-4819-107-4-526
   de Freitas LM, 2017, AM J TRANSL RES, V9, P2050
   de Kreutzenberg SV, 2010, DIABETES, V59, P1006, DOI 10.2337/db09-1187
   Dhana K, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0154273
   Dimova R, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/823481
   Dixit P, 2012, INDIAN J EXP BIOL, V50, P476
   Domijan AM, 2014, J CELL SCI, V127, P21, DOI 10.1242/jcs.138370
   Domínguez L, 2010, ARCH BIOCHEM BIOPHYS, V500, P82, DOI 10.1016/j.abb.2010.05.017
   Doo M., 2017, NUTRIENTS, V9
   Durak A, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0790-0
   Ellulu MS, 2017, ARCH MED SCI, V13, P851, DOI 10.5114/aoms.2016.58928
   Ertunc ME, 2016, J LIPID RES, V57, P2099, DOI 10.1194/jlr.R066514
   Farombi EO, 2006, HUM EXP TOXICOL, V25, P251, DOI 10.1191/0960327106ht621oa
   Fazakerley DJ, 2018, J BIOL CHEM, V293, P7315, DOI 10.1074/jbc.RA117.001254
   Feng RN, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0551-1
   Feng Y, 2019, J MATERN-FETAL NEO M, V32, P339, DOI 10.1080/14767058.2018.1446207
   Fingeret M, 2018, NUTR METAB CARDIOVAS, V28, P1036, DOI 10.1016/j.numecd.2018.06.011
   Fischer HJ, 2017, J IMMUNOL, V198, P1910, DOI 10.4049/jimmunol.1601011
   Foong K. W., 2017, POSTREPROD HLTH
   Fortis-Barrera A, 2017, CAN J PHYSIOL PHARM, V95, P170, DOI 10.1139/cjpp-2015-0475
   Friedman J, 2014, J ENDOCRINOL, V223, pT1, DOI 10.1530/JOE-14-0405
   Fujimoto M, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/892697
   Fujimoto M, 2012, DIGEST LIVER DIS, V44, P767, DOI 10.1016/j.dld.2012.02.002
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Fussenegger D, 2008, OBES REV, V9, P76, DOI 10.1111/j.1467-789X.2007.00405.x
   Gammelsaeter R, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0022960
   Gao H, 2014, CELL METAB, V19, P981, DOI 10.1016/j.cmet.2014.03.032
   Gao WQ, 2018, BIOMED PHARMACOTHER, V103, P637, DOI 10.1016/j.biopha.2018.04.043
   Garratt M, 2017, J GERONTOL A-BIOL, V72, P1620, DOI 10.1093/gerona/glx010
   Gathercole LL, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026223
   Generoso G, 2018, J CLIN LIPIDOL, V12, P1290, DOI 10.1016/j.jacl.2018.05.003
   Germoush MO, 2018, BIOMED PHARMACOTHER, V102, P392, DOI 10.1016/j.biopha.2018.03.104
   Gobato Amanda Oliva, 2014, Rev. paul. pediatr., V32, P55
   Guimaraes EDG, 2017, NUTR NEUROSCI, V20, P153, DOI 10.1179/1476830515Y.0000000004
   Guedes JAC, 2018, BONE, V115, P68, DOI 10.1016/j.bone.2017.11.020
   Guilherme A, 2018, MOL METAB, V16, P116, DOI 10.1016/j.molmet.2018.06.014
   Guo SX, 2015, INT J ENV RES PUB HE, V12, P6582, DOI 10.3390/ijerph120606582
   Haider A, 2014, INT J ENDOCRINOL, V2014, DOI 10.1155/2014/683515
   Hajek A, 2015, BMC GERIATR, V15, DOI 10.1186/s12877-015-0081-5
   Halliwell B, 1996, ANNU REV NUTR, V16, P33, DOI 10.1146/annurev.nu.16.070196.000341
   Halliwell B, 2012, NUTR REV, V70, P257, DOI 10.1111/j.1753-4887.2012.00476.x
   Han LN, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0834-1
   He LL, 2015, SPECTROCHIM ACTA A, V134, P361, DOI 10.1016/j.saa.2014.06.121
   Helms HC, 2012, GLIA, V60, P882, DOI 10.1002/glia.22321
   Hermes-Lima M., 2005, Oxygen in biology and biochemistry: Role of free radicals, P319, DOI DOI 10.1002/047167558X.CH12
   Hernández-Bautista RJ, 2014, INT J MOL SCI, V15, P11473, DOI 10.3390/ijms150711473
   Hocayen PDS, 2016, PHARM BIOL, V54, P1263, DOI 10.3109/13880209.2015.1067232
   Hoffmann GR, 2009, DOSE-RESPONSE, V7, P1, DOI 10.2203/dose-response.08-023.Hoffmann
   Honka MJ, 2018, EUR J ENDOCRINOL, V178, P523, DOI 10.1530/EJE-17-0882
   Hozayen WG, 2016, J INTERCULT ETHNOPHA, V5, P57, DOI 10.5455/jice.20151230055930
   Huang SMA, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006871
   Huh JY, 2017, DIABETES, V66, P835, DOI 10.2337/db16-1122
   Husarova V., 2013, JMED RES, V2013, P12
   Imbernon M, 2013, GASTROENTEROLOGY, V144, P636, DOI 10.1053/j.gastro.2012.10.051
   IOTF, 2008, WHAT WE DO POL PREV
   Jelenik T., 2014, DIABETES, V63
   Jin L, 2018, NEUROSCI LETT, V682, P39, DOI 10.1016/j.neulet.2018.06.008
   Jin YJ, 2015, NUTR NEUROSCI, V18, P376, DOI 10.1179/1476830515Y.0000000039
   Johansson ÅCM, 2016, ARTHRITIS RES THER, V18, DOI 10.1186/s13075-016-0994-1
   Jorgensen SB, 2013, DIABETES, V62, P56, DOI 10.2337/db12-0443
   Jou C, 2014, NEW ENGL J MED, V370, P1874, DOI 10.1056/NEJMp1400613
   Kang YE, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0154003
   Katsoulieris EN, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0158873
   Kim JW, 2018, J EXERC REHABIL, V14, P460, DOI 10.12965/jer.1836194.097
   Kim M, 2018, FREE RADICAL BIO MED, V124, P517, DOI 10.1016/j.freeradbiomed.2018.06.040
   Kim NH, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000003384
   Kondoh M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0080349
   Kotani K, 2012, AUSTRALAS J AGEING, V31, P124, DOI 10.1111/j.1741-6612.2011.00571.x
   Kovac S, 2015, BBA-GEN SUBJECTS, V1850, P794, DOI 10.1016/j.bbagen.2014.11.021
   Kubota T, 2011, CELL METAB, V13, P294, DOI 10.1016/j.cmet.2011.01.018
   Kumar B, 2015, INVEST OPHTH VIS SCI, V56, P2985, DOI 10.1167/iovs.15-16466
   Kumar P, 2016, DRUG RES, V66, P174, DOI 10.1055/s-0035-1555812
   Kume S, 2016, EBIOMEDICINE, V13, P168, DOI 10.1016/j.ebiom.2016.10.038
   Lanuza-Masdeu J, 2013, DIABETES, V62, P2308, DOI 10.2337/db12-1097
   Lazarevic G, 2006, DIABETES METAB, V32, P583, DOI 10.1016/S1262-3636(07)70312-9
   Lee J, 2016, ANALYST, V141, P847, DOI 10.1039/c5an01875g
   Lentferink YE, 2017, J OBES, V2017, DOI 10.1155/2017/3793868
   Leoni MC, 2010, PEDIATRIC REP, V2, P62, DOI 10.4081/pr.2010.e19
   Li MN, 2013, YONSEI MED J, V54, P283, DOI 10.3349/ymj.2013.54.2.283
   Li XX, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0182273
   Liang KW, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000012730
   Liang X, 2017, J FUNCT FOODS, V31, P89, DOI 10.1016/j.jff.2017.01.026
   Liu J, 2011, J CLIN ENDOCR METAB, V96, P438, DOI 10.1210/jc.2010-1174
   Liu YH, 2013, BIOCHEM BIOPH RES CO, V438, P78, DOI 10.1016/j.bbrc.2013.07.029
   Loh K, 2009, CELL METAB, V10, P260, DOI 10.1016/j.cmet.2009.08.009
   Luck H, 2015, CELL METAB, V21, P527, DOI 10.1016/j.cmet.2015.03.001
   Luna-López A, 2014, J CELL COMMUN SIGNAL, V8, P323, DOI 10.1007/s12079-014-0248-4
   Luna-López A, 2013, FREE RADICAL BIO MED, V63, P41, DOI 10.1016/j.freeradbiomed.2013.04.033
   Luna-López A, 2010, FREE RADICAL BIO MED, V49, P1192, DOI 10.1016/j.freeradbiomed.2010.07.004
   Ma Juan, 2007, Neurosci Bull, V23, P209, DOI 10.1007/s12264-007-0031-0
   Ma MF, 2018, MOL MED REP, V18, P807, DOI 10.3892/mmr.2018.9016
   Maciejczyk M, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/6940515
   Madhavadas S, 2015, INDIAN J PHARMACOL, V47, P39, DOI 10.4103/0253-7613.150327
   Mahmoud AM, 2017, FASEB J, V31, P4636, DOI 10.1096/fj.201601244RR
   Mahmoud AM, 2017, CHEM-BIOL INTERACT, V277, P146, DOI 10.1016/j.cbi.2017.09.015
   Mahmoud AM, 2017, BIOMED PHARMACOTHER, V94, P280, DOI 10.1016/j.biopha.2017.07.101
   Mahmoud AM, 2017, BIOMED PHARMACOTHER, V91, P303, DOI 10.1016/j.biopha.2017.04.073
   Mahmoud AM, 2017, CHEM-BIOL INTERACT, V270, P59, DOI 10.1016/j.cbi.2017.04.009
   Mahmoud AM, 2017, BBA-GEN SUBJECTS, V1861, P3311, DOI 10.1016/j.bbagen.2016.08.013
   Mahmoud AM, 2017, EUR J NUTR, V56, P1671, DOI 10.1007/s00394-016-1214-0
   Mahmoud AM, 2012, J DIABETES COMPLICAT, V26, P483, DOI 10.1016/j.jdiacomp.2012.06.001
   Mao K, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-04805-5
   Mariño G, 2010, P NATL ACAD SCI USA, V107, P16268, DOI 10.1073/pnas.1002696107
   Martin JM, 2016, INT J ENDOCRINOL, V2016, DOI 10.1155/2016/9242319
   Martos-Moreno GA, 2014, NUTR HOSP, V30, P787, DOI 10.3305/nh.2014.30.4.7661
   Mattos RT, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0168610
   Mauro CR, 2013, ANN VASC SURG, V27, P346, DOI 10.1016/j.avsg.2012.07.017
   McDonagh B, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00470
   Meldrum BS, 2000, J NUTR, V130, p1007S, DOI 10.1093/jn/130.4.1007S
   Miller NE, 2011, AM J PHYSIOL-ENDOC M, V301, pE659, DOI 10.1152/ajpendo.00058.2011
   Min JY, 2010, FEBS LETT, V584, P2427, DOI 10.1016/j.febslet.2010.04.048
   Miranda RA, 2014, CELL PHYSIOL BIOCHEM, V33, P1075, DOI 10.1159/000358677
   Miyazaki T, 2016, ONCOTARGET, V7, P10448, DOI 10.18632/oncotarget.7249
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   Morelli NR, 2018, ARCH ENDOCRIN METAB, V62, P309, DOI 10.20945/2359-3997000000036
   Moreno-Franco B, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-28982-x
   Munoz M. T., 2011, Pediatria Integral, V15, P507
   Murakami S, 2006, EXP GERONTOL, V41, P1014, DOI 10.1016/j.exger.2006.06.061
   Nagata M, 2006, EXP ANIM TOKYO, V55, P109, DOI 10.1538/expanim.55.109
   Nascimento OV, 2013, AN ACAD BRAS CIENC, V85, P355, DOI 10.1590/S0001-37652013005000001
   Ni YC, 2009, GLIA, V57, P1296, DOI 10.1002/glia.20849
   Nickelson KJ, 2012, EXP DIABETES RES, DOI [10.1155/2012/859395, 10.1155/2012/849540]
   Nonhebel D.C., 1974, Free-Radical Chemistry; Structure and Mechanism
   Norseen J, 2012, MOL CELL BIOL, V32, P2010, DOI 10.1128/MCB.06193-11
   OLNEY JW, 1969, SCIENCE, V164, P719, DOI 10.1126/science.164.3880.719
   Osundiji MA, 2012, DIABETES, V61, P321, DOI 10.2337/db11-1050
   Panis C, 2014, ADV PROTEIN CHEM STR, V94, P19, DOI 10.1016/B978-0-12-800168-4.00002-0
   Panzhinskiy E, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0077228
   Paolini M, 2004, CARCINOGENESIS, V25, P61, DOI 10.1093/carcin/bgg174
   Parker L, 2016, FRONT PHYSIOL, V7, DOI 10.3389/fphys.2016.00411
   Patil S, 2011, INDIAN J PHARMACOL, V43, P644, DOI 10.4103/0253-7613.89818
   Paul MVS, 2012, TOXICOL MECH METHOD, V22, P625, DOI 10.3109/15376516.2012.714008
   Pelantová H, 2016, ANAL BIOANAL CHEM, V408, P567, DOI 10.1007/s00216-015-9133-0
   Penesova A, 2011, J HUM HYPERTENS, V25, P391, DOI 10.1038/jhh.2010.72
   Perry AC, 2014, HORM MOL BIOL CLIN I, V19, P151, DOI 10.1515/hmbci-2014-0004
   Price NL, 2018, CELL REP, V22, P2133, DOI 10.1016/j.celrep.2018.01.074
   Radak Z, 2017, REDOX BIOL, V12, P285, DOI 10.1016/j.redox.2017.02.015
   Rahal A, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/761264
   Rask-Madsen C, 2012, ARTERIOSCL THROM VAS, V32, P2052, DOI 10.1161/ATVBAHA.111.241919
   Ratz-Lyko A, 2015, PHYTOTHER RES, V29, P509, DOI 10.1002/ptr.5289
   Rendo-Urteaga T, 2018, J PEDIATR ENDOCR MET, V31, P1221, DOI 10.1515/jpem-2018-0120
   Ribeiro RA, 2013, MOL BIOL REP, V40, P4521, DOI 10.1007/s11033-013-2546-y
   Rimmele TS, 2017, CEREB CORTEX, V27, P3272, DOI 10.1093/cercor/bhx078
   Roberts D. D., 2017, ANTIOXID REDOX SIGNA
   Robinson M. M., 2014, J CLIN ENDOCRINOL ME, V99
   Rotondo F, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-09450-4
   Pinho CPS, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0178958
   Sanches JR, 2016, FRONT PHARMACOL, V7, DOI 10.3389/fphar.2016.00048
   Santos S, 2016, OBESITY, V24, P424, DOI 10.1002/oby.21343
   Sasaki-Hamada S, 2015, EUR J NEUROSCI, V41, P1393, DOI 10.1111/ejn.12891
   Schenk S, 2008, J CLIN INVEST, V118, P2992, DOI 10.1172/JCI34260
   Schrover IM, 2018, EUR J PREV CARDIOL, V25, P1548, DOI 10.1177/2047487318790722
   Schultz NS, 2014, DIABETES, V63, P111, DOI 10.2337/db13-0621
   Seiva FRF, 2012, FOOD CHEM TOXICOL, V50, P3556, DOI 10.1016/j.fct.2012.07.009
   Selovic A, 2016, J MATERN-FETAL NEO M, V29, P2131, DOI 10.3109/14767058.2015.1077220
   Sharma A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0116233
   Shen JZ, 2012, DIABETOLOGIA, V55, P1836, DOI 10.1007/s00125-012-2519-z
   Siegel G, 2014, ATHEROSCLEROSIS, V237, P584, DOI 10.1016/j.atherosclerosis.2014.10.023
   Sies H, 2015, REDOX BIOL, V4, P180, DOI 10.1016/j.redox.2015.01.002
   Sizemore ST, 2018, CELL RES, V28, P1090, DOI 10.1038/s41422-018-0086-7
   Song HJ, 2016, ASIA-PAC J PUBLIC HE, V28, P146, DOI 10.1177/1010539515626267
   Spijker HS, 2015, DIABETES, V64, P2928, DOI 10.2337/db14-1752
   Sulkowski G, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0113954
   Suneetha D., 2014, INT J PHARMACOGN PHY, V5, P267
   Supriya K., 2012, Research Journal of Pharmaceutical, Biological and Chemical Sciences, V3, P555
   Supriya R, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0201585
   Svart MV, 2017, DIABETOLOGIA, V60, P1197, DOI 10.1007/s00125-017-4271-x
   Taher J, 2014, MOL METAB, V3, P823, DOI 10.1016/j.molmet.2014.09.005
   TAKASAKI Y, 1978, TOXICOLOGY, V9, P293, DOI 10.1016/0300-483X(78)90013-6
   Templeman NM, 2017, CELL REP, V20, P451, DOI 10.1016/j.celrep.2017.06.048
   Titchenell PM, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8078
   Tomankova V, 2015, LIFE SCI, V133, P15, DOI 10.1016/j.lfs.2015.04.014
   Trouwborst I, 2018, FRONT NUTR, V5, DOI 10.3389/fnut.2018.00077
   Tu Q, 2018, TRIALS, V19, DOI 10.1186/s13063-018-2766-5
   Utzolino S, 2014, J CRIT CARE, V29, DOI 10.1016/j.jcrc.2014.05.026
   Valentijn TM, 2013, SURG-J R COLL SURG E, V11, P169, DOI 10.1016/j.surge.2013.02.003
   Weinberger M, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000748
   Weissmann L, 2014, DIABETES, V63, P3334, DOI 10.2337/db13-1817
   WHO, 2017, OB WEIGHT
   Willers SM, 2015, ANN NUTR METAB, V66, P63, DOI 10.1159/000369979
   Wolf D, 2017, THROMB HAEMOSTASIS, V117, P325, DOI 10.1160/TH16-07-0553
   Xu E, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms14803
   Xu J, 2013, PLANT PHYSIOL, V161, P1517, DOI 10.1104/pp.112.212803
   YAMAMOTO T, 1993, ENDOCR J, V40, P461, DOI 10.1507/endocrj.40.461
   Yan H, 2017, MOL MED REP, V15, P180, DOI 10.3892/mmr.2016.5966
   Yan M, 2016, MOL MED REP, V13, P2499, DOI 10.3892/mmr.2016.4819
   Yang L, 2010, COMP BIOCHEM PHYS C, V151, P204, DOI 10.1016/j.cbpc.2009.10.010
   Yanovski SZ, 2011, NEW ENGL J MED, V365, P2030, DOI 10.1056/NEJMe1111487
   Yi JS, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3354
   Youn JY, 2014, DIABETES, V63, P2344, DOI 10.2337/db13-0719
   Yulyaningsih E, 2017, CELL REP, V19, P2257, DOI 10.1016/j.celrep.2017.05.060
   Zhang J, 2017, EMBO J, V36, P1302, DOI 10.15252/embj.201696151
NR 233
TC 84
Z9 90
U1 0
U2 32
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD MAR
PY 2019
VL 111
BP 503
EP 516
DI 10.1016/j.biopha.2018.12.108
PG 14
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA HL5AK
UT WOS:000458737800056
PM 30597304
OA gold
DA 2025-06-11
ER

PT J
AU Sud, N
   Rutledge, AC
   Pan, KC
   Su, QZ
AF Sud, Neetu
   Rutledge, Angela C.
   Pan, Kaichao
   Su, Qiaozhu
TI Activation of the dsRNA-Activated Protein Kinase PKR in Mitochondrial
   Dysfunction and Inflammatory Stress in Metabolic Syndrome
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE dsRNA-Activated Protein Kinase PKR; Mitochondrial dysfunction; ER
   stress; Metaflammation; Metabolic diseases
ID DOUBLE-STRANDED-RNA; ENDOPLASMIC-RETICULUM STRESS; NF-KAPPA-B; LIPOTOXIC
   CELL-DEATH; I IGF-I; TYROSINE PHOSPHORYLATION; INSULIN-RESISTANCE;
   SUBSTRATE RECOGNITION; TRANSLATIONAL CONTROL; DIMERIZATION DOMAINS
AB Background: The double stranded RNA (dsRNA)-activated protein kinase PKR is a well-established protein kinase that is activated by dsRNA during viral infection, and it inhibits global protein synthesis by phosphorylating the alpha subunit of eukaryotic initiation factor 2 alpha (eIF2 alpha). Recent studies have greatly broadened the recognized physiological activities of PKR by demonstrating its fundamental role in inflammatory signaling, particularly in chronic, low-grade inflammation induced by metabolic disorders, known as metaflammation. Metaflammation is initiated by the activation of the NOD-like receptor (NLR), leucine-rich repeat, pyrin domaincontaining 3 (NLRP3) gene by mitochondrial reactive oxygen species (ROS). A protein complex defined as the metaflammasome is assembled in the course of metaflammation. This complex integrates nutritional signaling with cellular stress, inflammatory components, and insulin action and is essential in maintaining metabolic homeostasis. PKR is a key constituent of the metaflammasome and interacts directly with several inflammatory kinases, such as inhibitor kappa B (I kappa B) kinase (IKK) and c-Jun N-terminal kinase (JNK), insulin receptor substrate 1 (IRS1), and component of the translational machinery such as eIF2 alpha. Conclusion: This review highlights recent findings in PKR-mediated metaflammation and its association with the onset of metabolic syndrome in both human and animal models, with a focus on the molecular and biochemical pathways that underlie the progression of obesity, insulin resistance, and type-2 diabetes.
C1 [Sud, Neetu; Pan, Kaichao; Su, Qiaozhu] Univ Nebraska, Dept Nutr & Hlth Sci, Lincoln, NE 68583 USA.
   [Rutledge, Angela C.] London Hlth Sci Ctr, Dept Pathol & Lab Med, London, ON, Canada.
C3 University of Nebraska System; University of Nebraska Lincoln; London
   Health Sciences Centre
RP Su, QZ (corresponding author), Univ Nebraska, 316F Leverton Hall, Lincoln, NE 68583 USA.
EM qsu2@unl.edu
OI Su, Qiaozhu/0000-0001-8434-1408; Rutledge, Angela/0000-0001-9106-316X
FU NIH [P20 GM104320-01A1]
FX This work was supported by a P20 GM104320-01A1 grant award from NIH to
   Q. Su.
CR Akashi S, 2003, J EXP MED, V198, P1035, DOI 10.1084/jem.20031076
   Amici C, 2015, CELL MICROBIOL, V17, P1391, DOI 10.1111/cmi.12446
   Anderwald CH, 2012, DIABETES CARE, V35, P2580, DOI 10.2337/dc12-0197
   Ben-Asouli Y, 2002, CELL, V108, P221, DOI 10.1016/S0092-8674(02)00616-5
   Bennett RL, 2004, J BIOL CHEM, V279, P42687, DOI 10.1074/jbc.M403321200
   Bleiblo F, 2013, INT J CLIN EXP MED, V6, P16
   Bleiblo F, 2012, J THORAC DIS, V4, P114, DOI 10.3978/j.issn.2072-1439.2012.01.07
   Bonnet MC, 2000, MOL CELL BIOL, V20, P4532, DOI 10.1128/MCB.20.13.4532-4542.2000
   Borradaile NM, 2006, J LIPID RES, V47, P2726, DOI 10.1194/jlr.M600299-JLR200
   Borradaile NM, 2006, MOL BIOL CELL, V17, P770, DOI 10.1091/mbc.E05-08-0742
   Brunelli C, 2012, BIOCHEM J, V443, P379, DOI 10.1042/BJ20111236
   Cabanski M, 2008, AM J RESP CELL MOL, V38, P26, DOI 10.1165/rcmb.2007-0010OC
   Carvalho BM, 2013, OBESITY, V21, P2452, DOI 10.1002/oby.20410
   Carvalho MA, 2012, ENDOCRINOLOGY, V153, P5261, DOI 10.1210/en.2012-1400
   Chakrabarti A, 2008, J BIOL CHEM, V283, P25132, DOI 10.1074/jbc.M804770200
   Cheung BKW, 2005, J IMMUNOL, V175, P7218, DOI 10.4049/jimmunol.175.11.7218
   Cho H, 2013, BMC SYST BIOL, V7, DOI 10.1186/1752-0509-7-9
   Clerzius G, 2013, RETROVIROLOGY, V10, DOI 10.1186/1742-4690-10-96
   Cole JL, 2007, TRENDS BIOCHEM SCI, V32, P57, DOI 10.1016/j.tibs.2006.12.003
   Daher A, 2001, J BIOL CHEM, V276, P33899, DOI 10.1074/jbc.M103584200
   Dar AC, 2005, CELL, V122, P887, DOI 10.1016/j.cell.2005.06.044
   de Lucas S, 2005, J INFECT DIS, V191, P93, DOI 10.1086/426509
   Demaurex N, 2003, SCIENCE, V300, P65, DOI 10.1126/science.1083628
   Dey M, 2005, CELL, V122, P901, DOI 10.1016/j.cell.2005.06.041
   Egnatchik RA, 2013, FASEB J, V27
   Eley HL, 2008, MOL CELL BIOCHEM, V313, P63, DOI 10.1007/s11010-008-9742-4
   Eley HL, 2007, BRIT J CANCER, V96, P1216, DOI 10.1038/sj.bjc.6603704
   Gao ZG, 2004, MOL ENDOCRINOL, V18, P2024, DOI 10.1210/me.2003-0383
   García MA, 2007, BIOCHIMIE, V89, P799, DOI 10.1016/j.biochi.2007.03.001
   García MA, 2006, MICROBIOL MOL BIOL R, V70, P1032, DOI 10.1128/MMBR.00027-06
   Gil J, 2000, ONCOGENE, V19, P1369, DOI 10.1038/sj.onc.1203448
   Goh KC, 2000, EMBO J, V19, P4292, DOI 10.1093/emboj/19.16.4292
   Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
   Harding HP, 2002, ANNU REV CELL DEV BI, V18, P575, DOI 10.1146/annurev.cellbio.18.011402.160624
   He Y, 2013, EUR J IMMUNOL, V43, P1147, DOI 10.1002/eji.201243187
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   Hummasti S, 2010, CIRC RES, V107, P579, DOI 10.1161/CIRCRESAHA.110.225698
   Huse M, 2002, CELL, V109, P275, DOI 10.1016/S0092-8674(02)00741-9
   Israël A, 2010, CSH PERSPECT BIOL, V2, DOI 10.1101/cshperspect.a000158
   Jiang HY, 2004, MOL CELL BIOL, V24, P1365, DOI 10.1128/MCB.24.3.1365-1377.2004
   Kaempfer R, 2003, EMBO REP, V4, P1043, DOI 10.1038/sj.embor.7400005
   Kahn SE, 2006, NATURE, V444, P840, DOI 10.1038/nature05482
   Kapil P, 2014, J NEUROIMMUNOL, V270, P1, DOI 10.1016/j.jneuroim.2014.02.012
   Lee ES, 2007, FEBS LETT, V581, P4325, DOI 10.1016/j.febslet.2007.08.001
   Lemaire PA, 2005, J MOL BIOL, V345, P81, DOI 10.1016/j.jmb.2004.10.031
   Lemaire PA, 2006, BIOCHEMISTRY-US, V45, P9074, DOI 10.1021/bi060567d
   Lipniacki T, 2004, J THEOR BIOL, V228, P195, DOI 10.1016/j.jtbi.2004.01.001
   Listenberger LL, 2001, J BIOL CHEM, V276, P14890, DOI 10.1074/jbc.M010286200
   Lowell BB, 2005, SCIENCE, V307, P384, DOI 10.1126/science.1104343
   Lu B, 2012, NATURE, V488, P670, DOI 10.1038/nature11290
   Luo K, 2015, GASTROENT RES PRACT, V2015, DOI 10.1155/2015/328791
   Mittelstadt M, 2008, NUCLEIC ACIDS RES, V36, P998, DOI 10.1093/nar/gkm1129
   Moeschel K, 2004, J BIOL CHEM, V279, P25157, DOI 10.1074/jbc.M402477200
   Nakamura T, 2014, DIABETES, V63, P526, DOI 10.2337/db13-1019
   Nakamura T, 2010, CELL, V140, P338, DOI 10.1016/j.cell.2010.01.001
   Nallagatla SR, 2008, RNA, V14, P1201, DOI 10.1261/rna.1007408
   Nallagatla SR, 2007, SCIENCE, V318, P1455, DOI 10.1126/science.1147347
   Nanduri S, 2000, EMBO J, V19, P5567, DOI 10.1093/emboj/19.20.5567
   Nehra V, 2001, DIGEST DIS SCI, V46, P2347, DOI 10.1023/A:1012338828418
   Nie YZ, 2007, J VIROL, V81, P917, DOI 10.1128/JVI.01527-06
   Okumura F, 2013, J BIOL CHEM, V288, P2839, DOI 10.1074/jbc.M112.401851
   Oliveira JMA, 2010, J NEUROCHEM, V114, P1, DOI 10.1111/j.1471-4159.2010.06741.x
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Patti ME, 2010, ENDOCR REV, V31, P364, DOI 10.1210/er.2009-0027
   Pederson TM, 2001, DIABETES, V50, P24, DOI 10.2337/diabetes.50.1.24
   Peters GA, 2001, MOL CELL BIOL, V21, P1908, DOI 10.1128/MCB.21.6.1908-1920.2001
   Ramos APP, 2006, OBES SURG, V16, P1359, DOI 10.1381/096089206778663706
   Rath E, 2012, GUT, V61, P1269, DOI 10.1136/gutjnl-2011-300767
   Raven JF, 2008, CELL CYCLE, V7, P1146, DOI 10.4161/cc.7.9.5811
   Renz H, 2011, NAT IMMUNOL, V12, P273, DOI 10.1038/ni0411-273
   Ron D, 2007, NAT REV MOL CELL BIO, V8, P519, DOI 10.1038/nrm2199
   Roobol A, 2015, BIOCHEM J, V465, P213, DOI 10.1042/BJ20140852
   Rothenburg S, 2011, BMC MICROBIOL, V11, DOI 10.1186/1471-2180-11-56
   Russell ST, 2007, CELL SIGNAL, V19, P1583, DOI 10.1016/j.cellsig.2007.02.005
   Shimazawa M, 2007, INVEST OPHTH VIS SCI, V48, P3729, DOI 10.1167/iovs.06-1122
   Shkoda A, 2007, GASTROENTEROLOGY, V132, P190, DOI 10.1053/j.gastro.2006.10.030
   Simmen T, 2010, BBA-BIOMEMBRANES, V1798, P1465, DOI 10.1016/j.bbamem.2010.04.009
   Singh M, 2009, J MOL BIOL, V385, P457, DOI 10.1016/j.jmb.2008.10.068
   Siyan S, 2012, INFLAMM BOWEL DIS, V18, P1735, DOI 10.1002/ibd.22878
   Spanggord RJ, 2002, BIOCHEMISTRY-US, V41, P4511, DOI 10.1021/bi0120594
   Sparagna GC, 2000, AM J PHYSIOL-HEART C, V279, pH2124, DOI 10.1152/ajpheart.2000.279.5.H2124
   Su QZ, 2006, P NATL ACAD SCI USA, V103, P63, DOI 10.1073/pnas.0508207103
   Tergaonkar V, 2003, MOL CELL BIOL, V23, P8070, DOI 10.1128/MCB.23.22.8070-8083.2003
   Ung TL, 2001, EMBO J, V20, P3728, DOI 10.1093/emboj/20.14.3728
   Urano F, 2000, SCIENCE, V287, P664, DOI 10.1126/science.287.5453.664
   van Huizen R, 2003, J BIOL CHEM, V278, P15558, DOI 10.1074/jbc.M212074200
   Vandanmagsar B, 2011, NAT MED, V17, P179, DOI 10.1038/nm.2279
   Wang CH, 2013, FEBS J, V280, P1039, DOI 10.1111/febs.12096
   Wei Y, 2007, MOL CELL BIOCHEM, V303, P105, DOI 10.1007/s11010-007-9461-2
   Wek RC, 2006, BIOCHEM SOC T, V34, P7, DOI 10.1042/BST0340007
   Wu M, 2009, PLOS ONE, V4
   Yang XR, 2010, MOL BIOL CELL, V21, P3449, DOI 10.1091/mbc.E10-06-0481
   Yoon CH, 2009, P NATL ACAD SCI USA, V106, P7852, DOI 10.1073/pnas.0812148106
   Youssef OA, 2015, P NATL ACAD SCI USA, V112, P5023, DOI 10.1073/pnas.1424044112
   Zamanian-Daryoush M, 2000, MOL CELL BIOL, V20, P1278, DOI 10.1128/MCB.20.4.1278-1290.2000
   Zhang F, 2001, J BIOL CHEM, V276, P24946, DOI 10.1074/jbc.M102108200
   Zhang JD, 2001, P NATL ACAD SCI USA, V98, P3756, DOI 10.1073/pnas.071054598
   Zhao Q, 2002, EMBO J, V21, P4411, DOI 10.1093/emboj/cdf445
   Zheng XF, 2004, RNA, V10, P1934, DOI 10.1261/rna.7150804
   Zhou RB, 2011, NATURE, V469, P221, DOI 10.1038/nature09663
NR 102
TC 26
Z9 29
U1 1
U2 12
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2016
VL 22
IS 18
BP 2697
EP 2703
DI 10.2174/1381612822666160202141845
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DM6HP
UT WOS:000376452500010
PM 26831644
DA 2025-06-11
ER

PT J
AU Kishina, M
   Koda, M
   Kato, J
   Tokunaga, S
   Matono, T
   Sugihara, T
   Ueki, M
   Murawaki, Y
AF Kishina, Manabu
   Koda, Masahiko
   Kato, Jun
   Tokunaga, Shiho
   Matono, Tomomitsu
   Sugihara, Takaaki
   Ueki, Masaru
   Murawaki, Yoshikazu
TI Therapeutic effects of the direct renin inhibitor, aliskiren, on
   non-alcoholic steatohepatitis in fatty liver Shionogi
   ob/ob male mice
SO HEPATOLOGY RESEARCH
LA English
DT Article
DE direct renin inhibitors; liver fibrosis; liver steatosis; non-alcoholic
   steatohepatitis; oxidative stress
ID TYPE-1 RECEPTOR BLOCKER; BILE-DUCT LIGATION; ANGIOTENSIN SYSTEM;
   HEPATIC-FIBROSIS; INSULIN-RESISTANCE; OXIDATIVE STRESS; INFLAMMATION;
   MOUSE; STEATOSIS; OBESITY
AB Aim: Non-alcoholic steatohepatitis (NASH) is a manifestation of metabolic syndrome in the liver that is characterized by hepatic fat accumulation, inflammation and varying degrees of fibrosis. The renin-angiotensin system (RAS) appears to play important roles in NASH. Direct renin inhibitors (DRI) reduce plasma renin activity (PRA) through interaction with the active site of the enzyme and reduce the formation of angiotensin-II (AT-II). Therefore, the DRI aliskiren may further suppress the RAS. This study examined the effects of aliskiren on NASH in fatty liver Shionogi (FLS)-ob/ob male mice that are the closest animal model of metabolic syndrome-related NASH in humans.
   Methods: Aliskiren (100 mg/kg per day, aliskiren group) or a placebo (control group) was p.o. administrated to eight FLS-ob/ob mice each for 16 weeks and factors including steatosis, fibrosis, inflammation and oxidative stress were compared between the two groups.
   Results: Amounts of hepatic fibrosis were significantly lower in the aliskiren group than in the control group. Areas of alpha-smooth muscle actin positivity, the numbers of F4/80 positive, 8-hydroxy-2-deoxyguanosine positive cells and immunohistochemical staining of 4-hydroxynonenal were also significantly decreased in the aliskiren group. Levels of RNA expression for transforming growth factor-beta 1, connective tissue growth factor and monocyte chemoattractant protein-1 were significantly lower in the aliskiren group.
   Conclusion: Aliskiren attenuated the progression of hepatic fibrosis by inhibiting the activation of hepatic stellate and Kupffer cells and by reducing oxidative stress.
C1 [Kishina, Manabu; Koda, Masahiko; Kato, Jun; Tokunaga, Shiho; Matono, Tomomitsu; Sugihara, Takaaki; Ueki, Masaru; Murawaki, Yoshikazu] Tottori Univ, Fac Med, Dept Multidisciplinary Internal Med, Div Med & Clin Sci, Yonago, Tottori 683, Japan.
C3 Tottori University
RP Koda, M (corresponding author), 36-1 Nishi Machi, Yonago, Tottori 6838504, Japan.
EM masakoda@med.tottori-u.ac.jp
RI Kato, Junya/O-6144-2015
CR Aihara Y, 2013, HEPATOL RES
   de Kloet AD, 2010, PHYSIOL BEHAV, V100, P525, DOI 10.1016/j.physbeh.2010.03.018
   El-Demerdash E, 2008, CLIN EXP PHARMACOL P, V35, P159, DOI 10.1111/j.1440-1681.2007.04797.x
   Hashimoto E, 2011, J GASTROENTEROL, V46, P63, DOI 10.1007/s00535-010-0311-8
   Hirose A, 2007, HEPATOLOGY, V45, P1375, DOI 10.1002/hep.21638
   Kalupahana NS, 2012, OBES REV, V13, P136, DOI 10.1111/j.1467-789X.2011.00942.x
   Kanda H, 2006, J CLIN INVEST, V116, P1494, DOI 10.1172/JCI26498
   Kato J, 2012, INT J MOL MED, V30, P107, DOI 10.3892/ijmm.2012.958
   Kurita S, 2008, EUR J PHARMACOL, V588, P316, DOI 10.1016/j.ejphar.2008.04.028
   Lee KC, 2012, EUR J CLIN INVEST, V42, P1261, DOI 10.1111/j.1365-2362.2012.02725.x
   Luo XQ, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-34
   Marique C, 2009, MED CLIN N AM, V93, P569
   Obstfeld AE, 2010, DIABETES, V59, P916, DOI 10.2337/db09-1403
   Paizis G, 2002, GASTROENTEROLOGY, V123, P1667, DOI 10.1053/gast.2002.36561
   Pascale A, 2010, J GASTROINTEST LIVER, V19, P415
   Rector RS, 2008, WORLD J GASTROENTERO, V14, P185, DOI 10.3748/wjg.14.185
   Rooyen DMV, 2011, GASTROENTEROLOGY, V141, P1393
   Singh VP, 2008, DIABETES, V57, P3297, DOI 10.2337/db08-0805
   Soga M, 1999, LAB ANIM SCI, V49, P269
   Soga M, 2010, EXP ANIM TOKYO, V59, P407, DOI 10.1538/expanim.59.407
   Sugihara T, 2013, HEPATOL RES, V43, P547, DOI 10.1111/j.1872-034X.2012.01101.x
   Ueki M, 2006, J GASTROENTEROL, V41, P996, DOI 10.1007/s00535-006-1891-1
   Ueki M, 2009, HEPATO-GASTROENTEROL, V56, P1100
   Ueki M, 2009, MOL MED REP, V2, P857, DOI 10.3892/mmr_00000184
   Wouters K, 2008, HEPATOLOGY, V48, P474, DOI 10.1002/hep.22363
   Wu WP, 2010, AM J PHYSIOL-RENAL, V299, pF929, DOI 10.1152/ajprenal.00192.2010
NR 26
TC 14
Z9 16
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1386-6346
EI 1872-034X
J9 HEPATOL RES
JI Hepatol. Res.
PD AUG
PY 2014
VL 44
IS 8
BP 888
EP 896
DI 10.1111/hepr.12186
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AM6DD
UT WOS:000339951200009
PM 23777387
DA 2025-06-11
ER

PT J
AU Martín-Cordero, L
   García, JJ
   Hinchado, MD
   Bote, E
   Ortega, E
AF Martin-Cordero, L.
   Garcia, J. J.
   Hinchado, M. D.
   Bote, E.
   Ortega, E.
TI Influence of exercise on NA- and Hsp72-induced release of IFNγ by the
   peritoneal suspension of macrophages and lymphocytes from genetically
   obese Zucker rats
SO JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Exercise; Hsp72; IFN gamma; Macrophages; Metabolic syndrome; NA
ID METABOLIC SYNDROME; INDUCED STIMULATION; MURINE MACROPHAGES;
   PHYSICAL-ACTIVITY; INTERFERON-GAMMA; IMMUNE-RESPONSE; DANGER SIGNAL;
   STRESS; NORADRENALINE; INFLAMMATION
AB Regular physical exercise is recognized as a nonpharmacological therapeutic strategy in the treatment of metabolic syndrome, and has been proposed for improving obesity, diabetic status, insulin resistance, and immune response. The aim of the present study was to evaluate the effect of a regular exercise program (treadmill running, 5 days/week for 14 weeks at 35 cm/s for 35 min in the last month) on the release of the pro-inflammatory cytokine interferon gamma (IFN gamma) by peritoneal cells (macrophages and lymphocytes) from obese Zucker rats (fa/fa) in response to noradrenaline (NA) and heat shock proteins of 72 kDa (Hsp72), and the possible adaptation due to training for a bout acute exercise (a single session of 25-35 min at 35 cm/s). In healthy (lean Fa/fa) and obese animals, peritoneal cells released greater concentrations of IFN gamma in response to Hsp72 and lower concentrations in response to NA. The regular exercise training protocol, evaluated in the obese animals, produced a clear change in the regulation of the release of IFN gamma. Peritoneal immune cells from trained animals released more IFN gamma in response to NA, but there was a reduction in the release of IFN gamma in response to Hsp72. In the obese animals, regular exercise caused a change in the inhibitory effect of NA (which now becomes stimulatory) and the stimulatory effect of Hsp72e (which now becomes inhibitory) in relation to the release of IFN gamma. This reflects that Hsp72, induced by the prior release of NA following exercise-induced stress, plays a role in the homeostatic balance of release of IFN gamma by peritoneal immune cells in obese animals during exercise.
C1 [Martin-Cordero, L.; Garcia, J. J.; Hinchado, M. D.; Bote, E.; Ortega, E.] Univ Extremadura, Fac Sci, Dept Physiol, Immunophysiol Res Grp, E-06071 Badajoz, Spain.
   [Ortega, E.] Univ Extremadura, Fac Sci, Dept Physiol, E-06071 Badajoz, Spain.
C3 Universidad de Extremadura; Universidad de Extremadura
RP Ortega, E (corresponding author), Univ Extremadura, Fac Sci, Dept Physiol, E-06071 Badajoz, Spain.
EM orincon@unex.es
RI Ortega, Eduardo/H-9891-2016; Garcia, Juan/C-7383-2013; Martin-Cordero,
   Leticia/H-9711-2015
OI Ortega, Eduardo/0000-0002-7007-7615; Bote, Maria
   Elena/0000-0002-3112-9259; HINCHADO SANCHEZ-MORO, MARIA
   DOLORES/0000-0002-9709-4714; Garcia, Juan/0000-0002-8222-4213;
   Martin-Cordero, Leticia/0000-0002-3651-2265
FU Ministry of Science and Innovation [DEP2006-56187-C04-03]; Junta de
   Extremadura [GRU10020]; FEDER; RETICEF; Fundacion Valhondo de
   Extremadura, Spain
FX This work was partially supported by grants from the Ministry of Science
   and Innovation (DEP2006-56187-C04-03), Junta de Extremadura (GRU10020),
   FEDER, RETICEF, and Fundacion Valhondo de Extremadura, Spain.
CR Asea A, 2000, NAT MED, V6, P435, DOI 10.1038/74697
   Bassuk SS, 2005, J APPL PHYSIOL, V99, P1193, DOI 10.1152/japplphysiol.00160.2005
   Campisi J, 2003, CELL STRESS CHAPERON, V8, P272, DOI 10.1379/1466-1268(2003)008<0272:SEHIAF>2.0.CO;2
   Das UN, 2002, EXP BIOL MED, V227, P989, DOI 10.1177/153537020222701106
   de Lemos ET, 2009, NUTRITION, V25, P330, DOI 10.1016/j.nut.2008.08.014
   de Lemos ET, 2007, MED SCI MONITOR, V13, pBR172
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Elenkov IJ, 2002, ANN NY ACAD SCI, V966, P290, DOI 10.1111/j.1749-6632.2002.tb04229.x
   Fleshner M, 2003, EXERC IMMUNOL REV, V9, P6
   FORNER MA, 1995, J PHYSIOL-LONDON, V488, P789, DOI 10.1113/jphysiol.1995.sp021010
   García JJ, 2003, MOL CELL BIOCHEM, V254, P299, DOI 10.1023/A:1027345820519
   Giraldo E, 2010, BRAIN BEHAV IMMUN, V24, P672, DOI 10.1016/j.bbi.2010.02.003
   Martin-Cordero L, 2009, EUR J APPL PHYSIOL, V107, P535, DOI 10.1007/s00421-009-1140-4
   Martín-Cordero L, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-42
   Martín-Cordero L, 2011, NEUROIMMUNOMODULAT, V18, P123, DOI 10.1159/000322053
   Matzinger P, 1998, SEMIN IMMUNOL, V10, P399, DOI 10.1006/smim.1998.0143
   MATZINGER P, 1994, ANNU REV IMMUNOL, V12, P991, DOI 10.1146/annurev.iy.12.040194.005015
   Moseley PL, 1998, ANN NY ACAD SCI, V856, P206, DOI 10.1111/j.1749-6632.1998.tb08327.x
   Munder M, 1998, J EXP MED, V187, P2103, DOI 10.1084/jem.187.12.2103
   Ortega E, 2000, EXP PHYSIOL, V85, P519, DOI 10.1017/S0958067000020509
   Ortega E, 2006, EUR J APPL PHYSIOL, V98, P250, DOI 10.1007/s00421-006-0269-7
   Ortega E, 2005, EUR J APPL PHYSIOL, V93, P714, DOI 10.1007/s00421-004-1245-8
   Ortega E, 2003, EXERC IMMUNOL REV, V9, P70
   Ortega E, 2009, EXERC IMMUNOL REV, V15, P42
   Ortega E, 2000, MECH AGEING DEV, V118, P103, DOI 10.1016/S0047-6374(00)00160-3
   Ortega E, 1994, INT J SPORTS MED, V15, P5172
   Ortega E, 2007, NEUROIMMUNOMODULAT, V14, P206, DOI 10.1159/000110648
   Ortega E, 2010, HEAT SHOCK PROTEINS, V5, P327, DOI 10.1007/978-90-481-3381-9_19
   Pitsavos C, 2005, EUR J CARDIOV PREV R, V12, P151, DOI 10.1097/00149831-200504000-00010
   Plotkin BJ, 1996, J MED MICROBIOL, V44, P277, DOI 10.1099/00222615-44-4-277
   Puddu P, 1997, J IMMUNOL, V159, P3490
   Regueiro J., 2010, INMUNOLOGIA BIOL PAT
   Thäle C, 2005, IMMUNOBIOLOGY, V210, P673, DOI 10.1016/j.imbio.2005.07.003
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Wen YS, 2006, ENDOCRINOLOGY, V147, P2518, DOI 10.1210/en.2005-0519
   Zimmet P, 2005, REV ESP CARDIOL, V58, P1371, DOI 10.1016/S1885-5857(06)60742-1
NR 36
TC 8
Z9 9
U1 0
U2 8
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1138-7548
EI 1877-8755
J9 J PHYSIOL BIOCHEM
JI J. Physiol. Biochem.
PD MAR
PY 2013
VL 69
IS 1
BP 125
EP 131
DI 10.1007/s13105-012-0196-5
PG 7
WC Biochemistry & Molecular Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Physiology
GA 088NP
UT WOS:000314842100013
PM 22798210
DA 2025-06-11
ER

PT J
AU Mohebbi, I
   Saadat, S
   Aghassi, M
   Shekari, M
   Matinkhah, M
   Sehat, S
AF Mohebbi, Iraj
   Saadat, Soheil
   Aghassi, Mohammadreza
   Shekari, Mahsa
   Matinkhah, Maghsuod
   Sehat, Shadi
TI Prevalence of Metabolic Syndrome in Iranian Professional Drivers:
   Results from a Population Based Study of 12,138 Men
SO PLOS ONE
LA English
DT Article
ID CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; RISK-FACTORS; WAIST
   CIRCUMFERENCE; CIGARETTE-SMOKING; UNITED-STATES; MORTALITY; HEALTH;
   IMPACT; EAST
AB Background: It is evident that professional driving is associated with substantial changes in lifestyle habits. Professional drivers are prone to metabolic syndrome (MetS) and its complications because their working environment is characterized by numerous stress factors such as lack of physical activity due to working in a fixed position, disruption in diet, and irregular sleep habits. The aim of the present study was to estimate the prevalence of MetS among long distance drivers residing in West Azerbaijan province in Iran.
   Materials: To assess the prevalence of metabolic syndrome among professional long distance drivers, 12138 participants were enrolled in this cross sectional study. The MetS was defined using International Diabetes Federation criteria.
   Results: Among 12138 participants, 3697 subjects found to be MetS. The crude and age-adjusted rates of MetS were 30.5% and 32.4% respectively. Based on Body mass index (BMI), 5027 subjects (41.4%) were overweight (BMI >= 25.01-30 kg/m2), and 2592 (21.3%) were obese (BMI >= 30.01 kg/m2). The presence of central obesity was more common than other components. The associations of MetS with BMI, pack-year smoking, age, weekly driving duration and driving experiences were significant in the logistic regression. By increasing BMI, pack-year smoking, age, weekly driving duration and driving experiences, odds ratio of MetS was increased.
   Conclusion: The study suggests that MetS has become a noteworthy health problem among Iranian long distance drivers. This might be due to the following facts: sitting in a fixed position for long hours while working, cigarette smoking, job stress, unhealthy diet and lack of physical activity. Educational programs should be established for promoting healthy lifestyle and also for early detection and appropriate interventions
C1 [Mohebbi, Iraj; Shekari, Mahsa; Matinkhah, Maghsuod; Sehat, Shadi] Urmia Univ Med Sci, Occupat Med Ctr, Orumiyeh, Iran.
   [Saadat, Soheil] Med Sci Univ Tehran, Sina Hosp, Sina Trauma Res Ctr, Tehran, Iran.
   [Aghassi, Mohammadreza] Urmia Univ Med Sci, Dept Endocrinol, Orumiyeh, Iran.
C3 Urmia University of Medical Sciences; Tehran University of Medical
   Sciences; Urmia University of Medical Sciences
RP Mohebbi, I (corresponding author), Urmia Univ Med Sci, Occupat Med Ctr, Orumiyeh, Iran.
EM irajmohebbi@umsu.ac.ir
RI Mohebbi, Iraj/G-1494-2017; Saadat, Soheil/J-1595-2014
OI Mohebbi, Iraj/0000-0001-9158-5742
CR Ahmad OB, 2001, WHO DISCUSSION PAPER
   [Anonymous], INT DIAB FED IDF CON
   Azizi F, 2003, DIABETES RES CLIN PR, V61, P29, DOI 10.1016/S0168-8227(03)00066-4
   Bonora E, 2003, DIABETES CARE, V26, P1251, DOI 10.2337/diacare.26.4.1251
   Borch-Johnsen K, 2007, DAN MED BULL, V54, P157
   Branth S, 2007, NUTR METAB CARDIOVAS, V17, P427, DOI 10.1016/j.numecd.2006.03.001
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Chen CC, 2008, METABOLISM, V57, P544, DOI 10.1016/j.metabol.2007.11.018
   Dekker JM, 2005, CIRCULATION, V112, P666, DOI 10.1161/CIRCULATIONAHA.104.516948
   Delavari A, 2009, DIABETES CARE, V32, P1092, DOI 10.2337/dc08-1800
   Eapen D, 2009, VASC HEALTH RISK MAN, V5, P731
   Eberly LE, 2006, DIABETES CARE, V29, P123, DOI 10.2337/diacare.29.01.06.dc05-1320
   Emdad R, 1998, PSYCHOTHER PSYCHOSOM, V67, P226, DOI 10.1159/000012285
   Enas Enas A, 2007, J Cardiometab Syndr, V2, P267, DOI 10.1111/j.1559-4564.2007.07392.x
   Ford ES, 2004, ATHEROSCLEROSIS, V173, P309, DOI 10.1016/j.atherosclerosis.2003.12.022
   FRENCH SA, 1994, INT J OBESITY, V18, P145
   HARTVIG P, 1983, INT ARCH OCC ENV HEA, V52, P353, DOI 10.1007/BF02226900
   Kompier M.A.J., 1996, Bus drivers: Occupational stress and stress prevention
   Kurosaka K, 2000, IND HEALTH, V38, P15, DOI 10.2486/indhealth.38.15
   Lee WY, 2005, DIABETES RES CLIN PR, V67, P70, DOI 10.1016/j.diabres.2004.05.006
   Lorenzo C, 2003, DIABETES CARE, V26, P3153, DOI 10.2337/diacare.26.11.3153
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Misra A, 2009, BRIT J NUTR, V101, P465, DOI 10.1017/S0007114508073649
   Miyatake N, 2006, INTERNAL MED, V45, P1039, DOI 10.2169/internalmedicine.45.1850
   Mokdad AH, 1999, JAMA-J AM MED ASSOC, V282, P1519, DOI 10.1001/jama.282.16.1519
   Mokdad AH, 2001, JAMA-J AM MED ASSOC, V286, P1195, DOI 10.1001/jama.286.10.1195
   MORRIS JN, 1953, LANCET, V265, P1053
   MORRIS JN, 1953, LANCET, V265, P1111
   Nakamura K, 1998, OCCUP MED-OXFORD, V48, P169, DOI 10.1093/occmed/48.3.169
   Nestel P, 2007, ASIA PAC J CLIN NUTR, V16, P362
   Saberi HR, 2011, DIABETOL METAB SYNDR, V3, DOI 10.1186/1758-5996-3-8
   Sharifi F, 2009, EXP DIABETES RES, DOI 10.1155/2009/136501
   Wang PD, 2001, PUBLIC HEALTH, V115, P261, DOI 10.1016/S0033-3506(01)00456-5
   Zabetian A, 2007, DIABETES RES CLIN PR, V77, P251, DOI 10.1016/j.diabres.2006.12.001
NR 34
TC 35
Z9 40
U1 1
U2 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 22
PY 2012
VL 7
IS 2
AR e31790
DI 10.1371/journal.pone.0031790
PG 5
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 926ZZ
UT WOS:000302875500041
PM 22384075
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Cho, Y
   Lim, TH
   Kang, H
   Lee, Y
   Lee, H
   Kim, H
AF Cho, Yongil
   Lim, Tae Ho
   Kang, Hyunggoo
   Lee, Yoonje
   Lee, Heekyung
   Kim, Hongjung
TI Socioeconomic status and depression as combined risk factors for acute
   myocardial infarction and stroke: A population-based study of 2.7
   million Korean adults
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Socioeconomic status; Depression; Acute myocardial infarction; Stroke
ID CORONARY-HEART-DISEASE; CAUSE-SPECIFIC MORTALITY; INTIMA-MEDIA
   THICKNESS; CARDIOVASCULAR-DISEASE; PSYCHOLOGICAL DISTRESS; COMBINED
   ASSOCIATION; METABOLIC SYNDROME; PUBLIC SERVANTS; ALL-CAUSE; SYMPTOMS
AB Objectives: To evaluate the separate and combined associations of socioeconomic status (SES) and depression with the incidences of acute myocardial infarction (AMI) and stroke.
   Methods: We conducted a population-based cohort study using nationwide health insurance claims data collected from 2002 to 2016 in South Korea. A total of 2,705,090 subjects aged 20 years or older for whom had health screening data were collected between 2004 and 2005 were analyzed. The hazard ratios (HRs) for the incidences of AMI and stroke were calculated using Cox proportional regression analyses.
   Results: After adjusting for cardiovascular risk factors, a low SES was associated with increased risks of AMI (HR, 1.16; 95% confidence interval (CI), 1.14-1.19) and stroke (HR, 1.13; 95% CI, 1.11-1.14) incidence. Depression was also associated with an increased incidence of AMI (HR, 1.26; 95% CI, 1.21-1.31) and stroke (HR, 1.24; 95% CI, 1.21-1.27). Patients with depression who had a low SES exhibited significantly increased risks of AMI (HR, 1.47; 95% CI, 1.36-1.60) and stroke (HR, 1.37; 95% CI, 1.30-1.44) compared to patients with a high SES who were not diagnosed with depression. Depression showed a positive effect modification of low and medium SES compared to high SES on the association with AMI but not with stroke.
   Conclusions: Subjects with both a low SES and depression displayed the highest risk. Both SES and depression should be considered in cardiovascular risk assessments, particularly in individuals with depression who have a low SES.
C1 [Cho, Yongil; Lim, Tae Ho; Kang, Hyunggoo; Lee, Yoonje; Lee, Heekyung; Kim, Hongjung] Hanyang Univ, Coll Med, Dept Emergency Med, 222 Wangsimni Ro St, Seoul 04763, South Korea.
C3 Hanyang University
RP Lim, TH (corresponding author), Hanyang Univ, Coll Med, Dept Emergency Med, 222 Wangsimni Ro St, Seoul 04763, South Korea.
EM erthim@gmail.com
RI Cho, Yongil/LZF-3835-2025; Cho, Yongil/R-7828-2016; LEE,
   YOONJE/R-7311-2016
OI Lim, Tae Ho/0000-0003-1045-413X; Cho, Yongil/0000-0001-5027-6345; LEE,
   YOONJE/0000-0001-6478-7568; Kim, Hongjung/0000-0003-4003-8612
CR Addo J, 2012, STROKE, V43, P1186, DOI 10.1161/STROKEAHA.111.639732
   Agyemang C, 2014, HEART, V100, P239, DOI 10.1136/heartjnl-2013-304721
   Almas A, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0140742
   Aschbacher K, 2008, BRAIN BEHAV IMMUN, V22, P493, DOI 10.1016/j.bbi.2007.10.002
   Bray BD, 2018, LANCET PUBLIC HEALTH, V3, pE185, DOI 10.1016/S2468-2667(18)30030-6
   Butterworth P, 2012, AUST NZ J PSYCHIAT, V46, P364, DOI 10.1177/0004867411433215
   Cesari M, 2003, CIRCULATION, V108, P2317, DOI 10.1161/01.CIR.0000097109.90783.FC
   Cho HJ, 2007, INT J EPIDEMIOL, V36, P50, DOI 10.1093/ije/dyl239
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   Damen JAAG, 2016, BMJ-BRIT MED J, V353, DOI 10.1136/bmj.i2416
   Daskalopoulou M, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0153838
   Dortland AKBV, 2010, ACTA PSYCHIAT SCAND, V122, P30, DOI 10.1111/j.1600-0447.2010.01565.x
   Dortland AKBV, 2013, PSYCHOSOM MED, V75, P83, DOI 10.1097/PSY.0b013e318274d30f
   Gan Y, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/s12888-014-0371-z
   Goldstein BI, 2015, CIRCULATION, V132, P965, DOI 10.1161/CIR.0000000000000229
   Havranek EP, 2015, CIRCULATION, V132, P873, DOI 10.1161/CIR.0000000000000228
   Huang CJ, 2013, INT J CARDIOL, V168, P4711, DOI 10.1016/j.ijcard.2013.07.173
   Jung-Choi K, 2011, J EPIDEMIOL COMMUN H, V65, P632, DOI 10.1136/jech.2009.100651
   Kanjilal S, 2006, ARCH INTERN MED, V166, P2348, DOI 10.1001/archinte.166.21.2348
   Kaptoge S, 2010, LANCET, V375, P132, DOI 10.1016/S0140-6736(09)61717-7
   Kerr GD, 2011, CEREBROVASC DIS, V31, P57, DOI 10.1159/000320855
   Khang YH, 2010, INT J EPIDEMIOL, V39, P1656, DOI 10.1093/ije/dyq117
   Kollia N, 2017, MATURITAS, V106, P73, DOI 10.1016/j.maturitas.2017.09.005
   Ladwig KH, 2017, ATHEROSCLEROSIS, V257, P224, DOI 10.1016/j.atherosclerosis.2016.12.003
   Lamotte C, 2013, ATHEROSCLEROSIS, V228, P460, DOI 10.1016/j.atherosclerosis.2013.03.007
   Lazzarino AI, 2013, PSYCHOSOM MED, V75, P311, DOI 10.1097/PSY.0b013e3182898e6d
   Lazzarino AI, 2013, JAMA INTERN MED, V173, P22, DOI 10.1001/2013.jamainternmed.951
   Manrique-Garcia E, 2011, J EPIDEMIOL COMMUN H, V65, P301, DOI 10.1136/jech.2009.104075
   Marshall IJ, 2015, LANCET NEUROL, V14, P1206, DOI 10.1016/S1474-4422(15)00200-8
   McLachlan KJJ, 2018, J PSYCHOSOM RES, V109, P79, DOI 10.1016/j.jpsychores.2018.04.004
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Park RJ, 2015, EUR J CLIN NUTR, V69, P501, DOI 10.1038/ejcn.2014.247
   Penninx BWJH, 2017, NEUROSCI BIOBEHAV R, V74, P277, DOI 10.1016/j.neubiorev.2016.07.003
   Pizzi C, 2014, ATHEROSCLEROSIS, V233, P530, DOI 10.1016/j.atherosclerosis.2014.01.012
   Pizzi C, 2010, ATHEROSCLEROSIS, V212, P292, DOI 10.1016/j.atherosclerosis.2010.04.038
   Poole L, 2014, J PSYCHOSOM RES, V76, P34, DOI 10.1016/j.jpsychores.2013.10.019
   Schnohr P, 2015, EUR HEART J, V36, P1385, DOI 10.1093/eurheartj/ehv027
   Thurston RC, 2014, STROKE, V45, P954, DOI 10.1161/STROKEAHA.113.004162
   von Känel R, 2001, PSYCHOSOM MED, V63, P531, DOI 10.1097/00006842-200107000-00003
   Yun WJ, 2015, BMC PUBLIC HEALTH, V15, DOI 10.1186/s12889-015-1365-6
   Zhang YX, 2018, J CLIN NEUROSCI, V47, P1, DOI 10.1016/j.jocn.2017.09.022
NR 41
TC 23
Z9 27
U1 0
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD JUN
PY 2019
VL 121
BP 14
EP 23
DI 10.1016/j.jpsychores.2019.01.016
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA IB1RF
UT WOS:000470041600005
PM 30712815
DA 2025-06-11
ER

PT J
AU Kamari, Y
   Grossman, E
   Oron-Herman, M
   Peleg, E
   Shabtay, Z
   Shamiss, A
   Sharabi, Y
AF Kamari, Y.
   Grossman, E.
   Oron-Herman, M.
   Peleg, E.
   Shabtay, Z.
   Shamiss, A.
   Sharabi, Y.
TI Metabolic stress with a high carbohydrate diet increases adiponectin
   levels
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE adiponectin; metabolic syndrome; carbohydrates; diet
ID INDUCED INSULIN-RESISTANCE; ADIPOSE-SPECIFIC PROTEIN; LOW-CALORIE DIET;
   CIRCULATING ADIPONECTIN; GENE-EXPRESSION; BLOOD-PRESSURE; OBESE WOMEN;
   ASSOCIATION; RECEPTOR; SUCROSE
AB Background: Adiponectin is an adipose tissue-specific protein, which possesses anti-atherogenic and antidiabetic properties, yet its plasma levels are decreased in subjects with metabolic syndrome. Although high fat diet has been linked to hypoadiponectinemia, the effect of high-carbohydrate diet on adiponectin levels is not known. Therefore, we studied the effect of high-carbohydrate diet on adiponectin levels in the rat models of hypertension and insulin resistance.
   Methods: Rats were randomly assigned to the high carbohydrate diet [Sprague-Dawley rats with fructose enriched diet (SDR-F) and spontaneously hypertensive rats with sucrose enriched diet (SHR-S model)] or chow diet (Control group). Rats were followed for 6 weeks (SDR-F model) and 8 weeks (SHR-S model). Body weight, systolic blood pressure, plasma levels of glucose, insulin, triglycerides and adiponectin, were recorded.
   Results: Both models were associated with features of the metabolic syndrome, namely, high insulin levels, increased blood pressure and triglyceride levels. Plasma adiponectin levels did not change in the control groups. In contrast, adiponectin levels increased by 39 and 30% compared to baseline following four and six weeks of fructose enriched diet in SDR (from 3.3 +/- 0.2 to 4.5 +/- 0.4 and 4.3 +/- 0.2 mu g/ml, respectively, p < 0.05). Likewise, five and eight weeks of sucrose enriched diet in SHR, induced a 54 and 81% increase in adiponectin levels compared to baseline (from 4.2 +/- 0.3 to 6.3 +/- 0.3 and 7.3 +/- 0.5 mu g/ml, respectively, p < 0.01).
   Conclusion: Metabolic stress with a high-carbohydrate diet increases plasma levels of adiponectin. Further studies will elucidate whether this is a transitory compensatory mechanism or a sign of target organ resistance to adiponectin.
C1 Chaim Sheba Med Ctr, Hypertens Unit, IL-52621 Tel Hashomer, Israel.
   Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel.
   NINDS, NIH, Bethesda, MD 20892 USA.
C3 Chaim Sheba Medical Center; Tel Aviv University; Sackler Faculty of
   Medicine; National Institutes of Health (NIH) - USA; NIH National
   Institute of Neurological Disorders & Stroke (NINDS)
RP Kamari, Y (corresponding author), Chaim Sheba Med Ctr, Hypertens Unit, IL-52621 Tel Hashomer, Israel.
EM yehuda.kamari@sheba.health.gov.il
OI Grossman, Ehud/0000-0001-8353-0661
CR Ackerman Z, 2005, HYPERTENSION, V45, P1012, DOI 10.1161/01.HYP.0000164570.20420.67
   Arita Y, 1999, BIOCHEM BIOPH RES CO, V257, P79, DOI 10.1006/bbrc.1999.0255
   Bauche IB, 2006, BIOCHEM BIOPH RES CO, V345, P1414, DOI 10.1016/j.bbrc.2006.05.033
   Combs TP, 2004, ENDOCRINOLOGY, V145, P367, DOI 10.1210/en.2003-1068
   Elkayam A, 2003, AM J HYPERTENS, V16, P1053, DOI 10.1016/j.amjhyper.2003.07.011
   ELZEIN M, 1990, AM J HYPERTENS, V3, P380
   Erlich Y., 1995, Clinical and Experimental Pharmacology and Physiology, V22, pS347, DOI 10.1111/j.1440-1681.1995.tb02949.x
   Gaby AR, 2005, ALTERN MED REV, V10, P294
   Garaulet M, 2004, J CLIN ENDOCR METAB, V89, P756, DOI 10.1210/jc.2003-031495
   Gross LS, 2004, AM J CLIN NUTR, V79, P774
   Heidemann C, 2005, DIABETOLOGIA, V48, P1126, DOI 10.1007/s00125-005-1743-1
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Hotta K, 2000, ARTERIOSCL THROM VAS, V20, P1595, DOI 10.1161/01.ATV.20.6.1595
   Hu E, 1996, J BIOL CHEM, V271, P10697, DOI 10.1074/jbc.271.18.10697
   Kasim-Karakas SE, 2006, AM J CLIN NUTR, V83, P774, DOI 10.1093/ajcn/83.4.774
   Koteish A, 2001, SEMIN LIVER DIS, V21, P89, DOI 10.1055/s-2001-12932
   Kubota N, 2002, J BIOL CHEM, V277, P25863, DOI 10.1074/jbc.C200251200
   Kumada M, 2004, CIRCULATION, V109, P2046, DOI 10.1161/01.CIR.0000127953.98131.ED
   Kumada M, 2003, ARTERIOSCL THROM VAS, V23, P85, DOI 10.1161/01.ATV.0000048856.22331.50
   Li JP, 2002, AM J PHYSIOL-ENDOC M, V282, pE1334, DOI 10.1152/ajpendo.00516.2001
   Li ZP, 2005, HEPATOLOGY, V42, P880, DOI 10.1002/hep.20826
   Liu YF, 2007, ENDOCRINOLOGY, V148, P683, DOI 10.1210/en.2006-0708
   Liu YM, 2003, J CLIN ENDOCR METAB, V88, P5881, DOI 10.1210/jc.2003-030886
   Maeda N, 2002, NAT MED, V8, P731, DOI 10.1038/nm724
   Matsuzawa Y, 2004, ARTERIOSCL THROM VAS, V24, P29, DOI 10.1161/01.ATV.0000099786.99623.EF
   McLellan F, 2002, LANCET, V359, P1412, DOI 10.1016/S0140-6736(02)08397-6
   OSSI AS, 2005, AM J PHYSIOL-REG I, V289, pR486
   Ouchi N, 2003, HYPERTENSION, V42, P231, DOI 10.1161/01.HYP.0000083488.67550.B8
   Pischon T, 2005, AM J CLIN NUTR, V81, P780, DOI 10.1093/ajcn/81.4.780
   Pitre M, 1996, AM J PHYSIOL-ENDOC M, V271, pE658, DOI 10.1152/ajpendo.1996.271.4.E658
   Polson DA, 2004, J NUTR BIOCHEM, V15, P242, DOI 10.1016/j.nutbio.2003.11.009
   Qi L, 2005, DIABETES CARE, V28, P1022, DOI 10.2337/diacare.28.5.1022
   Ran JM, 2006, METABOLISM, V55, P478, DOI 10.1016/j.metabol.2005.10.009
   Sato T, 1996, CLIN EXP PHARMACOL P, V23, P669, DOI 10.1111/j.1440-1681.1996.tb01755.x
   Shimomura Iichiro, 2002, Tanpakushitsu Kakusan Koso, V47, P1896
   Trujillo ME, 2005, J INTERN MED, V257, P167, DOI 10.1111/j.1365-2796.2004.01426.x
   Uchida A, 1997, LIFE SCI, V61, P455, DOI 10.1016/S0024-3205(97)00403-7
   Xi L, 2007, J NUTR BIOCHEM, V18, P64, DOI 10.1016/j.jnutbio.2006.03.010
   Xydakis AM, 2004, J CLIN ENDOCR METAB, V89, P2697, DOI 10.1210/jc.2003-031826
   Yamauchi T, 2003, J BIOL CHEM, V278, P2461, DOI 10.1074/jbc.M209033200
   Yamauchi T, 2001, NAT MED, V7, P941, DOI 10.1038/90984
   Yamauchi Toshimasa, 2003, Current Drug Targets - Immune Endocrine and Metabolic Disorders, V3, P243, DOI 10.2174/1568008033340090
   Yannakoulia M, 2003, J CLIN ENDOCR METAB, V88, P1730, DOI 10.1210/jc.2002-021604
   ZAVARONI I, 1982, METABOLISM, V31, P1077, DOI 10.1016/0026-0495(82)90155-X
   ZHANG YY, 1994, NATURE, V372, P425, DOI 10.1038/372425a0
   Zhu M, 2004, EXP GERONTOL, V39, P1049, DOI 10.1016/j.exger.2004.03.024
NR 46
TC 38
Z9 43
U1 0
U2 10
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD MAY
PY 2007
VL 39
IS 5
BP 384
EP 388
DI 10.1055/s-2007-976534
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 179CX
UT WOS:000247268000012
PM 17533582
DA 2025-06-11
ER

PT J
AU Gulley, LD
   Shomaker, LB
   Kelly, NR
   Chen, KY
   Olsen, CH
   Tanofsky-Kraff, M
   Yanovski, JA
AF Gulley, Lauren D.
   Shomaker, Lauren B.
   Kelly, Nichole R.
   Chen, Kong Y.
   Olsen, Cara H.
   Tanofsky-Kraff, Marian
   Yanovski, Jack A.
TI Examining cognitive-behavioral therapy change mechanisms for decreasing
   depression, weight, and insulin resistance in adolescent girls at risk
   for type 2 diabetes
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Adolescent psychotherapy; Depression (emotion); Metabolic syndrome;
   Obesity; Randomized controlled trials
ID PREVENTION PROGRAM; SYMPTOMS; ACTIVATION; TRIAL; POPULATION; VALIDATION;
   PARAMETERS; CHILDREN; GLUCOSE; OBESITY
AB Objective: Depression in adolescence is linked to risk for type 2 diabetes (T2D). In this secondary data analysis of a randomized controlled trial comparing cognitive-behavioral therapy (CBT) to a control program to ameliorate insulin resistance via reducing depression symptoms, we examine which CBT change mechanisms (e.g., behavioral activation, cognitive restructuring) contributed to decreased depression and subsequent improvements in body mass index (BMI), percent body fat, and insulin resistance. Methods: Girls 12-17y with overweight/obesity and family history of T2D were randomized to six-week group CBT (n = 61) or health education (HealthEd; n = 58). At baseline and post-treatment, adolescents completed questionnaires assessing activities, thoughts, and depression symptoms. At baseline, post-treatment, and one-year, BMI was calculated and insulin outcomes were derived from two-hour oral glucose tolerance testing. At baseline and one-year, percent body fat was assessed with dual-energy x-ray absorptiometry. Indirect effects of CBT components were tested on one-year changes in BMI, percent body fat, and insulin indices through decreases in depression symptoms during treatment. Intervention was tested as a moderator. Results: In CBT, but not HealthEd, there was an indirect effect of increased physical activity during treatment on decreased one-year BMI via reductions in depression symptoms during treatment. Also, there were conditional indirect effects in CBT of increased pleasantness of physical and social activity during treatment on decreased one-year BMI via decreased depression symptoms during treatment. Conclusion: Behavioral activation may be a useful intervention to decrease depression and reduce excess weight gain in the targeted prevention of T2D in at-risk adolescent girls. NCT01425905, clinicaltrials.gov
C1 [Gulley, Lauren D.; Shomaker, Lauren B.] Colorado State Univ, Human Dev & Family Studies, Campus Delivery 1570, Ft Collins, CO 80523 USA.
   [Gulley, Lauren D.; Shomaker, Lauren B.] Univ Colorado, Childrens Hosp Colorado, Pediat, Sect Endocrinol, Anschutz Med Campus,13123 E 16th Ave,B265, Aurora, CO 80045 USA.
   [Shomaker, Lauren B.; Kelly, Nichole R.; Tanofsky-Kraff, Marian; Yanovski, Jack A.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Growth & Obes, Div Intramural Res, NIH, 10 Ctr Dr, Bethesda, MD 20892 USA.
   [Kelly, Nichole R.] Univ Oregon, Coll Educ, Counseling Psychol & Human Serv & Prevent Sci Ins, 1215 Univ Oregon, Eugene, OR 97403 USA.
   [Chen, Kong Y.] NIDDK, Diabet Endocrinol & Obes Branch, NIH, 10 Ctr Dr, Bethesda, MD 20892 USA.
   [Olsen, Cara H.] Uniformed Serv Univ Hlth Sci, Preventat Med & Biometr, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
   [Tanofsky-Kraff, Marian] Uniformed Serv Univ Hlth Sci, Med & Clin Psychol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
C3 Colorado State University System; Colorado State University Fort
   Collins; Children's Hospital Colorado; University of Colorado System;
   University of Colorado Anschutz Medical Campus; National Institutes of
   Health (NIH) - USA; Division of Intramural Research (DIR); NIH Eunice
   Kennedy Shriver National Institute of Child Health & Human Development
   (NICHD); University of Oregon; National Institutes of Health (NIH) -
   USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases
   (NIDDK); Uniformed Services University of the Health Sciences - USA;
   Uniformed Services University of the Health Sciences - USA
RP Gulley, LD (corresponding author), 1570 Campus Delivery, Ft Collins, CO 80523 USA.
EM lauren.gulley@colostate.edu
RI Chen, Kong/L-6972-2017
OI Yanovski, Jack/0000-0001-8542-1637; Kelly, Nichole/0000-0003-0812-4182
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development (NICHD) [K99HD069516, R00HD069516]; National Institute of
   Health (NIH) Intramural Research Program Grant from NICHD
   [1ZIAHD000641]; NIH Bench to Bedside Program; Office of Behavioral &
   Social Sciences Research; NIH Office of Disease Prevention
FX This work was supported by the Eunice Kennedy Shriver National Institute
   of Child Health and Human Development (NICHD) (Grant #K99HD069516 and
   R00HD069516) ; the National Institute of Health (NIH) Intramural
   Research Program Grant from NICHD (Grant #1ZIAHD000641) to JAY, with
   supplemental funding from the NIH Bench to Bedside Program to LBS, MT-K,
   and JAY; Office of Behavioral & Social Sciences Research to JAY; and NIH
   Office of Disease Prevention to JAY.
CR Armey MF, 2015, CURR OPIN PSYCHOL, V4, P21, DOI 10.1016/j.copsyc.2015.01.002
   Bailey AP, 2018, PSYCHOL MED, V48, P1068, DOI 10.1017/S0033291717002653
   Bravender T., 2005, Health, Education, and Youth in Durham: HEY-Durham Curricular Guide, V2nd
   Brinkhues S, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4948-6
   Cuijpers P, 2007, CLIN PSYCHOL REV, V27, P318, DOI 10.1016/j.cpr.2006.11.001
   Gariépy G, 2016, BRIT J PSYCHIAT, V209, P286, DOI 10.1192/bjp.bp.115.169094
   Gulley LD, 2019, J PEDIATR PSYCHOL, V44, P1163, DOI 10.1093/jpepsy/jsz064
   Hales CM, 2018, JAMA-J AM MED ASSOC, V319, P1723, DOI 10.1001/jama.2018.3060
   Hannon TS, 2013, PEDIATR DIABETES, V14, P497, DOI 10.1111/pedi.12035
   Hayes A. F., 2017, INTRO MEDIATION MODE
   Hayes AF, 2020, AM BEHAV SCI, V64, P19, DOI 10.1177/0002764219859633
   Hayes Andrew F, 2017, Behav Res Ther, V98, P39, DOI 10.1016/j.brat.2016.11.001
   Hayes AF, 2015, MULTIVAR BEHAV RES, V50, P1, DOI 10.1080/00273171.2014.962683
   Hayes AF, 2009, COMMUN MONOGR, V76, P408, DOI 10.1080/03637750903310360
   HOLLON SD, 1980, COGNITIVE THER RES, V4, P383, DOI 10.1007/BF01178214
   Jelalian E, 2019, J CLIN CHILD ADOLESC, V48, pS24, DOI 10.1080/15374416.2016.1163705
   KAUTH MR, 1990, J CLIN PSYCHOL, V46, P291, DOI 10.1002/1097-4679(199005)46:3<291::AID-JCLP2270460307>3.0.CO;2-S
   Kelly AS, 2018, INT J OBESITY, V42, P1834, DOI 10.1038/s41366-018-0231-x
   Ko CY, 2015, PSYCHONEUROENDOCRINO, V55, P173, DOI 10.1016/j.psyneuen.2015.02.007
   LEWINSOHN PM, 1980, PSYCHOTHER-THEOR RES, V17, P322, DOI 10.1037/h0085929
   MACPHILLAMY DJ, 1982, J CONSULT CLIN PSYCH, V50, P363, DOI 10.1037/0022-006X.50.3.363
   Mannan M, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0157240
   Markowitz S, 2008, CLIN PSYCHOL-SCI PR, V15, P1, DOI 10.1111/j.1468-2850.2008.00106.x
   Marmorstein NR, 2014, INT J OBESITY, V38, P906, DOI 10.1038/ijo.2014.19
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mayer-Davis EJ, 2017, NEW ENGL J MED, V376, P1419, DOI 10.1056/NEJMoa1610187
   McCauley E, 2016, J CLIN CHILD ADOLESC, V45, P291, DOI 10.1080/15374416.2014.979933
   Moulton CD, 2015, LANCET DIABETES ENDO, V3, P461, DOI 10.1016/S2213-8587(15)00134-5
   Ogden CL, 2002, PEDIATRICS, V109, P45, DOI 10.1542/peds.109.1.45
   Oud M, 2019, EUR PSYCHIAT, V57, P33, DOI 10.1016/j.eurpsy.2018.12.008
   Phillips GA, 2006, MULTIVAR BEHAV RES, V41, P147, DOI 10.1207/s15327906mbr4102_3
   Preacher KJ, 2004, BEHAV RES METH INS C, V36, P717, DOI 10.3758/BF03206553
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   RUSH AJ, 1978, AM J PSYCHOTHER, V32, P201, DOI 10.1176/appi.psychotherapy.1978.32.2.201
   Schoemann AM, 2017, SOC PSYCHOL PERS SCI, V8, P379, DOI 10.1177/1948550617715068
   Selig JP, 2009, RES HUM DEV, V6, P144, DOI 10.1080/15427600902911247
   Shomaker LB, 2017, DEPRESS ANXIETY, V34, P866, DOI 10.1002/da.22617
   Shomaker LB, 2016, ANN BEHAV MED, V50, P762, DOI 10.1007/s12160-016-9801-0
   Shomaker LB, 2011, DIABETES CARE, V34, P2458, DOI 10.2337/dc11-1131
   Stice E, 2008, J CONSULT CLIN PSYCH, V76, P595, DOI 10.1037/a0012645
   Stice E, 2007, BEHAV RES THER, V45, P863, DOI 10.1016/j.brat.2006.08.008
   Stice E, 2010, J CONSULT CLIN PSYCH, V78, P856, DOI 10.1037/a0020544
   Stice E, 2010, J CONSULT CLIN PSYCH, V78, P273, DOI 10.1037/a0018396
   Takagaki K, 2016, J AFFECT DISORDERS, V204, P70, DOI 10.1016/j.jad.2016.06.046
   Tindall L, 2017, PSYCHOL PSYCHOTHER-T, V90, P770, DOI 10.1111/papt.12121
   van den Heuvel MWH, 2019, BMC PSYCHIATRY, V19, DOI 10.1186/s12888-019-2168-6
   Webb CA, 2012, J CLIN CHILD ADOLESC, V41, P654, DOI 10.1080/15374416.2012.704842
   Whisman MA, 2010, HEALTH PSYCHOL, V29, P550, DOI 10.1037/a0020760
   Yeckel CW, 2004, J CLIN ENDOCR METAB, V89, P1096, DOI 10.1210/jc.2003-031503
NR 49
TC 8
Z9 9
U1 1
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD JUN
PY 2022
VL 157
AR 110781
DI 10.1016/j.jpsychores.2022.110781
EA MAR 2022
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 1C6UW
UT WOS:000793252500006
PM 35367918
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Lucka, A
   Arabska, J
   Fife, E
   Kroc, L
   Soltysik, BK
   Kloszewska, I
   Sobów, T
   Kostka, T
   Wysokinski, A
AF Lucka, Anna
   Arabska, Jasmina
   Fife, Elizaveta
   Kroc, Lukasz
   Soltysik, Bartlomiej Konrad
   Kloszewska, Iwona
   Sobow, Tomasz
   Kostka, Tomasz
   Wysokinski, Adam
TI Atherogenic Indices Are Increased in Elderly Patients with Unipolar
   Depression-Case-Control Analysis
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE lipids; cholesterol; triglycerides; atherogenic indices; depression; old
   age psychiatry
ID LATE-LIFE DEPRESSION; MAJOR DEPRESSION; LIPID-LEVELS;
   DENSITY-LIPOPROTEIN; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   SERUM-CHOLESTEROL; MOOD DISORDERS; SYMPTOMS; ASSOCIATION
AB Background: Blood lipids are widely used in monitoring the risk of cardiovascular diseases; however, atherogenic indices are more precise markers. The aim of the study was to determine differences in atherogenic indices in elderly patients with unipolar depression (DEP) compared with nondepressed elderly patients (nonDEP) using case-control analysis.
   Methods: Fasting serum lipid profiles were measured in 564 (depressed: n = 282, nondepressed: n = 282, 83.7% (n = 236) women in both groups) Caucasian inpatients aged >= 60, with mean age 76.9 years. Patients from both groups were matched for age and sex. Atherogenic index of plasma (AIP) was calculated as log(10)(triglycerides/ HDL cholesterol). Castelli atherogenic indices were calculated as follows: AILDL/HDL is the ratio of low-density lipoprotein (LDL) cholesterol to high-density lipoprotein (HDL) cholesterol and AI(TC/HDL) is the ratio of total cholesterol to HDL cholesterol.
   Results: HDL levels were significantly decreased in depressed patients (48.2 +/- 14.4mg/dL vs. 54.5 +/- 17.7mg/dL). No other differences in lipid profile were found. We found that all three analyzed atherogenic indices were increased in depressed patients (AIP: 0.41 +/- 0.28 vs. 0.33 +/- 0.27, AI(LDL/HDL): 2.90 +/- 1.41 vs. 2.42 +/- 1.07, AI(TC/HDL): 4.51 +/- 1.84 vs. 3.79 +/- 1.21). We found associations between depression severity and reduced level of HDL (beta=-0.02) or increased AIP (beta = 1.66).
   Conclusions: All three atherogenic indices were increased in elderly patients with depression. Since depression and age are associated with elevated risk of cardiovascular events, elderly patients with depression should be carefully monitored for abnormal lipid status to reduce their cardiovascular risk. The role of lipid abnormalities in the pathogenesis of depression requires further studies.
C1 [Lucka, Anna; Arabska, Jasmina; Kloszewska, Iwona; Wysokinski, Adam] Med Univ Lodz, Dept Old Age Psychiat & Psychot Disorders, Czechoslowacka 8-10, PL-92216 Lodz, Poland.
   [Fife, Elizaveta; Kroc, Lukasz; Soltysik, Bartlomiej Konrad; Kostka, Tomasz] Med Univ Lodz, Dept Geriatr, Lodz, Poland.
   [Sobow, Tomasz] Med Univ Lodz, Dept Med Psychol, Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz; Medical University
   Lodz
RP Wysokinski, A (corresponding author), Med Univ Lodz, Dept Old Age Psychiat & Psychot Disorders, Czechoslowacka 8-10, PL-92216 Lodz, Poland.
EM adam.wysokinski@umed.lodz.pl
RI Wysokinski, Adam/S-9294-2016; Wysokinski, Adam/G-8174-2014; Soltysik,
   Bartlomiej K./S-9839-2016
OI Fife, Elizaveta/0000-0002-4316-4801; Wysokinski,
   Adam/0000-0002-6159-6579; Soltysik, Bartlomiej K./0000-0002-1382-3757;
   Kostka, Tomasz/0000-0003-0437-650X
CR Äijänseppä S, 2002, INT J GERIATR PSYCH, V17, P629, DOI 10.1002/gps.666
   Ancelin ML, 2010, BIOL PSYCHIAT, V68, P125, DOI 10.1016/j.biopsych.2010.04.011
   Beydoun MA, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.4
   Bortolasci CC, 2015, J AFFECT DISORDERS, V179, P148, DOI 10.1016/j.jad.2015.03.041
   Boscarino JA, 2009, J PSYCHIATR RES, V43, P848, DOI 10.1016/j.jpsychires.2008.11.007
   Brehm A, 2004, CLIN CHEM, V50, P2316, DOI 10.1373/clinchem.2004.037556
   Brigitta Bondy, 2002, Dialogues Clin Neurosci, V4, P7
   BROWN SL, 1994, BRIT MED J, V308, P1328, DOI 10.1136/bmj.308.6940.1328
   CASTELLI WP, 1983, CIRCULATION, V67, P730, DOI 10.1161/01.CIR.67.4.730
   Comijs HC, 2015, BMC PSYCHIATRY, V15, DOI 10.1186/s12888-015-0401-5
   CRUM RM, 1993, JAMA-J AM MED ASSOC, V269, P2386, DOI 10.1001/jama.269.18.2386
   De Bem A, 2014, FREE RADICAL BIO MED, V75, pS28, DOI 10.1016/j.freeradbiomed.2014.10.753
   De Berardis D, 2009, J BIOL REG HOMEOS AG, V23, P133
   Dobiasova M, 2006, Vnitr Lek, V52, P64
   Dortland AKBV, 2010, J CLIN PSYCHIAT, V71, P729, DOI 10.4088/JCP.08m04865blu
   Halaris A, 2017, CURR TOP BEHAV NEURO, V31, P45, DOI 10.1007/7854_2016_28
   Huang TL, 2005, J AFFECT DISORDERS, V86, P75, DOI 10.1016/j.jad.2004.11.005
   Huang TL, 2003, PSYCHIAT RES, V118, P147, DOI 10.1016/S0165-1781(03)00071-4
   Kanter JW, 2008, BEHAV ANALYST, V31, P1
   Kim JM, 2006, BRIT J PSYCHIAT, V189, P26, DOI 10.1192/bjp.bp.105.015032
   Kim JM, 2004, BRIT J PSYCHIAT, V185, P102, DOI 10.1192/bjp.185.2.102
   Lehto SM, 2008, PROG NEURO-PSYCHOPH, V32, P1557, DOI 10.1016/j.pnpbp.2008.05.021
   Liang YJ, 2014, INT J BEHAV MED, V21, P590, DOI 10.1007/s12529-013-9358-2
   Mangerud WL, 2014, J ADOLESCENCE, V37, P1189, DOI 10.1016/j.adolescence.2014.08.007
   Marc LG, 2008, AM J GERIAT PSYCHIAT, V16, P914, DOI 10.1097/JGP.0b013e318186bd67
   Olusi SO, 1996, BIOL PSYCHIAT, V40, P1128, DOI 10.1016/S0006-3223(95)00599-4
   Onat A, 2010, J CLIN LIPIDOL, V4, P89, DOI 10.1016/j.jacl.2010.02.005
   Papakostas GI, 2004, EUR NEUROPSYCHOPHARM, V14, P135, DOI 10.1016/S0924-977X(03)00099-3
   Park YMM, 2015, J AM COLL CARDIOL, V65, P2091, DOI 10.1016/j.jacc.2015.03.517
   Partonen T, 1999, BRIT J PSYCHIAT, V175, P259, DOI 10.1192/bjp.175.3.259
   Persons JE, 2016, J AFFECT DISORDERS, V206, P55, DOI 10.1016/j.jad.2016.07.033
   Pittenger C, 2008, NEUROPSYCHOPHARMACOL, V33, P88, DOI 10.1038/sj.npp.1301574
   Sagud M, 2009, PSYCHIAT RES, V168, P218, DOI 10.1016/j.psychres.2008.06.048
   Shin HY, 2016, PSYCHIAT RES, V241, P172, DOI 10.1016/j.psychres.2016.05.003
   Tedders SH, 2011, J AFFECT DISORDERS, V135, P115, DOI 10.1016/j.jad.2011.06.045
   Tyrovolas S, 2009, LIPIDS HEALTH DIS, V8, DOI 10.1186/1476-511X-8-10
   Vargas HO, 2014, LIFE SCI, V102, P65, DOI 10.1016/j.lfs.2014.02.033
   Nunes SOV, 2015, J AFFECT DISORDERS, V172, P55, DOI 10.1016/j.jad.2014.09.038
   Vilhelmsson A, 2014, FRONT PUBLIC HEALTH, V2, DOI 10.3389/fpubh.2014.00192
   Wang JM, 2016, COMPR PSYCHIAT, V69, P163, DOI 10.1016/j.comppsych.2016.05.005
   Wu SQ, 2016, J PSYCHIATR NEUROSCI, V41, P56, DOI 10.1503/jpn.150079
   Zhu XW, 2015, PRIM CARE DIABETES, V9, P60, DOI 10.1016/j.pcd.2014.03.007
NR 42
TC 8
Z9 8
U1 1
U2 8
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD AUG
PY 2017
VL 15
IS 6
BP 291
EP 295
DI 10.1089/met.2017.0008
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA FB9MU
UT WOS:000406464000007
PM 28402173
DA 2025-06-11
ER

PT J
AU Hanefeld, M
   Pistrosch, F
   Bornstein, SR
   Birkenfeld, AL
AF Hanefeld, Markolf
   Pistrosch, Frank
   Bornstein, Stefan R.
   Birkenfeld, Andreas L.
TI The metabolic vascular syndrome - guide to an individualized treatment
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Review
DE Metabolic syndrome; Type 2 diabetes; Treatment; OAD
ID TYPE-2 DIABETES-MELLITUS; CARDIOVASCULAR RISK-FACTORS; HEPATIC
   INSULIN-RESISTANCE; BARIATRIC SURGERY; ADIPOSE-TISSUE; DOUBLE-BLIND;
   ENDOTHELIAL DYSFUNCTION; MYOCARDIAL-INFARCTION; NATRIURETIC PEPTIDES;
   SECONDARY PREVENTION
AB In ancient Greek medicine the concept of a distinct syndrome (going together) was used to label 'a group of signs and symptoms' that occur together and 'characterize a particular abnormality and condition'. The (dys)metabolic syndrome is a common cluster of five pre-morbid metabolic-vascular risk factors or diseases associated with increased cardiovascular morbidity, fatty liver disease and risk of cancer. The risk for major complications such as cardiovascular diseases, NASH and some cancers develops along a continuum of risk factors into clinical diseases. Therefore we still include hyperglycemia, visceral obesity, dyslipidemia and hypertension as diagnostic traits in the definition according to the term 'deadly quartet'. From the beginning elevated blood pressure and hyperglycemia were core traits of the metabolic syndrome associated with endothelial dysfunction and increased risk of cardiovascular disease. Thus metabolic and vascular abnormalities are in extricable linked. Therefore it seems reasonable to extend the term to metabolic-vascular syndrome (MVS) to signal the clinical relevance and related risk of multimorbidity. This has important implications for integrated diagnostics and therapeutic approach. According to the definition of a syndrome the rapid global rise in the prevalence of all traits and comorbidities of the MVS is mainly caused by rapid changes in life-style and sociocultural transition resp. with over- and malnutrition, low physical activity and social stress as a common soil.
C1 [Hanefeld, Markolf; Pistrosch, Frank; Birkenfeld, Andreas L.] GWT TU Dresden GmbH, Fiedlerstr 34, D-01307 Dresden, Germany.
   [Hanefeld, Markolf; Pistrosch, Frank; Bornstein, Stefan R.; Birkenfeld, Andreas L.] Univ Klinikum Carl Gustav Carus, Med Klin 3, Fetscherstr 74, D-01307 Dresden, Germany.
   [Bornstein, Stefan R.; Birkenfeld, Andreas L.] Kings Coll London, Rayne Inst, Sect Diabet & Nutr Sci, Denmark Hill Campus, London, England.
   [Bornstein, Stefan R.; Birkenfeld, Andreas L.] Tech Univ Dresden, Univ Hosp, Paul Langerhans Inst Dresden, Helmholtz Ctr Munich, Dresden, Germany.
   [Bornstein, Stefan R.; Birkenfeld, Andreas L.] Tech Univ Dresden, Fac Med, Dresden, Germany.
   [Bornstein, Stefan R.; Birkenfeld, Andreas L.] German Ctr Diabet Res DZD eV, Neuherberg, Germany.
C3 Technische Universitat Dresden; Technische Universitat Dresden; Carl
   Gustav Carus University Hospital; University of London; King's College
   London; Technische Universitat Dresden; Carl Gustav Carus University
   Hospital; Helmholtz Association; Helmholtz-Center Munich - German
   Research Center for Environmental Health; Technische Universitat
   Dresden; German Center for Diabetes Research (DZD)
RP Birkenfeld, AL (corresponding author), GWT TU Dresden GmbH, Fiedlerstr 34, D-01307 Dresden, Germany.; Birkenfeld, AL (corresponding author), Univ Klinikum Carl Gustav Carus, Med Klin 3, Fetscherstr 74, D-01307 Dresden, Germany.; Birkenfeld, AL (corresponding author), Kings Coll London, Rayne Inst, Sect Diabet & Nutr Sci, Denmark Hill Campus, London, England.; Birkenfeld, AL (corresponding author), Tech Univ Dresden, Univ Hosp, Paul Langerhans Inst Dresden, Helmholtz Ctr Munich, Dresden, Germany.; Birkenfeld, AL (corresponding author), Tech Univ Dresden, Fac Med, Dresden, Germany.; Birkenfeld, AL (corresponding author), German Ctr Diabet Res DZD eV, Neuherberg, Germany.
EM andreas.birkenfeld@uniklinikum-dresden.de
RI Birkenfeld, Andreas/U-3954-2019; Pistrosch, Frank/J-1398-2019
OI Birkenfeld, Andreas/0000-0003-1407-9023
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   [Anonymous], REV ENDOCR METAB DIS
   [Anonymous], LANCET
   [Anonymous], 2006, J ANAL TOXICOL
   [Anonymous], ZENTRALBLATT INN MED
   Apovian CM, 2016, NEW ENGL J MED, V374, P177, DOI 10.1056/NEJMe1514957
   Armstrong MJ, 2016, LANCET, V387, P679, DOI 10.1016/S0140-6736(15)00803-X
   Assmann G, 2007, EUR J CLIN INVEST, V37, P925, DOI 10.1111/j.1365-2362.2007.01888.x
   Ataoglu HE, 2009, J DIABETES, V1, P188, DOI 10.1111/j.1753-0407.2009.00032.x
   AVOGARO P, 1961, PANMINERVA MED, V3, P574
   Baigent C, 2010, LANCET, V376, P1670, DOI 10.1016/S0140-6736(10)61350-5
   Bakris GL, 2010, LANCET, V375, P1173, DOI 10.1016/S0140-6736(09)62100-0
   Bakris GL, 2004, JAMA-J AM MED ASSOC, V292, P2227, DOI 10.1001/jama.292.18.2227
   Barrès R, 2012, CELL METAB, V15, P405, DOI 10.1016/j.cmet.2012.01.001
   Barter PJ, 2007, NEW ENGL J MED, V357, P2109, DOI 10.1056/NEJMoa0706628
   Batsis JA, 2008, MAYO CLIN PROC, V83, P897, DOI 10.4065/83.8.897
   BERINGER A, 1970, DEUT MED WOCHENSCHR, V95, P836, DOI 10.1055/s-0028-1108549
   Bhatt DL, 2002, AM J CARDIOL, V90, P625, DOI 10.1016/S0002-9149(02)02567-5
   Birkenfeld AL, 2014, HEPATOLOGY, V59, P713, DOI 10.1002/hep.26672
   Birkenfeld AL, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043238
   Birkenfeld AL, 2011, HYPERTENSION, V57, pE4, DOI 10.1161/HYPERTENSIONAHA.110.165159
   Boden WE, 2011, NEW ENGL J MED, V365, P2255, DOI 10.1056/NEJMoa1107579
   Bosch J, 2006, NEW ENGL J MED, V355, P1551
   Bouloumié A, 2008, ARTERIOSCL THROM VAS, V28, P1211, DOI 10.1161/ATVBAHA.108.168229
   Burgess DC, 2010, EUR HEART J, V31, P92, DOI 10.1093/eurheartj/ehp377
   Cannon CP, 2015, NEW ENGL J MED, V372, P2387, DOI 10.1056/NEJMoa1410489
   Catapano AL, 2011, ATHEROSCLEROSIS, V217, P3, DOI 10.1016/j.atherosclerosis.2011.06.028
   Celik T, 2006, J HYPERTENS, V24, P591, DOI 10.1097/01.hjh.0000209993.26057.de
   Charles MA, 2000, DIABETES-METAB RES, V16, P2, DOI 10.1002/(SICI)1520-7560(200001/02)16:1<2::AID-DMRR75>3.0.CO;2-G
   Chiasson JL, 2002, LANCET, V359, P2072, DOI 10.1016/S0140-6736(02)08905-5
   Chiasson JL, 2003, JAMA-J AM MED ASSOC, V290, P486, DOI 10.1001/jama.290.4.486
   Claussnitzer M, 2015, NEW ENGL J MED, V373, P895, DOI 10.1056/NEJMoa1502214
   Clemente JC, 2015, SCI ADV, V1, DOI 10.1126/sciadv.1500183
   Collins R, 2009, LANCET, V373, P1849, DOI 10.1016/S0140-6736(09)60503-1
   Cornier MA, 2008, ENDOCR REV, V29, P777, DOI 10.1210/er.2008-0024
   Cotillard A, 2013, NATURE, V500, P585, DOI 10.1038/nature12480
   Cypess AM, 2009, NEW ENGL J MED, V360, P1509, DOI 10.1056/NEJMoa0810780
   Dastani Z., 2012, PLOS GENET, V8
   Davidson MH, 2007, AM J CARDIOL, V99, p3C, DOI 10.1016/j.amjcard.2006.11.016
   DEFRONZO RA, 1979, AM J PHYSIOL, V237, pE214
   DeFronzo RA, 2013, DIABETES, V62, P3920, DOI 10.2337/db13-0265
   Donahoe SM, 2007, JAMA-J AM MED ASSOC, V298, P765, DOI 10.1001/jama.298.7.765
   Du XL, 2006, J CLIN INVEST, V116, P1071, DOI 10.1172/JCI23354
   Elliott WJ, 2007, LANCET, V369, P201, DOI 10.1016/S0140-6736(07)60108-1
   Estruch R, 2013, NEW ENGL J MED, V368, P1279, DOI 10.1056/NEJMoa1200303
   Ferrannini E, 1997, DIABETES METAB REV, V13, P81
   Fraga MF, 2005, P NATL ACAD SCI USA, V102, P10604, DOI 10.1073/pnas.0500398102
   Gawaz M, 2005, J CLIN INVEST, V115, P3378, DOI 10.1172/JCI27196
   Gerstein HC, 2011, DIABETOLOGIA, V54, P487, DOI 10.1007/s00125-010-1985-4
   Gerstein HC, 2012, NEW ENGL J MED, V367, P319, DOI 10.1056/NEJMoa1203858
   Gilbert RE, 2015, LANCET, V385, P2107, DOI 10.1016/S0140-6736(14)61402-1
   Green JB, 2015, NEW ENGL J MED, V373, P232, DOI 10.1056/NEJMoa1501352
   Grundy SM, 2007, J CLIN ENDOCR METAB, V92, P399, DOI 10.1210/jc.2006-0513
   Grundy SM, 2012, J AM COLL CARDIOL, V59, P635, DOI 10.1016/j.jacc.2011.08.080
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Gutierrez MJ, 2014, ARTERIOSCL THROM VAS, V34, P676, DOI 10.1161/ATVBAHA.113.302677
   Hanefeld M, 2004, EUR HEART J, V25, P10, DOI 10.1016/S0195-668X(03)00468-8
   HANEFELD M, 1981, DEUT GESUNDHEITSWES, V36, P545
   Hanefeld M, 2007, CARDIOVASC DIABETOL, V6, DOI 10.1186/1475-2840-6-13
   Hanefeld M, 2007, J AM COLL CARDIOL, V49, P290, DOI 10.1016/j.jacc.2006.08.054
   Hanefeld M, 2012, J HYPERTENS, V30, P1440, DOI 10.1097/HJH.0b013e328354663c
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Inabnet WB, 2012, J AM COLL SURGEONS, V214, P550, DOI 10.1016/j.jamcollsurg.2011.12.019
   Inge TH, 2016, NEW ENGL J MED, V374, P113, DOI 10.1056/NEJMoa1506699
   Isomaa B, 2001, DIABETOLOGIA, V44, P1148, DOI 10.1007/s001250100615
   JAHNKE K, 1964, KLIN WOCHENSCHR, V42, P1016, DOI 10.1007/BF01479445
   Jamerson K, 2008, NEW ENGL J MED, V359, P2417, DOI 10.1056/NEJMoa0806182
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   Keyhani-Nejad F, 2015, DIABETOLOGIA, V58, P374, DOI 10.1007/s00125-014-3423-5
   Khazanie P, 2015, AM HEART J, V170, P290, DOI 10.1016/j.ahj.2015.04.006
   Knowler William C, 2002, N Engl J Med, V346, P393, DOI 10.1056/NEJMoa012512
   Koch CA, 1997, ARCH INTERN MED, V157, P2668, DOI 10.1001/archinte.1997.00440430150028
   Kristensen SL, 2016, CIRC-HEART FAIL, P9
   Kumashiro N, 2013, DIABETES, V62, P2183, DOI 10.2337/db12-1311
   Kung J, 2012, EXPERT OPIN DRUG SAF, V11, P565, DOI 10.1517/14740338.2012.691963
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Lehman SJ, 2010, ATHEROSCLEROSIS, V210, P656, DOI 10.1016/j.atherosclerosis.2010.01.007
   Luyckx VA, 2013, LANCET, V382, P273, DOI 10.1016/S0140-6736(13)60311-6
   Mancia G, 2013, J HYPERTENS, V31, P1281, DOI 10.1097/01.hjh.0000431740.32696.cc
   Maranon G., 1922, ZENTRALBLATT INNERE, V43, P169
   McMurray JJ, 2010, NEW ENGL J MED, V362, P1477, DOI 10.1056/NEJMoa1001121
   McMurray JJV, 2014, NEW ENGL J MED, V371, P993, DOI 10.1056/NEJMoa1409077
   Mehnert H, 1968, Dtsch Med J, V19, P567
   Meijer RI, 2013, DIABETES, V62, P590, DOI 10.2337/db11-1603
   Melcescu E, 2012, HORM-INT J ENDOCRINO, V11, P166, DOI 10.14310/horm.2002.1344
   Mente A, 2009, ARCH INTERN MED, V169, P659, DOI 10.1001/archinternmed.2009.38
   Neeland IJ, 2012, JAMA-J AM MED ASSOC, V308, P1150, DOI 10.1001/2012.jama.11132
   Ooi EMM, 2008, DIABETES CARE, V31, P1656, DOI 10.2337/dc08-0358
   Orchard TJ, 2013, DIABETIC MED, V30, P46, DOI 10.1111/j.1464-5491.2012.03750.x
   Patel V, 2013, CAN J PHYSIOL PHARM, V91, P1009, DOI 10.1139/cjpp-2013-0189
   Payne GA, 2010, ARTERIOSCL THROM VAS, V30, P1711, DOI 10.1161/ATVBAHA.110.210070
   Perry RJ, 2015, CELL, V160, P745, DOI 10.1016/j.cell.2015.01.012
   Pervanidou P, 2012, METABOLISM, V61, P611, DOI 10.1016/j.metabol.2011.10.005
   Pfeffer MA, 2015, NEW ENGL J MED, V373, P2247, DOI 10.1056/NEJMoa1509225
   Pi-Sunyer X, 2015, NEW ENGL J MED, V373, P11, DOI 10.1056/NEJMoa1411892
   Pinkosky SL, 2013, J LIPID RES, V54, P134, DOI 10.1194/jlr.M030528
   Pistrosch F, 2005, DIABETES, V54, P2206, DOI 10.2337/diabetes.54.7.2206
   Pistrosch F, 2004, DIABETES CARE, V27, P484, DOI 10.2337/diacare.27.2.484
   Pistrosch F, 2012, HORM METAB RES, V44, P914, DOI 10.1055/s-0032-1314836
   Poirier P, 2011, CIRCULATION, V123, P1683, DOI 10.1161/CIR.0b013e3182149099
   Preiss D, 2011, JAMA-J AM MED ASSOC, V305, P2556, DOI 10.1001/jama.2011.860
   Ramos HR, 2015, ENDOCR CONNECT, V4, pR25, DOI 10.1530/EC-15-0018
   Randriamboavonjy V, 2012, CURR VASC PHARMACOL, V10, P532, DOI 10.2174/157016112801784639
   REAVEN GM, 1993, ANNU REV MED, V44, P121, DOI 10.1146/annurev.med.44.1.121
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Rebrin K, 1996, J CLIN INVEST, V98, P741, DOI 10.1172/JCI118846
   Rosenson RS, 2009, DIABETES CARE, V32, P1087, DOI 10.2337/dc08-1681
   Rudofsky G Jr, 2004, HORM METAB RES, V36, P630, DOI 10.1005/s-2004-825904
   Rutter MK, 2003, CIRCULATION, V107, P448, DOI 10.1161/01.CIR.0000045671.62860.98
   Sattar N, 2008, LANCET, V371, P1927, DOI 10.1016/S0140-6736(08)60602-9
   Schauer PR, 2014, NEW ENGL J MED, V370, P2002, DOI 10.1056/NEJMoa1401329
   Schlueter N, 2014, PHARMACOL THERAPEUT, V144, P12, DOI 10.1016/j.pharmthera.2014.04.007
   Schwartz GG, 2012, NEW ENGL J MED, V367, P2089, DOI 10.1056/NEJMoa1206797
   Scirica BM, 2013, NEW ENGL J MED, V369, P1317, DOI 10.1056/NEJMoa1307684
   Seale P, 2009, GENE DEV, V23, P788, DOI 10.1101/gad.1779209
   Seijkens T, 2014, DIABETES, V63, P3982, DOI 10.2337/db14-0272
   Seshasai SRK, 2012, ARCH INTERN MED, V172, P209, DOI 10.1001/archinternmed.2011.628
   Shafi T, 2008, HYPERTENSION, V52, P1022, DOI 10.1161/HYPERTENSIONAHA.108.119438
   Sharma AM, 2001, HYPERTENSION, V37, P250, DOI 10.1161/01.HYP.37.2.250
   Sjöström L, 2004, NEW ENGL J MED, V351, P2683, DOI 10.1056/NEJMoa035622
   Sjöström L, 2007, NEW ENGL J MED, V357, P741, DOI 10.1056/NEJMoa066254
   Sookoian S, 2011, CURR HYPERTENS REP, V13, P149, DOI 10.1007/s11906-010-0164-9
   Spector R, 2011, PHARMACOLOGY, V87, P63, DOI 10.1159/000322999
   Stears AJ, 2012, HYPERTENSION, V59, P934, DOI 10.1161/HYPERTENSIONAHA.111.189381
   Strazzullo P, 2007, HYPERTENSION, V49, P792, DOI 10.1161/01.HYP.0000259737.43916.42
   Suez J, 2014, NATURE, V514, P181, DOI 10.1038/nature13793
   Taylor F, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004816.pub5
   Terán-García M, 2007, APPL PHYSIOL NUTR ME, V32, P89, DOI 10.1139/h06-102
   Thoms G, 1966, Dtsch Med J, V17, P70
   Tonelli M, 2011, CAN MED ASSOC J, V183, pE1189, DOI 10.1503/cmaj.101280
   Tonkin AM, 2010, CIRCULATION, V122, P850, DOI 10.1161/CIRCULATIONAHA.110.960112
   Torgerson JS, 2004, DIABETES CARE, V27, P155, DOI 10.2337/diacare.27.1.155
   Tuomilehto Jaakko, 2001, New England Journal of Medicine, V344, P1343, DOI 10.1056/NEJM200105033441801
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Ullah MI, 2011, HORM METAB RES, V43, P153, DOI 10.1055/s-0030-1270521
   VAGUE J, 1956, AM J CLIN NUTR, V4, P20, DOI 10.1093/ajcn/4.1.20
   Van Gaal LF, 2006, NATURE, V444, P875, DOI 10.1038/nature05487
   Verdecchia P, 2005, HYPERTENSION, V46, P386, DOI 10.1161/01.HYP.0000174591.42889.a2
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wallentin L, 2009, NEW ENGL J MED, V361, P1045, DOI 10.1056/NEJMoa0904327
   White WB, 2013, NEW ENGL J MED, V369, P1327, DOI 10.1056/NEJMoa1305889
   Wright JT, 2015, NEW ENGL J MED, V373, P2103, DOI 10.1056/NEJMoa1511939
   Wynne K, 2006, INT J OBESITY, V30, P1729, DOI 10.1038/sj.ijo.0803344
   Wynne K, 2005, DIABETES, V54, P2390, DOI 10.2337/diabetes.54.8.2390
   Yagi S, 2010, J ATHEROSCLER THROMB, V17, P173, DOI 10.5551/jat.2378
   Yusuf S, 2000, NEW ENGL J MED, V342, P145
   Yusuf S, 2008, NEW ENGL J MED, V358, P1547, DOI 10.1056/NEJMoa0801317
   Yusuf S, 2011, LANCET, V378, P1231, DOI 10.1016/S0140-6736(11)61215-4
   Zinman B, 2015, NEW ENGL J MED, V373, P2117, DOI 10.1056/NEJMoa1504720
   Zinman B, 2010, LANCET, V376, P103, DOI 10.1016/S0140-6736(10)60746-5
NR 151
TC 30
Z9 31
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1389-9155
EI 1573-2606
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD MAR
PY 2016
VL 17
IS 1
BP 5
EP 17
DI 10.1007/s11154-016-9345-4
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DN2IR
UT WOS:000376887800002
PM 26956847
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Caimi, G
   Hopps, E
   Montana, M
   Carollo, C
   Calandrino, V
   Gallà, E
   Canino, B
   Lo Presti, R
AF Caimi, Gregorio
   Hopps, Eugenia
   Montana, Maria
   Carollo, Caterina
   Calandrino, Vincenzo
   Galla, Eleonora
   Canino, Baldassare
   Lo Presti, Rosalia
TI Behaviour of carbonyl groups in several clinical conditions: Analysis of
   our survey
SO CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
LA English
DT Article
DE Oxidative stress; arterial hypertension; metabolic syndrome; juvenile
   myocardial infarction; chronic kidney failure
ID OXIDATION PROTEIN PRODUCTS; OBSTRUCTIVE SLEEP-APNEA; TOTAL ANTIOXIDANT
   STATUS; LIPID-PEROXIDATION; METABOLIC SYNDROME; END-PRODUCTS;
   CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; STRESS BIOMARKERS;
   PHYSICAL-ACTIVITY
AB Protein carbonylation is a marker of oxidative protein damage, that is likely involved in the pathogenesis of several diseases. The aim of this study was to evaluate the protein carbonyl (PC) groups in different clinical conditions. It included different groups of subjects: 81 trained subjects; 23 subjects with mild essential hypertension; 31 middle-aged subjects with metabolic syndrome (MS); 106 subjects with MS not selected for age (subdivided into two subgroups, with and without diabetes mellitus); 91 obese adults subdivided in two subgroups (BMI 30-35 Kg/m(2) and BMI > 35 kg/m(2)); 48 subjects with obstructive sleep apnea syndrome (OSAS) subdivided in accordance with the apnea/hypopnea index (AHI); 27 subjects with chronic kidney disease (CKD) on conservative therapy; 31 subjects with CKD on haemodialysis treatment; and 50 subjects with juvenile myocardial infarction. PC groups were reduced in trained subjects in comparison with sedentary controls, while no variation was observed in mild essential hypertension. PC groups were increased in MS subjects and in adult obese subjects. In MS subjects the PC groups were not influenced by the presence of diabetes mellitus and in adult obese subjects were not influenced by the obesity degree. In OSAS subjects only those with AHI > 30 showed an increase of PC groups. PC groups increased in CKD subjects undergoing conservative treatment and haemodialysis therapy. In dialyzed subjects, after a standard dialysis session, there was a marked increase in PC groups. In juvenile myocardial infarction PC groups were higher than in controls; there was no difference between STEMI and NSTEMI and their concentration was unaffected by the number of cardiovascular risk factors or stenosed coronary vessels.
C1 [Caimi, Gregorio; Hopps, Eugenia; Montana, Maria; Carollo, Caterina; Calandrino, Vincenzo; Galla, Eleonora; Canino, Baldassare] Univ Palermo, Dept Hlth Promot Mother & Child Care, Internal Med & Med Specialties, Via Vespro 129, I-90100 Palermo, Italy.
   [Lo Presti, Rosalia] Univ Palermo, Dept Psychol Educ Sci & Human Movement, Palermo, Italy.
C3 University of Palermo; University of Palermo
RP Caimi, G (corresponding author), Univ Palermo, Dept Hlth Promot Mother & Child Care, Internal Med & Med Specialties, Via Vespro 129, I-90100 Palermo, Italy.
EM gregorio.caimi@unipa.it
RI Carollo, Caterina/AAT-3063-2021; Montaña, Fernanda/ADG-6031-2022;
   Presti, Rosalia/J-5394-2016
OI CAROLLO, Caterina/0000-0002-6767-8823
CR Alessio HM, 2000, MED SCI SPORT EXER, V32, P1576
   Amirkhizi F, 2007, ARYA ATHEROSCLER, V2, P189
   Andrulli S, 2010, NEPHRON CLIN PRACT, V115, pE82, DOI 10.1159/000294281
   Aveles PR, 2010, NEPHRON CLIN PRACT, V116, pC294, DOI 10.1159/000318792
   Bagatini MD, 2011, HEART VESSELS, V26, P55, DOI 10.1007/s00380-010-0029-9
   Balakrishnan SD, 1998, CELL BIOCHEM FUNCT, V16, P269, DOI 10.1002/(SICI)1099-0844(1998120)16:4<269::AID-CBF797>3.3.CO;2-2
   Bargnoux AS, 2013, J NEPHROL, V26, P556, DOI 10.5301/jn.5000195
   Barsotti A, 2011, CLIN BIOCHEM, V44, P605, DOI 10.1016/j.clinbiochem.2011.03.134
   Berzosa C, 2011, EUR J APPL PHYSIOL, V111, P1127, DOI 10.1007/s00421-010-1738-6
   Bloomer RJ, 2008, GENDER MED, V5, P218, DOI 10.1016/j.genm.2008.07.002
   Bollineni RC, 2014, J PROTEOME RES, V13, P5081, DOI 10.1021/pr500324y
   Bordoni V, 2006, BLOOD PURIFICAT, V24, P149, DOI 10.1159/000089452
   Boulanger E, 2006, PERITON DIALYSIS INT, V26, P207
   Caimi G, 2012, CLIN HEMORHEOL MICRO, V50, P193, DOI 10.3233/CH-2011-1423
   Caimi G, 2010, CLIN HEMORHEOL MICRO, V46, P321, DOI 10.3233/CH-2010-1360
   Caimi G, 2019, HORM METAB RES, V51, P389, DOI 10.1055/a-0887-2770
   Caimi G, 2013, CLIN HEMORHEOL MICRO, V54, P409, DOI 10.3233/CH-131739
   Caimi G, 2013, CLIN HEMORHEOL MICRO, V53, P297, DOI 10.3233/CH-2012-1551
   Caimi G, 2013, DIABETES METAB SYND, V7, P38, DOI 10.1016/j.dsx.2013.02.013
   Caimi G, 2009, CLIN HEMORHEOL MICRO, V43, P233, DOI 10.3233/CH-2009-1215
   Caner M, 2006, INT J CLIN PRACT, V60, P1565, DOI 10.1111/j.1742-1241.2006.00959.x
   Catoi AF, 2013, OBES SURG, V23, P1858, DOI 10.1007/s11695-013-0968-1
   Chen KK, 2011, FREE RADICAL RES, V45, P568, DOI 10.3109/10715762.2011.557723
   Chouchani ET, 2011, CURR OPIN CHEM BIOL, V15, P120, DOI 10.1016/j.cbpa.2010.11.003
   Codoñer-Franch P, 2010, ACTA PAEDIATR, V99, P1841, DOI 10.1111/j.1651-2227.2010.01903.x
   D'Archivio M, 2012, EUR J CLIN INVEST, V42, P70, DOI 10.1111/j.1365-2362.2011.02558.x
   Dalle-Donne I, 2006, CLIN CHEM, V52, P601, DOI 10.1373/clinchem.2005.061408
   Dalle-Donne I, 2006, J CELL MOL MED, V10, P389, DOI 10.1111/j.1582-4934.2006.tb00407.x
   Drozdz D, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/7520231
   Dursun E, 2005, ANN CLIN BIOCHEM, V42, P64, DOI 10.1258/0004563053026808
   Falone S, 2010, PHYSIOL RES, V59, P953, DOI 10.33549/physiolres.931884
   Feng Y, 2010, HEART VESSELS, V25, P374, DOI 10.1007/s00380-009-1220-8
   Frijhoff J, 2015, ANTIOXID REDOX SIGN, V23, P1144, DOI 10.1089/ars.2015.6317
   Frohnert BI, 2011, OBESITY, V19, P1735, DOI 10.1038/oby.2011.115
   Galvani S, 2008, FREE RADICAL BIO MED, V45, P1457, DOI 10.1016/j.freeradbiomed.2008.08.026
   Gaxioa-Robles R, 2013, NUTR HOSP, V28, P1905, DOI [10.3305/nh.2013.28.6.6946, 10.3305/nutr hosp.v28in06.6946]
   Giustarini D, 2004, J CELL MOL MED, V8, P201, DOI 10.1111/j.1582-4934.2004.tb00275.x
   Guo ZJ, 2008, ANTIOXID REDOX SIGN, V10, P1699, DOI 10.1089/ars.2007.1999
   Hecker M, 2018, J INHERIT METAB DIS, V41, P29, DOI 10.1007/s10545-017-0104-9
   Hopps E, 2014, EUR REV MED PHARMACO, V18, P3773
   Hopps E, 2013, NUTR METAB CARDIOVAS, V23, pE17, DOI 10.1016/j.numecd.2013.01.010
   Hopps E, 2010, NUTR METAB CARDIOVAS, V20, P72, DOI 10.1016/j.numecd.2009.06.002
   Hopps E, 2013, CLIN INVEST MED, V36, pE1
   Kalousová M, 2002, PHYSIOL RES, V51, P597, DOI 10.33549/physiolres.930234
   Kalousová M, 2005, MUTAT RES-FUND MOL M, V579, P37, DOI 10.1016/j.mrfmmm.2005.03.024
   Kedziora-Kornatowska K, 2004, CELL MOL BIOL LETT, V9, P635
   Kent BD, 2011, RESP PHYSIOL NEUROBI, V178, P475, DOI 10.1016/j.resp.2011.03.015
   Köken T, 2004, NEPHROLOGY, V9, P77, DOI 10.1111/j.1440-1797.2004.00240.x
   Krzystek-Korpacka M, 2008, CLIN BIOCHEM, V41, P943, DOI 10.1016/j.clinbiochem.2008.04.024
   Lavie L, 2009, EUR RESPIR J, V33, P1467, DOI 10.1183/09031936.00086608
   Li GL, 2010, REDOX REP, V15, P268, DOI 10.1179/135100010X12826446921743
   Li GL, 2010, CLIN HEMORHEOL MICRO, V46, P305, DOI 10.3233/CH-2010-1355
   Li Zhong-hai, 2006, Nan Fang Yi Ke Da Xue Xue Bao, V26, P558
   Li Zi, 2006, Sichuan Da Xue Xue Bao Yi Xue Ban, V37, P123
   Lira AB, 2016, SLEEP BREATH, V20, P1155, DOI 10.1007/s11325-016-1367-3
   Liu SX, 2006, ARTERIOSCL THROM VAS, V26, P1156, DOI 10.1161/01.ATV.0000214960.85469.68
   Lo Presti R, 2012, CLIN HEMORHEOL MICRO, V51, P111, DOI 10.3233/CH-2011-1518
   Lo Presti R, 2008, CLIN HEMORHEOL MICRO, V38, P93
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   Lynch BM, 2011, RECENT RESULTS CANC, V186, P13, DOI 10.1007/978-3-642-04231-7_2
   Mancuso M, 2012, SLEEP MED, V13, P632, DOI 10.1016/j.sleep.2011.10.030
   Marin JM, 2005, LANCET, V365, P1046, DOI 10.1016/S0140-6736(05)71141-7
   Marzatico F, 1997, J SPORT MED PHYS FIT, V37, P235
   Matsuyama Y, 2009, CLIN EXP NEPHROL, V13, P308, DOI 10.1007/s10157-009-0161-y
   Meaney E, 2008, CLIN EXP PHARMACOL P, V35, P895, DOI 10.1111/j.1440-1681.2008.04920.x
   Michailidis Y, 2007, MED SCI SPORT EXER, V39, P1107, DOI 10.1249/01.mss.0b013e318053e7ba
   Nandeesha H, 2007, Indian J Med Sci, V61, P326
   Negre-Salvayre A, 2008, BRIT J PHARMACOL, V153, P6, DOI 10.1038/sj.bjp.0707395
   Oberg BP, 2004, KIDNEY INT, V65, P1009, DOI 10.1111/j.1523-1755.2004.00465.x
   Pandey KB, 2010, OXID MED CELL LONGEV, V3, P2, DOI 10.4161/oxim.3.1.10476
   Papandreou C, 2013, SLEEP BREATH, V17, P1319, DOI 10.1007/s11325-013-0819-2
   Punjabi NM, 2009, PLOS MED, V6, DOI 10.1371/journal.pmed.1000132
   Pupim LB, 2004, KIDNEY INT, V65, P2371, DOI 10.1111/j.1523-1755.2004.00656.x
   Radak Z, 2010, J ALZHEIMERS DIS, V20, P777, DOI 10.3233/JAD-2010-091531
   Rutkowski P, 2006, J RENAL NUTR, V16, P190, DOI 10.1053/j.jrn.2006.04.008
   Sebeková K, 2006, MOL NUTR FOOD RES, V50, P858, DOI 10.1002/mnfr.200500170
   Sentürk ÜK, 2005, J APPL PHYSIOL, V99, P1434, DOI 10.1152/japplphysiol.01392.2004
   Serdar Z, 2007, ACTA CARDIOL, V62, P373, DOI 10.2143/AC.62.4.2022281
   Simic DV, 2006, J HUM HYPERTENS, V20, P149, DOI 10.1038/sj.jhh.1001945
   Skvarilova Marcela, 2005, Biomedical Papers (Olomouc), V149, P83
   Sledzinski T, 2009, OBES SURG, V19, P321, DOI 10.1007/s11695-008-9691-8
   Sofi F, 2008, EUR J CARDIOV PREV R, V15, P247, DOI 10.1097/HJR.0b013e3282f232ac
   Stadtman ER, 2001, ANN NY ACAD SCI, V928, P22
   Stefanovic A, 2008, DIABETES RES CLIN PR, V79, P156, DOI 10.1016/j.diabres.2007.07.019
   Tinahones FJ, 2009, OBESITY, V17, P240, DOI 10.1038/oby.2008.536
   Tripathi P, 2009, INDIAN J BIOCHEM BIO, V46, P498
   Tripathi P, 2009, OXID MED CELL LONGEV, V2, P231, DOI 10.4161/oxim.2.4.9233
   Uzun H, 2007, OBES SURG, V17, P1367, DOI 10.1007/s11695-007-9242-8
   Vatansever E, 2011, SLEEP BREATH, V15, P275, DOI 10.1007/s11325-010-0378-8
   Venturini D, 2012, OBESITY, V20, P2361, DOI 10.1038/oby.2012.130
   Vidart J, 2014, J CLIN ENDOCR METAB, V99, P4537, DOI 10.1210/jc.2014-2192
   Wang X, 2013, INT J CARDIOL, V169, P207, DOI 10.1016/j.ijcard.2013.08.088
   Witko-Sarsat W, 2003, KIDNEY INT, V64, P82, DOI 10.1046/j.1523-1755.2003.00044.x
   Yaggi HK, 2005, NEW ENGL J MED, V353, P2034, DOI 10.1056/NEJMoa043104
   Yildirim E, 2017, ANATOL J CARDIOL, V17, P210, DOI 10.14744/AnatolJCardiol.2016.7174
   Yuan Fang, 2004, Di Yi Jun Yi Da Xue Xue Bao, V24, P1350
NR 96
TC 5
Z9 6
U1 0
U2 2
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1386-0291
EI 1875-8622
J9 CLIN HEMORHEOL MICRO
JI Clin. Hemorheol. Microcirc.
PY 2020
VL 74
IS 3
BP 299
EP 313
DI 10.3233/CH-190689
PG 15
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA OR2EC
UT WOS:000589286900008
PM 31683469
OA Green Published
DA 2025-06-11
ER

PT J
AU Godala, MM
   Materek-Kusmierkiewicz, I
   Moczulski, D
   Rutkowski, M
   Szatko, F
   Gaszynska, E
   Tokarski, S
   Kowalski, J
AF Godala, Malgorzata M.
   Materek-Kusmierkiewicz, Izabela
   Moczulski, Dariusz
   Rutkowski, Maciej
   Szatko, Franciszek
   Gaszynska, Ewelina
   Tokarski, Slawomir
   Kowalski, Jan
TI Lower Plasma Levels of Antioxidant Vitamins in Patients with Metabolic
   Syndrome: A Case Control Study
SO ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE metabolic syndrome; diet; oxidative stress; antioxidant vitamins
ID SERUM ALPHA-TOCOPHEROL; OXIDATIVE STRESS; BETA-CAROTENE;
   ALCOHOL-CONSUMPTION; RISK; DIET; DETERMINANTS; PREVALENCE; DISEASE;
   SMOKING
AB Background. Metabolic syndrome (MS) is a coexistence of metabolic risk factors affecting the development of cardiovascular diseases. Reactive oxygen species, which are excessively produced in MS, participate in its pathogenesis. Vitamins A, C and E are an important part of the non-enzymatic antioxidative barrier in humans.
   Objectives. The aim of the study was to estimate plasma vitamin A, C and E levels and the intake of these vitamins from the diet in patients with MS.
   Material and Methods. The study included 182 patients with MS, 94 men and 88 women, aged 30-65 years (mean 57.31 +/- 8.28 years). The control group was comprised of 91 subjects, 56 men and 35 women, aged 41-65 years (mean 57.75 +/- 5.84 years). The MS diagnosis was based on IDF criteria. The determination of the serum level of vitamin A, C and E was performed using the spectrophotometric method. The food intake was assessed by 24-h dietary recall.
   Results. The mean plasma vitamin A, C and E levels were significantly lower in MS patients than in the controls (p = 0.05). No correlation was found between vitamin A, C and E intake from the diet and their plasma concentrations in MS patients. Plasma vitamin A, C and E deficiency was observed significantly more often in MS patients than in the control group (15.38% vs. 2.19%, 79.12% vs. 8.79% and 60.45% vs. 5.49%, p < 0.0001, respectively). BMI was the one factor significantly affecting the mean value of vitamin A, C and E levels in MS patients.
   Conclusions. MS patients demonstrated significantly lower plasma levels of vitamin A, C and E compared to the healthy subjects. Lower plasma levels of antioxidant vitamins with their high intake from the diet indicate antioxidant barrier impairment in MS patients
C1 [Godala, Malgorzata M.] Med Univ Lodz, Chair Hyg & Epidemiol, Dept Nutr & Epidemiol, Lodz, Poland.
   [Materek-Kusmierkiewicz, Izabela; Moczulski, Dariusz] Med Univ Lodz, Chair Internal Dis & Cardiol, Dept Internal Med & Nephrodiabetol, Lodz, Poland.
   [Rutkowski, Maciej] Med Univ Lodz, Dept Mil Toxicol & Radiol Protect, Lodz, Poland.
   [Szatko, Franciszek; Gaszynska, Ewelina] Med Univ Lodz, Chair Hyg & Epidemiol, Dept Hyg & Hlth Promot, Lodz, Poland.
   [Tokarski, Slawomir] Univ Rzeszow, Fac Med, Rzeszow, Poland.
   [Kowalski, Jan] Med Univ Lodz, Dept Internal & Infect Dis, Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz; Medical University
   Lodz; Medical University Lodz; University of Rzeszow; Medical University
   Lodz
RP Godala, MM (corresponding author), Med Univ Lodz, Dept Nutr & Epidemiol, Ul Romanowska 55H-6, PL-91174 Lodz, Poland.
EM malgorzata.godala@umed.lodz.pl
RI Rutkowski, Maciej/S-9910-2016; Kowalski, Jan/HDM-3504-2022; Gaszynska,
   Ewelina/S-9946-2016; Godala, Malgorzata/S-9597-2016
OI Tokarski, Slawomir/0000-0003-1153-0667; Gaszynska,
   Ewelina/0000-0001-7568-3502; Materek-Kusmierkiewicz,
   Izabela/0000-0001-5912-4516; Moczulski, Dariusz/0000-0002-0926-9909;
   Godala, Malgorzata/0000-0003-3579-8537
FU Medical University in Lodz [502-03/6-024-02/502-64-050]
FX The study was financed by the Medical University in Lodz (research task
   No: 502-03/6-024-02/502-64-050).
CR Al-Daghri NM, 2013, NUTRIENTS, V5, P4587, DOI 10.3390/nu5114587
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   [Anonymous], STANDARDS HUMAN NUTR, DOI DOI 10.1007/s11883-016-0575-4
   [Anonymous], 2 FACE OXYGEN
   Beydoun MA, 2011, J NUTR, V141, P903, DOI 10.3945/jn.110.136580
   Cahill L, 2009, AM J EPIDEMIOL, V170, P464, DOI 10.1093/aje/kwp156
   Czernichow S, 2009, AM J CLIN NUTR, V90, P329, DOI 10.3945/ajcn.2009.27635
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Ford ES, 2005, DIABETES CARE, V28, P2745, DOI 10.2337/diacare.28.11.2745
   Fujita K, 2006, CIRC J, V70, P1437, DOI 10.1253/circj.70.1437
   Galan P, 2005, EUR J CLIN NUTR, V59, P1181, DOI 10.1038/sj.ejcn.1602230
   Garcia-Bailo B, 2011, BIOL-TARGETS THER, V5, P7, DOI 10.2147/BTT.S14417
   GasconVila P, 1997, EUR J CLIN NUTR, V51, P723, DOI 10.1038/sj.ejcn.1600472
   Grundy SM, 2004, J CLIN ENDOCR METAB, V89, P2750
   HEBERT JR, 1994, AM J EPIDEMIOL, V140, P132, DOI 10.1093/oxfordjournals.aje.a117224
   HUBERT HB, 1983, CIRCULATION, V67, P968, DOI 10.1161/01.CIR.67.5.968
   Illison VK, 2011, INT J VITAM NUTR RES, V81, P12, DOI 10.1024/0300-9831/a000046
   Kim KN, 2006, J NUTR BIOCHEM, V17, P454, DOI 10.1016/j.jnutbio.2005.10.009
   KNEKT P, 1988, PREV MED, V17, P725, DOI 10.1016/0091-7435(88)90091-6
   Kowalski J, 2007, METABOLIC SYNDROME P, P173
   Kowalski Jan, 2011, Pol Merkur Lekarski, V30, P249
   Kowalski Jan, 2011, Pol Merkur Lekarski, V30, P241
   Kunachowicz H., 2005, CHARTS NUTR VALUES P
   KUZUYA M, 1991, J LIPID RES, V32, P197
   Lamb RE, 2008, INT J CLIN PRACT, V62, P1087, DOI 10.1111/j.1742-1241.2008.01789.x
   Liu C, 2004, J NUTR, V134, P426, DOI 10.1093/jn/134.2.426
   Losonczy KG, 1996, AM J CLIN NUTR, V64, P190, DOI 10.1093/ajcn/64.2.190
   Neuhouser ML, 2001, J NUTR, V131, P2184, DOI 10.1093/jn/131.8.2184
   Odum E P, 2012, Niger Postgrad Med J, V19, P199
   OHRVALL M, 1993, J INTERN MED, V234, P53
   RIEMERSMA RA, 1991, LANCET, V337, P1, DOI 10.1016/0140-6736(91)93327-6
   Roberts CK, 2006, METABOLISM, V55, P928, DOI 10.1016/j.metabol.2006.02.022
   Rock CL, 1999, J NUTR, V129, P855, DOI 10.1093/jn/129.4.855
   Rutkowski M, 2004, Z NATURFORSCH C, V59, P762
   Rutkowski M., 1998, DIAGN LAB, V34, P511
   Rutkowski M., 2006, Journal of Physiology and Pharmacology, V57, P221
   Rutkowski M., 2005, DIAGN LAB, V41, P375
   Sharma P, 2005, INDIAN J CLIN BIOCHE, V20, P145, DOI 10.1007/BF02893061
   SINGH RB, 1995, AM J CARDIOL, V76, P1233, DOI 10.1016/S0002-9149(99)80348-8
   SINHA R, 1993, CANCER EPIDEM BIOMAR, V2, P473
   Sluijs I, 2009, J NUTR, V139, P987, DOI 10.3945/jn.108.101451
   Sohn C, 2012, NUTR RES PRACT, V6, P246, DOI 10.4162/nrp.2012.6.3.246
   Szponar L., 2000, Album of Photographs of Food Products and Dishes
   Tokarski Slawomir, 2013, Pol Merkur Lekarski, V35, P136
   Wallström P, 2001, AM J CLIN NUTR, V73, P777
   White E, 2001, ANN EPIDEMIOL, V11, P136, DOI 10.1016/S1047-2797(00)00189-7
   Zdrojewski T., 2004, Kardiol Pol, V61, P5
NR 47
TC 29
Z9 29
U1 0
U2 3
PU WROCLAW MEDICAL UNIV
PI WROCLAW
PA UL K MARCINKOWSKIEGO 2-6, WROCLAW, 50-368, POLAND
SN 1899-5276
EI 2451-2680
J9 ADV CLIN EXP MED
JI Adv. Clin. Exp. Med.
PD JUL-AUG
PY 2016
VL 25
IS 4
BP 689
EP 700
DI 10.17219/acem/41049
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DY0XX
UT WOS:000384820600012
PM 27629843
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Kolodkin, A
   Sahin, N
   Phillips, A
   Hood, SR
   Bruggeman, FJ
   Westerhoff, HV
   Plant, N
AF Kolodkin, Alexey
   Sahin, Nilgun
   Phillips, Anna
   Hood, Steve R.
   Bruggeman, Frank J.
   Westerhoff, Hans V.
   Plant, Nick
TI Optimization of stress response through the nuclear receptor-mediated
   cortisol signalling network
SO NATURE COMMUNICATIONS
LA English
DT Article
ID PREGNANE-X RECEPTOR; GLUCOCORTICOID-RECEPTOR; TRANSCRIPTIONAL
   REGULATION; METABOLIC SYNDROME; DOWN-REGULATION; CYP3A4; GENE; ALPHA;
   PXR; IDENTIFICATION
AB It is an accepted paradigm that extended stress predisposes an individual to pathophysiology. However, the biological adaptations to minimize this risk are poorly understood. Using a computational model based upon realistic kinetic parameters we are able to reproduce the interaction of the stress hormone cortisol with its two nuclear receptors, the high-affinity glucocorticoid receptor and the low-affinity pregnane X-receptor. We demonstrate that regulatory signals between these two nuclear receptors are necessary to optimize the body's response to stress episodes, attenuating both the magnitude and duration of the biological response. In addition, we predict that the activation of pregnane X-receptor by multiple, lowaffinity endobiotic ligands is necessary for the significant pregnane X-receptor-mediated transcriptional response observed following stress episodes. This integration allows responses mediated through both the high and low-affinity nuclear receptors, which we predict is an important strategy to minimize the risk of disease from chronic stress.
C1 [Kolodkin, Alexey] Univ Luxembourg, Luxembourg Ctr Syst Biomed, L-4362 Esch Sur Alzette, Luxembourg.
   [Sahin, Nilgun; Bruggeman, Frank J.; Westerhoff, Hans V.] Vrije Univ Amsterdam, Netherlands Inst Syst Biol, NL-1081 HV Amsterdam, Netherlands.
   [Phillips, Anna; Plant, Nick] Univ Surrey, Fac Hlth & Med Sci, Ctr Toxicol, Guildford GU2 7XH, Surrey, England.
   [Hood, Steve R.] GlaxoSmithKline, GOLD, Ware SG12 0DP, Herts, England.
   [Bruggeman, Frank J.] Netherlands Inst Syst Biol, Regulatory Networks Grp, NL-1081 HV Amsterdam, Netherlands.
   [Bruggeman, Frank J.] CWI, Ctr Math & Comp Sci, NL-1098 XG Amsterdam, Netherlands.
   [Westerhoff, Hans V.] Univ Manchester, Manchester Ctr Integrat Syst Biol, Manchester Interdisciplinary Bioctr, Manchester M1 7DN, Lancs, England.
   [Westerhoff, Hans V.] Univ Amsterdam, Swammerdam Inst Life Sci, Netherlands Inst Syst Biol, NL-1098 XH Amsterdam, Netherlands.
C3 University of Luxembourg; Vrije Universiteit Amsterdam; University of
   Surrey; GlaxoSmithKline; Glaxosmithkline United Kingdom; Centrum
   Wiskunde & Informatica (CWI); University of Manchester; University of
   Amsterdam
RP Plant, N (corresponding author), Univ Surrey, Fac Hlth & Med Sci, Ctr Toxicol, Guildford GU2 7XH, Surrey, England.
EM N.Plant@Surrey.ac.uk
RI Whittaker, Anna/A-3577-2013; Bruggeman, Frank/AAS-8371-2020; Plant,
   Nick/E-4510-2011; Kolodkin, Alexey/AFL-8732-2022; Bruggeman,
   Frank/C-4356-2015; Westerhoff, Hans/I-5762-2012
OI Plant, Nick/0000-0003-4332-8308; Kolodkin, Alexey/0000-0002-7466-5027;
   Bruggeman, Frank/0000-0002-0255-4766; Westerhoff,
   Hans/0000-0002-0443-6114
FU European Commission [MRTN-CT-2005-019496]; Nederlandse organisatie voor
   internationalisering in het hoger onderwijs (NUFFIC); Biotechnology and
   Biosciences Research Council UK (BBSRC); GlaxoSmithKline
FX This work was supported by the European Commission
   (MRTN-CT-2005-019496), Nederlandse organisatie voor internationalisering
   in het hoger onderwijs (NUFFIC), Biotechnology and Biosciences Research
   Council UK (BBSRC) and GlaxoSmithKline.
CR Anagnostis P, 2009, J CLIN ENDOCR METAB, V94, P2692, DOI 10.1210/jc.2009-0370
   Aouabdi S, 2006, DRUG METAB DISPOS, V34, P138, DOI 10.1124/dmd.105.006064
   Arda HE, 2010, MOL SYST BIOL, V6, DOI 10.1038/msb.2010.23
   Bailey I, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016703
   Bertilsson G, 1998, P NATL ACAD SCI USA, V95, P12208, DOI 10.1073/pnas.95.21.12208
   Blumberg B, 1998, GENE DEV, V12, P3195, DOI 10.1101/gad.12.20.3195
   Bombail V, 2004, DRUG METAB DISPOS, V32, P525, DOI 10.1124/dmd.32.5.525
   Conrad CD, 2010, PROG NEURO-PSYCHOPH, V34, P742, DOI 10.1016/j.pnpbp.2009.11.003
   Conrad CD, 2008, REV NEUROSCIENCE, V19, P395
   El-Sankary W, 2000, DRUG METAB DISPOS, V28, P493
   El-Sankary W, 2002, DRUG METAB DISPOS, V30, P1029, DOI 10.1124/dmd.30.9.1029
   El-Sankary W, 2001, DRUG METAB DISPOS, V29, P1499
   Fabre B, 2013, STRESS, V16, P16, DOI 10.3109/10253890.2012.676112
   Francis GA, 2003, ANNU REV PHYSIOL, V65, P261, DOI 10.1146/annurev.physiol.65.092101.142528
   Gibson GG, 2006, DRUG METAB REV, V38, P31, DOI 10.1080/03602530600569810
   Golier JA, 2007, BIOL PSYCHIAT, V62, P1175, DOI 10.1016/j.biopsych.2007.04.027
   Goligorsky MS, 2001, AM J PHYSIOL-RENAL, V280, pF551, DOI 10.1152/ajprenal.2001.280.4.F551
   Handschin C, 2005, ARCH BIOCHEM BIOPHYS, V433, P387, DOI 10.1016/j.abb.2004.08.030
   Handschin Christoph, 2004, Nucl Recept, V2, P7, DOI 10.1186/1478-1336-2-7
   Hartley TA, 2012, J ENVIRON PUBLIC HEA, V2012, DOI 10.1155/2012/861219
   Hoops S, 2006, BIOINFORMATICS, V22, P3067, DOI 10.1093/bioinformatics/btl485
   Huizenga NATM, 2000, EUR J ENDOCRINOL, V142, P472, DOI 10.1530/eje.0.1420472
   KIRSCHBAUM C, 1995, PSYCHOSOM MED, V57, P468, DOI 10.1097/00006842-199509000-00009
   Kitano H, 2004, NAT REV GENET, V5, P826, DOI 10.1038/nrg1471
   Kliewer SA, 1998, CELL, V92, P73, DOI 10.1016/S0092-8674(00)80900-9
   Koefoed S, 2002, BBA-BIOENERGETICS, V1555, P75, DOI 10.1016/S0005-2728(02)00258-X
   Kolodkin AN, 2010, MOL SYST BIOL, V6, DOI 10.1038/msb.2010.102
   Madan A, 2003, DRUG METAB DISPOS, V31, P421, DOI 10.1124/dmd.31.4.421
   Masson MJ, 2010, BIOCHEM BIOPH RES CO, V397, P453, DOI 10.1016/j.bbrc.2010.05.126
   MUNCK A, 1984, ENDOCR REV, V5, P25, DOI 10.1210/edrv-5-1-25
   Oakley Robert H., 1993, Critical Reviews in Eukaryotic Gene Expression, V3, P63
   Pan D, 2011, CANCER RES, V71, P6360, DOI 10.1158/0008-5472.CAN-11-0362
   Pascussi JM, 2000, MOL PHARMACOL, V58, P361, DOI 10.1124/mol.58.2.361
   Plant N, 2009, XENOBIOTICA, V39, P597, DOI 10.1080/00498250903098218
   Plant N, 2007, BBA-GEN SUBJECTS, V1770, P478, DOI 10.1016/j.bbagen.2006.09.024
   Polman JAE, 2012, BMC NEUROSCI, V13, DOI 10.1186/1471-2202-13-118
   RIGAUD G, 1991, CELL, V67, P977, DOI 10.1016/0092-8674(91)90370-E
   Sher L, 2004, MED HYPOTHESES, V62, P198, DOI 10.1016/S0306-9877(03)00320-7
   Shively CA, 2009, AM J PRIMATOL, V71, P742, DOI 10.1002/ajp.20706
   Wada T, 2009, TRENDS ENDOCRIN MET, V20, P273, DOI 10.1016/j.tem.2009.03.003
NR 40
TC 22
Z9 24
U1 0
U2 15
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD APR
PY 2013
VL 4
AR 1792
DI 10.1038/ncomms2799
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 143MR
UT WOS:000318872100149
PM 23653204
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Khalil, M
   Shanmugam, H
   Abdallah, H
   Britto, JSJ
   Galerati, I
   Gómez-Ambrosi, J
   Frühbeck, G
   Portincasa, P
AF Khalil, Mohamad
   Shanmugam, Harshitha
   Abdallah, Hala
   Britto, Jerlin Stephy John
   Galerati, Ilaria
   Gomez-Ambrosi, Javier
   Fruhbeck, Gema
   Portincasa, Piero
TI The Potential of the Mediterranean Diet to Improve Mitochondrial
   Function in Experimental Models of Obesity and Metabolic Syndrome
SO NUTRIENTS
LA English
DT Review
DE obesity; mitochondria; Mediterranean diet; metabolic syndrome;
   plant-based foods; polyphenols; polyunsaturated fatty acids
ID FATTY LIVER-DISEASE; CORONARY-HEART-DISEASE; BODY-MASS INDEX; ACTIVATED
   PROTEIN-KINASE; ENERGY SENSING NETWORK; HUMAN SKELETAL-MUSCLE;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; ADIPOSE-TISSUE; SARCOPENIC
   OBESITY
AB The abnormal expansion of body fat paves the way for several metabolic abnormalities including overweight, obesity, and diabetes, which ultimately cluster under the umbrella of metabolic syndrome (MetS). Patients with MetS are at an increased risk of cardiovascular disease, morbidity, and mortality. The coexistence of distinct metabolic abnormalities is associated with the release of pro-inflammatory adipocytokines, as components of low-to-medium grade systemic inflammation and increased oxidative stress. Adopting healthy lifestyles, by using appropriate dietary regimens, contributes to the prevention and treatment of MetS. Metabolic abnormalities can influence the function and energetic capacity of mitochondria, as observed in many obesity-related cardio-metabolic disorders. There are preclinical studies both in cellular and animal models, as well as clinical studies, dealing with distinct nutrients of the Mediterranean diet (MD) and dysfunctional mitochondria in obesity and MetS. The term "Mitochondria nutrients" has been adopted in recent years, and it depicts the adequate nutrients to keep proper mitochondrial function. Different experimental models show that components of the MD, including polyphenols, plant-derived compounds, and polyunsaturated fatty acids, can improve mitochondrial metabolism, biogenesis, and antioxidant capacity. Such effects are valuable to counteract the mitochondrial dysfunction associated with obesity-related abnormalities and can represent the beneficial feature of polyphenols-enriched olive oil, vegetables, nuts, fish, and plant-based foods, as the main components of the MD. Thus, developing mitochondria-targeting nutrients and natural agents for MetS treatment and/or prevention is a logical strategy to decrease the burden of disease and medications at a later stage. In this comprehensive review, we discuss the effects of the MD and its bioactive components on improving mitochondrial structure and activity.
C1 [Khalil, Mohamad; Shanmugam, Harshitha; Abdallah, Hala; Britto, Jerlin Stephy John; Galerati, Ilaria; Portincasa, Piero] Univ Bari, Dept Biomed Sci & Human Oncol, Clin Med A Murri, Med Sch, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
   [Khalil, Mohamad] Univ Bari Aldo Moro, Dept Soil Plant & Food Sci, Via Amendola 165-A, I-70126 Bari, Italy.
   [Gomez-Ambrosi, Javier; Fruhbeck, Gema] Clin Univ Navarra, Metab Res Lab, Pamplona 31008, Spain.
   [Gomez-Ambrosi, Javier; Fruhbeck, Gema] ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Pamplona 28029, Spain.
   [Gomez-Ambrosi, Javier; Fruhbeck, Gema] Inst Invest Sanitaria Navarra IdiSNA, Obes & Adipobiol Grp, Pamplona 31008, Spain.
   [Fruhbeck, Gema] Clin Univ Navarra, Dept Endocrinol & Nutr, Pamplona 31008, Spain.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro; University of Navarra; Instituto de Salud Carlos III; CIBER -
   Centro de Investigacion Biomedica en Red; CIBEROBN; University of
   Navarra
RP Portincasa, P (corresponding author), Univ Bari, Dept Biomed Sci & Human Oncol, Clin Med A Murri, Med Sch, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
EM mohamad.khalil@uniba.it; harshitha.shanmugam@uniba.it;
   hala.abdallah@uniba.it; jerlin.johnbritto@uniba.it;
   ilariagalerati@live.it; jagomez@unay.es; gfruhbeck@unay.es;
   piero.portincasa@uniba.it
RI Shanmugam, Harshitha/LCE-0958-2024; Khalil, Mohamad/ISA-5550-2023;
   portincasa, piero/J-7245-2018; Gomez-Ambrosi, Javier/D-2984-2017
OI Fruhbeck, Gema/0000-0002-8305-7154; Gomez-Ambrosi,
   Javier/0000-0001-5601-1604; portincasa, piero/0000-0001-5359-1471
FU European Union's Horizon 2020 Research and Innovation program under the
   Marie Sklodowska-Curie Grant [722619, 734719]; Grant Regione Puglia [CUP
   H99C20000340002]; Grant EUROSEEDS Uniba-S56-By-Products Sustainable
   Recovery 4 Health (BSR-4H): University of Bari Aldo Moro, 2022
FX This paper has been partly supported by funding from the European
   Union's Horizon 2020 Research and Innovation program under the Marie
   Sklodowska-Curie Grant Agreement No. 722619 (FOIE GRAS), Grant Agreement
   No. 734719 (mtFOIE GRAS), Grant Regione Puglia, CUP H99C20000340002
   (Fever Apulia), and Grant EUROSEEDS Uniba-S56-By-Products Sustainable
   Recovery 4 Health (BSR-4H): University of Bari Aldo Moro, 2022.
CR ABATE N, 1995, J CLIN INVEST, V96, P88, DOI 10.1172/JCI118083
   Afshin A, 2017, NEW ENGL J MED, V377, P13, DOI 10.1056/NEJMoa1614362
   Ajaz S, 2021, MITOCHONDRION, V57, P119, DOI 10.1016/j.mito.2020.12.010
   Akil L, 2011, J HEALTH CARE POOR U, V22, P61, DOI 10.1353/hpu.2011.0166
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Alcázar-Fabra M, 2016, BBA-BIOENERGETICS, V1857, P1073, DOI 10.1016/j.bbabio.2016.03.010
   Alvarez-Sola G, 2017, DIGEST DIS, V35, P158, DOI 10.1159/000450905
   Anderson EJ, 2014, ANTIOXID REDOX SIGN, V21, P1156, DOI 10.1089/ars.2014.5888
   Anderson EJ, 2009, J CLIN INVEST, V119, P573, DOI 10.1172/JCI37048
   Martinez-Gonzalez MA, 2009, NUTR REV, V67, pS111, DOI 10.1111/j.1753-4887.2009.00172.x
   [Anonymous], 2013, Metabolic syndrome: an important risk factor for stroke, Alzheimer disease, and depression
   [Anonymous], 2005, The IDF consensus worldwide definition of the metabolic syndrome
   ANTONETTI DA, 1995, J CLIN INVEST, V95, P1383, DOI 10.1172/JCI117790
   Aubert J, 2011, CLIN RES HEPATOL GAS, V35, P630, DOI 10.1016/j.clinre.2011.04.015
   Aung K, 2014, J CLIN ENDOCR METAB, V99, P462, DOI 10.1210/jc.2013-2832
   Austin S, 2012, J CELL SCI, V125, P4963, DOI 10.1242/jcs.113662
   Bach-Faig A, 2011, PUBLIC HEALTH NUTR, V14, P2274, DOI 10.1017/S1368980011002515
   Baldini F, 2021, LIFE SCI, V265, DOI 10.1016/j.lfs.2020.118812
   Barshad G, 2018, TRENDS GENET, V34, P682, DOI 10.1016/j.tig.2018.05.009
   Baur JA, 2006, NATURE, V444, P337, DOI 10.1038/nature05354
   Bell JA, 2017, INT J OBESITY, V41, P866, DOI 10.1038/ijo.2017.51
   Beltrán-Sánchez H, 2013, J AM COLL CARDIOL, V62, P697, DOI 10.1016/j.jacc.2013.05.064
   Benton CR, 2008, APPL PHYSIOL NUTR ME, V33, P843, DOI 10.1139/H08-074
   Beuther DA, 2010, CURR OPIN PULM MED, V16, P64, DOI 10.1097/MCP.0b013e3283338fa7
   Bhaskaran K, 2014, LANCET, V384, P755, DOI 10.1016/S0140-6736(14)60892-8
   Bhatti JS, 2017, BBA-MOL BASIS DIS, V1863, P1066, DOI 10.1016/j.bbadis.2016.11.010
   Blundell JE, 2014, OBESITY FACTS, V7, P322, DOI 10.1159/000368783
   Bonen A, 2009, APPL PHYSIOL NUTR ME, V34, P307, DOI 10.1139/H09-008
   Bournat Juan C, 2010, Curr Opin Endocrinol Diabetes Obes, V17, P446, DOI 10.1097/MED.0b013e32833c3026
   Brand MD, 2011, BIOCHEM J, V435, P297, DOI 10.1042/BJ20110162
   Brookes PS, 2005, FREE RADICAL BIO MED, V38, P12, DOI 10.1016/j.freeradbiomed.2004.10.016
   Buckland G, 2013, INT J CANCER, V132, P2918, DOI 10.1002/ijc.27958
   Buckland G, 2010, AM J CLIN NUTR, V91, P381, DOI 10.3945/ajcn.2009.28209
   Bugger H, 2008, CLIN SCI, V114, P195, DOI 10.1042/CS20070166
   Calder PC, 2009, BIOCHIMIE, V91, P791, DOI 10.1016/j.biochi.2009.01.008
   Caldwell SH, 1999, J HEPATOL, V31, P430, DOI 10.1016/S0168-8278(99)80033-6
   Camara AKS, 2011, FRONT PHYSIOL, V2, DOI 10.3389/fphys.2011.00013
   Camara AKS, 2010, ANTIOXID REDOX SIGN, V13, P279, DOI 10.1089/ars.2009.2788
   Cantó C, 2009, CURR OPIN LIPIDOL, V20, P98, DOI 10.1097/MOL.0b013e328328d0a4
   Cao K, 2014, FREE RADICAL BIO MED, V67, P396, DOI 10.1016/j.freeradbiomed.2013.11.029
   Capó X, 2015, EUR J NUTR, V54, P35, DOI 10.1007/s00394-014-0683-2
   Carbone F, 2021, EUR J CLIN INVEST, V51, DOI 10.1111/eci.13410
   Castro-Quezada I, 2014, NUTRIENTS, V6, P231, DOI 10.3390/nu6010231
   Catalán V, 2022, NUTRIENTS, V14, DOI 10.3390/nu14081597
   Cauley JA, 2015, J CLIN DENSITOM, V18, P499, DOI 10.1016/j.jocd.2015.04.013
   Centers for Disease Control and Prevention, 2021, OV OB AD OB FACTS
   Chalasani N, 2003, HEPATOLOGY, V37, P544, DOI 10.1053/jhep.2003.50095
   Chang Y, 2012, INT J OBESITY, V36, P1187, DOI 10.1038/ijo.2011.247
   Chaudhuri R, 2019, MECHANISMS AND MANIFESTATIONS OF OBESITY IN LUNG DISEASE, P143, DOI 10.1016/B978-0-12-813553-2.00007-5
   Chen CC, 2016, INT J MOL MED, V37, P743, DOI 10.3892/ijmm.2016.2475
   Chen YR, 2014, CIRC RES, V114, P524, DOI 10.1161/CIRCRESAHA.114.300559
   Choo HJ, 2006, DIABETOLOGIA, V49, P784, DOI 10.1007/s00125-006-0170-2
   Chrysohoou C, 2004, J AM COLL CARDIOL, V44, P152, DOI 10.1016/j.jacc.2004.03.039
   Couto E, 2011, BRIT J CANCER, V104, P1493, DOI 10.1038/bjc.2011.106
   Cuthbertson DJ, 2021, NAT REV ENDOCRINOL, V17, P519, DOI 10.1038/s41574-021-00537-7
   D'Innocenzo S, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061306
   Daussin FN, 2021, NUTRIENTS, V13, DOI 10.3390/nu13103466
   de Ligt M, 2018, MOL METAB, V12, P39, DOI 10.1016/j.molmet.2018.04.004
   de Mello AH, 2018, LIFE SCI, V192, P26, DOI 10.1016/j.lfs.2017.11.019
   De Meyts P, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.760558
   Deng XH, 2019, J FOOD SCI, V84, P2101, DOI 10.1111/1750-3841.14723
   Deschênes D, 2003, OBES RES, V11, P469, DOI 10.1038/oby.2003.64
   Després JP, 2008, ARTERIOSCL THROM VAS, V28, P1039, DOI 10.1161/ATVBAHA.107.159228
   Di Ciaula A, 2022, EUR J CLIN INVEST, V52, DOI 10.1111/eci.13768
   Di Ciaula A, 2021, EUR J CLIN INVEST, V51, DOI 10.1111/eci.13682
   Di Ciaula A, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22147702
   Di Ciaula A, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22105375
   Di Ciaula A, 2020, J CLIN MED, V9, DOI 10.3390/jcm9082648
   Di Ciaula A, 2019, EXPERT REV GASTROENT, V13, P157, DOI 10.1080/17474124.2019.1549988
   Di WC, 2018, CURR ISSUES MOL BIOL, V28, P29, DOI 10.21775/cimb.028.029
   Dikalov S, 2011, FREE RADICAL BIO MED, V51, P1289, DOI 10.1016/j.freeradbiomed.2011.06.033
   Diogo CV, 2011, CURR MED CHEM, V18, P5448
   Dominguez LJ, 2021, NUTRIENTS, V13, DOI 10.3390/nu13062028
   Dominy JE, 2010, BBA-PROTEINS PROTEOM, V1804, P1676, DOI 10.1016/j.bbapap.2009.11.023
   Dong YZ, 2020, J AGR FOOD CHEM, V68, P9377, DOI 10.1021/acs.jafc.0c03310
   Donini LM, 2022, CLIN NUTR, V41, P990, DOI 10.1016/j.clnu.2021.11.014
   Donini LM, 2020, CLIN NUTR, V39, P2368, DOI 10.1016/j.clnu.2019.11.024
   Dontas AS, 2007, CLIN INTERV AGING, V2, P109, DOI 10.2147/ciia.2007.2.1.109
   Okada LSDR, 2018, CLIN NUTR, V37, P1474, DOI 10.1016/j.clnu.2017.08.031
   Drake I, 2018, BRIT J NUTR, V119, P1168, DOI 10.1017/S000711451800079X
   Duluc L, 2014, INT J BIOCHEM CELL B, V53, P9, DOI 10.1016/j.biocel.2014.03.030
   Eckel RH, 2010, LANCET, V375, P181, DOI 10.1016/S0140-6736(09)61794-3
   Estruch R, 2018, NEW ENGL J MED, V378, DOI [10.1056/NEJMoa1800389, 10.1056/NEJMoa1200303, 10.1056/nejmoa1800389]
   Evert AB, 2014, DIABETES CARE, V37, pS120, DOI 10.2337/dc14-S120
   Faienza MF, 2020, WORLD J PEDIATR, V16, P438, DOI 10.1007/s12519-020-00341-9
   Faienza MF, 2016, INTERN EMERG MED, V11, P175, DOI 10.1007/s11739-015-1382-6
   Farooqui A.A., 2012, Phytochemicals, Signal Transduction, and Neurological Disorders
   Farooqui AA, 2012, CELL MOL LIFE SCI, V69, P741, DOI 10.1007/s00018-011-0840-1
   Feng CS, 2016, MOL MED REP, V13, P4205, DOI 10.3892/mmr.2016.5056
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Finicelli M, 2019, J CELL PHYSIOL, V234, P5807, DOI 10.1002/jcp.27506
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Ford ES, 2005, DIABETES CARE, V28, P2745, DOI 10.2337/diacare.28.11.2745
   Fortuño A, 2002, ENDOCRINOLOGY, V143, P3555, DOI 10.1210/en.2002-220075
   Fox CS, 2015, DIABETES CARE, V38, P1777, DOI [10.1161/CIR.0000000000000230, 10.2337/dci15-0012]
   Freeman BA, 2008, J BIOL CHEM, V283, P15515, DOI 10.1074/jbc.R800004200
   Frühbeck G, 2019, OBESITY FACTS, V12, P131, DOI 10.1159/000497124
   Fung TT, 2009, CIRCULATION, V119, P1093, DOI 10.1161/CIRCULATIONAHA.108.816736
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gao X, 2007, AM J CLIN NUTR, V86, P1486, DOI 10.1093/ajcn/86.5.1486
   Gao ZG, 2009, DIABETES, V58, P1509, DOI 10.2337/db08-1637
   Garcia-Marcos L, 2013, PEDIAT ALLERG IMM-UK, V24, P330, DOI 10.1111/pai.12071
   Garcia-Martinez I, 2016, J CLIN INVEST, V126, P859, DOI 10.1172/JCI83885
   Gastaldi G, 2008, Rev Med Suisse, V4, P1387
   Georgousopoulou EN, 2014, HELL J CARDIOL, V55, P24
   Giorgi C, 2018, INT REV CEL MOL BIO, V340, P209, DOI 10.1016/bs.ircmb.2018.05.006
   Goisser S, 2015, CLIN INTERV AGING, V10, DOI 10.2147/CIA.S82454
   Gómez-Ambrosi J, 2017, CLIN NUTR, V36, P861, DOI 10.1016/j.clnu.2016.04.027
   González-Muniesa P, 2017, NAT REV DIS PRIMERS, V3, DOI 10.1038/nrdp.2017.34
   Grattagliano I, 2021, METHODS MOL BIOL, V2310, P201, DOI 10.1007/978-1-0716-1433-4_12
   Grattagliano I, 2019, BIOCHEM PHARMACOL, V160, P34, DOI 10.1016/j.bcp.2018.11.020
   Grattagliano I, 2015, METHODS MOL BIOL, V1241, P137, DOI [10.1007/978-1-4939-1875-1_12, 10.1007/978-1-0716-1433-4_11]
   Grattagliano I, 2011, CURR DRUG TARGETS, V12, P879, DOI 10.2174/138945011795528877
   Grundy SM, 2004, AM J CLIN NUTR, V80, P1
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Gueguen N, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0144290
   Guglielmetti S, 2020, BMC GERIATR, V20, DOI 10.1186/s12877-020-1472-9
   Hales Craig M, 2020, NCHS Data Brief, P1, DOI 10.21608/seaf.2020.162168
   Handschin C, 2006, ENDOCR REV, V27, P728, DOI 10.1210/er.2006-0037
   Hardie DG, 2012, NAT REV MOL CELL BIO, V13, P251, DOI 10.1038/nrm3311
   Hardie DG, 2003, ENDOCRINOLOGY, V144, P5179, DOI 10.1210/en.2003-0982
   Heinonen S, 2015, DIABETES, V64, P3135, DOI 10.2337/db14-1937
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Huo R, 2015, EUR J CLIN NUTR, V69, P1200, DOI 10.1038/ejcn.2014.243
   Islam H, 2018, METABOLISM, V79, P42, DOI 10.1016/j.metabol.2017.11.001
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   James AM, 2012, TRENDS ENDOCRIN MET, V23, P429, DOI 10.1016/j.tem.2012.06.008
   Jezek P, 2005, INT J BIOCHEM CELL B, V37, P2478, DOI 10.1016/j.biocel.2005.05.013
   Jornayvaz FR, 2010, ESSAYS BIOCHEM, V47, P69, DOI [10.1042/bse0470069, 10.1042/BSE0470069]
   Joy JM, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1222-x
   Kahn BB, 2005, CELL METAB, V1, P15, DOI 10.1016/j.cmet.2004.12.003
   Kang CH, 2012, ANN NY ACAD SCI, V1271, P110, DOI 10.1111/j.1749-6632.2012.06738.x
   Karnati S, 2013, HISTOCHEM CELL BIOL, V140, P105, DOI 10.1007/s00418-013-1099-4
   Kastorini CM, 2011, J AM COLL CARDIOL, V57, P1299, DOI 10.1016/j.jacc.2010.09.073
   Keane D, 2013, CURR VASC PHARMACOL, V11, P842, DOI 10.2174/15701611113116660173
   Kelley DE, 2002, DIABETES, V51, P2944, DOI 10.2337/diabetes.51.10.2944
   Keshtzar E, 2016, HUM EXP TOXICOL, V35, P1060, DOI 10.1177/0960327115618247
   Khalil M, 2022, J FUNCT FOODS, V90, DOI 10.1016/j.jff.2022.104993
   Khalil M, 2021, J FUNCT FOODS, V87, DOI 10.1016/j.jff.2021.104811
   Khalil M, 2021, J ETHNOPHARMACOL, V269, DOI 10.1016/j.jep.2020.113748
   Khalil M, 2021, NUTR CANCER, V73, P1193, DOI 10.1080/01635581.2020.1792517
   Kim TN, 2015, J CELL BIOCHEM, V116, P1171, DOI 10.1002/jcb.25077
   Komen JC, 2014, BRIT J PHARMACOL, V171, P1818, DOI 10.1111/bph.12413
   Konopka AR, 2015, DIABETES, V64, P2104, DOI 10.2337/db14-1701
   Kopel E, 2014, ANN INTERN MED, V161, P157, DOI [10.7326/L14-5014, 10.7326/M13-1725, 10.7326/L14-5014-2]
   Krawczyk M, 2011, SEMIN LIVER DIS, V31, P157, DOI 10.1055/s-0031-1276645
   Kühlbrandt W, 2015, BMC BIOL, V13, DOI 10.1186/s12915-015-0201-x
   Kuipers EJ., 2020, ENCY GASTROENTEROLOG, P287, DOI DOI 10.1016/B978-0-12-801238-3.65861-0
   Kusminski CM, 2012, TRENDS ENDOCRIN MET, V23, P435, DOI 10.1016/j.tem.2012.06.004
   La Vecchia C, 2009, NUTR REV, V67, pS126, DOI 10.1111/j.1753-4887.2009.00174.x
   Ladabaum U, 2014, AM J MED, V127, P717, DOI 10.1016/j.amjmed.2014.02.026
   Lagouge M, 2006, CELL, V127, P1109, DOI 10.1016/j.cell.2006.11.013
   Lahera V, 2017, CURR HYPERTENS REP, V19, DOI 10.1007/s11906-017-0710-9
   Landecho MF, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112664
   LAUBINGER W, 1988, BIOCHEMISTRY-US, V27, P7531, DOI 10.1021/bi00419a053
   Lee HY, 2010, CELL METAB, V12, P668, DOI 10.1016/j.cmet.2010.11.004
   Li Y, 2021, FREE RADICAL BIO MED, V162, P523, DOI 10.1016/j.freeradbiomed.2020.11.009
   Liesa M, 2013, CELL METAB, V17, P491, DOI 10.1016/j.cmet.2013.03.002
   Lipinski B, 2011, OXID MED CELL LONGEV, V2011, DOI 10.1155/2011/809696
   Liu J, 2020, FOOD FUNCT, V11, P2535, DOI [10.1039/C9FO03028J, 10.1039/c9fo03028j]
   Liu R, 2020, J NUTR BIOCHEM, V79, DOI 10.1016/j.jnutbio.2019.108330
   Longo M, 2021, METABOLISM, V117, DOI 10.1016/j.metabol.2021.154708
   Lopez-Garcia E, 2014, AM J CLIN NUTR, V99, P172, DOI 10.3945/ajcn.113.068106
   Lu J, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/1260141
   Lu Y, 2014, LANCET, V383, P970, DOI 10.1016/S0140-6736(13)61836-X
   Magriplis E, 2021, NUTRIENTS, V13, DOI 10.3390/nu13082680
   Malik AN, 2013, MITOCHONDRION, V13, P481, DOI 10.1016/j.mito.2012.10.011
   Marrone G, 2021, NUTRIENTS, V13, DOI 10.3390/nu13030817
   Martinez KB, 2017, GUT MICROBES, V8, P130, DOI 10.1080/19490976.2016.1270811
   Martínez-González MA, 2008, BMJ-BRIT MED J, V336, P1348, DOI 10.1136/bmj.39561.501007.BE
   Marventano S, 2015, INT J FOOD SCI NUTR, V66, P611, DOI 10.3109/09637486.2015.1077790
   Matsuzawa Y, 2006, NAT CLIN PRACT CARD, V3, P35, DOI 10.1038/ncpcardio0380
   Mechanick JI, 2020, J AM COLL CARDIOL, V75, P539, DOI 10.1016/j.jacc.2019.11.046
   Medina-Remón A, 2017, BRIT J CLIN PHARMACO, V83, P114, DOI 10.1111/bcp.12986
   Méndez-Sánchez N, 2022, LANCET GASTROENTEROL, V7, P388, DOI 10.1016/S2468-1253(22)00062-0
   Mirmiran P, 2017, APPL PHYSIOL NUTR ME, V42, P326, DOI 10.1139/apnm-2016-0508
   Mitchell T, 2012, FREE RADICAL BIO MED, V52, P838, DOI 10.1016/j.freeradbiomed.2011.12.014
   Mollica MP, 2017, DIABETES, V66, P1405, DOI 10.2337/db16-0924
   Most J, 2016, AM J CLIN NUTR, V104, P215, DOI 10.3945/ajcn.115.122937
   Murphy MP, 2009, BIOCHEM J, V417, P1, DOI 10.1042/BJ20081386
   Nadtochiy SM, 2011, NUTRITION, V27, P733, DOI 10.1016/j.nut.2010.12.006
   Nam SY, 2017, GUT LIVER, V11, P323, DOI 10.5009/gnl15557
   Nisoli E, 2007, CIRC RES, V100, P795, DOI 10.1161/01.RES.0000259591.97107.6c
   Núñez-Córdoba JM, 2009, AM J EPIDEMIOL, V169, P339, DOI 10.1093/aje/kwn335
   Osellame LD, 2012, BEST PRACT RES CL EN, V26, P711, DOI 10.1016/j.beem.2012.05.003
   Oyewole AO, 2015, FASEB J, V29, P4766, DOI 10.1096/fj.15-275404
   Paletas K, 2010, J AM COLL NUTR, V29, P41, DOI 10.1080/07315724.2010.10719815
   Pan JJ, 2018, CELL IMMUNOL, V332, P111, DOI 10.1016/j.cellimm.2018.08.006
   Panagiotakos DB, 2007, ASIA PAC J CLIN NUTR, V16, P331
   Passarella S, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222312620
   Pastor N, 2000, J MOL BIOL, V304, P55, DOI 10.1006/jmbi.2000.4173
   Perez-Ternero C, 2017, J NUTR BIOCHEM, V48, P51, DOI 10.1016/j.jnutbio.2017.06.011
   Petersen KF, 2003, SCIENCE, V300, P1140, DOI 10.1126/science.1082889
   Piccinin E, 2019, NAT REV GASTRO HEPAT, V16, P160, DOI 10.1038/s41575-018-0089-3
   Pirola CJ, 2021, J INTERN MED, V289, P84, DOI 10.1111/joim.13147
   Poirier P, 2006, CIRCULATION, V113, P898, DOI 10.1161/CIRCULATIONAHA.106.171016
   Pollack RM, 2017, J GERONTOL A-BIOL, V72, P1703, DOI 10.1093/gerona/glx041
   Portincasa P., 2022, ATTI RELAZIONI ACCAD, P85
   Portincasa P, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23031105
   Portincasa P, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10010083
   Portincasa P, 2006, LANCET, V368, P230, DOI 10.1016/S0140-6736(06)69044-2
   Portincasa P, 2019, GASTROENTEROL REP, V7, P32, DOI 10.1093/gastro/goy044
   Portincasa P, 2019, J CRIT CARE MED, V5, P6, DOI 10.2478/jccm-2019-0003
   Powell EE, 2021, LANCET, V397, P2212, DOI 10.1016/S0140-6736(20)32511-3
   Prasun P, 2020, BBA-MOL BASIS DIS, V1866, DOI 10.1016/j.bbadis.2020.165838
   Primeau V, 2011, INT J OBESITY, V35, P971, DOI 10.1038/ijo.2010.216
   Putti R, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00109
   Radika Mutlur Krishnamoorthy, 2015, Journal of Basic and Clinical Physiology and Pharmacology, V26, P563, DOI 10.1515/jbcpp-2014-0122
   Ravikiran M, 2010, DIABETES RES CLIN PR, V89, P181, DOI 10.1016/j.diabres.2010.03.010
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Rees K, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009825.pub2
   Richard C, 2013, OBESITY, V21, P51, DOI 10.1002/oby.20239
   Rogge MM, 2009, BIOL RES NURS, V10, P356, DOI 10.1177/1099800408329408
   Rong JX, 2007, DIABETES, V56, P1751, DOI 10.2337/db06-1135
   Rosato V, 2019, EUR J NUTR, V58, P173, DOI 10.1007/s00394-017-1582-0
   Rossi AP, 2016, CLIN NUTR, V35, P199, DOI 10.1016/j.clnu.2015.02.005
   Salamone F, 2012, WORLD J GASTROENTERO, V18, P3862, DOI 10.3748/wjg.v18.i29.3862
   Salas-Salvadó J, 2011, DIABETES CARE, V34, P14, DOI 10.2337/dc10-1288
   Sánchez-Calvo B, 2021, J NUTR BIOCHEM, V94, DOI 10.1016/j.jnutbio.2021.108646
   Sayón-Orea C, 2019, JAMA-J AM MED ASSOC, V322, P1486, DOI 10.1001/jama.2019.14630
   Sazanov LA, 2015, NAT REV MOL CELL BIO, V16, P375, DOI 10.1038/nrm3997
   Scarmeas N, 2009, JAMA-J AM MED ASSOC, V302, P627, DOI 10.1001/jama.2009.1144
   Scarmeas N, 2006, ARCH NEUROL-CHICAGO, V63, P1709, DOI 10.1001/archneur.63.12.noc60109
   Scarpulla RC, 2012, TRENDS ENDOCRIN MET, V23, P459, DOI 10.1016/j.tem.2012.06.006
   SCHATZ G, 1967, ANGEW CHEM INT EDIT, V6, P1035, DOI 10.1002/anie.196710351
   Schröder H, 2004, J NUTR, V134, P3355, DOI 10.1093/jn/134.12.3355
   Schwartz MW, 2017, ENDOCR REV, V38, P267, DOI 10.1210/er.2017-00111
   Seidl SE, 2014, FRONT AGING NEUROSCI, V6, DOI 10.3389/fnagi.2014.00036
   Semple RK, 2004, INT J OBESITY, V28, P176, DOI 10.1038/sj.ijo.0802482
   Shah B, 2018, J AM HEART ASSOC, V7, DOI [10.1161/JAHA.118.011367, 10.1161/jaha.118.011367]
   Shannon CE, 2021, MOL METAB, V45, DOI 10.1016/j.molmet.2020.101154
   Sharma AM, 2009, INT J OBESITY, V33, P289, DOI 10.1038/ijo.2009.2
   Simoes ICM, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9100995
   Simopoulos AP, 2008, EXP BIOL MED, V233, P674, DOI 10.3181/0711-MR-311
   Sofi F, 2008, BMJ-BRIT MED J, V337, DOI 10.1136/bmj.a1344
   Spinelli JB, 2018, NAT CELL BIOL, V20, P745, DOI 10.1038/s41556-018-0124-1
   Srinivasan S, 2017, BBA-BIOENERGETICS, V1858, P602, DOI 10.1016/j.bbabio.2017.01.004
   Stanley WC, 2012, CURR OPIN CLIN NUTR, V15, P122, DOI 10.1097/MCO.0b013e32834fdaf7
   Steckhan N, 2016, NUTRITION, V32, P338, DOI 10.1016/j.nut.2015.09.010
   Storz G, 1999, CURR OPIN MICROBIOL, V2, P188, DOI 10.1016/S1369-5274(99)80033-2
   Stowe DF, 2009, ANTIOXID REDOX SIGN, V11, P1373, DOI 10.1089/ARS.2008.2331
   Strazzullo P, 2008, METABOLISM, V57, P355, DOI 10.1016/j.metabol.2007.10.010
   Sun F, 2013, CURR OPIN STRUC BIOL, V23, P526, DOI 10.1016/j.sbi.2013.06.013
   Szczepaniak LS, 2005, AM J PHYSIOL-ENDOC M, V288, pE462, DOI 10.1152/ajpendo.00064.2004
   Tektonidis TG, 2015, ATHEROSCLEROSIS, V243, P93, DOI 10.1016/j.atherosclerosis.2015.08.039
   Tian SM, 2016, GERIATR GERONTOL INT, V16, P155, DOI 10.1111/ggi.12579
   Tilg H, 2006, NAT REV IMMUNOL, V6, P772, DOI 10.1038/nri1937
   Tsai KL, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700928
   Turner-McGrievy G, 2015, CURR DIABETES REP, V15, DOI 10.1007/s11892-014-0524-y
   Turrens JF, 2003, J PHYSIOL-LONDON, V552, P335, DOI 10.1113/jphysiol.2003.049478
   Upadhyay J, 2018, MED CLIN N AM, V102, P13, DOI 10.1016/j.mcna.2017.08.004
   Valero T, 2014, CURR PHARM DESIGN, V20, P5507, DOI 10.2174/138161282035140911142118
   Vecchié A, 2018, EUR J INTERN MED, V48, P6, DOI 10.1016/j.ejim.2017.10.020
   Velázquez-López L, 2014, BMC PEDIATR, V14, DOI 10.1186/1471-2431-14-175
   Venditti P, 2013, MITOCHONDRION, V13, P71, DOI 10.1016/j.mito.2013.01.008
   Wallace DC, 2018, NAT GENET, V50, P1642, DOI 10.1038/s41588-018-0264-z
   Walsh CT, 2018, CHEM REV, V118, P1460, DOI 10.1021/acs.chemrev.7b00510
   Wang B, 2013, FREE RADICAL BIO MED, V65, P882, DOI 10.1016/j.freeradbiomed.2013.08.173
   Wang DT, 2020, J GERONTOL A-BIOL, V75, P2081, DOI 10.1093/gerona/glaa214
   Wang HH, 2020, PEDIATR GASTROENTERO, V23, P189
   Wang J, 2019, FOOD FUNCT, V10, P2125, DOI [10.1039/c8fo02460j, 10.1039/C8FO02460J]
   Wang JS, 2013, NUTRIENTS, V5, P3910, DOI 10.3390/nu5103910
   Watt IN, 2010, P NATL ACAD SCI USA, V107, P16823, DOI 10.1073/pnas.1011099107
   Wei YZ, 2008, WORLD J GASTROENTERO, V14, P193, DOI 10.3748/wjg.14.193
   Weltman MD, 1996, GASTROENTEROLOGY, V111, P1645, DOI 10.1016/S0016-5085(96)70028-8
   WILLETT WC, 1995, AM J CLIN NUTR, V61, p1402S, DOI 10.1093/ajcn/61.6.1402S
   Wong CY, 2010, DIABETIC MED, V27, P54, DOI 10.1111/j.1464-5491.2009.02869.x
   World Health Organization, ers on effectively addressing overweight and obesity in the
   Wu ZD, 2007, EXPERT OPIN THER TAR, V11, P1329, DOI 10.1517/14728222.11.10.1329
   Yárnoz-Esquiroz P, 2022, EUR J CLIN INVEST, V52, DOI 10.1111/eci.13811
   Yin X, 2014, J CLIN ENDOCR METAB, V99, pE209, DOI 10.1210/jc.2013-3042
   Yoshino J, 2016, PHYSIOL REP, V4, DOI 10.14814/phy2.12785
   Zamani F, 2021, J BIOCHEM MOL TOXIC, V35, DOI 10.1002/jbt.22762
   Zhao RZ, 2019, INT J MOL MED, V44, P3, DOI 10.3892/ijmm.2019.4188
   Zito Francesco Paolo, 2016, World J Gastrointest Pharmacol Ther, V7, P564
   Zorzano A, 2009, INT J BIOCHEM CELL B, V41, P1846, DOI 10.1016/j.biocel.2009.02.004
   Zuo H, 2009, METABOLISM, V58, P1102, DOI 10.1016/j.metabol.2009.04.008
NR 278
TC 36
Z9 36
U1 3
U2 28
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2022
VL 14
IS 15
AR 3112
DI 10.3390/nu14153112
PG 31
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 3S9OS
UT WOS:000839917100001
PM 35956289
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Romero-García, T
   Landa-Galvan, HV
   Pavón, N
   Mercado-Morales, M
   Valdivia, HH
   Rueda, A
AF Romero-Garcia, Tatiana
   Landa-Galvan, Huguet, V
   Pavon, Natalia
   Mercado-Morales, Martha
   Valdivia, Hector H.
   Rueda, Angelica
TI Autonomous activation of CaMKII exacerbates diastolic calcium leak
   during beta-adrenergic stimulation in cardiomyocytes of metabolic
   syndrome rats
SO CELL CALCIUM
LA English
DT Article
DE Ca2+/calmodulin-dependent protein kinase type II; Diastolic Ca(2+)leak;
   Cardiac ryanodine receptor phosphorylation; beta-adrenergic stimulation;
   Metabolic syndrome; High sucrose diet
ID RYANODINE RECEPTOR PHOSPHORYLATION; CARDIAC SARCOPLASMIC-RETICULUM;
   KINASE-II; RYR2 PHOSPHORYLATION; OXIDATIVE STRESS; CA2+ SPARKS; HEART;
   DYSFUNCTION; RELEASE; CONTRIBUTES
AB Autonomous Ca2+/calmodulin-dependent protein kinase II (CaMKII) activation induces abnormal diastolic Ca2+ leak, which leads to triggered arrhythmias in a wide range of cardiovascular diseases, including diabetic cardiomyopathy. In hyperglycemia, Ca2+ handling alterations can be aggravated under stress conditions via the beta-adrenergic signaling pathway, which also involves CaMKII activation. However, little is known about intracellular Ca2+ handling disturbances under beta-adrenergic stimulation in cardiomyocytes of the prediabetic metabolic syndrome (MetS) model with obesity, and the participation of CaMKII in these alterations.
   MetS was induced in male Wistar rats by administering 30 % sucrose in drinking water for 16 weeks. Fluo 3-loaded MetS cardiomyocytes exhibited augmented diastolic Ca2+ leak (in the form of spontaneous Ca2+ waves) under basal conditions and that Ca2+ leakage was exacerbated by isoproterenol (ISO, 100 nM). At the molecular level, [H-3]-ryanodine binding and basal phosphorylation of cardiac ryanodine receptor (RyR2) at Ser2814, a CaMKII site, were increased in heart homogenates of MetS rats with no changes in RyR2 expression. These alterations were not further augmented by Isoproterenol. SERCA pump activity was augmented 48 % in MetS hearts before beta-adrenergic stimuli, which is associated to augmented PLN phosphorylation at T17, a target of CaMKII. In MetS hearts. CaMKII auto-phosphorylation (T287) was increased by 80 %. The augmented diastolic Ca2+ leak was prevented by CaMKII inhibition with AIP. In conclusion, CaMKII autonomous activation in cardiomyocytes of MetS rats with central obesity significantly contributes to abnormal diastolic Ca2+ leak, increasing the propensity for beta-adrenergic receptor-driven lethal arrhythmias.
C1 [Romero-Garcia, Tatiana; Landa-Galvan, Huguet, V; Mercado-Morales, Martha; Rueda, Angelica] IPN, Cinvestav, Ctr Invest & Estudios Avanzados IPN, Dept Biochem, Mexico City 07300, DF, Mexico.
   [Pavon, Natalia] Inst Nacl Cardiol Ignacio Chavez, Dept Pharmacol, Mexico City, DF, Mexico.
   [Valdivia, Hector H.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Div Cardiovasc Med, Madison, WI 53705 USA.
C3 CINVESTAV - Centro de Investigacion y de Estudios Avanzados del
   Instituto Politecnico Nacional; Instituto Politecnico Nacional - Mexico;
   National Institute of Cardiology - Mexico; University of Wisconsin
   System; University of Wisconsin Madison
RP Rueda, A (corresponding author), IPN, Cinvestav, Dept Biochem, Av IPN 2508, Mexico City 07360, DF, Mexico.
EM arueda@cinvestav.mx
RI Rueda, Angelica/G-4055-2012
OI Rueda, Angelica/0000-0001-8749-8494; Pavon, Natalia/0000-0002-8520-5077;
   Romero-Garcia, Tatiana/0000-0003-4316-2248; VALDIVIA,
   HECTOR/0000-0003-1231-6267
FU Fundacion Miguel Aleman A. C.; Fondo SEP-Cinvestav approved project
   [601410 FIDSC 2018/2]; Fondo SEP-Conacyt Ciencia Basica [A1-S-9082];
   PRODEP-SEP grant [28915/2018]; NIH [R01-HL055438, R01-HL134344]
FX This work was partially supported by Fundacion Miguel Aleman A. C., and
   Fondo SEP-Cinvestav approved project #601410 FIDSC 2018/2 to R, A; Fondo
   SEP-Conacyt Ciencia Basica A1-S-9082 to R, A; by a PRODEP-SEP grant to
   the Academic Group CINVESTAV-CA-10, ID 28915/2018 and by NIH grants
   R01-HL055438 and R01-HL134344 to V, HH. R, A was a COMEXUS-Fulbright
   Fellow to perform a research stay at Hector H. Valdivia laboratory
   (Center for Arrhythmia Research, University of Michigan Ann Arbor, MI,
   USA); R-G, T and L-G, H were CONACYT Ph.D. fellows.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Arellano-Campos O, 2019, BMC ENDOCR DISORD, V19, DOI 10.1186/s12902-019-0361-8
   Balderas-Villalobos J, 2013, AM J PHYSIOL-HEART C, V305, pH1344, DOI 10.1152/ajpheart.00211.2013
   Bartolommei G, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0058615
   Bers DM, 2014, ANNU REV PHYSIOL, V76, P107, DOI 10.1146/annurev-physiol-020911-153308
   Biesmans L, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025100
   Bovo E, 2015, CELL CALCIUM, V58, P246, DOI 10.1016/j.ceca.2015.06.002
   Cabré JJ, 2008, BMC PUBLIC HEALTH, V8, DOI 10.1186/1471-2458-8-251
   Camors E, 2014, FRONT PHARMACOL, V5, DOI 10.3389/fphar.2014.00101
   Cárdenas G, 2006, CLIN EXP HYPERTENS, V28, P85, DOI 10.1080/10641960500468235
   Carvajal K, 2003, MOL CELL BIOCHEM, V249, P157, DOI 10.1023/A:1024799025126
   Carvajal K, 1999, J HYPERTENS, V17, P1607, DOI 10.1097/00004872-199917110-00015
   de Alba-Aguayo DR, 2017, CELL CALCIUM, V62, P29, DOI 10.1016/j.ceca.2017.01.009
   De Koninck P, 1998, SCIENCE, V279, P227, DOI 10.1126/science.279.5348.227
   De Pergola G, 2008, OBESITY, V16, P2405, DOI 10.1038/oby.2008.382
   Dincer UD, 2006, J MOL CELL CARDIOL, V41, P108, DOI 10.1016/j.yjmcc.2006.04.018
   Dincer UD, 2012, DIABETES METAB SYNDR, V5, P89, DOI 10.2147/DMSO.S30005
   Eisner D, 2014, EXP PHYSIOL, V99, P1273, DOI 10.1113/expphysiol.2013.077305
   Erickson JR, 2014, FRONT PHARMACOL, V5, DOI 10.3389/fphar.2014.00059
   Erickson JR, 2013, NATURE, V502, P372, DOI 10.1038/nature12537
   Federico M, 2017, J PHYSIOL-LONDON, V595, P4089, DOI 10.1113/JP273714
   Fernández-Miranda G, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00520
   Fernández-Sada E, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/7682569
   Fernández-Velasco M, 2009, CIRC RES, V104, P201, DOI 10.1161/CIRCRESAHA.108.177493
   Gomez AM, 1996, J PHYSIOL-LONDON, V496, P575, DOI 10.1113/jphysiol.1996.sp021708
   Grimm M, 2015, J MOL CELL CARDIOL, V85, P282, DOI 10.1016/j.yjmcc.2015.06.007
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   GRYNKIEWICZ G, 1985, J BIOL CHEM, V260, P3440
   Guo T, 2012, CIRC RES, V111, P28, DOI 10.1161/CIRCRESAHA.112.265652
   Han TS, 2016, JRSM CARDIOVASC DIS, V5, DOI 10.1177/2048004016633371
   Hegyi B, 2019, J MOL CELL CARDIOL, V127, P246, DOI 10.1016/j.yjmcc.2019.01.001
   Huke S, 2008, BIOCHEM BIOPH RES CO, V376, P80, DOI 10.1016/j.bbrc.2008.08.084
   Huke S, 2007, J MOL CELL CARDIOL, V42, P590, DOI 10.1016/j.yjmcc.2006.12.007
   Jiang DW, 2004, P NATL ACAD SCI USA, V101, P13062, DOI 10.1073/pnas.0402388101
   Koval OM, 2012, CIRCULATION, V126, P2084, DOI 10.1161/CIRCULATIONAHA.112.105320
   KRANIAS EG, 1980, BIOCHEMISTRY-US, V19, P5434, DOI 10.1021/bi00564a044
   Kranias EG, 2012, CIRC RES, V110, P1646, DOI 10.1161/CIRCRESAHA.111.259754
   Kumari N, 2018, LIFE SCI, V194, P139, DOI 10.1016/j.lfs.2017.12.033
   Landstrom AP, 2017, CIRC RES, V120, P1969, DOI 10.1161/CIRCRESAHA.117.310083
   Li J, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0058334
   LINDEMANN JP, 1983, J BIOL CHEM, V258, P464
   Liu NA, 2011, J MOL CELL CARDIOL, V50, P214, DOI 10.1016/j.yjmcc.2010.10.001
   Manna P, 2015, METAB SYNDR RELAT D, V13, P423, DOI 10.1089/met.2015.0095
   Mattiazzi A, 2014, FRONT PHARMACOL, V5, DOI 10.3389/fphar.2014.00005
   Miklós Z, 2012, ACTA PHYSIOL, V205, P381, DOI 10.1111/j.1748-1716.2012.02420.x
   Ninomiya JK, 2004, CIRCULATION, V109, P42, DOI 10.1161/01.CIR.0000108926.04022.0C
   Oda T, 2015, J MOL CELL CARDIOL, V85, P240, DOI 10.1016/j.yjmcc.2015.06.009
   Okatan EN, 2016, CAN J PHYSIOL PHARM, V94, P1064, DOI 10.1139/cjpp-2015-0531
   Pereira L, 2014, CELL CALCIUM, V56, P372, DOI 10.1016/j.ceca.2014.08.004
   Respress JL, 2012, CIRC RES, V110, P1474, DOI 10.1161/CIRCRESAHA.112.268094
   Rodriguez P, 2003, J BIOL CHEM, V278, P38593, DOI 10.1074/jbc.C301180200
   Roe ND, 2013, FREE RADICAL BIO MED, V65, P234, DOI 10.1016/j.freeradbiomed.2013.06.042
   Salazar MR, 2014, J AM SOC HYPERTENS, V8, P724, DOI 10.1016/j.jash.2014.08.002
   Santiago DJ, 2013, BIOPHYS J, V104, P976, DOI 10.1016/j.bpj.2013.01.026
   Sommese L, 2016, INT J CARDIOL, V202, P394, DOI 10.1016/j.ijcard.2015.09.022
   Swaminathan PD, 2011, J CLIN INVEST, V121, P3277, DOI 10.1172/JCI57833
   Tune JD, 2017, TRANSL RES, V183, P57, DOI 10.1016/j.trsl.2017.01.001
   Venetucci LA, 2007, CIRC RES, V100, P105, DOI 10.1161/01.RES.0000252828.17939.00
   Vest RS, 2007, MOL BIOL CELL, V18, P5024, DOI 10.1091/mbc.E07-02-0185
   Zarain-Herzberg A, 2014, CELL CALCIUM, V56, P302, DOI 10.1016/j.ceca.2014.09.005
NR 61
TC 5
Z9 6
U1 0
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0143-4160
EI 1532-1991
J9 CELL CALCIUM
JI Cell Calcium
PD NOV
PY 2020
VL 91
AR 102267
DI 10.1016/j.ceca.2020.102267
PG 13
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA SW8UO
UT WOS:000664790900014
PM 32920522
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chis, BA
   Chis, AF
   Muresan, A
   Fodor, D
AF Chis, Bogdan Augustin
   Chis, Ana Florica
   Muresan, Adriana
   Fodor, Daniela
TI Q10 Coenzyme Supplementation can Improve Oxidative Stress Response to
   Exercise in Metabolic Syndrome in Rats
SO INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
LA English
DT Article
DE Metabolic syndrome; Q10 coenzyme; malondialdehyde; thiol groups; chronic
   exercise
ID LIPID-PEROXIDATION; INSULIN-RESISTANCE; CARBOHYDRATE; DISEASE; MARKERS;
   PROTEIN; DIETS; Q(10)
AB Background: The metabolic syndrome leads to high morbidity and mortality. Almost all pathological states are associated with oxidative stress (OS) disorders. This study evaluates the effects of Coenzyme Q10 (CoQ10) supplementation on different lifestyles, in relation to serum and tissue OS parameters. Materials and methods: Twelve Wistar rat groups (10 rats/group) were equally divided in three types of diets: standard (St), high fat (HF), high sugar (HS); within each diet group there was one sedentary group with CoQ10 supplementation (100 mg/kg body weight), one sedentary without CoQ10, one trained group with CoQ10 and one trained group without CoQ10 supplementation. After 28 days blood samples were collected as follows: after 12 hours of fasting (TO), 1 hour postprandial (T1) and after 1 hour of exercise (T2) or sedentary postprandial time (T3). Thiol groups (SH) and malondialdehyde (MDA) were determined from serum and liver homogenate. Results: Significant changes were observed in fasting MDA for HF (p = 0.024 for training, 0.028 for CoQ10). Postprandial, OS status altered, with highest MDA in HF sedentary non-CoQ10 group (3.92 +/- 0.37 vs 2.67 +/- 0.41 nmol/ml in St trained CoQ10). At T2 the untrained and non-Coal 0 groups had the highest MDA levels (up to 22.3% vs T1, p < 0.001 in HF) as SH dropped (34.4% decrease vs T1, p < 0.001 in HF). At T3 high MDA levels were observed, correlated with low SH (Pearson r = -0.423 overall), irrespective of the CoQ10 supplementation. CoQ10 improved the liver OS status (MDA and SH decreased), but not the exercise, in all diets. Conclusions: CoQ10 supplementation accompanied by chronic exercise improved the OS serum profile, irrespective of the daily diet. CoQ10 lowered liver MDA and SH concentrations.
C1 [Chis, Bogdan Augustin; Fodor, Daniela] Iuliu Hatieganu Univ Med & Pharm, Dept Internal Med 2, Cluj Napoca, Romania.
   [Chis, Ana Florica] Iuliu Hatieganu Univ Med & Pharm, Dept Pulmonol, Cluj Napoca, Romania.
   [Muresan, Adriana] Iuliu Hatieganu Univ Med & Pharm, Physiol Dept, Cluj Napoca, Romania.
C3 Iuliu Hatieganu University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy; Iuliu Hatieganu University of
   Medicine & Pharmacy
RP Chis, BA (corresponding author), Iuliu Hatieganu Univ Med & Pharm, Internal Med Dept 2, Cluj Cty Emergency Hosp, Clin 2-4 St, Cluj Napoca 400006, Romania.
EM bogdan_a_chis@yahoo.com
RI Chis, Bogdan/AAE-5898-2022; Chis, Ana/HJH-7780-2023
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alehagen U, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0157541
   Bell David S H, 2008, Endocr Pract, V14, P112
   Bellinger AM, 2008, P NATL ACAD SCI USA, V105, P2198, DOI 10.1073/pnas.0711074105
   Boutcher SH, 2011, J OBES, V2011, DOI 10.1155/2011/868305
   Chis B.A, 2011, CLUJUL MED, V84, P23
   Cicero AFG, 2016, J HYPERTENS, V34, pE109, DOI 10.1097/01.hjh.0000491621.83495.00
   Cooke M, 2008, J INT SOC SPORT NUTR, V5, DOI 10.1186/1550-2783-5-8
   Di Massimo C, 2004, CLIN HEMORHEOL MICRO, V30, P313
   Ercan H, 2016, METAB SYNDR RELAT D, V14, P318, DOI 10.1089/met.2016.0011
   Esterbauer H, 1994, METHOD ENZYMOL, V186, P406
   Fatani SH, 2016, DIABETES METAB SYND, V10, pS64, DOI 10.1016/j.dsx.2016.01.028
   Fisher-Wellman KH, 2010, INT J SPORT NUTR EXE, V20, P393, DOI 10.1123/ijsnem.20.5.393
   Fong JJ, 2006, ANN PHARMACOTHER, V40, P461, DOI 10.1345/aph.1E636
   Forsberg E, 2015, J DIABETES COMPLICAT, V29, P1152, DOI 10.1016/j.jdiacomp.2015.08.006
   Garber AJ, 2012, HEART FAIL CLIN, V8, P563, DOI 10.1016/j.hfc.2012.06.004
   Gems D, 2008, CELL METAB, V7, P200, DOI 10.1016/j.cmet.2008.01.001
   Hosoe K, 2007, REGUL TOXICOL PHARM, V47, P19, DOI 10.1016/j.yrtph.2006.07.001
   HU ML, 1994, METHOD ENZYMOL, V233, P380
   Ji LL, 2008, FREE RADICAL BIO MED, V44, P142, DOI 10.1016/j.freeradbiomed.2007.02.031
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kitabchi AE, 2013, DIABETES CARE, V36, P1919, DOI 10.2337/dc12-1912
   Kregel K., 2006, Resource Book for the Design of Animal Exercise Protocols, P23, DOI [10.2460/ajvr.68.6.583, DOI 10.2460/AJVR.68.6.583]
   Leeuwenburgh C, 2001, CURR MED CHEM, V8, P829, DOI 10.2174/0929867013372896
   Liu YX, 2015, J ETHNOPHARMACOL, V162, P244, DOI 10.1016/j.jep.2014.12.040
   Milagro FI, 2006, OBESITY, V14, P1118, DOI 10.1038/oby.2006.128
   Milne GL, 2007, METHOD ENZYMOL, V433, P113, DOI 10.1016/S0076-6879(07)33006-1
   Moazen M, 2015, J PAK MED ASSOC, V65, P404
   Munshi RP, 2014, INDIAN J PHARMACOL, V46, P270, DOI 10.4103/0253-7613.132156
   Niklowitz P, 2016, J CLIN BIOCHEM NUTR, V58, P240, DOI 10.3164/jcbn.15-73
   Nordmann AJ, 2006, ARCH INTERN MED, V166, P285, DOI 10.1001/archinte.166.3.285
   Patel VP, 2011, INT J CLIN EXP PATHO, V4, P215
   Pryor WA, 2000, FREE RADICAL BIO MED, V28, P141, DOI 10.1016/S0891-5849(99)00224-5
   Radak Z, 2016, FREE RADICAL BIO MED, V98, P187, DOI 10.1016/j.freeradbiomed.2016.01.024
   Ramond A, 2013, FUND CLIN PHARMACOL, V27, P252, DOI 10.1111/j.1472-8206.2011.01015.x
   Raygan F, 2016, EUR J NUTR, V55, P2357, DOI 10.1007/s00394-015-1042-7
   Sies H, 1997, EXP PHYSIOL, V82, P291, DOI 10.1113/expphysiol.1997.sp004024
   The University of Texas at Austin, 2013, GUID US CERV DISL RO, P12
   Yubero-Serrano EM, 2013, AGE, V35, P159, DOI 10.1007/s11357-011-9331-4
   Yubero-Serrano EM, 2011, AGE, V33, P579, DOI 10.1007/s11357-010-9199-8
NR 40
TC 5
Z9 5
U1 1
U2 5
PU VERLAG HANS HUBER
PI BERN 9
PA LANGGASS-STRASSE 76, CH-3000 BERN 9, SWITZERLAND
SN 0300-9831
EI 1664-2821
J9 INT J VITAM NUTR RES
JI Int. J. Vitam. Nutr. Res.
PD JAN
PY 2020
VL 90
IS 1-2
BP 33
EP 41
DI 10.1024/0300-9831/a000301
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA KH7XA
UT WOS:000510862200005
PM 30887903
DA 2025-06-11
ER

PT J
AU Cepelova, M
   Kruseova, J
   Luks, A
   Capek, V
   Cepela, P
   Potockova, J
   Kraml, P
AF Cepelova, M.
   Kruseova, J.
   Luks, A.
   Capek, V.
   Cepela, P.
   Potockova, J.
   Kraml, P.
TI Accelerated atherosclerosis, hyperlipoproteinemia and insulin resistance
   in long-term survivors of Hodgkin lymphoma during childhood and
   adolescence
SO NEOPLASMA
LA English
DT Article
DE Hodgkin lymphoma; long-term survivors; hyperlipoproteinemia; insulin
   resistance; metabolic syndrome; intima-media thickness
ID INTIMA-MEDIA THICKNESS; ACUTE LYMPHOBLASTIC-LEUKEMIA; YOUNG-ADULT
   SURVIVORS; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; 5-YEAR SURVIVORS;
   SCIENTIFIC STATEMENT; CAROTID ULTRASOUND; DIABETES-MELLITUS; OXIDATIVE
   STRESS
AB Long-term survivors of Hodgkin lymphoma during childhood or adolescence (HL survivors) are at high risk of developing treatment-related late cardiovascular sequelae. In our study we evaluated the presence of modifiable cardiovascular risk factors (hypertension, hyperlipoproteinemia, hyperinsulinemia, obesity), endothelial and inflammatory markers (E-selectin, PAI-1, hs-CRP) and atherosclerotic changes in the common carotid arteries. Assessment was performed in 80 young adult Hodgkin lymphoma long-term survivors at more than 10 years after the potentially cardiovascular toxic anticancer treatment (median age at evaluation 34.7 years; range 24.1-40.9 years). The HL survivors were compared with 83 age- and gender-matched healthy volunteers. The HL survivors showed unfavorable lipid profiles compared to those of healthy controls: triglycerides (p=0.01), total cholesterol (p=0.0004), low density lipoprotein cholesterol (p=0.005). In HL survivors, we found a higher prevalence of hypertension (p=0.004) and insulin resistance - HOMA-IR (p=0.0002). Ultrasonographic examination of both common carotid arteries revealed a higher prevalence of atherosclerotic plaques (p=0.0009) and higher carotid intima-media thickness (p<0.0001) in HL survivors. Markers of oxidative stress (advanced oxidation protein products, oxidized low-density lipoprotein), inflammation (hs-CRP) and endothelial dysfunction (E-selectin, PAI-1) were also higher in HL survivors (p<0.0001, p=0.0002, p=0.0031, p=0.0087, p=0.004, respectively). Adult survivors of Hodgkin lymphoma during childhood and adolescence need closer follow-up with screening of metabolic syndrome components, unfavorable lifestyle factors and early management of these risk factors.
C1 [Cepelova, M.; Kruseova, J.; Luks, A.; Capek, V.] Charles Univ Prague, Med Fac 2, Dept Pediat Hematol & Oncol, Prague, Czech Republic.
   [Cepelova, M.; Kruseova, J.; Luks, A.; Capek, V.] Univ Hosp Motol, Prague, Czech Republic.
   [Cepela, P.; Potockova, J.; Kraml, P.] Charles Univ Prague, Med Fac 3, Internal Clin 2, Prague, Czech Republic.
   [Cepela, P.; Potockova, J.; Kraml, P.] Kralovske Vinohrady Univ Hosp, Prague, Czech Republic.
C3 Charles University Prague; Motol University Hospital; Charles University
   Prague; University Hospital Vinohrady
RP Cepelova, M (corresponding author), Charles Univ Prague, Med Fac 2, Dept Pediat Hematol & Oncol, Prague, Czech Republic.; Cepelova, M (corresponding author), Univ Hosp Motol, Prague, Czech Republic.
EM michaela.cepelova@fnmotol.cz
RI Luks, Ales/G-7201-2015; Cepelova, Michaela/AAM-7116-2021; Kruseova,
   Jarmila/AAS-1036-2021; Capek, Vaclav/D-8555-2016
OI Capek, Vaclav/0000-0002-8574-7001
FU Ministry of Health of the Czech Republic [NV15-30494A]
FX This study was supported by grant NV15-30494A from the Ministry of
   Health of the Czech Republic. The authors would like to thank the HL
   survivors and healthy volunteers for their kind cooperation in this
   study, Dirk Hasenclever, Institute for Medical Informatics, Statistics
   and Epidemiology - IMISE, Leipzig University, Germany, for valuable
   advice.
CR Adly AAM, 2014, J DIABETES COMPLICAT, V28, P340, DOI 10.1016/j.jdiacomp.2014.01.011
   ANDERSON MT, 1994, P NATL ACAD SCI USA, V91, P11527, DOI 10.1073/pnas.91.24.11527
   Ariffin H, 2017, CANCER-AM CANCER SOC, V123, P4207, DOI 10.1002/cncr.30857
   Armstrong GT, 2009, J CLIN ONCOL, V27, P2328, DOI 10.1200/JCO.2008.21.1425
   Berry JD, 2012, NEW ENGL J MED, V366, P321, DOI 10.1056/NEJMoa1012848
   Biondi B, 2004, ENDOCRINE, V24, P1, DOI 10.1385/ENDO:24:1:001
   Bornfeldt KE, 2011, CELL METAB, V14, P575, DOI 10.1016/j.cmet.2011.07.015
   Bowers DC, 2005, J CLIN ONCOL, V23, P6508, DOI 10.1200/JCO.2005.15.107
   Brouwer CAJ, 2013, J CLIN ONCOL, V31, P3906, DOI 10.1200/JCO.2012.46.6086
   Carnethon MR, 2005, JAMA-J AM MED ASSOC, V294, P2981, DOI 10.1001/jama.294.23.2981
   Cavallini MC, 1996, ANN INTERN MED, V124, P877, DOI 10.7326/0003-4819-124-10-199605150-00003
   De Bruin ML, 2009, JNCI-J NATL CANCER I, V101, P928, DOI 10.1093/jnci/djp147
   de Lemos ET, 2012, OXID MED CELL LONGEV, V2012, DOI 10.1155/2012/741545
   De Lucia RolfeE., 2010, Obesity, V18, P625, DOI DOI 10.1038/0BY.2009.309
   Delitala AP, 2015, NUTR METAB CARDIOVAS, V25, P1104, DOI 10.1016/j.numecd.2015.09.001
   Duncan GE, 2003, DIABETES CARE, V26, P557, DOI 10.2337/diacare.26.3.557
   Facchini FS, 2000, FREE RADICAL BIO MED, V29, P1302, DOI 10.1016/S0891-5849(00)00438-X
   Floriani C, 2018, EUR HEART J, V39, P503, DOI 10.1093/eurheartj/ehx050
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Gurney JG, 2006, CANCER-AM CANCER SOC, V107, P1303, DOI 10.1002/cncr.22120
   Haddy TB, 2007, PEDIATR BLOOD CANCER, V49, P79, DOI 10.1002/pbc.20886
   Hopps E, 2010, NUTR METAB CARDIOVAS, V20, P72, DOI 10.1016/j.numecd.2009.06.002
   Jones DP, 2008, PEDIATR BLOOD CANCER, V51, P724, DOI 10.1002/pbc.21695
   Kavey REW, 2006, CIRCULATION, V114, P2710, DOI 10.1161/CIRCULATIONAHA.106.179568
   Kawamura S, 2005, J HEALTH SCI, V51, P385, DOI 10.1248/jhs.51.385
   Khovidhunkit W, 2004, J LIPID RES, V45, P1169, DOI 10.1194/jlr.R300019-JLR200
   Kim H, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0182090
   Lipshultz SE, 2013, CIRCULATION, V128, P1927, DOI 10.1161/CIR.0b013e3182a88099
   Lorenz MW, 2007, CIRCULATION, V115, P459, DOI 10.1161/CIRCULATIONAHA.106.628875
   Meacham LR, 2010, CANCER EPIDEM BIOMAR, V19, P170, DOI 10.1158/1055-9965.EPI-09-0555
   Mertens AC, 2008, JNCI-J NATL CANCER I, V100, P1368, DOI 10.1093/jnci/djn310
   Mertens I, 2002, Obes Rev, V3, P85, DOI 10.1046/j.1467-789X.2002.00056.x
   Mitsumura H, 2014, J STROKE CEREBROVASC, V23, P1391, DOI 10.1016/j.jstrokecerebrovasdis.2013.11.015
   Mulrooney DA, 2009, BMJ-BRIT MED J, V339, DOI 10.1136/bmj.b4606
   Neville KA, 2006, J CLIN ENDOCR METAB, V91, P4401, DOI 10.1210/jc.2006-0128
   Nuver J, 2002, CANCER TREAT REV, V28, P195, DOI 10.1016/S0305-7372(02)00038-5
   Oeffinger KC, 2003, J CLIN ONCOL, V21, P1359, DOI 10.1200/JCO.2003.06.131
   Oeffinger KC, 2009, J CLIN ONCOL, V27, P3698, DOI 10.1200/JCO.2008.19.7251
   Polak JF, 2011, NEW ENGL J MED, V365, P213, DOI 10.1056/NEJMoa1012592
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Rodondi N, 2010, JAMA-J AM MED ASSOC, V304, P1365, DOI 10.1001/jama.2010.1361
   Roos A, 2007, J CLIN ENDOCR METAB, V92, P491, DOI 10.1210/jc.2006-1718
   Rutter MM, 2007, CURR OPIN PEDIATR, V19, P480, DOI 10.1097/MOP.0b013e3282058b56
   Saini A, 2006, CYTOKINE GROWTH F R, V17, P475, DOI 10.1016/j.cytogfr.2006.09.006
   Sarti C, 2006, J DIABETES COMPLICAT, V20, P121, DOI 10.1016/j.jdiacomp.2005.06.014
   Saultier P, 2016, HAEMATOLOGICA, V101, P1603, DOI 10.3324/haematol.2016.148908
   Schäfer K, 2003, ARTERIOSCL THROM VAS, V23, P2097, DOI 10.1161/01.ATV.0000097766.36623.DF
   Sies H, 2017, ANNU REV BIOCHEM, V86, P715, DOI 10.1146/annurev-biochem-061516-045037
   Stein JH, 2008, J AM SOC ECHOCARDIOG, V21, P93, DOI 10.1016/j.echo.2007.11.011
   Steinberger J, 2012, J PEDIATR-US, V160, P494, DOI 10.1016/j.jpeds.2011.08.018
   Sulicka J, 2013, IMMUNOBIOLOGY, V218, P810, DOI 10.1016/j.imbio.2012.09.003
   Sun J, 2017, INT J ENDOCRINOL, V2017, DOI 10.1155/2017/8130796
   Talvensaari KK, 1996, J CLIN ENDOCR METAB, V81, P3051, DOI 10.1210/jc.81.8.3051
   Tukenova M, 2010, J CLIN ONCOL, V28, P1308, DOI 10.1200/JCO.2008.20.2267
   Vega GL, 2006, J CLIN ENDOCR METAB, V91, P4459, DOI 10.1210/jc.2006-0814
   Wajchenberg BL, 2000, ENDOCR REV, V21, P697, DOI 10.1210/er.21.6.697
NR 56
TC 11
Z9 11
U1 0
U2 6
PU AEPRESS SRO
PI BRATISLAVA
PA BAJZOVA 7, BRATISLAVA, 821 08, SLOVAKIA
SN 0028-2685
EI 1338-4317
J9 NEOPLASMA
JI Neoplasma
PY 2019
VL 66
IS 6
BP 978
EP 987
DI 10.4149/neo_2019_190115N45
PG 10
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA JR5EW
UT WOS:000499649200013
PM 31305124
OA Bronze
DA 2025-06-11
ER

PT J
AU van Tienhoven-Wind, LJN
   Gruppen, EG
   James, RW
   Bakker, SJL
   Gans, ROB
   Dullaart, RPF
AF van Tienhoven-Wind, Lynnda J. N.
   Gruppen, Eke G.
   James, Richard W.
   Bakker, Stephan J. L.
   Gans, Rijk O. B.
   Dullaart, Robin P. F.
TI Serum paraoxonase-1 activity is inversely related to free thyroxine in
   euthyroid subjects: The PREVEND Cohort Study
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE free thyroxine; high-density lipoproteins; metabolic syndrome;
   paraoxonase-1; thyroid function
ID LOW-DENSITY-LIPOPROTEIN; INTIMA-MEDIA THICKNESS; C-REACTIVE PROTEIN;
   OXIDATIVE STRESS; METABOLIC SYNDROME; THYROID-FUNCTION; ANTIOXIDATIVE
   FUNCTIONALITY; CARDIOVASCULAR-DISEASE; I ACTIVITY; HYPOTHYROIDISM
AB BackgroundLow-normal thyroid function within the euthyroid range has been suggested to enhance atherosclerosis susceptibility. Paraoxonase-1 (PON-1) may protect against atherosclerotic cardiovascular disease development by attenuating oxidative stress. We evaluated relationships of PON-1 with thyroid stimulating hormone (TSH), free T-4, free T-3, lipids and apolipoprotein (apo)A-I in euthyroid subjects, and assessed whether such relationships are modified in the context of the metabolic syndrome (MetS).
   Materials and methodsSerum PON-1 activity (arylesterase activity), TSH, free T-4, free T-3, lipids and apoA-I was measured in 2206 euthyroid subjects (aged 28-75years; 1138 men (age 4913years) and 1068 women (age 4612years), recruited from the general population (PREVEND cohort).
   ResultsIn age- and sex-adjusted analysis, PON-1 activity (divided into tertiles) was positively related to TSH (=-0.045, P=.036) and inversely to free T-4 (=-0.042, P=.050) but not to free T-3 (=-0.027, P=.20). PON-1 activity was positively related to total cholesterol, non-HDL cholesterol and triglycerides, as well as to HDL cholesterol and apoA-I (P<.01 to <.001). The inverse relationship of PON-1 activity with free T-4 remained present after adjustment for lipids and other potential confounders (=-0.066, P=.002), but the positive relationship with TSH lost significance (=0.034, P=.11). The inverse relationship of PON-1 activity with free T-4 was not different in subjects with vs without MetS (P=.94), nor modified by the presence of its individual components (P.22 for each).
   ConclusionsSerum PON-1 activity is inversely associated with free T-4 in euthyroid subjects, suggesting that low-normal thyroid function may affect PON-1 regulation.
C1 [van Tienhoven-Wind, Lynnda J. N.; Gruppen, Eke G.; Bakker, Stephan J. L.; Gans, Rijk O. B.; Dullaart, Robin P. F.] Univ Med Ctr Groningen, Dept Internal Med, Groningen, Netherlands.
   [van Tienhoven-Wind, Lynnda J. N.; Gruppen, Eke G.; Bakker, Stephan J. L.; Gans, Rijk O. B.; Dullaart, Robin P. F.] Univ Groningen, Groningen, Netherlands.
   [James, Richard W.] Univ Geneva, Fac Med, Dept Internal Med, Geneva, Switzerland.
C3 University of Groningen; University of Groningen; University of Geneva
RP van Tienhoven-Wind, LJN (corresponding author), Univ Med Ctr Groningen, Dept Nephrol AA53, Groningen, Netherlands.
EM L.J.N.van.Tienhoven-Wind@umcg.nl
RI ; Bakker, Stephan/J-4023-2015
OI Gans, Reinold/0000-0001-5481-2387; Bakker, Stephan/0000-0003-3356-6791
FU Dutch Kidney Foundation [E.033]; Dade Behring; Ausam; Roche; Abbott;
   Dutch Heart Foundation
FX The Dutch Kidney Foundation supported the infrastructure of the PREVEND
   program from 1997 to 2003 (Grant E.033). The Groningen University
   Medical Center supported the infrastructure from 2003 to 2006. Dade
   Behring, Ausam, Roche and Abbott, financed laboratory equipment and
   reagents by which various laboratory determinations could be performed.
   Richard W. James conducted the assays for paraoxonase-1 activity in
   PREVEND. The Dutch Heart Foundation supported studies on lipid
   metabolism (2001-2005).
CR Ates I, 2016, EUR J ENDOCRINOL, V174, P727, DOI 10.1530/EJE-15-1061
   Aviram M, 1999, FREE RADICAL BIO MED, V26, P892, DOI 10.1016/S0891-5849(98)00272-X
   Azizi F, 2003, J ENDOCRINOL INVEST, V26, P703, DOI 10.1007/BF03347350
   Baskol G, 2007, EXP CLIN ENDOCR DIAB, V115, P522, DOI 10.1055/s-2007-981457
   Bhattacharyya T, 2008, JAMA-J AM MED ASSOC, V299, P1265, DOI 10.1001/jama.299.11.1265
   Carlioglu A, 2014, ARCH GYNECOL OBSTET, V290, P929, DOI 10.1007/s00404-014-3275-8
   Cebeci E, 2012, J INVEST MED, V60, P23, DOI 10.2310/JIM.0b013e31823581dd
   Corsetti JP, 2014, J AM SOC NEPHROL, V25, P2906, DOI 10.1681/ASN.2013121256
   Costantini F, 1998, ARTERIOSCL THROM VAS, V18, P732, DOI 10.1161/01.ATV.18.5.732
   Deakin S, 2005, ATHEROSCLEROSIS, V179, P17, DOI 10.1016/j.atherosclerosis.2004.08.039
   Deakin SP, 2004, CLIN SCI, V107, P435, DOI 10.1042/CS20040187
   Deetman PE, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0090886
   Dullaart RPF, 2009, EUR J CLIN INVEST, V39, P200, DOI 10.1111/j.1365-2362.2009.02090.x
   Dullaart RPF, 2007, CLIN ENDOCRINOL, V67, P668, DOI 10.1111/j.1365-2265.2007.02943.x
   Dullaart RPF, 2013, ATHEROSCLEROSIS, V230, P6, DOI 10.1016/j.atherosclerosis.2013.06.019
   Dullaart RPF, 2009, CLIN ENDOCRINOL, V70, P221, DOI 10.1111/j.1365-2265.2008.03306.x
   Fülöp P, 2016, CHEM-BIOL INTERACT, V259, P388, DOI 10.1016/j.cbi.2016.04.003
   Garin MCB, 2006, J LIPID RES, V47, P515, DOI 10.1194/jlr.M500281-JLR200
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Halbesma N, 2008, KIDNEY INT, V74, P505, DOI 10.1038/ki.2008.200
   Huen K, 2009, CLIN CHIM ACTA, V402, P67, DOI 10.1016/j.cca.2008.12.019
   Inker LA, 2012, NEW ENGL J MED, V367, P20, DOI 10.1056/NEJMoa1114248
   Ittermann T, 2012, CLIN ENDOCRINOL, V76, P526, DOI 10.1111/j.1365-2265.2011.04186.x
   Kappelle PJWH, 2012, EUR J CLIN INVEST, V42, P487, DOI 10.1111/j.1365-2362.2011.02604.x
   Karabina SAP, 2005, BBA-GEN SUBJECTS, V1725, P213, DOI 10.1016/j.bbagen.2005.07.005
   Kebapcilar L, 2010, MED SCI MONITOR, V16, pCR41
   Kim BJ, 2009, CLIN ENDOCRINOL, V70, P152, DOI 10.1111/j.1365-2265.2008.03304.x
   Kim DS, 2013, LIPIDS HEALTH DIS, V12, DOI 10.1186/1476-511X-12-183
   Kowalska K, 2017, J CLIN LAB ANAL
   Kraemer HC, 2004, INT J METH PSYCH RES, V13, P141, DOI 10.1002/mpr.170
   Kudchodkar BJ, 2000, J NUTR, V130, P2427, DOI 10.1093/jn/130.10.2427
   Kumon Y, 2002, AMYLOID, V9, P160, DOI 10.3109/13506120209114817
   Kunutsor SK, 2016, ATHEROSCLEROSIS, V245, P143, DOI 10.1016/j.atherosclerosis.2015.12.021
   MACKNESS MI, 1991, ATHEROSCLEROSIS, V86, P193, DOI 10.1016/0021-9150(91)90215-O
   MACKNESS MI, 1993, ATHEROSCLEROSIS, V104, P129, DOI 10.1016/0021-9150(93)90183-U
   Milionis HJ, 2005, THYROID, V15, P455, DOI 10.1089/thy.2005.15.455
   Richter RJ, 2009, TOXICOL APPL PHARM, V235, P1, DOI 10.1016/j.taap.2008.11.001
   Roos A, 2007, J CLIN ENDOCR METAB, V92, P491, DOI 10.1210/jc.2006-1718
   Selvin S., 1996, STAT ANAL EPIDEMIOLO, V2nd
   Senti; Mariano, 2003, Eur J Intern Med, V14, P178, DOI 10.1016/S0953-6205(03)00041-4
   Shieh G, 2011, BRIT J MATH STAT PSY, V64, P462, DOI 10.1111/j.2044-8317.2010.02002.x
   Shih DM, 1998, NATURE, V394, P284, DOI 10.1038/28406
   Sigal GA, 2011, THYROID, V21, P347, DOI 10.1089/thy.2010.0313
   Simera I, 2010, EUR J CLIN INVEST, V40, P35, DOI 10.1111/j.1365-2362.2009.02234.x
   Soran H, 2009, CURR OPIN LIPIDOL, V20, P265, DOI 10.1097/MOL.0b013e32832ec141
   Sundaram V, 1997, J CLIN ENDOCR METAB, V82, P3421, DOI 10.1210/jcem.82.10.4315
   Sutherland WHF, 1999, ARTERIOSCL THROM VAS, V19, P1340, DOI 10.1161/01.ATV.19.5.1340
   Taylor PN, 2013, J CLIN ENDOCR METAB, V98, P3562, DOI 10.1210/jc.2013-1315
   Tomás M, 2000, ARTERIOSCL THROM VAS, V20, P2113, DOI 10.1161/01.ATV.20.9.2113
   Triolo M, 2013, CLIN ENDOCRINOL, V79, P416, DOI 10.1111/cen.12138
   Tward A, 2002, CIRCULATION, V106, P484, DOI 10.1161/01.CIR.0000023623.87083.4F
   van den Berg EH, 2017, METABOLISM, V67, P62, DOI 10.1016/j.metabol.2016.11.002
   van Himbergen TM, 2008, ATHEROSCLEROSIS, V199, P408, DOI 10.1016/j.atherosclerosis.2007.11.018
   van Himbergen TM, 2005, J LIPID RES, V46, P445, DOI 10.1194/jlr.M400052-JLR200
   van Tienhoven-Wind LJN, 2017, HORM METAB RES, V49, P95, DOI 10.1055/s-0042-119211
   van Tienhoven-Wind L, 2015, CLIN BIOCHEM, V48, P489, DOI 10.1016/j.clinbiochem.2015.01.015
   van Tienhoven-Wind LJN, 2015, NUTRIENTS, V7, P1352, DOI 10.3390/nu7021352
   Wang FR, 2012, J CLIN ENDOCR METAB, V97, P2724, DOI 10.1210/jc.2012-1133
   Weetman AP, 2004, CLIN ENDOCRINOL, V61, P405, DOI 10.1111/j.1365-2265.2004.02085.x
   Zhang YY, 2014, ARTERIOSCL THROM VAS, V34, P2128, DOI 10.1161/ATVBAHA.114.303889
NR 60
TC 1
Z9 1
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD JAN
PY 2018
VL 48
IS 1
AR e12860
DI 10.1111/eci.12860
PG 10
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA FR1ZO
UT WOS:000418866800006
PM 29171874
OA Green Published
DA 2025-06-11
ER

PT J
AU Rabie, EM
   Heeba, GH
   Abouzied, MM
   Khalifa, MMA
AF Rabie, Esraa M.
   Heeba, Gehan H.
   Abouzied, Mekky M.
   Khalifa, Mohamed M. A.
TI Comparative effects of Aliskiren and Telmisartan in high fructose
   diet-induced metabolic syndrome in rats
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Metabolic syndrome; Insulin resistance; Fructose; Telmisartan; Aliskiren
ID RENIN-ANGIOTENSIN SYSTEM; TYPE-1 RECEPTOR BLOCKER; FACTOR-KAPPA-B;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; NONALCOHOLIC STEATOHEPATITIS;
   ADIPOSE-TISSUE; DIABETIC-RATS; LIVER-INJURY; WEIGHT-GAIN
AB Fructose is a commonly used sweetener associated with diets that increase the prevalence of metabolic syndrome (MS). Inhibition of the Fenin-angiotensin system (RAS) has been consistently demonstrated to reduce MS. However, there has been 110 direct comparison among different pharmacological modes of inhibiting the RAS concerning their effects on MS. This study investigated the effect of aliskiren, a direct renin inhibitor, versus telmisailan, an angiotensin If-receptor blocked, in the treatment of fructose-induced MS in rats. MS was induced by high fructose (FRC) diet feeding for 12 weeks. Oral administrations of telmisartan (TEL, 5 mg/kg), aliskiren (ALS, 30 mg/kg) or vehicle were started in the last 4 weeks. Results showed that administration of either TEL or ALS with FRC diet equally ameliorated the metabolic parameters (glucose level, oral glucose tolerance test, insulin resistance and serum lipids profile), systolic blood pressure and oxidative stress markers (malondialdehyde, nitric oxide, reduced ! glutathione levels and catalase activity). Additionally, the effects of TEL and ALS were associated with a decrease in body composition index and attenuation of liver index, serum liver enzyme activities and hepatic expressions of inflammatory and fibrotic markers (tumor necrosis factor-a, nuclear factor kappaB and transforming growth factor-beta) with a significant increase in hepatic glucose transporter-2 and peroxisome proliferator-activated receptors-alpha and gamma expressions. The results suggested that, at indicated dosage, ALS has ameliorative effect equal to that of TEL against FRC-induced metabolic and hepatic disorders; implying that drugs which inhibit the RAS, by different mode of inhibition, profoundly affect fructose-induced MS in rats. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Rabie, Esraa M.; Heeba, Gehan H.; Khalifa, Mohamed M. A.] Menia Univ, Fac Pharm, Dept Pharmacol & Toxicol, El Minia 61111, Egypt.
   [Abouzied, Mekky M.] Menia Univ, Fac Pharm, Dept Biochem, El Minia 61111, Egypt.
C3 Egyptian Knowledge Bank (EKB); Minia University; Egyptian Knowledge Bank
   (EKB); Minia University
RP Heeba, GH (corresponding author), Menia Univ, Fac Pharm, Dept Pharmacol & Toxicol, El Minia 61111, Egypt.
EM ghhh70@yahoo.com
RI Khalifa, Mohamed/HGE-8087-2022; Heeba, Gehan/H-7245-2019
OI Abouzied, mekky/0000-0001-5309-3552; Heeba, Gehan H./0000-0002-6907-4441
CR Arab HH, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0097193
   Araki K, 2006, HYPERTENSION, V48, P51, DOI 10.1161/01.HYP.0000225402.69580.1d
   Benson SC, 2004, HYPERTENSION, V43, P993, DOI 10.1161/01.HYP.0000123072.34629.57
   Berger J, 2002, ANNU REV MED, V53, P409, DOI 10.1146/annurev.med.53.082901.104018
   BEUTLER E, 1963, J LAB CLIN MED, V61, P882
   Botezelli JD, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-78
   Boustany CM, 2004, AM J PHYSIOL-REG I, V287, pR943, DOI 10.1152/ajpregu.00265.2004
   Chou CL, 2013, HYPERTENS RES, V36, P123, DOI 10.1038/hr.2012.124
   Chou CL, 2011, ARCH MED SCI, V7, P882, DOI 10.5114/aoms.2011.25566
   de Kloet AD, 2010, PHYSIOL BEHAV, V100, P525, DOI 10.1016/j.physbeh.2010.03.018
   Fouad AA, 2012, TOXICOLOGY, V300, P149, DOI 10.1016/j.tox.2012.06.015
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Frigolet ME, 2013, J NUTR BIOCHEM, V24, P2003, DOI 10.1016/j.jnutbio.2013.07.002
   Fujita K, 2007, DIGEST DIS SCI, V52, P3455, DOI 10.1007/s10620-007-9741-4
   Gandhi S, 2013, J RENIN-ANGIO-ALDO S, V14, P3, DOI 10.1177/1470320312452766
   Geetha R, 2014, MOL CELL BIOCHEM, V387, P123, DOI 10.1007/s11010-013-1877-2
   Grundy SM, 2004, ARTERIOSCL THROM VAS, V24, pE13, DOI 10.1161/01.ATV.0000111245.75752.C6
   Guillemain G, 2000, J CELL SCI, V113, P841
   Habibi J, 2008, ENDOCRINOLOGY, V149, P5643, DOI 10.1210/en.2008-0070
   Hassanin A, 2014, PAK J PHARM SCI, V27, P767
   Iwai M, 2010, J HYPERTENS, V28, P1471, DOI 10.1097/HJH.0b013e32833bc420
   Kelishadi R, 2014, NUTRITION, V30, P503, DOI 10.1016/j.nut.2013.08.014
   Kim S, 1997, HYPERTENSION, V30, P1054, DOI 10.1161/01.HYP.30.5.1054
   Knorr M, 2011, ARTERIOSCL THROM VAS, V31, P2223, DOI 10.1161/ATVBAHA.111.232058
   Kretowicz M, 2011, INT J NEPHROL, V2011, DOI 10.4061/2011/315879
   Kudo H, 2009, LIVER INT, V29, P988, DOI 10.1111/j.1478-3231.2009.02006.x
   Lee KC, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0077817
   Lee KC, 2012, EUR J CLIN INVEST, V42, P1261, DOI 10.1111/j.1365-2362.2012.02725.x
   Lu H, 2008, J CLIN INVEST, V118, P984, DOI 10.1172/JCI32970
   Mamikutty N, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/263897
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mollnau H, 2013, N-S ARCH PHARMACOL, V386, P405, DOI 10.1007/s00210-013-0842-7
   Mori Y, 2007, AM J HYPERTENS, V20, P431, DOI 10.1016/j.amjhyper.2006.09.016
   Naderali EK, 2003, ATHEROSCLEROSIS, V166, P253, DOI 10.1016/S0021-9150(02)00367-2
   Nakagami H, 2010, INT J MOL MED, V26, P477, DOI 10.3892/ijmm_00000488
   Nakano A, 2009, HYPERTENS RES, V32, P765, DOI 10.1038/hr.2009.95
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   Rong X., 2010, DIABETOLOGIA
   Sanchez-Lozada LG, 2007, AM J PHYSIOL-RENAL, V292, pF423, DOI 10.1152/ajprenal.00124.2006
   Sastry KVH, 2002, ANAL BIOCHEM, V306, P79, DOI 10.1006/abio.2002.5676
   Shiuchi T, 2004, HYPERTENSION, V43, P1003, DOI 10.1161/01.HYP.0000125142.41703.64
   Singh VP, 2008, DIABETES, V57, P3297, DOI 10.2337/db08-0805
   Stucchi P, 2009, BRIT J PHARMACOL, V158, P771, DOI 10.1111/j.1476-5381.2009.00355.x
   Sugimoto K, 2006, HYPERTENSION, V47, P1003, DOI 10.1161/01.HYP.0000215181.60228.f7
   Takaya T, 2006, ATHEROSCLEROSIS, V186, P402, DOI 10.1016/j.atherosclerosis.2005.08.009
   Tamaki Y, 2013, J GASTROENTEROL, V48, P491, DOI 10.1007/s00535-012-0651-7
   Tappy L, 2012, CLIN RES HEPATOL GAS, V36, P554, DOI 10.1016/j.clinre.2012.06.005
   Tian Q, 2009, HYPERTENSION, V53, P798, DOI 10.1161/HYPERTENSIONAHA.108.126656
   Tran LT, 2009, MOL CELL BIOCHEM, V332, P145, DOI 10.1007/s11010-009-0184-4
   Wallace TM, 2004, DIABETES CARE, V27, P1487, DOI 10.2337/diacare.27.6.1487
   Yamagishi S, 2005, MED HYPOTHESES, V64, P476, DOI 10.1016/j.mehy.2004.09.015
   Yin SN, 2014, ENDOCR RES, V39, P67, DOI 10.3109/07435800.2013.828741
   Yoshiji H, 2006, HEPATOL RES, V36, P124, DOI 10.1016/j.hepres.2006.07.003
   Zelber-Sagi S, 2011, WORLD J GASTROENTERO, V17, P3377, DOI 10.3748/wjg.v17.i29.3377
NR 54
TC 28
Z9 28
U1 0
U2 16
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD AUG 5
PY 2015
VL 760
BP 145
EP 153
DI 10.1016/j.ejphar.2015.04.019
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CJ7HB
UT WOS:000355664200018
PM 25917321
OA Bronze
DA 2025-06-11
ER

PT J
AU Najjar, S
   Pahlajani, S
   De Sanctis, V
   Stern, JNH
   Najjar, A
   Chong, D
AF Najjar, Souhel
   Pahlajani, Silky
   De Sanctis, Virginia
   Stern, Joel N. H.
   Najjar, Amanda
   Chong, Derek
TI Neurovascular Unit Dysfunction and Blood-Brain Barrier Hyperpermeability
   Contribute to Schizophrenia Neurobiology: A Theoretical integration of
   Clinical and experimental evidence
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE schizophrenia; blood-brain barrier; neurovascular unit; endothelial
   cell; neuroinflammation; oxidative stress; nitric oxide synthase;
   endothelial nitric oxide synthase
ID NITRIC-OXIDE SYNTHASE; ASTROCYTE-ENDOTHELIAL INTERACTIONS;
   CONVERTING-ENZYME-ACTIVITY; CELL-ADHESION MOLECULE-1; OXIDATIVE STRESS;
   METABOLIC SYNDROME; WHITE-MATTER; ATYPICAL ANTIPSYCHOTICS; UNMEDICATED
   PATIENTS; ONSET SCHIZOPHRENIA
AB Schizophrenia is a psychotic disorder characterized by delusions, hallucinations, negative symptoms, as well as behavioral and cognitive dysfunction. It is a pathoetiologically heterogeneous disorder involving complex interrelated mechanisms that include oxidative stress and neuroinflammation. Neurovascular endothelial dysfunction and blood- brain barrier (BBB) hyperpermeability are established mechanisms in neurological disorders with comorbid psychiatric symptoms such as epilepsy, traumatic brain injury, and Alzheimer's disease. Schizophrenia is frequently comorbid with medical conditions associated with peripheral vascular endothelial dysfunction, such as metabolic syndrome, cardiovascular disease, and diabetes mellitus. However, the existence and etiological relevance of neurovascular endothelial dysfunction and BBB hyperpermeability in schizophrenia are still not well recognized. Here, we review the growing clinical and experimental evidence, indicating that neurovascular endotheliopathy and BBB hyperpermeability occur in schizophrenia patients. We present a theoretical integration of human and animal data linking oxidative stress and neuroinflammation to neurovascular endotheliopathy and BBB breakdown in schizophrenia. These abnormalities may contribute to the cognitive and behavioral symptoms of schizophrenia via several mechanisms involving reduced cerebral perfusion and impaired homeostatic processes of cerebral microenvironment. Furthermore, BBB disruption can facilitate interactions between brain innate and peripheral adaptive immunity, thereby perpetuating harmful neuroimmune signals and toxic neuroinflammatory responses, which can also contribute to the symptoms of schizophrenia. Taken together, these findings support the "mild encephalitis" hypothesis of schizophrenia. If neurovascular abnormalities prove to be etiologically relevant to the neurobiology of schizophrenia, then targeting these abnormalities may represent a promising therapeutic strategy.
C1 [Najjar, Souhel; Stern, Joel N. H.; Chong, Derek] Hofstra Northwell Sch Med, Dept Neurol, New York, NY USA.
   [Najjar, Souhel; Pahlajani, Silky; De Sanctis, Virginia; Stern, Joel N. H.] Lenox Hill Hosp, Dept Neurol, Neuroinflammat Div, New York, NY 10021 USA.
   [Najjar, Amanda] Vanderbilt Univ, Peabody Coll, Dept Psychol & Human Dev, Nashville, TN 37203 USA.
C3 Northwell Health; Northwell Health; Vanderbilt University; Vanderbilt
   University Peabody College
RP Najjar, S (corresponding author), Hofstra Northwell Sch Med, Dept Neurol, New York, NY USA.; Najjar, S (corresponding author), Lenox Hill Hosp, Dept Neurol, Neuroinflammat Div, New York, NY 10021 USA.
EM mna1024231@aol.com
OI Stern, Joel N.H./0000-0002-1259-2256
CR Abbott NJ, 2006, NAT REV NEUROSCI, V7, P41, DOI 10.1038/nrn1824
   Abbott NJ, 2002, J ANAT, V200, P629, DOI 10.1046/j.1469-7580.2002.00064.x
   Aboul-Fotouh S, 2013, CAN J PHYSIOL PHARM, V91, P1119, DOI 10.1139/cjpp-2013-0185
   Aliev G, 2003, NEUROTOX RES, V5, P491, DOI 10.1007/BF03033159
   Aliev G, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/962984
   Anderson G, 2013, PROG NEURO-PSYCHOPH, V42, P1, DOI 10.1016/j.pnpbp.2012.10.008
   Andrew PJ, 1999, CARDIOVASC RES, V43, P521, DOI 10.1016/S0008-6363(99)00115-7
   Antoniades C, 2006, CIRCULATION, V114, P1193, DOI 10.1161/CIRCULATIONAHA.106.612325
   Attwell D, 2010, NATURE, V468, P232, DOI 10.1038/nature09613
   Bechter K, 2013, FORTSCHR NEUROL PSYC, V81, P250, DOI 10.1055/s-0033-1335253
   Bechter K, 2010, J PSYCHIATR RES, V44, P321, DOI 10.1016/j.jpsychires.2009.08.008
   Betzen C, 2009, FREE RADICAL BIO MED, V47, P1212, DOI 10.1016/j.freeradbiomed.2009.07.034
   Block ML, 2007, NAT REV NEUROSCI, V8, P57, DOI 10.1038/nrn2038
   Bloomfield PS, 2016, AM J PSYCHIAT, V173, P44, DOI 10.1176/appi.ajp.2015.14101358
   Boyer L, 2014, PSYCHONEUROENDOCRINO, V50, P95, DOI 10.1016/j.psyneuen.2014.07.019
   Burghardt KJ, 2014, J PSYCHOPHARMACOL, V28, P349, DOI 10.1177/0269881113516200
   Chen CA, 2010, NATURE, V468, P1115, DOI 10.1038/nature09599
   Chen WG, 2010, BIOCHEMISTRY-US, V49, P3129, DOI 10.1021/bi9016632
   Chuang Yao-Chung, 2010, Acta Neurol Taiwan, V19, P3
   Coughlin JM, 2013, MOL PSYCHIATR, V18, P10, DOI 10.1038/mp.2012.6
   D'Mello C, 2014, BRAIN BEHAV IMMUN, V35, P9, DOI 10.1016/j.bbi.2013.10.009
   Devanarayanan S, 2016, CLIN CHEM LAB MED, V54, P447, DOI 10.1515/cclm-2015-0212
   Devaraj S, 2009, CURR OPIN LIPIDOL, V20, P182, DOI 10.1097/MOL.0b013e32832ac03e
   Dietrich JB, 2002, J NEUROIMMUNOL, V128, P58, DOI 10.1016/S0165-5728(02)00114-5
   Doorduin J, 2009, J NUCL MED, V50, P1801, DOI 10.2967/jnumed.109.066647
   Ellingrod VL, 2011, SCHIZOPHR RES, V130, P20, DOI 10.1016/j.schres.2011.03.031
   Enciu AM, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/297512
   Fernandez-Egea E, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0155631
   Flatow J, 2013, BIOL PSYCHIAT, V74, P400, DOI 10.1016/j.biopsych.2013.03.018
   Fleegal-DeMotta MA, 2009, J CEREBR BLOOD F MET, V29, P640, DOI 10.1038/jcbfm.2008.158
   Förstermann U, 2006, BIOL CHEM, V387, P1521, DOI 10.1515/BC.2006.190
   Friedman Alon, 2011, Cardiovasc Psychiatry Neurol, V2011, P431470, DOI 10.1155/2011/431470
   Gadelha A, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.181
   Gadelha A, 2015, PSYCHIAT RES, V229, P702, DOI 10.1016/j.psychres.2015.08.018
   Gadelha A, 2013, J PSYCHIATR RES, V47, P657, DOI 10.1016/j.jpsychires.2013.01.009
   GALEA E, 1992, P NATL ACAD SCI USA, V89, P10945, DOI 10.1073/pnas.89.22.10945
   Grove T, 2015, SCHIZOPHR RES, V164, P115, DOI 10.1016/j.schres.2015.02.006
   Hafizi S, 2017, AM J PSYCHIAT, V174, P118, DOI 10.1176/appi.ajp.2016.16020171
   Haraldsen G, 1996, J IMMUNOL, V156, P2558
   Harris LW, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003964
   Hayashi MAF, 2015, CURR PROTEIN PEPT SC, V16, P754, DOI 10.2174/1389203716666150505225251
   Henninger DD, 1997, J IMMUNOL, V158, P1825
   Hino M, 2016, J PSYCHIATR RES, V82, P100, DOI 10.1016/j.jpsychires.2016.07.018
   Huang ZH, 1996, J CEREBR BLOOD F MET, V16, P981, DOI 10.1097/00004647-199609000-00023
   Israel AK, 2011, SCHIZOPHR RES, V128, P44, DOI 10.1016/j.schres.2011.02.007
   Iwata Y, 2007, SCHIZOPHR RES, V89, P154, DOI 10.1016/j.schres.2006.08.026
   Jin R, 2011, STROKE, V42, P2033, DOI 10.1161/STROKEAHA.110.601369
   Kagota S, 2013, MICROVASC RES, V88, P70, DOI 10.1016/j.mvr.2013.04.001
   Kandratavicius L, 2015, J NEUROINFLAMM, V12, DOI 10.1186/s12974-015-0266-z
   Katsel P, 2011, NEUROPSYCHOPHARMACOL, V36, P1171, DOI 10.1038/npp.2010.252
   Kawakami K, 2014, NEUROPSYCHOBIOLOGY, V69, P202, DOI 10.1159/000358840
   Kenk M, 2015, SCHIZOPHRENIA BULL, V41, P85, DOI 10.1093/schbul/sbu157
   Kettenmann H, 2011, PHYSIOL REV, V91, P461, DOI 10.1152/physrev.00011.2010
   Khan M, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-78
   Khandaker GM, 2016, PSYCHOPHARMACOLOGY, V233, P1559, DOI 10.1007/s00213-015-3975-1
   Kumar A, 2008, PEDIATRICS, V122, pE722, DOI 10.1542/peds.2008-0269
   Lakhan SE, 2013, FRONT NEUROL, V4, DOI 10.3389/fneur.2013.00032
   Lavoie KL, 2010, PSYCHOSOM MED, V72, P20, DOI 10.1097/PSY.0b013e3181c2d6b8
   Lehner C, 2011, ANTIOXID REDOX SIGN, V15, P1305, DOI 10.1089/ars.2011.3923
   Lencz T, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3739
   Lepeta K, 2015, SCHIZOPHRENIA BULL, V41, P1003, DOI 10.1093/schbul/sbv036
   Liu P, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.144
   Liu VWT, 2008, CARDIOVASC RES, V77, P19, DOI 10.1016/j.cardiores.2007.06.024
   Lochhead JJ, 2010, J CEREBR BLOOD F MET, V30, P1625, DOI 10.1038/jcbfm.2010.29
   Maes M, 2011, J AFFECT DISORDERS, V135, P414, DOI 10.1016/j.jad.2011.08.023
   Malaspina D, 2004, BIOL PSYCHIAT, V56, P931, DOI 10.1016/j.biopsych.2004.09.013
   Masopust J, 2011, BMC PSYCHIATRY, V11, DOI 10.1186/1471-244X-11-2
   Milleit B, 2016, FRONT CELL NEUROSCI, V10, DOI 10.3389/fncel.2016.00033
   Miller BJ, 2013, BIOL PSYCHIAT, V73, P993, DOI 10.1016/j.biopsych.2012.09.007
   Miller BJ, 2011, BIOL PSYCHIAT, V70, P663, DOI 10.1016/j.biopsych.2011.04.013
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P295, DOI 10.1093/schbul/sbs082
   Mogi M, 2012, INT J HYPERTENS, V2012, DOI 10.1155/2012/169649
   Müller N, 2015, FRONT NEUROSCI-SWITZ, V9, DOI 10.3389/fnins.2015.00372
   Najjar S, 2015, SCHIZOPHR RES, V161, P102, DOI 10.1016/j.schres.2014.04.041
   Najjar S, 2013, J NEUROINFLAMM, V10, DOI 10.1186/1742-2094-10-142
   Najjar S, 2013, J NEUROINFLAMM, V10, DOI 10.1186/1742-2094-10-43
   Ng F, 2008, INT J NEUROPSYCHOPH, V11, P851, DOI 10.1017/S1461145707008401
   Notter T, 2018, MOL PSYCHIATR, V23, P323, DOI 10.1038/mp.2016.248
   Onore CE, 2012, BIOL PSYCHIAT, V72, P1020, DOI 10.1016/j.biopsych.2012.05.004
   Ott M, 2007, APOPTOSIS, V12, P913, DOI 10.1007/s10495-007-0756-2
   Pasternak O, 2012, J NEUROSCI, V32, P17365, DOI 10.1523/JNEUROSCI.2904-12.2012
   Pillai A, 2016, MOL PSYCHIATR, V21, P686, DOI 10.1038/mp.2015.96
   Prat A, 2000, J NEUROPATH EXP NEUR, V59, P896, DOI 10.1093/jnen/59.10.896
   Pun PBL, 2009, FREE RADICAL RES, V43, P348, DOI 10.1080/10715760902751902
   Reale M, 2011, BMC NEUROSCI, V12, DOI 10.1186/1471-2202-12-13
   Rybakowski JK, 2009, SCHIZOPHR RES, V109, P90, DOI 10.1016/j.schres.2009.02.005
   Samdani AF, 1997, STROKE, V28, P1283, DOI 10.1161/01.STR.28.6.1283
   Scheef L, 2010, RADIOLOGY, V256, P253, DOI 10.1148/radiol.10091224
   Schwartz M, 2006, TRENDS NEUROSCI, V29, P68, DOI 10.1016/j.tins.2005.12.005
   Serlin Yonatan, 2011, Cardiovasc Psychiatry Neurol, V2011, P609202, DOI 10.1155/2011/609202
   Shalev Hadar, 2009, Cardiovasc Psychiatry Neurol, V2009, P278531, DOI 10.1155/2009/278531
   Steiner J, 2006, ACTA NEUROPATHOL, V112, P305, DOI 10.1007/s00401-006-0090-8
   Strzelecki D, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17071075
   Stuehr DJ, 2004, J BIOL CHEM, V279, P36167, DOI 10.1074/jbc.R400017200
   Suzuki Y, 2015, J CEREBR BLOOD F MET, V35, P2021, DOI 10.1038/jcbfm.2015.167
   Szabo C, 2007, NAT REV DRUG DISCOV, V6, P662, DOI 10.1038/nrd2222
   Takahashi Y, 2016, FRONT CELL NEUROSCI, V10, DOI 10.3389/fncel.2016.00144
   Takano A, 2010, INT J NEUROPSYCHOPH, V13, P943, DOI 10.1017/S1461145710000313
   Uranova NA, 2010, WORLD J BIOL PSYCHIA, V11, P567, DOI 10.3109/15622970903414188
   van Berckel BN, 2008, BIOL PSYCHIAT, V64, P820, DOI 10.1016/j.biopsych.2008.04.025
   Wake R, 2016, EUR ARCH PSY CLIN N, V266, P3, DOI 10.1007/s00406-015-0607-z
   Yarlagadda Atmaram, 2009, Psychiatry (Edgmont), V6, P18
   Zhang JP, 2013, SCHIZOPHR RES, V146, P285, DOI 10.1016/j.schres.2013.01.020
NR 103
TC 147
Z9 152
U1 1
U2 19
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD MAY 23
PY 2017
VL 8
AR 83
DI 10.3389/fpsyt.2017.00083
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EW2BN
UT WOS:000402301600001
PM 28588507
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Thompson, JA
   Webb, RC
AF Thompson, Jennifer A.
   Webb, R. Clinton
TI Potential role of Toll-like receptors in programming of vascular
   dysfunction
SO CLINICAL SCIENCE
LA English
DT Article
DE developmental programming; metabolic syndrome; oxidative stress;
   pro-inflammation; Toll-like receptor
ID INTRAUTERINE GROWTH RESTRICTION; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   ADULT HYPERTENSION; BIRTH-WEIGHT; MOUSE MODEL; INNATE; INFLAMMATION;
   TOLL-LIKE-RECEPTOR-4; INHIBITION
AB The developmental origins of the metabolic syndrome have been established through the consistent observation that small-for-gestational age and large-for-gestational age fetuses have an increased risk for hypertension and related metabolic disorders later in life. These phenotypes have been reproduced in various species subjected to a range of intrauterine insults and ongoing research is directed towards understanding the underlying molecular mechanisms. Current evidence suggests that the creation of a pro-inflammatory and pro-oxidant intrauterine milieu is a common thread among prenatal factors that have an impact upon fetal size. Furthermore, studies demonstrate that a shift in fetal redox status consequent to environmental cues persists after birth and drives the progression of vascular dysfunction and hypertension in postnatal life. TLR (Toll-like receptor) signalling has emerged as a key link between inflammation and oxidative stress and a pathogenic contributor to hypertension, insulin resistance and obesity, in both human patients and animal models of disease. Thus TLR activation and dysregulation of its signalling components represent potential molecular underpinnings of programmed hypertension and related disorders in those subjected to suboptimal intrauterine conditions, yet their contributions to developmental programming remain unexplored. We propose that danger signals mobilized by the placenta or fetal tissues during complicated pregnancy activate the fetal innate immune system through TLRs and thereby potentiate the generation of ROS (reactive oxygen species) and orchestrate fetal adaptive responses, including changes in gene expression, which later translate to vascular dysfunction. Furthermore, we suggest that, after birth, continual activation of TLR signalling propagates vascular oxidative stress and thereby accelerates the advancement of hypertension and heart failure.
C1 [Thompson, Jennifer A.; Webb, R. Clinton] Georgia Regents Univ, MCG Dept Physiol, Augusta, GA 30912 USA.
C3 University System of Georgia; Augusta University
RP Thompson, JA (corresponding author), Georgia Regents Univ, MCG Dept Physiol, 1120 15th St, Augusta, GA 30912 USA.
EM jthompson2@gru.edu
OI Thompson, Jennifer/0000-0003-0421-3719
FU National Institutes of Health [DK-83685]; Society for Women's Health
   Research
FX Our own work was supported by the National Institutes of Health [grant
   number DK-83685] and the Society for Women's Health Research
CR Andersson U, 2011, ANNU REV IMMUNOL, V29, P139, DOI 10.1146/annurev-immunol-030409-101323
   Bavdekar A, 1999, DIABETES, V48, P2422, DOI 10.2337/diabetes.48.12.2422
   Ben Mkaddem S, 2010, ONCOTARGET, V1, P741, DOI 10.18632/oncotarget.209
   Bertucci MC, 2011, REPROD FERT DEVELOP, V23, P346, DOI 10.1071/RD10110
   Bomfim GF, 2012, CLIN SCI, V122, P535, DOI 10.1042/CS20110523
   Boney CM, 2005, PEDIATRICS, V115, pE290, DOI 10.1542/peds.2004-1808
   Burton GJ, 2009, J ANAT, V215, P27, DOI 10.1111/j.1469-7580.2008.00978.x
   Cambonie G, 2007, AM J PHYSIOL-REG I, V292, pR1236, DOI 10.1152/ajpregu.00227.2006
   Caricilli AM, 2008, J ENDOCRINOL, V199, P399, DOI 10.1677/JOE-08-0354
   Cole JE, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/393946
   Curhan GC, 1996, CIRCULATION, V94, P3246, DOI 10.1161/01.CIR.94.12.3246
   Dasu MR, 2010, DIABETES CARE, V33, P861, DOI 10.2337/dc09-1799
   Franco MDP, 2003, CARDIOVASC RES, V59, P767, DOI 10.1016/S0008-6363(03)00461-9
   Fujimaki A, 2011, PLACENTA, V32, P367, DOI 10.1016/j.placenta.2011.02.004
   Gill R, 2010, FREE RADICAL BIO MED, V48, P1121, DOI 10.1016/j.freeradbiomed.2010.01.006
   Giussani DA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031017
   Guo R, 2010, REPROD SCI, V17, P540, DOI 10.1177/1933719110364061
   Hahn-Zoric M, 2002, PEDIATR RES, V51, P201, DOI 10.1203/00006450-200202000-00013
   Harder T, 2007, AM J EPIDEMIOL, V165, P849, DOI 10.1093/aje/kwk071
   Herrera EA, 2012, J PHYSIOL-LONDON, V590, P1825, DOI 10.1113/jphysiol.2011.224576
   HEYBORNE KD, 1992, AM J OBSTET GYNECOL, V167, P920, DOI 10.1016/S0002-9378(12)80012-3
   Hitchler MJ, 2007, FREE RADICAL BIO MED, V43, P1023, DOI 10.1016/j.freeradbiomed.2007.06.027
   Huffaker A, 2006, P NATL ACAD SCI USA, V103, P10098, DOI 10.1073/pnas.0603727103
   Israël A, 2010, CSH PERSPECT BIOL, V2, DOI 10.1101/cshperspect.a000158
   Kawai T, 2010, NAT IMMUNOL, V11, P373, DOI 10.1038/ni.1863
   Leduc L, 2011, EUR J OBSTET GYN R B, V156, P46, DOI 10.1016/j.ejogrb.2011.01.007
   Lemaitre B, 1996, CELL, V86, P973, DOI 10.1016/S0092-8674(00)80172-5
   Lin SC, 2010, NATURE, V465, P885, DOI 10.1038/nature09121
   Lo Vasco VR, 2012, J REPROD IMMUNOL, V93, P64, DOI 10.1016/j.jri.2011.10.001
   Medzhitov R, 2001, NAT REV IMMUNOL, V1, P135, DOI 10.1038/35100529
   Menendez-Castro C, 2012, CLIN SCI, V123, P437, DOI 10.1042/CS20110637
   Mohn A, 2007, J CLIN ENDOCR METAB, V92, P1372, DOI 10.1210/jc.2006-1344
   Polykratis A, 2012, CIRCULATION, V126, P1739, DOI 10.1161/CIRCULATIONAHA.112.100339
   Powers KA, 2006, J EXP MED, V203, P1951, DOI 10.1084/jem.20060943
   Prince LS, 2005, DEV DYNAM, V233, P553, DOI 10.1002/dvdy.20362
   Reyna SM, 2008, DIABETES, V57, P2595, DOI 10.2337/db08-0038
   Rounioja S, 2003, CARDIOVASC RES, V60, P156, DOI 10.1016/S0008-6363(03)00338-9
   Rueda-Clausen CF, 2011, CARDIOVASC RES, V90, P285, DOI 10.1093/cvr/cvq363
   Rueda-Clausen CF, 2011, DIABETES, V60, P507, DOI 10.2337/db10-1239
   Sakkinen PA, 2000, AM J EPIDEMIOL, V152, P897, DOI 10.1093/aje/152.10.897
   Sato S, 2005, NAT IMMUNOL, V6, P1087, DOI 10.1038/ni1255
   Sen S, 2010, DIABETES, V59, P3058, DOI 10.2337/db10-0301
   Shembade N, 2010, SCIENCE, V327, P1135, DOI 10.1126/science.1182364
   Suzuki N, 2002, NATURE, V416, P750, DOI 10.1038/nature736
   Thompson JA, 2011, J PHYSIOL-LONDON, V589, P3319, DOI 10.1113/jphysiol.2011.210625
   Thompson JA, 2011, SEMIN REPROD MED, V29, P211, DOI 10.1055/s-0031-1275522
   Trudinger B, 2002, J SOC GYNECOL INVEST, V9, P152, DOI 10.1016/S1071-5576(02)00147-8
   Yamamoto M, 2003, SCIENCE, V301, P640, DOI 10.1126/science.1087262
   Yan X, 2010, ENDOCRINOLOGY, V151, P380, DOI 10.1210/en.2009-0849
   Yzydorczyk C, 2006, AM J PHYSIOL-REG I, V291, pR1060, DOI 10.1152/ajpregu.00798.2005
NR 50
TC 21
Z9 31
U1 0
U2 14
PU PORTLAND PRESS LTD
PI LONDON
PA CHARLES DARWIN HOUSE, 12 ROGER STREET, LONDON WC1N 2JU, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD JUL
PY 2013
VL 125
IS 1-2
BP 19
EP 25
DI 10.1042/CS20120673
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 154YE
UT WOS:000319711800002
PM 23485061
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sakamuri, A
   Sakamuri, SSVP
   Kona, SR
   Jeyapal, S
   Ibrahim, A
AF Sakamuri, Anil
   Sakamuri, Siva S. V. P.
   Kona, Suryam Reddy
   Jeyapal, Sugeedha
   Ibrahim, Ahamed
TI Diets with low n-6:n-3 PUFA ratio protects rats from fructose-induced
   dyslipidemia and associated hepatic changes: Comparison between 18:3 n-3
   and long-chain n-3 PUFA
SO PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
LA English
DT Article
DE n-6:n-3 pufa ratio; High-fructose diet; Metabolic syndrome;
   Dyslipidemia; Hepatic tissue inflammation; Oxidative stress;
   Alpha-linolenic acid; Long-chain n-3 PUFA
ID POLYUNSATURATED FATTY-ACIDS; 11-BETA-HYDROXYSTEROID DEHYDROGENASE
   TYPE-1; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   PARTIAL REPLACEMENT; BETA-OXIDATION; LINOLEIC-ACID; LIVER; INFLAMMATION
AB In the present study, we investigated the impact of substituting alpha-linolenic acid (ALA) or long-chain n-3 PUFA (eicosapentaenoic acid and docosahexaenoic acid) for linoleic acid and hence decreasing n-6:n-3 PUFA ratio on high-fructose diet-induced hypertriglyceridemia and associated hepatic changes. Weanling male Wistar rats were divided into four groups and fed with starch-diet (n-6:n-3 PUFA ratio 215:1) and high-fructose diets with different n-6:n-3 PUFA ratio (215:1, 2:1 with ALA and 5:1 with long-chain n-3 PUFA) for twenty-four weeks. Substitution of linoleic acid with ALA (n-6:n-3 PUFA ratio of 2) or long-chain n-3 PUFA (n-6:n-3 PUFA ratio of 5) protected the rats from fructose-induced dyslipidemia, hepatic oxidative stress and corrected lipogenic and proinflammatory gene expression. Both ALA and long-chain n-3 PUFA supplementation also reversed the fructose-induced upregulation of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) gene, which is involved in the generation of active glucocorticoids in tissues. Although both ALA and LC n-3 PUFA prevented fructose-induced dyslipidemia to a similar extent, compared to ALA, LC n-3 PUFA is more effective in preventing hepatic oxidative stress and inflammation.
C1 [Sakamuri, Anil; Sakamuri, Siva S. V. P.; Kona, Suryam Reddy; Jeyapal, Sugeedha; Ibrahim, Ahamed] Natl Inst Nutr, Dept Lipid Chem, Hyderabad, India.
   [Sakamuri, Siva S. V. P.] Tulane Univ, Sch Med, Dept Pharmacol, New Orleans, LA 70112 USA.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute of
   Nutrition (NIN); Tulane University
RP Ibrahim, A (corresponding author), Natl Inst Nutr, Dept Lipid Chem, Hyderabad, India.
EM ahamed65@yahoo.co.in
OI Sakamuri, Siva Sankara Vara Prasad/0000-0003-3569-9985
FU Department of Biotechnology, Government of India
   [BT/PR6181/FNS/20/568/2012]; Council of Scientific and Industrial
   Research, Government of India
FX This study was supported by grants in aid (BT/PR6181/FNS/20/568/2012,
   25/02/2013) from the Department of Biotechnology, Government of India,
   to AI. AS was supported by a fellowship from the Council of Scientific
   and Industrial Research, Government of India.
CR [Anonymous], 1984, METHOD ENZYMOL
   Balakumar M, 2016, MOL CELL BIOCHEM, V423, P93, DOI 10.1007/s11010-016-2828-5
   Bantle JP, 2000, AM J CLIN NUTR, V72, P1128
   Berthiaume M, 2007, AM J PHYSIOL-ENDOC M, V293, pE1045, DOI 10.1152/ajpendo.00276.2007
   BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911
   Borén J, 2015, ARTERIOSCL THROM VAS, V35, P2218, DOI 10.1161/ATVBAHA.115.305614
   Bremer AA, 2014, J NUTR, V144, P5, DOI 10.3945/jn.113.178061
   Busserolles J, 2002, EXP BIOL MED, V227, P837, DOI 10.1177/153537020222700918
   Butler AA, 2019, J LIPID RES, V60, P805, DOI 10.1194/jlr.M089508
   Castro MC, 2015, LIFE SCI, V137, P1, DOI 10.1016/j.lfs.2015.07.010
   Crescenzo R, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00411
   Demirtas CY, 2018, BRATISL MED J, V119, P36, DOI 10.4149/BLL_2018_008
   Depner CM, 2013, J NUTR, V143, P315, DOI 10.3945/jn.112.171322
   Dong B, 2013, J LIPID RES, V54, P1241, DOI 10.1194/jlr.M032599
   Faeh D, 2005, DIABETES, V54, P1907, DOI 10.2337/diabetes.54.7.1907
   FLOHE L, 1984, METHOD ENZYMOL, V105, P114
   Galipeau D, 2002, AM J PHYSIOL-HEART C, V283, pH2478, DOI 10.1152/ajpheart.00243.2002
   Gao HQ, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/570948
   Ghafoorunissa, 2005, J NUTR, V135, P2634, DOI 10.1093/jn/135.11.2634
   Grundy SM, 1999, AM J CARDIOL, V83, p25F
   Guo XF, 2017, NUTRIENTS, V9, DOI 10.3390/nu9070703
   Hannou SA, 2018, J CLIN INVEST, V128, P545, DOI 10.1172/JCI96702
   Hermanowski-Vosatka A, 2005, J EXP MED, V202, P517, DOI 10.1084/jem.20050119
   Hirahatake KM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026583
   Ikeda I, 1998, BIOSCI BIOTECH BIOCH, V62, P675, DOI 10.1271/bbb.62.675
   Jensen VS, 2018, DIABETOL METAB SYNDR, V10, DOI 10.1186/s13098-018-0307-8
   Jeyapal S, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-29222-y
   Karise Iara, 2017, Biochim Open, V4, P19, DOI 10.1016/j.biopen.2017.01.002
   Kawasaki T, 2009, J NUTR, V139, P2067, DOI 10.3945/jn.109.105858
   Kazumi T, 1996, DIABETES, V45, P806, DOI 10.2337/diab.45.6.806
   Lavery GG, 2006, J BIOL CHEM, V281, P6546, DOI 10.1074/jbc.M512635200
   Layé S, 2018, PHARMACOL REV, V70, P12, DOI 10.1124/pr.117.014092
   Lazic M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0107658
   Li ZP, 2013, METAB SYNDR RELAT D, V11, P87, DOI 10.1089/met.2012.0090
   Liu HQ, 2013, NUTR RES, V33, P849, DOI 10.1016/j.nutres.2013.07.004
   Liu L, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/6256802
   London E, 2011, OBESITY, V19, P925, DOI 10.1038/oby.2010.284
   Bargut TCL, 2014, LIPIDS, V49, P431, DOI 10.1007/s11745-014-3892-9
   Maithilikarpagaselvi N, 2016, PHARM BIOL, V54, P2857, DOI 10.1080/13880209.2016.1187179
   Marion-Letellier R, 2015, IUBMB LIFE, V67, P659, DOI 10.1002/iub.1428
   Masarone M, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/9547613
   Miyazaki M, 2004, J BIOL CHEM, V279, P25164, DOI 10.1074/jbc.M402781200
   Morgan SA, 2014, P NATL ACAD SCI USA, V111, pE2482, DOI 10.1073/pnas.1323681111
   Muga MA, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-470
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   Oishi K, 2018, J NUTR BIOCHEM, V52, P45, DOI 10.1016/j.jnutbio.2017.09.024
   Paterson JM, 2004, P NATL ACAD SCI USA, V101, P7088, DOI 10.1073/pnas.0305524101
   Patterson S, 2012, ANN ALLERTON CONF, P120, DOI 10.1109/Allerton.2012.6483208
   Saini RK, 2018, LIFE SCI, V203, P255, DOI 10.1016/j.lfs.2018.04.049
   Sakamuri A, 2016, J NUTR METAB, V2016, DOI 10.1155/2016/7510840
   Sakamuri SSVP, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0050216
   Schmitz G, 2008, PROG LIPID RES, V47, P147, DOI 10.1016/j.plipres.2007.12.004
   Scorletti E, 2013, ANNU REV NUTR, V33, P231, DOI 10.1146/annurev-nutr-071812-161230
   Shang TT, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0461-2
   Simopoulos AP, 2008, EXP BIOL MED, V233, P674, DOI 10.3181/0711-MR-311
   Simopoulos AP, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030128
   Stanhope KL, 2012, ANNU REV MED, V63, P329, DOI 10.1146/annurev-med-042010-113026
   Stefan N, 2014, LANCET DIABETES ENDO, V2, P406, DOI 10.1016/S2213-8587(13)70170-0
   Stimson RH, 2013, HORM MOL BIOL CLIN I, V15, P37, DOI 10.1515/hmbci-2013-0015
   Sulis PM, 2017, BIOMED RES INT, V2017, DOI 10.1155/2017/4378328
   Tenenbaum A, 2014, CARDIOVASC DIABETOL, V13, DOI 10.1186/s12933-014-0159-y
   ter Horst KW, 2017, NUTRIENTS, V9, DOI 10.3390/nu9090981
   Tian Y, 2016, BIOMED RES INT, V2016, DOI 10.1155/2016/9462571
   Torres-Castillo N, 2018, OBESITY FACTS, V11, P344, DOI 10.1159/000492116
   Tyagi A, 2014, PROSTAG LEUKOTR ESS, V91, P289, DOI 10.1016/j.plefa.2014.09.003
   Tyagi A, 2012, BRIT J NUTR, V108, P1612, DOI 10.1017/S0007114511007197
   Valenzuela R, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046400
   Vasiljevic A, 2014, EUR J NUTR, V53, P1393, DOI 10.1007/s00394-013-0641-4
   Velickovic N, 2019, EUR J NUTR, V58, P1829, DOI 10.1007/s00394-018-1730-1
   Vos Miriam B, 2008, Medscape J Med, V10, P160
   Wang Y, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/581469
   Wiktorowska-Owczarek A, 2015, ADV CLIN EXP MED, V24, P931, DOI 10.17219/acem/31243
   Yuan FH, 2016, LIPIDS HEALTH DIS, V15, DOI 10.1186/s12944-016-0190-y
   Zhang C, 2012, TOXICOL LETT, V212, P229, DOI 10.1016/j.toxlet.2012.06.002
NR 74
TC 5
Z9 6
U1 0
U2 14
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0952-3278
EI 1532-2823
J9 PROSTAG LEUKOTR ESS
JI Prostaglandins Leukot. Essent. Fatty Acids
PD APR
PY 2020
VL 155
AR 102082
DI 10.1016/j.plefa.2020.102082
PG 11
WC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
GA LC4TS
UT WOS:000525319100005
PM 32169807
DA 2025-06-11
ER

PT J
AU Poudel, A
   Zhou, JY
   Mekala, N
   Welchko, R
   Rosca, MG
   Li, LX
AF Poudel, Anil
   Zhou, Joseph Yi
   Mekala, Naveen
   Welchko, Ryan
   Rosca, Mariana Georgeta
   Li, Lixin
TI Berberine hydrochloride protects against cytokine-induced inflammation
   through multiple pathways in undifferentiated C2C12 myoblast cells
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE berberine; cytokine; insulin resistance; inflammation
ID INDUCED INSULIN-RESISTANCE; KAPPA-B ACTIVATION; SKELETAL-MUSCLE;
   OXIDATIVE STRESS; KINASE; MECHANISM; DYSFUNCTION; EXPRESSION; INDUCTION;
   OBESITY
AB Obesity is associated with skeletal muscle insulin resistance and the development of metabolic syndrome. Undifferentiated skeletal muscle cells are sensitive to oxidative stress. Berberine hydrochloride (BBR) improves insulin resistance and exhibits anti-inflammatory properties. However, the underlying mechanism and the cell signaling pathways involved remain largely elusive. We therefore investigated the anti-inflammatory effects of BBR and the signaling pathways using skeletal C2C12 myoblast cells. Undifferentiated C2C12 myoblast cells were treated with interleukin-1 beta alone or in combination with tumor necrosis factor-alpha in the presence or absence of BBR. We found that BBR reduced the cytokine-induced expression of inducible nitric oxide synthase and stress-related kinases including p-38 mitogen-activated protein kinase, nuclear factor kappa B (NF-kappa B), and stress-activated protein kinases/Jun amino-terminal kinases (SAPK/JNK) in C2C12 myoblast cells. Furthermore, BBR reversed cytokine-mediated suppression of AMP-activated protein kinase (AMPK alpha), sirtuin-1 (SIRT-1), and PPAR-gamma coactivator-1 alpha (PGC-1 alpha). In addition, cytokine-induced reduction of mitochondrial marker proteins and function were rescued after BBR treatment. Catalase, an antioxidant enzyme, was elevated after BBR treatment. Our results demonstrate that BBR ameliorates cytokine-induced inflammation. The anti-inflammatory effect of BBR in skeletal progenitor cells is mediated through pathways including activation of the AMPK alpha-SIRT-1-PGC-1 alpha, inhibition of the mitogen-activated protein kinase 4 (MKK4)-SAPK/JNK-C-JUN, as well as protection of mitochondrial bioenergetics. BBR may be a potential medication for metabolic syndrome.
C1 [Poudel, Anil; Welchko, Ryan; Li, Lixin] Cent Michigan Univ, Phys Assistant Program, Coll Hlth Profess, Mt Pleasant, MI 48859 USA.
   [Zhou, Joseph Yi; Mekala, Naveen; Rosca, Mariana Georgeta] Cent Michigan Univ, Coll Med, Mt Pleasant, MI 48859 USA.
C3 Central Michigan University; Central Michigan University
RP Li, LX (corresponding author), Cent Michigan Univ, Phys Assistant Program, Coll Hlth Profess, Mt Pleasant, MI 48859 USA.
EM li6l@cmich.edu
RI LI, LIXIN/KFS-0074-2024; Rosca, Mariana/ABH-7847-2020; Mekala,
   Naveen/AGN-0107-2022
OI Rosca, Mariana/0000-0003-3605-9787
FU Central Michigan University
FX L.L. is supported by the faculty start-up fund from Central Michigan
   University. The authors thank Darren Story for editing of English
   grammar for the paper and Cassandra Ann Keinath for technical support.
CR Adams V, 2002, CARDIOVASC RES, V54, P95, DOI 10.1016/S0008-6363(02)00228-6
   BEG AA, 1993, MOL CELL BIOL, V13, P3301, DOI 10.1128/MCB.13.6.3301
   Berdichevsky A, 2010, J BIOL CHEM, V285, P21581, DOI 10.1074/jbc.M109.093633
   Brown AE, 2015, AM J PHYSIOL-ENDOC M, V308, pE63, DOI 10.1152/ajpendo.00115.2014
   Brozzi F, 2015, DIABETOLOGIA, V58, P2307, DOI 10.1007/s00125-015-3669-6
   Brusq JM, 2006, J LIPID RES, V47, P1281, DOI 10.1194/jlr.M600020-JLR200
   Cao HM, 2014, J ENDOCRINOL, V220, pT47, DOI 10.1530/JOE-13-0339
   Chen Fei, 2002, Current Drug Targets - Inflammation and Allergy, V1, P137, DOI 10.2174/1568010023344706
   Choi YH, 2016, DRUG DEVELOP RES, V77, P310, DOI 10.1002/ddr.21325
   Correia JC, 2015, TRENDS ENDOCRIN MET, V26, P305, DOI 10.1016/j.tem.2015.03.010
   Coste A, 2008, P NATL ACAD SCI USA, V105, P17187, DOI 10.1073/pnas.0808207105
   Cui GL, 2009, J BIOL CHEM, V284, P28420, DOI 10.1074/jbc.M109.012674
   Doerrier C, 2018, METHODS MOL BIOL, V1782, P31, DOI 10.1007/978-1-4939-7831-1_3
   Gomes AP, 2012, BBA-MOL BASIS DIS, V1822, P185, DOI 10.1016/j.bbadis.2011.10.008
   Green CJ, 2011, DIABETES, V60, P2810, DOI 10.2337/db11-0263
   Grzelkowska-Kowalczyk K, 2006, POL J VET SCI, V9, P1
   Guo T, 2016, SCI REP-UK, V6, DOI 10.1038/srep22612
   Hao XH, 2012, INFLAMMATION, V35, P841, DOI 10.1007/s10753-011-9385-6
   Henstridge DC, 2012, DIABETOLOGIA, V55, P2769, DOI 10.1007/s00125-012-2652-8
   Jeong HW, 2009, AM J PHYSIOL-ENDOC M, V296, pE955, DOI 10.1152/ajpendo.90599.2008
   Kim J, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0058292
   Lee YS, 2006, DIABETES, V55, P2256, DOI 10.2337/db06-0006
   Li ZG, 2014, J APPL MATH, DOI 10.1155/2014/807265
   Lou TJ, 2011, INFLAMMATION, V34, P659, DOI 10.1007/s10753-010-9276-2
   Lu DY, 2010, J CELL BIOCHEM, V110, P697, DOI 10.1002/jcb.22580
   Martins AR, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-30
   Pang B, 2015, INT J ENDOCRINOL, V2015, DOI 10.1155/2015/905749
   Patková J, 2014, CELL PHYSIOL BIOCHEM, V33, P1439, DOI 10.1159/000358709
   Petersen KF, 2007, P NATL ACAD SCI USA, V104, P12587, DOI 10.1073/pnas.0705408104
   Pilon G, 2004, J BIOL CHEM, V279, P20767, DOI 10.1074/jbc.M401390200
   Remels AHV, 2013, BBA-MOL BASIS DIS, V1832, P1313, DOI 10.1016/j.bbadis.2013.03.018
   Salminen A, 2011, J MOL MED, V89, P667, DOI 10.1007/s00109-011-0748-0
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Sprague AH, 2009, BIOCHEM PHARMACOL, V78, P539, DOI 10.1016/j.bcp.2009.04.029
   Sprowles A, 2005, EXP CELL RES, V308, P459, DOI 10.1016/j.yexcr.2005.05.010
   Tan CK, 2012, NUTR DIABETES, V2, DOI 10.1038/nutd.2012.1
   Tournier C, 2001, GENE DEV, V15, P1419, DOI 10.1101/gad.888501
   Verma G, 2010, APOPTOSIS, V15, P864, DOI 10.1007/s10495-010-0498-4
   Xu M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0103702
   Yang HH, 2012, SCI WORLD J, P1, DOI 10.1100/2012/149132
   Ye F, 2013, ANAL BIOCHEM, V437, P52, DOI 10.1016/j.ab.2013.02.010
   Yin J, 2008, AM J PHYSIOL-ENDOC M, V294, pE148, DOI 10.1152/ajpendo.00211.2007
   Yu XX, 2000, AM J PHYSIOL-ENDOC M, V279, pE433, DOI 10.1152/ajpendo.2000.279.2.E433
   Yuan MS, 2001, SCIENCE, V293, P1673, DOI 10.1126/science.1061620
   Zarubin T, 2005, CELL RES, V15, P11, DOI 10.1038/sj.cr.7290257
   Zhang BB, 2009, CELL METAB, V9, P407, DOI 10.1016/j.cmet.2009.03.012
   Zhang HP, 2017, INT CRIT THOUGHT, V7, P93, DOI 10.1080/21598282.2017.1288362
   Zhang JW, 2010, ENDOCRINE, V37, P157, DOI 10.1007/s12020-009-9283-y
   Zhang ZG, 2016, SCI REP-UK, V6, DOI 10.1038/srep20848
   Zheng DH, 2001, J APPL PHYSIOL, V91, P1073, DOI 10.1152/jappl.2001.91.3.1073
   Zhou JY, 2008, BIOL PHARM BULL, V31, P1169, DOI 10.1248/bpb.31.1169
   Zhou Ji-yin, 2007, Yaoxue Xuebao, V42, P1243
   Zhou LB, 2007, METABOLISM, V56, P405, DOI 10.1016/j.metabol.2006.10.025
NR 53
TC 12
Z9 15
U1 1
U2 13
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD AUG
PY 2019
VL 97
IS 8
BP 699
EP 707
DI 10.1139/cjpp-2018-0653
PG 9
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA IL9OG
UT WOS:000477613400002
PM 31026403
DA 2025-06-11
ER

PT J
AU Dong, SF
   Yasui, N
   Negishi, H
   Kishimoto, A
   Sun, JN
   Ikeda, K
AF Dong, Shi-fen
   Yasui, Naomi
   Negishi, Hiroko
   Kishimoto, Aya
   Sun, Jian-ning
   Ikeda, Katsumi
TI Increased Oxidative Stress in Cultured 3T3-L1 Cells was Attenuated by
   Berberine Treatment
SO NATURAL PRODUCT COMMUNICATIONS
LA English
DT Article
DE Berberine; 3T3-L1 cells; Oxidative stress
ID METABOLIC SYNDROME; DIFFERENTIATION; EXPRESSION; ADIPOCYTE; OBESITY;
   INSULIN
AB The 3T3-L1 cell line is one of the most well-characterized and reliable models for studying adipocytes. Increased oxidative stress in accumulated fat was found in 3T3-L1 cells. Berberine, an isoquinoline alkaloid, could suppress fat deposition in 3T3-L1 cells; however, whether berberine suppresses increased oxidative stress is not well known. In this study, we observed the effect of berberine on increased oxidative stress in 3T3-L1 cells. 3T3-L1 cells were cultured and treated with berberine (5-20 mu M) from day 3 to day 8. We confirmed that berberine markedly inhibited fat accumulation and lipid droplets in 3T3-L1 adipocytes and decreased triglyceride content Berberine inhibited increased oxidative stress in 3T3-L1 cells by suppressing reactive oxygen species (ROS) production, and increased glutathione peroxidase (GPx) gene expression and GPx activity. Berberine also markedly reduced adipokines secreted by adipocytes, including leptin and resistin.
C1 [Dong, Shi-fen; Sun, Jian-ning] Beijing Univ Chinese Med, Sch Chinese Mat Med, Dept Pharmacol, Beijing 100029, Peoples R China.
   [Yasui, Naomi; Negishi, Hiroko; Kishimoto, Aya; Ikeda, Katsumi] Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan.
C3 Beijing University of Chinese Medicine; Mukogawa Women's University
RP Dong, SF (corresponding author), Beijing Univ Chinese Med, Sch Chinese Mat Med, Dept Pharmacol, Beijing 100029, Peoples R China.
EM ikeda@mukogawa-u.ac.jp
RI Dong, Shifen/AAS-9769-2021
CR Choi BH, 2006, EXP MOL MED, V38, P599, DOI 10.1038/emm.2006.71
   Cicero AF, 2014, CURR VASC PHARMACOL, V12, P565, DOI 10.2174/15701611113119990120
   D'Apolito M, 2010, J CLIN INVEST, V120, P203, DOI 10.1172/JCI37672
   Dong SF, 2011, EUR J PHARMACOL, V660, P368, DOI 10.1016/j.ejphar.2011.03.024
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   GREEN H, 1974, CELL, V1, P113, DOI 10.1016/0092-8674(74)90126-3
   Habtemariam S, 2011, NAT PROD COMMUN, V6, P1089
   Haugen F, 2001, FEBS LETT, V507, P105, DOI 10.1016/S0014-5793(01)02968-4
   Huang C, 2006, BIOCHEM BIOPH RES CO, V348, P571, DOI 10.1016/j.bbrc.2006.07.095
   IKRAM M, 1975, PLANTA MED, V28, P353, DOI 10.1055/s-0028-1097869
   Kobayashi H, 2009, AM J PHYSIOL-ENDOC M, V296, pE1326, DOI 10.1152/ajpendo.90921.2008
   Liu F, 2006, CHINESE MED J-PEKING, V119, P496, DOI 10.1097/00029330-200603020-00011
   Pérez-Rubio KG, 2013, METAB SYNDR RELAT D, V11, P366, DOI 10.1089/met.2012.0183
   Steppan CM, 2001, NATURE, V409, P307, DOI 10.1038/35053000
NR 14
TC 15
Z9 17
U1 0
U2 12
PU NATURAL PRODUCTS INC
PI WESTERVILLE
PA 7963 ANDERSON PARK LN, WESTERVILLE, OH 43081 USA
SN 1934-578X
EI 1555-9475
J9 NAT PROD COMMUN
JI Nat. Prod. Commun.
PD JUN
PY 2015
VL 10
IS 6
BP 895
EP 897
PG 3
WC Chemistry, Medicinal; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology
GA CK9NB
UT WOS:000356565700024
PM 26197511
DA 2025-06-11
ER

PT J
AU Walker, L
   Smith, N
   Delon, C
AF Walker, Louise
   Smith, Natalie
   Delon, Christine
TI Weight loss, hypertension and mental well-being improvements during
   COVID-19 with a multicomponent health promotion programme on Zoom: a
   service evaluation in primary care
SO BMJ NUTRITION, PREVENTION & HEALTH
LA English
DT Article
DE weight management; blood pressure lowering; dietary patterns; mental
   health; metabolic syndrome
ID LOW-CARBOHYDRATE-DIET; MANAGEMENT; ADULTS; APPETITE; INSULIN; STRESS;
   IMPACT; SLEEP; TIME
AB BackgroundObesity is a risk factor for complications from SARS-CoV-2 infection, increasing the need for effective weight management measures in primary care. However, in the UK, COVID-19 restrictions have hampered primary care weight management referral and delivery, and COVID-19 related weight gain has been reported. The present study evaluated outcomes from a multicomponent weight loss and health promotion programme in UK primary care, delivered remotely due to COVID-19 restrictions.MethodPatients with obesity, type 2 diabetes or pre-diabetes attended six 90 min sessions over 10 weeks on Zoom. The dietary component comprised a low-carbohydrate 'real food' approach, augmented with education on physical activity, intermittent fasting, gut health, stress management, sleep and behaviour change. Anthropometric and cardiometabolic data were self-reported. Mental well-being was assessed with the Warwick Edinburgh Mental Wellbeing Scale. Subjective outcomes and participant feedback about the programme were collected with an anonymous online survey.ResultsTwenty participants completed the programme. Weight loss and improvements in body mass index, waist circumference, systolic and diastolic blood pressure and mental well-being achieved statistical and clinical significance. Mean weight loss (5.8 kg) represented a 6.5% weight loss. Participants' subjective outcomes included weight loss without hunger (67%) and increased confidence in their ability to improve health (83%). All participants reported the usage of Zoom to access the programme as acceptable with 83% reporting it worked well.ConclusionA multicomponent weight loss and health promotion programme with a low-carbohydrate dietary component, clinically and statistically significantly improved health outcomes including weight status, blood pressure and mental well-being in a group of primary care patients when delivered remotely. Further research is warranted.
C1 [Walker, Louise; Smith, Natalie] Bentley Village Surg, Farnham GU10 5LP, England.
RP Walker, L (corresponding author), Bentley Village Surg, Farnham GU10 5LP, England.
EM lou@louwalker.com
OI Delon, Christine/0000-0001-5163-1716
FU A31 Group Primary Care Network
FX The authors would like to thank the participating patients, and staff
   and partners of the A31 Group Primary Care Network. We are grateful to
   Dr Campbell Murdoch, Dr Jen Unwin and Dr David Unwin for reviewing
   drafts of the manuscript, and to Sam Feltham for his help throughout the
   project. Finally, our thanks go to the Public Health Collaboration
   ambassadors who facilitated the group sessions and online support
   groups.
CR Accurso A, 2008, NUTR METAB, V5, DOI 10.1186/1743-7075-5-9
   Adam-Perrot A, 2006, OBES REV, V7, P49, DOI 10.1111/j.1467-789X.2006.00222.x
   Ahern AL, 2017, LANCET, V389, P2214, DOI 10.1016/S0140-6736(17)30647-5
   Ahmed SR, 2020, BMJ OPEN DIAB RES CA, V8, DOI 10.1136/bmjdrc-2019-000980
   Allington D., 2020, Getting used to life under lockdown? coronavirus in the UK
   [Anonymous], 2016, Government Dietary Recommendations Government recommendations for energy and nutrients for males and females aged 1-18 years and 19+ years Internet
   Athinarayanan SJ, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00348
   Berk M, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-200
   Blüher M, 2019, NAT REV ENDOCRINOL, V15, P288, DOI 10.1038/s41574-019-0176-8
   Brands MW, 2012, AM J PHYSIOL-REG I, V303, pR1101, DOI 10.1152/ajpregu.00390.2012
   British Dietetic Association, 2018, BDA policy statement: low carbohydrate diets for the management of type 2 diabetes in adults
   Choi YJ, 2020, NUTRIENTS, V12, DOI 10.3390/nu12072005
   Covid Symptom Study, 2020, Has lockdown influenced our eating habits? the silent pandemic: how lockdown is affecting our future health
   Davies MJ, 2018, DIABETOLOGIA, V61, P2461, DOI [10.1007/s00125-018-4729-5, 10.2337/dci18-0033]
   Deakin T, 2005, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003417.pub2
   Diabetes Australia, 2018, Position statement: Low carbohydrate eating for people with diabetes
   Diabetes UK, 2017, Position statement: low-carb diets for people with diabetes
   Donaghy E, 2019, BRIT J GEN PRACT, V69, pE586, DOI 10.3399/bjgp19X704141
   Elder CR, 2012, INT J OBESITY, V36, P86, DOI 10.1038/ijo.2011.60
   Evert AB, 2019, DIABETES CARE, V42, P731, DOI 10.2337/dci19-0014
   Feinman RD, 2015, NUTRITION, V31, P1, DOI 10.1016/j.nut.2014.06.011
   [Anonymous], 2020, BMJ, V371, pm4269, DOI [10.1136/bmj.m2382, 10.1136/bmj.m4269]
   Firth J, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00350
   Geiker NRW, 2018, OBES REV, V19, P81, DOI 10.1111/obr.12603
   Harsha DW, 2008, HYPERTENSION, V51, P1420, DOI 10.1161/HYPERTENSIONAHA.107.094011
   Hartmann-Boyce J, 2014, OBES REV, V15, P920, DOI 10.1111/obr.12220
   Hoddy KK, 2020, OBESITY, V28, pS29, DOI 10.1002/oby.22829
   Hu T, 2016, NUTR METAB CARDIOVAS, V26, P476, DOI 10.1016/j.numecd.2015.11.011
   Huntriss R, 2018, EUR J CLIN NUTR, V72, DOI 10.1038/s41430-017-0019-4
   Idris Iskandar, 2020, JMIR Diabetes, V5, pe15189, DOI 10.2196/15189
   Jacka FN, 2017, BMC MED, V15, DOI 10.1186/s12916-017-0791-y
   Jolly K, 2011, BMJ-BRIT MED J, V343, DOI 10.1136/bmj.d6500
   Jones Tania, 2019, Future Healthc J, V6, P8, DOI 10.7861/futurehosp.6-1-8
   Kelly T, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17072557
   Lean MEJ, 2018, LANCET, V391, P541, DOI 10.1016/S0140-6736(17)33102-1
   Loef M, 2012, PREV MED, V55, P163, DOI 10.1016/j.ypmed.2012.06.017
   Ludwig DS, 2018, JAMA INTERN MED, V178, P1098, DOI 10.1001/jamainternmed.2018.2933
   Maheswaran H, 2012, HEALTH QUAL LIFE OUT, V10, DOI 10.1186/1477-7525-10-156
   Martin CK, 2011, OBESITY, V19, P1963, DOI 10.1038/oby.2011.62
   MHCLG, 2019, English Indices of Deprivation 2019: Mapping Resources
   Morris E, 2020, DIABETES OBES METAB, V22, P512, DOI 10.1111/dom.13915
   Mullens A., 2020, Ketogenic diet for mental health: come for the weight loss, stay for the mental health benefits?
   Murdoch C, 2019, BRIT J GEN PRACT, V69, P360, DOI 10.3399/bjgp19X704525
   Náfrádi L, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0186458
   National Health Service, Nhs APP. secondary NHS APP
   National Institute for Clinical and Care Excellence, 2014, Clinical guideline [CG189]
   National Institute for Clinical and Care Excellence, 2014, Clinical guideline
   National Institute for Clinical and Care Excellence, 2014, Public health guideline [PH53]
   National Institute for Clinical and Care Excellence, 2015, NICE guideline (NG28)
   NHS, Gp online consultations 2020
   NHS Digital, 2020, Hospital admitted patient care activity 201920
   O'Connor RC, 2021, BRIT J PSYCHIAT, V218, P326, DOI 10.1192/bjp.2020.212
   Public Health England, 2020, Excess Weight and COVID-19
   QuinonesGalvan A, 1997, J NEPHROL, V10, P188
   Russell-Westhead M, 2020, RHEUMATOL ADV PRACT, V4, DOI 10.1093/rap/rkaa003
   Sackner-Bernstein J, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0139817
   Saslow Laura R, 2018, JMIR Diabetes, V3, pe12, DOI 10.2196/diabetes.9333
   Sattar N, 2020, CIRCULATION, V142, P4, DOI 10.1161/CIRCULATIONAHA.120.047659
   Sheeran P, 2016, HEALTH PSYCHOL, V35, P1178, DOI 10.1037/hea0000387
   Slimming World, 2020, Slimming World's Lockdown Commitment. Secondary Slimming World's Lockdown Commitment
   Tennant R, 2007, HEALTH QUAL LIFE OUT, V5, DOI 10.1186/1477-7525-5-63
   The Public Health Collaboration, 2020, Public Health Collaboration Ambassador & Healthcare Professionals Case Study Book
   Unwin D, 2020, BMJ NUTR PREV HLTH, V3, P285, DOI 10.1136/bmjnph-2020-000072
   Unwin D, 2014, PRACT DIABETES, V31, P76, DOI 10.1002/pdi.1835
   Unwin DJ, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16152680
   Weight Watchers, 2020, IMP WORKSH UPD SEC I
NR 66
TC 6
Z9 6
U1 0
U2 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
EI 2516-5542
J9 BMJ NUTR PREV HLTH
JI BMJ Nutr. Prev. Health
PD JUN
PY 2021
VL 4
IS 1
BP 102
EP 110
DI 10.1136/bmjnph-2020-000219
PG 9
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA CH5Z1
UT WOS:001124388600032
PM 34308117
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zheng, L
   Cui, CC
   Yue, SQ
   Yan, H
   Zhang, T
   Ding, M
   Sun, QC
   He, CY
   Ren, H
AF Zheng, Lan
   Cui, Cancan
   Yue, Siqi
   Yan, Han
   Zhang, Te
   Ding, Meng
   Sun, Qichao
   He, Chengyan
   Ren, Hui
TI Longitudinal association between triglyceride glucose index and
   depression progression in middle-aged and elder adults: A national
   retrospective cohort study
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Triglyceride glucose index; Insulin resistance; Depression; Cohort study
ID INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   ADIPOSE-TISSUE; RISK-FACTORS; POPULATION; PREVALENCE; OBESITY;
   ATHEROSCLEROSIS; OVERWEIGHT
AB Background and aims: Psychological symptoms are prevalent among individuals with non-communicable diseases, while the longitudinal association between triglyceride glucose (TyG) index, an indicator of metabolic health, and depression progression remains unclear yet. This study aims to investigate the association of baseline TyG index and depression progression in middle-aged and elder adults. Methods and results: This retrospective cohort study enrolled 8287 participants aged 45 years or above from national China Health and Retirement Longitudinal Study in visit 1 (2011-2012), which were biennially followed for depression score until visit 4 (2017-2018). Multivariateadjusted regression models were used to evaluate the association of baseline TyG index with the individual level change rate and slope of depression score. The mean age (+/- SD) of participants was 58.25 +/- 9.10 years, and 3806 (45.9%) were men. There was no significant difference of depression score at baseline across TyG quartile groups (P Z 0.228). Participants in the highest quartile of TyG index had a 0.124 (95% CI: 0.018-0.230) higher change rate of depression score, and a 0.127 (95% CI: 0.019-0.235) higher change slope, compared to those in the lowest. The observed associations were consistent in multiple sensitivity analyses, and stable in men, the elder, and overweight people. Conclusion: TyG index is positively associated with depression progression especially in men, the elder and overweight people, which provides new insights for the primary prevention of depression disorder. (c) 2022 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
C1 [Zheng, Lan; Cui, Cancan; Yue, Siqi; He, Chengyan] Jilin Univ, China Japan Union Hosp, Dept Lab Med, Changchun, Peoples R China.
   [Zheng, Lan] Jilin Univ, Hosp Stomatol, Dept Lab Med, Changchun, Peoples R China.
   [Yan, Han] Jilin Univ, China Japan Union Hosp, Dept Endocrinol & Metab, Changchun, Peoples R China.
   [Zhang, Te] Jilin Univ, China Japan Union Hosp, Dept Anesthesiol, Changchun, Peoples R China.
   [Ding, Meng] Jilin Univ, China Japan Union Hosp, Endoscopy Ctr, Changchun, Peoples R China.
   [Sun, Qichao] Jilin Univ, China Japan Union Hosp, Imaging & Nucl Med, Changchun, Peoples R China.
   [Ren, Hui] Jilin Univ, China Japan Union Hosp, Dept Gen Surg, Changchun, Peoples R China.
   [He, Chengyan] Jilin Univ, China Japan Union Hosp, Dept Lab Med, Changchun 130000, Peoples R China.
   [Ren, Hui] Jilin Univ, China Japan Union Hosp, Dept Gen Surg, Changchun 130000, Peoples R China.
C3 Jilin University; Jilin University; Jilin University; Jilin University;
   Jilin University; Jilin University; Jilin University; Jilin University;
   Jilin University
RP He, CY (corresponding author), Jilin Univ, China Japan Union Hosp, Dept Lab Med, Changchun 130000, Peoples R China.; Ren, H (corresponding author), Jilin Univ, China Japan Union Hosp, Dept Gen Surg, Changchun 130000, Peoples R China.
EM lanzheng@jlu.edu.cn; cccui19@mails.jlu.edu.cn; yuesq21@mails.jlu.edu.cn;
   yanhan@jlu.edu.cn; zhangte19@mails.jlu.edu.cn; dingmeng@jlu.edu.cn;
   sunqc18@mails.jlu.edu.cn; lanzheng@jlu.edu.cn; hren@jlu.edu.cn
RI Cui, Cancan/HNC-4267-2023
FU National Institute on Aging (NIA); World Bank; National Natural Science
   Foundation of China
FX This current study uses data from the CHARLS dataset and Codebook. The
   development of the CHARLS was funded by the National Institute on Aging
   (NIA), World Bank and National Natural Science Foundation of China. We
   are grateful for the staff of CHARLS and all the participants.
CR Alexapoulos GS, 2005, LANCET, V365, P1961, DOI 10.1016/S0140-6736(05)66665-2
   Barzegar N, 2020, CARDIOVASC DIABETOL, V19, DOI 10.1186/s12933-020-01121-5
   Black CN, 2015, PSYCHONEUROENDOCRINO, V51, P164, DOI 10.1016/j.psyneuen.2014.09.025
   Blázquez E, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00161
   Cao C, 2020, J AFFECT DISORDERS, V269, P51, DOI 10.1016/j.jad.2020.03.031
   Clarke DM, 2007, AUST J RURAL HEALTH, V15, P148, DOI 10.1111/j.1440-1584.2007.00867.x
   Du TT, 2014, CARDIOVASC DIABETOL, V13, DOI 10.1186/s12933-014-0146-3
   Fernández-Bergés D, 2011, GAC SANIT, V25, P519, DOI 10.1016/j.gaceta.2011.05.009
   Giannini C, 2011, DIABETES CARE, V34, P1869, DOI 10.2337/dc10-2234
   Giovannini S, 2019, J AM MED DIR ASSOC, V20, P564, DOI 10.1016/j.jamda.2019.01.128
   Goldstein BI, 2015, CIRCULATION, V132, P965, DOI 10.1161/CIR.0000000000000229
   Guerrero-Romero F, 2016, ARCH MED RES, V47, P382, DOI 10.1016/j.arcmed.2016.08.012
   Guerrero-Romero F, 2010, J CLIN ENDOCR METAB, V95, P3347, DOI 10.1210/jc.2010-0288
   Hare DL, 2014, EUR HEART J, V35, P1365, DOI 10.1093/eurheartj/eht462
   Hong S, 2021, ALZHEIMERS RES THER, V13, DOI 10.1186/s13195-020-00758-4
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Jung SJ, 2017, BRIT J PSYCHIAT, V211, P14, DOI 10.1192/bjp.bp.116.186726
   Knowler William C, 2002, N Engl J Med, V346, P393, DOI 10.1056/NEJMoa012512
   Laudisio A, 2020, ARCH GERONTOL GERIAT, V89
   Laudisio A, 2018, INT PSYCHOGERIATR, V30, P153, DOI 10.1017/S1041610217001715
   LEMIEUX S, 1993, AM J CLIN NUTR, V58, P463, DOI 10.1093/ajcn/58.4.463
   Levey AS, 2009, ANN INTERN MED, V150, P604, DOI 10.7326/0003-4819-150-9-200905050-00006
   Li SS, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-43776-5
   Liu JK, 2010, J CLIN ENDOCR METAB, V95, P5419, DOI 10.1210/jc.2010-1378
   Liu XC, 2021, FRONT CARDIOVASC MED, V7, DOI 10.3389/fcvm.2020.628109
   Liu XH, 2021, J AFFECT DISORDERS, V282, P1278, DOI 10.1016/j.jad.2021.01.040
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Mannan M, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0157240
   Mannan M, 2016, ASIAN J PSYCHIATR, V21, P51, DOI 10.1016/j.ajp.2015.12.008
   Meng RW, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2019.21043
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Miller AH, 2016, NAT REV IMMUNOL, V16, P22, DOI 10.1038/nri.2015.5
   Onder G, 2018, AGING CLIN EXP RES, V30, P1015, DOI 10.1007/s40520-018-0893-1
   Park B, 2021, TRANSL RES, V228, P42, DOI 10.1016/j.trsl.2020.08.003
   Park C, 2018, BEHAV BRAIN RES, V353, P154, DOI 10.1016/j.bbr.2018.07.011
   Park LT, 2019, NEW ENGL J MED, V380, P559, DOI 10.1056/NEJMcp1712493
   Pereira-Miranda E, 2017, J AM COLL NUTR, V36, P223, DOI 10.1080/07315724.2016.1261053
   Pfaff JJ, 2009, MED J AUSTRALIA, V190, pS75, DOI 10.5694/j.1326-5377.2009.tb02475.x
   Sachdeva AK, 2019, CLIN NUTR, V38, P1447, DOI 10.1016/j.clnu.2018.06.966
   Salk RH, 2017, PSYCHOL BULL, V143, P783, DOI 10.1037/bul0000102
   Shi YY, 2021, BMC PSYCHIATRY, V21, DOI 10.1186/s12888-021-03275-2
   Shin KA, 2019, DIABETES METAB SYNDR, V12, P2251, DOI 10.2147/DMSO.S217628
   Si SC, 2021, FRONT CARDIOVASC MED, V7, DOI 10.3389/fcvm.2020.583473
   Sripetchwandee J, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00496
   Talbot K, 2012, J CLIN INVEST, V122, P1316, DOI 10.1172/JCI59903
   Tang BW, 2020, DIABETOLOGIA, V63, P1305, DOI 10.1007/s00125-020-05131-6
   Vos T, 2016, LANCET, V388, P1545, DOI 10.1016/s0140-6736(16)31678-6
   Wang AX, 2021, CARDIOVASC DIABETOL, V20, DOI 10.1186/s12933-021-01305-7
   Wu ZY, 2022, DIABETES RES CLIN PR, V191, DOI 10.1016/j.diabres.2022.110079
   Wu ZY, 2021, CARDIOVASC DIABETOL, V20, DOI 10.1186/s12933-021-01330-6
   Wu ZY, 2021, NUTR METAB CARDIOVAS, V31, P2042, DOI 10.1016/j.numecd.2021.03.027
   Yaribeygi H, 2019, J CELL PHYSIOL, V234, P8152, DOI 10.1002/jcp.27603
   Zhang M, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-017-0514-x
   Zheng RJ, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0562-y
   Zhou BF, 2002, BIOMED ENVIRON SCI, V15, P83
   Zhou MG, 2019, LANCET, V394, P1145, DOI 10.1016/S0140-6736(19)30427-1
NR 56
TC 16
Z9 17
U1 10
U2 28
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD MAR
PY 2023
VL 33
IS 3
BP 507
EP 515
DI 10.1016/j.numecd.2022.11.015
EA FEB 2023
PG 9
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA G6LT7
UT WOS:000990257600001
PM 36642610
OA Bronze
DA 2025-06-11
ER

PT J
AU Dai, MY
   Zhang, YY
   Chen, Y
   Wang, L
   Tian, YH
AF Dai, Mengyao
   Zhang, Yuyang
   Chen, Yang
   Wang, Long
   Tian, Yanghua
TI The association between lipid accumulation products and depression in US
   adults: A cross-sectional study from NHANES 2005-2018
SO INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE
LA English
DT Article
DE depression; insulin resistance; lipid accumulation product; National
   Health and Nutrition Examination Survey; patient health questionnaire-9
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; ABDOMINAL OBESITY; DISORDERS;
   POPULATION; MECHANISMS; ADIPOSITY; INDEX
AB Objective To investigate the potential correlation between lipid accumulation products (LAP) and depression in adults in the United States.Methods We analyzed data from 13,051 participants from the NHANES 2005-2018 cycle. The LAP index was calculated using the waist circumference (WC) and serum triglyceride (TG) levels, which reflect lipid toxicity. Participants who scored >= 10 on the patient health questionnaire-9 (PHQ-9) were considered depressed. Multivariate logistic regression analyses were conducted to explore the association between the LAP index and depression. Furthermore, we conducted subgroup analysis to identify potentially sensitive populations. Smoothed curve fitting and generalized additive model (GAM) regression were performed to verify the association between the LAP index and depression.Results A total of 13,051 participants were eligible for analysis. After adjusting for all potential confounders, the risk of depression tended to increase with an increasing LAP index (odds ratio [OR]: 1.0011, 95% confidence interval [CI]: 1.0001, 1.0021). Compared to participants with LAP quartile 1, participants with LAP quartile 3 exhibited the highest risk of depression (OR: 1.43, 95%CI: 1.03, 1.99). Subgroup analysis demonstrated a strong association between the LAP index and depression in men (OR: 1.002, 95%CI: 1.001, 1.004) or those with hypertension (OR: 1.002, 95%CI: 1.000, 1.003). Additionally, smoothed curve fitting and GAM regression demonstrated a positive linear correlation between the LAP index and depression.Conclusions Our findings suggest that individuals with a higher LAP index may be at higher risk of depression, particularly men or those with hypertension. However, further studies are required to confirm these findings.
C1 [Dai, Mengyao; Tian, Yanghua] Anhui Med Univ, Affiliated Hosp 1, Dept Neurol, 218 Jixi Rd, Hefei 230031, Anhui, Peoples R China.
   [Zhang, Yuyang] Anhui Med Univ, Affiliated Hosp 1, Dept Urol, Hefei, Peoples R China.
   [Chen, Yang; Wang, Long] Anhui Mental Hlth Ctr, Dept Psychiat, Hefei, Peoples R China.
   [Chen, Yang; Wang, Long] Fourth Peoples Hosp Hefei, Dept Psychiat, Hefei, Peoples R China.
   [Chen, Yang; Wang, Long] Anhui Med Univ, Affiliated Psychol Hosp, Dept Psychiat, Hefei, Peoples R China.
   [Tian, Yanghua] Anhui Med Univ, Coll Mental Hlth & Psychol Sci, Hefei, Peoples R China.
   [Tian, Yanghua] Collaborat Innovat Ctr Neuropsychiat Disorders &, Hefei 230032, Peoples R China.
C3 Anhui Medical University; Anhui Medical University; Anhui Medical
   University; Anhui Medical University
RP Tian, YH (corresponding author), Anhui Med Univ, Affiliated Hosp 1, Dept Neurol, 218 Jixi Rd, Hefei 230031, Anhui, Peoples R China.
EM ayfytyh@126.com
FU National Natural Science Foundation of China [32071054]; Anhui
   Provincial Science Fund for Distinguished Young Scholars [1808085J23]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by the National Natural Science Foundation of China (No.
   32071054) and Anhui Provincial Science Fund for Distinguished Young
   Scholars (1808085J23).
CR Atlantis E, 2012, J AFFECT DISORDERS, V142, pS30, DOI 10.1016/S0165-0327(12)70006-X
   Bawadi H, 2019, NUTRIENTS, V11, DOI 10.3390/nu11051018
   Berk M, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-74
   Beurel E, 2020, NEURON, V107, P234, DOI 10.1016/j.neuron.2020.06.002
   Chatterjee S, 2016, DIABETES CARE, V39, P300, DOI 10.2337/dc15-1588
   Cho SJ, 2019, J AFFECT DISORDERS, V244, P54, DOI 10.1016/j.jad.2018.09.046
   DEFRONZO RA, 1979, AM J PHYSIOL, V237, pE214
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Ferrari AJ, 2022, LANCET PSYCHIAT, V9, P137, DOI 10.1016/S2215-0366(21)00395-3
   Fiorentino TV, 2019, BMJ OPEN DIAB RES CA, V7, DOI 10.1136/bmjdrc-2019-000911
   Gouda SI, 2022, ARCH ITAL UROL ANDRO, V94, P464, DOI 10.4081/aiua.2022.4.464
   Han AL, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-10350-5
   Haroon E, 2009, PSYCHIAT RES-NEUROIM, V171, P10, DOI 10.1016/j.pscychresns.2008.03.006
   Huang R, 2022, ANN MED, V54, P622, DOI 10.1080/07853890.2022.2039956
   Ioachimescu AG, 2010, OBESITY, V18, P1836, DOI 10.1038/oby.2009.453
   Johnson Clifford L, 2013, Vital Health Stat 2, P1
   Kahn HS, 2006, DIABETES CARE, V29, P151, DOI 10.2337/diacare.29.01.06.dc05-1805
   Kessing LV, 2020, HYPERTENSION, V76, P1263, DOI 10.1161/HYPERTENSIONAHA.120.15605
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Leonard BE, 2020, ACTA NEUROPSYCHIATR, V32, P1, DOI 10.1017/neu.2019.17
   Leonard Brian E, 2018, Acta Neuropsychiatr, V30, P1, DOI 10.1017/neu.2016.69
   Liu NZ, 2021, NUTRIENTS, V13, DOI 10.3390/nu13103330
   Lugo R, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-18705-8
   Mandavia CH, 2012, METABOLISM, V61, P1205, DOI 10.1016/j.metabol.2012.02.013
   Mazidi M, 2018, J DIABETES COMPLICAT, V32, P266, DOI 10.1016/j.jdiacomp.2017.10.007
   Milaneschi Y, 2012, J CLIN PSYCHIAT, V73, P1205, DOI 10.4088/JCP.11m07552
   Miller GE, 2003, BRAIN BEHAV IMMUN, V17, P276, DOI 10.1016/S0889-1591(03)00057-6
   Moussavi S, 2007, LANCET, V370, P851, DOI 10.1016/S0140-6736(07)61415-9
   Murray CJL, 2020, LANCET, V396, P1223, DOI [10.1016/S0140-6736(20)30752-2, 10.1016/S0140-6736(20)30925-9]
   Nascimento-Ferreira MV, 2017, CLIN NUTR, V36, P1693, DOI 10.1016/j.clnu.2016.12.020
   Palmer BF, 2015, MOL CELL ENDOCRINOL, V402, P113, DOI 10.1016/j.mce.2014.11.029
   Pearson S, 2010, DIABETES CARE, V33, P1128, DOI 10.2337/dc09-1940
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Petersen MC, 2018, PHYSIOL REV, V98, P2133, DOI 10.1152/physrev.00063.2017
   Rasgon N, 2004, J GERONTOL A-BIOL, V59, P178
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Sen ZD, 2021, BRAIN BEHAV IMMUN, V93, P335, DOI 10.1016/j.bbi.2020.12.020
   Seravalle G, 2017, PHARMACOL RES, V122, P1, DOI 10.1016/j.phrs.2017.05.013
   Shelton RC, 2010, PROG NEUROBIOL, V91, P275, DOI 10.1016/j.pneurobio.2010.04.004
   Shi YY, 2021, BMC PSYCHIATRY, V21, DOI 10.1186/s12888-021-03275-2
   Singh MK, 2019, HORM BEHAV, V108, P73, DOI 10.1016/j.yhbeh.2018.03.009
   Taverna MJ, 2011, EUR J ENDOCRINOL, V164, P559, DOI 10.1530/EJE-10-1039
   Troubat R, 2021, EUR J NEUROSCI, V53, P151, DOI 10.1111/ejn.14720
   Tsatsoulis A, 2013, METABOLISM, V62, P622, DOI 10.1016/j.metabol.2012.11.004
   WRIGHT JH, 1978, BRIT J PSYCHIAT, V132, P386, DOI 10.1192/bjp.132.4.386
   Xia C, 2012, EUR J CLIN NUTR, V66, P1035, DOI 10.1038/ejcn.2012.83
NR 46
TC 0
Z9 0
U1 3
U2 8
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0091-2174
EI 1541-3527
J9 INT J PSYCHIAT MED
JI Int. J. Psychiatr. Med.
PD NOV
PY 2024
VL 59
IS 6
BP 685
EP 701
DI 10.1177/00912174241265559
EA JUL 2024
PG 17
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA H8Z9B
UT WOS:001275140000001
PM 39044344
DA 2025-06-11
ER

PT J
AU Heinonen, I
   Rinne, P
   Ruohonen, ST
   Ruohonen, S
   Ahotupa, M
   Savontaus, E
AF Heinonen, I.
   Rinne, P.
   Ruohonen, S. T.
   Ruohonen, S.
   Ahotupa, M.
   Savontaus, E.
TI The effects of equal caloric high fat and western diet on metabolic
   syndrome, oxidative stress and vascular endothelial function in mice
SO ACTA PHYSIOLOGICA
LA English
DT Article
DE adiposity; high fat and Western diets; metabolism; oxidative stress;
   vascular function
ID LIVER-DISEASE; INSULIN-RESISTANCE; WEIGHT-GAIN; DYSFUNCTION; OBESITY;
   INDEX; MECHANISMS; EXPRESSION; RECEPTOR; MODEL
AB Aim Nutrition contributes to increased adiposity, but it remains to be determined whether high fat rather than Western diet exacerbates the development of obesity and other characteristics of metabolic syndrome and vascular function. Methods We studied the effects of high fat (45% kcal) diet (HFD) and equal caloric Western diet (WD) high in fat, sucrose and cholesterol for 8weeks in male C57B1/6N mice. Results Mice fed with HFD and WD showed substantially higher body adiposity (body fat %) compared with control mice receiving low fat (10%) diet (LFD). However, total body weight was higher only in HFD mice compared with other groups. The amount of liver triglycerides, cholesterol and oxidative damage was higher in WD mice compared with mice on LFD. There were no significant differences in fasting blood glucose or serum insulin, serum or muscle triglycerides, glucose tolerance or systolic blood pressure between the groups, but serum free fatty acids were increased in HFD mice compared with LFD. Increased levels of tissue and serum diene conjugation as a marker of oxidative stress were evident especially in WD mice. The endothelium-dependent relaxations were significantly impaired in the small mesenteric arteries of HFD mice, but not in the aorta. Maximal relaxations correlated negatively with body adiposity in WD but not in HFD mice. Conclusions The major finding in the present study is that without changing body weight, Western diet induces marked whole-body oxidative stress and elevates body adiposity, which associates with the endothelial function of resistance arteries.
C1 [Heinonen, I.; Rinne, P.; Ruohonen, S. T.; Ruohonen, S.; Savontaus, E.] Univ Turku, Dept Pharmacol Drug Dev & Therapeut, FIN-20521 Turku, Finland.
   [Heinonen, I.; Rinne, P.; Ruohonen, S. T.; Ruohonen, S.; Savontaus, E.] Univ Turku, Turku Ctr Dis Modeling, FIN-20521 Turku, Finland.
   [Heinonen, I.] Univ Turku, Turku PET Ctr, FIN-20521 Turku, Finland.
   [Heinonen, I.; Ruohonen, S. T.; Ahotupa, M.] Turku Univ Hosp, FIN-20520 Turku, Finland.
   [Heinonen, I.] Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, FIN-20521 Turku, Finland.
   [Ahotupa, M.] Univ Turku, Dept Physiol, MCA Res Lab, FIN-20521 Turku, Finland.
   [Savontaus, E.] Turku Univ Hosp, Clin Pharmacol Unit, FIN-20520 Turku, Finland.
C3 University of Turku; University of Turku; University of Turku;
   University of Turku; University of Turku; University of Turku;
   University of Turku
RP Heinonen, I (corresponding author), Univ Turku, Turku PET Ctr, POB 52, FIN-20521 Turku, Finland.
EM ilkka.heinonen@utu.fi
RI Ruohonen, Saku/MFI-3214-2025; Rinne, Petteri/N-7099-2019
OI Savontaus, Eriika/0000-0003-3421-0367
FU Finnish Funding Agency for Technology and Innovation; Academy of Finland
FX The study was supported by a grant from the Finnish Funding Agency for
   Technology and Innovation and the Academy of Finland. Ms. Raija
   Kaartosalmi and Ms. Suvi Parkkali are acknowledged for the work and
   skilful technical assistance with the laboratory assays.
CR Ahotupa M, 1997, N-S ARCH PHARMACOL, V356, P297, DOI 10.1007/PL00005054
   Aldhahi Waleed, 2003, Curr Diab Rep, V3, P293, DOI 10.1007/s11892-003-0020-2
   Alonso LC, 2012, OBESITY, V20, P1403, DOI 10.1038/oby.2012.36
   Andrikopoulos S, 2008, AM J PHYSIOL-ENDOC M, V295, pE1323, DOI 10.1152/ajpendo.90617.2008
   Anstee QM, 2006, INT J EXP PATHOL, V87, P1, DOI 10.1111/j.0959-9673.2006.00465.x
   Archer ZA, 2007, P NUTR SOC, V66, P124, DOI 10.1017/S0029665107005356
   Ayer JG, 2011, OBESITY, V19, P54, DOI 10.1038/oby.2010.114
   Brand-Miller J, 2009, J AM COLL NUTR, V28, p446S, DOI 10.1080/07315724.2009.10718110
   Bray GA, 2012, JAMA-J AM MED ASSOC, V307, P47, DOI 10.1001/jama.2011.1918
   Caballero AE, 1999, DIABETES, V48, P1856, DOI 10.2337/diabetes.48.9.1856
   de Gonzalez AB, 2010, NEW ENGL J MED, V363, P2211, DOI 10.1056/NEJMoa1000367
   Delaey C, 2002, EXP EYE RES, V75, P243, DOI 10.1006/exer.2002.2028
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Gordon JL, 2008, J BEHAV MED, V31, P5, DOI 10.1007/s10865-007-9129-0
   Grundy SM, 2012, J AM COLL CARDIOL, V59, P635, DOI 10.1016/j.jacc.2011.08.080
   Hamdy Osama, 2005, Expert Rev Cardiovasc Ther, V3, P231, DOI 10.1586/14779072.3.2.231
   Hink U, 2001, CIRC RES, V88, pE14
   Howitt L, 2012, AM J PHYSIOL-HEART C, V302, pH2464, DOI 10.1152/ajpheart.00965.2011
   Joyner MJ, 2009, J PHYSIOL-LONDON, V587, P5551, DOI 10.1113/jphysiol.2009.179432
   Kong APS, 2011, OBES REV, V12, P492, DOI 10.1111/j.1467-789X.2010.00768.x
   Kotronen A, 2007, J CLIN ENDOCR METAB, V92, P3490, DOI 10.1210/jc.2007-0482
   Kumashiro N, 2008, DIABETES, V57, P2083, DOI 10.2337/db08-0144
   Kumashiro N, 2011, P NATL ACAD SCI USA, V108, P16381, DOI 10.1073/pnas.1113359108
   Lin S, 2000, BRAIN RES, V875, P89, DOI 10.1016/S0006-8993(00)02580-4
   Mozaffarian D, 2011, NEW ENGL J MED, V364, P2392, DOI 10.1056/NEJMoa1014296
   Napoli C, 2012, CIRCULATION, V125, P2363, DOI 10.1161/CIRCULATIONAHA.111.085787
   PEIPER U, 1973, PFLUG ARCH EUR J PHY, V340, P113, DOI 10.1007/BF00588170
   Persson PB, 2013, ACTA PHYSIOL, V209, P250, DOI 10.1111/apha.12180
   Pruis MGM, 2014, ACTA PHYSIOL, V210, P215, DOI 10.1111/apha.12197
   Rinne P, 2013, CARDIOVASC RES, V97, P360, DOI 10.1093/cvr/cvs335
   Romero-Corral A, 2010, J AM COLL CARDIOL, V56, P662, DOI 10.1016/j.jacc.2010.03.063
   Ruohonen ST, 2008, DIABETES, V57, P1517, DOI 10.2337/db07-0722
   Sampey BP, 2011, OBESITY, V19, P1109, DOI 10.1038/oby.2011.18
   Samuel VT, 2012, CELL, V148, P852, DOI 10.1016/j.cell.2012.02.017
   Sánchez-Lasheras C, 2010, FRONT NEUROENDOCRIN, V31, P4, DOI 10.1016/j.yfrne.2009.08.002
   Shea JL, 2012, NUTR METAB CARDIOVAS, V22, P741, DOI 10.1016/j.numecd.2010.11.009
   Smith BW, 2011, NAT REV ENDOCRINOL, V7, P456, DOI 10.1038/nrendo.2011.72
   Spradley FT, 2013, ACTA PHYSIOL, V207, P358, DOI 10.1111/apha.12025
   Sumithran P, 2011, NEW ENGL J MED, V365, P1597, DOI 10.1056/NEJMoa1105816
   Ueno N, 2005, SHOCK, V24, P564, DOI 10.1097/01.shk.0000184285.57375.bc
   Valassi E, 2008, NUTR METAB CARDIOVAS, V18, P158, DOI 10.1016/j.numecd.2007.06.004
   Velloso LA, 2011, INT J OBESITY, V35, P1455, DOI 10.1038/ijo.2011.56
   Vial G, 2011, J HEPATOL, V54, P348, DOI 10.1016/j.jhep.2010.06.044
   Williams KJ, 2008, J CLIN INVEST, V118, P3247, DOI 10.1172/JCI35206
   Zhang HR, 2012, BASIC RES CARDIOL, V107, DOI 10.1007/s00395-011-0237-1
NR 45
TC 61
Z9 70
U1 0
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1748-1708
EI 1748-1716
J9 ACTA PHYSIOL
JI Acta Physiol.
PD JUL
PY 2014
VL 211
IS 3
BP 515
EP 527
DI 10.1111/apha.12253
PG 13
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA AJ4CA
UT WOS:000337616500008
PM 24621461
DA 2025-06-11
ER

PT J
AU Tabur, S
   Torun, AN
   Sabuncu, T
   Turan, MN
   Celik, H
   Ocak, AR
   Aksoy, N
AF Tabur, Suzan
   Torun, Ayse Nur
   Sabuncu, Tevfik
   Turan, Mehmet Nuri
   Celik, Hakim
   Ocak, Ali Riza
   Aksoy, Nurten
TI Non-diabetic metabolic syndrome and obesity do not affect serum
   paraoxonase and arylesterase activities but do affect oxidative stress
   and inflammation
SO EUROPEAN JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID DENSITY-LIPOPROTEIN; AUTOMATED-METHOD; LIVER-DISEASE; ASSOCIATION
AB Objective: Paraoxonase-1 (PON-1), which has PON and arylesterase activities, is a high-density lipoprotein (HDL)-bound antioxidant enzyme that inhibits atherosclerosis. Diabetes has been shown to have an impact on oxidative stress. The effect of metabolic syndrome (MetS) on oxidative stress and PON-1 has been shown before, and PON-1 has been found to be related with accelerated atherogenesis. This study aimed to determine the oxidative state and PON and arylesterase activities in non-diabetic MetS and non-MetS obese patients.
   Design: Thirty obese patients (3 M and 27 F) without MetS, 40 non-diabetic obese patients (3 M and 37 F) with MetS, and 30 controls (2 M and 28 F) were enrolled.
   Methods: A 75 g glucose tolerance test was performed. PON-1, PON, arylesterase, total antioxidant status (TAS), high-sensitive C-reactive protein (hsCRP), and metabolic parameters were analyzed.
   Results: PON and arylesterase activities were similar between the groups, while TAS was low in both MetS and obese groups compared to controls (P<0.01 and P<0.05 respectively). CRP was higher in the MetS group compared with the obese and control groups (P<0.01 and P<0.001 respectively). In both the obese and MetS groups, CRP showed a positive correlation with body mass index (BMI). TAS was negatively correlated with BMI, waist circumference, triglyceride levels, and systolic and diastolic blood pressures (P<0.001).
   Conclusions: Oxidative stress is altered in non-diabetic MetS and non-MetS obese patients, but PON and arylesterase activities seem not to be affected. This result may be due to the absence of diabetes, the most severe form of altered carbohydrate metabolism.
C1 [Tabur, Suzan; Torun, Ayse Nur; Sabuncu, Tevfik] Harran Univ, Sch Med, Dept Endocrinol & Metab Dis, TR-63300 Sanliurfa, Turkey.
   [Turan, Mehmet Nuri] Harran Univ, Sch Med, Dept Internal Med, TR-63300 Sanliurfa, Turkey.
   [Celik, Hakim; Ocak, Ali Riza; Aksoy, Nurten] Harran Univ, Sch Med, Dept Clin Biochem, TR-63300 Sanliurfa, Turkey.
C3 Harran University; Harran University; Harran University
RP Torun, AN (corresponding author), Harran Univ, Sch Med, Dept Endocrinol & Metab Dis, TR-63300 Sanliurfa, Turkey.
EM aysenurizol@yahoo.com
RI celik, hakim/A-1789-2016; Sabuncu, Tevfik/ABF-5291-2020; Inan,
   Nurten/AAA-8197-2021
CR Audikovszky M, 2007, NUTR METAB CARDIOVAS, V17, P268, DOI 10.1016/j.numecd.2006.03.004
   Bolukbas C, 2005, BMC INFECT DIS, V5, DOI 10.1186/1471-2334-5-95
   Demircan N, 2008, MED SCI MONITOR, V14, pCR97
   Draganov DI, 2000, J BIOL CHEM, V275, P33435, DOI 10.1074/jbc.M004543200
   ECKERSON HW, 1983, AM J HUM GENET, V35, P1126
   Erel O, 2004, CLIN BIOCHEM, V37, P112, DOI 10.1016/j.clinbiochem.2003.10.014
   Erel O, 2005, CLIN BIOCHEM, V38, P1103, DOI 10.1016/j.clinbiochem.2005.08.008
   Eschner AK, 2006, VET TECH, V27, P6
   Ferretti G, 2005, J CLIN ENDOCR METAB, V90, P1728, DOI 10.1210/jc.2004-0486
   Getz GS, 2004, CURR OPIN LIPIDOL, V15, P261, DOI 10.1097/00041433-200406000-00005
   Giugliano D, 1996, DIABETES CARE, V19, P257, DOI 10.2337/diacare.19.3.257
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   HAAGEN L, 1992, EUR J CLIN CHEM CLIN, V30, P391
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Holvoet P, 2008, Verh K Acad Geneeskd Belg, V70, P193
   Jones DP, 2006, ANTIOXID REDOX SIGN, V8, P1865, DOI 10.1089/ars.2006.8.1865
   Kabaroglu C, 2004, ACTA CARDIOL, V59, P606, DOI 10.2143/AC.59.6.2005242
   Kim CH, 2008, CLEV CLIN J MED, V75, P721, DOI 10.3949/ccjm.75.10.721
   Lubos E, 2008, FRONT BIOSCI-LANDMRK, V13, P5323, DOI 10.2741/3084
   Mackness B, 1998, ATHEROSCLEROSIS, V139, P341, DOI 10.1016/S0021-9150(98)00095-1
   Mackness M, 2004, CURR OPIN LIPIDOL, V15, P399, DOI 10.1097/01.mol.0000137227.54278.29
   Madamanchi NR, 2005, ARTERIOSCL THROM VAS, V25, P950, DOI 10.1161/01.ATV.0000161050.77646.68
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Misra A, 2008, J CLIN ENDOCR METAB, V93, pS9, DOI 10.1210/jc.2008-1595
   Paragh G, 2006, BRIT J CLIN PHARMACO, V61, P694, DOI 10.1111/j.1365-2125.2006.02565.x
   Radikova Z, 2006, EXP CLIN ENDOCR DIAB, V114, P249, DOI 10.1055/s-2006-924233
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Rösen P, 2001, DIABETES-METAB RES, V17, P189, DOI 10.1002/dmrr.196
   Sentí M, 2001, ATHEROSCLEROSIS, V156, P443, DOI 10.1016/S0021-9150(00)00680-8
   Sentí M, 2003, J CLIN ENDOCR METAB, V88, P5422, DOI 10.1210/jc.2003-030648
   Senti; Mariano, 2003, Eur J Intern Med, V14, P178, DOI 10.1016/S0953-6205(03)00041-4
   Vincent HK, 2007, DIABETES OBES METAB, V9, P813, DOI 10.1111/j.1463-1326.2007.00692.x
NR 32
TC 45
Z9 45
U1 0
U2 4
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0804-4643
EI 1479-683X
J9 EUR J ENDOCRINOL
JI Eur. J. Endocrinol.
PD MAR
PY 2010
VL 162
IS 3
BP 535
EP 541
DI 10.1530/EJE-09-0732
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 582QF
UT WOS:000276612100011
PM 20022940
DA 2025-06-11
ER

PT J
AU Tooke, JE
AF Tooke, JE
TI Possible pathophysiological mechanisms for diabetic angiopathy in type 2
   diabetes
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Article
DE pathophysiological mechanisms; diabetic angiopathy; type 2 diabetes;
   oxidative stress; endothelial function; insulin resistance
ID INSULIN-RESISTANCE; MELLITUS; ENDOTHELIUM; NIDDM; DYSFUNCTION; RISK
AB The expression of large and small vessel disease in type 2 diabetes differs from that observed in type 1, with a higher prevalence of atherosclerosis and hypertension, maculopathy rather than proliferative retinopathy, and nephropathy of a more complex nature. Such differences are mirrored by differences in vascular pathophysiology with an early impairment of microvascular vasodilatory reserve being a prominent feature. The defect appears to be endothelium dependent and in conjunction with evidence of endothelium activation suggests that the endothelium plays a crucial role in the pathogenesis of vascular disease in type 2 diabetes and may even be an intrinsic feature or common antecedent of the insulin resistance syndrome. Several cellular mechanisms may be proposed linking insulin resistance and endothelial dysfunction including (i) abnormalities of common signal transduction mechanisms, (ii) alterations in cell membrane fluidity altering the expression and/or presentation of a wide range of receptors, or (iii) changes in oxidative stress. It is intuitively unlikely that the alteration of a single signal transduction mechanism could be a common cause, particularly as aspects of endothelial dysfunction implicate different mechanisms. Accordingly, changes in oxidative stress, either stemming from glucose-mediated increased free-radical generation and/or reduction of antioxidant capacity, are strong contender mechanisms. Not only may increased oxidative stress result in the quenching of nitric oxide, neutralizing its many protective functions, but it may also damage DNA, protein structure, and membrane properties. Elucidating the links between oxidative stress, endothelial function, and insulin resistance has important implications for the prevention of diabetic angiopathy and perhaps for the prevention of diabetes itself. (C) 2000 Elsevier Science Inc. All rights reserved.
C1 Univ Exeter, Sch Postgrad Med & Vasc Hlth Sci, Dept Diabet & Vasc Med, Exeter EX2 5AX, Devon, England.
C3 University of Exeter
RP Univ Exeter, Sch Postgrad Med & Vasc Hlth Sci, Dept Diabet & Vasc Med, Barrack Rd, Exeter EX2 5AX, Devon, England.
EM j.e.tooke@exeter.ac.uk
CR Anastasiou E, 1998, DIABETES CARE, V21, P2111, DOI 10.2337/diacare.21.12.2111
   BALLETSHOFER B, 1998, DIABETOLOGIA S1, V35, P1212
   Bannan S, 1998, DIABETOLOGIA, V41, P460, DOI 10.1007/s001250050930
   DJI, ROBOMASTER S1
   Goodfellow J, 1996, BRIT MED J, V312, P744
   JAAP AJ, 1995, CLIN SCI, V89, P3, DOI 10.1042/cs0890003
   JAAP AJ, 1994, DIABETOLOGIA, V37, P214, DOI 10.1007/s001250050096
   Jaap AJ, 1997, DIABETOLOGIA, V40, P238, DOI 10.1007/s001250050669
   LEE BC, 1998, DIABETIC MED, V15, pA33
   Leeson CPM, 1997, CIRCULATION, V96, P2233
   Martin H, 1998, J VASC RES, V35, P33
   MORRIS SJ, 1995, DIABETOLOGIA, V38, P1337, DOI 10.1007/BF00401767
   Paolisso G, 1996, DIABETOLOGIA, V39, P357, DOI 10.1007/BF00418354
   PARVING HH, 1983, METABOLISM, V32, P943, DOI 10.1016/0026-0495(83)90210-X
   Sandeman D., 1990, Diabetic Med, V7, pA25
   SHORE AC, 1994, DIABETES, V43, P1198, DOI 10.2337/diabetes.43.10.1198
   Sinclair AJ., 1993, DIABETES REV, V2, P7
   Ting HH, 1996, J CLIN INVEST, V97, P22, DOI 10.1172/JCI118394
   TONG P, 1995, LANCET, V345, P357, DOI 10.1016/S0140-6736(95)90343-7
   Tooke JE, 1996, DIABETOLOGIA, V39, P745
   Tooke JE, 1998, DIABETES CARE, V21, P2047, DOI 10.2337/diacare.21.12.2047
   TOOKE JE, 1986, CLIN SCI, V70, P119, DOI 10.1042/cs0700119
   TOOKE JE, 1995, DIABETES, V44, P721, DOI 10.2337/diabetes.44.7.721
   Turner RC, 1998, LANCET, V352, P854, DOI 10.1016/s0140-6736(98)07037-8
NR 24
TC 73
Z9 82
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD JUL-AUG
PY 2000
VL 14
IS 4
BP 197
EP 200
DI 10.1016/S1056-8727(00)00083-0
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 356XW
UT WOS:000089470300005
PM 11004428
DA 2025-06-11
ER

PT J
AU Quinn, LM
   Hadjiconstantinou, M
   Brady, EM
   Bodicoat, DH
   Henson, JJ
   Hall, AP
   Davies, MJ
AF Quinn, Lauren M.
   Hadjiconstantinou, Michelle
   Brady, Emer M.
   Bodicoat, Danielle H.
   Henson, Joseph J.
   Hall, Andrew P.
   Davies, Melanie J.
TI Chronotype and well-being in adults with established type 2 diabetes: A
   cross-sectional study
SO DIABETIC MEDICINE
LA English
DT Article
DE chronotype; depression; diabetes-related distress; self-compassion; type
   2 diabetes; well-being
ID SOCIAL JETLAG; DEPRESSION; DISTRESS; SLEEP; ASSOCIATIONS; POPULATION;
   PREVALENCE; MELLITUS
AB Aims 'Chronotype' describes an individual's sleep-wake schedule, and can be classified into morning, intermediate or evening types. Evening chronotype has been widely associated with increased cardiometabolic risk and mortality in people with type 2 diabetes. We explored associations between chronotype and markers of well-being in people with type 2 diabetes. Methods Participants of the 'Chronotype of Patients with Type 2 Diabetes and Effect on Glycaemic Control' (CODEC) observational study completed questionnaires to determine chronotype (Morningness-Eveningness Questionnaire, MEQ) and concurrent measures of well-being (Diabetes-related Distress scale, Patient Health Questionnaire-9 to measure depression, and Self-Compassion Scale), as a secondary endpoint of the study. Adjusted generalised linear models were used to compare well-being between chronotype subgroups in this cohort. Results Of the 808 individuals included in the CODEC study, from convenience sampling, 476 individuals completed the psychosocial questionnaire substudy. Of these, 67% (n = 321) were male, and 86% (n = 408) were white European. From the MEQ, 24% (n = 114) were morning chronotype, 24% (n = 113) were evening and 52% (n = 249) were intermediate chronotype. Diabetes-related distress was significantly higher in evening chronotypes (exponentiated adjusted coefficient = 1.18 (CI: 1.05-1.32)), compared to morning (p(adjusted) = 0.005) and intermediate chronotypes (p(adjusted) = 0.039). Similarly, depression was significantly higher in evening chronotypes (exponentiated adjusted coefficient = 1.84 (CI: 1.28-2.65)) compared to morning (p(adjusted) = 0.001) and intermediate chronotypes (p(adjusted) = 0.016). Discussion Evening chronotype in people with type 2 diabetes may be associated with higher levels of diabetes-related distress and depression. These findings warrant further investigation to establish causality and evidence-based interventions that negate the effects of evening chronotype in people with type 2 diabetes.
C1 [Quinn, Lauren M.; Brady, Emer M.; Henson, Joseph J.; Hall, Andrew P.; Davies, Melanie J.] Univ Hosp Leicester NHS Trust, Leicester Diabet Ctr, Leicester, Leics, England.
   [Hadjiconstantinou, Michelle; Davies, Melanie J.] Univ Leicester, Coll Life Sci, Diabet Res Ctr, Leicester, Leics, England.
C3 University of Leicester; University Hospitals of Leicester NHS Trust;
   University of Leicester
RP Hadjiconstantinou, M (corresponding author), Univ Leicester, Diabet Res Ctr, Leicester, Leics, England.
EM mh333@leicester.ac.uk
RI Davies, Melanie/AFA-4210-2022
OI Davies, Melanie/0000-0002-9987-9371; Henson, Joseph/0000-0002-3898-7053;
   Bodicoat, Danielle/0000-0002-2184-4865
FU Lifestyle theme of the National Institute of Health Research (NIHR)
   Leicester Biomedical Research Centre (BRC)
FX The CODEC study was supported by the Lifestyle theme of the National
   Institute of Health Research (NIHR) Leicester Biomedical Research Centre
   (BRC).
CR Adan A, 2012, CHRONOBIOL INT, V29, P1153, DOI 10.3109/07420528.2012.719971
   Antypa N, 2016, DEPRESS ANXIETY, V33, P75, DOI 10.1002/da.22422
   Balakumar P, 2016, PHARMACOL RES, V113, P600, DOI 10.1016/j.phrs.2016.09.040
   Biss RK, 2012, EMOTION, V12, P437, DOI 10.1037/a0027071
   Brady EM, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-027773
   Cappuccio FP, 2010, DIABETES CARE, V33, P414, DOI 10.2337/dc09-1124
   Chan JWY, 2014, SLEEP, V37, P911, DOI 10.5665/sleep.3658
   Dennick K, 2017, J DIABETES COMPLICAT, V31, P898, DOI 10.1016/j.jdiacomp.2016.12.018
   Fonda Stephanie J, 2009, J Diabetes Sci Technol, V3, P117
   Friis AM, 2016, DIABETES CARE, V39, P1963, DOI 10.2337/dc16-0416
   Gaspar-Barba E, 2009, J AFFECT DISORDERS, V119, P100, DOI 10.1016/j.jad.2009.02.021
   Henderson SEM, 2019, CHRONOBIOL INT, V36, P1316, DOI 10.1080/07420528.2019.1636813
   Henson J, 2020, BMJ OPEN DIAB RES CA, V8, DOI 10.1136/bmjdrc-2020-001375
   HORNE J A, 1976, International Journal of Chronobiology, V4, P97
   Koopman ADM, 2017, J BIOL RHYTHM, V32, P359, DOI 10.1177/0748730417713572
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Larcher S, 2015, DIABETES METAB, V41, P263, DOI 10.1016/j.diabet.2014.12.004
   Lemoine P, 2013, J PSYCHIATR RES, V47, P1095, DOI 10.1016/j.jpsychires.2013.04.001
   Martorina W, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/6297162
   McCoy MA, 2019, Int J Nurs Sci, V6, P468, DOI 10.1016/j.ijnss.2019.09.003
   Morrison AE, 2021, EXP CLIN ENDOCR DIAB, V129, P413, DOI 10.1055/a-0897-3772
   Polonsky WH, 2005, DIABETES CARE, V28, P626, DOI 10.2337/diacare.28.3.626
   Reutrakul S, 2013, DIABETES CARE, V36, P2523, DOI 10.2337/dc12-2697
   Semenkovich K, 2015, DRUGS, V75, P577, DOI 10.1007/s40265-015-0347-4
   Tanenbaum ML, 2018, J DIABETES COMPLICAT, V32, P196, DOI 10.1016/j.jdiacomp.2017.10.009
   Taylor BJ, 2018, CURR PSYCHIAT REP, V20, DOI 10.1007/s11920-018-0925-8
   Tsuno N, 2005, J CLIN PSYCHIAT, V66, P1254, DOI 10.4088/JCP.v66n1008
   Wong PM, 2015, J CLIN ENDOCR METAB, V100, P4612, DOI 10.1210/jc.2015-2923
   Wyse CA, 2017, ANN MED, V49, P411, DOI 10.1080/07853890.2017.1292045
   Yaggi HK, 2006, DIABETES CARE, V29, P657, DOI 10.2337/diacare.29.03.06.dc05-0879
NR 30
TC 8
Z9 8
U1 2
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3071
EI 1464-5491
J9 DIABETIC MED
JI Diabetic Med.
PD MAR
PY 2022
VL 39
IS 3
AR e14690
DI 10.1111/dme.14690
EA SEP 2021
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA YY5TT
UT WOS:000700949100001
PM 34529279
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Mokhtari-Ardekani, A
   Fayyazishishavan, E
   Akhavanfar, R
   Abbasalizad-Farhangi, M
AF Mokhtari-Ardekani, Abnoos
   Fayyazishishavan, Ehsan
   Akhavanfar, Roozbeh
   Abbasalizad-Farhangi, Mahdieh
TI Circulating Advanced Oxidation Protein Products (AOPPs) increases the
   risk of metabolic syndrome among adults: A systematic review and
   meta-analysis
SO INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
LA English
DT Review
DE Advanced oxidation protein products; Obesity; Adult population;
   Metabolic syndrome
ID GLYCATION END-PRODUCTS; STRESS MARKERS; INFLAMMATION; ASSOCIATION;
   BIOMARKERS; OBESITY; HEALTH
AB BackgroundSeveral studies have highlighted the possible role of advanced oxidation protein products (AOPPs) in promotion of metabolic syndrome (MetS). However, due to inconsistencies in this field, we aimed to quantitatively summarize the results of studies that evaluated the association between AOPPs, with MetS indices among adult population.MethodsIn a systematic search from PubMed, Embase, and Scopus electronic databases until 15 August 2022 without language restriction, a total of 1225 articles were obtained. Finally, after duplicate removal of 632 articles and removing of 537 articles according to title/abstract, seven article was included in final meta-analysis. These articles all had observational design, were performed in adults aged more than 18 years old, and evaluated the association between circulating AOPPs and MetS.ResultsIn our meta-analysis, circulating AOPPs was 17.51 mu mol/L higher in individuals with MetS versus individuals without MetS (WMD: 17.512; CI: 12.084, 22.939; p = 0.001). Gender, age, and sample size were recognized as possible heterogeneity sources in subgrouping and meta-regression. No evidence of publication bias was reported.ConclusionAccording to the results of the current meta-analysis, higher circulating AOPPs concentrations might be associated with MetS risk among adults. Further longitudinal studies are needed to better identify the causal associations between these variables.
C1 [Mokhtari-Ardekani, Abnoos] Kerman Univ Med Sci, Inst Basic & Clin Physiol Sci & Physiol, Endocrinol & Metab Res Ctr, Res Ctr, Kerman, Iran.
   [Fayyazishishavan, Ehsan] Univ Texas Hlth Sci Ctr Houston UTHealth, Sch Publ Hlth, Dept Biostat & Data Sci, Houston, TX 77030 USA.
   [Akhavanfar, Roozbeh] Isfahan Univ Med Sci, Sch Med, Esfahan, Iran.
   [Abbasalizad-Farhangi, Mahdieh] Tabriz Univ Med Sci, Tabriz Hlth Serv Management Res Ctr, Attar Nishabouri St, Tabriz 5166614711, Iran.
C3 Kerman University of Medical Sciences; University of Texas System;
   University of Texas Health Science Center Houston; University of Texas
   School Public Health; Isfahan University of Medical Sciences; Tabriz
   University of Medical Science
RP Abbasalizad-Farhangi, M (corresponding author), Tabriz Univ Med Sci, Tabriz Hlth Serv Management Res Ctr, Attar Nishabouri St, Tabriz 5166614711, Iran.
EM abbasalizad_m@yahoo.com
RI Farhangi, Mahdieh/AAC-6758-2019; Fayyazishishavan, Ehsan/GRY-2545-2022
OI Fayyazishishavan, Ehsan/0000-0002-9548-6028
FU Research Undersecretary of Tabriz University of Medical Sciences [71887]
FX AcknowledgementsThe work was supported by a grant from Research
   Undersecretary of Tabriz University of Medical Sciences (Grant number:
   71887).
CR Al-Obaidi Z. M. J., 2018, J GLOBAL PHARMA TECH, V10, P377
   Bagyura Z, 2022, BMC CARDIOVASC DISOR, V22, DOI 10.1186/s12872-021-02451-2
   Cakir T, 2016, GINEKOL POL, V87, P321, DOI 10.5603/GP.2016.0001
   D'souza JMP, 2016, SCAND J CLIN LAB INV, V76, P51, DOI 10.3109/00365513.2015.1092048
   de Mattos AM, 2014, INT J VITAM NUTR RES, V84, P261, DOI 10.1024/0300-9831/a000212
   Descamps-Latscha A, 2005, AM J KIDNEY DIS, V45, P39, DOI 10.1053/j.ajkd.2004.09.011
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Gallegos-Gonzalez G, 2021, AM J HEALTH BEHAV, V45, P1091, DOI 10.5993/AJHB.45.6.12
   Gokalp G, 2020, ARCH CLIN PSYCHIAT, V47, P130, DOI 10.1590/0101-60830000000248
   Gradinaru D, 2018, EXP CLIN ENDOCR DIAB, V126, P445, DOI 10.1055/s-0043-123825
   Gradinaru D, 2013, J PROTEOMICS, V92, P313, DOI 10.1016/j.jprot.2013.03.034
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Gryszczynska B, 2017, BIOMED RES INT, V2017, DOI 10.1155/2017/4975264
   Guerra ZC, 2022, AM J HEALTH BEHAV, V46, P324, DOI 10.5993/AJHB.46.3.11
   Heidari F, 2020, LIFE SCI, V260, DOI 10.1016/j.lfs.2020.118422
   Higgins JPT, 2002, STAT MED, V21, P1539, DOI 10.1002/sim.1186
   Kalousova M, 2004, Prague Med Rep, V105, P21
   Kalousová M, 2002, PHYSIOL RES, V51, P597, DOI 10.33549/physiolres.930234
   Klisic A, 2019, J MED BIOCHEM, V38, P361, DOI 10.2478/jomb-2018-0035
   Koborová I, 2018, ACTA PAEDIATR, V107, P2137, DOI 10.1111/apa.14372
   Korkmaz GG, 2013, METABOLISM, V62, P828, DOI 10.1016/j.metabol.2013.01.002
   Kraml PJ, 2013, ANN NUTR METAB, V62, P7, DOI 10.1159/000343049
   Loi LH, 2022, J COMPL MED RES, V13, P24, DOI 10.5455/jcmr.2022.13.02.04
   Leman MA, 2021, AM J HEALTH BEHAV, V45, P268, DOI 10.5993/AJHB.45.2.7
   Milan Z, REV PSICOL DEPORTE, V31, P1
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Morelli NR, 2018, ARCH ENDOCRIN METAB, V62, P309, DOI 10.20945/2359-3997000000036
   Ou HX, 2017, CARDIOVASC TOXICOL, V17, P1, DOI 10.1007/s12012-016-9377-8
   Pan HZ, 2010, ACTA DIABETOL, V47, pS71, DOI 10.1007/s00592-009-0128-1
   Patil Manisha B, 2021, J Carcinog, V20, P15, DOI 10.4103/jcar.jcar_10_21
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Rasool M, 2019, SAUDI J BIOL SCI, V26, P334, DOI 10.1016/j.sjbs.2018.08.024
   Samson SL, 2014, ENDOCRIN METAB CLIN, V43, P1, DOI 10.1016/j.ecl.2013.09.009
   Senormanci G, 2021, ARCH CLIN PSYCHIAT, V48, DOI 10.15761/0101-60830000000287
   Simeon Jodi, 2021, J Carcinog, V20, P8, DOI 10.4103/jcar.JCar_20_20
   Sutherland JP, 2004, METAB SYNDR RELAT D, V2, P82, DOI 10.1089/met.2004.2.82
   Venturini D, 2015, NUTR RES, V35, P759, DOI 10.1016/j.nutres.2015.06.013
   Witko-Sarsat V, 1998, J IMMUNOL, V161, P2524
   Zurawska-Plaksej E, 2019, MED LITH, P55
NR 39
TC 0
Z9 0
U1 1
U2 9
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0973-3930
EI 1998-3832
J9 INT J DIABETES DEV C
JI Int. Diabetes Dev. Ctries.
PD DEC
PY 2023
VL 43
IS 6
BP 847
EP 855
DI 10.1007/s13410-023-01178-4
EA MAR 2023
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA U7TH6
UT WOS:000959322200001
DA 2025-06-11
ER

PT J
AU Wang, XL
   Zhang, L
   Youker, K
   Zhang, MX
   Wang, J
   LeMaire, SA
   Coselli, JS
   Shen, YH
AF Wang, Xing Li
   Zhang, Lin
   Youker, Keith
   Zhang, Ming-Xiang
   Wang, Jian
   LeMaire, Scott A.
   Coselli, Joseph S.
   Shen, Ying H.
TI Free fatty acids inhibit insulin signaling-stimulated endothelial nitric
   oxide synthase activation through upregulating PTEN or inhibiting Akt
   kinase
SO DIABETES
LA English
DT Article
ID RECEPTOR SUBSTRATE-1; SKELETAL-MUSCLE; RISK-FACTOR; IKK-BETA; KAPPA-B;
   RESISTANCE; PHOSPHORYLATION; OBESITY; P38; PATHWAY
AB In metabolic syndrome, a systemic deregulation of the insulin pathway leads to a combined deregulation of insulin-regulated metabolism and cardiovascular functions. Free fatty acids (FFAs), which are increased in metabolic syndrome, inhibit insulin signaling and induce metabolic insulin resistance. This study was designed to examine FFAs' effects on vascular insulin signaling and endothelial nitric oxide (NO) synthase (eNOS) activation in endothelial cells. We showed that FFAs inhibited insulin signaling and eNOS activation through different mechanisms. While linoleic acid inhibited Akt-mediated eNOS phosphorylation, palmitic acid appeared to affect the upstream signaling. Upregulation of PTEN (phosphatase and tensin homolog deleted on chromosome 10) activity and transcription by palmitic acid mediated the inhibitory effects on insulin signaling. We further found that activated stress signaling p38, but not Jun NH2-terminal kinase, was involved in PTEN upregulation. The p38 target transcriptional factor activating transcription factor (ATF)-2 bound to the PTEN promoter, which was increased by palmitic acid treatment. In summary, both palmitic acid and linoleic acid exert inhibitory effect on insulin signaling and eNOS activation in endothelial cells. Palmitic acid inhibits insulin signaling by promoting PTEN activity and its transcription through p38 and its downstream transcription factor ATF-2. Our findings suggest that FFA-mediated inhibition of vascular insulin signaling and eNOS activation may contribute to cardiovascular diseases in metabolic syndrome.
C1 Baylor Coll Med, Michael E DeBakey Dept Surg, Houston, TX 77030 USA.
C3 Baylor College of Medicine
RP Shen, YH (corresponding author), Baylor Coll Med, Michael E DeBakey Dept Surg, MS NAB 2010,1 Baylor Plaza, Houston, TX 77030 USA.
EM xlwang@bcm.edu; hyshen@bcm.edu
RI wang, xingli/MHR-1399-2025; shen, ying/HHS-5635-2022
OI LeMaire, Scott/0000-0002-8736-4266; Youker, Keith/0000-0003-2535-7973
CR Aguirre V, 2000, J BIOL CHEM, V275, P9047, DOI 10.1074/jbc.275.12.9047
   Aljada A, 2000, METABOLISM, V49, P147, DOI 10.1016/S0026-0495(00)91039-4
   Aljada A, 2002, METABOLISM, V51, P487, DOI 10.1053/meta.2002.31339
   Arkan MC, 2005, NAT MED, V11, P191, DOI 10.1038/nm1185
   Artwohl M, 2004, FASEB J, V18, P146, DOI 10.1096/fj.03-0301fje
   Baron AD, 1999, AM J CARDIOL, V84, p25J
   Boden G, 2003, EXP CLIN ENDOCR DIAB, V111, P121, DOI 10.1055/s-2003-39781
   Bonora E, 1998, DIABETES, V47, P1643, DOI 10.2337/diabetes.47.10.1643
   Cai DS, 2005, NAT MED, V11, P183, DOI 10.1038/nm1166
   Carlson CJ, 2003, DIABETES, V52, P634, DOI 10.2337/diabetes.52.3.634
   Carlsson M, 2000, ARTERIOSCL THROM VAS, V20, P1588, DOI 10.1161/01.ATV.20.6.1588
   Dandona P, 2001, J CLIN ENDOCR METAB, V86, P3257, DOI 10.1210/jc.86.7.3257
   de Alvaro C, 2004, J BIOL CHEM, V279, P17070, DOI 10.1074/jbc.M312021200
   de Jongh RT, 2004, DIABETES, V53, P2873, DOI 10.2337/diabetes.53.11.2873
   DeFea K, 1997, J BIOL CHEM, V272, P31400, DOI 10.1074/jbc.272.50.31400
   Dresner A, 1999, J CLIN INVEST, V103, P253, DOI 10.1172/JCI5001
   Egan BM, 1999, PROSTAG LEUKOTR ESS, V60, P411, DOI 10.1016/S0952-3278(99)80022-2
   Gratton JP, 2000, J BIOL CHEM, V275, P22268, DOI 10.1074/jbc.M001644200
   GROOP LC, 1991, J CLIN ENDOCR METAB, V72, P96, DOI 10.1210/jcem-72-1-96
   Haffner S, 2003, CIRCULATION, V108, P1541, DOI 10.1161/01.CIR.0000088845.17586.EC
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Hockings SC, 1998, P NATL ACAD SCI USA, V95, P1410, DOI 10.1073/pnas.95.4.1410
   Huang C, 2002, DIABETES, V51, P2090, DOI 10.2337/diabetes.51.7.2090
   Jiang GQ, 2002, FRONT BIOSCI-LANDMRK, V7, pD904
   Jouven X, 2001, CIRCULATION, V104, P756, DOI 10.1161/hc3201.094151
   Kereiakes DJ, 2003, CIRCULATION, V108, P1552, DOI 10.1161/01.CIR.0000093203.00632.2B
   Kim F, 2005, ARTERIOSCL THROM VAS, V25, P989, DOI 10.1161/01.ATV.0000160549.60980.a8
   Koistinen HA, 2003, DIABETOLOGIA, V46, P1324, DOI 10.1007/s00125-003-1196-3
   Kuhlmann J, 2003, DIABETES, V52, P138, DOI 10.2337/diabetes.52.1.138
   Kurlawalla-Martinez C, 2005, MOL CELL BIOL, V25, P2498, DOI 10.1128/MCB.25.6.2498-2510.2005
   Laws A, 1997, ARTERIOSCL THROM VAS, V17, P64, DOI 10.1161/01.ATV.17.1.64
   Lee YH, 2003, J BIOL CHEM, V278, P2896, DOI 10.1074/jbc.M208359200
   Leslie NR, 2002, CELL SIGNAL, V14, P285, DOI 10.1016/S0898-6568(01)00234-0
   Manning AM, 2003, NAT REV DRUG DISCOV, V2, P554, DOI 10.1038/nrd1132
   Morrow VA, 2003, J BIOL CHEM, V278, P31629, DOI 10.1074/jbc.M212831200
   Nicholson KM, 2002, CELL SIGNAL, V14, P381, DOI 10.1016/S0898-6568(01)00271-6
   Shen YH, 2006, J BIOL CHEM, V281, P7727, DOI 10.1074/jbc.M511105200
   Staiger H, 2004, DIABETES, V53, P3209, DOI 10.2337/diabetes.53.12.3209
   Steinberg HO, 1997, J CLIN INVEST, V100, P1230, DOI 10.1172/JCI119636
   Steinberg HO, 2000, DIABETES, V49, P1231, DOI 10.2337/diabetes.49.7.1231
   Stiles B, 2004, P NATL ACAD SCI USA, V101, P2082, DOI 10.1073/pnas.0308617100
   SVEDBERG J, 1990, DIABETES, V39, P570, DOI 10.2337/diabetes.39.5.570
   Takahashi S, 2003, J BIOL CHEM, V278, P30821, DOI 10.1074/jbc.M304471200
   Tan Y, 1996, EMBO J, V15, P4629, DOI 10.1002/j.1460-2075.1996.tb00840.x
   Tripathy D, 2003, DIABETES, V52, P2882, DOI 10.2337/diabetes.52.12.2882
   Vazquez F, 2000, MOL CELL BIOL, V20, P5010, DOI 10.1128/MCB.20.14.5010-5018.2000
   Vazquez F, 2001, J BIOL CHEM, V276, P48627, DOI 10.1074/jbc.C100556200
   Wijesekara N, 2005, MOL CELL BIOL, V25, P1135, DOI 10.1128/MCB.25.3.1135-1145.2005
   Wyatt AW, 2002, FASEB J, V16, P1584, DOI 10.1096/fj.01-0125com
   Zeng GY, 2000, CIRCULATION, V101, P1539, DOI 10.1161/01.CIR.101.13.1539
NR 50
TC 187
Z9 223
U1 0
U2 9
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD AUG
PY 2006
VL 55
IS 8
BP 2301
EP 2310
DI 10.2337/db05-1574
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 069SK
UT WOS:000239468300017
PM 16873694
OA hybrid
DA 2025-06-11
ER

PT J
AU Kravchenko, LS
   Appelhans, OL
   Poliakov, AE
   Borysiuk, IY
   Ivanova, YI
   Neskoromna, NV
   Rosumenko, MV
AF Kravchenko, L. S.
   Appelhans, O. L.
   Poliakov, A. E.
   Borysiuk, I. Yu.
   Ivanova, Y. I.
   Neskoromna, N. V.
   Rosumenko, M. V.
TI QUERCETIN EFFECTIVENESS IN THE COMPLEX HYPOLIPIDEMIC THERAPY OF PATIENTS
   WITH NONALCOHOLIC FATTY LIVER DISEASE WITH METABOLIC SYNDROME
SO WORLD OF MEDICINE AND BIOLOGY
LA English
DT Article
DE metabolic syndrome; nonalcoholic fatty liver disease; hypolipidemic
   therapy; quercetin; inflammation
AB 86 patients with metabolic syndrome and comorbid nonalcoholic fatty liver disease were carried out general clinical and laboratory-instrumental examinations. After registration of the initial data, the patients were divided into 2 groups: 41 patients with the use of rosuvastatin were added quercetin 40 mg 3 times a day for 3 months to the basic therapy (group 1). The basic therapy with rosuvastatin only was carried out in 45 patients (group 2). After the treatment on the 90th day, positive changes in lipid metabolism were registered in all the patients. The group 2 patients had a decrease in the level of low-density lipoproteins by 21.2 % (p<0.05), an increase in high-density lipoproteins by 43.3 % (p<0.05). The liver transaminase activity was lower by 15.0 %, concentration of proinflammatory interleukin-6 and cytokeratin-18 - by 10.0 % (p>0.05). In patients of the group 1 the level of low-density lipoproteins decreased by 39.5 % (p<0.05), the triglycerides - twice, activity of transaminase - by 30.0 % (p<he high-density lipoproteins level increased by 72.0 % (p<0.05). Interleukins and cytokeratin-18 concentration reliably decreased by 23.0 % (p<0.05) (p=0.001). It was found that the comorbid course of the nonalcoholic fatty liver disease is accompanied by an increase in the oxidative stress intensity, which is determined by increased level in the blood of the end products of lipid peroxidation - malondialdehyde - on average 3.8 times (p<0.05). The use of quercetin in the complex therapy of the nonalcoholic fatty liver disease contributes to a reliable reduction in the oxidative stress intensity, an increase in the antioxidant protection activity (superoxide dismutase), the consequence of which is a significant reduction in the hepatocytes apoptosis process (decrease in cytokeratine-18 level 1.27 times as much).
C1 [Kravchenko, L. S.; Appelhans, O. L.; Poliakov, A. E.; Borysiuk, I. Yu.; Ivanova, Y. I.; Neskoromna, N. V.; Rosumenko, M. V.] Odessa Natl Med Univ, Odessa, Ukraine.
C3 Odessa National Medical University
RP Kravchenko, LS (corresponding author), Odessa Natl Med Univ, Odessa, Ukraine.
EM lyudmila.kravchenko.52@gmail.com
RI Borysiuk, Iryna/AAV-8038-2021; Appel'hans, Olena/HTO-4206-2023
OI Appel'hans, Olena/0000-0002-2344-6502
FU  [0121U00263]
FX The study is a fragment of the research project "Comorbid conditions in
   patients with metabolic syndrome: familial hypercholesterolemia, fatty
   hepatosis, periodontopathies (pathogenesis, diagnosis, correction)",
   state registration number 0121U00263
CR [Anonymous], 2013, Cardiovascular Therapy and Prevention, V12, P41
   [Anonymous], 2017, RUSS J CARDIOL, V5, P7
   Bilovol OM, 2021, WORLD MED BIOL, V75, P18, DOI 10.26724/2079-8334-2021-1-75-18-22
   Bischoff SC, 2021, MODERN GASTROENTEROL, V2, P28, DOI [10.30978/MG-2021-2-28, DOI 10.30978/MG-2021-2-28]
   Bulatova IA, 2014, SOVREMENNYIE PROBLEM, V2, P41
   Chorna VV, 2020, VISNYK VINNYTSKOHO N, V24, P158, DOI [10.31393/reports-vnmedical-2020-24, DOI 10.31393/REPORTS-VINMEDICAL-2020-24(1)-31]
   Dynnyk NV, 2016, UKRAYINSKYY NAUKOVO, V2, P12
   Finck BN, 2018, DIABETES, V67, P2485, DOI 10.2337/dbi18-0024
   Goryachkovskiy AM, 2005, KLIN BIOKHIMIYA LAB
   Hernandez-Baixauli J, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030806
   Kang YE, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0154003
   Lishchyna OM, 2014, NAKAZ MOZ UKRAINY
   Miltonprabu S, 2017, FOOD CHEM TOXICOL, V108, P365, DOI 10.1016/j.fct.2016.08.034
   Parkhomenko A, 2018, EUR HEART J, V39, P431
   Sporea I, 2018, J GASTROINTEST LIVER, V27, P439, DOI 10.15403/jgld.2014.1121.274.quo
NR 15
TC 1
Z9 1
U1 0
U2 1
PU SCIENTIFIC SOC ANATOMISTS HISTOLOGISTS & EMBRYOLOGISTS UKRAINE
PI POLTAVA
PA VUL SHEVCHENKA 23, POLTAVA, 36024, UKRAINE
SN 2079-8334
J9 WORLD MED BIOL
JI World Med. Biol.
PY 2022
VL 81
IS 3
BP 76
EP 82
DI 10.26724/2079-8334-2022-3-81-76-82
PG 7
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA J9XU2
UT WOS:001013090600015
DA 2025-06-11
ER

PT J
AU Fariña, JP
   García, ME
   Alzamendi, A
   Giovambattista, A
   Marra, CA
   Spinedi, E
   Gagliardino, JJ
AF Pablo Farina, Juan
   Elisa Garcia, Maria
   Alzamendi, Ana
   Giovambattista, Andres
   Alberto Marra, Carlos
   Spinedi, Eduardo
   Jose Gagliardino, Juan
TI Antioxidant treatment prevents the development of fructose-induced
   abdominal adipose tissue dysfunction
SO CLINICAL SCIENCE
LA English
DT Article
DE abdominal adipocyte; adipokine; fructose-rich diet; insulin signalling;
   lipid metabolism; metabolic syndrome
ID SUGAR-SWEETENED BEVERAGES; NADPH OXIDASE ACTIVATION; SUCROSE-RICH DIET;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; METABOLIC-SYNDROME;
   GLUCOSE-METABOLISM; PANCREATIC-ISLETS; NAD(P)H OXIDASE; FEMALE RATS
AB In the present study, we tested the effect of OS (oxidative stress) inhibition in rats fed on an FRD [fructose-rich diet; 10% (w/v) in drinking water] for 3 weeks. Normal adult male rats received a standard CD (commercial diet) or an FRD without or with an inhibitor of NADPH oxidase, APO (apocynin; 5 mM in drinking water; CD-APO and FRD-APO). We thereafter measured plasma OS and metabolic-endocrine markers, AAT (abdominal adipose tissue) mass and cell size, FA (fatty acid) composition (content and release), OS status, LEP (leptin) and IRS (insulin receptor substrate)-1/IRS-2 mRNAs, ROS (reactive oxygen species) production, NADPH oxidase activity and LEP release by isolated AAT adipocytes. FRD-fed rats had larger AAT mass without changes in body weight, and higher plasma levels of TAG (triacylglycerol), FAs, TBARS (thiobarbituric acid-reactive substance) and LEP Although no significant changes in glucose and insulin plasma levels were observed in these animals, their HOMA-IR (homoeostasis model assessment of insulin resistance) values were significantly higher than those of CD. The AAT from FRD-fed rats had larger adipocytes, higher saturated FA content, higher NADPH oxidase activity, greater ROS production, a distorted FA content/release pattern, lower insulin sensitivity together with higher and lower mRNA content of LEP and IRS-1-/2 respectively, and released a larger amount of LEP The development of all the clinical, OS, metabolic, endocrine and molecular changes induced by the FRD were significantly prevented by APO co-administration. The fact that APO treatment prevented both changes in NADPH oxidase activity and the development of all the FRD-induced AAT dysfunctions in normal rats strongly suggests that OS plays an important role in the FRD-induced MS (metabolic syndrome) phenotype.
C1 [Pablo Farina, Juan; Elisa Garcia, Maria; Jose Gagliardino, Juan] Natl Univ La Plata, Sch Med, PAHO WHO Collaborating Ctr Diabet, UNLP CONICET LA PLATA,CENEXA, La Plata, Buenos Aires, Argentina.
   [Alzamendi, Ana; Giovambattista, Andres; Spinedi, Eduardo] CONICET LA PLATA, CICPBA, IMBICE, Neuroendocrine Unit, La Plata, Buenos Aires, Argentina.
   [Alberto Marra, Carlos] Natl Univ La Plata, Sch Med, INIBIOLP, UNLP CONICET LA PLATA, La Plata, Buenos Aires, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   National University of La Plata; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); National University of La Plata;
   Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
RP Gagliardino, JJ (corresponding author), Natl Univ La Plata, Sch Med, PAHO WHO Collaborating Ctr Diabet, UNLP CONICET LA PLATA,CENEXA, La Plata, Buenos Aires, Argentina.
EM direccion@cenexa.org
RI Spinedi, Eduardo/F-2455-2016
OI Alzamendi, Ana/0000-0003-4126-1103
FU Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
   [PIP2009-0704, PIP2009-5020, 2010-0697]; Fondation pour la Recherche en
   Endocrinologie, Diabetologie et Metabolisme (FPREDM) [2011/2012]; Fondo
   para la Investigacion Cientifica y Tecnologica (FONCyT) [PICT 2001-1051]
FX This study was supported by the Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET) [grant numbers PIP2009-0704 (to E.S.),
   PIP2009-5020 (to J.J.G.) and 2010-0697 (to C.A.M.)], the Fondation pour
   la Recherche en Endocrinologie, Diabetologie et Metabolisme (FPREDM)
   [grant number 2011/2012 (to E.S.)] and the Fondo para la Investigacion
   Cientifica y Tecnologica (FONCyT) [grant number PICT 2001-1051 (to
   E.S)].
CR Alam SE, 2012, CAN J PHYSIOL PHARM, V90, P989, DOI [10.1139/y2012-105, 10.1139/Y2012-105]
   Alzamendi A, 2010, OBESITY, V18, P441, DOI 10.1038/oby.2009.255
   Alzamendi A, 2009, ENDOCRINE, V35, P227, DOI 10.1007/s12020-008-9143-1
   ASHCROFT SJ, 1970, BIOCHEM J, V118, P143, DOI 10.1042/bj1180143
   Barbieri SS, 2004, FREE RADICAL BIO MED, V37, P156, DOI 10.1016/j.freeradbiomed.2004.04.020
   Basciano Heather, 2005, Nutr Metab (Lond), V2, P5, DOI 10.1186/1743-7075-2-5
   BORKMAN M, 1993, NEW ENGL J MED, V328, P238, DOI 10.1056/NEJM199301283280404
   Brenner R. R., 2003, FATTY ACIDS, V68, P151
   Brownlee M, 2005, DIABETES, V54, P1615, DOI 10.2337/diabetes.54.6.1615
   Cavarape A, 2001, J ENDOCRINOL INVEST, V24, P838, DOI 10.1007/BF03343940
   CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1006/abio.1987.9999
   Cohen B, 1996, SCIENCE, V274, P1185, DOI 10.1126/science.274.5290.1185
   Couillard C, 2000, INT J OBESITY, V24, P782, DOI 10.1038/sj.ijo.0801227
   Cui CM, 2007, CLIN EXP PHARMACOL P, V34, P304, DOI 10.1111/j.1440-1681.2007.04554.x
   Curtis JM, 2012, J BIOL CHEM, V287, P32967, DOI 10.1074/jbc.M112.400663
   de Koning L, 2011, AM J CLIN NUTR, V93, P1321, DOI 10.3945/ajcn.110.007922
   Delbosc S, 2005, ATHEROSCLEROSIS, V179, P43, DOI 10.1016/j.atherosclerosis.2004.10.018
   Faure P, 1999, DIABETES, V48, P353, DOI 10.2337/diabetes.48.2.353
   Faure P., 1997, J NUTR, V127, P103
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Giovambattista A, 2000, NEUROENDOCRINOLOGY, V72, P341, DOI 10.1159/000054603
   Giovambattista A, 2008, VITAM HORM, V77, P171, DOI 10.1016/S0083-6729(06)77008-X
   Giroix MH, 1999, ENDOCRINOLOGY, V140, P5556, DOI 10.1210/en.140.12.5556
   Grundy SM, 2004, CIRCULATION, V109, P551, DOI 10.1161/01.CIR.0000112379.88385.67
   GUTMAN RA, 1987, METABOLISM, V36, P1013, DOI 10.1016/0026-0495(87)90019-9
   Hajduch E, 1998, DIABETOLOGIA, V41, P821, DOI 10.1007/s001250050993
   Heumüller S, 2008, HYPERTENSION, V51, P211, DOI 10.1161/HYPERTENSIONAHA.107.100214
   Hu FB, 2010, PHYSIOL BEHAV, V100, P47, DOI 10.1016/j.physbeh.2010.01.036
   HWANG IS, 1987, HYPERTENSION, V10, P512, DOI 10.1161/01.HYP.10.5.512
   Johnson DK, 2002, ENDOTHELIUM-J ENDOTH, V9, P191, DOI 10.1080/10623320213638
   Krempler F, 1998, ARTERIOSCL THROM VAS, V18, P1686, DOI 10.1161/01.ATV.18.11.1686
   Kyriazis GA, 2012, P NATL ACAD SCI USA, V109, pE524, DOI 10.1073/pnas.1115183109
   Litherland GJ, 2004, MOL CELL BIOCHEM, V261, P23, DOI 10.1023/B:MCBI.0000028734.77867.d2
   Maiztegui B, 2011, CLIN SCI, V120, P73, DOI 10.1042/CS20100372
   Malik VS, 2010, DIABETES CARE, V33, P2477, DOI 10.2337/dc10-1079
   McElroy W. D., 1974, BIOSTATISTICAL ANAL
   McGuinness OP, 2003, CURR OPIN CLIN NUTR, V6, P441, DOI 10.1097/01.mco.0000078990.96795.cd
   Miatello R, 2005, AM J HYPERTENS, V18, P864, DOI 10.1016/j.amjhyper.2004.12.012
   Moini H, 2002, TOXICOL APPL PHARM, V182, P84, DOI 10.1006/taap.2002.9437
   Montanaro MA, 2005, PROSTAG LEUKOTR ESS, V72, P241, DOI 10.1016/j.plefa.2004.11.003
   Moreno G, 2006, INT J OBESITY, V30, P73, DOI 10.1038/sj.ijo.0803109
   Oliveira HR, 2003, DIABETES, V52, P1457, DOI 10.2337/diabetes.52.6.1457
   Peters EA, 2001, FREE RADICAL BIO MED, V31, P1442, DOI 10.1016/S0891-5849(01)00725-0
   Popkin BM, 2010, PHYSIOL BEHAV, V100, P4, DOI 10.1016/j.physbeh.2009.12.022
   Rebolledo OR, 2008, HORM METAB RES, V40, P794, DOI 10.1055/s-2008-1081502
   Schrenzel J, 1998, NATURE, V392, P734, DOI 10.1038/33725
   SENER A, 1988, ARCH BIOCHEM BIOPHYS, V261, P16, DOI 10.1016/0003-9861(88)90099-9
   Stefanska J, 2008, MEDIAT INFLAMM, V2008, DOI 10.1155/2008/106507
   Verma S, 1997, EUR J PHARMACOL, V322, pR1, DOI 10.1016/S0014-2999(97)00104-0
   Wei YR, 2007, J NUTR BIOCHEM, V18, P1, DOI 10.1016/j.jnutbio.2006.03.013
   Welder K., 1997, J ENDOCRINOL, V155, pR5
   Xu XJ, 2012, J LIPID RES, V53, P792, DOI 10.1194/jlr.P022905
NR 52
TC 31
Z9 32
U1 0
U2 20
PU PORTLAND PRESS LTD
PI LONDON
PA THIRD FLOOR, EAGLE HOUSE, 16 PROCTER STREET, LONDON WC1V 6 NX, ENGLAND
SN 0143-5221
J9 CLIN SCI
JI Clin. Sci.
PD JUL
PY 2013
VL 125
IS 1-2
BP 87
EP 97
DI 10.1042/CS20120470
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 154YE
UT WOS:000319711800011
PM 23384123
OA Green Published
DA 2025-06-11
ER

PT J
AU Olgar, Y
   Tuncay, E
   Billur, D
   Turan, B
AF Olgar, Yusuf
   Tuncay, Erkan
   Billur, Deniz
   Turan, Belma
TI Bimodal Effects of P2Y12 Antagonism on Matrix
   Metalloproteinase-Associated Contractile Dysfunction in
   Insulin-Resistant Mammalian Heart
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Metabolic syndrome; Heart dysfunction; Ticagrelor; Matrix
   metalloproteinase; Zinc
ID METABOLIC-SYNDROME; EXTRACELLULAR-MATRIX; DIETARY SELENIUM; VITAMIN-E;
   TICAGRELOR; STRESS; GLUCOSE; ZINC
AB The matrix metalloproteinases (MMPs) contribute to matrix remodeling in diabetes via tissue degradation; however, their contributions can be different depending on the pathology. For instance, MMPs are elevated in acute stress hyperglycemia, whereas they can be degraded in chronic hyperglycemia. Since studies emphasize the possible cardioprotective effect of ticagrelor (Tica) beyond its antiplatelet action, we aimed to examine whether Tica treatment can reverse the depressed heart function of metabolic syndrome (MetS) rats via affecting the expression levels of MMPs. Tica treatment of high-carbohydrate-induced MetS rats could not affect significantly the depressed contractile activity of Langendorff-perfused heart preparations. On the other hand, the Tica treatment provided a significant recovery in the reduced relaxation activity of the aortic preparations from the same animals. Histological examination of the hearts demonstrated marked damages in Mets rats, such as increases in the number of foamy cells and accumulation of collagen fiber and increases in the elastic lamellar irregularity of tunica media, while Tica treatment provided a slight improvement in the structure of left ventricle tissue. We also could not obtain a significant reverse in the high cytosolic labile Zn2+ ([Zn2+](i)) with the treatment of cardiomyocytes with Tica. Furthermore, Tica treatment of MetS rats could not significantly reverse the degraded protein levels of MMP-2 and MMP-9 in the heart, as well. Overall, we demonstrated that Tica treatment of MetS rats has no significant benefits on the depressed heart function, although provide a significant beneficial impact on vascular relaxation. This action of Tica may be through its lack of action on both MMP degradation and high [Zn2+](i), which can further precipitate in cleavage of extracellular matrix in the heart.
C1 [Olgar, Yusuf; Tuncay, Erkan; Turan, Belma] Ankara Univ, Fac Med, Dept Biophys, Ankara, Turkey.
   [Billur, Deniz] Ankara Univ, Fac Med, Dept Histol & Embryol, Ankara, Turkey.
   [Turan, Belma] Lokman Hekim Univ, Fac Med, Dept Biophys, Ankara, Turkey.
C3 Ankara University; Ankara University; Lokman Hekim University
RP Turan, B (corresponding author), Ankara Univ, Fac Med, Dept Biophys, Ankara, Turkey.; Turan, B (corresponding author), Lokman Hekim Univ, Fac Med, Dept Biophys, Ankara, Turkey.
EM belma.turan@medicine.ankara.edu.tr
RI TURAN, Belma/AAG-8084-2020; olğar, yusuf/I-8960-2016; Billur,
   Deniz/N-4933-2018; TUNCAY, ERKAN/AAG-8065-2020
FU Scientific and Technological Research Council of Turkey [SGAB-216S979]
FX This work was supported by grants (No. SGAB-216S979) from The Scientific
   and Technological Research Council of Turkey.
CR Akdas S, 2020, BIOL TRACE ELEM RES, V198, P16, DOI 10.1007/s12011-020-02046-6
   Berg G, 2014, HORM MOL BIOL CLIN I, V17, P79, DOI 10.1515/hmbci-2013-0069
   Berteaux D, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-23050-w
   Bonnans C, 2014, NAT REV MOL CELL BIO, V15, P786, DOI 10.1038/nrm3904
   Calligaris SD, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0060931
   Capodanno D, 2010, EXPERT REV CARDIOVAS, V8, P151, DOI 10.1586/ERC.09.172
   Holanda AOD, 2017, REV ASSOC MED BRAS, V63, P78, DOI 10.1590/1806-9282.63.01.78
   Durak A, 2020, CARDIOVASC DRUG THER, V34, P487, DOI 10.1007/s10557-020-06974-2
   Durak A, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0790-0
   Durak A, 2017, CAN J PHYSIOL PHARM, V95, P1335, DOI 10.1139/cjpp-2017-0054
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   FUKADA T., 2014, ZINC SIGNALS CELLULA
   Guarner V, 2012, AGING DIS, V3, P269
   Hopps E, 2012, EUR J INTERN MED, V23, P99, DOI 10.1016/j.ejim.2011.09.012
   Hosford GE, 2004, PEDIATR RES, V56, P26, DOI 10.1203/01.PDR.0000130658.45564.1F
   Hua YN, 2009, PHARMACOLOGY, V83, P18, DOI 10.1159/000166183
   Ilkun O, 2013, CURR PHARM DESIGN, V19, P4806, DOI 10.2174/1381612811319270003
   Kadoglou NPE, 2010, DIABETES METAB, V36, P144, DOI 10.1016/j.diabet.2009.11.004
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Kucuk M, 2015, CARDIOVASC DRUG THER, V29, P419, DOI 10.1007/s10557-015-6617-2
   Kuliczkowski W, 2017, BIOMED RES INT, V2017, DOI 10.1155/2017/9352015
   Lachowski D, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-43759-6
   Liu O, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051707
   McLennan SV, 2000, KIDNEY INT, V58, pS81, DOI 10.1046/j.1523-1755.2000.07713.x
   Mokhtar OA, 2016, ARCH CARDIOVASC DIS, V109, P445, DOI 10.1016/j.acvd.2016.04.001
   Moulias A, 2019, J CARDIOVASC PHARM T, V24, P11, DOI 10.1177/1074248418786936
   Nagase H, 2006, CARDIOVASC RES, V69, P562, DOI 10.1016/j.cardiores.2005.12.002
   Okatan EN, 2016, CAN J PHYSIOL PHARM, V94, P1064, DOI 10.1139/cjpp-2015-0531
   Okatan EN, 2015, CAN J PHYSIOL PHARM, V93, P517, DOI 10.1139/cjpp-2014-0507
   Okatan EN, 2019, MOL CELL BIOCHEM, V461, P65, DOI 10.1007/s11010-019-03590-z
   Olgar Y, 2020, MOL CELL BIOCHEM, V469, P97, DOI 10.1007/s11010-020-03731-9
   Olgar Y, 2019, CAN J PHYSIOL PHARM, V97, P528, DOI 10.1139/cjpp-2018-0466
   Olgar Y, 2018, EXP GERONTOL, V110, P172, DOI 10.1016/j.exger.2018.06.012
   Olgar Y, 2018, MOL CELL BIOCHEM, V440, P209, DOI 10.1007/s11010-017-3168-9
   Onat A, 2013, WORLD J DIABETES, V4, P210, DOI 10.4239/wjd.v4.i5.210
   Portik-Dobos V, 2002, DIABETES, V51, P3063, DOI 10.2337/diabetes.51.10.3063
   Sayar K, 2000, J NUTR, V130, P733, DOI 10.1093/jn/130.4.733
   Schnorbus B, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2014-005268
   Shapiro SD, 1998, CURR OPIN CELL BIOL, V10, P602, DOI 10.1016/S0955-0674(98)80035-5
   Sumaya Wael, 2017, Interv Cardiol Clin, V6, P49, DOI 10.1016/j.iccl.2016.08.004
   Sweeny JM, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.117.005650
   Tuncay E, 2017, DIABETES, V66, P1346, DOI 10.2337/db16-1099
   Tuncay E, 2016, BIOL TRACE ELEM RES, V169, P294, DOI 10.1007/s12011-015-0423-3
   Tuncay E, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071014
   Tuncay E, 2011, CARDIOVASC RES, V89, P634, DOI 10.1093/cvr/cvq352
   Turan B, 2000, BIOMETALS, V13, P113, DOI 10.1023/A:1009206206324
   Turan B, 2001, BIOL TRACE ELEM RES, V81, P141, DOI 10.1385/BTER:81:2:141
   Turan B, 2019, BIOL TRACE ELEM RES, V188, P160, DOI 10.1007/s12011-018-1464-1
   Turan B, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18112395
   Voulgari C, 2010, DIABETES-METAB RES, V26, P121, DOI 10.1002/dmrr.1063
   Wang XY, 2018, MICROVASC RES, V119, P98, DOI 10.1016/j.mvr.2018.05.006
   Yaras N, 2008, BRIT J PHARMACOL, V155, P1174, DOI 10.1038/bjp.2008.373
   Yaras N, 2007, J MOL CELL CARDIOL, V42, pS162, DOI 10.1016/j.yjmcc.2007.03.833
NR 53
TC 1
Z9 1
U1 0
U2 10
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD MAY
PY 2022
VL 200
IS 5
BP 2195
EP 2204
DI 10.1007/s12011-021-02816-w
EA JUL 2021
PG 10
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 0Q2UC
UT WOS:000673885100001
PM 34268701
DA 2025-06-11
ER

PT J
AU Onaolapo, AY
   Adebisi, EO
   Adeleye, AE
   Olofinnade, AT
   Onaolapo, OJ
AF Onaolapo, Adejoke Yetunde
   Adebisi, Ebenezer Oladimeji
   Adeleye, Adegbayi Emmanuel
   Olofinnade, Anthony Tope
   Onaolapo, Olakunle James
TI Dietary Melatonin Protects Against Behavioural, Metabolic, Oxidative,
   and Organ Morphological Changes in Mice that are Fed High-Fat,
   High-Sugar Diet
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Article
DE Brain; dysmetabolism; diet; neurobehaviour; melatonergic; glucose
ID BODY-WEIGHT GAIN; LIPID-PEROXIDATION; INSULIN-RESISTANCE; DAYTIME
   MELATONIN; STRESS; BRAIN; MODEL; PATHOPHYSIOLOGY; PINEALECTOMY;
   ADIPONECTIN
AB Background: Metabolic syndrome is a complex pattern of disorders that occur jointly and is associated with an increased risk of cardiovascular and cerebrovascular disease. Therefore the need for more-efficient options of treatment has become imperative.
   Objective: This study examined the effect of dietary-melatonin in the management of behavioural, metabolic, antioxidant, and organ changes due to high-fat/high-sugar (HFHS) diet-induced metabolic syndrome in mice.
   Methods: Mice were randomly assigned into five groups of ten animals each. Groups were normal control [fed standard diet (SD)], HFHS control, and 3 groups of mclatonin incorporated into HFHS at 2.5, 5, and 10 mg/kg of feed. Mice were fed for seven weeks, and body weight was assessed weekly. Open-field behaviours, radial-arm, and Y-maze spatial memory were scored at the end of the experimental period. Twenty-four hours after the last behavioural test, blood was taken for estimation of blood glucose levels after an overnight fast. Animals were then euthanised, and blood was taken for estimation of plasma insulin, leptin, and adiponectin levels, and serum lipid profile. The liver, kidneys, and brain were excised and processed for general histology, while homogenates of the liver and whole brain were used to assess oxidative stress parameters.
   Results: Results showed that dietary melatonin (compared to HFHS diet) was associated with a decrease in body weight, food intake, and novelty-induced behaviours; and an increase in spatial-working memory scores. A decrease in glucose, insulin, leptin, and malondialdehyde levels; and an increase in adiponectin levels and superoxide dismutase activity were also observed. Histomorphological/histomorphometric examination revealed evidence of organ injury with HFHS diet, and varying degrees of amelioration with melatonin-supplemented diet.
   Conclusion: In conclusion, dietary melatonin supplementation may have beneficial effects in the management of the metabolic syndrome.
C1 [Onaolapo, Adejoke Yetunde] Ladoke Akintola Univ Technol, Dept Anat, Behav Neurosci & Neurobiol Unit, Ogbomosho, Oyo State, Nigeria.
   [Onaolapo, Adejoke Yetunde; Adebisi, Ebenezer Oladimeji; Adeleye, Adegbayi Emmanuel] Ladoke Akintola Univ Technol, Dept Anat, Ogbomosho, Oyo State, Nigeria.
   [Olofinnade, Anthony Tope] Lagos State Univ, Coll Med, Fac Basic Clin Sci, Dept Pharmacol Therapeut & Toxicol, Ikeja, Lagos State, Nigeria.
   [Onaolapo, Olakunle James] Ladoke Akintola Univ Technol, Behav Neurosci & Neuropharmacol Unit, Pharmacol & Therapeut, Osogbo, Osun State, Nigeria.
C3 Lagos State University
RP Onaolapo, OJ (corresponding author), Ladoke Akintola Univ Technol, Behav Neurosci & Neuropharmacol Unit, Dept Behav Neurosci & Neuropharmacol Unit, Pharmacol & Therapeut,Fac Basic Med Sci, PMB 4400, Osogbo, Osun State, Nigeria.
EM olakunleonaolapo@yahoo.co.uk
RI Adebisi, Ebenezer/HRC-6393-2023; Onaolapo, Adejoke/HRC-4273-2023
CR Abadi SHMH, 2018, CURR MOL PHARMACOL, V11, P326, DOI 10.2174/1874467211666180830150154
   Akcay YD, 2005, CELL MOL BIOL LETT, V10, P321
   Aksoy N, 2003, CELL BIOCHEM FUNCT, V21, P121, DOI 10.1002/cbf.1006
   Altunkaynak ME, 2008, J ANAT, V212, P845, DOI 10.1111/j.1469-7580.2008.00902.x
   Aydin S, 2014, NUTRITION, V30, P1, DOI 10.1016/j.nut.2013.05.013
   Banach M, 2011, PHARMACOL REP, V63, P1
   Bibak Bahram, 2014, Adv Biomed Res, V3, P173, DOI 10.4103/2277-9175.139191
   Buettner R, 2006, J MOL ENDOCRINOL, V36, P485, DOI 10.1677/jme.1.01909
   Cardinali DP, 2013, INT J MOL SCI, V14, P2502, DOI 10.3390/ijms14022502
   Di Lorenzo C, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/782461
   DIAZ B, 1986, HORM METAB RES, V18, P225, DOI 10.1055/s-2007-1012279
   Freeman LR, 2014, NUTR NEUROSCI, V17, P241, DOI 10.1179/1476830513Y.0000000092
   Gainey SJ, 2016, FRONT BEHAV NEUROSCI, V10, DOI 10.3389/fnbeh.2016.00156
   Gatta-Cherifi B, 2015, HANDB EXP PHARMACOL, V231, P367, DOI 10.1007/978-3-319-20825-1_13
   Goyal A, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-124
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Keleher MR, 2018, J DIABETES METAB DIS, V17, P297, DOI 10.1007/s40200-018-0373-3
   Kim S, 2017, NUTRIENTS, V9, DOI 10.3390/nu9101055
   Koziróg M, 2011, J PINEAL RES, V50, P261, DOI 10.1111/j.1600-079X.2010.00835.x
   Kus I, 2004, PHYSIOL RES, V53, P403, DOI 10.33549/physiolres.930478
   Li L, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0142884
   Lim JS, 2010, NAT REV GASTRO HEPAT, V7, P251, DOI 10.1038/nrgastro.2010.41
   Lipman RD, 1998, MECH AGEING DEV, V103, P269, DOI 10.1016/S0047-6374(98)00048-7
   Lizarbe B, 2019, INT J OBESITY, V43, P1295, DOI 10.1038/s41366-018-0224-9
   Lo CC, 2017, NUTRIENTS, V9, DOI 10.3390/nu9111187
   Luengo E, 2019, J PINEAL RES, V67, DOI 10.1111/jpi.12578
   Malik VS, 2010, DIABETES CARE, V33, P2477, DOI 10.2337/dc10-1079
   Martin LJ, 2002, OBES RES, V10, P14, DOI 10.1038/oby.2002.3
   Massiera F, 2010, J LIPID RES, V51, P2352, DOI 10.1194/jlr.M006866
   Mohammadi-Sartang M, 2018, CLIN NUTR, V37, P1943, DOI 10.1016/j.clnu.2017.11.003
   Mollica A, 2017, FOOD CHEM TOXICOL, V107, P554, DOI 10.1016/j.fct.2017.03.056
   Moreno-Fernández S, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101502
   Mozaffari S, 2012, INT J PHARMACOL, V8, P496, DOI 10.3923/ijp.2012.496.509
   Onaolapo A. Y., 2018, Annals of Medical Research, V25, P518, DOI 10.5455/annalsmedres.2018.06.118
   Onaolapo AY, 2019, J CHEM NEUROANAT, V96, P22, DOI 10.1016/j.jchemneu.2018.12.002
   Onaolapo A. Y., 2011, Macedonian Journal of Medical Sciences, V4, P351
   Onaolapo AY, 2017, BIOMED PHARMACOTHER, V92, P373, DOI 10.1016/j.biopha.2017.05.094
   Onaolapo AY, 2017, N-S ARCH PHARMACOL, V390, P149, DOI 10.1007/s00210-016-1314-7
   Onaolapo OJ, 2017, BIRTH DEFECTS RES, V109, P1659, DOI 10.1002/bdr2.1171
   Onaolapo OJ, 2017, BIOMED PHARMACOTHER, V85, P323, DOI 10.1016/j.biopha.2016.11.033
   Onaolapo OJ, 2016, AIMS NEUROSCI, V3, P317, DOI 10.3934/Neuroscience.2016.3.317
   Onaolapo OJ, 2014, ANN NEUROSCI, V21, P90, DOI 10.5214/ans.0972.7531.210304
   Panchal SK, 2011, J CARDIOVASC PHARM, V57, P51, DOI [10.1097/FJC.0b013e3181feb90a, 10.1097/FJC.0b013e31821b1379]
   Prunet-Marcassus B, 2003, ENDOCRINOLOGY, V144, P5347, DOI 10.1210/en.2003-0693
   Puchalski SS, 2003, ENDOCRINE, V21, P163, DOI 10.1385/ENDO:21:2:163
   Ran DZ, 2018, BIOMED REP, V9, P221, DOI 10.3892/br.2018.1125
   Saklayen Mohammad G., 2018, CURR HYPERTENS REP, V20, DOI [10.1007/s11906-018-0812-z, DOI 10.1007/S11906-018-0812-Z]
   Salmanoglu DS, 2016, REDOX BIOL, V8, P199, DOI 10.1016/j.redox.2015.11.007
   Srinivasan V, 2013, RECENT PATENTS ENDOC, V7, P11, DOI 10.2174/187221413804660953
   Stewart LS, 2001, INT J NEUROSCI, V107, P77, DOI 10.3109/00207450109149758
   Terrón MP, 2013, PHYSIOL BEHAV, V118, P8, DOI 10.1016/j.physbeh.2013.04.006
   Tran LT, 2009, MOL CELL BIOCHEM, V332, P145, DOI 10.1007/s11010-009-0184-4
   Underwood EL, 2016, NEURAL PLAST, V2016, DOI 10.1155/2016/7385314
   Vural H, 2001, J PINEAL RES, V31, P193, DOI 10.1034/j.1600-079X.2001.310301.x
   Wang F, 2003, PHARMACOL BIOCHEM BE, V74, P573, DOI 10.1016/S0091-3057(02)01045-6
   Wang QZ, 2018, MOL NEUROBIOL, V55, P4702, DOI 10.1007/s12035-017-0663-7
   White PAS, 2013, ARQ BRAS ENDOCRINOL, V57, P339, DOI 10.1590/S0004-27302013000500002
   Yadav A, 2013, CLIN CHIM ACTA, V417, P80, DOI 10.1016/j.cca.2012.12.007
   Yamauchi T, 2001, NAT MED, V7, P941, DOI 10.1038/90984
   Yavuz O, 2003, ACTA HISTOCHEM, V105, P261, DOI 10.1078/0065-1281-00711
NR 60
TC 9
Z9 15
U1 0
U2 7
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2020
VL 20
IS 4
BP 570
EP 583
DI 10.2174/1871530319666191009161228
PG 14
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA LR3SG
UT WOS:000535612500008
PM 32138638
DA 2025-06-11
ER

PT J
AU Garg, S
   Mehndiratta, M
   Kar, R
   Malik, P
AF Garg, Seema
   Mehndiratta, Mohit
   Kar, Rajarshi
   Malik, Pranav
TI Interrelationship between nuclear factor-erythroid-2-related factor 2,
   NADPH quinone oxidoreductase and lipoprotein-associated phospholipase A2
   expression in young patients of metabolic syndrome
SO INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
LA English
DT Article
DE Metabolic syndrome; Lipoprotein-associated phospholipase A2; Nuclear
   factor E2-related factor 2; NAD(P)H quinone oxidoreductase 1
ID ABDOMINAL OBESITY; CELLULAR DEFENSE; NRF2; PATHWAY; ACTIVATION; RISK;
   A(2); DISEASE
AB Metabolic syndrome (MS) is associated with inflammation and oxidative stress (OS). Keap1/Nrf2/ARE is a cytoprotective pathway induced by OS and inflammation. This study aims to evaluate the expression of nuclear factor-erythroid-2-related factor 2 (Nrf2) and its downstream target gene NADPH quinone oxidoreductase-1 (NQO-1) in MS. Since lipoprotein-associated phospholipase A2(LpPLA2) is an important inflammatory marker believed to have a role in complications of MS, the association of its expression with that of Nrf2 and NQO-1 was also studied. Medical students (n=26) were categorised in two groups according to NCEP ATP III criteria with WHO criteria for obesity for South Asian region: patients of MS (n=13) and controls (n=13). mRNA expression of Nrf2, NQO-1 and LpPLA2 genes was evaluated by qPCR in blood using specific primers. Fold change was calculated by 2(-cT) method keeping -actin as internal control. Expression of NQO-1 and LpPLA2 was found to be higher in MS. However, Nrf2 expression was low in patients who had hypertriglyceridemia when compared with patients with normal triglyceride levels. A significant correlation was observed in expression of LpPLA2, with Nrf2 and NQO-1. Our data suggests that there may be compensatory activation of antioxidant defence mechanism in young patients of MS. Further evidence is provided by higher expression of LpPLA2 and its correlation with Nrf2 and NQO-1 in MS which suggests that inflammatory stress may induce expression of genes of cytoprotective pathways. Additionally, this study, for the first time, indicates that Nrf2 may have some role in regulating triglyceride (TG) concentration.
C1 [Garg, Seema; Mehndiratta, Mohit; Kar, Rajarshi] Univ Delhi, Univ Coll Med Sci, Dept Biochem, Delhi 110095, India.
   [Garg, Seema; Mehndiratta, Mohit; Kar, Rajarshi; Malik, Pranav] Univ Delhi, GTB Hosp, Delhi 110095, India.
   [Malik, Pranav] Univ Delhi, Univ Coll Med Sci, Delhi, India.
C3 University of Delhi; University College of Medical Sciences; University
   of Delhi; University College of Medical Sciences; University of Delhi;
   University College of Medical Sciences
RP Garg, S (corresponding author), Univ Delhi, Univ Coll Med Sci, Dept Biochem, Delhi 110095, India.; Garg, S (corresponding author), Univ Delhi, GTB Hosp, Delhi 110095, India.
EM seegarg@yahoo.com
FU Indian Council of Medical Research, New Delhi [2014-04698]
FX The study was conducted under the Short Term Studentship program
   (reference ID: 2014-04698) of Indian Council of Medical Research, New
   Delhi.
CR [Anonymous], 2000, ASIA PACIFIC PERSPEC
   Aronne LJ, 2007, AM J MED, V120, pS29, DOI 10.1016/j.amjmed.2006.11.015
   Bergman RN, 2007, AM J MED, V120, pS3, DOI 10.1016/j.amjmed.2006.11.012
   Chandey M., 2017, Int J Adv Med, V4, P463, DOI [10.18203/2349-3933.ijam20171042, DOI 10.18203/2349-3933.IJAM20171042]
   Chartoumpekis DV, 2013, CURR DIABETES REV, V9, P137, DOI 10.2174/1573399811309020005
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Das SK, 2011, J CLIN ENDOCR METAB, V96, pE1308, DOI 10.1210/jc.2011-0101
   Dinkova-Kostova AT, 2010, ARCH BIOCHEM BIOPHYS, V501, P116, DOI 10.1016/j.abb.2010.03.019
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Garg S, 2016, DIABETES METAB SYND, V10, pS21, DOI 10.1016/j.dsx.2015.09.003
   Gong HP, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-13
   Hatoum IJ, 2010, AM J CLIN NUTR, V91, P786, DOI 10.3945/ajcn.2009.28870
   Hwang JH, 2009, DIABETES, V58, P965, DOI 10.2337/db08-1183
   Jain Sharad R., 2015, International Journal of Chronic Diseases
   Kitteringham NR, 2010, J PROTEOMICS, V73, P1612, DOI 10.1016/j.jprot.2010.03.018
   Lee JM, 2005, FASEB J, V19, P1061, DOI 10.1096/fj.04-2591hyp
   Lee JM, 2004, J BIOCHEM MOL BIOL, V37, P139
   Li WG, 2008, BIOCHEM PHARMACOL, V76, P1485, DOI 10.1016/j.bcp.2008.07.017
   Madjid M, 2010, TEX HEART I J, V37, P25
   Marseglia L, 2015, INT J MOL SCI, V16, P378, DOI 10.3390/ijms16010378
   Motohashi H, 2004, TRENDS MOL MED, V10, P549, DOI 10.1016/j.molmed.2004.09.003
   Mutter FE, 2015, BIOCHEM SOC T, V43, P657, DOI 10.1042/BST20150044
   Persson M, 2007, ARTERIOSCL THROM VAS, V27, P1411, DOI 10.1161/ATVBAHA.107.142679
   Pi JB, 2010, J BIOL CHEM, V285, P9292, DOI 10.1074/jbc.M109.093955
   Riedmaier I, 2013, METHODS, V59, P3, DOI 10.1016/j.ymeth.2012.08.012
   Santillán LD, 2013, METAB SYNDR RELAT D, V11, P359, DOI 10.1089/met.2012.0155
   Sugimoto H, 2010, AM J PHYSIOL-GASTR L, V298, pG283, DOI 10.1152/ajpgi.00296.2009
   Suzuki T, 2015, FREE RADICAL BIO MED, V88, P93, DOI 10.1016/j.freeradbiomed.2015.06.006
   Sykiotis GP, 2011, CURR OPIN CLIN NUTR, V14, P41, DOI 10.1097/MCO.0b013e32834136f2
   Tselepis AD, 2002, ATHEROSCLEROSIS SUPP, V3, P57, DOI 10.1016/S1567-5688(02)00045-4
   Wang WY, 2010, CARDIOVASC RES, V85, P845, DOI 10.1093/cvr/cvp367
   WHO, WHO STEPS MAN
   Yates MS, 2009, CARCINOGENESIS, V30, P1024, DOI 10.1093/carcin/bgp100
   Zhang YKJ, 2010, TOXICOL APPL PHARM, V245, P326, DOI 10.1016/j.taap.2010.03.016
NR 34
TC 0
Z9 0
U1 0
U2 4
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0973-3930
EI 1998-3832
J9 INT J DIABETES DEV C
JI Int. Diabetes Dev. Ctries.
PD JAN
PY 2019
VL 39
IS 1
BP 74
EP 81
DI 10.1007/s13410-018-0653-y
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HQ8CO
UT WOS:000462651700012
DA 2025-06-11
ER

PT J
AU Meegaswatte, H
   Speer, K
   Mckune, AJ
   Naumovski, N
AF Meegaswatte, Harshini
   Speer, Kathryn
   Mckune, Andrew J.
   Naumovski, Nenad
TI Functional Foods and Nutraceuticals for the Management of Cardiovascular
   Disease Risk in Postmenopausal Women
SO REVIEWS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE cardiovascular disease; menopause; postmenopausal women; metabolic
   syndrome; vascular health; functional foods; nutraceuticals
ID VASCULAR ENDOTHELIAL FUNCTION; N-ACETYLCYSTEINE; OXIDATIVE STRESS;
   L-THEANINE; ARTERIAL STIFFNESS; BODY-COMPOSITION; INSULIN SENSITIVITY;
   METABOLIC SYNDROME; DOUBLE-BLIND; PHYTOESTROGEN SUPPLEMENTATION
AB Cardiovascular disease (CVD) is a leading cause of death in women and risk of development is greatly increased following menopause. Menopause occurs over several years and is associated with hormonal changes, including a reduction in estradiol and an increase in follicle-stimulating hormone. This hormonal shift may result in an increased risk of developing abdominal adiposity, insulin resistance, dyslipidemia, vascular dysfunction, hypertension, type 2 diabetes mellitus (T2DM), metabolic dysfunction-associated fatty liver disease (MAFLD), and metabolic syndrome (MetS). Furthermore, with the onset of menopause, there is an increase in oxidative stress that is associated with impaired vascular function, inflammation, and thrombosis, further increasing the risk of CVD development. Despite the harmful consequences of the menopause transition being well known, women in premenopausal, perimenopausal, and postmenopausal stages are unlikely to be enrolled in research studies. Therefore, investigations on the prevention and treatment of cardiovascular and metabolic disease in middle-aged women are still relatively limited. Whilst lifestyle interventions are associated with reduced CVD risk in this population sample, the evidence still remains inconclusive. Therefore, it is important to explore the effectiveness of early intervention and potential therapeutic approaches to maintain cellular redox balance, preserve endothelium, and reduce inflammation. Glycine, N-acetylcysteine, and L-theanine are amino acids with potential antioxidant and anti-inflammatory activity and are identified as therapeutic interventions in the management of age-related and metabolic diseases. The benefits of the intake of these amino acids for improving factors associated with cardiovascular health are discussed in this review. Future studies using these amino acids are warranted to investigate their effect on maintaining the vascular health and cardiovascular outcomes of postmenopausal women.
C1 [Meegaswatte, Harshini; Speer, Kathryn; Mckune, Andrew J.; Naumovski, Nenad] Univ Canberra, Fac Hlth, Canberra, ACT 2617, Australia.
   [Meegaswatte, Harshini; Speer, Kathryn; Mckune, Andrew J.; Naumovski, Nenad] Univ Canberra, Funct Foods & Nutr Res FFNR Lab, Canberra, ACT 2617, Australia.
   [Meegaswatte, Harshini; Speer, Kathryn; Mckune, Andrew J.; Naumovski, Nenad] Univ Canberra, Univ Canberra Res Inst Sport & Exercise UCRISE, Canberra, ACT 2617, Australia.
   [Mckune, Andrew J.] Univ KwaZulu Natal, Sch Hlth Sci, Discipline Biokinet Exercise & Leisure Sci, ZA-4041 Durban, South Africa.
   [Naumovski, Nenad] Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens 17676, Greece.
C3 University of Canberra; University of Canberra; University of Canberra;
   University of Kwazulu Natal; Harokopio University Athens
RP Naumovski, N (corresponding author), Univ Canberra, Fac Hlth, Canberra, ACT 2617, Australia.; Naumovski, N (corresponding author), Univ Canberra, Funct Foods & Nutr Res FFNR Lab, Canberra, ACT 2617, Australia.; Naumovski, N (corresponding author), Univ Canberra, Univ Canberra Res Inst Sport & Exercise UCRISE, Canberra, ACT 2617, Australia.; Naumovski, N (corresponding author), Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens 17676, Greece.
EM nenad.naumovski@canberra.edu.au
RI McKune, Andrew/AAM-3086-2020; Naumovski, Nenad/O-5617-2015
CR Abshirini M, 2020, MENOPAUSE, V27, P1425, DOI 10.1097/GME.0000000000001622
   Abshirini M, 2018, NUTRITION, V55-56, P161, DOI 10.1016/j.nut.2018.04.014
   Akazawa N, 2012, NUTR RES, V32, P795, DOI 10.1016/j.nutres.2012.09.002
   Aldini G, 2018, FREE RADICAL RES, V52, P751, DOI 10.1080/10715762.2018.1468564
   AlGhatrif M, 2013, HYPERTENSION, V62, P934, DOI 10.1161/HYPERTENSIONAHA.113.01445
   Dias RCA, 2019, INT J RHEUM DIS, V22, P1961, DOI 10.1111/1756-185X.13713
   Alves A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061356
   Amiri M, 2022, MATURITAS, V155, P40, DOI 10.1016/j.maturitas.2021.10.001
   Arakawa M, 2007, CEREBELLUM, V6, P308, DOI 10.1080/14734220601142878
   Arranz L, 2008, FREE RADICAL BIO MED, V45, P1252, DOI 10.1016/j.freeradbiomed.2008.07.014
   Berry C, 2002, QJM-INT J MED, V95, P639, DOI 10.1093/qjmed/95.9.639
   Berstein L. M., 2012, Voprosy Onkologii (St. Petersburg), V58, P45
   Bi WK, 2020, ACTA PHARMACOL SIN, V41, P1033, DOI 10.1038/s41401-020-0384-8
   Bromberger JT, 2011, PSYCHOL MED, V41, P1879, DOI 10.1017/S003329171100016X
   Bruns CM, 2004, ILAR J, V45, P160, DOI 10.1093/ilar.45.2.160
   Bulman A, 2021, BEVERAGES, V7, DOI 10.3390/beverages7020033
   Byun JS, 2010, INT J VITAM NUTR RES, V80, P97, DOI 10.1024/0300-9831/a000010
   Camfield DA, 2014, NUTR REV, V72, P507, DOI 10.1111/nure.12120
   Catania MA, 2002, PLANTA MED, V68, P1142, DOI 10.1055/s-2002-36349
   Cieslik KA, 2018, J GERONTOL A-BIOL, V73, P1167, DOI 10.1093/gerona/gly034
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Connelly PJ, 2022, J HUM HYPERTENS, V36, P120, DOI 10.1038/s41371-021-00576-7
   Cruz M, 2008, J ENDOCRINOL INVEST, V31, P694, DOI 10.1007/BF03346417
   Nguyen D, 2014, J CLIN ENDOCR METAB, V99, P169, DOI 10.1210/jc.2013-2376
   Davinelli S, 2017, MATURITAS, V96, P77, DOI 10.1016/j.maturitas.2016.11.016
   Davis SR, 2015, NAT REV DIS PRIMERS, V1, DOI 10.1038/nrdp.2015.4
   Delgobo M, 2019, J NUTR BIOCHEM, V67, P190, DOI 10.1016/j.jnutbio.2019.02.012
   Díaz-Flores M, 2013, CAN J PHYSIOL PHARM, V91, P855, DOI 10.1139/cjpp-2012-0341
   Dodd S, 2008, EXPERT OPIN BIOL TH, V8, P1955, DOI [10.1517/14728220802517901, 10.1517/14728220802517901 ]
   Duckles SP, 2010, PFLUG ARCH EUR J PHY, V459, P841, DOI 10.1007/s00424-010-0797-1
   El Khoudary SR, 2020, CIRCULATION, V142, pe506, DOI 10.1161/CIR.0000000000000912
   El Khoudary SR, 2016, J CLIN LIPIDOL, V10, P962, DOI 10.1016/j.jacl.2016.04.008
   Eslam M, 2020, J HEPATOL, V73, P202, DOI 10.1016/j.jhep.2020.03.039
   Eslam M, 2020, GASTROENTEROLOGY, V158, P1999, DOI 10.1053/j.gastro.2019.11.312
   Espeland MA, 1997, J CLIN ENDOCR METAB, V82, P1549, DOI 10.1210/jc.82.5.1549
   Ferreira LF, 2011, INT J SPORT NUTR EXE, V21, P146, DOI 10.1123/ijsnem.21.2.146
   Figueroa A, 2023, NUTRIENTS, V15, DOI 10.3390/nu15071557
   Gannon MC, 2002, AM J CLIN NUTR, V76, P1302, DOI 10.1093/ajcn/76.6.1302
   Giardina S, 2010, Minerva Ginecol, V62, P195
   Gladwin MT, 2012, NATURE, V491, P344, DOI 10.1038/nature11640
   Glisic M, 2018, MATURITAS, V115, P74, DOI 10.1016/j.maturitas.2018.06.012
   Green DJ, 2016, EXP PHYSIOL, V101, P230, DOI 10.1113/EP085367
   Greendale GA, 2019, JCI INSIGHT, V4, DOI 10.1172/jci.insight.124865
   Harlow SD, 2012, J CLIN ENDOCR METAB, V97, P1159, DOI 10.1210/jc.2011-3362
   Harvey A, 2015, J MOL CELL CARDIOL, V83, P112, DOI 10.1016/j.yjmcc.2015.04.011
   Heard K, 2010, CLIN TOXICOL, V48, P424, DOI 10.3109/15563650.2010.486381
   Hidese S., 2019, NUTRIENTS, V11, DOI DOI 10.3390/nu11102362
   HOLDINESS MR, 1991, CLIN PHARMACOKINET, V20, P123, DOI 10.2165/00003088-199120020-00004
   Hulteen RM, 2023, INT J SPORTS MED, V44, P389, DOI 10.1055/a-2003-9406
   Irace C, 2013, EUR J CLIN INVEST, V43, P1025, DOI 10.1111/eci.12139
   JACKSON AA, 1987, BRIT J NUTR, V58, P207, DOI 10.1079/BJN19870088
   Janssen I, 2008, ARCH INTERN MED, V168, P1568, DOI 10.1001/archinte.168.14.1568
   Janssen I, 2015, OBESITY, V23, P488, DOI 10.1002/oby.20974
   Jehan S., 2015, J. Sleep Disord.Ther, V4, P212, DOI DOI 10.4172/2167-0277.1000212
   Jeong HG, 2022, METABOLITES, V12, DOI 10.3390/metabo12100954
   Kang YJ, 2023, NUTRIENTS, V15, DOI 10.3390/nu15010074
   KANNEL WB, 1976, ANN INTERN MED, V85, P447, DOI 10.7326/0003-4819-85-4-447
   Kaur S, 2011, FOOD SCI BIOTECHNOL, V20, P861, DOI 10.1007/s10068-011-0121-7
   Khanam MA, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020259
   Knapen MHJ, 2015, THROMB HAEMOSTASIS, V113, P1135, DOI 10.1160/TH14-08-0675
   Kondo K, 2014, METABOLISM, V63, P930, DOI 10.1016/j.metabol.2014.04.005
   Kravitz HM, 2003, MENOPAUSE, V10, P19, DOI 10.1097/01.GME.0000030707.35686.5A
   Kravitz HM, 2018, OBSTET GYN CLIN N AM, V45, P679, DOI 10.1016/j.ogc.2018.07.008
   Kravitz HM, 2011, OBSTET GYN CLIN N AM, V38, P567, DOI 10.1016/j.ogc.2011.06.002
   Kumar P, 2023, J GERONTOL A-BIOL, V78, P75, DOI 10.1093/gerona/glac135
   Kumar P, 2022, NUTRIENTS, V14, DOI 10.3390/nu14051114
   Kumar P, 2021, CLIN TRANSL MED, V11, DOI 10.1002/ctm2.372
   Kumar P, 2020, BIOMEDICINES, V8, DOI 10.3390/biomedicines8100390
   Lakatta EG, 2003, CIRCULATION, V107, P139, DOI 10.1161/01.CIR.0000048892.83521.58
   Landgren BM, 2004, J CLIN ENDOCR METAB, V89, P2763, DOI 10.1210/jc.2003-030824
   Li S, 2015, INT J MOL SCI, V16, P26087, DOI 10.3390/ijms161125942
   Li T, 2023, ANN PALLIAT MED, DOI 10.21037/apm-22-1395
   Lindberg E, 2020, SLEEP MED REV, V49, DOI 10.1016/j.smrv.2019.101225
   Lionetti V, 2019, EUR HEART J, V40, P575, DOI 10.1093/eurheartj/ehy597
   Liu ZM, 2015, MENOPAUSE, V22, P496, DOI [10.1097/GME.0000000000000349, 10.1097/gme.0000000000000349]
   Lizcano F, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/757461
   Lizzo G, 2022, FRONT AGING-LAUSANNE, V3, DOI 10.3389/fragi.2022.852569
   Lovejoy JC, 2008, INT J OBESITY, V32, P949, DOI 10.1038/ijo.2008.25
   Lyon MR, 2011, ALTERN MED REV, V16, P348
   Maharaj A, 2022, NUTRIENTS, V14, DOI 10.3390/nu14204396
   Makkar R, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21124424
   Maritim AC, 2003, J BIOCHEM MOL TOXIC, V17, P24, DOI 10.1002/jbt.10058
   Marlatt KL, 2022, OBESITY, V30, P14, DOI 10.1002/oby.23289
   Marlatt KL, 2020, AM J OBSTET GYNECOL, V222, DOI 10.1016/j.ajog.2019.09.051
   Martin SS, 2024, CIRCULATION, V149, pE347, DOI 10.1161/CIR.0000000000001209
   Mauvais-Jarvis F, 2017, ENDOCR REV, V38, P173, DOI 10.1210/er.2016-1146
   Meléndez-Hevia E, 2009, J BIOSCIENCES, V34, P853, DOI 10.1007/s12038-009-0100-9
   Meng WT, 2024, J NANOBIOTECHNOL, V22, DOI 10.1186/s12951-024-02631-0
   Monteleone P, 2018, NAT REV ENDOCRINOL, V14, P199, DOI 10.1038/nrendo.2017.180
   Moradi M, 2020, CRIT REV FOOD SCI, V60, P3414, DOI 10.1080/10408398.2019.1689097
   Moreau KL, 2020, GEROSCIENCE, V42, P1699, DOI 10.1007/s11357-020-00236-7
   Moreau KL, 2013, J CLIN ENDOCR METAB, V98, P4507, DOI 10.1210/jc.2013-2183
   Moreau KL, 2012, J CLIN ENDOCR METAB, V97, P4692, DOI 10.1210/jc.2012-2244
   Moskalev A, 2015, AGING-US, V7, P616, DOI 10.18632/aging.100799
   Hermoso DAM, 2016, LIFE SCI, V157, P178, DOI 10.1016/j.lfs.2016.05.044
   Muthusami S, 2005, CLIN CHIM ACTA, V360, P81, DOI 10.1016/j.cccn.2005.04.014
   Nair AR, 2021, CURR CARDIOL REV, V17, DOI 10.2174/1573403X16666201106141811
   Nemes R, 2018, ANTIOXIDANTS-BASEL, V7, DOI 10.3390/antiox7070085
   Noll PRES, 2021, CLIMACTERIC, V24, P128, DOI 10.1080/13697137.2020.1828854
   Papini G, 2023, J TRANSL MED, V21, DOI 10.1186/s12967-023-04155-x
   Peila R, 2023, J AM HEART ASSOC, V12, DOI 10.1161/JAHA.122.029111
   Pengo MF, 2018, CHEST, V154, P196, DOI 10.1016/j.chest.2018.04.005
   Pérez-Torres I, 2020, MOLECULES, V25, DOI 10.3390/molecules25112555
   Potter B, 2018, PRIMARY CARE, V45, P625, DOI 10.1016/j.pop.2018.08.001
   Rao TP, 2015, J AM COLL NUTR, V34, P436, DOI 10.1080/07315724.2014.926153
   Ravyts SG, 2024, CLIN GERONTOLOGIST, V47, P367, DOI 10.1080/07317115.2022.2064789
   Rivero-Pino F, 2024, FOOD CHEM, V457, DOI 10.1016/j.foodchem.2024.140168
   Roberts H, 2016, MATURITAS, V86, P53, DOI 10.1016/j.maturitas.2016.01.007
   Robeva R, 2021, MATURITAS, V151, P22, DOI 10.1016/j.maturitas.2021.06.012
   Rogers PJ, 2008, PSYCHOPHARMACOLOGY, V195, P569, DOI 10.1007/s00213-007-0938-1
   Rossi R, 2008, J AM COLL CARDIOL, V51, P997, DOI 10.1016/j.jacc.2007.11.044
   Rushworth GF, 2014, PHARMACOL THERAPEUT, V141, P150, DOI 10.1016/j.pharmthera.2013.09.006
   Sakamoto FL, 2019, PHARMACOL RES, V147, DOI 10.1016/j.phrs.2019.104395
   Samavat H, 2016, AM J CLIN NUTR, V104, P1671, DOI 10.3945/ajcn.116.137075
   Sanders KM, 2007, TRANSL RES, V150, P215, DOI 10.1016/j.trsl.2007.03.012
   Sankar P, 2015, EXP GERONTOL, V63, P67, DOI 10.1016/j.exger.2015.02.001
   Sarris J, 2019, J PSYCHIATR RES, V110, P31, DOI 10.1016/j.jpsychires.2018.12.014
   Schüller AK, 2018, PHARMACOL REP, V70, P263, DOI 10.1016/j.pharep.2017.10.006
   Sekhar RV, 2021, J NUTR, V151, P3606, DOI 10.1093/jn/nxab309
   Sekhar RV, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11010154
   Sekhar RV, 2011, AM J CLIN NUTR, V94, P847, DOI 10.3945/ajcn.110.003483
   Sergi D, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00532
   Shahripour RB, 2014, BRAIN BEHAV, V4, P108, DOI 10.1002/brb3.208
   Shi YC, 2022, SIGNAL TRANSDUCT TAR, V7, DOI 10.1038/s41392-022-01055-2
   Soh J, 2024, GEROSCIENCE, V46, P219, DOI 10.1007/s11357-023-00970-8
   Soleymani M, 2019, MENOPAUSE, V26, P365, DOI 10.1097/GME.0000000000001245
   Somani YB, 2022, APPL PHYSIOL NUTR ME, V47, P749, DOI 10.1139/apnm-2021-0693
   Speer H, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10081247
   Stachowiak G, 2015, MENOPAUSE REV, V14, P59, DOI 10.5114/pm.2015.50000
   Stefanska A, 2015, ADV CLIN CHEM, V72, P1, DOI 10.1016/bs.acc.2015.07.001
   Sudoh N, 2001, CIRCULATION, V103, P724
   Tardiolo G, 2018, MOLECULES, V23, DOI 10.3390/molecules23123305
   Tenório MCD, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10060967
   Thurston RC, 2018, CLIMACTERIC, V21, P96, DOI 10.1080/13697137.2018.1430131
   Tomiyama H, 2018, INT J CARDIOL, V253, P161, DOI 10.1016/j.ijcard.2017.11.022
   Toth MJ, 2000, ANN NY ACAD SCI, V904, P502
   Türközü D, 2017, CRIT REV FOOD SCI, V57, P1681, DOI 10.1080/10408398.2015.1016141
   Vallance P, 2001, HEART, V85, P342, DOI 10.1136/heart.85.3.342
   Virani SS, 2021, CIRCULATION, V143, pe254, DOI 10.1161/CIR.0000000000000950
   Vogel B, 2021, LANCET, V397, P2385, DOI 10.1016/S0140-6736(21)00684-X
   Vona R, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8267234
   Vuong QV, 2011, J SCI FOOD AGR, V91, P1931, DOI 10.1002/jsfa.4373
   WALTON C, 1993, EUR J CLIN INVEST, V23, P466, DOI 10.1111/j.1365-2362.1993.tb00792.x
   Wang WW, 2013, AMINO ACIDS, V45, P463, DOI 10.1007/s00726-013-1493-1
   Whitton K, 2024, Clinical Endocrinology & Metabolism, V38
   Williams J, 2020, FOODS, V9, DOI 10.3390/foods9030371
   Williams J, 2019, PHYTOTHER RES, V33, P571, DOI 10.1002/ptr.6277
   Williams J, 2016, BEVERAGES, V2, DOI 10.3390/beverages2020013
   Williams JL, 2020, PLANT FOOD HUM NUTR, V75, P12, DOI 10.1007/s11130-019-00771-5
   Wolters M, 2020, MENOPAUSE, V27, P1081, DOI 10.1097/GME.0000000000001566
   Yu E, 2018, J AM COLL CARDIOL, V72, P914, DOI 10.1016/j.jacc.2018.02.085
   Zhou Y, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-01489-7
   Zuo H, 2009, METABOLISM, V58, P1102, DOI 10.1016/j.metabol.2009.04.008
NR 153
TC 1
Z9 1
U1 4
U2 4
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 1530-6550
EI 2153-8174
J9 REV CARDIOVASC MED
JI Rev. Cardiovasc. Med.
PD DEC 25
PY 2024
VL 25
IS 12
AR 460
DI 10.31083/j.rcm2512460
PG 15
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA Q6Y7N
UT WOS:001386114000001
PM 39742223
OA gold
DA 2025-06-11
ER

PT J
AU Georgoulis, M
   Kontogianni, MD
   Kechribari, I
   Tenta, R
   Fragopoulou, E
   Lamprou, K
   Perraki, E
   Vagiakis, E
   Yiannakouris, N
AF Georgoulis, Michael
   Kontogianni, Meropi D.
   Kechribari, Ioanna
   Tenta, Roxane
   Fragopoulou, Elizabeth
   Lamprou, Kallirroi
   Perraki, Eleni
   Vagiakis, Emmanouil
   Yiannakouris, Nikos
TI Associations between serum vitamin D status and the cardiometabolic
   profile of patients with obstructive sleep apnea
SO HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE Sleep apnea; 25-Hydroxyvitamin D; Vitamin D deficiency; Metabolic
   syndrome; Obesity; Insulin resistance; Inflammation; Oxidative stress
ID METABOLIC SYNDROME; D SUPPLEMENTATION; D DEFICIENCY; ADULTS; PREVALENCE;
   ACCURACY; GLUCOSE; PLASMA
AB Purpose Obstructive sleep apnea (OSA) and the metabolic syndrome (MetS) frequently coexist. Low serum vitamin D has been positively associated with OSA presence and severity; however, data on its link to cardiometabolic features in patients with OSA remain scarce. We aimed to assess serum 25-hydroxyvitamin D [25(OH)D] and explore its association with cardiometabolic parameters in OSA.
   Methods This was a cross-sectional study among 262 patients (49 +/- 9 years old, 73% men) with polysomnography-diagnosed OSA. Participants were evaluated in terms of anthropometric indices, lifestyle habits, blood pressure, biochemical, plasma inflammatory and urinary oxidative stress markers, and the presence of MetS. Serum 25(OH)D was assessed by chemiluminescence, and vitamin D deficiency (VDD) was defined as 25(OH)D < 20 ng/mL.
   Results Median (1(st), 3(rd) quartile) serum 25(OH)D levels were 17.7 (13.4, 22.9) ng/mL and 63% of participants had VDD. Serum 25(OH)D correlated negatively with body mass index (BMI), homeostasis model of assessment of insulin resistance (HOMA-IR), total cholesterol, low-density lipoprotein cholesterol, triglycerides, high-sensitivity C-reactive protein (hsCRP), and urinary oxidized guanine species (oxG), and positively with high-density lipoprotein cholesterol (all P < 0.050). In logistic regression analysis, serum 25(OH)D was associated with lower odds of MetS [odds ratio (95% confidence interval): 0.94 (0.90-0.98)], after adjustment for age, sex, season of blood sampling, Mediterranean diet score, physical activity, smoking, apnea-hypopnea index, HOMA-IR, hsCRP, and oxG. In the same multivariate model, VDD was associated with similar to two fold greater odds of MetS [2.39 (1.15, 4.97)].
   Conclusion VDD is highly prevalent and is associated with a detrimental cardiometabolic profile among patients with OSA.
C1 [Georgoulis, Michael; Kontogianni, Meropi D.; Kechribari, Ioanna; Tenta, Roxane; Fragopoulou, Elizabeth; Yiannakouris, Nikos] Harokopio Univ Athens, Sch Hlth Sci & Educ, Dept Nutr & Dietet, 70 El Venizelou Str, Athens 17676, Greece.
   [Lamprou, Kallirroi; Perraki, Eleni; Vagiakis, Emmanouil] Natl & Kapodistrian Univ Athens, Evangelismos Gen Hosp, Ctr Sleep Disorders, Dept Crit Care & Pulm Serv 1,Med Sch, Athens 10676, Greece.
C3 Harokopio University Athens; National & Kapodistrian University of
   Athens; Evangelismos Hospital
RP Yiannakouris, N (corresponding author), Harokopio Univ Athens, Sch Hlth Sci & Educ, Dept Nutr & Dietet, 70 El Venizelou Str, Athens 17676, Greece.
EM nyiannak@hua.gr
RI Kontogianni, Meropi/AAN-6530-2021; YIANNAKOURIS, NIKOS/AAL-7123-2021;
   Tenta, Roxane/AAM-9669-2021; Georgoulis, Michael/AAO-2167-2021
OI Yiannakouris, Nikos/0000-0003-3269-4919; Georgoulis,
   Michael/0000-0003-4619-2100
CR Abbasi A, 2021, SLEEP SCI, V14, P142, DOI 10.5935/1984-0063.20200056
   Ainsworth BE, 2011, MED SCI SPORT EXER, V43, P1575, DOI 10.1249/MSS.0b013e31821ece12
   Amrein K, 2020, EUR J CLIN NUTR, V74, P1498, DOI 10.1038/s41430-020-0558-y
   [Anonymous], 2000, JAMA, V284, P3043
   [Anonymous], 1999, Archives of Hellenic Medicine, V16, P516
   Archontogeorgis K, 2019, MEDICINA-LITHUANIA, V55, DOI 10.3390/medicina55050174
   Ayyildiz F, 2021, TURK J MED SCI, V51, P2524, DOI 10.3906/sag-2101-83
   Bahadorpour S, 2022, NUTR REV, V81, P1, DOI 10.1093/nutrit/nuac038
   Barbarawi M, 2019, JAMA CARDIOL, V4, P765, DOI 10.1001/jamacardio.2019.1870
   Barceló A, 2013, RESPIRATION, V86, P295, DOI 10.1159/000342748
   Berry RB, 2015, J CLIN SLEEP MED, V11, P1253, DOI 10.5664/jcsm.5176
   Bountziouka V, 2012, NUTR METAB CARDIOVAS, V22, P659, DOI 10.1016/j.numecd.2010.10.015
   Bozkurt NC, 2012, ENDOCRINE, V41, P518, DOI 10.1007/s12020-012-9595-1
   Cannell JJ, 2014, DERM-ENDOCRINOL, V6, DOI 10.4161/19381980.2014.983401
   Christakos S, 2016, PHYSIOL REV, V96, P365, DOI 10.1152/physrev.00014.2015
   Coughlin S, 2001, Obes Rev, V2, P267, DOI 10.1046/j.1467-789X.2001.00045.x
   Dimakopoulos I, 2020, NUTRITION, V72, DOI 10.1016/j.nut.2019.110641
   Dimakopoulos I, 2019, CLIN NUTR ESPEN, V34, P23, DOI 10.1016/j.clnesp.2019.09.008
   FRIEDEWALD WT, 1972, CLIN CHEM, V18
   Georgoulis M, 2021, EUR J NUTR, V60, P3799, DOI 10.1007/s00394-021-02552-w
   Georgoulis M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061570
   Graille M, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21113743
   Guillot X, 2010, JOINT BONE SPINE, V77, P552, DOI 10.1016/j.jbspin.2010.09.018
   Holick Michael F, 2011, J Clin Endocrinol Metab, V96, P1911, DOI 10.1210/jc.2011-0385
   Hollis BW, 2008, CURR OPIN ENDOCRINOL, V15, P489, DOI 10.1097/MED.0b013e328317ca6c
   Jonnalagadda SS, 2000, J AM DIET ASSOC, V100, P303, DOI 10.1016/S0002-8223(00)00095-X
   Karampela I, 2021, CURR OBES REP, V10, P162, DOI 10.1007/s13679-021-00433-1
   Kechribari I, 2022, J HUM NUTR DIET, V35, P948, DOI 10.1111/jhn.12933
   Kechribari I, 2022, SLEEP BREATH, V26, P89, DOI 10.1007/s11325-021-02351-x
   Kechribari I, 2020, J ACAD NUTR DIET, V120, P1042, DOI 10.1016/j.jand.2019.10.016
   Kerley CP, 2017, J CLIN SLEEP MED, V13, P19, DOI 10.5664/jcsm.6378
   Léger D, 2020, SLEEP MED REV, V51, DOI 10.1016/j.smrv.2020.101275
   Li XY, 2020, RESP RES, V21, DOI 10.1186/s12931-020-01554-2
   Magriplis E., 2016, Clinical Nutrition ESPEN, V13, pe70, DOI 10.1016/j.clnesp.2016.03.064
   Manios Y, 2018, EUR J NUTR, V57, P2001, DOI 10.1007/s00394-017-1564-2
   Manios Y, 2017, BRIT J NUTR, V118, P550, DOI [10.1017/s0007114517002422, 10.1017/S0007114517002422]
   Marquina C, 2019, OBES REV, V20, P262, DOI 10.1111/obr.12793
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mirhosseini N, 2018, FRONT CARDIOVASC MED, V5, DOI 10.3389/fcvm.2018.00087
   Mithal A, 2009, OSTEOPOROSIS INT, V20, P1807, DOI 10.1007/s00198-009-0954-6
   Nilsson PM, 2019, EUR J PREV CARDIOL, V26, P33, DOI 10.1177/2047487319886404
   Panagiotakos DB, 2007, PREV MED, V44, P335, DOI 10.1016/j.ypmed.2006.12.009
   Papaioannou I, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.9657
   Papathanasiou G, 2010, EUR J CARDIOV PREV R, V17, P380, DOI 10.1097/HJR.0b013e328333ede6
   Pei YY, 2022, NUTRIENTS, V14, DOI 10.3390/nu14153158
   Piepoli MF, 2016, ATHEROSCLEROSIS, V252, P207, DOI [10.1016/j.atherosclerosis.2016.05.037, 10.1177/2047487316653709]
   Radkhah N, 2021, J CARDIOVASC THORAC, V13, P190, DOI 10.34172/jcvtr.2021.21
   Randerath W, 2018, EUR RESPIR J, V52, DOI 10.1183/13993003.02616-2017
   Shantavasinkul PC, 2022, NUTRIENTS, V14, DOI 10.3390/nu14153075
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Somers VK, 2008, J AM COLL CARDIOL, V52, P686, DOI 10.1016/j.jacc.2008.05.002
   Verrusio W, 2017, ANN I SUPER SANITA, V53, P54, DOI 10.4415/ANN_17_01_11
   Vgontzas AN, 2016, J PHYSIOL-LONDON, V594, P4687, DOI 10.1113/JP272114
   Warren T, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10082007
   Yeghiazarians Y, 2021, CIRCULATION, V144, pE56, DOI 10.1161/CIR.0000000000000988
NR 55
TC 6
Z9 6
U1 0
U2 6
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1109-3099
EI 2520-8721
J9 HORM-INT J ENDOCRINO
JI Horm.-Int. J. Endocrinol. Metab.
PD SEP
PY 2023
VL 22
IS 3
BP 477
EP 490
DI 10.1007/s42000-023-00456-4
EA JUN 2023
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HY2Q3
UT WOS:001007770500001
PM 37322405
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Mitjavila, MT
   Fandos, M
   Salas-Salvadó, J
   Covas, MI
   Borrego, S
   Estruch, R
   Lamuela-Raventós, R
   Corella, D
   Martínez-Gonzalez, MA
   Sánchez, JM
   Bulló, M
   Fitó, M
   Tormos, C
   Cerdá, C
   Casillas, R
   Moreno, JJ
   Iradi, A
   Zaragoza, C
   Chaves, J
   Sáez, GT
AF Teresa Mitjavila, Maria
   Fandos, Marta
   Salas-Salvado, Jordi
   Covas, Maria-Isabel
   Borrego, Silvia
   Estruch, Ramon
   Lamuela-Raventos, Rosa
   Corella, Dolores
   Angel Martinez-Gonzalez, Miguel
   Sanchez, Julia M.
   Bullo, Monica
   Fito, Montserrat
   Tormos, Carmen
   Cerda, Concha
   Casillas, Rosario
   Jose Moreno, Juan
   Iradi, Antonio
   Zaragoza, Cristobal
   Chaves, Javier
   Saez, Guillermo T.
CA PREDIMED Study Investigators
TI The Mediterranean diet improves the systemic lipid and DNA oxidative
   damage in metabolic syndrome individuals. A randomized, controlled,
   trial
SO CLINICAL NUTRITION
LA English
DT Article
DE Mediterranean diet; Oxidative stress; Metabolic syndrome; DNA damage;
   F2-isoprostanes; PREDIMED
ID OLIVE OILS; PHENOLIC-COMPOUNDS; OXIDIZED LDL; STRESS; METAANALYSIS;
   PREVALENCE; NUTRITION; ADHERENCE; HUMANS; PLASMA
AB Background Ea aims: Metabolic syndrome (MetS), in which a non-classic feature is an increase in systemic oxidative biomarkers, presents a high risk of diabetes and cardiovascular disease (CVD). Adherence to the Mediterranean Diet (MedDiet) is associated with a reduced risk of MetS. However, the effect of the MedDiet on biomarkers for oxidative damage has not been assessed in MetS individuals. We have investigated the effect of the MedDiet on systemic oxidative biomarkers in MetS individuals.
   Methods: Randomized, controlled, parallel clinical trial in which 110 female With MetS, aged 55-80, were recruited into a large trial (PREDIMED Study) to test the efficacy of the traditional MedDiet on the primary prevention of CVD. Participants were assigned to a low-fat diet or two traditional MedDiets (MedDiet + virgin olive oil or MedDiet + nuts). Both MedDiet group participants received nutritional education and either free extra virgin olive oil for all the family (1 L/week), or free nuts (30 g/day). Diets were ad libitum. Changes in urine levels of F2-lsoprostane (F2-IP) and the DNA damage base 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) were evaluated at 1-year trial.
   Results: After 1-year urinary F2-IP decreased in all groups, the decrease in MedDiet groups reaching a borderline significance versus that of the Control group. Urinary 8-oxo-dG was also reduced in all groups, with a higher decrease in both MedDiet groups versus the Control one (P < 0.001).
   Conclusions: MedDiet reduces oxidative damage to lipids and DNA in MetS individuals. Data from this study provide evidence to recommend the traditional MedDiet as a useful tool in the MetS management. Registered under Clinical Trials.gov Identifier no. NCT00123456. (C) 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Teresa Mitjavila, Maria; Casillas, Rosario; Jose Moreno, Juan] Univ Barcelona, Dept Physiol, INSA, E-08007 Barcelona, Spain.
   [Fandos, Marta; Borrego, Silvia; Sanchez, Julia M.; Tormos, Carmen; Zaragoza, Cristobal; Saez, Guillermo T.] Univ Valencia, Dept Biochem & Mol Biol, Fac Med, INCLIVA, Valencia 46010, Spain.
   [Salas-Salvado, Jordi; Bullo, Monica] Univ Rovira & Virgili, Human Nutr Unit, IISPV, E-43201 Reus, Spain.
   [Salas-Salvado, Jordi; Bullo, Monica] Univ Rovira & Virgili, CIBER Physiopathol Obes & Nutr CIBEROBN, E-43201 Reus, Spain.
   [Covas, Maria-Isabel] IMIM Inst Recerca Hosp del Mar, Cardiovasc Risk & Nutr Res Grp, CIBER Physiopathol Obes & Nutr CIBEROBN, Barcelona, Spain.
   [Estruch, Ramon] Univ Barcelona, Dept Internal Med, IDIBABS, Hosp Clin, E-08007 Barcelona, Spain.
   [Lamuela-Raventos, Rosa] Univ Barcelona, Nutr & Food Sci Dept XaRTA, INSA, E-08007 Barcelona, Spain.
   [Corella, Dolores; Fito, Montserrat] Univ Valencia, Dept Prevent Med, Valencia 46010, Spain.
   [Angel Martinez-Gonzalez, Miguel] Univ Navarra, Dept Prevent Med & Publ Hlth, E-31080 Pamplona, Spain.
   [Cerda, Concha; Saez, Guillermo T.] CDB Gen Univ Hosp, Serv Clin Anal, Valencia, Spain.
   [Iradi, Antonio] Univ Valencia, Dept Physiol, Fac Med, Valencia 46010, Spain.
   [Chaves, Javier] Valencia Clin Hosp Res Fdn INCLIVA, Lab Genet Studies, Valencia, Spain.
C3 University of Barcelona; University of Valencia; Universitat Rovira i
   Virgili; Institut d'Investigacio Sanitaria Pere Virgili (IISPV); CIBER -
   Centro de Investigacion Biomedica en Red; CIBEROBN; Universitat Rovira i
   Virgili; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN;
   Hospital del Mar Research Institute; University of Barcelona; Hospital
   Clinic de Barcelona; University of Barcelona; University of Valencia;
   University of Navarra; University of Valencia
RP Sáez, GT (corresponding author), Univ Valencia, Dept Biochem & Mol Biol, Fac Med, Avda Blasco lbanez 15, Valencia 46010, Spain.
EM guillermo.saez@uv.es
RI Martinez-Gonzalez, Miguel/AAE-7669-2019; Tormo, Julia/JCD-8161-2023;
   Moreno, Juan/AAA-1312-2019; CHAVES, FELIPE/ABC-3294-2021; Corella,
   Dolores/L-9888-2014; Estruch, Ramon/AAZ-3723-2020; Salas-Salvado,
   Jordi/C-7229-2017; Mitjavila, Maria Teresa/D-7474-2014; Fito Colomer,
   Montse/C-1822-2012; Lamuela-Raventos, Rosa M/F-3986-2016; Bullo,
   Monica/F-2925-2016
OI Martinez-Gonzalez, Miguel A./0000-0002-3917-9808; Sanchez Tormo, Julia
   Maria/0000-0001-9341-8737; Salas-Salvado, Jordi/0000-0003-2700-7459;
   Mitjavila, Maria Teresa/0000-0002-1550-6253; Casillas,
   Rosario/0000-0002-6758-6734; Fito Colomer, Montse/0000-0002-1817-483X;
   Lamuela-Raventos, Rosa M/0000-0002-1287-4560; Bullo,
   Monica/0000-0002-0218-7046; Saez, Guillermo/0000-0002-8164-4048; CHAVES,
   FELIPE J/0000-0001-8009-3689
FU Spanish Ministry of Health Instituto de Salud Carlos III [PI1001407, FIS
   PI10/0082, G03/140, RD06/0045]; FEDER (Fondo Europeo de Desarrollo
   Regional); Public Health Division of the Department of Health of the
   Autonomous Government of Catalonia and Caixa Tarragona [10-1343]
FX This study was funded by the Spanish Ministry of Health Instituto de
   Salud Carlos III (PI1001407, FIS PI10/0082, G03/140, RD06/0045), FEDER
   (Fondo Europeo de Desarrollo Regional), the Public Health Division of
   the Department of Health of the Autonomous Government of Catalonia and
   Caixa Tarragona (10-1343). The Fundacion Patrimonio Comunal Olivarero
   and Hojiblanca SA (Malaga, Spain), California Walnut Commission
   (Sacramento, CA), Borges SA (Reus, Spain) and Morella Nuts SA (Reus,
   Spain) donated the olive oil, walnuts, almonds and hazelnuts,
   respectively, used in the PREDIMED study. None of the funding sources
   played a role in the design, collection, analysis or interpretation of
   the data or in the decision to submit the manuscript for publication.
   CIBER de Obesidad y Nutricion is an initiative of the Instituto de Salud
   Carlos III. The authors thank the participants for their enthusiastic
   collaboration, the PREDIMED personnel for excellent assistance and the
   personnel of all affiliated primary care centers.
CR Andreassi MG, 2003, MUTAT RES-REV MUTAT, V543, P67, DOI 10.1016/S1383-5742(02)00089-3
   [Anonymous], INT J EPIDEMIOL
   [Anonymous], ANN ONCOL
   Bedard A, 2012, BR J NUTR, V6, P1
   Bloomer RJ, 2010, GENDER MED, V7, P340, DOI 10.1016/j.genm.2010.07.001
   BROWN RK, 1995, FREE RADICAL BIO MED, V18, P801, DOI 10.1016/0891-5849(94)00172-G
   Cameron AJ, 2004, ENDOCRIN METAB CLIN, V33, P351, DOI 10.1016/j.ecl.2004.03.005
   Chen G, 2004, NUTR CANCER, V50, P155, DOI 10.1207/s15327914nc5002_4
   Davies SS, 2011, FREE RADICAL BIO MED, V50, P559, DOI 10.1016/j.freeradbiomed.2010.11.023
   De Nunzio C, 2011, PROSTATE, V25
   Demirbag R, 2006, INT J CLIN PRACT, V60, P1187, DOI 10.1111/j.1742-1241.2006.01042.x
   Espinosa O, 2007, FREE RADICAL RES, V41, P546, DOI 10.1080/10715760601164050
   Estruch R, 2006, ANN INTERN MED, V145, P1, DOI 10.7326/0003-4819-145-1-200607040-00004
   Fernández-Ballarth JD, 2010, BRIT J NUTR, V103, P1808, DOI 10.1017/S0007114509993837
   Fitó M, 2007, ARCH INTERN MED, V167, P1195, DOI 10.1001/archinte.167.11.1195
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Guevara R, 2009, FREE RADICAL BIO MED, V46, P169, DOI 10.1016/j.freeradbiomed.2008.09.035
   Hansen BC, 1999, ANN NY ACAD SCI, V18, P8921
   Hollman PCH, 2011, J NUTR, V141, p989S, DOI 10.3945/jn.110.131490
   Holvoet P, 2008, FUTURE LIPIDOL, V3, P637, DOI 10.2217/17460875.3.6.637
   Kastorini CM, 2011, J AM COLL CARDIOL, V57, P1299, DOI 10.1016/j.jacc.2010.09.073
   Krauss RM, 2000, CIRCULATION, V102, P2284
   Kris-Etherton PM, 2001, NUTR REV, V59, P103, DOI 10.1111/j.1753-4887.2001.tb06996.x
   Lapointe A, 2006, NUTR REV, V64, P234, DOI 10.1301/nr.2006.may.234-249
   López-Uriarte P, 2010, CLIN NUTR, V29, P373, DOI 10.1016/j.clnu.2009.12.008
   Machowetz A, 2007, FASEB J, V21, P45, DOI 10.1096/fj.06-6328com
   Martinez-Hervas S, 2008, ATHEROSCLEROSIS, V199, P384, DOI 10.1016/j.atherosclerosis.2007.11.023
   Maynard S, 2009, CARCINOGENESIS, V30, P2, DOI 10.1093/carcin/bgn250
   Miller ER, 2005, ATHEROSCLEROSIS, V183, P175, DOI 10.1016/j.atherosclerosis.2005.04.001
   MORROW JD, 1990, P NATL ACAD SCI USA, V87, P9383, DOI 10.1073/pnas.87.23.9383
   Owen RW, 2000, FOOD CHEM TOXICOL, V38, P647, DOI 10.1016/S0278-6915(00)00061-2
   Panagiotakos DB, 2004, AM HEART J, V147, P106, DOI 10.1016/S0002-8703(03)00442-3
   Pelucchi C, 2010, EUR J CANCER, V46, P1866, DOI 10.1016/j.ejca.2010.03.010
   Sáez GT, 2004, AM J HYPERTENS, V17, P809, DOI 10.1016/j.amjhyper.2004.05.022
   Salas-Salvadó J, 2008, ARCH INTERN MED, V168, P2449, DOI 10.1001/archinte.168.22.2449
   Salvini S, 2006, BRIT J NUTR, V95, P742, DOI 10.1079/BJN20051674
   Schröder H, 2011, J NUTR, V141, P1140, DOI 10.3945/jn.110.135566
   Shishehbor MH, 2006, FREE RADICAL BIO MED, V41, P1678, DOI 10.1016/j.freeradbiomed.2006.09.001
   Siegel AB, 2009, CANCER-AM CANCER SOC, V115, P5651, DOI 10.1002/cncr.24687
   Tortosa A, 2007, DIABETES CARE, V30, P2957, DOI 10.2337/dc07-1231
   Trichopoulou A, 2003, NEW ENGL J MED, V348, P2599, DOI 10.1056/NEJMoa025039
   Tsai IJ, 2009, FREE RADICAL BIO MED, V46, P263, DOI 10.1016/j.freeradbiomed.2008.10.028
   Weinbrenner T, 2004, J NUTR, V134, P2314, DOI 10.1093/jn/134.9.2314
NR 44
TC 154
Z9 159
U1 0
U2 58
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD APR
PY 2013
VL 32
IS 2
BP 172
EP 178
DI 10.1016/j.clnu.2012.08.002
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 115UV
UT WOS:000316838300003
PM 22999065
DA 2025-06-11
ER

PT J
AU Bo, S
   Gambino, R
   Durazzo, M
   Ghione, F
   Musso, G
   Gentile, L
   Cassader, M
   Cavallo-Perin, P
   Pagano, G
AF Bo, S.
   Gambino, R.
   Durazzo, M.
   Ghione, F.
   Musso, G.
   Gentile, L.
   Cassader, M.
   Cavallo-Perin, P.
   Pagano, G.
TI Associations between serum uric acid and adipokines, markers of
   inflammation, and endothelial dysfunction
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE uric acid; adipokines; inflammation; oxidative stress; endothelial
   dysfunction
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; ADHESION MOLECULES; CAROTID ATHEROSCLEROSIS;
   CELL-PROLIFERATION; INSULIN-RESISTANCE; LEPTIN; RISK
AB Aim: Serum uric acid is associated with the metabolic syndrome and its components, while its relationship with cardiovascular disease is controversial. The aim of the study was to evaluate the association between uric acid and adipokines, markers of inflammation, oxidative stress, and endothelial dysfunction, which are all linked to cardiovascular disease. Methods: The associations between uric acid and adiponectin, resistin, leptin, high-sensitivity-C-reactive protein (hs-CRP), interleukin-6, tumor necrosis factor-alpha, nitrotyrosine, Total Antioxidant Status (TAS), E-selectin, vascular adhesion molecule-1 (VCAM-1), and intercellular adhesion molecule-1 (ICAM-1) were cross-sectionally evaluated in a randomly collected sample of 100 men from a population-based cohort. Results: Subjects within the highest uric acid quartile showed a worse metabolic pattern and a higher prevalence of the metabolic syndrome [odds ratio (OR)=3.6; 95% confidence interval (CI) 1.6-8.2; p < 0.001 for each 50 mu mol/l uric acid increment in a logistic regression model after multiple adjustments]. Nitrotyrosine and adiponectin were significantly lower, while TAS, hs-CRP, E-selectin, ICAM-1, and VCAM-1 were higher in the groups with increased uric acid levels. In a multiple regression model, after adjustments for multiple con-founders, uric acid levels were inversely associated with nitrotyrosine (p < 0.001) and adiponectin (p=0.02), and directly with TAS (p < 0.001), and E-selectin (p=0.006). Conclusion: Serum uric acid showed opposite relationships, being associated with both beneficial (inverse association with nitrotyrosine, direct association with TAS) and detrimental (inverse association with adiponectin, direct association with E-selectin) markers, thus providing a possible explanation for the previously reported controversial and not linear association between uric acid and cardiovascular disease.
C1 [Bo, S.; Gambino, R.; Durazzo, M.; Ghione, F.; Musso, G.; Cassader, M.; Cavallo-Perin, P.; Pagano, G.] Univ Turin, Dept Internal Med, I-10126 Turin, Italy.
   [Gentile, L.] Hosp Asti, Diabet Clin, Asti, Italy.
C3 University of Turin
RP Bo, S (corresponding author), Univ Turin, Dept Internal Med, Corso Dogliotti 14, I-10126 Turin, Italy.
EM sbo@molinette.piemonte.it
RI GAMBINO, Roberto/AAC-7517-2022; Bo, Simona/AAC-1110-2019
OI Bo, Simona/0000-0001-6862-8628; DURAZZO, Marilena/0000-0003-2450-5911
CR Baker JF, 2005, AM J MED, V118, P816, DOI 10.1016/j.amjmed.2005.03.043
   Bedir A, 2003, JPN HEART J, V44, P527, DOI 10.1536/jhj.44.527
   Bo S, 2005, DIABETES-METAB RES, V21, P515, DOI 10.1002/dmrr.561
   Bo S, 2005, EUR J CLIN INVEST, V35, P265, DOI 10.1111/j.1365-2362.2005.01490.x
   Bo S, 2006, AM J CLIN NUTR, V84, P1062, DOI 10.1093/ajcn/84.5.1062
   Cesari M, 2003, CIRCULATION, V108, P2317, DOI 10.1161/01.CIR.0000097109.90783.FC
   Chandran M, 2003, DIABETES CARE, V26, P2442, DOI 10.2337/diacare.26.8.2442
   Chen NG, 1999, J CLIN ENDOCR METAB, V84, P3485, DOI 10.1210/jc.84.10.3485
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   COCKCROFT DW, 1976, NEPHRON, V16, P31, DOI 10.1159/000180580
   Dawson J, 2006, BRIT J CLIN PHARMACO, V62, P633, DOI 10.1111/j.1365-2125.2006.02785.x
   Fruehwald-Schultes B, 1999, METABOLISM, V48, P677, DOI 10.1016/S0026-0495(99)90163-4
   GALVAN AQ, 1995, AM J PHYSIOL-ENDOC M, V268, pE1, DOI 10.1152/ajpendo.1995.268.1.E1
   Hayden Melvin R, 2004, Nutr Metab (Lond), V1, P10, DOI 10.1186/1743-7075-1-10
   Hwang SJ, 1997, CIRCULATION, V96, P4219
   Ishizaka N, 2005, ARTERIOSCL THROM VAS, V25, P1038, DOI 10.1161/01.ATV.0000161274.87407.26
   Johnson RJ, 2005, AM J HYPERTENS, V18, P431, DOI 10.1016/j.amjhyper.2004.08.035
   Kanellis J, 2005, SEMIN NEPHROL, V25, P39, DOI 10.1016/j.semnephrol.2004.09.007
   Kang DH, 2005, J AM SOC NEPHROL, V16, P3553, DOI 10.1681/ASN.2005050572
   Kroke A, 1999, AM J CLIN NUTR, V70, P439
   Leyva F, 1998, EUR HEART J, V19, P1814, DOI 10.1053/euhj.1998.1188
   Matsubara Miyao, 2002, J Atheroscler Thromb, V9, P28
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mercuro G, 2004, AM J CARDIOL, V94, P932, DOI 10.1016/j.amjcard.2004.06.032
   Onat A, 2006, AM J HYPERTENS, V19, P1055, DOI 10.1016/j.amjhyper.2006.02.014
   Ouchi N, 1999, CIRCULATION, V100, P2473, DOI 10.1161/01.CIR.100.25.2473
   Patterson RA, 2003, J LIPID RES, V44, P512, DOI 10.1194/jlr.M200407-JLR200
   Pischon T, 2004, JAMA-J AM MED ASSOC, V291, P1730, DOI 10.1001/jama.291.14.1730
   RAO GN, 1991, J BIOL CHEM, V266, P8604
   Reilly MP, 2005, CIRCULATION, V111, P932, DOI 10.1161/01.CIR.0000155620.10387.43
   Ridker PM, 2000, NEW ENGL J MED, V342, P836, DOI 10.1056/NEJM200003233421202
   Ruggiero C, 2006, EUR HEART J, V27, P1174, DOI 10.1093/eurheatj/ehi879
   SALTIN B, 1968, CIRCULATION, V38, P1104, DOI 10.1161/01.CIR.38.6.1104
   Santos CXC, 1999, ARCH BIOCHEM BIOPHYS, V372, P285, DOI 10.1006/abbi.1999.1491
   Shishehbor MH, 2003, JAMA-J AM MED ASSOC, V289, P1675, DOI 10.1001/jama.289.13.1675
   Short RA, 2006, AM J HYPERTENS, V19, P1063, DOI 10.1016/j.amjhyper.2006.03.011
   Suliman ME, 2006, AM J KIDNEY DIS, V48, P761, DOI 10.1053/j.ajkd.2006.08.019
   terMaaten JC, 1997, CLIN SCI, V92, P51
   Tsouli SG, 2006, METABOLISM, V55, P1293, DOI 10.1016/j.metabol.2006.05.013
   Wallace AM, 2001, CIRCULATION, V104, P3052, DOI 10.1161/hc5001.101061
   Waring WS, 2004, HEART, V90, P155, DOI 10.1136/hrt.2003.016121
   Waring WS, 2003, CLIN SCI, V105, P425, DOI 10.1042/CS20030149
   Wheeler JG, 2005, PLOS MED, V2, P236, DOI 10.1371/journal.pmed.0020076
NR 43
TC 35
Z9 43
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0391-4097
EI 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD JUN
PY 2008
VL 31
IS 6
BP 499
EP 504
DI 10.1007/BF03346397
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 327HP
UT WOS:000257720500003
PM 18591880
DA 2025-06-11
ER

PT J
AU Hemingway, H
   Shipley, M
   Brunner, E
   Britton, A
   Malik, M
   Marmot, M
AF Hemingway, H
   Shipley, M
   Brunner, E
   Britton, A
   Malik, M
   Marmot, M
TI Does autonomic function link social position to coronary risk? The
   Whitehall II study
SO CIRCULATION
LA English
DT Article
DE disparities; metabolism; psychosocial factors; social factors; stress
ID HEART-RATE-VARIABILITY; SUDDEN CARDIAC DEATH; ALL-CAUSE MORTALITY;
   ATHEROSCLEROSIS RISK; METABOLIC SYNDROME; CARDIOVASCULAR MORTALITY;
   PSYCHOSOCIAL FACTORS; JOB CONTROL; DISEASE; STRESS
AB Background - Laboratory and clinical studies suggest that the autonomic nervous system responds to chronic behavioral and psychosocial stressors with adverse metabolic consequences and that this may explain the relation between low social position and high coronary risk. We sought to test this hypothesis in a healthy occupational cohort.
   Methods and Results - This study comprised 2197 male civil servants 45 to 68 years of age in the Whitehall II study who were undergoing standardized assessments of social position ( employment grade) and the psychosocial, behavioral, and metabolic risk factors for coronary disease previously found to be associated with low social position. Five-minute recordings of heart rate variability (HRV) were used to assess cardiac parasympathetic function (SD of N-N intervals and high-frequency power [0.15 to 0.40 Hz]) and the influence of sympathetic and parasympathetic function (low-frequency power [0.04 to 0.15 Hz]). Low employment grade was associated with low HRV (age-adjusted trend for each modality, P <= 0.02). Adverse behavioral factors ( smoking, exercise, alcohol, and diet) and psychosocial factors ( job control) showed age-adjusted associations with low HRV (P < 0.03). The age-adjusted mean low-frequency power was 319 ms(2) among those participants in the bottom tertile of job control compared with 379 ms2 in the other participants (P = 0.004). HRV showed strong (P < 0.001) linear associations with components of the metabolic syndrome ( waist circumference, systolic blood pressure, HDL cholesterol, triglycerides, and fasting and 2-hour postload glucose). The social gradient in prevalence of metabolic syndrome was explained statistically by adjustment for low-frequency power, behavioral factors, and job control.
   Conclusions - Chronically impaired autonomic function may link social position to different components of coronary risk in the general population.
C1 UCL, Dept Epidemiol & Publ Hlth, Int Ctr Hlth & Soc, Sch Med, London WC1E 6BT, England.
   St George Hosp, Sch Med, London, England.
C3 University of London; University College London; UCL Medical School;
   City St Georges, University of London
RP UCL, Dept Epidemiol & Publ Hlth, Int Ctr Hlth & Soc, Sch Med, 1-19 Torrington Pl, London WC1E 6BT, England.
EM h.hemingway@ucl.ac.uk
RI Malik, Marek/KCY-3775-2024; Brunner, Eric/H-2114-2011; Marmot,
   Michael/Y-3920-2019; Hemingway, Harry/C-1219-2009
OI Marmot, Michael/0000-0002-2431-6419; Malik, Marek/0000-0002-3792-1407;
   Hemingway, Harry/0000-0003-2279-0624; Brunner, Eric/0000-0002-0595-4474
FU AHRQ HHS [5 R01 HS06516] Funding Source: Medline; Medical Research
   Council [G0100222, G19/35, G8802774] Funding Source: Medline; NHLBI NIH
   HHS [2R01 HL-36310] Funding Source: Medline; NIA NIH HHS [R01
   AG13196-02] Funding Source: Medline
CR Acar B, 2000, COMPUT METH PROG BIO, V63, P123, DOI 10.1016/S0169-2607(00)00081-X
   Benetos A, 1999, HYPERTENSION, V33, P44, DOI 10.1161/01.HYP.33.1.44
   BIGGER JT, 1993, CIRCULATION, V88, P927, DOI 10.1161/01.CIR.88.3.927
   Bosma H, 1997, BMJ-BRIT MED J, V314, P558, DOI 10.1136/bmj.314.7080.558
   Britton A, 2004, DYNAMIC ELECTROCARDIOGRAPHY, P90, DOI 10.1002/9780470987483.ch11
   Brook RD, 2000, AM J HYPERTENS, V13, p112S, DOI 10.1016/S0895-7061(00)00228-4
   Brunner E, 2001, BRIT J NUTR, V86, P405, DOI 10.1079/BJN2001414
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   Brunner EJ, 1997, DIABETOLOGIA, V40, P1341, DOI 10.1007/s001250050830
   Camm AJ, 1996, CIRCULATION, V93, P1043
   Carnethon MR, 2003, CIRCULATION, V107, P2190, DOI 10.1161/01.CIR.0000066324.74807.95
   Carnethon MR, 2002, AM J EPIDEMIOL, V155, P48, DOI 10.1093/aje/155.1.48
   Carney RM, 2001, CIRCULATION, V104, P2024, DOI 10.1161/hc4201.097834
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   de Bruyne MC, 1999, EUR HEART J, V20, P278, DOI 10.1053/euhj.1998.1276
   Dekker JM, 2000, CIRCULATION, V102, P1239, DOI 10.1161/01.CIR.102.11.1239
   Dekker JM, 1997, AM J EPIDEMIOL, V145, P899, DOI 10.1093/oxfordjournals.aje.a009049
   Epel E, 2004, ANN NY ACAD SCI, V1032, P208, DOI 10.1196/annals.1314.022
   GILLUM RF, 1992, PUBLIC HEALTH REP, V107, P193
   Greenland P, 1999, AM J EPIDEMIOL, V149, P853
   Hemingway H, 1999, BMJ-BRIT MED J, V318, P1460, DOI 10.1136/bmj.318.7196.1460
   Hemingway H, 2001, EUR HEART J, V22, P1082, DOI 10.1053/euhj.2000.2534
   Horsten M, 1999, PSYCHOSOM MED, V61, P49, DOI 10.1097/00006842-199901000-00009
   Huikuri HV, 1998, CIRCULATION, V97, P2031, DOI 10.1161/01.CIR.97.20.2031
   Kageyama T, 1998, IND HEALTH, V36, P263, DOI 10.2486/indhealth.36.263
   KAPLAN JR, 1991, CIRCULATION, V84, P23
   KAWACHI I, 1995, AM J CARDIOL, V75, P882, DOI 10.1016/S0002-9149(99)80680-8
   Kivimäki M, 2002, BRIT MED J, V325, P857, DOI 10.1136/bmj.325.7369.857
   Liao DP, 1998, DIABETES CARE, V21, P2116, DOI 10.2337/diacare.21.12.2116
   Liao DP, 1997, AM J EPIDEMIOL, V145, P696, DOI 10.1093/aje/145.8.696
   Lucki I, 1998, BIOL PSYCHIAT, V44, P151, DOI 10.1016/S0006-3223(98)00139-5
   Lynch JW, 1996, AM J EPIDEMIOL, V144, P934, DOI 10.1093/oxfordjournals.aje.a008863
   Marmot M, 2001, NEW ENGL J MED, V345, P134, DOI 10.1056/NEJM200107123450210
   MARMOT MG, 1991, LANCET, V337, P1387, DOI 10.1016/0140-6736(91)93068-K
   Marmot MG, 1997, LANCET, V350, P235, DOI 10.1016/S0140-6736(97)04244-X
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   Muldoon MF, 2004, J CLIN ENDOCR METAB, V89, P266, DOI 10.1210/jc.2003-031295
   Nonogaki K, 2000, DIABETOLOGIA, V43, P533, DOI 10.1007/s001250051341
   Phillips DIW, 1998, J CLIN ENDOCR METAB, V83, P757, DOI 10.1210/jc.83.3.757
   Pikkujämsä SM, 1998, AM J HYPERTENS, V11, P523, DOI 10.1016/S0895-7061(98)00035-1
   Ramage AG, 2001, BRAIN RES BULL, V56, P425, DOI 10.1016/S0361-9230(01)00612-8
   Reaven GM, 1996, NEW ENGL J MED, V334, P374, DOI 10.1056/NEJM199602083340607
   Rennie KL, 2003, AM J EPIDEMIOL, V158, P135, DOI 10.1093/aje/kwg120
   Rozanski A, 1999, CIRCULATION, V99, P2192, DOI 10.1161/01.CIR.99.16.2192
   Schafer JL, 1997, ANAL INCOMPLETE MULT
   SHAPER AG, 1993, BRIT HEART J, V70, P49
   Singh JP, 1998, HYPERTENSION, V32, P293, DOI 10.1161/01.HYP.32.2.293
   Singh JP, 2000, AM J CARDIOL, V86, P309, DOI 10.1016/S0002-9149(00)00920-6
   Sinnreich R, 1998, HEART, V80, P156, DOI 10.1136/hrt.80.2.156
   Steptoe A, 2002, EUR HEART J, V23, P13, DOI 10.1053/euhj.2001.2611
   Tsuji H, 1996, CIRCULATION, V94, P2850, DOI 10.1161/01.CIR.94.11.2850
NR 51
TC 166
Z9 182
U1 0
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD JUN 14
PY 2005
VL 111
IS 23
BP 3071
EP 3077
DI 10.1161/CIRCULATIONAHA.104.497347
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 935IF
UT WOS:000229773500010
PM 15939818
OA Bronze
DA 2025-06-11
ER

PT J
AU Aladdin, N
   Ghareib, SA
AF Aladdin, Noha
   Ghareib, Salah A.
TI Vitamin D3 Exerts a Neuroprotective Effect in Metabolic Syndrome Rats:
   Role of BDNF/TRKB/Akt/GS3Kβ Pathway
SO JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
LA English
DT Article
DE brain-derived neurotrophic factor (BDNF); cognitive dysfunction;
   metabolic syndrome; neuropathic pain; VitD3
ID CENTRAL-NERVOUS-SYSTEM; INSULIN-RESISTANCE; NEUROTROPHIC FACTOR;
   ALZHEIMERS-DISEASE; AMYLOID-BETA; D DEFICIENCY; HIGH-FAT; RECEPTOR;
   TRKB; BDNF
AB Metabolic syndrome (MetS) is usually associated with cognitive impairment, neuropathic pain, and reduced brain-derived neurotrophic factor (BDNF) levels. BDNF via tropomyosin receptor kinase B (TrkB) exerts neuroprotection by activating protein kinase B (Akt) to inhibit glycogen synthase kinase-3 beta (GSK3 beta). Although Vitamin D3 (VitD3) has demonstrated favorable metabolic and neuronal outcomes in MetS, the precise molecular mechanisms underlying its neuroprotective effects remain poorly elucidated. We aimed to test the hypothesis that VitD3 mitigates MetS-induced cognition deficits and neuropathic pain via modulating the BDNF/TRKB/Akt/GS3K beta signaling pathway. MetS was induced in male rats by 10% fructose-supplemented water and 3% salt-enriched diet. After 6 weeks, normal and MetS rats received either vehicle or VitD3 (10 mu g/kg/day) for an additional 6 weeks. Glycemic status, lipid profile, and behavioral changes were assessed. The advanced glycation end products (AGEs), and markers of inflammation (TNF-alpha and NF-kappa B), oxidative stress (malondialdehyde), and apoptosis (caspase3), as well as BDNF, TrkB, PI3K, Akt, GSK3 beta, phosphorylated tau, and amyloid beta (A beta) were assessed in the cerebral cortex. MetS rats had deteriorated glycemic and lipid profiles, higher AGEs, reduced levels of BDNF, TrkB, PI3K, and active Akt, along with increased GSK3 beta levels, inflammation, oxidative stress, and apoptosis. These changes were associated with higher levels of cognitive impairment markers phosphorylated tau and A beta, as well as behavioral changes indicative of cognitive impairment and neuropathic pain. VitD3 improved the cognitive and behavioral alterations, while mitigating the associated molecular derangements. Our results indicate that VitD3 may exert neuroprotective effects by modulating the BDNF/TrkB/PI3K/Akt/GSK3 beta signaling pathway.
C1 [Aladdin, Noha; Ghareib, Salah A.] Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University
RP Aladdin, N (corresponding author), Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig, Egypt.
EM rme2991@yahoo.com
RI Atteiah, salah/I-1537-2012
CR Abdallah HM, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1340-5
   AlJohri Reham, 2019, eNeurologicalSci, V14, P43, DOI 10.1016/j.ensci.2018.12.004
   Alshahrani S, 2012, JOVE-J VIS EXP, DOI 10.3791/3785
   Anandabaskar Nishanthi, 2017, Indian J Endocrinol Metab, V21, P555, DOI 10.4103/ijem.IJEM_140_17
   Anjum I, 2018, CUREUS J MED SCIENCE, V10, DOI 10.7759/cureus.2960
   Antonijevic M, 2023, EUR J MED CHEM, V248, DOI 10.1016/j.ejmech.2023.115111
   Baas D, 2000, GLIA, V31, P59, DOI 10.1002/(SICI)1098-1136(200007)31:1<59::AID-GLIA60>3.0.CO;2-Y
   Balaraman Y, 2006, CELL MOL LIFE SCI, V63, P1226, DOI 10.1007/s00018-005-5597-y
   Banerjee A., 2015, Int. J. Alzheimers Dis, V2015, P1, DOI DOI 10.1155/2015/192747
   Banfield MJ, 2001, STRUCTURE, V9, P1191, DOI 10.1016/S0969-2126(01)00681-5
   Barakat W., 2014, Zagazig University Medical Journal, V23, P58
   Barzilay JI, 2021, J DIABETES COMPLICAT, V35, DOI 10.1016/j.jdiacomp.2021.108047
   Benetti E, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0189707
   Bortolotto VC, 2021, J PSYCHIATR RES, V144, P225, DOI 10.1016/j.jpsychires.2021.10.018
   Bouillon R, 2008, ENDOCR REV, V29, P726, DOI 10.1210/er.2008-0004
   Briones TL, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-244
   Broom L, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-03336-1
   Carter R J, 2001, Curr Protoc Neurosci, VChapter 8, DOI 10.1002/0471142301.ns0812s15
   Chemical Computing Group, Molecular operating environment (moe 2019.0102) chemical computing group inc. montreal quebec Canada
   Chen Y, 2013, J BIOL CHEM, V288, P19450, DOI 10.1074/jbc.M113.467670
   Chiang NN, 2021, FRONT AGING NEUROSCI, V13, DOI 10.3389/fnagi.2021.758895
   Chitranshi N, 2016, DATA BRIEF, V6, P776, DOI 10.1016/j.dib.2016.01.016
   Chitranshi N, 2015, INT J MOL SCI, V16, P21087, DOI 10.3390/ijms160921087
   Chiu YJ, 2022, AGING-US, V14, P7568, DOI 10.18632/aging.204306
   Cui CM, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/9245702
   Cui XY, 2022, NUTRIENTS, V14, DOI 10.3390/nu14204353
   DaRocha-Souto B, 2012, NEUROBIOL DIS, V45, P425, DOI 10.1016/j.nbd.2011.09.002
   de la Monte SM, 2017, DRUGS, V77, P47, DOI 10.1007/s40265-016-0674-0
   Duan WZ, 2003, P NATL ACAD SCI USA, V100, P2911, DOI 10.1073/pnas.0536856100
   Elston GN, 2003, CEREB CORTEX, V13, P1124, DOI 10.1093/cercor/bhg093
   Exalto LG, 2012, EXP GERONTOL, V47, P858, DOI 10.1016/j.exger.2012.07.014
   Fan YG, 2020, FREE RADICAL BIO MED, V161, P139, DOI 10.1016/j.freeradbiomed.2020.10.007
   Fedotova JO, 2019, BMC MED GENET, V20, DOI 10.1186/s12881-019-0774-2
   Frisardi V, 2010, J ALZHEIMERS DIS, V22, P715, DOI 10.3233/JAD-2010-100942
   Garcion E, 1997, MOL BRAIN RES, V45, P255, DOI 10.1016/S0169-328X(96)00260-4
   Gezen-Ak D, 2017, ACS CHEM NEUROSCI, V8, P2335, DOI 10.1021/acschemneuro.7b00245
   Greenwood CE, 2005, NEUROBIOL AGING, V26, pS42, DOI 10.1016/j.neurobiolaging.2005.08.017
   Guo T, 2017, ACTA NEUROPATHOL, V133, P665, DOI 10.1007/s00401-017-1707-9
   Han C, 2016, AM J PHYSIOL-ENDOC M, V311, pE32, DOI 10.1152/ajpendo.00012.2016
   Han L, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/s13098-015-0010-y
   Helde-Frankling M, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18102170
   Hempstead Barbara L., 2006, Current Alzheimer Research, V3, P19, DOI 10.2174/156720506775697061
   Hewison M, 2010, ENDOCRIN METAB CLIN, V39, P365, DOI [10.1016/j.ecl.2010.02.010, 10.1016/j.rdc.2012.03.012]
   Hii CS, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030135
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Hu ZX, 2020, CELL DEATH DIS, V11, DOI 10.1038/s41419-020-2256-z
   Irwin David J, 2018, J Alzheimers Dis Parkinsonism, V8, DOI 10.4172/2161-0460.1000444
   Jacobs K. M., 2012, International Journal of Cell Biology, V930710, P21
   Janardhanan A, 2016, NEUROPSYCHOBIOLOGY, V74, P104, DOI 10.1159/000454985
   Janson J, 2004, DIABETES, V53, P474, DOI 10.2337/diabetes.53.2.474
   Jiang T, 2017, KOREAN J PHYSIOL PHA, V21, P579, DOI 10.4196/kjpp.2017.21.6.579
   Johnson RJ, 2013, DIABETES, V62, P3307, DOI 10.2337/db12-1814
   Tinahones FJ, 2013, DIABETES CARE, V36, P513, DOI 10.2337/dc12-0194
   Kalwat MA, 2018, J GEN PHYSIOL, V150, P1747, DOI 10.1085/jgp.201812177
   Kang JH, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-02485-8
   Kashani HH, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00050
   Kazamel M, 2021, MUSCLE NERVE, V63, P285, DOI 10.1002/mus.27086
   Ke BX, 2019, MED SCI MONITOR, V25, P3336, DOI 10.12659/MSM.914653
   Kim B, 2015, EXP MOL MED, V47, DOI 10.1038/emm.2015.3
   Kim M, 2014, INT NEUROUROL J, V18, P115, DOI 10.5213/inj.2014.18.3.115
   Kothayer H, 2019, DRUG DEVELOP RES, V80, P343, DOI 10.1002/ddr.21506
   Kraeuter A. K., 2019, Methods in Molecular Biology, V1916, P8994
   Lasón W, 2023, CELLS-BASEL, V12, DOI 10.3390/cells12040660
   Lee PCW, 2020, FRONT NEUROL, V11, DOI 10.3389/fneur.2020.00019
   Li HWR, 2011, METABOLISM, V60, P1475, DOI 10.1016/j.metabol.2011.03.002
   Lima LAR, 2018, J NEUROINFLAMM, V15, DOI 10.1186/s12974-018-1266-6
   Lin JS, 2022, NEUROSCI LETT, V783, DOI 10.1016/j.neulet.2022.136725
   Liu CY, 2016, TRANSL NEURODEGENER, V5, DOI 10.1186/s40035-015-0048-7
   Liu HQ, 2012, BRAIN RES BULL, V89, P65, DOI 10.1016/j.brainresbull.2012.06.010
   Maixner D. W., 2013, Journal of Pharmacy and Pharmacology, V1
   Manjari SKV, 2024, MOL NEUROBIOL, V61, P7211, DOI 10.1007/s12035-024-03989-w
   Manjari SKV, 2023, IBRO NEUROSCI REP, V15, P116, DOI 10.1016/j.ibneur.2023.07.001
   Manjari SKV, 2022, NEUROSCIENCE, V492, P67, DOI 10.1016/j.neuroscience.2022.03.039
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Miller WP, 2019, INVEST OPHTH VIS SCI, V60, P2369, DOI 10.1167/iovs.19-26606
   Mines MA., 2011, International Journal of Alzheimer's Disease, V2011, P861072, DOI DOI 10.4061/2011/861072
   Moller DE, 2005, ANNU REV MED, V56, P45, DOI 10.1146/annurev.med.56.082103.104751
   Molteni R, 2002, NEUROSCIENCE, V112, P803, DOI 10.1016/S0306-4522(02)00123-9
   Morello M, 2018, MOL NEUROBIOL, V55, P6463, DOI 10.1007/s12035-017-0839-1
   Mullins RJ, 2017, FRONT AGING NEUROSCI, V9, DOI 10.3389/fnagi.2017.00118
   Nadimi H, 2020, IRAN J BASIC MED SCI, V23, P117, DOI 10.22038/IJBMS.2019.38170.9068
   NYOMBA BL, 1985, ENDOCRINOLOGY, V116, P2483, DOI 10.1210/endo-116-6-2483
   Piquer S., 2010, Hippocampus, V21, P910
   Podyma B, 2021, TRENDS ENDOCRIN MET, V32, P488, DOI 10.1016/j.tem.2021.04.005
   Prieur EAK, 2019, BIO-PROTOCOL, V9, DOI 10.21769/BioProtoc.3162
   Prüfer K, 1999, J CHEM NEUROANAT, V16, P135, DOI 10.1016/S0891-0618(99)00002-2
   Qu GB, 2017, J CLIN TRANSL ENDOCR, V9, P25, DOI 10.1016/j.jcte.2017.04.001
   Rajmohan R, 2017, J ALZHEIMERS DIS, V57, P975, DOI 10.3233/JAD-160612
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Rebolledo-Solleiro D, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0176554
   Rezq S, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-77424-0
   Saeed A, 2017, BIOMED RES THER, V4, P1305, DOI 10.15419/bmrat.v4i05.169
   Sangkaew B, 2018, GENE, V659, P59, DOI 10.1016/j.gene.2018.03.047
   Schuch NJ, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-96
   Scrimgeour AG, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.685220
   Seibenhener ML, 2015, JOVE-J VIS EXP, DOI 10.3791/52434
   Simmons DA, 2011, NEUROBIOL DIS, V41, P436, DOI 10.1016/j.nbd.2010.10.015
   Stino AM, 2017, J DIABETES INVEST, V8, P646, DOI 10.1111/jdi.12650
   Stranahan AM, 2008, HIPPOCAMPUS, V18, P1085, DOI 10.1002/hipo.20470
   Sugimoto H., 2019, Journal of Visualized Experiments: JoVE, V23
   Talaei A, 2013, DIABETOL METAB SYNDR, V5, DOI 10.1186/1758-5996-5-8
   Tanriover G, 2010, FOLIA HISTOCHEM CYTO, V48, P434, DOI 10.2478/v10042-010-0047-6
   Toral-Rios D, 2020, FRONT CELL NEUROSCI, V14, DOI 10.3389/fncel.2020.00019
   Varghese JE, 2020, J KING SAUD UNIV SCI, V32, P2786, DOI 10.1016/j.jksus.2020.06.015
   Veluthakal R, 2016, CELL PHYSIOL BIOCHEM, V39, P2110, DOI 10.1159/000447907
   Virtuoso A, 2023, NEURAL REGEN RES, V18, P1025, DOI 10.4103/1673-5374.355754
   Wahba NS, 2021, EUR J NUTR, V60, P299, DOI 10.1007/s00394-020-02249-6
   Walf AA, 2007, NAT PROTOC, V2, P322, DOI 10.1038/nprot.2007.44
   Wang X, 2016, BIOCHEM BIOPH RES CO, V473, P428, DOI 10.1016/j.bbrc.2016.03.024
   Wu JC, 2018, BIOCHEM BIOPH RES CO, V495, P2462, DOI 10.1016/j.bbrc.2017.12.146
   Wu TY, 2022, NEUROCHEM INT, V153, DOI 10.1016/j.neuint.2021.105260
   Wurzelmann M, 2017, NEURAL REGEN RES, V12, P7, DOI 10.4103/1673-5374.198964
   Yang LY, 2018, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00073
   Yang SJ, 2022, CURR NEUROPHARMACOL, V20, P1479, DOI 10.2174/1570159X19666210915122820
   Yeo GSH, 2004, NAT NEUROSCI, V7, P1187, DOI 10.1038/nn1336
   Yoshizaki K, 2020, NUTRIENTS, V12, DOI 10.3390/nu12072036
   Zaulkffali AS, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102525
   Zhao WQ, 2009, BBA-MOL BASIS DIS, V1792, P482, DOI 10.1016/j.bbadis.2008.10.014
NR 118
TC 0
Z9 0
U1 2
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1095-6670
EI 1099-0461
J9 J BIOCHEM MOL TOXIC
JI J. Biochem. Mol. Toxicol.
PD DEC
PY 2024
VL 38
IS 12
AR e70082
DI 10.1002/jbt.70082
PG 15
WC Biochemistry & Molecular Biology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Toxicology
GA O6T1C
UT WOS:001372415900001
PM 39651608
DA 2025-06-11
ER

PT J
AU di Maio, G
   Monda, V
   Messina, A
   Polito, R
   Monda, M
   Tartaglia, N
   Ambrosio, A
   Pisanelli, D
   Asmundo, A
   di Nunno, N
   Ametta, A
   Villano, I
   Francavilla, VC
AF di Maio, Girolamo
   Monda, Vincenzo
   Messina, Antonietta
   Polito, Rita
   Monda, Marcellino
   Tartaglia, Nicola
   Ambrosio, Antonio
   Pisanelli, Daniela
   Asmundo, Alessio
   di Nunno, Nunzio
   Ametta, Alberto
   Villano, Ines
   Francavilla, Vincenzo Cristian
TI PHYSICAL ACTIVITY AND MODIFICATION OF LIFESTYLE INDUCE BENEFITS ON THE
   HEALTH STATUS
SO ACTA MEDICA MEDITERRANEA
LA English
DT Article
DE Metabolic syndrome (MS); obesity; cardiovascular diseases; diabetes;
   physical exercise; healthy lifestyle
ID METABOLIC SYNDROME; ABDOMINAL OBESITY; SKELETAL-MUSCLE; RISK-FACTORS;
   WEIGHT-LOSS; EXERCISE; INSULIN; MICROPARTICLES; INTERVENTION; POPULATION
AB Introduction: Metabolic syndrome (MS) includes a various factors such as hyperglycemia, high blood pressure and hypercholesterolemia that predispose individuals to the development of cardiovascular disease and diabetes. Furthermore, MS is strongly associated with obesity, indeed, it is well know that abdominal and/or visceral adipose tissue accumulation is a contributory cause of MS development. These diseases are associated with multiple metabolic toxicities resulting from the oxidative stress, which are the product of reactive oxygen species. In this scenario, a corrected nutrition and adequate physical activity are important measures against MS, obesity, aging and prevention of cardiovascular disease and cancer. In this regards, the healthy lifestyle, and in particular correct physical activity, represents one the epigenetic strategies against MS, having beneficial and anti-inflammatory effects, reducing the production of free radicals and the risk to development cardiovascular diseases and diabetes. The aim of this review is to discuss on physical activity and its role in modification of lyfestile inducing beneficial effect on health status.
   Material and method: We performed a data literature analysis from PubMed. We analyze data from multiple studies reporting that physical activity decreases body adiposity and the physical exercise reduces the far mass in a dose dependent. Physical activity decreases abdominal visceral and subcutaneous fat indipendently of changes in dietary energy intake in healthy, overweight and obese man and women, suggesting that training is critical in the treatment, or prevention, of MS. Also, it induces the expression of a many genes involved in the repair of cellular damage and reduces the expression of genes involved in the mechanisms of oxidative stress and inflammation, activating numerous metabolic pathways and down-regulating the production of mediators of inflammation and ROS production.
   Conclusion: the physical activity can be an efficient therapeutic approach in MS, promoting weight loss in obesity and reducing cardiovascular disease and diabetes risks.
C1 [di Maio, Girolamo; Monda, Vincenzo; Messina, Antonietta; Monda, Marcellino; Villano, Ines] Univ Campania Luigi Vanvitelli, Sect Human Physiol, Dept Expt Med, Naples, Italy.
   [di Maio, Girolamo; Monda, Vincenzo; Messina, Antonietta; Monda, Marcellino; Villano, Ines] Univ Campania Luigi Vanvitelli, Unit Dietet & Sport Med, Naples, Italy.
   [Polito, Rita] Univ Foggia, Dept Clin & Expt Med, Foggia, Italy.
   [Tartaglia, Nicola; Ambrosio, Antonio] Univ Foggia, Dept Med & Surg Sci, Foggia, Italy.
   [Pisanelli, Daniela] Riuniti Hosp, Foggia, Italy.
   [Asmundo, Alessio] Univ Messina, Sect Legal Med, Dept Biomed & Dent Sci & Morphol & Funct Images, Messina, Italy.
   [di Nunno, Nunzio] Univ Salento, Lecce, Italy.
   [Ametta, Alberto] Univ Foggia, Dept Econ, Foggia, Italy.
   [Francavilla, Vincenzo Cristian] Kore Univ Enna, Sch Engn Architecture & Motor Sci, Enna, Italy.
C3 Universita della Campania Vanvitelli; Universita della Campania
   Vanvitelli; University of Foggia; University of Foggia; University of
   Messina; University of Salento; University of Foggia; Universita Kore di
   ENNA
RP Polito, R (corresponding author), Univ Foggia, Dept Clin & Expt Med, Foggia, Italy.
EM rita.polito@unifg.it
RI Villano, Ines/ABU-5527-2022; Di Maio, Girolamo/HJI-6834-2023; MESSINA,
   ANTONIETTA/K-9366-2016; Di Nunno, Nunzio/L-6907-2015; Tartaglia,
   Nicola/AAD-7321-2019
OI Di Nunno, Nunzio/0000-0001-9409-1369; Di Maio,
   Girolamo/0000-0001-6305-2092; Francavilla, Vincenzo
   Cristian/0000-0002-7337-392X; VILLANO, INES/0000-0002-1755-358X;
   Tartaglia, Nicola/0000-0001-6845-7080; Monda,
   Marcellino/0000-0002-7184-218X
CR [Anonymous], 2013, CURR TOP TOXICOL
   Balkau B, 1999, DIABETIC MED, V16, P442
   BALLOR DL, 1991, INT J OBESITY, V15, P717
   Battaglia G, 2020, SUSTAINABILITY-BASEL, V12, DOI 10.3390/su12072684
   Bertozzi G, 2018, MOL NEUROBIOL, V55, P5548, DOI 10.1007/s12035-017-0774-1
   Bianco A, 2018, SUSTAINABILITY-BASEL, V10, DOI 10.3390/su10061847
   BJORNTORP P, 1991, DIABETES CARE, V14, P1132, DOI 10.2337/diacare.14.12.1132
   Braschi A, 2012, ANN NONINVAS ELECTRO, V17, P95, DOI 10.1111/j.1542-474X.2012.00495.x
   Bullock VE, 2017, ANN HUM BIOL, V44, P230, DOI 10.1080/03014460.2016.1232749
   Cardinal BJ, 2015, J PHYS ACT HEALTH, V12, P1336, DOI 10.1123/jpah.2014-0316
   CARTEE GD, 1991, J APPL PHYSIOL, V70, P1593, DOI 10.1152/jappl.1991.70.4.1593
   Chieffi S, 2017, FRONT NEUROL, V8, DOI 10.3389/fneur.2017.00188
   Cianci P, 2016, ANN ITAL CHIR, V87, P242
   Cianciulli A, 2017, CYTOKINE GROWTH F R, V37, P67, DOI 10.1016/j.cytogfr.2017.07.005
   Cianciulli A, 2016, MEDIAT INFLAMM, V2016, DOI 10.1155/2016/5240127
   Davidson LE, 2009, ARCH INTERN MED, V169, P122, DOI 10.1001/archinternmed.2008.558
   Després JP, 2008, ARTERIOSCL THROM VAS, V28, P1039, DOI 10.1161/ATVBAHA.107.159228
   DOUEN AG, 1990, J BIOL CHEM, V265, P13427
   Dunn AL, 1998, AM J PREV MED, V15, P398, DOI 10.1016/S0749-3797(98)00084-1
   Edwardson Charlotte L, 2012, PLOS ONE, V7, P4
   Fineschi V, 2006, INT J LEGAL MED, V120, P293, DOI 10.1007/s00414-006-0104-z
   Francavilla CV, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00153
   Francavilla G, 2013, Med Sport, V66, P625
   Francavilla G, 2007, MONADI ARCH CHEST DI, P87, DOI 10.4081/monaldi.2007.457
   Francavilla VC, 2015, MED SPORT, V68, P323
   FRANCAVILLA VC, 2018, FRONT PHYSIOL, V9, DOI DOI 10.3389/FPHYS.2018.00153
   Francavilla VC, 2017, MED SPORT, V70, P247, DOI 10.23736/S0025-7826.17.03037-X
   Francavilla VC, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01828
   Gremeaux V, 2012, AM J PHYS MED REHAB, V91, P941, DOI 10.1097/PHM.0b013e3182643ce0
   Healy GN, 2007, DIABETES CARE, V30, P1384, DOI 10.2337/dc07-0114
   Henriksen Erik J, 2002, J APPL PHYSIOL, V93, P788
   HUTTUNEN JK, 1979, CIRCULATION, V60, P1220, DOI 10.1161/01.CIR.60.6.1220
   Iqbal SP, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0224054
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Kandror KV, 1996, AM J PHYSIOL-ENDOC M, V271, pE1, DOI 10.1152/ajpendo.1996.271.1.E1
   KATZEL LI, 1995, JAMA-J AM MED ASSOC, V274, P1915, DOI 10.1001/jama.274.24.1915
   Kelley DE, 2001, MED SCI SPORT EXER, V33, pS495, DOI 10.1097/00005768-200106001-00020
   Kohl HW, 2001, MED SCI SPORT EXER, V33, pS472, DOI 10.1097/00005768-200106001-00017
   Laaksonen David E, 2003, DIABETES CARE, V26, P2156
   Lacedonia D, 2016, INT J CHRONIC OBSTR, V11, P527, DOI 10.2147/COPD.S99547
   Lakka TA, 2003, MED SCI SPORT EXER, V35, P1279, DOI 10.1249/01.MSS.0000079076.74931.9A
   Ledda C, 2017, MOL MED REP, V15, P511, DOI 10.3892/mmr.2016.6046
   Ledda C, 2016, ENVIRON RES, V150, P23, DOI 10.1016/j.envres.2016.05.024
   Matthews CE, 2008, AM J EPIDEMIOL, V167, P875, DOI 10.1093/aje/kwm390
   Mauri E, 2018, BIOMATER SCI-UK, V6, P501, DOI 10.1039/c7bm01056g
   Messina A, 2018, FRONT NEUROL, V9, DOI 10.3389/fneur.2018.00095
   Messina G., 2015, Biology and Medicine, V7, P1
   Moscatelli F., 2015, BIOL MED PARIS, V7, pS3008
   Moscatelli F, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0155998
   Mota Maria, 2004, Rom J Intern Med, V42, P247
   Neri NI, 2016, MEDIAT INFLAMM, DOI [10.1155/201613423450, DOI 10.1155/201613423450]
   Neri V, 2014, ANN ITAL CHIR, V85, P431
   Neri V, 2013, ANN ITAL CHIR, V84, P405
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Patti A, 2017, WORK, V57, P23, DOI 10.3233/WOR-172539
   Pedersen BK, 2015, SCAND J MED SCI SPOR, V25, P1, DOI 10.1111/sms.12581
   PEREIRA RC, 2019, INT J MOL SCI, V20, DOI DOI 10.1186/S12932-019-0063-1
   Ploug T, 1998, J CELL BIOL, V142, P1429, DOI 10.1083/jcb.142.6.1429
   Pomara C, 2005, INT J LEGAL MED, V119, P153, DOI 10.1007/s00414-004-0513-9
   Pomara C, 2015, CURR NEUROPHARMACOL, V13, P132, DOI 10.2174/1570159X13666141210221434
   Posa F, 2016, STEM CELLS INT, V2016, DOI 10.1155/2016/9150819
   Pricci M, 2009, TISSUE ENG PT A, V15, P137, DOI 10.1089/ten.tea.2007.0360
   Ridola Carlo Giuseppe, 2007, Italian Journal of Anatomy and Embryology, V112, P61
   Ritchie SA, 2007, NUTR METAB CARDIOVAS, V17, P319, DOI 10.1016/j.numecd.2006.07.005
   RUDERMAN NB, 1981, AM J CLIN NUTR, V34, P1617, DOI 10.1093/ajcn/34.8.1617
   Sanguedolce F, 2018, UROL INT, V101, P125, DOI 10.1159/000481576
   Seligman BGS, 2011, METABOLISM, V60, P1736, DOI 10.1016/j.metabol.2011.05.006
   Shin JA, 2013, J DIABETES INVEST, V4, P334, DOI 10.1111/jdi.12075
   Tartaglia N, 2016, OPEN MED-WARSAW, V11, P429, DOI 10.1515/med-2016-0078
   Telford RD, 2007, MED SCI SPORT EXER, V39, P1233, DOI 10.1249/mss.0b013e31806215b7
   TIMO A, 1994, NEW ENGL J MED, V330, P1549
   Trevisan M, 1998, AM J EPIDEMIOL, V148, P958
   Turillazzi E, 2013, FORENSIC SCI INT, V231, P142, DOI 10.1016/j.forsciint.2013.04.006
   Turillazzi E, 2008, VIRCHOWS ARCH, V453, P209, DOI 10.1007/s00428-008-0632-7
   Vicario N, 2019, MOL NEUROBIOL, V56, P7338, DOI 10.1007/s12035-019-1607-1
   Viggiano E, 2016, NEUROPSYCH DIS TREAT, V12, P1705, DOI 10.2147/NDT.S107074
   WHO, 2014, FACTSH WHO
   World Health Organization, 1999, WHONCINCS992
   Zdziarski LA, 2015, J PAIN RES, V8, P63, DOI 10.2147/JPR.S55360
NR 79
TC 9
Z9 9
U1 0
U2 6
PU CARBONE EDITORE
PI PALERMO
PA VIA QUINTINO SELLA, 68, PALERMO, 90139, ITALY
SN 0393-6384
EI 2283-9720
J9 ACTA MEDICA MEDITERR
JI Acta Medica Mediterr.
PY 2020
VL 36
IS 3
BP 1913
EP 1919
DI 10.19193/0393-6384_2020_3_299
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA LR5QL
UT WOS:000535749300101
DA 2025-06-11
ER

PT J
AU Alwahsh, SM
   Gebhardt, R
AF Alwahsh, Salamah Mohammad
   Gebhardt, Rolf
TI Dietary fructose as a risk factor for non-alcoholic fatty liver disease
   (NAFLD)
SO ARCHIVES OF TOXICOLOGY
LA English
DT Review
DE Insulin resistance; Inflammation; Metabolic syndrome (MetS); Gut
   microbiota; Herbal medicine; Biomarkers; The brain; Ethanol; Humans;
   Oxidative stress; Liver regeneration; ATP
ID INDUCED INSULIN-RESISTANCE; INDUCED HEPATIC STEATOSIS;
   PLASMINOGEN-ACTIVATOR INHIBITOR-1; NECROSIS-FACTOR-ALPHA; CONDITIONED
   FLAVOR PREFERENCES; URIC-ACID; OXIDATIVE STRESS; METABOLIC SYNDROME;
   SWEETENED BEVERAGES; LIPID-ACCUMULATION
AB Glucose is a major energy source for the entire body, while fructose metabolism occurs mainly in the liver. Fructose consumption has increased over the last decade globally and is suspected to contribute to the increased incidence of non-alcoholic fatty liver disease (NAFLD). NAFLD is a manifestation of metabolic syndrome affecting about one-third of the population worldwide and has progressive pathological potential for liver cirrhosis and cancer through non-alcoholic steatohepatitis (NASH). Here we have reviewed the possible contribution of fructose to the pathophysiology of NAFLD. We critically summarize the current findings about several regulators, and their potential mechanisms, that have been studied in humans and animal models in response to fructose exposure. A novel hypothesis on fructose-dependent perturbation of liver regeneration and metabolism is advanced. Fructose intake could affect inflammatory and metabolic processes, liver function, gut microbiota, and portal endotoxin influx. The role of the brain in controlling fructose ingestion and the subsequent development of NAFLD is highlighted. Although the importance for fructose (over)consumption for NAFLD in humans is still debated and comprehensive intervention studies are invited, understanding of how fructose intake can favor these pathological processes is crucial for the development of appropriate noninvasive diagnostic and therapeutic approaches to detect and treat these metabolic effects. Still, lifestyle modification, to lessen the consumption of fructose-containing products, and physical exercise are major measures against NAFLD. Finally, promising drugs against fructose-induced insulin resistance and hepatic dysfunction that are emerging from studies in rodents are reviewed, but need further validation in human patients.
C1 [Alwahsh, Salamah Mohammad; Gebhardt, Rolf] Univ Leipzig, Inst Biochem, Fac Med, Johannisallee 30, D-04103 Leipzig, Germany.
   [Alwahsh, Salamah Mohammad] Univ Edinburgh, MCR Ctr Regenerat Med, 5 Little France Dr, Edinburgh EH16 4UU, Midlothian, Scotland.
C3 Leipzig University; University of Edinburgh
RP Alwahsh, SM; Gebhardt, R (corresponding author), Univ Leipzig, Inst Biochem, Fac Med, Johannisallee 30, D-04103 Leipzig, Germany.; Alwahsh, SM (corresponding author), Univ Edinburgh, MCR Ctr Regenerat Med, 5 Little France Dr, Edinburgh EH16 4UU, Midlothian, Scotland.
EM alwahsh.salamah@gmail.com; Rolf.Gebhardt@medizin.uni-leipzig.de
FU Bundesministerium fur Forschung und Technologie (BMBF) [0315735]
FX This study was supported by grants from the Bundesministerium fur
   Forschung und Technologie (BMBF) in the framework of the Systems Biology
   initiative "Virtual Liver Network" to RG (Grant: 0315735).
CR Abdelmalek MF, 2012, HEPATOLOGY, V56, P952, DOI 10.1002/hep.25741
   Abdelmalek MF, 2010, HEPATOLOGY, V51, P1961, DOI 10.1002/hep.23535
   Agrawal R, 2016, J CEREBR BLOOD F MET, V36, P941, DOI 10.1177/0271678X15606719
   Ahmad S, 2014, SHOCK, V41, P337, DOI 10.1097/SHK.0000000000000107
   Al-Busafi Said A, 2012, Hepat Res Treat, V2012, P947575, DOI 10.1155/2012/947575
   Albuquerque D, 2014, ANN HUM GENET, V78, P195, DOI 10.1111/ahg.12058
   Alwahsh SM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0104220
   Alwahsh SM, 2014, WORLD J GASTROENTERO, V20, P1807, DOI 10.3748/wjg.v20.i7.1807
   Alwahsh SM, 2015, J OBES WEIGHT LOSS T, V5, P5, DOI [10.4172/2165-7904.1000280, DOI 10.4172/2165-7904.1000280]
   Aron-Wisnewsky J, 2013, CLIN MICROBIOL INFEC, V19, P338, DOI 10.1111/1469-0691.12140
   Aroor AR, 2015, DIABETES, V64, P1988, DOI 10.2337/db14-0804
   Assy N, 2008, CAN J GASTROENTEROL, V22, P811, DOI 10.1155/2008/810961
   Azhar A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0098281
   Bakoma B, 2014, J ETHNOPHARMACOL, V153, P896, DOI 10.1016/j.jep.2014.03.065
   Barker CE, 2014, IMMUNOLOGY, V143, P138, DOI 10.1111/imm.12332
   Basaranoglu M, 2015, HEPATOBIL SURG NUTR, V4, P109, DOI 10.3978/j.issn.2304-3881.2014.11.05
   Bellentani S, 2010, DIGEST DIS, V28, P155, DOI 10.1159/000282080
   Bergheim I, 2008, J HEPATOL, V48, P983, DOI 10.1016/j.jhep.2008.01.035
   Bettaieb A, 2014, FREE RADICAL BIO MED, V72, P247, DOI 10.1016/j.freeradbiomed.2014.04.011
   Birkenfeld AL, 2014, HEPATOLOGY, V59, P713, DOI 10.1002/hep.26672
   Boesch C, 1997, MAGN RESON IMAGING, V15, P1067, DOI 10.1016/S0730-725X(97)00163-X
   Borkham-Kamphorst E, 2011, LIVER INT, V31, P656, DOI 10.1111/j.1478-3231.2011.02495.x
   Bray GA, 2004, AM J CLIN NUTR, V79, P537
   Bray GA, 2014, DIABETES CARE, V37, P950, DOI 10.2337/dc13-2085
   BROWN SS, 1972, LANCET, V2, P898
   Butler AA, 2015, SCI REP-UK, V5, DOI 10.1038/srep14691
   Carvalhana S, 2012, CURR OPIN CLIN NUTR, V15, P468, DOI 10.1097/MCO.0b013e3283566614
   Cha SH, 2008, P NATL ACAD SCI USA, V105, P16871, DOI 10.1073/pnas.0809255105
   Charlton M, 2011, AM J PHYSIOL-GASTR L, V301, pG825, DOI 10.1152/ajpgi.00145.2011
   Chung M, 2014, AM J CLIN NUTR, V100, P833, DOI 10.3945/ajcn.114.086314
   Clayton ZE, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0141962
   Conlon BA, 2013, NUTRIENTS, V5, P4093, DOI 10.3390/nu5104093
   Cortez-Pinto H, 1999, JAMA-J AM MED ASSOC, V282, P1659, DOI 10.1001/jama.282.17.1659
   Cox CL, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-68
   Crescenzo R, 2013, EUR J NUTR, V52, P537, DOI 10.1007/s00394-012-0356-y
   Dam-Larsen S, 2004, GUT, V53, P750, DOI 10.1136/gut.2003.019984
   DeBosch BJ, 2014, J BIOL CHEM, V289, P10989, DOI 10.1074/jbc.M113.527002
   Di Luccia B, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0134893
   Downing LE, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0140267
   Dupas J, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0146821
   Edmison John, 2007, Clin Liver Dis, V11, P75, DOI 10.1016/j.cld.2007.02.011
   Ekstedt M, 2006, HEPATOLOGY, V44, P865, DOI 10.1002/hep.21327
   Engstler AJ, 2016, GUT, V65, P1564, DOI 10.1136/gutjnl-2014-308379
   Erlanson-Albertsson C, 2010, REGUL PEPTIDES, V161, P87, DOI 10.1016/j.regpep.2010.01.003
   Feige JN, 2008, CELL METAB, V8, P347, DOI 10.1016/j.cmet.2008.08.017
   Fernández-Novell JM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0109726
   Frank DN, 2007, P NATL ACAD SCI USA, V104, P13780, DOI 10.1073/pnas.0706625104
   Gebhardt R, 2014, WORLD J GASTROENTERO, V20, P8491, DOI 10.3748/wjg.v20.i26.8491
   Giris M, 2014, J PHYSIOL BIOCHEM, V70, P385, DOI 10.1007/s13105-014-0314-7
   Gorden DL, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0022775
   Guimaraes PS, 2014, HYPERTENSION, V63, P1078, DOI 10.1161/HYPERTENSIONAHA.113.01847
   Guo H, 2010, DIABETES, V59, P1376, DOI 10.2337/db09-1735
   Hirahatake KM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026583
   Ishimoto T, 2013, HEPATOLOGY, V58, P1632, DOI 10.1002/hep.26594
   Johnson RJ, 2013, DIABETES, V62, P3307, DOI 10.2337/db12-1814
   Johnston RD, 2013, GASTROENTEROLOGY, V145, P1016, DOI 10.1053/j.gastro.2013.07.012
   Kanuri G, 2011, LAB INVEST, V91, P885, DOI 10.1038/labinvest.2011.44
   Kanuri G, 2011, J NUTR BIOCHEM, V22, P527, DOI 10.1016/j.jnutbio.2010.04.007
   Kavanagh K, 2013, AM J CLIN NUTR, V98, P349, DOI 10.3945/ajcn.112.057331
   Kawasaki T, 2009, J NUTR, V139, P2067, DOI 10.3945/jn.109.105858
   Kelishadi R, 2014, NUTRITION, V30, P503, DOI 10.1016/j.nut.2013.08.014
   Koliaki C, 2013, MOL CELL ENDOCRINOL, V379, P35, DOI 10.1016/j.mce.2013.06.002
   KORIEH A, 1991, ARCH INT PHYSIOL BIO, V99, P455
   Lanaspa MA, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3434
   Lanaspa MA, 2012, J BIOL CHEM, V287, P40732, DOI 10.1074/jbc.M112.399899
   Lanaspa MA, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0047948, 10.1371/journal.pone.0048801]
   Latta M, 2007, J PHARMACOL EXP THER, V321, P875, DOI 10.1124/jpet.107.119958
   Lettner A, 2008, CURR DIABETES REP, V8, P185, DOI 10.1007/s11892-008-0032-z
   Li JM, 2015, MOL NUTR FOOD RES, V59, P189, DOI 10.1002/mnfr.201400307
   Li ML, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076961
   Li YG, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0111707
   Lim JS, 2010, NAT REV GASTRO HEPAT, V7, P251, DOI 10.1038/nrgastro.2010.41
   Lin HZ, 2000, NAT MED, V6, P998, DOI 10.1038/79697
   Lindqvist A, 2008, REGUL PEPTIDES, V150, P26, DOI 10.1016/j.regpep.2008.06.008
   Liu J, 2014, FOOD FUNCT, V5, P1038, DOI 10.1039/c3fo60524h
   Liu XJ, 2014, BIOCHEM BIOPH RES CO, V450, P117, DOI 10.1016/j.bbrc.2014.05.072
   Lou PH, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011669
   Lustig RH, 2010, J AM DIET ASSOC, V110, P1307, DOI 10.1016/j.jada.2010.06.008
   Mahli A, 2015, ONCOTARGET, V6, P41464, DOI 10.18632/oncotarget.6203
   Makki K, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0092684
   Malkusz DC, 2015, BRAIN RES, V1596, P116, DOI 10.1016/j.brainres.2014.11.028
   Marriott BP, 2009, J NUTR, V139, pS1228, DOI 10.3945/jn.108.098277
   Martius G, 2014, INT J CLIN EXP PATHO, V7, P5379
   Mate A, 2001, CELL MOL LIFE SCI, V58, P1961, DOI 10.1007/PL00000830
   Matz-Soja M, 2016, ELIFE, V5, DOI 10.7554/eLife.13308
   Michael MD, 2000, MOL CELL, V6, P87, DOI 10.1016/S1097-2765(00)00010-1
   Montonen J, 2007, J NUTR, V137, P1447, DOI 10.1093/jn/137.6.1447
   Morishita S, 2013, J OLEO SCI, V62, P97, DOI 10.5650/jos.62.97
   Mortensen OH, 2014, J CEREBR BLOOD F MET, V34, P1205, DOI 10.1038/jcbfm.2014.72
   Mouzaki M, 2013, HEPATOLOGY, V58, P120, DOI 10.1002/hep.26319
   Mukai Y, 2014, CLIN EXP PHARMACOL P, V41, P331, DOI 10.1111/1440-1681.12225
   Nair S, 2004, ALIMENT PHARM THERAP, V20, P23, DOI 10.1111/j.1365-2036.2004.02025.x
   Nair S, 2003, AM J GASTROENTEROL, V98, P466, DOI 10.1016/S0002-9270(02)05889-6
   Nakagawa T, 2006, AM J PHYSIOL-RENAL, V290, pF625, DOI 10.1152/ajprenal.00140.2005
   Nan YM, 2014, WORLD J GASTROENTERO, V20, P8055, DOI 10.3748/wjg.v20.i25.8055
   Narasimhan A, 2015, EUR J PHARMACOL, V761, P391, DOI 10.1016/j.ejphar.2015.04.043
   Niklas J, 2012, BMB REP, V45, P396, DOI 10.5483/BMBRep.2012.45.7.070
   Okada E, 1999, DIABETES CARE, V22, P484, DOI 10.2337/diacare.22.3.484
   Onyesom I, 2005, ANN NUTR METAB, V49, P319, DOI 10.1159/000087336
   Oron-Herman M, 2003, METABOLISM, V52, P1491, DOI 10.1016/S0026-0495(03)00262-2
   Ouyang X, 2008, J HEPATOL, V48, P993, DOI 10.1016/j.jhep.2008.02.011
   Page KA, 2013, JAMA-J AM MED ASSOC, V309, P63, DOI 10.1001/jama.2012.116975
   Pastoret A, 2013, ARCH TOXICOL, V87, P1001, DOI 10.1007/s00204-012-0948-6
   Pessayre D, 2005, J HEPATOL, V42, P928, DOI 10.1016/j.jhep.2005.03.004
   Petrie JL, 2013, AM J PHYSIOL-ENDOC M, V305, pE1255, DOI 10.1152/ajpendo.00214.2013
   Petta S, 2013, J HEPATOL, V59, P1169, DOI 10.1016/j.jhep.2013.07.037
   Prakash P, 2014, EUR J PHARMACOL, V727, P15, DOI 10.1016/j.ejphar.2014.01.038
   Pyo YH, 2014, J MED FOOD, V17, P826, DOI 10.1089/jmf.2013.3001
   Qu HE, 2014, MOL BIOL REP, V41, P3245, DOI 10.1007/s11033-014-3187-5
   Raatz SK, 2015, J NUTR, V145, P2265, DOI 10.3945/jn.115.218016
   Rashid A, 1999, HEPATOLOGY, V29, P1131, DOI 10.1002/hep.510290428
   Rebollo A, 2014, BBA-MOL CELL BIOL L, V1841, P514, DOI 10.1016/j.bbalip.2014.01.002
   Ren DY, 2014, FOOD FUNCT, V5, P2609, DOI 10.1039/c3fo60640f
   Ren LP, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030816
   Renaud HJ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0088584
   RIBY JE, 1993, AM J CLIN NUTR, V58, P748, DOI 10.1093/ajcn/58.5.748S
   Ritze Y, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0101702
   Rivera FP, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059253
   Rodrigues DF, 2014, J NUTR BIOCHEM, V25, P388, DOI 10.1016/j.jnutbio.2013.11.012
   Rokutan M, 2015, ENDOCR J, V62, P1025, DOI 10.1507/endocrj.EJ14-0590
   Rorabaugh JM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0095019
   Rovenko BM, 2015, COMP BIOCHEM PHYS A, V180, P75, DOI 10.1016/j.cbpa.2014.11.008
   Sakar Y, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007935
   Samuel VT, 2004, J BIOL CHEM, V279, P32345, DOI 10.1074/jbc.M313478200
   Sapp V, 2014, HEPATOLOGY, V60, P1581, DOI 10.1002/hep.27284
   Saravanan M, 2014, EUR J PHARMACOL, V740, P714, DOI 10.1016/j.ejphar.2014.06.004
   SCHOLZ R, 1976, EUR J BIOCHEM, V63, P449, DOI 10.1111/j.1432-1033.1976.tb10247.x
   Schwarz JM, 2015, J CLIN ENDOCR METAB, V100, P2434, DOI 10.1210/jc.2014-3678
   SCLAFANI A, 1994, PHYSIOL BEHAV, V56, P399, DOI 10.1016/0031-9384(94)90213-5
   Sharma S, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025269
   Shawky NM, 2014, EUR J PHARMACOL, V740, P353, DOI 10.1016/j.ejphar.2014.07.021
   Shi PY, 2015, BMC COMPLEM ALTERN M, V15, DOI 10.1186/s12906-015-0766-5
   Shulga N, 2014, J CELL SCI, V127, P896, DOI 10.1242/jcs.140764
   Sloboda Deborah M, 2014, J Obes, V2014, P203474, DOI 10.1155/2014/203474
   Soleimani M, 2011, ACTA PHYSIOL, V201, P55, DOI 10.1111/j.1748-1716.2010.02167.x
   Song M, 2016, ALCOHOL CLIN EXP RES, V40, P518, DOI 10.1111/acer.12994
   Song M, 2012, J HEPATOL, V56, P433, DOI 10.1016/j.jhep.2011.05.030
   Speicher T, 2012, J BIOL CHEM, V287, P1837, DOI 10.1074/jbc.M111.266742
   Spruss A, 2012, MOL MED, V18, P1346, DOI 10.2119/molmed.2012.00223
   Spruss A, 2012, LAB INVEST, V92, P1020, DOI 10.1038/labinvest.2012.75
   Spruss A, 2011, ANTIOXID REDOX SIGN, V14, P2121, DOI 10.1089/ars.2010.3263
   Spruss A, 2009, HEPATOLOGY, V50, P1094, DOI 10.1002/hep.23122
   Stanhope KL, 2009, J CLIN INVEST, V119, P1322, DOI 10.1172/JCI37385
   Suwannaphet W, 2010, FOOD CHEM TOXICOL, V48, P1853, DOI 10.1016/j.fct.2010.04.021
   Tappy L, 2013, NUTR METAB, V10, DOI 10.1186/1743-7075-10-54
   Thuy S, 2008, J NUTR, V138, P1452, DOI 10.1093/jn/138.8.1452
   Tilg H, 2017, NAT REV GASTRO HEPAT, V14, P32, DOI 10.1038/nrgastro.2016.147
   Tiniakos DG, 2010, ANNU REV PATHOL-MECH, V5, P145, DOI 10.1146/annurev-pathol-121808-102132
   Tomita K, 2006, GUT, V55, P415, DOI 10.1136/gut.2005.071118
   Uzuegbu UE, 2009, CR BIOL, V332, P534, DOI 10.1016/j.crvi.2009.01.007
   Vilà L, 2011, TOXICOL APPL PHARM, V251, P32, DOI 10.1016/j.taap.2010.11.011
   Volynets V, 2013, EUR J NUTR, V52, P527, DOI 10.1007/s00394-012-0355-z
   Volynets V, 2010, J LIPID RES, V51, P3414, DOI 10.1194/jlr.M007179
   Vos Miriam B, 2008, Medscape J Med, V10, P160
   Weiland T, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0052496
   Welsh JA, 2011, AM J CLIN NUTR, V94, P726, DOI 10.3945/ajcn.111.018366
   White JS, 2008, AM J CLIN NUTR, V88, p1716S, DOI 10.3945/ajcn.2008.25825B
   Wigg AJ, 2001, GUT, V48, P206, DOI 10.1136/gut.48.2.206
   Xu M, 2016, J SURG RES, V203, P222, DOI 10.1016/j.jss.2013.12.019
   Xu MX, 2016, BRAIN BEHAV IMMUN, V58, P69, DOI 10.1016/j.bbi.2016.01.001
   Xu TT, 2014, ARCH TOXICOL, V88, P739, DOI 10.1007/s00204-013-1148-8
   Yin QQ, 2014, NEUROPHARMACOLOGY, V86, P389, DOI 10.1016/j.neuropharm.2014.07.020
   Yki-Järvinen H, 2010, CURR OPIN CLIN NUTR, V13, P709, DOI 10.1097/MCO.0b013e32833f4b34
   Zhao Y, 2014, FOOD FUNCT, V5, P1771, DOI [10.1039/c3fo60707k, 10.1039/C3FO60707K]
   Zheng J, 2015, METAB BRAIN DIS, V30, P1129, DOI 10.1007/s11011-015-9678-9
   Zhong W, 2015, J HEPATOL, V62, P1375, DOI [10.1016/j.jhep.2015.02.011, 10.1016/j.jhep.2014.12.022]
NR 166
TC 106
Z9 115
U1 5
U2 91
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0340-5761
EI 1432-0738
J9 ARCH TOXICOL
JI Arch. Toxicol.
PD APR
PY 2017
VL 91
IS 4
BP 1545
EP 1563
DI 10.1007/s00204-016-1892-7
PG 19
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA ER5CO
UT WOS:000398819200002
PM 27995280
DA 2025-06-11
ER

PT J
AU Conti, A
   Vanni, S
   Sammicheli, L
   Raveggi, S
   Camaiti, A
   Pieralli, F
   Nozzoli, C
   Gallini, C
   Costanzo, E
   Gensini, GF
AF Conti, Alberto
   Vanni, Simone
   Sammicheli, Lucia
   Raveggi, Serena
   Camaiti, Alberto
   Pieralli, Filippo
   Nozzoli, Carlo
   Gallini, Chiara
   Costanzo, Egidio
   Gensini, Gian Franco
TI Yield of nuclear scan strategy in chest pain unit evaluation of special
   populations
SO NUCLEAR MEDICINE COMMUNICATIONS
LA English
DT Article
DE chest pain; chest pain unit; coronary artery disease; diabetes mellitus;
   exercise stress testing; metabolic syndrome; myocardial perfusion
   imaging
ID EMISSION COMPUTED-TOMOGRAPHY; AMERICAN-HEART-ASSOCIATION;
   CORONARY-ARTERY-DISEASE; ST-SEGMENT ELEVATION; METABOLIC SYNDROME;
   EMERGENCY-ROOM; STRESS ECHOCARDIOGRAPHY; MYOCARDIAL-INFARCTION;
   CLINICAL-CARDIOLOGY; PROGNOSTIC VALUE
AB Background Patients with chest pain (CP) and nondiagnostic ECG represent heterogeneous population in whom the evaluation of coronary risk factors including metabolic syndrome (MetS) and diabetes mellitus (DM) might improve risk stratification.
   Methods We enrolled 798 consecutive CP patients; 14% presented with MetS and 10% with DM; the remaining 76% presented with other coronary risk profiles (others). All patients underwent maximal exercise tolerance test (ETT) and myocardial perfusion imaging (exercise-MPI). Those with positive testing underwent angiography, whereas the remaining patients were discharged and later followed up. Primary end-point was a composite of coronary stenoses greater than or equal to 50% documented by angiography or coronary events at follow-up.
   Results Patients with MetS or DM had significantly lower survival free from end-point than those patients without (P < 0.001). Exercise-MPI showed high negative predictive value in MetS, DM, and others (> 96%); however, positive predictive value was 69, 74, and 52%, respectively (P < 0.05). ETT alone showed negative predictive value (88%) which was significantly lower than exercise-MPI (98%), (MetS vs. others: P < 0.001, and DM vs. others: P=0.05). The area under the receiver-operating characteristic curves obtained from the multivariate model includes clinical data alone, clinical data and ETT results, or clinical data and exercise-MPI results increase progressively.
   Conclusion A nuclear scan strategy in special populations, including CP patients with MetS or DM, is a valuable tool for risk stratification and adds incremental prognostic value over clinical and ETT values. Nucl Med Commun 29:1106-1112 (c) 2008 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Conti, Alberto; Vanni, Simone; Sammicheli, Lucia; Raveggi, Serena; Camaiti, Alberto; Pieralli, Filippo; Nozzoli, Carlo] Careggi Univ Hosp, Emergency Med & Chest Pain Unit, Florence, Italy.
C3 University of Florence; Azienda Ospedaliero Universitaria Careggi
RP Conti, A (corresponding author), Viale Matteotti 21, I-50121 Florence, Italy.
EM aaaconti@hotmail.com
RI Vanni, Simone/GLR-6148-2022; Pieralli, Filippo/HJH-9760-2023
OI Vanni, Simone/0000-0002-1201-5715; Pieralli, Filippo/0000-0002-1016-7432
CR Alexander CM, 2003, DIABETES, V52, P1210, DOI 10.2337/diabetes.52.5.1210
   Bholasingh R, 2003, J AM COLL CARDIOL, V41, P596, DOI 10.1016/S0735-1097(02)02897-8
   Braunwald E, 2000, J AM COLL CARDIOL, V36, P970, DOI 10.1016/S0735-1097(00)00889-5
   Conti A, 2005, AM HEART J, V149, P894, DOI 10.1016/j.ahj.2004.09.048
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Fox K, 2006, EUR HEART J, V27, P1341, DOI 10.1093/eurheartj/ehl001
   Giri S, 2002, CIRCULATION, V105, P32, DOI 10.1161/hc5001.100528
   Hachamovitch R, 2002, CIRCULATION, V105, P823, DOI 10.1161/hc0702.103973
   HERHARDT L, 2002, EUR HEART J, V23, P1153
   Kapetanopoulos A, 2004, J NUCL CARDIOL, V11, P570, DOI 10.1016/j.nuclcard.2004.05.007
   Kontos MC, 2004, J AM COLL CARDIOL, V43, P958, DOI 10.1016/j.jacc.2003.10.036
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lee TH, 2000, NEW ENGL J MED, V342, P1187, DOI 10.1056/NEJM200004203421607
   Mieres JH, 2005, CIRCULATION, V111, P682, DOI 10.1161/01.CIR.0000155233.67287.60
   Miller TD, 2004, AM HEART J, V147, P890, DOI 10.1016/j.ahj.2003.08.015
   Morise A, 2007, HEART, V93, P200, DOI 10.1136/hrt.2006.093799
   PEELS CH, 1990, AM J CARDIOL, V65, P687, DOI 10.1016/0002-9149(90)90143-O
   Ramsay G, 2007, QJM-INT J MED, V100, P11, DOI 10.1093/qjmed/hcl133
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   Shaw LJ, 2000, AM J CARDIOL, V86, P1, DOI 10.1016/S0002-9149(00)00819-5
   Stein RA, 2000, CIRCULATION, V102, P1463, DOI 10.1161/01.CIR.102.12.1463
   Udelson JE, 2002, JAMA-J AM MED ASSOC, V288, P2693, DOI 10.1001/jama.288.21.2693
   Van de Werf F, 2003, EUR HEART J, V24, P28, DOI 10.1016/S0195-668X(02)00618-8
   Wackers FJT, 2002, J NUCL CARDIOL, V9, P246, DOI 10.1067/mnc.2002.122630
   Wackers FJT, 2004, DIABETES CARE, V27, P1954, DOI 10.2337/diacare.27.8.1954
NR 25
TC 8
Z9 8
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0143-3636
EI 1473-5628
J9 NUCL MED COMMUN
JI Nucl. Med. Commun.
PD DEC
PY 2008
VL 29
IS 12
BP 1106
EP 1112
DI 10.1097/MNM.0b013e328310b361
PG 7
WC Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Radiology, Nuclear Medicine & Medical Imaging
GA 376DU
UT WOS:000261164200013
PM 18987533
DA 2025-06-11
ER

PT J
AU Shoier, NO
   Ghareib, SA
   Kothayer, H
   Alsemeh, AE
   El-Sayed, SS
AF Shoier, Nourhan O.
   Ghareib, Salah A.
   Kothayer, Hend
   Alsemeh, Amira Ebrahim
   El-Sayed, Shaimaa S.
TI Vitamin D3 mitigates myopathy and metabolic dysfunction in rats with
   metabolic syndrome: the potential role of dipeptidyl peptidase-4
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Vitamin D3; Metabolic syndrome; Myopathy; DPP-4 inhibitors;
   Vildagliptin; Skeletal muscles
ID GLYCATION END-PRODUCTS; SKELETAL-MUSCLE; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; D SUPPLEMENTATION; BLOOD-PRESSURE; HIGHLY POTENT; FRUCTOSE;
   VILDAGLIPTIN; ASSOCIATION
AB Metabolic syndrome is associated with vitamin D3 deficiency. This work aims to examine the efficacy of vitamin D3 in inhibiting MetS-induced myopathy and to determine whether the beneficial effects of vitamin D3 are mediated by the inhibition of dipeptidyl peptidase-4 (DPP-4). An in silico study investigated the potential effectiveness of vitamin D3 on the inhibition of the DPP-4 enzyme. An in vitro assay of the DPP-4 inhibitory effect of vitamin D3 was performed. In vivo and over 12 weeks, both diet (with 3% salt) and drinking water (with 10% fructose) were utilized to induce MetS. In the seventh week, rats received either vitamin D3, vildagliptin, a combination of both, or vehicles. Serum lipids, adipokines, glycemic indices, and glucagon-like peptide-1 (GLP-1), muscular glucose transporter type-4 (GLUT-4) content, DPP-4, adenosine monophosphate kinase (AMPK) activities, and Sudan Black B-stained lipids were assessed. Muscular reactive oxygen species (ROS), caspase-3, and desmin immunostaining were used to determine myopathy. MetS-induced metabolic dysfunction was ameliorated by vitamin D3, which also reduced intramuscular glycogen and lipid accumulation. This is demonstrated by the attenuation of MetS-induced myopathy by vitamin D3, decreased oxidative stress, increased desmin immuno-expression, and caspase-3 activity. Our in silico data demonstrated that vitamin D3 is capable of inhibiting DPP-4, which is further supported by biochemical findings. Vitamin D3 increased serum GLP-1, muscular AMPK activity, and GLUT-4 content, whereas the levels of muscular ROS were decreased in MetS. Vildagliptin and its combination with vitamin D3 yielded comparable results. It is suggested that the DPP-4 inhibitory potential of vitamin D3 is responsible for the amelioration of MetS-induced metabolic changes and myopathy.
C1 [Shoier, Nourhan O.; Ghareib, Salah A.; El-Sayed, Shaimaa S.] Zagazig Univ, Fac Pharm, Pharmacol & Toxicol Dept, Zagazig 44519, Egypt.
   [Kothayer, Hend] Zagazig Univ, Fac Pharm, Med Chem Dept, Zagazig, Egypt.
   [Alsemeh, Amira Ebrahim] Zagazig Univ, Fac Med, Human Anat & Embryol Dept, Zagazig, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Egyptian Knowledge
   Bank (EKB); Zagazig University; Egyptian Knowledge Bank (EKB); Zagazig
   University
RP El-Sayed, SS (corresponding author), Zagazig Univ, Fac Pharm, Pharmacol & Toxicol Dept, Zagazig 44519, Egypt.
EM n.omoustafa22@pharmacy.zu.edu.eg; salahatteiah@pharmacy.zu.edu.eg;
   Hendo1311@hotmail.com; Aialsemeh@zu.edu.eg; ssothman@pharmacy.zu.edu.eg
RI El-Sayed, Shaimaa/HJB-0866-2022; Atteiah, salah/I-1537-2012; Kothayer,
   Hend/GRJ-5827-2022; Alsemeh, Amira/LWH-9728-2024
OI O.Shoier, Nourhan/0000-0002-4562-2191; El-Sayed,
   Shaimaa/0000-0003-2314-6144
FU Zagazig University
FX Acknowledgement We thank Dr. Marwa Abolfotouh for assissting with
   proofreading.
CR Abd Allah A.L., 2021, Egypt J Food Sci, V49, P19, DOI [10.21608/ejfs.2021.44711.1081, DOI 10.21608/EJFS.2021.44711.1081]
   Abdelhedi O, 2019, MAR DRUGS, V17, DOI 10.3390/md17040194
   Ahrén B, 2011, DIABETES OBES METAB, V13, P775, DOI 10.1111/j.1463-1326.2011.01414.x
   Baradaran A, 2012, ENDOKRYNOL POL, V63, P29
   Berger JP, 2018, ENDOCRIN DIAB METAB, V1, DOI 10.1002/edm2.2
   Boschmann M, 2009, J CLIN ENDOCR METAB, V94, P846, DOI 10.1210/jc.2008-1400
   Boyer F, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/534873
   Bozkurt O, 2010, ANALYST, V135, P3110, DOI 10.1039/c0an00542h
   Cambri LT, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-118
   Chan AML, 2021, NUTRIENTS, V13, DOI 10.3390/nu13082497
   Chang E, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112806
   Chen CC, 2019, BMC CARDIOVASC DISOR, V19, DOI 10.1186/s12872-019-01275-5
   Chen W, 2014, METABOLISM, V63, P150, DOI 10.1016/j.metabol.2013.09.018
   CHIFFELLE TL, 1951, STAIN TECHNOL, V26, P51, DOI 10.3109/10520295109113178
   Coletta DK, 2011, AM J PHYSIOL-ENDOC M, V301, pE749, DOI 10.1152/ajpendo.00363.2011
   Collins KH, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00112
   Du WH, 2019, INT J CLIN EXP MED, V12, P11657
   Dzik KP, 2019, EUR J APPL PHYSIOL, V119, P825, DOI 10.1007/s00421-019-04104-x
   Eckhardt M, 2007, J MED CHEM, V50, P6450, DOI 10.1021/jm701280z
   El-Naggar AR, 2019, J CARDIOVASC PHARM T, V24, P254, DOI 10.1177/1074248418817345
   Er LK, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0149731
   Esposito K, 2004, NUTR METAB CARDIOVAS, V14, P228, DOI 10.1016/S0939-4753(04)80048-6
   Ferreira LF, 2016, FREE RADICAL BIO MED, V98, P18, DOI 10.1016/j.freeradbiomed.2016.05.011
   Ferreira PP, 2020, CLIMACTERIC, V23, P24, DOI [10.1007/s10111-019-00540-z, 10.1080/13697137.2019.1611761]
   Franklin Stanley S., 2006, Metabolic Syndrome and Related Disorders, V4, P287, DOI 10.1089/met.2006.4.287
   FRIEDEWALD WT, 1972, CLIN CHEM, V18
   Ghaderi A, 2017, PROG NEURO-PSYCHOPH, V79, P84, DOI 10.1016/j.pnpbp.2017.06.016
   Gilbert MP, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00178
   Gilsanz V, 2010, J CLIN ENDOCR METAB, V95, P1595, DOI 10.1210/jc.2009-2309
   Gordish KL, 2017, PHYSIOL REP, V5, DOI 10.14814/phy2.13162
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Helmy MM, 2019, PROSTAG OTH LIPID M, V141, P1, DOI 10.1016/j.prostaglandins.2019.01.001
   Herz CT, 2021, OBES SURG, V31, P2545, DOI 10.1007/s11695-020-05200-0
   Hua N, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0182430
   Kang JH, 2013, ENDOCRINOL METAB, V28, P96, DOI 10.3803/EnM.2013.28.2.96
   Khanal RC, 2010, FOOD FUNCT, V1, P116, DOI 10.1039/c0fo00089b
   Kilkenny C, 2010, J GENE MED, V12, P561, DOI [10.1113/jphysiol.2010.192278, 10.1002/jgm.1473, 10.1111/j.1476-5381.2010.00872.x]
   Kluck RM, 1999, J CELL BIOL, V147, P809, DOI 10.1083/jcb.147.4.809
   Kothayer H, 2019, DRUG DEVELOP RES, V80, P343, DOI 10.1002/ddr.21506
   Kumar S, 2021, BIOORGAN MED CHEM, V46, DOI 10.1016/j.bmc.2021.116354
   Levanovich PE, 2021, NUTRIENTS, V13, DOI 10.3390/nu13093129
   Li AJ, 2022, FOOD SCI TECH-BRAZIL, V42, DOI 10.1590/fst.47921
   Li N, 2018, EUR J MED CHEM, V151, P145, DOI 10.1016/j.ejmech.2018.03.041
   Li XG, 2011, HYPERTENS RES, V34, P869, DOI 10.1038/hr.2011.44
   Li YW, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-89307-z
   Lim JS, 2010, NAT REV GASTRO HEPAT, V7, P251, DOI 10.1038/nrgastro.2010.41
   Liu ML, 2014, BEST PRACT RES CL EN, V28, P25, DOI 10.1016/j.beem.2013.06.003
   Mai S, 2017, NUTRIENTS, V9, DOI 10.3390/nu9050459
   Maladkar M., 2016, J DIABETES MELLITUS, V6, P113, DOI [10.4236/jdm.2016.62012, DOI 10.4236/JDM.2016.62012]
   Manna P, 2017, ARCH BIOCHEM BIOPHYS, V615, P22, DOI 10.1016/j.abb.2017.01.002
   Masgrau A, 2012, J PHYSIOL-LONDON, V590, P5199, DOI 10.1113/jphysiol.2012.238576
   Mastrocola R, 2016, FREE RADICAL BIO MED, V91, P224, DOI 10.1016/j.freeradbiomed.2015.12.022
   Matikainen N, 2006, DIABETOLOGIA, V49, P2049, DOI 10.1007/s00125-006-0340-2
   Melguizo-Rodríguez L, 2021, NUTRIENTS, V13, DOI 10.3390/nu13030830
   Mohamed B, 2024, EUR J PHARMACOL, V973, DOI 10.1016/j.ejphar.2024.176605
   Montenegro KR, 2021, NUTRIENTS, V13, DOI 10.3390/nu13041110
   Moy FM, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-735
   Muscogiuri G, 2010, OBESITY, V18, P1906, DOI 10.1038/oby.2010.11
   Nabeno M, 2013, BIOCHEM BIOPH RES CO, V434, P191, DOI 10.1016/j.bbrc.2013.03.010
   Nimitphong H, 2021, J CLIN TRANSL ENDOCR, V24, DOI 10.1016/j.jcte.2021.100255
   Oh JY, 2002, METABOLISM, V51, P356, DOI 10.1053/meta.2002.29969
   Pashova-Stoyanova L., 2019, Trakia Journal of Sciences, V17, P277, DOI 10.15547/tjs.2019.03.017
   Paulin D, 2004, EXP CELL RES, V301, P1, DOI 10.1016/j.yexcr.2004.08.004
   Pinho RA, 2017, FREE RADICAL BIO MED, V110, P381, DOI 10.1016/j.freeradbiomed.2017.07.005
   Rault-Nania MH, 2008, CLIN NUTR, V27, P276, DOI 10.1016/j.clnu.2008.01.015
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Salum E, 2013, DIABETES RES CLIN PR, V100, P243, DOI 10.1016/j.diabres.2013.03.008
   Shimodaira M, 2015, ENDOCR METAB IMMUNE, V15, P223, DOI 10.2174/1871530315666150324114149
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Sona G, 1979, HYPERTENSION, DOI [10.5772/intechopen.102774, DOI 10.5772/INTECHOPEN.102774]
   Sweeney G, 2001, ENDOCRINOLOGY, V142, P4806, DOI 10.1210/en.142.11.4806
   Sylow L, 2021, CELL METAB, V33, P758, DOI 10.1016/j.cmet.2021.03.020
   Szymczak-Pajor I, 2019, NUTRIENTS, V11, DOI 10.3390/nu11040794
   ULC CCG, 2021, MOL OPERATING ENV MO
   Umek N, 2021, BOSNIAN J BASIC MED, V21, P729, DOI 10.17305/bjbms.2021.5876
   Varghese F, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0096801
   Varghese J, 2003, APOPTOSIS, V8, P363, DOI 10.1023/A:1024121017841
   Wahba NS, 2021, EUR J NUTR, V60, P299, DOI 10.1007/s00394-020-02249-6
   Wahba NS, 2020, EUR J PHARM SCI, V144, DOI 10.1016/j.ejps.2019.105196
   Wei X, 2021, DIABETOL METAB SYNDR, V13, DOI 10.1186/s13098-021-00703-x
   Wu C, 2017, MOL MED REP, V15, P4346, DOI 10.3892/mmr.2017.6501
   Wu HZ, 2017, J CLIN INVEST, V127, P43, DOI [10.1172/JCI88880, 10.1172/jci88880]
   Wu TZ, 2017, DIABETES CARE, V40, P702, DOI 10.2337/dc16-2391
   Yamagishi S, 2011, CURR DRUG TARGETS, V12, P2096, DOI 10.2174/138945011798829456
   Yoshida T, 2012, BIOORGAN MED CHEM, V20, P5033, DOI 10.1016/j.bmc.2012.06.033
   YOUN JH, 1987, J BIOL CHEM, V262, P11470
   Yu HY, 2012, J DIABETES, V4, P30, DOI 10.1111/j.1753-0407.2011.00170.x
   Zhan Y, 2012, MED SCI MONITOR, V18, pBR286, DOI 10.12659/MSM.883207
   Zhang CW, 2020, BIOMED PHARMACOTHER, V131, DOI 10.1016/j.biopha.2020.110795
NR 89
TC 0
Z9 0
U1 1
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD APR
PY 2025
VL 398
IS 4
BP 3697
EP 3715
DI 10.1007/s00210-024-03439-3
EA OCT 2024
PG 19
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 1DD9W
UT WOS:001326987700005
PM 39356321
OA hybrid
DA 2025-06-11
ER

PT J
AU Incel-Uysal, P
   Akdogan, N
   Alli, N
   Oktem, A
   Candar, T
   Topcuoglu, C
   Turhan, T
AF Incel-Uysal, Pinar
   Akdogan, Nesthan
   Alli, Nuran
   Oktem, Ayse
   Candar, Tuba
   Topcuoglu, Canan
   Turhan, Turan
TI Assessment of Metabolic Profile and Ischemia-modified Albumin Level in
   Patients with Alopecia Areata: A Case-Control Study
SO INDIAN JOURNAL OF DERMATOLOGY
LA English
DT Article
DE Alopecia areata; ischemia-modified albumin; metabolic parameters; small
   dense low-density lipoprotein; visfatin
ID OXIDATIVE STRESS; COMORBIDITY PROFILES; VISFATIN; INFLAMMATION;
   BIOMARKER; ONSET
AB Background: Alopecia areata (AA) is an autoimmune-mediated hair follicle disorder. In the literature, there is no study evaluating metabolic syndrome and levels of ischemia-modified albumin (IMA) which is proposed as an oxidative stress biomarker in patients with AA. Aims: The aim was to investigate the presence of metabolic syndrome and the levels of IMA, small dense low-density lipoprotein (sd-LDL), and visfatin levels in AA patients. Settings and Design: A hospital-based cross-sectional study was undertaken among AA patients and controls. Subjects and Methods: Thirty-five patients with AA and 35 sex-, age-, and body mass index-matched healthy controls were enrolled. Clinical and laboratory parameters of metabolic syndrome were examined in all participants. Furthermore, IMA, sd-LDL, and visfatin levels were assessed and analyzed with regard to disease pattern, severity and extent, severity of alopecia tool score, duration, and recurrence. Results: The median IMA and adjusted IMA levels were significantly increased compared with controls (P<0.05 and P=0.002, respectively). Patients with pull test positivity displayed higher levels of adjusted IMA levels (P<0.05). In AA group, there was a positive correlation between adjusted IMA and waist circumference (r=0.443, P=0.008), adjusted IMA and triglyceride levels (r=0.535, P=0.001), and adjusted IMA and sd-LDL levels (r=0.46, P<0.05). We observed no statistically significant difference in fasting blood glucose and lipid profile, sd-LDL, and visfatin levels of the patients and healthy controls. Conclusions: AA patients and controls have similar metabolic profile. Raised levels of adjusted IMA levels may be associated with antioxidant/oxidant imbalance and with risk of cardiovascular disease.
C1 [Incel-Uysal, Pinar; Akdogan, Nesthan; Alli, Nuran; Oktem, Ayse] Ankara Numune Training & Res Hosp, Dept Dermatol, Ankara, Turkey.
   [Topcuoglu, Canan; Turhan, Turan] Ankara Numune Training & Res Hosp, Dept Med Biochem, Ankara, Turkey.
   [Candar, Tuba] Ufuk Univ, Dept Med Biochem, Fac Med, Ankara, Turkey.
C3 Ankara Numune Training & Research Hospital; Ankara Numune Training &
   Research Hospital; Ufuk University
RP Incel-Uysal, P (corresponding author), Ankara Numune Training & Res Hosp, Dept Dermatol, Ankara, Turkey.
EM pinarincel@hotmail.com
RI Incel Uysal, Pınar/C-6148-2019; öktem, ayşe/AIC-3378-2022; turhan,
   turan/CAH-5850-2022
OI Akdogan, Neslihan/0000-0002-1137-5399; Incel uysal,
   Pinar/0000-0002-4540-6560
CR Ahn JH, 2011, NEUROL SCI, V32, P133, DOI 10.1007/s10072-010-0457-4
   Bakry OA, 2014, AM J CLIN DERMATOL, V15, P57, DOI 10.1007/s40257-013-0036-6
   Brunzell JD, 2003, AM J MED, V115, P24, DOI 10.1016/j.amjmed.2003.08.011
   Capkin E, 2015, JOINT BONE SPINE, V82, P68, DOI 10.1016/j.jbspin.2014.06.007
   Chu SY, 2011, J AM ACAD DERMATOL, V65, P949, DOI 10.1016/j.jaad.2010.08.032
   Davies Jonathan T, 2016, Lipid Insights, V9, P13
   Duarte MMMF, 2009, CLIN BIOCHEM, V42, P666, DOI 10.1016/j.clinbiochem.2009.01.010
   Eknoyan G, 2008, NEPHROL DIAL TRANSPL, V23, P47, DOI 10.1093/ndt/gfm517
   Fattah NSAA, 2011, J EUR ACAD DERMATOL, V25, P403, DOI 10.1111/j.1468-3083.2010.03799.x
   Gerdes S, 2012, EXP DERMATOL, V21, P43, DOI 10.1111/j.1600-0625.2011.01402.x
   Hakligör A, 2010, CLIN BIOCHEM, V43, P345, DOI 10.1016/j.clinbiochem.2009.09.006
   Hirano T, 2004, ARTERIOSCL THROM VAS, V24, P558, DOI 10.1161/01.ATV.0000117179.92263.08
   Huang KP, 2016, J AM ACAD DERMATOL, V75, P151, DOI 10.1016/j.jaad.2016.02.1234
   Ishak Rim S, 2013, J Investig Dermatol Symp Proc, V16, pS56, DOI 10.1038/jidsymp.2013.22
   Ismail SA, 2012, BRIT J DERMATOL, V167, P436, DOI 10.1111/j.1365-2133.2012.10980.x
   Ito T, 2014, EXP DERMATOL, V23, P787, DOI 10.1111/exd.12489
   Ivanova EA, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/1273042
   Jabbari A, 2016, EBIOMEDICINE, V7, P240, DOI 10.1016/j.ebiom.2016.03.036
   Kang JH, 2015, SCI REP-UK, V5, DOI 10.1038/srep11718
   Karadag AS, 2013, CUTAN OCUL TOXICOL, V32, P102, DOI 10.3109/15569527.2012.713418
   Kavak A, 2000, INT J DERMATOL, V39, P589, DOI 10.1046/j.1365-4362.2000.00921.x
   Koca R, 2005, MED SCI MONITOR, V11, pCR296
   Lee NR, 2014, ANN DERMATOL, V26, P722, DOI 10.5021/ad.2014.26.6.722
   Lim Chean Ping, 2018, J Investig Dermatol Symp Proc, V19, pS57, DOI 10.1016/j.jisp.2017.10.006
   Luk T, 2008, J LEUKOCYTE BIOL, V83, P804, DOI 10.1189/jlb.0807581
   Olsen EA, 2004, J AM ACAD DERMATOL, V51, P440, DOI 10.1016/j.jaad.2003.09.032
   Özdemir M, 2012, CLIN EXP DERMATOL, V37, P610, DOI 10.1111/j.1365-2230.2012.04384.x
   Ozgen M, 2011, CLIN RHEUMATOL, V30, P757, DOI 10.1007/s10067-010-1649-2
   Piva SJ, 2011, CLIN BIOCHEM, V44, P345, DOI 10.1016/j.clinbiochem.2010.12.001
   Strazzulla LC, 2018, J AM ACAD DERMATOL, V78, P1, DOI 10.1016/j.jaad.2017.04.1141
   Suga H, 2013, EUR J DERMATOL, V23, P629, DOI 10.1684/ejd.2013.2107
   Tilg H, 2006, NAT REV IMMUNOL, V6, P772, DOI 10.1038/nri1937
   Trüeb RM, 2018, CLIN REV ALLERG IMMU, V54, P68, DOI 10.1007/s12016-017-8620-9
   Wang EHC, 2018, ACTA DERM-VENEREOL, V98, P776, DOI 10.2340/00015555-2964
   Yenin JZ, 2015, CLIN EXP DERMATOL, V40, P617, DOI 10.1111/ced.12556
NR 35
TC 17
Z9 17
U1 0
U2 1
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0019-5154
EI 1998-3611
J9 INDIAN J DERMATOL
JI Indian J. Dermatol.
PD JAN-FEB
PY 2019
VL 64
IS 1
BP 12
EP 18
DI 10.4103/ijd.IJD_238_18
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA HH5MR
UT WOS:000455771700003
PM 30745629
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fortuño, A
   Bidegain, J
   San José, G
   Robador, PA
   Landecho, MF
   Beloqui, O
   Díez, J
   Zalba, G
AF Fortuno, Ana
   Bidegain, Julen
   San Jose, Gorka
   Robador, Pablo A.
   Landecho, Manuel F.
   Beloqui, Oscar
   Diez, Javier
   Zalba, Guillermo
TI Insulin resistance determines phagocytic nicotinamide adenine
   dinucleotide phosphate oxidase overactivation in metabolic syndrome
   patients
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE insulin resistance; metabolic syndrome; monocyte/macrophage;
   nicotinamide adenine dinucleotide phosphate oxidase; superoxide
ID DEPENDENT SUPEROXIDE-PRODUCTION; OXIDATIVE STRESS; NAD(P)H OXIDASE;
   HUMAN ATHEROSCLEROSIS; SUBUNIT P22(PHOX); NADPH OXIDASES; NOX FAMILY;
   HYPERTENSION; EXPRESSION; OBESITY
AB Objective Metabolic syndrome (MetS) is associated with insulin resistance and increases the cardiovascular risk. Oxidative stress constitutes a potential mechanism that links insulin resistance and cardiovascular disease. The aim of this study was to analyze the relationship of NADPH oxidase activation with insulin resistance, and the effect of this interaction on the cardiovascular risk in MetS patients.
   Methods NADPH oxidase-dependent superoxide production and expression was evaluated by luminescence and western blot, respectively, in peripheral blood mononuclear cells obtained from 125 patients with MetS. Insulin resistance was defined by the homeostasis model assessment index. Matrix metalloproteinase-9 was quantified by enzyme-linked immunosorbent assay in plasma samples. To ascertain the mechanisms involved in vivo, we performed in-vitro experiments in cultured macrophages.
   Results Fifty- six percent of patients with MetS showed insulin resistance. Plasma matrix metalloproteinase-9 levels were higher (P < 0.05) in insulin-resistant patients than in patients with insulin sensitivity. NADPH oxidase-dependent superoxide production was augmented (P < 0.05) in insulin-resistant patients with respect to insulin-sensitive patients. The interaction between insulin resistance and abnormally high NADPH oxidase-mediated superoxide production was associated with the highest matrix metalloproteinase- 9 values. Increased NADPH oxidase-dependent superoxide production was significantly associated with higher NADPH oxidase p22(phox) expression in insulin-resistant than in insulin-sensitive patients. Interestingly, insulin upregulated p22(phox) in peripheral blood mononuclear cells and in murine macrophages.
   Conclusion Insulin resistance is associated with phagocytic NADPH oxidase activation. This association results in the highest cardiovascular risk in MetS patients. J Hypertens 27:1420-1430 (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.
C1 [Fortuno, Ana; Bidegain, Julen; San Jose, Gorka; Robador, Pablo A.; Diez, Javier; Zalba, Guillermo] Univ Navarra, Ctr Appl Med Res, Div Cardiovasc Sci, Pamplona 31008, Spain.
   [Landecho, Manuel F.; Beloqui, Oscar] Univ Navarra, Dept Internal Med, Pamplona 31008, Spain.
   [Diez, Javier] Univ Navarra, Dept Cardiol & Cardiovasc Surg, Univ Clin, Pamplona 31008, Spain.
C3 University of Navarra; University of Navarra; University of Navarra
RP Zalba, G (corresponding author), Univ Navarra, Ctr Appl Med Res, Div Cardiovasc Sci, Av Pio 12 55, Pamplona 31008, Spain.
EM gzalba@unav.es
RI Landecho, Manuel/D-9227-2013; ZALBA, GUILLERMO/AAB-6231-2019; Diez
   Martinez, Domingo Francisco Javier/D-7014-2017; Fortuno,
   Ana/C-6921-2017; San Jose, Gorka/K-7501-2017
OI Diez Martinez, Domingo Francisco Javier/0000-0002-3414-6919; Landecho,
   Manuel F/0000-0003-3234-8805; Beloqui Ruiz, Oscar/0000-0001-9542-3687;
   ZALBA, GUILLERMO/0000-0003-4616-1523; Fortuno, Ana/0000-0002-0796-4879;
   San Jose, Gorka/0000-0001-5878-1741
FU Foundation for Applied Medical Research (FIMA); Instituto de Salud
   Carlos III, Ministry of Health [RD06/0014/0008]; European Union
   [LSHMCT-2006- 037093]; Foundation MMA; Department of Health of
   Government of Navarra [25/2005]; Ministry of Science and Education
   [SAF2004-07910]; Ministry of Science and Culture [SAF2007-62533]
FX This study was funded through the agreement between the Foundation for
   Applied Medical Research (FIMA) and 'UTE project CIMA', by the red
   Tematica de Investigacion Cooperativa en Enfermedades Cardiovasculares
   (RECAVA) from the Instituto de Salud Carlos III, Ministry of Health
   (grant RD06/0014/0008), by the European Union (InGenious HyperCare,
   grant LSHMCT-2006- 037093), by the Foundation MMA, by the Department of
   Health of Government of Navarra (grant 25/2005), by the Ministry of
   Science and Education (grant SAF2004-07910) and by the Ministry of
   Science and Culture (grant SAF2007-62533), Spain.
CR Avogaro A, 2003, J CLIN ENDOCR METAB, V88, P1753, DOI 10.1210/jc.2002-021025
   Azumi H, 1999, CIRCULATION, V100, P1494, DOI 10.1161/01.CIR.100.14.1494
   Bedard K, 2007, PHYSIOL REV, V87, P245, DOI 10.1152/physrev.00044.2005
   Blackburn P, 2003, DIABETES CARE, V26, P3303, DOI 10.2337/diacare.26.12.3303
   Ceolotto G, 2004, DIABETES, V53, P1344, DOI 10.2337/diabetes.53.5.1344
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Dandona P, 2001, J CLIN ENDOCR METAB, V86, P3257, DOI 10.1210/jc.86.7.3257
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   Delbosc S, 2005, ATHEROSCLEROSIS, V179, P43, DOI 10.1016/j.atherosclerosis.2004.10.018
   Esposito K, 2006, J ENDOCRINOL INVEST, V29, P791, DOI 10.1007/BF03347372
   Evans JL, 2005, ANTIOXID REDOX SIGN, V7, P1040, DOI 10.1089/ars.2005.7.1040
   Facchini FS, 2000, FREE RADICAL BIO MED, V29, P1302, DOI 10.1016/S0891-5849(00)00438-X
   Fortuño A, 2006, DIABETES, V55, P209, DOI 10.2337/diabetes.55.1.209
   Fortuño A, 2004, J HYPERTENS, V22, P2169, DOI 10.1097/00004872-200411000-00020
   Grundy SM, 2007, J CLIN ENDOCR METAB, V92, P399, DOI 10.1210/jc.2006-0513
   Grundy SM, 2006, J AM COLL CARDIOL, V47, P1093, DOI 10.1016/j.jacc.2005.11.046
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Guzik TJ, 2002, CIRCULATION, V105, P1656, DOI 10.1161/01.CIR.0000012748.58444.08
   Heumüller S, 2008, HYPERTENSION, V51, P211, DOI 10.1161/HYPERTENSIONAHA.107.100214
   Mahadev K, 2004, MOL CELL BIOL, V24, P1844, DOI 10.1128/MCB.24.5.1844-1854.2004
   Meerarani P, 2006, CURR MOL MED, V6, P501, DOI 10.2174/156652406778018680
   Moreno MU, 2003, FEBS LETT, V542, P27, DOI 10.1016/S0014-5793(03)00331-4
   Nigro J, 2006, ENDOCR REV, V27, P242, DOI 10.1210/er.2005-0007
   Pettit AI, 2002, J HYPERTENS, V20, P677, DOI 10.1097/00004872-200204000-00025
   Sonta T, 2004, FREE RADICAL BIO MED, V37, P115, DOI 10.1016/j.freeradbiomed.2004.04.001
   Sorescu D, 2002, CIRCULATION, V105, P1429, DOI 10.1161/01.CIR.0000012917.74432.66
   Trayhurn P, 2005, BIOCHEM SOC T, V33, P1078, DOI [10.1042/BST0331078, 10.1042/BST20051078]
   UCHIYAMA M, 1978, ANAL BIOCHEM, V86, P271, DOI 10.1016/0003-2697(78)90342-1
   Zalba G, 2005, ARTERIOSCL THROM VAS, V25, P1452, DOI 10.1161/01.ATV.0000168411.72483.08
   Zalba G, 2007, ARTERIOSCL THROM VAS, V27, P587, DOI 10.1161/01.ATV.0000256467.25384.c6
   Zhuang DM, 2004, AM J PHYSIOL-HEART C, V286, pH2103, DOI 10.1152/ajpheart.01118.2003
NR 31
TC 12
Z9 13
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD JUL
PY 2009
VL 27
IS 7
BP 1420
EP 1430
DI 10.1097/HJH.0b013e32832b1e8f
PG 11
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 467ZW
UT WOS:000267783800015
PM 19357530
DA 2025-06-11
ER

PT J
AU Vazquez-Prieto, MA
   Renna, NF
   Diez, ER
   Cacciamani, V
   Lembo, C
   Miatello, RM
AF Vazquez-Prieto, Marcela A.
   Renna, Nicolas F.
   Diez, Emiliano R.
   Cacciamani, Valeria
   Lembo, Carina
   Miatello, Roberto M.
TI Effect of Red Wine on Adipocytokine Expression and Vascular Alterations
   in Fructose-Fed Rats
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
DE adipocytokines; blood pressure; hypertension; metabolic syndrome;
   resistin; adiponectin; red wine
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; EXPERIMENTAL-MODEL; OXIDATIVE
   STRESS; ANGIOTENSIN-II; ADIPOSE-TISSUE; DEFICIENT MICE; CELL-FUNCTION;
   ADIPONECTIN; ALCOHOL
AB BACKGROUND
   Imbalance in adipocytokines secretion is related to the development of metabolic syndrome (MS). In addition, moderate consumption of red wine (RW) decreases the risk of cardiovascular disease. The aim of this study was to evaluate the effects of moderate consumption of RW or ethanol (E) on adiponectin and resistin expression, and vascular alterations in fructose-fed rats (FFRs) as an experimental model of MS.
   METHODS
   Thirty-day-old male Wistar rats were assigned to control (C), F (10% fructose in drinking water), F+E (4.5 ml/kg), and F+RW (35 ml/kg of Malbec RW containing 4.5 ml/kg E). E and RW were administered during the last 4 weeks of a 10-week period.
   RESULTS
   RW administration to F rats was able to significantly decrease insulin resistance, mesenteric adipose tissue weight, and systolic blood pressure (SBP) compared to F group. F+E only reduced the SBP (P<0.05 vs. F). F+RW also reduced aortic NAD(P)H-oxidase activity, NAD(P)H subunits Nox4 expression in mesenteric tissue, plasma thiobarbituric acid reactive substances (TBARS), and recovered plasma total antioxidant activity (TAA) compared to F and F+E groups (P<0.05). Adiponectin expression decreased, whereas resistin, vascular cell adhesion molecules-1 (VCAM-1), and nuclear factor-kB (NF-kB) expression and vascular remodeling in mesenteric arteries were higher in F than in C group (P<0.05). Only RW was able to partially reverse the aforementioned alterations.
   CONCLUSION
   In this study, Malbec RW, but not alcohol alone, improved the balance of adipocytokines and attenuated the oxidative stress and vascular inflammation in a model of MS, suggesting that nonalcohol components of RW are responsible for the beneficial effects.
C1 [Vazquez-Prieto, Marcela A.; Renna, Nicolas F.; Diez, Emiliano R.; Cacciamani, Valeria; Lembo, Carina; Miatello, Roberto M.] Natl Univ Cuyo, Sch Med, Dept Pathol, Mendoza, Argentina.
   [Vazquez-Prieto, Marcela A.; Renna, Nicolas F.; Diez, Emiliano R.; Lembo, Carina; Miatello, Roberto M.] Consejo Nacl Invest Cient & Tecn, Natl Res Council, Inst Expt Med & Biol Res IMBECU, Lab Cardiovasc Pathophysiol, Mendoza, Argentina.
C3 University Nacional Cuyo Mendoza; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET)
RP Miatello, RM (corresponding author), Natl Univ Cuyo, Sch Med, Dept Pathol, Mendoza, Argentina.
EM rmiatell@fcm.uncu.edu.ar
RI Prieto, Marcela/W-4291-2019; Diez, Emiliano/KIB-2439-2024
OI Diez, Emiliano/0000-0001-5163-3703
FU National Council of Research [PIP 5192]; National University of Cuyo
FX This work was supported by a Grant from National Council of Research
   (PIP 5192) and Program I+D from the National University of Cuyo. The
   authors thank Susana Gonzalez and Cristina Lama for their technical
   assistance.
CR Agouni A, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005557
   Al-Awwadi NA, 2004, J AGR FOOD CHEM, V52, P5593, DOI 10.1021/jf049295g
   Alzamendi A, 2009, ENDOCRINE, V35, P227, DOI 10.1007/s12020-008-9143-1
   Bantle JP, 2009, J NUTR, V139, pS1263, DOI 10.3945/jn.108.098020
   Bargalló MV, 2006, J NUTR BIOCHEM, V17, P139, DOI 10.1016/j.jnutbio.2005.06.005
   Cruzado MC, 2005, AM J HYPERTENS, V18, P81, DOI 10.1016/j.amjhyper.2004.09.001
   de Martin R, 2000, ARTERIOSCL THROM VAS, V20, pE83
   Fantuzzi G, 2007, ARTERIOSCL THROM VAS, V27, P996, DOI 10.1161/ATVBAHA.106.131755
   Fanzone M, 2010, J AGR FOOD CHEM, V58, P2388, DOI 10.1021/jf903690v
   Fischer-Posovszky P, 2010, AM J CLIN NUTR, V92, P5, DOI 10.3945/ajcn.2009.28435
   Fortuño A, 2005, EXP PHYSIOL, V90, P457, DOI 10.1113/expphysiol.2005.030098
   Guzik TJ, 2006, J PHYSIOL PHARMACOL, V57, P505
   Guzik TJ, 2006, ARTERIOSCL THROM VAS, V26, P333, DOI 10.1161/01.ATV.0000196651.64776.51
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Kawanami D, 2004, BIOCHEM BIOPH RES CO, V314, P415, DOI 10.1016/j.bbrc.2003.12.104
   Laville M, 2009, OBES REV, V10, P24, DOI 10.1111/j.1467-789X.2008.00562.x
   Liu K, 2010, BIOCHIMIE, V92, P789, DOI 10.1016/j.biochi.2010.02.024
   Matsuzawa Y, 2004, ARTERIOSCL THROM VAS, V24, P29, DOI 10.1161/01.ATV.0000099786.99623.EF
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Miatello R, 2005, AM J HYPERTENS, V18, P864, DOI 10.1016/j.amjhyper.2004.12.012
   Miatello R, 2002, AM J HYPERTENS, V15, P872, DOI 10.1016/S0895-7061(02)02983-7
   Miatello Roberto, 2004, Current Vascular Pharmacology, V2, P371, DOI 10.2174/1570161043385510
   Monteiro R, 2009, NUTRITION, V25, P699, DOI 10.1016/j.nut.2009.01.001
   Murase T, 2002, INT J OBESITY, V26, P1459, DOI 10.1038/sj.ijo.0802141
   Napoli R, 2005, METABOLISM, V54, P306, DOI 10.1016/j.metabol.2004.09.010
   Nyby MD, 2007, HYPERTENS RES, V30, P451, DOI 10.1291/hypres.30.451
   O'Keefe JH, 2007, J AM COLL CARDIOL, V50, P1009, DOI 10.1016/j.jacc.2007.04.089
   Okamoto Y, 2002, CIRCULATION, V106, P2767, DOI 10.1161/01.CIR.0000042707.50032.19
   Olholm J, 2010, INT J OBES LOND
   Re R, 1999, FREE RADICAL BIO MED, V26, P1231, DOI 10.1016/S0891-5849(98)00315-3
   RENAUD S, 1992, LANCET, V339, P1523, DOI 10.1016/0140-6736(92)91277-F
   Renna NF, 2009, CLIN EXP PHARMACOL P, V36, P162, DOI 10.1111/j.1440-1681.2008.05042.x
   Ru XC, 2008, ALCOHOL ALCOHOLISM, V43, P537, DOI 10.1093/alcalc/agn042
   Sarr M, 2006, CARDIOVASC RES, V71, P794, DOI 10.1016/j.cardiores.2006.05.022
   Stanhope KL, 2009, J NUTR, V139, pS1236, DOI 10.3945/jn.109.106641
   Terra X, 2009, J NUTR BIOCHEM, V20, P210, DOI 10.1016/j.jnutbio.2008.02.005
   VOISIN EM, 1990, REGUL TOXICOL PHARM, V12, P107, DOI 10.1016/S0273-2300(05)80052-2
   Wollin SD, 2001, J NUTR, V131, P1401, DOI 10.1093/jn/131.5.1401
   Wollny T, 1999, BRIT J PHARMACOL, V127, P747, DOI 10.1038/sj.bjp.0702586
   Yamauchi T, 2003, J BIOL CHEM, V278, P2461, DOI 10.1074/jbc.M209033200
   Zheng GD, 2004, IN VIVO, V18, P55
NR 41
TC 20
Z9 21
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0895-7061
EI 1941-7225
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD FEB
PY 2011
VL 24
IS 2
BP 234
EP 240
DI 10.1038/ajh.2010.214
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 709PC
UT WOS:000286451600017
PM 20885371
OA Bronze
DA 2025-06-11
ER

PT J
AU Vazquez-Prieto, MA
   Renna, NF
   Lembo, C
   Diez, ER
   Miatello, RM
AF Alejandra Vazquez-Prieto, Marcela
   Federico Renna, Nicolas
   Lembo, Carina
   Raul Diez, Emiliano
   Miguel Miatello, Roberto
TI Dealcoholized red wine reverse vascular remodeling in an experimental
   model of metabolic syndrome: role of NAD(P)H oxidase and eNOS activity
SO FOOD & FUNCTION
LA English
DT Article
ID PREVENTS ENDOTHELIAL DYSFUNCTION; SMOOTH-MUSCLE-CELLS; FRUCTOSE-FED
   RATS; NADPH OXIDASE; INSULIN-RESISTANCE; ANGIOTENSIN-II; DIETARY
   POLYPHENOLS; FRENCH PARADOX; NITRIC-OXIDE; HYPERTENSION
AB The present study examines the effect of chronic administration of dealcoholized red wine Malbec (DRW) on vascular remodeling and NAD(P)H oxidase and endothelial nitric oxide synthase activity (eNOS) in an experimental model of metabolic syndrome induced by fructose administration. Thirty-day old male Wistar rats were fed a normal rat diet (control) or the same diet plus 10% fructose in drinking water (FFR). During the last 4 weeks of a 10-week period of the corresponding diet, a subgroup of control and FFR (a = 8 each) received DRW in their drinking water. Systolic blood pressure (SBP), a homeostasis model assessment of insulin resistance (HOMA-IR), aortic NAD(P)H oxidase and eNOS activity in the heart and vascular tissue were evaluated. Vascular remodeling was evaluated in the left carotid artery (CA) and interlobar, arcuate and interlobular renal arteries (RA) through lumen to media (L/M) ratio determination. At the end of the study FFR increased the SBP (p < 0.001), HOMA-IR (p < 0.001), and aortic NAD(P)H oxidase activity (p < 0,05) but reduced cardiac and vascular eNOS activity (p < 0.01), L/M ratio in CA (p < 0.001) and RA (p < 0.01) compared with the C group. DRW reduced SBP (p < 0.05), aortic NAD(P)H oxidase (p < 0.05), and recovered eNOS activity (p < 0.001) and L/M in CA (p < 0.001) and RA (p < 0.001) compared with FFR. This study provides new data about the beneficial effect of DRW on oxidative stress and vascular remodeling in the experimental model of metabolic syndrome. Data suggest the participation of mechanisms involving oxidative stress in FFR alterations and the usefulness of natural antioxidant substances present in red wine in the reversion of these changes.
C1 [Alejandra Vazquez-Prieto, Marcela; Federico Renna, Nicolas; Lembo, Carina; Raul Diez, Emiliano; Miguel Miatello, Roberto] Univ Nacl Cuyo, Sch Med, Dept Pathol, RA-5500 Mendoza, Argentina.
   [Alejandra Vazquez-Prieto, Marcela; Federico Renna, Nicolas; Lembo, Carina; Raul Diez, Emiliano; Miguel Miatello, Roberto] Natl Council Res CONICET, Inst Expt Med & Biol Cuyo IMBECU, Mendoza, Argentina.
C3 University Nacional Cuyo Mendoza; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Instituto de Medicina y BiologIa
   Experimental de Cuyo (IMBECU)
RP Vazquez-Prieto, MA (corresponding author), Natl Council Res CONICET, Inst Expt Med & Biol Cuyo IMBECU, Mendoza, Argentina.
EM rmiatell@fcm.uncu.edu.ar
RI Diez, Emiliano/KIB-2439-2024; Prieto, Marcela/W-4291-2019
OI Diez, Emiliano/0000-0001-5163-3703
FU Universidad Nacional de Cuyo [06/P01]; CONICET [PIP-5192]
FX We thank Susana Gonzalez and Cristina Lama for their technical
   assistance. This work was supported by grants from Program 06/P01 SECTyP
   Universidad Nacional de Cuyo, and PIP-5192 CONICET.
CR Vazquez-Prieto MA, 2010, J AGR FOOD CHEM, V58, P6630, DOI 10.1021/jf1006819
   Beckman JS, 1996, AM J PHYSIOL-CELL PH, V271, pC1424
   Belleville J, 2002, NUTRITION, V18, P173, DOI 10.1016/S0899-9007(01)00721-3
   Chen X, 2001, HYPERTENSION, V38, P606, DOI 10.1161/hy09t1.094005
   Cruzado MC, 2005, AM J HYPERTENS, V18, P81, DOI 10.1016/j.amjhyper.2004.09.001
   Fantinelli JC, 2005, LIFE SCI, V76, P2721, DOI 10.1016/j.lfs.2004.10.044
   Fanzone M, 2010, J AGR FOOD CHEM, V58, P2388, DOI 10.1021/jf903690v
   Fortuño A, 2005, EXP PHYSIOL, V90, P457, DOI 10.1113/expphysiol.2005.030098
   Fraga CG, 2007, IUBMB LIFE, V59, P308, DOI 10.1080/15216540701230529
   HWANG IS, 1987, HYPERTENSION, V10, P512, DOI 10.1161/01.HYP.10.5.512
   Iijima K, 2000, CIRCULATION, V101, P805, DOI 10.1161/01.CIR.101.7.805
   Kojda G, 1999, CARDIOVASC RES, V43, P562, DOI 10.1016/S0008-6363(99)00169-8
   Leighton F, 1999, DRUG EXP CLIN RES, V25, P133
   Loke WM, 2010, ARTERIOSCL THROM VAS, V30, P749, DOI 10.1161/ATVBAHA.109.199687
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Miatello R, 2005, AM J HYPERTENS, V18, P864, DOI 10.1016/j.amjhyper.2004.12.012
   Miatello R, 2002, AM J HYPERTENS, V15, P872, DOI 10.1016/S0895-7061(02)02983-7
   Miatello R, 2001, AM J HYPERTENS, V14, P1135, DOI 10.1016/S0895-7061(01)02206-3
   Mosca SM, 2002, J CARDIOVASC PHARM, V40, P429, DOI 10.1097/00005344-200209000-00012
   Perez-Vizcaino F, 2006, FREE RADICAL RES, V40, P1054, DOI 10.1080/10715760600823128
   RENAUD S, 1992, LANCET, V339, P1523, DOI 10.1016/0140-6736(92)91277-F
   Renna NF, 2009, CLIN EXP PHARMACOL P, V36, P162, DOI 10.1111/j.1440-1681.2008.05042.x
   Sánchez M, 2006, J HYPERTENS, V24, P75, DOI 10.1097/01.hjh.0000198029.22472.d9
   Sarr M, 2006, CARDIOVASC RES, V71, P794, DOI 10.1016/j.cardiores.2006.05.022
   Steffen Y, 2008, ARCH BIOCHEM BIOPHYS, V469, P209, DOI 10.1016/j.abb.2007.10.012
   Steffen Y, 2007, BIOCHEM BIOPH RES CO, V359, P828, DOI 10.1016/j.bbrc.2007.05.200
   Stoclet JC, 2004, EUR J PHARMACOL, V500, P299, DOI 10.1016/j.ejphar.2004.07.034
   Tooke JE, 2000, J INTERN MED, V247, P425, DOI 10.1046/j.1365-2796.2000.00671.x
   Touyz RM, 2000, PHARMACOL REV, V52, P639
   Wang X, 2007, EUR J PHARMACOL, V555, P48, DOI 10.1016/j.ejphar.2006.10.017
NR 30
TC 8
Z9 9
U1 0
U2 5
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD OCT
PY 2010
VL 1
IS 1
BP 124
EP 129
DI 10.1039/c0fo00077a
PG 6
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA 758DG
UT WOS:000290140200010
PM 21776463
DA 2025-06-11
ER

PT J
AU Tápias, FS
   Otani, VHO
   Vasques, DAC
   Otani, TZS
   Uchida, RR
AF Tapias, Felipe Saia
   Oyamada Otani, Victor Henrique
   Correa Vasques, Daniel Augusto
   Santos Otani, Thais Zelia
   Uchida, Ricardo Riyoiti
TI Costs associated with depression and obesity among cardiovascular
   patients: medical expenditure panel survey analysis
SO BMC HEALTH SERVICES RESEARCH
LA English
DT Article
DE Depression; Cost; Cardiovascular conditions; Obesity
ID HEALTH-CARE COSTS; MAJOR DEPRESSION; ECONOMIC BURDEN; UNITED-STATES;
   PREVALENCE; DISEASE; OVERWEIGHT; OUTCOMES; PARADOX; ADULTS
AB Background There is a lack of information on the cost of depression associated with metabolic syndrome and cardiovascular diseases in the literature. Methods We evaluated the synergistic effects of depression and obesity on total expenditures for cardiovascular conditions using data from the Medical Expenditure Panel Survey (MEPS) database. We analyzed MEPS data from 1996 to 2017 comprising adult cardiovascular subjects. We categorized individuals following a combination of International Classification of Diseases ICD-9-CM and ICD-10 codes, and depression symptoms as evaluated using the Patient Health Questionnaire-2 (PHQ-2) depression screening tool. Our sample comprised cardiovascular patients aged 18 years and older, with a body mass index (BMI) between 18.5 and 60. Our study comprised unweighted sample of 96,697 (weighted sample of 938,835,031) adults, a US-nationwide representative sample of cardiovascular disease patients. The four response categories were: no depression; unrecognized depression; asymptomatic depression; and symptomatic depression. Our evaluated outcomes were total annual healthcare expenditures, including dental, emergency room, hospital outpatient, hospital inpatient, office-based, prescription, and home health care expenses. Results Asymptomatic and symptomatic depression was more frequent among obese individuals than in individuals with a normal BMI (p < 0.001). Total expenditure was highest among symptomatic depression individuals (17,536) and obese (9871) with cardiovascular disease. All the expenditure outcomes were significantly higher among symptomatic depression individuals than those without depression (p < 0.001), except for dental costs. All healthcare expenditures associated with obesity were higher compared to individuals with normal BMI with p < 0.001, except for emergency and home healthcare costs. Most importantly, among obese individuals, all healthcare expenditures were significantly higher (p < 0.001) in those with symptomatic depression than those without depression, except for dental costs, where the difference was not significant (0.899). Therefore, obesity and depression entail increased expenses in patients with cardiovascular disease. Conclusions We found incremental expenditures among unrecognized, asymptomatic, and symptomatic depressed individuals with obesity compared to non-depressed, non-obese subjects. However, these are preliminary results that should be further validated using different methodologies.
C1 [Tapias, Felipe Saia; Oyamada Otani, Victor Henrique; Correa Vasques, Daniel Augusto; Santos Otani, Thais Zelia; Uchida, Ricardo Riyoiti] Univ Med Sci Santa Casa Sao Paulo, Dr Cesario Motta Jr St 61, BR-01221020 Sao Paulo, SP, Brazil.
RP Tápias, FS (corresponding author), Univ Med Sci Santa Casa Sao Paulo, Dr Cesario Motta Jr St 61, BR-01221020 Sao Paulo, SP, Brazil.
EM felipetapias89@gmail.com
OI Otani, Victor/0000-0001-6337-6388
FU CAPES Brazil Coordination for the Improvement of Higher Education
   Personnel
FX The first author was granted a masters scholarship from CAPES Brazil
   Coordination for the Improvement of Higher Education Personnel over the
   course of this study. The funding body had no role in the design of the
   study, collection, analysis, and interpretation of data or the writing
   of this manuscript.
CR Alwhaibi M, 2020, DEPRESS ANXIETY, V37, P1146, DOI 10.1002/da.23063
   Andersen I, 2011, SCAND J PUBLIC HEALT, V39, P857, DOI 10.1177/1403494811424611
   Bautista LE, 2012, AM J HYPERTENS, V25, P505, DOI 10.1038/ajh.2011.256
   Béland SG, 2011, VALUE HEALTH, V14, P492, DOI 10.1016/j.jval.2010.11.015
   BENJAMINI Y, 1995, J R STAT SOC B, V57, P289, DOI 10.1111/j.2517-6161.1995.tb02031.x
   Blaine B, 2008, J HEALTH PSYCHOL, V13, P1190, DOI 10.1177/1359105308095977
   Boutelle KN, 2010, HEALTH PSYCHOL, V29, P293, DOI 10.1037/a0018645
   Brüne M, 2021, DIABETES CARE, V44, P407, DOI 10.2337/dc19-2487
   Chen Y, 2008, RES SOC ADMIN PHARM, V4, P244, DOI 10.1016/j.sapharm.2007.06.019
   Chowdhury SR., 2020, METHODOLOGY REPORT 3, V1996, P2007
   Compton WM, 2006, AM J PSYCHIAT, V163, P2141, DOI 10.1176/appi.ajp.163.12.2141
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   Decruyenaere A, 2020, CRIT CARE, V24, DOI 10.1186/s13054-020-03199-5
   Diercks DB, 2006, AM HEART J, V152, P140, DOI 10.1016/j.ahj.2005.09.024
   Egede LE, 2016, J GEN INTERN MED, V31, P615, DOI 10.1007/s11606-016-3650-1
   Elderon L, 2013, PROG CARDIOVASC DIS, V55, P511, DOI 10.1016/j.pcad.2013.03.010
   Fergusson DM, 2014, AUST NZ J PSYCHIAT, V48, P735, DOI 10.1177/0004867414525840
   Fournier JC, 2015, BRIT J PSYCHIAT, V206, P332, DOI 10.1192/bjp.bp.113.133694
   Gazmararian JA, 2015, J OBES, V2015, DOI 10.1155/2015/298698
   Gold SM, 2020, NAT REV DIS PRIMERS, V6, DOI 10.1038/s41572-020-0200-2
   Greenberg PE, 2015, J CLIN PSYCHIAT, V76, P155, DOI 10.4088/JCP.14m09298
   Hansen L, 2017, J CLIN ENDOCR METAB, V102, P1934, DOI 10.1210/jc.2016-3346
   James SL, 2018, LANCET, V392, P1789, DOI [10.1016/s0140-6736(18)32335-3, 10.1016/S0140-6736(18)32335-3]
   Jarlenski MP, 2013, AM J PREV MED, V44, P453, DOI 10.1016/j.amepre.2013.01.021
   Jha MK, 2019, J AM COLL CARDIOL, V73, P1827, DOI 10.1016/j.jacc.2019.01.041
   König H, 2020, EPIDEMIOL PSYCH SCI, V29, DOI 10.1017/S2045796019000180
   Konstantakopoulos G, 2019, Psychiatriki, V30, P281, DOI 10.22365/jpsych.2019.304.281
   Korn EL, 2011, ANAL HLTH SURVEYS, V323, P160
   Kroenke K, 2003, MED CARE, V41, P1284, DOI 10.1097/01.MLR.0000093487.78664.3C
   Kuhn M., 2013, Springer, V1st, DOI DOI 10.1007/978-1-4614-6849-3
   Lavie CJ, 2015, NAT REV ENDOCRINOL, V11, P55, DOI 10.1038/nrendo.2014.165
   Leal J, 2006, EUR HEART J, V27, P1610, DOI 10.1093/eurheartj/ehi733
   Lee JS, 2010, PUBLIC HEALTH REP, V125, P596, DOI 10.1177/003335491012500415
   Lee PH, 2014, SCI REP-UK, V4, DOI 10.1038/srep06085
   Liyanage Harshana, 2012, Inform Prim Care, V20, P221
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Mahanta TG, 2017, CLIN EPIDEMIOL GLOB, V5, P52, DOI 10.1016/j.cegh.2016.12.004
   McGrady A, 2009, J CARDIOPULM REHABIL, V29, P358, DOI 10.1097/HCR.0b013e3181be7a8f
   MEPS, 2015, **DATA OBJECT**
   Montesi L, 2016, DIABET METAB SYND OB, V9, P37, DOI 10.2147/DMSO.S89836
   Musich Shirley, 2016, Gerontol Geriatr Med, V2, p2333721415622004, DOI 10.1177/2333721415622004
   NIH  U.S. National Institute of Mental Health, 2019, MAJ DEPR
   OECD  Organisation for Economic Co-operation and Development, 2019, HEAV BURD OB EC PREV
   OECD  Organisation for Economic Co-operation and Development, 2020, INFL CPI
   Oga EA, 2016, J OBES, V2016, DOI 10.1155/2016/9040248
   Park JH, 2017, J STROKE, V19, P213, DOI 10.5853/jos.2016.01347
   Patten SB, 2015, CAN J PSYCHIAT, V60, P31, DOI 10.1177/070674371506000107
   Pereira-Miranda E, 2017, J AM COLL NUTR, V36, P223, DOI 10.1080/07315724.2016.1261053
   Piché ME, 2020, CIRC RES, V126, P1477, DOI 10.1161/CIRCRESAHA.120.316101
   Preston SH, 2014, EPIDEMIOLOGY, V25, P454, DOI 10.1097/EDE.0000000000000075
   R Core Team, 2015, R: a language and environment for statistical computing
   Rudisill C, 2016, CLIN OBES, V6, P225, DOI 10.1111/cob.12144
   Rutledge T, 2009, J AM COLL CARDIOL, V53, P176, DOI 10.1016/j.jacc.2008.09.032
   RUTTENVANMOLKEN MPMH, 1994, HEALTH ECON, V3, P333, DOI 10.1002/hec.4730030507
   Sharifi N, 2013, HEALTH PROMOT PERSPE, V3, P11, DOI 10.5681/hpp.2013.002
   Simon GE, 2011, J GEN INTERN MED, V26, P1284, DOI 10.1007/s11606-011-1774-x
   Sullivan M, 2002, ARCH INTERN MED, V162, P1860, DOI 10.1001/archinte.162.16.1860
   Tanner JA, 2020, CAN J PSYCHIAT, V65, P338, DOI 10.1177/0706743719895342
   Tran Bach Xuan, 2013, Cost Eff Resour Alloc, V11, P3, DOI 10.1186/1478-7547-11-3
   Tsai AG, 2011, OBES REV, V12, P50, DOI 10.1111/j.1467-789X.2009.00708.x
   Uher R, 2014, DEPRESS ANXIETY, V31, P459, DOI 10.1002/da.22217
   Unutzer J, 1997, JAMA, V277, P1618, DOI 10.1001/jama.277.20.1618
   von Elm E, 2007, PREV MED, V45, P247, DOI 10.1016/j.ypmed.2007.08.012
   Zhdanava M, 2020, J MANAG CARE SPEC PH, V26, P996, DOI 10.18553/jmcp.2020.20017
   Zuelke AE, 2018, J AFFECT DISORDERS, V235, P399, DOI 10.1016/j.jad.2018.04.073
NR 65
TC 6
Z9 8
U1 1
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6963
J9 BMC HEALTH SERV RES
JI BMC Health Serv. Res.
PD MAY 6
PY 2021
VL 21
IS 1
AR 433
DI 10.1186/s12913-021-06428-x
PG 14
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA SK4ZK
UT WOS:000656225300003
PM 33957919
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fernández-Abascal, B
   Suárez-Pinilla, P
   Cobo-Corrales, C
   Crespo-Facorro, B
   Suárez-Pinilla, M
AF Fernandez-Abascal, Blanca
   Suarez-Pinilla, Paula
   Cobo-Corrales, Carlos
   Crespo-Facorro, Benedicto
   Suarez-Pinilla, Marta
TI In- and outpatient lifestyle interventions on diet and exercise and
   their effect on physical and psychological health: a systematic review
   and meta-analysis of randomised controlled trials in patients with
   schizophrenia spectrum disorders and first episode of psychosis
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE non-affective psychosis; schizophrenia; non-pharmacological
   interventions; physical activity; exercise; psychoeducation; health
   promotion; cardiometabolic risk; quality of life; meta-analysis
ID INDUCED WEIGHT-GAIN; QUALITY-OF-LIFE; SINGLE-BLIND; YOGA THERAPY;
   METABOLIC ABNORMALITIES; MANAGEMENT PROGRAM; AEROBIC EXERCISE; TAI-CHI;
   NEUROCOGNITION; INDIVIDUALS
AB Patients with non-affective psychosis often lead unhealthy lifestyles. We performed a systematic review and meta-analysis on non-pharmacological RCTs for improvement of diet and physical activity in non-affective psychosis patients, including first-episode psychosis. A variety of outcomes was analysed, including metabolic, psychopathology, cognitive, functional and quality of life outcomes. Fifty-nine studies were included. An improvement in anthropometric measurements (BMI, weight, waist circumference) was observed postintervention, persisting after follow-up. Post-intervention benefit was found also for psychotic symptoms severity (also persisting after follow-up), many cognitive domains and physical and global functioning and quality of life. Conversely, no effect was observed in relation to most blood metabolites, blood pressure and nonpsychotic psychopathology and spontaneous physical activity. Improvement was generally larger for interventions including exercise, especially moderate/vigorous aerobic exercise, but follow-up maintenance was greater for psychotherapy interventions. Sensitivity analyses limited to chronic stages of psychosis and low risk of bias studies produced comparable results. Further studies are needed to design optimized interventions in this vulnerable population.
C1 [Fernandez-Abascal, Blanca; Suarez-Pinilla, Paula] Univ Hosp Marques Valdecilla, Dept Psychiat, IDIVAL, Santander 39011, Spain.
   [Suarez-Pinilla, Marta] UCL, Inst Neurol, Dept Neurodegenerat Dis, London WC1N 3AX, England.
   [Cobo-Corrales, Carlos] Univ Cantabria, Sch Educ, Santander 39005, Spain.
   [Crespo-Facorro, Benedicto] Univ Hosp Virgen del Rocio IBiS, Sch Med, Dept Psychiat, Seville 41013, Spain.
   [Suarez-Pinilla, Paula; Crespo-Facorro, Benedicto] Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid 28029, Spain.
C3 Hospital Universitario Marques de Valdecilla (HUMV); University of
   London; University College London; Universidad de Cantabria; Consejo
   Superior de Investigaciones Cientificas (CSIC); University of Sevilla;
   CSIC-JA-USE - Instituto de Biomedicina de Sevilla (IBIS); Virgen del
   Rocio University Hospital; CIBER - Centro de Investigacion Biomedica en
   Red; CIBERSAM; Instituto de Salud Carlos III
RP Fernández-Abascal, B; Suárez-Pinilla, P (corresponding author), Univ Hosp Marques Valdecilla, Dept Psychiat, IDIVAL, Santander 39011, Spain.; Suárez-Pinilla, M (corresponding author), UCL, Inst Neurol, Dept Neurodegenerat Dis, London WC1N 3AX, England.; Suárez-Pinilla, P (corresponding author), Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid 28029, Spain.; Fernández-Abascal, B (corresponding author), Univ Hosp Marques Valdecilla, Dept Psychiat, Avda Valdecilla S-N, Santander 39008, Spain.
EM blancafap@hotmail.com; p.suarez.pinilla@gmail.com
RI Crespo-Facorro, BENEDICTO/AAY-2238-2021; Suárez Pinilla,
   Marta/JHU-6581-2023
OI Suarez-Pinilla, Marta/0000-0002-6437-3741; Crespo-Facorro,
   Benedicto/0000-0003-0033-7132
CR Abdel-Baki A, 2013, SCHIZOPHR RES, V149, P112, DOI 10.1016/j.schres.2013.06.040
   Acil AA, 2008, J PSYCHIATR MENT HLT, V15, P808, DOI 10.1111/j.1365-2850.2008.01317.x
   Alberti KGMM, 2007, DIABETIC MED, V24, P451, DOI 10.1111/j.1464-5491.2007.02157.x
   Allison DB, 2001, J CLIN PSYCHIAT, V62, P22
   Alvarez-Jiménez M, 2006, J CLIN PSYCHIAT, V67, P1253, DOI 10.4088/JCP.v67n0812
   Alvarez-Jiménez M, 2010, SCHIZOPHR RES, V116, P16, DOI 10.1016/j.schres.2009.10.012
   Andersen R, 2013, EUR PSYCHIAT, V28, P332, DOI 10.1016/j.eurpsy.2012.06.003
   Silva BAE, 2015, REV BRAS PSIQUIATR, V37, P271, DOI 10.1590/1516-4446-2014-1595
   Angevaren M., 2008, COCHRANE DB SYST REV
   [Anonymous], 2008, COCHRANE HDB SYSTEMA, DOI DOI 10.1002/9780470712184.FMATTER
   Armstrong HF, 2016, SCHIZOPHR RES, V173, P116, DOI 10.1016/j.schres.2016.03.009
   Ashdown-Franks G, 2020, SPORTS MED, V50, P151, DOI 10.1007/s40279-019-01187-6
   Attux C, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-60
   Battaglia G, 2013, NEUROPSYCH DIS TREAT, V9, P595, DOI 10.2147/NDT.S44066
   Bechdolf A, 2004, ACTA PSYCHIAT SCAND, V110, P21, DOI 10.1111/j.1600-0447.2004.00300.x
   Beebe Lora Humphrey, 2005, Issues Ment Health Nurs, V26, P661
   Beebe LH, 2013, ISSUES MENT HEALTH N, V34, P214, DOI 10.3109/01612840.2012.746411
   Beebe LH, 2011, COMMUNITY MENT HLT J, V47, P628, DOI 10.1007/s10597-010-9363-8
   Bhatia T, 2017, ACTA NEUROPSYCHIATR, V29, P102, DOI 10.1017/neu.2016.42
   Bobes Julio, 2007, Dialogues Clin Neurosci, V9, P215
   Bonfioli E, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-78
   Brar JS, 2005, J CLIN PSYCHIAT, V66, P205, DOI 10.4088/JCP.v66n0208
   Brown C, 2014, SCHIZOPHR RES, V159, P421, DOI 10.1016/j.schres.2014.09.018
   Browne S, 1996, ACTA PSYCHIAT SCAND, V94, P118, DOI 10.1111/j.1600-0447.1996.tb09835.x
   Caemmerer J, 2012, SCHIZOPHR RES, V140, P159, DOI 10.1016/j.schres.2012.03.017
   Caponnetto P, 2019, MENT ILLN, V11, P22, DOI 10.4081/mi.2019.8003
   Cheng SL, 2017, J NURS RES, V25, P429, DOI 10.1097/JNR.0000000000000200
   COCHRAN WG, 1954, BIOMETRICS, V10, P101, DOI 10.2307/3001666
   Cohen J., 1988, STAT POWER ANAL BEHA, DOI [10.4324/9780203771587, DOI 10.4324/9780203771587]
   Cooper SJ, 2016, J PSYCHOPHARMACOL, V30, P717, DOI 10.1177/0269881116645254
   Cordes J, 2014, WORLD J BIOL PSYCHIA, V15, P229, DOI 10.3109/15622975.2011.592546
   Correll CU, 2006, J CLIN PSYCHIAT, V67, P575, DOI 10.4088/JCP.v67n0408
   Cumpston M, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.ED000142
   Curcic D, 2017, PSYCHIAT DANUB, V29, P459, DOI 10.24869/psyd.2017.459
   Dauwan M, 2016, SCHIZOPHRENIA BULL, V42, P588, DOI 10.1093/schbul/sbv164
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   Deci EL, 2000, PSYCHOL INQ, V11, P227, DOI 10.1207/S15327965PLI1104_01
   DerSimonian R, 2015, CONTEMP CLIN TRIALS, V45, P139, DOI 10.1016/j.cct.2015.09.002
   Faulkner G, 2003, ACTA PSYCHIAT SCAND, V108, P324, DOI 10.1034/j.1600-0447.2003.00218.x
   Fett AKJ, 2011, NEUROSCI BIOBEHAV R, V35, P573, DOI 10.1016/j.neubiorev.2010.07.001
   Firth J, 2018, EARLY INTERV PSYCHIA, V12, P307, DOI 10.1111/eip.12329
   Fisher E, 2020, PSYCHIAT RES, V286, DOI 10.1016/j.psychres.2020.112840
   Forsberg KA, 2008, NORD J PSYCHIAT, V62, P486, DOI 10.1080/08039480801985179
   Gage SH, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.244
   Gagliardi AR, 2016, IMPLEMENT SCI, V11, DOI 10.1186/s13012-016-0399-1
   Gaitero Calleja AM, 2007, PSICOTHEMA, V19, P640
   Gates J., 2015, LANCET PSYCHIAT
   Gurusamy J, 2018, ASIAN J PSYCHIATR, V36, P73, DOI 10.1016/j.ajp.2018.06.018
   Henderson DC, 2015, LANCET PSYCHIAT, V2, P452, DOI 10.1016/S2215-0366(15)00115-7
   Higgins JP, 2011, BMJ, V343, pd5928, DOI [DOI 10.1136/BMJ.D5928, 10.1136/bmj.d5928.22008217]
   Higgins JPT, 2004, STAT MED, V23, P1663, DOI 10.1002/sim.1752
   Higgins JPT, 2003, BMJ-BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557
   Ho RTH, 2016, SCHIZOPHR RES, V171, P42, DOI 10.1016/j.schres.2016.01.038
   Holt RIG, 2019, BRIT J PSYCHIAT, V214, P63, DOI 10.1192/bjp.2018.167
   Holt RI, 2018, HEALTH TECHNOL ASSES, V22, P1, DOI 10.3310/hta22650
   Hsu CC, 2016, INT J PSYCHOPHYSIOL, V109, P132, DOI 10.1016/j.ijpsycho.2016.08.011
   Iglesias-García C, 2010, J PSYCHIATR MENT HLT, V17, P849, DOI 10.1111/j.1365-2850.2010.01590.x
   Ikai S, 2017, J PSYCHIATR RES, V94, P194, DOI 10.1016/j.jpsychires.2017.07.015
   Ikai S, 2014, J ALTERN COMPLEM MED, V20, P823, DOI 10.1089/acm.2014.0205
   Ikai S, 2013, J PSYCHIATR RES, V47, P1744, DOI 10.1016/j.jpsychires.2013.07.017
   Isuru A., 2015, S ASIAN J PSYCHIAT, V3, P1
   Jayaram N, 2013, INDIAN J PSYCHIAT, V55, pS409, DOI 10.4103/0019-5545.116318
   Jean-Baptiste M, 2007, SCHIZOPHR RES, V96, P198, DOI 10.1016/j.schres.2007.05.022
   Kaltsatou A, 2015, CLIN REHABIL, V29, P882, DOI 10.1177/0269215514564085
   Kang RY, 2016, PSYCHOPATHOLOGY, V49, P345, DOI 10.1159/000448195
   Kim HJ, 2014, PSYCHIAT RES, V220, P792, DOI 10.1016/j.psychres.2014.09.020
   Kimhy D, 2015, SCHIZOPHRENIA BULL, V41, P859, DOI 10.1093/schbul/sbv022
   Kimhy D, 2014, PSYCHIAT RES, V220, P784, DOI 10.1016/j.psychres.2014.08.052
   Kurtz Matthew M, 2006, Expert Rev Neurother, V6, P47, DOI 10.1586/14737175.6.1.47
   Kwon JS, 2006, J CLIN PSYCHIAT, V67, P547, DOI 10.4088/JCP.v67n0405
   Laws Keith R, 2018, BMC Psychol, V6, P32, DOI 10.1186/s40359-018-0243-2
   Lepage M, 2014, CAN J PSYCHIAT, V59, P5, DOI 10.1177/070674371405900103
   Leucht S, 2020, AM J PSYCHIAT, V177, P342, DOI 10.1176/appi.ajp.2019.19010034
   Leucht S, 2013, LANCET, V382, P951, DOI 10.1016/S0140-6736(13)60733-3
   Leutwyler H, 2014, BIOL RES NURS, V16, P23, DOI 10.1177/1099800413500845
   Li J, 2018, COMPLEMENT THER CLIN, V32, P17, DOI 10.1016/j.ctcp.2018.04.003
   Lin JX, 2015, NPJ SCHIZOPHR, V1, DOI 10.1038/npjschz.2015.47
   Littrell KH, 2003, J NURS SCHOLARSHIP, V35, P237, DOI 10.1111/j.1547-5069.2003.00237.x
   Loh Siew Yim, 2015, Glob J Health Sci, V8, P238, DOI 10.5539/gjhs.v8n1p238
   Lovell K, 2014, J CLIN PSYCHIAT, V75, P498, DOI 10.4088/JCP.13m08503
   Lysaker PH, 2009, SCHIZOPHR RES, V110, P165, DOI 10.1016/j.schres.2009.01.015
   Malchow B, 2015, SCHIZOPHRENIA BULL, V41, P847, DOI 10.1093/schbul/sbv020
   Marzolini S., 2009, MENT HEALTH PHYS ACT, V2, P29, DOI 10.1016/j.mhpa.2008.11.001
   McCreadie RG, 2005, BRIT J PSYCHIAT, V187, P346, DOI 10.1192/bjp.187.4.346
   McKibbin CL, 2006, SCHIZOPHR RES, V86, P36, DOI 10.1016/j.schres.2006.05.010
   McKibbin CL, 2010, SCHIZOPHR RES, V121, P203, DOI 10.1016/j.schres.2009.09.039
   Melamed Y, 2008, PSYCHIATR REHABIL J, V31, P194, DOI 10.2975/31.3.2008.194.200
   Methapatara W, 2011, PSYCHIAT CLIN NEUROS, V65, P374, DOI 10.1111/j.1440-1819.2011.02225.x
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Mucheru Doreen, 2019, JBI Database System Rev Implement Rep, V17, P1770, DOI 10.11124/JBISRIR-2017-003943
   Newcomer JW, 2007, JAMA-J AM MED ASSOC, V298, P1794, DOI 10.1001/jama.298.15.1794
   Nyboe L, 2019, PSYCHIAT RES, V281, DOI 10.1016/j.psychres.2019.112556
   Ochoa S, 2005, SCHIZOPHR RES, V75, P129, DOI 10.1016/j.schres.2004.06.002
   Oertel-Knöchel V, 2014, EUR ARCH PSY CLIN N, V264, P589, DOI 10.1007/s00406-014-0485-9
   Ohi K, 2019, EUR ARCH PSY CLIN N, V269, P517, DOI 10.1007/s00406-018-0903-5
   Paikkatt B, 2015, INDIAN J PSYCHIAT, V57, P355, DOI 10.4103/0019-5545.171837
   Pajonk FG, 2010, ARCH GEN PSYCHIAT, V67, P133, DOI 10.1001/archgenpsychiatry.2009.193
   Peters JL, 2008, J CLIN EPIDEMIOL, V61, P991, DOI 10.1016/j.jclinepi.2007.11.010
   Poulin MJ, 2007, AUST NZ J PSYCHIAT, V41, P980, DOI 10.1080/00048670701689428
   Ratliff' JC, 2012, COMPR PSYCHIAT, V53, P1028, DOI 10.1016/j.comppsych.2012.02.003
   ROTATORI AF, 1980, PSYCHOL REP, V46, P483, DOI 10.2466/pr0.1980.46.2.483
   Ryu J, 2020, J PSYCHIATR RES, V120, P144, DOI 10.1016/j.jpsychires.2019.10.015
   Sabe M, 2020, GEN HOSP PSYCHIAT, V62, P13, DOI 10.1016/j.genhosppsych.2019.11.002
   Sabe M, 2019, SCHIZOPHR RES, V212, P15, DOI 10.1016/j.schres.2019.07.030
   Sailer P, 2015, BMC PSYCHIATRY, V15, DOI 10.1186/s12888-015-0513-y
   Sawilowsky SS, 2009, J MOD APPL STAT METH, V8, P597, DOI 10.22237/jmasm/1257035100
   Scheewe TW, 2013, ACTA PSYCHIAT SCAND, V127, P464, DOI 10.1111/acps.12029
   Scheewe TW, 2013, EUR NEUROPSYCHOPHARM, V23, P675, DOI 10.1016/j.euroneuro.2012.08.008
   Scocco Paolo, 2006, Eat Behav, V7, P115, DOI 10.1016/j.eatbeh.2005.08.003
   Speyer H, 2016, WORLD PSYCHIATRY, V15, P155, DOI 10.1002/wps.20318
   Stanton R, 2014, CURR SPORT MED REP, V13, P260, DOI 10.1249/JSR.0000000000000069
   Stubbs B, 2018, EUR PSYCHIAT, V54, P124, DOI 10.1016/j.eurpsy.2018.07.004
   Stubbs B, 2016, SCHIZOPHR RES, V176, P431, DOI 10.1016/j.schres.2016.05.017
   Sugawara N, 2018, J PSYCHIATR RES, V97, P77, DOI 10.1016/j.jpsychires.2017.12.002
   Svatkova A, 2015, SCHIZOPHRENIA BULL, V41, P869, DOI 10.1093/schbul/sbv033
   Tosh G, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008567.pub2
   Tumiel E, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00566
   Vancampfort D, 2015, ACTA PSYCHIAT SCAND, V132, P131, DOI 10.1111/acps.12407
   Vancampfort D, 2012, ACTA PSYCHIAT SCAND, V126, P12, DOI 10.1111/j.1600-0447.2012.01865.x
   Vancampfort D, 2019, WORLD PSYCHIATRY, V18, P53, DOI 10.1002/wps.20614
   Vancampfort D, 2017, WORLD PSYCHIATRY, V16, P308, DOI 10.1002/wps.20458
   Vancampfort D, 2016, GEN HOSP PSYCHIAT, V39, P15, DOI 10.1016/j.genhosppsych.2015.11.008
   Vancampfort D, 2013, CLIN REHABIL, V27, P291, DOI 10.1177/0269215512455531
   Vancampfort D, 2012, PSYCHIAT RES, V200, P73, DOI 10.1016/j.psychres.2012.03.046
   Varambally Shivarama, 2012, Indian J Psychiatry, V54, P227, DOI 10.4103/0019-5545.102414
   Ventura J, 2013, SCHIZOPHR RES, V143, P307, DOI 10.1016/j.schres.2012.10.043
   Vera-Garcia E, 2015, PSYCHIAT RES, V229, P828, DOI 10.1016/j.psychres.2015.07.083
   Visceglia E, 2011, J ALTERN COMPLEM MED, V17, P601, DOI 10.1089/acm.2010.0075
   Vogel JS, 2019, PSYCHIAT RES, V279, P295, DOI 10.1016/j.psychres.2019.03.012
   Vreeland B, 2003, PSYCHIAT SERV, V54, P1155, DOI 10.1176/appi.ps.54.8.1155
   Wang PW, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00167
   Ward MC, 2015, J CLIN PSYCHIAT, V76, pE477, DOI 10.4088/JCP.13r08657
   Weber M, 2006, SCHIZOPHR RES, V83, P95, DOI 10.1016/j.schres.2006.01.008
   Wu MK, 2007, PSYCHIAT SERV, V58, P544, DOI 10.1176/appi.ps.58.4.544
   Wu RR, 2008, JAMA-J AM MED ASSOC, V299, P185, DOI 10.1001/jama.2007.56-b
NR 136
TC 61
Z9 64
U1 3
U2 28
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD JUN
PY 2021
VL 125
BP 535
EP 568
DI 10.1016/j.neubiorev.2021.01.005
EA MAR 2021
PG 34
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA RW8DA
UT WOS:000646748800007
PM 33503476
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Cantuária, VL
   Rodrigues, CM
   Dias, IR
   Ottone, VD
   Costa, BO
   Godinho, LF
   Silva, G
   Schetino, MAA
   Rocha-Vieira, E
   Dias-Peixoto, MF
   Honorato-Sampaio, K
AF Cantuaria, Vinicius Lopes
   Rodrigues, Cintia Maria
   Dias, Isabella Rocha
   Ottone, Vinicius de Oliveira
   Costa, Bruna Oliveira
   Godinho, Lourdes Fernanda
   Silva, Gabriela
   Schetino, Marco Antonio Alves
   Rocha-Vieira, Etel
   Dias-Peixoto, Marco Fabricio
   Honorato-Sampaio, Kinulpe
TI Intense Caloric Restriction from Birth Protects the Heart Against
   Ischemia/Reperfusion Injury and Reduces Reactive Oxygen Species in
   Ovariectomized Rats
SO ANTIOXIDANTS
LA English
DT Article
DE menopause; diet; mitochondria; oxidative stress
ID ISCHEMIA-REPERFUSION INJURY; TERM DIETARY RESTRICTION; INDUCED OXIDATIVE
   STRESS; RESVERATROL SUPPLEMENTATION; MYOCARDIAL PROTECTION; ESTROGEN
   REPLACEMENT; INSULIN SENSITIVITY; GENE-EXPRESSION; BLOOD-PRESSURE; AGE
AB This study investigates the cardioprotective effects of intense caloric restriction (ICR) from birth in ovariectomized rats, a model of estrogen deficiency mimicking menopause. Our findings demonstrate that ICR significantly improved both basal and post-ischemic cardiac function, even in the absence of estrogens. The restricted animals exhibited enhanced cardiac contractility and relaxation, particularly after ischemia/reperfusion (I/R) injury, with superior functional recovery compared to control groups. Notably, ICR reduced key cardiometabolic risk factors, including blood pressure, heart rate, and adiposity, while improving glucose tolerance and insulin sensitivity. Additionally, while mitochondrial biogenesis remained unaffected, ICR preserved mitochondrial integrity by reducing the number of damaged mitochondria. This was linked to a reduction in oxidative stress, as evidenced by lower reactive oxygen species (ROS) production in the hearts of restricted animals. These results suggest that ICR offers a protective effect against cardiovascular dysfunction induced by estrogen depletion, potentially through enhanced antioxidant defenses and mitochondrial protection.
C1 [Cantuaria, Vinicius Lopes; Ottone, Vinicius de Oliveira; Schetino, Marco Antonio Alves; Rocha-Vieira, Etel; Honorato-Sampaio, Kinulpe] Univ Fed Vales Jequitinhonha & Mucuri, Fac Med, BR-39100000 Diamantina, MG, Brazil.
   [Cantuaria, Vinicius Lopes; Costa, Bruna Oliveira; Godinho, Lourdes Fernanda; Silva, Gabriela; Rocha-Vieira, Etel; Dias-Peixoto, Marco Fabricio; Honorato-Sampaio, Kinulpe] Univ Fed Vales Jequitinhonha & Mucuri, Programa Posgrad Ciencias Saude, BR-39100000 Diamantina, MG, Brazil.
   [Rodrigues, Cintia Maria; Dias, Isabella Rocha; Dias-Peixoto, Marco Fabricio] Univ Fed Vales Jequitinhonha & Mucuri, Fac Ciencias Biol & Saude, BR-39100000 Diamantina, MG, Brazil.
C3 Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM);
   Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM);
   Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM)
RP Honorato-Sampaio, K (corresponding author), Univ Fed Vales Jequitinhonha & Mucuri, Fac Med, BR-39100000 Diamantina, MG, Brazil.; Honorato-Sampaio, K (corresponding author), Univ Fed Vales Jequitinhonha & Mucuri, Programa Posgrad Ciencias Saude, BR-39100000 Diamantina, MG, Brazil.
EM vinicius.cantuaria@ufvjm.edu.br; cintia.rodrigues@ufvjm.edu.br;
   isabella.dias@ufvjm.edu.br; vinicius.ottone@ufvjm.edu.br;
   bruna.costa@ufvjm.edu.br; lourdes.godinho@ufvjm.edu.br;
   gabriela.silva@ufvjm.edu.br; marco.schetino@ufvjm.edu.br;
   etel.vieira@ufvjm.edu.br; marcofabri@ufvjm.edu.br; kinulpe@ufvjm.edu.br
RI Rodrigues, Cíntia/AIE-8410-2022; Honorato-Sampaio,
   Kinulpe/ACC-5742-2022; DIAS PEIXOTO, MARCO FABRICIO/AAC-7943-2022;
   Silva, Gabriela/MTA-5091-2025; Rocha-Vieira, Etel/A-2524-2017
OI Rocha-Vieira, Etel/0000-0001-6908-7237; Godinho,
   Lourdes/0000-0001-7068-2025; Honorato Sampaio,
   Kinulpe/0000-0002-8154-9606
FU FAPEMIG [APQ-01049-21, APQ-02363-22, APQ-04955-23]; Kinulpe Honorato
   Sampaio is a recipient of Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq) [303206/2022-5]
FX This study was supported by (FAPEMIG) (APQ-01049-21; APQ-02363-22;
   APQ-04955-23), and Kinulpe Honorato Sampaio is a recipient of Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
   (303206/2022-5).
CR Abete P, 2002, AM J PHYSIOL-HEART C, V282, pH1978, DOI 10.1152/ajpheart.00929.2001
   Al-Dhubiab BE, 2020, NUTRIENTS, V12, DOI 10.3390/nu12103186
   Amaral AG, 2022, BBA-MOL BASIS DIS, V1868, DOI 10.1016/j.bbadis.2022.166371
   Anderson RM, 2010, TRENDS ENDOCRIN MET, V21, P134, DOI 10.1016/j.tem.2009.11.005
   Ash CE, 2011, MECH AGEING DEV, V132, P43, DOI 10.1016/j.mad.2010.12.001
   Aydin C, 2007, CELL BIOCHEM FUNCT, V25, P129, DOI 10.1002/cbf.1279
   Aydin C, 2009, INDIAN J EXP BIOL, V47, P24
   Bergamini E, 2007, ANN NY ACAD SCI, V1114, P69, DOI 10.1196/annals.1396.020
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Brinton RD, 2012, ENDOCRINOLOGY, V153, P3571, DOI 10.1210/en.2012-1340
   Broderick TL, 2002, MOL CELL BIOCHEM, V233, P119, DOI 10.1023/A:1015506327849
   Bruss MD, 2010, AM J PHYSIOL-ENDOC M, V298, pE108, DOI 10.1152/ajpendo.00524.2009
   Campos C, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/218749
   Cavallini G, 2001, EXP GERONTOL, V36, P497, DOI 10.1016/S0531-5565(00)00224-2
   Çevikelli-Yakut ZA, 2021, INT J IMPOT RES, V33, P844, DOI 10.1038/s41443-020-00356-w
   Chae SU, 2007, ARCH PHARM RES, V30, P1225, DOI 10.1007/BF02980263
   Chen CN, 2019, GEROSCIENCE, V41, P871, DOI 10.1007/s11357-019-00109-8
   Chen LH, 1996, AGE, V19, P101, DOI 10.1007/BF02434089
   Chen YR, 2014, CIRC RES, V114, P524, DOI 10.1161/CIRCRESAHA.114.300559
   Chou SH, 2010, CARDIOVASC RES, V87, P751, DOI 10.1093/cvr/cvq095
   Cohen HY, 2004, SCIENCE, V305, P390, DOI 10.1126/science.1099196
   Covarrubias AJ, 2021, NAT REV MOL CELL BIO, V22, P119, DOI 10.1038/s41580-020-00313-x
   Covell J.W., 2011, Comprehensive Physiology, DOI [10.1002/cphy.cp020120, DOI 10.1002/CPHY.CP020120]
   Coylewright M, 2008, HYPERTENSION, V51, P952, DOI 10.1161/HYPERTENSIONAHA.107.105742
   Davis SR, 2015, NAT REV DIS PRIMERS, V1, DOI 10.1038/nrdp.2015.4
   de Queiroz KB, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0172103
   Faria MSDN, 2022, MOL BIOL REP, V49, P5883, DOI 10.1007/s11033-022-07370-9
   Debortoli AR, 2017, J MOL ENDOCRINOL, V59, P171, DOI 10.1530/JME-16-0117
   Depre C, 1997, J MOL CELL CARDIOL, V29, P2253, DOI 10.1006/jmcc.1997.0464
   Dosi R, 2014, J CLIN DIAGN RES, V8, P62, DOI 10.7860/JCDR/2014/6457.4009
   Felix ACS, 2019, AUTON NEUROSCI-BASIC, V218, P1, DOI 10.1016/j.autneu.2019.02.002
   Filho JFL, 2015, REV BRAS GINECOL OBS, V37, P152, DOI 10.1590/SO100-720320150005282
   Fontana L, 2007, AM J PHYSIOL-ENDOC M, V293, pE197, DOI 10.1152/ajpendo.00102.2007
   Fontana L, 2015, CELL, V161, P106, DOI 10.1016/j.cell.2015.02.020
   Forster MJ, 2003, FASEB J, V17, P690, DOI 10.1096/fj.02-0533fje
   Guo ZJ, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-27611-6
   Hall JE, 2015, ENDOCRIN METAB CLIN, V44, P485, DOI 10.1016/j.ecl.2015.05.010
   Han XF, 2010, ACTA PHARMACOL SIN, V31, P1111, DOI 10.1038/aps.2010.146
   Hancock CR, 2011, FASEB J, V25, P785, DOI 10.1096/fj.10-170415
   HOLEHAN AM, 1985, MECH AGEING DEV, V32, P179, DOI 10.1016/0047-6374(85)90078-8
   Johnson ML, 2016, DIABETES, V65, P74, DOI 10.2337/db15-0675
   Ketonen J, 2010, HEART VESSELS, V25, P254, DOI 10.1007/s00380-009-1182-x
   Kim C, 2023, ENDOCRIN METAB CLIN, V52, P195, DOI 10.1016/j.ecl.2022.10.005
   Kolodgie FD, 1997, J MOL CELL CARDIOL, V29, P2403, DOI 10.1006/jmcc.1997.0476
   Kostogrys Renata B., 2018, Rocz Panstw Zakl Hig, V69, P37
   Landgren BM, 2004, J CLIN ENDOCR METAB, V89, P2763, DOI 10.1210/jc.2003-030824
   Larson-Meyer DE, 2006, DIABETES CARE, V29, P1337, DOI 10.2337/dc05-2565
   Leuzzi C, 2012, G ITAL CARDIOL, V13, P401, DOI 10.1714/1073.11757
   Lin SJ, 2004, GENE DEV, V18, P12, DOI 10.1101/gad.1164804
   Liu H, 2011, CARDIOVASC RES, V89, P119, DOI 10.1093/cvr/cvq265
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   Mager DE, 2006, FASEB J, V20, P631, DOI 10.1096/fj.05-5263com
   Mansur AP, 2017, INT J CARDIOL, V227, P788, DOI 10.1016/j.ijcard.2016.10.058
   Martin SJ, 2011, DEV CELL, V20, P142, DOI 10.1016/j.devcel.2011.01.016
   Matsushima S, 2015, AM J PHYSIOL-HEART C, V309, pH1375, DOI 10.1152/ajpheart.00053.2015
   Mauvais-Jarvis F, 2013, ENDOCR REV, V34, P309, DOI 10.1210/er.2012-1055
   Melo DD, 2023, REJUV RES, V26, P194, DOI 10.1089/rej.2023.0032
   Melo DS, 2016, FRONT PHYSIOL, V7, DOI 10.3389/fphys.2016.00106
   Melo DS, 2013, APPL PHYSIOL NUTR ME, V38, P879, DOI 10.1139/apnm-2012-0387
   Mendelsohn ME, 1999, NEW ENGL J MED, V340, P1801, DOI 10.1056/NEJM199906103402306
   Mercuro G, 2004, MATURITAS, V47, P131, DOI 10.1016/S0378-5122(03)00252-4
   Merry BJ, 2004, AGING CELL, V3, P7, DOI 10.1046/j.1474-9728.2003.00074.x
   Miller BF, 2012, AGING CELL, V11, P150, DOI 10.1111/j.1474-9726.2011.00769.x
   Miyaki A, 2009, ANGIOLOGY, V60, P351, DOI 10.1177/0003319708325449
   Morimoto K, 2008, ANN NY ACAD SCI, V1148, P213, DOI 10.1196/annals.1410.045
   Morkuniene R, 2010, BBA-BIOENERGETICS, V1797, P1012, DOI 10.1016/j.bbabio.2010.03.027
   Morra EA, 2019, FREE RADICAL BIO MED, V130, P174, DOI 10.1016/j.freeradbiomed.2018.10.406
   Murase T, 2012, HYPERTENSION, V59, P694, DOI 10.1161/HYPERTENSIONAHA.111.180976
   National Research Council, 2011, GUIDE CARE USE LAB A, DOI [DOI 10.17226/12910, 10.17226/12910]
   Newson Louise, 2018, Post Reprod Health, V24, P44, DOI 10.1177/2053369117749675
   Ong SB, 2015, THROMB HAEMOSTASIS, V113, P513, DOI 10.1160/TH14-07-0592
   Parlee SD, 2014, METHOD ENZYMOL, V537, P93, DOI 10.1016/B978-0-12-411619-1.00006-9
   Planavila A, 2012, J MOL CELL CARDIOL, V53, P521, DOI 10.1016/j.yjmcc.2012.07.019
   Reckelhoff JF, 2018, ADV EXP MED BIOL, V1065, P139, DOI 10.1007/978-3-319-77932-4_9
   Rodrigues CM, 2021, LIFE SCI, V275, DOI 10.1016/j.lfs.2021.119411
   Santos RL, 2016, BRAZ J MED BIOL RES, V49, DOI [10.1590/1414-431X20165058, 10.1590/1414-431x20165058]
   Schutte R, 2013, AM J HYPERTENS, V26, P665, DOI 10.1093/ajh/hps119
   Seki S, 2001, MOL CELL BIOCHEM, V216, P111, DOI 10.1023/A:1011067529272
   Shinmura K, 2011, J MOL CELL CARDIOL, V50, P117, DOI 10.1016/j.yjmcc.2010.10.018
   Speakman JR, 2011, MOL ASPECTS MED, V32, P159, DOI 10.1016/j.mam.2011.07.001
   Strehlow K, 2003, CIRC RES, V93, P170, DOI 10.1161/01.RES.0000082334.17947.11
   Sung MMY, 2012, HEART FAIL REV, V17, P707, DOI 10.1007/s10741-011-9293-8
   Tannous C, 2021, ACTA PHYSIOL, V231, DOI 10.1111/apha.13551
   Timmers S, 2011, CELL METAB, V14, P612, DOI 10.1016/j.cmet.2011.10.002
   Villareal DT, 2006, ARCH INTERN MED, V166, P2502, DOI 10.1001/archinte.166.22.2502
   VOOGD A, 1991, FREE RADICAL BIO MED, V11, P71, DOI 10.1016/0891-5849(91)90190-E
   WALFORD RL, 1992, P NATL ACAD SCI USA, V89, P11533, DOI 10.1073/pnas.89.23.11533
   Wang H, 1999, FREE RADICAL BIO MED, V27, P612, DOI 10.1016/S0891-5849(99)00107-0
   Wang MJ, 2006, AM J PHYSIOL-HEART C, V290, pH2204, DOI 10.1152/ajpheart.01219.2005
   Wang YH, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00636
   Watroba M, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.724506
   Wei SY, 2019, NUTR METAB, V16, DOI 10.1186/s12986-019-0388-x
   Wu QJ, 2022, SIGNAL TRANSDUCT TAR, V7, DOI 10.1038/s41392-022-01257-8
   Yamamoto T, 2016, AM J PHYSIOL-HEART C, V310, pH1003, DOI 10.1152/ajpheart.00676.2015
   Yao QY, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms231911384
   Yu BP, 1996, FREE RADICAL BIO MED, V21, P651, DOI 10.1016/0891-5849(96)00162-1
   Zhang J, 2019, J CEREBR BLOOD F MET, V39, P1394, DOI 10.1177/0271678X18785480
NR 97
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD FEB
PY 2025
VL 14
IS 2
AR 169
DI 10.3390/antiox14020169
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA Y1P2M
UT WOS:001429925800001
PM 40002357
OA gold
DA 2025-06-11
ER

PT S
AU Yazici, D
   Sezer, H
AF Yazici, Dilek
   Sezer, Havva
BE Engin, AB
   Engin, A
TI Insulin Resistance, Obesity and Lipotoxicity
SO OBESITY AND LIPOTOXICITY
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
DE Lipotoxicity; Insulin resistance; Type 2 diabetes mellitus; Obesity;
   Fatty acids; Diacylglycerol; Ceramides; Cytokines; Endoplasmic reticulum
   stress
ID TUMOR-NECROSIS-FACTOR; PROTEIN-KINASE-C; ENDOPLASMIC-RETICULUM STRESS;
   HUMAN SKELETAL-MUSCLE; NF-KAPPA-B; FREE FATTY-ACIDS; DEPENDENT
   DIABETES-MELLITUS; ADIPOSE TRIGLYCERIDE LIPASE; JUN NH2-TERMINAL KINASE;
   DIET-INDUCED OBESITY
AB Lipotoxicity, originally used to describe the destructive effects of excess fat accumulation on glucose metabolism, causes functional impairments in several metabolic pathways, both in adipose tissue and peripheral organs, like liver, heart, pancreas and muscle. Lipotoxicity has roles in insulin resistance and pancreatic beta cell dysfunction. Increased circulating levels of lipids and the metabolic alterations in fatty acid utilization and intracellular signaling, have been related to insulin resistance in muscle and liver. Different pathways, like novel protein kinase c pathways and the JNK-1 pathway are involved as the mechanisms of how lipotoxicity leads to insulin resistance in nonadipose tissue organs, such as liver and muscle. Mitochondrial dysfunction plays a role in the pathogenesis of insulin resistance. Endoplasmic reticulum stress, through mainly increased oxidative stress, also plays important role in the etiology of insulin resistance, especially seen in non-alcoholic fatty liver disease. Visceral adiposity and insulin resistance both increase the cardiometabolic risk and lipotoxicity seems to play a crucial role in the pathophysiology of these associations.
C1 [Yazici, Dilek] Koc Univ, Div Endocrinol & Metab, Fac Med, Davutpasa Cad 4, TR-34010 Istanbul, Turkey.
   [Sezer, Havva] Koc Univ, Div Endocrinol & Metab, Fac Med, Istanbul, Turkey.
C3 Koc University; Koc University
RP Yazici, D (corresponding author), Koc Univ, Div Endocrinol & Metab, Fac Med, Davutpasa Cad 4, TR-34010 Istanbul, Turkey.
EM dyazici@ku.edu.tr
RI Sezer, Havva/HNQ-3249-2023
OI Sezer, Havva/0000-0002-2730-7307
CR Aguirre V, 2000, J BIOL CHEM, V275, P9047, DOI 10.1074/jbc.275.12.9047
   Ahmadian M, 2009, DIABETES, V58, P855, DOI 10.2337/db08-1644
   Aon MA, 2014, FRONT PHYSIOL, V5, DOI 10.3389/fphys.2014.00282
   Austin RL, 2008, DIABETES, V57, P2066, DOI 10.2337/db07-0763
   Azen SP, 1998, CONTROL CLIN TRIALS, V19, P217, DOI 10.1016/S0197-2456(97)00151-7
   Badin PM, 2011, DIABETES, V60, P1734, DOI 10.2337/db10-1364
   Bánhegyi G, 2007, FEBS LETT, V581, P3634, DOI 10.1016/j.febslet.2007.04.028
   Bánhegyi G, 2012, ANTIOXID REDOX SIGN, V16, P772, DOI 10.1089/ars.2011.4437
   Barnes PJ, 1997, NEW ENGL J MED, V336, P1066, DOI 10.1056/NEJM199704103361506
   Basantani MK, 2011, J LIPID RES, V52, P318, DOI 10.1194/jlr.M011205
   Bashan N, 2009, PHYSIOL REV, V89, P27, DOI 10.1152/physrev.00014.2008
   Bays H, 2004, J CLIN ENDOCR METAB, V89, P463, DOI 10.1210/jc.2003-030723
   Belfort R, 2005, DIABETES, V54, P1640, DOI 10.2337/diabetes.54.6.1640
   Bilan Phillip J., 2009, Archives of Physiology and Biochemistry, V115, P176, DOI 10.1080/13813450903079314
   Bindokas VP, 2003, J BIOL CHEM, V278, P9796, DOI 10.1074/jbc.M206913200
   Boden G, 2008, DIABETOLOGIA, V51, P1095, DOI 10.1007/s00125-008-1015-y
   Boden G, 2011, CURR OPIN ENDOCRINOL, V18, P139, DOI 10.1097/MED.0b013e3283444b09
   Bouzakri K, 2007, J BIOL CHEM, V282, P7783, DOI 10.1074/jbc.M608602200
   Brady MJ, 1997, J BIOL CHEM, V272, P29698, DOI 10.1074/jbc.272.47.29698
   Brown JEP, 2002, FEBS LETT, V513, P189, DOI 10.1016/S0014-5793(02)02296-2
   Bruce CR, 2009, DIABETES, V58, P550, DOI 10.2337/db08-1078
   Brunner H, 2005, J HYPERTENS, V23, P233, DOI 10.1097/00004872-200502000-00001
   Bruun JM, 2006, AM J PHYSIOL-ENDOC M, V290, pE961, DOI 10.1152/ajpendo.00506.2005
   Butler AE, 2003, DIABETES, V52, P102, DOI 10.2337/diabetes.52.1.102
   Caimari A, 2007, OBESITY, V15, P591, DOI 10.1038/oby.2007.563
   Cao J, 2012, MOL CELL BIOCHEM, V364, P115, DOI 10.1007/s11010-011-1211-9
   Chan CB, 2001, DIABETES, V50, P1302, DOI 10.2337/diabetes.50.6.1302
   Chen WQ, 2010, HEPATOLOGY, V52, P1134, DOI 10.1002/hep.23812
   Chibalin AV, 2008, CELL, V132, P375, DOI 10.1016/j.cell.2007.12.035
   Chtioui H, 2007, LIVER INT, V27, P764, DOI 10.1111/j.1478-3231.2007.01524.x
   Ciaraldi TP, 1995, J CLIN INVEST, V96, P2820, DOI 10.1172/JCI118352
   Cline GW, 1999, NEW ENGL J MED, V341, P240, DOI 10.1056/NEJM199907223410404
   Cnop M, 2008, BIOCHEM SOC T, V36, P348, DOI 10.1042/BST0360348
   Coletta DK, 2008, AM J PHYSIOL-ENDOC M, V294, pE910, DOI 10.1152/ajpendo.00607.2007
   Consitt LA, 2009, IUBMB LIFE, V61, P47, DOI 10.1002/iub.142
   Corcoran MP, 2007, AM J CLIN NUTR, V85, P662
   Cucak H, 2014, J LEUKOCYTE BIOL, V95, P149, DOI 10.1189/jlb.0213075
   Cusi K, 2000, J CLIN INVEST, V105, P311, DOI 10.1172/JCI7535
   de Alvaro C, 2004, J BIOL CHEM, V279, P17070, DOI 10.1074/jbc.M312021200
   DeFronzo RA, 2010, DIABETOLOGIA, V53, P1270, DOI 10.1007/s00125-010-1684-1
   DEFRONZO RA, 1992, DIABETES CARE, V15, P318, DOI 10.2337/diacare.15.3.318
   Deng SP, 2004, DIABETES, V53, P624, DOI 10.2337/diabetes.53.3.624
   DENT P, 1990, NATURE, V348, P302, DOI 10.1038/348302a0
   Di Gregorio GB, 2005, DIABETES, V54, P2305, DOI 10.2337/diabetes.54.8.2305
   Dresner A, 1999, J CLIN INVEST, V103, P253, DOI 10.1172/JCI5001
   Duckworth W, 2009, NEW ENGL J MED, V360, P129, DOI 10.1056/NEJMoa0808431
   Evans JL, 2002, ENDOCR REV, V23, P599, DOI 10.1210/er.2001-0039
   Fonseca SG, 2011, TRENDS ENDOCRIN MET, V22, P266, DOI 10.1016/j.tem.2011.02.008
   Franckhauser S, 2008, DIABETOLOGIA, V51, P1306, DOI 10.1007/s00125-008-0998-8
   Frangioudakis G, 2008, J ENDOCRINOL, V197, P277, DOI 10.1677/JOE-07-0623
   Gao D, 2010, J BIOL CHEM, V285, P29965, DOI 10.1074/jbc.M110.128694
   Gao ZG, 2007, AM J PHYSIOL-ENDOC M, V292, pE84, DOI 10.1152/ajpendo.00178.2006
   Garg R, 2003, CURR DRUG TARGETS, V4, P487, DOI 10.2174/1389450033490920
   Garvey WT, 1998, J CLIN INVEST, V101, P2377, DOI 10.1172/JCI1557
   Gerich JE, 2003, MAYO CLIN PROC, V78, P447, DOI 10.4065/78.4.447
   Ghosh J, 2009, TOXICOL APPL PHARM, V240, P73, DOI 10.1016/j.taap.2009.07.008
   Gillingham LG, 2011, LIPIDS, V46, P209, DOI 10.1007/s11745-010-3524-y
   Golden SH, 2002, DIABETES, V51, P3069, DOI 10.2337/diabetes.51.10.3069
   Goodpaster BH, 2001, J CLIN ENDOCR METAB, V86, P5755, DOI 10.1210/jc.86.12.5755
   Greenberg AS, 2011, TRENDS ENDOCRIN MET, V22, P195, DOI 10.1016/j.tem.2011.04.002
   Gregor MF, 2009, DIABETES, V58, P693, DOI 10.2337/db08-1220
   Griffin ME, 1999, DIABETES, V48, P1270, DOI 10.2337/diabetes.48.6.1270
   Haemmerle G, 2006, SCIENCE, V312, P734, DOI 10.1126/science.1123965
   Hajri T, 2002, J CLIN INVEST, V109, P1381, DOI [10.1172/JCI200214596, 10.1172/JCI0214596]
   He SQ, 2010, J BIOL CHEM, V285, P6706, DOI 10.1074/jbc.M109.064501
   HENRY RR, 1993, DIABETES CARE, V16, P21, DOI 10.2337/diacare.16.1.21
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Holland WL, 2007, CELL METAB, V5, P167, DOI 10.1016/j.cmet.2007.01.002
   Holland WL, 2011, J CLIN INVEST, V121, P1858, DOI 10.1172/JCI43378
   Holmes AG, 2008, J ENDOCRINOL, V198, P367, DOI 10.1677/JOE-08-0113
   Hommelberg PPH, 2009, AM J PHYSIOL-ENDOC M, V296, pE114, DOI 10.1152/ajpendo.00436.2007
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   HOTAMISLIGIL GS, 1995, J CLIN INVEST, V95, P2409, DOI 10.1172/JCI117936
   Huang C, 2005, J BIOL CHEM, V280, P19426, DOI 10.1074/jbc.M412317200
   Huang YC, 2010, P NATL ACAD SCI USA, V107, P7892, DOI 10.1073/pnas.1003585107
   Ikeda Y, 2001, DIABETES, V50, P584, DOI 10.2337/diabetes.50.3.584
   JeBailey L, 2007, DIABETES, V56, P394, DOI 10.2337/db06-0823
   Jenkins CM, 2004, J BIOL CHEM, V279, P48968, DOI 10.1074/jbc.M407841200
   Jornayvaz FR, 2011, P NATL ACAD SCI USA, V108, P5748, DOI 10.1073/pnas.1103451108
   Joseph JW, 2002, DIABETES, V51, P3211, DOI 10.2337/diabetes.51.11.3211
   Jourdan T, 2013, NAT MED, V19, P1132, DOI 10.1038/nm.3265
   Jové M, 2006, ENDOCRINOLOGY, V147, P552, DOI 10.1210/en.2005-0440
   Kantartzis K, 2009, DIABETES, V58, P2616, DOI 10.2337/db09-0279
   Kashyap S, 2003, DIABETES, V52, P2461, DOI 10.2337/diabetes.52.10.2461
   Kashyap SR, 2004, AM J PHYSIOL-ENDOC M, V287, pE537, DOI 10.1152/ajpendo.00541.2003
   KAWAKAMI M, 1987, J BIOCHEM, V101, P331, DOI 10.1093/oxfordjournals.jbchem.a121917
   KELLERER M, 1995, J CLIN INVEST, V96, P6, DOI 10.1172/JCI118073
   Kelley DE, 2002, DIABETES, V51, P2944, DOI 10.2337/diabetes.51.10.2944
   KERN PA, 1995, J CLIN INVEST, V95, P2111, DOI 10.1172/JCI117899
   Kershaw EE, 2006, DIABETES, V55, P148, DOI 10.2337/diabetes.55.1.148
   Kewalramani G, 2010, CURR OPIN CLIN NUTR, V13, P382, DOI 10.1097/MCO.0b013e32833aabd9
   Kim HJ, 2004, DIABETES, V53, P1060, DOI 10.2337/diabetes.53.4.1060
   Kim JY, 2006, AM J PHYSIOL-ENDOC M, V291, pE115, DOI 10.1152/ajpendo.00317.2005
   Kim JK, 2004, J CLIN INVEST, V114, P823, DOI 10.1172/JCI200422230
   Kim JK, 2004, J CLIN INVEST, V113, P756, DOI 10.1172/JCI200418917
   Kim JK, 2001, P NATL ACAD SCI USA, V98, P7522, DOI 10.1073/pnas.121164498
   Kosteli A, 2010, J CLIN INVEST, V120, P3466, DOI 10.1172/JCI42845
   Kotronen A, 2009, DIABETOLOGIA, V52, P1056, DOI 10.1007/s00125-009-1285-z
   Koves TR, 2008, CELL METAB, V7, P45, DOI 10.1016/j.cmet.2007.10.013
   KRAEGEN EW, 1991, DIABETES, V40, P1397, DOI 10.2337/diabetes.40.11.1397
   Krauss S, 2003, J CLIN INVEST, V112, P1831, DOI 10.1172/JCI200319774
   Krssak M, 2000, J CLIN ENDOCR METAB, V85, P748, DOI 10.1210/jc.85.2.748
   Lam TKT, 2002, AM J PHYSIOL-ENDOC M, V283, pE682, DOI 10.1152/ajpendo.00038.2002
   Laurencikiene J, 2007, J LIPID RES, V48, P1069, DOI 10.1194/jlr.M600471-JLR200
   Lee HY, 2011, HEPATOLOGY, V54, P1650, DOI 10.1002/hep.24571
   Lee MW, 2010, CELL METAB, V11, P331, DOI 10.1016/j.cmet.2010.02.016
   Li Y, 2004, J BIOL CHEM, V279, P45304, DOI 10.1074/jbc.C400186200
   Li ZZ, 2008, HEPATOLOGY, V47, P1495, DOI 10.1002/hep.22183
   LILLIOJA S, 1988, NEW ENGL J MED, V318, P1217, DOI 10.1056/NEJM198805123181901
   LILLIOJA S, 1993, NEW ENGL J MED, V329, P1988, DOI 10.1056/NEJM199312303292703
   Liu L, 2007, J CLIN INVEST, V117, P1679, DOI 10.1172/JCI30565
   Liu PS, 2004, J BIOL CHEM, V279, P3787, DOI 10.1074/jbc.M311945200
   Lowell BB, 2005, SCIENCE, V307, P384, DOI 10.1126/science.1104343
   Maechler P, 2001, NATURE, V414, P807, DOI 10.1038/414807a
   Mantzaris MD, 2011, FEBS J, V278, P519, DOI 10.1111/j.1742-4658.2010.07972.x
   Montagnani M, 2001, J BIOL CHEM, V276, P30392, DOI 10.1074/jbc.M103702200
   Moro C, 2009, J CLIN ENDOCR METAB, V94, P3440, DOI 10.1210/jc.2009-0053
   Muoio DM, 2010, BBA-MOL CELL BIOL L, V1801, P281, DOI 10.1016/j.bbalip.2009.11.007
   Nagle CA, 2007, J BIOL CHEM, V282, P14807, DOI 10.1074/jbc.M611550200
   Nakamura S, 2009, J BIOL CHEM, V284, P14809, DOI 10.1074/jbc.M901488200
   NARUSE K, 1994, ARTERIOSCLER THROMB, V14, P746, DOI 10.1161/01.ATV.14.5.746
   Neschen S, 2005, CELL METAB, V2, P55, DOI 10.1016/j.cmet.2005.06.006
   Nguyen MTA, 2007, J BIOL CHEM, V282, P35279, DOI 10.1074/jbc.M706762200
   Nieto-Vazquez I, 2008, DIABETES, V57, P3211, DOI 10.2337/db07-1062
   Nivala AM, 2013, METABOLISM, V62, P753, DOI 10.1016/j.metabol.2012.12.001
   Olefsky JM, 2010, ANNU REV PHYSIOL, V72, P219, DOI 10.1146/annurev-physiol-021909-135846
   Orellana M, 2006, HEPATOL RES, V34, P57, DOI 10.1016/j.hepres.2005.10.001
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Patti ME, 2003, P NATL ACAD SCI USA, V100, P8466, DOI 10.1073/pnas.1032913100
   Petersen KF, 2003, SCIENCE, V300, P1140, DOI 10.1126/science.1082889
   Petersen KF, 2010, NEW ENGL J MED, V362, P1082, DOI 10.1056/NEJMoa0907295
   Pick A, 1998, DIABETES, V47, P358, DOI 10.2337/diabetes.47.3.358
   Pickup JC, 1998, DIABETOLOGIA, V41, P1241, DOI 10.1007/s001250051058
   PILLAY TS, 1990, BIOCHEM SOC T, V18, P494, DOI 10.1042/bst0180494
   Poitout V, 2002, ENDOCRINOLOGY, V143, P339, DOI 10.1210/en.143.2.339
   Potashnik R, 2003, DIABETOLOGIA, V46, P639, DOI 10.1007/s00125-003-1097-5
   Powell DJ, 2003, MOL CELL BIOL, V23, P7794, DOI 10.1128/MCB.23.21.7794-7808.2003
   Prentki M, 2002, DIABETES, V51, pS405, DOI 10.2337/diabetes.51.2007.S405
   Puigserver P, 2003, ENDOCR REV, V24, P78, DOI 10.1210/er.2002-0012
   Qiao AJ, 2011, HEPATOLOGY, V54, P509, DOI 10.1002/hep.24402
   Ragheb R, 2009, BIOCHEM BIOPH RES CO, V389, P211, DOI 10.1016/j.bbrc.2009.08.106
   Randhawa VK, 2008, J BIOL CHEM, V283, P27208, DOI 10.1074/jbc.M804282200
   RANDLE PJ, 1963, LANCET, V1, P785
   Rhodes CJ, 2005, SCIENCE, V307, P380, DOI 10.1126/science.1104345
   Richardson DK, 2005, J BIOL CHEM, V280, P10290, DOI 10.1074/jbc.M408985200
   Robinson LE, 2013, LIPIDS, V48, P319, DOI 10.1007/s11745-013-3774-6
   Romeo S, 2008, NAT GENET, V40, P1461, DOI 10.1038/ng.257
   RUDERMAN NB, 1990, P NATL ACAD SCI USA, V87, P1411, DOI 10.1073/pnas.87.4.1411
   Sabio G, 2008, SCIENCE, V322, P1539, DOI 10.1126/science.1160794
   Samocha-Bonet D, 2010, TRENDS ENDOCRIN MET, V21, P83, DOI 10.1016/j.tem.2009.09.008
   Samokhvalov V, 2009, AM J PHYSIOL-ENDOC M, V296, pE37, DOI 10.1152/ajpendo.90667.2008
   Samuel VT, 2012, CELL, V148, P852, DOI 10.1016/j.cell.2012.02.017
   Savage DB, 2007, PHYSIOL REV, V87, P507, DOI 10.1152/physrev.00024.2006
   Seifert EL, 2010, J BIOL CHEM, V285, P5748, DOI 10.1074/jbc.M109.026203
   Shi H, 2006, J CLIN INVEST, V116, P3015, DOI 10.1172/JCI28898
   SHULMAN GI, 1990, NEW ENGL J MED, V322, P223, DOI 10.1056/NEJM199001253220403
   Skovbro M, 2008, DIABETOLOGIA, V51, P1253, DOI 10.1007/s00125-008-1014-z
   STEINBERG HO, 1994, J CLIN INVEST, V94, P1172, DOI 10.1172/JCI117433
   STONE DB, 1969, METABOLIS, V18, P620, DOI 10.1016/0026-0495(69)90097-3
   Stone SJ, 2009, J BIOL CHEM, V284, P5352, DOI 10.1074/jbc.M805768200
   Straczkowski M, 2007, DIABETOLOGIA, V50, P2366, DOI 10.1007/s00125-007-0781-2
   Summers SA, 2006, PROG LIPID RES, V45, P42, DOI 10.1016/j.plipres.2005.11.002
   SUN XJ, 1992, J BIOL CHEM, V267, P22662
   TAKAYAMA S, 1988, J BIOL CHEM, V263, P3440
   Tang T, 2010, J BIOL CHEM, V285, P4637, DOI 10.1074/jbc.M109.068007
   Taniguchi CM, 2006, NAT REV MOL CELL BIO, V7, P85, DOI 10.1038/nrm1837
   Teruel T, 2001, DIABETES, V50, P2563, DOI 10.2337/diabetes.50.11.2563
   Thrush AB, 2009, J CLIN ENDOCR METAB, V94, P5053, DOI 10.1210/jc.2008-2565
   Timmers S, 2008, PHYSIOL BEHAV, V94, P242, DOI 10.1016/j.physbeh.2007.12.002
   Tsukumo DML, 2007, DIABETES, V56, P1986, DOI 10.2337/db06-1595
   Tuncman G, 2006, P NATL ACAD SCI USA, V103, P10741, DOI 10.1073/pnas.0603509103
   TURINSKY J, 1990, J BIOL CHEM, V265, P7933
   Tyra HM, 2012, MOL BIOL CELL, V23, P811, DOI 10.1091/mbc.E11-12-1011
   Unger RH, 2003, TRENDS ENDOCRIN MET, V14, P398, DOI 10.1016/j.tem.2003.09.008
   UNGER RH, 1995, DIABETES, V44, P863, DOI 10.2337/diabetes.44.8.863
   Varma V, 2009, AM J PHYSIOL-ENDOC M, V296, pE1300, DOI 10.1152/ajpendo.90885.2008
   Vettor R, 2009, AM J PHYSIOL-ENDOC M, V297, pE987, DOI 10.1152/ajpendo.00229.2009
   Vial G, 2011, J HEPATOL, V54, P348, DOI 10.1016/j.jhep.2010.06.044
   Videla LA, 2004, CLIN SCI, V106, P261, DOI 10.1042/CS20030285
   Volmer R, 2013, P NATL ACAD SCI USA, V110, P4628, DOI 10.1073/pnas.1217611110
   VONDRA K, 1977, DIABETOLOGIA, V13, P527, DOI 10.1007/BF01234508
   Walther TC, 2012, ANNU REV BIOCHEM, V81, P687, DOI 10.1146/annurev-biochem-061009-102430
   Walther TC, 2009, BBA-MOL CELL BIOL L, V1791, P459, DOI 10.1016/j.bbalip.2008.10.009
   Wang CCL, 2004, DIABETES, V53, P2735, DOI 10.2337/diabetes.53.11.2735
   Wang H, 2009, DIABETES, V58, P116, DOI 10.2337/db07-1839
   WARRAM JH, 1990, ANN INTERN MED, V113, P909, DOI 10.7326/0003-4819-113-12-909
   Watson ML, 2009, BIOCHEM J, V417, P791, DOI 10.1042/BJ20081149
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Wellen KE, 2003, J CLIN INVEST, V112, P1785, DOI 10.1172/JCI20514
   Weltman MD, 1998, HEPATOLOGY, V27, P128, DOI 10.1002/hep.510270121
   Wende AR, 2012, CURR HYPERTENS REP, V14, P517, DOI 10.1007/s11906-012-0307-2
   WHITE MF, 1988, CELL, V54, P641, DOI 10.1016/S0092-8674(88)80008-4
   Wu JW, 2011, HEPATOLOGY, V54, P122, DOI 10.1002/hep.24338
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yamamoto Y, 2004, TRENDS BIOCHEM SCI, V29, P72, DOI 10.1016/j.tibs.2003.12.003
   Ye RS, 2010, DIABETES, V59, P6, DOI 10.2337/db09-0755
   Yu CL, 2002, J BIOL CHEM, V277, P50230, DOI 10.1074/jbc.M200958200
   Yuan MS, 2001, SCIENCE, V293, P1673, DOI 10.1126/science.1061620
   Zaid H, 2008, BIOCHEM J, V413, P201, DOI 10.1042/BJ20080723
   Zámbó V, 2013, WORLD J HEPATOL, V5, P550, DOI 10.4254/wjh.v5.i10.550
   Zeng GY, 2000, CIRCULATION, V101, P1539, DOI 10.1161/01.CIR.101.13.1539
   Zhang KZ, 2011, EMBO J, V30, P1357, DOI 10.1038/emboj.2011.52
   Zhang XM, 2011, DIABETES, V60, P486, DOI 10.2337/db10-0650
   Zhang Y, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-81
NR 204
TC 348
Z9 384
U1 10
U2 77
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 0065-2598
EI 2214-8019
BN 978-3-319-48382-5; 978-3-319-48380-1
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2017
VL 960
BP 277
EP 304
DI 10.1007/978-3-319-48382-5_12
D2 10.1007/978-3-319-48382-5
PG 28
WC Endocrinology & Metabolism; Medicine, Research & Experimental;
   Physiology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine; Physiology
GA BS6WL
UT WOS:000753914500013
PM 28585204
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Sohi, G
   Revesz, A
   Hardy, DB
AF Sohi, Gurjeev
   Revesz, Andrew
   Hardy, Daniel B.
TI Nutritional mismatch in postnatal life of low birth weight rat offspring
   leads to increased phosphorylation of hepatic eukaryotic initiation
   factor 2 α in adulthood
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Fetal programming; Thrifty phenotype; Low protein diet; Metabolic
   syndrome; Protein translation; Growth; Endoplasmic reticulum stress;
   Predictive adaptive response hypothesis
ID ENDOPLASMIC-RETICULUM STRESS; XBP1 MESSENGER-RNA; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; EARLY ORIGINS; EARLY GROWTH; PROTEIN; EXPRESSION;
   PRETERM; ADIPOSE
AB Objective. Epidemiological studies have established that low birth weight offspring, when faced with a nutritional mismatch in postnatal life, have an increased risk of developing the metabolic syndrome. Our laboratory and others have demonstrated that maternal protein restriction (MPR) leads to high cholesterol and insulin resistance in the offspring due to impaired liver function, though the underlying molecular mechanisms remain elusive. Recent in vitro studies have associated decreased phosphorylation of Akt1 (Serine 473), a marker of insulin sensitivity, with increased phosphorylation of eukaryotic initiation factor (eIF)-2 alpha (Serine 51), a key regulator of protein translation attenuation. The main aim of the study was to determine whether nutritional mismatch in MPR offspring leads to elevated phospho-eIF2 alpha (Ser51) levels in the liver.
   Materials/Methods. To investigate if this occurs long-term in MPR offspring, pregnant Wistar rats were fed a control (20%) protein diet (control) or a low (8%) protein diet during pregnancy and postnatal life (LP1), or during pregnancy and lactation (LP2).
   Results. At postnatal day 130, LP2 offspring exhibited increases in hepatic phosphorylation of eIF2 alpha (Ser51) concomitant with decreases in the phosphorylation of Akt1 (Ser473), while LP1 offspring exhibited the converse relationship. Interestingly, in embryonic day 19 livers derived from control or MPR pregnancy, no changes in eIF2 alpha (Ser51) or Ak1 (Ser473) phosphorylation were observed.
   Conclusion. Collectively, our data provide robust evidence that phosphorylation of eIF2 alpha (Ser51) is inversely correlated with phosphorylated Akt1 (Ser473) in vivo. Moreover, this study demonstrates that this inverse relationship is adversely influenced in these MPR offspring by a mismatch in the postnatal nutritional environment. (c) 2013 Elsevier Inc. All rights reserved.
C1 Univ Western Ontario, Childrens Hlth Res Inst, London, ON N6A 5C1, Canada.
   Univ Western Ontario, Lawson Hlth Res Inst, Dept Obstet & Gynecol & Physiol & Pharmacol, London, ON N6A 5C1, Canada.
C3 Western University (University of Western Ontario); Western University
   (University of Western Ontario); University Western Ontario Hospital
RP Hardy, DB (corresponding author), Univ Western Ontario, Dept Physiol & Pharmacol, London, ON N6A 5C1, Canada.
EM Daniel.Hardy@schulich.uwo.ca
RI Hardy, Daniel/GYU-8976-2022
OI Hardy, Daniel/0000-0001-5445-273X
FU CIHR Operating Grant [MOP 111001]; Natural Sciences and Engineering
   Research Council of Canada
FX Supported by: CIHR Operating Grant (MOP 111001) and Natural Sciences and
   Engineering Research Council of Canada.
CR Achard CS, 2012, ENDOCRINOLOGY, V153, P2164, DOI 10.1210/en.2011-1881
   Aridor M, 2007, ADV DRUG DELIVER REV, V59, P759, DOI 10.1016/j.addr.2007.06.002
   Boubred F, 2009, AM J PHYSIOL-RENAL, V297, pF943, DOI 10.1152/ajprenal.90704.2008
   Bozhko H. Kh., 1993, Ukrainskii Biokhimicheskii Zhurnal, V65, P95
   Burns SP, 1997, J CLIN INVEST, V100, P1768, DOI 10.1172/JCI119703
   Chamson-Reig A, 2009, EXP BIOL MED, V234, P1425, DOI 10.3181/0902-RM-69
   CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1006/abio.1987.9999
   Chukwuma C Sr, 1998, J Cardiovasc Risk, V5, P11, DOI 10.1097/00043798-199802000-00002
   da Luz G, 2011, EUR J APPL PHYSIOL, V111, P2015, DOI 10.1007/s00421-010-1802-2
   Desai M, 2007, AM J PHYSIOL-REG I, V293, pR2306, DOI 10.1152/ajpregu.00783.2006
   Gregor MF, 2007, J LIPID RES, V48, P1905, DOI 10.1194/jlr.R700007-JLR200
   Guan HY, 2005, AM J PHYSIOL-ENDOC M, V288, pE663, DOI 10.1152/ajpendo.00461.2004
   HALES CN, 1992, DIABETOLOGIA, V35, P595, DOI 10.1093/ije/dyt133
   Hales CN, 2001, BRIT MED BULL, V60, P5, DOI 10.1093/bmb/60.1.5
   Hirota Morihiko, 2006, Journal of Toxicological Sciences, V31, P149, DOI 10.2131/jts.31.149
   Jennings BJ, 1999, FEBS LETT, V448, P4, DOI 10.1016/S0014-5793(99)00336-1
   Kimball SR, 1999, INT J BIOCHEM CELL B, V31, P25, DOI 10.1016/S1357-2725(98)00128-9
   Langley-Evans SC, 2005, MECH AGEING DEV, V126, P804, DOI 10.1016/j.mad.2005.03.003
   Lee SI, 2012, J PERIODONTAL RES, V47, P299, DOI 10.1111/j.1600-0765.2011.01432.x
   Malhi H, 2011, J HEPATOL, V54, P795, DOI 10.1016/j.jhep.2010.11.005
   Matthews SG, 2002, TRENDS ENDOCRIN MET, V13, P373, DOI 10.1016/S1043-2760(02)00690-2
   Mounir Z, 2011, SCI SIGNAL, V4, DOI 10.1126/scisignal.2001630
   Nuesken KD, 2008, ENDOCRINOLOGY, V149, P1056, DOI 10.1210/en.2007-0891
   Ozanne SE, 2004, NATURE, V427, P411, DOI 10.1038/427411b
   Pereira S, 2008, DIABETES, V57, P56, DOI 10.2337/db07-0887
   Petrik J, 1999, ENDOCRINOLOGY, V140, P4861, DOI 10.1210/en.140.10.4861
   Proud CG, 2005, SEMIN CELL DEV BIOL, V16, P3, DOI 10.1016/j.semcdb.2004.11.004
   Rickard IJ, 2007, TRENDS ENDOCRIN MET, V18, P94, DOI 10.1016/j.tem.2007.02.004
   Ron D, 2007, NAT REV MOL CELL BIO, V8, P519, DOI 10.1038/nrm2199
   Rueda-Clausen CF, 2011, SEMIN REPROD MED, V29, P197, DOI 10.1055/s-0031-1275520
   SASAKI A, 1982, J NUTR SCI VITAMINOL, V28, P543, DOI 10.3177/jnsv.28.543
   Singhal A, 2004, LANCET, V363, P1642, DOI 10.1016/S0140-6736(04)16210-7
   Singhal A, 2003, LANCET, V361, P1089, DOI 10.1016/S0140-6736(03)12895-4
   Singhal A, 2002, AM J CLIN NUTR, V75, P993, DOI 10.1093/ajcn/75.6.993
   Singhal A, 2001, LANCET, V357, P413, DOI 10.1016/S0140-6736(00)04004-6
   Singhal A, 2004, LANCET, V363, P1571, DOI 10.1016/S0140-6736(04)16198-9
   Sohi G, 2011, MOL ENDOCRINOL, V25, P785, DOI 10.1210/me.2010-0395
   Vo TX, 2012, REPROD SCI, V19, p118A
   Vo T, 2012, J CELL COMMUN SIGNAL, V6, P139, DOI 10.1007/s12079-012-0165-3
   Yoshida H, 2001, CELL, V107, P881, DOI 10.1016/S0092-8674(01)00611-0
   Yung HW, 2012, FASEB J, V26, P1970, DOI 10.1096/fj.11-190082
NR 41
TC 16
Z9 18
U1 0
U2 7
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD OCT
PY 2013
VL 62
IS 10
BP 1367
EP 1374
DI 10.1016/j.metabol.2013.05.002
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 226LJ
UT WOS:000325037400004
PM 23768545
DA 2025-06-11
ER

PT J
AU Vlajinac, H
   Marinkovic, J
   Maksimovic, M
   Kocev, N
   Vasiljevic, N
   Backovic, D
   Radak, D
AF Vlajinac, Hristina
   Marinkovic, Jelena
   Maksimovic, Milos
   Kocev, Nikola
   Vasiljevic, Nadja
   Backovic, Dusan
   Radak, Djordje
TI Health-related quality of life among patients with symptomatic carotid
   disease
SO POSTGRADUATE MEDICAL JOURNAL
LA English
DT Article
ID TRANSIENT ISCHEMIC ATTACK; STROKE PATIENTS; DEPRESSION; ENDARTERECTOMY;
   POPULATION; SURVIVORS; OUTCOMES; IMPACT; ADULTS; SF-36
AB Objectives To evaluate health-related quality of life (HRQoL) in patients with symptomatic carotid disease (amaurosis fugax, transient ischaemic attack, stroke); to compare it with that of the general population; to explore whether HRQoL depends on the severity of the disease and to investigate the possible association between some demographic and clinical characteristics of patients and HRQoL.
   Methods This cross-sectional study involved 175 patients with symptomatic carotid atherosclerotic disease who were referred for endarterectomy between January 2011 and December 2011. HRQoL was measured using Medical Outcome Survey Short Form 36 (SF-36).
   Results In comparison to both referent populations, patients with carotid disease had significantly lower mean SF-36 scores for role-physical (41.6 vs. 61.5 and 67.8), social functioning (65.4 vs. 73.8 and 80.0), role-emotional (48.2 vs. 68.6 and 80.5) and mental health (51.5 vs. 61.9 and 66.0). The SF-36 scores were significantly lower in female patients with carotid disease than in men (for role-physical 32.3 vs. 46.5; for bodily pain 57.0 vs. 73.0; for general health 55.6 vs. 61.5; for vitality 55.4 vs. 60.1; for social functioning 57.1 vs. 69.8 and for role-emotional 37.2 vs. 54.1). Significantly lower SF-36 scores were also found in patient with comorbidity (for physical functioning 68.1 vs. 77.7; for role-physical 35.1 vs. 52.3; for bodily pain 62.6 vs. 75.4; for general health 56.8 vs. 63.8; for social functioning 61.9 vs. 71.0, for role-emotional 41.6 vs. 59.1 and for mental health 52.5 vs 49.8). In a multivariable analysis, education, occupation, body mass index, metabolic syndrome and severity of the disease had a weak influence on patients' HRQoL, while age, marital status, smoking, alcohol consumption, physical activity and the degree of carotid stenosis had no effect on patients' HRQoL. The SF-36 scores did not substantially change after adjustment for confounding variables.
   Conclusions Patients with symptomatic carotid disease had poorer HRQoL, especially its mental components, than the general population. The severity of the disease was significantly associated only with the SF-36 role-physical subscale. HRQoL in patients with symptomatic carotid disease was poorer in women than in men, and was not affected by age and other demographic and clinical characteristics of patients.
C1 [Vlajinac, Hristina] Univ Belgrade, Fac Med, Inst Epidemiol, Belgrade 11000, Serbia.
   [Marinkovic, Jelena; Kocev, Nikola] Univ Belgrade, Fac Med, Inst Med Stat & Informat, Belgrade 11000, Serbia.
   [Maksimovic, Milos; Vasiljevic, Nadja; Backovic, Dusan] Univ Belgrade, Fac Med, Inst Hyg & Med Ecol, Belgrade 11000, Serbia.
   [Radak, Djordje] Univ Belgrade, Fac Med, Dept Vasc Surg, Dedinje Cardiovasc Inst, Belgrade 11000, Serbia.
C3 University of Belgrade; University of Belgrade; University of Belgrade;
   University of Belgrade
RP Vlajinac, H (corresponding author), Univ Belgrade, Fac Med, Inst Epidemiol, Visegradska 26, Belgrade 11000, Serbia.
EM kristiv@eunet.rs
RI Maksimović, Miloš/ABF-7728-2021
OI Vlajinac, Hristina/0000-0002-8239-2989; Maksimovic,
   Milos/0000-0002-6346-3171; Backovic, Dusan/0000-0002-3373-3628
FU Ministry of Education and Science, Serbia [III41002]
FX This work was supported by the Ministry of Education and Science,
   Serbia, through contract No III41002 (2011-2014).
CR Abelha FJ, 2008, BMC CARDIOVASC DISOR, V8, DOI 10.1186/1471-2261-8-33
   Allender S., 2008, EUROPEAN CARDIOVASCU
   Almborg AH, 2009, J REHABIL MED, V41, P48, DOI 10.2340/16501977-0287
   Astrom M, 1996, STROKE, V27, P270, DOI 10.1161/01.STR.27.2.270
   Barnett HJM, 1998, NEW ENGL J MED, V339, P1415, DOI 10.1056/NEJM199811123392002
   Brown DW, 2010, N AM J MED SCI, V2, P60, DOI 10.4297/najms.2010.260
   Carod-Artal J, 2000, STROKE, V31, P2995, DOI 10.1161/01.STR.31.12.2995
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   Cohen DJ, 2011, J AM COLL CARDIOL, V58, P1557, DOI 10.1016/j.jacc.2011.05.054
   Dennis M, 2000, J NEUROL NEUROSUR PS, V68, P47, DOI 10.1136/jnnp.68.1.47
   Eriksson M, 2004, STROKE, V35, P936, DOI 10.1161/01.STR.0000121643.86762.9a
   Gargano JW, 2007, STROKE, V38, P2541, DOI 10.1161/STROKEAHA.107.485482
   Glader EL, 2001, STROKE, V32, P2124, DOI 10.1161/hs0901.095724
   Goodwin RD, 2008, J GERIATR PSYCH NEUR, V21, P41, DOI 10.1177/0891988707311041
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Hackett ML, 2000, STROKE, V31, P440, DOI 10.1161/01.STR.31.2.440
   Hopman WM, 2004, CAN J PUBLIC HEALTH, V95, P387, DOI 10.1007/BF03405153
   Kong K. H., 2006, SMJ Singapore Medical Journal, V47, P213
   Luijendijk HJ, 2011, STROKE, V42, P1857, DOI 10.1161/STROKEAHA.110.604405
   Mayo NE, 2002, ARCH PHYS MED REHAB, V83, P1035, DOI 10.1053/apmr.2002.33984
   Naess H, 2006, STROKE, V37, P1232, DOI 10.1161/01.STR.0000217652.42273.02
   Nor Azlin M.N., 2009, MALAYS J COMMUNITY H, V15, P83
   Patel MD, 2006, AGE AGEING, V35, P273, DOI 10.1093/ageing/afj074
   Regensteiner JG, 2008, VASC MED, V13, P15, DOI 10.1177/1358863X07084911
   Sersic DM, 2006, CROAT MED J, V47, P95
   SIPETIC SB, 2001, 1 YUG C ATH MAY BELG, P178
   Stolker JM, 2010, JACC-CARDIOVASC INTE, V3, P515, DOI 10.1016/j.jcin.2010.02.009
   Sturm JW, 2004, STROKE, V35, P2340, DOI 10.1161/01.STR.0000141977.18520.3b
   Tengs TO, 2001, STROKE, V32, P964, DOI 10.1161/01.STR.32.4.964
   Tziallas D., 2012, Health Science Journal, V6, P116
   Vasiljevic N, 2008, HEALTH QUAL LIFE OUT, V6, DOI 10.1186/1477-7525-6-106
   Ware J.E., 2003, SF 36 HLTH SURVEY MA
   Ware JE, 2000, SPINE, V25, P3130, DOI 10.1097/00007632-200012150-00008
   Wu KY, 2010, AM J GERIAT PSYCHIAT, V18, P382, DOI 10.1097/JGP.0b013e3181cabab1
   Xie JP, 2006, STROKE, V37, P2567, DOI 10.1161/01.STR.0000240506.34616.10
   Yamakawa Y, 2005, PSYCHIAT CLIN NEUROS, V59, P705, DOI 10.1111/j.1440-1819.2005.01440.x
NR 36
TC 11
Z9 11
U1 0
U2 9
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0032-5473
EI 1469-0756
J9 POSTGRAD MED J
JI Postgrad. Med. J.
PD JAN
PY 2013
VL 89
IS 1047
BP 8
EP 13
DI 10.1136/postgradmedj-2012-131005
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 057KI
UT WOS:000312561700003
PM 23043129
DA 2025-06-11
ER

PT J
AU Qiu, LJ
   Gao, CY
   Wang, HA
   Ren, Y
   Li, JX
   Li, MJ
   Du, XL
   Li, WJ
   Zhang, J
AF Qiu, Linjie
   Gao, Chunyang
   Wang, Haonan
   Ren, Yan
   Li, Jixin
   Li, Meijie
   Du, Xinlei
   Li, Wenjie
   Zhang, Jin
TI Effects of dietary polyphenol curcumin supplementation on metabolic,
   inflammatory, and oxidative stress indices in patients with metabolic
   syndrome: a systematic review and meta-analysis of randomized controlled
   trials
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE curcumin; turmeric; metabolic syndrome; inflammation; meta-analysis
ID DOUBLE-BLIND; WEIGHT-LOSS; OBESITY
AB Objective: The aim was to conduct a systematic review and meta-analysis for assessing the effectiveness and safety of dietary polyphenol curcumin supplement on metabolic, inflammatory, and oxidative stress indices in patients with metabolic syndrome (MetS).
   Methods: A comprehensive search for clinical trials was conducted in the following scientific databases: PubMed, SCOPUS, Cochrane Library, EMBASE, Web of Science, and China Biological Medicine. Randomized controlled trials (RCTs) evaluating the efficacy and safety of curcumin supplement for MetS were identified. A random-effects meta-analysis was performed using inverse variance, and efficacy was expressed as mean difference (MD) with 95% confidence interval (CI). The metabolic syndrome markers that were evaluated in the present study included waist circumference (WC), fasting blood sugar (FBS), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), tumor necrosis factor-a (TNF-a), interleukin 6 (IL-6), C-reactive protein (CRP), ultrasensitive c-reactive protein (hsCRP), and malondialdehyde (MDA). By employing the Cochrane tool, RCTs were assessed for bias risk.
   Results: A total of 785 participants from 13 RCTs were included, with intervention durations ranging from 4 to 12 weeks. Compared with the control group, the curcumin group had positive effects on WC (MD = -2.16, 95% CI: -3.78 to -0.54, p = 0.009, seven studies), FBS (MD = -8.6, 95% CI: -15.45 to -1.75, p = 0.01, nine studies), DBP (MD = -2.8, 95% CI: -4.53 to - 1.06, p = 0.002, five studies), HDL-C (MD = 4.98, 95% CI: 2.58 to 7.38, p < 0.0001, eight studies), TNF-a (MD = -12.97, 95% CI: -18.37 to -7.57, p < 0.00001, two studies), CRP (MD = - 1.24, 95% CI: -1.71 to -0.77, p < 0.00001, two studies), and MDA (MD = -2.35, 95% CI: -4.47 to -0.24, p = 0.03, three studies). These improvements were statistically significant. Meanwhile, there was no significant improvement in SBP (MD = -4.82, 95% CI: -9.98 to 0.35, p = 0.07, six studies), TG (MD = 1.28, 95% CI: -3.75 to 6.30, p = 0.62, eight studies), IL-6 (MD = -1.5, 95% CI: -3.97 to 0.97, p = 0.23, two studies), or hsCRP (MD = -1.10, 95% CI: -4.35 to 2.16, p < 0.51, two studies). FBS, SBP, HDL-C, IL-6, CRP, hsCRP, and MDA had a relatively high heterogeneity.
   Conclusion: Curcumin exhibited promising potential in enhancing markers associated with metabolic syndrome, including inflammation. However, additional studies are required to confirm such findings since the included evidence is limited and has a relatively high heterogeneity.
C1 [Qiu, Linjie; Wang, Haonan; Ren, Yan; Li, Jixin; Li, Meijie; Du, Xinlei; Li, Wenjie; Zhang, Jin] China Acad Chinese Med Sci, Xiyuan Hosp, Beijing, Peoples R China.
   [Gao, Chunyang] Peking Univ, Dept Special Needs Int Med, Int Hosp, Beijing, Peoples R China.
C3 Xiyuan Hospital, CACMS; China Academy of Chinese Medical Sciences;
   Peking University
RP Zhang, J (corresponding author), China Acad Chinese Med Sci, Xiyuan Hosp, Beijing, Peoples R China.
EM zjmzy2000@hotmail.com
RI Li, Jixin/GSN-5182-2022; Li, Wenjie/ABB-7358-2021; LI,
   Meijie/ABA-9381-2021
FU Science and Technology Innovation Project of the Chinese Academy of
   Traditional Chinese Medicine [CI2021A03005]
FX Funding This study was funded by the Science and Technology Innovation
   Project of the Chinese Academy of Traditional Chinese Medicine
   (CI2021A03005).
CR Adibian M, 2019, PHYTOTHER RES, V33, P1374, DOI 10.1002/ptr.6328
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Alidadi M, 2021, ADV EXP MED BIOL, V1308, P1, DOI 10.1007/978-3-030-64872-5_1
   Amin F, 2015, COMPLEMENT THER MED, V23, P165, DOI 10.1016/j.ctim.2015.01.008
   Armstrong A, 2022, OBES REV, V23, DOI 10.1111/obr.13446
   Azhdari M, 2019, PHYTOTHER RES, V33, P1289, DOI 10.1002/ptr.6323
   Bateni Z, 2021, PHYTOTHER RES, V35, P3945, DOI 10.1002/ptr.7109
   Bateni Z, 2022, J HERB MED, V31, DOI 10.1016/j.hermed.2021.100531
   Bondia-Pons I, 2012, J PHYSIOL BIOCHEM, V68, P701, DOI 10.1007/s13105-012-0154-2
   Cicero AFG, 2020, EUR J NUTR, V59, P477, DOI 10.1007/s00394-019-01916-7
   Dehzad MJ, 2023, PHYTOTHER RES, V37, P1703, DOI 10.1002/ptr.7800
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Di Pierro F, 2015, EUR REV MED PHARMACO, V19, P4195
   Engin AB, 2017, ADV EXP MED BIOL, V960, P327, DOI 10.1007/978-3-319-48382-5_14
   Finelli C, 2013, AGEING RES REV, V12, P996, DOI 10.1016/j.arr.2013.05.007
   Frühbeck G, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-06997-0
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Grandl G, 2018, SEMIN IMMUNOPATHOL, V40, P215, DOI 10.1007/s00281-017-0666-5
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Higgins JP, 2011, BMJ, V343, pd5928, DOI [DOI 10.1136/BMJ.D5928, 10.1136/bmj.d5928.22008217]
   Hosseini H, 2023, PHYTOTHER RES, V37, P1212, DOI 10.1002/ptr.7730
   Ramírez-Manent JI, 2023, NUTRIENTS, V15, DOI 10.3390/nu15020257
   Jabczyk M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124440
   Jazayeri-Tehrani SA, 2019, NUTR METAB, V16, DOI 10.1186/s12986-019-0331-1
   Karimi A, 2022, FOOD FUNCT, V13, P6596, DOI [10.1039/d1fo03746c, 10.1039/D1FO03746C]
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Kotha RR, 2019, MOLECULES, V24, DOI 10.3390/molecules24162930
   Lara M, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-638
   li Osali A., 2018, J SEMNAN UNIVESITY M, V20, P503
   Lukkunaprasit T, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-33023-3
   Makki Kassem, 2013, ISRN Inflamm, V2013, P139239, DOI 10.1155/2013/139239
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   Mokgalaboni K, 2021, FOOD FUNCT, V12, P12235, DOI [10.1039/d1fo02696h, 10.1039/D1FO02696H]
   Musazadeh V, 2022, J FUNCT FOODS, V99, DOI 10.1016/j.jff.2022.105357
   Musazadeh V, 2022, NUTR METAB CARDIOVAS, V32, P2493, DOI 10.1016/j.numecd.2022.07.021
   Nct, 2021, EFF NUTR SUPPL TURM
   Nurcahyanti ADR, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.891339
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Osali A, 2020, DIABETOL METAB SYNDR, V12, DOI 10.1186/s13098-020-00532-4
   Page MJ, 2021, BMJ-BRIT MED J, V372, DOI [10.1136/bmj.n71, 10.1136/bmj.n160]
   Panahi Y, 2016, BIOMED PHARMACOTHER, V82, P578, DOI 10.1016/j.biopha.2016.05.037
   Panahi Y, 2015, CLIN NUTR, V34, P1101, DOI 10.1016/j.clnu.2014.12.019
   Rezaianzadeh A, 2012, INT J PREVENTIVE MED, V3, P552
   Saberi-Karimian M., 2018, Comparative Clinical Pathology, V27, P555, DOI 10.1007/s00580-017-2624-y
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Salimi Avansar M., 2017, J. Ardabil Univ. Med. Sci, V17, P299
   Scherer PE, 2016, DIABETES, V65, P1452, DOI 10.2337/db16-0339
   Shah M, 2022, ENVIRON SCI POLLUT R, V29, P43732, DOI 10.1007/s11356-022-20137-w
   Sherling DH, 2017, J CARDIOVASC PHARM T, V22, P365, DOI 10.1177/1074248416686187
   Son DH, 2022, ADV CLIN CHEM, V110, P37, DOI 10.1016/bs.acc.2022.06.002
   Sookoian S, 2011, CURR HYPERTENS REP, V13, P149, DOI 10.1007/s11906-010-0164-9
   Unamuno X, 2018, EUR J CLIN INVEST, V48, DOI 10.1111/eci.12997
   Unhapipatpong C, 2023, AM J CLIN NUTR, V117, P1005, DOI 10.1016/j.ajcnut.2023.03.006
   Vafaeipour Z, 2022, J INTEGR MED-JIM, V20, P193, DOI 10.1016/j.joim.2022.02.008
   Vollono L, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092169
   Wedell-Neergaard AS, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194991
   White CM, 2019, PHARMACOL RES, V146, DOI 10.1016/j.phrs.2019.104280
   Wu LY, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102307
   Yang YS, 2014, PHYTOTHER RES, V28, P1770, DOI 10.1002/ptr.5197
   Zhang H., 2019, Mod. J. Integr. Tradit. Chin. West. Med, V28, P1103, DOI DOI 10.3969/J.ISSN.1008-8849.2019.10.019
NR 60
TC 23
Z9 24
U1 1
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JUL 14
PY 2023
VL 14
AR 1216708
DI 10.3389/fendo.2023.1216708
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA N4QY9
UT WOS:001036889400001
PM 37522129
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pouwer, F
   Nijpels, G
   Beekman, AT
   Dekker, JM
   van Dam, RM
   Heine, RJ
   Snoek, FJ
AF Pouwer, F
   Nijpels, G
   Beekman, AT
   Dekker, JM
   van Dam, RM
   Heine, RJ
   Snoek, FJ
TI Fat food for a bad mood.: Could we treat and prevent depression in type
   2 diabetes by means of ω-3 polyunsaturated fatty acids?: A review of the
   evidence
SO DIABETIC MEDICINE
LA English
DT Article
DE diabetes; depression; omega-3 polyunsaturated fatty acids;
   phospholipids; metabolic syndrome
ID PRELIMINARY DOUBLE-BLIND; IMPAIRED GLUCOSE-TOLERANCE; FISH-OIL
   SUPPLEMENTATION; PLACEBO-CONTROLLED TRIAL; CORONARY-ARTERY-DISEASE;
   BLOOD-CELL MEMBRANES; MAJOR DEPRESSION; CARDIOVASCULAR-DISEASE;
   DIETARY-FAT; OMEGA-3-FATTY-ACID LEVELS
AB Aims Evidence strongly suggests that depression is a common complication of Type 2 diabetes mellitus. However, there is considerable room to improve the effectiveness of pharmacological antidepressant agents, as in only 50-60% of the depressed subjects with diabetes does pharmacotherapy lead to remission of depression. The aim of the present paper was to review whether polyunsaturated fatty acids (PUFA) of the omega-3 family could be used for the prevention and treatment of depression in Type 2 diabetes.
   Methods MEDLINE database and published reference lists were used to identify studies that examined the associations between omega-3 PUFA and depression. To examine potential side-effects, such as on glycaemic control, studies regarding the use of omega-3 supplements in Type 2 diabetes were also reviewed.
   Results Epidemiological and clinical studies suggest that a high intake of omega-3 PUFA protects against the development of depression. There is also some evidence that a low intake of omega-3 is associated with an increased risk of Type 2 diabetes, but the results are less conclusive. Results from randomized controlled trials in non-diabetic subjects with major depression show that eicosapentaenoic acid is an effective adjunct treatment of depression in diabetes, while docosahexanoic acid is not. Moreover, consumption of omega-3 PUFA reduces the risk of cardiovascular disease and may therefore indirectly decrease depression in Type 2 diabetes, via the reduction of cardiovascular complications.
   Conclusions Supplementation with omega-3 PUFA, in particular eicosapentaenoic acid, may be a safe and helpful tool to reduce the incidence of depression and to treat depression in Type 2 diabetes. Further studies are now justified to test these hypotheses in patients with Type 2 diabetes.
C1 Vrije Univ Amsterdam, Med Ctr, EMGO Inst, Amsterdam, Netherlands.
   Vrije Univ Amsterdam, Med Ctr, Dept Med Psychol, Amsterdam, Netherlands.
   Vrije Univ Amsterdam, Med Ctr, Fac Earth & Life Sci, Dept Nutr & Hlth, Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; Vrije
   Universiteit Amsterdam
RP Pouwer, F (corresponding author), Vrije Univ Amsterdam, Med Ctr, EMGO Inst, Amsterdam, Netherlands.
EM pouwer@vumc.nl
RI Beekman, Aartjan T./LUZ-6919-2024; van Dam, Rob/F-9674-2010; van Dam,
   Rob/A-6693-2009
OI Pouwer, Frans/0000-0002-8172-9818; Snoek, Frank/0000-0001-9563-6762; van
   Dam, Rob/0000-0002-7354-8734
CR ADAMS PB, 1996, LIPIDS S, V31, P157
   Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   APPEL LJ, 1993, ARCH INTERN MED, V153, P1429, DOI 10.1001/archinte.153.12.1429
   Assies J, 2004, PROSTAG LEUKOTR ESS, V70, P349, DOI 10.1016/j.plefa.2003.12.009
   Assies J, 2001, BIOL PSYCHIAT, V49, P510, DOI 10.1016/S0006-3223(00)00986-0
   BLOCK ER, 1987, AM J PHYSIOL, V253, P672
   Burg MM, 2001, J CLIN PSYCHOL, V57, P1323, DOI 10.1002/jclp.1100
   Eaton WW, 1996, DIABETES CARE, V19, P1097, DOI 10.2337/diacare.19.10.1097
   Edwards R, 1998, J AFFECT DISORDERS, V48, P149, DOI 10.1016/S0165-0327(97)00166-3
   FESKENS EJM, 1993, ANN NY ACAD SCI, V683, P9
   FESKENS EJM, 1995, DIABETES CARE, V18, P1104, DOI 10.2337/diacare.18.8.1104
   FESKENS EJM, 1991, DIABETES CARE, V14, P935, DOI 10.2337/diacare.14.11.935
   Forrest KYZ, 2000, ATHEROSCLEROSIS, V148, P159, DOI 10.1016/S0021-9150(99)00217-8
   Franz MJ, 2002, DIABETES CARE, V25, P148, DOI [10.2337/diacare.25.1.202, 10.2337/diacare.25.1.148]
   Frasure-Smith N, 2004, BIOL PSYCHIAT, V55, P891, DOI 10.1016/j.biopsych.2004.01.021
   Friedberg CE, 1998, DIABETES CARE, V21, P494, DOI 10.2337/diacare.21.4.494
   Golden SH, 2004, DIABETES CARE, V27, P429, DOI 10.2337/diacare.27.2.429
   Hakkarainen R, 2004, AM J PSYCHIAT, V161, P567, DOI 10.1176/appi.ajp.161.3.567
   Harris W S, 1997, J Cardiovasc Risk, V4, P385, DOI 10.1097/00043798-199710000-00011
   Hibbeln JR, 1998, BIOL PSYCHIAT, V44, P235, DOI 10.1016/S0006-3223(98)00141-3
   HIBBELN JR, 1995, AM J CLIN NUTR, V62, P1
   Hibbeln JR, 1998, LANCET, V351, P1213, DOI 10.1016/S0140-6736(05)79168-6
   Horrobin DF, 1999, PROSTAG LEUKOTR ESS, V60, P217, DOI 10.1054/plef.1999.0037
   Hu FB, 2001, DIABETOLOGIA, V44, P805, DOI 10.1007/s001250100547
   Jacka E, 2004, NUTR NEUROSCI, V7, P101, DOI 10.1080/10284150410001710438
   Jacobson AM, 2002, INT REV NEUROBIOL, V51, P455, DOI 10.1016/S0074-7742(02)51013-8
   Jorgensen ME, 2002, DIABETES CARE, V25, P1766, DOI 10.2337/diacare.25.10.1766
   Katon WJ, 2003, BIOL PSYCHIAT, V54, P216, DOI 10.1016/S0006-3223(03)00273-7
   Kawakami N, 1999, DIABETES CARE, V22, P1071, DOI 10.2337/diacare.22.7.1071
   King H, 1998, DIABETES CARE, V21, P1414, DOI 10.2337/diacare.21.9.1414
   Kris-Etherton PM, 2003, ARTERIOSCL THROM VAS, V23, P151, DOI 10.1161/01.ATV.0000057393.97337.AE
   Kris-Etherton PM, 2002, CIRCULATION, V106, P2747, DOI 10.1161/01.CIR.0000038493.65177.94
   Lloyd CE, 1996, ARTERIOSCL THROM VAS, V16, P720, DOI 10.1161/01.ATV.16.6.720
   Lund EK, 1999, ANN NUTR METAB, V43, P290, DOI 10.1159/000012797
   Lustman PJ, 2002, J PSYCHOSOM RES, V53, P917, DOI 10.1016/S0022-3999(02)00416-6
   Maes M, 1998, BIOL PSYCHIAT, V43, P313
   Maes M, 1999, PSYCHIAT RES, V85, P275, DOI 10.1016/S0165-1781(99)00014-1
   Maes M, 1996, J AFFECT DISORDERS, V38, P35, DOI 10.1016/0165-0327(95)00092-5
   Mamalakis G, 2004, PROSTAG LEUKOTR ESS, V70, P495, DOI 10.1016/j.plefa.2003.10.005
   Mamalakis G, 2002, PROSTAG LEUKOTR ESS, V67, P311, DOI 10.1054/plef.2002.0435
   Marangell LB, 2003, AM J PSYCHIAT, V160, P996, DOI 10.1176/appi.ajp.160.5.996
   Marshall JA, 1997, DIABETOLOGIA, V40, P430, DOI 10.1007/s001250050697
   Meyer KA, 2001, DIABETES CARE, V24, P1528, DOI 10.2337/diacare.24.9.1528
   Montori VM, 2000, DIABETES CARE, V23, P1407, DOI 10.2337/diacare.23.9.1407
   MULROW CD, 1995, ANN INTERN MED, V122, P913, DOI 10.7326/0003-4819-122-12-199506150-00004
   Murray CJL, 1997, LANCET, V349, P1498, DOI 10.1016/S0140-6736(96)07492-2
   Musselman DL, 2003, BIOL PSYCHIAT, V54, P317, DOI 10.1016/S0006-3223(03)00569-9
   Nemets B, 2002, AM J PSYCHIAT, V159, P477, DOI 10.1176/appi.ajp.159.3.477
   Peet M, 2003, PROSTAG LEUKOTR ESS, V69, P477, DOI 10.1016/j.plefa.2003.08.020
   Peet M, 1998, BIOL PSYCHIAT, V43, P315, DOI 10.1016/S0006-3223(97)00206-0
   Peet M, 2002, ARCH GEN PSYCHIAT, V59, P913, DOI 10.1001/archpsyc.59.10.913
   Penninx BWJH, 2001, ARCH GEN PSYCHIAT, V58, P221, DOI 10.1001/archpsyc.58.3.221
   Peyrot M, 1999, DIABETES CARE, V22, P448, DOI 10.2337/diacare.22.3.448
   Pouwer F, 2003, DIABETOLOGIA, V46, P892, DOI 10.1007/s00125-003-1124-6
   Rubin RR, 2002, DIABETES-METAB RES, V18, P173, DOI 10.1002/dmrr.292
   Rudisch B, 2003, BIOL PSYCHIAT, V54, P227, DOI 10.1016/S0006-3223(03)00587-0
   Rugulies R, 2002, AM J PREV MED, V23, P51, DOI 10.1016/S0749-3797(02)00439-7
   Salmerón J, 2001, AM J CLIN NUTR, V73, P1019
   Saydah SH, 2003, DIABETES-METAB RES, V19, P202, DOI 10.1002/dmrr.353
   Simopoulos AP, 1999, PROSTAG LEUKOTR ESS, V60, P421, DOI 10.1016/S0952-3278(99)80023-4
   Stoll AL, 1999, ARCH GEN PSYCHIAT, V56, P407, DOI 10.1001/archpsyc.56.5.407
   Su KP, 2003, EUR NEUROPSYCHOPHARM, V13, P267, DOI 10.1016/S0924-977X(03)00032-4
   Suzuki S, 2004, BRIT J CANCER, V90, P787, DOI 10.1038/sj.bjc.6601621
   Takahata K, 1998, BIOSCI BIOTECH BIOCH, V62, P2079, DOI 10.1271/bbb.62.2079
   Talbot F, 2000, DIABETES CARE, V23, P1556, DOI 10.2337/diacare.23.10.1556
   Tanskanen A, 2001, PSYCHIATR SERV, V52, P529, DOI 10.1176/appi.ps.52.4.529
   Tanskanen A, 2001, ARCH GEN PSYCHIAT, V58, P512, DOI 10.1001/archpsyc.58.5.512
   Tiemeier H, 2003, AM J CLIN NUTR, V78, P40, DOI 10.1093/ajcn/78.1.40
   Timonen M, 2004, J AFFECT DISORDERS, V82, P447, DOI 10.1016/j.jad.2004.02.002
   TOFT I, 1995, ANN INTERN MED, V123, P911, DOI 10.7326/0003-4819-123-12-199512150-00003
   van Dam RM, 2002, DIABETES CARE, V25, P417, DOI 10.2337/diacare.25.3.417
   Vessby B, 2001, DIABETOLOGIA, V44, P312, DOI 10.1007/s001250051620
   Weber P, 2000, NUTR METAB CARDIOVAS, V10, P28
NR 73
TC 18
Z9 23
U1 0
U2 21
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 0742-3071
J9 DIABETIC MED
JI Diabetic Med.
PD NOV
PY 2005
VL 22
IS 11
BP 1465
EP 1475
DI 10.1111/j.1464-5491.2005.01661.x
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 976ZL
UT WOS:000232772100002
PM 16241908
DA 2025-06-11
ER

PT J
AU Hao, XZ
   Yuan, J
   Dong, HX
AF Hao, Xiuzhen
   Yuan, Jie
   Dong, Huixiao
TI Salidroside prevents diabetes-induced cognitive impairment via
   regulating the Rho pathway
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE salidroside; diabetes; cognitive impairment; Rho; nuclear factor-B
ID CARDIOMETABOLIC RISK; GLYCEMIC CONTROL; DEFICITS; INTERVENTION;
   INFLAMMATION; DYSFUNCTION; ACTIVATION; EXERCISE; STRESS; ADULTS
AB In previous years, it has been found that Rhodiola has a wide range of pharmacological effects in diseases of the cardiovascular system, as it can remove superoxide anions and hydroxyl radicals in chemical reactions. Behavioral assessment was used to measure cognitive impairment. Inflammation, oxidative stress and caspase-3 activity were measured using commercial kits. Western blot analysis was used to measure Rho/Rho-associated kinase (ROCK)/sirtuin 1 (SIRT1)/nuclear factor (NF)-B protein expression. The objective of the present study was to investigate the protective effect of salidroside on diabetes and diabetes-induced cognitive impairment. The results of the study demonstrated that salidroside prevented cognitive impairment, decreased serum blood glucose levels and increased body weight, reduced fasting blood glucose levels and blood lipid levels, and inhibited oxidative stress, inflammation and nerve cell apoptosis in the diabetic rat model. Salidroside suppressed ROCK/ SIRT1 NF-B pathway and protein expression in the diabetic rats. These data showed that salidroside prevented diabetes-induced cognitive impairment by regulating the Rho/ROCK/SIRT1/NF-B pathway.
C1 [Hao, Xiuzhen; Dong, Huixiao] Jining 1 Peoples Hosp, Dept Neurosurg, 6 Jiankang Rd, Jining 272000, Shandong, Peoples R China.
   [Yuan, Jie] North China Univ Sci & Technol, Inst Mental Hlth, Tangshan 063009, Hebei, Peoples R China.
C3 North China University of Science & Technology
RP Dong, HX (corresponding author), Jining 1 Peoples Hosp, Dept Neurosurg, 6 Jiankang Rd, Jining 272000, Shandong, Peoples R China.
EM dovlbm13964@126.com
CR [Anonymous], 2014, J AM MED DIR ASS
   Baluchnejadmojarad T, 2017, EUR J PHARMACOL, V794, P69, DOI 10.1016/j.ejphar.2016.11.033
   Cheng L, 2016, BIOCHEM BIOPH RES CO, V477, P685, DOI 10.1016/j.bbrc.2016.06.120
   Du LL, 2014, AGE, V36, P613, DOI 10.1007/s11357-013-9592-1
   Fiocco AJ, 2013, CAN J DIABETES, V37, P214, DOI 10.1016/j.jcjd.2013.03.369
   Forouhi NG, 2016, DIABETES OBES METAB, V18, P392, DOI 10.1111/dom.12625
   Gao J, 2016, METAB BRAIN DIS, V31, P771, DOI 10.1007/s11011-016-9813-2
   Golokhvast Kirill, 2014, Asian Pacific Journal of Tropical Biomedicine, V4, P362, DOI 10.12980/APJTB.4.2014C1197
   Inouye Jillian, 2015, Hawaii J Med Public Health, V74, P360
   Jacoba L, 2017, J ALZHEIMERS DIS, V56, P379, DOI 10.3233/JAD-160875
   Karashima S, 2016, CLIN EXP HYPERTENS, V38, P565, DOI 10.3109/10641963.2016.1151526
   Khare P, 2017, NEUROMOL MED, V19, P101, DOI 10.1007/s12017-016-8434-6
   Kuhad A, 2009, PHARMACOL BIOCHEM BE, V92, P251, DOI 10.1016/j.pbb.2008.12.012
   Leguina-Ruzzi A, 2015, METAB SYNDR RELAT D, V13, P373, DOI 10.1089/met.2015.0061
   Li DM, 2015, DIABETES RES CLIN PR, V110, P224, DOI 10.1016/j.diabres.2015.05.051
   Li H, 2017, EVID-BASED COMPL ALT, V2017
   Luchsinger JA, 2016, J ALZHEIMERS DIS, V51, P501, DOI 10.3233/JAD-150493
   Luo F, 2017, BIOMED PHARMACOTHER, V86, P155, DOI 10.1016/j.biopha.2016.12.032
   Ma LY, 2011, ALZ DIS ASSOC DIS, V25, P352, DOI 10.1097/WAD.0b013e31820ce536
   Ma ZH, 2016, INT IMMUNOPHARMACOL, V38, P377, DOI 10.1016/j.intimp.2016.06.023
   Murdock KW, 2016, PSYCHONEUROENDOCRINO, V71, P102, DOI 10.1016/j.psyneuen.2016.05.006
   Sun P, 2016, MOLECULES, V21, DOI 10.3390/molecules21111490
   Sun ZJ, 2016, BMC CARDIOVASC DISOR, V16, DOI 10.1186/s12872-016-0372-6
   Tian X, 2016, BRAIN RES, V1650, P1, DOI 10.1016/j.brainres.2016.08.032
   Wang J, 2014, ONCOL LETT, V7, P1159, DOI 10.3892/ol.2014.1863
   Watson NA, 2015, CONTEMP CLIN TRIALS, V45, P217, DOI 10.1016/j.cct.2015.11.001
   Watzlawick R, 2014, JAMA NEUROL, V71, P91, DOI 10.1001/jamaneurol.2013.4684
   Xu Jing, 2013, Zhong Nan Da Xue Xue Bao Yi Xue Ban, V38, P882, DOI 10.3969/j.issn.1672-7347.2013.09.003
   Yin ZJ, 2015, BEHAV BRAIN RES, V292, P288, DOI 10.1016/j.bbr.2015.06.024
   Zhao Z, 2013, BEHAV BRAIN RES, V238, P44, DOI 10.1016/j.bbr.2012.10.018
   Zhu LP, 2016, NEUROPHARMACOLOGY, V103, P134, DOI 10.1016/j.neuropharm.2015.12.007
NR 31
TC 19
Z9 19
U1 1
U2 26
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD JAN
PY 2019
VL 19
IS 1
BP 678
EP 684
DI 10.3892/mmr.2018.9621
PG 7
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA HF7PE
UT WOS:000454431000074
PM 30387819
OA Bronze
DA 2025-06-11
ER

PT J
AU Piegza, M
   Pudlo, R
   Badura-Brzoza, K
   Piegza, J
   Szygula-Jurkiewicz, B
   Gorczyca, P
   Polonski, L
AF Piegza, Magdalena
   Pudlo, Robert
   Badura-Brzoza, Karina
   Piegza, Jacek
   Szygula-Jurkiewicz, Bozena
   Gorczyca, Piotr
   Polonski, Lech
TI Dynamics of anxiety in women undergoing coronary angiography
SO KARDIOLOGIA POLSKA
LA English
DT Article
DE anxiety; coronary artery disease; coronary angiography; somatoform
   disorders; cardiac syndrome X
ID HEART-DISEASE; PHOBIC ANXIETY; CHEST-PAIN; RISK; ARTERIOGRAPHY;
   REVASCULARIZATION; SYMPTOMS; FEARS; MEN
AB Background: Anxiety is a common and serious problem in ischaemic heart disease. Anxiety-associated somatisation disorders may imitate symptoms of coronary artery disease or coexist with ischaemic heart disease. Despite multiple visits to various specialists, patients with somatisation are frequently misdiagnosed and therefore mistreated. Identification of patients with anxiety disorders among patients complaining of chest pain is a prerequisite for appropriate management. By its nature, coronary angiography is a diagnostic test that can give rise to anxiety. However, dynamics of anxiety in this setting may be variable depending on coexisting mental disorders.
   Aim: The purpose of this study was to determine whether the presence of significant atherosclerotic lesions in coronary arteries affects anxiety level changes following coronary angiography.
   Methods: A group of 90 female patients who underwent coronary angiography was divided into two groups: the first one included 48 patients without significant coronary stenoses, and the other one included 42 patients with confirmed significant atherosclerotic lesions. Dynamics of anxiety level changes from the hospital admission, through the post-examination period, until 6 to 9 months after coronary angiography was evaluated with three-time measurement of anxiety using the Spielberger's State-Trait Anxiety Inventory. In addition, intensity of anxiety as a trait was measured twice (at the first and the third examination).
   Results: The highest intensity of anxiety as a state was noted in both groups at the first measurement. A significant reduction in anxiety was observed at the second measurement, more pronounced in the group without significant coronary lesions. At the third measurement, women with confirmed significant coronary lesions showed the lowest level of anxiety, while the level of anxiety increased compared to the second measurement in the group of patients without significant coronary lesions. At the third measurement, women without significant coronary lesions showed a significantly higher level of anxiety compared to the group with significant coronary lesions. Intensity of anxiety as a trait was significantly lower at the final measurement in the group of patients with confirmed significant coronary stenoses.
   Conclusions: In women demonstrating no significant atherosclerotic lesions in coronary angiography, anxiety does not resolve permanently but reappears after several months. In this group, is seems justified to consider a diagnosis of an anxiety disorder in the form of a somatoform disorder. Those patients should be offered psychiatric therapy.
C1 [Piegza, Magdalena; Pudlo, Robert; Badura-Brzoza, Karina; Gorczyca, Piotr] Med Univ Silesia, Div Dent Zabrze, Sch Med, Chair & Clin Dept Psychiat Tarnowskie Gory, Katowice, Poland.
   [Piegza, Jacek; Szygula-Jurkiewicz, Bozena; Polonski, Lech] Med Univ Silesia, Sch Med, Div Dent Zabrze, Chair & Clin Dept Cardiol 3, Katowice, Poland.
C3 Medical University of Silesia; Medical University of Silesia
RP Pudlo, R (corresponding author), Chair & Clin Dept Psychiat Tarnowskie Gory, Ul Pyskowicka 49, PL-42612 Tarnowskie Gory, Poland.
EM rpudlo@sum.edu.pl
RI Pudlo, Robert/HKF-1660-2023
OI Piegza, Magdalena/0000-0001-7228-5349; Piegza,
   Magdalena/0000-0002-8009-7118; Badura-Brzoza,
   Karina/0000-0002-1810-9018; Pudlo, Robert/0000-0002-5748-0063; Piegza,
   Jacek/0000-0002-7356-4769; Gorczyca, Piotr/0000-0002-9419-7988
CR Albert CM, 2005, CIRCULATION, V111, P480, DOI 10.1161/01.CIR.0000153813.64165.5D
   [Anonymous], 1998, KLAS ZAB PSYCH ZAB Z
   Asbury EA, 2004, EUR HEART J, V25, P1695, DOI 10.1016/j.ehj.2004.07.035
   Barger SD, 2005, J AFFECT DISORDERS, V88, P87, DOI 10.1016/j.jad.2005.05.012
   Bengtson A, 1996, HEART, V75, P257, DOI 10.1136/hrt.75.3.257
   Dudek D, 2007, PSYCHIATR POL, V41, P217
   HAINES AP, 1987, BMJ-BRIT MED J, V295, P297, DOI 10.1136/bmj.295.6593.297
   Heikkilä J, 1999, SCAND J CARING SCI, V13, P3, DOI 10.1080/02839319950162714
   Heikkila J, 1998, J ADV NURS, V28, P54, DOI 10.1046/j.1365-2648.1998.00764.x
   Heikkilä J, 1999, HEART LUNG, V28, P20, DOI 10.1016/S0147-9563(99)70040-3
   KAWACHI I, 1994, CIRCULATION, V89, P1992, DOI 10.1161/01.CIR.89.5.1992
   KAWACHI I, 1994, CIRCULATION, V90, P2225, DOI 10.1161/01.CIR.90.5.2225
   KAWACHI I, 1995, AM J CARDIOL, V75, P882, DOI 10.1016/S0002-9149(99)80680-8
   Mosca L, 1997, CIRCULATION, V96, P2468
   Nikolic G, 2010, VOJNOSANIT PREGL, V67, P530, DOI 10.2298/VSP1007530N
   Pawlak A, 2012, PSYCHIATR POL, V46, P63
   Piegza M, 2004, LEK DEPRESJA, V9, P176
   Piegza M, 2009, ARCH PSYCHIATR PSYCH, V11, P23
   Ruffinengo C, 2009, EUR J CARDIOVASC NUR, V8, P57, DOI 10.1016/j.ejcnurse.2008.04.002
   Rutledge T, 2009, PSYCHOSOM MED, V71, P958, DOI 10.1097/PSY.0b013e3181bd6062
   Sosnowski T., 1983, Przegld Psychologiczny, V2, P393
   Todaro JF, 2003, AM J CARDIOL, V92, P901, DOI 10.1016/S0002-9149(03)00967-6
NR 22
TC 6
Z9 6
U1 0
U2 8
PU VIA MEDICA
PI GDANSK
PA UL SWIETOKRZYSKA 73, 80-180 GDANSK, POLAND
SN 0022-9032
EI 1897-4279
J9 KARDIOL POL
JI Kardiol. Pol.
PY 2014
VL 72
IS 2
BP 175
EP 180
DI 10.5603/KP.a2013.0214
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AC7PB
UT WOS:000332721700010
PM 23990234
OA hybrid
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU van Beers, M
   Janssen, DJA
   Gosker, HR
   Schols, AMWJ
AF van Beers, Martijn
   Janssen, Daisy J. A.
   Gosker, Harry R.
   Schols, Annemie M. W. J.
TI Cognitive impairment in chronic obstructive pulmonary disease: disease
   burden, determinants and possible future interventions
SO EXPERT REVIEW OF RESPIRATORY MEDICINE
LA English
DT Review
DE COPD; cognitive impairment; pathology
ID METABOLIC SYNDROME; SELF-MANAGEMENT; DIETARY PATTERNS; BODY-COMPOSITION;
   COPD PATIENTS; EXECUTIVE FUNCTION; ACUTE EXACERBATION;
   SMOKING-CESSATION; CHRONIC STRESS; OLDER-ADULTS
AB Introduction: Cognitive impairment (CI) is an important but an under-recognized extra-pulmonary feature of chronic obstructive pulmonary disease (COPD). It is related to the burden of disability, worse health outcomes, and impaired self-management. Areas covered: CI includes deterioration of a wide range of cognitive functions, such as memory and various executive functions. Risk of hospitalization might be higher in patients with COPD compared to those without, with CI negatively impacting the wellbeing of patients with COPD. Disease-specific factors such as hypoxemia and inflammation, lifestyle factors such as dietary insufficiencies and lack of physical activity, and comorbidities such as obstructive sleep apnea and depression are likely to synergistically contribute to the development of CI in COPD. Tailored interventions can possibly improve CI in COPD, but this needs further investigation. Expert commentary: Further research is warranted involving the optimization of neuropsychological testing for screening and outcome assessment, longitudinal studies to investigate the development of CI in COPD over time, and randomized clinical trials to test the feasibility and efficacy of promising interventions.
C1 [van Beers, Martijn; Gosker, Harry R.; Schols, Annemie M. W. J.] Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Dept Resp Med, Med Ctr, Maastricht, Netherlands.
   [Janssen, Daisy J. A.] Ctr Expertise Chron Organ Failure, Dept Res & Educ, CIRO, Horn, Netherlands.
   [Janssen, Daisy J. A.] Maastricht Univ, Ctr Expertise Palliat Care, Med Ctr, Maastricht, Netherlands.
C3 Maastricht University; Maastricht University Medical Centre (MUMC);
   Maastricht University
RP van Beers, M (corresponding author), Maastricht Univ, Dept Resp Med, Med Ctr, POB 5800, NL-6202 AZ Maastricht, Netherlands.
EM martijn.vanbeers@maastrichtuniversity.nl
RI Janssen, Daisy/AAW-2248-2021
OI Janssen, Daisy/0000-0002-1827-9869; van Beers,
   Martijn/0000-0001-6193-3160; Gosker, Harry/0000-0002-7659-0225
FU Netherlands Lung Foundation [3.4.09.003]; ZonMW (JPI-HDHL 'Ambrosiac'
   grant)
FX This study was supported by grants from the Netherlands Lung Foundation
   (grant 3.4.09.003) and ZonMW (JPI-HDHL 'Ambrosiac' grant).
CR Abbatecola AM, 2018, CURR OPIN CLIN NUTR, V21, P10, DOI 10.1097/MCO.0000000000000434
   Alexandre F, 2015, MED HYPOTHESES, V84, P25, DOI 10.1016/j.mehy.2014.11.009
   Alfaro FJ, 2016, J NEUROL, V263, P2505, DOI 10.1007/s00415-016-8292-z
   Allen AP, 2017, SOC PERSONAL PSYCHOL, V11, DOI 10.1111/spc3.12309
   Allen SC, 2002, POSTGRAD MED J, V78, P37, DOI 10.1136/pmj.78.915.37
   Andreou Georgia, 2014, Sleep Disord, V2014, P768210, DOI 10.1155/2014/768210
   Andrianopoulos Vasileios, 2017, Breathe (Sheff), V13, pe1, DOI 10.1183/20734735.001417
   [Anonymous], 2017, J AM MED DIR ASSOC, DOI DOI 10.1016/J.JAMDA.2017.01.014
   Antonelli-Incalzi R, 2006, CHEST, V130, P1687, DOI 10.1378/chest.130.6.1687
   Aquino G, 2016, INT J CHRONIC OBSTR, V11, P711, DOI 10.2147/COPD.S96663
   Aras YG, 2017, COGN NEURODYNAMICS, V11, P565, DOI 10.1007/s11571-017-9449-x
   Assuncao N, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194990
   Baird C, 2017, RESP MED, V129, P130, DOI 10.1016/j.rmed.2017.06.006
   Barbey AK, 2013, CORTEX, V49, P1195, DOI 10.1016/j.cortex.2012.05.022
   Barnes PJ, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000220
   Bazinet RP, 2014, NAT REV NEUROSCI, V15, P771, DOI 10.1038/nrn3820
   Belleville S, 2017, NEUROPSYCHOL REV, V27, P328, DOI 10.1007/s11065-017-9361-5
   Benzo RP, 2016, ANN AM THORAC SOC, V13, P10, DOI 10.1513/AnnalsATS.201508-490OC
   Blondell SJ, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-510
   Borson Soo, 2008, Int J Chron Obstruct Pulmon Dis, V3, P429
   Brega AG, 2008, AGE AGEING, V37, P521, DOI 10.1093/ageing/afn121
   Campos Marcela Waisman, 2016, Curr Drug Abuse Rev, V9, P76, DOI 10.2174/1874473709666160803101633
   Cavaillés A, 2013, EUR RESPIR REV, V22, P454, DOI 10.1183/09059180.00008612
   Chang SS, 2012, J AM GERIATR SOC, V60, P1839, DOI 10.1111/j.1532-5415.2012.04171.x
   Chen HT, 2017, J AM GERIATR SOC, V65, P827, DOI 10.1111/jgs.14722
   Chen J, 2016, BRAIN IMAGING BEHAV, V10, P464, DOI 10.1007/s11682-015-9403-7
   Cipriani G, 2012, CLIN GERIATR MED, V20, P3841
   Cleutjens FA, 2016, INT J CHRONIC OBSTR, V12, P1, DOI DOI 10.2147/C0PD.S119633
   Cleutjens FAHM, 2018, CHRON RESP DIS, V15, P91, DOI 10.1177/1479972317709651
   Cleutjens FAHM, 2017, J AM MED DIR ASSOC, V18, P420, DOI 10.1016/j.jamda.2016.11.016
   Cleutjens FAHM, 2017, FRONT AGING NEUROSCI, V9, DOI 10.3389/fnagi.2017.00088
   Cleutjens FAHM, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/697825
   Cohen-Mansfield J, 2016, NICOTINE TOB RES, V18, P1675, DOI 10.1093/ntr/ntw011
   Collins PF, 2018, CLIN NUTR, V37, P144, DOI 10.1016/j.clnu.2016.11.005
   Crisan AF, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0102468
   Dal Negro RW, 2014, INT J CHRONIC OBSTR, V9, P675, DOI 10.2147/COPD.S63485
   Daulatzai Mak Adam, 2012, Sleep Disord, V2012, P251096, DOI 10.1155/2012/251096
   Diamond A, 2013, ANNU REV PSYCHOL, V64, P135, DOI 10.1146/annurev-psych-113011-143750
   Dodd JW, 2010, EUR RESPIR J, V35, P913, DOI 10.1183/09031936.00125109
   Dodd JW, 2015, ANN AM THORAC SOC, V12, P1473, DOI 10.1513/AnnalsATS.201506-373OC
   Dodd JW, 2013, CHEST, V144, P119, DOI 10.1378/chest.12-2099
   Dodd JW, 2012, AM J RESP CRIT CARE, V186, P240, DOI 10.1164/rccm.201202-0355OC
   Dulohery MM, 2015, INT J CHRONIC OBSTR, V10, P1883, DOI 10.2147/COPD.S88035
   Effing TW, 2016, EUR RESPIR J, V48, P46, DOI 10.1183/13993003.00025-2016
   Esser RW, 2016, CHEST, V149, P426, DOI 10.1378/chest.15-0027
   Etnier JL, 2001, MED SCI SPORT EXER, V33, P1620, DOI 10.1097/00005768-200110000-00002
   Falck RS, 2017, BRIT J SPORT MED, V51, P800, DOI 10.1136/bjsports-2015-095551
   Fox AT, 2017, DRUG ALCOHOL DEPEN, V175, P227, DOI 10.1016/j.drugalcdep.2017.01.043
   Fox C, 2011, J AM GERIATR SOC, V59, P1477, DOI 10.1111/j.1532-5415.2011.03491.x
   Fox MD, 2005, P NATL ACAD SCI USA, V102, P9673, DOI 10.1073/pnas.0504136102
   Franz EA, 2011, BRAIN, V134, P3114, DOI 10.1093/brain/awr218
   Fritzsche A, 2013, BRIT J HEALTH PSYCH, V18, P827, DOI 10.1111/bjhp.12025
   GIBSON GE, 1981, AM J MED, V70, P1247, DOI 10.1016/0002-9343(81)90834-2
   Giuli C, 2016, REJUV RES, V19, P485, DOI 10.1089/rej.2015.1791
   GOLD, 2018, GLOBAL STRATEGY DIAG
   GRANT I, 1982, ARCH INTERN MED, V142, P1470, DOI 10.1001/archinte.142.8.1470
   Gray SL, 2015, JAMA INTERN MED, V175, P401, DOI 10.1001/jamainternmed.2014.7663
   Hartmann SE, 2012, EUR RESPIR J, V40, P1354, DOI 10.1183/09031936.00197211
   Heredia Josep Lluis, 2009, Open Respir Med J, V3, P43, DOI 10.2174/1874306400903010043
   Horadagoda C, 2017, INTERN MED J, V47, P1057, DOI 10.1111/imj.13453
   Hu XW, 2018, INT J CHRONIC OBSTR, V13, P519, DOI 10.2147/COPD.S146870
   Incalzi RA, 2003, J NEUROL, V250, P325, DOI 10.1007/s00415-003-1005-4
   Incalzi RA, 2008, REJUV RES, V11, P239, DOI 10.1089/rej.2007.0607
   Jessen F, 2010, EUR ARCH PSY CLIN N, V260, pS111, DOI 10.1007/s00406-010-0156-4
   Joëls M, 2006, TRENDS PHARMACOL SCI, V27, P244, DOI 10.1016/j.tips.2006.03.007
   Jolles J, 1998, Tijdschr Gerontol Geriatr, V29, P120
   Kim YR, 2018, CLINICS, V73, DOI 10.6061/clinics/2018/e177
   Kobayashi Y, 2016, DEMENT GER COGN D EX, V6, P350, DOI 10.1159/000448027
   Kolb B, 2011, INTRO BRAIN BEHAV 3
   Korfias S, 2006, CURR MED CHEM, V13, P3719, DOI 10.2174/092986706779026129
   Lai JS, 2014, AM J CLIN NUTR, V99, P181, DOI 10.3945/ajcn.113.069880
   Leal G, 2015, BRAIN RES, V1621, P82, DOI 10.1016/j.brainres.2014.10.019
   Leung JM, 2016, AM J RESP CRIT CARE, V193, P227, DOI 10.1164/rccm.201510-1977ED
   Lezak M., 2012, NEUROPSYCHOLOGICAL A, V5th edn
   Li J, 2013, RESP RES, V14, DOI 10.1186/1465-9921-14-140
   Ling J, 2016, FRONT PSYCHIATRY, V7, DOI 10.3389/fpsyt.2016.00046
   Lipovec NC, 2016, COPD, V13, P399, DOI 10.3109/15412555.2016.1140732
   Lövblad KO, 2014, SEMIN ULTRASOUND CT, V35, P459, DOI 10.1053/j.sult.2014.06.005
   López-Torres I, 2016, COPD, V13, P327, DOI 10.3109/15412555.2015.1081883
   Marin MF, 2011, NEUROBIOL LEARN MEM, V96, P583, DOI 10.1016/j.nlm.2011.02.016
   Marshall O, 2015, HUM BRAIN MAPP, V36, P3912, DOI 10.1002/hbm.22886
   Martin C R., 2015, Diet and Nutrition in Dementia and Cognitive Decline
   Martinez Carlos H, 2014, Ann Am Thorac Soc, V11, P1362, DOI 10.1513/AnnalsATS.201405-187OC
   Martinez-Lapiscina EH, 2013, J NUTR HEALTH AGING, V17, P544, DOI 10.1007/s12603-013-0027-6
   McEvoy CT, 2017, J AM GERIATR SOC, V65, P1857, DOI 10.1111/jgs.14922
   Meek PM, 2001, EUR RESPIR J, V18, P474, DOI 10.1183/09031936.01.00083501
   Mons U, 2013, EUR J EPIDEMIOL, V28, P823, DOI 10.1007/s10654-013-9840-9
   Morgan AD, 2017, ANN AM THORAC SOC, V14, P754, DOI 10.1513/AnnalsATS.201611-932SR
   Nguyen JCD, 2014, FRONT NEUROSCI-SWITZ, V8, DOI 10.3389/fnins.2014.00375
   Olaithe M, 2018, SLEEP MED REV, V38, P39, DOI 10.1016/j.smrv.2017.03.005
   Ortapamuk H, 2006, ANN NUCL MED, V20, P99, DOI 10.1007/BF02985621
   Ouellette DR, 2017, INT J CHRONIC OBSTR, V12, P639, DOI 10.2147/COPD.S123994
   Overman MJ, 2017, AM J GERIAT PSYCHIAT, V25, P662, DOI 10.1016/j.jagp.2017.02.004
   Ozyemisci-Taskiran O, 2015, CHRON RESP DIS, V12, P247, DOI 10.1177/1479972315589748
   Panza F, 2010, J ALZHEIMERS DIS, V21, P691, DOI 10.3233/JAD-2010-091669
   Park SK, 2018, J CLIN NURS, V27, P1529, DOI 10.1111/jocn.14285
   Pasco JA, 2015, CURR OSTEOPOROS REP, V13, P351, DOI 10.1007/s11914-015-0279-7
   Petersen Ronald C, 2016, Continuum (Minneap Minn), V22, P404, DOI 10.1212/CON.0000000000000313
   Pfistermeister B, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0171353
   Pierobon A, 2017, INT J CHRONIC OBSTR, V12, P2059, DOI 10.2147/COPD.S133586
   Portegies MLP, 2016, AM J RESP CRIT CARE, V193, P251, DOI 10.1164/rccm.201505-0962OC
   Poulose SM, 2017, ADV NUTR, V8, P804, DOI 10.3945/an.117.016261
   Qiao D, 2005, TOXICOL APPL PHARM, V206, P17, DOI 10.1016/j.taap.2004.11.003
   Radley J, 2015, NEUROSCI BIOBEHAV R, V58, P79, DOI 10.1016/j.neubiorev.2015.06.018
   Roebuck-Spencer TM, 2017, ARCH CLIN NEUROPSYCH, V32, P491, DOI 10.1093/arclin/acx021
   Roncero C, 2016, INT J CHRONIC OBSTR, V11, DOI 10.2147/COPD.S100850
   Rusanen M, 2013, CURR ALZHEIMER RES, V10, P549, DOI 10.2174/1567205011310050011
   Ryu CW, 2013, COPD, V10, P357, DOI 10.3109/15412555.2012.752808
   Sachdev PS, 2006, DEMENT GERIATR COGN, V21, P300, DOI 10.1159/000091438
   Samareh Fekri Mitra, 2017, Tanaffos, V16, P34
   Sandi C, 2013, WIRES COGN SCI, V4, P245, DOI 10.1002/wcs.1222
   Schou L, 2012, RESP MED, V106, P1071, DOI 10.1016/j.rmed.2012.03.013
   Schram MT, 2007, J AM GERIATR SOC, V55, P708, DOI 10.1111/j.1532-5415.2007.01159.x
   Schure MB, 2016, RESP MED, V114, P46, DOI 10.1016/j.rmed.2016.03.005
   Shao YK, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0130831
   Sicard KM, 2005, NEUROIMAGE, V25, P850, DOI 10.1016/j.neuroimage.2004.12.010
   Siervo M, 2014, J ALZHEIMERS DIS, V41, P151, DOI 10.3233/JAD-132279
   Smyth A, 2015, NEUROLOGY, V84, P2258, DOI 10.1212/WNL.0000000000001638
   Söderholm M, 2016, EUR J EPIDEMIOL, V31, P159, DOI 10.1007/s10654-015-0113-7
   Solas M, 2017, CURR OPIN PHARMACOL, V37, P87, DOI 10.1016/j.coph.2017.10.005
   Spencer SJ, 2017, NPJ SCI FOOD, V1, DOI 10.1038/s41538-017-0008-y
   Spilling CA, 2017, BMC PULM MED, V17, P1, DOI 10.1186/s12890-017-0435-1
   Sumiyoshi A, 2012, J CEREBR BLOOD F MET, V32, P1853, DOI 10.1038/jcbfm.2012.111
   Swan GE, 2007, NEUROPSYCHOL REV, V17, P259, DOI 10.1007/s11065-007-9035-9
   Szuhany KL, 2015, J PSYCHIATR RES, V60, P56, DOI 10.1016/j.jpsychires.2014.10.003
   Taki Y, 2013, NEURORADIOLOGY, V55, P689, DOI 10.1007/s00234-013-1157-6
   Tangney CC, 2014, NEUROLOGY, V83, P1410, DOI 10.1212/WNL.0000000000000884
   Teppema LJ, 2010, PHYSIOL REV, V90, P675, DOI 10.1152/physrev.00012.2009
   Torres-Sánchez I, 2015, J BRAS PNEUMOL, V41, P182, DOI 10.1590/S1806-37132015000004424
   Tudor-Locke C, 2011, INT J BEHAV NUTR PHY, V8, DOI 10.1186/1479-5868-8-80
   Tulek B, 2014, RESPIROLOGY, V19, P873, DOI 10.1111/resp.12333
   van de Bool C, 2014, EUR J CLIN NUTR, V68, P159, DOI 10.1038/ejcn.2013.257
   Viscogliosi G, 2017, ARCH GERONTOL GERIAT, V70, P62, DOI 10.1016/j.archger.2016.12.008
   Walters JAE, 2018, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD006897.pub4, 10.1002/14651858.C.D006897.pub4]
   Wang CR, 2017, NEUROTOX RES, V31, P453, DOI 10.1007/s12640-016-9690-9
   Wedzicha JA, 2007, LANCET, V370, P786, DOI 10.1016/S0140-6736(07)61382-8
   Wolkowitz OM, 2007, NEUROCASE, V13, P189, DOI 10.1080/13554790701475468
   Yazar EE, 2018, CHRON RESP DIS, V15, P306, DOI 10.1177/1479972317743757
   Yohannes AM, 2016, CHEST, V149, P467, DOI 10.1378/chest.15-0529
   Yu RJ, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027440
   Zhang H, 2013, AM J NEURORADIOL, V34, P334, DOI 10.3174/ajnr.A3235
   Zhang HY, 2012, BMJ OPEN, V2, DOI 10.1136/bmjopen-2012-000844
   Zhang JX, 2016, INT J CHRONIC OBSTR, V11, P1713, DOI 10.2147/COPD.S110089
   Zhang XC, 2011, NEUROIMAGE, V54, P42, DOI 10.1016/j.neuroimage.2010.08.008
   Zhang XC, 2011, NEUROIMAGE, V54, P131, DOI 10.1016/j.neuroimage.2010.07.063
   Zhang XM, 2016, J ALZHEIMERS DIS, V52, P101, DOI 10.3233/JAD-150735
NR 146
TC 33
Z9 34
U1 2
U2 31
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1747-6348
EI 1747-6356
J9 EXPERT REV RESP MED
JI Expert Rev. Respir. Med.
PD DEC 2
PY 2018
VL 12
IS 12
BP 1061
EP 1074
DI 10.1080/17476348.2018.1533405
PG 14
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Respiratory System
GA HC7RP
UT WOS:000451999500009
PM 30296384
OA Green Published
DA 2025-06-11
ER

PT J
AU Balog, M
   Miljanovic, M
   Blazetic, S
   Labak, I
   Ivic, V
   Viljetic, B
   Borbely, A
   Papp, Z
   Blazekovic, R
   Vari, SG
   Fagyas, M
   Heffer, M
AF Balog, Marta
   Miljanovic, Milan
   Blazetic, Senka
   Labak, Irena
   Ivic, Vedrana
   Viljetic, Barbara
   Borbely, Attila
   Papp, Zoltan
   Blazekovic, Robert
   Vari, Sandor G.
   Fagyas, Miklos
   Heffer, Marija
TI Sex-specific chronic stress response at the level of adrenal gland
   modified sexual hormone and leptin receptors
SO CROATIAN MEDICAL JOURNAL
LA English
DT Article
ID PSYCHOSOCIAL STRESS; ANDROGEN RECEPTORS; ESTROGEN-RECEPTORS;
   BODY-WEIGHT; RATS; EXPRESSION; AXIS; IMMUNOREACTIVITY; PROGESTERONE;
   TESTOSTERONE
AB Aim To compare cardiometabolic risk-related biochemical markers and sexual hormone and leptin receptors in the adrenal gland of rat males, non-ovariectomized females (NON-OVX), and ovariectomized females (OVX) under chronic stress.
   Methods Forty six 16-week-old Sprague-Dawley rats were divided into male, NON-OVX, and OVX group and exposed to chronic stress or kept as controls. Weight, glucose tolerance test (GTT), serum concentration of glucose, and cholesterol were measured. Adrenal glands were collected at the age of 28 weeks and immunohistochemical staining against estrogen beta (ER beta), progesterone (PR), testosterone (AR), and leptin (Ob-R) receptors was performed.
   Results Body weight, GTT, serum cholesterol, and glucose changed in response to stress as expected and validated the applied stress protocol. Stressed males had significantly higher number of ER beta receptors in comparison to control group (P = 0.028). Stressed NON-OVX group had significantly decreased AR in comparison to control group (P = 0.007). The levels of PR did not change in any consistent pattern. The levels of Ob-R increased upon stress in all groups, but the significant difference was reached only in the case of stressed OVX group compared to control (P = 0.033).
   Conclusion Chronic stress response was sex specific. OVX females had similar biochemical parameters as males. Changes upon chronic stress in adrenal gland were related to an increase in testosterone receptor in females and decrease in estrogen receptor in males.
C1 [Balog, Marta; Miljanovic, Milan; Ivic, Vedrana; Viljetic, Barbara; Heffer, Marija] JJ Strossmayer Univ Osijek, Fac Med Osijek, Osijek 31000, Croatia.
   [Blazetic, Senka; Labak, Irena] JJ Strossmayer Univ Osijek, Dept Biol Osijek, Osijek 31000, Croatia.
   [Borbely, Attila; Papp, Zoltan; Fagyas, Miklos] Univ Debrecen, Fac Med, Inst Cardiol, Debrecen, Hungary.
   [Blazekovic, Robert] Univ Hosp Dubrava, Dept Cardiac & Transplantat Surg, Zagreb, Croatia.
   [Vari, Sandor G.] Univ Calif Los Angeles, Cedars Sinai Med Ctr, Int Res & Innovat Management Program, Los Angeles, CA 90048 USA.
C3 University of JJ Strossmayer Osijek; University of JJ Strossmayer
   Osijek; University of Debrecen; University of California System;
   University of California Los Angeles; Cedars Sinai Medical Center
RP Heffer, M (corresponding author), JJ Strossmayer Univ Osijek, Fac Med Osijek, Dept Med Biol & Genet, Josipa Huttlera 4, Osijek 31000, Croatia.
EM mheffer@mefos.hr
RI Blažeković, Robert/HGD-3467-2022; Papp, Zoltán/HDO-3347-2022; Viljetic,
   Barbara/MIT-6402-2025; Fagyas, Miklós/AAQ-1013-2020; Ivić,
   Vedrana/GRS-4202-2022; Heffer, Marija/ABA-4694-2020
OI Ivic, Vedrana/0000-0002-8185-1960; Heffer, Marija/0000-0001-6770-7359;
   Vari, MD, Sandor George/0000-0003-2962-2017; Blazekovic,
   Robert/0000-0001-7125-361X
FU J. J. Strossmayer University of Osijek
FX Internal grant from J. J. Strossmayer University of Osijek.
CR Alemán CL, 1998, LAB ANIM, V32, P457, DOI 10.1258/002367798780599802
   Ayala JE, 2010, DIS MODEL MECH, V3, P525, DOI 10.1242/dmm.006239
   Balog M, COLL ANTROP IN PRESS
   Beck-Peccoz P, 2006, ORPHANET J RARE DIS, V1, DOI 10.1186/1750-1172-1-9
   BERGMAN B, 1994, ALCOHOL CLIN EXP RES, V18, P311, DOI 10.1111/j.1530-0277.1994.tb00019.x
   Bruder-Nascimento T, 2013, ARQ BRAS ENDOCRINOL, V57, P642, DOI 10.1590/S0004-27302013000800010
   Brunzell JD, 2008, J AM COLL CARDIOL, V51, P1512, DOI 10.1016/j.jacc.2008.02.034
   Bulun SE., 2011, Williams Textbook of Endocrinology, V12th
   CALANDRA RS, 1978, J STEROID BIOCHEM, V9, P1009, DOI 10.1016/0022-4731(78)90066-3
   Campfield LA, 1996, HORM METAB RES, V28, P619, DOI 10.1055/s-2007-979867
   CHROUSOS GP, 1992, JAMA-J AM MED ASSOC, V267, P1244, DOI 10.1001/jama.267.9.1244
   de Cremoux P, 2008, ENDOCR-RELAT CANCER, V15, P465, DOI 10.1677/ERC-07-0081
   Faraday MM, 2002, PHYSIOL BEHAV, V75, P507, DOI 10.1016/S0031-9384(02)00645-5
   Fowler-Brown AG, 2009, OBESITY, V17, P2106, DOI 10.1038/oby.2009.130
   Friedman JM, 1998, NATURE, V395, P763, DOI 10.1038/27376
   Glasow A, 2000, EUR J CLIN INVEST, V30, P39, DOI 10.1046/j.1365-2362.2000.0300s3039.x
   Glasow A, 1998, J CLIN ENDOCR METAB, V83, P4459, DOI 10.1210/jc.83.12.4459
   Goldstein D.S., 1995, Stress, Catecholamines, and Cardiovascular Disease
   Gréco B, 1998, NEUROENDOCRINOLOGY, V67, P18, DOI 10.1159/000054294
   Harris RBS, 1998, AM J PHYSIOL-REG I, V275, pR1928, DOI 10.1152/ajpregu.1998.275.6.R1928
   HARVEY S, 1984, J EXP ZOOL, V232, P633, DOI 10.1002/jez.1402320332
   Heiman ML, 1997, ENDOCRINOLOGY, V138, P3859, DOI 10.1210/en.138.9.3859
   Heinlein CA, 2002, MOL ENDOCRINOL, V16, P2181, DOI 10.1210/me.2002-0070
   Hermans EJ, 2007, PSYCHONEUROENDOCRINO, V32, P1052, DOI 10.1016/j.psyneuen.2007.08.006
   Jayachandran M, 2002, AM J PHYSIOL-HEART C, V283, pH220, DOI 10.1152/ajpheart.00950.2001
   Jiamsripong Panupong, 2008, Prev Cardiol, V11, P155
   Kirschbaum C, 1996, J CLIN ENDOCR METAB, V81, P3639, DOI 10.1210/jc.81.10.3639
   Kubzansky LD, 2014, JAMA PSYCHIAT, V71, P44, DOI 10.1001/jamapsychiatry.2013.2798
   Kudielka BM, 1999, NEUROENDOCRINOLOGY, V70, P422, DOI 10.1159/000054504
   Kuiper GGJM, 1997, ENDOCRINOLOGY, V138, P863, DOI 10.1210/en.138.3.863
   Larco DO, 2012, ENDOCRINE, V42, P717, DOI 10.1007/s12020-012-9716-x
   Maia DB, 2008, J AFFECT DISORDERS, V107, P259, DOI 10.1016/j.jad.2007.08.013
   Malendowicz LK, 2007, INT REV CYTOL, V263, P63, DOI 10.1016/S0074-7696(07)63002-2
   MARTI O, 1994, PHYSIOL BEHAV, V55, P747, DOI 10.1016/0031-9384(94)90055-8
   Middelbeek R Jan-Willem, 2007, Curr Diab Rep, V7, P43, DOI 10.1007/s11892-007-0008-4
   MUNCK A, 1984, ENDOCR REV, V5, P25, DOI 10.1210/edrv-5-1-25
   Papadimitriou A, 2009, NEUROIMMUNOMODULAT, V16, P265, DOI 10.1159/000216184
   Pirimoglu ZM, 2011, CLIMACTERIC, V14, P453, DOI 10.3109/13697137.2010.539723
   Retana-Márquez S, 2003, HORM BEHAV, V44, P327, DOI 10.1016/j.yhbeh.2003.04.001
   Romeo RD, 2005, STRESS, V8, P265, DOI 10.1080/10253890500489320
   Steptoe A, 2013, ANNU REV PUBL HEALTH, V34, P337, DOI 10.1146/annurev-publhealth-031912-114452
   TAI MM, 1994, DIABETES CARE, V17, P152, DOI 10.2337/diacare.17.2.152
   Tsigos C, 2002, J PSYCHOSOM RES, V53, P865, DOI 10.1016/S0022-3999(02)00429-4
   Vanltallie TB, 2002, METABOLISM, V51, P40, DOI 10.1053/meta.2002.33191
   Von Känel R, 2010, WORLD J BIOL PSYCHIA, V11, P141, DOI 10.3109/15622970903449846
   Wittstein IS, 2005, NEW ENGL J MED, V352, P539, DOI 10.1056/NEJMoa043046
   Zhao H, 2005, REPROD BIOL ENDOCRIN, V3, DOI 10.1186/1477-7827-3-6
NR 47
TC 11
Z9 11
U1 0
U2 19
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-9504
EI 1332-8166
J9 CROAT MED J
JI Croat. Med. J.
PD APR
PY 2015
VL 56
IS 2
BP 104
EP 113
DI 10.3325/cmj.2015.56.104
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CI7LI
UT WOS:000354944500005
PM 25891869
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Liu, FG
   Zhang, X
   Zhao, BT
   Tan, XT
   Wang, LF
   Liu, XB
AF Liu, Fuguo
   Zhang, Xin
   Zhao, Beita
   Tan, Xintong
   Wang, Luanfeng
   Liu, Xuebo
TI Role of Food Phytochemicals in the Modulation of Circadian Clocks
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE phytochemicals; circadian clocks; oxidative stress; inflammation
   response; metabolic disorder
ID METABOLIC SYNDROME; IMPAIRMENT; PATHWAY
AB The circadian clock is an intrinsic mechanism of biological adaptation to the cyclical changes of the environment. The circadian rhythm disorders affect the life activities of organisms. A variety of phytochemicals (e.g., polyphenols, flavonoids, alkaloids, and melatonin) reportedly can regulate the expression and rhythm of circadian clock genes and stabilize the internal environment. This perspective focuses on the relationship of circadian clock genes with oxidative stress, inflammatory response, and metabolic disorders and emphasizes the regulation of phytochemicals on the circadian clock. Potential mechanisms and applications of supplemental phytochemicals to improve metabolic disorders and circadian rhythm disorders are also discussed.
C1 [Liu, Fuguo; Zhang, Xin; Zhao, Beita; Tan, Xintong; Wang, Luanfeng; Liu, Xuebo] Northwest A&F Univ, Coll Food Sci & Engn, Yangling 712100, Shaanxi, Peoples R China.
C3 Northwest A&F University - China
RP Liu, XB (corresponding author), Northwest A&F Univ, Coll Food Sci & Engn, Yangling 712100, Shaanxi, Peoples R China.
EM xueboliu@aliyun.com
RI Zhao, Beita/AAF-7526-2021; ZHANG, XIN/AAQ-2934-2021; LIU,
   Fuguo/U-2396-2019
OI LIU, Fuguo/0000-0002-1645-0976
FU State Key Research and Development Plan "Modern Food Processing and Food
   Storage and Transportation Technology and Equipment" [2017YFD0400200];
   Chinese Universities Scientific Fund [Z109021714]
FX This work was supported by the State Key Research and Development Plan
   "Modern Food Processing and Food Storage and Transportation Technology
   and Equipment" (2017YFD0400200) and Chinese Universities Scientific Fund
   (Z109021714).
CR Adamovich Y, 2014, CELL METAB, V19, P319, DOI 10.1016/j.cmet.2013.12.016
   Bass J, 2016, SCIENCE, V354, P994, DOI 10.1126/science.aah4965
   Burns J, 2002, J AGR FOOD CHEM, V50, P3337, DOI 10.1021/jf0112973
   Dibner C, 2010, ANNU REV PHYSIOL, V72, P517, DOI 10.1146/annurev-physiol-021909-135821
   Gibbs JE, 2012, P NATL ACAD SCI USA, V109, P582, DOI 10.1073/pnas.1106750109
   Guo R, 2018, J AGR FOOD CHEM, V66, P9667, DOI 10.1021/acs.jafc.8b02147
   He BK, 2016, CELL METAB, V23, P610, DOI 10.1016/j.cmet.2016.03.007
   Jacobi D, 2015, CELL METAB, V22, P709, DOI 10.1016/j.cmet.2015.08.006
   Khapre RV, 2011, CELL CYCLE, V10, P4162, DOI 10.4161/cc.10.23.18381
   Kondratov RV, 2009, AGING-US, V1, P979, DOI 10.18632/aging.100113
   Kondratova AA, 2012, NAT REV NEUROSCI, V13, P325, DOI 10.1038/nrn3208
   Mi YS, 2017, BBA-MOL BASIS DIS, V1863, P1575, DOI 10.1016/j.bbadis.2017.04.009
   Narasimamurthy R, 2012, P NATL ACAD SCI USA, V109, P12662, DOI 10.1073/pnas.1209965109
   Orozco-Solis R, 2014, CURR OPIN GENET DEV, V26, P66, DOI 10.1016/j.gde.2014.06.003
   Pan XY, 2010, CELL METAB, V12, P174, DOI 10.1016/j.cmet.2010.05.014
   Panda S, 2019, NAT REV ENDOCRINOL, V15, P67, DOI 10.1038/s41574-018-0142-x
   Park CM, 2011, EUR J PHARMACOL, V660, P454, DOI 10.1016/j.ejphar.2011.04.007
   Paschos GK, 2017, TRENDS GENET, V33, P760, DOI 10.1016/j.tig.2017.07.010
   Pekovic-Vaughan V, 2014, GENE DEV, V28, P548, DOI 10.1101/gad.237081.113
   Qi GY, 2017, J FUNCT FOODS, V34, P168, DOI 10.1016/j.jff.2017.04.031
   Ribas-Latre A, 2015, J NUTR BIOCHEM, V26, P112, DOI 10.1016/j.jnutbio.2014.09.006
   Sanders TH, 2000, J AGR FOOD CHEM, V48, P1243, DOI 10.1021/jf990737b
   Thurley K, 2017, P NATL ACAD SCI USA, V114, P1572, DOI 10.1073/pnas.1613103114
   WELSH DK, 1995, NEURON, V14, P697, DOI 10.1016/0896-6273(95)90214-7
   Xu T, 2019, CRIT REV FOOD SCI, V59, P882, DOI 10.1080/10408398.2018.1493678
   Zwighaft Z, 2015, CELL METAB, V22, P874, DOI 10.1016/j.cmet.2015.09.011
NR 26
TC 41
Z9 43
U1 10
U2 76
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD AUG 14
PY 2019
VL 67
IS 32
BP 8735
EP 8739
DI 10.1021/acs.jafc.9b02263
PG 5
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA IR6QK
UT WOS:000481563600003
PM 31244204
DA 2025-06-11
ER

PT J
AU Lanza, GA
   Parrinello, R
   Figliozzi, S
AF Lanza, Gaetano A.
   Parrinello, Rossella
   Figliozzi, Stefano
TI Management of Microvascular Angina Pectoris
SO AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS
LA English
DT Article
ID CARDIAC SYNDROME-X; NORMAL CORONARY ANGIOGRAMS; SPINAL-CORD STIMULATION;
   CONVERTING ENZYME-INHIBITION; ST-SEGMENT DEPRESSION; TERM-FOLLOW-UP;
   ENHANCED EXTERNAL COUNTERPULSATION; ISCHEMIA SYNDROME EVALUATION;
   EXERCISE-INDUCED ANGINA; CHEST-PAIN
AB Microvascular angina (MVA) is defined as angina pectoris caused by abnormalities of small coronary arteries. In its most typical presentation, MVA is characterized by angina attacks mainly caused by effort, evidence of myocardial ischemia on non-invasive stress tests, but normal coronary arteries at angiography. Patients with stable MVA have excellent long-term prognoses, but often present with persistent and/or worsening of angina symptoms. Treatment of MVA is initially based on standard anti-ischemic drugs (beta-blockers, calcium antagonists, and nitrates), but control of symptoms is often insufficient. In these cases, several additional drugs, with different potential anti-ischemic effects, have been proposed, including ranolazine, ivabradine, angiotensin-converting enzyme (ACE) inhibitors, xanthine derivatives, nicorandil, statins, alpha-blockers and, in perimenopausal women, estrogens. In patients with 'refractory MVA', some further alternative therapies (e.g., spinal cord stimulation, pain-inhibiting substances such as imipramine, rehabilitation programs) have shown favorable results.
C1 [Lanza, Gaetano A.; Parrinello, Rossella; Figliozzi, Stefano] Univ Cattolica Sacro Cuore, Ist Cardiol, Dept Cardiovasc Sci, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Lanza, GA (corresponding author), Univ Cattolica Sacro Cuore, Ist Cardiol, Dept Cardiovasc Sci, Largo A Gemelli 8, I-00168 Rome, Italy.
EM galanza@alice.it
RI Lanza, Gaetano/AAC-2660-2019; Figliozzi, Stefano/AAU-2182-2020
OI Figliozzi, Stefano/0000-0003-2991-1548
CR Al Suwaidi J, 2000, CIRCULATION, V101, P948, DOI 10.1161/01.CIR.101.9.948
   Albertsson PA, 1996, INT J CARDIOL, V54, P13, DOI 10.1016/0167-5273(96)02560-0
   Anderson GL, 2004, JAMA-J AM MED ASSOC, V291, P1701, DOI 10.1001/jama.291.14.1701
   Asbury EA, 2008, MENOPAUSE, V15, P454, DOI 10.1097/gme.0b013e31815982eb
   BASS C, 1984, PSYCHOL MED, V14, P51, DOI 10.1017/S003329170000307X
   Borer JS, 2003, CIRCULATION, V107, P817, DOI 10.1161/01.CIR.0000048143.25023.87
   BUGIARDINI R, 1989, AM J CARDIOL, V63, P286, DOI 10.1016/0002-9149(89)90332-9
   Camici PG, 2007, NEW ENGL J MED, V356, P830, DOI 10.1056/NEJMra061889
   CAMICI PG, 1994, CARDIOVASC DRUG THER, V8, P221, DOI 10.1007/BF00877330
   CANNON RO, 1990, J AM COLL CARDIOL, V16, P1359, DOI 10.1016/0735-1097(90)90377-2
   CANNON RO, 1994, NEW ENGL J MED, V330, P1411, DOI 10.1056/NEJM199405193302003
   CANNON RO, 1985, AM J CARDIOL, V56, P242, DOI 10.1016/0002-9149(85)90842-2
   CHAUHAN A, 1993, BRIT HEART J, V69, P516
   Chauhan A, 1997, EUR HEART J, V18, P60
   Chen JW, 2002, AM J CARDIOL, V90, P974, DOI 10.1016/S0002-9149(02)02664-4
   Chen JW, 1997, AM J CARDIOL, V80, P32
   COLLINS P, 1992, CORONARY ARTERY DIS, V3, P593, DOI 10.1097/00019501-199207000-00008
   Cox ID, 1998, EUR HEART J, V19, P250, DOI 10.1053/euhj.1997.0615
   CREA F, 1990, CIRCULATION, V81, P164, DOI 10.1161/01.CIR.81.1.164
   DEAN JD, 1991, LANCET, V337, P456
   Di Franco A, 2012, IT J PRACTICE CARDIO, V1, P15
   EGASHIRA K, 1993, NEW ENGL J MED, V328, P1659, DOI 10.1056/NEJM199306103282302
   ELIASSON T, 1993, CORONARY ARTERY DIS, V4, P819
   Elliott PM, 1997, HEART, V77, P523, DOI 10.1136/hrt.77.6.523
   EMDIN M, 1989, J AM COLL CARDIOL, V14, P1450, DOI 10.1016/0735-1097(89)90380-X
   Fábián E, 2004, AM J CARDIOL, V94, P652, DOI 10.1016/j.amjcard.2004.05.035
   FERRINI D, 1986, Giornale Italiano di Cardiologia, V16, P224
   Fragasso G, 1997, HEART, V77, P32, DOI 10.1136/hrt.77.1.32
   GALASSI AR, 1989, AM J CARDIOL, V64, P264, DOI 10.1016/0002-9149(89)90517-1
   HARRISON DG, 1993, CIRCULATION, V87, P1461, DOI 10.1161/01.CIR.87.5.1461
   Jhund PS, 2001, J AM COLL CARDIOL, V37, P1367, DOI 10.1016/S0735-1097(01)01168-8
   KASKI JC, 1995, J AM COLL CARDIOL, V25, P807, DOI 10.1016/0735-1097(94)00507-M
   KASKI JC, 1994, J AM COLL CARDIOL, V23, P652, DOI 10.1016/0735-1097(94)90750-1
   Kayikcioglu M, 2003, EUR HEART J, V24, P1999, DOI 10.1016/S0195-668X(03)00478-0
   Keating GM, 2008, DRUGS, V68, P2483, DOI 10.2165/0003495-200868170-00006
   Kitsou V, 2010, ACTA CARDIOL, V65, P239, DOI 10.2143/AC.65.2.2047060
   Kronhaus KD, 2009, INT J CARDIOL, V135, P256, DOI 10.1016/j.ijcard.2008.03.022
   Lamendola P, 2013, ATHEROSCLEROSIS, V226, P157, DOI 10.1016/j.atherosclerosis.2012.10.051
   Lamendola P, 2010, INT J CARDIOL, V140, P197, DOI 10.1016/j.ijcard.2008.11.026
   Lanza G A, 2001, Ital Heart J, V2, P25
   Lanza G A, 1997, G Ital Cardiol, V27, P50
   Lanza GA, 2005, EUR HEART J, V26, P983, DOI 10.1093/eurheartj/ehi089
   Lanza GA, 2004, AM J CARDIOL, V94, P40, DOI 10.1016/j.amjcard.2004.03.027
   Lanza GA, 1997, CIRCULATION, V96, P821
   Lanza GA, 1999, AM J CARDIOL, V84, P1187, DOI 10.1016/S0002-9149(99)00532-9
   Lanza GA, 1999, AM J CARDIOL, V84, P854, DOI 10.1016/S0002-9149(99)00450-6
   Lanza GA, 2007, HEART, V93, P544, DOI 10.1136/hrt.2006.105916
   Lanza GA, 2013, J CARDIOVASC MED, V14, P1, DOI 10.2459/JCM.0b013e328351680f
   Lanza GA, 2010, CIRCULATION, V121, P2317, DOI 10.1161/CIRCULATIONAHA.109.900191
   Leonardo F, 1999, Cardiologia, V44, P1065
   Li L, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038851
   Lindqvist M, 2007, J HYPERTENS, V25, P169, DOI 10.1097/HJH.0b013e3280104dba
   MASERI A, 1991, J AM COLL CARDIOL, V17, P499, DOI 10.1016/S0735-1097(10)80122-6
   Mehta PK, 2011, JACC-CARDIOVASC IMAG, V4, P514, DOI 10.1016/j.jcmg.2011.03.007
   MINAMINO T, 1995, CIRCULATION, V92, P1254, DOI 10.1161/01.CIR.92.5.1254
   MONTORSI P, 1990, AM J CARDIOL, V66, P302, DOI 10.1016/0002-9149(90)90840-W
   MOTZ W, 1991, AM J CARDIOL, V68, P996, DOI 10.1016/0002-9149(91)90485-4
   Nalbantgil, 1999, Int J Angiol, V8, P40, DOI 10.1007/BF01616842
   Nalbantgil I, 1998, CARDIOLOGY, V89, P130, DOI 10.1159/000006768
   Norrsell H, 1997, EUR HEART J, V18, P1890
   Ong P, 2012, CLIN RES CARDIOL, V101, P673, DOI 10.1007/s00392-012-0442-4
   OPHERK D, 1981, CIRCULATION, V63, P817, DOI 10.1161/01.CIR.63.4.817
   Özçelik F, 1999, CLIN CARDIOL, V22, P361
   Pasceri V, 1998, J AM COLL CARDIOL, V31, P62, DOI 10.1016/S0735-1097(97)00421-X
   Patel MR, 2010, NEW ENGL J MED, V363, P498
   Pauly DF, 2011, AM HEART J, V162, P678, DOI 10.1016/j.ahj.2011.07.011
   Pepine CJ, 2010, J AM COLL CARDIOL, V55, P2825, DOI 10.1016/j.jacc.2010.01.054
   PICANO E, 1987, AM J CARDIOL, V60, P508, DOI 10.1016/0002-9149(87)90295-5
   Pizzi C, 2004, CIRCULATION, V109, P53, DOI 10.1161/01.CIR.0000100722.34034.E4
   Potts SG, 1999, QJM-MON J ASSOC PHYS, V92, P81, DOI 10.1093/qjmed/92.2.81
   Radice M, 1996, AM J CARDIOL, V78, P88, DOI 10.1016/S0002-9149(96)00231-7
   ROMEO F, 1988, AM J CARDIOL, V62, P312, DOI 10.1016/0002-9149(88)90232-9
   ROSANO GMC, 1995, EUR HEART J, V16, P610, DOI 10.1093/oxfordjournals.eurheartj.a060963
   Rosano GMC, 1996, J AM COLL CARDIOL, V28, P1500
   Rosen SD, 1999, J CARDIOVASC PHARM, V34, P554, DOI 10.1097/00005344-199910000-00012
   Russo G, 2013, CARDIOVASC DRUG THER, V27, P229, DOI 10.1007/s10557-013-6439-z
   Sestito A, 2011, J CARDIOVASC MED, V12, P322, DOI 10.2459/JCM.0b013e3283406479
   Sgueglia GA, 2007, HEART, V93, P591, DOI 10.1136/hrt.2006.102194
   Sutsch G, 1995, INT J CARDIOL, V52, P135, DOI 10.1016/0167-5273(95)02458-9
   Taylor AJ, 2010, J CARDIOVASC COMPUT, V4, P1, DOI 10.1016/j.jcct.2010.01.010
   Villano A, 2013, AM J CARDIOL, V112, P8, DOI 10.1016/j.amjcard.2013.02.045
   Yamabe H, 1995, CARDIOVASC DRUG THER, V9, P755, DOI 10.1007/BF00879868
   Yoshio H, 1995, J AM COLL CARDIOL, V25, P147
NR 83
TC 28
Z9 35
U1 0
U2 12
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 1175-3277
EI 1179-187X
J9 AM J CARDIOVASC DRUG
JI Am. J. Cardiovasc. Drugs
PD FEB
PY 2014
VL 14
IS 1
BP 31
EP 40
DI 10.1007/s40256-013-0052-1
PG 10
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 302EW
UT WOS:000330585900003
PM 24174173
DA 2025-06-11
ER

PT J
AU Walia, HK
AF Walia, Harneet K.
TI Beyond heart health: Consequences of obstructive sleep apnea
SO CLEVELAND CLINIC JOURNAL OF MEDICINE
LA English
DT Article
ID POSITIVE AIRWAY PRESSURE; DISORDERED BREATHING TREATMENT;
   BLOOD-PRESSURE; METABOLIC SYNDROME; RESISTANT HYPERTENSION;
   ALZHEIMERS-DISEASE; INSULIN-RESISTANCE; OBESE-PATIENTS; WEIGHT-LOSS;
   RISK-FACTOR
AB Obstructive sleep apnea (OSA) is a serious condition associated with impaired quality of life, depression, drowsy driving and motor vehicle accidents, metabolic disease, and cognitive decline. The mechanisms accounting for OSA and metabolic disease include hypoxia, sleep fragmentation, and systemic inflammation. OSA appears to advance cognitive decline, and the relationship between the 2 conditions may be bidirectional. Treatment of patients with continuous positive air pressure therapy improves many of the impaired outcomes associated with OSA. Greater awareness, screening, and treatment of patients with OSA can reduce the negative consequences associated with OSA.
C1 [Walia, Harneet K.] Case Western Reserve Univ, Cleveland Clin Lerner Coll Med, Med, Cleveland, OH 44106 USA.
   [Walia, Harneet K.] Cleveland Clin, Neurol Inst, Sleep Disorders Ctr, S73,9500 Euclid Ave, Cleveland, OH 44195 USA.
C3 University System of Ohio; Case Western Reserve University; Cleveland
   Clinic Foundation; Cleveland Clinic Foundation
RP Walia, HK (corresponding author), Cleveland Clin, Neurol Inst, Sleep Disorders Ctr, S73,9500 Euclid Ave, Cleveland, OH 44195 USA.
EM waliah@ccf.org
CR Arita A, 2015, SLEEP BREATH, V19, P1229, DOI 10.1007/s11325-015-1145-7
   Aurora RN, 2015, J CLIN SLEEP MED, V11, P357, DOI 10.5664/jcsm.4556
   Becker HF, 2003, CIRCULATION, V107, P68, DOI 10.1161/01.CIR.0000042706.47107.7A
   Briançon-Marjollet A, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/s13098-015-0018-3
   Bu XL, 2015, SCI REP-UK, V5, DOI 10.1038/srep13917
   Campos-Rodriguez F, 2006, CHEST, V129, P1459, DOI 10.1378/chest.129.6.1459
   Castronovo V, 2014, SLEEP, V37, P1465, DOI 10.5665/sleep.3994
   Chang TI, 2012, OR SURG OR MED OR PA, V113, P134, DOI 10.1016/j.tripleo.2011.07.039
   Chen HL, 2015, SLEEP, V38, P361, DOI 10.5665/sleep.4490
   Chen YH, 2013, J CLIN SLEEP MED, V9, P417, DOI 10.5664/jcsm.2652
   Chirinos JA, 2014, NEW ENGL J MED, V370, P2265, DOI 10.1056/NEJMoa1306187
   Dorkova Z, 2008, CHEST, V134, P686, DOI 10.1378/chest.08-0556
   Drager LF, 2010, ATHEROSCLEROSIS, V208, P490, DOI 10.1016/j.atherosclerosis.2009.08.016
   Durán-Cantolla J, 2010, BMJ-BRIT MED J, V341, DOI 10.1136/bmj.c5991
   Edwards C, 2015, J CLIN SLEEP MED, V11, P1029, DOI 10.5664/jcsm.5020
   Ejaz Shakir M, 2011, Innov Clin Neurosci, V8, P17
   Farney RJ, 2004, CHEST, V125, P1279, DOI 10.1378/chest.125.4.1279
   Flemons WW, 2002, NEW ENGL J MED, V347, P498, DOI 10.1056/NEJMcp012849
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Foster GD, 2009, ARCH INTERN MED, V169, P1619, DOI 10.1001/archinternmed.2009.266
   Framnes SN, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00440
   Gelber RP, 2015, NEUROLOGY, V84, P296, DOI 10.1212/WNL.0000000000001163
   George CFP, 2001, THORAX, V56, P508, DOI 10.1136/thorax.56.7.508
   Gonçalves SC, 2007, CHEST, V132, P1858, DOI 10.1378/chest.07-1170
   Gottlieb DJ, 2014, NEW ENGL J MED, V370, P2276, DOI 10.1056/NEJMoa1306766
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Harsch IA, 2004, AM J RESP CRIT CARE, V169, P156, DOI 10.1164/rccm.200302-206OC
   Hui DS, 2006, THORAX, V61, P1083, DOI 10.1136/thx.2006.064063
   Iftikhar IH, 2015, J CLIN SLEEP MED, V11, P475, DOI 10.5664/jcsm.4610
   Ju YES, 2014, NAT REV NEUROL, V10, P115, DOI 10.1038/nrneurol.2013.269
   KANIMOZHI S, 2015, J CLIN DIAGN RES, V9, pCC07
   Kim H, 2013, SLEEP, V36, P709, DOI 10.5665/sleep.2632
   Lei Q, 2017, J BRAS PNEUMOL, V43, P373, DOI [10.1590/S1806-37562016000000190, 10.1590/s1806-37562016000000190]
   Lim ASP, 2013, JAMA NEUROL, V70, P1544, DOI 10.1001/jamaneurol.2013.4215
   Lucey BP, 2014, NEUROBIOL AGING, V35, pS29, DOI 10.1016/j.neurobiolaging.2014.03.035
   Marin JM, 2012, JAMA-J AM MED ASSOC, V307, P2169, DOI 10.1001/jama.2012.3418
   Martínez-García MA, 2013, JAMA-J AM MED ASSOC, V310, P2407, DOI 10.1001/jama.2013.281250
   McDaid C, 2009, SLEEP MED REV, V13, P427, DOI 10.1016/j.smrv.2009.02.004
   Montesi SB, 2012, J CLIN SLEEP MED, V8, P587, DOI 10.5664/jcsm.2170
   Mota PC, 2011, SLEEP BREATH, V15, P665, DOI 10.1007/s11325-010-0417-5
   Nakanishi-Minami T, 2012, DIABETOL METAB SYNDR, V4, DOI 10.1186/1758-5996-4-6
   NHTSA, 2011, DROWSY DRIV
   Nieto F Javier, 2009, WMJ, V108, P263
   Nieto FJ, 2000, JAMA-J AM MED ASSOC, V283, P1829, DOI 10.1001/jama.283.14.1829
   Nock NL, 2009, SLEEP, V32, P615, DOI 10.1093/sleep/32.5.615
   Oktay B, 2009, ACTA CLIN BELG, V64, P329, DOI 10.1179/acb.2009.051
   Osorio RS, 2015, NEUROLOGY, V84, P1964, DOI 10.1212/WNL.0000000000001566
   Pépin JL, 2012, THORAX, V67, P1025, DOI 10.1136/thoraxjnl-2012-202807
   Peppard PE, 2006, ARCH INTERN MED, V166, P1709, DOI 10.1001/archinte.166.16.1709
   Peppard PE, 2000, NEW ENGL J MED, V342, P1378, DOI 10.1056/NEJM200005113421901
   Pepperell JCT, 2002, LANCET, V359, P204, DOI 10.1016/S0140-6736(02)07445-7
   Polsek D, 2018, NEUROSCI BIOBEHAV R, V86, P142, DOI 10.1016/j.neubiorev.2017.12.004
   Relia S, 2018, SLEEP BREATH, V22, P195, DOI 10.1007/s11325-018-1626-6
   Robinson GV, 2006, EUR RESPIR J, V27, P1229, DOI 10.1183/09031936.06.00062805
   Sadasivam K, 2015, J CLIN DIAGN RES, V9, pCC7, DOI 10.7860/JCDR/2015/13301.5859
   Sateia MJ, 2014, CHEST, V146, P1387, DOI 10.1378/chest.14-0970
   Spiegel K, 2005, J APPL PHYSIOL, V99, P2008, DOI 10.1152/japplphysiol.00660.2005
   Stamatakis KA, 2010, CHEST, V137, P95, DOI 10.1378/chest.09-0791
   Terán-Santos J, 1999, NEW ENGL J MED, V340, P847, DOI 10.1056/NEJM199903183401104
   Trenell MI, 2007, DIABETES OBES METAB, V9, P679, DOI 10.1111/j.1463-1326.2006.00649.x
   Usui Y, 2012, SLEEP BREATH, V16, P677, DOI 10.1007/s11325-011-0557-2
   Vakulin A, 2016, CLIN NEUROPHYSIOL, V127, P1428, DOI 10.1016/j.clinph.2015.09.004
   Walia HK, 2017, J CLIN SLEEP MED, V13, P1255, DOI 10.5664/jcsm.6792
   Walia HK, 2016, CHEST, V149, P747, DOI 10.1378/chest.15-0697
   Walia HK, 2014, J CLIN SLEEP MED, V10, P835, DOI 10.5664/jcsm.3946
   Walia HK, J CLIN SLEEP MED
   Xie LL, 2013, SCIENCE, V342, P373, DOI 10.1126/science.1241224
   Xu SY, 2015, BMC PULM MED, V15, DOI 10.1186/s12890-015-0102-3
   Yaffe K, 2011, JAMA-J AM MED ASSOC, V306, P613, DOI 10.1001/jama.2011.1115
   Young T, 1997, SLEEP, V20, P608, DOI 10.1093/sleep/20.8.608
   Young T, 2002, AM J RESP CRIT CARE, V165, P1217, DOI 10.1164/rccm.2109080
   Zhu BQ, 2018, SLEEP BREATH, V22, P287, DOI 10.1007/s11325-017-1554-x
NR 72
TC 10
Z9 11
U1 0
U2 4
PU CLEVELAND CLINIC
PI CLEVELAND
PA 9500 EUCLID AVE, CLEVELAND, OH 44106 USA
SN 0891-1150
EI 1939-2869
J9 CLEV CLIN J MED
JI Clevel. Clin. J. Med.
PD SEP
PY 2019
VL 86
SU 1
BP 19
EP 25
DI 10.3949/ccjm.86.s1.04
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IY5VS
UT WOS:000486462800004
PM 31509500
OA gold
DA 2025-06-11
ER

PT J
AU Ziberna, L
   Jenko-Praznikar, Z
   Petelin, A
AF Ziberna, Lovro
   Jenko-Praznikar, Zala
   Petelin, Ana
TI Serum Bilirubin Levels in Overweight and Obese Individuals: The
   Importance of Anti-Inflammatory and Antioxidant Responses
SO ANTIOXIDANTS
LA English
DT Review
DE adipokines; antioxidant; anti-inflammatory; bilirubin; obesity;
   overweight
ID NECROSIS-FACTOR-ALPHA; CONSTITUTIVE ANDROSTANE RECEPTOR;
   PROLIFERATOR-ACTIVATED RECEPTOR; IMPROVES INSULIN SENSITIVITY; HUMAN
   FAT-CELLS; ADIPOSE-TISSUE; OXIDATIVE STRESS; METABOLIC SYNDROME; HEME
   OXYGENASE; CHRONIC INFLAMMATION
AB Obesity is a chronic condition involving low-grade inflammation and increased oxidative stress; thus, obese and overweight people have lower values of serum bilirubin. Essentially, bilirubin is a potent endogenous antioxidant molecule with anti-inflammatory, immunomodulatory, antithrombotic, and endocrine properties. This review paper presents the interplay between obesity-related pathological processes and bilirubin, with a focus on adipose tissue and adipokines. We discuss potential strategies to mildly increase serum bilirubin levels in obese patients as an adjunctive therapeutic approach.
C1 [Ziberna, Lovro] Univ Ljubljana, Fac Med, Inst Pharmacol & Expt Toxicol, SI-1000 Ljubljana, Slovenia.
   [Jenko-Praznikar, Zala; Petelin, Ana] Univ Primorska, Fac Hlth Sci, SI-6310 Izola, Slovenia.
C3 University of Ljubljana; University of Primorska
RP Petelin, A (corresponding author), Univ Primorska, Fac Hlth Sci, SI-6310 Izola, Slovenia.
EM lovro.ziberna@mf.uni-lj.si; zala.praznikar@upr.si; ana.petelin@upr.si
RI Ziberna, Lovro/A-1107-2010; Petelin, Ana/GLV-1610-2022; Jenko Praznikar,
   Zala/KVX-9901-2024
OI Ziberna, Lovro/0000-0002-2840-5208; Petelin, Ana/0000-0002-5557-5974;
   Jenko Praznikar, Zala/0000-0002-5217-8754
FU Slovenian Research Agency [J3 8209, P1 0386, P3 0067]; University of
   Primorska, Faculty of Health Sciences
FX The authors acknowledge that this work was financially supported by the
   Slovenian Research Agency under research project J3 8209 (Bilirubin as a
   Protective Factor Against Chronic Degenerative Disease: Biomarker and
   Potential for Pharmacological Modulation) and research programs P1 0386
   and P3 0067. Additionally, we were financially supported by the
   University of Primorska, Faculty of Health Sciences, for the project
   entitled A Multidisciplinary Approach in the Treatment of Obesity.
CR Ahima RS, 2000, ANNU REV PHYSIOL, V62, P413, DOI 10.1146/annurev.physiol.62.1.413
   Andersson C, 2009, METABOLISM, V58, P1109, DOI 10.1016/j.metabol.2009.04.003
   BAIRD IM, 1981, INT J OBESITY, V5, P249
   Bellarosa C, 2021, J CLIN MED, V10, DOI 10.3390/jcm10132812
   Belo L, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0098467
   BREIMER LH, 1995, CLIN CHEM, V41, P1504
   Burgess A, 2010, HYPERTENSION, V56, P1124, DOI 10.1161/HYPERTENSIONAHA.110.151423
   Calder PC, 2011, BRIT J NUTR, V106, pS1, DOI 10.1017/S0007114511005460
   Castoldi A, 2016, FRONT IMMUNOL, V6, DOI 10.3389/fimmu.2015.00637
   Chen H, 2003, J BIOL CHEM, V278, P45021, DOI 10.1074/jbc.M307878200
   Crane HM, 2019, JAIDS-J ACQ IMM DEF, V81, pE141, DOI 10.1097/QAI.0000000000002071
   Creeden JF, 2021, AM J PHYSIOL-ENDOC M, V320, pE191, DOI 10.1152/ajpendo.00405.2020
   Curat CA, 2006, DIABETOLOGIA, V49, P744, DOI 10.1007/s00125-006-0173-z
   D'Andrea V, 2005, LIFE SCI, V77, P683, DOI 10.1016/j.lfs.2005.01.011
   De Marchi E, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/564961
   Dekker D, 2011, ARTERIOSCL THROM VAS, V31, P458, DOI 10.1161/ATVBAHA.110.211789
   Den Hartigh LJ, 2017, ARTERIOSCL THROM VAS, V37, P466, DOI 10.1161/ATVBAHA.116.308749
   Dias S, 2018, INT J ENDOCRINOL, V2018, DOI 10.1155/2018/2637418
   Dietze-Schroeder D, 2005, DIABETES, V54, P2003, DOI 10.2337/diabetes.54.7.2003
   DiNicolantonio JJ, 2018, OPEN HEART, V5, DOI 10.1136/openhrt-2018-000914
   Dludla PV, 2018, PHARMACOL RES, V137, P11, DOI 10.1016/j.phrs.2018.09.013
   Dludla PV, 2017, NUTR METAB, V14, DOI 10.1186/s12986-017-0200-8
   Dong HS, 2014, ENDOCRINOLOGY, V155, P818, DOI 10.1210/en.2013-1667
   Ebrahimi M, 2016, J CLIN LAB ANAL, V30, P672, DOI 10.1002/jcla.21920
   El-Eshmawy MM, 2022, ENDOCR METAB IMMUNE, V22, P64, DOI 10.2174/1871530321999210128201259
   Ellulu MS, 2016, INT J CARDIOL, V215, P318, DOI 10.1016/j.ijcard.2016.04.089
   Eremiasova L, 2020, CIRC J, V84, P1779, DOI 10.1253/circj.CJ-20-0192
   Fasshauer M, 2015, TRENDS PHARMACOL SCI, V36, P461, DOI 10.1016/j.tips.2015.04.014
   Feder S, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20163919
   Ferrándiz ML, 2008, CURR PHARM DESIGN, V14, P473, DOI 10.2174/138161208783597399
   Figge A, 2021, CLIN NUTR, V40, P2609, DOI 10.1016/j.clnu.2021.04.008
   FRIIS R, 1987, J CLIN GASTROENTEROL, V9, P204, DOI 10.1097/00004836-198704000-00019
   Fulks Michael, 2009, J Insur Med, V41, P49
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Galic S, 2010, MOL CELL ENDOCRINOL, V316, P129, DOI 10.1016/j.mce.2009.08.018
   Gao J, 2009, J BIOL CHEM, V284, P25984, DOI 10.1074/jbc.M109.016808
   Gordon DM, 2020, J BIOL CHEM, V295, P9804, DOI 10.1074/jbc.RA120.013700
   Gordon DM, 2019, PHYSIOL GENOMICS, V51, P234, DOI 10.1152/physiolgenomics.00028.2019
   Gross B, 2017, NAT REV ENDOCRINOL, V13, P36, DOI 10.1038/nrendo.2016.135
   Han CY, 2016, DIABETES METAB J, V40, P272
   Han CY, 2012, J BIOL CHEM, V287, P10379, DOI 10.1074/jbc.M111.304998
   Hinds TD, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.594574
   Hinds TD, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9090889
   Hinds TD, 2017, AM J PHYSIOL-ENDOC M, V312, pE291, DOI 10.1152/ajpendo.00396.2016
   Hinds TD, 2016, J BIOL CHEM, V291, P25179, DOI 10.1074/jbc.M116.731703
   Hosick PA, 2012, AM J PHYSIOL-REG I, V302, pR207, DOI 10.1152/ajpregu.00517.2011
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   HOWARD AN, 1978, INT J OBESITY, V2, P321
   Huang WD, 2003, P NATL ACAD SCI USA, V100, P4156, DOI 10.1073/pnas.0630614100
   Hurrle S, 2017, BIOMED J, V40, P257, DOI 10.1016/j.bj.2017.06.007
   Ikeda N, 2011, DIABETOLOGIA, V54, P2183, DOI 10.1007/s00125-011-2197-2
   Inoguchi T, 2016, DIABETOL INT, V7, P338, DOI 10.1007/s13340-016-0288-5
   Inoue Y, 2018, NEUROCHEM INT, V112, P288, DOI 10.1016/j.neuint.2017.08.011
   Intagliata S, 2019, EUR J MED CHEM, V183, DOI 10.1016/j.ejmech.2019.111703
   Jangi S, 2013, INT J BIOCHEM CELL B, V45, P2843, DOI 10.1016/j.biocel.2013.09.014
   Jankovic A, 2015, REDOX BIOL, V6, P19, DOI 10.1016/j.redox.2015.06.018
   Jansen T, 2012, FRONT PHARMACOL, V3, DOI 10.3389/fphar.2012.00030
   Jenko-Praznikar Z, 2013, METABOLISM, V62, P976, DOI 10.1016/j.metabol.2013.01.011
   Jette M, 1975, J Sports Med, V3, P12
   Kang YE, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0154003
   Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2548, DOI 10.1210/jc.2004-0395
   Kersten S, 2014, MOL METAB, V3, P354, DOI 10.1016/j.molmet.2014.02.002
   Kim DH, 2008, J PHARMACOL EXP THER, V325, P833, DOI 10.1124/jpet.107.135285
   Kim DH, 2010, STEM CELLS DEV, V19, P1863, DOI 10.1089/scd.2010.0098
   Konícková R, 2014, ANN HEPATOL, V13, P273, DOI 10.1016/S1665-2681(19)30891-9
   Kratz M, 2014, CELL METAB, V20, P614, DOI 10.1016/j.cmet.2014.08.010
   Kunutsor SK, 2015, EXP GERONTOL, V72, P63, DOI 10.1016/j.exger.2015.09.014
   Lanone S, 2005, FASEB J, V19, P1890, DOI 10.1096/fj.04-2368fje
   Li M, 2008, DIABETES, V57, P1526, DOI 10.2337/db07-1764
   Lippi G, 2009, LIVER INT, V29, P315, DOI 10.1111/j.1478-3231.2008.01821.x
   Liu JF, 2015, SCI REP-UK, V5, DOI 10.1038/srep09886
   Liu YR, 2008, J IMMUNOL, V181, P1887, DOI 10.4049/jimmunol.181.3.1887
   Loprinzi PD, 2015, ANGIOLOGY, V66, P286, DOI 10.1177/0003319714537111
   Loprinzi PD, 2014, J DIABETES METAB DIS, V13, DOI 10.1186/2251-6581-13-47
   Lozano R, 2013, CLIN PHARMACOL-ADV A, V5, P153, DOI 10.2147/CPAA.S48377
   Lumeng CN, 2007, J CLIN INVEST, V117, P175, DOI 10.1172/JCI29881
   Lumeng CN, 2011, J CLIN INVEST, V121, P2111, DOI 10.1172/JCI57132
   Mantovani A, 2013, J PATHOL, V229, P176, DOI 10.1002/path.4133
   McArdle Maeve A, 2013, Front Endocrinol (Lausanne), V4, P52, DOI 10.3389/fendo.2013.00052
   McCallum L, 2015, HYPERTENSION, V66, P37, DOI 10.1161/HYPERTENSIONAHA.114.04915
   Melissas J, 2006, OBES SURG, V16, P314, DOI 10.1381/096089206776116444
   Misan A, 2017, J FUNCT FOODS, V36, P186, DOI 10.1016/j.jff.2017.06.056
   Mohamed MEF, 2011, PLANTA MED, V77, P311, DOI 10.1055/s-0030-1250457
   Mohamed-Ali V, 1997, J CLIN ENDOCR METAB, V82, P4196, DOI 10.1210/jc.82.12.4196
   Muchova L, 2007, CAN J PHYSIOL PHARM, V85, P800, DOI 10.1139/Y07-077
   Murphy MP, 2009, BIOCHEM J, V417, P1, DOI 10.1042/BJ20081386
   Nakamura K, 2014, J CARDIOL, V63, P250, DOI 10.1016/j.jjcc.2013.11.006
   Nano J, 2016, DIABETES METAB, V42, P389, DOI 10.1016/j.diabet.2016.06.002
   Nascimento H, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/1758-5996-7-4
   Nicolai A, 2009, HYPERTENSION, V53, P508, DOI 10.1161/HYPERTENSIONAHA.108.124701
   Ohnaka K, 2010, DIABETES RES CLIN PR, V88, P103, DOI 10.1016/j.diabres.2009.12.022
   Pallister T, 2017, INT J OBESITY, V41, P1106, DOI 10.1038/ijo.2017.70
   Panee J, 2012, CYTOKINE, V60, P1, DOI 10.1016/j.cyto.2012.06.018
   Perlstein TS, 2008, ARTERIOSCL THROM VAS, V28, P166, DOI 10.1161/ATVBAHA.107.153262
   Petelin A, 2020, ACTA CLIN CROAT, V59, P19, DOI 10.20471/acc.2020.59.01.03
   Petelin A, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/4969720
   Pittalà V, 2017, CURR PHARM DESIGN, V23, P2657, DOI 10.2174/1381612823666170210151411
   ROBERTSON A, 1991, DEV PHARMACOL THERAP, V17, P95, DOI 10.1159/000457504
   Rotter V, 2003, J BIOL CHEM, V278, P45777, DOI 10.1074/jbc.M301977200
   Ruan H, 2002, DIABETES, V51, P3176, DOI 10.2337/diabetes.51.11.3176
   Saracino MR, 2009, J NUTR, V139, P555, DOI 10.3945/jn.108.097279
   Senn JJ, 2003, J BIOL CHEM, V278, P13740, DOI 10.1074/jbc.M210689200
   Sies H, 2015, REDOX BIOL, V4, P180, DOI 10.1016/j.redox.2015.01.002
   Skrypnik D, 2016, BIOMED PHARMACOTHER, V80, P1, DOI 10.1016/j.biopha.2016.02.017
   Soligard HT, 2010, PEDIATR RES, V67, P614, DOI 10.1203/PDR.0b013e3181da7578
   Sonoli SS, 2011, EUR REV MED PHARMACO, V15, P9
   Stec DE, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0153427
   Stephens JM, 1997, J BIOL CHEM, V272, P971, DOI 10.1074/jbc.272.2.971
   STOCKER R, 1987, SCIENCE, V235, P1043, DOI 10.1126/science.3029864
   Suk J, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/6026902
   Swift DL, 2012, MED SCI SPORT EXER, V44, P569, DOI 10.1249/MSS.0b013e3182357dd4
   Takei R, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0223302
   Talior I, 2005, AM J PHYSIOL-ENDOC M, V288, pE405, DOI 10.1152/ajpendo.00378.2004
   Tyagi S, 2011, J ADV PHARM TECHNOL, V2, P236, DOI 10.4103/2231-4040.90879
   Vítek L, 2021, J HEPATOL, V75, P1485, DOI 10.1016/j.jhep.2021.06.010
   Vítek L, 2020, MED RES REV, V40, P1335, DOI 10.1002/med.21660
   Vitek L, 2019, ARCH BIOCHEM BIOPHYS, V672, DOI 10.1016/j.abb.2019.108062
   Vitek L, 2019, CLIN PHARMACOL THER, V106, P568, DOI 10.1002/cpt.1341
   Vítek L, 2012, FRONT PHARMACOL, V3, DOI 10.3389/fphar.2012.00055
   Volanakis JE, 2001, MOL IMMUNOL, V38, P189, DOI 10.1016/S0161-5890(01)00042-6
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Witek K, 2017, BIOL SPORT, V34, P45, DOI 10.5114/biolsport.2017.63732
   Xiao L, 2010, ADV DRUG DELIVER REV, V62, P1316, DOI 10.1016/j.addr.2010.07.006
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Xu J, 2014, J KOREAN MED SCI, V29, pS155, DOI 10.3346/jkms.2014.29.S2.S155
   Yamauchi T, 2002, NAT MED, V8, P1288, DOI 10.1038/nm788
   Yan J, 2015, ACTA PHARMACOL SIN, V36, P62, DOI 10.1038/aps.2014.102
   Yang H, 2014, PROTEIN CELL, V5, P113, DOI 10.1007/s13238-013-0013-0
   Yoshino S, 2011, J ATHEROSCLER THROMB, V18, P403, DOI 10.5551/jat.6346
   Zhu HQ, 2010, EXP MOL MED, V42, P739, DOI 10.3858/emm.2010.42.11.075
   Ziberna L, 2016, SCI REP-UK, V6, DOI 10.1038/srep29240
   Zuperl S, 2011, ANAL CHIM ACTA, V705, P322, DOI 10.1016/j.aca.2011.07.004
NR 132
TC 30
Z9 30
U1 1
U2 21
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD SEP
PY 2021
VL 10
IS 9
AR 1352
DI 10.3390/antiox10091352
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA UV2PM
UT WOS:000699327300001
PM 34572984
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hadziabdic, MO
   Bozikov, V
   Pavic, E
   Romic, Z
AF Hadziabdic, Maja Ortner
   Bozikov, Velimir
   Pavic, Eva
   Romic, Zeljko
TI The Antioxidative Protecting Role of the Mediterranean Diet
SO COLLEGIUM ANTROPOLOGICUM
LA English
DT Article
DE Mediterranean diet (MD); oxidative stress (OS); antioxidative property;
   oxidative stress biomarkers
ID CORONARY-HEART-DISEASE; DENSITY-LIPOPROTEIN OXIDATION; VIRGIN OLIVE OIL;
   ENDOTHELIAL FUNCTION; PHENOLIC-COMPOUNDS; RISK-FACTORS; METABOLIC
   SYNDROME; DNA-DAMAGE; STRESS; CAPACITY
AB Recent meta-analysis shows that adherence to a Mediterranean diet (MD) can significantly decrease the risk of overall mortality, mortality from cardiovascular diseases, as well as incidence of mortality from cancer, and incidence of Parkinson's and Alzheimer's disease. All of these diseases could be linked to oxidative stress (OS) as antioxidative effect of MD is getting more attention nowadays. Although a lot of research has been done in this area and it suggests antioxidative protective role of MD, the presented evidence is still inconclusive. The aim of this paper is to review studies investigating the effect of MD on OS, as well as to identify the areas for further research.
C1 [Hadziabdic, Maja Ortner] Univ Zagreb, Fac Pharm & Biochem, Ctr Appl Pharm, Zagreb 10000, Croatia.
   [Bozikov, Velimir] Univ Zagreb, Dubrava Univ Hosp, Dept Endocrinol Diabet & Metab Disorders, Zagreb 10000, Croatia.
   [Pavic, Eva] Univ Zagreb, Zagreb Univ Hosp Ctr, Dept Nutr, Zagreb 10000, Croatia.
   [Romic, Zeljko] Univ Zagreb, Dubrava Univ Hosp, Clin Dept Lab Diagnost, Zagreb 10000, Croatia.
C3 University of Zagreb; University of Zagreb; University of Zagreb;
   UNIVERSITY ZAGREB HOSPITAL; University of Zagreb
RP Hadziabdic, MO (corresponding author), Univ Zagreb, Fac Pharm & Biochem, Ctr Appl Pharm, Ante Kovacica 1, Zagreb 10000, Croatia.
EM mortner@pharma.hr
CR Ambring A, 2004, CLIN SCI, V106, P519, DOI 10.1042/CS20030315
   Andersen JK, 2004, NAT MED, V10, pS18, DOI 10.1038/nrn1434
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Buscemi S, 2009, EUR J CLIN INVEST, V39, P339, DOI 10.1111/j.1365-2362.2009.02091.x
   Cao GH, 1998, CLIN CHEM, V44, P1309
   Carevic V, 2010, COLLEGIUM ANTROPOL, V34, P1363
   Cordova AC, 2012, J AM COLL SURGEONS, V214, P97, DOI 10.1016/j.jamcollsurg.2011.09.023
   Dai J, 2008, AM J CLIN NUTR, V88, P1364, DOI 10.3945/ajcn.2008.26528
   Das S, 2000, CURR SCI INDIA, V79, P1665
   Demarin V, 2011, ACTA CLIN CROAT, V50, P67
   Esterbauer Hermann, 1993, Current Opinion in Lipidology, V4, P114, DOI 10.1097/00041433-199304000-00007
   Fitó M, 2000, LIPIDS, V35, P633, DOI 10.1007/s11745-000-0567-1
   Fitó M, 2007, ARCH INTERN MED, V167, P1195, DOI 10.1001/archinte.167.11.1195
   Fraley AE, 2006, CURR OPIN LIPIDOL, V17, P502, DOI 10.1097/01.mol.0000245255.40634.b5
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Ghiselli A, 1997, EUR J CANCER PREV, V6, pS15, DOI 10.1097/00008469-199703001-00004
   GR DI, 2009, AM J CLIN NUTR, V89, P354, DOI 10.394/ajen.2008.26661
   Hagfors L, 2003, NUTR J, V2, DOI 10.1186/1475-2891-2-5
   Halliwell B, 2007, BIOCHEM J, V401, P1, DOI 10.1042/BJ20061131
   Harma MI, 2006, EUR J OBSTET GYN R B, V127, P271, DOI 10.1016/j.ejogrb.2006.01.037
   Jones DP, 2002, METHOD ENZYMOL, V348, P93, DOI 10.1016/S0076-6879(02)48630-2
   Kastorini CM, 2011, J AM COLL CARDIOL, V57, P1299, DOI 10.1016/j.jacc.2010.09.073
   KEYS A, 1984, PREV MED, V13, P141, DOI 10.1016/0091-7435(84)90047-1
   Keys A, 1966, Acta Med Scand Suppl, V460, P1
   KEYS A, 1957, AM J PUBLIC HEALTH N, V47, P1520, DOI 10.2105/AJPH.47.12.1520
   Leighton F, 1999, DRUG EXP CLIN RES, V25, P133
   López-Uriarte P, 2010, CLIN NUTR, V29, P373, DOI 10.1016/j.clnu.2009.12.008
   Lorgis L, 2010, ATHEROSCLEROSIS, V213, P616, DOI 10.1016/j.atherosclerosis.2010.09.018
   Maddux BA, 2001, DIABETES, V50, P404, DOI 10.2337/diabetes.50.2.404
   Maritim AC, 2003, J BIOCHEM MOL TOXIC, V17, P24, DOI 10.1002/jbt.10058
   Matsuoka T, 1997, J CLIN INVEST, V99, P144, DOI 10.1172/JCI119126
   Murie-Fernandez M, 2011, ATHEROSCLEROSIS, V219, P158, DOI 10.1016/j.atherosclerosis.2011.06.050
   Nadtochiy SM, 2011, NUTRITION, V27, P733, DOI 10.1016/j.nut.2010.12.006
   NAKAZONO K, 1991, P NATL ACAD SCI USA, V88, P10045, DOI 10.1073/pnas.88.22.10045
   Nourooz-Zadeh J, 2005, BIOCHEM BIOPH RES CO, V330, P731, DOI 10.1016/j.bbrc.2005.03.024
   Nyska A, 2002, TOXICOL PATHOL, V30, P620, DOI 10.1080/01926230290166724
   OHARA Y, 1993, J CLIN INVEST, V91, P2546, DOI 10.1172/JCI116491
   Owen RW, 2000, FOOD CHEM TOXICOL, V38, P647, DOI 10.1016/S0278-6915(00)00061-2
   Palmieri B, 2007, EUR REV MED PHARMACO, V11, P309
   Pérez-López FR, 2009, MATURITAS, V64, P67, DOI 10.1016/j.maturitas.2009.07.013
   Petlevski R, 2009, COLLEGIUM ANTROPOL, V33, P1251
   Pitsavos C, 2005, AM J CLIN NUTR, V82, P694, DOI 10.1093/ajcn/82.3.694
   Prior RL, 1999, FREE RADICAL BIO MED, V27, P1173, DOI 10.1016/S0891-5849(99)00203-8
   Prior Ronald L., 2004, Journal of Nutrition, V134, p3184S
   Razquin C, 2009, EUR J CLIN NUTR, V63, P1387, DOI 10.1038/ejcn.2009.106
   Rudich A, 1998, DIABETES, V47, P1562, DOI 10.2337/diabetes.47.10.1562
   Sánchez-Moreno C, 2006, J NUTR BIOCHEM, V17, P183, DOI 10.1016/j.jnutbio.2005.07.001
   Simonian NA, 1996, ANNU REV PHARMACOL, V36, P83, DOI 10.1146/annurev.pa.36.040196.000503
   Singh Uma, 2006, Pathophysiology, V13, P129, DOI 10.1016/j.pathophys.2006.05.002
   Sofi F, 2008, BMJ-BRIT MED J, V337, DOI 10.1136/bmj.a1344
   Stachowska E, 2005, BRIT J NUTR, V93, P345, DOI 10.1079/BJN20051374
   Steinkellner H, 2001, MUTAT RES-FUND MOL M, V480, P285, DOI 10.1016/S0027-5107(01)00188-9
   Steinmetz KA, 1996, J AM DIET ASSOC, V96, P1027, DOI 10.1016/S0002-8223(96)00273-8
   Sutherland JC, 2001, ELECTROPHORESIS, V22, P843, DOI 10.1002/1522-2683()22:5<843::AID-ELPS843>3.0.CO;2-9
   TREVISAN M, 1990, JAMA-J AM MED ASSOC, V263, P688, DOI 10.1001/jama.263.5.688
   TRICHOPOULOU A, 1995, JNCI-J NATL CANCER I, V87, P110, DOI 10.1093/jnci/87.2.110
   Trichopoulou A, 2007, MOL NUTR FOOD RES, V51, P1275, DOI 10.1002/mnfr.200700134
   Urpi-Sarda M, 2012, PHARMACOL RES, V65, P577, DOI 10.1016/j.phrs.2012.03.006
   Urquiaga I, 2010, ATHEROSCLEROSIS, V211, P694, DOI 10.1016/j.atherosclerosis.2010.04.020
   Vassalle C, 2004, J INTERN MED, V256, P308, DOI 10.1111/j.1365-2796.2004.01373.x
   Visioli F, 2000, CIRCULATION, V102, P2169
   VISIOLI F, 1995, ATHEROSCLEROSIS, V117, P25, DOI 10.1016/0021-9150(95)05546-9
   Vogel RA, 2000, J AM COLL CARDIOL, V36, P1455, DOI 10.1016/S0735-1097(00)00896-2
   Weinbrenner T, 2004, J NUTR, V134, P2314, DOI 10.1093/jn/134.9.2314
   WILLETT WC, 1995, AM J CLIN NUTR, V61, p1402S, DOI 10.1093/ajcn/61.6.1402S
   Wiseman SA, 2002, LIPIDS, V37, P1053, DOI 10.1007/s11745-002-1000-5
   Wu TY, 2007, AM J EPIDEMIOL, V166, P544, DOI 10.1093/aje/kwm120
   Zhang YJ, 2002, CARCINOGENESIS, V23, P207, DOI 10.1093/carcin/23.1.207
NR 68
TC 16
Z9 20
U1 2
U2 35
PU COLLEGIUM ANTROPOLOGICUM
PI ZAGREB
PA INST ANTHROPOLOGICAL RESEARCH, GAJEVA 32, PO BOX 290, HR-10000 ZAGREB,
   CROATIA
SN 0350-6134
J9 COLLEGIUM ANTROPOL
JI Coll. Anthropol.
PD DEC
PY 2012
VL 36
IS 4
BP 1427
EP 1434
PG 8
WC Anthropology
WE Social Science Citation Index (SSCI)
SC Anthropology
GA 076ZY
UT WOS:000313998900050
PM 23390845
DA 2025-06-11
ER

PT J
AU Kawamoto, R
   Imamura, T
   Kawabata, K
   Date, H
   Ishikawa, T
   Maeno, M
   Nagoshi, T
   Fujiura, Y
   Matsuyama, A
   Matsuo, T
   Koiwaya, Y
   Eto, T
AF Kawamoto, R
   Imamura, T
   Kawabata, K
   Date, H
   Ishikawa, T
   Maeno, M
   Nagoshi, T
   Fujiura, Y
   Matsuyama, A
   Matsuo, T
   Koiwaya, Y
   Eto, T
TI Microvascular angina in a patient with aortic stenosis
SO JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION
LA English
DT Article
DE aortic stenosis; coronary flow reserve; Doppler flow wire; microvascular
   angina; papaverine
ID NORMAL CORONARY-ARTERIES; VENTRICULAR-FUNCTION; CHEST PAIN; SYNDROME-X;
   RESERVE; PECTORIS; MECHANISMS; HYPERTROPHY; PAPAVERINE; METABOLISM
AB A 39-year-old woman had exercise-induced ST segment depression associated with chest pain. Cardiac evaluation revealed moderate aortic stenosis (AS), related to the bicuspid valves, with an aortic mean pressure gradient of 22 mmHg, a calculated aortic valve area of 1.3 cm(2) and normal left ventricular (LV) peak systolic and end-diastolic pressures, but no LV hypertrophy, resulting in normal LV wall stress. Although the coronary arteries were angiographically normal, rapid atrial pacing and an intracoronary papaverine injection revealed a significantly decreased coronary flow reserve (CFR), which may have played an important role in the pathogenesis of angina pectoris in this patient. Though the CFR is usually decreased in patients with AS, as well as in microvascular angina, in this particular case, it appeared to have decreased as a consequence of microvascular dysfunction rather than of AS-related mechanisms.
C1 Miyazaki Med Coll, Dept Internal Med 1, Miyazaki 8891692, Japan.
C3 University of Miyazaki
RP Miyazaki Med Coll, Dept Internal Med 1, 5200 Kihara, Miyazaki 8891692, Japan.
CR [Anonymous], HEART DIS TXB CARDIO
   Baumgart D, 1998, AM HEART J, V136, P136, DOI 10.1016/S0002-8703(98)70194-2
   BUCKBERG G, 1975, AM J CARDIOL, V35, P778, DOI 10.1016/0002-9149(75)90112-5
   CAMICI PG, 1992, CIRCULATION, V86, P179, DOI 10.1161/01.CIR.86.1.179
   CANNON RO, 1988, AM J CARDIOL, V61, P1338, DOI 10.1016/0002-9149(88)91180-0
   CHAUHAN A, 1994, CIRCULATION, V89, P1998, DOI 10.1161/01.CIR.89.5.1998
   CHRISTENSEN CW, 1991, CIRCULATION, V83, P294, DOI 10.1161/01.CIR.83.1.294
   FALLEN EL, 1967, CIRCULATION, V36, P480, DOI 10.1161/01.CIR.36.4.480
   Gould KL, 1997, CIRCULATION, V95, P790
   GREENBERG MA, 1987, J AM COLL CARDIOL, V9, P743, DOI 10.1016/S0735-1097(87)80227-9
   GROSSMAN W, 1975, J CLIN INVEST, V56, P56, DOI 10.1172/JCI108079
   HAKKI AH, 1980, AM HEART J, V100, P441, DOI 10.1016/0002-8703(80)90655-9
   HITTINGER L, 1995, CIRCULATION, V92, P978, DOI 10.1161/01.CIR.92.4.978
   IMAMURA T, 1994, CIRC RES, V75, P418, DOI 10.1161/01.RES.75.3.418
   Julius BK, 1997, CIRCULATION, V95, P892
   KEMP HG, 1973, AM J CARDIOL, V32, P375, DOI 10.1016/S0002-9149(73)80150-X
   LIKOFF W, 1967, NEW ENGL J MED, V276, P1063, DOI 10.1056/NEJM196705112761904
   MANDAL AB, 1976, BRIT HEART J, V38, P811
   MARCUS ML, 1982, NEW ENGL J MED, V307, P1362, DOI 10.1056/NEJM198211253072202
   MASERI A, 1991, J AM COLL CARDIOL, V17, P499, DOI 10.1016/S0735-1097(10)80122-6
   NADELL R, 1983, J AM COLL CARDIOL, V2, P258, DOI 10.1016/S0735-1097(83)80161-2
   Nagayama M, 1996, JPN CIRC J, V60, P876, DOI 10.1253/jcj.60.876
NR 22
TC 9
Z9 10
U1 0
U2 0
PU BLACKWELL PUBLISHING ASIA
PI CARLTON
PA 54 UNIVERSITY ST, P O BOX 378, CARLTON, VICTORIA 3053, AUSTRALIA
SN 0047-1828
J9 JPN CIRC J
JI Jpn. Circ. J.-Engl. Ed.
PD SEP
PY 2001
VL 65
IS 9
BP 839
EP 841
DI 10.1253/jcj.65.839
PG 3
WC History & Philosophy Of Science; Social Sciences, Biomedical; Peripheral
   Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC History & Philosophy of Science; Biomedical Social Sciences;
   Cardiovascular System & Cardiology
GA 467DC
UT WOS:000170684400016
PM 11548887
OA Bronze
DA 2025-06-11
ER

PT J
AU Girijala, RL
   Sohrabji, F
   Bush, RL
AF Girijala, Raghavendra L.
   Sohrabji, Farida
   Bush, Ruth L.
TI Sex differences in stroke: Review of current knowledge and evidence
SO VASCULAR MEDICINE
LA English
DT Review
DE sex differences; stroke; women
ID TISSUE-PLASMINOGEN ACTIVATOR; UNITED-STATES REGISTRY; ACUTE
   ISCHEMIC-STROKE; FIBROMUSCULAR DYSPLASIA; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; POSTSTROKE DEPRESSION; CLINICAL PRESENTATION;
   GENDER-DIFFERENCES; MEDICAL-CARE
AB Stroke is a leading cause of death among women in the United States, and women are more affected by stroke than men. With women living longer than men, women experience not only a higher incidence of stroke but also more negative outcomes. Despite its lethal impact and high morbidity rate, the road from innovative bench research to improved clinical outcomes has been slow. This review explores the differential physiology, epidemiology, and clinical presentation of stroke between men and women, as well as the current status of laboratory and clinical data.
C1 [Girijala, Raghavendra L.; Sohrabji, Farida] Texas A&M Univ, Coll Med, College Stn, TX 77843 USA.
   [Bush, Ruth L.] Baylor Coll Med, Houston, TX 77030 USA.
C3 Texas A&M University System; Texas A&M University College Station;
   Baylor College of Medicine
RP Bush, RL (corresponding author), Baylor Coll Med, Ctr Innovat Qual Effectiveness & Safety IQuESt, Michael E DeBakey Vet Affairs Med Ctr, 2002 Holcombe Blvd 152, Houston, TX 77030 USA.
EM rbush@bcm.edu
OI Sohrabji, Farida/0000-0002-6960-3411
CR Alamowitch S, 2005, STROKE, V36, P27, DOI 10.1161/01.STR.0000149622.12636.1f
   Amarenco P, 2009, CEREBROVASC DIS, V27, P493, DOI 10.1159/000210432
   ANKARCRONA M, 1995, NEURON, V15, P961, DOI 10.1016/0896-6273(95)90186-8
   Aoki J, 2011, NEUROTHERAPEUTICS, V8, P463, DOI 10.1007/s13311-011-0054-0
   Appelros P, 2010, ACTA NEUROL SCAND, V121, P359, DOI 10.1111/j.1600-0404.2009.01258.x
   Appelros P, 2009, STROKE, V40, P1082, DOI 10.1161/STROKEAHA.108.540781
   Arauz A, 2011, NEUROLOGIA, V26, P279, DOI 10.1016/j.nrl.2010.10.010
   Arboix A, 2001, EUR NEUROL, V45, P199, DOI 10.1159/000052130
   Bailey AL, 2009, ARTERIOSCL THROM VAS, V29, P284, DOI 10.1161/ATVBAHA.108.179788
   Bake S, 2016, ENDOCRINOLOGY, V157, P61, DOI 10.1210/en.2015-1840
   Bake S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0091427
   Barr J, 2006, NEUROEPIDEMIOLOGY, V26, P168, DOI 10.1159/000091659
   Barrett Kevin M, 2007, J Stroke Cerebrovasc Dis, V16, P34, DOI 10.1016/j.jstrokecerebrovasdis.2006.11.002
   Bartke A, 2008, AGING CELL, V7, P285, DOI 10.1111/j.1474-9726.2008.00387.x
   Béjot Y, 2016, REV NEUROL-FRANCE, V172, P59, DOI 10.1016/j.neurol.2015.07.013
   Berger JS, 2006, JAMA-J AM MED ASSOC, V295, P306, DOI 10.1001/jama.295.3.306
   Brenner B, 2004, THROMB RES, V114, P409, DOI 10.1016/j.thromres.2004.08.004
   BUCHANAN DS, 1970, ARCH NEUROL-CHICAGO, V22, P440, DOI 10.1001/archneur.1970.00480230058006
   Carandang R, 2006, JAMA-J AM MED ASSOC, V296, P2939, DOI 10.1001/jama.296.24.2939
   Cheung RTF, 2001, J CLIN NEUROSCI, V8, P311, DOI 10.1054/jocn.2000.0805
   Coutinho JM, 2009, STROKE, V40, P2356, DOI 10.1161/STROKEAHA.108.543884
   Coylewright M, 2008, HYPERTENSION, V51, P952, DOI 10.1161/HYPERTENSIONAHA.107.105742
   Demirgil BT, 2003, MINIM INVAS NEUROSUR, V46, P344, DOI 10.1055/s-2003-812500
   Deng YZ, 2006, NEUROLOGY, V66, P306, DOI 10.1212/01.wnl.0000196478.77152.fc
   Derex L, 2002, STROKE, V33, P153, DOI 10.1161/hs0102.100533
   Di Carlo A, 2003, STROKE, V34, P1114, DOI 10.1161/01.STR.0000068410.07397.D7
   Dirnagl U, 1999, TRENDS NEUROSCI, V22, P391, DOI 10.1016/S0166-2236(99)01401-0
   Donnan GA, 2008, LANCET, V371, P1612, DOI 10.1016/S0140-6736(08)60694-7
   Dua A, 2016, J VASC SURG, V64, P663, DOI 10.1016/j.jvs.2016.03.428
   Dubal DB, 1999, J NEUROSCI, V19, P6385
   Farhat MY, 1996, FASEB J, V10, P615, DOI 10.1096/fasebj.10.5.8621060
   Feigin VL, 2009, LANCET NEUROL, V8, P355, DOI 10.1016/S1474-4422(09)70025-0
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Gall SL, 2010, NEUROLOGY, V74, P975, DOI 10.1212/WNL.0b013e3181d5a48f
   Gargano JW, 2008, STROKE, V39, P24, DOI 10.1161/STROKEAHA.107.493262
   Gargano JW, 2007, STROKE, V38, P2541, DOI 10.1161/STROKEAHA.107.485482
   Geary GG, 2000, AM J PHYSIOL-HEART C, V279, pH511, DOI 10.1152/ajpheart.2000.279.2.H511
   Gibson CL, 2005, EXP NEUROL, V193, P522, DOI 10.1016/j.expneurol.2005.01.009
   Glader EL, 2003, STROKE, V34, P1970, DOI 10.1161/01.STR.0000083534.81284.C5
   GLUCKMAN P, 1992, BIOCHEM BIOPH RES CO, V182, P593, DOI 10.1016/0006-291X(92)91774-K
   Hagberg H, 2004, J NEUROCHEM, V90, P1068, DOI 10.1111/j.1471-4159.2004.02547.x
   Holroyd-Leduc JM, 2000, STROKE, V31, P1833, DOI 10.1161/01.STR.31.8.1833
   HOWARD G, 1994, STROKE, V25, P2120, DOI 10.1161/01.STR.25.11.2120
   Howard VJ, 2011, LANCET NEUROL, V10, P530, DOI 10.1016/S1474-4422(11)70080-1
   Hurn PD, 2003, STROKE, V34, P338, DOI 10.1161/01.STR.0000054051.88378.25
   Jerath NU, 2011, GENDER MED, V8, P312, DOI 10.1016/j.genm.2011.08.001
   JONES JI, 1995, ENDOCR REV, V16, P3, DOI 10.1210/er.16.1.3
   Jorge RE, 2003, AM J PSYCHIAT, V160, P1823, DOI 10.1176/appi.ajp.160.10.1823
   Jouyandeh Z, 2013, J DIABETES METAB DIS, V12, DOI 10.1186/2251-6581-12-1
   Kapral MK, 2000, J WOMEN HEALTH GEN-B, V9, P987, DOI 10.1089/15246090050200015
   KATSUKI H, 1995, PROG NEUROBIOL, V46, P607, DOI 10.1016/0301-0082(95)00016-O
   Kemmeren JM, 2002, STROKE, V33, P1202, DOI 10.1161/01.STR.0000015345.61324.3F
   Kim Esther S H, 2016, Curr Treat Options Cardiovasc Med, V18, P37, DOI 10.1007/s11936-016-0460-z
   Kim ESH, 2013, J AM COLL CARDIOL, V62, P2026, DOI 10.1016/j.jacc.2013.07.038
   Kisialiou A, 2014, J NEUROL SCI, V339, P41, DOI 10.1016/j.jns.2014.01.014
   Kissela BM, 2005, DIABETES CARE, V28, P355, DOI 10.2337/diacare.28.2.355
   Krause DN, 2006, J APPL PHYSIOL, V101, P1252, DOI 10.1152/japplphysiol.01095.2005
   Laaksonen DE, 2004, DIABETES CARE, V27, P1036, DOI 10.2337/diacare.27.5.1036
   Labiche LA, 2002, ANN EMERG MED, V40, P453, DOI 10.1067/mem.2002.128682
   Lacy CR, 2001, STROKE, V32, P63, DOI 10.1161/01.STR.32.1.63
   Laughlin GA, 2004, J CLIN ENDOCR METAB, V89, P114, DOI 10.1210/jc.2003-030967
   Lenzi GL, 2008, REV NEUROL-FRANCE, V164, P837, DOI 10.1016/j.neurol.2008.07.010
   Lipton P, 1999, PHYSIOL REV, V79, P1431, DOI 10.1152/physrev.1999.79.4.1431
   Lisabeth L, 2012, LANCET NEUROL, V11, P82, DOI 10.1016/S1474-4422(11)70269-1
   Liu FD, 2009, STROKE, V40, P1842, DOI 10.1161/STROKEAHA.108.538686
   Lo EH, 2003, NAT REV NEUROSCI, V4, P399, DOI 10.1038/nrn1106
   Mandelzweig L, 2006, STROKE, V37, P1248, DOI 10.1161/01.STR.0000217200.61167.39
   Mathiesen EB, 2001, CEREBROVASC DIS, V12, P44, DOI 10.1159/000047680
   Menon SC, 1998, NEUROLOGY, V51, P427, DOI 10.1212/WNL.51.2.427
   Morey AK, 1997, ENDOCRINOLOGY, V138, P3330, DOI 10.1210/en.138.8.3330
   Moskowitz MA, 2010, NEURON, V67, P181, DOI 10.1016/j.neuron.2010.07.002
   Mozaffarian D, 2016, CIRCULATION, V133, pE38, DOI 10.1161/CIR.0000000000000350
   Nakamura Y, 2005, ENDOCR J, V52, P245, DOI 10.1507/endocrj.52.245
   Nowacki P, 2007, EUR NEUROL, V58, P159, DOI 10.1159/000104717
   Olin JW, 2014, CIRCULATION, V129, P1048, DOI 10.1161/01.cir.0000442577.96802.8c
   Olin JW, 2012, CIRCULATION, V125, P3182, DOI 10.1161/CIRCULATIONAHA.112.091223
   Ozacmak VH, 2009, PHYSIOL RES, V58, P909, DOI 10.33549/physiolres.931647
   PATRICK SJ, 1995, STROKE, V26, P577, DOI 10.1161/01.STR.26.4.577
   Persky Rebecca W, 2010, Curr Cardiol Rep, V12, P6, DOI 10.1007/s11886-009-0080-2
   Peters SAE, 2014, LANCET, V383, P1973, DOI 10.1016/S0140-6736(14)60040-4
   Petrea RE, 2009, STROKE, V40, P1032, DOI 10.1161/STROKEAHA.108.542894
   Petty GW, 1999, STROKE, V30, P2513, DOI 10.1161/01.STR.30.12.2513
   Pohjasvaara T, 2001, EUR J NEUROL, V8, P315, DOI 10.1046/j.1468-1331.2001.00182.x
   Poynter B, 2009, PSYCHOSOMATICS, V50, P563, DOI 10.1176/appi.psy.50.6.563
   Rangel-Castilla L, 2016, J CARDIOVASC SURG, V57, P36
   Rau SW, 2003, J NEUROSCI, V23, P11420
   Reed SD, 2001, STROKE, V32, P1832, DOI 10.1161/01.STR.32.8.1832
   Reeves MJ, 2008, LANCET NEUROL, V7, P915, DOI 10.1016/S1474-4422(08)70193-5
   Reinhard M, 2015, EUR J NEUROL, V22, P736, DOI 10.1111/ene.12602
   Romero Jose Rafael, 2008, Ther Adv Cardiovasc Dis, V2, P287, DOI 10.1177/1753944708093847
   Rossnagel K, 2004, ANN EMERG MED, V44, P476, DOI 10.1016/j.annemergmed.2004.06.019
   Sacco RL., 2001, Stroke Prevention, P17
   Samai AA, 2015, VASC HEALTH RISK MAN, V11, P427, DOI 10.2147/VHRM.S65886
   Schievink WI, 2005, FRONT NEUROL NEUROSC, V20, P12, DOI 10.1159/000088125
   Selvamani A, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0032662
   Selvamani A, 2010, J NEUROSCI, V30, P6852, DOI 10.1523/JNEUROSCI.0761-10.2010
   Smith MA, 2010, STROKE, V41, P905, DOI 10.1161/STROKEAHA.110.578112
   Sohrabji F, 2015, FRONT NEUROENDOCRIN, V36, P1, DOI 10.1016/j.yfrne.2014.05.003
   Stewart S, 2002, AM J MED, V113, P359, DOI 10.1016/S0002-9343(02)01236-6
   Towfighi A, 2007, NEUROLOGY, V69, P1898, DOI 10.1212/01.wnl.0000268491.89956.c2
   Tuttolomondo A, 2008, INT J CARDIOL, V125, P391, DOI 10.1016/j.ijcard.2007.03.109
   van Gijn J, 2001, BRAIN, V124, P249, DOI 10.1093/brain/124.2.249
   Wang JP, 2010, BEHAV BRAIN RES, V209, P119, DOI 10.1016/j.bbr.2010.01.026
   Welter BH, 2003, J HISTOCHEM CYTOCHEM, V51, P1049, DOI 10.1177/002215540305100808
   West LA., 65 US 2010
   WOLF PA, 1992, STROKE, V23, P1551, DOI 10.1161/01.STR.23.11.1551
   Wong R, 2013, J CEREBR BLOOD F MET, V33, P1362, DOI 10.1038/jcbfm.2013.120
   Yeap BB, 2009, J CLIN ENDOCR METAB, V94, P2353, DOI 10.1210/jc.2008-2416
   Yoon PW, 2014, MMWR-MORBID MORTAL W, V63, P369
   Zoerle T, 2015, CRIT CARE MED, V43, P168, DOI 10.1097/CCM.0000000000000670
NR 110
TC 102
Z9 112
U1 0
U2 12
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1358-863X
EI 1477-0377
J9 VASC MED
JI Vasc. Med.
PD APR
PY 2017
VL 22
IS 2
BP 135
EP 145
DI 10.1177/1358863X16668263
PG 11
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA ET2QJ
UT WOS:000400118900009
PM 27815349
DA 2025-06-11
ER

PT J
AU Derme, M
   Briante, M
   Ceccanti, M
   Giannini, G
   Vitali, M
   Messina, MP
   Piccioni, MG
   Mattia, A
   Nicotera, S
   Crognale, A
AF Derme, Martina
   Briante, Martina
   Ceccanti, Mauro
   Giannini, Giuseppe
   Vitali, Mario
   Messina, Marisa Patrizia
   Piccioni, Maria Grazia
   Mattia, Alessandro
   Nicotera, Simona
   Crognale, Alba
TI Prenatal Alcohol Exposure and Metabolic Disorders in Pediatrics: The
   Role of the Oxidative Stress-A Review of the Literature
SO CHILDREN-BASEL
LA English
DT Review
DE fetal alcohol spectrum disorder (FASD); prenatal alcohol exposure (PAE);
   oxidative stress; metabolic disorders
ID CONGENITAL HEART-DISEASE; SPECTRUM DISORDERS; MEDITERRANEAN DIET; GROWTH
   RESTRICTION; ETHYL GLUCURONIDE; ANIMAL-MODELS; LIVER-DISEASE; HUMAN
   BRAIN; ETHANOL; CHILDREN
AB Prenatal alcohol exposure is responsible for increasing chronic disease risk in later life, including obesity and metabolic syndrome. Alcohol drinking may compromise endogenous antioxidant capacity, causing an increase in free radicals and reactive oxygen species in the newborn. Excessive reactive oxygen species could attack the cellular proteins, lipids, and nucleic acids, leading to cellular dysfunction. Moreover, oxidative stress could play a crucial role in the altered synthesis and release of neurotrophins and progressive mitochondrial modifications with uncontrolled apoptosis. This narrative review aims to underline the important role of alcohol abuse in oxidative stress events and consequent metabolic and neurocognitive impairments in children exposed to alcohol during gestational life.
C1 [Derme, Martina; Briante, Martina; Messina, Marisa Patrizia; Piccioni, Maria Grazia; Crognale, Alba] Sapienza Univ Rome, Dept Maternal Infantile & Urol Sci, Viale Policlin 155, I-00161 Rome, Italy.
   [Ceccanti, Mauro] Italian Soc Treatment Alcoholism & Its Complicat S, I-00185 Rome, Italy.
   [Giannini, Giuseppe] Sapienza Univ Rome, Dept Mol Med, Viale Regina Elena 291, I-00161 Rome, Italy.
   [Vitali, Mario] ASUR Marche, AV4, I-60122 Ancona, Italy.
   [Mattia, Alessandro; Nicotera, Simona] Minist Interno, Dipartimento Pubbl Sicurezza, Ctr di Ric & Lab Tossicol Forense, Direzione Cent Sanita, I-00185 Rome, Italy.
C3 Sapienza University Rome; Sapienza University Rome
RP Ceccanti, M (corresponding author), Italian Soc Treatment Alcoholism & Its Complicat S, I-00185 Rome, Italy.
EM martina.derme@uniroma1.it; mauro.ceccanti@uniroma1.it;
   mariagrazia.piccioni@uniroma1.it; alba.crognale@uniroma1.it
RI Derme, Martina/IRZ-4288-2023; Ceccanti, Mauro/MVW-1162-2025; Porpora,
   Maria Grazia/F-6745-2011; Messina, Marisa/O-6808-2018
OI Mattia, Alessandro/0000-0002-9051-4018; DERME,
   MARTINA/0000-0003-2500-4166; Crognale, Alba/0009-0007-4860-251X
CR Aganovic Izet, 2007, EJIFCC, V18, P3
   Al-Yasari A, 2021, ENDOCRINOLOGY, V162, DOI 10.1210/endocr/bqaa188
   ALOE L, 1992, ALCOHOL, V9, P299, DOI 10.1016/0741-8329(92)90070-Q
   Amos-Kroohs RM, 2016, J PEDIATR-US, V169, P194, DOI 10.1016/j.jpeds.2015.10.049
   [Anonymous], 2015, The Mediterranean Diet: An Evidence-Based Approach, DOI DOI 10.1016/B978-0-12-407849-9.00029-4
   Aragón AS, 2008, ALCOHOL CLIN EXP RES, V32, P2136, DOI 10.1111/j.1530-0277.2008.00802.x
   Asiedu B, 2021, BIRTH DEFECTS RES, V113, P451, DOI 10.1002/bdr2.1881
   Beckhauser TF, 2016, J EXP NEUROSCI, V10, P23, DOI 10.4137/JEN.S39887
   Bekkouche L, 2014, HORM METAB RES, V46, P274, DOI 10.1055/s-0033-1363657
   Biffen SC, 2022, ALCOHOL CLIN EXP RES, V46, P517, DOI 10.1111/acer.14795
   Blanck-Lubarsch M, 2023, FRONT PEDIATR, V11, DOI 10.3389/fped.2023.1169570
   Bloomfield HE, 2016, ANN INTERN MED, V165, P491, DOI 10.7326/M16-0361
   Boschen KE, 2017, VITAM HORM, V104, P197, DOI 10.1016/bs.vh.2016.10.008
   Bosco C, 2012, ALCOHOL ALCOHOLISM, V47, P109, DOI 10.1093/alcalc/agr166
   Brems C, 2014, J POPUL THER CLIN PH, V21, pE159
   Burd L, 2012, J PERINATOL, V32, P652, DOI 10.1038/jp.2012.57
   Burd L, 2016, BMC PSYCHIATRY, V16, DOI 10.1186/s12888-016-1028-x
   Burd Larry, 2007, Congenit Heart Dis, V2, P250, DOI 10.1111/j.1747-0803.2007.00105.x
   Cararo JH, 2022, DEV NEUROBIOL, V82, P29, DOI 10.1002/dneu.22855
   Carito V, 2019, CURR NEUROPHARMACOL, V17, P308, DOI 10.2174/1570159X15666170825101308
   Carito V, 2017, NUTRITION, V33, P65, DOI 10.1016/j.nut.2016.08.014
   Carmichael SL, 2003, BIRTH DEFECTS RES A, V67, P875, DOI 10.1002/bdra.10087
   Carvalho C, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00806
   Ceci FM, 2022, CURR MED CHEM, V29, P3125, DOI 10.2174/0929867328666211125100329
   Chandran S, 2021, PSYCHIAT RES-NEUROIM, V318, DOI 10.1016/j.pscychresns.2021.111405
   Chang GC, 2023, ALCOHOL RES-CURR REV, V43, DOI 10.35946/arcr.v43.1.02
   Ciafrè S, 2019, BIOCHEM CELL BIOL, V97, P345, DOI 10.1139/bcb-2018-0248
   Cohen-Kerem R, 2003, NEUROTOXICOL TERATOL, V25, P1, DOI 10.1016/S0892-0362(02)00324-0
   Colak E, 2021, J MED BIOCHEM, V40, P1, DOI 10.5937/jomb0-24652
   Coriale G, 2013, RIV PSICHIATR, V48, P359, DOI 10.1708/1356.15062
   Dembele K, 2006, AM J PHYSIOL-REG I, V291, pR796, DOI 10.1152/ajpregu.00633.2005
   Denny L, 2017, AM FAM PHYSICIAN, V96, P515
   Denys K, 2011, COMMUNITY MENT HLT J, V47, P209, DOI 10.1007/s10597-009-9273-9
   Derme M, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12061216
   DeVallance E, 2019, ANTIOXID REDOX SIGN, V31, P687, DOI 10.1089/ars.2018.7674
   Dolk H, 2011, CIRCULATION, V123, P841, DOI 10.1161/CIRCULATIONAHA.110.958405
   Donald KA, 2015, ACTA NEUROPSYCHIATR, V27, P251, DOI 10.1017/neu.2015.12
   England LJ, 2020, MMWR-MORBID MORTAL W, V69, P1009, DOI 10.15585/mmwr.mm6931a1
   Ercan S, 2009, ANATOL J CARDIOL, V9, P486
   Faienza MF, 2012, HORM RES PAEDIAT, V78, P158, DOI 10.1159/000342642
   Ferraguti G, 2017, TOXICOL LETT, V275, P49, DOI 10.1016/j.toxlet.2017.04.016
   Ferraguti G, 2015, CURR MED CHEM, V22, P670, DOI 10.2174/0929867321666141229103158
   Fiore M, 2009, NEUROTOXICOLOGY, V30, P59, DOI 10.1016/j.neuro.2008.11.009
   Fiore M, 2022, CNS NEUROL DISORD-DR, V21, P854, DOI 10.2174/1871527320666211201154839
   Fiore M, 2020, J FUNCT FOODS, V71, DOI 10.1016/j.jff.2020.104012
   Forrester SJ, 2018, CIRC RES, V122, P877, DOI 10.1161/CIRCRESAHA.117.311401
   Fuglestad AJ, 2014, ALCOHOL CLIN EXP RES, V38, P2502, DOI 10.1111/acer.12516
   Fuglestad AJ, 2013, NEUROTOXICOL TERATOL, V39, P128, DOI 10.1016/j.ntt.2013.06.005
   Gårdebjer EM, 2018, AM J PHYSIOL-ENDOC M, V315, pE694, DOI 10.1152/ajpendo.00251.2017
   Gaschler MM, 2017, BIOCHEM BIOPH RES CO, V482, P419, DOI 10.1016/j.bbrc.2016.10.086
   Giacosa A, 2016, CRIT REV FOOD SCI, V56, P635, DOI 10.1080/10408398.2012.747484
   Glymour MM, 2014, BMJ-BRIT MED J, V349, DOI 10.1136/bmj.g4334
   Goulden KJ, 2005, CAN MED ASSOC J, V173, P1070, DOI 10.1503/cmaj.1050107
   Greenfield V, 2008, CURR OPIN GASTROEN, V24, P320, DOI 10.1097/MOG.0b013e3282fbccf2
   Gundogan F, 2008, PLACENTA, V29, P148, DOI 10.1016/j.placenta.2007.10.002
   Gupta KK, 2016, ALCOHOL CLIN EXP RES, V40, P1594, DOI 10.1111/acer.13135
   Han TS, 2016, JRSM CARDIOVASC DIS, V5, DOI 10.1177/2048004016633371
   He Z, 2015, SCI REP-UK, V5, DOI 10.1038/srep17679
   Hornedo-Ortega R, 2018, FRONT CELL NEUROSCI, V12, DOI 10.3389/fncel.2018.00373
   Hoyme HE, 2016, PEDIATRICS, V138, DOI 10.1542/peds.2015-4256
   Hwang H, 2023, ALCOHOL CLIN EXP RES, V47, P643, DOI 10.1111/acer.15026
   Jarmasz JS, 2017, J NEUROPATH EXP NEUR, V76, P813, DOI 10.1093/jnen/nlx064
   Jenkins KJ, 2007, CIRCULATION, V115, P2995, DOI 10.1161/CIRCULATIONAHA.106.183216
   Joya X, 2015, BIOANALYSIS, V7, P1273, DOI 10.4155/bio.15.60
   Joya X, 2015, BIRTH DEFECTS RES A, V103, P163, DOI 10.1002/bdra.23290
   Juan CA, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22094642
   Kalberg WO, 2007, NEUROSCI BIOBEHAV R, V31, P278, DOI 10.1016/j.neubiorev.2006.06.014
   Kane CJM, 2021, J NEUROSCI RES, V99, P1973, DOI 10.1002/jnr.24735
   Kesavan K, 2019, PEDIATR CLIN N AM, V66, P403, DOI 10.1016/j.pcl.2018.12.009
   Kumar A, 2011, MOL PHARMACOL, V80, P446, DOI 10.1124/mol.111.071126
   Lange S, 2017, JAMA PEDIATR, V171, P948, DOI 10.1001/jamapediatrics.2017.1919
   Liu QY, 2016, ARCH GYNECOL OBSTET, V294, P225, DOI 10.1007/s00404-016-4109-7
   Ojeda ML, 2021, NUTRIENTS, V13, DOI 10.3390/nu13062085
   Martino F, 2023, J CARDIOVASC MED, V24, P492, DOI 10.2459/JCM.0000000000001488
   May PA, 2014, PEDIATRICS, V134, P855, DOI 10.1542/peds.2013-3319
   May PA, 2009, DEV DISABIL RES REV, V15, P176, DOI 10.1002/ddrr.68
   McCormack C, 2017, ALCOHOL CLIN EXP RES, V41, P369, DOI 10.1111/acer.13305
   McCormack JC, 2022, RES DEV DISABIL, V131, DOI 10.1016/j.ridd.2022.104354
   Micangeli G, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11101983
   Moore Eileen M, 2015, Curr Dev Disord Rep, V2, P219
   Morini L, 2010, FORENSIC SCI INT, V196, P74, DOI 10.1016/j.forsciint.2009.12.035
   Morini L, 2010, THER DRUG MONIT, V32, P359, DOI 10.1097/FTD.0b013e3181d5f14a
   Morrison JL, 2010, PEDIATR NEPHROL, V25, P669, DOI 10.1007/s00467-009-1407-3
   Murawski NJ, 2015, ALCOHOL RES-CURR REV, V37, P97
   Nguyen VT, 2017, MAGN RESON IMAGING, V43, P10, DOI 10.1016/j.mri.2017.06.012
   Nguyen VB, 2014, PHYSIOL REP, V2, DOI 10.14814/phy2.12087
   Ninh VK, 2019, TOXICOL LETT, V315, P87, DOI 10.1016/j.toxlet.2019.08.010
   Nolfi-Donegan D, 2020, REDOX BIOL, V37, DOI 10.1016/j.redox.2020.101674
   Onesimo R, 2019, ITAL J PEDIATR, V45, DOI 10.1186/s13052-019-0759-y
   Petrella C, 2021, CURR MED CHEM, V28, P7595, DOI 10.2174/0929867328666210504113445
   Petrella C, 2020, NUTRITION, V79-80, DOI 10.1016/j.nut.2020.110783
   Petrelli B, 2019, GENESIS, V57, DOI 10.1002/dvg.23278
   Pichini S, 2009, J POPUL THER CLIN PH, V16, pE370
   Pichini S, 2012, ALCOHOL CLIN EXP RES, V36, P417, DOI 10.1111/j.1530-0277.2011.01647.x
   Popova S, 2023, NAT REV DIS PRIMERS, V9, DOI 10.1038/s41572-023-00420-x
   Popova S, 2018, BIOCHEM CELL BIOL, V96, P237, DOI 10.1139/bcb-2017-0077
   Popova S, 2017, LANCET GLOB HEALTH, V5, pE290, DOI 10.1016/S2214-109X(17)30021-9
   Premji SS, 2009, CAN J PUBLIC HEALTH, V100, P274, DOI 10.1007/BF03403946
   Ramirez-Tortose M.d.C., 2015, The Mediterranean Diet: An Evidence-Based Approach, P205, DOI [10.1016/B978-0-12-407849-9.00020-8, DOI 10.1016/B978-0-12-407849-9.00020-8]
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   Ray PD, 2012, CELL SIGNAL, V24, P981, DOI 10.1016/j.cellsig.2012.01.008
   Riley EP, 2011, NEUROPSYCHOL REV, V21, P73, DOI 10.1007/s11065-011-9166-x
   Samson SL, 2014, ENDOCRIN METAB CLIN, V43, P1, DOI 10.1016/j.ecl.2013.09.009
   Sari Y, 2004, ALCOHOL CLIN EXP RES, V28, P941, DOI 10.1097/01.ALC.0000128228.08472.39
   Scioli MG, 2020, J CLIN MED, V9, DOI 10.3390/jcm9061995
   Sebastiani G, 2018, NUTRIENTS, V10, DOI 10.3390/nu10081008
   Shen L, 2014, TOXICOL APPL PHARM, V274, P263, DOI 10.1016/j.taap.2013.11.009
   Sherbaf FG, 2019, HUM BRAIN MAPP, V40, P1017, DOI 10.1002/hbm.24409
   Smith S., 2006, Brain Development, DOI [10.1093/acprof:oso/9780195183139.001.0001, DOI 10.1093/ACPROF:OSO/9780195183139.001.0001]
   Terracina S, 2022, CURR NEUROPHARMACOL, V20, P1158, DOI 10.2174/1570159X19666211101111430
   Thomas JD, 2010, ALCOHOL RES HEALTH, V33, P118
   Touyz RM, 2020, CAN J CARDIOL, V36, P659, DOI 10.1016/j.cjca.2020.02.081
   Trichopoulou A, 2000, CANCER EPIDEM BIOMAR, V9, P869
   Tsang TW, 2022, DRUG ALCOHOL REV, V41, P171, DOI 10.1111/dar.13330
   Tunc-Ozcan E, 2014, FRONT GENET, V5, DOI 10.3389/fgene.2014.00261
   Ungerer M, 2013, ALCOHOL RES-CURR REV, V35, P37
   van der Linde D, 2011, J AM COLL CARDIOL, V58, P2241, DOI 10.1016/j.jacc.2011.08.025
   Veith Alex, 2018, Current Opinion in Toxicology, V7, P44, DOI 10.1016/j.cotox.2017.10.003
   Voskoboinik A, 2019, HEART RHYTHM, V16, P251, DOI 10.1016/j.hrthm.2018.10.041
   Weeks O, 2020, J CLIN INVEST, V130, P2252, DOI 10.1172/JCI132139
   Werts RL, 2014, ALCOHOL CLIN EXP RES, V38, P871, DOI 10.1111/acer.12284
   Wilhoit LF, 2017, COMMUNITY MENT HLT J, V53, P711, DOI 10.1007/s10597-017-0104-0
   Wozniak JR, 2019, LANCET NEUROL, V18, P760, DOI 10.1016/S1474-4422(19)30150-4
   Xia LP, 2014, TOXICOL LETT, V226, P98, DOI 10.1016/j.toxlet.2014.01.023
   Yang JM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0130681
   Yao XH, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059680
   Young JK, 2014, ADV NUTR, V5, P675, DOI 10.3945/an.113.004846
   Zhang SM, 2020, EUR J PREV CARDIOL, V27, P410, DOI 10.1177/2047487319874530
   Zhong LL, 2010, CARDIOVASC TOXICOL, V10, P268, DOI 10.1007/s12012-010-9081-z
   Zhu J, 2019, FEMS MICROBIOL LETT, V366, DOI 10.1093/femsle/fnaa015
NR 130
TC 4
Z9 4
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9067
J9 CHILDREN-BASEL
JI Children-Basel
PD MAR
PY 2024
VL 11
IS 3
AR 269
DI 10.3390/children11030269
PG 14
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA MC9Y7
UT WOS:001191557600001
PM 38539304
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lee, MS
AF Lee, Myung-Shik
TI Role of islet β cell autophagy in the pathogenesis of diabetes
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE beta cell; autophagy; obesity; ER stress; islet amyloid
ID ENDOPLASMIC-RETICULUM STRESS; AMYLOID POLYPEPTIDE TOXICITY; REGULATED
   AUTOPHAGY; NLRP3 INFLAMMASOME; OXIDATIVE STRESS; PROTECTIVE ROLE; ER
   STRESS; RAT-LIVER; INSULIN; ACTIVATION
AB While the role of autophagy in the physiology of endocrine organs and the development of metabolic disorders or diabetes has been investigated, the relationship between the pancreatic islet and autophagy has not been explored extensively. In this review, studies on the possible involvement of dysregulated autophagy in the pathogenesis of metabolic syndrome and diabetes will be summarized with an emphasis on the autophagic process in pancreatic islet cells. Novel findings regarding the role of autophagy in human beta cell pathology and the development of type 2 diabetes (T2D) characterized by islet amyloid deposition will be discussed. Careful design of agents enhancing autophagic activity in beta cells might serve as a novel approach towards therapeutics for the treatment of diabetes.
C1 Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med, Seoul 135710, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center
RP Lee, MS (corresponding author), Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med, Seoul 135710, South Korea.
EM mslee0923@skku.edu
RI Lee, Myung/C-9606-2011
FU Global Research Laboratory Grant from the National Research Foundation
   of Korea [2010-00347]; National Research Foundation of Korea
   [2014M3A9D8034459]
FX This study was supported by a Global Research Laboratory Grant
   (2010-00347) from the National Research Foundation of Korea. M.S.L. is
   the recipient of the BioDevelopment Grant (2014M3A9D8034459) from the
   National Research Foundation of Korea.
CR Abe H, 2013, ENDOCRINOLOGY, V154, P4512, DOI 10.1210/en.2013-1578
   ASHFORD TP, 1962, J CELL BIOL, V12, P198, DOI 10.1083/jcb.12.1.198
   Ashrafi G, 2013, CELL DEATH DIFFER, V20, P31, DOI 10.1038/cdd.2012.81
   Bachar-Wikstrom E, 2013, DIABETES, V62, P1227, DOI 10.2337/db12-1474
   Back SH, 2009, CELL METAB, V10, P13, DOI 10.1016/j.cmet.2009.06.002
   Barlow AD, 2013, DIABETES, V62, P2674, DOI 10.2337/db13-0106
   Bartolome A, 2012, AUTOPHAGY, V8, P1757, DOI 10.4161/auto.21994
   Bernales S, 2007, AUTOPHAGY, V3, P285, DOI 10.4161/auto.3930
   Chang I, 2004, J IMMUNOL, V172, P7008, DOI 10.4049/jimmunol.172.11.7008
   Chen ZF, 2013, CHINESE MED J-PEKING, V126, P937, DOI 10.3760/cma.j.issn.0366-6999.20122331
   Choi SE, 2009, ENDOCRINOLOGY, V150, P126, DOI 10.1210/en.2008-0483
   Costes S, 2014, AUTOPHAGY, V10, P1004, DOI 10.4161/auto.28478
   Costes S, 2011, DIABETES, V60, P227, DOI 10.2337/db10-0522
   Cunha DA, 2008, J CELL SCI, V121, P2308, DOI 10.1242/jcs.026062
   DETER RL, 1967, J CELL BIOL, V33, P437, DOI 10.1083/jcb.33.2.437
   Di Bartolomeo S, 2010, J CELL BIOL, V191, P155, DOI 10.1083/jcb.201002100
   Ebato C, 2008, CELL METAB, V8, P325, DOI 10.1016/j.cmet.2008.08.009
   Feuerer M, 2009, NAT MED, V15, P930, DOI 10.1038/nm.2002
   Fraenkel M, 2008, DIABETES, V57, P945, DOI 10.2337/db07-0922
   Fujimoto K, 2009, J BIOL CHEM, V284, P27664, DOI 10.1074/jbc.M109.041616
   Haataja L, 2008, ENDOCR REV, V29, P303, DOI 10.1210/er.2007-0037
   Hamasaki M, 2013, NATURE, V495, P389, DOI 10.1038/nature11910
   Hamasaki M, 2010, FEBS LETT, V584, P1296, DOI 10.1016/j.febslet.2010.02.061
   Han D, 2010, BIOCHEM J, V425, P541, DOI 10.1042/BJ20090429
   He CC, 2012, NATURE, V481, P511, DOI 10.1038/nature10758
   Hiddinga HJ, 2012, J DIABETES INVEST, V3, P138, DOI 10.1111/j.2040-1124.2011.00166.x
   Hosokawa N, 2006, FEBS LETT, V580, P2623, DOI 10.1016/j.febslet.2006.04.008
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Houck SA, 2014, MOL CELL, V54, P166, DOI 10.1016/j.molcel.2014.02.025
   Hoyer-Hansen M, 2007, CELL DEATH DIFFER, V14, P1576, DOI 10.1038/sj.cdd.4402200
   Janson J, 1999, DIABETES, V48, P491, DOI 10.2337/diabetes.48.3.491
   Jayasinghe SA, 2005, BIOCHEMISTRY-US, V44, P12113, DOI 10.1021/bi050840w
   Jiang YL, 2014, INT J BIOL SCI, V10, P268, DOI 10.7150/ijbs.7929
   Jung HS, 2008, CELL METAB, V8, P318, DOI 10.1016/j.cmet.2008.08.013
   Kahn SE, 1999, DIABETES, V48, P241, DOI 10.2337/diabetes.48.2.241
   Kalender A, 2010, CELL METAB, V11, P390, DOI 10.1016/j.cmet.2010.03.014
   Kaniuk NA, 2007, DIABETES, V56, P930, DOI 10.2337/db06-1160
   Kim J, 2014, J CLIN INVEST, V124, P3311, DOI 10.1172/JCI69625
   Kim KH, 2014, NAT REV ENDOCRINOL, V10, P322, DOI 10.1038/nrendo.2014.35
   Kim KH, 2013, BIOCHEM BIOPH RES CO, V440, P76, DOI 10.1016/j.bbrc.2013.09.026
   Klionsky DJ, 2012, AUTOPHAGY, V8, P445, DOI 10.4161/auto.19496
   Koga H, 2010, FASEB J, V24, P3052, DOI 10.1096/fj.09-144519
   Komatsu M, 2007, CELL, V131, P1149, DOI 10.1016/j.cell.2007.10.035
   Komiya K, 2010, BIOCHEM BIOPH RES CO, V401, P561, DOI 10.1016/j.bbrc.2010.09.101
   Kufer TA, 2011, NAT IMMUNOL, V12, P121, DOI 10.1038/ni.1985
   Las G, 2011, J BIOL CHEM, V286, P42534, DOI 10.1074/jbc.M111.242412
   LI WWF, 1993, J BIOL CHEM, V268, P12003
   Lim Y-M., 2014, NAT COMMUN IN PRESS
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Maechler P, 1999, NATURE, V402, P685, DOI 10.1038/45280
   Marsh BJ, 2007, MOL ENDOCRINOL, V21, P2255, DOI 10.1210/me.2007-0077
   Masini M, 2009, DIABETOLOGIA, V52, P1083, DOI 10.1007/s00125-009-1347-2
   Masters SL, 2010, NAT IMMUNOL, V11, P897, DOI 10.1038/ni.1935
   Matsunaga K, 2009, NAT CELL BIOL, V11, P385, DOI 10.1038/ncb1846
   Meier JJ, 2012, NAT REV ENDOCRINOL, V8, P728, DOI 10.1038/nrendo.2012.140
   Merksamer PI, 2008, CELL, V135, P933, DOI 10.1016/j.cell.2008.10.011
   Miklossy J, 2010, NEUROBIOL AGING, V31, P1503, DOI 10.1016/j.neurobiolaging.2008.08.019
   Mizushima N, 2004, MOL BIOL CELL, V15, P1101, DOI 10.1091/mbc.E03-09-0704
   Mizushima N, 2011, CELL, V147, P728, DOI 10.1016/j.cell.2011.10.026
   Mizushima N, 2010, CURR OPIN CELL BIOL, V22, P132, DOI 10.1016/j.ceb.2009.12.004
   Morita S, 2011, J DIABETES INVEST, V2, P48, DOI 10.1111/j.2040-1124.2010.00065.x
   Noyan-Ashraf MH, 2013, CIRCULATION, V127, P74, DOI 10.1161/CIRCULATIONAHA.112.091215
   ORCI L, 1984, J CELL BIOL, V98, P222, DOI 10.1083/jcb.98.1.222
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Park K, 2001, J BIOL CHEM, V276, P16611, DOI 10.1074/jbc.M008423200
   Petersen KF, 2003, SCIENCE, V300, P1140, DOI 10.1126/science.1082889
   PFEIFER U, 1978, J CELL BIOL, V78, P152, DOI 10.1083/jcb.78.1.152
   Pyo JO, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3300
   Quan W, 2012, DIABETOLOGIA, V55, P392, DOI 10.1007/s00125-011-2350-y
   Riboulet-Chavey A, 2008, DIABETES, V57, P415, DOI 10.2337/db07-0993
   Rivera JF, 2011, CELL DEATH DIFFER, V18, P415, DOI 10.1038/cdd.2010.111
   Rivera JF, 2014, J CLIN INVEST, V124, P3489, DOI 10.1172/JCI71981
   Rubinsztein DC, 2006, NATURE, V443, P780, DOI 10.1038/nature05291
   Saitoh T, 2008, NATURE, V456, P264, DOI 10.1038/nature07383
   Sarbassov DD, 2005, CURR OPIN CELL BIOL, V17, P596, DOI 10.1016/j.ceb.2005.09.009
   Sarkar S, 2007, J BIOL CHEM, V282, P5641, DOI 10.1074/jbc.M609532200
   Scheuner D, 2005, NAT MED, V11, P757, DOI 10.1038/nm1259
   Sharma S, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025269
   Shen SS, 2012, AUTOPHAGY, V8, P1, DOI 10.4161/auto.8.1.16618
   Shibata M, 2009, BIOCHEM BIOPH RES CO, V382, P419, DOI 10.1016/j.bbrc.2009.03.039
   Shigihara N, 2014, J CLIN INVEST, V124, P3634, DOI 10.1172/JCI69866
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Singh R, 2009, NATURE, V458, P1131, DOI 10.1038/nature07976
   Steneberg P, 2013, DIABETES, V62, P2004, DOI 10.2337/db12-1045
   Strom A, 2011, PANCREAS, V40, P229, DOI 10.1097/MPA.0b013e3181f7e547
   Tanemura M, 2012, AM J TRANSPLANT, V12, P102, DOI 10.1111/j.1600-6143.2011.03771.x
   Twig G, 2008, EMBO J, V27, P433, DOI 10.1038/sj.emboj.7601963
   Vandanmagsar B, 2011, NAT MED, V17, P179, DOI 10.1038/nm.2279
   Wauson EM, 2014, TRENDS ENDOCRIN MET, V25, P274, DOI 10.1016/j.tem.2014.03.006
   Wen HT, 2011, NAT IMMUNOL, V12, P408, DOI 10.1038/ni.2022
   Westermark P, 2011, PHYSIOL REV, V91, P795, DOI 10.1152/physrev.00042.2009
   Westwell-Roper C, 2011, J IMMUNOL, V187, P2755, DOI 10.4049/jimmunol.1002854
   Wu J, 2013, ENDOCRINE, V44, P87, DOI 10.1007/s12020-012-9826-5
   Yang L, 2010, CELL METAB, V11, P467, DOI 10.1016/j.cmet.2010.04.005
   Yin JJ, 2012, AUTOPHAGY, V8, P158, DOI 10.4161/auto.8.2.18807
   Youm YH, 2011, ENDOCRINOLOGY, V152, P4039, DOI 10.1210/en.2011-1326
   Yu L, 2010, NATURE, V465, P942, DOI 10.1038/nature09076
   Yusta B, 2006, CELL METAB, V4, P391, DOI 10.1016/j.cmet.2006.10.001
NR 98
TC 78
Z9 85
U1 1
U2 35
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD DEC
PY 2014
VL 25
IS 12
BP 620
EP 627
DI 10.1016/j.tem.2014.08.005
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AX8DL
UT WOS:000347140500002
PM 25242548
DA 2025-06-11
ER

PT J
AU Ron, D
   Harding, HP
AF Ron, David
   Harding, Heather P.
TI Protein-Folding Homeostasis in the Endoplasmic Reticulum and Nutritional
   Regulation
SO COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
LA English
DT Article
ID INTEGRATED STRESS-RESPONSE; INDUCED GENE-EXPRESSION; BETA-CELL
   DYSFUNCTION; ER STRESS; SELECTIVE-INHIBITION; EIF2-ALPHA
   DEPHOSPHORYLATION; TRANSLATIONAL REGULATION; GLUCOSE-HOMEOSTASIS;
   MESSENGER-RNAS; ALPHA-SUBUNIT
AB The flux of newly synthesized proteins entering the endoplasmic reticulum (ER) is under negative regulation by the ER-localized PKR-like ER kinase (PERK). PERK is activated by unfolded protein stress in the ER lumen and inhibits new protein synthesis by the phosphorylation of translation initiation factor eIF2 alpha. This homeostatic mechanism, shared by all animal cells, has proven to be especially important to the well-being of professional secretory cells, notably the endocrine pancreas. PERK, its downstream effectors, and the allied branches of the unfolded protein response intersect broadly with signaling pathways that regulate nutrient assimilation, and ER stress and the response to it have been implicated in the development of the metabolic syndrome accompanying obesity in mammals. Here we review our current understanding of the cell biology underlying these relationships.
C1 [Ron, David] Univ Cambridge, Metab Res Labs, Cambridge CB2 0QQ, England.
   Addenbrookes Hosp, NIHR Cambridge Biomed Res Ctr, Cambridge CB2 0QQ, England.
C3 University of Cambridge; Cambridge University Hospitals NHS Foundation
   Trust; Addenbrooke's Hospital; University of Cambridge
RP Ron, D (corresponding author), Univ Cambridge, Metab Res Labs, Cambridge CB2 0QQ, England.
EM dr360@medschl.cam.ac.uk
OI Harding, Heather P/0000-0002-7359-7974; Ron, David/0000-0002-3014-5636
FU Wellcome Trust; EU [277713]; NIH [DK47119]
FX This work is supported by a Wellcome Trust Principal Research Fellowship
   to D.R. and by EU FP7 BetaBat grant 277713 and by NIH grant DK47119.
CR BATCHVAROVA N, 1995, EMBO J, V14, P4654, DOI 10.1002/j.1460-2075.1995.tb00147.x
   Birkenfeld AL, 2011, J BIOL CHEM, V286, P36163, DOI 10.1074/jbc.M111.228817
   Boyce M, 2005, SCIENCE, V307, P935, DOI 10.1126/science.1101902
   Braakman I, 2013, COLD SPRING HARB PER, DOI [10.1101/cshperpsect.a013201, DOI 10.1101/CSHPERPSECT.A013201]
   Brush MH, 2003, MOL CELL BIOL, V23, P1292, DOI 10.1128/MCB.23.4.1292-1303.2003
   Bulleid NJ, 2012, CSH PERSPECT BIOL, V4, DOI 10.1101/cshperspect.a013219
   Campbell SG, 2005, J CELL BIOL, V170, P925, DOI 10.1083/jcb.200503162
   Cnop M, 2007, J BIOL CHEM, V282, P3989, DOI 10.1074/jbc.M607627200
   Colombo C, 2008, J CLIN INVEST, V118, P2148, DOI 10.1172/JCI33777
   Cross BCS, 2012, P NATL ACAD SCI USA, V109, pE869, DOI 10.1073/pnas.1115623109
   CROZAT A, 1993, NATURE, V363, P640, DOI 10.1038/363640a0
   Cunha DA, 2008, J CELL SCI, V121, P2308, DOI 10.1242/jcs.026062
   Cunha DA, 2012, DIABETES, V61, P2763, DOI 10.2337/db12-0123
   Delépine M, 2000, NAT GENET, V25, P406, DOI 10.1038/78085
   Duvillie B, 1997, P NATL ACAD SCI USA, V94, P5137, DOI 10.1073/pnas.94.10.5137
   Elouil H, 2007, DIABETOLOGIA, V50, P1442, DOI 10.1007/s00125-007-0674-4
   Fu SN, 2011, NATURE, V473, P528, DOI 10.1038/nature09968
   Gardner BM, 2013, CSH PERSPECT BIOL, V5, DOI 10.1101/cshperspect.a013169
   Gregor MF, 2009, DIABETES, V58, P693, DOI 10.2337/db08-1220
   Gupta S, 2010, DIABETES, V59, P1937, DOI 10.2337/db09-1064
   Han D, 2009, CELL, V138, P562, DOI 10.1016/j.cell.2009.07.017
   Harding HP, 2009, P NATL ACAD SCI USA, V106, P1832, DOI 10.1073/pnas.0809632106
   Harding HP, 2001, MOL CELL, V7, P1153, DOI 10.1016/S1097-2765(01)00264-7
   Harding HP, 1999, NATURE, V397, P271, DOI 10.1038/16729
   Harding HP, 2000, MOL CELL, V5, P897, DOI 10.1016/S1097-2765(00)80330-5
   Harding HP, 2000, MOL CELL, V6, P1099, DOI 10.1016/S1097-2765(00)00108-8
   Harding HP, 2003, MOL CELL, V11, P619, DOI 10.1016/S1097-2765(03)00105-9
   Harding HP, 2001, COLD SPRING HARB SYM, V66, P499, DOI 10.1101/sqb.2001.66.499
   Hinnebusch AG, 2000, COLD SPRING HARBOR M, V39, P185
   Hollien J, 2006, SCIENCE, V313, P104, DOI 10.1126/science.1129631
   Hollien J, 2009, J CELL BIOL, V186, P323, DOI 10.1083/jcb.200903014
   Ingolia NT, 2011, CELL, V147, P789, DOI 10.1016/j.cell.2011.10.002
   Jousse C, 2003, J CELL BIOL, V163, P767, DOI 10.1083/jcb.200308075
   Julier C, 2010, ORPHANET J RARE DIS, V5, DOI 10.1186/1750-1172-5-29
   Karaskov E, 2006, ENDOCRINOLOGY, V147, P3398, DOI 10.1210/en.2005-1494
   Ladiges WC, 2005, DIABETES, V54, P1074, DOI 10.2337/diabetes.54.4.1074
   Laybutt DR, 2007, DIABETOLOGIA, V50, P752, DOI 10.1007/s00125-006-0590-z
   Lee AH, 2011, P NATL ACAD SCI USA, V108, P8885, DOI 10.1073/pnas.1105564108
   Li YK, 2004, J BIOL CHEM, V279, P37030, DOI 10.1074/jbc.M405195200
   Lin JH, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004170
   Lipson KL, 2006, CELL METAB, V4, P245, DOI 10.1016/j.cmet.2006.07.007
   Lord C, 2013, CSH PERSPECT BIOL, V5, DOI 10.1101/cshperspect.a013367
   Lu PD, 2004, EMBO J, V23, P169, DOI 10.1038/sj.emboj.7600030
   Lu PD, 2004, J CELL BIOL, V167, P27, DOI 10.1083/jcb.200408003
   Ma YJ, 2003, J BIOL CHEM, V278, P34864, DOI 10.1074/jbc.M301107200
   Mandon EC, 2013, COLD SPRING HARB PER, DOI [10.1011/cshperspect.a013342, DOI 10.1011/CSHPERSPECT.A013342]
   Marciniak SJ, 2004, GENE DEV, V18, P3066, DOI 10.1101/gad.1250704
   Maris M, 2012, DIABETOLOGIA, V55, P1167, DOI 10.1007/s00125-011-2427-7
   McCullough KD, 2001, MOL CELL BIOL, V21, P1249, DOI 10.1128/MCB.21.4.1249-1259.2001
   Murakami T, 2009, NAT CELL BIOL, V11, P1205, DOI 10.1038/ncb1963
   Novoa I, 2003, EMBO J, V22, P1180, DOI 10.1093/emboj/cdg112
   Novoa I, 2001, J CELL BIOL, V153, P1011, DOI 10.1083/jcb.153.5.1011
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Olzmann JA, 2013, CSH PERSPECT BIOL, V5, DOI 10.1101/cshperspect.a013185
   Oyadomari S, 2002, J CLIN INVEST, V109, P525, DOI 10.1172/JCI200214550
   Oyadomari S, 2008, CELL METAB, V7, P520, DOI 10.1016/j.cmet.2008.04.011
   Ozcan L, 2009, CELL METAB, V9, P35, DOI 10.1016/j.cmet.2008.12.004
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Promlek T, 2011, MOL BIOL CELL, V22, P3520, DOI 10.1091/mbc.E11-04-0295
   RON D, 1992, GENE DEV, V6, P439, DOI 10.1101/gad.6.3.439
   Scheuner D, 2001, MOL CELL, V7, P1165, DOI 10.1016/S1097-2765(01)00265-9
   Shen XH, 2001, CELL, V107, P893, DOI 10.1016/S0092-8674(01)00612-2
   Shi YG, 1998, MOL CELL BIOL, V18, P7499, DOI 10.1128/MCB.18.12.7499
   Song BB, 2008, J CLIN INVEST, V118, P3378, DOI 10.1172/JCI34587
   Trusina A, 2008, P NATL ACAD SCI USA, V105, P20280, DOI 10.1073/pnas.0803476105
   Tsang KY, 2007, PLOS BIOL, V5, P568, DOI 10.1371/journal.pbio.0050044
   Tsaytler P, 2011, SCIENCE, V332, P91, DOI 10.1126/science.1201396
   Urano F, 2000, SCIENCE, V287, P664, DOI 10.1126/science.287.5453.664
   Vattem KM, 2004, P NATL ACAD SCI USA, V101, P11269, DOI 10.1073/pnas.0400541101
   Virtue S, 2010, BBA-MOL CELL BIOL L, V1801, P338, DOI 10.1016/j.bbalip.2009.12.006
   Wang HY, 2005, J CELL SCI, V118, P3905, DOI 10.1242/jcs.02513
   Wang J, 1999, J CLIN INVEST, V103, P27, DOI 10.1172/JCI4431
   Wei MC, 2001, SCIENCE, V292, P727, DOI 10.1126/science.1059108
   Ye J, 2000, MOL CELL, V6, P1355, DOI 10.1016/S1097-2765(00)00133-7
   Zhang PC, 2002, MOL CELL BIOL, V22, P3864, DOI 10.1128/MCB.22.11.3864-3874.2002
   Zhang XQ, 2008, CELL, V135, P61, DOI 10.1016/j.cell.2008.07.043
   Zhou DH, 2008, J BIOL CHEM, V283, P7064, DOI 10.1074/jbc.M708530200
   Zhou YJ, 2011, NAT MED, V17, P356, DOI 10.1038/nm.2293
   Zinszner H, 1998, GENE DEV, V12, P982, DOI 10.1101/gad.12.7.982
   Zito E, 2010, J CELL BIOL, V188, P821, DOI 10.1083/jcb.200911086
   ZUCKER P, 1975, DIABETES, V24, P194, DOI 10.2337/diabetes.24.2.194
NR 81
TC 78
Z9 85
U1 0
U2 28
PU COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
PI COLD SPRING HARBOR
PA 1 BUNGTOWN RD, COLD SPRING HARBOR, NY 11724 USA
SN 1943-0264
J9 CSH PERSPECT BIOL
JI Cold Spring Harbor Perspect. Biol.
PD DEC
PY 2012
VL 4
IS 12
AR a013177
DI 10.1101/cshperspect.a013177
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 054SL
UT WOS:000312363400017
PM 23209157
OA Green Published, Bronze
DA 2025-06-11
ER

PT S
AU Qi, L
   Yang, L
   Chen, H
AF Qi, Ling
   Yang, Liu
   Chen, Hui
BE Conn, PM
TI DETECTING AND QUANTITATING PHYSIOLOGICAL ENDOPLASMIC RETICULUM STRESS
SO METHODS IN ENZYMOLOGY: UNFOLDED PROTEIN RESPONSE AND CELLULAR STRESS,
   VOL 490, PT B
SE Methods in Enzymology
LA English
DT Review; Book Chapter
ID UNFOLDED PROTEIN RESPONSE; GLUCOSE-HOMEOSTASIS; TRANSLATIONAL CONTROL;
   TRANSCRIPTION FACTOR; BETA-CELLS; PHOSPHORYLATION; PATHWAY;
   OLIGOMERIZATION; MAINTAINS; DISTINCT
AB Unfolded protein response (UPR) is a key cellular defense mechanism associated with many human "conformational" diseases, including heart diseases, neurodegeneration, and metabolic syndrome. One of the major obstacles that have hindered our further understanding of physiological UPR and its future therapeutic potential is our inability to detect and quantitate ER stress and UPR activation under physiological and pathological conditions, where ER stress is perceivably very mild. Here, we describe a Phos-tag-based Western blot approach that allows for direct visualization and quantitative assessment of mild ER stress and UPR signaling, directly at the levels of UPR sensors, in various in vivo conditions. This method will likely pave the foundation for future studies on physiological UPR, aid in the diagnosis of ER-associated diseases, and facilitate therapeutic strategies targeting UPR in vivo.
C1 [Qi, Ling; Chen, Hui] Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA.
   [Qi, Ling; Yang, Liu] Cornell Univ, Grad Program Biochem Mol & Cell Biol, Ithaca, NY USA.
C3 Cornell University; Cornell University
RP Qi, L (corresponding author), Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA.
RI Qi, Ling/KHE-3068-2024
OI Qi, Ling/0000-0001-8229-0184
FU NIDDK NIH HHS [R01 DK082582, R01DK082582] Funding Source: Medline
CR Back SH, 2009, CELL METAB, V10, P13, DOI 10.1016/j.cmet.2009.06.002
   Basseri S, 2009, J LIPID RES, V50, P2486, DOI 10.1194/jlr.M900216-JLR200
   Brewer JW, 1997, EMBO J, V16, P7207, DOI 10.1093/emboj/16.23.7207
   Harding HP, 2001, MOL CELL, V7, P1153, DOI 10.1016/S1097-2765(01)00264-7
   He Y, 2010, GENE EXPRESSION, V15, P13, DOI 10.3727/105221610X12819686555051
   Iwawaki T, 2004, NAT MED, V10, P98, DOI 10.1038/nm970
   Kim I, 2008, NAT REV DRUG DISCOV, V7, P1013, DOI 10.1038/nrd2755
   Kinoshita E, 2006, MOL CELL PROTEOMICS, V5, P749, DOI 10.1074/mcp.T500024-MCP200
   Malhotra JD, 2008, P NATL ACAD SCI USA, V105, P18525, DOI 10.1073/pnas.0809677105
   Masaki T, 1999, BIOCHEM BIOPH RES CO, V261, P350, DOI 10.1006/bbrc.1999.0972
   Miyata Y, 2008, BIOCHEM BIOPH RES CO, V365, P826, DOI 10.1016/j.bbrc.2007.11.045
   Reimold AM, 2000, GENE DEV, V14, P152
   Ron D, 2007, NAT REV MOL CELL BIO, V8, P519, DOI 10.1038/nrm2199
   Scheuner D, 2001, MOL CELL, V7, P1165, DOI 10.1016/S1097-2765(01)00265-9
   Scheuner D, 2005, NAT MED, V11, P757, DOI 10.1038/nm1259
   Sha HB, 2009, CELL METAB, V9, P556, DOI 10.1016/j.cmet.2009.04.009
   Shamu CE, 1996, EMBO J, V15, P3028, DOI 10.1002/j.1460-2075.1996.tb00666.x
   Travers KJ, 2000, CELL, V101, P249, DOI 10.1016/S0092-8674(00)80835-1
   Welihinda AA, 1996, J BIOL CHEM, V271, P18181, DOI 10.1074/jbc.271.30.18181
   Woo CW, 2009, NAT CELL BIOL, V11, P1473, DOI 10.1038/ncb1996
   Yamamoto K, 2007, DEV CELL, V13, P365, DOI 10.1016/j.devcel.2007.07.018
   Yang L, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011621
   Zhang KZ, 2005, J CLIN INVEST, V115, P268, DOI 10.1172/JCI200521848
   Zhang W, 2006, CELL METAB, V4, P491, DOI 10.1016/j.cmet.2006.11.002
NR 24
TC 36
Z9 43
U1 0
U2 4
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0076-6879
BN 978-0-12-385114-7
J9 METHOD ENZYMOL
JI Methods Enzymol.
PY 2011
VL 490
BP 137
EP 146
DI 10.1016/B978-0-12-385114-7.00008-8
PG 10
WC Biochemical Research Methods; Biochemistry & Molecular Biology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA BTP02
UT WOS:000287674900008
PM 21266248
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Manhem, K
   Ahlm, H
   Dellborg, M
   Milsom, I
AF Manhem, K
   Ahlm, H
   Dellborg, M
   Milsom, I
TI Acute effects of transdermal estrogen in postmenopausal women with
   coronary artery disease - Using a clinically relevant estrogen dose and
   concurrent antianginal therapy
SO CARDIOLOGY
LA English
DT Article
DE coronary heart disease; postmenopausal women; estrogen
ID DENSITY-LIPOPROTEIN OXIDATION; REPLACEMENT THERAPY; HORMONE REPLACEMENT;
   MYOCARDIAL-ISCHEMIA; SYNDROME-X; ANGINA; PERFORMANCE; ESTRADIOL;
   CHANNELS
AB In the present study the acute anti-ischemic effect of clinically relevant doses of transdermal estradiol during concurrent antianginal therapy was investigated in 14 postmenopausal women with stable coronary artery disease, Plasma estradiol was significantly increased, but no significant effects on time to angina, time to 1 mm S-T depression, total exercise time, maximum rate-pressure product, maximum S-T depression or maximum workload were found, However, resting diastolic blood pressure was significantly decreased due to estrogen, Copyright (C) 2001 S. Karger AG, Basel .
C1 Sahlgrens Univ Hosp, Dept Med, Clin Expt Res Lab, Univ Gothenburg, S-41685 Gothenburg, Sweden.
   Sahlgrens Univ Hosp, Dept Obstet & Gynecol, Univ Gothenburg, S-41345 Gothenburg, Sweden.
C3 Sahlgrenska University Hospital; University of Gothenburg; University of
   Gothenburg; Sahlgrenska University Hospital
RP Manhem, K (corresponding author), Sahlgrens Univ Hosp, Dept Med, Clin Expt Res Lab, Univ Gothenburg, S-41685 Gothenburg, Sweden.
CR Al-Khalili F, 1998, EUR HEART J, V19, P1019, DOI 10.1053/euhj.1998.0975
   Albertsson PA, 1996, INT J CARDIOL, V54, P13, DOI 10.1016/0167-5273(96)02560-0
   Andersson B, 1997, J CLIN ENDOCR METAB, V82, P638, DOI 10.1210/jc.82.2.638
   BARRETTCONNOR E, 1992, ANNU REV MED, V43, P239, DOI 10.1146/annurev.med.43.1.239
   BUSH TL, 1990, ANN NY ACAD SCI, V592, P263
   BUSH TL, 1987, CIRCULATION, V75, P1102, DOI 10.1161/01.CIR.75.6.1102
   CHESTER AH, 1995, CORONARY ARTERY DIS, V6, P417, DOI 10.1097/00019501-199505000-00009
   HAN SZ, 1995, CIRCULATION, V91, P2619, DOI 10.1161/01.CIR.91.10.2619
   HERRINGTON DM, 1994, AM J CARDIOL, V73, P951, DOI 10.1016/0002-9149(94)90136-8
   Holdright DR, 1995, EUR HEART J, V16, P1566, DOI 10.1093/oxfordjournals.eurheartj.a060779
   Hulley S, 1998, JAMA-J AM MED ASSOC, V280, P605, DOI 10.1001/jama.280.7.605
   JIANG C, 1992, AM J PHYSIOL, V263, P271
   KEANEY JF, 1994, CIRCULATION, V89, P2251, DOI 10.1161/01.CIR.89.5.2251
   LEHTOVIRTA P, 1974, J OBSTET GYN BR COMM, V81, P517
   Lloyd GWL, 1998, INT J CLIN PRACT, V52, P155
   LUTOLA H, 1983, ANN CLIN RES S38, V15, P1
   MAGNESS RR, 1989, AM J PHYSIOL, V256, pE536, DOI 10.1152/ajpendo.1989.256.4.E536
   Manhem K, 1998, J HUM HYPERTENS, V12, P323, DOI 10.1038/sj.jhh.1000563
   MILLER VT, 1995, JAMA-J AM MED ASSOC, V273, P199, DOI 10.1001/jama.1995.03520270033028
   PROUDLER AJ, 1995, LANCET, V346, P89, DOI 10.1016/S0140-6736(95)92114-1
   Rajkumar C, 1997, J AM COLL CARDIOL, V30, P350, DOI 10.1016/S0735-1097(97)00191-5
   REIS SE, 1994, CIRCULATION, V89, P52, DOI 10.1161/01.CIR.89.1.52
   RIFICI VA, 1992, METABOLISM, V41, P1110, DOI 10.1016/0026-0495(92)90295-L
   Rosano GMC, 1996, J AM COLL CARDIOL, V28, P1500
   ROSANO GMC, 1993, LANCET, V342, P133, DOI 10.1016/0140-6736(93)91343-K
   Sbarouni E, 1997, AM J CARDIOL, V79, P87, DOI 10.1016/S0002-9149(96)00685-6
   STAMPFER MJ, 1991, NEW ENGL J MED, V325, P756, DOI 10.1056/NEJM199109123251102
   VOLTERRANI M, 1995, AM J MED, V99, P119, DOI 10.1016/S0002-9343(99)80130-2
   Webb CM, 1998, LANCET, V351, P1556, DOI 10.1016/S0140-6736(05)61121-X
   Wellman GC, 1996, CIRC RES, V79, P1024, DOI 10.1161/01.RES.79.5.1024
   WHITE RE, 1995, CIRC RES, V77, P936, DOI 10.1161/01.RES.77.5.936
NR 31
TC 0
Z9 0
U1 0
U2 0
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0008-6312
J9 CARDIOLOGY
JI Cardiology
PY 2000
VL 94
IS 2
BP 86
EP 90
DI 10.1159/000047297
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 395EU
UT WOS:000166567600003
PM 11173778
DA 2025-06-11
ER

PT J
AU Patel, S
   Pangarkar, A
   Mahajan, S
   Majumdar, A
AF Patel, Shivangi
   Pangarkar, Arnika
   Mahajan, Sakshi
   Majumdar, Anuradha
TI Therapeutic potential of endoplasmic reticulum stress inhibitors in the
   treatment of diabetic peripheral neuropathy
SO METABOLIC BRAIN DISEASE
LA English
DT Review
DE Unfolded Protein Response; Diabetic peripheral neuropathy (DPN);
   Hyperalgesia; Allodynia; ER stress inhibitors
ID PROTECTS PC12 CELLS; ER STRESS; CALCIUM HOMEOSTASIS; OXIDATIVE STRESS;
   MOUSE MODEL; BETA-CELLS; APOPTOSIS; INSULIN; DEATH; 4-PHENYLBUTYRATE
AB Endoplasmic stress response, the unfolded protein response (UPR), is a homeostatic signaling pathway comprising transmembrane sensors that get activated upon alterations in ER luminal environment. Studies suggest a relation between activated UPR pathways and several disease states such as Parkinson, Alzheimer, inflammatory bowel disease, tumor growth, and metabolic syndrome. Diabetic peripheral neuropathy (DPN), a common microvascular complication of diabetes-related chronic hyperglycemia, causes chronic pain, loss of sensation, foot ulcers, amputations, allodynia, hyperalgesia, paresthesia, and spontaneous pain. Factors like disrupted calcium signaling, dyslipidemia, hyperglycemia, inflammation, insulin signaling, and oxidative stress disturb the UPR sensor levels manifesting as DPN. We discuss new effective therapeutic alternatives for DPN that can be developed by targeting UPR pathways like synthetic ER stress inhibitors like 4-PhenylButyric acid (4-PBA), Sephin 1, Salubrinal and natural ER stress inhibitors like Tauroursodeoxycholic acid (TUDCA), Cordycepin, Proanthocyanidins, Crocin, Purple Rice extract and cyanidin and Caffeic Acid Phenethyl Ester (CAPE).
C1 [Patel, Shivangi; Pangarkar, Arnika; Mahajan, Sakshi; Majumdar, Anuradha] Bombay Coll Pharm, Dept Pharmacol, Mumbai 400098, India.
RP Majumdar, A (corresponding author), Bombay Coll Pharm, Dept Pharmacol, Mumbai 400098, India.
EM anuradha.majumdar@gmail.com
OI Patel, Shivangi/0009-0006-8529-6155; Mahajan, Sakshi/0009-0000-6179-2564
CR Adams CJ, 2019, FRONT MOL BIOSCI, V6, DOI 10.3389/fmolb.2019.00011
   Andreassi C, 2004, EUR J HUM GENET, V12, P59, DOI 10.1038/sj.ejhg.5201102
   Bek MF, 2006, AM J PATHOL, V168, P20, DOI 10.2353/ajpath.2006.040774
   Boden G, 2008, DIABETES, V57, P2438, DOI 10.2337/db08-0604
   Boyce M, 2005, SCIENCE, V307, P935, DOI 10.1126/science.1101902
   Brussee V, 2004, DIABETES, V53, P1824, DOI 10.2337/diabetes.53.7.1824
   Candeias E, 2018, MOL NEUROBIOL, V55, P4030, DOI 10.1007/s12035-017-0622-3
   Cao SS, 2013, EXPERT OPIN THER TAR, V17, P437, DOI 10.1517/14728222.2013.756471
   Celik S, 2009, PHARMACOL RES, V60, P270, DOI 10.1016/j.phrs.2009.03.017
   Cermenati G, 2012, J LIPID RES, V53, P300, DOI 10.1194/jlr.M021188
   Chen CH, 2019, INFLAMMOPHARMACOLOGY, V27, P713, DOI 10.1007/s10787-019-00604-6
   Chen WJ., 2012, INT J ENDOCRINOL, V18, P2012
   Chen YA, 2019, BRAIN, V142, P344, DOI 10.1093/brain/awy322
   Cho JA, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0110086
   Choi JH, 2010, EXP MOL MED, V42, P811, DOI 10.3858/emm.2010.42.12.084
   Das I, 2015, SCIENCE, V348, P239, DOI 10.1126/science.aaa4484
   Del Signore SJ, 2009, AMYOTROPH LATERAL SC, V10, P85, DOI 10.1080/17482960802226148
   Ding Y, 2014, J NUTR BIOCHEM, V25, P765, DOI 10.1016/j.jnutbio.2014.03.007
   Dong Y, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/160980
   Doyle KM, 2011, J CELL MOL MED, V15, P2025, DOI 10.1111/j.1582-4934.2011.01374.x
   DRUMMOND IAS, 1987, J BIOL CHEM, V262, P12801
   English AR, 2013, CSH PERSPECT BIOL, V5, DOI 10.1101/cshperspect.a013227
   Farshid AA, 2015, AVICENNA J PHYTOMEDI, V5, P469
   Ferdaoussi M, 2008, DIABETES, V57, P1205, DOI 10.2337/db07-1214
   Fonseca SG, 2012, NAT CELL BIOL, V14, P1105, DOI 10.1038/ncb2578
   Fowler MJ., 2008, CLIN DIABETES, V26, P77, DOI DOI 10.2337/DIACLIN.26.2.77
   Fujiwara M, 2013, J PHARMACOL SCI, V122, P71, DOI 10.1254/jphs.12194FP
   Gao B, 2013, ACTA PHARMACOL SIN, V34, P657, DOI 10.1038/aps.2013.34
   Gardian G, 2005, J BIOL CHEM, V280, P556, DOI 10.1074/jbc.M410210200
   Görlach A, 2006, ANTIOXID REDOX SIGN, V8, P1391, DOI 10.1089/ars.2006.8.1391
   Gregor MF, 2009, DIABETES, V58, P693, DOI 10.2337/db08-1220
   Gu YY., 2015, EVID-BASED COMPL ALT, V1, P2015
   Han J, 2016, J LIPID RES, V57, P1329, DOI 10.1194/jlr.R067595
   Harding HP, 1999, NATURE, V397, P271, DOI 10.1038/16729
   Hinder LM, 2012, J PERIPHER NERV SYST, V17, P10, DOI 10.1111/j.1529-8027.2012.00389.x
   Huang TJ, 2002, DIABETOLOGIA, V45, P560, DOI 10.1007/s00125-002-0785-x
   Huang XM, 2012, NEUROBIOL AGING, V33, DOI 10.1016/j.neurobiolaging.2011.10.007
   Inden M, 2007, J NEUROCHEM, V101, P1491, DOI 10.1111/j.1471-4159.2006.04440.x
   Jia J, 2013, NEUROCHEM INT, V62, P1072, DOI 10.1016/j.neuint.2013.04.001
   Jin ML, 2014, NEUROTOXICOLOGY, V41, P102, DOI 10.1016/j.neuro.2014.01.005
   Juster-Switlyk K., 2016, F1000 RES, V5, P738, DOI [10.12688/f1000research.7898.1, DOI 10.12688/F1000RESEARCH.7898.1]
   Kadowaki H, 2013, GENES-BASEL, V4, P306, DOI 10.3390/genes4030306
   Khalaf K, 2022, TRANSL NEURODEGENER, V11, DOI 10.1186/s40035-022-00307-z
   Kim B, 2011, ENDOCRINOLOGY, V152, P3638, DOI 10.1210/en.2011-0029
   Kim JS, 2014, J NEURAL TRANSM, V121, P1233, DOI 10.1007/s00702-014-1208-0
   Kostyuk E, 2001, DIABETOLOGIA, V44, P1302, DOI 10.1007/s001250100642
   Kubota K, 2006, J NEUROCHEM, V97, P1259, DOI 10.1111/j.1471-4159.2006.03782.x
   Laybutt DR, 2007, DIABETOLOGIA, V50, P752, DOI 10.1007/s00125-006-0590-z
   Li YH, 1997, J CELL BIOL, V139, P1317, DOI 10.1083/jcb.139.5.1317
   Li Z, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076172
   Lin CC, 2021, BIORXIV, P2021
   Liu CL, 2012, J GERIATR CARDIOL, V9, P258, DOI 10.3724/SP.J.1263.2012.02292
   Liu H, 2016, CAN J DIABETES, V40, P329, DOI 10.1016/j.jcjd.2016.02.001
   Liu WJ, 2011, BRIT J PHARMACOL, V164, P1410, DOI 10.1111/j.1476-5381.2011.01272.x
   Lupachyk S, 2013, EXP NEUROL, V247, P342, DOI 10.1016/j.expneurol.2012.11.001
   Lupachyk S, 2013, DIABETES, V62, P944, DOI 10.2337/db12-0716
   Malhotra JD, 2007, SEMIN CELL DEV BIOL, V18, P716, DOI 10.1016/j.semcdb.2007.09.003
   Mantuano E, 2011, J NEUROSCI, V31, P13376, DOI 10.1523/JNEUROSCI.2850-11.2011
   Mayer CM, 2010, ENDOCRINOLOGY, V151, P576, DOI 10.1210/en.2009-1122
   McCullough KD, 2001, MOL CELL BIOL, V21, P1249, DOI 10.1128/MCB.21.4.1249-1259.2001
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Olatunji OJ, 2016, BIOMED PHARMACOTHER, V81, P7, DOI 10.1016/j.biopha.2016.03.009
   Oyadomari S, 2002, J CLIN INVEST, V109, P525, DOI 10.1172/JCI200214550
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Padilla A, 2011, BRAIN RES, V1370, P64, DOI 10.1016/j.brainres.2010.11.013
   Pavitt GD, 2012, CSH PERSPECT BIOL, V4, DOI 10.1101/cshperspect.a012278
   Pérez-Arancibia R, 2018, EXPERT OPIN THER TAR, V22, P97, DOI 10.1080/14728222.2018.1420169
   Plitman E, 2014, EUR NEUROPSYCHOPHARM, V24, P1591, DOI 10.1016/j.euroneuro.2014.07.015
   Qi X, 2004, MOL PHARMACOL, V66, P899, DOI 10.1124/mol.104.001339
   SAEEDI P, 2019, DIABETES RES CLIN PR, V157, DOI [DOI 10.1016/J.DIABRES.2019.107843, 10.1016/j.diabres.2019, DOI 10.1016/J.DIABRES.2019]
   Shimoda H., 2015, J RICE RES, V3, P137, DOI DOI 10.4172/2375-4338.1000137
   Soliman E, 2019, LIFE SCI, V239, DOI 10.1016/j.lfs.2019.117047
   Song BB, 2008, J CLIN INVEST, V118, P3378, DOI 10.1172/JCI34587
   Sun J, 2021, BIOMED PHARMACOTHER, V142, DOI 10.1016/j.biopha.2021.111977
   Thummayot S, 2014, NEUROTOXICOLOGY, V45, P149, DOI 10.1016/j.neuro.2014.10.010
   Tuli HS, 2014, 3 BIOTECH, V4, P1, DOI 10.1007/s13205-013-0121-9
   Turan D, 2020, EUR J PHARMACOL, V883, DOI 10.1016/j.ejphar.2020.173342
   Vernon PJ, 2013, ANTIOXID REDOX SIGN, V18, P677, DOI 10.1089/ars.2012.4810
   Veves A, 2008, PAIN MED, V9, P660, DOI 10.1111/j.1526-4637.2007.00347.x
   Vincent AM, 2005, FASEB J, V19, P638, DOI 10.1096/fj.04-2513fje
   Vincent AM, 2004, ENDOCR REV, V25, P612, DOI 10.1210/er.2003-0019
   Vincent AM, 2009, J PERIPHER NERV SYST, V14, P257, DOI 10.1111/j.1529-8027.2009.00237.x
   Vincent AM, 2009, DIABETES, V58, P2376, DOI 10.2337/db09-0047
   Wang M, 2016, NATURE, V529, P326, DOI 10.1038/nature17041
   Wang YG, 2009, NATURE, V460, P534, DOI 10.1038/nature08111
   Wu CT, 2011, FREE RADICAL BIO MED, V51, P671, DOI 10.1016/j.freeradbiomed.2011.04.038
   Yap MKK, 2019, BASIC CLIN PHARMACOL, V124, P513, DOI 10.1111/bcpt.13169
   Ylitalo KR, 2011, DIABETES CARE, V34, P1642, DOI 10.2337/dc10-2150
   Zhang GF, 2015, NEUROCHEM INT, V89, P101, DOI 10.1016/j.neuint.2015.07.011
   Zherebitskaya E, 2012, ASN NEURO, V4, P1, DOI 10.1042/AN20110038
   Zhou F, 2017, J PAIN RES, V10, P653, DOI 10.2147/JPR.S125805
NR 91
TC 19
Z9 20
U1 3
U2 23
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0885-7490
EI 1573-7365
J9 METAB BRAIN DIS
JI Metab. Brain Dis.
PD AUG
PY 2023
VL 38
IS 6
BP 1841
EP 1856
DI 10.1007/s11011-023-01239-x
EA JUN 2023
PG 16
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA L6GJ0
UT WOS:001003198800001
PM 37289403
DA 2025-06-11
ER

PT J
AU Shimosawa, T
   Fujita, T
AF Shimosawa, T
   Fujita, T
TI Adrenomedullin as a potent antioxidative and antiatherosclerotic
   substance
SO DRUG NEWS & PERSPECTIVES
LA English
DT Article
ID NEWLY IDENTIFIED PEPTIDE; INSULIN-RESISTANCE; MICE LACKING; SECRETION;
   STRESS; GENE; ABNORMALITIES; RECEPTORS; PRESSURE; INJURY
AB Adrenomedullin was originally discovered as a vasodilative peptide, but recent studies have revealed its pleiotropic effects. Among these studies, the antioxidative properties of adrenomedullin were observed in adrenomedullin knockout mice. Through its antioxidative. effect, adrenomedullin can protect organs from damage induced by high blood pressure, ischemia and aging. This indicates that antioxidants that can inhibit reactive oxygen species production but do not have a scavenging effect could be a new effective therapeutic target for organ protection in hypertension as well as metabolic syndrome, in which higher oxidative stress plays a pivotal role. (c) 2005 Prous Science. All rights reserved.
C1 Univ Tokyo, Fac Med, Dept Internal Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
C3 University of Tokyo
RP Univ Tokyo, Fac Med, Dept Internal Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM fujita-dis@h.u-tokyo.ac.jp
RI Shimosawa, Tatsuo/A-2920-2015
CR Ando K, 1998, HYPERTENS RES-CLIN E, V21, P187, DOI 10.1291/hypres.21.187
   BLAINE EH, 1990, HYPERTENSION, V15, P2, DOI 10.1161/01.HYP.15.1.2
   BOYD FT, 1985, J BIOL CHEM, V260, P5880
   Caron KM, 2001, P NATL ACAD SCI USA, V98, P615, DOI 10.1073/pnas.021548898
   Chini EN, 1997, KIDNEY INT, V52, P917, DOI 10.1038/ki.1997.413
   Chun TH, 2000, J HYPERTENS, V18, P575, DOI 10.1097/00004872-200018050-00010
   COWLEY AWJ, 1982, VASOPRESSION CARDIOV
   DeLeo FR, 1996, J LEUKOCYTE BIOL, V60, P677, DOI 10.1002/jlb.60.6.677
   Dickinson CJ., 1991, Neurogenic hypertension : a synthesis and review
   FUJITA T, 1987, CIRCULATION, V75, P525, DOI 10.1161/01.CIR.75.3.525
   HALL JE, 1986, AM J PHYSIOL, V250, pF907, DOI 10.1152/ajprenal.1986.250.5.F907
   HIRATA Y, 1995, HYPERTENSION, V25, P790, DOI 10.1161/01.HYP.25.4.790
   HORIO T, 1995, CIRC RES, V77, P660, DOI 10.1161/01.RES.77.4.660
   IMAI T, 1995, ENDOCRINOLOGY, V136, P1544, DOI 10.1210/en.136.4.1544
   Ishigami A, 2002, AM J PATHOL, V161, P1273, DOI 10.1016/S0002-9440(10)64404-5
   ISHIYAMA Y, 1993, EUR J PHARMACOL, V241, P271, DOI 10.1016/0014-2999(93)90214-3
   ISHIZAKA Y, 1994, BIOCHEM BIOPH RES CO, V200, P642, DOI 10.1006/bbrc.1994.1496
   JOUGASAKI M, 1995, AM J PHYSIOL-RENAL, V268, pF657, DOI 10.1152/ajprenal.1995.268.4.F657
   Jougasaki M, 1996, J CLIN INVEST, V97, P2370, DOI 10.1172/JCI118680
   Kano H, 1996, J HYPERTENS, V14, P209, DOI 10.1097/00004872-199602000-00009
   Kawai J, 2004, CIRCULATION, V109, P1147, DOI 10.1161/01.CIR.0000117231.40057.6D
   KITAMURA K, 1993, BIOCHEM BIOPH RES CO, V194, P720, DOI 10.1006/bbrc.1993.1881
   KOHNO M, 1995, HYPERTENSION, V25, P1185, DOI 10.1161/01.HYP.25.6.1185
   KUREISHI Y, 1995, BIOCHEM BIOPH RES CO, V212, P572, DOI 10.1006/bbrc.1995.2008
   MAHOMED FA, 1874, T MED CHIRURG SOC, V55, P197
   MAREY EJ, 1875, PRESSION VITESSE SAN
   MARSDEN PA, 1990, MECH ANGIOTENSIN ACT
   Martinez A, 1996, CELL TISSUE RES, V283, P169, DOI 10.1007/s004410050526
   Matsui H, 2004, CIRCULATION, V109, P2246, DOI 10.1161/01.CIR.0000127950.13380.FD
   MINAMINO N, 1995, BIOCHEM BIOPH RES CO, V211, P686, DOI 10.1006/bbrc.1995.1866
   MURPHY TC, 1995, ENDOCRINOLOGY, V136, P2459, DOI 10.1210/en.136.6.2459
   Nagaya N, 2004, CIRCULATION, V109, P351, DOI 10.1161/01.CIR.0000109493.05849.14
   Noiri E, 2001, AM J PHYSIOL-RENAL, V281, pF948, DOI 10.1152/ajprenal.0071.2001
   NUKI C, 1993, BIOCHEM BIOPH RES CO, V196, P245, DOI 10.1006/bbrc.1993.2241
   Pernow J, 1988, Acta Physiol Scand Suppl, V568, P1
   Riva-Rocci S., 1896, Gazz Med Torino, V47, P981
   SAID SI, 1983, HYPERTENSION, V5, pI17, DOI 10.1161/01.HYP.5.2_Pt_2.I17
   SHIMEKAKE Y, 1995, J BIOL CHEM, V270, P4412, DOI 10.1074/jbc.270.9.4412
   SHIMOKUBO T, 1995, LIFE SCI, V57, P1771, DOI 10.1016/0024-3205(95)02155-C
   Shimosawa T, 2003, HYPERTENS RES, V26, pS109, DOI 10.1291/hypres.26.S109
   Shimosawa T, 2003, HYPERTENSION, V41, P1080, DOI 10.1161/01.HYP.0000066846.46422.2C
   Shimosawa T, 1997, HYPERTENSION, V30, P1009, DOI 10.1161/01.HYP.30.5.1009
   SHIMOSAWA T, 1995, J CLIN INVEST, V96, P1672, DOI 10.1172/JCI118208
   Shimosawa T, 1996, HYPERTENSION, V28, P325, DOI 10.1161/01.HYP.28.3.325
   Shindo T, 2001, CIRCULATION, V104, P1964, DOI 10.1161/hc4101.097111
   SUGO S, 1994, BIOCHEM BIOPH RES CO, V201, P1160, DOI 10.1006/bbrc.1994.1827
   Takano K, 1996, J CLIN INVEST, V98, P14, DOI 10.1172/JCI118758
   Tigerstedt R., 1898, SCAND ARCH PHYSL, V8, P223
   von Basch S, 1880, Z KLIN MED, V2, P79
   WANG XK, 1995, P NATL ACAD SCI USA, V92, P11480, DOI 10.1073/pnas.92.25.11480
   Xing GQ, 2004, ENDOCRINOLOGY, V145, P3647, DOI 10.1210/en.2004-0027
   YAMAGUCHI T, 1994, LIFE SCI, V56, P379, DOI 10.1016/0024-3205(94)00903-1
   YANAGISAWA M, 1988, NATURE, V332, P411, DOI 10.1038/332411a0
   Yoshimoto T, 2004, ENDOCRINOLOGY, V145, P3331, DOI 10.1210/en.2003-1583
NR 54
TC 18
Z9 21
U1 0
U2 1
PU PROUS SCIENCE, SAU-THOMSON REUTERS
PI BARCELONA
PA 398 PROVENCA, 08025 BARCELONA, SPAIN
SN 0214-0934
EI 2013-0139
J9 DRUG NEWS PERSPECT
JI Drug News Perspect.
PD APR
PY 2005
VL 18
IS 3
BP 185
EP 189
DI 10.1358/dnp.2005.18.3.892764
PG 5
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 928AQ
UT WOS:000229243900006
PM 15915220
DA 2025-06-11
ER

PT J
AU Jeon, SW
   Chang, Y
   Lim, SW
   Cho, J
   Kim, HN
   Kim, KB
   Kim, J
   Kim, YH
   Shin, DW
   Oh, KS
   Shin, YC
   Ryu, S
AF Jeon, Sang Won
   Chang, Yoosoo
   Lim, Se-Won
   Cho, Juhee
   Kim, Han-Na
   Kim, Kyoung-Beom
   Kim, Jinseok
   Kim, Young Hwan
   Shin, Dong-Won
   Oh, Kang-Seob
   Shin, Young-Chul
   Ryu, Seungho
TI Bidirectional association between blood pressure and depressive symptoms
   in young and middle-age adults: A cohort study
SO EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
LA English
DT Article
DE Bidirectional association; blood pressure; cohort study; depression;
   depressive symptoms; hypertension; hypotension
ID EPIDEMIOLOGIC CATCHMENT-AREA; CES-D SCALE; METABOLIC SYNDROME;
   NEUROPEPTIDE-Y; HYPERTENSION INCIDENCE; ANXIETY; RISK; PATHOPHYSIOLOGY;
   METAANALYSIS; HYPOTHESIS
AB Aims To evaluate the bidirectional relationship between blood pressure (BP) and depressive symptoms using a large prospective cohort study. Methods Prospective cohort study was performed in 276 244 adults who participated in a regular health check-up and were followed annually or biennially for up to 5.9 years. BP levels were categorised according to the 2017 American College of Cardiology and American Heart Association hypertension guidelines. Depressive symptoms were assessed using Centre for Epidemiologic Studies-Depression (CESD) questionnaire and a cut-off score of >= 25 was regarded as case-level depressive symptoms. Results During 672 603.3 person-years of follow-up, 5222 participants developed case-level depressive symptoms. The multivariable-adjusted hazard ratios (HRs) [95% confidence interval (CI)] for incident case-level depressive symptoms comparing hypotension, elevated BP, hypertension stage 1 and hypertension stage 2 to normal BP were 1.07 (0.99-1.16), 0.93 (0.82-1.05), 0.89 (0.81-0.97) and 0.81 (0.62-1.06), respectively (pfor trend <0.001). During 583 615.3 person-years of follow-up, 27 787 participants developed hypertension. The multivariable-adjusted HRs (95% CI) for incident hypertension comparing CESD 16-24 and > 25 to CESD < 16 were 1.05 (1.01-1.11) and 1.12 (1.03-1.20), respectively (pfor trend <0.001) and in the time-dependent models, corresponding HRs (95% CI) were 1.12 (1.02-1.24) and 1.29 (1.10-1.50), respectively (pfor trend <0.001). Conclusions In this large cohort study of young and middle-aged individuals, higher BP levels were independently associated with a decreased risk for developing case-level depressive symptoms and depressive symptoms were also associated with incident hypertension. Further studies are required to elucidate the mechanisms underlying the bidirectional association between BP levels and incident depression.
C1 [Jeon, Sang Won; Lim, Se-Won; Shin, Dong-Won; Oh, Kang-Seob; Shin, Young-Chul] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Psychiat, Sch Med, Seoul, South Korea.
   [Chang, Yoosoo; Cho, Juhee; Kim, Kyoung-Beom; Ryu, Seungho] Kangbuk Samsung Hosp, Ctr Cohort Study, Total Healthcare Ctr, Seoul, South Korea.
   [Chang, Yoosoo; Ryu, Seungho] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Occupat & Environm Med, Sch Med, Seoul, South Korea.
   [Chang, Yoosoo; Cho, Juhee; Kim, Han-Na; Ryu, Seungho] Sungkyunkwan Univ, Dept Clin Res Design & Evaluat, SAIHST, Seoul, South Korea.
   [Lim, Se-Won; Shin, Young-Chul] Kangbuk Samsung Hosp, Workpl Mental Hlth Inst, Seoul, South Korea.
   [Kim, Han-Na] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Med Res Inst, Sch Med, Seoul, South Korea.
   [Kim, Jinseok] Seoul Womens Univ, Dept Social Welf, Seoul, South Korea.
   [Kim, Young Hwan] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Nucl Med, Sch Med, Seoul, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Sungkyunkwan
   University (SKKU); Samsung Medical Center; Sungkyunkwan University
   (SKKU); Samsung Medical Center; Sungkyunkwan University (SKKU);
   Sungkyunkwan University (SKKU); Samsung Medical Center; Sungkyunkwan
   University (SKKU); Samsung Medical Center; Seoul Women's University;
   Sungkyunkwan University (SKKU); Samsung Medical Center
RP Ryu, S (corresponding author), Kangbuk Samsung Hosp, Ctr Cohort Study, Total Healthcare Ctr, Seoul, South Korea.; Ryu, S (corresponding author), Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Occupat & Environm Med, Sch Med, Seoul, South Korea.; Ryu, S (corresponding author), Sungkyunkwan Univ, Dept Clin Res Design & Evaluat, SAIHST, Seoul, South Korea.
EM sh703.yoo@gmail.com
RI Kim, Kisook/GQB-2543-2022; Kim, Sunuk/KJM-5211-2024; Shin,
   Dong/F-5366-2010; Cho, Juhee/ABD-2280-2021
OI Chang, Yoosoo/0000-0002-6945-9050; Ryu, Seungho/0000-0002-3927-8646
FU Byung-yoon Lee Scholarship Association
FX We dedicate this paper to the spirit of the departed, Professor Se-Won
   Lim. This research was supported by the Byung-yoon Lee Scholarship
   Association.
CR Akbaraly TN, 2009, DIABETES CARE, V32, P499, DOI 10.2337/dc08-1358
   [Anonymous], 2018, MED BALTIMORE, V97, pe9654
   Chang Y, 2016, ANN INTERN MED, V165, P744, DOI 10.7326/L16-0405
   Cho MJ, 2015, PSYCHIAT INVEST, V12, P164, DOI 10.4306/pi.2015.12.2.164
   Cho MJ, 1998, J NERV MENT DIS, V186, P304, DOI 10.1097/00005053-199805000-00007
   Chun MY, 2012, KOREAN J FAM MED, V33, P144, DOI 10.4082/kjfm.2012.33.3.144
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   Davidson K, 2000, ARCH INTERN MED, V160, P1495, DOI 10.1001/archinte.160.10.1495
   Dayan CM, 2013, EUR THYROID J, V2, P168, DOI 10.1159/000353777
   Duffy B.E., 2010, COMMUNICATION CULTUR, V3, P26, DOI DOI 10.1111/J.1753-9137.2009.01056.X
   Fiske A, 2009, ANNU REV CLIN PSYCHO, V5, P363, DOI 10.1146/annurev.clinpsy.032408.153621
   Hallas J, 1996, EPIDEMIOLOGY, V7, P478, DOI 10.1097/00001648-199609000-00005
   Hammerton G, 2013, BMJ OPEN, V3, DOI 10.1136/bmjopen-2013-003206
   Hashimoto H, 1996, NEUROSCI LETT, V216, P57
   Heilig M, 2004, NEUROPEPTIDES, V38, P213, DOI 10.1016/j.npep.2004.05.002
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Hildrum B, 2008, BRIT J PSYCHIAT, V193, P108, DOI 10.1192/bjp.bp.107.045013
   Hildrum B, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-601
   Hiles SA, 2016, DEPRESS ANXIETY, V33, P754, DOI 10.1002/da.22512
   Jonas BS, 1997, ARCH FAM MED, V6, P43, DOI 10.1001/archfami.6.1.43
   JonesWebb R, 1996, ALCOHOL CLIN EXP RES, V20, P420, DOI 10.1111/j.1530-0277.1996.tb01069.x
   Jorm AF, 2000, PSYCHOL MED, V30, P11, DOI 10.1017/S0033291799001452
   Karl T, 2007, PEPTIDES, V28, P326, DOI 10.1016/j.peptides.2006.07.027
   Lambert PC, 2009, STATA J, V9, P265, DOI 10.1177/1536867X0900900206
   Lewington S, 2002, LANCET, V360, P1903, DOI 10.1016/S0140-6736(02)11911-8
   LIGHT KC, 1983, SCIENCE, V220, P429, DOI 10.1126/science.6836285
   MCDERMOTT BJ, 1993, CARDIOVASC RES, V27, P893, DOI 10.1093/cvr/27.6.893
   Meng L, 2012, J HYPERTENS, V30, P842, DOI 10.1097/HJH.0b013e32835080b7
   Meyer CM, 2004, J AFFECT DISORDERS, V83, P127, DOI 10.1016/j.jad.2004.06.004
   Michalkiewicz M, 2003, HYPERTENSION, V41, P1056, DOI 10.1161/01.HYP.0000066623.64368.4E
   Nabi H, 2011, HYPERTENSION, V57, P710, DOI 10.1161/HYPERTENSIONAHA.110.164061
   Organization W.H., 2017, Depression and other common mental disorders: Global health estimates
   Paterniti S, 2000, BRIT J PSYCHIAT, V176, P464, DOI 10.1192/bjp.176.5.464
   PATTEN SB, 1990, CAN J PSYCHIAT, V35, P257, DOI 10.1177/070674379003500312
   PILGRIM JA, 1992, BRIT MED J, V304, P75, DOI 10.1136/bmj.304.6819.75
   Pulkki-Råback L, 2009, HEALTH PSYCHOL, V28, P108, DOI 10.1037/a0012646
   Rathmann W, 1999, J CLIN EPIDEMIOL, V52, P1103, DOI 10.1016/S0895-4356(99)00082-7
   Reboussin DM, 2018, HYPERTENSION, V71, pE116, DOI [10.1161/HYP.0000000000000067, 10.1016/j.jacc.2017.11.004]
   Ressler KJ, 1999, BIOL PSYCHIAT, V46, P1219, DOI 10.1016/S0006-3223(99)00127-4
   Ressler KJ, 2000, DEPRESS ANXIETY, V12, P2, DOI 10.1002/1520-6394(2000)12:1+<2::AID-DA2>3.3.CO;2-W
   ROBERTS RE, 1990, PSYCHIAT RES, V31, P69, DOI 10.1016/0165-1781(90)90110-Q
   Royston P, 2002, STAT MED, V21, P2175, DOI 10.1002/sim.1203
   Scherrer JF, 2003, PSYCHOSOM MED, V65, P548, DOI 10.1097/01.PSY.0000077507.29863.CB
   SIEVER LJ, 1985, AM J PSYCHIAT, V142, P1017
   Solomon DA, 2000, AM J PSYCHIAT, V157, P229, DOI 10.1176/appi.ajp.157.2.229
   Son BK, 1997, AM J EPIDEMIOL, V145, P110
   Stahl SM, 2000, J CLIN PSYCHIAT, V61, P77, DOI 10.4088/JCP.v61n0201
   Takeuchi T, 2009, DIABETES-METAB RES, V25, P762, DOI 10.1002/dmrr.1041
   Toker S, 2008, DEPRESS ANXIETY, V25, P661, DOI 10.1002/da.20379
   Watts SW, 2012, PHARMACOL REV, V64, P359, DOI 10.1124/pr.111.004697
   WESSELY S, 1990, BMJ-BRIT MED J, V301, P362, DOI 10.1136/bmj.301.6748.362
NR 51
TC 25
Z9 27
U1 0
U2 3
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2045-7960
EI 2045-7979
J9 EPIDEMIOL PSYCH SCI
JI Epidemiol. Psychiatr. Sci.
PY 2020
VL 29
AR e142
DI 10.1017/S2045796020000542
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA MK1HQ
UT WOS:000548537800001
PM 32665058
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Stankovic, Z
   Jasovic-Gasic, M
   Zamaklar, M
AF Stankovic, Zana
   Jasovic-Gasic, Miroslava
   Zamaklar, Miroslava
TI PSYCHO-SOCIAL AND CLINICAL VARIABLES ASSOCIATED WITH DEPRESSION IN
   PATIENTS WITH TYPE 2 DIABETES
SO PSYCHIATRIA DANUBINA
LA English
DT Article
DE depression; type 2 diabetes; comorbidity; risk factors; neuropathy;
   diabetes related distress
ID QUALITY-OF-LIFE; CO-MORBID DEPRESSION; GLYCEMIC CONTROL; METABOLIC
   SYNDROME; EUROPEAN DEPRESSION; COMORBID DEPRESSION; SYMPTOMS;
   PREVALENCE; DISORDERS; RISK
AB Background: Type 2 diabetes (T2DM,) doubles the odds of comorbid depression. Depression is a strong predictor of developing T2DM The aim of the study was to compare depressed patients with T2DM to non-depressed ones with respect to demographic, psycho-social, clinical, anthropometric and metabolic characteristics; to examine the relationship between glycemic control and depression severity in depressed patients; to estimate the risk factors of depression.
   Subjects and Methods: A group of depressed diabetic patients comprising those with a Major depressive episode, first or repeated (ICD-10; 1992) and endocrinologist-diagnosed T2DM, duration >= 5 years on oral, insulin therapy or both (N=46) and non-depressed ones (N=44) (90 in total) of both genders (< 65 years) were included in this cross-sectional study. Laboratory and non-laboratory measures were performed.. The patient Health Questionnaire (PHQ-9) and a structured interview (MINI) were used to establish diagnosis, while the Beck Depression Inventory (BDI; cut off >= 16) was used to assess the severity of depression. Scaling of Life Events (SLE) for self-assessment of life events and Problem in Areas in Diabetes (PAID) for self-assessment of diabetes distress were also performed.
   Results: Statistically significant higher rates of psychiatric heredity, neuropathy, higher level of diabetes related distress and a greater number of life events in depressed patients compared to non-depressed ones were found There was a statistically significant positive correlation between BDI somatic subscore and the HbAlc level (r=0.343; p=0.020). The level of diabetes related distress (OR=1.084; p=0.000), total number of life events (OR=4.528; p=0.001) and neuropathy (OR=8.699; p=0.039) were statistically significant predictors of depression using logistic regression.
   Conclusions: The results obtained showed that depression in diabetic patients was predicted by both psychological (diabetes related distress, life events) and disease-specific variables (neuropathy). The severity of self-reported somatic depressive symptoms significantly correlated with the HbAlc level in depressed diabetic patients.
C1 [Stankovic, Zana; Jasovic-Gasic, Miroslava] Univ Belgrade, Psychiat Clin, Clin Ctr Serbia, Belgrade 11000, Serbia.
   [Zamaklar, Miroslava] Univ Belgrade, Inst Endocrinol Diabet & Dis Metab, Belgrade 11000, Serbia.
   [Jasovic-Gasic, Miroslava; Zamaklar, Miroslava] Univ Belgrade, Sch Med, Belgrade 11000, Serbia.
C3 University of Belgrade; Clinical Centre of Serbia; University of
   Belgrade; University of Belgrade
RP Stankovic, Z (corresponding author), Univ Belgrade, Psychiat Clin, Clin Ctr Serbia, Pasterova 2, Belgrade 11000, Serbia.
EM stankovic.zana@gmail.com
CR Abrahamian H, 2009, NEUROPSYCH DIS TREAT, V5, P261
   Agbir TM, 2010, ANN AFR MED, V9, P5, DOI 10.4103/1596-3519.62617
   Aikens JE, 2008, DIABETIC MED, V25, P1324, DOI 10.1111/j.1464-5491.2008.02590.x
   Ali S, 2006, DIABETIC MED, V23, P1165, DOI 10.1111/j.1464-5491.2006.01943.x
   Almawi W, 2008, J ENDOCRINOL INVEST, V31, P1020, DOI 10.1007/BF03345642
   Alonso J, 2004, ACTA PSYCHIAT SCAND, V109, P21
   *AM DIAB ASS, 2003, DIABETES CARE, V1, P94
   Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   [Anonymous], 2017, The World Health Report 2017. Leishmaniose. In
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   BHALLA RN, 2010, DEPRESSION
   Boulton AJM, 2004, DIABETES CARE, V27, P1458, DOI 10.2337/diacare.27.6.1458
   Brown LC, 2005, DIABETES CARE, V28, P1063, DOI 10.2337/diacare.28.5.1063
   BROWN LC, 2006, CMAJ, V175
   Collins MM, 2009, DIABETIC MED, V26, P153, DOI 10.1111/j.1464-5491.2008.02648.x
   Cosgrove MP, 2008, OCCUP MED-OXFORD, V58, P7, DOI 10.1093/occmed/kqm105
   Daly JM, 2009, J AM BOARD FAM MED, V22, P280, DOI 10.3122/jabfm.2009.03.080114
   de Groot M, 2001, PSYCHOSOM MED, V63, P619, DOI 10.1097/00006842-200107000-00015
   Després JP, 2008, ARTERIOSCL THROM VAS, V28, P1039, DOI 10.1161/ATVBAHA.107.159228
   Egede LE, 2005, PSYCHOSOM MED, V67, P46, DOI 10.1097/01.psy.0000149260.82006.fb
   Egede LE, 2010, DIABETES TECHNOL THE, V12, P257, DOI 10.1089/dia.2009.0143
   Filipcic I, 2010, PSYCHIAT DANUB, V22, P231
   Fisher L, 2008, DIABETIC MED, V25, P1096, DOI 10.1111/j.1464-5491.2008.02533.x
   Fisher L, 2001, DIABETES CARE, V24, P1751, DOI 10.2337/diacare.24.10.1751
   Fisher L, 2007, DIABETES CARE, V30, P542, DOI 10.2337/dc06-1614
   Fisher L, 2010, DIABETES CARE, V33, P23, DOI 10.2337/dc09-1238
   FOLSTEIN M, 1999, J PSYCHIATR RES, V12, P189
   Gavin JR, 1999, DIABETES CARE, V22, pS5
   Georgiades A, 2007, PSYCHOSOM MED, V69, P235, DOI 10.1097/PSY.0b013e318042588d
   Golden SH, 2008, JAMA-J AM MED ASSOC, V299, P2751, DOI 10.1001/jama.299.23.2751
   Gonzalez JS, 2008, DIABETOLOGIA, V51, P1822, DOI 10.1007/s00125-008-1113-x
   Halbreich U, 2007, J AFFECT DISORDERS, V102, P159, DOI 10.1016/j.jad.2006.09.033
   Heckbert SR, 2010, J GEN INTERN MED, V25, P524, DOI 10.1007/s11606-010-1272-6
   INGRAM RE, 1984, COGNITIVE THER RES, V8, P443, DOI 10.1007/BF01173284
   Jakovjevic M, 2007, PSYCHIAT DANUB, V19, P76
   Katon WJ, 2004, J GEN INTERN MED, V19, P1192, DOI 10.1111/j.1525-1497.2004.30405.x
   Kawakami N, 1999, DIABETES CARE, V22, P1071, DOI 10.2337/diacare.22.7.1071
   Knol MJ, 2006, DIABETOLOGIA, V49, P837, DOI 10.1007/s00125-006-0159-x
   Kokoszka A, 2009, EUR PSYCHIAT, V24, P425, DOI 10.1016/j.eurpsy.2009.04.002
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178, DOI 10.4088/JCP.v69n0202
   Lecrubier Y, 1997, EUR PSYCHIAT, V12, P224, DOI 10.1016/S0924-9338(97)83296-8
   Lee HJ, 2009, J AM ACAD NURSE PRAC, V21, P214, DOI 10.1111/j.1745-7599.2009.00396.x
   Lin EHB, 2010, DIABETES CARE, V33, P264, DOI 10.2337/dc09-1068
   Lustman PJ, 2007, DIABETES CARE, V30, P459, DOI 10.2337/dc06-1769
   Lustman PJ, 1997, PSYCHOSOM MED, V59, P241, DOI 10.1097/00006842-199705000-00007
   Lustman PJ, 2005, J DIABETES COMPLICAT, V19, P113, DOI 10.1016/j.jdiacomp.2004.01.002
   Lustman PJ, 2000, DIABETES CARE, V23, P934, DOI 10.2337/diacare.23.7.934
   LUSTMAN PJ, 2004, DIABETES SPECTRUM, P160
   McIntyre RS, 2006, EXPERT OPIN DRUG SAF, V5, P157, DOI 10.1517/14740338.5.1.157
   Mezuk B, 2008, AM J PUBLIC HEALTH, V98, P1480, DOI 10.2105/AJPH.2007.126441
   Miyaoka Y, 1997, PSYCHIAT CLIN NEUROS, V51, P203, DOI 10.1111/j.1440-1819.1997.tb02583.x
   Moreira RO, 2007, BRAZ J MED BIOL RES, V40, P269, DOI 10.1590/S0100-879X2006005000051
   Musselman DL, 2003, BIOL PSYCHIAT, V54, P317, DOI 10.1016/S0006-3223(03)00569-9
   National Institutes of Health (NIH), 2001, NIH PUBL
   Paola LD, 2006, CURR DIABETES REV, V2, P431, DOI 10.2174/1573399810602040431
   PAYKEL ES, 1971, ARCH GEN PSYCHIAT, V25, P340, DOI 10.1001/archpsyc.1971.01750160052010
   Pibernik-Okanovic M, 2008, J DIABETES COMPLICAT, V22, P246, DOI 10.1016/j.jdiacomp.2007.03.002
   POLONSKY WH, 1995, DIABETES CARE, V18, P754, DOI 10.2337/diacare.18.6.754
   Pouwer F, 2005, DIABETES RES CLIN PR, V70, P166, DOI 10.1016/j.diabres.2005.03.031
   Pouwer F, 2001, DIABETIC MED, V18, P595, DOI 10.1046/j.1464-5491.2001.00499.x
   Räikkönen K, 2007, DIABETES CARE, V30, P872, DOI 10.2337/dc06-1857
   Spitzer RL, 1999, JAMA-J AM MED ASSOC, V282, P1737, DOI 10.1001/jama.282.18.1737
   Üstün TB, 2004, BRIT J PSYCHIAT, V184, P386, DOI 10.1192/bjp.184.5.386
   van Bastelaar KMP, 2010, DIABETIC MED, V27, P798, DOI 10.1111/j.1464-5491.2010.03025.x
   Van Tilburg MAL, 2001, PSYCHOSOM MED, V63, P551, DOI 10.1097/00006842-200107000-00005
   WALLENTIN L, 2004, J AM COLL CARDIOL, V43, P585
   Wild S, 2004, DIABETES CARE, V27, P1047, DOI 10.2337/diacare.27.5.1047
   World Health Organization, 1992, International Statistical Classification of Diseases and Related Health Problems, V10
   Yoshida S, 2009, PSYCHIAT CLIN NEUROS, V63, P65, DOI 10.1111/j.1440-1819.2008.01889.x
   ZIMMERMAN M, 1986, J HUM STRESS, V12, P13, DOI 10.1080/0097840X.1986.9936761
NR 70
TC 13
Z9 16
U1 0
U2 8
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PD MAR
PY 2011
VL 23
IS 1
BP 34
EP 44
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 752OT
UT WOS:000289702700005
PM 21448095
DA 2025-06-11
ER

PT J
AU Speer, KE
   Naumovski, N
   McKune, A
AF Speer, Kathryn E.
   Naumovski, Nenad
   McKune, Andrew
TI Heart rate variability to track autonomic nervous system health in young
   children: Effects of physical activity and cardiometabolic risk factors
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Autonomic nervous system or ANS; Heart rate variability or HRV; Physical
   activity; Children; Cardiometabolic disease
ID CARDIORESPIRATORY FITNESS; VAGAL REGULATION; INFANT DIET; EXERCISE;
   STRESS; INTERVENTION; BIOFEEDBACK; OVERWEIGHT; ADOLESCENT; ADIPOSITY
AB Evidence for a key role of dysregulated autonomic nervous system (ANS) activity in maladaptive stress response/recovery and non-communicable disease development is extensive. Monitoring ANS activity via regular heart rate variability (HRV) measurement is growing in popularity in adult populations given that low HRV has been associated with ANS dysregulation, poor stress response/reactivity, increased cardiometabolic disease risk and early mortality. Although cardiometabolic disease may originate in early life, regular HRV measurement for assessing ANS activity in childhood populations, especially those consisting of children < 6 years of age, remains largely unpractised. A greater understanding of ANS activity modifiers in early life may improve analysis and interpretation of HRV measurements, thereby optimising its usefulness. Taking into consideration that HRV and ANS activity can be improved via daily engagement in physical activity (PA), this review will discuss the ANS and HRV, ANS activity modifiers, cardiometabolic disease risk factors and PA as they relate to childhood/adolescent populations (<= 18 years old).
C1 [Speer, Kathryn E.; Naumovski, Nenad; McKune, Andrew] Univ Canberra, Fac Hlth, 11 Kirinari St, Bruce, ACT 2617, Australia.
   [Speer, Kathryn E.; Naumovski, Nenad; McKune, Andrew] Univ Canberra, Funct Foods & Nutr Res FFNR Lab, 11 Kirinari St, Bruce, ACT 2617, Australia.
   [Speer, Kathryn E.; Naumovski, Nenad; McKune, Andrew] Univ Canberra, Res Inst Sport & Exercise, 11 Kirinari St, Bruce 2617, Australia.
   [McKune, Andrew] Univ KwaZulu Natal, Sch Hlth Sci, Discipline Biokinet Exercise & Leisure Sci, ZA-4000 Durban, Kwazulu Natal, South Africa.
   [Naumovski, Nenad] Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens 17671, Greece.
   [Speer, Kathryn E.] 11 Kirinari St, Bruce 2617, Australia.
C3 University of Canberra; University of Canberra; University of Canberra;
   University of Kwazulu Natal; Harokopio University Athens
RP Speer, KE (corresponding author), 11 Kirinari St, Bruce 2617, Australia.
EM katie.speer@canberra.edu.au
RI McKune, Andrew/AAM-3086-2020; Naumovski, Nenad/O-5617-2015
FU Hospital Research Foundation [2019/054-83100]
FX This article did not receive any specific grant from funding agencies in
   the public, commercial, or not -for-profit sectors. AJM's and NN's
   research on children and the autonomic nervous system is funded by The
   Hospital Research Foundation, Grant ID: 2019/054-83100.
CR Abhishekh HA, 2013, J CLIN MONIT COMPUT, V27, P259, DOI 10.1007/s10877-012-9424-3
   Aritzeta A, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19095475
   Beetham KS, 2019, BMC PREGNANCY CHILDB, V19, DOI 10.1186/s12884-019-2441-1
   Bianchi AM, 2010, IEEE T INF TECHNOL B, V14, P741, DOI 10.1109/TITB.2010.2049025
   Billeci L, 2019, SENSORS-BASEL, V19, DOI 10.3390/s19122820
   Bond B, 2015, AM J PHYSIOL-HEART C, V309, pH1039, DOI 10.1152/ajpheart.00360.2015
   Buchhorn R, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0166447
   Barreto GSC, 2016, J PEDIAT-BRAZIL, V92, P638
   Chiang JJ, 2015, DEV PSYCHOBIOL, V57, P887, DOI 10.1002/dev.21329
   da Silva SG, 2015, EXPERT REV NEUROTHER, V15, P1041, DOI 10.1586/14737175.2015.1077115
   Davis CL, 2011, HEALTH PSYCHOL, V30, P91, DOI 10.1037/a0021766
   Dhabhar FS, 2014, IMMUNOL RES, V58, P193, DOI 10.1007/s12026-014-8517-0
   Dormal V, 2021, J CHILD PSYCHOL PSYC, V62, P1379, DOI 10.1111/jcpp.13463
   Farinatti P, 2016, PEDIATR EXERC SCI, V28, P374, DOI 10.1123/pes.2015-0191
   Faulkner MS, 2019, J CARDIOVASC NURS, V34, P372, DOI 10.1097/JCN.0000000000000590
   Finlay-Jones A, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2020-046078
   Forte G, 2019, FRONT NEUROSCI-SWITZ, V13, DOI 10.3389/fnins.2019.00710
   Gába A, 2020, BMC PEDIATR, V20, DOI 10.1186/s12887-020-02036-6
   Gerardo GM, 2019, AM J HUM BIOL, V31, DOI 10.1002/ajhb.23208
   Gutin B, 2000, OBES RES, V8, P12, DOI 10.1038/oby.2000.3
   Hofstee P, 2018, CLIN EXP PHARMACOL P, V45, P871, DOI 10.1111/1440-1681.12954
   Morgan SJ, 2017, APPL PSYCHOPHYS BIOF, V42, P235, DOI 10.1007/s10484-017-9364-2
   Johnson M, 2017, INT J PSYCHOPHYSIOL, V116, P45, DOI 10.1016/j.ijpsycho.2017.02.010
   Johnston BW, 2020, J INTENSIVE CARE SOC, V21, P148, DOI 10.1177/1751143719853744
   Kaplan Deanna M, 2023, Mayo Clin Proc Digit Health, V1, P413, DOI 10.1016/j.mcpdig.2023.06.014
   Kemp AH, 2017, NEUROSCI BIOBEHAV R, V83, P547, DOI 10.1016/j.neubiorev.2017.09.006
   Khan NA, 2014, PEDIATR EXERC SCI, V26, P138, DOI 10.1123/pes.2013-0125
   Khodadadi Fateme, 2021, Int J Crit Illn Inj Sci, V11, P134, DOI 10.4103/IJCIIS.IJCIIS_196_20
   Kloter E, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00623
   Klugman J, 2011, J ECON INEQUAL, V9, P249, DOI 10.1007/s10888-011-9178-z
   Laborde S, 2018, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00458
   Laborde S, 2017, FRONT PSYCHOL, V8, DOI 10.3389/fpsyg.2017.00213
   Leppänen MH, 2020, PEDIATR DIABETES, V21, DOI 10.1111/pedi.12967
   Magge SN, 2017, PEDIATRICS, V140, DOI 10.1542/peds.2017-1603
   Mandy M, 2018, INT HEALTH, V10, P66, DOI 10.1093/inthealth/ihy006
   May LE, 2014, EARLY HUM DEV, V90, P33, DOI 10.1016/j.earlhumdev.2013.11.001
   McCraty R, 2014, FRONT PSYCHOL, V5, DOI 10.3389/fpsyg.2014.01090
   McEwen BS, 2017, METABOLISM, V69, pS21, DOI 10.1016/j.metabol.2017.01.018
   Messerli-Bürgy N, 2020, INT J PSYCHOPHYSIOL, V152, P102, DOI 10.1016/j.ijpsycho.2020.04.006
   Mestanikova A, 2019, J AFFECT DISORDERS, V249, P234, DOI 10.1016/j.jad.2019.01.043
   Mojtabavi H, 2020, COMPLEMENT THER CLIN, V39, DOI 10.1016/j.ctcp.2020.101162
   Moon SJE, 2024, J AM PSYCHIAT NURSES, V30, P240, DOI 10.1177/10783903221145142
   Mueller I, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.714664
   Muhtadie L, 2015, J PERS SOC PSYCHOL, V109, P106, DOI 10.1037/pspp0000016
   Mulkey SB, 2019, PEDIATR RES, V85, P120, DOI 10.1038/s41390-018-0155-0
   Naidoo T, 2012, CARDIOVASC J AFR, V23, P501, DOI 10.5830/CVJA-2012-058
   O'Connor MF, 2007, AM J PHYSIOL-REG I, V293, pR145, DOI 10.1152/ajpregu.00752.2006
   Olive LS, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0196137
   Pate RR, 2016, AM J PREV MED, V51, P12, DOI 10.1016/j.amepre.2015.12.003
   Perez EC, 2019, INT J DEV NEUROSCI, V78, P147, DOI 10.1016/j.ijdevneu.2019.06.006
   Petersen AMW, 2006, J PHYSIOL PHARMACOL, V57, P43
   Petrocchi N, 2019, PSYCHOL PSYCHOTHER-T, V92, P208, DOI 10.1111/papt.12224
   Phoemsapthawee J, 2019, J EXERC REHABIL, V15, P114
   Pivik RT, 2015, INT J PSYCHOPHYSIOL, V96, P104, DOI 10.1016/j.ijpsycho.2015.02.028
   Pivik RT, 2009, DEV NEUROPSYCHOL, V34, P139, DOI 10.1080/87565640802646726
   Porges SW, 2007, BIOL PSYCHOL, V74, P116, DOI 10.1016/j.biopsycho.2006.06.009
   Porges SW, 2022, FRONT INTEGR NEUROSC, V16, DOI 10.3389/fnint.2022.871227
   Porges SW, 2011, INFANT CHILD DEV, V20, P106, DOI 10.1002/icd.688
   Porges Stephen W, 2009, Cleve Clin J Med, V76 Suppl 2, pS86, DOI 10.3949/ccjm.76.s2.17
   Prinsloo GE, 2014, PHYSICIAN SPORTSMED, V42, P88, DOI 10.3810/psm.2014.05.2061
   Reimer P, 2017, THER CLIN RISK MANAG, V13, P1223, DOI 10.2147/TCRM.S143809
   Roth GA, 2020, J AM COLL CARDIOL, V76, P2982, DOI 10.1016/j.jacc.2020.11.010
   Schranz NK, 2016, J PHYS ACT HEALTH, V13, pS87, DOI 10.1123/jpah.2016-0345
   Shaffer F, 2017, FRONT PUBLIC HEALTH, V5, DOI 10.3389/fpubh.2017.00258
   Shahrestani S, 2015, BIOL PSYCHOL, V105, P43, DOI 10.1016/j.biopsycho.2014.12.012
   Silvetti MS, 2001, INT J CARDIOL, V81, P169, DOI 10.1016/S0167-5273(01)00537-X
   Singh N, 2018, ARRHYTH ELECTROPHYSI, V7, P247, DOI 10.15420/aer.2018.30.2
   Speer KE, 2022, APPL PHYSIOL NUTR ME, V47, P51, DOI 10.1139/apnm-2021-0207
   Speer KE, 2020, PHYSIOL BEHAV, V217, DOI 10.1016/j.physbeh.2020.112806
   Sun F, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-449
   Taralov Zdravko Z, 2015, Folia Med (Plovdiv), V57, P173, DOI 10.1515/folmed-2015-0036
   Thayer JF, 2006, ANN NY ACAD SCI, V1088, P361, DOI 10.1196/annals.1366.014
   Thayer JF, 2010, INT J CARDIOL, V141, P122, DOI 10.1016/j.ijcard.2009.09.543
   Thomas J, 2017, BMC CARDIOVASC DISOR, V17, DOI [10.1186/s12872-017-0578-2, 10.1186/s12889-017-4394-5]
   Todorova V, 2017, CURR NEUROPHARMACOL, V15, P166, DOI 10.2174/1570159X14666160414111821
   Tracey KJ, 2009, NAT REV IMMUNOL, V9, P418, DOI 10.1038/nri2566
   Tremblay MS, 2022, J PHYS ACT HEALTH, V19, P693, DOI 10.1123/jpah.2022-0257
   van Biljon A, 2018, CARDIOLOGY, V141, P1, DOI 10.1159/000492457
   van den Berg ME, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00424
   van Dijk AE, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030413
   Viitasalo A, 2016, PREV MED, V87, P81, DOI 10.1016/j.ypmed.2016.02.027
   Voss A, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0118308
   Weihrauch-Blüher S, 2019, METABOLISM, V92, P147, DOI 10.1016/j.metabol.2018.12.001
   Weiner O.M., 2016, J. Psychophysiol.
   Xhyheri B, 2012, PROG CARDIOVASC DIS, V55, P321, DOI 10.1016/j.pcad.2012.09.001
   Young HA, 2018, BEHAV PHARMACOL, V29, P140, DOI 10.1097/FBP.0000000000000383
NR 86
TC 3
Z9 3
U1 2
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
EI 1873-507X
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD JUL 1
PY 2024
VL 281
AR 114576
DI 10.1016/j.physbeh.2024.114576
EA MAY 2024
PG 6
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA TB1E1
UT WOS:001238697500001
PM 38692385
DA 2025-06-11
ER

PT J
AU Capellini, VK
   Celotto, AC
   Baldo, CF
   Olivon, VC
   Viaro, F
   Rodrigues, AJ
   Evora, PRB
AF Capellini, Verena K.
   Celotto, Andrea C.
   Baldo, Caroline F.
   Olivon, Vania C.
   Viaro, Fernanda
   Rodrigues, Alfredo J.
   Evora, Paulo R. B.
TI Diabetes and Vascular Disease: Basic Concepts of Nitric Oxide
   Physiology, Endothelial Dysfunction, Oxidative Stress and Therapeutic
   Possibilities
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Article
DE Endothelium; nitric oxide; diabetes; vascular dysfunction; oxidative
   stress; antioxidants; advanced glycation end-products
ID GLYCATION END-PRODUCTS; ALPHA-LIPOIC ACID; PROTEIN-KINASE-C;
   LOW-DENSITY-LIPOPROTEIN; INTIMA-MEDIA THICKNESS; VITAMIN-E
   SUPPLEMENTATION; SMOOTH-MUSCLE RELAXATION; 3RD NATIONAL-HEALTH; ERECTILE
   DYSFUNCTION; METABOLIC SYNDROME
AB The vascular manifestations associated with diabetes mellitus (DM) result from the dysfunction of several vascular physiology components mainly involving the endothelium, vascular smooth muscle and platelets. It is also known that hyperglycemia-induced oxidative stress plays a role in the development of this dysfunction. This review considers the basic physiology of the endothelium, especially related to the synthesis and function of nitric oxide. We also discuss the pathophysiology of vascular disease associated with DM. This includes the role of hyperglycemia in the induction of oxidative stress and the role of advanced glycation end-products. We also consider therapeutic strategies.
C1 [Capellini, Verena K.; Celotto, Andrea C.; Baldo, Caroline F.; Olivon, Vania C.; Viaro, Fernanda; Rodrigues, Alfredo J.; Evora, Paulo R. B.] Univ Sao Paulo, Dept Cirurgia & Anat, Fac Med Ribeirao Preto, BR-14048900 Ribeirao Preto, SP, Brazil.
C3 Universidade de Sao Paulo
RP Capellini, VK (corresponding author), Univ Sao Paulo, Dept Cirurgia & Anat, Fac Med Ribeirao Preto, 9 Andar HC,Av Bandeirantes 3900, BR-14048900 Ribeirao Preto, SP, Brazil.
EM verenacapellini@yahoo.com.br
RI Olivon, Vania Claudia/GNH-1889-2022; Rodrigues, Alfredo/C-3426-2013;
   Evora, Paulo/C-3351-2013; Celotto, Andrea/G-2370-2012
OI Celotto, Andrea/0000-0003-0037-7468; Olivon, Vania/0000-0001-6689-0972;
   Rodrigues, Alfredo J/0000-0002-0654-2893
FU CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior);
   FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo); FAEPA
   (Fundacao de Apoio ao Ensino, Pesquisa e Assistencia do Hospital das
   Clinicas da Faculdade de Medicina de Ribeirao Preto da Universidade de
   Sao Paulo), Brazil
FX The work in the authors' laboratory is supported by CAPES (Coordenacao
   de Aperfeicoamento de Pessoal de Nivel Superior), FAPESP (Fundacao de
   Amparo a Pesquisa do Estado de Sao Paulo) and FAEPA (Fundacao de Apoio
   ao Ensino, Pesquisa e Assistencia do Hospital das Clinicas da Faculdade
   de Medicina de Ribeirao Preto da Universidade de Sao Paulo), Brazil.
CR Abdel-Aal NM, 2008, SAUDI MED J, V29, P1423
   Aiello LP, 2002, SURV OPHTHALMOL, V47, pS263, DOI 10.1016/S0039-6257(02)00391-0
   Alnaeb ME, 2007, IN VIVO, V21, P1069
   Alpha-Tocopherol Beta Carotene Cancer Prevention Study Group, 1994, N Engl J Med, V330, P1029, DOI 10.1056/NEJM199404143301501
   Ametov AS, 2003, DIABETES CARE, V26, P770, DOI 10.2337/diacare.26.3.770
   Amos AF, 1997, DIABETIC MED, V14, pS7, DOI 10.1002/(SICI)1096-9136(199712)14:5+<S7::AID-DIA522>3.3.CO;2-I
   ANDERSEN AR, 1983, DIABETOLOGIA, V25, P496
   ANDERSSON KE, 1995, PHYSIOL REV, V75, P191, DOI 10.1152/physrev.1995.75.1.191
   Angulo J, 1996, HYPERTENSION, V28, P583, DOI 10.1161/01.HYP.28.4.583
   ARAI K, 1987, J BIOL CHEM, V262, P16969
   Arnal JF, 1999, CELL MOL LIFE SCI, V55, P1078, DOI 10.1007/s000180050358
   Aronson D, 2002, MED HYPOTHESES, V59, P297, DOI 10.1016/S0306-9877(02)00172-X
   Barile GR, 2005, INVEST OPHTH VIS SCI, V46, P2916, DOI 10.1167/iovs.04-1409
   Battaini F, 2007, PHARMACOL RES, V55, P461, DOI 10.1016/j.phrs.2007.05.005
   Beckman JA, 2003, AM J PHYSIOL-HEART C, V285, pH2392, DOI 10.1152/ajpheart.00403.2003
   Beckman JA, 2001, CIRCULATION, V103, P1618, DOI 10.1161/01.CIR.103.12.1618
   BEM AF, 2006, BRAS PATOL MED LAB, V42, P185
   Bierhaus A, 1997, DIABETES, V46, P1481, DOI 10.2337/diab.46.9.1481
   Bivalacqua TJ, 2001, BIOCHEM BIOPH RES CO, V283, P923, DOI 10.1006/bbrc.2001.4874
   Bivalacqua TJ, 2003, J ANDROL, V24, pS17
   Blaschke F, 2006, ARTERIOSCL THROM VAS, V26, P28, DOI 10.1161/01.ATV.0000191663.12164.77
   Boaz M, 2000, LANCET, V356, P1213, DOI 10.1016/S0140-6736(00)02783-5
   BOJESTIG M, 1994, NEW ENGL J MED, V330, P15, DOI 10.1056/NEJM199401063300103
   Bönisch D, 1998, MOL PHARMACOL, V54, P241, DOI 10.1124/mol.54.2.241
   Borcea V, 1999, FREE RADICAL BIO MED, V26, P1495, DOI 10.1016/S0891-5849(99)00011-8
   BORCHJOHNSEN K, 1985, DIABETOLOGIA, V28, P590, DOI 10.1007/BF00281993
   BORCHJOHNSEN K, 1989, DAN MED BULL, V36, P336
   Bots ML, 2007, EUR HEART J, V28, P398, DOI 10.1093/eurheartj/ehl482
   Boullier A, 2001, ANN NY ACAD SCI, V947, P214
   BOWIE A, 1993, ATHEROSCLEROSIS, V102, P63, DOI 10.1016/0021-9150(93)90084-8
   BROHALL G, 2008, NUTR METAB CARDIOVAS
   Brown BG, 2005, JAMA-J AM MED ASSOC, V293, P1387, DOI 10.1001/jama.293.11.1387
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   BROWNLEE M, 1988, NEW ENGL J MED, V318, P1315
   Bruckdorfer Richard, 2005, Molecular Aspects of Medicine, V26, P3, DOI 10.1016/j.mam.2004.09.002
   Bucci M, 2004, ARTERIOSCL THROM VAS, V24, P721, DOI 10.1161/01.ATV.0000122362.44628.09
   Bucci M, 2008, VASC PHARMACOL, V49, P84, DOI 10.1016/j.vph.2008.06.002
   Bucciarelli LG, 2008, DIABETES, V57, P1941, DOI 10.2337/db07-0326
   Burnett AL, 1996, MOL MED, V2, P288, DOI 10.1007/BF03401627
   Burnett AL, 2000, INT J IMPOT RES, V12, pS42, DOI 10.1038/sj.ijir.3900560
   Bursell SE, 1996, INVEST OPHTH VIS SCI, V37, P886
   Cai H, 2000, CIRC RES, V87, P840, DOI 10.1161/01.RES.87.10.840
   Caldwell RB, 2005, CURR DRUG TARGETS, V6, P511, DOI 10.2174/1389450054021981
   Calkin AC, 2008, DIABETOLOGIA, V51, P1731, DOI 10.1007/s00125-008-1060-6
   Campochiaro PA, 2004, EXPERT OPIN BIOL TH, V4, P1395, DOI 10.1517/14712598.4.9.1395
   Cartledge JJ, 2000, BJU INT, V85, P735, DOI 10.1046/j.1464-410x.2000.00599.x
   Cartledge JJ, 2001, BJU INT, V87, P402, DOI 10.1046/j.1464-410x.2001.00067.x
   Ceylan-Isik A, 2007, J PHARM PHARMACOL, V59, P1629, DOI 10.1211/jpp.59.12.0004
   Chang Shirley S, 2008, Pediatr Endocrinol Rev, V5 Suppl 4, P974
   Cheitlin Melvin D, 2003, Prev Cardiol, V6, P161, DOI 10.1111/j.1520-037X.2003.01488.x
   Chen S, 2000, KIDNEY INT, V58, pS40, DOI 10.1046/j.1523-1755.2000.07707.x
   Chibber R, 2007, CURR DIABETES REV, V3, P3, DOI 10.2174/157339907779802139
   Cohen MP, 2007, AM J PHYSIOL-RENAL, V292, pF789, DOI 10.1152/ajprenal.00201.2006
   Cohen MP, 2006, J LAB CLIN MED, V147, P211, DOI 10.1016/j.lab.2005.12.006
   Collins R, 2002, LANCET, V360, P23, DOI 10.1016/S0140-6736(02)09328-5
   CORNWELL TL, 1994, AM J PHYSIOL-CELL PH, V267, pC1405, DOI 10.1152/ajpcell.1994.267.5.C1405
   Cosentino F, 1998, J CARDIOVASC PHARM, V32, pS54
   Cosentino F, 1997, CIRCULATION, V96, P25
   Creager MA, 2003, CIRCULATION, V108, P1527, DOI 10.1161/01.CIR.0000091257.27563.32
   da Costa VAV, 2005, CLIN CHIM ACTA, V351, P101, DOI 10.1016/j.cccn.2004.08.007
   Daneman D, 2006, LANCET, V367, P847, DOI 10.1016/S0140-6736(06)68341-4
   Das Evcimen N, 2007, PHARMACOL RES, V55, P498, DOI 10.1016/j.phrs.2007.04.016
   Dávila-Esqueda ME, 2005, RENAL FAILURE, V27, P115, DOI 10.1081/JDI-200042728
   De Acular LGK, 2006, DIABETES CARE, V29, P1083, DOI 10.2337/dc05-2146
   de Dios ST, 2006, CURR DIABETES REV, V2, P227, DOI 10.2174/157339906776818622
   de Tejada IS, 2005, J SEX MED, V2, P26, DOI 10.1111/j.1743-6109.2005.20103.x
   Deguchi J, 2006, CIRCULATION, V114, P55, DOI 10.1161/CIRCULATIONAHA.106.619056
   Deng D, 1999, DIABETOLOGIA, V42, P1228, DOI 10.1007/s001250051296
   DIMITRIADIS E, 1995, DIABETOLOGIA, V38, P1300
   Dimitriadis E, 1996, DIABETOLOGIA, V39, P667
   Du XL, 2000, P NATL ACAD SCI USA, V97, P12222, DOI 10.1073/pnas.97.22.12222
   Du XL, 2001, J CLIN INVEST, V108, P1341, DOI 10.1172/JCI200111235
   Duarte J, 1999, EUR J PHARMACOL, V365, P225, DOI 10.1016/S0014-2999(98)00879-6
   Dunsmuir WD, 1996, DIABETIC MED, V13, P700, DOI 10.1002/(SICI)1096-9136(199608)13:8<700::AID-DIA174>3.0.CO;2-8
   FEKE GT, 1994, INVEST OPHTH VIS SCI, V35, P2968
   FIORETTO P, 1992, AM J KIDNEY DIS, V20, P549, DOI 10.1016/S0272-6386(12)70217-2
   FISCHER TH, 1987, BIOCHEM BIOPH RES CO, V149, P700, DOI 10.1016/0006-291X(87)90424-4
   Fitzgerald SM, 2005, CLIN EXP PHARMACOL P, V32, P482, DOI 10.1111/j.1440-1681.2005.04216.x
   FLECHA FLG, 2000, GLUCOSILACION ENZIMA, P1
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Frank RN, 2004, NEW ENGL J MED, V350, P48, DOI 10.1056/NEJMra021678
   Freitas MG, 2003, J HYPERTENS, V21, P1505, DOI 10.1097/00004872-200308000-00014
   Gæde P, 2001, DIABETIC MED, V18, P756, DOI 10.1046/j.0742-3071.2001.00574.x
   Geroldi D, 2006, CURR MED CHEM, V13, P1971, DOI 10.2174/092986706777585013
   GISINGER C, 1988, DIABETES, V37, P1260, DOI 10.2337/diabetes.37.9.1260
   Goldin A, 2006, CIRCULATION, V114, P597, DOI 10.1161/CIRCULATIONAHA.106.621854
   Gruden G, 2005, CURR DIABETES REV, V1, P27, DOI 10.2174/1573399052952622
   Guyton JR, 1998, AM J CARDIOL, V82, p85U, DOI 10.1016/S0002-9149(98)00956-4
   Haidara M, 2004, MED SCI MONITOR, V10, pBR41
   HAIDARA MA, 2008, J DIABETES COMPLICAT
   Harashima A, 2006, BIOCHEM J, V396, P109, DOI 10.1042/BJ20051573
   Harhaj NS, 2004, INT J BIOCHEM CELL B, V36, P1206, DOI 10.1016/j.biocel.2003.08.007
   HARRIS RD, 1991, KIDNEY INT, V40, P107, DOI 10.1038/ki.1991.187
   Hattori Y, 2002, HYPERTENSION, V39, P22, DOI 10.1161/hy1201.097300
   Hattori Y, 2001, BIOCHEM BIOPH RES CO, V281, P891, DOI 10.1006/bbrc.2001.4436
   Higai K, 2006, CLIN CHIM ACTA, V367, P137, DOI 10.1016/j.cca.2005.12.008
   Hink U, 2001, CIRC RES, V88, pE14
   Hodis HN, 1998, ANN INTERN MED, V128, P262, DOI 10.7326/0003-4819-128-4-199802150-00002
   Hofmann MA, 1998, DIABETES CARE, V21, P1310, DOI 10.2337/diacare.21.8.1310
   Inoguchi T, 2000, DIABETES, V49, P1939, DOI 10.2337/diabetes.49.11.1939
   Ishii H, 1996, SCIENCE, V272, P728, DOI 10.1126/science.272.5262.728
   Jariyapongskul A, 2007, MICROVASC RES, V74, P32, DOI 10.1016/j.mvr.2007.03.002
   Järvisalo MJ, 2002, DIABETES, V51, P493, DOI 10.2337/diabetes.51.2.493
   Jawa A, 2004, MED CLIN N AM, V88, P1001, DOI 10.1016/j.mcna.2004.04.012
   Johansen JS, 2005, CARDIOVASC DIABETOL, V4, DOI 10.1186/1475-2840-4-5
   Johnsen-Soriano S, 2008, FREE RADICAL RES, V42, P613, DOI 10.1080/10715760802206791
   Kablak-Ziembicka A, 2004, HEART, V90, P1286, DOI 10.1136/hrt.2003.025080
   KAISER N, 1993, DIABETES, V42, P80, DOI 10.2337/diabetes.42.1.80
   Kalogeropoulou K, 2002, ANGIOLOGY, V53, P279, DOI 10.1177/000331970205300305
   Kamboj SS, 2008, METAB BRAIN DIS, V23, P427, DOI 10.1007/s11011-008-9104-7
   Kelly DJ, 2001, J AM SOC NEPHROL, V12, P2098, DOI 10.1681/ASN.V12102098
   King GL, 2008, J PERIODONTOL, V79, P1527, DOI 10.1902/jop.2008.080246
   Kobrin SM, 1998, DM-DIS MON, V44, P214, DOI 10.1016/S0011-5029(98)90022-0
   KOPPENOL WH, 1992, CHEM RES TOXICOL, V5, P834, DOI 10.1021/tx00030a017
   Kowluru RA, 2003, FREE RADICAL RES, V37, P1169, DOI 10.1080/10715760310001604189
   Kowluru RA, 2002, FREE RADICAL RES, V36, P993, DOI 10.1080/1071576021000006572
   KOWLURU RA, 1989, BIOCHEMISTRY-US, V28, P2220, DOI 10.1021/bi00431a038
   Kowluru RA, 2007, EXP DIABETES RES, DOI 10.1155/2007/43603
   Koyama H, 2005, ARTERIOSCL THROM VAS, V25, P2587, DOI 10.1161/01.ATV.0000190660.32863.cd
   Kreisberg RA, 1998, AM J CARDIOL, V82, p67U, DOI 10.1016/S0002-9149(98)00848-0
   Lai MH, 2008, J CLIN BIOCHEM NUTR, V43, P191, DOI 10.3164/jcbn.2008064
   Laursen JB, 2001, CIRCULATION, V103, P1282
   Lehninger A. L., 2005, Lehninger-Principles of Biochemistry
   Li JP, 2007, CIRC J, V71, P1067, DOI 10.1253/circj.71.1067
   LINCOLN TM, 1993, FASEB J, V7, P328, DOI 10.1096/fasebj.7.2.7680013
   Lonn E, 2002, DIABETES CARE, V25, P1919, DOI 10.2337/diacare.25.11.1919
   Lonn E, 2005, JAMA-J AM MED ASSOC, V293, P1338, DOI 10.1001/jama.293.11.1338
   Lonn EM, 2001, CIRCULATION, V103, P919
   LUZ J, 2008, DIABETES METAB
   MacArthur PH, 2007, J CHROMATOGR B, V851, P93, DOI 10.1016/j.jchromb.2006.12.012
   Madsen-Bouterse SA, 2008, REV ENDOCR METAB DIS, V9, P315, DOI 10.1007/s11154-008-9090-4
   Majithiya JB, 2006, LIFE SCI, V78, P2615, DOI 10.1016/j.lfs.2005.10.020
   Mathew V, 2004, CIRCULATION, V109, P476, DOI 10.1161/01.CIR.0000109693.64957.20
   MAUER SM, 1984, J CLIN INVEST, V74, P1143, DOI 10.1172/JCI111523
   Maxwell AJ, 2002, NITRIC OXIDE-BIOL CH, V6, P101, DOI 10.1006/niox.2001.0394
   MCVEIGH GE, 1992, DIABETOLOGIA, V35, P771
   Michel FS, 2008, BRIT J PHARMACOL, V155, P217, DOI 10.1038/bjp.2008.256
   Milstien S, 1999, BIOCHEM BIOPH RES CO, V263, P681, DOI 10.1006/bbrc.1999.1422
   Miranda PJ, 2005, AM HEART J, V149, P20, DOI 10.1016/j.ahj.2004.07.012
   Miranda PJ, 2005, AM HEART J, V149, P33, DOI 10.1016/j.ahj.2004.07.013
   Mizuno M, 2002, HYPERTENS RES, V25, P271, DOI 10.1291/hypres.25.271
   Mohan V, 2000, DIABETOLOGIA, V43, P494, DOI 10.1007/s001250051334
   Montorsi F, 2003, EUR UROL, V44, P360, DOI 10.1016/S0302-2838(03)00305-1
   Montorsi P, 2003, EUR UROL, V44, P352, DOI 10.1016/S0302-2838(03)00307-5
   Moreland RB, 2001, J PHARMACOL EXP THER, V296, P225
   MORLEY JE, 1988, AM J MED, V84, P445, DOI 10.1016/0002-9343(88)90264-1
   NAGAMATSU M, 1995, DIABETES CARE, V18, P1160, DOI 10.2337/diacare.18.8.1160
   Nathan DM, 2005, NEW ENGL J MED, V353, P2643, DOI 10.1056/nejmoa052187
   NELSON RG, 1993, DIABETES CARE, V16, P335, DOI 10.2337/diacare.16.1.335
   Nishikawa T, 2000, NATURE, V404, P787, DOI 10.1038/35008121
   Oldfield MD, 2001, J CLIN INVEST, V108, P1853
   Omenn GS, 1996, NEW ENGL J MED, V334, P1150, DOI 10.1056/NEJM199605023341802
   Osicka TM, 2000, DIABETES, V49, P87, DOI 10.2337/diabetes.49.1.87
   Parham Mahmoud, 2008, Rev Diabet Stud, V5, P102, DOI 10.1900/RDS.2008.5.102
   Peerapatdit Thavatchai, 2006, J Med Assoc Thai, V89 Suppl 5, pS147
   Peppa-Patrikiou M, 1998, DIABETES CARE, V21, P1004, DOI 10.2337/diacare.21.6.1004
   Pfeifer A, 1998, EMBO J, V17, P3045, DOI 10.1093/emboj/17.11.3045
   Phillips AO, 2002, HISTOL HISTOPATHOL, V17, P247, DOI 10.14670/HH-17.247
   Phillips C, 2005, ATHEROSCLEROSIS, V181, P109, DOI 10.1016/j.atherosclerosis.2004.12.033
   Pieper GM, 1997, J PHARMACOL EXP THER, V283, P684
   Pigazzi A, 1999, J BIOL CHEM, V274, P14368, DOI 10.1074/jbc.274.20.14368
   Podlasek CA, 2001, J UROLOGY, V166, P746, DOI 10.1016/S0022-5347(05)66054-5
   Prescott J, 1999, BBA-MOL CELL BIOL L, V1439, P110, DOI 10.1016/S1388-1981(99)00082-7
   PUJIA A, 1994, DIABETES CARE, V17, P1330, DOI 10.2337/diacare.17.11.1330
   Rang H.P., 2004, Farmacologia, V5th ed.
   Rask-Madsen C, 2005, ARTERIOSCL THROM VAS, V25, P487, DOI 10.1161/01.ATV.0000155325.41507.e0
   Rask-Madsen C, 2007, NAT CLIN PRACT ENDOC, V3, P46, DOI 10.1038/ncpendmet0366
   RASMUSSEN H, 1984, BIOCHEM BIOPH RES CO, V122, P776, DOI 10.1016/S0006-291X(84)80101-1
   REAVEN GM, 1995, PHYSIOL REV, V75, P473, DOI 10.1152/physrev.1995.75.3.473
   Reljanovic M, 1999, FREE RADICAL RES, V31, P171, DOI 10.1080/10715769900300721
   Reusch JEB, 2007, DIABETES OBES METAB, V9, P455, DOI 10.1111/j.1463-1326.2006.00620.x
   Ricciardolo FLM, 2004, PHYSIOL REV, V84, P731, DOI 10.1152/physrev.00034.2003
   Rolo AP, 2006, TOXICOL APPL PHARM, V212, P167, DOI 10.1016/j.taap.2006.01.003
   Romeo G, 2002, DIABETES, V51, P2241, DOI 10.2337/diabetes.51.7.2241
   Romeo JH, 2000, J UROLOGY, V163, P788, DOI 10.1016/S0022-5347(05)67805-6
   ROSENFELD ME, 2007, VULNERABLE ATHEROSCL, P384
   ROSSING P, 1995, DIABETES, V44, P739, DOI 10.2337/diabetes.44.7.739
   Ruhnau KJ, 1999, DIABETIC MED, V16, P1040, DOI 10.1046/j.1464-5491.1999.00190.x
   Sakaguchi T, 2003, J CLIN INVEST, V111, P959, DOI 10.1172/JCI200317115
   Sato T, 2006, CURR MOL MED, V6, P351, DOI 10.2174/156652406776894536
   Savoia C, 2007, HYPERTENSION, V49, P341, DOI 10.1161/01.HYP.0000253968.95136.b8
   Schalkwijk Casper G, 2002, Semin Vasc Med, V2, P191, DOI 10.1055/s-2002-32042
   Schalkwijk CG, 2005, CLIN SCI, V109, P143, DOI 10.1042/CS20050025
   SCHMIDT AM, 1994, ARTERIOSCLER THROMB, V14, P1521, DOI 10.1161/01.ATV.14.10.1521
   Schmidt AM, 1996, DIABETES, V45, pS77, DOI 10.2337/diab.45.3.S77
   Seftel AD, 1997, UROLOGY, V50, P1016, DOI 10.1016/S0090-4295(97)00512-8
   Sharma R, 2006, FRONT BIOSCI-LANDMRK, V11, P968, DOI 10.2741/1853
   Singh R, 2001, DIABETOLOGIA, V44, P129, DOI 10.1007/s001250051591
   Siraj ES, 2006, METABOLISM, V55, P706, DOI 10.1016/j.metabol.2005.08.002
   Skyrme-Jones RAP, 2000, J AM COLL CARDIOL, V36, P94, DOI 10.1016/S0735-1097(00)00720-8
   Soldatos G, 2008, DIABETES RES CLIN PR, V82, pS75, DOI 10.1016/j.diabres.2008.09.042
   Solomon H, 2003, AM J CARDIOL, V91, P230, DOI 10.1016/S0002-9149(02)03113-2
   Sowers JR, 2004, AM J HYPERTENS, V17, p2S, DOI 10.1016/j.amjhyper.2004.08.007
   Srivastava S K, 1989, Prog Clin Biol Res, V304, P171
   Stern DM, 2002, AGEING RES REV, V1, P1, DOI 10.1016/S0047-6374(01)00366-9
   Stitt AW, 2004, DIABETOLOGIA, V47, P1735, DOI 10.1007/s00125-004-1523-3
   Stitt AW, 2003, EXP MOL PATHOL, V75, P95, DOI 10.1016/S0014-4800(03)00035-2
   Stitt AW, 1997, AM J PATHOL, V150, P523
   Sullivan ME, 1999, CARDIOVASC RES, V43, P658, DOI 10.1016/S0008-6363(99)00135-2
   Sun JS, 2007, NAT MED, V13, P719, DOI 10.1038/nm1601
   Takagi C, 1996, INVEST OPHTH VIS SCI, V37, P2504
   Tan KCB, 2007, DIABETOLOGIA, V50, P1819, DOI 10.1007/s00125-007-0759-0
   Tan KCB, 2002, DIABETES CARE, V25, P1055, DOI 10.2337/diacare.25.6.1055
   Tanji N, 2000, J AM SOC NEPHROL, V11, P1656, DOI 10.1681/ASN.V1191656
   Tolentino MJ, 1996, OPHTHALMOLOGY, V103, P1820, DOI 10.1016/S0161-6420(96)30420-X
   Triggle Chris R., 2003, Journal of Smooth Muscle Research, V39, P249, DOI 10.1540/jsmr.39.249
   Turner RC, 1998, BMJ-BRIT MED J, V316, P823, DOI 10.1136/bmj.316.7134.823
   Twigg SM, 2002, ENDOCRINOLOGY, V143, P4907, DOI 10.1210/en.2002-220619
   Twigg SM, 2001, ENDOCRINOLOGY, V142, P1760, DOI 10.1210/endo.142.5.8141
   Usta MF, 2003, J UROLOGY, V170, P1437, DOI 10.1097/01.ju.0000077557.45582.f3
   Valagussa F, 1999, LANCET, V354, P447, DOI 10.1016/S0140-6736(99)07072-5
   Valeri C, 2004, DIABETES-METAB RES, V20, pS1, DOI 10.1002/dmrr.512
   Vallance P, 2001, HEART, V85, P342, DOI 10.1136/heart.85.3.342
   Vanhoutte PM, 2003, CIRC J, V67, P572
   Viaro F, 2000, Arq Bras Cardiol, V74, P380
   WABREK AJ, 1980, ARCH SEX BEHAV, V9, P69, DOI 10.1007/BF01541402
   Wajcberg E, 2007, J CLIN ENDOCR METAB, V92, P1256, DOI 10.1210/jc.2006-1910
   Wajchenberg Bernardo Léo, 2002, Arq Bras Endocrinol Metab, V46, P514, DOI 10.1590/S0004-27302002000500004
   Walford G, 2003, J THROMB HAEMOST, V1, P2112, DOI 10.1046/j.1538-7836.2003.00345.x
   Wautier MP, 2001, AM J PHYSIOL-ENDOC M, V280, pE685, DOI 10.1152/ajpendo.2001.280.5.E685
   Wendt T, 2003, J AM SOC NEPHROL, V14, P1383, DOI 10.1097/01.ASN.0000065100.17349.CA
   West NEJ, 2004, CIRCULATION, V109, P867, DOI 10.1161/01.CIR.0000116750.63158.94
   Wever RMF, 1998, CIRCULATION, V97, P108, DOI 10.1161/01.CIR.97.1.108
   WOFFORD JL, 1991, ARTERIOSCLER THROMB, V11, P1786, DOI 10.1161/01.ATV.11.6.1786
   Wong TY, 2008, AM J OPHTHALMOL, V146, P656, DOI 10.1016/j.ajo.2008.07.048
   XIA P, 1994, DIABETES, V43, P1122, DOI 10.2337/diabetes.43.9.1122
   Xia P, 1996, J CLIN INVEST, V98, P2018, DOI 10.1172/JCI119006
   Xu B, 2003, FASEB J, V17, P1289, DOI 10.1096/fj.02-0490fje
   Yim MB, 2001, ANN NY ACAD SCI, V928, P48, DOI 10.1111/j.1749-6632.2001.tb05634.x
   Yki-Jarvinen H, 2004, NEW ENGL J MED, V351, P1106, DOI 10.1056/NEJMra041001
   Yonekura H, 2005, J PHARMACOL SCI, V97, P305, DOI 10.1254/jphs.CPJ04005X
   Yonekura H, 2003, BIOCHEM J, V370, P1097, DOI 10.1042/BJ20021371
   Yusuf S, 2000, NEW ENGL J MED, V342, P154, DOI 10.1056/NEJM200001203420302
   Zhang J, 1996, J BIOL CHEM, V271, P6265, DOI 10.1074/jbc.271.11.6265
   Ziegler D, 1999, DIABETES CARE, V22, P1296, DOI 10.2337/diacare.22.8.1296
   Ziegler D, 1997, DIABETES CARE, V20, P369, DOI 10.2337/diacare.20.3.369
   ZIEGLER D, 1995, DIABETOLOGIA, V38, P1425, DOI 10.1007/BF00400603
   Ziegler D, 2006, DIABETES CARE, V29, P2365, DOI 10.2337/dc06-1216
   Ziyadeh FN, 2008, DIABETES RES CLIN PR, V82, pS38, DOI 10.1016/j.diabres.2008.09.016
   Zobali Fulya, 2002, Int J Exp Diabetes Res, V3, P119, DOI 10.1080/15604280214484
   Zou MH, 2004, ENDOTHELIUM-J ENDOTH, V11, P89, DOI 10.1080/10623320490482619
NR 242
TC 46
Z9 49
U1 1
U2 9
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
EI 1875-6212
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PD JUL
PY 2010
VL 8
IS 4
BP 526
EP 544
PG 19
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA 628LZ
UT WOS:000280122900009
PM 19485895
DA 2025-06-11
ER

PT J
AU Karaca, M
   Coban, E
   Felek, R
   Unal, M
AF Karaca, Mustafa
   Coban, Erkan
   Felek, Rasih
   Unal, Mustafa
TI The Association of Oxidative Stress with Hypertensive Retinopathy
SO CLINICAL AND EXPERIMENTAL HYPERTENSION
LA English
DT Article
DE gamma-glutamyl transferase; oxidative stress; hypertension; hypertensive
   retinopathy
ID GAMMA-GLUTAMYL-TRANSFERASE; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   RISK; DETERMINANTS; PLASMA; LEVEL
AB This study was designed to answer the following questions: (i) Do levels of serum gamma-glutamyl transferase (GGT), a marker of oxidative stress, change in hypertensive retinopathy (HR)? (ii) Is there any relation between degree of HR and GGT levels? This study included 80 hypertensive patients with HR. Group 1 comprised 40 patients with grade I HR, and group 2 comprised 40 patients with grade II HR. We selected 40 healthy subjects for the control group. Level of GGT in group 2 was significantly higher than in group 1 (P = 0.005) and control group (P = 0.001); it was also higher in group 1 than in control group (P = 0.025). Our study suggests that oxidative stress, mechanisms known to be involved in vascular lesions, may promote the development of HR.
C1 [Karaca, Mustafa; Coban, Erkan] Akdeniz Univ, Dept Internal Med, Fac Med, TR-07070 Antalya, Turkey.
   [Felek, Rasih] Akdeniz Univ, Cent Lab, Fac Med, TR-07070 Antalya, Turkey.
   [Unal, Mustafa] Akdeniz Univ, Dept Ophthalmol, Fac Med, TR-07070 Antalya, Turkey.
C3 Akdeniz University; Akdeniz University; Akdeniz University
RP Coban, E (corresponding author), Akdeniz Univ, Dept Internal Med, Fac Med, TR-07070 Antalya, Turkey.
EM ecoban@akdeniz.edu.tr
RI Coban, Erkan/AAA-7821-2021; Felek, Rasih/I-8896-2017; ÜNAL,
   MUSTAFA/C-7426-2016
CR André P, 2006, DIABETOLOGIA, V49, P2599, DOI 10.1007/s00125-006-0418-x
   Arkkila PET, 2001, DIABETES RES CLIN PR, V52, P113, DOI 10.1016/S0168-8227(00)00241-2
   CHOBANIAN AV, 2003, JAMA-J AM MED ASSOC, V289, P2560, DOI DOI 10.1161/01.HYP.0000107251.49515.C2
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Coban E, 2010, MED SCI MONITOR, V16, pCR92
   DellaCroce JT, 2008, CURR OPIN OPHTHALMOL, V19, P493, DOI 10.1097/ICU.0b013e3283129779
   Emdin M, 2005, CIRCULATION, V112, P2078, DOI 10.1161/CIRCULATIONAHA.105.571919
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Giner V, 2004, J INTERN MED, V255, P588, DOI 10.1046/j.1365-2796.2003.01280.x
   Kawamoto R, 2009, J ATHEROSCLER THROMB, V16, P355, DOI 10.5551/jat.No414
   KEITH NM, 1974, AM J MED SCI, V268, P336, DOI 10.1097/00000441-197412000-00004
   Lee DH, 2004, J HUM HYPERTENS, V18, P803, DOI 10.1038/sj.jhh.1001742
   Lee DH, 2003, CLIN CHEM, V49, P1358, DOI 10.1373/49.8.1358
   Lee DS, 2007, ARTERIOSCL THROM VAS, V27, P127, DOI 10.1161/01.ATV.0000251993.20372.40
   LOWENTHAL MN, 1993, SOUTHERN MED J, V86, P190, DOI 10.1097/00007611-199302000-00010
   Manning RD, 2005, AM J NEPHROL, V25, P311, DOI 10.1159/000086411
   Minuz P, 2004, HYPERTENSION, V43, P64, DOI 10.1161/01.HYP.0000105109.44620.1B
   Nakanishi N, 2004, DIABETES CARE, V27, P1427, DOI 10.2337/diacare.27.6.1427
   Poikolainen K, 1997, AM J EPIDEMIOL, V146, P1019, DOI 10.1093/oxfordjournals.aje.a009230
   Porta M, 2005, J HYPERTENS, V23, P683, DOI 10.1097/01.hjh.0000163131.77267.11
   Portaluppi F, 2004, CURR PHARM DESIGN, V10, P1695, DOI 10.2174/1381612043384619
   Purushothaman S, 2011, MOL CELL BIOCHEM, V351, P59, DOI 10.1007/s11010-011-0711-y
   Shankar A, 2007, CIRC J, V71, P1567, DOI 10.1253/circj.71.1567
   Whitfield JB, 2001, CRIT REV CL LAB SCI, V38, P263, DOI 10.1080/20014091084227
   Wong T, 2007, LANCET, V369, P425, DOI 10.1016/S0140-6736(07)60198-6
   Wong TY, 2005, BRIT MED BULL, V73-74, P57, DOI 10.1093/bmb/ldh050
   Yamada Y, 1995, Hypertens Res, V18, P295, DOI 10.1291/hypres.18.295
   Yilmaz MI, 2005, EUR J ENDOCRINOL, V152, P233, DOI 10.1530/eje.1.01851
   Zeng CY, 2009, CLIN EXP HYPERTENS, V31, P156, DOI 10.1080/10641960802621283
NR 29
TC 9
Z9 10
U1 0
U2 7
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1064-1963
EI 1525-6006
J9 CLIN EXP HYPERTENS
JI Clin. Exp. Hypertens.
PY 2013
VL 35
IS 1
BP 16
EP 19
DI 10.3109/10641963.2012.685535
PG 4
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA 061SY
UT WOS:000312869700004
PM 22571627
DA 2025-06-11
ER

PT J
AU Palomer, X
   Pizarro-Delgado, J
   Vázquez-Carrera, M
AF Palomer, Xavier
   Pizarro-Delgado, Javier
   Vazquez-Carrera, Manuel
TI Emerging Actors in Diabetic Cardiomyopathy: Heartbreaker Biomarkers or
   Therapeutic Targets?
SO TRENDS IN PHARMACOLOGICAL SCIENCES
LA English
DT Review
ID ENDOPLASMIC-RETICULUM STRESS; HEART-FAILURE; INSULIN-RESISTANCE;
   DIASTOLIC DYSFUNCTION; PHARMACOLOGICAL INHIBITION; TRANSCRIPTIONAL
   REGULATION; METABOLIC SYNDROME; OXIDATIVE STRESS; PPAR-BETA/DELTA;
   DOWN-REGULATION
AB The diabetic heart is characterized by metabolic disturbances that are often accompanied by local inflammation, oxidative stress, myocardial fibrosis, and cardiomyocyte apoptosis. Overall changes result in contractile dysfunction, concentric left ventricular (LV) hypertrophy, and dilated cardiomyopathy, that together affect cardiac output and eventually lead to heart failure, the foremost cause of death in diabetic patients. There are currently several validated biomarkers for the diagnosis and risk assessment of cardiac diseases, but none is capable of discriminating patients with diabetic cardiomyopathy (DCM). In this review we point to several novel candidate biomarkers from new activated molecular pathways (including microRNAs) with the potential to detect or prevent DCM in its early stages, or even to treat it once established. The prospective use of selected biomarkers that integrate inflammation, oxidative stress, fibrosis, and metabolic dysregulation is widely discussed.
C1 [Palomer, Xavier; Pizarro-Delgado, Javier; Vazquez-Carrera, Manuel] IBUB, Dept Pharmacol Toxicol & Therapeut Chem, Barcelona, Spain.
   [Palomer, Xavier; Pizarro-Delgado, Javier; Vazquez-Carrera, Manuel] Hosp St Joan de Deu, Res Inst, Barcelona, Spain.
   [Palomer, Xavier; Pizarro-Delgado, Javier; Vazquez-Carrera, Manuel] Univ Barcelona, Fac Pharm & Food Sci, Ctr Invest Biomed Red CIBER Diabet & Enfermedades, Barcelona, Spain.
C3 University of Barcelona; University of Barcelona; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEREHD; University of Barcelona
RP Vázquez-Carrera, M (corresponding author), IBUB, Dept Pharmacol Toxicol & Therapeut Chem, Barcelona, Spain.; Vázquez-Carrera, M (corresponding author), Hosp St Joan de Deu, Res Inst, Barcelona, Spain.; Vázquez-Carrera, M (corresponding author), Univ Barcelona, Fac Pharm & Food Sci, Ctr Invest Biomed Red CIBER Diabet & Enfermedades, Barcelona, Spain.
EM mvazquezcarrera@ub.edu
RI PIZARRO-DELGADO, JAVIER/E-7268-2012; Vazquez-Carrera, Manuel/H-2612-2015
OI PIZARRO-DELGADO, JAVIER/0000-0002-3735-844X; Vazquez-Carrera,
   Manuel/0000-0001-7138-8207; Palomer, Xavier/0000-0001-7647-9984
FU Spanish Ministry of Economy and Competitiveness [SAF2015-64146-R];
   Fundacio La Marato de TV3; CIBER de Diabetes y Enfermedades Metabolicas
   Asociadas (CIBERDEM)
FX We apologize to contributors to the field whose work could not be cited
   here owing to space restrictions. We thank the University of Barcelona
   Language Advisory Service for their assistance. Funding for the authors
   is from the Spanish Ministry of Economy and Competitiveness
   (SAF2015-64146-R), the Fundacio La Marato de TV3, and CIBER de Diabetes
   y Enfermedades Metabolicas Asociadas (CIBERDEM). CIBERDEM is an
   initiative of the Instituto de Salud Carlos III (ISCIII), Spanish
   Ministry of Economy and Competitiveness.
CR Akbal E, 2009, ENDOCRINE, V36, P433, DOI 10.1007/s12020-009-9243-6
   Alonso N, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-016-0470-x
   [Anonymous], 2016, Oxid Med Cell Longevity
   Asghar O, 2009, CLIN SCI, V116, P741, DOI 10.1042/CS20080500
   Berezin AE, 2017, DIAB MET SYND CLIN R, V11, pS201, DOI 10.1016/j.dsx.2016.12.032
   Berezin AE, 2016, DIAB MET SYND CLIN R, V10, pS154, DOI 10.1016/j.dsx.2015.09.016
   Berthiaume JM, 2019, ANTIOXID REDOX SIGN, V30, P375, DOI 10.1089/ars.2017.7415
   Besler C, 2017, CIRC-HEART FAIL, V10, DOI 10.1161/CIRCHEARTFAILURE.116.003804
   Blumensatt M, 2013, CARDIOVASC RES, V100, P201, DOI 10.1093/cvr/cvt173
   Burkart EM, 2007, J CLIN INVEST, V117, P3930, DOI 10.1172/JCI32578
   Burkhard T, 2009, EUR J RADIOL, V71, P69, DOI 10.1016/j.ejrad.2008.03.022
   Caputto BL, 2014, BBA-MOL CELL BIOL L, V1841, P1241, DOI 10.1016/j.bbalip.2014.05.007
   Care A, 2007, NAT MED, V13, P613, DOI 10.1038/nm1582
   Chen WJY, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-150
   Chugh S, 2013, PROTEOMICS, V13, P2324, DOI 10.1002/pmic.201200455
   Coué M, 2016, BIOCHIMIE, V124, P84, DOI 10.1016/j.biochi.2015.05.017
   Deng X, 2017, ONCOTARGET, V8, P63038, DOI 10.18632/oncotarget.18593
   Díaz-Delfín J, 2012, ENDOCRINOLOGY, V153, P4238, DOI 10.1210/en.2012-1193
   Dirkx E, 2011, PROSTAG LEUKOTR ESS, V85, P219, DOI 10.1016/j.plefa.2011.04.018
   Dlamini Z, 2015, EXP MOL PATHOL, V98, P574, DOI 10.1016/j.yexmp.2015.03.022
   Du XL, 2003, J CLIN INVEST, V112, P1049, DOI 10.1172/JCI200318127
   Duan YQ, 2013, EXP CELL RES, V319, P173, DOI 10.1016/j.yexcr.2012.11.015
   Duisters RF, 2009, CIRC RES, V104, P170, DOI 10.1161/CIRCRESAHA.108.182535
   el Azzouzi H, 2013, CELL METAB, V18, P341, DOI 10.1016/j.cmet.2013.08.009
   Faul C, 2011, J CLIN INVEST, V121, P4393, DOI 10.1172/JCI46122
   Fontes-Carvalho R, 2015, CARDIOVASC DIABETOL, V14, DOI 10.1186/s12933-014-0168-x
   Fousteris E, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-101
   Fu SH, 2016, CLIN INTERV AGING, V11, P1531, DOI 10.2147/CIA.S109583
   Gamella-Pozuelo L, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000001218
   Gandhi PU, 2016, JACC-HEART FAIL, V4, P860, DOI 10.1016/j.jchf.2016.08.002
   Guo R, 2017, BBA-MOL BASIS DIS, V1863, P2070, DOI 10.1016/j.bbadis.2017.03.013
   Hamid T, 2011, CARDIOVASC RES, V89, P129, DOI 10.1093/cvr/cvq274
   Harmancey R, 2012, FASEB J, V26, P3118, DOI 10.1096/fj.12-208991
   Hattori Y, 2000, J PHYSIOL-LONDON, V527, P85, DOI 10.1111/j.1469-7793.2000.00085.x
   Hoffmann U, 2015, BMC CARDIOVASC DISOR, V15, DOI 10.1186/s12872-015-0026-0
   Hogas S, 2017, ARCH MED SCI, V13, P897, DOI 10.5114/aoms.2016.58664
   Horie T, 2009, BIOCHEM BIOPH RES CO, V389, P315, DOI 10.1016/j.bbrc.2009.08.136
   Hsieh MCF, 2008, J BIOL CHEM, V283, P27410, DOI 10.1074/jbc.M802418200
   Hung HC, 2013, INT J CARDIOL, V169, pE33, DOI 10.1016/j.ijcard.2013.08.112
   Jeyabal P, 2016, BIOCHEM BIOPH RES CO, V471, P423, DOI 10.1016/j.bbrc.2016.02.065
   Ji LL, 2017, DIABETES, V66, P1586, DOI 10.2337/db16-1237
   Jonker JW, 2012, NATURE, V485, P391, DOI 10.1038/nature10998
   Jweied EE, 2005, AM J PHYSIOL-HEART C, V289, pH2478, DOI 10.1152/ajpheart.00638.2005
   Kastrup J, 2012, IMMUNOBIOLOGY, V217, P483, DOI 10.1016/j.imbio.2011.04.007
   Korkmaz-Icöz S, 2016, AM J PHYSIOL-HEART C, V311, pH958, DOI 10.1152/ajpheart.00956.2015
   Kuwabara Y, 2015, CIRC RES, V116, P279, DOI 10.1161/CIRCRESAHA.116.304707
   Lee WS, 2017, KOREAN J INTERN MED, V32, P404, DOI 10.3904/kjim.2016.208
   León LE, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/6143129
   Li PP, 2016, CELL, V167, P973, DOI 10.1016/j.cell.2016.10.025
   Li X, 2014, CELL DEATH DIS, V5, DOI 10.1038/cddis.2014.430
   Li ZH, 2007, J CLIN BIOCHEM NUTR, V41, P58, DOI 10.3164/jcbn.2007008
   Ling H, 2004, BIOCHEM J, V380, P651, DOI 10.1042/BJ20040099
   Liu FH, 2015, CIRCULATION, V131, P795, DOI 10.1161/CIRCULATIONAHA.114.012285
   Llauradó G, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0140222
   Lorenzo O, 2011, MEDIAT INFLAMM, V2011, DOI 10.1155/2011/652097
   Lorenzo-Almorós A, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-017-0506-x
   Lu H, 2010, CARDIOVASC RES, V86, P410, DOI 10.1093/cvr/cvq010
   Martin-Du-Pan Remy C, 2017, Rev Med Suisse, V13, P660
   Martínez-Martínez E, 2018, J HYPERTENS, V36, P368, DOI 10.1097/HJH.0000000000001545
   Matsusaka H, 2006, HYPERTENSION, V47, P711, DOI 10.1161/01.HYP.0000208840.30778.00
   McGuire DK, 2008, CIRCULATION, V117, P440, DOI 10.1161/CIRCULATIONAHA.107.704080
   Mohamad HE, 2011, DIABETOL METAB SYNDR, V3, DOI 10.1186/1758-5996-3-4
   Moro C, 2016, EXPERT OPIN THER TAR, V20, P1445, DOI 10.1080/14728222.2016.1254198
   Palomer X, 2015, DIS MODEL MECH, V8, P1081, DOI 10.1242/dmm.020768
   Palomer X, 2014, INT J CARDIOL, V174, P110, DOI 10.1016/j.ijcard.2014.03.176
   Palomer X, 2013, INT J CARDIOL, V168, P3160, DOI 10.1016/j.ijcard.2013.07.150
   Palomer X, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019724
   Pereira L, 2006, DIABETES, V55, P608, DOI 10.2337/diabetes.55.03.06.db05-1284
   Planavila A, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3019
   Planavila A, 2015, CARDIOVASC RES, V106, P19, DOI 10.1093/cvr/cvu263
   Pugliese G, 2014, CLIN CHEM LAB MED, V52, P1413, DOI 10.1515/cclm-2014-0187
   Quilliot D, 2005, INT J OBESITY, V29, P1321, DOI 10.1038/sj.ijo.0803022
   Rathcke CN, 2006, INFLAMM RES, V55, P53, DOI 10.1007/s00011-005-0010-8
   Raut SK, 2016, MOL CELL BIOCHEM, V417, P191, DOI 10.1007/s11010-016-2729-7
   Rayner JJ, 2018, INT J OBESITY, V42, P441, DOI 10.1038/ijo.2017.239
   Redfield MM, 2003, JAMA-J AM MED ASSOC, V289, P194, DOI 10.1001/jama.289.2.194
   Rehli M, 2003, J BIOL CHEM, V278, P44058, DOI 10.1074/jbc.M306792200
   Rehman SU, 2008, J AM COLL CARDIOL, V52, P1458, DOI 10.1016/j.jacc.2008.07.042
   Rijzewijk LJ, 2008, J AM COLL CARDIOL, V52, P1793, DOI 10.1016/j.jacc.2008.07.062
   Russell NE, 2009, DIABETES CARE, V32, P2050, DOI 10.2337/dc09-0552
   Sala D, 2014, J CLIN INVEST, V124, P1914, DOI 10.1172/JCI72327
   Seldin MM, 2017, AM J PHYSIOL-HEART C, V312, pH728, DOI 10.1152/ajpheart.00068.2016
   Sharma V, 2011, WORLD J CARDIOL, V3, P281, DOI 10.4330/wjc.v3.i9.281
   Shaver A, 2016, INT J MED SCI, V13, P161, DOI 10.7150/ijms.14141
   Shen YH, 2013, CELL BIOCHEM BIOPHYS, V66, P139, DOI 10.1007/s12013-012-9462-y
   Takahashi N, 2005, J MOL CELL CARDIOL, V38, P185, DOI 10.1016/j.yjmcc.2004.10.016
   Tan Y, 2011, DIABETES, V60, P625, DOI 10.2337/db10-1164
   Thrainsdottir IS, 2005, DIABETES CARE, V28, P612, DOI 10.2337/diacare.28.3.612
   Tian R, 2003, CURR HYPERTENS REP, V5, P454, DOI 10.1007/s11906-003-0052-7
   Ucar A, 2012, NAT COMMUN, V3, DOI 10.1038/ncomms2090
   Unsicker K, 2013, CYTOKINE GROWTH F R, V24, P373, DOI 10.1016/j.cytogfr.2013.05.003
   Copier CU, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-13875-2
   van de Weijer T, 2011, CARDIOVASC RES, V92, P10, DOI 10.1093/cvr/cvr212
   Van Linthout S, 2007, DIABETOLOGIA, V50, P1977, DOI 10.1007/s00125-007-0719-8
   Vela D, 2017, BMC ENDOCR DISORD, V17, DOI 10.1186/s12902-017-0204-4
   Vetter R, 2002, FASEB J, V16, P1657, DOI 10.1096/fj.01-1019fje
   Volz HC, 2010, BASIC RES CARDIOL, V105, P805, DOI 10.1007/s00395-010-0114-3
   Wang M, 2009, ACTA PHARMACOL SIN, V30, P1081, DOI 10.1038/aps.2009.95
   Wang WK, 2017, EXP THER MED, V14, P2497, DOI 10.3892/etm.2017.4824
   Wang WK, 2014, J CELL MOL MED, V18, P2311, DOI 10.1111/jcmm.12399
   Wang WK, 2014, INT J CARDIOL, V172, P202, DOI 10.1016/j.ijcard.2014.01.011
   Wang ZV, 2015, CIRCULATION, V131, P771, DOI 10.1161/CIRCULATIONAHA.115.015357
   Wu F, 2017, CLIN SCI, V131, P1877, DOI 10.1042/CS20170271
   Yildirim SS, 2013, CELL BIOCHEM BIOPHYS, V67, P1397, DOI 10.1007/s12013-013-9672-y
   Younce CW, 2010, CARDIOVASC RES, V87, P665, DOI 10.1093/cvr/cvq102
   Yu LR, 2018, EXP BIOL MED, V243, P248, DOI 10.1177/1535370217746383
   Yu LL, 2013, CIRC-HEART FAIL, V6, P107, DOI 10.1161/CIRCHEARTFAILURE.112.971168
   Zhang Y, 2017, MOL PHARMACOL, V92, P211, DOI 10.1124/mol.117.108241
   Zhao JQ, 2016, CARDIOLOGY, V134, P340, DOI 10.1159/000443703
NR 109
TC 76
Z9 79
U1 0
U2 22
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0165-6147
EI 1873-3735
J9 TRENDS PHARMACOL SCI
JI Trends Pharmacol. Sci.
PD MAY
PY 2018
VL 39
IS 5
BP 452
EP 467
DI 10.1016/j.tips.2018.02.010
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GD5QY
UT WOS:000430562900003
PM 29605388
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Morgan, VA
   Waterreus, A
   Carr, V
   Castle, D
   Cohen, M
   Harvey, C
   Galletly, C
   Mackinnon, A
   McGorry, P
   McGrath, JJ
   Neil, AL
   Saw, S
   Badcock, JC
   Foley, DL
   Waghorn, G
   Coker, S
   Jablensky, A
AF Morgan, Vera A.
   Waterreus, Anna
   Carr, Vaughan
   Castle, David
   Cohen, Martin
   Harvey, Carol
   Galletly, Cherrie
   Mackinnon, Andrew
   McGorry, Patrick
   McGrath, John J.
   Neil, Amanda L.
   Saw, Suzy
   Badcock, Johanna C.
   Foley, Debra L.
   Waghorn, Geoff
   Coker, Sarah
   Jablensky, Assen
TI Responding to challenges for people with psychotic illness: Updated
   evidence from the Survey of High Impact Psychosis
SO AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
LA English
DT Review
DE Employment; social isolation; physical health; victimisation;
   schizophrenia
ID AUSTRALIAN NATIONAL-SURVEY; CARDIOMETABOLIC RISK-FACTORS; SERIOUS
   MENTAL-ILLNESS; VIOLENT VICTIMIZATION; DISORDERS DATA; SCHIZOPHRENIA;
   EMPLOYMENT; ADULTS; PREVALENCE; HEALTH
AB Objective: The objective is to summarise recent findings from the 2010 Australian Survey of High Impact Psychosis (SHIP) and examine their implications for future policy and planning to improve mental health, physical health and other circumstances of people with a psychotic disorder.
   Methods: Survey of High Impact Psychosis collected nationally representative data on 1825 people with psychotic illness. Over 60 papers have been published covering key challenges reported by participants: financial problems, loneliness and social isolation, unemployment, poor physical health, uncontrolled symptoms of mental illness, and lack of stable, suitable housing. Findings are summarised under the rubric of participant-ranked top challenges.
   Results: The main income source for the majority (85%) of participants was a government benefit. Only one-third was employed, and the most appropriate employment services for this group were under-utilised. High rates of loneliness and social isolation impacted mental and physical health. The rate of cardiometabolic disease was well above the general population rate, and associated risk factors were present from a very young age. Childhood abuse (30.6%), adult violent victimisation (16.4%) and alcohol and substance abuse/dependence (lifetime rates of 50.5% and 54.5%, respectively) complicated the clinical profile. Treatment with medication was suboptimal, with physical health conditions undertreated, a high rate of psychotropic polypharmacy and underutilisation of clozapine in chronic persistent psychotic illness. Only 38.6% received evidence-based psychosocial therapies. In the previous year, 27.4% had changed housing and 12.8% had been homeless, on average for 155days.
   Conclusion: Money, social engagement and employment are the most important challenges for people with psychotic illness, as well as good physical and mental health. An integrated approach to recovery is needed to optimise service delivery and augment evidence-based clinical practice with measures to improve physical health and social circumstances. Meeting these challenges has the potential to reduce costs to government and society, as well as promote recovery.
C1 [Morgan, Vera A.; Waterreus, Anna] Univ Western Australia, Sch Psychiat & Clin Neurosci, Neuropsychiat Epidemiol Res Unit, Crawley, WA, Australia.
   [Morgan, Vera A.; Badcock, Johanna C.; Jablensky, Assen] Univ Western Australia, Sch Psychiat & Clin Neurosci, Ctr Clin Res Neuropsychiat, Crawley, WA, Australia.
   [Carr, Vaughan] Univ New South Wales, Sch Psychiat, Res Unit Schizophrenia Epidemiol, Sydney, NSW, Australia.
   [Carr, Vaughan] Schizophrenia Res Inst, Sydney, NSW, Australia.
   [Carr, Vaughan] Neurosci Res Australia, Sydney, NSW, Australia.
   [Carr, Vaughan] Monash Univ, Sch Clin Sci, Dept Psychiat, Melbourne, Vic, Australia.
   [Castle, David] St Vincents Hosp, Melbourne, Vic, Australia.
   [Castle, David; Harvey, Carol] Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia.
   [Cohen, Martin] Hunter New England Mental Hlth, Newcastle, NSW, Australia.
   [Cohen, Martin] Univ Newcastle, Newcastle, NSW, Australia.
   [Galletly, Cherrie] Univ Adelaide, Sch Med, Discipline Psychiat, Adelaide, SA, Australia.
   [Galletly, Cherrie] Ramsay Hlth Care, Mental Hlth Serv, Adelaide, SA, Australia.
   [Galletly, Cherrie] Northern Adelaide Local Hlth Network, Adelaide, SA, Australia.
   [Mackinnon, Andrew] Black Dog Inst, Sydney, NSW, Australia.
   [Mackinnon, Andrew] Univ New South Wales, Sydney, NSW, Australia.
   [Mackinnon, Andrew] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Mental Hlth, Melbourne, Vic, Australia.
   [McGorry, Patrick] Orygen Youth Hlth Res Ctr, Melbourne, Vic, Australia.
   [McGrath, John J.] Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia.
   [McGrath, John J.; Waghorn, Geoff] Queensland Ctr Mental Hlth Res, Brisbane, Qld, Australia.
   [Neil, Amanda L.] Univ Tasmania, Inst Med Res, Hobart, Tas, Australia.
   [Saw, Suzy] Hlth Data Anal Pty Ltd, Canberra, ACT, Australia.
   [Badcock, Johanna C.; Jablensky, Assen] Cooperat Res Ctr Mental Hlth, Carlton, Vic, Australia.
   [Foley, Debra L.] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Fac Med Dent & Hlth Sci, Melbourne, Vic, Australia.
   [Coker, Sarah] SANE Australia, Melbourne, Vic, Australia.
C3 University of Western Australia; University of Western Australia;
   University of New South Wales Sydney; Schizophrenia Research Institute;
   Neuroscience Research Australia; Monash University; St Vincent's Health;
   St Vincent's Hospital Melbourne; NSW Health; St Vincents Hospital
   Sydney; University of Melbourne; University of Newcastle; University of
   Adelaide; Ramsay Health Care Limited; Black Dog Institute; University of
   New South Wales Sydney; University of Melbourne; Orygen, The National
   Centre of Excellence in Youth Mental Health; University of Queensland;
   Queensland Centre for Mental Health Research; University of Sydney;
   Westmead Institute for Medical Research; University of Tasmania;
   Cooperative Research Centre for Mental Health; University of Melbourne
RP Morgan, VA (corresponding author), Univ Western Australia, Sch Psychiat & Clin Neurosci, Neuropsychiat Epidemiol Res Unit, M571,35 Stirling Highway, Crawley, WA 6009, Australia.
EM vera.morgan@uwa.edu.au
RI McGorry, Patrick/O-4115-2019; Sponheim, Scott/J-3857-2017; Badcock,
   Johanna/C-3682-2013; Morgan, Vera/U-4851-2019; Mackinnon,
   Andrew/A-4901-2008; Harvey, Carol/KHB-1944-2024; Neil,
   Amanda/L-9052-2013; McGrath, John/G-5493-2010
OI Castle, David/0000-0002-3075-1580; McGorry, Patrick/0000-0002-3789-6168;
   Neil, Amanda/0000-0002-1344-6672; McGrath, John/0000-0002-4792-6068;
   Waterreus, Anna/0000-0002-1648-7701
CR [Anonymous], 2009, Report on the 2007 National Survey of Mental Health and Wellbeing
   [Anonymous], 2011, PEOPLE LIVING PSYCHO
   Badcock JC, 2015, SCHIZOPHR RES, V169, P268, DOI 10.1016/j.schres.2015.10.027
   Baptista T, 2012, AUST NZ J PSYCHIAT, V46, P901, DOI 10.1177/0004867412457088
   Berk M, 2012, AUST NZ J PSYCHIAT, V46, P801, DOI 10.1177/0004867412458001
   Bosanac Peter, 2016, Clin Schizophr Relat Psychoses, V10, P93, DOI 10.3371/1935-1232-10.2.93
   Campbell L, 2012, AUST NZ J PSYCHIAT, V46, P890, DOI 10.1177/0004867412455108
   Carr VJ, 2012, AUST NZ J PSYCHIAT, V46, P708, DOI 10.1177/0004867412446488
   Cascardi M, 1996, PSYCHIATR SERV, V47, P531
   Cooper J, 2012, AUST NZ J PSYCHIAT, V46, P851, DOI 10.1177/0004867412449876
   Dean K, 2007, ACTA PSYCHIAT SCAND, V116, P345, DOI 10.1111/j.1600-0447.2007.01078.x
   Drake RE, 2016, PSYCHIAT SERV, V67, P1138, DOI 10.1176/appi.ps.201500336
   Drake RE, 2013, AM J PSYCHIAT, V170, P1433, DOI 10.1176/appi.ajp.2013.13020214
   Foley D, 2016, LANCET PSYCHIAT, V3, P104, DOI 10.1016/S2215-0366(16)00004-3
   Foley DL, 2016, SCHIZOPHRENIA BULL, V42, P1280, DOI 10.1093/schbul/sbw027
   Foley DL, 2016, AUST NZ J PSYCHIAT, V50, P488, DOI 10.1177/0004867415595715
   Foley DL, 2015, LANCET PSYCHIAT, V2, P1092, DOI 10.1016/S2215-0366(15)00276-X
   Foley DL, 2015, AUST NZ J PSYCHIAT, V49, P714, DOI 10.1177/0004867414565476
   Foley DL, 2014, WORLD PSYCHIATRY, V13, P176, DOI 10.1002/wps.20130
   Foley DL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0082606
   Galletly C, 2016, AUST NZ J PSYCHIAT, V50, P410, DOI 10.1177/0004867416641195
   Galletly C, 2012, AUST NZ J PSYCHIAT, V46, P803, DOI 10.1177/0004867412458488
   Galletly CA, 2012, AUST NZ J PSYCHIAT, V46, P753, DOI 10.1177/0004867412453089
   Green MF, 2015, NAT REV NEUROSCI, V16, P620, DOI 10.1038/nrn4005
   Hahn L, 2014, AUST NZ J PSYCHIAT, V48, P70, DOI 10.1177/0004867413491158
   Hahn LA, 2014, AUST NZ J PSYCHIAT, V48, P1025, DOI 10.1177/0004867414553950
   Harvey C, 2016, AUST NZ J PSYCHIAT, V50, P534, DOI 10.1177/0004867415610437
   Harvey C, 2012, AUST NZ J PSYCHIAT, V46, P840, DOI 10.1177/0004867412449301
   Hawkley LC, 2010, ANN BEHAV MED, V40, P218, DOI 10.1007/s12160-010-9210-8
   Haydock M, 2015, COMPR PSYCHIAT, V58, P122, DOI 10.1016/j.comppsych.2015.01.003
   Hopper K., 2007, Recovery from schizophrenia: An international perspective: A report from the WHO Collaborative Project, the international study of schizophrenia
   Jablensky A, 2000, AUST NZ J PSYCHIAT, V34, P221, DOI 10.1080/j.1440-1614.2000.00728.x
   Jablensky A, 2008, SCHIZOPHRENIA BULL, V34, P253, DOI 10.1093/schbul/sbm151
   KIRKPATRICK B, 1989, PSYCHIAT RES, V30, P119, DOI 10.1016/0165-1781(89)90153-4
   Kredentser MS, 2014, J CLIN PSYCHIAT, V75, P154, DOI 10.4088/JCP.13m08711
   Lacey M, 2015, PSYCHIAT RES, V225, P723, DOI 10.1016/j.psychres.2014.09.010
   Laursen TM, 2011, SCHIZOPHR RES, V131, P101, DOI 10.1016/j.schres.2011.06.008
   Lawrence D, 2001, DUTY CARE PREVENTABL
   Lawrence D, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f2539
   Liu D, 2016, FRONT PSYCHIATRY, V7, DOI 10.3389/fpsyt.2016.00139
   Mancuso SG, 2015, J AFFECT DISORDERS, V172, P30, DOI 10.1016/j.jad.2014.09.035
   Marmot M, 2015, LANCET, V386, P2442, DOI 10.1016/S0140-6736(15)00150-6
   Meadows G, 2012, MENTAL HLTH AUSTR, P237
   Monroe-DeVita M, 2012, PSYCHIAT SERV, V63, P743, DOI 10.1176/appi.ps.201100015
   Moore E, 2012, AUST NZ J PSYCHIAT, V46, P864, DOI 10.1177/0004867412443900
   Morgan VA, 2014, PSYCHOL MED, V44, P2163, DOI 10.1017/S0033291713002973
   MORGAN V. A., 2012, ANZ J PSYCHIAT, V46, P735, DOI DOI 10.1177/0004867412449877
   Morgan VA, 2012, NATL PSYCHOSIS SURVE, P30
   Morgan VA, 2013, STRUNGMANN FORUM REP, P273
   Morgan VA, 2012, SCHIZOPHR RES, V136, pS73, DOI 10.1016/S0920-9964(12)70267-0
   Morgan VA, 2016, SOC PSYCH PSYCH EPID, V51, P269, DOI 10.1007/s00127-015-1155-6
   Morgan VA, 2013, AUST NZ J PSYCHIAT, V47, P486, DOI 10.1177/0004867413482494
   Morosini PL, 2000, ACTA PSYCHIAT SCAND, V101, P323, DOI 10.1111/j.1600-0447.2000.tb10933.x
   National Disability Insurance Agency (NDIA), 2016, Q REP COAG DIS REF C
   Neil A, 2016, AUST NZ J PSYCHIAT, V50, P495, DOI 10.1177/0004867415623861
   Neil AL, 2014, AUST NZ J PSYCHIAT, V48, P237, DOI 10.1177/0004867413508453
   Neil AL, 2014, AUST NZ J PSYCHIAT, V48, P169, DOI 10.1177/0004867413500352
   Nenke MA, 2015, SCHIZOPHR RES, V161, P465, DOI 10.1016/j.schres.2014.12.012
   Newman JM, 2010, J NERV MENT DIS, V198, P708, DOI 10.1097/NMD.0b013e3181f49bf1
   Nielsen RE, 2013, SCHIZOPHR RES, V146, P22, DOI DOI 10.1016/J.SCHRES.2013.02.025
   Poon AWC, 2017, EPIDEMIOL PSYCH SCI, V26, P265, DOI 10.1017/S2045796015001195
   Poon WC, 2015, INT J SOC PSYCHIATR, V61, P743, DOI 10.1177/0020764015577843
   Power BD, 2015, SCHIZOPHR RES, V168, P245, DOI 10.1016/j.schres.2015.06.026
   Power BD, 2014, SCHIZOPHR RES, V152, P300, DOI 10.1016/j.schres.2013.11.003
   Priebe S, 1998, SCHIZOPHRENIA BULL, V24, P469, DOI 10.1093/oxfordjournals.schbul.a033341
   Raudino A, 2014, AUST NZ J PSYCHIAT, V48, P341, DOI 10.1177/0004867413511996
   Read J, 2005, ACTA PSYCHIAT SCAND, V112, P330, DOI 10.1111/j.1600-0447.2005.00634.x
   Reeve R, 2013, ECON REC, V89, P300, DOI 10.1111/1475-4932.12044
   Saha S, 2015, EPIDEMIOL PSYCH SCI, V24, P534, DOI 10.1017/S2045796014000535
   Saha S, 2007, ARCH GEN PSYCHIAT, V64, P1123, DOI 10.1001/archpsyc.64.10.1123
   Saha S, 2014, AUST NZ J PSYCHIAT, V48, P352, DOI 10.1177/0004867413513341
   Sankaranarayanan A, 2016, AUSTRALAS PSYCHIATRY, V24, P437, DOI 10.1177/1039856216646232
   Sankaranarayanan A, 2014, PSYCHIAT RES, V215, P634, DOI 10.1016/j.psychres.2013.12.032
   Shah S, 2014, SCHIZOPHR RES, V159, P20, DOI 10.1016/j.schres.2014.07.011
   Sheridan AJ, 2015, INT J SOC PSYCHIATR, V61, P241, DOI 10.1177/0020764014540150
   Silver E, 2005, AM J PUBLIC HEALTH, V95, P2015, DOI 10.2105/AJPH.2003.021436
   Siskind DJ, 2017, EPIDEMIOL PSYCH SCI, V26, P325, DOI 10.1017/S2045796016000305
   Stain HJ, 2012, AUST NZ J PSYCHIAT, V46, P879, DOI 10.1177/0004867412449060
   Stefanis NC, 2014, SCHIZOPHR RES, V156, P211, DOI 10.1016/j.schres.2014.04.003
   Stefanis NC, 2013, SCHIZOPHRENIA BULL, V39, P251, DOI 10.1093/schbul/sbs188
   Stolk Y, 2015, INT J SOC PSYCHIATR, V61, P319, DOI 10.1177/0020764014543710
   Suetani S, 2016, ACTA PSYCHIAT SCAND, V134, P129, DOI 10.1111/acps.12594
   Sweeney S, 2015, FRONT PUBLIC HEALTH, V3, DOI 10.3389/fpubh.2015.00259
   Sweeney S, 2015, FRONT PSYCHOL, V6, DOI 10.3389/fpsyg.2015.01768
   Sylvestre J, 2007, AM J COMMUN PSYCHOL, V40, P125, DOI 10.1007/s10464-007-9129-9
   Toh WL, 2016, PSYCHIAT RES, V243, P238, DOI 10.1016/j.psychres.2016.06.035
   Toh WL, 2016, AUSTR NZ J PSYCHIAT, V50, P9
   Waghorn G, 2016, BRIT J OCCUP THER, V79, P290, DOI 10.1177/0308022616631547
   Waghorn G, 2016, PSYCHIATR REHABIL J, V39, P112, DOI 10.1037/prj0000185
   Waghorn G, 2014, PSYCHIAT SERV, V65, P476, DOI 10.1176/appi.ps.201300096
   Waghorn G, 2012, AUST NZ J PSYCHIAT, V46, P774, DOI 10.1177/0004867412452015
   Waterreus A, 2016, PSYCHOL MED, V46, P1651, DOI 10.1017/S0033291715002883
   Waterreus A, 2012, AUST NZ J PSYCHIAT, V46, P762, DOI 10.1177/0004867412450471
   Westcott C, 2015, AM J PSYCHIATR REHAB, V18, P187, DOI 10.1080/15487768.2014.954162
   World Health Organization, 1999, SCHED CLIN ASS NEUR
NR 95
TC 86
Z9 92
U1 0
U2 21
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0004-8674
EI 1440-1614
J9 AUST NZ J PSYCHIAT
JI Aust. N. Z. J. Psych.
PD FEB
PY 2017
VL 51
IS 2
BP 124
EP 140
DI 10.1177/0004867416679738
PG 17
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EL5PB
UT WOS:000394672000005
PM 27913580
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Aliyazicioglu, R
   Deger, O
   Kural, BV
   Hocaoglu, Ç
   Çolak, M
   Yücesan, FB
AF Aliyazicioglu, Rezzan
   Deger, Orhan
   Kural, Birgul Vanizor
   Hocaoglu, Cicek
   Colak, Meltem
   Yucesan, Fulya Balaban
TI The Relationship Between the Peroxisome Proliferator-Activated Receptor
   Gamma 2 Gene Polymorphism, Lipids and Adipokines in Patients with Major
   Depression
SO TURKIYE KLINIKLERI TIP BILIMLERI DERGISI
LA English
DT Article
DE Adipokines; lipids; major depressive disorder; single nucleotide
   polymorphisms; PPAR gamma
ID INSULIN-RESISTANCE; PRO12ALA POLYMORPHISM; METABOLIC SYNDROME;
   DIABETES-MELLITUS; BODY-MASS; EXPRESSION; OBESITY; ADIPONECTIN;
   PPAR-GAMMA-2; LEPTIN
AB Objective: Peroxisome proliferator-activated receptor gamma (PPAR gamma), lipids, lipoproteins, and adipokines have recently been shown to be associated with psychiatric diseases. Our major aim is to investigate the contribution of the PPAR gamma gene polymorphism, adipokines, lipids, and lipoproteins to the development of major depression. Material and Methods: The frequency of Pro12Ala in exon 2 and C478T in exon 6 of the PPAR gamma gene, lipids and adipokines in major depression (n = 78) and control subjects (n = 64) were analyzed. Genotypes of PPAR gamma gene polymorphisms were examined. Serum leptin, adiponectin, and resistin were studied by enzyme-linked immunosorbent assay (ELISA). Serum apo A1, apo B, and Lp(a) levels were determined by immunonephelometry. Serum total cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol levels were analyzed by enzymatic methods. Results: The genotypes of exon 2 and exon 6 distribution did not differ between the control subjects and patients with major depression. Frequencies of genotypes of Pro12Ala, and Ala12Ala in exon 2 in overweight and obese patients with major depression were higher than those of overweight and obese controls. C478T polymorphism was highest in overweight and obese patients with major depression. Pro12Ala and Ala12Ala genotypes in exon 2 of PPAR gamma gene in patients were found to be associated with triglyceride and HDL-cholesterol. There were significant differences regarding glucose, total cholesterol, LDL-cholesterol, apo B, Lp(a), adiponectin and resistin levels between patient and control subjects. Conclusion: PPAR gamma exon gene polymorphisms, alterations in lipid profile and adipokines may be associated with the development of major depression.
C1 [Deger, Orhan; Kural, Birgul Vanizor; Yucesan, Fulya Balaban] Karadeniz Tech Univ, Fac Med, Dept Biochem, Trabzon, Turkey.
   [Aliyazicioglu, Rezzan] Karadeniz Tech Univ, Fac Pharm, Dept Biochem, Trabzon, Turkey.
   [Hocaoglu, Cicek] Rize Univ, Fac Med, Dept Psychiat, Rize, Turkey.
   [Colak, Meltem] Gumushane Univ, High Sch Hlth, Dept Nursing, Gumushane, Turkey.
C3 Karadeniz Technical University; Karadeniz Technical University; Recep
   Tayyip Erdogan University; Ministry of National Education - Turkey;
   Gumushane University
RP Deger, O (corresponding author), Karadeniz Tech Univ, Fac Med, Dept Biochem, Trabzon, Turkey.
EM orhandeger@hotmail.com
RI Hocaoglu, Cicek/B-2543-2014; YÜCESAN, Fulya/AAR-5398-2020; Deger,
   Orhan/ABF-9220-2020; ALİYAZICIOĞLU, REZZAN/AAK-2965-2021
OI VANIZOR KURAL, Birgul/0000-0003-0730-9660
FU Karadeniz Technical University [2006. 101. 0014. 1]
FX The authors thank Karadeniz Technical University Resarch Fund (Project
   no: 2006. 101. 0014. 1) for supplying financial support.
CR Abdelrahman M, 2005, CARDIOVASC RES, V65, P772, DOI 10.1016/j.cardiores.2004.12.008
   American Psychiatric Association, 1994, Diagnostic and statistical manual of mental disorders, V4, P943
   Aydemir Ö, 2009, TURK PSIKIYATR DERG, V20, P205
   Barroso I, 1999, NATURE, V402, P880, DOI 10.1038/47254
   Cardona F, 2006, CLIN CHEM, V52, P1920, DOI 10.1373/clinchem.2006.069690
   Deeb SS, 1998, NAT GENET, V20, P284, DOI 10.1038/3099
   Fajas L, 1998, FEBS LETT, V438, P55, DOI 10.1016/S0014-5793(98)01273-3
   Fajas L, 1997, J BIOL CHEM, V272, P18779, DOI 10.1074/jbc.272.30.18779
   Friedman JM, 1998, NATURE, V395, P763, DOI 10.1038/27376
   Haseeb A, 2009, J BIOSCIENCES, V34, P405, DOI 10.1007/s12038-009-0047-x
   Hivert MF, 2008, J CLIN ENDOCR METAB, V93, P3165, DOI 10.1210/jc.2008-0425
   Ji-Rong Y, 2009, ARCH MED RES, V40, P411, DOI 10.1016/j.arcmed.2009.05.005
   Kallen CB, 1996, P NATL ACAD SCI USA, V93, P5793, DOI 10.1073/pnas.93.12.5793
   Maeda N, 2001, DIABETES, V50, P2094, DOI 10.2337/diabetes.50.9.2094
   Meirhaeghe A, 2000, INT J OBESITY, V24, P195, DOI 10.1038/sj.ijo.0801112
   Memisoglu A, 2003, HUM MOL GENET, V12, P2923, DOI 10.1093/hmg/ddg318
   Ristow M, 1998, NEW ENGL J MED, V339, P953, DOI 10.1056/NEJM199810013391403
   Sato K, 2004, POULTRY SCI, V83, P1342, DOI 10.1093/ps/83.8.1342
   Silha JV, 2003, EUR J ENDOCRINOL, V149, P331, DOI 10.1530/eje.0.1490331
   Spiegelman BM, 1996, CELL, V87, P377, DOI 10.1016/S0092-8674(00)81359-8
   Steppan CM, 2001, NATURE, V409, P307, DOI 10.1038/35053000
   Stumvoll M, 2002, DIABETES, V51, P2341, DOI 10.2337/diabetes.51.8.2341
   Swarbrick MM, 2001, EUR J ENDOCRINOL, V144, P277, DOI 10.1530/eje.0.1440277
   Tai ES, 2004, J LIPID RES, V45, P674, DOI 10.1194/jlr.M300363-JLR200
   TONTONOZ P, 1994, CELL, V79, P1147, DOI 10.1016/0092-8674(94)90006-X
   Valve R, 1999, J CLIN ENDOCR METAB, V84, P3708, DOI 10.1210/jc.84.10.3708
   VidalPuig AJ, 1997, J CLIN INVEST, V99, P2416, DOI 10.1172/JCI119424
   Way JM, 2001, J BIOL CHEM, V276, P25651, DOI 10.1074/jbc.C100189200
   Weber-Hamann B, 2007, J PSYCHIATR RES, V41, P344, DOI 10.1016/j.jpsychires.2006.01.002
   Yamashita S, 1996, DIABETES CARE, V19, P287, DOI 10.2337/diacare.19.3.287
   Yang Baichun, 2004, BMC Pharmacology, V4, P23, DOI 10.1186/1471-2210-4-23
   Yen CJ, 1997, BIOCHEM BIOPH RES CO, V241, P270, DOI 10.1006/bbrc.1997.7798
   Zhang B, 1996, J BIOL CHEM, V271, P9455, DOI 10.1074/jbc.271.16.9455
NR 33
TC 9
Z9 9
U1 0
U2 9
PU ORTADOGU AD PRES & PUBL CO
PI ANKARA
PA TURKOCAGI CAD NO 30, BALGAT, ANKARA, 06520, TURKEY
SN 1300-0292
J9 TURK KLIN TIP BILIM
JI Turk. Klin. Tip Bilim. Derg.
PD OCT
PY 2011
VL 31
IS 5
BP 1065
EP 1072
DI 10.5336/medsci.2010-20010
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 853OD
UT WOS:000297434700003
OA hybrid
DA 2025-06-11
ER

PT J
AU Wang, YL
   Zhou, X
   Li, DL
   Ye, JM
AF Wang, Ya-lin
   Zhou, Xiu
   Li, Dong-li
   Ye, Ji-ming
TI Role of the mTOR-autophagy-ER stress pathway in high fructose-induced
   metabolic-associated fatty liver disease
SO ACTA PHARMACOLOGICA SINICA
LA English
DT Review
DE mTOR; autophagy; ER stress; MAFLD; metabolic syndrome; high-fructose
   diet
ID ENDOPLASMIC-RETICULUM STRESS; INSULIN SIGNALING TRANSDUCTION; HEPATIC
   STEATOSIS; RAT-LIVER; ZEBRAFISH; COMPLEX; TARGET; DIET; INFLAMMATION;
   DIAGNOSIS
AB Metabolic-associated fatty liver disease (MAFLD) is the most common metabolic disease with a global prevalence of 25%. While MAFLD is serious and incurable at the later stage, it can be controlled or reversed at the early stage of hepatosteatosis originating from unhealthy diets. Recent laboratory evidence implicates a critical role of the mammalian target of rapamycin (mTOR)-autophagy signaling pathway in the pathogenesis of MAFLD induced by a high-fructose diet mimicking the overconsumption of sugar in humans. This review discusses the possible molecular mechanisms of mTOR-autophagy-endoplasmic reticulum (ER) stress in MAFLD. Based on careful analysis of recent studies, we suggest possible new therapeutic concepts or targets that can be explored for the discovery of new anti-MAFLD drugs.
C1 [Wang, Ya-lin; Zhou, Xiu; Li, Dong-li; Ye, Ji-ming] Wuyi Univ, Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China.
   [Zhou, Xiu; Ye, Ji-ming] RMIT Univ, Sch Hlth & Biomed Sci, Melbourne, Vic, Australia.
C3 Wuyi University; Royal Melbourne Institute of Technology (RMIT)
RP Ye, JM (corresponding author), Wuyi Univ, Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China.
EM jiming.ye@rmit.edu.au
FU National Natural Science Foundation of China [81870608]; Jiangmen
   Innovation Research Team Project Fund [2018630100180019806]
FX The authors would like to acknowledge Prof Li-hong Hu and Prof Hua-liang
   Jiang (Shanghai Institute of Materia Medica, China) for collaborative
   research on matrine. We would also like to thank Dr. Hao Wang (RMIT
   University, Australia), who significantly contributed to our initial
   study on the relationship among mTOR, autophagy and ER stress in high
   fructose-induced hepatosteatosis. This review was supported in part by
   the National Natural Science Foundation of China (81870608) and Jiangmen
   Innovation Research Team Project Fund (2018630100180019806).
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Anckar J, 2011, ANNU REV BIOCHEM, V80, P1089, DOI 10.1146/annurev-biochem-060809-095203
   Arab JP, 2018, ANNU REV PATHOL-MECH, V13, P321, DOI 10.1146/annurev-pathol-020117-043617
   Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI 10.1002/hep.29367
   Chou SD, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039679
   Cotter TG, 2020, GASTROENTEROLOGY, V158, P1851, DOI 10.1053/j.gastro.2020.01.052
   Dai WC, 2015, NUTR METAB, V12, DOI 10.1186/s12986-015-0036-z
   Dokladny K, 2010, CELL STRESS CHAPERON, V15, P153, DOI 10.1007/s12192-009-0129-6
   Dorrello NV, 2006, SCIENCE, V314, P467, DOI 10.1126/science.1130276
   Eslam M, 2020, GASTROENTEROLOGY, V158, P1999, DOI 10.1053/j.gastro.2019.11.312
   Goedeke L, 2019, ANNU REV PHARMACOL, V59, P65, DOI 10.1146/annurev-pharmtox-010716-104727
   Gupta S, 2010, PLOS BIOL, V8, DOI 10.1371/journal.pbio.1000410
   Ha BG, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0102095
   Hay N, 2004, GENE DEV, V18, P1926, DOI 10.1101/gad.1212704
   Hernández-Gea V, 2012, GASTROENTEROLOGY, V142, P938, DOI 10.1053/j.gastro.2011.12.044
   Hölttä-Vuori M, 2010, BIOCHEM J, V429, P235, DOI 10.1042/BJ20100293
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   Jensen T, 2018, J HEPATOL, V68, P1063, DOI 10.1016/j.jhep.2018.01.019
   Jung CH, 2010, FEBS LETT, V584, P1287, DOI 10.1016/j.febslet.2010.01.017
   Kim I, 2008, NAT REV DRUG DISCOV, V7, P1013, DOI 10.1038/nrd2755
   Kim JY, 2018, CELL, V175, P133, DOI 10.1016/j.cell.2018.08.020
   Lee KJ, 2004, CELL STRESS CHAPERON, V9, P58, DOI 10.1379/1466-1268(2004)009<0058:IOMCIC>2.0.CO;2
   Li S, 2011, AM J PATHOL, V179, P2822, DOI 10.1016/j.ajpath.2011.08.013
   Li SP, 2016, J NUTR BIOCHEM, V27, P96, DOI 10.1016/j.jnutbio.2015.08.021
   Mahzari A, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.00405
   Musso G, 2018, GASTROENTEROLOGY, V155, P282, DOI 10.1053/j.gastro.2018.06.031
   Musso G, 2016, NAT REV DRUG DISCOV, V15, P249, DOI 10.1038/nrd.2015.3
   Oka Takehiko, 2010, BMC Physiol, V10, P21, DOI 10.1186/1472-6793-10-21
   Peterson TR, 2011, CELL, V146, P408, DOI 10.1016/j.cell.2011.06.034
   Rai RC, 2020, LIFE SCI, V253, DOI 10.1016/j.lfs.2020.117727
   Ran G, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0180865
   Rao Y, 2019, BRIT J PHARMACOL, V176, P2877, DOI 10.1111/bph.14713
   Ren LP, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030816
   Rinella ME, 2015, JAMA-J AM MED ASSOC, V313, P2263, DOI 10.1001/jama.2015.5370
   Romero-Gómez M, 2017, J HEPATOL, V67, P829, DOI 10.1016/j.jhep.2017.05.016
   Sapp V, 2014, HEPATOLOGY, V60, P1581, DOI 10.1002/hep.27284
   Saxton RA, 2017, CELL, V168, P960, DOI [10.1016/j.cell.2017.02.004, 10.1016/j.cell.2017.03.035]
   Singh R, 2009, NATURE, V458, P1131, DOI 10.1038/nature07976
   Sinha RA, 2014, HEPATOLOGY, V59, P1366, DOI 10.1002/hep.26667
   Softic S, 2017, J CLIN INVEST, V127, P4059, DOI 10.1172/JCI94585
   Spengler EK, 2015, MAYO CLIN PROC, V90, P1233, DOI 10.1016/j.mayocp.2015.06.013
   Sun RQ, 2015, BBA-MOL BASIS DIS, V1852, P156, DOI 10.1016/j.bbadis.2014.11.017
   Suzuki A, 2017, ANNU REV MED, V68, P85, DOI 10.1146/annurev-med-051215-031109
   Turner N, 2016, TRENDS PHARMACOL SCI, V37, P379, DOI 10.1016/j.tips.2016.01.007
   Verfaillie Tom, 2010, Int J Cell Biol, V2010, P930509, DOI 10.1155/2010/930509
   Wang H, 2016, FASEB J, V30, P2549, DOI 10.1096/fj.201500119
   Wang H, 2015, ENDOCRINOLOGY, V156, P169, DOI 10.1210/en.2014-1454
   Yang L, 2010, CELL METAB, V11, P467, DOI 10.1016/j.cmet.2010.04.005
   Yim WWY, 2020, CELL DISCOV, V6, DOI 10.1038/s41421-020-0141-7
   Younossi Z, 2019, HEPATOLOGY, V69, P2672, DOI 10.1002/hep.30251
   Younossi Z, 2018, NAT REV GASTRO HEPAT, V15, P11, DOI 10.1038/nrgastro.2017.109
   Yu L, 2020, CELL RES, V30, P553, DOI 10.1038/s41422-020-0361-2
   Yu L, 2010, NATURE, V465, P942, DOI 10.1038/nature09076
   Zachari M, 2017, ESSAYS BIOCHEM, V61, P585, DOI 10.1042/EBC20170021
   Zeng XY, 2015, BRIT J PHARMACOL, V172, P4303, DOI 10.1111/bph.13209
   Zhang KZ, 2015, FRONT GENET, V5, DOI 10.3389/fgene.2014.00460
   Zhang LJ, 2016, CELL REP, V14, P1206, DOI 10.1016/j.celrep.2015.12.095
   Zhou JH, 2020, HEPATOLOGY, V71, P1851, DOI 10.1002/hep.31150
   Zhou X, 2020, NUTRIENTS, V12, DOI 10.3390/nu12092626
   Zhou X, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.01151
NR 60
TC 26
Z9 28
U1 3
U2 32
PU NATURE PUBL GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1671-4083
EI 1745-7254
J9 ACTA PHARMACOL SIN
JI Acta Pharmacol. Sin.
PD JAN
PY 2022
VL 43
IS 1
BP 10
EP 14
DI 10.1038/s41401-021-00629-0
EA MAR 2021
PG 5
WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA YA0WH
UT WOS:000629887300001
PM 33731774
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Pompili, M
   Venturini, P
   Campi, S
   Seretti, ME
   Montebovi, F
   Lamis, DA
   Serafini, G
   Amore, M
   Girardi, P
AF Pompili, Maurizio
   Venturini, Paola
   Campi, Sandra
   Seretti, Maria E.
   Montebovi, Franco
   Lamis, Dorian A.
   Serafini, Gianluca
   Amore, Mario
   Girardi, Paolo
TI Do Stroke Patients have an Increased Risk of Developing Suicidal
   Ideation or Dying by Suicide? An Overview of the Current Literature
SO CNS NEUROSCIENCE & THERAPEUTICS
LA English
DT Review
DE Intervention; Poststroke depression; Prevention; Stroke; Suicide
ID BIPOLAR-DISORDER; METABOLIC SYNDROME; MAJOR DEPRESSION; MEDICAL ILLNESS;
   POPULATION; ASSOCIATION; DISEASE; SCHIZOPHRENIA; HYPERTENSION;
   PREVALENCE
AB Stroke is a leading cause of death that affects 15 million people worldwide each year. Increasing evidence suggests that stroke confers substantial risk for suicide and following a stroke, patients frequently develop poststroke depression, which is a well-established risk factor for suicide. In this overview of the current literature, we examined the association between suffering a stroke and subsequent risk for suicide and suicidal ideation. We performed a careful MedLine, Excerpta Medica, PsycLit, PsycInfo, and Index Medicus search to identify all articles and book chapters in English. We initially selected 31 articles published between 1990 and 2011; however, only 16 studies were included in this review. All articles identified stroke as a significant risk factor for suicide, especially among depressed patients, providing further support for poststroke depression and suicidality. The results also indicated that there were differences between patients who developed acute-onset suicidal plans and those who reported delayed-onset plans, which occurred more frequently. Many of the stroke patients who died by suicide suffered from depression prior to their death, suggesting that being diagnosed with a mood disorder contributes to an increased risk of suicide in this population. Suffering from a stroke increases the risk of dying by suicide and developing suicidal ideation, particularly in young adults and women. The factors found to confer the most risk for suicidality were depression, previous mood disorder, prior history of stroke, and cognitive impairment.
C1 [Pompili, Maurizio; Seretti, Maria E.; Serafini, Gianluca; Girardi, Paolo] Univ Roma La Sapienza, St Andrea Hosp, Suicide Prevent Ctr, Dept Neurosci Mental Hlth & Sensory Organs, I-00189 Rome, Italy.
   [Pompili, Maurizio] Harvard Univ, McLean Hosp, Sch Med, Belmont, MA USA.
   [Venturini, Paola; Campi, Sandra; Montebovi, Franco] Univ Roma La Sapienza, Fac Med & Psychol, Psychiat Residency Program, I-00189 Rome, Italy.
   [Lamis, Dorian A.] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA.
   [Amore, Mario] Univ Parma, Sect Psychiat, Dept Neurosci, I-43100 Parma, Italy.
C3 Sapienza University Rome; Azienda Ospedaliera Sant'Andrea; Harvard
   University; Harvard University Medical Affiliates; McLean Hospital;
   Sapienza University Rome; Emory University; University of Parma
RP Pompili, M (corresponding author), Univ Roma La Sapienza, St Andrea Hosp, Suicide Prevent Ctr, Dept Neurosci Mental Hlth & Sensory Organs, 1035-1039 Via Grottarossa, I-00189 Rome, Italy.
EM maurizio.pompili@uniroma1.it
RI Altamura, Mario/IQS-2773-2023; Lamis, Dorian/AAM-3651-2020; Pompili,
   Maurizio/AAC-1011-2019; Serafini, Gianluca/K-6603-2016
OI Lamis, Dorian/0000-0001-5405-0239; Pompili,
   Maurizio/0000-0003-1886-4977; Serafini, Gianluca/0000-0002-6631-856X
CR [Anonymous], Web of Science Query
   [Anonymous], 2004, ATLAS HEART DIS STRO
   Arciniegas David B., 2002, Curr Treat Options Neurol, V4, P457, DOI 10.1007/s11940-002-0013-5
   Beekman ATF, 1998, SOC PSYCH PSYCH EPID, V33, P463, DOI 10.1007/s001270050080
   Birkenaes AB, 2007, J CLIN PSYCHIAT, V68, P917, DOI 10.4088/JCP.v68n0614
   Cassidy F, 1999, AM J PSYCHIAT, V156, P1417
   *CDCP, 2002, BURD CHRON DIS THEIR
   Chan SS, 2007, AM J GERIAT PSYCHIAT, V15, P541, DOI 10.1097/JGP.0b013e31803c5523
   Conwell Y, 2008, PSYCHIAT CLIN N AM, V31, P333, DOI 10.1016/j.psc.2008.01.004
   Daseking M, 2008, FORTSCHR NEUROL PSYC, V76, P662, DOI 10.1055/s-2008-1038262
   Davis J, 2008, AM J MANAG CARE, V14, P125
   Eaton WW, 1996, DIABETES CARE, V19, P1097, DOI 10.2337/diacare.19.10.1097
   Ellis C, 2010, J PSYCHOSOM RES, V68, P545, DOI 10.1016/j.jpsychores.2009.11.006
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   Fiedorowicz JG, 2008, ANN CLIN PSYCHIATRY, V20, P131, DOI 10.1080/10401230802177722
   Fleminger S, 2003, NEUROPSYCHOL REHABIL, V13, P65, DOI 10.1080/09602010244000354
   Forsström E, 2010, J NEUROPSYCH CLIN N, V22, P182, DOI 10.1176/appi.neuropsych.22.2.182
   Fuller-Thomson E, 2012, INT J STROKE, V7, P188, DOI 10.1111/j.1747-4949.2011.00702.x
   GARDEN FH, 1990, ARCH PHYS MED REHAB, V71, P1003
   Golden SH, 2008, JAMA-J AM MED ASSOC, V299, P2751, DOI 10.1001/jama.299.23.2751
   Hadidi N, 2009, HEART LUNG, V38, P151, DOI 10.1016/j.hrtlng.2008.05.002
   Harris EC, 1997, BRIT J PSYCHIAT, V170, P205, DOI 10.1192/bjp.170.3.205
   Hawton K, 2009, LANCET, V373, P1372, DOI [10.1016/S0140-6736(09)60372-X, 10.1016/S0140-6736(13)62118-2]
   Johannessen L, 2006, J AFFECT DISORDERS, V95, P13, DOI 10.1016/j.jad.2006.03.027
   Juurlink DN, 2004, ARCH INTERN MED, V164, P1179, DOI 10.1001/archinte.164.11.1179
   Katayama M, 2010, KOBE J MED SCI, V56, P184
   Kilbourne AM, 2004, BIPOLAR DISORD, V6, P368, DOI 10.1111/j.1399-5618.2004.00138.x
   Kishi Y, 1996, J NERV MENT DIS, V184, P274, DOI 10.1097/00005053-199605000-00002
   Kishi Y, 1996, Int Psychogeriatr, V8, P623, DOI 10.1017/S1041610296002931
   Kouwenhoven SE, 2011, INT J QUAL STUD HEAL, V6, DOI 10.3402/qhw.v6i4.8491
   MACKENZIE TB, 1987, INT J PSYCHIAT MED, V17, P3
   McElroy SL, 2002, J CLIN PSYCHIAT, V63, P207, DOI 10.4088/JCP.v63n0306
   Meyer CM, 2004, J AFFECT DISORDERS, V83, P127, DOI 10.1016/j.jad.2004.06.004
   Mezuk B, 2008, AM J PUBLIC HEALTH, V98, P1480, DOI 10.2105/AJPH.2007.126441
   Mukherjee D, 2011, WORLD NEUROSURG, V76, pS85, DOI 10.1016/j.wneu.2011.07.023
   Patten SB, 2008, GEN HOSP PSYCHIAT, V30, P407, DOI 10.1016/j.genhosppsych.2008.05.001
   Placido A, 2009, INT J CARDIOL, V135, P261, DOI 10.1016/j.ijcard.2008.03.034
   Pohjasvaara T, 2001, CEREBROVASC DIS, V12, P21, DOI 10.1159/000047676
   Pompili Maurizio, 2004, Ann Ist Super Sanita, V40, P475
   Pompili M, 2012, COMPR PSYCHIAT, V53, P280, DOI 10.1016/j.comppsych.2011.04.004
   Pompili M, 2012, J AFFECT DISORDERS, V136, P405, DOI 10.1016/j.jad.2011.11.011
   Pompili M, 2009, EXPERT REV NEUROTHER, V9, P985, DOI [10.1586/ern.09.62, 10.1586/ERN.09.62]
   Pritchard C, 2005, INT J GERIATR PSYCH, V20, P17, DOI 10.1002/gps.1213
   Quan H, 2002, SOC PSYCH PSYCH EPID, V37, P190, DOI 10.1007/s001270200014
   Rao R, 1999, STROKE, V30, P2167, DOI 10.1161/01.STR.30.10.2167
   Santos CO, 2012, J STROKE CEREBROVASC, V21, P749, DOI 10.1016/j.jstrokecerebrovasdis.2011.04.001
   Saravane D, 2009, ENCEPHALE, V35, P330, DOI 10.1016/j.encep.2008.10.014
   Scott KM, 2010, PSYCHOSOM MED, V72, P712, DOI 10.1097/PSY.0b013e3181e3333d
   Shah Amy, 2006, Ann Clin Psychiatry, V18, P239, DOI 10.1080/10401230600948423
   Stenager EN, 1998, BRIT MED J, V316, P1206, DOI 10.1136/bmj.316.7139.1206
   Tang WK, 2011, ARCH PHYS MED REHAB, V92, P1336, DOI 10.1016/j.apmr.2011.02.018
   Teasdale TW, 2001, J EPIDEMIOL COMMUN H, V55, P863, DOI 10.1136/jech.55.12.863
   Voaklander DC, 2008, J EPIDEMIOL COMMUN H, V62, P138, DOI 10.1136/jech.2006.055533
   Williams LS, 2005, SEMIN NEUROL, V25, P396, DOI 10.1055/s-2005-923534
   YATES WR, 1987, J AFFECT DISORDERS, V12, P129, DOI 10.1016/0165-0327(87)90004-8
NR 55
TC 84
Z9 89
U1 1
U2 16
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1755-5930
J9 CNS NEUROSCI THER
JI CNS Neurosci. Ther.
PY 2012
VL 18
IS 9
BP 711
EP 721
DI 10.1111/j.1755-5949.2012.00364.x
PG 11
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 999CU
UT WOS:000308287500001
PM 22943140
OA Green Published
DA 2025-06-11
ER

PT J
AU Boyle, SH
   Jackson, WG
   Suarez, EC
AF Boyle, Stephen H.
   Jackson, William G.
   Suarez, Edward C.
TI Hostility, anger, and depression predict increases in C3 over a 10-year
   period
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE complement; hostility; anger; depression; men
ID ADRENERGIC-RECEPTOR RESPONSIVENESS; ACUTE MYOCARDIAL-INFARCTION;
   CORONARY-HEART-DISEASE; COMPLEMENT C3; REACTIVE PROTEIN; PLASMA
   INTERLEUKIN-6; INSULIN-RESISTANCE; METABOLIC SYNDROME; BLOOD MONOCYTES;
   RISK-FACTORS
AB We examined the relation of hostility, anger, and depression to 10-year changes in the third (C3), and fourth (C4) complement in 313, apparently healthy male participants enrolled in the Air Force Health Study (AFHS), a 20-year study designed to evaluate the health co sequences of dioxin exposure. Hostility, depression, and anger were assessed using subscales from the Minnesota Multiphasic Personality Inventory (MMPI), which was administered in 1985. Given the high intercorrelations among these psychological scales, we used a principal component analysis to generate a composite score representing the linear combination of the hostility, anger, and depression scales. The dependent variables, C3 and C4 levels, were determined from samples collected in 1992, 1997, and 2002. Regression analyses controlling for age, race, alcohol use, body mass index, and cigarette use as well as onset of disease, and use of lipid lowering and blood pressure medications during follow-up revealed a significant time x composite score interaction for C3 complement (p <.0003), but not C4. Post-hoc analyses revealed that high composite scores were associated with larger 10-year increases in C3. These observations suggest that men who are hostile and are prone to experience frequent and intense feelings of anger, and depression show activation of the complement system, and specifically increases in C3, that may contribute to the development of coronary heart disease. (C) 2007 Elsevier Inc. All rights reserved.
C1 Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27710 USA.
   USAF, Res Lab, Brooks City Base, TX USA.
C3 Duke University; United States Department of Defense; United States Air
   Force
RP Boyle, SH (corresponding author), Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, POB 3328, Durham, NC 27710 USA.
EM boyle020@mc.duke.edu; suare001@mc.duke.edu
RI Suarez, Edward/HPE-3092-2023
OI Suarez, Edward/0000-0003-3069-5846
FU NHLBI NIH HHS [HL67459, R01 HL067459] Funding Source: Medline
CR Ahmad K, 2000, LANCET, V355, P1621, DOI 10.1016/S0140-6736(05)72527-7
   [Anonymous], 1993, COMPLEMENT HLTH DIS
   Arroyo C, 2004, DIABETES CARE, V27, P129, DOI 10.2337/diacare.27.1.129
   BALDO A, 1993, J CLIN INVEST, V92, P1543, DOI 10.1172/JCI116733
   Barefoot J C, 1997, Cardiologia, V42, P1245
   BAREFOOT JC, 1995, AM J EPIDEMIOL, V142, P477, DOI 10.1093/oxfordjournals.aje.a117663
   BAREFOOT JC, 1989, PSYCHOSOM MED, V51, P46, DOI 10.1097/00006842-198901000-00005
   Barefoot JC, 2001, PSYCHOL AGING, V16, P342, DOI 10.1037//0882-7974.16.2.342
   Barefoot JC, 1996, CIRCULATION, V93, P1976, DOI 10.1161/01.CIR.93.11.1976
   Barnes PJ, 1997, NEW ENGL J MED, V336, P1066, DOI 10.1056/NEJM199704103361506
   Berk M, 1997, J PSYCHOSOM RES, V43, P529, DOI 10.1016/S0022-3999(97)00139-6
   Bierhaus A, 2003, P NATL ACAD SCI USA, V100, P1920, DOI 10.1073/pnas.0438019100
   Black PH, 2003, BRAIN BEHAV IMMUN, V17, P350, DOI 10.1016/S0889-1591(03)00048-5
   BONHALL LR, 1995, CLIN LAB SCI, V8, P80
   Cook WW, 1954, J APPL PSYCHOL, V38, P414, DOI 10.1037/h0060667
   Dernellis J, 2006, AM J CARDIOL, V97, P245, DOI 10.1016/j.amjcard.2005.08.027
   Di Napoli M, 2001, STROKE, V32, P1444, DOI 10.1161/01.STR.32.6.1443-a
   Engström G, 2005, DIABETES, V54, P570, DOI 10.2337/diabetes.54.2.570
   Everson SA, 1998, PSYCHOSOM MED, V60, P730, DOI 10.1097/00006842-199811000-00014
   FALUS A, 1990, MOL IMMUNOL, V27, P197, DOI 10.1016/0161-5890(90)90115-G
   Ferketich AK, 2000, ARCH INTERN MED, V160, P1261, DOI 10.1001/archinte.160.9.1261
   FIGUEREDO A, 1993, DIABETES CARE, V16, P445, DOI 10.2337/diacare.16.2.445
   Graham JE, 2006, BRAIN BEHAV IMMUN, V20, P389, DOI 10.1016/j.bbi.2005.11.002
   Huerta R, 1995, PSYCHONEUROENDOCRINO, V20, P851, DOI 10.1016/0306-4530(95)00030-5
   Hughes JW, 2003, PSYCHOSOM MED, V65, P582, DOI 10.1097/01.PSY.0000041546.04128.43
   JARAV H, 1999, I IMMUNOL, V163, P3957
   KRONFOL Z, 1989, ACTA PSYCHIAT SCAND, V80, P142, DOI 10.1111/j.1600-0447.1989.tb01316.x
   KULICS J, 1990, J CLIN INVEST, V85, P943, DOI 10.1172/JCI114523
   Light KC, 1998, INT J PSYCHOPHYSIOL, V28, P157, DOI 10.1016/S0167-8760(97)00093-7
   Maes M, 1997, PSYCHONEUROENDOCRINO, V22, P397, DOI 10.1016/S0306-4530(97)00042-5
   Miller GE, 2002, AM J CARDIOL, V90, P1279, DOI 10.1016/S0002-9149(02)02863-1
   MUSCARI A, 1995, AM J MED, V98, P357, DOI 10.1016/S0002-9343(99)80314-3
   Muscari A, 2000, EUR HEART J, V21, P1081, DOI 10.1053/euhj.1999.2013
   Onat A, 2005, CLIN SCI, V108, P129, DOI 10.1042/CS20040198
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Ritchie RF, 2004, J CLIN LAB ANAL, V18, P1, DOI 10.1002/jcla.10100
   *SAS I, 1999, SAS STAT US VERS 8
   Schafer JL, 2002, PSYCHOL METHODS, V7, P147, DOI 10.1037//1082-989X.7.2.147
   Siegman AW, 2000, AM J CARDIOL, V86, P145, DOI 10.1016/S0002-9149(00)00850-X
   SONG C, 1994, J AFFECT DISORDERS, V30, P283, DOI 10.1016/0165-0327(94)90135-X
   SPIVAK B, 1989, BIOL PSYCHIAT, V26, P640, DOI 10.1016/0006-3223(89)90091-7
   Suarez EC, 2004, PSYCHOSOM MED, V66, P684, DOI 10.1097/01.psy.0000138281.73634.67
   Suarez EC, 1997, PSYCHOSOM MED, V59, P481, DOI 10.1097/00006842-199709000-00004
   Suarez EC, 2003, PSYCHOSOM MED, V65, P523, DOI 10.1097/01.PSY.0000062530.94551.EA
   Suarez EC, 2003, BRAIN BEHAV IMMUN, V17, P296, DOI 10.1016/S0889-1591(03)00059-X
   Suarez EC, 2003, PSYCHOSOM MED, V65, P362, DOI 10.1097/01.PSY.0000035719.79068.2B
   Suarez EC, 2002, BRAIN BEHAV IMMUN, V16, P675, DOI 10.1016/S0889-1591(02)00019-3
   Suarez EC, 1998, PSYCHOSOM MED, V60, P78, DOI 10.1097/00006842-199801000-00017
   Suarez EC, 1998, J PSYCHOSOM RES, V44, P261, DOI 10.1016/S0022-3999(97)00201-8
   Suarez EC, 2006, BRAIN BEHAV IMMUN, V20, P331, DOI 10.1016/j.bbi.2005.09.005
   Surwit RS, 2002, DIABETES CARE, V25, P835, DOI 10.2337/diacare.25.5.835
   van Oostrom AJHHM, 2007, ATHEROSCLEROSIS, V190, P167, DOI 10.1016/j.atherosclerosis.2006.01.009
   Wahle M, 2005, J INTERF CYTOK RES, V25, P384, DOI 10.1089/jir.2005.25.384
   Watkins LR, 1999, ADV EXP MED BIOL, V461, P153
   Weyer C, 2000, DIABETES CARE, V23, P779, DOI 10.2337/diacare.23.6.779
   WIENER DN, 1948, J CONSULT PSYCHOL, V12, P164, DOI 10.1037/h0055594
   WOLFE WH, 1990, JAMA-J AM MED ASSOC, V264, P1824, DOI 10.1001/jama.264.14.1824
   Yasojima K, 2001, AM J PATHOL, V158, P1039, DOI 10.1016/S0002-9440(10)64051-5
   Ylitalo K, 1997, ATHEROSCLEROSIS, V129, P271, DOI 10.1016/S0021-9150(96)06054-6
   ZIMMER B, 1982, EUR J IMMUNOL, V12, P426, DOI 10.1002/eji.1830120513
   Zung W. W. K., 1986, ZUNG SELF RATING DEP
NR 61
TC 37
Z9 48
U1 0
U2 7
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD AUG
PY 2007
VL 21
IS 6
BP 816
EP 823
DI 10.1016/j.bbi.2007.01.008
PG 8
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA 196SG
UT WOS:000248501700012
PM 17321106
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Locke, B
   Lu, R
AF Locke, Briana
   Lu, Ray
TI Establishment of immortalized porcine intramuscular preadipocytes for
   the study of lipid metabolism
SO BIOCHEMISTRY AND CELL BIOLOGY
LA English
DT Article
DE intramuscular preadipocytes; adipogenesis; lipid metabolism; endoplasmic
   reticulum stress; CREB3
ID UNFOLDED PROTEIN RESPONSE; STRESS-RESPONSE; ADIPOSE-TISSUE; GOLGI
   STRESS; FAT; DIFFERENTIATION; TRANSCRIPTION; ADIPOGENESIS; STEATOSIS;
   PATHWAY
AB Intramuscular adipose tissue is associated with an increased risk for the development of metabolic syndrome. A cellular model of adipogenesis in muscular tissues would be an invaluable tool for studying regulatory factors in this important process. Cellular stress can impact the homeostasis of various metabolic pathways, including lipid metabolism. In this study, a porcine intramuscular preadipocyte cell line was established, which displayed mature adipocyte attributes such as lipid accumulation and increased expression of adipogenic gene markers. Since it is well established that endoplasmic reticulum (ER) and Golgi stress impact adipogenesis, we sought to investigate the effects of ER/Golgi stress and an associated protein, CREB3, in this cell line model. We found that this novel model maintains robust adipogenic capabilities, and that ER stress can negatively affect adipogenic markers. Overall, these findings demonstrate the strength of the new cell model for studying adipogenesis, and highlight the impact of ER stress on lipid metabolism.
C1 [Locke, Briana; Lu, Ray] Univ Guelph, Dept Mol & Cellular Biol, Guelph, ON, Canada.
C3 University of Guelph
RP Lu, R (corresponding author), Univ Guelph, Dept Mol & Cellular Biol, Guelph, ON, Canada.
EM ray.lu@uoguelph.ca
FU Mitacs Accelerate Program; Ontario Genomics; Agricultural Adaptation
   Council; Genome Canada [ON-RP3]
FX This work was supported by the Mitacs Accelerate Program, and Ontario
   Genomics, the Agricultural Adaptation Council, and Genome Canada under
   the Ontario Regional Priorities Partnership Program (ON-RP3) .
CR ASO H, 1995, BIOCHEM BIOPH RES CO, V213, P369, DOI 10.1006/bbrc.1995.2141
   Basseri S, 2012, BIOCHEM RES INT, V2012, DOI 10.1155/2012/841362
   Bassols A, 2014, PROTEOM CLIN APPL, V8, P715, DOI 10.1002/prca.201300099
   Boden G, 2008, DIABETES, V57, P2438, DOI 10.2337/db08-0604
   Camp HS, 2002, TRENDS MOL MED, V8, P442, DOI 10.1016/S1471-4914(02)02396-1
   Chen FF, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18102101
   Cheng YM, 2023, COMMUN BIOL, V6, DOI 10.1038/s42003-023-05583-7
   Counter CM, 1998, P NATL ACAD SCI USA, V95, P14723, DOI 10.1073/pnas.95.25.14723
   Darimont C, 2003, BIOCHIMIE, V85, P1231, DOI 10.1016/j.biochi.2003.10.015
   DenBoer LM, 2005, BIOCHEM BIOPH RES CO, V331, P113, DOI 10.1016/j.bbrc.2005.03.141
   Ghaben AL, 2019, NAT REV MOL CELL BIO, V20, P242, DOI 10.1038/s41580-018-0093-z
   HALBERT CL, 1991, J VIROL, V65, P473, DOI 10.1128/JVI.65.1.473-478.1991
   He PP, 2018, CLIN CHIM ACTA, V480, P126, DOI 10.1016/j.cca.2018.02.006
   Hong Peng-cheng, 2023, Journal of Nanjing Agricultural University, V46, P128, DOI 10.7685/jnau.202112023
   Ingram KH, 2011, OBESITY, V19, P1469, DOI 10.1038/oby.2011.45
   Kim JY, 2020, MOL CELL BIOCHEM, V468, P97, DOI 10.1007/s11010-020-03714-w
   Kim TH, 2014, CELL DEATH DIS, V5, DOI 10.1038/cddis.2014.490
   Lee JE, 2019, MOL CELL BIOL, V39, DOI 10.1128/MCB.00601-18
   Liang GQ, 2006, MOL CELL BIOL, V26, P7999, DOI 10.1128/MCB.01046-06
   Locke B, 2024, FEBS LETT, V598, P1730, DOI 10.1002/1873-3468.14897
   Lowe CE, 2012, INT J OBESITY, V36, P1248, DOI 10.1038/ijo.2011.233
   Lu R, 1997, MOL CELL BIOL, V17, P5117, DOI 10.1128/MCB.17.9.5117
   Morrison S, 2015, ADIPOCYTE, V4, P295, DOI 10.1080/21623945.2015.1040612
   Namwanje M, 2019, J ENDOCRINOL, V240, P257, DOI [10.1530/joe-18-0361, 10.1530/JOE-18-0361]
   Oh-Hashi K, 2021, MOL CELL BIOCHEM, V476, P3869, DOI 10.1007/s11010-021-04187-1
   Oyadomari S, 2008, CELL METAB, V7, P520, DOI 10.1016/j.cmet.2008.04.011
   Penney J, 2018, FRONT MOL NEUROSCI, V11, DOI 10.3389/fnmol.2018.00352
   Rajesh RV, 2010, COMP BIOCHEM PHYS D, V5, P234, DOI 10.1016/j.cbd.2010.06.004
   Reddy JK, 2001, ANNU REV NUTR, V21, P193, DOI 10.1146/annurev.nutr.21.1.193
   Reiling JH, 2013, NAT CELL BIOL, V15, P1473, DOI 10.1038/ncb2865
   Rutkowski DT, 2008, DEV CELL, V15, P829, DOI 10.1016/j.devcel.2008.10.015
   Sarr O, 2016, BIOTECHNIQUES, V61, P233, DOI 10.2144/000114471
   Sasaki K, 2019, FEBS LETT, V593, P2330, DOI 10.1002/1873-3468.13554
   Savage DB, 2007, PHYSIOL REV, V87, P507, DOI 10.1152/physrev.00024.2006
   SCHURMANN A, 1994, J BIOL CHEM, V269, P15683
   Smith BS, 2023, MITOCHONDRION, V69, P10, DOI 10.1016/j.mito.2023.01.001
   Smith BS, 2022, INT J OBESITY, V46, P1446, DOI 10.1038/s41366-022-01128-w
   Strable MS, 2010, CRIT REV BIOCHEM MOL, V45, P199, DOI 10.3109/10409231003667500
   Sun YM, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18112424
   Takahashi N, 2002, J BIOL CHEM, V277, P16906, DOI 10.1074/jbc.M200585200
   Tchkonia T, 2002, AM J PHYSIOL-REG I, V282, pR1286, DOI 10.1152/ajpregu.00653.2001
   Tchkonia T, 2010, AGING CELL, V9, P667, DOI 10.1111/j.1474-9726.2010.00608.x
   Therkelsen KE, 2013, ARTERIOSCL THROM VAS, V33, P863, DOI 10.1161/ATVBAHA.112.301009
   Tripathi M, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21051645
   Yamamoto K, 2010, MOL BIOL CELL, V21, P2975, DOI 10.1091/mbc.E09-02-0133
NR 45
TC 0
Z9 0
U1 0
U2 0
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 123 Slater Street, Suite 610, OTTAWA, ON K1P 5H2, CANADA
SN 0829-8211
EI 1208-6002
J9 BIOCHEM CELL BIOL
JI Biochem. Cell Biol.
PY 2025
VL 103
AR 0174
DI 10.1139/bcb-2024-0174
PG 11
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 1PM2J
UT WOS:001470558500001
PM 40127467
DA 2025-06-11
ER

PT J
AU Lanza, GA
   Filice, M
   De Vita, A
   Villano, A
   Manfredonia, L
   Lamendola, P
   Crea, F
AF Lanza, Gaetano A.
   Filice, Monica
   De Vita, Antonio
   Villano, Angelo
   Manfredonia, Laura
   Lamendola, Priscilla
   Crea, Filippo
TI Microvascular Angina - Long-Term Exercise Stress Test Follow-up
SO CIRCULATION JOURNAL
LA English
DT Article
DE Clinical outcome; Exercise stress test; Follow-up; Microvascular angina
ID CARDIAC SYNDROME-X; CHEST-PAIN; CLINICAL CHARACTERISTICS; SENSITIVITY;
   DYSFUNCTION
AB Background: A sizeable proportion of patients with primary stable microvascular angina (MVA; exercise-induced angina, positive exercise stress test [ EST], normal coronary arteries) have recurrent symptoms during follow-up. There have been no previous studies, however, on the long-term results of EST and their correlation with symptom outcome.
   Methods and Results: Follow-up EST was performed in 71 MVA patients at an average of 16.2 years (range, 5-25 years) from the first EST. Angina status was assessed on weekly frequency of angina episodes and nitroglycerin consumption and by whether symptoms had worsened, improved, or remained unchanged over time. At follow-up EST, 41 patients (group 1) had exercise-induced ischemia, whereas 30 patients (group 2) had negative EST. Compared to group 2, group 1 patients more frequently had exercise-induced dyspnea, and had a greater maximum ST-segment depression and a lower coronary blood flow response to adenosine and cold pressor test, but group 2 patients had a more frequent history of rest angina. No differences between the 2 groups were found at follow-up in angina status or change in symptom status during follow-up.
   Conclusions: Electrocardiogram results improve significantly in a sizeable proportion of patients with MVA. Changes in EST results, however, were not associated with clinical outcome.
C1 [Lanza, Gaetano A.; Filice, Monica; De Vita, Antonio; Villano, Angelo; Manfredonia, Laura; Lamendola, Priscilla; Crea, Filippo] Univ Cattolica Sacro Cuore, Univ Hosp Policlin A Gemelli Fdn, Inst Cardiol, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Lanza, GA (corresponding author), Univ Cattolica Sacro Cuore, Ist Cardiol, Largo A Gemelli 8, I-00168 Rome, Italy.
EM gaetanoantonio.lanza@unicatt.it
RI De Vita, Antonio/LRC-4736-2024; Crea, Filippo/AAC-9754-2022; Filice,
   Monica/GZM-7376-2022; Villano, Angelo/AAC-7245-2022; Lanza,
   Gaetano/AAC-2660-2019
OI Villano, Angelo/0000-0003-1651-1369; De Vita,
   Antonio/0000-0001-8725-7447
CR CANNON RO, 1990, J AM COLL CARDIOL, V16, P1359, DOI 10.1016/0735-1097(90)90377-2
   Crea F, 2017, EUR HEART J, V38, P473, DOI 10.1093/eurheartj/ehw461
   Di Monaco A, 2010, AM J CARDIOL, V106, P1813, DOI 10.1016/j.amjcard.2010.07.052
   KASKI JC, 1995, J AM COLL CARDIOL, V25, P807, DOI 10.1016/0735-1097(94)00507-M
   Lamendola P, 2010, INT J CARDIOL, V140, P197, DOI 10.1016/j.ijcard.2008.11.026
   Lanza GA, 2017, CIRCULATION, V135, P1982, DOI 10.1161/CIRCULATIONAHA.117.027685
   Lanza GA, 2010, CIRCULATION, V121, P2317, DOI 10.1161/CIRCULATIONAHA.109.900191
   LICHTLEN PR, 1995, J AM COLL CARDIOL, V25, P1013, DOI 10.1016/0735-1097(94)00519-V
   Ohba K, 2012, J AM HEART ASSOC, V1, DOI 10.1161/JAHA.112.002485
   Pasceri V, 1998, J AM COLL CARDIOL, V31, P62, DOI 10.1016/S0735-1097(97)00421-X
   Paulus WJ, 2013, J AM COLL CARDIOL, V62, P263, DOI 10.1016/j.jacc.2013.02.092
   Suzuki H, 2002, CIRC J, V66, P691, DOI 10.1253/circj.66.691
   Valeriani M, 2005, EUR HEART J, V26, P975, DOI 10.1093/eurheartj/ehi229
NR 13
TC 3
Z9 3
U1 0
U2 0
PU JAPANESE CIRCULATION SOC
PI TOYKO
PA 18TH FLOOR IMPERIAL HOTEL TOWER, 1-1-1 UCHISAIWAI-CHO CHIYODA-KU, TOYKO,
   100-0011, JAPAN
SN 1346-9843
EI 1347-4820
J9 CIRC J
JI Circ. J.
PD APR
PY 2018
VL 82
IS 4
BP 1070
EP 1075
DI 10.1253/circj.CJ-17-0657
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GA1MB
UT WOS:000428079000020
PM 28890527
OA gold
DA 2025-06-11
ER

PT J
AU Weber-Hamann, B
   Hentschel, F
   Kniest, A
   Deuschle, M
   Colla, M
   Lederbogen, F
   Heuser, I
AF Weber-Hamann, B
   Hentschel, F
   Kniest, A
   Deuschle, M
   Colla, M
   Lederbogen, F
   Heuser, I
TI Hypercortisolemic depression is associated with increased
   intra-abdominal fat
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE major depression; hypercortisolemia; visceral fat; insulin resistance
ID MAJOR DEPRESSION; OBESITY; TESTOSTERONE; CORTISOL; DISEASE
AB Objective: Similar to patients with a metabolic syndrome, patients with major depression are at increased risk of developing cardiovascular disorders. Interestingly, both disorders share a specific endocrine syndrome that promotes the accumulation of visceral fat, which again is considered a marker of increased cardiovascular morbidity and mortality. Methods: Intra-abdominal fat was measured in 22 postmenopausal depressed women and 23 age-matched healthy women by computer tomography at the level of lumbar vertebrae 1 (L1) and 4 (L4). Saliva was taken in patients and control subjects at 08:00 hours over a period of 7 drug-free days for the measurement of free cortisol. In patients only we performed an oral glucose tolerance test. Results: Compared with control subjects, depressed patients with elevated free cortisol concentrations showed similar visceral fat depots at L1 (113.0 +/- 41.6 vs. 94.3 +/- 53.2 cm(2)). Hypercortisolemic depressed patients also showed greater fat depots in this area (74.5 +/- 55.5 cm(2), p =.04) than the normocortisolemic patients. However, a comparison of all patients with control subjects revealed no difference in fat accumulation at either L1 or L4. Finally, glucose concentrations during the glucose tolerance test were higher in hypercortisolemic than in normocortisolemic patients, whereas their insulin levels showed only a tendency toward being increased. Conclusions: Hvpercortisolemic depressed patients suffer from resistance to insulin and increased visceral fat. The fact that hypercortisolemia reverses depression-related fat loss, particularly in the visceral area, might partially explain why major depression can be considered a risk factor for cardiovascular disorders.
C1 Free Univ Berlin, Univ Hosp Benjamin Franklin, Dept Psychiat, D-14050 Berlin, Germany.
   Cent Inst Mental Hlth, D-6800 Mannheim, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Central
   Institute of Mental Health
RP Heuser, I (corresponding author), Free Univ Berlin, Univ Hosp Benjamin Franklin, Dept Psychiat, Eschenallee 3, D-14050 Berlin, Germany.
RI Deuschle, Michael/E-4638-2012; Colla, Michael/G-1458-2010
OI Heuser, Isabella/0000-0001-7075-1158
CR *AM PSYCH ASS, 1994, DSM IV DIAGN STAT MA
   Björntorp P, 1999, DRUGS, V58, P13
   Bjorntorp P, 1996, INT J OBESITY, V20, P291
   Bjorntorp P, 1993, Obes Res, V1, P206
   BUFFINGTON CK, 1994, METABOLISM, V43, P584, DOI 10.1016/0026-0495(94)90200-3
   Bujalska IJ, 1997, LANCET, V349, P1210, DOI 10.1016/S0140-6736(96)11222-8
   Glassman AH, 1998, AM J PSYCHIAT, V155, P4, DOI 10.1176/ajp.155.1.4
   HAARBO J, 1991, METABOLISM, V40, P323
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Heuser I, 1998, PHARMACOPSYCHIATRY, V31, P10, DOI 10.1055/s-2007-979288
   KAPLAN NM, 1989, ARCH INTERN MED, V149, P1514, DOI 10.1001/archinte.149.7.1514
   KIRSCHBAUM C, 1989, NEUROPSYCHOBIOLOGY, V22, P150, DOI 10.1159/000118611
   REBUFFESCRIVE M, 1990, J CLIN ENDOCR METAB, V71, P1215, DOI 10.1210/jcem-71-5-1215
   ROY M, 1990, PSYCHIAT RES, V31, P31, DOI 10.1016/0165-1781(90)90106-F
   Schweiger U, 1999, PSYCHOSOM MED, V61, P292, DOI 10.1097/00006842-199905000-00007
   Steiger A, 1997, SLEEP, V20, P1038
   Thakore JH, 1997, BIOL PSYCHIAT, V41, P1140, DOI 10.1016/S0006-3223(97)85394-2
   Weber B, 2000, PSYCHONEUROENDOCRINO, V25, P765, DOI 10.1016/S0306-4530(00)00023-8
   Weber B, 2000, EXP CLIN ENDOCR DIAB, V108, P187, DOI 10.1055/s-2000-7742
   WINOKUR A, 1988, AM J PSYCHIAT, V145, P325
NR 20
TC 162
Z9 184
U1 1
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0033-3174
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD MAR-APR
PY 2002
VL 64
IS 2
BP 274
EP 277
DI 10.1097/00006842-200203000-00010
PG 4
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 533VU
UT WOS:000174551600010
PM 11914443
DA 2025-06-11
ER

PT J
AU Becarevic, M
   Burgic, E
AF Becarevic, Munevera
   Burgic, Esad
TI Cardiovascular risk factors in Banovici coal mine miners
SO HEALTHMED
LA English
DT Article
DE cardiovascular risk; arterial hypertension; metabolical syndrome;
   depression; miners
ID HIGH-DENSITY-LIPOPROTEINS; METABOLIC SYNDROME; WAIST CIRCUMFERENCE;
   UNITED-STATES; NATIONAL-HEALTH; BLOOD-PRESSURE; GLOBAL BURDEN;
   PREVALENCE; DEPRESSION; DISEASE
AB Global cardiovascular risk is probability to suffer heart attack or stroke in certain period of life and it depends on risk factors (RF) such as metabolical factors (total cholesterol, HDL cholesterol, glucoses metabolism disturbance), some biological factors (blood pressure) and some life style factors (smoking, physical activity).
   The aim of this research is to determine the presence and tendency of certain cardio vascular (CV) risk factors (RF) as well as determination of hypertension prevalence, metabolical syndrome and depression among coal-miners in Banovici black coal mine.
   Materials and methods: epidemiological study was conducted on 492 miners actively involved in working in mine pits. The analasys covered the following values: blood pressure, height and weight, BMI, waist, concentrations of total cholesterol, HDL and LDL cholesterol, triglycerides, blood sugar, determination of smoking status along with depression score based on Beks' scale.
   According to NCEP ATP III criteria MS is defined. The results are as follows: 43.9% out of 492 testers have high blood pressure, 34,34% are with depression, 42,88% are with MS. The most frequent risk factors are high BMI (75,40%), high values of LDL-H (70,32%). The most of hypertensive miners had six (23,61%), and normotensive three (21,73%) risk factors.
   Conclusion: there is high prevalence of diagnosing from hypertension, metabolical syndrome and depression with expressed tendency of risk factors grouping with high BMI as the most frequent one along with the high values of LDL cholesterol.
C1 [Becarevic, Munevera] Publ Hlth Ctr Banovici, Dept Occupat Med, Banovici, Bosnia & Herceg.
   [Burgic, Esad] Publ Hlth Ctr Lukavac, Dept Lab Diagnost, Biochem Hematol Lab, Clin Internal Dis, Lukavac, Bosnia & Herceg.
RP Becarevic, M (corresponding author), Publ Hlth Ctr Banovici, Dept Occupat Med, Banovici, Bosnia & Herceg.
EM munevera.b@gmail.com
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alboni P, 2008, J CARDIOVASC MED, V9, P356, DOI 10.2459/JCM.0b013e3282785240
   Assmann G, 2007, AM J CARDIOL, V99, P541, DOI 10.1016/j.amjcard.2006.08.045
   Atreya A, 2010, INT J COLLAB RES INT, V2, P280
   Becarevic M, 2009, HEALTHMED, V3, P273
   Bennet A, 2008, ARCH INTERN MED, V168, P598, DOI 10.1001/archinte.168.6.598
   Brotman DJ, 2007, LANCET, V370, P1089, DOI 10.1016/S0140-6736(07)61305-1
   Califf RM, 1996, J AM COLL CARDIOL, V27, P1007, DOI 10.1016/0735-1097(96)87733-3
   Choy CS, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-613
   De Backer G, 2003, EUR HEART J, V24, P1601, DOI 10.1016/S0195-668X(03)00347-6
   Dong YJ, DEPRESSION RISK STRO
   Fan AZ, 2008, PREV MED, V46, P445, DOI 10.1016/j.ypmed.2008.02.016
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Genovesi S, 2008, J HYPERTENS, V26, P1563, DOI 10.1097/HJH.0b013e328302842b
   Greenland P, 2010, J AM COLL CARDIOL, V56, P2182, DOI 10.1016/j.jacc.2010.09.002
   Hirschler V, 2005, ARCH PEDIAT ADOL MED, V159, P740, DOI 10.1001/archpedi.159.8.740
   Hirschler V, 2007, DIABETES TECHNOL THE, V9, P149, DOI 10.1089/dia.2006.0017
   Hu G, 2010, CIRCULATION, V121, P237, DOI 10.1161/CIRCULATIONAHA.109.887893
   Kearney PM, 2005, LANCET, V365, P217, DOI 10.1016/S0140-6736(05)70151-3
   Khot UN, 2003, JAMA-J AM MED ASSOC, V290, P898, DOI 10.1001/jama.290.7.898
   Kolcic I, 2006, CROAT MED J, V47, P585
   Lawes CMM, 2006, J HYPERTENS, V24, P413, DOI 10.1097/01.hjh.0000199801.72563.6f
   Lewis GF, 2005, CIRC RES, V96, P1221, DOI 10.1161/01.RES.0000170946.56981.5c
   Lj Hotujac, 2003, DEPRESIJA PREPOZNAVA, P10
   Maffeis C, 2008, J PEDIATR-US, V152, P207, DOI 10.1016/j.jpeds.2007.09.021
   Mancia G, 2003, J HYPERTENS, V21, P1011, DOI 10.1097/01.hjh.0000059051.65882.32
   Mineo C, 2006, CIRC RES, V98, P1352, DOI 10.1161/01.RES.0000225982.01988.93
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Negre-Salvayre A, 2006, FREE RADICAL BIO MED, V41, P1031, DOI 10.1016/j.freeradbiomed.2006.07.006
   Novakovic B, 2011, INT J COLLABORATIVE, V3, P220
   Onat A, 2007, INT J OBESITY, V31, P1119, DOI 10.1038/sj.ijo.0803552
   Ong KL, 2007, HYPERTENSION, V49, P69, DOI 10.1161/01.HYP.0000252676.46043.18
   Raison CL, 2006, TRENDS IMMUNOL, V27, P24, DOI 10.1016/j.it.2005.11.006
   Reaven G, 2002, CIRCULATION, V106, P286, DOI 10.1161/01.CIR.0000019884.36724.D9
   Rutter MK, 2011, EUR HEART J, V32, P2247, DOI 10.1093/eurheartj/ehr154
   Serban C, 2011, INT J COLLAB RES INT, V3, P733
   Shah AJ, 2011, ARCH GEN PSYCHIAT, V68, P1135, DOI 10.1001/archgenpsychiatry.2011.125
   Shim RS, 2011, J AM BOARD FAM MED, V24, P33, DOI 10.3122/jabfm.2011.01.100121
   Steptoe A, 2007, DEPRESSION AND PHYSICAL ILLNESS, P1, DOI 10.2277/ 0521603609
   Tanyolaç S, 2009, METAB SYNDR RELAT D, V7, P543, DOI 10.1089/met.2009.0027
   Tso C, 2006, ARTERIOSCL THROM VAS, V26, P1144, DOI 10.1161/01.ATV.0000216600.37436.cf
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
   Valderrama Amy L., 2011, Morbidity and Mortality Weekly Report, V60, P1248
   Wassink AMJ, 2011, DIABETIC MED, V28, P932, DOI 10.1111/j.1464-5491.2011.03318.x
NR 44
TC 0
Z9 1
U1 1
U2 2
PU DRUNPP-SARAJEVO
PI SARAJEVO
PA BOLNICKA BB, SARAJEVO, 71000, BOSNIA & HERCEG
SN 1840-2291
EI 1986-8103
J9 HEALTHMED
JI HealthMED
PY 2012
VL 6
IS 3
BP 1067
EP 1075
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 926GK
UT WOS:000302819100053
DA 2025-06-11
ER

PT J
AU Park, SK
   Chung, Y
   Chang, YS
   Oh, CM
   Ryoo, JH
   Jung, JY
AF Park, Sung Keun
   Chung, Yeongu
   Chang, Yoosoo
   Oh, Chang-Mo
   Ryoo, Jae-Hong
   Jung, Ju Young
TI Longitudinal analysis for the risk of depression according to the
   consumption of sugar-sweetened carbonated beverage in non-diabetic and
   diabetic population
SO SCIENTIFIC REPORTS
LA English
DT Article
ID SOFT DRINK CONSUMPTION; METABOLIC SYNDROME; INDEX; QUESTIONNAIRE;
   METAANALYSIS; ASSOCIATION; FRUCTOSE; GLUCOSE; OBESITY; ADULTS
AB Studies have presented that high intake of sugar-sweetened carbonated beverage (SSCB) was more associated with the prevalence of depression. However, longitudinal evidence is still insufficient to identify whether the effect of SSCB on incident depression is independent of metabolic factors. Therefore, to evaluate the effect of SSCB consumption on the risk of depression, we analyzed the risk of depression according to the consumption of SSCB in 87,115 working aged Koreans who responded to Center for Epidemiologic Studies Depression (CES-D) scale. They were categorized into 5 groups by SSCB consumption based on one serving dose (200 ml) with never/almost never, < 1 serving/week, 1 <= serving/week < 3, 3 <= serving/week < 5, and 5 <= serving/week. During follow-up, CES-D >= 16 was determined as incident depressive symptom. Cox proportional hazards model was used to calculate the multivariable-adjusted hazard ratio (HR) and 95% confidence intervals (CI) for depressive symptom. In analysis for all study participants, the risk of depressive symptom significantly increased proportionally to SSCB consumption (never/ almost never: reference, < 1 serving/week: 1.12 [1.07-1.17], 1 <= similar to < 3 serving/week: 1.26 [1.19-1.33], 3 <= similar to < 5 serving/week: 1.32 [1.23-1.42], and >= 5 serving/week: 1.45 [1.33-1.59]). This association was identically observed in men, women, normal glycemic subgroup and prediabetes subgroup.
C1 [Park, Sung Keun; Chang, Yoosoo] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Ctr Cohort Studies, Total Healthcare Ctr,Sch Med, Seoul, South Korea.
   [Chung, Yeongu] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Neurosurg, Sch Med, Seoul, South Korea.
   [Oh, Chang-Mo] Kyung Hee Univ, Sch Med, Dept Prevent Med, Seoul, South Korea.
   [Ryoo, Jae-Hong] Kyung Hee Univ, Sch Med, Dept Occupat & Environm Med, Seoul, South Korea.
   [Jung, Ju Young] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Total Healthcare Ctr, Sch Med, 67 Sejong Daero, Seoul 04514, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Sungkyunkwan
   University (SKKU); Samsung Medical Center; Kyung Hee University; Kyung
   Hee University; Sungkyunkwan University (SKKU)
RP Jung, JY (corresponding author), Sungkyunkwan Univ, Kangbuk Samsung Hosp, Total Healthcare Ctr, Sch Med, 67 Sejong Daero, Seoul 04514, South Korea.
EM jjy0501@naver.com
RI Jung, Ju/L-1569-2019
CR Ahn Y, 2007, EUR J CLIN NUTR, V61, P1435, DOI 10.1038/sj.ejcn.1602657
   Ahn Y, 2003, Nutr Sci, V6, P173
   [Anonymous], 2016, DIABETES CARE, V39, pS1, DOI [10.2337/dc19-Sint01, 10.2337/dc16-S001, 10.2337/dc19-SINT01, 10.2337/dc20-Sint, 10.2337/dc20-SINT]
   Bromet E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-90
   Butnoriene J, 2014, PSYCHONEUROENDOCRINO, V40, P269, DOI 10.1016/j.psyneuen.2013.11.002
   Chakraborti A, 2021, FRONT NEUROSCI-SWITZ, V15, DOI 10.3389/fnins.2021.669410
   Chen SG, 2016, ENDOCRINE, V53, P35, DOI 10.1007/s12020-016-0869-x
   Cho MJ, 1998, J NERV MENT DIS, V186, P304, DOI 10.1097/00005053-199805000-00007
   de Koning L, 2012, CIRCULATION, V125, P1735, DOI 10.1161/CIRCULATIONAHA.111.067017
   Ferrari AJ, 2013, PSYCHOL MED, V43, P471, DOI 10.1017/S0033291712001511
   Guo XG, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094715
   Harrell CS, 2015, PSYCHONEUROENDOCRINO, V62, P252, DOI 10.1016/j.psyneuen.2015.08.025
   Hu DQ, 2019, J AFFECT DISORDERS, V245, P348, DOI 10.1016/j.jad.2018.11.015
   Kan C, 2013, DIABETES CARE, V36, P480, DOI 10.2337/dc12-1442
   Kang D, 2018, EUR J CLIN NUTR, V72, P1506, DOI 10.1038/s41430-018-0121-2
   Kassebaum NJ, 2016, LANCET, V388, P1603, DOI 10.1016/S0140-6736(16)31460-X
   Knüppel A, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-05649-7
   Lasserre AM, 2014, JAMA PSYCHIAT, V71, P880, DOI 10.1001/jamapsychiatry.2014.411
   Lee CH, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.01696
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Malik VS, 2010, DIABETES CARE, V33, P2477, DOI 10.2337/dc10-1079
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McInnis CM, 2014, BRAIN BEHAV IMMUN, V42, P33, DOI 10.1016/j.bbi.2014.07.018
   Oh JY, 2007, KOREAN J FAM MED, V28, P532
   Park SK, 2022, EPIDEMIOL HEALTH, V44, DOI 10.4178/epih.e2022062
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Sanchez-Villegas A, 2018, BRIT J NUTR, V119, P211, DOI 10.1017/S0007114517003361
   Schulze MB, 2004, JAMA-J AM MED ASSOC, V292, P927, DOI 10.1001/jama.292.8.927
   Schulze MB, 2004, AM J CLIN NUTR, V80, P348, DOI 10.1093/ajcn/80.2.348
   Shi ZM, 2010, PUBLIC HEALTH NUTR, V13, P1073, DOI 10.1017/S1368980009993132
   Stanhope KL, 2008, AM J CLIN NUTR, V88, p1733S, DOI 10.3945/ajcn.2008.25825D
   The Korean Nutrition Society, 2005, CAN PRO 3 0 SOFTW
   Webb M, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0187448
   Yu B, 2015, J AFFECT DISORDERS, V172, P422, DOI 10.1016/j.jad.2014.10.026
NR 34
TC 1
Z9 1
U1 1
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 9
PY 2023
VL 13
IS 1
AR 12901
DI 10.1038/s41598-023-40194-6
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA O7LF4
UT WOS:001045574100012
PM 37558774
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Shin, D
   Pregenzer, G
   Gardin, JM
AF Shin, David
   Pregenzer, Gerard, Jr.
   Gardin, Julius M.
TI Erectile Dysfunction A Disease Marker for Cardiovascular Disease
SO CARDIOLOGY IN REVIEW
LA English
DT Review
DE erectile dysfunction; cardiovascular disease; coronary artery disease
ID CORONARY-ARTERY-DISEASE; RISK-FACTORS; SEXUAL DYSFUNCTION; METABOLIC
   SYNDROME; HEART-DISEASE; INTERNATIONAL INDEX; CARDIAC RISK; PREVALENCE;
   POPULATION; CALCIUM
AB Previous studies have shown an increased incidence of erectile dysfunction (ED) among patients diagnosed with cardiovascular disease (CVD). Both conditions, which may be a consequence of underlying endothelial dysfunction, share many risk factors such as hypertension, dyslipidemia, diabetes, depression, obesity, and cigarette smoking. Because vascular disturbance of the penile endothelium leads to ED, the possibility arises that ED may be an early indicator for systemic endothelial dysfunction and subsequent CVD. Recognizing ED as a disease marker for CVD may help to identify individuals at risk for having a premature cardiovascular event.
C1 [Shin, David] Hackensack Univ, Med Ctr, Dept Urol, Hackensack, NJ 07601 USA.
   [Pregenzer, Gerard, Jr.] Univ Med & Dent New Jersey, Newark, NJ 07103 USA.
   [Gardin, Julius M.] Hackensack Univ, Med Ctr, Dept Internal Med, Hackensack, NJ USA.
C3 Hackensack University Medical Center; Rutgers University System; Rutgers
   University New Brunswick; Rutgers University Biomedical & Health
   Sciences; Hackensack University Medical Center
RP Shin, D (corresponding author), Hackensack Univ, Med Ctr, Dept Urol, 360 Essex St,Ste 403, Hackensack, NJ 07601 USA.
EM dshin@humed.com
CR ANDERSSON KE, 1995, PHYSIOL REV, V75, P191, DOI 10.1152/physrev.1995.75.1.191
   Arad Y, 2000, J AM COLL CARDIOL, V36, P1253, DOI 10.1016/S0735-1097(00)00872-X
   Araujo AB, 2010, J AM COLL CARDIOL, V55, P350, DOI 10.1016/j.jacc.2009.08.058
   Aytac IA, 1999, BJU INT, V84, P50
   Bacon CG, 2003, ANN INTERN MED, V139, P161, DOI 10.7326/0003-4819-139-3-200308050-00005
   Bal K, 2007, UROLOGY, V69, P356, DOI 10.1016/j.urology.2006.09.057
   Barrett-Connor E, 2005, AM J CARDIOL, V96, p3M, DOI 10.1016/j.amjcard.2005.07.012
   Billups KL, 2008, INT J IMPOT RES, V20, P236, DOI 10.1038/sj.ijir.3901634
   Bortolotti A, 1997, INT J ANDROL, V20, P323
   Burke JP, 2007, J UROLOGY, V177, P1438, DOI 10.1016/j.juro.2006.11.059
   Cappelleri JC, 1999, UROLOGY, V54, P346, DOI 10.1016/S0090-4295(99)00099-0
   Cartledge J, 2001, Expert Opin Pharmacother, V2, P95, DOI 10.1517/14656566.2.1.95
   Chew KK, 2010, J SEX MED, V7, P192, DOI 10.1111/j.1743-6109.2009.01576.x
   Chiurlia E, 2005, J AM COLL CARDIOL, V46, P1503, DOI 10.1016/j.jacc.2005.06.068
   Cooke JP, 2000, VASC MED, V5, P49, DOI 10.1177/1358836X0000500108
   Demir T, 2006, INT J UROL, V13, P385, DOI 10.1111/j.1442-2042.2006.01310.x
   Derby CA, 2000, INT J IMPOT RES, V12, P197, DOI 10.1038/sj.ijir.3900542
   Detrano RC, 2000, CURR PROB CARDIOLOGY, V25, P374, DOI 10.1067/mcd.2000.104848
   Donovan JL, 1996, BRIT J UROL, V77, P554, DOI 10.1046/j.1464-410X.1996.93013.x
   DROLLER MJ, 1993, JAMA-J AM MED ASSOC, V270, P83
   Esposito K, 2005, INT J IMPOT RES, V17, P391, DOI 10.1038/sj.ijir.3901333
   Feldman HA, 2000, PREV MED, V30, P328, DOI 10.1006/pmed.2000.0643
   FELDMAN HA, 1994, J UROLOGY, V151, P54, DOI 10.1016/S0022-5347(17)34871-1
   Gades NM, 2005, AM J EPIDEMIOL, V161, P346, DOI 10.1093/aje/kwi052
   Gazzaruso C, 2004, CIRCULATION, V110, P22, DOI 10.1161/01.CIR.0000133278.81226.C9
   Gazzaruso C, 2008, J AM COLL CARDIOL, V51, P2040, DOI 10.1016/j.jacc.2007.10.069
   Giuliano FA, 2004, UROLOGY, V64, P1196, DOI 10.1016/j.urology.2004.08.059
   Greenland P, 2004, JAMA-J AM MED ASSOC, V291, P210, DOI 10.1001/jama.291.2.210
   Greenstein A, 1997, INT J IMPOT RES, V9, P123, DOI 10.1038/sj.ijir.3900282
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Guay AT, 2007, ENDOCRIN METAB CLIN, V36, P453, DOI 10.1016/j.ecl.2007.03.007
   Inman BA, 2009, MAYO CLIN PROC, V84, P108, DOI 10.4065/84.2.108
   Jackson G, 2008, INT J IMPOT RES, V20, pS1, DOI 10.1038/ijir.2008.45
   Jackson G, 2006, J SEX MED, V3, P28, DOI 10.1111/j.1743-6109.2005.00196.x
   Jeremy JY, 2000, CARDIOVASC RES, V46, P50, DOI 10.1016/S0008-6363(00)00009-2
   Jones R W A, 2002, Expert Opin Pharmacother, V3, P889
   Kalter-Leibovici O, 2005, DIABETES CARE, V28, P1739, DOI 10.2337/diacare.28.7.1739
   Kirby M, 2001, INT J CLIN PRACT, V55, P614
   Klein R, 1996, DIABETES CARE, V19, P135, DOI 10.2337/diacare.19.2.135
   Kostis JB, 2005, AM J CARDIOL, V96, P313, DOI 10.1016/j.amjcard.2005.03.065
   Lue TF, 2000, NEW ENGL J MED, V342, P1802, DOI 10.1056/NEJM200006153422407
   Ma RCW, 2008, J AM COLL CARDIOL, V51, P2045, DOI 10.1016/j.jacc.2008.02.051
   Marx Nikolaus, 2007, Diab Vasc Dis Res, V4, P82
   Matfin Glenn, 2005, Curr Diab Rep, V5, P64, DOI 10.1007/s11892-005-0070-8
   MCCULLOCH DK, 1980, DIABETOLOGIA, V18, P279
   McCullough Andrew R, 2003, Rev Urol, V5 Suppl 7, pS3
   Montorsi P, 2003, EUR UROL, V44, P352, DOI 10.1016/S0302-2838(03)00307-5
   Montorsi P, 2006, EUR HEART J, V27, P2632, DOI 10.1093/eurheartj/ehl142
   Montorsi P, 2006, EUR UROL, V50, P721, DOI 10.1016/j.eururo.2006.07.015
   Mykletun A, 2006, BJU INT, V97, P316, DOI 10.1111/j.1464-410X.2005.05904.x
   Nikoobakht M, 2005, INT J IMPOT RES, V17, P523, DOI 10.1038/sj.ijir.3901350
   Ponholzer A, 2005, EUR UROL, V48, P512, DOI 10.1016/j.eururo.2005.05.014
   Ponholzer A, 2005, EUR UROL, V47, P80, DOI 10.1016/j.eururo.2004.08.017
   Rehman J, 2001, CURR CLIN UROL, P1
   Rodriguez JJ, 2005, INT J IMPOT RES, V17, pS12, DOI 10.1038/sj.ijir.3901424
   Rosen RC, 1999, INT J IMPOT RES, V11, P319, DOI 10.1038/sj.ijir.3900472
   Roth A, 2003, CLIN CARDIOL, V26, P25, DOI 10.1002/clc.4960260106
   Saigal CS, 2006, ARCH INTERN MED, V166, P207, DOI 10.1001/archinte.166.2.207
   Sangiorgi G, 1998, J AM COLL CARDIOL, V31, P126, DOI 10.1016/S0735-1097(97)00443-9
   Schmermund Axel, 2003, Cardiology Clinics, V21, P521, DOI 10.1016/S0733-8651(03)00088-2
   Schouten BWV, 2008, INT J IMPOT RES, V20, P92, DOI 10.1038/sj.ijir.3901604
   Solomon H, 2003, AM J CARDIOL, V91, P230, DOI 10.1016/S0002-9149(02)03113-2
   Teloken P, 2006, J SEX MED, V3, P778, DOI 10.1111/j.1743-6109.2006.00286.x
   Thompson IM, 2005, JAMA-J AM MED ASSOC, V294, P2996, DOI 10.1001/jama.294.23.2996
   Ulzheimer S, 2003, EUR RADIOL, V13, P484, DOI 10.1007/s00330-002-1746-y
   VIRAG R, 1985, LANCET, V1, P181
   WEI M, 1994, AM J EPIDEMIOL, V140, P930, DOI 10.1093/oxfordjournals.aje.a117181
   Yaman O, 2008, INT UROL NEPHROL, V40, P117, DOI 10.1007/s11255-007-9293-8
NR 68
TC 58
Z9 66
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1061-5377
EI 1538-4683
J9 CARDIOL REV
JI Cardiol. Rev.
PD JAN-FEB
PY 2011
VL 19
IS 1
BP 5
EP 11
DI 10.1097/CRD.0b013e3181fb7eb8
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 690YB
UT WOS:000285045100002
PM 21135596
DA 2025-06-11
ER

PT J
AU De Fruyt, J
   Deschepper, E
   Audenaert, K
   Constant, E
   Floris, M
   Pitchot, W
   Sienaert, P
   Souery, D
   Claes, S
AF De Fruyt, Juergen
   Deschepper, Ellen
   Audenaert, Kurt
   Constant, Eric
   Floris, Michel
   Pitchot, William
   Sienaert, Pascal
   Souery, Daniel
   Claes, Stephan
TI Second generation antipsychotics in the treatment of bipolar depression:
   a systematic review and meta-analysis
SO JOURNAL OF PSYCHOPHARMACOLOGY
LA English
DT Review
DE Bipolar disorder; meta-analysis; depressive episode; placebo; second
   generation antipsychotics
ID OLANZAPINE-FLUOXETINE COMBINATION; WEEKLY SYMPTOMATIC STATUS;
   DOUBLE-BLIND; II DEPRESSION; OLANZAPINE/FLUOXETINE COMBINATION;
   QUETIAPINE MONOTHERAPY; METABOLIC SYNDROME; NATURAL-HISTORY; DISORDER;
   EFFICACY
AB Depressive symptoms and episodes dominate the course of bipolar disorder. However, the therapeutic armamentarium for bipolar depression is limited. Recent evidence points to the efficacy of second generation antipsychotics (SGAs) for the treatment of bipolar depression. We conducted a systematic review and meta-analysis of the efficacy and safety of SGAs (randomized, double-blind, placebo-controlled trials; used in monotherapy) in the treatment of adult patients with bipolar depression. Publication bias was corrected for by performing similar searches using the clinical trials register of the respective pharmaceutical companies, the Cochrane Database and ClinicalTrials.gov. Seven published papers were identified on the use of aripiprazole, olanzapine and quetiapine. Internal validity of the trials was fairly good, external validity only moderate. Different outcome measures of efficacy and safety were assessed. When the individual trials were looked at, quetiapine and to a lesser extent olanzapine demonstrated significant improvement in MADRS (Montgomery-Asberg Depression Rating Scale) total scores. This was not demonstrated for aripiprazole. Efficacy was hampered by adverse events, such as weight gain, akathisia and somnolence/sedation. Both clinical heterogeneity of the included trials and statistical heterogeneity of the meta-analytic data were considerable. The number of quetiapine trials was disproportionate to the number of trials of aripiprazole and olanzapine. Further research is needed to assess differential efficacy of the different SGAs and their use in clinical practice.
C1 [De Fruyt, Juergen] Gen Hosp Sint Jan Brugge Oostende AV, Dept Psychiat, B-8000 Brugge, Belgium.
   [De Fruyt, Juergen; Claes, Stephan] Catholic Univ Louvain, Univ Psychiat Ctr, B-3000 Louvain, Belgium.
   [Deschepper, Ellen] Univ Ghent, Belgium Biostat Unit, B-9000 Ghent, Belgium.
   [Deschepper, Ellen] Univ Ghent, Dept Appl Math Biometr & Proc Control, B-9000 Ghent, Belgium.
   [Deschepper, Ellen; Audenaert, Kurt] Univ Ghent, Dept Psychiat & Med Psychol, B-9000 Ghent, Belgium.
   [Constant, Eric] Catholic Univ Louvain, Dept Psychiat, Woluwe St Lambert, Belgium.
   [Floris, Michel] Hop Notre Dame de Bon Secours, Dept Psychiat, Tournai, Belgium.
   [Pitchot, William] Univ Liege, Dept Psychiat, CHU Liege, Liege, Belgium.
   [Sienaert, Pascal] Katholieke Univ Leuven, Univ Psychiat Ctr, Kortenberg, Belgium.
   [Souery, Daniel] Univ Libre Bruxelles, Lab Psychol Med, Brussels, Belgium.
   [Souery, Daniel] Psy Pluriel European Ctr Psychol Med, Uccle, Belgium.
C3 Universite Catholique Louvain; Ghent University; Ghent University; Ghent
   University; Universite Catholique Louvain; University of Liege; KU
   Leuven; Universite Libre de Bruxelles
RP De Fruyt, J (corresponding author), Gen Hosp Sint Jan Brugge Oostende AV, Dept Psychiat & Psychosomat, Ruddershove 10, B-8000 Brugge, Belgium.
EM jurgendefruyt@skynet.be
RI Sienaert, Pascal/K-1838-2012
OI Claes, Stephan/0000-0002-1175-492X; Sienaert, Pascal/0000-0002-0650-415X
FU AstraZeneca Belgium; AstraZeneca; Boehringer Ingelheim; BristolMyers
   Squibb; Eli Lilly and Company; GlaxoSmithKline; JanssenCilag; Lundbeck;
   Pfizer; Servier; Wyeth; Nycomed; Solvay; Novartis; Fonds de la Recherche
   Scientifique; European Commission; Johnson Johnson
FX Funding for this meta-analysis was provided by AstraZeneca
   Belgium.Jurgen De Fruyt has been a consultant for, received honoraria or
   scientific/educational grant from, or conducted clinical research
   supported by the following: AstraZeneca, Boehringer Ingelheim,
   BristolMyers Squibb, Eli Lilly and Company, GlaxoSmithKline,
   JanssenCilag, Lundbeck, Pfizer, Servier and Wyeth.Michel Floris has been
   a consultant for, received honoraria or scientific/educational grant
   from, or conducted clinical research supported by the following:
   AstraZeneca, Eli Lilly and Company, Janssen-Cilag, Lundbeck and
   Nycomed.William Pitchot has been a consultant for, received honoraria or
   scientific/educational grant from, or conducted clinical research
   supported by the following: AstraZeneca, Bristol-Myers Squibb, Eli Lilly
   and Company, GlaxoSmithKline, Janssen-Cilag, Lundbeck, Novartis, Pfizer,
   Servier, Solvay and Wyeth.Daniel Souery has been a consultant for,
   received honoraria or scientific/educational grant from, or conducted
   clinical research supported by the following: AstraZeneca, Bristol-Myers
   Squibb, Janssen-Cilag, Lundbeck, Fonds de la Recherche Scientifique and
   European Commission.Stephan Claes has been a consultant for, received
   honoraria or scientific/educational grant from, or conducted clinical
   research supported by the following: AstraZeneca, Bristol-Myers Squibb,
   Eli Lilly and Company, Johnson & Johnson, GlaxoSmithKline and Wyeth.
   Stephan Claes is a Senior Clinical Investigator of the Fund for
   Scientific Research - Flanders (FWO - Vlaanderen).
CR Amsterdam JD, 2005, J AFFECT DISORDERS, V87, P121, DOI 10.1016/j.jad.2005.02.018
   [Anonymous], BIPOLAR DEPRESSION C
   Brown EB, 2006, J CLIN PSYCHIAT, V67, P1025, DOI 10.4088/JCP.v67n0703
   Calabrese JR, 2005, J CLIN PSYCHIAT, V66, P26
   Calabrese JR, 2005, AM J PSYCHIAT, V162, P1351, DOI 10.1176/appi.ajp.162.7.1351
   Cookson J, 2007, INT CLIN PSYCHOPHARM, V22, P93, DOI 10.1097/YIC.0b013e3280119dfb
   Correll CU, 2008, BIPOLAR DISORD, V10, P788, DOI 10.1111/j.1399-5618.2008.00625.x
   Corya SA, 2006, J CLIN PSYCHIAT, V67, P798, DOI 10.4088/JCP.v67n0514
   Cousins DA, 2007, INT J NEUROPSYCHOPH, V10, P411, DOI 10.1017/S1461145706007413
   Cruz N, 2010, INT J NEUROPSYCHOPH, V13, P5, DOI 10.1017/S1461145709990344
   De Fruyt J, 2007, PSYCHOTHER PSYCHOSOM, V76, P77, DOI 10.1159/000097966
   Derry S, 2007, BMC PSYCHIATRY, V7, DOI 10.1186/1471-244X-7-40
   Endicott J, 2007, INT CLIN PSYCHOPHARM, V22, P29
   Fagiolini A, 2008, CNS DRUGS, V22, P655, DOI 10.2165/00023210-200822080-00004
   Geddes JR, 2009, BRIT J PSYCHIAT, V194, P4, DOI 10.1192/bjp.bp.107.048504
   Ghaemi SN, 2003, BIPOLAR DISORD, V5, P421, DOI 10.1046/j.1399-5618.2003.00074.x
   Healy D, 2009, TRANSCULT PSYCHIATRY, V46, P16, DOI 10.1177/1363461509102285
   Hirschfeld RMA, 2006, J CLIN PSYCHIAT, V67, P355, DOI 10.4088/JCP.v67n0304
   Jadad AR, 1996, CONTROL CLIN TRIALS, V17, P1, DOI 10.1016/0197-2456(95)00134-4
   Judd LL, 2002, ARCH GEN PSYCHIAT, V59, P530, DOI 10.1001/archpsyc.59.6.530
   Judd LL, 2003, ARCH GEN PSYCHIAT, V60, P261, DOI 10.1001/archpsyc.60.3.261
   Keck PE, 2005, J CLIN PSYCHIAT, V66, P611, DOI 10.4088/JCP.v66n0511
   Keck PE, 2005, BIPOLAR DISORD, V7, P34, DOI 10.1111/j.1399-5618.2005.00213.x
   Kirsch I, 2008, PLOS MED, V5, P260, DOI 10.1371/journal.pmed.0050045
   Leucht S, 2009, LANCET, V373, P31, DOI 10.1016/S0140-6736(08)61764-X
   McElroy SL, 2010, J CLIN PSYCHIAT, V71, P163, DOI 10.4088/JCP.08m04942gre
   MONTGOMERY SA, 1979, BRIT J PSYCHIAT, V134, P382, DOI 10.1192/bjp.134.4.382
   Nemeroff CB, 2001, AM J PSYCHIAT, V158, P906, DOI 10.1176/appi.ajp.158.6.906
   Newcomer JW, 2007, J CLIN PSYCHIAT, V68, P20
   Nierenberg AA, 2006, AM J PSYCHIAT, V163, P210, DOI 10.1176/appi.ajp.163.2.210
   Papakostas GI, 2007, J CLIN PSYCHIAT, V68, P826, DOI 10.4088/JCP.v68n0602
   Petitti DB, 2001, STAT MED, V20, P3625, DOI 10.1002/sim.1091
   Posternak MA, 2007, BRIT J PSYCHIAT, V190, P287, DOI 10.1192/bjp.bp.106.028555
   Sachs GS, 2007, NEW ENGL J MED, V356, P1711, DOI 10.1056/NEJMoa064135
   Scherk H, 2007, ARCH GEN PSYCHIAT, V64, P442, DOI 10.1001/archpsyc.64.4.442
   Shelton RC, 2004, J CLIN PSYCHIAT, V65, P1715, DOI 10.4088/JCP.v65n1218
   Shi LZ, 2004, CLIN THER, V26, P125, DOI 10.1016/S0149-2918(04)90013-6
   Sienaert P, 2007, PREVENTIE BIPOLAIRE
   Suppes T, 2010, J AFFECT DISORDERS, V121, P106, DOI 10.1016/j.jad.2009.10.007
   Thase ME, 2008, J CLIN PSYCHOPHARM, V28, P13, DOI 10.1097/jcp.0b013e3181618eb4
   Thase ME, 2006, J CLIN PSYCHOPHARM, V26, P600, DOI 10.1097/01.jcp.0000248603.76231.b7
   Tohen M, 2003, ARCH GEN PSYCHIAT, V60, P1079, DOI 10.1001/archpsyc.60.11.1079
   Tohen M, 2007, J AFFECT DISORDERS, V104, P137, DOI 10.1016/j.jad.2007.03.014
   Van Lieshout RJ, 2010, BRIT J PSYCHIAT, V196, P266, DOI 10.1192/bjp.bp.108.057612
   Vieta E, 2007, BIPOLAR DISORD, V9, P413, DOI 10.1111/j.1399-5618.2007.00479.x
   Williamson D, 2006, J AFFECT DISORDERS, V92, P261, DOI 10.1016/j.jad.2006.02.011
   Yatham LN, 2009, BIPOLAR DISORD, V11, P225, DOI 10.1111/j.1399-5618.2009.00672.x
   Young AH, 2010, J CLIN PSYCHIAT, V71, P150, DOI 10.4088/JCP.08m04995gre
NR 48
TC 72
Z9 77
U1 0
U2 18
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0269-8811
EI 1461-7285
J9 J PSYCHOPHARMACOL
JI J. Psychopharmacol.
PD MAY
PY 2012
VL 26
IS 5
BP 603
EP 617
DI 10.1177/0269881111408461
PG 15
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 950PZ
UT WOS:000304662500002
PM 21940761
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Jahrami, H
   Saif, Z
   AlHaddad, M
   Faris, MA
   Hammad, L
   Ali, B
AF Jahrami, Haitham
   Saif, Zahra
   AlHaddad, Muntadher
   Faris, Mo'ez Al-Islam
   Hammad, Laila
   Ali, Batool
TI Assessing dietary and lifestyle risk behaviours and their associations
   with disease comorbidities among patients with depression: A case
   -control study from Bahrain
SO HELIYON
LA English
DT Article
DE Biological sciences; Health sciences; Cardiovascular disease;
   Depression; Dietary habits; Lifestyle behaviors; Physical activity;
   Smoking
ID INFLAMMATORY INDEX; SEDENTARY BEHAVIOR; BIPOLAR DISORDER; METABOLIC
   SYNDROME; MENTAL-ILLNESS; METAANALYSIS; SYMPTOMS; PEOPLE; PREVALENCE;
   SCHIZOPHRENIA
AB Objectives: In Western populations, patients with depression die 10 -25 years prematurely compared to controls, mainly due to lifestyle -related diseases. Tobacco smoking, excessive alcohol intake, poor diets and physical inactivity are among the major contributors to disease comorbidities. The objective of this research is to assess the dietary and lifestyle behaviours for Bahraini patients with depression and to determine their associations with different medical comorbidities. Methods: A case -control study was conducted from March to December 2019. A sample of 96 diagnosed patients with depression was recruited from the Psychiatric Hospital/Bahrain, and 96 age- and sex -matched controls were recruited from primary health centres. Assessment of anthropometrics, dietary and alcohol intakes, tobacco smoking and physical activity levels were undertaken for both cases and controls. National electronic medical records were reviewed retrospectively for medical comorbidities for the recruited cases. Logistic regression analysis was used to identify associations between lifestyle behaviours and medical comorbidities after controlling for confounding factors. Results: Patients with depression reported higher intakes of energy and energy -yielding macronutrients (e.g., carbohydrates, protein, and fat); three -fold higher rates of tobacco smoking; and signi ficantly lower levels of physical activity. Cases appeared to be at a doubled risk for developing obesity, diabetes type 2, hypertension, and musculoskeletal disorders. The risk for cardiovascular problems was similar for cases and controls. Conclusions: Poor dietary intakes, increased prevalence of smoking, and low levels of physical activity were evident in patients with depression in Bahrain; these factors were associated with some medical comorbidities.
C1 [Jahrami, Haitham; Saif, Zahra; AlHaddad, Muntadher; Hammad, Laila; Ali, Batool] Minist Hlth, Manama, Bahrain.
   [Jahrami, Haitham] Arabian Gulf Univ, Coll Med & Med Sci, Manama, Bahrain.
   [Faris, Mo'ez Al-Islam] Univ Sharjah, Res Inst Med & Hlth Sci RIMHS, Dept Clin Nutr & Dietet, Coll Hlth Sci, Sharjah, U Arab Emirates.
C3 Ministry of Health - Bahrain; Arabian Gulf University; University of
   Sharjah
RP Jahrami, H (corresponding author), Minist Hlth, Manama, Bahrain.; Jahrami, H (corresponding author), Arabian Gulf Univ, Coll Med & Med Sci, Manama, Bahrain.
EM hjahrami@health.gov.bh
RI Jahrami, Haitham/JVO-6632-2024; Faris, MoezAlIslam/M-9682-2017
OI Faris, MoezAlIslam/0000-0002-7970-2616; Jahrami,
   Haitham/0000-0001-8990-1320
CR Air T., 2016, Cardiovascular Diseases and Depression, V15, P5
   Akbaraly TN, 2016, CLIN PSYCHOL SCI, V4, P1125, DOI 10.1177/2167702616645777
   Ali MK, 2018, BAHRAIN MED B, V40, P86, DOI 10.12816/0047555
   [Anonymous], 2005, INT CLASS DIS ICD
   Baune B.T., 2016, Cardiovascular Diseases and Depression: Treatment and Prevention in Psychocardiology
   Beck AT, 1996, J PERS ASSESS, V67, P588, DOI 10.1207/s15327752jpa6703_13
   Berge LI, 2015, INT J ENDOCRINOL, V2015, DOI 10.1155/2015/164760
   Charara R, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0169575
   Charlson F, 2019, LANCET, V394, P240, DOI 10.1016/S0140-6736(19)30934-1
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   Daumit GL, 2013, NEW ENGL J MED, V368, P1594, DOI 10.1056/NEJMoa1214530
   Dent R, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0036889, 10.1371/journal.pone.0037135]
   Doyle TA, 2013, J PSYCHOSOM RES, V75, P419, DOI 10.1016/j.jpsychores.2013.08.006
   Finch LE, 2015, APPETITE, V95, P239, DOI 10.1016/j.appet.2015.07.017
   Firth J, 2019, LANCET PSYCHIAT, V6, P675, DOI 10.1016/S2215-0366(19)30132-4
   Firth J, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00350
   Firth J, 2018, WORLD PSYCHIATRY, V17, P365, DOI 10.1002/wps.20571
   Flegal KM, 2010, JAMA-J AM MED ASSOC, V303, P235, DOI 10.1001/jama.2009.2014
   Fluharty M, 2017, NICOTINE TOB RES, V19, P3, DOI 10.1093/ntr/ntw140
   Forsyth AK, 2012, AUST J PRIM HEALTH, V18, P172, DOI 10.1071/PY11023
   Gerrior Shirley, 2006, Prev Chronic Dis, V3, pA129
   Grosso G, 2016, MOL NUTR FOOD RES, V60, P223, DOI 10.1002/mnfr.201500620
   Gurillo P, 2015, LANCET PSYCHIAT, V2, P718, DOI 10.1016/S2215-0366(15)00152-2
   Hamadeh Randah R, 2016, BMC Res Notes, V9, P77, DOI 10.1186/s13104-016-1894-9
   Helou K, 2017, BMC PUBLIC HEALTH, V18, DOI 10.1186/s12889-017-4599-7
   Jahrami H., 2014, ARAB J PSYCHIAT, V25, P190
   Jahrami H, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081867
   Jahrami HA, 2017, ASIAN J PSYCHIATR, V28, P115, DOI 10.1016/j.ajp.2017.03.036
   Kang Hee-Ju, 2015, Chonnam Med J, V51, P8, DOI 10.4068/cmj.2015.51.1.8
   Köhler CA, 2017, ACTA PSYCHIAT SCAND, V135, P373, DOI 10.1111/acps.12698
   LI J, 2019, HEPATOLOGY, V4, P389, DOI DOI 10.1016/S2468-1253(19)30039-1
   Li Y, 2017, PSYCHIAT RES, V253, P373, DOI 10.1016/j.psychres.2017.04.020
   Lim GY, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-21243-x
   Lucas M, 2014, BRAIN BEHAV IMMUN, V36, P46, DOI 10.1016/j.bbi.2013.09.014
   Mitchell AJ, 2015, GEN HOSP PSYCHIAT, V37, P14, DOI 10.1016/j.genhosppsych.2014.11.006
   Moieni M, 2015, NEUROPSYCHOPHARMACOL, V40, P1709, DOI 10.1038/npp.2015.17
   Mulugeta A, 2018, BMC PSYCHIATRY, V18, DOI 10.1186/s12888-018-1877-6
   Naja S, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2019-030365
   Phillips CM, 2018, CLIN NUTR, V37, P1485, DOI 10.1016/j.clnu.2017.08.029
   Poole L, 2011, J PSYCHOSOM RES, V71, P61, DOI 10.1016/j.jpsychores.2010.12.009
   Reich M, 2008, CURR OPIN ONCOL, V20, P353, DOI 10.1097/CCO.0b013e3282fc734b
   Sánchez-Villegas A, 2015, BRIT J NUTR, V114, P1471, DOI 10.1017/S0007114515003074
   Shivappa N, 2018, J AFFECT DISORDERS, V235, P39, DOI 10.1016/j.jad.2018.04.014
   Stanaway JD, 2018, LANCET, V392, P1923, DOI 10.1016/s0140-6736(18)32225-6
   Stubbs B, 2018, J AFFECT DISORDERS, V229, P231, DOI 10.1016/j.jad.2017.12.104
   Stubbs B, 2016, AGE AGEING, V45, P228, DOI 10.1093/ageing/afw001
   Teasdale SB, 2017, BRIT J PSYCHIAT, V210, P110, DOI 10.1192/bjp.bp.115.177139
   Trafford A.M., 2019, JAMA DERMATOL
   Vancampfort D, 2018, J AFFECT DISORDERS, V234, P97, DOI 10.1016/j.jad.2018.02.088
   Vancampfort D, 2016, J AFFECT DISORDERS, V201, P145, DOI 10.1016/j.jad.2016.05.020
   Vancampfort D, 2016, WORLD PSYCHIATRY, V15, P166, DOI 10.1002/wps.20309
   Vancampfort D, 2015, DEPRESS ANXIETY, V32, P763, DOI 10.1002/da.22387
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   von Elm E, 2008, J CLIN EPIDEMIOL, V61, P344, DOI 10.2471/BLT.07.045120
   Walker ER, 2015, JAMA PSYCHIAT, V72, P334, DOI 10.1001/jamapsychiatry.2014.2502
   Wang LF, 2016, AUST NZ J PSYCHIAT, V50, P228, DOI 10.1177/0004867415603131
   WHO EMRO, 2020, WWW DOC
   Wirth MD, 2017, HEALTH PSYCHOL, V36, P760, DOI 10.1037/hea0000514
   Wolniczak I, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0186379
   World Bank, 2020, WWW DOC
   Yousofpour M, 2015, INT J PREVENTIVE MED, V6, DOI 10.4103/2008-7802.158178
   Zunszain Patricia A, 2013, Curr Top Behav Neurosci, V14, P135, DOI 10.1007/7854_2012_211
NR 62
TC 7
Z9 7
U1 0
U2 9
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
EI 2405-8440
J9 HELIYON
JI Heliyon
PD JUN
PY 2020
VL 6
IS 6
AR e04323
DI 10.1016/j.heliyon.2020.e04323
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA MG1KU
UT WOS:000545792600037
PM 32637706
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Miller, LJ
   Ghadiali, NY
   Larusso, EM
   Wahlen, KJ
   Avni-Barron, O
   Mittal, L
   Greene, JA
AF Miller, Laura J.
   Ghadiali, Nafisa Y.
   Larusso, Elizabeth M.
   Wahlen, Kelly J.
   Avni-Barron, Orit
   Mittal, Leena
   Greene, Judy A.
TI Bipolar Disorder in Women
SO HEALTH CARE FOR WOMEN INTERNATIONAL
LA English
DT Article
ID MENSTRUAL-CYCLE PHASE; NATIONAL EPIDEMIOLOGIC SURVEY; MAJOR DEPRESSIVE
   DISORDER; GENDER-DIFFERENCES; SEX-DIFFERENCES; POSTPARTUM PSYCHOSIS;
   LITHIUM MAINTENANCE; UNIPOLAR DEPRESSION; INCREASED FREQUENCY;
   COMORBIDITY SURVEY
AB This article summarizes research pertinent to the clinical care of women with bipolar disorder. With bipolar disorder, female gender correlates with more depressive symptoms and different comorbidities. There is a high risk of symptom recurrence postpartum and possibly during perimenopause. Women with bipolar disorder have increased risk of sexually transmitted diseases, unplanned pregnancies, excessive weight gain, metabolic syndrome, and cardiovascular disease. Mood stabilizing medications, specific psychotherapies, and lifestyle changes can stabilize mood and improve functioning. Pharmacologic considerations include understanding interactions between mood stabilizing medications and contraceptive agents and risks and benefits of mood stabilizing medication during pregnancy and lactation.
C1 [Miller, Laura J.; Ghadiali, Nafisa Y.] Edward Hines Jr VA Hosp, Loyola Stritch Sch Med, Dept Psychiat, Hines, IL 60141 USA.
   [Larusso, Elizabeth M.] Abbott NW Hosp, Allina Mental Hlth, Minneapolis, MN 55407 USA.
   [Wahlen, Kelly J.] Milwaukee Cty Behav Hlth Div, Milwaukee, WI USA.
   [Avni-Barron, Orit; Mittal, Leena] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA.
   [Mittal, Leena] Brigham & Womens Hosp, Dept Psychiat, Brookline, MA USA.
   [Greene, Judy A.] Bellevue Hosp Ctr, Div Psychiat, Womens Mental Hlth, New York, NY 10016 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Edward Hines Jr. VA Hospital; Loyola University Chicago; Harvard
   University; Harvard Medical School; Harvard University; Harvard
   University Medical Affiliates; Brigham & Women's Hospital; Bellevue
   Hospital Center
RP Miller, LJ (corresponding author), Edward Hines Jr VA Hosp, Loyola Stritch Sch Med, Dept Psychiat, 5000 S 5th Ave,Bldg 228,Room 1016, Hines, IL 60141 USA.
EM Laura.Miller8@va.gov
CR Altshuler LL, 2010, AM J PSYCHIAT, V167, P708, DOI 10.1176/appi.ajp.2009.09010105
   [Anonymous], LACTM
   Azorin JM, 2012, J AFFECT DISORDERS, V136, P710, DOI 10.1016/j.jad.2011.10.003
   Baldassano CF, 2005, BIPOLAR DISORD, V7, P465, DOI 10.1111/j.1399-5618.2005.00237.x
   Barry D, 2008, ANN EPIDEMIOL, V18, P458, DOI 10.1016/j.annepidem.2007.12.009
   Benazzi F, 2003, PSYCHOPATHOLOGY, V36, P213, DOI 10.1159/000072792
   Berenson AB, 2011, OBSTET GYNECOL, V118, P1331, DOI 10.1097/AOG.0b013e318233beae
   Bergink V, 2012, AM J PSYCHIAT, V169, P609, DOI 10.1176/appi.ajp.2012.11071047
   Bhattacharya A, 2011, COMPR PSYCHIAT, V52, P288, DOI 10.1016/j.comppsych.2010.06.010
   Blehar MC, 1998, PSYCHOPHARMACOL BULL, V34, P239
   Brockington IF, 2011, CURR PSYCHIAT REP, V13, P193, DOI 10.1007/s11920-011-0191-5
   Cairney J, 2002, SOC PSYCH PSYCH EPID, V37, P401, DOI 10.1007/s00127-002-0569-0
   Carter MJ, 2014, THER RECREAT J, V48, P275
   CHAMBERLAIN S, 1990, AM J PSYCHIAT, V147, P907
   Chou KL, 2013, DEPRESS ANXIETY, V30, P528, DOI 10.1002/da.22073
   Copeland John R M, 2004, World Psychiatry, V3, P45
   Coville AL, 2008, J CLIN PSYCHOL, V64, P438, DOI 10.1002/jclp.20463
   Cummings C, 2011, ARCH DIS CHILD, V96, P643, DOI 10.1136/adc.2009.176990
   Cunnington MC, 2011, NEUROLOGY, V76, P1817, DOI 10.1212/WNL.0b013e31821ccd18
   Magalhaes PVD, 2009, ARCH WOMEN MENT HLTH, V12, P183, DOI 10.1007/s00737-009-0060-y
   Di Florio A, 2013, JAMA PSYCHIAT, V70, P168, DOI 10.1001/jamapsychiatry.2013.279
   Dolk H, 2008, NEUROLOGY, V71, P714, DOI 10.1212/01.wnl.0000316194.98475.d8
   Frank Ellen, 2007, Dialogues Clin Neurosci, V9, P325
   Freeman MP, 2002, J CLIN PSYCHIAT, V63, P284, DOI 10.4088/JCP.v63n0403
   GLOVER V, 1994, BRIT J PSYCHIAT, V164, P517, DOI 10.1192/bjp.164.4.517
   Goldstein BI, 2011, BIPOLAR DISORD, V13, P387, DOI 10.1111/j.1399-5618.2011.00932.x
   Goldstein BI, 2009, BIPOLAR DISORD, V11, P657, DOI 10.1111/j.1399-5618.2009.00735.x
   Goldstein JM, 2014, FRONT NEUROENDOCRIN, V35, P140, DOI 10.1016/j.yfrne.2013.12.001
   Gomes FA, 2013, REV BRAS PSIQUIATR, V35, P126
   Goodwin GM, 2004, J CLIN PSYCHIAT, V65, P432
   Grant BF, 2005, J CLIN PSYCHIAT, V66, P1205, DOI 10.4088/JCP.v66n1001
   Grof P, 2000, J AFFECT DISORDERS, V61, P31, DOI 10.1016/S0165-0327(99)00197-4
   Hankin BL, 2002, J CLIN CHILD ADOLESC, V31, P491, DOI 10.1207/153744202320802160
   Hendrick V, 2000, J CLIN PSYCHIAT, V61, P393, DOI 10.4088/JCP.v61n0514
   Herzog AG, 2009, NEUROLOGY, V72, P911, DOI 10.1212/01.wnl.0000344167.78102.f0
   Holmes LB, 2008, NEUROLOGY, V70, P2152, DOI 10.1212/01.wnl.0000304343.45104.d6
   Hu XD, 2011, J COMB OPTIM, V21, P1, DOI 10.1007/s10878-010-9361-3
   Jang Y, 2011, SOC WORK PUBLIC HLTH, V26, P96, DOI 10.1080/10911350902987003
   Jiang BW, 2009, MED HYPOTHESES, V73, P996, DOI 10.1016/j.mehy.2008.12.056
   Joffe H, 2006, BIOL PSYCHIAT, V59, P1078, DOI 10.1016/j.biopsych.2005.10.017
   Joffe H, 2006, J CLIN PSYCHIAT, V67, P297, DOI 10.4088/JCP.v67n0218
   Jones I, 2001, AM J PSYCHIAT, V158, P913, DOI 10.1176/appi.ajp.158.6.913
   Karadag F, 2004, BIPOLAR DISORD, V6, P253, DOI 10.1111/j.1399-5618.2004.00112.x
   Kawa I, 2005, BIPOLAR DISORD, V7, P119, DOI 10.1111/j.1399-5618.2004.00180.x
   Kemp DE, 2010, BIPOLAR DISORD, V12, P404, DOI 10.1111/j.1399-5618.2010.00823.x
   Kendler KS, 2014, AM J PSYCHIAT, V171, P426, DOI 10.1176/appi.ajp.2013.13101375
   Kendler KS, 2005, AM J PSYCHIAT, V162, P250, DOI 10.1176/appi.ajp.162.2.250
   Kendler KS, 2001, AM J PSYCHIAT, V158, P587, DOI 10.1176/appi.ajp.158.4.587
   Kessing LV, 2008, ACTA PSYCHIAT SCAND, V117, P216, DOI 10.1111/j.1600-0447.2007.01131.x
   KESSLER RC, 1993, J AFFECT DISORDERS, V29, P85, DOI 10.1016/0165-0327(93)90026-G
   Kilbourne AM, 2007, BIPOLAR DISORD, V9, P443, DOI 10.1111/j.1399-5618.2007.00386.x
   Kriegshauser K, 2010, J NERV MENT DIS, V198, P370, DOI 10.1097/NMD.0b013e3181da8ef7
   Kuehner C, 2003, ACTA PSYCHIAT SCAND, V108, P163, DOI 10.1034/j.1600-0447.2003.00204.x
   Lane A, 1997, BRIT J PSYCHIAT, V171, P550, DOI 10.1192/bjp.171.6.550
   Larson MK, 2008, THROMB HAEMOSTASIS, V100, P634, DOI 10.1160/TH08-02-0084
   Leach LS, 2008, SOC PSYCH PSYCH EPID, V43, P983, DOI 10.1007/s00127-008-0388-z
   Lee HC, 2010, J AFFECT DISORDERS, V121, P100, DOI 10.1016/j.jad.2009.05.019
   Leibenluft E, 1999, BIOL PSYCHIAT, V46, P577, DOI 10.1016/S0006-3223(99)00023-2
   Makrides M, 2010, JAMA-J AM MED ASSOC, V304, P1675, DOI 10.1001/jama.2010.1507
   Marsh WK, 2008, J PSYCHIATR RES, V42, P247, DOI 10.1016/j.jpsychires.2006.12.006
   Marsh WK, 2009, J PSYCHIATR RES, V43, P798, DOI 10.1016/j.jpsychires.2008.11.003
   Martins JG, 2009, J AM COLL NUTR, V28, P525, DOI 10.1080/07315724.2009.10719785
   McClaskey EM, 2007, PHARMACOTHERAPY, V27, P152, DOI 10.1592/phco.27.1.152
   McElroy SL, 2011, J AFFECT DISORDERS, V128, P191, DOI 10.1016/j.jad.2010.06.037
   McKenna K, 2005, J CLIN PSYCHIAT, V66, P444, DOI 10.4088/JCP.v66n0406
   Meaney AM, 2004, BRIT J PSYCHIAT, V184, P503, DOI 10.1192/bjp.184.6.503
   Merikangas KR, 2007, ARCH GEN PSYCHIAT, V64, P543, DOI 10.1001/archpsyc.64.5.543
   Merikangas KR, 2011, ARCH GEN PSYCHIAT, V68, P241, DOI 10.1001/archgenpsychiatry.2011.12
   Miklowitz DJ, 2007, AM J PSYCHIAT, V164, P1340, DOI 10.1176/appi.ajp.2007.07020311
   MILLER LJ, 1994, HOSP COMMUNITY PSYCH, V45, P444
   Molgaard-Nielsen D, 2011, JAMA-J AM MED ASSOC, V305, P1996, DOI 10.1001/jama.2011.624
   Morris CD, 2007, J CLIN PSYCHOL, V63, P433, DOI 10.1002/jclp.20359
   Munk-Olsen T, 2012, ARCH GEN PSYCHIAT, V69, P428, DOI 10.1001/archgenpsychiatry.2011.157
   Newport DJ, 2007, AM J PSYCHIAT, V164, P1214, DOI 10.1176/appi.ajp.2007.06111886
   Nivoli AMA, 2011, J AFFECT DISORDERS, V133, P443, DOI 10.1016/j.jad.2011.04.055
   Özcan NK, 2014, J CLIN NURS, V23, P1283, DOI 10.1111/jocn.12332
   Rasgon N, 2003, BIPOLAR DISORD, V5, P48, DOI 10.1034/j.1399-5618.2003.00010.x
   Rasgon NL, 2005, J AFFECT DISORDERS, V89, P217, DOI 10.1016/j.jad.2005.08.002
   Rybakowski JK, 2006, BIOL PSYCHIAT, V60, P889, DOI 10.1016/j.biopsych.2006.03.025
   Sabers A, 2012, ACTA NEUROL SCAND, V126, pe1, DOI 10.1111/j.1600-0404.2011.01627.x
   Sarris J, 2012, J CLIN PSYCHIAT, V73, P81, DOI 10.4088/JCP.10r06710
   Schmidt P J, 2004, Arch Womens Ment Health, V7, P19, DOI 10.1007/s00737-003-0036-2
   Shariatpanaahi MV, 2007, EUR J CLIN NUTR, V61, P532, DOI 10.1038/sj.ejcn.1602542
   Sharma V, 1995, Ann Clin Psychiatry, V7, P39, DOI 10.3109/10401239509149023
   Sharma V, 2008, BIPOLAR DISORD, V10, P742, DOI 10.1111/j.1399-5618.2008.00606.x
   Shivakumar G, 2008, J WOMENS HEALTH, V17, P473, DOI 10.1089/jwh.2007.0466
   Sidhu J, 2006, BRIT J CLIN PHARMACO, V61, P191, DOI 10.1111/j.1365-2125.2005.02539.x
   Sit D, 2007, BIPOLAR DISORD, V9, P918, DOI 10.1111/j.1399-5618.2007.00451.x
   Sit D, 2011, BIPOLAR DISORD, V13, P310, DOI 10.1111/j.1399-5618.2011.00921.x
   Smith DJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0075362
   Smith S, 2002, J CLIN PSYCHOPHARM, V22, P109, DOI 10.1097/00004714-200204000-00002
   Smith S, 2009, ARCH WOMEN MENT HLTH, V12, P323, DOI 10.1007/s00737-009-0076-3
   Sonnenberg CM, 2000, ACTA PSYCHIAT SCAND, V101, P286, DOI 10.1034/j.1600-0447.2000.101004286.x
   Soreca I, 2009, DEPRESS ANXIETY, V26, P73, DOI 10.1002/da.20521
   Spinelli MG, 2009, AM J PSYCHIAT, V166, P405, DOI 10.1176/appi.ajp.2008.08121899
   Su KP, 2008, J CLIN PSYCHIAT, V69, P644, DOI 10.4088/JCP.v69n0418
   Suominen K, 2009, ACTA PSYCHIAT SCAND, V120, P464, DOI 10.1111/j.1600-0447.2009.01407.x
   Suppes T, 2005, ARCH GEN PSYCHIAT, V62, P1089, DOI 10.1001/archpsyc.62.10.1089
   Swartz HA, 2009, BIPOLAR DISORD, V11, P89, DOI 10.1111/j.1399-5618.2008.00629.x
   Tomson T, 2009, NEUROL CLIN, V27, P993, DOI 10.1016/j.ncl.2009.06.006
   Uddin M, 2013, DEPRESS ANXIETY, V30, P1151, DOI 10.1002/da.22167
   Undurraga J, 2012, J CLIN PSYCHIAT, V73, P778, DOI 10.4088/JCP.11m07041
   Viguera AC, 2000, AM J PSYCHIAT, V157, P179, DOI 10.1176/appi.ajp.157.2.179
   Viguera AC, 2001, BIPOLAR DISORD, V3, P245, DOI 10.1034/j.1399-5618.2001.30503.x
   Viguera AC, 2007, AM J PSYCHIAT, V164, P1817, DOI 10.1176/appi.ajp.2007.06101639
   Viguera AC, 2011, AM J PSYCHIAT, V168, P1179, DOI 10.1176/appi.ajp.2011.11010148
   Weinstock LM, 2010, COMPR PSYCHIAT, V51, P497, DOI 10.1016/j.comppsych.2010.02.001
   Westman J, 2013, BMJ OPEN, V3
   WISNER KL, 1994, J AFFECT DISORDERS, V30, P77, DOI 10.1016/0165-0327(94)90034-5
   Yonkers KA, 2004, AM J PSYCHIAT, V161, P608, DOI 10.1176/appi.ajp.161.4.608
   Young RC, 1997, AM J GERIAT PSYCHIAT, V5, P179
   Young RC, 2007, BIPOLAR DISORD, V9, P301, DOI 10.1111/j.1399-5618.2007.00393.x
NR 112
TC 20
Z9 21
U1 1
U2 22
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0739-9332
EI 1096-4665
J9 HEALTH CARE WOMEN IN
JI Health Care Women Int.
PD APR 3
PY 2015
VL 36
IS 4
BP 475
EP 498
DI 10.1080/07399332.2014.962138
PG 24
WC Public, Environmental & Occupational Health; Women's Studies
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Women's Studies
GA CF1QO
UT WOS:000352322900009
PM 25315819
DA 2025-06-11
ER

PT J
AU Shahanoor, Z
   Sultana, R
   Baker, MR
   Romeo, RD
AF Shahanoor, Ziasmin
   Sultana, Razia
   Baker, Madelyn R.
   Romeo, Russell D.
TI Neuroendocrine stress reactivity of male C57BL/6N mice following chronic
   oral corticosterone exposure during adulthood or adolescence
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Adolescence; Oral-corticosterone; Paraventricular nucleus; Plasma
   corticosterone
ID METABOLIC SYNDROME; STEROID-HORMONES; FEMALE RATS; PUBERTY; BRAIN;
   RESPONSES; AXIS
AB Adolescence is associated with the maturation of the hypothalamic-pituitary-adrenal (HPA) axis, the major neuroendocrine axis mediating the hormonal stress response. Adolescence is also a period in development marked by a variety of stress-related vulnerabilities, including psychological and physiological dysfunctions. Many of these vulnerabilities are accompanied by a disrupted HPA axis. In adult mice, a model of disrupted HPA function has been developed using oral chronic corticosterone administration via the drinking water, which results in various physiological and neurobehavioral abnormalities, including changes in stress reactivity and anxiety-like behaviors. In an effort to further complement and extend this model, we tested the impact of HPA disruption in adolescent mice. We also examined whether this disruption led to different outcomes depending on whether the treatment happened during adolescence or adulthood. In the current set of experiments, we exposed adult (70 days of age) or adolescent (30 days of age) male C57BL/6N mice to 4 weeks of either 0 or 25 mu g/m1 oral corticosterone via their drinking water. We measured body weight during treatment and plasma corticosterone levels and activation of the paraventricular nucleus (PVN), as indexed by FOS immunohistochemistry, before and after a 30 min session of restraint stress. Our data indicate that adolescent animals exposed to chronic corticosterone showed weight loss during treatment, an effect not observed in adults. Further, we found stress failed to elevate plasma corticosterone levels in treated mice, regardless of whether exposure occurred in adulthood or adolescence. Despite this reduced hormonal responsiveness, we found significant neural activation in the PVN of both adult- and adolescent-treated mice, indicating a dissociation between stress-induced peripheral and central stress responses following chronic corticosterone exposure. Moreover, stress-induced neural activation in the PVN was unaffected by chronic corticosterone treatment in adult animals, but led to a hyper responsive PVN in the corticosterone-treated adolescent animals, suggesting an age-specific effect of corticosterone treatment on later PVN stress reactivity. Together, these experiments highlight the influence of developmental stage on somatic and neuroendocrine outcomes following chronic HPA disruption by noninvasive, oral corticosterone treatment. Given the substantial vulnerabilities to HPA dysfunctions during adolescence this model may prove useful in better understanding these vulnerabilities.
C1 [Romeo, Russell D.] Columbia Univ, Dept Psychol, Barnard Coll, New York, NY 10027 USA.
   Columbia Univ, Barnard Coll, Neurosci & Behav Program, New York, NY 10027 USA.
C3 Columbia University; Barnard College; Columbia University; Barnard
   College
RP Romeo, RD (corresponding author), Columbia Univ, Dept Psychol, Barnard Coll, New York, NY 10027 USA.
EM rromeo@barnard.edu
OI Baker, Madelyn/0000-0002-4231-1857
FU Faculty Research Grant from Barnard College
FX We would like to thank Page Buchanan for excellent animal care. This
   work was supported in part by a Faculty Research Grant from Barnard
   College.
CR Cassano AE, 2012, COMPARATIVE MED, V62, P1
   Chanson P, 2010, NEUROENDOCRINOLOGY, V92, P96, DOI 10.1159/000314272
   de Kloet ER, 2005, NAT REV NEUROSCI, V6, P463, DOI 10.1038/nrn1683
   Doremus-Fitzwater TL, 2009, PHYSIOL BEHAV, V97, P484, DOI 10.1016/j.physbeh.2009.03.025
   Foilb AR, 2011, J ENDOCRINOL, V210, P391, DOI 10.1530/JOE-11-0206
   Karatsoreos IN, 2010, ENDOCRINOLOGY, V151, P2117, DOI 10.1210/en.2009-1436
   Kinlein SA, 2017, ENDOCRINOLOGY, V158, P2239, DOI 10.1210/en.2017-00208
   Kinlein SA, 2015, FRONT PSYCHIATRY, V6, DOI 10.3389/fpsyt.2015.00031
   Koplowitz E. T., 2011, J NEUROENDOCRINOL, V28, P1
   Lee FS, 2014, SCIENCE, V346, P547, DOI 10.1126/science.1260497
   Lui P, 2012, PHYSIOL BEHAV, V107, P104, DOI 10.1016/j.physbeh.2012.06.011
   McCormick CM, 2013, NEUROSCIENCE, V249, P242, DOI 10.1016/j.neuroscience.2012.08.063
   McCormick CM, 2007, PHARMACOL BIOCHEM BE, V86, P220, DOI 10.1016/j.pbb.2006.07.012
   McCormick CM, 2010, PROG NEURO-PSYCHOPH, V34, P756, DOI 10.1016/j.pnpbp.2009.09.019
   McCormick CM, 2010, BRAIN COGNITION, V72, P73, DOI 10.1016/j.bandc.2009.06.003
   Pariante CM, 2008, TRENDS NEUROSCI, V31, P464, DOI 10.1016/j.tins.2008.06.006
   Romeo RD, 2006, ENDOCRINOLOGY, V147, P1664, DOI 10.1210/en.2005-1432
   Romeo RD, 2004, NEUROENDOCRINOLOGY, V80, P387, DOI 10.1159/000084203
   Romeo RD, 2004, NEUROENDOCRINOLOGY, V79, P125, DOI 10.1159/000077270
   Romeo RD, 2003, J NEUROENDOCRINOL, V15, P1185, DOI 10.1111/j.1365-2826.2003.01106.x
   Romeo RD, 2017, BRAIN RES, V1654, P185, DOI 10.1016/j.brainres.2016.03.021
   Romeo RD, 2016, NEUROSCI BIOBEHAV R, V70, P206, DOI 10.1016/j.neubiorev.2016.05.020
   Romeo RD, 2013, PSYCHONEUROENDOCRINO, V38, P592, DOI 10.1016/j.psyneuen.2012.07.019
   Romeo RD, 2010, FRONT NEUROENDOCRIN, V31, P232, DOI 10.1016/j.yfrne.2010.02.004
   Romeo RD, 2010, DEV PSYCHOBIOL, V52, P244, DOI 10.1002/dev.20437
   Schulz KM, 2016, NEUROSCI BIOBEHAV R, V70, P148, DOI 10.1016/j.neubiorev.2016.07.036
   Sisk CL, 2004, NAT NEUROSCI, V7, P1040, DOI 10.1038/nn1326
   Spear LP, 2000, NEUROSCI BIOBEHAV R, V24, P417, DOI 10.1016/S0149-7634(00)00014-2
   Ulrich-Lai YM, 2009, NAT REV NEUROSCI, V10, P397, DOI 10.1038/nrn2647
   Waters P, 2011, BIOL MOOD ANXIETY DI, V1, DOI 10.1186/2045-5380-1-4
   Xu ZW, 2011, J AFFECT DISORDERS, V131, P128, DOI 10.1016/j.jad.2010.11.005
NR 31
TC 18
Z9 22
U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD DEC
PY 2017
VL 86
BP 218
EP 224
DI 10.1016/j.psyneuen.2017.10.001
PG 7
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA FN1WG
UT WOS:000415781300026
PM 29020649
DA 2025-06-11
ER

PT J
AU Bernert, RA
   Luckenbaugh, DA
   Duncan, WC
   Iwata, NG
   Ballard, ED
   Zarate, CA
AF Bernert, Rebecca A.
   Luckenbaugh, David A.
   Duncan, Wallace C.
   Iwata, Naomi G.
   Ballard, Elizabeth D.
   Zarate, Carlos A.
TI Sleep architecture parameters as a putative biomarker of suicidal
   ideation in treatment-resistant depression
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Sleep architecture; Suicide risk; Depression; Bipolar disorder;
   Treatment-resistance
ID COGNITIVE-BEHAVIORAL THERAPY; BIPOLAR DISORDER; METABOLIC SYNDROME;
   MENTAL-DISORDERS; INSOMNIA; RISK; DISTURBANCE; HOPELESSNESS; SYMPTOMS;
   KETAMINE
AB Background: Disturbed sleep may confer risk for suicidal behaviors. Polysomnographic (PSG) sleep parameters have not been systematically evaluated in association with suicidal ideation (SI) among individuals with treatment-resistant depression (TRD).
   Methods: This secondary data analysis included 54 TRD individuals (N=30 with major depressive disorder (MDD) and N=24 with bipolar depression (BD)). PSG sleep parameters included Sleep Efficiency (SE), Total Sleep Time (TST), Wakefulness After Sleep Onset (WASO), REM percent/latency, and non-REM (NREM) Sleep Stages 1-4. The Hamilton Depression Rating Scale (HAM-D) was used to group participants according to presence or absence of SI. Sleep abnormalities were hypothesized among those with current SI. ANOVA analyses were conducted before (Model 1) and after adjusting for depression (Model 2) and diagnostic variables (Model 3).
   Results: Significant differences in PSG parameters were observed in Model 1; those with SI had less NREM Stage 4 sleep (p <.05). After adjusting for central covariates, Models 2 and 3 revealed significantly less NREM Stage 4 sleep, lower SE (P <.05), and higher WASO (P <.05) among those with SI. BD participants with SI also had less NREM Stage 4 and more NREM Stage 1 sleep.
   Limitations: 1) a predominantly white sample; 2) exclusion of imminent suicide risk; 3) concomitant mood stabilizer use among BD patients; and 4) single-item SI assessment.
   Conclusions: Independent of depression severity, SI was associated with less NREM Stage 4 sleep, and higher nocturnal wakefulness across diagnostic groups. Sleep may warrant further investigation in the pathogenesis of suicide risk, particularly in TRD, where risk may be heightened.
C1 [Bernert, Rebecca A.; Iwata, Naomi G.] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Suicide Prevent Res Lab, Stanford, CA 94305 USA.
   [Luckenbaugh, David A.; Duncan, Wallace C.; Ballard, Elizabeth D.; Zarate, Carlos A.] NIMH, Expt Therapeut & Pathophysiol Branch, Intramural Res Program, NIH, Bethesda, MD 20892 USA.
C3 Stanford University; National Institutes of Health (NIH) - USA; NIH
   National Institute of Mental Health (NIMH)
RP Bernert, RA (corresponding author), Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Suicide Prevent Res Lab, Stanford, CA 94305 USA.
EM rbernert@stanford.edu
RI Zarate, Carlos/ABD-6843-2021; Ballard, Elizabeth/O-6856-2017
OI Ballard, Elizabeth/0000-0001-5304-0127
CR Agargun MY, 2003, PSYCHIAT RES, V119, P33, DOI 10.1016/S0165-1781(03)00111-2
   Ahmadpanah M, 2015, INT J PSYCHIAT CLIN, V19, P168, DOI 10.3109/13651501.2015.1049277
   Alexopoulos GS, 1999, ARCH GEN PSYCHIAT, V56, P1048, DOI 10.1001/archpsyc.56.11.1048
   [Anonymous], PSYCHIAT RES
   [Anonymous], 2002, Reducing suicide: A national imperative
   [Anonymous], BR J PSYCHIAT
   [Anonymous], 2021, TREATMENT IMPROVEMEN
   [Anonymous], PUBL REP SURG GEN 20
   [Anonymous], AM J PSYCHIAT
   [Anonymous], TRENDS SUIC RAT PERS
   [Anonymous], 2013, MENT HLTH ACT PLAN 2
   Bernert RA, 2005, SLEEP, V28, P1135, DOI 10.1093/sleep/28.9.1135
   Bernert Rebecca A, 2007, Neuropsychiatr Dis Treat, V3, P735
   Bernert RA, 2015, CURR PSYCHIAT REP, V17, DOI 10.1007/s11920-015-0554-4
   Bernert RA, 2014, JAMA PSYCHIAT, V71, P1129, DOI 10.1001/jamapsychiatry.2014.1126
   Bertolote Jose Manoel, 2004, Crisis, V25, P147, DOI 10.1027/0227-5910.25.4.147
   Bianchi MT, 2013, J SLEEP RES, V22, P557, DOI 10.1111/jsr.12046
   Carli V, 2014, WORLD PSYCHIATRY, V13, P78, DOI 10.1002/wps.20088
   Carney CE, 2011, DEPRESS ANXIETY, V28, P464, DOI 10.1002/da.20811
   Cavanagh JTO, 2003, PSYCHOL MED, V33, P395, DOI 10.1017/S0033291702006943
   Chesney E, 2014, WORLD PSYCHIATRY, V13, P153, DOI 10.1002/wps.20128
   Claassen CA, 2007, J AFFECT DISORDERS, V97, P77, DOI 10.1016/j.jad.2006.05.026
   Desseilles M, 2012, J AFFECT DISORDERS, V136, P398, DOI 10.1016/j.jad.2011.11.013
   Dorsey CM, 1997, BIOL PSYCHIAT, V41, P209, DOI 10.1016/0006-3223(95)00659-1
   Duncan WC, 2013, INT J NEUROPSYCHOPH, V16, P301, DOI 10.1017/S1461145712000545
   Duncan WC, 2013, J AFFECT DISORDERS, V145, P115, DOI 10.1016/j.jad.2012.05.042
   Dunner DL, 2006, J CLIN PSYCHIAT, V67, P688, DOI 10.4088/JCP.v67n0501
   Fava M, 2003, BIOL PSYCHIAT, V53, P649, DOI 10.1016/S0006-3223(03)00231-2
   First MB., 2002, STRUCTURED CLIN INTE
   Frank E, 2000, BIOL PSYCHIAT, V48, P593, DOI 10.1016/S0006-3223(00)00969-0
   FRANKEL BL, 1976, ARCH GEN PSYCHIAT, V33, P615
   FRISTON KJ, 1989, PSYCHOPHARMACOLOGY, V98, P139, DOI 10.1007/BF00442020
   Goldstein TR, 2008, J CONSULT CLIN PSYCH, V76, P84, DOI 10.1037/0022-006X.76.1.84
   Griffiths JJ, 2014, AM J PREV MED, V47, pS195, DOI 10.1016/j.amepre.2014.06.012
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   HARDING GFA, 1985, EPILEPSIA, V26, P597, DOI 10.1111/j.1528-1157.1985.tb05698.x
   Harris EC, 1997, BRIT J PSYCHIAT, V170, P205, DOI 10.1192/bjp.170.3.205
   Harvey AG, 2008, AM J PSYCHIAT, V165, P820, DOI 10.1176/appi.ajp.2008.08010098
   Ibrahim L, 2012, NEUROPSYCHOPHARMACOL, V37, P1526, DOI 10.1038/npp.2011.338
   Karp JF, 2004, AM J PSYCHIAT, V161, P1877, DOI 10.1176/appi.ajp.161.10.1877
   KESHAVAN MS, 1994, ACTA PSYCHIAT SCAND, V89, P122, DOI 10.1111/j.1600-0447.1994.tb01498.x
   Kramer I, 2014, WORLD PSYCHIATRY, V13, P68, DOI 10.1002/wps.20090
   KUPFER DJ, 1974, ARCH GEN PSYCHIAT, V30, P79
   Kupfer DJ, 2005, JAMA-J AM MED ASSOC, V293, P2528, DOI 10.1001/jama.293.20.2528
   Lewinsohn PM, 1996, CLIN PSYCHOL-SCI PR, V3, P25, DOI 10.1111/j.1468-2850.1996.tb00056.x
   May AM, 2012, J PSYCHIATR RES, V46, P946, DOI 10.1016/j.jpsychires.2012.04.009
   McCall WV, 2010, SLEEP MED, V11, P822, DOI 10.1016/j.sleep.2010.04.004
   Morin CM, 2009, JAMA-J AM MED ASSOC, V301, P2005, DOI 10.1001/jama.2009.682
   Nadorff MR, 2011, SLEEP, V34, P93, DOI 10.1093/sleep/34.1.93
   Ng TH, 2015, SLEEP MED REV, V20, P46, DOI 10.1016/j.smrv.2014.06.006
   Ohayon MM, 2004, SLEEP, V27, P1255, DOI 10.1093/sleep/27.7.1255
   Papakostas GI, 2003, J NERV MENT DIS, V191, P444, DOI 10.1097/01.NMD.0000081591.46444.97
   Pigeon WR, 2012, SLEEP, V35, pA326
   Pompili M, 2013, INT J CLIN PRACT, V67, P1311, DOI 10.1111/ijcp.12211
   Pompili M, 2013, J AFFECT DISORDERS, V150, P216, DOI 10.1016/j.jad.2013.03.026
   Raison CL, 2013, JAMA PSYCHIAT, V70, P31, DOI 10.1001/2013.jamapsychiatry.4
   Rechtschaffen A., 1968, MANUAL STANDARDIZED
   Ribeiro JD, 2012, J AFFECT DISORDERS, V136, P743, DOI 10.1016/j.jad.2011.09.049
   SABO E, 1991, PSYCHIAT RES, V36, P265, DOI 10.1016/0165-1781(91)90025-K
   Sackeim HA, 2001, J CLIN PSYCHIAT, V62, pS10
   Saxena S., 2014, PREVENTING SUICIDE G
   Shakeri J, 2015, INT J PSYCHIAT CLIN, V19, P124, DOI 10.3109/13651501.2014.988271
   Sjöström N, 2009, PSYCHIAT RES, V170, P208, DOI 10.1016/j.psychres.2008.09.006
   Smith MT, 2004, CLIN J PAIN, V20, P111, DOI 10.1097/00002508-200403000-00008
   Tondo L, 2003, CNS DRUGS, V17, P491, DOI 10.2165/00023210-200317070-00003
   Trajkovic G, 2011, PSYCHIAT RES, V189, P1, DOI 10.1016/j.psychres.2010.12.007
   Troxel WM, 2012, J CLIN PSYCHIAT, V73, P478, DOI 10.4088/JCP.11m07184
   Vanable PA, 2000, SLEEP, V23, P71
   Wong MM, 2012, J PSYCHIATR RES, V46, P953, DOI 10.1016/j.jpsychires.2012.04.008
   Zarate CA Jr, 2012, BIOL PSYCHIAT, V71, P939, DOI 10.1016/j.biopsych.2011.12.010
   Zisook S, 2009, J AFFECT DISORDERS, V117, P63, DOI 10.1016/j.jad.2009.01.002
   Zucconi M, 1996, J CLIN PSYCHIAT, V57, P364
NR 72
TC 56
Z9 59
U1 0
U2 26
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JAN 15
PY 2017
VL 208
BP 309
EP 315
DI 10.1016/j.jad.2016.08.050
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA EG0OR
UT WOS:000390732600045
PM 27810712
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Glass, DC
   Contrada, RJ
AF Glass, David C.
   Contrada, Richard J.
TI Bipolar disorder, Type A behaviour and coronary disease
SO HEALTH PSYCHOLOGY REVIEW
LA English
DT Article
DE bipolar disorder; Type A behaviour; depression; coronary heart disease
ID CARDIOVASCULAR RISK-FACTORS; HEART-DISEASE; LIFE EVENTS; METABOLIC
   SYNDROME; ARTERY-DISEASE; I-DISORDER; FOLLOW-UP; EPIDEMIOLOGIC EVIDENCE;
   DEPRESSIVE SYMPTOMS; GENERAL-POPULATION
AB This paper presents a model for integrating two psychological constructs - bipolar disorder and the Type A behaviour pattern - each of which has been associated with enhanced risk of coronary heart disease (CHD). It describes similarities between manic/hypomanic behaviours associated with bipolarity and the behaviours observed in Type A individuals. The proposed model highlights the importance of alternating patterns of coping with challenging and stressful life events. Thus, initial coping efforts are manifested as behavioural hyper-reactivity (i.e., Type A behaviours and mania/hypomania), but this gives way to hypo-reactivity (including helplessness and depression) after repeated failure to assert control and/or attain relevant goals. This alternation of what originally were regarded as Type A coping patterns resembles the affective and behavioural transitions often seen in bipolar patients. Future research on psychological, epidemiological and pathophysiological issues concerning CHD should document areas of commonality and independence between bipolarity and Type A behaviour. Such studies would benefit from consideration of a model that identifies psychosocial dimensions common to Type A, mania/hypomania and depression.
C1 [Contrada, Richard J.] Rutgers State Univ, Dept Psychol, Piscataway, NJ 08854 USA.
   [Glass, David C.] SUNY Stony Brook, Dept Psychol, Riverdale, NY 10463 USA.
C3 Rutgers University System; Rutgers University New Brunswick; State
   University of New York (SUNY) System; Stony Brook University
RP Contrada, RJ (corresponding author), Rutgers State Univ, Dept Psychol, 53 Ave E,Tillett Hall,Livingston Campus, Piscataway, NJ 08854 USA.
EM contrada@rci.rutgers.edu
CR Akiskal HS, 2000, J AFFECT DISORDERS, V59, pS5, DOI 10.1016/S0165-0327(00)00203-2
   Anderson B., 2011, The handbook of stress science: biology, psychology, and health, P565
   Angst F, 2002, J AFFECT DISORDERS, V68, P167, DOI 10.1016/S0165-0327(01)00377-9
   [Anonymous], 1994, J AFFECT DISORDERS
   [Anonymous], 1981, Cardiovascular psychophysiology, cardiovascular psychophysiology, DOI DOI 10.4324/9781315081762
   APA A.P. A., 2000, Diagnostic and statistical manual of mental disorders: DSM-IV, V4th
   APPELS A, 1990, BRIT J PSYCHIAT, V156, P465, DOI 10.1192/bjp.156.4.465
   BAREFOOT JC, 1990, PSYCHOL ASSESSMENT, V2, P483
   Barrick CB, 1999, J AFFECT DISORDERS, V53, P193, DOI 10.1016/S0165-0327(98)00184-0
   Baune BT, 2006, PSYCHOTHER PSYCHOSOM, V75, P319, DOI 10.1159/000093955
   Bekkouche N.S., 2011, HDB STRESS SCI BIOL, P385
   Betensky JD, 2010, ANN BEHAV MED, V39, P184, DOI 10.1007/s12160-010-9176-6
   BLACK DW, 1987, J NERV MENT DIS, V175, P674, DOI 10.1097/00005053-198711000-00005
   BOOTHKEWLEY S, 1987, PSYCHOL BULL, V101, P343, DOI 10.1037/0033-2909.101.3.343
   Boyle SH, 2007, BRAIN BEHAV IMMUN, V21, P816, DOI 10.1016/j.bbi.2007.01.008
   BRUNSON BI, 1981, J PERS SOC PSYCHOL, V40, P906, DOI 10.1037/0022-3514.40.5.906
   BYRNE DG, 1986, J PSYCHOSOM RES, V30, P663, DOI 10.1016/0022-3999(86)90100-5
   Carver CS, 2008, PSYCHOL BULL, V134, P912, DOI 10.1037/a0013740
   Chida Y, 2008, PSYCHOL BULL, V134, P829, DOI 10.1037/a0013342
   CONDUIT EH, 1992, BRIT J MED PSYCHOL, V65, P289, DOI 10.1111/j.2044-8341.1992.tb01709.x
   ENGEL GL, 1971, ANN INTERN MED, V74, P771, DOI 10.7326/0003-4819-74-5-771
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   FALGER PR, 1989, LIFE SPAN DEV MYOCAR
   Fiedorowicz JG, 2008, ANN CLIN PSYCHIATRY, V20, P131, DOI 10.1080/10401230802177722
   Fiedorowicz JG, 2009, PSYCHOSOM MED, V71, P598, DOI 10.1097/PSY.0b013e3181acee26
   Francis K.T., 1982, J PSYCHIATR RES, V16, P183
   FRANKENHAEUSER M, 1971, BRAIN RES, V31, P241, DOI 10.1016/0006-8993(71)90180-6
   Friedman M., 1984, Treating Type A behavior
   Friedman Meyer, 1974, TYPE BEHAV YOUR HEAR
   Garcia-Portilla MP, 2009, J AFFECT DISORDERS, V115, P302, DOI 10.1016/j.jad.2008.09.008
   Glass D.C., 1977, BEHAV PATTERNS STRES, DOI DOI 10.1016/j.jad.2004.01.013
   Glass DC, 1982, BASIC APPL SOC PSYCH, V3, P161, DOI 10.1207/s15324834basp0303_1
   GLASS DC, 1984, NOREPINEPHRINE FRONT, V2, P346
   Goldstein BI, 2009, BIPOLAR DISORD, V11, P657, DOI 10.1111/j.1399-5618.2009.00735.x
   Goldston K, 2008, CLIN PSYCHOL REV, V28, P288, DOI 10.1016/j.cpr.2007.05.005
   GREENE WA, 1972, ARCH INTERN MED, V129, P725, DOI 10.1001/archinte.129.5.725
   Hartmann F., 1972, ARCH GEN PSYCHIAT, V26, P463
   HICKS RA, 1979, B PSYCHONOMIC SOC, V14, P185
   Jamison KayRedfield., 2007, Manic-Depressive Illness: Bipolar Disorders and Recurrent Depression, V2nd
   Johnson M, 2002, PERS INDIV DIFFER, V33, P777, DOI 10.1016/S0191-8869(01)00191-X
   Johnson SL, 2008, J ABNORM PSYCHOL, V117, P268, DOI 10.1037/0021-843X.117.2.268
   Johnson SL, 2006, INTERPERSONAL, COGNITIVE, AND SOCIAL NATURE OF DEPRESSION, P153
   Johnson SL, 2009, BRIT J CLIN PSYCHOL, V48, P217, DOI 10.1348/014466509X414655
   Johnson SL, 2005, CLIN PSYCHOL REV, V25, P241, DOI 10.1016/j.cpr.2004.11.002
   Johnson SL, 2005, CLIN PSYCHOL REV, V25, P1008, DOI 10.1016/j.cpr.2005.06.004
   Judd LL, 2003, INT J NEUROPSYCHOPH, V6, P127, DOI 10.1017/S1461145703003341
   KAMARCK T, 1991, PSYCHOL BULL, V109, P42, DOI 10.1037/0033-2909.109.1.42
   Kamarck T.W., 2011, The handbook of stress science: Biology, psychology, and health, P597
   Kessler RC, 1997, PSYCHOL MED, V27, P1079, DOI 10.1017/S0033291797005333
   Kilbourne AM, 2007, BIPOLAR DISORD, V9, P443, DOI 10.1111/j.1399-5618.2007.00386.x
   Kilbourne AM, 2009, GEN HOSP PSYCHIAT, V31, P555, DOI 10.1016/j.genhosppsych.2009.07.008
   Kop WJ, 2003, BRAIN BEHAV IMMUN, V17, P233, DOI 10.1016/S0889-1591(03)00051-5
   Kop WJ, 1999, PSYCHOSOM MED, V61, P476, DOI 10.1097/00006842-199907000-00012
   Krantz D.S., 1984, HDB BEHAV MED, P38
   Krantz DS, 2002, ANNU REV PSYCHOL, V53, P341, DOI 10.1146/annurev.psych.53.100901.135208
   Laursen TM, 2007, J CLIN PSYCHIAT, V68, P899, DOI 10.4088/JCP.v68n0612
   Lozano BE, 2001, J AFFECT DISORDERS, V63, P103, DOI 10.1016/S0165-0327(00)00191-9
   Maeng SH, 2008, P NATL ACAD SCI USA, V105, P8766, DOI 10.1073/pnas.0803736105
   Malkoff-Schwartz S, 2000, PSYCHOL MED, V30, P1005, DOI 10.1017/S0033291799002706
   Matthews K.A., 1980, J PERS SOC PSYCHOL, V30, P962
   Matthews K.A., 1982, PSYCHOL BULL, V91, P292
   MATTHEWS KA, 1988, PSYCHOL BULL, V104, P373, DOI 10.1037/0033-2909.104.3.373
   Matthews KA, 2005, AM PSYCHOL, V60, P783, DOI 10.1037/0003-066X.60.8.783
   MCKELVIE SJ, 1992, J PSYCHOL, V126, P285, DOI 10.1080/00223980.1992.10543362
   Miller GE, 2007, PSYCHOL BULL, V133, P25, DOI 10.1037/0033-2909.133.1.25
   Miller TQ, 1996, PSYCHOL BULL, V119, P322, DOI 10.1037/0033-2909.119.2.322
   MURPHY JM, 1987, ARCH GEN PSYCHIAT, V44, P473
   Nusslock R, 2007, J ABNORM PSYCHOL, V116, P105, DOI 10.1037/0021-843X.116.1.105
   Oedegaard KJ, 2006, J AFFECT DISORDERS, V90, P7, DOI 10.1016/j.jad.2005.10.005
   Ösby U, 2001, ARCH GEN PSYCHIAT, V58, P844, DOI 10.1001/archpsyc.58.9.844
   Peterson C., 1993, Learned helplessness: A theory for the age of personal control
   POWELL LH, 1992, COGNITIVE THER RES, V16, P123, DOI 10.1007/BF01173485
   Rosenman R.H., 1978, CORONARY PRONE BEHAV, P55, DOI [DOI 10.1007/978-3-642-86007-2_4, 10.1007/978-3-642-86007-2_4]
   ROSENMAN RH, 1975, JAMA-J AM MED ASSOC, V233, P872, DOI 10.1001/jama.233.8.872
   SHARMA R, 1994, J AFFECT DISORDERS, V31, P91, DOI 10.1016/0165-0327(94)90112-0
   Stewart JC, 2010, ANN BEHAV MED, V39, P258, DOI 10.1007/s12160-010-9185-5
   Suarez EC, 2003, PSYCHOSOM MED, V65, P523, DOI 10.1097/01.PSY.0000062530.94551.EA
   SULS J, 1979, J PSYCHOSOM RES, V23, P315, DOI 10.1016/0022-3999(79)90037-0
   TSUANG MT, 1980, BRIT J PSYCHIAT, V136, P239, DOI 10.1192/bjp.136.3.239
   van Winkel R, 2008, BIPOLAR DISORD, V10, P342, DOI 10.1111/j.1399-5618.2007.00520.x
   WEEKE A, 1986, J AFFECT DISORDERS, V11, P227, DOI 10.1016/0165-0327(86)90074-1
   Weinstein AA, 2010, BIOL PSYCHOL, V84, P228, DOI 10.1016/j.biopsycho.2010.01.016
   Wortman C.B., 1975, ADV EXP SOC PSYCHOL, V8, P278, DOI 10. 1016/S0065-2601(08)60253-1
   YATES WR, 1987, J AFFECT DISORDERS, V12, P129, DOI 10.1016/0165-0327(87)90004-8
NR 84
TC 3
Z9 3
U1 0
U2 20
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1743-7199
J9 HEALTH PSYCHOL REV
JI Health Psychol. Rev.
PY 2012
VL 6
IS 2
BP 180
EP 196
DI 10.1080/17437199.2010.531568
PG 17
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA 975SA
UT WOS:000306530100004
DA 2025-06-11
ER

PT J
AU Gonçalves, RA
   Wijesekara, N
   Fraser, PE
   De Felice, FG
AF Goncalves, Rafaella Araujo
   Wijesekara, Nadeeja
   Fraser, Paul E.
   De Felice, Fernanda G.
TI Behavioral Abnormalities in Knockout and Humanized Tau Mice
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE Alzheimer's disease; MAPT; Tau protein; insulin; anxiety; metabolism;
   memory
ID MICROTUBULE-ASSOCIATED PROTEIN; MILD COGNITIVE IMPAIRMENT;
   DEPRESSIVE-LIKE BEHAVIOR; AMYLOID-BETA OLIGOMERS; INSULIN-RESISTANCE;
   ALZHEIMERS-DISEASE; METABOLIC SYNDROME; DEFICITS; RISK; SYMPTOMS
AB Microtubule-associated protein tau assists in stabilizing microtubules and has been particularly implicated in Alzheimer's disease (AD). Given the importance of tau to AD pathogenesis and therapies, it is important to understand non-classic physiological functions for this protein inside and outside the central nervous system (CNS). Our group has previously shown that tau ablation triggers glucose intolerance and pancreatic dysfunction in mice, suggesting that tau plays a role in peripheral metabolic regulation. Little is known about the role of tau in anxiety. Moreover, inconsistent results have been generated regarding the effects of tau deletion in memory. Here, we characterize systemic insulin resistance, anxiety-related behavior and memory in 15 to 20 weeks old Wild-Type (WT), Tau knockout (TauKO) and a distinct hTau mouse model consisting of tau knockout expressing the longest isoform (2N4R) of a non-mutant WT human Tau protein under the prion promoter (hTau). Our findings demonstrate that tau deletion leads to anxiety-related behavior, impaired contextual and cued fear memory. The presence of a human Tau transgene did not ameliorate the phenotypes observed in animals lacking the mouse tau protein and it elicited impairments in learning, memory, and peripheral insulin sensitivity. Our results suggest that tau protein plays a role in memory and anxiety-related behavior. Our findings also indicate that previously unrecognized functions for tau protein may be a complicating factor in using animal models on the TauKO background. Understanding the link between tau pathophysiology and cognitive and metabolic alterations is of great importance to establish the complete contribution of tau protein to AD pathogenesis.
C1 [Goncalves, Rafaella Araujo; De Felice, Fernanda G.] Queens Univ, Ctr Neurosci Studies, Kingston, ON, Canada.
   [Goncalves, Rafaella Araujo; Wijesekara, Nadeeja; Fraser, Paul E.] Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada.
   [Fraser, Paul E.] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada.
   [De Felice, Fernanda G.] Queens Univ, Dept Psychiat, Kingston, ON, Canada.
   [De Felice, Fernanda G.] Univ Fed Rio de Janeiro, Inst Med Biochem Leopoldo de Meis, Rio De Janeiro, Brazil.
C3 Queens University - Canada; University of Toronto; University of
   Toronto; Queens University - Canada; Universidade Federal do Rio de
   Janeiro
RP De Felice, FG (corresponding author), Queens Univ, Ctr Neurosci Studies, Kingston, ON, Canada.; Fraser, PE (corresponding author), Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada.; Fraser, PE (corresponding author), Univ Toronto, Dept Med Biophys, Toronto, ON, Canada.; De Felice, FG (corresponding author), Queens Univ, Dept Psychiat, Kingston, ON, Canada.; De Felice, FG (corresponding author), Univ Fed Rio de Janeiro, Inst Med Biochem Leopoldo de Meis, Rio De Janeiro, Brazil.
EM paul.fraser@utoronto.ca; felice@bioqmed.ufrj.br
RI Wijesekara, Nadeeja/AAW-7230-2021; De Felice, Fernanda/M-1074-2017
OI WIJESEKARA, NADEEJA/0000-0001-5298-9779; Araujo Goncalves,
   Rafaella/0000-0001-5334-0816
FU Canadian Institutes of Health Research (CIHR) [MOP-115056]; Alzheimer
   Society of Ontario; Alzheimer's Society Canada; Weston Brain Institute,
   National Institute for Translational Neuroscience (INNT/Brazil)
   [465346/2014-6]; Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq) [473324/2013-0]; Fundacao de Amparo a Pesquisa do
   Estado do Rio de Janeiro (FAPERJ) [202.944/2015]; Diabetes Canada
FX Work from PF laboratory was supported by grants from Canadian Institutes
   of Health Research (CIHR) (MOP-115056) and the Alzheimer Society of
   Ontario. Work from FD laboratory was supported by grants from
   Alzheimer's Society Canada and the Weston Brain Institute, National
   Institute for Translational Neuroscience (INNT/Brazil) (465346/2014-6),
   and the Brazilian funding agencies Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq) (473324/2013-0) and Fundacao de Amparo a
   Pesquisa do Estado do Rio de Janeiro (FAPERJ) (202.944/2015). NW was
   supported by a postdoctoral fellowship from Diabetes Canada.
CR Ahmed T, 2014, NEUROBIOL AGING, V35, P2474, DOI 10.1016/j.neurobiolaging.2014.05.005
   [Anonymous], ALZHEIMERS DEMENT
   Anyan J, 2018, NEUROPSYCHOPHARMACOL, V43, P931, DOI 10.1038/npp.2017.260
   ARRIAGADA PV, 1992, NEUROLOGY, V42, P1681, DOI 10.1212/WNL.42.9.1681
   Asakawa A, 2003, J DIABETES COMPLICAT, V17, P105, DOI 10.1016/S1056-8727(02)00185-X
   Barker GRI, 2007, J NEUROSCI, V27, P2948, DOI 10.1523/JNEUROSCI.5289-06.2007
   Benedict C, 2012, DIABETES CARE, V35, P488, DOI 10.2337/dc11-2075
   Biallosterski BT, 2015, FRONT AGING NEUROSCI, V7, DOI 10.3389/fnagi.2015.00160
   Biundo F, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-21596-3
   BRAAK H, 1991, ACTA NEUROPATHOL, V82, P239, DOI 10.1007/BF00308809
   Braak H, 2006, ACTA NEUROPATHOL, V112, P389, DOI 10.1007/s00401-006-0127-z
   Can A, 2012, JOVE-J VIS EXP, DOI 10.3791/3769
   Castillo-Carranza DL, 2014, J ALZHEIMERS DIS, V40, pS97, DOI 10.3233/JAD-132477
   Cernea S, 2019, PSYCHIAT CLIN NEUROS, V73, P745, DOI 10.1111/pcn.12922
   CLEVELAND DW, 1977, J MOL BIOL, V116, P207, DOI 10.1016/0022-2836(77)90213-3
   Congdon EE, 2018, NAT REV NEUROL, V14, P399, DOI 10.1038/s41582-018-0013-z
   Dawson HN, 2010, NEUROSCIENCE, V169, P516, DOI 10.1016/j.neuroscience.2010.04.037
   Dawson HN, 2001, J CELL SCI, V114, P1179
   Donovan NJ, 2018, AM J PSYCHIAT, V175, P530, DOI 10.1176/appi.ajp.2017.17040442
   Dugger BN, 2016, J ALZHEIMERS DIS, V54, P1249, DOI 10.3233/JAD-169007
   Durk MR, 2014, J NEUROSCI, V34, P7091, DOI 10.1523/JNEUROSCI.2711-13.2014
   Ekblad LL, 2017, DIABETES CARE, V40, P751, DOI 10.2337/dc16-2001
   Estanislau C, 2011, BEHAV PROCESS, V86, P46, DOI 10.1016/j.beproc.2010.08.008
   Figueiredo CP, 2013, J NEUROSCI, V33, P9626, DOI 10.1523/JNEUROSCI.0482-13.2013
   Finger BC, 2010, PSYCHOPHARMACOLOGY, V210, P559, DOI 10.1007/s00213-010-1858-z
   Fortuna JTS, 2017, BEHAV BRAIN RES, V333, P150, DOI 10.1016/j.bbr.2017.06.047
   Geda YE, 2014, AM J PSYCHIAT, V171, P572, DOI 10.1176/appi.ajp.2014.13060821
   GRUNDKEIQBAL I, 1986, J BIOL CHEM, V261, P6084
   Gu YJ, 1996, J NEUROCHEM, V67, P1235
   Guillozet AL, 2003, ARCH NEUROL-CHICAGO, V60, P729, DOI 10.1001/archneur.60.5.729
   HARADA A, 1994, NATURE, V369, P488, DOI 10.1038/369488a0
   Hernández F, 2019, BBA-MOL BASIS DIS, V1865, P2024, DOI 10.1016/j.bbadis.2018.08.010
   Ikegami S, 2000, NEUROSCI LETT, V279, P129, DOI 10.1016/S0304-3940(99)00964-7
   Ikura Y, 1998, NEUROREPORT, V9, P2375, DOI 10.1097/00001756-199807130-00041
   Janson J, 2004, DIABETES, V53, P474, DOI 10.2337/diabetes.53.2.474
   Kahl KG, 2015, BRAIN BEHAV, V5, DOI 10.1002/brb3.306
   Ke Yazi D, 2012, Int J Alzheimers Dis, V2012, P873270, DOI 10.1155/2012/873270
   KENNER L, 1994, HEPATOLOGY, V20, P1086, DOI 10.1002/hep.1840200442
   Kimura T, 2014, PHILOS T R SOC B, V369, DOI 10.1098/rstb.2013.0144
   Kleinridders A, 2015, P NATL ACAD SCI USA, V112, P3463, DOI 10.1073/pnas.1500877112
   Lasagna-Reeves CA, 2012, FASEB J, V26, P1946, DOI 10.1096/fj.11-199851
   Lasagna-Reeves CA, 2011, MOL NEURODEGENER, V6, DOI 10.1186/1750-1326-6-39
   Ledo JH, 2013, MOL PSYCHIATR, V18, P1053, DOI 10.1038/mp.2012.168
   Ledo JH, 2016, J NEUROSCI, V36, P12106, DOI 10.1523/JNEUROSCI.1269-16.2016
   Lei P, 2014, MOL NEURODEGENER, V9, DOI 10.1186/1750-1326-9-29
   Lei P, 2012, NAT MED, V18, P291, DOI 10.1038/nm.2613
   Licinio J, 2014, TRANSL PSYCHIAT, V4, DOI 10.1038/tp.2014.115
   Liu J, 2010, PSYCHOPHARMACOLOGY, V207, P535, DOI 10.1007/s00213-009-1684-3
   Lourenco MV, 2013, CELL METAB, V18, P831, DOI 10.1016/j.cmet.2013.11.002
   Luchsinger JA, 2004, NEUROLOGY, V63, P1187, DOI 10.1212/01.WNL.0000140292.04932.87
   Ma QL, 2014, J NEUROSCI, V34, P7124, DOI 10.1523/JNEUROSCI.3439-13.2014
   Maeda S, 2006, NEUROSCI RES, V54, P197, DOI 10.1016/j.neures.2005.11.009
   Mah L, 2015, AM J GERIAT PSYCHIAT, V23, P466, DOI 10.1016/j.jagp.2014.10.005
   Marciniak E, 2017, J EXP MED, V214, P2257, DOI 10.1084/jem.20161731
   Marschner A, 2008, J NEUROSCI, V28, P9030, DOI 10.1523/JNEUROSCI.1651-08.2008
   Morris M, 2013, NEUROBIOL AGING, V34, P1523, DOI 10.1016/j.neurobiolaging.2012.12.003
   Murakami T, 2006, AM J PATHOL, V169, P1365, DOI 10.2353/ajpath.2006.051250
   Neergaard JS, 2017, DIABETES, V66, P1957, DOI 10.2337/db16-1444
   NISHIMURA H, 1989, PHARMACOL BIOCHEM BE, V33, P227, DOI 10.1016/0091-3057(89)90454-1
   Ott A, 1999, NEUROLOGY, V53, P1937, DOI 10.1212/WNL.53.9.1937
   PHILLIPS RG, 1992, BEHAV NEUROSCI, V106, P274, DOI 10.1037/0735-7044.106.2.274
   Poleszak E, 2019, NEUROTOX RES, V35, P344, DOI 10.1007/s12640-018-9959-2
   Pooler AM, 2014, NEUROPHARMACOLOGY, V76, P1, DOI 10.1016/j.neuropharm.2013.09.018
   PORSOLT RD, 1978, EUR J PHARMACOL, V47, P379, DOI 10.1016/0014-2999(78)90118-8
   Prut L, 2003, EUR J PHARMACOL, V463, P3, DOI 10.1016/S0014-2999(03)01272-X
   Rebolledo-Solleiro Daniela, 2017, PLoS One, V12, pe0176554, DOI 10.1371/journal.pone.0176554
   SHEPHERD JK, 1994, PSYCHOPHARMACOLOGY, V116, P56, DOI 10.1007/BF02244871
   Soto M, 2019, P NATL ACAD SCI USA, V116, P6379, DOI 10.1073/pnas.1817391116
   Sunyer B., 2007, NatProtocols, DOI DOI 10.1038/NPROT.2007.390
   Tan DCS, 2018, J ALZHEIMERS DIS, V62, P571, DOI 10.3233/JAD-171058
   Teri L, 1999, J GERONTOL A-BIOL, V54, pM348, DOI 10.1093/gerona/54.7.M348
   Velazquez R, 2018, AGING CELL, V17, DOI 10.1111/acel.12775
   WEINGARTEN MD, 1975, P NATL ACAD SCI USA, V72, P1858, DOI 10.1073/pnas.72.5.1858
   Wijesekara N, 2018, FASEB J, V32, P3166, DOI 10.1096/fj.201701352
   Wijesekara N, 2018, NEUROPHARMACOLOGY, V136, P172, DOI 10.1016/j.neuropharm.2017.11.027
   Xu WL, 2009, DIABETOLOGIA, V52, P1031, DOI 10.1007/s00125-009-1323-x
   Yaffe K, 2007, ALZ DIS ASSOC DIS, V21, P167, DOI 10.1097/WAD.0b013e318065bfd6
   Yaffe K, 2012, ARCH NEUROL-CHICAGO, V69, P1170, DOI 10.1001/archneurol.2012.1117
   Zarrindast MR, 2015, ARCH IRAN MED, V18, P591, DOI 0151809/AIM.009
NR 79
TC 31
Z9 34
U1 0
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAR 12
PY 2020
VL 11
AR 124
DI 10.3389/fendo.2020.00124
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA LD0CZ
UT WOS:000525702500001
PM 32226410
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU He, ZB
   Yin, GC
   Li, QQ
   Zeng, QF
   Duan, JL
AF He, Zubin
   Yin, Guochao
   Li, Qingdi Quentin
   Zeng, Qiongfang
   Duan, Jinliang
TI Diabetes Mellitus Causes Male Reproductive Dysfunction: A Review of the
   Evidence and Mechanisms
SO IN VIVO
LA English
DT Review
DE Diabetes mellitus; male fertility; male sexual dysfunction; male
   reproductive dysfunction; influencing mechanism; review
ID INSULIN-RESISTANCE; TESTOSTERONE; THERAPY; DAMAGE; GIRLS; RISK; GNRH;
   MEN
AB The metabolic disorders caused by diabetes can lead to various complications, including dysfunction of the male reproductive system. In patients with diabetes, long-term hyperglycemia results in diabetic vascular neuropathy, oxidative stress injury, abnormal zinc metabolism, and insulin resistance syndrome. In addition, insulin deficiency and resistance in diabetes can damage the hypothalamus, pituitary gland, gonads, and perigonads. This can reduce the secretion of sex hormones including gonadotropin-releasing hormone, follicle stimulating hormone, luteinizing hormone, and testosterone, and can lead to testicular atrophy, stromal cell atrophy, seminiferous tubule damage, spermatogenic cell damage, and other structural injuries of the male reproductive organs. These actions can affect male fertility and reproductive health. Herein, we review studies that report a causative role of diabetes in male reproductive function. We also discuss the evidence-based mechanisms involved in the processes of diabetes-related male sexual and reproductive dysfunction as well as the progress in treatment.
C1 [He, Zubin; Zeng, Qiongfang; Duan, Jinliang] 924 Hosp PLA Joint Logist Support Force, 1 Xinqiaoyuan Rd, Guilin 541002, Peoples R China.
   [Yin, Guochao] Guilin Rehabil & Recuperat Ctr, Guilin, Peoples R China.
   [Li, Qingdi Quentin] NIEHS, Sci Review Branch, Div Extramural Res & Training, NIH, Durham, NC USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Environmental Health Sciences (NIEHS)
RP Duan, JL (corresponding author), 924 Hosp PLA Joint Logist Support Force, 1 Xinqiaoyuan Rd, Guilin 541002, Peoples R China.
EM dj16342@21can.com
FU Guilin Scientific Research and Technology Development Plan [17js008]; 
   [20180106-4-7]
FX This work was supported by a grant for Omics evaluation and high
   precision genetic screening of embryo implantation potential in officers
   and soldiers of the PLA (No. 17js008) and a grant by Guilin Scientific
   Research and Technology Development Plan (No. 20180106-4-7). The Authors
   would also like to thank Diane Cooper, NIH Library, for reviewing the
   article.
CR Baldauff NH, 2017, CURR OPIN ENDOCRINOL, V24, P56, DOI 10.1097/MED.0000000000000309
   Brown RJ, 2017, J CLIN ENDOCR METAB, V102, P1789, DOI 10.1210/jc.2016-3674
   Cai X, 2014, ASIAN J ANDROL, V16, P146, DOI 10.4103/1008-682X.122346
   Cai YM, 2018, J MOL HISTOL, V49, P133, DOI 10.1007/s10735-017-9753-0
   [曹荟哲 Cao Huizhe], 2017, [解放军医学杂志, Medical Journal of Chinese People's Liberation Army], V42, P81
   Castela A, 2016, NAT REV UROL, V13, P266, DOI 10.1038/nrurol.2016.23
   Chen Xin, 2018, Zhonghua Nan Ke Xue, V24, P529
   Cree-Green M, 2015, AM J PHYSIOL-ENDOC M, V308, pE726, DOI 10.1152/ajpendo.00619.2014
   Cui X, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19113634
   Deng P, 2019, CHIN J FAM PLAN, V27, P21, DOI [10.3969/j. issn.1004-8189.2019.01.005, DOI 10.3969/J.ISSN.1004-8189.2019.01.005]
   Fung EB, 2015, NUTRIENTS, V7, P4296, DOI 10.3390/nu7064296
   [郭亚莉 Guo Yali], 2020, [中国糖尿病杂志, Chinese Journal of Diabetes], V28, P788
   Hannan MA, 2017, THERIOGENOLOGY, V88, P228, DOI 10.1016/j.theriogenology.2016.09.032
   Hu M, 2017, J MODERN MED HLTH, V33, P1158, DOI [10.3969/j.issn.1009-5519.2017.08.013, DOI 10.3969/J.ISSN.1009-5519.2017.08.013]
   Imani M, 2021, J OBSTET GYNAECOL, V41, P439, DOI 10.1080/01443615.2020.1744114
   Jurowski K, 2014, J BIOL INORG CHEM, V19, P1069, DOI 10.1007/s00775-014-1139-0
   Kaur G, 2018, DNA CELL BIOL, V37, P680, DOI 10.1089/dna.2017.3937
   Khera M, 2015, J SEX MED, V12, P1105, DOI 10.1111/jsm.12871
   Kim M, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/3239649
   Li F, 2018, CHIN J HUM SEX, V27, P10, DOI [10.3969/j. issn.1672- 1993.2018.03.002, DOI 10.3969/J.ISSN.1672-1993.2018.03.002]
   Li Y, 2020, Chinese General Medicine, V18, P1729, DOI DOI 10.16766/J.CNKI.ISSN.1674-4152.001605
   Lin J, 2018, MOL MECH SPERMATOGEN, DOI [10.7666/d.Y3514107, DOI 10.7666/D.Y3514107]
   Liu JS, 2017, FOOD FUNCT, V8, P695, DOI 10.1039/c6fo01616b
   Liu W, 2020, CHIN J ANDROL, V34
   Lorigo M, 2020, J CARDIOVASC TRANSL, V13, P55, DOI 10.1007/s12265-019-09939-5
   Ma Jing, 2018, Zhonghua Nan Ke Xue, V24, P695
   Ma Z, 2016, MED FORUM, V20, P5075, DOI [10.3969/j. issn.1672-1721.2016.36.005, DOI 10.3969/J.ISSN.1672-1721.2016.36.005]
   Maresch CC, 2018, HUM REPROD UPDATE, V24, P86, DOI 10.1093/humupd/dmx033
   Öztin H, 2016, GYNECOL ENDOCRINOL, V32, P991, DOI 10.1080/09513590.2016.1214258
   Qadir MMF, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20215423
   Sahin N, 2019, J BIOCHEM MOL TOXIC, V33, DOI 10.1002/jbt.22328
   Sahu SK, 2017, AUST VET J, V95, P281, DOI 10.1111/avj.12611
   Salminen M, 2015, GERIATR GERONTOL INT, V15, P559, DOI 10.1111/ggi.12312
   Shi GJ, 2017, BIOMED PHARMACOTHER, V90, P562, DOI 10.1016/j.biopha.2017.03.074
   Song HG, 2019, J CELL PHYSIOL, V234, P23774, DOI 10.1002/jcp.28945
   Taravati A, 2016, ANDROLOGIA, V48, P646, DOI 10.1111/and.12494
   Usui T, 2014, FEBS LETT, V588, P1935, DOI 10.1016/j.febslet.2014.03.051
   Verit A, 2014, ARCH ITAL UROL ANDRO, V86, P5, DOI 10.4081/aiua.2014.1.5
   Wang FY, 2015, J ENDOCRINOL, V225, P101, DOI 10.1530/JOE-14-0638
   Wang XM, 2014, CELL PHYSIOL BIOCHEM, V34, P658, DOI 10.1159/000363031
   Xia FZ, 2013, REPROD BIOL ENDOCRIN, V11, DOI 10.1186/1477-7827-11-106
   Yang X, 2019, MOL MED REP, V20, P1230, DOI 10.3892/mmr.2019.10347
   Zhang C, 2017, CHIN J CLIN RES, V30, P744, DOI [10.13429/j.cnki.cjcr.2017.06.007, DOI 10.13429/J.CNKI.CJCR.2017.06.007]
   Zhang JG, 2013, DIABETES-METAB RES, V29, P391, DOI 10.1002/dmrr.2405
   [赵雯 Zhao Wen], 2020, [中山大学学报. 医学科学版, Journal of Sun Yat-sen University. Medical Sciences], V41, P260
   Zhong M, 2012, PROG ANAT SCI, V18, P12, DOI [10.16695/ j.cnki.1006-2947.2012.01.012, DOI 10.16695/J.CNKI.1006-2947.2012.01.012]
NR 46
TC 56
Z9 62
U1 0
U2 29
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22,
   ATHENS 19014, GREECE
SN 0258-851X
EI 1791-7549
J9 IN VIVO
JI In Vivo
PD SEP-OCT
PY 2021
VL 35
IS 5
BP 2503
EP 2511
DI 10.21873/invivo.12531
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA UC8AR
UT WOS:000686745300001
PM 34410936
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yu, ZQ
   Bai, XY
   Ruan, GC
   Han, W
   Yang, H
AF Yu, Ziqing
   Bai, Xiaoyin
   Ruan, Gechong
   Han, Wei
   Yang, Hong
TI Association between generalized anxiety disorder and live microbes
   intake in the United States general population
SO CURRENT PSYCHOLOGY
LA English
DT Article
DE Generalized anxiety disorder; Live microbes; Anxiety; Dietary
ID METABOLIC SYNDROME; PROBIOTICS; PREBIOTICS
AB Generalized Anxiety Disorder (GAD) is the most common anxiety disorder in primary care, affecting approximately 7% of US adults. Probiotics have been found to alleviate symptoms in GAD, but the relationship between dietary live microbes and GAD remains unclear. Our aim is to determine the relationship between the dietary live microbe consumption and GAD. We included 54 GAD patients from the National Health and Nutrition Examination Survey and selected controls using a 1:4 propensity score matching. The diagnosis of GAD was based on the fourth edition of the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders. The live microbe intake was calculated based on expert-specified estimates of food [low (Lo), < 104 CFU/g; medium (Med), 104-107 CFU/g; or high (Hi), > 107 CFU/g].We observed a significant reduction in Med foods intake among GAD patients compared with controls (OR: 0.44, CI: 0.21-0.92, p = 0.03), also lower household income. Additionally, higher intake of Med foods correlated with a lower risk of GAD in males (OR: 0.26, CI: 0.08-0.84, p = 0.03), individuals with <= High school education (OR: 0.37, CI: 0.14-0.95, p = 0.04), non-hypertensive participants (OR: 0.37, CI: 0.16-0.87, p = 0.02), and drinkers (OR: 0.41, CI: 0.19-0.89, p = 0.03). Consuming more Med foods like fruits and vegetables may be a protective factor for GAD and could aid in future dietary management. Additionally, GAD patients require more financial and social support.
C1 [Yu, Ziqing; Bai, Xiaoyin; Ruan, Gechong; Yang, Hong] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Gastroenterol, Beijing 100730, Peoples R China.
   [Han, Wei] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Epidemiol & Biostat, Beijing 100730, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital; Peking Union Medical College;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital
RP Yang, H (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Gastroenterol, Beijing 100730, Peoples R China.
EM yangh@pumch.cn
RI Yu, Ziqing/JZD-6300-2024
FU Capital Health Research and Development of Special Foundation
FX No Statement Available
CR Agagündüz D, 2023, PROBIOTICS ANTIMICRO, V15, P1014, DOI 10.1007/s12602-023-10092-4
   Amirani E, 2020, COMPLEMENT THER MED, V49, DOI 10.1016/j.ctim.2020.102361
   Andrioaie IM, 2022, MICROORGANISMS, V10, DOI 10.3390/microorganisms10122436
   [Anonymous], 2019, ANN INTERN MED, V170, pITC49, DOI 10.7326/AITC201904020
   [Anonymous], 2014, DIABETES RES CLIN PR, V104, P1, DOI 10.1016/j.diabres.2012.10.001
   Aucoin M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124418
   Chen Y, 2019, AM J CLIN NUTR, V109, P1611, DOI 10.1093/ajcn/nqy358
   Chen YH, 2019, J AFFECT DISORDERS, V259, P56, DOI 10.1016/j.jad.2019.08.014
   Chodavadia P, 2023, BMC PSYCHIATRY, V23, DOI 10.1186/s12888-023-04581-7
   Coletro HN, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.1042425
   Dehghani F, 2023, NUTR NEUROSCI, V26, P942, DOI 10.1080/1028415X.2022.2110664
   Dinan TG, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0292-1
   Doney E, 2022, EUR J NEUROSCI, V55, P2851, DOI 10.1111/ejn.15239
   Eskandarzadeh S, 2021, NUTR NEUROSCI, V24, P102, DOI 10.1080/1028415X.2019.1598669
   Gao J, 2023, FRONT CELL INFECT MI, V13, DOI 10.3389/fcimb.2023.1167116
   Glabska D, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010115
   Grant BF, 2005, PSYCHOL MED, V35, P1747, DOI 10.1017/S0033291705006069
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Hepsomali P, 2021, NUTRIENTS, V13, DOI 10.3390/nu13082573
   Hill C, 2014, NAT REV GASTRO HEPAT, V11, P506, DOI 10.1038/nrgastro.2014.66
   Jiang HY, 2018, J PSYCHIATR RES, V104, P130, DOI 10.1016/j.jpsychires.2018.07.007
   Kang SS, 2014, MOL NEURODEGENER, V9, DOI 10.1186/1750-1326-9-36
   Konnopka A, 2020, PHARMACOECONOMICS, V38, P25, DOI 10.1007/s40273-019-00849-7
   Kosov ME., 2023, EMERGING SCI J, V7, P49, DOI [10.28991/ESJ-2023-SIED2-05, DOI 10.28991/ESJ-2023-SIED2-05]
   Kujanpää T, 2016, SCAND J PRIM HEALTH, V34, P151, DOI 10.3109/02813432.2016.1160631
   Liu RT, 2019, NEUROSCI BIOBEHAV R, V102, P13, DOI 10.1016/j.neubiorev.2019.03.023
   Mahdavifar B, 2022, NUTR NEUROSCI, V25, P2379, DOI 10.1080/1028415X.2021.1969065
   Marco ML, 2022, J NUTR, V152, P1729, DOI 10.1093/jn/nxac074
   Marco ML, 2020, J NUTR, V150, P3061, DOI 10.1093/jn/nxaa323
   Nam T. T., 2023, Journal of Human Earth and Future, V4, P453, DOI [10.28991/HEF-2023-04-04-06, DOI 10.28991/HEF-2023-04-04-06]
   Tran N, 2019, J AFFECT DISORDERS, V252, P271, DOI 10.1016/j.jad.2019.04.043
   Ramos-Galarza, 2023, EMERGING SCI J, V7, P79, DOI [10.28991/ESJ-2023-SIED2-07, DOI 10.28991/ESJ-2023-SIED2-07]
   Rees J, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051447
   Revicki DA, 2012, J AFFECT DISORDERS, V140, P103, DOI 10.1016/j.jad.2011.11.014
   Salleh RM, 2021, NUTRIENTS, V13, DOI 10.3390/nu13061783
   Sangsefidi ZS, 2020, BMC PSYCHIATRY, V20, DOI 10.1186/s12888-020-02678-x
   Semnani-Azad Z, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.9993
   Taylor AM, 2020, NUTR NEUROSCI, V23, P237, DOI 10.1080/1028415X.2018.1493808
   Valcarce DG, 2020, HELIYON, V6, DOI 10.1016/j.heliyon.2020.e03973
   Whelton Paul K, 2018, Hypertension, V71, pe13, DOI [10.1016/j.jash.2018.06.010, 10.1161/HYP.0000000000000065]
   Zhang XX, 2021, NUTR METAB, V18, DOI 10.1186/s12986-020-00527-y
NR 41
TC 0
Z9 0
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1046-1310
EI 1936-4733
J9 CURR PSYCHOL
JI Curr. Psychol.
PD SEP
PY 2024
VL 43
IS 35
BP 28342
EP 28351
DI 10.1007/s12144-024-06514-3
EA AUG 2024
PG 10
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA G8M9E
UT WOS:001295795900002
DA 2025-06-11
ER

PT J
AU Shaffer, C
   Westlin, C
   Quigley, KS
   Whitfield-Gabrieli, S
   Barrett, LF
AF Shaffer, Clare
   Westlin, Christiana
   Quigley, Karen S.
   Whitfield-Gabrieli, Susan
   Barrett, Lisa Feldman
TI Allostasis, Action, and Affect in Depression: Insights from the Theory
   of Constructed Emotion
SO ANNUAL REVIEW OF CLINICAL PSYCHOLOGY
LA English
DT Article
DE metabolism; affect; emotion; interoception; predictive processing;
   allostasis; depression
ID FUNCTIONAL CONNECTIVITY; SIGNALING MECHANISMS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; NERVOUS-SYSTEM; RHESUS-MONKEY; BRAIN; MODEL; CORTEX;
   PERCEPTION
AB The theory of constructed emotion is a systems neuroscience approach to understanding the nature of emotion. It is also a general theoretical framework to guide hypothesis generation for how actions and experiences are constructed as the brain continually anticipates metabolic needs and attempts to meet those needs before they arise (termed allostasis). In this review, we introduce this framework and hypothesize that allostatic dysregulation is a trans-disorder vulnerability for mental and physical illness. We then review published findings consistent with the hypothesis that several symptoms in major depressive disorder (MDD), such as fatigue, distress, context insensitivity, reward insensitivity, and motor retardation, are associated with persistent problems in energy regulation. Our approach transforms the current understanding of MDD as resulting from enhanced emotional reactivity combined with reduced cognitive control and, in doing so, offers novel hypotheses regarding the development, progression, treatment, and prevention of MDD.
C1 [Shaffer, Clare; Westlin, Christiana; Quigley, Karen S.; Whitfield-Gabrieli, Susan; Barrett, Lisa Feldman] Northeastern Univ, Dept Psychol, Boston, MA 02115 USA.
   [Whitfield-Gabrieli, Susan] MIT, Dept Brain & Cognit Sci, E25-618, Cambridge, MA 02139 USA.
   [Barrett, Lisa Feldman] Massachusetts Gen Hosp, Dept Psychiat, Charlestown, MA USA.
   [Barrett, Lisa Feldman] Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA.
   [Barrett, Lisa Feldman] Harvard Med Sch, Charlestown, MA USA.
   [Quigley, Karen S.] VA Bedford Healthcare Syst, Bedford, MA USA.
C3 Northeastern University; Massachusetts Institute of Technology (MIT);
   Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital
RP Shaffer, C (corresponding author), Northeastern Univ, Dept Psychol, Boston, MA 02115 USA.
EM shaffer.c@northeastern.edu; l.barrett@northeastern.edu
RI Westlin, Christiana/LKO-3951-2024; Quigley, Karen/B-9003-2013; Barrett,
   Lisa/ABC-8157-2020
OI Westlin, Christiana/0000-0001-9127-0847; Shaffer,
   Clare/0000-0002-3977-6151; Barrett, Lisa/0000-0003-4478-2051
FU National Cancer Institute [U01CA193632]; National Institute of Mental
   Health [R01MH113234, R01MH109464]; National Institute on Aging
   [R56AG058745]; National Science Foundation [BCS1947972]; Elizabeth R.
   Koch Foundation; US Army Research Institute for the Behavioral and
   Social Sciences [W911NF-16-1-019]; National Institute of Mental Health
   [R01MH113234, R01MH109464] Funding Source: NIH RePORTER
FX The authors thank Nate McLaughlin and Francesca Morfini for their
   assistance in summarizing the neuroimaging and biomarker literature on
   depression. The writing of this review was supported by funding from the
   National Cancer Institute (U01CA193632), the National Institute of
   Mental Health (R01MH113234, R01MH109464), the National Institute on
   Aging (R56AG058745), the National Science Foundation (BCS1947972), and
   the Elizabeth R. Koch Foundation (through its Unlikely Collaborators
   Fund) to L.F.B. and by the US Army Research Institute for the Behavioral
   and Social Sciences (W911NF-16-1-019) to K.S.Q.
CR Abdallah CG, 2017, BIOL PSYCHIAT-COGN N, V2, P566, DOI 10.1016/j.bpsc.2017.04.006
   Adolphs R, 2017, SOC COGN AFFECT NEUR, V12, P24, DOI 10.1093/scan/nsw153
   Allen J, 2018, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00386
   [Anonymous], 1975, Cross-Cultural universals of affective meaning
   Ashby WR., 1960, Design for a Brain: The Origin of Adaptive Behaviour
   Atzil S, 2018, NAT HUM BEHAV, V2, P624, DOI 10.1038/s41562-018-0384-6
   Avery JA, 2015, HUM BRAIN MAPP, V36, P2996, DOI 10.1002/hbm.22823
   Bär KJ, 2016, NEUROIMAGE, V134, P53, DOI 10.1016/j.neuroimage.2016.03.071
   Bansal Y, 2016, CURR NEUROPHARMACOL, V14, P610, DOI 10.2174/1570159X14666160229114755
   BARBAS H, 1986, J COMP NEUROL, V252, P415, DOI 10.1002/cne.902520310
   Barbas H, 2015, ANNU REV NEUROSCI, V38, P269, DOI 10.1146/annurev-neuro-071714-033936
   Barrett L. F., 2018, How emotions are made: The secret life of the brain, P56
   Barrett LF, 2006, PERS SOC PSYCHOL REV, V10, P20, DOI 10.1207/s15327957pspr1001_2
   Barrett LF, 2007, ANNU REV PSYCHOL, V58, P373, DOI 10.1146/annurev.psych.58.110405.085709
   Barrett LF, 2019, PSYCHOL SCI PUBL INT, V20, P1, DOI 10.1177/1529100619832930
   Barrett LF, 2018, CURR OPIN BEHAV SCI, V24, P172, DOI 10.1016/j.cobeha.2018.10.001
   Barrett LF, 2017, SOC COGN AFFECT NEUR, V12, P1, DOI [10.1093/scan/nsw154, 10.1093/scan/nsx060]
   Barrett LF, 2016, PHILOS T R SOC B, V371, DOI 10.1098/rstb.2016.0011
   Barrett LF, 2015, NAT REV NEUROSCI, V16, P419, DOI 10.1038/nrn3950
   Barrett LF, 2013, EMOT REV, V5, P379, DOI 10.1177/1754073913489753
   Barrett LF, 2013, CURR OPIN NEUROBIOL, V23, P361, DOI 10.1016/j.conb.2012.12.012
   Barrett LF, 2012, EMOTION, V12, P413, DOI 10.1037/a0027555
   Barrett LF, 2009, ADV EXP SOC PSYCHOL, V41, P167, DOI 10.1016/S0065-2601(08)00404-8
   Barsalou LW, 2008, ANNU REV PSYCHOL, V59, P617, DOI 10.1146/annurev.psych.59.103006.093639
   Barsalou LW, 2003, LANG COGNITIVE PROC, V18, P513, DOI 10.1080/01690960344000026
   Barsalou LW, 2003, TRENDS COGN SCI, V7, P84, DOI 10.1016/S1364-6613(02)00029-3
   BARSALOU LW, 1983, MEM COGNITION, V11, P211, DOI 10.3758/BF03196968
   Bayer S., 2004, The rat nervous system, P27, DOI DOI 10.1016/B978-012547638-6/50003-1
   Bechtel W, 2021, PHILOS T R SOC B, V376, DOI 10.1098/rstb.2019.0751
   Beeler JA, 2012, FRONT INTEGR NEUROSC, V6, DOI 10.3389/fnint.2012.00049
   Bennett D, 2022, PSYCHOL REV, V129, P513, DOI 10.1037/rev0000294
   Berkes P, 2011, SCIENCE, V331, P83, DOI 10.1126/science.1195870
   Blessing WW, 1997, TRENDS NEUROSCI, V20, P235, DOI 10.1016/S0166-2236(96)01029-6
   BRAND JG, 1982, ANNU REV NUTR, V2, P249, DOI 10.1146/annurev.nu.02.070182.001341
   Buckner RL, 2012, NEUROIMAGE, V62, P1137, DOI 10.1016/j.neuroimage.2011.10.035
   Cacciola A, 2019, BRAIN STRUCT FUNCT, V224, P2153, DOI 10.1007/s00429-019-01893-x
   Cai XY, 2012, J NEUROSCI, V32, P3791, DOI 10.1523/JNEUROSCI.3864-11.2012
   Cappaert NL., 2015, RAT NERVOUS SYSTEM, VFourth, P511, DOI DOI 10.1016/B978-0-12-374236-0.10024-0
   CAVADA C, 1989, J COMP NEUROL, V287, P393, DOI 10.1002/cne.902870402
   Cavalier M, 2010, DIABETES CARE, V33, P2489, DOI 10.2337/dc10-0851
   Chan O, 2005, ENDOCRINOLOGY, V146, P1382, DOI 10.1210/en.2004-0607
   Chanes L, 2016, TRENDS COGN SCI, V20, P96, DOI 10.1016/j.tics.2015.11.005
   Clore G.L., 2008, Handbook of emotions
   COHEN AH, 1992, BRAIN BEHAV EVOLUT, V40, P112, DOI 10.1159/000113907
   Cohen MX, 2008, NEUROIMAGE, V39, P1396, DOI 10.1016/j.neuroimage.2007.10.004
   Cowen AS, 2017, P NATL ACAD SCI USA, V114, pE7900, DOI 10.1073/pnas.1702247114
   Craig AD, 2003, CURR OPIN NEUROBIOL, V13, P500, DOI 10.1016/S0959-4388(03)00090-4
   Crossley NA, 2014, BRAIN, V137, P2382, DOI 10.1093/brain/awu132
   Dantzer R, 2017, CURR TOP BEHAV NEURO, V31, P1, DOI 10.1007/978-3-319-51152-8
   Dantzer R, 2014, TRENDS NEUROSCI, V37, P39, DOI 10.1016/j.tins.2013.10.003
   Deneve S, 2008, NEURAL COMPUT, V20, P91, DOI 10.1162/neco.2008.20.1.91
   Denève S, 2017, NEURON, V94, P969, DOI 10.1016/j.neuron.2017.05.016
   DeRubeis RJ, 2008, NAT REV NEUROSCI, V9, P788, DOI 10.1038/nrn2345
   Disner SG, 2011, NAT REV NEUROSCI, V12, P467, DOI 10.1038/nrn3027
   Edelman GM, 2001, P NATL ACAD SCI USA, V98, P13763, DOI 10.1073/pnas.231499798
   Everson-Rose SA, 2004, DIABETES CARE, V27, P2856, DOI 10.2337/diacare.27.12.2856
   EYKHOFF P, 1994, MODEL IDENT CONTROL, V15, P135, DOI 10.4173/mic.1994.3.2
   Fattal O, 2007, CNS SPECTRUMS, V12, P429, DOI 10.1017/S1092852900015303
   Feillet CA, 2010, J NEUROENDOCRINOL, V22, P620, DOI 10.1111/j.1365-2826.2010.01998.x
   Felger JC, 2007, BIOL PSYCHIAT, V62, P1324, DOI 10.1016/j.biopsych.2007.05.026
   Fernandino L, 2016, CEREB CORTEX, V26, P2018, DOI 10.1093/cercor/bhv020
   Fried E, 2017, EXPERT REV NEUROTHER, V17, P423, DOI 10.1080/14737175.2017.1307737
   Frijda N., 1986, Studies in Emotion and Social Interaction
   Friston KJ, 2010, NAT REV NEUROSCI, V11, P127, DOI 10.1038/nrn2787
   Friston KJ, 2003, NEURAL NETWORKS, V16, P1325, DOI 10.1016/j.neunet.2003.06.005
   Gans ROB, 2006, MED CLIN N AM, V90, P573, DOI 10.1016/j.mcna.2006.05.002
   García-Cabezas MA, 2019, BRAIN STRUCT FUNCT, V224, P985, DOI 10.1007/s00429-019-01841-9
   Gee H., 2018, Across the bridge: Understanding the origin of the vertebrates
   Gendron M., 2020, CULTURE MIND BRAIN E, P188
   Goldberg D, 2011, WORLD PSYCHIATRY, V10, P226
   Haber SN, 2003, J CHEM NEUROANAT, V26, P317, DOI 10.1016/j.jchemneu.2003.10.003
   Hasler G, 2007, ARCH GEN PSYCHIAT, V64, P193, DOI 10.1001/archpsyc.64.2.193
   Hassabis D, 2009, PHILOS T R SOC B, V364, P1263, DOI 10.1098/rstb.2008.0296
   Hillhouse TM, 2015, EXP CLIN PSYCHOPHARM, V23, P1, DOI 10.1037/a0038550
   Hoemann K, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-69180-y
   Hoemann K, 2017, CURR OPIN BEHAV SCI, V15, P51, DOI 10.1016/j.cobeha.2017.05.013
   Hroudová J, 2013, MITOCHONDRION, V13, P795, DOI 10.1016/j.mito.2013.05.005
   Hutchinson JB, 2019, CURR DIR PSYCHOL SCI, V28, P280, DOI 10.1177/0963721419831992
   Kan C, 2013, DIABETES CARE, V36, P480, DOI 10.2337/dc12-1442
   Kanai R, 2015, PHILOS T R SOC B, V370, P69, DOI 10.1098/rstb.2014.0169
   Karmiloff-Smith A, 2009, CHILD DEV PERSPECT, V3, P99, DOI 10.1111/j.1750-8606.2009.00086.x
   Katsumi Y., 2021, bioRxiv, DOI DOI 10.1101/2021.09.01.456844
   Kessler RC, 1996, BRIT J PSYCHIAT, V168, P17, DOI 10.1192/S0007125000298371
   Kleckner IR, 2017, NAT HUM BEHAV, V1, DOI 10.1038/s41562-017-0069
   Kleinridders A, 2015, P NATL ACAD SCI USA, V112, P3463, DOI 10.1073/pnas.1500877112
   Kober H, 2008, NEUROIMAGE, V42, P998, DOI 10.1016/j.neuroimage.2008.03.059
   Kolling N, 2016, NAT NEUROSCI, V19, P1280, DOI 10.1038/nn.4382
   Koren T, 2021, CELL, V184, P5902, DOI 10.1016/j.cell.2021.10.013
   Kragl PA, 2019, J NEUROSCI, V39, P6180, DOI 10.1523/JNEUROSCI.2043-18.2019
   Kumaran D, 2016, TRENDS COGN SCI, V20, P512, DOI 10.1016/j.tics.2016.05.004
   Kurby CA, 2008, TRENDS COGN SCI, V12, P72, DOI 10.1016/j.tics.2007.11.004
   LAZARUS RS, 1993, ANNU REV PSYCHOL, V44, P1, DOI 10.1146/annurev.ps.44.020193.000245
   Le Mau T, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-25352-6
   Lebrecht S, 2012, FRONT PSYCHOL, V3, DOI 10.3389/fpsyg.2012.00107
   Lemaire LA, 2021, SCI ADV, V7, DOI 10.1126/sciadv.abf7452
   Leonard BE, 2020, ACTA NEUROPSYCHIATR, V32, P1, DOI 10.1017/neu.2019.17
   Li BJ, 2018, CNS NEUROSCI THER, V24, P1004, DOI 10.1111/cns.12998
   Li JZ, 2013, P NATL ACAD SCI USA, V110, P9950, DOI 10.1073/pnas.1305814110
   Lindquist KA, 2016, CEREB CORTEX, V26, P1910, DOI 10.1093/cercor/bhv001
   Liu X, 2011, NEUROSCI BIOBEHAV R, V35, P1219, DOI 10.1016/j.neubiorev.2010.12.012
   Lustman PJ, 2000, DIABETES CARE, V23, P934, DOI 10.2337/diacare.23.7.934
   Silva NDLE, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00057
   Maes M, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-66
   MareschalD Johnson MH, 2007, NEUROCONSTRUCTIVISM
   Martins-de-Souza D, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.13
   Mayr Ernst., 1974, BOSTON COLL STUD PH, V14, P91, DOI [DOI 10.1007/978-94-010-2128-9_6, DOI 10.1007/978-94-010-2128-96]
   McIntyre Roger S, 2007, Ann Clin Psychiatry, V19, P257, DOI 10.1080/10401230701653377
   MCKELLAR S, 1981, BRAIN RES, V217, P351, DOI 10.1016/0006-8993(81)90010-X
   MORAN MA, 1987, J COMP NEUROL, V256, P88, DOI 10.1002/cne.902560108
   Müller GB, 2017, INTERFACE FOCUS, V7, DOI 10.1098/rsfs.2017.0015
   O'Donnell J, 2012, NEUROCHEM RES, V37, P2496, DOI 10.1007/s11064-012-0818-x
   Oakley RH, 2013, J ALLERGY CLIN IMMUN, V132, P1033, DOI 10.1016/j.jaci.2013.09.007
   Ochsner KN, 2009, PSYCHOL SCI, V20, P1322, DOI 10.1111/j.1467-9280.2009.02459.x
   Onat F, 2003, CEREBELLUM, V2, P263, DOI 10.1080/14734220310016187
   Ottowitz WE, 2002, HARVARD REV PSYCHIAT, V10, P86, DOI 10.1093/hrp/10.2.86
   Papez JW, 1937, ARCH NEURO PSYCHIATR, V38, P725, DOI 10.1001/archneurpsyc.1937.02260220069003
   PARENT A, 1984, AM ZOOL, V24, P783
   Paus T, 2001, NAT REV NEUROSCI, V2, P417, DOI 10.1038/35077500
   Pavlov IP, 1910, WORK DIGESTIVE GLAND
   Penninx BWJH, 2018, EUR NEUROPSYCHOPHARM, V28, pS59, DOI 10.1016/j.euroneuro.2017.12.090
   Picard M, 2015, P NATL ACAD SCI USA, V112, pE6614, DOI 10.1073/pnas.1515733112
   Pontes André Luiz Bezerra de, 2010, Psychol. Neurosci., V3, P217
   Pontzer H, 2015, ANNU REV ANTHROPOL, V44, P169, DOI 10.1146/annurev-anthro-102214-013925
   Powley TL, 2000, GUT, V47, P30
   Price JL, 2010, NEUROPSYCHOPHARMACOL, V35, P192, DOI 10.1038/npp.2009.104
   Pritchard TC, 2000, EXP NEUROL, V165, P101, DOI 10.1006/exnr.2000.7450
   Quigley KS, 2021, TRENDS NEUROSCI, V44, P29, DOI 10.1016/j.tins.2020.09.008
   Raeder MB, 2006, J CLIN PSYCHIAT, V67, P1974, DOI 10.4088/JCP.v67n1219
   Richmond LL, 2017, TRENDS COGN SCI, V21, P962, DOI 10.1016/j.tics.2017.08.005
   Riva-Posse P, 2014, BIOL PSYCHIAT, V76, P963, DOI 10.1016/j.biopsych.2014.03.029
   Rizzolatti G, 1996, COGNITIVE BRAIN RES, V3, P131, DOI 10.1016/0926-6410(95)00038-0
   ROCKLAND KS, 1979, BRAIN RES, V179, P3, DOI 10.1016/0006-8993(79)90485-2
   Rolls ET, 2019, BRAIN STRUCT FUNCT, V224, P3001, DOI 10.1007/s00429-019-01945-2
   Rolls ET, 2015, CORTEX, V62, P119, DOI 10.1016/j.cortex.2013.12.005
   RUSSELL JA, 1991, J PERS SOC PSYCHOL, V60, P37, DOI 10.1037/0022-3514.60.1.37
   Saper CB, 2002, ANNU REV NEUROSCI, V25, P433, DOI 10.1146/annurev.neuro.25.032502.111311
   Schiffer JA, 2020, ELIFE, V9, DOI 10.7554/eLife.56186
   Schwartz T L, 2004, Obes Rev, V5, P115, DOI 10.1111/j.1467-789X.2004.00139.x
   SELTZER B, 1994, J COMP NEUROL, V343, P445, DOI 10.1002/cne.903430308
   Sennesh E, 2022, BIOL PSYCHOL, V167, DOI 10.1016/j.biopsycho.2021.108242
   Shipp S, 2013, TRENDS NEUROSCI, V36, P706, DOI 10.1016/j.tins.2013.09.004
   Siegel EH, 2018, PSYCHOL BULL, V144, P343, DOI 10.1037/bul0000128
   Singh MK, 2019, HORM BEHAV, V108, P73, DOI 10.1016/j.yhbeh.2018.03.009
   Sterling P., 2015, Principles of neural design
   Sterling P, 2012, PHYSIOL BEHAV, V106, P5, DOI 10.1016/j.physbeh.2011.06.004
   Striedter G. F., 2020, Brains Through Time: A Natural History of Vertebrates, DOI DOI 10.1093/OSO/9780195125689.001.0001
   Suarez AN, 2020, BIOL PSYCHIAT, V87, P1001, DOI 10.1016/j.biopsych.2019.10.012
   Tilg H, 2006, NAT REV IMMUNOL, V6, P772, DOI 10.1038/nri1937
   Tingley D, 2018, NEURON, V98, P1229, DOI 10.1016/j.neuron.2018.04.028
   UNGER JW, 1991, PROG NEUROBIOL, V36, P343, DOI 10.1016/0301-0082(91)90015-S
   van den Heuvel MP, 2013, TRENDS COGN SCI, V17, P683, DOI 10.1016/j.tics.2013.09.012
   Versteeg RI, 2017, NEUROENDOCRINOLOGY, V105, P141, DOI 10.1159/000450549
   Wager TD, 2015, PLOS COMPUT BIOL, V11, DOI 10.1371/journal.pcbi.1004066
   Werdermann M, 2021, MOL METAB, V43, DOI 10.1016/j.molmet.2020.101112
   Whalen PJ, 1998, CURR DIR PSYCHOL SCI, V7, P177, DOI 10.1111/1467-8721.ep10836912
   Witham E, 2016, CELL REP, V14, P1641, DOI 10.1016/j.celrep.2016.01.052
   Yabut JM, 2019, ENDOCR REV, V40, P1092, DOI 10.1210/er.2018-00283
   Zacks JM, 2001, PSYCHOL BULL, V127, P3, DOI 10.1037//0033-2909.127.1.3
   Zhang JH, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-51793-7
   Zhang JH, 2020, CEREB CORTEX, V30, P1357, DOI 10.1093/cercor/bhz171
   Zhuo CJ, 2019, TRANSL PSYCHIAT, V9, DOI 10.1038/s41398-019-0680-6
NR 161
TC 40
Z9 43
U1 9
U2 51
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 USA
SN 1548-5943
EI 1548-5951
J9 ANNU REV CLIN PSYCHO
JI Annu. Rev. Clin. Psychol.
PY 2022
VL 18
BP 553
EP 580
DI 10.1146/annurev-clinpsy-081219-115627
PG 28
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA 1L3PS
UT WOS:000799204400021
PM 35534123
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Hill, L
   Lee, KC
AF Hill, Lucas
   Lee, Kelly C.
TI Pharmacotherapy Considerations in Patients with HIV and Psychiatric
   Disorders: Focus on Antidepressants and Antipsychotics
SO ANNALS OF PHARMACOTHERAPY
LA English
DT Article
ID PLACEBO-CONTROLLED TRIAL; ANTIRETROVIRAL THERAPY; INFECTED PATIENTS;
   PHARMACOKINETIC INTERACTION; EXTRAPYRAMIDAL SYMPTOMS; NONMAJOR
   DEPRESSION; HEALTHY-VOLUNTEERS; POSITIVE PATIENTS; MAJOR DEPRESSION;
   AIDS PATIENTS
AB OBJECTIVE: To review the evidence for the efficacy and safety of pharmacologic agents for the treatment of depressive and psychotic disorders in patients with HIV infection and to provide clinical considerations for the treatment of depression and psychosis in these patients.
   DATA SOURCES: PubMed was searched for articles published between 1966 and August 1, 2012, using the search terms antiretrovirals, HIV, AIDS, depression, psychosis, schizophrenia, antidepressant, antipsychotic, and individual drug names (fluoxetine, sertraline, paroxetine, citalopram, escitalopram, venlafaxine, duloxetine, mirtazapine, bupropion, haloperidol, perphenazine, fluphenazine, aripiprazole, asenapine, clozapine, iloperidone, lurasidone, olanzapine, paliperidone, quetiapine, risperidone, ziprasidone).
   STUDY SELECTION AND DATA EXTRACTION: For the purposes of evaluating efficacy data, we limited our selection to randomized placebo-controlled or active comparator-controlled trials for agents that have been used for depression and psychosis in HIV-infected patients.
   DATA SYNTHESIS: We found 11 studies for depression treatment and 1 study for psychosis treatment that met our inclusion and exclusion criteria. Selective serotonin reuptake inhibitors (SSRIs; especially fluoxetine) and tricyclic antidepressants appear to be effective in treating depressive symptoms in patients with HIV infection without affecting immune status. Testosterone, stimulants, and dehydroepiandrosterone may also be effective in subsyndromal depression; however, studies on these agents in general were limited by small sample size. There are limited data for antipsychotics, with the only controlled study found for haloperidol and chlorpromazine used for AIDS delirium. Drug-drug interactions and potentiation of metabolic syndrome are concerns for the combined use of antidepressants and antipsychotics with antiretrovirals.
   CONCLUSIONS: Larger controlled studies are needed to validate the current findings as well as expand knowledge for non-SSRI antidepressants and second-generation antipsychotics for use in HIV-infected patients.
C1 [Hill, Lucas] Univ Calif San Diego, Med Ctr, La Jolla, CA 92093 USA.
   [Lee, Kelly C.] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego
RP Lee, KC (corresponding author), Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA.
EM kellylee@ucsd.edu
RI Lee, Kelly/Q-9073-2018
OI Lee, Kelly/0000-0002-1674-4210
CR *ABB LAB, 2012, PROD INF NORV RIT
   *ABB LAB, 2012, PROD INF KAL LOP RIT
   *ASTRAZENECA PHARM, 2011, PROD INF SER QUET FU
   Aung GL, 2010, ANN PHARMACOTHER, V44, P1850, DOI 10.1345/aph.1P139
   Berger JR, 2000, J PSYCHOPHARMACOL, V14, P214, DOI 10.1177/026988110001400304
   BERTZ R, 9 C RETR OPP INF, DOI DOI 10.2165/00044011-200323100-00002
   Blashill AJ, 2012, AIDS BEHAV, V16, P2251, DOI 10.1007/s10461-011-0056-2
   Bradley M, 2012, PSYCHOSOMATICS, V53, P244, DOI 10.1016/j.psym.2011.08.005
   Breitbart W, 1996, AM J PSYCHIAT, V153, P231
   *BRIST MYERS SQ CO, 2012, PROD INF SUST EF
   Currier MB, 2004, PSYCHOSOMATICS, V45, P210, DOI 10.1176/appi.psy.45.3.210
   de Maat MM, 2003, CLIN DRUG INVEST, V23, P629, DOI 10.2165/00044011-200323100-00002
   del Palacio M, 2012, REV MED VIROL, V22, P33, DOI 10.1002/rmv.711
   DeSilva KE, 2001, AIDS, V15, P1281, DOI 10.1097/00002030-200107060-00010
   *EL LILL CO, 2011, PROD INF PROZ FLUOX
   Elliott AJ, 1998, AM J PSYCHIAT, V155, P367
   FERNANDEZ F, 1995, INT J PSYCHIAT MED, V25, P53, DOI 10.2190/16FH-9ECT-Y280-VV45
   *FOR PHARM INC, 2011, PROD INF LEX ESC OX
   *FOR PHARM INC, 2002, PROD INF CEL CIT HYD
   Foster R, 2003, HIV Med, V4, P139, DOI 10.1046/j.1468-1293.2003.00142.x
   *GLAXOSMITHKLINE, 2011, PROD INF PAX PAR HYD
   Gonzalez JS, 2011, JAIDS-J ACQ IMM DEF, V58, P181, DOI [10.1097/QAI.0B013E31822D490A, 10.1097/QAI.0b013e31822d490a]
   Grassi B, 1997, PHARMACOPSYCHIATRY, V30, P70, DOI 10.1055/s-2007-979485
   Greenblatt DJ, 2003, J CLIN PHARMACOL, V43, P414, DOI 10.1177/0091270003251864
   Grinspoon S, 2000, J CLIN ENDOCR METAB, V85, P60, DOI 10.1210/jc.85.1.60
   Gutierrez MM, 2003, CLIN THER, V25, P1200, DOI 10.1016/S0149-2918(03)80076-0
   Harrigan EP, 2004, J CLIN PSYCHOPHARM, V24, P62, DOI 10.1097/01.jcp.0000104913.75206.62
   Hawkins T, 2005, HIV CLIN TRIALS, V6, P187, DOI 10.1310/92VR-FP24-J8GA-B49Q
   Hesse LM, 2006, J CLIN PHARMACOL, V46, P567, DOI 10.1177/0091270006286981
   HRISO E, 1991, AM J PSYCHIAT, V148, P1558
   Kelly DV, 2002, ANN PHARMACOTHER, V36, P827, DOI 10.1345/aph.1A335
   Lera G, 1999, MOVEMENT DISORD, V14, P128, DOI 10.1002/1531-8257(199901)14:1<128::AID-MDS1021>3.0.CO;2-J
   Liu P, 2008, J CLIN PHARMACOL, V48, P73, DOI 10.1177/0091270007309703
   Lodge P, 1998, PALLIATIVE MED, V12, P206, DOI 10.1177/026921639801200310
   Magkos F, 2011, METABOLISM, V60, P749, DOI 10.1016/j.metabol.2010.09.011
   Meyer JM, 1998, BIOL PSYCHIAT, V44, P791, DOI 10.1016/S0006-3223(97)00552-0
   Michaud V, 2012, CLIN PHARMACOL THER, V91, P475, DOI 10.1038/clpt.2011.249
   Nasrallah HA, 2004, J CLIN PSYCHOPHARM, V24, P7, DOI DOI 10.1097/01.JCP.0000142282.62336.E9
   Nejad SH, 2009, PSYCHOSOMATICS, V50, P626, DOI 10.1176/appi.psy.50.6.626
   Nel A, 2011, AIDS CARE, V23, P1360, DOI 10.1080/09540121.2011.565025
   Park J, 2010, J CLIN PHARMACOL, V50, P1180, DOI 10.1177/0091270009359524
   Penzak SR, 2002, J CLIN PSYCHOPHARM, V22, P366, DOI 10.1097/00004714-200208000-00006
   Rabkin JG, 2006, AM J PSYCHIAT, V163, P59, DOI 10.1176/appi.ajp.163.1.59
   Rabkin JG, 2004, J CLIN PSYCHOPHARM, V24, P379, DOI 10.1097/01.jcp.0000132442.35478.3c
   RABKIN JG, 1994, J CLIN PSYCHIAT, V55, P433
   Rabkin JG, 1999, AM J PSYCHIAT, V156, P101, DOI 10.1176/ajp.156.1.101
   RABKIN JG, 1994, AM J PSYCHIAT, V151, P516
   Robertson SM, 2008, JAIDS-J ACQ IMM DEF, V49, P513, DOI 10.1097/QAI.0b013e318183a425
   Schifitto G, 2007, NEUROLOGY, V69, P1314, DOI 10.1212/01.wnl.0000268487.78753.0f
   Schwartz J A, 1999, Depress Anxiety, V9, P70, DOI 10.1002/(SICI)1520-6394(1999)9:2<70::AID-DA4>3.0.CO;2-L
   Singh AN, 1997, J PSYCHOSOM RES, V42, P489, DOI 10.1016/S0022-3999(96)00373-X
   Singh D, 2007, J CLIN PSYCHIAT, V68, P479, DOI 10.4088/JCP.v68n0318
   Spiegel DR, 2010, J NEUROPSYCH CLIN N, V22, P111, DOI 10.1176/appi.neuropsych.22.1.111
   Springer SA, 2009, AIDS CARE, V21, P976, DOI 10.1080/09540120802657555
   Sumari-de Boer IM, 2012, AIDS BEHAV, V16, P1681, DOI 10.1007/s10461-011-0112-y
   TARG EF, 1994, PSYCHOSOMATICS, V35, P132, DOI 10.1016/S0033-3182(94)71786-2
   *TEV PAHRM USA, 2008, PROD INF ORAP PIM
   van der Lee MJ, 2007, ANTIMICROB AGENTS CH, V51, P4098, DOI 10.1128/AAC.01243-06
   Vergara-Rodriguez P, 2009, PHARMACOL THERAPEUT, V124, P269, DOI 10.1016/j.pharmthera.2009.07.004
   Vranceanu AM, 2008, AIDS PATIENT CARE ST, V22, P313, DOI 10.1089/apc.2007.0069
   Wagner GJ, 2000, J CLIN PSYCHIAT, V61, P436, DOI 10.4088/JCP.v61n0608
   Wagner GJ, 2011, ANN BEHAV MED, V42, P352, DOI 10.1007/s12160-011-9295-8
   Watkins CC, 2011, DRUG SAFETY, V34, P623, DOI 10.2165/11592070-000000000-00000
   Zisook S, 1998, J CLIN PSYCHIAT, V59, P217, DOI 10.4088/JCP.v59n0502
   2008, PROD INF GEOD ZIPR H
NR 65
TC 42
Z9 47
U1 1
U2 25
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1060-0280
EI 1542-6270
J9 ANN PHARMACOTHER
JI Ann. Pharmacother.
PD JAN
PY 2013
VL 47
IS 1
BP 75
EP 89
DI 10.1345/aph.1R343
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 225RX
UT WOS:000324981100016
PM 23341158
DA 2025-06-11
ER

PT J
AU Wagner, JA
   Tennen, H
   Mansoor, GA
   Abbott, G
AF Wagner, JA
   Tennen, H
   Mansoor, GA
   Abbott, G
TI History of major depressive disorder and endothelial function in
   postmenopausal women
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE depression; measurement; endothelial function; coronary heart disease;
   women; postmenopausal
ID FLOW-MEDIATED VASODILATION; R PSYCHIATRIC-DISORDERS; STRESSFUL LIFE
   EVENTS; C-REACTIVE PROTEIN; BRACHIAL-ARTERY; CORONARY; HEALTH; SYMPTOMS;
   VALIDITY; DISEASE
AB Objective: To determine whether history of depression is associated with endothelium-dependent flow-mediated dilation (FMD) in postmenopausal women. Methods: Thirty-nine postmenopausal women with no known or suspected cardiovascular disease participated. Nineteen had a positive lifetime history of major depressive disorder, and 20 were never depressed. None were currently depressed, and all had been free of major depressive disorder and antidepressant medications for >= 1 year. History of depression was assessed with the Structured Clinical Interview for DSM-IV, enhanced by a modified version of the timeline follow-back method. Current depressive symptoms were measured with the Center for Epidemiological Studies Depression scale (CES-D). Brachial artery FMD was measured with ultrasound and calculated as percent dilation from baseline. Results: After controlling for current subclinical depressive symptoms, ethnicity, hormone replacement therapy, and presence of the metabolic syndrome, previously depressed women showed significantly and clinically meaningful lower FMD than never depressed women. Controlling the same covariates, there was a dose-response relationship between number of depressive episodes and FMD. Examination of FMD means showed a significant negative correlation between number of depressive episodes and FMD. Conclusion: In postmenopausal women, depression continues to show a negative relationship to endothelial functioning even after years of remission. This relationship is not accounted for by residual depressive symptoms. Implications pertain to exclusion of previously depressed persons from control groups in research exploring the relationship between depression and cardiovascular disease. Key words: depression, measurement, endothelial function, coronary heart disease, women, postmenopausal.
C1 Univ Connecticut, Ctr Hlth, Dept Behav Sci & Community Hlth MC3910, Farmington, CT 06410 USA.
   Univ Connecticut, Ctr Hlth, Dept Community Hlth, Farmington, CT 06410 USA.
   Univ Connecticut, Ctr Hlth, Dept Med, Sect Hypertens, Farmington, CT 06410 USA.
C3 University of Connecticut; University of Connecticut; University of
   Connecticut
RP Univ Connecticut, Ctr Hlth, Dept Behav Sci & Community Hlth MC3910, 263 Farmington Ave, Farmington, CT 06410 USA.
EM juwagner@uchc.edu
CR Agatisa PIK, 2005, ARCH INTERN MED, V165, P1229, DOI 10.1001/archinte.165.11.1229
   ANDRESEN EM, 1994, AM J PREV MED, V10, P77, DOI 10.1016/S0749-3797(18)30622-6
   [Anonymous], 1993, Alcohol Clin Exp Res, V17, P1130
   [Anonymous], MED SCI SPORTS EXERC
   [Anonymous], 1995, Alcohol Timeline Followback Users' Manual
   Bardone AM, 2000, ADDICT BEHAV, V25, P1, DOI 10.1016/S0306-4603(99)00031-3
   Bijl RV, 2002, SOC PSYCH PSYCH EPID, V37, P372, DOI 10.1007/s00127-002-0566-3
   BLANEY PH, 1986, PSYCHOL BULL, V99, P229, DOI 10.1037/0033-2909.99.2.229
   Bothwell R, 1997, J AFFECT DISORDERS, V43, P207, DOI 10.1016/S0165-0327(97)01431-6
   BOWER GH, 1981, AM PSYCHOL, V36, P129, DOI 10.1037/0003-066X.36.2.129
   Brevetti G, 2003, CIRCULATION, V108, P2093, DOI 10.1161/01.CIR.0000095273.92468.D9
   Broadley AJM, 2002, HEART, V88, P521, DOI 10.1136/heart.88.5.521
   Bromberger JT, 2005, GEN HOSP PSYCHIAT, V27, P200, DOI 10.1016/j.genhosppsych.2005.01.007
   Chan SY, 2003, J AM COLL CARDIOL, V42, P1037, DOI 10.1016/S0735-1097(03)00927-6
   Chrapko WE, 2004, BIOL PSYCHIAT, V56, P129, DOI 10.1016/j.biopsych.2004.03.003
   Corretti MC, 2002, J AM COLL CARDIOL, V39, P257, DOI 10.1016/S0735-1097(01)01746-6
   Costa P., 1992, Revised NEO Personality Inventory (NEOPIR) and NEO FiveFactor Inventory (NEOFFI) professional manual
   Crosby GM, 1996, ADDICT BEHAV, V21, P249, DOI 10.1016/0306-4603(96)00055-X
   Danner M, 2003, PSYCHOSOM MED, V65, P347, DOI 10.1097/01.PSY.0000041542.29808.01
   Esen AM, 2004, CIRC J, V68, P1123, DOI 10.1253/circj.68.1123
   FAWCETT J, 1994, BRIT J PSYCHIAT, V165, P37, DOI 10.1192/S0007125000293276
   First M.B., 2016, Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version
   FLEISS JL, 1973, EDUC PSYCHOL MEAS, V33, P613, DOI 10.1177/001316447303300309
   Ford DE, 2004, ARCH INTERN MED, V164, P1010, DOI 10.1001/archinte.164.9.1010
   Gaenzer H, 2001, J AM COLL CARDIOL, V38, P1313, DOI 10.1016/S0735-1097(01)01575-3
   Gokce N, 2003, J AM COLL CARDIOL, V41, P1769, DOI 10.1016/S0735-1097(03)00333-4
   Harris KF, 2003, PSYCHOSOM MED, V65, P402, DOI 10.1097/01.PSY.0000035720.08842.9F
   Hersh D, 1999, J CONSULT CLIN PSYCH, V67, P37, DOI 10.1037/0022-006X.67.1.37
   Jones DJ, 2003, ARCH GEN PSYCHIAT, V60, P153, DOI 10.1001/archpsyc.60.2.153
   Kendler KS, 2000, AM J PSYCHIAT, V157, P1243, DOI 10.1176/appi.ajp.157.8.1243
   Kendler KS, 2001, AM J PSYCHIAT, V158, P587, DOI 10.1176/appi.ajp.158.4.587
   Kennedy N, 2004, J AFFECT DISORDERS, V80, P135, DOI 10.1016/S0165-0327(03)00054-5
   KESSLER RC, 1994, ARCH GEN PSYCHIAT, V51, P8
   Lespérance F, 2004, AM J PSYCHIAT, V161, P271, DOI 10.1176/appi.ajp.161.2.271
   LESPERANCE F, 1999, PSYCHOSOM MED, V58, P99
   Lett HS, 2004, PSYCHOSOM MED, V66, P305, DOI 10.1097/01.psy.0000126207.43307.c0
   Licinio J, 1999, MOL PSYCHIATR, V4, P317, DOI 10.1038/sj.mp.4000586
   Loehr LR, 2004, AM HEART J, V148, P606, DOI 10.1016/j.ahj.2004.04.032
   MEIHLAN E, 1999, HLTH DIS WOMEN BIOL, P155
   Midanik LT, 1998, J STUD ALCOHOL, V59, P681, DOI 10.15288/jsa.1998.59.681
   Mittal VA, 2011, PSYCHIAT RES, V189, P158, DOI 10.1016/j.psychres.2011.06.006
   National Institutes of Health,, 2001, NIH PUBL
   Penninx BWJH, 2001, ARCH GEN PSYCHIAT, V58, P221, DOI 10.1001/archpsyc.58.3.221
   Piché MT, 2004, DIABETES, V53, pA185
   POST RM, 1992, AM J PSYCHIAT, V149, P999
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Rajagopalan S, 2001, AM J CARDIOL, V88, P196, DOI 10.1016/S0002-9149(01)01623-X
   Rossi R, 2005, DIABETES CARE, V28, P702, DOI 10.2337/diacare.28.3.702
   Rothermundt M, 2001, J AFFECT DISORDERS, V63, P93, DOI 10.1016/S0165-0327(00)00157-9
   Rowan PJ, 2005, ANN EPIDEMIOL, V15, P316, DOI 10.1016/j.annepidem.2004.08.006
   Scandell DJ, 2000, PERS INDIV DIFFER, V29, P1153, DOI 10.1016/S0191-8869(99)00262-7
   Segal ZV, 1996, PSYCHOL MED, V26, P371, DOI 10.1017/S0033291700034760
   Sheline YI, 1999, J NEUROSCI, V19, P5034
   SKRE I, 1991, ACTA PSYCHIAT SCAND, V84, P167, DOI 10.1111/j.1600-0447.1991.tb03123.x
   Sobell L.C., Alcohol Timeline Followback (TLFB)
   Solomon DA, 2000, AM J PSYCHIAT, V157, P229, DOI 10.1176/appi.ajp.157.2.229
   Stephens RS, 2002, ADDICTION, V97, P109, DOI 10.1046/j.1360-0443.97.s01.6.x
   Strike PC, 2004, PROG CARDIOVASC DIS, V46, P337, DOI 10.1016/j.pcad.2003.09.001
   Tabachnick B. G., 2019, Using Multivariate Statistics, V7th, DOI DOI 10.1037/022267
   Tokar DM, 1999, MEAS EVAL COUNS DEV, V32, P14, DOI 10.1080/07481756.1999.12068967
   Tuglu C, 2003, PSYCHOPHARMACOLOGY, V170, P429, DOI 10.1007/s00213-003-1566-z
   Vinson DC, 2003, J STUD ALCOHOL, V64, P733, DOI 10.15288/jsa.2003.64.733
   von Känel R, 2001, PSYCHOSOM MED, V63, P531, DOI 10.1097/00006842-200107000-00003
   Wassertheil-Smoller S, 2004, ARCH INTERN MED, V164, P289, DOI 10.1001/archinte.164.3.289
   Weinstock J, 2004, PSYCHOL ASSESSMENT, V16, P72, DOI 10.1037/1040-3590.16.1.72
   WEISSMAN MM, 1977, AM J EPIDEMIOL, V106, P203, DOI 10.1093/oxfordjournals.aje.a112455
   WENGER N, 1997, BMJ-BRIT MED J, V80, pH66
   WENGER NK, 1993, NEW ENGL J MED, V329, P247, DOI 10.1056/NEJM199307223290406
NR 68
TC 43
Z9 53
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JAN-FEB
PY 2006
VL 68
IS 1
BP 80
EP 86
DI 10.1097/01.psy.0000195868.68122.9e
PG 7
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 006ZL
UT WOS:000234936500012
PM 16449415
DA 2025-06-11
ER

PT J
AU Bengtsson, I
   Lissner, L
   Ljung, T
   Rosengren, A
   Thelle, D
   Währborg, P
AF Bengtsson, Inger
   Lissner, Lauren
   Ljung, Thomas
   Rosengren, Annika
   Thelle, Dag
   Wahrborg, Peter
TI The cortisol awakening response and the metabolic syndrome in a
   population-based sample of middle-aged men and women
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; ABDOMINAL OBESITY; SALIVA CORTISOL;
   SEX-DIFFERENCES; STRESS; WAKING; DEPRESSION; SECRETION; GENDER;
   INDIVIDUALS
AB The objective was to explore the relationship between the cortisol awakening response (CAR) and the metabolic syndrome (MetS) as defined by the National Cholesterol Education Program criteria. The final study sample consisted of 91 women (14 with MetS) and 84 men (15 with MetS), aged 45 to 70 years, from a general population sample. The only exclusion criteria were no consent, pregnancy, or insufficient cortisol testing. On the day of measurement (weekday), salivary cortisol was sampled at awakening and 15 minutes after awakening. Relative CAR (CAR%) and the MetS were the main variables studied. Results showed that, in women with the MetS, cortisol at awakening was significantly lower (mean, 8.92 vs 12.33 nmol/L; P = .05) and the CAR was significantly higher (91.4% vs 36.5%, P < .001) than in women without the syndrome. Significant difference in the relative CAR was also present between men and women with MetS (38.5% and 91.4%, respectively; P = .02). No difference was seen in the awakening response comparing men with and without the MetS. In a regression model, the response to awakening was dependent on the MetS in women (F-1,F-89 = 13.19, P < .001); but the model was not significant in men. Furthermore, the awakening response was associated with more depressive symptoms in women (F-1,F-80 = 8.12, P = .01) and with weekday/weekend cortisol sampling in men (F-1,F-82 = 4.63, P = .03). The association between the relative CAR and the MetS remained significant but somewhat attenuated after adjusting for depressive symptoms (P = .01). Results indicate a sex difference in the CAR% in the presence of the MetS independent of depressive symptoms, a known correlate of the MetS. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Bengtsson, Inger] Univ Gothenburg, Dept Mol & Clin Med, Sahlgrenska Sch Publ Hlth & Community Med, Sahlgrenska Acad,Publ Hlth Epidemiol Unit EPI, Gothenburg, Sweden.
   Univ Gavle, Gavle, Sweden.
   Sahlgrens Univ Hosp, Dept Med, Gothenburg, Sweden.
   Univ Oslo, Inst Basic Med Sci, Dept Biostat, Oslo, Norway.
C3 University of Gothenburg; University of Gavle; Sahlgrenska University
   Hospital; University of Oslo
RP Bengtsson, I (corresponding author), Univ Gothenburg, Dept Mol & Clin Med, Sahlgrenska Sch Publ Hlth & Community Med, Sahlgrenska Acad,Publ Hlth Epidemiol Unit EPI, Gothenburg, Sweden.
EM ibengtsson@telia.com
RI Thelle, Dag/ABD-1867-2020
OI Thelle, Dag Steinar/0000-0002-4417-5967
FU Institute of Stress Medicine in Goteborg; Goteborg Medical Society;
   Local Research and Development Council of Goteborg and Southern
   Bohuslan; Swedish Heart and Lung Foundation; Swedish Council on Working
   Life and Social Research
FX This study was financially supported by grants from the Institute of
   Stress Medicine in Goteborg, the Goteborg Medical Society, the Local
   Research and Development Council of Goteborg and Southern Bohuslan, the
   Swedish Heart and Lung Foundation, and the Swedish Council on Working
   Life and Social Research.
CR Backhaus J, 2004, PSYCHONEUROENDOCRINO, V29, P1184, DOI 10.1016/j.psyneuen.2004.01.010
   Berg CM, 2008, AM J CLIN NUTR, V88, P289
   Bhagwagar Z, 2005, PSYCHOPHARMACOLOGY, V182, P54, DOI 10.1007/s00213-005-0062-z
   Chida Y, 2009, BIOL PSYCHOL, V80, P265, DOI 10.1016/j.biopsycho.2008.10.004
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Clow A, 2004, STRESS, V7, P29, DOI 10.1080/10253890410001667205
   Dockray S, 2008, PSYCHONEUROENDOCRINO, V33, P77, DOI 10.1016/j.psyneuen.2007.10.001
   Duclos M, 2005, OBES RES, V13, P1157, DOI 10.1038/oby.2005.137
   Edwards S, 2001, LIFE SCI, V68, P2093, DOI 10.1016/S0024-3205(01)00996-1
   Eek FC, 2006, SCAND J WORK ENV HEA, P15
   Eller NH, 2005, PSYCHONEUROENDOCRINO, V30, P715, DOI 10.1016/j.psyneuen.2005.01.005
   Epel ES, 2000, PSYCHOSOM MED, V62, P623, DOI 10.1097/00006842-200009000-00005
   Federenko I, 2004, PSYCHONEUROENDOCRINO, V29, P174, DOI 10.1016/S0306-4530(03)00021-0
   Fries E, 2005, PSYCHONEUROENDOCRINO, V30, P1010, DOI 10.1016/j.psyneuen.2005.04.006
   Fries E, 2009, INT J PSYCHOPHYSIOL, V72, P67, DOI 10.1016/j.ijpsycho.2008.03.014
   Gold PW, 2002, MOL PSYCHIATR, V7, P254, DOI 10.1038/sj.mp.4001032
   Heim C, 2000, PSYCHONEUROENDOCRINO, V25, P1, DOI 10.1016/S0306-4530(99)00035-9
   Hellhammer DH, 2009, PSYCHONEUROENDOCRINO, V34, P163, DOI 10.1016/j.psyneuen.2008.10.026
   Hellhammer J, 2007, PSYCHONEUROENDOCRINO, V32, P80, DOI 10.1016/j.psyneuen.2006.10.005
   Hu G, 2004, ARCH INTERN MED, V164, P1066, DOI 10.1001/archinte.164.10.1066
   Kajantie E, 2006, PSYCHONEUROENDOCRINO, V31, P151, DOI 10.1016/j.psyneuen.2005.07.002
   Kudielka BM, 2003, PSYCHONEUROENDOCRINO, V28, P35, DOI 10.1016/S0306-4530(02)00008-2
   Kudielka BM, 2005, BIOL PSYCHOL, V69, P113, DOI 10.1016/j.biopsycho.2004.11.009
   Kunz-Ebrecht SR, 2004, PSYCHONEUROENDOCRINO, V29, P516, DOI 10.1016/S0306-4530(03)00072-6
   Lasikiewicz N, 2008, PSYCHONEUROENDOCRINO, V33, P143, DOI 10.1016/j.psyneuen.2007.10.013
   Lind K, 2007, DEMENT GERIATR COGN, V24, P389, DOI 10.1159/000109938
   Ljung T, 2000, OBES RES, V8, P487, DOI 10.1038/oby.2000.61
   MARIN P, 1992, METABOLISM, V41, P882, DOI 10.1016/0026-0495(92)90171-6
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   Otte C, 2005, PSYCHONEUROENDOCRINO, V30, P80, DOI 10.1016/j.psyneuen.2004.06.002
   Pruessner M, 2003, PSYCHOSOM MED, V65, P92, DOI 10.1097/01.PSY.0000040950.22044.10
   Rosmond R, 2003, J INTERN MED, V254, P386, DOI 10.1046/j.1365-2796.2003.01205.x
   Schlotz W, 2004, PSYCHOSOM MED, V66, P207, DOI 10.1097/01.psy.0000116715.78238.56
   Schulz P, 1998, STRESS MEDICINE, V14, P91, DOI 10.1002/(SICI)1099-1700(199804)14:2<91::AID-SMI765>3.0.CO;2-S
   Steptoe A, 2004, INT J OBESITY, V28, P1168, DOI 10.1038/sj.ijo.0802715
   Stetler C, 2005, J ABNORM PSYCHOL, V114, P697, DOI 10.1037/0021-843X.114.4.697
   Stroud LR, 2002, BIOL PSYCHIAT, V52, P318, DOI 10.1016/S0006-3223(02)01333-1
   Therrien F, 2007, OBESITY, V15, P377, DOI 10.1038/oby.2007.509
   Vicennati V, 2000, J CLIN ENDOCR METAB, V85, P4093, DOI 10.1210/jc.85.11.4093
   Wallerius S, 2003, J ENDOCRINOL INVEST, V26, P616, DOI 10.1007/BF03347017
   Weekes NY, 2008, PSYCHONEUROENDOCRINO, V33, P766, DOI 10.1016/j.psyneuen.2008.03.003
   Wirtz PH, 2007, PSYCHONEUROENDOCRINO, V32, P430, DOI 10.1016/j.psyneuen.2007.02.006
   World Health Organization, 2000, WHO TECHN REP SER, V894
   Wright CE, 2005, PSYCHONEUROENDOCRINO, V30, P582, DOI 10.1016/j.psyneuen.2005.01.007
   ZUNG WWK, 1965, ARCH GEN PSYCHIAT, V12, P63, DOI 10.1001/archpsyc.1965.01720310065008
NR 45
TC 16
Z9 16
U1 0
U2 11
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUL
PY 2010
VL 59
IS 7
BP 1012
EP 1019
DI 10.1016/j.metabol.2009.10.024
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA 611WH
UT WOS:000278854400012
PM 20045155
DA 2025-06-11
ER

PT J
AU Tsai, SF
   Hsu, PL
   Chen, YW
   Hossain, MS
   Chen, PC
   Tzeng, SF
   Chen, PS
   Kuo, YM
AF Tsai, Sheng-Feng
   Hsu, Pei-Ling
   Chen, Yun-Wen
   Hossain, Mohammad Shahadat
   Chen, Pei-Chun
   Tzeng, Shun-Fen
   Chen, Po-See
   Kuo, Yu-Min
TI High-fat diet induces depression-like phenotype via astrocyte-mediated
   hyperactivation of ventral hippocampal glutamatergic afferents to the
   nucleus accumbens
SO MOLECULAR PSYCHIATRY
LA English
DT Article
ID PROTEIN (GFAP)-IMMUNOREACTIVE ASTROCYTES; INDUCED UP-REGULATION;
   OPEN-LABEL TRIAL; METABOLIC SYNDROME; SOCIAL DEFEAT; DOUBLE-BLIND;
   DOPAMINE NEURONS; REWARD CIRCUIT; RAT-BRAIN; RILUZOLE
AB Comorbidity exists between metabolic disorders and depressive syndrome with unclear mechanisms. To characterize the causal relationship, we adopted a 12-week high-fat diet (HFD) to induce metabolic disorder and depressive phenotypes in mice. Initially, we identified an enhanced glutamatergic input in the nucleus accumbens of HFD mice. Retrograde tracing and chemogenetic inhibition showed that the hyperactive ventral hippocampal glutamatergic afferents to the nucleus accumbens determined the exhibition of depression-like behavior in HFD mice. Using lentiviral knockdown and overexpression approaches, we proved that HFD-induced downregulation of glial glutamate transporters, GLAST and GLT-1, contributed to the observed circuit maladaptations and subsequent depression-like behaviors. Finally, we identified a potential therapeutic agent, riluzole, which could mitigate the HFD-induced behavioral deficits by normalizing the expressions of GLAST and GLT-1 and ventral hippocampal glutamatergic afferents to the nucleus accumbens. Overall, astrocyte-mediated disturbance in glutamatergic transmission underlies the metabolic disorder-related depressive syndrome and represents a therapeutic target for this subtype of depressive mood disorders.
C1 [Tsai, Sheng-Feng; Hsu, Pei-Ling; Chen, Yun-Wen; Chen, Pei-Chun; Tzeng, Shun-Fen; Kuo, Yu-Min] Natl Cheng Kung Univ, Coll Med, Inst Basic Med Sci, Tainan 70101, Taiwan.
   [Tsai, Sheng-Feng; Hossain, Mohammad Shahadat; Kuo, Yu-Min] Natl Cheng Kung Univ, Coll Med, Dept Cell Biol & Anat, Tainan 70101, Taiwan.
   [Hsu, Pei-Ling; Chen, Pei-Chun] Natl Cheng Kung Univ, Coll Med, Dept Physiol, Tainan 70101, Taiwan.
   [Hsu, Pei-Ling] Kaohsiung Med Univ, Coll Med, Sch Med, Dept Anat, Kaohsiung 80708, Taiwan.
   [Chen, Yun-Wen] Natl Cheng Kung Univ, Coll Med, Dept Pharmacol, Tainan 70101, Taiwan.
   [Hossain, Mohammad Shahadat] Natl Cheng Kung Univ, Acad Sinica, Taiwan Int Grad Program, Interdisciplinary Neurosci, Tainan 70101, Taiwan.
   [Tzeng, Shun-Fen] Natl Cheng Kung Univ, Coll Biosci & Biotechnol, Dept Life Sci, Tainan 70101, Taiwan.
   [Chen, Po-See] Natl Cheng Kung Univ, Coll Med, Dept Psychiat, Tainan 70101, Taiwan.
   [Chen, Po-See] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Addict Res Ctr, Tainan 70403, Taiwan.
C3 National Cheng Kung University; National Cheng Kung University; National
   Cheng Kung University; Kaohsiung Medical University; National Cheng Kung
   University; Academia Sinica - Taiwan; National Cheng Kung University;
   National Cheng Kung University; National Cheng Kung University; National
   Cheng Kung University; National Cheng Kung University Hospital
RP Kuo, YM (corresponding author), Natl Cheng Kung Univ, Coll Med, Inst Basic Med Sci, Tainan 70101, Taiwan.; Kuo, YM (corresponding author), Natl Cheng Kung Univ, Coll Med, Dept Cell Biol & Anat, Tainan 70101, Taiwan.
EM kuoym@mail.ncku.edu.tw
RI Hsu, Pei-Ling/HPH-5474-2023; Chen, Po/AAA-6492-2021; Sheng Feng,
   Tsai/HZM-0540-2023; Chen, Pei-Chun/K-8439-2019; Kuo, Yu-Min/A-9050-2013
OI Tsai, Sheng-Feng/0000-0001-5800-4280; Hsu, Pei-Ling/0000-0003-2035-8344;
   Kuo, Yu-Min/0000-0003-4867-2482; Hossain, Mohammad
   Shahadat/0000-0003-2660-8527
FU Ministry of Science and Technology, Taiwan [106-2320-B-006-049,
   107-2320-B-006-013, 108-2320-B-006-001, 109-2320-B-006-043-MY3,
   110-2320-B-006-021, 107-2811-B-006-532, 108-2811-B-006-533,
   109-2811-B-006-520, 110-2811-B-006-546]; Laboratory Animal Center,
   College of Medicine, National Cheng Kung University, Taiwan; Bioimaging
   Core Facility of the National Core Facility for Biopharmaceuticals,
   Ministry of Science and Technology, Taiwan; National Laboratory Animal
   Center, NARLabs, Taiwan; National RNAi Core Facility at Academia Sinica,
   Taiwan
FX We are grateful for the support and services from 1) Laboratory Animal
   Center, College of Medicine, National Cheng Kung University, Taiwan, 2)
   Bioimaging Core Facility of the National Core Facility for
   Biopharmaceuticals, Ministry of Science and Technology, Taiwan, 3)
   National Laboratory Animal Center, NARLabs, Taiwan, 4) National RNAi
   Core Facility at Academia Sinica, Taiwan. This project was funded by
   Ministry of Science and Technology, Taiwan (Grant #: 106-2320-B-006-049,
   107-2320-B-006-013, 108-2320-B-006-001, 109-2320-B-006-043-MY3,
   110-2320-B-006-021, 107-2811-B-006-532, 108-2811-B-006-533,
   109-2811-B-006-520, and 110-2811-B-006-546).
CR Abdallah CG, 2018, PHARMACOL THERAPEUT, V190, P148, DOI 10.1016/j.pharmthera.2018.05.010
   Abildgaard A, 2011, PSYCHONEUROENDOCRINO, V36, P623, DOI 10.1016/j.psyneuen.2010.09.004
   Alshammari TK, 2021, PROG NEURO-PSYCHOPH, V105, DOI 10.1016/j.pnpbp.2020.110120
   Asztely F, 1997, NEURON, V18, P281, DOI 10.1016/S0896-6273(00)80268-8
   Bagot RC, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8062
   Bechtholt-Gompf AJ, 2010, NEUROPSYCHOPHARMACOL, V35, P2049, DOI 10.1038/npp.2010.74
   Berton O, 2006, SCIENCE, V311, P864, DOI 10.1126/science.1120972
   Britt JP, 2012, NEURON, V76, P790, DOI 10.1016/j.neuron.2012.09.040
   Cao JL, 2010, J NEUROSCI, V30, P16453, DOI 10.1523/JNEUROSCI.3177-10.2010
   Carbone M, 2012, NEUROCHEM INT, V60, P31, DOI 10.1016/j.neuint.2011.10.017
   Chaudhury D, 2013, NATURE, V493, P532, DOI 10.1038/nature11713
   Chiu YJ, 2021, BIOMED PHARMACOTHER, V141, DOI 10.1016/j.biopha.2021.111848
   Choudary PV, 2005, P NATL ACAD SCI USA, V102, P15653, DOI 10.1073/pnas.0507901102
   Covington HE, 2010, J NEUROSCI, V30, P16082, DOI 10.1523/JNEUROSCI.1731-10.2010
   Czerniawski J, 2011, J NEUROSCI, V31, P11200, DOI 10.1523/JNEUROSCI.2211-11.2011
   Danbolt NC, 2001, PROG NEUROBIOL, V65, P1, DOI 10.1016/S0301-0082(00)00067-8
   Delgado PL, 2000, J CLIN PSYCHIAT, V61, P7
   Demakakos P, 2014, PSYCHOSOM MED, V76, P555, DOI 10.1097/PSY.0000000000000082
   Duman RS, 2016, NAT MED, V22, P238, DOI 10.1038/nm.4050
   Fagiolini A, 2008, J CLIN PSYCHIAT, V69, P678, DOI 10.4088/JCP.v69n0423c
   Faith MS, 2002, J PSYCHOSOM RES, V53, P935, DOI 10.1016/S0022-3999(02)00308-2
   Fanelli G, 2022, EUR NEUROPSYCHOPHARM, V60, P4, DOI 10.1016/j.euroneuro.2022.04.011
   Ferguson SM, 2011, NAT NEUROSCI, V14, P22, DOI 10.1038/nn.2703
   Floresco SB, 2001, J NEUROSCI, V21, P4915, DOI 10.1523/JNEUROSCI.21-13-04915.2001
   Francis TC, 2015, BIOL PSYCHIAT, V77, P212, DOI 10.1016/j.biopsych.2014.07.021
   Friedman AK, 2014, SCIENCE, V344, P313, DOI 10.1126/science.1249240
   Frizzo MED, 2004, CELL MOL NEUROBIOL, V24, P123, DOI 10.1023/B:CEMN.0000012717.37839.07
   Fumagalli E, 2008, EUR J PHARMACOL, V578, P171, DOI 10.1016/j.ejphar.2007.10.023
   Ghayour MB, 2017, EUR J TRAUMA EMERG S, V43, P691, DOI 10.1007/s00068-016-0691-4
   Gold SM, 2020, NAT REV DIS PRIMERS, V6, DOI 10.1038/s41572-020-0200-2
   Golden SH, 2008, JAMA-J AM MED ASSOC, V299, P2751, DOI 10.1001/jama.299.23.2751
   American Heart Association, 2005, Cardiol Rev, V13, P322
   HAJOS F, 1989, EXP BRAIN RES, V78, P164
   Haroon E, 2017, NEUROPSYCHOPHARMACOL, V42, P193, DOI 10.1038/npp.2016.199
   Holgate S T, 1989, Prog Clin Biol Res, V297, P103
   John CS, 2015, NEUROPSYCHOPHARMACOL, V40, P1700, DOI 10.1038/npp.2015.16
   John CS, 2012, NEUROPSYCHOPHARMACOL, V37, P2467, DOI 10.1038/npp.2012.105
   Jones JR, 2018, CELL REP, V25, P947, DOI 10.1016/j.celrep.2018.09.083
   KALMAN M, 1989, EXP BRAIN RES, V78, P147
   Karki P, 2014, GLIA, V62, P1270, DOI 10.1002/glia.22679
   Karki P, 2013, J BIOL CHEM, V288, P28975, DOI 10.1074/jbc.M113.483826
   Khakh BS, 2019, ANNU REV NEUROSCI, V42, P187, DOI 10.1146/annurev-neuro-070918-050443
   Khakh BS, 2015, NAT NEUROSCI, V18, P942, DOI 10.1038/nn.4043
   Klavir O, 2017, NAT NEUROSCI, V20, P836, DOI 10.1038/nn.4523
   Knowland D, 2018, PHARMACOL BIOCHEM BE, V174, P42, DOI 10.1016/j.pbb.2017.12.010
   Kokras N, 2012, NEUROPHARMACOLOGY, V62, P436, DOI 10.1016/j.neuropharm.2011.08.025
   Koo JW, 2016, BIOL PSYCHIAT, V80, P469, DOI 10.1016/j.biopsych.2015.12.009
   Krishnan V, 2008, NATURE, V455, P894, DOI 10.1038/nature07455
   Krishnan V, 2007, CELL, V131, P391, DOI 10.1016/j.cell.2007.09.018
   Lam YY, 2021, BIOMED PHARMACOTHER, V140, DOI 10.1016/j.biopha.2021.111734
   Lee ESY, 2009, J NEUROCHEM, V110, P530, DOI 10.1111/j.1471-4159.2009.06105.x
   Lee E, 2013, NEUROTOX RES, V23, P124, DOI 10.1007/s12640-012-9347-2
   Lee E, 2012, J BIOL CHEM, V287, P26817, DOI 10.1074/jbc.M112.341867
   Lin CCJ, 2017, NAT NEUROSCI, V20, P396, DOI 10.1038/nn.4493
   Liu AYC, 2011, J BIOL CHEM, V286, P2785, DOI 10.1074/jbc.M110.158220
   Lobo MK, 2013, J NEUROSCI, V33, P18381, DOI 10.1523/JNEUROSCI.1875-13.2013
   Mathew SJ, 2017, NEUROPSYCHOPHARMACOL, V42, P2567, DOI 10.1038/npp.2017.106
   McIntyre Roger S, 2007, Ann Clin Psychiatry, V19, P257, DOI 10.1080/10401230701653377
   McIntyre RS, 2009, CURR DIABETES REP, V9, P51, DOI 10.1007/s11892-009-0010-0
   Medina A, 2013, J PSYCHIATR RES, V47, P1150, DOI 10.1016/j.jpsychires.2013.04.007
   Moulton CD, 2015, LANCET DIABETES ENDO, V3, P461, DOI 10.1016/S2213-8587(15)00134-5
   Murrough JW, 2017, NAT REV DRUG DISCOV, V16, P472, DOI 10.1038/nrd.2017.16
   Nestler EJ, 2006, BIOL PSYCHIAT, V59, P1151, DOI 10.1016/j.biopsych.2005.09.018
   Pajarillo E, 2018, NEUROTOXICOLOGY, V65, P280, DOI 10.1016/j.neuro.2017.11.008
   Park LT, 2017, J CLIN PSYCHOPHARM, V37, P355, DOI 10.1097/JCP.0000000000000693
   Parker G, 2010, INT REV PSYCHIATR, V22, P429, DOI 10.3109/09540261.2010.492391
   Pereira AC, 2017, MOL PSYCHIATR, V22, P296, DOI 10.1038/mp.2016.33
   Perez SM, 2018, J NEUROSCI, V38, P10607, DOI 10.1523/JNEUROSCI.2629-16.2018
   Pi GL, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-019-13919-3
   Purohit K, 2018, ALCOHOL CLIN EXP RES, V42, P879, DOI 10.1111/acer.13626
   Rada P, 2003, NEUROSCIENCE, V119, P557, DOI 10.1016/S0306-4522(03)00162-3
   Razzoli M, 2011, BEHAV BRAIN RES, V218, P253, DOI 10.1016/j.bbr.2010.11.050
   Reardon S, 2019, NATURE, V571, P456, DOI 10.1038/d41586-019-02133-2
   Rothstein JD, 1996, NEURON, V16, P675, DOI 10.1016/S0896-6273(00)80086-0
   Sakurai H, 2019, J AFFECT DISORDERS, V258, P102, DOI 10.1016/j.jad.2019.06.065
   Salardini E, 2016, J PSYCHIATR RES, V75, P24, DOI 10.1016/j.jpsychires.2016.01.003
   Sámano C, 2012, NEUROSCIENCE, V222, P356, DOI 10.1016/j.neuroscience.2012.06.064
   Sanacora G, 2008, NAT REV DRUG DISCOV, V7, P426, DOI 10.1038/nrd2462
   Sanacora G, 2013, BIOL PSYCHIAT, V73, P1172, DOI 10.1016/j.biopsych.2013.03.032
   Sanacora G, 2012, NEUROPHARMACOLOGY, V62, P63, DOI 10.1016/j.neuropharm.2011.07.036
   Sharma S, 2013, INT J OBESITY, V37, P382, DOI 10.1038/ijo.2012.48
   Sofroniew MV, 2010, ACTA NEUROPATHOL, V119, P7, DOI 10.1007/s00401-009-0619-8
   Tsai SF, 2018, BRAIN RES, V1700, P66, DOI 10.1016/j.brainres.2018.07.017
   Tsai SF, 2018, NEUROENDOCRINOLOGY, V107, P147, DOI 10.1159/000491018
   Tzingounis AV, 2007, NAT REV NEUROSCI, V8, P935, DOI 10.1038/nrn2274
   Vagena E, 2019, TRANSL PSYCHIAT, V9, DOI 10.1038/s41398-019-0470-1
   Veruki ML, 2006, NAT NEUROSCI, V9, P1388, DOI 10.1038/nn1793
   Yang JL, 2016, SCI REP-UK, V6, DOI 10.1038/srep35239
   Zarate CA, 2005, BIOL PSYCHIAT, V57, P430, DOI 10.1016/j.biopsych.2004.11.023
   Zarate CA, 2004, AM J PSYCHIAT, V161, P171, DOI 10.1176/appi.ajp.161.1.171
   Zhou LY, 2019, J NEUROCHEM, V150, P6, DOI 10.1111/jnc.14686
   Zink M, 2010, NEUROPHARMACOLOGY, V58, P465, DOI 10.1016/j.neuropharm.2009.09.005
NR 92
TC 28
Z9 28
U1 2
U2 28
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD NOV
PY 2022
VL 27
IS 11
BP 4372
EP 4384
DI 10.1038/s41380-022-01787-1
EA SEP 2022
PG 13
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA 9B2MM
UT WOS:000862189700001
PM 36180573
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Ouanes, S
   Hashem, LA
   Makki, I
   Khan, F
   Mahgoub, O
   Wafer, A
   Dulaimy, O
   Amro, R
   Ghuloum, S
AF Ouanes, Sami
   Hashem, Lien Abou
   Makki, Ibrahim
   Khan, Faisal
   Mahgoub, Omer
   Wafer, Ahmed
   Dulaimy, Omer
   Amro, Raed
   Ghuloum, Suhaila
TI Mortality in Qatari individuals with mental illness: a retrospective
   cohort study
SO ANNALS OF GENERAL PSYCHIATRY
LA English
DT Article
DE Mortality; Mental illness; Death; Morbidity; Retrospective cohort
ID QUALITY-OF-CARE; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   PSYCHIATRIC-DISORDERS; DEPRESSIVE DISORDER; ANXIETY; PEOPLE; RISK;
   METAANALYSIS; PREVALENCE
AB Introduction There is substantial evidence that people with mental illness have higher mortality rates than the general population. However, most of the studies were from Western countries, and it is not clear whether this finding also applies to Arab countries like Qatar. Objectives We aimed to explore whether mortality in patients with mental illness in Qatar, is different from those without. Methods We conducted a retrospective cohort study, including all Qatari nationals deceased in 2017 and 2018, using the list of registered deaths from Hamad Medical Corporation (HMC) Mortuary. We divided the cohort of deceased people into two groups: with and without mental illness. For each of the groups, we collected the age at death, the reported cause of death as well as sociodemographic and clinical data. Results There were 602 registered deaths in 2017 and 589 deaths in 2018. The prevalence of mental illness was 20.4%. Compared to subjects without mental illness, subjects with mental illness surprisingly had higher age at death (median +/- IQR = 76.5 +/- 22.1 years vs. 62.7 +/- 32.9 years; p < .001). This difference persisted even after we controlled for covariates. Individuals with mental illness were more likely to die of an infection (OR = 1.98[1.44;2.71]), or of chronic respiratory disease (OR = 3.53 [1.66;7.52]) but less likely to die because of accidental (OR = 0.21[0.09;0.49]) or congenital causes (OR = 0.18[0.04;0.77]). Conclusion Contrary to most previous studies, we did not find that mortality was higher in Qatari individuals with mental illness. Sociocultural factors, free and easy-to-access healthcare, and an enhanced role of mental health professionals in detecting medical comorbidities may explain this finding.
C1 [Ouanes, Sami; Hashem, Lien Abou; Makki, Ibrahim; Khan, Faisal; Mahgoub, Omer; Wafer, Ahmed; Dulaimy, Omer; Amro, Raed; Ghuloum, Suhaila] Hamad Med Corp, Dept Psychiat, POB 3050, Doha, Qatar.
C3 Hamad Medical Corporation
RP Ghuloum, S (corresponding author), Hamad Med Corp, Dept Psychiat, POB 3050, Doha, Qatar.
EM sghuloum@hamad.qa
OI Makki, Ibrahim/0000-0001-8460-7616
FU Hamad Medical Corporation
FX We thank Dr. Hassan Hashem Elamin for his contribution to the data
   collection for this research project.
CR Al-Rawi Safa, 2021, Qatar Med J, V2021, P27, DOI 10.5339/qmj.2021.27
   Al-Thani MH, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2015-009514
   Ali S, 2022, J PSYCHIATR RES, V149, P97, DOI 10.1016/j.jpsychires.2022.02.036
   AlMulla A, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0250065
   Aloudah NM, 2021, EXPLOR RES CLIN SOC, V4, DOI 10.1016/j.rcsop.2021.100070
   Alshawwaf Mahmoud, 2021, Qatar Med J, V2021, P32, DOI 10.5339/qmj.2021.32
   Andersson NW, 2016, INT J EPIDEMIOL, V45, P131, DOI 10.1093/ije/dyv333
   Atlantis E, 2013, CHEST, V144, P766, DOI 10.1378/chest.12-1911
   Awadalla M, 2016, INJURY PREV, V22, pA309, DOI 10.1136/injuryprev-2016-042156.868
   Barber S, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00463
   Bener A, 2014, Int J Clin Psychiatry Ment Health, V2, P38, DOI [10.12970/2310-8231.2014.02.01.4, DOI 10.12970/2310-8231.2014.02.01.4]
   Björkenstam E, 2012, BMJ OPEN, V2, DOI 10.1136/bmjopen-2011-000778
   Bo S, 2007, DIABETES RES CLIN PR, V75, P362, DOI 10.1016/j.diabres.2006.06.031
   Byrne P, 2022, IRISH J PSYCHOL MED, DOI 10.1017/ipm.2022.3
   Carroll D, 2009, BIOL PSYCHIAT, V66, P91, DOI 10.1016/j.biopsych.2009.02.020
   Castagnini AC, 2011, SOC PSYCH PSYCH EPID, V46, P1013, DOI 10.1007/s00127-010-0276-1
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   Crump C, 2013, BRIT J PSYCHIAT, V203, P297, DOI 10.1192/bjp.bp.112.123992
   Dickerson F, 2021, PSYCHIAT RES, V298, DOI 10.1016/j.psychres.2021.113755
   Dickerson FB, 2018, LANCET PSYCHIAT, V5, P610, DOI 10.1016/S2215-0366(18)30209-8
   Druss BG, 2002, MED CARE, V40, P129, DOI 10.1097/00005650-200202000-00007
   Emdin CA, 2016, AM J CARDIOL, V118, P511, DOI 10.1016/j.amjcard.2016.05.041
   Engelke R, 2022, FRONT PSYCHIATRY, V13, DOI 10.3389/fpsyt.2022.809071
   Erlangsen A, 2017, LANCET PSYCHIAT, V4, P937, DOI 10.1016/S2215-0366(17)30429-7
   Fernandez de la Cruz L, 2022, NEUROSCI BIOBEHAV R, V136, DOI 10.1016/j.neubiorev.2022.104602
   Fiest KM, 2016, CAN J NEUROL SCI, V43, pS3, DOI 10.1017/cjn.2016.18
   Gfroerer J, 2013, MMWR-MORBID MORTAL W, V62, P81
   Hammoudeh S, 2018, BMC PSYCHIATRY, V18, DOI 10.1186/s12888-018-1662-6
   Howell S, 2019, HEART, V105, P1852, DOI 10.1136/heartjnl-2017-312107
   Karim MA, 2021, BMC PSYCHIATRY, V21, DOI 10.1186/s12888-021-03121-5
   Kiecolt-Glaser JK, 2002, J PSYCHOSOM RES, V53, P873, DOI 10.1016/S0022-3999(02)00309-4
   Kilbourne AM, 2008, J GEN INTERN MED, V23, P1628, DOI 10.1007/s11606-008-0720-z
   Knaak Stephanie, 2017, Healthc Manage Forum, V30, P111, DOI 10.1177/0840470416679413
   Laursen TM, 2007, J CLIN PSYCHIAT, V68, P899, DOI 10.4088/JCP.v68n0612
   Laursen TM, 2016, J AFFECT DISORDERS, V193, P203, DOI 10.1016/j.jad.2015.12.067
   Laursen TM, 2014, ANNU REV CLIN PSYCHO, V10, P425, DOI 10.1146/annurev-clinpsy-032813-153657
   Lê Cook B, 2014, JAMA-J AM MED ASSOC, V311, P172, DOI 10.1001/jama.2013.284985
   Lester David, 2006, Arch Suicide Res, V10, P77, DOI 10.1080/13811110500318489
   Lew B, 2022, BMC PUBLIC HEALTH, V22, DOI 10.1186/s12889-022-13101-3
   Mai Q, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-118
   May M, 2020, BRAIN BEHAV IMMUN-HL, V6, DOI 10.1016/j.bbih.2020.100097
   Meier SM, 2016, BRIT J PSYCHIAT, V209, P216, DOI 10.1192/bjp.bp.115.171975
   Merhej R, 2019, INT J HUM RIGHTS HEA, V12, P285, DOI 10.1108/IJHRH-03-2019-0025
   Ndosi NK, 1997, E AFR MED J, V74, P82
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Plana-Ripoll O, 2019, LANCET, V394, P1827, DOI 10.1016/S0140-6736(19)32316-5
   Planning and Statistics Authority, 2018, Woman and Man in the State of Qatar - A Statistical Portrait
   Pritchard C, 2020, BJPSYCH OPEN, V6, DOI 10.1192/bjo.2020.38
   Pumar MI, 2014, J THORAC DIS, V6, P1615, DOI 10.3978/j.issn.2072-1439.2014.09.28
   Reddy G, 2017, PSYCHIAT ANN, V47, P362, DOI 10.3928/00485713-20170606-01
   Schneider-Thoma J, 2018, LANCET PSYCHIAT, V5, P653, DOI 10.1016/S2215-0366(18)30177-9
   Scott D, 2012, J HEALTHC QUAL, V34, P15, DOI 10.1111/j.1945-1474.2011.00155.x
   Solmi M, 2020, LANCET PSYCHIAT, V7, P52, DOI 10.1016/S2215-0366(19)30414-6
   Song H, 2019, BMJ-BRIT MED J, V367, DOI 10.1136/bmj.l5784
   Suetani S, 2021, SCHIZOPHR RES, V237, P131, DOI 10.1016/j.schres.2021.08.022
   Taipale H, 2018, SCHIZOPHR RES, V197, P274, DOI 10.1016/j.schres.2017.12.010
   Tarlochan F, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19010514
   Torniainen M, 2015, SCHIZOPHRENIA BULL, V41, P656, DOI 10.1093/schbul/sbu164
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vermeulen J, 2017, PSYCHOL MED, V47, P2217, DOI 10.1017/S0033291717000873
   Walker ER, 2015, JAMA PSYCHIAT, V72, P334, DOI 10.1001/jamapsychiatry.2014.2502
   Wang MT, 2017, JAMA PSYCHIAT, V74, P252, DOI 10.1001/jamapsychiatry.2016.3793
   Weiner M, 2011, ANN CLIN PSYCHIATRY, V23, P40
   Yohannes AM, 2014, EUR RESPIR REV, V23, P345, DOI 10.1183/09059180.00007813
   Yoshida K, 2021, BEHAV BRAIN RES, V402, DOI 10.1016/j.bbr.2020.113098
   Zgueb Y, 2014, ENCEPHALE, V40, P416, DOI 10.1016/j.encep.2014.07.007
NR 66
TC 0
Z9 0
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1744-859X
J9 ANN GEN PSYCHIATR
JI Ann. Gen. Psychiatr.
PD APR 18
PY 2024
VL 23
IS 1
AR 14
DI 10.1186/s12991-024-00499-w
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA OE1O8
UT WOS:001205496300002
PM 38637811
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Andreu, Y
   Chiarugi, F
   Colantonio, S
   Giannakakis, G
   Giorgi, D
   Henriquez, P
   Kazantzaki, E
   Manousos, D
   Marias, K
   Matuszewski, BJ
   Pascali, MA
   Pediaditis, M
   Raccichini, G
   Tsiknakis, M
AF Andreu, Yasmina
   Chiarugi, Franco
   Colantonio, Sara
   Giannakakis, Giorgos
   Giorgi, Daniela
   Henriquez, Pedro
   Kazantzaki, Eleni
   Manousos, Dimitris
   Marias, Kostas
   Matuszewski, Bogdan J.
   Pascali, Maria Antonietta
   Pediaditis, Matthew
   Raccichini, Giovanni
   Tsiknakis, Manolis
TI Wize Mirror - a smart, multisensory cardio-metabolic risk monitoring
   system
SO COMPUTER VISION AND IMAGE UNDERSTANDING
LA English
DT Article
DE Unobtrusive health monitoring; 3D face detection; Tracking and
   reconstruction; 3D morphometric analysis; Psycho-somatic status
   recognition; Multimodal data integration
ID HEAD POSE ESTIMATION; FACE; ANXIETY; RECOGNITION; STRESS; ADULTS; SHAPE
AB In the recent years personal health monitoring systems have been gaining popularity, both as a result of the pull from the general population, keen to improve well-being and early detection of possibly serious health conditions and the push from the industry eager to translate the current significant progress in computer vision and machine learning into commercial products. One of such systems is the Wize Mirror, built as a result of the FP7 funded SEMEOTICONS (SEMEiotic Oriented Technology for Individuals CardiOmetabolic risk self-assessmeNt and Self-monitoring) project. The project aims to translate the semeiotic code of the human face into computational descriptors and measures, automatically extracted from videos, multispectral images, and 3D scans of the face. The multisensory platform, being developed as the result of that project, in the form of a smart mirror, looks for signs related to cardio-metabolic risks. The goal is to enable users to self-monitor their well-being status over time and improve their life-style via tailored user guidance. This paper is focused on the description of the part of that system. utilising computer vision and machine learning techniques to perform 3D morphological analysis of the face and recognition of psycho-somatic status both linked with cardio-metabolic risks. The paper describes the concepts, methods and the developed implementations as well as reports on the results obtained on both real and synthetic datasets. (C) 2016 The Authors. Published by Elsevier Inc.
C1 [Andreu, Yasmina; Henriquez, Pedro; Matuszewski, Bogdan J.] Univ Cent Lancashire, Sch Comp Engn & Phys Sci, Robot & Comp Vis Res Lab, Preston PR1 2HE, Lancs, England.
   [Colantonio, Sara; Giorgi, Daniela; Pascali, Maria Antonietta; Raccichini, Giovanni] Natl Res Council Italy, Inst Informat Sci & Technol, Via G Moruzzi 1, I-56124 Pisa, Italy.
   [Chiarugi, Franco; Giannakakis, Giorgos; Kazantzaki, Eleni; Manousos, Dimitris; Marias, Kostas; Pediaditis, Matthew; Tsiknakis, Manolis] Fdn Res & Technol Hellas FORTH, Inst Comp Sci, N Plastira 100, GR-70013 Iraklion, Crete, Greece.
   [Tsiknakis, Manolis] Technol Educ Inst Crete, Biomed Informat & eHlth Lab, GR-71004 Iraklion, Crete, Greece.
C3 University of Central Lancashire; Consiglio Nazionale delle Ricerche
   (CNR); Istituto di Scienza e Tecnologie dell'Informazione "Alessandro
   Faedo" (ISTI-CNR); Hellenic Mediterranean University
RP Colantonio, S (corresponding author), Natl Res Council Italy, Inst Informat Sci & Technol, Via G Moruzzi 1, I-56124 Pisa, Italy.
EM yasmina.andreu@gmail.com; sara.colantonio@isti.cnr.it
RI Giannakakis, Giorgos/V-5626-2019; Tsiknakis, Manolis/Z-2114-2019;
   Marias, Kostas/AAM-2330-2021; Pascali, Maria/AAU-5020-2020; Colantonio,
   Sara/AFL-2051-2022; GIORGI, DANIELA/B-3998-2017
OI GIORGI, DANIELA/0000-0002-6752-6918; Pascali, Maria
   Antonietta/0000-0001-7742-8126; Pediaditis, Matthew/0000-0003-2263-3020;
   COLANTONIO, SARA/0000-0003-2022-0804; Henriquez,
   Pedro/0000-0001-6582-5351; Tsiknakis, Manolis/0000-0001-8454-1450;
   Giannakakis, Giorgos/0000-0002-0958-5346; Marias,
   Kostas/0000-0003-3783-5223
FU European Community [611516]
FX This work has been supported by the European Community's Seventh
   Framework Programme (FP7/2013-2016) under the grant agreement number
   611516 (SEMEOTICONS). Thanks to the team from The Institute of Clinical
   Physiology of the National Research Council of Italy, namely Dr. Eng.
   Giuseppe Coppini, MD Paolo Marraccini and MD Maria-Aurora Morales, for
   their valuable collaboration in this work.
CR Alarcon G., 2012, "Introduction to Epilepsy"
   [Anonymous], IEEE P 6 IEEE INT C
   [Anonymous], 2015, Anxiety
   [Anonymous], 1994, Anthropometry of the head and face
   [Anonymous], 1950, The physiology and pathology of exposure to stress
   [Anonymous], BMJ OPEN
   [Anonymous], ESPA 2012
   [Anonymous], 2014, SYNTH LECT COMPUT GR
   [Anonymous], NAT COMM C NCC MUMB
   [Anonymous], AUTOMATIC FACE GESTU
   [Anonymous], 2014, P INT C HLTH INFORMA, DOI DOI 10.5220/0004934405550562
   [Anonymous], SYST COMPUT JPN
   [Anonymous], 37 ANN INT C IEEE EN
   Balakrishnan G, 2013, PROC CVPR IEEE, P3430, DOI 10.1109/CVPR.2013.440
   BESL PJ, 1992, IEEE T PATTERN ANAL, V14, P239, DOI 10.1109/34.121791
   Cai Q, 2010, LECT NOTES COMPUT SC, V6313, P229
   Chen H, 2013, TISSUE BARRIERS, V1, DOI 10.4161/tisb.27463
   Choi J, 2014, IEEE WINT CONF APPL, P660, DOI 10.1109/WACV.2014.6836039
   Christinaki E, 2014, 2014 EAI 4TH INTERNATIONAL CONFERENCE ON WIRELESS MOBILE COMMUNICATION AND HEALTHCARE (MOBIHEALTH), P339, DOI 10.1109/MOBIHEALTH.2014.7015980
   Cootes TF, 2001, IEEE T PATTERN ANAL, V23, P681, DOI 10.1109/34.927467
   Dugelay J.-L., 2010, Biometrics: Theory Applications and Systems (BTAS), 2010 Fourth IEEE International Conference on, P1, DOI [DOI 10.1109/BTAS.2010.5634540, 10.1109/BTAS.2010.5634540]
   EKMAN P, 1971, J PERS SOC PSYCHOL, V17, P124, DOI 10.1037/h0030377
   Fanelli Gabriele, 2011, Pattern Recognition. Proceedings 33rd DAGM Symposium, P101, DOI 10.1007/978-3-642-23123-0_11
   Farnebäck G, 2003, LECT NOTES COMPUT SC, V2749, P363, DOI 10.1007/3-540-45103-x_50
   Ferrario VF, 2004, ANGLE ORTHOD, V74, P37
   Giachetti A, 2015, IEEE J BIOMED HEALTH, V19, P660, DOI 10.1109/JBHI.2014.2314360
   Gunes H, 2007, J NETW COMPUT APPL, V30, P1334, DOI 10.1016/j.jnca.2006.09.007
   Halkidi M, 2001, J INTELL INF SYST, V17, P107, DOI 10.1023/A:1012801612483
   HAMILTON M, 1959, BRIT J MED PSYCHOL, V32, P50, DOI 10.1111/j.2044-8341.1959.tb00467.x
   Hammond P, 2007, ARCH DIS CHILD, V92, P1120, DOI 10.1136/adc.2006.103507
   Harrigan JA, 1996, PERS INDIV DIFFER, V21, P205, DOI 10.1016/0191-8869(96)00050-5
   Henriquez P, 2014, IEEE IMAGE PROC, P1957, DOI 10.1109/ICIP.2014.7025392
   Hernandez M, 2015, IMAGE VISION COMPUT, V36, P61, DOI 10.1016/j.imavis.2014.12.004
   Hojo H., 2009, IEEE REGION 10 C TEN, P1
   Irani R, 2014, PROCEEDINGS OF THE 2014 9TH INTERNATIONAL CONFERENCE ON COMPUTER VISION, THEORY AND APPLICATIONS (VISAPP 2014), VOL 3, P118
   Kojovic Maja, 2011, Ther Adv Neurol Disord, V4, P47, DOI 10.1177/1756285610395653
   Koolhaas JM, 2011, NEUROSCI BIOBEHAV R, V35, P1291, DOI 10.1016/j.neubiorev.2011.02.003
   Lee BJ, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-248
   Lee BJ, 2012, J BIOMED BIOTECHNOL, DOI 10.1155/2012/818607
   Li C, 2007, OBESITY, V15, P216, DOI 10.1038/oby.2007.505
   Lin JD, 2004, CLIN NUTR, V23, P1313, DOI 10.1016/j.clnu.2004.04.005
   Lucas Bruce D., ITERATIVE IMAGE REGI, P674
   Malassiotis S, 2005, PATTERN RECOGN, V38, P1153, DOI 10.1016/j.patcog.2004.11.020
   Manousos D, 2014, 2014 EAI 4TH INTERNATIONAL CONFERENCE ON WIRELESS MOBILE COMMUNICATION AND HEALTHCARE (MOBIHEALTH), P335, DOI 10.1109/MOBIHEALTH.2014.7015979
   Marcio A.C. S. S., 2013, SBC J 3D INTERACTIVE, V4, P2
   Matthews I, 2004, INT J COMPUT VISION, V60, P135, DOI 10.1023/B:VISI.0000029666.37597.d3
   Murphy-Chutorian E, 2009, IEEE T PATTERN ANAL, V31, P607, DOI 10.1109/TPAMI.2008.106
   Newcombe RA, 2011, INT SYM MIX AUGMENT, P127, DOI 10.1109/ISMAR.2011.6092378
   Niles AN, 2015, J PSYCHOSOM RES, V78, P109, DOI 10.1016/j.jpsychores.2014.11.018
   Oliver N, 2000, PATTERN RECOGN, V33, P1369, DOI 10.1016/S0031-3203(99)00113-2
   Padeleris P., 2012, 2012 IEEE COMPUTER S, P42
   Quan W, 2010, IEEE IMAGE PROC, P2433, DOI 10.1109/ICIP.2010.5651357
   Raytchev B, 2004, INT C PATT RECOG, P462, DOI 10.1109/ICPR.2004.1333802
   Reyment RA, 1996, NATO ADV SCI INST SE, V284, P15
   Romero LM, 2004, TRENDS ECOL EVOL, V19, P249, DOI 10.1016/j.tree.2004.03.008
   Sardinha A, 2012, EXPERT REV ENDOCRINO, V7, P63, DOI [10.1586/EEM.11.89, 10.1586/eem.11.89]
   Seemann E, 2004, SIXTH IEEE INTERNATIONAL CONFERENCE ON AUTOMATIC FACE AND GESTURE RECOGNITION, PROCEEDINGS, P626, DOI 10.1109/AFGR.2004.1301603
   Sharma N, 2012, COMPUT METH PROG BIO, V108, P1287, DOI 10.1016/j.cmpb.2012.07.003
   Shin LM, 2010, NEUROPSYCHOPHARMACOL, V35, P169, DOI 10.1038/npp.2009.83
   Sierra-Johnson J, 2004, MED HYPOTHESES, V63, P783, DOI 10.1016/j.mehy.2004.06.020
   Smeets D, 2013, COMPUT VIS IMAGE UND, V117, P158, DOI 10.1016/j.cviu.2012.10.002
   Thompson DW., 1917, GROWTH FORM
   Wang J, 2006, AM J CLIN NUTR, V83, P809
   Wells JCK, 2008, INT J OBESITY, V32, P152, DOI 10.1038/sj.ijo.0803685
   Xiaozheng Mou, 2012, Proceedings of the 2012 IEEE International Conference on Robotics and Biomimetics (ROBIO), P470, DOI 10.1109/ROBIO.2012.6491011
   Zollhöfer M, 2011, COMPUT ANIMAT VIRT W, V22, P195, DOI 10.1002/cav.405
NR 66
TC 30
Z9 41
U1 0
U2 18
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1077-3142
EI 1090-235X
J9 COMPUT VIS IMAGE UND
JI Comput. Vis. Image Underst.
PD JUL
PY 2016
VL 148
BP 3
EP 22
DI 10.1016/j.cviu.2016.03.018
PG 20
WC Computer Science, Artificial Intelligence; Engineering, Electrical &
   Electronic
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Computer Science; Engineering
GA DP4GS
UT WOS:000378455000002
OA hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Scannell, N
   Villani, A
   Moran, L
   Mantzioris, E
AF Scannell, Nicole
   Villani, Anthony
   Moran, Lisa
   Mantzioris, Evangeline
TI The potential role of the Mediterranean diet for the treatment and
   management of polycystic ovary syndrome: a review of the
   pathophysiological mechanisms and clinical evidence
SO PROCEEDINGS OF THE NUTRITION SOCIETY
LA English
DT Review; Early Access
DE Polycystic ovary syndrome; Mediterranean diet; Insulin resistance;
   Cardiometabolic; Reproductive; Psychological; Anti-inflammatory
ID POLYUNSATURATED FATTY-ACIDS; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   INFLAMMATORY PROCESSES; METABOLIC SYNDROME; DIABETES-MELLITUS; ANXIETY
   SYMPTOMS; CENTRAL OBESITY; MENTAL-HEALTH; SYNDROME PCOS
AB Polycystic ovary syndrome (PCOS) is a common endocrine disorder amongst reproductive-aged women associated with cardiometabolic, reproductive and psychological abnormalities. Lifestyle modification, including a healthy diet, is considered first-line treatment for management of clinical symptoms. However, there is limited high-quality evidence to support one superior therapeutic dietary intervention for PCOS management that is beyond general population-based dietary guidelines. Adherence to a Mediterranean diet (MedDiet) has been shown to decrease cardiometabolic disease risk and attenuate depressive symptoms, particularly in patients with metabolic perturbations. This narrative review summarises the proposed biological mechanisms underpinning the potential therapeutic benefits of a MedDiet for the management of cardiometabolic, reproductive and psychological features related to PCOS. Observational evidence suggests an inverse relationship between MedDiet adherence and PCOS features, particularly insulin resistance and hyperandrogenemia. Although the exact mechanisms are complex and multifaceted, they are likely related to the anti-inflammatory potential of the dietary pattern. These mechanisms are underpinned by anti-inflammatory bioactive constituents present in the MedDiet, including carotenoids, polyphenols and n-3 polyunsaturated fatty acids (PUFAs). Synthesis of the available literature suggests the MedDiet could be a promising therapeutic dietary intervention to attenuate short and long-term symptoms associated with PCOS and may aid in reducing the longer-term risks associated with cardiometabolic diseases and reproductive and psychological dysfunction. Nevertheless, current evidence remains insufficient to inform clinical practice and well-designed clinical trials are needed. As such, we provide recommendations for the design and delivery of future MedDiet interventions in women with PCOS, including exploring the acceptability, and feasibility to enhance adherence.
C1 [Scannell, Nicole; Villani, Anthony] Univ Sunshine Coast, Sch Hlth, Sippy Downs, Qld, Australia.
   [Moran, Lisa] Monash Univ, Monash Ctr Hlth Res & Implementat MCHRI, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia.
   [Mantzioris, Evangeline] Univ South Australia, UniSA Clin & Hlth Sci, Alliance Res Exercise Nutr & Act ARENA, Adelaide, SA, Australia.
C3 University of the Sunshine Coast; Monash University; University of South
   Australia
RP Mantzioris, E (corresponding author), Univ South Australia, UniSA Clin & Hlth Sci, Alliance Res Exercise Nutr & Act ARENA, Adelaide, SA, Australia.
EM evangeline.mantzioris@unisa.edu.au
RI Moran, Lisa/E-9850-2015; Scannell, Nicole/ITU-5871-2023; Mantzioris,
   Evangeline/G-8681-2011
OI Mantzioris, Evangeline/0000-0002-1480-9869; Scannell,
   Nicole/0000-0002-2097-7631
CR Abodi M, 2022, EUR J OBSTET GYN R B, V275, P97, DOI 10.1016/j.ejogrb.2022.06.019
   Aboeldalyl S, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22052734
   Agnoli C, 2018, NUTR DIABETES, V8, DOI 10.1038/s41387-018-0023-3
   Al-Gubory KH, 2010, INT J BIOCHEM CELL B, V42, P1634, DOI 10.1016/j.biocel.2010.06.001
   Alesi S, 2022, NUTRIENTS, V14, DOI 10.3390/nu14193914
   Braga DPAF, 2015, REPROD BIOMED ONLINE, V31, P30, DOI 10.1016/j.rbmo.2015.03.007
   Alpañés M, 2012, EXPERT REV ENDOCRINO, V7, P91, DOI [10.1586/eem.11.85, 10.1586/EEM.11.85]
   ALTUN A, 2019, NEUROL PSYCHIAT BR, V33, P1, DOI DOI 10.1016/J.NPBR.2019.05.007
   Anagnostis P, 2018, METABOLISM, V86, P33, DOI 10.1016/j.metabol.2017.09.016
   Anckaert E, 2010, BIOL REPROD, V83, P377, DOI 10.1095/biolreprod.109.082164
   Appleton KM, 2023, J NUTR SCI, V12, DOI 10.1017/jns.2023.2
   Arentz S, 2021, BMC WOMENS HEALTH, V21, DOI 10.1186/s12905-021-01252-1
   Azziz R, 2009, FERTIL STERIL, V91, P456, DOI 10.1016/j.fertnstert.2008.06.035
   Balen AH, 2007, BMJ-BRIT MED J, V335, P663, DOI 10.1136/bmj.39335.462303.80
   Barbosa G., 2016, Open J Endocrine Metab Dis, V6, P58, DOI 10.4236/ojemd.2016.61008
   Barcikowska Z, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17041191
   Barrea L, 2021, NUTRIENTS, V13, DOI 10.3390/nu13113925
   Barrea L, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102278
   Bayes J, 2020, ADV NUTR, V11, P602, DOI 10.1093/advances/nmz117
   Bendall CL, 2018, CRIT REV FOOD SCI, V58, P3070, DOI 10.1080/10408398.2017.1351917
   Berding K, 2021, ADV NUTR, V12, P1239, DOI 10.1093/advances/nmaa181
   Bhaswant M, 2015, J NUTR BIOCHEM, V26, P571, DOI 10.1016/j.jnutbio.2015.02.001
   Bizzozero-Peroni B, 2024, NUTR REV, V83, P29, DOI 10.1093/nutrit/nuad176
   Black PH, 2003, BRAIN BEHAV IMMUN, V17, P350, DOI 10.1016/S0889-1591(03)00048-5
   Cadagan D, 2016, REPROD BIOL, V16, P53, DOI 10.1016/j.repbio.2015.12.006
   Calder PC, 2017, BIOCHEM SOC T, V45, P1105, DOI 10.1042/BST20160474
   Calder PC, 2015, BBA-MOL CELL BIOL L, V1851, P469, DOI 10.1016/j.bbalip.2014.08.010
   Calder PC, 2013, BRIT J CLIN PHARMACO, V75, P645, DOI 10.1111/j.1365-2125.2012.04374.x
   Carpi S, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122855
   Casas R, 2016, J NUTR, V146, P1684, DOI 10.3945/jn.115.229476
   Cassar S, 2016, HUM REPROD, V31, P2619, DOI 10.1093/humrep/dew243
   Chaudhari N, 2018, REPROD BIOL ENDOCRIN, V16, DOI 10.1186/s12958-018-0354-x
   Chen TH, 2004, HUM REPROD, V19, P2313, DOI 10.1093/humrep/deh414
   Chiriacò M, 2023, NUTR METAB CARDIOVAS, V33, P724, DOI 10.1016/j.numecd.2023.01.024
   Chrysohoou C, 2004, J AM COLL CARDIOL, V44, P152, DOI 10.1016/j.jacc.2004.03.039
   Clifford D, 2015, J NUTR EDUC BEHAV, V47, P143, DOI 10.1016/j.jneb.2014.12.002
   Cooney LG, 2017, HUM REPROD, V32, P1075, DOI 10.1093/humrep/dex044
   Cutillas-Tolín A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020313
   Damone AL, 2019, PSYCHOL MED, V49, P1510, DOI 10.1017/S0033291718002076
   Davis CR, 2015, BMC Nutr, V1, P28, DOI [DOI 10.1186/S40795-015-0021-Y, 10.1186/s40795-015-0021-y]
   de Groot PCM, 2011, HUM REPROD UPDATE, V17, P495, DOI 10.1093/humupd/dmr001
   Deeks AA, 2010, FERTIL STERIL, V93, P2421, DOI 10.1016/j.fertnstert.2009.09.018
   Delgado-Lista J, 2022, LANCET, V399, P1876, DOI 10.1016/S0140-6736(22)00122-2
   Deswal Ritu, 2020, J Hum Reprod Sci, V13, P261, DOI 10.4103/jhrs.JHRS_95_18
   Dhanya R, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00336
   Diamanti-Kandarakis E, 2006, TRENDS MOL MED, V12, P324, DOI 10.1016/j.molmed.2006.05.006
   Diamanti-Kandarakis E, 2012, ENDOCR REV, V33, P981, DOI 10.1210/er.2011-1034
   Dokras A, 2012, FERTIL STERIL, V97, P225, DOI 10.1016/j.fertnstert.2011.10.022
   Eid HM, 2010, MOL NUTR FOOD RES, V54, P991, DOI 10.1002/mnfr.200900218
   Elce A, 2017, BENEF MICROBES, V8, P841, DOI 10.3920/BM2016.0197
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   Esposito K, 2014, DIABETES CARE, V37, P1824, DOI 10.2337/dc13-2899
   Estruch R, 2018, NEW ENGL J MED, V378, DOI [10.1056/NEJMoa1800389, 10.1056/NEJMoa1200303, 10.1056/nejmoa1800389]
   Farland LV, 2022, HUM REPROD, V37, P2690, DOI 10.1093/humrep/deac210
   Fauser BCJM, 2012, FERTIL STERIL, V97, P28, DOI 10.1016/j.fertnstert.2011.09.024
   Feng JG, 2018, J COSMET DERMATOL-US, V17, P511, DOI 10.1111/jocd.12387
   Fiedor J, 2014, NUTRIENTS, V6, P466, DOI 10.3390/nu6020466
   Firns S, 2015, REPROD BIOL ENDOCRIN, V13, DOI 10.1186/s12958-015-0133-x
   Foscolou A, 2024, CHILDREN-BASEL, V11, DOI 10.3390/children11060635
   Galié S, 2021, CLIN NUTR, V40, P3798, DOI 10.1016/j.clnu.2021.04.028
   Garruti G, 2019, CURR MED CHEM, V26, P3584, DOI 10.2174/0929867324666170518101008
   Gaskins AJ, 2019, AM J OBSTET GYNECOL, V220, DOI 10.1016/j.ajog.2019.02.004
   Gonzalez MB, 2018, J REPROD IMMUNOL, V130, P25, DOI 10.1016/j.jri.2018.08.005
   González-Gallego J, 2010, BRIT J NUTR, V104, pS15, DOI 10.1017/S0007114510003910
   Greenwood EA, 2018, FERTIL STERIL, V110, P27, DOI 10.1016/j.fertnstert.2018.03.009
   Grosso G, 2022, NUTRIENTS, V14, DOI 10.3390/nu14030545
   Gutierrez-Mariscal FM, 2021, MOL NUTR FOOD RES, V65, DOI 10.1002/mnfr.201901290
   Himelein MJ, 2006, OBSTET GYNECOL SURV, V61, P723, DOI 10.1097/01.ogx.0000243772.33357.84
   Holsboer F, 2010, ANNU REV PSYCHOL, V61, P81, DOI 10.1146/annurev.psych.093008.100321
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Humphreys L, 2008, J R SOC PROMO HEALTH, V128, P190, DOI 10.1177/1466424008092230
   Hussain T, 2020, PHARMACOL RES, V152, DOI 10.1016/j.phrs.2020.104629
   Itsiopoulos C, 2011, NUTR METAB CARDIOVAS, V21, P740, DOI 10.1016/j.numecd.2010.03.005
   Jacka FN, 2017, BMC MED, V15, DOI 10.1186/s12916-017-0791-y
   Janssen OE, 2008, SEMIN REPROD MED, V26, P45, DOI 10.1055/s-2007-992924
   Jena Debarchan, 2018, Indian J Endocrinol Metab, V22, P321, DOI 10.4103/ijem.IJEM_646_17
   Joham AE, 2022, LANCET DIABETES ENDO, V10, P668, DOI 10.1016/S2213-8587(22)00163-2
   Jones GL, 2008, HUM REPROD UPDATE, V14, P15
   Joseph DN, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18102224
   Kakoly NS, 2018, HUM REPROD UPDATE, V24, P455, DOI 10.1093/humupd/dmy007
   Karayiannis D, 2018, HUM REPROD, V33, P494, DOI 10.1093/humrep/dey003
   Karjula S, 2020, J CLIN ENDOCR METAB, V105, P1814, DOI 10.1210/clinem/dgz256
   Kataoka J, 2017, NUTRIENTS, V9, DOI 10.3390/nu9090996
   Kerchner A, 2009, FERTIL STERIL, V91, P207, DOI 10.1016/j.fertnstert.2007.11.022
   Knudsen KEB, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101499
   Kolhe JV, 2022, REPROD SCI, V29, P3106, DOI 10.1007/s43032-021-00765-2
   Kopel E, 2014, ANN INTERN MED, V161, P157, DOI [10.7326/L14-5014, 10.7326/M13-1725, 10.7326/L14-5014-2]
   Lara J, 2015, MATURITAS, V82, P387, DOI 10.1016/j.maturitas.2015.07.029
   Lazurova I, 2019, PHYSIOL RES, V68, P457, DOI 10.33549/physiolres.934062
   Lee I, 2019, EAT WEIGHT DISORD-ST, V24, P787, DOI 10.1007/s40519-018-0533-y
   Lee I, 2017, FERTIL STERIL, V107, P796, DOI 10.1016/j.fertnstert.2016.12.014
   Legro RS, 1999, J CLIN ENDOCR METAB, V84, P165, DOI 10.1210/jc.84.1.165
   Li Y, 2018, BIORESEARCH OPEN ACC, V7, P116, DOI 10.1089/biores.2017.0040
   Lim JJ, 2017, ENDOCRINOLOGY, V158, P993, DOI 10.1210/en.2016-1866
   Lim SS, 2013, OBES REV, V14, P95, DOI 10.1111/j.1467-789X.2012.01053.x
   Lim SS, 2012, HUM REPROD UPDATE, V18, P618, DOI 10.1093/humupd/dms030
   Lim S, 2021, HEALTH PROMOT J AUST, V32, P41, DOI 10.1002/hpja.349
   Lim SS, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007506.pub4
   Liu RH, 2013, ADV NUTR, V4, p384S, DOI 10.3945/an.112.003517
   Luisi MLE, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.01366
   Maiorino MI, 2018, J ENDOCRINOL INVEST, V41, P1249, DOI 10.1007/s40618-018-0872-6
   Mantzioris E, 2022, PROSTAG LEUKOTR ESS, V176, DOI 10.1016/j.plefa.2021.102387
   Mantzioris E, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102507
   Marx W, 2021, MOL PSYCHIATR, V26, P134, DOI 10.1038/s41380-020-00925-x
   McLoughlin RF, 2017, AM J CLIN NUTR, V106, P930, DOI 10.3945/ajcn.117.156265
   Mei SS, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.876620
   Melo AS, 2015, CLINICS, V70, P765
   Miller AH, 2009, BIOL PSYCHIAT, V65, P732, DOI 10.1016/j.biopsych.2008.11.029
   Milte CM, 2016, EUR J NUTR, V55, P423, DOI 10.1007/s00394-015-1123-7
   Moghetti P, 2021, J ENDOCRINOL INVEST, V44, P233, DOI 10.1007/s40618-020-01351-0
   Mohammadi MM, 2022, EUR J CLIN PHARMACOL, V78, P721, DOI 10.1007/s00228-021-03263-1
   Moran LJ, 2019, NUTRIENTS, V11, DOI 10.3390/nu11030492
   Moran LJ, 2016, NUTRIENTS, V8, DOI 10.3390/nu8010010
   Moran LJ, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007506.pub3
   Moran LJ, 2015, NUTRIENTS, V7, P8553, DOI 10.3390/nu7105419
   Moran LJ, 2013, HUM REPROD UPDATE, V19, P432, DOI 10.1093/humupd/dmt015
   Moran LJ, 2009, FERTIL STERIL, V92, P1966, DOI 10.1016/j.fertnstert.2008.09.018
   Nabavi SF, 2015, CURR MED CHEM, V22, P343
   Nanba AT, 2019, J CLIN ENDOCR METAB, V104, P2615, DOI 10.1210/jc.2018-02527
   Nani A, 2021, MOLECULES, V26, DOI 10.3390/molecules26040985
   Natto ZS, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-54535-x
   Nemer LB, 2019, REPROD SCI, V26, P404, DOI 10.1177/1933719118776787
   Noah A, 2001, ASIA PAC J CLIN NUTR, V10, P2, DOI 10.1046/j.1440-6047.2001.00198.x
   Noli SA, 2023, REPROD BIOMED ONLINE, V47, P77, DOI 10.1016/j.rbmo.2023.03.011
   O'Reilly MW, 2017, J CLIN ENDOCR METAB, V102, P840, DOI 10.1210/jc.2016-3285
   Obeid CA, 2022, EUR J NUTR, V61, P3327, DOI 10.1007/s00394-022-02885-0
   Onieva-Zafra MD, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061759
   Orisaka M, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1324429
   Parletta N, 2019, NUTR NEUROSCI, V22, P474, DOI 10.1080/1028415X.2017.1411320
   Pereira SS, 2014, CURR OBES REP, V3, P422, DOI 10.1007/s13679-014-0124-9
   Pierre A, 2017, J CLIN ENDOCR METAB, V102, P3970, DOI 10.1210/jc.2017-00308
   Qiao J, 2011, HUM REPROD UPDATE, V17, P17, DOI 10.1093/humupd/dmq032
   Rangel-Huerta OD, 2012, BRIT J NUTR, V107, pS159, DOI 10.1017/S0007114512001559
   Rees DA, 2016, J CLIN ENDOCR METAB, V101, P1664, DOI 10.1210/jc.2015-2682
   Rehman R, 2018, INT J REPROD BIOMED, V16, P529
   Ricci E, 2019, AM J OBSTET GYNECOL, V221, DOI 10.1016/j.ajog.2019.07.011
   Rice S, 2005, HUM REPROD, V20, P373, DOI 10.1093/humrep/deh609
   Richard C, 2013, OBESITY, V21, P51, DOI 10.1002/oby.20239
   Rostamtabar M, 2021, J CELL PHYSIOL, V236, P824, DOI 10.1002/jcp.29912
   Rudnicka E, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22073789
   Salas-Salvadó J, 2019, DIABETES CARE, V42, P777, DOI 10.2337/dc18-0836
   Sanchez-Rodriguez E, 2021, J FUNCT FOODS, V83, DOI 10.1016/j.jff.2021.104561
   Scannell N, 2022, METABOLITES, V12, DOI 10.3390/metabo12040311
   Scannell N, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17249321
   Shafiei F, 2019, NUTR REV, V77, P230, DOI 10.1093/nutrit/nuy070
   Silva JRV, 2020, ZYGOTE, V28, P270, DOI 10.1017/S0967199420000222
   Singh MK, 2019, HORM BEHAV, V108, P73, DOI 10.1016/j.yhbeh.2018.03.009
   Skiba MA, 2018, HUM REPROD UPDATE, V24, P694, DOI 10.1093/humupd/dmy022
   Snipe RMJ, 2024, NUTR DIET, V81, P94, DOI 10.1111/1747-0080.12835
   Standeven LR., 2023, Adv Psychiatry Behav Health
   Stephenson J, 2018, LANCET, V391, P1830, DOI [10.1016/S0140-6736(18)30311-8, 10.1016/s0140-6736(18)30311-8]
   Stepto NK, 2019, J CLIN ENDOCR METAB, V104, P5369, DOI 10.1210/jc.2019-00167
   Stepto NK, 2013, HUM REPROD, V28, P777, DOI 10.1093/humrep/des463
   Sun HM, 2019, REPROD BIOL ENDOCRIN, V17, DOI 10.1186/s12958-019-0520-9
   Sureda A, 2018, NUTRIENTS, V10, DOI 10.3390/nu10010062
   Tay CT, 2019, FERTIL STERIL, V112, P353, DOI 10.1016/j.fertnstert.2019.03.027
   Teede H, 2010, BMC MED, V8, DOI 10.1186/1741-7015-8-41
   Teede H, 2023, International evidence-based guideline for the assessment and management of polycystic ovary syndrome 2023
   Teede H, 2019, TRENDS ENDOCRIN MET, V30, P467, DOI 10.1016/j.tem.2019.04.006
   Teede HJ, 2023, J CLIN ENDOCR METAB, DOI 10.1210/clinem/dgad463
   Teede HJ, 2018, FERTIL STERIL, V110, P364, DOI 10.1016/j.fertnstert.2018.05.004
   Teede HJ, 2011, MED J AUSTRALIA, V195, pS69, DOI 10.5694/mja11.10915
   Thannickal A, 2020, CLIN ENDOCRINOL, V92, P338, DOI 10.1111/cen.14153
   Thomann R, 2008, GYNECOL ENDOCRINOL, V24, P199, DOI 10.1080/09513590801893398
   Thombare K, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0177605
   Trebble TM, 2003, AM J CLIN NUTR, V78, P376, DOI 10.1093/ajcn/78.3.376
   Trichopoulou A, 2014, BMC MED, V12, DOI 10.1186/1741-7015-12-112
   Upritchard JE, 2000, DIABETES CARE, V23, P733, DOI 10.2337/diacare.23.6.733
   Velez LM, 2021, BIOL REPROD, V104, P1205, DOI 10.1093/biolre/ioab050
   Ventriglio Antonio, 2020, Clin Pract Epidemiol Ment Health, V16, P156, DOI 10.2174/1745017902016010156
   Wannamethee SG, 2006, AM J CLIN NUTR, V83, P567, DOI 10.1093/ajcn.83.3.567
   Willett Walter C., 1995, American Journal of Clinical Nutrition, V61, p1402S, DOI 10.1093/ajcn/61.6.1402S
   Williams T, 2016, AM FAM PHYSICIAN, V94, P106
   Winiarska-Mieczan A, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24032258
   Wolf WM, 2018, J CLIN MED, V7, DOI 10.3390/jcm7110395
   Xing LW, 2022, FRONT PSYCHIATRY, V13, DOI 10.3389/fpsyt.2022.1001484
   Xu F, 2017, CELL MOL BIOL, V63, P64, DOI 10.14715/cmb/2017.63.10.10
   Yadav A., 2022, Obstet. Gynaecol. Reprod. Med, V32, P197, DOI [10.1016/j.ogrm.2022.06.001, DOI 10.1016/J.OGRM.2022.06.001]
   Yahfoufi N, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111618
   Yubero-Serrano EM, 2020, PLOS MED, V17, DOI 10.1371/journal.pmed.1003282
   Zacharia K, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041044
   Zaragoza-Martí A, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2017-019033
   Zeng X, 2020, CLIN CHIM ACTA, V502, P214, DOI 10.1016/j.cca.2019.11.003
   Zhao LQ, 2016, ONCOTARGET, V7, P33715, DOI 10.18632/oncotarget.9553
NR 184
TC 1
Z9 1
U1 3
U2 3
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0029-6651
EI 1475-2719
J9 P NUTR SOC
JI Proc. Nutr. Soc.
PD 2024 NOV 19
PY 2024
DI 10.1017/S0029665124007584
EA NOV 2024
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA O8G8P
UT WOS:001373454100001
PM 39558903
OA Bronze
DA 2025-06-11
ER

PT J
AU Stiglic, N
   Viner, RM
AF Stiglic, Neza
   Viner, Russell M.
TI Effects of screentime on the health and well-being of children and
   adolescents: a systematic review of reviews
SO BMJ OPEN
LA English
DT Review
ID SCHOOL-AGED CHILDREN; SEDENTARY BEHAVIOR; INDICATORS; VIOLENCE
AB Objectives To systematically examine the evidence of harms and benefits relating to time spent on screens for children and young people's (CYP) health and well-being, to inform policy.
   Methods Systematic review of reviews undertaken to answer the question 'What is the evidence for health and well-being effects of screentime in children and adolescents (CYP)?' Electronic databases were searched for systematic reviews in February 2018. Eligible reviews reported associations between time on screens (screentime; any type) and any health/well-being outcome in CYP. Quality of reviews was assessed and strength of evidence across reviews evaluated.
   Results 13 reviews were identified (1 high quality, 9 medium and 3 low quality). 6 addressed body composition; 3 diet/energy intake; 7 mental health; 4 cardiovascular risk; 4 for fitness; 3 for sleep; 1 pain; 1 asthma. We found moderately strong evidence for associations between screentime and greater obesity/adiposity and higher depressive symptoms; moderate evidence for an association between screentime and higher energy intake, less healthy diet quality and poorer quality of life. There was weak evidence for associations of screentime with behaviour problems, anxiety, hyperactivity and inattention, poorer self-esteem, poorer well-being and poorer psychosocial health, metabolic syndrome, poorer cardiorespiratory fitness, poorer cognitive development and lower educational attainments and poor sleep outcomes. There was no or insufficient evidence for an association of screentime with eating disorders or suicidal ideation, individual cardiovascular risk factors, asthma prevalence or pain. Evidence for threshold effects was weak. We found weak evidence that small amounts of daily screen use is not harmful and may have some benefits.
   Conclusions There is evidence that higher levels of screentime is associated with a variety of health harms for CYP, with evidence strongest for adiposity, unhealthy diet, depressive symptoms and quality of life. Evidence to guide policy on safe CYP screentime exposure is limited.
C1 [Stiglic, Neza; Viner, Russell M.] UCL Inst Child Hlth, Populat Policy & Practice Res Programme, London, England.
C3 University of London; University College London
RP Viner, RM (corresponding author), UCL Inst Child Hlth, Populat Policy & Practice Res Programme, London, England.
EM r.viner@ucl.ac.uk
RI Viner, Russell/A-1441-2009
OI Viner, Russell/0000-0003-3047-2247
CR [Anonymous], 2013, INT J BEHAV NUTR PHY, DOI DOI 10.1186/1479-5868-10-102
   [Anonymous], EVIDENCE POLICY
   [Anonymous], J PAEDIAT CHILD HLTH
   Carson V, 2016, APPL PHYSIOL NUTR ME, V41, pS240, DOI 10.1139/apnm-2015-0630
   Costigan SA, 2013, J ADOLESCENT HEALTH, V52, P382, DOI 10.1016/j.jadohealth.2012.07.018
   de Oliveira RG, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0168503
   Etchells P., 2016, Guardian
   Ferguson CJ, 2017, PREV MED, V99, P69, DOI 10.1016/j.ypmed.2017.02.009
   Hale L, 2015, SLEEP MED REV, V21, P50, DOI 10.1016/j.smrv.2014.07.007
   Hoare E, 2016, INT J BEHAV NUTR PHY, V13, DOI 10.1186/s12966-016-0432-4
   Iannotti RJ, 2009, INT J PUBLIC HEALTH, V54, P191, DOI 10.1007/s00038-009-5410-z
   Jago R, 2011, INT J BEHAV NUTR PHY, V8, DOI 10.1186/1479-5868-8-85
   KLESGES RC, 1993, PEDIATRICS, V91, P281
   LeBlanc AG, 2012, APPL PHYSIOL NUTR ME, V37, P753, DOI [10.1139/H2012-063, 10.1139/h2012-063]
   Marsh S, 2013, APPETITE, V71, P259, DOI 10.1016/j.appet.2013.08.017
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Pearson N, 2011, AM J PREV MED, V41, P178, DOI 10.1016/j.amepre.2011.05.002
   Ponti M, 2017, PAED CHILD HEALT-CAN, V22, P461, DOI 10.1093/pch/pxx123
   Przybylski AK, 2017, PSYCHOL SCI, V28, P204, DOI 10.1177/0956797616678438
   Reid AE, 2016, PEDIATRICS, V137, DOI 10.1542/peds.2015-3603
   Shackleton N, 2016, HEALTH PLACE, V39, P168, DOI 10.1016/j.healthplace.2016.04.002
   Straker L, 2018, J PEDIATR-US, V202, P300, DOI 10.1016/j.jpeds.2018.07.019
   Suchert V, 2015, PREV MED, V76, P48, DOI 10.1016/j.ypmed.2015.03.026
   Thomson D, 2010, RES SYNTH METHODS, V1, P198, DOI 10.1002/jrsm.30
   Tremblay MS, 2011, INT J BEHAV NUTR PHY, V8, DOI 10.1186/1479-5868-8-98
   van Ekris E, 2016, OBES REV, V17, P833, DOI 10.1111/obr.12426
   Wu XY, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0187668
NR 27
TC 612
Z9 661
U1 36
U2 405
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD JUN
PY 2019
VL 9
IS 1
AR e023191
DI 10.1136/bmjopen-2018-023191
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IC6XU
UT WOS:000471116800085
PM 30606703
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Guo, YR
   Hsu, YH
   Liang, A
   Lu, WJ
   Wu, CH
   Lee, HC
   Huang, SY
AF Guo, Yu-Ru
   Hsu, Yi-Hao
   Liang, An
   Lu, Wan-Jung
   Wu, Chi-Hao
   Lee, Hsiu-Chuan
   Huang, Shih-Yi
TI n-3 Polyunsaturated fatty acids ameliorate cognitive age-related
   impairments and depressive behaviour in unchallenged aged prediabetic
   rats
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Fatty acid; Cognitive impairment; Depression
ID METABOLIC SYNDROME; DOCOSAHEXAENOIC ACID; INSULIN-RESISTANCE;
   DOUBLE-BLIND; RISK-FACTOR; OLD-AGE; BRAIN; OMEGA-3-FATTY-ACIDS;
   EXPRESSION; MEMORY
AB Epidemiological studies have reported that nutritional deficit of n-3 polyunsaturated fatty acids (PUFAs) is closely related to depression and cognitive impairment in middle and later life. This study investigated the preventive effects of n-3 PUFA-rich oils on the behavioural impairment of unchallenged aged prediabetic rats by using a Morris water maze (MWM) test and forced swimming test (FST). Twenty 102-wk-old male SD male rats received a 35% sucrose solution and were fed with fish oil or flaxseed oil diets for 8 wk. Both treatments reduced the production of IL-6 and non-esterified fatty acids significantly. Both treatments demonstrated significantly quicker MWM acquisition, shorter FST immobility time and higher levels of nerve growth factor than did the control group. Thus, n-3 PUFA-rich oil might produce protective effects by improving fasting blood sugar levels and reducing proinflammatory cytokine levels, thus preventing cognitive age-related impairments and depression-like behaviour in aged prediabetic rats. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Guo, Yu-Ru; Hsu, Yi-Hao; Liang, An; Lu, Wan-Jung; Wu, Chi-Hao; Lee, Hsiu-Chuan; Huang, Shih-Yi] Taipei Med Univ, Sch Nutr & Hlth Sci, Taipei 110, Taiwan.
C3 Taipei Medical University
RP Lee, HC (corresponding author), Taipei Med Univ, Sch Nutr & Hlth Sci, 250 Wu Xing St, Taipei 110, Taiwan.
EM joycelee@tmu.edu.tw; sihuang@tmu.edu.tw
RI Huang, Shih-Yi/R-3495-2018; Wu, chihao/G-3512-2011
OI Guo, Yu-Ru/0000-0003-0093-8368; Huang, Shih-Yi/0000-0003-2914-5513
FU Ministry of Science and Technology, Taiwan [NSC101-2320-B-038-020-MY2,
   NSC101-2811-B-038-006, NSC102-2313-B-038-003-MY2,
   MOST103-2320-B-038-012-MY3]
FX This study was partially supported by grants (NSC101-2320-B-038-020-MY2,
   NSC101-2811-B-038-006, NSC102-2313-B-038-003-MY2, and
   MOST103-2320-B-038-012-MY3) from the Ministry of Science and Technology,
   Taiwan.
CR Agrawal R, 2012, J PHYSIOL-LONDON, V590, P2485, DOI 10.1113/jphysiol.2012.230078
   Altobelli GG, 2015, BRAIN RES, V1610, P89, DOI 10.1016/j.brainres.2015.03.029
   Bach SA, 2014, NUTR NEUROSCI, V17, P186, DOI 10.1179/1476830513Y.0000000087
   Baglietto-Vargas D, 2010, J ALZHEIMERS DIS, V21, P119, DOI 10.3233/JAD-2010-100066
   Birch AM, 2013, NEUROPHARMACOLOGY, V75, P255, DOI 10.1016/j.neuropharm.2013.07.023
   Bloss EB, 2010, J NEUROSCI, V30, P6726, DOI 10.1523/JNEUROSCI.0759-10.2010
   Bordier L, 2014, DIABETES METAB, V40, P331, DOI 10.1016/j.diabet.2014.02.002
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Breslow JL, 2006, AM J CLIN NUTR, V83, p1477S, DOI 10.1093/ajcn/83.6.1477S
   Butters MA, 2004, ARCH GEN PSYCHIAT, V61, P587, DOI 10.1001/archpsyc.61.6.587
   Calder PC, 2015, BBA-MOL CELL BIOL L, V1851, P469, DOI 10.1016/j.bbalip.2014.08.010
   Calder PC, 2006, AM J CLIN NUTR, V83, p1505S, DOI 10.1093/ajcn/83.6.1505S
   Canetti L, 2014, ARCH PHYSIOL BIOCHEM, V120, P34, DOI 10.3109/13813455.2013.868002
   Chiu CC, 2003, EUR NEUROPSYCHOPHARM, V13, P99, DOI 10.1016/S0924-977X(02)00130-X
   Cole GM, 2009, PROSTAG LEUKOTR ESS, V81, P213, DOI 10.1016/j.plefa.2009.05.015
   Cutuli D, 2014, FRONT AGING NEUROSCI, V6, DOI 10.3389/fnagi.2014.00220
   De la Fuente M, 2009, CURR PHARM DESIGN, V15, P3003, DOI 10.2174/138161209789058110
   Denis I, 2013, AGEING RES REV, V12, P579, DOI 10.1016/j.arr.2013.01.007
   Dittrich M, 2015, EUR J NUTR, V54, P881, DOI 10.1007/s00394-014-0764-2
   Dobson R, 2016, INT J OBESITY, V40, P153, DOI 10.1038/ijo.2015.151
   Farooqui AA, 2012, CELL MOL LIFE SCI, V69, P741, DOI 10.1007/s00018-011-0840-1
   Ferraz AC, 2011, BEHAV BRAIN RES, V219, P116, DOI 10.1016/j.bbr.2010.12.028
   Firlag M, 2013, FOLIA NEUROPATHOL, V51, P235, DOI 10.5114/fn.2013.37708
   Flachs P, 2014, PHYSIOL RES, V63, pS93, DOI 10.33549/physiolres.932715
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   Fredersdorf S, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-57
   Gadgil MD, 2013, DIABETES CARE, V36, P1132, DOI 10.2337/dc12-0869
   Gamoh S, 2001, CLIN EXP PHARMACOL P, V28, P266, DOI 10.1046/j.1440-1681.2001.03437.x
   Gatineau E, 2015, J NUTR, V145, P923, DOI 10.3945/jn.114.205583
   Geijselaers SLC, 2015, LANCET DIABETES ENDO, V3, P75, DOI 10.1016/S2213-8587(14)70148-2
   Guglielmotto M, 2012, NEUROBIOL AGING, V33, DOI 10.1016/j.neurobiolaging.2010.05.026
   Hashimoto M, 2005, J NUTR, V135, P549, DOI 10.1093/jn/135.3.549
   Hashimoto M., 2014, BIOCHIM BIOPHYS ACTA, V1851, P203
   Hill Cristal M, 2015, Age (Dordr), V37, P9765, DOI 10.1007/s11357-015-9765-1
   Huang SY, 2008, J PSYCHIATR RES, V42, P58, DOI 10.1016/j.jpsychires.2006.09.004
   Hudson BI, 2011, ATHEROSCLEROSIS, V216, P192, DOI 10.1016/j.atherosclerosis.2011.01.024
   Inestrosa NC, 2015, BRAIN PATHOL, V25, P679, DOI 10.1111/bpa.12226
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   Kamal A, 2000, DIABETOLOGIA, V43, P500, DOI 10.1007/s001250051335
   Keleshian VL, 2013, J NEUROCHEM, V125, P63, DOI 10.1111/jnc.12153
   Kotani S, 2006, NEUROSCI RES, V56, P159, DOI 10.1016/j.neures.2006.06.010
   Lands B, 2014, PROG LIPID RES, V55, P17, DOI 10.1016/j.plipres.2014.04.002
   Latour A, 2013, AGING CELL, V12, P76, DOI 10.1111/acel.12026
   Lautt WW, 2011, CAN J PHYSIOL PHARM, V89, P135, DOI [10.1139/Y11-001, 10.1139/y11-001]
   Layé S, 2010, PROSTAG LEUKOTR ESS, V82, P295, DOI 10.1016/j.plefa.2010.02.006
   Lee HC, 2015, J FUNCT FOODS, V19, P929, DOI 10.1016/j.jff.2015.01.040
   Lee HC, 2014, FOOD FUNCT, V5, P990, DOI 10.1039/c3fo60717h
   Lei C, 2015, NEUROSCIENCE, V295, P39, DOI 10.1016/j.neuroscience.2015.03.032
   Li RL, 2013, J SURG RES, V185, P815, DOI 10.1016/j.jss.2013.06.043
   Lin PY, 2012, J CLIN PSYCHIAT, V73, P1245, DOI 10.4088/JCP.11r07546
   Lin YH, 2012, LIPIDS, V47, P527, DOI 10.1007/s11745-012-3661-6
   Little SJ, 2007, PROSTAG LEUKOTR ESS, V77, P155, DOI 10.1016/j.plefa.2007.08.009
   Londero LG, 2013, CELL BIOCHEM FUNCT, V31, P636, DOI 10.1002/cbf.2947
   Luchtman DW, 2013, NEUROPHARMACOLOGY, V64, P550, DOI 10.1016/j.neuropharm.2012.07.019
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   MAES M, 1990, BIOL PSYCHIAT, V27, P854, DOI 10.1016/0006-3223(90)90466-F
   Masoodi M, 2015, BBA-MOL CELL BIOL L, V1851, P503, DOI 10.1016/j.bbalip.2014.09.023
   Massiera F, 2010, J LIPID RES, V51, P2352, DOI 10.1194/jlr.M006866
   McNamara RK, 2010, PROSTAG LEUKOTR ESS, V83, P185, DOI 10.1016/j.plefa.2010.08.004
   Mingam R, 2008, EUR J NEUROSCI, V28, P1877, DOI 10.1111/j.1460-9568.2008.06470.x
   Mitchell SJ, 2015, ANNU REV ANIM BIOSCI, V3, P283, DOI 10.1146/annurev-animal-022114-110829
   Momma H, 2014, J CLIN ENDOCR METAB, V99, P587, DOI 10.1210/jc.2013-2936
   Moranis A, 2012, BRAIN BEHAV IMMUN, V26, P721, DOI 10.1016/j.bbi.2011.11.001
   MORRIS RGM, 1982, NATURE, V297, P681, DOI 10.1038/297681a0
   Nunes S, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-44
   Perez-Martinez P, 2013, CLIN NUTR, V32, P630, DOI 10.1016/j.clnu.2012.10.003
   Phuwamongkolwiwat P, 2014, EUR J NUTR, V53, P457, DOI 10.1007/s00394-013-0546-2
   PORSOLT RD, 1977, NATURE, V266, P730, DOI 10.1038/266730a0
   Poudyal H, 2011, PROG LIPID RES, V50, P372, DOI 10.1016/j.plipres.2011.06.003
   Rao JS, 2007, MOL PSYCHIATR, V12, P151, DOI 10.1038/sj.mp.4001887
   Rethorst CD, 2014, J CLIN PSYCHIAT, V75, pE1428, DOI 10.4088/JCP.14m09009
   Ribeiro R, 2005, DIABETOLOGIA, V48, P976, DOI 10.1007/s00125-005-1714-6
   Romanatto T, 2014, BBA-MOL BASIS DIS, V1842, P186, DOI 10.1016/j.bbadis.2013.10.017
   Roriz JS, 2009, BBA-MOL BASIS DIS, V1792, P432, DOI 10.1016/j.bbadis.2008.12.003
   Samuelsson AM, 2013, FRONT PHYSIOL, V4, DOI 10.3389/fphys.2013.00014
   Simopoulos AP, 2006, BIOMED PHARMACOTHER, V60, P502, DOI 10.1016/j.biopha.2006.07.080
   Singh-Manoux A, 2012, NEUROLOGY, V79, P755, DOI 10.1212/WNL.0b013e3182661f63
   Soares E, 2013, NEUROSCIENCE, V250, P565, DOI 10.1016/j.neuroscience.2013.07.055
   Song C, 2004, J LIPID RES, V45, P1112, DOI 10.1194/jlr.M300526-JLr200
   Soria A, 2001, J APPL PHYSIOL, V91, P2109, DOI 10.1152/jappl.2001.91.5.2109
   Su KP, 2003, EUR NEUROPSYCHOPHARM, V13, P267, DOI 10.1016/S0924-977X(03)00032-4
   Tan ZS, 2011, DIABETES CARE, V34, P1766, DOI 10.2337/dc11-0308
   Taylor JR, 2013, AM J HEALTH-SYST PH, V70, P320, DOI 10.2146/ajhp110381
   van Praag H, 2005, J NEUROSCI, V25, P8680, DOI 10.1523/JNEUROSCI.1731-05.2005
   Venna VR, 2009, PSYCHONEUROENDOCRINO, V34, P199, DOI 10.1016/j.psyneuen.2008.08.025
   Wang MY, 2009, ACTA NEUROPATHOL, V118, P381, DOI 10.1007/s00401-009-0513-4
   Wei W, 2012, J NUTR BIOCHEM, V23, P1333, DOI 10.1016/j.jnutbio.2011.08.002
   Yates CM, 2014, PHARMACOL THERAPEUT, V141, P272, DOI 10.1016/j.pharmthera.2013.10.010
   Yates KF, 2012, ARTERIOSCL THROM VAS, V32, P2060, DOI 10.1161/ATVBAHA.112.252759
   Yau JLW, 2012, FRONT AGING NEUROSCI, V4, DOI 10.3389/fnagi.2012.00024
   Zhang T, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-15
NR 91
TC 3
Z9 3
U1 1
U2 13
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD DEC
PY 2015
VL 19
BP 522
EP 536
DI 10.1016/j.jff.2015.09.050
PN A
PG 15
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA CX3XZ
UT WOS:000365634100049
OA hybrid
DA 2025-06-11
ER

PT J
AU Ramanathan, V
   Raj, DA
   Thekkumalai, M
AF Ramanathan, Veerappan
   Raj, Dominic Amal
   Thekkumalai, Malarvili
TI Macrotyloma uniflorum (Lam.) Verdc. improves glucose metabolism
   and proinflammatory parameters in high fructose fed rats
SO INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY
LA English
DT Article
DE Adiponectin; Fructose diet; Glucocorticoid; Horsegram; Insulin
   resistance; Leptin; Mitochondrial enzymes
ID INSULIN-RESISTANCE SYNDROME; ADIPONECTIN; ANTIOXIDANT; EXPRESSION;
   AUTOPHAGY; ETIOLOGY; LEPTIN
AB Diabetes mellitus (DM) is the most common chronic metabolic disease and its complications constitute major health problems in heart, kidneys, eyes and nerves. The high fructose fed diet (HFFD) induces insulin resistance (IR), hyperinsulinaemia, hyperglycemia, alterations in lipid metabolism, and oxidative stress which plays a vital role in pathology associated with insulin resistance. Here, we explored the possible role of common pulse, horsegram (Macrotyloma uniflorum) as a therapeutic adjunct in a metabolic state of insulin resistance. Male adult Wistar strain albino rats (160-180 g) were divided into four groups of six rats in each. It is observed that the levels of Corticosterone (GC) and protein-bound sugars were higher and activities of liver mitochondrial enzymes were altered in HFFD rats, as compared to control animals. With the administered with M. uniflorum as adjunct in treatment of IR treatment which are functioned by increased GC in liver and adipose tissue and by stimulated liver mitochondrial enzymes activities and IR with reduce fructose.
C1 [Ramanathan, Veerappan] Enathi Rajappa Arts & Sci Coll, Dept Biochem, Pattukkottai, Tamil Nadu, India.
   [Raj, Dominic Amal] Adavan Arts & Sci Coll, Dept Biochem, Tiruchirappalli, Tamil Nadu, India.
   [Thekkumalai, Malarvili] Bharathidasan Univ, Constituents Coll, Thanjavur, Tamil Nadu, India.
C3 Bharathidasan University
RP Thekkumalai, M (corresponding author), Bharathidasan Univ, Constituents Coll, Thanjavur, Tamil Nadu, India.
EM drrmveera@gmail.com
RI Thekkumalai, Malarvili/CAJ-1151-2022
CR Aba PE, 2018, INDIAN J NAT PROD RE, V9, P85
   Äijälä M, 2013, GENES NUTR, V8, P623, DOI 10.1007/s12263-013-0357-3
   Ainscow EK, 2000, DIABETES, V49, P1149, DOI 10.2337/diabetes.49.7.1149
   [Anonymous], 2019, Classification of diabetes mellitus
   [Anonymous], 2002, Biochemistry: International Version
   Basciano Heather, 2005, Nutr Metab (Lond), V2, P5, DOI 10.1186/1743-7075-2-5
   Di Dalmazi G, 2012, EUR J ENDOCRINOL, V166, P669, DOI 10.1530/EJE-11-1039
   Durga KK, 2012, J ARID LAND, V4, P71, DOI 10.3724/SP.J.1227.2012.00071
   Giribabu N, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/542026
   Gupta A, 2018, INDIAN J EXP BIOL, V56, P598
   International Diabetes Federation, 2017, IDF Diabetes Atlas, V8th
   Iwasaki Y, 2008, MOL CELL ENDOCRINOL, V285, P10, DOI 10.1016/j.mce.2008.01.012
   Jayanthi M, 2012, INT J PHARM SCI RES, V3, P600, DOI 10.13040/IJPSR.0975-8232.3(2).600-04
   Kaundal SP, 2019, INT J PHARM SCI RES, V10, P3178, DOI 10.13040/IJPSR.0975-8232.10(7).3178-86
   Kelley GL, 2004, ENDOCRINOLOGY, V145, P548, DOI 10.1210/en.2003-1167
   Kumar A, 2017, INDIAN J EXP BIOL, V55, P63
   Kushwaha V, 2017, INDIAN J TRADIT KNOW, V16, P40
   Lazar MA, 2006, NAT MED, V12, P43, DOI 10.1038/nm0106-43
   Liang Y, 2005, METABOLISM, V54, P848, DOI 10.1016/j.metabol.2005.01.030
   Mahfouz M. H., 2010, American Journal of Biochemistry and Biotechnology, V6, P11
   Malik SA, 2011, CELL CYCLE, V10, P2917, DOI 10.4161/cc.10.17.17067
   Miller A, 2008, CURR OPIN GASTROEN, V24, P204, DOI 10.1097/MOG.0b013e3282f3f4c4
   Navarro JF, 2006, AM J NEPHROL, V26, P562, DOI 10.1159/000098004
   Parmar H B, 2012, Int J Pharmacol Res, V2, P86
   Petersen KF, 2006, AM J MED, V119, p10S, DOI 10.1016/j.amjmed.2006.01.009
   Priyadarshini E, 2017, CAN J DIABETES, V41, P41, DOI 10.1016/j.jcjd.2016.06.003
   Ramalingam M, 2014, J RECEPT SIG TRANSD, V34, P212, DOI 10.3109/10799893.2013.876043
   Rao PV, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/486047
   Reaven GM, 2005, ANNU REV NUTR, V25, P391, DOI 10.1146/annurev.nutr.24.012003.132155
   Reddy SR, 2012, IRAN J PHARM RES, V11, P277
   Reddy SS, 2009, FOOD CHEM TOXICOL, V47, P2224, DOI 10.1016/j.fct.2009.06.008
   Saravanan N, 2017, INDIAN J EXP BIOL, V55, P142
   Semchyshyn HM, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/343914
   Sharma R, 2017, INDIAN J EXP BIOL, V55, P611
   Sjöholm Å, 2006, DIABETES-METAB RES, V22, P4, DOI 10.1002/dmrr.568
   Stanhope KL, 2009, J CLIN INVEST, V119, P1322, DOI 10.1172/JCI37385
   Steinberger J, 2003, OBES RES, V11, P1124, DOI 10.1038/oby.2003.153
   Teff KL, 2016, J CLIN ENDOCR METAB, V89, P2963
   Turer AT, 2012, DIABETOLOGIA, V55, P2319, DOI 10.1007/s00125-012-2598-x
   Vaiopoulos AG, 2012, INT J CARDIOL, V155, P188, DOI 10.1016/j.ijcard.2011.07.047
   van Raalte DH, 2009, EUR J CLIN INVEST, V39, P81, DOI 10.1111/j.1365-2362.2008.02067.x
   Veerappan RM, 2018, INT J PHARM DRUG ANA, V6, P262
NR 42
TC 1
Z9 1
U1 0
U2 0
PU NATL INST SCIENCE COMMUNICATION-NISCAIR
PI NEW DELHI
PA DR K S KRISHNAN MARG, PUSA CAMPUS, NEW DELHI 110 012, INDIA
SN 0019-5189
EI 0975-1009
J9 INDIAN J EXP BIOL
JI Indian J. Exp. Biol.
PD AUG
PY 2019
VL 57
IS 8
BP 594
EP 601
PG 8
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA JF8WU
UT WOS:000491665600005
DA 2025-06-11
ER

PT J
AU Abaj, F
   Esmaeily, Z
   Naeini, Z
   Rafiee, M
   Koohdani, F
AF Abaj, Faezeh
   Esmaeily, Zahra
   Naeini, Zeinab
   Rafiee, Masoumeh
   Koohdani, Fariba
TI Dietary acid load modifies the effects of ApoA2-265 T > C polymorphism
   on lipid profile and serum leptin and ghrelin levels among type 2
   diabetic patients
SO BMC ENDOCRINE DISORDERS
LA English
DT Article
DE APOA2-265 T > C polymorphism; T2DM; Nutrigenetic; Dietary acid load
ID APOLIPOPROTEIN-A-II; BODY-MASS INDEX; CARDIOMETABOLIC RISK-FACTORS;
   METABOLIC SYNDROME; REACTIVE PROTEIN; OXIDATIVE STRESS; FATTY-ACIDS;
   TRANSGENIC MICE; FOOD-INTAKE; BASE LOAD
AB This investigation with aimed the effect of APOA2-265 T > C polymorphism and dietary acid load (DAL) as either potential renal acid load (PRAL) and net endogenous acid production (NEAP) intake interaction on metabolic markers in type 2 diabetes mellitus (T2DM). In present cross-sectional study, 737 patients with T2DM (290 men and 447 women) were enlisted from diabetes centers in Tehran. The dietary intakes of all participants during the last year was acquired by a validated semi-quantitative food frequency (FFQ) questionnaire. Polymerase chain reaction (PCR) was used for genotyping the APOA2-265 T > C. Biochemical indises containing leptin, ghrelin, total cholesterol (Bailey et al., J Clin Invest 97:1147-1453, 1996), low-density lipoprotein cholestrol (LDL-C), high-density lipoprotein cholestrol (HDL-C), triglyceride (TG), superoxide dismutase (SOD), high sensitivy C-reactive protein (hs-CRP), total antioxidant capacity (TAC), pentraxin-3 (PTX3), prostaglandin F2 alpha (PGF2 alpha) and interleukin 18 (IL18) were measured by standard method. Atherogenic indices (AIP, AC, CR-I, CR-II) were calculated. The gene-diet interactions were evaluated using an GLM. The frequency overall prevalence of rs5082 genotypes was 63.82 and 36.17% for T-allele and C-allele respectively. TG, Ghrelin, and hs-CRP concentrations were significantly higher among carriers with C allele than TT homozygotes. However, TC/CC genotypes have lower PTX3 than TT homozygotes (P < 0.05). C-allele carriers had highest mean of BMI (P(NEAP=)0.04, P-PRAL = 0.006), WC (P(NEAP=)0.04, P-PRAL = 0.04), TC (P(NEAP=)0.03, P-PRAL = 0.01), ghrelin (P(NEAP=)0.01, P-PRAL = 0.04), and leptin (P(NEAP=)0.04, P-PRAL = 0.03) when placed in top tertiles of NEAP and PRAL.BMI, WC, TC, ghrelin, and leptin levels may be modified in C carriers by decreasing DAL, though, further investigations are required to confirm these findings.
C1 [Abaj, Faezeh; Esmaeily, Zahra] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Naeini, Zeinab; Koohdani, Fariba] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Cellular & Mol Nutr, POB 141556117, Tehran, Iran.
   [Rafiee, Masoumeh] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Esfahan, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Isfahan University of Medical Sciences
RP Koohdani, F (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Cellular & Mol Nutr, POB 141556117, Tehran, Iran.; Rafiee, M (corresponding author), Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Esfahan, Iran.
EM masomeh.rafiei@gmail.com; fkoohdan@tums.ac.ir
RI Abaj, Faezeh/ABA-8101-2021; Koohdani, Fariba/D-1298-2018; Rafiee,
   Masoumeh/AAC-8806-2019
OI Esmaeily, Zahra/0000-0003-0353-4457; Abaj, Faezeh/0000-0002-7841-2000
FU Tehran University of Medical Sciences [15061]
FX This work was supported by the Tehran University of Medical Sciences
   [grant number 15061].
CR Abaj F, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-98663-9
   Abaj F, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-95359-y
   Abshirini M, 2019, DIABETOL METAB SYNDR, V11, DOI 10.1186/s13098-019-0447-5
   Adamska-Patruno E, 2019, NUTRIENTS, V11, DOI 10.3390/nu11030493
   Alvandi E, 2014, J DIABETES METAB DIS, V13, DOI 10.1186/2251-6581-13-26
   Ambrosini GL, 2010, NUTR METAB CARDIOVAS, V20, P274, DOI 10.1016/j.numecd.2009.03.024
   [Anonymous], 2012, SULTAN QABOOS U MED, DOI DOI 10.12816/0003082
   Arisawa K, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061605
   Asghar A, 2017, CELL IMMUNOL, V315, P18, DOI 10.1016/j.cellimm.2017.03.001
   Azad BJ, 2021, J NUTR SCI, V10, DOI 10.1017/jns.2020.61
   Babio N, 2012, NUTR METAB CARDIOVAS, V22, P200, DOI 10.1016/j.numecd.2010.06.011
   Bahadoran Z, 2015, ENDOCRINOL METAB, V30, P201, DOI 10.3803/EnM.2015.30.2.201
   Bailey JL, 1996, J CLIN INVEST, V97, P1447, DOI 10.1172/JCI118566
   Basiri MG, 2015, GENES NUTR, V10, DOI 10.1007/s12263-015-0464-4
   Birjmohun RS, 2007, CIRCULATION, V116, P2029, DOI 10.1161/CIRCULATIONAHA.107.704031
   Boisfer E, 1999, J BIOL CHEM, V274, P11564, DOI 10.1074/jbc.274.17.11564
   Cauci S, 2021, MOLECULES, V26, DOI 10.3390/molecules26041070
   Chen SW, 2019, CLIN NUTR ESPEN, V33, P171, DOI 10.1016/j.clnesp.2019.05.020
   Simao ANC, 2010, ARQ BRAS ENDOCRINOL, V54, P463, DOI 10.1590/S0004-27302010000500006
   Corella D, 2011, INT J OBESITY, V35, P666, DOI 10.1038/ijo.2010.187
   Corella D, 2007, CLIN CHEM, V53, P1144, DOI 10.1373/clinchem.2006.084863
   Corella D, 2009, ARCH INTERN MED, V169, P1897, DOI 10.1001/archinternmed.2009.343
   Cottone S, 2006, AM J HYPERTENS, V19, P313, DOI 10.1016/j.amjhyper.2005.09.005
   Daneshzad E, 2019, PUBLIC HEALTH NUTR, V22, P2823, DOI 10.1017/S1368980019001125
   Domínguez-Reyes T, 2015, LIPIDS HEALTH DIS, V14, DOI 10.1186/s12944-015-0112-4
   Duesing K, 2009, BMC MED GENET, V10, DOI 10.1186/1471-2350-10-13
   Eckstein P., 2011, The Science Journal of the Lander College of Arts and Sciences, V4, P7
   Emamat Hadi, 2019, Recent Pat Food Nutr Agric, V10, P27, DOI 10.2174/2212798410666180924142222
   Escolà-Gil JC, 2001, J LIPID RES, V42, P241
   Esmaillzadeh A, 2005, EUR J CLIN NUTR, V59, P353, DOI 10.1038/sj.ejcn.1602080
   Esteghamati A, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-13379-z
   Farhangi MA, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0216547
   Fatahi S., 2019, J Gorgan Univ Med Sci, V21, P76
   Frassetto LA, 1998, AM J CLIN NUTR, V68, P576, DOI 10.1093/ajcn/68.3.576
   Gaman MA, 2020, WORLD J DIABETES, V11, P193, DOI 10.4239/wjd.v11.i5.193
   Gargari BP, 2015, INT J FERTIL STERIL, V9, P313
   Giacco F, 2010, CIRC RES, V107, P1058, DOI 10.1161/CIRCRESAHA.110.223545
   Giugliano D, 2006, J AM COLL CARDIOL, V48, P677, DOI 10.1016/j.jacc.2006.03.052
   Gogga P, 2019, ACTA BIOCHIM POL, V66, P77, DOI 10.18388/abp.2018_2725
   Hietavala EM, 2015, EUR J CLIN NUTR, V69, P399, DOI 10.1038/ejcn.2014.245
   Hribal ML, 2014, CURR PHARM DESIGN, V20, P609, DOI 10.2174/13816128113199990016
   Javardi MSM, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-01387-4
   Julve-Gil J, 1999, METABOLISM, V48, P415, DOI 10.1016/S0026-0495(99)90097-5
   Kelishadi R., 2004, J SHAHREKORD U MED S, V3, P55
   Keramat L, 2017, NUTRITION, V37, P86, DOI 10.1016/j.nut.2016.12.012
   Kido Y, 2017, DIABETOL INT, V8, P7, DOI 10.1007/s13340-016-0299-2
   Kiefte-de Jong JC, 2017, DIABETOLOGIA, V60, P270, DOI 10.1007/s00125-016-4153-7
   Kim Mi-Hyun, 2015, Clin Nutr Res, V4, P175, DOI 10.7762/cnr.2015.4.3.175
   Klok MD, 2007, OBES REV, V8, P21, DOI 10.1111/j.1467-789X.2006.00270.x
   Kong A, 2009, NUTR RES, V29, P768, DOI 10.1016/j.nutres.2009.10.013
   Krupp D, 2018, NUTRIENTS, V10, DOI 10.3390/nu10010103
   Kucharska AM, 2018, ADV CLIN EXP MED, V27, P1347, DOI 10.17219/acem/69733
   Lai CQ, 2018, AM J CLIN NUTR, V108, P188, DOI 10.1093/ajcn/nqy081
   Lee HY, 2000, EUR J CLIN NUTR, V54, P768, DOI 10.1038/sj.ejcn.1601089
   Leon BM, 2015, WORLD J DIABETES, V6, P1246, DOI 10.4239/wjd.v6.i13.1246
   Ley SH, 2014, AM J CLIN NUTR, V99, P352, DOI 10.3945/ajcn.113.075663
   Lin WT, 2020, INT J PUBLIC HEALTH, V65, P45, DOI 10.1007/s00038-020-01330-5
   Mazidi M, 2021, BRIT J NUTR, V125, P1043, DOI 10.1017/S0007114519002149
   McNaughton SA, 2008, J NUTR, V138, P364, DOI 10.1093/jn/138.2.364
   MILLER SA, 1988, NUCLEIC ACIDS RES, V16, P1215, DOI 10.1093/nar/16.3.1215
   Mirzababaei A, 2022, CLIN NUTR ESPEN, V47, P267, DOI 10.1016/j.clnesp.2021.11.033
   Moghadam Sajjad Khalili, 2016, Prev Nutr Food Sci, V21, P104
   Montonen J, 2013, EUR J NUTR, V52, P337, DOI 10.1007/s00394-012-0340-6
   Mozaffari H, 2019, NUTRITION, V67-68, DOI 10.1016/j.nut.2019.110570
   Murakami K, 2008, BRIT J NUTR, V100, P642, DOI 10.1017/S0007114508901288
   Murea Mariana, 2012, Rev Diabet Stud, V9, P6, DOI 10.1900/RDS.2012.9.6
   Naeini Z, 2020, NUTR METAB CARDIOVAS, V30, P441, DOI 10.1016/j.numecd.2019.10.012
   Noorshahi N, 2016, CLIN NUTR, V35, P907, DOI 10.1016/j.clnu.2015.06.008
   Olamoyegun MA, 2016, ANN AFR MED, V15, P194, DOI 10.4103/1596-3519.194280
   Onat A, 2009, CLIN CHEM LAB MED, V47, P1389, DOI 10.1515/CCLM.2009.310
   Organization WH, 2011, Waist Circumference and Waist-Hip Ratio: Report of a WHO Expert Consultation
   Ostrowska J, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113419
   Osuna-Padilla IA, 2019, NEFROLOGIA, V39, P343, DOI 10.1016/j.nefro.2018.10.005
   Perry CA, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.647847
   Polak AM, 2020, NUTRIENTS, V12, DOI 10.3390/nu12092753
   Prodam F, 2014, ARCH IMMUNOL THER EX, V62, P369, DOI 10.1007/s00005-014-0287-9
   Rebholz CM, 2015, AM J NEPHROL, V42, P427, DOI 10.1159/000443746
   Remer T, 2003, AM J CLIN NUTR, V77, P1255, DOI 10.1093/ajcn/77.5.1255
   Saraf-Bank S, 2018, CLIN NUTR, V37, P2054, DOI 10.1016/j.clnu.2017.09.020
   Smith CE, 2012, INT J OBESITY, V36, P130, DOI 10.1038/ijo.2011.24
   Smith CE, 2013, J NUTR, V143, P1865, DOI 10.3945/jn.113.179051
   Sotos-Prieto M, 2013, NUTR HOSP, V28, P999, DOI 10.3305/nh.2013.28.4.6475
   Sudhakar M, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01167
   Takada D, 2002, J HUM GENET, V47, P656, DOI 10.1007/s100380200101
   Tiwari Brahm Kumar, 2013, J Biomark, V2013, P378790, DOI 10.1155/2013/378790
   Tsalamandris S, 2019, EUR CARDIOL REV, V14, P50, DOI 10.15420/ecr.2018.33.1
   van't Hooft FM, 2001, CIRCULATION, V104, P1223, DOI 10.1161/hc3601.095709
   Weinhold B, 1997, BIOCHEM J, V327, P425, DOI 10.1042/bj3270425
   Willett WC, 1997, AM J CLIN NUTR, V65, P1220, DOI 10.1093/ajcn/65.4.1220S
   Wright N, 2017, NUTR DIABETES, V7, DOI 10.1038/nutd.2017.3
   Wu TY, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081913
   Yang QH, 2014, JAMA INTERN MED, V174, P516, DOI 10.1001/jamainternmed.2013.13563
   Yi DW, 2012, DIABETES METAB J, V36, P56, DOI 10.4093/dmj.2012.36.1.56
   Zaki ME, 2013, CHOLESTEROL, DOI 10.1155/2013/289481
   Zaki ME, 2014, META GENE, V2, P366, DOI 10.1016/j.mgene.2014.04.007
   Zlibut A, 2019, ADV CLIN CHEM, V91, P163, DOI 10.1016/bs.acc.2019.03.005
NR 96
TC 4
Z9 4
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6823
J9 BMC ENDOCR DISORD
JI BMC Endocr. Disord.
PD JUL 26
PY 2022
VL 22
IS 1
AR 190
DI 10.1186/s12902-022-01083-7
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 3F5PP
UT WOS:000830721400001
PM 35883173
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Miedlich, SU
   Lamberti, JS
AF Miedlich, Susanne U.
   Lamberti, J. Steven
TI Connecting the dots: Understanding and addressing the metabolic impact
   of antipsychotic and antidepressant medications
SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
LA English
DT Review
DE antidepressant medications; antipsychotic medications; diabetes
   mellitus; effectiveness; mechanism of action; metabolic side effects;
   metabolic syndrome; obesity; psychotropic medications
ID MAJOR DEPRESSIVE DISORDER; LIFE-STYLE INTERVENTIONS; INDUCED
   WEIGHT-GAIN; SERIOUS MENTAL-ILLNESS; SCHIZOPHRENIA SPECTRUM DISORDERS;
   DIABETES-MELLITUS; BIPOLAR DISORDER; DOUBLE-BLIND; GLUCOSE-HOMEOSTASIS;
   SMOKING-CESSATION
AB Serious mental disorders such as schizophrenia and major depression are associated with considerable morbidity and mortality, resulting in much shorter life expectancies in those affected. The discovery of antipsychotic medications ushered in improved health outcomes for people with serious mental disorders but also brought about increased morbidity due to their metabolic side effects, including obesity and diabetes mellitus. Antidepressant medications have a more favorable metabolic side effect profile, but some can still cause weight gain and hyperglycemia. In this narrative review, we discuss antipsychotic and antidepressant medications' mechanisms of action, their respective effectiveness in treating psychosis and depression, and their metabolic side effects. In addition, we present therapeutic strategies for minimizing cardiometabolic health risks in patients treated with these medications by applying a comprehensive, biopsychosocial approach.
C1 [Miedlich, Susanne U.] Univ Rochester, Div Endocrinol, Med Ctr, Dept Med, Rochester, NY 14642 USA.
   [Lamberti, J. Steven] Univ Rochester, Med Ctr, Dept Psychiat, Rochester, NY USA.
C3 University of Rochester; University of Rochester
RP Miedlich, SU (corresponding author), Univ Rochester, Div Endocrinol, Med Ctr, Dept Med, Rochester, NY 14642 USA.
EM susanne_miedlich@urmc.rochester.edu
FU University of Rochester Medical Center; Department of Medicine of the
   University of Rochester Medical Center
FX S.U.M. has been supported by an award from the Department of Medicine of
   the University of Rochester Medical Center.
CR Abdul-Ghani MA, 2015, AM J PHYSIOL-RENAL, V309, pF889, DOI 10.1152/ajprenal.00267.2015
   Abosi O, 2018, HORM MOL BIOL CLIN I, V36, DOI 10.1515/hmbci-2017-0065
   Acosta A, 2021, OBESITY, V29, P662, DOI 10.1002/oby.23120
   ADNITT PI, 1968, DIABETES, V17, P628, DOI 10.2337/diab.17.10.628
   Afzal M, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.769309
   Agarwal SM, 2023, SCHIZOPHRENIA BULL, V49, P833, DOI 10.1093/schbul/sbad037
   Alberti KG., 2009, Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
   Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   Angrist B M, 1970, Biol Psychiatry, V2, P95
   [Anonymous], 2024, DIABETES CARE, V47, pS179, DOI 10.2337/dc24-S010
   [Anonymous], 1964, ARCH GEN PSYCHIAT, V10, P246
   [Anonymous], 2022, National Survey on Drug Use and Health | CBHSQ Data
   Anthenelli RM, 2016, LANCET, V387, P2507, DOI 10.1016/S0140-6736(16)30272-0
   Anttila SAK, 2001, CNS DRUG REV, V7, P249
   Aringhieri S, 2018, PHARMACOL THERAPEUT, V192, P20, DOI 10.1016/j.pharmthera.2018.06.012
   ASHCROFT GW, 1966, LANCET, V2, P1049
   Ayyagari R, 2020, J MED ECON, V23, P204, DOI 10.1080/13696998.2019.1685818
   Bak M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094112
   Balasubramanyam A, 2008, ENDOCR REV, V29, P292, DOI 10.1210/er.2007-0026
   Banham L, 2010, ADDICTION, V105, P1176, DOI 10.1111/j.1360-0443.2010.02946.x
   Barak N, 2016, J CLIN PSYCHOPHARM, V36, P253, DOI 10.1097/JCP.0000000000000489
   Barry S, 2024, PSYCHIAT SERV, V75, P733, DOI 10.1176/appi.ps.20230226
   Bauer IE, 2016, J PSYCHIATR RES, V74, P1, DOI 10.1016/j.jpsychires.2015.12.006
   Baumeister H, 2014, DIABETIC MED, V31, P773, DOI 10.1111/dme.12452
   BELL DS, 1973, ARCH GEN PSYCHIAT, V29, P35
   Björkhem-Bergman L, 2011, J PSYCHOPHARMACOL, V25, P299, DOI 10.1177/0269881109353461
   Bonora BM, 2018, DIABETES OBES METAB, V20, P25, DOI 10.1111/dom.13012
   Boudieu L, 2023, PHARMACEUTICS, V15, DOI 10.3390/pharmaceutics15122773
   Bruning JC, 2023, SCIENCE, V381, P1426, DOI 10.1126/science.abl7398
   Bushe CJ, 2009, INT J CLIN PRACT, V63, P1743, DOI 10.1111/j.1742-1241.2009.02224.x
   Cabassa LJ, 2010, PSYCHIAT SERV, V61, P774, DOI 10.1176/ps.2010.61.8.774
   CANTU TG, 1988, DRUG INTEL CLIN PHAR, V22, P755, DOI 10.1177/106002808802201002
   Carli M, 2021, PHARMACEUTICALS-BASE, V14, DOI 10.3390/ph14030238
   CARLSSON A, 1963, ACTA PHARMACOL TOX, V20, P140
   Chang SC, 2021, WORLD J PSYCHIATR, V11, P696, DOI 10.5498/wjp.v11.i10.696
   Chireh B, 2019, PREV MED REP, V14, DOI 10.1016/j.pmedr.2019.100822
   COPPEN A, 1967, BRIT J PSYCHIAT, V113, P1237, DOI 10.1192/bjp.113.504.1237
   Correll CU, 2022, SCHIZOPHRENIA-UK, V8, DOI 10.1038/s41537-022-00320-1
   Correll CU, 2022, SCHIZOPHR RES, V250, P67, DOI 10.1016/j.schres.2022.10.019
   Correll CU, 2022, WORLD PSYCHIATRY, V21, P248, DOI 10.1002/wps.20994
   Correll CU, 2016, J CLIN PSYCHIAT, V77, pE746, DOI 10.4088/JCP.15r10373
   Costa GPA, 2024, DIABETES OBES METAB, V26, P2292, DOI 10.1111/dom.15543
   Cowie CC, 2010, DIABETES CARE, V33, P562, DOI 10.2337/dc09-1524
   Daumit GL, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.7247
   Daumit GL, 2013, NEW ENGL J MED, V368, P1594, DOI 10.1056/NEJMoa1214530
   Davies M, 2021, LANCET, V397, P971, DOI 10.1016/S0140-6736(21)00213-0
   Dayabandara M, 2017, NEUROPSYCH DIS TREAT, V13, DOI 10.2147/NDT.S113099
   Hert M, 2012, NAT REV ENDOCRINOL, V8, P114, DOI 10.1038/nrendo.2011.156
   de Leon J, 2005, SCHIZOPHR RES, V76, P135, DOI 10.1016/j.schres.2005.02.010
   de Silva VA, 2016, BMC PSYCHIATRY, V16, DOI 10.1186/s12888-016-1049-5
   DELAY J, 1952, Ann Med Psychol (Paris), V110, P112
   Delgado PL, 2000, J CLIN PSYCHIAT, V61, P7
   Derijks HJ, 2008, EUR J CLIN PHARMACOL, V64, P531, DOI 10.1007/s00228-007-0441-y
   Durell N, 2022, J PHARM TECHNOL, V38, P283, DOI 10.1177/87551225221110850
   Eckel RH, 2006, CIRCULATION, V113, P2943, DOI 10.1161/CIRCULATIONAHA.106.176583
   Ehret M, 2010, J CLIN PSYCHIAT, V71, P1286, DOI 10.4088/JCP.09m05274yel
   ElSayed NA, 2024, DIABETES CARE, V47, pS158, DOI 10.2337/dc24-S009
   Elsayed NA, 2024, DIABETES CARE, V47, pS219, DOI 10.2337/dc24-S011
   ElSayed NA, 2024, DIABETES CARE, V47, pS20, DOI 10.2337/dc24-S002
   Fernandes BS, 2022, NEUROSCI BIOBEHAV R, V139, DOI 10.1016/j.neubiorev.2022.104758
   Firth J, 2019, LANCET PSYCHIAT, V6, P890, DOI 10.1016/S2215-0366(19)30387-6
   Fisher L, 2019, DIABETIC MED, V36, P803, DOI 10.1111/dme.13967
   Fonseca M, 2023, J NEUROENDOCRINOL, V35, DOI 10.1111/jne.13347
   Foretz M, 2023, NAT REV ENDOCRINOL, V19, P460, DOI 10.1038/s41574-023-00833-4
   Fornaro M, 2022, NEUROSCI BIOBEHAV R, V132, P289, DOI 10.1016/j.neubiorev.2021.11.039
   Gadde Kishore M, 2007, Expert Rev Neurother, V7, P17, DOI 10.1586/14737175.7.1.17
   Gadde KM, 2006, J CLIN PSYCHOPHARM, V26, P409, DOI 10.1097/01.jcp.0000227354.54074.5d
   Gammon D, 2021, BIOMOLECULES, V11, DOI 10.3390/biom11071030
   Garrido-Torres N, 2021, PSYCHOL MED, V51, P2307, DOI 10.1017/S0033291721002853
   Ghanizadeh A, 2013, SCHIZOPHR RES, V147, P110, DOI 10.1016/j.schres.2013.03.021
   Gibson-Smith D, 2016, J CLIN PSYCHIAT, V77, pE144, DOI 10.4088/JCP.14m09658
   Gierisch JM, 2014, J CLIN PSYCHIAT, V75, pE424, DOI 10.4088/JCP.13r08558
   Gilbody S, 2021, BRIT J PSYCHIAT, V218, P95, DOI 10.1192/bjp.2019.192
   Gill H, 2020, OBESITY, V28, P2064, DOI 10.1002/oby.22969
   Goh KK, 2019, INT J PSYCHIAT CLIN, V23, P14, DOI 10.1080/13651501.2018.1449864
   Gonzalez C. L., 2021, Primary Care Companion for CNS Disorders, V23
   Graham EA, 2020, J AFFECT DISORDERS, V265, P224, DOI 10.1016/j.jad.2020.01.053
   Greenway FL, 2010, LANCET, V376, P595, DOI 10.1016/S0140-6736(10)60888-4
   Guina J, 2017, HUM PSYCHOPHARM CLIN, V32, DOI 10.1002/hup.2604
   Gumnick JF, 2000, J CLIN PSYCHIAT, V61, P5
   Haber R, 2024, DIABETES OBES METAB, V26, P1850, DOI 10.1111/dom.15501
   Hammoud R, 2023, NAT REV ENDOCRINOL, V19, P201, DOI 10.1038/s41574-022-00783-3
   Hawes MR, 2021, J DUAL DIAGN, V17, P216, DOI 10.1080/15504263.2021.1944712
   He M, 2014, PSYCHONEUROENDOCRINO, V42, P153, DOI 10.1016/j.psyneuen.2014.01.018
   He Q, 2024, SCHIZOPHR RES, V271, P371, DOI 10.1016/j.schres.2024.07.028
   Hennings JM, 2012, CURR PHARM DESIGN, V18, P5900
   Hertel P, 2006, SYNAPSE, V60, P543, DOI 10.1002/syn.20322
   HERTTING G, 1961, J PHARMACOL EXP THER, V134, P146
   Hirschfeld RMA, 2000, J CLIN PSYCHIAT, V61, P4
   Hu Y, 2024, EUR J CLIN INVEST, V54, DOI 10.1111/eci.14122
   Fernández-San-Martín MI, 2014, COMMUNITY MENT HLT J, V50, P81, DOI 10.1007/s10597-013-9614-6
   Ishoy PL, 2017, DIABETES OBES METAB, V19, P162, DOI 10.1111/dom.12795
   Iturralde E, 2021, GEN HOSP PSYCHIAT, V68, P1, DOI 10.1016/j.genhosppsych.2020.11.002
   Jastreboff AM, 2022, NEW ENGL J MED, V387, P205, DOI 10.1056/NEJMoa2206038
   Jawad MY, 2022, J AFFECT DISORDERS, V301, P99, DOI 10.1016/j.jad.2022.01.004
   Jiang WL, 2020, TRANSL PSYCHIAT, V10, DOI 10.1038/s41398-020-0785-y
   Jin HJ, 2023, BRIT J PSYCHIAT, V223, P362, DOI 10.1192/bjp.2023.52
   Kamath A, 2018, BIOMED RES INT, V2018, DOI 10.1155/2018/4907264
   KANE J, 1988, ARCH GEN PSYCHIAT, V45, P789
   Kaplan G, 2013, PATIENT PREFER ADHER, V7, P1171, DOI 10.2147/PPA.S53795
   Kaul I, 2024, LANCET, V403, P160, DOI 10.1016/S0140-6736(23)02190-6
   Kim SF, 2007, P NATL ACAD SCI USA, V104, P3456, DOI 10.1073/pnas.0611417104
   Kishi T, 2015, EUR ARCH PSY CLIN N, V265, P259, DOI 10.1007/s00406-014-0551-3
   Klausen MK, 2022, JCI INSIGHT, V7, DOI 10.1172/jci.insight.159863
   Klausen MK, 2022, BRIT J PHARMACOL, V179, P625, DOI 10.1111/bph.15677
   Larsen JR, 2017, JAMA PSYCHIAT, V74, P719, DOI 10.1001/jamapsychiatry.2017.1220
   Lee SH, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.25
   Lengsfeld S, 2023, ECLINICALMEDICINE, V57, DOI 10.1016/j.eclinm.2023.101865
   Leucht S, 2009, PSYCHOL MED, V39, P1591, DOI 10.1017/S0033291709005455
   Leucht S, 2012, LANCET, V379, P2063, DOI 10.1016/S0140-6736(12)60239-6
   Leucht S, 2009, LANCET, V373, P31, DOI 10.1016/S0140-6736(08)61764-X
   Lieberman J. A., 2020, The APA textbook of schizophrenia, V2nd ed.
   Lieberman JA, 2005, NEW ENGL J MED, V353, P1209, DOI 10.1056/NEJMoa051688
   Lieberman JA, 2006, PSYCHIAT SERV, V57, P1075, DOI 10.1176/appi.ps.57.8.1075
   Lieberman JA, 2011, AM J PSYCHIAT, V168, P770, DOI 10.1176/appi.ajp.2011.11010039
   López-Muñoz F, 2009, CURR PHARM DESIGN, V15, P1563, DOI 10.2174/138161209788168001
   Lord CC, 2017, J CLIN INVEST, V127, P3408, DOI 10.1172/JCI93362
   Mahmood S, 2013, J CLIN PSYCHOPHARM, V33, P90, DOI 10.1097/JCP.0b013e31827cb2b7
   Assuncao SSM, 2006, REV BRAS PSIQUIATR, V28, P270, DOI 10.1590/S1516-44462006005000007
   Matsui-Sakata Akiko, 2005, Drug Metab Pharmacokinet, V20, P368, DOI 10.2133/dmpk.20.368
   May P.R. A., 1968, Treatment of schizophrenia. A comparative study of five treatment methods
   MAY PRA, 1976, ARCH GEN PSYCHIAT, V33, P481
   MAY PRA, 1976, ARCH GEN PSYCHIAT, V33, P474
   Mazereel V, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.573479
   McElroy Susan L, 2013, Prim Care Companion CNS Disord, V15, DOI 10.4088/PCC.12m01494
   McElroy SL, 2012, J CLIN PSYCHOPHARM, V32, P165, DOI 10.1097/JCP.0b013e3182488758
   McIntyre RS, 2021, AM J PSYCHIAT, V178, P383, DOI 10.1176/appi.ajp.2020.20081251
   McIntyre RS, 2006, EXPERT OPIN DRUG SAF, V5, P157, DOI 10.1517/14740338.5.1.157
   Mehta VS, 2016, EARLY INTERV PSYCHIA, V10, P522, DOI 10.1111/eip.12205
   Meijnikman AS, 2017, INT J OBESITY, V41, P1615, DOI 10.1038/ijo.2017.165
   Miedlich SU, 2024, PLOS ONE, V19, DOI 10.1371/journal.pone.0306798
   Miola A, 2022, HUM PSYCHOPHARM CLIN, V37, DOI 10.1002/hup.2821
   Misiak B, 2020, SCHIZOPHR RES, V223, P2, DOI 10.1016/j.schres.2020.07.011
   Mitchell AJ, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0210674
   Mohanty K, 2024, J HEALTH PSYCHOL, V29, P690, DOI 10.1177/13591053241227384
   MONTAGU KA, 1957, NATURE, V180, P244, DOI 10.1038/180244a0
   Moulton CD, 2015, LANCET DIABETES ENDO, V3, P461, DOI 10.1016/S2213-8587(15)00134-5
   Mucheru Doreen, 2019, JBI Database System Rev Implement Rep, V17, P1770, DOI 10.11124/JBISRIR-2017-003943
   Mukherjee S, 2022, FRONT NUTR, V8, DOI 10.3389/fnut.2021.815456
   Nagata M, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-52590-y
   Naslund JA, 2017, GEN HOSP PSYCHIAT, V47, P83, DOI 10.1016/j.genhosppsych.2017.04.003
   Nemeroff CB, 2007, J CLIN PSYCHIAT, V68, P17
   Nihalani Nikhil D, 2007, Ann Clin Psychiatry, V19, P105, DOI 10.1080/10401230701338169
   Nilsson BM, 2006, J MED CHEM, V49, P4023, DOI 10.1021/jm058240i
   Noda K, 2022, DIABETOL INT, V13, P693, DOI 10.1007/s13340-022-00590-1
   O'Brien PL, 2017, PSYCHIAT SERV, V68, P549, DOI 10.1176/appi.ps.201500482
   Pae CU, 2003, HUM PSYCHOPHARM CLIN, V18, P453, DOI 10.1002/hup.507
   Pan A, 2012, DIABETOLOGIA, V55, P63, DOI 10.1007/s00125-011-2268-4
   Pan A, 2012, INT J OBESITY, V36, P595, DOI 10.1038/ijo.2011.111
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pape LM, 2022, BMC PSYCHIATRY, V22, DOI 10.1186/s12888-022-03854-x
   Parker G, 2003, BRIT J PSYCHIAT, V183, P102, DOI 10.1192/bjp.183.2.102
   Pearsall R, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-027389
   Peckham E, 2017, BMC PSYCHIATRY, V17, DOI 10.1186/s12888-017-1419-7
   Pereira VS, 2018, ACTA NEUROPSYCHIATR, V30, P307, DOI 10.1017/neu.2017.39
   Perlis L.T., 2020, Prim. Care Companion CNS Disord., V22
   Pigott HE, 2010, PSYCHOTHER PSYCHOSOM, V79, P267, DOI 10.1159/000318293
   Pillinger T, 2023, LANCET PSYCHIAT, V10, P860, DOI 10.1016/S2215-0366(23)00262-6
   Pillinger T, 2023, PSYCHOL MED, V53, P3150, DOI 10.1017/S0033291721005213
   Pillinger T, 2017, JAMA PSYCHIAT, V74, P261, DOI 10.1001/jamapsychiatry.2016.3803
   Polcwiartek C, 2017, DIABETOLOGIA, V60, P1678, DOI 10.1007/s00125-017-4320-5
   Poyurovsky M, 2005, INT CLIN PSYCHOPHARM, V20, P101, DOI 10.1097/00004850-200503000-00007
   Poyurovsky M, 2004, EUR NEUROPSYCHOPHARM, V14, P332
   Poyurovsky M, 2013, PSYCHOPHARMACOLOGY, V226, P615, DOI 10.1007/s00213-012-2935-2
   Prasad F, 2023, THER ADV PSYCHOPHARM, V13, DOI 10.1177/20451253231165169
   Przegalinski E, 2023, NUTRIENTS, V15, DOI 10.3390/nu15061449
   Rafizadeh R, 2023, J PSYCHOPHARMACOL, V37, P135, DOI 10.1177/02698811221142575
   Reif A, 2023, NEW ENGL J MED, V389, P1298, DOI 10.1056/NEJMoa2304145
   Rivera FB, 2024, AM J PREVENT CARDIOL, V18, DOI 10.1016/j.ajpc.2024.100679
   Roberts E, 2016, ADDICTION, V111, P599, DOI 10.1111/add.13236
   Robinson DS, 2008, J AFFECT DISORDERS, V105, P15, DOI 10.1016/j.jad.2007.04.024
   Rotella F, 2013, DIABETES RES CLIN PR, V99, P98, DOI 10.1016/j.diabres.2012.11.022
   Rotella F, 2013, J CLIN PSYCHIAT, V74, P32, DOI 10.4088/JCP.12r07922
   Rubin RR, 2008, DIABETES CARE, V31, P420, DOI 10.2337/dc07-1827
   Rush AJ, 2006, AM J PSYCHIAT, V163, P1905, DOI 10.1176/appi.ajp.163.11.1905
   Salvi V, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0182088
   Schernthaner G, 2020, DIABETES RES CLIN PR, V159, DOI 10.1016/j.diabres.2019.107946
   Schöttl SE, 2022, BMC SPORTS SCI MED R, V14, DOI 10.1186/s13102-022-00498-y
   Schreiber Matthew A, 2019, Prim Care Companion CNS Disord, V21, DOI 10.4088/PCC.18r02324
   SEEMAN P, 1975, SCIENCE, V188, P1217, DOI 10.1126/science.1145194
   SEEMAN P, 1976, NATURE, V261, P717, DOI 10.1038/261717a0
   Serretti A, 2010, J CLIN PSYCHIAT, V71, P1259, DOI 10.4088/JCP.09r05346blu
   Sharma R, 2016, LANCET RESP MED, V4, P835, DOI 10.1016/S2213-2600(16)30228-4
   Silvestre JS, 2005, METHOD FIND EXP CLIN, V27, P289, DOI 10.1358/mf.2005.27.5.908643
   Singh VK, 2018, SCHIZOPHR RES, V202, P17, DOI 10.1016/j.schres.2018.06.066
   Siskind D, 2021, SCHIZOPHRENIA BULL, V47, P948, DOI 10.1093/schbul/sbaa191
   Siskind DJ, 2020, LANCET PSYCHIAT, V7, P762, DOI 10.1016/S2215-0366(20)30261-3
   Siskind DJ, 2018, DIABETES OBES METAB, V20, P1050, DOI 10.1111/dom.13167
   Smith Kerri, 2014, Nature, V515, P181, DOI 10.1038/515180a
   Smith M, 2008, BRIT J PSYCHIAT, V192, P406, DOI 10.1192/bjp.bp.107.037184
   Smith RC, 2018, PSYCHOPHARMACOLOGY, V235, P3545, DOI 10.1007/s00213-018-5079-1
   Solmi M, 2024, EXPERT OPIN DRUG SAF, V23, P1249, DOI 10.1080/14740338.2024.2396396
   Solmi M, 2023, MOL PSYCHIATR, V28, P5319, DOI 10.1038/s41380-023-02138-4
   Solmi M, 2022, EUR NEUROPSYCHOPHARM, V62, P1, DOI 10.1016/j.euroneuro.2022.05.014
   Solmi M, 2022, SCHIZOPHRENIA BULL, V48, P166, DOI 10.1093/schbul/sbab087
   Spanakis P, 2022, ADDICTION, V117, P1526, DOI 10.1111/add.15724
   Speyer H, 2019, PSYCHOTHER PSYCHOSOM, V88, P350, DOI 10.1159/000502293
   Srisurapanont M, 2022, NEUROSCI BIOBEHAV R, V139, DOI 10.1016/j.neubiorev.2022.104731
   Stachowicz K, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.988648
   Stogios N, 2023, CURR PSYCHIAT REP, V25, P707, DOI 10.1007/s11920-023-01458-0
   Straub SG, 2012, AM J PHYSIOL-CELL PH, V302, pC1687, DOI 10.1152/ajpcell.00282.2011
   Stroup TS, 2013, SCHIZOPHR RES, V146, P190, DOI 10.1016/j.schres.2013.01.013
   Taub S, 2020, EUR NEUROPSYCHOPHARM, V41, P63, DOI 10.1016/j.euroneuro.2020.09.002
   Teasdale SB, 2019, BRIT J PSYCHIAT, V214, P251, DOI 10.1192/bjp.2019.20
   Teasdale SB, 2017, BRIT J PSYCHIAT, V210, P110, DOI 10.1192/bjp.bp.115.177139
   Thase Michael E, 2008, Curr Psychiatry Rep, V10, P487
   Tourian K.A., 2010, Primary care companion to the Journal of clinical psychiatry, V12
   Triggle CR, 2022, METABOLISM, V133, DOI 10.1016/j.metabol.2022.155223
   Trott M, 2024, CURR OPIN PSYCHIATR, V37, P363, DOI 10.1097/YCO.0000000000000952
   Tsoi DT, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007253.pub3
   Üstün TB, 2004, BRIT J PSYCHIAT, V184, P386, DOI 10.1192/bjp.184.5.386
   Vallis M, 2016, INT J CLIN PRACT, V70, P196, DOI 10.1111/ijcp.12765
   van der Meer RM, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006102.pub2
   van Galen KA, 2021, OBES REV, V22, DOI 10.1111/obr.13210
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vancampfort D, 2019, WORLD PSYCHIATRY, V18, P53, DOI 10.1002/wps.20614
   Vancampfort D, 2017, WORLD PSYCHIATRY, V16, P308, DOI 10.1002/wps.20458
   Vancampfort D, 2016, WORLD PSYCHIATRY, V15, P166, DOI 10.1002/wps.20309
   Vancampfort D, 2015, DEPRESS ANXIETY, V32, P763, DOI 10.1002/da.22387
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vandenberghe F, 2015, J CLIN PSYCHIAT, V76, pE1417, DOI 10.4088/JCP.14m09358
   VANPRAAG HM, 1965, PSYCHOPHARMACOLOGIA, V8, P67, DOI 10.1007/BF00405362
   VANROSSUM JM, 1966, ARCH INT PHARMACOD T, V160, P492
   Vermeulen JM, 2019, SCHIZOPHRENIA BULL, V45, P315, DOI 10.1093/schbul/sby052
   Volkow ND, 2011, TRENDS COGN SCI, V15, P37, DOI 10.1016/j.tics.2010.11.001
   Walker ER, 2015, JAMA PSYCHIAT, V72, P334, DOI 10.1001/jamapsychiatry.2014.2502
   Wallace TJM, 2011, PHARMACOGEN PERS MED, V4, P83, DOI 10.2147/PGPM.S11866
   Wang YQ, 2021, J AFFECT DISORDERS, V287, P41, DOI 10.1016/j.jad.2021.03.023
   Watanabe N, 2011, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006528.pub2
   Wen FK, 2020, CAN FAM PHYSICIAN, V66, P898, DOI 10.46747/cfp.6612898
   Whicher CA, 2021, DIABETES OBES METAB, V23, P1262, DOI 10.1111/dom.14334
   Wise RA, 2006, PHILOS T R SOC B, V361, P1149, DOI 10.1098/rstb.2006.1854
   Wium-Andersen IK, 2022, BASIC CLIN PHARMACOL, V131, P372, DOI 10.1111/bcpt.13776
   Wu Q, 2016, ADDICTION, V111, P1554, DOI 10.1111/add.13415
   Yammine L, 2021, NICOTINE TOB RES, V23, P1682, DOI 10.1093/ntr/ntab066
   Ye Z, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0021551
   ZELLER EA, 1952, J LAB CLIN MED, V40, P965
   Zeng LN, 2020, ASIAN J PSYCHIATR, V54, DOI 10.1016/j.ajp.2020.102190
   Zhang L, 2022, WORLD J CLIN CASES, V10, P7495, DOI 10.12998/wjcc.v10.i21.7495
   Zhang ZZ, 2022, ASIAN J PSYCHIATR, V73, DOI 10.1016/j.ajp.2022.103092
   Zheng W, 2016, ACTA PSYCHIAT SCAND, V134, P385, DOI 10.1111/acps.12631
   Zheng W, 2019, PHARMACOPSYCHIATRY, V52, P24, DOI 10.1055/s-0044-101466
   Zheng W, 2015, J CLIN PSYCHOPHARM, V35, P499, DOI 10.1097/JCP.0000000000000392
NR 243
TC 0
Z9 0
U1 4
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0077-8923
EI 1749-6632
J9 ANN NY ACAD SCI
JI Ann. N.Y. Acad. Sci.
PD APR
PY 2025
VL 1546
IS 1
BP 35
EP 57
DI 10.1111/nyas.15301
EA MAR 2025
PG 23
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 1KK9X
UT WOS:001442466500001
PM 40072935
DA 2025-06-11
ER

PT J
AU Marcate-Chénard, A
   Deshayes, TA
   Ghachem, A
   Brochu, M
AF Marcate-Chenard, Alexis
   Deshayes, Thomas A.
   Ghachem, Ahmed
   Brochu, Martin
TI Prevalence of the metabolic syndrome between 1999 and 2014 in the United
   States adult population and the impact of the 2007-2008 recession: an
   NHANES study
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE metabolic syndrome; waist circumference; dietary intake; recession;
   hypertension; dyslipidemia
ID NUTRITION EXAMINATION SURVEY; 3RD NATIONAL-HEALTH; US ADULTS; ABDOMINAL
   OBESITY; PHYSICAL-ACTIVITY; CARDIOVASCULAR-DISEASE; TRENDS; RISK;
   GLUCOSE; ANXIETY
AB To document changes in prevalence of the metabolic syndrome (MetS) in the United States adult population between 1999 and 2014 and to explore how variations in the dietary intakes explain changes in MetS prevalence and its components over time. A total of 38 541 individuals (aged 20-85 years; National Health and Nutrition Examination Survey 1999-2014) were studied. Outcome variables were MetS, waist circumference (WC), plasma high-density lipoprotein cholesterol (HDL-c), triglycerides, fasting glucose (FG) levels, resting systolic and diastolic blood pressure, dietary intakes (total daily energy, carbohydrates, proteins, fats, sodium, and alcohol intakes), the poverty income ratio (PIR) and sociodemographic data (age, sex, ethnicity). Overall, the prevalence of the MetS significantly increased between 1999 and 2014 (27.9% to 31.5%). High plasma FG levels and high WC increased between 1999 and 2014, while the prevalence of the other components of MetS decreased or remained stable. Interestingly, a significant peak in MetS prevalence was observed in 2007-2008 compared with 1999-2006 (34.4% vs 27.6%), accompanied by a concomitant increase in WC and plasma FG levels, as well as a decrease in plasma HDL-c. Finally, significant decreases were observed for the PIR, total daily energy intake, sodium, and all macronutrient intakes in 2007-2008 compared with 1999-2006 (all P < 0.01). Results showed that the MetS prevalence significantly increased between 1999 and 2014 in the United States adult population, with a peak in 2007-2008. Interestingly, the 2007-2008 peak in MetS prevalence was accompanied by decreases in the PIR, total daily energy, and macronutrients intakes, suggesting potential impact of the 2007-2008 recession.
C1 [Marcate-Chenard, Alexis; Deshayes, Thomas A.; Ghachem, Ahmed; Brochu, Martin] Univ Sherbrooke, Fac Phys Act Sci, Sherbrooke, PQ J1K 2R1, Canada.
   [Marcate-Chenard, Alexis; Deshayes, Thomas A.; Ghachem, Ahmed; Brochu, Martin] Univ Inst Geriatr Sherbrooke, Social Serv & Hlth Ctr, Res Ctr Aging, Sherbrooke, PQ J1H 4C4, Canada.
C3 University of Sherbrooke; University of Sherbrooke
RP Brochu, M (corresponding author), Univ Sherbrooke, Fac Phys Act Sci, Sherbrooke, PQ J1K 2R1, Canada.; Brochu, M (corresponding author), Univ Inst Geriatr Sherbrooke, Social Serv & Hlth Ctr, Res Ctr Aging, Sherbrooke, PQ J1H 4C4, Canada.
EM Martin.brochu@usherbrooke.ca
RI Deshayes, Thomas/HKO-7594-2023
OI Deshayes, Thomas/0000-0002-7620-1939
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Andersen CJ, 2013, REV ENDOCR METAB DIS, V14, P241, DOI 10.1007/s11154-013-9251-y
   [Anonymous], 2019, National Health and Nutrition Examination Survey
   [Anonymous], 2017, National Diabetes Statistics Report
   Arnett DK, 2005, CIRCULATION, V112, P3884, DOI 10.1161/CIRCULATIONAHA.105.549857
   Bano G, 2013, BEST PRACT RES CL OB, V27, P715, DOI 10.1016/j.bpobgyn.2013.02.007
   Beltrán-Sánchez H, 2013, J AM COLL CARDIOL, V62, P697, DOI 10.1016/j.jacc.2013.05.064
   Benjamin EJ, 2018, CIRCULATION, V137, pE67, DOI [10.1161/CIR.0000000000000485, 10.1161/CIR.0000000000000558, 10.1161/CIR.0000000000000530]
   Colman G, 2013, SOC SCI MED, V93, P11, DOI 10.1016/j.socscimed.2013.05.032
   Cooper Brian, 2011, Neuropsychiatr, V25, P113
   Després JP, 2008, ARTERIOSCL THROM VAS, V28, P1039, DOI 10.1161/ATVBAHA.107.159228
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Edwardson CL, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034916
   Flegal KM, 2010, JAMA-J AM MED ASSOC, V303, P235, DOI 10.1001/jama.2009.2014
   Flegal KM, 1998, INT J OBESITY, V22, P39, DOI 10.1038/sj.ijo.0800541
   Ford ES, 2010, INT J CARDIOL, V140, P226, DOI 10.1016/j.ijcard.2008.11.033
   Ford ES, 2005, OBES RES, V13, P608, DOI 10.1038/oby.2005.65
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Griffith R., 2013, I FISCAL STUDIES, V4, DOI [10.1920/BN.IFS.2012.00143, DOI 10.1920/BN.IFS.2012.00143]
   Healy GN, 2008, DIABETES CARE, V31, P369, DOI 10.2337/dc07-1795
   JAMES GD, 1986, PSYCHOSOM MED, V48, P502, DOI 10.1097/00006842-198609000-00005
   JAMES GD, 1993, AM J HYPERTENS, V6, pS170, DOI 10.1093/ajh/6.6.170S
   Kantor ED, 2015, JAMA-J AM MED ASSOC, V314, P1818, DOI 10.1001/jama.2015.13766
   Katikireddi SV, 2012, BMJ OPEN, V2, DOI 10.1136/bmjopen-2012-001790
   Kirkpatrick SI, 2012, J ACAD NUTR DIET, V112, P624, DOI 10.1016/j.jand.2011.11.012
   Lee K, 2012, PUBLIC HEALTH NUTR, V15, P1917, DOI 10.1017/S136898001100365X
   Leung CW, 2012, AM J CLIN NUTR, V96, P977, DOI 10.3945/ajcn.112.040014
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Misra A, 2008, J CLIN ENDOCR METAB, V93, pS9, DOI 10.1210/jc.2008-1595
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   Mozumdar A, 2011, DIABETES CARE, V34, P216, DOI 10.2337/dc10-0879
   Muzio F, 2007, AM J CLIN NUTR, V86, P946, DOI 10.1093/ajcn/86.4.946
   Oh SW, 2011, DIABETES METAB J, V35, P561, DOI 10.4093/dmj.2011.35.6.561
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Sarebanhassanabadi M, 2018, PUBLIC HEALTH NUTR, V21, P1139, DOI [10.1017/S1368980017003627, 10.1017/s1368980017003627]
   Sisson SB, 2009, METAB SYNDR RELAT D, V7, P529, DOI 10.1089/met.2009.0023
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   St-Pierre J, 2002, AM J CARDIOL, V90, P15, DOI 10.1016/S0002-9149(02)02378-0
   Todd J., 2014, LESS EATING OUT IMPR
   Vadiveloo M, 2015, J NUTR, V145, P564, DOI 10.3945/jn.114.199125
   World Health Organization, 2000, World Health Organ Tech Rep Ser, DOI DOI 10.1596/0-1952-1129-4
NR 43
TC 26
Z9 27
U1 0
U2 1
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD AUG
PY 2019
VL 44
IS 8
BP 861
EP 868
DI 10.1139/apnm-2018-0648
PG 8
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA IM4CX
UT WOS:000477943400009
PM 30640516
DA 2025-06-11
ER

PT J
AU Xu, DR
   Gao, X
   Zhao, LB
   Liu, SD
   Tang, G
   Zhou, CJ
   Chen, Y
AF Xu, Di-Ru
   Gao, Xi
   Zhao, Li-Bo
   Liu, Shu-Dong
   Tang, Ge
   Zhou, Chan-Juan
   Chen, Yu
TI Association between triglyceride and depression: A systematic review and
   meta-analysis
SO PLOS ONE
LA English
DT Review
ID SERUM-LIPID CONCENTRATIONS; MAJOR DEPRESSION; CARDIOVASCULAR RISK;
   METABOLIC SYNDROME; CHOLESTEROL; DISORDER; WOMEN; PREVALENCE; MARKERS;
   HEALTH
AB Depression is accompanied by dyslipidemia, which may increase the risk of stroke and coronary heart disease. This study sought to quantitatively summarize the clinical data comparing peripheral blood triglyceride (TG) concentrations between patients with major depressive disorder (MDD) and healthy controls (HCs). Studies were searched in PubMed, EMBASE, PsycINFO, and Cochrane Databases up to March 2023. We also reviewed the reference lists of obtained articles. Mean (+/- SD) for TG concentrations were extracted, combined quantitatively using random-effects meta-analysis, and summarized as a standardized mean difference (SMD). Subgroup analysis and meta-regression was performed to explore the resource of heterogeneity. Thirty-eight studies measuring the concentrations of peripheral blood TG in 2604 patients with MDD and 3272 HCs were included. Meta-analysis results indicated that TG levels were significant higher in patients with MDD than in HCs (SMD = 0.31, 95% confidence interval [CI]: 0.16 to 0.46, Z(46) = 4.05, p < 0.01). Heterogeneity was detected (chi(2) = 269.97, p < 0.01, I-2 = 85%). Subgroup analysis demonstrated significant differences in TG levels between patients with MDD and HCs depended on age, body mass index and drug use (p < 0.05), but no differences between groups. Meta-regression also found no significant variables. TG level was significantly elevated in depression, which may explain the increased risk of cardiovascular and cerebrovascular events in depression.
C1 [Xu, Di-Ru; Gao, Xi] Chongqing Med Univ, Univ Town Hosp, Dept Dermatol, Chongqing, Peoples R China.
   [Zhao, Li-Bo; Liu, Shu-Dong; Tang, Ge] Chongqing Med Univ, Yongchuan Hosp, Dept Neurol, Chongqing, Peoples R China.
   [Zhao, Li-Bo; Liu, Shu-Dong; Tang, Ge; Zhou, Chan-Juan; Chen, Yu] Chongqing Key Lab Cerebrovasc Dis Res, Chongqing, Peoples R China.
   [Chen, Yu] Chongqing Med Univ, Dept Neurol, Bishan Hosp, Chongqing, Peoples R China.
C3 Chongqing Medical University; Chongqing Medical University; Chongqing
   Medical University
RP Chen, Y (corresponding author), Chongqing Key Lab Cerebrovasc Dis Res, Chongqing, Peoples R China.; Chen, Y (corresponding author), Chongqing Med Univ, Dept Neurol, Bishan Hosp, Chongqing, Peoples R China.
EM cheny@hospital.cqmu.edu.cn
RI Zhao, Libo/G-2421-2010
OI Chen, Yu/0000-0002-9682-4922
FU National Natural Science Foundation of China [81601207]
FX National Natural Science Foundation of China (Grant No. 81601207)/. The
   funder of <EM><STRONG> </STRONG></EM>Professor Li Bo Zhao had proofread
   the manuscript.
CR Aliyazicioglu R, 2011, TURK KLIN TIP BILIM, V31, P1065, DOI 10.5336/medsci.2010-20010
   Baghai TC, 2011, J CLIN PSYCHIAT, V72, P1242, DOI 10.4088/JCP.09m05895blu
   Berglund L, 2012, J CLIN ENDOCR METAB, V97, P2969, DOI 10.1210/jc.2011-3213
   Bilici M, 2001, J AFFECT DISORDERS, V64, P43, DOI 10.1016/S0165-0327(00)00199-3
   Cizza G, 2009, HORM METAB RES, V41, P641, DOI 10.1055/s-0029-1220717
   Das PP, 2010, WORLD J BIOL PSYCHIA, V11, P321, DOI [10.1080/15622970902960889, 10.3109/15622970902960889]
   DERSIMONIAN R, 1986, CONTROL CLIN TRIALS, V7, P177, DOI 10.1016/0197-2456(86)90046-2
   Dong JY, 2012, STROKE, V43, P32, DOI 10.1161/STROKEAHA.111.630871
   Druzhkova T, 2019, METAB BRAIN DIS, V34, P621, DOI 10.1007/s11011-018-0367-3
   Egeland GM, 2015, EUR J PREV CARDIOL, V22, P872, DOI 10.1177/2047487314535681
   Eidan AJ, 2019, J INTERF CYTOK RES, V39, P181, DOI 10.1089/jir.2018.0134
   Gowey MA, 2019, INT J OBESITY, V43, P615, DOI 10.1038/s41366-018-0270-3
   Higgins JPT, 2003, BMJ-BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557
   Ho RCM, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15102073
   Honkalampi K, 2021, J PSYCHOSOM RES, V143, DOI 10.1016/j.jpsychores.2021.110389
   Huang TL, 2005, J AFFECT DISORDERS, V86, P75, DOI 10.1016/j.jad.2004.11.005
   Huang TL, 2004, PSYCHIAT CLIN NEUROS, V58, P295, DOI 10.1111/j.1440-1819.2004.01235.x
   Huang TL, 2003, PSYCHIAT RES, V118, P147, DOI 10.1016/S0165-1781(03)00071-4
   Hummel J, 2011, J CLIN PSYCHIAT, V72, P885, DOI 10.4088/JCP.09m05853blu
   Kamagate A, 2008, CELL CYCLE, V7, P3162, DOI 10.4161/cc.7.20.6882
   Kessler RC, 2007, WORLD PSYCHIATRY, V6, P168
   Khalid A, 1998, Indian J Psychiatry, V40, P217
   Kuehl LK, 2015, PSYCHONEUROENDOCRINO, V51, P365, DOI 10.1016/j.psyneuen.2014.09.012
   Kupfer DJ, 2012, LANCET, V379, P1045, DOI 10.1016/S0140-6736(11)60602-8
   Lamers F, 2013, MOL PSYCHIATR, V18, P692, DOI 10.1038/mp.2012.144
   Lehto SM, 2010, PSYCHIAT CLIN NEUROS, V64, P279, DOI 10.1111/j.1440-1819.2010.02079.x
   Lemche AV, 2017, J ENDOCRINOL INVEST, V40, P539, DOI 10.1007/s40618-016-0601-y
   Liu XY, 2016, ANAL BIOANAL CHEM, V408, P6497, DOI 10.1007/s00216-016-9768-5
   Liu YH, 2021, BMC PSYCHIATRY, V21, DOI 10.1186/s12888-021-03270-7
   Ljubicic R, 2013, COLLEGIUM ANTROPOL, V37, P1065
   Maes M, 1997, ACTA PSYCHIAT SCAND, V95, P212, DOI 10.1111/j.1600-0447.1997.tb09622.x
   Mashele N, 2013, CLIN EXP HYPERTENS, V35, P213, DOI 10.3109/10641963.2012.721837
   Muhtz C, 2009, PSYCHONEUROENDOCRINO, V34, P1004, DOI 10.1016/j.psyneuen.2009.01.016
   Nordestgaard BG, 2014, LANCET, V384, P626, DOI 10.1016/S0140-6736(14)61177-6
   Olusi SO, 1996, BIOL PSYCHIAT, V40, P1128, DOI 10.1016/S0006-3223(95)00599-4
   Pan JX, 2018, TRANSL PSYCHIAT, V8, DOI 10.1038/s41398-018-0183-x
   Péterfalvi A, 2019, FRONT PSYCHOL, V10, DOI 10.3389/fpsyg.2019.01798
   Politi P, 2008, ARCH MED RES, V39, P242, DOI 10.1016/j.arcmed.2007.07.011
   Rosenson RS, 2014, J AM COLL CARDIOL, V64, P2525, DOI 10.1016/j.jacc.2014.09.042
   Sagud M, 2009, PSYCHIAT RES, V168, P218, DOI 10.1016/j.psychres.2008.06.048
   Sánchez-Carro Y, 2023, PROG NEURO-PSYCHOPH, V121, DOI 10.1016/j.pnpbp.2022.110674
   Sarandol A, 2006, PROG NEURO-PSYCHOPH, V30, P1103, DOI 10.1016/j.pnpbp.2006.04.012
   Segoviano-Mendoza M, 2018, BMC PSYCHIATRY, V18, DOI 10.1186/s12888-018-1596-z
   Sevincok L, 2001, CAN J PSYCHIAT, V46, P68, DOI 10.1177/070674370104600110
   Silic A, 2022, ACTA NEUROPSYCHIATR, V34, P15, DOI 10.1017/neu.2021.30
   Simmons WK, 2016, AM J PSYCHIAT, V173, P418, DOI 10.1176/appi.ajp.2015.15020162
   Skibinska M, 2018, NORD J PSYCHIAT, V72, P191, DOI 10.1080/08039488.2017.1415373
   Sun LL, 2019, NAT MED, V25, P569, DOI 10.1038/s41591-019-0366-x
   Tabas I, 2007, CIRCULATION, V116, P1832, DOI 10.1161/CIRCULATIONAHA.106.676890
   Tenenbaum A, 2014, CARDIOVASC DIABETOL, V13, DOI 10.1186/s12933-014-0159-y
   Usalp S, 2023, CARDIOVASC J AFR, DOI 10.5830/CVJA-2023-038
   van Marwijk HWJ, 2015, BMC CARDIOVASC DISOR, V15, DOI 10.1186/s12872-015-0036-y
   Wagner CJ, 2019, PROG NEURO-PSYCHOPH, V92, P405, DOI 10.1016/j.pnpbp.2019.01.010
   Waloszek JM, 2015, J AFFECT DISORDERS, V175, P403, DOI 10.1016/j.jad.2015.01.008
   Wang G., 2003, Medical Journal of Wuhan University, P24
   Wingenfeld K, 2017, J PSYCHIATR RES, V95, P60, DOI 10.1016/j.jpsychires.2017.07.028
   Yang R, 2022, WORLD J BIOL PSYCHIA, V23, P228, DOI 10.1080/15622975.2021.1961500
   Zhang C, 2020, J PSYCHIATR RES, V130, P9, DOI 10.1016/j.jpsychires.2020.07.012
   Zhou XY, 2019, MOL PSYCHIATR, V24, P1478, DOI 10.1038/s41380-018-0047-z
NR 59
TC 2
Z9 2
U1 8
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 4
PY 2024
VL 19
IS 10
AR e0311625
DI 10.1371/journal.pone.0311625
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA I3N6T
UT WOS:001329362000042
PM 39365811
OA gold
DA 2025-06-11
ER

PT J
AU Oldenburg, J
AF Oldenburg, Jan
TI Hypogonadism and fertility issues following primary treatment or
   testicular cancer
SO UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
LA English
DT Review
DE Hypogonadism; Testosterone; Infertility; Testicular cancer;
   Subfertility; Cryopreservation; Accelerated ageing
ID LONG-TERM SURVIVORS; METABOLIC SYNDROME; SEXUAL FUNCTION;
   HORMONE-LEVELS; MEN; SPERMATOGENESIS; ORCHIECTOMY; INFERTILITY;
   POPULATION; RISK
AB Background: The majority of testicular cancer (TC) patients are cured and expected to live for decades after treatment, such that knowledge about hypogonadism and fertility issues is particularly important for the group of testicular cancer survivors (TCSs). Hypogonadism and fertility issues are related to treatment intensity.
   Methods: In order to give an overview about hypogonadism in testicular cancer survivors (TCSs) the literature was reviewed. Testicular dysfunction was defined as inadequate spemiatogenesis, as reflected by increased levels of Follicle Stimulating Hormone (FSH) and reduced fertility and/with or without insufficient testosterone (T) production with or without compensatory increased Luteinizing Hormone (LH) levels.
   Findings: Hypogonadism may lead to reduced sexual functioning and well-being, fertility problems, muscle weakness, loss of energy, and depression. Furthermore, hypogonadism also increases the risk of osteoporosis and is associated with the metabolic syndrome and cardiovascular disease (CVD). The hypothesized "Testicular Dysgenesis Syndrome" comprising low sperm counts, hypospadias, cryptorchidism, and finally TC, probably contributes to hypogonadism independent of applied TC treatment. Recently, an increased risk of accelerated hormonal ageing has been reported in TCSs in the very long term, i.e. 20 years after TC treatment. (C) 2015 Elsevier Inc. All rights reserved.
C1 Hgsk Buskerud & Vestfold, Hlth Sci, Kongsberg, Norway.
RP Oldenburg, J (corresponding author), Hgsk Buskerud & Vestfold, Hlth Sci, Kongsberg, Norway.
EM jan.oldenburg@medisin.uio.no
CR Andersen AG, 2000, HUM REPROD, V15, P366, DOI 10.1093/humrep/15.2.366
   Bandak M, 2011, EUR J CANCER, V47, P2585, DOI 10.1016/j.ejca.2011.05.026
   Basaria S, 2014, LANCET, V383, P1250, DOI 10.1016/S0140-6736(13)61126-5
   BERTHELSEN JG, 1987, INT J ANDROL, V10, P371, DOI 10.1111/j.1365-2605.1987.tb00205.x
   Bjerner J, 2009, SCAND J CLIN LAB INV, V69, P873, DOI 10.3109/00365510903380886
   Brydoy M, 2005, JNCI-J NATL CANCER I, V97, P1580, DOI 10.1093/jnci/dji339
   Brydoy M, 2012, BRIT J CANCER, V107, P1833, DOI 10.1038/bjc.2012.471
   Dahl AA, 2007, EUR UROL, V52, P1438, DOI 10.1016/j.eururo.2007.02.046
   Dohle GR, 2003, WORLD J UROL, V21, P341, DOI 10.1007/s00345-003-0365-9
   Eberhard J, 2009, J SEX MED, V6, P1979, DOI 10.1111/j.1743-6109.2009.01298.x
   FOSSA SD, 1984, EUR UROL, V10, P173
   Haugnes HS, 2007, ANN ONCOL, V18, P241, DOI 10.1093/annonc/mdl372
   Haugnes HS, 2012, J CLIN ONCOL, V30, P3752, DOI 10.1200/JCO.2012.43.4431
   Haugnes HS, 2010, J CLIN ONCOL, V28, P4649, DOI 10.1200/JCO.2010.29.9362
   Jacobsen R, 2000, BMJ-BRIT MED J, V321, P789, DOI 10.1136/bmj.321.7264.789
   Juul A, 2014, NAT REV ENDOCRINOL, V10, P553, DOI 10.1038/nrendo.2014.97
   Lampe H, 1997, J CLIN ONCOL, V15, P239, DOI 10.1200/JCO.1997.15.1.239
   Meachem SJ, 2001, EUR J ENDOCRINOL, V145, P561, DOI 10.1530/eje.0.1450561
   Nord C, 2003, EUR UROL, V44, P322, DOI 10.1016/S0302-2838(03)00263-X
   Nuver J, 2005, J CLIN ONCOL, V23, P3718, DOI 10.1200/JCO.2005.02.176
   Oldenburg J, 2013, ANN ONCOL, V24, P125, DOI 10.1093/annonc/mdt304
   Perheentupa A, 2009, MOL CELL ENDOCRINOL, V299, P2, DOI 10.1016/j.mce.2008.11.004
   Raman JD, 2005, J UROLOGY, V174, P1819, DOI 10.1097/01.ju.0000177491.98461.aa
   Skakkebek NE, 2007, INT J ANDROL, V30, P198, DOI 10.1111/j.1365-2605.2007.00776.x
   Skakkebæk NE, 2001, HUM REPROD, V16, P972, DOI 10.1093/humrep/16.5.972
   Sprauten M, 2014, J CLIN ONCOL, V32, P571, DOI 10.1200/JCO.2013.51.2715
NR 26
TC 15
Z9 15
U1 0
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1078-1439
EI 1873-2496
J9 UROL ONCOL-SEMIN ORI
JI Urol. Oncol.-Semin. Orig. Investig.
PD SEP
PY 2015
VL 33
IS 9
BP 407
EP 412
DI 10.1016/j.urolonc.2015.01.014
PG 6
WC Oncology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Urology & Nephrology
GA CR0TV
UT WOS:000361037000026
PM 25736189
DA 2025-06-11
ER

PT J
AU Schmitz, N
   Deschênes, SS
   Burns, RJ
   Danna, SM
   Franco, OH
   Ikram, MA
   Kivimäki, M
   Singh-Manoux, A
   Tiemeier, H
AF Schmitz, Norbert
   Deschenes, Sonya S.
   Burns, Rachel J.
   Danna, Sofia M.
   Franco, Oscar H.
   Ikram, M. Arfan
   Kivimaki, Mika
   Singh-Manoux, Archana
   Tiemeier, Henning
TI Cardiometabolic dysregulation and cognitive decline: potential role of
   depressive symptoms
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Article
ID INCREASED RISK; METABOLIC SYNDROME; DEMENTIA; DISEASE; ASSOCIATION;
   DISORDERS; METAANALYSIS; COMPONENTS; AGE
AB Background
   Previous studies have examined associations of cardiometabolic factors with depression and cognition separately.
   Aims
   To determine if depressive symptoms mediate the association between cardiometabolic factors and cognitive decline in two community studies.
   Method
   Data for the analyses were drawn from the Rotterdam Study, the Netherlands (n = 2940) and the Whitehall II study, UK (n = 4469).
   Results
   Mediation analyses suggested a direct association between cardiometabolic factors and cognitive decline and an indirect association through depression: poorer cardiometabolic status at time 1 was associated with a higher level of depressive symptoms at time 2 (standardised regression coefficient 0.07 and 0.06, respectively), which, in turn, was associated with greater cognitive decline between time 2 and time 3 (standardised regression coefficient of -0.15 and -0.41, respectively).
   Conclusions
   Evidence from two independent cohort studies suggest an association between cardiometabolic dysregulation and cognitive decline and that depressive symptoms tend to precede this decline.
C1 [Schmitz, Norbert; Deschenes, Sonya S.; Burns, Rachel J.] McGill Univ, Dept Psychiat, Montreal, PQ, Canada.
   [Schmitz, Norbert; Deschenes, Sonya S.; Burns, Rachel J.] Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada.
   [Schmitz, Norbert] Montreal Diabet Res Ctr, Montreal, PQ, Canada.
   [Danna, Sofia M.] McGill Univ, Dept Epidemiol & Biostat, Montreal, PQ, Canada.
   [Franco, Oscar H.; Ikram, M. Arfan] Erasmus MC, Univ Med Ctr Rotterdam, Dept Epidemiol, Rotterdam, Netherlands.
   [Kivimaki, Mika; Singh-Manoux, Archana] UCL, Dept Epidemiol & Publ Hlth, London, England.
   [Singh-Manoux, Archana] Hop Paul Brousse, INSERM, Ctr Res Epidemiol & Populat Hlth, U1018, Villejuif, France.
   [Tiemeier, Henning] Erasmus MC, Univ Med Ctr Rotterdam, Dept Psychiat, Dept Epidemiol, Rotterdam, Netherlands.
   [Tiemeier, Henning] Erasmus MC, Univ Med Ctr Rotterdam, Dept Child & Adolescent Psychiat, Rotterdam, Netherlands.
C3 McGill University; Universite de Montreal; McGill University; Erasmus
   University Rotterdam; Erasmus MC; University of London; University
   College London; Universite Paris Saclay; Institut National de la Sante
   et de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris
   (APHP); Hopital Universitaire Paul-Brousse - APHP; Erasmus University
   Rotterdam; Erasmus MC; Erasmus University Rotterdam; Erasmus MC
RP Schmitz, N (corresponding author), McGill Univ, Douglas Mental Hlth Univ Inst, 6875 LaSalle Blvd, Montreal, PQ H4H 1R3, Canada.
EM norbert.schmitz@mcgill.ca
RI Franco, Óscar/ABE-2305-2020; Tiemeier, Henning/H-6534-2019; Ikram,
   M./AAM-5225-2021; Kivimaki, Mika/B-3607-2012; Schmitz,
   Norbert/AAH-3624-2020; Deschenes, Sonya/G-6341-2017; Danna,
   Sofia/AFR-2563-2022; Singh-Manoux, Archana/F-6804-2013; Schmitz,
   Norbert/A-5177-2010
OI Danna, Sofia/0000-0003-4861-8400; Franco, Oscar/0000-0002-4606-4929;
   Singh-Manoux, Archana/0000-0002-1244-5037; Kivimaki,
   Mika/0000-0002-4699-5627; Deschenes, Sonya/0000-0002-9258-0895; Schmitz,
   Norbert/0000-0001-7777-6323
FU Erasmus Medical Center, Rotterdam; Netherlands Organization for the
   Health Research and Development (ZonMw); Research Institute for Diseases
   in the Elderly (RIDE); Ministry of Education, Culture and Science;
   Ministry for Health, Welfare and Sports; European Commission (DG XII);
   Municipality of Rotterdam; Medical Research Council [K013351]; National
   Institute on Aging [AG13196]; National Heart Lung and Blood Institute
   [HL36310]; British Heart Foundation; Erasmus University, Rotterdam; ESRC
   [ES/J023299/1] Funding Source: UKRI; MRC [MR/K013351/1] Funding Source:
   UKRI
FX The Rotterdam Study is funded by the Erasmus Medical Center and Erasmus
   University, Rotterdam, the Netherlands Organization for the Health
   Research and Development (ZonMw), the Research Institute for Diseases in
   the Elderly (RIDE), the Ministry of Education, Culture and Science, the
   Ministry for Health, Welfare and Sports, the European Commission (DG
   XII), and the Municipality of Rotterdam. Continuing data collection on
   the Whitehall II study is funded by the Medical Research Council
   (K013351), National Institute on Aging (AG13196), National Heart Lung
   and Blood Institute (HL36310) and the British Heart Foundation. No
   funding was received to complete the analysis and interpretation of data
   for this paper. The funding agencies had no role in the design or
   conduct of the study, in the collection, management, analysis, or
   interpretation of the data, or in the preparation, review, or approval
   of the manuscript.
CR Akbaraly TN, 2010, DIABETES CARE, V33, P84, DOI 10.2337/dc09-1218
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   [Anonymous], 2012, MPLUS Users Guide
   Beekman ATF, 1997, PSYCHOL MED, V27, P231, DOI 10.1017/S0033291796003510
   Birns J, 2009, J HUM HYPERTENS, V23, P86, DOI 10.1038/jhh.2008.80
   BLEECKER ML, 1988, J CLIN PSYCHOL, V44, P403, DOI 10.1002/1097-4679(198805)44:3<403::AID-JCLP2270440315>3.0.CO;2-0
   Bollen K. A., 1989, STRUCTURAL EQUATIONS, DOI DOI 10.1002/9781118619179
   Bordier L, 2014, DIABETES METAB, V40, P331, DOI 10.1016/j.diabet.2014.02.002
   BORKOWSKI JG, 1967, NEUROPSYCHOLOGIA, V5, P135, DOI 10.1016/0028-3932(67)90015-2
   Danna SM, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0160809
   Dik MG, 2007, DIABETES CARE, V30, P2655, DOI 10.2337/dc06-1190
   Epel ES, 2009, HORM-INT J ENDOCRINO, V8, P7, DOI 10.14310/horm.2002.1217
   Heim AW., 1970, AH 4 group test of general Intelligence
   Hofman A, 2013, EUR J EPIDEMIOL, V28, P889, DOI 10.1007/s10654-013-9866-z
   Hoogendam YY, 2014, EUR J EPIDEMIOL, V29, P133, DOI 10.1007/s10654-014-9885-4
   HOUX PJ, 1993, EXP AGING RES, V19, P209, DOI 10.1080/03610739308253934
   Jacqmin-Gadda H, 2013, EUR J EPIDEMIOL, V28, P493, DOI 10.1007/s10654-013-9818-7
   Juster RP, 2010, NEUROSCI BIOBEHAV R, V35, P2, DOI 10.1016/j.neubiorev.2009.10.002
   Katon W, 2012, ARCH GEN PSYCHIAT, V69, P410, DOI 10.1001/archgenpsychiatry.2011.154
   Katon WJ, 2010, J GEN INTERN MED, V25, P423, DOI 10.1007/s11606-009-1248-6
   Koolhaas CM, 2016, AM J EPIDEMIOL, V183, P729, DOI 10.1093/aje/kwv244
   Kraemer HC, 2001, AM J PSYCHIAT, V158, P848, DOI 10.1176/appi.ajp.158.987.848
   Lesage A, 2015, EPIDEMIOL PSYCH SCI, V24, P309, DOI 10.1017/S2045796015000426
   Liu CS, 2014, CNS NEUROL DISORD-DR, V13, P1693
   Marmot M, 2005, INT J EPIDEMIOL, V34, P251, DOI 10.1093/ije/dyh372
   Marsh HW, 2004, STRUCT EQU MODELING, V11, P320, DOI 10.1207/s15328007sem1103_2
   McArdle JJ, 2009, ANNU REV PSYCHOL, V60, P577, DOI 10.1146/annurev.psych.60.110707.163612
   McEwen BS, 2003, BIOL PSYCHIAT, V54, P200, DOI 10.1016/S0006-3223(03)00177-X
   Mirza SS, 2016, LANCET PSYCHIAT, V3, P628, DOI 10.1016/S2215-0366(16)00097-3
   Musselman DL, 1998, ARCH GEN PSYCHIAT, V55, P580, DOI 10.1001/archpsyc.55.7.580
   Nicholson A, 2005, PSYCHOSOM MED, V67, P522, DOI 10.1097/01.psy.0000171159.86446.9e
   Ownby RL, 2006, ARCH GEN PSYCHIAT, V63, P530, DOI 10.1001/archpsyc.63.5.530
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Preacher KJ, 2008, BEHAV RES METHODS, V40, P879, DOI 10.3758/BRM.40.3.879
   Rock PL, 2014, PSYCHOL MED, V44, P2029, DOI 10.1017/S0033291713002535
   Singh-Manoux A, 2017, EUR HEART J, V38, P2612, DOI 10.1093/eurheartj/ehx208
   Sullivan MD, 2013, JAMA PSYCHIAT, V70, P1041, DOI 10.1001/jamapsychiatry.2013.1965
   Tegeler C, 2016, NEUROBIOL AGING, V38, P112, DOI 10.1016/j.neurobiolaging.2015.10.039
   Tiffin J, 1948, J APPL PSYCHOL, V32, P234, DOI 10.1037/h0061266
   Tuligenga RH, 2014, LANCET DIABETES ENDO, V2, P228, DOI 10.1016/S2213-8587(13)70192-X
   van Vliet P, 2012, J ALZHEIMERS DIS, V30, pS147, DOI 10.3233/JAD-2011-111028
   Vogelzangs N, 2014, NEUROPSYCHOPHARMACOL, V39, P1624, DOI 10.1038/npp.2014.9
   WELSH KA, 1994, NEUROLOGY, V44, P609, DOI 10.1212/WNL.44.4.609
   Whitmer RA, 2008, NEUROLOGY, V71, P1057, DOI 10.1212/01.wnl.0000306313.89165.ef
NR 44
TC 27
Z9 33
U1 1
U2 11
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1250
EI 1472-1465
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD FEB
PY 2018
VL 212
IS 2
BP 96
EP 102
DI 10.1192/bjp.2017.26
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FU7IA
UT WOS:000424024500007
PM 29436332
OA Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Floege, J
AF Floege, Juergen
TI Magnesium in CKD: more than a calcification inhibitor?
SO JOURNAL OF NEPHROLOGY
LA English
DT Review
DE Magnesium; Chronic kidney disease; Cardiovascular disease; Diabetes;
   Depression
ID CHRONIC KIDNEY-DISEASE; ISCHEMIC-HEART-DISEASE; VASCULAR SMOOTH-MUSCLE;
   CALCIUM ACETATE/MAGNESIUM CARBONATE; FIBROBLAST GROWTH FACTOR-23;
   INTIMA-MEDIA THICKNESS; STAGE RENAL-DISEASE; DIETARY MAGNESIUM; SERUM
   MAGNESIUM; CARDIOVASCULAR-DISEASE
AB Magnesium fulfils important roles in multiple physiological processes. Accordingly, a tight regulation of magnesium homeostasis is essential. Dysregulated magnesium serum levels, in particular hypomagnesaemia, are common in patients with chronic kidney disease (CKD) and have been associated with poor clinical outcomes. In cell culture studies as well as in clinical situations magnesium levels were associated with vascular calcification, cardiovascular disease and altered bone-mineral metabolism. Magnesium has also been linked to diseases such as metabolic syndrome, diabetes, hypertension, fatigue and depression, all of which are common in CKD. The present review summarizes and discusses the latest clinical data on the impact of magnesium and possible effects of higher levels on the health status of patients with CKD, including an outlook on the use of magnesium-based phosphate-binding agents in this context.
C1 Rhein Westfal TH Aachen, Div Nephrol & Clin Immunol, D-52057 Aachen, Germany.
C3 RWTH Aachen University
RP Floege, J (corresponding author), Rhein Westfal TH Aachen, Div Nephrol & Clin Immunol, Pauwelsstr 30, D-52057 Aachen, Germany.
EM juergen.floege@rwth-aachen.de
CR Abbott RD, 2003, AM J CARDIOL, V92, P665, DOI [10.1016/S0002-9149(03)00819-1, 10.1016/s0002-9149(03)00819-1]
   Al-Delaimy WK, 2004, J AM COLL NUTR, V23, P63, DOI 10.1080/07315724.2004.10719344
   ALTURA BM, 1987, CAN J PHYSIOL PHARM, V65, P729, DOI 10.1139/y87-120
   Alves SC, 2013, NEPHROL DIAL TRANSPL, V28, P910, DOI 10.1093/ndt/gfs268
   [Anonymous], 2012, Clin Kidney J, V5, pNP, DOI 10.1093/ndtplus/sfs035
   [Anonymous], ERA EDTA REG ANN REP
   Ascherio A, 1996, HYPERTENSION, V27, P1065, DOI 10.1161/01.HYP.27.5.1065
   ASCHERIO A, 1992, CIRCULATION, V86, P1475, DOI 10.1161/01.CIR.86.5.1475
   Barragán-Rodríguez L, 2008, MAGNESIUM RES, V21, P218
   Bonner A, 2008, J CLIN NURS, V17, P90, DOI 10.1111/j.1365-2702.2007.02042.x
   BROWN EM, 1991, PHYSIOL REV, V71, P371, DOI 10.1152/physrev.1991.71.2.371
   Covic A, 2013, NEPHROL DIAL TRANSPL, V28, P2383, DOI 10.1093/ndt/gft203
   COX IM, 1991, LANCET, V337, P757, DOI 10.1016/0140-6736(91)91371-Z
   Cunningham J, 2012, CLIN KIDNEY J, V5, P39, DOI 10.1093/ndtplus/sfr166
   de Francisco ALM, 2010, NEPHROL DIAL TRANSPL, V25, P3707, DOI 10.1093/ndt/gfq292
   De Schutter TM, 2013, KIDNEY INT, V83, P1109, DOI 10.1038/ki.2013.34
   Del Gobbo LC, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-23
   Deng XQ, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-187
   Dickinson HO, 2006, DATABASE SYST REV, V3, P1, DOI [10.1002/14651858.CD004639.pub2, DOI 10.1002/14651858.CD004639.PUB2]
   Dong JY, 2011, DIABETES CARE, V34, P2116, DOI 10.2337/dc11-0518
   Elwood PC, 1996, EUR J CLIN NUTR, V50, P694
   Escobedo LG, 1997, EPIDEMIOLOGY, V8, P175, DOI 10.1097/00001648-199703000-00009
   Fischer DC, 2012, CALCIFIED TISSUE INT, V90, P465, DOI 10.1007/s00223-012-9594-5
   Foley RN, 1998, J NEPHROL, V11, P239
   Ford ES, 1999, INT J EPIDEMIOL, V28, P645, DOI 10.1093/ije/28.4.645
   Fragoso A, 2014, CLIN KIDNEY J, V7, P161, DOI 10.1093/ckj/sfu003
   Guasch-Ferré M, 2014, J NUTR, V144, P55, DOI 10.3945/jn.113.183012
   Hedayati SS, 2012, KIDNEY INT, V81, P247, DOI 10.1038/ki.2011.358
   Holick MF, 2006, J CLIN INVEST, V116, P2062, DOI 10.1172/JCI29449
   Horigan Ann, 2012, Medsurg Nurs, V21, P158
   Huang JH, 2012, NUTR J, V11, DOI 10.1186/1475-2891-11-41
   Iguchi A, 2014, NEPHROLOGY, V19, P667, DOI 10.1111/nep.12287
   Ivanovski O, 2005, KIDNEY INT, V67, P2288, DOI 10.1111/j.1523-1755.2005.00332.x
   Joosten MM, 2013, AM J CLIN NUTR, V97, P1299, DOI 10.3945/ajcn.112.054114
   Joosten MM, 2013, HYPERTENSION, V61, P1161, DOI 10.1161/HYPERTENSIONAHA.113.01333
   Kanbay M, 2012, AM J NEPHROL, V36, P228, DOI 10.1159/000341868
   Kircelli F, 2012, NEPHROL DIAL TRANSPL, V27, P514, DOI 10.1093/ndt/gfr321
   Kumar R, 2011, J AM SOC NEPHROL, V22, P216, DOI 10.1681/ASN.2010020186
   Li XH, 2012, NEUROPSYCHOPHARMACOL, V37, P77, DOI 10.1038/npp.2011.198
   Liao FZ, 1998, AM HEART J, V136, P480, DOI 10.1016/S0002-8703(98)70224-8
   London GM, 2013, KIDNEY INT SUPPL, V3, P442, DOI 10.1038/kisup.2013.92
   Louvet L, 2013, NEPHROL DIAL TRANSPL, V28, P869, DOI 10.1093/ndt/gfs520
   Maduell F, 2012, NEPHROL DIAL TRANSPL, V27, P506
   Massy ZA, 2012, CLIN KIDNEY J, V5, P52, DOI 10.1093/ndtplus/sfr167
   Matsuzaki H, 2013, MAGNESIUM RES, V26, P18, DOI 10.1684/mrh.2013.0331
   de Oca AM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0089525
   Mortazavi M, 2013, EUR NEUROL, V69, P309, DOI 10.1159/000346427
   Murck H, 2013, J PSYCHIATR RES, V47, P955, DOI 10.1016/j.jpsychires.2013.02.015
   Nair AV, 2012, P NATL ACAD SCI USA, V109, P11324, DOI 10.1073/pnas.1113811109
   PAOLISSO G, 1989, DIABETES CARE, V12, P265, DOI 10.2337/diacare.12.4.265
   Peters F, 2001, Z Kardiol, V90 Suppl 3, P81
   Pham PCT, 2005, CLIN NEPHROL, V63, P429
   Pham PCT, 2007, CLIN J AM SOC NEPHRO, V2, P366, DOI 10.2215/CJN.02960906
   Poleszak E, 2004, PHARMACOL BIOCHEM BE, V78, P7, DOI 10.1016/j.pbb.2004.01.006
   Prabodh S, 2011, BIOL TRACE ELEM RES, V142, P29, DOI 10.1007/s12011-010-8750-x
   Qu XH, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057720
   Quinn SJ, 2013, AM J PHYSIOL-ENDOC M, V304, pE724, DOI 10.1152/ajpendo.00557.2012
   Risco F, 1992, Magnes Res, V5, P5
   Risco Felix, 1994, Magnesium Research, V7, P169
   Rodríguez-Morán M, 2003, DIABETES CARE, V26, P1147, DOI 10.2337/diacare.26.4.1147
   Rodríguez-Moran M, 2014, EUR J INTERN MED, V25, P128, DOI 10.1016/j.ejim.2013.08.706
   Rodríguez-Ortiz ME, 2014, NEPHROL DIAL TRANSPL, V29, P282, DOI 10.1093/ndt/gft400
   Rosanoff A, 2010, MAGNESIUM RES, V23, pS180, DOI 10.1684/mrh.2010.0223
   ROSLER A, 1973, LANCET, V1, P803
   RUDE RK, 1985, J CLIN ENDOCR METAB, V61, P933, DOI 10.1210/jcem-61-5-933
   Rude RK, 2009, J AM COLL NUTR, V28, P131, DOI 10.1080/07315724.2009.10719764
   Sakaguchi Y, 2014, KIDNEY INT, V85, P174, DOI 10.1038/ki.2013.327
   Sakaguchi Y, 2012, DIABETES CARE, V35, P1591, DOI 10.2337/dc12-0226
   Salem S, 2012, AM J NEPHROL, V35, P31, DOI 10.1159/000334742
   Sales CH, 2011, CLIN NUTR, V30, P359, DOI 10.1016/j.clnu.2010.12.011
   Schöttker B, 2013, AGEING RES REV, V12, P708, DOI 10.1016/j.arr.2012.02.004
   Shanahan CM, 2006, NEPHROL DIAL TRANSPL, V21, P1166, DOI 10.1093/ndt/gfl089
   Shechter Michael, 2003, Am J Cardiovasc Drugs, V3, P231, DOI 10.2165/00129784-200303040-00001
   Silva PA., 2014, J DIABETES METAB, V5, P1000347, DOI [10.4172/2155-6156.1000347, DOI 10.4172/2155-6156.1000347]
   Socala K, 2012, PHARMACOL REP, V64, P205
   Song YQ, 2006, AM J CARDIOL, V98, P1616, DOI 10.1016/j.amjcard.2006.07.040
   Song YQ, 2009, BMC MED GENET, V10, DOI 10.1186/1471-2350-10-4
   Song YQ, 2005, AM J CARDIOL, V96, P1135, DOI 10.1016/j.amjcard.2005.06.045
   Szewczyk B, 2008, PHARMACOL REP, V60, P588
   Turgut F, 2008, INT UROL NEPHROL, V40, P1075, DOI 10.1007/s11255-008-9410-3
   Tyson KL, 2003, ARTERIOSCL THROM VAS, V23, P489, DOI 10.1161/01.ATV.0000059406.92165.31
   Van Laecke S, 2013, AM J MED, V126, P825, DOI 10.1016/j.amjmed.2013.02.036
   Van Laecke S, 2011, NEPHROL DIAL TRANSPL, V26, P2362, DOI 10.1093/ndt/gfq728
   WITTEMAN JCM, 1989, CIRCULATION, V80, P1320, DOI 10.1161/01.CIR.80.5.1320
   Xing JH, 2001, DIS COLON RECTUM, V44, P1201, DOI 10.1007/BF02234645
   Zittermann A, 2012, AM J CLIN NUTR, V95, P91, DOI 10.3945/ajcn.111.014779
NR 86
TC 37
Z9 38
U1 0
U2 21
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1121-8428
EI 1724-6059
J9 J NEPHROL
JI J. Nephrol.
PD JUN
PY 2015
VL 28
IS 3
BP 269
EP 277
DI 10.1007/s40620-014-0140-6
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA CI6SW
UT WOS:000354892900002
PM 25227765
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Chen, C
   Chang, Z
   Kuja-Halkola, R
   D'Onofrio, BM
   Larsson, H
   Andell, P
   Lichtenstein, P
   Pettersson, E
AF Chen, Cen
   Chang, Zheng
   Kuja-Halkola, Ralf
   D'Onofrio, Brian M.
   Larsson, Henrik
   Andell, Pontus
   Lichtenstein, Paul
   Pettersson, Erik
TI Associations Between General and Specific Mental Health Conditions in
   Young Adulthood and Cardiometabolic Complications in Middle Adulthood: A
   40-Year Longitudinal Familial Coaggregation Study of 672,823 Swedish
   Individuals
SO AMERICAN JOURNAL OF PSYCHIATRY
LA English
DT Article
ID MAJOR DEPRESSIVE DISORDER; METABOLIC SYNDROME; CARDIOVASCULAR MORTALITY;
   BIPOLAR DISORDER; RISK; ANXIETY; LIFE; PSYCHOPATHOLOGY; SCHIZOPHRENIA;
   COMPONENTS
AB Objective: Most mental disorders, when examined individually, are associated with an increased risk of cardiometabolic complications. However, these associations might be attributed to a general liability to psychopathology or confounded by unmeasured familial factors. The authors investigated the association between psychiatric conditions in young adulthood and the risk of cardiometabolic complications in middle adulthood, up to 40 years later. Methods: This cohort study (N=672,823) identified all individuals and their siblings born in Sweden between 1955 and 1962 and followed the cohort through 2013. Logistic regression models were used to estimate the bivariate associations between 10 psychiatric conditions or criminal convictions and five cardiometabolic complications in individuals. A general factor model was used to identify general, internalizing, externalizing, and psychotic factors based on the comorbidity among psychiatric conditions and criminal convictions. The cardiometabolic complications were then regressed on the latent general factor and three uncorrelated specific factors within a structural equation modeling framework in individuals and across sibling pairs. Results: Each psychiatric condition significantly increased the risk of cardiometabolic complications. These associations appeared nonspecific, as multivariate models indicated that most were attributable to the general factor of psychopathology, rather than to specific psychiatric conditions. There were no or only small associations between individuals' general psychopathology and their siblings' cardiometabolic complications. The same pattern was evident for the specific internalizing and psychotic factors. Conclusions: Associations between mental disorders in early life and later long-term risk of cardiometabolic complications appeared to be attributable to a general liability to psychopathology. Familial coaggregation analyses suggested that the elevated risk could not be attributed to confounders shared within families. One possibility is that lifestyle-based interventions may reduce the risk of later cardiometabolic complications for patients with several mental disorders.
C1 [Chen, Cen; Chang, Zheng; Kuja-Halkola, Ralf; D'Onofrio, Brian M.; Larsson, Henrik; Lichtenstein, Paul; Pettersson, Erik] Karolinska Inst, Dept Med Epidemiol & Biostat, Solna, Sweden.
   [D'Onofrio, Brian M.] Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN USA.
   [Larsson, Henrik] Orebro Univ, Sch Med Sci, Orebro, Sweden.
   [Andell, Pontus] Karolinska Inst, Dept Med, Unit Cardiol, Stockholm, Sweden.
   [Andell, Pontus] Karolinska Univ Hosp, Heart & Vasc Div, Stockholm, Sweden.
C3 Karolinska Institutet; Indiana University System; Indiana University
   Bloomington; Orebro University; Karolinska Institutet; Karolinska
   Institutet; Karolinska University Hospital
RP Chen, C (corresponding author), Karolinska Inst, Dept Med Epidemiol & Biostat, Solna, Sweden.
EM cen.chen@ki.se
RI Kuja-Halkola, Ralf/ABA-5061-2020; Pettersson, Erik/AAH-2531-2020;
   Larsson, Henrik/GYD-5161-2022; Chang, Zheng/LBH-0831-2024; Andell,
   Pontus/ITU-4503-2023; Andell, Pontus/N-9979-2014
OI Andell, Pontus/0000-0002-2759-1379; Kuja-Halkola,
   Ralf/0000-0002-3765-2067
FU Swedish Research Council for Health [2017-01358]; Stockholm Region
   [20190712]; China Scholarship Council; Swedish Research Council
   [2017-01358] Funding Source: Swedish Research Council
FX Supported by the Swedish Research Council for Health (grant 2017-01358)
   , ALF Funding from the Stockholm Region (grant 20190712) , and the China
   Scholarship Council.
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   [Anonymous], 2022, National patient register: socialstyrelsen
   Asparouhov T, 2009, STRUCT EQU MODELING, V16, P397, DOI 10.1080/10705510903008204
   Barlow DH, 2017, JAMA PSYCHIAT, V74, P875, DOI 10.1001/jamapsychiatry.2017.2164
   Beauchamp MR, 2018, JAMA PSYCHIAT, V75, P543, DOI 10.1001/jamapsychiatry.2018.0385
   Bedeian AG, 1997, EDUC PSYCHOL MEAS, V57, P785, DOI 10.1177/0013164497057005004
   Bernaards CA, 2005, EDUC PSYCHOL MEAS, V65, P770, DOI 10.1177/0013164404272507
   Brandt V, 2023, WORLD PSYCHIATRY, V22, P335, DOI 10.1002/wps.21097
   Butnoriene J, 2015, INT J CARDIOL, V190, P360, DOI 10.1016/j.ijcard.2015.04.122
   Caspi A, 2018, AM J PSYCHIAT, V175, P831, DOI 10.1176/appi.ajp.2018.17121383
   CATTELL RB, 1966, MULTIVAR BEHAV RES, V1, P245, DOI 10.1207/s15327906mbr0102_10
   Collins SE, 2016, ALCOHOL RES-CURR REV, V38, P83
   Corruble E, 2015, WORLD PSYCHIATRY, V14, P366, DOI 10.1002/wps.20260
   Czepielewski L, 2013, REV BRAS PSIQUIATR, V35, P88, DOI [10.1016/j.rbp.2012.07.004, 10.1016/j.rbp.2012.00.000]
   Ekbom A, 2011, METHODS MOL BIOL, V675, P215, DOI 10.1007/978-1-59745-423-0_10
   Firth J, 2020, WORLD PSYCHIATRY, V19, P360, DOI 10.1002/wps.20773
   Firth J, 2019, LANCET PSYCHIAT, V6, P675, DOI 10.1016/S2215-0366(19)30132-4
   Boreu QF, 2013, ATEN PRIM, V45, P141, DOI 10.1016/j.aprim.2012.10.010
   Henderson DC, 2015, LANCET PSYCHIAT, V2, P452, DOI 10.1016/S2215-0366(15)00115-7
   Hiles SA, 2016, DEPRESS ANXIETY, V33, P754, DOI 10.1002/da.22512
   Isomura K, 2018, BIOL PSYCHIAT, V84, P324, DOI 10.1016/j.biopsych.2017.12.003
   Johnson JG, 2002, J CONSULT CLIN PSYCH, V70, P1119, DOI 10.1037//0022-006X.70.5.1119
   Knopik VS., 2017, Behavioral genetics, V7th
   Lahey BB, 2017, PSYCHOL BULL, V143, P142, DOI 10.1037/bul0000069
   Lahey BB, 2012, J ABNORM PSYCHOL, V121, P971, DOI 10.1037/a0028355
   Lee M, 2017, GERONTOL GERIATR MED, V3, DOI 10.1177/2333721417696673
   Leone M, 2021, JAMA PSYCHIAT, V78, P302, DOI 10.1001/jamapsychiatry.2020.3786
   Li ZX, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0154990
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Muthen L.K., 2017, MPLUS USERS GUIDE ST
   Osborn DPJ, 2008, BMC PSYCHIATRY, V8, DOI 10.1186/1471-244X-8-84
   Plana-Ripoll O, 2019, JAMA PSYCHIAT, V76, P259, DOI 10.1001/jamapsychiatry.2018.3658
   Ronald A, 2022, J CHILD PSYCHOL PSYC, V63, P721, DOI 10.1111/jcpp.13644
   Roth GA, 2018, LANCET, V392, P1736, DOI 10.1016/S0140-6736(18)32203-7
   Schlaich M, 2015, LANCET DIABETES ENDO, V3, P148, DOI 10.1016/S2213-8587(14)70033-6
   Scuteri A, 2015, EUR J PREV CARDIOL, V22, P486, DOI 10.1177/2047487314525529
   Sjölander A, 2022, ANNU REV STAT APPL, V9, P71, DOI 10.1146/annurev-statistics-040120-024521
   Sweden S, 2011, The Future Population of Sweden: Projection for the Years 2011-2110
   Townsend N, 2022, NAT REV CARDIOL, V19, P133, DOI 10.1038/s41569-021-00607-3
   van Dijk G, 2008, EUR J PHARMACOL, V585, P137, DOI 10.1016/j.ejphar.2007.11.079
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Waller NG, 2018, PSYCHOMETRIKA, V83, P858, DOI 10.1007/s11336-017-9599-0
   Wang JJ, 2007, EUR HEART J, V28, P857, DOI 10.1093/eurheartj/ehl524
   Watanabe K, 2019, NAT GENET, V51, P1339, DOI 10.1038/s41588-019-0481-0
NR 46
TC 3
Z9 3
U1 0
U2 10
PU AMER PSYCHIATRIC PUBLISHING, INC
PI WASHINGTON
PA 800 MAINE AVE SW, SUITE 900, WASHINGTON, DC 20024 USA
SN 0002-953X
EI 1535-7228
J9 AM J PSYCHIAT
JI Am. J. Psychiat.
PD JUL
PY 2024
VL 181
IS 7
BP 651
EP 657
DI 10.1176/appi.ajp.20220951
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA A2G7A
UT WOS:001280771400016
PM 38263878
DA 2025-06-11
ER

PT J
AU Poggiogalle, E
   Di Lazzaro, L
   Pinto, A
   Migliaccio, S
   Lenzi, A
   Donini, LM
AF Poggiogalle, Eleonora
   Di Lazzaro, Luca
   Pinto, Alessandro
   Migliaccio, Silvia
   Lenzi, Andrea
   Donini, Lorenzo M.
TI Health-Related Quality of Life and Quality of Sexual Life in Obese
   Subjects
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID BIOELECTRICAL-IMPEDANCE ANALYSIS; BODY-MASS INDEX; METABOLIC SYNDROME;
   EXTREME OBESITY; DYSFUNCTION; OVERWEIGHT; SATISFACTION; WEIGHT;
   ASSOCIATION; PREVALENCE
AB The increased prevalence of obesity represents, currently, one of the major public health issues, due to its consequences on physical and psychological health status as well as on the psychosocial functioning. As defined by the World Health Organization, sexual health is "a state of physical, emotional, mental, and social well-being in relation to sexuality." The aim of the present study was to explore the relationship between sexual life in obese subjects and quality of life, psychological status, and disability. Methods. 95 obese subjects were recruited from June 2012 to February 2013 and underwent physical examination and measures for the assessment of quality of life, sexual life, psychological status, and disability. Results. In obese subjects sexual life was related to gender, age, psychological status, disability, and quality of life. Conclusion. As obesity is a multifactorial disease, and is accompanied by multiple comorbidities, it is difficult to identify a single causative factor responsible for the impairment of sexual life in obese subjects; thus, a thorough, multidimensional evaluation including sexual function assessment should be performed in obese people.
C1 [Poggiogalle, Eleonora; Di Lazzaro, Luca; Pinto, Alessandro; Lenzi, Andrea; Donini, Lorenzo M.] Univ Roma La Sapienza, Dept Expt Med, Med Pathophysiol Food Sci & Endocrinol Sect, I-00185 Rome, Italy.
   [Migliaccio, Silvia] Univ Rome Foro Italico, Dept Movement Human & Hlth Sci, I-00195 Rome, Italy.
C3 Sapienza University Rome; Foro Italico University of Rome
RP Poggiogalle, E (corresponding author), Univ Roma La Sapienza, Dept Expt Med, Med Pathophysiol Food Sci & Endocrinol Sect, Piazzale Aldo Moro 5, I-00185 Rome, Italy.
EM eleonora.poggiogalle@gmail.com
RI Donini, Lorenzo/AAS-3873-2020; Poggiogalle, Eleonora/AAB-9338-2019;
   Lenzi, Andrea/I-7711-2015
OI Migliaccio, Silvia/0000-0002-4563-6630; Poggiogalle,
   Eleonora/0000-0003-0862-5892; Pinto, Alessandro/0000-0002-4864-2294;
   Donini, Lorenzo/0000-0003-4692-4754; Lenzi, Andrea/0000-0002-7711-0465
CR Algul A, 2009, INT J PSYCHIAT MED, V39, P297, DOI 10.2190/PM.39.3.f
   Amidu N, 2013, DIABETOL METAB SYNDR, V5, DOI 10.1186/1758-5996-5-42
   [Anonymous], 2004, Sexual Medicine: Sexual Dysfunctions in Men and Women
   [Anonymous], 2006, SEX HEALTH
   Archer SL, 2005, DRUG AGING, V22, P823, DOI 10.2165/00002512-200522100-00003
   Bajos N, 2010, BRIT MED J, V340, DOI 10.1136/bmj.c2573
   Corona G, 2013, BEST PRACT RES CL EN, V27, P581, DOI 10.1016/j.beem.2013.05.007
   Derogatis L.R., 1994, SYMPTON CHECKLIST 90
   Diaz-Arjonilla M, 2009, INT J IMPOT RES, V21, P89, DOI 10.1038/ijir.2008.42
   Donini L. M., EATING WEIG IN PRESS
   Donini LM, 2011, DISABIL REHABIL, V33, P2509, DOI 10.3109/09638288.2011.575529
   Edwards WM, 2004, ARCH SEX BEHAV, V33, P189, DOI 10.1023/B:ASEB.0000026619.95734.d5
   El-Sakka AI, 2011, J SEX MED, V8, P937, DOI 10.1111/j.1743-6109.2011.02231.x
   Esposito K, 2007, INT J IMPOT RES, V19, P353, DOI 10.1038/sj.ijir.3901548
   Esposito K, 2005, INT J IMPOT RES, V17, P391, DOI 10.1038/sj.ijir.3901333
   Esposito K, 2011, CLIN PHARMACOL THER, V90, P169, DOI 10.1038/clpt.2011.91
   Han TS, 2011, EUR J ENDOCRINOL, V164, P1003, DOI 10.1530/EJE-10-1129
   Kirchengast S, 1996, MATURITAS, V23, P63, DOI 10.1016/0378-5122(95)00954-X
   Kolotkin R L, 2001, Obes Rev, V2, P219, DOI 10.1046/j.1467-789X.2001.00040.x
   KUSHNER RF, 1992, J AM COLL NUTR, V11, P199
   Larsen SH, 2007, INT J OBESITY, V31, P1189, DOI 10.1038/sj.ijo.0803604
   Laumann EO, 1999, JAMA-J AM MED ASSOC, V281, P537, DOI 10.1001/jama.281.6.537
   Lohman T.G., 1992, Anthropometric standardization reference manual
   Ma YL, 2009, MED HYPOTHESES, V72, P482, DOI 10.1016/j.mehy.2008.11.009
   Mannucci E, 1999, ADDICT BEHAV, V24, P345, DOI 10.1016/S0306-4603(98)00055-0
   Mannucci E, 2010, HEALTH QUAL LIFE OUT, V8, DOI 10.1186/1477-7525-8-90
   Marchesini G, 2003, DIABETES NUTR METAB, V16, P284
   McCall-Hosenfeld JS, 2008, J GEN INTERN MED, V23, P2000, DOI 10.1007/s11606-008-0820-9
   Moore RH, 2013, OBESITY, V21, P1966, DOI 10.1002/oby.20398
   Morotti E, 2013, J SEX MED, V10, P1034, DOI 10.1111/jsm.12045
   Morrison D., 2011, BRIT MED J, V343
   Nicolosi A, 2004, J AFFECT DISORDERS, V82, P235, DOI 10.1016/j.jad.2003.12.008
   Puhl RM, 2010, AM J PUBLIC HEALTH, V100, P1019, DOI 10.2105/AJPH.2009.159491
   Reuser M, 2009, OBESITY, V17, P783, DOI 10.1038/oby.2008.640
   Sarwer DB, 2013, SURG OBES RELAT DIS, V9, P997, DOI 10.1016/j.soard.2013.07.003
   Sarwer DB, 2012, OBES SURG, V22, P668, DOI 10.1007/s11695-012-0588-1
   Smith AMA, 2012, INTERN MED J, V42, P641, DOI 10.1111/j.1445-5994.2011.02597.x
   Sun SS, 2003, AM J CLIN NUTR, V77, P331, DOI 10.1093/ajcn/77.2.331
   Tan HM, 2012, J SEX MED, V9, P663, DOI 10.1111/j.1743-6109.2011.02582.x
   Visscher TLS, 2001, ANNU REV PUBL HEALTH, V22, P355, DOI 10.1146/annurev.publhealth.22.1.355
   WHO, 2000, SEX HLTH ISS
   Wyatt SB, 2006, AM J MED SCI, V331, P166, DOI 10.1097/00000441-200604000-00002
   Yaylali GF, 2010, INT J IMPOT RES, V22, P220, DOI 10.1038/ijir.2010.7
NR 43
TC 21
Z9 25
U1 0
U2 12
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2014
VL 2014
AR 847871
DI 10.1155/2014/847871
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA AC6QU
UT WOS:000332650100001
PM 24707290
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU O'Sullivan, TA
   Schmidt, KA
   Kratz, M
AF O'Sullivan, Therese A.
   Schmidt, Kelsey A.
   Kratz, Mario
TI Whole-Fat or Reduced-Fat Dairy Product Intake, Adiposity, and
   Cardiometabolic Health in Children: A Systematic Review
SO ADVANCES IN NUTRITION
LA English
DT Review
DE dairy; low-Mt; regular-fat; skim milk; whole milk; children; pediatric;
   overweight; cholesterol
ID BODY-MASS INDEX; APOB/APOA-I RATIO; METABOLIC SYNDROME; MILK
   CONSUMPTION; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; INVERSE
   ASSOCIATION; BEVERAGE PATTERNS; HDL-CHOLESTEROL; SATURATED FAT
AB Dietary guidelines commonly recommend that children aged >2 y consume reduced-fat dairy products rather than regular- or whole-Mt dairy. In adults, most studies have not found the consumption of whole-fat dairy products to be associated with increased cardiometabolic or adiposity risk. Associations in children could differ due to growth and development. We systematically reviewed the literature in indexed, peer-reviewed journals to summarize pediatric studies (children aged from 2 to 18 y) assessing associations between whole- and reduced-Mt dairy intake and measures of adiposity as well as biomarkers of cardiometabolic disease risk, including the serum lipid profile, blood pressure, low-grade chronic inflammation, oxidative stress, and measures of glucose homeostasis. For the purposes of this review, a "whole-fat" dairy product was defined as a product with the natural fat content, whereas a 'reduced-far dairy product was defined as a product with some or all of the fat removed (including "low-far and "skim" versions). A total of 29 journal articles met our criteria for inclusion. The majority were conducted in the United States and were prospective or cross-sectional observational studies, with only 1 randomized controlled trial. Studies were consistent in reporting that whole-fat dairy products were not associated with increased measures of weight gain or adiposity. Most evidence indicated that consumption of whole-Mt dairy was not associated with increased cardiometabolic risk, although a change from whole-Mt to reduced-Mt dairy improved outcomes for some risk factors in 1 study.Taken as a whole, the limited literature in this field is not consistent with dietary guidelines recommending that children consume preferably reduced-fat dairy products. High-quality randomized controlled trials in children that directly compare the effects of whole-fat compared with reduced-fat dairy intake on measures of adiposity or biomarkers of cardiometabolic disease risk are needed to provide better quality evidence in this area.
C1 [O'Sullivan, Therese A.] Edith Cowan Univ, Sch Med & Hlth Sci, Joondalup, WA, Australia.
   [Schmidt, Kelsey A.; Kratz, Mario] Fred Hutchinson Res Ctr, Div Publ Hlth Sci, Canc Prevent Program, Seattle, WA USA.
   [Kratz, Mario] Univ Washington, Dept Med, Div Metab Endocrinol & Nutr, Seattle, WA USA.
   [Kratz, Mario] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
C3 Edith Cowan University; Fred Hutchinson Cancer Center; University of
   Washington; University of Washington Seattle; University of Washington;
   University of Washington Seattle
RP O'Sullivan, TA (corresponding author), Edith Cowan Univ, Sch Med & Hlth Sci, Joondalup, WA, Australia.
EM t.osullivan@ecu.edu.au
RI O'Sullivan, Therese/D-1723-2016
OI O'Sullivan, Therese/0000-0003-1003-854X; Kratz,
   Mario/0000-0003-2660-8033
FU NIH [T32 CA094880]; MRC [MC_PC_19009] Funding Source: UKRI
FX KAS was supported by grant number T32 CA094880 from the NIH.
CR Akobeng AK, 2005, ARCH DIS CHILD, V90, P840, DOI 10.1136/adc.2004.058222
   Ambrosini GL, 2009, PUBLIC HEALTH NUTR, V12, P1807, DOI 10.1017/S1368980008004618
   [Anonymous], 2013, AUSTR DIET GUID
   Ballantyne CM, 2003, AM HEART J, V146, P227, DOI 10.1016/S0002-8703(02)94701-0
   Barba G, 2005, BRIT J NUTR, V93, P15, DOI 10.1079/BJN20041300
   Beck Amy L, 2017, Prev Med Rep, V8, P1, DOI 10.1016/j.pmedr.2017.07.005
   Beck AL, 2014, PUBLIC HEALTH NUTR, V17, P338, DOI 10.1017/S1368980012005514
   Benatar JR, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076480
   Benbrook CM, 2018, FOOD SCI NUTR, V6, P681, DOI 10.1002/fsn3.610
   Berkey CS, 2005, ARCH PEDIAT ADOL MED, V159, P543, DOI 10.1001/archpedi.159.6.543
   Bigornia SJ, 2014, J NUTR, V144, P1081, DOI 10.3945/jn.113.183640
   BIRCH LL, 1986, APPETITE, V7, P323, DOI 10.1016/S0195-6663(86)80001-0
   Burhans MS, 2019, COMPR PHYSIOL, V9, P1, DOI 10.1002/cphy.c170040
   CASTELLI WP, 1988, CAN J CARDIOL, V4, pA5
   Chandran M, 2003, DIABETES CARE, V26, P2442, DOI 10.2337/diacare.26.8.2442
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cole TJ, 2000, BMJ-BRIT MED J, V320, P1240, DOI 10.1136/bmj.320.7244.1240
   Cole TJ, 2005, EUR J CLIN NUTR, V59, P419, DOI 10.1038/sj.ejcn.1602090
   Danyliw AD, 2012, APPL PHYSIOL NUTR ME, V37, P900, DOI [10.1139/H2012-074, 10.1139/h2012-074]
   de Onis M, 2007, B WORLD HEALTH ORGAN, V85, P660, DOI 10.2471/BLT.07.043497
   de Onis M, 2006, ACTA PAEDIATR, V95, P76, DOI 10.1080/08035320500495548
   DeBoer MD, 2015, ARCH DIS CHILD, V100, P460, DOI 10.1136/archdischild-2014-306958
   Dehghan M, 2018, LANCET, V392, P2288, DOI 10.1016/S0140-6736(18)31812-9
   Dehghan M, 2017, LANCET, V390, P2050, DOI [10.1016/S0140-6736(17)32252-3, 10.1016/s0140-6736(17)32252-3]
   Dougkas A, 2019, NUTR RES REV, V32, P106, DOI 10.1017/S0954422418000227
   Dubois L, 2016, TWIN RES HUM GENET, V19, P47, DOI 10.1017/thg.2015.97
   Eriksson S., 2010, e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism, V5, pe117
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents, 2011, Pediatrics, V128 Suppl 5, pS213, DOI 10.1542/peds.2009-2107C
   Fallah Z K., 2016, J Curr Research in Science, V4, P153
   Flegal KM, 2009, AM J CLIN NUTR, V90, P1314, DOI 10.3945/ajcn.2009.28335
   Fontecha J, 2011, CURR NUTR FOOD SCI, V7, P155, DOI 10.2174/157340111797264804
   Freedman DS, 2017, OBESITY, V25, P739, DOI 10.1002/oby.21782
   Freedman DS, 2004, INT J OBESITY, V28, P10, DOI 10.1038/sj.ijo.0802544
   Gidding SS, 2006, PEDIATRICS, V117, P544, DOI [10.1542/peds.2005-2374, 10.1542/peds.2005-2565]
   Guo J, 2017, EUR J EPIDEMIOL, V32, P269, DOI 10.1007/s10654-017-0243-1
   Hamley S, 2017, NUTR J, V16, DOI 10.1186/s12937-017-0254-5
   Hendrie GA, 2011, AM J CLIN NUTR, V93, P1117, DOI 10.3945/ajcn.110.010694
   Hirahatake KM, 2020, ADV NUTR, V11, P266, DOI 10.1093/advances/nmz105
   Hirschler V, 2009, J PEDIATR-US, V154, P101, DOI 10.1016/j.jpeds.2008.06.036
   Holman RR, 2005, DIABETES CARE, V28, P1796, DOI 10.2337/diacare.28.7.1796
   Huh SY, 2010, J AM DIET ASSOC, V110, P563, DOI 10.1016/j.jada.2009.12.025
   Imamura F, 2018, PLOS MED, V15, DOI 10.1371/journal.pmed.1002670
   Jakobsen MU, 2010, AM J CLIN NUTR, V91, P1764, DOI 10.3945/ajcn.2009.29099
   Jolliffe CJ, 2007, J AM COLL CARDIOL, V49, P891, DOI 10.1016/j.jacc.2006.08.065
   Kavezade S, 2018, BMC NUTR, V4, DOI 10.1186/s40795-018-0253-8
   Korat AVA, 2019, AM J CLIN NUTR, V110, P1192, DOI 10.1093/ajcn/nqz176
   Kratz M, 2013, EUR J NUTR, V52, P1, DOI 10.1007/s00394-012-0418-1
   LaRowe TL, 2007, J AM DIET ASSOC, V107, P1124, DOI 10.1016/j.jada.2007.04.013
   Liguori I, 2018, CLIN INTERV AGING, V13, P757, DOI 10.2147/CIA.S158513
   Louie JCY, 2011, OBES REV, V12, pE582, DOI 10.1111/j.1467-789X.2011.00881.x
   Lu L, 2016, EUR J CLIN NUTR, V70, P414, DOI 10.1038/ejcn.2015.226
   Ludwig DS, 2013, JAMA PEDIATR, V167, P788, DOI 10.1001/jamapediatrics.2013.2408
   Maguire J., 2019, COW MILK FAT OBESITY
   Mansson Helena Lindmark, 2008, Food Nutr Res, V52, DOI 10.3402/fnr.v52i0.1821
   Mazahery H, 2018, NEW ZEAL MED J, V131, P54
   Ministry of Health, 2012, FOOD NUTR GUID HLTH
   Mohammadi SG, 2015, INT J ENDOCRINOL MET, V13, DOI 10.5812/ijem.25201v2
   Moreno LA, 2015, NUTR REV, V73, P8, DOI 10.1093/nutrit/nuv014
   Natarajan S, 2003, AM J PREV MED, V25, P50, DOI 10.1016/S0749-3797(03)00092-8
   National Health and Medical Research Council, 2013, Eat for Health: Australian Dietary Guidelines
   National High Blood Pressure Education Program, 2005, 4 REP DIAGN EV TREAR
   National Institute for Health Research Cambridge Biomedical Research Centre, 2015, NUTR BIOM DAPA MEAS
   Nezami M, 2016, NUTRIENTS, V8, DOI 10.3390/nu8070427
   Noel SE, 2011, J NUTR, V141, P2035, DOI 10.3945/jn.111.143420
   Nutrition Science Teamand PublicHealth England, 2018, EATW GUID
   O'Connor TM, 2006, PEDIATRICS, V118, pE1010, DOI 10.1542/peds.2005-2348
   O'Sullivan TA, MILKY WAY STUDY COMP
   O'Sullivan TA, 2016, NUTRIENTS, V8, DOI 10.3390/nu8010022
   O'Sullivan TA, 2013, AM J PUBLIC HEALTH, V103, pE31, DOI 10.2105/AJPH.2013.301492
   Papandreou D, 2013, HIPPOKRATIA, V17, P42
   Phillips SM, 2003, INT J OBESITY, V27, P1106, DOI 10.1038/sj.ijo.0802370
   Poslusna K, 2009, BRIT J NUTR, V101, pS73, DOI 10.1017/S0007114509990602
   Praagman J, 2015, EUR J NUTR, V54, P981, DOI 10.1007/s00394-014-0774-0
   Ramsden CE, 2010, BRIT J NUTR, V104, P1586, DOI 10.1017/S0007114510004010
   Risérus U, 2017, CURR OPIN LIPIDOL, V28, P46, DOI 10.1097/MOL.0000000000000381
   Samuelson G, 2007, BR J NUTR, V85, P333
   Scharf RJ, 2013, ARCH DIS CHILD, V98, P335, DOI 10.1136/archdischild-2012-302941
   Schianca GPC, 2011, NUTR METAB CARDIOVAS, V21, P406, DOI 10.1016/j.numecd.2009.11.002
   Schwingshackl L, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0157461
   Tallini R.A., 2015, AM J FOOD TECHNOLOGY, V10, P265, DOI DOI 10.3923/AJFT.2015.265.272
   Thorning TK, 2017, AM J CLIN NUTR, V105, P1033, DOI 10.3945/ajcn.116.151548
   US National Library of Medicine, MEDLINER DESCR DAT
   USDA, 2015, Dietary guidelines for Americans
   Velde SJT, 2011, J HUM NUTR DIET, V24, P233, DOI 10.1111/j.1365-277X.2010.01149.x
   Villalpando S, 2015, BRIT J NUTR, V114, P788, DOI 10.1017/S0007114515002330
   Wallace TM, 2004, DIABETES CARE, V27, P1487, DOI 10.2337/diacare.27.6.1487
   Walldius G, 2006, J INTERN MED, V259, P493, DOI 10.1111/j.1365-2796.2006.01643.x
   Walldius G, 2012, LIPOPROTEINS ROLE HL
   Wang HF, 2011, OBESITY, V19, P2404, DOI 10.1038/oby.2011.234
   Wang K, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0848-8
   Wang WJ, 2016, ANN EPIDEMIOL, V26, P870, DOI 10.1016/j.annepidem.2016.09.005
   Wang ZV, 2016, J MOL CELL BIOL, V8, P93, DOI 10.1093/jmcb/mjw011
   Wen JH, 2017, J CLIN HYPERTENS, V19, P771, DOI 10.1111/jch.13038
   Willett W., 2017, Nutritional epidemiology
   Williams EP, 2015, CURR OBES REP, V4, P363, DOI 10.1007/s13679-015-0169-4
   Wong VCH, 2019, J PEDIATR-US, V211, P105, DOI 10.1016/j.jpeds.2019.03.047
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
NR 98
TC 34
Z9 36
U1 2
U2 21
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2161-8313
EI 2156-5376
J9 ADV NUTR
JI Adv. Nutr.
PD JUL
PY 2020
VL 11
IS 4
BP 928
EP 950
DI 10.1093/advances/nmaa011
PG 23
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OX1PF
UT WOS:000593344900012
PM 32119732
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Watson, NA
   Dyer, KA
   Buckley, JD
   Brinkworth, GD
   Coates, AM
   Parfitt, G
   Howe, PRC
   Noakes, M
   Dye, L
   Chadwick, H
   Murphy, KJ
AF Watson, Nerylee Ann
   Dyer, Kathryn Ann
   Buckley, Jonathan David
   Brinkworth, Grant David
   Coates, Alison Mary
   Parfitt, Gaynor
   Howe, Peter Ranald Charles
   Noakes, Manny
   Dye, Louise
   Chadwick, Helen
   Murphy, Karen Joy
TI A randomised trial comparing low-fat diets differing in carbohydrate and
   protein ratio, combined with regular moderate intensity exercise, on
   glycaemic control, cardiometabolic risk factors, food cravings,
   cognitive function and psychological wellbeing in adults with type 2
   diabetes: Study protocol
SO CONTEMPORARY CLINICAL TRIALS
LA English
DT Article
DE Diabetes; Glycemic; Cardiometabolic; Cognitive; Psychological; Protocol
ID IMPAIRED GLUCOSE-TOLERANCE; QUALITY-OF-LIFE; EMOTIONAL DISTRESS; LOAD
   BREAKFAST; PROBLEM AREAS; WEIGHT-LOSS; MELLITUS; VALIDATION; HEALTH;
   QUESTIONNAIRE
AB Background: Hypocaloric low-fat diets, high in protein with moderate carbohydrate (HP) can enhance weight loss, improve glycaemic control and improve cardiometabolic health risk factors in type 2 diabetes mellitus (T2DM). However, it is unclear whether the metabolic benefits observed during weight loss are sustained during energy-balance and weight maintenance. Furthermore, there is a lack of evidence regarding the effect of HP diets on food cravings, cognitive function and psychological wellbeing in T2DM, despite carbohydrate food cravings, cognitive impairment and depression being associated with hyperglycaemia.
   Methods/design: Overweight/obese adults with T2DM were randomised to consume either a HP diet (n = 32, similar to 32% protein, 33% carbohydrate, 30% fat) or a higher-carbohydrate diet (HC, n = 29, similar to 22% protein, 51% carbohydrate, 22% fat) for 24 weeks with 30 min of moderate intensity exercise five days/week for the study duration. There were 2 phases: a 12 week weight loss phase followed by a 12 week weight maintenance phase. Primary outcome was glycaemic control (glycosylated haemoglobin; HbA1c). Secondary outcomes were cardiometabolic risk factors (body composition, fasting blood pressure, blood lipids, glucose, insulin and C-reactive protein), food cravings, cognitive function (memory; psychomotor and executive function and psychological well-being. Outcomes were measured at baseline and the end of each 12-week intervention phase. Data will be analysed as intention-to-treat using linear mixed effects models.
   Conclusion: This study will examine the effects of two dietary interventions on health outcomes in T2DM during weight loss and notably following weight maintenance where there is a paucity of evidence. (C) 2015 Published by Elsevier Inc.
C1 [Watson, Nerylee Ann; Dyer, Kathryn Ann; Buckley, Jonathan David; Coates, Alison Mary; Parfitt, Gaynor; Murphy, Karen Joy] Univ S Australia, Sansom Inst Hlth Res, Alliance Res Exercise Nutr & Act, Adelaide, SA 5001, Australia.
   [Brinkworth, Grant David; Noakes, Manny] Commonwealth Sci & Ind Res Org, Food & Nutr, Adelaide, SA 5000, Australia.
   [Howe, Peter Ranald Charles] Univ Newcastle, Sch Biomed Sci & Pharm, Clin Nutr Res Ctr, Callaghan, NSW 2308, Australia.
   [Dye, Louise; Chadwick, Helen] Univ Leeds, Sch Psychol, Leeds LS2 9JT, W Yorkshire, England.
C3 University of South Australia; Commonwealth Scientific & Industrial
   Research Organisation (CSIRO); University of Newcastle; University of
   Leeds
RP Murphy, KJ (corresponding author), Univ S Australia, Sansom Inst Hlth Res, Alliance Res Exercise Nutr & Act, GPO Box 2471, Adelaide, SA 5001, Australia.
EM nerylee.watson@mymail.unisa.edu.au; Kate.Dyer@unisa.edu.au;
   jon.Bucldey@unisa.edu.au; grant.brinkworth@csiro.au;
   Alison.Coates@unisa.edu.au; Gaynor.Parfitt@unisa.edu.au;
   Peter.Howe@newcastle.edu.au; manny.noalces@csiro.au; LDye@leeds.ac.uk;
   H.KChadwick@leeds.ac.uk; Karen.Murphy@unisa.edu.au
RI noakes, manny/H-2813-2013; Brinkworth, Grant/H-2815-2013; Chadwick,
   Helen/HSH-3884-2023; Buckley, Jonathan/B-7830-2009; Howe,
   Peter/A-5006-2008; Murphy, Karen/B-5163-2009; Parfitt,
   Gaynor/G-7640-2012; Coates, Alison/A-3988-2009
OI Chadwick, Helen/0000-0002-8022-5490; Parfitt,
   Gaynor/0000-0002-5547-5797; Murphy, Karen/0000-0002-2589-1319; Howe,
   Peter/0000-0001-6546-7742; Brinkworth, Grant/0000-0001-9017-8395;
   Buckley, Jonathan/0000-0003-0298-2186; Coates,
   Alison/0000-0003-1031-2545
FU Pork Co-operative Research Centre (Pork CRC), an Australian Government
   funding initiative
FX The authors thank the participants for taking part in this trial. Also
   thank you to Professor Graham Giles of the Cancer Epidemiology Centre of
   The Cancer Council Victoria, for permission to use the Dietary
   Questionnaire for Epidemiological Studies (Version 2), Melbourne: The
   Cancer Council Victoria, 1996. We gratefully acknowledge the following
   people for their assistance: Prof Adrian Esterman for assistance with
   statistical design, Sarah Biermann for assisting with volunteer
   screening and data entry, Dr. Simon Spedding for the medical management
   of trial recruitment, Paul Foster, Janna Lutze and Pennie Taylor for
   assisting in planning the diets and Julia Weaver and Louise Massie for
   trial assistance. Finally, we would like to acknowledge the following
   organisations for their generous donations of study foods including:
   Australian Health and Nutrition Association Ltd. (Sanitarium) for
   Weet-Bix (TM) breakfast cereal, Bega Cheese Limited for reduced-fat
   cheese and The Almond Board of Australia for almonds. This study was
   funded by a grant from the Pork Co-operative Research Centre (Pork CRC),
   an Australian Government funding initiative. No sponsor or funding
   source had a role in any aspect of the design or conduct of this study.
CR Al-Dubai SA, 2014, ASEAN J PSYCHIATR, V15, P8
   Altman DG, 2005, BRIT MED J, V330, P843, DOI 10.1136/bmj.330.7495.843
   [Anonymous], 1998, BORGS PERCEIVED EXER
   Australian Government Department of Health and Ageing, 1998, AUSTR GUID HLTH EAT
   Awad N, 2004, J CLIN EXP NEUROPSYC, V26, P1044, DOI 10.1080/13803390490514875
   Bonora E, 2000, DIABETES CARE, V23, P57, DOI 10.2337/diacare.23.1.57
   Boyer JG, 1997, MED CARE, V35, P440, DOI 10.1097/00005650-199705000-00003
   BRAZIER JE, 1992, BMJ-BRIT MED J, V305, P160, DOI 10.1136/bmj.305.6846.160
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Cukierman T, 2005, DIABETOLOGIA, V48, P2460, DOI 10.1007/s00125-005-0023-4
   de Queiroz FA, 2009, REV LAT-AM ENFERM, V17, P708, DOI 10.1590/S0104-11692009000500018
   De Renzi E, 1975, Cortex, V11, P341
   DERENZI E, 1977, CORTEX, V13, P424, DOI 10.1016/S0010-9452(77)80022-1
   Dong JY, 2013, BRIT J NUTR, V110, P781, DOI 10.1017/S0007114513002055
   Dorman RB, 2012, ANN SURG, V255, P287, DOI 10.1097/SLA.0b013e318232b033
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Galletly C, 2007, APPETITE, V49, P590, DOI 10.1016/j.appet.2007.03.222
   Gannon MC, 2011, METABOLISM, V60, P1300, DOI 10.1016/j.metabol.2011.01.016
   Giles G., 1996, DIETARY QUESTIONNAIR
   Gross CC, 2007, DIABETES RES CLIN PR, V76, P455, DOI 10.1016/j.diabres.2006.09.022
   Hodge A, 2000, AUST NZ J PUBL HEAL, V24, P576, DOI 10.1111/j.1467-842X.2000.tb00520.x
   Kalbe E, 2004, INT J GERIATR PSYCH, V19, P136, DOI 10.1002/gps.1042
   Koch W, 2002, CLIN CHEM LAB MED, V40, P1123, DOI 10.1515/CCLM.2002.197
   Lamport DJ, 2014, NUTR METAB CARDIOVAS, V24, P1128, DOI 10.1016/j.numecd.2014.04.015
   Lamport DJ, 2013, CLIN NUTR, V32, P265, DOI 10.1016/j.clnu.2012.07.008
   Magalhaes SD, 2012, CLIN NEUROPSYCHIATR, V9, P129
   Malec J., 1991, Psychological Assessment: A Journal of Consulting and Clinical Psychology, V3, P82
   Marfell-Jones MJ., 2012, International standards for anthropometric assessment
   Mayer SB, 2014, DIABETES OBES METAB, V16, P90, DOI 10.1111/dom.12191
   Meneghini LF, 2006, DIABETES CARE, V29, P2760, DOI 10.2337/dc06-1364
   MORRIS RG, 1988, J NEUROL NEUROSUR PS, V51, P757, DOI 10.1136/jnnp.51.6.757
   Nathan DM, 2009, DIABETES CARE, V32, P193, DOI 10.2337/dc08-9025
   Nijs IMT, 2007, APPETITE, V49, P38, DOI 10.1016/j.appet.2006.11.001
   Nouwen A, 2010, DIABETOLOGIA, V53, P2480, DOI 10.1007/s00125-010-1874-x
   Parfitt G, 2012, MED SCI SPORT EXER, V44, P1613, DOI 10.1249/MSS.0b013e31824d266e
   Rey A., 1964, CLIN EXAMINATION PSY
   Schofield W N, 1985, Hum Nutr Clin Nutr, V39 Suppl 1, P5
   SIMON HA, 1975, COGNITIVE PSYCHOL, V7, P268, DOI 10.1016/0010-0285(75)90012-2
   Skovlund E., 2005, Diabetes Spectrum, V18, P136, DOI [10.2337/diaspect.18.3.136, DOI 10.2337/DIASPECT.18.3.136]
   Spauwen PJJ, 2013, DIABETES CARE, V36, P1554, DOI 10.2337/dc12-0746
   Tarrasch R, 2003, HUM PSYCHOPHARM CLIN, V18, P603, DOI 10.1002/hup.534
   Tovote KA, 2014, DIABETES CARE, V37, P2427, DOI 10.2337/dc13-2918
   van den Berg E, 2009, BBA-MOL BASIS DIS, V1792, P470, DOI 10.1016/j.bbadis.2008.09.004
   Vijayakumar T.M., 2012, European Journal of Applied Sciences, V4, P1
   Wang YC, 2011, J HAND THER, V24, P313, DOI 10.1016/j.jht.2011.05.001
   Ware JE, 2000, SPINE, V25, P3130, DOI 10.1097/00007632-200012150-00008
   Welch GW, 1997, DIABETES CARE, V20, P760, DOI 10.2337/diacare.20.5.760
   White MA, 2002, OBES RES, V10, P107, DOI 10.1038/oby.2002.17
   Wong RHX, 2014, CURR DIABETES REP, V14, DOI 10.1007/s11892-014-0547-4
   Wycherley TP, 2014, J DIABETES INVEST, V5, P94, DOI 10.1111/jdi.12120
   Yu JH, 2013, DIABETIC MED, V30, P1080, DOI 10.1111/dme.12209
NR 51
TC 12
Z9 12
U1 0
U2 54
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1551-7144
EI 1559-2030
J9 CONTEMP CLIN TRIALS
JI Contemp. Clin. Trials
PD NOV
PY 2015
VL 45
BP 217
EP 225
DI 10.1016/j.cct.2015.11.001
PN B
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA DA4FJ
UT WOS:000367755200012
PM 26546883
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Rakel, RE
AF Rakel, Robert E.
TI Clinical and Societal Consequences of Obstructive Sleep Apnea and
   Excessive Daytime Sleepiness
SO POSTGRADUATE MEDICINE
LA English
DT Article
DE excessive daytime sleepiness; obstructive sleep apnea; primary care;
   quality of life; comorbidities
ID POSITIVE AIRWAY PRESSURE; QUALITY-OF-LIFE; GENERAL-POPULATION SAMPLE;
   BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; DEPRESSIVE
   SYMPTOMS; DRIVING SIMULATOR; MEDICAL THERAPY; RISK-FACTOR
AB Obstructive sleep apnea (OSA) is the most common sleep-related breathing disorder. Although frequently undiagnosed, OSA is highly prevalent and presents most often with excessive daytime sleepiness (EDS). While obesity is the major predisposing factor, patients with OSA and EDS are at increased risk of other conditions, including cardiovascular disease, type 2 diabetes, cognitive impairment. and depression. Significant consequences include morbidity and mortality from the associated conditions in addition to personal and societal consequences of cognitive impairment, such as driving and workplace accidents. Primary care physicians are ideally placed to screen for OSA and EDS in patients who present with commonly comorbid conditions such as obesity, cardiovascular disease, metabolic syndrome, and depression. Conversely, treatment of OSA and associated EDS might help alleviate significant comorbidities and their clinical and societal consequences.
C1 Baylor Coll Med, Dept Family & Community Med, Houston, TX 77098 USA.
C3 Baylor College of Medicine
RP Rakel, RE (corresponding author), Baylor Coll Med, Dept Family & Community Med, Mail Stop BCM700,3701 Kirby Dr,Suite 600, Houston, TX 77098 USA.
EM rrakel@bcm.edu
FU Anthemis Consulting Ltd.; Cephalon Inc., Frazer, PA
FX The author thanks Daniel I. Loube, MD, Providence Physician Division,
   Beaverton, OR, for useful discussions. Editorial support was provided by
   Anthemis Consulting Ltd. and was funded by Cephalon Inc., Frazer, PA.
   who provided a medical accuracy review. The author was not compensated
   and retained full editorial control over the content of the paper.
CR Akashiba T, 2002, CHEST, V122, P861, DOI 10.1378/chest.122.3.861
   Alajmi M, 2007, LUNG, V185, P67, DOI 10.1007/s00408-006-0117-x
   Altin R, 2005, J CLIN ULTRASOUND, V33, P80, DOI 10.1002/jcu.20093
   Amer Soc Anesthesiologists, 2006, ANESTHESIOLOGY, V104, P1081
   [Anonymous], 2005, The International Classification of Sleep Disorders, V2nd
   Arzt M, 2005, AM J RESP CRIT CARE, V172, P1447, DOI 10.1164/rccm.200505-702OC
   Babu AR, 2005, ARCH INTERN MED, V165, P447, DOI 10.1001/archinte.165.4.447
   Barbé F, 2001, ANN INTERN MED, V134, P1015, DOI 10.7326/0003-4819-134-11-200106050-00007
   Bardwell WA, 2003, AM J PSYCHIAT, V160, P350, DOI 10.1176/appi.ajp.160.2.350
   Bardwell WA, 2007, J AFFECT DISORDERS, V97, P181, DOI 10.1016/j.jad.2006.06.013
   Becker HF, 2003, CIRCULATION, V107, P68, DOI 10.1161/01.CIR.0000042706.47107.7A
   Bixler EO, 1998, AM J RESP CRIT CARE, V157, P144, DOI 10.1164/ajrccm.157.1.9706079
   Bixler EO, 2005, J CLIN ENDOCR METAB, V90, P4510, DOI 10.1210/jc.2005-0035
   Bixler EO, 2001, AM J RESP CRIT CARE, V163, P608, DOI 10.1164/ajrccm.163.3.9911064
   Bixler EO, 2000, ARCH INTERN MED, V160, P2289, DOI 10.1001/archinte.160.15.2289
   Campos-Rodriguez F, 2005, CHEST, V128, P624, DOI 10.1378/chest.128.2.624
   Can M, 2006, CHEST, V129, P233, DOI 10.1378/chest.129.2.233
   Chervin RD, 2000, CHEST, V118, P372, DOI 10.1378/chest.118.2.372
   Choi JB, 2006, SLEEP, V29, P1531, DOI 10.1093/sleep/29.12.1531
   Collop NA, 2007, J CLIN SLEEP MED, V3, P737
   Doghramji Paul P, 2008, J Fam Pract, V57, pS17
   Doherty LS, 2005, CHEST, V127, P2076, DOI 10.1378/chest.127.6.2076
   Durán J, 2001, AM J RESP CRIT CARE, V163, P685, DOI 10.1164/ajrccm.163.3.2005065
   Engleman HM, 2004, THORAX, V59, P618, DOI 10.1136/thx.2003.015867
   Ferini-Strambi L, 2003, BRAIN RES BULL, V61, P87, DOI 10.1016/S0361-9230(03)00068-6
   Gami AS, 2004, CIRCULATION, V110, P364, DOI 10.1161/01.CIR.0000136587.68725.8E
   Gami AS, 2003, ENDOCRIN METAB CLIN, V32, P869, DOI 10.1016/S0889-8529(03)00069-0
   Giles TL, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001106.pub3
   Gottlieb DJ, 1999, AM J RESP CRIT CARE, V159, P502, DOI 10.1164/ajrccm.159.2.9804051
   Grunstein RR, 2007, SLEEP, V30, P703, DOI 10.1093/sleep/30.6.703
   Guilleminault C, 2001, BRAIN, V124, P1482, DOI 10.1093/brain/124.8.1482
   Haentjens P, 2007, ARCH INTERN MED, V167, P757, DOI 10.1001/archinte.167.8.757
   Hamilton GS, 2004, INTERN MED J, V34, P420, DOI 10.1111/j.1445-5994.2004.00596.x
   Harsch IA, 2004, AM J RESP CRIT CARE, V169, P156, DOI 10.1164/rccm.200302-206OC
   Hiestand DM, 2006, CHEST, V130, P780, DOI 10.1378/chest.130.3.780
   Horstmann S, 2000, SLEEP, V23, P383
   *I CLIN SYST IMPR, 2008, HLTH CAR GUID DIAGN
   Ip MSM, 2002, AM J RESP CRIT CARE, V165, P670, DOI 10.1164/ajrccm.165.5.2103001
   JOHNS MW, 1991, SLEEP, V14, P540, DOI 10.1093/sleep/14.6.540
   KALES A, 1985, J CHRON DIS, V38, P427, DOI 10.1016/0021-9681(85)90138-9
   Kapur Vishesh, 2002, Sleep Breath, V6, P49, DOI 10.1055/s-2002-32318
   Kingshott Ruth N, 2004, Sleep Breath, V8, P61, DOI 10.1007/s11325-004-0061-z
   Lacasse Y, 2002, EUR RESPIR J, V19, P499, DOI 10.1183/09031936.02.00216902
   Leung RST, 2001, AM J RESP CRIT CARE, V164, P2147, DOI 10.1164/ajrccm.164.12.2107045
   Lim W, 2007, J CLIN SLEEP MED, V3, P380
   Lindberg E, 2001, AM J RESP CRIT CARE, V164, P2031, DOI 10.1164/ajrccm.164.11.2102028
   Lindberg E, 2006, SLEEP MED, V7, P553, DOI 10.1016/j.sleep.2005.12.010
   Mansfield Darren, 2005, Heart Lung Circ, V14 Suppl 2, pS2, DOI 10.1016/j.hlc.2005.08.010
   Marcus CL, 2002, PEDIATRICS, V109, P704
   Marin JM, 2005, LANCET, V365, P1046, DOI 10.1016/S0140-6736(05)71141-7
   Mittal VA, 2011, PSYCHIAT RES, V189, P158, DOI 10.1016/j.psychres.2011.06.006
   Morgenthaler TI, 2006, SLEEP, V29, P1031
   Mulgrew AT, 2007, SLEEP MED, V9, P42, DOI 10.1016/j.sleep.2007.01.009
   Munoz R, 2006, STROKE, V37, P2317, DOI 10.1161/01.STR.0000236560.15735.0f
   Netzer N, 1998, STROKE, V29, P87, DOI 10.1161/01.STR.29.1.87
   Netzer NC, 2003, CHEST, V124, P1406, DOI 10.1378/chest.124.4.1406
   Newman AB, 2000, J AM GERIATR SOC, V48, P115, DOI 10.1111/j.1532-5415.2000.tb03901.x
   Nieto FJ, 2000, JAMA-J AM MED ASSOC, V283, P1829, DOI 10.1001/jama.283.14.1829
   Ohayon MM, 2000, J NERV MENT DIS, V188, P340, DOI 10.1097/00005053-200006000-00004
   Orth M, 2005, EUR RESPIR J, V26, P898, DOI 10.1183/09031936.05.00054704
   Pack AI, 2006, AM J RESP CRIT CARE, V173, P7, DOI 10.1164/rccm.200509-1478OE
   Pagel JF, 2007, J AM BOARD FAM MED, V20, P392, DOI 10.3122/jabfm.2007.04.060201
   Parish JM, 2004, MAYO CLIN PROC, V79, P1036, DOI 10.4065/79.8.1036
   Peker Y, 1999, EUR RESPIR J, V14, P179, DOI 10.1034/j.1399-3003.1999.14a30.x
   Peppard PE, 2000, NEW ENGL J MED, V342, P1378, DOI 10.1056/NEJM200005113421901
   Pepperell JCT, 2002, LANCET, V359, P204, DOI 10.1016/S0140-6736(02)07445-7
   Punjabi NM, 2004, AM J EPIDEMIOL, V160, P521, DOI 10.1093/aje/kwh261
   Punjabi NM, 2002, AM J RESP CRIT CARE, V165, P677, DOI 10.1164/ajrccm.165.5.2104087
   Resta O, 2001, INT J OBESITY, V25, P669, DOI 10.1038/sj.ijo.0801603
   Robinson GV, 2006, EUR RESPIR J, V27, P1229, DOI 10.1183/09031936.06.00062805
   Sahlin C, 2008, ARCH INTERN MED, V168, P297, DOI 10.1001/archinternmed.2007.70
   Sanner BM, 2000, EUR RESPIR J, V16, P648, DOI 10.1034/j.1399-3003.2000.16d14.x
   Sassani A, 2004, SLEEP, V27, P453, DOI 10.1093/sleep/27.3.453
   Sateia MJ, 2003, CLIN CHEST MED, V24, P249, DOI 10.1016/S0272-5231(03)00014-5
   Schroder Carmen M, 2005, Ann Gen Psychiatry, V4, P13, DOI 10.1186/1744-859X-4-13
   SFORZA E, 1992, J NEUROL SCI, V110, P21, DOI 10.1016/0022-510X(92)90004-5
   Sforza E, 2003, EUR RESPIR J, V21, P682, DOI 10.1183/09031936.03.00087303
   SHAH NA, 2007, AM J RESP CRIT CARE, V175, pA295
   Shahar E, 2001, AM J RESP CRIT CARE, V163, P19, DOI 10.1164/ajrccm.163.1.2001008
   Shamsuzzaman ASM, 2003, JAMA-J AM MED ASSOC, V290, P1906, DOI 10.1001/jama.290.14.1906
   Shaw JE, 2008, DIABETES RES CLIN PR, V81, P2, DOI 10.1016/j.diabres.2008.04.025
   Silverberg DS, 2002, AM FAM PHYSICIAN, V65, P229
   Tasali Esra, 2008, Proc Am Thorac Soc, V5, P207, DOI 10.1513/pats.200708-139MG
   Tasali E, 2008, CHEST, V133, P496, DOI 10.1378/chest.07-0828
   Terán-Santos J, 1999, NEW ENGL J MED, V340, P847, DOI 10.1056/NEJM199903183401104
   Thurnheer R, 2007, SWISS MED WKLY, V137, P217
   Turkington PM, 2004, THORAX, V59, P56
   Ulfberg J, 2000, SCAND J WORK ENV HEA, V26, P237, DOI 10.5271/sjweh.537
   Veasey SC, 2006, SLEEP, V29, P1036, DOI 10.1093/sleep/29.8.1036
   Vgontzas AN, 2003, J INTERN MED, V254, P32, DOI 10.1046/j.1365-2796.2003.01177.x
   Weaver TE, 2007, SLEEP, V30, P711, DOI 10.1093/sleep/30.6.711
   Wessendorf TE, 2000, AM J RESP CRIT CARE, V162, P2039, DOI 10.1164/ajrccm.162.6.2001048
   West SD, 2006, THORAX, V61, P945, DOI 10.1136/thx.2005.057745
   West SD, 2007, THORAX, V62, P969, DOI 10.1136/thx.2006.074351
   Yaggi HK, 2005, NEW ENGL J MED, V353, P2034, DOI 10.1056/NEJMoa043104
   Young T, 1997, SLEEP, V20, P608, DOI 10.1093/sleep/20.8.608
   Young T, 2002, AM J RESP CRIT CARE, V165, P1217, DOI 10.1164/rccm.2109080
   YOUNG T, 1993, NEW ENGL J MED, V328, P1230, DOI 10.1056/NEJM199304293281704
   Young T, 2002, ARCH INTERN MED, V162, P893, DOI 10.1001/archinte.162.8.893
   Young T, 1997, SLEEP, V20, P705, DOI 10.1093/sleep/20.9.705
NR 100
TC 59
Z9 68
U1 0
U2 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0032-5481
EI 1941-9260
J9 POSTGRAD MED
JI Postgrad. Med.
PD JAN
PY 2009
VL 121
IS 1
BP 86
EP 95
DI 10.3810/pgm.2009.01.1957
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 399ML
UT WOS:000262803900008
PM 19179816
DA 2025-06-11
ER

PT J
AU Kasak, M
   Ceylan, MF
   Hesapcioglu, ST
   Senat, A
   Erel, Ö
AF Kasak, Meryem
   Ceylan, Mehmet Fatih
   Hesapcioglu, Selma Tural
   Senat, Almila
   Erel, Ozcan
TI Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Levels in
   Adolescent with Bipolar Disorder and Their Relationship with Metabolic
   Parameters
SO JOURNAL OF MOLECULAR NEUROSCIENCE
LA English
DT Article
DE Bipolar disorder; Etiology; Inflammation; Metabolic syndrome; PPAR
   gamma; Adolescence
ID MOOD DISORDERS; SCHIZOPHRENIA; PIOGLITAZONE; INFLAMMATION; RELIABILITY;
   PREVALENCE; DEPRESSION; CHILDREN; VALIDITY; EPISODE
AB Peroxisome proliferator-activated receptor gamma (PPAR gamma) is one of the immune and metabolic regulatory agents. This study examined the serum PPAR gamma levels and metabolic syndrome (MetS) parameters in pediatric bipolar disorder (PBD) adolescents and compared them with healthy subjects. Serum PPAR gamma levels, fasting blood glucose (FBG), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), and fasting insulin levels of 39 PBD-type I (age range: 14-18) and 36 age- and sex-matched healthy control subjects were compared. The anthropometric measurements were also analyzed, including body weight, height, body mass index (BMI), waist circumference (WC), and blood pressure measurements. The PPAR gamma levels were significantly lower, and the MetS prevalence was significantly higher in the PBD group than in the control group. The mean BMI, WC, serum TG, and FBG values of the PBD group were statistically higher than the healthy control group. There was no significant relationship between the PPAR gamma levels and metabolic parameters except fasting glucose. Lower PPAR gamma activity and higher MetS prevalence in PBD indicate dysregulation of immune and metabolic regulatory parameters. These results may shed light on developing new PBD medications.
C1 [Kasak, Meryem] Ankara City Hosp, Dept Child & Adolescent Psychiat, Ankara, Turkey.
   [Ceylan, Mehmet Fatih; Hesapcioglu, Selma Tural] Ankara Yildirim Beyazit Univ, Fac Med, Dept Child & Adolescent Psychiat, Ankara, Turkey.
   [Senat, Almila] Taksim Training & Res Hosp, Dept Biochem, Istanbul, Turkey.
   [Erel, Ozcan] Ankara City Hosp, Dept Biochem, Ankara, Turkey.
C3 City Hospital Ankara; Ankara Yildirim Beyazit University; Istanbul
   Gaziosmanpasa Taksim Training & Research Hospital; City Hospital Ankara
RP Kasak, M (corresponding author), Ankara City Hosp, Dept Child & Adolescent Psychiat, Ankara, Turkey.
EM meryemkasak90@gmail.com
RI Şenat, Almila/ACJ-4022-2022; Kaşak, Meryem/HGF-0390-2022; EREL,
   Ozcan/U-1008-2019; Tural Hesapcioglu, Selma/V-9119-2017
OI kasak, meryem/0000-0003-0176-868X; SENAT, Almila/0000-0002-5806-562X;
   Tural Hesapcioglu, Selma/0000-0002-4816-0228
CR American Psychiatric Association, 2013, Diagnostic and statistical manual of mental disorders, V5th ed, DOI DOI 10.1176/APPI.BOOKS.9780890425596
   Bensinger SJ, 2008, NATURE, V454, P470, DOI 10.1038/nature07202
   Calkin C, 2009, BIPOLAR DISORD, V11, P650, DOI 10.1111/j.1399-5618.2009.00730.x
   Chawla A, 2001, SCIENCE, V294, P1866, DOI 10.1126/science.294.5548.1866
   Drexhage RC, 2011, INT REV NEUROBIOL, V101, P169, DOI 10.1016/B978-0-12-387718-5.00007-9
   Erzin G, 2019, PSYCHIAT CLIN PSYCH, V29, P298, DOI 10.1080/24750573.2018.1471882
   Fidaleo M, 2014, CURR MED CHEM, V21, P2803, DOI 10.2174/0929867321666140303143455
   García-Alvarez L, 2018, EUR PSYCHIAT, V47, P50, DOI 10.1016/j.eurpsy.2017.09.007
   Goldstein TR, 2009, J AFFECT DISORDERS, V114, P174, DOI 10.1016/j.jad.2008.07.001
   Goldstein TR, 2005, BIPOLAR DISORD, V7, P525, DOI 10.1111/j.1399-5618.2005.00263.x
   Heneka MT, 2007, BBA-MOL CELL BIOL L, V1771, P1031, DOI 10.1016/j.bbalip.2007.04.016
   Hou LP, 2016, LANCET, V387, P1085, DOI 10.1016/S0140-6736(16)00143-4
   ISSEMANN I, 1990, NATURE, V347, P645, DOI 10.1038/347645a0
   Jiang CY, 1998, NATURE, V391, P82, DOI 10.1038/34184
   Kapadia R, 2008, FRONT BIOSCI-LANDMRK, V13, P1813, DOI 10.2741/2802
   Kapczinski NS, 2017, EXPERT REV NEUROTHER, V17, P277, DOI 10.1080/14737175.2017.1240615
   Karadag Figen, 2002, Turk Psikiyatri Derg, V13, P107
   Kaufman J., 2016, Schedule for Affective Disorders and Schizophrenia for School Aged Children Lifetime Version
   Kemp DE, 2014, CNS DRUGS, V28, P571, DOI 10.1007/s40263-014-0158-2
   Kim Y, 2017, FRONT CELL NEUROSCI, V11, DOI 10.3389/fncel.2017.00030
   KOVACS M, 1981, ACTA PAEDOPSYCHIATR, V46, P305
   Lan MJ, 2008, J MOL NEUROSCI, V35, P225, DOI 10.1007/s12031-008-9056-8
   Li C, 2019, J CLIN PSYCHIAT, V80, DOI 10.4088/JCP.18m12422
   Liu YR, 2014, PSYCHIAT INVEST, V11, P179, DOI 10.4306/pi.2014.11.2.179
   Martínez-Gras I, 2011, SCHIZOPHR RES, V128, P15, DOI 10.1016/j.schres.2011.01.018
   McElroy SL, 2014, J CLIN PSYCHIAT, V75, P46, DOI [10.4088/JCP.13010tx4c, 10.4088/JCP.13r08634]
   McElroy SL, 2012, CURR PSYCHIAT REP, V14, P650, DOI 10.1007/s11920-012-0313-8
   McIntyre RS, 2012, ANN CLIN PSYCHIATRY, V24, P69
   Meyer JM, 2008, SCHIZOPHR RES, V101, P273, DOI 10.1016/j.schres.2007.12.487
   Mirza AZ, 2019, EUR J MED CHEM, V166, P502, DOI 10.1016/j.ejmech.2019.01.067
   Munkholm K, 2013, J AFFECT DISORDERS, V144, P16, DOI 10.1016/j.jad.2012.06.010
   Nierenberg AA, 2018, BIOL PSYCHIAT, V83, P761, DOI 10.1016/j.biopsych.2017.12.014
   Oy B., 1991, Turk Psikiyatri Dergisi, V2, P132, DOI DOI 10.1016/J.BIOPSYCH.2017.12.014
   Park J, 2010, J KOREAN MED SCI, V25, P75, DOI 10.3346/jkms.2010.25.1.75
   Perugi G, 2015, J AFFECT DISORDERS, V170, P95, DOI 10.1016/j.jad.2014.08.052
   Regenold WT, 2002, J AFFECT DISORDERS, V70, P19, DOI 10.1016/S0165-0327(01)00456-6
   Rolland B, 2013, CURR DRUG TARGETS, V14, P724, DOI 10.2174/1389450111314070002
   Rosenblat JD, 2017, BRAIN SCI, V7, DOI 10.3390/brainsci7110144
   Rosenblat JD, 2016, BIPOLAR DISORD, V18, P89, DOI 10.1111/bdi.12373
   Rosenblat JD, 2014, PROG NEURO-PSYCHOPH, V53, P23, DOI 10.1016/j.pnpbp.2014.01.013
   Sakamoto Y, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0149676
   Salvi V, 2012, J AFFECT DISORDERS, V136, P599, DOI 10.1016/j.jad.2011.10.025
   Tufano M, 2020, MOLECULES, V25, DOI 10.3390/molecules25051062
   Ünal F, 2019, TURK PSIKIYATR DERG, V30, P42, DOI 10.5080/u23408
   van den Ameele S, 2016, J AFFECT DISORDERS, V203, P364, DOI 10.1016/j.jad.2016.06.016
   Van Meter A, 2019, J CLIN PSYCHIAT, V80, DOI 10.4088/JCP.18r12180
   Wadee AA, 2002, HUM PSYCHOPHARM CLIN, V17, P175, DOI 10.1002/hup.390
   YOUNG RC, 1978, BRIT J PSYCHIAT, V133, P429, DOI 10.1192/bjp.133.5.429
   Yüksel RN, 2019, ASIAN J PSYCHIATR, V46, P24, DOI 10.1016/j.ajp.2019.09.026
   Zeinoddini A, 2015, DEPRESS ANXIETY, V32, P167, DOI 10.1002/da.22340
   Zimmet P, 2007, PEDIATR DIABETES, V8, P299, DOI 10.1111/j.1399-5448.2007.00271.x
NR 51
TC 3
Z9 3
U1 0
U2 3
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0895-8696
EI 1559-1166
J9 J MOL NEUROSCI
JI J. Mol. Neurosci.
PD JUN
PY 2022
VL 72
IS 6
BP 1313
EP 1321
DI 10.1007/s12031-022-02000-2
EA MAR 2022
PG 9
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 1W5WY
UT WOS:000771845600001
PM 35318563
DA 2025-06-11
ER

PT J
AU Weiner, M
   Warren, L
   Fiedorowicz, JG
AF Weiner, Miriam
   Warren, Lois
   Fiedorowicz, Jess G.
TI Cardiovascular morbidity and mortality in bipolar disorder
SO ANNALS OF CLINICAL PSYCHIATRY
LA English
DT Article
DE bipolar disorder; cardiovascular disease; mortality; metabolic syndrome;
   obesity; hypertension
ID MANIC-DEPRESSIVE PATIENTS; CIVIL STATE HOSPITALS; METABOLIC SYNDROME;
   DIABETES-MELLITUS; RISK-FACTORS; WEIGHT-GAIN; ATYPICAL ANTIPSYCHOTICS;
   PSYCHIATRIC-PATIENTS; 1ST ADMISSIONS; SCHIZOAFFECTIVE DISORDER
AB BACKGROUND: There has been considerable interest in the elevated risk of cardiovascular disease associated with serious mental illness. Although the contemporary literature has paid much attention to major depression and schizophrenia, focus on the risk of cardiovascular mortality for patients with bipolar disorder has been more limited, despite some interest in the historical literature.
   METHODS: We reviewed the historical and contemporary literature related to cardiovascular morbidity and mortality in bipolar disorder.
   RESULTS: In studies that specifically assess cardiovascular mortality, bipolar disorder has been associated with a near doubling of risk when compared with general population estimates. This may be explained by the elevated burden of cardiovascular risk factors found in this population. These findings predate modern treatments for bipolar disorder, which may further influence cardiovascular risk.
   CONCLUSIONS: Given the substantial risk of cardiovascular disease, rigorous assessment of cardiovascular risk is warranted for patients with bipolar disorder. Modifiable risk factors should be treated when identified. Further research is warranted to study mechanisms by which this elevated risk for cardiovascular disease are mediated and to identify systems for effective delivery of integrated medical and psychiatric care for individuals with bipolar disorder.
C1 [Fiedorowicz, Jess G.] Univ Iowa, Coll Publ Hlth, Dept Epidemiol, Dept Psychiat,Carver Coll Med, Iowa City, IA 52242 USA.
C3 University of Iowa
RP Fiedorowicz, JG (corresponding author), Univ Iowa, Coll Publ Hlth, Dept Epidemiol, Dept Psychiat,Carver Coll Med, 200 Hawkins Dr,W278GH, Iowa City, IA 52242 USA.
EM jess-fiedorowicz@uiowa.edu
RI Fiedorowicz, Jess/I-2512-2019
OI Fiedorowicz, Jess/0000-0003-2057-4071
FU National Institute of Mental Health [1K23MH083695-01A210]; Nellie Ball
   Trust; NARSAD; Institute for Clinical and Translational Science at the
   University of Iowa [3 UL1 RR024979-03S4]; Eli Lilly and Company
FX Dr. Fiedorowicz is supported by the National Institute of Mental Health
   (1K23MH083695-01A210), the Nellie Ball Trust Research Fund, and a NARSAD
   Young Investigator Award, and the Institute for Clinical and
   Translational Science at the University of Iowa (3 UL1 RR024979-03S4).
   Dr. Fiedorowicz currently serves on colleagues' studies with
   Neurosearch, Vitalin/Enzymatic Therapy, and the National Center for
   Complementary and Alternative Medicine/Food and Drug Administration
   Orphan Products division. He also has received research support for
   participating in a colleague's investigator-initiated study with Eli
   Lilly and Company. Ms. Weiner and Ms. Warren report no financial
   relationship with any company whose products are mentioned in this
   article, or with manufacturers of competing products.
CR Adland ML, 1947, PSYCHIAT QUART, V21, P38, DOI 10.1007/BF01674767
   Alstrom C.H., 1942, ACTA PSYCH NEUROL, V17, P1
   Angst F, 2002, J AFFECT DISORDERS, V68, P167, DOI 10.1016/S0165-0327(01)00377-9
   BABIGIAN HM, 1969, AM J PSYCHIAT, V126, P470, DOI 10.1176/ajp.126.4.470
   Bell L., 1849, American Journal of Insanity, V6, P97
   BERKSON J, 1980, BRIT J PSYCHIAT, V136, P239
   Birkenaes AB, 2007, J CLIN PSYCHIAT, V68, P917, DOI 10.4088/JCP.v68n0614
   BLACK DW, 1985, ARCH GEN PSYCHIAT, V42, P82
   BRANDRUP E, 1967, BRIT J PSYCHIAT, V113, P987, DOI 10.1192/bjp.113.502.987
   BUMKE O, 1928, HDB GEISTESKRANKHEIT
   Cardenas J, 2008, J AFFECT DISORDERS, V106, P91, DOI 10.1016/j.jad.2007.05.030
   Carlson C, 2006, EUR NEUROPSYCHOPHARM, V16, P366, DOI 10.1016/j.euroneuro.2005.11.002
   Cassidy F, 1999, AM J PSYCHIAT, V156, P1417
   Craig TJ, 2006, COMPR PSYCHIAT, V47, P248, DOI 10.1016/j.comppsych.2005.11.004
   De Hert M, 2006, Clin Pract Epidemiol Ment Health, V2, P14
   Derby IM, 1933, PSYCHIAT QUART, V7, P436, DOI 10.1007/BF01563541
   DINESEN H, 1984, ACTA NEUROL SCAND, V70, P65
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   Fiedorowicz JG, 2008, ANN CLIN PSYCHIATRY, V20, P131, DOI 10.1080/10401230802177722
   Garcia-Portilla MP, 2008, J AFFECT DISORDERS, V106, P197, DOI 10.1016/j.jad.2007.06.002
   Gaulin BD, 1999, AM J PSYCHIAT, V156, P1270
   Gianfrancesco F, 2003, J CLIN PSYCHOPHARM, V23, P328, DOI 10.1097/01.jcp.0000085404.08426.3a
   Guo JJ, 2006, J CLIN PSYCHIAT, V67, P1055, DOI 10.4088/JCP.v67n0707
   Henderson DC, 2000, AM J PSYCHIAT, V157, P975, DOI 10.1176/appi.ajp.157.6.975
   HERMIDA OG, 1994, BRIT J PHARMACOL, V111, P861, DOI 10.1111/j.1476-5381.1994.tb14817.x
   Huang TL, 2005, SCHIZOPHR RES, V80, P55, DOI 10.1016/j.schres.2005.05.001
   Johannessen L, 2006, J AFFECT DISORDERS, V95, P13, DOI 10.1016/j.jad.2006.03.027
   Kallner G, 2000, PHARMACOPSYCHIATRY, V33, P8, DOI 10.1055/s-2000-7965
   Kasanin J, 1926, ARCH NEURO PSYCHIATR, V16, P414, DOI 10.1001/archneurpsyc.1926.02200280022002
   Kilbourne AM, 2004, BIPOLAR DISORD, V6, P368, DOI 10.1111/j.1399-5618.2004.00138.x
   Kilbourne AM, 2007, J AFFECT DISORDERS, V102, P145, DOI 10.1016/j.jad.2007.01.006
   Kilbourne AM, 2007, BIPOLAR DISORD, V9, P443, DOI 10.1111/j.1399-5618.2007.00386.x
   Kraepelin E, 1921, MANIC DEPRESSIVE INS
   Kreyenbuhl J, 2006, J NERV MENT DIS, V194, P404, DOI 10.1097/01.nmd.0000221177.51089.7d
   Lambert BL, 2005, PHARMACOEPIDEM DR S, V14, P417, DOI 10.1002/pds.1092
   Lasser K, 2000, JAMA-J AM MED ASSOC, V284, P2606, DOI 10.1001/jama.284.20.2606
   Laursen TM, 2007, J CLIN PSYCHIAT, V68, P899, DOI 10.4088/JCP.v68n0612
   Malzberg B, 1952, MENT HYG, V36, P104
   Malzberg B, 1952, MENT HYG, V36, P618
   Malzberg B, 1953, MENT HYG, V37, P619
   MARTIN RL, 1985, ARCH GEN PSYCHIAT, V42, P58
   MARTIN RL, 1985, PSYCHIAT DEV, V3, P317
   McElroy SL, 2002, J CLIN PSYCHIAT, V63, P207, DOI 10.4088/JCP.v63n0306
   Meloni D, 2006, PSYCHIAT SERV, V57, P1474, DOI 10.1176/appi.ps.57.10.1474
   Merikangas KR, 2007, CURR OPIN PSYCHIATR, V20, P353, DOI 10.1097/YCO.0b013e3281c61dc5
   MULLEROERLINGHAUSEN B, 1994, ACTA PSYCHIAT SCAND, V90, P295, DOI 10.1111/j.1600-0447.1994.tb01596.x
   ODEGARD ORNULF, 1951, ACTA GENET ET STATIST MED, V2, P141
   Ollendorf Daniel A, 2004, MedGenMed, V6, P5
   Ösby U, 2001, ARCH GEN PSYCHIAT, V58, P844, DOI 10.1001/archpsyc.58.9.844
   Osser DN, 1999, J CLIN PSYCHIAT, V60, P767, DOI 10.4088/JCP.v60n1109
   PERRIS C, 1966, ACTA PSYCHIAT SCAND, VS 42, P172
   Pylvänen V, 2002, EPILEPSIA, V43, P514, DOI 10.1046/j.1528-1157.2002.31501.x
   Raphael T, 1921, ARCH NEURO PSYCHIATR, V5, P687, DOI 10.1001/archneurpsyc.1921.02180300052005
   RAY I, 1853, AM J INSANITY, V10, P95
   Teixeira PJR, 2007, REV BRAS PSIQUIATR, V29, P330, DOI 10.1590/S1516-44462007000400007
   RORSMAN B, 1974, ACTA PSYCHIAT SCAND, V50, P354, DOI 10.1111/j.1600-0447.1974.tb08221.x
   Sachs G, 2006, BIPOLAR DISORD, V8, P175, DOI 10.1111/j.1399-5618.2006.00308.x
   Sernyak MJ, 2005, J CLIN PSYCHIAT, V66, P1463, DOI 10.4088/JCP.v66n1117
   Shah Amy, 2006, Ann Clin Psychiatry, V18, P239, DOI 10.1080/10401230600948423
   SHARMA R, 1994, J AFFECT DISORDERS, V31, P91, DOI 10.1016/0165-0327(94)90112-0
   Simpson GM, 2005, AM J MANAG CARE, V11, pS235
   SIMS A, 1978, BRIT J PSYCHIAT, V133, P299, DOI 10.1192/bjp.133.4.299
   Slater E, 1938, Z GESAMTE NEUROL PSY, V163, P1, DOI 10.1007/BF02868355
   Spivak B, 1999, CLIN NEUROPHARMACOL, V22, P98, DOI 10.1097/00002826-199903000-00006
   Tsai SY, 2005, J CLIN PSYCHIAT, V66, P1586, DOI 10.4088/JCP.v66n1215
   van Winkel R, 2008, BIPOLAR DISORD, V10, P342, DOI 10.1111/j.1399-5618.2007.00520.x
   VENDSBORG PB, 1976, ACTA PSYCHIAT SCAND, V53, P139, DOI 10.1111/j.1600-0447.1976.tb00067.x
   VESTERGAARD P, 1991, J AFFECT DISORDERS, V21, P33, DOI 10.1016/0165-0327(91)90016-L
   Volavka J, 2002, AM J PSYCHIAT, V159, P255, DOI 10.1176/appi.ajp.159.2.255
   WEEKE A, 1986, J AFFECT DISORDERS, V11, P227, DOI 10.1016/0165-0327(86)90074-1
   WEEKE A, 1987, J AFFECT DISORDERS, V13, P287, DOI 10.1016/0165-0327(87)90049-8
   YATES WR, 1987, J AFFECT DISORDERS, V12, P129, DOI 10.1016/0165-0327(87)90004-8
   Yumru M, 2007, J AFFECT DISORDERS, V98, P247, DOI 10.1016/j.jad.2006.08.009
   ZILBER N, 1989, ACTA PSYCHIAT SCAND, V79, P248, DOI 10.1111/j.1600-0447.1989.tb10254.x
   Zipursky RB, 2005, BRIT J PSYCHIAT, V187, P537, DOI 10.1192/bjp.187.6.537
NR 75
TC 177
Z9 189
U1 1
U2 18
PU QUADRANT HEALTHCOM INC
PI PARSIPPANY
PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA
SN 1040-1237
EI 1547-3325
J9 ANN CLIN PSYCHIATRY
JI Ann. Clin. Psychiatry
PD FEB
PY 2011
VL 23
IS 1
BP 40
EP 47
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 725AB
UT WOS:000287616500007
PM 21318195
DA 2025-06-11
ER

PT J
AU Grandner, MA
   Winkelman, JW
AF Grandner, Michael A.
   Winkelman, John W.
TI Nocturnal leg cramps: Prevalence and associations with demographics,
   sleep disturbance symptoms, medical conditions, and cardiometabolic risk
   factors
SO PLOS ONE
LA English
DT Article
ID MUSCLE CRAMPS
AB Background
   Nocturnal leg cramps (NLC) are common and poorly understood.
   Objective
   To determine the prevalence of NLC and associations with cardiometabolic, sleep, and behavioral risk factors in the US population.
   Design
   Cross-sectional epidemiology.
   Participants
   National Health and Nutrition Examination Survey, 2005-2006 and 2007-2008 waves.
   Main outcome(s) and measure(s)
   NLC were assessed with, "In the past month, how often did you have leg cramps while trying to sleep?" Responses were categorized as None, Mild, or Moderate-Severe. Demographics, medical history, sleep disturbances, and cardiometabolic risk factors were evaluated using the 2005-2006 dataset. Variables that demonstrated significant relationships to NLC after adjusting for age, sex, education, and BMI were assessed in the 2007-2008 dataset. Variables that were still significant were entered into a forward stepwise regression model combining both waves, to determine which variables best explained the variance in NLC.
   Results
   Prevalence was 24-25% reporting mild and 6% reporting moderate-severe NLC. NLC increased with age, lower education, unemployment, shorter sleep duration, all assessed sleep symptoms (nocturnal "leg jerks", snoring, snorting/gasping, difficulty falling asleep, difficulty maintaining sleep, non-restorative sleep, sleepiness, use of sleep medications), higher BMI, smoking, medical history (hypertension, heart failure, angina, stroke, arthritis, respiratory disease, and cancer), depression symptoms, and biomarkers (CRP, HbA1c, calcium, cadmium, red blood cells). Stepwise analysis showed that moderate-severe nocturnal leg cramps were associated with (in decreasing order of partial R-2): leg jerks, poor overall health, arthritis, difficulty falling asleep, age, nonrestorative sleep, red blood cell count, lower education, angina, and difficulty maintaining sleep.
   Conclusions and relevance
   Based on this first large, representative study, NLC occurring >5x per month are reported by 6% of the adult US population. Sleep disturbance symptoms and health conditions are associated with higher frequency of NLC, suggesting that NLC is a marker, and possibly contributor, to poor sleep and general health.
C1 [Grandner, Michael A.] Univ Arizona, Dept Psychiat, Tucson, AZ USA.
   [Winkelman, John W.] Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02115 USA.
   [Winkelman, John W.] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02115 USA.
C3 University of Arizona; Harvard University; Harvard Medical School;
   Harvard University Medical Affiliates; Massachusetts General Hospital;
   Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard Medical School
RP Winkelman, JW (corresponding author), Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02115 USA.; Winkelman, JW (corresponding author), Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02115 USA.
EM jwwinkelman@partners.org
OI Grandner, Michael/0000-0002-4626-754X
FU National Heart, Lung, and Blood Institute [K23HL110216]; Luitpold
   Pharmaceuticals; Xenoport; UCB Pharma; NeuroMetrix; NIMH
FX This work received support from the National Heart, Lung, and Blood
   Institute, Grant number: K23HL110216, URL: https://www.nhlbi.nih.gov/.
   Author who received funding: MG. The funder had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.The authors wish to thank Dr. Susan Redline for her
   contributions to editing the manuscript, as well as Nicholas Jackson for
   input on statistical models. Dr. Winkelman is a consultant for Merck and
   Flex Pharma, has provided expert testimony for Cantor Colburn, receives
   royalties from UpToDate, and has received research grants from Luitpold
   Pharmaceuticals, Xenoport, UCB Pharma, NeuroMetrix, and NIMH. Dr.
   Grandner is a consultant for FitBit and is on the Scientific Advisory
   Board for CurAegis Technologies. He has provided expert testimony for
   Morrison Foerster. This abstract was presented at the 2016 APSS SLEEP
   meeting.
CR Abdulla AJJ, 1999, INT J CLIN PRACT, V53, P494
   Allen RP, 2005, ARCH INTERN MED, V165, P1286, DOI 10.1001/archinte.165.11.1286
   American Academy of Sleep Medicine, 2014, THE INTERNATIONAL CL
   [Anonymous], 2008, NAT HLTH NUTR EX SUR
   Brown TM, 2015, SLEEP MED CLIN, V10, P385, DOI 10.1016/j.jsmc.2015.05.002
   Garrison SR, 2012, ARCH INTERN MED, V172, P120, DOI 10.1001/archinternmed.2011.1029
   Gottlieb DJ, 2016, SLEEP MED
   HALL AJ, 1947, LANCET, V253, P231
   Hawke F, 2013, QUAL LIFE RES, V22, P1281, DOI 10.1007/s11136-012-0274-8
   Hawke F, 2013, MUSCLE NERVE, V47, P339, DOI 10.1002/mus.23531
   Hornyak M, 2006, SLEEP MED REV, V10, P169, DOI 10.1016/j.smrv.2005.12.003
   JANSEN PHP, 1991, J NEUROL NEUROSUR PS, V54, P1124, DOI 10.1136/jnnp.54.12.1124
   Jansen PHP, 1999, J EUR ACAD DERMATOL, V12, P222, DOI 10.1016/S0926-9959(99)00041-0
   Katzberg H, 2014, DIABETES CARE, V37, pE17, DOI 10.2337/dc13-1163
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   NAYLOR JR, 1994, AGE AGEING, V23, P418, DOI 10.1093/ageing/23.5.418
   OBOLER SK, 1991, WESTERN J MED, V155, P256
   Rabbitt L, 2016, AGE AGEING, V45, P776, DOI 10.1093/ageing/afw139
   Winkelman JW, 2011, UPTO DATE
NR 19
TC 21
Z9 25
U1 0
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 6
PY 2017
VL 12
IS 6
AR e0178465
DI 10.1371/journal.pone.0178465
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EW9YQ
UT WOS:000402875700013
PM 28586374
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Peng, L
   Di, XP
   He, SX
   Zeng, X
   Shen, H
   Zhu, HL
   Luo, DY
AF Peng, Liao
   Di, Xing-peng
   He, Shi-xin
   Zeng, Xiao
   Shen, Hong
   Zhu, Hui-li
   Luo, De-yi
TI Metabolic syndrome in women with and without interstitial
   cystitis/bladder pain syndrome
SO INTERNATIONAL UROGYNECOLOGY JOURNAL
LA English
DT Article
DE Metabolic syndrome; Obesity; Body mass index; Interstitial cystitis;
   bladder pain syndrome
ID URINARY-TRACT SYMPTOMS; SYNDROME/INTERSTITIAL CYSTITIS;
   DIABETES-MELLITUS; BLADDER PAIN; INCONTINENCE; RISK; CHOLESTEROL;
   PREVALENCE; INSULIN; IMPACT
AB Introduction and hypothesis The aim of this study was to compare the frequency of metabolic syndrome (MetS) in patients with and without interstitial cystitis/bladder pain syndrome (IC/BPS). Methods This case-control study evaluated the indicators of MetS in 287 females with IC/BPS and in 287 females without IC/BPS in West China Hospital between January 2010 and January 2020. Then, the number of voids per day, frequency of night urination, O'Leary-Sant Interstitial Cystitis Symptom/Problem Index, and visual analog scale were examined in the two groups. Results Based on both the National Cholesterol Education Program Adult Treatment Panel III recommendations and the International Diabetes Federation criteria, the distribution of MetS was statistically higher in patients with IC/BPS than in the control group, with 34.8% vs 17.8% (P < 0.0001) and 34.2% vs 20.9% (P = 0.0005), respectively. Regarding symptom scores, the IC/BPS group demonstrated significantly higher scores than the control group in all aspects (P < 0.0001). More patients with anxiety (P < 0.0001), insomnia (P < 0.0001), hypertension (P = 0.0001), and diabetes mellitus (P = 0.017) were observed in the IC/BPS group. Moreover, the findings indicated that patients with IC/BPS had a higher BMI (P = 0.0001) and larger waist circumference (P = 0.0001). Blood tests presented a significantly higher level of fasting glycemia, serum cystatin-C, and triglycerides in patients with IC/BPS. Furthermore, higher ORs for the occurrence of MetS among cases were observed, although this was not statistically significant. Conclusions MetS frequency was relatively high in patients with IC/BPS. Further research is needed to understand the common pathophysiologic mechanism of IC/BPS and MetS.
C1 [Peng, Liao; Di, Xing-peng; Zeng, Xiao; Shen, Hong; Luo, De-yi] Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, 37 Guo Xue Xiang, Chengdu 610041, Sichuan, Peoples R China.
   [He, Shi-xin] Chengdu Med Coll, Affiliated Hosp 1, Dept Dermatol, Xindu, Sichuan, Peoples R China.
   [Zhu, Hui-li] Sichuan Univ, West China Univ Hosp 2, Dept Obstet & Gynecol, 20,Sect 3,Renmin Nan Lu, Chengdu 610041, Sichuan, Peoples R China.
C3 Sichuan University; Chengdu Medical College; Sichuan University
RP Luo, DY (corresponding author), Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, 37 Guo Xue Xiang, Chengdu 610041, Sichuan, Peoples R China.; Zhu, HL (corresponding author), Sichuan Univ, West China Univ Hosp 2, Dept Obstet & Gynecol, 20,Sect 3,Renmin Nan Lu, Chengdu 610041, Sichuan, Peoples R China.
EM 13551287548@163.com; luodeyi1985@163.com
RI Zeng, Xiao/ABG-5938-2021; Di, Xingpeng/HKN-5814-2023
OI Di, Xingpeng/0000-0002-1921-5509
FU National Natural Science Fund of China [81770673]; 1.3.5 Project for
   Disciplines of Excellence, West China Hospital, Sichuan University
   [ZY2017310]; Project of Science and Technology Department of Sichuan
   Province [2018SZ0177, 2018SZ0055]; Foundation of Science and Technology
   Department of Sichuan Province [2019YFS0281]
FX This study was funded by the National Natural Science Fund of China
   (grant no. 81770673), 1.3.5 Project for Disciplines of Excellence, West
   China Hospital, Sichuan University (grant no. ZY2017310), Project of
   Science and Technology Department of Sichuan Province (2018SZ0177,
   2018SZ0055), and Foundation of Science and Technology Department of
   Sichuan Province (2019YFS0281).
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   [Anonymous], 2004, DIABETES CARE S1, V27, pS5, DOI DOI 10.2337/diacare.27.2007.s15
   Chuang YC, 2015, INT UROL NEPHROL, V47, P275, DOI 10.1007/s11255-014-0908-6
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Dallosso H, 2004, EUR J CLIN NUTR, V58, P920, DOI 10.1038/sj.ejcn.1601913
   DeBose-Boyd RA, 2018, SEMIN CELL DEV BIOL, V81, P97, DOI 10.1016/j.semcdb.2017.12.003
   Dellis AE, 2018, EXPERT OPIN PHARMACO, V19, P1369, DOI 10.1080/14656566.2018.1505865
   de Oliveira MCE, 2016, DIABET METAB SYND OB, V9, P207, DOI 10.2147/DMSO.S106221
   Hanno PM, 1999, J UROLOGY, V161, P553, DOI 10.1016/S0022-5347(01)61948-7
   Hill SR, 2008, NEUROUROL URODYNAM, V27, P362, DOI 10.1002/nau.20533
   Homma Y, 2020, INT J UROL, V27, P578, DOI 10.1111/iju.14234
   Jhang JF, 2016, INT NEUROUROL J, V20, P95, DOI 10.5213/inj.1632712.356
   KOZIOL JA, 1993, J UROLOGY, V149, P465, DOI 10.1016/S0022-5347(17)36120-7
   Kuo HC, 2015, NEUROUROL URODYNAM, V34, P685, DOI 10.1002/nau.22645
   Lai HH, 2019, UROLOGY, V123, P34, DOI 10.1016/j.urology.2018.09.012
   Lamerton TJ, 2018, OBES REV, V19, P1735, DOI 10.1111/obr.12756
   Laven BA, 2008, J UROLOGY, V179, P1891, DOI 10.1016/j.juro.2008.01.029
   Lee EJ, 2011, AM J OBSTET GYNECOL, V204, pS107, DOI 10.1016/j.ajog.2010.10.270
   Maserejian NN, 2010, AM J EPIDEMIOL, V171, P1116, DOI 10.1093/aje/kwq065
   Maserejian NN, 2009, EUR UROL, V55, P1179, DOI 10.1016/j.eururo.2008.07.058
   Ströher RLM, 2020, INT UROGYNECOL J, V31, P173, DOI 10.1007/s00192-019-03880-6
   Ogawa T, 2018, EXPERT REV CLIN PHAR, V11, P495, DOI 10.1080/17512433.2018.1457435
   OLeary MP, 1997, UROLOGY, V49, P58, DOI 10.1016/S0090-4295(99)80333-1
   Otunctemur A, 2014, INT UROL NEPHROL, V46, P1501, DOI 10.1007/s11255-014-0680-7
   Papaefstathiou E, 2019, DIABETES METAB SYND, V13, P454, DOI 10.1016/j.dsx.2018.11.009
   Patnaik SS, 2017, ARCH GYNECOL OBSTET, V295, P1341, DOI 10.1007/s00404-017-4364-2
   Pirro M, 2018, PROG LIPID RES, V71, P54, DOI 10.1016/j.plipres.2018.06.001
   Russo GI, 2014, J SEX MED, V11, P2074, DOI 10.1111/jsm.12587
   Scherrer U, 1997, CIRCULATION, V96, P4104
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Tai HC, 2010, J CLIN ENDOCR METAB, V95, P1143, DOI 10.1210/jc.2009-1492
   Temml C, 2007, EUR UROL, V51, P803, DOI 10.1016/j.eururo.2006.08.028
   Uzun H, 2012, UROLOGY, V79, P72, DOI 10.1016/j.urology.2011.08.050
   van de Merwe JP, 2008, EUR UROL, V53, P60, DOI 10.1016/j.eururo.2007.09.019
   Wang YL, 2015, INT UROGYNECOL J, V26, P911, DOI 10.1007/s00192-015-2626-8
   Zacche MM, 2017, EUR J OBSTET GYN R B, V217, P1, DOI 10.1016/j.ejogrb.2017.08.002
NR 36
TC 6
Z9 6
U1 0
U2 4
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 0937-3462
EI 1433-3023
J9 INT UROGYNECOL J
JI Int. Urogynecol. J.
PD MAY
PY 2021
VL 32
IS 5
BP 1299
EP 1306
DI 10.1007/s00192-020-04605-w
EA NOV 2020
PG 8
WC Obstetrics & Gynecology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Urology & Nephrology
GA SF9XU
UT WOS:000590948100001
PM 33215272
DA 2025-06-11
ER

PT J
AU Susic, D
   Varagic, J
AF Susic, Dinko
   Varagic, Jasmina
TI Obesity A Perspective from Hypertension
SO MEDICAL CLINICS OF NORTH AMERICA
LA English
DT Article
DE Obesity; Hypertension; Sodium; Sympathetic nervous system;
   Renin-angiotensin-aldosterone system; Insulin resistance; Adipokines
ID BODY-MASS-INDEX; SYMPATHETIC-NERVOUS-SYSTEM; CARDIOMETABOLIC
   RISK-FACTORS; SELECTIVE LEPTIN RESISTANCE; TYPE-2 DIABETES-MELLITUS;
   INTIMA-MEDIA THICKNESS; BLOOD-PRESSURE CONTROL; CHRONIC KIDNEY-DISEASE;
   ADIPOSE-TISSUE MASS; WEIGHT-LOSS
AB The prevalence of obesity-related hypertension is high worldwide and has become a major health issue. The mechanisms by which obesity relates to hypertensive disease are still under intense research scrutiny, and include altered hemodynamics, impaired sodium homeostasis, renal dysfunction, autonomic nervous system imbalance, endocrine alterations, oxidative stress and inflammation, and vascular injury. Most of these contributing factors interact with each other at multiple levels. Thus, as a multifactorial and complex disease, obesity-related hypertension should be recognized as a distinctive form of hypertension, and specific considerations should apply in planning therapeutic approaches to treat obese individuals with high blood pressure.
C1 [Susic, Dinko] Ochsner Clin Fdn, Hypertens Res Lab, 1514 Jefferson Highway, New Orleans, LA 70121 USA.
   [Varagic, Jasmina] Wake Forest Sch Med, Hypertens & Vasc Res, Dept Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
   [Varagic, Jasmina] Wake Forest Sch Med, Dept Physiol & Pharmacol, Med Ctr Blvd, Winston Salem, NC 27157 USA.
C3 Ochsner Health System; Wake Forest University; Wake Forest University
RP Varagic, J (corresponding author), Wake Forest Sch Med, Hypertens & Vasc Res, Dept Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM jvaragic@wakehealth.edu
CR AlonsoGalicia M, 1996, HYPERTENSION, V28, P1047, DOI 10.1161/01.HYP.28.6.1047
   Amann K, 2013, SEMIN NEPHROL, V33, P23, DOI 10.1016/j.semnephrol.2012.12.003
   ANDERSON EA, 1992, HYPERTENSION, V19, P621, DOI 10.1161/01.HYP.19.6.621
   [Anonymous], 1998, OBES RES S2, V6, p51S
   Appel LJ, 2006, HYPERTENSION, V47, P296, DOI 10.1161/01.HYP.0000202568.01167.B6
   ARONNE LJ, 1995, AM J PHYSIOL-REG I, V269, pR222, DOI 10.1152/ajpregu.1995.269.1.R222
   Aroor Annayya R, 2013, Front Endocrinol (Lausanne), V4, P161, DOI 10.3389/fendo.2013.00161
   Aroor AR, 2012, HEART FAIL CLIN, V8, P609, DOI 10.1016/j.hfc.2012.06.005
   Asferg CL, 2013, HYPERTENSION, V62, P147, DOI 10.1161/HYPERTENSIONAHA.111.00791
   Bentley-Lewis R, 2007, J CLIN ENDOCR METAB, V92, P4472, DOI 10.1210/jc.2007-1088
   Black HR, 2001, HYPERTENSION, V37, P12, DOI 10.1161/01.HYP.37.1.12
   Blanco-Rivero J, 2005, HYPERTENSION, V46, P107, DOI 10.1161/01.HYP.0000171479.36880.17
   Boustany CM, 2005, AM J PHYSIOL-REG I, V289, pR181, DOI 10.1152/ajpregu.00507.2004
   Brown CD, 2000, OBES RES, V8, P605, DOI 10.1038/oby.2000.79
   Burton JO, 2012, NEPHROL DIAL TRANSPL, V27, P1860, DOI 10.1093/ndt/gfr574
   Byrd JB, 2014, J HUM HYPERTENS, V28, P3, DOI 10.1038/jhh.2013.42
   Calhoun DA, 2013, ANNU REV MED, V64, P233, DOI 10.1146/annurev-med-042711-135929
   Cancello R, 2006, DIABETES, V55, P1554, DOI 10.2337/db06-0133
   Cao Y, 2009, J MOL CELL CARDIOL, V46, P413, DOI 10.1016/j.yjmcc.2008.10.014
   Carlyle M, 2002, HYPERTENSION, V39, P496, DOI 10.1161/hy0202.104398
   Cavalcante JL, 2011, J AM COLL CARDIOL, V57, P1511, DOI 10.1016/j.jacc.2010.12.017
   Chae CU, 2001, HYPERTENSION, V38, P399, DOI 10.1161/01.HYP.38.3.399
   Chandra A, 2014, J AM COLL CARDIOL, V64, P997, DOI 10.1016/j.jacc.2014.05.057
   Chen XL, 2008, CIRCULATION, V117, P3171, DOI 10.1161/CIRCULATIONAHA.107.730366
   Chughtai HL, 2010, HYPERTENSION, V56, P901, DOI 10.1161/HYPERTENSIONAHA.110.157370
   Considine RV, 1996, NEW ENGL J MED, V334, P292, DOI 10.1056/NEJM199602013340503
   Correia MLG, 2002, DIABETES, V51, P439, DOI 10.2337/diabetes.51.2.439
   Cushman William C, 2002, J Clin Hypertens (Greenwich), V4, P393
   Dahlöf B, 2002, LANCET, V359, P995, DOI 10.1016/S0140-6736(02)08089-3
   Dall'Asta C, 2009, NUTR METAB CARDIOVAS, V19, P110, DOI 10.1016/j.numecd.2008.06.001
   Davy KP, 2004, AM J PHYSIOL-REG I, V286, pR803, DOI 10.1152/ajpregu.00707.2003
   De Marco M, 2009, HYPERTENSION, V54, P974, DOI 10.1161/HYPERTENSIONAHA.109.129031
   de Paula RB, 2004, HYPERTENSION, V43, P41, DOI 10.1161/01.HYP.0000105624.68174.00
   de Souza F, 2010, HYPERTENSION, V55, P147, DOI 10.1161/HYPERTENSIONAHA.109.140988
   deCourten M, 1997, DIABETIC MED, V14, P200, DOI 10.1002/(SICI)1096-9136(199703)14:3<200::AID-DIA336>3.0.CO;2-V
   Dickinson KM, 2014, ATHEROSCLEROSIS, V233, P32, DOI 10.1016/j.atherosclerosis.2013.11.078
   Dorresteijn JAN, 2013, J HYPERTENS, V31, P393, DOI 10.1097/HJH.0b013e32835b6c02
   Droyvold WB, 2005, INT J OBESITY, V29, P650, DOI 10.1038/sj.ijo.0802944
   Eckel RH, 2014, J AM COLL CARDIOL, V63, P2960, DOI 10.1016/j.jacc.2013.11.003
   Elliott P, 1996, BMJ-BRIT MED J, V312, P1249, DOI 10.1136/bmj.312.7041.1249
   Engeli S, 2001, J MOL MED, V79, P21, DOI 10.1007/s001090000144
   Engeli S, 2000, HYPERTENSION, V35, P1270, DOI 10.1161/01.HYP.35.6.1270
   Esler M, 2006, HYPERTENSION, V48, P787, DOI 10.1161/01.HYP.0000242642.42177.49
   Esler MD, 2010, LANCET, V376, P1903, DOI 10.1016/S0140-6736(10)62039-9
   Faber DR, 2010, ATHEROSCLEROSIS, V212, P274, DOI 10.1016/j.atherosclerosis.2010.04.029
   Femia R, 2007, ARTERIOSCL THROM VAS, V27, P2244, DOI 10.1161/ATVBAHA.107.149641
   Ferrario CM, 2010, LIFE SCI, V86, P289, DOI 10.1016/j.lfs.2009.11.020
   Foster MC, 2011, HYPERTENSION, V58, P784, DOI 10.1161/HYPERTENSIONAHA.111.175315
   Freedman DS, 1999, PEDIATRICS, V103, P1175, DOI 10.1542/peds.103.6.1175
   FRIEDMAN SM, 1990, J HYPERTENS, V8, P61, DOI 10.1097/00004872-199001000-00010
   FRIEDMAN SM, 1990, J HYPERTENS, V8, P67, DOI 10.1097/00004872-199001000-00011
   FROHLICH ED, 1983, HYPERTENSION, V5, P71
   Frohlich Edward D, 2002, Cardiol Rev, V10, P127, DOI 10.1097/00045415-200205000-00001
   Frohlich Edward D., 1991, Annals of Epidemiology, V1, P287
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Garg R, 2014, DIABETES OBES METAB, V16, P268, DOI 10.1111/dom.12224
   Garg R, 2010, J CLIN ENDOCR METAB, V95, P1986, DOI 10.1210/jc.2009-2521
   GARRISON RJ, 1987, PREV MED, V16, P235, DOI 10.1016/0091-7435(87)90087-9
   Gletsu-Miller N, 2009, OBESITY, V17, P439, DOI 10.1038/oby.2008.542
   GORDON T, 1976, CLIN ENDOCRINOL META, V5, P367, DOI 10.1016/S0300-595X(76)80026-6
   Grassi G, 2000, HYPERTENSION, V36, P538, DOI 10.1161/01.HYP.36.4.538
   GRASSI G, 1995, HYPERTENSION, V25, P560, DOI 10.1161/01.HYP.25.4.560
   Grassi G, 2003, J HYPERTENS, V21, P1761, DOI 10.1097/00004872-200309000-00027
   Gu JW, 1998, HYPERTENSION, V31, P1083, DOI 10.1161/01.HYP.31.5.1083
   Gudbjornsdottir S, 1996, J HYPERTENS, V14, P91
   Hall JE, 2004, ADV RENAL REPLACE TH, V11, P41, DOI 10.1053/j.arrt.2003.10.007
   Hall JE, 1997, AM J HYPERTENS, V10, pS49, DOI 10.1016/S0895-7061(97)00075-7
   Hall JE, 2000, BRAZ J MED BIOL RES, V33, P605, DOI 10.1590/S0100-879X2000000600001
   HALL JE, 1995, HYPERTENSION, V25, P994, DOI 10.1161/01.HYP.25.5.994
   Hall ME, 2014, INT J NEPHROL RENOV, V7, P75, DOI 10.2147/IJNRD.S39739
   Hansen TK, 2002, CLIN ENDOCRINOL, V56, P203, DOI 10.1046/j.0300-0664.2001.01456.x
   He JA, 2000, HYPERTENSION, V35, P544, DOI 10.1161/01.HYP.35.2.544
   Henegar JR, 2001, J AM SOC NEPHROL, V12, P1211, DOI 10.1681/ASN.V1261211
   HIRSCH J, 1991, AM J PHYSIOL, V261, pR1418, DOI 10.1152/ajpregu.1991.261.6.R1418
   Hsu CY, 2006, ANN INTERN MED, V144, P21, DOI 10.7326/0003-4819-144-1-200601030-00006
   Jacob S, 1998, AM J HYPERTENS, V11, P1258, DOI 10.1016/S0895-7061(98)00141-1
   Jansen PM, 2010, CURR HYPERTENS REP, V12, P220, DOI 10.1007/s11906-010-0123-5
   Jensen MD, 2014, J AM COLL CARDIOL, V63, P2985, DOI 10.1016/j.jacc.2013.11.004
   Johansson ME, 2008, AM J PHYSIOL-REG I, V294, pR1240, DOI 10.1152/ajpregu.00493.2007
   JONES DW, 1994, J HYPERTENS, V12, P1433, DOI 10.1097/00004872-199412000-00018
   Jones DW, 1999, AM J HYPERTENS, V12, P1175, DOI 10.1016/S0895-7061(99)00123-5
   Jordan J, 2007, HYPERTENSION, V49, P1047, DOI 10.1161/HYPERTENSIONAHA.106.084301
   Jordan J, 2012, J HYPERTENS, V30, P1047, DOI 10.1097/HJH.0b013e3283537347
   Kaiser T, 2006, J HYPERTENS, V24, P1397, DOI 10.1097/01.hjh.0000234121.48272.67
   Kalupahana NS, 2012, MOL ASPECTS MED, V33, P26, DOI 10.1016/j.mam.2011.10.011
   KANNEL WB, 1967, ANN INTERN MED, V67, P48, DOI 10.7326/0003-4819-67-1-48
   Kellendonk C, 2002, ENDOCRINOLOGY, V143, P2333, DOI 10.1210/en.143.6.2333
   Kidambi S, 2007, HYPERTENSION, V49, P704, DOI 10.1161/01.HYP.0000253258.36141.c7
   Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213
   Knudson JD, 2008, CURR HYPERTENS REP, V10, P434, DOI 10.1007/s11906-008-0082-2
   Korda M, 2008, AM J PHYSIOL-HEART C, V295, pH1514, DOI 10.1152/ajpheart.00479.2008
   Kos K, 2007, J CLIN ENDOCR METAB, V92, P1129, DOI 10.1210/jc.2006-1841
   Kotsis VT, 2006, OBESITY, V14, P1708, DOI 10.1038/oby.2006.196
   Kurukulasuriya LR, 2011, MED CLIN N AM, V95, P903, DOI 10.1016/j.mcna.2011.06.004
   Lambert E, 2007, HYPERTENSION, V50, P862, DOI 10.1161/HYPERTENSIONAHA.107.094649
   Lambert E, 2010, HYPERTENSION, V56, P351, DOI 10.1161/HYPERTENSIONAHA.110.155663
   LANDSBERG L, 1986, Q J MED, V61, P1081
   Landsberg L, 2013, OBESITY, V21, P8, DOI 10.1002/oby.20181
   LEVY Y, 1993, ANGIOLOGY, V44, P713, DOI 10.1177/000331979304400907
   Li J, 2009, J NUTR, V139, P447, DOI 10.3945/jn.108.097451
   Li R, 2010, EUR J PHARMACOL, V628, P140, DOI 10.1016/j.ejphar.2009.11.038
   Liao DP, 1999, HYPERTENSION, V34, P201, DOI 10.1161/01.HYP.34.2.201
   Lindsay RS, 2003, J CLIN ENDOCR METAB, V88, P2738, DOI 10.1210/jc.2002-030017
   Liu JK, 2006, J HYPERTENS, V24, P1391, DOI 10.1097/01.hjh.0000234120.71142.6c
   Ma Y, 2015, HYPERTENSION, V66, P843, DOI 10.1161/HYPERTENSIONAHA.115.05948
   Mancia G, 2006, J HYPERTENS, V24, P3, DOI 10.1097/01.hjh.0000194119.42722.21
   Mancia G, 2013, EUR HEART J, V34, P2159, DOI 10.1093/eurheartj/eht151
   Mark AL, 1999, J HYPERTENS, V17, P1949, DOI 10.1097/00004872-199917121-00026
   Massiéra F, 2001, FASEB J, V15, P2727, DOI 10.1096/fj.01-0457fje
   Masuzaki H, 2003, J CLIN INVEST, V112, P83, DOI [10.1172/JCI200317845, 10.1172/JCI17845]
   Matsuda M, 2002, J BIOL CHEM, V277, P37487, DOI 10.1074/jbc.M206083200
   Matsumura K, 2003, REGUL PEPTIDES, V114, P79, DOI 10.1016/S0167-0115(03)00116-2
   MESSERLI FH, 1981, ARCH INTERN MED, V141, P81, DOI 10.1001/archinte.141.1.81
   MESSERLI FH, 1983, ANN INTERN MED, V99, P757, DOI 10.7326/0003-4819-99-6-757
   MESSERLI FH, 1982, CONTRIB NEPHROL, V30, P116
   MESSERLI FH, 1982, CIRCULATION, V66, P55, DOI 10.1161/01.CIR.66.1.55
   MESSERLI FH, 1982, LANCET, V1, P1165
   MESSERLI FH, 1983, AM J MED, V74, P808, DOI 10.1016/0002-9343(83)91071-9
   Michailidou Z, 2007, J ENDOCRINOL, V194, P161, DOI 10.1677/JOE-07-0090
   Montagnani M, 2000, DIABETES OBES METAB, V2, P285, DOI 10.1046/j.1463-1326.2000.00092.x
   MUNTZEL MS, 1994, AM J PHYSIOL-REG I, V267, pR1350, DOI 10.1152/ajpregu.1994.267.5.R1350
   Myers MG, 2008, ANNU REV PHYSIOL, V70, P537, DOI 10.1146/annurev.physiol.70.113006.100707
   Neter JE, 2003, HYPERTENSION, V42, P878, DOI 10.1161/01.HYP.0000094221.86888.AE
   NIZET A, 1971, PFLUG ARCH EUR J PHY, V323, P11, DOI 10.1007/BF00586561
   Oberleithner H, 2007, P NATL ACAD SCI USA, V104, P16281, DOI 10.1073/pnas.0707791104
   Öner-Iyidogan Y, 2007, SCAND J CLIN LAB INV, V67, P568, DOI 10.1080/00365510701210186
   Ohshima K, 2012, HYPERTENSION, V59, P493, DOI 10.1161/HYPERTENSIONAHA.111.183178
   Ouedraogo R, 2007, J CLIN INVEST, V117, P1718, DOI 10.1172/JCI29623
   Ozata M, 1999, J CLIN ENDOCR METAB, V84, P3686, DOI 10.1210/jc.84.10.3686
   PAFFENBARGER RS, 1993, NEW ENGL J MED, V328, P538, DOI 10.1056/NEJM199302253280804
   Pepine CJ, 2003, JAMA-J AM MED ASSOC, V290, P2805, DOI 10.1001/jama.290.21.2805
   Phillips SA, 2010, CURR OPIN PHARMACOL, V10, P676, DOI 10.1016/j.coph.2010.08.002
   Pi-Sunyer F, 2006, JAMA-J AM MED ASSOC, V295, P761, DOI 10.1001/jama.295.7.761
   Pischon T, 2001, Obes Rev, V2, P275, DOI 10.1046/j.1467-789X.2001.00044.x
   Poirier P, 2006, CIRCULATION, V113, P898, DOI 10.1161/CIRCULATIONAHA.106.171016
   Pou KM, 2007, CIRCULATION, V116, P1234, DOI 10.1161/CIRCULATIONAHA.107.710509
   Rahmouni K, 2005, DIABETES, V54, P2012, DOI 10.2337/diabetes.54.7.2012
   REISIN E, 1983, ANN INTERN MED, V98, P315, DOI 10.7326/0003-4819-98-3-315
   REISIN E, 1982, J CHRON DIS, V35, P887, DOI 10.1016/0021-9681(82)90119-9
   Reisin E, 1997, HYPERTENSION, V30, P140, DOI 10.1161/01.HYP.30.1.140
   ROBLES RG, 1993, AM J HYPERTENS, V6, P1009, DOI 10.1093/ajh/6.12.1009
   ROCCHINI AP, 1989, NEW ENGL J MED, V321, P580, DOI 10.1056/NEJM198908313210905
   Rocha VZ, 2011, INT J INFLAMM, V2011, DOI 10.4061/2011/529061
   Ruano M, 2005, OBES SURG, V15, P670, DOI 10.1381/0960892053923734
   Rumantir MS, 1999, J HYPERTENS, V17, P1125, DOI 10.1097/00004872-199917080-00012
   Sandoo A, 2010, OPEN CARDIOVASC MED, V4, P302, DOI 10.2174/1874192401004010302
   Sanjuliani AF, 2006, INT J CLIN PRACT, V60, P621, DOI 10.1111/j.1368-5031.2006.00951.x
   Sanz-Rosa D, 2005, ANTIOXID REDOX SIGN, V7, P1294, DOI 10.1089/ars.2005.7.1294
   Scheen AJ, 2004, DRUGS, V64, P2537, DOI 10.2165/00003495-200464220-00004
   SCHERRER U, 1994, CIRCULATION, V89, P2634, DOI 10.1161/01.CIR.89.6.2634
   Scherrer U, 1996, NEW ENGL J MED, V335, P1240, DOI 10.1056/NEJM199610173351617
   Schmieder RE, 2009, J HYPERTENS, V27, P1493, DOI 10.1097/HJH.0b013e32832be593
   Schnabel R, 2008, HYPERTENSION, V51, P1651, DOI 10.1161/HYPERTENSIONAHA.107.105668
   Scholze J, 2007, CIRCULATION, V115, P1991, DOI 10.1161/CIRCULATIONAHA.106.625400
   Shaltout HA, 2012, HYPERTENSION, V59, P453, DOI 10.1161/HYPERTENSIONAHA.111.185876
   Shibao C, 2007, HYPERTENSION, V49, P27, DOI 10.1161/01.HYP.0000251679.87348.05
   Sjöström L, 2007, NEW ENGL J MED, V357, P741, DOI 10.1056/NEJMoa066254
   Sorof JM, 2004, PEDIATRICS, V113, P475, DOI 10.1542/peds.113.3.475
   Sprague AH, 2009, BIOCHEM PHARMACOL, V78, P539, DOI 10.1016/j.bcp.2009.04.029
   Stamler J, 1997, AM J CLIN NUTR, V65, P626, DOI 10.1093/ajcn/65.2.626S
   STAMLER R, 1978, JAMA-J AM MED ASSOC, V240, P1607, DOI 10.1001/jama.240.15.1607
   STEPNIAKOWSKI KT, 1995, HYPERTENSION, V25, P774, DOI 10.1161/01.HYP.25.4.774
   Stevens VJ, 2001, ANN INTERN MED, V134, P1, DOI 10.7326/0003-4819-134-1-200101020-00007
   Sugerman H, 1997, J INTERN MED, V241, P71, DOI 10.1046/j.1365-2796.1997.89104000.x
   Szasz T, 2013, VASC HEALTH RISK MAN, V9, P105, DOI 10.2147/VHRM.S33760
   Tanida M, 2007, EXP BIOL MED, V232, P390
   Timpson NJ, 2009, J BONE MINER RES, V24, P522, DOI 10.1359/JBMR.081109
   Tomiyama H, 2009, AM J HYPERTENS, V22, P630, DOI 10.1038/ajh.2009.49
   Torgerson JS, 2004, DIABETES CARE, V27, P155, DOI 10.2337/diacare.27.1.155
   Van Gaal LF, 2008, EUR HEART J, V29, P1761, DOI 10.1093/eurheartj/ehn076
   VANVLIET BN, 1995, AM J PHYSIOL-HEART C, V269, pH629, DOI 10.1152/ajpheart.1995.269.2.H629
   Vasan RS, 2001, LANCET, V358, P1682, DOI 10.1016/S0140-6736(01)06710-1
   Vaz M, 1997, CIRCULATION, V96, P3423
   Verma S, 2001, AM J HYPERTENS, V14, P429, DOI 10.1016/S0895-7061(00)01261-9
   Wang TJ, 2004, CIRCULATION, V109, P594, DOI 10.1161/01.CIR.0000112582.16683.EA
   Wang WM, 2014, J INT MED RES, V42, P1202, DOI 10.1177/0300060514543040
   Wang ZV, 2008, HYPERTENSION, V51, P8, DOI 10.1161/HYPERTENSIONAHA.107.099424
   Weiss R, 2004, NEW ENGL J MED, V350, P2362, DOI 10.1056/NEJMoa031049
   Weyer C, 2001, J CLIN ENDOCR METAB, V86, P1930, DOI 10.1210/jc.86.5.1930
   WHELTON PK, 1992, JAMA-J AM MED ASSOC, V267, P1213, DOI 10.1001/jama.1992.03480090061028
   Whelton PK, 1998, JAMA-J AM MED ASSOC, V279, P839, DOI 10.1001/jama.279.11.839
   Whelton SP, 2002, ANN INTERN MED, V136, P493, DOI 10.7326/0003-4819-136-7-200204020-00006
   Whitworth JA, 2001, CLIN EXP PHARMACOL P, V28, P993, DOI 10.1046/j.1440-1681.2001.03584.x
   Yang QH, 2012, PEDIATRICS, V130, P611, DOI 10.1542/peds.2011-3870
   Zhang SY, 2013, MOL MED REP, V7, P223, DOI 10.3892/mmr.2012.1154
   Zhong JX, 2014, DIABETES, V63, P1289, DOI 10.2337/db13-1094
NR 186
TC 35
Z9 42
U1 0
U2 8
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0025-7125
EI 1557-9859
J9 MED CLIN N AM
JI Med. Clin. N. Am.
PD JAN
PY 2017
VL 101
IS 1
BP 139
EP +
DI 10.1016/j.mcna.2016.08.008
PG 20
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EG3UQ
UT WOS:000390970600014
PM 27884225
DA 2025-06-11
ER

PT J
AU Benson, J
   DeVries, M
   McLaurin-Jiang, S
   Garner, CD
AF Benson, Jessie
   DeVries, Matthew
   McLaurin-Jiang, Skye
   Garner, Christine D.
TI Experiences accessing nutritious foods and perceptions of nutritional
   support needs among pregnant and post-partum mothers with low income in
   the United States
SO MATERNAL AND CHILD NUTRITION
LA English
DT Article
DE food assistance; maternal nutrition; meal programme; post-partum period;
   pregnancy; qualitative; social determinants
ID WEIGHT RETENTION; INSECURITY; KNOWLEDGE
AB Access to nutritious foods, a social determinant of health, contributes to disparities in maternal and infant health outcomes such as mental health, breastfeeding intensity and cardiometabolic risk. This study explored perceived nutrition access and intake among pregnant or post-partum women eligible for Medicaid. Qualitative, semistructured interviews were conducted with 18 women who were either currently pregnant (n = 4) or up to 12 months post-partum (n = 14) in 2021-2022. Mothers spoke English (n = 11) or Spanish (n = 7) and lived in the Texas Panhandle. Interviews were audio-recorded, transcribed, translated (Spanish to English) and verified. Two or more researchers coded each interview until consensus was reached using thematic analysis with ATLAS.ti software. The study revealed five drivers for nutrition access. (1) Social factors influenced nutrition; those with less support expressed limited ability to eat healthfully. (2) The Women, Infants and Children program was perceived as a helpful resource for some, while others faced challenges obtaining it. (3) Stress was bidirectionally related to unhealthy food choices, with food sometimes used as a coping mechanism. (4) Mothers prioritized their babies and others and had limited ability and time to prepare healthy meals. (5) Most participants felt they received inadequate nutrition guidance from their healthcare providers. Participants provided positive responses to a proposed nutritious home-delivered meal intervention. Low-income women may experience nutritional challenges specific to this life stage. Interventions that reduce stress and burden of household tasks (e.g. cooking) and improve education and access to nutritious foods may improve mothers' ability to consume nutritious foods.
   Social support, stress, prioritization of others and lack of professional guidance influenced access to and consumption of nutritious foods during and after pregnancy. image
   Pregnant and post-partum women desire to eat nutritious foods for their own health and that of their infants. More support is needed for women in the post-partum period as prioritization of others and the stressful transition of caring for a newborn hinder women from maintaining healthy eating habits. Pregnant and post-partum women want focused nutritional guidance from their healthcare providers. A home-delivered, nutritious meal programme may be an acceptable intervention to help alleviate the nutritional barriers that are faced by pregnant and post-partum women.
C1 [Benson, Jessie; DeVries, Matthew] Texas Tech Univ Hlth Sci Ctr, Sch Med, Amarillo, TX 79106 USA.
   [DeVries, Matthew] Phoenix Childrens Hosp, Phoenix, AZ USA.
   [McLaurin-Jiang, Skye] Texas Tech Univ Hlth Sci Ctr, Dept Pediat, Amarillo, TX USA.
   [Garner, Christine D.] Texas Tech Univ Hlth Sci Ctr, InfantRisk Ctr, Amarillo, TX USA.
   [Garner, Christine D.] Texas Tech Univ Hlth Sci Ctr, Dept Obstet & Gynecol, Amarillo, TX USA.
C3 Texas Tech University System; Texas Tech University Health Sciences
   Center Amarillo; Texas Tech University Health Sciences Center Lubbock;
   Phoenix Children's Hospital; Texas Tech University System; Texas Tech
   University Health Sciences Center Amarillo; Texas Tech University Health
   Sciences Center Lubbock; Texas Tech University System; Texas Tech
   University Health Sciences Center Amarillo; Texas Tech University Health
   Sciences Center Lubbock; Texas Tech University System; Texas Tech
   University Health Sciences Center Amarillo; Texas Tech University Health
   Sciences Center Lubbock
RP Benson, J (corresponding author), Texas Tech Univ Hlth Sci Ctr, Sch Med, Amarillo, TX 79106 USA.
EM jessiebenson720@gmail.com
OI Benson, Jessie/0000-0002-5103-3959; McLaurin-Jiang,
   Skyler/0000-0001-7160-5128
FU Laura W. Bush Institute for Women's Health
FX The authors thank Ashley Allcorn, MA, LCSW, and Ilean McCarthy, LCSW,
   for assistance with the development of the interview guide and conduct
   of the interviews and focus groups; Teresa Baker, MD, and Maury Roman,
   MBA for assistance with participant recruitment; and Brenda Garcia, MS,
   RD, manager of health and wellness for United Supermarkets stores, for
   assistance with design and selection of prepared nutritious meals. This
   study was supported by funding from the Laura W. Bush Institute for
   Women's Health.
CR [Anonymous], 2018, Obstet Gynecol, V131, pe115, DOI 10.1097/AOG.0000000000002589
   [Anonymous], 2022, QuickFacts
   Arrish J, 2016, WOMEN BIRTH, V29, P455, DOI 10.1016/j.wombi.2016.03.001
   Asim M, 2022, PUBLIC HEALTH NUTR, V25, P760, DOI 10.1017/S1368980021001737
   Belak L, 2022, BMC NUTR, V8, DOI 10.1186/s40795-022-00602-y
   Berkowitz SA, 2020, BMC ENDOCR DISORD, V20, DOI 10.1186/s12902-020-0491-z
   Berkowitz SA, 2019, J GEN INTERN MED, V34, P396, DOI 10.1007/s11606-018-4716-z
   Braun V., 2006, QUAL RES PSYCHOL, V3, P77, DOI [DOI 10.1191/1478088706QP063OA, DOI 10.1080/14780887.2020.1769238]
   CAAN B, 1987, AM J CLIN NUTR, V45, P29, DOI 10.1093/ajcn/45.1.29
   Caulfield L. E., 2022, AGENCY HEALTHCARE RE, DOI [10.23970/ahrqepccer253, DOI 10.23970/AHRQEPCCER253]
   Cornish DL, 2018, J PERINAT EDUC, V27, P233, DOI 10.1891/1058-1243.27.4.233
   Davis RA, 2022, J COMMUN HEALTH, V47, P990, DOI 10.1007/s10900-022-01131-2
   Dror DK, 2018, ADV NUTR, V9, p278S, DOI 10.1093/advances/nmy022
   Emmanuel E, 2008, J ADV NURS, V64, P18, DOI 10.1111/j.1365-2648.2008.04757.x
   Endres LK, 2015, OBSTET GYNECOL, V125, P144, DOI 10.1097/AOG.0000000000000565
   Farrar Diane, 2013, Pract Midwife, V16, P16
   Gill Sara L, 2004, J Perinat Educ, V13, P39, DOI 10.1624/105812404X1761
   Grenier LN, 2021, MATERN CHILD NUTR, V17, DOI 10.1111/mcn.13068
   Gross RS, 2019, PEDIATRICS, V143, DOI 10.1542/peds.2018-4113
   Gross SM, 2023, ACAD PEDIATR, V23, P244, DOI 10.1016/j.acap.2022.10.008
   Huang TS, 2024, J NUTR, V154, P777, DOI 10.1016/j.tjnut.2023.12.029
   Jardí C, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102447
   Kelly C, 2023, PUBLIC HEALTH NURS, V40, P497, DOI 10.1111/phn.13184
   Kovell LC, 2022, CARDIOVASC DIGIT HLT, V3, pS1, DOI 10.1016/j.cvdhj.2022.10.001
   Langley-Evans SC, 2022, J HUM NUTR DIET, V35, P250, DOI 10.1111/jhn.12999
   Laraia BA, 2010, J AM DIET ASSOC, V110, P692, DOI 10.1016/j.jada.2010.02.014
   Lee A, 2018, WOMEN BIRTH, V31, P269, DOI 10.1016/j.wombi.2017.10.010
   Li CL, 2021, J INT MED RES, V49, DOI 10.1177/03000605211033193
   Lincoln Y. S., 1985, NATURALISTIC INQUIRY
   McMahon SA, 2018, BMJ GLOB HEALTH, V3, DOI 10.1136/bmjgh-2018-000837
   McNamara JA, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19105849
   Meulenbroeks D, 2021, NUTRIENTS, V13, DOI 10.3390/nu13072394
   Millan KD, 2022, NUTR HEALTH-UK, V28, P563, DOI 10.1177/02601060211038842
   Murray-Davis B, 2020, BMC PREGNANCY CHILDB, V20, DOI 10.1186/s12884-020-2791-8
   Murray-Davis B, 2019, BMC PREGNANCY CHILDB, V19, DOI 10.1186/s12884-019-2508-z
   Nuss H, 2007, J AM DIET ASSOC, V107, P1801, DOI 10.1016/j.jada.2007.07.010
   O'Brien BC, 2014, ACAD MED, V89, P1245, DOI 10.1097/ACM.0000000000000388
   Opie RS, 2020, MATERN CHILD HLTH J, V24, P966, DOI 10.1007/s10995-020-02949-9
   Sámano R, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020362
   Tapper EB, 2020, GASTROENTEROL REP, V8, P453, DOI 10.1093/gastro/goaa059
   Tarasuk V, 2020, J NUTR, V150, P3033, DOI 10.1093/jn/nxaa240
   US Department of Agriculture Economic Research Service, 2021, Key statistics & graphics
   Venkatesh KK, 2023, J NUTR, V153, P2432, DOI 10.1016/j.tjnut.2023.06.032
   Weinfield NS, 2020, J ACAD NUTR DIET, V120, P963, DOI 10.1016/j.jand.2019.12.012
NR 44
TC 2
Z9 2
U1 2
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1740-8695
EI 1740-8709
J9 MATERN CHILD NUTR
JI Matern. Child Nutr.
PD OCT
PY 2024
VL 20
IS 4
DI 10.1111/mcn.13660
EA MAY 2024
PG 11
WC Nutrition & Dietetics; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Pediatrics
GA M7F3B
UT WOS:001234293200001
PM 38812121
OA Green Published
DA 2025-06-11
ER

PT J
AU Sieminska, L
   Sieminska, K
   Ditffeld, A
   Kotecka-Blicharz, A
AF Sieminska, Lucyna
   Sieminska, Katarzyna
   Ditffeld, Anna
   Kotecka-Blicharz, Agnieszka
TI Fibroblast growth factor 21 in patients with mild autonomic cortisol
   secretion and non-functioning adrenal incidentalomas
SO ENDOKRYNOLOGIA POLSKA
LA English
DT Article
DE FGF21; adrenal incidentaloma; mild autonomic cortisol secretion; adrenal
   adenoma size; cardiometabolic index; lipid accumulation product; obesity
ID METABOLIC SYNDROME; CELL-PROLIFERATION; INSULIN-RESISTANCE; FGF21;
   EXPRESSION; GLUCOSE; OBESITY; LIVER
AB Introduction: Epidemiological studies have reported a link between adrenocortical adenomas (ACA), obesity, and cardiometabolic risk. Fibroblast growth factor 21 (FGF21) is a stress-induced protein synthesised predominantly in the liver, which regulates metabolism. The aim of the current study was to evaluate the concentration of FGF21 in patients with ACA and its relationship with hypothalamic-pituitary-adrenal function, obesity, markers of cardiometabolic health, and adenoma size. Material and methods: A total of 197 patients with ACA were included in the analysis, 82 diagnosed with mild autonomous cortisol secretion (MACS) and 115 with non-functioning adrenal adenoma incidentaloma (NFAI). MACS was defined as serum cortisol concentration post 1 mg dexamethasone test (DST) >= 1.8 mu g/dL. In each patient weight, height, and waist circumference were measured, and body mass index (BMI) was calculated. Serum concentrations of FGF21, cortisol, dehydroepiandrosterone sulphate, adrenocorticotropic hormone (ACTH), total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides, glucose, and insulin were measured. The cortisol-to-ACTH ratio, homeostatic model assessment for insulin resistance index (HOMA-IR), lipid accumulation product (LAP), and cardiometabolic index (CMI) were calculated. Adrenal tumour size was evaluated from imaging procedures. Results: Serum FGF21 concentrations were significantly higher in patients with MACS than in NFAI, which was independent of BMI. There were no differences between MACS and NFAI groups regarding HOMA-IR, LAP, and CMI. We observed a positive correlation between serum FGF21 concentration and cortisol level after DST, as well as the cortisol-to-ACTH ratio. FGF21 was negatively correlated with dehydroepiandrosterone sulphate (DHEAS). There were no significant correlations between serum FGF21 concentration and BMI, waist circumference, and HOMA-IR, but serum FGF21 levels were positively correlated with TG, LAP, and CMI. Positive relationships between adenoma size and serum FGF21 concentration were found. Conclusions: Higher levels of FGF21 in adrenal tumours with MACS when compared with NFAI represent another pathophysiological link related to chronic glucocorticoid excess. (Endokrynol Pol 2024; 75 (6): 672-683)
C1 [Sieminska, Lucyna] Med Univ Silesia, Fac Med Sci Zabrze, Dept Pathophysiol & Endocrinol, Pathophysiol Div, Katowice, Poland.
   [Sieminska, Katarzyna] Med Univ Silesia, Dept Pathophysiol & Endocrinol, Pathophysiol Div, Sci Students Assoc,Fac Med Sci Zabrze, Katowice, Poland.
   [Ditffeld, Anna] Cty Hosp, Endocrinol Ambulatory, Piekary Slaskie, Poland.
   [Kotecka-Blicharz, Agnieszka] Maria Sklodowska Curie Natl Res Inst Oncology, Dept Nucl Med & Endocrine Oncol, Gliwice, Silesia, Poland.
C3 Medical University of Silesia; Medical University of Silesia
RP Sieminska, L (corresponding author), Med Univ Silesia, Fac Med Sci Zabrze, Dept Pathophysiol & Endocrinol, Pathophysiol Div, Katowice, Poland.
EM LSieminska@sum.edu.pl
OI Kotecka-Blicharz, Agnieszka/0000-0002-8086-7346
FU Medical University of Silesia [PCN-1-140-N-0/K, PCN-1-081/K/1/K]
FX Funding This work was funded by the Medical University of Silesia, grant
   Nos. PCN-1-140-N-0/K and PCN-1-081/K/1/K
CR Al-Aqil FA, 2018, BBA-MOL BASIS DIS, V1864, P2927, DOI 10.1016/j.bbadis.2018.06.003
   Altieri B, 2016, INT J CANCER, V138, P2785, DOI 10.1002/ijc.29950
   Araujo-Castro M, 2021, J CLIN MED, V10, DOI 10.3390/jcm10235509
   Arruda M, 2017, J HUM HYPERTENS, V32, P3, DOI 10.1038/s41371-017-0011-4
   Bancos I, 2021, J CLIN ENDOCR METAB, V106, P3331, DOI 10.1210/clinem/dgab512
   Bookout AL, 2013, NAT MED, V19, P1147, DOI 10.1038/nm.3249
   Boscaro M, 2012, ANN NY ACAD SCI, V1264, P87, DOI 10.1111/j.1749-6632.2012.06597.x
   Boutari Chrysoula, 2022, Metabolism, V133, P155217, DOI 10.1016/j.metabol.2022.155217
   Crudele L, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1159127
   Cymbaluk-Ploska A, 2020, DIAGNOSTICS, V10, DOI 10.3390/diagnostics10060414
   Cyranska-Chyrek E, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16101872
   Díaz-Delfín J, 2012, ENDOCRINOLOGY, V153, P4238, DOI 10.1210/en.2012-1193
   Dille M, 2022, BBA-MOL BASIS DIS, V1868, DOI 10.1016/j.bbadis.2021.166286
   Durovcová V, 2010, PHYSIOL RES, V59, P415, DOI 10.33549/physiolres.931801
   Elhassan YS, 2019, ANN INTERN MED, V171, P107, DOI 10.7326/M18-3630
   Fassnacht M, 2023, EUR J ENDOCRINOL, V189, pG1, DOI 10.1093/ejendo/lvad066
   Fisher FM, 2010, DIABETES, V59, P2781, DOI 10.2337/db10-0193
   Florea A, 2021, J GASTROINTEST CANC, V52, P940, DOI 10.1007/s12029-020-00515-8
   FREEDMAN MR, 1986, AM J PHYSIOL, V250, pR595, DOI 10.1152/ajpregu.1986.250.4.R595
   GOSPODAROWICZ D, 1977, ENDOCRINOLOGY, V100, P1080
   Hao L, 2016, J NUTR, V146, P184, DOI 10.3945/jn.115.216572
   Hondares E, 2011, J BIOL CHEM, V286, P12983, DOI 10.1074/jbc.M110.215889
   HORNSBY PJ, 1977, J CLIN INVEST, V60, P342, DOI 10.1172/JCI108782
   Iwamoto Y, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-22676-1
   Jimeno B, 2023, ELIFE, V12, DOI 10.7554/eLife.88205
   Kang YE, 2019, CANCERS, V11, DOI 10.3390/cancers11081154
   Karatas S, 2023, ARCH ENDOCRIN METAB, V67, P323, DOI 10.20945/2359-3997000000547
   Kim H, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24087284
   Kiszczak-Bochynska E, 2014, FAM MED PRIM CARE RE, V16, P242
   Kuckuck S, 2023, OBES REV, V24, DOI 10.1111/obr.13539
   Kurylowicz A, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21176241
   Larson KR, 2024, ENDOCRINOLOGY, V165, DOI 10.1210/endocr/bqae004
   Lee SA, 2012, DIABETES METAB J, V36, P29, DOI 10.4093/dmj.2012.36.1.29
   Lerario AM, 2017, FRONT ENDOCRINOL, V8, DOI 10.3389/fendo.2017.00052
   Li S, 2024, GENES DIS, V11, DOI 10.1016/j.gendis.2023.06.033
   Liang QN, 2014, DIABETES, V63, P4064, DOI 10.2337/db14-0541
   Matuszek B, 2010, ENDOKRYNOL POL, V61, P50
   Midorikawa S, 2001, CLIN ENDOCRINOL, V54, P797, DOI 10.1046/j.1365-2265.2001.01274.x
   Morelli V, 2014, J CLIN ENDOCR METAB, V99, P827, DOI 10.1210/jc.2013-3527
   Morrice N, 2017, SCI REP-UK, V7, DOI 10.1038/srep43782
   Muscogiuri G, 2011, CLIN ENDOCRINOL, V74, P300, DOI 10.1111/j.1365-2265.2010.03928.x
   Ors D, 2016, ENDOKRYNOL POL, V67, P260, DOI 10.5603/EP.a2016.0016
   Pan XB, 2018, CELL METAB, V27, P1323, DOI 10.1016/j.cmet.2018.04.002
   Patel R, 2015, MOL ENDOCRINOL, V29, P213, DOI 10.1210/me.2014-1259
   Patrova J, 2017, ENDOCRINE, V58, P267, DOI 10.1007/s12020-017-1400-8
   Pelsma ICM, 2023, EUR J ENDOCRINOL, V189, pS88, DOI 10.1093/ejendo/lvad134
   Peppa M, 2010, J INTERN MED, V268, P555, DOI 10.1111/j.1365-2796.2010.02291.x
   Podbregar A, 2020, BMC ENDOCR DISORD, V20, DOI 10.1186/s12902-020-00599-0
   Prete A, 2024, NAT REV ENDOCRINOL, V20, P460, DOI 10.1038/s41574-024-00984-y
   Reimondo G, 2020, J CLIN ENDOCR METAB, V105, DOI 10.1210/clinem/dgz284
   Reincke M, 1996, ENDOCR RES, V22, P757, DOI 10.1080/07435809609043773
   Sbiera I, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.795116
   Solon-Biet SM, 2023, CELL REP, V42, DOI 10.1016/j.celrep.2023.113536
   Sydney GI, 2019, MATURITAS, V121, P1, DOI 10.1016/j.maturitas.2018.12.002
   Szczepanska E, 2022, HORM METAB RES, V54, P203, DOI 10.1055/a-1778-4159
   Szychlinska M, 2023, ENDOKRYNOL POL, V74, P623, DOI 10.5603/ep.95139
   Tamburello M, 2022, ENDOCRINE, V77, P411, DOI 10.1007/s12020-022-03074-z
   Tyynismaa H, 2011, J CLIN ENDOCR METAB, V96, pE351, DOI 10.1210/jc.2010-1326
   Ueland GÅ, 2023, EUR J ENDOCRINOL, V189, P78, DOI 10.1093/ejendo/lvad076
   Vernia S, 2014, CELL METAB, V20, P512, DOI 10.1016/j.cmet.2014.06.010
   Vispute SG, 2017, TOXICOLOGY, V378, P95, DOI 10.1016/j.tox.2017.01.009
   Woo YC, 2017, CLIN ENDOCRINOL, V86, P37, DOI 10.1111/cen.13229
   World Health Organization, 2023, World health statistics 2023: Monitoring health for the SDGs, Sustainable development goals, DOI DOI 10.1080/09638288.2019.1641851
   Xu JY, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms241914922
   Yang M, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1220426
   Yu HY, 2011, CLIN CHEM, V57, P691, DOI 10.1373/clinchem.2010.155184
   Zhang X, 2008, DIABETES, V57, P1246, DOI 10.2337/db07-1476
NR 67
TC 0
Z9 0
U1 0
U2 0
PU VIA MEDICA
PI GDANSK
PA UL SWIETOKRZYSKA 73, 80-180 GDANSK, POLAND
SN 0423-104X
J9 ENDOKRYNOL POL
JI Endokrynol. Pol.
PY 2024
VL 75
IS 6
BP 672
EP 683
DI 10.5603/ep.102598
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA Q7N9Z
UT WOS:001386511500001
PM 40091329
OA gold
DA 2025-06-11
ER

PT J
AU Dixon, JB
   Hayden, MJ
   Lambert, GW
   Dawood, T
   Anderson, ML
   Dixon, ME
   O'Brien, PE
AF Dixon, John B.
   Hayden, Melissa J.
   Lambert, Gavin W.
   Dawood, Tye
   Anderson, Margaret L.
   Dixon, Maureen E.
   O'Brien, Paul E.
TI Raised CRP levels in obese patients: Symptoms of depression have an
   independent positive association
SO OBESITY
LA English
DT Article
ID C-REACTIVE PROTEIN; ACUTE MYOCARDIAL-INFARCTION; PSYCHOSOCIAL
   RISK-FACTORS; WEIGHT-LOSS; SYSTEMIC INFLAMMATION; CARDIOVASCULAR RISK;
   MAJOR DEPRESSION; HEART-DISEASE; MARKERS; INTERLEUKIN-6
AB Background: Depression and obesity, the two common ailments of modern society, are associated with increased risk of coronary artery disease and raised C-reactive protein (CRP) levels. Are the effects of depression and obesity related or do they influence CRP levels independently?
   Objective: In 493 consecutive patients presenting for obesity surgery, we explored the relationship between symptoms of depression and raised CRP levels after controlling for confounding factors.
   Methods and Procedures: Depression was measured using the Beck Depression Inventory (BDI). Confounding variables were age, gender, BMI, waist and hip measures, smoking and alcohol habits, medications, biochemical measures of the metabolic syndrome, and indirect measures of insulin resistance. General linear regression sought variables independently associated with CRP levels.
   Results: These patients had a BMI range from 31 to 91 kg/m(2), participants age ranged from 14 to 71 years, and 76% were women. The median CRP concentration was 7.7 mg/l (interquartile range: 3.9-14), 40% had an abnormally raised concentration (>10 mg/l). The mean BDI score was 17.0 +/- 9.0, indicating symptoms of moderate depression. We found five independent factors associated with raised CRP levels. In order of strength of association, these were: higher BMI (beta = 0.36, P < 0.001), female gender (beta = -0.19, P < 0.001), estrogen therapy (beta = 0.18, P < 0.001), higher BDI score (beta = 0.11, P = 0.01), and insulin resistance index (beta = 0.11, P = 0.01), and with a combined R-2 = 0.24, (P < 0.001).
   Discussion: In obese patients, symptoms of depression were associated with raised CRP levels after controlling for confounding variables. Obese women on estrogen therapy are at risk of high CRP levels.
C1 [Dixon, John B.; Hayden, Melissa J.; Anderson, Margaret L.; Dixon, Maureen E.; O'Brien, Paul E.] Monash Univ, Alfred Hosp, Ctr Obes Res & Educ, Melbourne, Vic 3181, Australia.
   [Dixon, John B.; Lambert, Gavin W.; Dawood, Tye] Alfred Hosp, Baker Heart Res Inst, Melbourne, Vic, Australia.
C3 Monash University; Florey Institute of Neuroscience & Mental Health;
   Howard Florey Institute Affiliates; Florey Institute of Neuroscience &
   Mental Health; Howard Florey Institute Affiliates; Baker Heart and
   Diabetes Institute
RP Dixon, JB (corresponding author), Monash Univ, Alfred Hosp, Ctr Obes Res & Educ, Melbourne, Vic 3181, Australia.
EM john.dixon@med.monash.edu.au
RI Dixon, John/A-5318-2011; Lambert, Gavin/E-7384-2010; Dawood,
   Tye/A-8826-2011
OI Hayden, Melissa/0000-0002-4837-5894; Dixon, John/0000-0001-6399-7010;
   Lambert, Gavin/0000-0003-0315-645X
CR Alesci S, 2005, J CLIN ENDOCR METAB, V90, P2522, DOI 10.1210/jc.2004-1667
   Barefoot JC, 1996, CIRCULATION, V93, P1976, DOI 10.1161/01.CIR.93.11.1976
   Beck A.T., 1979, COGNITIVE THERAPY DE
   Beck Aaron T., 1997, Behaviour Research and Therapy, V35, P785, DOI 10.1016/S0005-7967(97)00025-9
   Blake GJ, 2002, J INTERN MED, V252, P283, DOI 10.1046/j.1365-2796.2002.01019.x
   Bunker SJ, 2003, MED J AUSTRALIA, V178, P272, DOI 10.5694/j.1326-5377.2003.tb05193.x
   Dawood T, 2007, HYPERTENS RES, V30, P285, DOI 10.1291/hypres.30.285
   Dixon JB, 2003, ARCH INTERN MED, V163, P2058, DOI 10.1001/archinte.163.17.2058
   Dixon JB, 2002, AM J SURG, V184, p51S, DOI 10.1016/S0002-9610(02)01181-9
   Elovainio M, 2006, PSYCHOL MED, V36, P797, DOI 10.1017/S0033291706007574
   Ferketich AK, 2000, ARCH INTERN MED, V160, P1261, DOI 10.1001/archinte.160.9.1261
   Fontana L, 2007, DIABETES, V56, P1010, DOI 10.2337/db06-1656
   Ford DE, 2004, ARCH INTERN MED, V164, P1010, DOI 10.1001/archinte.164.9.1010
   Guilleminault C, 2004, SLEEP, V27, P1507, DOI 10.1093/sleep/27.8.1507
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   Kopp HP, 2005, INT J OBESITY, V29, P766, DOI 10.1038/sj.ijo.0802983
   Ladwig KH, 2003, BRAIN BEHAV IMMUN, V17, P268, DOI 10.1016/S0889-1591(03)00056-4
   Liukkonen T, 2006, BIOL PSYCHIAT, V60, P825, DOI 10.1016/j.biopsych.2006.02.016
   Lustman PJ, 1997, PSYCHOSOM MED, V59, P24, DOI 10.1097/00006842-199701000-00004
   MAES M, 1995, J AFFECT DISORDERS, V34, P301, DOI 10.1016/0165-0327(95)00028-L
   Martinsen EW, 1995, ACTA PSYCHIAT SCAND, V92, P460, DOI 10.1111/j.1600-0447.1995.tb09613.x
   Pearson TA, 2003, CIRCULATION, V107, P499, DOI 10.1161/01.CIR.0000052939.59093.45
   Pontiroli AE, 2002, J CLIN ENDOCR METAB, V87, P3555, DOI 10.1210/jc.87.8.3555
   Rosengren A, 2004, LANCET, V364, P953, DOI 10.1016/S0140-6736(04)17019-0
   ROTHSCHILD M, 1989, INT J OBESITY, V13, P479
   Straznicky NE, 2005, J CLIN ENDOCR METAB, V90, P5998, DOI 10.1210/jc.2005-0961
   Tchernof A, 2002, CIRCULATION, V105, P564, DOI 10.1161/hc0502.103331
   Tracey KJ, 2002, NATURE, V420, P853, DOI 10.1038/nature01321
   Visser M, 1999, JAMA-J AM MED ASSOC, V282, P2131, DOI 10.1001/jama.282.22.2131
   von Känel R, 2007, J PSYCHIATR RES, V41, P744, DOI 10.1016/j.jpsychires.2006.06.009
   Wong ML, 2000, P NATL ACAD SCI USA, V97, P8681, DOI 10.1073/pnas.150098097
NR 31
TC 34
Z9 40
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD SEP
PY 2008
VL 16
IS 9
BP 2010
EP 2015
DI 10.1038/oby.2008.271
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 345KP
UT WOS:000258996000005
PM 18497736
OA Bronze
DA 2025-06-11
ER

PT J
AU Karimzadeh, L
   Behrouz, V
   Sohrab, G
   Razavion, T
   Haji-Maghsoudi, S
AF Karimzadeh, Laleh
   Behrouz, Vahideh
   Sohrab, Golbon
   Razavion, Taraneh
   Haji-Maghsoudi, Saiedeh
TI The association between dietary nitrate, nitrite and total antioxidant
   capacity with cardiometabolic risk factors: a cross-sectional study
   among patients with type 2 diabetes
SO INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
LA English
DT Article
DE Nitrate; nitrite; DTAC; diabetes; glycemic indices; lipid profile
ID BLOOD-PRESSURE; INORGANIC NITRATE; CARDIOVASCULAR HEALTH; ENDOTHELIAL
   FUNCTION; INSULIN-RESISTANCE; METABOLIC SYNDROME; GLUCOSE-TOLERANCE;
   OXIDATIVE STRESS; SODIUM-NITRITE; LIPID PROFILE
AB Diabetes is a common, chronic, and complex disorder that leads to several disabilities and serious complications. Certain nutrients can be effective in the management of diabetes mellitus. In the present study, we aimed to investigate the effects of dietary nitrate, nitrite, dietary total antioxidant capacity (DTAC), and nitric oxide (NO) index on some cardiometabolic parameters in patients with diabetes. This cross-sectional study was conducted on 100 participants with type 2 diabetes. A validated, semi-quantitative, food frequency questionnaire was collected to evaluate dietary intakes. Anthropometric parameters, blood pressure, and biochemical parameters, including glycemic indices, lipid profile, high-sensitive C-reactive protein (hs-CRP), and serum NO were measured using standard methods. Higher intakes of nitrate and nitrite in our study were primarily attributed to drinking water, vegetables, grains (for nitrate), dairy products, and legumes (for nitrite) rather than higher meat intakes. After adjustment for total energy, MET, BMI, and age, higher intake of nitrate was related to lower HbA1C (p = 0.001) and hs-CRP (p = 0.0.23), and greater HDL-C (p < 0.001) and serum NO (p = 0.008). Moreover, a greater nitrite intake was associated with lower DBP (p = 0.017), HbA1C (p = 0.040), FPG (p = 0.011), and higher serum NO values (p = 0.001). Higher amounts of DTAC and NO index were also related to greater DBP (p < 0.001, and p = 0.004, respectively) and lower hs-CRP (p = 0.004, and p = 0.009, respectively). High intakes of dietary nitrate and nitrite, in the context of high DTAC, are significantly associated with the improvement of some cardiometabolic parameters in patients with diabetes. HIGHLIGHTS center dot A higher intake of nitrite is related to improving glycemic indices. center dot A higher intake of nitrate is related to increasing HDL-C and decreasing hs-CRP. center dot A higher intake of nitrate and nitrite, with a high DTAC index, is related to reduced cardiometabolic parameters.
C1 [Karimzadeh, Laleh; Sohrab, Golbon] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr & Food Technol, Dept Clin Nutr & Dietet, Tehran, Iran.
   [Behrouz, Vahideh] Kerman Univ Med Sci, Fac Publ Hlth, Dept Nutr, Kerman, Iran.
   [Razavion, Taraneh] Univ Tehran Med Sci, Dept Med Parasitol & Mycol Publ Hlth, Tehran, Iran.
   [Haji-Maghsoudi, Saiedeh] Kerman Univ Med Sci, Inst Futures Studies Hlth, Modeling Hlth Res Ctr, Kerman, Iran.
C3 Shahid Beheshti University Medical Sciences; Kerman University of
   Medical Sciences; Tehran University of Medical Sciences; Kerman
   University of Medical Sciences
RP Behrouz, V (corresponding author), Kerman Univ Med Sci, Fac Publ Hlth, Dept Nutr, Kerman, Iran.; Sohrab, G (corresponding author), Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Dept Clin Nutr & Dietet, Tehran, Iran.
EM golbonsohrab@yahoo.com
RI behrouz, vahideh/AAL-5105-2020; Sohrab, Golbon/AHE-4922-2022
FU Shahid Beheshti University of Medical Sciences [1401-0.23]
FX This study is supported by Shahid Beheshti University of Medical
   Sciences (grant number: 1401-0.23).
CR Amaral JH, 2015, REDOX BIOL, V5, P340, DOI 10.1016/j.redox.2015.06.009
   [Anonymous], 2018, DIABETES CARE, V41, pS1, DOI [10.2337/dc18-Sint01, 10.2337/dc18-SINT01]
   [Anonymous], 2005, Guidelines for Data Processing and Analysis of the International Physical Activity Questionnaire (IPAQ)
   Ashmore T, 2015, BMC BIOL, V13, DOI 10.1186/s12915-015-0221-6
   Ashor AW, 2017, J HYPERTENS, V35, P1353, DOI 10.1097/HJH.0000000000001305
   Azar M, 1980, Food composition table of Iran: National Nutrition and Food Research Institute
   Bahadoran Z, 2019, IRAN J PUBLIC HEALTH, V48, P162
   Bahadoran Z, 2018, NUTR METAB, V15, DOI 10.1186/s12986-018-0254-2
   Bahadoran Z, 2017, NITRIC OXIDE-BIOL CH, V62, P24, DOI 10.1016/j.niox.2016.11.005
   Bahadoran Z, 2016, J FOOD COMPOS ANAL, V51, P93, DOI 10.1016/j.jfca.2016.06.006
   Basaqr R, 2021, CLIN NUTR, V40, P1851, DOI 10.1016/j.clnu.2020.10.012
   Behrouz V, 2021, PHYTOTHER RES, V35, P4022, DOI 10.1002/ptr.7124
   Berens PD, 2011, NUTR HEALTH SER, P139, DOI 10.1007/978-1-60761-616-0_9
   Blekkenhorst LC, 2018, AM J CLIN NUTR, V107, P504, DOI 10.1093/ajcn/nqx046
   Bryan NS, 2007, P NATL ACAD SCI USA, V104, P19144, DOI 10.1073/pnas.0706579104
   Bryan NS, 2015, NUTR RES, V35, P643, DOI 10.1016/j.nutres.2015.06.001
   Carlström M, 2018, ACTA PHYSIOL, V224, DOI 10.1111/apha.13080
   Carlström M, 2010, P NATL ACAD SCI USA, V107, P17716, DOI 10.1073/pnas.1008872107
   Cermak NM, 2015, NUTR RES, V35, P674, DOI 10.1016/j.nutres.2015.05.017
   Charlton A, 2021, BIOLOGY-BASEL, V10, DOI 10.3390/biology10010018
   Daneshzad E, 2020, CLIN NUTR ESPEN, V37, P187, DOI 10.1016/j.clnesp.2020.03.002
   Faconti L, 2019, BRIT J CLIN PHARMACO, V85, P169, DOI 10.1111/bcp.13783
   Ghafarpour M., 1999, MANUAL HOUSEHOLD MEA
   Ghasemi A, 2017, NITRIC OXIDE-BIOL CH, V70, P9, DOI 10.1016/j.niox.2017.08.003
   Ghimire K, 2017, AM J PHYSIOL-CELL PH, V312, pC254, DOI 10.1152/ajpcell.00315.2016
   Gilchrist M., 2010, BMJ, V341
   Gilchrist M, 2014, NITRIC OXIDE-BIOL CH, V40, P67, DOI 10.1016/j.niox.2014.05.003
   Gilchrist M, 2013, FREE RADICAL BIO MED, V60, P89, DOI 10.1016/j.freeradbiomed.2013.01.024
   Govoni M, 2008, NITRIC OXIDE-BIOL CH, V19, P333, DOI 10.1016/j.niox.2008.08.003
   Haytowitz D.B., 2010, USDA database for the oxygen radical absorbance capacity (ORAC) of selected foods
   Hord NG, 2009, AM J CLIN NUTR, V90, P1, DOI 10.3945/ajcn.2008.27131
   Hunault CC, 2009, TOXICOL LETT, V190, P48, DOI 10.1016/j.toxlet.2009.06.865
   Jafari RS, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1215358
   Jalilvand A, 2020, DIABETES METAB SYND, V14, P849, DOI 10.1016/j.dsx.2020.04.003
   Jansson EÅ, 2008, NAT CHEM BIOL, V4, P411, DOI 10.1038/nchembio.92
   Jiang H, 2014, FREE RADICAL BIO MED, V67, P51, DOI 10.1016/j.freeradbiomed.2013.10.809
   Jiang WB, 2023, J CLIN ENDOCR METAB, V108, P1318, DOI 10.1210/clinem/dgac741
   Karimzadeh L, 2022, J FOOD SCI, V87, P5430, DOI 10.1111/1750-3841.16365
   Khalifi S, 2015, NITRIC OXIDE-BIOL CH, V44, P24, DOI 10.1016/j.niox.2014.11.011
   Khambata RS, 2017, P NATL ACAD SCI USA, V114, pE550, DOI 10.1073/pnas.1613063114
   Khazrai YM, 2014, DIABETES-METAB RES, V30, P24, DOI 10.1002/dmrr.2515
   Lai YC, 2016, CIRCULATION, V133, P717, DOI 10.1161/CIRCULATIONAHA.115.018935
   Larsen FJ, 2006, NEW ENGL J MED, V355, P2792, DOI 10.1056/NEJMc062800
   Li T, 2016, FOOD NUTR RES, V60, DOI 10.3402/fnr.v60.32010
   Lundberg JO, 2008, NAT REV DRUG DISCOV, V7, DOI [10.1038/nrd2466-c2, 10.1038/nrd2466]
   Lundberg JO, 2018, CELL METAB, V28, P9, DOI 10.1016/j.cmet.2018.06.007
   Lundberg JO, 2013, GUT, V62, P616, DOI 10.1136/gutjnl-2011-301649
   Ma LS, 2018, AGING DIS, V9, P938, DOI 10.14336/AD.2017.1207
   Marhamati M, 2021, CURR PHARM BIOTECHNO, V22, P1325, DOI 10.2174/1389201021666201203160012
   Mirmiran P, 2010, PUBLIC HEALTH NUTR, V13, P654, DOI 10.1017/S1368980009991698
   Mirrazavi ZS., 2024, VARIOUS TYPES FASTIN, P519
   Ohtake K, 2015, NITRIC OXIDE-BIOL CH, V44, P31, DOI 10.1016/j.niox.2014.11.009
   Pennington JAT, 1998, FOOD CONTROL, V9, P385, DOI 10.1016/S0956-7135(98)00019-X
   Rathod KS, 2016, MOL NUTR FOOD RES, V60, P185, DOI 10.1002/mnfr.201500313
   Santamaria P., 2006, Journal of the Science of Food and Agriculture, V86, P10, DOI 10.1002/jsfa.2351
   Siervo M, 2013, J NUTR, V143, P818, DOI 10.3945/jn.112.170233
   Singamsetty S, 2015, J PHYSIOL-LONDON, V593, P3135, DOI 10.1113/JP270386
   Sobko T, 2010, NITRIC OXIDE-BIOL CH, V22, P136, DOI 10.1016/j.niox.2009.10.007
   Soin A, 2018, PAIN PHYSICIAN, V21, P179
   Srour B, 2023, PLOS MED, V20, DOI 10.1371/journal.pmed.1004149
   Stokes KY, 2009, AM J PHYSIOL-HEART C, V296, pH1281, DOI 10.1152/ajpheart.01291.2008
   Susin J, 2006, FOOD ADDIT CONTAM A, V23, P385, DOI 10.1080/02652030600573715
   TRICKER AR, 1991, MUTAT RES, V259, P277, DOI 10.1016/0165-1218(91)90123-4
   von Elm E, 2007, PLOS MED, V4, P1623, DOI [10.1371/journal.pmed.0040296, 10.1371/journal.pmed.0040297, 10.1016/S0140-6736(07)61602-X]
   Webb AJ, 2008, HYPERTENSION, V51, P784, DOI 10.1161/HYPERTENSIONAHA.107.103523
NR 65
TC 1
Z9 1
U1 1
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-7486
EI 1465-3478
J9 INT J FOOD SCI NUTR
JI Int. J. Food Sci. Nutr.
PD OCT 2
PY 2024
VL 75
IS 7
BP 695
EP 706
DI 10.1080/09637486.2024.2395817
EA AUG 2024
PG 12
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA I4N3R
UT WOS:001300545000001
PM 39192837
DA 2025-06-11
ER

PT J
AU Mangge, H
   Zelzer, S
   Puerstner, P
   Schnedl, WJ
   Reeves, G
   Postolache, TT
   Weghuber, D
AF Mangge, Harald
   Zelzer, Sieglinde
   Puerstner, Peter
   Schnedl, Wolfgang J.
   Reeves, Gloria
   Postolache, Teodor T.
   Weghuber, Daniel
TI Uric Acid Best Predicts Metabolically Unhealthy Obesity With Increased
   Cardiovascular Risk in Youth and Adults
SO OBESITY
LA English
DT Article
ID SUBCUTANEOUS ADIPOSE-TISSUE; MUSCLE-CELL-PROLIFERATION; CARDIOMETABOLIC
   RISK; OXIDATIVE STRESS; ATHEROSCLEROSIS; CIRCUMFERENCE; DEFINITION;
   THICKNESS; DISEASE; BODY
AB Objective: The obesity prevalence is growing worldwide and largely responsible for cardiovascular disease, the most common cause of death in the western world. The rationale of this study was to distinguish metabolically healthy from unhealthy overweight/obese young and adult patients as compared to healthy normal weight age matched controls by an extensive anthropometric, laboratory, and sonographic vascular assessment.
   Design and Methods: Three hundred fifty five young [8 to <= 18 years, 299 overweight/obese(ow/ob), 56 normal weight (nw)] and 354 adult [>18-60 years, 175 (ow/ob), 179 nw)] participants of the STYJOBS/EDECTA (STYrian Juvenile Obesity Study/Early DEteCTion of Atherosclerosis) cohort were analyzed. STYJOBS/EDECTA (NCT00482924) is a crossectional study to investigate metabolic/cardiovascular risk profiles in normal and ow/ob people free of disease except metabolic syndrome (MetS).
   Results: From 299 young ow/ob subjects (8-<= 18 years), 108 (36%), and from 175 adult ow/ob subjects (>18-60 years), 79 (45%) had positive criteria for MetS. In both age groups, prevalence of MetS was greater among males. Overweight/obese subjects were divided into "healthy" (no MetS criterion except anthropometry fulfilled) and "unhealthy" (MetS positive). Although percentage body fat did not differ between "healthy" and "unhealthy" ow/ob, nuchal and visceral fat were significantly greater in the "unhealthy" group which had also significantly higher values of carotid intima media thickness (IMT). With MetS as the dependent variable, two logistic regressions including juveniles <= 18 years or adults >18 years were performed. The potential predictor variables selected with the exception of age and gender by t test comparisons included IMT, ultrasensitive c-reactive protein (US-CRP), IL-6, malondialdehyde (MDA), oxidized LDL, leptin, adiponectin, uric acid (UA), aldosterone, cortisol, transaminases, fibrinogen. In both groups, uric acid and in adults only, leptin and adiponectin, turned out as the best predictor.
   Conclusion: Serum levels of UA are a significant predictor of unhealthy obesity in juveniles and adults.
C1 [Mangge, Harald; Zelzer, Sieglinde] Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Graz, Austria.
   [Puerstner, Peter] Med Univ Graz, Dept Obstet & Gynecol, Endocrine Lab, Graz, Austria.
   [Reeves, Gloria] Univ Maryland, Sch Med, Dept Psychiat, Child & Adolescent Psychiat Div, Baltimore, MD 21201 USA.
   [Postolache, Teodor T.] Univ Maryland, Sch Med, Dept Psychiat, Mood & Anxiety Program, Baltimore, MD 21201 USA.
   [Weghuber, Daniel] Paracelsus Med Sch Salzburg, Dept Pediat, Salzburg, Austria.
C3 Medical University of Graz; Medical University of Graz; University
   System of Maryland; University of Maryland Baltimore; University System
   of Maryland; University of Maryland Baltimore; Paracelsus Private
   Medical University
RP Mangge, H (corresponding author), Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Graz, Austria.
EM harald.mangge@klinikum-graz.at
RI Weghuber, Daniel/AAN-1422-2020
OI Weghuber, Daniel/0000-0002-4389-0379; Schnedl,
   Wolfgang/0000-0002-5212-5230; Mangge, Harald/0000-0003-4067-247X;
   Postolache, Teodor/0000-0001-6056-4244
FU "Zukunftsfond Steiermark" Project "STYJOBS-Extension''; Austrian
   Nano-Initiative as part of the Nano-Health project [0200]; Austrian FWF
   (Fonds zur Forderung der Wissenschaftlichen Forschung) [N212-NAN];
   STYJOBS EDECTA Cohort
FX This work was funded by the "Zukunftsfond Steiermark" Project
   "STYJOBS-Extension''. Furthermore, the Austrian Nano-Initiative
   co-financed this work as part of the Nano-Health project (no. 0200), the
   sub-project NANO-PLAQUE being financed by the Austrian FWF (Fonds zur
   Forderung der Wissenschaftlichen Forschung, Project no. N212-NAN).
   Financial support of a technician and consumables associated with the
   set up of the STYJOBS EDECTA Cohort.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alvarez-Lario B, 2011, QJM-INT J MED, V104, P1015, DOI 10.1093/qjmed/hcr159
   Ärnlöv J, 2010, CIRCULATION, V121, P230, DOI 10.1161/CIRCULATIONAHA.109.887521
   Baker JF, 2005, AM J MED, V118, P816, DOI 10.1016/j.amjmed.2005.03.043
   Baldwin W, 2011, DIABETES, V60, P1258, DOI 10.2337/db10-0916
   Calori G, 2011, DIABETES CARE, V34, P210, DOI 10.2337/dc10-0665
   Corry DB, 2008, J HYPERTENS, V26, P269, DOI 10.1097/HJH.0b013e3282f240bf
   Hongo M, 2010, CIRC J, V74, P1570, DOI 10.1253/circj.CJ-09-0837
   Irizarry MC, 2009, NEURODEGENER DIS, V6, P23, DOI 10.1159/000170883
   Iwao S, 2001, OBES RES, V9, P685, DOI 10.1038/oby.2001.93
   Kiechl S, 1999, ARTERIOSCL THROM VAS, V19, P1491, DOI 10.1161/01.ATV.19.6.1491
   Kim TS, 2006, INT J GERIATR PSYCH, V21, P344, DOI 10.1002/gps.1469
   Klöting N, 2010, AM J PHYSIOL-ENDOC M, V299, pE506, DOI 10.1152/ajpendo.00586.2009
   Kutzing MK, 2008, J PHARMACOL EXP THER, V324, P1, DOI 10.1124/jpet.107.129031
   Mangge H, 2008, OBESITY, V16, P2578, DOI 10.1038/oby.2008.439
   Mangge H, 2009, ATHEROSCLEROSIS, V203, P277, DOI 10.1016/j.atherosclerosis.2008.06.013
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Möller R, 2000, ANN HUM BIOL, V27, P47, DOI 10.1080/030144600282370
   Pajunen P, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-754
   PIGNOLI P, 1986, CIRCULATION, V74, P1399, DOI 10.1161/01.CIR.74.6.1399
   Pilz S, 2005, J CLIN ENDOCR METAB, V90, P4792, DOI 10.1210/jc.2005-0167
   Preis SR, 2010, J CLIN ENDOCR METAB, V95, P3701, DOI 10.1210/jc.2009-1779
   Primeau V., 2010, International journal of obesity, V35, P971
   RAO GN, 1991, J BIOL CHEM, V266, P8604
   Roob JM, 2000, J AM SOC NEPHROL, V11, P539, DOI 10.1681/ASN.V113539
   Stewart ST, 2009, NEW ENGL J MED, V361, P2252, DOI 10.1056/NEJMsa0900459
   Taksali SE, 2008, DIABETES, V57, P367, DOI 10.2337/db07-0932
   Tsouli SG, 2006, METABOLISM, V55, P1293, DOI 10.1016/j.metabol.2006.05.013
   Zelzer S, 2009, CLIN CHIM ACTA, V406, P62, DOI 10.1016/j.cca.2009.05.009
   Zimmet P, 2005, REV ESP CARDIOL, V58, P1371, DOI 10.1016/S1885-5857(06)60742-1
NR 31
TC 103
Z9 103
U1 1
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD JAN
PY 2013
VL 21
IS 1
BP E71
EP E77
DI 10.1002/oby.20061
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 187AE
UT WOS:000322086900010
PM 23401248
OA Bronze
DA 2025-06-11
ER

PT J
AU Canz, MJ
   Baguña-Torres, J
   Huerta, J
   Isla-Magrané, H
   Zufiaurre-Seijo, M
   Salas, A
   Hernandez, C
   Simó, R
   García-Arumí, J
   Herance, JR
   Bogdanov, P
   Duarri, A
AF Canz, Maria Jose
   Baguna-Torres, Julia
   Huerta, Jordi
   Isla-Magrane, Helena
   Zufiaurre-Seijo, Maddalen
   Salas, Anna
   Hernandez, Cristina
   Simo, Rafael
   Garcia-Arumi, Jose
   Herance, Jose Raul
   Bogdanov, Patricia
   Duarri, Anna
TI Diabetic retinopathy features in lund MetS rats
SO EXPERIMENTAL EYE RESEARCH
LA English
DT Article
DE Diabetic retinopathy; Neurodegeneration; Neurovascular unit; Metabolic
   syndrome; Retina
ID OXIDATIVE STRESS; ADHESION MOLECULE-1; MACULAR EDEMA; COLOR-VISION;
   CELL; DYSFUNCTION; RETINA; MODELS; GENE
AB The Lund MetS rat (BBDR.cg-Leprdb/db.cp/LundRj) is a novel animal model that has a congenic leptin receptor deficiency (LepR-/-) and males exhibit a variety of metabolic abnormalities mimicking the human metabolic syndrome, including hyperglycemia, dyslipidemia, severe obesity, and a type 2 diabetes-like condition from weeks of age. However, whether Lund MetS rats (LM rats) develop diabetic retinopathy is still unknown. The purpose is to investigate the features of diabetic retinopathy in this model. In this study, male LM rats aged 15 and 30 weeks were analyzed for pathological retinal changes, including vasculopathy, inflammation, reactive gliosis, oxidative stress, and neurodegeneration features on the retinas by histological, immunohistochemical, and gene and protein expression analysis. Compared with the non-diabetic LM rats, diabetic LM rats, mainly 30 weeks of age, had a decrease in retinal thickness and loss of retinal ganglion cells and photoreceptors, indicating retinal neurodegeneration. They also presented an increase in VEGF-A expression, Endra, Icam-1, Vcam-1, and Endrb vascular genes, and albumin suggesting neurovascular unit dysfunction. Furthermore, retinas presented reactive gliosis and infiltration of microglia, TNF-alpha-positive vessels and expressed elevated levels of inflammatory genes Tnf-alpha, IL-18 and IL-6, and oxidative stress markers Sod2 and 8-hydroxy-2-deoxyguanosine (8-OHdG). Our results suggest that diabetic LM rats reproduce the early neurodegenerative and altered neurovascular features that also occur in the human diabetic eye.
C1 [Canz, Maria Jose; Isla-Magrane, Helena; Zufiaurre-Seijo, Maddalen; Salas, Anna; Garcia-Arumi, Jose; Duarri, Anna] Vall dHebron Res Inst, Ophthalmol Res Grp, Barcelona 08035, Spain.
   [Baguna-Torres, Julia; Herance, Jose Raul; Bogdanov, Patricia] Vall dHebron Res Inst, Med Mol Imaging Res Grp, Barcelona 08035, Spain.
   [Huerta, Jordi; Hernandez, Cristina; Simo, Rafael; Bogdanov, Patricia] Vall dHebron Res Inst, Diabet & Metab Res Unit, Barcelona 08035, Spain.
   [Hernandez, Cristina; Simo, Rafael; Bogdanov, Patricia] Inst Salud Carlos III ISCIII, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid 28029, Spain.
   [Garcia-Arumi, Jose] Univ Autonoma Barcelona, Dept Med & Ophthalmol, Bellaterra 08193, Spain.
   [Herance, Jose Raul] Inst Salud Carlos III ISCIII, CIBER BBN ISCIII, Madrid 28040, Spain.
C3 Autonomous University of Barcelona; Hospital Universitari Vall d'Hebron;
   Vall d'Hebron Institut de Recerca (VHIR); Autonomous University of
   Barcelona; Hospital Universitari Vall d'Hebron; Vall d'Hebron Institut
   de Recerca (VHIR); Autonomous University of Barcelona; Hospital
   Universitari Vall d'Hebron; Vall d'Hebron Institut de Recerca (VHIR);
   CIBER - Centro de Investigacion Biomedica en Red; CIBERDEM; Autonomous
   University of Barcelona; CIBER - Centro de Investigacion Biomedica en
   Red; CIBERBBN
RP Duarri, A (corresponding author), Vall dHebron Res Inst, Ophthalmol Res Grp, Barcelona 08035, Spain.; Bogdanov, P (corresponding author), Vall dHebron Res Inst, Diabet & Metab Res Unit, Barcelona 08035, Spain.
EM patricia.bogdanov@vhir.org; anna.duarri@vhir.org
RI Camacho, José/Q-3416-2016; Bogdanov, Patricia/AAF-7831-2021; Torres,
   Julia/JHT-7843-2023; Isla, Helena/HNJ-5145-2023; Duarri,
   Anna/K-2811-2017
OI Bogdanov, Patricia/0000-0003-0669-4958; Herance, Jose
   Raul/0000-0001-7178-3290; Baguna Torres, Julia/0000-0001-8621-3549
FU Instituto de Salud Carlos III [PI20/01588, PI22/01747]; Agencia Gestio
   Ajuts Universitaris i de Recerca [2017SGR1303]; Ministerio de Ciencia
   Innovacion, Gobierno de Espana [PID2022-138544OB-100,
   PID2021-122807OB-C32]
FX This research project was funded by grants from Instituto de Salud
   Carlos III (PI20/01588 and PI22/01747), Agencia Gestio Ajuts
   Universitaris i de Recerca (2017SGR1303), and Ministerio de Ciencia
   Innovacion, Gobierno de Espana (PID2022-138544OB-100 and
   PID2021-122807OB-C32).
CR Ali Z, 2020, INVEST OPHTH VIS SCI, V61, DOI 10.1167/iovs.61.2.43
   Alizadeh Y, 2022, J CURR OPHTHALMOL, V34, P312, DOI 10.4103/joco.joco_42_22
   Anderson PJB, 2008, CLIN OPHTHALMOL, V2, P801
   Arrigo A, 2022, ANN MED, V54, P1089, DOI 10.1080/07853890.2022.2064541
   Badia A, 2023, ACS NANO, V17, P910, DOI 10.1021/acsnano.2c05447
   Berglund L, 2014, FASEB J, V28
   Birben E, 2012, WORLD ALLERGY ORGAN, V5, P9, DOI 10.1097/WOX.0b013e3182439613
   Bogdanov P, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10020465
   Bogdanov P, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0097302
   Briand F., 2022, Nephrol. Dial. Transplant., V37, DOI 10
   Chaurasia S, 2023, CUREUS J MED SCIENCE, V15, DOI 10.7759/cureus.49211
   Chen YL, 2019, DIABETES, V68, P1624, DOI 10.2337/db19-0069
   CHIHARA E, 1993, OPHTHALMOLOGY, V100, P1147
   Chou J, 2014, ADV EXP MED BIOL, V801, P669, DOI 10.1007/978-1-4614-3209-8_84
   Cipres M, 2022, Arch Soc Esp Oftalmol (Engl Ed), V97, P205, DOI 10.1016/j.oftale.2022.02.009
   CLARK JB, 1983, P SOC EXP BIOL MED, V173, P68
   Cubillos S, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25031610
   DALEY ML, 1987, DIABETES CARE, V10, P777, DOI 10.2337/diacare.10.6.777
   Daruich A, 2018, PROG RETIN EYE RES, V63, P20, DOI 10.1016/j.preteyeres.2017.10.006
   Dong QY, 2008, EUR J OPHTHALMOL, V18, P94, DOI 10.1177/112067210801800116
   Dubroca C, 2022, EUR HEART J, V43, P2947
   Énzsöly A, 2014, INVEST OPHTH VIS SCI, V55, P3686, DOI 10.1167/iovs.13-13562
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Farnoodian M, 2016, AM J PHYSIOL-CELL PH, V311, pC418, DOI 10.1152/ajpcell.00001.2016
   Fosmark DS, 2007, ACTA OPHTHALMOL SCAN, V85, P618, DOI 10.1111/j.1600-0420.2007.00913.x
   Frey T, 2011, ANTIOXID REDOX SIGN, V15, P1271, DOI 10.1089/ars.2011.3906
   Gao BB, 2008, J PROTEOME RES, V7, P2516, DOI 10.1021/pr800112g
   Gardiner T.A., 2022, International Journal of Translational Medicine, V2, P26, DOI [10.3390/ijtm2010003, DOI 10.3390/IJTM2010003]
   Goldberg RB, 2009, J CLIN ENDOCR METAB, V94, P3171, DOI 10.1210/jc.2008-2534
   Gomez M., 2014, FASEB J., V28
   Gomez M.F., 2015, Patent No. [WO2015044339A1, 2015044339]
   Guo L, 2022, FRONT CELL NEUROSCI, V16, DOI 10.3389/fncel.2022.804782
   Hajdú RI, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-46879-1
   Hamadneh T, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.10871
   Jolic M, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-42379-5
   Joussen AM, 2002, AM J PATHOL, V160, P501, DOI 10.1016/S0002-9440(10)64869-9
   Kang QZ, 2020, REDOX BIOL, V37, DOI 10.1016/j.redox.2020.101799
   Katsuda Y, 2014, EXP ANIM TOKYO, V63, P121, DOI 10.1538/expanim.63.121
   Kern TS, 2008, J PHYSIOL-LONDON, V586, P4401, DOI 10.1113/jphysiol.2008.156695
   Khalfaoui T, 2008, J MOL HISTOL, V39, P243, DOI 10.1007/s10735-007-9159-5
   King AJF, 2012, BRIT J PHARMACOL, V166, P877, DOI 10.1111/j.1476-5381.2012.01911.x
   Kinnear P R, 1972, Trans Ophthalmol Soc U K, V92, P69
   Kwitek AE, 2019, METHODS MOL BIOL, V2018, P269, DOI 10.1007/978-1-4939-9581-3_13
   LAKOWSKI R, 1973, OPHTHALMIC RES, V4, P145
   Le D, 2022, RETINA-J RET VIT DIS, V42, P1442, DOI 10.1097/IAE.0000000000003473
   Lee R, 2015, EYE VISION, V2, DOI 10.1186/s40662-015-0026-2
   Li M, 2023, MOL MED REP, V28, DOI 10.3892/mmr.2023.13072
   Lin WJ, 2014, AUTOPHAGY, V10, P1692, DOI 10.4161/auto.36076
   Lin YJ, 2024, PHARMACEUTICALS-BASE, V17, DOI 10.3390/ph17070837
   Lorenzi M, 2001, DIABETOLOGIA, V44, P791, DOI 10.1007/s001250100544
   Marumo T, 1999, DIABETES, V48, P1131, DOI 10.2337/diabetes.48.5.1131
   Micheletti C, 2023, BONE, V172, DOI 10.1016/j.bone.2023.116747
   Miyamoto N, 2007, DIABETOLOGIA, V50, P461, DOI 10.1007/s00125-006-0539-2
   Ng DSK, 2016, CLIN EXP OPHTHALMOL, V44, P243, DOI 10.1111/ceo.12724
   Nijim W, 2023, FRONT OPHTHALMOL-SWI, V3, DOI 10.3389/fopht.2023.1230581
   Nowak M, 2008, CLIN EXP MED, V8, P159, DOI 10.1007/s10238-008-0173-z
   OSTROY SE, 1994, INVEST OPHTH VIS SCI, V35, P3905
   Park SH, 2003, DIABETOLOGIA, V46, P1260, DOI 10.1007/s00125-003-1177-6
   Polewik K, 2023, BIOLOGY-BASEL, V12, DOI 10.3390/biology12020262
   Quiroz J, 2021, ANN TRANSL MED, V9, DOI 10.21037/atm-20-6737
   Rajagopal R., 2024, Ophthalmology Science, DOI [10.1016/j.xops.2024.100591,100591, DOI 10.1016/J.XOPS.2024.100591,100591]
   Ramos H, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11071418
   Ramos H, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9090846
   Rungger-Brändle E, 2000, INVEST OPHTH VIS SCI, V41, P1971
   Salas A, 2021, MOL THER-METH CLIN D, V20, P688, DOI 10.1016/j.omtm.2021.02.006
   Santos AR, 2017, DIABETES, V66, P2503, DOI 10.2337/db16-1453
   Simó R, 2023, DIABETOLOGIA, V66, P1614, DOI 10.1007/s00125-023-05940-5
   Simó R, 2022, ASIA-PAC J OPHTHALMO, V11, P160, DOI 10.1097/APO.0000000000000510
   Simó R, 2021, PHARMACEUTICS, V13, DOI 10.3390/pharmaceutics13081320
   Sohn EH, 2016, P NATL ACAD SCI USA, V113, pE2655, DOI 10.1073/pnas.1522014113
   Szabó K, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-09068-6
   Talu S, 2021, WORLD J DIABETES, V12, P437, DOI 10.4239/wjd.v12.i4.437
   Tan CS, 2012, INVEST OPHTH VIS SCI, V53, P261, DOI 10.1167/iovs.11-8782
   Teo ZL, 2021, OPHTHALMOLOGY, V128, P1580, DOI 10.1016/j.ophtha.2021.04.027
   TRICK GL, 1988, OPHTHALMOLOGY, V95, P693
   Wang ZY, 2024, FRONT ENDOCRINOL, V15, DOI 10.3389/fendo.2024.1347864
   Wei LD, 2022, FRONT CELL DEV BIOL, V10, DOI 10.3389/fcell.2022.963615
   Wong TY, 2016, NAT REV DIS PRIMERS, V2, DOI 10.1038/nrdp.2016.12
   Wong TY, 2023, INVEST OPHTH VIS SCI, V64, DOI 10.1167/iovs.64.15.47
   Xia T, 2017, VISION RES, V139, P72, DOI 10.1016/j.visres.2017.02.006
   Xiong SY, 2020, AM J OPHTHALMOL, V213, P46, DOI 10.1016/j.ajo.2020.01.003
   Yang JF, 2023, EXP EYE RES, V232, DOI 10.1016/j.exer.2023.109496
   Yang Q, 2015, J OPHTHALMOL, V2015, DOI 10.1155/2015/757412
   Yu JY, 2016, DIABETOLOGIA, V59, P2026, DOI 10.1007/s00125-016-4012-6
   Zhang XY, 2014, CELL BIOSCI, V4, DOI 10.1186/2045-3701-4-27
   ZHANG YY, 1994, NATURE, V372, P425, DOI 10.1038/372425a0
NR 86
TC 1
Z9 1
U1 4
U2 4
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0014-4835
EI 1096-0007
J9 EXP EYE RES
JI Exp. Eye Res.
PD MAR
PY 2025
VL 252
AR 110274
DI 10.1016/j.exer.2025.110274
EA FEB 2025
PG 13
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA X8F2C
UT WOS:001427630400001
PM 39923911
OA hybrid
DA 2025-06-11
ER

PT J
AU ON'Kin, JBKL
   Longo-Mbenza, B
   Tchokonte-Nana, V
   Okwe, AN
   Kabangu, NK
AF ON'Kin, Jean Bosco Kasiam Lasi
   Longo-Mbenza, Benjamin
   Tchokonte-Nana, Venant
   Okwe, Augustin Nge
   Kabangu, Nelly Kangola
TI Hyperbolic relation between beta-cell function and insulin sensitivity
   for type 2 diabetes mellitus, malaria, influenza, Helicobacter
   pylori, Chlamydia pneumoniae, and hepatitis C virus
   infection-induced inflammation/oxidative stress and temporary insulin
   resistance in Central Africans
SO TURKISH JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE Insulin resistance; type 2 diabetes; inflammation; sub-Saharan Africa;
   homeostatic model assessment
ID HOMEOSTASIS MODEL ASSESSMENT; METABOLIC SYNDROME; GLUCOSE-TOLERANCE;
   HEART-DISEASE; RISK-FACTORS; PREVALENCE; STROKE; ATHEROSCLEROSIS;
   PHENOTYPE; FREQUENCY
AB Background/aim: We calculated the homeostatic model assessment (HOMA) for estimating insulin sensitivity and beta-cell function in normal, healthy nondiabetics with infections (malaria, influenza, HIV, Helicobacter pylori, Chlamydia pneumoniae, and hepatitis C virus), type 2 diabetic black patients, and healthy controls from Kinshasa, DR Congo.
   Materials and methods: A case-control study was carried out between 2006 and 2007 for black Central African participants managed for HOMA.
   Results: In total, 219 patients and 110 healthy controls were matched for sex and age. The hyperbolic product for 85 infected patients occupied an intermediate position between the hyperbolic product for 110 controls and that of 134 type 2 diabetics. Inflammation/oxidative stress was present in all infected patients, as well as in the type 2 diabetics. Of the patients, 39.3% and 49.8% had insulin resistance and metabolic syndrome, respectively. Insulin resistance was more prevalent in nondiabetics with inflammation/oxidative stress (47.1%; P = 0.041) than in type 2 diabetics (34.3%). Type 2 diabetics had higher insulin sensitivity and lower beta-cell function but a similar HOMA-IR score.
   Conclusion: We recommend the assessment of insulin resistance in Central African patients with severe infections and type 2 diabetes.
C1 [ON'Kin, Jean Bosco Kasiam Lasi; Longo-Mbenza, Benjamin] Univ Kinshasa, Dept Internal Med, Kinshasa, DEM REP CONGO.
   [Longo-Mbenza, Benjamin] Univ President Kasa Vubu, Boma, DEM REP CONGO.
   [Longo-Mbenza, Benjamin; Okwe, Augustin Nge; Kabangu, Nelly Kangola] LOMO Med Ctr, Biostat Unit, Kinshasa, DEM REP CONGO.
   [Longo-Mbenza, Benjamin; Okwe, Augustin Nge; Kabangu, Nelly Kangola] Heart Africa Ctr Cardiol, Kinshasa, DEM REP CONGO.
   [Tchokonte-Nana, Venant] Stellenbosch Univ, Fac Med & Hlth Sci, Islet & MSK Res Grp, Tygerberg, South Africa.
C3 Universite de Kinshasa; Stellenbosch University
RP Tchokonte-Nana, V (corresponding author), Stellenbosch Univ, Fac Med & Hlth Sci, Islet & MSK Res Grp, Tygerberg, South Africa.
EM venant.tnana@gmail.com
RI Tchokonte-Nana, Venant/L-3364-2016
OI Tchokonte-Nana, Venant/0000-0003-2240-3735
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Balkau B, 2002, DIABETES METAB, V28, P364
   Barzilay JI, 2007, ARCH INTERN MED, V167, P635, DOI 10.1001/archinte.167.7.635
   Bergman RN, 2002, MT SINAI J MED, V69, P280
   Bergman RN, 1996, DIABETIC MED, V13, pS67
   Bonora E, 2000, DIABETES CARE, V23, P57, DOI 10.2337/diacare.23.1.57
   Dehout F, 2008, DIABETES METAB SYND, V2, P5, DOI 10.1016/j.dsx.2007.11.008
   Duncan BB, 2003, DIABETES, V52, P1799, DOI 10.2337/diabetes.52.7.1799
   Estein SE, 1999, CIRCULATION, V100, pe20
   Fernández-Real JM, 2006, DIABETES CARE, V29, P1058, DOI 10.2337/dc05-2068
   Fezeu L, 2007, ATHEROSCLEROSIS, V193, P70, DOI 10.1016/j.atherosclerosis.2006.08.037
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Gavin JR, 1999, DIABETES CARE, V22, pS5
   Gu DF, 2005, LANCET, V365, P1398, DOI 10.1016/S0140-6736(05)66375-1
   Guerrero-Romero F, 2006, EUR J CLIN INVEST, V36, P796, DOI 10.1111/j.1365-2362.2006.01728.x
   Hermans MP, 2007, Diabetes Vasc Dis Res, V4, pS7, DOI [10.3132/dvdr.2007.019, DOI 10.3132/DVDR.2007.019]
   Hermans MP, 2006, LOUVAIN MED, V125, pS82
   Kahn BB, 2000, J CLIN INVEST, V106, P473, DOI 10.1172/JCI10842
   KAHN SE, 1993, DIABETES, V42, P1663, DOI 10.2337/diabetes.42.11.1663
   Kasiam Lasi On'kin J B, 2007, Cardiovasc J Afr, V18, P300
   Le Roith D, 2001, DIABETES CARE, V24, P588, DOI 10.2337/diacare.24.3.588
   Longo-Mbenza B, 2007, INT J CARDIOL, V121, P229, DOI 10.1016/j.ijcard.2006.12.003
   Longo-Mbenza B, 2007, West Afr J Med, V26, P183
   Longo-Mbenza B, 1999, INT J CARDIOL, V71, P17, DOI 10.1016/S0167-5273(99)00097-2
   Longo-Mbenza B, 1999, ANN MED INTERNE, V150, P171
   Longo-Mbenza B, 2000, REV EPIDEMIOL SANTE, V48, P31
   Longo-Mbenza B, 2008, EUR J CARDIOV PREV R, V15, P503, DOI 10.1097/HJR.0b013e3282f21640
   Longokolo MM, 2008, THESIS
   LongoMbenza B, 1997, ANN CARDIOL ANGEIOL, V46, P81
   Mantzoros C S, 1995, Adv Endocrinol Metab, V6, P193
   Manuthu E M, 2008, East Afr Med J, V85, P10
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mbenza L., 2008, International Journal of Diabetes Metabolism, V16, P17
   Meigs JB, 1998, ANN INTERN MED, V128, P524, DOI 10.7326/0003-4819-128-7-199804010-00002
   MOLLER DE, 1991, NEW ENGL J MED, V325, P938
   Nsenga JN, 2007, J AFR HEPAT GASTROEN, V1, P87, DOI 10.1007/s12157-007-0021-x
   Pacini G, 2006, NUTR METAB CARDIOVAS, V16, pS22, DOI 10.1016/j.numecd.2005.10.014
   Prasad A, 2002, CIRCULATION, V106, P184, DOI 10.1161/01.CIR.0000021125.83697.21
   Preumont V, 2007, DIABETES CARE, V30, P1187, DOI 10.2337/dc06-1915
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Reilly MP, 2003, CIRCULATION, V108, P1546, DOI 10.1161/01.CIR.0000088846.10655.E0
   Sobngwi E, 2001, DIABETES METAB, V27, P628
   Sumner AE, 2005, METABOLISM, V54, P902, DOI 10.1016/j.metabol.2005.03.001
   Tataranni PA, 2005, DIABETES, V54, P917, DOI 10.2337/diabetes.54.4.917
   Yokoyama H, 2004, J CLIN ENDOCR METAB, V89, P1481, DOI 10.1210/jc.2003-031374
NR 45
TC 5
Z9 5
U1 0
U2 3
PU Tubitak Scientific & Technological Research Council Turkey
PI ANKARA
PA ATATURK BULVARI NO 221, KAVAKLIDERE, TR-06100 ANKARA, TURKIYE
SN 1300-0144
EI 1303-6165
J9 TURK J MED SCI
JI Turk. J. Med. Sci.
PY 2017
VL 47
IS 6
BP 1834
EP 1841
DI 10.3906/sag-1608-48
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FR2GD
UT WOS:000418884300025
PM 29306246
OA Bronze
DA 2025-06-11
ER

PT J
AU Di Marzo, V
AF Di Marzo, Vincenzo
TI Targeting the endocannabinoid system: to enhance or reduce?
SO NATURE REVIEWS DRUG DISCOVERY
LA English
DT Review
ID ACID AMIDE HYDROLASE; CB1 RECEPTOR ANTAGONIST; TRANSPORT INHIBITOR
   AM404; ENDOGENOUS LIGAND 2-ARACHIDONOYLGLYCEROL; PERIPHERAL CANNABINOID
   RECEPTOR; CARDIOMETABOLIC RISK-FACTORS; ALLERGIC CONTACT-DERMATITIS;
   STRESS-INDUCED ACTIVATION; ANANDAMIDE-TRANSPORT; IN-VIVO
AB As our understanding of the endocannabinoids improves, so does the awareness of their complexity. During pathological states, the levels of these mediators in tissues change, and their effects vary from those of protective endogenous compounds to those of dysregulated signals. These observations led to the discovery of compounds that either prolong the lifespan of endocannabinoids or tone down their action for the potential future treatment of pain, affective and neurodegenerative disorders, gastrointestinal inflammation, obesity and metabolic dysfunctions, cardiovascular conditions and liver diseases. When moving to the clinic, however, the pleiotropic nature of endocannabinoid functions will require careful judgement in the choice of patients and stage of the disorder for treatment.
C1 CNR, Inst Biomol Chem, Endocannabinoid Res Grp, I-80078 Naples, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR)
RP Di Marzo, V (corresponding author), CNR, Inst Biomol Chem, Endocannabinoid Res Grp, Via Campi,Flegrei 34, I-80078 Naples, Italy.
EM vdimarzo@icmib.na.cnr.it
RI Di Marzo, Vincenzo/AAD-7742-2019
OI Di Marzo, Vincenzo/0000-0002-1490-3070
CR ABOUABDELLAH A, 2005, Patent No. 20050182130
   Addy C, 2008, J CLIN PHARMACOL, V48, P418, DOI 10.1177/0091270008314467
   AGRAWAL N, 2007, NAT NEUROSCI, V10, P870
   Ahn K, 2007, BIOCHEMISTRY-US, V46, P13019, DOI 10.1021/bi701378g
   Alexander JP, 2006, J AM CHEM SOC, V128, P9699, DOI 10.1021/ja062999h
   Alexander SPH, 2007, BRIT J PHARMACOL, V152, P602, DOI 10.1038/sj.bjp.0707456
   Ashton JC, 2007, CURR VASC PHARMACOL, V5, P175
   Baker D, 2001, FASEB J, V15, P300, DOI 10.1096/fj.00-0399fje
   Bátkai S, 2004, CIRCULATION, V110, P1996, DOI 10.1161/01.CIR.0000143230.23252.D2
   Bátkai S, 2001, NAT MED, V7, P827, DOI 10.1038/89953
   Batkai S, 2007, AM J PHYSIOL-HEART C, V293, pH1689, DOI 10.1152/ajpheart.00538.2007
   Bátkai S, 2007, FASEB J, V21, P1788, DOI 10.1096/fj.06-7451com
   Beltramo M, 1997, SCIENCE, V277, P1094, DOI 10.1126/science.277.5329.1094
   Benito C, 2003, J NEUROSCI, V23, P11136
   Bifulco M, 2004, FASEB J, V18, P1606, DOI 10.1096/fj.04-1754fje
   Bifulco M, 2007, ONCOL REP, V17, P813
   Bilsland LG, 2006, FASEB J, V20, P1003, DOI 10.1096/fj.05-4743fje
   Bisogno T, 1998, BIOCHEM BIOPH RES CO, V248, P515, DOI 10.1006/bbrc.1998.8874
   Bisogno T, 2006, BBA-MOL CELL BIOL L, V1761, P205, DOI 10.1016/j.bbalip.2005.12.009
   Bisogno T, 2007, PHARMACOL RES, V56, P428, DOI 10.1016/j.phrs.2007.09.002
   Blankman JL, 2007, CHEM BIOL, V14, P1347, DOI 10.1016/j.chembiol.2007.11.006
   Bortolato M, 2006, NEUROPSYCHOPHARMACOL, V31, P2652, DOI 10.1038/sj.npp.1301061
   Braida D, 2007, EUR J PHARMACOL, V555, P156, DOI 10.1016/j.ejphar.2006.10.038
   Cabranes A, 2005, NEUROBIOL DIS, V20, P207, DOI 10.1016/j.nbd.2005.03.002
   Cahill K, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005353.pub3
   Cao XB, 2007, J PHARMACOL EXP THER, V323, P318, DOI 10.1124/jpet.107.125666
   Capasso R, 2005, GASTROENTEROLOGY, V129, P941, DOI 10.1053/j.gastro.2005.06.018
   Centonze D, 2007, BRAIN, V130, P2543, DOI 10.1093/brain/awm160
   Chang L, 2006, BRIT J PHARMACOL, V148, P102, DOI 10.1038/sj.bjp.0706699
   Chhatwal JP, 2005, NEUROPSYCHOPHARMACOL, V30, P516, DOI 10.1038/sj.npp.1300655
   Cohen C, 2005, NEUROPSYCHOPHARMACOL, V30, P145, DOI 10.1038/sj.npp.1300541
   Comelli F, 2007, BRIT J PHARMACOL, V152, P787, DOI 10.1038/sj.bjp.0707425
   Costa B, 2007, BRIT J PHARMACOL, V150, P535, DOI 10.1038/sj.bjp.0707139
   Costa B, 2005, PAIN, V116, P52, DOI 10.1016/j.pain.2005.03.043
   Costa B, 2006, BRIT J PHARMACOL, V148, P1022, DOI 10.1038/sj.bjp.0706798
   Cota D, 2007, DIABETES-METAB RES, V23, P507, DOI 10.1002/dmrr.764
   Croci T, 2007, BRIT J PHARMACOL, V150, P559, DOI 10.1038/sj.bjp.0707138
   Croci T, 2003, BRIT J PHARMACOL, V140, P115, DOI 10.1038/sj.bjp.0705412
   Cross-Mellor SK, 2007, PSYCHOPHARMACOLOGY, V190, P135, DOI 10.1007/s00213-006-0589-7
   Croxford JL, 2008, J NEUROIMMUNOL, V193, P120, DOI 10.1016/j.jneuroim.2007.10.024
   D'Argenio G, 2006, FASEB J, V20, P568, DOI 10.1096/fj.05-4943fje
   Darmani NA, 2005, NEUROPHARMACOLOGY, V49, P502, DOI 10.1016/j.neuropharm.2005.04.007
   de Lago E, 2004, EUR J PHARMACOL, V484, P249, DOI 10.1016/j.ejphar.2003.11.027
   de Lago E, 2006, EUR NEUROPSYCHOPHARM, V16, P7, DOI 10.1016/j.euroneuro.2005.06.001
   De Marchi Nicola, 2003, Lipids Health Dis, V2, P5, DOI 10.1186/1476-511X-2-5
   De Petrocellis L, 2000, FEBS LETT, V483, P52, DOI 10.1016/S0014-5793(00)02082-2
   De Vries TJ, 2001, NAT MED, V7, P1151, DOI 10.1038/nm1001-1151
   Degroot A, 2007, CURR OPIN PHARMACOL, V7, P62, DOI 10.1016/j.coph.2006.11.001
   Despres JP, 2005, NEW ENGL J MED, V353, P2121, DOI 10.1056/NEJMoa044537
   Di Marzo V, 2004, NAT REV DRUG DISCOV, V3, P771, DOI 10.1038/nrd1495
   Di Marzo V, 2006, GUT, V55, P1373, DOI 10.1136/gut.2005.090472
   Di Marzo V, 2001, NATURE, V410, P822, DOI 10.1038/35071088
   Di Marzo V, 2000, FASEB J, V14, P1432, DOI 10.1096/fj.14.10.1432
   Di Marzo V, 2007, CURR OPIN LIPIDOL, V18, P129, DOI 10.1097/MOL.0b013e32803dbdec
   Dickason-Chesterfield AK, 2006, CELL MOL NEUROBIOL, V26, P407, DOI 10.1007/s10571-006-9072-6
   Dinis P, 2004, J NEUROSCI, V24, P11253, DOI 10.1523/JNEUROSCI.2657-04.2004
   Domenicali M, 2005, GUT, V54, P522, DOI 10.1136/gut.2004.051599
   Esposito G, 2007, J PHARMACOL EXP THER, V322, P1144, DOI 10.1124/jpet.107.121566
   Evans RM, 2007, BRIT J PHARMACOL, V152, P404, DOI 10.1038/sj.bjp.0707411
   Fegley D, 2004, P NATL ACAD SCI USA, V101, P8756, DOI 10.1073/pnas.0400997101
   Fegley D, 2005, J PHARMACOL EXP THER, V313, P352, DOI 10.1124/jpet.104.078980
   Fernandez-Espejo E, 2005, NEUROBIOL DIS, V18, P591, DOI 10.1016/j.nbd.2004.10.015
   Fernandez-Espejo E, 2004, NEUROPSYCHOPHARMACOL, V29, P1134, DOI 10.1038/sj.npp.1300407
   Ferrer B, 2003, EUR J NEUROSCI, V18, P1607, DOI 10.1046/j.1460-9568.2003.02896.x
   Fong TM, 2007, J PHARMACOL EXP THER, V321, P1013, DOI 10.1124/jpet.106.118737
   Fowler CJ, 2003, J ENZYM INHIB MED CH, V18, P225, DOI 10.1080/1475636031000080216
   Gary-Bobo M, 2007, HEPATOLOGY, V46, P122, DOI 10.1002/hep.21641
   Gaskari SA, 2005, BRIT J PHARMACOL, V146, P315, DOI 10.1038/sj.bjp.0706331
   Gessa GL, 2005, ALCOHOL ALCOHOLISM, V40, P46, DOI 10.1093/alcalc/agh114
   Giuffrida A, 2004, NEUROPSYCHOPHARMACOL, V29, P2108, DOI 10.1038/sj.npp.1300558
   Gobbi G, 2005, P NATL ACAD SCI USA, V102, P18620, DOI 10.1073/pnas.0509591102
   González S, 2006, BRAIN RES, V1073, P209, DOI 10.1016/j.brainres.2005.12.014
   Griebel G, 2005, BIOL PSYCHIAT, V57, P261, DOI 10.1016/j.biopsych.2004.10.032
   Gubellini P, 2002, J NEUROSCI, V22, P6900
   Guindon J, 2007, BRIT J PHARMACOL, V150, P693, DOI 10.1038/sj.bjp.0706990
   Guzmán M, 2003, NAT REV CANCER, V3, P745, DOI 10.1038/nrc1188
   Hansson AC, 2007, NEUROPSYCHOPHARMACOL, V32, P117, DOI 10.1038/sj.npp.1301034
   Hanus L, 2003, BRAIN RES, V983, P144, DOI 10.1016/S0006-8993(03)03046-4
   Herling AW, 2007, AM J PHYSIOL-ENDOC M, V293, pE826, DOI 10.1152/ajpendo.00264.2007
   Hermann H, 2003, CELL MOL LIFE SCI, V60, P607, DOI 10.1007/s000180300052
   Hill MN, 2006, NEUROPSYCHOPHARMACOL, V31, P2591, DOI 10.1038/sj.npp.1301092
   Hill MN, 2006, EUR J NEUROSCI, V24, P1845, DOI 10.1111/j.1460-9568.2006.05061.x
   Hill MN, 2005, EUR NEUROPSYCHOPHARM, V15, P593, DOI 10.1016/j.euroneuro.2005.03.003
   Hillard CJ, 2007, J MOL NEUROSCI, V33, P18, DOI 10.1007/s12031-007-0045-0
   Högestätt ED, 2005, J BIOL CHEM, V280, P31405, DOI 10.1074/jbc.M501489200
   Hohmann AG, 2005, NATURE, V435, P1108, DOI 10.1038/nature03658
   Hohmann AG, 2006, AAPS J, V8, pE693, DOI 10.1208/aapsj080479
   Holt S, 2005, BRIT J PHARMACOL, V146, P467, DOI 10.1038/sj.bjp.0706348
   Horvath G, 2008, PAIN, V134, P277, DOI 10.1016/j.pain.2007.04.032
   Idris AI, 2005, NAT MED, V11, P774, DOI 10.1038/nm1255
   Iwamura H, 2001, J PHARMACOL EXP THER, V296, P420
   Izzo AA, 2008, J MOL MED, V86, P89, DOI 10.1007/s00109-007-0248-4
   Jamshidi N, 2001, BRIT J PHARMACOL, V134, P1151, DOI 10.1038/sj.bjp.0704379
   Janiak P, 2007, KIDNEY INT, V72, P1345, DOI 10.1038/sj.ki.5002540
   Jayamanne A, 2006, BRIT J PHARMACOL, V147, P281, DOI 10.1038/sj.bjp.0706510
   Jhaveri MD, 2007, BRIT J PHARMACOL, V152, P624, DOI 10.1038/sj.bjp.0707433
   Jhaveri MD, 2006, J NEUROSCI, V26, P13318, DOI 10.1523/JNEUROSCI.3326-06.2006
   Jonsson KO, 2003, ARCH TOXICOL, V77, P201, DOI 10.1007/s00204-002-0435-6
   Julien B, 2005, GASTROENTEROLOGY, V128, P742, DOI 10.1053/j.gastro.2004.12.050
   Kamprath K, 2006, J NEUROSCI, V26, P6677, DOI 10.1523/JNEUROSCI.0153-06.2006
   Karanian DA, 2005, J NEUROSCI, V25, P7813, DOI 10.1523/JNEUROSCI.2347-05.2005
   Karsak M, 2007, SCIENCE, V316, P1494, DOI 10.1126/science.1142265
   Kathuria S, 2003, NAT MED, V9, P76, DOI 10.1038/nm803
   Kelley BG, 2004, EUR J PHARMACOL, V496, P33, DOI 10.1016/j.ejphar.2004.06.011
   Kim K, 2006, EUR J PHARMACOL, V542, P100, DOI 10.1016/j.ejphar.2006.05.025
   Kirkham TC, 2002, BRIT J PHARMACOL, V136, P550, DOI 10.1038/sj.bjp.0704767
   Klein TW, 2005, NAT REV IMMUNOL, V5, P400, DOI 10.1038/nri1602
   Kreitzer AC, 2007, NATURE, V445, P643, DOI 10.1038/nature05506
   Kunos George, 2006, Nat Med, V12, P608, DOI 10.1038/nm0606-608
   La Rana G, 2006, J PHARMACOL EXP THER, V317, P1365, DOI 10.1124/jpet.105.100792
   Laine K, 2001, PHARMACEUT RES, V18, P494, DOI 10.1023/A:1011058411804
   Lambert DM, 2007, CHEMMEDCHEM, V2, P1701, DOI 10.1002/cmdc.200700168
   Lee J, 2006, NEUROPHARMACOLOGY, V51, P557, DOI 10.1016/j.neuropharm.2006.04.016
   Leung D, 2003, NAT BIOTECHNOL, V21, P687, DOI 10.1038/nbt826
   Lichtman AH, 2004, J PHARMACOL EXP THER, V311, P441, DOI 10.1124/jpet.104.069401
   Ligresti A, 2006, BRIT J PHARMACOL, V147, P83, DOI 10.1038/sj.bjp.0706418
   Ligresti A, 2004, BIOCHEM J, V380, P265, DOI 10.1042/BJ20031812
   Liu J, 2008, NEUROPHARMACOLOGY, V54, P1, DOI 10.1016/j.neuropharm.2007.05.020
   López-Rodríguez ML, 2003, EUR J MED CHEM, V38, P403, DOI 10.1016/S0223-5234(03)00045-X
   Lunn CA, 2006, J PHARMACOL EXP THER, V316, P780, DOI 10.1124/JPET.105.093500
   LUNN CA, 2007, BRIT J PHARMACOL, V153, P226
   Lutz B, 2007, MOL NEUROBIOL, V36, P92, DOI 10.1007/s12035-007-8004-x
   Maione S, 2006, J PHARMACOL EXP THER, V316, P969, DOI 10.1124/jpet.105.093286
   Maione S, 2007, BRIT J PHARMACOL, V150, P766, DOI 10.1038/sj.bjp.0707145
   Mallat A, 2007, EXPERT OPIN THER TAR, V11, P403, DOI 10.1517/14728222.11.3.403
   Maresz K, 2007, NAT MED, V13, P492, DOI 10.1038/nm1561
   Marsch R, 2007, J NEUROSCI, V27, P832, DOI 10.1523/JNEUROSCI.3303-06.2007
   Marsicano G, 2003, SCIENCE, V302, P84, DOI 10.1126/science.1088208
   Marsicano G, 2002, NATURE, V418, P530, DOI 10.1038/nature00839
   Massa F, 2004, J CLIN INVEST, V113, P1202, DOI 10.1172/JCI200419465
   Matias I, 2007, TRENDS ENDOCRIN MET, V18, P27, DOI 10.1016/j.tem.2006.11.006
   Matias I, 2006, J CLIN ENDOCR METAB, V91, P3171, DOI 10.1210/jc.2005-2679
   Mazzola C, 2003, EUR J PHARMACOL, V477, P219, DOI 10.1016/j.ejphar.2003.08.026
   Mechoulam R, 2002, PROSTAG LEUKOTR ESS, V66, P93, DOI 10.1054/plef.2001.0340
   Mendez-Sanchez N, 2007, LIVER INT, V27, P215, DOI 10.1111/j.1478-3231.2006.01401.x
   Mestre L, 2005, J NEUROCHEM, V92, P1327, DOI 10.1111/j.1471-4159.2004.02979.x
   MICALE V, 2007, SOC NEUR M PLANN WEB
   MILLER AM, 2007, BRIT J PHARMACOL, V153, P299
   Mitchell VA, 2007, CLIN EXP PHARMACOL P, V34, P1186, DOI 10.1111/j.1440-1681.2007.04692.x
   Mitrirattanakul S, 2006, PAIN, V126, P102, DOI 10.1016/j.pain.2006.06.016
   Moezi L, 2006, BRIT J PHARMACOL, V149, P898, DOI 10.1038/sj.bjp.0706928
   Monory K, 2006, NEURON, V51, P455, DOI 10.1016/j.neuron.2006.07.006
   Monteleone P, 2005, NEUROPSYCHOPHARMACOL, V30, P1216, DOI 10.1038/sj.npp.1300695
   Moore SA, 2005, P NATL ACAD SCI USA, V102, P17852, DOI 10.1073/pnas.0507470102
   Moreira FA, 2008, NEUROPHARMACOLOGY, V54, P141, DOI 10.1016/j.neuropharm.2007.07.005
   Morgese MG, 2007, EXP NEUROL, V208, P110, DOI 10.1016/j.expneurol.2007.07.021
   Naidu PS, 2007, PSYCHOPHARMACOLOGY, V192, P61, DOI 10.1007/s00213-006-0689-4
   Niforatos W, 2007, MOL PHARMACOL, V71, P1209, DOI 10.1124/mol.106.033621
   Nucci C, 2007, INVEST OPHTH VIS SCI, V48, P2997, DOI 10.1167/iovs.06-1355
   O'Sullivan SE, 2007, BRIT J PHARMACOL, V152, P576, DOI 10.1038/sj.bjp.0707423
   Ofek O, 2006, P NATL ACAD SCI USA, V103, P696, DOI 10.1073/pnas.0504187103
   Oka S, 2005, J BIOL CHEM, V280, P18488, DOI 10.1074/jbc.M413260200
   Oka S, 2007, BIOCHEM BIOPH RES CO, V362, P928, DOI 10.1016/j.bbrc.2007.08.078
   Oka S, 2006, J IMMUNOL, V177, P8796, DOI 10.4049/jimmunol.177.12.8796
   Orliac ML, 2003, J PHARMACOL EXP THER, V304, P179, DOI 10.1124/jpet.102.041095
   Ortar G, 2003, BIOCHEM PHARMACOL, V65, P1473, DOI 10.1016/S0006-2952(03)00109-6
   Ortar G, 2008, EUR J MED CHEM, V43, P62, DOI 10.1016/j.ejmech.2007.02.023
   Osei-Hyiaman D, 2005, J CLIN INVEST, V115, P1298, DOI 10.1172/JCI200523057
   Oz M, 2006, CURR PHARM DESIGN, V12, P227, DOI 10.2174/138161206775193073
   Pacher P, 2006, PHARMACOL REV, V58, P389, DOI 10.1124/pr.58.3.2
   Pagano C, 2007, J CLIN ENDOCR METAB, V92, P4810, DOI 10.1210/jc.2007-0768
   Patel S, 2004, ENDOCRINOLOGY, V145, P5431, DOI 10.1210/en.2004-0638
   Patel S, 2006, J PHARMACOL EXP THER, V318, P304, DOI 10.1124/jpet.106.101287
   Pertwee RG, 2006, BRIT J PHARMACOL, V147, pS163, DOI 10.1038/sj.bjp.0706406
   Petrosino S, 2007, NEUROPHARMACOLOGY, V52, P415, DOI 10.1016/j.neuropharm.2006.08.011
   Pi-Sunyer F, 2006, JAMA-J AM MED ASSOC, V295, P761, DOI 10.1001/jama.295.7.761
   Piomelli D, 2006, CNS DRUG REV, V12, P21, DOI 10.1111/j.1527-3458.2006.00021.x
   Piomelli Daniele, 2005, Curr Opin Investig Drugs, V6, P672
   Poirier B, 2005, DIABETES OBES METAB, V7, P65, DOI 10.1111/j.1463-1326.2004.00374.x
   Rademacher DJ, 2008, NEUROPHARMACOLOGY, V54, P108, DOI 10.1016/j.neuropharm.2007.06.012
   Ramírez BG, 2005, J NEUROSCI, V25, P1904, DOI 10.1523/JNEUROSCI.4540-04.2005
   Rinaldi-Carmona M, 2004, J PHARMACOL EXP THER, V310, P905, DOI 10.1124/jpet.104.067884
   Rinaldi-Carmona M, 1998, J PHARMACOL EXP THER, V284, P644
   Ronesi J, 2004, J NEUROSCI, V24, P1673, DOI 10.1523/JNEUROSCI.5214-03.2004
   Rouzer CA, 2008, J BIOL CHEM, V283, P8065, DOI 10.1074/jbc.R800005200
   Rubino T, 2008, CEREB CORTEX, V18, P1292, DOI 10.1093/cercor/bhm161
   Russo E, 2006, MED HYPOTHESES, V66, P234, DOI 10.1016/j.mehy.2005.08.026
   Russo R, 2007, J PHARMACOL EXP THER, V322, P236, DOI 10.1124/jpet.107.119941
   Ryberg E, 2007, BRIT J PHARMACOL, V152, P1092, DOI 10.1038/sj.bjp.0707460
   Saario SM, 2005, CHEM BIOL, V12, P649, DOI 10.1016/j.chembiol.2005.04.013
   Sáez-Cassanelli JL, 2007, J NEUROCHEM, V103, P2629, DOI 10.1111/j.1471-4159.2007.05000.x
   Sarnataro D, 2006, MOL PHARMACOL, V70, P1298, DOI 10.1124/mol.106.025601
   Scheen AJ, 2006, LANCET, V368, P1660, DOI 10.1016/S0140-6736(06)69571-8
   Sharkey KA, 2007, EUR J NEUROSCI, V25, P2773, DOI 10.1111/j.1460-9568.2007.05521.x
   Shoemaker JL, 2007, J NEUROCHEM, V101, P87, DOI 10.1111/j.1471-4159.2006.04346.x
   Sit SY, 2007, BIOORG MED CHEM LETT, V17, P3287, DOI 10.1016/j.bmcl.2007.04.009
   Solinas M, 2005, NEUROPSYCHOPHARMACOL, V30, P2046, DOI 10.1038/sj.npp.1300754
   Solinas M, 2007, J PHARMACOL EXP THER, V321, P370, DOI 10.1124/jpet.106.114124
   Solinas M, 2006, J NEUROCHEM, V98, P408, DOI 10.1111/j.1471-4159.2006.03880.x
   SOTRR MA, 2007, CURR OPIN PHARMACOL, V7, P575
   Spano MS, 2004, BRIT J PHARMACOL, V143, P343, DOI 10.1038/sj.bjp.0705932
   Starowicz K, 2007, PHARMACOL THERAPEUT, V114, P13, DOI 10.1016/j.pharmthera.2007.01.005
   STEINER MA, 2007, PHARMACOGENOMIC 0807, DOI DOI 10.1038/SJ.TPJ.6500466
   Steiner MA, 2008, PSYCHONEUROENDOCRINO, V33, P54, DOI 10.1016/j.psyneuen.2007.09.008
   Suplita RL, 2005, NEUROPHARMACOLOGY, V49, P1201, DOI 10.1016/j.neuropharm.2005.07.007
   Tahim AS, 2005, NEUROSCIENCE, V136, P539, DOI 10.1016/j.neuroscience.2005.08.005
   Teixeira-Clerc F, 2006, NAT MED, V12, P671, DOI 10.1038/nm1421
   Tzavara ET, 2006, BIOL PSYCHIAT, V59, P508, DOI 10.1016/j.biopsych.2005.08.019
   Ueda Y, 2005, EUR J PHARMACOL, V520, P164, DOI 10.1016/j.ejphar.2005.08.013
   Van der Stelt M, 2006, CELL MOL LIFE SCI, V63, P1410, DOI 10.1007/s00018-006-6037-3
   van der Stelt M, 2005, FASEB J, V19, P1140, DOI 10.1096/fj.04-3010fje
   Van Gaal LF, 2005, LANCET, V365, P1389, DOI 10.1016/S0140-6736(05)66374-X
   Van Gaal L, 2008, DIABETES CARE, V31, pS229, DOI 10.2337/dc08-s258
   Vandevoorde S, 2007, BRIT J PHARMACOL, V150, P186, DOI 10.1038/sj.bjp.0706971
   Vinod KY, 2008, J NEUROCHEM, V104, P233, DOI 10.1111/j.1471-4159.2007.04956.x
   Vlachou S, 2006, PSYCHOPHARMACOLOGY, V188, P293, DOI 10.1007/s00213-006-0506-0
   Wettschureck N, 2006, MOL CELL BIOL, V26, P5888, DOI 10.1128/MCB.00397-06
   Witting A, 2006, P NATL ACAD SCI USA, V103, P6362, DOI 10.1073/pnas.0510418103
   Woodward DF, 2008, BRIT J PHARMACOL, V153, P410, DOI 10.1038/sj.bjp.0707434
   Zhang D, 2007, NEUROPHARMACOLOGY, V52, P1095, DOI 10.1016/j.neuropharm.2006.11.009
   Zygmunt PM, 2000, EUR J PHARMACOL, V396, P39, DOI 10.1016/S0014-2999(00)00207-7
NR 211
TC 663
Z9 722
U1 2
U2 89
PU NATURE RESEARCH
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 1474-1776
EI 1474-1784
J9 NAT REV DRUG DISCOV
JI Nat. Rev. Drug Discov.
PD MAY
PY 2008
VL 7
IS 5
BP 438
EP 455
DI 10.1038/nrd2553
PG 18
WC Biotechnology & Applied Microbiology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Pharmacology & Pharmacy
GA 294QF
UT WOS:000255419900017
PM 18446159
DA 2025-06-11
ER

PT J
AU Diaz, A
   Muñoz-Arenas, G
   Caporal-Hernandez, K
   Vazquez-Roque, R
   Lopez-Lopez, G
   Kozina, A
   Espinosa, B
   Flores, G
   Treviño, S
   Guevara, J
AF Diaz, Alfonso
   Munoz-Arenas, Guadalupe
   Caporal-Hernandez, Karen
   Vazquez-Roque, Ruben
   Lopez-Lopez, Gustavo
   Kozina, Anna
   Espinosa, Blanca
   Flores, Gonzalo
   Trevino, Samuel
   Guevara, Jorge
TI Gallic acid improves recognition memory and decreases
   oxidative-inflammatory damage in the rat hippocampus with metabolic
   syndrome
SO SYNAPSE
LA English
DT Article
DE dendritic spines; Golgi-Cox stain; interleukins; novel objects;
   polyphenols; reactive oxygen species
ID STRESS; STREPTOZOTOCIN; GLUCOSE; NEUROTROPHINS; ASSOCIATION;
   IMPAIRMENTS; ACTIVATION; PLASTICITY; EXPOSURE; DEFICITS
AB Metabolic syndrome (MS) results from excessive consumption of high-calorie foods and sedentary lifestyles. Clinically, insulin resistance, abdominal obesity, hyperglycemia, dyslipidemia, and hypertension are observed. MS has been considered a risk factor in the development of dementia. In the brain, a metabolically impaired environment generates oxidative stress and excessive production of pro-inflammatory cytokines that deteriorate the morphology and neuronal function in the hippocampus, leading to cognitive impairment. Therapeutic alternatives suggest that phenolic compounds can be part of the treatment for neuropathies and metabolic diseases. In recent years, the use of Gallic Acid (GA) has demonstrated antioxidant and anti-inflammatory effects that contribute to neuroprotection and memory improvement in animal models. However, the effect of GA on hippocampal neurodegeneration and memory impairment under MS conditions is still unclear. In this work, we administered GA (20 mg/kg) for 60 days to rats with MS. The results show that GA treatment improved zoometric and biochemical parameters, as well as the recognition memory, in animals with MS. Additionally, GA administration increased hippocampal dendritic spines and decreased oxidative stress and inflammation. Our results show that GA treatment improves metabolism: reducing the oxidative and inflammatory environment that facilitates the recovery of the neuronal morphology in the hippocampus of rats with MS. Consequently, the recognition of objects by these animals, suggesting that GA could be used therapeutically in metabolic disorders that cause dementia.
C1 [Diaz, Alfonso; Munoz-Arenas, Guadalupe; Caporal-Hernandez, Karen; Lopez-Lopez, Gustavo; Trevino, Samuel] Benemerita Univ Autonoma Puebla, Fac Ciencias Quim, Puebla, Mexico.
   [Vazquez-Roque, Ruben; Flores, Gonzalo] Benemerita Univ Autonoma Puebla, Inst Fisiol, Lab Neuropsiquiatria, Puebla, Mexico.
   [Kozina, Anna] Univ Nacl Autonoma Mexico, Inst Quim, Ciudad De Mexico, Mexico.
   [Espinosa, Blanca] ICV, Dept Bioquim, Inst Nacl Enfermedades Resp, Ciudad De Mexico, Mexico.
   [Guevara, Jorge] Univ Nacl Autonoma Mexico, Fac Med, Dept Bioquim, Ciudad De Mexico, Mexico.
C3 Benemerita Universidad Autonoma de Puebla; Benemerita Universidad
   Autonoma de Puebla; Universidad Nacional Autonoma de Mexico; Universidad
   Nacional Autonoma de Mexico
RP Guevara, J (corresponding author), Univ Nacl Autonoma Mexico, Fac Med, Dept Bioquim, Ciudad De Mexico, Mexico.
EM jorge.guevara@comunidad.unam.mx
RI Vazquez Roque, Ruben/L-5757-2013; Flores, Gonzalo/B-1807-2014
OI Guevara, Jorge/0000-0003-3428-3179; Diaz, Alfonso/0000-0003-4092-6636;
   Flores, Gonzalo/0000-0002-4100-2104; Munoz-Arenas,
   Guadalupe/0000-0002-7622-5308; Vazquez Roque, Ruben/0000-0002-2712-5714;
   Kozina, Anna/0000-0002-4287-2953
FU VIEP-BUAP grant [DIFA-NAT18-G, TEMS-NAT18-I]; PAPIIT-UNAM [IN214117]
FX Funding for this study was provided by grants from VIEP-BUAP grant (No.
   DIFA-NAT18-G) to AD, (No. TEMS-NAT18-I) to ST and PAPIIT-UNAM (IN214117)
   to GJ. None of the funding institutions had any further role in the
   study design, the collection of data, analyses, and interpretation of
   data, writing of the report or in the interpretation of data, and the
   decision to submit the paper for publication
CR Abdel-Moneim A, 2017, METAB BRAIN DIS, V32, P1279, DOI 10.1007/s11011-017-0039-8
   Fernandes FHA, 2016, CRIT REV ANAL CHEM, V46, P257, DOI 10.1080/10408347.2015.1095064
   Alvarez-Nölting R, 2012, NEUROCHEM RES, V37, P105, DOI 10.1007/s11064-011-0588-x
   Antunes M, 2012, COGN PROCESS, V13, P93, DOI 10.1007/s10339-011-0430-z
   Atti AR, 2019, AM J GERIAT PSYCHIAT, V27, P625, DOI 10.1016/j.jagp.2019.01.214
   Bahadoran Z, 2013, J HUM NUTR DIET, V26, P145, DOI 10.1111/jhn.12048
   Bak EJ, 2013, SCAND J CLIN LAB INV, V73, P607, DOI 10.3109/00365513.2013.831470
   Bhullar KS, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/891748
   Biessels GJ, 2002, EUR J PHARMACOL, V441, P1, DOI 10.1016/S0014-2999(02)01486-3
   Borshchev YY, 2019, LIFE SCI, V237, DOI 10.1016/j.lfs.2019.116932
   Bouayed J, 2009, J MED FOOD, V12, P861, DOI 10.1089/jmf.2008.0165
   BRUNK SD, 1981, CLIN CHEM, V27, P924
   Cacabelos R, 2016, CNS NEUROL DISORD-DR, V15, P141, DOI 10.2174/1871527315666160202121548
   Can ÖD, 2017, LIFE SCI, V190, P110, DOI 10.1016/j.lfs.2017.09.023
   Chao J, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0096969
   Chatzigeorgiou A, 2009, IN VIVO, V23, P245
   Choi KC, 2009, MOL CANCER RES, V7, P2011, DOI 10.1158/1541-7786.MCR-09-0239
   Nery-Flores SD, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/9620684
   Diaz A, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/1358057
   Dludla PV, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010023
   DUGAN LL, 1995, J NEUROSCI, V15, P6377
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Farbood Y, 2015, LIFE SCI, V124, P120, DOI 10.1016/j.lfs.2015.01.013
   Farbood Y, 2013, AVICENNA J PHYTOMEDI, V3, P329
   Flores G, 2005, NEUROSCIENCE, V133, P463, DOI 10.1016/j.neuroscience.2005.02.021
   Flores G, 1996, J NEUROSCI, V16, P2020
   Gandhi GR, 2014, EUR J PHARMACOL, V745, P201, DOI 10.1016/j.ejphar.2014.10.044
   Gasparova Z, 2018, GEN PHYSIOL BIOPHYS, V37, P619, DOI 10.4149/gpb_2018016
   Gibb R, 1998, J NEUROSCI METH, V79, P1, DOI 10.1016/S0165-0270(97)00163-5
   Gibon J, 2017, NEUROSCIENTIST, V23, P587, DOI 10.1177/1073858417697037
   Giudetti AM, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/3416028
   Gomes JAS, 2020, J NUTR BIOCHEM, V77, DOI 10.1016/j.jnutbio.2019.108317
   Habschied K, 2020, FOODS, V9, DOI 10.3390/foods9020238
   Hsu CL, 2007, BRIT J NUTR, V98, P727, DOI 10.1017/S000711450774686X
   Hurrle S, 2017, BIOMED J, V40, P257, DOI 10.1016/j.bj.2017.06.007
   Ivanova N, 2020, J NEUROINFLAMM, V17, DOI 10.1186/s12974-020-1698-7
   Jha SK, 2017, BBA-MOL BASIS DIS, V1863, P1132, DOI 10.1016/j.bbadis.2016.06.015
   Kade Ige Joseph, 2014, Journal of Basic and Clinical Physiology and Pharmacology, V25, P35, DOI 10.1515/jbcpp-2012-0062
   Kahkeshani N, 2019, IRAN J BASIC MED SCI, V22, P225, DOI 10.22038/ijbms.2019.32806.7897
   Kanazawa LKS, 2016, FREE RADICAL BIO MED, V99, P79, DOI 10.1016/j.freeradbiomed.2016.07.027
   Kannan MM, 2011, EUR J PHARMACOL, V659, P45, DOI 10.1016/j.ejphar.2011.02.037
   Karimi G, 2020, NUTR METAB CARDIOVAS, V30, P717, DOI 10.1016/j.numecd.2020.02.001
   KIESOW LA, 1972, CLIN CHIM ACTA, V41, P123, DOI 10.1016/0009-8981(72)90503-7
   Kolb B, 1998, NEUROSCI BIOBEHAV R, V22, P143, DOI 10.1016/S0149-7634(97)00008-0
   Latha RCR, 2011, CHEM-BIOL INTERACT, V189, P112, DOI 10.1016/j.cbi.2010.11.005
   Lee JE, 2020, J CLIN MED, V9, DOI 10.3390/jcm9010122
   Li S., 2021, NAT MED, V306, DOI [DOI 10.1038/s41591-020-0897-1, 10.1002/mame.202100070]
   Liu X, 2020, CLIN BIOCHEM, V82, P40, DOI 10.1016/j.clinbiochem.2020.03.007
   Mansouri MT, 2013, PHARMACOL BIOCHEM BE, V111, P90, DOI 10.1016/j.pbb.2013.09.002
   Maya S, 2018, NEUROCHEM INT, V121, P50, DOI 10.1016/j.neuint.2018.10.011
   McDaid DG, 2005, BEHAV PHARMACOL, V16, P237, DOI 10.1097/01.fbp.0000166465.75809.85
   Misiak B, 2012, BRAIN RES BULL, V89, P144, DOI 10.1016/j.brainresbull.2012.08.003
   Moreno-Valdespino CA, 2020, FOOD RES INT, V130, DOI 10.1016/j.foodres.2019.108905
   Morgan T. E., 2007, V35, P83
   Moyse E, 2019, MECH AGEING DEV, V179, P51, DOI 10.1016/j.mad.2019.01.002
   Munoz-Arenas G, 2020, SYNAPSE, V74, DOI 10.1002/syn.22153
   Nazir N, 2007, J ETHNOPHARMACOL, V112, P401, DOI 10.1016/j.jep.2007.02.023
   Novelli Michela, 2007, Pancreas, V35, pe10
   Olmo-Cunillera A, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010054
   Oron-Herman M, 2008, AM J HYPERTENS, V21, P1018, DOI 10.1038/ajh.2008.218
   Paxinos G, 1998, RAT BRAIN IN STEREOTAXIC COORDINATES, FOURTH ED., pix
   Pereira MM, 2018, METAB BRAIN DIS, V33, P1573, DOI 10.1007/s11011-018-0264-9
   Pugazhenthi S, 2017, PROG MOL BIOL TRANSL, V146, P243, DOI 10.1016/bs.pmbts.2016.12.016
   Pugazhenthi S, 2017, BBA-MOL BASIS DIS, V1863, P1037, DOI 10.1016/j.bbadis.2016.04.017
   Raven F, 2021, EUR J NEUROSCI, V54, P6972, DOI 10.1111/ejn.14684
   Rawlings AM, 2019, DIABETES CARE, V42, P1248, DOI 10.2337/dc19-0120
   Rivera DS, 2018, MOL NEUROBIOL, V55, P9169, DOI 10.1007/s12035-018-0969-0
   Rojas-Gutierrez E, 2017, SYNAPSE, V71, DOI 10.1002/syn.21990
   Saibabu V, 2015, ADV PHARMACOL SCI, V2015, DOI 10.1155/2015/823539
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Samad N, 2019, METAB BRAIN DIS, V34, P1091, DOI 10.1007/s11011-019-00432-1
   Schimites PI, 2020, NEUROSCI LETT, V714, DOI 10.1016/j.neulet.2019.134560
   Setayesh T, 2019, EUR J NUTR, V58, P2315, DOI 10.1007/s00394-018-1782-2
   Shaik AH, 2012, J ETHNOPHARMACOL, V141, P33, DOI 10.1016/j.jep.2012.01.011
   Shinohara M, 2019, ADV EXP MED BIOL, V1128, P85, DOI 10.1007/978-981-13-3540-2_5
   SHOLL DA, 1953, J ANAT, V87, P387
   Singh RB, 2012, CAN J PHYSIOL PHARM, V90, P1171, DOI [10.1139/Y2012-122, 10.1139/y2012-122]
   Thyagaraju BM, 2008, ZOOL SCI, V25, P854, DOI 10.2108/zsj.25.854
   Treviño S, 2017, J CHEM NEUROANAT, V82, P65, DOI 10.1016/j.jchemneu.2017.02.007
   Treviño S, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/6058705
   Treviño S, 2015, SYNAPSE, V69, P421, DOI 10.1002/syn.21832
   Treviño S, 2015, J INORG BIOCHEM, V147, P85, DOI 10.1016/j.jinorgbio.2015.04.002
   Valcarcel-Ares MN, 2019, J GERONTOL A-BIOL, V74, P290, DOI 10.1093/gerona/gly127
   Variya BC, 2020, PHYTOMEDICINE, V73, DOI 10.1016/j.phymed.2019.152906
   Vidal B, 2017, SYNAPSE, V71, DOI 10.1002/syn.21952
   Zelikoff JT, 2018, TOXICOL SCI, V162, P276, DOI 10.1093/toxsci/kfx257
   Zhu JX, 2019, METAB BRAIN DIS, V34, P93, DOI 10.1007/s11011-018-0328-x
NR 87
TC 34
Z9 35
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0887-4476
EI 1098-2396
J9 SYNAPSE
JI Synapse
PD FEB
PY 2021
VL 75
IS 2
AR e22186
DI 10.1002/syn.22186
EA SEP 2020
PG 17
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA PC9OG
UT WOS:000564511200001
PM 32780904
DA 2025-06-11
ER

PT J
AU Miller, KG
   Gianaros, PJ
   Kamarck, TW
   Anderson, BA
   Muldoon, MF
   Manuck, SB
AF Miller, Karissa G.
   Gianaros, Peter J.
   Kamarck, Thomas W.
   Anderson, Barbara A.
   Muldoon, Matthew F.
   Manuck, Stephen B.
TI Cortisol activity partially accounts for a relationship between
   community socioeconomic position and atherosclerosis
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Cortisol; HPA; Community socioeconomic position; SES; Atherosclerosis;
   IMT
ID INTIMA-MEDIA THICKNESS; CORONARY-ARTERY-DISEASE; DIURNAL CORTISOL;
   METABOLIC SYNDROME; SALIVARY CORTISOL; NEIGHBORHOOD DISADVANTAGE;
   HEART-DISEASE; ASSOCIATION; STRESS; RISK
AB Compared to others, individuals living in communities of socioeconomic disadvantage experience more atherosclerotic cardiovascular disease (CVD) and a greater extent of preclinical atherosclerosis. Although the mechanisms underlying these associations remain unclear, it is widely hypothesized that alterations in normative cortisol release from the Hypothalamic Pituitary Adrenal (HPA) axis may play a role in linking lower community socioeconomic position (C-SEP) to CVD risk. The current study examined this hypothesis in relation to a marker of preclinical atherosclerosis among 488 healthy midlife adults (30-54 years, Mean age= 43, 52% Female, 81% White). All participants were employed and without clinical CVD. C-SEP was estimated from census tract data, and atherosclerosis was measured as intima-medial thickness of the carotid arteries (cIMT) by duplex ultrasonography. Four indicators of HPA activity [cortisol at awakening and the cortisol awakening response (CAR), rate of diurnal decline in cortisol (diurnal slope), and total output expressed as area under the curve (AUC)] were derived from salivary cortisol measurements obtained from 5 samples on each of 3 working days. Path analyses were used to examine associations of C-SEP with cIMT and HPA activity and to test whether individual differences in HPA activity could account for any association of C-SEP with cIMT using bootstrapping (5000 iterations). All models were adjusted for age, sex, race, and composite measures of both individual-level socioeconomic position (income, education, occupation), and cardiometabolic risk (systolic and diastolic blood pressure, waist circumference, fasting lipids and glucose). Lower C-SEP was related to both greater cIMT (b = -0.004, p = .021) and a flatter diurnal slope of cortisol (b = -0.001, p = .039). An indirect effect showed attenuated diurnal slope to partially mediate the relationship between C-SEP and cIMT (95% CI = -0.0018 to -0.0001), and a residual direct effect of C-SEP on cIMT remained significant (95% CI = -0.0097 to -0.004). These results suggest that low C-SEP associations with preclinical atherosclerosis may be due in part to correlated variation in adrenocortical activity.
C1 [Miller, Karissa G.] Calif State Univ Long Beach, Dept Psychol, 1250 Bellflower Blvd, Long Beach, CA 90808 USA.
   [Gianaros, Peter J.; Kamarck, Thomas W.; Anderson, Barbara A.; Manuck, Stephen B.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA.
   [Muldoon, Matthew F.] Univ Pittsburgh, Sch Med, Div Cardiol, Pittsburgh, PA 15261 USA.
C3 California State University System; California State University Long
   Beach; Pennsylvania Commonwealth System of Higher Education (PCSHE);
   University of Pittsburgh; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh
RP Miller, KG (corresponding author), Calif State Univ Long Beach, Dept Psychol, 1250 Bellflower Blvd, Long Beach, CA 90808 USA.
EM karissa.miller@csulb.edu; gianaros@pitt.edu; tkam@pitt.edu;
   baa1@pitt.edu; mfm10@pitt.edu; manuck@pitt.edu
FU NIH [P01 HL040962, RO1 AG056043]; National Heart Lung and Blood
   Institute [P01HL040962] Funding Source: NIH RePORTER
FX We wish to acknowledge the collaboration of Dr. Clemens Kirschbaum in
   the analysis of salivary cortisol samples collected for this studyThis
   research was supported by NIH Grant P01 HL040962 and RO1 AG056043.
CR Abraham SB, 2013, OBESITY, V21, pE105, DOI 10.1002/oby.20083
   Adam EK, 2017, PSYCHONEUROENDOCRINO, V83, P25, DOI 10.1016/j.psyneuen.2017.05.018
   Agarwal S, 2012, CARDIOL RES PRACT, V2012, DOI 10.1155/2012/919425
   Akaza I, 2010, ENDOCR J, V57, P245, DOI 10.1507/endocrj.K09E-260
   Alevizaki M, 2007, METABOLISM, V56, P222, DOI 10.1016/j.metabol.2006.09.017
   Anagnostis P, 2009, J CLIN ENDOCR METAB, V94, P2692, DOI 10.1210/jc.2009-0370
   Brenner AB, 2013, J YOUTH ADOLESCENCE, V42, P792, DOI 10.1007/s10964-012-9838-8
   Carson AP, 2007, ANN EPIDEMIOL, V17, P296, DOI 10.1016/j.annepidem.2006.07.009
   Chaix B, 2009, ANNU REV PUBL HEALTH, V30, P81, DOI 10.1146/annurev.publhealth.031308.100158
   Chen E, 2006, HEALTH PSYCHOL, V25, P704, DOI 10.1037/0278-6133.25.6.704
   Clow A, 2010, NEUROSCI BIOBEHAV R, V35, P97, DOI 10.1016/j.neubiorev.2009.12.011
   de Mestral C, 2017, CURR CARDIOL REP, V19, DOI 10.1007/s11886-017-0917-z
   Dekker MJHJ, 2008, J CLIN ENDOCR METAB, V93, P3741, DOI 10.1210/jc.2008-0496
   Do DP, 2011, HEALTH PLACE, V17, P625, DOI 10.1016/j.healthplace.2010.12.019
   Dochat C, 2020, PSYCHOSOM MED, V82, pA3, DOI 10.1097/PSY.0000000000000825
   Dowd JB, 2009, INT J EPIDEMIOL, V38, P1297, DOI 10.1093/ije/dyp277
   Eller NH, 2005, PSYCHONEUROENDOCRINO, V30, P715, DOI 10.1016/j.psyneuen.2005.01.005
   Eller NH, 2001, ATHEROSCLEROSIS, V159, P175, DOI 10.1016/S0021-9150(01)00487-7
   Finegood ED, 2017, DEV PSYCHOPATHOL, V29, P1649, DOI 10.1017/S0954579417001304
   Foraker RE, 2019, GLOB HEART, V14, P241, DOI 10.1016/j.gheart.2019.04.007
   Foraker RE, 2011, ANN EPIDEMIOL, V21, P580, DOI 10.1016/j.annepidem.2011.03.004
   Fries E, 2009, INT J PSYCHOPHYSIOL, V72, P67, DOI 10.1016/j.ijpsycho.2008.03.014
   Garcez A, 2018, PSYCHONEUROENDOCRINO, V95, P50, DOI 10.1016/j.psyneuen.2018.05.023
   Gianaros PJ, 2017, CEREB CORTEX, V27, P460, DOI 10.1093/cercor/bhv233
   Gianaros PJ, 2013, CEREB CORTEX, V23, P2058, DOI 10.1093/cercor/bhs191
   Hajat A, 2015, HEALTH PLACE, V34, P199, DOI 10.1016/j.healthplace.2015.05.017
   Hajat A, 2013, PSYCHONEUROENDOCRINO, V38, P1036, DOI 10.1016/j.psyneuen.2012.10.007
   Hajat A, 2010, PSYCHONEUROENDOCRINO, V35, P932, DOI 10.1016/j.psyneuen.2009.12.009
   Hayes A.F., 2013, The PROCESS macro for SPSS and SAS
   Hollingshead August, 2011, Yale Journal of Sociology, V8, P21
   Jennings JR, 2013, STROKE, V44, P2480, DOI 10.1161/STROKEAHA.113.001716
   John-Henderson NA, 2016, PSYCHOSOM MED, V78, P319, DOI 10.1097/PSY.0000000000000259
   Joseph NT, 2014, PSYCHOSOM MED, V76, P347, DOI 10.1097/PSY.0000000000000071
   Karb RA, 2012, SOC SCI MED, V75, P1038, DOI 10.1016/j.socscimed.2012.03.031
   Koertge J, 2002, PSYCHONEUROENDOCRINO, V27, P893, DOI 10.1016/S0306-4530(02)00002-1
   Kraemer HC, 2006, AM J GERIAT PSYCHIAT, V14, P325, DOI 10.1097/01.JGP.0000201816.26786.5b
   Lorenz MW, 2007, CIRCULATION, V115, P459, DOI 10.1161/CIRCULATIONAHA.106.628875
   Lorenzatti AJ, 2019, CURR OPIN CARDIOL, V34, P418, DOI 10.1097/HCO.0000000000000625
   Malanchini M, 2021, MOL PSYCHIATR, V26, P4823, DOI 10.1038/s41380-020-0747-z
   Matthews K, 2006, PSYCHOSOM MED, V68, P657, DOI 10.1097/01.psy.0000244071.42939.0e
   Miller GE, 2007, PSYCHOL BULL, V133, P25, DOI 10.1037/0033-2909.133.1.25
   Miller KG, 2016, PSYCHONEUROENDOCRINO, V68, P177, DOI 10.1016/j.psyneuen.2016.03.004
   Murray ET, 2010, AM J EPIDEMIOL, V171, P1099, DOI 10.1093/aje/kwq044
   Neary NM, 2013, J CLIN ENDOCR METAB, V98, P2045, DOI 10.1210/jc.2012-3754
   Nordstrom CK, 2004, SOC SCI MED, V59, P2139, DOI 10.1016/j.socscimed.2004.03.017
   Peppa-Patrikiou M, 1998, DIABETES CARE, V21, P1004, DOI 10.2337/diacare.21.6.1004
   Petersen KL, 2006, AM J HYPERTENS, V19, P560, DOI 10.1016/j.amjhyper.2005.12.008
   Peterson LM, 2017, HEALTH PSYCHOL, V36, P502, DOI 10.1037/hea0000468
   Pruessner JC, 2003, PSYCHONEUROENDOCRINO, V28, P916, DOI 10.1016/S0306-4530(02)00108-7
   Ranjit N, 2006, ARTERIOSCL THROM VAS, V26, P411, DOI 10.1161/01.ATV.0000198245.16342.3d
   Reynolds RM, 2009, QJM-INT J MED, V102, P469, DOI 10.1093/qjmed/hcp057
   Roe JJ, 2013, INT J ENV RES PUB HE, V10, P4086, DOI 10.3390/ijerph10094086
   Roubinov DS, 2018, PSYCHOSOM MED, V80, P492, DOI [10.1097/PSY.0000000000000585, 10.1097/psy.0000000000000585]
   Roux AVD, 2016, GLOB HEART, V11, P353, DOI 10.1016/j.gheart.2016.08.002
   Roux AVD, 2001, AM J PUBLIC HEALTH, V91, P1783, DOI 10.2105/AJPH.91.11.1783
   Rudolph KE, 2014, HEALTH PLACE, V25, P68, DOI 10.1016/j.healthplace.2013.11.001
   Silverman MN, 2012, ANN NY ACAD SCI, V1261, P55, DOI 10.1111/j.1749-6632.2012.06633.x
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Soriano-Rodríguez P, 2010, PEDIATR RES, V68, P452, DOI 10.1203/PDR.0b013e3181efc310
   Topel ML, 2019, AM J CARDIOL, V123, P284, DOI 10.1016/j.amjcard.2018.10.011
   Whitworth Judith A, 2005, Vasc Health Risk Manag, V1, P291, DOI 10.2147/vhrm.2005.1.4.291
   Wu MY, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18102034
NR 62
TC 3
Z9 3
U1 0
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD SEP
PY 2021
VL 131
AR 105292
DI 10.1016/j.psyneuen.2021.105292
EA JUN 2021
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA UJ3YJ
UT WOS:000691224600018
PM 34144404
OA hybrid
DA 2025-06-11
ER

PT J
AU Marycz, K
   Michalak, I
   Kocherova, I
   Maredziak, M
   Weiss, C
AF Marycz, Krzysztof
   Michalak, Izabela
   Kocherova, Ievgeniia
   Maredziak, Monika
   Weiss, Christine
TI The Cladophora glomerata Enriched by Biosorption Process in
   Cr(III) Improves Viability, and Reduces Oxidative Stress and Apoptosis
   in Equine Metabolic Syndrome Derived Adipose Mesenchymal Stromal Stem
   Cells (ASCs) and Their Extracellular Vesicles (MV's)
SO MARINE DRUGS
LA English
DT Article
DE algae extract; Cladophora glomerata; biosorption; trivalent chromium;
   EMS; ASCs
ID TNF-ALPHA; TISSUE; DIFFERENTIATION; TOLERANCE; CHROMIUM; GLUCOSE;
   HORSES; PONIES; BLOOD; ALGAE
AB This study investigated in vitro effects of freshwater alga Cladophora glomerata water extract enriched during a biosorption process in Cr(III) trivalent chromium and chromium picolinate on adipose-derived mesenchymal stromal stem cells (ASCs) and extracellular microvesicles (MVs) in equine metabolic syndrome-affected horses. Chemical characterisation of natural Cladophora glomerata was performed with special emphasis on: vitamin C, vitamin E, total phenols, fatty acids, free and protein-bound amino acids as well as measured Cr in algal biomass. To examine the influence of Cladophora glomerata water extracts, in vitro viability, oxidative stress factor accumulation, apoptosis, inflammatory response, biogenesis of mitochondria, autophagy in ASCs of EMS and secretory activity manifested by MV release were investigated. For this purpose, various methods of molecular biology and microscopic observations (i.e., immunofluorescence staining, SEM, TEM, FIB observations, mRNA and microRNA expression by RT-qPCR) were applied. The extract of Cladophora glomerata enriched with Cr(III) ions reduced apoptosis and inflammation in ASCs of EMS horses through improvement of mitochondrial dynamics, decreasing of PDK4 expression and reduction of endoplastic reticulum stress. Moreover, it was found, that Cladophora glomerata and Cr(III) induce antioxidative protection coming from enhanced SOD activity Therefore, Cladophora glomerata enriched with Cr(III) ions might become an interesting future therapeutic agent in the pharmacological treatment of EMS horses.
C1 [Marycz, Krzysztof; Kocherova, Ievgeniia; Maredziak, Monika] Wroclaw Univ Environm & Life Sci, Dept Expt Biol, Chelmonskiego 38 C, PL-50630 Wroclaw, Poland.
   [Marycz, Krzysztof] Wroclawskie Ctr Badan EIT, Stablowicka 147 St, PL-54066 Wroclaw, Poland.
   [Michalak, Izabela] Wroclaw Univ Sci & Technol, Dept Adv Mat Technol, Fac Chem, Smoluchowskiego 25 St, PL-50372 Wroclaw, Poland.
   [Weiss, Christine] PferdePraxis Dr Med Vet Daniel Weiss, Postmatte 14, CH-8807 Freienbach, Switzerland.
C3 Wroclaw University of Environmental & Life Sciences; Wroclaw University
   of Science & Technology
RP Marycz, K (corresponding author), Wroclaw Univ Environm & Life Sci, Dept Expt Biol, Chelmonskiego 38 C, PL-50630 Wroclaw, Poland.; Marycz, K (corresponding author), Wroclawskie Ctr Badan EIT, Stablowicka 147 St, PL-54066 Wroclaw, Poland.
EM krzysztof.marycz@upwr.edu.pl; izabela.michalak@pwr.edu.pl;
   kocherova.evgenia@gmail.com; monika.maredziak@upwr.edu.pl;
   d.weiss@horsedoc.ch
RI Kocherova, Ievgeniia/AAJ-2569-2020; Michalak, Izabela/P-3770-2015
OI Kocherova, Ievgeniia/0000-0003-2561-9750; Michalak,
   Izabela/0000-0001-8084-9642
FU National Science Centre in Poland [2015/18/E/NZ9/00607]; Wroclaw Centre
   of Biotechnology, Leading National Research Centre (KNOW, Krajowy
   Naukowy Osrodek Wiodacy) program
FX This project is financed in the framework of grant entitled "The effect
   of bioactive algae enriched by biosorption on the certain minerals such
   as Cr(III), Mg(II) and Mn(II) on the status of glucose in the course of
   metabolic syndrome horses. Evaluation in vitro and in vivo"
   (2015/18/E/NZ9/00607) attributed by The National Science Centre in
   Poland. Additionally, we acknowledge the Wroclaw Centre of
   Biotechnology, Leading National Research Centre (KNOW, Krajowy Naukowy
   Osrodek Wiodacy) program for years 2014-2018 for covering the
   publication fee.
CR AL-Suhaimi EA, 2013, EUR J MED RES, V18, DOI 10.1186/2047-783X-18-12
   Baraniak PR, 2010, REGEN MED, V5, P121, DOI 10.2217/RME.09.74
   Basinska K, 2015, J VET SCI, V16, P113, DOI [10.4142/jvs.2015.16.1.113, 10.4142/jvs.2015.16.1.107]
   BELAY A, 1993, J APPL PHYCOL, V5, P235, DOI 10.1007/BF00004024
   Berdalet E, 2016, J MAR BIOL ASSOC UK, V96, P61, DOI 10.1017/S0025315415001733
   Cao DJ, 2015, ECOTOX ENVIRON SAFE, V112, P231, DOI 10.1016/j.ecoenv.2014.11.007
   Chameroy KA, 2011, EQUINE VET J, V43, P494, DOI 10.1111/j.2042-3306.2010.00302.x
   CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1006/abio.1987.9999
   Cislo-Pakuluk A, 2017, STEM CELL REV REP, V13, P598, DOI 10.1007/s12015-017-9750-4
   Davidson Ian, 2003, Methods Mol Biol, V211, P111
   Durham AE, 2017, VET CLIN N AM-EQUINE, V33, P127, DOI 10.1016/j.cveq.2016.11.003
   Frank N, 2010, J VET INTERN MED, V24, P467, DOI 10.1111/j.1939-1676.2010.0503.x
   Geor RJ, 2008, J EQUINE VET SCI, V28, P753, DOI 10.1016/j.jevs.2008.10.016
   Hirabara SM, 2012, J BIOMED BIOTECHNOL, DOI 10.1155/2012/379024
   Hu S, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17020133
   Hua Y, 2012, J NUTR BIOCHEM, V23, P313, DOI 10.1016/j.jnutbio.2011.11.001
   Jeoung NH, 2008, AM J PHYSIOL-ENDOC M, V295, pE46, DOI 10.1152/ajpendo.00536.2007
   Johnson AR, 2012, IMMUNOL REV, V249, P218, DOI 10.1111/j.1600-065X.2012.01151.x
   Lee IK, 2014, DIABETES METAB J, V38, P181
   Lindåse S, 2016, ACTA VET SCAND, V58, DOI 10.1186/s13028-016-0246-z
   Liu Q, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/7803846
   Lopes HF, 2016, DIABETOL METAB SYNDR, V8, DOI 10.1186/s13098-016-0156-2
   Makki Kassem, 2013, ISRN Inflamm, V2013, P139239, DOI 10.1155/2013/139239
   Maredziak M, 2015, IN VITRO CELL DEV-AN, V51, P230, DOI 10.1007/s11626-014-9828-0
   Marycz K, 2012, VET MED-CZECH, V57, P610, DOI 10.17221/6469-VETMED
   Marycz K, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/3718468
   Marycz K, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/4710326
   Michalak I, 2011, J ANIM PHYSIOL AN N, V95, P374, DOI 10.1111/j.1439-0396.2010.01065.x
   Michalak I, 2017, ENG LIFE SCI, V17, P153, DOI 10.1002/elsc.201600012
   Michalak I, 2017, MOLECULES, V22, DOI 10.3390/molecules22010066
   Michalak I, 2015, OPEN CHEM, V13, P1341, DOI 10.1515/chem-2015-0149
   Michalak I, 2010, APPL BIOCHEM BIOTECH, V160, P1540, DOI 10.1007/s12010-009-8635-7
   Morgan R, 2015, VET REC, V177, P173, DOI 10.1136/vr.103226
   Nawrocka D, 2017, MAR DRUGS, V15, DOI 10.3390/md15080237
   Nicpon J, 2013, POL J VET SCI, V16, P753, DOI 10.2478/pjvs-2013-0107
   Patlolla AK, 2009, ENVIRON TOXICOL, V24, P66, DOI 10.1002/tox.20395
   Shalaby EA, 2011, PLANT SIGNAL BEHAV, V6, P1338, DOI 10.4161/psb.6.9.16779
   Shenouda SM, 2011, CIRCULATION, V124, P444, DOI 10.1161/CIRCULATIONAHA.110.014506
   Subramoniam A, 2012, INFLAMMATION, V35, P959, DOI 10.1007/s10753-011-9399-0
   Woodward AD, 2013, J EQUINE VET SCI, V33, P460, DOI 10.1016/j.jevs.2012.08.007
   Yu TZ, 2006, P NATL ACAD SCI USA, V103, P2653, DOI 10.1073/pnas.0511154103
   Zhou J, 2016, CURR TOP MED CHEM, V16, P823, DOI 10.2174/1568026615666150827094815
NR 42
TC 35
Z9 36
U1 2
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1660-3397
J9 MAR DRUGS
JI Mar. Drugs
PD DEC
PY 2017
VL 15
IS 12
AR 385
DI 10.3390/md15120385
PG 18
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FR6ZR
UT WOS:000419216500022
PM 29292726
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Aslanidi, OV
   Clayton, RH
   Lambert, JL
   Holden, AV
AF Aslanidi, OV
   Clayton, RH
   Lambert, JL
   Holden, AV
TI Dynamical and cellular electrophysiological mechanisms of ECG changes
   during ischaemia
SO JOURNAL OF THEORETICAL BIOLOGY
LA English
DT Article
DE Luo-Rudy model; transmural propagation; ECG; ischaemia; ST depression
ID ACTION-POTENTIAL DURATION; VENTRICULAR-FIBRILLATION; REGIONAL
   DIFFERENCES; MYOCARDIAL-ISCHEMIA; M-CELLS; SUBENDOCARDIAL ISCHEMIA;
   CARDIAC FIBRILLATION; COMPUTATIONAL MODEL; SYNDROME-X; PIG-HEART
AB The interpretation of normal and pathological electrocardiographic (ECG) patterns in terms of the underlying cellular and tissue electrophysiology is rudimentary, as the existing theories rely on geometrical aspects. We relate effects of sub-endocardial ischaemia on the ST-segment depression in ECG to patterns of transmural action potential propagation in a one-dimensional virtual ventricular wall. Our computational study exposes two electrophysiological mechanisms of ST depression: dynamic-predominantly positive spatial gradients in the membrane potential during abnormal repolarization of the wall, produced by action potential duration changes in the ischaemic region; and static-a negative spatial gradient of the resting membrane potential between the normal and ischaemic regions. Hyperkalaemia is the major contributor to both these mechanisms at the cellular level. These results complement simulations of the effects of cardiac geometry on the ECG, and dissect spatio-temporal and cellular electrophysiological mechanisms of ST depression seen in sub-endocardial ischaemia. (c) 2005 Elsevier Ltd. All rights reserved.
C1 Univ Leeds, Sch Biomed Sci, Leeds LS2 9JT, W Yorkshire, England.
   Univ Sheffield, Dept Comp Sci, Sheffield S1 4DP, S Yorkshire, England.
   Univ Leeds, Sch Med, Leeds LS2 9JT, W Yorkshire, England.
C3 University of Leeds; University of Sheffield; University of Leeds
RP Univ Leeds, Sch Biomed Sci, Leeds LS2 9JT, W Yorkshire, England.
EM arun@cbiol.leeds.ac.uk
RI Clayton, Richard/CAF-3400-2022
OI Aslanidi, Oleg/0000-0003-4813-7682; Clayton, Richard/0000-0002-8438-7518
CR Antzelevitch C, 1999, J CARDIOVASC ELECTR, V10, P1124, DOI 10.1111/j.1540-8167.1999.tb00287.x
   Aslanidi OV, 2002, CHAOS, V12, P843, DOI 10.1063/1.1500496
   ASLANIDI OV, 2005, IN PRESS PHIL T R SO
   Berenfeld O, 1998, CIRC RES, V82, P1063, DOI 10.1161/01.RES.82.10.1063
   Botker HE, 1999, J AM COLL CARDIOL, V33, P1056, DOI 10.1016/S0735-1097(98)00683-4
   Botker HE, 1998, AM J CARDIOL, V82, P1352, DOI 10.1016/S0002-9149(98)00640-7
   Bryant SM, 1998, CARDIOVASC RES, V40, P322, DOI 10.1016/S0008-6363(98)00133-3
   Clayton RH, 2004, PROG BIOPHYS MOL BIO, V85, P473, DOI 10.1016/j.pbiomolbio.2003.12.002
   Clayton RH, 2004, IEEE T BIO-MED ENG, V51, P28, DOI 10.1109/TBME.2003.820356
   Clayton RH, 2002, PHYSIOL MEAS, V23, P707, DOI 10.1088/0967-3334/23/4/310
   Clayton RH, 2001, J THEOR BIOL, V208, P215, DOI 10.1006/jtbi.2000.2212
   CLAYTON RH, 1991, AUTOMATIC RECORDING, P685
   Conrath CE, 2004, CARDIOVASC RES, V62, P407, DOI 10.1016/j.cardiores.2004.02.016
   de Groot JR, 2004, CARDIOVASC RES, V62, P323, DOI 10.1016/j.cardiores.2004.01.033
   GESELOWITZ DB, 1983, ANN BIOMED ENG, V11, P191, DOI 10.1007/BF02363286
   Gima K, 2002, CIRC RES, V90, P889, DOI 10.1161/01.RES.0000016960.61087.86
   Gray RA, 1998, NATURE, V392, P75, DOI 10.1038/32164
   GRAY RA, 1995, SCIENCE, V270, P1222, DOI 10.1126/science.270.5239.1222
   Hamada K, 1998, JPN J PHARMACOL, V76, P149, DOI 10.1254/jjp.76.149
   HOLLAND RP, 1977, PROG CARDIOVASC DIS, V19, P431, DOI 10.1016/0033-0620(77)90009-3
   HOLLAND RP, 1977, J CLIN INVEST, V60, P197, DOI 10.1172/JCI108757
   Hopenfeld B, 2004, J CARDIOVASC ELECTR, V15, P1200, DOI 10.1046/j.1540-8167.2004.04072.x
   Horacek B Milan, 2002, Card Electrophysiol Rev, V6, P196, DOI 10.1023/A:1016352205286
   Hyatt CJ, 2003, BIOPHYS J, V85, P2673, DOI 10.1016/S0006-3495(03)74690-6
   Jalife J, 2000, ANNU REV PHYSIOL, V62, P25, DOI 10.1146/annurev.physiol.62.1.25
   Kirchhof PF, 1996, CARDIOVASC RES, V31, P953
   Kohl P, 2000, PHILOS T R SOC A, V358, P579, DOI 10.1098/rsta.2000.0547
   LEW AS, 1987, J AM COLL CARDIOL, V10, P519, DOI 10.1016/S0735-1097(87)80193-6
   LEW AS, 1985, AM J CARDIOL, V55, P883, DOI 10.1016/0002-9149(85)90711-8
   Li DS, 1998, CIRC RES, V82, P957, DOI 10.1161/01.RES.82.9.957
   LIU DW, 1993, CIRC RES, V72, P671, DOI 10.1161/01.RES.72.3.671
   LUO CH, 1994, CIRC RES, V74, P1071, DOI 10.1161/01.RES.74.6.1071
   Nabauer M, 1996, CIRCULATION, V93, P168, DOI 10.1161/01.CIR.93.1.168
   OOSTERON A, 2002, J ELECTROCARDIOL, V35, pS181
   Pak HN, 2004, J CARDIOVASC ELECTR, V15, P1357, DOI 10.1046/j.1540-8167.2004.03569.x
   PLONSEY R, 2000, BIOELECTRICITY QUANT, P149
   Seemann G, 2003, J CARDIOVASC ELECTR, V14, pS219, DOI 10.1046/j.1540.8167.90314.x
   Shaw RM, 1997, CARDIOVASC RES, V35, P256, DOI 10.1016/S0008-6363(97)00093-X
   Shipsey SJ, 1997, CIRCULATION, V96, P2061, DOI 10.1161/01.CIR.96.6.2061
   Stankovicova T, 2000, CARDIOVASC RES, V45, P952, DOI 10.1016/S0008-6363(99)00418-6
   STARMER CF, 1993, BIOPHYS J, V65, P1775, DOI 10.1016/S0006-3495(93)81233-5
   TACCARDI B, 1994, CIRCULATION, V90, P3076, DOI 10.1161/01.CIR.90.6.3076
   Viswanathan PC, 2000, CIRCULATION, V101, P1192, DOI 10.1161/01.CIR.101.10.1192
   Watanabe I, 1997, J CARDIOVASC ELECTR, V8, P1229, DOI 10.1111/j.1540-8167.1997.tb01012.x
   WEISS J, 1986, AM J PHYSIOL, V250, pH982, DOI 10.1152/ajpheart.1986.250.6.H982
   Yan GX, 1998, CIRCULATION, V98, P1921, DOI 10.1161/01.CIR.98.18.1921
NR 46
TC 26
Z9 30
U1 0
U2 5
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0022-5193
EI 1095-8541
J9 J THEOR BIOL
JI J. Theor. Biol.
PD DEC 21
PY 2005
VL 237
IS 4
BP 369
EP 381
DI 10.1016/j.jtbi.2005.04.022
PG 13
WC Biology; Mathematical & Computational Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational
   Biology
GA 989JE
UT WOS:000233667900004
PM 15979649
DA 2025-06-11
ER

PT J
AU Tien, N
   Wu, TY
   Lai, JN
   Lin, CL
   Hsiao, YC
   Khaw, JY
   Lim, YP
AF Tien, Ni
   Wu, Tien-Yuan
   Lai, Jung-Nien
   Lin, Cheng-Li
   Hsiao, Yu-Chi
   Khaw, Jie-Yee
   Lim, Yun-Ping
TI Influences of antidepressant medications on the risk of developing
   hyperlipidemia in patients with depression by a population-based cohort
   study and on in vitro hepatic lipogenic-related gene expression
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Antidepressant medications; Hyperlipidemia; Cohort study;
   Lipogenesis
ID SEROTONIN REUPTAKE INHIBITORS; DENSITY-LIPOPROTEIN CHOLESTEROL;
   CORONARY-HEART-DISEASE; METABOLIC SYNDROME; CEREBROVASCULAR EVENTS;
   SERUM CONCENTRATIONS; STROKE; ASSOCIATION; DISORDER; METAANALYSIS
AB Background: Depression increases the risk of cardiovascular disease (CVD). The association between antidepressant medications (ADMs) and CVD remains controversial. Hyperlipidemia is a risk factor for CVD. We conducted a nationwide population-based retrospective cohort study to examine depression and ADM use on the risk of developing hyperlipidemia. The effects of ADMs on the expression of lipogenesis-related hepatic genes were also evaluated.
   Methods: We obtained data from the Longitudinal Health Insurance Database of Taiwan on patients with new-onset depression and a comparison cohort without depression. A Cox proportional hazards regression model was used to analyze the differences in the risk of developing hyperlipidemia between these two cohorts. We also examined the influence of ADMs on the expression of lipogenesis-related hepatic genes.
   Results: After adjustment for comorbidities and confounding factors, the case group (N = 38,322) had a higher risk for hyperlipidemia than that of the control cohort (N = 38,322) [adjusted hazards ratio (aHR)=1.16]. Patients with depression who did not receive ADM therapy exhibited a significantly higher risk of hyperlipidemia (aHR = 1.61). However, in patients with depression treated with ADMs, the risk of developing hyperlipidemia was significantly lowered compared to the patients without ADMs (all aHR < 0.81). Gene expression analysis indicated that ADMs downregulated the expression of lipogenesis-related hepatic genes.
   Limitations: Unmeasured confounding risk factors for hyperlipidemia might not have been included in the study.
   Conclusions: ADMs reduced hyperlipidemia risk in patients with depression, partly by downregulating the expression of lipogenesis-related genes and improving the patients' lipid profiles. Early diagnosis and management of hyperlipidemia would further facilitate the prevention of CVD.
C1 [Tien, Ni] China Med Univ Hosp, Dept Lab Med, Taichung, Taiwan.
   [Tien, Ni] China Med Univ, Dept Med Lab Sci & Biotechnol, Taichung, Taiwan.
   [Wu, Tien-Yuan] Buddhist Tzu Chi Med Fdn, Taichung Tzu Chi Hosp, Dept Pharm, Taichung, Taiwan.
   [Wu, Tien-Yuan] Tzu Chi Univ, Sch Med, Dept Pharmacol, Hualien, Taiwan.
   [Lai, Jung-Nien] China Med Univ Hosp, Dept Chinese Med, Taichung, Taiwan.
   [Lai, Jung-Nien] China Med Univ, Coll Chinese Med, Sch Chinese Med, Taichung, Taiwan.
   [Lin, Cheng-Li] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan.
   [Hsiao, Yu-Chi; Khaw, Jie-Yee; Lim, Yun-Ping] China Med Univ, Coll Pharm, Dept Pharm, 100,Sec 1,Jingmao Rd, Taichung 406040, Taiwan.
   [Lim, Yun-Ping] China Med Univ Hosp, Dept Internal Med, Taichung, Taiwan.
   [Lim, Yun-Ping] China Med Univ Hosp, Dept Med Res, Taichung, Taiwan.
C3 China Medical University Taiwan; China Medical University Hospital -
   Taiwan; China Medical University Taiwan; Buddhist Tzu Chi General
   Hospital; Taichung Tzu Chi Hospital; Tzu Chi University; China Medical
   University Taiwan; China Medical University Hospital - Taiwan; China
   Medical University Taiwan; China Medical University Taiwan; China
   Medical University Hospital - Taiwan; China Medical University Taiwan;
   China Medical University Taiwan; China Medical University Hospital -
   Taiwan; China Medical University Taiwan; China Medical University
   Hospital - Taiwan
RP Wu, TY (corresponding author), Buddhist Tzu Chi Med Fdn, Taichung Tzu Chi Hosp, Dept Pharm, Taichung, Taiwan.; Wu, TY (corresponding author), Tzu Chi Univ, Sch Med, Dept Pharmacol, Hualien, Taiwan.; Lim, YP (corresponding author), China Med Univ, Coll Pharm, Dept Pharm, 100,Sec 1,Jingmao Rd, Taichung 406040, Taiwan.
EM limyp@mail2000.com.tw
RI Wu, Tien-Yuan/AAV-6964-2020; Liao, Yu-Chi/AAT-1357-2021
OI Lin, Cheng-Li/0000-0001-9926-3668
FU Ministry of Science and Technology, Taiwan, R.O.C.
   [MOST110-2320-B-039-016-MY3]; China Medical University Hospital,
   Taichung, Taiwan [DMR-107-109]; China Medical University, Taichung,
   Taiwan [CMU110-MF-29]; Buddhist Tzu Chi Medical Foundation
   [TTCRD110-28]; Taiwan Ministry of Health and Welfare Clinical Trial
   Center [MOHW110-TDU-B-212-124,004]; MOST Clinical Trial Consortium for
   Stroke [MOST109-2321-B-039-002]; China Medical University Hospital
   [DMR-109-231]; Tseng-Lien Lin Foundation, Taichung, Taiwan
FX This study was supported by the Ministry of Science and Technology,
   Taiwan, R.O.C. (MOST110-2320-B-039-016-MY3); China Medical University
   Hospital, Taichung, Taiwan (DMR-107-109); China Medical University,
   Taichung, Taiwan (CMU110-MF-29); Taichung Tzu Chi Hospital, Buddhist Tzu
   Chi Medical Foundation (TTCRD110-28); and in part by Taiwan Ministry of
   Health and Welfare Clinical Trial Center (MOHW110-TDU-B-212-124,004);
   MOST Clinical Trial Consortium for Stroke (MOST109-2321-B-039-002);
   China Medical University Hospital (DMR-109-231); and Tseng-Lien Lin
   Foundation, Taichung, Taiwan.
CR Alloubani A, 2021, CURR CARDIOL REV, V17, DOI 10.2174/1573403X16999201210200342
   Bak S, 2002, STROKE, V33, P1465, DOI 10.1161/01.STR.0000018589.56991.BA
   Barbui C, 2005, INT CLIN PSYCHOPHARM, V20, P169, DOI 10.1097/00004850-200505000-00008
   Barlinn K, 2015, NEUROPSYCH DIS TREAT, V11, P1, DOI 10.2147/NDT.S63904
   Beck A, 2021, SYST REV-LONDON, V10, DOI 10.1186/s13643-020-01568-3
   Broncel M., 2016, OPEN MED J, V3, P352
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   CARNEY RM, 1988, PSYCHOSOM MED, V50, P627, DOI 10.1097/00006842-198811000-00009
   Changchien C.S., 2003, J MED ULTRASOUND, V11, P60, DOI [10.1016/S0929-6441(09)60043-6, DOI 10.1016/S0929-6441(09)60043-6]
   Chen Y, 2008, ANN PHARMACOTHER, V42, P177, DOI 10.1345/aph.1K369
   Chien IC, 2013, J PSYCHOSOM RES, V75, P270, DOI 10.1016/j.jpsychores.2013.06.003
   Crichton GE, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-3170-2
   Fittipaldi EOD, 2020, ARQ BRAS CARDIOL, V115, P462
   de Abajo FJ, 2000, BRIT J CLIN PHARMACO, V50, P43, DOI 10.1046/j.1365-2125.2000.00216.x
   Dong JY, 2012, STROKE, V43, P32, DOI 10.1161/STROKEAHA.111.630871
   Douglas I, 2011, BRIT J CLIN PHARMACO, V71, P116, DOI 10.1111/j.1365-2125.2010.03797.x
   Fanelli G., 2021, BMJ, P1
   GBD, 2017, GLOBAL REGIONAL NATL, V392, P1789, DOI [10.1016/S0140-6736(18)32279-7, DOI 10.1016/S0140-6736(18)32279-7]
   Gheshlagh RG, 2016, IRAN RED CRESCENT ME, V18, DOI 10.5812/ircmj.26523
   Higuchi N, 2008, HEPATOL RES, V38, P1122, DOI 10.1111/j.1872-034X.2008.00382.x
   Hing Esther, 2010, Natl Health Stat Report, P1
   Hsu JH, 2012, GEN HOSP PSYCHIAT, V34, P360, DOI 10.1016/j.genhosppsych.2012.02.004
   Huang CI, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0174574
   Hung CC, 2013, AM J GERIAT PSYCHIAT, V21, P811, DOI 10.1016/j.jagp.2013.01.018
   Jung I, 2021, DIABETES METAB J, V45, P379, DOI 10.4093/dmj.2020.0008
   Kahl KG, 2012, EUR ARCH PSY CLIN N, V262, P313, DOI 10.1007/s00406-011-0277-4
   Kale P, 2015, FRONT PHARMACOL, V6, DOI 10.3389/fphar.2015.00224
   Kharofa J, 2007, STROKE, V38, P3049, DOI 10.1161/STROKEAHA.107.491472
   Kilbourne AM, 2008, J GEN INTERN MED, V23, P1628, DOI 10.1007/s11606-008-0720-z
   Knuth D.E., 1981, Seminumerical Algorithms
   Kozumplik O, 2011, PSYCHIAT DANUB, V23, P84
   Leo RJ, 2006, CURR OPIN INVEST DR, V7, P637
   Leucht S, 2001, J CLIN PSYCHOPHARM, V21, P432, DOI 10.1097/00004714-200108000-00011
   Lewis A, 2010, CURR ATHEROSCLER REP, V12, P225, DOI 10.1007/s11883-010-0117-4
   Li YW, 2018, ARCH TOXICOL, V92, P2829, DOI 10.1007/s00204-018-2263-3
   Lunghi C, 2021, DIABETES RES CLIN PR, V171, DOI 10.1016/j.diabres.2020.108566
   MAGUIRE KP, 1981, BRIT J CLIN PHARMACO, V12, P405, DOI 10.1111/j.1365-2125.1981.tb01235.x
   Marazziti D, 2014, CNS SPECTRUMS, V19, P293, DOI 10.1017/S1092852913000667
   Mathews MJ, 2015, BMC CARDIOVASC DISOR, V15, DOI 10.1186/s12872-015-0074-5
   Nahas R, 2011, CAN FAM PHYSICIAN, V57, P659
   Nakao M, 2004, TOHOKU J EXP MED, V204, P273, DOI 10.1620/tjem.204.273
   Nebhinani N, 2020, DIAB MET SYND CLIN R, V14, P1997, DOI 10.1016/j.dsx.2020.10.013
   Nicholson A, 2006, EUR HEART J, V27, P2763, DOI 10.1093/eurheartj/ehl338
   Park JH, 2021, EUR CHILD ADOLES PSY, V30, P261, DOI 10.1007/s00787-020-01511-w
   PARK SK, 1988, COMMUN ACM, V31, P1192, DOI 10.1145/63039.63042
   Reis M, 2009, THER DRUG MONIT, V31, P42, DOI 10.1097/FTD.0b013e31819114ea
   RIGAL JG, 1987, J CLIN PSYCHOPHARM, V7, P222
   Rugulies R, 2002, AM J PREV MED, V23, P51, DOI 10.1016/S0749-3797(02)00439-7
   Saari K, 2004, J CLIN PSYCHIAT, V65, P547
   Scherrer JF, 2011, AM J MED, V124, P318, DOI 10.1016/j.amjmed.2010.11.015
   Schultz JR, 2000, GENE DEV, V14, P2831, DOI 10.1101/gad.850400
   Smoller JW, 2009, ARCH INTERN MED, V169, P2128, DOI 10.1001/archinternmed.2009.436
   So HC, 2021, PSYCHOL MED, V51, P2357, DOI 10.1017/S0033291720000951
   Swenson JR, 2006, CAN J PSYCHIAT, V51, P923, DOI 10.1177/070674370605101408
   Vanhala M, 2009, ACTA PSYCHIAT SCAND, V119, P137, DOI 10.1111/j.1600-0447.2008.01283.x
   Vukotic NT, 2021, ARCH TOXICOL, V95, P767, DOI 10.1007/s00204-020-02963-4
   Waldschmitt C, 2009, PHARMACOPSYCHIATRY, V42, P189, DOI 10.1055/s-0029-1220890
   WATANABE S, 1980, FOLIA PSYCHIAT NEU J, V34, P147
   Wen Y, 2021, NEUROPSYCH DIS TREAT, V17, P57, DOI 10.2147/NDT.S280716
   WILLY PJ, 1995, GENE DEV, V9, P1033, DOI 10.1101/gad.9.9.1033
   Wu CS, 2011, AM J PSYCHIAT, V168, P511, DOI 10.1176/appi.ajp.2010.10071064
   Wu KM, 2019, NUTR METAB, V16, DOI 10.1186/s12986-019-0356-5
   Zhang C, 2020, J PSYCHIATR RES, V130, P9, DOI 10.1016/j.jpsychires.2020.07.012
NR 64
TC 4
Z9 4
U1 0
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD DEC 1
PY 2021
VL 295
BP 271
EP 283
DI 10.1016/j.jad.2021.08.041
EA SEP 2021
PG 13
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA YE7XT
UT WOS:000741334700036
PM 34482059
OA hybrid
DA 2025-06-11
ER

PT J
AU Garcez, A
   Leite, HM
   Weiderpass, E
   Paniz, VMV
   Watte, G
   Canuto, R
   Olinto, MTA
AF Garcez, Anderson
   Leite, Heloisa Marquardt
   Weiderpass, Elisabete
   Vieira Paniz, Vera Maria
   Watte, Guilherme
   Canuto, Raquel
   Anselmo Olinto, Maria Teresa
TI Basal cortisol levels and metabolic syndrome: A systematic review and
   meta analysis of observational studies
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE Cortisol; Metabolic syndrome; Observational studies; Systematic review;
   Meta-analysis
ID PITUITARY-ADRENAL AXIS; SALIVARY CORTISOL; CARDIOVASCULAR RISK;
   ASSOCIATION; OBESITY; STRESS; METAANALYSIS; PREVALENCE; LIFE; DEPRESSION
AB Objective: To perform a qualitative synthesis (systematic review) and quantitative analysis (meta-analysis) to summarize the evidence regarding the relationship between basal cortisol levels and metabolic syndrome (MetS) in adults.
   Methods: A systematic search was performed in the PubMed, Embase, and PsycINFO databases for observational studies on the association between basal cortisol levels and MetS. The quality of individual studies was assessed by the Newcastle-Ottawa score. A random effects model was used to report pooled quantitative results and the I-2 statistic was used to assess heterogeneity. Egger's and Begg's tests were used to evaluate publication bias.
   Results: Twenty-six studies (19 cross-sectional and seven case-control) met the inclusion criteria for the systematic review. The majority was classified as having a low risk of bias and used established criteria for the diagnosis of MetS. Twenty-one studies provided data on basal cortisol levels as continuous values and were included in the meta-analysis; they comprised 35 analyses and 11,808 subjects. Pooled results showed no significant difference in basal cortisol levels between subjects with and without MetS (standardized mean difference [SMD] = 0.02, 95% confidence interval [CI] = -0.11 to 0.14). There was high heterogeneity between the studies when all comparisons were considered (I-2 = 83.1%;p < 0.001). Paradoxically, meta-analysis of studies evaluating saliva samples showed no significantly lower basal cortisol levels among subjects with MetS (SMD = -0.18, 95% CI = -0.37 to 0.01), whereas those studies that evaluated serum samples (SMD = 0.11, 95% CI = -0.02 to 0.24) and urine samples (SMD = 0.73, 95% CI = -0.40 to 1.86) showed no significantly higher basal cortisol levels among subjects with MetS. In the subgroup and meta-regression analyses, a significant difference in basal cortisol levels was observed according to study design, population base, age, gender, cortisol level assessment method, and study quality.
   Conclusion: This systematic review and meta-analysis does not reveal any association between basal cortisol levels and MetS based on results of observational studies. The results of a random-effect meta-analysis showed no significant difference in basal cortisol levels between subjects with and without MetS. The present findings should be considered in order to help future studies.
C1 [Garcez, Anderson; Leite, Heloisa Marquardt; Vieira Paniz, Vera Maria; Anselmo Olinto, Maria Teresa] Univ Vale Rio Sinos UNISINOS, Postgrad Program Collect Hlth, Sao Leopoldo, RS, Brazil.
   [Weiderpass, Elisabete] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
   [Weiderpass, Elisabete] Canc Registry Norway, Inst Populat Based Canc Res, Dept Res, Oslo, Norway.
   [Weiderpass, Elisabete] Univ Tromso, Dept Community Med, Fac Hlth Sci, Tromso, Norway.
   [Weiderpass, Elisabete] Arctic Univ Norway, Univ Tromso, Tromso, Norway.
   [Weiderpass, Elisabete] Folkhalsan Res Ctr, Genet Epidemiol Grp, Helsinki, Finland.
   [Watte, Guilherme] Pavilhao Pereira Filho, Irmandade Santa Casa Misericordia Porto Alegre, Dept Resp Med & Thorac Surg, Porto Alegre, RS, Brazil.
   [Canuto, Raquel] Fed Univ Rio Grande do Sul State UFRGS, Dept Nutr, Porto Alegre, RS, Brazil.
   [Anselmo Olinto, Maria Teresa] Fed Univ Hlth Sci Porto Alegre UFCSPA, Dept Nutr, Porto Alegre, RS, Brazil.
C3 Universidade do Vale do Rio dos Sinos (Unisinos); Karolinska Institutet;
   University of Oslo; UiT The Arctic University of Tromso; UiT The Arctic
   University of Tromso; Folkhalsan Research Center; Universidade Federal
   do Rio Grande do Sul; Universidade Federal de Ciencias da Saude de Porto
   Alegre
RP Olinto, MTA (corresponding author), Univ Vale Rio dos Sinos, Av Unisinos 950,CP 275, BR-93022000 Sao Leopoldo, RS, Brazil.
EM mtolinto@gmail.com
RI Canuto, Raquel/AAV-8688-2020; Garcez, Anderson/AAH-5877-2021; Olinto,
   Maria/AAH-5897-2021; Leite, Heloisa/LFL-2582-2024; Watte,
   G./ABC-7864-2020; Paniz, Vera/AAJ-8450-2020; Weiderpass,
   Elisabete/M-4029-2016
OI Watte, Guilherme/0000-0002-6948-3982; Weiderpass,
   Elisabete/0000-0003-2237-0128; Marquardt Leite,
   Heloisa/0000-0002-5955-2294
FU National Council of Technological and Scientific Development (Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologic - CNPq - Brazilian
   Government) [307257/2013-4]; National Council of Technological and
   Scientific Development - CNPq (Brazilian Government) [207314/2015-2]
FX MTAO was supported by the National Council of Technological and
   Scientific Development (Conselho Nacional de Desenvolvimento Cientifico
   e Tecnologic - CNPq - Brazilian Government) through research
   productivity fellowship under grant agreement number 307257/2013-4. AG
   was supported by the National Council of Technological and Scientific
   Development - CNPq (Brazilian Government) through sandwich doctorate
   fellowship at the Department of Medical Epidemiology and Biostatistics,
   Karolinska Institutet, Stockholm, Sweden under grant number
   207314/2015-2. The funders had no role in the study design, data
   collection and analysis, decision to publish and preparation or approval
   of the manuscript.
CR Abraham SB, 2013, OBESITY, V21, pE105, DOI 10.1002/oby.20083
   Adam EK, 2009, PSYCHONEUROENDOCRINO, V34, P1423, DOI 10.1016/j.psyneuen.2009.06.011
   Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Almadi T, 2013, PSYCHOPHYSIOLOGY, V50, P821, DOI 10.1111/psyp.12069
   Anagnostis P, 2009, J CLIN ENDOCR METAB, V94, P2692, DOI 10.1210/jc.2009-0370
   Austin-Ketch TL, 2010, DIABETES METAB SYND, V4, P82, DOI 10.1016/j.dsx.2010.01.008
   Baudrand R, 2011, STEROIDS, V76, P1575, DOI 10.1016/j.steroids.2011.09.010
   BEGG CB, 1994, BIOMETRICS, V50, P1088, DOI 10.2307/2533446
   Beltrán-Sánchez H, 2013, J AM COLL CARDIOL, V62, P697, DOI 10.1016/j.jacc.2013.05.064
   Bengtsson I, 2010, METABOLISM, V59, P1012, DOI 10.1016/j.metabol.2009.10.024
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Corbalán-Tutau D, 2014, PHYSIOL BEHAV, V123, P231, DOI 10.1016/j.physbeh.2012.06.005
   DeSantis AS, 2011, J CLIN ENDOCR METAB, V96, P3483, DOI 10.1210/jc.2011-0483
   do Nascimento FV, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/s13098-015-0036-1
   Egger M, 1997, BMJ-BRIT MED J, V315, P629, DOI 10.1136/bmj.315.7109.629
   Esteghamati A, 2011, CLIN INVEST MED, V34, pE131, DOI 10.25011/cim.v34i3.15185
   Fabre B, 2013, STRESS, V16, P16, DOI 10.3109/10253890.2012.676112
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Garcez A, 2017, HORM METAB RES, V49, P510, DOI 10.1055/s-0043-101822
   GUERRA Aline, 2015, Arq. Gastroenterol., V52, P88, DOI 10.1590/S0004-28032015000200003
   Hellhammer DH, 2009, PSYCHONEUROENDOCRINO, V34, P163, DOI 10.1016/j.psyneuen.2008.10.026
   Higgins JPT, 2002, STAT MED, V21, P1539, DOI 10.1002/sim.1186
   Hui WS, 2010, EUR J EPIDEMIOL, V25, P375, DOI 10.1007/s10654-010-9459-z
   Jang YM, 2012, DIABETES METAB J, V36, P245, DOI 10.4093/dmj.2012.36.3.245
   Kajantie E, 2004, CLIN ENDOCRINOL, V60, P201, DOI 10.1046/j.1365-2265.2003.01965.x
   Kazakou P, 2012, HORM METAB RES, V44, P839, DOI 10.1055/s-0032-1311632
   Laaksonen DE, 2004, DIABETES CARE, V27, P1036, DOI 10.2337/diacare.27.5.1036
   Lee SY, 2007, DIABETES RES CLIN PR, V75, P72, DOI 10.1016/j.diabres.2006.04.013
   Levine A, 2007, PHYSIOL BEHAV, V90, P43, DOI 10.1016/j.physbeh.2006.08.025
   Licht CMM, 2010, J CLIN ENDOCR METAB, V95, P2458, DOI 10.1210/jc.2009-2801
   Maggio M, 2007, AM J PHYSIOL-ENDOC M, V292, pE353, DOI 10.1152/ajpendo.00339.2006
   Maggio M, 2006, J AM GERIATR SOC, V54, P1832, DOI 10.1111/j.1532-5415.2006.00963.x
   Martins CS, 2017, DIABETES-METAB RES, V33, DOI 10.1002/dmrr.2842
   Miulescu RD, 2009, FARMACIA, V57, P721
   Moher D, 2009, J CLIN EPIDEMIOL, V62, P1006, DOI 10.1016/j.jclinepi.2009.06.005
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Mozumdar A, 2011, DIABETES CARE, V34, P216, DOI 10.2337/dc10-0879
   Nano J, 2016, DIABETES METAB
   Özçelik E, 2010, DIABETES METAB SYND, V4, P13, DOI 10.1016/j.dsx.2010.01.005
   Park SB, 2011, J KOREAN MED SCI, V26, P914, DOI 10.3346/jkms.2011.26.7.914
   Pasquali R, 2006, ANN NY ACAD SCI, V1083, P111, DOI 10.1196/annals.1367.009
   Phillips AC, 2010, EUR J ENDOCRINOL, V162, P919, DOI 10.1530/EJE-09-1078
   Ragnarsson O, 2015, STEROIDS, V101, P71, DOI 10.1016/j.steroids.2015.06.007
   Rosmond R, 2005, PSYCHONEUROENDOCRINO, V30, P1, DOI 10.1016/j.psyneuen.2004.05.007
   Russell E, 2012, PSYCHONEUROENDOCRINO, V37, P589, DOI 10.1016/j.psyneuen.2011.09.009
   Stroup DF, 2000, JAMA-J AM MED ASSOC, V283, P2008, DOI 10.1001/jama.283.15.2008
   Tomlinson JW, 2004, ENDOCR REV, V25, P831, DOI 10.1210/er.2003-0031
   Udenze Ifeoma Christiana, 2017, Pan Afr Med J, V26, P52, DOI 10.11604/pamj.2017.26.52.9909
   van Dijk GM, 2015, MATURITAS, V80, P140, DOI 10.1016/j.maturitas.2014.11.016
   Vogelzangs N, 2007, PSYCHONEUROENDOCRINO, V32, P151, DOI 10.1016/j.psyneuen.2006.11.009
   Vogelzangs N, 2009, AM J GERIAT PSYCHIAT, V17, P716, DOI 10.1097/JGP.0b013e3181aad5d7
   Wan X, 2014, BMC MED RES METHODOL, V14, DOI 10.1186/1471-2288-14-135
   Wang Minghan, 2005, Nutr Metab (Lond), V2, P3, DOI 10.1186/1743-7075-2-3
   Wells G.A., 2019, The Newcastle-OttawaScale (NOS) for assessing the quality of non randomized studies in meta-analyses
NR 57
TC 14
Z9 14
U1 0
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD SEP
PY 2018
VL 95
BP 50
EP 62
DI 10.1016/j.psyneuen.2018.05.023
PG 13
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA GU9YO
UT WOS:000445713400007
PM 29800780
DA 2025-06-11
ER

PT J
AU Ozku, F
   Turkon, H
   Cakir, DU
   Eroglu, M
   Tutunculer, FK
   Faydaci, U
   Ukinç, K
   Asik, M
AF Ozku, Faruk
   Turkon, Hakan
   Cakir, Dilek Ulker
   Eroglu, Mustafa
   Tutunculer, Funda Kirtay
   Faydaci, Umut
   Ukinc, Kubilay
   Asik, Mehmet
TI SERUM ISCHEMIA MODIFIED ALBUMIN LEVELS IN SUBCLINICAL CUSHING'S SYNDROME
SO ACTA MEDICA MEDITERRANEA
LA English
DT Article
DE Ischemia-modified albumin; adrenal incidentaloma; subclinical Cushing's
   syndrome; oxidative stress
ID ADRENAL INCIDENTALOMA
AB Introduction: Subclinical Cushing's syndrome (SCS) is defined as biochemical overt cortisol excess in the absence of the classical signs and symptoms of Cushing's disease. The prevalence of SCS is reported as between approximately 5% and 24% in patients with adrenal incidentalomas (AI). SCS has increased cardiovascular and metabolic risk factors, and metabolic syndrome. Recently some studies demonstrated oxidative stress enhancement in Cushing's disease. Ischemia-modified albumin (IMA) is a marker of ischemia and oxidative stress and is increased in different clinical conditions such as cardiovascular diseases and metabolic syndrome. However, it has not been investigated in the patients with SCS. We aimed to evaluate serum IMA levels in the patients with SCS.
   Materials and methods: A total of 128 patients with AI were included in this study (17 patients with SCS and 111 patients with non-functional adenomas (NFA)). All patients were evaluated for the presence of adrenal masses using adrenal computed tomography (CT) scans. Serum IMA levels were measured by using a calorimetric method.
   Results: Serum IMA levels were significantly higher in SCS patients than in NFA patients (p < 0.05). Serum IMA was significantly correlated with waist circumference, low-density lipoprotein (LDL) levels and SCS. Furthermore, regression analysis revealed that serum IMA levels are independent and positively associated only with SCS.
   Conclusion: We concluded that elevated serum IMA levels might be accepted as a useful marker in patients with SCS. In order to reveal the pathological role of IMA levels in patients with SCS more studies are required.
C1 [Ozku, Faruk] Canakkale Onsekiz Mart Univ, Fac Med, Dept Gen Surg, TR-17100 Canakkale, Turkey.
   [Turkon, Hakan; Cakir, Dilek Ulker; Tutunculer, Funda Kirtay] Canakkale Onsekiz Mart Univ, Fac Med, Dept Med Biochem, TR-17100 Canakkale, Turkey.
   [Eroglu, Mustafa; Ukinc, Kubilay; Asik, Mehmet] Canakkale Onsekiz Mart Univ, Fac Med, Dept Endocrinol, TR-17100 Canakkale, Turkey.
   [Eroglu, Mustafa; Ukinc, Kubilay; Asik, Mehmet] Canakkale Onsekiz Mart Univ, Fac Med, Dept Metab, TR-17100 Canakkale, Turkey.
   [Faydaci, Umut] Near East Univ, Fac Med, Dept Gen Surg, Nicosia, Cyprus.
C3 Canakkale Onsekiz Mart University; Canakkale Onsekiz Mart University;
   Canakkale Onsekiz Mart University; Canakkale Onsekiz Mart University;
   Near East University
RP Turkon, H (corresponding author), Canakkale Onsekiz Mart Univ, Fac Med, Dept Med Biochem, TR-17100 Canakkale, Turkey.
RI Eren, Mehmet/LBI-2705-2024; Eroğlu, Mustafa/AAC-1081-2020; Ukinc,
   KUBILAY/E-7111-2018
OI Ukinc, KUBILAY/0000-0002-4727-7432
CR Arnaldi G, 2012, BEST PRACT RES CL EN, V26, P405, DOI 10.1016/j.beem.2011.12.006
   Bar-Or D, 2000, J EMERG MED, V19, P311, DOI 10.1016/S0736-4679(00)00255-9
   Bittner JG, 2012, J SURG ONCOL, V106, P557, DOI 10.1002/jso.23161
   Caglar GS, 2011, FERTIL STERIL, V95, P310, DOI 10.1016/j.fertnstert.2010.06.092
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Garrapa GGM, 2001, J CLIN ENDOCR METAB, V86, P5301, DOI 10.1210/jc.86.11.5301
   Kaefer M, 2010, CLIN BIOCHEM, V43, P450, DOI 10.1016/j.clinbiochem.2009.11.018
   Karamouzis I, 2014, CLIN ENDOCRINOL OXF
   Kazanis K, 2009, CLIN CHIM ACTA, V408, P65, DOI 10.1016/j.cca.2009.07.007
   Lippi G, 2009, ANN THORAC CARDIOVAS, V15, P137
   Nieman LK, 2008, J CLIN ENDOCR METAB, V93, P1526, DOI 10.1210/jc.2008-0125
   Nieman LK, 2010, J CLIN ENDOCR METAB, V95, P4106, DOI 10.1210/jc.2010-0457
   Paschou S, 2015, ENDOCRINE
   Prázny M, 2008, PHYSIOL RES, V57, P13, DOI 10.33549/physiolres.931126
   Tauchmanová L, 2002, J CLIN ENDOCR METAB, V87, P4872, DOI 10.1210/jc.2001-011766
   Terzolo M, 2002, J CLIN ENDOCR METAB, V87, P998, DOI 10.1210/jc.87.3.998
   Gottlieb MGV, 2010, J CLIN ENDOCR METAB, V95, P586, DOI 10.1210/jc.2009-1592
NR 17
TC 0
Z9 0
U1 0
U2 2
PU CARBONE EDITORE
PI PALERMO
PA VIA QUINTINO SELLA, 68, PALERMO, 90139, ITALY
SN 0393-6384
EI 2283-9720
J9 ACTA MEDICA MEDITERR
JI Acta Medica Mediterr.
PY 2016
VL 32
IS 2
BP 463
EP 467
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DL0QQ
UT WOS:000375338000031
DA 2025-06-11
ER

PT J
AU Milaneschi, Y
   Simonsick, EM
   Vogelzangs, N
   Strotmeyer, ES
   Yaffe, K
   Harris, TB
   Tolea, MI
   Ferrucci, L
   Penninx, BWJH
AF Milaneschi, Yuri
   Simonsick, Eleanor M.
   Vogelzangs, Nicole
   Strotmeyer, Elsa S.
   Yaffe, Kristine
   Harris, Tamara B.
   Tolea, Magdalena I.
   Ferrucci, Luigi
   Penninx, Brenda W. J. H.
CA Hlth Aging Body Composition Study
TI Leptin, Abdominal Obesity, and Onset of Depression in Older Men and
   Women
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID BODY-FAT DISTRIBUTION; C-REACTIVE PROTEIN; PLASMA LEPTIN;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; DIABETES-MELLITUS; MAJOR
   DEPRESSION; SEX-DIFFERENCES; ADIPOSE-TISSUE; SERUM LEPTIN
AB Objective: The mechanisms that underlie the association between abdominal obesity and depression risk in older persons are not well known, but the "leptin hypothesis" of depression suggests that leptin resistance may be involved in mood regulation. We tested whether high circulatory concentration of leptin, alone and in combination with visceral adiposity, is associated with onset of depression in a sample of older persons.
   Method: Participants were 1,220 men and 1,282 women aged 70-79 years and enrolled in the Health, Aging, and Body Composition study. Serum concentration of leptin and abdominal visceral fat, ascertained by computed tomography, were assessed at baseline (April 1997-June 1998). Onset of depression, the primary outcome measure, was defined as a Center for Epidemiologic Studies-Depression Scale 10-item score >= 10 and/or new antidepressant medication use at any annual visit over a 5-year follow-up.
   Results: Higher leptin level was associated with the risk of depression onset in men with high levels of visceral fat (hazard ratio [HR] =1.25; 95% CI, 1.06-1.46; P = .01) but not in those with normal visceral fat (HR = 0.98; 95% CI, 0.80-1.19; P = .80) (leptin-by-visceral fat, P = .04). No interaction between leptin and visceral fat was detected in the analysis focusing on women (P = .90).
   Conclusions: In older men, high leptin level was associated with an increased onset of depressive symptoms, especially in the presence of abdominal obesity, suggesting that underlying leptin resistance may play a role in this link. Differences in visceral fat levels and metabolic consequences may explain the absence of this association in women. These findings suggest a potential biological link between depression, obesity, and their joint association with negative health outcomes. J Clin Psychiatry 2012;73(9):1205-1211 (c) Copyright 2012 Physicians Postgraduate Press, Inc.
C1 [Milaneschi, Yuri; Vogelzangs, Nicole; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam Med Ctr, GGZ InGeest, Dept Psychiat, NL-1081 HL Amsterdam, Netherlands.
   [Milaneschi, Yuri; Simonsick, Eleanor M.; Tolea, Magdalena I.; Ferrucci, Luigi] NIA, Longitudinal Studies Sect, Clin Res Branch, Baltimore, MD 21224 USA.
   [Harris, Tamara B.] NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA.
   [Strotmeyer, Elsa S.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA.
   [Yaffe, Kristine] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA.
C3 Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; National
   Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA);
   National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; University of California System;
   University of California San Francisco
RP Milaneschi, Y (corresponding author), Vrije Univ Amsterdam Med Ctr, GGZ InGeest, Dept Psychiat, AJ Ernststr 1187, NL-1081 HL Amsterdam, Netherlands.
EM y.milaneschi@ggzingeest.nl
RI Strotmeyer, Elsa/F-3015-2014; Simonsick, Eleanor/W-6864-2019; Ferrucci,
   Luigi/AED-9724-2022; Yaffe, Kristine/LLL-8209-2024; Penninx,
   Brenda/S-7627-2017
OI Strotmeyer, Elsa/0000-0002-4093-6036; Milaneschi,
   Yuri/0000-0002-3697-6617; Ferrucci, Luigi/0000-0002-6273-1613
FU National Institute on Aging [N01-AG-6-2101, N01-AG-6-2103,
   N01-AG-6-2106]; Intramural Research Program of the National Institutes
   of Health-National Institute on Aging
FX The Health, Aging, and Body Composition (Health ABC) study is supported
   by the National Institute on Aging (N01-AG-6-2101, N01-AG-6-2103, and
   N01-AG-6-2106) and partly by the Intramural Research Program of the
   National Institutes of Health-National Institute on Aging.
CR AINSWORTH BE, 1993, MED SCI SPORT EXER, V25, P71, DOI 10.1249/00005768-199301000-00011
   ANDRESEN EM, 1994, AM J PREV MED, V10, P77, DOI 10.1016/S0749-3797(18)30622-6
   Antonijevic IA, 1998, J PSYCHIAT RES, V32, P403, DOI 10.1016/S0022-3956(98)00032-6
   Atmaca M, 2002, NEUROPSYCHOBIOLOGY, V45, P124, DOI 10.1159/000054950
   Banks WA, 2011, ENDOCRINOLOGY, V152, P2539, DOI 10.1210/en.2011-1161
   Beasley LE, 2009, OBESITY, V17, P1062, DOI 10.1038/oby.2008.627
   Bornstein SR, 2006, MOL PSYCHIATR, V11, P892, DOI 10.1038/sj.mp.4001873
   Bouret SG, 2010, BRAIN RES, V1350, P2, DOI 10.1016/j.brainres.2010.04.011
   Chen K, 2006, NAT MED, V12, P425, DOI 10.1038/nm1372
   Cushman M, 1999, CIRCULATION, V100, P717, DOI 10.1161/01.CIR.100.7.717
   Deuschle M, 1996, HORM METAB RES, V28, P714, DOI 10.1055/s-2007-979885
   Fève B, 2009, NAT REV ENDOCRINOL, V5, P305, DOI 10.1038/nrendo.2009.62
   Garza JC, 2008, J BIOL CHEM, V283, P18238, DOI 10.1074/jbc.M800053200
   Jow GM, 2006, J AFFECT DISORDERS, V90, P21, DOI 10.1016/j.jad.2005.09.015
   Kendler KS, 2005, AM J PSYCHIAT, V162, P250, DOI 10.1176/appi.ajp.162.2.250
   Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2548, DOI 10.1210/jc.2004-0395
   Koster A, 2010, OBESITY, V18, P2354, DOI 10.1038/oby.2010.86
   Kraus T, 2001, NEUROENDOCRINOLOGY, V73, P243, DOI 10.1159/000054641
   Krishnan V, 2010, AM J PSYCHIAT, V167, P1305, DOI 10.1176/appi.ajp.2009.10030434
   Lawson EA, 2012, CLIN ENDOCRINOL, V76, P520, DOI 10.1111/j.1365-2265.2011.04182.x
   Lu XY, 2007, CURR OPIN PHARMACOL, V7, P648, DOI 10.1016/j.coph.2007.10.010
   Lu XY, 2006, P NATL ACAD SCI USA, V103, P1593, DOI 10.1073/pnas.0508901103
   Ludescher B, 2007, HORM METAB RES, V39, P515, DOI 10.1055/s-2007-982518
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Maciejewski PK, 2001, PSYCHOL MED, V31, P593, DOI 10.1017/S0033291701003877
   Maraldi C, 2007, ARCH INTERN MED, V167, P1137, DOI 10.1001/archinte.167.11.1137
   Münzberg H, 2005, NAT NEUROSCI, V8, P566, DOI 10.1038/nn1454
   Myers MG, 2008, ANNU REV PHYSIOL, V70, P537, DOI 10.1146/annurev.physiol.70.113006.100707
   Oomura Y, 2006, PEPTIDES, V27, P2738, DOI 10.1016/j.peptides.2006.07.001
   PAHOR M, 1994, EUR J EPIDEMIOL, V10, P405, DOI 10.1007/BF01719664
   Paz G, 2010, INT J CLIN PRACT, V64, P1808, DOI 10.1111/j.1742-1241.2010.02536.x
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Romero-Corral A, 2008, NAT CLIN PRACT CARD, V5, P418, DOI 10.1038/ncpcardio1218
   Rubin RT, 2002, PSYCHIAT RES, V113, P255, DOI 10.1016/S0165-1781(02)00263-9
   Schwartz MW, 2005, SCIENCE, V307, P375, DOI 10.1126/science.1104344
   Shelton RC, 2010, PROG NEUROBIOL, V91, P275, DOI 10.1016/j.pneurobio.2010.04.004
   TENG EL, 1987, J CLIN PSYCHIAT, V48, P314
   Tilg H, 2006, NAT REV IMMUNOL, V6, P772, DOI 10.1038/nri1937
   Valle M, 2003, INT J OBESITY, V27, P13, DOI 10.1038/sj.ijo.0802154
   Vogelzangs N, 2010, J CLIN PSYCHIAT, V71, P391, DOI 10.4088/JCP.08m04743blu
   Volpato S, 2004, CIRCULATION, V109, P607, DOI 10.1161/01.CIR.0000109503.13955.00
   Wolk R, 2004, J AM COLL CARDIOL, V44, P1819, DOI 10.1016/j.jacc.2004.07.050
   Yamada N, 2011, ENDOCRINOLOGY, V152, P2634, DOI 10.1210/en.2011-0004
   Zeman M, 2009, NEUROENDOCRINOL LETT, V30, P387
   Zhao GX, 2011, BMC PSYCHIATRY, V11, DOI 10.1186/1471-244X-11-130
   Zupancic ML, 2011, PSYCHOSOM MED, V73, P407, DOI 10.1097/PSY.0b013e31821a196f
NR 46
TC 67
Z9 75
U1 0
U2 21
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD SEP
PY 2012
VL 73
IS 9
BP 1205
EP 1211
DI 10.4088/JCP.11m07552
PG 7
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 090SN
UT WOS:000315000400005
PM 22687702
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Tancic-Gajic, M
   Vukcevic, M
   Ivovic, M
   Marina, LV
   Arizanovic, Z
   Soldatovic, I
   Stojanovic, M
   Dogo, A
   Kendereski, A
   Vujovic, S
AF Tancic-Gajic, Milina
   Vukcevic, Miodrag
   Ivovic, Miomira
   Marina, Ljiljana V.
   Arizanovic, Zorana
   Soldatovic, Ivan
   Stojanovic, Milos
   Dogo, Aleksandar
   Kendereski, Aleksandra
   Vujovic, Svetlana
TI Obstructive Sleep Apnea Is Associated With Low Testosterone Levels in
   Severely Obese Men
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE obesity; metabolic syndrome; sleep apnea; testosterone; male
ID POSITIVE AIRWAY PRESSURE; METABOLIC SYNDROME; ERECTILE DYSFUNCTION;
   OXYGEN DESATURATION; BODY-WEIGHT; HYPOXIA; DEPRESSION; ENDOCRINE;
   IMPOTENCE; EFFICACY
AB Background Disrupted sleep affects cardio-metabolic and reproductive health. Obstructive sleep apnea syndrome represents a major complication of obesity and has been associated with gonadal axis activity changes and lower serum testosterone concentration in men. However, there is no consistent opinion on the effect of obstructive sleep apnea on testosterone levels in men. Objective The aim of this study was to determine the influence of obstructive sleep apnea on total and free testosterone levels in severely obese men. Materials and methods The study included 104 severely obese (Body Mass Index (BMI) >= 35 kg/m(2)) men, aged 20 to 60, who underwent anthropometric, blood pressure, fasting plasma glucose, lipid profile, and sex hormone measurements. All participants were subjected to polysomnography. According to apnea-hypopnea index (AHI) patients were divided into 3 groups: <15 (n = 20), 15 - 29.9 (n = 17) and >= 30 (n = 67). Results There was a significant difference between AHI groups in age (29.1 +/- 7.2, 43.2 +/- 13.2, 45.2 +/- 10.2 years; p < 0.001), BMI (42.8 +/- 5.9, 43.2 +/- 5.9, 47.1 +/- 7.8 kg/m(2); p = 0.023), the prevalence of metabolic syndrome (MetS) (55%, 82.4%, 83.6%, p = 0.017), continuous metabolic syndrome score (siMS) (4.01 +/- 1.21, 3.42 +/- 0.80, 3.94 +/- 1.81, 4.20 +/- 1.07; p = 0.038), total testosterone (TT) (16.6 +/- 6.1, 15.2 +/- 5.3, 11.3 +/- 4.44 nmol/l; p < 0.001) and free testosterone (FT) levels (440.4 +/- 160.8, 389.6 +/- 162.5, 294.5 +/- 107.0 pmol/l; p < 0.001). TT level was in a significant negative correlation with AHI, oxygen desaturation index (ODI), BMI, MetS and siMS. Also, FT was in a significant negative correlation with AHI, ODI, BMI, age, MetS and siMS. The multiple regression analysis revealed that both AHI and ODI were in significant correlation with TT and FT after adjustment for age, BMI, siMS score and MetS components. Conclusion Obstructive sleep apnea is associated with low TT and FT levels in severely obese men.
C1 [Tancic-Gajic, Milina; Ivovic, Miomira; Marina, Ljiljana V.; Arizanovic, Zorana; Stojanovic, Milos; Kendereski, Aleksandra; Vujovic, Svetlana] Univ Belgrade, Fac Med, Clin Endocrinol Diabet & Metab Dis, Univ Clin Ctr Serbia,Dept Obes Reprod & Metab Dis, Belgrade, Serbia.
   [Vukcevic, Miodrag] Univ Belgrade, Dept Pulmonol, Clin Hosp Ctr Zemun, Fac Med, Belgrade, Serbia.
   [Soldatovic, Ivan] Univ Belgrade, Fac Med, Inst Med Stat & Informat, Belgrade, Serbia.
   [Dogo, Aleksandar] Clin Ctr Montenegro, Dept Endocrinol, Podgorica, Montenegro.
C3 University of Belgrade; Clinical Centre of Serbia; University of
   Belgrade; University of Belgrade
RP Marina, LV (corresponding author), Univ Belgrade, Fac Med, Clin Endocrinol Diabet & Metab Dis, Univ Clin Ctr Serbia,Dept Obes Reprod & Metab Dis, Belgrade, Serbia.
EM ljilja.marina@gmail.com
RI Ivovic, Miomira/ABE-8298-2021; Marina, Ljiljana/AAH-1185-2019
OI Marina, Ljiljana/0000-0003-2664-3664; Vukcevic,
   Miodrag/0000-0002-6218-3848; Tancic-Gajic, Milina/0000-0001-7290-5181
CR Barrett-Connor E, 2008, J CLIN ENDOCR METAB, V93, P2602, DOI 10.1210/jc.2007-2622
   Berry RB, 2012, J CLIN SLEEP MED, V8, P597, DOI 10.5664/jcsm.2172
   Bhasin S, 2018, J CLIN ENDOCR METAB, V103, P1715, DOI 10.1210/jc.2018-00229
   Brand JS, 2011, INT J EPIDEMIOL, V40, P189, DOI 10.1093/ije/dyq158
   Canguven Onder, 2010, Arch Ital Urol Androl, V82, P143
   Cho YM, 2019, LIFE SCI, V233, DOI 10.1016/j.lfs.2019.116694
   Chourdakis M, 2020, CLIN NUTR ESPEN, V39, P1, DOI 10.1016/j.clnesp.2020.07.012
   Cignarelli A, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00551
   Clarke BM, 2020, EUR J ENDOCRINOL, V183, P31, DOI 10.1530/EJE-19-0978
   Corona G, 2015, MOL CELL ENDOCRINOL, V418, P120, DOI 10.1016/j.mce.2015.06.031
   Corona G, 2013, EUR J ENDOCRINOL, V168, P829, DOI 10.1530/EJE-12-0955
   Corona G, 2011, J SEX MED, V8, P272, DOI 10.1111/j.1743-6109.2010.01991.x
   Crisóstomo L, 2020, MOL CELL ENDOCRINOL, V516, DOI 10.1016/j.mce.2020.110945
   Fernandez Cornelius J, 2019, Eur Endocrinol, V15, P83, DOI 10.17925/EE.2019.15.2.83
   Flemons WW, 1999, SLEEP, V22, P667, DOI 10.1093/sleep/22.5.667
   Gambineri A, 2003, J ENDOCRINOL INVEST, V26, P493, DOI 10.1007/BF03345209
   Gautier A, 2013, CLIN ENDOCRINOL, V78, P373, DOI 10.1111/j.1365-2265.2012.04401.x
   Gottlieb DJ, 2020, JAMA-J AM MED ASSOC, V323, P1389, DOI 10.1001/jama.2020.3514
   Grossmann M, 2020, ANDROLOGY-US, V8, P1519, DOI 10.1111/andr.12705
   GRUNSTEIN RR, 1989, J CLIN ENDOCR METAB, V68, P352, DOI 10.1210/jcem-68-2-352
   Hammoud AO, 2012, ASIAN J ANDROL, V14, P77, DOI 10.1038/aja.2011.64
   Hammoud AO, 2011, OBESITY, V19, P1118, DOI 10.1038/oby.2010.344
   Kip KE, 2004, CIRCULATION, V109, P706, DOI 10.1161/01.CIR.0000115514.44135.A8
   Kirbas G, 2007, J INT MED RES, V35, P38, DOI 10.1177/147323000703500103
   KOUCHIYAMA S, 1990, RESPIRATION, V57, P359
   Lam B, 2005, THORAX, V60, P504, DOI 10.1136/thx.2004.031591
   Lanfranco F, 2010, INT J ENDOCRINOL, V2010, DOI 10.1155/2010/474518
   Li ZJ, 2016, RESP MED, V119, P130, DOI 10.1016/j.rmed.2016.09.001
   Liu GL, 2012, J BIOMED SCI, V19, DOI 10.1186/1423-0127-19-4
   Liu PY, 2019, J CLIN ENDOCR METAB, V104, P4398, DOI 10.1210/jc.2019-00683
   Luboshitzky R, 2003, NEUROENDOCRINOL LETT, V24, P463
   Luboshitzky R, 2002, J CLIN ENDOCR METAB, V87, P3394, DOI 10.1210/jc.87.7.3394
   Luboshitzky R, 2001, J CLIN ENDOCR METAB, V86, P1134, DOI 10.1210/jc.86.3.1134
   Mah PM, 2010, MOL CELL ENDOCRINOL, V316, P180, DOI 10.1016/j.mce.2009.06.007
   McNicholas WT, 2019, EXPERT REV RESP MED, V13, P251, DOI 10.1080/17476348.2019.1575204
   Meston N, 2003, J INTERN MED, V254, P447, DOI 10.1046/j.1365-2796.2003.01212.x
   Molina-Vega M, 2019, OBESITY, V27, P1584, DOI 10.1002/oby.22579
   Piliar G, 2008, DIABETES CARE, V31, pS303, DOI 10.2337/dc08-s272
   SANTAMARIA JD, 1988, CLIN ENDOCRINOL, V28, P461, DOI 10.1111/j.1365-2265.1988.tb03680.x
   SEMPLE PD, 1984, THORAX, V39, P46, DOI 10.1136/thx.39.1.46
   SEMPLE PD, 1984, BRIT MED J, V289, P801, DOI 10.1136/bmj.289.6448.801
   SEMPLE PD, 1983, THORAX, V38, P45, DOI 10.1136/thx.38.1.45
   Semple PD., 1980, BR J SEX MED, V7, P48
   SEMPLE PDA, 1980, CLIN SCI, V58, P105, DOI 10.1042/cs0580105
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Soldatovic I, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0146143
   Soukhova-O'Hare GK, 2008, AM J RESP CRIT CARE, V178, P644, DOI 10.1164/rccm.200801-190OC
   Sultan S, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00408
   Tancic-Gajic M, 2012, HIPPOKRATIA, V16, P335
   Travison TG, 2007, J CLIN ENDOCR METAB, V92, P549, DOI 10.1210/jc.2006-1859
   Vermeulen A, 1999, J CLIN ENDOCR METAB, V84, P3666, DOI 10.1210/jc.84.10.3666
   Wilson EN, 2018, PHYSIOL BEHAV, V189, P64, DOI 10.1016/j.physbeh.2018.03.007
   Xanthopoulos MS, 2018, METABOLISM, V84, P109, DOI 10.1016/j.metabol.2018.01.022
   Zhang XB, 2016, ARCH SEX BEHAV, V45, P235, DOI 10.1007/s10508-015-0593-2
NR 54
TC 5
Z9 5
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JUL 26
PY 2021
VL 12
AR 622496
DI 10.3389/fendo.2021.622496
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA TX2FL
UT WOS:000682905800001
PM 34381420
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hewlings, SJ
   Kalman, DS
AF Hewlings, Susan J.
   Kalman, Douglas S.
TI Curcumin: A Review of Its Effects on Human Health
SO FOODS
LA English
DT Review
DE curcumin; turmeric; antioxidant; anti-inflammatory; polyphenol
ID METABOLIC SYNDROME; ANTIINFLAMMATORY PROPERTIES; PIPERINE COMBINATION;
   KNEE OSTEOARTHRITIS; OBESE INDIVIDUALS; DELIVERY-SYSTEM; MUSCLE DAMAGE;
   DOUBLE-BLIND; ANTIOXIDANT; EFFICACY
AB Turmeric, a spice that has long been recognized for its medicinal properties, has received interest from both the medical/scientific world and from culinary enthusiasts, as it is the major source of the polyphenol curcumin. It aids in the management of oxidative and inflammatory conditions, metabolic syndrome, arthritis, anxiety, and hyperlipidemia. It may also help in the management of exercise-induced inflammation and muscle soreness, thus enhancing recovery and performance in active people. In addition, a relatively low dose of the complex can provide health benefits for people that do not have diagnosed health conditions. Most of these benefits can be attributed to its antioxidant and anti-inflammatory effects. Ingesting curcumin by itself does not lead to the associated health benefits due to its poor bioavailability, which appears to be primarily due to poor absorption, rapid metabolism, and rapid elimination. There are several components that can increase bioavailability. For example, piperine is the major active component of black pepper and, when combined in a complex with curcumin, has been shown to increase bioavailability by 2000%. Curcumin combined with enhancing agents provides multiple health benefits. The purpose of this review is to provide a brief overview of the plethora of research regarding the health benefits of curcumin.
C1 [Hewlings, Susan J.] Cent Michigan Univ, Dept Nutr, Mt Pleasant, MI 48859 USA.
   [Hewlings, Susan J.] Substantiat Sci, Weston, FL 33332 USA.
   [Kalman, Douglas S.] Nova Southeastern Univ, Hlth & Human Performance, Ft Lauderdale, FL 33314 USA.
   [Kalman, Douglas S.] QPS, Nutr Res Div, Miami, FL 33143 USA.
C3 Central Michigan University; Nova Southeastern University
RP Hewlings, SJ (corresponding author), Cent Michigan Univ, Dept Nutr, Mt Pleasant, MI 48859 USA.; Hewlings, SJ (corresponding author), Substantiat Sci, Weston, FL 33332 USA.
EM sue.hewlings@gmail.com; dougkalman@gmail.com
OI Hewlings, Susan/0000-0001-8540-2591
CR Aggarwal BB, 2003, ANTICANCER RES, V23, P363
   Aggarwal BB, 2009, INT J BIOCHEM CELL B, V41, P40, DOI 10.1016/j.biocel.2008.06.010
   Ak T, 2008, CHEM-BIOL INTERACT, V174, P27, DOI 10.1016/j.cbi.2008.05.003
   Allegri P, 2010, CLIN OPHTHALMOL, V4, P1201, DOI 10.2147/OPTH.S13271
   Anand P, 2007, MOL PHARMACEUT, V4, P807, DOI 10.1021/mp700113r
   Banach M, 2014, INT UROL NEPHROL, V46, P947, DOI 10.1007/s11255-014-0657-6
   Basnet P, 2011, MOLECULES, V16, P4567, DOI 10.3390/molecules16064567
   Belcaro G, 2010, PANMINERVA MED, V52, P269
   Belcaro G, 2014, PHYTOTHER RES, V28, P444, DOI 10.1002/ptr.5014
   Biswas SK, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/5698931
   Bradford PG, 2013, BIOFACTORS, V39, P78, DOI 10.1002/biof.1074
   Chandran B, 2012, PHYTOTHER RES, V26, P1719, DOI 10.1002/ptr.4639
   Chilelli NC, 2016, NUTRIENTS, V8, DOI 10.3390/nu8110745
   Chuengsamarn S, 2012, DIABETES CARE, V35, P2121, DOI 10.2337/dc12-0116
   Cox KHM, 2015, J PSYCHOPHARMACOL, V29, P642, DOI 10.1177/0269881114552744
   Daily JW, 2016, J MED FOOD, V19, P717
   Delecroix B, 2017, J SPORT SCI MED, V16, P147
   Di Pierro F, 2013, J PAIN RES, V6, P201, DOI 10.2147/JPR.S42184
   DiSilvestro RA, 2012, NUTR J, V11, DOI 10.1186/1475-2891-11-79
   Drobnic F, 2014, J INT SOC SPORT NUTR, V11, DOI 10.1186/1550-2783-11-31
   Epstein J, 2010, BRIT J NUTR, V103, P1545, DOI 10.1017/S0007114509993667
   Esmaily H, 2015, CHIN J INTEGR MED, V21, P332, DOI 10.1007/s11655-015-2160-z
   Ganjali S, 2014, SCI WORLD J, DOI 10.1155/2014/898361
   Goldring M B, 2000, Curr Rheumatol Rep, V2, P459, DOI 10.1007/s11926-000-0021-y
   Gupta SC, 2013, AAPS J, V15, P195, DOI 10.1208/s12248-012-9432-8
   Han HK, 2011, EXPERT OPIN DRUG MET, V7, P721, DOI 10.1517/17425255.2011.570332
   Henrotin Y, 2013, SPRINGERPLUS, V2, DOI 10.1186/2193-1801-2-56
   Hlavacková L, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-72
   Hunter DJ, 2014, NAT REV RHEUMATOL, V10, P437, DOI 10.1038/nrrheum.2014.44
   Jurenka JS, 2009, ALTERN MED REV, V14, P141
   Kocaadam B, 2017, CRIT REV FOOD SCI, V57, P2889, DOI 10.1080/10408398.2015.1077195
   Kunnumakkara AB, 2017, CLIN SCI, V131, P1781, DOI 10.1042/CS20160935
   Kuptniratsaikul V, 2014, CLIN INTERV AGING, V9, P451, DOI 10.2147/CIA.S58535
   Lao Christopher D, 2006, BMC Complement Altern Med, V6, P10, DOI 10.1186/1472-6882-6-10
   Lestari Maria L A D, 2014, Profiles Drug Subst Excip Relat Methodol, V39, P113, DOI 10.1016/B978-0-12-800173-8.00003-9
   Lin YG, 2007, CLIN CANCER RES, V13, P3423, DOI 10.1158/1078-0432.CCR-06-3072
   Mahady GB, 2002, ANTICANCER RES, V22, P4179
   Marchiani A, 2014, CURR MED CHEM, V21, P204
   Mazzolani F, 2013, CLIN OPHTHALMOL, V7, P939, DOI 10.2147/OPTH.S45820
   McFarlin BK, 2016, BBA CLIN, V5, P72, DOI 10.1016/j.bbacli.2016.02.003
   Menon VP, 2007, ADV EXP MED BIOL, V595, P105
   Mohammadi A, 2013, PHYTOTHER RES, V27, P374, DOI 10.1002/ptr.4715
   Na LX, 2013, MOL NUTR FOOD RES, V57, P1569, DOI 10.1002/mnfr.201200131
   Panahi Y, 2016, BIOMED PHARMACOTHER, V82, P578, DOI 10.1016/j.biopha.2016.05.037
   Panahi Y, 2015, CLIN NUTR, V34, P1101, DOI 10.1016/j.clnu.2014.12.019
   Panahi Yunes, 2016, Journal of Dietary Supplements, V13, P209, DOI 10.3109/19390211.2015.1008611
   Panahi Y, 2014, COMPLEMENT THER MED, V22, P851, DOI 10.1016/j.ctim.2014.07.006
   Panahi Y, 2014, PHYTOTHER RES, V28, P1625, DOI 10.1002/ptr.5174
   Priyadarsini KI, 2014, MOLECULES, V19, P20091, DOI 10.3390/molecules191220091
   Priyadarsini KI, 2003, FREE RADICAL BIO MED, V35, P475, DOI 10.1016/S0891-5849(03)00325-3
   Rahimnia AR, 2015, DRUG RES, V65, P521, DOI 10.1055/s-0034-1384536
   Recio MC, 2012, CURR MED CHEM, V19, P2088
   Reddy RC, 2005, BIOCHEM BIOPH RES CO, V326, P472, DOI 10.1016/j.bbrc.2004.11.051
   Sahebkar A, 2015, J FUNCT FOODS, V18, P898, DOI 10.1016/j.jff.2015.01.005
   Sahebkar A, 2014, PHYTOTHER RES, V28, P633, DOI 10.1002/ptr.5045
   Sahebkar A, 2014, NAT REV CARDIOL, V11, P12, DOI 10.1038/nrcardio.2013.139-c1
   Sahebkar A, 2013, PHYTOTHER RES, V27, P1883, DOI 10.1002/ptr.4952
   Sahebkar A, 2010, FERTIL STERIL, V94, pE75, DOI 10.1016/j.fertnstert.2010.07.1071
   Sharma RA, 2004, CLIN CANCER RES, V10, P6847, DOI 10.1158/1078-0432.CCR-04-0744
   Shoba G, 1998, PLANTA MED, V64, P353, DOI 10.1055/s-2006-957450
   Soni K. B., 1992, Indian Journal of Physiology and Pharmacology, V36, P273
   Strimpakos AS, 2008, ANTIOXID REDOX SIGN, V10, P511, DOI 10.1089/ars.2007.1769
   Trujillo J, 2013, REDOX BIOL, V1, P448, DOI 10.1016/j.redox.2013.09.003
   Vera-Ramirez L, 2013, BIOFACTORS, V39, P88, DOI 10.1002/biof.1057
   Vos T, 2015, LANCET, V386, P743, DOI 10.1016/S0140-6736(15)60692-4
   Wright LE, 2013, CURR PHARM DESIGN, V19, P6218, DOI 10.2174/1381612811319340013
NR 66
TC 1610
Z9 1699
U1 36
U2 331
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD OCT
PY 2017
VL 6
IS 10
AR 92
DI 10.3390/foods6100092
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA FL9PZ
UT WOS:000414590300009
PM 29065496
OA Green Published, gold, Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Li, SP
   Zeng, XY
   Zhou, X
   Wang, H
   Ja, EJ
   Robinson, SR
   Xu, AM
   Ye, JM
AF Li, Songpei
   Zeng, Xiao-Yi
   Zhou, Xiu
   Wang, Hao
   Ja, Eunjung
   Robinson, Stephen R.
   Xu, Aimin
   Ye, Ji-Ming
TI Dietary cholesterol induces hepatic inflammation and blunts
   mitochondrial function in the liver of high-fat-fed mice
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Dietary cholesterol; High fat diet; Inflammation; Mitochondrial
   function; Nonalcoholic fatty liver disease
ID INDUCED INSULIN-RESISTANCE; NONALCOHOLIC-STEATOHEPATITIS; OXIDATIVE
   STRESS; DIABETIC-RETINOPATHY; METABOLIC SYNDROME; SKELETAL-MUSCLE;
   PROTEIN-KINASE; FED RATS; DISEASE; OBESITY
AB The present study investigated the role of dietary cholesterol and fat in the development of nonalcoholic fatty liver disease, a common liver disease in metabolic disorders. Mice were fed a diet of regular chow (CH), chow supplemented with 0.2% w/w cholesterol (CHC), high fat (HF, 45 kcal%) or HF with cholesterol (HFC) for 17 weeks. While both HF and HFC groups displayed hepatic steatosis and metabolic syndrome, only HFC group developed the phenotype of liver injury, as indicated by an increase in plasma level of alanine transaminase (ALT, by 50-80%). There were similar to 2-fold increases in mRNA expression of tumor necrosis factor et, interleukin 113 and monocyte chemotactic protein 1 in the liver of HFC-fed mice (vs. HF) but no endoplasmic reticulum stress or oxidative stress was observed. Furthermore, cholesterol suppressed HF-induced increase of peroxisome proliferator-activated receptor gamma coactivator lot and mitochondrial transcription factor A expression and blunted fatty acid oxidation. Interestingly, after switching HFC to HF diet for 5 weeks, the increases in plasma ALT and liver inflammatory markers were abolished but the blunted of mitochondrial function remained. These findings suggest that cholesterol plays a critical role in the conversion of a simple fatty liver toward nonalcoholic steatohepatitis possibly by activation of inflammatory pathways together with retarded mitochondria( function. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Li, Songpei; Zeng, Xiao-Yi; Zhou, Xiu; Wang, Hao; Ja, Eunjung; Robinson, Stephen R.; Ye, Ji-Ming] RMIT Univ, Hlth Innovat Res Inst, Melbourne, Vic 3083, Australia.
   [Li, Songpei; Zeng, Xiao-Yi; Zhou, Xiu; Wang, Hao; Ja, Eunjung; Robinson, Stephen R.; Ye, Ji-Ming] RMIT Univ, Sch Hlth Sci, Melbourne, Vic 3083, Australia.
   [Xu, Aimin] Univ Hong Kong, State Key Lab Pharmaceut Biotechnol, Hong Kong, Hong Kong, Peoples R China.
   [Xu, Aimin] Univ Hong Kong, Dept Med, Hong Kong, Hong Kong, Peoples R China.
C3 Royal Melbourne Institute of Technology (RMIT); Royal Melbourne
   Institute of Technology (RMIT); University of Hong Kong; University of
   Hong Kong
RP Ye, JM (corresponding author), RMIT Univ, Lipid Biol & Metab Dis, Hlth Innovat Res Inst, Bldg 202,Level 4,POB 71, Melbourne, Vic 3083, Australia.
EM jiming.ye@rmit.edu.au
RI Robinson, Stephen/AAU-3219-2021; xu, aimin/K-4332-2019; ZHOU,
   XIU/AAX-5312-2020; Wang, Hao/AFK-7816-2022
OI Wang, Hao/0000-0002-0901-5183; Robinson, Stephen/0000-0002-0987-0075
FU National Health and Medical Research Council of Australia [535921]
FX The authors would like to acknowledge Dr. Suzanne Rogers (RMIT
   University) for her critique of this manuscript. This study was
   supported by the National Health and Medical Research Council of
   Australia Program Grant 535921 (allocation to JMY).
CR Arruda AP, 2014, NAT MED, V20, P1427, DOI 10.1038/nm.3735
   Austin S, 2012, J CELL SCI, V125, P4963, DOI 10.1242/jcs.113662
   Begriche K, 2013, HEPATOLOGY, V58, P1497, DOI 10.1002/hep.26226
   Berglund L, 2003, ARTERIOSCL THROM VAS, V23, P1314, DOI 10.1161/01.ATV.0000087145.71160.15
   BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911
   Bonnard C, 2008, J CLIN INVEST, V118, P789, DOI 10.1172/JCI32601
   Braunersreuther V, 2012, WORLD J GASTROENTERO, V18, P727, DOI 10.3748/wjg.v18.i8.727
   BROWN MS, 1983, ANNU REV BIOCHEM, V52, P223, DOI 10.1146/annurev.bi.52.070183.001255
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cantley JL, 2013, P NATL ACAD SCI USA, V110, P1869, DOI 10.1073/pnas.1219456110
   Chan SMH, 2015, BBA-MOL BASIS DIS, V1852, P1511, DOI 10.1016/j.bbadis.2015.04.005
   Chan SMH, 2013, DIABETES, V62, P2095, DOI 10.2337/db12-1397
   Cohen JC, 2011, SCIENCE, V332, P1519, DOI 10.1126/science.1204265
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   Ellegard L, 2000, EUR J CLIN NUTR, V54, P306, DOI 10.1038/sj.ejcn.1600940
   Erion DM, 2010, NAT MED, V16, P400, DOI 10.1038/nm0410-400
   Frangioudakis G, 2005, ENDOCRINOLOGY, V146, P5596, DOI 10.1210/en.2005-0481
   Gan LT, 2014, J HEPATOL, V61, P1376, DOI 10.1016/j.jhep.2014.07.024
   Hunter RL, 2007, J NEUROCHEM, V100, P1375, DOI 10.1111/j.1471-4159.2006.04327.x
   LaBrecque DR, 2014, J CLIN GASTROENTEROL, V48, P467, DOI 10.1097/MCG.0000000000000116
   Lalor PF, 2007, SEMIN LIVER DIS, V27, P173, DOI 10.1055/s-2007-979470
   Landau JM, 1997, BBA-LIPID LIPID MET, V1345, P349, DOI 10.1016/S0005-2760(97)00010-6
   Lee YS, 2011, DIABETES, V60, P2474, DOI 10.2337/db11-0194
   Madsen-Bouterse SA, 2010, ANTIOXID REDOX SIGN, V13, P797, DOI 10.1089/ars.2009.2932
   Malhi H, 2011, J HEPATOL, V54, P795, DOI 10.1016/j.jhep.2010.11.005
   Mells JE, 2015, J NUTR BIOCHEM, V26, P285, DOI 10.1016/j.jnutbio.2014.11.002
   Musso G, 2003, HEPATOLOGY, V37, P909, DOI 10.1053/jhep.2003.50132
   Ouadda ABD, 2009, BIOSCIENCE REP, V29, P283, DOI 10.1042/BSR20080141
   Ouyang X, 2008, J HEPATOL, V48, P993, DOI 10.1016/j.jhep.2008.02.011
   Pickersgill L, 2007, J BIOL CHEM, V282, P12583, DOI 10.1074/jbc.M611157200
   Pinnamaneni SK, 2006, DIABETOLOGIA, V49, P3027, DOI 10.1007/s00125-006-0427-9
   Ren LP, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030816
   Ros E, 2000, ATHEROSCLEROSIS, V151, P357, DOI 10.1016/S0021-9150(00)00456-1
   Rose S, 2014, TRANSL PSYCHIAT, V4, DOI 10.1038/tp.2014.15
   Santos JM, 2013, DIABETES-METAB RES, V29, P204, DOI 10.1002/dmrr.2384
   Stanton MC, 2011, J INFLAMM-LOND, V8, DOI 10.1186/1476-9255-8-8
   Steinberg GR, 2003, AM J PHYSIOL-ENDOC M, V284, pE648, DOI 10.1152/ajpendo.00318.2002
   Summers SA, 2010, CURR OPIN LIPIDOL, V21, P128, DOI 10.1097/MOL.0b013e3283373b66
   Sun Y, 2009, CIRC RES, V104, P455, DOI 10.1161/CIRCRESAHA.108.182568
   Takaki A, 2013, INT J MOL SCI, V14, P20704, DOI 10.3390/ijms141020704
   Teng KT, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-12
   Tilg H, 2008, TRENDS ENDOCRIN MET, V19, P371, DOI 10.1016/j.tem.2008.08.005
   Turner N, 2007, DIABETES, V56, P2085, DOI 10.2337/db07-0093
   Turner N, 2009, DIABETES, V58, P2547, DOI 10.2337/db09-0784
   Vannuvel K, 2013, J CELL PHYSIOL, V228, P1802, DOI 10.1002/jcp.24360
   Videla LA, 2006, TRENDS MOL MED, V12, P555, DOI 10.1016/j.molmed.2006.10.001
   Woo SL, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0091111
   Wouters K, 2008, HEPATOLOGY, V48, P474, DOI 10.1002/hep.22363
   Wu ZD, 1999, CELL, V98, P115, DOI 10.1016/S0092-8674(00)80611-X
   Ye DW, 2012, GUT, V61, P1058, DOI 10.1136/gutjnl-2011-300269
   Ye JM, 2011, BRIT J PHARMACOL, V163, P556, DOI 10.1111/j.1476-5381.2011.01240.x
   Ye JM, 2003, AM J PHYSIOL-ENDOC M, V284, pE531, DOI 10.1152/ajpendo.00299.2002
   Zeng XY, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0042115
   Zheng Y, 2013, IMMUNITY, V38, P285, DOI 10.1016/j.immuni.2013.01.008
   Zhou RB, 2011, NATURE, V469, P221, DOI 10.1038/nature09663
   Zhuang YB, 2014, J BIOL CHEM, V289, P25101, DOI 10.1074/jbc.M114.578260
   Zorov DB, 2014, PHYSIOL REV, V94, P909, DOI 10.1152/physrev.00026.2013
NR 57
TC 26
Z9 26
U1 1
U2 23
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD JAN
PY 2016
VL 27
BP 96
EP 103
DI 10.1016/j.jnutbio.2015.08.021
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA CZ9HX
UT WOS:000367409800011
PM 26391864
DA 2025-06-11
ER

PT J
AU Selenius, JS
   Wasenius, NS
   Kautiainen, H
   Salonen, M
   von Bonsdorff, M
   Eriksson, JG
AF Selenius, Jannica S.
   Wasenius, Niko S.
   Kautiainen, Hannu
   Salonen, Minna
   von Bonsdorff, Mikaela
   Eriksson, Johan G.
TI Impaired glucose regulation, depressive symptoms, and health-related
   quality of life
SO BMJ OPEN DIABETES RESEARCH & CARE
LA English
DT Article
ID METABOLIC SYNDROME; DIABETES-MELLITUS; PSYCHOMETRIC PROPERTIES;
   INVENTORY-II; POPULATION; PREVALENCE; RISK; COMPLICATIONS; ASSOCIATION
AB Introduction This study aims to investigate whether the associations between impaired glucose regulation and health-related quality of life are modified by severity or type of depressive symptoms.
   Research design and methods For this cross-sectional study, we included 1939 individuals (mean age 61.5 years) from the Helsinki Birth Cohort Study. Between 2001 and 2004, a standard 2-hour 75 g oral glucose tolerance test was applied to define normoglycemia, pre-diabetes, and newly diagnosed diabetes. Information on previously diagnosed diabetes was collected from national registers and questionnaires. Pre-diabetes was defined as having either impaired fasting glucose or impaired glucose tolerance. The Mental and Physical Component Scores of health-related quality of life were assessed with Short Form-36. Beck's Depression Inventory was employed to investigate the severity of depressive symptoms and to define minimal (depression score <10), non-melancholic, and melancholic types of depression. We analyzed data with general linear models adjusted for sex, age, lifestyle factors, comorbidities, and body mass index.
   Results Glucose regulation subgroups, especially previously known diabetes, were associated with lower Physical Component Score (p=0.001) and higher depression score (p=0.015), but not with the Mental Component Score (p=0.189). Non-melancholic depression was associated with lower Physical and Mental Component Scores compared with those with depression score <10 and melancholic depression (p<0.001), independently of glucose regulation status (p for glucose regulation status by depression type interaction >0.54).
   Conclusions Non-melancholic type of depression and previously known diabetes are independently associated with lower health-related quality of life. This should be appraised in long-term treatment of diabetes and when treating non-melancholic depressive symptoms to maintain a higher health-related quality of life.
C1 [Selenius, Jannica S.; Wasenius, Niko S.; Kautiainen, Hannu; Eriksson, Johan G.] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.
   [Selenius, Jannica S.; Wasenius, Niko S.; Salonen, Minna; von Bonsdorff, Mikaela; Eriksson, Johan G.] Folkhalsan Res Ctr, Publ Hlth Res Porgramme, Helsinki, Finland.
   [Salonen, Minna] Natl Publ Hlth Inst, Dept Epidemiol & Hlth Promot, Helsinki, Finland.
   [von Bonsdorff, Mikaela] Univ Jyvaskyla, Gerontol Res Ctr, Jyvaskyla, Finland.
   [von Bonsdorff, Mikaela] Univ Jyvaskyla, Fac Sport & Hlth Sci, Jyvaskyla, Finland.
   [Eriksson, Johan G.] ASTAR, Singapore Inst Clin Sci SICS, Singapore, Singapore.
   [Eriksson, Johan G.] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Obstet & Gynecol, Singapore, Singapore.
C3 University of Helsinki; Folkhalsan Research Center; Finland National
   Institute for Health & Welfare; University of Jyvaskyla; University of
   Jyvaskyla; Agency for Science Technology & Research (A*STAR); A*STAR -
   Singapore Institute for Clinical Sciences (SICS); National University of
   Singapore
RP Selenius, JS (corresponding author), Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.; Selenius, JS (corresponding author), Folkhalsan Res Ctr, Publ Hlth Res Porgramme, Helsinki, Finland.
EM jannica.selenius@helsinki.fi
RI Gibbs, J. Raphael/A-3984-2010; Wasenius, Niko/AAE-8927-2020; von
   Bonsdorff, Mikaela/A-5218-2015
OI Wasenius, Niko/0000-0002-9007-6660; Eriksson, Johan/0000-0002-2516-2060;
   Selenius, Jannica/0000-0002-4336-8580; von Bonsdorff,
   Mikaela/0000-0001-8530-5230
FU Finnish Foundation for Cardiovascular Research; Finnish Foundation for
   Diabetes Research; Juho Vainio Foundation; Academy of Finland; Novo
   Nordisk Foundation; Signe and Ane Gyllenberg Foundation; Samfundet
   Folkhalsan; Finska Lakaresallskapet; Liv och Halsa; European Commission
   FP7 (DORIAN) [278 603]; EU H2020-PHC2014-DynaHealth [633 595]; EU
   Horizon 2020 Award [733 206 LIFECYCLE]
FX HBCS was supported by Finnish Foundation for Cardiovascular Research,
   Finnish Foundation for Diabetes Research, Juho Vainio Foundation,
   Academy of Finland, Novo Nordisk Foundation, Signe and Ane Gyllenberg
   Foundation, Samfundet Folkhalsan, Finska Lakaresallskapet, Liv och
   Halsa, European Commission FP7 (DORIAN) Grant Agreement No 278 603 and
   EU H2020-PHC2014-DynaHealth Grant No 633 595 and EU Horizon 2020 Award
   733 206 LIFECYCLE.
CR Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Ali S, 2006, DIABETIC MED, V23, P1165, DOI 10.1111/j.1464-5491.2006.01943.x
   Aro A.R., 1999, TUTKIMUKSIA, V101
   Aujla N, 2010, DIABETIC MED, V27, P896, DOI 10.1111/j.1464-5491.2010.03042.x
   Aujla N, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007755
   BECK AT, 1988, CLIN PSYCHOL REV, V8, P77, DOI 10.1016/0272-7358(88)90050-5
   Central Statstical Office of Finland Classification of Socio-economic Group, 1989, CENTR STATST OFF FIN
   Cho NH, 2018, DIABETES RES CLIN PR, V138, P271, DOI 10.1016/j.diabres.2018.02.023
   Eaton WW, 1996, DIABETES CARE, V19, P1097, DOI 10.2337/diacare.19.10.1097
   Engum A, 2005, DIABETES CARE, V28, P1904, DOI 10.2337/diacare.28.8.1904
   Eriksson JG, 2015, J INTERN MED, V278, P219, DOI 10.1111/joim.12354
   Ghorbani A, 2014, DIABETIC MED, V31, P754, DOI 10.1111/dme.12415
   Hunger M, 2014, QUAL LIFE RES, V23, P2515, DOI 10.1007/s11136-014-0689-5
   Icks A, 2008, DIABETIC MED, V25, P1330, DOI 10.1111/j.1464-5491.2008.02585.x
   Korniloff K, 2017, PAIN MED, V18, P341, DOI 10.1093/pm/pnw202
   LAKKA TA, 1994, NEW ENGL J MED, V330, P1549, DOI 10.1056/NEJM199406023302201
   Lamers F, 2013, MOL PSYCHIATR, V18, P692, DOI 10.1038/mp.2012.144
   Lamers F, 2010, J CLIN PSYCHIAT, V71, P1582, DOI 10.4088/JCP.09m05398blu
   Silva NDLE, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00057
   Neumann A, 2014, HEALTH QUAL LIFE OUT, V12, DOI 10.1186/s12955-014-0150-z
   Organization W.H., 2017, Depression and other common mental disorders: Global health estimates
   Penninx BWJH, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-129
   Rubin RR, 1999, DIABETES-METAB RES, V15, P205, DOI 10.1002/(SICI)1520-7560(199905/06)15:3<205::AID-DMRR29>3.0.CO;2-O
   Saeedi P, 2019, DIABETES RES CLIN PR, V157, DOI 10.1016/j.diabres.2019.107843
   Schanner C, 2016, SCAND J PUBLIC HEALT, V44, P765, DOI 10.1177/1403494816666732
   Seppälä J, 2012, J AFFECT DISORDERS, V136, P543, DOI 10.1016/j.jad.2011.10.032
   Shao H, 2019, PHARMACOECONOMICS, V37, P921, DOI 10.1007/s40273-019-00775-8
   Sheehan DV, 1998, J CLIN PSYCHIAT, V59, P22, DOI 10.4088/JCP.09m05305whi
   Sheehan DV LY, 1994, MINIINTERNATIONAL NE
   Steer RA, 1999, J CLIN PSYCHOL, V55, P117, DOI 10.1002/(SICI)1097-4679(199901)55:1<117::AID-JCLP12>3.0.CO;2-A
   Stojanovic M, 2018, CENT EUR J PUBL HEAL, V26, P104, DOI 10.21101/cejph.a5022
   Sun JC, 2015, DIABETIC MED, V32, P935, DOI 10.1111/dme.12649
   Takeuchi T, 2013, PSYCHIAT CLIN NEUROS, V67, P532, DOI 10.1111/pcn.12104
   Vanhala M, 2009, ACTA PSYCHIAT SCAND, V119, P137, DOI 10.1111/j.1600-0447.2008.01283.x
   Viinamäki H, 2004, NORD J PSYCHIAT, V58, P49, DOI 10.1080/08039480310000798
   von Bondorff MB, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0122134
   Wändell PE, 2005, SCAND J PRIM HEALTH, V23, P68, DOI 10.1080/02813430510015296
   Wang YP, 2013, REV BRAS PSIQUIATR, V35, P416, DOI 10.1590/1516-4446-2012-1048
   WARE JE, 1992, MED CARE, V30, P473, DOI 10.1097/00005650-199206000-00002
   Wasenius N, 2014, SCAND J MED SCI SPOR, V24, P404, DOI 10.1111/sms.12015
   Weisman A, 2018, CAN J CARDIOL, V34, P552, DOI 10.1016/j.cjca.2018.03.002
   World Health Organization, 2006, DEF DIAGN DIAB MELL
NR 42
TC 8
Z9 8
U1 0
U2 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
EI 2052-4897
J9 BMJ OPEN DIAB RES CA
JI BMJ Open Diab. Res. Care
PY 2020
VL 8
IS 1
AR e001568
DI 10.1136/bmjdrc-2020-001568
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA OL2XJ
UT WOS:000585205100004
PM 33077474
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chan, RNC
   Huang, CG
   Ng, NYH
   Tam, HCH
   Tam, CHT
   Cheng, FF
   Wong, KK
   Shi, M
   Ng, ACW
   Tsang, AYT
   Wang, CC
   Cheung, LP
   Tam, WH
   Joglekar, MV
   Hardikar, AA
   Jenkins, AJ
   Chan, JCN
   Lim, CKP
   Ma, RCW
AF Chan, Raymond N. C.
   Huang, Chuiguo
   Ng, Noel Y. H.
   Tam, Henry C. H.
   Tam, Claudia H. T.
   Cheng, Feifei
   Wong, Kwun Kiu
   Shi, Mai
   Ng, Alex C. W.
   Tsang, Atta Y. T.
   Wang, Chi Chiu
   Cheung, Lai Ping
   Tam, Wing Hung
   Joglekar, Mugdha V.
   Hardikar, Anandwardhan A.
   Jenkins, Alicia J.
   Chan, Juliana C. N.
   Lim, Cadmon K. P.
   Ma, Ronald C. W.
TI Shortened Relative Leukocyte Telomere Length Is Associated With
   Polycystic Ovary Syndrome and Metabolic Traits
SO ENDOCRINOLOGY DIABETES & METABOLISM
LA English
DT Article
DE dysglycemia; dyslipidemia; leukocyte telomere length; polycystic ovary
   syndrome
ID OXIDATIVE STRESS; CARDIOMETABOLIC RISK; INSULIN-RESISTANCE; CHINESE
   WOMEN; SYNDROME PCOS; PROGRESSION; PREVALENCE; DISEASE
AB Background: Polycystic ovary syndrome (PCOS) is one of the commonest gyneco-endocrine disorders amongst women of reproductive age. Whether PCOS and cardiometabolic traits in PCOS patients are associated with shortened telomere length (TL) or relative leukocyte telomere length (rLTL) remains unclear. Methods: 214 women with PCOS and 214 age-matched women were recruited. rLTL was measured with an updated quantitative real-time PCR protocol and reported as Delta Delta Ct between telomere and a single-copy gene encoding beta-globin relative to a normalisation control. A two-way Mendelian randomization analysis using the UK Biobank Resource was performed to assess the causal relationship between rLTL and PCOS. Results: Women with PCOS had significantly shortened rLTL (PCOS: 0.5 +/- 0.7; control: 0.8 +/- 0.6; p < 0.001). Longer rLTL was associated with a lower risk of PCOS after adjusting for age, history of smoking and other cardiometabolic traits (OR: 0.503; 95% CI: 0.342-0.730; p < 0.001). Longer rLTL was associated with reduced risk of dyslidpidemia (OR: 0.563; 95% CI: 0.450-0.968; p = 0.042) in PCOS patients. PCOS subjects with rLTL shorter than mean of the rLTL of control subjects had an elevated risk of dysglycemia (OR: 2.09; 95% CI: 1.04-4.29; p = 0.040). No causal relationships were found between rLTL and PCOS in the Mendelian randomization study. Conclusions: Women with PCOS have significantly reduced rLTL and shorter LTL may be associated with cardiometabolic risk factors in PCOS subjects. There are no causal relationship between genetically determined PCOS and TL or vice versa.
C1 [Chan, Raymond N. C.; Huang, Chuiguo; Ng, Noel Y. H.; Tam, Henry C. H.; Tam, Claudia H. T.; Cheng, Feifei; Wong, Kwun Kiu; Shi, Mai; Ng, Alex C. W.; Tsang, Atta Y. T.; Jenkins, Alicia J.; Chan, Juliana C. N.; Lim, Cadmon K. P.; Ma, Ronald C. W.] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Hong Kong, Peoples R China.
   [Wang, Chi Chiu; Cheung, Lai Ping; Tam, Wing Hung] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Obstet & Gynaecol, Hong Kong, Peoples R China.
   [Wang, Chi Chiu; Chan, Juliana C. N.; Lim, Cadmon K. P.; Ma, Ronald C. W.] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Hong Kong, Peoples R China.
   [Joglekar, Mugdha V.; Hardikar, Anandwardhan A.] Western Sydney Univ, Sch Med, Diabet & Islet Biol Grp, Sydney, NSW, Australia.
   [Jenkins, Alicia J.] Baker Heart & Diabet Inst, Melbourne, Vic, Australia.
   [Jenkins, Alicia J.] Univ Sydney, Fac Med & Hlth, NHMRC Clin Trial Ctr, Sydney, NSW, Australia.
   [Chan, Juliana C. N.; Ma, Ronald C. W.] Chinese Univ Hong Kong, Hong Kong Inst Diabet & Obes, Hong Kong, Peoples R China.
   [Chan, Juliana C. N.; Ma, Ronald C. W.] Chinese Univ Hong Kong, Shanghai Jiao Tong Univ Joint Res Ctr Diabet Genom, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong; Prince of Wales Hospital; Chinese
   University of Hong Kong; Prince of Wales Hospital; Chinese University of
   Hong Kong; Western Sydney University; Baker Heart and Diabetes
   Institute; University of Sydney; Chinese University of Hong Kong;
   Chinese University of Hong Kong
RP Ma, RCW (corresponding author), Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Hong Kong, Peoples R China.; Ma, RCW (corresponding author), Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Hong Kong, Peoples R China.; Ma, RCW (corresponding author), Chinese Univ Hong Kong, Hong Kong Inst Diabet & Obes, Hong Kong, Peoples R China.; Ma, RCW (corresponding author), Chinese Univ Hong Kong, Shanghai Jiao Tong Univ Joint Res Ctr Diabet Genom, Hong Kong, Peoples R China.
EM rcwma@cuhk.edu.hk
RI Wang, Ronald/C-6541-2014; Joglekar, Mugdha/AFP-0659-2022; chuiguo,
   huang/ADV-5549-2022; Tam, Hung/AAE-3628-2020; Chan, Raymond Ngai
   Chiu/GPC-8320-2022; Ma, Ronald/C-2788-2009
OI Ma, Ronald/0000-0002-1227-803X; Chan, Raymond Ngai
   Chiu/0000-0002-1678-9128
FU University Grants Committee Research Grants Matching Scheme; Chinese
   University of Hong Kong Direct Grant; Research Grants Council Research
   Impact Fund [R4012-18]; Croucher Foundation Senior Medical Research
   Fellowship; RGC General Research Fund [14110415, 14102719, CUHK473408,
   CUHK471713]
FX This project was supported by a Chinese University of Hong Kong Direct
   Grant and the University Grants Committee Research Grants Matching
   Scheme. RCWM acknowledge partial support from the Research Grants
   Council Research Impact Fund (R4012-18), and a Croucher Foundation
   Senior Medical Research Fellowship. The recruitment and follow-up of
   PCOS subjects and control subjects were previously supported by the RGC
   General Research Fund (ref. 14110415, 14102719, CUHK473408 and
   CUHK471713). The authors acknowledge Dr. Andrzej Januszewski and Dr.
   Luke Carroll (University of Sydney) for providing assistance for the DNA
   QC material.
CR Anagnostis P, 2021, ENDOCRINE, V74, P245, DOI 10.1007/s12020-021-02801-2
   [Anonymous], 2009, DIABETES CARE, V32, pS6, DOI 10.2337/dc09-S006
   Apridonidze T, 2005, J CLIN ENDOCR METAB, V90, P1929, DOI 10.1210/jc.2004-1045
   Azziz R, 2016, NAT REV DIS PRIMERS, V2, DOI 10.1038/nrdp.2016.57
   Belenkaia LV, 2019, MINERVA GINECOL, V71, P211, DOI 10.23736/S0026-4784.19.04404-6
   Burgess Stephen, 2019, Wellcome Open Res, V4, P186, DOI 10.12688/wellcomeopenres.15555.3
   Chang AY, 2016, CLIN ENDOCRINOL, V85, P92, DOI 10.1111/cen.12986
   Chazenbalk G, 2010, J CLIN ENDOCR METAB, V95, P935, DOI 10.1210/jc.2009-1158
   Cheng FF, 2022, DIABETES CARE, V45, P701, DOI 10.2337/dc21-1609
   Cheng FF, 2022, DIABETOLOGIA, V65, P375, DOI 10.1007/s00125-021-05613-1
   Cheng FF, 2021, ENDOCR CONNECT, V10, P1243, DOI 10.1530/EC-21-0082
   Cheng FF, 2021, LANCET DIABETES ENDO, V9, P117, DOI 10.1016/S2213-8587(20)30365-X
   Cheung LP, 2008, HUM REPROD, V23, P1431, DOI 10.1093/humrep/den090
   Pedroso DCC, 2015, FERTIL STERIL, V103, P542, DOI 10.1016/j.fertnstert.2014.10.035
   Codd V, 2021, NAT GENET, V53, P1425, DOI 10.1038/s41588-021-00944-6
   Day F, 2018, PLOS GENET, V14, DOI 10.1371/journal.pgen.1007813
   De Leo V, 2016, REPROD BIOL ENDOCRIN, V14, DOI 10.1186/s12958-016-0173-x
   Diamanti-Kandarakis E, 2012, ENDOCR REV, V33, P981, DOI 10.1210/er.2011-1034
   Ding ZH, 2014, NUCLEIC ACIDS RES, V42, DOI 10.1093/nar/gku181
   González F, 2006, J CLIN ENDOCR METAB, V91, P336, DOI 10.1210/jc.2005-1696
   Honig LS, 2012, ARCH NEUROL-CHICAGO, V69, P1332, DOI 10.1001/archneurol.2012.1541
   Joglekar MV, 2020, METHOD PROTOCOL, V3, DOI 10.3390/mps3020027
   Ladson G, 2011, FERTIL STERIL, V96, P224, DOI 10.1016/j.fertnstert.2011.05.002
   Li QL, 2014, J CLIN ENDOCR METAB, V99, pE234, DOI 10.1210/jc.2013-3685
   Lim SS, 2012, HUM REPROD UPDATE, V18, P618, DOI 10.1093/humupd/dms030
   Mannerås-Holm L, 2011, J CLIN ENDOCR METAB, V96, pE304, DOI 10.1210/jc.2010-1290
   McCartney CR, 2016, NEW ENGL J MED, V375, P54, DOI 10.1056/NEJMcp1514916
   Murri M, 2013, HUM REPROD UPDATE, V19, P268, DOI 10.1093/humupd/dms059
   Ng NYH, 2021, OBES RES CLIN PRACT, V15, P593, DOI 10.1016/j.orcp.2021.09.004
   Ng NYH, 2019, PLOS MED, V16, DOI 10.1371/journal.pmed.1002953
   Pedroso DCC, 2020, REPROD SCI, V27, P1293, DOI 10.1007/s43032-019-00120-6
   Petersen S, 1998, EXP CELL RES, V239, P152, DOI 10.1006/excr.1997.3893
   Rocha ALL, 2017, J ENDOCRINOL INVEST, V40, P1279, DOI 10.1007/s40618-017-0708-9
   Samavat H, 2021, INT J CANCER, V148, P352, DOI 10.1002/ijc.33211
   Sasamoto N, 2020, REPROD SCI, V27, P1951, DOI 10.1007/s43032-020-00214-6
   Sendur SN, 2021, REPROD BIOMED ONLINE, V42, P799, DOI 10.1016/j.rbmo.2020.12.006
   Tajada M, 2022, GYNECOL ENDOCRINOL, V38, P391, DOI 10.1080/09513590.2022.2047922
   Tam WH, 2017, DIABETES CARE, V40, P679, DOI 10.2337/dc16-2397
   Teede HJ, 2023, EUR J ENDOCRINOL, V189, pG43, DOI 10.1093/ejendo/lvad096
   Teede HJ, 2018, CLIN ENDOCRINOL, V89, P251, DOI 10.1111/cen.13795
   Vasilishina A, 2019, METHODS MOL BIOL, V1896, P39, DOI 10.1007/978-1-4939-8931-7_5
   Vasilopoulos E, 2019, INT J MOL MED, V44, P375, DOI 10.3892/ijmm.2019.4225
   Velazquez ME, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.604215
   Verhulst S, 2016, DIABETOLOGIA, V59, P1258, DOI 10.1007/s00125-016-3915-6
   Victor VM, 2011, J CLIN ENDOCR METAB, V96, P3115, DOI 10.1210/jc.2011-0651
   Yau TTL, 2017, HONG KONG MED J, V23, P622, DOI 10.12809/hkmj176308
   Zhao Y, 2013, STEROIDS, V78, P755, DOI 10.1016/j.steroids.2013.04.006
NR 47
TC 0
Z9 0
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2398-9238
J9 ENDOCRIN DIAB METAB
JI Endocrinol. Diabetes Metab.
PD MAR
PY 2025
VL 8
IS 2
AR e70030
DI 10.1002/edm2.70030
PG 12
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA X3F1Y
UT WOS:001424241400001
PM 39963020
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Emiliano, AF
   de Cavalho, LCRM
   Cordeiro, VDC
   da Costa, CA
   de Oliveira, PBR
   Queiroz, EF
   Moreira, DD
   Boaventura, GT
   de Moura, RS
   Resende, AC
AF Emiliano, Andrea Fernandes
   Reis Marins de Cavalho, Lenize Costa
   Cristino Cordeiro, Viviane da Silva
   da Costa, Cristiane Aguiar
   Raquel de Oliveira, Paola Braz
   Queiroz, Emerson Ferreira
   Moreira, Daniele Dal Col
   Boaventura, Gilson Teles
   de Moura, Roberto Soares
   Resende, Angela Castro
TI Metabolic Disorders and Oxidative Stress Programming in Offspring of
   Rats Fed a High-fat Diet During Lactation: Effects of a Vinifera
   Grape Skin (ACH09) Extract
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
LA English
DT Article
DE grape skin extract; hypertension; insulin resistance; oxidative stress;
   developmental programming
ID SPONTANEOUSLY HYPERTENSIVE-RATS; INSULIN-RESISTANCE; INDUCED OBESITY;
   BLOOD-PRESSURE; NITRIC-OXIDE; RICH DIET; ANTIOXIDANTS; MECHANISM;
   ANTHOCYANINS; VASODILATION
AB This study examined the effect of Vitis vinifera grape skin ACH09 extract (ACH09) on metabolic disorders and oxidative stress in adult offspring of rats fed a high-fat diet (HF) during lactation. Four groups of female rats were fed: control diet (7% fat); ACH09 (7% fat + 200 mg.kg(-1.)d(-1) ACH09 orally); HF (24% fat); HF+ ACH09 (24% fat + 200 mg.kg(-1.)d(-1) ACH09 orally) during lactation. From weaning onward, all female offspring were fed a control diet and killed when they were 90 or 180 days old. Systolic blood pressure was increased in adult offspring of HF-fed dams, and ACH09 prevented hypertension. Increased adiposity, plasma triglyceride, glucose levels, and insulin resistance were observed in offspring from both ages, and these changes were reversed by ACH09. The plasma oxidative damage assessed by malondialdehyde levels was increased, and nitrite levels decreased in the HF group of both ages, which were reversed by ACH09. In addition, ACH09 restored the decreased plasma and mesenteric artery antioxidant activities of superoxide dismutase, catalase, and glutathione peroxidase in the HF group. In conclusion, ACH09 protected normally fed offspring of HF-fed dams during lactation from phenotypic and metabolic characteristics of metabolic syndrome providing an alternative nutritional resource for the prevention of metabolic syndrome.
C1 [Emiliano, Andrea Fernandes; Reis Marins de Cavalho, Lenize Costa; Cristino Cordeiro, Viviane da Silva; da Costa, Cristiane Aguiar; Raquel de Oliveira, Paola Braz; de Moura, Roberto Soares; Resende, Angela Castro] Univ Estado Rio De Janeiro, Dept Pharmacol, Inst Biol, Rio De Janeiro, RJ, Brazil.
   [Queiroz, Emerson Ferreira; Moreira, Daniele Dal Col] Ache Labs SA, Dept Res Dev & Innovat, Guarulhos, Brazil.
   [Boaventura, Gilson Teles] Univ Fed Fluminense, Dept Expt Nutr, BR-24220000 Niteroi, RJ, Brazil.
C3 Universidade do Estado do Rio de Janeiro; Universidade Federal
   Fluminense
RP Resende, AC (corresponding author), Univ Estado Rio de Janeiro, Dept Farmacol & Psicobiol, Inst Biol, Av 28 Setembro,87, BR-20551030 Rio De Janeiro, Brazil.
EM angelacr@uerj.br
RI Resende, Angela/M-8632-2017; Costa, Cristiane/AAF-8475-2021; Queiroz,
   Emerson/AAU-6235-2020; Boaventura, Gilson/D-6317-2014
OI Aguiar da Costa, Cristiane/0000-0003-1927-1794; Boaventura, Gilson
   Teles/0000-0001-8376-330X; Ferreira Queiroz, Emerson/0000-0001-9567-1664
FU National Council of Scientific and Technological Development (CNPq); Rio
   de Janeiro State Research Agency (FAPERJ)
FX Supported by grants from the National Council of Scientific and
   Technological Development (CNPq) and Rio de Janeiro State Research
   Agency (FAPERJ).
CR Aebi H, 1984, Methods Enzymol, V105, P121
   Archuleta TL, 2009, FREE RADICAL BIO MED, V47, P1486, DOI 10.1016/j.freeradbiomed.2009.08.014
   Armitage JA, 2005, J PHYSIOL-LONDON, V565, P3, DOI 10.1113/jphysiol.2004.079756
   Ashton N, 2003, CLIN EXP PHARMACOL P, V30, P820, DOI 10.1046/j.1440-1681.2003.03918.x
   Balon TW, 1997, J APPL PHYSIOL, V82, P359, DOI 10.1152/jappl.1997.82.1.359
   BANNISTER JV, 1987, METHOD BIOCHEM ANAL, V32, P279
   BARKER DJP, 1995, EUR J CLIN INVEST, V25, P457, DOI 10.1111/j.1365-2362.1995.tb01730.x
   Bastard JP, 2006, EUR CYTOKINE NETW, V17, P4
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Bruce KD, 2009, HEPATOLOGY, V50, P1796, DOI 10.1002/hep.23205
   BRUINS AP, 1987, ANAL CHEM, V59, P2642, DOI 10.1021/ac00149a003
   Bub A, 2001, EUR J NUTR, V40, P113, DOI 10.1007/s003940170011
   Chang YC, 2010, AM J TRANSL RES, V2, P316
   CIERPIAL MA, 1987, AM J PHYSIOL, V253, pH980, DOI 10.1152/ajpheart.1987.253.4.H980
   de Moura RS, 2007, HYPERTENS PREGNANCY, V26, P89, DOI 10.1080/10641950601147960
   de Moura RS, 2004, J CARDIOVASC PHARM, V44, P302, DOI 10.1097/01.fjc.0000133060.10597.3c
   de Moura RS, 2002, J PHARM PHARMACOL, V54, P1515, DOI 10.1211/002235702153
   Devaskar SU, 2007, REV ENDOCR METAB DIS, V8, P105, DOI 10.1007/s11154-007-9050-4
   Dohadwala MM, 2009, J NUTR, V139, p1788S, DOI 10.3945/jn.109.107474
   Doyle K, 2010, J BIOL CHEM, V285, P17417, DOI 10.1074/jbc.M109.089250
   DRAPER HH, 1993, FREE RADICAL BIO MED, V15, P353, DOI 10.1016/0891-5849(93)90035-S
   Evans JL, 2007, INDIAN J MED RES, V125, P355
   Fitzpatrick DF, 2000, J AGR FOOD CHEM, V48, P6384, DOI 10.1021/jf0009347
   Flamini R, 2003, MASS SPECTROM REV, V22, P218, DOI 10.1002/mas.10052
   FLOHE L, 1984, METHOD ENZYMOL, V105, P114
   FRANKEL EN, 1993, LANCET, V341, P454, DOI 10.1016/0140-6736(93)90206-V
   Madeira SVF, 2009, J VASC RES, V46, P406, DOI 10.1159/000194271
   García-Beneytez E, 2003, J AGR FOOD CHEM, V51, P5622, DOI 10.1021/jf0302207
   Gorski JN, 2006, AM J PHYSIOL-REG I, V291, pR768, DOI 10.1152/ajpregu.00138.2006
   GREEN LC, 1982, ANAL BIOCHEM, V126, P131, DOI 10.1016/0003-2697(82)90118-X
   GUO F, 1995, PHYSIOL BEHAV, V57, P681, DOI 10.1016/0031-9384(94)00342-4
   Khan IY, 2005, AM J PHYSIOL-REG I, V288, pR127, DOI 10.1152/ajpregu.00354.2004
   Khan LY, 2003, HYPERTENSION, V41, P168, DOI 10.1161/01.HYP.0000047511.97879.FC
   Luo ZC, 2006, MED HYPOTHESES, V66, P38, DOI 10.1016/j.mehy.2005.08.020
   MABRY TJ, 1975, FLAVONOIDS 1
   Madeira SVF, 2005, PHARMACOL RES, V52, P321, DOI 10.1016/j.phrs.2005.05.005
   MARKHAM KR, 1975, FLAVONOIDS 1
   Matsuzawa-Nagata N, 2008, METABOLISM, V57, P1071, DOI 10.1016/j.metabol.2008.03.010
   MCGREGOR DD, 1965, J PHYSIOL-LONDON, V177, P21, DOI 10.1113/jphysiol.1965.sp007572
   MINAMI N, 1995, CLIN SCI, V89, P177, DOI 10.1042/cs0890177
   Nivoit P, 2009, DIABETOLOGIA, V52, P1133, DOI 10.1007/s00125-009-1316-9
   Ognibene DT, 2009, CLIN EXP PHARMACOL P, V36, P12, DOI 10.1111/j.1440-1681.2008.05054.x
   OTANI H, 2010, ANTIOXID REDOX SIGNA
   Plagemann A, 2005, PHYSIOL BEHAV, V86, P661, DOI 10.1016/j.physbeh.2005.08.065
   REEVES PG, 1993, J NUTR, V123, P1939, DOI 10.1093/jn/123.11.1939
   Rocha A. P. M., 2008, Journal of Pharmacology and Toxicology, V3, P435
   Roy D, 1998, AM J PHYSIOL-ENDOC M, V274, pE692, DOI 10.1152/ajpendo.1998.274.4.E692
   Samuelsson AM, 2008, HYPERTENSION, V51, P383, DOI 10.1161/HYPERTENSIONAHA.107.101477
   Seifried HE, 2007, J NUTR BIOCHEM, V18, P567, DOI 10.1016/j.jnutbio.2006.10.007
   Singleton VL, 1999, METHOD ENZYMOL, V299, P152
   Tao RY, 2009, EUR J PHARMACOL, V616, P328, DOI 10.1016/j.ejphar.2009.06.011
   Taylor PD, 2005, AM J PHYSIOL-REG I, V288, pR134, DOI 10.1152/ajpregu.00355.2004
   Touyz RM, 2011, HYPERTENS RES, V34, P5, DOI 10.1038/hr.2010.201
   Tsuda T, 2008, J AGR FOOD CHEM, V56, P642, DOI 10.1021/jf073113b
   Wang HB, 2003, J AGR FOOD CHEM, V51, P1839, DOI 10.1021/jf0260747
NR 55
TC 22
Z9 22
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0160-2446
EI 1533-4023
J9 J CARDIOVASC PHARM
JI J. Cardiovasc. Pharmacol.
PD SEP
PY 2011
VL 58
IS 3
BP 319
EP 328
DI 10.1097/FJC.0b013e3182244a51
PG 10
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 816KW
UT WOS:000294599400011
PM 21697730
DA 2025-06-11
ER

PT J
AU Bain, J
AF Bain, Jerald
TI Testosterone and the aging male: To treat or not to treat?
SO MATURITAS
LA English
DT Review
DE Aging male; Testosterone; Hypogonadism; Cardiovascular disease; Prostate
   cancer; Metabolic syndrome
ID ANDROGEN-DEPRIVATION THERAPY; CLINICAL-RESEARCH CENTER; LEAN BODY-MASS;
   PROSTATE-CANCER; OLDER MEN; REPLACEMENT THERAPY; METABOLIC SYNDROME;
   HYPOGONADAL MEN; INSULIN-RESISTANCE; ELDERLY-MEN
AB It is well-established that total testosterone (TT) in men decreases with age and that bioavailable testosterone (bio-T) falls to an even greater extent. The clinical relevance of declining androgens in the aging male and use of testosterone replacement therapy (TRT) in this situation is controversial. Most studies have been short term and there are no large randomized placebo-controlled trials. Testosterone has many physiological actions in: muscles, bones, hematopoietic system, brain, reproductive and sexual organs, adipose tissue. Within these areas it stimulates: muscle growth and maintenance, bone development while inhibiting bone resorption, the production of red blood cells to increase hemoglobin, libido, enhanced mood and cognition, erectile function and lipolysis. Anabolic deficits in aging men can induce: frailty, sarcopenia, poor muscle quality, muscle weakness, hypertrophy of adipose tissue and impaired neurotransmission. The aging male with reduced testosterone availability may present with a wide variety of symptoms which in addition to frailty and weakness include: fatigue, decreased energy, decreased motivation, cognitive impairment, decreased self-confidence, depression, irritability, osteoporotic pain and the lethargy of anemia. In addition, testosterone deficiency is also associated with type-2 diabetes, the metabolic syndrome, coronary artery disease, stroke and transient ischemic attacks, and cardiovascular disease in general. Furthermore, there are early studies to suggest that TRT in men with low testosterone levels may improve metabolic status by: lowering blood sugar and HbA1C in men with type-2 diabetes, reducing abdominal girth, ameliorating features of the metabolic syndrome, all of which may be protective of the cardiovascular system. The major safety issue is prostate cancer but there is no evidence that supports the idea that testosterone causes the development of a de novo cancer. So on balance in a man with symptoms of hygonadism and low or lowish levels of testosterone with no evidence of prostate cancer such as a normal PSA a therapeutic (4-6 months) trial of TRT is justified. Treatment and monitoring of this duration will determine whether the patient is responsive. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
C1 [Bain, Jerald] Mt Sinai Hosp, Div Endocrinol & Metab, Toronto, ON M5G 1X5, Canada.
   [Bain, Jerald] Univ Toronto, Dept Med, Toronto, ON M5S 1A1, Canada.
   [Bain, Jerald] Univ Toronto, Dept Obstet & Gynecol, Toronto, ON M5S 1A1, Canada.
C3 University of Toronto; Sinai Health System Toronto; Lunenfeld Tanenbaum
   Research Institute; University of Toronto; University of Toronto
RP Bain, J (corresponding author), Mt Sinai Hosp, Div Endocrinol & Metab, Suite 1501,600 Univ Ave, Toronto, ON M5G 1X5, Canada.
EM j.bain@utoronto.ca
FU former Organon Canada; Solvay Pharma; Schering-Plough and Paladin Labs
   Inc
FX The author has given lectures sponsored by the former Organon Canada and
   Solvay Pharma and has served on advisory boards of these companies. He
   has also given lectures sponsored by Schering-Plough and Paladin Labs
   Inc.
CR Azad N, 2003, J CLIN ENDOCR METAB, V88, P3064, DOI 10.1210/jc.2002-020632
   Bain J, 2007, CLIN INTERV AGING, V2, P567
   Bain J, 2007, J SEX MED, V4, P558, DOI 10.1111/j.1743-6109.2007.00488.x
   Barrett-Connor E, 1999, J CLIN ENDOCR METAB, V84, P573, DOI 10.1210/jc.84.2.573
   Basaria S, 2001, AM J MED, V110, P563, DOI 10.1016/S0002-9343(01)00663-5
   Basaria S, 2008, J ANDROL, V29, P534, DOI 10.2164/jandrol.108.005454
   Bhatia V, 2006, DIABETES CARE, V29, P2289, DOI 10.2337/dc06-0637
   Braga-Basaria M, 2006, J CLIN ONCOL, V24, P3979, DOI 10.1200/JCO.2006.05.9741
   Brodsky IG, 1996, J CLIN ENDOCR METAB, V81, P3469, DOI 10.1210/jc.81.10.3469
   Calof OM, 2005, J GERONTOL A-BIOL, V60, P1451, DOI 10.1093/gerona/60.11.1451
   Chodak GW, 2002, UROLOGY, V60, P201, DOI 10.1016/S0090-4295(02)01677-1
   CLAUSTRES M, 1988, HORM RES, V29, P17, DOI 10.1159/000180959
   Coviello AD, 2008, J CLIN ENDOCR METAB, V93, P914, DOI 10.1210/jc.2007-1692
   Davey RA, 2005, J BONE MINER METAB, V23, P212, DOI 10.1007/s00774-004-0586-z
   Dean John D, 2005, Rev Urol, V7, P87
   Dhindsa S, 2004, J CLIN ENDOCR METAB, V89, P5462, DOI 10.1210/jc.2004-0804
   English KM, 2000, CIRCULATION, V102, P1906, DOI 10.1161/01.CIR.102.16.1906
   Ferrini RL, 1998, AM J EPIDEMIOL, V147, P750
   Ferrucci L, 2006, ARCH INTERN MED, V166, P1380, DOI 10.1001/archinte.166.13.1380
   Fink HA, 2006, J CLIN ENDOCR METAB, V91, P3908, DOI 10.1210/jc.2006-0173
   Fonda SJ, 2005, J GERONTOL A-BIOL, V60, P385, DOI 10.1093/gerona/60.3.385
   FRIEDL KE, 1989, J CLIN ENDOCR METAB, V68, P971, DOI 10.1210/jcem-68-5-971
   FRIEDL KE, 1990, METABOLISM, V39, P69, DOI 10.1016/0026-0495(90)90150-B
   GODSLAND IF, 1987, AM HEART J, V114, P1467, DOI 10.1016/0002-8703(87)90552-7
   Greenlee M W, 2000, Int Rev Neurobiol, V44, P269
   Grossmann M, 2008, J CLIN ENDOCR METAB, V93, P1834, DOI 10.1210/jc.2007-2177
   Guay AT, 2009, J ANDROL, V30, P370, DOI 10.2164/jandrol.108.006015
   HAFFNER SM, 1994, METABOLISM, V43, P599, DOI 10.1016/0026-0495(94)90202-X
   Hammoud AO, 2006, J ANDROL, V27, P619, DOI 10.2164/jandrol.106.000125
   Hanafy HM, 2007, J SEX MED, V4, P1241, DOI 10.1111/j.1743-6109.2007.00553.x
   Handelsman DJ, 2007, J CLIN ENDOCR METAB, V92, P4505, DOI 10.1210/jc.2007-1431
   Harman SM, 2001, J CLIN ENDOCR METAB, V86, P724, DOI 10.1210/jc.86.2.724
   Heufelder AE, 2009, J ANDROL, V30, P726, DOI 10.2164/jandrol.108.007005
   Huggins C, 1941, CANCER RES, V1, P293
   Kaplan SA, 2006, J UROLOGY, V176, P1524, DOI 10.1016/j.juro.2006.06.003
   Kapoor D, 2006, EUR J ENDOCRINOL, V154, P899, DOI 10.1530/eje.1.02166
   Kapoor D, 2005, CLIN ENDOCRINOL, V63, P239, DOI 10.1111/j.1365-2265.2005.02299.x
   Katznelson L, 1996, J CLIN ENDOCR METAB, V81, P4358, DOI 10.1210/jc.81.12.4358
   Kaufman JM, 2005, ENDOCR REV, V26, P833, DOI 10.1210/er.2004-0013
   Keating NL, 2006, J CLIN ONCOL, V24, P4448, DOI 10.1200/JCO.2006.06.2497
   Kupelian V, 2008, J CLIN ENDOCR METAB, V93, P3403, DOI 10.1210/jc.2008-0054
   Liu PY, 2003, J CLIN ENDOCR METAB, V88, P3605, DOI 10.1210/jc.2003-030236
   Liu PY, 2003, ENDOCR REV, V24, P313, DOI 10.1210/er.2003-0005
   Lu-Yao G, 2004, J UROLOGY, V171, P2285, DOI 10.1097/01.ju.0000127740.96006.1a
   Marks LS, 2006, JAMA-J AM MED ASSOC, V296, P2351, DOI 10.1001/jama.296.19.2351
   Moffat SD, 2002, J CLIN ENDOCR METAB, V87, P5001, DOI 10.1210/jc.2002-020419
   Morgentaler A, 2006, UROLOGY, V68, P1263, DOI 10.1016/j.urology.2006.08.1058
   Morgentaler A, 2006, EUR UROL, V50, P935, DOI 10.1016/j.eururo.2006.06.034
   Page ST, 2005, J CLIN ENDOCR METAB, V90, P1502, DOI 10.1210/jc.2004-1933
   Pasquali R, 2006, FERTIL STERIL, V85, P1319, DOI 10.1016/j.fertnstert.2005.10.054
   PHILLIPS GB, 1994, ARTERIOSCLER THROMB, V14, P701, DOI 10.1161/01.ATV.14.5.701
   Pope HG, 2003, AM J PSYCHIAT, V160, P105, DOI 10.1176/appi.ajp.160.1.105
   Rhoden EL, 2004, NEW ENGL J MED, V350, P482, DOI 10.1056/NEJMra022251
   Saad F, 2008, J ANDROL, V29, P102, DOI 10.2164/jandrol.107.002774
   Saigal CS, 2007, CANCER-AM CANCER SOC, V110, P1493, DOI 10.1002/cncr.22933
   Schatzl G, 2001, PROSTATE, V47, P52
   Shahani S, 2008, J CLIN ENDOCR METAB, V93, P2042, DOI 10.1210/jc.2007-2595
   SHAHIDI NT, 1973, NEW ENGL J MED, V289, P72, DOI 10.1056/NEJM197307122890205
   SHOUPE D, 1984, FERTIL STERIL, V41, P385
   Sinha-Hikim I, 2006, J CLIN ENDOCR METAB, V91, P3024, DOI 10.1210/jc.2006-0357
   Slater S, 2000, DRUG AGING, V17, P431, DOI 10.2165/00002512-200017060-00001
   Smith MR, 2002, J CLIN ENDOCR METAB, V87, P599, DOI 10.1210/jc.87.2.599
   TAGGERT H, 1984, METABOLISM, V31, P1147
   Thompson IM, 2004, NEW ENGL J MED, V350, P2239, DOI 10.1056/NEJMoa031918
   Tivesten A, 2004, J BONE MINER RES, V19, P1833, DOI 10.1359/JBMR.040819
   Traish AM, 2009, J ANDROL, V30, P477, DOI 10.2164/jandrol.108.007245
   Traish AM, 2009, J ANDROL, V30, P363, DOI 10.2164/jandrol.108.006007
   Valenti G, 2008, AGING MALE, V11, P153, DOI 10.1080/13685530802571100
   VERMEULEN A, 1993, J CLIN ENDOCR METAB, V76, P1140, DOI 10.1210/jc.76.5.1140
   Wang C, 2004, J CLIN ENDOCR METAB, V89, P2085, DOI 10.1210/jc.2003-032006
   Wang C, 1996, J CLIN ENDOCR METAB, V81, P3578, DOI 10.1210/jc.81.10.3578
   Webb CM, 1999, CIRCULATION, V100, P1690, DOI 10.1161/01.CIR.100.16.1690
   WILSON JD, 1988, ENDOCR REV, V9, P181, DOI 10.1210/edrv-9-2-181
   Yeap BB, 2009, J CLIN ENDOCR METAB, V94, P2353, DOI 10.1210/jc.2008-2416
NR 74
TC 62
Z9 71
U1 0
U2 18
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD MAY
PY 2010
VL 66
IS 1
BP 16
EP 22
DI 10.1016/j.maturitas.2010.01.009
PG 7
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA 599ZN
UT WOS:000277953200004
PM 20153946
DA 2025-06-11
ER

PT J
AU Victoria-Montesinos, D
   Ballester, P
   Barcina-Pérez, P
   García-Muñoz, AM
AF Victoria-Montesinos, Desiree
   Ballester, Pura
   Barcina-Perez, Pablo
   Garcia-Munoz, Ana Maria
TI Systematic Review and Meta-Analysis of Sclerocarya birrea on
   Metabolic Disorders: Evidence from Preclinical Studies
SO METABOLITES
LA English
DT Article
DE Sclerocarya birrea; metabolic disorders;
   antihyperglycemic; cardiometabolic risk; nutraceuticals; polyphenols
ID BETA-CELL DYSFUNCTION; BARK AQUEOUS EXTRACT; INSULIN-RESISTANCE;
   GLUCOSE-TOLERANCE; NITRIC-OXIDE; ALPHA; PATHOGENESIS; AMYLASE; HOCHST;
   RISK
AB Background/Objectives: Metabolic disorders, including diabetes, obesity, and cardiovascular diseases, are significant global health issues. Nutraceuticals, such as Sclerocarya birrea (SB), known for its high polyphenol content, are increasingly explored for managing these conditions. This study aims to evaluate the antihyperglycemic, hypolipidemic, and antihypertensive effects of SB in animal models to understand its potential as a natural intervention for metabolic diseases. Methods: A systematic review and meta-analysis were conducted according to PRISMA guidelines. Searches across databases like PubMed, Web of Science, Embase, and Scopus identified studies using SB in animal models of metabolic disorders. Inclusion criteria were studies with SB intervention, control groups, and quantitative measures of metabolic parameters. The study was registered with INPLASY (INPLASY2024100031). Results: The meta-analysis revealed that SB significantly reduces blood glucose levels in diabetic animal models. Acute administration of SB showed a pooled standardized mean difference (SMD) of -7.13 (95% CI: -11.44 to -2.83) at 1 h and -9.75 (95% CI: -15.92 to -3.59) at 2-4 h post-administration. Chronic administration indicated a non-significant reduction in glucose levels (SMD: -5.69, 95% CI: -16.38 to 5.01). Conclusions: SB appears to have the potential for reducing blood glucose levels and may offer benefits for other cardiometabolic risk factors, including lipid profiles and oxidative stress. However, variability in the results underscores the need for further research, including standardized animal studies and clinical trials, to confirm these effects and clarify the mechanisms by which SB may impact metabolic disorders.
C1 [Victoria-Montesinos, Desiree; Ballester, Pura; Barcina-Perez, Pablo; Garcia-Munoz, Ana Maria] UCAM Univ Catolica Murcia, Fac Pharm & Nutr, Murcia 30107, Spain.
C3 Universidad Catolica de Murcia
RP Ballester, P (corresponding author), UCAM Univ Catolica Murcia, Fac Pharm & Nutr, Murcia 30107, Spain.
EM dvictoria@ucam.edu; pballester@ucam.edu; pbarcina@ucam.edu;
   amgarcia13@ucam.edu
RI Ballester, Pura/AAD-2635-2022; Victoria-Montesinos, Desirée/S-2566-2018;
   García Muñoz, Ana María/AAU-9143-2020
OI Garcia-Munoz/0000-0002-1021-5385; Ballester, Pura/0000-0002-7345-448X;
   Victoria-Montesinos, Desiree/0000-0003-3968-9477
CR Abdul-Ghani MA, 2006, DIABETES CARE, V29, P1130, DOI 10.2337/dc05-2179
   Allen RW, 2013, ANN FAM MED, V11, P452, DOI 10.1370/afm.1517
   [Anonymous], 2017, IDF Diabetes Atlas, V8th edn
   Armentano MF, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/561589
   Aronson JK, 2017, BRIT J CLIN PHARMACO, V83, P8, DOI 10.1111/bcp.12935
   automeris.io, WebPlotDigitizer-Copyright 2010-2024 Ankit Rohatgi
   Borochov-Neori H, 2008, J AGR FOOD CHEM, V56, P9884, DOI 10.1021/jf801467m
   Bougarne N, 2018, ENDOCR REV, V39, P760, DOI 10.1210/er.2018-00064
   Chakraborty R, 2021, J INTEGR MED-JIM, V19, P478, DOI 10.1016/j.joim.2021.09.006
   Dama A, 2024, NUTRIENTS, V16, DOI 10.3390/nu16040507
   Das L, 2012, J FOOD SCI TECH MYS, V49, P173, DOI 10.1007/s13197-011-0269-4
   Cádiz-Gurrea MD, 2019, MOLECULES, V24, DOI 10.3390/molecules24050966
   Dimo T, 2007, J ETHNOPHARMACOL, V110, P434, DOI 10.1016/j.jep.2006.10.020
   Dini I, 2022, MOLECULES, V27, DOI 10.3390/molecules27248777
   Djientcheu Tientcheu Jean Philippe, 2023, Evid Based Complement Alternat Med, V2023, P7865919, DOI 10.1155/2023/7865919
   Ellis LR, 2022, NUTR REV, V80, P1723, DOI 10.1093/nutrit/nuab104
   Enayati A, 2022, PPAR RES, V2022, DOI 10.1155/2022/4714914
   Entezari M, 2022, BIOMED PHARMACOTHER, V146, DOI 10.1016/j.biopha.2021.112563
   Fakudze NT, 2023, PHARMACEUTICALS-BASE, V16, DOI 10.3390/ph16081117
   Feingold KR., 2024, ENDOTEXT
   Fotio Agathe L., 2009, Inflammopharmacology, V17, P229, DOI 10.1007/s10787-009-0011-2
   Goel S, 2022, FRONT GENET, V13, DOI 10.3389/fgene.2022.1022739
   Gondwe M, 2008, PHYTOMEDICINE, V15, P699, DOI 10.1016/j.phymed.2008.02.004
   Hooijmans CR, 2014, BMC MED RES METHODOL, V14, DOI 10.1186/1471-2288-14-43
   Iqbal I, 2023, MOLECULES, V28, DOI 10.3390/molecules28176403
   Kato-Schwartz CG, 2018, J FUNCT FOODS, V44, P265, DOI 10.1016/j.jff.2018.03.025
   Kgopa A.H., 2020, Asian J. Chem, V32, P2195, DOI [10.14233/ajchem.2020.22693, DOI 10.14233/AJCHEM.2020.22693]
   Klec C, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20246110
   Krawczyk M, 2023, BIOMOLECULES, V13, DOI 10.3390/biom13091402
   Legeay S, 2015, NUTRIENTS, V7, P5443, DOI 10.3390/nu7075230
   Lekhuleni IL, 2024, DISCOV FOOD, V4, DOI 10.1007/s44187-024-00108-5
   Li FJ, 2013, BIOMED RES-TOKYO, V34, P167, DOI 10.2220/biomedres.34.167
   Li X, 2022, MOLECULES, V27, DOI 10.3390/molecules27020523
   Liu XL, 2019, EUR J CLIN NUTR, V73, P1, DOI 10.1038/s41430-018-0185-z
   Mabasa L, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19073782
   Magaia T. L. J., 2017, African Journal of Food, Agriculture, Nutrition and Development, V17, P12441, DOI 10.18697/ajfand.79.16140
   Manco M, 2010, DIABETES CARE, V33, P2090, DOI 10.2337/dc09-2261
   Quesille-Villalobos AM, 2013, CYTA-J FOOD, V11, P60, DOI 10.1080/19476337.2012.688219
   Martín MA, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10061474
   Mashau ME, 2022, INT J FOOD PROP, V25, P1549, DOI 10.1080/10942912.2022.2064491
   Matsubara K, 2015, INT J MOL SCI, V16, P4600, DOI 10.3390/ijms16034600
   Mawoza T, 2012, CARDIOVASC J AFR, V23, P12, DOI 10.5830/CVJA-2010-098
   Mogale MA, 2011, AFR J BIOTECHNOL, V10, P15033, DOI 10.5897/AJB11.1408
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Montgomery SE, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0107756
   Morvaridzadeh M, 2020, COMPLEMENT MED RES, V27, P348, DOI 10.1159/000506348
   Ndifossap IGM, 2010, J ENDOCRINOL, V205, P79, DOI 10.1677/JOE-09-0311
   Ngueguim FT, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1009-0
   Ojewole JAO, 2004, PHYTOTHER RES, V18, P601, DOI 10.1002/ptr.1503
   Ojewole JAO, 2003, PHYTOMEDICINE, V10, P675, DOI 10.1078/0944-7113-00295
   Ojewole John A O, 2006, Cardiovasc J S Afr, V17, P117
   Ormazabal V, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0762-4
   Palavesam A, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0049493, 10.1371/journal.pone.0044390]
   Pang J, 2016, INT J CARDIOL, V202, P967, DOI 10.1016/j.ijcard.2014.12.176
   Phillips CM, 2013, NUTRIENTS, V5, P32, DOI 10.3390/nu5010032
   Poli A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13082810
   Qiu LJ, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1216708
   Rudrapal M, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.806470
   Rufino MN, 2018, J NUTR BIOCHEM, V62, P1, DOI 10.1016/j.jnutbio.2018.05.016
   Russo D, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19010186
   Sahebkar A, 2016, PHARMACOL RES, V106, P37, DOI 10.1016/j.phrs.2016.02.008
   Sahebkar A, 2015, J FUNCT FOODS, V18, P898, DOI 10.1016/j.jff.2015.01.005
   Sewani-Rusike CR, 2021, PHARMACOGN MAG, V17, P482, DOI 10.4103/pm.pm_546_20
   Shekarchizadeh-Esfahani P, 2020, PHYTOTHER RES, V34, P475, DOI 10.1002/ptr.6543
   Sorrenti V, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24032019
   Sucato V, 2024, J CLIN MED, V13, DOI 10.3390/jcm13071882
   Tientcheu JPD, 2023, METAB BRAIN DIS, V38, P2773, DOI 10.1007/s11011-023-01291-7
   Victoria-Montesinos D, 2021, Ph.D. Thesis
   Victoria-Montesinos D, 2021, NUTRIENTS, V13, DOI 10.3390/nu13061948
   Wang B, 2021, SIGNAL TRANSDUCT TAR, V6, DOI 10.1038/s41392-020-00443-w
   who, Hypertension
   Xie WT, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.1015045
   Yahfoufi N, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111618
   Yang KY, 2018, ACTA PHARMACOL SIN, V39, P893, DOI 10.1038/aps.2017.174
   Fokko ZA, 2007, BBA-MOL CELL BIOL L, V1771, P972, DOI 10.1016/j.bbalip.2007.04.021
   Zeng LT, 2021, J IMMUNOL RES, V2021, DOI 10.1155/2021/7552546
   Zhao YZ, 2015, J PHARMACOL SCI, V129, P83, DOI 10.1016/j.jphs.2015.09.002
   Zhou M, 2023, J ENZYM INHIB MED CH, V38, DOI 10.1080/14756366.2023.2199168
NR 78
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD NOV
PY 2024
VL 14
IS 11
AR 615
DI 10.3390/metabo14110615
PG 24
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA N6O5I
UT WOS:001365509800001
PM 39590851
OA gold
DA 2025-06-11
ER

PT J
AU Petersson, H
   Risérus, U
   McMonagle, J
   Gulseth, HL
   Tierney, AC
   Morange, S
   Helal, O
   Shaw, DI
   Ruano, JA
   López-Miranda, J
   Kiec-Wilk, B
   Golabek, I
   Blaak, EE
   Saris, WHM
   Drevon, CA
   Lovegrove, JA
   Roche, HM
   Basu, S
AF Petersson, Helena
   Riserus, Ulf
   McMonagle, Jolene
   Gulseth, Hanne L.
   Tierney, Audrey C.
   Morange, Sophie
   Helal, Olfa
   Shaw, Danielle I.
   Ruano, Juan A.
   Lopez-Miranda, Jose
   Kiec-Wilk, Beata
   Golabek, Iwona
   Blaak, Ellen E.
   Saris, Wim H. M.
   Drevon, Christian A.
   Lovegrove, Julie A.
   Roche, Helen M.
   Basu, Samar
TI Effects of dietary fat modification on oxidative stress and inflammatory
   markers in the LIPGENE study
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Dietary fat; Oxidative stress; Inflammation; Metabolic syndrome; LIPGENE
   study
ID CATALYZED LIPID-PEROXIDATION; ACID; HUMANS; PROSTAGLANDIN-F2-ALPHA;
   RADIOIMMUNOASSAY; F-2-ISOPROSTANES; ASSOCIATION; BIOMARKERS; PRODUCTS;
   F2-ALPHA
AB Subjects with the metabolic syndrome (MetS) have enhanced oxidative stress and inflammation. Dietary fat quality has been proposed to be implicated in these conditions. We investigated the impact of four diets distinct in fat quantity and quality on 8-iso-PGF(2 alpha) (a major F(2)-isoprostane and oxidative stress indicator), 15-keto-13,14-dihydro-PGF(2 alpha) (15-keto-dihydro-PGF(2 alpha), a major PGF(2 alpha) metabolite and marker of cyclooxygenase-mediated inflammation) and C-reactive protein (CRP). In a 12-week parallel multicentre dietary intervention study (LIPGENE), 417 volunteers with the MetS were randomly assigned to one of the four diets: two high-fat diets (38% energy (% E)) rich in SFA or MUFA and two low-fat high-complex carbohydrate diets (28 % E) with (LFHCC n-3) or without (LFHCC) 1.24 g/d of very long chain n-3 fatty acid supplementation. Urinary levels of 8-iso-PGF(2 alpha) and 15-keto-dihydro-PGF(2 alpha) were determined by RIA and adjusted for urinary creatinine levels. Serum concentration of CRP was measured by ELISA. Neither concentrations of 8-iso-PGF(2 alpha) and 15-keto-dihydro-PGF(2 alpha) nor those of CRP differed between diet groups at baseline (P>0.07) or at the end of the study (P>0.44). Also, no differences in changes of the markers were observed between the diet groups (8-iso-PGF(2 alpha), P=0.83; 15-keto-dihydro-PGF(2 alpha), P=0.45; and CRP, P=0.97). In conclusion, a 12-week dietary fat modification did not affect the investigated markers of oxidative stress and inflammation among subjects with the MetS in the LIPGENE study.
C1 [Petersson, Helena; Riserus, Ulf; Basu, Samar] Uppsala Univ, Dept Publ Hlth & Caring Sci Clin Nutr & Metab, S-75185 Uppsala, Sweden.
   [McMonagle, Jolene; Tierney, Audrey C.; Roche, Helen M.] Univ Coll Dublin, Sch Publ Hlth & Populat Sci, UCD Conway Inst, Nutrigenom Res Grp, Dublin 4, Ireland.
   [Gulseth, Hanne L.] Univ Oslo, Oslo Univ Hosp Aker, Dept Endocrinol, Hormone Lab, Oslo, Norway.
   [Gulseth, Hanne L.; Drevon, Christian A.] Univ Oslo, Fac Med, Inst Basic Med Sci, Dept Nutr, Oslo, Norway.
   [Morange, Sophie] Aix Marseille Univ, Hop Concept, APH M, Ctr Invest Clin, Marseille, France.
   [Helal, Olfa] INSERM, Nutr Humaine & Lipides U476, F-13385 Marseille, France.
   [Helal, Olfa] INRA, Nutriments Lipid & Prevent Malad Metab UMR1260, F-13385 Marseille, France.
   [Helal, Olfa] Univ Aix Marseille 2, Fac Med, F-13385 Marseille, France.
   [Shaw, Danielle I.; Lovegrove, Julie A.] Univ Reading, Dept Food & Nutr Sci, Reading, Berks, England.
   [Ruano, Juan A.; Lopez-Miranda, Jose] Univ Cordoba, Lipids & Atherosclerosis Res Unit, Reina Sofia Univ Hosp,Inst Salud Carlos III, Maimonides Inst Biomed Res Cordoba IMIBIC, Cordoba, Spain.
   [Golabek, Iwona] Jagiellonian Univ, Coll Med, Dept Clin Biochem, Krakow, Poland.
   [Blaak, Ellen E.; Saris, Wim H. M.] Maastricht Univ, Sch Metab Toxicol & Nutr, NUTRIM, Dept Human Biol, Maastricht, Netherlands.
   [Lovegrove, Julie A.] Univ Reading, ICMR, Reading, Berks, England.
C3 Uppsala University; University College Dublin; University of Oslo;
   University of Oslo; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Aix-Marseille Universite; Assistance
   Publique-Hopitaux de Marseille; Institut National de la Sante et de la
   Recherche Medicale (Inserm); INRAE; Aix-Marseille Universite; University
   of Reading; Hospital Universitario Reina Sofia - Cordoba; Instituto de
   Salud Carlos III; Universidad de Cordoba; Jagiellonian University;
   Collegium Medicum Jagiellonian University; Maastricht University;
   University of Reading
RP Risérus, U (corresponding author), Uppsala Univ, Dept Publ Hlth & Caring Sci Clin Nutr & Metab, Uppsala Sci Pk, S-75185 Uppsala, Sweden.
EM ulf.riserus@pubcare.uu.se
RI Drevon, Christian/F-6012-2010; Ruano, Juan/T-1991-2018; Tierney,
   Audrey/AAB-7068-2022; Lovegrove, Julie/LRV-2592-2024; Lopez-Miranda,
   Jose/Y-8306-2019; Shaw, Danielle/HGA-4994-2022; Blaak, Ellen/E-3459-2015
OI Tierney, Audrey/0000-0001-8562-2877; Blaak, Ellen/0000-0002-2496-3464;
   Lopez-Miranda, Jose/0000-0002-8844-0718; Roche,
   Helen/0000-0002-0628-3318; Ruano, Juan/0000-0002-0286-4107
FU LIPGENE - an European Union [FOOD-CT-2003-505944]; NordForsk (Nordic
   Centre of Excellence in Food, Nutrition and Health (SYSDIET)); Swedish
   Nutrition Foundation; Norwegian Foundation for Health and Rehabilitation
FX We would like to thank all the persons involved in the LIPGENE project
   at all the clinical centres. J. M., H. L. G., A. C. T., S. M., O. H., D.
   I. S., J. A. R., J. L.-M., B. K.-W., I. G., E. E. B., W. H. M. S., C. A.
   D., J. A. L. and H. M. R. designed and organised the original LIPGENE
   study and data collection. U. R. and H. P. conceived the present
   substudy and drafted the manuscript. H. P. performed the statistical
   analyses, and S. B. analysed the oxidative stress markers. All the
   authors contributed to critical revision of the manuscript. The work was
   supported by LIPGENE - an European Union 6th Framework Program
   Integrated Project (FOOD-CT-2003-505944), NordForsk (Nordic Centre of
   Excellence in Food, Nutrition and Health (SYSDIET)), Swedish Nutrition
   Foundation and the Norwegian Foundation for Health and Rehabilitation.
   None of the authors has any conflicts of interest.
CR Basu S, 1998, PROSTAG LEUKOTR ESS, V58, P319, DOI 10.1016/S0952-3278(98)90042-4
   Basu S, 1998, PROSTAG LEUKOTR ESS, V58, P347, DOI 10.1016/S0952-3278(98)90070-9
   Basu S, 2008, ANTIOXID REDOX SIGN, V10, P1405, DOI 10.1089/ars.2007.1956
   Basu S, 2007, MED RES REV, V27, P435, DOI 10.1002/med.20098
   Galli C, 2009, ANN NUTR METAB, V55, P123, DOI 10.1159/000228999
   Grundy SM, 2004, ARTERIOSCL THROM VAS, V24, pE13, DOI 10.1161/01.ATV.0000111245.75752.C6
   Helmersson J, 2004, CIRCULATION, V109, P1729, DOI 10.1161/01.CIR.0000124718.99562.91
   Hodson L, 2008, PROG LIPID RES, V47, P348, DOI 10.1016/j.plipres.2008.03.003
   Jialal I, 2002, FREE RADICAL RES, V36, P1331, DOI 10.1080/1071576021000038531
   Kadiiska MB, 2005, FREE RADICAL BIO MED, V38, P698, DOI 10.1016/j.freeradbiomed.2004.09.017
   Kadiiska MB, 2005, FREE RADICAL BIO MED, V38, P711, DOI 10.1016/j.freeradbiomed.2004.10.024
   Mori TA, 2003, FREE RADICAL BIO MED, V35, P772, DOI 10.1016/S0891-5849(03)00407-6
   Nälsén C, 2006, J NUTR, V136, P1222
   Pickup JC, 2004, DIABETES CARE, V27, P813, DOI 10.2337/diacare.27.3.813
   Shaw DI, 2009, BRIT J NUTR, V101, P750, DOI 10.1017/S0007114508039962
   Södergren E, 2001, EUR J CLIN NUTR, V55, P922, DOI 10.1038/sj.ejcn.1601246
   Turpeinen AM, 1998, PROSTAG LEUKOTR ESS, V59, P229, DOI 10.1016/S0952-3278(98)90067-9
   WAGNER BA, 1994, BIOCHEMISTRY-US, V33, P4449, DOI 10.1021/bi00181a003
NR 18
TC 29
Z9 32
U1 0
U2 6
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
J9 BRIT J NUTR
JI Br. J. Nutr.
PD NOV
PY 2010
VL 104
IS 9
BP 1357
EP 1362
DI 10.1017/S000711451000228X
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 677TS
UT WOS:000284015300012
PM 20569506
OA Bronze
DA 2025-06-11
ER

PT J
AU Wan, ST
   Wu, WB
   Zhang, Y
   He, J
   Wang, XP
   An, P
   Luo, JJ
   Zhu, YH
   Luo, YT
AF Wan, Sitong
   Wu, Wenbin
   Zhang, Yan
   He, Jian
   Wang, Xiaoping
   An, Peng
   Luo, Junjie
   Zhu, Yinhua
   Luo, Yongting
TI Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A
   Systematic Review and Meta-Analysis
SO NUTRIENTS
LA English
DT Review
DE antioxidant functional lipids; cardiovascular disease; meta-analysis
ID BETA-CAROTENE; MODERATELY OVERWEIGHT; SCIENTIFIC STATEMENT; OXIDATIVE
   STRESS; NITRIC-OXIDE; DOUBLE-BLIND; VITAMIN-E; DISEASE; ASTAXANTHIN;
   HYPERTENSION
AB The efficacy of functional lipids with antioxidant properties in reducing cardiovascular risk has not been consistent. Randomized controlled trials (RCTs) reporting estimates for the effects of antioxidant functional lipid supplementations on cardiometabolic risk factors were searched up to 1 May 2024. Overall, antioxidant lipid supplementations, compared with placebo, had favorable effects on systolic blood pressure (lycopene: -1.95 [-3.54, -0.36] mmHg), low-density lipoprotein cholesterol (n6 fatty acid: -0.39 [-0.71, -0.06] mmol/L; astaxanthin: -0.11 [-0.21, -0.01] mmol/L), high-density lipoprotein cholesterol (n3 fatty acid: 0.20 [0.13, 0.27] mmol/L; n6 fatty acid: 0.08 [0.01, 0.14] mmol/L; astaxanthin: 0.13 [0.05, 0.21] mmol/L), total cholesterol (n6 fatty acid: -0.24 [-0.37, -0.11] mmol/L; astaxanthin: -0.22 [-0.32, -0.12] mmol/L; beta-carotene: -0.13 [-0.23, -0.04] mmol/L), triglyceride (n3 fatty acid: -0.37 [-0.47, -0.28] mmol/L; astaxanthin: -0.46 [-0.83, -0.10] mmol/L), and fasting blood insulin (astaxanthin: -2.66 [-3.98, -1.34] pmol/L). The benefits of antioxidant lipid supplementations appeared to be most evident in blood pressure and blood lipids in participants with different cardiometabolic health statuses. Notably, n9 fatty acid increased triglyceride and hemoglobin A1C in the total population, which increases CVD risk. Antioxidant lipid supplementations ameliorate cardiometabolic risk factors, while their effect may depend on type and cardiometabolic health status. Long-term RCTs are needed to corroborate risk-benefit ratios across different antioxidant functional lipid supplementation settings.
C1 [Wan, Sitong; Zhang, Yan; Luo, Yongting] Gansu Agr Univ, Coll Food Sci & Engn, Lanzhou 730070, Peoples R China.
   [Wan, Sitong; Wu, Wenbin; An, Peng; Luo, Yongting] China Agr Univ, Dept Nutr & Hlth, Key Lab Precis Nutr & Food Qual, Beijing 100193, Peoples R China.
   [He, Jian] Natl Ctr Technol Innovat Dairy, Hohhot 010110, Peoples R China.
   [Wang, Xiaoping] Zhejiang Med Co Ltd, Shaoxing 312366, Peoples R China.
   [Luo, Junjie] Food Lab Zhongyuan, Luohe 462300, Peoples R China.
   [Zhu, Yinhua] China Acad Chinese Med Sci, Artemisinin Res Ctr, State Key Lab Qual Ensurance & Sustainable Use Dao, Beijing 100700, Peoples R China.
   [Zhu, Yinhua] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China.
C3 Gansu Agricultural University; China Agricultural University; China
   Academy of Chinese Medical Sciences; China Academy of Chinese Medical
   Sciences; Institute of Chinese Materia Medica, CACMS
RP Luo, YT (corresponding author), Gansu Agr Univ, Coll Food Sci & Engn, Lanzhou 730070, Peoples R China.; Luo, YT (corresponding author), China Agr Univ, Dept Nutr & Hlth, Key Lab Precis Nutr & Food Qual, Beijing 100193, Peoples R China.; Luo, JJ (corresponding author), Food Lab Zhongyuan, Luohe 462300, Peoples R China.; Zhu, YH (corresponding author), China Acad Chinese Med Sci, Artemisinin Res Ctr, State Key Lab Qual Ensurance & Sustainable Use Dao, Beijing 100700, Peoples R China.; Zhu, YH (corresponding author), China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China.
EM adeline7wan@163.com; wwb091828@163.com; zhangyan@gsau.edu.cn;
   hejian@yili.com; wangxiaoping@zmc.top; an-peng@cau.edu.cn;
   luojj@cau.edu.cn; zhuyinhua@cau.edu.cn; luo.yongting@cau.edu.cn
RI xiaoping, wang/GRX-3807-2022; Zhu, Yinhua/JHU-9736-2023; An,
   Peng/GWZ-9176-2022; Luo, Junjie/HPD-1151-2023
OI Luo, Yongting/0000-0001-7834-8742; Luo, Junjie/0000-0002-8987-0533; Wu,
   Wenbin/0009-0007-2290-4333; An, Peng/0000-0002-0421-0035
FU National Key R&D Program of China [2023YFF1103501]
FX This work was supported by the National Key R&D Program of China
   (2023YFF1103501).
CR Afshin A, 2019, LANCET, V393, P1958, DOI 10.1016/S0140-6736(19)30041-8
   Alabdulkarim Badriah, 2012, Journal of King Saud University Science, V24, P319, DOI 10.1016/j.jksus.2012.03.001
   An P, 2022, J AM COLL CARDIOL, V80, P2269, DOI 10.1016/j.jacc.2022.09.048
   [Anonymous], 1999, Stata Tech. Bull
   Appel LJ, 2006, HYPERTENSION, V47, P296, DOI 10.1161/01.HYP.0000202568.01167.B6
   Asemi Z, 2016, CLIN NUTR, V35, P819, DOI 10.1016/j.clnu.2015.07.009
   Aune D, 2018, AM J CLIN NUTR, V108, P1069, DOI 10.1093/ajcn/nqy097
   Bhuvaneswari S, 2012, CAN J PHYSIOL PHARM, V90, P1544, DOI 10.1139/y2012-119
   Bowman L, 2018, NEW ENGL J MED, V379, P1540, DOI 10.1056/NEJMoa1804989
   Chen JX, 2022, PHENOMICS, V2, P419, DOI 10.1007/s43657-022-00067-w
   Chen QH, 2021, WORLD J CLIN CASES, V9, P6591, DOI 10.12998/wjcc.v9.i23.6591
   Chiavaroli L, 2021, BMJ-BRIT MED J, V374, DOI 10.1136/bmj.n1651
   Coombes JS, 2016, AM J CLIN NUTR, V103, P283, DOI 10.3945/ajcn.115.115477
   Cumpston M, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.ED000142
   Deng XJ, 2024, EXPLORATION-PRC, V4, DOI 10.1002/EXP.20230090
   Egger M, 1997, BMJ-BRIT MED J, V315, P629, DOI 10.1136/bmj.315.7109.629
   Förstermann U, 2012, EUR HEART J, V33, P829, DOI 10.1093/eurheartj/ehr304
   Froyen E, 2020, NUTRIENTS, V12, DOI 10.3390/nu12082329
   Gajendragadkar PR, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0099070
   García-Lluch G, 2024, JPAD-J PREV ALZHEIM, DOI 10.14283/jpad.2024.16
   Gnoni A, 2016, J PHYSIOL BIOCHEM, V72, P485, DOI 10.1007/s13105-016-0495-3
   Gormaz JG, 2022, J AM COLL CARDIOL, V80, P2286, DOI 10.1016/j.jacc.2022.10.011
   Guyatt GH, 2008, BRIT MED J, V336, P924, DOI 10.1136/bmj.39489.470347.AD
   Higgins JPT, 2003, BMJ-BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557
   Hu QQ, 2022, INNOVATION-AMSTERDAM, V3, DOI 10.1016/j.xinn.2022.100214
   Huang QR, 2024, PHENOMICS, V4, P91, DOI 10.1007/s43657-023-00115-z
   Ide K, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0706-8
   Ishiki M, 2013, ENDOCRINOLOGY, V154, P2600, DOI 10.1210/en.2012-2198
   Jackson D, 2012, STAT MED, V31, P3805, DOI 10.1002/sim.5453
   Langsted A, 2008, CIRCULATION, V118, P2047, DOI 10.1161/CIRCULATIONAHA.108.804146
   Lee SPS, 2012, BRIT J NUTR, V108, P1280, DOI 10.1017/S0007114511006519
   Lenters-Westra E, 2014, NETH J MED, V72, P462
   Limonte CP, 2021, DIABETOLOGIA, V64, P437, DOI 10.1007/s00125-020-05300-7
   McEneny J, 2013, J NUTR BIOCHEM, V24, P163, DOI 10.1016/j.jnutbio.2012.03.015
   Miller ER, 2013, DIABETES CARE, V36, P1462, DOI 10.2337/dc12-1940
   Palozza P, 1998, NUTR REV, V56, P257, DOI 10.1111/j.1753-4887.1998.tb01762.x
   Powell-Wiley TM, 2021, CIRCULATION, V143, pE984, DOI 10.1161/CIR.0000000000000973
   RIBAYAMERCADO JD, 1995, J AM COLL NUTR, V14, P614
   Riley RD, 2010, BMJ-BRIT MED J, V340, DOI 10.1136/bmj.c221
   Rosei CA, 2023, HIGH BLOOD PRESS CAR, V30, P255, DOI 10.1007/s40292-023-00578-1
   Saeidi A, 2023, NUTRIENTS, V15, DOI 10.3390/nu15020286
   Samimi M, 2015, CLIN NUTR, V34, P388, DOI 10.1016/j.clnu.2014.06.005
   Shamseer L, 2015, BMJ-BRIT MED J, V349, DOI 10.1136/bmj.g7647
   Stefan N, 2023, LANCET DIABETES ENDO, V11, P426, DOI 10.1016/S2213-8587(23)00086-4
   Tang MM, 2019, FOOD FUNCT, V10, P4649, DOI [10.1039/c9fo00076c, 10.1039/C9FO00076C]
   Thies F, 2012, AM J CLIN NUTR, V95, P1013, DOI 10.3945/ajcn.111.026286
   Tribble DL, 1999, CIRCULATION, V99, P591, DOI 10.1161/01.CIR.99.4.591
   Truscott TG, 1996, J PHOTOCH PHOTOBIO B, V35, P233, DOI 10.1016/S1011-1344(96)07299-5
   UMANS JG, 1995, ANNU REV PHYSIOL, V57, P771, DOI 10.1146/annurev.ph.57.030195.004011
   Urakaze M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124381
   Vo V, 2024, J IMMIGR MINOR HEALT, V26, P409, DOI 10.1007/s10903-023-01489-y
   Wei M, 2000, CIRCULATION, V101, P2047, DOI 10.1161/01.CIR.101.17.2047
   Wolak T, 2019, NUTRIENTS, V11, DOI 10.3390/nu11050950
   Yang Y, 2011, J NUTR, V141, P1611, DOI 10.3945/jn.111.142109
   Yu QQ, 2018, BIOMED PHARMACOTHER, V103, P1327, DOI 10.1016/j.biopha.2018.04.143
   Zhang B., 2024, The Innovation Medicine, V2, P100063, DOI [10.59717/j.xinn-med.2024.100063, DOI 10.59717/J.XINN-MED.2024.100063]
   Zhang HY, 2019, J CELL BIOCHEM, V120, P19541, DOI 10.1002/jcb.29262
NR 57
TC 1
Z9 1
U1 4
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2024
VL 16
IS 14
AR 2213
DI 10.3390/nu16142213
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ZU0K1
UT WOS:001277682100001
PM 39064656
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Park, S
   Kim, M
   Paik, JK
   Jang, YJ
   Lee, SH
   Lee, JH
AF Park, Seonmin
   Kim, Minjoo
   Paik, Jean Kyung
   Jang, Yoon-Jung
   Lee, Sang-Hyun
   Lee, Jong Ho
TI Oxidative stress is associated with C-reactive protein in nondiabetic
   postmenopausal women, independent of obesity and insulin resistance
SO CLINICAL ENDOCRINOLOGY
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; LIPID-PEROXIDATION;
   METABOLIC SYNDROME; HEALTHY-MEN; CARDIOVASCULAR-DISEASE; IN-VIVO;
   INFLAMMATION; MARKERS; RISK
AB Objective Oxidative stress is associated with obesity, metabolic syndrome and inflammation, suggesting it could be an early event in the pathology of chronic diseases. We tested the hypothesis that elevated levels of oxidative stress markers are associated with increased C-reactive protein (CRP) and that this is independent of obesity and insulin resistance. Research design and methods This study was cross-sectional designed and nondiabetic postmenopausal women (n=1821) with CRP levels 10mg/l was enrolled. The CRP levels were categorized into quartiles from the lowest to the highest concentrations (Q1-Q4). The degree of insulin resistance was determined using the homoeostasis model assessment of insulin resistance (HOMA-IR). We measured oxidative stress using urinary 8-epi-prostaglandin F2 (8-epi-PGF2) and plasma oxidized low-density lipoprotein (ox-LDL). Results After adjustments for age and lifestyle habits, including smoking and drinking, we found higher body mass index (BMI) and HOMA-IR scores in Q2 and Q3 vs Q1. The Q4 BMI and HOMA-IR scores were higher than all other quartiles. The plasma ox-LDL was higher in Q4 than in Q1. Urinary 8-epi-PGF2 was higher in Q3 and Q4 than in Q1 or Q2. Urinary 8-epi-PGF2 positively correlated with CRP (r=0 center dot 235, P<0 center dot 001), whereas no correlation was found between ox-LDL and CRP. Multiple linear regression analyses of BMI and HOMA-IR showed that the association between urinary 8-epi-PGF2 and CRP levels remained significant (P<0 center dot 001). Conclusions Oxidative stress measured by increased concentration of urine 8-epi-PGF2 is strongly associated with CRP levels. This finding was independent of obesity and insulin resistance in nondiabetic postmenopausal women.
C1 [Park, Seonmin; Jang, Yoon-Jung; Lee, Jong Ho] Yonsei Univ, Interdisciplinary Course Sci Aging, Seoul 120749, South Korea.
   [Kim, Minjoo; Lee, Jong Ho] Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, Natl Leading Res Lab Clin Nutrigenet Nutrigen, Seoul 120749, South Korea.
   [Kim, Minjoo; Lee, Jong Ho] Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, Brain Korea Project 21, Seoul 120749, South Korea.
   [Paik, Jean Kyung] Eulji Univ, Dept Food & Nutr, Gyeonggi Do, South Korea.
   [Lee, Sang-Hyun] Natl Hlth Insurance Corp Ilsan Hosp, Dept Family Practice, Goyang Si, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University; Eulji
   University
RP Lee, JH (corresponding author), Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, 134 Shinchon Dong, Seoul 120749, South Korea.
EM jhleeb@yonsei.ac.kr
RI Kim, Minjoo/AEN-5516-2022
FU National Research Foundation, Ministry of Education, Science and
   Technology, Republic of Korea [2012-0005604]; Kyungil University,
   Republic of Korea
FX This study was supported by National Research Foundation, Ministry of
   Education, Science and Technology (Mid-career Researcher Program:
   2012-0005604), Republic of Korea and the Kyungil University Grant,
   Republic of Korea.
CR Barinas-Mitchell E, 2001, AM J EPIDEMIOL, V153, P1094, DOI 10.1093/aje/153.11.1094
   Basu S, 2004, FREE RADICAL RES, V38, P105, DOI 10.1080/10715760310001646895
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Chou HH, 2010, METABOLISM, V59, P824, DOI 10.1016/j.metabol.2009.09.030
   Chun S, 1999, CLIN CHEM LAB MED, V37, P969, DOI 10.1515/CCLM.1999.143
   Couillard C, 2005, J CLIN ENDOCR METAB, V90, P6454, DOI 10.1210/jc.2004-2438
   Ehara S, 2001, CIRCULATION, V103, P1955, DOI 10.1161/01.cir.103.15.1955
   Federico A, 2007, INT J CANCER, V121, P2381, DOI 10.1002/ijc.23192
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gopaul NK, 2000, FREE RADICAL RES, V33, P115, DOI 10.1080/10715760000300671
   Greendale GA, 1999, LANCET, V353, P571, DOI 10.1016/S0140-6736(98)05352-5
   Hopps E, 2010, NUTR METAB CARDIOVAS, V20, P72, DOI 10.1016/j.numecd.2009.06.002
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Hulthe J, 2001, CLIN SCI, V100, P371, DOI [10.1042/CS20000269, 10.1042/cs1000371]
   IL'Yasova D, 2008, BIOMARKERS, V13, P41, DOI 10.1080/13547500701617708
   Kanabrocki EL, 2002, CHRONOBIOL INT, V19, P423, DOI 10.1081/CBI-120002914
   Kim JY, 2008, AM J CLIN NUTR, V88, P630, DOI 10.1093/ajcn/88.3.630
   Kuhn H, 1997, J CLIN INVEST, V99, P888, DOI 10.1172/JCI119253
   Kundu JK, 2012, FREE RADICAL BIO MED, V52, P2013, DOI 10.1016/j.freeradbiomed.2012.02.035
   Meigs JB, 2007, DIABETES CARE, V30, P2529, DOI 10.2337/dc07-0817
   Morrow JD, 2002, AM J RESP CRIT CARE, V166, pS25, DOI 10.1164/rccm.2206011
   Morteza A, 2011, EUR CYTOKINE NETW, V22, P107, DOI 10.1684/ecn.2011.0282
   Niehoff AG, 2007, DIABETES CARE, V30, P1627, DOI 10.2337/dc06-2531
   Proudfoot JM, 2009, J LIPID RES, V50, P716, DOI 10.1194/jlr.M800607-JLR200
   Richelle M, 1999, FEBS LETT, V459, P259, DOI 10.1016/S0014-5793(99)01259-4
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Roberts LJ, 2002, CELL MOL LIFE SCI, V59, P808, DOI 10.1007/s00018-002-8469-8
   Roberts LJ, 2000, FREE RADICAL BIO MED, V28, P505, DOI 10.1016/S0891-5849(99)00264-6
   Roest M, 2008, J CLIN LIPIDOL, V2, P298, DOI 10.1016/j.jacl.2008.06.004
   Sánchez-Rodríguez MA, 2012, MENOPAUSE, V19, P361, DOI 10.1097/gme.0b013e318229977d
   Schwedhelm E, 2004, CIRCULATION, V109, P843, DOI 10.1161/01.CIR.0000116761.93647.30
   Sjogren P, 2005, ARTERIOSCL THROM VAS, V25, P2580, DOI 10.1161/01.ATV.0000190675.08857.3d
   Xu Y, 2011, ENDOCRINE, V39, P175, DOI 10.1007/s12020-010-9425-2
   Yudkin JS, 2000, ATHEROSCLEROSIS, V148, P209, DOI 10.1016/S0021-9150(99)00463-3
   Zhang YC, 2012, CELL BIOCHEM BIOPHYS, V62, P365, DOI 10.1007/s12013-011-9295-0
NR 35
TC 16
Z9 16
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD JUL
PY 2013
VL 79
IS 1
BP 65
EP 70
DI 10.1111/j.1365-2265.2012.04512.x
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 158SP
UT WOS:000319993500010
PM 22816656
DA 2025-06-11
ER

PT J
AU Morvaridzadeh, M
   Qorbani, M
   Eshkiki, ZS
   Estêvao, MD
   Ganjaroudi, NM
   Toupchian, O
   Abdollahi, S
   Pizarro, AB
   Abu-Zaid, A
   Zadro, JR
   Heshmati, J
   Ziaei, S
AF Morvaridzadeh, Mojgan
   Qorbani, Mostafa
   Eshkiki, Zahra Shokati
   Estevao, M. Dulce
   Ganjaroudi, Negar Mohammadi
   Toupchian, Omid
   Abdollahi, Shima
   Beatriz Pizarro, Ana
   Abu-Zaid, Ahmed
   Zadro, Joshua R.
   Heshmati, Javad
   Ziaei, Somayeh
TI The effect of almond intake on cardiometabolic risk factors,
   inflammatory markers, and liver enzymes: A systematic review and
   meta-analysis
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE almond; blood lipids; cardiometabolic; glycemic control; hepatic
   enzymes; inflammation
ID TYPE-2 DIABETES-MELLITUS; LIPID PROFILE; BLOOD-PRESSURE; DOSE-RESPONSE;
   CARDIOVASCULAR-DISEASE; NUT PHYTOCHEMICALS; OXIDATIVE STRESS;
   BODY-COMPOSITION; TREE NUTS; VITAMIN-E
AB Almond intake may be correlated with improvements in several cardiometabolic parameters, but its effects are controversial in the published literature, and it needs to be comprehensively summarized. We conducted a systematic search in several international electronic databases, including MEDLINE, EMBASE, Scopus, Web of Science, Cochrane Central Register of Controlled Trials, and until April 2021 to identify randomized controlled trials that examined the effects of almond consumption on cardiometabolic risk factors, inflammatory markers, and liver enzymes. Data were pooled using the random-effects model method and presented as standardized mean differences (SMDs) with 95% confidence intervals (CIs). Twenty-six eligible trials were analyzed (n = 1750 participants). Almond intake significantly decreased diastolic blood pressure, total cholesterol, triglyceride, low-density lipoprotein (LDL), non-high-density lipoprotein (HDL), and very LDL (p < 0.05). The effects of almond intake on systolic blood pressure, fasting blood glucose, insulin, hemoglobin A1c, homeostatic model assessment of insulin resistance, C-peptide, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, C-reactive protein (CRP), hs-CRP (high sensitivity C-reactive protein), interleukin 6, tumor necrosis factor-alpha, ICAM (Intercellular Adhesion Molecule), VCAM (Vascular Cell Adhesion Molecule), homocysteine, HDL, ox-LDL, ApoA1, ApoB, and lipoprotien-a were not statistically significant (p > .05). The current body of evidence supports the ingestion of almonds for their beneficial lipid-lowering and antihypertensive effects. However, the effects of almonds on antiinflammatory markers, glycemic control, and hepatic enzymes should be further evaluated via performing more extensive randomized trials.
C1 [Morvaridzadeh, Mojgan; Heshmati, Javad] Kermanshah Univ Med Sci, Songhor Healthcare Ctr, Kermanshah, Iran.
   [Qorbani, Mostafa] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.
   [Qorbani, Mostafa] Univ Tehran Med Sci, Chron Dis Res Ctr, Endocrinol & Metab Populat Sci Inst, Tehran, Iran.
   [Eshkiki, Zahra Shokati] Ahvaz Jundishapur Univ Med Sci, Alimentary Tract Res Ctr, Clin Sci Reseaech Inst, Ahvaz, Iran.
   [Estevao, M. Dulce] Univ Algarve, Escola Super Saude, Faro, Portugal.
   [Ganjaroudi, Negar Mohammadi] Shahid Beheshti Univ Med Sci, Sch Med, Tehran, Iran.
   [Toupchian, Omid; Abdollahi, Shima] North Khorasan Univ Med Sci, Sch Hlth, Dept Nutr & Publ Hlth, Bojnurd, Iran.
   [Beatriz Pizarro, Ana] Fdnn Valle Lili, Clin Res Ctr, Cali, Colombia.
   [Abu-Zaid, Ahmed] Univ Tennessee, Coll Grad Hlth Sci, Dept Pharmacol, Hlth Sci Ctr, Memphis, TN USA.
   [Zadro, Joshua R.] Univ Sydney, Fac Med & Hlth, Sydney Sch Publ Hlth, Camperdown, NSW, Australia.
   [Ziaei, Somayeh] Kermanshah Univ Med Sci, Emam Reza Hosp, ICU Dept, Kermanshah, Iran.
C3 Kermanshah University of Medical Sciences; Alborz University of Medical
   Sciences; Tehran University of Medical Sciences; Ahvaz Jundishapur
   University of Medical Sciences (AJUMS); Universidade do Algarve; Shahid
   Beheshti University Medical Sciences; North Khorasan University of
   Medical Sciences; University of Tennessee System; University of
   Tennessee Health Science Center; University of Sydney; Kermanshah
   University of Medical Sciences
RP Heshmati, J (corresponding author), Kermanshah Univ Med Sci, Songhor Healthcare Ctr, Kermanshah, Iran.; Qorbani, M (corresponding author), Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.; Ziaei, S (corresponding author), Kermanshah Univ Med Sci, Emam Reza Hosp, ICU Dept, Kermanshah, Iran.
EM mqorbani1379@yahoo.com; javad.heshmati@gmail.com;
   somaye.ziaie@kums.ac.ir
RI Eshkiki, Zahra/ABD-6918-2020; Qorbani, Mostafa/M-8171-2017; Ahmed,
   Ahmed/JHS-7565-2023; heshmati, javad/H-6812-2019; Morvaridzadeh,
   Mojgan/GLU-6418-2022; Zadro, Joshua/AAD-5961-2019; Toupchian,
   Omid/ACR-6829-2022; Pizarro, Ana/AAC-8021-2022; Abdollahi,
   Shima/AAA-8999-2020; Estevao, Dulce/I-4695-2014
OI Pizarro, Ana Beatriz/0000-0003-4089-454X; Abu-Zaid,
   Ahmed/0000-0003-2286-2181; Abdollahi, Shima/0000-0002-2638-7448;
   Estevao, Dulce/0000-0002-7151-8363
CR Abazarfard Z, 2016, IRAN RED CRESCENT ME, V18, DOI 10.5812/ircmj.23628
   Abazarfard Z, 2014, J RES MED SCI, V19, P457
   Alasalvar C, 2015, BRIT J NUTR, V113, pS68, DOI 10.1017/S0007114514003729
   Barreca D, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030672
   Bento APN, 2014, NUTR METAB CARDIOVAS, V24, P1330, DOI 10.1016/j.numecd.2014.07.002
   Berryman CE, 2015, J AM HEART ASSOC, V4, DOI 10.1161/JAHA.114.000993
   Blomhoff R, 2006, BRIT J NUTR, V96, pS52, DOI 10.1017/BJN20061864
   Bolling BW, 2011, NUTR RES REV, V24, P244, DOI 10.1017/S095442241100014X
   Bowen J, 2019, CLIN NUTR ESPEN, V30, P10, DOI 10.1016/j.clnesp.2018.12.088
   Chen CYO, 2015, NUTR J, V14, DOI 10.1186/s12937-015-0049-5
   Chen CM, 2017, NUTR METAB, V14, DOI 10.1186/s12986-017-0205-3
   Chen CY, 2007, J NUTR BIOCHEM, V18, P785, DOI 10.1016/j.jnutbio.2006.12.015
   Coates AM, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041180
   Cohen AE, 2011, METABOLISM, V60, P1312, DOI 10.1016/j.metabol.2011.01.017
   Cohen J., 1988, STAT POWER ANAL BEHA, DOI [10.4324/9780203771587, DOI 10.4324/9780203771587]
   Del Gobbo LC, 2015, AM J CLIN NUTR, V102, P1347, DOI 10.3945/ajcn.115.110965
   Dhillon J, 2018, NUTRIENTS, V10, DOI 10.3390/nu10080960
   Di Angelantonio E, 2015, JAMA-J AM MED ASSOC, V314, P52, DOI 10.1001/jama.2015.7008
   Dikariyanto V, 2020, AM J CLIN NUTR, V111, P1178, DOI 10.1093/ajcn/nqaa100
   Eckel R. H., 2014, Circulation, V129, pS76, DOI [10.1016/j.jacc.2013.11.003, 10.1161/01.cir.0000437740.48606.d1]
   Egger M, 1997, BMJ-BRIT MED J, V315, P629, DOI 10.1136/bmj.315.7109.629
   Eslampour E, 2020, COMPLEMENT THER MED, V50, DOI 10.1016/j.ctim.2020.102399
   Fox CS, 2015, DIABETES CARE, V38, P1777, DOI [10.1161/CIR.0000000000000230, 10.2337/dci15-0012]
   Galli F, 2017, FREE RADICAL BIO MED, V102, P16, DOI 10.1016/j.freeradbiomed.2016.09.017
   Gambardella J, 2020, BIOMEDICINES, V8, DOI 10.3390/biomedicines8080277
   Go AS, 2013, CIRCULATION, V127, P143, DOI [10.1161/CIR.0b013e318282ab8f, 10.1161/CIR.0000000000000366]
   Griel AE, 2006, BRIT J NUTR, V96, pS68, DOI 10.1017/BJN20061866
   Grundy SM, 2019, J AM COLL CARDIOL, V73, P3168, DOI [10.1016/j.jacc.2018.11.002, 10.1161/CIR.0000000000000625, 10.1016/j.jacc.2018.11.003]
   GULLESTAD L, 1992, ALCOHOL CLIN EXP RES, V16, P986, DOI 10.1111/j.1530-0277.1992.tb01906.x
   Hanna A, 2020, CARDIOVASC DRUG THER, V34, P849, DOI 10.1007/s10557-020-07071-0
   Higgins JPT, 2002, STAT MED, V21, P1539, DOI 10.1002/sim.1186
   Imig JD, 2019, PHYSIOL RES, V68, P695, DOI 10.33549/physiolres.934291
   Izzo AA, 2016, PHYTOTHER RES, V30, P691, DOI 10.1002/ptr.5591
   Jaceldo-Siegl K, 2004, BRIT J NUTR, V92, P533, DOI 10.1079/BJN20041223
   Jamshed H, 2015, J NUTR, V145, P2287, DOI 10.3945/jn.114.207944
   Jenkins DJA, 2008, J NUTR, V138, P908, DOI 10.1093/jn/138.5.908
   Jenkins DJA, 2008, METABOLISM, V57, P882, DOI 10.1016/j.metabol.2008.01.032
   Jenkins DJA, 2002, CIRCULATION, V106, P1327, DOI 10.1161/01.CIR.0000028421.91733.20
   Jung H, 2018, EUR J NUTR, V57, P2069, DOI 10.1007/s00394-017-1480-5
   Lee-Bravatti MA, 2019, ADV NUTR, V10, P1076, DOI 10.1093/advances/nmz043
   Lelong H, 2015, AM J HYPERTENS, V28, P362, DOI 10.1093/ajh/hpu164
   Li Z, 2020, J KING SAUD UNIV SCI, V32, P1757, DOI 10.1016/j.jksus.2020.01.013
   Liu JF, 2013, EUR J NUTR, V52, P927, DOI 10.1007/s00394-012-0400-y
   Liu K, 2020, AM J CLIN NUTR, V111, P219, DOI 10.1093/ajcn/nqz280
   Liu Y, 2018, J MED FOOD, V21, P340, DOI 10.1089/jmf.2017.3976
   Liu Y, 2017, NUTR RES PRACT, V11, P479, DOI 10.4162/nrp.2017.11.6.479
   de Souza RGM, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081750
   de Souza RGM, 2018, NUTRITION, V55-56, P154, DOI 10.1016/j.nut.2018.06.001
   Mazidi M, 2020, HIGH BLOOD PRESS CAR, V27, P133, DOI 10.1007/s40292-020-00364-3
   Miranda JJ, 2019, NAT MED, V25, P1667, DOI 10.1038/s41591-019-0644-7
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Munteanu A, 2007, MOL ASPECTS MED, V28, P538, DOI 10.1016/j.mam.2007.07.001
   Musa-Veloso K, 2016, J NUTR SCI, V5, DOI 10.1017/jns.2016.19
   Palacios OM, 2020, J AM COLL NUTR, V39, P397, DOI 10.1080/07315724.2019.1660929
   Pervez MA, 2018, TURK J GASTROENTEROL, V29, P170, DOI 10.5152/tjg.2018.17297
   Rajaram S, 2010, BRIT J NUTR, V103, P907, DOI 10.1017/S0007114509992480
   Ros E, 2015, BRIT J NUTR, V113, pS111, DOI 10.1017/S0007114514003924
   Savica V, 2010, ANNU REV NUTR, V30, P365, DOI 10.1146/annurev-nutr-010510-103954
   Schincaglia RM, 2020, COMPLEMENT THER MED, V52, DOI 10.1016/j.ctim.2020.102479
   Shi YJ, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21072612
   Tan SY, 2013, EUR J CLIN NUTR, V67, P1205, DOI 10.1038/ejcn.2013.184
   Tindall AM, 2019, AM J CLIN NUTR, V109, P297, DOI 10.1093/ajcn/nqy236
   Tyrrell DJ, 2021, NAT REV CARDIOL, V18, P58, DOI 10.1038/s41569-020-0431-7
   Viguiliouk E, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0103376
   Williamson EM, 2020, BRIT J PHARMACOL, V177, P1227, DOI 10.1111/bph.14943
   Zhao JV, 2019, BMC MED, V17, DOI 10.1186/s12916-019-1293-x
   Zibaeenezhad MJ, 2019, COMPLEMENT THER MED, V42, P33, DOI 10.1016/j.ctim.2018.10.013
NR 67
TC 8
Z9 8
U1 2
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD DEC
PY 2022
VL 36
IS 12
BP 4325
EP 4344
DI 10.1002/ptr.7622
EA NOV 2022
PG 20
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 6W1BK
UT WOS:000878605700001
PM 36331011
OA Green Published
DA 2025-06-11
ER

PT J
AU Drake, C
   Lian, T
   Trogdon, JG
   Edelman, D
   Eisenson, H
   Weinberger, M
   Reiter, K
   Shea, CM
AF Drake, Connor
   Lian, Tyler
   Trogdon, Justin G.
   Edelman, David
   Eisenson, Howard
   Weinberger, Morris
   Reiter, Kristin
   Shea, Christopher M.
TI Evaluating the association of social needs assessment data with
   cardiometabolic health status in a federally qualified community health
   center patient population
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Article
DE Social determinants of health; Social needs; Primary care; Predictive
   analytics; Electronic health record
ID DETERMINANTS; RISK; MEDICARE; TOOLS
AB Background Health systems are increasingly using standardized social needs screening and response protocols including the Protocol for Responding to and Assessing Patients' Risks, Assets, and Experiences (PRAPARE) to improve population health and equity; despite established relationships between the social determinants of health and health outcomes, little is known about the associations between standardized social needs assessment information and patients' clinical condition. Methods In this cross-sectional study, we examined the relationship between social needs screening assessment data and measures of cardiometabolic clinical health from electronic health records data using two modelling approaches: a backward stepwise logistic regression and a least absolute selection and shrinkage operation (LASSO) logistic regression. Primary outcomes were dichotomized cardiometabolic measures related to obesity, hypertension, and atherosclerotic cardiovascular disease (ASCVD) 10-year risk. Nested models were built to evaluate the utility of social needs assessment data from PRAPARE for risk prediction, stratification, and population health management. Results Social needs related to lack of housing, unemployment, stress, access to medicine or health care, and inability to afford phone service were consistently associated with cardiometabolic risk across models. Model fit, as measured by the c-statistic, was poor for predicting obesity (logistic = 0.586; LASSO = 0.587), moderate for stage 1 hypertension (logistic = 0.703; LASSO = 0.688), and high for borderline ASCVD risk (logistic = 0.954; LASSO = 0.950). Conclusions Associations between social needs assessment data and clinical outcomes vary by cardiometabolic condition. Social needs assessment data may be useful for prospectively identifying patients at heightened cardiometabolic risk; however, there are limits to the utility of social needs data for improving predictive performance.
C1 [Drake, Connor; Lian, Tyler] Duke Univ, Dept Populat Hlth Sci, Sch Med, 215 Morris St, Durham, NC 27701 USA.
   [Drake, Connor; Trogdon, Justin G.; Weinberger, Morris; Reiter, Kristin; Shea, Christopher M.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Hlth Policy & Management, 135 Dauer Dr, Chapel Hill, NC 27519 USA.
   [Edelman, David] Duke Univ, Sch Med, Dept Med, 2301 Erwin Rd, Durham, NC 27705 USA.
   [Edelman, David] Durham VA Healthcare Syst, 508 Fulton St, Durham, NC 27705 USA.
   [Eisenson, Howard] Lincoln Community Hlth Ctr, 1301 Fayetteville St, Durham, NC 27707 USA.
   [Eisenson, Howard] Duke Univ, Sch Med, Dept Family Med & Community Hlth, DUMC 2914, Durham, NC 27710 USA.
C3 Duke University; University of North Carolina; University of North
   Carolina Chapel Hill; Duke University; Duke University
RP Drake, C (corresponding author), Duke Univ, Dept Populat Hlth Sci, Sch Med, 215 Morris St, Durham, NC 27701 USA.
EM connor.drake@duke.edu
OI Edelman, David/0000-0001-7112-6151; Drake, Connor/0000-0002-5393-6246
FU BlueCross BlueShield of North Carolina Foundation; National Heart, Lung,
   And Blood Institute of the National Institutes of Health [K12HL138030];
   National Heart Lung and Blood Institute [K12HL138030] Funding Source:
   NIH RePORTER
FX This study was supported in part by the BlueCross BlueShield of North
   Carolina Foundation and by the National Heart, Lung, And Blood Institute
   of the National Institutes of Health under Award Number K12HL138030.
CR Ahrens A, 2019, ARXIV190105397
   Alley DE, 2016, NEW ENGL J MED, V374, P8, DOI 10.1056/NEJMp1512532
   Anderson AC, 2018, HEALTH AFFAIR, V37, P371, DOI 10.1377/hlthaff.2017.1301
   [Anonymous], 2011, Community-Centered Health Homes
   Bachrach D., 2014, Addressing patients social needs: an emerging business case for provider investment
   Beck AF, 2018, PEDIATR RES, V84, P10, DOI [10.1038/S41390-018-0012-1, 10.1038/s41390-018-0012-1]
   Bennett G., 2008, Obesity epidemiology, P342, DOI [10.1093/acprof:oso/9780195312911.003.0017, DOI 10.1093/ACPROF:OSO/9780195312911.003.0017]
   Billioux A, 2017, NAM PERSPECTIVES
   Booske BridgetC., 2010, Different Perspectives for Assigning Weights to Determinants of Health
   Byhoff E, 2019, AM J PREV MED, V57, pS74, DOI 10.1016/j.amepre.2019.07.017
   Chen M, 2020, J AM MED INFORM ASSN, V27, P1764, DOI 10.1093/jamia/ocaa143
   Cohen Mandy K, 2019, N C Med J, V80, P277, DOI 10.18043/ncm.80.5.277
   DELONG ER, 1988, BIOMETRICS, V44, P837, DOI 10.2307/2531595
   Doyle SK, 2019, CURR HYPERTENS REP, V21, DOI 10.1007/s11906-019-0962-7
   Drake C., 2019, Assessing and addressing social needs in primary care, DOI [10.1056/CAT.19.0693, DOI 10.1056/CAT.19.0693]
   Fraze TK, 2019, JAMA NETW OPEN, V2, DOI 10.1001/jamanetworkopen.2019.11514
   Frizzell JD, 2017, JAMA CARDIOL, V2, P204, DOI 10.1001/jamacardio.2016.3956
   Garg A, 2015, PEDIATRICS, V135, pE296, DOI 10.1542/peds.2014-2888
   Gold R, 2018, ANN FAM MED, V16, P399, DOI 10.1370/afm.2275
   Gottlieb L, 2016, HEALTH AFFAIR, V35, P2116, DOI 10.1377/hlthaff.2016.0723
   Gottlieb LM, 2017, AM J PREV MED, V53, P719, DOI 10.1016/j.amepre.2017.05.011
   HEDIS N., 2009, Healthcare effectiveness data and information set
   Heinze G, 2018, BIOMETRICAL J, V60, P431, DOI 10.1002/bimj.201700067
   Henrikson NB, 2019, AM J PREV MED, V57, pS13, DOI 10.1016/j.amepre.2019.07.012
   Hosmer D. W., 2000, APPL LOGISTIC REGRES, DOI [DOI 10.1002/0471722146, https://doi.org/10.1002/0471722146]
   Joynt KE, 2017, NEW ENGL J MED, V376, P510, DOI 10.1056/NEJMp1616278
   Karmali KN, 2014, J AM COLL CARDIOL, V64, P959, DOI 10.1016/j.jacc.2014.06.1186
   Kennedy P., 2003, A Guide to Econometrics
   Kreatsoulas C, 2010, CAN J CARDIOL, V26, p8C, DOI 10.1016/S0828-282X(10)71075-8
   Lloyd-Jones DM, 2017, J AM COLL CARDIOL, V69, P365, DOI [10.1016/j.jacc.2016.08.085, 10.1161/CIR.0000000000000467, 10.1016/j.jacc.2016.10.018]
   Marmot M, 2001, B WORLD HEALTH ORGAN, V79, P988
   Miller PE, 2019, J CARD FAIL, V25, P479, DOI 10.1016/j.cardfail.2019.01.018
   Moore J, 2018, MEDICAID ACCESS COVE
   National Academies of Sciences E and Medicine, 2016, ACCOUNTING SOCIAL RI
   National Association of Community Health Centers, 2016, PRAPARE IMPL ACT TOO
   Neuwirth Esther Estee B, 2007, Perm J, V11, P12
   People H., 2020, Healthy people 2020 objectives
   PRAPARE Validation Using 8, 2020, PRAPARE VAL US 8 GOL PRAPARE VAL US 8 GOL
   StataCorp, 2019, Stata Statistical Software: Release 16
   Steyerberg EW, 2001, J CLIN EPIDEMIOL, V54, P774, DOI 10.1016/S0895-4356(01)00341-9
   Theiss J, 2017, J LAW MED ETHICS, V45, P431, DOI 10.1177/1073110517737543
   Thomas-Henkel C., 2017, Screening for Social Determinants of Health in Populations with Complex Needs: Implementation Considerations
   van der Ploeg Tjeerd, 2016, BMC Res Notes, V9, P147, DOI 10.1186/s13104-016-1945-2
   Virani SS, 2020, CIRCULATION, V141, pE139, DOI 10.1161/CIR.0000000000000757
   Weir CR, 2018, ASSESSING RELATIONSH
   Weir RC, 2020, J HEALTH CARE POOR U, V31, P1018, DOI 10.1353/hpu.2020.0075
   Wells Brian J, 2013, EGEMS (Wash DC), V1, P1035, DOI 10.13063/2327-9214.1035
   Whelton PK, 2018, J AM COLL CARDIOL, V71, P2199, DOI 10.1016/j.jacc.2017.11.005
NR 48
TC 11
Z9 11
U1 0
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD JUL 14
PY 2021
VL 21
IS 1
AR 342
DI 10.1186/s12872-021-02149-5
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA TM2KW
UT WOS:000675381400002
PM 34261446
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Burgueño, AL
   Juárez, YR
   Genaro, AM
   Tellechea, ML
AF Burgueno, Adriana L.
   Juarez, Yamila R.
   Genaro, Ana M.
   Tellechea, Mariana L.
TI Prenatal stress and later metabolic consequences: Systematic review and
   meta-analysis in rodents
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE Low birth weight; Maternal stress; Corticosteroids; Metabolic syndrome;
   Systolic blood pressure
ID FAT-SUCROSE DIET; LOW-BIRTH-WEIGHT; PSYCHOSOCIAL STRESS;
   SEXUAL-BEHAVIOR; BLOOD-PRESSURE; ADULT HEALTH; DISEASE RISK; OUTCOMES;
   CHILDHOOD; EXPOSURE
AB Background: Numerous rodent studies have evaluated the effects of maternal stress (MS) on later in life susceptibility to Metabolic Syndrome (MetS) intermediate phenotypes with varying results. The aim of this study was to quantitatively synthesize the available data on the effects of MS on offspring obesity, estimated indirectly by body mass (BM), body fat (BF) and plasma leptin; systolic blood pressure (SBP); plasma glucose (and insulin) and blood lipid concentrations.
   Methods: Literature was screened and summary estimates of the effect of MS outcomes were calculated by using random-effects models. Data on the effects of exogenous corticosteroid administration (or inhibition of 11 beta-HSD2) during pregnancy in rodents was analysed separately to characterize the direct phenotypic effects of prenatal corticosteroid excess (PCE).
   Results: We conducted 14 separate meta-analyses and synthesized relevant data on outcomes scarcely reported in literature. Both MS and PCE were associated with low birth weight without rapid catch-up growth resulting in decreased body mass later in life. Our analysis also revealed significant and contradictory effects on offspring adiposity. Little evidence was found for effects on glucose metabolism and blood lipids. We identified increased SBP in offspring exposed to PCE; however, there is not enough data to draw any conclusion about effects of MS on SBP.
   Conclusions: Neonatal weight proved to be decreased in offspring prenatally exposed to stress or corticosteroids, but laboratory rodents in the absence of a challenging environment did not show catch-up growth. The available evidence is inconclusive regarding the effect on adiposity revealing clear methodological and knowledge gaps. This meta-analysis also confirmed a significant positive association between PCE and SBP. Nevertheless, additional studies should address the association with MS.
C1 [Burgueno, Adriana L.; Juarez, Yamila R.; Genaro, Ana M.] Pontificia Univ Catolica Argentina, Inst Invest Biomed, CONICET, Alicia Moreau de Justo 1600,C1107AFF, Buenos Aires, DF, Argentina.
   [Tellechea, Mariana L.] Hosp Ninos Dr Ricardo Gutierrez, Div Endocrinol, Fdn Endocrinol Infanta, Ctr Invest Endocrinol Dr Cesar Bergad,Consejo Nac, Gallo 1330,C1425EFD, Buenos Aires, DF, Argentina.
C3 Pontificia Universidad Catolica Argentina; Consejo Nacional de
   Investigaciones Cientificas y Tecnicas (CONICET); Hospital de Ninos
   Doctor Ricardo Gutierrez; University of Buenos Aires; University of
   Buenos Aires Hospital
RP Tellechea, ML (corresponding author), Hosp Ninos Dr Ricardo Gutierrez, Div Endocrinol, Fdn Endocrinol Infanta, Ctr Invest Endocrinol Dr Cesar Bergad,Consejo Nac, Gallo 1330,C1425EFD, Buenos Aires, DF, Argentina.
EM alburgueno@conicet.gov.ar; yamila_juarez@uca.edu.ar;
   ana_genaro@uca.edu.ar; mtellechea@cedie.org.ar
RI TELLECHEA, MARIANA/AAM-6673-2021
OI TELLECHEA, MARIANA LORENA/0000-0002-1194-8433; Burgueno, Adriana
   L./0000-0001-7584-7044; Genaro, Ana/0000-0003-0027-3503
FU ANPCyT [PICT-2015-1567, PICT-2016-2727]; CONICET [PIP-2015-No0163]
FX This study was partially supported by ANPCyT (grants PICT-2015-1567,
   PICT-2016-2727) and CONICET (grant PIP-2015-No0163). ALB, AMG, and MLT
   are members of CONICET.
CR Aghajafari F, 2002, AM J OBSTET GYNECOL, V186, P843, DOI 10.1067/mob.2002.121624
   BARKER DJP, 1993, DIABETOLOGIA, V36, P62, DOI 10.1007/BF00399095
   Barker DJP, 2004, J EPIDEMIOL COMMUN H, V58, P114, DOI 10.1136/jech.58.2.114
   BARKER DJP, 1988, BRIT MED J, V297, P134, DOI 10.1136/bmj.297.6641.134-b
   BARKER DJP, 1986, LANCET, V1, P1077
   Beijers R, 2014, EUR CHILD ADOLES PSY, V23, P943, DOI 10.1007/s00787-014-0566-3
   Boersma GJ, 2014, ENDOCRINOLOGY, V155, P1302, DOI 10.1210/en.2013-1874
   Buhl ES, 2007, AM J PHYSIOL-ENDOC M, V293, pE1451, DOI 10.1152/ajpendo.00356.2007
   Burgueño AL, 2020, INT J OBESITY, V44, P1, DOI 10.1038/s41366-019-0423-z
   Bussières EL, 2015, DEV REV, V36, P179, DOI 10.1016/j.dr.2015.04.001
   Cao-Lei L, 2020, NEUROSCI BIOBEHAV R, V117, P198, DOI 10.1016/j.neubiorev.2017.05.016
   Cleasby ME, 2003, ENDOCRINOLOGY, V144, P999, DOI 10.1210/en.2002-220559
   Crowther CA, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003935.pub4
   Dearden L, 2018, MOL METAB, V15, P8, DOI 10.1016/j.molmet.2018.04.007
   Dodic M, 1998, CLIN SCI, V94, P149, DOI 10.1042/cs0940149
   Doyle LW, 2000, CLIN SCI, V98, P137, DOI 10.1042/CS19990211
   Entringer S, 2015, PSYCHONEUROENDOCRINO, V62, P366, DOI 10.1016/j.psyneuen.2015.08.019
   Entringer S, 2010, CURR OPIN ENDOCRINOL, V17, P507, DOI 10.1097/MED.0b013e3283405921
   Eriksson JG, 2005, MATERN CHILD NUTR, V1, P149, DOI 10.1111/j.1740-8709.2005.00017.x
   Farr OM, 2014, METABOLISM, V63, P1463, DOI 10.1016/j.metabol.2014.08.009
   Gerardin DCC, 2005, PHYSIOL BEHAV, V84, P97, DOI 10.1016/j.physbeh.2004.10.014
   Golubeva AV, 2015, PSYCHONEUROENDOCRINO, V60, P58, DOI 10.1016/j.psyneuen.2015.06.002
   Harris A, 2011, HORM BEHAV, V59, P279, DOI 10.1016/j.yhbeh.2010.06.007
   Higgins JP, 2003, BMJ (Clinical research ed), V327, P557, DOI DOI 10.1136/BMJ.327.7414.557
   HOLSON RR, 1995, NEUROTOXICOL TERATOL, V17, P393, DOI 10.1016/0892-0362(94)00074-N
   Hougaard KS, 2005, NEUROTOXICOL TERATOL, V27, P153, DOI 10.1016/j.ntt.2004.08.001
   Igosheva N, 2004, J PHYSIOL-LONDON, V557, P273, DOI 10.1113/jphysiol.2003.056911
   Igosheva N, 2007, J PHYSIOL-LONDON, V582, P665, DOI 10.1113/jphysiol.2007.130252
   Jaggi AS, 2011, NEUROL SCI, V32, P993, DOI 10.1007/s10072-011-0770-6
   Jimenez-Chillaron Josep C, 2007, Curr Opin Endocrinol Diabetes Obes, V14, P23, DOI 10.1097/MED.0b013e328013da8e
   Kelishadi R, 2015, PAEDIATR INT CHILD H, V35, P110, DOI 10.1179/2046905514Y.0000000136
   Kemp MW, 2016, HUM REPROD UPDATE, V22, P240, DOI 10.1093/humupd/dmv047
   Krolow R, 2013, METABOLISM, V62, P1268, DOI 10.1016/j.metabol.2013.04.009
   Levy-Marchal C, 2004, PEDIATR DIABETES, V5, P147, DOI 10.1111/j.1399-543X.2004.00057.x
   Liberati A., 2009, PLoS Med, V62, P1, DOI [DOI 10.1371/JOURNAL.PMED.1000097, 10.1016/j.jclinepi.2009.06.006]
   Littleton HL, 2010, J PSYCHOSOM OBST GYN, V31, P219, DOI 10.3109/0167482X.2010.518776
   Maccari S, 2003, NEUROSCI BIOBEHAV R, V27, P119, DOI 10.1016/S0149-7634(03)00014-9
   Mark PJ, 2014, REPROD BIOL ENDOCRIN, V12, DOI 10.1186/1477-7827-12-39
   Paternain L, 2013, STRESS, V16, P220, DOI 10.3109/10253890.2012.707708
   Paternain L, 2012, NEUROENDOCRINOLOGY, V96, P249, DOI 10.1159/000341684
   Pervanidou P, 2012, METABOLISM, V61, P611, DOI 10.1016/j.metabol.2011.10.005
   Reynolds RM, 2010, J STEROID BIOCHEM, V122, P3, DOI 10.1016/j.jsbmb.2010.01.009
   Sheen JM, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17040533
   Sreetharan S, 2019, INT J RADIAT BIOL, V95, P1085, DOI 10.1080/09553002.2019.1589025
   Sun D., 2019, J TEXT SCI FASH TECH, DOI [DOI 10.33552/JTSFT.2019.02.000535, 10.33552/jtsft.2019.02.000535]
   Tamashiro KLK, 2009, DIABETES, V58, P1116, DOI 10.2337/db08-1129
   Tellechea ML, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-05344-7
   Tsai CC, 2019, LIPIDS HEALTH DIS, V18, DOI 10.1186/s12944-019-0963-1
   Welberg LAM, 2001, NEUROSCIENCE, V104, P71, DOI 10.1016/S0306-4522(01)00065-3
   Woods LL, 2005, AM J PHYSIOL-REG I, V289, pR955, DOI 10.1152/ajpregu.00455.2004
   Woods LL, 2006, AM J PHYSIOL-REG I, V291, pR1069, DOI 10.1152/ajpregu.00753.2005
   Zambrano E, 2016, ARCH MED RES, V47, P1, DOI 10.1016/j.arcmed.2016.01.004
NR 52
TC 20
Z9 23
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAR
PY 2020
VL 113
AR 104560
DI 10.1016/j.psyneuen.2019.104560
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA LD3MV
UT WOS:000525937600022
PM 31884321
OA Green Published
DA 2025-06-11
ER

PT J
AU Flores-Fuentes, N
   Hernandez-Cruz, C
   Bermeo, K
   Barajas-Martinez, A
   Hernandez-Serratos, VN
   Aceves-Rodriguez, EM
   Martinez-Alonso, E
   Castro, H
   Martinez-Huerta, MI
   Elias-Viñas, D
   Salazar-Anguiano, J
   Arenas, I
   Garcia, DE
AF Flores-Fuentes, Nayely
   Hernandez-Cruz, Carolina
   Bermeo, Karina
   Barajas-Martinez, Antonio
   Nayely Hernandez-Serratos, Valeria
   Mauricio Aceves-Rodriguez, Erick
   Martinez-Alonso, Eduardo
   Castro, Hector
   Irel Martinez-Huerta, Maricela
   Elias-Vinas, David
   Salazar-Anguiano, Jeny
   Arenas, Isabel
   Garcia, David E.
TI Motor learning impairment in rats under a high sucrose diet
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Rotarod; Open field test; Elevated plus-maze; Anxiety-like behavior;
   TNF-alpha
ID METABOLIC SYNDROME; MEMORY-SYSTEMS; BRAIN; BEHAVIOR; COORDINATION;
   LESIONS; SKILL; ACQUISITION; OBESITY; STRESS
AB Motor learning skills are reliable indicators of behavioral acquisition and cognitive disorders. The ease with which learning skills are measured disparities the complexity of the interpretation concerning neural plasticity. Conversely, a wealth of information regarding metabolic derangements has long been reported with direct connection to high sucrose diets. However, the impact of excessive sucrose consumption on undergoing cognitive processes has been only scarcely addressed up to now. Therefore, the goal of this work was to describe the associative relationship between high sucrose consumption and changes in motor learning skills acquisition. Motor learning impairments conditioned by central alterations are hypothesized. Rotarod, elevated plus-maze and open field trials, along with metabolic and pro-inflammatory biomarkers tests in Wistar rats under a high sucrose treatment, were performed. Motor learning impairment in high sucrose diet-treated rats was found while spontaneous locomotor activity remained unchanged. Even though, no anxiety-like behavior under high sucrose diet-treatment was observed. Consistently, the worst outcome in the glucose tolerance test was developed, the worst motor learning performance was observed. Furthermore, insulin resistance correlated positively with a pro-inflammatory state and a decreased latency to fall in the rotarod test. Indeed, C-reactive protein and tumor necrosis factor-alpha serum levels, along with the homeostasis model assessment of insulin resistance (HOMA-IR), significantly increased in motor learning impairment. Together, these results support behavioral, metabolic and pro-inflammatory changes associated with deleterious changes in central nervous system likely involving crucial motor learning structures. Underlying pro-inflammatory-triggered processes may explain cognitive disorders in advanced states of metabolic derangements.
C1 [Flores-Fuentes, Nayely; Hernandez-Cruz, Carolina; Bermeo, Karina; Barajas-Martinez, Antonio; Nayely Hernandez-Serratos, Valeria; Mauricio Aceves-Rodriguez, Erick; Martinez-Alonso, Eduardo; Castro, Hector; Irel Martinez-Huerta, Maricela; Arenas, Isabel; Garcia, David E.] Univ Nacl Autonoma Mexico, Sch Med, Dept Physiol, POB 70250, Mexico City 04510, DF, Mexico.
   [Elias-Vinas, David; Salazar-Anguiano, Jeny] Inst Politecn Nacl, Dept Elect Engn, Sect Bioelect, Ctr Invest & Estudios Avanzados, POB 14740, Mexico City 07000, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico; CINVESTAV - Centro de
   Investigacion y de Estudios Avanzados del Instituto Politecnico
   Nacional; Instituto Politecnico Nacional - Mexico
RP Garcia, DE (corresponding author), Univ Nacl Autonoma Mexico, Sch Med, Dept Physiol, POB 70250, Mexico City 04510, DF, Mexico.
EM erasmo@unam.mx
RI Arenas, Isabel/A-7622-2008; Bermeo, Karina/MFH-2144-2025; Garcia,
   David/AAE-8176-2020; Barajas-Martinez, Antonio/GLR-1196-2022
OI Flores-Fuentes, Nayely/0000-0002-0354-9715; Bermeo,
   Karina/0000-0003-3274-1412; Barajas-Martinez,
   Antonio/0000-0002-5299-0259
FU Alexander von Humboldt Stiftung, Germany [IN216119]; Consejo Nacional de
   Ciencia y Tecnologia (CONACyT) [255635]; Academy of Finland (AKA)
   [255635] Funding Source: Academy of Finland (AKA)
FX This work was supported by the Alexander von Humboldt Stiftung, Germany
   to DEG, UNAM-DGAPA-PAPIIT [grant number IN216119], and Consejo Nacional
   de Ciencia y Tecnologia (CONACyT) [grant number 255635]. We thank Ing.
   Esteban Ruiz Hernandez for electronic support. Dr. Maria De La Luz
   Navarro from the Department of Physiology, School of Medicine, UNAM, for
   providing one of the rotarod equipment.
CR Aguilera AA, 2004, J NUTR BIOCHEM, V15, P350, DOI 10.1016/j.jnutbio.2003.12.008
   Ahmed S, 2014, NEUROCHEM RES, V39, P815, DOI 10.1007/s11064-014-1274-6
   Avena NM, 2008, NEUROSCI BIOBEHAV R, V32, P20, DOI 10.1016/j.neubiorev.2007.04.019
   Bermeo K, 2020, AM J PHYSIOL-ENDOC M, V319, pE1112, DOI 10.1152/ajpendo.00299.2020
   Buitrago MM, 2004, NEUROBIOL LEARN MEM, V81, P211, DOI 10.1016/j.nlm.2004.01.001
   Cacho J, 2008, AM J PHYSIOL-ENDOC M, V295, pE1269, DOI 10.1152/ajpendo.90207.2008
   CORNISH BH, 1992, NUTR RES, V12, P657, DOI 10.1016/S0271-5317(05)80035-1
   Cortés-Reyes Édgar, 2010, Rev. colomb. obstet. ginecol., V61, P247
   Darcet F, 2014, FRONT BEHAV NEUROSCI, V8, DOI 10.3389/fnbeh.2014.00136
   Della Corte KW, 2018, NUTRIENTS, V10, DOI 10.3390/nu10050606
   Dinel AL, 2014, PSYCHONEUROENDOCRINO, V40, P48, DOI 10.1016/j.psyneuen.2013.10.014
   DiNicolantonio JJ, 2018, PROG CARDIOVASC DIS, V61, P3, DOI 10.1016/j.pcad.2017.12.001
   El Hafidi M, 2001, J NUTR BIOCHEM, V12, P396, DOI 10.1016/S0955-2863(01)00154-1
   Eudave DM, 2018, NEUROBIOL STRESS, V9, P1, DOI 10.1016/j.ynstr.2018.05.005
   Felger JC, 2020, MOL PSYCHIATR, V25, P1301, DOI 10.1038/s41380-018-0096-3
   Ferreira A, 2018, NEUROBIOL LEARN MEM, V155, P197, DOI 10.1016/j.nlm.2018.07.014
   Francis H, 2013, APPETITE, V63, P119, DOI 10.1016/j.appet.2012.12.018
   Ghosh S, 2019, INDIAN J MED RES, V149, P610, DOI 10.4103/ijmr.IJMR_2120_18
   Graybiel AM, 1998, NEUROBIOL LEARN MEM, V70, P119, DOI 10.1006/nlme.1998.3843
   Graybiel AM, 1995, CURR OPIN NEUROBIOL, V5, P733, DOI 10.1016/0959-4388(95)80100-6
   Gutierrez R, 2020, CELL MOL LIFE SCI, V77, P3469, DOI 10.1007/s00018-020-03458-2
   Hsu TM, 2015, HIPPOCAMPUS, V25, P227, DOI 10.1002/hipo.22368
   Jameel F, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-195
   Jeljeli M, 1999, BEHAV BRAIN RES, V102, P61, DOI 10.1016/S0166-4328(98)00162-4
   Jeljeli M, 2000, NEUROSCI RES, V38, P155, DOI 10.1016/S0168-0102(00)00152-8
   Joyal CC, 1996, BRAIN RES, V739, P1, DOI 10.1016/S0006-8993(96)00333-2
   Kanazawa M, 2003, NUTR REV, V61, pS27, DOI 10.1301/nr.2003.may.S27-S33
   Knowlton BJ, 1996, SCIENCE, V273, P1399, DOI 10.1126/science.273.5280.1399
   Koebnick C, 2018, BRIT J NUTR, V120, P1230, DOI 10.1017/S0007114518002726
   Koenig S, 2014, BRAIN BEHAV IMMUN, V36, P128, DOI 10.1016/j.bbi.2013.10.019
   Larqué C, 2011, IUBMB LIFE, V63, P831, DOI 10.1002/iub.544
   Luc K, 2019, J PHYSIOL PHARMACOL, V70, P809, DOI 10.26402/jpp.2019.6.01
   MCDONALD RJ, 1993, BEHAV NEUROSCI, V107, P3, DOI 10.1037/0735-7044.107.1.3
   Nakajima S, 2020, INT J OBESITY, V44, P727, DOI 10.1038/s41366-019-0468-z
   Ogura T, 2005, NEUROSCI RES, V51, P299, DOI 10.1016/j.neures.2004.12.006
   Oron-Herman M, 2008, AM J HYPERTENS, V21, P1018, DOI 10.1038/ajh.2008.218
   Pan W, 2002, EXP NEUROL, V174, P193, DOI 10.1006/exnr.2002.7871
   PITSIKAS N, 1990, NEUROBIOL AGING, V11, P417, DOI 10.1016/0197-4580(90)90008-N
   Rada P, 2005, NEUROSCIENCE, V134, P737, DOI 10.1016/j.neuroscience.2005.04.043
   Rebolledo-Solleiro Daniela, 2017, PLoS One, V12, pe0176554, DOI 10.1371/journal.pone.0176554
   Rhea EM, 2017, AAPS J, V19, P921, DOI 10.1208/s12248-017-0079-3
   Rodríguez-Correa E, 2020, NUTR DIABETES, V10, DOI 10.1038/s41387-020-0127-4
   Rojas-Carvajal M, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00674
   Rutter K, 1998, LAB ANIM, V32, P65, DOI 10.1258/002367798780559356
   SALMON DP, 1995, CURR OPIN NEUROBIOL, V5, P184, DOI 10.1016/0959-4388(95)80025-5
   Santos CJ, 2018, NUTR NEUROSCI, V21, P33, DOI 10.1080/1028415X.2016.1213529
   Pinto BAS, 2016, METAB BRAIN DIS, V31, P917, DOI 10.1007/s11011-016-9830-1
   Shiotsuki H, 2010, J NEUROSCI METH, V189, P180, DOI 10.1016/j.jneumeth.2010.03.026
   Small DM, 2017, FRONT NEUROSCI-SWITZ, V11, DOI 10.3389/fnins.2017.00134
   Kruse MS, 2019, PSYCHONEUROENDOCRINO, V104, P300, DOI 10.1016/j.psyneuen.2019.03.016
   SPECTOR AC, 1984, PHYSIOL BEHAV, V33, P127, DOI 10.1016/0031-9384(84)90023-4
   Swinburn BA, 2011, LANCET, V378, P804, DOI 10.1016/S0140-6736(11)60813-1
   van den Brom CE, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/5205631
   Wang CM, 2016, NEURAL PLAST, V2016, DOI 10.1155/2016/2473081
   White NM, 1997, CURR OPIN NEUROBIOL, V7, P164, DOI 10.1016/S0959-4388(97)80004-9
   White NM, 2002, NEUROBIOL LEARN MEM, V77, P125, DOI 10.1006/nlme.2001.4008
   Yin HH, 2009, NAT NEUROSCI, V12, P333, DOI 10.1038/nn.2261
NR 57
TC 8
Z9 8
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
EI 1873-507X
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD MAY 15
PY 2021
VL 234
AR 113384
DI 10.1016/j.physbeh.2021.113384
EA MAR 2021
PG 9
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA RN2MU
UT WOS:000640186900010
PM 33676960
DA 2025-06-11
ER

PT J
AU Wu, Q
   Hua, YY
   Ma, QH
   Xu, Y
   Chen, X
   Pan, CW
AF Wu, Qian
   Hua, Yi-Ying
   Ma, Qing-Hua
   Xu, Yong
   Chen, Xing
   Pan, Chen-Wei
TI Depressive symptoms and 5-year incident metabolic syndrome among older
   adults
SO SCIENTIFIC REPORTS
LA English
DT Article
ID BLOOD-PRESSURE; ASSOCIATION; ANXIETY; RISK; HEALTH; TEA; HYPERTENSION;
   METAANALYSIS; PREVALENCE; DISEASE
AB Little is known regarding the association between depressive symptoms and metabolic syndrome (MetS) among older Chinese adults. This study aimed to examine the association of depressive symptoms with MetS and its components among Chinese elderly. Based on whether they showed depressive symptoms at baseline, 262 age-gender-matched participants from a community-based cohort study were included. The presence of depressive symptoms was measured using the nine-item Patient Health Questionnaire (PHQ-9). MetS was defined according to the Adult Treatment Panel III of the National Cholesterol Education Program. Linear regression and logistic regression analyses were performed to assess associations of depressive symptoms with MetS and its components. The incidence of MetS among the participants with depressive symptoms at baseline was 15.27% (20/131). The association of the presence of depressive symptoms with MetS was significant (odds ratio [OR] = 2.53, 95% confidence intervals [CI] = 1.07, 5.95). There was a negative association between depressive symptoms and hypertension (OR = 0.04, 95% CI = 0.002, 0.98). The change in mean arterial pressure varies approximately 1.03 mmHg with a 1-point change in PHQ-9 score. In this study, baseline depressive symptoms were associated with subsequent MetS. The presence of depressive symptoms was negatively associated with elevated mean arterial pressure.
C1 [Wu, Qian; Hua, Yi-Ying; Xu, Yong; Pan, Chen-Wei] Soochow Univ, Sch Publ Hlth, Med Coll, 199 Ren Ai Rd, Suzhou 215123, Peoples R China.
   [Ma, Qing-Hua] 3rd Peoples Hosp Xiangcheng Dist, Suzhou, Peoples R China.
   [Chen, Xing] Nanjing Med Univ, Affiliated Suzhou Hosp, Dept Children Hlth Care, 26 Dao Qian Rd, Suzhou 215000, Peoples R China.
C3 Soochow University - China; Nanjing Medical University
RP Pan, CW (corresponding author), Soochow Univ, Sch Publ Hlth, Med Coll, 199 Ren Ai Rd, Suzhou 215123, Peoples R China.; Chen, X (corresponding author), Nanjing Med Univ, Affiliated Suzhou Hosp, Dept Children Hlth Care, 26 Dao Qian Rd, Suzhou 215000, Peoples R China.
EM cx1708@126.com; pcwonly@gmail.com
RI Ma, Qinghua/KPA-8692-2024; Pan, Chen-Wei/L-7174-2019; xing,
   chen/AFQ-8607-2022
FU Science and Technology Bureau of Xiangcheng District in Suzhou, China
   [XJ201706, GSWS2019090]
FX This study was supported by the Science and Technology Bureau of
   Xiangcheng District in Suzhou, China under Grant nos. XJ201706 and
   GSWS2019090.
CR Akbaraly TN, 2011, DIABETES CARE, V34, P904, DOI 10.2337/dc10-1644
   Ortiz-Rodríguez MA, 2017, ARCH GERONTOL GERIAT, V73, P288, DOI 10.1016/j.archger.2017.09.001
   Bakhtiari Afsaneh, 2018, Iran J Psychiatry, V13, P230
   Barba C, 2004, LANCET, V363, P157, DOI 10.1016/s0140-6736(03)15268-3
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   Chu SL, 2011, CHIN J INTEGR MED, V17, P492, DOI 10.1007/s11655-011-0781-4
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Deen JF, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.114.001132
   Denys K, 2009, ACTA CLIN BELG, V64, P23, DOI 10.1179/acb.2009.006
   Dormann CF, 2013, ECOGRAPHY, V36, P27, DOI 10.1111/j.1600-0587.2012.07348.x
   Feinkohl I, 2019, BMC GERIATR, V19, DOI 10.1186/s12877-019-1073-7
   Goldbacher EM, 2007, ANN BEHAV MED, V34, P240, DOI 10.1007/BF02874549
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Gong YH, 2012, INT PSYCHOGERIATR, V24, P1226, DOI 10.1017/S1041610211002663
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Hildrum B, 2009, ACTA PSYCHIAT SCAND, V120, P14, DOI 10.1111/j.1600-0447.2008.01315.x
   Hsu CH, 2015, PREV MED, V72, P76, DOI 10.1016/j.ypmed.2014.12.036
   Jenkins AIC, 2020, J FAM PSYCHOL, V34, P12, DOI 10.1037/fam0000573
   Jonas BS, 1997, ARCH FAM MED, V6, P43, DOI 10.1001/archfami.6.1.43
   Kiama CN, 2018, PAN AFR MED J, V29, DOI 10.11604/pamj.2018.29.90.13328
   Kim EY, 2015, J AFFECT DISORDERS, V188, P14, DOI 10.1016/j.jad.2015.08.024
   Kroenke K, 2012, CAN MED ASSOC J, V184, P281, DOI 10.1503/cmaj.112004
   Kroenke K, 2010, GEN HOSP PSYCHIAT, V32, P345, DOI 10.1016/j.genhosppsych.2010.03.006
   Lambert E, 2010, J HYPERTENS, V28, P543, DOI 10.1097/HJH.0b013e3283350ea4
   Li HB, 2019, JAMA NETW OPEN, V2, DOI 10.1001/jamanetworkopen.2019.16591
   Lu JL, 2017, J CLIN ENDOCR METAB, V102, P507, DOI 10.1210/jc.2016-2477
   Luppa M, 2012, J AFFECT DISORDERS, V136, P212, DOI 10.1016/j.jad.2010.11.033
   Matta J, 2019, J AFFECT DISORDERS, V244, P25, DOI 10.1016/j.jad.2018.09.072
   Meng L, 2012, J HYPERTENS, V30, P842, DOI 10.1097/HJH.0b013e32835080b7
   Morikawa M, 2013, INT J GERIATR PSYCH, V28, P1251, DOI 10.1002/gps.3950
   Moussavi S, 2007, LANCET, V370, P851, DOI 10.1016/S0140-6736(07)61415-9
   Muldoon MF, 2006, J CLIN ENDOCR METAB, V91, P718, DOI 10.1210/jc.2005-1654
   Nouwen A, 2019, DIABETIC MED, V36, P1562, DOI 10.1111/dme.14054
   O'Brien EC, 2015, CIRC-CARDIOVASC QUAL, V8, P552, DOI 10.1161/CIRCOUTCOMES.115.001800
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Panza F, 2011, CURR ALZHEIMER RES, V8, P492, DOI 10.2174/156720511796391818
   Pérez-de la Cruz S, 2019, ACTA NEUROL BELG, V119, P193, DOI 10.1007/s13760-018-1034-5
   Plana-Ripoll O, 2019, LANCET, V394, P1827, DOI 10.1016/S0140-6736(19)32316-5
   Ra Jin Suk, 2017, Osong Public Health Res Perspect, V8, P130, DOI 10.24171/j.phrp.2017.8.2.05
   Ruas LG, 2016, REV BRAS PSIQUIATR, V38, P183, DOI 10.1590/1516-4446-2015-1856
   Scalco Andréia Zavaloni, 2005, Clinics, V60, P241, DOI 10.1590/S1807-59322005000300010
   Scalco MZ, 2003, AM J CARDIOL, V91, P1279, DOI 10.1016/S0002-9149(03)00286-8
   Sheng T, 2016, J REHABIL RES DEV, V53, P781, DOI 10.1682/JRRD.2015.07.0146
   Sin NL, 2016, ANN BEHAV MED, V50, P523, DOI 10.1007/s12160-016-9777-9
   Smarr KL, 2011, ARTHRIT CARE RES, V63, pS454, DOI 10.1002/acr.20556
   Smith TW, 2017, ANN BEHAV MED, V51, P610, DOI 10.1007/s12160-017-9883-3
   Suliga E, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112764
   Tseng TJ, 2019, BMC GERIATR, V19, DOI 10.1186/s12877-019-1079-1
   Weber-Hamann B, 2005, NEUROENDOCRINOLOGY, V81, P200, DOI 10.1159/000087003
   Weber-Hamann B, 2002, PSYCHOSOM MED, V64, P274, DOI 10.1097/00006842-200203000-00010
   Wolfram S, 2007, J AM COLL NUTR, V26, p373S, DOI 10.1080/07315724.2007.10719626
   Wong TY, 2003, HYPERTENSION, V41, P1086, DOI 10.1161/01.HYP.0000064181.63546.53
   Yin JY, 2017, J NUTR HEALTH AGING, V21, P1151, DOI 10.1007/s12603-016-0829-4
   Yu SS, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-016-3913-0
   Zhao DD, 2018, INT PSYCHOGERIATR, V30, P1489, DOI 10.1017/S1041610218000030
NR 55
TC 6
Z9 6
U1 1
U2 9
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUL 21
PY 2021
VL 11
IS 1
AR 14842
DI 10.1038/s41598-021-94503-y
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA UD6MB
UT WOS:000687318300001
PM 34290362
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Méndez, L
   Pazos, M
   Giralt, M
   Nogués, MR
   Pérez-Jiménez, J
   Torres, JL
   Gallardo, JM
   Medina, I
AF Mendez, Lucia
   Pazos, Manuel
   Giralt, Montserrat
   Nogues, M. Rosa
   Perez-Jimenez, Jara
   Torres, Josep L.
   Gallardo, J. M.
   Medina, Isabel
TI Targets of protein carbonylation in spontaneously hypertensive obese
   Koletsky rats and healthy Wistar counterparts: A potential role on
   metabolic disorders
SO JOURNAL OF PROTEOMICS
LA English
DT Article
DE Metabolic syndrome; SHROB model; Wistar rat; Oxidative stress; Redox
   proteomics; Protein carbonylation
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; GRAPE SEED; GENERATION; TISSUE;
   HYPERTRIGLYCERIDEMIA; IDENTIFICATION; CARBOHYDRATE; DYSFUNCTION;
   PROTEOMICS
AB The study innovatively pinpoints target proteins of carbonylation, a key PTM induced by oxidative stress, in the SHROB (genetically obese spontaneously hypertensive) rat model of metabolic syndrome (MetS). Protein carbonylation was assessed by a fluorescence-labeling proteomics approach, and complemented with biometric and biochemical. markers of MetS. SHROB and healthy Wistar rats were fed two diets, soybean and linseed oil supplementations, in order to distinguish intrinsic carbonylation of SHROB animals from diet-modulated carbonylation unrelated to MetS. First exploratory data showed similar carbonylation patterns and metabolic conditions in SHROB rats fed soybean and linseed, but different from Wistar animals. A total of 18 carbonylated spots in liver, and 12 in skeletal tissue, related to pathways of lipid (29.6%), carbohydrate (25.9%) and amino acid (18.5%) metabolisms, were identified. In particular, SHROB animals present higher carbonylation in four liver proteins belonging to lipid metabolism, redox regulation and chaperone activity (ALDH2, PDI, PDIA3, PECR), and in the skeletal muscle ALDOA that is involved in muscle dysfunction. Conversely, SHROB rats display lower carbonylation in liver albumin, AKR1C9, ADH1 and catalase. This investigation provides a novel perspective of carbonylation in the context of metabolic disorders, and maybe a starting point to characterize new redox pathways exacerbating MetS.
   Biological significance
   Oxidative stress is a concomitant factor in the pathogenesis of MetS that induces oxidative PTM as carbonylation. Through the use of a redox proteomics approach, we have thoroughly mapped the occurrence of protein targets of carbonylation in the genetically-induced MetS model SHROB rat. The present research brings anew insight of MetS pathogenesis and it may provide valuable information to understand the biological impact of oxidative stress in patients with MetS. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Mendez, Lucia; Pazos, Manuel; Gallardo, J. M.; Medina, Isabel] CSIC, IIM, E-36208 Vigo, Spain.
   [Perez-Jimenez, Jara; Torres, Josep L.] CSIC, IQAC, E-08034 Barcelona, Spain.
   [Giralt, Montserrat; Nogues, M. Rosa] Univ Rovira & Virgili, Fac Med & Ciencias Salud, Unidad Farmacol, E-43201 Reus, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Investigaciones Marinas (IIM); Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC - Centro de Investigacion y Desarrollo Pascual
   Vila (CID-CSIC); CSIC - Instituto de Quimica Avanzada de Cataluna
   (IQAC); Universitat Rovira i Virgili
RP Pazos, M (corresponding author), CSIC, IIM, Eduardo Cabello 6, E-36208 Vigo, Spain.
EM mpazos@iim.csic.es
RI MEDINA, ISABEL/AAL-4012-2021; Nogués, M./ABH-5645-2020; Perez-Jimenez,
   Jara/B-3989-2009; Torres, Josep/N-7256-2013; Pazos, Manuel/N-5007-2014;
   Mendez, Lucia/T-7016-2017; Montserrat, Giralt/I-3905-2015
OI MEDINA, ISABEL/0000-0002-1854-3359; Torres, Josep/0000-0002-5072-8265;
   Pazos, Manuel/0000-0003-1571-5730; Mendez, Lucia/0000-0002-9711-2994;
   Montserrat, Giralt/0000-0002-7073-577X; Perez-Jimenez,
   Jara/0000-0002-2811-4558
FU Spanish Ministry of Science and Innovation [AGL2009-12374-C03-01, -02,
   -03]; Spanish Ministry of Science and Innovation; USC (Spain);
   postdoctoral "Isidro Parga Pondal"; Instituto de Salud Carlos III
   [CD09/00068]
FX This investigation has been supported by the Spanish Ministry of Science
   and Innovation (Grant AGL2009-12374-C03-01, -02 and -03). The Spanish
   Ministry of Science and Innovation is gratefully acknowledged for the
   doctoral fellowship to L.M. L.M. also thanks the USC (Spain) for its
   doctoral program. Xunta de Galicia and European Social Fund are
   thankfully recognized by the financial support of the postdoctoral
   "Isidro Parga Pondal" contract to M.P. J.P.-J. thanks the Spanish
   Ministry of Science and Innovation and the Instituto de Salud Carlos III
   for granting her a Sara Borrell postdoctoral contract (CD09/00068). The
   authors thank Mrs. Lorena Barros for her excellent technical assistance.
CR Anderson NL, 2002, MOL CELL PROTEOMICS, V1, P845, DOI 10.1074/mcp.R200007-MCP200
   Bachi A, 2013, CHEM REV, V113, P596, DOI 10.1021/cr300073p
   Baiges I, 2010, MOL CELL PROTEOMICS, V9, P1499, DOI 10.1074/mcp.M000055-MCP201
   Barreiro E, 2005, AM J RESP CELL MOL, V32, P9, DOI 10.1165/rcmb.2004-0021OC
   Barreiro E, 2010, ANTIOXID REDOX SIGN, V12, P417, DOI 10.1089/ars.2009.2808
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Cardona F, 2008, CLIN BIOCHEM, V41, P701, DOI 10.1016/j.clinbiochem.2008.03.001
   Charradi K, 2012, NEUROCHEM RES, V37, P2004, DOI 10.1007/s11064-012-0821-2
   Chaudhuri AR, 2006, MECH AGEING DEV, V127, P849, DOI 10.1016/j.mad.2006.08.006
   Chavez J, 2010, CHEM RES TOXICOL, V23, P37, DOI 10.1021/tx9002462
   Chen CH, 2010, CARDIOVASC RES, V88, P51, DOI 10.1093/cvr/cvq192
   COHEN G, 1970, ANAL BIOCHEM, V34, P30, DOI 10.1016/0003-2697(70)90083-7
   Costa WMV, 2002, FREE RADICAL BIO MED, V33, P1507, DOI 10.1016/S0891-5849(02)01086-9
   Curtis JM, 2012, TRENDS ENDOCRIN MET, V23, P399, DOI 10.1016/j.tem.2012.05.008
   Dalle-Donne I, 2003, TRENDS MOL MED, V9, P169, DOI 10.1016/S1471-4914(03)00031-5
   Davies MJ, 2005, BBA-PROTEINS PROTEOM, V1703, P93, DOI 10.1016/j.bbapap.2004.08.007
   Fellmann L, 2013, PHARMACOL THERAPEUT, V137, P331, DOI 10.1016/j.pharmthera.2012.11.004
   Franceschini A, 2013, NUCLEIC ACIDS RES, V41, pD808, DOI 10.1093/nar/gks1094
   Frohnert BI, 2013, ADV NUTR, V4, P157, DOI 10.3945/an.112.003319
   Frohnert BI, 2011, OBESITY, V19, P1735, DOI 10.1038/oby.2011.115
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Grattagliano I, 2008, J NUTR BIOCHEM, V19, P491, DOI 10.1016/j.jnutbio.2007.06.011
   Grimsrud PA, 2007, MOL CELL PROTEOMICS, V6, P624, DOI 10.1074/mcp.M600120-MCP200
   Hawkins CL, 2001, BBA-BIOENERGETICS, V1504, P196, DOI 10.1016/S0005-2728(00)00252-8
   Jensen ON, 1998, PROTEINS, P74
   Khoo NKH, 2012, FREE RADICAL BIO MED, V52, P2312, DOI 10.1016/j.freeradbiomed.2012.04.011
   Marí M, 2010, ANTIOXID REDOX SIGN, V12, P1295, DOI 10.1089/ars.2009.2634
   Méndez L, 2013, FREE RADICAL BIO MED, V55, P8, DOI 10.1016/j.freeradbiomed.2012.11.004
   MISRA HP, 1972, J BIOL CHEM, V247, P3170
   Moller IM, 2011, J PROTEOMICS, V74, P2228, DOI 10.1016/j.jprot.2011.05.004
   Pazos M, 2013, FOOD CHEM, V136, P64, DOI 10.1016/j.foodchem.2012.07.109
   Pazos M, 2011, J AGR FOOD CHEM, V59, P7962, DOI 10.1021/jf201080t
   Pennathur S, 2001, J CLIN INVEST, V107, P853, DOI 10.1172/JCI11194
   Pennathur S, 2007, ANTIOXID REDOX SIGN, V9, P955, DOI 10.1089/ars.2007.1595
   Poudyal H, 2013, J NUTR BIOCHEM, V24, P1041, DOI 10.1016/j.jnutbio.2012.07.014
   PRONAI L, 1991, ATHEROSCLEROSIS, V90, P39, DOI 10.1016/0021-9150(91)90242-U
   Roche M, 2008, FEBS LETT, V582, P1783, DOI 10.1016/j.febslet.2008.04.057
   Ruiz-Ramírez A, 2011, AM J PHYSIOL-ENDOC M, V301, pE1198, DOI 10.1152/ajpendo.00631.2010
   Ruskovska T, 2013, J PROTEOMICS, V92, P323, DOI 10.1016/j.jprot.2013.04.002
   Sies H., 2014, J Biol Chem
   SMITH PK, 1985, ANAL BIOCHEM, V150, P76, DOI 10.1016/0003-2697(85)90442-7
   Su Y, 2008, INT J CLIN PRACT, V62, P877, DOI 10.1111/j.1742-1241.2008.01776.x
   Telci A, 2000, HORM METAB RES, V32, P40, DOI 10.1055/s-2007-978584
   Theodorou M, 2009, FASEB J, V23
   Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
   WHEELER CR, 1990, ANAL BIOCHEM, V184, P193, DOI 10.1016/0003-2697(90)90668-Y
   Wong CM, 2010, ANTIOXID REDOX SIGN, V12, P393, DOI 10.1089/ars.2009.2805
   Xu C, 2008, J NUTR BIOCHEM, V19, P305, DOI 10.1016/j.jnutbio.2007.05.001
NR 48
TC 14
Z9 14
U1 0
U2 20
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1874-3919
EI 1876-7737
J9 J PROTEOMICS
JI J. Proteomics
PD JUN 25
PY 2014
VL 106
BP 246
EP 259
DI 10.1016/j.jprot.2014.04.036
PG 14
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA AK7QB
UT WOS:000338621700019
PM 24793432
DA 2025-06-11
ER

PT J
AU Weiss, C
   Kornicka-Grabowska, K
   Mularczyk, M
   Siwinska, N
   Marycz, K
AF Weiss, C.
   Kornicka-Grabowska, K.
   Mularczyk, M.
   Siwinska, N.
   Marycz, K.
TI Extracellular Microvesicles (MV's) Isolated from
   5-Azacytidine-and-Resveratrol-Treated Cells Improve Viability and
   Ameliorate Endoplasmic Reticulum Stress in Metabolic Syndrome Derived
   Mesenchymal Stem Cells
SO STEM CELL REVIEWS AND REPORTS
LA English
DT Article
DE Stem cells; Extracellular vesicles; Rejuvenation
ID AUTOPHAGY; DEATH; REGENERATION; MECHANISM; PROTECT; TISSUE
AB Extracellular vesicles (EVs), a spherical membrane fragments including exosomes, are released from several cell types, including mesenchymal stromal cells (MSCs), constitutively or under stimulation. As MVs cargo include DNA, RNA, miRNA, lipids and proteins their have gain special attention in the field of regenerative medicine. Depending on the type of transferred molecules, MVs may exert wide range of biological effects in recipient cells including pro-inflammatory and anti-apoptotic action. In presented paper, we isolated MVs form adipose derived mesenchymal stem cells (ASC) which underwent stimulation with 5-azacytydine and resveratrol (AZA/RES) in order to improve their therapeutic potential. Then, isolated MVs were applied to ASC with impaired cytophysiological properties, isolated from equine metabolic syndrome diagnosed animals. Using RT-PCR, immunofluorescence, ELISA, confocal microscopy and western blot, we have evaluated the effects of MVs on recipient cells. We have found, that MVs derived from AZA/RES treated ASC ameliorates apoptosis, senescence and endoplasmic reticulum (ER) stress in deteriorated cells, restoring their proper functions. The work indicates, that cells treated with AZA/RES through their paracrine action can rejuvenate recipient cells. However, further research needs to be performed in order to fully understand the molecular mechanisms of these bioactive factors action.
C1 [Weiss, C.] PferdePraxis Dr Med Vet Daniel Weiss, Postmatte 14, CH-8807 Freienbach, Switzerland.
   [Kornicka-Grabowska, K.; Mularczyk, M.; Marycz, K.] Wroclaw Univ Environm & Life Sci, Dept Expt Biol, Norwida 27B St,A7 Bldg, PL-50375 Wroclaw, Poland.
   [Kornicka-Grabowska, K.; Mularczyk, M.; Marycz, K.] Int Inst Translat Med, Jesionowa 11, PL-55114 Wisznia Mala, Poland.
   [Siwinska, N.] Wroclaw Univ Environm & Life Sci, Fac Vet Med, Dept Internal Med & Clin Dis Horses Dogs & Cats, Pl Grunwaldzki 47, PL-50366 Wroclaw, Poland.
   [Marycz, K.] Justus Liebig Univ, Fac Vet Med, Equine Clin Equine Surg, D-35392 Giessen, Germany.
C3 Wroclaw University of Environmental & Life Sciences; Wroclaw University
   of Environmental & Life Sciences; Justus Liebig University Giessen
RP Marycz, K (corresponding author), Wroclaw Univ Environm & Life Sci, Dept Expt Biol, Norwida 27B St,A7 Bldg, PL-50375 Wroclaw, Poland.; Marycz, K (corresponding author), Int Inst Translat Med, Jesionowa 11, PL-55114 Wisznia Mala, Poland.; Marycz, K (corresponding author), Justus Liebig Univ, Fac Vet Med, Equine Clin Equine Surg, D-35392 Giessen, Germany.
EM krzysztofmarycz@interia.pl
FU grant "Modulation mitochondrial metabolism and dynamics and targeting
   DNA methylation of adipose derived mesenchymal stromal stem cell (ASC)
   using resveratrol and 5-azacytydin as a therapeutic strategy in the
   course of Equine metabolic syndrome (EMS)" by T [2016/21/B/NZ7/01111];
   grant "Inhibition of tyrosine phosphatase as a strategy to enhance
   insulin sensitivity through activation of chaperone mediated autophagy
   and amelioration of inflammation and cellular stress in the liver of
   equinemetabolic syndrome (EMS) horses" by The Nat [2018/29/B/NZ7/02662]
FX This project was financed within the framework of a grants entitled
   "Modulation mitochondrial metabolism and dynamics and targeting DNA
   methylation of adipose derived mesenchymal stromal stem cell (ASC) using
   resveratrol and 5-azacytydin as a therapeutic strategy in the course of
   Equine metabolic syndrome (EMS)." (grant no. 2016/21/B/NZ7/01111) and
   "Inhibition of tyrosine phosphatase as a strategy to enhance insulin
   sensitivity through activation of chaperone mediated autophagy and
   amelioration of inflammation and cellular stress in the liver of
   equinemetabolic syndrome (EMS) horses." (grant no. 2018/29/B/NZ7/02662)
   financed by The National Science Centre in Poland.
CR Akyurekli C, 2015, STEM CELL REV REP, V11, P150, DOI 10.1007/s12015-014-9545-9
   Alicka M, 2019, J CLIN MED, V8, DOI 10.3390/jcm8060765
   Alicka M, 2018, STEM CELLS INT, V2018, DOI 10.1155/2018/4274361
   [Anonymous], 2020, THER MES STROM STEM, DOI DOI 10.1007/S12015-019-09932-0
   [Anonymous], 2016, OXID MED CELL LONGEV
   Ariyasu D, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18020382
   Basinska K, 2015, J VET SCI, V16, P113, DOI [10.4142/jvs.2015.16.1.113, 10.4142/jvs.2015.16.1.107]
   Biancone L, 2012, NEPHROL DIAL TRANSPL, V27, P3037, DOI 10.1093/ndt/gfs168
   Boh��ov�� P., 2018, Vnitr Lek, V64, P725
   Bruno S, 2009, J AM SOC NEPHROL, V20, P1053, DOI 10.1681/ASN.2008070798
   Camussi G, 2010, KIDNEY INT, V78, P838, DOI 10.1038/ki.2010.278
   Caramés B, 2010, ARTHRITIS RHEUM-US, V62, P791, DOI 10.1002/art.27305
   Chen J, 2020, STEM CELL RES THER, V11, DOI 10.1186/s13287-020-01610-0
   Cislo-Pakuluk A, 2017, STEM CELL REV REP, V13, P598, DOI 10.1007/s12015-017-9750-4
   Collino F, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011803
   Frank N, 2009, J EQUINE VET SCI, V29, P259, DOI 10.1016/j.jevs.2009.04.183
   Green DR, 2014, CELL, V157, P65, DOI 10.1016/j.cell.2014.02.049
   Harrell CR, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8121605
   Herrera MB, 2010, J CELL MOL MED, V14, P1605, DOI 10.1111/j.1582-4934.2009.00860.x
   Honoki K, 2017, WORLD J STEM CELLS, V9, P1, DOI 10.4252/wjsc.v9.i1.1
   Hosseinkhani B, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01789
   Jiang XF, 2018, CURR PHARM DESIGN, V24, P5334, DOI 10.2174/1381612825666190119130441
   Karamini A, 2020, STEM CELL REV REP, V16, P276, DOI 10.1007/s12015-020-09954-z
   Kornicka K, 2019, J CELL MOL MED, V23, P237, DOI 10.1111/jcmm.13914
   Kornicka K, 2018, J CLIN MED, V7, DOI 10.3390/jcm7110383
   Kornicka K, 2018, STEM CELL REV REP, V14, P337, DOI 10.1007/s12015-018-9809-x
   Kornicka K, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/309169
   Kornicka-Garbowska K, 2019, STEM CELL RES THER, V10, DOI 10.1186/s13287-019-1469-5
   Liao ZW, 2019, THERANOSTICS, V9, P4084, DOI 10.7150/thno.33638
   Maredziak M, 2015, STEM CELLS INT, V2015, DOI 10.1155/2015/379093
   Marycz K., 2012, VET MED
   Marycz K, 2019, STEM CELL REV REP, V15, P842, DOI 10.1007/s12015-019-09913-3
   Marycz K, 2018, J CELL MOL MED, V22, P4771, DOI 10.1111/jcmm.13731
   Marycz K, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/3718468
   Marycz K, 2016, STEM CELLS INT, V2016, DOI 10.1155/2016/5756901
   Merlo B, 2018, STEM CELL REV REP, V14, P574, DOI 10.1007/s12015-018-9803-3
   Nawrocka D, 2017, MAR DRUGS, V15, DOI 10.3390/md15080237
   Pileggi A, 2012, DIABETES, V61, P1355, DOI 10.2337/db12-0355
   Radziszewska A, 2009, J BIOL CHEM, V284, P10947, DOI 10.1074/jbc.M806960200
   Ratajczak J, 2006, LEUKEMIA, V20, P1487, DOI 10.1038/sj.leu.2404296
   Ratajczak J, 2006, LEUKEMIA, V20, P847, DOI 10.1038/sj.leu.2404132
   Rogers Christopher S, 2016, Curr Protoc Hum Genet, V90, DOI 10.1002/cphg.18
   Stolzing A, 2008, MECH AGEING DEV, V129, P163, DOI 10.1016/j.mad.2007.12.002
   Szatanek R, 2015, INT J MOL MED, V36, P11, DOI 10.3892/ijmm.2015.2194
   Telugu BPVL, 2010, STEM CELL REV REP, V6, P31, DOI 10.1007/s12015-009-9101-1
   Wang MJ, 2019, AGING DIS, V10, P871, DOI 10.14336/AD.2018.1119
   Zafardoust S, 2020, STEM CELL REV REP, V16, P755, DOI 10.1007/s12015-020-09969-6
NR 47
TC 15
Z9 15
U1 0
U2 13
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2629-3269
EI 2629-3277
J9 STEM CELL REV REP
JI Stem Cell Rev. Rep.
PD DEC
PY 2020
VL 16
IS 6
BP 1343
EP 1355
DI 10.1007/s12015-020-10035-4
EA SEP 2020
PG 13
WC Cell & Tissue Engineering; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA OR7EN
UT WOS:000565828800002
PM 32880856
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Peleli, M
   Ferreira, DMS
   Tarnawski, L
   Haworth, SM
   Xuechen, L
   Zhuge, Z
   Newton, PT
   Massart, J
   Chagin, AS
   Olofsson, PS
   Ruas, JL
   Weitzberg, E
   Lundberg, JO
   Carlström, M
AF Peleli, M.
   Ferreira, D. M. S.
   Tarnawski, L.
   Haworth, S. McCann
   Xuechen, L.
   Zhuge, Z.
   Newton, P. T.
   Massart, J.
   Chagin, A. S.
   Olofsson, P. S.
   Ruas, J. L.
   Weitzberg, E.
   Lundberg, J. O.
   Carlstrom, M.
TI Dietary nitrate attenuates high-fat diet-induced obesity via mechanisms
   involving higher adipocyte respiration and alterations in inflammatory
   status
SO REDOX BIOLOGY
LA English
DT Article
DE Inorganic nitrate; Metabolic syndrome; Mitochondria; Visceral fat;
   Inflammation; Thermogenesis
ID INORGANIC NITRATE; NITRIC-OXIDE; ADIPOSE-TISSUE; ACTIVATED MACROPHAGES;
   OXIDATIVE STRESS; MICE; THERMOGENESIS; MODULATION; REDUCTION
AB Emerging evidence indicates that dietary nitrate can reverse several features of the metabolic syndrome, but the underlying molecular mechanisms still remain elusive. The aim of the present study was to explore mechanisms involved in the effects of dietary nitrate on the metabolic dysfunctions induced by high-fat diet (HFD) in mice. Four weeks old C57BL/6 male mice, exposed to HFD for ten weeks, were characterised by increased body weight, fat content, increased fasting glucose and impaired glucose clearance. All these metabolic abnormalities were significantly attenuated by dietary nitrate. Mechanistically, subcutaneous primary mouse adipocytes exposed to palmitate (PA) and treated with nitrite exhibited higher mitochondrial respiration, increased protein expression of total mitochondrial complexes and elevated gene expression of the thermogenesis gene UCP-1, as well as of the creatine transporter SLC6A8. Finally, dietary nitrate increased the expression of anti-inflammatory markers in visceral fat, plasma and bone marrow-derived macrophages (Arginase-1, Egr-2, IL-10), which was associated with reduction of NADPH oxidase-derived superoxide production in macrophages. In conclusion, dietary nitrate may have therapeutic utility against obesity and associated metabolic complications possibly by increasing adipocyte mitochondrial respiration and by dampening inflammation and oxidative stress.
C1 [Peleli, M.; Ferreira, D. M. S.; Haworth, S. McCann; Xuechen, L.; Zhuge, Z.; Newton, P. T.; Chagin, A. S.; Ruas, J. L.; Weitzberg, E.; Lundberg, J. O.; Carlstrom, M.] Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.
   [Tarnawski, L.; Olofsson, P. S.] Karolinska Inst, Ctr Mol Med, Dept Med, Stockholm, Sweden.
   [Tarnawski, L.; Olofsson, P. S.] Karolinska Univ Hosp, Stockholm, Sweden.
   [Massart, J.] Karolinska Inst, Dept Mol Med & Surg Integrat Physiol, S-17177 Stockholm, Sweden.
   [Chagin, A. S.] Sechenov Univ, Inst Regenerat Med, Moscow, Russia.
   [Weitzberg, E.] Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.
C3 Karolinska Institutet; Karolinska Institutet; Karolinska Institutet;
   Karolinska University Hospital; Karolinska Institutet; Sechenov First
   Moscow State Medical University; Karolinska Institutet
RP Carlström, M (corresponding author), Karolinska Inst, Biomedicum, Dept Physiol & Pharmacol, 5B,Solnavagen 9, S-17165 Solna, Sweden.
EM mattias.carlstrom@ki.se
RI Massart, Julie/AAA-3077-2019; Peleli, Maria/AAQ-2326-2021; Tarnawski,
   Laura/ABB-1979-2020; Chagin, Andrei/F-4080-2014; Sacramento Ferreira,
   Duarte Miguel/E-4270-2012; Carlstrom, Mattias/E-7350-2015; Ruas,
   Jorge/T-3040-2017
OI Chagin, Andrei/0000-0002-2696-5850; Tarnawski,
   Laura/0000-0001-7993-0232; Newton, Phillip/0000-0003-2142-1798; McCann
   Haworth, Sarah/0000-0002-4299-5486; Lundberg, Jon/0000-0002-0174-5210;
   Sacramento Ferreira, Duarte Miguel/0000-0001-5940-7102; Carlstrom,
   Mattias/0000-0001-9923-8729; Massart, Julie/0000-0001-8213-5459; Ruas,
   Jorge/0000-0002-1110-2606
FU Swedish Research Council [2016-01381, 2016-00785]; Swedish Heart and
   Lung Foundation [20140448, 20170124]; Novo Nordisk [0055026]; EFSD/Lilly
   European Diabetes Research Programme [97012]; Karolinska Institutet,
   Stockholm, Sweden [2-560/2015]; KID funding from the Karolinska
   Institutet, Stockholm, Sweden [2-3707/2013, 2-1930/2016]; Swedish
   Research Council [2016-00785] Funding Source: Swedish Research Council
FX We thank Carina Nihlen, Annika Olsson, Margareta Stensdotter (Karolinska
   Institutet, Stockholm, Sweden) for their technical assistance. Marie
   Bjornholm, Anna Krook and the Animal metabolic research facility at the
   Strategic Research Programme in Diabetes at Karolinska Institutet for
   scientific input and help with the metabolism cages. This work was
   supported by grants from the Swedish Research Council (2016-01381 and
   2016-00785), the Swedish Heart and Lung Foundation (20140448 &
   20170124), Novo Nordisk (2019#0055026), and by EFSD/Lilly European
   Diabetes Research Programme (2018#97012), as well as Research Funds
   (2-560/2015) and KID funding (2-3707/2013 & 2-1930/2016) from the
   Karolinska Institutet, Stockholm, Sweden.
CR [Anonymous], FREE RADIC BIOL M S1
   [Anonymous], FREE RADIC BIOL MED
   Carlstrom M, 2019, J INTERN MED, V285, P2, DOI 10.1111/joim.12818
   Carlström M, 2018, ACTA PHYSIOL, V224, DOI 10.1111/apha.13080
   Carlström M, 2010, P NATL ACAD SCI USA, V107, P17716, DOI 10.1073/pnas.1008872107
   Chaudhury A, 2017, FRONT ENDOCRINOL, V8, DOI 10.3389/fendo.2017.00006
   Cordero-Herrera I, 2019, P NATL ACAD SCI USA, V116, P217, DOI 10.1073/pnas.1809406115
   de Mello AH, 2018, LIFE SCI, V192, P26, DOI 10.1016/j.lfs.2017.11.019
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Enerback S, 1997, NATURE, V387, P90, DOI 10.1038/387090a0
   Engin AB, 2017, ADV EXP MED BIOL, V960, P327, DOI 10.1007/978-3-319-48382-5_14
   Fortuño A, 2006, DIABETES, V55, P209, DOI 10.2337/diabetes.55.1.209
   Hezel M, 2016, FREE RADICAL BIO MED, V99, P87, DOI 10.1016/j.freeradbiomed.2016.07.025
   Hezel MP, 2015, REDOX BIOL, V5, P234, DOI 10.1016/j.redox.2015.05.004
   Jädert C, 2012, FREE RADICAL BIO MED, V52, P683, DOI 10.1016/j.freeradbiomed.2011.11.018
   Jastroch M, 2017, P NATL ACAD SCI USA, V114, P7744, DOI 10.1073/pnas.1709064114
   Kazak L, 2019, NAT METAB, V1, P360, DOI 10.1038/s42255-019-0035-x
   Kazak L, 2015, CELL, V163, P643, DOI 10.1016/j.cell.2015.09.035
   Khambata RS, 2017, P NATL ACAD SCI USA, V114, pE550, DOI 10.1073/pnas.1613063114
   Kim JY, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-04175-w
   Larsen FJ, 2012, FREE RADICAL BIO MED, V53, P1919, DOI 10.1016/j.freeradbiomed.2012.08.580
   Larsen FJ, 2011, CELL METAB, V13, P149, DOI 10.1016/j.cmet.2011.01.004
   Li M, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2014-005497
   Bargut TCL, 2017, HORM MOL BIOL CLIN I, V31, DOI 10.1515/hmbci-2016-0051
   Lundberg JO, 2008, NAT REV DRUG DISCOV, V7, DOI [10.1038/nrd2466-c2, 10.1038/nrd2466]
   Lundberg JO, 2018, CELL METAB, V28, P9, DOI 10.1016/j.cmet.2018.06.007
   Matthews VB, 2018, INT J ENDOCRINOL, V2018, DOI 10.1155/2018/7969750
   Nguyen KD, 2011, NATURE, V480, P104, DOI 10.1038/nature10653
   Omar SA, 2016, J INTERN MED, V279, P315, DOI 10.1111/joim.12441
   Peleli M, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00222
   Roberts LD, 2015, DIABETES, V64, P471, DOI 10.2337/db14-0496
   Rocha BS, 2019, NITRIC OXIDE-BIOL CH, V88, P27, DOI 10.1016/j.niox.2019.04.001
   Sadagurski M, 2010, DIABETOLOGIA, V53, P525, DOI 10.1007/s00125-009-1580-8
   Seale P, 2009, GENE DEV, V23, P788, DOI 10.1101/gad.1779209
   Serra D, 2013, ANTIOXID REDOX SIGN, V19, P269, DOI 10.1089/ars.2012.4875
   Stanford KI, 2013, J CLIN INVEST, V123, P215, DOI 10.1172/JCI62308
   Supruniuk E, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00923
   Thomas D, 2017, METABOLISM, V72, P120, DOI 10.1016/j.metabol.2017.04.005
   Tilg H, 2006, NAT REV IMMUNOL, V6, P772, DOI 10.1038/nri1937
   Wallenius V, 2002, NAT MED, V8, P75, DOI 10.1038/nm0102-75
   Wang X, 2014, BMJ-BRIT MED J, V349, DOI 10.1136/bmj.g4490
   Yang T, 2017, REDOX BIOL, V13, P320, DOI 10.1016/j.redox.2017.06.002
   Yang T, 2015, DIABETOLOGIA, V58, P1610, DOI 10.1007/s00125-015-3570-3
   Yang T, 2015, FREE RADICAL BIO MED, V83, P159, DOI 10.1016/j.freeradbiomed.2015.02.016
   Zollbrecht C, 2016, REDOX BIOL, V10, P119, DOI 10.1016/j.redox.2016.09.015
NR 45
TC 35
Z9 38
U1 0
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD JAN
PY 2020
VL 28
AR 101387
DI 10.1016/j.redox.2019.101387
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA JU2FG
UT WOS:000501490700027
PM 31765889
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Goudarzi, R
   Sedaghat, M
   Hedayati, M
   Hekmatdoost, A
   Sohrab, G
AF Goudarzi, Razieh
   Sedaghat, Meghdad
   Hedayati, Mehdi
   Hekmatdoost, Azita
   Sohrab, Golbon
TI Low advanced Glycation end product diet improves the central obesity,
   insulin resistance and inflammatory profiles in Iranian patients with
   metabolic syndrome: a randomized clinical trial
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Article
DE Metabolic syndrome; Obesity; Advanced glycation end products;
   Inflammation; Insulin resistance; Fasting blood glucose
ID DIABETES-MELLITUS; OXIDATIVE STRESS; AGE RESTRICTION; RISK; HEALTHY;
   FOODS; ENDPRODUCTS; GLYCOTOXINS; ACTIVATION
AB The study aimed to investigate the effects of 8-weeks AGEs restricted diet on glycemic control as well as lipid profile, inflammatory and oxidative stress biomarkers and IR in overweight patients with Mets. In this randomized, controlled clinical trial 40 clients were randomly assigned to take either a low AGE (L-AGE) or a regular AGE (Reg-AGE) diet. Also, both groups were advised to follow an energy-restricted diet. At baseline and after 8-weeks of intervention, anthropometric parameters, dietary intake, plasma concentrations of malondialdehyde, carboxymethyllysine, TNF-alpha, hs-CRP and levels of serum glucose, lipid and insulin were assessed. AGEs restriction resulted in significant changes in mean differences levels of CML (p < 0.004), FBG (p < 0.01), HOMA-IR (p < 0.04), TNF-alpha (p < 0.01) and MDA (p < 0.02) in comparison to Reg-AGE. Moreover, weight (p < 0.0001) and WC (p < 0.001) significantly declined in the intervention group. Our results indicate that dAGEs restriction plus a low-calorie diet is superior to a low-calorie diet in amelioration of central obesity and IR at least partially through reduction of OS and inflammation in Mets subjects.
C1 [Goudarzi, Razieh; Hekmatdoost, Azita; Sohrab, Golbon] Shahid Beheshti Univ Med Sci, Dept Clin Nutr & Dietet, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, 46 Hafezi St,Farahzadi Blvd,POB 19395-4741, Tehran, Iran.
   [Sedaghat, Meghdad] Shahid Beheshti Univ Med Sci, Dept Internal Med, Imam Hossein Hosp, Tehran, Iran.
   [Hedayati, Mehdi] Shahid Beheshti Univ Med Sci, Cellular & Mol Endocrine Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Shahid Beheshti University Medical Sciences
RP Sohrab, G (corresponding author), Shahid Beheshti Univ Med Sci, Dept Clin Nutr & Dietet, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, 46 Hafezi St,Farahzadi Blvd,POB 19395-4741, Tehran, Iran.
EM golbonsohrab@yahoo.com
RI Sohrab, Golbon/AHE-4922-2022; Hedayati, Mehdi/AAG-3006-2019;
   Hekmatdoost, Azita/AGM-6497-2022; goudarzi, razieh/J-1328-2017
OI Hekmatdoost, Azita/0000-0002-1944-0052; goudarzi,
   razieh/0000-0003-1091-7552
CR Ahima R. S, 2016, METABOLIC SYNDROME C, P3, DOI DOI 10.1007/978-3-319-11251-0_1
   Ahluwalia N, 2013, DIABETES METAB, V39, P99, DOI 10.1016/j.diabet.2012.08.007
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Angoorani P, 2016, INT J FOOD SCI NUTR, V67, P170, DOI 10.3109/09637486.2015.1137889
   Baye E, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-04214-6
   Birlouez-Aragon I, 2010, AM J CLIN NUTR, V91, P1220, DOI 10.3945/ajcn.2009.28737
   Cai WJ, 2006, P NATL ACAD SCI USA, V103, P13801, DOI 10.1073/pnas.0600362103
   Cai WJ, 2014, P NATL ACAD SCI USA, V111, P4940, DOI 10.1073/pnas.1316013111
   Chao PC, 2009, FOOD CHEM, V113, P262, DOI 10.1016/j.foodchem.2008.06.076
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   Clarke RE, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030125
   Di Pino A, 2016, J CLIN LIPIDOL, V10, P1098, DOI 10.1016/j.jacl.2016.07.001
   Ghaffarpour M, 1999, Tehran Nashre Olume Keshavarzy, V7, P42
   Macías-Cervantes MH, 2015, NUTRITION, V31, P446, DOI 10.1016/j.nut.2014.10.004
   Hull GLJ, 2012, FOOD CHEM, V131, P170, DOI 10.1016/j.foodchem.2011.08.055
   Kelli HM, 2015, J DIABETES METAB, V6, DOI 10.4172/2155-6156.1000513
   Kellow NJ, 2013, EUR J CLIN NUTR, V67, P239, DOI 10.1038/ejcn.2012.220
   Lam DWLD, 2015, ENDOTEXT
   Luévano-Contreras C, 2013, J CLIN BIOCHEM NUTR, V52, P22, DOI 10.3164/jcbn.12-40
   Lutsey PL, 2008, CIRCULATION, V117, P754, DOI 10.1161/CIRCULATIONAHA.107.716159
   Mark AB, 2014, DIABETES CARE, V37, P88, DOI 10.2337/dc13-0842
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Poulsen MW, 2014, EUR J NUTR, V53, P661, DOI 10.1007/s00394-013-0574-y
   Rodríguez-Monforte M, 2017, EUR J NUTR, V56, P925, DOI 10.1007/s00394-016-1305-y
   Scheijen JLJM, 2016, FOOD CHEM, V190, P1145, DOI 10.1016/j.foodchem.2015.06.049
   Semba RD, 2014, J NUTR, V144, P1037, DOI 10.3945/jn.113.189480
   Uribarri J, 2015, J CLIN ENDOCR METAB, V100, P1957, DOI 10.1210/jc.2014-3925
   Uribarri J, 2014, AMINO ACIDS, V46, P301, DOI 10.1007/s00726-013-1502-4
   Uribarri J, 2011, DIABETES CARE, V34, P1610, DOI 10.2337/dc11-0091
   Uribarri J, 2010, J AM DIET ASSOC, V110, P911, DOI 10.1016/j.jada.2010.03.018
   Van Puyvelde K, 2014, NUTR REV, V72, P638, DOI 10.1111/nure.12141
   Vlassara H, 2002, P NATL ACAD SCI USA, V99, P15596, DOI 10.1073/pnas.242407999
   Vlassara H, 2016, DIABETOLOGIA, V59, P2181, DOI 10.1007/s00125-016-4053-x
   Vlassara H, 2014, CURR DIABETES REP, V14, DOI 10.1007/s11892-013-0453-1
   Vlassara H, 2011, NAT REV ENDOCRINOL, V7, P526, DOI 10.1038/nrendo.2011.74
   Vlassara H, 2009, J CLIN ENDOCR METAB, V94, P4483, DOI 10.1210/jc.2009-0089
   Yacoub R, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184789
NR 38
TC 16
Z9 16
U1 0
U2 7
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD DEC
PY 2020
VL 19
IS 2
BP 1129
EP 1138
DI 10.1007/s40200-020-00614-0
EA AUG 2020
PG 10
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA QC8UX
UT WOS:000567565000001
PM 33520830
OA Green Published
DA 2025-06-11
ER

PT J
AU Whaley-Connell, A
   McCullough, PA
   Sowers, JR
AF Whaley-Connell, Adam
   McCullough, Peter A.
   Sowers, James R.
TI The Role of Oxidative Stress in the Metabolic Syndrome
SO REVIEWS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE Metabolic syndrome; Oxidative stress; Labile iron; Neutrophil-associated
   lipocalin; Galectin-3
ID ANGIOTENSIN-ALDOSTERONE SYSTEM; CORONARY-HEART-DISEASE; NITRIC-OXIDE
   SYNTHASE; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; NAD(P)H OXIDASE;
   CLINICAL-IMPLICATIONS; INDUCED HYPERTENSION; KIDNEY-DISEASE; NADPH
   OXIDASES
AB Loss of reduction-oxidation (redox) homeostasis and generation of excess free oxygen radicals play an important role in the pathogenesis of diabetes, hypertension, and consequent cardiovascular disease. Reactive oxygen species are integral in routine in physiologic mechanisms. However, loss of redox homeostasis contributes to proinflammatory and pro fibrotic pathways that promote impairments in insulin metabolic signaling, reduced endothelial-mediated vasorelaxation, and associated cardiovascular and renal structural and functional abnormalities. Redox control of metabolic function is a dynamic process with reversible pro- and anti-free radical processes. Labile iron is necessary for the catalysis of superoxide anion, hydrogen peroxide, and the generation of the damaging hydroxyl radical. Acute hypoxia and cellular damage in cardiovascular tissue liberate larger amounts of cytosolic and extracellular iron that is poorly liganded; thus, large increases in the generation of oxygen free radicals are possible, causing tissue damage. The understanding of iron and the imbalance of redox homeostasis within the vasculature is integral in hypertension and progression of metabolic dysregulation that contributes to insulin resistance, endothelial dysfunction, and cardiovascular and kidney disease. [Rev Cardiovasc Med. 2011;12(1):21-29 doi: 10.3909/ricm0555] (C) 2011 MedReviews (R), LLC
C1 [Whaley-Connell, Adam; Sowers, James R.] Harry S Truman VA Med Ctr, Diabet & Cardiovasc Ctr, Columbia, MO 65201 USA.
   [Whaley-Connell, Adam; Sowers, James R.] Univ Missouri, Sch Med, Columbia, MO USA.
   [McCullough, Peter A.] Providence Pk Hosp, St John Providence Hlth Syst, Dept Med, Cardiol Sect, Novi, MI USA.
C3 University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; University of Missouri
   System; University of Missouri Columbia; St. John Hospital & Medical
   Center
RP Whaley-Connell, A (corresponding author), Harry S Truman VA Med Ctr, Diabet & Cardiovasc Ctr, Columbia, MO 65201 USA.
OI Whaley-Connell, Adam/0000-0001-8955-5560
CR Amer Diabet Assoc, 2008, DIABETES CARE, V31, pS12, DOI 10.2337/dc08-S012
   Arts ICW, 2005, AM J CLIN NUTR, V81, p317S, DOI 10.1093/ajcn/81.1.317S
   Bedard K, 2007, PHYSIOL REV, V87, P245, DOI 10.1152/physrev.00044.2005
   Bolignano D, 2010, EUR J CLIN INVEST, V40, P273, DOI 10.1111/j.1365-2362.2010.02258.x
   Bolignano D, 2008, AM J KIDNEY DIS, V52, P595, DOI 10.1053/j.ajkd.2008.01.020
   Bomback AS, 2009, AM J NEPHROL, V30, P140, DOI 10.1159/000209744
   Bosch J, 2006, NEW ENGL J MED, V355, P1551
   Bravo L, 1998, NUTR REV, V56, P317, DOI 10.1111/j.1753-4887.1998.tb01670.x
   Brown NJ, 2008, HYPERTENSION, V51, P161, DOI 10.1161/HYPERTENSIONAHA.107.095489
   Campese VM, 2005, J AM SOC NEPHROL, V16, pS11, DOI 10.1681/ASN.2004110958
   Cohn JN, 2007, ADV THER, V24, P1290, DOI 10.1007/BF02877776
   Cook NC, 1996, J NUTR BIOCHEM, V7, P66, DOI 10.1016/0955-2863(95)00168-9
   Cooper R, 1998, J HYPERTENS, V16, P571, DOI 10.1097/00004872-199816050-00003
   Cooper R, 1997, J HUM HYPERTENS, V11, P107, DOI 10.1038/sj.jhh.1000391
   Cooper SA, 2007, AM J PHYSIOL-HEART C, V293, pH2009, DOI 10.1152/ajpheart.00522.2007
   Cosentino F, 1997, CIRCULATION, V96, P25
   de Boer RA, 2009, EUR J HEART FAIL, V11, P811, DOI 10.1093/eurjhf/hfp097
   De Vries B, 2004, TRANSPLANTATION, V77, P669, DOI 10.1097/01.TP.0000115002.28575.E7
   DEFRONZO RA, 1975, J CLIN INVEST, V55, P845, DOI 10.1172/JCI107996
   Dombrecht EJ, 2006, BIOCHEM BIOPH RES CO, V348, P459, DOI 10.1016/j.bbrc.2006.07.075
   Duffy SJ, 2001, CIRCULATION, V103, P2799
   DUSI S, 1995, BIOCHEM J, V308, P991, DOI 10.1042/bj3080991
   Engeli S, 2001, J MOL MED, V79, P21, DOI 10.1007/s001090000144
   Engeli S, 2000, HYPERTENSION, V35, P1270, DOI 10.1161/01.HYP.35.6.1270
   England K, 2006, FREE RADICAL RES, V40, P1124, DOI 10.1080/10715760600838209
   Flegal KM, 1998, INT J OBESITY, V22, P39, DOI 10.1038/sj.ijo.0800541
   Fleming I, 1998, CIRC RES, V82, P686, DOI 10.1161/01.RES.82.6.686
   Fraga CG, 2002, TOXICOLOGY, V180, P23, DOI 10.1016/S0300-483X(02)00379-7
   Goodfriend TL, 1998, ENDOCR RES, V24, P789, DOI 10.3109/07435809809032689
   Goodfriend TL, 1999, PROSTAG LEUKOTR ESS, V60, P401, DOI 10.1016/S0952-3278(99)80020-9
   GRANGER JP, 1994, HYPERTENSION, V23, pI8, DOI 10.1161/01.HYP.23.1_Suppl.I8
   Griendling KK, 2000, CIRC RES, V86, P494, DOI 10.1161/01.RES.86.5.494
   Habibi J, 2008, ENDOCRINOLOGY, V149, P5643, DOI 10.1210/en.2008-0070
   Habibi J, 2007, ENDOCRINOLOGY, V148, P2181, DOI 10.1210/en.2006-1355
   HALL JE, 1993, HYPERTENSION, V22, P292, DOI 10.1161/01.HYP.22.3.292
   Heitzer T, 2000, CIRC RES, V86, pE36, DOI 10.1161/01.RES.86.2.e36
   Hirono Y, 2007, ENDOCRINOLOGY, V148, P1688, DOI 10.1210/en.2006-1157
   Horwitz LD, 1998, P NATL ACAD SCI USA, V95, P5263, DOI 10.1073/pnas.95.9.5263
   Hovorka SW, 2001, J PHARM SCI-US, V90, P253, DOI 10.1002/1520-6017(200103)90:3<253::AID-JPS1>3.0.CO;2-W
   Isomaa B, 2003, LIFE SCI, V73, P2395, DOI 10.1016/S0024-3205(03)00646-5
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Kell DB, 2009, BMC MED GENOMICS, V2, DOI 10.1186/1755-8794-2-2
   Krauss RM, 2000, CIRCULATION, V102, P2284
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lambeth JD, 2007, FREE RADICAL BIO MED, V43, P332, DOI 10.1016/j.freeradbiomed.2007.03.027
   Lassègue B, 2003, AM J PHYSIOL-REG I, V285, pR277, DOI 10.1152/ajpregu.00758.2002
   Lastra G, 2009, ENDOCRINOLOGY, V150, P2561, DOI 10.1210/en.2008-1391
   Li JM, 2002, CIRC RES, V90, P143, DOI 10.1161/hh0202.103615
   LICATA G, 1994, HYPERTENSION, V23, pI20, DOI 10.1161/01.HYP.23.1_Suppl.I20
   Lotito SB, 2006, FREE RADICAL BIO MED, V41, P1727, DOI 10.1016/j.freeradbiomed.2006.04.033
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   MASON PR, 2011, CIRCULATION, V109, P34
   McFarlane SI, 2001, J CLIN ENDOCR METAB, V86, P713, DOI 10.1210/jc.86.2.713
   McMurray JJ, 2010, NEW ENGL J MED, V362, P1477, DOI 10.1056/NEJMoa1001121
   Mollnau H, 2002, CIRC RES, V90, pE58, DOI 10.1161/01.RES.0000012569.55432.02
   Ness AR, 1997, INT J EPIDEMIOL, V26, P1, DOI 10.1093/ije/26.1.1
   Nijveldt RJ, 2001, AM J CLIN NUTR, V74, P418
   Paravicini TM, 2008, DIABETES CARE, V31, pS170, DOI 10.2337/dc08-s247
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Reaven GM, 2004, DIABETES CARE, V27, P1011, DOI 10.2337/diacare.27.4.1011
   Reaven GM, 1996, CIRCULATION, V93, P1780, DOI 10.1161/01.CIR.93.10.1780
   REISIN E, 1987, J HYPERTENS, V5, P397
   Rey FE, 2001, CIRC RES, V89, P408, DOI 10.1161/hh1701.096037
   ROCCHINI AP, 1990, HYPERTENSION, V15, P861, DOI 10.1161/01.HYP.15.6.861
   Rocchini AP, 1997, AM J PHYSIOL-ENDOC M, V272, pE147, DOI 10.1152/ajpendo.1997.272.1.E147
   Schiffrin EL, 2006, HYPERTENSION, V47, P312, DOI 10.1161/01.HYP.0000201443.63240.a7
   Schorr U, 1998, J HYPERTENS, V16, P1475, DOI 10.1097/00004872-199816100-00011
   SHAHIDI F, 1992, CRIT REV FOOD SCI, V32, P67, DOI 10.1080/10408399209527581
   Sowers JR, 2009, ANN INTERN MED, V150, P776, DOI 10.7326/0003-4819-150-11-200906020-00005
   Sowers JR, 2003, AM J MED, V115, P37, DOI 10.1016/j.amjmed.2003.08.012
   Stas S, 2007, ENDOCRINOLOGY, V148, P3773, DOI 10.1210/en.2006-1691
   Van Gaal LF, 2006, NATURE, V444, P875, DOI 10.1038/nature05487
   Wei YZ, 2008, AM J PHYSIOL-REG I, V294, pR673, DOI 10.1152/ajpregu.00561.2007
   Wei YZ, 2009, HYPERTENSION, V53, P158, DOI 10.1161/HYPERTENSIONAHA.108.121954
   Whaley-Connell A, 2010, J CLIN HYPERTENS, V12, P51, DOI 10.1111/j.1751-7176.2009.00190.x
   Whaley-Connell AT, 2007, AM J NEPHROL, V27, P15, DOI 10.1159/000098432
   Williams JS, 2003, J CLIN ENDOCR METAB, V88, P2364, DOI 10.1210/jc.2003-030490
   Wolfrum S, 2003, ARTERIOSCL THROM VAS, V23, P729, DOI 10.1161/01.ATV.0000063385.12476.A7
   Wright JS, 2001, J AM CHEM SOC, V123, P1173, DOI 10.1021/ja002455u
   Yang CS, 2001, ANNU REV NUTR, V21, P381, DOI 10.1146/annurev.nutr.21.1.381
   Zhang H, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004129
NR 81
TC 99
Z9 115
U1 0
U2 11
PU IMR PRESS
PI WAN CHAI
PA RM 19C, LOCKHART CTR, 301-307 LOCKHART RD, WAN CHAI, 00000, HONG KONG
SN 1530-6550
EI 2153-8174
J9 REV CARDIOVASC MED
JI Rev. Cardiovasc. Med.
PY 2011
VL 12
IS 1
BP 21
EP 29
DI 10.3909/ricm0555
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 746SM
UT WOS:000289267500003
PM 21546885
OA Bronze
DA 2025-06-11
ER

PT J
AU Nunn, AV
   Guy, GW
   Brodie, JS
   Bell, JD
AF Nunn, Alistair V.
   Guy, Geoffrey W.
   Brodie, James S.
   Bell, Jimmy D.
TI Inflammatory modulation of exercise salience: using hormesis to return
   to a healthy lifestyle
SO NUTRITION & METABOLISM
LA English
DT Article
ID SPONTANEOUS PHYSICAL-ACTIVITY; DIET-INDUCED OBESITY; C-REACTIVE PROTEIN;
   METABOLIC SYNDROME; ADIPOSE-TISSUE; VISCERAL FAT; MITOCHONDRIAL
   BIOGENESIS; CALORIE RESTRICTION; VOLUNTARY EXERCISE; SICKNESS BEHAVIOR
AB Most of the human population in the western world has access to unlimited calories and leads an increasingly sedentary lifestyle. The propensity to undertake voluntary exercise or indulge in spontaneous physical exercise, which might be termed "exercise salience", is drawing increased scientific attention. Despite its genetic aspects, this complex behaviour is clearly modulated by the environment and influenced by physiological states. Inflammation is often overlooked as one of these conditions even though it is known to induce a state of reduced mobility. Chronic subclinical inflammation is associated with the metabolic syndrome; a largely lifestyle-induced disease which can lead to decreased exercise salience. The result is a vicious cycle that increases oxidative stress and reduces metabolic flexibility and perpetuates the disease state. In contrast, hormetic stimuli can induce an anti-inflammatory phenotype, thereby enhancing exercise salience, leading to greater biological fitness and improved functional longevity. One general consequence of hormesis is upregulation of mitochondrial function and resistance to oxidative stress. Examples of hormetic factors include calorie restriction, extreme environmental temperatures, physical activity and polyphenols. The hormetic modulation of inflammation, and thus, exercise salience, may help to explain the highly heterogeneous expression of voluntary exercise behaviour and therefore body composition phenotypes of humans living in similar obesogenic environments.
C1 [Nunn, Alistair V.; Bell, Jimmy D.] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, MRC Clin Sci Ctr, Metab & Mol Imaging Grp, London W12 OHS, England.
   [Guy, Geoffrey W.; Brodie, James S.] GW Pharmaceut, Salisbury SP4 0JQ, Wilts, England.
C3 Imperial College London
RP Nunn, AV (corresponding author), Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, MRC Clin Sci Ctr, Metab & Mol Imaging Grp, Du Cane Rd, London W12 OHS, England.
EM alistair.nunn@btconnect.com
RI Nunn, Alistair/ABE-2462-2020
OI Bell, Jimmy/0000-0003-3804-1281
FU GW pharmaceuticals; MRC [MC_U120061305] Funding Source: UKRI
FX To GW pharmaceuticals for financial support that enabled the development
   of the original hypothesis and the writing of the manuscript. We would
   also like to thank Andrea Nunn for help in clarifying the central ideas
   through informal discussion and Marcos Esteban Qui ones Lembach por
   inspiratio.
CR Abraham J, 2009, REJUV RES, V12, P445, DOI 10.1089/rej.2009.0888
   [Anonymous], 2010, International Journal of Diabetes Mellitus, DOI DOI 10.1016/J.IJDM.2009.12.009
   Bilal E, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002421
   Biro PA, 2010, TRENDS ECOL EVOL, V25, P653, DOI 10.1016/j.tree.2010.08.003
   Bjursell M, 2008, AM J PHYSIOL-ENDOC M, V294, pE251, DOI 10.1152/ajpendo.00401.2007
   Brené S, 2007, PHYSIOL BEHAV, V92, P136, DOI 10.1016/j.physbeh.2007.05.015
   Brookes PS, 2004, AM J PHYSIOL-CELL PH, V287, pC817, DOI 10.1152/ajpcell.00139.2004
   Calabrese V, 2010, ANTIOXID REDOX SIGN, V13, P1763, DOI 10.1089/ars.2009.3074
   Caldwell SH, 2007, J GASTROEN HEPATOL, V22, pS11, DOI 10.1111/j.1440-1746.2006.04639.x
   Call JA, 2008, J APPL PHYSIOL, V105, P923, DOI 10.1152/japplphysiol.00028.2008
   Cinti S, 2005, J LIPID RES, V46, P2347, DOI 10.1194/jlr.M500294-JLR200
   Civitarese AE, 2007, PLOS MED, V4, P485, DOI 10.1371/journal.pmed.0040076
   Csiszar A, 2009, AM J PHYSIOL-HEART C, V297, pH13, DOI 10.1152/ajpheart.00368.2009
   Dantzer R, 2001, ANN NY ACAD SCI, V933, P222
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   Davis JM, 2010, INT J SPORT NUTR EXE, V20, P56, DOI 10.1123/ijsnem.20.1.56
   Davis JM, 2009, AM J PHYSIOL-REG I, V296, pR1071, DOI 10.1152/ajpregu.90925.2008
   Devaraj S, 2008, AM J CLIN PATHOL, V129, P815, DOI 10.1309/RN84K51B2JJY1Y0B
   Eiholzer U, 2010, J PEDIATR-US, V156, P242, DOI 10.1016/j.jpeds.2009.08.039
   Finocchietto PV, 2009, EXP BIOL MED, V234, P1020, DOI 10.3181/0902-MR-81
   Fiorani M, 2010, J NUTR BIOCHEM, V21, P397, DOI 10.1016/j.jnutbio.2009.01.014
   Frassetto LA, 2009, EUR J CLIN NUTR, V63, P947, DOI 10.1038/ejcn.2009.4
   Freedland Eric S, 2004, Nutr Metab (Lond), V1, P12, DOI 10.1186/1743-7075-1-12
   Fridlyand LE, 2006, MED HYPOTHESES, V67, P1034, DOI 10.1016/j.mehy.2006.04.057
   Fuku N, 2007, AM J HUM GENET, V80, P407, DOI 10.1086/512202
   Guarente L, 2008, CELL, V132, P171, DOI 10.1016/j.cell.2008.01.007
   Guisinger S, 2003, PSYCHOL REV, V110, P745, DOI 10.1037/0033-295X.110.4.745
   Gustafson B, 2009, AM J PHYSIOL-ENDOC M, V297, pE999, DOI 10.1152/ajpendo.00377.2009
   Guy Geoffrey W., 2009, International Journal of Diabetes Mellitus, V1, P43
   Harman-Boehm I, 2007, J CLIN ENDOCR METAB, V92, P2240, DOI 10.1210/jc.2006-1811
   Hoenig MR, 2010, NUTR METAB, V7, DOI 10.1186/1743-7075-7-50
   Hong JK, 2008, J EXP BOT, V59, P147, DOI 10.1093/jxb/erm244
   Hong X, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-148
   Hooper PL, 2010, CELL STRESS CHAPERON, V15, P761, DOI 10.1007/s12192-010-0206-x
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Huang P, 2010, NUTR METAB, V7, DOI 10.1186/1743-7075-7-59
   JAMES WPT, 1982, HUM NUTR-CLIN NUTR, V36, P331
   Jeong SK, 2008, J KOREAN MED SCI, V23, P789, DOI 10.3346/jkms.2008.23.5.789
   Jerstad SJ, 2010, J CONSULT CLIN PSYCH, V78, P268, DOI 10.1037/a0018793
   Ji LL, 2010, DOSE-RESPONSE, V8, P73, DOI 10.2203/dose-response.09-048.Ji
   Johannsen DL, 2008, CURR OPIN ENDOCRINOL, V15, P409, DOI 10.1097/MED.0b013e32830b10bb
   Kahn A, 2010, DOSE-RESPONSE, V8, P48, DOI 10.2203/dose-response.09-031.Olsen
   Katzmarzyk PT, 2005, DIABETES CARE, V28, P391, DOI 10.2337/diacare.28.2.391
   Kelly SA, 2010, PHYSIOL GENOMICS, V42, P190, DOI 10.1152/physiolgenomics.00028.2010
   Kirkwood TBL, 2008, J INTERN MED, V263, P117, DOI 10.1111/j.1365-2796.2007.01901.x
   Klempel MC, 2010, NUTR J, V9, DOI 10.1186/1475-2891-9-35
   Kotchoni SO, 2006, J BIOSCIENCES, V31, P389, DOI 10.1007/BF02704112
   Lagouge M, 2006, CELL, V127, P1109, DOI 10.1016/j.cell.2006.11.013
   Lamming DW, 2004, MOL MICROBIOL, V53, P1003, DOI 10.1111/j.1365-2958.2004.04209.x
   Lane N, 2010, NATURE, V467, P929, DOI 10.1038/nature09486
   Lee S, 2005, DIABETES CARE, V28, P895, DOI 10.2337/diacare.28.4.895
   Marques FZ, 2010, DOSE-RESPONSE, V8, P28, DOI 10.2203/dose-response.09-021.Morris
   McIntyre Roger S, 2007, Ann Clin Psychiatry, V19, P257, DOI 10.1080/10401230701653377
   McMurray Robert G, 2008, Dyn Med, V7, P5, DOI 10.1186/1476-5918-7-5
   Meek TH, 2010, INT J OBESITY, V34, P960, DOI 10.1038/ijo.2010.25
   Miller AH, 2009, BIOL PSYCHIAT, V65, P732, DOI 10.1016/j.biopsych.2008.11.029
   Montero M, 2004, BIOCHEM J, V384, P19, DOI 10.1042/BJ20040990
   Murase T, 2006, AM J PHYSIOL-REG I, V290, pR1550, DOI 10.1152/ajpregu.00752.2005
   Muzumdar R, 2008, AGING CELL, V7, P438, DOI 10.1111/j.1474-9726.2008.00391.x
   Nadjar A, 2005, NEUROPSYCHOPHARMACOL, V30, P1492, DOI 10.1038/sj.npp.1300755
   Nehrenberg DL, 2009, OBESITY, V17, P1402, DOI 10.1038/oby.2009.51
   Norman C, 2004, PLANT PHYSIOL, V134, P492, DOI 10.1104/pp.103.031039
   Nunn AVW, 2009, NUTR METAB, V6, DOI 10.1186/1743-7075-6-16
   Olholm J, 2010, INT J OBESITY, V34, P1546, DOI 10.1038/ijo.2010.98
   Parashar V, 2009, AGING-US, V1, P529, DOI 10.18632/aging.100061
   Pardon MC, 2010, DOSE-RESPONSE, V8, P22, DOI 10.2203/dose-response.09-020.Pardon
   Parsons PA, 2007, BIOGERONTOLOGY, V8, P613, DOI 10.1007/s10522-007-9101-y
   Pasco JA, 2010, BRIT J PSYCHIAT, V197, P372, DOI 10.1192/bjp.bp.109.076430
   Petersen AMW, 2005, J APPL PHYSIOL, V98, P1154, DOI 10.1152/japplphysiol.00164.2004
   PIRKE KM, 1993, NEUROSCI BIOBEHAV R, V17, P287, DOI 10.1016/S0149-7634(05)80012-0
   Puigserver P, 2003, ENDOCR REV, V24, P78, DOI 10.1210/er.2002-0012
   Ramsey JJ, 1997, AM J PHYSIOL-ENDOC M, V272, pE901, DOI 10.1152/ajpendo.1997.272.5.E901
   Rankinen T, 2010, MED SCI SPORT EXER, V42, P835, DOI 10.1249/MSS.0b013e3181d86cec
   Rattan SIS, 2004, ANN NY ACAD SCI, V1019, P554, DOI 10.1196/annals.1297.103
   Rattan SIS, 2010, DOSE-RESPONSE, V8, P58, DOI 10.2203/dose-response.09-041.Rattan
   Redman LM, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004377
   REDMAN LM, 2010, ANTIOXID REDOX SIGNA
   Roldán A, 2003, J AGR FOOD CHEM, V51, P1464, DOI 10.1021/jf020774u
   Rottenberg H, 2007, EXP GERONTOL, V42, P364, DOI 10.1016/j.exger.2006.10.016
   Rowland TW, 1998, MED SCI SPORT EXER, V30, P392, DOI 10.1097/00005768-199803000-00009
   Sano M, 2008, CIRC RES, V103, P1191, DOI 10.1161/CIRCRESAHA.108.189092
   Schroeder EK, 2009, ANTIOXID REDOX SIGN, V11, P469, DOI [10.1089/ars.2008.2215, 10.1089/ARS.2008.2215]
   Sene-Fiorese M, 2008, OBESITY, V16, P2217, DOI 10.1038/oby.2008.339
   Serafim TL, 2008, CANCER CHEMOTH PHARM, V61, P1007, DOI 10.1007/s00280-007-0558-9
   Snitker S, 2001, INT J OBESITY, V25, P1481, DOI 10.1038/sj.ijo.0801746
   Son TG, 2008, NEUROMOL MED, V10, P236, DOI 10.1007/s12017-008-8037-y
   Strissel KJ, 2007, DIABETES, V56, P2910, DOI 10.2337/db07-0767
   Tapia PC, 2006, MED HYPOTHESES, V66, P832, DOI 10.1016/j.mehy.2005.09.009
   Thomas EL, 2000, LIPIDS, V35, P769, DOI 10.1007/s11745-000-0584-0
   Treutter D, 2005, PLANT BIOLOGY, V7, P581, DOI 10.1055/s-2005-873009
   van der Poorten D, 2008, HEPATOLOGY, V48, P449, DOI 10.1002/hep.22350
   Varady KA, 2007, AM J CLIN NUTR, V86, P7, DOI 10.1093/ajcn/86.1.7
   Wallace DC, 2008, GENETICS, V179, P727, DOI 10.1534/genetics.104.91769
   Wallace DC, 2010, ANNU REV PATHOL-MECH, V5, P297, DOI 10.1146/annurev.pathol.4.110807.092314
   Weber JM, 2009, J EXP BIOL, V212, P593, DOI 10.1242/jeb.015024
   Weed JL, 1997, PHYSIOL BEHAV, V62, P97, DOI 10.1016/S0031-9384(97)00147-9
   Wersching H, 2010, NEUROLOGY, V74, P1022, DOI 10.1212/WNL.0b013e3181d7b45b
   Yao N, 2004, PLANT J, V40, P596, DOI 10.1111/j.1365-313X.2004.02239.x
NR 98
TC 27
Z9 28
U1 0
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD DEC 9
PY 2010
VL 7
AR 87
DI 10.1186/1743-7075-7-87
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 698UV
UT WOS:000285619600001
PM 21143891
OA gold, Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Camps, J
   Marsillach, J
   Joven, J
AF Camps, Jordi
   Marsillach, Judit
   Joven, Jorge
TI The paraoxonases: role in human diseases and methodological difficulties
   in measurement
SO CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
LA English
DT Review
DE Apolipoproteins; arteriosclerosis; diabetes; high density lipoprotein;
   lactonase; lipid peroxidation; lipoproteins; liver disease; metabolic
   syndrome; method evaluation; oxidative stress; paraoxonase-1;
   paraoxonase-2; paraoxonase-3
ID HIGH-DENSITY-LIPOPROTEIN; HUMAN-SERUM PARAOXONASE; APOLIPOPROTEIN-A-I;
   CORONARY-HEART-DISEASE; ADENOVIRUS-MEDIATED EXPRESSION; REVERSE
   CHOLESTEROL TRANSPORT; PLATELET-ACTIVATING-FACTOR; ONSET
   ALZHEIMERS-DISEASE; PON1 GENE POLYMORPHISMS; OXIDATIVE STRESS
AB Research into the paraoxonase (PON) gene family has flourished over the past few years. In the 1970s and 1980s, only PON1 was known, and the investigations were conducted, essentially, by toxicologists focusing on protection against organophosphate poisoning. Since then, two new members of the family, PON2 and PON3, have been identified, both being shown to play antioxidant and anti-inflammatory roles. Evidence exists indicating that the PON family is central to a wide variety of human illnesses such as cardiovascular disease, diabetes mellitus, metabolic syndrome, obesity, non-alcoholic steatohepatitis, and several mental disorders. However, research is hampered considerably by the methods currently available to measure the activity of these enzymes. In this review, we summarize the state of knowledge on PON biochemistry and function, the influence of genetic variations, and the involvement of PON in several diseases. The problems associated with PON measurement, such as sample acquisition, lack of reference methods, and variety of substrates, will be presented. Also, we cover some of the present lines of research and propose some others for future progress in this field.
C1 [Camps, Jordi; Marsillach, Judit; Joven, Jorge] Univ Rovira & Virgili, Hosp Univ St Joan, Ctr Rec Biomed, Inst Invest Sanitaria Pere Virgili, Reus 43201, Spain.
C3 Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV)
RP Camps, J (corresponding author), Univ Rovira & Virgili, Hosp Univ St Joan, Ctr Rec Biomed, Inst Invest Sanitaria Pere Virgili, C St Joan S-N, Reus 43201, Spain.
EM jcamps@grupsagessa.cat
RI Camps, Jordi/AAG-3080-2020; Marsillach, Judit/I-1329-2015; Joven,
   Jorge/B-3360-2016
OI Joven, Jorge/0000-0003-2749-4541
FU Instituto de Salud Carlos III [FIS 02/0430, 04/1752, 05/1607, RCMN
   C03/08, RD06]; Ministerio de Sanidad, Madrid, Spain; Generalitat de
   Catalunya [FI 05/00068]
FX The authors of this manuscript belong to the Working Group on Markers of
   Oxidative Stress and Inflammation of the Spanish Society of Clinical
   Chemistry and Molecular Pathology. Some studies described in this
   article have been funded by grants from the Instituto de Salud Carlos
   III (FIS 02/0430, 04/1752, 05/1607, RCMN C03/08, and RD06), Ministerio
   de Sanidad, Madrid, Spain. J. M. is the recipient of a post-graduate
   fellowship from the Generalitat de Catalunya (FI 05/00068).
CR ADKINS S, 1993, AM J HUM GENET, V52, P598
   Aharoni A, 2005, NAT GENET, V37, P73, DOI 10.1038/ng1482
   Aharoni A, 2005, CHEM BIOL, V12, P1281, DOI 10.1016/j.chembiol.2005.09.012
   Aharoni A, 2004, P NATL ACAD SCI USA, V101, P482, DOI 10.1073/pnas.2536901100
   Ahmed Z, 2001, J BIOL CHEM, V276, P24473, DOI 10.1074/jbc.M010459200
   Akhmedova SN, 2001, J NEUROL SCI, V184, P179, DOI 10.1016/S0022-510X(01)00439-7
   ALDRIDGE WN, 1953, BIOCHEM J, V53, P110, DOI 10.1042/bj0530110
   ALDRIDGE WN, 1953, BIOCHEM J, V53, P117, DOI 10.1042/bj0530117
   ALDRIDGE WN, 1989, ENZYMES HYDROLYSING ORGANOPHOSPHORUS COMPOUNDS, P1
   Alonsa-Villaverde C, 2003, AIDS, V17, P1173, DOI [10.1097/00002030-200305230-00009, 10.1097/01.aids.0000060360.78202.05]
   Alonso-Villaverde C, 2005, AIDS, V19, P341
   Alves JD, 2003, IMMUNOBIOLOGY, V207, P23, DOI 10.1078/0171-2985-00215
   Anantharamaiah GM, 2007, J LIPID RES, V48, P1915, DOI 10.1194/jlr.R700010-JLR200
   [Anonymous], ARTERIOSCLER THROMB
   Ansell BJ, 2005, J AM COLL CARDIOL, V46, P1792, DOI 10.1016/j.jacc.2005.06.080
   Aslan M, 2008, ATHEROSCLEROSIS, V196, P270, DOI 10.1016/j.atherosclerosis.2006.10.024
   Aviram M, 2000, CIRCULATION, V101, P2510, DOI 10.1161/01.CIR.101.21.2510
   Aviram M, 2004, FREE RADICAL BIO MED, V37, P1304, DOI 10.1016/j.freeradbiomed.2004.06.030
   Aviram M, 2004, FREE RADICAL BIO MED, V37, P1301, DOI 10.1016/j.freeradbiomed.2004.07.009
   Aviram M, 1998, ARTERIOSCL THROM VAS, V18, P1617, DOI 10.1161/01.ATV.18.10.1617
   Aviram M, 1999, FREE RADICAL BIO MED, V26, P892, DOI 10.1016/S0891-5849(98)00272-X
   Aviram M, 1998, J CLIN INVEST, V101, P1581, DOI 10.1172/JCI1649
   Ayub A, 1999, ARTERIOSCL THROM VAS, V19, P330, DOI 10.1161/01.ATV.19.2.330
   Benmoyal-Segal L, 2005, FASEB J, V19, P452, DOI 10.1096/fj.04-2106fje
   Bergmeier C, 2004, CLIN CHEM, V50, P2309, DOI 10.1373/clinchem.2004.034439
   Bershtein S, 2008, CURR OPIN CHEM BIOL, V12, P151, DOI 10.1016/j.cbpa.2008.01.027
   BHATTACHARYYA T, 2008, JAMA-J AM MED ASSOC, V300, P168
   Biggadike K, 2000, J MED CHEM, V43, P19, DOI 10.1021/jm990436t
   Billeclke S, 2000, DRUG METAB DISPOS, V28, P1335
   Bin Ali A, 2003, FREE RADICAL BIO MED, V34, P824, DOI 10.1016/S0891-5849(02)01436-3
   Birjmohun RS, 2007, ARTERIOSCL THROM VAS, V27, P1153, DOI 10.1161/ATVBAHA.106.136325
   BLATTER MC, 1993, EUR J BIOCHEM, V211, P871, DOI 10.1111/j.1432-1033.1993.tb17620.x
   Bloedon LT, 2008, J LIPID RES, V49, P1344, DOI 10.1194/jlr.P800003-JLR200
   Boehm D, 2009, INFLAMM BOWEL DIS, V15, P93, DOI 10.1002/ibd.20582
   Boright AP, 1998, ATHEROSCLEROSIS, V139, P131, DOI 10.1016/S0021-9150(98)00071-9
   Bornscheuer UT, 2004, ANGEW CHEM INT EDIT, V43, P6032, DOI 10.1002/anie.200460416
   Bourquard N, 2008, PROTEINS CELL REGUL, V6, P103, DOI 10.1007/978-1-4020-6561-3_7
   Brophy VH, 2001, PHARMACOGENETICS, V11, P77, DOI 10.1097/00008571-200102000-00009
   BURLINA A, 1974, CLIN BIOCHEM, V7, P202, DOI 10.1016/S0009-9120(74)91914-6
   BURLINA A, 1977, EUR J CLIN INVEST, V7, P17, DOI 10.1111/j.1365-2362.1977.tb01564.x
   Cabana VG, 2003, J LIPID RES, V44, P780, DOI 10.1194/jlr.M200432-JLR200
   Calabresi L, 2002, ARTERIOSCL THROM VAS, V22, P656, DOI 10.1161/hq0402.105901
   Camps J, 2007, CLIN CHIM ACTA, V386, P114, DOI 10.1016/j.cca.2007.07.016
   Carmine A, 2002, MOVEMENT DISORD, V17, P764, DOI 10.1002/mds.10172
   Chait A, 2005, J LIPID RES, V46, P389, DOI 10.1194/jlr.R400017-JLR200
   Clarimon J, 2004, NEUROSCI LETT, V367, P168, DOI 10.1016/j.neulet.2004.05.108
   Clay MA, 2001, ATHEROSCLEROSIS, V157, P23, DOI 10.1016/S0021-9150(00)00659-6
   COCKERILL GW, 1995, ARTERIOSCL THROM VAS, V15, P1987, DOI 10.1161/01.ATV.15.11.1987
   Cockerill GW, 2001, FASEB J, V15, P1941, DOI 10.1096/fj.01-0075com
   Cockerill GW, 2001, CIRCULATION, V103, P108
   Coll B, 2005, AIDS, V19, P1877, DOI 10.1097/01.aids.0000183516.22266.dd
   Coll B, 2006, CYTOKINE, V34, P51, DOI 10.1016/j.cyto.2006.03.013
   Copley SD, 2003, CURR OPIN CHEM BIOL, V7, P265, DOI 10.1016/S1367-5931(03)00032-2
   Costa LG, 2005, BIOCHEM PHARMACOL, V69, P541, DOI 10.1016/j.bcp.2004.08.027
   Costa LG, 2005, CLIN CHIM ACTA, V352, P37, DOI 10.1016/j.cccn.2004.09.019
   Datta G, 2001, J LIPID RES, V42, P1096
   Davies HG, 1996, NAT GENET, V14, P334, DOI 10.1038/ng1196-334
   DEAKIN SP, 2004, CLIN SCI, V107, P425
   Demirdögen BC, 2008, CLIN BIOCHEM, V41, P1, DOI 10.1016/j.clinbiochem.2007.08.010
   DIEPGEN TL, 1986, ARCH TOXICOL, P154
   Dirican M, 2004, J NEPHROL, V17, P813
   Draganov DI, 2000, J BIOL CHEM, V275, P33435, DOI 10.1074/jbc.M004543200
   Draganov DI, 2005, J LIPID RES, V46, P1239, DOI 10.1194/jlr.M400511-JLR200
   Durrington PN, 2004, LANCET, V364, P579, DOI 10.1016/S0140-6736(04)16843-8
   ECKERSON HW, 1983, AM J HUM GENET, V35, P214
   ECKERSON HW, 1983, AM J HUM GENET, V35, P1126
   EHRENWALD E, 1994, J CLIN INVEST, V93, P1493, DOI 10.1172/JCI117127
   Elkiran ET, 2007, BMC CANCER, V7, DOI 10.1186/1471-2407-7-48
   ERDOES EG, 1961, NATURE, V190, P716, DOI 10.1038/190716a0
   Erlich PM, 2006, HUM MOL GENET, V15, P77, DOI 10.1093/hmg/ddi428
   ESTERBAUER H, 1990, METHOD ENZYMOL, V186, P407
   Farrer LA, 1997, NEUROLOGIST, V3, P13, DOI 10.1097/00127893-199701000-00003
   Feingold KR, 1998, ATHEROSCLEROSIS, V139, P307, DOI 10.1016/S0021-9150(98)00084-7
   Ferré N, 2005, CLIN CHIM ACTA, V361, P206, DOI 10.1016/j.cccn.2005.05.024
   Ferré N, 2005, CLIN CHEM, V51, P922, DOI 10.1373/clinchem.2005.048231
   Ferré N, 2002, CLIN CHEM, V48, P261
   Ferré N, 2002, CLIN BIOCHEM, V35, P197, DOI 10.1016/S0009-9120(02)00295-3
   Ferré N, 2001, METABOLISM, V50, P997, DOI 10.1053/meta.2001.25589
   Ferré N, 2006, J HEPATOL, V45, P51, DOI 10.1016/j.jhep.2005.12.018
   Ferretti G, 2005, MULT SCLER J, V11, P677, DOI 10.1191/1352458505ms1240oa
   Franco-Pons N, 2008, J GASTROINTEST SURG, V12, P891, DOI 10.1007/s11605-008-0502-2
   Furlong CE, 2008, PROTEINS CELL REGUL, V6, P3, DOI 10.1007/978-1-4020-6561-3_1
   FURLONG CE, 1989, ANAL BIOCHEM, V180, P242, DOI 10.1016/0003-2697(89)90424-7
   Gaidukov L, 2007, J LIPID RES, V48, P1637, DOI 10.1194/jlr.D600045-JLR200
   Gaidukov L, 2006, J LIPID RES, V47, P2492, DOI 10.1194/jlr.M600297-JLR200
   Garin MCB, 1997, J CLIN INVEST, V99, P62, DOI 10.1172/JCI119134
   GARIN MCB, 1994, BIOCHEM J, V304, P549, DOI 10.1042/bj3040549
   GIL F, 1993, CHEM-BIOL INTERACT, V87, P69, DOI 10.1016/0009-2797(93)90026-U
   GIL F, 1993, CHEM-BIOL INTERACT, V87, P149, DOI 10.1016/0009-2797(93)90036-X
   Gonzalvo MC, 1997, CHEM-BIOL INTERACT, V105, P169, DOI 10.1016/S0009-2797(97)00046-X
   GORDON DJ, 1989, CIRCULATION, V79, P8, DOI 10.1161/01.CIR.79.1.8
   Guthold M, 2004, BIOPHYS J, V87, P4226, DOI 10.1529/biophysj.104.042333
   HAAGEN L, 1992, EUR J CLIN CHEM CLIN, V30, P391
   Han CY, 2006, ARTERIOSCL THROM VAS, V26, P1806, DOI 10.1161/01.ATV.0000227472.70734.ad
   Harel M, 2004, NAT STRUCT MOL BIOL, V11, P412, DOI 10.1038/nsmb767
   HASSETT C, 1991, BIOCHEMISTRY-US, V30, P10141, DOI 10.1021/bi00106a010
   He XM, 2006, CHINESE MED J-PEKING, V119, P1204, DOI 10.1097/00029330-200607020-00013
   Horke S, 2007, CIRCULATION, V115, P2055, DOI 10.1161/CIRCULATIONAHA.106.681700
   Horke S, 2008, BIOCHEM J, V416, P395, DOI 10.1042/BJ20080775
   HUANG YS, 1994, BIOCHEM PHARMACOL, V48, P1273
   Jakubowski H, 2000, J BIOL CHEM, V275, P3957, DOI 10.1074/jbc.275.6.3957
   James RW, 2006, CLIN CHEM LAB MED, V44, P1052, DOI 10.1515/CCLM.2006.207
   James RW, 2000, DIABETES, V49, P1390, DOI 10.2337/diabetes.49.8.1390
   James RW, 1998, ATHEROSCLEROSIS, V139, P77, DOI 10.1016/S0021-9150(98)00058-6
   Janel N, 2006, BIOCHEM BIOPH RES CO, V346, P1303, DOI 10.1016/j.bbrc.2006.06.048
   Jaouad L, 2006, ATHEROSCLEROSIS, V185, P191, DOI 10.1016/j.atherosclerosis.2005.06.012
   Jarvik GP, 2000, ARTERIOSCL THROM VAS, V20, P2441, DOI 10.1161/01.ATV.20.11.2441
   Jarvik GP, 2002, ARTERIOSCL THROM VAS, V22, P1329, DOI 10.1161/01.ATV.0000027101.40323.3A
   JENSEN RA, 1976, ANNU REV MICROBIOL, V30, P409, DOI 10.1146/annurev.mi.30.100176.002205
   Johannes TW, 2006, CURR OPIN MICROBIOL, V9, P261, DOI 10.1016/j.mib.2006.03.003
   Kalback W, 2004, NEUROL RES, V26, P525, DOI 10.1179/016164104225017668
   Kalogerakis G, 2005, CLIN SCI, V108, P497, DOI 10.1042/CS20040312
   Kaur J, 2006, CRIT REV BIOTECHNOL, V26, P165, DOI 10.1080/07388550600851423
   KAWAI H, 1990, CLIN CHIM ACTA, V188, P177, DOI 10.1016/0009-8981(90)90162-L
   KAWAI H, 1991, CLIN CHIM ACTA, V202, P219, DOI 10.1016/0009-8981(91)90052-E
   Kazlauskas RJ, 2005, CURR OPIN CHEM BIOL, V9, P195, DOI 10.1016/j.cbpa.2005.02.008
   Kelada SN, 2003, J NEUROL NEUROSUR PS, V74, P546, DOI 10.1136/jnnp.74.4.546
   Khersonsky O, 2006, J BIOL CHEM, V281, P7649, DOI 10.1074/jbc.M512594200
   Khersonsky O, 2006, CHEMBIOCHEM, V7, P49, DOI 10.1002/cbic.200500334
   Khersonsky O, 2005, BIOCHEMISTRY-US, V44, P6371, DOI 10.1021/bi047440d
   Khersonsky O, 2006, CURR OPIN CHEM BIOL, V10, P498, DOI 10.1016/j.cbpa.2006.08.011
   Khovidhunkit W, 2000, J INFECT DIS, V181, pS462, DOI 10.1086/315611
   Kilic SS, 2005, WORLD J GASTROENTERO, V11, P7351, DOI 10.3748/wjg.v11.i46.7351
   Kiss E, 2007, ANN NY ACAD SCI, V1108, P83, DOI 10.1196/annals.1422.009
   La Du B.N., 1992, PHARMACOGENETICS DRU, P51
   La Du BN, 1999, CHEM-BIOL INTERACT, V119, P379, DOI 10.1016/S0009-2797(99)00049-6
   Landau R, 2008, COMPUT SCI ENG, V10, P9
   Lee HG, 2005, INT J EXP PATHOL, V86, P133, DOI 10.1111/j.0959-9673.2005.00429.x
   Leviev I, 2000, ARTERIOSCL THROM VAS, V20, P516, DOI 10.1161/01.ATV.20.2.516
   Leviev I, 1997, ARTERIOSCL THROM VAS, V17, P2935, DOI 10.1161/01.ATV.17.11.2935
   Leviev I, 2001, DIABETOLOGIA, V44, P1177, DOI 10.1007/s001250100610
   Li HL, 2003, J MOL MED, V81, P766, DOI 10.1007/s00109-003-0481-4
   Li WF, 2000, PHARMACOGENETICS, V10, P767, DOI 10.1097/00008571-200012000-00002
   Liao ZH, 2003, AIDS RES HUM RETROV, V19, P675, DOI 10.1089/088922203322280900
   Liu YF, 2008, FREE RADICAL BIO MED, V45, P743, DOI 10.1016/j.freeradbiomed.2008.05.024
   Mackness B, 1998, BIOCHEM BIOPH RES CO, V247, P443, DOI 10.1006/bbrc.1998.8803
   Mackness B, 2000, EUR J CLIN INVEST, V30, P4
   Mackness B, 1999, LANCET, V353, P468, DOI 10.1016/S0140-6736(98)05105-8
   Mackness B, 2004, BIOCHEM BIOPH RES CO, V318, P680, DOI 10.1016/j.bbrc.2004.04.056
   Mackness B, 2003, CIRCULATION, V107, P2775, DOI 10.1161/01.CIR.0000070954.00271.13
   Mackness B, 1997, ARTERIOSCL THROM VAS, V17, P1233, DOI 10.1161/01.ATV.17.7.1233
   MACKNESS B, 2001, ARTERIOSCLER THROMB, V21, P1221
   Mackness B, 2006, ARTERIOSCL THROM VAS, V26, P1545, DOI 10.1161/01.ATV.0000222924.62641.aa
   MACKNESS MI, 1991, FEBS LETT, V286, P152, DOI 10.1016/0014-5793(91)80962-3
   Mackness MI, 1997, FEBS LETT, V416, P377, DOI 10.1016/S0014-5793(97)01243-X
   Mackness MI, 1998, ATHEROSCLEROSIS, V136, P195, DOI 10.1016/S0021-9150(97)00197-4
   MACKNESS MI, 1993, ATHEROSCLEROSIS, V104, P129, DOI 10.1016/0021-9150(93)90183-U
   Mackness MI, 1998, BIOCHEM BIOPH RES CO, V242, P249, DOI 10.1006/bbrc.1997.7872
   Mackness MI, 2000, CURR OPIN LIPIDOL, V11, P383, DOI 10.1097/00041433-200008000-00007
   Marathe GK, 2003, J BIOL CHEM, V278, P3937, DOI 10.1074/jbc.M211126200
   Marsillach J, 2008, PROTEINS CELL REGUL, V6, P187, DOI 10.1007/978-1-4020-6561-3_12
   Marsillach J, 2008, FREE RADICAL BIO MED, V45, P146, DOI 10.1016/j.freeradbiomed.2008.03.023
   Marsillach J, 2007, CLIN BIOCHEM, V40, P645, DOI 10.1016/j.clinbiochem.2007.01.020
   Marsillach J, 2007, CLIN EXP PHARMACOL P, V34, P347, DOI 10.1111/j.1440-1681.2007.04552.x
   Martín-Campos JM, 2002, J LIPID RES, V43, P115
   Mastorikou M, 2006, DIABETES, V55, P3099, DOI 10.2337/db06-0723
   Matsunaga T, 2001, BIOCHEM BIOPH RES CO, V287, P714, DOI 10.1006/bbrc.2001.5625
   MCELVEEN J, 1986, CLIN CHEM, V32, P671
   Mertens A, 2003, CIRCULATION, V107, P1640, DOI 10.1161/01.CIR.0000056523.08033.9F
   Mohs RC, 2005, GENES BRAIN BEHAV, V4, P129, DOI 10.1111/j.1601-183X.2004.00112.x
   Moore RE, 2005, CIRC RES, V97, P763, DOI 10.1161/01.RES.0000185320.82962.F7
   Navab M, 1997, J CLIN INVEST, V99, P2005, DOI 10.1172/JCI119369
   Navab M, 2000, J LIPID RES, V41, P1481
   Navab M, 2005, CIRC RES, V97, P524, DOI 10.1161/01.RES.0000181229.69508.2f
   Navab M, 2004, CIRCULATION, V109, P3215, DOI 10.1161/01.CIR.0000134275.90823.87
   Navab M, 2004, J LIPID RES, V45, P993, DOI 10.1194/jlr.R400001-JLR200
   NAVAB M, 1991, J CLIN INVEST, V88, P2039, DOI 10.1172/JCI115532
   Navab M, 2001, ARTERIOSCL THROM VAS, V21, P481, DOI 10.1161/01.ATV.21.4.481
   Navab M, 2006, NAT CLIN PRACT ENDOC, V2, P504, DOI 10.1038/ncpendmet0245
   Navab M, 2007, J CLIN LIPIDOL, V1, P142, DOI 10.1016/j.jacl.2007.03.002
   Negre-Salvayre A, 2006, FREE RADICAL BIO MED, V41, P1031, DOI 10.1016/j.freeradbiomed.2006.07.006
   Ng CJ, 2007, ARTERIOSCL THROM VAS, V27, P1368, DOI 10.1161/ATVBAHA.106.134189
   Ng CJ, 2006, MOL GENET METAB, V89, P368, DOI 10.1016/j.ymgme.2006.07.004
   Ng CJ, 2006, J BIOL CHEM, V281, P29491, DOI 10.1074/jbc.M605379200
   Ng CJ, 2005, FREE RADICAL BIO MED, V38, P153, DOI 10.1016/j.freeradbiomed.2004.09.035
   Ng CJ, 2001, J BIOL CHEM, V276, P44444, DOI 10.1074/jbc.M105660200
   Ng DS, 2008, CARDIOVASC PATHOL, V17, P226, DOI 10.1016/j.carpath.2007.10.001
   Nguyen DH, 2000, J VIROL, V74, P3264, DOI 10.1128/JVI.74.7.3264-3272.2000
   Nofer JR, 2002, ATHEROSCLEROSIS, V161, P1, DOI 10.1016/S0021-9150(01)00651-7
   O'Brien PJ, 1999, CHEM BIOL, V6, pR91, DOI 10.1016/S1074-5521(99)80033-7
   Oda MN, 2002, BIOCHEM BIOPH RES CO, V290, P921, DOI 10.1006/bbrc.2001.6295
   OWENS RJ, 1990, J CLIN INVEST, V86, P1142, DOI 10.1172/JCI114819
   Ozer EA, 2005, FEMS MICROBIOL LETT, V253, P29, DOI 10.1016/j.femsle.2005.09.023
   Padungtod C, 1999, AM J IND MED, V36, P379, DOI 10.1002/(SICI)1097-0274(199909)36:3<379::AID-AJIM5>3.0.CO;2-8
   Paragh G, 2002, EUR ARCH PSY CLIN N, V252, P63, DOI 10.1007/s004060200013
   Parola M, 1999, ANTIOXID REDOX SIGN, V1, P255, DOI 10.1089/ars.1999.1.3-255
   Parra S, 2007, ATHEROSCLEROSIS, V194, P175, DOI 10.1016/j.atherosclerosis.2006.07.024
   PELLIN MC, 1990, NEUROTOXICOL TERATOL, V12, P611, DOI 10.1016/0892-0362(90)90071-J
   Pérez-Herrera N, 2008, TOXICOL APPL PHARM, V230, P261, DOI 10.1016/j.taap.2008.02.021
   Pola R, 2005, NEUROSCI LETT, V382, P338, DOI 10.1016/j.neulet.2005.03.027
   Pola R, 2003, DEMENT GERIATR COGN, V15, P88, DOI 10.1159/000067975
   PrimoParmo SL, 1996, GENOMICS, V33, P498, DOI 10.1006/geno.1996.0225
   Rao MN, 2003, METABOLISM, V52, P1287, DOI 10.1016/S0026-0495(03)00191-4
   Reddy ST, 2001, ARTERIOSCL THROM VAS, V21, P542, DOI 10.1161/01.ATV.21.4.542
   Ribas V, 2004, CIRC RES, V95, P789, DOI 10.1161/01.RES.0000146031.94850.5f
   Richter R., 2004, Current Protocols in Toxicology, p4.12.11
   Rodrigo L, 1997, BIOCHEM J, V321, P595, DOI 10.1042/bj3210595
   Rodrigo L, 2001, BIOCHEM J, V354, P1, DOI 10.1042/0264-6021:3540001
   Rodrigo L, 2001, CHEM-BIOL INTERACT, V137, P123, DOI 10.1016/S0009-2797(01)00225-3
   Roest M, 2008, PROTEINS CELL REG, V6, P139, DOI 10.1007/978-1-4020-6561-3_9
   Roher AE, 2004, STROKE, V35, P2623, DOI 10.1161/01.STR.0000143317.70478.b3
   Rose H, 2006, METABOLISM, V55, P90, DOI 10.1016/j.metabol.2005.07.012
   Rosenblat M, 2006, J BIOL CHEM, V281, P7657, DOI 10.1074/jbc.M512595200
   Rosenblat M, 2005, ATHEROSCLEROSIS, V179, P69, DOI 10.1016/j.atherosclerosis.2004.10.028
   Rosenblat M, 2003, ARTERIOSCL THROM VAS, V23, P468, DOI 10.1161/01.ATV.0000059385.95664.4D
   Rosenblat M., 2006, ATHEROSCLEROSIS, V187, p74.
   Rothem L, 2007, FREE RADICAL BIO MED, V43, P730, DOI 10.1016/j.freeradbiomed.2007.05.003
   Rozenberg O, 2003, FREE RADICAL BIO MED, V34, P774, DOI 10.1016/S0891-5849(02)01429-6
   Rozenberg O, 2008, FREE RADICAL BIO MED, V44, P1951, DOI 10.1016/j.freeradbiomed.2008.02.012
   Rozenberg O, 2006, BIOCHEM BIOPH RES CO, V351, P492, DOI 10.1016/j.bbrc.2006.10.059
   RUIZ J, 1995, LANCET, V346, P869, DOI 10.1016/S0140-6736(95)92709-3
   Saeed M, 2006, NEUROLOGY, V67, P771, DOI 10.1212/01.wnl.0000227187.52002.88
   SAMOKYSZYN VM, 1989, J BIOL CHEM, V264, P21
   Sanghera DK, 1998, AM J HUM GENET, V62, P36, DOI 10.1086/301669
   Sangvanich P, 2003, BIOCHEM BIOPH RES CO, V300, P501, DOI 10.1016/S0006-291X(02)02849-8
   Scacchi R, 2003, NEUROSCI LETT, V339, P17, DOI 10.1016/S0304-3940(02)01437-4
   Sebastiani G, 2006, WORLD J GASTROENTERO, V12, P3682, DOI 10.3748/wjg.v12.i23.3682
   Serrato M, 1995, J CLIN INVEST, V96, P3005, DOI 10.1172/JCI118373
   Shamir R, 2005, FREE RADICAL BIO MED, V39, P336, DOI 10.1016/j.freeradbiomed.2005.03.016
   Shi JJ, 2004, MOL BRAIN RES, V120, P201, DOI 10.1016/j.molbrainres.2003.10.018
   Shih DM, 2007, CIRC RES, V100, P1200, DOI 10.1161/01.RES.0000264499.48737.69
   Shih DM, 1998, NATURE, V394, P284, DOI 10.1038/28406
   Shih DM, 2000, J BIOL CHEM, V275, P17527, DOI 10.1074/jbc.M910376199
   Shin BS, 2008, ACTA NEUROL SCAND, V117, P237, DOI 10.1111/j.1600-0404.2007.00929.x
   Sierksma A, 2002, ALCOHOL CLIN EXP RES, V26, P1430, DOI 10.1097/01.ALC.0000030639.57507.60
   Simpson KJ, 2003, CLIN SCI, V104, P47, DOI 10.1042/CS20020137
   Slowik A, 2006, NEUROLOGY, V67, P766, DOI 10.1212/01.wnl.0000219565.32247.11
   Sorenson RC, 1995, GENOMICS, V30, P431, DOI 10.1006/geno.1995.1261
   STAMLER J, 1993, DIABETES CARE, V16, P434, DOI 10.2337/diacare.16.2.434
   Standridge JB, 2004, CLIN THER, V26, P615, DOI 10.1016/S0149-2918(04)90064-1
   Stevens VL, 2008, PROSTATE, V68, P1336, DOI 10.1002/pros.20796
   Stevens VL, 2006, CANCER EPIDEM BIOMAR, V15, P1226, DOI 10.1158/1055-9965.EPI-05-0930
   Stoltz DA, 2008, J CLIN INVEST, V118, P3123, DOI 10.1172/JCI35147
   Suchocka Z, 2006, J PHARMACEUT BIOMED, V42, P113, DOI 10.1016/j.jpba.2006.02.015
   Sugano M, 2000, BIOCHEM BIOPH RES CO, V272, P872, DOI 10.1006/bbrc.2000.2877
   TAHL DR, 2003, J NEUROPATHOL EXP NE, V62, P1287
   Tavori H, 2008, BIOORGAN MED CHEM, V16, P7504, DOI 10.1016/j.bmc.2008.06.008
   Teiber JF, 2004, J LIPID RES, V45, P2260, DOI 10.1194/jlr.M400213-JLR200
   Teiber JF, 2003, BIOCHEM PHARMACOL, V66, P887, DOI 10.1016/S0006-2952(03)00401-5
   Teiber JF, 2007, ARCH BIOCHEM BIOPHYS, V461, P24, DOI 10.1016/j.abb.2007.02.015
   Tripi LM, 2006, ARTHRITIS RHEUM-US, V54, P1928, DOI 10.1002/art.21889
   Tward A, 2002, CIRCULATION, V106, P484, DOI 10.1161/01.CIR.0000023623.87083.4F
   Valdmanis PN, 2008, NEUROLOGY, V71, P514, DOI 10.1212/01.wnl.0000324997.21272.0c
   Van Lenten BJ, 2007, J LIPID RES, V48, P2344, DOI 10.1194/jlr.M700138-JLR200
   Van Lenten BJ, 2006, ARTERIOSCL THROM VAS, V26, P1687, DOI 10.1161/01.ATV.0000232522.47018.a6
   VanLenten BJ, 1995, J CLIN INVEST, V96, P2758, DOI 10.1172/JCI118345
   VANTIMBERGEN TM, 2006, NETH J MED, V64, P34
   Verreth W, 2004, CIRCULATION, V110, P3259, DOI 10.1161/01.CIR.0000147614.85888.7A
   Wang J, 2000, MOVEMENT DISORD, V15, P1265, DOI 10.1002/1531-8257(200011)15:6<1265::AID-MDS1034>3.0.CO;2-0
   Watson AD, 1995, J CLIN INVEST, V96, P2882, DOI 10.1172/JCI118359
   Wheeler JG, 2004, LANCET, V363, P689, DOI 10.1016/S0140-6736(04)15642-0
   Xu Gen-Yun, 2005, Hepatobiliary Pancreat Dis Int, V4, P178
   Zamara E, 2004, J HEPATOL, V40, P60, DOI 10.1016/S0168-8278(03)00480-X
   Zintzaras E, 2004, J HUM GENET, V49, P474, DOI 10.1007/s10038-004-0176-x
   Zuliani G, 2001, ACTA NEUROL SCAND, V103, P304, DOI 10.1034/j.1600-0404.2001.103005304.x
NR 255
TC 221
Z9 236
U1 0
U2 20
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1040-8363
EI 1549-781X
J9 CRIT REV CL LAB SCI
JI Crit. Rev. Clin. Lab. Sci.
PY 2009
VL 46
IS 2
BP 83
EP 106
AR PII 909183322
DI 10.1080/10408360802610878
PG 24
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 413TC
UT WOS:000263814400002
PM 19255916
DA 2025-06-11
ER

PT J
AU Liao, D
   Mo, L
   Chen, M
AF Liao, Diying
   Mo, Lili
   Chen, Maowei
TI The Effectiveness of Dance Interventions on Health-Related Outcomes in
   Perimenopausal, Menopausal, and Postmenopausal Women: A Systematic
   Review and Meta-Analysis
SO HEALTHCARE
LA English
DT Review
DE dance intervention; health-related outcomes; meta-analysis; menopausal
   symptoms; systematic review; women
ID METABOLIC SYNDROME; THERAPY; BENEFITS; BIAS
AB Background/Objectives: Dance intervention, as a non-pharmacological therapy, has shown promising potential in alleviating menopausal symptoms among perimenopausal, menopausal, and postmenopausal women. However, a systematic evaluation of its overall effectiveness based on existing trials remains unavailable. This study aims to investigate the effectiveness of dance intervention on health-related outcomes in perimenopausal, menopausal, and postmenopausal women through a systematic review and meta-analysis. Methods: This study systematically searched the relevant databases on 18 October 2024. The risk of bias was assessed using the Cochrane RoB 2 and ROBINS-I tools. Meta-analysis was performed using Review Manager version 5.4. software. For results unsuitable for meta-analysis, narrative synthesis was conducted. The study was registered in PROSPERO (number: CRD42024613134). Results: Meta-analysis demonstrated significant positive effects of dance intervention on psychological symptoms, including depression (I-2 = 87%, p < 0.001), anxiety (I-2 = 90%, p = 0.01), vitality (I-2 = 0%, p = 0.03), interpersonal relationships (I-2 = 0%, p < 0.001), and somatization (I-2 = 85%, p = 0.01), in menopausal women, but no significant impact was observed on psychotic symptoms (I-2 = 89%, p = 0.33). However, the high heterogeneity suggests the presence of potential confounding factors among studies. Sensitivity analysis indicated that the flexibility of the intervention protocol and intra-group differences among participants may have been the main sources of heterogeneity. Further subgroup analysis revealed that interventions conducted less than three times per week had significant effects on depressive symptoms (SMD = -1.93), while a total intervention duration of <= 1800 min significantly improved anxiety symptoms (SMD = -2.15). Conclusions: Dance interventions have significant positive effects on health-related outcomes in perimenopausal, menopausal, and postmenopausal women, except for psychotic symptoms, offering a promising intervention option for clinical practice.
C1 [Liao, Diying; Mo, Lili] Kangwon Natl Univ, Grad Sch Global Convergence, Chunchon 24341, South Korea.
   [Chen, Maowei] Kangwon Natl Univ, Dept Global Convergence, Chunchon 24341, South Korea.
C3 Kangwon National University; Kangwon National University
RP Chen, M (corresponding author), Kangwon Natl Univ, Dept Global Convergence, Chunchon 24341, South Korea.
EM ldy9074532748@163.com; m17307149375@163.com; muwi@kangwon.ac.kr
RI Chen, Maowei/IXW-6804-2023
OI Mo, Lili/0009-0007-7718-2948; Chen, Maowei/0000-0002-7398-4368
CR Abu-Odah H, 2024, SUPPORT CARE CANCER, V32, DOI 10.1007/s00520-024-08431-4
   Araneta MRG, 2015, J SPORT MED PHYS FIT, V55, P1227
   Ares-Benitez I, 2022, COMPLEMENT THER CLIN, V49, DOI 10.1016/j.ctcp.2022.101662
   Behrends A., 2016, European psychotherapy, V13, P99
   Borenstein M., 2009, INTRO META ANAL, DOI DOI 10.1002/9780470743386
   Brodie J., 2004, Journal of Dance Education, V4, P80, DOI DOI 10.1080/15290824.2004.10387263
   Cardozo L, 1998, OBSTET GYNECOL, V92, P722, DOI 10.1016/S0029-7844(98)00175-6
   Chen TT, 2022, COMPLEMENT THER CLIN, V47, DOI 10.1016/j.ctcp.2022.101565
   clinicaltrials, Acute Physiological Effects of Greek Traditional Dancing
   cniw, Menopausal Women-Care for Your Family
   Dabrowska-Galas M, 2019, MEDICINA-LITHUANIA, V55, DOI 10.3390/medicina55080466
   Dimache AM, 2021, NUTRIENTS, V13, DOI 10.3390/nu13062118
   Duberg A, 2020, J INT MED RES, V48, DOI 10.1177/0300060520902610
   Durmus D, 2009, JOINT BONE SPINE, V76, P150, DOI 10.1016/j.jbspin.2008.06.013
   EASTERBROOK PJ, 1991, LANCET, V337, P867, DOI 10.1016/0140-6736(91)90201-Y
   Egger M, 1997, BMJ-BRIT MED J, V315, P629, DOI 10.1136/bmj.315.7109.629
   Gómez-Lozano S, 2024, HEALTHCARE-BASEL, V12, DOI 10.3390/healthcare12030402
   Gordon AJ, 2014, AM J DANCE THER, V36, P60, DOI 10.1007/s10465-014-9165-6
   Janyacharoen T, 2015, J PHYS THER SCI, V27, P2569, DOI 10.1589/jpts.27.2569
   Ji HL, 2024, CURR PSYCHOL, V43, P24557, DOI 10.1007/s12144-024-06124-z
   소순희, 2012, [The Journal of Oriental Obstetrics ＆ Gynecology, 대한한방부인과학회지], V25, P154
   Kim J.-H., 2023, Arts Cult, V4, P61
   Kim JW, 2012, METAB SYNDR RELAT D, V10, P452, DOI 10.1089/met.2012.0036
   Kim M.-H., 2006, Korea Sports Res, V17, P731
   Kissler K, 2016, J MIDWIFERY WOM HEAL, V61, P507, DOI 10.1111/jmwh.12420
   Klonizakis M, 2014, MENOPAUSE, V21, P1099, DOI [10.1097/GME.0000000000000208, 10.1097/gme.0000000000000208]
   Koch SC, 2007, ART PSYCHOTHER, V34, P340, DOI 10.1016/j.aip.2007.07.001
   Krasnow D, 1997, MED PROBL PERFORM AR, V12, P3
   LEY CJ, 1992, AM J CLIN NUTR, V55, P950, DOI 10.1093/ajcn/55.5.950
   Li Y, 2024, HEALTHCARE-BASEL, V12, DOI 10.3390/healthcare12131309
   Lialy HE, 2023, BMC WOMENS HEALTH, V23, DOI 10.1186/s12905-023-02515-9
   Lopez-Nieves I, 2022, AM J DANCE THER, V44, P241, DOI 10.1007/s10465-022-09368-z
   Machado ED, 2024, DISABIL REHABIL, V46, P1485, DOI 10.1080/09638288.2023.2200259
   Maki PM, 2024, MENOPAUSE, V31, P724, DOI 10.1097/GME.0000000000002386
   Martins JBB, 2025, RES Q EXERCISE SPORT, V96, P316, DOI 10.1080/02701367.2024.2406401
   motaean, Menopause Diagnosis and Treatment
   ncbi.nlm.nih, Management of Menopause-Related Symptoms: Summary
   Pan L., 2004, J. Yulin Teach. Coll, V5, P80
   PASQUALI R, 1994, INT J OBESITY, V18, P614
   Rodrigues-Krause J, 2018, EXP GERONTOL, V114, P67, DOI 10.1016/j.exger.2018.10.015
   Rossmeissl A, 2016, SPORTS, V4, DOI 10.3390/sports4010005
   Rossouw JE, 2002, JAMA-J AM MED ASSOC, V288, P321, DOI 10.1001/jama.288.3.321
   Salari N, 2023, SLEEP BREATH, V27, P1883, DOI 10.1007/s11325-023-02793-5
   Shorey S, 2020, J ADV NURS, V76, P1098, DOI 10.1111/jan.14304
   Sterne JAC, 2019, BMJ-BRIT MED J, V366, DOI 10.1136/bmj.l4898
   Sterne JAC, 2016, BMJ-BRIT MED J, V355, DOI 10.1136/bmj.i4919
   Sternfeld B, 2005, MED SCI SPORT EXER, V37, P1195, DOI 10.1249/01.mss.0000170083.41186.b1
   Teede HJ, 2003, BEST PRACT RES CL EN, V17, P73, DOI 10.1016/S1521-690X(02)00083-0
   Teixeira-Machado L, 2019, NEUROSCI BIOBEHAV R, V96, P232, DOI 10.1016/j.neubiorev.2018.12.010
   Tomaz GG, 2024, MENOPAUSE, V31, P194, DOI 10.1097/GME.0000000000002318
   Toth MJ, 2000, ANN NY ACAD SCI, V904, P502
   Toth MJ, 2000, INT J OBESITY, V24, P226, DOI 10.1038/sj.ijo.0801118
   Waer FB, 2024, APPL SCI-BASEL, V14, DOI 10.3390/app14072886
   Wang AB, 2021, REV BRAS MED ESPORTE, V27, P464, DOI 10.1590/1517-8692202127042021_0076
   WebMD Editorial Contributors, Menopause Information
   Xiaoyan L., 2017, Chin. J. Osteoporos, V23, P1063, DOI [10.3969/j.issn.1006-7108.2017.08.018, DOI 10.3969/J.ISSN.1006-7108.2017.08.018]
   Yang X., 2015, J. Shandong Inst. Phys. Educ, V5, P68
   김정하, 2012, [Official Journal of the Koeran Society of Dance Science, 한국무용과학회지], V28, P127
   Zhao H., 2006, Chin. J. Clin. Rehabil, V10, P29
   Zhou Y, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-01489-7
NR 60
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD APR 11
PY 2025
VL 13
IS 8
AR 881
DI 10.3390/healthcare13080881
PG 22
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA 1XP0R
UT WOS:001476051100001
PM 40281829
DA 2025-06-11
ER

PT J
AU Vargas, EA
   Patel, RB
   Medina-Lezama, J
   Chirinos, DA
AF Vargas, Emily A.
   Patel, Ravi B.
   Medina-Lezama, Josefina
   Chirinos, Diana A.
TI Depressive Symptoms Are Associated with Reduced Cardiac Function Among
   Hispanics: Results from the PREVENCION Study
SO INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Depressive symptoms; Cardiac function; Impedance cardiography; Heart
   failure; South American Hispanics
ID PERUVIAN ANDEAN HISPANICS; HEART-FAILURE PATIENTS; METABOLIC SYNDROME;
   HOSPITAL ANXIETY; HEALTH-STATUS; RISK; PREVALENCE; HYPERTENSION;
   DYSFUNCTION; PREDICTORS
AB Background Depressive symptoms are common among patients with heart failure and are often associated with adverse outcomes, including re-hospitalization and mortality. However, little is known about the association between depressive symptoms and subclinical markers of heart failure and cardiac function in community-based samples and little research has focused on South American Hispanics. The current study examined the cross-sectional association between depressive symptoms and cardiac function in South American Hispanic community-based adults. Methods Participants included 527 adults enrolled in the Peruvian Study of Cardiovascular Disease (PREVENCION). Depressive symptoms were assessed with the Hospital Anxiety and Depression Scale (HADS). Markers of cardiac function were assessed by impedance cardiography and included cardiac output, cardiac index, stroke volume, and stroke volume index. Several multiple regression analyses were used to examine the association between depressive symptoms and markers of cardiac function. Results In adjusted analyses, depressive symptoms were associated with reduced cardiac output, cardiac index, stroke volume, and stroke volume index. These associations remained significant between depressive symptoms and cardiac output (beta = - 0.106, p = 0.014), cardiac index (beta = - 0.099, p = 0.029), and stroke volume (beta = - 0.095, p = 0.022), and a trend was still observed between depressive symptoms and stroke index (beta = - 0.083, p = 0.061), even after having controlled for demographic factors (age, gender, education), cardiovascular risk factors (smoking status, body mass index, low- and high-density lipoprotein cholesterol, triglycerides, fasting glucose, serum creatinine), and comorbidities (diabetes mellitus, hypertension, hypercholesterolemia). Conclusions In the PREVENCION sample tested, depressive symptoms were independently associated with cardiac function among Hispanic adults, even above and beyond pertinent factors such as demographic factors, cardiovascular risk factors, and comorbidities. Future studies should determine whether depressive symptoms are prospectively associated with systolic dysfunction, and examine the bio-behavioral pathways of this association.
C1 [Vargas, Emily A.; Patel, Ravi B.; Chirinos, Diana A.] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, 680 Lake Shore Dr, Chicago, IL 60611 USA.
   [Medina-Lezama, Josefina] Santa Maria Catholic Univ, Res Inst, Arequipa, Peru.
C3 Northwestern University; Feinberg School of Medicine; Universidad
   Catolica de Santa Maria
RP Vargas, EA (corresponding author), Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, 680 Lake Shore Dr, Chicago, IL 60611 USA.
EM emily.vargas1@northwestern.edu
RI Patel, Ravi/LCE-3709-2024
OI , Dr. Ravi Patel/0009-0007-6033-2671
FU T32 Research Training Program in Cardiovascular Disease Epidemiology and
   Prevention at Northwestern University, Department of Preventive Medicine
FX EAV and RBP are funded by the T32 Research Training Program in
   Cardiovascular Disease Epidemiology and Prevention at Northwestern
   University, Department of Preventive Medicine.
CR Abramson J, 2001, ARCH INTERN MED, V161, P1725, DOI 10.1001/archinte.161.14.1725
   Bocchi EA, 2013, CURR CARDIOL REV, V9, P147, DOI 10.2174/1573403X11309020007
   Bekelman DB, 2007, J CARD FAIL, V13, P643, DOI 10.1016/j.cardfail.2007.05.005
   Bozkurt B, 2016, CIRCULATION, V134, pE535, DOI 10.1161/CIR.0000000000000450
   Campbell DJ, 2019, EUR J HEART FAIL, V21, P449, DOI 10.1002/ejhf.1381
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   Cotlear D, 2011, DIR DEV, P1, DOI 10.1596/978-0-8213-8487-9
   Escobar JI, 2007, PSYCHOSOM MED, V69, P841, DOI 10.1097/PSY.0b013e31815b007e
   Fan HJ, 2014, PREV MED, V63, P36, DOI 10.1016/j.ypmed.2014.03.007
   Frasure-Smith N, 2005, PSYCHOSOM MED, V67, pS19, DOI 10.1097/01.psy.0000162253.07959.db
   Freedland KE, 2016, PSYCHOSOM MED, V78, P896, DOI 10.1097/PSY.0000000000000346
   GRAUHOLT AM, 1986, SCAND J CLIN LAB INV, V46, P715, DOI 10.3109/00365518609084042
   Halaris A, 2013, CURR PSYCHIAT REP, V15, DOI 10.1007/s11920-013-0400-5
   Joynt KE, 2004, J CARD FAIL, V10, P258, DOI 10.1016/j.cardfail.2003.09.008
   Kannel W B, 2000, Heart Fail Rev, V5, P167
   Kato N, 2012, J CARDIOL, V60, P23, DOI 10.1016/j.jjcc.2012.01.010
   Lam CSP, 2011, CIRCULATION, V124, P24, DOI 10.1161/CIRCULATIONAHA.110.979203
   Lesman-Leegte I, 2006, EUR J HEART FAIL, V8, P634, DOI 10.1016/j.ejheart.2005.11.010
   Lett H, 2008, PSYCHOSOM MED, V70, P444, DOI 10.1097/PSY.0b013e31816c3c5c
   LITWIN SE, 1993, J AM COLL CARDIOL, V22, pA49, DOI 10.1016/0735-1097(93)90463-B
   López-Alvarenga JC, 2002, REV INVEST CLIN, V54, P403
   Medina-Lezama J, 2005, INT J CARDIOL, V105, P198, DOI 10.1016/j.ijcard.2004.12.032
   Medina-Lezama J, 2008, REV PANAM SALUD PUBL, V24, P169, DOI 10.1590/S1020-49892008000900003
   Medina-Lezama J, 2007, DIABETES RES CLIN PR, V78, P270, DOI 10.1016/j.diabres.2007.04.004
   Medina-Lezama J, 2018, J AM HEART ASSOC, V7, DOI 10.1161/JAHA.118.009259
   Medina-Lezama J, 2007, J AM SOC HYPERTENS, V1, P216, DOI 10.1016/j.jash.2007.02.003
   Nair N, 2012, AM J CARDIOL, V109, P768, DOI 10.1016/j.amjcard.2011.10.039
   Newhouse A, 2014, HEART FAIL CLIN, V10, P295, DOI 10.1016/j.hfc.2013.10.004
   PAHO, 2017, HLTH STAT POP MORT A
   Polsky D, 2005, ARCH INTERN MED, V165, P1260, DOI 10.1001/archinte.165.11.1260
   Redfield MM, 2016, NEW ENGL J MED, V375, P1868, DOI 10.1056/NEJMcp1511175
   Ruilope L M, 2017, Hipertens Riesgo Vasc, V34, P50, DOI 10.1016/j.hipert.2016.11.005
   Rumsfeld JS, 2003, J AM COLL CARDIOL, V42, P1811, DOI 10.1016/j.jacc.2003.07.013
   Rutledge T, 2006, J AM COLL CARDIOL, V48, P1527, DOI 10.1016/j.jacc.2006.06.055
   Sherwood A, 2007, ARCH INTERN MED, V167, P367, DOI 10.1001/archinte.167.4.367
   Sokoreli I, 2016, HEART FAIL REV, V21, P49, DOI 10.1007/s10741-015-9517-4
   Song EK, 2009, J CLIN NURS, V18, P1871, DOI 10.1111/j.1365-2702.2008.02722.x
   Sullivan M, 2004, J CARD FAIL, V10, P390, DOI 10.1016/j.cardfail.2004.01.011
   Sullivan M, 2002, ARCH INTERN MED, V162, P1860, DOI 10.1001/archinte.162.16.1860
   Van de Water JM, 2003, CHEST, V123, P2028, DOI 10.1378/chest.123.6.2028
   van den Broek KC, 2011, AM J CARDIOL, V107, P723, DOI 10.1016/j.amjcard.2010.10.055
   Walter FA, 2019, ANN BEHAV MED, V53, P955, DOI 10.1093/abm/kaz006
   Weller SC, 2008, CULT MED PSYCHIAT, V32, P406, DOI 10.1007/s11013-008-9101-7
   Williams SA, 2002, PSYCHOSOM MED, V64, P6, DOI 10.1097/00006842-200201000-00002
   Yancy CW, 2013, CIRCULATION, V128, P1810, DOI 10.1161/CIR.0b013e31829e8807
   Yancy CW, 2013, CIRCULATION, V128, pE240, DOI 10.1161/CIR.0b013e31829e8776
   Yusim A, 2009, WORLD PSYCHIATRY, V8, P178
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 48
TC 1
Z9 1
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1070-5503
EI 1532-7558
J9 INT J BEHAV MED
JI Int. J. Behav. Med.
PD OCT
PY 2021
VL 28
IS 5
BP 531
EP 539
DI 10.1007/s12529-020-09941-1
EA NOV 2020
PG 9
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA UE6IW
UT WOS:000588232300004
PM 33170471
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Desai, P
   Donovan, L
   Janowitz, E
   Kim, JY
AF Desai, Priya
   Donovan, Lorin
   Janowitz, Elizabeth
   Kim, Joon Young
TI The Clinical Utility of Salivary Biomarkers in the Identification of
   Type 2 Diabetes Risk and Metabolic Syndrome
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Review
DE saliva; inflammation; type 2 diabetes; biomarkers; metabolic syndrome;
   oxidative stress
ID C-REACTIVE PROTEIN; SERUM 1,5-ANHYDROGLUCITOL CONCENTRATIONS; 1,5
   ANHYDROGLUCITOL LEVELS; ADIPOSE-SPECIFIC PROTEIN; NECROSIS-FACTOR-ALPHA;
   INSULIN-RESISTANCE; PLASMA ADIPONECTIN; OXIDATIVE STRESS; GLYCEMIC
   CONTROL; LEPTIN LEVELS
AB Type 2 diabetes is traditionally diagnosed by the use of an oral glucose tolerance test and/or HbA1c, both of which require serum collection. Various biomarkers, which are measurable biological substances that provide clinical insight on disease state, have also been effective in the early identification and risk prediction of inflammatory diseases. Measuring biomarker concentrations has traditionally been obtained through serum collection as well. However, numerous biomarkers are detectable in saliva. Salivary analysis has more recently been introduced into research as a potential non-invasive, cost-effective diagnostic for the early identification of type 2 diabetes risk in adults and youth. Therefore, the purpose of this review was to compare 6 established inflammatory biomarkers of type 2 diabetes, in serum and saliva, and determine if similar diagnostic effectiveness is seen in saliva. A lack of standardized salivary analysis, processing, and collection accounts for errors and inconsistencies in conclusive data amongst studies. Proposing a national standardization in salivary analysis, coupled with increased data and research on the utility of saliva as a diagnostic, poses the potential for salivary analysis to be used in diagnostic settings.
C1 [Desai, Priya; Donovan, Lorin; Janowitz, Elizabeth; Kim, Joon Young] Syracuse Univ, Dept Exercise Sci, Womens Bldg 204E,820 Comstock Ave, Syracuse, NY 13244 USA.
C3 Syracuse University
RP Kim, JY (corresponding author), Syracuse Univ, Dept Exercise Sci, Womens Bldg 204E,820 Comstock Ave, Syracuse, NY 13244 USA.
EM jkim291@syr.edu
RI Kim, Joon/I-9690-2016
OI Desai, Priya/0000-0002-0562-2242; Kim, Joon Young/0000-0003-0448-1684
FU Department of Exercise Science at Syracuse University
FX This work was supported by the Department of Exercise Science at
   Syracuse University.
CR Abbasi A, 2014, LANCET DIABETES ENDO, V2, P106, DOI 10.1016/S2213-8587(14)70005-1
   Abel ED, 2001, NATURE, V409, P729, DOI 10.1038/35055575
   Abrahamian H, 2007, EXP CLIN ENDOCR DIAB, V115, P38, DOI 10.1055/s-2007-948213
   AHLUWALIA TS, 2019, FRONT ENDOCRINOL, V10, DOI DOI 10.3389/FENDO.2019.0064920
   Altinova AE, 2007, ENDOCR J, V54, P221, DOI 10.1507/endocrj.K06-021
   Arita Y, 1999, BIOCHEM BIOPH RES CO, V257, P79, DOI 10.1006/bbrc.1999.0255
   Aryan Z, 2018, ANN NUTR METAB, V72, P287, DOI 10.1159/000488537
   Asemi Z, 2013, ANN NUTR METAB, V63, P1, DOI 10.1159/000349922
   Asha M, 2019, J ADV CLIN RES INSIG, V6, P67, DOI [10.15713/ins.jcri.26370., DOI 10.15713/INS.JCRI.26370]
   Bai YY, 2019, EXP CLIN ENDOCR DIAB, V127, P220, DOI 10.1055/s-0043-122142
   Barnes VM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0105181
   Carpenter GH, 2013, ANNU REV FOOD SCI T, V4, P267, DOI 10.1146/annurev-food-030212-182700
   Castañeda S, 2019, CLIN EXP RHEUMATOL, V37, P465
   Cheng KKY, 2007, DIABETES, V56, P1387, DOI 10.2337/db06-1580
   Considine RV, 1996, NEW ENGL J MED, V334, P292, DOI 10.1056/NEJM199602013340503
   Costa PP, 2010, J PERIODONTOL, V81, P384, DOI 10.1902/jop.2009.090510
   Dall TM, 2019, DIABETES CARE, V42, P1661, DOI 10.2337/dc18-1226
   DAWES C, 1993, ANN NY ACAD SCI, V694, P265, DOI 10.1111/j.1749-6632.1993.tb18359.x
   DeFronzo RA, 2009, DIABETES, V58, P773, DOI 10.2337/db09-9028
   Desai GS, 2014, WORLD J DIABETES, V5, P730, DOI 10.4239/wjd.v5.i6.730
   Dorcely Brenda, 2017, Diabetes Metab Syndr Obes, V10, P345, DOI 10.2147/DMSO.S100074
   Dungan KM, 2006, DIABETES CARE, V29, P1214, DOI 10.2337/dc06-1910
   Effoe VS, 2015, DIABETES CARE, V38, P1694, DOI 10.2337/dc15-0221
   Epingeac ME, 2019, REV CHIM-BUCHAREST, V70, P2241
   Esteghamati A, 2009, METAB SYNDR RELAT D, V7, P447, DOI 10.1089/met.2008.0100
   Gaman MA, 2020, WORLD J DIABETES, V11, P193, DOI 10.4239/wjd.v11.i5.193
   Gannage-Yared MH, 2006, EUR J ENDOCRINOL, V155, P167, DOI 10.1530/eje.1.02175
   Gao XL, 2016, PERIODONTOL 2000, V70, P128, DOI 10.1111/prd.12100
   Gariballa S, 2019, BMC ENDOCR DISORD, V19, DOI 10.1186/s12902-019-0386-z
   Goodson JM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0098799
   Hannon TS, 2015, ANN NY ACAD SCI, V1353, P113, DOI 10.1111/nyas.12939
   Hanyu O, 2009, J ATHEROSCLER THROMB, V16, P560, DOI 10.5551/jat.869
   Harder-Lauridsen NM, 2014, AM J PHYSIOL-ENDOC M, V306, pE769, DOI 10.1152/ajpendo.00571.2013
   Harris RBS, 2000, ANNU REV NUTR, V20, P45, DOI 10.1146/annurev.nutr.20.1.45
   Hotta K, 2000, ARTERIOSCL THROM VAS, V20, P1595, DOI 10.1161/01.ATV.20.6.1595
   Hu FB, 2004, DIABETES, V53, P693, DOI 10.2337/diabetes.53.3.693
   Hu FB, 2001, NEW ENGL J MED, V345, P790, DOI 10.1056/NEJMoa010492
   Huang TY, 2019, DIABETES, V68, P281, DOI 10.2337/db18-0892
   Iwamoto Y, 2001, J PERIODONTOL, V72, P774, DOI 10.1902/jop.2001.72.6.774
   Iwata M, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0192609
   Januszewski AS, 2012, DIABETES RES CLIN PR, V95, pE17, DOI 10.1016/j.diabres.2011.09.032
   Kim WJ, 2013, ENDOCRINE, V43, P33, DOI 10.1007/s12020-012-9760-6
   Kim WJ, 2012, DIABETES CARE, V35, P281, DOI 10.2337/dc11-1462
   Lainampetch J, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/9051929
   Lee SW, 2012, J OBSTET GYNAECOL, V32, P73, DOI 10.3109/01443615.2011.618893
   LeGal CS, 1997, FEBS LETT, V404, P185, DOI 10.1016/S0014-5793(97)00125-7
   Lei CT, 2018, J CELL MOL MED, V22, P251, DOI 10.1111/jcmm.13314
   Li JY, 2019, CLIN CHIM ACTA, V494, P52, DOI 10.1016/j.cca.2019.03.006
   Liu W, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000019052
   Loomis SJ, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-42202-0
   Malamud Daniel, 2011, Dent Clin North Am, V55, P159, DOI 10.1016/j.cden.2010.08.004
   Mamali I, 2012, PEPTIDES, V33, P120, DOI 10.1016/j.peptides.2011.11.007
   MITRAKOU A, 1992, NEW ENGL J MED, V326, P22, DOI 10.1056/NEJM199201023260104
   Monea A, 2014, EUR SCI J ONTAL DIS, V10
   Mook-Kanamori DO, 2014, J CLIN ENDOCR METAB, V99, pE479, DOI 10.1210/jc.2013-3596
   Nadeau KJ, 2016, DIABETES CARE, V39, P1635, DOI 10.2337/dc16-1066
   Naidoo T, 2012, CARDIOVASC J AFR, V23, P501, DOI 10.5830/CVJA-2012-058
   Navarro JF, 2006, NEPHROL DIAL TRANSPL, V21, P3428, DOI 10.1093/ndt/gfl469
   Osborn O, 2012, NAT MED, V18, P363, DOI 10.1038/nm.2627
   Pal A, 2010, DIABETES CARE, V33, P252, DOI 10.2337/dc09-1246
   Pan A, 2017, BMC ENDOCR DISORD, V17, DOI 10.1186/s12902-017-0159-5
   Phillips SA, 2003, DIABETES, V52, P667, DOI 10.2337/diabetes.52.3.667
   Randeria SN, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0870-9
   Redman RS, 2016, BIOTECH HISTOCHEM, V91, P77, DOI 10.3109/10520295.2015.1082625
   Reeh H, 2019, CELL COMMUN SIGNAL, V17, DOI 10.1186/s12964-019-0356-0
   Rodrigues KF, 2017, ARCH ENDOCRIN METAB, V61, P438
   Roi A, 2019, DIS MARKERS, V2019, DOI 10.1155/2019/8761860
   Rowley WR, 2017, POPUL HEALTH MANAG, V20, P6, DOI 10.1089/pop.2015.0181
   Ruge T, 2009, METABOLISM, V58, P860, DOI 10.1016/j.metabol.2009.02.010
   Russo GT, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0109702
   Ryo M, 2004, CIRC J, V68, P975, DOI 10.1253/circj.68.975
   Saeedi P, 2019, DIABETES RES CLIN PR, V157, DOI 10.1016/j.diabres.2019.107843
   Santaniemi M, 2006, EUR J ENDOCRINOL, V155, P745, DOI 10.1530/eje.1.02287
   Schmidt MI, 2006, DIABETOLOGIA, V49, P2086, DOI 10.1007/s00125-006-0351-z
   Selvin E, 2014, CLIN CHEM, V60, P1409, DOI 10.1373/clinchem.2014.229427
   Siitonen N, 2011, BMC MED GENET, V12, DOI 10.1186/1471-2350-12-5
   Nunes LAS, 2015, BIOCHEM MEDICA, V25, P177, DOI 10.11613/BM.2015.018
   Spranger J, 2003, DIABETES, V52, P812, DOI 10.2337/diabetes.52.3.812
   Srinivasan M, 2018, BIOCHEM RES INT, V2018, DOI 10.1155/2018/7463796
   STEPHENS JM, 1991, J BIOL CHEM, V266, P21839
   TABISH SA, 2007, INT J HLTH SCI, V1, pR, DOI DOI 10.1515/REVNEURO-2017-0016
   Thanakun S, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-19
   Tiwari Manjul, 2011, J Nat Sci Biol Med, V2, P53, DOI 10.4103/0976-9668.82322
   Tvarijonaviciute A, 2017, J ORAL PATHOL MED, V46, P853, DOI 10.1111/jop.12587
   VINAGRE I, 2014, CARDIOVASC DIABETOL, V13, DOI DOI 10.1186/1475-2840-13-9
   Virkamäki A, 1999, J CLIN INVEST, V103, P931, DOI 10.1172/JCI6609
   Wang LH, 2017, INT J CLIN EXP PATHO, V10, P10515
   Weber MB, 2019, DIABETES CARE, V42, P1612, DOI 10.2337/dci19-0022
   WHITEHEAD TP, 1992, ANN CLIN BIOCHEM, V29, P159, DOI 10.1177/000456329202900206
   Wild S, 2004, DIABETES CARE, V27, P1047, DOI 10.2337/diacare.27.5.1047
   Woo YC, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036868
   Wu YL, 2014, INT J MED SCI, V11, P1185, DOI 10.7150/ijms.10001
   Yadav A, 2013, CLIN CHIM ACTA, V417, P80, DOI 10.1016/j.cca.2012.12.007
   Yamauchi T, 2001, NAT MED, V7, P941, DOI 10.1038/90984
   Yang RH, 2007, CIRC RES, V101, P545, DOI 10.1161/CIRCRESAHA.107.156596
   Yeh Chih-Ko, 2010, Tex Dent J, V127, P651
   Yoon MJ, 2006, DIABETES, V55, P2562, DOI 10.2337/db05-1322
   Yoshizawa JM, 2013, CLIN MICROBIOL REV, V26, P781, DOI 10.1128/CMR.00021-13
   Zulfania, 2020, J Pak Med Assoc, V70, P3, DOI 10.5455/JPMA.301135
NR 99
TC 12
Z9 12
U1 0
U2 16
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2020
VL 13
BP 3587
EP 3599
DI 10.2147/DMSO.S265879
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA OD3QF
UT WOS:000579766700002
PM 33116710
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Guimbaud, JB
   Siskos, AP
   Sakhi, AK
   Heude, B
   Sabidó, E
   Borràs, E
   Keun, H
   Wright, J
   Julvez, J
   Urquiza, J
   Gützkow, KB
   Chatzi, L
   Casas, M
   Bustamante, M
   Nieuwenhuijsen, M
   Vrijheid, M
   López-Vicente, M
   Pascual, MD
   Stratakis, N
   Robinson, O
   Grazuleviciene, R
   Slama, R
   Alemany, S
   Basagaña, X
   Plantevit, M
   Cazabet, R
   Maitre, L
AF Guimbaud, Jean-Baptiste
   Siskos, Alexandros P.
   Sakhi, Amrit Kaur
   Heude, Barbara
   Sabido, Eduard
   Borras, Eva
   Keun, Hector
   Wright, John
   Julvez, Jordi
   Urquiza, Jose
   Gutzkow, Kristine Bjerve
   Chatzi, Leda
   Casas, Maribel
   Bustamante, Mariona
   Nieuwenhuijsen, Mark
   Vrijheid, Martine
   Lopez-Vicente, Monica
   Pascual, Montserrat de Castro
   Stratakis, Nikos
   Robinson, Oliver
   Grazuleviciene, Regina
   Slama, Remy
   Alemany, Silvia
   Basagana, Xavier
   Plantevit, Marc
   Cazabet, Remy
   Maitre, Lea
TI Machine learning-based health environmental-clinical risk scores in
   European children
SO COMMUNICATIONS MEDICINE
LA English
DT Article
ID COHORT PROFILE; MENTAL-HEALTH; CHILDHOOD; EXPOSURE; OBESITY; EXPOSOME;
   OUTCOMES; DISEASE; MOTHER; GENOME
AB Background Early life environmental stressors play an important role in the development of multiple chronic disorders. Previous studies that used environmental risk scores (ERS) to assess the cumulative impact of environmental exposures on health are limited by the diversity of exposures included, especially for early life determinants. We used machine learning methods to build early life exposome risk scores for three health outcomes using environmental, molecular, and clinical data.Methods In this study, we analyzed data from 1622 mother-child pairs from the HELIX European birth cohorts, using over 300 environmental, 100 child peripheral, and 18 mother-child clinical markers to compute environmental-clinical risk scores (ECRS) for child behavioral difficulties, metabolic syndrome, and lung function. ECRS were computed using LASSO, Random Forest and XGBoost. XGBoost ECRS were selected to extract local feature contributions using Shapley values and derive feature importance and interactions.Results ECRS captured 13%, 50% and 4% of the variance in mental, cardiometabolic, and respiratory health, respectively. We observed no significant differences in predictive performances between the above-mentioned methods.The most important predictive features were maternal stress, noise, and lifestyle exposures for mental health; proteome (mainly IL1B) and metabolome features for cardiometabolic health; child BMI and urine metabolites for respiratory health.Conclusions Besides their usefulness for epidemiological research, our risk scores show great potential to capture holistic individual level non-hereditary risk associations that can inform practitioners about actionable factors of high-risk children. As in the post-genetic era personalized prevention medicine will focus more and more on modifiable factors, we believe that such integrative approaches will be instrumental in shaping future healthcare paradigms.
   Growing up in different environments can greatly affect children's health later in life. This research looked at how living in cities, being exposed to chemicals, and other experiences before birth and during childhood, work together to influence children's mental, cardiovascular and respiratory health. We used advanced computer programs to help us understand these effects and estimate health risk scores. These scores are simple numerical measures that help us quantify the likelihood of children developing health issues based on their environmental exposures. Using those scores, the study identified key factors impacting children's health, in particular psycho-social, perceived environmental and prenatal pollutant exposures for mental health. It also revealed complex patterns and interactions between environmental factors. The results highlighted the potential of such risk scores to support the identification of actionable factors in high-risk children, informing tailored prevention measures in healthcare.
   Guimbaud et al. use machine learning in a dataset of 1600 European mother-child pairs to link early-life environmental exposures with children's health. Through the computation of environmental-clinical risk scores, they unveil complex interactions and nonlinear patterns among these factors, underscoring their intricate role in children's health.
C1 [Guimbaud, Jean-Baptiste; Julvez, Jordi; Urquiza, Jose; Casas, Maribel; Bustamante, Mariona; Nieuwenhuijsen, Mark; Vrijheid, Martine; Lopez-Vicente, Monica; Pascual, Montserrat de Castro; Basagana, Xavier; Maitre, Lea] ISGlobal, Barcelona, Spain.
   [Guimbaud, Jean-Baptiste; Cazabet, Remy] Univ Lyon, CNRS, INSA Lyon, UCBL,LIRIS,UMR5205, F-69622 Villeurbanne, France.
   [Guimbaud, Jean-Baptiste; Sabido, Eduard; Borras, Eva; Urquiza, Jose; Casas, Maribel; Bustamante, Mariona; Vrijheid, Martine; Lopez-Vicente, Monica; Pascual, Montserrat de Castro; Basagana, Xavier; Maitre, Lea] Univ Pompeu Fabra UPF, Barcelona, Spain.
   [Guimbaud, Jean-Baptiste] Meersens, Lyon, France.
   [Siskos, Alexandros P.; Keun, Hector] Imperial Coll London, Dept Surg & Canc, Div Canc, Canc Metab & Syst Toxicol Grp, London, England.
   [Sakhi, Amrit Kaur; Gutzkow, Kristine Bjerve] Norwegian Inst Publ Hlth, Oslo, Norway.
   [Heude, Barbara] Univ Paris Cite, Ctr Res Epidemiol & Stat CRESS, Inserm, INRAE, Paris, France.
   [Sabido, Eduard; Borras, Eva] Barcelona Inst Sci & Technol BIST, Ctr Regulacio Genom, Barcelona, Spain.
   [Wright, John] Bradford Inst Hlth Res, Bradford, England.
   [Wright, John] Bradford Teaching Hosp NHS Fdn Trust, Bradford, England.
   [Julvez, Jordi; Urquiza, Jose; Casas, Maribel; Bustamante, Mariona; Vrijheid, Martine; Lopez-Vicente, Monica; Pascual, Montserrat de Castro; Basagana, Xavier; Maitre, Lea] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.
   [Julvez, Jordi] Hosp Univ St Joan Reus, Inst Invest Sanitaria Pere Virgili, Reus, Spain.
   [Chatzi, Leda; Stratakis, Nikos] Univ Southern Calif, Dept Prevent Med, Los Angeles, CA USA.
   [Robinson, Oliver] Imperial Coll London, Ctr Environm & Hlth, Sch Publ Hlth, ed Res Council, London, England.
   [Robinson, Oliver] Imperial Coll London, Mohn Ctr Childrens Hlth & Well being, Sch Publ Hlth, London, England.
   [Grazuleviciene, Regina] Vytautas Magnus Univ, Dept Environm Sci, Kaunas, Lithuania.
   [Slama, Remy] Univ Grenoble Alpes, Inst Adv Biosci, CHU Grenoble Alpes, Inserm,CNRS,Team Environm Epidemiol, Grenoble, France.
   [Alemany, Silvia] Univ Autonoma Barcelona, Vall dHebron Res Inst VHIR, Psychiat Genet Unit, Grp Psychiat Mental Hlth & Addict, Barcelona, Spain.
   [Alemany, Silvia] Hosp Univ Vall dHebron, Dept Mental Hlth, Barcelona, Spain.
   [Alemany, Silvia] Biomed Network Res Ctr Mental Hlth CIBERSAM, Inst Salud Carlos III, Madrid, Spain.
   [Plantevit, Marc] EPITA Res Lab LRE, Le Kremlin Bicetre, France.
C3 ISGlobal; Centre National de la Recherche Scientifique (CNRS); CNRS -
   Institute for Information Sciences & Technologies (INS2I); Institut
   National des Sciences Appliquees de Lyon - INSA Lyon; Universite Claude
   Bernard Lyon 1; Pompeu Fabra University; Imperial College London;
   Norwegian Institute of Public Health (NIPH); Institut National de la
   Sante et de la Recherche Medicale (Inserm); INRAE; Universite Paris
   Cite; Barcelona Institute of Science & Technology; Pompeu Fabra
   University; Centre de Regulacio Genomica (CRG); CIBER - Centro de
   Investigacion Biomedica en Red; CIBERESP; Universitat Rovira i Virgili;
   Institut d'Investigacio Sanitaria Pere Virgili (IISPV); University of
   Southern California; Imperial College London; Imperial College London;
   Vytautas Magnus University; CHU Grenoble Alpes; Centre National de la
   Recherche Scientifique (CNRS); Communaute Universite Grenoble Alpes;
   Universite Grenoble Alpes (UGA); Institut National de la Sante et de la
   Recherche Medicale (Inserm); Autonomous University of Barcelona;
   Hospital Universitari Vall d'Hebron; Vall d'Hebron Institut de Recerca
   (VHIR); Hospital Universitari Vall d'Hebron; CIBER - Centro de
   Investigacion Biomedica en Red; CIBERSAM; Instituto de Salud Carlos III
RP Maitre, L (corresponding author), ISGlobal, Barcelona, Spain.; Maitre, L (corresponding author), Univ Pompeu Fabra UPF, Barcelona, Spain.; Maitre, L (corresponding author), CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.
EM lea.maitre@isglobal.org
RI Heude, Barbara/G-3095-2016; Casas, Maribel/T-5643-2017; Vrijheid,
   Martine/H-2702-2014; Bustamante, Mariona/ABB-9142-2021; Cazabet,
   Remy/T-7028-2019; Grazuleviciene, Regina/AAR-4539-2021; Sabidó,
   Eduard/F-7914-2015; de Castro, Montserrat/ABF-8902-2020; Basagaña,
   Xavier/C-3901-2017; Stratakis, Nikos/AFV-3674-2022; Maitre,
   Léa/Y-1726-2019; Alemany, Silvia/J-7419-2013; Julvez, Jordi/R-4531-2017;
   Urquiza Ortiz, Jose Miguel/E-2446-2018; Wright, John/H-1624-2012
OI Alemany, Silvia/0000-0002-7925-6767; Stratakis, Nikolaos
   (Nikos)/0000-0003-4613-0989; Julvez, Jordi/0000-0003-0818-4003; Urquiza
   Ortiz, Jose Miguel/0000-0003-2220-607X; Guimbaud,
   Jean-Baptiste/0000-0003-3748-1453; Wright, John/0000-0001-9572-7293
FU Norwegian Ministry of Health and Care Services; Ministry of Education
   and Research; Spanish Ministry of Science and Innovation to the EMBL;
   Centro de Excelencia Severo Ochoa; CERCA Programme / Generalitat de
   Catalunya [ICTS OmicsTech]; Secretaria d'Universitats i Recerca del
   Departament d'Economia i Coneixement de la Generalitat de Catalunya
   [2021SGR01225, 2021SGR01563, H2020-EU.3.1.2, 874583]; CIFRE PhD
   fellowship [2020/1297]; Juan de la Cierva-Incorporacin fellowship
   [IJC2020-045355-I, MCIN/AEI/10.13039/501100011033]; Spanish Ministerio
   de Economa, Industria y Competitividad; Spanish Ministry of Science and
   Innovation through the "Centro de Excelencia Severo Ochoa [2019-2023,
   CEX2018-000806-S]; Generalitat de Catalunya through the CERCA Program;
   Catalan program PERIS [SLT017/20/000119]; Departament de Salut de la
   Generalitat de Catalunya (Spain) - UK Research and Innovation Future
   Leaders Fellowship [MR/S03532X/1, CP22/00026]; Instituto de Salud Carlos
   III - European Union Found: Fondo Social Europeo Plus; European
   Community;  [308333]
FX The authors would like to thank all the participating children, parents,
   practitioners, and researchers in the six countries who took part in
   this study. The Norwegian Mother, Father and Child Cohort Study is
   supported by the Norwegian Ministry of Health and Care Services and the
   Ministry of Education and Research. We also acknowledge the support of
   the Spanish Ministry of Science and Innovation to the EMBL partnership,
   the Centro de Excelencia Severo Ochoa, and the CERCA Programme /
   Generalitat de Catalunya. The CRG/UPF Proteomics Unit is part of the
   Spanish Infrastructure for Omics Technologies (ICTS OmicsTech) and it is
   supported by "Secretaria d'Universitats i Recerca del Departament
   d'Economia i Coneixement de la Generalitat de Catalunya" (2021SGR01225
   and 2021SGR01563). This project was funded by the
   H2020-EU.3.1.2.-Preventing Disease Programme under grant agreement no
   874583 (ATHLETE project). JB Guimbaud was supported by a CIFRE PhD
   fellowship (#2020/1297). Lea Maitre is funded by a Juan de la
   Cierva-Incorporacion fellowship (IJC2018-035394-I) awarded by the
   Spanish Ministerio de Economia, Industria y Competitividad. ISGlobal and
   the Exposome hub acknowledges support from the Spanish Ministry of
   Science and Innovation through the "Centro de Excelencia Severo Ochoa
   2019-2023" Program (CEX2018-000806-S), and support from the Generalitat
   de Catalunya through the CERCA Program. Jose Urquiza is supported by
   Catalan program PERIS (Ref.: SLT017/20/000119), granted by Departament
   de Salut de la Generalitat de Catalunya (Spain). Oliver Robinson was
   funded by the UK Research and Innovation Future Leaders Fellowship
   (MR/S03532X/1). Silvia Alemany holds a Miquel Servet-I contract
   (CP22/00026) awarded by the Instituto de Salud Carlos III co-funded by
   the European Union Found: Fondo Social Europeo Plus, FSE + . Monica
   Lopez-Vicente is funded by a Juan de la Cierva-Incorporacion fellowship
   (project IJC2020-045355-I, funded by MCIN/AEI/10.13039/501100011033 and
   for the European Union NextGenerationEU/PRTR). The data of the cohorts
   (BiB, EDEN, INMA, KANC, MoBa and RHEA) provided to this research leading
   to these results has received funding from the European Community's
   Seventh Framework Programme (FP7/2007-2013) under grant agreement no
   308333-the HELIX project. Fig. 2 was created with BioRender.com.
CR Achenbach T. M., 1991, Integrative guide for the 1991 CBCL 14-18, YSR, and TRF Profiles
   Agier L, 2019, LANCET PLANET HEALTH, V3, pE81, DOI 10.1016/S2542-5196(19)30010-5
   Agier L, 2016, ENVIRON HEALTH PERSP, V124, P1848, DOI 10.1289/EHP172
   [Anonymous], **DATA OBJECT**, DOI DOI 10.5281/ZENODO.10519296
   [Anonymous], 2019, RESP MED, DOI DOI 10.1016/J.RMED.2019.105813
   [Anonymous], 2011, Encyclopedia of Clinical Neuropsychology, DOI 10.1007/978-0-387-79948-3_1315.
   Balagopal P, 2011, CIRCULATION, V123, P2749, DOI 10.1161/CIR.0b013e31821c7c64
   Bergstra J, 2011, ADV NEURAL INF PROCE, V24
   Caspi A, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.3221
   Cervin M, 2021, J AM ACAD CHILD PSY, V60, P902, DOI 10.1016/j.jaac.2020.08.440
   Chatzi L, 2017, INT J EPIDEMIOL, V46, P1392, DOI 10.1093/ije/dyx084
   Chen TQ, 2016, KDD'16: PROCEEDINGS OF THE 22ND ACM SIGKDD INTERNATIONAL CONFERENCE ON KNOWLEDGE DISCOVERY AND DATA MINING, P785, DOI 10.1145/2939672.2939785
   COHEN S, 1988, CLAR SYMP, P31
   Constantinou MP, 2019, J AM ACAD CHILD PSY, V58, P776, DOI 10.1016/j.jaac.2018.11.011
   D'Agostino RB, 2008, CIRCULATION, V117, P743, DOI 10.1161/CIRCULATIONAHA.107.699579
   Dieterle F, 2006, ANAL CHEM, V78, P4281, DOI 10.1021/ac051632c
   Ding YL, 2023, METABOLITES, V13, DOI 10.3390/metabo13091017
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   Farewell CV, 2021, INFANT MENT HEALTH J, V42, P603, DOI 10.1002/imhj.21925
   Friedman J., 2001, The Elements of Statistical Learning Data Mining, Inference, and Prediction, DOI DOI 10.1007/978
   Gao P, 2021, FRONT GENET, V12, DOI 10.3389/fgene.2021.783930
   Gaye A, 2014, INT J EPIDEMIOL, V43, P1929, DOI 10.1093/ije/dyu188
   Grazuleviciene R, 2015, INT J HYG ENVIR HEAL, V218, P358, DOI 10.1016/j.ijheh.2015.02.004
   Grinsztajn L., 2022, ADV NEURAL INF PROCE, V35, P507, DOI DOI 10.48550/ARXIV.2207.08815
   Guimbaud J., B ML BASED HLTH ECRS, DOI [10.6084/m9.figshare.25625109, DOI 10.6084/M9.FIGSHARE.25625109]
   Guxens M, 2012, INT J EPIDEMIOL, V41, P930, DOI 10.1093/ije/dyr054
   Haltigan JD, 2018, J AM ACAD CHILD PSY, V57, P384, DOI 10.1016/j.jaac.2018.03.010
   Hart S., 1989, The New Palgrave: Game Theory, P210
   Hastie T., 2009, The Elements of Statistical Learning: Data Mining, Inference, and Prediction, V2, DOI DOI 10.1007/978-0-387-84858-7
   He YX, 2021, DIABETES CARE, V44, P935, DOI 10.2337/dc20-2049
   Heude B, 2016, INT J EPIDEMIOL, V45, P353, DOI 10.1093/ije/dyv151
   Jaffee Sara R, 2008, Psychiatry, V7, P496, DOI 10.1016/j.mppsy.2008.10.002
   Johns DO, 2012, ENVIRON HEALTH PERSP, V120, P1238, DOI 10.1289/ehp.1204939
   Khera AV, 2018, NAT GENET, V50, P1219, DOI 10.1038/s41588-018-0183-z
   Koppe JG, 2006, ACTA PAEDIATR, V95, P106, DOI 10.1080/08035320600886646
   Lau CHE, 2018, BMC MED, V16, DOI 10.1186/s12916-018-1190-8
   Le Magueresse-Battistoni B, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00582
   Lim J, 2018, NOISE HEALTH, V20, P199, DOI 10.4103/nah.NAH_9_18
   Lundberg SM, 2017, ADV NEUR IN, V30
   Lundberg SM, 2020, NAT MACH INTELL, V2, P56, DOI 10.1038/s42256-019-0138-9
   Lundberg SM, 2019, ARXIV
   Magnus P, 2016, INT J EPIDEMIOL, V45, P382, DOI 10.1093/ije/dyw029
   Maitre L, 2022, NAT COMMUN, V13, DOI 10.1038/s41467-022-34422-2
   Maitre L, 2021, ENVIRON INT, V153, DOI 10.1016/j.envint.2021.106523
   Maitre L, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2017-021311
   Murray GK, 2021, JAMA PSYCHIAT, V78, P210, DOI 10.1001/jamapsychiatry.2020.3042
   NEEDLEMAN HL, 1990, NEW ENGL J MED, V322, P83, DOI 10.1056/NEJM199001113220203
   Neufcourt L, 2022, ENVIRON HEALTH PERSP, V130, DOI 10.1289/EHP11015
   Novgorodtseva TP, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-82
   Padmanabhan JL, 2017, SCHIZOPHR RES, V181, P17, DOI 10.1016/j.schres.2016.10.014
   Paltiel L., 2014, Norsk Epidemiologi, V24, P29
   Park SK, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0098632
   Pries LK, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.671334
   Pryce CR, 2005, NEUROSCI BIOBEHAV R, V29, P649, DOI 10.1016/j.neubiorev.2005.03.011
   Quanjer PH, 2012, EUR RESPIR J, V40, P1324, DOI 10.1183/09031936.00080312
   Rauh VA, 2016, J CHILD PSYCHOL PSYC, V57, P775, DOI 10.1111/jcpp.12537
   Rijlaarsdam J, 2021, J PSYCHIATR RES, V140, P214, DOI 10.1016/j.jpsychires.2021.05.029
   Robinson O, 2018, ENVIRON HEALTH PERSP, V126, DOI 10.1289/EHP2862
   Rosseel Y, 2012, J STAT SOFTW, V48, P1, DOI 10.18637/jss.v048.i02
   Stekhoven DJ, 2012, BIOINFORMATICS, V28, P112, DOI 10.1093/bioinformatics/btr597
   Stratakis N, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.1007
   Sun SY, 2022, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.795044
   Sun YL, 2019, RESP RES, V20, DOI 10.1186/s12931-019-1209-5
   Tamayo-Uria I, 2019, ENVIRON INT, V123, P189, DOI 10.1016/j.envint.2018.11.067
   Tsai JP, 2017, TZU CHI MED J, V29, P192, DOI 10.4103/tcmj.tcmj_123_17
   Vassos E, 2020, PSYCHOL MED, V50, P2213, DOI 10.1017/S0033291719002319
   Vrijheid M, 2021, ENVIRON EPIDEMIOL, V5, DOI 10.1097/EE9.0000000000000166
   Vrijheid M, 2014, ENVIRON HEALTH PERSP, V122, P535, DOI 10.1289/ehp.1307204
   Wang F, 2008, OBES REV, V9, P615, DOI 10.1111/j.1467-789X.2008.00507.x
   Weihrauch-Blüher S, 2019, METABOLISM, V92, P147, DOI 10.1016/j.metabol.2018.12.001
   Wild CP, 2005, CANCER EPIDEM BIOMAR, V14, P1847, DOI 10.1158/1055-9965.EPI-05-0456
   Wilkins JT, 2021, J AM HEART ASSOC, V10, DOI 10.1161/JAHA.120.019890
   Wray NR, 2021, JAMA PSYCHIAT, V78, P101, DOI 10.1001/jamapsychiatry.2020.3049
   Wright J, 2013, INT J EPIDEMIOL, V42, P978, DOI 10.1093/ije/dys112
   Yang PY, 2010, CURR BIOINFORM, V5, P296, DOI 10.2174/157489310794072508
NR 75
TC 4
Z9 5
U1 2
U2 15
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2730-664X
J9 COMMUN MED-LONDON
JI Communications Med.
PD MAY 23
PY 2024
VL 4
IS 1
AR 98
DI 10.1038/s43856-024-00513-y
PG 14
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA RU6T4
UT WOS:001230220700002
PM 38783062
OA gold
DA 2025-06-11
ER

PT J
AU Song, IS
   Ki, EY
   Han, K
   Ryu, JJ
   Park, JB
AF Song, In-Seok
   Ki, Eun Young
   Han, Kyungdo
   Ryu, Jae-Jun
   Park, Jun-Beom
TI Evaluation of the Association between Menstrual Cycle Irregularity and
   Dental Pain or Chewing Discomfort in Women before Menopause
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE epidemiology; mastication; menstrual cycle; nutrition surveys; oral
   health; toothache
ID METABOLIC SYNDROME; NATIONAL-HEALTH; ORAL-HEALTH; OBESITY; STRESS;
   TESTOSTERONE; VALIDITY; CARIES; RISK; DHEA
AB This study was performed to assess the relationship between menstrual irregularity and dental pain or chewing discomfort in women before menopause, using nationally representative data. This study analyzed 4595 participants who were 19 years or older, and did not have missing values for outcome variables from the Korean National Health and Nutrition Examination Survey. Tooth pain was considered present if the participant felt throbbing discomfort, pain, or sensitivity when eating hot or cold food or drinking hot or cold beverages. Self-reported oral chewing discomfort was obtained. Adjusted odds ratios and their 95% confidence intervals for tooth pain in the individuals with menstrual cycle irregularity were 1.30 (1.05, 1.62) after adjustment for age, body mass index, drinking, smoking, income, exercise, stress, metabolic syndrome, and the frequency of tooth brushing. Adjusted odds ratios and their 95% confidence intervals for chewing discomfort in the individuals with menstrual cycle irregularity were 1.33 (1.03, 1.72) after adjustment. The association between menstrual irregularity and dental pain or chewing discomfort in women before menopause was provenafter adjusting for confounding factorsby multiple logistic regression analyses. Menstrual cycle irregularity may be considered a potential risk indicator for dental pain or chewing discomfort in Korean women before menopause.
C1 [Song, In-Seok] Korea Univ, Anam Hosp, Dept Oral & Maxillofacial Surg, Seoul 02841, South Korea.
   [Ki, Eun Young] Catholic Univ Korea, Coll Med, Dept Obstet & Gynecol, Seoul 06591, South Korea.
   [Han, Kyungdo] Catholic Univ Korea, Coll Med, Dept Biostat, Seoul 06591, South Korea.
   [Ryu, Jae-Jun] Korea Univ, Anam Hosp, Dept Prosthodont, Seoul 02841, South Korea.
   [Park, Jun-Beom] Catholic Univ Korea, Coll Med, Dept Periodont, Seoul 06591, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine); Catholic
   University of Korea; Catholic University of Korea; Korea University;
   Korea University Medicine (KU Medicine); Catholic University of Korea
RP Park, JB (corresponding author), Catholic Univ Korea, Coll Med, Dept Periodont, Seoul 06591, South Korea.
EM sis80@naver.com; mdkey@catholic.ac.kr; hkd917@naver.com;
   koprosth@gmail.com; jbassoonis@yahoo.co.kr
RI Park, Jun-Beom/I-8201-2019; Ryu, Jae-Jun/AAL-6362-2020; Song,
   In-Seok/T-7903-2017
OI Song, In-Seok/0000-0002-0763-8838; Park, Jun-Beom/0000-0002-8915-1555
CR Agarwal DP, 2002, ALCOHOL ALCOHOLISM, V37, P409, DOI 10.1093/alcalc/37.5.409
   Alswat Khaled, 2016, J Clin Med Res, V8, P147, DOI 10.14740/jocmr2433w
   Amarasena N, 2015, J PUBLIC HEALTH DENT, V75, P126, DOI 10.1111/jphd.12080
   BEAN JA, 1979, AM J EPIDEMIOL, V109, P181, DOI 10.1093/oxfordjournals.aje.a112673
   Cao X, 2017, J DIABETES, V9, P378, DOI 10.1111/1753-0407.12424
   Chang PJ, 2009, AUST NZ J OBSTET GYN, V49, P689, DOI 10.1111/j.1479-828X.2009.01097.x
   Chun YH, 2013, LIPIDS HEALTH DIS, V12, DOI 10.1186/1476-511X-12-84
   Cobb KL, 2003, MED SCI SPORT EXER, V35, P711, DOI 10.1249/01.MSS.0000064935.68277.E7
   Soares MEC, 2017, CLIN ORAL INVEST, V21, P159, DOI 10.1007/s00784-016-1768-5
   Dovom MR, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0168402
   Ferraz EG, 2016, ACTA ODONTOL SCAND, V74, P405, DOI 10.3109/00016357.2016.1169555
   Glueck CJ, 1998, CRANIO, V16, P143, DOI 10.1080/08869634.1998.11746052
   Han K, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000002791
   Han K, 2016, MATURITAS, V85, P73, DOI 10.1016/j.maturitas.2015.12.010
   Järvelaid M, 2005, ACTA OBSTET GYN SCAN, V84, P645, DOI 10.1111/j.0001-6349.2005.00372.x
   Jukic AMZ, 2008, AM J EPIDEMIOL, V167, P25, DOI 10.1093/aje/kwm265
   Kim YS, 2017, INT J DENT HYG, V15, P172, DOI 10.1111/idh.12207
   Kim YH, 2014, CLIN ORAL INVEST, V18, P1517, DOI 10.1007/s00784-013-1112-2
   Kollipaka R, 2013, J OBSTET GYNAECOL, V33, P489, DOI 10.3109/01443615.2013.782272
   Koreeda Nobuko, 2005, J Oral Sci, V47, P159, DOI 10.2334/josnusd.47.159
   Kyrou L, 2008, HORM-INT J ENDOCRINO, V7, P287, DOI 10.14310/horm.2002.1209
   Labrie F, 1998, STEROIDS, V63, P322, DOI 10.1016/S0039-128X(98)00007-5
   Labrie F, 2010, PROG BRAIN RES, V182, P97, DOI 10.1016/S0079-6123(10)82004-7
   Machtei EE, 2004, J PERIODONTOL, V75, P408, DOI 10.1902/jop.2004.75.3.408
   Mustaqeem M, 2015, Mymensingh Med J, V24, P161
   Nagma S, 2015, J CLIN DIAGN RES, V9, pQC01, DOI 10.7860/JCDR/2015/6906.5611
   Nascimento GG, 2016, OBES REV, V17, P587, DOI 10.1111/obr.12418
   Oh JY, 2007, KOREAN J FAM MED, V28, P532
   Özçaka Ö, 2005, J CLIN PERIODONTOL, V32, P1170, DOI 10.1111/j.1600-051X.2005.00841.x
   PEDERSEN AB, 1991, AM J CLIN NUTR, V53, P879, DOI 10.1093/ajcn/53.4.879
   Roumain J, 1998, DIABETES CARE, V21, P346, DOI 10.2337/diacare.21.3.346
   Small CM, 2007, ANN EPIDEMIOL, V17, P163, DOI 10.1016/j.annepidem.2006.05.005
   Solomon CG, 2001, JAMA-J AM MED ASSOC, V286, P2421, DOI 10.1001/jama.286.19.2421
   Van Anders SM, 2006, AM J HUM BIOL, V18, P841, DOI 10.1002/ajhb.20555
   Wei SY, 2009, OBESITY, V17, P1070, DOI 10.1038/oby.2008.641
   Young EA, 2000, ARCH GEN PSYCHIAT, V57, P1157, DOI 10.1001/archpsyc.57.12.1157
NR 36
TC 3
Z9 3
U1 1
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD APR
PY 2019
VL 8
IS 4
AR 454
DI 10.3390/jcm8040454
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HX6FT
UT WOS:000467500200039
PM 30987369
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Marek, G
   Pannu, V
   Shanmugham, P
   Pancione, B
   Mascia, D
   Crosson, S
   Ishimoto, T
   Sautin, YY
AF Marek, George
   Pannu, Varinderpal
   Shanmugham, Prashanth
   Pancione, Brianna
   Mascia, Dominic
   Crosson, Sean
   Ishimoto, Takuji
   Sautin, Yuri Y.
TI Adiponectin Resistance and Proinflammatory Changes in the Visceral
   Adipose Tissue Induced by Fructose Consumption via
   Ketohexokinase-Dependent Pathway
SO DIABETES
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; ACTIVATED PROTEIN-KINASE; METABOLIC
   SYNDROME; INSULIN-RESISTANCE; DIETARY FRUCTOSE; URIC-ACID; OBESITY;
   GLUCOSE; INFLAMMATION; BEVERAGES
AB An epidemic of obesity and type 2 diabetes is linked with the increase in consumption of fructose-containing sugars, such as sucrose and high-fructose corn syrup. In mammalian cells, fructose is metabolized predominantly via phosphorylation to fructose-1 phosphate by ketohexokinase (KHK) or by alternative pathways. Here we demonstrate that a KHK-dependent pathway mediates insulin resistance and inflammatory changes in the visceral fat in response to high fructose. We used mice (males, C57BL/6 background) including littermate wildtype control and mice lacking both isoforms of KHK (KHK-null). Fructose diet induced metabolic syndrome, including visceral obesity, insulin resistance, proinflammatory changes in the visceral fat (production of proinflammatory adipokines and macrophage infiltration), the endoplasmic reticulum stress signaling, and decrease of the high-molecular weight adiponectin followed by decrease in the downstream signaling. KHK-KO mice consuming the same high-fructose diet remained lean, with normal insulin sensitivity and healthy visceral adipose tissue with normal adiponectin function not distinguishable from the control by any of the tested parameters. This study demonstrates that blocking KHK and redirecting fructose metabolism to alternative pathways is an effective way to prevent visceral obesity and insulin resistance induced by high fructose, a widespread component of Western diets.
C1 [Marek, George; Pannu, Varinderpal; Shanmugham, Prashanth; Pancione, Brianna; Mascia, Dominic; Crosson, Sean; Sautin, Yuri Y.] Univ Florida, Dept Med, Gainesville, FL 32611 USA.
   [Ishimoto, Takuji] Univ Colorado, Dept Med, Denver, CO USA.
C3 State University System of Florida; University of Florida; University of
   Colorado System; University of Colorado Denver; University of Colorado
   Anschutz Medical Campus
RP Sautin, YY (corresponding author), Univ Florida, Dept Med, Gainesville, FL 32611 USA.
EM yuri.sautin@medicine.ufl.edu
RI Ishimoto, Takuji/M-4873-2014
OI Ishimoto, Takuji/0000-0002-9861-5331; Sautin, Yuri/0000-0003-3618-5134
FU American Diabetes Association [7-12-BS-162]; Gatorade Funds
FX This work was supported by the American Diabetes Association grant
   7-12-BS-162 (to Y.Y.S.) and by Gatorade Funds.
CR Baldwin W, 2011, DIABETES, V60, P1258, DOI 10.2337/db10-0916
   Bray GA, 2004, AM J CLIN NUTR, V79, P537
   Cirillo P, 2009, J AM SOC NEPHROL, V20, P545, DOI 10.1681/ASN.2008060576
   Diggle CP, 2010, PHYSIOL GENOMICS, V42A, P235, DOI 10.1152/physiolgenomics.00128.2010
   Diggle CP, 2009, J HISTOCHEM CYTOCHEM, V57, P763, DOI 10.1369/jhc.2009.953190
   FROESCH ER, 1962, J BIOL CHEM, V237, P3317
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Glimcher LH, 2010, ANN RHEUM DIS, V69, P67, DOI 10.1136/ard.2009.119388
   Havel PJ, 2005, NUTR REV, V63, P133, DOI [10.1301/nr.2005.may.133-157, 10.1111/j.1753-4887.2005.tb00132.x]
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   Ishimoto T, 2013, HEPATOLOGY, V58, P1632, DOI 10.1002/hep.26594
   Ishimoto T, 2012, P NATL ACAD SCI USA, V109, P4320, DOI 10.1073/pnas.1119908109
   Johnson RJ, 2013, DIABETES, V62, P3307, DOI 10.2337/db12-1814
   Johnson RJ, 2009, ENDOCR REV, V30, P96, DOI 10.1210/er.2008-0033
   Jürgens H, 2005, OBES RES, V13, P1146, DOI 10.1038/oby.2005.136
   Kadowaki T, 2005, ENDOCR REV, V26, P439, DOI 10.1210/er.2005-0005
   Kaufman RJ, 2010, EMBO MOL MED, V2, P189, DOI 10.1002/emmm.201000076
   Lanaspa M.A., 2014, J AM SOC NEPHROL
   Lanaspa MA, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3434
   Lee AH, 2008, SCIENCE, V320, P1492, DOI 10.1126/science.1158042
   Lim JS, 2010, NAT REV GASTRO HEPAT, V7, P251, DOI 10.1038/nrgastro.2010.41
   MAENPAA PH, 1968, SCIENCE, V161, P1253, DOI 10.1126/science.161.3847.1253
   MASSON S, 1994, BBA-GEN SUBJECTS, V1199, P166, DOI 10.1016/0304-4165(94)90112-0
   Matsuzawa Y, 2005, ATHEROSCLEROSIS SUPP, V6, P7, DOI 10.1016/j.atherosclerosissup.2005.02.003
   MAYES PA, 1993, AM J CLIN NUTR, V58, P754
   Nagai Y, 2002, AM J PHYSIOL-ENDOC M, V282, pE1180, DOI 10.1152/ajpendo.00471.2001
   Ouyang X, 2008, J HEPATOL, V48, P993, DOI 10.1016/j.jhep.2008.02.011
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Samuel VT, 2012, CELL, V148, P852, DOI 10.1016/j.cell.2012.02.017
   Sautin YY, 2005, MOL CELL BIOL, V25, P575, DOI 10.1128/MCB.25.2.575-589.2005
   Stanhope KL, 2008, CURR OPIN LIPIDOL, V19, P16, DOI 10.1097/MOL.0b013e3282f2b24a
   Stanhope KL, 2013, CURR OPIN LIPIDOL, V24, P198, DOI 10.1097/MOL.0b013e3283613bca
   Stanhope KL, 2009, J CLIN INVEST, V119, P1322, DOI 10.1172/JCI37385
   Tomas E, 2002, P NATL ACAD SCI USA, V99, P16309, DOI 10.1073/pnas.222657499
   Tsuchida A, 2004, J BIOL CHEM, V279, P30817, DOI 10.1074/jbc.M402367200
   Turer AT, 2012, DIABETOLOGIA, V55, P2319, DOI 10.1007/s00125-012-2598-x
   Van den Berghe G, 1986, Prog Biochem Pharmacol, V21, P1
   Waki H, 2003, J BIOL CHEM, V278, P40352, DOI 10.1074/jbc.M300365200
   Wang ZV, 2007, MOL CELL BIOL, V27, P3716, DOI 10.1128/MCB.00931-06
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Wellen KE, 2003, J CLIN INVEST, V112, P1785, DOI 10.1172/JCI20514
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yamauchi T, 2002, NAT MED, V8, P1288, DOI 10.1038/nm788
   Yamauchi T, 2013, CELL METAB, V17, P185, DOI 10.1016/j.cmet.2013.01.001
NR 46
TC 43
Z9 46
U1 0
U2 21
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD FEB
PY 2015
VL 64
IS 2
BP 508
EP 518
DI 10.2337/db14-0411
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CA3ST
UT WOS:000348827100021
PM 25187370
OA Bronze
DA 2025-06-11
ER

PT J
AU Geiker, NRW
   Astrup, A
   Hjorth, MF
   Sjödin, A
   Pijls, L
   Markus, CR
AF Geiker, N. R. W.
   Astrup, A.
   Hjorth, M. F.
   Sjodin, A.
   Pijls, L.
   Markus, C. Rob
TI Does stress influence sleep patterns, food intake, weight gain,
   abdominal obesity and weight loss interventions and vice versa?
SO OBESITY REVIEWS
LA English
DT Review
DE Cortisol; cravings; sleep; visceral obesity
ID PITUITARY-ADRENAL AXIS; TERM CORTISOL-LEVELS; BODY-MASS INDEX; LIFE
   EVENTS; PSYCHOSOCIAL STRESS; COGNITIVE PERFORMANCE; WAIST CIRCUMFERENCE;
   METABOLIC SYNDROME; 5-HTTLPR GENOTYPE; CIRCADIAN-RHYTHM
AB Decades of research have reported only weak associations between the intakes of specific foods or drinks and weight gain and obesity. Randomized controlled dietary intervention trials have only shown very modest effects of changes in nutrient intake and diet composition on body weight in obese subjects. This review summarizes the scientific evidence on the role mental stress (either in or not in association with impaired sleep) may play in poor sleep, enhanced appetite, cravings and decreased motivation for physical activity. All these factors contribute to weight gain and obesity, possibly via decreasing the efficacy of weight loss interventions. We also review evidence for the role that lifestyle and stress management may play in achieving weight loss in stress-vulnerable individuals with overweight.
C1 [Geiker, N. R. W.] Copenhagen Univ Hosp Herlev & Gentofte, Clin Nutr Res Unit, Kildegardsvej 28, DK-2900 Hellerup, Denmark.
   [Astrup, A.; Hjorth, M. F.; Sjodin, A.] Univ Copenhagen, Fac Sci, Dept Nutr Exercise & Sports, Copenhagen, Denmark.
   [Pijls, L.] Loekintofood Gcv Scs, Brussels, Belgium.
   [Markus, C. Rob] Maastricht Univ, Fac Psychol & Neurosci, Neuropsychol & Psychopharmacol, Maastricht, Netherlands.
C3 University of Copenhagen; Maastricht University
RP Geiker, NRW (corresponding author), Copenhagen Univ Hosp Herlev & Gentofte, Clin Nutr Res Unit, Kildegardsvej 28, DK-2900 Hellerup, Denmark.
EM nina.rica.wium.geiker@regionh.dk
RI Geiker, Nina/GLR-2718-2022; Hjorth, Mads/A-1760-2015; Astrup,
   Arne/HZL-1679-2023; Sjödin, Anders/B-6975-2015
OI Geiker, Nina Rica Wium/0000-0001-8063-5820
CR Adam TC, 2007, PHYSIOL BEHAV, V91, P449, DOI 10.1016/j.physbeh.2007.04.011
   Åkerstedt T, 2012, SLEEP MED, V13, P674, DOI 10.1016/j.sleep.2011.12.013
   [Anonymous], 2013, WORKPL STRESS RIS 83
   Anton SD, 2008, EAT WEIGHT DISORD-ST, V13, P30
   Aschbacher K, 2014, PSYCHONEUROENDOCRINO, V46, P14, DOI 10.1016/j.psyneuen.2014.04.003
   Barclay NL, 2011, SLEEP MED, V12, P403, DOI 10.1016/j.sleep.2010.09.009
   BAUM A, 1990, HEALTH PSYCHOL, V9, P653, DOI 10.1037/0278-6133.9.6.653
   Bin YS, 2013, AM J EPIDEMIOL, V177, P826, DOI 10.1093/aje/kws308
   Bin YS, 2012, SLEEP MED REV, V16, P223, DOI 10.1016/j.smrv.2011.07.003
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   Bjorntorp P, 1996, INT J OBESITY, V20, P291
   Block JP, 2009, AM J EPIDEMIOL, V170, P181, DOI 10.1093/aje/kwp104
   Bodnar LM, 2005, BIOL PSYCHIAT, V58, P679, DOI 10.1016/j.biopsych.2005.05.009
   Bonke J, 2015, SLEEP MED, V16, P385, DOI 10.1016/j.sleep.2014.10.021
   Born JM, 2010, INT J OBESITY, V34, P172, DOI 10.1038/ijo.2009.221
   Born JM, 2012, PHYSIOL BEHAV, V105, P321, DOI 10.1016/j.physbeh.2011.08.015
   Bosy-Westphal A, 2008, OBESITY FACTS, V1, P266, DOI 10.1159/000158874
   Brondel L, 2010, AM J CLIN NUTR, V91, P1550, DOI 10.3945/ajcn.2009.28523
   Broussard JL, 2016, OBESITY, V24, P132, DOI 10.1002/oby.21321
   Buckley TM, 2005, J CLIN ENDOCR METAB, V90, P3106, DOI 10.1210/jc.2004-1056
   Calkins AW, 2013, BEHAV SLEEP MED, V11, P133, DOI 10.1080/15402002.2011.643968
   Calvin AD, 2013, CHEST, V144, P79, DOI 10.1378/chest.12-2829
   Capello AEM, 2014, PSYCHONEUROENDOCRINO, V45, P96, DOI 10.1016/j.psyneuen.2014.03.005
   Cappuccio FP, 2008, SLEEP, V31, P619, DOI 10.1093/sleep/31.5.619
   Cerit H, 2013, PSYCHONEUROENDOCRINO, V38, P201, DOI 10.1016/j.psyneuen.2012.05.016
   Chahal H, 2013, PEDIATR OBES, V8, P42, DOI 10.1111/j.2047-6310.2012.00085.x
   Chaput JP, 2012, INT J OBESITY, V36, P752, DOI 10.1038/ijo.2011.110
   Chaput J-P., 2011, SLEEP MED, V12, pS13, DOI [10.1016/S1389-9457(11)70046-6, DOI 10.1016/S1389-9457(11)70046-6]
   Chaput JP, 2008, PSYCHOSOM MED, V70, P797, DOI 10.1097/PSY.0b013e31818426fa
   Chaput JP, 2008, SLEEP, V31, P517, DOI 10.1093/sleep/31.4.517
   Chaput JP, 2007, INT J PEDIATR OBES, V2, P188, DOI 10.1080/17477160701306144
   Chaput JP, 2007, PHYSIOL BEHAV, V90, P66, DOI 10.1016/j.physbeh.2006.08.030
   Chaput JP, 2012, OBESITY FACTS, V5, P561, DOI 10.1159/000342054
   Charles Luenda E, 2011, Int J Emerg Ment Health, V13, P229
   Christaki E, 2013, J HUM NUTR DIET, V26, P132, DOI 10.1111/jhn.12086
   Chrousos GP, 2009, NAT REV ENDOCRINOL, V5, P374, DOI 10.1038/nrendo.2009.106
   Cizza G, 2010, CLIN TRIALS, V7, P274, DOI 10.1177/1740774510368298
   Cota D, 2006, BRAIN RES REV, V51, P85, DOI 10.1016/j.brainresrev.2005.10.004
   Cox TL, 2013, HEALTH EDUC BEHAV, V40, P78, DOI 10.1177/1090198112439411
   Djurhuus CB, 2004, AM J PHYSIOL-ENDOC M, V286, pE488, DOI 10.1152/ajpendo.00199.2003
   Elder CR, 2012, INT J OBESITY, V36, P86, DOI 10.1038/ijo.2011.60
   Epel E, 2001, PSYCHONEUROENDOCRINO, V26, P37, DOI 10.1016/S0306-4530(00)00035-4
   Filiatrault ML, 2014, NUTR DIABETES, V4, DOI 10.1038/nutd.2014.37
   Folstein M, 2007, AM J PSYCHIAT, V164, P861, DOI 10.1176/appi.ajp.164.6.861
   Ford ES, 2014, JAMA-J AM MED ASSOC, V312, P1151, DOI 10.1001/jama.2014.8362
   Fowler-Brown AG, 2009, OBESITY, V17, P2106, DOI 10.1038/oby.2009.130
   Freedman DS, 2015, AM J CLIN NUTR, V101, P425, DOI 10.3945/ajcn.114.094672
   Gibson EL, 2006, PHYSIOL BEHAV, V89, P53, DOI 10.1016/j.physbeh.2006.01.024
   Godfrey G, 1971, J R Coll Gen Pract, V21, P276
   Gonnissen HKJ, 2013, PHYSIOL BEHAV, V121, P112, DOI 10.1016/j.physbeh.2013.04.007
   Gonnissen HKJ, 2013, BRIT J NUTR, V109, P748, DOI 10.1017/S0007114512001894
   Grosso G, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0096905
   Guyon A, 2014, J CLIN ENDOCR METAB, V99, P2861, DOI 10.1210/jc.2013-4254
   Harding JL, 2014, OBESITY, V22, P277, DOI 10.1002/oby.20423
   Harris I., 2001, ATTITUDES AM WORKPLA
   Hart CN, 2013, PEDIATRICS, V132, pE1473, DOI 10.1542/peds.2013-1274
   Himmelstein MS, 2015, OBESITY, V23, P368, DOI 10.1002/oby.20959
   Hjorth MF, 2014, INT J OBESITY, V38, P959, DOI 10.1038/ijo.2013.229
   Hjorth MF, 2016, APPL PHYSIOL NUTR ME, V41, P33, DOI 10.1139/apnm-2015-0319
   Iftikhar IH, 2015, ANN AM THORAC SOC, V12, P1364, DOI 10.1513/AnnalsATS.201504-190OC
   Jackson ML, 2014, ARCH WOMEN MENT HLTH, V17, P189, DOI 10.1007/s00737-014-0417-8
   Jackson SE, 2017, OBESITY, V25, P539, DOI 10.1002/oby.21733
   Kennedy DO, 2010, PSYCHOPHARMACOLOGY, V211, P55, DOI 10.1007/s00213-010-1870-3
   Keyes KM, 2015, PEDIATRICS, V135, P460, DOI 10.1542/peds.2014-2707
   Kim KHC, 2009, HEALTH PSYCHOL, V28, P131, DOI 10.1037/a0012648
   Kjeldsen JS, 2014, INT J OBESITY, V38, P32, DOI 10.1038/ijo.2013.147
   Klingenberg L, 2012, AM J CLIN NUTR, V96, P240, DOI 10.3945/ajcn.112.038638
   Komlos J, 2010, AM J HUM BIOL, V22, P631, DOI 10.1002/ajhb.21055
   Kyrou I, 2009, CURR OPIN PHARMACOL, V9, P787, DOI 10.1016/j.coph.2009.08.007
   Lemmens SG, 2011, PHYSIOL BEHAV, V103, P157, DOI 10.1016/j.physbeh.2011.01.009
   Lim So Young, 2016, Clin Nutr Res, V5, P143, DOI 10.7762/cnr.2016.5.3.143
   Lissner L, 2008, EUR J NUTR, V47, P424, DOI 10.1007/s00394-008-0744-5
   Long SJ, 2013, PSYCHOSOM MED, V75, P144, DOI 10.1097/PSY.0b013e31827d5fbd
   Lupien SJ, 2009, NAT REV NEUROSCI, V10, P434, DOI 10.1038/nrn2639
   Manenschijn L, 2013, J CLIN ENDOCR METAB, V98, P2078, DOI 10.1210/jc.2012-3663
   Manenschijn L, 2011, J CLIN ENDOCR METAB, V96, pE1862, DOI 10.1210/jc.2011-1551
   Markus CR, 2015, STRESS, V18, P149, DOI 10.3109/10253890.2014.990880
   Markus CR, 2013, PSYCHIAT GENET, V23, P108, DOI 10.1097/YPG.0b013e32835fe3e1
   Markus CR, 2012, J NUTR BIOCHEM, V23, P410, DOI 10.1016/j.jnutbio.2011.01.005
   Markus CR, 2011, NEUROPSYCHOPHARMACOL, V36, P819, DOI 10.1038/npp.2010.221
   Markus CR, 2008, NEUROMOL MED, V10, P247, DOI 10.1007/s12017-008-8039-9
   Markus CR, 1999, BRIT J NUTR, V82, P457, DOI 10.1017/S0007114599001713
   Markus CR, 1998, APPETITE, V31, P49, DOI 10.1006/appe.1997.0155
   Matricciani L, 2012, SLEEP MED REV, V16, P203, DOI 10.1016/j.smrv.2011.03.005
   Matricciani LA, 2012, PEDIATRICS, V129, P548, DOI 10.1542/peds.2011-2039
   Matthiessen J, 2014, SCAND J PUBLIC HEALT, V42, P385, DOI 10.1177/1403494813520356
   McNeil J, 2013, EUR J CLIN NUTR, V67, P1328, DOI 10.1038/ejcn.2013.204
   Mezick EJ, 2009, PSYCHONEUROENDOCRINO, V34, P1346, DOI 10.1016/j.psyneuen.2009.04.005
   Michaud I, 2015, OBESITY, V23, P815, DOI 10.1002/oby.21026
   Mishra GD, 2009, PUBLIC HEALTH NUTR, V12, P166, DOI 10.1017/S1368980008002413
   Morgen CS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0069860
   Nedeltcheva AV, 2009, AM J CLIN NUTR, V89, P126, DOI 10.3945/ajcn.2008.26574
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Noppe G, 2016, INT J OBES LOND
   Noreen EE, 2010, J INT SOC SPORT NUTR, V7, DOI 10.1186/1550-2783-7-31
   Oliver G, 2000, PSYCHOSOM MED, V62, P853, DOI 10.1097/00006842-200011000-00016
   Olson R, 2016, J OCCUP ENVIRON MED, V58, P314, DOI 10.1097/JOM.0000000000000650
   Olstad DL, 2016, STRESS, V19, P158, DOI 10.3109/10253890.2016.1160282
   Owen C, 2008, CURR OPIN PSYCHIATR, V21, P19, DOI 10.1097/YCO.0b013e3282f29841
   Perusse-Lachance E, 2013, ISRN NUTR, V2013
   Rivenes AC, 2009, J PSYCHOSOM RES, V66, P269, DOI 10.1016/j.jpsychores.2008.07.012
   Robinson WR, 2013, INT J OBESITY, V37, P1129, DOI 10.1038/ijo.2012.198
   Rodenbeck A, 2002, NEUROSCI LETT, V324, P159, DOI 10.1016/S0304-3940(02)00192-1
   Rosmond P, 2000, METABOLISM, V49, P1197, DOI 10.1053/meta.2000.7712
   Rutters F, 2009, OBESITY, V17, P72, DOI 10.1038/oby.2008.493
   Rutters F, 2015, STRESS, V18, P507, DOI 10.3109/10253890.2015.1064891
   Ryu SY, 2011, J KOREAN MED SCI, V26, P1124, DOI 10.3346/jkms.2011.26.9.1124
   Sandeep TC, 2005, DIABETES, V54, P872, DOI 10.2337/diabetes.54.3.872
   Schommer NC, 2003, PSYCHOSOM MED, V65, P450, DOI 10.1097/01.PSY.0000035721.12441.17
   Sims Regina, 2008, Eat Behav, V9, P137, DOI 10.1016/j.eatbeh.2007.06.006
   Sinha R, 2013, BIOL PSYCHIAT, V73, P827, DOI 10.1016/j.biopsych.2013.01.032
   Spiegel K, 2004, ANN INTERN MED, V141, P846, DOI 10.7326/0003-4819-141-11-200412070-00008
   St-Onge MP, 2014, INT J OBESITY, V38, P411, DOI 10.1038/ijo.2013.114
   St-Onge MP, 2012, AM J CLIN NUTR, V95, P818, DOI 10.3945/ajcn.111.027383
   Steiger A, 2002, SLEEP MED REV, V6, P125, DOI 10.1053/smrv.2001.0159
   Stough C, 2011, HUM PSYCHOPHARM CLIN, V26, P470, DOI 10.1002/hup.1229
   Tepper S, 2016, NUTRIENTS, V8, DOI 10.3390/nu8060366
   Thomson CA, 2012, OBESITY, V20, P1419, DOI 10.1038/oby.2012.62
   Tucker LA, 2010, AM J HEALTH PROMOT, V25, P30, DOI 10.4278/ajhp.090122-QUAN-22
   Ulrich-Lai YM, 2015, STRESS, V18, P381, DOI 10.3109/10253890.2015.1062981
   Vahtera J, 2007, SLEEP, V30, P1537, DOI 10.1093/sleep/30.11.1537
   Van Cauter E., 2005, MEDSCAPE NEUROL NEUR, V7
   van Praag HM, 2004, PROG NEURO-PSYCHOPH, V28, P891, DOI [10.1016/j.pnpbp.2004.05.031, 10.1080/15622970510030018]
   van Rossum EFC, 2006, BIOL PSYCHIAT, V59, P681, DOI 10.1016/j.biopsych.2006.02.007
   Vanaelst B, 2014, INT J BEHAV MED, V21, P292, DOI 10.1007/s12529-013-9294-1
   Walch OJ, 2016, SCI ADV, V2, DOI 10.1126/sciadv.1501705
   Wardle J, 2011, OBESITY, V19, P771, DOI 10.1038/oby.2010.241
   Westerterp-Plantenga MS, 2016, P NUTR SOC, V75, P431, DOI 10.1017/S0029665116000227
   Wiegner L, 2015, BMC FAM PRACT, V16, DOI 10.1186/s12875-015-0252-7
   Zheng H, 2009, INT J OBESITY, V33, pS8, DOI 10.1038/ijo.2009.65
NR 130
TC 170
Z9 184
U1 1
U2 56
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD JAN
PY 2018
VL 19
IS 1
BP 81
EP 97
DI 10.1111/obr.12603
PG 17
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA FO8HO
UT WOS:000417126400007
PM 28849612
DA 2025-06-11
ER

PT J
AU Hamer, M
   Boutcher, YN
   Boutcher, SH
AF Hamer, Mark
   Boutcher, Yati N.
   Boutcher, Stephen H.
TI Fatness is related to blunted vascular stress responsivity, independent
   of cardiorespiratory fitness in normal and overweight men
SO INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
LA English
DT Article
DE psychosocial stress; vascular function; cardiovascular risk;
   cardiorespiratory fitness; obesity
ID SYMPATHETIC-NERVE ACTIVITY; CORONARY-HEART-DISEASE; BODY-MASS INDEX;
   PHYSICAL-ACTIVITY; CARDIOVASCULAR-DISEASE; FAT DISTRIBUTION; AEROBIC
   FITNESS; ARTERIAL STIFFNESS; METABOLIC SYNDROME; BLOOD-PRESSURE
AB Obesity is associated with disturbed cardiovascular responsivity to mental stress, which may mediate psychosocial disease pathways. Whether being aerobically fit is protective against psychophysiological dysfunction in the presence of overweight or obesity is undetermined. Peripheral blood flow, blood pressure, and cardiac responses were measured during a 2-min mental stress task in 48 healthy men (aged 18-32 years). Mental stress-evoked increases in mean arterial pressure and heart rate, forearm vasodilatation, and cardiac parasympathetic withdrawal. Multiple linear regression analyses adjusted for age, peak oxygen uptake, and baseline forearm vascular resistance, revealed that greater fatness was related to a blunted vasodilatation response to mental stress (beta = -.31, p <.05). There were no interactive effects of fitness and fatness. Fitness does not appear to moderate the association between fatness and impaired vascular stress responsivity in normal and overweight men. (c) 2006 Elsevier B.V. All rights reserved.
C1 UCL, Dept Epidemiol & Publ Hlth, Psychobiol Grp, London WC1E 6BT, England.
   Univ New S Wales, Fac Med, Sch Med Sci, Sydney, NSW, Australia.
C3 University of London; University College London; University of New South
   Wales Sydney
RP Hamer, M (corresponding author), UCL, Dept Epidemiol & Publ Hlth, Psychobiol Grp, 1-19 Torrington Pl, London WC1E 6BT, England.
EM m.hamer@ucl.ac.uk
RI Hamer, Mark/C-1602-2008
OI Hamer, Mark/0000-0002-8726-7992
CR Agapitov AV, 2002, J HYPERTENS, V20, P1401, DOI 10.1097/00004872-200207000-00027
   Alvarez GE, 2002, CIRCULATION, V106, P2533, DOI 10.1161/01.CIR.0000041244.79165.25
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   Blair SN, 2004, JAMA-J AM MED ASSOC, V292, P1232, DOI 10.1001/jama.292.10.1232
   Boreham C, 2001, MED SCI SPORT EXER, V33, P270
   Boutcher SH, 1998, PSYCHOPHYSIOLOGY, V35, P16, DOI 10.1111/1469-8986.3510016
   Cartwright M, 2003, HEALTH PSYCHOL, V22, P362, DOI 10.1037/0278-6133.22.4.362
   Christou DD, 2005, CIRCULATION, V111, P1904, DOI 10.1161/01.CIR.0000161818.28974.1A
   CLAYTOR RP, 1991, MED SCI SPORT EXER, V23, P873
   CREWS DJ, 1987, MED SCI SPORT EXER, V19, pS114
   Davis MC, 1999, HEALTH PSYCHOL, V18, P625, DOI 10.1037/0278-6133.18.6.625
   de Simone G, 2005, AM J CLIN NUTR, V81, P757, DOI 10.1093/ajcn/81.4.757
   DEGEUS EJC, 1993, WORK STRESS, V7, P141, DOI 10.1080/02678379308257057
   Dishman RK, 2003, PSYCHOPHYSIOLOGY, V40, P370, DOI 10.1111/1469-8986.00040
   DURNIN JVGA, 1974, BRIT J NUTR, V32, P77, DOI 10.1079/BJN19740060
   Ferreira I, 2004, J HYPERTENS, V22, P145, DOI 10.1097/00004872-200401000-00024
   Grassi G, 2006, J HYPERTENS, V24, P47, DOI 10.1097/01.hjh.0000198040.47128.4c
   Hu FB, 2004, NEW ENGL J MED, V351, P2694, DOI 10.1056/NEJMoa042135
   Jackson EM, 2006, PSYCHOPHYSIOLOGY, V43, P57, DOI 10.1111/j.1469-8986.2006.00373.x
   JERN S, 1992, HYPERTENSION, V19, P520, DOI 10.1161/01.HYP.19.6.520
   Kamarck TW, 2003, PSYCHOPHYSIOLOGY, V40, P675, DOI 10.1111/1469-8986.00069
   Katzmarzyk PT, 2005, DIABETES CARE, V28, P391, DOI 10.2337/diacare.28.2.391
   Landmesser U, 2004, CIRCULATION, V109, P27, DOI 10.1161/01.CIR.0000129501.88485.1f
   Li TY, 2006, CIRCULATION, V113, P499, DOI 10.1161/CIRCULATIONAHA.105.574087
   Manson JE, 2004, ARCH INTERN MED, V164, P249, DOI 10.1001/archinte.164.3.249
   Manson JE, 2002, NEW ENGL J MED, V347, P716, DOI 10.1056/NEJMoa021067
   MARKS GC, 1989, AM J EPIDEMIOL, V130, P578, DOI 10.1093/oxfordjournals.aje.a115372
   Poirier P, 2006, CIRCULATION, V113, P898, DOI 10.1161/CIRCULATIONAHA.106.171016
   Porges S.W., 1986, Cardiorespiratory and cardiosomatic psychophysiology, P101
   RAISON JM, 1988, J HYPERTENS, V6, P299
   Ribeiro MM, 2005, CIRCULATION, V111, P1915, DOI 10.1161/01.CIR.0000161959.04675.5A
   Ribeiro MM, 2001, BRAZ J MED BIOL RES, V34, P475, DOI 10.1590/S0100-879X2001000400006
   ROBERTS DH, 1986, CLIN SCI, V70, P635, DOI 10.1042/cs0700635
   SOTHMANN MS, 1991, MED SCI SPORT EXER, V23, P860
   Steinberg HO, 1996, J CLIN INVEST, V97, P2601, DOI 10.1172/JCI118709
   Steptoe A, 2005, INT J OBESITY, V29, P1329, DOI 10.1038/sj.ijo.0803011
   Stevens J, 2002, AM J EPIDEMIOL, V156, P832, DOI 10.1093/aje/kwf114
   STUBBE JH, IN PRESS PREV MED
   Sung BH, 1997, HYPERTENSION, V30, P848, DOI 10.1161/01.HYP.30.4.848
   Sutton-Tyrrell K, 2005, CIRCULATION, V111, P3384, DOI 10.1161/CIRCULATIONAHA.104.483628
   Treiber FA, 2003, PSYCHOSOM MED, V65, P46, DOI 10.1097/00006842-200301000-00007
   Wei M, 1999, JAMA-J AM MED ASSOC, V282, P1547, DOI 10.1001/jama.282.16.1547
   Weinstein AR, 2004, JAMA-J AM MED ASSOC, V292, P1188, DOI 10.1001/jama.292.10.1188
   Wessel TR, 2004, JAMA-J AM MED ASSOC, V292, P1179, DOI 10.1001/jama.292.10.1179
   WHITNEY RJ, 1953, J PHYSIOL-LONDON, V121, P1
   Wildman RP, 2005, HYPERTENSION, V45, P187, DOI 10.1161/01.HYP.0000152200.10578.5d
NR 46
TC 18
Z9 18
U1 0
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0167-8760
EI 1872-7697
J9 INT J PSYCHOPHYSIOL
JI Int. J. Psychophysiol.
PD MAR
PY 2007
VL 63
IS 3
BP 251
EP 257
DI 10.1016/j.ijpsycho.2006.11.002
PG 7
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
   Psychology, Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Neurosciences & Neurology; Physiology
GA 149SP
UT WOS:000245167200004
PM 17196278
DA 2025-06-11
ER

PT J
AU Heyman, A
   Lavalle, JB
   Hawkins, EB
   Edwards, L
AF Heyman, Andrew
   Lavalle, James B.
   Hawkins, Ernest B.
   Edwards, Lena
TI An integrative medicine approach to managing nutrient depletions in the
   cardiometabolic patient
SO JOURNAL OF MENS HEALTH
LA English
DT Article
DE Cardiometabolic disease; Nutritient depletion
ID TYPE-2 DIABETES-MELLITUS; VITAMIN-D DEFICIENCY; COENZYME Q(10); SERUM
   25-HYDROXYVITAMIN-D; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; DIETARY
   MAGNESIUM; MYOCARDIAL-INFARCTION; INSULIN-RESISTANCE; CLINICAL MEDICINE
AB This article presents a further exploration of the risk factors underlying cardiometabolic (CM) disease and their identification and management within an integrative medicine framework as illustrated by the case of a 30-year-old obese African American male who presented for a follow-up visit with regard to his metabolic syndrome (MeS)
   This article reviews in detail the pathophysiology of common nutrient depletions and their contribution to CM disease risk as well as drug-induced nutrient depletions incurred curing treatment for CM disease and the MeS The review also includes a detailed discussion on the evaluation and treatment of nutrient deficiencies
   The article concludes with a detailed discussion of the case resolution Following an extensive metabolic evaluation a program of specific nutrient repletion was instituted alongside testosterone replacement therapy in addition to instituting stress reduction techniques and herbal supplements to improve his physiologic stress response The patient returned to clinic after 3 months to review progress and laboratory results He had lost 15 pounds reported increased energy levels and complete elimination of joint aches He was scheduled to return to the clinic after a further 3 months for re-evaluation (C) 2010 WPMH GmbH Published by Elsevier Ireland Ltd
C1 [Heyman, Andrew] Univ Michigan, Sch Med, Dept Family Med, Ann Arbor, MI 48109 USA.
   [Lavalle, James B.] Univ Cincinnati, Coll Pharm, Cincinnati, OH 45267 USA.
   [Hawkins, Ernest B.] Integrat Hlth Resources, Asheville, NC USA.
   [Edwards, Lena] Balance Hlth & Wellness Ctr, Lexington, KY USA.
C3 University of Michigan System; University of Michigan; University System
   of Ohio; University of Cincinnati
RP Heyman, A (corresponding author), Univ Michigan, Sch Med, Dept Family Med, Ann Arbor, MI 48109 USA.
CR Alaimo K, 1994, Adv Data, P1
   ALTURA B M, 1985, Magnesium, V4, P226
   ANDERSON RA, 1992, BIOL TRACE ELEM RES, V32, P117, DOI 10.1007/BF02784595
   Balk EM, 2007, DIABETES CARE, V30, P2154, DOI 10.2337/dc06-0996
   Bo S, 2006, AM J CLIN NUTR, V84, P1062, DOI 10.1093/ajcn/84.5.1062
   Caso G, 2007, AM J CARDIOL, V99, P1409, DOI 10.1016/j.amjcard.2006.12.063
   CHROUSOS GP, 1992, JAMA-J AM MED ASSOC, V267, P1244, DOI 10.1001/jama.267.9.1244
   *CONS AC HLTH CTR, 2009, CAHCIM DEF INT MED
   Danescu LG, 2009, ENDOCRINE, V35, P11, DOI 10.1007/s12020-008-9115-5
   Delva Pietro, 2003, Molecular Aspects of Medicine, V24, P63, DOI 10.1016/S0098-2997(02)00092-4
   Dixon KM, 2005, J STEROID BIOCHEM, V97, P137, DOI 10.1016/j.jsbmb.2005.06.006
   DJURHUUS MS, 1995, DIABETIC MED, V12, P664, DOI 10.1111/j.1464-5491.1995.tb00566.x
   Dobnig H, 2008, ARCH INTERN MED, V168, P1340, DOI 10.1001/archinte.168.12.1340
   DUBEY A, 1989, DRUGS, V37, P1, DOI 10.2165/00003495-198937010-00001
   Epel ES, 2009, HORM-INT J ENDOCRINO, V8, P7, DOI 10.14310/horm.2002.1217
   Eschenauer G, 2006, AM J HEALTH-SYST PH, V63, P26, DOI 10.2146/ajhp050148
   Ford ES, 2007, OBESITY, V15, P1139, DOI 10.1038/oby.2007.628
   GREENBERG S, 1990, J CLIN PHARMACOL, V30, P596, DOI 10.1002/j.1552-4604.1990.tb01862.x
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   He Ka, 2006, J Cardiometab Syndr, V1, P351, DOI 10.1111/j.1559-4564.2006.05702.x
   Holick MF, 2007, NEW ENGL J MED, V357, P266, DOI 10.1056/NEJMra070553
   Hollis BW, 2005, J NUTR, V135, P317, DOI 10.1093/jn/135.2.317
   HWANG DL, 1993, J CLIN ENDOCR METAB, V76, P549, DOI 10.1210/jc.76.3.549
   Kao WHL, 1999, ARCH INTERN MED, V159, P2151, DOI 10.1001/archinte.159.18.2151
   Kelly G S, 2001, Altern Med Rev, V6, P293
   Kim WS, 2001, INVEST NEW DRUG, V19, P81, DOI 10.1023/A:1006481423298
   KISHI H, 1975, RES COMMUN CHEM PATH, V12, P533
   KISHI T, 1977, RES COMMUN CHEM PATH, V17, P157
   Kleefstra N, 2007, DIABETES CARE, V30, P1092, DOI 10.2337/dc06-2192
   Kobayashi K, 1998, NIPPON NOGEIK KAISHI, V72, P153
   KUMAR J, 2009, PEDIATRICS      0803
   Lamperti C, 2005, ARCH NEUROL-CHICAGO, V62, P1709, DOI 10.1001/archneur.62.11.1709
   Langsjoen P, 1994, MOL ASPECTS MED S, pS265
   Lau FC, 2008, MOL CELL BIOCHEM, V317, P1, DOI 10.1007/s11010-008-9744-2
   Lazarou J, 1998, JAMA-J AM MED ASSOC, V279, P1200, DOI 10.1001/jama.279.15.1200
   LIEL Y, 1988, CALCIFIED TISSUE INT, V43, P199, DOI 10.1007/BF02555135
   Lima MD, 2009, DIABETES RES CLIN PR, V83, P257, DOI 10.1016/j.diabres.2008.11.019
   Lima MDL, 1998, DIABETES CARE, V21, P682, DOI 10.2337/diacare.21.5.682
   LINDEN V, 1974, BRIT MED J, V3, P647, DOI 10.1136/bmj.3.5932.647
   Linnane AW, 2002, FREE RADICAL RES, V36, P445, DOI 10.1080/10715760290021306
   Mechanick Jeffrey I, 2003, Endocr Pract, V9, P417
   Melamed ML, 2008, ARTERIOSCL THROM VAS, V28, P1179, DOI 10.1161/ATVBAHA.108.165886
   MULLER K, 1992, CYTOKINE, V4, P506, DOI 10.1016/1043-4666(92)90012-G
   Nagpal S, 2005, ENDOCR REV, V26, P662, DOI 10.1210/er.2004-0002
   Nahin Richard L, 2009, Natl Health Stat Report, P1
   Neal R, 2001, J ALTERN COMPLEM MED, V7, pS19
   Nemerovski CW, 2009, PHARMACOTHERAPY, V29, P691, DOI 10.1592/phco.29.6.691
   Palomer X, 2008, DIABETES OBES METAB, V10, P185, DOI 10.1111/j.1463-1326.2007.00710.x
   PAOLISSO G, 1990, DIABETOLOGIA, V33, P511, DOI 10.1007/BF00404136
   Parker J, 2010, MATURITAS, V65, P225, DOI 10.1016/j.maturitas.2009.12.013
   Parsons PA, 2007, BIOGERONTOLOGY, V8, P233, DOI 10.1007/s10522-007-9080-z
   Pelton R., 2001, DRUG INDUCED NUTR DE
   PENUMATHSA SV, 2007, J AM COLL NUTR, V25, pH820
   Pilz S, 2008, J CLIN ENDOCR METAB, V93, P3927, DOI 10.1210/jc.2008-0784
   Preuss H G, 1998, Curr Opin Clin Nutr Metab Care, V1, P509, DOI 10.1097/00075197-199811000-00005
   Ravina A, 1999, DIABETIC MED, V16, P164, DOI 10.1046/j.1464-5491.1999.00004.x
   REIS JP, 2009, PEDIATRICS      0803
   ROMERO FG, 2002, ACTA DIABETOL, V39, P209
   Rosenfeldt FL, 2007, J HUM HYPERTENS, V21, P297, DOI 10.1038/sj.jhh.1002138
   Rötig A, 2000, LANCET, V356, P391, DOI 10.1016/S0140-6736(00)02531-9
   Scragg R, 2007, AM J HYPERTENS, V20, P713, DOI 10.1016/j.amjhyper.2007.01.017
   SEELIG M, 1989, AM J CARDIOL, V63, pG4, DOI 10.1016/0002-9149(89)90213-0
   Singh RB, 1999, J HUM HYPERTENS, V13, P203, DOI 10.1038/sj.jhh.1000778
   Smith SM, 2009, AM J CLIN NUTR, V89, P1092, DOI 10.3945/ajcn.2008.27189
   Song YQ, 2007, AM J CLIN NUTR, V85, P1068, DOI 10.1093/ajcn/85.4.1068
   STEARNS DM, 1995, FASEB J, V9, pA451
   Sugden JA, 2008, DIABETIC MED, V25, P320, DOI 10.1111/j.1464-5491.2007.02360.x
   Takase B, 2004, CLIN CARDIOL, V27, P223, DOI 10.1002/clc.4960270411
   Targher G, 2006, CLIN ENDOCRINOL, V65, P593, DOI 10.1111/j.1365-2265.2006.02633.x
   Thibault A, 1996, CLIN CANCER RES, V2, P483
   Vieth R, 1999, AM J CLIN NUTR, V69, P842
   Vincent JB, 2000, J NUTR, V130, P715, DOI 10.1093/jn/130.4.715
   Volpe SL, 2008, CRIT REV FOOD SCI, V48, P293, DOI 10.1080/10408390701326235
   Wang TJ, 2008, CIRCULATION, V117, P503, DOI 10.1161/CIRCULATIONAHA.107.706127
   WEBB AR, 1988, J CLIN ENDOCR METAB, V67, P373, DOI 10.1210/jcem-67-2-373
   Xiang W, 2005, AM J PHYSIOL-ENDOC M, V288, pE125, DOI 10.1152/ajpendo.00224.2004
   Yokogoshi H, 1998, NEUROCHEM RES, V23, P667, DOI 10.1023/A:1022490806093
   Yu BP, 2006, MECH AGEING DEV, V127, P436, DOI 10.1016/j.mad.2006.01.023
   Zafra-Stone S., 2007, Nutr. Biochem. Chromium, P183, DOI [10.1016/B978-044453071-4/50010-2, DOI 10.1016/B978-044453071-4/50010-2]
   Zafra-Stone S, 2007, MOL NUTR FOOD RES, V51, P675, DOI 10.1002/mnfr.200700002
   Zita C, 2003, BIOFACTORS, V18, P185, DOI 10.1002/biof.5520180221
NR 81
TC 0
Z9 0
U1 0
U2 0
PU DOUGMAR PUBLISHING GROUP INC
PI HAMILTON
PA 1 HUNTER ST E STE G-100, HAMILTON, ONTARIO L8N-3W1, CANADA
SN 1875-6859
J9 J MENS HEALTH
JI J. Mens Health
PD JUN
PY 2010
VL 7
IS 2
BP 145
EP 158
DI 10.1016/j.jomh.2010.01.002
PG 14
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 687WO
UT WOS:000284809100005
DA 2025-06-11
ER

PT J
AU Devaraj, S
   Wang-Polagruto, J
   Polagruto, J
   Keen, CL
   Jialal, I
AF Devaraj, Sridevi
   Wang-Polagruto, Janice
   Polagruto, John
   Keen, Carl L.
   Jialal, Ishwarlal
TI High-fat, energy-dense, fast-food-style breakfast results in an increase
   in oxidative stress in metabolic syndrome
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID ENDOTHELIAL FUNCTION; DIET
AB The metabolic syndrome (MetS) is associated with an increased incidence of diabetes and coronary heart disease. Postprandial lipemia is a prominent feature of dyslipidemia in both type 2 diabetes mellitus and MetS and is also associated with coronary heart disease. Oxidative stress and inflammation are pivotal in all stages of atherosclerosis; however, there is a paucity of data on postprandial oxidative stress, and inflammation in subjects with MetS. Thus, the primary aim of this study was to compare the postprandial effects of an energy-dense, high-fat, fast-food-style (FFS) meal with an American Heart Association (AHA)-recommended heart-healthy meal on biomarkers of oxidative stress and inflammation in subjects with MetS. A total of 11 subjects with MetS completed the study. Glucose levels were significantly increased 2 hours after both FFS and AHA diets (P<.0001), and high-density lipoprotein cholesterol levels significantly decreased in FFS diet but not in the AHA diet (P for interaction<.05). Total triglyceride levels significantly increased postprandially only in the FFS meal but not in the AHA meal (P for interaction=.03). Plasma thiobarbituric acid reactive substances and malondialdehyde + hydroxynonenal increased significantly with time in both dietary groups, and the postprandial increase was greater in the FFS diet compared to the AHA diet (P<.0005). Serum high-sensitivity C-reactive protein, interleukin 6, and tumor necrosis factor levels did not change with time or dietary treatment. The postprandial increase in interleukin 1b was significantly higher with the FFS meal, thus resulting in significant differences between both treatments (P for interaction=.03). Thus, in subjects with MetS, consumption of an energy-dense, fatty meal (FFS breakfast) results in increased postprandial oxidative stress compared to a heart-healthy meal (AHA). (C) 2008 Elsevier Inc. All rights reserved.
C1 [Devaraj, Sridevi; Jialal, Ishwarlal] Univ Calif Davis, Med Ctr, Lab Atherosclerosis & Metab Res, Sacramento, CA 95817 USA.
   [Wang-Polagruto, Janice; Polagruto, John; Keen, Carl L.] Univ Calif Davis, Med Ctr, Dep Pathol & Nutr, Sacramento, CA 95817 USA.
   [Jialal, Ishwarlal] VANCHS, Mather, CA 95655 USA.
C3 University of California System; University of California Davis;
   University of California System; University of California Davis
RP Jialal, I (corresponding author), Univ Calif Davis, Med Ctr, Lab Atherosclerosis & Metab Res, Sacramento, CA 95817 USA.
EM ishwarlal.jialal@ucdm.ucdavis.edu
RI Jialal, Ishwarlal/AAG-6218-2019
FU NCCIH NIH HHS [K24 AT000596, K24 AT 00596] Funding Source: Medline
CR Burdge GC, 2005, BRIT J NUTR, V93, P3, DOI 10.1079/BJN20041282
   Devaraj S, 2005, J CLIN ENDOCR METAB, V90, P4549, DOI 10.1210/jc.2005-0069
   Devaraj S, 2006, J CLIN ENDOCR METAB, V91, P4489, DOI 10.1210/jc.2006-0299
   Esposito K, 2003, AM J CLIN NUTR, V78, P1135, DOI 10.1093/ajcn/78.6.1135
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Kolovou GD, 2006, EUR J CARDIOV PREV R, V13, P661, DOI 10.1097/01.hjr.0000224490.10845.26
   Lundman P, 2007, NUTR METAB CARDIOVAS, V17, P195, DOI 10.1016/j.numecd.2005.11.009
   Mathur S, 2002, J NUTR, V132, P3663, DOI 10.1093/jn/132.12.3663
   Motton DD, 2007, AM J CLIN NUTR, V85, P60, DOI 10.1093/ajcn/85.1.60
   O'Byrne DJ, 2002, AM J CLIN NUTR, V76, P1367, DOI 10.1093/ajcn/76.6.1367
   PASTROMAS S, 2007, INT J CARDIOL
   Rana JS, 2007, DIABETES OBES METAB, V9, P218, DOI 10.1111/j.1463-1326.2006.00594.x
   Saely CH, 2007, HORM METAB RES, V39, P642, DOI 10.1055/s-2007-985822
   Samaha FF, 2003, NEW ENGL J MED, V348, P2074, DOI 10.1056/NEJMoa022637
   Tsai WC, 2004, CLIN SCI, V106, P315, DOI 10.1042/CS20030227
   Ursini F, 2002, BIOL CHEM, V383, P599, DOI 10.1515/BC.2002.062
   Ursini F, 1998, FREE RADICAL BIO MED, V25, P250, DOI 10.1016/S0891-5849(98)00044-6
   Williams MJA, 1999, J AM COLL CARDIOL, V33, P1050, DOI 10.1016/S0735-1097(98)00681-0
NR 18
TC 120
Z9 135
U1 0
U2 11
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUN
PY 2008
VL 57
IS 6
BP 867
EP 870
DI 10.1016/j.metabol.2008.02.016
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 312BF
UT WOS:000256643400020
PM 18502272
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Cisternas, P
   Gherardelli, C
   Gutierrez, J
   Salazar, P
   Mendez-Orellana, C
   Wong, GW
   Inestrosa, NC
AF Cisternas, Pedro
   Gherardelli, Camila
   Gutierrez, Joel
   Salazar, Paulina
   Mendez-Orellana, Carolina
   Wong, G. William
   Inestrosa, Nibaldo C.
TI Adiponectin and resistin modulate the progression of Alzheimer's disease
   in a metabolic syndrome model
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE adiponectin; resistin; obesity; Alzheimer ' s disease; glucose
   metabolism
ID CEREBRAL GLUCOSE-UPTAKE; HIGH-FAT DIET; INSULIN-RESISTANCE; MOUSE MODEL;
   OXIDATIVE STRESS; COGNITIVE IMPAIRMENT; AMYLOID-BETA; NITRIC-OXIDE;
   IN-VIVO; A-BETA
AB Metabolic syndrome (MetS), a cluster of metabolic conditions that include obesity, hyperlipidemia, and insulin resistance, increases the risk of several aging-related brain diseases, including Alzheimer's disease (AD). However, the underlying mechanism explaining the link between MetS and brain function is poorly understood. Among the possible mediators are several adipose-derived secreted molecules called adipokines, including adiponectin (ApN) and resistin, which have been shown to regulate brain function by modulating several metabolic processes. To investigate the impact of adipokines on MetS, we employed a diet-induced model to induce the various complications associated with MetS. For this purpose, we administered a high-fat diet (HFD) to both WT and APP/PSN1 mice at a pre-symptomatic disease stage. Our data showed that MetS causes a fast decline in cognitive performance and stimulates A beta(42) production in the brain. Interestingly, ApN treatment restored glucose metabolism and improved cognitive functions by 50% while decreasing the A beta(42/40) ratio by approximately 65%. In contrast, resistin exacerbated Ab pathology, increased oxidative stress, and strongly reduced glucose metabolism. Together, our data demonstrate that ApN and resistin alterations could further contribute to AD pathology.
C1 [Cisternas, Pedro] Univ Ohiggins, Inst Ciencias Salud, Rancagua, Chile.
   [Gherardelli, Camila; Gutierrez, Joel; Salazar, Paulina; Inestrosa, Nibaldo C.] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Ctr Envejecimiento & Regenerac CARE UC, Dept Biol Celular & Mol, Santiago, Chile.
   [Mendez-Orellana, Carolina] Pontificia Univ Catolica Chile, Fac Med, Dept Ciencias Salud, Carrera Fonoaudiol, Santiago, Chile.
   [Wong, G. William] Johns Hopkins Univ, Sch Med, Dept Physiol, Baltimore, MD USA.
   [Wong, G. William] Johns Hopkins Univ, Sch Med, Ctr Metab & Obes Res, Baltimore, MD USA.
   [Inestrosa, Nibaldo C.] Univ Magallanes, Ctr Excelencia Biomed Magallanes CEBIMA, Punta Arenas, Chile.
C3 Universidad de O'Higgins; Pontificia Universidad Catolica de Chile;
   Pontificia Universidad Catolica de Chile; Johns Hopkins University;
   Johns Hopkins University; Universidad de Magallanes
RP Cisternas, P (corresponding author), Univ Ohiggins, Inst Ciencias Salud, Rancagua, Chile.; Inestrosa, NC (corresponding author), Pontificia Univ Catolica Chile, Fac Ciencias Biol, Ctr Envejecimiento & Regenerac CARE UC, Dept Biol Celular & Mol, Santiago, Chile.; Inestrosa, NC (corresponding author), Univ Magallanes, Ctr Excelencia Biomed Magallanes CEBIMA, Punta Arenas, Chile.
EM pedro.cisternas@uoh.cl; ninestrosa@bio.puc.cl
FU Basal Center of Excellence in Aging and Regeneration [CONICYT-AFB
   170005]; FONDECYT [11160651]
FX This work was supported by grants from the Basal Center of Excellence in
   Aging and Regeneration (CONICYT-AFB 170005) to NI, FONDECYT (no.
   11160651) to PC. We also thank the Sociedad Quimica y Minera de Chile
   (SQM) for the special grants "The Role of K+ on Hypertension and
   Cognition", "The Role of Lithiumin Human Health and Disease", and "Fondo
   interdisciplina del departamento Ciencias de la salud, P. Universidad
   Catolica de Chile" to CM-O, and the Puente Fund of the Universidad de
   O'Higgins.
CR Alquier T, 2001, NEUROSCI LETT, V308, P75, DOI 10.1016/S0304-3940(01)01936-X
   Anderson T, 2024, J NEUROCHEM, V168, P801, DOI 10.1111/jnc.15900
   Arnoldussen IAC, 2014, EUR NEUROPSYCHOPHARM, V24, P1982, DOI 10.1016/j.euroneuro.2014.03.002
   Ashrafi G, 2017, NEURON, V93, P606, DOI 10.1016/j.neuron.2016.12.020
   Bahrami SB, 2017, INTEGR BIOL-UK, V9, P223, DOI 10.1039/c7ib00002b
   Bao J, 2022, J ALZHEIMERS DIS, V85, P863, DOI 10.3233/JAD-215299
   Benedict C, 2004, PSYCHONEUROENDOCRINO, V29, P1326, DOI 10.1016/j.psyneuen.2004.04.003
   Bevins RA, 2006, NAT PROTOC, V1, P1306, DOI 10.1038/nprot.2006.205
   Bolaños JP, 2008, BBA-BIOENERGETICS, V1777, P789, DOI 10.1016/j.bbabio.2008.04.011
   Bouhali T, 2008, ATHEROSCLEROSIS, V196, P262, DOI 10.1016/j.atherosclerosis.2006.10.035
   Butterfield DA, 2019, NAT REV NEUROSCI, V20, P148, DOI 10.1038/s41583-019-0132-6
   Calkins MJ, 2011, HUM MOL GENET, V20, P4515, DOI 10.1093/hmg/ddr381
   CAMPBELL IW, 1995, BIOCHEM BIOPH RES CO, V211, P780, DOI 10.1006/bbrc.1995.1881
   Campos-Peña V, 2017, ANTIOXID REDOX SIGN, V26, P542, DOI 10.1089/ars.2016.6768
   Ceddia RB, 2005, DIABETOLOGIA, V48, P132, DOI 10.1007/s00125-004-1609-y
   Chakrabarti S, 2015, AGING DIS, V6, P282, DOI 10.14336/AD.2014.002
   Chan KH, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0052354
   Chen CY, 2010, AM J PHYSIOL-HEART C, V299, pH193, DOI 10.1152/ajpheart.00431.2009
   Cisternas P, 2019, FRONT CELL NEUROSCI, V13, DOI 10.3389/fncel.2019.00295
   Cisternas P, 2019, MOL NEUROBIOL, V56, P3024, DOI 10.1007/s12035-018-1271-x
   Cisternas P, 2017, NEUROSCI BIOBEHAV R, V80, P316, DOI 10.1016/j.neubiorev.2017.06.004
   Cisternas P, 2016, J BIOL CHEM, V291, P25950, DOI 10.1074/jbc.M116.735373
   Cisternas P, 2015, BBA-MOL BASIS DIS, V1852, P2630, DOI 10.1016/j.bbadis.2015.09.009
   Cox BL, 2015, AM J NUCL MED MOLEC, V5, P1
   Daquinag AC, 2011, CELL STEM CELL, V9, P74, DOI 10.1016/j.stem.2011.05.017
   Demirci S, 2017, CLIN PSYCHOPHARM NEU, V15, P59, DOI 10.9758/cpn.2017.15.1.59
   dos Santos JM, 2012, CELL BIOCHEM FUNCT, V30, P191, DOI 10.1002/cbf.1834
   Dukart J, 2013, NEUROIMAGE-CLIN, V3, P84, DOI 10.1016/j.nicl.2013.07.005
   Duran-Aniotz C, 2016, CURR BIOL, V26, pR806, DOI 10.1016/j.cub.2016.07.060
   Fasshauer M, 2015, TRENDS PHARMACOL SCI, V36, P461, DOI 10.1016/j.tips.2015.04.014
   Fitzpatrick AL, 2009, ARCH NEUROL-CHICAGO, V66, P336, DOI 10.1001/archneurol.2008.582
   Flores-Cordero JA, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23095202
   Gabbouj S, 2019, FRONT NEUROSCI-SWITZ, V13, DOI 10.3389/fnins.2019.00629
   Gherardelli C, 2022, J ALZHEIMERS DIS, V87, P901, DOI 10.3233/JAD-215273
   Gustafson DR, 2010, J NEUROL SCI, V299, P30, DOI 10.1016/j.jns.2010.08.036
   Guzman-Ruiz MA, 2021, BMC NEUROSCI, V22, DOI 10.1186/s12868-021-00620-9
   Ha J, 2023, J GERONTOL A-BIOL, V78, P120, DOI 10.1093/gerona/glac021
   Hahm JR, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9010249
   He KW, 2021, AGING CELL, V20, DOI 10.1111/acel.13514
   Herrero-Mendez A, 2009, NAT CELL BIOL, V11, P747, DOI 10.1038/ncb1881
   Ho L, 2004, FASEB J, V18, P902, DOI 10.1096/fj.03-0978fje
   Hoffmann K, 2016, J ALZHEIMERS DIS, V50, P443, DOI 10.3233/JAD-150817
   Jankowsky JL, 2004, HUM MOL GENET, V13, P159, DOI 10.1093/hmg/ddh019
   Janson J, 2004, DIABETES, V53, P474, DOI 10.2337/diabetes.53.2.474
   Jaworski T, 2010, BBA-MOL BASIS DIS, V1802, P808, DOI 10.1016/j.bbadis.2010.03.005
   Jian Y, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23179921
   Jie L., 2013, Brain Res, V1523, P77, DOI [10.1016/j.brainres.2013.05.041, DOI 10.1016/J.BRAINRES.2013.05.041]
   Ramos-Rodriguez JJ, 2017, MOL NEUROBIOL, V54, P3428, DOI 10.1007/s12035-016-9921-3
   Ramos-Rodriguez JJ, 2016, MOL NEUROBIOL, V53, P2685, DOI 10.1007/s12035-015-9311-2
   Ramos-Rodriguez JJ, 2015, PSYCHONEUROENDOCRINO, V62, P69, DOI 10.1016/j.psyneuen.2015.07.606
   Ramos-Rodriguez JJ, 2014, PSYCHONEUROENDOCRINO, V48, P123, DOI 10.1016/j.psyneuen.2014.06.005
   Kadowaki T, 2006, J CLIN INVEST, V116, P1784, DOI 10.1172/JCI29126
   Kellar D, 2020, LANCET NEUROL, V19, P758, DOI 10.1016/S1474-4422(20)30231-3
   Khandelwal M, 2022, NEUROBIOL DIS, V174, DOI 10.1016/j.nbd.2022.105876
   Kiliaan AJ, 2014, LANCET NEUROL, V13, P913, DOI 10.1016/S1474-4422(14)70085-7
   Kim YJ, 2021, DIABETOL METAB SYNDR, V13, DOI 10.1186/s13098-020-00620-5
   Kizilarslanoglu MC, 2015, TURK J MED SCI, V45, P1040, DOI 10.3906/sag-1403-55
   Leal VD, 2013, CLIN CHIM ACTA, V419, P87, DOI 10.1016/j.cca.2013.02.003
   Letra L, 2019, J ALZHEIMERS DIS, V67, P725, DOI 10.3233/JAD-180669
   LIN JL, 1991, DIABETOLOGIA, V34, P477, DOI 10.1007/BF00403283
   Liu XY, 2019, NEUROCHEM RES, V44, P905, DOI 10.1007/s11064-019-02726-3
   Macdonald IR, 2014, CURR ALZHEIMER RES, V11, P450, DOI 10.2174/1567205011666140505111354
   Marcinnò A, 2022, HELIYON, V8, DOI 10.1016/j.heliyon.2022.e11738
   Matsuda M, 2014, REV ENDOCR METAB DIS, V15, P1, DOI 10.1007/s11154-013-9271-7
   McMurray F, 2016, OBESITY, V24, P2301, DOI 10.1002/oby.21654
   Mcnay EC, 2020, EXP NEUROL, V323, DOI 10.1016/j.expneurol.2019.113076
   Moon B, 2003, AM J PHYSIOL-ENDOC M, V285, pE106, DOI 10.1152/ajpendo.00457.2002
   Mosconi L, 2008, ANN NY ACAD SCI, V1147, P180, DOI 10.1196/annals.1427.007
   Müller WEG, 2017, J CELL SCI, V130, P2747, DOI 10.1242/jcs.204941
   Ng RCL, 2016, MOL NEURODEGENER, V11, DOI 10.1186/s13024-016-0136-x
   Ng TP, 2016, JAMA NEUROL, V73, P456, DOI 10.1001/jamaneurol.2015.4899
   Niccoli T, 2016, CURR BIOL, V26, P2291, DOI [10.1016/j.cub.2016.07.017, 10.1016/j.cub.2016.09.018]
   Osborn LM, 2016, PROG NEUROBIOL, V144, P121, DOI 10.1016/j.pneurobio.2016.01.001
   Osorio RS, 2010, PET CLIN, V5, P15, DOI 10.1016/j.cpet.2009.12.003
   Pearson-Leary J, 2012, J ALZHEIMERS DIS, V30, P413, DOI 10.3233/JAD-2012-112192
   Pegg CC, 2010, J NEUROSCI METH, V187, P8, DOI 10.1016/j.jneumeth.2009.12.002
   Poisnel G, 2012, NEUROBIOL AGING, V33, P1995, DOI 10.1016/j.neurobiolaging.2011.09.026
   Qi Y, 2006, DIABETES, V55, P3083, DOI 10.2337/db05-0615
   Querfurth HW, 2010, NEW ENGL J MED, V362, P329, DOI 10.1056/NEJMra0909142
   Razay G, 2007, ARCH NEUROL-CHICAGO, V64, P93, DOI 10.1001/archneur.64.1.93
   Rivera DS, 2021, FRONT INTEGR NEUROSC, V15, DOI 10.3389/fnint.2021.719076
   Rohm TV, 2022, IMMUNITY, V55, P31, DOI 10.1016/j.immuni.2021.12.013
   Rosen ED, 2014, CELL, V156, P20, DOI 10.1016/j.cell.2013.12.012
   Sah SK, 2017, BIOCHEM BIOPH RES CO, V493, P731, DOI 10.1016/j.bbrc.2017.08.122
   Salas IH, 2018, NEUROBIOL DIS, V113, P82, DOI 10.1016/j.nbd.2018.02.001
   Salas-Venegas V, 2022, FRONT INTEGR NEUROSC, V16, DOI 10.3389/fnint.2022.798995
   Scott TA, 2016, OBESITY, V24, P678, DOI 10.1002/oby.21425
   Serrano-Pozo A, 2011, CSH PERSPECT MED, V1, DOI 10.1101/cshperspect.a006189
   Spires-Jones TL, 2014, NEURON, V82, P756, DOI 10.1016/j.neuron.2014.05.004
   Sui SX, 2020, MEDICINA-LITHUANIA, V56, DOI 10.3390/medicina56100499
   Suman S, 2015, INT J BIOL SCI, V11, P274, DOI 10.7150/ijbs.10684
   Szablewski L, 2017, J ALZHEIMERS DIS, V55, P1307, DOI 10.3233/JAD-160841
   Toyama K, 2015, SCI REP-UK, V5, DOI 10.1038/srep10844
   Tsytsarev V, 2012, J NEUROSCI METH, V203, P136, DOI 10.1016/j.jneumeth.2011.09.005
   Uranga RM, 2019, FRONT NEUROSCI-SWITZ, V13, DOI 10.3389/fnins.2019.00513
   Van Cauwenberghe C, 2016, GENET MED, V18, P421, DOI 10.1038/gim.2015.117
   Vanhanen M, 2006, NEUROLOGY, V67, P843, DOI 10.1212/01.wnl.0000234037.91185.99
   Vannucci SJ, 1998, BRAIN RES, V797, P1, DOI 10.1016/S0006-8993(98)00103-6
   Várhelyi ZP, 2017, FRONT NEUROSCI-SWITZ, V11, DOI 10.3389/fnins.2017.00199
   Vu V, 2013, J MOL ENDOCRINOL, V51, P155, DOI 10.1530/JME-13-0059
   Walker JM, 2017, NEUROBIOL DIS, V100, P87, DOI 10.1016/j.nbd.2017.01.004
   WALSH RN, 1976, PSYCHOL BULL, V83, P482, DOI 10.1037/0033-2909.83.3.482
   Wang J, 2017, NAT REV NEUROL, V13, P612, DOI 10.1038/nrneurol.2017.111
   Waragai M, 2020, J ALZHEIMERS DIS, V76, P1249, DOI 10.3233/JAD-200416
   Waragai M, 2017, ANN CLIN TRANSL NEUR, V4, P591, DOI 10.1002/acn3.436
   Waragai M, 2016, J ALZHEIMERS DIS, V52, P1453, DOI 10.3233/JAD-151116
   Weisová P, 2009, J NEUROSCI, V29, P2997, DOI 10.1523/JNEUROSCI.0354-09.2009
   Willette AA, 2015, JAMA NEUROL, V72, P1013, DOI 10.1001/jamaneurol.2015.0613
   Winkler EA, 2015, NAT NEUROSCI, V18, P521, DOI 10.1038/nn.3966
   Xiong J, 2022, METAB BRAIN DIS, V37, P1941, DOI 10.1007/s11011-022-01029-x
   Xu WL, 2011, NEUROLOGY, V76, P1568, DOI 10.1212/WNL.0b013e3182190d09
   Yamauchi T, 2002, NAT MED, V8, P1288, DOI 10.1038/nm788
   Yan XD, 2022, J ALZHEIMERS DIS, V85, P343, DOI 10.3233/JAD-215063
   Yates KF, 2012, ARTERIOSCL THROM VAS, V32, P2060, DOI 10.1161/ATVBAHA.112.252759
   Zhao Y, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/316523
   Zhou Q, 2018, METAB BRAIN DIS, V33, P1661, DOI 10.1007/s11011-018-0274-7
   Ziemke F, 2010, AM J CLIN NUTR, V91, p258S, DOI 10.3945/ajcn.2009.28449C
NR 117
TC 10
Z9 10
U1 0
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD SEP 4
PY 2023
VL 14
AR 1237796
DI 10.3389/fendo.2023.1237796
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA S1CB4
UT WOS:001068605300001
PM 37732123
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU DeLeve, LD
   Wang, XD
   Kanel, GC
   Atkinson, RD
   McCuskey, RS
AF DeLeve, Laurie D.
   Wang, Xiangdong
   Kanel, Gary C.
   Atkinson, Roscoe D.
   McCuskey, Robert S.
TI Prevention of hepatic fibrosis in a murine model of metabolic syndrome
   with nonalcoholic steatohepatitis
SO AMERICAN JOURNAL OF PATHOLOGY
LA English
DT Article
ID EXTRACELLULAR-MATRIX; INSULIN-RESISTANCE; GENE-EXPRESSION; RECEPTOR;
   LEPTIN; PLASMA; ATHEROSCLEROSIS; LIPOPROTEIN; ACTIVATION; STEATOSIS
AB The endocannabinoid pathway plays an important role in the regulation of appetite and body weight, hepatic lipid metabolism, and fibrosis. Blockade of the endocannabinoid receptor CBI with SR141716 promotes weight loss, reduces hepatocyte fatty acid synthesis, and is antifibrotic. D-4F, an apolipoprotein A-1 mimetic with antioxidant properties, is currently in clinical trials for the treatment of atherosclerosis. C57BL/6J mice were fed a high-fat diet for 7 months, followed by a 2.5-month treatment with either SR141716 or D-417. SR141716 markedly improved body weight, liver weight, serum transaminases, insulin resistance, hyperglycemia, hypercholesterolemia, hyerleptinemia, and oxidative stress, accompanied by the significant prevention of fibrosis progression. D-4F improved hypercholesterolemia and hyperleptinemia without improvement in body weight, steatohepatitis, insulin resistance, or oxidative stress, and yet, there was significant prevention of fibrosis. D-4F prevented culture-induced activation of stellate cells in vitro. In summary, C57BL/6J mice given a high-fat diet developed features of metabolic syndrome with nonalcoholic steatohepatitis and fibrosis. Both SR141716 and D-417 prevented progression of fibrosis after onset of steatohepatitis, ie, a situation comparable to a common clinical scenario, with D-4F seeming to have a more general antifibrotic effect. Either compound therefore has the potential to be of clinical benefit.
C1 [DeLeve, Laurie D.; Wang, Xiangdong] Univ So Calif, Keck Sch Med, Div Gastrointestinal & Liver Dis, Los Angeles, CA 90033 USA.
   [DeLeve, Laurie D.; Wang, Xiangdong] Univ So Calif, Keck Sch Med, Res Ctr Liver Dis, Los Angeles, CA 90033 USA.
   [McCuskey, Robert S.] Univ Arizona, Dept Cell Biol & Anat, Tucson, AZ USA.
   [Kanel, Gary C.; Atkinson, Roscoe D.] Univ So Calif, Keck Sch Med, Dept Pathol, Los Angeles, CA 90033 USA.
C3 University of Southern California; University of Southern California;
   University of Arizona; University of Southern California
RP DeLeve, LD (corresponding author), Univ So Calif, Keck Sch Med, Div GI Liver Dis, 2011 Zonal Ave,HMR603, Los Angeles, CA 90033 USA.
EM deleve@usc.edu
RI DeLeve, Laurie/F-3549-2012
FU National Institutes of Health [DK66423]; Morphology Core of the
   University of Southern California Research Center for Liver Diseases;
   Nonparerchymal Liver Cell Core of the Southern California Research
   Center for Alcoholic Liver and Pancreatic Diseases and Cirrhosis
FX Supported by the National Institutes of Health (grant DK66423), the
   Morphology Core of the University of Southern California Research Center
   for Liver Diseases, and the Nonparerchymal Liver Cell Core of the
   Southern California Research Center for Alcoholic Liver and Pancreatic
   Diseases and Cirrhosis.
CR Anantharamaiah GM, 2007, J LIPID RES, V48, P1915, DOI 10.1194/jlr.R700010-JLR200
   Baroni GS, 1998, HEPATOLOGY, V27, P720
   Farrell GC, 2008, ANAT REC, V291, P684, DOI 10.1002/ar.20715
   Gary-Bobo M, 2007, HEPATOLOGY, V46, P122, DOI 10.1002/hep.21641
   Honda H, 2002, HEPATOLOGY, V36, P12, DOI 10.1053/jhep.2002.33684
   Ikejima K, 2002, GASTROENTEROLOGY, V122, P1399, DOI 10.1053/gast.2002.32995
   Julien B, 2005, GASTROENTEROLOGY, V128, P742, DOI 10.1053/j.gastro.2004.12.050
   Lin SB, 2006, MOL ENDOCRINOL, V20, P3376, DOI 10.1210/me.2006-0177
   Macdonald GA, 2001, J GASTROEN HEPATOL, V16, P599, DOI 10.1046/j.1440-1746.2001.02445.x
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   MCCUSKEY RS, 1990, J ELECTRON MICR TECH, V14, P237, DOI 10.1002/jemt.1060140305
   McCuskey RS, 2004, HEPATOLOGY, V40, P386, DOI 10.1002/hep.20302
   MCCUSKEY RS, 1986, MICROCIRCULATORY TEC, P247
   Merat S, 1999, ARTERIOSCL THROM VAS, V19, P1223, DOI 10.1161/01.ATV.19.5.1223
   Navab M, 2004, CIRCULATION, V109, P3215, DOI 10.1161/01.CIR.0000134275.90823.87
   Navab M, 2002, CIRCULATION, V105, P290, DOI 10.1161/hc0302.103711
   Nieto N, 2002, J BIOL CHEM, V277, P9853, DOI 10.1074/jbc.M110506200
   Osei-Hyiaman D, 2005, J CLIN INVEST, V115, P1298, DOI 10.1172/JCI200523057
   Poli Giuseppe, 2000, Molecular Aspects of Medicine, V21, P49, DOI 10.1016/S0098-2997(00)00004-2
   Saxena NK, 2003, J CELL BIOCHEM, V89, P311, DOI 10.1002/jcb.10494
   Schneiderhan W, 2001, HEPATOLOGY, V34, P729, DOI 10.1053/jhep.2001.27828
   Teixeira-Clerc F, 2006, NAT MED, V12, P671, DOI 10.1038/nm1421
   TIETZE F, 1969, ANAL BIOCHEM, V27, P502, DOI 10.1016/0003-2697(69)90064-5
   TSUKAMOTO H, 1995, J GASTROEN HEPATOL, V10, pS50, DOI 10.1111/j.1440-1746.1995.tb01798.x
   TSUKAMOTO H, 1986, HEPATOLOGY, V6, P814, DOI 10.1002/hep.1840060503
   WALLIN B, 1993, ANAL BIOCHEM, V208, P10, DOI 10.1006/abio.1993.1002
   WONG SHY, 1987, CLIN CHEM, V33, P214
   Xia Z, 2002, J BIOL CHEM, V277, P45874, DOI 10.1074/jbc.M207281200
NR 28
TC 85
Z9 96
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9440
EI 1525-2191
J9 AM J PATHOL
JI Am. J. Pathol.
PD OCT
PY 2008
VL 173
IS 4
BP 993
EP 1001
DI 10.2353/ajpath.2008.070720
PG 9
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA 354OD
UT WOS:000259648000009
PM 18772330
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Kahl, KG
   Utanir, F
   Schweiger, U
   Krüger, TH
   Frieling, H
   Bleich, S
   Gutberlet, M
   Hartung, D
AF Kahl, Kai G.
   Utanir, Ferdi
   Schweiger, Ulrich
   Krueger, Tillmann H.
   Frieling, Helge
   Bleich, Stefan
   Gutberlet, Marcel
   Hartung, Dagmar
TI Reduced muscle mass in middle-aged depressed patients is associated with
   male gender and chronicity
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Depression; Physical health; Neuroendocrinology; Internal medicine;
   Magnetic resonance imaging
ID PERICARDIAL ADIPOSE-TISSUE; SKELETAL-MUSCLE; METABOLIC SYNDROME;
   SARCOPENIA ORIGINS; PHYSICAL-ACTIVITY; BIPOLAR DISORDER;
   NATIONAL-HEALTH; OLDER MEN; EXERCISE; TESTOSTERONE
AB Objective: Reduced muscle mass is a characteristic finding in sarcopenia, the central element of physical frailty syndrome, and a major cause of physical function decay, morbidity and mortality in the elderly. Studies so far demonstrated reduced muscle mass in depressed patients with an average age over 60 years. An open question is whether muscle mass reduction is already observed earlier. Therefore, muscle mass was assessed in middle-aged male and female depressive patients, and the findings were related to indicators of hypothalamus pituitary adrenal axis activation, lifestyle factors, endocrine and immune measures.
   Methods: Sixty-seven depressed patients (mean age 38.6y; 582% female) and 26 healthy volunteers (mean age 40.5y; 61.5% female) were included. Muscle mass, adrenal gland volume, and intra-abdominal adipose tissue were assessed by magnetic resonance tomography. Laboratory parameters included fasting cortisol, pro inflammatory cytokines, factors constituting the metabolic syndrome, and relative insulin resistance according to the homeostasis model assessment (HOMA-IR).
   Results: We found significant effects of depression (F = 42; P = 0.043) and gender (F = 182; P<0.001) on muscle mass. Muscle mass was reduced in depressed men compared to healthy men (F = 3.4; P = 0.044), particularly in those with chronic depression. In contrast, no such association was observed in depressed females. Adrenal gland volume and intra-abdominal fat was increased in depressed men and women, although not significantly. Correlations were observed for muscle mass with the amount of self-reported exercise and depression severity, and for depression severity with self-reported exercise. Further findings comprised lower self reported activity and higher cortisol concentrations in depressed male and female compared to healthy pro bands.
   Conclusions: Muscle mass is reduced in middle-aged depressed men, particularly those with chronic disease course. This association is not observed in depressed females, possibly pointing to the role of female sex steroids in maintaining muscle mass. The increase of adrenal gland volume in depressed patients may point to the role of a dysregulated hypothalamus-pituitary-adrenal system. The inverse association of exercise with muscle mass demonstrates the importance of physical activity. Looking at the long term consequences of reduced muscle mass, interventions to preserve and rebuild muscle mass in depression-such as structured exercise interventions -should be recommended.
   Significant outcomes: Muscle mass is decreased in male patients with major depressive disorder, particular those with chronic disease course. This difference was not observed in female depressed patients. The extent of muscle mass reduction is correlated to depression severity and inversely to physical activity, pointing to the role of depression associated inactivity. Low muscle mass is a risk factor for physical frailty, therefore interventions aiming at improving physical fitness may be recommended. Limitations: Sex steroids were not assessed in the study groups. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Kahl, Kai G.; Utanir, Ferdi; Krueger, Tillmann H.; Frieling, Helge; Bleich, Stefan] Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Carl Neuberg Str 1, D-30625 Hannover, Germany.
   [Gutberlet, Marcel; Hartung, Dagmar] Hannover Med Sch, Dep Diagnost & Intervent Radiol, Hannover, Germany.
   [Schweiger, Ulrich] Univ Lubeck, Dep Psychiat & Psychotherapy, Lubeck, Germany.
C3 Hannover Medical School; Hannover Medical School; University of Lubeck
RP Kahl, KG (corresponding author), Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM kahl.kai@mh-hannover.de
RI Bleich, Stefan/ABC-1796-2020; Kruger, Tillmann/F-3493-2012; Gutberlet,
   Matthias/AAL-2699-2021; Frieling, Helge/C-5299-2015
CR Batsis J.A., 2016, CLIN NUTR
   Benatti FB, 2015, NAT REV RHEUMATOL, V11, P86, DOI 10.1038/nrrheum.2014.193
   Bhasin S, 1996, NEW ENGL J MED, V335, P1, DOI 10.1056/NEJM199607043350101
   Bhasin S, 2010, J CLIN ENDOCR METAB, V95, P2536, DOI 10.1210/jc.2009-2354
   Björntorp P, 1999, DRUGS, V58, P13
   Byeon CH, 2016, KOREAN J FAM MED, V37, P37, DOI 10.4082/kjfm.2016.37.1.37
   Carroll BJ, 2012, ACTA PSYCHIAT SCAND, V125, P478, DOI 10.1111/j.1600-0447.2011.01821.x
   Cermak NM, 2012, AM J CLIN NUTR, V96, P1454, DOI 10.3945/ajcn.112.037556
   Chen LK, 2016, J AM MED DIR ASSOC, V17, DOI 10.1016/j.jamda.2016.05.016
   Chen XJ, 2014, CLIN INTERV AGING, V9, P433, DOI 10.2147/CIA.S45300
   Cizza G, 2010, HORM METAB RES, V42, P467, DOI 10.1055/s-0030-1252020
   Cohen S, 2015, NAT REV DRUG DISCOV, V14, P58, DOI 10.1038/nrd4467
   Cruz-Jentoft AJ, 2010, AGE AGEING, V39, P412, DOI 10.1093/ageing/afq034
   Cuppett M, 2002, J ATHL TRAINING, V37, P281
   Denison HJ, 2015, CLIN INTERV AGING, V10, P859, DOI 10.2147/CIA.S55842
   Diel P, 2014, ACTA PHYSIOL, V212, P14, DOI 10.1111/apha.12341
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Eyre H, 2012, BRAIN BEHAV IMMUN, V26, P251, DOI 10.1016/j.bbi.2011.09.015
   Fan JJ, 2016, MEDIAT INFLAMM, V2016, DOI 10.1155/2016/1438686
   Ford AH, 2016, PSYCHONEUROENDOCRINO, V64, P57, DOI 10.1016/j.psyneuen.2015.11.012
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Garcia JM, 2006, CANCER-AM CANCER SOC, V106, P2583, DOI 10.1002/cncr.21889
   Grant BF, 2016, JAMA PSYCHIAT, V73, P39, DOI 10.1001/jamapsychiatry.2015.2132
   Greggersen W, 2011, EUR ARCH PSY CLIN N, V261, P551, DOI 10.1007/s00406-011-0194-6
   Grinspoon S, 1996, J CLIN ENDOCR METAB, V81, P4051, DOI 10.1210/jc.81.11.4051
   Hallgren M, 2016, NEUROPSYCH DIS TREAT, V12, P2715, DOI 10.2147/NDT.S121782
   Hubbard RE, 2009, J CELL MOL MED, V13, P3103, DOI 10.1111/j.1582-4934.2009.00733.x
   Hughes VA, 2002, AM J CLIN NUTR, V76, P473, DOI 10.1093/ajcn/76.2.473
   Janssen I, 2002, J AM GERIATR SOC, V50, P889, DOI 10.1046/j.1532-5415.2002.50216.x
   Kahl KG, 2016, J AFFECT DISORDERS, V192, P91, DOI 10.1016/j.jad.2015.12.015
   Kahl KG, 2015, PSYCHONEUROENDOCRINO, V58, P1, DOI 10.1016/j.psyneuen.2015.04.008
   Kerling A, 2016, BRAIN BEHAV, V6, DOI 10.1002/brb3.469
   Kessing LV, 2011, PSYCHONEUROENDOCRINO, V36, P19, DOI 10.1016/j.psyneuen.2010.05.007
   KHALEELI AA, 1983, CLIN ENDOCRINOL, V18, P155, DOI 10.1111/j.1365-2265.1983.tb03198.x
   Kim NH, 2011, J AM GERIATR SOC, V59, P2062, DOI 10.1111/j.1532-5415.2011.03664.x
   Kitajima Y, 2016, J ENDOCRINOL, V229, P267, DOI 10.1530/JOE-15-0476
   Landi F, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2015-008281
   Landi F, 2015, CLIN LIVER DIS, V19, P367, DOI 10.1016/j.cger.2015.04.005
   Liu CK, 2016, AGE, V38, DOI 10.1007/s11357-015-9864-z
   Liu JK, 2010, DIABETES CARE, V33, P1635, DOI 10.2337/dc10-0245
   Manini TM, 2012, J GERONTOL A-BIOL, V67, P28, DOI 10.1093/gerona/glr010
   Markianos M, 2007, J AFFECT DISORDERS, V101, P255, DOI 10.1016/j.jad.2006.11.013
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mauvais-Jarvis F, 2011, TRENDS ENDOCRIN MET, V22, P24, DOI 10.1016/j.tem.2010.10.002
   McClung JM, 2006, J APPL PHYSIOL, V100, P2012, DOI 10.1152/japplphysiol.01583.2005
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Penninx BW., 2016, NEUROSCI BIOBEHAV RE
   Perandini LA, 2014, J APPL PHYSIOL, V117, P639, DOI 10.1152/japplphysiol.00486.2014
   Pöllänen E, 2011, AGING CELL, V10, P650, DOI 10.1111/j.1474-9726.2011.00701.x
   Psutka SP, 2014, CANCER-AM CANCER SOC, V120, P2910, DOI 10.1002/cncr.28798
   Remigio-Baker RA, 2015, BMC PSYCHIATRY, V15, DOI 10.1186/s12888-015-0604-9
   Rosenberg IH, 1997, J NUTR, V127, pS990, DOI 10.1093/jn/127.5.990S
   Rosenberg IH, 2011, CLIN GERIATR MED, V27, P337, DOI 10.1016/j.cger.2011.03.003
   Schuch F, 2017, J AFFECT DISORDERS, V210, P139, DOI 10.1016/j.jad.2016.10.050
   Schuch FB, 2016, REV BRAS PSIQUIATR, V38, P247
   Schuch FB, 2016, PSYCHIAT RES, V241, P47, DOI 10.1016/j.psychres.2016.04.054
   Schweiger JU, 2016, BRAIN BEHAV, V6, DOI 10.1002/brb3.489
   Seidman SN, 2002, AM J PSYCHIAT, V159, P456, DOI 10.1176/appi.ajp.159.3.456
   Song MR, 2012, PUBLIC HEALTH NURS, V29, P208, DOI 10.1111/j.1525-1446.2011.00986.x
   Soysal P, 2016, AGEING RES REV, V31, P1, DOI 10.1016/j.arr.2016.08.006
   Steffl M, 2015, PHYSIOL RES, V64, P419, DOI 10.33549/physiolres.932802
   Stetler C, 2011, PSYCHOSOM MED, V73, P114, DOI 10.1097/PSY.0b013e31820ad12b
   Stice JP, 2008, MOL MED, V14, P517, DOI 10.2119/2008-00026.Stice
   Stubbs B, 2016, ACTA PSYCHIAT SCAND, V134, P546, DOI 10.1111/acps.12654
   Stubbs B, 2016, J AFFECT DISORDERS, V190, P249, DOI 10.1016/j.jad.2015.10.010
   Sugiura T, 2006, J PHYSIOL SCI, V56, P393, DOI 10.2170/physiolsci.RP006906
   Tak E, 2013, AGEING RES REV, V12, P329, DOI 10.1016/j.arr.2012.10.001
   Tartibian Bakhtyar, 2015, Post Reprod Health, V21, P9, DOI 10.1177/2053369114565708
   Toth MJ, 2005, AM J PHYSIOL-ENDOC M, V288, pE883, DOI 10.1152/ajpendo.00353.2004
   Van der Kooy K, 2007, INT J GERIATR PSYCH, V22, P613, DOI 10.1002/gps.1723
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vancampfort D., 2016, Sports Medicine, P1
   Vancampfort D, 2016, WORLD PSYCHIATRY, V15, P166, DOI 10.1002/wps.20309
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vaughan L, 2015, CLIN INTERV AGING, V10, DOI 10.2147/CIA.S69632
   Viscogliosi G, 2014, J AM GERIATR SOC, V62, P1607, DOI 10.1111/jgs.12960
   Vitale G., 2016, EUR J INTERN MED
   Walston J, 2002, ARCH INTERN MED, V162, P2333, DOI 10.1001/archinte.162.20.2333
   White JP, 2009, J APPL PHYSIOL, V107, P1420, DOI 10.1152/japplphysiol.00668.2009
   Whooley MA, 1999, ARCH INTERN MED, V159, P484, DOI 10.1001/archinte.159.5.484
   Wu H., 2016, INT J GERIATR PSYCHI
NR 81
TC 10
Z9 10
U1 0
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD JUN 2
PY 2017
VL 76
BP 58
EP 64
DI 10.1016/j.pnpbp.2017.01.009
PG 7
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA EY9LR
UT WOS:000404320600007
PM 28132777
DA 2025-06-11
ER

PT J
AU Schrier, AC
   Ujcic-Voortman, JK
   de Wit, MAS
   Verhoeff, AP
   Kupka, R
   Dekker, J
   Beekman, ATF
AF Schrier, Agnes C.
   Ujcic-Voortman, Joanne K.
   de Wit, Matty A. S.
   Verhoeff, Arnoud P.
   Kupka, Ralph
   Dekker, Jack
   Beekman, Aartjan T. F.
TI Ethnic differences in the association between cardiovascular risk
   factors and psychological distress in a population study in the
   Netherlands
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Obesity; Cardiovascular; Depression; Ethnicity; Epidemiology
ID MAJOR DEPRESSIVE DISORDER; METABOLIC SYNDROME; SCREENING SCALES; NATIVE
   DUTCH; FOLLOW-UP; OBESITY; ANXIETY; SYMPTOMS; TURKISH; HEALTH
AB Background: There is growing body of evidence of an association between cardiovascular risk factors and depressive and anxiety symptoms. The purpose of this study was to investigate whether these associations are similar in ethnic minority groups.
   Methods: A random urban population sample, aged 18+, stratified by ethnicity (484 native Dutch subjects, 383 Turkish-Dutch subjects, and 316 Moroccan-Dutch subjects), in Amsterdam, the Netherlands, was interviewed with the Kessler Psychological Distress scale (K10) in combination with measurements of several cardiovascular risk factors. The association of psychological distress (defined as a K10 score above cut-off of 20) with cardiovascular risk factors (obesity, abdominal obesity, hypertension, hypercholesterolemia, low HDL cholesterol levels or diabetes), ethnicity and their interaction was analyzed using logistic regression analyses, stratified by gender and adjusted for age.
   Results: Cardiovascular risk factors were not significantly associated with psychological distress in any of the gender/ethnic groups, with the exception of a positive association of obesity and hypertension with psychological distress in native Dutch women and a negative association of hypertension and psychological distress in Turkish men. Interaction terms of cardiovascular risk factors and ethnicity were approaching significance only in the association of obesity with the K10 in women.
   Conclusion: In this cross-sectional multi-ethnic adult population sample the majority of the investigated cardiovascular risk factors were not associated with psychological distress. The association of obesity with psychological distress varies by gender and ethnicity. Our findings indicate that the prevention of obesity and psychological distress calls for an integrated approach in native Dutch women, but not necessarily in Turkish-Dutch and Moroccan-Dutch women, in whom these problems may be targeted separately.
C1 [Schrier, Agnes C.; Kupka, Ralph] Altrecht Inst Mental Hlth Care, Utrecht, Netherlands.
   [Ujcic-Voortman, Joanne K.; de Wit, Matty A. S.; Verhoeff, Arnoud P.] Publ Hlth Serv Amsterdam, Dept Epidemiol, Amsterdam, Netherlands.
   [Verhoeff, Arnoud P.] Univ Amsterdam, Dept Sociol & Anthropol, Amsterdam, Netherlands.
   [Kupka, Ralph; Beekman, Aartjan T. F.] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Amsterdam, Netherlands.
   [Dekker, Jack] Vrije Univ Amsterdam, Med Ctr, Dept Clin Psychol, Amsterdam, Netherlands.
   [Dekker, Jack; Beekman, Aartjan T. F.] Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
C3 Public Health Service Amsterdam; University of Amsterdam; Vrije
   Universiteit Amsterdam; Vrije Universiteit Amsterdam; Vrije Universiteit
   Amsterdam
RP Schrier, AC (corresponding author), Altrecht Inst Mental Hlth Care, Utrecht, Netherlands.
EM a.schrier@altrecht.nl
RI Beekman, Aartjan T./LUZ-6919-2024; Verhoeff, Arnoud/F-7924-2013; Kupka,
   Ralph/HDM-4184-2022
OI Kupka, Ralph/0000-0002-1662-7436
FU Municipality of Amsterdam; National Institute of Public Health;
   Environment in the Netherlands; Public Health Service Amsterdam;
   Altrecht Institute for Mental Health
FX The data collection of the study was financed by the Municipality of
   Amsterdam and the National Institute of Public Health and the
   Environment in the Netherlands. The data analyses built on the work of
   Mrs. Joanne Ujcic-Voortman, who is financed by the Public Health Service
   Amsterdam. Mrs. A. C. Schrier was supported by Altrecht Institute for
   Mental Health during data analysis and writing of the manuscript.
CR Agyemang C, 2006, J HYPERTENS, V24, P2169, DOI 10.1097/01.hjh.0000249693.73618.c9
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Alonso J, 2004, INT J METH PSYCH RES, V18, P159
   Andrews G, 2001, AUST NZ J PUBL HEAL, V25, P494, DOI 10.1111/j.1467-842X.2001.tb00310.x
   Beydoun MA, 2010, J AFFECT DISORDERS, V123, P52, DOI 10.1016/j.jad.2009.09.021
   Carpenter KM, 2000, AM J PUBLIC HEALTH, V90, P251, DOI 10.2105/AJPH.90.2.251
   CBO Dutch Institute for Healthcare Improvement, 2006, DUTCH GUID CARD RISK
   de Wit L, 2010, PSYCHIAT RES, V178, P230, DOI 10.1016/j.psychres.2009.04.015
   de Wit MAS, 2008, SOC PSYCH PSYCH EPID, V43, P905, DOI 10.1007/s00127-008-0382-5
   Delaney JAC, 2010, HYPERTENSION, V55, P408, DOI 10.1161/HYPERTENSIONAHA.109.139824
   Donker T, 2010, PSYCHIAT RES, V176, P45, DOI 10.1016/j.psychres.2009.01.012
   Dortland AKBV, 2010, ACTA PSYCHIAT SCAND, V122, P30, DOI 10.1111/j.1600-0447.2010.01565.x
   Dortland AKBV, 2010, J CLIN PSYCHIAT, V71, P729, DOI 10.4088/JCP.08m04865blu
   Fassaert T, 2009, INT J METH PSYCH RES, V18, P159, DOI 10.1002/mpr.288
   Gavin AR, 2010, PUBLIC HEALTH REP, V125, P698, DOI 10.1177/003335491012500512
   Grabe S, 2006, PSYCHOL BULL, V132, P622, DOI 10.1037/0033-2909.132.4.622
   Heo M, 2006, INT J OBESITY, V30, P513, DOI 10.1038/sj.ijo.0803122
   Hildrum B, 2009, ACTA PSYCHIAT SCAND, V120, P14, DOI 10.1111/j.1600-0447.2008.01315.x
   Jackson JS, 2010, AM J PUBLIC HEALTH, V100, P933, DOI 10.2105/AJPH.2008.143446
   Kessler RC, 2002, PSYCHOL MED, V32, P959, DOI 10.1017/S0033291702006074
   Keyes KM, 2011, SOC SCI MED, V72, P650, DOI 10.1016/j.socscimed.2010.12.005
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178, DOI 10.4088/JCP.v69n0202
   Levecque K, 2007, J AFFECT DISORDERS, V97, P229, DOI 10.1016/j.jad.2006.06.022
   Luppino FS, 2011, PSYCHOSOM MED, V73, P257, DOI 10.1097/PSY.0b013e31820a59c0
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Marijnissen RM, 2011, J AM GERIATR SOC, V59, P67, DOI 10.1111/j.1532-5415.2010.03228.x
   Nicolaou M, 2008, PUBLIC HEALTH NUTR, V11, P1332, DOI 10.1017/S1368980008002966
   Ozmen D, 2007, BMC PUBLIC HEALTH, V7, DOI 10.1186/1471-2458-7-80
   Simon GE, 2006, ARCH GEN PSYCHIAT, V63, P824, DOI 10.1001/archpsyc.63.7.824
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Slot J, 2006, MEASUREMENT ACTUAL Q
   Tedders SH, 2011, J AFFECT DISORDERS, V135, P115, DOI 10.1016/j.jad.2011.06.045
   Toker S, 2008, DEPRESS ANXIETY, V25, P661, DOI 10.1002/da.20379
   Ujcic-Voortman JK, 2011, OBESITY FACTS, V4, P53, DOI 10.1159/000324555
   Ujcic-Voortman JK, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-740
   Ujcic-Voortman JK, 2009, EUR J PUBLIC HEALTH, V19, P511, DOI 10.1093/eurpub/ckp096
   Vogelzangs N, 2007, J GERONTOL A-BIOL, V62, P563, DOI 10.1093/gerona/62.5.563
   Vogelzangs N, 2010, J CLIN PSYCHIAT, V71, P391, DOI 10.4088/JCP.08m04743blu
   Vogelzangs N, 2008, ARCH GEN PSYCHIAT, V65, P1386, DOI 10.1001/archpsyc.65.12.1386
   World Health Organization, 2000, 903 WHO
NR 41
TC 2
Z9 3
U1 1
U2 12
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD DEC 18
PY 2012
VL 12
AR 1090
DI 10.1186/1471-2458-12-1090
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 077OB
UT WOS:000314035900001
PM 23249268
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Burgueño, AL
   Juarez, YR
   Genaro, AM
   Tellechea, ML
AF Burgueno, Adriana L.
   Juarez, Yamila R.
   Genaro, Ana M.
   Tellechea, Mariana L.
TI Systematic review and meta-analysis on the relationship between prenatal
   stress and metabolic syndrome intermediate phenotypes
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Review
ID BODY-MASS INDEX; PARENTAL PSYCHOLOGICAL DISTRESS; MATERNAL STRESS;
   WEIGHT-GAIN; DEHYDROGENASE TYPE-2; PSYCHOSOCIAL STRESS; PERINATAL
   OUTCOMES; BLOOD-PRESSURE; TRAFFIC NOISE; EARLY GROWTH
AB Background Metabolic Syndrome (MetS) can be considered as a consequence of a complex interplay between genetic and environmental factors and can be influenced by changes in the environment early in life. Prenatal stress (PS) exposure likely represents an important adverse intrauterine environment that may impact the biology of the developing organism. The aim of this study was to quantitatively synthesize the available data on the effects of PS on offspring's obesity, estimated indirectly by body mass index (BMI) and body fat; blood pressure, plasma glucose and blood lipid concentrations (triglycerides and high-density lipoprotein cholesterol). Methods Literature searches for eligible studies on PubMed were conducted until October 8, 2018. Full text review yielded 24 publications for inclusion into the systematic review. Meta-analyses were performed for the outcomes BMI and body fat. 62 effect sizes from 19 studies together with relevant moderators were collected. Summary estimates were calculated by using random-effects model. Results The combined standardized mean difference (d) for the relation between BMI and PS indicated that despite significant heterogeneity, stress exposure of expectant mothers was associated with increased BMI of their offspring [d (95% CI) = 0.268 (0.191; 0.345)]. Both objective and subjective stress have been linked to increased overweight. Preliminary results of the relationship between PS and body fat suggested that the contribution of PS to body fat should be at least further considered [d (95% CI) = 0.167 (0.016; 0.317)]. Evidence from a limited number of published studies do not sustains an effect on blood pressure, glucose metabolism or circulating lipids, however these outcomes have only been scarcely investigated. Conclusions A direct association between PS and BMI was found and further studies are needed to confirm the relationship between maternal stress during gestation and body fat. Overall, findings suggest that PS could contribute to alterations to the post-natal offspring phenotype.
C1 [Burgueno, Adriana L.; Juarez, Yamila R.; Genaro, Ana M.] Pontificia Univ Catolica Argentina, Consejo Nacl Invest Cient & Tecn CONICET, Inst Invest Biomed, Alicia Moreau de Justo 1600,C1107AFF, Buenos Aires, DF, Argentina.
   [Tellechea, Mariana L.] Hosp Ninos Dr Ricardo Gutierrez, Consejo Nacl Invest Cient & Tecn, Ctr Invest Endocrinol Dr Cesar Bergada, Fdn Endocrinol Infantil,Div Endocrinol, Gallo 1330,C1425EFD, Buenos Aires, DF, Argentina.
C3 Pontificia Universidad Catolica Argentina; Consejo Nacional de
   Investigaciones Cientificas y Tecnicas (CONICET); University of Buenos
   Aires; University of Buenos Aires Hospital; Consejo Nacional de
   Investigaciones Cientificas y Tecnicas (CONICET); Hospital de Ninos
   Doctor Ricardo Gutierrez
RP Tellechea, ML (corresponding author), Hosp Ninos Dr Ricardo Gutierrez, Consejo Nacl Invest Cient & Tecn, Ctr Invest Endocrinol Dr Cesar Bergada, Fdn Endocrinol Infantil,Div Endocrinol, Gallo 1330,C1425EFD, Buenos Aires, DF, Argentina.
EM mtellechea@cedie.org.ar
RI TELLECHEA, MARIANA/AAM-6673-2021
OI Genaro, Ana/0000-0003-0027-3503; TELLECHEA, MARIANA
   LORENA/0000-0002-1194-8433; Burgueno, Adriana L./0000-0001-7584-7044
FU Agencia Nacional de Promocion Cientifica Tecnologica [PICT-2015-1567,
   PICT 2016-2727]; PIP 2015-2017 (Consejo Nacional de Investigaciones
   Cientificas y Tecnicas) [11220150100163]
FX This study was partially supported by grants PICT-2015-1567, PICT
   2016-2727 (Agencia Nacional de Promocion Cientifica Tecnologica) and PIP
   2015-2017 No. 11220150100163 (Consejo Nacional de Investigaciones
   Cientificas y Tecnicas). ALB, AMG, and MLT are members of Consejo
   Nacional de Investigaciones Cientificas y Tecnicas.
CR Aaltonen KJ, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0030275, 10.1371/journal.pone.0043508]
   Alder J, 2007, J MATERN-FETAL NEO M, V20, P189, DOI 10.1080/14767050701209560
   [Anonymous], PLOS ONE
   [Anonymous], PEDIATRICS
   BARKER DJP, 1993, DIABETOLOGIA, V36, P62, DOI 10.1007/BF00399095
   BARKER DJP, 1995, BRIT MED J, V311, P171, DOI 10.1136/bmj.311.6998.171
   BENEDIKTSSON R, 1993, LANCET, V341, P339, DOI 10.1016/0140-6736(93)90138-7
   Bercovich E, 2014, ISR MED ASSOC J, V16, P203
   Bhat SK, 2015, J HYPERTENS, V33, P711, DOI 10.1097/HJH.0000000000000476
   Brown RW, 1996, ENDOCRINOLOGY, V137, P794, DOI 10.1210/en.137.2.794
   Cao-Lei L, 2020, NEUROSCI BIOBEHAV R, V117, P198, DOI 10.1016/j.neubiorev.2017.05.016
   Chatterjee A, 2018, SLEEP HEALTH, V4, P397, DOI 10.1016/j.sleh.2018.07.013
   Christensen JS, 2016, ENVIRON INT, V94, P170, DOI 10.1016/j.envint.2016.05.016
   Christian LM, 2009, BRAIN BEHAV IMMUN, V23, P750, DOI 10.1016/j.bbi.2009.02.012
   Chrousos GP, 2009, NAT REV ENDOCRINOL, V5, P374, DOI 10.1038/nrendo.2009.106
   Danaei G, 2011, LANCET, V378, P31, DOI 10.1016/S0140-6736(11)60679-X
   Dancause KN, 2015, J OBES, V2015, DOI 10.1155/2015/570541
   Dancause KN, 2013, EARLY HUM DEV, V89, P773, DOI 10.1016/j.earlhumdev.2013.06.006
   Davis EP, 2006, INFANT YOUNG CHILD, V19, P246, DOI 10.1097/00001163-200607000-00008
   Deng GJ, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000013262
   Dixon B, 2012, J DEV ORIG HLTH DIS, V3, P433, DOI 10.1017/S2040174412000384
   Drake AJ, 2011, EPIGENETICS-US, V6, P1334, DOI 10.4161/epi.6.11.17942
   EDWARDS CRW, 1993, LANCET, V341, P355, DOI 10.1016/0140-6736(93)90148-A
   Entringer S, 2013, CURR OPIN CLIN NUTR, V16, P320, DOI 10.1097/MCO.0b013e32835e8d80
   Entringer S, 2011, P NATL ACAD SCI USA, V108, pE513, DOI 10.1073/pnas.1107759108
   Entringer S, 2008, AM J OBSTET GYNECOL, V199, DOI 10.1016/j.ajog.2008.03.006
   Farewell CV, 2018, AM J HUM BIOL, V30, DOI 10.1002/ajhb.23116
   Flory JD, 2011, DIS MARKERS, V30, P133, DOI [10.1155/2011/250470, 10.3233/DMA-2011-0748]
   Gitau R, 1998, LANCET, V352, P707, DOI 10.1016/S0140-6736(05)60824-0
   Glover V, 2018, DEV PSYCHOPATHOL, V30, P843, DOI 10.1017/S095457941800038X
   Guxens M, 2013, AM J EPIDEMIOL, V177, P538, DOI 10.1093/aje/kws275
   Harris A, 2011, HORM BEHAV, V59, P279, DOI 10.1016/j.yhbeh.2010.06.007
   Higgins JPT, 2003, BMJ-BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557
   Hohwü L, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0119138
   Hohwü L, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0097490
   Ingstrup KG, 2012, J OBES, V2012, DOI 10.1155/2012/462845
   Jayedi A, 2018, OBES REV, V19, P654, DOI 10.1111/obr.12656
   Ji CP, 2017, ARTHRIT CARE RES, V69, P703, DOI 10.1002/acr.22973
   Kivimäki M, 2018, NAT REV CARDIOL, V15, P215, DOI 10.1038/nrcardio.2017.189
   Li JO, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011896
   Littleton HL, 2007, AM J OBSTET GYNECOL, V196, P424, DOI 10.1016/j.ajog.2007.03.042
   Littleton HL, 2010, J PSYCHOSOM OBST GYN, V31, P219, DOI 10.3109/0167482X.2010.518776
   Liu GT, 2016, ENVIRON RES, V150, P1, DOI 10.1016/j.envres.2016.04.039
   McTernan CL, 2001, J CLIN ENDOCR METAB, V86, P4979, DOI 10.1210/jc.86.10.4979
   Meaney MJ, 2007, TRENDS MOL MED, V13, P269, DOI 10.1016/j.molmed.2007.05.003
   Mirzababaei A, 2019, ENDOCRINE, V63, P439, DOI 10.1007/s12020-019-01840-0
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Ozanne Susan E, 2002, Expert Rev Mol Med, V4, P1, DOI 10.1017/S1462399402005240
   Painter RC, 2006, J HYPERTENS, V24, P1771, DOI 10.1097/01.hjh.0000242401.45591.e7
   PHILLIPS DIW, 1994, DIABETOLOGIA, V37, P150, DOI 10.1007/s001250050086
   Reynolds RM, 2010, J STEROID BIOCHEM, V122, P3, DOI 10.1016/j.jsbmb.2010.01.009
   Roseboom T, 2006, EARLY HUM DEV, V82, P485, DOI 10.1016/j.earlhumdev.2006.07.001
   Singhal A, 2004, CIRCULATION, V109, P1108, DOI 10.1161/01.CIR.0000118500.23649.DF
   Stettler N, 2002, PEDIATRICS, V109, P194, DOI 10.1542/peds.109.2.194
   Stettler N, 2005, CIRCULATION, V111, P1897, DOI 10.1161/01.CIR.0000161797.67671.A7
   Stroup DF, 2000, JAMA-J AM MED ASSOC, V283, P2008, DOI 10.1001/jama.283.15.2008
   Taal HR, 2013, EARLY HUM DEV, V89, P547, DOI 10.1016/j.earlhumdev.2013.01.005
   Tate EB, 2015, OBES REV, V16, P351, DOI 10.1111/obr.12262
   Tellechea ML, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-05344-7
   van Dijk AE, 2014, J DEV ORIG HLTH DIS, V5, P361, DOI 10.1017/S2040174414000300
   Van Dijk AE, 2012, EARLY HUM DEV, V88, P351, DOI 10.1016/j.earlhumdev.2011.09.009
   van Dijk AE, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043548
   van Montfoort N, 2005, EUR J ENDOCRINOL, V153, P811, DOI 10.1530/eje.1.02050
   Wang R, 2017, FRONT PSYCHIATRY, V8, DOI 10.3389/fpsyt.2017.00208
   Wells JCK, 2003, J THEOR BIOL, V221, P143, DOI 10.1006/jtbi.2003.3183
   Weyde KV, 2018, EPIDEMIOLOGY, V29, P729, DOI [10.1097/EDE.0000000000000868, 10.1097/ede.0000000000000868]
   Wu SW, 2018, PSYCHOSOM MED, V80, P34, DOI 10.1097/PSY.0000000000000517
   Zadzinska E, 2013, ANN HUM BIOL, V40, P477, DOI 10.3109/03014460.2013.806589
NR 68
TC 17
Z9 17
U1 0
U2 8
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD JAN
PY 2020
VL 44
IS 1
BP 1
EP 12
DI 10.1038/s41366-019-0423-z
PG 12
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA KH0JR
UT WOS:000510334700001
PM 31332277
DA 2025-06-11
ER

PT J
AU Rani, R
   Nain, S
   Paliwal, S
AF Rani, Rashmi
   Nain, Sumitra
   Paliwal, Sarvesh
TI A Review on Pharmacological Potential of Medicago sativa Linn.
SO CURRENT TRADITIONAL MEDICINE
LA English
DT Review
DE Medicago sativa; alfalfa; extract; medicinal plant; chemical
   constituents; pharmacological uses; diseases
ID ANTIOXIDANT ACTIVITY; AQUEOUS EXTRACT; IN-VITRO; ALFALFA; L.;
   CYTOTOXICITY; SEEDS
AB Background: Medicago sativa Linn. in Hindi, is called lasunghas, and in English, it is called alfalfa. It is a well-known crop of the Fabaceae family. Anyone can eat its sprouts as a salad vegetable. This plant has a wide range of uses as a feed crop and is tolerant to climate change. Objective: In this review, the authors discussed the active chemical constituents and pharmacological uses of Medicago sativa Linn. in various diseases. Methods: To compile this review, information is collected the research papers from different databases like Taylor & Francis, ResearchGate, Elsevier, PubMed, Wiley Online Library, and PMC. Results Alfalfa has been shown to be an important origin of phytochemicals like amino acids, coumarins, alkaloids, carotenes, flavonoids, organic acids, digestive enzymes, phytosterols, saponins, phytoestrogens, phenolic compounds, polyamines, and a few other volatile organic compounds like ketones, terpenes, alcohols and furanoids. This plant is useful in CNS disorders, anxiety, oxidative stress, hepatotoxicity, inflammation, cancer, atherosclerosis, diabetes, burn wounds, vitiligo, reproductive system, myocardial infraction, bacteria, xanthine oxidase and metabolic syndrome. Conclusion: This review may be helpful in knowing of Medicago sativa Linn. with greater therapeutic potential for treatment of various diseases.
C1 [Rani, Rashmi; Nain, Sumitra; Paliwal, Sarvesh] Banasthali Vidyapith, Dept Pharm, Newai, Rajasthan, India.
C3 Banasthali Vidyapith
RP Nain, S (corresponding author), Banasthali Vidyapith, Dept Pharm, Newai, Rajasthan, India.
EM nainsumitra@gmail.com
RI Nain, Sumitra/R-8987-2019
OI Nain, Dr. Sumitra/0000-0001-8238-3145
FX The authors are thankful to the Honorable Vice-Chancellor of Banasthali
   Vidyapith Rajasthan for providing the essential facilities.
CR Abdo S., 2014, Pharmacol, V2, P1
   Adaay M H., 2013, Journal of Materials and Environmental Science, V4, P424
   Al-Dosari MS, 2012, AM J CHINESE MED, V40, P779, DOI 10.1142/S0192415X12500589
   Al-Snafi AE., 2021, Int J Biol Pharm. Sci Arch, V1, P022, DOI [10.30574/ijbpsa.2021.1.2.0302, DOI 10.30574/IJBPSA.2021.1.2.0302]
   Amraie E, 2015, INTERV MED APPL SCI, V7, P124, DOI 10.1556/1646.7.2015.3.7
   Bharti A., 2013, A review: Plants and herbs used in anxiety
   Bora K. S., 2010, Journal of Pharmacy Research, V3, P1206
   Bora KS, 2012, PHARM BIOL, V50, P878, DOI 10.3109/13880209.2011.641227
   Bora KS, 2011, EVID-BASED COMPL ALT, V2011, P1, DOI 10.1093/ecam/neq019
   Bora KS, 2011, PHARM BIOL, V49, P211, DOI 10.3109/13880209.2010.504732
   Boué SM, 2003, J AGR FOOD CHEM, V51, P2193, DOI 10.1021/jf021114s
   Choi KC, 2013, J MED FOOD, V16, P410, DOI 10.1089/jmf.2012.2679
   Dixit V P, 1990, Anc Sci Life, V10, P52
   Doss A., 2011, INDIAN J SCI TECHNOL, V4, P550
   Ehsan Karimi Ehsan Karimi, 2013, Journal of Medicinal Plants Research, V7, P290
   Gatouillat G, 2014, NUTR CANCER, V66, P483, DOI 10.1080/01635581.2014.884228
   Gomathi R., 2014, Int. J. Pharm. Pharm. Sci, P839
   Hettle J.A., 1984, Anim. Reprod. Sci, P233
   Hong YH, 2009, J BIOMED SCI, V16, DOI 10.1186/1423-0127-16-64
   Inostroza L, 2021, PLANTS-BASEL, V10, DOI 10.3390/plants10050862
   Jadhav R., 2015, medicine (Baltimore)
   Joy G.S., 2014, IJPDA, V2, P65
   Khalaf SJ, 2021, PAK J MED HEALTH SCI, V15, P492
   Khaleel AE, 2005, J FOOD DRUG ANAL, V13, P212
   Khayatzadeh J., 2009, J. Arak Univ. Med. Sci, V12, P29
   Liu XG, 2019, J FOOD BIOCHEM, V43, DOI 10.1111/jfbc.12955
   Martínez R, 2016, J FUNCT FOODS, V26, P470, DOI 10.1016/j.jff.2016.08.013
   Mirzaei Ali, 2015, Glob J Health Sci, V7, P137, DOI 10.5539/gjhs.v7n7p137
   MOLGAARD J, 1987, ATHEROSCLEROSIS, V65, P173, DOI 10.1016/0021-9150(87)90019-0
   MONTANARO A, 1991, RHEUM DIS CLIN N AM, V17, P323
   Pinzaru I, 2018, REV CHIM-BUCHAREST, V69, P121
   Raeeszadeh M, 2021, EVID-BASED COMPL ALT, V2021, DOI [10.1155/2021/8388002, 10.1155/2021/6694629]
   Rana M.G., 2010, ROM J BIOL PLANT BIO, V55, P15
   RUBENSTEIN AH, 1962, NATURE, V194, P188, DOI 10.1038/194188a0
   Salih B.A., 2019, Polytechnic Journal, V9, P23, DOI [DOI 10.25156/PTJ.V9N1Y2019.PP23-25, 10.25156/ptj.v9n1y2019.pp23-25]
   Sargazi A., 2016, Der Pharmacia Lettre, V8, P351
   Seddighfar M, 2020, J INTEGR MED-JIM, V18, P181, DOI 10.1016/j.joim.2020.02.003
   Seida A, 2015, PAK J PHARM SCI, V28, P2061
   Selvan A.T., 2014, Indo American J Pharma Res, V4, P406
   Suwignyo B, 2021, VET WORLD, V14, P2719, DOI 10.14202/vetworld.2021.2719-2726
   SWANSTONFLATT SK, 1990, DIABETOLOGIA, V33, P462, DOI 10.1007/BF00405106
   Wang SP, 2013, INT J BIOL MACROMOL, V62, P387, DOI 10.1016/j.ijbiomac.2013.09.029
   WHITE RD, 1983, TOXICOL LETT, V15, P25, DOI 10.1016/0378-4274(83)90164-9
   Yamura S., 1978, Fol Pharmacol Jap, V71, P27
   Zadeh M. Z., 2014, World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS), V3, P910
   Zagórska-Dziok M, 2020, BIORESEARCH OPEN ACC, V9, P229, DOI 10.1089/biores.2020.0015
NR 46
TC 1
Z9 1
U1 4
U2 5
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 2215-0838
EI 2215-0846
J9 CURR TRADIT MED
JI Curr. Tradit. Med.
PY 2024
VL 10
IS 7
AR e070923220781
DI 10.2174/2215083810666230907093431
PG 7
WC Integrative & Complementary Medicine
WE Emerging Sources Citation Index (ESCI)
SC Integrative & Complementary Medicine
GA E9S5Q
UT WOS:001306328500006
DA 2025-06-11
ER

PT J
AU Yu, BN
   Cook, C
   Santanam, N
AF Yu, Bangning
   Cook, Carla
   Santanam, Nalini
TI The Aporphine Alkaloid Boldine Induces Adiponectin Expression and
   Regulation in 3T3-L1 Cells
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Article
DE adipogenesis; antioxidant; oxidative stress; peroxisome
   proliferator-activated receptors
ID OXIDATIVE STRESS; OXIDATIVE/NITRATIVE STRESS; ADIPOCYTE DIFFERENTIATION;
   INSULIN SENSITIVITY; GENE-TRANSCRIPTION; LIPID-PEROXIDATION; METABOLIC
   SYNDROME; SIGNALING PATHWAY; ADIPOSE-TISSUE; DIABETIC-RATS
AB Adiponectin is an adipokine secreted by differentiated adipocytes. Clinical studies suggest a negative correlation between oxidative stress and adiponectin levels in patients with metabolic syndrome or cardiovascular disease. Natural compounds that can prevent oxidative stress mediated inhibition of adiponectin may be potentially therapeutic. Boldine, an aporphine alkaloid abundant in the medicinal plant Peumus boldus, is a powerful antioxidant. The current study demonstrates the effects of boldine on the expression of adiponectin and its regulators, CCAAT/enhancer binding protein-alpha (C/EBP Chi) and peroxisome proliferator-activated receptor (PPAR)-gamma, in 3T3-L1 cells. Differentiated 3T3-L1 adipocytes were exposed to either hydrogen peroxide (H2O2) (100 mu M) or tumor necrosis factor-alpha (TNF alpha) (1 ng/mL) for 24 hours in the presence or absence of increasing concentrations of boldine (5-100 mu M). Quantitative polymerase chain reaction showed that both the oxidants decreased the mRNA levels of adiponectin, PPAR gamma, and C/EBP alpha to half of the control levels. Boldine, at all concentrations, counteracted the inhibitory effect of H2O2 or TNFa and increased the expression of adiponectin and its regulators. The effect of boldine on adiponectin expression was biphasic, with the lower concentrations (5-25 mu M) having a larger inductive effect compared to higher concentrations (50-100 mu M). Boldine treatment alone in the absence of H2O2 or TNF alpha was also able to induce adiponectin at the inductive phase of adipogenesis. Peroxisome proliferator response element-luciferase promoter transactivity analysis showed that boldine interacts with the PPAR response element and could potentially modulate PPAR responsive genes. Our results indicate that boldine is able to modulate the expression of adiponectin and its regulators in 3T3-L1 cells and has the potential to be beneficial in obesity-related cardiovascular disease.
C1 [Cook, Carla; Santanam, Nalini] Marshall Univ, Dept Pharmacol Physiol & Toxicol, Joan C Edwards Sch Med, Huntington, WV 25755 USA.
   [Yu, Bangning] Louisiana State Univ, Hlth Sci Ctr, Dept Pharmacol, New Orleans, LA USA.
C3 Marshall University; Louisiana State University System; Louisiana State
   University Health Sciences Center New Orleans
RP Santanam, N (corresponding author), Marshall Univ, Dept Pharmacol Physiol & Toxicol, Joan C Edwards Sch Med, 1 John Marshall Dr, Huntington, WV 25755 USA.
EM santanam@marshall.edu
OI Santanam, Nalini/0000-0003-3343-6081
FU National Institutes of Health [HL074239, 5P20RR016477]
FX The authors acknowledge support from grants HL074239 (to N.S.) and
   5P20RR016477 from the National Institutes of Health. The authors thank
   Dr. Gary Rankin, Ms. Amy Deborde, and Dr. Elsa Mangiarua for their help
   with proofreading our manuscript.
CR BACKHOUSE N, 1994, AGENTS ACTIONS, V42, P114, DOI 10.1007/BF01983475
   Brun RP, 1996, CURR OPIN CELL BIOL, V8, P826, DOI 10.1016/S0955-0674(96)80084-6
   Chen BY, 2006, BIOCHEM BIOPH RES CO, V341, P549, DOI 10.1016/j.bbrc.2006.01.004
   Chi TC, 2006, PLANTA MED, V72, P1175, DOI 10.1055/s-2006-947199
   Cho KJ, 2003, J BIOL CHEM, V278, P34823, DOI 10.1074/jbc.M210747200
   Cho SY, 2007, AM J PHYSIOL-ENDOC M, V292, pE1166, DOI 10.1152/ajpendo.00436.2006
   Fantuzzi G, 2008, J ALLERGY CLIN IMMUN, V121, P326, DOI 10.1016/j.jaci.2007.10.018
   Farmer SR, 2005, INT J OBESITY, V29, pS13, DOI 10.1038/sj.ijo.0802907
   Ferroni Patrizia, 2004, Curr Atheroscler Rep, V6, P424, DOI 10.1007/s11883-004-0082-x
   Fox KE, 2006, J BIOL CHEM, V281, P40341, DOI 10.1074/jbc.M605077200
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Giannessi D, 2007, PHARMACOL RES, V56, P459, DOI 10.1016/j.phrs.2007.09.014
   Gong HX, 2004, EUR J ENDOCRINOL, V150, P885, DOI 10.1530/eje.0.1500885
   Hattori Y, 2005, DIABETOLOGIA, V48, P1066, DOI 10.1007/s00125-005-1766-7
   Hiuge A, 2007, ARTERIOSCL THROM VAS, V27, P635, DOI 10.1161/01.ATV.0000256469.06782.d5
   Hsu CL, 2007, J AGR FOOD CHEM, V55, P8404, DOI 10.1021/jf071695r
   Hu E, 1996, J BIOL CHEM, V271, P10697, DOI 10.1074/jbc.271.18.10697
   Iwata C, 2007, LIFE SCI, V80, P873, DOI 10.1016/j.lfs.2006.11.012
   James WPT, 2008, J INTERN MED, V263, P336, DOI 10.1111/j.1365-2796.2008.01922.x
   Jang YY, 2000, PHARMACOL RES, V42, P361, DOI 10.1006/phrs.2000.0705
   Jiménez I, 2000, ARCH BIOCHEM BIOPHYS, V381, P247, DOI 10.1006/abbi.2000.1963
   Jiménez I, 2000, PHYTOTHER RES, V14, P339, DOI 10.1002/1099-1573(200008)14:5<339::AID-PTR585>3.0.CO;2-T
   Kamigaki M, 2006, BIOCHEM BIOPH RES CO, V339, P624, DOI 10.1016/j.bbrc.2005.11.059
   Kita A, 2005, BIOCHEM BIOPH RES CO, V331, P484, DOI 10.1016/j.bbrc.2005.03.205
   Konrath EL, 2008, NEUROTOXICOLOGY, V29, P1136, DOI 10.1016/j.neuro.2008.05.008
   KRINGSTEIN P, 1995, FREE RADICAL BIO MED, V18, P559, DOI 10.1016/0891-5849(94)E0138-9
   Kubínová R, 2001, PHARMAZIE, V56, P242
   Lane Geoffrey, 2008, Menopause Int, V14, P33, DOI 10.1258/mi.2007.007036
   LANHERS MC, 1991, PLANTA MED, V57, P110, DOI 10.1055/s-2006-960043
   Lara-Castro C, 2007, CURR OPIN LIPIDOL, V18, P263, DOI 10.1097/MOL.0b013e32814a645f
   Li R, 2007, AM J PHYSIOL-ENDOC M, V293, pE1703, DOI 10.1152/ajpendo.00462.2007
   Lin J, 2005, OBES RES, V13, P982, DOI 10.1038/oby.2005.115
   Lu JY, 2008, J BIOMED SCI, V15, P565, DOI 10.1007/s11373-008-9261-z
   Magalang UJ, 2006, ANTIOXID REDOX SIGN, V8, P2179, DOI 10.1089/ars.2006.8.2179
   Mao XM, 2006, MINI-REV MED CHEM, V6, P1331, DOI 10.2174/138955706778992978
   Milián L, 2004, CHEM PHARM BULL, V52, P696, DOI 10.1248/cpb.52.696
   Mineo H, 2007, CELL BIOL INT, V31, P703, DOI 10.1016/j.cellbi.2007.01.002
   Moller DE, 2003, INT J OBESITY, V27, pS17, DOI 10.1038/sj.ijo.0802494
   O'Brien P, 2006, CHEM-BIOL INTERACT, V159, P1, DOI 10.1016/j.cbi.2005.09.002
   Ouchi N, 2007, CLIN CHIM ACTA, V380, P24, DOI 10.1016/j.cca.2007.01.026
   Ouedraogo R, 2006, DIABETES, V55, P1840, DOI 10.2337/db05-1174
   Pajvani UB, 2004, J BIOL CHEM, V279, P12152, DOI 10.1074/jbc.M311113200
   Parthasarathy S, 2001, Curr Atheroscler Rep, V3, P392, DOI 10.1007/s11883-001-0077-9
   Pfaffl MW, 2001, NUCLEIC ACIDS RES, V29, DOI 10.1093/nar/29.9.e45
   Pinent M, 2005, INT J OBESITY, V29, P934, DOI 10.1038/sj.ijo.0802988
   Pradhan A, 2007, NUTR REV, V65, pS152, DOI 10.1301/nr.2007.dec.S152-S156
   Qiao LP, 2005, DIABETES, V54, P1744, DOI 10.2337/diabetes.54.6.1744
   Rayalam S, 2007, J NUTR, V137, P2668, DOI 10.1093/jn/137.12.2668
   Salma N, 2006, J MOL ENDOCRINOL, V36, P139, DOI 10.1677/jme.1.01918
   Santanam N, 2004, ATHEROSCLEROSIS, V173, P203, DOI 10.1016/j.atherosclerosis.2003.12.035
   SCHERER PE, 1995, J BIOL CHEM, V270, P26746, DOI 10.1074/jbc.270.45.26746
   Schmeda-Hirschmann G, 2003, FREE RADICAL RES, V37, P447, DOI 10.1080/1071576031000090000
   Sharma AM, 2007, J CLIN ENDOCR METAB, V92, P386, DOI 10.1210/jc.2006-1268
   Sheng TX, 2008, J GENET GENOMICS, V35, P321, DOI 10.1016/S1673-8527(08)60047-8
   Shiniada M, 2007, BIOSCI BIOTECH BIOCH, V71, P2079, DOI 10.1271/bbb.70174
   Soares AF, 2005, FREE RADICAL BIO MED, V38, P882, DOI 10.1016/j.freeradbiomed.2004.12.010
   SPEISKY H, 1991, BIOCHEM PHARMACOL, V41, P1575, DOI 10.1016/0006-2952(91)90156-Y
   SPEISKY H, 1994, PHARMACOL RES, V29, P1, DOI 10.1016/1043-6618(94)80093-6
   Steffes MW, 2006, OBESITY, V14, P319, DOI 10.1038/oby.2006.41
   Stern Naftali, 2007, J Cardiometab Syndr, V2, P174, DOI 10.1111/j.1559-4564.2007.06597.x
   Stevigny C., 2005, Current Medicinal Chemistry - Anti-Cancer Agents, V5, P173, DOI 10.2174/1568011053174864
   Swarbrick Michael M., 2008, Metabolic Syndrome and Related Disorders, V6, P87, DOI 10.1089/met.2007.0029
   Takeuchi Y, 2007, NEMATOLOGY, V9, P243, DOI 10.1163/156854107780739027
   Tao L, 2007, CIRCULATION, V115, P1408, DOI 10.1161/CIRCULATIONAHA.106.666941
   Tarquini R, 2007, INTERN EMERG MED, V2, P165, DOI 10.1007/s11739-007-0027-9
   Traber MG, 2008, CURR OPIN LIPIDOL, V19, P30, DOI 10.1097/MOL.0b013e3282f2dab6
   UBEDA A, 1993, FREE RADICAL BIO MED, V15, P159, DOI 10.1016/0891-5849(93)90055-Y
NR 67
TC 16
Z9 18
U1 0
U2 17
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD OCT
PY 2009
VL 12
IS 5
BP 1074
EP 1083
DI 10.1089/jmf.2008.0230
PG 10
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA 511EE
UT WOS:000271145900020
PM 19857072
OA Green Published
DA 2025-06-11
ER

PT J
AU Kim, YK
   Song, J
AF Kim, Young-Kook
   Song, Juhyun
TI Metabolic imbalance and brain tumors: The interlinking metabolic
   pathways and therapeutic actions of antidiabetic drugs
SO PHARMACOLOGICAL RESEARCH
LA English
DT Article
DE Brain tumor; Metabolic syndrome; Antidiabetic drugs; Diabetes; Obesity
ID TYPE-2 DIABETES-MELLITUS; OXIDATIVE STRESS; ADIPOSE-TISSUE; CANCER-RISK;
   GLIOBLASTOMA; RECEPTOR; TEMOZOLOMIDE; METFORMIN; OBESITY; LEPTIN
AB Brain tumors are complex, heterogeneous malignancies, often associated with significant morbidity and mortality. Emerging evidence suggests the important role of metabolic syndrome, such as that observed in diabetes mellitus, in the progression of brain tumors. Several studies indicated that hyperglycemia, insulin resistance, oxidative stress, and altered adipokine profiles influence tumor growth, proliferation, and treatment resistance. Intriguingly, antidiabetic drugs (e.g., metformin, sulfonylureas, dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists, and thiazolidinediones) have shown promise as adjunctive or repurposed agents in managing brain tumors. Metformin can impair tumor cell proliferation, enhance treatment sensitivity, and modify the tumor microenvironment by activating AMP-activated protein kinase (AMPK) and inhibiting mammalian target of rapamycin (mTOR) signaling pathways. DPP-4 inhibitors and GLP-1 receptor agonists can target both metabolic and inflammatory aspects of brain tumors, while thiazolidinediones may induce apoptosis in tumor cells and synergize with other therapeutics. Consequently, further studies and clinical trials are needed to confirm the efficacy, safety, and utility of metabolic interventions in treating brain tumors. Here, we review the evidence for the metabolic interconnections between metabolic diseases and brain tumors and multiple actions of anti-diabetes drugs in brain tumors.
C1 [Kim, Young-Kook] Chonnam Natl Univ, Med Sch, Dept Biochem, Hwasun 58128, Jeollanam Do, South Korea.
   [Song, Juhyun] Chonnam Natl Univ, Dept Anat, Med Sch, Hwasun 58128, Jeollanam Do, South Korea.
C3 Chonnam National University; Chonnam National University
RP Kim, YK (corresponding author), Chonnam Natl Univ, Med Sch, Dept Biochem, Hwasun 58128, Jeollanam Do, South Korea.; Song, J (corresponding author), Chonnam Natl Univ, Dept Anat, Med Sch, Hwasun 58128, Jeollanam Do, South Korea.
EM ykk@jnu.ac.kr; juhyunsong@chonnam.ac.kr
RI Song, Juhyun/AAH-3162-2020
FU National Research Foundation of Korea (NRF) , Republic of Korea
   [RS-2022-NR069292, RS-2024-00333553, RS-2024-00398786]
FX This study was supported by grants RS-2022-NR069292 (Juhyun Song) ,
   RS-2024-00333553 (Young-Kook Kim) , and RS-2024-00398786 (Young-Kook
   Kim) from the National Research Foundation of Korea (NRF) , Republic of
   Korea.
CR Adeberg S, 2015, STRAHLENTHER ONKOL, V191, P928, DOI 10.1007/s00066-015-0884-5
   Agrawal K, 2023, CANCERS, V15, DOI 10.3390/cancers15204920
   Alarcon S, 2019, MOL ASPECTS MED, V66, P62, DOI 10.1016/j.mam.2019.02.002
   Alexandru Oana, 2014, Curr Health Sci J, V40, P27, DOI 10.12865/CHSJ.40.01.05
   Arcidiacono B, 2012, EXP DIABETES RES, DOI 10.1155/2012/789174
   Badawi A, 2010, DIABETES METAB SYNDR, V3, P173, DOI 10.2147/DMSO.S9089
   Bader JE, 2020, MOL CELL, V78, P1019, DOI 10.1016/j.molcel.2020.05.034
   Barami K, 2017, WORLD NEUROSURG, V106, P300, DOI [10.1016/J.WNEU.2017.06.164, 10.1016/j.wneu.2017.06.164]
   Barnholtz-Sloan JS, 2018, NEUROL CLIN, V36, P395, DOI 10.1016/j.ncl.2018.04.001
   Bartusik-Aebisher D, 2023, BRAIN SCI, V13, DOI 10.3390/brainsci13091299
   Bielecka-Wajdman AM, 2022, CANCER CONTROL, V29, DOI 10.1177/10732748221075468
   Bielen A., Mol. Cancer
   Bifulco M, 2017, J NEURO-ONCOL, V131, P421, DOI 10.1007/s11060-016-2315-6
   Bikis C, 2018, HORM CANCER-US, V9, P144, DOI 10.1007/s12672-018-0327-8
   Black HS, 2024, J MOL PATHOL, V5, P96, DOI 10.3390/jmp5010007
   Booth A, 2015, HORM MOL BIOL CLIN I, V21, P57, DOI 10.1515/hmbci-2014-0037
   Busek P, 2008, PHYSIOL RES, V57, P443, DOI 10.33549/physiolres.931231
   Caturano A, 2023, CURR ISSUES MOL BIOL, V45, P6651, DOI 10.3390/cimb45080420
   Chen W, 2024, SCI REP-UK, V14, DOI 10.1038/s41598-024-67341-x
   Chiarelli F, 2008, VASC HEALTH RISK MAN, V4, P297
   Crist M, 2022, J IMMUNOTHER CANCER, V10, DOI 10.1136/jitc-2022-005632
   de Robles P, 2015, NEURO-ONCOLOGY, V17, P776, DOI 10.1093/neuonc/nou283
   de Vasconcelos A, 2021, MED CHEM, V17, P601, DOI 10.2174/1573406416666200403075826
   Ding WC, 2023, EXP CELL RES, V430, DOI 10.1016/j.yexcr.2023.113691
   Diniz J S, 2000, J Pediatr (Rio J), V76, P383
   Dodson M, 2019, REDOX BIOL, V23, DOI 10.1016/j.redox.2019.101107
   Duraj T, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10020202
   Fuentes-Fayos AC, 2023, EBIOMEDICINE, V90, DOI 10.1016/j.ebiom.2023.104484
   Gatta-Cherifi B, 2024, EUR J ENDOCRINOL, V190, P257, DOI 10.1093/ejendo/lvae024
   Gilbert MP, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00178
   Gjersdal E, 2024, PITUITARY, V27, P723, DOI 10.1007/s11102-024-01426-8
   Gong YY, 2016, NEURO-ONCOLOGY, V18, P48, DOI 10.1093/neuonc/nov096
   Han GS, 2013, CELL CYCLE, V12, P3833, DOI 10.4161/cc.26809
   Hua Y, 2023, J TRANSL MED, V21, DOI 10.1186/s12967-023-04263-8
   Jarabo P, 2021, LIFE SCI ALLIANCE, V4, DOI 10.26508/lsa.202000693
   Jha RM, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222111899
   Johnson DR, 2017, RADIOGRAPHICS, V37, P2164, DOI 10.1148/rg.2017170037
   Kabeya Y, 2015, J EPIDEMIOL, V25, P297, DOI 10.2188/jea.JE20140163
   Kahn SE, 2003, DIABETOLOGIA, V46, P3, DOI 10.1007/s00125-002-1009-0
   Kim EH, 2017, NEURO-ONCOLOGY, V19, P197, DOI 10.1093/neuonc/now174
   Kim JW, 2024, BIOMEDICINES, V12, DOI 10.3390/biomedicines12010097
   Kim Yu Jin, 2021, Alzheimers Dement (N Y), V7, pe12174, DOI 10.1002/trc2.12174
   Kinfe TM, 2020, CANCERS, V12, DOI 10.3390/cancers12123691
   King-Stephens D, 2022, EPILEPSY CURR, V22, P288, DOI 10.1177/15357597221107796
   Kocot J, 2017, MED SCI MONITOR, V23, P4995, DOI 10.12659/MSM.904318
   Komarowska M, 2022, ADV MED SCI-POLAND, V67, P229, DOI 10.1016/j.advms.2022.04.002
   Kuduvalli SS, 2024, TOXICOL APPL PHARM, V493, DOI 10.1016/j.taap.2024.117146
   Lee CH, 2015, CLIN ENDOCRINOL, V83, P147, DOI 10.1111/cen.12667
   Lee H, 2022, SEMIN CANCER BIOL, V86, P347, DOI 10.1016/j.semcancer.2022.07.005
   Lee MW, 2019, J CLIN MED, V8, DOI 10.3390/jcm8060854
   Lelièvre P, 2020, CANCERS, V12, DOI 10.3390/cancers12123524
   León-González AJ, 2021, CURR OPIN PHARMACOL, V60, P17, DOI 10.1016/j.coph.2021.06.002
   Li J, 2012, HAND CLINIC, V104, P23, DOI 10.1016/B978-0-444-52138-5.00002-5
   Liberti MV, 2016, TRENDS BIOCHEM SCI, V41, P211, DOI 10.1016/j.tibs.2015.12.001
   Lichtor T, 2008, PPAR RES, V2008, DOI 10.1155/2008/547470
   Lin HC, 2014, J CLIN PHARM THER, V39, P354, DOI 10.1111/jcpt.12151
   Liu EK, 2022, NEURO-ONCOL ADV, V4, DOI 10.1093/noajnl/vdac163
   Liu HW, 2016, MOL NEUROBIOL, V53, P1654, DOI 10.1007/s12035-015-9115-4
   Luc K, 2019, J PHYSIOL PHARMACOL, V70, P809, DOI 10.26402/jpp.2019.6.01
   Martin KC, 2023, BRAIN SCI, V13, DOI 10.3390/brainsci13050817
   Mazurek M, 2020, CANCERS, V12, DOI 10.3390/cancers12010210
   Mergenthaler P, 2013, TRENDS NEUROSCI, V36, P587, DOI 10.1016/j.tins.2013.07.001
   Mitri J, 2008, DIABETES CARE, V31, P2391, DOI 10.2337/dc08-1034
   Mouhieddine TH, 2015, FRONT NEUROSCI-SWITZ, V9, DOI 10.3389/fnins.2015.00442
   Mousa SA, 2019, NEURAL REGEN RES, V14, P745, DOI 10.4103/1673-5374.249217
   Ng SCW, 2022, ACS OMEGA, V7, P25337, DOI 10.1021/acsomega.2c02285
   Oh KJ, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18010008
   Ohno M, 2022, CANCERS, V14, DOI 10.3390/cancers14174222
   Oreskovic D, 2024, BMC CANCER, V24, DOI 10.1186/s12885-024-12243-4
   Ostrom QT, 2022, NEURO-ONCOLOGY, V24, pv1, DOI 10.1093/neuonc/noac202
   Panhans CM, 2020, FRONT NEUROSCI-SWITZ, V14, DOI 10.3389/fnins.2020.00390
   Pantelidis P, 2019, CLIN NEUROL NEUROSUR, V184, DOI 10.1016/j.clineuro.2019.105450
   Park J, 2011, ENDOCR REV, V32, P550, DOI 10.1210/er.2010-0030
   Pasello G, 2013, ONCOLOGIST, V18, P1118, DOI 10.1634/theoncologist.2013-0177
   Poff A, 2019, SEMIN CANCER BIOL, V56, P135, DOI 10.1016/j.semcancer.2017.12.011
   Pu X, 2021, FRONT ONCOL, V11, DOI 10.3389/fonc.2021.685923
   Qi XC, 2022, MOL CANCER, V21, DOI 10.1186/s12943-022-01668-9
   Ranjan G., 2024, Naunyn Schmiede Arch. Pharm.
   Riolfi M, 2010, BRAIN PATHOL, V20, P481, DOI 10.1111/j.1750-3639.2009.00323.x
   Ronsley R, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-75638-w
   Schiff D, 2015, NEURO-ONCOLOGY, V17, P488, DOI 10.1093/neuonc/nou304
   Schultz H, 2018, NEURO-ONCOL PRACT, V5, P170, DOI 10.1093/nop/npx027
   Schwartz L, 2017, SEMIN CANCER BIOL, V43, P134, DOI 10.1016/j.semcancer.2017.01.005
   Schwartz SS, 2024, BMC MED, V22, DOI 10.1186/s12916-024-03763-8
   Seliger C, 2016, NEURO-ONCOLOGY, V18, P340, DOI 10.1093/neuonc/nov100
   Sergentanis TN, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0136974
   Sesen J, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0123721
   Shah SD, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25115694
   Shi DJ, 2021, CANCER EPIDEMIOL, V73, DOI 10.1016/j.canep.2021.101946
   Song Yang, 2018, Oncotarget, V9, P7023, DOI 10.18632/oncotarget.23317
   Stupp R, 2005, NEW ENGL J MED, V352, P987, DOI 10.1056/NEJMoa043330
   Sun NY, 2020, FRONT ONCOL, V10, DOI 10.3389/fonc.2020.00792
   Sun XY, 2023, BRAIN SCI, V13, DOI 10.3390/brainsci13050786
   Szoka L, 2020, BIOMED PHARMACOTHER, V132, DOI 10.1016/j.biopha.2020.110741
   Takhwifa F, 2021, HELIYON, V7, DOI 10.1016/j.heliyon.2021.e06558
   Tan AC, 2020, CA-CANCER J CLIN, V70, P299, DOI 10.3322/caac.21613
   Tapia-Pérez JH, 2011, CANCER CHEMOTH PHARM, V67, P1193, DOI 10.1007/s00280-010-1535-2
   Thompson EM, 2018, CLIN NEUROPATHOL, V37, P221, DOI 10.5414/NP301102
   Tong JJ, 2012, EXP THER MED, V4, P877, DOI 10.3892/etm.2012.698
   Tsuji S, 2024, BIOCHEM BIOPH RES CO, V711, DOI 10.1016/j.bbrc.2024.149897
   Umar MI, 2021, PATHOL ONCOL RES, V27, DOI 10.3389/pore.2021.1609828
   Ungvari Z, 2025, GEROSCIENCE, DOI 10.1007/s11357-024-01494-5
   Vokuda Ramya S, 2019, Asian Pac J Cancer Prev, V20, P479
   Vujotic L, 2020, ARCH MED SCI, V16, P811, DOI 10.5114/aoms.2019.87409
   Yao B, 2023, CURR ONCOL, V30, P5024, DOI 10.3390/curroncol30050379
   Yin SC, 2010, NEURO-ONCOLOGY, V12, P19, DOI 10.1093/neuonc/nop008
   You FT, 2023, BIOMED PHARMACOTHER, V162, DOI 10.1016/j.biopha.2023.114555
   Zargar Abdul, 2005, J Indian Med Assoc, V103, P444
   Zhang Y, 2023, J NEUROSURG, V138, P1254, DOI 10.3171/2022.9.JNS221251
   Zhang ZX, 2024, FRONT GENET, V15, DOI 10.3389/fgene.2024.1397390
   Zhao LQ, 2016, ONCOTARGET, V7, P4483, DOI 10.18632/oncotarget.6605
   Zhou WH, 2019, CANCERS, V11, DOI 10.3390/cancers11091231
   Zimmet P, 2001, NATURE, V414, P782, DOI 10.1038/414782a
NR 113
TC 0
Z9 0
U1 4
U2 4
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD MAY
PY 2025
VL 215
AR 107719
DI 10.1016/j.phrs.2025.107719
EA APR 2025
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 1BC5Y
UT WOS:001460811100001
PM 40174814
DA 2025-06-11
ER

PT J
AU Wu, Y
   Zhou, H
   Wu, K
   Lee, S
   Li, RJ
   Liu, X
AF Wu, Yong
   Zhou, Hillary
   Wu, Ke
   Lee, Sangkyu
   Li, Ruijin
   Liu, Xuan
TI PTEN Phosphorylation and Nuclear Export Mediate Free Fatty Acid-Induced
   Oxidative Stress
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE; NITRIC-OXIDE SYNTHASE; GLUTATHIONE-PEROXIDASE
   DEFICIENCY; TUMOR-SUPPRESSOR; P53 ACETYLATION; REACTIVE OXYGEN;
   ATHEROSCLEROSIS SUSCEPTIBILITY; ENDOTHELIAL DYSFUNCTION;
   SUPEROXIDE-DISMUTASE; METABOLIC SYNDROME
AB Aim: Oxidative stress induced by free fatty acids (FFA) contributes to metabolic syndrome-associated development of cardiovascular diseases, yet molecular mechanisms remain poorly understood. This study aimed at establishing whether phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and its subcellular location play a role in FFA-induced endothelial oxidative stress. Results: Exposing human endothelial cells (ECs) with FFA activated mammalian target of rapamycin (mTOR)/S6K pathway, and upon activation, S6K directly phosphorylated PTEN at S380. Phosphorylation of PTEN increased its interaction with its deubiquitinase USP7 in the nucleus, leading to PTEN deubiquitination and nuclear export. The reduction of PTEN in the nucleus, in turn, decreased p53 acetylation and transcription, reduced the expression of the p53 target gene glutathione peroxidase-1 (GPX1), resulting in reactive oxygen species (ROS) accumulation and endothelial damage. Finally, C57BL/6J mice fed with high-fat atherogenic diet (HFAD) showed PTEN nuclear export, decreased p53 and GPX1 protein expressions, elevated levels of ROS, and significant lesions in aortas. Importantly, inhibition of mTOR or S6K effectively blocked these effects, suggesting that mTOR/S6K pathway mediates HFAD-induced oxidative stress and vascular damage via PTEN/p53/GPX1 inhibition in vivo. Innovation: Our study demonstrated for the first time that S6K directly phosphorylated PTEN at S380 under high FFA conditions, and this phosphorylation mediated FFA-induced endothelial oxidative stress. Furthermore, we showed that S380 phosphorylation affected PTEN monoubiquitination and nuclear localization, providing the first example of coordinated regulation of PTEN nuclear localization via phosphorylation and ubiquitination. Conclusion: Our studies provide a novel mechanism by which hyperlipidemia causes vascular oxidative damage through the phosphorylation of PTEN, blocking of PTEN nuclear function, and inhibition of p53/GPX1 activity. Antioxid. Redox Signal. 20, 1382-1395.
C1 [Wu, Yong; Zhou, Hillary; Lee, Sangkyu; Li, Ruijin; Liu, Xuan] Univ Calif Riverside, Dept Biochem, Riverside, CA 92521 USA.
   [Wu, Ke] Wuhan Univ, Med Res Ctr, ABSL Lab 3, Ctr Expt Anim, Hubei, Peoples R China.
C3 University of California System; University of California Riverside;
   Wuhan University
RP Liu, X (corresponding author), Univ Calif Riverside, Dept Biochem, Riverside, CA 92521 USA.
EM xuan.liu@ucr.edu
RI wu, ke/AHE-3113-2022
OI Wu, Yong/0000-0002-1698-0897; wu, ke/0000-0002-7195-9601
FU NIH [CA075180]; American Heart Association [POST3530033]
FX We are grateful to Dr. John Shyy for valuable suggestions and helpful
   discussion. We thank all members of our laboratory for discussions. This
   work was supported by NIH Grant CA075180 to X.L. and by American Heart
   Association Award POST3530033 to Y.W.
CR Bashan N, 2009, PHYSIOL REV, V89, P27, DOI 10.1152/physrev.00014.2008
   BERRY MJ, 1991, NATURE, V353, P273, DOI 10.1038/353273a0
   Birle D, 2002, J IMMUNOL, V169, P286, DOI 10.4049/jimmunol.169.1.286
   Bode AM, 2004, NAT REV CANCER, V4, P793, DOI 10.1038/nrc1455
   Cai X, 2008, P NATL ACAD SCI USA, V105, P16958, DOI 10.1073/pnas.0804608105
   Carlström M, 2010, P NATL ACAD SCI USA, V107, P17716, DOI 10.1073/pnas.1008872107
   Chalupsky K, 2005, P NATL ACAD SCI USA, V102, P9056, DOI 10.1073/pnas.0409594102
   Chang CJ, 2008, MOL CELL BIOL, V28, P3281, DOI 10.1128/MCB.00310-08
   Déléris P, 2003, J BIOL CHEM, V278, P38884, DOI 10.1074/jbc.M300816200
   Flohe L, 1988, Basic Life Sci, V49, P663
   Forgione MA, 2002, CIRCULATION, V106, P1154, DOI 10.1161/01.CIR.0000026820.87824.6A
   Forgione MA, 2002, AM J PHYSIOL-HEART C, V282, pH1255, DOI 10.1152/ajpheart.00598.2001
   Formoso G, 2006, MOL ENDOCRINOL, V20, P1153, DOI 10.1210/me.2005-0266
   Freeman DJ, 2003, CANCER CELL, V3, P117, DOI 10.1016/S1535-6108(03)00021-7
   GRANKVIST K, 1981, BIOCHEM J, V199, P393, DOI 10.1042/bj1990393
   Haffner S, 2003, CIRCULATION, V108, P1541, DOI 10.1161/01.CIR.0000088845.17586.EC
   Ignarro LJ, 1999, J CARDIOVASC PHARM, V34, P879, DOI 10.1097/00005344-199912000-00016
   Inoguchi T, 2000, DIABETES, V49, P1939, DOI 10.2337/diabetes.49.11.1939
   Ito A, 2001, EMBO J, V20, P1331, DOI 10.1093/emboj/20.6.1331
   Jouven X, 2001, CIRCULATION, V104, P756, DOI 10.1161/hc3201.094151
   Kang KH, 2009, TRENDS MOL MED, V15, P191, DOI 10.1016/j.molmed.2009.03.005
   Kunjathoor VV, 1996, J CLIN INVEST, V97, P1767, DOI 10.1172/JCI118604
   Laws A, 1997, ARTERIOSCL THROM VAS, V17, P64, DOI 10.1161/01.ATV.17.1.64
   Lei XG, 2007, ANNU REV NUTR, V27, P41, DOI 10.1146/annurev.nutr.27.061406.093716
   Li AG, 2007, MOL CELL, V28, P408, DOI 10.1016/j.molcel.2007.09.006
   Li AG, 2006, MOL CELL, V23, P575, DOI 10.1016/j.molcel.2006.06.028
   Li J, 1997, SCIENCE, V275, P1943, DOI 10.1126/science.275.5308.1943
   Li SJ, 2000, CANCER RES, V60, P3927
   Li WG, 2001, J BIOL CHEM, V276, P29251, DOI 10.1074/jbc.M102124200
   Lian ZL, 2005, ONCOGENE, V24, P7394, DOI 10.1038/sj.onc.1209089
   LIAO F, 1993, J CLIN INVEST, V91, P2572, DOI 10.1172/JCI116495
   Lin SJ, 2004, J MOL CELL CARDIOL, V36, P129, DOI 10.1016/j.yjmcc.2003.10.011
   Liu B, 2008, FREE RADICAL BIO MED, V44, P1529, DOI 10.1016/j.freeradbiomed.2008.01.011
   Liu JL, 2007, CANCER RES, V67, P11054, DOI 10.1158/0008-5472.CAN-07-1263
   Maddika S, 2011, NAT CELL BIOL, V13, P728, DOI 10.1038/ncb2240
   Mercer J, 2006, CELL CYCLE, V5, P1907, DOI 10.4161/cc.5.17.3166
   Ming XF, 2012, FRONT PHYSIOL, V3, DOI 10.3389/fphys.2012.00005
   Mueller MA, 2008, ATHEROSCLEROSIS, V198, P39, DOI 10.1016/j.atherosclerosis.2007.09.019
   PAIGEN B, 1987, P NATL ACAD SCI USA, V84, P3763, DOI 10.1073/pnas.84.11.3763
   PAIGEN B, 1990, ARTERIOSCLEROSIS, V10, P316, DOI 10.1161/01.ATV.10.2.316
   PAIGEN B, 1987, ATHEROSCLEROSIS, V68, P231, DOI 10.1016/0021-9150(87)90202-4
   Paravicini TM, 2006, CARDIOVASC RES, V71, P247, DOI 10.1016/j.cardiores.2006.05.001
   Pearson M, 2000, NATURE, V406, P207, DOI 10.1038/35018127
   Planchon SM, 2008, J CELL SCI, V121, P249, DOI 10.1242/jcs.022459
   Sablina AA, 2005, NAT MED, V11, P1306, DOI 10.1038/nm1320
   Schnabel R, 2005, J AM COLL CARDIOL, V45, P1631, DOI 10.1016/j.jacc.2005.02.053
   Schreyer SA, 1998, ATHEROSCLEROSIS, V136, P17, DOI 10.1016/S0021-9150(97)00165-2
   Shabek N, 2010, CELL CYCLE, V9, P523, DOI 10.4161/cc.9.3.11152
   Solomon JM, 2006, MOL CELL BIOL, V26, P28, DOI 10.1128/MCB.26.1.28-38.2006
   Song MS, 2008, NATURE, V455, P813, DOI 10.1038/nature07290
   Song MS, 2012, NAT REV MOL CELL BIO, V13, P283, DOI 10.1038/nrm3330
   Steinberg HO, 1996, J CLIN INVEST, V97, P2601, DOI 10.1172/JCI118709
   Tan MJ, 1999, J BIOL CHEM, V274, P12061, DOI 10.1074/jbc.274.17.12061
   Trotman LC, 2007, CELL, V128, P141, DOI 10.1016/j.cell.2006.11.040
   Wang LM, 2008, AM J PHYSIOL-HEART C, V295, pH237, DOI 10.1152/ajpheart.01366.2007
   Wang XL, 2006, DIABETES, V55, P2301, DOI 10.2337/db05-1574
   Wang XJ, 2007, CELL, V128, P129, DOI 10.1016/j.cell.2006.11.039
   Wu Y, 2007, J BIOL CHEM, V282, P9777, DOI 10.1074/jbc.M608310200
   Zhang YF, 2005, CIRC RES, V96, P831, DOI 10.1161/01.RES.0000164401.21929.CF
NR 59
TC 38
Z9 42
U1 0
U2 23
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD MAR 20
PY 2014
VL 20
IS 9
BP 1382
EP 1395
DI 10.1089/ars.2013.5498
PG 14
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA AB8BE
UT WOS:000332014300002
PM 24063548
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Patel, PJ
   Weidenfeller, C
   Jones, AP
   Nilsson, J
   Hsu, J
AF Patel, Preeya J.
   Weidenfeller, Christian
   Jones, Andrew P.
   Nilsson, Jens
   Hsu, Jay
TI Long-Term Assessment of Lurasidone in Schizophrenia: Post Hoc Analysis
   of a 12-Month, Double Blind, Active-Controlled Trial and 6-Month
   Open-Label Extension Study
SO NEUROLOGY AND THERAPY
LA English
DT Article
DE Atypical antipsychotic; Cardiometabolic; Lurasidone; Metabolic syndrome;
   Prolactin; Risperidone; Schizophrenia; Switch
ID SCHIZOAFFECTIVE DISORDER; CONFIDENCE-INTERVALS; METABOLIC SYNDROME;
   SCALE; ANTIPSYCHOTICS; METAANALYSIS; PREVALENCE; MORTALITY; DISEASE;
   RISK
AB Introduction A post hoc analysis of a double-blind (DB) active control trial and an open-label extension (OLE) study was conducted to evaluate the long-term effects of lurasidone in patients with schizophrenia. Methods In the DB trial, patients were randomised to receive lurasidone or risperidone for 12 months. In OLE, all patients received lurasidone for an additional 6 months. Treatment-emergent adverse events (TEAEs) were evaluated. Efficacy assessments included relapse rate (DB trial only), and Positive and Negative Syndrome Scale, Clinical Global Impression-Severity scale, and Montgomery-angstrom sberg Depression Rating Scale. Results In the DB trial, patients with schizophrenia were randomised to lurasidone (n = 399) and risperidone (n = 190), of whom 129 and 84 continued into OLE, respectively. During the DB trial, incidence of TEAEs was similar for lurasidone (84.1%) and risperidone (84.2%). Lurasidone was associated with minimal changes in metabolic variables and prolactin levels, whereas risperidone was associated with clinically significant increases in prolactin and fasting glucose levels. The proportion of patients with metabolic syndrome was significantly lower in patients treated with lurasidone versus risperidone at the end of the DB trial (25.5% vs 40.4%; p = 0.0177). During OLE, patients switching from risperidone to lurasidone experienced a reduction in weight and prolactin levels; those continuing treatment with lurasidone experienced minimal changes in metabolic variables and prolactin. At the end of OLE, the proportion of patients with metabolic syndrome was no longer significantly different between groups (23.5% vs 31.5%; p = not significant). Efficacy outcomes were generally similar between groups during the DB trial, and were maintained during OLE. Conclusion Lurasidone was generally well tolerated and effective in clinically stable schizophrenia patients over the long term. Lurasidone was also generally well tolerated and maintained effectiveness over 6 months in patients switching from risperidone. Patients switching from risperidone experienced improvements in metabolic parameters and prolactin levels. These findings confirm lurasidone's long-term effectiveness and favourable metabolic profile in patients with schizophrenia.
C1 [Patel, Preeya J.; Weidenfeller, Christian; Jones, Andrew P.; Nilsson, Jens] Sunov Pharmaceut Europe Ltd, London, England.
   [Hsu, Jay] Sunov Pharmaceut Inc, Ft Lee, NJ USA.
C3 Dainippon Sumitomo Pharmaceutical Company; Sunovion Pharmaceuticals
   Inc.; Dainippon Sumitomo Pharmaceutical Company; Sunovion
   Pharmaceuticals Inc.
RP Patel, PJ (corresponding author), Sunov Pharmaceut Europe Ltd, London, England.
EM Preeya.Patel@sunovion.com
RI Rajagopalan, Krithika/AAZ-7034-2021; Jones, Andy/ABB-9742-2021
FU Sunovion Pharmaceuticals Europe Ltd.
FX The study was funded by Sunovion Pharmaceuticals Europe Ltd. The
   journal's Rapid Service Fees were also funded by Sunovion
   Pharmaceuticals Europe Ltd.
CR Altman DG, 1998, BRIT MED J, V317, P1309, DOI 10.1136/bmj.317.7168.1309
   Aziende Chimiche Riunite Angelini Francesco-A.C.R.A.F. S.p.A, 2020, SPA LAT SUMM PROD CH
   BARNES TRE, 1989, BRIT J PSYCHIAT, V154, P672, DOI 10.1192/bjp.154.5.672
   Bender R, 2001, CONTROL CLIN TRIALS, V22, P102, DOI 10.1016/S0197-2456(00)00134-3
   Citrome L, 2014, CNS SPECTRUMS, V19, P330, DOI 10.1017/S109285291300093X
   Citrome L, 2012, INT CLIN PSYCHOPHARM, V27, P165, DOI 10.1097/YIC.0b013e32835281ef
   Cooper SJ, 2016, J PSYCHOPHARMACOL, V30, P717, DOI 10.1177/0269881116645254
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   Hert M, 2012, NAT REV ENDOCRINOL, V8, P114, DOI 10.1038/nrendo.2011.156
   Filipcic IS, 2018, PSYCHIAT DANUB, V30, pS152
   Firth J, 2019, LANCET PSYCHIAT, V6, P675, DOI 10.1016/S2215-0366(19)30132-4
   Grajales D, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8111336
   Greenberg WM, 2017, CLIN PHARMACOKINET, V56, P493, DOI 10.1007/s40262-016-0465-5
   GROSSMAN LS, 1991, AM J PSYCHIAT, V148, P1359
   Guy W., 1976, U.S. Department of Health, Education, P76
   Harrow M, 2000, BRIT J PSYCHIAT, V177, P421, DOI 10.1192/bjp.177.5.421
   Huhn M, 2019, LANCET, V394, P939, DOI [10.1016/S0140-6736(19)31135-3, 10.1176/appi.focus.18306]
   Janssen-Cilag Ltd, 2008, RISP SUMM PROD CHAR
   KAY SR, 1987, SCHIZOPHRENIA BULL, V13, P261, DOI 10.1093/schbul/13.2.261
   Kim DH, 2009, NEUROTHERAPEUTICS, V6, P78, DOI 10.1016/j.nurt.2008.10.020
   Laursen TM, 2014, ANNU REV CLIN PSYCHO, V10, P425, DOI 10.1146/annurev-clinpsy-032813-153657
   Leucht S, 2020, CINP SCHIZOPHRENIA G
   Leucht S, 2017, AM J PSYCHIAT, V174, P927, DOI 10.1176/appi.ajp.2017.16121358
   Mattingly GW, 2020, BMC PSYCHIATRY, V20, DOI 10.1186/s12888-020-02523-1
   McEvoy JP, 2013, J CLIN PSYCHIAT, V74, P170, DOI 10.4088/JCP.12m07992
   Meyer JM, 2015, INT CLIN PSYCHOPHARM, V30, P342, DOI 10.1097/YIC.0000000000000091
   MONTGOMERY SA, 1979, BRIT J PSYCHIAT, V134, P382, DOI 10.1192/bjp.134.4.382
   Muñoz-Negro JE, 2019, ACTAS ESP PSIQUIATRI, V47, P190
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Roth GA, 2018, LANCET, V392, P1736, DOI 10.1016/S0140-6736(18)32203-7
   Simpson G M, 1970, Acta Psychiatr Scand Suppl, V212, P11
   Stahl SM, 2013, J CLIN PSYCHIAT, V74, P507, DOI 10.4088/JCP.12m08084
   Sunovion Pharmaceuticals Inc, 2019, LAT PRESCR INF
   Taylor D.M., 2018, MAUDSLEY PRESCRIBING
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vancampfort D, 2013, WORLD PSYCHIATRY, V12, P240, DOI 10.1002/wps.20069
   Wy TJP, 2020, SCHIZ DIS
NR 37
TC 5
Z9 6
U1 1
U2 4
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 2193-8253
EI 2193-6536
J9 NEUROL THER
JI Neurol. Ther.
PD JUN
PY 2021
VL 10
IS 1
BP 121
EP 147
DI 10.1007/s40120-020-00221-4
EA OCT 2020
PG 27
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA SF9AL
UT WOS:000582312300001
PM 33098548
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vona, R
   Gambardella, L
   Cittadini, C
   Straface, E
   Pietraforte, D
AF Vona, Rosa
   Gambardella, Lucrezia
   Cittadini, Camilla
   Straface, Elisabetta
   Pietraforte, Donatella
TI Biomarkers of Oxidative Stress in Metabolic Syndrome and Associated
   Diseases
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID INSULIN-RESISTANCE; NADPH OXIDASE; FRUCTOSE; OBESITY
AB Metabolic syndrome (MS) represents worldwide public health issue characterized by a set of cardiovascular risk factors including obesity, diabetes, dyslipidemia, hypertension, and impaired glucose tolerance. The link between the MS and the associated diseases is represented by oxidative stress (OS) and by the intracellular redox imbalance, both caused by the persistence of chronic inflammatory conditions that characterize MS. The increase in oxidizing species formation in MS has been accepted as a major underlying mechanism for mitochondrial dysfunction, accumulation of protein and lipid oxidation products, and impairment of the antioxidant systems. These oxidative modifications are recognized as relevant OS biomarkers potentially able to (i) clarify the role of reactive oxygen and nitrogen species in the etiology of the MS, (ii) contribute to the diagnosis/evaluation of the disease's severity, and (iii) evaluate the utility of possible therapeutic strategies based on natural antioxidants. The antioxidant therapies indeed could be able to (i) counteract systemic as well as mitochondrial-derived OS, (ii) enhance the endogenous antioxidant defenses, (iii) alleviate MS symptoms, and (iv) prevent the complications linked to MS-derived cardiovascular diseases. The focus of this review is to summarize the current knowledge about the role of OS in the development of metabolic alterations characterizing MS, with particular regard to the occurrence of OS-correlated biomarkers, as well as to the use of therapeutic strategies based on natural antioxidants.
C1 [Vona, Rosa; Gambardella, Lucrezia; Cittadini, Camilla; Straface, Elisabetta] Ist Super Sanita, Ctr Gender Specif Med, Biomarkers Unit, Rome, Italy.
   [Pietraforte, Donatella] Ist Super Sanita, Core Facil, Rome, Italy.
C3 Istituto Superiore di Sanita (ISS); Istituto Superiore di Sanita (ISS)
RP Straface, E (corresponding author), Ist Super Sanita, Ctr Gender Specif Med, Biomarkers Unit, Rome, Italy.
EM rosa.vona@iss.it; lucrezia.gambardella@iss.it;
   camilla.cittadini@virgilio.it; elisabetta.straface@iss.it;
   donatella.pietraforte@iss.it
RI Pietraforte, Donatella/G-1816-2011; Vona, Rosa/AAL-4747-2021; Cittadini,
   Camilla/HSC-1541-2023
OI Gambardella, Lucrezia/0000-0003-3899-5958; Cittadini,
   Camilla/0000-0002-1403-6608; Vona, Rosa/0000-0003-4501-8661
FU Ministry of Health [RF-2013-02358715]
FX This study was supported in part by a grant from the Ministry of Health
   (RF-2013-02358715) awarded to E.S. The authors thank Ms. Carlotta
   Catalano for the linguistic revision of the manuscript.
CR Abete I, 2010, NUTR REV, V68, P214, DOI 10.1111/j.1753-4887.2010.00280.x
   ADLAM V, 2002, THE FASEB JOURNAL, V19, P1088, DOI DOI 10.1096/FJ.05-3718COM
   Akoumianakis I, 2019, ANTIOXID REDOX SIGN, V30, P333, DOI 10.1089/ars.2017.7421
   ALFANO M, 2002, UROLOGY, V13, P77, DOI DOI 10.1038/NRUROL.2015.292
   Aller EEJG, 2011, NUTRIENTS, V3, P341, DOI 10.3390/nu3030341
   Amirkhizi F, 2014, OBES RES CLIN PRACT, V8, pE26, DOI 10.1016/j.orcp.2012.07.004
   Anderson EJ, 2009, J CLIN INVEST, V119, P573, DOI 10.1172/JCI37048
   Aouacheri O, 2015, CAN J DIABETES, V39, P44, DOI 10.1016/j.jcjd.2014.03.002
   Armutcu F, 2008, CLIN CHEM LAB MED, V46, P785, DOI 10.1515/CCLM.2008.166
   Augé N, 2004, CIRCULATION, V110, P571, DOI 10.1161/01.CIR.0000136995.83451.1D
   Bäckhed F, 2005, SCIENCE, V307, P1915, DOI 10.1126/science.1104816
   Bagul PK, 2012, PHARMACOL RES, V66, P260, DOI 10.1016/j.phrs.2012.05.003
   Bahadoran Z, 2013, J DIABETES METAB DIS, V12, DOI 10.1186/2251-6581-12-43
   Bahadoran Z, 2013, J MED FOOD, V16, P375, DOI 10.1089/jmf.2012.2559
   Bartberger MD, 2002, P NATL ACAD SCI USA, V99, P10958, DOI 10.1073/pnas.162095599
   Berliner S, 2005, AM HEART J, V149, P260, DOI 10.1016/j.ahj.2004.05.058
   Bhatraju NK, 2017, ANN AM THORAC SOC, V14, pS368, DOI 10.1513/AnnalsATS.201701-042AW
   BONOMINI F, 2002, AGING AND DISEASE, V6, P109, DOI DOI 10.1038/NATURE04634
   Bostan C, 2015, ANGIOLOGY, V66, P122, DOI 10.1177/0003319714522107
   Brasier AR, 2002, ARTERIOSCL THROM VAS, V22, P1257, DOI 10.1161/01.ATV.0000021412.56621.A2
   Bray GA, 2002, J NUTR, V132, P2488, DOI 10.1093/jn/132.9.2488
   Bray GA, 2004, AM J CLIN NUTR, V79, P537
   Broedbaek K, 2011, FREE RADICAL BIO MED, V51, P1473, DOI 10.1016/j.freeradbiomed.2011.07.007
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   BUETTNER GR, 1993, FREE RADICAL BIO MED, V14, P49, DOI 10.1016/0891-5849(93)90508-R
   Buettner R, 2007, OBESITY, V15, P798, DOI 10.1038/oby.2007.608
   Chattopadhyay M, 2015, MOL CELL BIOCHEM, V399, P95, DOI 10.1007/s11010-014-2236-7
   Cheng XH, 2011, ANTIOXID REDOX SIGN, V14, P469, DOI 10.1089/ars.2010.3283
   Cheng ZY, 2014, CELL CYCLE, V13, P890, DOI 10.4161/cc.28189
   Cheng ZY, 2010, TRENDS ENDOCRIN MET, V21, P589, DOI 10.1016/j.tem.2010.06.005
   CHIURCHIU V, 2002, ANTIOXIDANTS AND RED, V15, P2605, DOI DOI 10.1089/ARS.2010.3547
   Chong MF, 2013, EUR J NUTR, V52, P361, DOI 10.1007/s00394-012-0343-3
   Chowdhury SKR, 2010, AM J PHYSIOL-ENDOC M, V298, pE89, DOI 10.1152/ajpendo.00433.2009
   Cohen Richard A, 2005, Am J Ther, V12, P499, DOI 10.1097/01.mjt.0000178776.77267.19
   Csiszar A, 2008, AM J PHYSIOL-HEART C, V295, pH475, DOI 10.1152/ajpheart.00644.2008
   Dalle-Donne I, 2006, J CELL MOL MED, V10, P389, DOI 10.1111/j.1582-4934.2006.tb00407.x
   DAS S, 2000, TARGETS, V6, P168, DOI DOI 10.2174/187152807781696464
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   Dekker MJ, 2010, AM J PHYSIOL-ENDOC M, V299, pE685, DOI 10.1152/ajpendo.00283.2010
   Di Luccia B, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0134893
   Dianzani Mario Umberto, 2003, Molecular Aspects of Medicine, V24, P263
   Dikalov S, 2011, FREE RADICAL BIO MED, V51, P1289, DOI 10.1016/j.freeradbiomed.2011.06.033
   DING H, 2002, JOURNAL OF CELLULAR, V212, P682, DOI DOI 10.1002/JCP.21063
   Doughan AK, 2008, CIRC RES, V102, P488, DOI 10.1161/CIRCRESAHA.107.162800
   Eckburg PB, 2005, SCIENCE, V308, P1635, DOI 10.1126/science.1110591
   Egert S, 2009, BRIT J NUTR, V102, P1065, DOI 10.1017/S0007114509359127
   Eiserich JP, 1996, J BIOL CHEM, V271, P19199, DOI 10.1074/jbc.271.32.19199
   Elliott SS, 2002, AM J CLIN NUTR, V76, P911, DOI 10.1093/ajcn/76.5.911
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   Fava F, 2019, P NUTR SOC, V78, P177, DOI 10.1017/S0029665118002719
   Fava F, 2013, INT J OBESITY, V37, P216, DOI 10.1038/ijo.2012.33
   Fernandez-Marcos PJ, 2016, ONCOTARGET, V7, P50814, DOI 10.18632/oncotarget.10744
   Ferrarese R, 2018, EUR REV MED PHARMACO, V22, P7588, DOI 10.26355/eurrev_201811_16301
   FOSTER M, 2002, TRENDS IN MOLECULAR, V9, P160, DOI DOI 10.1016/S1471-4914(03)00028-5
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gibson GR, 2017, NAT REV GASTRO HEPAT, V14, P491, DOI 10.1038/nrgastro.2017.75
   Goligorsky MS, 2017, AM J PHYSIOL-RENAL, V312, pF266, DOI 10.1152/ajprenal.00473.2016
   Gomes LC, 2011, NAT CELL BIOL, V13, P589, DOI 10.1038/ncb2220
   Gregório BM, 2016, CURR PHARM DESIGN, V22, P859, DOI 10.2174/1381612822666151209152352
   Guasch-Ferré M, 2017, J AM HEART ASSOC, V6, DOI [10.1161/jaha.117.006524, 10.1161/JAHA.117.006524]
   Gyawali P, 2015, REDOX REP, V20, P139, DOI 10.1179/1351000214Y.0000000120
   Haffner S, 2003, CIRCULATION, V108, P1541, DOI 10.1161/01.CIR.0000088845.17586.EC
   Hammond RA, 2010, DIABETES METAB SYNDR, V3, P285, DOI [10.2147/DMSOTT.S7384, 10.2147/DMSO.S7384]
   Hermans N, 2017, TRIALS, V18, DOI 10.1186/s13063-017-2058-5
   Hildebrandt MA, 2009, GASTROENTEROLOGY, V137, P1716, DOI 10.1053/j.gastro.2009.08.042
   Hill C, 2014, NAT REV GASTRO HEPAT, V11, P506, DOI 10.1038/nrgastro.2014.66
   Holvoet P, 2004, DIABETES, V53, P1068, DOI 10.2337/diabetes.53.4.1068
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Huang HP, 2018, BMC INFECT DIS, V18, DOI 10.1186/s12879-017-2932-5
   Huynh K, 2012, DIABETOLOGIA, V55, P1544, DOI 10.1007/s00125-012-2495-3
   Iglesia I, 2017, EUR J NUTR, V56, P1767, DOI 10.1007/s00394-016-1221-1
   Ilkun O, 2015, J MOL CELL CARDIOL, V85, P104, DOI 10.1016/j.yjmcc.2015.05.012
   Inoguchi T, 2000, DIABETES, V49, P1939, DOI 10.2337/diabetes.49.11.1939
   Jankovic A, 2014, METABOLISM, V63, P661, DOI 10.1016/j.metabol.2014.01.009
   Janssen-Heininger YMW, 2008, FREE RADICAL BIO MED, V45, P1, DOI 10.1016/j.freeradbiomed.2008.03.011
   Jesmin S, 2006, EXP BIOL MED, V231, P925
   Jialal I, 2012, J CLIN ENDOCR METAB, V97, pE1844, DOI 10.1210/jc.2012-2498
   Joseph AM, 2012, AGING CELL, V11, P801, DOI 10.1111/j.1474-9726.2012.00844.x
   Kay AM, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/6809703
   Kayama Y, 2015, INT J MOL SCI, V16, P25234, DOI 10.3390/ijms161025234
   Kelishadi R, 2014, NUTRITION, V30, P503, DOI 10.1016/j.nut.2013.08.014
   Kelley DE, 2002, DIABETES, V51, P2944, DOI 10.2337/diabetes.51.10.2944
   Klinder A, 2016, FOOD FUNCT, V7, P1788, DOI [10.1039/C5FO01096A, 10.1039/c5fo01096a]
   Kocharian A, 2009, CARDIOL YOUNG, V19, P501, DOI 10.1017/S1047951109990795
   Korytár P, 2002, GEN PHYSIOL BIOPHYS, V21, P337
   Lahera V, 2017, CURR HYPERTENS REP, V19, DOI 10.1007/s11906-017-0710-9
   Lassègue B, 2010, ARTERIOSCL THROM VAS, V30, P653, DOI 10.1161/ATVBAHA.108.181610
   LAVIE C, 2002, HCR, V31, P211, DOI DOI 10.1097/HCR.0B013E318211E3D8
   Lee RMKW, 2017, HYPERTENS RES, V40, P311, DOI 10.1038/hr.2016.145
   Ley RE, 2006, CELL, V124, P837, DOI 10.1016/j.cell.2006.02.017
   Li HG, 2013, TRENDS PHARMACOL SCI, V34, P313, DOI 10.1016/j.tips.2013.03.007
   Li JM, 2003, J AM SOC NEPHROL, V14, pS221, DOI 10.1097/01.ASN.0000077406.67663.E7
   Li M, 2008, P NATL ACAD SCI USA, V105, P2117, DOI 10.1073/pnas.0712038105
   Liesa M, 2013, CELL METAB, V17, P491, DOI 10.1016/j.cmet.2013.03.002
   Lönn ME, 2012, FREE RADICAL BIO MED, V53, P863, DOI 10.1016/j.freeradbiomed.2012.05.027
   MACREADY A, 2002, THE AMERICAN JOURNAL, V99, P479, DOI DOI 10.3945/AJCN.113.074237
   Marrocco Ilaria, 2017, Oxid Med Cell Longev, V2017, P6501046, DOI 10.1155/2017/6501046
   Martin SD, 2014, BBA-GEN SUBJECTS, V1840, P1303, DOI 10.1016/j.bbagen.2013.09.019
   Marzetti E, 2009, BIOFACTORS, V35, P28, DOI 10.1002/biof.5
   Matsuda M, 2013, OBES RES CLIN PRACT, V7, pE330, DOI 10.1016/j.orcp.2013.05.004
   Matsuzawa-Nagata N, 2008, METABOLISM, V57, P1071, DOI 10.1016/j.metabol.2008.03.010
   Mazmanian SK, 2005, CELL, V122, P107, DOI 10.1016/j.cell.2005.05.007
   Mercer JR, 2012, FREE RADICAL BIO MED, V52, P841, DOI 10.1016/j.freeradbiomed.2011.11.026
   Mirmiran P, 2018, CASP J INTERN MED, V9, P376, DOI 10.22088/cjim.9.4.376
   Mootha VK, 2003, CELL, V115, P629, DOI 10.1016/S0092-8674(03)00926-7
   Morgen CS, 2014, NAT REV ENDOCRINOL, V10, P513, DOI 10.1038/nrendo.2014.124
   Münzel T, 2010, EUR HEART J, V31, P2741, DOI 10.1093/eurheartj/ehq396
   Nallu A, 2017, TRANSL RES, V179, P24, DOI 10.1016/j.trsl.2016.04.007
   Niemann B, 2011, J AM COLL CARDIOL, V57, P577, DOI 10.1016/j.jacc.2010.09.040
   Nussbaum C, 2013, ANTIOXID REDOX SIGN, V18, P692, DOI 10.1089/ars.2012.4783
   O'Keefe JH, 2007, AM J CARDIOL, V100, P899, DOI 10.1016/j.amjcard.2007.03.107
   Otani H, 2011, ANTIOXID REDOX SIGN, V15, P1911, DOI 10.1089/ars.2010.3739
   Palmeira C. M., 2012, METHOD MOL BIOL, V810, P381
   Palmieri VO, 2006, J NUTR, V136, P3022, DOI 10.1093/jn/136.12.3022
   Panahi Y, 2015, CLIN NUTR, V34, P1101, DOI 10.1016/j.clnu.2014.12.019
   PANCHAL S, 2002, THE JOURNAL OF NUTRI, V142, P1026, DOI DOI 10.3945/JN.111.157263
   Parks BW, 2013, CELL METAB, V17, P141, DOI 10.1016/j.cmet.2012.12.007
   Pechánová O, 2015, BRIT J PHARMACOL, V172, P1415, DOI 10.1111/bph.12960
   Perez S, 2009, VEH TECHNOL CONFE, P2789
   Ploumi C, 2017, FEBS J, V284, P183, DOI 10.1111/febs.13820
   Privratsky JR, 2003, HYPERTENSION, V42, P206, DOI 10.1161/01.HYP.0000082814.62655.85
   Puddu P, 2005, CARDIOLOGY, V103, P137, DOI 10.1159/000083440
   Pung YF, 2012, ARTERIOSCL THROM VAS, V32, P325, DOI 10.1161/ATVBAHA.111.241802
   Qin FZ, 2012, CIRCULATION, V125, P1757, DOI 10.1161/CIRCULATIONAHA.111.067801
   Radi R, 2018, P NATL ACAD SCI USA, V115, P5839, DOI 10.1073/pnas.1804932115
   Rafighi Zahra, 2013, Glob J Health Sci, V5, P183, DOI 10.5539/gjhs.v5n3p183
   RAMBOLD A, 2002, PROCEEDINGS OF THE N, V108, P10190, DOI DOI 10.1073/PNAS.1107402108
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   Rask-Madsen C, 2013, CELL METAB, V17, P20, DOI 10.1016/j.cmet.2012.11.012
   Ray PD, 2012, CELL SIGNAL, V24, P981, DOI 10.1016/j.cellsig.2012.01.008
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Robich MP, 2011, EUR J PHARMACOL, V664, P45, DOI 10.1016/j.ejphar.2011.04.059
   Rossier MF, 2006, CELL CALCIUM, V40, P155, DOI 10.1016/j.ceca.2006.04.020
   Sablina AA, 2005, NAT MED, V11, P1306, DOI 10.1038/nm1320
   Sangle GV, 2010, ENDOCRINOLOGY, V151, P4455, DOI 10.1210/en.2010-0323
   Schober A, 2008, ARTERIOSCL THROM VAS, V28, P1950, DOI 10.1161/ATVBAHA.107.161224
   Sekirov I, 2010, PHYSIOL REV, V90, P859, DOI 10.1152/physrev.00045.2009
   SHEN G, 2002, TARGETS, V12, P106, DOI DOI 10.2174/1871529X11202020106
   Shen XC, 2012, BMC COMPLEM ALTERN M, V12, DOI 10.1186/1472-6882-12-174
   Signorini C, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/343824
   Smith RAJ, 2011, DISCOV MED, V11, P106
   Spahis S, 2017, ANTIOXID REDOX SIGN, V26, P445, DOI 10.1089/ars.2016.6756
   Stadtman ER, 2003, AMINO ACIDS, V25, P207, DOI 10.1007/s00726-003-0011-2
   Stanhope KL, 2009, J CLIN INVEST, V119, P1322, DOI 10.1172/JCI37385
   Stefano GB, 2016, EUR J NUTR, V55, P2339, DOI 10.1007/s00394-016-1212-2
   Straface E, 2002, BIOCHEM BIOPH RES CO, V290, P1393, DOI 10.1006/bbrc.2002.6340
   Straface Elisabetta, 2011, Int J Cell Biol, V2011, P204157, DOI 10.1155/2011/204157
   Subramanian Sharath, 2010, Recent Pat Cardiovasc Drug Discov, V5, P54
   Szabo C, 2009, BRIT J PHARMACOL, V156, P713, DOI 10.1111/j.1476-5381.2008.00086.x
   Tang WHW, 2017, CIRC RES, V120, P1183, DOI 10.1161/CIRCRESAHA.117.309715
   Tappy L, 2010, PHYSIOL REV, V90, P23, DOI 10.1152/physrev.00019.2009
   Teshima Y, 2014, CIRC J, V78, P300, DOI 10.1253/circj.CJ-13-1187
   Timmers S, 2011, CELL METAB, V14, P612, DOI 10.1016/j.cmet.2011.10.002
   Tinkov AA, 2018, CELL MOL LIFE SCI, V75, P1567, DOI 10.1007/s00018-018-2745-8
   TIRZIU D, 2002, TRENDS IN CARDIOVASC, V18, P299, DOI DOI 10.1016/J.TCM.2009.01.002
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Velasquez MT, 2018, METAB SYNDR RELAT D, V16, P321, DOI 10.1089/met.2017.0163
   Vona R, 2018, ADV EXP MED BIOL, V1065, P241, DOI 10.1007/978-3-319-77932-4_16
   Wang QZ, 2010, INT J VITAM NUTR RES, V80, P178, DOI 10.1024/0300-9831/a000015
   Wardman P, 2007, FREE RADICAL BIO MED, V43, P995, DOI 10.1016/j.freeradbiomed.2007.06.026
   Wautier MP, 2001, AM J PHYSIOL-ENDOC M, V280, pE685, DOI 10.1152/ajpendo.2001.280.5.E685
   WEI Y, 2002, THE JOURNAL OF BIOLO, V282, P6455, DOI DOI 10.1074/jbc.M607477200
   Wolin MS, 2009, AM J PHYSIOL-HEART C, V296, pH539, DOI 10.1152/ajpheart.01167.2008
   Wu GD, 2011, SCIENCE, V334, P105, DOI 10.1126/science.1208344
   Wu LL, 2004, CLIN CHIM ACTA, V339, P1, DOI 10.1016/j.cccn.2003.09.010
   Xia N, 2016, ARTERIOSCL THROM VAS, V36, P78, DOI 10.1161/ATVBAHA.115.306263
   Yamagishi S, 2018, CURR PHARM DESIGN, V24, P2802, DOI 10.2174/1381612824666180829110124
   Yamagishi S, 2015, CARDIOVASC DIABETOL, V14, DOI 10.1186/s12933-015-0176-5
   Youn JY, 2014, DIABETES, V63, P2344, DOI 10.2337/db13-0719
   Young JM, 2012, AM J HYPERTENS, V25, P261, DOI 10.1038/ajh.2011.209
   Zamora-Ros R, 2013, NUTR METAB CARDIOVAS, V23, P1167, DOI 10.1016/j.numecd.2012.12.008
   Zelzer S, 2011, CLIN CHIM ACTA, V412, P1345, DOI 10.1016/j.cca.2011.03.031
   ZIELONKA J, 2002, THE JOURNAL OF BIOLO, V287, P2984, DOI DOI 10.1074/JBC.M111.309062
   Zielonka J, 2018, FREE RADICAL BIO MED, V128, P3, DOI 10.1016/j.freeradbiomed.2018.03.032
   Zielonka J, 2010, FREE RADICAL BIO MED, V48, P983, DOI 10.1016/j.freeradbiomed.2010.01.028
NR 175
TC 232
Z9 246
U1 1
U2 28
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2019
VL 2019
AR 8267234
DI 10.1155/2019/8267234
PG 19
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA HZ0YC
UT WOS:000468571200001
PM 31191805
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Hong, Q
   Wang, LY
   Huang, ZY
   Feng, Z
   Cui, SY
   Fu, B
   Cai, GY
   Chen, XM
   Wu, D
AF Hong, Quan
   Wang, Liyuan
   Huang, Zhiyong
   Feng, Zhe
   Cui, Shaoyuan
   Fu, Bo
   Cai, Guangyan
   Chen, Xiangmei
   Wu, Di
TI High Concentrations of Uric Acid and Angiotensin II Act Additively to
   Produce Endothelial Injury
SO MEDIATORS OF INFLAMMATION
LA English
DT Article
ID OXIDATIVE STRESS; SUPEROXIDE-PRODUCTION; METABOLIC SYNDROME; CELL
   DYSFUNCTION; NITRIC-OXIDE; HYPERURICEMIA; HYPERTENSION; ACTIVATION;
   INCREASES; PATHWAY
AB Renin angiotensin (Ang) system (RAS) activation in metabolic syndrome (MS) patients is associated with elevated uric acid (UA) levels, resulting in endothelial system dysfunction. Our previous study demonstrated that excessive UA could cause endothelial injury through the aldose reductase (AR) pathway. This study is the first to show that a high concentration of Ang II in human umbilical vein endothelial cells (HUVECs) increases reactive oxygen species (ROS) components, including O-2 and H2O2, and further aggravates endothelial system injury induced by high UA (HUA). In a MS/hyperuricemia model, nitric oxide (NO) production was decreased, followed by a decrease in total antioxidant capacity (TAC), and the concentration of the endothelial injury marker von Willebrand factor (vWF) in the serum was increased. Treatment with catalase and polyethylene glycol covalently linked to superoxide dismutase (PEG-SOD) to individually remove H2O2 and O-2 or treatment with the AR inhibitor epalrestat decreased ROS and H2O2, increased NO levels and TAC, and reduced vWF release. Taken together, these data indicate that HUA and Ang II act additively to cause endothelial dysfunction via oxidative stress, and specific elimination of O-2 and H2O2 improves endothelial function. We provide theoretical evidence to prevent or delay endothelial injury caused by metabolic diseases.
C1 [Hong, Quan; Wang, Liyuan; Huang, Zhiyong; Feng, Zhe; Cui, Shaoyuan; Fu, Bo; Cai, Guangyan; Chen, Xiangmei; Wu, Di] Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Kidney Dis, State Key Lab Kidney Dis, Dept Nephrol,Chinese PLA Inst Nephrol, Beijing 100853, Peoples R China.
   [Wang, Liyuan] Halison Int Peace Hosp, Kidney Dept, Hengshui City 053000, Peoples R China.
   [Huang, Zhiyong] PLA, Hosp 175, Dept Nephrol, Zhangzhou 036300, Fujian, Peoples R China.
C3 Chinese People's Liberation Army General Hospital
RP Wu, D (corresponding author), Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Kidney Dis, State Key Lab Kidney Dis, Dept Nephrol,Chinese PLA Inst Nephrol, Beijing 100853, Peoples R China.
EM redhq@163.com; liyuanwang1986@163.com; hzyonghzy@163.com;
   zhezh_4025@126.com; cshaoyuan@hotmail.com; 824918563@qq.com;
   caiguangyan@sina.com; xmchen301@126.com; wudi@301hospital.com.cn
OI Hong, Quan/0000-0002-6839-7695; Cai, Guang-Yan/0000-0001-8586-6353
FU Chinese National Natural Science Foundation [81870491, 81670694];
   Fostering Fund of Chinese PLA General Hospital for National
   Distinguished Young Scholar Science Fund [2019-JQPY-002]; National Key
   Research and Development Project [2018YFE0126600]; Science and
   Technology Project of Beijing, China [Z191100006619001]
FX This work was supported by the Chinese National Natural Science
   Foundation (Nos. 81870491 and 81670694), the Fostering Fund of Chinese
   PLA General Hospital for National Distinguished Young Scholar Science
   Fund (2019-JQPY-002), the National Key Research and Development Project
   (2018YFE0126600), and the Science and Technology Project of Beijing,
   China (Z191100006619001).
CR Alper AB, 2005, HYPERTENSION, V45, P34, DOI 10.1161/01.HYP.0000150783.79172.bb
   Alvarez-Lario B, 2011, QJM-INT J MED, V104, P1015, DOI 10.1093/qjmed/hcr159
   Alvarez-Lario B, 2010, RHEUMATOLOGY, V49, P2010, DOI 10.1093/rheumatology/keq204
   AMES BN, 1981, P NATL ACAD SCI-BIOL, V78, P6858, DOI 10.1073/pnas.78.11.6858
   Bedard K, 2007, PHYSIOL REV, V87, P245, DOI 10.1152/physrev.00044.2005
   Choi HK, 2007, AM J MED, V120, P442, DOI 10.1016/j.amjmed.2006.06.040
   CONRAD CH, 1995, CIRCULATION, V91, P161, DOI 10.1161/01.CIR.91.1.161
   DAVIES KJA, 1986, BIOCHEM J, V235, P747, DOI 10.1042/bj2350747
   Dröge W, 2002, PHYSIOL REV, V82, P47, DOI 10.1152/physrev.00018.2001
   Feig DI, 2008, NEW ENGL J MED, V359, P1811, DOI 10.1056/NEJMra0800885
   Finkel T, 2000, NATURE, V408, P239, DOI 10.1038/35041687
   Gersch C, 2008, NUCLEOS NUCLEOT NUCL, V27, P967, DOI 10.1080/15257770802257952
   Gesta S, 2007, CELL, V131, P242, DOI 10.1016/j.cell.2007.10.004
   Haffner S, 2003, CIRCULATION, V108, P1541, DOI 10.1161/01.CIR.0000088845.17586.EC
   Hiraoka-Yamamoto J, 2004, CLIN EXP PHARMACOL P, V31, P107, DOI 10.1111/j.1440-1681.2004.04121.x
   Hong Q, 2015, MICROCIRCULATION, V22, P306, DOI 10.1111/micc.12200
   Hong Q, 2014, CELL PHYSIOL BIOCHEM, V34, P1675, DOI 10.1159/000366369
   Hong Q, 2012, CELL CALCIUM, V51, P402, DOI 10.1016/j.ceca.2012.01.003
   Huang ZY, 2017, CELL COMMUN SIGNAL, V15, DOI 10.1186/s12964-016-0158-6
   Hwang YC, 2001, FASEB J, V15, P243, DOI 10.1096/fj.01-0368fje
   Hwang YYC, 2004, FASEB J, V18, P1192, DOI 10.1096/fj.03-1400com
   Johnson RJ, 2009, ENDOCR REV, V30, P96, DOI 10.1210/er.2008-0033
   Johnson RJ, 2003, HYPERTENSION, V41, P1183, DOI 10.1161/01.HYP.0000069700.62727.C5
   Kang DH, 2002, J AM SOC NEPHROL, V13, P2888, DOI 10.1097/01.ASN.0000034910.58454.FD
   Khosla UM, 2005, KIDNEY INT, V67, P1739, DOI 10.1111/j.1523-1755.2005.00273.x
   Kutzing MK, 2008, J PHARMACOL EXP THER, V324, P1, DOI 10.1124/jpet.107.129031
   Lambeth JD, 2004, NAT REV IMMUNOL, V4, P181, DOI 10.1038/nri1312
   Lim Ji Hyon, 2010, Korean Circ J, V40, P314, DOI 10.4070/kcj.2010.40.7.314
   Marampon F, 2013, J HYPERTENS, V31, P1972, DOI 10.1097/HJH.0b013e3283638b32
   Nathan C, 2010, CELL, V140, DOI 10.1016/j.cell.2010.03.008
   Nishikawa T, 2000, KIDNEY INT, V58, pS26, DOI 10.1046/j.1523-1755.2000.07705.x
   Obermayr RP, 2008, J AM SOC NEPHROL, V19, P2407, DOI 10.1681/ASN.2008010080
   Pinto YM, 1998, CARDIOVASC RES, V39, P77, DOI 10.1016/S0008-6363(98)00077-7
   Powers SK, 2008, PHYSIOL REV, V88, P1243, DOI 10.1152/physrev.00031.2007
   Rajagopalan S, 1996, J CLIN INVEST, V97, P1916, DOI 10.1172/JCI118623
   Schalkwijk CG, 2005, CLIN SCI, V109, P143, DOI 10.1042/CS20050025
   Schieber M, 2014, CURR BIOL, V24, pR453, DOI 10.1016/j.cub.2014.03.034
   Touyz RM, 2003, CLIN EXP PHARMACOL P, V30, P860, DOI 10.1046/j.1440-1681.2003.03930.x
   Touyz RM, 1999, HYPERTENSION, V34, P976, DOI 10.1161/01.HYP.34.4.976
   VALLANCE P, 1989, LANCET, V2, P997
   Wen Y, 2016, ONCOTARGET, V7, P54290, DOI 10.18632/oncotarget.11091
   Yin W, 2019, BMC NEPHROL, V20, DOI 10.1186/s12882-019-1506-8
   Yu SD, 2015, CIRC J, V79, P2487, DOI 10.1253/circj.CJ-15-0283
   Zhang Y, 2014, CELL PHYSIOL BIOCHEM, V33, P479, DOI 10.1159/000358628
   Zhao M, 2018, KIDNEY DIS-BASEL, V4, P83, DOI 10.1159/000488242
NR 45
TC 14
Z9 16
U1 2
U2 10
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PD MAY 22
PY 2020
VL 2020
AR 8387654
DI 10.1155/2020/8387654
PG 11
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA LU7SE
UT WOS:000537949800001
PM 32565731
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hu, LF
   Feng, J
   Dai, XL
   Sun, Y
   Xiong, MX
   Lai, LL
   Zhong, SY
   Yi, C
   Chen, G
   Li, HH
   Yang, QF
   Kuang, Q
   Long, TT
   Zhan, JX
   Tang, TT
   Ge, CX
   Tan, J
   Xu, MX
AF Hu, Lin-Feng
   Feng, Jing
   Dai, Xianling
   Sun, Yan
   Xiong, Mingxin
   Lai, Lili
   Zhong, Shaoyu
   Yi, Chao
   Chen, Geng
   Li, Huanhuan
   Yang, Qiufeng
   Kuang, Qin
   Long, Tingting
   Zhan, Jianxia
   Tang, Tingting
   Ge, Chenxu
   Tan, Jun
   Xu, Minxuan
TI Oral flavonoid fisetin treatment protects against prolonged
   high-fat-diet-induced cardiac dysfunction by regulation of multicombined
   signaling
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Metabolic syndrome; Fisetin; Insulin resistance and dyslipidemia;
   Tnfr-1/Traf-2; Tgf-beta 1/Smads/Erk1/2
ID NF-KAPPA-B; INSULIN-RESISTANCE; OXIDATIVE STRESS; MATRIX
   METALLOPROTEINASES; CARDIOVASCULAR-DISEASE; HEART-FAILURE; IKK-BETA;
   ACTIVATION; OBESITY; INFLAMMATION
AB Excess high-fat diet (HFD) intake predisposes the occurrence of obesity-associated heart injury, but the mechanism is elusive. Fisetin (FIS), as a natural flavonoid, has potential activities to alleviate obesity-induced metabolic syndrome. However, the underlying molecular mechanisms of FIS against HFD-induced cardiac injury remain unclear. The present study was to explore the protective effects of FIS on cardiac dysfunction in HFD-fed mice. We found that FIS alleviated HFD-triggered metabolic disorder by reducing body weight, fasting blood glucose and insulin levels, and insulin resistance. Moreover, FIS supplements significantly alleviated dyslipidemia in both mouse hearts and cardiomyocytes stimulated by metabolic stress. FIS treatment abolished HFD-induced inflammatory response in heart tissues through suppressing TNF receptor-1/TNF receptor-associated factor-2 (Tnfr-1/Traf-2) signaling. Furthermore, FIS induced a strong reduction in the expression of fibrosis-related genes, contributing to the inhibition of fibrosis by inactivating transforming growth factor (Tgf)-beta 1 / Smads/Erk1/2 signaling. Collectively, these results demonstrated that FIS could be a promising therapeutic strategy for the treatment of obesity-associated cardiac injury. (C) 2019 Elsevier Inc. All rights reserved.
C1 [Hu, Lin-Feng; Feng, Jing; Dai, Xianling; Sun, Yan; Xiong, Mingxin; Lai, Lili; Zhong, Shaoyu; Yi, Chao; Chen, Geng; Li, Huanhuan; Yang, Qiufeng; Kuang, Qin; Long, Tingting; Zhan, Jianxia; Tang, Tingting; Ge, Chenxu; Tan, Jun; Xu, Minxuan] Chongqing Univ Educ, Sch Biol & Chem Engn, Chongqing Key Lab Med Resources Three Gorges Rese, Chongqing 400067, Peoples R China.
   [Hu, Lin-Feng; Feng, Jing; Dai, Xianling; Sun, Yan; Xiong, Mingxin; Lai, Lili; Zhong, Shaoyu; Yi, Chao; Chen, Geng; Li, Huanhuan; Yang, Qiufeng; Kuang, Qin; Long, Tingting; Zhan, Jianxia; Tang, Tingting] Chongqing Univ Educ, Res Ctr Brain Intellectual Promot & Dev Children, Chongqing 400067, Peoples R China.
C3 Chongqing University of Education; Chongqing University of Education
RP Ge, CX; Tan, J; Xu, MX (corresponding author), Chongqing Univ Educ, Sch Biol & Chem Engn, Chongqing Key Lab Med Resources Three Gorges Rese, Chongqing 400067, Peoples R China.
EM gecxsharon@foxmail.com; tanjunmail@126.com; minxuanxu@foxmail.com
RI hu, linfeng/C-6491-2014; Zhong, shaoyu/HNQ-9557-2023; Kuang,
   Q/G-3956-2010
OI Xu, Minxuan/0000-0002-0742-4717; , Xianling/0009-0006-9685-3834
FU National Natural Science Foundation of China (NSFC) [81703527];
   Chongqing Research Program of Basic Research and Frontier Technology
   [cstc2017jcyjAX0356, cstc2018jcyjA3686, cstc2018jcyjAX0784,
   cstc2018jcyjA1472, cstc2018jcyjAX0811, cstc2018jcyjA3533,
   KJZD-M201801601]; School-level Research Program of Chongqing University
   of Education [KY201710B, 17GZKP01]; Advanced Programs of Post-doctor of
   Chongqing [2017LY39]; Science and Technology Research Program of
   Chongqing Education Commission of China [KJQN201901608, KJQN201901615,
   KJ1601402]; Children's Research Institute of National Center for
   Schooling Development Programme [CSDP19FSO1108]; Chongqing University of
   Education [CSDP19FSO1108]
FX This work was jointly supported by (1) National Natural Science
   Foundation of China (NSFC Grant No.: 81703527); (2) Chongqing Research
   Program of Basic Research and Frontier Technology (Grant No.:
   cstc2017jcyjAX0356, cstc2018jcyjA3686, cstc2018jcyjAX0784,
   cstc2018jcyjA1472, cstc2018jcyjAX0811, cstc2018jcyjA3533 and
   KJZD-M201801601); (3) School-level Research Program of Chongqing
   University of Education (Grant No.: KY201710B and 17GZKP01); (4)
   Advanced Programs of Post-doctor of Chongqing (Grant No.: 2017LY39); (5)
   Science and Technology Research Program of Chongqing Education
   Commission of China (Grant No.: KJQN201901608, KJQN201901615, KJ1601402)
   and (6) Children's Research Institute of National Center for Schooling
   Development Programme and Chongqing University of Education (Grant No.:
   CSDP19FSO1108).
CR Adapala RK, 2013, J MOL CELL CARDIOL, V54, P45, DOI 10.1016/j.yjmcc.2012.10.016
   Akaishi T, 2008, NEUROSCI LETT, V444, P280, DOI 10.1016/j.neulet.2008.08.052
   Alhasson F, 2018, REDOX BIOL, V17, P1, DOI 10.1016/j.redox.2018.04.002
   Alvarez-Guardia D, 2011, BBA-MOL CELL BIOL L, V1811, P59, DOI 10.1016/j.bbalip.2010.11.002
   Arkan MC, 2005, NAT MED, V11, P191, DOI 10.1038/nm1185
   Bai DN, 2016, SCI REP-UK, V6, DOI 10.1038/srep22068
   Black PH, 2006, MED HYPOTHESES, V67, P879, DOI 10.1016/j.mehy.2006.04.008
   Bradley JR, 2001, ONCOGENE, V20, P6482, DOI 10.1038/sj.onc.1204788
   Cai DS, 2005, NAT MED, V11, P183, DOI 10.1038/nm1166
   Carthy JM, 2015, J CELL PHYSIOL, V230, P3084, DOI 10.1002/jcp.25049
   Ceci R, 2017, FREE RADICAL BIO MED, V103, P216, DOI 10.1016/j.freeradbiomed.2016.12.040
   Chen C, 2019, REDOX BIOL, V20, P390, DOI 10.1016/j.redox.2018.10.021
   Choe JY, 2010, INFLAMM RES, V59, P177, DOI 10.1007/s00011-009-0084-9
   Christopher BA, 2010, AM J PHYSIOL-HEART C, V299, pH1917, DOI 10.1152/ajpheart.00687.2010
   Curtis JP, 2005, ARCH INTERN MED, V165, P55, DOI 10.1001/archinte.165.1.55
   Divakaran VG, 2013, CIRC-HEART FAIL, V6, P535, DOI 10.1161/CIRCHEARTFAILURE.112.000080
   Dong B, 2018, J NUTR BIOCHEM, V62, P221, DOI 10.1016/j.jnutbio.2018.08.010
   Fan CY, 2014, J NUTR BIOCHEM, V25, P353, DOI 10.1016/j.jnutbio.2013.11.010
   Fan D, 2012, FIBROGENESIS TISSUE, V5, DOI 10.1186/1755-1536-5-15
   Frangogiannis NG, 2005, TRENDS CARDIOVAS MED, V15, P163, DOI 10.1016/j.tcm.2005.06.005
   Funakoshi-Tago M, 2011, INT IMMUNOPHARMACOL, V11, P1150, DOI 10.1016/j.intimp.2011.03.012
   Gaggini M, 2013, NUTRIENTS, V5, P1544, DOI 10.3390/nu5051544
   Gallagher EJ, 2010, MT SINAI J MED, V77, P511, DOI 10.1002/msj.20212
   Garg S, 2019, PHYTOMEDICINE, V56, P147, DOI 10.1016/j.phymed.2018.09.187
   Grech AP, 2004, IMMUNITY, V21, P629, DOI 10.1016/j.immuni.2004.09.011
   Gutierrez DA, 2009, CURR DIABETES REP, V9, P26, DOI 10.1007/s11892-009-0006-9
   Hauer J, 2005, P NATL ACAD SCI USA, V102, P2874, DOI 10.1073/pnas.0500187102
   Hobson KG, 2002, J SURG RES, V105, P4, DOI 10.1006/jsre.2002.6430
   Huang YQ, 2014, GENE, V536, P225, DOI 10.1016/j.gene.2013.12.052
   Ihm SH, 2017, J AM COLL CARDIOL, V70, pC26, DOI 10.1016/j.jacc.2017.07.088
   Jackson-Bernitsas DG, 2007, ONCOGENE, V26, P1385, DOI 10.1038/sj.onc.1209945
   Jeon TI, 2013, MOL NUTR FOOD RES, V57, P1931, DOI 10.1002/mnfr.201300071
   Jeong SM, 2012, NUTR RES PRACT, V6, P201, DOI 10.4162/nrp.2012.6.3.201
   Jia GH, 2016, NAT REV ENDOCRINOL, V12, P144, DOI 10.1038/nrendo.2015.216
   Jung CH, 2013, J NUTR BIOCHEM, V24, P1547, DOI 10.1016/j.jnutbio.2013.01.003
   Kang JH, 2010, OBESITY, V18, P780, DOI 10.1038/oby.2009.301
   Kang LL, 2016, SCI REP-UK, V6, DOI 10.1038/srep27460
   Kelly PJ, 2008, STROKE, V39, P100, DOI 10.1161/STROKEAHA.107.488189
   Khan N, 2013, ANTIOXID REDOX SIGN, V19, P151, DOI 10.1089/ars.2012.4901
   Kim HS, 2004, EXP EYE RES, V79, P263, DOI 10.1016/j.exer.2004.05.003
   Kim YM, 2015, INT J MOL MED, V36, P327, DOI 10.3892/ijmm.2015.2231
   Ko JW, 2017, FOOD CHEM TOXICOL, V106, P424, DOI 10.1016/j.fct.2017.06.016
   Koneru M, 2016, J FUNCT FOODS, V22, P588, DOI 10.1016/j.jff.2016.02.019
   Kratzer A, 2009, J LIPID RES, V50, P312, DOI 10.1194/jlr.M800376-JLR200
   Lee DCW, 2011, MOLECULES, V16, P2802, DOI 10.3390/molecules16042802
   Li J, 2014, BASIC CLIN PHARMACOL, V115, P321, DOI 10.1111/bcpt.12229
   Li K, 2016, J BIOL CHEM, V291, P18536, DOI 10.1074/jbc.M116.726836
   Li L, 2011, CARDIOVASC RES, V91, P80, DOI 10.1093/cvr/cvr067
   Liu JC, 2017, INT J CARDIOL, V228, P388, DOI 10.1016/j.ijcard.2016.11.202
   Liu W, 2017, NAT COMMUN, V8, DOI [10.1038/s41467-017-00664-8, 10.1038/s41467-017-00778-z]
   Liu Y, 2018, REDOX BIOL, V18, P211, DOI 10.1016/j.redox.2018.07.007
   Ma T, 2018, MOL BIOL REP, P1
   Madamanchi C, 2014, INT J CARDIOL, V176, P611, DOI 10.1016/j.ijcard.2014.08.007
   Matsuura K, 2009, J CLIN INVEST, V119, P2204, DOI 10.1172/JCI37456
   McCloskey CA, 2007, SURG OBES RELAT DIS, V3, P503, DOI 10.1016/j.soard.2007.05.006
   McGettigan P, 2011, PLOS MED, V8, DOI 10.1371/journal.pmed.1001098
   McLaren JE, 2011, PROG LIPID RES, V50, P331, DOI 10.1016/j.plipres.2011.04.002
   Nakai A, 2007, NAT MED, V13, P619, DOI 10.1038/nm1574
   Nishida K, 2017, CARDIOVASC RES, V113, P389, DOI 10.1093/cvr/cvx012
   Peng P, 2018, J NANOSCI NANOTECHNO, V18, P3925, DOI 10.1166/jnn.2018.15036
   Porter KE, 2009, PHARMACOL THERAPEUT, V123, P255, DOI 10.1016/j.pharmthera.2009.05.002
   Rader DJ, 2007, AM J CARDIOL, V100, p15N, DOI 10.1016/j.amjcard.2007.08.008
   Rahmouni K, 2005, HYPERTENSION, V45, P9, DOI 10.1161/01.HYP.0000151325.83008.b4
   Ramakrishnan P, 2004, IMMUNITY, V21, P477, DOI 10.1016/j.immuni.2004.08.009
   Raveney BJE, 2010, IMMUNOLOGY, V131, P340, DOI 10.1111/j.1365-2567.2010.03305.x
   Rupérez C, 2018, INT J CARDIOL, V260, P163, DOI 10.1016/j.ijcard.2018.02.109
   Salomone F, 2016, LIVER INT, V36, P5, DOI 10.1111/liv.12975
   Saltiel AR, 2017, J CLIN INVEST, V127, P1, DOI [10.1172/JCI92035, 10.1172/jci92035]
   Saltiel AR, 2001, NATURE, V414, P799, DOI 10.1038/414799a
   Sapieha P, 2012, NUTR DIABETES, V2, DOI 10.1038/nutd.2012.10
   Sarafidis PA, 2008, CURR OPIN NEPHROL HY, V17, P450, DOI 10.1097/MNH.0b013e328305b994
   Semple RK, 2009, J CLIN INVEST, V119, P315, DOI 10.1172/JCI37432
   Sengupta B, 2004, FEBS LETT, V570, P77, DOI 10.1016/j.febslet.2004.06.027
   Siti HN, 2015, VASC PHARMACOL, V71, P40, DOI 10.1016/j.vph.2015.03.005
   Spinale FG, 2007, PHYSIOL REV, V87, P1285, DOI 10.1152/physrev.00012.2007
   Takeda N, 2010, J CLIN INVEST, V120, P254, DOI 10.1172/JCI40295
   Tang HY, 2016, CELL STRESS CHAPERON, V21, P239, DOI 10.1007/s12192-015-0654-4
   Thum T, 2008, NATURE, V456, P980, DOI 10.1038/nature07511
   Tian YQ, 2012, J CARDIOVASC PHARM T, V17, P223, DOI 10.1177/1074248411423022
   Valenzuela R, 2017, FOOD FUNCT, V8, P1526, DOI [10.1039/c7fo00090a, 10.1039/C7FO00090A]
   Varga ZV, 2015, BBA-MOL BASIS DIS, V1852, P232, DOI 10.1016/j.bbadis.2014.06.030
   von Lueder TG, 2015, CIRC-HEART FAIL, V8, P71, DOI 10.1161/CIRCHEARTFAILURE.114.001785
   Wajant H, 2001, INT J BIOCHEM CELL B, V33, P19, DOI 10.1016/S1357-2725(00)00064-9
   Wang W, 2013, BRIT J PHARMACOL, V169, P1352, DOI 10.1111/bph.12226
   Wang YQ, 2011, CONNECT TISSUE RES, V52, P218, DOI 10.3109/03008207.2010.516849
   Wollert Kai C, 2012, Curr Heart Fail Rep, V9, P337, DOI 10.1007/s11897-012-0113-9
   Wu LJ, 2018, AGING CELL, V17, DOI 10.1111/acel.12763
   Xu MX, 2019, FREE RADICAL BIO MED, V130, P542, DOI 10.1016/j.freeradbiomed.2018.11.016
   Xu MX, 2018, ADV HEALTHC MATER, V7, DOI 10.1002/adhm.201800427
   Xu MX, 2019, J FUNCT FOODS, V53, P7, DOI 10.1016/j.jff.2018.12.007
   Yamato M, 2012, MOL CELL BIOCHEM, V359, P161, DOI 10.1007/s11010-011-1010-3
   Zhang H, 2017, MOL MED REP, V16, P2295, DOI 10.3892/mmr.2017.6810
   Zheng LT, 2008, INT IMMUNOPHARMACOL, V8, P484, DOI 10.1016/j.intimp.2007.12.012
   Zhu LJ, 2010, CYTOKINE, V49, P201, DOI 10.1016/j.cyto.2009.10.004
NR 94
TC 19
Z9 19
U1 0
U2 24
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD MAR
PY 2020
VL 77
AR 108253
DI 10.1016/j.jnutbio.2019.108253
PG 15
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA KQ4GN
UT WOS:000516883200007
PM 31835147
DA 2025-06-11
ER

PT J
AU Hosoi, T
   Ozawa, K
AF Hosoi, Toru
   Ozawa, Koichiro
TI Possible Pharmacological Approach Targeting Endoplasmic Reticulum Stress
   to Ameliorate Leptin Resistance in Obesity
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE endoplasmic reticulum stress; obesity; leptin; leptin resistance; STAT3
ID VASCULAR ENDOTHELIAL-CELLS; UNFOLDED PROTEIN RESPONSE;
   TYROSINE-PHOSPHATASE 1B; BLOOD-BRAIN-BARRIER; CONNECTS ER STRESS;
   ENERGY-BALANCE; RECEPTOR; EXPRESSION; NEURONS; MICE
AB Obesity is associated with metabolic syndrome, such as diabetes, hypertension, and hyperlipidemia. Therefore, drug development for the treatment of obesity is needed. Leptin is an anti-obesity hormone that inhibits food intake and increases energy metabolism, and, as such, treatments involving leptin were expected to be beneficial for obesity; however, since most obese patients are in a state of leptin resistance, these treatments may not be useful. Therefore, the amelioration of leptin resistance has recently been attracting interest as a treatment for obesity. The mechanisms underlying the development of leptin resistance need to be elucidated in more detail. Endoplasmic reticulum (ER) stress was recently suggested to be involved in the pathogenesis of leptin resistance. The molecular mechanisms responsible for leptin resistance and possible pharmacological treatments for obesity have been discussed herein, with a focus on ER stress.
C1 [Hosoi, Toru; Ozawa, Koichiro] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Pharmacotherapy, Hiroshima, Japan.
C3 Hiroshima University
RP Hosoi, T; Ozawa, K (corresponding author), Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Pharmacotherapy, Hiroshima, Japan.
EM toruh@hiroshima-u.ac.jp; ozawak@hiroshima-u.ac.jp
RI Hosoi, Toru/A-7954-2018
FU Ministry of Education, Science, Sports and Culture, Japan; Takeda
   Science Foundation; Grants-in-Aid for Scientific Research [16K08271,
   15K08025] Funding Source: KAKEN
FX This study was supported by a Grant-in-Aid for Scientific Research from
   the Ministry of Education, Science, Sports and Culture, Japan and the
   Takeda Science Foundation.
CR Banks WA, 2001, CURR PHARM DESIGN, V7, P125, DOI 10.2174/1381612013398310
   Bates SH, 2003, NATURE, V421, P856, DOI 10.1038/nature01388
   Bence KK, 2006, NAT MED, V12, P917, DOI 10.1038/nm1435
   Bjorbaek C, 1998, MOL CELL, V1, P619, DOI 10.1016/S1097-2765(00)80062-3
   Bjorbæk C, 2000, J BIOL CHEM, V275, P40649, DOI 10.1074/jbc.M007577200
   Caro JF, 1996, LANCET, V348, P159, DOI 10.1016/S0140-6736(96)03173-X
   Cheng A, 2002, DEV CELL, V2, P497, DOI 10.1016/S1534-5807(02)00149-1
   Endo TA, 1997, NATURE, V387, P921, DOI 10.1038/43213
   Fei H, 1997, P NATL ACAD SCI USA, V94, P7001, DOI 10.1073/pnas.94.13.7001
   FREDERICH RC, 1995, NAT MED, V1, P1311, DOI 10.1038/nm1295-1311
   Friedman JM, 2003, SCIENCE, V299, P856, DOI 10.1126/science.1079856
   Golden PL, 1997, J CLIN INVEST, V99, P14, DOI 10.1172/JCI119125
   Gorska E, 2010, EUR J MED RES, V15, P50
   Hanner M, 1996, P NATL ACAD SCI USA, V93, P8072, DOI 10.1073/pnas.93.15.8072
   Hayashi T, 2007, CELL, V131, P596, DOI 10.1016/j.cell.2007.08.036
   Hosoi T, 2002, ENDOCRINOLOGY, V143, P3498, DOI 10.1210/en.2002-220077
   Hosoi T, 2002, BRAIN RES, V949, P139, DOI 10.1016/S0006-8993(02)02974-8
   Hosoi T, 2002, BIOCHEM BIOPH RES CO, V294, P215, DOI 10.1016/S0006-291X(02)00486-2
   Hosoi T, 2008, MOL PHARMACOL, V74, P1610, DOI 10.1124/mol.108.050070
   Hosoi T, 2014, NEUROSCI LETT, V569, P23, DOI 10.1016/j.neulet.2014.03.053
   Hosoi T, 2014, EMBO MOL MED, V6, P335, DOI 10.1002/emmm.201303227
   Hosoi Toru, 2012, Front Endocrinol (Lausanne), V3, P12, DOI 10.3389/fendo.2012.00012
   Hosoi T, 2010, NEUROCHEM INT, V56, P216, DOI 10.1016/j.neuint.2009.12.005
   Hosoi T, 2010, CLIN SCI, V118, P19, DOI 10.1042/CS20080680
   Karaskov E, 2006, ENDOCRINOLOGY, V147, P3398, DOI 10.1210/en.2005-1494
   Kokame K, 1996, J BIOL CHEM, V271, P29659, DOI 10.1074/jbc.271.47.29659
   Liu JL, 2015, CELL, V161, P999, DOI 10.1016/j.cell.2015.05.011
   Mercer JG, 1996, FEBS LETT, V387, P113, DOI 10.1016/0014-5793(96)00473-5
   Morrison CD, 2007, ENDOCRINOLOGY, V148, P433, DOI 10.1210/en.2006-0672
   Naka T, 1997, NATURE, V387, P924, DOI 10.1038/43219
   Narin F, 2005, ANN SAUDI MED, V25, P209, DOI 10.5144/0256-4947.2005.209
   Omi T, 2014, CELL DEATH DIS, V5, DOI 10.1038/cddis.2014.301
   Outinen PA, 1999, BLOOD, V94, P959, DOI 10.1182/blood.V94.3.959.415k20_959_967
   Ozcan L, 2009, CELL METAB, V9, P35, DOI 10.1016/j.cmet.2008.12.004
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Picardi PK, 2008, ENDOCRINOLOGY, V149, P3870, DOI 10.1210/en.2007-1506
   Ron D, 2007, NAT REV MOL CELL BIO, V8, P519, DOI 10.1038/nrm2199
   Schneeberger M, 2013, CELL, V155, P172, DOI 10.1016/j.cell.2013.09.003
   Starr R, 1997, NATURE, V387, P917, DOI 10.1038/43206
   VanHeek M, 1997, J CLIN INVEST, V99, P385, DOI 10.1172/JCI119171
   Walter P, 2011, SCIENCE, V334, P1081, DOI 10.1126/science.1209038
   Wang M, 2014, NAT REV CANCER, V14, P581, DOI 10.1038/nrc3800
   Welch WJ, 1996, CELL STRESS CHAPERON, V1, P109, DOI 10.1379/1466-1268(1996)001<0109:IOMACC>2.3.CO;2
   Williams KW, 2014, CELL METAB, V20, P471, DOI 10.1016/j.cmet.2014.06.002
   YOSHIMURA A, 1995, EMBO J, V14, P2816, DOI 10.1002/j.1460-2075.1995.tb07281.x
   Zabolotny JM, 2002, DEV CELL, V2, P489, DOI 10.1016/S1534-5807(02)00148-X
   ZHANG YY, 1994, NATURE, V372, P425, DOI 10.1038/372425a0
NR 47
TC 12
Z9 13
U1 0
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
   SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JUN 8
PY 2016
VL 7
AR 59
DI 10.3389/fendo.2016.00059
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DP5CE
UT WOS:000378512800001
PM 27375555
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wang, Y
   Fouret, G
   Bonafos, B
   Blachnio-Zabielska, A
   Leroy, T
   Crouzier, D
   Barea, B
   Gaillet, S
   Moro, C
   Lecomte, J
   Coudray, C
   Feillet-Coudray, C
AF Wang, Yang
   Fouret, Gilles
   Bonafos, Beatrice
   Blachnio-Zabielska, Agnieszka
   Leroy, Thibault
   Crouzier, David
   Barea, Bruno
   Gaillet, Sylvie
   Moro, Cedric
   Lecomte, Jerome
   Coudray, Charles
   Feillet-Coudray, Christine
TI Long-term follow-up of muscle lipid accumulation, mitochondrial activity
   and oxidative stress and their relationship with impaired glucose
   homeostasis in high fat high fructose diet-fed rats
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Free radicals; High fat/high fructose diet; Impaired glucose
   homeostasis; Mitochondrial function; Muscle lipid composition; Muscle
   metabolism; Oxidative stress
ID STEAROYL-COA DESATURASE; INSULIN-RESISTANCE; SKELETAL-MUSCLE; METABOLIC
   SYNDROME; RESPIRATORY-CHAIN; ACID-COMPOSITION; INDUCED OBESITY;
   SENSITIVITY; LIVER; PHOSPHATIDYLCHOLINE
AB Metabolic syndrome components, including obesity, dyslipidemia and impaired glucose homeostasis, become a major public health issue. Muscles play a predominant role in insulin-mediated glucose uptake, and high fat diets may negatively affect muscle function and homeostasis. This work aimed to study the time-course of muscle lipid accumulation, oxidative stress and mitochondrial dysfunction and their association to impaired glucose homeostasis in rats fed an obesogenic diet. Male Wistar rats were fed with a standard or a high fat/high fructose (HFHFr) diet and sacrificed on 4, 8, 12, 16, 20 weeks. Rats fed the HFHFr diet developed mild overweight, increased liver and adipose tissue weights and glucose intolerance. The impaired glucose homeostasis increased gradually with the HFHFr diet to become significant on the 12th and 16th weeks of diet. In parallel, the muscle lipid composition showed an increase in the saturated fatty acids and the monounsaturated fatty acids with a marked decrease in the polyunsaturated fatty acids. The HFHFr diet also increased muscle contents of both diacylglycerols and Ceramides. Surprisingly, HFHFr diet did not induce major muscle mitochondrial dysfunction or oxidative stress. These results indicate that muscle lipid alterations, as well as impaired glucose homeostasis occur as early as the 8th week of HFHFr diet, increase to reach a plateau around the 12th-16th weeks of diet, and then attenuate towards the end of study. At these diet treatment durations, muscle mitochondrial activity and oxidative stress remained unchanged and do not seem to have a major role in the observed impaired glucose homeostasis. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Wang, Yang; Fouret, Gilles; Bonafos, Beatrice; Gaillet, Sylvie; Coudray, Charles; Feillet-Coudray, Christine] Univ Montpellier, DMEM, INRA, Montpellier, France.
   [Wang, Yang] Zhejiang Univ, Coll Anim Sci, Hangzhou, Zhejiang, Peoples R China.
   [Blachnio-Zabielska, Agnieszka] Med Univ Bialystok, Dept Physiol, Bialystok, Poland.
   [Blachnio-Zabielska, Agnieszka] Med Univ Bialystok, Hyg Epidemiol Metab Disorders Dept, Bialystok, Poland.
   [Leroy, Thibault; Moro, Cedric] INSERM, UMR1048, Inst Metab & Cardiovasc Dis, Toulouse, France.
   [Crouzier, David] Inst Rech Biomed Armees, Paris, France.
   [Barea, Bruno; Lecomte, Jerome] CIRAD, IATE, Montpellier, France.
C3 INRAE; Universite de Montpellier; Zhejiang University; Medical
   University of Bialystok; Medical University of Bialystok; Universite de
   Toulouse; Universite Toulouse III - Paul Sabatier; Institut National de
   la Sante et de la Recherche Medicale (Inserm); CIRAD; Universite de
   Montpellier
RP Feillet-Coudray, C (corresponding author), INRA UMR 866, F-34060 Montpellier, France.
EM christine.coudray@inra.fr
RI Moro, Cedric/N-5754-2017; Blachnio-Zabielsk, Agnieszka/A-4879-2018;
   COUDRAY, Charles/AGG-4757-2022
OI Blachnio-Zabielska, Agnieszka/0000-0002-8055-0576; Moro,
   Cedric/0000-0003-4294-0597
FU PhD program of the China Scholarship Council
FX Yang Wang thanks for the support from PhD program of the China
   Scholarship Council.
CR Abbott SK, 2009, BR J NUTR, P1
   Ahn J, 2014, J NUTR BIOCHEM, V25, P1026, DOI 10.1016/j.jnutbio.2014.05.006
   Aoun M, 2012, J BIOENERG BIOMEMBR, V44, P439, DOI 10.1007/s10863-012-9448-x
   Aoun M, 2012, BRIT J NUTR, V107, P647, DOI 10.1017/S000711451100331X
   Bai JF, 2015, INT J CLIN EXP PATHO, V8, P13193
   Baracca A, 2003, BBA-BIOENERGETICS, V1606, P137, DOI 10.1016/S0005-2728(03)00110-5
   Barja G, 2002, J BIOENERG BIOMEMBR, V34, P227, DOI 10.1023/A:1016039604958
   Barness LA, 2007, AM J MED GENET A, V143A, P3016, DOI 10.1002/ajmg.a.32035
   BEERS RF, 1952, J BIOL CHEM, V195, P133
   Blachnio-Zabielska AU, 2016, CELL PHYSIOL BIOCHEM, V40, P1207, DOI 10.1159/000453174
   Blachnio-Zabielska AU, 2013, J LIPID RES, V54, P1705, DOI 10.1194/jlr.D035006
   Blachnio-Zabielska AU, 2012, RAPID COMMUN MASS SP, V26, P1134, DOI 10.1002/rcm.6216
   BORKMAN M, 1993, NEW ENGL J MED, V328, P238, DOI 10.1056/NEJM199301283280404
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Clayton PT, 2001, J CLIN INVEST, V108, P457
   Clore JN, 1998, AM J PHYSIOL-ENDOC M, V275, pE665, DOI 10.1152/ajpendo.1998.275.4.E665
   Coudray C, 2016, BRIT J NUTR, V115, P1155, DOI 10.1017/S0007114515005528
   Das N, 2017, FOOD FUNCT, V8, P1577, DOI 10.1039/c6fo01326k
   DeFronzo RA, 2009, DIABETES CARE, V32, pS157, DOI 10.2337/dc09-S302
   Dobrzyn A, 2005, PROSTAG LEUKOTR ESS, V73, P35, DOI 10.1016/j.plefa.2005.04.011
   Dobrzyn P, 2010, BBA-BIOENERGETICS, V1797, P1189, DOI 10.1016/j.bbabio.2010.02.007
   Faure P., 1995, P237
   Feillet-Coudray C, 2009, FREE RADICAL BIO MED, V46, P624, DOI 10.1016/j.freeradbiomed.2008.11.020
   Feillet-Coudray C, 2014, FREE RADICAL RES, V48, P1232, DOI 10.3109/10715762.2014.945079
   Feillet-Coudray C, 2013, BRIT J NUTR, V110, P1789, DOI 10.1017/S0007114513001311
   Finck BN, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/104132
   FLOHE L, 1984, METHOD ENZYMOL, V105, P114
   Fouret G, 2018, BRIT J NUTR, V119, P368, DOI [10.1017/S0007114517003713, 10.1017/s0007114517003713]
   Funai K, 2016, DIABETES, V65, P358, DOI 10.2337/db15-0659
   GRIFFITH OW, 1980, ANAL BIOCHEM, V106, P207, DOI 10.1016/0003-2697(80)90139-6
   Holland WL, 2008, ENDOCR REV, V29, P381, DOI 10.1210/er.2007-0025
   Holloszy JO, 2013, DIABETES, V62, P1036, DOI 10.2337/db12-1107
   Janssen AJM, 2007, CLIN CHEM, V53, P729, DOI 10.1373/clinchem.2006.078873
   JENKINS DJA, 1985, AM J CLIN NUTR, V42, P604, DOI 10.1093/ajcn/42.4.604
   Johnson AR, 2016, BIOCHEM BIOPH RES CO, V473, P545, DOI 10.1016/j.bbrc.2016.03.113
   Jornayvaz FR, 2012, CELL METAB, V15, P574, DOI 10.1016/j.cmet.2012.03.005
   Keung W, 2013, DIABETES, V62, P711, DOI 10.2337/db12-0259
   Kraegen EW, 2008, P NATL ACAD SCI USA, V105, P7627, DOI 10.1073/pnas.0803901105
   Lark D S, 2012, Int J Obes Suppl, V2, pS31
   Larsen S, 2012, J PHYSIOL-LONDON, V590, P3349, DOI 10.1113/jphysiol.2012.230185
   Lee JS, 2006, J APPL PHYSIOL, V100, P1467, DOI 10.1152/japplphysiol.01438.2005
   LEPAGE G, 1986, J LIPID RES, V27, P114
   Lionetti L, 2007, INT J OBESITY, V31, P1596, DOI 10.1038/sj.ijo.0803636
   MARKLUND S, 1976, J BIOL CHEM, V251, P7504
   Martins AR, 2018, J NUTR BIOCHEM, V55, P76, DOI 10.1016/j.jnutbio.2017.11.012
   Méndez L, 2014, J NUTR BIOCHEM, V25, P1243, DOI 10.1016/j.jnutbio.2014.06.014
   Montgomery MK, 2015, ENDOCR CONNECT, V4, DOI 10.1530/EC-14-0092
   Newsom SA, 2016, J APPL PHYSIOL, V120, P1355, DOI 10.1152/japplphysiol.00664.2015
   Pagadala M, 2012, TRENDS ENDOCRIN MET, V23, P365, DOI 10.1016/j.tem.2012.04.005
   Pirozzi C, 2016, J NUTR BIOCHEM, V30, P108, DOI 10.1016/j.jnutbio.2015.12.004
   Putti R, 2016, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00426
   Riccardi G, 2004, CLIN NUTR, V23, P447, DOI 10.1016/j.clnu.2004.02.006
   Riccardi G, 2000, BRIT J NUTR, V83, pS143
   Risérus U, 2008, CURR OPIN CLIN NUTR, V11, P100, DOI 10.1097/MCO.0b013e3282f52708
   RUSTIN P, 1994, CLIN CHIM ACTA, V228, P35, DOI 10.1016/0009-8981(94)90055-8
   Srere P.A., 1969, Methods in Enzymology, V13, P3, DOI DOI 10.1016/0076-6879(69)13005-0
   Summers SA, 2006, PROG LIPID RES, V45, P42, DOI 10.1016/j.plipres.2005.11.002
   SUNDERMAN FW, 1985, ANN CLIN LAB SCI, V15, P229
   Tonks KT, 2016, OBESITY, V24, P908, DOI 10.1002/oby.21448
   Turrens JF, 2003, J PHYSIOL-LONDON, V552, P335, DOI 10.1113/jphysiol.2003.049478
   Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
   van Herpen NA, 2008, PHYSIOL BEHAV, V94, P231, DOI 10.1016/j.physbeh.2007.11.049
   Victor VM, 2011, CURR PHARM DESIGN, V17, P3947, DOI 10.2174/138161211798764915
   Warensjö E, 2008, NUTR METAB CARDIOVAS, V18, P683, DOI 10.1016/j.numecd.2007.11.002
   Wharton D. C., 1967, METHOD ENZYMOL, P245, DOI [10.1016/0076-6879(67)10048-7, DOI 10.1016/0076-6879(67)10048-7]
NR 65
TC 9
Z9 10
U1 0
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD FEB
PY 2019
VL 64
BP 182
EP 197
DI 10.1016/j.jnutbio.2018.10.021
PG 16
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA HL9RZ
UT WOS:000459081600019
PM 30530258
OA Green Published, Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Manolagas, SC
   Almeida, M
AF Manolagas, Stavros C.
   Almeida, Maria
TI Gone with the Wnts:: β-catenin, T-cell factor, forkhead box O, and
   oxidative stress in age-dependent diseases of bone, lipid, and glucose
   metabolism
SO MOLECULAR ENDOCRINOLOGY
LA English
DT Review
ID RECEPTOR-RELATED PROTEIN-5; TRANSCRIPTION FACTOR FOXO3A; BODY-MASS
   INDEX; WNT/BETA-CATENIN; MINERAL DENSITY; DIFFERENTIATED OSTEOBLASTS;
   NEGATIVE REGULATOR; DIABETES-MELLITUS; REDOX REGULATION; FRACTURE RISK
AB The Wnt/beta-catenin signaling pathway affects several biological processes ranging from embryonic development, patterning, and postembryonic stem cell fate, to bone formation and insulin secretion in adulthood. beta-Catenin mediates canonical Wnt signaling by binding to and activating members of the T-cell factor ( TCF) transcription factor family. Similar to the Wnt/beta-catenin pathway, oxidative stress influences fundamental cellular processes including stem cell fate and has been linked to aging and the development of age-related diseases. However, the molecular details of the pathogenetic effects of oxidative stress on the homeostasis of many different tissues remain unclear. beta-Catenin has been recently implicated as a pivotal molecule in defense against oxidative stress by serving as a cofactor of the forkhead box O ( FOXO) transcription factors. In addition, it has been shown that oxidative stress is a pivotal pathogenetic factor of age-related bone loss and strength in mice, leading to, among other changes, a decrease in osteoblast number and bone formation. These particular cellular changes evidently result from diversion of the limited pool of beta-catenin from TCF- to FOXO-mediated transcription in osteoblastic cells. Fascinatingly, attenuation of Wnt-mediated transcription, resulting from an autosomal-dominant missense mutation in LRP6, a coreceptor for the Wnt-signaling pathway, has been linked recently genetically not only to premature osteoporosis, but also to coronary artery disease as well as several features of the metabolic syndrome including hyperlipidemia, hypertension, and diabetes, but not obesity. In this minireview, we highlight evidence linking the age-associated oxidative stress with FOXOs, Wnt/beta-catenin signaling, osteoblastogenesis, adipogenesis, osteoporosis, and several features of the metabolic syndrome. We hypothesize that antagonism of Wnt signaling by oxidative stress with increasing age may be a common molecular mechanism contributing to the development not only of involutional osteoporosis, but several pathologies such as atherosclerosis, insulin resistance, and hyperlipidemia, all of which become more prevalent with advancing age.
C1 Univ Arkansas Med Sci, Div Endocrinol & Metab, Little Rock, AR 72205 USA.
   Univ Arkansas Med Sci, Ctr Osteoporosis & Metab Bone Dis, Dept Med, Little Rock, AR 72205 USA.
   Cent Arkansas Vet Hlth Care Syst, Little Rock, AR 72205 USA.
C3 University of Arkansas System; University of Arkansas Medical Sciences;
   University of Arkansas System; University of Arkansas Medical Sciences;
   US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Central Arkansas Veterans Healthcare System
RP Manolagas, SC (corresponding author), 4301 W Markham 587, Little Rock, AR 72205 USA.
EM manolagasstavros@uams.edu
OI Almeida, Maria/0000-0002-6722-9200
FU NIAMS NIH HHS [R01AR51187] Funding Source: Medline; NIA NIH HHS
   [P01AG13918] Funding Source: Medline
CR Almeida M, 2005, J BIOL CHEM, V280, P41342, DOI 10.1074/jbc.M502168200
   Almeida M, 2007, J BIOL CHEM, V282, P27285, DOI 10.1074/jbc.M702810200
   Almeida M, 2007, J BIOL CHEM, V282, P27298, DOI 10.1074/jbc.M702811200
   Babij P, 2003, J BONE MINER RES, V18, P960, DOI 10.1359/jbmr.2003.18.6.960
   Balemans W, 2001, HUM MOL GENET, V10, P537, DOI 10.1093/hmg/10.5.537
   BARRETTCONNOR E, 1992, JAMA-J AM MED ASSOC, V268, P3333
   Bienz M, 2003, NAT CELL BIOL, V5, P179, DOI 10.1038/ncb0303-179
   Bodine PVN, 2004, MOL ENDOCRINOL, V18, P1222, DOI 10.1210/me.2003-0498
   Boyden LM, 2002, NEW ENGL J MED, V346, P1513, DOI 10.1056/NEJMoa013444
   Brunet A, 2004, SCIENCE, V303, P2011, DOI 10.1126/science.1094637
   Brunkow ME, 2001, AM J HUM GENET, V68, P577, DOI 10.1086/318811
   Burgering BMT, 2002, TRENDS BIOCHEM SCI, V27, P352, DOI 10.1016/S0968-0004(02)02113-8
   Camici GG, 2007, P NATL ACAD SCI USA, V104, P5217, DOI 10.1073/pnas.0609656104
   De Laet C, 2005, OSTEOPOROSIS INT, V16, P1330, DOI 10.1007/s00198-005-1863-y
   de Liefde II, 2005, OSTEOPOROSIS INT, V16, P1713, DOI 10.1007/s00198-005-1909-1
   Dickinson DA, 2002, ANN NY ACAD SCI, V973, P488, DOI 10.1111/j.1749-6632.2002.tb04690.x
   Essers MAG, 2004, EMBO J, V23, P4802, DOI 10.1038/sj.emboj.7600476
   Essers MAG, 2005, SCIENCE, V308, P1181, DOI 10.1126/science.1109083
   Farhat GN, 2006, J BONE MINER RES, V21, P1839, DOI 10.1359/JBMR.060903
   FELSON DT, 1993, J BONE MINER RES, V8, P567, DOI 10.1002/jbmr.5650080507
   Finkel T, 2000, NATURE, V408, P239, DOI 10.1038/35041687
   Fujino T, 2003, P NATL ACAD SCI USA, V100, P229, DOI 10.1073/pnas.0133792100
   Giorgio M, 2005, CELL, V122, P221, DOI 10.1016/j.cell.2005.05.011
   Glass DA, 2005, DEV CELL, V8, P751, DOI 10.1016/j.devcel.2005.02.017
   Gong YQ, 2001, CELL, V107, P513, DOI 10.1016/S0092-8674(01)00571-2
   Grant SFA, 2006, NAT GENET, V38, P320, DOI 10.1038/ng1732
   Hartmann C, 2006, TRENDS CELL BIOL, V16, P151, DOI 10.1016/j.tcb.2006.01.001
   He X, 2004, DEVELOPMENT, V131, P1663, DOI 10.1242/dev.01117
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Holmen SL, 2004, J BONE MINER RES, V19, P2033, DOI 10.1359/JBMR.040907
   Holmen SL, 2005, J BIOL CHEM, V280, P21162, DOI 10.1074/jbc.M501900200
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   HUI SL, 1988, J CLIN INVEST, V81, P1804, DOI 10.1172/JCI113523
   Jagger CJ, 2005, ENDOCRINOLOGY, V146, P113, DOI 10.1210/en.2004-1058
   Jilka RL, 1996, J CLIN INVEST, V97, P1732, DOI 10.1172/JCI118600
   Kajkenova O, 1997, J BONE MINER RES, V12, P1772, DOI 10.1359/jbmr.1997.12.11.1772
   Kamei Y, 2004, J BIOL CHEM, V279, P41114, DOI 10.1074/jbc.M400674200
   Kaneto H, 1999, DIABETES, V48, P2398, DOI 10.2337/diabetes.48.12.2398
   Kaneto H, 2004, NAT MED, V10, P1128, DOI 10.1038/nm1111
   Kato M, 2002, J CELL BIOL, V157, P303, DOI 10.1083/jcb.200201089
   Kenyon C, 2005, CELL, V120, P449, DOI 10.1016/j.cell.2005.02.002
   Kenyon C, 2001, CELL, V105, P165, DOI 10.1016/S0092-8674(01)00306-3
   Kitamura T, 2002, J CLIN INVEST, V110, P1839, DOI 10.1172/JCI200216857
   Kolpakova E, 2005, DEV CELL, V8, P626, DOI 10.1016/j.devcel.2005.04.008
   Kops GJPL, 2002, NATURE, V419, P316, DOI 10.1038/nature01036
   Kops GJPL, 2002, MOL CELL BIOL, V22, P2025, DOI 10.1128/MCB.22.7.2025-2036.2002
   KRAKAUER JC, 1995, DIABETES, V44, P775, DOI 10.2337/diabetes.44.7.775
   Lean JM, 2003, J CLIN INVEST, V112, P915, DOI 10.1172/JCI200318859
   Li XF, 2005, J BIOL CHEM, V280, P19883, DOI 10.1074/jbc.M413274200
   Little RD, 2002, AM J HUM GENET, V70, P11, DOI 10.1086/338450
   Liu CM, 2002, CELL, V108, P837, DOI 10.1016/S0092-8674(02)00685-2
   Mani A, 2007, SCIENCE, V315, P1278, DOI 10.1126/science.1136370
   Manolagas SC, 2000, ENDOCR REV, V21, P115, DOI 10.1210/er.21.2.115
   Marcovitz PA, 2005, AM J CARDIOL, V96, P1059, DOI 10.1016/j.amjcard.2005.06.034
   Medema RH, 2000, NATURE, V404, P782, DOI 10.1038/35008115
   Migliaccio E, 1999, NATURE, V402, P309, DOI 10.1038/46311
   Moon RT, 2002, SCIENCE, V296, P1644, DOI 10.1126/science.1071549
   Nakai J, 2002, NAT GENET, V32, P245, DOI 10.1038/ng890
   Nakamura H, 1997, ANNU REV IMMUNOL, V15, P351, DOI 10.1146/annurev.immunol.15.1.351
   Nemoto S, 2002, SCIENCE, V295, P2450, DOI 10.1126/science.1069004
   Niehrs C, 2006, ONCOGENE, V25, P7469, DOI 10.1038/sj.onc.1210054
   Nusse R, 2003, DEVELOPMENT, V130, P5297, DOI 10.1242/dev.00821
   O'Brien CA, 2004, ENDOCRINOLOGY, V145, P1835, DOI 10.1210/en.2003-0990
   Owen KR, 2007, CURR OPIN GENET DEV, V17, P239, DOI 10.1016/j.gde.2007.04.003
   Qiu SJ, 2003, J BONE MINER RES, V18, P1657, DOI 10.1359/jbmr.2003.18.9.1657
   QUARRIE JK, 2004, SCI AGING KNOWLEDGE, pRE5
   Ramaswamy S, 2002, CANCER CELL, V2, P81, DOI 10.1016/S1535-6108(02)00086-7
   RIGGS BL, 2005, P 27 ANN M AM SOC BO
   Robertson RP, 2004, J BIOL CHEM, V279, P42351, DOI 10.1074/jbc.R400019200
   Robinson JA, 2006, J BIOL CHEM, V281, P31720, DOI 10.1074/jbc.M602308200
   Rosen ED, 2006, NAT REV MOL CELL BIO, V7, P885, DOI 10.1038/nrm2066
   Ruel L, 1999, J BIOL CHEM, V274, P21790, DOI 10.1074/jbc.274.31.21790
   Rulifson IC, 2007, P NATL ACAD SCI USA, V104, P6247, DOI 10.1073/pnas.0701509104
   Schulz E, 2004, J CLIN ENDOCR METAB, V89, P4246, DOI 10.1210/jc.2003-030964
   Schwartz AV, 2005, J BONE MINER RES, V20, P596, DOI 10.1359/JBMR.041219
   Schwartz AV, 2001, J CLIN ENDOCR METAB, V86, P32, DOI 10.1210/jc.86.1.32
   Scott LJ, 2007, SCIENCE, V316, P1341, DOI 10.1126/science.1142382
   Sevetson B, 2004, J BIOL CHEM, V279, P13849, DOI 10.1074/jbc.M306249200
   Smith U, 2007, DIABETOLOGIA, V50, P5, DOI 10.1007/s00125-006-0521-z
   Staal F J, 2000, Hematol J, V1, P3, DOI 10.1038/sj.thj.6200001
   Tamai K, 2000, NATURE, V407, P530, DOI 10.1038/35035117
   Tanaka Y, 1999, P NATL ACAD SCI USA, V96, P10857, DOI 10.1073/pnas.96.19.10857
   Tothova Z, 2007, CELL, V128, P325, DOI 10.1016/j.cell.2007.01.003
   Tran H, 2002, SCIENCE, V296, P530, DOI 10.1126/science.1068712
   Trinei M, 2002, ONCOGENE, V21, P3872, DOI 10.1038/sj.onc.1205513
   Tuma R, 2001, Sci Aging Knowledge Environ, V2001, poa5
   Tyner SD, 2002, NATURE, V415, P45, DOI 10.1038/415045a
   van Bezooijen RL, 2004, J EXP MED, V199, P805, DOI 10.1084/jem.20031454
   VANDAELE PLA, 1995, ANN INTERN MED, V122, P409, DOI 10.7326/0003-4819-122-6-199503150-00002
   Veeman MT, 2003, DEV CELL, V5, P367, DOI 10.1016/S1534-5807(03)00266-1
   von Muhlen D, 2007, OSTEOPOROSIS INT, V18, P1337, DOI 10.1007/s00198-007-0385-1
   Wang MC, 2005, CELL, V121, P115, DOI 10.1016/j.cell.2005.02.030
   WARMINGTON K, 2004, P 26 ANN M DENS IMPL
   Willert K, 2003, NATURE, V423, P448, DOI 10.1038/nature01611
   Winkler DG, 2003, EMBO J, V22, P6267, DOI 10.1093/emboj/cdg599
   Wright WS, 2007, DIABETES, V56, P295, DOI 10.2337/db06-1339
   Yang H, 2004, CIRC RES, V95, P1075, DOI 10.1161/01.RES.0000149564.49410.0d
   Yi FH, 2005, J BIOL CHEM, V280, P1457, DOI 10.1074/jbc.M411487200
NR 98
TC 278
Z9 318
U1 2
U2 44
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0888-8809
EI 1944-9917
J9 MOL ENDOCRINOL
JI Mol. Endocrinol.
PD NOV
PY 2007
VL 21
IS 11
BP 2605
EP 2614
DI 10.1210/me.2007-0259
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 224JV
UT WOS:000250444200001
PM 17622581
OA Bronze
DA 2025-06-11
ER

PT J
AU Wu, KLH
   Chao, YM
   Tsay, SJ
   Chen, CH
   Chan, SHH
   Dovinova, I
   Chan, JYH
AF Wu, Kay L. H.
   Chao, Yung-Mei
   Tsay, Shiow-Jen
   Chen, Chen Hsiu
   Chan, Samuel H. H.
   Dovinova, Ima
   Chan, Julie Y. H.
TI Role of Nitric Oxide Synthase Uncoupling at Rostral Ventrolateral
   Medulla in Redox-Sensitive Hypertension Associated With Metabolic
   Syndrome
SO HYPERTENSION
LA English
DT Article
DE hypertension; metabolic cardiovascular syndrome; nitric oxide; reactive
   oxygen species; sympathetic nervous system
ID SYMPATHETIC-NERVE ACTIVITY; OXIDATIVE STRESS; AUTONOMIC FUNCTION;
   PROTEIN INHIBITOR; ARCUATE NUCLEUS; UP-REGULATION; ENDOTHELIAL FUNCTION;
   INSULIN-RESISTANCE; ARTERIAL-PRESSURE; NO SYNTHASE
AB Metabolic syndrome (MetS), which is rapidly becoming prevalent worldwide, is long known to be associated with hypertension and recently with oxidative stress. Of note is that oxidative stress in the rostral ventrolateral medulla (RVLM), where sympathetic premotor neurons reside, contributes to sympathoexcitation and hypertension. This study sought to identify the source of tissue oxidative stress in RVLM and their roles in neural mechanism of hypertension associated with MetS. Adult normotensive rats subjected to a high-fructose diet for 8 weeks developed metabolic traits of MetS, alongside increases in sympathetic vasomotor activity and blood pressure. In RVLM of these MetS rats, the tissue level of reactive oxygen species was increased, nitric oxide (NO) was decreased, and mitochondrial electron transport capacity was reduced. Whereas the protein expression of neuronal NO synthase (nNOS) or protein inhibitor of nNOS was increased, the ratio of nNOS dimer/monomer was significantly decreased. Oral intake of pioglitazone or intracisternal infusion of tempol or coenzyme Q(10) significantly abrogated all those molecular events in high-fructose diet-fed rats and ameliorated sympathoexcitation and hypertension. Gene silencing of protein inhibitor of nNOS mRNA in RVLM using lentivirus carrying small hairpin RNA inhibited protein inhibitor of nNOS expression, increased the ratio of nNOS dimer/monomer, restored NO content, and alleviated oxidative stress in RVLM of high-fructose diet-fed rats, alongside significantly reduced sympathoexcitation and hypertension. These results suggest that redox-sensitive and protein inhibitor of nNOS-mediated nNOS uncoupling is engaged in a vicious cycle that sustains the production of reactive oxygen species in RVLM, resulting in sympathoexcitation and hypertension associated with MetS.
C1 [Wu, Kay L. H.; Chao, Yung-Mei; Chan, Samuel H. H.; Chan, Julie Y. H.] Kaohsiung Chang Gung Mem Hosp, Ctr Translat Res Biomed Sci, Kaohsiung 83301, Taiwan.
   [Tsay, Shiow-Jen] Natl Sun Yat Sen Univ, Inst Biol Sci, Kaohsiung 80424, Taiwan.
   [Chen, Chen Hsiu] Kaohsiung Vet Gen Hosp, Dept Anesthesiol, Kaohsiung, Taiwan.
   [Dovinova, Ima] Slovak Acad Sci, Inst Normal & Pathol Physiol, Bratislava, Slovakia.
C3 Chang Gung Memorial Hospital; National Sun Yat Sen University; Kaohsiung
   Veterans General Hospital; Slovak Academy of Sciences; Institute of
   Normal & Pathological Physiology, SAS
RP Chan, JYH (corresponding author), Kaohsiung Chang Gung Mem Hosp, Ctr Translat Res Biomed Sci, Kaohsiung 83301, Taiwan.
EM Ima.Dovinova@savba.sk; jchan@adm.cgmh.org.tw
RI Dovinova, Ima/F-2449-2018; Wu, Kay/ACD-1767-2022; Chan,
   Julie/X-5253-2019
OI DOVINOVA, IMA/0000-0001-9840-1950; Wu, Kay L.H./0000-0002-7297-6788
FU National Science Council [NSC100-2923-B-182A-001-MY3,
   NSC102-2321-B-182A-003]; Chang Gung Medical Foundation, Taiwan; Slovak
   Academy of Sciences, Slovakia [SAS-NSC JRP 2010/1]
FX This work was supported in part by research grants
   NSC100-2923-B-182A-001-MY3 and NSC102-2321-B-182A-003 (J.Y.H. Chan) from
   the National Science Council, CMRPG8C0051 (J.Y.H. Chan) from the Chang
   Gung Medical Foundation, Taiwan, and SAS-NSC JRP 2010/1 (I. Dovinova)
   from the Slovak Academy of Sciences, Slovakia.
CR Altuncu ME, 2012, CARDIOL J, V19, P501, DOI 10.5603/CJ.2012.0091
   Aroor Annayya R, 2013, Front Endocrinol (Lausanne), V4, P161, DOI 10.3389/fendo.2013.00161
   Bardgett ME, 2010, HYPERTENSION, V55, P284, DOI 10.1161/HYPERTENSIONAHA.109.146605
   Barnett AH, 2009, VASC HEALTH RISK MAN, V5, P141
   Cassaglia PA, 2011, J PHYSIOL-LONDON, V589, P1643, DOI 10.1113/jphysiol.2011.205575
   Chan SHH, 2006, FREE RADICAL BIO MED, V40, P2028, DOI 10.1016/j.freeradbiomed.2006.01.032
   Chan SHH, 2014, ANTIOXID REDOX SIGN, V20, P146, DOI 10.1089/ars.2013.5230
   Chan SHH, 2013, ANTIOXID REDOX SIGN, V19, P1074, DOI 10.1089/ars.2012.4585
   Chan SHH, 2010, CIRC RES, V107, P1127, DOI 10.1161/CIRCRESAHA.110.225573
   Chan SHH, 2010, HYPERTENSION, V55, P1444, DOI 10.1161/HYPERTENSIONAHA.109.149146
   Chan SHH, 2009, CIRC RES, V105, P886, DOI 10.1161/CIRCRESAHA.109.199018
   Chan SHH, 2009, HYPERTENSION, V53, P217, DOI 10.1161/HYPERTENSIONAHA.108.116905
   Chan SHH, 2005, CIRC RES, V97, P772, DOI 10.1161/01.RES.0000185804.79157.C0
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Crabtree MJ, 2011, NITRIC OXIDE-BIOL CH, V25, P81, DOI 10.1016/j.niox.2011.04.004
   Dampney RAL, 2011, J PHYSIOL-LONDON, V589, P2109, DOI 10.1113/jphysiol.2011.208579
   Davidson MB, 2005, NEW ENGL J MED, V352, P205
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Finkel J, 2012, NITRIC OXIDE-BIOL CH, V26, P81, DOI 10.1016/j.niox.2011.12.004
   Förstermann U, 2006, BIOL CHEM, V387, P1521, DOI 10.1515/BC.2006.190
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gao L, 2005, AM J PHYSIOL-HEART C, V288, pH2271, DOI 10.1152/ajpheart.00949.2004
   GHOSH DK, 1995, BIOCHEMISTRY-US, V34, P801, DOI 10.1021/bi00003a013
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Guyenet PG, 2006, NAT REV NEUROSCI, V7, P335, DOI 10.1038/nrn1902
   Hemmens B, 1998, FEBS LETT, V430, P397, DOI 10.1016/S0014-5793(98)00704-2
   Hirooka Y, 2011, HYPERTENS RES, V34, P407, DOI 10.1038/hr.2011.14
   Jaffrey SR, 1996, SCIENCE, V274, P774, DOI 10.1126/science.274.5288.774
   Katakam PVG, 2012, J CEREBR BLOOD F MET, V32, P792, DOI 10.1038/jcbfm.2011.181
   Kishi T, 2011, CLIN EXP HYPERTENS, V33, P240, DOI 10.3109/10641963.2011.583969
   Konno S, 2012, J HYPERTENS, V30, P1992, DOI 10.1097/HJH.0b013e328357fa98
   Krukoff TL, 1998, CLIN EXP PHARMACOL P, V25, P474, DOI 10.1111/j.1440-1681.1998.tb02238.x
   Kuo TBJ, 1997, AM J PHYSIOL-HEART C, V272, pH485, DOI 10.1152/ajpheart.1997.272.1.H485
   Leite LHR, 2012, J NEUROSCI METH, V211, P77, DOI 10.1016/j.jneumeth.2012.08.012
   Littarru GP, 2007, MOL BIOTECHNOL, V37, P31, DOI 10.1007/s12033-007-0052-y
   Liu DM, 2008, CIRC RES, V103, P186, DOI 10.1161/CIRCRESAHA.108.179408
   Mancia G, 2007, J HYPERTENS, V25, P909, DOI 10.1097/HJH.0b013e328048d004
   Yubero-Serrano EM, 2013, EXP MOL MED, V45, DOI 10.1038/emm.2013.53
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Moens AL, 2006, ARTERIOSCL THROM VAS, V26, P2439, DOI 10.1161/01.ATV.0000243924.00970.cb
   MUNTZEL MS, 1994, AM J PHYSIOL-REG I, V267, pR1350, DOI 10.1152/ajpregu.1994.267.5.R1350
   Nagae A, 2009, CIRCULATION, V119, P978, DOI 10.1161/CIRCULATIONAHA.108.824730
   Oron-Herman M, 2008, AM J HYPERTENS, V21, P1018, DOI 10.1038/ajh.2008.218
   Otani H, 2011, ANTIOXID REDOX SIGN, V15, P1911, DOI 10.1089/ars.2010.3739
   Palomo I, 2011, NITRIC OXIDE-BIOL CH, V24, P224, DOI 10.1016/j.niox.2011.03.002
   Paxinos G., RAT BRAIN STEREOTAXI
   Rochette L, 2013, PHARMACOL THERAPEUT, V140, P239, DOI 10.1016/j.pharmthera.2013.07.004
   Roncal CA, 2009, AM J NEPHROL, V30, P399, DOI 10.1159/000235731
   Sánchez A, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036027
   Santhanam AVR, 2012, J NEUROCHEM, V122, P1211, DOI 10.1111/j.1471-4159.2012.07872.x
   Sapru HN, 2013, AUTON NEUROSCI-BASIC, V175, P38, DOI 10.1016/j.autneu.2012.10.016
   Schnackenberg CG, 1998, HYPERTENSION, V32, P59, DOI 10.1161/01.HYP.32.1.59
   Sharabi Y, 2007, AM J HYPERTENS, V20, P206, DOI 10.1016/j.amjhyper.2006.08.002
   Sharma NM, 2013, AM J PHYSIOL-HEART C, V305, pH843, DOI 10.1152/ajpheart.00170.2013
   Smith MM, 2012, J PHYSIOL-LONDON, V590, P1787, DOI 10.1113/jphysiol.2011.221036
   Sohet FM, 2012, NUTR REV, V70, P631, DOI 10.1111/j.1753-4887.2012.00526.x
   Steinberger J, 2009, CIRCULATION, V119, P628, DOI 10.1161/CIRCULATIONAHA.108.191394
   Tentolouris N, 2008, NEUROMOL MED, V10, P169, DOI 10.1007/s12017-008-8022-5
   Thethi T, 2012, CURR HYPERTENS REP, V14, P160, DOI 10.1007/s11906-012-0245-z
   Thomas SR, 2008, ANTIOXID REDOX SIGN, V10, P1713, DOI 10.1089/ars.2008.2027
   Turrens JF, 2003, J PHYSIOL-LONDON, V552, P335, DOI 10.1113/jphysiol.2003.049478
   Waki H, 2006, EXP PHYSIOL, V91, P201, DOI 10.1113/expphysiol.2005.031716
   Wang SC, 2014, J AM SOC HYPERTENS, V8, P5, DOI 10.1016/j.jash.2013.07.010
   Wu KLH, 2009, J NEUROTRAUM, V26, P965, DOI 10.1089/neu.2008.0692
   Yeh TC, 2014, HYPERTENSION, V63, P535, DOI 10.1161/HYPERTENSIONAHA.113.02272
NR 65
TC 32
Z9 38
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD OCT
PY 2014
VL 64
IS 4
BP 815
EP +
DI 10.1161/HYPERTENSIONAHA.114.03777
PG 26
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AP3PB
UT WOS:000341988000021
PM 24958506
DA 2025-06-11
ER

PT J
AU Medford, HM
   Chatham, JC
   Marsh, SA
AF Medford, H. M.
   Chatham, J. C.
   Marsh, S. A.
TI Chronic ingestion of a Western diet increases
   O-linked-β-N-acetylglucosamine (O-GlcNAc) protein modification in the
   rat heart
SO LIFE SCIENCES
LA English
DT Article
DE Western diet; saturated fat; O-GlcNAc; cardiac metabolism
ID HIGH-FAT DIET; IMPROVES CONTRACTILE FUNCTION; METABOLIC SYNDROME;
   CARDIOMYOCYTE DYSFUNCTION; CARDIAC-HYPERTROPHY; OBESITY; GLCNACYLATION;
   ACTIVATION; CONTRIBUTES; PREVALENCE
AB Aims: Protein O-GlcNAcylation is both a nutrient sensing and cellular stress response that mediates signal transduction in the heart. Chronically elevated O-GlcNAc has been associated with the development of cardiac dysfunction at both the cellular and organ levels in obesity, insulin resistance and diabetes. Development of these pathologies is often attributed to diets high in saturated fat and sugar (a "Western" diet; WES) but a role for O-GlcNAc in diet-induced cardiac dysfunction has not been established. The aims of this study were to examine the effect of chronic consumption of WES on cardiac O-GlcNAcylation and investigate associations of O-GlcNAc with cardiac function and markers of cellular stress.
   Main methods: Young male rats received either a control diet (CON; n = 9) or WES (n = 8) diet for 52 weeks.
   Key findings: There was no evidence of cardiac dysfunction, advanced glycation endproduct (AGE) accumulation, pathological cardiac hypertrophy, calcium handling impairment, fibrosis or endoplasmic reticulum stress in WES hearts. However, cardiac O-GlcNAc protein, particularly in the higher molecular weight range, was significantly higher in WES hearts compared to CON (P<0.05). Protein levels of the enzymes that regulate O-GlcNAc attachment were not different between groups; thus, the increased O-GlcNAcylation in WES hearts appears to be due to increased nutrient availability rather than enzymatic regulation of cellular stress.
   Significance: These data suggest that diets high in saturated fat and sugar may contribute to the adverse effects of metabolic syndrome and diabetes by an O-GlcNAc-mediated process and that this may occur in the absence of overt cellular stress. (c) 2012 Elsevier Inc. All rights reserved.
C1 [Marsh, S. A.] Washington State Univ, Coll Pharm, Program Nutr & Exercise Physiol, Spokane, WA 99210 USA.
   [Medford, H. M.] Washington State Univ, Coll Pharm, Grad Program Nutr & Exercise Physiol, Spokane, WA 99210 USA.
   [Chatham, J. C.] Univ Alabama Birmingham, Dept Pathol, Div Mol & Cellular Pathol, Birmingham, AL USA.
C3 Washington State University; Washington State University; University of
   Alabama System; University of Alabama Birmingham
RP Marsh, SA (corresponding author), Washington State Univ, Coll Pharm, Program Nutr & Exercise Physiol, POB 1495, Spokane, WA 99210 USA.
EM samarsh@wsu.edu
RI Marsh, Sue/J-3711-2014
OI Chatham, John/0000-0001-7180-9948
FU National Institute of Health [HL-104549, HL-77100, HL-67464, HL-101192];
   WSU College of Pharmacy
FX This work was supported by National Institute of Health grants
   (HL-104549 to SAM and HL-77100, HL-67464, HL-101192 to JCC) and the WSU
   College of Pharmacy (SAM). We are grateful for the technical support
   provided by Charlye A. Brocks, W. Eddie Bradley and Dr. Karen Porter.
CR Akki A, 2009, CARDIOVASC RES, V81, P610, DOI 10.1093/cvr/cvn316
   [Anonymous], 2008, NAT DIAB FACT SHEET
   Berthiaume JM, 2010, AM J PHYSIOL-HEART C, V299, pH410, DOI 10.1152/ajpheart.00270.2010
   Boglarka L, 2010, AM J PHYSIOL-HEART C, V299, pH1715, DOI 10.1152/ajpheart.00337.2010
   Burgmaier M, 2010, OBESITY, V18, P1895, DOI 10.1038/oby.2009.500
   CAPASSO JM, 1983, AM J PHYSIOL, V245, pH72, DOI 10.1152/ajpheart.1983.245.1.H72
   Davidoff AJ, 2004, AM J PHYSIOL-ENDOC M, V286, pE718, DOI 10.1152/ajpendo.00358.2003
   Demigné C, 2006, EUR J NUTR, V45, P298, DOI 10.1007/s00394-006-0599-6
   Esmaillzadeh A, 2007, AM J CLIN NUTR, V85, P910, DOI 10.1093/ajcn/85.3.910
   Fülöp N, 2008, BIOGERONTOLOGY, V9, P139, DOI 10.1007/s10522-007-9123-5
   Fülöp N, 2007, AM J PHYSIOL-CELL PH, V292, pC1370, DOI 10.1152/ajpcell.00422.2006
   GRIFFITH LS, 1995, BIOCHEM BIOPH RES CO, V213, P424, DOI 10.1006/bbrc.1995.2149
   Hanover JA, 2010, CHEM BIOL, V17, P1272, DOI 10.1016/j.chembiol.2010.12.001
   Hartvigsen K, 2007, ARTERIOSCL THROM VAS, V27, P878, DOI 10.1161/01.ATV.0000258790.35810.02
   Hu Y, 2005, CIRC RES, V96, P1006, DOI 10.1161/01.RES.0000165478.06813.58
   Kenchaiah S, 2002, NEW ENGL J MED, V347, P305, DOI 10.1056/NEJMoa020245
   Laczy B, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0018417
   Li SY, 2005, DIABETES OBES METAB, V7, P448, DOI 10.1111/j.1463-1326.2004.00387.x
   Lima VV, 2011, CARDIOVASC RES, V89, P614, DOI 10.1093/cvr/cvq338
   Lima VV, 2009, HYPERTENSION, V53, P166, DOI 10.1161/HYPERTENSIONAHA.108.116798
   Lutsey PL, 2008, CIRCULATION, V117, P754, DOI 10.1161/CIRCULATIONAHA.107.716159
   Marsh SA, 2011, AMINO ACIDS, V40, P819, DOI 10.1007/s00726-010-0699-8
   Marsh SA, 2009, AM J PHYSIOL-HEART C, V296, pH282, DOI 10.1152/ajpheart.00421.2008
   Ogden CL, 2006, JAMA-J AM MED ASSOC, V295, P1549, DOI 10.1001/jama.295.13.1549
   Okere IC, 2005, CLIN EXP PHARMACOL P, V32, P825, DOI 10.1111/j.1440-1681.2005.04272.x
   Peterson LR, 2004, J AM COLL CARDIOL, V43, P1399, DOI 10.1016/j.jacc.2003.10.062
   Ramirez-Correa GA, 2008, CIRC RES, V103, P1354, DOI 10.1161/CIRCRESAHA.108.184978
   Taylor RP, 2008, J BIOL CHEM, V283, P6050, DOI 10.1074/jbc.M707328200
   Wilson CR, 2007, BIOCHEM J, V406, P457, DOI 10.1042/BJ20070392
   Wold LE, 2005, J MOL CELL CARDIOL, V39, P297, DOI 10.1016/j.yjmcc.2005.03.014
   Yokoe S, 2010, GLYCOBIOLOGY, V20, P1217, DOI 10.1093/glycob/cwq071
   Zachara NE, 2004, J BIOL CHEM, V279, P30133, DOI 10.1074/jbc.M403773200
   Zhou YT, 2000, P NATL ACAD SCI USA, V97, P1784, DOI 10.1073/pnas.97.4.1784
NR 33
TC 38
Z9 43
U1 0
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JUN 14
PY 2012
VL 90
IS 23-24
BP 883
EP 888
DI 10.1016/j.lfs.2012.04.030
PG 6
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 962LO
UT WOS:000305546800001
PM 22575823
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Colldén, G
   Tschöp, MH
   Müller, TD
AF Collden, Gustav
   Tschoep, Matthias H.
   Mueller, Timo D.
TI Therapeutic Potential of Targeting the Ghrelin Pathway
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE ghrelin; therapy; pathology; inflammation; anorexia
ID DES-ACYL GHRELIN; ACUTE LUNG INJURY; HORMONE SECRETAGOGUE RECEPTOR;
   DIET-INDUCED OBESITY; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; INDUCED
   PULMONARY-HYPERTENSION; ANOREXIA-CACHEXIA SYNDROME; SPINAL-CORD
   MOTONEURONS; VENTRAL TEGMENTAL AREA; STIMULATES FOOD-INTAKE
AB Ghrelin was discovered in 1999 as the endogenous ligand of the growth-hormone secretagogue receptor 1a (GHSR1a). Since then, ghrelin has been found to exert a plethora of physiological effects that go far beyond its initial characterization as a growth hormone (GH) secretagogue. Among the numerous well-established effects of ghrelin are the stimulation of appetite and lipid accumulation, the modulation of immunity and inflammation, the stimulation of gastric motility, the improvement of cardiac performance, the modulation of stress, anxiety, taste sensation and reward-seeking behavior, as well as the regulation of glucose metabolism and thermogenesis. Due to a variety of beneficial effects on systems' metabolism, pharmacological targeting of the endogenous ghrelin system is widely considered a valuable approach to treat metabolic complications, such as chronic inflammation, gastroparesis or cancer-associated anorexia and cachexia. The aim of this review is to discuss and highlight the broad pharmacological potential of ghrelin pathway modulation for the treatment of anorexia, cachexia, sarcopenia, cardiopathy, neurodegenerative disorders, renal and pulmonary disease, gastrointestinal (GI) disorders, inflammatory disorders and metabolic syndrome.
C1 [Collden, Gustav; Tschoep, Matthias H.; Mueller, Timo D.] German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Munchen, Inst Diabet & Obes, D-85764 Neuherberg, Germany.
   [Collden, Gustav; Tschoep, Matthias H.; Mueller, Timo D.] German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Munchen, Helmholtz Diabet Ctr, D-85764 Neuherberg, Germany.
   [Tschoep, Matthias H.] Tech Univ Munich, Div Metab Dis, Dept Med, D-80333 Munich, Germany.
   [Mueller, Timo D.] Inst Diabet & Obes, Business Campus Garching Hochbruck,Parkring 13, D-85748 Garching, Germany.
C3 Helmholtz Association; Helmholtz-Center Munich - German Research Center
   for Environmental Health; Helmholtz Association; Helmholtz-Center Munich
   - German Research Center for Environmental Health; Technical University
   of Munich
RP Müller, TD (corresponding author), German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Munchen, Inst Diabet & Obes, D-85764 Neuherberg, Germany.; Müller, TD (corresponding author), German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Munchen, Helmholtz Diabet Ctr, D-85764 Neuherberg, Germany.; Müller, TD (corresponding author), Inst Diabet & Obes, Business Campus Garching Hochbruck,Parkring 13, D-85748 Garching, Germany.
EM gustav.collden@helmholtz-muenchen.de;
   matthias.tschoep@helmholtz-muenchen.de;
   timo.mueller@helmholtz-muenchen.de
RI Müller, Timo/AAZ-4445-2020; Tschoep, Matthias/I-5443-2014
OI Muller, Timo/0000-0002-0624-9339
FU Alexander von Humboldt Foundation; Helmholtz Alliance Imaging and Curing
   Environmental Metabolic Diseases (ICEMED); Helmholtz Initiative on
   Personalized Medicine iMed by the Helmholtz Association; Helmholtz
   cross-program topic "Metabolic Dysfunction"; German Research Foundation
   [DFG-TS226/1-1, DFG-TS226/3-1, SFB1123]; European Research Council ERC
   AdG HypoFlam [695054]
FX This work was supported in part by funding from the Alexander von
   Humboldt Foundation, the Helmholtz Alliance Imaging and Curing
   Environmental Metabolic Diseases (ICEMED) and the Helmholtz Initiative
   on Personalized Medicine iMed by the Helmholtz Association and the
   Helmholtz cross-program topic "Metabolic Dysfunction". This work was
   further supported by grants from the German Research Foundation
   DFG-TS226/1-1, DFG-TS226/3-1, SFB1123, and the European Research Council
   ERC AdG HypoFlam No. 695054. The figures were made by using material
   from Servier Medical Art (Servier) under consideration of a Creative
   Commons Attribution 3.0 Unported License, as well as material from
   Wikimedia Commons. Timo D. Muller and Gustav Collden have no conflicts
   of interest, financial or otherwise. Matthias H. Tschop is a scientific
   advisor for Novo Nordisk, Bionorica SE and Erx Biotech.
CR Abizaid A, 2006, J CLIN INVEST, V116, P3229, DOI 10.1172/JCI29867
   Akamizu T, 2006, J ENDOCRINOL, V188, P333, DOI 10.1677/joe.1.06442
   Akamizu T, 2004, EUR J ENDOCRINOL, V150, P447, DOI 10.1530/eje.0.1500447
   Akamizu T, 2008, EUR J ENDOCRINOL, V158, P491, DOI 10.1530/EJE-07-0768
   Alamri BN, 2016, HORM MOL BIOL CLIN I, V26, P3, DOI 10.1515/hmbci-2016-0018
   Alvarez-Crespo M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046321
   Andrade S, 2013, CURR PHARM DESIGN, V19, P6551, DOI 10.2174/13816128113199990506
   Andrews ZB, 2008, NATURE, V454, P846, DOI 10.1038/nature07181
   Andrews ZB, 2009, J NEUROSCI, V29, P14057, DOI 10.1523/JNEUROSCI.3890-09.2009
   Arai M, 2012, HEPATO-GASTROENTEROL, V59, P62, DOI 10.5754/hge11246
   Asakawa A, 2005, GUT, V54, P18, DOI 10.1136/gut.2004.038737
   Asakawa A, 2003, GUT, V52, P947, DOI 10.1136/gut.52.7.947
   Ashby DR, 2009, KIDNEY INT, V76, P199, DOI 10.1038/ki.2009.114
   Ayala ER, 2004, NEPHROL DIAL TRANSPL, V19, P421, DOI 10.1093/ndt/gfg559
   Balasubramaniam A, 2009, AM J PHYSIOL-REG I, V296, pR893, DOI 10.1152/ajpregu.00015.2008
   Baldanzi G, 2002, J CELL BIOL, V159, P1029, DOI 10.1083/jcb.200207165
   Barazzoni R, 2014, OBESITY, V22, P170, DOI 10.1002/oby.20454
   Barazzoni R, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026224
   Barnett BP, 2010, SCIENCE, V330, P1689, DOI 10.1126/science.1196154
   Bavil FM, 2015, ADV PHARM BULL, V5, P315, DOI 10.15171/apb.2015.044
   Bayliss JA, 2016, J NEUROSCI, V36, P3049, DOI 10.1523/JNEUROSCI.4373-15.2016
   Beauloye V, 2016, ORPHANET J RARE DIS, V11, DOI 10.1186/s13023-016-0440-0
   Beiras-Fernandez A, 2010, PEPTIDES, V31, P2222, DOI 10.1016/j.peptides.2010.08.019
   Bennett KA, 2009, MOL PHARMACOL, V76, P802, DOI 10.1124/mol.109.056101
   Berilgen MS, 2005, NEUROENDOCRINOL LETT, V26, P819
   Beynon AL, 2013, J NEUROINFLAMM, V10, DOI 10.1186/1742-2094-10-40
   BLAKE AD, 1991, J ENDOCRINOL, V129, P11, DOI 10.1677/joe.0.1290011
   Borner T, 2016, AM J PHYSIOL-REG I, V311, pR89, DOI 10.1152/ajpregu.00044.2016
   BOWERS CY, 1990, J CLIN ENDOCR METAB, V70, P975, DOI 10.1210/jcem-70-4-975
   BOWERS CY, 1980, ENDOCRINOLOGY, V106, P663, DOI 10.1210/endo-106-3-663
   Brial F, 2015, DIABETES, V64, P3314, DOI 10.2337/db15-0124
   Briggs DI, 2010, ENDOCRINOLOGY, V151, P4745, DOI 10.1210/en.2010-0556
   Broglio F, 2004, J CLIN ENDOCR METAB, V89, P3062, DOI 10.1210/jc.2003-031964
   Broglio F, 2001, J CLIN ENDOCR METAB, V86, P5083, DOI 10.1210/jc.86.10.5083
   Bulgarelli I, 2009, J NEUROSCI RES, V87, P2718, DOI 10.1002/jnr.22088
   Cappellari GG, 2016, DIABETES, V65, P874, DOI 10.2337/db15-1019
   Carlini VP, 2010, PHYSIOL BEHAV, V101, P117, DOI 10.1016/j.physbeh.2010.04.026
   Carlini VP, 2002, BIOCHEM BIOPH RES CO, V299, P739, DOI 10.1016/S0006-291X(02)02740-7
   Cassoni P, 2006, J ENDOCRINOL INVEST, V29, P781, DOI 10.1007/BF03347371
   Chan CB, 2004, FEBS LETT, V577, P147, DOI 10.1016/j.febslet.2004.08.088
   Chance WT, 2008, NUTR CANCER, V60, P75, DOI 10.1080/01635580701753016
   Chang L, 2004, J CARDIOVASC PHARM, V43, P165, DOI 10.1097/00005344-200402000-00001
   Chang L, 2003, EUR J PHARMACOL, V473, P171, DOI 10.1016/S0014-2999(03)01972-1
   Chang L, 2003, ACTA PHARMACOL SIN, V24, P45
   Checchi S, 2007, J CLIN ENDOCR METAB, V92, P4346, DOI 10.1210/jc.2007-0988
   Chen HY, 2004, ENDOCRINOLOGY, V145, P2607, DOI 10.1210/en.2003-1596
   Chen JA, 2015, J CACHEXIA SARCOPENI, V6, P132, DOI 10.1002/jcsm.12023
   Chen J, 2008, MED SCI MONITOR, V14, pBR141
   Chen LA, 2011, EUR J NEUROSCI, V33, P266, DOI 10.1111/j.1460-9568.2010.07491.x
   Chen XD, 2013, METABOLISM, V62, P743, DOI 10.1016/j.metabol.2012.09.014
   Chen Y, 2010, BIOL PHARM BULL, V33, P1165, DOI 10.1248/bpb.33.1165
   CHENG K, 1991, ENDOCRINOLOGY, V129, P3337
   Cheyuo C, 2011, SHOCK, V35, P258, DOI 10.1097/SHK.0b013e3181f48a37
   Choi HP, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0066605
   Chung H, 2007, ENDOCRINOLOGY, V148, P148, DOI 10.1210/en.2006-0991
   Clemmensen C, 2015, EMBO MOL MED, V7, P288, DOI 10.15252/emmm.201404508
   Cohen RI, 2008, J CYST FIBROS, V7, P398, DOI 10.1016/j.jcf.2008.02.002
   Cowley MA, 2003, NEURON, V37, P649, DOI 10.1016/S0896-6273(03)00063-1
   Cummings DE, 2002, NAT MED, V8, P643, DOI 10.1038/nm0702-643
   Cummings DE, 2001, DIABETES, V50, P1714, DOI 10.2337/diabetes.50.8.1714
   Czell D, 2016, AMYOTROPH LAT SCL FR, V17, P295, DOI 10.3109/21678421.2015.1113299
   De Vriese C, 2004, ENDOCRINOLOGY, V145, P4997, DOI 10.1210/en.2004-0569
   De Waele K, 2008, EUR J ENDOCRINOL, V159, P381, DOI 10.1530/EJE-08-0462
   DeBoer MD, 2008, ENDOCRINOLOGY, V149, P827, DOI 10.1210/en.2007-1046
   DeBoer MD, 2007, ENDOCRINOLOGY, V148, P3004, DOI 10.1210/en.2007-0016
   Delhanty PJ, 2013, ENDOCR DEV, V25, P112, DOI 10.1159/000346059
   DelPparigi A, 2002, J CLIN ENDOCR METAB, V87, P5461, DOI 10.1210/jc.2002-020871
   Deveci Y, 2010, TUBERK TORAK, V58, P162
   Dezaki K, 2006, DIABETES, V55, P3486, DOI 10.2337/db06-0878
   Dhurandhar EJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0060437
   DICKSON SL, 1993, NEUROSCIENCE, V53, P303, DOI 10.1016/0306-4522(93)90197-N
   Dietrich MO, 2010, J NEUROSCI, V30, P11815, DOI 10.1523/JNEUROSCI.2234-10.2010
   Dixit VD, 2004, J CLIN INVEST, V114, P57, DOI 10.1172/JCI200421134
   dos Santos VV, 2013, CURR PHARM DESIGN, V19, P6773
   Edholm T, 2004, REGUL PEPTIDES, V121, P25, DOI 10.1016/j.regpep.2004.04.001
   Eftekhari E, 2013, IRAN J NEUROL, V12, P60
   Elsayed NM, 2009, SAUDI MED J, V30, P109
   Ersahin M, 2010, J NEUROTRAUM, V27, P1143, DOI 10.1089/neu.2009.1210
   Esler WP, 2007, ENDOCRINOLOGY, V148, P5175, DOI 10.1210/en.2007-0239
   Faulconbridge LF, 2003, DIABETES, V52, P2260, DOI 10.2337/diabetes.52.9.2260
   Filigheddu N, 2007, MOL BIOL CELL, V18, P986, DOI 10.1091/mbc.E06-05-0402
   Finan B, 2016, CELL, V167, P843, DOI 10.1016/j.cell.2016.09.014
   Finan B, 2015, NAT MED, V21, P27, DOI 10.1038/nm.3761
   Finan B, 2012, NAT MED, V18, P1847, DOI 10.1038/nm.3009
   Fischer Katrin, 2014, Front Nutr, V1, P31, DOI 10.3389/fnut.2014.00031
   Freeman JN, 2013, PEPTIDES, V42, P35, DOI 10.1016/j.peptides.2013.02.003
   Fujino K, 2003, J PHYSIOL-LONDON, V550, P227, DOI 10.1113/jphysiol.2003.040600
   Fujitsuka N, 2016, MOL PSYCHIATR, V21, P1613, DOI 10.1038/mp.2015.220
   Gagnon J, 2015, GENE THER, V22, P750, DOI 10.1038/gt.2015.38
   Gahete MD, 2011, PEPTIDES, V32, P2225, DOI 10.1016/j.peptides.2011.09.019
   Gahete MD, 2010, MOL CELL ENDOCRINOL, V317, P154, DOI 10.1016/j.mce.2009.12.023
   Garcia JM, 2015, LANCET ONCOL, V16, P108, DOI 10.1016/S1470-2045(14)71154-4
   Gauna C, 2004, J CLIN ENDOCR METAB, V89, P5035, DOI 10.1210/jc.2004-0363
   Gauna C, 2005, J CLIN ENDOCR METAB, V90, P1055, DOI 10.1210/jc.2004-1069
   Gnanapavan S, 2002, J CLIN ENDOCR METAB, V87, P2988, DOI 10.1210/jc.87.6.2988
   Gonzalez-Rey E, 2006, GASTROENTEROLOGY, V130, P1707, DOI 10.1053/j.gastro.2006.01.041
   Govoni N, 2005, J ENDOCRINOL, V186, P505, DOI 10.1677/joe.1.06262
   Granado M, 2005, AM J PHYSIOL-ENDOC M, V288, pE486, DOI 10.1152/ajpendo.00196.2004
   Grey CL, 2009, GEN COMP ENDOCR, V160, P148, DOI 10.1016/j.ygcen.2008.11.006
   Guan XM, 1997, MOL BRAIN RES, V48, P23, DOI 10.1016/S0169-328X(97)00071-5
   Gutierrez JA, 2008, P NATL ACAD SCI USA, V105, P6320, DOI 10.1073/pnas.0800708105
   Guven B, 2013, KAOHSIUNG J MED SCI, V29, P69, DOI 10.1016/j.kjms.2012.08.011
   Hanada T, 2003, BIOCHEM BIOPH RES CO, V301, P275, DOI 10.1016/S0006-291X(02)03028-0
   Haqq AM, 2003, J CLIN ENDOCR METAB, V88, P3573, DOI 10.1210/jc.2003-030205
   Haruta I, 2015, J CACHEXIA SARCOPENI, V6, P237, DOI 10.1002/jcsm.12028
   Henriques-Coelho T, 2004, AM J PHYSIOL-HEART C, V287, pH2885, DOI 10.1152/ajpheart.01122.2003
   Holm T, 2013, INTERACT J MED RES, V2, P78, DOI 10.2196/ijmr.2463
   Hotta M, 2009, ENDOCR J, V56, P1119, DOI 10.1507/endocrj.K09E-168
   Howard AD, 1996, SCIENCE, V273, P974, DOI 10.1126/science.273.5277.974
   Huang CX, 2009, PEPTIDES, V30, P2286, DOI 10.1016/j.peptides.2009.09.004
   Imazu Y, 2011, EUR J PHARMACOL, V672, P153, DOI 10.1016/j.ejphar.2011.09.183
   Inhoff T, 2008, PEPTIDES, V29, P2159, DOI 10.1016/j.peptides.2008.09.014
   Isomoto H, 2004, AM J MED, V117, P429, DOI 10.1016/j.amjmed.2004.01.030
   Itoh T, 2004, AM J RESP CRIT CARE, V170, P879, DOI 10.1164/rccm.200310-1404OC
   Jarkovská Z, 2005, PHYSIOL RES, V54, P403, DOI 10.33549/physiolres.930538
   Jiang H, 2008, EXP NEUROL, V212, P532, DOI 10.1016/j.expneurol.2008.05.006
   Kamiide Y, 2015, EUR J PHARMACOL, V755, P88, DOI 10.1016/j.ejphar.2015.02.049
   Kang S, 2015, PEPTIDES, V71, P84, DOI 10.1016/j.peptides.2015.07.005
   Kanoski SE, 2013, BIOL PSYCHIAT, V73, P915, DOI 10.1016/j.biopsych.2012.07.002
   Kanumakala S, 2005, J CLIN ENDOCR METAB, V90, P2691, DOI 10.1210/jc.2004-2175
   Karasawa H, 2014, NEUROGASTROENT MOTIL, V26, P1771, DOI 10.1111/nmo.12459
   Kasimay Ö, 2006, HEPATOL RES, V36, P11, DOI 10.1016/j.hepres.2006.06.009
   Kent BA, 2015, PSYCHONEUROENDOCRINO, V51, P431, DOI 10.1016/j.psyneuen.2014.10.015
   Khatib MN, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0126697
   Khowailed A, 2015, CLIN EXP NEPHROL, V19, P419, DOI 10.1007/s10157-014-1006-x
   Kidd P M, 2001, Altern Med Rev, V6, P540
   Kim JH, 2010, CLIN NUTR, V29, P512, DOI 10.1016/j.clnu.2010.01.008
   Kirchner H, 2009, NAT MED, V15, P741, DOI 10.1038/nm.1997
   Kodama T, 2008, PULM PHARMACOL THER, V21, P774, DOI 10.1016/j.pupt.2008.05.001
   Kohno D, 2003, DIABETES, V52, P948, DOI 10.2337/diabetes.52.4.948
   Kohno D, 2008, BIOCHEM BIOPH RES CO, V366, P388, DOI 10.1016/j.bbrc.2007.11.166
   Kojima M, 1999, NATURE, V402, P656, DOI 10.1038/45230
   Konturek PC, 2009, J PHYSIOL PHARMACOL, V60, P41
   Kouno T, 2016, J ENDOCRINOL, V228, P115, DOI 10.1530/JOE-15-0330
   Kunath N, 2016, NEUROIMAGE, V142, P455, DOI 10.1016/j.neuroimage.2016.07.016
   Kunath N, 2015, SCI REP-UK, V5, DOI 10.1038/srep11452
   Kuppens RJ, 2015, ENDOCRINE, V50, P633, DOI 10.1007/s12020-015-0614-x
   Kweh FA, 2015, AM J MED GENET A, V167, P69, DOI 10.1002/ajmg.a.36810
   Kyoraku I, 2009, BIOCHEM BIOPH RES CO, V389, P405, DOI 10.1016/j.bbrc.2009.08.171
   Lacerda-Miranda G, 2012, PEPTIDES, V35, P65, DOI 10.1016/j.peptides.2012.02.025
   Lage R, 2010, FASEB J, V24, P2670, DOI 10.1096/fj.09-150672
   Lee JY, 2010, ENDOCRINOLOGY, V151, P3815, DOI 10.1210/en.2009-1416
   Lee JH, 2016, DIABETES, V65, P2169, DOI 10.2337/db15-1587
   Lee KJ, 2009, DIGESTION, V80, P58, DOI 10.1159/000215389
   Lee S, 2012, KOREAN J PHYSIOL PHA, V16, P43, DOI 10.4196/kjpp.2012.16.1.43
   Lembo A, 2016, GASTROENTEROLOGY, V151, P87, DOI 10.1053/j.gastro.2016.03.038
   Li B, 2015, ENDOCRINOLOGY, V156, P203, DOI 10.1210/en.2014-1539
   Li GA, 2010, TOHOKU J EXP MED, V222, P7, DOI 10.1620/tjem.222.7
   Li WG, 2004, CIRCULATION, V109, P2221, DOI 10.1161/01.CIR.0000127956.43874.F2
   Li Y, 2013, ENDOCRINE, V43, P376, DOI 10.1007/s12020-012-9761-5
   Li ZF, 2013, CHINESE MED J-PEKING, V126, P3936, DOI 10.3760/cma.j.issn.0366-6999.20123353
   Lim E, 2011, EXP NEUROL, V230, P114, DOI 10.1016/j.expneurol.2011.04.003
   Lin LG, 2011, AGING CELL, V10, P996, DOI 10.1111/j.1474-9726.2011.00740.x
   Liu JH, 2008, J CLIN ENDOCR METAB, V93, P1980, DOI 10.1210/jc.2007-2235
   Liu YL, 2006, CANCER CHEMOTH PHARM, V58, P326, DOI 10.1007/s00280-005-0179-0
   Liu YJ, 2006, CHINESE J PHYSIOL, V49, P244
   Liu Yao, 2014, Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, V32, P190
   López M, 2008, CELL METAB, V7, P389, DOI 10.1016/j.cmet.2008.03.006
   Lu SC, 2009, MOL PHARMACOL, V75, P901, DOI 10.1124/mol.108.052852
   Luo FM, 2005, NUTRITION, V21, P793, DOI 10.1016/j.nut.2004.11.015
   Luquet S, 2005, SCIENCE, V310, P683, DOI 10.1126/science.1115524
   Luquet S, 2007, PEPTIDES, V28, P214, DOI 10.1016/j.peptides.2006.08.036
   Machado MC, 2007, J ENDOCRINOL INVEST, V30, P334, DOI 10.1007/BF03346301
   Maletínská L, 2011, MOL CELL ENDOCRINOL, V343, P55, DOI 10.1016/j.mce.2011.06.006
   Marrinan S, 2014, MOVEMENT DISORD, V29, P23, DOI 10.1002/mds.25708
   Martins L, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046923
   Mary S, 2012, P NATL ACAD SCI USA, V109, P8304, DOI 10.1073/pnas.1119881109
   Masuda Y, 2000, BIOCHEM BIOPH RES CO, V276, P905, DOI 10.1006/bbrc.2000.3568
   Matsumoto N, 2015, LUNG, V193, P239, DOI 10.1007/s00408-015-9685-y
   Matsuo T., 2014, F1000RESEARCH, V5, P223
   McFarlane MR, 2014, CELL METAB, V20, P54, DOI 10.1016/j.cmet.2014.04.007
   Miao YY, 2007, BIOCHEM BIOPH RES CO, V359, P795, DOI 10.1016/j.bbrc.2007.05.192
   Miki K., 2015, CLIN RESPIR  J
   Miki K, 2015, J PHYSIOL SCI, V65, P277, DOI 10.1007/s12576-015-0366-7
   Miki K, 2013, BMC PULM MED, V13, DOI 10.1186/1471-2466-13-37
   Miki K, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035708
   Miljic D, 2006, J CLIN ENDOCR METAB, V91, P1491, DOI 10.1210/jc.2005-2304
   Miyasaki Y, 2013, PLOS ONE, V8, DOI [10.1371/journal.pone.0061594, 10.1371/journal.pone.0064777]
   MOMANY FA, 1981, ENDOCRINOLOGY, V108, P31, DOI 10.1210/endo-108-1-31
   Moon M, 2014, J ALZHEIMERS DIS, V41, P233, DOI 10.3233/JAD-132417
   Moon M, 2011, J ALZHEIMERS DIS, V23, P147, DOI 10.3233/JAD-2010-101263
   Moon M, 2009, NEUROTOX RES, V15, P332, DOI 10.1007/s12640-009-9037-x
   Mora M, 2014, AGING CLIN EXP RES, V26, P161, DOI 10.1007/s40520-014-0203-5
   Müller TD, 2015, MOL METAB, V4, P437, DOI 10.1016/j.molmet.2015.03.005
   Müller TD, 2010, J CACHEXIA SARCOPENI, V1, P159, DOI 10.1007/s13539-010-0012-4
   Nagaya N, 2005, CHEST, V128, P1187, DOI 10.1378/chest.128.3.1187
   Nagaya N, 2004, CIRCULATION, V110, P3674, DOI 10.1161/01.CIR.0000149746.62908.BB
   Nagaya N, 2001, CIRCULATION, V104, P2034, DOI 10.1161/hc4201.097836
   Nagaya N, 2001, CIRCULATION, V104, P1430, DOI 10.1161/hc3601.095575
   Nahata M, 2012, AM J PHYSIOL-GASTR L, V303, pG42, DOI 10.1152/ajpgi.00462.2011
   Nakai Y, 2003, EUR J ENDOCRINOL, V149, pR1, DOI 10.1530/eje.0.149R001
   Naleid AM, 2005, PEPTIDES, V26, P2274, DOI 10.1016/j.peptides.2005.04.025
   Nass R, 2008, ANN INTERN MED, V149, P601, DOI 10.7326/0003-4819-149-9-200811040-00003
   Nass R, 2014, J CLIN ENDOCR METAB, V99, P602, DOI 10.1210/jc.2013-3158
   Natalucci G, 2005, EUR J ENDOCRINOL, V152, P845, DOI 10.1530/eje.1.01919
   Naznin F, 2015, J ENDOCRINOL, V226, P81, DOI 10.1530/JOE-15-0139
   Neary NM, 2006, GUT, V55, P135
   Neary NM, 2004, J CLIN ENDOCR METAB, V89, P2832, DOI 10.1210/jc.2003-031768
   Ngo ST, 2015, J NEUROL SCI, V357, P22, DOI 10.1016/j.jns.2015.06.053
   Northrup R, 2013, SUPPORT CARE CANCER, V21, P2409, DOI 10.1007/s00520-013-1800-0
   Nüsken KD, 2004, NEPHROL DIAL TRANSPL, V19, P2156, DOI 10.1093/ndt/gfh310
   Otto B, 2001, Eur J Endocrinol, V145, P669
   Özcan B, 2014, EUR J ENDOCRINOL, V170, P799, DOI 10.1530/EJE-13-0347
   Peng Min, 2007, Zhonghua Jiehe He Huxi Zazhi, V30, P182
   Peng ZY, 2012, INT IMMUNOPHARMACOL, V13, P440, DOI 10.1016/j.intimp.2012.04.006
   Perboni S, 2008, WORLD J GASTROENTERO, V14, P6303, DOI 10.3748/wjg.14.6303
   Perreault M, 2004, INT J OBESITY, V28, P879, DOI 10.1038/sj.ijo.0802640
   Pfluger PT, 2008, AM J PHYSIOL-GASTR L, V294, pG610, DOI 10.1152/ajpgi.00321.2007
   Philips T, 2011, LANCET NEUROL, V10, P253, DOI 10.1016/S1474-4422(11)70015-1
   Pietra C, 2014, J CACHEXIA SARCOPENI, V5, P329, DOI 10.1007/s13539-014-0159-5
   Proto C, 2006, GYNECOL ENDOCRINOL, V22, P213, DOI 10.1080/09513590500519385
   Qiu WC, 2008, CHINESE MED J-PEKING, V121, P1183, DOI 10.1097/00029330-200807010-00007
   Qiu WC, 2008, WORLD J GASTROENTERO, V14, P2572, DOI 10.3748/wjg.14.2572
   Qiu WC, 2008, WORLD J GASTROENTERO, V14, P1419, DOI 10.3748/wjg.14.1419
   Rak-Mardyla A, 2010, J PHYSIOL PHARMACOL, V61, P451
   Rey LK, 2011, MOL CELL PROBE, V25, P255, DOI 10.1016/j.mcp.2011.05.004
   Rigamonti AE, 2002, J ENDOCRINOL, V175, pR1, DOI 10.1677/joe.0.175R001
   Rudolph J, 2007, J MED CHEM, V50, P5202, DOI 10.1021/jm070071+
   Salehi A, 2004, REGUL PEPTIDES, V118, P143, DOI 10.1016/j.regpep.2003.12.001
   Schwenke DO, 2008, ENDOCRINOLOGY, V149, P237, DOI 10.1210/en.2007-0833
   Schwenke DO, 2011, PFLUG ARCH EUR J PHY, V462, P397, DOI 10.1007/s00424-011-0992-8
   Serra-Prat M, 2015, J NUTR HEALTH AGING, V19, P669, DOI 10.1007/s12603-015-0550-8
   Shearman LP, 2006, ENDOCRINOLOGY, V147, P1517, DOI 10.1210/en.2005-0993
   Shi LM, 2017, MOL NEUROBIOL, V54, P1144, DOI 10.1007/s12035-016-9729-1
   Shibata N, 2011, DEMENT GERIATR COGN, V32, P178, DOI 10.1159/000333075
   Shimizu Y, 2003, CLIN CANCER RES, V9, P774
   Shin A, 2013, DIABETES CARE, V36, P41, DOI 10.2337/dc12-1128
   Shin YK, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012729
   Shindo T, 2009, DIGESTION, V79, P65, DOI 10.1159/000205740
   Skibicka KP, 2011, NEUROSCIENCE, V180, P129, DOI 10.1016/j.neuroscience.2011.02.016
   Skibicka KP, 2013, NEUROPHARMACOLOGY, V73, P274, DOI 10.1016/j.neuropharm.2013.06.004
   Soeki T, 2008, AM J PHYSIOL-HEART C, V294, pH426, DOI 10.1152/ajpheart.00643.2007
   Soriano-Guillén L, 2004, J PEDIATR-US, V144, P36, DOI 10.1016/j.jpeds.2003.10.036
   Souza-Moreira L, 2013, BRAIN BEHAV IMMUN, V30, P54, DOI 10.1016/j.bbi.2013.01.080
   Spencer SJ, 2012, BIOL PSYCHIAT, V72, P457, DOI 10.1016/j.biopsych.2012.03.010
   Spitznagel MB, 2010, PSYCHIAT CLIN NEUROS, V64, P608, DOI 10.1111/j.1440-1819.2010.02145.x
   Steiger A, 2007, AM J PHYSIOL-REG I, V292, P2006, DOI 10.1152/ajpregu.00618.2006
   Strasser F, 2008, BRIT J CANCER, V98, P300, DOI 10.1038/sj.bjc.6604148
   Stylianou C, 2007, J CYST FIBROS, V6, P293, DOI 10.1016/j.jcf.2006.10.011
   Sugiyama M, 2012, REGUL PEPTIDES, V178, P21, DOI 10.1016/j.regpep.2012.06.003
   Sun GX, 2015, J UROLOGY, V193, P2107, DOI 10.1016/j.juro.2014.11.098
   Sun YX, 2008, ENDOCRINOLOGY, V149, P843, DOI 10.1210/en.2007-0271
   Sun Y, 2006, CELL METAB, V3, P379, DOI 10.1016/j.cmet.2006.04.004
   Sun YX, 2003, MOL CELL BIOL, V23, P7973, DOI 10.1128/MCB.23.22.7973-7981.2003
   Swartz EM, 2014, NEUROGASTROENT MOTIL, V26, P272, DOI 10.1111/nmo.12261
   Szentirmai É, 2007, AM J PHYSIOL-REG I, V292, pR575, DOI 10.1152/ajpregu.00448.2006
   Tack J, 2006, GUT, V55, P327, DOI 10.1136/gut.2004.060426
   Takata A, 2015, ANN SURG, V262, P230, DOI 10.1097/SLA.0000000000000986
   Takayama K, 2016, SUPPORT CARE CANCER, V24, P3495, DOI 10.1007/s00520-016-3144-z
   Takeda R, 2006, J AM SOC NEPHROL, V17, P113, DOI 10.1681/ASN.2004080626
   Tanaka M, 2003, PSYCHONEUROENDOCRINO, V28, P829, DOI 10.1016/S0306-4530(02)00066-5
   Temel JS, 2016, LANCET ONCOL, V17, P519, DOI 10.1016/S1470-2045(15)00558-6
   Tesauro M, 2005, CIRCULATION, V112, P2986, DOI 10.1161/CIRCULATIONAHA.105.553883
   Theander-Carrillo C, 2006, J CLIN INVEST, V116, P1983, DOI 10.1172/JCI25811
   Theil MM, 2009, J IMMUNOL, V183, P2859, DOI 10.4049/jimmunol.0803362
   Thompson NM, 2004, ENDOCRINOLOGY, V145, P234, DOI 10.1210/en.2003-0899
   Tolle V, 2003, J CLIN ENDOCR METAB, V88, P109, DOI 10.1210/jc.2002-020645
   Toshinai K, 2006, ENDOCRINOLOGY, V147, P2306, DOI 10.1210/en.2005-1357
   Toshinai K, 2001, BIOCHEM BIOPH RES CO, V281, P1220, DOI 10.1006/bbrc.2001.4518
   Trudel L, 2002, AM J PHYSIOL-GASTR L, V282, pG948, DOI 10.1152/ajpgi.00339.2001
   Tschöp M, 2000, NATURE, V407, P908, DOI 10.1038/35038090
   Tschöp M, 2001, J ENDOCRINOL INVEST, V24, pRC19, DOI 10.1007/BF03351037
   Tsubouchi H, 2014, EUR J PHARMACOL, V743, P1, DOI 10.1016/j.ejphar.2014.09.025
   Unger MM, 2013, NEUROENDOCRINOL LETT, V34, P14
   Unger MM, 2011, J NEUROL, V258, P982, DOI 10.1007/s00415-010-5864-1
   Uzum AK, 2014, EUR J INTERN MED, V25, P364, DOI 10.1016/j.ejim.2013.02.012
   Velásquez DA, 2011, DIABETES, V60, P1177, DOI 10.2337/db10-0802
   Vestergaard ET, 2017, SCI REP-UK, V7, DOI 10.1038/srep42706
   Vestergaard ET, 2007, AM J PHYSIOL-HEART C, V293, pH3020, DOI 10.1152/ajpheart.00496.2007
   Wang H, 2016, INFLAMMATION, V39, P190, DOI 10.1007/s10753-015-0238-6
   Wang W, 2006, INT J ONCOL, V28, P1393
   Wei XJ, 2015, NEUROSCIENCE, V300, P53, DOI 10.1016/j.neuroscience.2015.05.001
   Willesen MG, 1999, NEUROENDOCRINOLOGY, V70, P306, DOI 10.1159/000054491
   Wo JM, 2011, ALIMENT PHARM THER, V33, P679, DOI 10.1111/j.1365-2036.2010.04567.x
   Wortley KE, 2004, P NATL ACAD SCI USA, V101, P8227, DOI 10.1073/pnas.0402763101
   Wortley KE, 2005, J CLIN INVEST, V115, P3573, DOI 10.1172/JCI26003
   Wren AM, 2000, ENDOCRINOLOGY, V141, P4325, DOI 10.1210/en.141.11.4325
   Wren AM, 2001, J CLIN ENDOCR METAB, V86, P5992, DOI 10.1210/jc.86.12.5992
   Wu Q, 2012, P NATL ACAD SCI USA, V109, P3155, DOI 10.1073/pnas.1120501109
   Wu R, 2007, AM J RESP CRIT CARE, V176, P805, DOI 10.1164/rccm.200604-511OC
   Wynne K, 2005, J AM SOC NEPHROL, V16, P2111, DOI 10.1681/ASN.2005010039
   Xu YP, 2011, J MOL ENDOCRINOL, V47, P33, DOI 10.1530/JME-10-0143
   Xu Zhi-song, 2012, Zhonghua Nei Ke Za Zhi, V51, P536
   Yang CY, 2012, J CARDIOVASC PHARM, V59, P465, DOI 10.1097/FJC.0b013e31824a7b60
   Yang D, 2013, PEPTIDES, V42, P112, DOI 10.1016/j.peptides.2013.01.012
   Yang J, 2008, CELL, V132, P387, DOI 10.1016/j.cell.2008.01.017
   Yang SF, 2016, SCI REP-UK, V6, DOI 10.1038/srep26605
   Yasuda T, 2003, NEUROSCI LETT, V349, P75, DOI 10.1016/S0304-3940(03)00789-4
   Ying BW, 2008, J INT MED RES, V36, P1371, DOI 10.1177/147323000803600626
   Yoshimoto A, 2002, J AM SOC NEPHROL, V13, P2748, DOI 10.1097/01.ASN.0000032420.12455.74
   Yu JH, 2016, NEUROPEPTIDES, V56, P69, DOI 10.1016/j.npep.2015.09.011
   Zeng M, 2015, INFLAMMATION, V38, P683, DOI 10.1007/s10753-014-9977-z
   Zhang GG, 2013, PEPTIDES, V48, P156, DOI 10.1016/j.peptides.2013.08.015
   Zhang WZ, 2008, ENDOCRINOLOGY, V149, P4710, DOI 10.1210/en.2008-0263
   Zhao TJ, 2010, P NATL ACAD SCI USA, V107, P7467, DOI 10.1073/pnas.1002271107
   Zheng YC, 2013, PLOS ONE, V8, DOI [10.1371/journal.pone.0080122, 10.1371/journal.pone.0069868]
   Zhou XL, 2010, AM J MED SCI, V339, P49, DOI 10.1097/MAJ.0b013e3181b9c3d3
   Zigman JM, 2006, J COMP NEUROL, V494, P528, DOI 10.1002/cne.20823
   Zigman JM, 2005, J CLIN INVEST, V115, P3564, DOI 10.1172/JCI26002
   Zorrilla EP, 2006, P NATL ACAD SCI USA, V103, P13226, DOI 10.1073/pnas.0605376103
NR 300
TC 113
Z9 125
U1 2
U2 36
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2017
VL 18
IS 4
AR 798
DI 10.3390/ijms18040798
PG 29
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA EW6SA
UT WOS:000402639400122
PM 28398233
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Luciano, TF
   de Souza, CT
   de Oliveira, J
   Müller, AP
AF Luciano, Thais Fernandes
   Teodoro de Souza, Claudio
   de Oliveira, Jade
   Mueller, Alexandre Pastoris
TI Reversal of high-fat diet-induced cognitive impairment and oxidative
   stress in the brain through Zingiber officinale supplementation
SO METABOLIC BRAIN DISEASE
LA English
DT Article
DE Zingiber officinale; Learning and memory; Obesity; Brain metabolism
ID INDUCED NEUROINFLAMMATION; METABOLIC SYNDROME; GINGER; OBESITY; EXTRACT;
   ANXIETY; IMPACT; MICE
AB Obesity is a significant health concern that is correlated with various adverse health outcomes. Diet-induced obesity (DIO) is associated with impaired cognitive function. Pharmacological treatments for obesity are limited and may have serious adverse effects. Zingiber officinale (ZO) has anti-inflammatory and antioxidant effects, in addition to metabolic effects. This study aimed to assess the effects of Zingiber officinale supplementation on cognitive function, anxiety levels, neurotrophin levels, and the inflammatory and oxidative status in the cortex following DIO in mice. Two-month-old male Swiss mice were fed DIO or standard chow for 4 months and subsequently subdivided into the following groups (n = 10 mice/group): (i) control - vehicle (CNT + vehicle); (ii) CNT supplemented with ZO (CNT + ZO); (iii) obese mice (DIO + vehicle); and (iv) obese mice supplemented with ZO (DIO + ZO) (n = 10). Zingiber officinale extract (400 mg/kg/day) was administered for 35 days via oral gavage. The DIO + vehicle group exhibited impaired recognition memory. The CNT + ZO group presented a greater number of crossings in the open field. No difference between the groups was observed in the plus maze test. DIO + vehicle increased the DCFH and carbonylation levels in the cortex. The DIO + vehicle group presented a reduction in catalase activity. The expression of inflammatory or neurotrophin markers in the cerebral cortex was not different. In conclusion, our findings indicate that supplementation with ZO reverses the cognitive impairment in DIO mice and enhances the antioxidant status of the cerebral cortex.
C1 [Luciano, Thais Fernandes] Univ Extremo Catarinense UNESC, Postgrad Program Hlth Sci, Criciuma, SC, Brazil.
   [Teodoro de Souza, Claudio] Fed Univ Juiz Fora UFJF, Med Sch, Dept Internal Med, Postgrad Program Hlth, Juiz De Fora, MG, Brazil.
   [de Oliveira, Jade] Univ Fed Rio Grande UFRGS, Dept Bioquim, Programa Pos Grad Ciencias Biologicas: Bioquim, Inst Ciencias Bas Saude ICBS, Porto Alegre, RS, Brazil.
   [Mueller, Alexandre Pastoris] Fed Univ Santa Catarina UFSC, Dept Biochem, Postgrad Program Biochem, Florianopolis, SC, Brazil.
   [Mueller, Alexandre Pastoris] Fed Univ Santa Catarina UFSC, Postgrad Program Pharmacol, Florianopolis, SC, Brazil.
C3 Universidade Federal de Juiz de Fora; Universidade Federal do Rio Grande
   do Sul; Universidade Federal de Santa Catarina (UFSC); Universidade
   Federal de Santa Catarina (UFSC)
RP Müller, AP (corresponding author), Fed Univ Santa Catarina UFSC, Dept Biochem, Postgrad Program Biochem, Florianopolis, SC, Brazil.
EM bionutrithais@gmail.com; claudio.t.desouza@gmail.com;
   deoliveirajade10@gmail.com; alexandrep.muller@gmail.com
RI de Oliveira, Jade/AAJ-6849-2020
OI Muller, alexandre/0000-0002-9961-8614
FU Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico
FX No Statement Available
CR Baker KD, 2017, NEUROSCI BIOBEHAV R, V83, P173, DOI 10.1016/j.neubiorev.2017.10.014
   Bocarsly ME, 2015, P NATL ACAD SCI USA, V112, P15731, DOI 10.1073/pnas.1511593112
   Cavaliere G, 2019, FRONT CELL NEUROSCI, V13, DOI 10.3389/fncel.2019.00509
   Cherbuin N, 2012, NEUROLOGY, V79, P1019, DOI 10.1212/WNL.0b013e31826846de
   Choi JG, 2018, PHARMACOL THERAPEUT, V182, P56, DOI 10.1016/j.pharmthera.2017.08.010
   de Oliveira J, 2020, J ALZHEIMERS DIS, V78, P97, DOI 10.3233/JAD-200541
   de Paula GC, 2021, FRONT NEUROSCI-SWITZ, V15, DOI 10.3389/fnins.2021.734158
   de Souza KR, 2024, METAB BRAIN DIS, V39, P635, DOI 10.1007/s11011-023-01311-6
   Denver P, 2018, DIABETES OBES METAB, V20, P1166, DOI 10.1111/dom.13210
   Feng MY, 2019, NEUROSCIENCE, V406, P109, DOI 10.1016/j.neuroscience.2019.03.003
   Gabriel MO, 2020, BEHAV BRAIN RES, V380, DOI 10.1016/j.bbr.2019.112419
   Gancheva S, 2017, INT J EXP PATHOL, V98, P296, DOI 10.1111/iep.12254
   Grzanna R, 2005, J MED FOOD, V8, P125, DOI 10.1089/jmf.2005.8.125
   Guillemot-Legris O, 2017, TRENDS NEUROSCI, V40, P237, DOI 10.1016/j.tins.2017.02.005
   Hasenohrl RU, 1996, PHARMACOL BIOCHEM BE, V53, P271, DOI 10.1016/0091-3057(95)02001-2
   Haslam DW, 2005, LANCET, V366, P1197, DOI 10.1016/S0140-6736(05)67483-1
   Hryhorczuk C, 2017, PSYCHONEUROENDOCRINO, V83, P142, DOI 10.1016/j.psyneuen.2017.06.002
   Jang HM, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201800978
   Khaliq S, 2017, PAK J PHARM SCI, V30, P2061
   Kim CY, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/8941564
   Kim D, 2017, MED SCI SPORT EXER, V49, P676, DOI [10.1249/mss.0000000000001166, 10.1249/MSS.0000000000001166]
   Kim JD, 2019, CELL METAB, V30, P952, DOI 10.1016/j.cmet.2019.08.010
   Lim S, 2014, J NUTR BIOCHEM, V25, P1058, DOI 10.1016/j.jnutbio.2014.05.009
   Luciano TF, 2021, BRIT J NUTR, V126, P970, DOI 10.1017/S0007114520005073
   Mabrouk DM, 2022, ENVIRON SCI POLLUT R, V29, P87184, DOI 10.1007/s11356-022-21878-4
   Miller AA, 2014, BRAIN BEHAV IMMUN, V42, P10, DOI 10.1016/j.bbi.2014.04.001
   Moorkoth S, 2021, PHARMACOL REP, V73, P1273, DOI 10.1007/s43440-021-00252-0
   Morvaridzadeh M, 2021, J FOOD BIOCHEM, V45, DOI 10.1111/jfbc.13612
   Morvaridzadeh M, 2020, CYTOKINE, V135, DOI 10.1016/j.cyto.2020.155224
   Muller Alexandre Pastoris, 2013, Longev Healthspan, V2, P10, DOI 10.1186/2046-2395-2-10
   Nammi S, 2009, BASIC CLIN PHARMACOL, V104, P366, DOI 10.1111/j.1742-7843.2008.00362.x
   Oliveras-Cañellas N, 2023, SCI ADV, V9, DOI 10.1126/sciadv.adg4017
   Pagano E, 2021, PHYTOTHER RES, V35, P2403, DOI 10.1002/ptr.6964
   Palatty PL, 2013, CRIT REV FOOD SCI, V53, P659, DOI 10.1080/10408398.2011.553751
   Park HR, 2010, NEUROSCI LETT, V482, P235, DOI 10.1016/j.neulet.2010.07.046
   Pasinetti GM, 2008, J NEUROCHEM, V106, P1503, DOI 10.1111/j.1471-4159.2008.05454.x
   Pedroso JAB, 2016, ENDOCRINOLOGY, V157, P3901, DOI 10.1210/en.2016-1038
   Sah N, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-11268-z
   Sahardi NFNM, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/5054395
   Sestakova Natalia, 2013, Interdiscip Toxicol, V6, P126, DOI 10.2478/intox-2013-0020
   Sharma S, 2021, PHYSIOL BEHAV, V240, DOI 10.1016/j.physbeh.2021.113528
   Suárez J, 2019, PSYCHONEUROENDOCRINO, V110, DOI 10.1016/j.psyneuen.2019.104418
   Talebi M, 2021, BIOMED PHARMACOTHER, V133, DOI 10.1016/j.biopha.2020.111088
   Tramontin ND, 2021, ULTRASOUND MED BIOL, V47, P2646, DOI 10.1016/j.ultrasmedbio.2021.05.007
   Tramontin ND, 2020, PHYTOTHER RES, V34, P1282, DOI 10.1002/ptr.6619
   Valenzuela PL, 2023, NAT REV CARDIOL, V20, P475, DOI 10.1038/s41569-023-00847-5
   Vishwakarma SL, 2002, PHYTOTHER RES, V16, P621, DOI 10.1002/ptr.948
   Wang JX, 2021, NEUROCHEM INT, V148, DOI 10.1016/j.neuint.2021.105098
   Wattanathorn J, 2011, EVID-BASED COMPL ALT, V2011, P1, DOI 10.1155/2011/429505
   Zarei M, 2021, METAB BRAIN DIS, V36, P225, DOI 10.1007/s11011-020-00642-y
   Zhang F, 2018, BIOMED PHARMACOTHER, V107, P1523, DOI 10.1016/j.biopha.2018.08.136
NR 51
TC 1
Z9 1
U1 3
U2 5
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0885-7490
EI 1573-7365
J9 METAB BRAIN DIS
JI Metab. Brain Dis.
PD DEC
PY 2024
VL 39
IS 8
BP 1495
EP 1503
DI 10.1007/s11011-024-01406-8
EA AUG 2024
PG 9
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA L1N6T
UT WOS:001288063700001
PM 39120852
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Koenig, G
   Seneff, S
AF Koenig, Gerald
   Seneff, Stephanie
TI Gamma-Glutamyltransferase: A Predictive Biomarker of Cellular
   Antioxidant Inadequacy and Disease Risk
SO DISEASE MARKERS
LA English
DT Review
ID CHRONIC KIDNEY-DISEASE; SERUM FERRITIN LEVELS; FATTY LIVER-DISEASE;
   YOUNG-ADULTS; METABOLIC SYNDROME; OXIDATIVE-STRESS;
   CARDIOVASCULAR-DISEASE; KOREAN MEN; INSULIN-RESISTANCE; CANCER INCIDENCE
AB Gamma-glutamyltransferase (GGT) is a well-established serum marker for alcohol-related liver disease. However, GGT's predictive utility applies well beyond liver disease: elevated GGT is linked to increased risk to a multitude of diseases and conditions, including cardiovascular disease, diabetes, metabolic syndrome (MetS), and all-cause mortality. The literature from multiple population groups worldwide consistently shows strong predictive power for GGT, even across different gender and ethnic categories. Here, we examine the relationship of GGT to other serum markers such as serum ferritin (SF) levels, and we suggest a link to exposure to environmental and endogenous toxins, resulting in oxidative and nitrosative stress. We observe a general upward trend in population levels of GGT over time, particularly in the US and Korea. Since the late 1970s, both GGT and incident MetS and its related disorders have risen in virtual lockstep. GGT is an early predictive marker for atherosclerosis, heart failure, arterial stiffness and plaque, gestational diabetes, and various liver diseases, including viral hepatitis, other infectious diseases, and several life-threatening cancers. We review literature both from the medical sciences and from life insurance industries demonstrating that serum GGT is a superior marker for future disease risk, when compared against multiple other known mortality risk factors.
C1 [Koenig, Gerald] Hlth E Iron LLC, Austin, TX 78746 USA.
   [Koenig, Gerald] Iron Disorders Inst, Greenville, SC 29615 USA.
   [Seneff, Stephanie] MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02139 USA.
C3 Massachusetts Institute of Technology (MIT)
RP Koenig, G (corresponding author), Hlth E Iron LLC, 2800 Waymaker Way 12, Austin, TX 78746 USA.
EM gerrykoenigtx@aol.com
OI Seneff, Stephanie/0000-0001-8191-1049
FU Quanta Computers, Taipei, Taiwan, under the auspices of the Qmulus
   Project
FX This research was funded in part by Quanta Computers, Taipei, Taiwan,
   under the auspices of the Qmulus Project.
CR Abdalla MY, 2011, HEMOGLOBIN, V35, P67, DOI 10.3109/03630269.2010.544624
   Aberkane H, 2002, EUR J HAEMATOL, V68, P262, DOI 10.1034/j.1600-0609.2002.01636.x
   Acton RT, 2006, DIABETES CARE, V29, P2084, DOI 10.2337/dc05-1592
   Alam S, 2013, WORLD J HEPATOL, V5, P281, DOI 10.4254/wjh.v5.i5.281
   Amiri Fatemeh Nasiri, 2013, J Nat Sci Biol Med, V4, P302, DOI 10.4103/0976-9668.116977
   [Anonymous], 2011, Serum ferritin concentrations for the assessment of iron status and iron deficiency in populations
   [Anonymous], 2015, Science Daily
   [Anonymous], 2015, PUBLIC SERVICE CLIN
   [Anonymous], GUT
   Atar AI, 2013, INT J CARDIOL, V167, P1264, DOI 10.1016/j.ijcard.2012.03.157
   Badria FA, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0134156
   Baillie-Hamilton PF, 2002, J ALTERN COMPLEM MED, V8, P185, DOI 10.1089/107555302317371479
   Bonkovsky HL, 2006, GASTROENTEROLOGY, V131, P1440, DOI 10.1053/j.gastro.2006.08.036
   Brown KE, 1998, FREE RADICAL BIO MED, V24, P545, DOI 10.1016/S0891-5849(97)00284-0
   Buettner GR, 1996, RADIAT RES, V145, P532, DOI 10.2307/3579271
   Calle EE, 2003, NEW ENGL J MED, V348, P1625, DOI 10.1056/NEJMoa021423
   Celik O, 2014, CLIN CARDIOL, V37, P552, DOI 10.1002/clc.22307
   Chuengsamarn S, 2012, DIABETES CARE, V35, P2121, DOI 10.2337/dc12-0116
   Chun H, 2013, J KOREAN MED SCI, V28, P1603, DOI 10.3346/jkms.2013.28.11.1603
   Corti A, 2009, MUTAT RES-FUND MOL M, V669, P112, DOI 10.1016/j.mrfmmm.2009.05.010
   Dhingra R, 2010, ARTERIOSCL THROM VAS, V30, P1855, DOI 10.1161/ATVBAHA.110.207340
   Eminler AT, 2014, TURK J GASTROENTEROL, V25, P411, DOI 10.5152/tjg.2014.3693
   Everhart JE, 2013, HEPATOLOGY, V57, P1725, DOI 10.1002/hep.26203
   Gautier A, 2010, DIABETOLOGIA, V53, P247, DOI 10.1007/s00125-009-1602-6
   Gonzalez MC, 2014, AM J CLIN NUTR, V99, P999, DOI 10.3945/ajcn.113.071399
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hendriks HFJ, 2003, EUR J CLIN NUTR, V57, P681, DOI 10.1038/sj.ejcn.1601598
   Himmelfarb J, 2002, KIDNEY INT, V62, P1524, DOI 10.1046/j.1523-1755.2002.00600.x
   Javadian Pouya, 2014, Acta Med Iran, V52, P385
   Jenkins B, 2015, MOLECULES, V20, P2425, DOI 10.3390/molecules20022425
   Johnson SP, 2009, JAVMA-J AM VET MED A, V235, P194, DOI 10.2460/javma.235.2.194
   Kamalakkannan N, 2005, BASIC CLIN PHARMACOL, V97, P15, DOI 10.1111/j.1742-7843.2005.pto_97103.x
   Kazemi-Shirazi L, 2007, CLIN CHEM, V53, P940, DOI 10.1373/clinchem.2006.081620
   Kim KN, 2011, J KOREAN MED SCI, V26, P1305, DOI 10.3346/jkms.2011.26.10.1305
   Lambrecht RW, 2011, GASTROENTEROLOGY, V140, P1490, DOI 10.1053/j.gastro.2011.01.053
   Lee DH, 2008, DIABETOLOGIA, V51, P402, DOI 10.1007/s00125-007-0896-5
   Lee DH, 2006, ENVIRON HEALTH PERSP, V114, P350, DOI 10.1289/ehp.8518
   Lee DH, 2006, AM J EPIDEMIOL, V163, P57, DOI 10.1093/aje/kwj006
   Lee DH, 2005, ATHEROSCLEROSIS, V178, P327, DOI 10.1016/j.atherosclerosis.2004.08.027
   Lee DH, 2004, CLIN CHEM, V50, P582, DOI 10.1373/clinchem.2003.028852
   Lee DH, 2004, FREE RADICAL RES, V38, P535, DOI 10.1080/10715760410001694026
   Lee DH, 2004, AM J CLIN NUTR, V79, P600
   Lee DS, 2007, ARTERIOSCL THROM VAS, V27, P127, DOI 10.1161/01.ATV.0000251993.20372.40
   Lee DH, 2006, EUR HEART J, V27, P2170, DOI 10.1093/eurheartj/ehl086
   Lee DH, 2009, CLIN CHEM LAB MED, V47, P860, DOI 10.1515/CCLM.2009.197
   Lee W, 2013, ATHEROSCLEROSIS, V226, P269, DOI 10.1016/j.atherosclerosis.2012.10.059
   Lim JS, 2004, FREE RADICAL BIO MED, V37, P1018, DOI 10.1016/j.freeradbiomed.2004.06.032
   LUM G, 1974, ANN CLIN LAB SCI, V4, P13
   McElroy AK, 2014, J INFECT DIS, V210, P558, DOI 10.1093/infdis/jiu088
   Milnerowicz H, 2014, MEDIAT INFLAMM, V2014, DOI 10.1155/2014/376518
   Minear S, 2011, EUKARYOT CELL, V10, P1574, DOI 10.1128/EC.05163-11
   Mok Y., 2015, INT J CANC
   Montonen J, 2013, EUR J NUTR, V52, P337, DOI 10.1007/s00394-012-0340-6
   Moyo VM, 2009, ANN HEMATOL, V88, P1131, DOI 10.1007/s00277-009-0718-6
   Myers RP, 2003, J HEPATOL, V39, P222, DOI 10.1016/S0168-8278(03)00171-5
   Pham NM, 2011, CLIN CHEM LAB MED, V49, P1661, DOI 10.1515/CCLM.2011.652
   Nie W, 2014, BMC MED, V12, DOI 10.1186/1741-7015-12-61
   Olesnevich M. E., 2012, PUBLIC HEALTH NUTR, V15
   Olesnevich ME, 2012, PUBLIC HEALTH NUTR, V15, P1291, DOI 10.1017/S1368980011003284
   Palmier J., 2012, LEADING CONTRIBUTORS
   Palmier James, 2012, J Insur Med, V43, P162
   Pan Y, 2008, AM J HUM BIOL, V20, P406, DOI 10.1002/ajhb.20745
   Paolicchi A, 2002, BIOCHEM PHARMACOL, V64, P1027, DOI 10.1016/S0006-2952(02)01173-5
   Park SK, 2014, ENDOCR J, V61, P215, DOI 10.1507/endocrj.EJ13-0173
   Park SK, 2012, DIABETES CARE, V35, P2521, DOI 10.2337/dc12-0543
   Park WY, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000001249
   Patel DA, 2007, METABOLISM, V56, P792, DOI 10.1016/j.metabol.2007.01.010
   Pereira MA, 2002, JAMA-J AM MED ASSOC, V287, P2081, DOI 10.1001/jama.287.16.2081
   Perry IJ, 1998, DIABETES CARE, V21, P732, DOI 10.2337/diacare.21.5.732
   Postorino M, 2008, KIDNEY INT, V74, pS64, DOI 10.1038/ki.2008.515
   Ruhl CE, 2009, GASTROENTEROLOGY, V136, P477, DOI 10.1053/j.gastro.2008.10.052
   Rukkumani R, 2004, J PHARM PHARM SCI, V7, P274
   Ruttmann E, 2005, CIRCULATION, V112, P2130, DOI 10.1161/CIRCULATIONAHA.105.552547
   Ryoo JH, 2014, DIABETIC MED, V31, P455, DOI 10.1111/dme.12315
   Ryu S, 2007, CLIN CHEM, V53, P71, DOI 10.1373/clinchem.2006.078980
   Sartori M, 2011, EUR J GASTROEN HEPAT, V23, P1178, DOI 10.1097/MEG.0b013e328349923c
   Sartori M, 2010, WORLD J GASTROENTERO, V16, P596, DOI 10.3748/wjg.v16.i5.596
   Sreeram Meenakshi, 2015, J Indian Soc Periodontol, V19, P150, DOI 10.4103/0972-124X.149032
   Sridhar SB, 2014, DIABETES CARE, V37, P1878, DOI 10.2337/dc13-2229
   Stefano GB, 2015, ANN TRANSPL, V20, DOI 10.12659/AOT.894289
   Strasak AM, 2008, INT J CANCER, V123, P1902, DOI 10.1002/ijc.23714
   Strasak AM, 2008, CANCER RES, V68, P3970, DOI 10.1158/0008-5472.CAN-07-6686
   Suh BS, 2012, KOREAN J FAM MED, V33, P51, DOI 10.4082/kjfm.2012.33.1.51
   Suh YJ, 2013, ATHEROSCLEROSIS, V227, P437, DOI 10.1016/j.atherosclerosis.2013.01.029
   SULLIVAN JL, 1992, CIRCULATION, V86, P1036, DOI 10.1161/01.CIR.86.3.1036
   SULLIVAN JL, 1981, LANCET, V1, P1293
   Sun K, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0114970
   Sun L, 2008, J CLIN ENDOCR METAB, V93, P4690, DOI 10.1210/jc.2008-1159
   Swaminathan S, 2007, DIABETES CARE, V30, P1926, DOI 10.2337/dc06-2625
   Targher G., 2007, DIABETES CARE, V30
   Teppala S, 2010, KIDNEY BLOOD PRESS R, V33, P1, DOI 10.1159/000274463
   Valenti L, 2014, WORLD J GASTROENTERO, V20, P3002, DOI 10.3748/wjg.v20.i11.3002
   Venn-Watson SK, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0132117
   Wang Y, 2007, EPIDEMIOL REV, V29, P6, DOI 10.1093/epirev/mxm007
   Warren TK, 2014, VIRUSES-BASEL, V6, P4666, DOI 10.3390/v6114666
   Wei D, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/741731
   Whitfield JB, 2001, CRIT REV CL LAB SCI, V38, P263, DOI 10.1080/20014091084227
   Wickham S, 2011, ANAL BIOCHEM, V414, P208, DOI 10.1016/j.ab.2011.03.026
   World Health Organization, 2015, care and treatment for people with chronic hepatitis B infection
   Zacharski LR, 2000, AM HEART J, V140, P98, DOI 10.1067/mhj.2000.106646
   Zein S, 2015, J TRACE ELEM MED BIO, V30, P220, DOI 10.1016/j.jtemb.2014.09.004
   Zhan YQ, 2014, ACTA DIABETOL, V51, P991, DOI 10.1007/s00592-014-0656-1
   Zhuang TF, 2014, NUTRIENTS, V6, P3968, DOI 10.3390/nu6093968
NR 103
TC 228
Z9 243
U1 2
U2 30
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0278-0240
EI 1875-8630
J9 DIS MARKERS
JI Dis. Markers
PY 2015
VL 2015
BP 1
EP 18
AR 818570
DI 10.1155/2015/818570
PG 18
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine,
   Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research &
   Experimental Medicine; Pathology
GA CU5UA
UT WOS:000363596300001
PM 26543300
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Coccurello, R
   D'Amato, FR
   Moles, A
AF Coccurello, Roberto
   D'Amato, Francesca R.
   Moles, Anna
TI Chronic social stress, hedonism and vulnerability to obesity: Lessons
   from Rodents
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Social stress; Food intake; Reward; CART; Obesity; Rodents
ID AMPHETAMINE-REGULATED TRANSCRIPT; CORTICOTROPIN-RELEASING-FACTOR;
   11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; PITUITARY-ADRENAL AXIS;
   INDUCED BEHAVIORAL SENSITIZATION; NEONATAL MATERNAL SEPARATION; HEPATIC
   INSULIN SENSITIVITY; COCAINE-SEEKING BEHAVIOR; NUCLEUS-ACCUMBENS SHELL;
   LONG-EVANS RATS
AB Obesity is a current health pandemia. Determinants of this pathology are rather complex and include genetic, developmental and environmental factors only partially disclosed. Stress related neuroendocrine dysregulation and overconsumption of high palatable high caloric food and are likely to contribute to this modern health threats. Despite the evidence that psychosocial stress is one of the main sources of stress in humans and may play an important role in the development of the stress disorders, including obesity and metabolic syndrome, animal models focusing on the relationship between chronic stress and energy homeostasis are scattered and most of them encompasses physical rather than psychosocial stress. Aim of the present paper is to review rodent studies on the effect of psychosocial stress throughout life on body weight and food intake regulation. In the second part of the review special focus will be given on the mechanisms linking stress and the reward system. (C) 2008 Elsevier Ltd. All rights reserved.
C1 [Coccurello, Roberto; D'Amato, Francesca R.; Moles, Anna] CNR, Inst Neurosci, I-00143 Rome, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR)
RP Moles, A (corresponding author), CNR, Inst Neurosci, Via Fosso di Fiorano 64-65, I-00143 Rome, Italy.
EM anna.moles@ipsifar.rm.cnr.it
RI Coccurello, Roberto/F-8460-2015
OI Moles, Anna/0000-0002-5805-5763; D'Amato, Francesca/0000-0002-4577-4574;
   COCCURELLO, ROBERTO/0000-0001-7059-7015
CR Abbott CR, 2001, ENDOCRINOLOGY, V142, P3457, DOI 10.1210/en.142.8.3457
   Andrews RC, 2002, J CLIN ENDOCR METAB, V87, P5587, DOI 10.1210/jc.2002-020048
   [Anonymous], 2000, HLTH PEOPL 2010, V2nd
   Arborelius L, 1999, J ENDOCRINOL, V160, P1, DOI 10.1677/joe.0.1600001
   Archer ZA, 2005, J NEUROENDOCRINOL, V17, P711, DOI 10.1111/j.1365-2826.2005.01363.x
   ARCHER ZA, 2001, J NEUROENDOCRINOL, V17, P10
   Baldo BA, 2004, EUR J NEUROSCI, V19, P376, DOI 10.1111/j.1460-9568.2004.03093.x
   Balfour ME, 2004, NEUROPSYCHOPHARMACOL, V29, P718, DOI 10.1038/sj.npp.1300350
   Balkan B, 2001, BRAIN RES, V917, P15, DOI 10.1016/S0006-8993(01)02899-2
   Bartolomucci A, 2001, PHYSIOL BEHAV, V73, P401, DOI 10.1016/S0031-9384(01)00453-X
   Bartolomucci A, 2004, PSYCHONEUROENDOCRINO, V29, P899, DOI 10.1016/j.psyneuen.2003.08.003
   Bartolomucci A, 2007, FRONT NEUROENDOCRIN, V28, P28, DOI 10.1016/j.yfrne.2007.02.001
   BERENDSE HW, 1990, J COMP NEUROL, V299, P187, DOI 10.1002/cne.902990206
   Berridge KC, 1998, BRAIN RES REV, V28, P309, DOI 10.1016/S0165-0173(98)00019-8
   Berridge KC, 1996, NEUROSCI BIOBEHAV R, V20, P1, DOI 10.1016/0149-7634(95)00033-B
   Berton O, 1998, NEUROSCIENCE, V82, P147
   Bhatnagar S, 2006, J NEUROENDOCRINOL, V18, P13, DOI 10.1111/j.1365-2826.2005.01375.x
   Bhatnagar S, 2003, HORM BEHAV, V43, P158, DOI 10.1016/S0018-506X(02)00011-9
   Bjorntorp P, 1996, INT J OBESITY, V20, P973
   BLANCHARD DC, 1995, PSYCHONEUROENDOCRINO, V20, P117, DOI 10.1016/0306-4530(94)E0045-B
   BORER KT, 1988, AM J PHYSIOL, V255, pR128, DOI 10.1152/ajpregu.1988.255.1.R128
   Bouret SG, 2006, CLIN GENET, V70, P295, DOI 10.1111/j.1399-0004.2006.00684.x
   Bowman EM, 1996, J NEUROPHYSIOL, V75, P1061, DOI 10.1152/jn.1996.75.3.1061
   Broberger C, 1999, BRAIN RES, V848, P101, DOI 10.1016/S0006-8993(99)01977-0
   Bujalska IJ, 1999, ENDOCRINOLOGY, V140, P3188, DOI 10.1210/en.140.7.3188
   Bujalska IJ, 1997, LANCET, V349, P1210, DOI 10.1016/S0140-6736(96)11222-8
   Buwalda B, 2001, PHYSIOL BEHAV, V73, P371, DOI 10.1016/S0031-9384(01)00493-0
   CABIB S, 1993, BRAIN RES, V604, P232, DOI 10.1016/0006-8993(93)90374-V
   Carelli RM, 2002, PHYSIOL BEHAV, V76, P379, DOI 10.1016/S0031-9384(02)00760-6
   CARELLI RM, 1994, J NEUROSCI, V14, P7735
   CARPENTER WT, 1971, AM J PSYCHIAT, V128, P31, DOI 10.1176/ajp.128.1.31
   Chan O, 2003, Minerva Endocrinol, V28, P87
   Chapillon P, 2002, DEV PSYCHOBIOL, V41, P373, DOI 10.1002/dev.10066
   CIRULLI F, 1994, DEV PSYCHOBIOL, V27, P301, DOI 10.1002/dev.420270505
   Cota D, 2006, BRAIN RES REV, V51, P85, DOI 10.1016/j.brainresrev.2005.10.004
   Covington HE, 2005, PSYCHOPHARMACOLOGY, V183, P331, DOI 10.1007/s00213-005-0190-5
   Covington HE, 2001, PSYCHOPHARMACOLOGY, V158, P388, DOI 10.1007/s002130100858
   D'Amato FR, 1999, DEV BRAIN RES, V117, P15, DOI 10.1016/S0165-3806(99)00090-5
   D'Amato FR, 2007, PHARMACOL BIOCHEM BE, V87, P122, DOI 10.1016/j.pbb.2007.04.008
   Dall Vechia S, 2000, J COMP NEUROL, V416, P291, DOI 10.1002/(SICI)1096-9861(20000117)416:3<291::AID-CNE2>3.0.CO;2-E
   Dallman MF, 1995, ANN NY ACAD SCI, V771, P730, DOI 10.1111/j.1749-6632.1995.tb44724.x
   Dallman MF, 2005, BRAIN BEHAV IMMUN, V19, P275, DOI 10.1016/j.bbi.2004.11.004
   Dallman MF, 2004, ENDOCRINOLOGY, V145, P2633, DOI 10.1210/en.2004-0037
   Dallman MF, 2003, P NATL ACAD SCI USA, V100, P11696, DOI 10.1073/pnas.1934666100
   Dallvechia-Adams S, 2001, J COMP NEUROL, V434, P29, DOI 10.1002/cne.1162
   Davis C, 2004, APPETITE, V42, P131, DOI 10.1016/j.appet.2003.07.004
   De Kloet ER, 1998, ENDOCR REV, V19, P269, DOI 10.1210/er.19.3.269
   Dent GW, 2000, ENDOCRINOLOGY, V141, P1593, DOI 10.1210/en.141.5.1593
   Dess NK, 1998, J EXP PSYCHOL-ANIM B, V24, P60, DOI 10.1037/0097-7403.24.1.60
   Dhillo WS, 2002, J NEUROENDOCRINOL, V14, P725, DOI 10.1046/j.1365-2826.2002.00832.x
   DICHIARA G, 1988, P NATL ACAD SCI USA, V85, P5274
   DOUGLASS J, 1995, J NEUROSCI, V15, P2471
   Drewnowski A, 2004, AM J CLIN NUTR, V79, P6
   Elias CF, 1998, NEURON, V21, P1375, DOI 10.1016/S0896-6273(00)80656-X
   Everitt BJ, 2001, BRAIN RES REV, V36, P129, DOI 10.1016/S0165-0173(01)00088-1
   Flegal KM, 2002, JAMA-J AM MED ASSOC, V288, P1723, DOI 10.1001/jama.288.14.1723
   FLETCHER JM, 1986, HORM METAB RES, V18, P290, DOI 10.1055/s-2007-1012299
   Foster MT, 2006, AM J PHYSIOL-REG I, V290, pR1284, DOI 10.1152/ajpregu.00437.2005
   Francis D, 1996, ANN NY ACAD SCI, V794, P136, DOI 10.1111/j.1749-6632.1996.tb32517.x
   Fuchs E, 1996, PHARMACOL BIOCHEM BE, V54, P219, DOI 10.1016/0091-3057(95)02166-3
   GIBBONS JL, 1962, J PSYCHIATR RES, V1, P162, DOI 10.1016/0022-3956(62)90006-7
   GIBSON MJ, 1981, NEUROPEPTIDES, V1, P349, DOI 10.1016/0143-4179(81)90022-6
   Gluckman PD, 2007, J INTERN MED, V261, P461, DOI 10.1111/j.1365-2796.2007.01802.x
   Gluckman PD, 2005, P ROY SOC B-BIOL SCI, V272, P671, DOI 10.1098/rspb.2004.3001
   Goeders NE, 2002, PSYCHONEUROENDOCRINO, V27, P13, DOI 10.1016/S0306-4530(01)00034-8
   GUILLAUMEGENTIL C, 1990, ENDOCRINOLOGY, V126, P1873, DOI 10.1210/endo-126-4-1873
   Hajnal A, 2004, AM J PHYSIOL-REG I, V286, pR31, DOI 10.1152/ajpregu.00282.2003
   Haller J, 1999, BRAIN RES BULL, V50, P33, DOI 10.1016/S0361-9230(99)00087-8
   HAUNER H, 1987, J CLIN ENDOCR METAB, V64, P832, DOI 10.1210/jcem-64-4-832
   HEIMER L, 1991, NEUROSCIENCE, V41, P89, DOI 10.1016/0306-4522(91)90202-Y
   Heinrichs SC, 1999, NEUROPEPTIDES, V33, P350, DOI 10.1054/npep.1999.0047
   Holland PC, 2005, PHYSIOL BEHAV, V86, P747, DOI 10.1016/j.physbeh.2005.08.062
   Hollerman JR, 1998, J NEUROPHYSIOL, V80, P947, DOI 10.1152/jn.1998.80.2.947
   Howes SR, 2000, PSYCHOPHARMACOLOGY, V151, P55, DOI 10.1007/s002130000451
   Hunter RG, 2005, EUR J PHARMACOL, V517, P45, DOI 10.1016/j.ejphar.2005.05.025
   Huot RL, 2001, PSYCHOPHARMACOLOGY, V158, P366, DOI 10.1007/s002130100701
   Ito R, 2004, NAT NEUROSCI, V7, P389, DOI 10.1038/nn1217
   Kalinichev M, 2002, NEUROPSYCHOPHARMACOL, V27, P518
   KALIVAS PW, 1993, BEHAV PHARMACOL, V4, P315
   KAPLAN HB, 1986, J HEALTH SOC BEHAV, V27, P44, DOI 10.2307/2136502
   Keeney A, 2006, J NEUROENDOCRINOL, V18, P330, DOI 10.1111/j.1365-2826.2006.01422.x
   Keeney AJ, 1999, BEHAV PHARMACOL, V10, P753, DOI 10.1097/00008877-199912000-00007
   KENDLER KS, 1995, AM J PSYCHIAT, V152, P833
   Kessler RC, 1996, AM J ORTHOPSYCHIAT, V66, P17, DOI 10.1037/h0080151
   KESSLER RC, 1985, ANNU REV PSYCHOL, V36, P531, DOI 10.1146/annurev.ps.36.020185.002531
   KIROUAC GJ, 1995, NEUROSCIENCE, V67, P625, DOI 10.1016/0306-4522(95)00013-9
   Koob G.F., 1992, SEMIN NEUROSCI, V4, P139, DOI 10.1016/1044-5765(92)90012-Q
   Koob GF, 2001, NEUROPSYCHOPHARMACOL, V24, P97, DOI 10.1016/S0893-133X(00)00195-0
   Koob GF, 1997, SCIENCE, V278, P52, DOI 10.1126/science.278.5335.52
   Koob GF, 1998, NEURON, V21, P467, DOI 10.1016/S0896-6273(00)80557-7
   Koob GF, 1999, BIOL PSYCHIAT, V46, P1167, DOI 10.1016/S0006-3223(99)00164-X
   Koolhaas JM, 1997, NEUROSCI BIOBEHAV R, V21, P775, DOI 10.1016/S0149-7634(96)00057-7
   Korte SM, 2005, NEUROSCI BIOBEHAV R, V29, P3, DOI 10.1016/j.neubiorev.2004.08.009
   Kosten TA, 2000, BRAIN RES, V875, P44, DOI 10.1016/S0006-8993(00)02595-6
   Koylu EO, 1997, J NEUROENDOCRINOL, V9, P823, DOI 10.1046/j.1365-2826.1997.00651.x
   Kreek MJ, 1996, NEUROCHEM RES, V21, P1469, DOI 10.1007/BF02532387
   Kreek MJ, 1998, DRUG ALCOHOL DEPEN, V51, P23, DOI 10.1016/S0376-8716(98)00064-7
   Kristensen P, 1998, NATURE, V393, P72, DOI 10.1038/29993
   Kudryavtseva N N, 2000, Neurosci Behav Physiol, V30, P293, DOI 10.1007/BF02471782
   Kumanyika SK, 1999, AM J CLIN NUTR, V70, P1
   Kuo LE, 2007, NAT MED, V13, P803, DOI 10.1038/nm1611
   Kuriyama H, 2004, NEUROSCIENCE, V124, P459, DOI 10.1016/j.neuroscience.2003.12.012
   Laitinen J, 2002, PREV MED, V34, P29, DOI 10.1006/pmed.2001.0948
   Lambert PD, 1998, SYNAPSE, V29, P293, DOI 10.1002/(SICI)1098-2396(199808)29:4<293::AID-SYN1>3.0.CO;2-0
   Laugero KD, 2001, ENDOCRINOLOGY, V142, P2796, DOI 10.1210/en.142.7.2796
   Le Merrer J, 2006, J NEUROSCI, V26, P7163, DOI 10.1523/JNEUROSCI.5345-05.2006
   Levin BE, 2002, AM J PHYSIOL-REG I, V283, pR941, DOI 10.1152/ajpregu.00245.2002
   LEVINE S, 1957, SCIENCE, V126, P405, DOI 10.1126/science.126.3270.405
   Levine S, 2002, NEUROTOX RES, V4, DOI 10.1080/10298420290030569
   Liu D, 1997, SCIENCE, V277, P1659, DOI 10.1126/science.277.5332.1659
   Livingstone DEW, 2000, ENDOCRINOLOGY, V141, P560, DOI 10.1210/en.141.2.560
   Loizzo A, 2006, PEDIATR RES, V59, P111, DOI 10.1203/01.pdr.0000190575.12965.ce
   Mantsch JR, 1999, PSYCHOPHARMACOLOGY, V142, P399, DOI 10.1007/s002130050905
   MARTIN RJ, 1978, HORM METAB RES, V10, P187, DOI 10.1055/s-0028-1093431
   Masuzaki H, 2001, SCIENCE, V294, P2166, DOI 10.1126/science.1066285
   Mattson BJ, 2005, NEUROSCIENCE, V135, P315, DOI 10.1016/j.neuroscience.2005.06.045
   Mattsson C, 2003, ENDOCRINOLOGY, V144, P2997, DOI 10.1210/en.2002-221015
   McIntosh J, 1999, DEV BRAIN RES, V113, P97, DOI 10.1016/S0165-3806(99)00005-X
   McLaren L, 2007, EPIDEMIOL REV, V29, P29, DOI 10.1093/epirev/mxm001
   Meaney MJ, 1996, DEV NEUROSCI-BASEL, V18, P49, DOI 10.1159/000111395
   Meaney MJ, 2001, ANNU REV NEUROSCI, V24, P1161, DOI 10.1146/annurev.neuro.24.1.1161
   MEANEY MJ, 1991, PSYCHONEUROENDOCRINO, V16, P85, DOI 10.1016/0306-4530(91)90072-2
   MEANEY MJ, 1989, NEUROENDOCRINOLOGY, V50, P597, DOI 10.1159/000125287
   Meerlo, 1996, Stress, V1, P21
   MEISEL RL, 1990, PHYSIOL BEHAV, V47, P815, DOI 10.1016/0031-9384(90)90002-L
   MICZEK KA, 1979, PSYCHOPHARMACOLOGY, V60, P253, DOI 10.1007/BF00426664
   Moffett MC, 2007, BIOCHEM PHARMACOL, V73, P321, DOI 10.1016/j.bcp.2006.08.003
   Moffett MC, 2006, J PHARMACOL EXP THER, V317, P1210, DOI 10.1124/jpet.106.101139
   MOGENSON GJ, 1980, PROG NEUROBIOL, V14, P69, DOI 10.1016/0301-0082(80)90018-0
   MOISAN MP, 1990, ENDOCRINOLOGY, V127, P1450, DOI 10.1210/endo-127-3-1450
   Mokdad AH, 2003, JAMA-J AM MED ASSOC, V289, P76, DOI 10.1001/jama.289.1.76
   Moles A, 2006, PSYCHONEUROENDOCRINO, V31, P623, DOI 10.1016/j.psyneuen.2006.01.004
   Morton NM, 2004, DIABETES, V53, P931, DOI 10.2337/diabetes.53.4.931
   Morton NM, 2001, J BIOL CHEM, V276, P41293, DOI 10.1074/jbc.M103676200
   Nammi S, 2007, AM J PHYSIOL-REG I, V292, pR1101, DOI 10.1152/ajpregu.00255.2006
   NEWCOMB MD, 1988, J ABNORM PSYCHOL, V97, P64, DOI 10.1037/0021-843X.97.1.64
   Nunez JF, 1996, PHYSIOL BEHAV, V60, P1355, DOI 10.1016/S0031-9384(96)00225-9
   OTTOSSON M, 1994, J CLIN ENDOCR METAB, V79, P820, DOI 10.1210/jc.79.3.820
   PACAK K, 1995, ENDOCRINOLOGY, V136, P4360, DOI 10.1210/en.136.10.4360
   Paeratakul S, 2002, INT J OBESITY, V26, P1205, DOI 10.1038/sj.ijo.0802026
   Panagiotaropoulos T, 2004, NEUROENDOCRINOLOGY, V79, P109, DOI 10.1159/000076633
   Pasquali R, 1999, INT J OBESITY, V23, P419, DOI 10.1038/sj.ijo.0800838
   Pasquali R, 2000, CLIN ENDOCRINOL, V52, P413, DOI 10.1046/j.1365-2265.2000.00871.x
   Pasquali R, 2006, ANN NY ACAD SCI, V1083, P111, DOI 10.1196/annals.1367.009
   Pecoraro N, 2004, ENDOCRINOLOGY, V145, P3754, DOI 10.1210/en.2004-0305
   Penke Z, 2001, EUR J NEUROSCI, V14, P747, DOI 10.1046/j.0953-816x.2001.01691.x
   Phillips PEM, 2003, NATURE, V422, P614, DOI 10.1038/nature01476
   PHILLIPSON OT, 1979, J COMP NEUROL, V187, P117, DOI 10.1002/cne.901870108
   PIAZZA PV, 1990, BRAIN RES, V514, P22, DOI 10.1016/0006-8993(90)90431-A
   Piazza PV, 1996, ANNU REV PHARMACOL, V36, P359, DOI 10.1146/annurev.pa.36.040196.002043
   Ploj K, 2003, NEUROSCIENCE, V121, P787, DOI 10.1016/S0306-4522(03)00499-8
   PLOTSKY PM, 1993, MOL BRAIN RES, V18, P195, DOI 10.1016/0169-328X(93)90189-V
   Pryce CR, 2003, NEUROSCI BIOBEHAV R, V27, P57, DOI 10.1016/S0149-7634(03)00009-5
   RAAB A, 1986, PHYSIOL BEHAV, V36, P223, DOI 10.1016/0031-9384(86)90007-7
   Rabin B.S., 1999, STRESS IMMUNE FUNCTI
   REBUFFESCRIVE M, 1985, EUR J CLIN INVEST, V15, P267, DOI 10.1111/j.1365-2362.1985.tb00182.x
   Richard D, 2000, INT J OBESITY, V24, pS36, DOI 10.1038/sj.ijo.0801275
   Rohde P, 2001, J AFFECT DISORDERS, V65, P221, DOI 10.1016/S0165-0327(00)00219-6
   Rohner-Jeanrenaud F, 2002, INT J OBESITY, V26, P143, DOI 10.1038/sj.ijo.0801863
   Roitman MF, 2004, J NEUROSCI, V24, P1265, DOI 10.1523/JNEUROSCI.3823-03.2004
   Roman E, 2006, HORM BEHAV, V50, P736, DOI 10.1016/j.yhbeh.2006.06.016
   Rosmond R, 2000, OBES RES, V8, P445, DOI 10.1038/oby.2000.55
   Ruis MAW, 1999, PSYCHONEUROENDOCRINO, V24, P285, DOI 10.1016/S0306-4530(98)00050-X
   Sahu A, 2002, J NEUROENDOCRINOL, V14, P796, DOI 10.1046/j.1365-2826.2002.00840.x
   Samra JS, 1998, J CLIN ENDOCR METAB, V83, P626, DOI 10.1210/jc.83.2.626
   SAPOLSKY R M, 1992, P287
   Sapolsky RM, 2000, ENDOCR REV, V21, P55, DOI 10.1210/er.21.1.55
   Sapolsky RM., 1992, STRESS AGING BRAIN M
   Schmidt M, 2002, DEV BRAIN RES, V139, P39, DOI 10.1016/S0165-3806(02)00519-9
   Schmidt MV, 2006, J NEUROENDOCRINOL, V18, P865, DOI 10.1111/j.1365-2826.2006.01482.x
   Schultz W, 2000, NAT REV NEUROSCI, V1, P199, DOI 10.1038/35044563
   SCHULTZ W, 1992, J NEUROSCI, V12, P4595, DOI 10.1523/jneurosci.12-12-04595.1992
   Seckl JR, 2001, ENDOCRINOLOGY, V142, P1371, DOI 10.1210/en.142.4.1371
   SELYE H, 1973, AM SCI, V61, P692
   Sgoifo A, 1999, NEUROSCI BIOBEHAV R, V23, P915, DOI 10.1016/S0149-7634(99)00025-1
   Shalev U, 2006, PSYCHOPHARMACOLOGY, V187, P376, DOI 10.1007/s00213-006-0427-y
   Silveira PP, 2006, BEHAV BRAIN RES, V173, P205, DOI 10.1016/j.bbr.2006.06.031
   Silveira PP, 2004, PHYSIOL BEHAV, V80, P739, DOI 10.1016/j.physbeh.2003.12.009
   SLAVIN BG, 1994, J LIPID RES, V35, P1535
   SMITHROE SL, 2003, J NEUROSCI, V20, P7737
   Solano JM, 1999, AM J PHYSIOL-ENDOC M, V277, pE708, DOI 10.1152/ajpendo.1999.277.4.E708
   Solomon MB, 2007, AM J PHYSIOL-REG I, V292, pR283, DOI 10.1152/ajpregu.00330.2006
   SPIESS J, 1981, BIOCHEMISTRY-US, V20, P1982, DOI 10.1021/bi00510a038
   STRACK AM, 1995, AM J PHYSIOL-REG I, V268, pR142, DOI 10.1152/ajpregu.1995.268.1.R142
   Strack AM, 1997, AM J PHYSIOL-REG I, V272, pR840, DOI 10.1152/ajpregu.1997.272.3.R840
   Stratford TR, 1999, J NEUROSCI, V19, P11040, DOI 10.1523/JNEUROSCI.19-24-11040.1999
   Tamashiro KLK, 2006, PHYSIOL BEHAV, V89, P536, DOI 10.1016/j.physbeh.2006.05.026
   Tamashiro KLK, 2004, PHYSIOL BEHAV, V80, P683, DOI 10.1016/j.physbeh.2003.12.002
   Teegarden SL, 2007, BIOL PSYCHIAT, V61, P1021, DOI 10.1016/j.biopsych.2006.09.032
   Tidey JW, 1997, PSYCHOPHARMACOLOGY, V130, P203, DOI 10.1007/s002130050230
   Tomlinson JW, 2001, ENDOCRINOLOGY, V142, P1982, DOI 10.1210/en.142.5.1982
   TOMLINSON JW, 2001, ENDOCRINOLOGICAL REV, V25, P831
   Troisi A, 2001, PHYSIOL BEHAV, V73, P443, DOI 10.1016/S0031-9384(01)00459-0
   Uddén J, 2003, J INTERN MED, V253, P225, DOI 10.1046/j.1365-2796.2003.01099.x
   Uysal KT, 1998, ENDOCRINOLOGY, V139, P4832, DOI 10.1210/en.139.12.4832
   Vallee M, 1996, BRAIN RES, V712, P287, DOI 10.1016/0006-8993(95)01459-4
   VANSTRIEN T, 1986, INT J OBESITY, V10, P29
   Vazquez V, 2006, BEHAV BRAIN RES, V170, P211, DOI 10.1016/j.bbr.2006.02.022
   Vogelzangs N, 2007, PSYCHONEUROENDOCRINO, V32, P151, DOI 10.1016/j.psyneuen.2006.11.009
   Volkow ND, 2007, AM J PSYCHIAT, V164, P708, DOI 10.1176/appi.ajp.164.5.708
   Von Frijtag JC, 2000, BEHAV BRAIN RES, V117, P137, DOI 10.1016/S0166-4328(00)00300-4
   Vrang N, 2003, BRAIN RES, V965, P45, DOI 10.1016/S0006-8993(02)04064-7
   Vrang N, 2000, ENDOCRINOLOGY, V141, P794, DOI 10.1210/en.141.2.794
   Vrang N, 2002, NEUROREPORT, V13, P1215, DOI 10.1097/00001756-200207020-00029
   WALKER BR, 1995, J CLIN ENDOCR METAB, V80, P3155, DOI 10.1210/jc.80.11.3155
   WALKER CD, 1992, ENDOCRINOLOGY, V131, P2629, DOI 10.1210/en.131.6.2629
   Wan SL, 2005, NEUROSCI LETT, V382, P96, DOI 10.1016/j.neulet.2005.02.066
   Weinstock M, 1997, NEUROSCI BIOBEHAV R, V21, P1, DOI 10.1016/S0149-7634(96)00014-0
   Widom CS, 1999, J CONSULT CLIN PSYCH, V67, P867, DOI 10.1037/0022-006X.67.6.867
   Wierup N, 2004, J HISTOCHEM CYTOCHEM, V52, P169, DOI 10.1177/002215540405200204
   Wierup N, 2006, DIABETES, V55, P305, DOI 10.2337/diabetes.55.02.06.db04-1383
   Wills TA, 1996, J ABNORM PSYCHOL, V105, P166, DOI 10.1037/0021-843X.105.2.166
   WISE RA, 1985, BEHAV BRAIN SCI, V8, P178, DOI 10.1017/S0140525X00020306
   WISE RA, 1981, THEORY PSYCHOPHARMAC, P102
   Wortley KE, 2004, REGUL PEPTIDES, V117, P89, DOI 10.1016/j.regpep.2003.08.005
   Zheng HY, 2002, AM J PHYSIOL-REG I, V282, pR1773, DOI 10.1152/ajpregu.00019.2002
NR 216
TC 63
Z9 73
U1 0
U2 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD APR
PY 2009
VL 33
IS 4
SI SI
BP 537
EP 550
DI 10.1016/j.neubiorev.2008.05.018
PG 14
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA 431ST
UT WOS:000265084700006
PM 18585781
DA 2025-06-11
ER

PT J
AU Fandos, M
   Corella, D
   Guillén, M
   Portolés, O
   Carrasco, P
   Iradi, A
   Martínez-González, MA
   Estruch, R
   Covas, MI
   Lamuela-Raventós, RM
   Michavilla, MT
   Cerdá, C
   Torregrosa, R
   Redón, J
   Chaves, FF
   Tormos, MC
   Ocete, D
   Sáez, GT
AF Fandos, Marta
   Corella, Dolores
   Guillen, Marisa
   Portoles, Olga
   Carrasco, Paula
   Iradi, Antonio
   Martinez-Gonzalez, Miguel A.
   Estruch, Ramon
   Covas, Maria I.
   Maria Lamuela-Raventos, Rosa
   Teresa Michavilla, Maria
   Cerda, Concha
   Torregrosa, Rafael
   Redon, Josep
   Felipe Chaves, Francisco
   Carmen Tormos, M.
   Ocete, Dolores
   Saez, Guillermo T.
CA Predimed Grp
TI Impact of cardiovascular risk factors on oxidative stress and DNA damage
   in a high risk Mediterranean population
SO FREE RADICAL RESEARCH
LA English
DT Article
DE Oxidative stress; 8-oxo-dG; cardiovascular risk factors; hypertension;
   primary prevention
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; ANTIOXIDANT ACTIVITIES;
   PLASMA-LEVELS; BY-PRODUCTS; DIET; ATHEROSCLEROSIS; GLUTATHIONE;
   EXPRESSION; RESISTANCE
AB The impact of classic cardiovascular risk factors on oxidative stress status in a high-risk cardiovascular Mediterranean population of 527 subjects was estimated. Oxidative stress markers (malondialdehyde, 8-oxo-7'8'-dihydro-2'-deoxyguanosine, oxidized/reduced glutathione ratio) together with the activity of antioxidant enzyme triad (superoxide dismutase, catalase, glutathione peroxidase) were analysed in circulating mononuclear blood cells. Malondialdehyde, oxidized glutathione and the ratio of oxidized to reduced glutathione were significantly higher while catalase and glutathione peroxidase activities were significantly lower in high cardiovascular risk participants than in controls. Statistically significant differences were obtained after additional multivariate control for sex, age, obesity, diabetes, lipids and medications. Among the main cardiovascular risk factors, hypertension was the strongest determinant of oxidative stress in high risk subjects studied at a primary prevention stage.
C1 [Fandos, Marta; Carmen Tormos, M.; Saez, Guillermo T.] Univ Valencia, Fac Med, Dept Biochem & Mol Biol, Avda Blasco Ibanez 15, Valencia, Spain.
   [Corella, Dolores; Guillen, Marisa; Portoles, Olga; Carrasco, Paula] Univ Valencia, Sch Med, Dept Prevent Med, Valencia, Spain.
   [Corella, Dolores; Estruch, Ramon; Covas, Maria I.] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid, Spain.
   [Iradi, Antonio] Univ Valencia, Fac Med, Dept Physiol, Valencia, Spain.
   [Martinez-Gonzalez, Miguel A.] Univ Navarra, Dept Prevent Med & Publ Hlth, Navarra, Spain.
   [Estruch, Ramon] Hosp Clin Barcelona, Dept Internal Med, Barcelona, Spain.
   [Covas, Maria I.] Municipal Inst Med Res IMIM, Cardiovasc Epidemiol Unit, Barcelona, Spain.
   [Maria Lamuela-Raventos, Rosa] Sch Pharm, Dept Nutr & Bromatol, Barcelona, Spain.
   [Teresa Michavilla, Maria] Univ Barcelona, Dept Physiol, Diagonal, Spain.
   [Cerda, Concha; Torregrosa, Rafael] Gen Univ Hosp, Clin Anal Serv, Patras, Greece.
   [Redon, Josep] Univ Valencia, Hypertens Unit, Serv Internal Med, Clin Univ Hosp, Valencia, Spain.
   [Felipe Chaves, Francisco] Clin Univ Hosp Valencia, Fdn Res, Valencia, Spain.
   [Ocete, Dolores] Univ Valencia, Microbiol Unit C, Valencia, Spain.
   [Saez, Guillermo T.] Univ Valencia, Gen Univ Hosp, Fac Med, Dept Biochem & Mol Biol, Valencia, Spain.
C3 University of Valencia; University of Valencia; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III;
   University of Valencia; University of Navarra; University of Barcelona;
   Hospital Clinic de Barcelona; Hospital del Mar Research Institute;
   University of Barcelona; University of Valencia; University of Valencia;
   University of Valencia
RP Sáez, GT (corresponding author), Univ Valencia, Fac Med, Dept Biochem & Mol Biol, Avda Blasco Ibanez 15, Valencia, Spain.
EM guillermo.saez@uv.es
RI Corella, Dolores/L-9888-2014; Martinez-Gonzalez, Miguel/AAE-7669-2019;
   CHAVES, FELIPE/ABC-3294-2021; Estruch, Ramon/AAZ-3723-2020; Redon,
   Josep/L-5997-2019; Marisa, Guillén/AAJ-8250-2020; Lamuela-Raventos, Rosa
   M/F-3986-2016; Carrasco, Paula/D-7864-2019
OI Lamuela-Raventos, Rosa M/0000-0002-1287-4560; Carrasco,
   Paula/0000-0002-7170-4318; CHAVES, FELIPE J/0000-0001-8009-3689; Saez,
   Guillermo/0000-0002-8164-4048; Redon, Josep/0000-0001-8777-6773;
   Martinez-Gonzalez, Miguel A./0000-0002-3917-9808; Marisa,
   Guillen/0000-0001-5802-6316
FU Instituto de Salud Carlos III [FIS PI070240, PI052368, PI051458,
   PI042234, RD06/0045/0006, CIBER06/03]; Conselleria de Sanitat Valencia
   [GRUPOS 03/101, GRUPOS2004-43, ACOMP06109]
FX Sources of Funding: Instituto de Salud Carlos III (FIS PI070240,
   PI052368, PI051458, PI042234, RD06/0045/0006 and CIBER06/03);
   Conselleria de Sanitat Valencia (GRUPOS 03/101, GRUPOS2004-43 and
   ACOMP06109).
CR Abdilla N, 2007, J HUM HYPERTENS, V21, P68, DOI 10.1038/sj.jhh.1002105
   Andreassi MG, 2003, TRENDS CARDIOVAS MED, V13, P270, DOI 10.1016/S1050-1738(03)00109-9
   [Anonymous], N ENGL J MED
   ARDER DJ, 2008, NATURE, V451, P904
   ASENSI M, 1994, ANAL BIOCHEM, V217, P323, DOI 10.1006/abio.1994.1126
   Ashfaq S, 2006, J AM COLL CARDIOL, V47, P1005, DOI 10.1016/j.jacc.2005.09.063
   Bennett MR, 2001, CIRC RES, V88, P648, DOI 10.1161/hh0701.089955
   Blankenberg S, 2003, NEW ENGL J MED, V349, P1605, DOI 10.1056/NEJMoa030535
   Borrás C, 2006, FASEB J, V20, P2136, DOI 10.1096/fj.05-5522fje
   BOYUM A, 1968, SCAND J CLIN LAB INV, VS 21, P77
   Chaves FJ, 2007, AM J HYPERTENS, V20, P62, DOI 10.1016/j.amjhyper.2006.06.006
   CHENG KC, 1992, J BIOL CHEM, V267, P166
   Cooke MS, 2000, FREE RADICAL RES, V32, P381, DOI 10.1080/10715760000300391
   Dalle-Donne I, 2006, CLIN CHEM, V52, P601, DOI 10.1373/clinchem.2005.061408
   Espinosa O, 2007, FREE RADICAL RES, V41, P546, DOI 10.1080/10715760601164050
   Estruch R, 2006, ANN INTERN MED, V145, P1, DOI 10.7326/0003-4819-145-1-200607040-00004
   FRENKEL K, 1991, ANAL BIOCHEM, V196, P126, DOI 10.1016/0003-2697(91)90128-G
   Fung TT, 2009, CIRCULATION, V119, P1093, DOI 10.1161/CIRCULATIONAHA.108.816736
   GALIS ZS, 1994, J CLIN INVEST, V94, P2493, DOI 10.1172/JCI117619
   Gedik CM, 2005, FASEB J, V19, P82, DOI 10.1096/fj.04-1767fje
   Greenland P, 2003, JAMA-J AM MED ASSOC, V290, P891, DOI 10.1001/jama.290.7.891
   Greenwald R.A., 1987, HDB METHODS OXYGEN R
   Holvoet P, 2004, DIABETES, V53, P1068, DOI 10.2337/diabetes.53.4.1068
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   Konhilas JP, 2007, CIRCULATION, V116, P2747, DOI 10.1161/CIRCULATIONAHA.106.672006
   Kris-Etherton PM, 1999, CIRCULATION, V100, P1253, DOI 10.1161/01.CIR.100.11.1253
   Mansego ML, 2007, ANTIOXID REDOX SIGN, V9, P507, DOI 10.1089/ars.2006.1472
   Martínez-González MA, 2004, EUR J CLIN NUTR, V58, P1550, DOI 10.1038/sj.ejcn.1602004
   Mercer J, 2006, CELL CYCLE, V5, P1907, DOI 10.4161/cc.5.17.3166
   MUNIZ P, 1995, FREE RADICAL BIO MED, V18, P747, DOI 10.1016/0891-5849(94)00200-4
   MURRAY CJL, 1999, GLOBAL BURDEN DIS CO
   Polidori MC, 2003, BRIT J NUTR, V90, P147, DOI 10.1079/BJN2003890
   Rahman I, 1999, FREE RADICAL BIO MED, V27, P60, DOI 10.1016/S0891-5849(99)00035-0
   Raij L, 1998, HYPERTENSION, V31, P189, DOI 10.1161/01.HYP.31.1.189
   Redón J, 2003, HYPERTENSION, V41, P1096, DOI 10.1161/01.HYP.0000068370.21009.38
   Romero JC, 1999, HYPERTENSION, V34, P943, DOI 10.1161/01.HYP.34.4.943
   ROSS R, 1993, NATURE, V362, P801, DOI 10.1038/362801a0
   Sáez GT, 2004, AM J HYPERTENS, V17, P809, DOI 10.1016/j.amjhyper.2004.05.022
   Sutherland WHF, 2007, OBESITY, V15, P386, DOI 10.1038/oby.2007.546
   Tsimikas S, 2005, NEW ENGL J MED, V353, P46, DOI 10.1056/NEJMoa043175
   Ungvari Z, 2008, CIRC RES, V102, P519, DOI 10.1161/CIRCRESAHA.107.168369
   Urakawa H, 2003, J CLIN ENDOCR METAB, V88, P4673, DOI 10.1210/jc.2003-030202
   Weinbrenner T, 2004, J NUTR, V134, P2314, DOI 10.1093/jn/134.9.2314
   WONG SHY, 1987, CLIN CHEM, V33, P214
NR 44
TC 16
Z9 16
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PY 2009
VL 43
IS 12
BP 1179
EP 1186
DI 10.3109/10715760903247231
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 532MP
UT WOS:000272753100004
PM 19905980
DA 2025-06-11
ER

PT J
AU Chen, R
   Qi, QL
   Wang, MT
   Li, QY
AF Chen, Rui
   Qi, Qiao-Ling
   Wang, Meng-Ting
   Li, Qi-Yan
TI Therapeutic potential of naringin: an overview
SO PHARMACEUTICAL BIOLOGY
LA English
DT Article
DE Pharmacological action; bone regeneration; anti-inflammatory;
   anti-cancer; extraction technology; controlled release formulations
ID MITOCHONDRIA-MEDIATED APOPTOSIS; NF-KAPPA-B; OXIDATIVE STRESS;
   TOXICOLOGICAL EVALUATION; INDUCED OSTEOPOROSIS; METABOLIC SYNDROME;
   CITRUS FLAVONOIDS; FRUCTUS AURANTII; BONE-RESORPTION; RAT PLASMA
AB Context: Naringin is a natural flavanone glycoside that is found in the Chinese herbal medicines and citrus fruits. Studies have demonstrated that naringin possesses numerous biological and pharmacological properties, but few reviews of these studies have been performed.
   Objective: The present review gathers the fragmented information available in the literature describing the extraction of naringin, its pharmacology and its controlled release formulations. Current research progress and the therapeutic potential of naringin are also discussed.
   Methods: A literature survey for relevant information regarding the biological and pharmacological properties of naringin was conducted using Pubmed, Sciencedirect, MEDLINE, Springerlink and Google Scholar electronic databases from the year 2007-2015.
   Results: Naringin modulates signalling pathways and interacts with signalling molecules and thus has a wide range of pharmacological activities, including anti-inflammatory, anti-cancer activities, as well as effects on bone regeneration, metabolic syndrome, oxidative stress, genetic damage and central nervous system (CNS) diseases. Information was gathered that showed the extraction of naringin can be improved using several modifications. There has been some progress in the development of controlled release formulations of naringin.
   Conclusion: Naringin is a promising candidate for further in vivo studies and clinical use. More detailed studies regarding its mechanism of action are required.
C1 [Chen, Rui; Wang, Meng-Ting; Li, Qi-Yan] Kunming Univ Sci & Technol, Fac Med, Kunming, Yunnan, Peoples R China.
   [Chen, Rui; Wang, Meng-Ting; Li, Qi-Yan] First Peoples Hosp Yunnan Prov, Kunming 650032, Yunnan, Peoples R China.
   [Chen, Rui; Wang, Meng-Ting; Li, Qi-Yan] Univ Sci & Technol Kunming, Affiliated Hosp Ctr, Kunming, Yunnan, Peoples R China.
   [Qi, Qiao-Ling] Dali Univ, Yunnan Prov Key Lab Entomol Biopharmaceut R, Dali, Yunnan, Peoples R China.
C3 Kunming University of Science & Technology; Kunming University of
   Science & Technology; Dali University
RP Li, QY (corresponding author), Kunming Univ Sci & Technol, Fac Med, Kunming, Yunnan, Peoples R China.; Li, QY (corresponding author), First Peoples Hosp Yunnan Prov, Kunming 650032, Yunnan, Peoples R China.; Li, QY (corresponding author), Univ Sci & Technol Kunming, Affiliated Hosp Ctr, Kunming, Yunnan, Peoples R China.
EM ynliqiyan@aliyun.com
FU National Scientific Foundation of China under the National Scientific
   Grant [81160134]; Yunnan Provincial Science and Technology Department
   under the Grant Talent Reserve of Young Academic and Technical Leaders
   of Yunnan Province [2012HB027]; Yunnan Provincial Bureau of Health under
   the Grant Medical Academic Leaders of Yunnan Province [D-201232]
FX This work was supported by the National Scientific Foundation of China
   under the National Scientific Grant [grant number 81160134]; by the
   Yunnan Provincial Science and Technology Department under the Grant
   Talent Reserve of Young Academic and Technical Leaders of Yunnan
   Province [grant number 2012HB027]; and by the Yunnan Provincial Bureau
   of Health under the Grant Medical Academic Leaders of Yunnan Province
   [grant number D-201232].
CR Alam MA, 2014, ADV NUTR, V5, P404, DOI 10.3945/an.113.005603
   Alam MA, 2013, NUTRIENTS, V5, P637, DOI 10.3390/nu5030637
   Ang ESM, 2011, FEBS LETT, V585, P2755, DOI 10.1016/j.febslet.2011.07.046
   Attia SM, 2008, MUTAGENESIS, V23, P515, DOI 10.1093/mutage/gen045
   Bacanli M, 2015, FOOD CHEM TOXICOL, V81, P160, DOI 10.1016/j.fct.2015.04.015
   Bakheet S, 2011, OXID MED CELL LONGEV, V2011, DOI 10.1155/2011/365292
   Baskaran G, 2015, DRUG DES DEV THER, V9, P509, DOI 10.2147/DDDT.S75056
   Benavente-García O, 2008, J AGR FOOD CHEM, V56, P6185, DOI 10.1021/jf8006568
   Bharti S, 2014, PLANTA MED, V80, P437, DOI 10.1055/s-0034-1368351
   Chen FQ, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0143868
   Chen J.C., 2011, CHIN J INTEGR MED, DOI [10.1007/s11655-011-0882-0, DOI 10.1007/S11655-011-0882-0]
   Chen KY, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/283941
   Chen LL, 2011, ARCH ORAL BIOL, V56, P1655, DOI 10.1016/j.archoralbio.2011.06.008
   Chtourou Y, 2015, J MOL NEUROSCI, V56, P349, DOI 10.1007/s12031-015-0547-0
   Cordenonsi LM, 2016, BIOMED CHROMATOGR, V30, P155, DOI 10.1002/bmc.3531
   Dhanya R, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0132429
   Ferrero-Miliani L, 2007, CLIN EXP IMMUNOL, V147, P227, DOI 10.1111/j.1365-2249.2006.03261.x
   Ghasemzadeh A, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-341
   Golechha M, 2014, EPILEPSY BEHAV, V41, P98, DOI 10.1016/j.yebeh.2014.09.058
   Gopinath K, 2012, NEUROSCIENCE, V227, P134, DOI 10.1016/j.neuroscience.2012.07.060
   Habauzit V, 2011, BONE, V49, P1108, DOI 10.1016/j.bone.2011.07.030
   Jäger AK, 2011, MOLECULES, V16, P1471, DOI 10.3390/molecules16021471
   Jeong KH, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/354326
   Ji Y, 2014, DENT MATER, V30, P1263, DOI 10.1016/j.dental.2014.08.381
   Jin YR, 2015, J CHROMATOGR B, V1000, P112, DOI 10.1016/j.jchromb.2015.06.027
   Johnson MK, 2000, MUTAT RES-DNA REPAIR, V459, P211, DOI 10.1016/S0921-8777(99)00074-9
   Jung UJ, 2014, NEURAL REGEN RES, V9, P1514, DOI 10.4103/1673-5374.139476
   Kim DI, 2008, CARCINOGENESIS, V29, P1701, DOI 10.1093/carcin/bgn055
   Kim YH, 2015, ADV DRUG DELIVER REV, V94, P28, DOI 10.1016/j.addr.2015.06.003
   Kumar A, 2010, FOOD CHEM TOXICOL, V48, P626, DOI 10.1016/j.fct.2009.11.043
   Kumar VS, 2014, J BIOMED RES, V28, P132, DOI 10.7555/JBR.27.20120082
   Lewinska A, 2015, TOXICOL IN VITRO, V29, P417, DOI 10.1016/j.tiv.2014.12.005
   Li FB, 2014, BIOCHEM BIOPH RES CO, V452, P629, DOI 10.1016/j.bbrc.2014.08.117
   Li HZ, 2013, TOXICOL LETT, V220, P219, DOI 10.1016/j.toxlet.2013.05.006
   Li NH, 2014, DRUG DES DEV THER, V8, P1, DOI 10.2147/DDDT.S52714
   Li NH, 2013, J ORTHOP SCI, V18, P478, DOI 10.1007/s00776-013-0362-9
   Li PB, 2014, FOOD CHEM TOXICOL, V66, P65, DOI 10.1016/j.fct.2014.01.023
   Li PB, 2013, FOOD CHEM TOXICOL, V60, P1, DOI 10.1016/j.fct.2013.07.019
   Li SG, 2015, BIOMED ENVIRON SCI, V28, P272, DOI 10.3967/bes2015.038
   Li SQ, 2013, METABOLITES, V3, P867, DOI 10.3390/metabo3040867
   Liu Y, 2011, INT IMMUNOPHARMACOL, V11, P1606, DOI 10.1016/j.intimp.2011.05.022
   Lu YJ, 2015, J CHROMATOGR B, V993, P75, DOI 10.1016/j.jchromb.2015.04.021
   Luo YL, 2012, INT IMMUNOPHARMACOL, V13, P301, DOI 10.1016/j.intimp.2012.04.019
   Mahmoud AM, 2012, J DIABETES COMPLICAT, V26, P483, DOI 10.1016/j.jdiacomp.2012.06.001
   Manthey JA, 2001, CURR MED CHEM, V8, P135, DOI 10.2174/0929867013373723
   Pang WY, 2010, BRIT J PHARMACOL, V159, P1693, DOI 10.1111/j.1476-5381.2010.00664.x
   Peng-Zhang, 2009, EUR J PHARMACOL, V607, P1, DOI 10.1016/j.ejphar.2009.01.035
   Pereira RMS, 2007, MOLECULES, V12, P1352, DOI 10.3390/12071352
   Pu P, 2012, ARCH BIOCHEM BIOPHYS, V518, P61, DOI 10.1016/j.abb.2011.11.026
   Rajadurai M, 2007, TOXICOLOGY, V232, P216, DOI 10.1016/j.tox.2007.01.006
   Ramesh E, 2013, FOOD CHEM TOXICOL, V51, P97, DOI 10.1016/j.fct.2012.07.033
   Sachdeva AK, 2014, PHARMACOL BIOCHEM BE, V127, P101, DOI 10.1016/j.pbb.2014.11.002
   Sudto K, 2009, INT J FOOD SCI TECH, V44, P1737, DOI 10.1111/j.1365-2621.2009.01989.x
   Surampalli G, 2015, DRUG DEV IND PHARM, V41, P1057, DOI 10.3109/03639045.2014.925918
   Tan TW, 2014, INT IMMUNOPHARMACOL, V22, P107, DOI 10.1016/j.intimp.2014.06.029
   Tsai YJ, 2012, J AGR FOOD CHEM, V60, P12435, DOI 10.1021/jf301962g
   Wang C, 2010, BIOMED CHROMATOGR, V24, P235, DOI 10.1002/bmc.1278
   Wang DM, 2013, INT J MOL SCI, V14, P5576, DOI 10.3390/ijms14035576
   Wang DM, 2015, CELL MOL NEUROBIOL, V35, P1061, DOI 10.1007/s10571-015-0201-y
   Wang SS, 2011, PHARM BIOL, V49, P810, DOI 10.3109/13880209.2010.550054
   Wei M, 2007, AM J CHINESE MED, V35, P663, DOI 10.1142/S0192415X07005156
   Wong KC, 2013, BRIT J NUTR, V110, P475, DOI 10.1017/S0007114512005405
   Wu JB, 2008, EUR J PHARMACOL, V588, P333, DOI 10.1016/j.ejphar.2008.04.030
   Yin Fang-ming, 2015, Zhongguo Gu Shang, V28, P182
   Yin LH, 2015, STEM CELLS INT, V2015, DOI 10.1155/2015/758706
   Yoon HY, 2012, BIOMOL THER, V20, P89, DOI 10.4062/biomolther.2012.20.1.089
   Zhang JZ, 2014, IRAN J PHARM RES, V13, P493
   Zhao BT, 2015, ARCH PHARM RES, V38, P1512, DOI 10.1007/s12272-015-0583-x
   Zhao P, 2015, FOOD CHEM, V173, P54, DOI 10.1016/j.foodchem.2014.10.010
NR 69
TC 285
Z9 306
U1 14
U2 162
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1388-0209
EI 1744-5116
J9 PHARM BIOL
JI Pharm. Biol.
PD DEC
PY 2016
VL 54
IS 12
BP 3203
EP 3210
DI 10.1080/13880209.2016.1216131
PG 8
WC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
GA EE2VN
UT WOS:000389443300053
PM 27564838
OA Bronze
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Lubrano, C
   Valacchi, G
   Specchia, P
   Gnessi, L
   Rubanenko, EP
   Shuginina, EA
   Trukhanov, AI
   Korkina, LG
   De Luca, C
AF Lubrano, Carla
   Valacchi, Giuseppe
   Specchia, Palma
   Gnessi, Lucio
   Rubanenko, Elizaveta P.
   Shuginina, Elena A.
   Trukhanov, Arseny I.
   Korkina, Liudmila G.
   De Luca, Chiara
TI Integrated Haematological Profiles of Redox Status, Lipid, and
   Inflammatory Protein Biomarkers in Benign Obesity and Unhealthy Obesity
   with Metabolic Syndrome
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID LOW-GRADE INFLAMMATION; ADIPOSE-TISSUE EXPRESSION;
   NECROSIS-FACTOR-ALPHA; FATTY LIVER-DISEASE; OXIDATIVE STRESS; VITAMIN-E;
   SIGNALING PATHWAYS; LINKING OBESITY; WEIGHT-LOSS; GLUTATHIONE
AB The pathogenesis of obesity (OB) and metabolic syndrome (MetS) implies free radical-, oxidized lipid- (LOOH-), and inflammatory cytokine-mediated altered pathways in target organs. Key elements of the transition from benign OB to unhealthy OB+MetS remain unclear. Here, we measured a panel of redox, antioxidant, and inflammation markers in the groups of OB patients (67 with, 45 without MetS) and 90 controls. Both OB groups displayed elevated levels of adipokines and heavy oxidative stress (OS) evidenced by reduced levels of glutathione, downregulated glutathione-S-transferase, increased 4-hydroxynonenal-protein adducts, reactive oxygen species, and membrane-bound monounsaturated fatty acids (MUFA). Exclusively in OB+MetS, higher-than-normal glutathione peroxidase activity, tumor necrosis factor-alpha, and other proinflammatory cytokines/chemokines/growth factors were observed; a combination of high adipokine plasminogen activator inhibitor-1 and MUFA was consistent with increased cardiovascular risk. The uncomplicated OB group showed features of adaptation to OS such as decreased levels of vitamin E, activated superoxide dismutase, and inhibited catalase, suggesting H2O2 hyperproduction. Proinflammatory cytokine pattern was normal, except few markers like RANTES, a suitable candidate for therapeutic approaches to prevent a setting of MetS by inhibition of LOOH-primed leukocyte chemotaxis/recruitment to target tissues.
C1 [Lubrano, Carla; Specchia, Palma; Gnessi, Lucio] Univ Roma La Sapienza, Policlin Umberto 1, Dept Expt Med, Sect Med Pathophysiol Endocrinol & Food Sci, I-00161 Rome, Italy.
   [Valacchi, Giuseppe] Univ Ferrara, Dept Life Sci & Biotechnol, I-44100 Ferrara, Italy.
   [Valacchi, Giuseppe] Kyung Hee Univ, Dept Food & Nutr, Seoul 130701, South Korea.
   [Rubanenko, Elizaveta P.; Shuginina, Elena A.; Trukhanov, Arseny I.; Korkina, Liudmila G.] Act Longev Clin, Inst Krasoty Arbate, Moscow 119002, Russia.
   [Korkina, Liudmila G.; De Luca, Chiara] Cibi NanoLab, Ctr Innovat Biotechnol Invest, Moscow 119571, Russia.
C3 Sapienza University Rome; University Hospital Sapienza Rome; University
   of Ferrara; Kyung Hee University
RP De Luca, C (corresponding author), Cibi NanoLab, Ctr Innovat Biotechnol Invest, 197 Vernadskogo Prospekt, Moscow 119571, Russia.
EM deluca@cibi-nanolab.com
RI Gnessi, Lucio/K-8025-2016; Shuginina, Elena/AAH-6995-2019; Trukhanov,
   Arseniy/AAV-6037-2020
OI Gnessi, Lucio/0000-0001-8217-2372
CR Abete I, 2011, NUTR METAB CARDIOVAS, V21, pB1, DOI 10.1016/j.numecd.2011.05.001
   Adamczak M, 2013, SEMIN NEPHROL, V33, P2, DOI 10.1016/j.semnephrol.2012.12.008
   Aebi H, 1984, Methods Enzymol, V105, P121
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   ALIN P, 1985, FEBS LETT, V179, P267, DOI 10.1016/0014-5793(85)80532-9
   [Anonymous], 1999, DEFINITION DIAGNOSIS
   Ballatori N, 2009, BIOL CHEM, V390, P191, DOI 10.1515/BC.2009.033
   Blüher M, 2012, DIABETES CARE, V35, P342, DOI 10.2337/dc11-1267
   Blühre M, 2009, EXP CLIN ENDOCR DIAB, V117, P241, DOI 10.1055/s-0029-1192044
   Bochkov VN, 2010, ANTIOXID REDOX SIGN, V12, P1009, DOI 10.1089/ars.2009.2597
   Bosy-Westphal A, 2006, INT J OBESITY, V30, P475, DOI 10.1038/sj.ijo.0803144
   Brown GE, 1999, J TRAUMA, V46, P297, DOI 10.1097/00005373-199902000-00017
   Calder PC, 2011, BRIT J NUTR, V106, pS1, DOI 10.1017/S0007114511005460
   Cao JJ, 2011, J ORTHOP SURG RES, V6, DOI 10.1186/1749-799X-6-30
   Castellani ML, 2007, INT J IMMUNOPATH PH, V20, P447, DOI 10.1177/039463200702000303
   Chakaroun R, 2012, METABOLISM, V61, P706, DOI 10.1016/j.metabol.2011.10.008
   Chu SH, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034710
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Codreanu SG, 2009, MOL CELL PROTEOMICS, V8, P670, DOI 10.1074/mcp.M800070-MCP200
   Cohen G, 2013, FREE RADICAL BIO MED, V65, P978, DOI 10.1016/j.freeradbiomed.2013.08.163
   Conti P, 2001, ALLERGY ASTHMA PROC, V22, P133, DOI 10.2500/108854101778148737
   Curtis JM, 2010, DIABETES, V59, P1132, DOI 10.2337/db09-1105
   De Luca C, 1999, FREE RADICAL RES, V30, P453, DOI 10.1080/10715769900300491
   De Luca C, 2009, TOXICOL IND HEALTH, V25, P259, DOI 10.1177/0748233709103032
   Deeva I, 2010, CYTOKINE, V49, P163, DOI 10.1016/j.cyto.2009.09.014
   Donini Lorenzo Maria, 2013, Int J Endocrinol, V2013, P285680, DOI 10.1155/2013/285680
   Flohé L, 2008, ANTIOXID REDOX SIGN, V10, P1485, DOI 10.1089/ars.2008.2059
   Freeman LR, 2013, FREE RADICAL BIO MED, V56, P226, DOI 10.1016/j.freeradbiomed.2012.08.577
   Galic S, 2010, MOL CELL ENDOCRINOL, V316, P129, DOI 10.1016/j.mce.2009.08.018
   Giovannoni G, 1997, ANN CLIN BIOCHEM, V34, P193, DOI 10.1177/000456329703400212
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   HABIG WH, 1974, J BIOL CHEM, V249, P7130
   Hajjar DP, 2013, AM J PATHOL, V182, P1474, DOI 10.1016/j.ajpath.2013.01.010
   Halliwell Barry, 1993, American Journal of Clinical Nutrition, V57, p715S, DOI 10.1093/ajcn/57.5.715S
   Hayes JD, 2005, ANNU REV PHARMACOL, V45, P51, DOI 10.1146/annurev.pharmtox.45.120403.095857
   He CT, 2014, INT J ENDOCRINOL, V2014, DOI 10.1155/2014/657607
   Heilbronn LK, 2008, CURR PHARM DESIGN, V14, P1225, DOI 10.2174/138161208784246153
   Hopps E, 2013, CLIN INVEST MED, V36, pE1
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   HOTAMISLIGIL GS, 1995, J CLIN INVEST, V95, P2409, DOI 10.1172/JCI117936
   Hotta K, 2000, ARTERIOSCL THROM VAS, V20, P1595, DOI 10.1161/01.ATV.20.6.1595
   James WPT, 2008, INT J OBESITY, V32, pS120, DOI 10.1038/ijo.2008.247
   Kantartzis K, 2010, DIGEST DIS, V28, P169, DOI 10.1159/000282082
   Karagozian R, 2014, METABOLISM, V63, P607, DOI 10.1016/j.metabol.2014.01.011
   KEYS A, 1972, J CHRON DIS, V25, P329, DOI 10.1016/0021-9681(72)90027-6
   Kogiso T, 2009, J GASTROENTEROL, V44, P313, DOI 10.1007/s00535-009-0002-5
   Korkina L, 2010, DRUG TODAY, V46, P119, DOI 10.1358/dot.2010.46.2.1452078
   KORKINA LG, 1992, J LEUKOCYTE BIOL, V52, P357, DOI 10.1002/jlb.52.3.357
   Kostyuk VA, 2010, ANTIOXID REDOX SIGN, V13, P607, DOI 10.1089/ars.2009.2976
   Lehr S, 2012, PROTEOM CLIN APPL, V6, P91, DOI 10.1002/prca.201100052
   Liu TF, 2012, J LEUKOCYTE BIOL, V92, P499, DOI 10.1189/jlb.0212078
   Lubrano C, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/640673
   Masoodi M, 2015, BBA-MOL CELL BIOL L, V1851, P503, DOI 10.1016/j.bbalip.2014.09.023
   Matsuda M, 2013, OBES RES CLIN PRACT, V7, pE330, DOI 10.1016/j.orcp.2013.05.004
   Matsuzawa Y, 2011, J ATHEROSCLER THROMB, V18, P629, DOI 10.5551/jat.7922
   Mattson MP, 2009, EXP GERONTOL, V44, P625, DOI 10.1016/j.exger.2009.07.003
   Mazor R, 2008, ATHEROSCLEROSIS, V197, P937, DOI 10.1016/j.atherosclerosis.2007.08.014
   Mierzynski R, 2014, CURR PHARM BIOTECHNO, V15, P47, DOI 10.2174/1389201015666140330194049
   Miller Nicholas J., 1993, Biochemical Society Transactions, V21, p95S
   Mittendorfer B, 2011, CURR OPIN CLIN NUTR, V14, P535, DOI 10.1097/MCO.0b013e32834ad8b6
   Murdolo G, 2013, BIOCHIMIE, V95, P585, DOI 10.1016/j.biochi.2012.12.014
   Niki E, 2014, FREE RADICAL BIO MED, V66, P3, DOI 10.1016/j.freeradbiomed.2013.03.022
   Ntambi JM, 1999, J LIPID RES, V40, P1549
   OHARA Y, 1993, J CLIN INVEST, V91, P2546, DOI 10.1172/JCI116491
   PAGLIA DE, 1967, J LAB CLIN MED, V70, P158
   Papakonstantinou E, 2013, CURR VASC PHARMACOL, V11, P858, DOI 10.2174/15701611113116660176
   Pastore S, 2011, FREE RADICAL RES, V45, P585, DOI 10.3109/10715762.2011.560150
   Pataky Z, 2010, INT J OBESITY, V34, pS18, DOI 10.1038/ijo.2010.235
   Patel SB, 2008, CURR HYPERTENS REP, V10, P131, DOI 10.1007/s11906-008-0025-y
   PIGEOLET E, 1990, MECH AGEING DEV, V51, P283, DOI 10.1016/0047-6374(90)90078-T
   Pories WJ, 2010, OBESITY, V18, P865, DOI 10.1038/oby.2010.8
   Purkayastha S, 2013, MOL METAB, V2, P356, DOI 10.1016/j.molmet.2013.09.005
   REED DJ, 1980, ANAL BIOCHEM, V106, P55, DOI 10.1016/0003-2697(80)90118-9
   Roberson LL, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-14
   Robertson DS., 2013, BIOMEDICINE PREVENTI, V3, P83, DOI [10.1016/j.bionut.2012.10.010, DOI 10.1016/J.BIONUT.2012.10.010]
   Ruster C, 2008, FRONT BIOSCI-LANDMRK, V13, P944, DOI 10.2741/2734
   Samaan MC, 2011, DIABETOL METAB SYNDR, V3, DOI 10.1186/1758-5996-3-29
   Samad F, 2013, BLOOD, V122, P3415, DOI 10.1182/blood-2013-05-427708
   Samson SL, 2014, ENDOCRIN METAB CLIN, V43, P1, DOI 10.1016/j.ecl.2013.09.009
   Schwenger KJP, 2014, WORLD J GASTROENTERO, V20, P1712, DOI 10.3748/wjg.v20.i7.1712
   Seijkens T, 2014, FASEB J, V28, P2202, DOI 10.1096/fj.13-243105
   Sela S, 2005, J AM SOC NEPHROL, V16, P2431, DOI 10.1681/ASN.2004110929
   Serhan CN, 2008, NAT REV IMMUNOL, V8, P349, DOI 10.1038/nri2294
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Spritzer PM, 2015, REPRODUCTION, V149, pR219, DOI 10.1530/REP-14-0435
   Stefan N, 2008, ARCH INTERN MED, V168, P1609, DOI 10.1001/archinte.168.15.1609
   SUN Y, 1988, CLIN CHEM, V34, P497
   Tarantino G, 2013, WORLD J GASTROENTERO, V19, P3375, DOI 10.3748/wjg.v19.i22.3375
   Uchida K, 1999, J BIOL CHEM, V274, P2234, DOI 10.1074/jbc.274.4.2234
   Valacchi G, 2002, TOXICOLOGY, V179, P163, DOI 10.1016/S0300-483X(02)00240-8
   van Dam B, 2003, CARDIOVASC RES, V57, P563, DOI 10.1016/S0008-6363(02)00699-5
   Van Gaal LF, 2006, NATURE, V444, P875, DOI 10.1038/nature05487
   Wallert M, 2014, REDOX BIOL, V2, P495, DOI 10.1016/j.redox.2014.02.002
   World Health Organization, 1995, WHO TECHN REP SER, V854, P9
   World Health Organization, 2000, World Health Organ Tech Rep Ser, DOI DOI 10.1596/0-1952-1129-4
   Yan ML, 2011, CARDIOVASC DRUG THER, V25, P469, DOI 10.1007/s10557-011-6335-3
   Zhang HQ, 2009, TOXICOL IND HEALTH, V25, P269, DOI 10.1177/0748233709102209
   ZHANG YY, 1994, NATURE, V372, P425, DOI 10.1038/372425a0
NR 99
TC 10
Z9 10
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2015
VL 2015
AR 490613
DI 10.1155/2015/490613
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA CK5TF
UT WOS:000356287900001
PM 26090072
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU So, JS
   Chung, KM
   Seo, J
   Kim, B
   Chun, H
   Han, SN
   Chung, IM
AF So, Jisun
   Chung, Kyong-Mee
   Seo, Jihyeon
   Kim, Byungmi
   Chun, Hyejin
   Han, Sung Nim
   Chung, Ick-Mo
TI High intake of sweet foods and low life satisfaction can act as risk
   factors for acute coronary syndrome through synergistic interaction
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE coronary artery disease; sweets; life satisfaction; diet; psychology
ID SOFT DRINK CONSUMPTION; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   BEVERAGE CONSUMPTION; COFFEE CONSUMPTION; NATIONAL-HEALTH; MORTALITY;
   REHABILITATION; ASSOCIATION; DEPRESSION
AB PurposeDietary and psychological status contributes to the development of coronary artery disease. However, these lifestyle factors may vary depending on ethnic and environmental background, and secondary prevention programs dealing with these factors in a specific population are not well-established. We aimed to assess dietary and psychological characteristics in Korean patients with acute coronary syndrome (ACS) and analyze their interactions as independent risk factors for ACS. MethodsNinety-two patients with ACS (29 acute myocardial infarction and 63 unstable angina) and 69 controls were subjected to dietary and psychological analyses. Dietary intake was assessed by a food frequency questionnaire. Psychological depression and perceived stress were assessed using the Patient Health Questionnaire-9 and the Perceived Stress Scale, respectively. Eight domains of life satisfaction (marital/love relationship, leisure, standard of living, job, health, family life, sex life, and self) were assessed using the Domain Satisfaction Questionnaire (DSQ). ResultsThe ACS group had a higher consumption of sweets and fish/seafood, as well as higher levels of depressive symptoms. Additionally, they had lower DSQ scores in total, and all eight individual domains compared with the control group. In multivariate logistic regression analysis, sweet intake (OR 4.57, 95% CI: 1.94-11.40) and total DSQ scores (OR 0.34, 95% CI: 0.14-0.81) were identified as independent risk factors for ACS. Furthermore, these factors, which displayed a significant inverse correlation (& rho; = -0.23, p = 0.01), were determined as having a synergistic contribution to the development of ACS. ConclusionHigh sweet food intake and low life satisfaction can act as risk factors for ACS through a synergistic interaction, which emphasizes a demand for a more comprehensive approach to secondary prevention of ACS. In addition, these data highlight the role of positive psychological wellbeing factors in cardiovascular health.
C1 [So, Jisun; Han, Sung Nim] Seoul Natl Univ, Coll Human Ecol, Dept Food & Nutr, Seoul, South Korea.
   [Chung, Kyong-Mee; Seo, Jihyeon] Yonsei Univ, Dept Psychol, Seoul, South Korea.
   [Kim, Byungmi] Natl Canc Ctr, Natl Canc Control Inst, Div Canc Prevent, Goyang Si, South Korea.
   [Chun, Hyejin] Ewha Womans Univ, Mokdong Hosp, Dept Family Med, Sch Med, Seoul, South Korea.
   [Han, Sung Nim] Seoul Natl Univ, Res Inst Human Ecol, Seoul, South Korea.
   [Chung, Ick-Mo] Ewha Womans Univ, Mokdong Hosp, Div Cardiol, Sch Med, Seoul, South Korea.
C3 Seoul National University (SNU); Yonsei University; National Cancer
   Center - Korea (NCC); Ewha Womans University; Seoul National University
   (SNU); Ewha Womans University
RP Han, SN (corresponding author), Seoul Natl Univ, Coll Human Ecol, Dept Food & Nutr, Seoul, South Korea.; Han, SN (corresponding author), Seoul Natl Univ, Res Inst Human Ecol, Seoul, South Korea.; Chung, IM (corresponding author), Ewha Womans Univ, Mokdong Hosp, Div Cardiol, Sch Med, Seoul, South Korea.
EM snhan@snu.ac.kr; ickmo@ewha.ac.kr
OI Chung, Il-Moon/0000-0003-0163-7305
CR Afshin A, 2019, LANCET, V393, P1958, DOI 10.1016/S0140-6736(19)30041-8
   Ahn Y, 2007, EUR J CLIN NUTR, V61, P1435, DOI 10.1038/sj.ejcn.1602657
   Ahn Younjhin Ahn Younjhin, 2003, Nutritional Sciences, V6, P173
   Appel LJ, 1997, NEW ENGL J MED, V336, P1117, DOI 10.1056/NEJM199704173361601
   Arnett DK, 2019, CIRCULATION, V140, pE563, DOI [10.1016/j.jacc.2019.03.009, 10.1016/j.jacc.2019.03.010, 10.1161/CIR.0000000000000678, 10.1161/CIR.0000000000000677]
   Boehm JK, 2011, EUR HEART J, V32, P2672, DOI 10.1093/eurheartj/ehr203
   Caceres VD, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0198769
   Carney RM, 2017, NAT REV CARDIOL, V14, DOI 10.1038/nrcardio.2016.181
   Chen LW, 2010, CIRCULATION, V121, P2398, DOI 10.1161/CIRCULATIONAHA.109.911164
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   de Abreu D, 2013, CLIN NUTR, V32, P783, DOI 10.1016/j.clnu.2012.11.022
   De Hert M, 2018, DIALOGUES CLIN NEURO, V20, P31, DOI 10.31887/DCNS.2018.20.1/mdehert
   Dhingra R, 2007, CIRCULATION, V116, P480, DOI 10.1161/CIRCULATIONAHA.107.689935
   Ebbeling CB, 2006, PEDIATRICS, V117, P673, DOI 10.1542/peds.2005-0983
   Ford ES, 2007, NEW ENGL J MED, V356, P2388, DOI 10.1056/NEJMsa053935
   Francis T, 2019, CAN J CARDIOL, V35, P352, DOI 10.1016/j.cjca.2018.11.013
   German CA, 2022, AM J PREVENT CARDIOL, V12, DOI 10.1016/j.ajpc.2022.100432
   Grundy SM, 2019, J AM COLL CARDIOL, V73, P3168, DOI [10.1016/j.jacc.2018.11.002, 10.1161/CIR.0000000000000625, 10.1016/j.jacc.2018.11.003]
   Hendrie GA, 2018, NUTRIENTS, V10, DOI 10.3390/nu10020197
   Hu FB, 2010, PHYSIOL BEHAV, V100, P47, DOI 10.1016/j.physbeh.2010.01.036
   Huppert FA, 2003, BRIT J HEALTH PSYCH, V8, P107, DOI 10.1348/135910703762879246
   Jacques A, 2019, NEUROSCI BIOBEHAV R, V103, P178, DOI 10.1016/j.neubiorev.2019.05.021
   Je Y, 2014, ASIA PAC J CLIN NUTR, V23, P691, DOI 10.6133/apjcn.2014.23.4.11
   Kang Y, 2017, BRIT J NUTR, V117, P315, DOI 10.1017/S0007114517000046
   Kelsey MD, 2022, J AM COLL CARDIOL, V79, P1849, DOI 10.1016/j.jacc.2022.02.046
   Kim H, 2015, NUTR RES PRACT, V9, P496, DOI 10.4162/nrp.2015.9.5.496
   Kim HJ, 2014, DIABETES RES CLIN PR, V106, P145, DOI 10.1016/j.diabres.2014.07.007
   Kim SA, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102506
   Kim SO, 2021, KOREAN J FAM MED, V42, P212, DOI 10.4082/kjfm.20.0114
   Kivimäki M, 2018, NAT REV CARDIOL, V15, P215, DOI 10.1038/nrcardio.2017.189
   Koivumaa-Honkanen H, 2000, AM J EPIDEMIOL, V152, P983, DOI 10.1093/aje/152.10.983
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Kwak JH, 2019, EUR J NUTR, V58, P1009, DOI 10.1007/s00394-018-1617-1
   Lee HaengShin Lee HaengShin, 2014, Journal of Nutrition and Health, V47, P268, DOI 10.4163/jnh.2014.47.4.268
   Levav I, 2002, ISR J PSYCHIATR REL, V39, P50
   Lichtenstein AH, 2021, CIRCULATION, V144, pE472, DOI 10.1161/CIR.0000000000001031
   Mohan D, 2021, JAMA INTERN MED, V181, P631, DOI 10.1001/jamainternmed.2021.0036
   Naghavi M, 2017, LANCET, V390, P1151, DOI 10.1016/S0140-6736(17)32152-9
   Pivato CA, 2022, INT J CARDIOL, V364, P9, DOI 10.1016/j.ijcard.2022.05.056
   Raats M. M., 1992, Food Quality and Preference, V3, P89, DOI 10.1016/0950-3293(91)90028-D
   Rehm CD, 2016, JAMA-J AM MED ASSOC, V315, P2542, DOI 10.1001/jama.2016.7491
   Rozanski A, 1999, CIRCULATION, V99, P2192, DOI 10.1161/01.CIR.99.16.2192
   Ryff CD, 2006, PSYCHOTHER PSYCHOSOM, V75, P85, DOI 10.1159/000090892
   Sara JD, 2018, J AM HEART ASSOC, V7, DOI 10.1161/JAHA.117.008073
   Sayon-Orea C, 2015, CLIN NUTR, V34, P1133, DOI 10.1016/j.clnu.2014.11.010
   Schulze MB, 2004, JAMA-J AM MED ASSOC, V292, P927, DOI 10.1001/jama.292.8.927
   Sen S, 2008, BIOL PSYCHIAT, V64, P527, DOI 10.1016/j.biopsych.2008.05.005
   Shim JS, 2022, NUTR RES PRACT, V16, P476, DOI 10.4162/nrp.2022.16.4.476
   Shin S, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101467
   Supervia M, 2019, ECLINICALMEDICINE, V13, P46, DOI 10.1016/j.eclinm.2019.06.006
   Trudel-Fitzgerald C, 2021, PSYCHOSOM MED, V83, P402, DOI 10.1097/PSY.0000000000000948
   U.S. Department of Agriculture an d U.S. Department of Health and Human Services, 2020, DIET GUID AM 2020 20, V9th
   van Halewijn G, 2017, INT J CARDIOL, V232, P294, DOI 10.1016/j.ijcard.2016.12.125
   WCRF, 2015, Curbing Global Sugar Consumption: Effective Food Policy Actions to Help Promote Healthy Diets Tackle Obesity
   World Health Organization, 1998, WORLD HLTH REP 1998
   Wu JHY, 2012, BRIT J NUTR, V107, pS214, DOI 10.1017/S0007114512001602
   Yang QH, 2014, JAMA INTERN MED, V174, P516, DOI 10.1001/jamainternmed.2013.13563
NR 57
TC 1
Z9 1
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD AUG 7
PY 2023
VL 10
AR 1221916
DI 10.3389/fnut.2023.1221916
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA P4WV7
UT WOS:001050691100001
PM 37609484
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mak, KK
   Kong, WY
   Mak, A
   Sharma, VK
   Ho, RCM
AF Mak, Kwok Kei
   Kong, Wan Yee
   Mak, Anselm
   Sharma, Vijay Kumar
   Ho, Roger C. M.
TI Polymorphisms of the serotonin transporter gene and post-stroke
   depression: a meta-analysis
SO JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
LA English
DT Article
ID PROMOTER POLYMORPHISM; PROLACTIN RESPONSE; METABOLIC SYNDROME;
   LIFE-STRESS; 5-HTTLPR; ASSOCIATION; REGION; DISORDERS; RECEPTORS
AB Background Polymorphisms of the gene encoding the serotonin transporter-specifically, length variation in the serotonin-transporter-linked polymorphic region (5-HTTLPR), a single-nucleotide polymorphism in the 5-HTTLPR (rs25531), and variable number of tandem repeats (VNTR) in the second intron 2 (STin2)-have been implicated in the development of post-stroke depression (PSD).
   Objective To evaluate the association between polymorphisms of the serotonin transporter gene and PSD in the medical literature.
   Methods Random-effects meta-analyses were conducted on cross-sectional, case-control and cohort studies examining relations between polymorphisms of the gene encoding the serotonin transporter and the risk of developing PSD.
   Results Four studies comprising 260 stroke patients with PSD and 381 without were included. Our analyses showed a significant and positive association between the homozygous short variation (S) allele genotype of the 5-HTTLPR (SS) and PSD (random-effects pooled OR 2.05, 95% CI 1.41 to 2.98, z=3.79, p<0.001). Our analyses also showed a significant and negative association between the homozygous long variation (L) allele genotype of the 5-HTTLPR (LL) and PSD (random-effects OR 0.52, 95% CI 0.27 to 0.97, z=-2.07, p=0.039). No statistically significant association of PSD with heterozygous S and L allele genotype for 5-HTTLPR or other polymorphisms with rs25531 and STin2 VNTR was found. Heterogeneity and publication bias were not statistically significant. The major limitation of this meta-analysis is that we could not assess the interaction between stroke, environmental stress and PSD.
   Conclusions The 5-HTTLPR SS genotype may be a risk factor for PSD. The 5-HTTLPR LL genotype showed a significant negative association with PSD. Further research to assess the sensitivity and specificity of predicting the risk of developing PSD by screening for the 5-HTTLPR genotype in stroke patients is required.
C1 [Mak, Kwok Kei] Univ Hong Kong, Dept Community Med, Hong Kong, Hong Kong, Peoples R China.
   [Mak, Kwok Kei] Univ Hong Kong, Sch Publ Hlth, Hong Kong, Hong Kong, Peoples R China.
   [Kong, Wan Yee; Ho, Roger C. M.] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Singapore 119228, Singapore.
   [Mak, Anselm; Sharma, Vijay Kumar] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore 119228, Singapore.
C3 University of Hong Kong; University of Hong Kong; National University of
   Singapore; National University of Singapore
RP Ho, RCM (corresponding author), Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Level 9 NUHS Tower Block,1E Kent Ridge Rd, Singapore 119228, Singapore.
EM pcmrhcm@nus.edu.sg
RI Ho, Roger/ABD-9061-2021; sharma, Vijay/A-6733-2009
OI sharma, Vijay/0000-0002-8976-5696
CR Anguelova M, 2003, MOL PSYCHIATR, V8, P646, DOI 10.1038/sj.mp.4001336
   Bozina N, 2012, J PSYCHIATR RES, V46, P767, DOI 10.1016/j.jpsychires.2012.03.008
   Bridle C, 2012, BRIT J PSYCHIAT, V201, P180, DOI 10.1192/bjp.bp.111.095174
   Brummett BH, 2008, BEHAV GENET, V38, P34, DOI 10.1007/s10519-007-9172-1
   Caspi A, 2003, SCIENCE, V301, P386, DOI 10.1126/science.1083968
   Chotai J, 2003, PSYCHIAT RES, V119, P99, DOI 10.1016/S0165-1781(03)00112-4
   Fang J, 2011, STROKE, V42, P1461, DOI 10.1161/STROKEAHA.110.598672
   Hoffman JB, 2007, ENDOCRINE, V31, P202, DOI 10.1007/s12020-007-0017-8
   Huang CH, 2008, AM J MED GENET B, V147B, P903, DOI 10.1002/ajmg.b.30720
   Kendler KS, 2005, ARCH GEN PSYCHIAT, V62, P529, DOI 10.1001/archpsyc.62.5.529
   Kim JM, 2012, INT J GERIATR PSYCH, V27, P799, DOI 10.1002/gps.2787
   Kim JM, 2011, NEUROBIOL AGING, V32, P336, DOI 10.1016/j.neurobiolaging.2009.02.017
   Klingner CM, 2012, FRONT NEUROL NEUROSC, V30, P4, DOI 10.1159/000333373
   Kohen R, 2008, ARCH GEN PSYCHIAT, V65, P1296, DOI 10.1001/archpsyc.65.11.1296
   Kohen R, 2011, STROKE, V42, P2068, DOI 10.1161/STROKEAHA.110.611434
   Lan MY, 2009, J ENDOCRINOL INVEST, V32, P119, DOI 10.1007/BF03345699
   Lesch KP, 1996, SCIENCE, V274, P1527, DOI 10.1126/science.274.5292.1527
   MacKenzie A, 1999, P NATL ACAD SCI USA, V96, P15251, DOI 10.1073/pnas.96.26.15251
   Monroe SM, 2008, PSYCHOL SCI, V19, P947, DOI 10.1111/j.1467-9280.2008.02181.x
   Muldoon MF, 2007, STROKE, V38, P2228, DOI 10.1161/STROKEAHA.106.477638
   Muldoon MF, 2006, J CLIN ENDOCR METAB, V91, P718, DOI 10.1210/jc.2005-1654
   Muldoon MF, 1998, HYPERTENSION, V32, P972, DOI 10.1161/01.HYP.32.6.972
   Murphy DL, 2008, NAT REV NEUROSCI, V9, P85, DOI 10.1038/nrn2284
   Nakamura M, 2000, MOL PSYCHIATR, V5, P32, DOI 10.1038/sj.mp.4000698
   Ogilvie AD, 1997, MOL MED, V3, P90, DOI 10.1007/BF03401801
   Paolucci Stefano, 2008, Neuropsychiatr Dis Treat, V4, P145
   Persico AM, 2001, J NEUROSCI, V21, P6862, DOI 10.1523/JNEUROSCI.21-17-06862.2001
   Pezawas L, 2005, NAT NEUROSCI, V8, P828, DOI 10.1038/nn1463
   Ramasubbu R, 2006, J NEUROPSYCH CLIN N, V18, P96, DOI 10.1176/appi.neuropsych.18.1.96
   Ramasubbu R, 2008, CAN J PSYCHIAT, V53, P197, DOI 10.1177/070674370805300310
   Reist C, 2001, AM J MED GENET, V105, P363, DOI 10.1002/ajmg.1360
   Salichon N, 2001, J NEUROSCI, V21, P884, DOI 10.1523/JNEUROSCI.21-03-00884.2001
   Schürks M, 2010, CEPHALALGIA, V30, P1296, DOI 10.1177/0333102410362929
   Sen S, 2004, AM J MED GENET B, V127B, P85, DOI 10.1002/ajmg.b.20158
   Smith GS, 2004, NEUROPSYCHOPHARMACOL, V29, P2226, DOI 10.1038/sj.npp.1300552
   Sookoian S, 2010, CHRONOBIOL INT, V27, P1202, DOI 10.3109/07420528.2010.496913
   Wankerl M, 2010, CURR OPIN PSYCHIATR, V23, P582, DOI 10.1097/YCO.0b013e32833f0e3a
   Way BM, 2011, PSYCHOSOM MED, V73, P310, DOI 10.1097/PSY.0b013e31821195ed
   Whale R, 2000, PSYCHOPHARMACOLOGY, V150, P120, DOI 10.1007/s002130000432
   Zhao J, 2013, INT J OBESITY, V37, P140, DOI 10.1038/ijo.2012.8
NR 40
TC 60
Z9 66
U1 0
U2 25
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0022-3050
EI 1468-330X
J9 J NEUROL NEUROSUR PS
JI J. Neurol. Neurosurg. Psychiatry
PD MAR
PY 2013
VL 84
IS 3
BP 322
EP 328
DI 10.1136/jnnp-2012-303791
PG 7
WC Clinical Neurology; Psychiatry; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry; Surgery
GA 091HY
UT WOS:000315041400019
PM 23236014
DA 2025-06-11
ER

PT J
AU Martin, FPJ
   Montoliu, I
   Collino, S
   Scherer, M
   Guy, P
   Tavazzi, I
   Thorimbert, A
   Moco, S
   Rothney, MP
   Ergun, DL
   Beaumont, M
   Ginty, F
   Qanadli, SD
   Favre, L
   Giusti, V
   Rezzi, S
AF Martin, Francois-Pierre J.
   Montoliu, Ivan
   Collino, Sebastiano
   Scherer, Max
   Guy, Philippe
   Tavazzi, Isabelle
   Thorimbert, Anita
   Moco, Sofia
   Rothney, Megan P.
   Ergun, David L.
   Beaumont, Maurice
   Ginty, Fiona
   Qanadli, Salah D.
   Favre, Lucie
   Giusti, Vittorio
   Rezzi, Serge
TI Topographical Body Fat Distribution Links to Amino Acid and Lipid
   Metabolism in Healthy Non-Obese Women
SO PLOS ONE
LA English
DT Article
ID ADIPOSE-TISSUE; CARDIOVASCULAR-DISEASE; CARDIOMETABOLIC RISK; PLATELET
   ACTIVATION; INSULIN-RESISTANCE; OXIDATIVE STRESS; CENTRAL OBESITY;
   ABDOMINAL FAT; PLASMALOGENS; POPULATION
AB Visceral adiposity is increasingly recognized as a key condition for the development of obesity related disorders, with the ratio between visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) reported as the best correlate of cardiometabolic risk. In this study, using a cohort of 40 obese females (age: 25-45 y, BMI: 28-40 kg/m(2)) under healthy clinical conditions and monitored over a 2 weeks period we examined the relationships between different body composition parameters, estimates of visceral adiposity and blood/urine metabolic profiles. Metabonomics and lipidomics analysis of blood plasma and urine were employed in combination with in vivo quantitation of body composition and abdominal fat distribution using iDXA and computerized tomography. Of the various visceral fat estimates, VAT/SAT and VAT/total abdominal fat ratios exhibited significant associations with regio-specific body lean and fat composition. The integration of these visceral fat estimates with metabolic profiles of blood and urine described a distinct amino acid, diacyl and ether phospholipid phenotype in women with higher visceral fat. Metabolites important in predicting visceral fat adiposity as assessed by Random forest analysis highlighted 7 most robust markers, including tyrosine, glutamine, PC-O 44: 6, PC-O 44: 4, PC-O 42: 4, PC-O 40: 4, and PC-O 40: 3 lipid species. Unexpectedly, the visceral fat associated inflammatory profiles were shown to be highly influenced by inter-days and between-subject variations. Nevertheless, the visceral fat associated amino acid and lipid signature is proposed to be further validated for future patient stratification and cardiometabolic health diagnostics.
C1 [Martin, Francois-Pierre J.; Collino, Sebastiano; Scherer, Max; Guy, Philippe; Tavazzi, Isabelle; Thorimbert, Anita; Moco, Sofia; Rezzi, Serge] Nestec Ltd, Nestle Res Ctr, Metabol & Biomarkers, CH-1000 Lausanne, Switzerland.
   [Montoliu, Ivan] Nestec Ltd, Nestle Res Ctr, Appl Math, CH-1000 Lausanne, Switzerland.
   [Rothney, Megan P.] GE Global Res Ctr, Diagnost & Biomed Technol Org, Niskayuna, NY USA.
   [Ergun, David L.; Ginty, Fiona] GE Healthcare, Madison, WI USA.
   [Beaumont, Maurice] Nestec Ltd, Nestle Res Ctr, Clin Dev Unit, CH-1000 Lausanne, Switzerland.
   [Qanadli, Salah D.] Univ Lausanne Hosp, Dept Radiol, Cardiothorac & Vasc Unit, Lausanne, Switzerland.
   [Favre, Lucie; Giusti, Vittorio] Univ Lausanne Hosp, Dept Med, Serv Endocrinol Diabetol & Metab, Lausanne, Switzerland.
C3 Nestle SA; Nestle Research Center; Nestle SA; Nestle Research Center;
   General Electric; General Electric; Nestle SA; Nestle Research Center;
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV)
RP Martin, FPJ (corresponding author), Nestle Inst Hlth Sci SA, Mol Biomarkers, Lausanne, Switzerland.
EM francois-pierre.martin@rd.nestle.com; serge.rezzi@rd.nestle.com
RI Moco, Sofia/AAN-7187-2021
OI Guy, philippe/0000-0002-2968-8625; QANADLI, Salah
   Dine/0000-0003-1330-660X; Martin, Francois-Pierre/0000-0003-1373-5367;
   Moco, Sofia/0000-0001-8170-8876; Ginty, Fiona/0000-0001-6638-683X;
   Rezzi, Serge/0000-0002-0691-2153
CR Basili S, 2006, J AM COLL CARDIOL, V48, P2531, DOI 10.1016/j.jacc.2006.08.040
   Batra A, 2012, DIGEST DIS, V30, P70, DOI 10.1159/000335722
   Baur P, 2011, J PROTEOME RES, V10, P5523, DOI 10.1021/pr2007973
   Borruel S, 2013, J CLIN ENDOCR METAB, V98, P1254, DOI 10.1210/jc.2012-3698
   Breiman L., 2001, Machine Learning, V45, P5, DOI 10.1023/A:1010933404324
   Chakrabarti SK, 2011, AM J PHYSIOL-ENDOC M, V300, pE175, DOI 10.1152/ajpendo.00203.2010
   Chakrabarti SK, 2009, OBESITY, V17, P1657, DOI 10.1038/oby.2009.192
   Chiolero A, 2007, Rev Med Suisse, V3, P1262
   Cloarec O, 2005, ANAL CHEM, V77, P517, DOI 10.1021/ac048803i
   Davì G, 2002, JAMA-J AM MED ASSOC, V288, P2008, DOI 10.1001/jama.288.16.2008
   DESPRES JP, 1988, PREV MED, V17, P423, DOI 10.1016/0091-7435(88)90041-2
   DONAHUE RP, 1987, LANCET, V2, P1215
   Dulloo AG, 2010, INT J OBESITY, V34, pS1, DOI 10.1038/ijo.2010.233
   Ezeh U, 2013, J CLIN ENDOCR METAB, V98, P1541, DOI 10.1210/jc.2012-2937
   Fiehn O, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015234
   Floegel A, 2013, DIABETES, V62, P639, DOI 10.2337/db12-0495
   FOLSOM AR, 1993, JAMA-J AM MED ASSOC, V269, P483, DOI 10.1001/jama.269.4.483
   Fox CS, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002695
   Huffman KM, 2009, DIABETES CARE, V32, P1678, DOI 10.2337/dc08-2075
   Kaess BM, 2012, DIABETOLOGIA, V55, P2622, DOI 10.1007/s00125-012-2639-5
   KALKHOFF RK, 1983, J LAB CLIN MED, V102, P621
   Kang SM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027694
   Klannemark M, 1998, DIABETOLOGIA, V41, P1516, DOI 10.1007/s001250051099
   Lackey DE, 2013, AM J PHYSIOL-ENDOC M, V304, pE1175, DOI 10.1152/ajpendo.00630.2012
   LAPIDUS L, 1984, BMJ-BRIT MED J, V289, P1257, DOI 10.1136/bmj.289.6454.1257
   Lasserre AM, 2007, SWISS MED WKLY, V137, P157
   Lee MJ, 2013, MOL ASPECTS MED, V34, P1, DOI 10.1016/j.mam.2012.10.001
   Leitinger N, 1997, THROMB RES, V86, P337, DOI 10.1016/S0049-3848(97)00077-7
   LEMIEUX S, 1994, DIABETOLOGIA, V37, P757, DOI 10.1007/s001250050176
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Li M, 2008, P NATL ACAD SCI USA, V105, P2117, DOI 10.1073/pnas.0712038105
   Maeba R, 2007, J ATHEROSCLER THROMB, V14, P12, DOI 10.5551/jat.14.12
   Martin FPJ, 2008, MOL SYST BIOL, V4, DOI 10.1038/msb.2008.40
   McIntyre TM, 2009, J LIPID RES, V50, pS255, DOI 10.1194/jlr.R800024-JLR200
   Newgard CB, 2009, CELL METAB, V9, P311, DOI 10.1016/j.cmet.2009.02.002
   Nicholson JK, 2005, NAT REV MICROBIOL, V3, P431, DOI 10.1038/nrmicro1152
   Okazaki M, 2005, ARTERIOSCL THROM VAS, V25, P578, DOI 10.1161/01.ATV.0000155017.60171.88
   Park SH, 2007, J AM COLL NUTR, V26, P321, DOI 10.1080/07315724.2007.10719618
   Peairs AD, 2011, NUTR J, V10, DOI 10.1186/1475-2891-10-122
   Pietiläinen KH, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000218
   Rhee EP, 2011, J CLIN INVEST, V121, P1402, DOI 10.1172/JCI44442
   Rothney MP, 2012, J CLIN DENSITOM
   Samaras K, 1999, ANN INTERN MED, V130, P873, DOI 10.7326/0003-4819-130-11-199906010-00002
   SCHRAKAMP G, 1985, BIOCHIM BIOPHYS ACTA, V833, P170, DOI 10.1016/0005-2760(85)90266-8
   Smith SC, 2007, CURR MED RES OPIN, V23, P29, DOI 10.1185/030079906X159489
   SNYDER F, 1995, BBA-LIPID LIPID MET, V1254, P231, DOI 10.1016/0005-2760(94)00192-2
   Sorensen TIA, 2006, PLOS CLIN TRIALS, V1, DOI 10.1371/journal.pctr.0010012
   Suhre K, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013953
   Szuldrzynski K, 2010, POL ARCH MED WEWN, V120, P19
   Szymanska E, 2012, OMICS, V16, P652, DOI 10.1089/omi.2012.0062
   Terán-García M, 2007, APPL PHYSIOL NUTR ME, V32, P89, DOI 10.1139/h06-102
   Trygg J, 2003, J CHEMOMETR, V17, P53, DOI 10.1002/cem.775
   Viguerie N, 2005, DIABETOLOGIA, V48, P123, DOI 10.1007/s00125-004-1618-x
   Wallner S, 2011, CHEM PHYS LIPIDS, V164, P573, DOI 10.1016/j.chemphyslip.2011.06.008
   Wang TJ, 2011, NAT MED, V17, P448, DOI 10.1038/nm.2307
   Wang-Sattler R, 2012, MOL SYST BIOL, V8, DOI 10.1038/msb.2012.43
   Wildman RP, 2008, ARCH INTERN MED, V168, P1617, DOI 10.1001/archinte.168.15.1617
   WOLD S, 1987, CHEMOMETR INTELL LAB, V2, P37, DOI 10.1016/0169-7439(87)80084-9
   Wold S., 1987, PLS M FRANKF
   Wu B, 2009, ENDOCR J, V56, P773, DOI 10.1507/endocrj.K08E-332
   Yamakado M, 2012, CLIN OBES, V2, P29, DOI 10.1111/j.1758-8111.2012.00039.x
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
   Zoeller RA, 1999, BIOCHEM J, V338, P769, DOI 10.1042/0264-6021:3380769
NR 63
TC 38
Z9 40
U1 1
U2 16
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 11
PY 2013
VL 8
IS 9
AR e73445
DI 10.1371/journal.pone.0073445
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 248VW
UT WOS:000326734500032
PM 24039943
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Gunduz, G
   Beler, M
   Unal, I
   Cansiz, D
   Emekli-Alturfan, E
   Kose, KN
AF Gunduz, Gizem
   Beler, Merih
   Unal, Ismail
   Cansiz, Derya
   Emekli-Alturfan, Ebru
   Kose, Kemal Naci
TI Gingipain Injection Affects Intestinal Oxidant- Antioxidant Status and
   Alkaline Phosphatase in Overfed Zebrafish
SO EXPERIMED
LA English
DT Article
DE Gingipain; zebrafish; oxidative stress
ID PORPHYROMONAS-GINGIVALIS; LIPID-PEROXIDATION; METABOLIC SYNDROME;
   OXIDATIVE STRESS; PERIODONTITIS
AB Objective: Porphyromonas gingivalis ( P. gingivalis), ), a major periodontopathogen, is associated with overfeeding disorders, including metabolic syndrome. Gingipains are one of the most powerful endotoxins of P. gingivalis. . Our aim was to reveal the effects of gingipain injections on the intestinal oxidant-antioxidant status and alkaline phosphatase (ALP) activity in overfed zebrafish. Materials and Methods: Four groups of healthy adult zebrafish were placed in random tanks as C: Control (n=15); GP: Gingipain (n=15); OF: Overfeeding (n=15); and OF+GP: Overfeeding+Gingipain (n=15) groups. At the end of the experiment, levels of intestinal lipid peroxidation (LPO) and ALP, glutathione S-transferase (GST), and catalase (CAT) activities were evaluated. Results: Intestinal LPO was significantly lower in the GP and OF groups compared to C. Gingipain injection in OF (OF+GP) significantly elevated LPO when compared to C, GP, and OF groups. ALP activities decreased significantly in the GP, OF, and OF+GP compared to C. GST activities increased significantly in the GP when compared to C. Decreased GST activities were observed in the OF and OF+GP. This decrease was less in OF+GP. CAT activities significantly decreased in all groups when compared to C. Conclusion: Our findings demonstrate that gingipain injection alters the ALP activity and intestinal oxidant-antioxidant status in overfed zebrafish.
C1 [Gunduz, Gizem] Marmara Univ, Inst Hlth Sci, Dept Periodontol, Istanbul, Turkiye.
   [Beler, Merih; Unal, Ismail] Marmara Univ, Inst Hlth Sci, Dept Biochem, Istanbul, Turkiye.
   [Cansiz, Derya] Istanbul Medipol Univ, Fac Med, Dept Biochem, Istanbul, Turkiye.
   [Emekli-Alturfan, Ebru] Marmara Univ, Fac Dent, Dept Biochem, Nisantasi, Turkiye.
   [Kose, Kemal Naci] Marmara Univ, Fac Dent, Dept Periodontol, Istanbul, Turkiye.
C3 Marmara University; Marmara University; Istanbul Medipol University;
   Marmara University; Marmara University
RP Kose, KN (corresponding author), Marmara Univ, Fac Dent, Dept Periodontol, Istanbul, Turkiye.
EM kemkose@superonline.com
RI CANSIZ, Derya/ABF-7508-2020; Emekli-Alturfan, Ebru/X-2758-2019; Kose,
   Kemal/AAA-1941-2019; Ünal, İsmail/GPG-1965-2022
FU Marmara University Scientific Research and Project Commission
   [TDK-2021-10420]
FX This project was supported by Marmara University Scientific Research and
   Project Commission, Project No: TDK-2021-10420.
CR AEBI H, 1984, METHOD ENZYMOL, V105, P121
   Bullon P, 2009, J DENT RES, V88, P503, DOI 10.1177/0022034509337479
   Dandin E, 2022, OBES RES CLIN PRACT, V16, P23, DOI 10.1016/j.orcp.2022.01.002
   Dominy SS, 2019, SCI ADV, V5, DOI 10.1126/sciadv.aau3333
   Dong ZJ, 2022, FRONT CELL INFECT MI, V12, DOI 10.3389/fcimb.2022.858902
   Estaki M, 2014, WORLD J GASTROENTERO, V20, P15650, DOI 10.3748/wjg.v20.i42.15650
   Farrugia C, 2021, FEBS J, V288, P1479, DOI 10.1111/febs.15486
   Frohnert BI, 2014, ADIPOCYTE, V3, P224, DOI [10.4161/adip.28851, 10.2337/db13-0777]
   HABIG WH, 1974, J BIOL CHEM, V249, P7130
   Karaman GE, 2020, CELL MOL BIOL, V66, P41, DOI 10.14715/cmb/2020.66.8.7
   Kose K., 2022, Journal of Clinical Sciences (Abstracts), The 26th International Congress of Turkish Dental Association, September 8-11, (Suppplements), V11, P596
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   Maloy KJ, 2011, NATURE, V474, P298, DOI 10.1038/nature10208
   Mei F, 2020, PATHOGENS, V9, DOI 10.3390/pathogens9110944
   Molnár K, 2012, WORLD J GASTROENTERO, V18, P3254, DOI 10.3748/wjg.v18.i25.3254
   Mysak J, 2014, J IMMUNOL RES, V2014, DOI 10.1155/2014/476068
   Nibali L, 2013, J CLIN ENDOCR METAB, V98, P913, DOI 10.1210/jc.2012-3552
   Nunes JM, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.01551
   Oka Takehiko, 2010, BMC Physiol, V10, P21, DOI 10.1186/1472-6793-10-21
   Panjamurthy K, 2005, CELL MOL BIOL LETT, V10, P255
   Röth E, 2011, EXP CLIN CARDIOL, V16, P92
   Tsuzuno T, 2021, J PERIODONTAL RES, V56, P275, DOI 10.1111/jre.12816
   Walter K., 1974, Methods of Enzymatic Analysis, V2, P856
   Widziolek M, 2016, SCI REP-UK, V6, DOI 10.1038/srep36023
   Wilensky A, 2017, J PERIODONTAL RES, V52, P285, DOI 10.1111/jre.12393
   Xu WZ, 2020, ADV PROTEIN CHEM STR, V120, P45, DOI 10.1016/bs.apcsb.2019.12.001
   YAGI K, 1984, METHOD ENZYMOL, V105, P328
   Zang LQ, 2013, ZEBRAFISH, V10, P425, DOI 10.1089/zeb.2012.0862
NR 28
TC 2
Z9 2
U1 0
U2 1
PU ISTANBUL UNIV
PI ISTANBUL
PA Rektorlugu, Beyazit, Fatih, ISTANBUL, 34452, Turkiye
EI 2667-5846
J9 EXPERIMED
JI Experimed
PY 2023
VL 13
IS 2
BP 80
EP 85
DI 10.26650/experimed.1268503
PG 6
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA H2Y5X
UT WOS:001322146800002
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Chang, YT
   Lin, HC
   Chang, WN
   Tsai, NW
   Huang, CC
   Wang, HC
   Kung, CT
   Su, YJ
   Lin, WC
   Cheng, BC
   Su, CM
   Chen, TY
   Chiang, YF
   Lu, CH
AF Chang, Ya-Ting
   Lin, Hsin-Ching
   Chang, Wen-Neng
   Tsai, Nai-Wen
   Huang, Chih-Cheng
   Wang, Hung-Chen
   Kung, Chia-Te
   Su, Yu-Jih
   Lin, Wei-Che
   Cheng, Ben-Chung
   Su, Chih-Min
   Chen, Ting-Yao
   Chiang, Yi-Fang
   Lu, Cheng-Hsien
TI Impact of inflammation and oxidative stress on carotid intima-media
   thickness in obstructive sleep apnea patients without metabolic syndrome
SO JOURNAL OF SLEEP RESEARCH
LA English
DT Article
DE atherosclerotic disease; endothelium; inflammatory; polysomnography;
   sleep disorder
ID INTERCELLULAR-ADHESION MOLECULE-1; ARTERY INTIMA; INTERMITTENT HYPOXIA;
   PRACTICE PARAMETERS; P-SELECTIN; ATHEROSCLEROSIS; SEVERITY; DISEASE;
   MARKERS; STROKE
AB Obstructive sleep apnea (OSA) increases the risk of cardiovascular diseases, and carotid intima-media thickness (IMT) is a good indicator of the severity of atherosclerotic disease. This study tested the hypothesis that inflammation and oxidative stress determined carotid IMT in patients with OSA. The carotid IMT, mean systolic and diastolic pressure (night and morning) were significantly higher and the level of thiols and highdensity lipoprotein were significantly lower in our 121 OSA patients than in 27 controls (P < 0.05). The apnea/hypopnea index was correlated positively with E-selectin (r = 0.222, P = 0.014), total cholesterol (r = 0.185, P = 0.042), low-density lipoprotein (r = 0.264, P = 0.003) and HbA1c levels (r = 0.304, P = 0.001), but inversely with high-density lipoprotein level (r = -0.203, P = 0.025) in the 121 patients with OSA. In OSA subjects, multiple linear regression analysis revealed that age, systolic blood pressure and intercellular cell adhesion molecule-1 level associated independently with carotid IMT. Besides both age and systolic blood pressure, our study demonstrated that intercellular cell adhesion molecule-1 level was associated significantly with carotid IMT in those patients who had OSA but without metabolic syndrome.
C1 [Chang, Ya-Ting; Chang, Wen-Neng; Tsai, Nai-Wen; Huang, Chih-Cheng; Chen, Ting-Yao; Lu, Cheng-Hsien] Chang Gung Univ Coll Med, Kaohsiung Med Ctr, Chang Gung Mem Hosp, Dept Neurol, Kaohsiung, Taiwan.
   [Chang, Ya-Ting; Chiang, Yi-Fang] Pingtung Christian Hosp, Neurol Sect, Dept Med, Pingtung, Taiwan.
   [Lin, Hsin-Ching] Chang Gung Univ Coll Med, Kaohsiung Med Ctr, Chang Gung Mem Hosp, Dept Otolaryngol, Kaohsiung, Taiwan.
   [Lin, Hsin-Ching] Chang Gung Univ Coll Med, Kaohsiung Med Ctr, Chang Gung Mem Hosp, Sleep Ctr, Kaohsiung, Taiwan.
   [Wang, Hung-Chen] Chang Gung Univ Coll Med, Kaohsiung Med Ctr, Chang Gung Mem Hosp, Dept Neurosurg, Kaohsiung, Taiwan.
   [Kung, Chia-Te; Su, Chih-Min] Chang Gung Univ Coll Med, Kaohsiung Med Ctr, Chang Gung Mem Hosp, Dept Emergency Med, Kaohsiung, Taiwan.
   [Su, Yu-Jih; Cheng, Ben-Chung] Chang Gung Univ Coll Med, Kaohsiung Med Ctr, Chang Gung Mem Hosp, Dept Med, Kaohsiung, Taiwan.
   [Lin, Wei-Che] Chang Gung Univ Coll Med, Kaohsiung Med Ctr, Chang Gung Mem Hosp, Dept Radiol, Kaohsiung, Taiwan.
   [Cheng, Ben-Chung; Lu, Cheng-Hsien] Natl Sun Yat Sen Univ, Dept Biol Sci, Kaohsiung, Taiwan.
   [Lu, Cheng-Hsien] Xiamen Chang Gung Mem Hosp, Dept Neurol, Xiamen, Peoples R China.
C3 Chang Gung University; Chang Gung Memorial Hospital; Chang Gung
   University; Chang Gung Memorial Hospital; Chang Gung Memorial Hospital;
   Chang Gung University; Chang Gung University; Chang Gung Memorial
   Hospital; Chang Gung Memorial Hospital; Chang Gung University; Chang
   Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital; Chang Gung University; National Sun Yat Sen University
RP Lu, CH (corresponding author), Chang Gung Mem Hosp, Dept Neurol, 123 Ta Pei Rd, Kaohsiung, Taiwan.
EM chlu99@ms44.url.com.tw
RI Huang, Chien-Lung/O-2028-2013; Chang, Ya-Ting/E-1761-2012; wang,
   yichun/IXW-7812-2023; Chaou, Chung-Hsien/AAZ-7344-2020; Su,
   Yu-Jih/AGJ-4763-2022
OI Su, Yu-Jih/0000-0002-7274-3458
FU National Research Program for Biopharmaceuticals
   [101-2314-B-182A-084-MY3, 104-2314-B-182A-028-MY2]
FX This study was supported by grants from the National Research Program
   for Biopharmaceuticals (101-2314-B-182A-084-MY3,
   104-2314-B-182A-028-MY2).
CR Amer Diabet Assoc, 2009, DIABETES CARE, V32, pS62, DOI [10.2337/dc09-S062, 10.2337/dc10-s062]
   Aurora RN, 2012, SLEEP, V35, P17, DOI 10.5665/sleep.1580
   Baguet JP, 2005, CHEST, V128, P3407, DOI 10.1378/chest.128.5.3407
   Chami HA, 2013, SLEEP, V36, P763, DOI 10.5665/sleep.2644
   CHEN CC, 1995, J IMMUNOL, V155, P3538
   Cheung LSL, 2011, PHYS BIOL, V8, DOI 10.1088/1478-3975/8/1/015013
   Ciccone MM, 2014, MOLECULES, V19, P1651, DOI 10.3390/molecules19021651
   Drager LF, 2005, AM J RESP CRIT CARE, V172, P613, DOI 10.1164/rccm.200503-340OC
   Dyken ME, 1996, STROKE, V27, P401, DOI 10.1161/01.STR.27.3.401
   Epstein LJ, 2009, J CLIN SLEEP MED, V5, P263
   Flemons WW, 1999, SLEEP, V22, P667, DOI 10.1093/sleep/22.5.667
   Fotis L, 2012, IN VIVO, V26, P243
   Gorzewska A, 2013, LUNG, V191, P397, DOI 10.1007/s00408-013-9471-7
   Kawano Y, 2012, METABOLISM, V61, P186, DOI 10.1016/j.metabol.2011.06.004
   Kostrzewska M, 2015, ADV EXP MED BIOL, V839, P61, DOI 10.1007/5584_2014_45
   Kushida CA, 2005, SLEEP, V28, P499, DOI 10.1093/sleep/28.4.499
   Lévy P, 2009, PROG CARDIOVASC DIS, V51, P400, DOI 10.1016/j.pcad.2008.03.001
   Li JG, 2005, CIRC RES, V97, P698, DOI 10.1161/01.RES.0000183879.60089.a9
   Lu CH, 2015, CLIN CHIM ACTA, V448, P1, DOI 10.1016/j.cca.2015.05.023
   Minoguchi K, 2005, AM J RESP CRIT CARE, V172, P625, DOI 10.1164/rccm.200412-1652OC
   Nakashima Y, 1998, ARTERIOSCL THROM VAS, V18, P842, DOI 10.1161/01.ATV.18.5.842
   O'Leary DH, 1999, NEW ENGL J MED, V340, P14, DOI 10.1056/NEJM199901073400103
   O'Leary DH, 2002, AM J CARDIOL, V90, p18L, DOI 10.1016/S0002-9149(02)02957-0
   OKADA Y, 1994, STROKE, V25, P202, DOI 10.1161/01.STR.25.1.202
   OLSON LG, 1995, AM J RESP CRIT CARE, V152, P711, DOI 10.1164/ajrccm.152.2.7633731
   Papanas N, 2009, VASC HEALTH RISK MAN, V5, P751
   Patil SP, 2007, CHEST, V132, P325, DOI 10.1378/chest.07-0040
   Peter K, 1997, ARTERIOSCL THROM VAS, V17, P505, DOI 10.1161/01.ATV.17.3.505
   Pradhan AD, 2002, CIRCULATION, V106, P820, DOI 10.1161/01.CIR.0000025636.03561.EE
   Punjabi NM, 2004, AM J EPIDEMIOL, V160, P521, DOI 10.1093/aje/kwh261
   Rechtschaffen A., 1968, MANUAL STANDARDIZED
   Ryan S, 2005, CIRCULATION, V112, P2660, DOI 10.1161/CIRCULATIONAHA.105.556746
   SALONEN R, 1991, J INTERN MED, V229, P225, DOI 10.1111/j.1365-2796.1991.tb00336.x
   Silvestrini M, 2002, STROKE, V33, P1782, DOI 10.1161/01.STR.0000019123.47840.2D
   Suzuki T, 2004, SLEEP, V27, P129, DOI 10.1093/sleep/27.1.129
   Tan TY, 2009, CLIN RADIOL, V64, P1097, DOI 10.1016/j.crad.2009.06.009
   Tan TY, 2012, NEUROLOGIST, V18, P277, DOI 10.1097/NRL.0b013e3182675344
   Thunström E, 2015, SLEEP, V38, P463, DOI 10.5665/sleep.4510
   Ziegler MG, 1997, SLEEP, V20, P224, DOI 10.1093/sleep/20.3.224
NR 39
TC 13
Z9 16
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1105
EI 1365-2869
J9 J SLEEP RES
JI J. Sleep Res.
PD APR
PY 2017
VL 26
IS 2
BP 151
EP 158
DI 10.1111/jsr.12477
PG 8
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA EQ4ZO
UT WOS:000398090400006
PM 27896929
DA 2025-06-11
ER

PT J
AU Hopps, E
   Lo Presti, R
   Montana, M
   Canino, B
   Averna, MR
   Caimi, G
AF Hopps, E.
   Lo Presti, R.
   Montana, M.
   Canino, B.
   Averna, M. R.
   Caimi, G.
TI Study of the Correlations among Some Parameters of the Oxidative Status,
   Gelatinases, and Their Inhibitors in a Group of Subjects with Metabolic
   Syndrome
SO MEDIATORS OF INFLAMMATION
LA English
DT Article
ID MATRIX-METALLOPROTEINASE EXPRESSION; NITRIC-OXIDE; TISSUE INHIBITOR;
   INSULIN-RESISTANCE; PROTEIN OXIDATION; HIGH GLUCOSE;
   MATRIX-METALLOPROTEINASE-9; STRESS; HYPERTENSION; PEROXYNITRITE
AB Our aim was to examine some parameters of oxidative status, gelatinases, and their inhibitors and to evaluate their interrelationships in subjects with metabolic syndrome (MS). We enrolled 65 MS subjects, subdivided according to the presence or not of diabetes mellitus. We examined lipid peroxidation (expressed as thiobarbituric acid reacting substances, TBARS), protein oxidation (expressed as carbonyl groups), nitric oxide metabolites (NOx), total antioxidant status (TAS), MMP-2, MMP-9, TIMP-1, and TIMP-2. We found that MS subjects, diabetics and nondiabetics, showed an increase in TBARS, PC, and NOx. A significant decrease in TAS was observed only in nondiabetic MS subjects in comparison with diabetic MS subjects. We observed increased concentrations of MMP-2, MMP-9, TIMP-1, and TIMP-2, higher in diabetic subjects. Our data showed a positive correlation between TAS and MMP-2, TAS and MMP-9, and TAS and MMP-9/TIMP-1 and a negative correlation between TBARS and MMP-2 in diabetic MS subjects in the entire group. In MS subjects a prooxidant status and increased levels of gelatinases and their inhibitors are evident although the correlations between oxidative stress and MMPs or TIMPs are controversial and need further investigation.
C1 [Hopps, E.; Lo Presti, R.; Montana, M.; Canino, B.; Averna, M. R.; Caimi, G.] Univ Palermo, Dipartimento Biomed Med Interna & Specialist, I-90100 Palermo, Italy.
C3 University of Palermo
RP Hopps, E (corresponding author), Univ Palermo, Dipartimento Biomed Med Interna & Specialist, Via Vespro 129, I-90100 Palermo, Italy.
EM eugenia.hopps@unipa.it
RI Montaña, Fernanda/ADG-6031-2022; Averna, Maurizio/U-9527-2017; LO
   PRESTI, Rosalia/J-5394-2016
OI Averna, Maurizio/0000-0003-3558-9209; LO PRESTI,
   Rosalia/0000-0002-7491-568X; canino, baldassare/0000-0001-6024-331X;
   Caimi, Gregorio/0000-0001-8964-255X
CR Al-Hamodi Z, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-23
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Amalinei Cornelia, 2007, Rom J Morphol Embryol, V48, P323
   Amaro S, 2009, J NEUROL, V256, P651, DOI 10.1007/s00415-009-0153-6
   Balasoiu M, 2014, ROM J MORPHOL EMBRYO, V55, P29
   Bittner A, 2010, INT J CARDIOL, V143, P98, DOI 10.1016/j.ijcard.2008.11.188
   Bourboulia D, 2010, SEMIN CANCER BIOL, V20, P161, DOI 10.1016/j.semcancer.2010.05.002
   Brown DJ, 2004, MOL VIS, V10, P281
   Caimi G, 2013, DIABETES METAB SYND, V7, P38, DOI 10.1016/j.dsx.2013.02.013
   Caimi G, 2012, DIABETES METAB SYND, V6, P132, DOI 10.1016/j.dsx.2012.09.012
   Castro MM, 2011, PHARMACOL RES, V64, P567, DOI 10.1016/j.phrs.2011.04.002
   Castro MM, 2009, FREE RADICAL BIO MED, V46, P1298, DOI 10.1016/j.freeradbiomed.2009.02.011
   Creemers EEJM, 2001, CIRC RES, V89, P201, DOI 10.1161/hh1501.094396
   Death AK, 2003, ATHEROSCLEROSIS, V168, P263, DOI 10.1016/S0021-9150(03)00140-0
   DeBoer MD, 2013, NUTRITION, V29, P379, DOI 10.1016/j.nut.2012.07.003
   Dhingra R, 2009, CIRCULATION, V119, P1101, DOI 10.1161/CIRCULATIONAHA.108.821769
   Di Massimo C, 2006, LIFE SCI, V78, P1163, DOI 10.1016/j.lfs.2005.06.037
   Donnini S, 2008, FEBS LETT, V582, P1135, DOI 10.1016/j.febslet.2008.02.080
   Esteban-Pretel G, 2013, J NUTR BIOCHEM, V24, P137, DOI 10.1016/j.jnutbio.2012.03.010
   Flamant M, 2007, HYPERTENSION, V50, P212, DOI 10.1161/HYPERTENSIONAHA.107.089631
   Forstermann U, 1995, Adv Pharmacol, V34, P171
   Fuentes E, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/136584
   Gai XB, 2010, CLIN CHIM ACTA, V411, P719, DOI 10.1016/j.cca.2010.02.002
   Hansson J, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016185
   Hayden MR, 2005, CARDIOVASC DIABETOL, V4, DOI 10.1186/1475-2840-4-9
   Ho FM, 2007, J CELL BIOCHEM, V101, P442, DOI 10.1002/jcb.21192
   Hopps E, 2013, NUTR METAB CARDIOVAS, V23, pE17, DOI 10.1016/j.numecd.2013.01.010
   Hopps E, 2012, EUR J INTERN MED, V23, P99, DOI 10.1016/j.ejim.2011.09.012
   Hopps E, 2010, NUTR METAB CARDIOVAS, V20, P72, DOI 10.1016/j.numecd.2009.06.002
   Hopps E, 2013, J INVEST MED, V61, P978, DOI 10.2310/JIM.0b013e318294e9da
   Hopps E, 2013, CLIN INVEST MED, V36, pE1
   Jaiswal A, 2011, BIOINFORMATION, V6, P23, DOI 10.6026/97320630006023
   Kameda K, 2003, EUR HEART J, V24, P2180, DOI 10.1016/j.ehj.2003.09.022
   Kandasamy AD, 2010, CARDIOVASC RES, V85, P413, DOI 10.1093/cvr/cvp268
   Kar S, 2010, RESP PHYSIOL NEUROBI, V174, P299, DOI 10.1016/j.resp.2010.08.019
   Kelly PJ, 2008, STROKE, V39, P100, DOI 10.1161/STROKEAHA.107.488189
   Khezheva FM, 2007, KARDIOLOGIYA, V47, P10
   Koken T, 2010, J MED TOXICOL, V6, P126, DOI 10.1007/s13181-010-0081-y
   Liu P, 2006, CAN J CARDIOL, V22, p25B, DOI 10.1016/S0828-282X(06)70983-7
   Lo HM, 2013, J LEUKOCYTE BIOL, V93, P723, DOI 10.1189/jlb.0512238
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   MILLER NJ, 1993, CLIN SCI, V84, P407, DOI 10.1042/cs0840407
   MONCADA S, 1991, PHARMACOL REV, V43, P109
   Nagareddy PR, 2012, BRIT J PHARMACOL, V165, P705, DOI 10.1111/j.1476-5381.2011.01583.x
   Nims Raymond W., 1995, Methods (Orlando), V7, P48, DOI 10.1006/meth.1995.1007
   Odegaard JI, 2013, SCIENCE, V339, P172, DOI 10.1126/science.1230721
   Pawlak K, 2010, NEPHRON CLIN PRACT, V115, pC251, DOI 10.1159/000313483
   Rajavashisth TB, 1999, J BIOL CHEM, V274, P11924, DOI 10.1074/jbc.274.17.11924
   Romeo GR, 2012, ARTERIOSCL THROM VAS, V32, P1771, DOI 10.1161/ATVBAHA.111.241869
   Rydén M, 2012, J INTERN MED, V272, P371, DOI [10.1111/j.1365-2796.2012.2534.x, 10.1111/j.1365-2796.2012.2534x.x]
   Schonbeck U, 1997, CIRC RES, V81, P448, DOI 10.1161/01.RES.81.3.448
   Sevin G, 2013, EUR J PHARMACOL, V706, P98, DOI 10.1016/j.ejphar.2013.02.052
   Shaomei S., 2014, MEDIAT INFLAMM, V2014
   Soumyarani VS, 2012, MOL CELL BIOCHEM, V366, P277, DOI 10.1007/s11010-012-1306-y
   Tayebjee MH, 2004, AM J HYPERTENS, V17, P770, DOI 10.1016/j.amjhyper.2004.06.023
   Uemura S, 2001, CIRC RES, V88, P1291, DOI 10.1161/hh1201.092042
   Viappiani S, 2009, BIOCHEM PHARMACOL, V77, P826, DOI 10.1016/j.bcp.2008.11.004
   Weinberg JB, 1998, MOL MED, V4, P557, DOI 10.1007/BF03401758
   Xie ZL, 2004, J BIOL CHEM, V279, P39513, DOI 10.1074/jbc.M405844200
   Xu XP, 1999, CIRCULATION, V99, P993, DOI 10.1161/01.CIR.99.8.993
NR 60
TC 8
Z9 8
U1 0
U2 2
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2014
VL 2014
AR 510619
DI 10.1155/2014/510619
PG 7
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA AL5ZY
UT WOS:000339213100001
PM 25114377
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Stellato, D
   Morrone, LF
   Di Giorgio, C
   Gesualdo, L
AF Stellato, Davide
   Morrone, Luigi Francesco
   Di Giorgio, Chiara
   Gesualdo, Loreto
TI Uric acid: a starring role in the intricate scenario of metabolic
   syndrome with cardio-renal damage?
SO INTERNAL AND EMERGENCY MEDICINE
LA English
DT Review
DE Uric acid; Oxidative stress; Endothelial disfunction; Inflammatory
   response
ID CHRONIC KIDNEY-DISEASE; BLOOD-PRESSURE; RISK-FACTOR; HYPERURICEMIA;
   HYPERTENSION; OBESITY
AB Elevated uric acid levels are a common finding in patients with metabolic syndrome and in those with cardiovascular and renal disease, but the meaning of this elevation is still unclear. In patients with chronic kidney diseases, it could merely reflect the reduction in glomerular filtration rate: but uric acid levels are known to be elevated in people, also in younger ones, prior to the development of hypertension or renal disease, independently of several risk factors. Multiple potential mechanisms suggest a causative role for uric acid in vascular disease. Uric acid has been shown to be involved in metabolic pathways that lead to oxidative stress, endothelial disfunction, and to a vascular and systemic inflammatory response. Moreover, the elevation in uric acid levels observed after fructose ingestion, with a consequent reduction in nitric oxide, may lead to a reduced glucose uptake in the skeletal muscle, hyperinsulinemia, and insulin resistance. Besides these bench research data, also clinical studies showed the beneficial effects of lowering uric acid therapies on several markers of cardiovascular and renal disease. To date, however, there is no evidence indicating that such therapies, that are not free of risk, may reduce cardiovascular events; so that to manage our prescriptions, we need larger, prospective, interventional data.
C1 [Di Giorgio, Chiara; Gesualdo, Loreto] Azienda Osped Univ OO RR, Foggia, Italy.
   [Stellato, Davide; Morrone, Luigi Francesco] Azienda Osped Rummo, Benevento, Italy.
RP Gesualdo, L (corresponding author), Azienda Osped Univ OO RR, Foggia, Italy.
EM l.gesualdo@altanet.it
RI MORRONE, Luigi Francesco Pio/ACH-0379-2022; Gesualdo, Loreto/K-7751-2016
OI MORRONE, Luigi Francesco Pio/0000-0002-1126-0719; Gesualdo,
   Loreto/0000-0002-4861-0911
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   AMES BN, 1981, P NATL ACAD SCI-BIOL, V78, P6858, DOI 10.1073/pnas.78.11.6858
   Bos MJ, 2006, STROKE, V37, P1503, DOI 10.1161/01.STR.0000221716.55088.d4
   CANNON PJ, 1966, NEW ENGL J MED, V275, P457, DOI 10.1056/NEJM196609012750902
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Eknoyan G, 2002, AM J KIDNEY DIS, V39, pS14, DOI 10.1053/ajkd.2002.30939
   Feig DI, 2008, NEW ENGL J MED, V359, P1811, DOI 10.1056/NEJMra0800885
   Feig DI, 2006, J AM SOC NEPHROL, V17, pS69, DOI 10.1681/ASN.2005121331
   Feig DI, 2006, CURR HYPERTENS REP, V8, P111, DOI 10.1007/s11906-006-0005-z
   Feig DI, 2003, HYPERTENSION, V42, P247, DOI 10.1161/01.HYP.0000085858.66548.59
   GERTLER MM, 1951, ANN INTERN MED, V34, P1421, DOI 10.7326/0003-4819-34-6-1421
   Gertzberg N, 2004, AM J PHYSIOL-LUNG C, V286, pL37, DOI 10.1152/ajplung.00116.2003
   Goicoechea M, 2010, CLIN J AM SOC NEPHRO, V5, P1388, DOI 10.2215/CJN.01580210
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   HALLFRISCH J, 1990, FASEB J, V4, P2652, DOI 10.1096/fasebj.4.9.2189777
   Heinig M, 2006, CLEV CLIN J MED, V73, P1059, DOI 10.3949/ccjm.73.12.1059
   HIGGINS P, 2009, CARDIOVASC PSYCHIAT, P82059
   Iseki K, 2008, J NEPHROL, V21, P305
   Mazzali M, 2001, HYPERTENSION, V38, P1101, DOI 10.1161/hy1101.092839
   Mazzali M, 2002, AM J PHYSIOL-RENAL, V282, pF991, DOI 10.1152/ajprenal.00283.2001
   Nakagawa T, 2008, INTERN EMERG MED, V3, P313, DOI 10.1007/s11739-008-0141-3
   Noman A, 2010, LANCET, V375, P2161, DOI 10.1016/S0140-6736(10)60391-1
   Obermayr RP, 2008, NEPHROL DIAL TRANSPL, V23, P1265, DOI 10.1093/ndt/gfm790
   Ramirez SPB, 2002, J AM SOC NEPHROL, V13, P1907, DOI 10.1097/01.ASN.0000018406.20282.C8
   Sarafidis PA, 2007, J CLIN ENDOCR METAB, V92, P379, DOI 10.1210/jc.2006-1819
   Sautin YY, 2008, NUCLEOS NUCLEOT NUCL, V27, P608, DOI 10.1080/15257770802138558
   Sautin YY, 2007, AM J PHYSIOL-CELL PH, V293, pC584, DOI 10.1152/ajpcell.00600.2006
   So A, 2010, J CLIN INVEST, V120, P1791, DOI 10.1172/JCI42344
   terMaaten JC, 1997, CLIN SCI, V92, P51
   Thatcher S, 2009, MOL CELL ENDOCRINOL, V302, P111, DOI 10.1016/j.mce.2009.01.019
   Tozawa M, 2002, KIDNEY INT, V62, P956, DOI 10.1046/j.1523-1755.2002.00506.x
   Trayhurn P, 2005, ACTA PHYSIOL SCAND, V184, P285, DOI 10.1111/j.1365-201X.2005.01468.x
   Viazzi F, 2011, DIABETES CARE, V34, P126, DOI 10.2337/dc10-0918
   Wahba IM, 2007, CLIN J AM SOC NEPHRO, V2, P550, DOI 10.2215/CJN.04071206
   Weiner DE, 2008, J AM SOC NEPHROL, V19, P1204, DOI 10.1681/ASN.2007101075
   World Health Organization, 1999, DIABETIC MED, V15, P539
NR 36
TC 18
Z9 18
U1 0
U2 10
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1828-0447
EI 1970-9366
J9 INTERN EMERG MED
JI Intern. Emerg. Med.
PD FEB
PY 2012
VL 7
IS 1
BP 5
EP 8
DI 10.1007/s11739-011-0642-3
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 881WO
UT WOS:000299522300003
PM 21842242
DA 2025-06-11
ER

PT J
AU Chellappan, D
   Joseph, J
   Shabi, MM
   Krishnamoorthy, G
   Ravindhran, D
   Uthrapathy, S
   Rajamanickam, VG
   Dubey, GP
AF Chellappan, Davidraj
   Joseph, Jipnomon
   Shabi, Mohamed M.
   Krishnamoorthy, Gayathri
   Ravindhran, Dhevi
   Uthrapathy, Subashini
   Rajamanickam, Victor G.
   Dubey, Govindha P.
TI Psycho-emotional stress - A cause of coronary artery disease
SO ACTA SCIENTIAE VETERINARIAE
LA English
DT Article
DE Lipid Profile; Oxidative Stress; Hung Stress; Rabbit; Lipid Peroxidation
ID LOW-DENSITY-LIPOPROTEIN; LIPID-PEROXIDATION; GLUTATHIONE-PEROXIDASE;
   CELL-DAMAGE; RESTRAINT; PLASMA; ASSAY
AB Psycho-emotional stress is one of the risk factors for metabolic syndrome and related diseases. Hence, this study has designed to the effect of psycho-emotional stress in the form of immobilization stress in rabbits. In this study, we used 12 male New Zealand White rabbits (2.5-3 kg body weight), Six animals for hanging fixation and another six as control. Blood samples were taken before hanging (0 minute) and at 60, 120 minutes. Serum was separated and used for the estimation of various biochemical parameters. Hanging fixation appears to produce significant increase in malondialdehyde and lipid profile levels. The non-enzymatic antioxidants like reduced glutathione, vitamin E and ceruloplasmin were found to be decrease and the level of enzymatic antioxidant like glutathione peroxidase was increased significantly. The results reveal that the hanging fixation may develop coronary artery disease. This is the area, which should be evaluated further by carrying out chronic studies in hung stress and by histopathological studies.
C1 [Chellappan, Davidraj; Joseph, Jipnomon; Shabi, Mohamed M.; Krishnamoorthy, Gayathri; Ravindhran, Dhevi; Uthrapathy, Subashini; Rajamanickam, Victor G.; Dubey, Govindha P.] SASTRA Univ, Ctr Adv Res Indian Syst Med, Thanjavur, India.
C3 Shanmugha Arts, Science, Technology & Research Academy (SASTRA)
RP Rajamanickam, VG (corresponding author), SASTRA Univ, Ctr Adv Res Indian Syst Med, Thanjavur, India.
EM vrajamanickam@yahoo.com
RI Chellappan, David/AAN-1373-2020; Uthirapathy, Subasini/L-6097-2017
CR ANDO M, 1994, J THERM BIOL, V19, P177, DOI 10.1016/0306-4565(94)90029-9
   [Anonymous], METHODS ENZYMOLOGY
   Arakawa H, 1997, J PHARMACOL EXP THER, V280, P1296
   AXELROD J, 1984, SCIENCE, V224, P452, DOI 10.1126/science.6143403
   BUCHANAN DC, 1974, PHYSIOL BEHAV, V13, P583, DOI 10.1016/0031-9384(74)90291-1
   GORDON DJ, 1989, NEW ENGL J MED, V321, P1311
   GUTTERIDGE JMC, 1995, CLIN CHEM, V41, P1819
   HABERLAND ME, 1988, SCIENCE, V241, P215, DOI 10.1126/science.2455346
   HALLIWELL B, 1984, LANCET, V1, P1396
   Hemnani T, 1998, Indian J Physiol Pharmacol, V42, P440
   IZUKA Y, 1992, NIPPON YAKURIGAKU ZA, V100, P151
   JIANG ZY, 1992, ANAL BIOCHEM, V202, P384, DOI 10.1016/0003-2697(92)90122-N
   JONSSON L, 1974, VIRCHOWS ARCH B, V17, P1
   Karthikeyan J., 2003, Indian Journal of Experimental Biology, V41, P135
   Kopin IJ, 1995, ANN NY ACAD SCI, V771, P19, DOI 10.1111/j.1749-6632.1995.tb44667.x
   Kovacs P, 1996, PHARMAZIE, V51, P51
   Lata Hem, 2002, Indian J Physiol Pharmacol, V46, P371
   Lekse J, 2001, MOL CELL BIOCHEM, V226, P89, DOI 10.1023/A:1012741903996
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   PALINSKI W, 1989, P NATL ACAD SCI USA, V86, P1372, DOI 10.1073/pnas.86.4.1372
   RAVIN HA, 1961, J LAB CLIN MED, V58, P161
   ROTRUCK JT, 1973, SCIENCE, V179, P588, DOI 10.1126/science.179.4073.588
   Sarov G. M., 2005, Bulgarian Journal of Veterinary Medicine, V8, P157
   Segal P., 1984, Clinical Diagnosis and Management, P180
   SEVANIAN A, 1985, ANNU REV NUTR, V5, P365, DOI 10.1146/annurev.nu.05.070185.002053
   Singhal Sangeeta, 1997, Indian Journal of Physiology and Allied Sciences, V51, P138
   Sun JS, 1999, FREE RADICAL RES, V31, P9, DOI 10.1080/10715769900300561
   SWANER JC, 1975, AM J PHYSIOL, V229, P365, DOI 10.1152/ajplegacy.1975.229.2.365
   YAGI K, 1987, CHEM PHYS LIPIDS, V45, P337, DOI 10.1016/0009-3084(87)90071-5
   YU BP, 1994, PHYSIOL REV, V74, P139, DOI 10.1152/physrev.1994.74.1.139
NR 30
TC 1
Z9 1
U1 0
U2 0
PU UNIV FED RIO GRANDE DO SUL
PI PORTO ALEGRE RS
PA FAC VET, CAIXA POSTAL 15017, PORTO ALEGRE RS, 91501-570, BRAZIL
SN 1678-0345
EI 1679-9216
J9 ACTA SCI VET
JI Acta Sci. Vet.
PY 2008
VL 36
IS 2
BP 133
EP 139
PG 7
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 470ZV
UT WOS:000268022100007
DA 2025-06-11
ER

PT J
AU Sodhi, K
   Srikanthan, K
   Goguet-Rubio, P
   Nichols, A
   Nawab, A
   Shah, PT
   Chaudhry, M
   El-Hamdani, M
   Xie, ZJ
   Shapiro, JI
AF Sodhi, Komal
   Srikanthan, Krithika
   Goguet-Rubio, Perrine
   Nichols, Alexandra
   Nawab, Athar
   Shah, Preeya T.
   Chaudhry, Muhammad
   El-Hamdani, Mehiar
   Xie, Zijian
   Shapiro, Joseph I.
TI Inhibition of Na/K-ATPase signaling attenuates steatohepatitis and
   atherosclerosis in mice fed a western diet
SO CELLULAR AND MOLECULAR BIOLOGY
LA English
DT Article
DE Na; K-ATPase signaling; obesity; oxidative stress; inflammation;
   steatohepatitis; atherosclerosis
ID FATTY LIVER-DISEASE; OXIDATIVE STRESS; METABOLIC SYNDROME; HEPATIC
   STEATOSIS; GENE-EXPRESSION; NA+/K+-ATPASE; PATHOGENESIS; IDENTIFICATION;
   INVOLVEMENT; FIBROSIS
AB We have previously reported that the alpha 1 subunit of sodium-potassium adenosine triphosphatase (Na/K-ATPase), acts as a receptor and an amplifier for reactive oxygen species, in addition to its distinct pumping function. On this background, we speculated that the blockade of Na/K-ATPase-induced ROS amplification with a specific peptide, pNaKtide, might attenuate the development of steatohepatitis. To test this hypothesis, pNaKtide was administered to a murine model of NASH: the C57Bl6 mouse fed a "western" diet containing high amounts of fat and fructose. The administration of pNaKtide reduced obesity as well as hepatic steatosis, inflammation and fibrosis. Of interest, we also noted a marked improvement in mitochondrial fatty acid oxidation, insulin sensitivity, dyslipidemia and aortic streaking in this mouse model. To further elucidate the effects of pNaKtide on atherosclerosis, similar studies were performed in ApoE knockout mice also exposed to the western diet. In these mice, pNaKtide not only improved steatohepatitis, dyslipidemia, and insulin sensitivity but also ameliorated significant aortic atherosclerosis. Collectively, this study demonstrates that the Na/K-ATPase/ROS amplification loop contributes significantly to the development and progression of steatohepatitis and atherosclerosis. Furthermore, this study presents a potential treatment, the pNaKtide, for the metabolic syndrome phenotype.
C1 [Sodhi, Komal; Srikanthan, Krithika; Goguet-Rubio, Perrine; Nichols, Alexandra; Nawab, Athar; Shah, Preeya T.; Chaudhry, Muhammad; El-Hamdani, Mehiar; Xie, Zijian; Shapiro, Joseph I.] Marshall Univ, Joan C Edwards Sch Med, Dept Med Surg & Cardiol, Huntington, WV 25755 USA.
C3 Marshall University
RP Sodhi, K (corresponding author), Marshall Univ, Joan C Edwards Sch Med, Dept Med Surg & Cardiol, Huntington, WV 25755 USA.
EM sodhi@marshall.edu
FU National Institutes of Health [HL109015, HL071556, HL105649]; Brick
   street Foundation; Huntington Foundation, Inc.
FX Acknowledgements This work was supported by National Institutes of
   Health Grants HL109015 (to J.I.S. and Z.X.) , HL071556 and HL105649 (to
   J.I.S.) , by the Brick street Foundation (to J.I.S.) and by the
   Huntington Foundation, Inc.
CR Ahn J, 2012, MOL NUTR FOOD RES, V56, P1665, DOI 10.1002/mnfr.201200182
   Boden G, 1997, DIABETES, V46, P3, DOI 10.2337/diabetes.46.1.3
   Bogacka I, 2005, DIABETES, V54, P1392, DOI 10.2337/diabetes.54.5.1392
   Browning JD, 2004, J CLIN INVEST, V114, P147, DOI 10.1172/JCI200422422
   Dowman JK, 2010, QJM-INT J MED, V103, P71, DOI 10.1093/qjmed/hcp158
   Haas JT, 2016, ANNU REV PHYSIOL, V78, P181, DOI 10.1146/annurev-physiol-021115-105331
   Haller ST, 2012, AM J HYPERTENS, V25, P690, DOI 10.1038/ajh.2012.17
   Inaba T, 2008, HYPERTENS RES, V31, P999, DOI 10.1291/hypres.31.999
   Kanwar P, 2016, CLIN LIVER DIS, V20, P225, DOI 10.1016/j.cld.2015.10.002
   Kennedy AJ, 2010, DIS MODEL MECH, V3, P156, DOI 10.1242/dmm.003467
   Kennedy DJ, 2008, AM J PHYSIOL-RENAL, V294, pF450, DOI 10.1152/ajprenal.00472.2007
   Kennedy DJ, 2013, HYPERTENSION, V61, P216, DOI 10.1161/HYPERTENSIONAHA.112.198770
   Kim E, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/290104
   Kohjima M, 2007, INT J MOL MED, V20, P351
   Lai FF, 2013, J BIOL CHEM, V288, P13295, DOI 10.1074/jbc.M113.467381
   Lalloyer F, 2011, ARTERIOSCL THROM VAS, V31, P1573, DOI 10.1161/ATVBAHA.110.220525
   Lanthier N, 2015, WORLD J HEPATOL, V7, P2184, DOI 10.4254/wjh.v7.i19.2184
   Li HG, 2014, ATHEROSCLEROSIS, V237, P208, DOI 10.1016/j.atherosclerosis.2014.09.001
   Li ZC, 2011, J BIOL CHEM, V286, P32394, DOI 10.1074/jbc.M110.207597
   Li ZC, 2009, J BIOL CHEM, V284, P21066, DOI 10.1074/jbc.M109.013821
   Liang M, 2007, J BIOL CHEM, V282, P10585, DOI 10.1074/jbc.M609181200
   Lim JS, 2010, NAT REV GASTRO HEPAT, V7, P251, DOI 10.1038/nrgastro.2010.41
   Liu J, 2000, J BIOL CHEM, V275, P27838
   Liu J, 2012, INT J NEPHROL, V2012, DOI 10.1155/2012/381320
   Machado MV, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0127991
   Mitsuyoshi Hironori, 2006, Nihon Rinsho, V64, P1077
   Nakamuta M, 2005, INT J MOL MED, V16, P631
   Nassir F, 2014, INT J MOL SCI, V15, P8713, DOI 10.3390/ijms15058713
   Polimeni L, 2015, WORLD J HEPATOL, V7, P1325, DOI 10.4254/wjh.v7.i10.1325
   Ritchie SA, 2007, NUTR METAB CARDIOVAS, V17, P319, DOI 10.1016/j.numecd.2006.07.005
   Rogge MM, 2009, BIOL RES NURS, V10, P356, DOI 10.1177/1099800408329408
   Schierwagen R, 2015, SCI REP-UK, V5, DOI 10.1038/srep12931
   Srikanthan K, 2016, INT J MED SCI, V13, P25, DOI 10.7150/ijms.13800
   Sumida Y, 2013, FREE RADICAL RES, V47, P869, DOI 10.3109/10715762.2013.837577
   Tacer KF, 2011, J LIPIDS, V2011, DOI 10.1155/2011/783976
   Tarantino G, 2013, WORLD J GASTROENTERO, V19, P6735, DOI 10.3748/wjg.v19.i40.6735
   Tsao CW, 2022, CIRCULATION, V145, pE153, DOI 10.1161/CIR.0000000000001052
   Verma S, 2013, LIVER INT, V33, P1398, DOI 10.1111/liv.12226
   Virani SS, 2021, CIRCULATION, V143, pe254, DOI 10.1161/CIR.0000000000000950
   Vogiatzi G, 2009, HELL J CARDIOL, V50, P402
   WAHREN J, 1984, J CLIN INVEST, V73, P1367, DOI 10.1172/JCI111340
   Xie ZJ, 1999, J BIOL CHEM, V274, P19323, DOI 10.1074/jbc.274.27.19323
   Yan YL, 2013, J BIOL CHEM, V288, P34249, DOI 10.1074/jbc.M113.461020
   Yan YL, 2012, MOL CELL BIOCHEM, V367, P175, DOI 10.1007/s11010-012-1331-x
   Zou X, 2014, ANTIOXID REDOX SIGN, V21, P1557, DOI 10.1089/ars.2013.5538
NR 45
TC 0
Z9 0
U1 1
U2 2
PU C M B  ASSOC
PI POITIERS
PA 34 BOULEVARD SOLFERINO, 86000 POITIERS, FRANCE
SN 0145-5680
EI 1165-158X
J9 CELL MOL BIOL
JI Cell. Mol. Biol.
PY 2023
VL 69
IS 2
BP 162
EP 171
DI 10.14715/cmb/2023.69.2.27
PG 10
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA J6IB5
UT WOS:001010619600027
PM 37224028
OA hybrid
DA 2025-06-11
ER

PT J
AU Zapata, RC
   Nasamran, CA
   Chilin-Fuentes, DR
   Dulawa, SC
   Osborn, O
AF Zapata, Rizaldy C. C.
   Nasamran, Chanond A. A.
   Chilin-Fuentes, Daisy R. R.
   Dulawa, Stephanie C. C.
   Osborn, Olivia
TI Identification of adipose tissue transcriptomic memory of anorexia
   nervosa
SO MOLECULAR MEDICINE
LA English
DT Article
DE Anorexia nervosa; Undernutrition; Transcriptomic memory; Adipose tissue;
   Calm2; Vps13d
ID EXPERIMENTAL WEIGHT PERTURBATION; MUSCLE WORK EFFICIENCY;
   SKELETAL-MUSCLE; INSULIN-RESISTANCE; METABOLIC SYNDROME; LEPTIN LEVELS;
   FOOD-INTAKE; OBESITY; ENERGY; GAIN
AB BackgroundAnorexia nervosa (AN) is a complex debilitating disease characterized by intense fear of weight gain and excessive exercise. It is the deadliest of any psychiatric disorder with a high rate of recidivism, yet its pathophysiology is unclear. The Activity-Based Anorexia (ABA) paradigm is a widely accepted mouse model of AN that recapitulates hypophagia and hyperactivity despite reduced body weight, however, not the chronicity.MethodsHere, we modified the prototypical ABA paradigm to increase the time to lose 25% of baseline body weight from less than 7 days to more than 2 weeks. We used this paradigm to identify persistently altered genes after weight restoration that represent a transcriptomic memory of under-nutrition and may contribute to AN relapse using RNA sequencing. We focused on adipose tissue as it was identified as a major location of transcriptomic memory of over-nutririon.ResultsWe identified 300 dysregulated genes that were refractory to weight restroration after ABA, including Calm2 and Vps13d, which could be potential global regulators of transcriptomic memory in both chronic over- and under-nutrition.ConclusionWe demonstrated the presence of peristent changes in the adipose tissue transcriptome in the ABA mice after weight restoration. Despite being on the opposite spectrum of weight perturbations, majority of the transcriptomic memory genes of under- and over-nutrition did not overlap, suggestive of the different mechanisms involved in these extreme nutritional statuses.
C1 [Zapata, Rizaldy C. C.; Osborn, Olivia] Univ Calif San Diego, Sch Med, Div Endocrinol & Metab, San Diego, CA 92093 USA.
   [Nasamran, Chanond A. A.; Chilin-Fuentes, Daisy R. R.] Univ Calif San Diego, Ctr Computat Biol & Bioinformat, Sch Med, San Diego, CA USA.
   [Dulawa, Stephanie C. C.] Univ Calif San Diego, Sch Med, Dept Psychiat, San Diego, CA 92093 USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego
RP Zapata, RC (corresponding author), Univ Calif San Diego, Sch Med, Div Endocrinol & Metab, San Diego, CA 92093 USA.
EM rczapata@health.ucsd.edu
RI osborn, olivia/R-1460-2018
OI Zapata, Rizaldy/0000-0003-4745-8513
CR Abete I, 2006, NUTR RES REV, V19, P5, DOI 10.1079/NRR2006112
   Martínez JA, 2014, ADV NUTR, V5, P71, DOI 10.3945/an.113.004705
   Balthasar N, 2004, NEURON, V42, P983, DOI 10.1016/j.neuron.2004.06.004
   Beeler JA, 2021, BIOL PSYCHIAT, V90, P829, DOI 10.1016/j.biopsych.2020.06.030
   Berends T, 2016, BMC PSYCHIATRY, V16, DOI 10.1186/s12888-016-1019-y
   Braun JL, 2020, FASEB BIOADV, V2, P579, DOI 10.1096/fba.2020-00052
   Bulló M, 2007, EUR J ENDOCRINOL, V157, P303, DOI 10.1530/EJE-06-0716
   Carter JC, 2012, PSYCHIAT RES, V200, P518, DOI 10.1016/j.psychres.2012.04.037
   Caslin HL, 2020, IMMUNOL REV, V295, P101, DOI 10.1111/imr.12853
   Choe SS, 2016, FRONT ENDOCRINOL, V7, DOI 10.3389/fendo.2016.00030
   Choi S, 2021, DIABETES, V70, P1664, DOI 10.2337/db20-1050
   Daimon CM, 2022, AM J PHYSIOL-REG I, V322, pR219, DOI 10.1152/ajpregu.00313.2021
   Doucet E, 2000, INT J OBESITY, V24, P906, DOI 10.1038/sj.ijo.0801251
   Duncan L, 2017, AM J PSYCHIAT, V174, P850, DOI 10.1176/appi.ajp.2017.16121402
   Ellis JM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0116587
   EPSTEIN PN, 1989, CELL, V58, P1067, DOI 10.1016/0092-8674(89)90505-9
   Fischer IP, 2018, INT J OBESITY, V42, P507, DOI 10.1038/ijo.2017.224
   Foldi CJ, 2021, PROG NEURO-PSYCHOPH, V111, DOI 10.1016/j.pnpbp.2021.110395
   Gao H, 2022, NUTRIENTS, V14
   Geyer PE, 2016, MOL SYST BIOL, V12, DOI 10.15252/msb.20167357
   Goldsmith R, 2010, AM J PHYSIOL-REG I, V298, pR79, DOI 10.1152/ajpregu.00053.2009
   Gupta A, 2020, NAT REV GASTRO HEPAT, V17, P655, DOI 10.1038/s41575-020-0341-5
   Hahn O, 2019, NAT METAB, V1, P1059, DOI 10.1038/s42255-019-0121-0
   Hauffe R, 2020, JCI INSIGHT, V5, DOI 10.1172/jci.insight.136283
   Heintz MM, 2019, J NUTR BIOCHEM, V70, P125, DOI 10.1016/j.jnutbio.2019.05.004
   Hernandez-Carretero A, 2018, INT J OBESITY, V42, P728, DOI 10.1038/ijo.2017.266
   Ho EV, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0166756
   Holtkamp K, 2004, PSYCHONEUROENDOCRINO, V29, P791, DOI 10.1016/S0306-4530(03)00143-4
   Holtkamp K, 2003, J PSYCHIATR RES, V37, P165, DOI 10.1016/S0022-3956(02)00100-0
   Huang XH, 2012, BIOL OPEN, V1, P705, DOI 10.1242/bio.20121875
   Jiang SM, 2015, J HEPATOL, V62, P371, DOI 10.1016/j.jhep.2014.09.026
   Kang SJ, 2018, NAT IMMUNOL, V19, P561, DOI 10.1038/s41590-018-0108-0
   Kolehmainen J, 2004, AM J HUM GENET, V75, P122, DOI 10.1086/422197
   Li B, 2014, INT J OBESITY, V38, P192, DOI 10.1038/ijo.2013.86
   Li PP, 2010, J BIOL CHEM, V285, P15333, DOI 10.1074/jbc.M110.100263
   Li XY, 2022, INT J MED SCI, V19, P1442, DOI 10.7150/ijms.74335
   Liao CY, 2021, J GERONTOL A-BIOL, V76, P1714, DOI 10.1093/gerona/glab145
   Lumeng CN, 2007, DIABETES, V56, P16, DOI 10.2337/db06-1076
   Matsubara M, 2002, EUR J ENDOCRINOL, V147, P173, DOI 10.1530/eje.0.1470173
   Mayer L, 2005, AM J CLIN NUTR, V81, P1286
   Mayer LES, 2009, AM J CLIN NUTR, V90, P1132, DOI 10.3945/ajcn.2009.27820
   McDonough W, 2020, FASEB J, V34, P12533, DOI 10.1096/fj.202001016RR
   Miletta MC, 2020, NAT METAB, V2, P1204, DOI 10.1038/s42255-020-00300-8
   Millership SJ, 2018, MOL METAB, V18, P97, DOI 10.1016/j.molmet.2018.09.001
   Molocea CE, 2020, CURR OPIN PHARMACOL, V53, P101, DOI 10.1016/j.coph.2020.07.006
   Pike KM, 1998, CLIN PSYCHOL REV, V18, P447, DOI 10.1016/S0272-7358(98)00014-2
   Robinette TM, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-16348-9
   Rosenbaum M, 2003, AM J PHYSIOL-REG I, V285, pR183, DOI 10.1152/ajpregu.00474.2002
   Rosenbaum M, 2005, J CLIN INVEST, V115, P3579, DOI 10.1172/JCI25977
   Rossi MA, 2018, CELL METAB, V27, P42, DOI 10.1016/j.cmet.2017.09.021
   Schalla MA, 2019, FRONT NUTR, V6, DOI 10.3389/fnut.2019.00069
   Schmitz J, 2016, MOL METAB, V5, P328, DOI 10.1016/j.molmet.2015.12.001
   Shimano H, 2009, FEBS J, V276, P616, DOI 10.1111/j.1742-4658.2008.06806.x
   Speakman JR, 2011, DIS MODEL MECH, V4, P733, DOI 10.1242/dmm.008698
   Sumithran P, 2011, NEW ENGL J MED, V365, P1597, DOI 10.1056/NEJMoa1105816
   Sun Y, 2016, DIABETES, V65, P1630, DOI 10.2337/db15-1193
   Thaiss CA, 2016, NATURE, V540, P544, DOI 10.1038/nature20796
   Torres-Fuentes C, 2017, LANCET GASTROENTEROL, V2, P747, DOI 10.1016/S2468-1253(17)30147-4
   Ueki K, 2004, P NATL ACAD SCI USA, V101, P10422, DOI 10.1073/pnas.0402511101
   Unal R, 2010, J CLIN ENDOCR METAB, V95, P2993, DOI 10.1210/jc.2009-2623
   van Eeden AE, 2021, CURR OPIN PSYCHIATR, V34, P515, DOI 10.1097/YCO.0000000000000739
   Watson HJ, 2019, NAT GENET, V51, P1207, DOI 10.1038/s41588-019-0439-2
   Welch AC, 2019, MOL PSYCHIATR
   Xiao Y, 2020, ADIPOCYTE, V9, P472, DOI 10.1080/21623945.2020.1803643
   Xu J, 2018, NATURE, V556, P505, DOI 10.1038/s41586-018-0049-7
   Yuzawa Y, 2008, J AM SOC NEPHROL, V19, P1701, DOI 10.1681/ASN.2006121358
   Zapata RC, 2022, NAT COMMUN, V13, DOI 10.1038/s41467-022-32764-5
   Zerwas S, 2011, PSYCHIAT ANN, V41, P532, DOI 10.3928/00485713-20111017-06
   Zhang J, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.711181
   Zhang ZZ, 2021, CELL METAB, V33, P1624, DOI 10.1016/j.cmet.2021.06.001
   Zhu XQ, 2017, MOL METAB, V6, P494, DOI 10.1016/j.molmet.2017.03.003
NR 71
TC 4
Z9 4
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1076-1551
EI 1528-3658
J9 MOL MED
JI Mol. Med.
PD AUG 15
PY 2023
VL 29
IS 1
AR 109
DI 10.1186/s10020-023-00705-7
PG 12
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
   Medicine
GA P1LR6
UT WOS:001048330300002
PM 37582711
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Oliva, ME
   Degrave, V
   Ingaramo, P
   Collins, P
   D'Alessandro, ME
AF Oliva, Maria Eugenia
   Degrave, Valentina
   Ingaramo, Paola
   Collins, Pablo
   D'Alessandro, Maria Eugenia
TI Effects of astaxanthin on the mechanisms involved in skeletal muscle
   lipid metabolism and oxidative stress in an experimental model of
   metabolic syndrome
SO FOOD & FUNCTION
LA English
DT Article; Early Access
ID INSULIN; LIPOGENESIS
AB This study aimed to evaluate the mechanisms involved in skeletal muscle lipotoxicity, impaired lipid metabolism, and oxidative stress induced by a sucrose-rich diet (SRD) that mimics human Metabolic Syndrome (MS), and to assess the preventive effects and molecular mechanisms of astaxanthin (AXT) extracted from freshwater crabs (Dilocarcinus pagei) on these alterations. Male Wistar rats received a reference diet (RD), RD + AXT, SRD, or SRD + AXT (10 mg kg-1 day-1 orally) for 90 days. Serum glucose, triglycerides, and cholesterol were measured. In skeletal muscle, triglyceride content, activities of lipogenic enzymes [fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC), malic enzyme (ME), glucose-6-phosphate dehydrogenase (G-6-PDH)] and mitochondrial beta-oxidation enzyme [carnitine palmitoyltransferase-1 (CPT-1)] were assessed, along with the expression of transcription factors sterol regulatory element binding protein-1c (SREBP-1c) and peroxisome proliferator-activated receptor-alpha (PPAR alpha) by qPCR. Oxidative stress was evaluated by reactive oxygen species (ROS), glutathione (GSH), and antioxidant enzymes (CAT, GPx, GR), as well as pNF kappa B p65 and NrF2 protein levels. SRD feeding induced dyslipidemia, intramuscular triglyceride accumulation, increased de novo lipogenesis and SREBP-1c expression, and reduced CPT-1 activity and PPAR alpha expression in skeletal muscle. Oxidative stress was evidenced by elevated ROS and decreased GSH and antioxidant enzyme activities, with reduced NrF2 and increased pNF kappa B p65 levels. AXT supplementation attenuated these alterations by downregulating lipogenic enzymes and SREBP-1c, enhancing CPT-1 and PPAR alpha expression, and modulating NrF2 and pNF kappa B p65, thus improving lipid metabolism and redox balance in skeletal muscle. This study revealed new aspects of skeletal muscle lipid accumulation, lipid metabolism, and oxidative stress in SRD-fed rats. We demonstrated the novel properties and molecular mechanisms of AXT extracted from freshwater crabs on these parameters in the skeletal muscle of an experimental model of MS.
C1 [Oliva, Maria Eugenia; Degrave, Valentina; D'Alessandro, Maria Eugenia] Univ Nacl Litoral, Fac Bioquim & Ciencias Biol, Lab Estudio Enfermedades Metab Relacionadas Nutr, Ciudad Univ,cc242, RA-3000 Santa Fe, Argentina.
   [Oliva, Maria Eugenia; D'Alessandro, Maria Eugenia] Consejo Nacl Invest Cient & Tecn CONICET, Santa Fe, Argentina.
   [Ingaramo, Paola] Consejo Nacl Invest Cient & Tecn CONICET, Inst Salud & Ambiente Litoral ISAL, Fac Bioquim & Ciencias Biol, Santa Fe, Argentina.
   [Collins, Pablo] FBCB UNL, Catedra Limnol, COE INTA Angel Gallardo EEA, Rafaela, Argentina.
C3 National University of the Littoral; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET)
RP D'Alessandro, ME (corresponding author), Univ Nacl Litoral, Fac Bioquim & Ciencias Biol, Lab Estudio Enfermedades Metab Relacionadas Nutr, Ciudad Univ,cc242, RA-3000 Santa Fe, Argentina.; D'Alessandro, ME (corresponding author), Consejo Nacl Invest Cient & Tecn CONICET, Santa Fe, Argentina.
EM medaless@fbcb.unl.edu.ar
RI Oliva, Maria/IUM-4089-2023
OI Oliva, Maria Eugenia/0000-0002-4368-4102
FU Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET),
   Argentina [PIP 2021-2023 GI 11220200101185CO]
FX This work was supported by Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET), Argentina [PIP 2021-2023 GI
   #11220200101185CO]. The authors would like to thank Candelaria Mauti for
   their skillful technical assistance.
CR Aldahhan Rashid Abdulhameed, 2022, J Med Life, V15, P1334, DOI 10.25122/jml-2022-0157
   Aoi W, 2008, BIOCHEM BIOPH RES CO, V366, P892, DOI 10.1016/j.bbrc.2007.12.019
   Arunkumar E, 2012, FOOD FUNCT, V3, P120, DOI 10.1039/c1fo10161g
   Bonnard C, 2008, J CLIN INVEST, V118, P789, DOI 10.1172/JCI32601
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Bruce KD, 2010, J NUTR, V140, P648, DOI 10.3945/jn.109.111179
   Calvo NS, 2020, ANIM FEED SCI TECH, V270, DOI 10.1016/j.anifeedsci.2020.114668
   Chen Y, 2024, NUTRIENTS, V16, DOI 10.3390/nu16010033
   Chesler KC, 2022, LAB ANIM-UK, V56, P147, DOI 10.1177/00236772211016926
   Chicco A, 2003, J NUTR, V133, P127, DOI 10.1093/jn/133.1.127
   D'Alessandro ME, 2006, NUTR RES, V26, P289, DOI 10.1016/j.nutres.2006.06.001
   del Campo A, 2023, CURR MED CHEM, V30, P3927, DOI 10.2174/0929867330666221209093343
   Ferreira MD, 2020, J FUNCT FOODS, V66, DOI 10.1016/j.jff.2019.103775
   Echeverría F, 2016, PROSTAG LEUKOTR ESS, V114, P28, DOI 10.1016/j.plefa.2016.10.001
   Rubio-Ruiz ME, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20030647
   D'Alessandro ME, 2015, FOOD FUNCT, V6, P1299, DOI [10.1039/c4fo00903g, 10.1039/C4FO00903G]
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   Funai K, 2013, J CLIN INVEST, V123, P1229, DOI 10.1172/JCI65726
   Gowd V, 2021, MOL NUTR FOOD RES, V65, DOI 10.1002/mnfr.202100252
   Guillet-Deniau I, 2004, J CELL SCI, V117, P1937, DOI 10.1242/jcs.01069
   Hsu KJ, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092163
   Illesca PG, 2025, BIOFACTORS, V51, DOI 10.1002/biof.2087
   Ingaramo PI, 2022, ENVIRON POLLUT, V296, DOI 10.1016/j.envpol.2021.118729
   Ingaramo PI, 2019, FOOD CHEM TOXICOL, V134, DOI 10.1016/j.fct.2019.110832
   Jaiswal N, 2015, FREE RADICAL RES, V49, P1055, DOI 10.3109/10715762.2015.1031662
   Joubert MBV, 2025, J NUTR BIOCHEM, V135, DOI 10.1016/j.jnutbio.2024.109779
   Li GS, 2016, EXP THER MED, V11, P2259, DOI 10.3892/etm.2016.3209
   Li W, 2021, BMC COMPLEMENT MED, V21, DOI 10.1186/s12906-020-03182-1
   Mengeste AM, 2021, OBESITY, V29, P1582, DOI 10.1002/oby.23227
   Mitrovic B, 2023, ARCH MED SCI, V19, P884, DOI 10.5114/aoms/150639
   Muoio Deborah M, 2007, Novartis Found Symp, V286, P24
   Nishi H, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071664
   Nishida Y, 2023, MAR DRUGS, V21, DOI 10.3390/md21100514
   Nishida Y, 2020, J CACHEXIA SARCOPENI, V11, P241, DOI 10.1002/jcsm.12530
   Pok PS, 2023, HELIYON, V9, DOI 10.1016/j.heliyon.2023.e17381
   REEVES PG, 1993, J NUTR, V123, P1939, DOI 10.1093/jn/123.11.1939
   Rossi AS, 2013, BRIT J NUTR, V109, P1617, DOI 10.1017/S0007114512003558
   Song A, 2014, INT J MOL MED, V33, P1671, DOI 10.3892/ijmm.2014.1738
   Sugden MC, 2006, FUTURE LIPIDOL, V1, P153, DOI 10.2217/17460875.1.2.153
   Tillmann S, 2018, BENEF MICROBES, V9, P311, DOI [10.3920/BM2017.0127, 10.3920/bm2017.0127]
   Turner PV, 2011, J AM ASSOC LAB ANIM, V50, P614
   Vargas MR, 2025, J NUTR BIOCHEM, V142, DOI 10.1016/j.jnutbio.2025.109924
   Joubert MBV, 2022, FOOD FUNCT, V13, P7333, DOI 10.1039/d2fo00642a
   Wang RW, 2020, J SPORT HEALTH SCI, V9, P211, DOI 10.1016/j.jshs.2019.09.008
   Wang Y, 2019, J NUTR BIOCHEM, V64, P182, DOI 10.1016/j.jnutbio.2018.10.021
   Wong SK, 2020, EXP THER MED, V20, P2941, DOI 10.3892/etm.2020.9075
   Yoshihara T., 2019, J. Phys. Fitness Sports Med, V8, P61, DOI DOI 10.7600/JPFSM.8.61
   Zhang BS, 2018, CYTA-J FOOD, V16, P909, DOI 10.1080/19476337.2018.1503617
NR 48
TC 0
Z9 0
U1 1
U2 1
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD 2025 MAY 20
PY 2025
DI 10.1039/d5fo02156a
EA MAY 2025
PG 11
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA 2WW3U
UT WOS:001493237400001
PM 40407785
DA 2025-06-11
ER

PT J
AU Aiello, A
   Di Bona, D
   Candore, G
   Carru, C
   Zinellu, A
   Di Miceli, G
   Nicosia, A
   Gambino, CM
   Ruisi, P
   Caruso, C
   Vasto, S
   Accardi, G
AF Aiello, Anna
   Di Bona, Danilo
   Candore, Giuseppina
   Carru, Ciriaco
   Zinellu, Angelo
   Di Miceli, Giuseppe
   Nicosia, Aldo
   Gambino, Caterina Maria
   Ruisi, Paolo
   Caruso, Calogero
   Vasto, Sonya
   Accardi, Giulia
TI Targeting Aging with Functional Food: Pasta with Opuntia
   Single-Arm Pilot Study
SO REJUVENATION RESEARCH
LA English
DT Article
DE age-related diseases; Mediterranean diet; nutrition; Opuntia Ficus
   Indica; oxidative stress
ID FICUS-INDICA; URIC-ACID; METABOLIC SYNDROME; OXIDATIVE STRESS;
   RISK-FACTORS; BODY-WEIGHT; CACTUS; ANTIOXIDANT; CLADODES; BLOOD
AB Interventions to extend life span represent the new perspective in aging investigation. Healthy dietary habits are important modifiable factors that can favor a healthy aging phenotype. Many studies have demonstrated benefits for metabolic syndrome and type 2 diabetes mellitus resulting from the traditional Mediterranean foods. Opuntia Ficus Indica (OFI), widespread in the Mediterranean basin, belongs to the Cactaceae family. It is known for its antioxidant and anti-inflammatory properties. Moreover, products containing extracts from OFI fruits or cladodes have been used to control obesity and other metabolic parameters, such as glycemia and lipid profile. The aim of this study was to analyze the antioxidant and anti-inflammatory effect of pasta with 3% of OFI cladode extracts added to show its beneficial effect in human health. We performed a single arm longitudinal intervention study in 42 healthy volunteers, administrating 500g/week of this functional pasta for 30 days. Our pasta had antioxidant and anti-inflammatory properties with putative effect on the aging process and related metabolic diseases. We also demonstrated a hypoglycemic effect. The results are preliminary, but it is possible to speculate that our pasta could be considered an effective food for the prevention of age-related metabolic disorders.
C1 [Aiello, Anna; Candore, Giuseppina; Gambino, Caterina Maria; Caruso, Calogero; Accardi, Giulia] Univ Palermo, Dept Pathobiol & Med Biotechnol, Corso Tukory 211, I-90134 Palermo, Italy.
   [Di Bona, Danilo] Univ Bari Aldo Moro, Dept Emergency & Organ Transplants, Bari, Italy.
   [Carru, Ciriaco; Zinellu, Angelo] Univ Sassari, Dept Biomed Sci, Sassari, Italy.
   [Di Miceli, Giuseppe; Ruisi, Paolo] Univ Palermo, Dept Agr & Forest Sci, Palermo, Italy.
   [Nicosia, Aldo] CNR, Lab Mol Ecol & Biotechnol, Inst Marine & Coastal Environm IAMC CNR, Detached Unit Capo Granitola, Trapani, Italy.
   [Vasto, Sonya] Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol, Palermo, Italy.
C3 University of Palermo; Universita degli Studi di Bari Aldo Moro;
   University of Sassari; University of Palermo; Consiglio Nazionale delle
   Ricerche (CNR); L'Istituto per l'Ambiente Marino Costiero (IAMC-CNR);
   University of Palermo
RP Caruso, C (corresponding author), Univ Palermo, Dept Pathobiol & Med Biotechnol, Corso Tukory 211, I-90134 Palermo, Italy.
EM calogero.caruso@unipa.it
RI GAMBINO, CATERINA/AAC-2871-2019; Carru, Ciriaco/AAI-9996-2021; accardi,
   giulia/K-3835-2018; Candore, Giuseppina/K-9496-2016; Di Miceli,
   Giuseppe/HZK-3174-2023; Nicosia, Aldo/R-4462-2017; Vasto,
   Sonya/I-4771-2013
OI Candore, Giuseppina/0000-0002-9966-934X; Accardi,
   Giulia/0000-0003-3565-9529; Nicosia, Aldo/0000-0002-1013-2862; Zinellu,
   Angelo/0000-0002-8396-0968; Vasto, Sonya/0000-0002-6033-4745; DI MICELI,
   Giuseppe/0000-0002-8076-5972; Carru, Ciriaco/0000-0002-6985-4907;
   Gambino, Caterina Maria/0000-0003-2937-3428
FU PON DI.ME.SA. (Programma Operativo Nazionale Ricerca e Competitivita)
   [PON02_00451_3361785]
FX The original work was supported by PON DI.ME.SA. (Programma Operativo
   Nazionale Ricerca e Competitivita) 2007/2013 - Progetto 'DI.ME.SA.'
   PON02_00451_3361785 (Valorization of Typical Products of the
   Mediterranean Diet and Their Nutraceutical Use to Improve Health) given
   to C.C. and G.C. The Institutional Ethics Committee (Policlinico Paolo
   Giaccone, University Hospital) approved the study protocol. The authors
   thank Antonella Plaia for her contribution to statistical analysis, and
   Marcello Tagliavia and Angela Cuttitta for their contribution to data
   collection.
CR Accardi G, 2016, IMMUN AGEING, V13, DOI 10.1186/s12979-016-0067-y
   Avery P, 2014, CURR VASC PHARMACOL, V12, P659, DOI 10.2174/1570161111666131219101226
   Bagnati M, 1999, BIOCHEM J, V340, P143, DOI 10.1042/0264-6021:3400143
   Barera A, 2016, IMMUN AGEING, V13, DOI 10.1186/s12979-016-0068-x
   BIONAP srl, 2017, BIOACT NAT PROD
   Biswas S, 2006, BIOCHEM PHARMACOL, V71, P551, DOI 10.1016/j.bcp.2005.10.044
   Bourdon E, 2001, ANTIOXID REDOX SIGN, V3, P293, DOI 10.1089/152308601300185241
   Buscemi S, 2013, EUR J CLIN NUTR, V67, P1284, DOI 10.1038/ejcn.2013.172
   Camps J, 2009, CRIT REV CL LAB SCI, V46, P83, DOI 10.1080/10408360802610878
   Chianetta R, 2017, PHARMANUTR FUNCT FOO, P42
   Dato S, 2013, INT J MOL SCI, V14, P16443, DOI 10.3390/ijms140816443
   Di Lorenzo F, 2017, CARBOHYD POLYM, V157, P128, DOI 10.1016/j.carbpol.2016.09.073
   Durazzo A, 2017, FOODS, V6, DOI 10.3390/foods6030017
   El-Mostafa K, 2014, MOLECULES, V19, P14879, DOI 10.3390/molecules190914879
   Elks CM, 2010, CURR HYPERTENS REP, V12, P99, DOI 10.1007/s11906-010-0096-4
   ELLMAN GL, 1959, ARCH BIOCHEM BIOPHYS, V82, P70, DOI 10.1016/0003-9861(59)90090-6
   Farah R, 2016, EXP CLIN ENDOCR DIAB, V124, P568, DOI 10.1055/s-0042-113125
   Feugang JM, 2006, FRONT BIOSCI-LANDMRK, V11, P2574, DOI 10.2741/1992
   GAN KN, 1991, DRUG METAB DISPOS, V19, P100
   Ginestra G, 2009, J AGR FOOD CHEM, V57, P10323, DOI 10.1021/jf9022096
   Ginsberg Henry N, 2009, J Cardiometab Syndr, V4, P113, DOI 10.1111/j.1559-4572.2008.00044.x
   Giovinazzo G, 2015, PLANT FOOD HUM NUTR, V70, P454, DOI 10.1007/s11130-015-0518-1
   Glantzounis GK, 2005, CURR PHARM DESIGN, V11, P4145, DOI 10.2174/138161205774913255
   González-Rodríguez LG, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040326
   Hanson RL, 2002, DIABETES, V51, P3120, DOI 10.2337/diabetes.51.10.3120
   Hogg PJ, 2003, TRENDS BIOCHEM SCI, V28, P210, DOI 10.1016/S0968-0004(03)00057-4
   Hunt D.R., 2006, The New Cactus Lexicon
   Johnston KL, 2010, DIABETIC MED, V27, P391, DOI 10.1111/j.1464-5491.2010.02923.x
   Klatt P, 2000, EUR J BIOCHEM, V267, P4928, DOI 10.1046/j.1432-1327.2000.01601.x
   Koguchi T, 2002, J NUTR SCI VITAMINOL, V48, P184, DOI 10.3177/jnsv.48.184
   Laaksonen DE, 2002, AM J EPIDEMIOL, V156, P1070, DOI 10.1093/aje/kwf145
   Lee JC, 2002, J AGR FOOD CHEM, V50, P6490, DOI 10.1021/jf020388c
   Leem KH, 2016, NUTRIENTS, V8, DOI 10.3390/nu8120800
   Linarés E, 2007, ADV THER, V24, P1115, DOI 10.1007/BF02877717
   López-Romero P, 2014, J ACAD NUTR DIET, V114, P1811, DOI [10.1016/j.jand.2014.06., 10.1016/j.jand.2014.06.352]
   Marco ML, 2017, CURR OPIN BIOTECH, V44, P94, DOI 10.1016/j.copbio.2016.11.010
   Martinelli N, 2012, EXP DIABETES RES, DOI 10.1155/2012/231502
   Martirosyan DM, 2015, FUNCT FOODS HEALTH D, V5, P209
   Nuñez-López MA, 2013, J AGR FOOD CHEM, V61, P10981, DOI 10.1021/jf403834x
   Onakpoya IJ, 2015, NUTRITION, V31, P640, DOI 10.1016/j.nut.2014.11.015
   Ortega RM, 2006, PUBLIC HEALTH NUTR, V9, P1136, DOI 10.1017/S1368980007668530
   Osuna-Mart��nez U., 2014, Natural Products Chemistry and Research, V2, P1, DOI [10.4172/2329-6836.1000153, DOI 10.4172/2329-6836.1000153]
   Panico AM, 2007, J ETHNOPHARMACOL, V111, P315, DOI 10.1016/j.jep.2006.11.020
   Park EH, 1998, ARCH PHARM RES, V21, P30, DOI 10.1007/BF03216749
   Pasqualone A, 2016, FOOD CHEM, V213, P545, DOI 10.1016/j.foodchem.2016.07.006
   Post RE, 2012, J AM BOARD FAM MED, V25, P16, DOI 10.3122/jabfm.2012.01.110148
   Reboredo-Rodríguez P, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18030668
   Ros E, 2015, BRIT J NUTR, V113, pS111, DOI 10.1017/S0007114514003924
   Saenz C, 2000, J ARID ENVIRON, V46, P209, DOI 10.1006/jare.2000.0676
   Sautin YY, 2008, NUCLEOS NUCLEOT NUCL, V27, P608, DOI 10.1080/15257770802138558
   Sentí M, 2003, J CLIN ENDOCR METAB, V88, P5422, DOI 10.1210/jc.2003-030648
   Siriwardhana N, 2004, EUR FOOD RES TECHNOL, V219, P369, DOI 10.1007/s00217-004-0956-8
   Sotgia S, 2016, BIOANALYSIS, V8, P945, DOI 10.4155/bio-2015-0002
   Stintzing FC, 2005, MOL NUTR FOOD RES, V49, P175, DOI 10.1002/mnfr.200400071
   Strazzullo P, 2007, NUTR METAB CARDIOVAS, V17, P409, DOI 10.1016/j.numecd.2007.02.011
   Tesoriere L, 2005, J AGR FOOD CHEM, V53, P1266, DOI 10.1021/jf048134+
   Thiese MS, 2014, BIOCHEM MEDICA, V24, P199, DOI 10.11613/BM.2014.022
   Vasto S, 2018, REJUV RES, V21, P37, DOI 10.1089/rej.2017.1950
   Virruso C, 2014, REJUV RES, V17, P217, DOI 10.1089/rej.2013.1532
   Wang JQ, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/5692852
   Wilcox Gisela, 2005, Clin Biochem Rev, V26, P19
   Zhao MM, 2007, FOOD CHEM, V105, P1480, DOI 10.1016/j.foodchem.2007.05.031
NR 62
TC 15
Z9 15
U1 0
U2 18
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1549-1684
EI 1557-8577
J9 REJUV RES
JI Rejuv. Res.
PD JUN
PY 2018
VL 21
IS 3
BP 249
EP 256
DI 10.1089/rej.2017.1992
PG 8
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA GJ4DA
UT WOS:000435329000007
PM 28851251
DA 2025-06-11
ER

PT J
AU Lim, S
   Oh, TJ
   Koh, KK
AF Lim, Soo
   Oh, Tae Jung
   Koh, Kwang Kon
TI Mechanistic link between nonalcoholic fatty liver disease and
   cardiometabolic disorders
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Review
DE Non-alcoholic fatty liver disease; Insulin resistance; Inflammation;
   Oxidative stress; Gut microbiota; Cardiovascular disease;
   Atherosclerosis
ID GLYCATION END-PRODUCTS; INTESTINAL BACTERIAL OVERGROWTH; HEPATIC
   INSULIN-RESISTANCE; GAMMA-GLUTAMYL-TRANSFERASE; ACTIVATED
   PROTEIN-KINASE; C-REACTIVE PROTEIN; TERM-FOLLOW-UP; METABOLIC SYNDROME;
   ALANINE AMINOTRANSFERASE; CARDIOVASCULAR-DISEASE
AB Nonalcoholic fatty liver disease (NAFLD) is a chronic condition characterized by fat accumulation combined with low-grade inflammation in the liver. A large body of clinical and experimental data shows that increased flux of free fatty acids from increased visceral adipose tissue can lead to NAFLD related with insulin resistance. Thus, individuals with obesity, insulin resistance, and dyslipidemia are at the greatest risk of developing NAFLD. Conversely, NAFLD is one of the phenotypes of insulin resistance or metabolic syndrome. Many researchers have discovered a close association between NAFLD and insulin resistance, and focused on the role of NAFLD in the development of type 2 diabetes. Further, substantial evidence has suggested the association between NAFLD and cardiovascular disease (CVD). In the current review, we provide a plausible mechanistic link between NAFLD and CVD and the potential of the former as a therapeutic target based on pathophysiology. We also discuss in detail about the role of insulin resistance, oxidative stress, low-grade inflammation, abnormal lipid metabolism, gut microbiota, changes of biomarkers, and genetic predisposition in the pathological linking between NAFLD and cardiometabolic disorders. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Lim, Soo; Oh, Tae Jung] Seoul Natl Univ, Coll Med, Dept Internal Med, Songnam 463070, South Korea.
   [Lim, Soo; Oh, Tae Jung] Seoul Natl Univ, Bundang Hosp, Songnam 463070, South Korea.
   [Koh, Kwang Kon] Gachon Univ, Gil Med Ctr, Dept Cardiol, Inchon, South Korea.
   [Koh, Kwang Kon] Gachon Cardiovasc Res Inst, Inchon, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU); Gachon
   University; Gachon University
RP Lim, S (corresponding author), Seoul Natl Univ, Coll Med, Dept Internal Med, 300 Gumi Dong, Songnam 463070, South Korea.
EM limsoo@snu.ac.kr; kwangk@gilhospital.com
RI Lim, Soo/AAU-8107-2020; Oh, Tae Jung/K-8863-2018
OI Lim, Soo/0000-0002-4137-1671; Oh, Tae Jung/0000-0002-5078-6123
CR Al Rifai M, 2015, ATHEROSCLEROSIS, V239, P629, DOI 10.1016/j.atherosclerosis.2015.02.011
   Alessi MC, 2003, ARTERIOSCL THROM VAS, V23, P1262, DOI 10.1161/01.ATV.0000077401.36885.BB
   Amarapurkar A, 2007, ANN HEPATOL, V6, P37, DOI 10.1016/S1665-2681(19)31951-9
   Angulo P, 2002, NEW ENGL J MED, V346, P1221, DOI 10.1038/nrdp.2015.80
   Belfort R, 2006, NEW ENGL J MED, V355, P2297, DOI 10.1056/NEJMoa060326
   Bhat G, 2012, WORLD J HEPATOL, V4, P209, DOI 10.4254/wjh.v4.i7.209
   Bhatia LS, 2012, CURR OPIN CARDIOL, V27, P420, DOI 10.1097/HCO.0b013e328354829c
   Birkenfeld AL, 2014, HEPATOLOGY, V59, P713, DOI 10.1002/hep.26672
   Braunersreuther V, 2012, WORLD J GASTROENTERO, V18, P727, DOI 10.3748/wjg.v18.i8.727
   Byrne CD, 2014, ARTERIOSCL THROM VAS, V34, P1155, DOI 10.1161/ATVBAHA.114.303034
   Cannon CP, 2015, NEW ENGL J MED, V372, P2387, DOI 10.1056/NEJMoa1410489
   Cassader M, 2001, LIPIDS, V36, P1117, DOI 10.1007/s11745-001-0822-5
   Chen WL, 2011, EUR J PHARMACOL, V671, P107, DOI 10.1016/j.ejphar.2011.09.029
   Cho NH, 2007, DIABETES CARE, V30, P2566, DOI 10.2337/dc07-0106
   Cohen JC, 2011, SCIENCE, V332, P1519, DOI 10.1126/science.1204265
   Colhoun HM, 2004, LANCET, V364, P685, DOI 10.1016/S0140-6736(04)16895-5
   de Alwis NMW, 2008, J HEPATOL, V48, pS104, DOI 10.1016/j.jhep.2008.01.009
   DeMinicis S, 2014, HEPATOLOGY, V59, P1738, DOI 10.1002/hep.26695
   Despres J P, 2006, J Endocrinol Invest, V29, P77
   Dowman JK, 2010, QJM-INT J MED, V103, P71, DOI 10.1093/qjmed/hcp158
   Ekstedt M, 2006, HEPATOLOGY, V44, P865, DOI 10.1002/hep.21327
   Ekstedt M, 2007, J HEPATOL, V47, P135, DOI 10.1016/j.jhep.2007.02.013
   Fabbrini E, 2010, HEPATOLOGY, V51, P679, DOI 10.1002/hep.23280
   Fabbrini E, 2009, P NATL ACAD SCI USA, V106, P15430, DOI 10.1073/pnas.0904944106
   Foster T, 2011, AM J GASTROENTEROL, V106, P71, DOI 10.1038/ajg.2010.299
   Gambino R, 2011, ANTIOXID REDOX SIGN, V15, P1325, DOI 10.1089/ars.2009.3058
   Gentric G, 2015, J CLIN INVEST, V125, P981, DOI 10.1172/JCI73957
   Giby VG, 2014, WORLD J HEPATOL, V6, P570, DOI 10.4254/wjh.v6.i8.570
   Hamaguchi M, 2007, WORLD J GASTROENTERO, V13, P1579, DOI 10.3748/wjg.v13.i10.1579
   Hamirani YS, 2014, J CLIN EXP CARDIOL, V5
   Hanley AJG, 2005, DIABETES, V54, P3140, DOI 10.2337/diabetes.54.11.3140
   Hashizume H, 2013, ACTA MED OKAYAMA, V67, P45
   Haukeland JW, 2009, SCAND J GASTROENTERO, V44, P853, DOI 10.1080/00365520902845268
   Herder C, 2006, DIABETES, V55, P2340, DOI 10.2337/db05-1320
   Hotamisligil GS, 2003, INT J OBESITY, V27, pS53, DOI 10.1038/sj.ijo.0802502
   Hyogo H, 2007, J GASTROEN HEPATOL, V22, P1112, DOI 10.1111/j.1440-1746.2007.04943.x
   Hyogo H, 2011, HEPATOL RES, V41, P1057, DOI 10.1111/j.1872-034X.2011.00849.x
   Iwamoto K, 2008, J GASTROENTEROL, V43, P298, DOI 10.1007/s00535-007-2152-7
   Jialal I, 2014, J CLIN ENDOCR METAB, V99, P39, DOI 10.1210/jc.2013-3092
   Jung TW, 2013, BIOCHEM PHARMACOL, V86, P960, DOI 10.1016/j.bcp.2013.07.034
   Kellow NJ, 2014, BRIT J NUTR, V111, P1147, DOI 10.1017/S0007114513003607
   Kiechl S, 2002, NEW ENGL J MED, V347, P185, DOI 10.1056/NEJMoa012673
   Kim NH, 2014, HEART, V100, P938, DOI 10.1136/heartjnl-2013-305099
   Lavie CJ, 2009, AM J MED SCI, V338, P486, DOI 10.1097/MAJ.0b013e3181c61b66
   Leach NV, 2014, EUR J INTERN MED, V25, P762, DOI 10.1016/j.ejim.2014.09.007
   Lee JY, 2007, J HEPATOL, V47, P239, DOI 10.1016/j.jhep.2007.02.007
   Li N, 2015, NUTR METAB CARDIOVAS, V25, P218, DOI 10.1016/j.numecd.2014.10.002
   Lim S, 2008, ATHEROSCLEROSIS, V196, P398, DOI 10.1016/j.atherosclerosis.2006.11.017
   Lim S, 2011, CIRC J, V75, P1019, DOI 10.1253/circj.CJ-10-1240
   Liu KH, 2006, DIABETES CARE, V29, P379, DOI 10.2337/diacare.29.02.06.dc05-1578
   Long W, 2014, GEN COMP ENDOCR, V206, P1, DOI 10.1016/j.ygcen.2014.07.003
   Loomba R, 2013, NAT REV GASTRO HEPAT, V10, P686, DOI 10.1038/nrgastro.2013.171
   Ma YY, 2013, WORLD J GASTROENTERO, V19, P6911, DOI 10.3748/wjg.v19.i40.6911
   Marchesini G, 2001, DIABETES, V50, P1844, DOI 10.2337/diabetes.50.8.1844
   Marcos A, 2000, TRANSPLANTATION, V69, P2410, DOI 10.1097/00007890-200006150-00034
   Matteoni CA, 1999, GASTROENTEROLOGY, V116, P1413, DOI 10.1016/S0016-5085(99)70506-8
   Maximos M, 2015, HEPATOLOGY, V61, P153, DOI 10.1002/hep.27395
   Meshkani R, 2009, CLIN BIOCHEM, V42, P1331, DOI 10.1016/j.clinbiochem.2009.05.018
   Miele L, 2009, HEPATOLOGY, V49, P1877, DOI 10.1002/hep.22848
   Mouzaki M, 2013, HEPATOLOGY, V58, P120, DOI 10.1002/hep.26319
   Mummadi RR, 2008, CLIN GASTROENTEROL H, V6, P1396, DOI 10.1016/j.cgh.2008.08.012
   Musso G, 2011, CURR OPIN LIPIDOL, V22, P489, DOI 10.1097/MOL.0b013e32834c37ee
   Nakanishi N, 2004, DIABETES CARE, V27, P1427, DOI 10.2337/diacare.27.6.1427
   Pagano C, 2005, EUR J ENDOCRINOL, V152, P113, DOI 10.1530/eje.1.01821
   Perry IJ, 1998, DIABETES CARE, V21, P732, DOI 10.2337/diacare.21.5.732
   Portillo-Sanchez P, 2015, J CLIN ENDOCR METAB, V100, P2231, DOI 10.1210/jc.2015-1966
   Rafiq N, 2009, CLIN GASTROENTEROL H, V7, P234, DOI 10.1016/j.cgh.2008.11.005
   Raman M, 2013, CLIN GASTROENTEROL H, V11, P868, DOI 10.1016/j.cgh.2013.02.015
   Sabaté JM, 2008, OBES SURG, V18, P371, DOI 10.1007/s11695-007-9398-2
   Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929
   Sattar N, 2004, DIABETES, V53, P2855, DOI 10.2337/diabetes.53.11.2855
   Schnabl B, 2014, GASTROENTEROLOGY, V146, P1513, DOI 10.1053/j.gastro.2014.01.020
   Severova MM, 2012, TERAPEVT ARKH, V84, P15
   Sharifnia T., 2015, AM J PHYSL GASTROINT
   Shibata R, 2005, NAT MED, V11, P1096, DOI 10.1038/nm1295
   Shields William W, 2009, Therap Adv Gastroenterol, V2, P157, DOI 10.1177/1756283X09105462
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Song YM, 2015, AUTOPHAGY, V11, P46, DOI 10.4161/15548627.2014.984271
   Speliotes EK, 2010, HEPATOLOGY, V51, P1979, DOI 10.1002/hep.23593
   Stefan N, 2011, DIABETES, V60, P2011, DOI 10.2337/db11-0231
   Stefan N, 2008, ENDOCR REV, V29, P939, DOI 10.1210/er.2008-0009
   Stepanova M, 2012, CLIN GASTROENTEROL H, V10, P646, DOI 10.1016/j.cgh.2011.12.039
   Tahara N, 2012, DIABETES CARE, V35, P2618, DOI 10.2337/dc12-0087
   Targher G, 2007, DIABETES CARE, V30, P2119, DOI 10.2337/dc07-0349
   Targher G, 2010, NEW ENGL J MED, V363, P1341, DOI 10.1056/NEJMra0912063
   Tilg H, 2010, CURR OPIN CLIN NUTR, V13, P391, DOI 10.1097/MCO.0b013e32833a87cc
   Tilg H, 2008, TRENDS ENDOCRIN MET, V19, P371, DOI 10.1016/j.tem.2008.08.005
   Toledo FGS, 2006, DIABETES CARE, V29, P1845, DOI 10.2337/dc06-0455
   Tremaroli V, 2012, NATURE, V489, P242, DOI 10.1038/nature11552
   Tuyama AC, 2012, J DIABETES, V4, P266, DOI 10.1111/j.1753-0407.2012.00204.x
   VanWagner LB, 2015, HEPATOLOGY, V62, P773, DOI 10.1002/hep.27869
   Vozarova B, 2002, DIABETES, V51, P1889, DOI 10.2337/diabetes.51.6.1889
   Wang FS, 2014, HEPATOLOGY, V60, P2099, DOI 10.1002/hep.27406
   Wang HJ, 2013, METHOD CELL BIOL, V116, P107, DOI 10.1016/B978-0-12-408051-5.00007-3
   Wang W, 2013, PLOS ONE, V8, DOI [10.1155/2013/758750, 10.1371/journal.pone.0076538, 10.1371/journal.pone.0063591]
   Wang XC, 2015, ENDOCRINE, V48, P143, DOI 10.1007/s12020-014-0247-5
   Wigg AJ, 2001, GUT, V48, P206, DOI 10.1136/gut.48.2.206
   Williamson RM, 2011, DIABETES CARE, V34, P1139, DOI 10.2337/dc10-2229
   Wong VWS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0062885
   Yamada J, 2006, ATHEROSCLEROSIS, V189, P198, DOI 10.1016/j.atherosclerosis.2005.11.036
   Zois CD, 2010, WORLD J GASTROENTERO, V16, P3944, DOI 10.3748/wjg.v16.i31.3944
NR 101
TC 56
Z9 60
U1 0
U2 50
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD DEC 15
PY 2015
VL 201
BP 408
EP 414
DI 10.1016/j.ijcard.2015.08.107
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CY1CL
UT WOS:000366144200120
PM 26310987
DA 2025-06-11
ER

PT J
AU Nascimento-Carvalho, B
   Dos-Santos, A
   Da Costa-Santos, N
   Carvalho, SL
   de Moraes, OA
   Santos, CP
   De Angelis, K
   Caperuto, EC
   Irigoyen, MC
   Scapini, KB
   Sanches, IC
AF Nascimento-Carvalho, Bruno
   Dos-Santos, Adriano
   Da Costa-Santos, Nicolas
   Carvalho, Sabrina L.
   de Moraes, Oscar A.
   Santos, Camila P.
   De Angelis, Katia
   Caperuto, Erico C.
   Irigoyen, Maria-Claudia
   Scapini, Katia B.
   Sanches, Iris C.
TI Food readjustment plus exercise training improves cardiovascular
   autonomic control and baroreflex sensitivity in high-fat diet-fed
   ovariectomized mice
SO PHYSIOLOGICAL REPORTS
LA English
DT Article
DE autonomic nervous system; food adjustment; inflammation; menopause;
   physical training
ID OXIDATIVE STRESS; BLOOD-PRESSURE; HEART-RATE; ESTROGEN; MODEL;
   ASSOCIATION; VARIABILITY; RESISTANCE; IMPACT
AB Despite consensus on the benefits of food readjustment and/or moderate-intensity continuous exercise in the treatment of cardiometabolic risk factors, there is little evidence of the association between these two cardiovascular risk management strategies after menopause. Thus, the objective of this study was to evaluate the effects of food readjustment and/or exercise training on metabolic, hemodynamic, autonomic, and inflammatory parameters in a model of loss of ovarian function with diet-induced obesity. Forty C57BL/6J ovariectomized mice were divided into the following groups: high-fat diet-fed - 60% lipids throughout the protocol (HF), food readjustment - 60% lipids for 5 weeks, readjusted to 10% for the next 5 weeks (FR), high-fat diet-fed undergoing moderate-intensity exercise training (HFT), and food readjustment associated with moderate-intensity exercise training (FRT). Blood glucose evaluations and oral glucose tolerance tests were performed. Blood pressure was assessed by direct intra-arterial measurement. Baroreflex sensitivity was tested using heart rate phenylephrine and sodium nitroprusside induced blood pressure changes. Cardiovascular autonomic modulation was evaluated in time and frequency domains. Inflammatory profile was evaluated by IL-6, IL-10 cytokines, and TNF-alpha measurements. Only the exercise training associated with food readjustment strategy induced improved functional capacity, body composition, metabolic parameters, inflammatory profile, and resting bradycardia, while positively changing cardiovascular autonomic modulation and increasing baroreflex sensitivity. Our findings demonstrate that the association of these strategies seems to be effective in the management of cardiometabolic risk in a model of loss of ovarian function with diet-induced obesity.
C1 [Nascimento-Carvalho, Bruno; de Moraes, Oscar A.; Irigoyen, Maria-Claudia] Univ Sao Paulo InCor HCFMUSP, Hosp Clin, Fac Med, Unidade Hipertensao, Sao Paulo, Brazil.
   [Nascimento-Carvalho, Bruno; Dos-Santos, Adriano; Da Costa-Santos, Nicolas; Carvalho, Sabrina L.; Caperuto, Erico C.; Scapini, Katia B.] Sao Judas Tadeu Univ USJT, Human Movement Lab, Sao Paulo, Brazil.
   [Santos, Camila P.; De Angelis, Katia] Fed Univ Sao Paulo Unifesp, Dept Med, Sao Paulo, Brazil.
   [Irigoyen, Maria-Claudia] Univ Sao Paulo InCor HCFMUSP, Hosp Clin, Fac Med, Unidade Hipertensao,Inst Coracao, Ave Dr Eneas Carvalho de Aguiar 44, BR-05403900 Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade Sao Judas Tadeu; Universidade
   Federal de Sao Paulo (UNIFESP)
RP Irigoyen, MC (corresponding author), Univ Sao Paulo InCor HCFMUSP, Hosp Clin, Fac Med, Unidade Hipertensao,Inst Coracao, Ave Dr Eneas Carvalho de Aguiar 44, BR-05403900 Sao Paulo, SP, Brazil.
EM hipirigoyen@gmail.com
RI IRIGOYEN, MARIA/N-6880-2014; Nascimento-Carvalho, Bruno/HLX-3548-2023;
   Caperuto, Erico/I-3605-2014; DE ANGELIS, KATIA/I-6098-2016; Santos,
   Adriano/ABH-6885-2020; Sanches, Iris Callado/D-5079-2013
OI Sanches, Iris Callado/0000-0001-6195-4340; do Nascimento Carvalho,
   Bruno/0000-0002-0283-7432
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior- Brazil
   (CAPES) [001?]; Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (PQ -CNPq) [307138/2015-1, 435123/2018-1]; ANIMA
   INSTITUTE-AI
FX This study was financed in part by the Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior- Brazil (CAPES)- Finance Code 001?; Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (PQ -CNPq -process
   307138/2015-1 and process 435123/2018-1); and ANIMA INSTITUTE-AI. CAPES
   provided support for personal demands of the main author; CNPq provided
   support for laboratory demands of research. ANIMA provided support for
   Human Movement Lab, Sao Judas University.
CR Adachi T, 2011, HYPERTENSION, V57, P723, DOI 10.1161/HYPERTENSIONAHA.110.163147
   Ambikairajah A, 2019, AM J OBSTET GYNECOL, V221, P393, DOI 10.1016/j.ajog.2019.04.023
   [Anonymous], 2003, Rev Bras Med Esporte
   Bernardes N, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-26816-4
   Braga VAVN, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0125388
   Conti FF, 2015, AM J PHYSIOL-REG I, V309, pR1532, DOI 10.1152/ajpregu.00076.2015
   Costa J, 2019, CLIN NUTR, V38, P110, DOI 10.1016/j.clnu.2018.01.006
   da Palma RK, 2016, J APPL PHYSIOL, V121, P1032, DOI 10.1152/japplphysiol.00130.2016
   De Angelis K, 2004, J APPL PHYSIOL, V96, P2174, DOI 10.1152/japplphysiol.00870.2003
   Ernst G, 2017, FRONT PUBLIC HEALTH, V5, DOI 10.3389/fpubh.2017.00240
   Feriani DJ, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00053
   Flues K, 2010, MATURITAS, V65, P267, DOI 10.1016/j.maturitas.2009.11.007
   Goncalves GK, 2017, MED SCI MONIT BASIC, V23, P380, DOI 10.12659/MSMBR.907162
   Guarino D, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00665
   Haas E, 2009, CIRC RES, V104, P288, DOI 10.1161/CIRCRESAHA.108.190892
   Heeren MV, 2009, MATURITAS, V62, P200, DOI 10.1016/j.maturitas.2008.12.011
   Irigoyen MC, 2005, HYPERTENSION, V46, P998, DOI 10.1161/01.HYP.0000176238.90688.6b
   Ludgero-Correia A, 2012, NUTRITION, V28, P316, DOI 10.1016/j.nut.2011.07.014
   Marchon C, 2015, CELL PHYSIOL BIOCHEM, V35, P397, DOI 10.1159/000369705
   Moraes-Silva IC, 2010, CLIN EXP PHARMACOL P, V37, pe114, DOI 10.1111/j.1440-1681.2009.05333.x
   Pae M, 2018, J NUTR BIOCHEM, V57, P93, DOI 10.1016/j.jnutbio.2018.03.011
   Pelat M, 2003, CIRCULATION, V107, P2480, DOI 10.1161/01.CIR.0000065601.83526.3E
   Peppa M., 2012, ENDOCRINOLOGY METABO, V2, P2161, DOI [10.4172/2161-1017.S1-009, DOI 10.4172/2161-1017.S1-009]
   Poirier P, 2003, OBES RES, V11, P1040, DOI 10.1038/oby.2003.143
   REEVES PG, 1993, J NUTR, V123, P1939, DOI 10.1093/jn/123.11.1939
   Roberts CK, 2001, J APPL PHYSIOL, V91, P2005, DOI 10.1152/jappl.2001.91.5.2005
   Sanches IC, 2015, J APPL PHYSIOL, V119, P656, DOI 10.1152/japplphysiol.00883.2014
   Shi HF, 2013, PROG MOL BIOL TRANSL, V114, P193, DOI 10.1016/B978-0-12-386933-3.00006-6
   Shimojo GL, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01471
   Son Won-Mok, 2017, Osong Public Health Res Perspect, V8, P369, DOI 10.24171/j.phrp.2017.8.6.02
   Song JX, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00602
   Thireau J, 2008, EXP PHYSIOL, V93, P83, DOI 10.1113/expphysiol.2007.040733
   Toth M. E., 2022, DIFFERENCES, V13, P1, DOI [10.1186/s13293-022-00414-6, DOI 10.1186/S13293-022-00414-6]
   Whelton PK, 2018, J AM COLL CARDIOL, V71, pE127, DOI 10.1016/j.jacc.2017.11.006
   Ziegler D, 2015, DIABETES CARE, V38, P1750, DOI 10.2337/dc15-0466
NR 35
TC 2
Z9 2
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2051-817X
J9 PHYSIOL REP
JI PHYSIOL. REP.
PD MAR
PY 2023
VL 11
IS 5
AR e15609
DI 10.14814/phy2.15609
PG 10
WC Physiology
WE Emerging Sources Citation Index (ESCI)
SC Physiology
GA 9S8LO
UT WOS:000946588200001
PM 36898722
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gong, ZT
   Zhang, LS
   Shi, YL
AF Gong, Zhentao
   Zhang, Lingshan
   Shi, Yingli
TI The potential role of uric acid in women with polycystic ovary syndrome
SO GYNECOLOGICAL ENDOCRINOLOGY
LA English
DT Review
DE Polycystic ovary syndrome; uric acid; hyperandrogenism; metabolic
   syndrome; oxidative stress; insulin resistance
ID HORMONE REPLACEMENT THERAPY; INSULIN-RESISTANCE; RISK-FACTORS; METABOLIC
   SYNDROME; OXIDATIVE STRESS; SERUM URATE; BARIATRIC SURGERY;
   BLOOD-PRESSURE; WEIGHT-LOSS; ANTIOXIDANT DEFENSE
AB Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder among women of reproductive age and is associated with a variety of multi-system complications. The prevailing treatment strategy for PCOS is to individualize the interventions based on individual symptoms and patient complaints. However, optimal efficacy in treatment necessitates a focus on addressing the underlying pathogenic mechanisms. Uric acid (UA), the end product of purine metabolism, has been suggested to be involved in the development of several diseases, including PCOS. However, the precise mechanisms by which UA may affect PCOS remain incompletely understood. This literature review aims to investigate the correlation between UA and the various clinical presentations of PCOS, such as hyperandrogenism, insulin resistance (IR), ovulation disorders, obesity, and other related manifestations, through the analysis of epidemiological and clinical studies. The purpose of this study is to improve our comprehension of how UA contributes to each aspect of PCOS and their interrelationship, thus identifying the potential role of UA as a facilitator of PCOS. Furthermore, we explore potential pathways linking UA and PCOS, and propose therapeutic interventions based on these findings to optimize the management of this condition.
C1 [Gong, Zhentao; Zhang, Lingshan; Shi, Yingli] Fudan Univ, Obstet & Gynecol Hosp, Shanghai, Peoples R China.
   [Gong, Zhentao; Shi, Yingli] Fudan Univ, Shanghai Med Coll, Shanghai, Peoples R China.
   [Shi, Yingli] Shanghai Key Lab Female Reprod Endocrine Related D, Shanghai, Peoples R China.
   [Shi, Yingli] 128 Shenyang Rd, Shanghai, Peoples R China.
C3 Fudan University; Fudan University
RP Shi, YL (corresponding author), 128 Shenyang Rd, Shanghai, Peoples R China.
EM shiyingli@fudan.edu.cn
RI Gong, Zhentao/KDO-2143-2024
OI Gong, Zhentao/0000-0002-1664-3612; Shi, Yingli/0000-0002-7595-6678
FU Natural Science Foundation of Shanghai [19ZR1406700]
FX This research was sponsored by Natural Science Foundation of Shanghai
   [No. 19ZR1406700 to Yingli Shi].
CR ADAMOPOULOS D, 1977, ACTA ENDOCRINOL-COP, V85, P198
   Agarwal A, 2012, REPROD BIOL ENDOCRIN, V10, DOI 10.1186/1477-7827-10-49
   Akasaka H, 2014, NEPHROL DIAL TRANSPL, V29, P1932, DOI 10.1093/ndt/gfu197
   ALEXIOU M, 1992, DEVELOPMENT, V114, P185
   Ali N, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0206850
   AMES BN, 1981, P NATL ACAD SCI-BIOL, V78, P6858, DOI 10.1073/pnas.78.11.6858
   Apel K, 2004, ANNU REV PLANT BIOL, V55, P373, DOI 10.1146/annurev.arplant.55.031903.141701
   Athyros VG, 2004, AM J KIDNEY DIS, V43, P589, DOI 10.1053/j.ajkd.2003.12.023
   Bagnati M, 1999, BIOCHEM J, V340, P143, DOI 10.1042/0264-6021:3400143
   Bakker SJL, 2001, ATHEROSCLEROSIS, V155, P283, DOI 10.1016/S0021-9150(00)00745-0
   Balakrishnan VS, 1996, AM J PHYSIOL-RENAL, V271, pF374, DOI 10.1152/ajprenal.1996.271.2.F374
   BALAKRISHNAN VS, 1993, AM J PHYSIOL, V265, pF504, DOI 10.1152/ajprenal.1993.265.4.F504
   Baldwin W, 2011, DIABETES, V60, P1258, DOI 10.2337/db10-0916
   Barbieri L, 2015, ATHEROSCLEROSIS, V241, P241, DOI 10.1016/j.atherosclerosis.2015.03.030
   Barroso E, 2011, ENDOCRINOLOGY, V152, P1848, DOI 10.1210/en.2010-1468
   Berg AH, 2004, AM J PHYSIOL-ENDOC M, V287, pE1178, DOI 10.1152/ajpendo.00002.2004
   Boomsma CM, 2006, HUM REPROD UPDATE, V12, P673, DOI 10.1093/humupd/dml036
   Borghi C, 2015, J HYPERTENS, V33, P1729, DOI 10.1097/HJH.0000000000000701
   Buchwald H, 2009, AM J MED, V122, P248, DOI 10.1016/j.amjmed.2008.09.041
   BURGHEN GA, 1980, J CLIN ENDOCR METAB, V50, P113, DOI 10.1210/jcem-50-1-113
   CARTER J, 1989, AUST NZ J OBSTET GYN, V29, P313, DOI 10.1111/j.1479-828X.1989.tb01751.x
   Cassano E, 1999, CELL PHYSIOL BIOCHEM, V9, P106, DOI 10.1159/000016307
   Cassano V, 2020, NUTRIENTS, V12, DOI 10.3390/nu12092509
   Choi HK, 2005, ARCH INTERN MED, V165, P742, DOI 10.1001/archinte.165.7.742
   Choi HK, 2004, NEW ENGL J MED, V350, P1093, DOI 10.1056/NEJMoa035700
   Choi HK, 2007, AM J MED, V120, P442, DOI 10.1016/j.amjmed.2006.06.040
   Choi HK, 2020, ARTHRITIS RHEUMATOL, V72, P157, DOI 10.1002/art.41067
   Chou P, 2001, J RHEUMATOL, V28, P571
   Chu NF, 2000, EUR J EPIDEMIOL, V16, P13, DOI 10.1023/A:1007654507054
   Cicerchi C, 2014, FASEB J, V28, P3339, DOI 10.1096/fj.13-243634
   COOK DG, 1986, POSTGRAD MED J, V62, P1001, DOI 10.1136/pgmj.62.733.1001
   Dalbeth N, 2014, ANN RHEUM DIS, V73, P797, DOI 10.1136/annrheumdis-2013-203970
   DARLINGTON LG, 1991, ADV EXP MED BIOL, V309, P235
   Dessein PH, 2000, ANN RHEUM DIS, V59, P539, DOI 10.1136/ard.59.7.539
   Durmus U, 2017, J ENDOCRINOL INVEST, V40, P487, DOI 10.1007/s40618-016-0582-x
   Ee PLR, 2004, CANCER RES, V64, P1247, DOI 10.1158/0008-5472.CAN-03-3583
   El Ridi R, 2017, J ADV RES, V8, P487, DOI 10.1016/j.jare.2017.03.003
   El-Eshmawy MM, 2022, BMC ENDOCR DISORD, V22, DOI 10.1186/s12902-022-01240-y
   Enomoto A, 2002, NATURE, V417, P447, DOI 10.1038/nature742
   FACCHINI F, 1991, JAMA-J AM MED ASSOC, V266, P3008, DOI 10.1001/jama.266.21.3008
   FRANSEN R, 1995, J AM SOC NEPHROL, V6, P1491
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gherghina ME, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23063188
   Goodarzi MO, 2003, FERTIL STERIL, V80, P255, DOI 10.1016/S0015-0282(03)00734-9
   GRESSER U, 1994, ADV EXP MED BIOL, V370, P87
   Griendling KK, 2021, CIRC RES, V128, P993, DOI 10.1161/CIRCRESAHA.121.318063
   Hak AE, 2010, ANN RHEUM DIS, V69, P1305, DOI 10.1136/ard.2009.109884
   HALLIWELL B, 1994, NUTR REV, V52, P253
   Hamburger Max, 2011, Postgrad Med, V123, P3, DOI 10.3810/pgm.2011.11.2511
   Hardie DG, 1997, BIOCHEM SOC T, V25, P1229, DOI 10.1042/bst0251229
   HERMAN JB, 1982, LANCET, V2, P240
   Hoque KM, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-16525-w
   Hosoyamada M, 2010, NUCLEOS NUCLEOT NUCL, V29, P574, DOI 10.1080/15257770.2010.494651
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Imai Y, 2005, CANCER RES, V65, P596
   Ioannou GN, 2013, ATHEROSCLEROSIS, V226, P220, DOI 10.1016/j.atherosclerosis.2012.10.044
   Jakse B, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081736
   Johnson RJ, 2013, DIABETES, V62, P3307, DOI 10.2337/db12-1814
   Johnson RJ, 2011, SEMIN NEPHROL, V31, P394, DOI 10.1016/j.semnephrol.2011.08.002
   Jung JH, 2018, MENOPAUSE, V25, P77, DOI 10.1097/GME.0000000000000953
   Kawano Y, 2000, J HYPERTENS, V18, P1451, DOI 10.1097/00004872-200018100-00013
   Khitan Z, 2013, J NUTR METAB, V2013, DOI 10.1155/2013/682673
   KONO S, 1994, INT J EPIDEMIOL, V23, P517, DOI 10.1093/ije/23.3.517
   Koratala A, 2016, NEPHRON, V134, P231, DOI 10.1159/000448629
   Kuwabara M, 2018, NUTRIENTS, V10, DOI 10.3390/nu10081011
   Kuwabara M, 2018, INT J CARDIOL, V261, P183, DOI 10.1016/j.ijcard.2018.03.045
   Kuwabara M, 2017, HYPERTENSION, V69, P1036, DOI [10.1161/HYPERTENSIONAHA.116.08998, 10.1161/hypertensionaha.116.08998]
   Kuwabara M, 2017, AM J NEPHROL, V45, P330, DOI 10.1159/000464260
   Lanaspa MA, 2012, J BIOL CHEM, V287, P40732, DOI 10.1074/jbc.M112.399899
   Laughon SK, 2009, AM J OBSTET GYNECOL, V201, DOI 10.1016/j.ajog.2009.06.065
   LAVY G, 1990, HUM REPROD, V5, P529, DOI 10.1093/oxfordjournals.humrep.a137136
   Legro RS, 2001, AM J MED, V111, P607, DOI 10.1016/S0002-9343(01)00948-2
   Lima WG, 2015, BIOCHIMIE, V116, P17, DOI 10.1016/j.biochi.2015.06.025
   Liu R, 2015, BIOMED RES INT-UK, V2015, DOI 10.1155/2015/762820
   Lu JE, 2021, RHEUMATOLOGY, V60, P3628, DOI 10.1093/rheumatology/keaa822
   Luque-Ramírez M, 2008, HUM REPROD, V23, P1594, DOI 10.1093/humrep/den095
   Macut D, 2011, EXP CLIN ENDOCR DIAB, V119, P451, DOI 10.1055/s-0031-1279740
   Maglio C, 2017, ANN RHEUM DIS, V76, DOI 10.1136/annrheumdis-2016-209958
   Maiuolo J, 2016, INT J CARDIOL, V213, P8, DOI 10.1016/j.ijcard.2015.08.109
   Major TJ, 2018, BMJ-BRIT MED J, V363, DOI 10.1136/bmj.k3951
   Mandal AK, 2015, ANNU REV PHYSIOL, V77, P323, DOI 10.1146/annurev-physiol-021113-170343
   Martinez-Hervas S, 2010, NUTR METAB CARDIOVAS, V20, P734, DOI 10.1016/j.numecd.2009.06.003
   Masuo K, 2003, HYPERTENSION, V42, P474, DOI 10.1161/01.HYP.0000091371.53502.D3
   Mazidi M, 2018, ATHEROSCLEROSIS, V270, P180, DOI 10.1016/j.atherosclerosis.2017.12.033
   Mehta T, 2015, AM J HYPERTENS, V28, P877, DOI 10.1093/ajh/hpu253
   MESSERLI FH, 1980, ANN INTERN MED, V93, P817, DOI 10.7326/0003-4819-93-6-817
   Milionis HJ, 2004, AM HEART J, V148, P635, DOI 10.1016/j.ahj.2004.04.005
   MODAN M, 1987, DIABETOLOGIA, V30, P713, DOI 10.1007/BF00296994
   Montagne CT, 2000, DIABETES, V49, P883, DOI 10.2337/diabetes.49.6.883
   Moran LJ, 2010, HUM REPROD UPDATE, V16, P347, DOI 10.1093/humupd/dmq001
   Mu LS, 2018, REPROD BIOL ENDOCRIN, V16, DOI 10.1186/s12958-018-0419-x
   Mumford SL, 2013, HUM REPROD, V28, P1853, DOI 10.1093/humrep/det085
   Muscelli E, 1996, AM J HYPERTENS, V9, P746, DOI 10.1016/0895-7061(96)00098-2
   Nakagawa T, 2006, AM J PHYSIOL-RENAL, V290, pF625, DOI 10.1152/ajprenal.00140.2005
   Nakanishi N, 1999, INT J EPIDEMIOL, V28, P888, DOI 10.1093/ije/28.5.888
   Neogi T, 2014, AM J MED, V127, P311, DOI 10.1016/j.amjmed.2013.12.019
   Nikkila E A, 1969, Adv Lipid Res, V7, P63
   Nishino T, 2015, J BIOL INORG CHEM, V20, P195, DOI 10.1007/s00775-014-1210-x
   Novak S, 2007, CURR MED RES OPIN, V23, P623, DOI 10.1185/030079906X167651
   Oberbach A, 2014, SURG OBES RELAT DIS, V10, P684, DOI 10.1016/j.soard.2013.12.010
   Oda M, 2002, MOL BIOL EVOL, V19, P640, DOI 10.1093/oxfordjournals.molbev.a004123
   Ogura T, 2004, METABOLISM, V53, P448, DOI 10.1016/j.metabol.2003.11.017
   OKADA M, 1982, J CHRON DIS, V35, P173, DOI 10.1016/0021-9681(82)90137-0
   Osibogun O, 2020, TRENDS CARDIOVAS MED, V30, P399, DOI 10.1016/j.tcm.2019.08.010
   Palomba S, 2015, HUM REPROD UPDATE, V21, P575, DOI 10.1093/humupd/dmv029
   PIZZICHINI M, 1990, HORM METAB RES, V22, P334, DOI 10.1055/s-2007-1004914
   Prasad S, 2017, CANCER LETT, V387, P95, DOI 10.1016/j.canlet.2016.03.042
   Puig J G, 1986, Adv Exp Med Biol, V195 Pt A, P317
   Qaseem A, 2017, ANN INTERN MED, V166, P58, DOI 10.7326/M16-0570
   Rathmann W, 1998, ANN EPIDEMIOL, V8, P250, DOI 10.1016/S1047-2797(97)00204-4
   Rathmann W, 2007, EUR J EPIDEMIOL, V22, P439, DOI 10.1007/s10654-007-9132-3
   Richette P, 2017, ANN RHEUM DIS, V76, P29, DOI [10.1136/annrheumdis-2016-209707, 10.1136/annrheumdis-2016-210356]
   Roumeliotis S, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081911
   Ruebel ML, 2019, AM J PHYSIOL-ENDOC M, V316, pE383, DOI 10.1152/ajpendo.00401.2018
   Sautin YY, 2008, NUCLEOS NUCLEOT NUCL, V27, P608, DOI 10.1080/15257770802138558
   Sautin YY, 2007, AM J PHYSIOL-CELL PH, V293, pC584, DOI 10.1152/ajpcell.00600.2006
   Sidoti A, 2017, NEPHROLOGY, V22, P279, DOI 10.1111/nep.12763
   Song PG, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-22570-9
   SORENSEN LEIF B., 1965, ARTHRITIS RHEUM, V8, P694, DOI 10.1002/art.1780080429
   Stener-Victorin E, 2020, ENDOCR REV, V41, DOI 10.1210/endrev/bnaa010
   Stephen F., 1995, N. Engl. J. Med, V333, P1
   Sumino H, 1999, LANCET, V354, P650, DOI 10.1016/S0140-6736(99)92381-8
   terMaaten JC, 1997, CLIN SCI, V92, P51
   Trifiò G, 2013, ANN RHEUM DIS, V72, P694, DOI 10.1136/annrheumdis-2011-201254
   Tsushima Y, 2013, J BIOL CHEM, V288, P27138, DOI 10.1074/jbc.M113.485094
   TUOMILEHTO J, 1988, AM J EPIDEMIOL, V127, P321, DOI 10.1093/oxfordjournals.aje.a114807
   VANDENBERGHE G, 1977, BIOCHEM J, V162, P601, DOI 10.1042/bj1620601
   Wang WQ, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2014-006843
   Weissgerber TL, 2015, MAYO CLIN PROC, V90, P1207, DOI 10.1016/j.mayocp.2015.05.020
   Wen XS, 2010, METABOLISM, V59, P1145, DOI 10.1016/j.metabol.2009.09.037
   Wingrove CS, 1998, METABOLISM, V47, P435, DOI 10.1016/S0026-0495(98)90056-7
   Woodward OM, 2009, P NATL ACAD SCI USA, V106, P10338, DOI 10.1073/pnas.0901249106
   Xu LQ, 2017, ONCOTARGET, V8, P100852, DOI 10.18632/oncotarget.20135
   Yahyaoui R., 2008, J Clin Endocrinol Metab
   Yamanaka H, 2011, NUCLEOS NUCLEOT NUCL, V30, P1018, DOI 10.1080/15257770.2011.596496
   YAMASHITA S, 1986, INT J OBESITY, V10, P255
   Yip K, 2020, CURR OPIN RHEUMATOL, V32, P71, DOI 10.1097/BOR.0000000000000679
   Yokose C, 2020, DIABETES CARE, V43, P2812, DOI 10.2337/dc20-1002
   Zeng CM, 2022, ENVIRON RES, V214, DOI 10.1016/j.envres.2022.113865
   Zhang YQ, 2022, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.782808
   Zhu CL, 2017, INT J ENDOCRINOL, V2017, DOI 10.1155/2017/5438157
   Zhu YY, 2010, RHEUMATOLOGY, V49, P2391, DOI 10.1093/rheumatology/keq256
NR 142
TC 1
Z9 1
U1 5
U2 14
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0951-3590
EI 1473-0766
J9 GYNECOL ENDOCRINOL
JI Gynecol. Endocrinol.
PD DEC 31
PY 2024
VL 40
IS 1
AR 2323725
DI 10.1080/09513590.2024.2323725
PG 10
WC Endocrinology & Metabolism; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Obstetrics & Gynecology
GA KD7W8
UT WOS:001178096700001
PM 39718393
OA gold
DA 2025-06-11
ER

PT J
AU Hata, J
   Harigane, Y
   Matsuoka, K
   Akaihata, H
   Yaginuma, K
   Meguro, S
   Hoshi, S
   Sato, Y
   Ogawa, S
   Uemura, M
   Kojima, Y
AF Hata, Junya
   Harigane, Yuki
   Matsuoka, Kanako
   Akaihata, Hidenori
   Yaginuma, Kei
   Meguro, Satoru
   Hoshi, Seiji
   Sato, Yuichi
   Ogawa, Soichiro
   Uemura, Motohide
   Kojima, Yoshiyuki
TI Mechanism of Androgen-Independent Stromal Proliferation in Benign
   Prostatic Hyperplasia
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE benign prostatic hyperplasia; stromal proliferation; androgen
   independent; autoimmune reaction
ID OXIDATIVE STRESS; REACTIVE STROMA; GROWTH-FACTOR; EPITHELIAL
   INTERACTIONS; TRICHOMONAS-VAGINALIS; METABOLIC SYNDROME; STEM-CELLS;
   T-CELLS; INFLAMMATION; PROGRESSION
AB Benign prostatic hyperplasia (BPH) is a chronic proliferative disease showing stromal-dominant proliferation. However, the detailed proliferation mechanism has remained unclear. Although aging and androgen have been reported as definitive risk factors for BPH, recent studies have focused on the involvement of androgen-independent factors. Androgen-independent factors include ischemia, oxidative stress, metabolic syndrome, infection, autoimmune reactions, and inflammation, with inflammation in BPH tissues playing a central role in the BPH proliferative process. Inflammation in BPH tissues by various factors finally leads to tissue remodeling and stromal proliferation through the wound healing process of the prostate. To elucidate the proliferative mechanism of BPH, a study using whole-genome gene expression analysis in a stromal-dominant BPH rat model was performed and showed that immune response-related pathways and complement classical pathways are activated. Furthermore, expression analysis using this BPH rat model showed that the autoimmune reaction triggered complement pathway activation in the proliferative process of BPH. BPH is a multifactorial disease, and understanding the role of androgen-independent factors including immune responses contributes to elucidating the pathogenesis of BPH. Androgen-independent factors may lead to new therapeutic targets for BPH, and further development of this research is expected.
C1 [Hata, Junya; Harigane, Yuki; Matsuoka, Kanako; Akaihata, Hidenori; Yaginuma, Kei; Meguro, Satoru; Hoshi, Seiji; Sato, Yuichi; Ogawa, Soichiro; Uemura, Motohide; Kojima, Yoshiyuki] Fukushima Med Univ, Dept Urol, Sch Med, 1 Hikarigaoka, Fukushima 9601295, Japan.
C3 Fukushima Medical University
RP Hata, J (corresponding author), Fukushima Med Univ, Dept Urol, Sch Med, 1 Hikarigaoka, Fukushima 9601295, Japan.
EM akju826@fmu.ac.jp; uroharry@fmu.ac.jp; kanaco@fmu.ac.jp;
   hakai@fmu.ac.jp; uro-yagi@fmu.ac.jp; s-meguro@fmu.ac.jp;
   uro-hoshi@fmu.ac.jp; ysato@fmu.ac.jp; soh@fmu.ac.jp; muemura@fmu.ac.jp;
   ykojima@fmu.ac.jp
RI hoshi, seiji/L-7385-2017
OI Matsuoka, Kanako/0000-0002-0731-4577; Yaginuma, Kei/0009-0004-1616-3266;
   Harigane, Yuki/0009-0001-8696-9853; Meguro, Satoru/0000-0003-2179-5028;
   Hata, Junya/0000-0002-7912-5468
CR ABLIN RJ, 1971, J IMMUNOL, V107, P603
   Ahmad M, 2012, INDIAN J CLIN BIOCHE, V27, P385, DOI 10.1007/s12291-012-0229-4
   Aryal M, 2007, Nepal Med Coll J, V9, P222
   Balistreri CR, 2016, AGEING RES REV, V29, P50, DOI 10.1016/j.arr.2016.06.004
   BERRY SJ, 1984, J UROLOGY, V132, P474, DOI 10.1016/S0022-5347(17)49698-4
   Bhowmick NA, 2004, SCIENCE, V303, P848, DOI 10.1126/science.1090922
   Cai Q, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9051261
   Cannarella R, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.554078
   Chen IH, 2012, NEUROUROL URODYNAM, V31, P600, DOI 10.1002/nau.21192
   Chughtai Bilal, 2011, Rev Urol, V13, P147
   CLAUS S, 1993, UROL RES, V21, P305, DOI 10.1007/BF00296825
   Cunha G R, 1992, Epithelial Cell Biol, V1, P76
   CUNHA GR, 1978, J EXP ZOOL, V205, P181, DOI 10.1002/jez.1402050203
   Cunha GR, 1996, ACTA ANAT, V155, P63
   Cunha GR, 2004, ARCH HISTOL CYTOL, V67, P417, DOI 10.1679/aohc.67.417
   CUNHA GR, 1972, ANAT REC, V172, P179, DOI 10.1002/ar.1091720206
   De Nunzio C, 2016, NAT REV UROL, V13, P613, DOI 10.1038/nrurol.2016.168
   De Nunzio C, 2012, EUR UROL, V61, P560, DOI 10.1016/j.eururo.2011.11.013
   De Nunzio C, 2011, EUR UROL, V60, P106, DOI 10.1016/j.eururo.2011.03.055
   Djavan B, 2011, CURR OPIN UROL, V21, P5, DOI 10.1097/MOU.0b013e32834100ef
   Donnell RF, 2011, CURR OPIN UROL, V21, P22, DOI 10.1097/MOU.0b013e32834100dd
   Draznin B, 2010, DIABETOLOGIA, V53, P229, DOI 10.1007/s00125-009-1558-6
   Du YF, 2015, ONCOL REP, V34, P2273, DOI 10.3892/or.2015.4201
   Edeling M, 2016, NAT REV NEPHROL, V12, P426, DOI 10.1038/nrneph.2016.54
   Emberton M, 2008, BJU INT, V102, P981, DOI 10.1111/j.1464-410X.2008.07717.x
   Estemalik J, 2017, J PERIODONTOL, V88, P823, DOI 10.1902/jop.2017.160477
   Fang C, 2021, MED RES REV, V41, P1812, DOI 10.1002/med.21778
   Fazio C, 2016, CELL DEATH DIS, V7, DOI 10.1038/cddis.2016.408
   Franco OE, 2011, CANCER RES, V71, P1272, DOI 10.1158/0008-5472.CAN-10-3142
   FRANKS LM, 1954, ANN ROY COLL SURG, V14, P92
   Fujii S, 2019, PROSTATE, V79, DOI 10.1002/pros.23759
   Gonnissen A, 2013, INT J MOL SCI, V14, P13979, DOI 10.3390/ijms140713979
   Haga N, 2019, PROSTATE, V79, P574, DOI 10.1002/pros.23763
   Hahn AM, 2014, J PHARMACOL EXP THER, V351, P605, DOI 10.1124/jpet.114.218693
   Hata J, 2020, INT J UROL, V27, P676, DOI 10.1111/iju.14265
   Hata J, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-57001-w
   Hata J, 2016, INT J UROL, V23, P599, DOI 10.1111/iju.13106
   Hayward SW, 1998, DIFFERENTIATION, V63, P131, DOI 10.1046/j.1432-0436.1998.6330131.x
   Hayward SW, 1996, ACTA ANAT, V155, P94
   Honda-Takinami R, 2022, FUKUSHIMA J MED SCI, V68, P161, DOI 10.5387/fms.2022-34
   Isaacs JT, 2008, PROSTATE, V68, P1025, DOI 10.1002/pros.20763
   ISAACS JT, 1993, EUR UROL, V25, P6
   Kamijo T, 2001, PROSTATE, V49, P122, DOI 10.1002/pros.1126
   Kim JH, 2018, PARASITE IMMUNOL, V40, DOI 10.1111/pim.12531
   Kim JH, 2016, PROSTATE, V76, P1431, DOI 10.1002/pros.23227
   Klyushnenkova EN, 2005, CLIN CANCER RES, V11, P2853, DOI 10.1158/1078-0432.CCR-04-1927
   Klyushnenkova EN, 2004, J IMMUNOTHER, V27, P136, DOI 10.1097/00002371-200403000-00007
   KOHNEN PW, 1979, J UROLOGY, V121, P755, DOI 10.1016/S0022-5347(17)56980-3
   Kramer G, 2006, CURR OPIN UROL, V16, P25
   Kramer G, 2007, EUR UROL, V51, P1202, DOI 10.1016/j.eururo.2006.12.011
   Kullisaar T, 2012, PROSTATE, V72, P977, DOI 10.1002/pros.21502
   Lee KL, 2004, J UROLOGY, V172, P1784, DOI 10.1097/01.ju.0000133655.71782.14
   Liedtke V, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24076166
   Liguori I, 2018, CLIN INTERV AGING, V13, P757, DOI 10.2147/CIA.S158513
   Liu DQ, 2021, PROSTATE, V81, P1435, DOI 10.1002/pros.24241
   Ma B, 2016, FRONT IMMUNOL, V7, DOI 10.3389/fimmu.2016.00378
   Macoska JA, 2011, DIFFERENTIATION, V82, P253, DOI 10.1016/j.diff.2011.04.003
   Madersbacher S, 2019, GERONTOLOGY, V65, P458, DOI 10.1159/000496289
   Magri V, 2018, ARCH ITAL UROL ANDRO, V90, P227, DOI 10.4081/aiua.2018.4.227
   McConnell JD, 2003, NEW ENGL J MED, V349, P2387, DOI 10.1056/NEJMoa030656
   MCKEEHAN WL, 1984, CANCER RES, V44, P1998
   McLaren ID, 2011, DIFFERENTIATION, V82, P237, DOI 10.1016/j.diff.2011.06.001
   MCNEAL J, 1990, UROL CLIN N AM, V17, P477
   McNeal J E, 1984, Prog Clin Biol Res, V145, P27
   MCNEAL JE, 1972, J UROLOGY, V107, P1008, DOI 10.1016/S0022-5347(17)61195-9
   MCNEAL JE, 1981, PROSTATE, V2, P35, DOI 10.1002/pros.2990020105
   MCNEAL JE, 1978, INVEST UROL, V15, P340
   MCNEAL JE, 1968, AM J CLIN PATHOL, V49, P347
   Memarzadeh S, 2007, CANCER CELL, V12, P572, DOI 10.1016/j.ccr.2007.11.002
   Minciullo PL, 2015, UROL INT, V94, P249, DOI 10.1159/000366210
   Morelli A, 2011, J SEX MED, V8, P2746, DOI 10.1111/j.1743-6109.2011.02416.x
   Mori F, 2009, J UROLOGY, V181, P890, DOI 10.1016/j.juro.2008.10.067
   Morrison C, 2000, UROL RES, V28, P304, DOI 10.1007/s002400000123
   Murphy AB, 2009, DRUGS, V69, P71, DOI 10.2165/00003495-200969010-00005
   Nicholson TM, 2011, DIFFERENTIATION, V82, P184, DOI 10.1016/j.diff.2011.04.006
   Nickel JC, 2008, EUR UROL, V54, P1379, DOI 10.1016/j.eururo.2007.11.026
   Nickel JC, 2008, UROL CLIN N AM, V35, P109, DOI 10.1016/j.ucl.2007.09.012
   Okada K, 2022, FRONT CELL INFECT MI, V12, DOI 10.3389/fcimb.2022.1048319
   Palapattu GS, 2005, CARCINOGENESIS, V26, P1170, DOI 10.1093/carcin/bgh317
   Parsons JK, 2006, J CLIN ENDOCR METAB, V91, P2562, DOI 10.1210/jc.2005-2799
   Peng YC, 2015, DEV BIOL, V400, P94, DOI 10.1016/j.ydbio.2015.01.019
   Penna G, 2009, J IMMUNOL, V182, P4056, DOI 10.4049/jimmunol.0801875
   Porter CM, 2018, PROSTATE CANCER P D, V21, P345, DOI 10.1038/s41391-018-0041-1
   Powell DW, 1999, AM J PHYSIOL-CELL PH, V277, pC1, DOI 10.1152/ajpcell.1999.277.1.C1
   PRICE H, 1990, HUM PATHOL, V21, P578, DOI 10.1016/S0046-8177(96)90002-7
   Pyun JH, 2017, KAOHSIUNG J MED SCI, V33, P458, DOI 10.1016/j.kjms.2017.06.010
   Quillard T, 2013, INT J MOL SCI, V14, P6863, DOI 10.3390/ijms14046863
   Robert G, 2009, PROSTATE, V69, P1774, DOI 10.1002/pros.21027
   Roehrborn CG, 2008, INT J IMPOT RES, V20, pS11, DOI 10.1038/ijir.2008.55
   Roehrborn CG, 2002, UROLOGY, V60, P434, DOI 10.1016/S0090-4295(02)01905-2
   Roehrborn Claus G, 2005, Rev Urol, V7 Suppl 9, pS3
   Roumenina LT, 2019, CANCER IMMUNOL RES, V7, P1091, DOI 10.1158/2326-6066.CIR-18-0891
   Rowley DR, 1998, CANCER METAST REV, V17, P411, DOI 10.1023/A:1006129420005
   Saito M, 2014, SCI REP-UK, V4, DOI 10.1038/srep03822
   Sampson N, 2012, OXID MED CELL LONGEV, V2012, DOI 10.1155/2012/458276
   Schauer IG, 2008, UROLOGY, V72, P205, DOI 10.1016/j.urology.2007.11.083
   Schauer IG, 2009, PROSTATE, V69, P373, DOI 10.1002/pros.20886
   Sciarra A, 2008, J STEROID BIOCHEM, V108, P254, DOI 10.1016/j.jsbmb.2007.09.013
   Shang YL, 2016, PROTEIN CELL, V7, P159, DOI 10.1007/s13238-016-0250-0
   Shaw A, 2007, J UROLOGY, V177, P832, DOI 10.1016/j.juro.2006.10.061
   Steiner GE, 2003, LAB INVEST, V83, P1131, DOI 10.1097/01.LAB.0000081388.40145.65
   Sutcliffe S, 2006, CANCER EPIDEM BIOMAR, V15, P939, DOI 10.1158/1055-9965.EPI-05-0781
   TAGUCHI O, 1987, J EXP MED, V165, P146, DOI 10.1084/jem.165.1.146
   Takezawa K, 2021, PROSTATE, V81, P1287, DOI 10.1002/pros.24223
   Tong Y, 2020, MEDIAT INFLAMM, V2020, DOI 10.1155/2020/7958316
   Tubaro A, 2015, EUR UROL, V67, P271, DOI 10.1016/j.eururo.2014.10.016
   Tuxhorn JA, 2002, CLIN CANCER RES, V8, P2912
   Untergasser G, 2005, EXP GERONTOL, V40, P121, DOI 10.1016/j.exger.2004.12.008
   Urisman A, 2006, PLOS PATHOG, V2, P211, DOI 10.1371/journal.ppat.0020025
   Vezina Chad M, 2007, Curr Urol Rep, V8, P275, DOI 10.1007/s11934-007-0073-x
   Vickman RE, 2022, NAT COMMUN, V13, DOI 10.1038/s41467-022-29719-1
   Vignozzi L, 2014, J ENDOCRINOL INVEST, V37, P313, DOI 10.1007/s40618-014-0051-3
   Vignozzi L, 2013, PROSTATE, V73, P1391, DOI 10.1002/pros.22686
   Vital P, 2016, PROSTATE, V76, P58, DOI 10.1002/pros.23100
   Wang XH, 2012, J BIOL CHEM, V287, P18376, DOI 10.1074/jbc.M112.355164
   Wang Z, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24054911
   Zenzmaier C, 2013, PROSTATE, V73, P1441, DOI 10.1002/pros.22691
   Zuo L, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20184472
NR 118
TC 16
Z9 17
U1 0
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL
PY 2023
VL 24
IS 14
AR 11634
DI 10.3390/ijms241411634
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA N3GW5
UT WOS:001035948300001
PM 37511400
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Derrick, SA
   Kristo, AS
   Reaves, SK
   Sikalidis, AK
AF Derrick, Stefani A.
   Kristo, Aleksandra S.
   Reaves, Scott K.
   Sikalidis, Angelos K.
TI Effects of Dietary Red Raspberry Consumption on Pre-Diabetes and Type 2
   Diabetes Mellitus Parameters
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Review
DE red raspberries; western diet; type 2 diabetes mellitus; pre-diabetes;
   metabolic syndrome
ID GUT MICROBIOTA; HEALTH; STRESS; BIOMARKERS; BERRIES; KETONE; LIVER;
   FRUIT; RISK
AB Type 2 diabetes mellitus (T2DM) is a chronic metabolic condition characterized by glucose clearance abnormalities and insufficient insulin response. Left uncontrolled, T2DM can result in serious complications and death. With no cure available currently and the prevalence of major risk factors such as pre-diabetes and the metabolic syndrome continuously increasing, there is an urgent need for effective treatments with limited or no side effects. Red raspberries (RR) contain various phytonutrients with potential for modulating insulin function, glucose, and lipid metabolism. The objective of this literature review was to investigate the potential metabolic benefits of dietary RR in individuals with T2DM and pre-diabetes. A search of major scientific databases was employed to identify peer-reviewed, in vivo, or human studies that utilized whole RR or its functional constituents as treatment. The studies examined provide evidence that RR may offer clinically beneficial effects for the prevention and management of chronic diseases through improvements in glucose handling and insulin sensitivity, adiposity, lipid profiles, ectopic lipid accumulation, inflammation, oxidative stress, and cardiac health. More human trials and in vivo studies are needed to confirm the benefits of dietary RR in T2DM and pre-diabetes and to explore the dose-dependent relationships, optimal duration, and treatment modality.
C1 [Derrick, Stefani A.; Kristo, Aleksandra S.; Reaves, Scott K.; Sikalidis, Angelos K.] Calif Polytech State Univ San Luis Obispo, Dept Food Sci & Nutr, 1 Grand Ave, San Luis Obispo, CA 93407 USA.
C3 California State University System; California Polytechnic State
   University San Luis Obispo
RP Sikalidis, AK (corresponding author), Calif Polytech State Univ San Luis Obispo, Dept Food Sci & Nutr, 1 Grand Ave, San Luis Obispo, CA 93407 USA.
EM sderrick@calpoly.edu; akristo@calpoly.edu; sreaves@calpoly.edu;
   asikalid@calpoly.edu
RI Kristo, Aleksandra/AHC-3770-2022; Sikalidis, Angelos/L-4690-2019
OI Kristo, Aleksandra S./0000-0002-0733-4041; Derrick,
   Stefani/0000-0001-5792-8385; Sikalidis, Angelos/0000-0003-3487-4120
FU California State University Agriculture Research Institute (ARI)
   [20-03-120]
FX Partial funding for this project has been made available by the
   California State University Agriculture Research Institute (ARI).
   Funding was through ARI seed grant #20-03-120, awarded to Angelos K.
   Sikalidis.
CR American Diabetes Association (ADA), BURD DIAB CAL
   [Anonymous], 2015, DIABETES CARE, V38, pS8, DOI 10.2337/dc15-S005
   Attia RT, 2019, BIOMED PHARMACOTHER, V110, P500, DOI 10.1016/j.biopha.2018.11.079
   Babey Susan H, 2016, Policy Brief UCLA Cent Health Policy Res, P1
   Basu A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11091983
   Burton-Freeman BM, 2016, ADV NUTR, V7, P44, DOI 10.3945/an.115.009639
   Calvano A, 2019, FOOD FUNCT, V10, P6227, DOI [10.1039/C9FO01426H, 10.1039/c9fo01426h]
   Cefalu WT, 2019, DIABETES CARE, V42, pS90, DOI 10.2337/dc19-S009
   Chalasani N, 2012, HEPATOLOGY, V55, P2005, DOI 10.1002/hep.25762
   Cheang KI, 2016, OBSTET GYNECOL, V128, P1421, DOI 10.1097/AOG.0000000000001757
   FAO, FOOD LAND AGR ORG UN
   González-Barrio R, 2011, DRUG METAB DISPOS, V39, P1680, DOI 10.1124/dmd.111.039651
   Goodman RS, 2018, ROUT RES JOURNALISM, P1
   Grussu D, 2011, J AGR FOOD CHEM, V59, P2324, DOI 10.1021/jf1045359
   Harris MF, 2013, AUST FAM PHYSICIAN, V42, P524
   Hur KY, 2015, DIABETES METAB J, V39, P198
   Jennings A, 2014, J NUTR, V144, P202, DOI 10.3945/jn.113.184358
   Jia H, 2011, PHARMACOGN MAG, V7, P19, DOI 10.4103/0973-1296.75885
   Kang I, 2016, J NUTR BIOCHEM, V32, P64, DOI 10.1016/j.jnutbio.2016.02.006
   Karuranga S., 2019, IDF Diabetes Atlas, V9th
   Khoo HE, 2017, FOOD NUTR RES, V61, P1, DOI 10.1080/16546628.2017.1361779
   Kirakosyan A, 2018, J FUNCT FOODS, V41, P83, DOI 10.1016/j.jff.2017.12.033
   Koss-Mikolajczyk I, 2019, FOODS, V8, DOI 10.3390/foods8120646
   Kristo AS, 2016, ANTIOXIDANTS-BASEL, V5, DOI 10.3390/antiox5040037
   Kshatriya D, 2019, NUTR RES, V68, P19, DOI 10.1016/j.nutres.2019.05.005
   Lee WJ, 2010, J VASC SURG, V52, P1290, DOI 10.1016/j.jvs.2010.04.085
   Luo T, 2017, FOOD FUNCT, V8, P4081, DOI [10.1039/C7FO00702G, 10.1039/c7fo00702g]
   Madic V, 2021, J ETHNOPHARMACOL, V265, DOI 10.1016/j.jep.2020.113210
   Makki K, 2018, CELL HOST MICROBE, V23, P705, DOI 10.1016/j.chom.2018.05.012
   Mehanna ET, 2018, EUR J PHARMACOL, V832, P81, DOI 10.1016/j.ejphar.2018.05.028
   Moruzzi M, 2021, MOLECULES, V26, DOI 10.3390/molecules26051403
   Neveu V, 2010, DATABASE-OXFORD, DOI 10.1093/database/bap024
   Noratto G, 2016, FOOD FUNCT, V7, P4944, DOI [10.1039/c6fo01330a, 10.1039/C6FO01330A]
   Noratto GD, 2017, FOOD CHEM, V227, P305, DOI 10.1016/j.foodchem.2017.01.097
   Panchal SK, 2011, J BIOMED BIOTECHNOL, DOI 10.1155/2011/351982
   Papatheodorou K, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/189525
   Psaltopoulou T, 2011, NUTR METAB CARDIOVAS, V21, P561, DOI 10.1016/j.numecd.2009.11.005
   Puupponen-Pimiä R, 2013, MOL NUTR FOOD RES, V57, P2258, DOI 10.1002/mnfr.201300280
   Saeedi P, 2020, DIABETES RES CLIN PR, V162, DOI 10.1016/j.diabres.2020.108086
   Schell J, 2019, ANN NUTR METAB, V74, P165, DOI 10.1159/000497226
   Seeram NP, 2018, FOOD FUNCT, V9, P20, DOI 10.1039/c7fo90053h
   Suvarna R, 2020, J AYURVEDA INTEGR ME, V12, P213, DOI 10.1016/j.jaim.2020.11.002
   Torres-Fuentes C, 2019, FASEB J, V33, P13546, DOI 10.1096/fj.201901433R
   Törrönen R, 2013, J NUTR, V143, P430, DOI 10.3945/jn.112.169771
   Tu LJ, 2019, FOOD CHEM TOXICOL, V133, DOI 10.1016/j.fct.2019.110796
   U.S. Department of Health and Human Services, 2020, DIET GUID AM 2020 20, V9th ed.
   United States Department of Agriculture (USDA), MILK FOODD CLENTR
   US Department of Health and Human Services Centers for Disease Control and Prevention, 2020, NAT DIAB STAT REP 20
   VandenAkker NE, 2021, J MED FOOD, V24, P817, DOI 10.1089/jmf.2020.0130
   Vara AL, 2020, FOODS, V9, DOI 10.3390/foods9111522
   Wang LL, 2012, J MED FOOD, V15, P495, DOI 10.1089/jmf.2011.1717
   Weiskirchen R, 2019, MOL ASPECTS MED, V65, P2, DOI 10.1016/j.mam.2018.06.003
   World Health Organization, Fact Sheet: Diabetes
   Xiao D, 2019, OBESITY, V27, P542, DOI 10.1002/oby.22406
   Xing T, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201701035
   Xiong SL, 2018, INT J BIOL MACROMOL, V113, P212, DOI 10.1016/j.ijbiomac.2018.02.124
   Yang LP, 2017, ADV NUTR, V8, P684, DOI 10.3945/an.116.014852
   Zhao L, 2018, NUTR DIABETES, V8, DOI 10.1038/s41387-018-0049-6
   Zhu MJ, 2018, J NUTR BIOCHEM, V53, P96, DOI 10.1016/j.jnutbio.2017.10.012
   Zou TD, 2018, J NUTR BIOCHEM, V55, P157, DOI 10.1016/j.jnutbio.2018.02.005
NR 60
TC 23
Z9 25
U1 3
U2 43
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD SEP
PY 2021
VL 18
IS 17
AR 9364
DI 10.3390/ijerph18179364
PG 20
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA UN5LL
UT WOS:000694057900001
PM 34501954
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lucchetti, BFC
   Boaretto, N
   Lopes, FNC
   Malvezi, AD
   Lovo-Martins, MI
   Tatakihara, VLH
   Fattori, V
   Pereira, RS
   Verri, WA
   Araujo, EJD
   Pinge, P
   Martins-Pinge, MC
AF Cruz Lucchetti, Bruno Fernando
   Boaretto, Natalia
   Cortegoso Lopes, Fernanda Novi
   Malvezi, Aparecida Donizette
   Lovo-Martins, Maria Isabel
   Hideko Tatakihara, Vera Lucia
   Fattori, Victor
   Pereira, Rito Santo
   Verri, Waldiceu Aparecido, Jr.
   de Almeida Araujo, Eduardo Jose
   Pinge-Filho, Phileno
   Martins-Pinge, Marli Cardoso
TI Metabolic syndrome agravates cardiovascular, oxidative and inflammatory
   dysfunction during the acute phase of Trypanosoma cruzi infection
   in mice
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ADIPOSE-TISSUE; CHAGAS-DISEASE; NITRIC-OXIDE; INSULIN-RESISTANCE;
   INTRAVENOUS GLUCOSE; CYTOKINE PRODUCTION; BLOOD-GLUCOSE; OBESITY;
   STRESS; EXPRESSION
AB We evaluated the influence of metabolic syndrome (MS) on acute Trypanosoma cruzi infection. Obese Swiss mice, 70 days of age, were subjected to intraperitoneal infection with 5 x 10(2) trypomastigotes of the Y strain. Cardiovascular, oxidative, inflammatory, and metabolic parameters were evaluated in infected and non-infected mice. We observed higher parasitaemia in the infected obese group (IOG) than in the infected control group (ICG) 13 and 15 days post-infection. All IOG animals died by 19 days post-infection (dpi), whereas 87.5% of the ICG survived to 30 days. Increased plasma nitrite levels in adipose tissue and the aorta were observed in the IOG. Higher INF-(gamma) and MCP-1 concentrations and lower IL-10 concentrations were observed in the IOG compared to those in the ICG. Decreased insulin sensitivity was observed in obese animals, which was accentuated after infection. Higher parasitic loads were found in adipose and hepatic tissue, and increases in oxidative stress in cardiac, hepatic, and adipose tissues were characteristics of the IOG group. Thus, MS exacerbates experimental Chagas disease, resulting in greater damage and decreased survival in infected animals, and might be a warning sign that MS can influence other pathologies.
C1 [Cruz Lucchetti, Bruno Fernando; Boaretto, Natalia; Cortegoso Lopes, Fernanda Novi; Martins-Pinge, Marli Cardoso] Univ Estadual Londrina, Ctr Biol Sci, Dept Physiol Sci, Londrina, PR, Brazil.
   [Malvezi, Aparecida Donizette; Lovo-Martins, Maria Isabel; Hideko Tatakihara, Vera Lucia; Fattori, Victor; Pereira, Rito Santo; Verri, Waldiceu Aparecido, Jr.; Pinge-Filho, Phileno] Univ Estadual Londrina, Ctr Biol Sci, Dept Pathol Sci, Londrina, PR, Brazil.
   [de Almeida Araujo, Eduardo Jose] Univ Estadual Londrina, Ctr Biol Sci, Dept Histol, Londrina, PR, Brazil.
   [Cruz Lucchetti, Bruno Fernando] Univ Ctr Araguaia Valley, Dept Physiotherapy, Barra Do Garcas, MT, Brazil.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   Universidade Estadual de Londrina
RP Martins-Pinge, MC (corresponding author), Univ Estadual Londrina, Ctr Biol Sci, Dept Physiol Sci, Londrina, PR, Brazil.
EM martinspinge@uel.br
RI Pinge-Filho, Phileno/G-2844-2012; Fattori, Victor/C-2745-2016; Pereira,
   Rito/KIC-7669-2024; Verri, Waldiceu/I-1330-2013; de Almeida Araujo,
   Eduardo Jose/D-2397-2010; Martins-Pinge, Marli Cardoso/C-4417-2014
OI Pereira, Rito/0000-0002-3963-2019; Verri, Waldiceu/0000-0003-2756-9283;
   Boaretto, Natalia/0000-0003-2472-0582; de Almeida Araujo, Eduardo
   Jose/0000-0002-8609-5041; Martins-Pinge, Marli
   Cardoso/0000-0002-9444-1530
FU CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior);
   CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
FX This study was supported by CAPES (Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior), for B.F.C.L., F.N.C.L. fellowship; CNPq
   (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) for the
   research fellows for W.A.V.J., P.P.F. and M.C.M.P. This research did not
   receive any specific grant from funding agencies in the public,
   commercial, or not-for-profit sectors.
CR Aballay LR, 2013, NUTR REV, V71, P168, DOI 10.1111/j.1753-4887.2012.00533.x
   Alvarez MN, 2004, ARCH BIOCHEM BIOPHYS, V432, P222, DOI 10.1016/j.abb.2004.09.015
   Andrade DV, 2014, PLOS NEGLECT TROP D, V8, DOI 10.1371/journal.pntd.0003010
   Andreazzi AE, 2009, J ENDOCRINOL, V201, P351, DOI 10.1677/JOE-08-0312
   Andrews NW, 2012, J CLIN INVEST, V122, P2352, DOI 10.1172/JCI64239
   Velásquez AMA, 2014, BIOORG MED CHEM LETT, V24, P1707, DOI 10.1016/j.bmcl.2014.02.046
   BERNARDIS LL, 1968, J ENDOCRINOL, V40, P527, DOI 10.1677/joe.0.0400527
   BRENER Z., 1962, REV INST MED TROP SAO PAULO, V4, P389
   Brima W, 2015, DIABETES-METAB RES, V31, P346, DOI 10.1002/dmrr.2636
   BROWN MS, 1975, CELL, V6, P307, DOI 10.1016/0092-8674(75)90182-8
   Cabalén ME, 2016, ONCOTARGET, V7, P13400, DOI 10.18632/oncotarget.7630
   Cardoni RL, 1997, AM J TROP MED HYG, V56, P329, DOI 10.4269/ajtmh.1997.56.329
   Chandra M, 2002, INT J PARASITOL, V32, P897, DOI 10.1016/S0020-7519(02)00028-0
   Coelho C. F. F., 2018, EARLY ONSET PROGR NO, P1, DOI [10.1017/s2040174418000284, DOI 10.1017/S2040174418000284]
   Combs TP, 2005, J BIOL CHEM, V280, P24085, DOI 10.1074/jbc.M412802200
   Cunha NV, 2010, LIFE SCI, V87, P375, DOI 10.1016/j.lfs.2010.07.014
   da Cunha NV, 2017, CLIN EXP HYPERTENS, V39, P50, DOI 10.1080/10641963.2016.1210628
   da Cunha NV, 2014, AM J PHYSIOL-HEART C, V306, DOI 10.1152/ajpheart.00520.2013
   DAWSON R, 1989, PHARMACOL BIOCHEM BE, V32, P391, DOI 10.1016/0091-3057(89)90168-8
   Dawson R., 1983, NEUROBEHAVIORAL TOXI
   de Almeida LA, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023135
   de Almeida-Leite CM, 2007, NEUROBIOL DIS, V25, P170, DOI 10.1016/j.nbd.2006.09.003
   de Almeida-Leite CM, 2014, MEM I OSWALDO CRUZ, V109, P459, DOI 10.1590/0074-0276130492
   De Lorenzo A, 2007, AM J CLIN NUTR, V85, P40, DOI 10.1093/ajcn/85.1.40
   Deveaux V, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005844
   Drewnowski A, 1997, NUTR REV, V55, P31, DOI 10.1111/j.1753-4887.1997.tb01593.x
   Fan W, 1997, NATURE, V385, P165, DOI 10.1038/385165a0
   Fantuzzi G, 2005, J ALLERGY CLIN IMMUN, V115, P911, DOI 10.1016/j.jaci.2005.02.023
   Fattori V, 2017, PHARMACOL RES, V120, P10, DOI 10.1016/j.phrs.2016.12.039
   Fattori V, 2017, J DRUG TARGET, V25, P264, DOI 10.1080/1061186X.2016.1245308
   Fattori V, 2015, INFLAMM RES, V64, P993, DOI 10.1007/s00011-015-0885-y
   Finzi JK, 2004, MOL BIOCHEM PARASIT, V133, P37, DOI 10.1016/j.molbiopara.2003.08.011
   Furuya DT, 2010, METABOLISM, V59, P395, DOI 10.1016/j.metabol.2009.08.011
   Garcia MN, 2017, INFECT GENET EVOL, V49, P151, DOI 10.1016/j.meegid.2017.01.016
   Garcia-Macedo R, 2008, EUR J PHARMACOL, V587, P317, DOI 10.1016/j.ejphar.2008.03.051
   Geloneze Bruno, 2006, Arq Bras Endocrinol Metab, V50, P208, DOI 10.1590/S0004-27302006000200007
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   GUARIENTO ME, 1993, BRAZ J MED BIOL RES, V26, P491
   Bautista RJH, 2019, BIOMED PHARMACOTHER, V111, P503, DOI 10.1016/j.biopha.2018.12.108
   Hirata AE, 1997, BRAZ J MED BIOL RES, V30, P671, DOI 10.1590/S0100-879X1997000500016
   Hölscher C, 2000, INFECT IMMUN, V68, P4075, DOI 10.1128/IAI.68.7.4075-4083.2000
   Hui H, 2017, MOL MED REP, V16, P8062, DOI 10.3892/mmr.2017.7587
   Juge-Aubry CE, 2002, MOL CELL ENDOCRINOL, V194, P1, DOI 10.1016/S0303-7207(02)00191-0
   Karlen-Amarante M, 2012, METABOLISM, V61, P1435, DOI 10.1016/j.metabol.2012.03.005
   KIERSZENBAUM F, 1974, J IMMUNOL, V112, P1839
   Kizer J. S., 1978, PHARMACOL REV, V29, P301
   Kleiner S, 2018, P NATL ACAD SCI USA, V115, pE7642, DOI 10.1073/pnas.1721418115
   Krauth-Siegel RL, 2008, BBA-GEN SUBJECTS, V1780, P1236, DOI 10.1016/j.bbagen.2008.03.006
   LEFLOCH JP, 1990, DIABETES CARE, V13, P172, DOI 10.2337/diacare.13.2.172
   Lenz A, 2008, CURR OPIN ENDOCRINOL, V15, P9, DOI 10.1097/MED.0b013e3282f43a5b
   Lizardo K, 2017, PARASITOL RES, V116, P711, DOI 10.1007/s00436-016-5337-2
   Lopez-Jaramillo P, 2014, ARQ BRAS ENDOCRINOL, V58, P205, DOI 10.1590/0004-2730000003019
   Lu X Y, 2001, Psychopharmacol Bull, V35, P45
   Lucchetti BFC, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00315
   LUNDBAEK K, 1962, BRIT MED J, P1507, DOI 10.1136/bmj.1.5291.1507
   Martin JM, 2016, INT J ENDOCRINOL, V2016, DOI 10.1155/2016/9242319
   MOILANEN E, 1995, ANN MED, V27, P359, DOI 10.3109/07853899509002589
   Nagajyothi F, 2008, OBESITY, V16, P1992, DOI 10.1038/oby.2008.331
   Nagajyothi F, 2014, PLOS NEGLECT TROP D, V8, DOI 10.1371/journal.pntd.0003118
   Nagajyothi F, 2013, AM J PATHOL, V182, P886, DOI 10.1016/j.ajpath.2012.11.027
   Nagajyothi F, 2012, J INFECT DIS, V205, P830, DOI 10.1093/infdis/jir840
   Nagajyothi F, 2011, PLOS NEGLECT TROP D, V5, DOI 10.1371/journal.pntd.0000953
   Nagajyothi F, 2010, J INFECT DIS, V202, P1104, DOI 10.1086/656189
   Nagajyothi F, 2009, MEM I OSWALDO CRUZ, V104, P219, DOI 10.1590/S0074-02762009000900028
   Nagy C, 2018, JOVE-J VIS EXP, DOI 10.3791/56672
   Navarro-Gonzálvez JA, 1998, CLIN CHEM, V44, P679
   Nguyen P, 2008, J ANIM PHYSIOL AN N, V92, P272, DOI 10.1111/j.1439-0396.2007.00752.x
   Alvarez MN, 2011, J BIOL CHEM, V286, P6627, DOI 10.1074/jbc.M110.167247
   OLIVEIRA LCM, 1993, BRAZ J MED BIOL RES, V26, P1187
   Paiva CN, 2012, J CLIN INVEST, V122, P2531, DOI 10.1172/JCI58525
   Panis C, 2011, EXP PARASITOL, V127, P58, DOI 10.1016/j.exppara.2010.06.030
   Pausova Z, 2006, CURR OPIN NEPHROL HY, V15, P173, DOI 10.1097/01.mnh.0000214775.42103.a5
   Pérez-Molina JA, 2018, LANCET, V391, P82, DOI 10.1016/S0140-6736(17)31612-4
   Piacenza L, 2009, INT J PARASITOL, V39, P1455, DOI 10.1016/j.ijpara.2009.05.010
   Piacenza L, 2008, BIOCHEM J, V410, P359, DOI 10.1042/BJ20071138
   Piacenza L, 2009, CURR OPIN MICROBIOL, V12, P415, DOI 10.1016/j.mib.2009.06.011
   Queme LF, 2016, J NEUROSCI, V36, P19, DOI 10.1523/JNEUROSCI.2856-15.2016
   REED SG, 1994, J IMMUNOL, V153, P3135
   Rocha Rodrigues Denise Bertulucci, 2012, Clin Dev Immunol, V2012, P361730, DOI 10.1155/2012/361730
   Roffê E, 2012, J IMMUNOL, V188, P649, DOI 10.4049/jimmunol.1003845
   Roman-Ramos R, 2011, BASIC CLIN PHARMACOL, V108, P406, DOI 10.1111/j.1742-7843.2011.00671.x
   Rudich A, 2007, TRENDS ENDOCRIN MET, V18, P291, DOI 10.1016/j.tem.2007.08.006
   Santiago HC, 2012, PLOS NEGLECT TROP D, V6, DOI 10.1371/journal.pntd.0001492
   Schijman AG, 2018, ACTA TROP, V184, P59, DOI 10.1016/j.actatropica.2018.02.019
   Swinburn BA, 2011, LANCET, V378, P804, DOI 10.1016/S0140-6736(11)60813-1
   Tadic M, 2013, EUR J INTERN MED, V24, P608, DOI 10.1016/j.ejim.2013.08.007
   TANAKA Y, 1983, INFECT IMMUN, V41, P1322, DOI 10.1128/IAI.41.3.1322-1331.1983
   Tanowitz HB, 2011, ADV PARASIT, V76, P235, DOI 10.1016/B978-0-12-385895-5.00010-4
   Tarleton RL, 2007, CURR OPIN IMMUNOL, V19, P430, DOI 10.1016/j.coi.2007.06.003
   Tsuneyama K, 2017, PATHOL INT, V67, P539, DOI 10.1111/pin.12600
   WHO, 2012, WORLD MALARIA REPORT 2012, P1
   Who, 2017, WHO CHAG DIS AM TRYP
   Yaman H, 2013, EXP TOXICOL PATHOL, V65, P147, DOI 10.1016/j.etp.2011.07.003
   Zago Anderson Saranz, 2006, Arq. Bras. Cardiol., V87, pe264, DOI 10.1590/S0066-782X2006001900029
   Zhao DZ, 2016, MICROBES INFECT, V18, P675, DOI 10.1016/j.micinf.2016.06.006
NR 95
TC 16
Z9 17
U1 0
U2 1
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 11
PY 2019
VL 9
AR 18885
DI 10.1038/s41598-019-55363-9
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA JV8TB
UT WOS:000502632400001
PM 31827186
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yen, CH
   Yang, NC
   Lee, BJ
   Lin, JY
   Hsia, S
   Lin, PT
AF Yen, Chi-Hua
   Yang, Nae-Cherng
   Lee, Bor-Jen
   Lin, Jui-Yuan
   Hsia, Simon
   Lin, Ping-Ting
TI The Antioxidant Status and Concentrations of Coenzyme Q10 and Vitamin E
   in Metabolic Syndrome
SO SCIENTIFIC WORLD JOURNAL
LA English
DT Article
ID 3RD NATIONAL-HEALTH; OXIDATIVE STRESS; DIABETES-MELLITUS; NUTRITION;
   SUPPLEMENTATION; HYPERTENSION; ASSOCIATION; POPULATION; PREVALENCE;
   PLASMA
AB The purpose of this study was to investigate the levels of coenzyme Q10 and vitamin E and the antioxidant status in subjects with metabolic syndrome (MS). Subjects with MS (n = 72) were included according to the criteria for MS. The non-MS group (n = 105) was comprised of healthy individuals with normal blood biochemical values. The plasma coenzyme Q10, vitamin E concentrations, lipid profiles, and antioxidant enzymes levels (catalase, superoxide dismutase, and glutathione peroxidase) were measured. The subjects with MS had significantly higher concentrations of plasma coenzyme Q10 and vitamin E than those in the non-MS group, but these differences were not significant after being normalized for triglyceride level. The levels of antioxidant enzymes were significantly lower in the MS group than in the non-MS group. The subjects with the higher antioxidant enzymes activities had significant reductions in the risk of MS (P < 0.01) after being adjusted for coenzyme Q10 and vitamin E. In conclusion, the subjects with MS might be under higher oxidative stress resulting in low levels of antioxidant enzyme activities. A higher level of antioxidant enzymes activities was significantly associated with a reduction in the risk of MS independent of the levels of coenzyme Q10 and vitamin E.
C1 [Yen, Chi-Hua] Chung Shan Med Univ Hosp, Dept Family & Community Med, Taichung 40201, Taiwan.
   [Yen, Chi-Hua] Chung Shan Med Univ, Sch Med, Taichung 40201, Taiwan.
   [Yen, Chi-Hua] Chung Shan Med Univ, Ctr Educ & Res Geriatr & Gerontol, Taichung 40201, Taiwan.
   [Yang, Nae-Cherng; Lin, Jui-Yuan; Lin, Ping-Ting] Chung Shan Med Univ, Sch Nutr, Taichung 40201, Taiwan.
   [Yang, Nae-Cherng; Lin, Ping-Ting] Chung Shan Med Univ Hosp, Dept Nutr, Taichung 40201, Taiwan.
   [Lee, Bor-Jen] Taichung Vet Gen Hosp, Intens Care Unit, Taichung 40705, Taiwan.
   [Hsia, Simon] Hungkuang Univ, Dept Nutr, Taichung 43346, Taiwan.
   [Hsia, Simon] Hungkuang Univ, Inst Biomed Nutr, Taichung 43346, Taiwan.
C3 Chung Shan Medical University; Chung Shan Medical University Hospital;
   Chung Shan Medical University; Chung Shan Medical University; Chung Shan
   Medical University; Chung Shan Medical University; Chung Shan Medical
   University Hospital; Taichung Veterans General Hospital; Hungkuang
   University; Hungkuang University
RP Lin, PT (corresponding author), Chung Shan Med Univ, Sch Nutr, Taichung 40201, Taiwan.
EM apt810@csmu.edu.tw
RI Yang, Nae-Cherng/ADE-3580-2022; Stefanadis, Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454
FU National Science Council, Taiwan [NSC 99-2320-B-040-011]
FX This study was supported by a grant from the National Science Council
   (NSC 99-2320-B-040-011), Taiwan. The authors would like to express their
   sincere appreciation to the subjects for their participation. They thank
   the nurses at the Chung Shan Medical University Hospital for providing
   expert assistance in blood sample collection and data analysis.
CR Aebi H, 1984, Methods Enzymol, V105, P121
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   ALLEVA R, 1995, P NATL ACAD SCI USA, V92, P9388, DOI 10.1073/pnas.92.20.9388
   [Anonymous], TAIWAN J GERIATR GER
   Antoniades C, 2003, HERZ, V28, P628, DOI 10.1007/s00059-003-2417-8
   Bhagavan HN, 2006, FREE RADICAL RES, V40, P445, DOI 10.1080/10715760600617843
   CERIELLO A, 1993, DIABETOLOGIA, V36, P265, DOI 10.1007/BF00399961
   Chen KJ, 2011, ASIA PAC J CLIN NUTR, V20, P275
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Czernichow S, 2009, AM J CLIN NUTR, V90, P329, DOI 10.3945/ajcn.2009.27635
   ERNSTER L, 1995, BBA-MOL BASIS DIS, V1271, P195, DOI 10.1016/0925-4439(95)00028-3
   FERRANNINI E, 1991, DIABETOLOGIA, V34, P416, DOI 10.1007/BF00403180
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Ford ES, 2003, DIABETES CARE, V26, P575, DOI 10.2337/diacare.26.3.575
   Giugliano D, 2000, NUTR METAB CARDIOVAS, V10, P38
   GIUGLIANO D, 1995, METABOLISM, V44, P363, DOI 10.1016/0026-0495(95)90167-1
   American Heart Association, 2005, Cardiol Rev, V13, P322
   HATAM LJ, 1979, J LIPID RES, V20, P639
   Karaouzene N, 2011, NUTR METAB CARDIOVAS, V21, P792, DOI 10.1016/j.numecd.2010.02.007
   Lee BJ, 2012, SCI WORLD J, DOI 10.1100/2012/792756
   Littarru G.P., 2007, U.S. Patent, Patent No. 7303921
   Mabuchi H, 2005, J ATHEROSCLER THROMB, V12, P111, DOI 10.5551/jat.12.111
   MARKLUND S, 1974, EUR J BIOCHEM, V47, P469
   Miles MV, 2003, CLIN CHIM ACTA, V332, P123, DOI 10.1016/S0009-8981(03)00137-2
   MOHR D, 1994, ARTERIOSCLER THROMB, V14, P1186, DOI 10.1161/01.ATV.14.7.1186
   PAGLIA DE, 1967, J LAB CLIN MED, V70, P158
   Pan WH, 2011, ASIA PAC J CLIN NUTR, V20, P238
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Penckofer Sue, 2002, J Cardiovasc Nurs, V16, P68
   Pravst I, 2010, CRIT REV FOOD SCI, V50, P269, DOI 10.1080/10408390902773037
   Singh U, 2007, NUTR REV, V65, P286, DOI [10.1301/nr.2007.jun.286-293, 10.1111/j.1753-4887.2007.tb00306.x]
   Stocker R, 2004, PHYSIOL REV, V84, P1381, DOI 10.1152/physrev.00047.2003
   West IC, 2000, DIABETIC MED, V17, P171, DOI 10.1046/j.1464-5491.2000.00259.x
NR 33
TC 9
Z9 10
U1 0
U2 6
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1537-744X
J9 SCI WORLD J
JI Sci. World J.
PY 2013
AR 767968
DI 10.1155/2013/767968
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 218GL
UT WOS:000324420700001
PM 24082857
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Cannizzo, B
   Luján, A
   Estrella, N
   Lembo, C
   Cruzado, M
   Castro, C
AF Cannizzo, Beatriz
   Lujan, Agustin
   Estrella, Natalia
   Lembo, Carina
   Cruzado, Montserrat
   Castro, Claudia
TI Insulin Resistance Promotes Early Atherosclerosis via Increased
   Proinflammatory Proteins and Oxidative Stress in Fructose-Fed ApoE-KO
   Mice
SO EXPERIMENTAL DIABETES RESEARCH
LA English
DT Article
ID RENIN-ANGIOTENSIN SYSTEM; MATRIX METALLOPROTEINASES;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; NADPH OXIDASE; INFLAMMATION;
   ACTIVATION; EXPRESSION; VCAM-1; MODEL
AB High fructose intake induces an insulin resistance state associated with metabolic syndrome (MS). The effect of vascular inflammation in this model is not completely addressed. The aim of this study was to evaluate vascular remodeling, inflammatory and oxidative stress markers, and atheroma development in high-fructose diet-induced insulin resistance of ApoE-deficient mice (ApoE-KO). Mice were fed with either a normal chow or a 10% w/v fructose (HF) in drinking water over a period of 8 weeks. Thereafter, plasma metabolic parameters, vascular remodeling, atheroma lesion size, inflammatory markers, and NAD(P) H oxidase activity in the arteries were determined. HF diet induced a marked increase in plasma glucose, insulin, and triglycerides in ApoE-KO mice, provoked vascular remodeling, enhanced expression of vascular cell-adhesion molecule-1 (VCAM-1) and matrix metalloprotease 9 (MMP-9) and enlarged atherosclerotic lesion in aortic and carotid arteries. NAD(P) H oxidase activity was enhanced by fructose intake, and this effect was attenuated by tempol, a superoxide dismutase mimetic, and losartan, an Angiotensin II receptor antagonist. Our study results show that high-fructose-induced insulin resistance promotes a proinflammatory and prooxidant state which accelerates atherosclerotic plaque formation in ApoE-KO mice.
C1 [Cannizzo, Beatriz; Lujan, Agustin; Estrella, Natalia; Cruzado, Montserrat; Castro, Claudia] Univ Nacl Cuyo, Lab Vasc Biol, Fac Med Sci, Inst Med & Expt Biol Cuyo IMBECU CONICET, RA-5500 Mendoza, Argentina.
   [Lembo, Carina] Univ Nacl Cuyo, Lab Cardiovasc Pathophysiol, Fac Med Sci, Inst Med & Expt Biol Cuyo IMBECU CONICET, RA-5500 Mendoza, Argentina.
C3 University Nacional Cuyo Mendoza; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); University Nacional Cuyo Mendoza
RP Castro, C (corresponding author), Univ Nacl Cuyo, Lab Vasc Biol, Fac Med Sci, Inst Med & Expt Biol Cuyo IMBECU CONICET, RA-5500 Mendoza, Argentina.
EM ccastro@fcm.uncu.edu.ar
RI Lujan, Agustín Leonardo/KII-7379-2024
OI Castro, Claudia/0000-0002-8428-2484; Lujan, Agustin
   Leonardo/0000-0003-4906-6951
FU Secretaria de Ciencia y Tecnica, Universidad Nacional de Cuyo [06/J246];
   CONICET; National Agency of Scientific and Technological Promotion
FX This work was supported by Grant 06/J246 (to M. Cruzado), 2007-2009 from
   Secretaria de Ciencia y Tecnica, Universidad Nacional de Cuyo. B.
   cannizzo is a recipient of a doctoral fellowship from CONICET, and C.
   Lembo is a recipient of a doctoral fellowship from National Agency of
   Scientific and Technological Promotion. The authors gratefully
   acknowledge the technical assistance of Mrs. Miriam Garcia and Miss.
   Analia Redondo.
CR Berg G, 2011, CLIN CHIM ACTA, V412, P1731, DOI 10.1016/j.cca.2011.06.013
   Castro C, 2004, ATHEROSCLEROSIS, V172, P31, DOI 10.1016/j.atherosclerosis.2003.09.003
   Collin B, 2007, MOL CELL BIOCHEM, V294, P225, DOI 10.1007/s11010-006-9263-y
   Deem TL, 2004, BLOOD, V104, P2385, DOI 10.1182/blood-2004-02-0665
   Delbosc S, 2005, ATHEROSCLEROSIS, V179, P43, DOI 10.1016/j.atherosclerosis.2004.10.018
   Fan AZ, 2006, J ATHEROSCLER THROMB, V13, P46, DOI 10.5551/jat.13.46
   Fearon IM, 2009, J MOL CELL CARDIOL, V47, P372, DOI 10.1016/j.yjmcc.2009.05.013
   Galkina E, 2007, ARTERIOSCL THROM VAS, V27, P2292, DOI 10.1161/ATVBAHA.107.149179
   Griendling KK, 2000, ARTERIOSCL THROM VAS, V20, P2175, DOI 10.1161/01.ATV.20.10.2175
   Ishibashi S, 2007, HYPERTENS RES, V30, P375, DOI 10.1291/hypres.30.375
   Kiechl S, 1999, ARTERIOSCL THROM VAS, V19, P1491, DOI 10.1161/01.ATV.19.6.1491
   Koh KK, 2009, CARDIOVASC RES, V81, P649, DOI 10.1093/cvr/cvn354
   Miatello Roberto, 2004, Current Vascular Pharmacology, V2, P371, DOI 10.2174/1570161043385510
   Muller G, 2009, ANTIOXID REDOX SIGN, V11, P1711, DOI [10.1089/ars.2008.2403, 10.1089/ARS.2008.2403]
   Nakashima Y, 1998, ARTERIOSCL THROM VAS, V18, P842, DOI 10.1161/01.ATV.18.5.842
   Peter K, 1999, Thromb Haemost, V82 Suppl 1, P38
   PIEDRAHITA JA, 1992, P NATL ACAD SCI USA, V89, P4471, DOI 10.1073/pnas.89.10.4471
   Puyo A. M., 2004, Autonomic & Autacoid Pharmacology, V24, P29, DOI 10.1111/j.1474-8673.2004.00313.x
   Reaven GM, 2003, J CLIN ENDOCR METAB, V88, P2399, DOI 10.1210/jc.2003-030087
   Schnee Siegfried, 2010, Cardiovasc Pathol, V19, pe195, DOI 10.1016/j.carpath.2009.10.001
   Schwartz EA, 2006, ENDOCRIN METAB CLIN, V35, P525, DOI 10.1016/j.ecl.2006.06.005
   Shin MH, 2008, FREE RADICAL BIO MED, V44, P635, DOI 10.1016/j.freeradbiomed.2007.10.053
   Shinozaki K, 2004, HYPERTENSION, V43, P255, DOI 10.1161/01.HYP.0000111136.86976.26
   Soliman A, 2008, CURR ATHEROSCLER REP, V10, P260, DOI 10.1007/s11883-008-0040-0
   Sorescu D, 2001, TRENDS CARDIOVAS MED, V11, P124, DOI 10.1016/S1050-1738(01)00097-4
   Wågsäter D, 2011, INT J MOL MED, V28, P247, DOI 10.3892/ijmm.2011.693
NR 26
TC 24
Z9 30
U1 0
U2 17
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-5214
EI 1687-5303
J9 EXP DIABETES RES
JI Exp. Diabetes Res.
PY 2012
AR 941304
DI 10.1155/2012/941304
PG 8
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA 924GQ
UT WOS:000302680200001
PM 22474431
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Krone, RE
   Ewer, AK
   Barrett, TG
   Moy, RJ
   Bakour, S
   Maher, ER
   Thangaratinam, S
   Cox, P
   Martin, B
   Khan, KS
   Zeegers, MP
AF Krone, Ruth E.
   Ewer, Andrew K.
   Barrett, Timothy G.
   Moy, Robert J.
   Bakour, Shagaf
   Maher, Eamonn R.
   Thangaratinam, Shakila
   Cox, Philip
   Martin, Bill
   Khan, Khalid S.
   Zeegers, Maurice P.
TI The Birmingham Registry for Twin and Heritability Studies (BiRTHS)
SO TWIN RESEARCH AND HUMAN GENETICS
LA English
DT Article
ID CORONARY-ARTERY-DISEASE; POSTNATAL DEPRESSION; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; POSTPARTUM DEPRESSION; CARDIOVASCULAR RISK; METABOLIC
   SYNDROME; MATERNAL OBESITY; PREVALENCE; WEIGHT
AB In this article we present the protocol of the Birmingham Registry for Twin Heritability Studies (BiRTHS), which aims to establish a long-term prospective twin registry with twins identified from the antenatal period and subjected to detailed follow-up. We plan to investigate the concordance in anthropometrics and early childhood phenotypes between 66 monozygotic and 154 dizygotic twin pairs in the first 2 years of recruitment. In this project we plan to determine the relative contributions of heritability and environment to fetal growth, birth size, growth in infancy and development up to 2 years of age in an ethnically mixed population. Twins will be assessed with the Griffitth's Mental Development Scales, which will enable us to obtain detailed information on development. As maternal depression may have an effect on the twins' neurodevelopment, the Edinburgh Postnatal Depression Scale will be used at various stages during pregnancy and after delivery to assess maternal depressive symptoms. The increasing prevalence of obesity in both adults and children has raised concerns about the effect of maternal obesity in pregnancy on fetal growth. The prospective study design gives us the opportunity to obtain data on maternal nutrition (reflected by body mass index) and ante- and postnatal growth and development of twins.
C1 Univ Birmingham, Dept Epidemiol & Publ Hlth, Unit Genet Epidemiol, Birmingham B15 2TT, W Midlands, England.
   Birmingham Womens Hosp, Neonatal Unit, Birmingham, W Midlands, England.
   Univ Birmingham, Inst Child Hlth, Birmingham B15 2TT, W Midlands, England.
   City Hosp, Dept Obstet & Gynaecol, Birmingham, W Midlands, England.
   Univ Birmingham, Sch Med, Dept Paediat & Child Hlth, Sect Med & Mol Genet, Birmingham, W Midlands, England.
   Birmingham Womens Hosp, Dept Obstet, Birmingham, W Midlands, England.
   Univ Birmingham, Dept Obstet & Gynecol, Birmingham, W Midlands, England.
C3 University of Birmingham; Birmingham Women's Hospital; University of
   Birmingham; University of Birmingham; University of Birmingham;
   Birmingham Women's Hospital; University of Birmingham
RP Zeegers, MP (corresponding author), Univ Birmingham, Dept Epidemiol & Publ Hlth, Unit Genet Epidemiol, Birmingham B15 2TT, W Midlands, England.
EM m.p.zeegers@bham.ac.uk
RI Ewer, Andrew/B-1050-2013; Thangaratinam, Shakila/AAP-3724-2021; Barrett,
   Timothy/F-1682-2010; Khan, Khalid Saeed/AAT-8824-2020
OI Ewer, Andrew/0000-0002-3825-4781; Cox, Phillip/0000-0002-4636-5668;
   Barrett, Timothy/0000-0002-6873-0750; Khan, Khalid
   Saeed/0000-0001-5084-7312; Thangaratinam, Shakila/0000-0002-4254-460X
CR Banerji MA, 1999, J CLIN ENDOCR METAB, V84, P137, DOI 10.1210/jc.84.1.137
   Barker D J, 1997, Rev Reprod, V2, P105, DOI 10.1530/revreprod/2.2.105
   Boney CM, 2005, PEDIATRICS, V115, pE290, DOI 10.1542/peds.2004-1808
   CHETCUTI P, 1985, ARCH DIS CHILD, V60, P868, DOI 10.1136/adc.60.9.868
   COOPER PJ, 1988, BRIT J PSYCHIAT, V152, P799, DOI 10.1192/bjp.152.6.799
   Cooper PJ, 1997, ARCH DIS CHILD, V77, P97, DOI 10.1136/adc.77.2.97
   Dennis CL, 2004, J AFFECT DISORDERS, V78, P163, DOI 10.1016/S0165-0327(02)00299-9
   DHAWAN J, 1994, BRIT HEART J, V72, P413
   ENAS EA, 1992, AM J CARDIOL, V70, P945, DOI 10.1016/0002-9149(92)90744-J
   ENAS EA, 1995, CLIN CARDIOL, V18, P131, DOI 10.1002/clc.4960180305
   GOTLIB IH, 1989, J CONSULT CLIN PSYCH, V57, P269, DOI 10.1037/0022-006X.57.2.269
   Griffiths R., 1976, The Abilities of Young Children
   HALES CN, 1992, DIABETOLOGIA, V35, P595, DOI 10.1093/ije/dyt133
   HALES CN, 1991, BMJ-BRIT MED J, V303, P1019, DOI 10.1136/bmj.303.6809.1019
   MCKEIGUE PM, 1991, LANCET, V337, P382, DOI 10.1016/0140-6736(91)91164-P
   Mukhopadhyay B, 2006, DIABETIC MED, V23, P94, DOI 10.1111/j.1464-5491.2005.01735.x
   MURRAY L, 1990, BRIT J PSYCHIAT, V157, P288, DOI 10.1192/bjp.157.2.288
   Neale MC., 2002, Mx: Statistical modeling, V6th
   NEEL JV, 1962, AM J HUM GENET, V14, P353
   O'Keeffe MJ, 2003, PEDIATRICS, V112, P301, DOI 10.1542/peds.112.2.301
   OHARA MW, 1984, J ABNORM PSYCHOL, V93, P158, DOI 10.1037/0021-843X.93.2.158
   Ong KKL, 2000, BRIT MED J, V320, P967, DOI 10.1136/bmj.320.7240.967
   Prentice AM, 2005, P NUTR SOC, V64, P153, DOI 10.1079/PNS2005421
   PRIMATESTA P, 2001, HLTH SURVEY ENGLAND
   RAMSAY M, 1977, EARLY HUM DEV, V1, P151, DOI 10.1016/0378-3782(77)90016-0
   Ray JG, 2001, QJM-INT J MED, V94, P347, DOI 10.1093/qjmed/94.7.347
   Tolsa CB, 2004, PEDIATR RES, V56, P132, DOI 10.1203/01.PDR.0000128983.54614.7E
   VALDEZ R, 1994, DIABETOLOGIA, V37, P624, DOI 10.1007/BF00403383
   Wallace JM, 2003, J PHYSIOL-LONDON, V547, P85, DOI 10.1113/jphysiol.2002.023333
   Westall C, 2011, MOTHERHOOD AND POSTNATAL DEPRESSION: NARRATIVES OF WOMEN AND THEIR PARTNERS, P7, DOI 10.1007/978-94-007-1694-0_2
   WILCOX M, 1993, BRIT MED J, V307, P588, DOI 10.1136/bmj.307.6904.588
   Wu GY, 2004, J NUTR, V134, P2169, DOI 10.1093/jn/134.9.2169
   Yajnik CS, 2002, J CLIN ENDOCR METAB, V87, P5575, DOI 10.1210/jc.2002-020434
   Yarbrough DE, 1998, DIABETES CARE, V21, P1652, DOI 10.2337/diacare.21.10.1652
NR 34
TC 1
Z9 1
U1 0
U2 10
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 1832-4274
EI 1839-2628
J9 TWIN RES HUM GENET
JI Twin Res. Hum. Genet.
PD DEC
PY 2006
VL 9
IS 6
BP 907
EP 912
PG 6
WC Genetics & Heredity; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Obstetrics & Gynecology
GA 122HO
UT WOS:000243216600036
PM 17254429
DA 2025-06-11
ER

PT J
AU Camp, OG
   Moussa, DN
   Hsu, R
   Awonuga, AO
   Abu-Soud, HM
AF Camp, Olivia G.
   Moussa, Daniel N.
   Hsu, Richard
   Awonuga, Awoniyi O.
   Abu-Soud, Husam M.
TI The interplay between oxidative stress, zinc, and metabolic dysfunction
   in polycystic ovarian syndrome
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Review
DE Polycystic Ovary Syndrome/PCOS; Oxidative stress; Zinc; Metabolic
   syndrome; Insulin resistance
ID TRACE-ELEMENT CONCENTRATIONS; INSULIN-RESISTANCE; SUPEROXIDE-DISMUTASE;
   SKELETAL-MUSCLE; DOUBLE-BLIND; WOMEN; SUPPLEMENTATION; MITOCHONDRIA;
   TRANSPORTERS; INFLAMMATION
AB Polycystic ovarian syndrome (PCOS) is a functional endocrine disorder characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology that has been associated with chronic disease and comorbidities including adverse metabolic and cardiac disorders. This review aims to evaluate the role of oxidative stress and zinc in the metabolic dysfunction observed in PCOS, with a focus on insulin resistance. Recent studies indicate that oxidative stress markers are elevated in PCOS and correlate with hyperandrogenemia, obesity, and insulin resistance. Zinc, an essential trace element, is crucial for metabolic processes, particularly in the pancreas for beta-cell function and glucagon secretion. Insufficient zinc levels have been linked to diabetes, obesity, and lipid metabolism disorders. This review aims to highlight the interplay between oxidative stress, zinc, and metabolic dysfunction in PCOS, suggesting that zinc supplementation could mitigate some metabolic and endocrine manifestations of PCOS.
C1 [Camp, Olivia G.; Moussa, Daniel N.; Hsu, Richard; Awonuga, Awoniyi O.; Abu-Soud, Husam M.] Wayne State Univ, Sch Med, CS Mott Ctr Human Growth & Dev, Dept Obstet & Gynecol, Detroit, MI 48201 USA.
   [Abu-Soud, Husam M.] Wayne State Univ, Sch Med, Dept Physiol, Detroit, MI 48201 USA.
   [Abu-Soud, Husam M.] Wayne State Univ, Sch Med, Dept Microbiol Immunol & Biochem, Detroit, MI 48201 USA.
C3 Wayne State University; Wayne State University; Wayne State University
RP Abu-Soud, HM (corresponding author), Wayne State Univ, Sch Med, CS Mott Ctr Human Growth & Dev, Dept Obstet & Gynecol, Detroit, MI 48201 USA.; Abu-Soud, HM (corresponding author), Wayne State Univ, Sch Med, Dept Physiol, Detroit, MI 48201 USA.; Abu-Soud, HM (corresponding author), Wayne State Univ, Sch Med, Dept Microbiol Immunol & Biochem, Detroit, MI 48201 USA.
EM habusoud@med.wayne.edu
OI Camp, Olivia/0000-0002-7015-4895
CR Abedini M, 2019, J TRACE ELEM MED BIO, V52, P216, DOI 10.1016/j.jtemb.2019.01.002
   Alesi S, 2022, ADV NUTR, V13, P1243, DOI 10.1093/advances/nmab141
   Andrés CMC, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24031841
   [Anonymous], 2016, DIETARY REFERENCE IN
   [Anonymous], 2001, COPYRIGHT 2001 NATL
   Awonuga AO, 2023, REPROD BIOL ENDOCRIN, V21, DOI 10.1186/s12958-023-01159-6
   Berbudi A, 2020, CURR DIABETES REV, V16, P442, DOI 10.2174/1573399815666191024085838
   Beyersmann D, 2001, BIOMETALS, V14, P331, DOI 10.1023/A:1012905406548
   Bhatti Jasvinder Singh, 2017, Biochim Biophys Acta Mol Basis Dis, V1863, P1066, DOI 10.1016/j.bbadis.2016.11.010
   Bizon A, 2022, J CLIN MED, V11, DOI 10.3390/jcm11092548
   Bizon A, 2020, GYNECOL ENDOCRINOL, V36, P951, DOI 10.1080/09513590.2020.1751111
   Bonaventura P, 2015, AUTOIMMUN REV, V14, P277, DOI 10.1016/j.autrev.2014.11.008
   Camp OG, 2023, REPROD SCI, V30, P2069, DOI 10.1007/s43032-023-01212-0
   Camp OG, 2022, NITRIC OXIDE-BIOL CH, V124, P32, DOI 10.1016/j.niox.2022.04.006
   Chimienti F, 2004, DIABETES, V53, P2330, DOI 10.2337/diabetes.53.9.2330
   CIARALDI TP, 1992, J CLIN ENDOCR METAB, V75, P577, DOI 10.1210/jc.75.2.577
   Cruz KJC, 2015, WORLD J DIABETES, V6, P333, DOI 10.4239/wjd.v6.i2.333
   Colvin RA, 2010, METALLOMICS, V2, P306, DOI 10.1039/b926662c
   Lima VBD, 2011, ARQ BRAS ENDOCRINOL, V55, P701, DOI 10.1590/S0004-27302011000900006
   Dhar S, 2024, J HUM REPROD SCI, V17, P25, DOI 10.4103/jhrs.jhrs_8_24
   Dufner-Beattie J, 2004, J BIOL CHEM, V279, P49082, DOI 10.1074/jbc.M409962200
   Dumesic DA, 2013, STEROIDS, V78, P782, DOI 10.1016/j.steroids.2013.04.004
   Ebrahimi FA, 2018, BIOL TRACE ELEM RES, V184, P300, DOI 10.1007/s12011-017-1198-5
   Eide DJ, 2011, METALLOMICS, V3, P1124, DOI 10.1039/c1mt00064k
   ElObeid T, 2022, METABOLITES, V12, DOI 10.3390/metabo12040338
   Foroozanfard F, 2015, EXP CLIN ENDOCR DIAB, V123, P215, DOI 10.1055/s-0035-1548790
   Foster M, 2012, NUTRIENTS, V4, P676, DOI 10.3390/nu4070676
   Garvey WT, 1998, J CLIN INVEST, V101, P2377, DOI 10.1172/JCI1557
   Gilbert EW, 2018, CLIN ENDOCRINOL, V89, P683, DOI 10.1111/cen.13828
   González F, 2012, AM J PHYSIOL-ENDOC M, V302, pE297, DOI 10.1152/ajpendo.00416.2011
   Grbz A., 2021, ARCH MED RES, V1, P12, DOI [10.47482/acmr.2020.2, DOI 10.47482/ACMR.2020.2]
   Guler I, 2014, BIOL TRACE ELEM RES, V158, P297, DOI 10.1007/s12011-014-9941-7
   Günalan E, 2018, J TURK-GER GYNECOL A, V19, P220, DOI 10.4274/jtgga.2018.0077
   Hennigar SR, 2018, J NUTR, V148, P1341, DOI 10.1093/jn/nxy105
   Hu F, 2011, CELL SIGNAL, V23, P1528, DOI 10.1016/j.cellsig.2011.05.008
   Hussain A, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.717064
   Jaeschke H, 2010, COMPREHENSIVE TOXICOLOGY, VOL 9: HEPATIC TOXICOLOGY, 2ND EDITION, P319
   Jamilian M, 2016, BIOL TRACE ELEM RES, V170, P271, DOI 10.1007/s12011-015-0480-7
   Jana W, 2022, ZINC, P963, DOI [10.1016/B978-0-12-822946-0.00034-9, DOI 10.1016/B978-0-12-822946-0.00034-9]
   Janati S, 2021, INT J FERTIL STERIL, V15, P197, DOI 10.22074/IJFS.2021.135426.1006
   Kamikihara T, 2005, INT J CANCER, V115, P690, DOI 10.1002/ijc.20971
   Kelleher SL, 2011, ADV NUTR, V2, P101, DOI 10.3945/an.110.000232
   KELLER SR, 1995, J BIOL CHEM, V270, P23612, DOI 10.1074/jbc.270.40.23612
   Kelley DE, 2002, DIABETES, V51, P2944, DOI 10.2337/diabetes.51.10.2944
   Kim KW, 2021, J OBES METAB SYNDR, V30, P209
   Komosinska-Vassev K, 2005, DIABETES RES CLIN PR, V68, P207, DOI 10.1016/j.diabres.2004.10.004
   Kowalczyk P, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222413384
   Krezel A, 2016, ARCH BIOCHEM BIOPHYS, V611, P3, DOI 10.1016/j.abb.2016.04.010
   Li XK, 2007, MINI-REV MED CHEM, V7, P761
   Maret W, 2007, MOL MED, V13, P371, DOI 10.2119/2007-00036.Maret
   Maret Wolfgang, 2017, Prev Nutr Food Sci, V22, P1
   Marreiro DD, 2017, ANTIOXIDANTS-BASEL, V6, DOI 10.3390/antiox6020024
   Mason AZ, 2004, MAR ENVIRON RES, V58, P371, DOI 10.1016/j.marenvres.2004.03.082
   Mayor-Ibarguren A, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.01736
   Maywald M, 2022, BIOMOLECULES, V12, DOI 10.3390/biom12121748
   Mezzetti A, 1998, FREE RADICAL BIO MED, V25, P676, DOI 10.1016/S0891-5849(98)00109-9
   Nasiadek M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12082464
   Nasiri N, 2015, EUR J OBSTET GYN R B, V184, P112, DOI 10.1016/j.ejogrb.2014.11.008
   Olechnowicz J, 2018, J PHYSIOL SCI, V68, P19, DOI 10.1007/s12576-017-0571-7
   Ott M, 2007, APOPTOSIS, V12, P913, DOI 10.1007/s10495-007-0756-2
   Özcelik D, 2012, BIOL TRACE ELEM RES, V150, P342, DOI 10.1007/s12011-012-9508-4
   Plum LM, 2010, INT J ENV RES PUB HE, V7, P1342, DOI 10.3390/ijerph7041342
   Rajni D., 2020, INT J CLIN OBSTET, V4, P88, DOI [10.33545/gynae.2020.v4.i1b.446, DOI 10.33545/GYNAE.2020.V4.I1B.446]
   Savic-Radojevic A, 2015, HORM-INT J ENDOCRINO, V14, P101, DOI 10.14310/horm.2002.1525
   SCHULZEOSTHOFF K, 1992, J BIOL CHEM, V267, P5317
   Seleem AK, 2014, J ASSIST REPROD GEN, V31, P499, DOI 10.1007/s10815-014-0190-7
   Sharma P, 2022, BIOL TRACE ELEM RES, V200, P4582, DOI 10.1007/s12011-021-03058-6
   Spritzer PM, 2017, BIOL TRACE ELEM RES, V175, P254, DOI 10.1007/s12011-016-0774-4
   Stepto NK, 2013, HUM REPROD, V28, P777, DOI 10.1093/humrep/des463
   VALLEE BL, 1993, PHYSIOL REV, V73, P79, DOI 10.2466/pr0.1993.73.1.79
   Wittmann I, 1996, DIABETOLOGIA, V39, P1002
   Yin JC, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.572384
   Yokokawa H, 2020, J GEN FAM MED, V21, P248, DOI 10.1002/jgf2.377
   Zhang JS, 2019, REPROD BIOL ENDOCRIN, V17, DOI 10.1186/s12958-019-0509-4
   Zhang Y, 2017, ONCOTARGET, V8, P80472, DOI 10.18632/oncotarget.19058
   Zheng GC, 2015, BIOL TRACE ELEM RES, V167, P1, DOI 10.1007/s12011-015-0294-7
   Zuo T, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/8589318
NR 77
TC 1
Z9 1
U1 2
U2 4
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD APR
PY 2025
VL 480
IS 4
BP 2015
EP 2023
DI 10.1007/s11010-024-05113-x
EA SEP 2024
PG 9
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 0VY8Z
UT WOS:001310620200001
PM 39266804
DA 2025-06-11
ER

PT J
AU Alexandru, N
   Popov, D
   Georgescu, A
AF Alexandru, Nicoleta
   Popov, Doina
   Georgescu, Adriana
TI Intraplatelet Oxidative/Nitrative Stress: Inductors, Consequences, and
   Control
SO TRENDS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
AB This article provides an overview of the current knowledge on intraplatelet oxidative/nitrative stress, an abnormality associated with platelet activation and hyper-reactivity. The first issue discussed is related to induction of platelet endogenous stress by the molecules present within the circulating (extracellular) milieu that bathes these cells. The second issue concerns the intra platelet oxidative/nitrative stress associated with specific pathologies or clinical procedures and action of particular molecules and platelet agonists as well as of the specialized intraplatelet milieu and its redox system; the biomarkers of endogenous oxidative/nitrative stress are also briefly outlined. Next, the association between intraplatelet oxidative/nitrative stress and the risk factors of the metabolic syndrome is presented. Then, the most recent strategies aimed at the control/regulation of platelet endogenous oxidative/nitrative stress, such as exploitation of circulating extracellular reactive oxygen species scavengers, manipulation of platelet molecules, and the use of antioxidants, are discussed. Finally, the results of studies on platelet-dependent redox mechanisms, which deserve immediate attention for potential clinical exploitation, are illustrated. (Trends Cardiovasc Med 2010;20:232-238) (C) 2010 Elsevier Inc. All rights reserved.
C1 [Alexandru, Nicoleta; Georgescu, Adriana] Romanian Acad, Inst Cellular Biol & Pathol Nicolae Simionescu, Dept Cellular Physiol & Pharmacol, Bucharest 050568, Romania.
   [Alexandru, Nicoleta; Georgescu, Adriana] Petru Poni Inst Macromol Chem, Iasi 700487, Romania.
C3 Romanian Academy; Nicolae Simionescu Institute of Cellular Biology &
   Pathology; Romanian Academy; Petru Poni Institute of Macromolecular
   Chemistry
RP Alexandru, N (corresponding author), Romanian Acad, Inst Cellular Biol & Pathol Nicolae Simionescu, Dept Cellular Physiol & Pharmacol, 8,BP Hasdeu St,POB 35-14, Bucharest 050568, Romania.
EM nicoleta.alexandru@icbp.ro; adriana.georgescu@icbp.ro
RI L, Popov/AAY-5640-2020; Georgescu, Adriana/B-9185-2011; Alexandru-Moise,
   Nicoleta/E-5689-2011
OI Georgescu, Adriana/0000-0003-4945-1745
FU Romanian Ministry of Education, Research Youth and Sport; National
   Program for Research-Development and Innovation; National Authority for
   Scientific Research [1159/19.01.2009, 1043/2008]; National Centre for
   Programs' Management (CNMP) [42138/1.10.2008, 3334/2008]; European
   Social Fund [ID POSDRU/89/1.5/S/55216]; Romanian Academy
FX The authors' research is supported by grants from the Romanian Ministry
   of Education, Research Youth and Sport, including National Program for
   Research-Development and Innovation 2 (PNCDI-2); The National Authority
   for Scientific Research, Idea Program 1-Funding Application for
   Exploratory Research Projects (grant 1159/19.01.2009, PNII-IDEI code
   1043/2008); PNCDI-2, National Centre for Programs' Management (CNMP),
   Partnerships Program 4, Direction 4-Health (grant 42138/1.10.2008, code
   3334/2008); the European Social Fund-"Cristofor I. Simionescu"
   Postdoctoral Fellowship Program (ID POSDRU/89/1.5/S/55216); Sectoral
   Operational Program Human Resources Development 2007-2013; and by the
   Romanian Academy.
CR Abou-Saleh H, 2009, CIRCULATION, V120, P2230, DOI 10.1161/CIRCULATIONAHA.109.894642
   Alexandru N, 2011, J THROMB HAEMOST, V9, P173, DOI 10.1111/j.1538-7836.2010.04122.x
   Arthur JF, 2008, PLATELETS, V19, P1, DOI 10.1080/09537100701817224
   Assinger A, 2010, ATHEROSCLEROSIS, V213, P129, DOI 10.1016/j.atherosclerosis.2010.07.018
   Assinger A, 2010, ATHEROSCLEROSIS, V212, P153, DOI 10.1016/j.atherosclerosis.2010.05.010
   Bakdash N, 2008, FREE RADICAL BIO MED, V45, P158, DOI 10.1016/j.freeradbiomed.2008.03.021
   Begonja AJ, 2006, BLOOD CELL MOL DIS, V36, P166, DOI 10.1016/j.bcmd.2005.12.028
   Bermejo E, 2005, THROMB HAEMOSTASIS, V94, P578, DOI 10.1160/TH05-01-0062
   Bouaziz A, 2007, ARCH BIOCHEM BIOPHYS, V457, P235, DOI 10.1016/j.abb.2006.10.020
   Brill A, 2009, CARDIOVASC RES, V84, P137, DOI 10.1093/cvr/cvp176
   Chakrabarti S, 2005, ARTERIOSCL THROM VAS, V25, P2428, DOI 10.1161/01.ATV.0000184765.59207.f3
   Chakrabarti S, 2010, CARDIOVASC THER, V28, P227, DOI 10.1111/j.1755-5922.2010.00161.x
   Colas R, 2011, DIABETOLOGIA, V54, P2931, DOI 10.1007/s00125-011-2272-8
   Siqueira MAD, 2011, CAN J PHYSIOL PHARM, V89, P97, DOI [10.1139/Y10-111, 10.1139/y10-111]
   Del Principe D, 2009, THROMB HAEMOSTASIS, V101, P284, DOI 10.1160/TH08-05-0300
   Dionisio N, 2010, CURR MED CHEM, V17, P3109, DOI 10.2174/092986710791959783
   Dong HP, 2010, KAOHSIUNG J MED SCI, V26, P584, DOI 10.1016/S1607-551X(10)70090-5
   El Haouari M, 2011, MINI-REV MED CHEM, V11, P131, DOI 10.2174/138955711794519537
   El Haouari M, 2008, BLOOD CELL MOL DIS, V41, P119, DOI 10.1016/j.bcmd.2008.02.010
   Essex DW, 2009, ANTIOXID REDOX SIGN, V11, P1191, DOI [10.1089/ars.2008.2322, 10.1089/ARS.2008.2322]
   Formoso G, 2008, DIABETES-METAB RES, V24, P231, DOI 10.1002/dmrr.794
   Freedman JE, 2008, ARTERIOSCL THROM VAS, V28, pS11, DOI 10.1161/ATVBAHA.107.159178
   Garelnabi M, 2010, J CLIN LAB ANAL, V24, P49, DOI 10.1002/jcla.20363
   Han JY, 2011, J PHARMACOL EXP THER, V338, P82, DOI 10.1124/jpet.111.180620
   Helal O, 2011, NUTR METAB CARDIOVAS, V21, P665, DOI 10.1016/j.numecd.2010.01.004
   Hoffman MD, 2009, MOL CELL PROTEOMICS, V8, P887, DOI 10.1074/mcp.M800230-MCP200
   IJsselmuiden AJJ, 2008, NAT CLIN PRACT CARD, V5, P811, DOI 10.1038/ncpcardio1364
   Jennings LK, 2009, THROMB HAEMOSTASIS, V102, P248, DOI 10.1160/TH09-03-0192
   Jin RC, 2011, CIRCULATION, V123, P1963, DOI 10.1161/CIRCULATIONAHA.110.000034
   Kedzierska M, 2010, PLATELETS, V21, P541, DOI 10.3109/09537104.2010.492534
   Kolodziejczyk J, 2011, J PHYSIOL BIOCHEM, V67, P391, DOI 10.1007/s13105-011-0089-z
   Kolodziejczyk J, 2011, PLATELETS, V22, P270, DOI 10.3109/09537104.2010.547637
   Kolodziejczyk J, 2009, PLATELETS, V20, P487, DOI 10.3109/09537100903165182
   Linden MD, 2010, INT J BIOCHEM CELL B, V42, P1762, DOI 10.1016/j.biocel.2010.07.012
   Lopez JJ, 2007, J THROMB HAEMOST, V5, P1283, DOI 10.1111/j.1538-7836.2007.02505.x
   López JJ, 2008, LIFE SCI, V82, P977, DOI 10.1016/j.lfs.2008.03.009
   McCarty MF, 2007, MED HYPOTHESES, V69, P12, DOI 10.1016/j.mehy.2004.08.035
   Moss MB, 2010, CLIN EXP PHARMACOL P, V37, P167, DOI 10.1111/j.1440-1681.2009.05247.x
   Nofer JR, 2010, CLIN EXP PHARMACOL P, V37, P726, DOI 10.1111/j.1440-1681.2010.05377.x
   Nowak Pawel, 2010, Postepy Biochem, V56, P239
   O'Kane P, 2009, CARDIOVASC RES, V83, P123, DOI 10.1093/cvr/cvp120
   Olas B, 2008, J PHYSIOL PHARMACOL, V59, P823
   Olas B, 2008, CELL BIOL TOXICOL, V24, P331, DOI 10.1007/s10565-007-9045-7
   Olas B, 2007, PLATELETS, V18, P555, DOI 10.1080/09537100701504087
   Olas B, 2011, PLATELETS, V22, P345, DOI 10.3109/09537104.2010.549597
   Olas B, 2010, PLATELETS, V21, P274, DOI 10.3109/09537101003612821
   Pereira NR, 2010, BLOOD CELL MOL DIS, V44, P164, DOI 10.1016/j.bcmd.2009.12.003
   Rubenstein DA, 2009, PLATELETS, V20, P206, DOI 10.1080/09537100902795492
   Rukoyatkina N, 2011, THROMB HAEMOST, V106
   Saluk-Juszczak J, 2010, INT J BIOL MACROMOL, V47, P700, DOI 10.1016/j.ijbiomac.2010.09.007
   Saluk-Juszczak J, 2010, PLATELETS, V21, P451, DOI 10.3109/09537101003780032
   Saluk-Juszczak J, 2010, CELL BIOL TOXICOL, V26, P355, DOI 10.1007/s10565-009-9148-4
   Sauk-Juszczak J, 2008, NUTR METAB CARDIOVAS, V18, P422, DOI 10.1016/j.numecd.2007.02.016
   Schubert P, 2010, J PROTEOMICS, V73, P436, DOI 10.1016/j.jprot.2009.08.002
   Sener A, 2009, FOLIA BIOL-PRAGUE, V55, P45
   Shah A, 2011, CARDIOVASC RES, V91, P625, DOI 10.1093/cvr/cvr115
   Shantsila E, 2010, J THROMB HAEMOST, V8, P2358, DOI 10.1111/j.1538-7836.2010.04007.x
   Silverstein RL, 2009, CLIN LIPIDOL, V4, P767, DOI 10.2217/CLP.09.57
   Stokes KY, 2007, FREE RADICAL BIO MED, V43, P22, DOI 10.1016/j.freeradbiomed.2007.02.027
   Wang WQ, 2011, PHYSIOL RES, V60, P347, DOI 10.33549/physiolres.932044
   Yamagishi SI, 2009, DIABETES-METAB RES, V25, P266, DOI 10.1002/dmrr.906
   Zhao Xiao-Min, 2011, Sheng Li Ke Xue Jin Zhan, V42, P33
NR 62
TC 9
Z9 9
U1 1
U2 4
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1050-1738
J9 TRENDS CARDIOVAS MED
JI Trends Cardiovasc. Med.
PD OCT
PY 2010
VL 20
IS 7
BP 232
EP 238
AR PII S1050-1738(11)00086-7
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA V21PR
UT WOS:000208220000005
PM 22293024
DA 2025-06-11
ER

PT J
AU Keane, KN
   Cruzat, VF
   Carlessi, R
   de Bittencourt, PIH
   Newsholme, P
AF Keane, Kevin Noel
   Cruzat, Vinicius Fernandes
   Carlessi, Rodrigo
   Homem de Bittencourt, Paulo Ivo, Jr.
   Newsholme, Philip
TI Molecular Events Linking Oxidative Stress and Inflammation to Insulin
   Resistance and β-Cell Dysfunction
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID ENDOPLASMIC-RETICULUM STRESS; NF-KAPPA-B; SUPEROXIDE-DISMUTASE
   EXPRESSION; ISLET-ASSOCIATED MACROPHAGES; UNFOLDED PROTEIN RESPONSE;
   CULTURED RAT ADIPOCYTES; LOW-DENSITY-LIPOPROTEIN; REACTIVE OXYGEN; ER
   STRESS; NUTRIENT REGULATION
AB The prevalence of diabetes mellitus (DM) is increasing worldwide, a consequence of the alarming rise in obesity and metabolic syndrome (MetS). Oxidative stress and inflammation are key physiological and pathological events linking obesity, insulin resistance, and the progression of type 2 DM (T2DM). Unresolved inflammation alongside a "glucolipotoxic" environment of the pancreatic islets, in insulin resistant pathologies, enhances the infiltration of immune cells which through secretory activity cause dysfunction of insulin-secreting beta-cells and ultimately cell death. Recent molecular investigations have revealed that mechanisms responsible for insulin resistance associated with T2DM are detected in conditions such as obesity and MetS, including impaired insulin receptor (IR) signalling in insulin responsive tissues, oxidative stress, and endoplasmic reticulum (ER) stress. The aim of the present review is to describe the evidence linking oxidative stress and inflammation with impairment of insulin secretion and action, which result in the progression of T2DM and other conditions associated with metabolic dysregulation.
C1 [Keane, Kevin Noel; Cruzat, Vinicius Fernandes; Carlessi, Rodrigo; Newsholme, Philip] Curtin Univ, Sch Biomed Sci, Curtin Hlth Innovat Res Inst, Biosci, Perth, WA 6102, Australia.
   [Cruzat, Vinicius Fernandes] Univ Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, Sao Paulo, SP, Brazil.
   [Carlessi, Rodrigo] Univ Fed Rio Grande do Sul, Postgrad Program Med Sci Endocrinol, BR-90035003 Porto Alegre, RS, Brazil.
   [Homem de Bittencourt, Paulo Ivo, Jr.] Univ Fed Rio Grande do Sul, Inst Basic Hlth Sci, Dept Physiol, BR-90050170 Porto Alegre, RS, Brazil.
C3 Curtin University; Universidade de Sao Paulo; Institute Biomed Science,
   University Sao Paulo; Universidade Federal do Rio Grande do Sul;
   Universidade Federal do Rio Grande do Sul
RP Cruzat, VF (corresponding author), Curtin Univ, Sch Biomed Sci, Curtin Hlth Innovat Res Inst, Biosci, Perth, WA 6102, Australia.
EM vinifc@usp.br
RI Cruzat, Vinicius/HOF-1622-2023; Carlessi, Rodrigo/JCE-0678-2023; Homem
   de Bittencourt Jr., Paulo Ivo/D-1156-2011; Newsholme,
   Philip/D-4939-2016; Cruzat, Vinicius/I-6920-2013; Keane, Kevin
   N./M-3149-2017
OI Homem de Bittencourt Jr., Paulo Ivo/0000-0003-1907-3341; Carlessi,
   Rodrigo/0000-0003-0038-7391; Newsholme, Philip/0000-0002-0500-6984;
   Cruzat, Vinicius/0000-0001-9879-4985; Keane, Kevin
   N./0000-0001-6248-7705
FU Brazilian National Council for Scientific and Technological Development
   (CNPq) [402626/2012-5, 245562/2012-5, 150454/2015-5, 200164/2014-7]
FX The authors thank Curtin University School of Biomedical Sciences for
   research support. This work was partially supported by grants from the
   Brazilian National Council for Scientific and Technological Development
   (CNPq) Science without Borders Programme: Special Visiting Scientist
   Fellowship to Philip Newsholme (no. 402626/2012-5), Postdoctoral
   Fellowship to Vinicius Fernandes Cruzat (nos. 245562/2012-5 and
   150454/2015-5), and Ph.D. Scholarship to Rodrigo Carlessi (no.
   200164/2014-7).
CR Allagnat F, 2012, CELL DEATH DIFFER, V19, P1836, DOI 10.1038/cdd.2012.67
   Allagnat F, 2011, CELL DEATH DIFFER, V18, P328, DOI 10.1038/cdd.2010.105
   ARAKI E, 1994, NATURE, V372, P186, DOI 10.1038/372186a0
   Archuleta TL, 2009, FREE RADICAL BIO MED, V47, P1486, DOI 10.1016/j.freeradbiomed.2009.08.014
   Arikoglu H, 2014, META GENE, V2, P579, DOI 10.1016/j.mgene.2014.07.008
   Barbour LA, 2004, ENDOCRINOLOGY, V145, P1144, DOI 10.1210/en.2003-1297
   Boslem E, 2011, BIOCHEM J, V435, P267, DOI 10.1042/BJ20101867
   Burén J, 2003, EUR J ENDOCRINOL, V148, P157, DOI 10.1530/eje.0.1480157
   Butterfield DA, 2014, BBA-MOL BASIS DIS, V1842, P1693, DOI 10.1016/j.bbadis.2014.06.010
   Cardozo AK, 2005, DIABETES, V54, P452, DOI 10.2337/diabetes.54.2.452
   Catena C, 2003, KIDNEY INT, V64, P2163, DOI 10.1046/j.1523-1755.2003.00313.x
   Cho H, 2001, SCIENCE, V292, P1728, DOI 10.1126/science.292.5522.1728
   Contreras C, 2014, CELL REP, V9, P366, DOI 10.1016/j.celrep.2014.08.057
   Corcoran MP, 2007, AM J CLIN NUTR, V85, P662
   Corless M, 2006, J ENDOCRINOL, V190, P719, DOI 10.1677/joe.1.06892
   Crow J P, 1995, Curr Top Microbiol Immunol, V196, P57
   Cruzat VF, 2014, J NUTR BIOCHEM, V25, P345, DOI 10.1016/j.jnutbio.2013.11.009
   Cruzat VF, 2009, NUTRITION, V25, P428, DOI 10.1016/j.nut.2008.09.014
   Cruzat VF, 2015, J ENDOCRINOL, V224, P261, DOI 10.1530/JOE-14-0677
   Cruzat VF, 2014, NUTRITION, V30, P602, DOI 10.1016/j.nut.2013.10.019
   Cruzat VF, 2010, CELL BIOCHEM FUNCT, V28, P24, DOI 10.1002/cbf.1611
   Darville MI, 2000, ENDOCRINOLOGY, V141, P153, DOI 10.1210/en.141.1.153
   Delaney CA, 1996, FEBS LETT, V394, P300, DOI 10.1016/0014-5793(96)00977-5
   Di Naso F, 2015, OBESITY, V23, P120, DOI 10.1002/oby.20919
   Dominiczak MH, 2011, ANN CLIN BIOCHEM, V48, P498, DOI 10.1258/acb.2011.011111
   Donath MY, 2008, DIABETES CARE, V31, pS161, DOI 10.2337/dc08-s243
   Eguchi K, 2012, CELL METAB, V15, P518, DOI 10.1016/j.cmet.2012.01.023
   Ehses JA, 2008, BIOCHEM SOC T, V36, P340, DOI 10.1042/BST0360340
   Ehses JA, 2007, DIABETES, V56, P2356, DOI 10.2337/db06-1650
   Eizirik DL, 2013, DIABETOLOGIA, V56, P234, DOI 10.1007/s00125-012-2762-3
   Eizirik DL, 2008, ENDOCR REV, V29, P42, DOI 10.1210/er.2007-0015
   Eizirik DL, 2001, DIABETOLOGIA, V44, P2115, DOI 10.1007/s001250100021
   Elosua R, 2003, OBES RES, V11, P1502, DOI 10.1038/oby.2003.201
   Elouil H, 2007, DIABETOLOGIA, V50, P1442, DOI 10.1007/s00125-007-0674-4
   Elouil H, 2005, DIABETOLOGIA, V48, P496, DOI 10.1007/s00125-004-1664-4
   Fonseca SG, 2011, TRENDS ENDOCRIN MET, V22, P266, DOI 10.1016/j.tem.2011.02.008
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Foti D, 2005, NAT MED, V11, P765, DOI 10.1038/nm1254
   Gao D, 2010, J BIOL CHEM, V285, P29965, DOI 10.1074/jbc.M110.128694
   Gao JH, 2007, DIABETES, V56, P24, DOI 10.2337/db06-0144
   GARVEY WT, 1986, DIABETES, V35, P258, DOI 10.2337/diabetes.35.3.258
   Gehrmann W, 2010, DIABETES OBES METAB, V12, P149, DOI 10.1111/j.1463-1326.2010.01265.x
   Gray JP, 2010, TOXICOL MECH METHOD, V20, P167, DOI 10.3109/15376511003695181
   Gurzov EN, 2009, CELL DEATH DIFFER, V16, P1539, DOI 10.1038/cdd.2009.99
   Gurzov EN, 2011, TRENDS CELL BIOL, V21, P424, DOI 10.1016/j.tcb.2011.03.001
   Gurzov EN, 2010, J BIOL CHEM, V285, P19910, DOI 10.1074/jbc.M110.122374
   Gwiazda KS, 2009, AM J PHYSIOL-ENDOC M, V296, pE690, DOI 10.1152/ajpendo.90525.2008
   Hamiel CR, 2009, AM J PHYSIOL-CELL PH, V297, pC1509, DOI 10.1152/ajpcell.00240.2009
   Harding HP, 2000, MOL CELL, V5, P897, DOI 10.1016/S1097-2765(00)80330-5
   Heimberg H, 2001, DIABETES, V50, P2219, DOI 10.2337/diabetes.50.10.2219
   Henriksen EJ, 2011, FREE RADICAL BIO MED, V51, P993, DOI 10.1016/j.freeradbiomed.2010.12.005
   Hotamisligil GS, 1996, SCIENCE, V271, P665, DOI 10.1126/science.271.5249.665
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Huri HZ, 2012, INT J CLIN PHARM-NET, V34, P863, DOI 10.1007/s11096-012-9682-7
   Inoshita S, 2002, J BIOL CHEM, V277, P43730, DOI 10.1074/jbc.M207951200
   Iwahashi H, 1996, DIABETOLOGIA, V39, P530, DOI 10.1007/s001250050475
   Jackson RJ, 2010, NAT REV MOL CELL BIO, V11, P113, DOI 10.1038/nrm2838
   Jacobson J, 2004, MOL CELL BIOCHEM, V256, P209, DOI 10.1023/B:MCBI.0000009869.29827.df
   Jeffrey KD, 2008, P NATL ACAD SCI USA, V105, P8452, DOI 10.1073/pnas.0711232105
   Jourdan T, 2013, NAT MED, V19, P1132, DOI 10.1038/nm.3265
   Kahn SE, 2006, NATURE, V444, P840, DOI 10.1038/nature05482
   Kajimoto Y, 2004, ANN NY ACAD SCI, V1011, P168, DOI 10.1196/annals.1293.017
   Karin M, 1999, ONCOGENE, V18, P6867, DOI 10.1038/sj.onc.1203219
   Kim H, 2006, NAT CELL BIOL, V8, P1348, DOI 10.1038/ncb1499
   KODAMA H, 1994, DIABETOLOGIA, V37, P739, DOI 10.1007/s001250050173
   Kolb H, 2010, DIABETOLOGIA, V53, P10, DOI 10.1007/s00125-009-1573-7
   Krause M, 2014, CLIN SCI, V126, P739, DOI 10.1042/CS20130678
   Krause M, 2012, METABOLISM, V61, P1528, DOI 10.1016/j.metabol.2012.05.003
   Krause MS, 2011, J ENDOCRINOL, V211, P87, DOI 10.1530/JOE-11-0236
   Kubota N, 2000, DIABETES, V49, P1880, DOI 10.2337/diabetes.49.11.1880
   Laybutt DR, 2007, DIABETOLOGIA, V50, P752, DOI 10.1007/s00125-006-0590-z
   Lee E, 2011, BIOCHEM BIOPH RES CO, V414, P397, DOI 10.1016/j.bbrc.2011.09.087
   Leloup C, 2009, DIABETES, V58, P673, DOI 10.2337/db07-1056
   Lenzen S, 2008, BIOCHEM SOC T, V36, P343, DOI 10.1042/BST0360343
   Li SS, 2009, JAMA-J AM MED ASSOC, V302, P179, DOI 10.1001/jama.2009.976
   Lipson KL, 2006, CELL METAB, V4, P245, DOI 10.1016/j.cmet.2006.07.007
   Lortz S, 2005, DIABETOLOGIA, V48, P1541, DOI 10.1007/s00125-005-1822-3
   Maedler K, 2002, J CLIN INVEST, V110, P851, DOI 10.1172/JCI200215318
   Mahadevan J, 2013, DIABETES, V62, P3582, DOI 10.2337/db13-0357
   MandrupPoulsen T, 1996, DIABETOLOGIA, V39, P1005, DOI 10.1007/BF00400649
   Manning BD, 2007, CELL, V129, P1261, DOI 10.1016/j.cell.2007.06.009
   Marques-Vidal P, 2003, OBES RES, V11, P1200, DOI 10.1038/oby.2003.165
   Martínez-Gómez LE, 2011, ANN HUM GENET, V75, P612, DOI 10.1111/j.1469-1809.2011.00668.x
   Masters SL, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3001902
   Masters SL, 2010, NAT IMMUNOL, V11, P897, DOI 10.1038/ni.1935
   McCullough KD, 2001, MOL CELL BIOL, V21, P1249, DOI 10.1128/MCB.21.4.1249-1259.2001
   Medzhitov R, 2010, CELL, V140, P771, DOI 10.1016/j.cell.2010.03.006
   Menge BA, 2010, REGUL PEPTIDES, V160, P75, DOI 10.1016/j.regpep.2009.08.001
   Merrick WC, 2004, GENE, V332, P1, DOI 10.1016/j.gene.2004.02.051
   Nathan C, 2010, CELL, V140, P871, DOI 10.1016/j.cell.2010.02.029
   Newsholme P, 2007, J PHYSIOL-LONDON, V583, P9, DOI 10.1113/jphysiol.2007.135871
   Newsholme P, 2012, J ENDOCRINOL, V214, P11, DOI 10.1530/JOE-12-0072
   Newsholme P, 2003, CELL BIOCHEM FUNCT, V21, P1, DOI 10.1002/cbf.1003
   Newsholme P., 2014, Systems Biology of Free Radicals and Antioxidants, P3361, DOI [10.1007/978-3-642-30018-9, DOI 10.1007/978-3-642-30018-9, DOI 10.1007/978-3-642-30018-9_152]
   Newsholme P, 2014, J ENDOCRINOL, V221, pR105, DOI 10.1530/JOE-13-0616
   Newsholme P, 2014, CURR OPIN CLIN NUTR, V17, P295, DOI 10.1097/MCO.0000000000000077
   Newsholme P, 2010, ADV EXP MED BIOL, V654, P91, DOI 10.1007/978-90-481-3271-3_6
   Oslowski CM, 2012, CELL METAB, V16, P265, DOI 10.1016/j.cmet.2012.07.005
   Oyadomari S, 2001, P NATL ACAD SCI USA, V98, P10845, DOI 10.1073/pnas.191207498
   Poitout V, 2008, ENDOCR REV, V29, P351, DOI 10.1210/er.2007-0023
   Potashnik R, 2003, DIABETOLOGIA, V46, P639, DOI 10.1007/s00125-003-1097-5
   Pratt WB, 2010, EXP BIOL MED, V235, P278, DOI 10.1258/ebm.2009.009250
   Preston AM, 2009, DIABETOLOGIA, V52, P2369, DOI 10.1007/s00125-009-1506-5
   Quan W, 2013, DIABETES OBES METAB, V15, P141, DOI 10.1111/dom.12153
   RABINOVITCH A, 1994, DIABETOLOGIA, V37, P733, DOI 10.1007/s001250050172
   Rabinovitch A, 2003, REV ENDOCR METAB DIS, V4, P291, DOI 10.1023/A:1025160614313
   Rao RV, 2004, CURR OPIN CELL BIOL, V16, P653, DOI 10.1016/j.ceb.2004.09.012
   Richardson SJ, 2009, DIABETOLOGIA, V52, P1143, DOI 10.1007/s00125-009-1276-0
   Rizzo MA, 2003, J CELL BIOL, V161, P243, DOI 10.1083/jcb.200301063
   ROSS R, 1973, SCIENCE, V180, P1332, DOI 10.1126/science.180.4093.1332
   Ruiz-Núñez B, 2013, J NUTR BIOCHEM, V24, P1183, DOI 10.1016/j.jnutbio.2013.02.009
   Saini V, 2010, WORLD J DIABETES, V1, P68, DOI 10.4239/wjd.v1.i3.68
   Sarkar SA, 2009, DIABETOLOGIA, V52, P1092, DOI 10.1007/s00125-009-1331-x
   Scheuner D, 2005, NAT MED, V11, P757, DOI 10.1038/nm1259
   Schoonbroodt S, 2000, BIOCHEM PHARMACOL, V60, P1075, DOI 10.1016/S0006-2952(00)00371-3
   SHULMAN GI, 1990, NEW ENGL J MED, V322, P223, DOI 10.1056/NEJM199001253220403
   Storling J, 2005, DIABETOLOGIA, V48, P2039, DOI 10.1007/s00125-005-1912-2
   Stuart CA, 2014, PHYSIOL REP, V2, DOI 10.14814/phy2.12236
   Symons JD, 2013, REV ENDOCR METAB DIS, V14, P59, DOI 10.1007/s11154-012-9235-3
   Szegezdi E, 2006, EMBO REP, V7, P880, DOI 10.1038/sj.embor.7400779
   Talbot K, 2012, J CLIN INVEST, V122, P1316, DOI 10.1172/JCI59903
   Tanaka Y, 2002, P NATL ACAD SCI USA, V99, P12363, DOI 10.1073/pnas.192445199
   Taniguchi CM, 2006, NAT REV MOL CELL BIO, V7, P85, DOI 10.1038/nrm1837
   Taniguchi CM, 2006, P NATL ACAD SCI USA, V103, P12093, DOI 10.1073/pnas.0604628103
   Tateya Sanshiro, 2013, Front Endocrinol (Lausanne), V4, P93, DOI 10.3389/fendo.2013.00093
   Tiwari S, 2007, J AM SOC NEPHROL, V18, P2661, DOI 10.1681/ASN.2006121410
   Vandanmagsar B, 2011, NAT MED, V17, P179, DOI 10.1038/nm.2279
   VENKATESAN N, 1995, METABOLISM, V44, P75, DOI 10.1016/0026-0495(95)90292-9
   Volcik KA, 2006, AM J EPIDEMIOL, V164, P342, DOI 10.1093/aje/kwj202
   Welsh N, 2005, DIABETES, V54, P3238, DOI 10.2337/diabetes.54.11.3238
   Wen HT, 2011, NAT IMMUNOL, V12, P408, DOI 10.1038/ni.2022
   White MF, 2003, SCIENCE, V302, P1710, DOI 10.1126/science.1092952
   WHITE MF, 1988, J BIOL CHEM, V263, P2969
   Wiseman DA, 2011, J BIOL CHEM, V286, DOI 10.1074/jbc.M110.214031
   WOLFF SP, 1987, BIOCHEM J, V245, P243, DOI 10.1042/bj2450243
   Xu CY, 2005, J CLIN INVEST, V115, P2656, DOI 10.1172/JCI26373
   Yano M, 2004, CLIN CHIM ACTA, V340, P93, DOI 10.1016/j.cccn.2003.09.020
   Ye J, 2000, MOL CELL, V6, P1355, DOI 10.1016/S1097-2765(00)00133-7
   ZHANG YY, 1994, NATURE, V372, P425, DOI 10.1038/372425a0
NR 139
TC 289
Z9 313
U1 4
U2 34
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2015
VL 2015
AR 181643
DI 10.1155/2015/181643
PG 15
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA CN6DI
UT WOS:000358523400001
PM 26257839
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Aydos, LR
   do Amaral, LA
   Jacobowski, AC
   de Souza, RS
   Parisotto, EB
   de Menezes, MB
   Bittencourt, FF
   Fernandes, ES
   Silva, IS
   Portugal, LC
   Oliveira, CG
   Masuko, GTS
   Cavalheiro, LF
   Nazário, CED
   dos Santos, EF
   Macedo, MLR
AF Aydos, Leonardo Recena
   do Amaral, Luane Aparecida
   Jacobowski, Ana Cristina
   de Souza, Roberta Serafim
   Parisotto, Eduardo Benedetti
   de Menezes, Mariana Biava
   Bittencourt Junior, Felipe Francisco
   Fernandes, Emely Schuindt
   Silva, Iandara Schettert
   Portugal, Luciane Candeloro
   Oliveira, Claudio Goncalves
   Senra Masuko, Gustavo Tsuyoshi
   Cavalheiro, Leandro Fontoura
   Domingues Nazario, Carlos Eduardo
   dos Santos, Elisvania Freitas
   Rodrigues Macedo, Maria Ligia
TI Buriti pulp oil did not improve high-fat diet-induced metabolic
   disorders in c57bl/6 mice
SO JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
LA English
DT Article
DE high&#8208; fat diet; metabolic syndrome; obesity
ID MAURITIA-FLEXUOSA L.; OXIDATIVE STRESS; LIVER-DISEASE; INFLAMMATION;
   DEPOSITION
AB Metabolic syndrome (MetS) and obesity are growing in many parts of the world, becoming public health problems. It is proposed that foods with functional properties can assist in the treatment of these diseases. Crude buriti pulp oil (BPO) is a food traditionally consumed by residents in the Pantanal, Cerrado and Brazilian Amazon. It is rich in oleic acid, tocopherols and carotenoids, emerging as a potential functional food. Thus, this study aimed to evaluate the effect of the supplementation of BPO on metabolic disorders caused by a high-fat diet. Four groups of C57BL6 mice were used, a lean group with AIN-93M diet and control oil supplementation, an obese group with a high-fat diet and control oil supplementation, and two obese groups with a high-fat diet and BPO supplementation in the amounts of 50 and 100 mg/kg. BPO worsened the metabolic state caused by the high-fat diet, worsening risk factors associated with MetS, as the abdominal circumference and retroperitoneal fat, serum levels of total cholesterol, uric acid, alanine transaminase, glucose and triglycerides, and renal fat, in addition to changes in glycaemic control and oxidative stress markers. C57BL/6 mice fed with a high-fat diet and supplemented with BPO presented a worsening in metabolic risk factors associated with MetS.
C1 [Aydos, Leonardo Recena; do Amaral, Luane Aparecida; de Souza, Roberta Serafim] Fed Univ Mato Grosso do Sul UFMS, Fac Med FAMED, Postgrad Program Hlth & Dev Midwest Reg, Campo Grande, MS, Brazil.
   [Aydos, Leonardo Recena; Jacobowski, Ana Cristina; de Souza, Roberta Serafim; Rodrigues Macedo, Maria Ligia] Fed Univ Mato Grosso do Sul UFMS, Prot Purificat Lab & Its Biol Funct LPPFB, Campo Grande, MS, Brazil.
   [Aydos, Leonardo Recena; do Amaral, Luane Aparecida; de Souza, Roberta Serafim; Silva, Iandara Schettert; Senra Masuko, Gustavo Tsuyoshi] Fed Univ Mato Grosso do Sul UFMS, Fac Med, Campo Grande, MS, Brazil.
   [Jacobowski, Ana Cristina; Parisotto, Eduardo Benedetti; de Menezes, Mariana Biava; dos Santos, Elisvania Freitas; Rodrigues Macedo, Maria Ligia] Fed Univ Mato Grosso do Sul UFMS, Fac Pharmaceut Sci Food & Nutr FACFAN, Campo Grande, MS, Brazil.
   [Bittencourt Junior, Felipe Francisco; Fernandes, Emely Schuindt] Univ Ctr Grande Dourados UNIGRAN, Fac Biol & Hlth Sci, Dourados, MS, Brazil.
   [Bittencourt Junior, Felipe Francisco; Fernandes, Emely Schuindt] Univ Ctr Grande Dourados UNIGRAN, Clin Anal Lab, Dourados, MS, Brazil.
   [Silva, Iandara Schettert] Fed Univ Mato Grosso do Sul UFMS, Lab Expt Dis Models, Campo Grande, MS, Brazil.
   [Portugal, Luciane Candeloro; Oliveira, Claudio Goncalves] Fed Univ Mato Grosso do Sul UFMS, Biosci Inst INBIO, Campo Grande, MS, Brazil.
   [Cavalheiro, Leandro Fontoura; Domingues Nazario, Carlos Eduardo] Fed Univ Mato Grosso do Sul UFMS, Inst Chem INQUI, Campo Grande, MS, Brazil.
C3 Universidade Federal de Mato Grosso do Sul; Universidade Federal de Mato
   Grosso do Sul; Universidade Federal de Mato Grosso do Sul; Universidade
   Federal de Mato Grosso do Sul; Universidade Federal de Mato Grosso do
   Sul; Universidade Federal de Mato Grosso do Sul; Universidade Federal de
   Mato Grosso do Sul
RP Aydos, LR (corresponding author), Fed Univ Mato Grosso do Sul UFMS, Fac Med FAMED, Postgrad Program Hlth & Dev Midwest Reg, Campo Grande, MS, Brazil.
EM leonardoaydos@gmail.com
RI Santos, Elisvania/AFV-3300-2022; Nazario, Carlos/G-9525-2012; Parisotto,
   Eduardo/V-5979-2019; Jacobowski, Ana Cristina/O-5045-2016; do Amaral,
   Luane Aparecida/K-4539-2018; Schettert Silva, Iandara/L-8525-2018
OI Jacobowski, Ana Cristina/0000-0001-8233-0713; Biava de Menezes,
   Mariana/0000-0001-5871-5285; Souza, Roberta/0000-0003-2538-6707; do
   Amaral, Luane Aparecida/0000-0002-1448-2472; Bittencourt Junior, Felipe
   Francisco/0000-0001-8801-9934; candeloro, luciane/0000-0001-9619-0010;
   Nazario, Carlos Eduardo Domingues/0000-0001-5097-3298; Schettert Silva,
   Iandara/0000-0001-9431-098X
FU Fundacao de Apoio ao Desenvolvimento do Ensino, Ciencia e Tecnologia do
   Estado de Mato Grosso do Sul; Coordenacao de Aperfeicoamento de Pessoal
   de Nivel Superior; Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico
FX Fundacao de Apoio ao Desenvolvimento do Ensino, Ciencia e Tecnologia do
   Estado de Mato Grosso do Sul; Coordenacao de Aperfeicoamento de Pessoal
   de Nivel Superior; Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico
CR Albuquerque S., 2005, Journal of the Brazilian Chemical Society, V16, P1113, DOI 10.1590/S0103-50532005000700004
   Alcala M, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0186579
   Aquino JD, 2015, MOLECULES, V20, P9054, DOI 10.3390/molecules20059054
   Aquino JD, 2012, J BRAZIL CHEM SOC, V23, P212
   Ayala JE, 2010, DIS MODEL MECH, V3, P525, DOI 10.1242/dmm.006239
   Besse-Patin Aurele, 2014, Int J Cell Biol, V2014, P519153, DOI 10.1155/2014/519153
   BEUTLER E, 1963, J LAB CLIN MED, V61, P882
   BIRD RP, 1984, METHOD ENZYMOL, V105, P299
   Borruel S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0114112
   Bosy-Westphal A, 2019, EUR J CLIN NUTR, V73, P209, DOI 10.1038/s41430-018-0323-7
   Christensen K, 2019, NUTRIENTS, V11, DOI 10.3390/nu11051101
   Cook NR, 2007, ARCH INTERN MED, V167, P1610, DOI 10.1001/archinte.167.15.1610
   Cymerys M., 2005, FRUTIFERAS PLANTAS U, P300
   da Silva HA, 2015, EINSTEIN-SAO PAULO, V13, P202
   Engin AB, 2017, ADV EXP MED BIOL, V960, P327, DOI 10.1007/978-3-319-48382-5_14
   FAO, 2019, SUSTAINABLE FOOD AND AGRICULTURE: AN INTEGRATED APPROACH, P1, DOI 10.1016/C2016-0-01212-3
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Ferramosca A, 2017, WORLD J GASTROENTERO, V23, P4146, DOI 10.3748/wjg.v23.i23.4146
   Ferreira E. L., 2008, PALM TREES ACRE HDB
   Filho A. B. G., 2001, BURITIZEIRO MAURITIA, P1
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Garcia-Quiroz A, 2003, INSTRUM SCI TECHNOL, V31, P93, DOI 10.1081/CI-120018411
   Johannsen DL, 2014, DIABETES CARE, V37, P2789, DOI 10.2337/dc14-0761
   Kanda Y, 2011, LIFE SCI, V89, P250, DOI 10.1016/j.lfs.2011.06.007
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Lane M.D., 2013, Encyclopedia of Biological Chemistry, VSecond, DOI DOI 10.1016/B978-0-12-378630-2.00089-X
   Masarone M, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/9547613
   Medeiros MC, 2015, INT J DEV NEUROSCI, V46, P7, DOI 10.1016/j.ijdevneu.2015.05.001
   Neri-Numa IA, 2018, FOOD RES INT, V103, P345, DOI 10.1016/j.foodres.2017.10.053
   Niki E, 2016, ARCH BIOCHEM BIOPHYS, V595, P19, DOI 10.1016/j.abb.2015.11.017
   Peris E, 2019, J BIOL CHEM, V294, P2340, DOI 10.1074/jbc.RA118.004253
   Pokorska-Spiewak M, 2017, BMC INFECT DIS, V17, DOI 10.1186/s12879-017-2462-1
   Priest C, 2019, NAT METAB, V1, P1177, DOI 10.1038/s42255-019-0145-5
   REEVES PG, 1993, J NUTR, V123, P1939, DOI 10.1093/jn/123.11.1939
   Rinella ME, 2015, JAMA-J AM MED ASSOC, V313, P2263, DOI 10.1001/jama.2015.5370
   Rutkowski JM, 2015, J CELL BIOL, V208, P501, DOI 10.1083/jcb.201409063
   Sierra H, 2015, J INVEST DERMATOL, V135, P612, DOI 10.1038/jid.2014.371
   Silva SM, 2009, J AM OIL CHEM SOC, V86, P611, DOI 10.1007/s11746-009-1400-9
   Slawik M, 2006, AGEING RES REV, V5, P144, DOI 10.1016/j.arr.2006.03.004
   Thaslima Nandhini J. S., 2018, ASIAN J PHARM CLIN R, V11, P400, DOI [10.22159/ajpcr.2018.v11i10.27233, DOI 10.22159/AJPCR.2018.V11I10.27233]
   Tormos KV, 2011, CELL METAB, V14, P537, DOI 10.1016/j.cmet.2011.08.007
   Tsuchida T, 2017, NAT REV GASTRO HEPAT, V14, P397, DOI 10.1038/nrgastro.2017.38
   Veeramachaneni S, 2008, J NUTR, V138, P1329, DOI 10.1093/jn/138.7.1329
   Vivekananthan D.P., 2003, OBSTET GYNECOLOGY, V102, P1086, DOI DOI 10.1097/00006250-200311000-00039
   Wang LJ, 2019, ANN NUTR METAB, V74, P156, DOI 10.1159/000496458
   World Health Organization, 2019, GLOB HLTH OBS GHO DA
   Xiao ML, 2019, EUR J NUTR, V58, P721, DOI 10.1007/s00394-018-1678-1
   Xu CF, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011578
   Zelber-Sagi S, 2006, LIVER INT, V26, P856, DOI 10.1111/j.1478-3231.2006.01311.x
NR 49
TC 4
Z9 4
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0931-2439
EI 1439-0396
J9 J ANIM PHYSIOL AN N
JI J. Anim. Physiol. Anim. Nutr.
PD MAR
PY 2021
VL 105
IS 2
BP 364
EP 375
DI 10.1111/jpn.13473
EA NOV 2020
PG 12
WC Agriculture, Dairy & Animal Science; Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Veterinary Sciences
GA QR0XN
UT WOS:000591399900001
PM 33226712
DA 2025-06-11
ER

PT J
AU Barazzoni, R
   Cappellari, GG
   Ragni, M
   Nisoli, E
AF Barazzoni, Rocco
   Cappellari, Gianluca Gortan
   Ragni, Maurizio
   Nisoli, Enzo
TI Insulin resistance in obesity: an overview of fundamental alterations
SO EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
LA English
DT Review
DE Obesity; Insulin resistance; Inflammation; Oxidative stress
ID BROWN ADIPOSE-TISSUE; MUSCLE OXIDATIVE CAPACITY; HUMAN SKELETAL-MUSCLE;
   TUMOR-NECROSIS-FACTOR; HIGH-FAT DIET; MITOCHONDRIAL DYSFUNCTION; GUT
   MICROBIOTA; ADIPONECTIN EXPRESSION; MOLECULAR-MECHANISMS; METABOLIC
   SYNDROME
AB Obesity is a major health risk factor, and obesity-induced morbidity and complications account for huge costs for affected individuals, families, healthcare systems, and society at large. In particular, obesity is strongly associated with the development of insulin resistance, which in turn plays a key role in the pathogenesis of obesity-associated cardiometabolic complications, including metabolic syndrome components, type 2 diabetes, and cardiovascular diseases. Insulin sensitive tissues, including adipose tissue, skeletal muscle, and liver, are profoundly affected by obesity both at biomolecular and functional levels. Altered adipose organ function may play a fundamental pathogenetic role once fat accumulation has ensued. Modulation of insulin sensitivity appears to be, at least in part, related to changes in redox balance and oxidative stress as well as inflammation, with a relevant underlying role for mitochondrial dysfunction that may exacerbate these alterations. Nutrients and substrates as well as systems involved in host-nutrient interactions, including gut microbiota, have been also identified as modulators of metabolic pathways controlling insulin action. This review aims at providing an overview of these concepts and their potential inter-relationships in the development of insulin resistance, with particular regard to changes in adipose organ and skeletal muscle.
C1 [Barazzoni, Rocco; Cappellari, Gianluca Gortan] Univ Trieste, Dept Med Surg & Hlth Sci, Str Fiume 447, I-34149 Trieste, Italy.
   [Barazzoni, Rocco; Cappellari, Gianluca Gortan] Azienda Sanit Univ Integrata Trieste ASUITS, Trieste, Italy.
   [Ragni, Maurizio; Nisoli, Enzo] Univ Milan, Ctr Study & Res Obes, Dept Med Biotechnol & Translat Med, Via Vanvitelli 32, I-20129 Milan, Italy.
C3 University of Trieste; University of Trieste; University Trieste
   Hospital; University of Milan
RP Barazzoni, R (corresponding author), Univ Trieste, Dept Med Surg & Hlth Sci, Str Fiume 447, I-34149 Trieste, Italy.; Barazzoni, R (corresponding author), Azienda Sanit Univ Integrata Trieste ASUITS, Trieste, Italy.; Nisoli, E (corresponding author), Univ Milan, Ctr Study & Res Obes, Dept Med Biotechnol & Translat Med, Via Vanvitelli 32, I-20129 Milan, Italy.
EM barazzon@units.it; enzo.nisoli@unimi.it
RI Nisoli, Enzo/D-6526-2014; Cappellari, Gianluca/B-7132-2013; Ragni,
   Maurizio/AAB-1527-2020
OI Gortan Cappellari, Gianluca/0000-0002-0438-5003; Ragni,
   Maurizio/0000-0001-6548-741X
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Anderson EJ, 2009, J CLIN INVEST, V119, P573, DOI 10.1172/JCI37048
   Barazzoni R, 2005, ENDOCRINOLOGY, V146, P2098, DOI 10.1210/en.2004-1396
   Barazzoni R, 2017, CLIN NUTR, V36, P775, DOI 10.1016/j.clnu.2016.05.017
   Barazzoni R, 2004, CURR OPIN CLIN NUTR, V7, P97, DOI 10.1097/00075197-200401000-00015
   Barazzoni R, 2012, DIABETOLOGIA, V55, P773, DOI 10.1007/s00125-011-2396-x
   Barazzoni R, 2017, J CACHEXIA SARCOPENI
   Barazzoni R, 2008, CLIN NUTR, V27, P142, DOI 10.1016/j.clnu.2007.06.013
   Barazzoni R, 2007, AM J PHYSIOL-REG I, V293, pR47, DOI 10.1152/ajpregu.00745.2006
   Barazzoni R, 2013, OBESITY, V21, P718, DOI 10.1002/oby.20272
   Barazzoni R, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026224
   Bifari F, 2017, GENES NUTR, V12, DOI 10.1186/s12263-017-0582-2
   Bikman BT, 2011, J CLIN INVEST, V121, P4222, DOI 10.1172/JCI57144
   Birnbaum MJ, 2001, J CLIN INVEST, V108, P655, DOI 10.1172/JCI200113714
   BODEN G, 1995, J CLIN INVEST, V96, P1261, DOI 10.1172/JCI118160
   BODEN G, 1991, J CLIN INVEST, V88, P960, DOI 10.1172/JCI115399
   Boden G, 2011, CURR OPIN ENDOCRINOL, V18, P139, DOI 10.1097/MED.0b013e3283444b09
   Bondia-Pons I, 2012, J PHYSIOL BIOCHEM, V68, P701, DOI 10.1007/s13105-012-0154-2
   Bonnard C, 2008, J CLIN INVEST, V118, P789, DOI 10.1172/JCI32601
   Bravard A, 2011, AM J PHYSIOL-ENDOC M, V300, pE581, DOI 10.1152/ajpendo.00455.2010
   Breen DM, 2011, CURR VASC PHARMACOL, V9, P321
   Buchner DA, 2011, OBESITY, V19, P917, DOI 10.1038/oby.2010.214
   Cani PD, 2007, CURR OPIN CLIN NUTR, V10, P729, DOI 10.1097/MCO.0b013e3282efdebb
   Cani PD, 2014, NAT REV ENDOCRINOL, V10, P74, DOI 10.1038/nrendo.2013.240
   Cani PD, 2009, CURR PHARM DESIGN, V15, P1546, DOI 10.2174/138161209788168164
   Cappellari GG, 2016, DIABETES, V65, P874, DOI 10.2337/db15-1019
   Chavez AO, 2010, J CLIN ENDOCR METAB, V95, P422, DOI 10.1210/jc.2009-1387
   CHEN M, 1976, J CLIN ENDOCR METAB, V42, P1168, DOI 10.1210/jcem-42-6-1168
   Cohen P, 2015, DIABETES, V64, P2346, DOI 10.2337/db15-0318
   Cotillard A, 2013, NATURE, V500, P585, DOI 10.1038/nature12480
   de Mello AH, 2018, LIFE SCI, V192, P26, DOI 10.1016/j.lfs.2017.11.019
   Draznin B, 1997, CLIN RES DIABETES OB
   Duncan RE, 2007, ANNU REV NUTR, V27, P79, DOI 10.1146/annurev.nutr.27.061406.093734
   Eldor R, 2013, DIABETES CARE, V36, pS162, DOI 10.2337/dcS13-2003
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Geurts L, 2014, BENEF MICROBES, V5, P3, DOI 10.3920/BM2012.0065
   Giordano A, 2016, NAT REV DRUG DISCOV, V15, P405, DOI 10.1038/nrd.2016.31
   Giordano A, 2014, EUR J ENDOCRINOL, V170, pR159, DOI 10.1530/EJE-13-0945
   Giordano A, 2013, J LIPID RES, V54, P2423, DOI 10.1194/jlr.M038638
   Goldstein BJ, 2005, DIABETES, V54, P311, DOI 10.2337/diabetes.54.2.311
   Gómez-Serrano M, 2017, REDOX BIOL, V11, P415, DOI 10.1016/j.redox.2016.12.013
   Guarnieri G, 2009, J RENAL NUTR, V19, P20, DOI 10.1053/j.jrn.2008.11.014
   Guo W, 2007, AM J PHYSIOL-ENDOC M, V293, pE576, DOI 10.1152/ajpendo.00523.2006
   Gustafson B, 2015, TRENDS ENDOCRIN MET, V26, P193, DOI 10.1016/j.tem.2015.01.006
   Hocking S, 2013, ENDOCR REV, V34, P463, DOI 10.1210/er.2012-1041
   Jans A, 2012, AM J CLIN NUTR, V95, P825, DOI 10.3945/ajcn.111.028787
   Jheng HF, 2015, ANN NY ACAD SCI, V1350, P82, DOI 10.1111/nyas.12863
   Kadowaki T, 2006, J CLIN INVEST, V116, P1784, DOI 10.1172/JCI29126
   KERN PA, 1995, J CLIN INVEST, V95, P2111, DOI 10.1172/JCI117899
   Kern PA, 2003, DIABETES, V52, P1779, DOI 10.2337/diabetes.52.7.1779
   Kim JK, 2001, J CLIN INVEST, V108, P437, DOI 10.1172/JCI11559
   Kimura I, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms2852
   Kong XC, 2015, DIABETES, V64, P393, DOI 10.2337/db14-0395
   Kuo FC, 2017, METAB SYNDR RELAT D, V15, P187, DOI 10.1089/met.2016.0135
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   LUZI L, 1993, DIABETES, V42, P1868, DOI 10.2337/diabetes.42.12.1868
   Marseglia L, 2015, INT J MOL SCI, V16, P378, DOI 10.3390/ijms16010378
   Martínez-Sánchez N, 2017, J ENDOCRINOL, V232, P351, DOI 10.1530/JOE-16-0425
   Mittendorfer B, 2011, CURR OPIN CLIN NUTR, V14, P535, DOI 10.1097/MCO.0b013e32834ad8b6
   Mootha VK, 2003, NAT GENET, V34, P267, DOI 10.1038/ng1180
   Morino K, 2006, DIABETES, V55, pS9, DOI 10.2337/db06-S002
   Nair KS, 2008, DIABETES, V57, P1166, DOI 10.2337/db07-1556
   Nicholson JK, 2012, SCIENCE, V336, P1262, DOI 10.1126/science.1223813
   Ostergård T, 2006, AM J PHYSIOL-ENDOC M, V290, pE998, DOI 10.1152/ajpendo.00012.2005
   Paolisso G, 1996, J CLIN ENDOCR METAB, V81, P4244, DOI 10.1210/jc.81.12.4244
   Pataky Z, 2010, INT J OBESITY, V34, pS18, DOI 10.1038/ijo.2010.235
   Pepping JK, 2013, AM J PHYSIOL-ENDOC M, V304, pE392, DOI 10.1152/ajpendo.00398.2012
   Popkin BM, 2012, NUTR REV, V70, P3, DOI 10.1111/j.1753-4887.2011.00456.x
   Poulos SP, 2010, MOL CELL ENDOCRINOL, V323, P20, DOI 10.1016/j.mce.2009.12.011
   Rachek LI, 2007, ENDOCRINOLOGY, V148, P293, DOI 10.1210/en.2006-0998
   Ramage LE, 2016, CELL METAB, V24, P130, DOI 10.1016/j.cmet.2016.06.011
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   Richardson DK, 2005, J BIOL CHEM, V280, P10290, DOI 10.1074/jbc.M408985200
   Ritter O, 2015, J MOL MED, V93, P831, DOI 10.1007/s00109-015-1310-2
   Rowland I, 2017, EUR J NUTR
   Samuel VT, 2010, LANCET, V375, P2267, DOI 10.1016/S0140-6736(10)60408-4
   Sarparanta J, 2017, CURR DIABETES REV, V13, P352, DOI 10.2174/1573399812666160217122530
   Semolic A., 2017, FASEB J
   Sethi JK, 2007, J LIPID RES, V48, P1253, DOI 10.1194/jlr.R700005-JLR200
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Short KR, 2003, DIABETES, V52, P1888, DOI 10.2337/diabetes.52.8.1888
   Shulman GI, 2014, NEW ENGL J MED, V371, P2237
   Storlien LH, 1996, DIABETOLOGIA, V39, P621, DOI 10.1007/BF00418533
   Stump CS, 2003, P NATL ACAD SCI USA, V100, P7996, DOI 10.1073/pnas.1332551100
   Tahrani AA, 2011, LANCET, V378, P182, DOI 10.1016/S0140-6736(11)60207-9
   Takamura T, 2008, OBESITY, V16, P2601, DOI 10.1038/oby.2008.419
   Toledo FGS, 2008, DIABETES, V57, P987, DOI 10.2337/db07-1429
   Trayhurn P, 2016, DIABETES, V65, P1158, DOI 10.2337/dbi16-0002
   Valerio A, 2006, J CLIN INVEST, V116, P2791, DOI [10.1172/JCI28570, 10.1172/JCI28570.]
   Weiner J, 2016, SCI REP-UK, V6, DOI 10.1038/srep38124
   Weyer C, 2000, DIABETOLOGIA, V43, P1498, DOI 10.1007/s001250051560
   Wilcox Gisela, 2005, Clin Biochem Rev, V26, P19
   Williams KJ, 2016, ATHEROSCLEROSIS, V247, P225, DOI 10.1016/j.atherosclerosis.2016.02.004
   Yamauchi T, 2002, NAT MED, V8, P1288, DOI 10.1038/nm788
   Yuan XX, 2017, FASEB J, V31, P333, DOI [10.1096/fj.201600459RR, 10.1096/fj.201600459rr]
   Yuzefovych L, 2010, AM J PHYSIOL-ENDOC M, V299, pE1096, DOI 10.1152/ajpendo.00238.2010
   Zanetti M, 2008, J RENAL NUTR, V18, P70, DOI 10.1053/j.jrn.2007.10.015
NR 97
TC 247
Z9 271
U1 9
U2 110
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1124-4909
EI 1590-1262
J9 EAT WEIGHT DISORD-ST
JI Eat. Weight Disord.-Stud. Anorex.
PD APR
PY 2018
VL 23
IS 2
BP 149
EP 157
DI 10.1007/s40519-018-0481-6
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA GA1NG
UT WOS:000428082700002
PM 29397563
OA Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Bulló, M
   Lamuela-Raventós, R
   Salas-Salvadó, J
AF Bullo, Monica
   Lamuela-Raventos, Rosa
   Salas-Salvado, Jordi
TI Mediterranean Diet and Oxidation: Nuts and Olive Oil as Important
   Sources of Fat and Antioxidants
SO CURRENT TOPICS IN MEDICINAL CHEMISTRY
LA English
DT Review
DE Nuts; virgin olive oil; oxidative stress; antioxidants; mediterranean
   diet
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; MINOR-POLAR-COMPOUNDS;
   FACTOR-KAPPA-B; PLATELET-AGGREGATION; PHENOLIC-COMPOUNDS; DNA-DAMAGE;
   ENDOTHELIAL FUNCTION; ALPHA-TOCOPHEROL; LIPID PROFILE
AB Oxidative stress has been involved in the aetiology of hypertension, insulin resistance, the metabolic syndrome, cardiovascular disease and other chronic conditions. Several epidemiological studies suggest that a diet rich in natural antioxidants is associated with protective effects against major diseases, especially cardiovascular disease. The Mediterranean diet is rich in fat and foods with important antioxidant properties, such as fruits and vegetables, olive oil, and nuts. In this review we focus on epidemiological evidence and clinical trials that relate the Mediterranean diet with oxidative stress markers. We focus our review on two important Mediterranean vegetable sources of potentially oxidized fat-olive oil and nuts.
C1 [Bullo, Monica; Salas-Salvado, Jordi] Univ Rovira & Virgili, Hosp Univ St Joan, Dept Bioquim & Biotecnol, Unitat Nutr Humana,IISPV, E-43201 Reus, Spain.
   [Lamuela-Raventos, Rosa] Univ Barcelona, Fac Farm, Dept Nutr & Bromatol, E-08028 Barcelona, Spain.
   [Bullo, Monica; Lamuela-Raventos, Rosa; Salas-Salvado, Jordi] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CB06 03, Madrid, Spain.
C3 Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV); University of Barcelona; Instituto de Salud Carlos III;
   CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN
RP Salas-Salvadó, J (corresponding author), Univ Rovira & Virgili, Human Nutr Unit, Fac Med, C St Llorenc 21, E-43201 Reus, Spain.
EM jordi.salas@urv.cat
RI Bullo, Monica/F-2925-2016; Salas-Salvado, Jordi/C-7229-2017;
   Lamuela-Raventos, Rosa M/F-3986-2016
OI Bullo, Monica/0000-0002-0218-7046; Salas-Salvado,
   Jordi/0000-0003-2700-7459; Lamuela-Raventos, Rosa M/0000-0002-1287-4560
FU Spanish Ministry of Health (Instituto de Salud Carlos III) [G03/140,
   RD06/0045]; Centre Catala de la Nutricio (CCNIEC), Institut d'Estudis
   Catalans, Barcelona, Spain; Spanish Ministry of Health (Instituto de
   Salud Carlos III, Fondo de Investigaciones Sanitarias) [G03/140,
   RD06/0045, PI051839, CB06/03]
FX This study was funded, in part, by the Spanish Ministry of Health
   (Instituto de Salud Carlos III), G03/140, and RD06/0045, and the Centre
   Catala de la Nutricio (CCNIEC), Institut d'Estudis Catalans, Barcelona,
   Spain. This study was partly funded by the Spanish Ministry of Health
   (Instituto de Salud Carlos III, Fondo de Investigaciones Sanitarias)
   under projects PI051839, G03/140, RD06/0045 and CB06/03. CIBERobn is an
   Instituto de Salud Carlos III initiative.
CR Alasalvar C, 2009, EUR J LIPID SCI TECH, V111, P1056, DOI 10.1002/ejlt.200900098
   Ambring A, 2004, CLIN SCI, V106, P519, DOI 10.1042/CS20030315
   Anderson KJ, 2001, J NUTR, V131, P2837, DOI 10.1093/jn/131.11.2837
   Martinez-Gonzalez MA, 2009, NUTR REV, V67, pS111, DOI 10.1111/j.1753-4887.2009.00172.x
   [Anonymous], DAT PROANTH CONT SEL
   Moreno JA, 2008, BRIT J NUTR, V100, P569, DOI 10.1017/S0007114508911508
   Aronis P, 2007, J MED FOOD, V10, P511, DOI 10.1089/jmf.2006.235
   Bakkalbasi E, 2009, CRIT REV FOOD SCI, V49, P283, DOI 10.1080/10408390802064404
   BERRY EM, 1992, AM J CLIN NUTR, V56, P394, DOI 10.1093/ajcn/56.2.394
   Bertelli AAE, 2001, THERAPIE, V56, P613
   Bogani P, 2007, ATHEROSCLEROSIS, V190, P181, DOI 10.1016/j.atherosclerosis.2006.01.011
   BONANOME A, 1992, ARTERIOSCLER THROMB, V12, P529, DOI 10.1161/01.ATV.12.4.529
   Brunelleschi S, 2007, PHARMACOL RES, V56, P542, DOI 10.1016/j.phrs.2007.10.001
   Buchner N, 2006, RAPID COMMUN MASS SP, V20, P3229, DOI 10.1002/rcm.2720
   Bulló M, 2010, NUTRITION, V26, P823, DOI 10.1016/j.nut.2009.09.002
   Buscemi S, 2009, EUR J CLIN INVEST, V39, P339, DOI 10.1111/j.1365-2362.2009.02091.x
   Caemmerer B, 2009, LWT-FOOD SCI TECHNOL, V42, P545, DOI 10.1016/j.lwt.2008.08.003
   Calder PC, 2006, AM J CLIN NUTR, V83, p1505S, DOI 10.1093/ajcn/83.6.1505S
   Canales A, 2007, J AM COLL NUTR, V26, P225, DOI 10.1080/07315724.2007.10719605
   Carluccio MA, 2003, ARTERIOSCL THROM VAS, V23, P622, DOI 10.1161/01.ATV.0000062884.69432.A0
   Carr AC, 2000, BIOCHEM J, V346, P491, DOI 10.1042/0264-6021:3460491
   Carrasco-Pancorbo A, 2005, J AGR FOOD CHEM, V53, P8918, DOI 10.1021/jf0515680
   Chen CYO, 2008, ASIA PAC J CLIN NUTR, V17, P329
   Chen CY, 2007, J NUTR BIOCHEM, V18, P785, DOI 10.1016/j.jnutbio.2006.12.015
   Chen CY, 2005, J NUTR, V135, P1366, DOI 10.1093/jn/135.6.1366
   Cicerale S, 2009, CRIT REV FOOD SCI, V49, P218, DOI 10.1080/10408390701856223
   Corona G, 2009, TOXICOL IND HEALTH, V25, P285, DOI 10.1177/0748233709102951
   Cortés B, 2006, J AM COLL CARDIOL, V48, P1666, DOI 10.1016/j.jacc.2006.06.057
   Covas MI, 2006, ANN INTERN MED, V145, P333, DOI 10.7326/0003-4819-145-5-200609050-00006
   Dai J, 2008, AM J CLIN NUTR, V88, P1364, DOI 10.3945/ajcn.2008.26528
   Davis JP, 2010, FOOD CHEM, V119, P539, DOI 10.1016/j.foodchem.2009.06.057
   Davis L, 2007, EUR J NUTR, V46, P155, DOI 10.1007/s00394-007-0647-x
   De Caterina R, 2000, AM J CLIN NUTR, V71, p213S, DOI 10.1093/ajcn/71.1.213S
   de la Puerta R, 2000, Z NATURFORSCH C, V55, P814
   De La Torre-Carbot K, 2005, J AGR FOOD CHEM, V53, P4331, DOI 10.1021/jf0501948
   Dehmlow C, 1996, HEPATOLOGY, V23, P749, DOI 10.1002/hep.510230415
   Dell'Agli M, 2008, BRIT J NUTR, V99, P945, DOI 10.1017/S0007114507837470
   Dell'Agli M, 2006, J AGR FOOD CHEM, V54, P3259, DOI 10.1021/jf0529161
   Di Santo A, 2003, J THROMB HAEMOST, V1, P1089, DOI 10.1046/j.1538-7836.2003.00217.x
   Dobrydneva Y, 1999, BRIT J PHARMACOL, V128, P149, DOI 10.1038/sj.bjp.0702749
   Esti M, 1998, J AGR FOOD CHEM, V46, P32, DOI 10.1021/jf970391+
   Estruch R, 2006, ANN INTERN MED, V145, P1, DOI 10.7326/0003-4819-145-1-200607040-00004
   Fernández-Jarne E, 2002, INT J EPIDEMIOL, V31, P474, DOI 10.1093/ije/31.2.474
   Fitó M, 2005, ATHEROSCLEROSIS, V181, P149, DOI 10.1016/j.atherosclerosis.2004.12.036
   Fito Montserrat, 2007, Ann Ist Super Sanita, V43, P375
   Fitó M, 2007, ARCH INTERN MED, V167, P1195, DOI 10.1001/archinte.167.11.1195
   FRANKEL EN, 2005, LIPID OXIDATION, P204
   FRANKEL EN, 2007, ANTIOXIDANTS FOOD BI, P117
   FRIESENECKER B, 1994, INT J MICROCIRC, V14, P50, DOI 10.1159/000178206
   Gentile C, 2007, J AGR FOOD CHEM, V55, P643, DOI 10.1021/jf062533i
   Gimeno E, 2002, FOOD CHEM, V78, P207, DOI 10.1016/S0308-8146(01)00399-5
   Gimeno E, 2007, BRIT J NUTR, V98, P1243, DOI 10.1017/S0007114507778698
   Godichaud S, 2000, HEPATOLOGY, V31, P922, DOI 10.1053/he.2000.5848
   Correa JAG, 2009, BRIT J NUTR, V101, P1157, DOI 10.1017/S0007114508061539
   GRAMENZI A, 1990, BMJ-BRIT MED J, V300, P771, DOI 10.1136/bmj.300.6727.771
   Griel AE, 2006, BRIT J NUTR, V96, pS68, DOI 10.1017/BJN20061866
   Haddad E, 2006, NUTR RES, V26, P397, DOI 10.1016/j.nutres.2006.06.022
   Hagfors L, 2003, NUTR J, V2, DOI 10.1186/1475-2891-2-5
   Hargrove RL, 2001, J NUTR, V131, P1758, DOI 10.1093/jn/131.6.1758
   Hubbard GP, 2006, BRIT J NUTR, V96, P482, DOI 10.1079/BJN20061831
   Hubbard GP, 2003, P NUTR SOC, V62, P469, DOI 10.1079/PNS2003253
   Hung SL, 2006, J PERIODONTOL, V77, P579, DOI 10.1902/jop.2006.050217
   Hyson DA, 2002, J NUTR, V132, P703, DOI 10.1093/jn/132.4.703
   Iwamoto M, 2002, EUR J CLIN NUTR, V56, P629, DOI 10.1038/sj.ejcn.1601400
   Jenkins DJA, 2008, J NUTR, V138, P908, DOI 10.1093/jn/138.5.908
   Jenkins DJA, 2002, CIRCULATION, V106, P1327, DOI 10.1161/01.CIR.0000028421.91733.20
   Jia XD, 2006, NUTR CANCER, V54, P179, DOI 10.1207/s15327914nc5402_4
   Jimenez-Gomez Yolanda, 2009, Atherosclerosis, V204, pe70, DOI 10.1016/j.atherosclerosis.2008.09.011
   KAKISHITA E, 1990, THROMB RES, V60, P489, DOI 10.1016/0049-3848(90)90233-3
   Karantonis HC, 2006, DIABETES RES CLIN PR, V72, P33, DOI 10.1016/j.diabres.2005.09.003
   KARLSSON S, 2009, BR J NUTR, P1
   KATAN MB, 1995, AM J CLIN NUTR, V61, p1368S, DOI 10.1093/ajcn/61.6.1368S
   Kelly JH, 2006, BRIT J NUTR, V96, pS61, DOI 10.1017/BJN20061865
   KEYS A, 1986, AM J EPIDEMIOL, V124, P903, DOI 10.1093/oxfordjournals.aje.a114480
   Kim HP, 1998, PROSTAG LEUKOTR ESS, V58, P17, DOI 10.1016/S0952-3278(98)90125-9
   King JG, 2008, J NUTR, V138, p1736S, DOI 10.1093/jn/138.9.1736S
   Kocyigit A, 2006, NUTR METAB CARDIOVAS, V16, P202, DOI 10.1016/j.numecd.2005.08.004
   Kornsteiner M, 2006, FOOD CHEM, V98, P381, DOI 10.1016/j.foodchem.2005.07.033
   Lapointe A, 2005, J NUTR, V135, P410, DOI 10.1093/jn/135.3.410
   LAUGHTON MJ, 1991, BIOCHEM PHARMACOL, V42, P1673, DOI 10.1016/0006-2952(91)90501-U
   Leighton F, 1999, DRUG EXP CLIN RES, V25, P133
   Lerma-García MJ, 2009, J AGR FOOD CHEM, V57, P7834, DOI 10.1021/jf901346n
   Li N, 2007, J NUTR, V137, P2717, DOI 10.1093/jn/137.12.2717
   López-Miranda J, 2000, MED CLIN-BARCELONA, V115, P361, DOI 10.1016/S0025-7753(00)71561-2
   Lopez-Miranda J, 2007, MOL NUTR FOOD RES, V51, P1249, DOI 10.1002/mnfr.200600307
   López-Uriarte P, 2010, CLIN NUTR, V29, P373, DOI 10.1016/j.clnu.2009.12.008
   López-Uriarte P, 2009, NUTR REV, V67, P497, DOI 10.1111/j.1753-4887.2009.00223.x
   Lou HX, 2001, PLANTA MED, V67, P345, DOI 10.1055/s-2001-14319
   Ma Q, 2003, MOL PHARMACOL, V64, P211, DOI 10.1124/mol.64.2.211
   Manna C, 1997, J NUTR, V127, P286, DOI 10.1093/jn/127.2.286
   Marrugat J, 2004, EUR J NUTR, V43, P140, DOI 10.1007/s00394-004-0452-8
   Masella R, 2004, J NUTR, V134, P785, DOI 10.1093/jn/134.4.785
   Masella R, 2001, LIPIDS, V36, P1195, DOI 10.1007/s11745-001-0832-3
   Mata P, 1997, ARTERIOSCL THROM VAS, V17, P2088, DOI 10.1161/01.ATV.17.10.2088
   Mateos R, 2004, J AM OIL CHEM SOC, V81, P71, DOI 10.1007/s11746-004-0859-x
   Mekhfi H, 2006, PHYTOTHER RES, V20, P135, DOI 10.1002/ptr.1822
   Mena MP, 2009, AM J CLIN NUTR, V89, P248, DOI 10.3945/ajcn.2008.26094
   Milbury PE, 2006, J AGR FOOD CHEM, V54, P5027, DOI 10.1021/jf0603937
   Monagas M, 2009, J AGR FOOD CHEM, V57, P10590, DOI 10.1021/jf901391a
   Monagas M, 2009, BRIT J NUTR, V102, P201, DOI 10.1017/S0007114508162110
   Moschandreas J, 2002, EUR J CLIN NUTR, V56, P1024, DOI 10.1038/sj.ejcn.1601444
   Mukuddem-Petersen J, 2005, J NUTR, V135, P2082, DOI 10.1093/jn/135.9.2082
   Muñoz S, 2001, J LIPID RES, V42, P2069
   Murphy KJ, 2003, AM J CLIN NUTR, V77, P1466, DOI 10.1093/ajcn/77.6.1466
   O'Dowd Y, 2004, BIOCHEM PHARMACOL, V68, P2003, DOI 10.1016/j.bcp.2004.06.023
   Okogeri O, 2002, J AGR FOOD CHEM, V50, P1077, DOI 10.1021/jf010895e
   Owen RW, 2000, EUR J CANCER, V36, P1235, DOI 10.1016/S0959-8049(00)00103-9
   Pachco YA, 2008, J NUTR BIOCHEM, V19, P200, DOI 10.1016/j.jnutbio.2007.03.002
   Panagiotakos DB, 2004, ATHEROSCLEROSIS, V173, P353, DOI 10.1016/j.atherosclerosis.2003.12.031
   Papoutsi Z, 2008, BRIT J NUTR, V99, P715, DOI 10.1017/S0007114507837421
   Perez-Martinez P, 2011, NUTR METAB CARDIOVAS, V21, P39, DOI 10.1016/j.numecd.2009.07.008
   PETRONI A, 1995, THROMB RES, V78, P151, DOI 10.1016/0049-3848(95)00043-7
   Pitsavos C, 2005, AM J CLIN NUTR, V82, P694, DOI 10.1093/ajcn/82.3.694
   Pitsavos C, 2006, NUTR METAB CARDIOVAS, V16, P91, DOI 10.1016/j.numecd.2005.04.004
   Rajaram S, 2010, BRIT J NUTR, V103, P907, DOI 10.1017/S0007114509992480
   Ramirez-Tortosa MC, 1999, J NUTR, V129, P2177, DOI 10.1093/jn/129.12.2177
   REAVEN P, 1991, AM J CLIN NUTR, V54, P701, DOI 10.1093/ajcn/54.4.701
   Rohn S, 2007, J AGR FOOD CHEM, V55, P1568, DOI 10.1021/jf063221i
   Romani A, 2007, J AGR FOOD CHEM, V55, P1315, DOI 10.1021/jf062335r
   Ros E, 2004, CIRCULATION, V109, P1609, DOI 10.1161/01.CIR.0000124477.91474.FF
   Ros E, 2006, BRIT J NUTR, V96, pS29, DOI 10.1017/BJN20061861
   ROSE GA, 1965, BMJ-BRIT MED J, V1, P1531, DOI 10.1136/bmj.1.5449.1531
   Sabaté J, 2009, AM J CLIN NUTR, V89, pS1643, DOI 10.3945/ajcn.2009.26736Q
   SALAH N, 1995, ARCH BIOCHEM BIOPHYS, V322, P339, DOI 10.1006/abbi.1995.1473
   Salvini S, 2006, BRIT J NUTR, V95, P742, DOI 10.1079/BJN20051674
   Saura-Calixto F, 2006, FOOD CHEM, V94, P442, DOI 10.1016/j.foodchem.2004.11.033
   Scholz S, 2007, INT J VITAM NUTR RES, V77, P224, DOI 10.1024/0300-9831.77.3.224
   Shahidi F, 2007, J AGR FOOD CHEM, V55, P1212, DOI 10.1021/jf062472o
   SIRTORI CR, 1986, AM J CLIN NUTR, V44, P635, DOI 10.1093/ajcn/44.5.635
   SOFI F, 2008, BMJ-BRIT MED J, V11, pA1344
   Stachowska E, 2005, BRIT J NUTR, V93, P345, DOI 10.1079/BJN20051374
   Sung B, 2008, BLOOD, V111, P4880, DOI 10.1182/blood-2007-10-117994
   Tapsell LC, 2004, DIABETES CARE, V27, P2777, DOI 10.2337/diacare.27.12.2777
   Tawfik MS, 1999, FOOD CHEM, V64, P451, DOI 10.1016/S0308-8146(97)00202-1
   Thomson CD, 2008, AM J CLIN NUTR, V87, P379, DOI 10.1093/ajcn/87.2.379
   Tokusoglu Ö, 2005, J AGR FOOD CHEM, V53, P5003, DOI 10.1021/jf050496+
   TORDERA M, 1994, Z NATURFORSCH C, V49, P235
   TZONOU A, 1993, EPIDEMIOLOGY, V4, P511, DOI 10.1097/00001648-199311000-00006
   Urpi-Sarda M, 2009, J AGR FOOD CHEM, V57, P10134, DOI 10.1021/jf901450z
   *USDA, 2006, DAT FLAV CONT SEL FO
   VANACKER SABE, 1995, BIOCHEM BIOPH RES CO, V214, P755, DOI 10.1006/bbrc.1995.2350
   Vicario IM, 1998, ANN NUTR METAB, V42, P160, DOI 10.1159/000012729
   Visioli F, 2005, EUR J NUTR, V44, P121, DOI 10.1007/s00394-004-0504-0
   Visioli F, 2000, FEBS LETT, V468, P159, DOI 10.1016/S0014-5793(00)01216-3
   Visioli F, 1998, BIOCHEM BIOPH RES CO, V247, P60, DOI 10.1006/bbrc.1998.8735
   Vissers MN, 2004, EUR J CLIN NUTR, V58, P955, DOI 10.1038/sj.ejcn.1601917
   Vissers MN, 2001, EUR J CLIN NUTR, V55, P334, DOI 10.1038/sj.ejcn.1601161
   Vita JA, 2005, AM J CLIN NUTR, V81, p292S, DOI 10.1093/ajcn/81.1.292S
   Wagner KH, 2004, ANN NUTR METAB, V48, P169, DOI 10.1159/000079555
   Wang ZR, 2002, CHINESE MED J-PEKING, V115, P378
   Weinbrenner T, 2003, ATHEROSCLEROSIS, V168, P99, DOI 10.1016/S0021-9150(03)00053-4
   Wijeratne SSK, 2006, J AGR FOOD CHEM, V54, P312, DOI 10.1021/jf051692j
   Yaacoub R, 2008, J AGR FOOD CHEM, V56, P7082, DOI 10.1021/jf800808d
   Yang CS, 2008, MOL NUTR FOOD RES, V52, pS139, DOI 10.1002/mnfr.200700234
   Yu JM, 2006, J FOOD COMPOS ANAL, V19, P364, DOI 10.1016/j.jfca.2005.08.003
   Zambón D, 2000, ANN INTERN MED, V132, P538, DOI 10.7326/0003-4819-132-7-200004040-00039
   Zhang XM, 2009, N-S ARCH PHARMACOL, V379, P581, DOI 10.1007/s00210-009-0399-7
NR 157
TC 131
Z9 141
U1 1
U2 56
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1568-0266
EI 1873-5294
J9 CURR TOP MED CHEM
JI Curr. Top. Med. Chem.
PD JUL
PY 2011
VL 11
IS 14
BP 1797
EP 1810
DI 10.2174/156802611796235062
PG 14
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 792PO
UT WOS:000292759700005
PM 21506929
DA 2025-06-11
ER

PT J
AU Mollace, R
   Macrì, R
   Tavernese, A
   Gliozzi, M
   Musolino, V
   Carresi, C
   Maiuolo, J
   Fini, M
   Volterrani, M
   Mollace, V
AF Mollace, Rocco
   Macri, Roberta
   Tavernese, Annamaria
   Gliozzi, Micaela
   Musolino, Vincenzo
   Carresi, Cristina
   Maiuolo, Jessica
   Fini, Massimo
   Volterrani, Maurizio
   Mollace, Vincenzo
TI Comparative Effect of Bergamot Polyphenolic Fraction and Red Yeast Rice
   Extract in Rats Fed a Hyperlipidemic Diet: Role of Antioxidant
   Properties and PCSK9 Expression
SO NUTRIENTS
LA English
DT Article
DE hypercholesterolemia; red yeast rice (RYR); bergamot polyphenolic
   fraction (BPF); malondialdehyde (MDA); oxidative stress; proprotein
   convertase subtilisin; kexin type 9 (PCSK9)
ID LDL-CHOLESTEROL; ENDOTHELIAL DYSFUNCTION; CLINICAL-EFFICACY; OXIDATIVE
   STRESS; SAFETY; INFLAMMATION; METAANALYSIS; ASSOCIATION; PREVENTION;
   STATINS
AB Elevated serum cholesterol levels, either associated or not with increased triglycerides, represent a risk of developing vascular injury, mostly leading to atherothrombosis-related diseases including myocardial infarction and stroke. Natural products have been investigated in the last few decades as they are seen to offer an alternative solution to counteract cardiometabolic risk, due to the occurrence of side effects with the use of statins, the leading drugs for treating hyperlipidemias. Red yeast rice (RYR), a monacolin K-rich natural extract, has been found to be effective in counteracting high cholesterol, being its use accompanied by consistent warnings by regulatory authorities based on the potential detrimental responses accompanying its statin-like chemical charcateristics. Here we compared the effects of RYR with those produced by bergamot polyphenolic fraction (BPF), a well-known natural extract proven to be effective in lowering both serum cholesterol and triglycerides in animals fed a hyperlipidemic diet. In particular, BPF at doses of 10 mg/Kg given orally for 30 consecutive days, counteracted the elevation of both serum LDL cholesterol (LDL-C) and triglycerides induced by the hyperlipidemic diet, an effect which was accompanied by significant reductions of malondialdehyde (MDA) and glutathione peroxidase serum levels, two biomarkers of oxidative stress. Furthermore, the activity of BPF was associated to increased HDL cholesterol (HDL-C) levels and to strong reduction of Proprotein convertase subtilisin/kexin type 9 (PCSK9) levels which were found increased in hyperlipidemic rats. In contrast, RYR at doses of 1 and 3 mg/Kg, produced only significant reduction of LDL-C with very poor effects on triglycerides, HDL-C, glutathione peroxidase, MDA and PCSK9 expression. This indicates that while BPF and RYR both produce serum cholesterol-lowering benefits, BPF produces additional effects on triglycerides and HDL cholesterol compared to RYR at the doses used throughout the study. These additional effects of BPF appear to be related to the reduction of PCSK9 expression and to the antioxidant properties of this extract compared to RYR, thereby suggesting a more complete protection from cardiometabolic risk.
C1 [Mollace, Rocco; Macri, Roberta; Tavernese, Annamaria; Gliozzi, Micaela; Musolino, Vincenzo; Carresi, Cristina; Maiuolo, Jessica; Fini, Massimo; Volterrani, Maurizio; Mollace, Vincenzo] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Inst Res Food Safety & Hlth IRC FSH, I-88100 Catanzaro, Italy.
   [Mollace, Rocco; Fini, Massimo; Volterrani, Maurizio; Mollace, Vincenzo] IRCCS San Raffaele Pisana, Via Valcannuta, I-88163 Rome, Italy.
C3 Magna Graecia University of Catanzaro; IRCCS San Raffaele Pisana
RP Mollace, V (corresponding author), Magna Graecia Univ Catanzaro, Dept Hlth Sci, Inst Res Food Safety & Hlth IRC FSH, I-88100 Catanzaro, Italy.; Mollace, V (corresponding author), IRCCS San Raffaele Pisana, Via Valcannuta, I-88163 Rome, Italy.
EM rocco.mollace@gmail.com; robertamacri85@gmail.com;
   an.tavernese@gmail.com; micaela.gliozzi@gmail.com; xabaras3@hotmail.com;
   carresi@unicz.it; jessicamaiuolo@virgilio.it;
   massimo.fini@sanraffaele.it; maurizio.volterrani@sanraffaele.it;
   mollace@libero.it
RI MACRI', Roberta/AAC-5967-2022; Musolino, Vincenzo/AAC-6429-2022;
   Maiuolo, Jessica/AAU-2482-2020; Gliozzi, Micaela/D-4405-2015; carresi,
   cristina/AAC-6354-2022; Mollace, Rocco/ABH-5643-2020; volterrani,
   maurizio/K-5919-2016
OI Mollace, Rocco/0000-0002-7106-5595; volterrani,
   maurizio/0000-0002-2624-9213; MACRI', Roberta/0000-0002-2345-6751;
   Musolino, Vincenzo/0000-0002-4763-2211; tavernese,
   annamaria/0000-0002-2940-3482; mollace, vincenzo/0000-0002-0392-7173
FU Italian Ministry of Research [PON-MIUR 03PE000_78_1, PON-MIUR
   03PE000_78_2]
FX The work was supported by the public resources from the Italian Ministry
   of Research: PON-MIUR 03PE000_78_1 and PONMIUR 03PE000_78_2. POR
   Calabria FESR FSE 2014-2020 Asse 12-Azioni 10.5.6 e 10.5.12.
CR [Anonymous], 1986, Official Journal L, V358, P0001
   Baigent C, 2010, LANCET, V376, P1670, DOI 10.1016/S0140-6736(10)61350-5
   Burke FM, 2015, CURR ATHEROSCLER REP, V17, DOI 10.1007/s11883-015-0495-8
   Cammisotto V, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9040296
   Carrier B, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0090863
   Castilla-Guerra L, 2016, CURR PHARM DESIGN, V22, P4638, DOI 10.2174/1381612822666160510125229
   Cicero Arrigo F G, 2019, Methodist Debakey Cardiovasc J, V15, P192, DOI 10.14797/mdcj-15-3-192
   Di Donna L, 2009, J NAT PROD, V72, P1352, DOI 10.1021/np900096w
   Dounousi E, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/6677012
   Drexel H, 2020, EUR HEART J-CARD PHA, V6, P115, DOI 10.1093/ehjcvp/pvz079
   Gencer B, 2020, LANCET, V396, P1637, DOI 10.1016/S0140-6736(20)32332-1
   German CA, 2020, BIODRUGS, V34, P1, DOI 10.1007/s40259-019-00399-6
   Giugliano RP, 2017, LANCET, V390, P1962, DOI 10.1016/S0140-6736(17)32290-0
   Gliozzi M, 2021, PHARMACOL RES, V163, DOI 10.1016/j.phrs.2020.105215
   Gliozzi M, 2013, INT J CARDIOL, V170, P140, DOI 10.1016/j.ijcard.2013.08.125
   Lahera V, 2007, CURR MED CHEM, V14, P243, DOI 10.2174/092986707779313381
   Lammi C, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9090798
   Lin YK, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10081280
   Melendez QM, 2017, ARCH BIOCHEM BIOPHYS, V625, P39, DOI 10.1016/j.abb.2017.06.001
   Michos ED, 2019, NEW ENGL J MED, V381, P1557, DOI 10.1056/NEJMra1806939
   Mollace V, 2019, ENDOCR METAB IMMUNE, V19, P136, DOI 10.2174/1871530319666181203151513
   Mollace V, 2011, FITOTERAPIA, V82, P309, DOI 10.1016/j.fitote.2010.10.014
   Morelli MB, 2019, ATHEROSCLEROSIS, V289, P176, DOI 10.1016/j.atherosclerosis.2019.07.023
   Musolino V, 2017, J BIOL REG HOMEOS AG, V31, P1087
   Musolino V, 2020, J TRADIT COMPL MED, V10, P268, DOI 10.1016/j.jtcme.2020.02.004
   Musolino V, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-59485-3
   Musolino V, 2019, LIPIDS HEALTH DIS, V18, DOI 10.1186/s12944-019-1061-0
   Nguyen T, 2017, FOODS, V6, DOI 10.3390/foods6030019
   Nissen SE, 2016, JAMA-J AM MED ASSOC, V315, P1580, DOI 10.1001/jama.2016.3608
   Pirillo A, 2015, ATHEROSCLEROSIS, V243, P449, DOI 10.1016/j.atherosclerosis.2015.09.032
   Pisciotta L, 2007, ATHEROSCLEROSIS, V194, pE116, DOI 10.1016/j.atherosclerosis.2006.10.036
   Pohjola-Sintonen Sinikka, 2014, Duodecim, V130, P1622
   Rosenson RS, 2018, J AM COLL CARDIOL, V72, P314, DOI 10.1016/j.jacc.2018.04.054
   Sakamoto K, 2013, J PHARMACOL SCI, V123, P289, DOI 10.1254/jphs.13R06CP
   Santulli G, 2021, EUR HEART J-CARD PHA, V7, pE11, DOI 10.1093/ehjcvp/pvab014
   Seidah NG, 2014, CIRC RES, V114, P1022, DOI 10.1161/CIRCRESAHA.114.301621
   Silverman MG, 2016, JAMA-J AM MED ASSOC, V316, P1289, DOI 10.1001/jama.2016.13985
   Sirtori CR, 2014, PHARMACOL RES, V88, P3, DOI 10.1016/j.phrs.2014.03.002
   Taylor BA, 2016, CURR ATHEROSCLER REP, V18, DOI 10.1007/s11883-016-0604-3
   Tomaszewski M, 2011, PHARMACOL REP, V63, P859, DOI 10.1016/S1734-1140(11)70601-6
   Trinder M, 2020, JAMA CARDIOL, V5, P390, DOI 10.1001/jamacardio.2019.5954
   Wang DD, 2020, J BIOL CHEM, V295, P15870, DOI 10.1074/jbc.RA120.015623
   Wang TJ, 2019, AM J CHINESE MED, V47, P323, DOI 10.1142/S0192415X19500150
   Ward NC, 2019, CIRC RES, V124, P328, DOI 10.1161/CIRCRESAHA.118.312782
   Younes M, 2018, EFSA J, V16, DOI 10.2903/j.efsa.2018.5368
NR 45
TC 14
Z9 14
U1 0
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2022
VL 14
IS 3
AR 477
DI 10.3390/nu14030477
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ZC3OL
UT WOS:000757433400001
PM 35276836
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wolf, EJ
   Morrison, FG
AF Wolf, Erika J.
   Morrison, Filomene G.
TI Traumatic Stress and Accelerated Cellular Aging: From Epigenetics to
   Cardiometabolic Disease
SO CURRENT PSYCHIATRY REPORTS
LA English
DT Review
DE Traumatic stress; PTSD; Accelerated aging; Epigenetic clock;
   Inflamm-aging; Immunosenescence
ID LEUKOCYTE TELOMERE LENGTH; DNA METHYLATION AGE; ALL-CAUSE MORTALITY;
   METABOLIC SYNDROME; DISORDER SYMPTOMS; OXIDATIVE STRESS;
   PSYCHIATRIC-DISORDERS; ALZHEIMERS-DISEASE; CORTICAL THICKNESS; CLOCK
   ANALYSIS
AB Purpose of Review The aim of this paper is to review the recent literature on traumatic stress-related accelerated aging, including a focus on cellular mechanisms and biomarkers of cellular aging and on the clinical manifestations of accelerated biological aging.
   Recent Findings Multiple lines of research converge to suggest that PTSD is associated with accelerated aging in the epigenome, and the immune and inflammation systems, and this may be reflected in premature onset of cardiometabolic and cardiovascular disease.
   Summary The current state of research paves the way for future work focused on identifying the peripheral and central biological mechanisms linking traumatic stress to accelerated biological aging and medical morbidity, with an emphasis on processes involved in inflammation, immune functioning, oxidative stress, autonomic arousal, and stress response. Ultimately, such work could help reduce the pace of biological aging and improve health and wellness.
C1 [Wolf, Erika J.] VA Boston Healthcare Syst, Natl Ctr PTSD, 116B-2,150 South Huntington Ave, Boston, MA 02130 USA.
   [Wolf, Erika J.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA.
   [Morrison, Filomene G.] Harvard Med Sch, McLean Hosp, Belmont, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; Boston University; Harvard University; Harvard
   University Medical Affiliates; McLean Hospital
RP Wolf, EJ (corresponding author), VA Boston Healthcare Syst, Natl Ctr PTSD, 116B-2,150 South Huntington Ave, Boston, MA 02130 USA.; Wolf, EJ (corresponding author), Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA.
EM erika.wolf@va.gov
OI Wolf, Erika/0000-0003-2666-2435
FU National Institute on Aging of the National Institutes of Health
   [R03AG051877]; Merit Review Award from the US Department of Veterans
   Affairs (VA) Clinical Sciences Research and Development (CSRD) Service
   [I01 CX-001276-01]; Presidential Early Career Award for Scientists and
   Engineers [PECASE 2013A]
FX This work was supported in part by the National Institute on Aging of
   the National Institutes of Health award R03AG051877 to EJW and by Merit
   Review Award Number I01 CX-001276-01 to EJW from the US Department of
   Veterans Affairs (VA) Clinical Sciences Research and Development (CSRD)
   Service. This work was also supported by a Presidential Early Career
   Award for Scientists and Engineers (PECASE 2013A) to EJW as administered
   by the US Department of VA Office of Research and Development.
CR Aiello AE, 2016, PSYCHONEUROENDOCRINO, V67, P133, DOI 10.1016/j.psyneuen.2016.01.024
   [Anonymous], PSYCHOL MED
   Arenson M, 2017, PTSD RES Q, V28, P1
   Barrett JH, 2015, HUM GENET, V134, P679, DOI 10.1007/s00439-015-1563-4
   Bartoli F, 2013, METAB SYNDR RELAT D, V11, P301, DOI 10.1089/met.2013.0010
   Baylis D, 2013, AGE, V35, P963, DOI 10.1007/s11357-012-9396-8
   Beristianos MH, 2016, AM J GERIAT PSYCHIAT, V24, P192, DOI 10.1016/j.jagp.2014.12.003
   Bersani FS, 2016, J AFFECT DISORDERS, V190, P537, DOI 10.1016/j.jad.2015.10.037
   Binder EB, 2008, JAMA-J AM MED ASSOC, V299, P1291, DOI 10.1001/jama.299.11.1291
   Blessing EM, 2017, PSYCHONEUROENDOCRINO, V82, P91, DOI 10.1016/j.psyneuen.2017.04.016
   Boks MP, 2016, NEUROPSYCHOPHARMACOL, V41, P1350, DOI 10.1038/npp.2015.286
   Boks MP, 2015, PSYCHONEUROENDOCRINO, V51, P506, DOI 10.1016/j.psyneuen.2014.07.011
   Breen MS, 2015, MOL PSYCHIATR, V20, P1538, DOI 10.1038/mp.2015.9
   Campisi J, 2007, NAT REV MOL CELL BIO, V8, P729, DOI 10.1038/nrm2233
   Cannizzo ES, 2011, J PROTEOMICS, V74, P2313, DOI 10.1016/j.jprot.2011.06.005
   Chen BH, 2016, AGING-US, V8, P1844, DOI 10.18632/aging.101020
   Christensen BC, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000602
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Da CostaJ.M., 1871, AM J MED SCI, V61, P17
   Darrow SM, 2016, PSYCHOSOM MED, V78, P776, DOI 10.1097/PSY.0000000000000356
   Dedert EA, 2010, ANN BEHAV MED, V39, P61, DOI 10.1007/s12160-010-9165-9
   Dennis PA, 2017, PSYCHOSOM MED, V79, P496, DOI 10.1097/PSY.0000000000000438
   Durso DF, 2017, ONCOTARGET, V8, P23237, DOI 10.18632/oncotarget.15573
   Edmondson D, 2013, AM HEART J, V166, P806, DOI 10.1016/j.ahj.2013.07.031
   Edmondson D, 2013, PROG CARDIOVASC DIS, V55, P548, DOI 10.1016/j.pcad.2013.03.004
   Epel ES, 2009, HORM-INT J ENDOCRINO, V8, P7, DOI 10.14310/horm.2002.1217
   Epel ES, 2004, P NATL ACAD SCI USA, V101, P17312, DOI 10.1073/pnas.0407162101
   Fougère B, 2017, J GERONTOL A-BIOL, V72, P1218, DOI 10.1093/gerona/glw240
   Franceschi C, 2000, EXP GERONTOL, V35, P879, DOI 10.1016/S0531-5565(00)00172-8
   Fülöp T, 2016, REV INVEST CLIN, V68, P84
   Gradus JL, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2015-009334
   Green E, 2016, GERONTOLOGIST, V56, P72, DOI 10.1093/geront/gnv040
   Grenon SM, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.115.003010
   Hannum G, 2013, MOL CELL, V49, P359, DOI 10.1016/j.molcel.2012.10.016
   Horvath S, 2016, GENOME BIOL, V17, DOI 10.1186/s13059-016-1030-0
   Horvath S, 2015, AGING-US, V7, P1130, DOI 10.18632/aging.100859
   Horvath S, 2013, GENOME BIOL, V14, DOI 10.1186/gb-2013-14-10-r115
   Huh CJ, 2016, ELIFE, V5, DOI [10.7554/elife.18648, 10.7554/eLife.18648]
   Hurtado-Alvarado G, 2016, PLOS ONE, V11
   Klengel T, 2013, NAT NEUROSCI, V16, P33, DOI 10.1038/nn.3275
   Koenen KC, 2017, PSYCHOL MED, V47, P209, DOI [10.1017/s0033291716002294, 10.1017/S0033291716002294]
   Lavagnino L, 2016, NEUROSCI BIOBEHAV R, V68, P714, DOI 10.1016/j.neubiorev.2016.06.041
   Levine AJ, 2016, J NEUROVIROL, V22, P366, DOI 10.1007/s13365-015-0406-3
   Levine AB, 2014, CARDIOLOGY, V127, P1, DOI 10.1159/000354910
   Levine ME, 2015, AGING-US, V7, P1198, DOI 10.18632/aging.100864
   Lindemer ER, 2013, NEUROIMAGE-CLIN, V2, P601, DOI 10.1016/j.nicl.2013.04.009
   Lindqvist D, 2015, NEUROSCI BIOBEHAV R, V55, P333, DOI 10.1016/j.neubiorev.2015.05.007
   Liu XS, 2016, CELL, V167, P233, DOI 10.1016/j.cell.2016.08.056
   Logue MW, 2013, MOL PSYCHIATR, V18, P937, DOI 10.1038/mp.2012.113
   Lowe D, 2016, ONCOTARGET, V7, P8524, DOI 10.18632/oncotarget.7383
   Lu AT, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms15353
   Macaulay R, 2013, AGE, V35, P563, DOI 10.1007/s11357-012-9381-2
   Mackenzie J, 1916, BRIT MED J, V1916, P117, DOI 10.1136/bmj.1.2873.117
   Macosko EZ, 2015, CELL, V161, P1202, DOI 10.1016/j.cell.2015.05.002
   Marioni RE, 2015, GENOME BIOL, V16, DOI 10.1186/s13059-015-0584-6
   Mathur MB, 2016, BRAIN BEHAV IMMUN, V54, P158, DOI 10.1016/j.bbi.2016.02.002
   Mauro C, 2015, FRONT IMMUNOL, V5, P1, DOI 10.3389/fimmu.2014.00677
   Mehta D, 2012, NEUROPHARMACOLOGY, V62, P654, DOI 10.1016/j.neuropharm.2011.03.009
   Miller MW, 2014, MOL PSYCHIATR, V19, P1156, DOI 10.1038/mp.2014.111
   Miller MW, 2015, PSYCHONEUROENDOCRINO, V62, P359, DOI 10.1016/j.psyneuen.2015.09.003
   Miller MW, 2017, HARV REV PS IN PRESS
   Mohlenhoff BS, 2017, CURR PSYCHI IN PRESS
   Müezzinler A, 2013, AGEING RES REV, V12, P509, DOI 10.1016/j.arr.2013.01.003
   Nalecz Katarzyna A., 2004, Molecular Aspects of Medicine, V25, P551
   O'Donovan A, 2017, BRAIN BEHAV IMMUN, V60, P198, DOI 10.1016/j.bbi.2016.10.014
   O'Donovan A, 2015, BIOL PSYCHIAT, V77, P365, DOI 10.1016/j.biopsych.2014.06.015
   Orr AG, 2015, NAT NEUROSCI, V18, P423, DOI 10.1038/nn.3930
   Passos IC, 2015, LANCET PSYCHIAT, V2, P1002, DOI 10.1016/S2215-0366(15)00309-0
   Pawelec G, 2006, EXP GERONTOL, V41, P1239, DOI 10.1016/j.exger.2006.09.005
   Perna L, 2016, CLIN EPIGENETICS, V8, DOI 10.1186/s13148-016-0228-z
   Pettegrew JW, 2000, MOL PSYCHIATR, V5, P616, DOI 10.1038/sj.mp.4000805
   Pollard HB, 2016, FRONT MOL NEUROSCI, V9, DOI 10.3389/fnmol.2016.00087
   Quach A, 2017, AGING-US, V9, P419, DOI 10.18632/aging.101168
   Ratanatharathorn A, 2017, AM J MED GENET B
   Reddy TP, 2011, INT J ENV RES PUB HE, V8, P203, DOI 10.3390/ijerph8010203
   Ribas GS, 2014, GENE, V533, P469, DOI 10.1016/j.gene.2013.10.017
   Roberts AL, 2017, DEPRESS ANXIETY, V34, P391, DOI 10.1002/da.22620
   Rosen RL, 2017, J PSYCHIATR RES, V89, P14, DOI 10.1016/j.jpsychires.2017.01.007
   Rosenbaum S, 2015, METABOLISM, V64, P926, DOI [10.1016/j.metabol.2015.04.009, 10.1016/j.metabol.2015.01.016]
   Roy SS, 2015, AM J PUBLIC HEALTH, V105, P757, DOI 10.2105/AJPH.2014.302342
   Rudolf RD, 1916, CAN MED ASSOC J, V6, P796
   Sadeh N, 2016, DEPRESS ANXIETY, V33, P308, DOI 10.1002/da.22480
   Sitta A, 2011, CELL MOL NEUROBIOL, V31, P429, DOI 10.1007/s10571-010-9636-3
   Soliman MA, 2017, MOL PSYCHIATR, V22, P1241, DOI 10.1038/mp.2017.40
   Sommershof A, 2009, BRAIN BEHAV IMMUN, V23, P1117, DOI 10.1016/j.bbi.2009.07.003
   Song SW, 2015, BRAIN IMAGING BEHAV, V9, P588, DOI 10.1007/s11682-014-9311-2
   Stubbs TM, 2017, GENOME BIOL, V18, DOI 10.1186/s13059-017-1203-5
   Sumner JA, 2016, PSYCHOL MED, V46, P3105, DOI 10.1017/S0033291716001914
   Sumner JA, 2017, BIOL PSYCHI IN PRESS
   Sumner JA, 2017, DEPRESS ANXIETY, V34, P356, DOI 10.1002/da.22600
   Sumner JA, 2015, CIRCULATION, V132, P251, DOI 10.1161/CIRCULATIONAHA.114.014492
   Taylor-Clift A, 2016, J AFFECT DISORDERS, V190, P227, DOI 10.1016/j.jad.2015.09.023
   Vaccarino V, 2013, J AM COLL CARDIOL, V62, P970, DOI 10.1016/j.jacc.2013.04.085
   Wagner W, 2017, GENOME BIOL, V18, DOI 10.1186/s13059-017-1245-8
   Wikby A, 2005, J GERONTOL A-BIOL, V60, P556, DOI 10.1093/gerona/60.5.556
   Williamson JB, 2015, FRONT PSYCHOL, V5, DOI 10.3389/fpsyg.2014.01571
   Wolf EJ, 2016, PSYCHOL MED, V46, P2215, DOI 10.1017/S0033291716000817
   Wolf EJ, 2017, TRAUMATIC S IN PRESS
   Wolf EJ, 2017, PSYCHOSOM M IN PRESS
   Wolf EJ, 2017, BRAIN BEHAV IMMUN, V65, P328, DOI 10.1016/j.bbi.2017.06.001
   Wolf EJ, 2016, PSYCHIAT ANN, V46, P527, DOI 10.3928/00485713-20160729-01
   Wolf EJ, 2016, BIOL PSYCHIAT, V80, P363, DOI 10.1016/j.biopsych.2015.11.023
   Wolf EJ, 2016, PSYCHONEUROENDOCRINO, V63, P155, DOI 10.1016/j.psyneuen.2015.09.020
   Yaffe K, 2010, ARCH GEN PSYCHIAT, V67, P608, DOI 10.1001/archgenpsychiatry.2010.61
   Yang RT, 2013, BMC SYST BIOL, V7, DOI 10.1186/1752-0509-7-80
   Zannas AS, 2015, GENOME BIOL, V16, DOI 10.1186/s13059-015-0828-5
NR 106
TC 59
Z9 61
U1 2
U2 28
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1523-3812
EI 1535-1645
J9 CURR PSYCHIAT REP
JI Curr. Psychiatry Rep.
PD OCT
PY 2017
VL 19
IS 10
AR 75
DI 10.1007/s11920-017-0823-5
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FH4WJ
UT WOS:000411162700010
PM 28852965
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Tyagi, A
   Pugazhenthi, S
AF Tyagi, Alpna
   Pugazhenthi, Subbiah
TI A Promising Strategy to Treat Neurodegenerative Diseases by SIRT3
   Activation
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE SIRT3; longevity; mitochondria; metabolism; oxidative stress;
   neurodegeneration; metabolic syndrome; Alzheimer's disease
ID INSULIN-DEGRADING ENZYME; MITOCHONDRIAL SIRT3; ALZHEIMERS-DISEASE;
   SKELETAL-MUSCLE; CALORIE RESTRICTION; OXIDATIVE STRESS; COGNITIVE
   IMPAIRMENT; ENERGY-METABOLISM; DEACETYLASE SIRT3; PROTECTS
AB SIRT3, the primary mitochondrial deacetylase, regulates the functions of mitochondrial proteins including metabolic enzymes and respiratory chain components. Although SIRT3's functions in peripheral tissues are well established, the significance of its downregulation in neurodegenerative diseases is beginning to emerge. SIRT3 plays a key role in brain energy metabolism and provides substrate flexibility to neurons. It also facilitates metabolic coupling between fuel substrate-producing tissues and fuel-consuming tissues. SIRT3 mediates the health benefits of lifestyle-based modifications such as calorie restriction and exercise. SIRT3 deficiency is associated with metabolic syndrome (MetS), a precondition for diseases including obesity, diabetes, and cardiovascular disease. The pure form of Alzheimer's disease (AD) is rare, and it has been reported to coexist with these diseases in aging populations. SIRT3 downregulation leads to mitochondrial dysfunction, neuroinflammation, and inflammation, potentially triggering factors of AD pathogenesis. Recent studies have also suggested that SIRT3 may act through multiple pathways to reduce plaque formation in the AD brain. In this review, we give an overview of SIRT3's roles in brain physiology and pathology and discuss several activators of SIRT3 that can be considered potential therapeutic agents for the treatment of dementia.
C1 [Tyagi, Alpna; Pugazhenthi, Subbiah] Rocky Mt Reg VA Med Ctr, Aurora, CO 80045 USA.
   [Tyagi, Alpna; Pugazhenthi, Subbiah] Univ Colorado Anschutz Med Campus, Dept Med, Aurora, CO 80045 USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus
RP Pugazhenthi, S (corresponding author), Rocky Mt Reg VA Med Ctr, Aurora, CO 80045 USA.; Pugazhenthi, S (corresponding author), Univ Colorado Anschutz Med Campus, Dept Med, Aurora, CO 80045 USA.
EM subbiah.pugazhenthi@cuanschutz.edu
FU Veterans Administration [NURD-016-18F BX004480]
FX This study was supported by a Merit Review grant NURD-016-18F BX004480
   from the Veterans Administration (to S.P.).
CR Ahn BH, 2008, P NATL ACAD SCI USA, V105, P14447, DOI 10.1073/pnas.0803790105
   Akhmedov A, 2020, THROMB HAEMOSTASIS, V120, P168, DOI 10.1055/s-0039-3400299
   Albani D, 2014, AGE, V36, P469, DOI 10.1007/s11357-013-9559-2
   Bagul PK, 2018, CELLS-BASEL, V7, DOI 10.3390/cells7120235
   Bao JJ, 2010, FREE RADICAL BIO MED, V49, P1230, DOI 10.1016/j.freeradbiomed.2010.07.009
   Barger JL, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0120738
   Benigni A, 2019, ANTIOXID REDOX SIGN, V31, P1255, DOI 10.1089/ars.2018.7703
   BERG BN, 1960, J NUTR, V71, P255
   Bernal-Ramírez J, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/9912434
   Bharathi SS, 2013, J BIOL CHEM, V288, P33837, DOI 10.1074/jbc.M113.510354
   Boyle KE, 2013, J CLIN ENDOCR METAB, V98, pE1601, DOI 10.1210/jc.2013-1943
   Brandauer J, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00085
   Brown K, 2013, CELL REP, V3, P319, DOI 10.1016/j.celrep.2013.01.005
   Brown KD, 2014, CELL METAB, V20, P1059, DOI 10.1016/j.cmet.2014.11.003
   Bugga P, 2022, CELL SIGNAL, V94, DOI 10.1016/j.cellsig.2022.110309
   Camacho-Pereira J, 2016, CELL METAB, V23, P1127, DOI 10.1016/j.cmet.2016.05.006
   Chen MT, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201800612
   Chen T, 2021, CNS NEUROSCI THER, V27, P134, DOI 10.1111/cns.13580
   Chen TS, 2021, LIFE SCI, V264, DOI 10.1016/j.lfs.2020.118724
   Chen TS, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0118909
   Cheng AW, 2020, J NEUROSCI, V40, P694, DOI 10.1523/JNEUROSCI.1446-19.2019
   Cheng AW, 2016, CELL METAB, V23, P128, DOI 10.1016/j.cmet.2015.10.013
   Cimen H, 2010, BIOCHEMISTRY-US, V49, P304, DOI 10.1021/bi901627u
   Conze D, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-46120-z
   Cooper HM, 2008, BIOCHEM J, V411, P279, DOI 10.1042/BJ20071624
   Corpas R, 2019, FRONT AGING NEUROSCI, V11, DOI 10.3389/fnagi.2019.00352
   Cui XX, 2017, BIOCHEM BIOPH RES CO, V484, P767, DOI 10.1016/j.bbrc.2017.01.163
   Cunnane S, 2011, NUTRITION, V27, P3, DOI 10.1016/j.nut.2010.07.021
   Dai SH, 2014, INT J MOL SCI, V15, P14591, DOI 10.3390/ijms150814591
   Dai SH, 2022, J NEUROINFLAMM, V19, DOI 10.1186/s12974-022-02474-2
   Denu RA, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/5841716
   Diao ZQ, 2021, NUCLEIC ACIDS RES, V49, P4203, DOI 10.1093/nar/gkab161
   Dikalov S, 2022, CURR OPIN NEPHROL HY, V31, P151, DOI 10.1097/MNH.0000000000000771
   Dittenhafer-Reed KE, 2015, CELL METAB, V21, P637, DOI 10.1016/j.cmet.2015.03.007
   Du YY, 2017, GENE, V626, P182, DOI 10.1016/j.gene.2017.05.018
   Duan WJ, 2020, PHYTOMEDICINE, V77, DOI 10.1016/j.phymed.2020.153281
   Fontana L, 2015, CELL, V161, P106, DOI 10.1016/j.cell.2015.02.020
   Fu JR, 2012, J BIOL CHEM, V287, P24460, DOI 10.1074/jbc.M112.382226
   Gao JM, 2022, ACTA PHARMACOL SIN, V43, P2482, DOI 10.1038/s41401-022-00888-5
   Gao P, 2022, CIRCULATION, V145, P375, DOI 10.1161/CIRCULATIONAHA.121.055600
   Gelber RP, 2013, NEUROLOGY, V81, P888, DOI 10.1212/WNL.0b013e3182a351d4
   Gelber RP, 2012, CURR ALZHEIMER RES, V9, P664
   Gong B, 2013, NEUROBIOL AGING, V34, P1581, DOI 10.1016/j.neurobiolaging.2012.12.005
   Govindarajulu M, 2021, NEUROCHEM INT, V144, DOI 10.1016/j.neuint.2021.104958
   Guo XB, 2020, J CARDIOVASC PHARM, V76, P296, DOI 10.1097/FJC.0000000000000877
   Guo YY, 2021, REDOX BIOL, V41, DOI 10.1016/j.redox.2021.101915
   Gurung P, 2015, TRENDS MOL MED, V21, P193, DOI 10.1016/j.molmed.2014.11.008
   Hallows William C, 2008, Biochem J, V411, pe11, DOI 10.1042/BJ20080336
   Hallows WC, 2011, MOL CELL, V41, P139, DOI 10.1016/j.molcel.2011.01.002
   Han C, 2013, EXP GERONTOL, V48, P1091, DOI 10.1016/j.exger.2013.02.014
   Han L, 2020, FOOD FUNCT, V11, P3073, DOI [10.1039/c9fo02334h, 10.1039/C9FO02334H]
   Han PC, 2014, NEUROBIOL AGING, V35, P2064, DOI 10.1016/j.neurobiolaging.2014.03.022
   Han WM, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.607796
   He XC, 2019, J CELL PHYSIOL, V234, P2252, DOI 10.1002/jcp.27200
   He XC, 2017, J MOL CELL CARDIOL, V112, P104, DOI 10.1016/j.yjmcc.2017.09.007
   Hebert AS, 2013, MOL CELL, V49, P186, DOI 10.1016/j.molcel.2012.10.024
   Heneka MT, 2015, LANCET NEUROL, V14, P388, DOI 10.1016/S1474-4422(15)70016-5
   Hickman SE, 2013, NAT NEUROSCI, V16, P1896, DOI 10.1038/nn.3554
   Hirschey MD, 2011, MOL CELL, V44, P177, DOI 10.1016/j.molcel.2011.07.019
   Hirschey MD, 2009, METHOD ENZYMOL, V457, P137, DOI 10.1016/S0076-6879(09)05008-3
   Hor JH, 2021, CELL DEATH DIFFER, V28, P1379, DOI 10.1038/s41418-020-00664-0
   Hu JG, 2022, J TRANSL MED, V20, DOI 10.1186/s12967-022-03642-x
   Huang L, 2022, EXP EYE RES, V218, DOI 10.1016/j.exer.2022.109015
   Huang W, 2016, BIOMED RES INT, V2016, DOI 10.1155/2016/8263926
   Iwahara T, 2012, MOL CELL BIOL, V32, P5022, DOI 10.1128/MCB.00822-12
   Jiang DQ, 2022, EXP THER MED, V24, DOI 10.3892/etm.2022.11598
   Jiang DQ, 2019, J NEURAL TRANSM, V126, P559, DOI 10.1007/s00702-019-02005-z
   Jiang DQ, 2017, FRONT CELL NEUROSCI, V11, DOI 10.3389/fncel.2017.00007
   Jin L, 2009, PROTEIN SCI, V18, P514, DOI 10.1002/pro.50
   Jing EX, 2013, DIABETES, V62, P3404, DOI 10.2337/db12-1650
   Jing EX, 2011, P NATL ACAD SCI USA, V108, P14608, DOI 10.1073/pnas.1111308108
   Kaeberlein M, 1999, GENE DEV, V13, P2570, DOI 10.1101/gad.13.19.2570
   Kalsbeek MJT, 2016, MOL CELL ENDOCRINOL, V438, P27, DOI 10.1016/j.mce.2016.09.028
   Kawas CH, 2015, NEUROLOGY, V85, P535, DOI 10.1212/WNL.0000000000001831
   Kendrick AA, 2011, BIOCHEM J, V433, P505, DOI 10.1042/BJ20100791
   Kim SH, 2011, PLOS ONE, V6, DOI [10.1371/journal.pone.0014731, 10.1371/journal.pone.0026214]
   Klimova N, 2020, EXP NEUROL, V325, DOI 10.1016/j.expneurol.2019.113144
   Koentges C, 2015, BASIC RES CARDIOL, V110, DOI 10.1007/s00395-015-0493-6
   Kurauti MA, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0160239
   Kwon S, 2017, J BIOL CHEM, V292, P17312, DOI 10.1074/jbc.M117.778720
   Lantier L, 2015, DIABETES, V64, P3081, DOI 10.2337/db14-1810
   Leal MC, 2013, J BIOL CHEM, V288, P12920, DOI 10.1074/jbc.M112.424820
   Lee J, 2018, AGING CELL, V17, DOI 10.1111/acel.12679
   Lee S, 2021, EXP NEUROBIOL, V30, P341, DOI 10.5607/en21021
   Li C, 2021, J CELL MOL MED, V25, P323, DOI 10.1111/jcmm.16052
   Li HT, 2018, J ALZHEIMERS DIS, V64, P291, DOI 10.3233/JAD-180126
   Li XH, 2018, TISSUE CELL, V52, P1, DOI 10.1016/j.tice.2018.03.004
   Li Y, 2021, PHYTOTHER RES, V35, P4579, DOI 10.1002/ptr.7175
   Liao GX, 2020, J INT MED RES, V48, DOI 10.1177/0300060520963993
   Liu DW, 2022, PHYTOMEDICINE, V101, DOI 10.1016/j.phymed.2022.154098
   Liu GD, 2015, INT J CLIN EXP PATHO, V8, P353
   Liu JX, 2018, EUR J PHARMACOL, V834, P176, DOI 10.1016/j.ejphar.2018.07.036
   Liu JX, 2021, CHIN MED-UK, V16, DOI 10.1186/s13020-021-00528-w
   Liu L, 2021, AGING-US, V13, P16105, DOI 10.18632/aging.203137
   Liu M, 2021, NEUROCHEM RES, V46, P3166, DOI 10.1007/s11064-021-03414-x
   Liu P, 2016, MOL NEUROBIOL, V53, P7200, DOI 10.1007/s12035-015-9627-y
   Liu Y, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-09897-1
   Magistretti PJ, 2015, NEURON, V86, P883, DOI 10.1016/j.neuron.2015.03.035
   Magnifico S, 2013, FASEB J, V27, P4712, DOI 10.1096/fj.13-229781
   Martens CR, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-03421-7
   Mhatre SD, 2015, TRENDS NEUROSCI, V38, P621, DOI 10.1016/j.tins.2015.08.006
   Michan S, 2007, BIOCHEM J, V404, P1, DOI 10.1042/BJ20070140
   Montine TJ, 2012, CURR ALZHEIMER RES, V9, P718
   Morris JK, 2014, BBA-MOL BASIS DIS, V1842, P1340, DOI 10.1016/j.bbadis.2014.04.012
   Mukherjee S, 2021, JCI INSIGHT, V6, DOI 10.1172/jci.insight.147193
   Nahálková J, 2022, BIOCHEMISTRY-MOSCOW+, V87, P21, DOI [10.1134/S0006297922010035, 10.31857/S0320972522020105]
   Naia L, 2021, FREE RADICAL BIO MED, V163, P163, DOI 10.1016/j.freeradbiomed.2020.11.031
   Nakamura Y, 2008, BIOCHEM BIOPH RES CO, V366, P174, DOI 10.1016/j.bbrc.2007.11.122
   Nogueiras R, 2012, PHYSIOL REV, V92, P1479, DOI 10.1152/physrev.00022.2011
   Norden DM, 2013, NEUROPATH APPL NEURO, V39, P19, DOI 10.1111/j.1365-2990.2012.01306.x
   Onyango P, 2002, P NATL ACAD SCI USA, V99, P13653, DOI 10.1073/pnas.222538099
   Osborne B, 2022, BIOCHEM BIOPH RES CO, V607, P131, DOI 10.1016/j.bbrc.2022.03.088
   Osborne TB, 1917, SCIENCE, V45, P294, DOI 10.1126/science.45.1160.294
   Palacios OM, 2009, AGING-US, V1, P771, DOI 10.18632/aging.100075
   Pillai VB, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms7656
   Pinteric M, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22084277
   Qiu CX, 2015, NAT REV CARDIOL, V12, P267, DOI 10.1038/nrcardio.2014.223
   Qiu XL, 2010, CELL METAB, V12, P662, DOI 10.1016/j.cmet.2010.11.015
   Ramesh S, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0190350
   Rardin MJ, 2013, P NATL ACAD SCI USA, V110, P6601, DOI 10.1073/pnas.1302961110
   Rose G, 2003, EXP GERONTOL, V38, P1065, DOI 10.1016/S0531-5565(03)00209-2
   Ruankham W, 2021, NUTR NEUROSCI, V24, P90, DOI 10.1080/1028415X.2019.1596613
   Salamon A, 2020, NEUROCHEM RES, V45, P2072, DOI 10.1007/s11064-020-03069-0
   Scher MB, 2007, GENE DEV, V21, P920, DOI 10.1101/gad.1527307
   Selkoe DJ, 2001, PHYSIOL REV, V81, P741, DOI 10.1152/physrev.2001.81.2.741
   Shen YH, 2020, BIOMED PHARMACOTHER, V132, DOI 10.1016/j.biopha.2020.110928
   Shi H, 2017, HUM MOL GENET, V26, P1915, DOI 10.1093/hmg/ddx100
   Shi T, 2010, J DIGEST DIS, V11, P55, DOI 10.1111/j.1751-2980.2009.00416.x
   Shi ZL, 2018, BIOMED RES INT, V2018, DOI 10.1155/2018/2708491
   Shimazu T, 2010, CELL METAB, V12, P654, DOI 10.1016/j.cmet.2010.11.003
   Sidorova-Darmos E, 2018, FRONT CELL NEUROSCI, V12, DOI 10.3389/fncel.2018.00196
   Sidorova-Darmos E, 2014, FRONT AGING NEUROSCI, V6, DOI 10.3389/fnagi.2014.00333
   Song WJ, 2013, NEUROBIOL DIS, V51, P72, DOI 10.1016/j.nbd.2012.07.004
   Song YF, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23084204
   Sorbara MT, 2011, CELL RES, V21, P558, DOI 10.1038/cr.2011.20
   Su AI, 2004, P NATL ACAD SCI USA, V101, P6062, DOI 10.1073/pnas.0400782101
   Sundaresan NR, 2009, J CLIN INVEST, V119, P2758, DOI 10.1172/JCI39162
   Thangaraj A, 2021, REDOX BIOL, V40, DOI 10.1016/j.redox.2020.101843
   Traba J, 2017, J BIOL CHEM, V292, P12153, DOI 10.1074/jbc.M117.791715
   Traba J, 2017, CELL MOL LIFE SCI, V74, P1777, DOI 10.1007/s00018-016-2431-7
   Tseng AHH, 2013, FREE RADICAL BIO MED, V63, P222, DOI 10.1016/j.freeradbiomed.2013.05.002
   Tyagi A, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-23652-5
   Tyagi A, 2021, FRONT AGING NEUROSCI, V13, DOI 10.3389/fnagi.2021.716616
   Tyagi A, 2020, BBA-MOL BASIS DIS, V1866, DOI 10.1016/j.bbadis.2020.165849
   Tyagi A, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-35890-7
   Tyas SL, 2007, AM J EPIDEMIOL, V165, P1231, DOI 10.1093/aje/kwm085
   Vassilopoulos A, 2014, ANTIOXID REDOX SIGN, V21, P551, DOI 10.1089/ars.2013.5420
   Verdin E, 2015, SCIENCE, V350, P1208, DOI 10.1126/science.aac4854
   Wan RQ, 2022, NEUROCHEM RES, V47, P1012, DOI 10.1007/s11064-021-03502-y
   Wang HN, 2020, MOL MED REP, V22, P1342, DOI 10.3892/mmr.2020.11195
   Wang T, 2022, BIOSCIENCE REP, V42, DOI 10.1042/BSR20211005
   Wang XH, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0018490
   Wang Y, 2021, MOL MED REP, V24, DOI 10.3892/mmr.2021.12273
   Wang YF, 2019, J RECEPT SIG TRANSD, V39, P341, DOI 10.1080/10799893.2019.1684521
   Weir HJM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048225
   White LR, 2016, NEUROLOGY, V86, P1000, DOI 10.1212/WNL.0000000000002480
   Wilkins HM, 2016, CURR TOP MED CHEM, V16, P849, DOI 10.2174/1568026615666150827095102
   Winnik S, 2016, BASIC RES CARDIOL, V111, DOI 10.1007/s00395-016-0552-7
   Woodbury A, 2013, FRONT NEUROL, V4, DOI 10.3389/fneur.2013.00130
   Wu J, 2020, LAB INVEST, V100, P643, DOI 10.1038/s41374-019-0332-8
   Wu WW, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0132499
   Xie LP, 2016, ANTIOXID REDOX SIGN, V24, P329, DOI 10.1089/ars.2015.6331
   Xin RB, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.911716
   Xu SQ, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.625627
   Yan WJ, 2018, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00116
   Yang L, 2016, SCI REP-UK, V6, DOI 10.1038/srep23366
   Yang WX, 2015, NEUROCHEM RES, V40, P1576, DOI 10.1007/s11064-015-1630-1
   Yang X, 2018, CNS NEUROSCI THER, V24, P775, DOI 10.1111/cns.12853
   Yang X, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00943
   Yang YH, 2000, GENOMICS, V69, P355, DOI 10.1006/geno.2000.6360
   Yang YJ, 2010, J BIOL CHEM, V285, P7417, DOI 10.1074/jbc.M109.053421
   Ye JS, 2019, CNS NEUROSCI THER, V25, P355, DOI 10.1111/cns.13053
   Yu W, 2018, MOL MED REP, V18, P4087, DOI 10.3892/mmr.2018.9390
   Yu W, 2012, J BIOL CHEM, V287, P14078, DOI 10.1074/jbc.M112.355206
   Yu WJ, 2017, BBA-MOL BASIS DIS, V1863, P1973, DOI 10.1016/j.bbadis.2016.10.021
   Zeng H, 2016, SCI REP-UK, V6, DOI 10.1038/srep20931
   Zeng H, 2015, J CELL MOL MED, V19, P1847, DOI 10.1111/jcmm.12556
   Zeng LL, 2014, PLOS ONE, V9, DOI [10.1371/journal.pone.0087711, 10.1371/journal.pone.0088019]
   Zhang B, 2013, AGE, V35, P2237, DOI 10.1007/s11357-013-9520-4
   Zhang HB, 2016, SCIENCE, V352, P1436, DOI 10.1126/science.aaf2693
   Zhang JY, 2016, NEUROCHEM RES, V41, P1761, DOI 10.1007/s11064-016-1892-2
   Zhang M, 2018, AGING DIS, V9, P273, DOI 10.14336/AD.2017.0517
   Zhang SH, 2022, REDOX BIOL, V54, DOI 10.1016/j.redox.2022.102390
   Zhang T, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21020372
   Zhang XF, 2016, ANTIOXID REDOX SIGN, V24, P312, DOI 10.1089/ars.2015.6403
   Zhao H, 2018, CELL STRESS CHAPERON, V23, P1079, DOI 10.1007/s12192-018-0917-y
   Zhao ZZ, 2019, BMC NEUROL, V19, DOI 10.1186/s12883-019-1508-y
   Zheng MS, 2022, MOLECULES, V27, DOI 10.3390/molecules27175545
   Zhou L, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11162596
   Zhou X, 2014, CELL DEATH DIS, V5, DOI 10.1038/cddis.2014.530
NR 190
TC 15
Z9 18
U1 3
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2023
VL 24
IS 2
AR 1615
DI 10.3390/ijms24021615
PG 25
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 8C9GO
UT WOS:000917909100001
PM 36675125
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Çevikelli-Yakut, ZA
   Özçelik, R
   Çevik, Ö
   Sener, TE
   Sener, G
AF Cevikelli-Yakut, Zatiye Ayca
   Ozcelik, Reyhan
   Cevik, Ozge
   Sener, Tarik Emre
   Sener, Goksel
TI Exercise and caloric restriction improve cardiovascular and erectile
   function in rats with metabolic syndrome
SO INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
LA English
DT Article
ID ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; ORGAN DAMAGE; NITRIC-OXIDE;
   MELATONIN; PREVENTION; STRESS; MODEL
AB The aim of this study is to examine the possible benefits of exercise and caloric restriction (CR) on cardiovascular hemodynamics, erectile function, and antioxidant system in metabolic syndrome (MS). Sixty male Spraque-Dawley rats were divided into five groups; control, MS, MS + CR, MS + exercise (EXC), and MS + CR + EXC. To induce MS, 10% fructose solution was applied for 3 months. Thereafter, in CR groups calorie was restricted 40% and in EXC groups swimming was performed for 6 weeks. Body weight, blood glucose, and blood pressure (BP) levels were measured before and after MS induction and at the end of the experiment. After decapitation, tumor necrosis factor (TNF)-alpha, adiponectin (ADP), and plasminogen activator inhibitor (PAI)-1 levels were investigated in blood, oxidative stress parameters were examined in heart, aorta, and corpus cavernosum (CC) tissues. Isometric contraction in isolated tissue bath was studied in aorta and CC tissues. Animals subjected to exercise and CR had decreased BP and blood glucose levels. Impaired contraction-relaxation responses in MS group were improved with exercise and CR. MS-induced increase in TNF-alpha, PAI-1, malondialdehyde (MDA), and decrease in ADP, glutathione (GSH), and superoxide dismutase (SOD) were normalized with exercise and CR. Exercise and CR may be beneficial against changes in cardiovascular hemodynamics caused by MS.
C1 [Cevikelli-Yakut, Zatiye Ayca; Ozcelik, Reyhan; Sener, Goksel] Marmara Univ, Sch Pharm, Dept Pharmacol, Istanbul, Turkey.
   [Cevikelli-Yakut, Zatiye Ayca] Trakya Univ, Sch Pharm, Dept Pharmacognosy, Edirne, Turkey.
   [Cevik, Ozge] Adnan Menderes Univ, Sch Med, Dept Biochem, Aydin, Turkey.
   [Sener, Tarik Emre] Marmara Univ, Sch Med, Dept Urol, Istanbul, Turkey.
C3 Marmara University; Trakya University; Adnan Menderes University;
   Marmara University
RP Sener, G (corresponding author), Marmara Univ, Sch Pharm, Dept Pharmacol, Istanbul, Turkey.
EM gsener@marmara.edu.tr
RI Şener, Göksel/AAN-4461-2021; Yakut, Zatiye/AAF-7800-2021; Sener,
   Tarik/K-2501-2016; University, Aydin Adnan/Z-2790-2019
OI Sener, Goksel/0000-0001-7444-6193
FU Marmara University Scientific Research Projects Committee
   [SAG-C-YLP-090113-0002]
FX This study was supported by Marmara University Scientific Research
   Projects Committee with the grant number: SAG-C-YLP-090113-0002.
CR Alzamil H, 2020, J OBES, V2020, DOI 10.1155/2020/5076858
   Bahia Luciana, 2006, Clinics, V61, P433, DOI 10.1590/S1807-59322006000500010
   BEUTLER E, 1963, J LAB CLIN MED, V61, P882
   Bivalacqua TJ, 2007, EUR UROL, V51, P1732, DOI 10.1016/j.eururo.2006.10.061
   Boudreau DM, 2009, METAB SYNDR RELAT D, V7, P305, DOI 10.1089/met.2008.0070
   Buege J A, 1978, Methods Enzymol, V52, P302
   BURNETT AL, 1992, SCIENCE, V257, P401, DOI 10.1126/science.1378650
   Burnett Arthur L, 2006, J Clin Hypertens (Greenwich), V8, P53
   Çakir B, 2010, CELL BIOCHEM FUNCT, V28, P469, DOI 10.1002/cbf.1679
   Cesari M, 2010, CARDIOVASC THER, V28, pe72, DOI 10.1111/j.1755-5922.2010.00171.x
   de Lemos Edite Teixeira, 2007, Med Sci Monit, V13, pBR168
   El Assar M, 2016, J PHYSIOL-LONDON, V594, P3045, DOI 10.1113/JP271836
   El Assar M, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0120479
   Elmas MA, 2019, TISSUE CELL, V57, P57, DOI 10.1016/j.tice.2019.01.005
   García-Prieto CF, 2016, NUTRIENTS, V8, DOI 10.3390/nu8060370
   Gerbild H, 2018, SEX MED-UK, V6, P75, DOI 10.1016/j.esxm.2018.02.001
   Guize L, 2008, ARCH CARDIOVASC DIS, V101, P577, DOI 10.1016/j.acvd.2008.06.011
   Hamilton KL, 2003, FREE RADICAL BIO MED, V34, P800, DOI 10.1016/S0891-5849(02)01431-4
   HATZIMOURATIDIS K., 2016, EAU Guidelines on Erectile Dysfunction, Premature Ejaculation, Penile Curvature and Priapism
   Hermann Matthias, 2006, J Clin Hypertens (Greenwich), V8, P17, DOI 10.1111/j.1524-6175.2006.06032.x
   KRAMER K, 1993, PHYSIOL BEHAV, V53, P271, DOI 10.1016/0031-9384(93)90204-S
   Lee JH, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20194924
   LI R, 2017, SCI REP UK, V7
   Ma LJ, 2004, DIABETES, V53, P336, DOI 10.2337/diabetes.53.2.336
   Macit C, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.00045
   Maiorino MI, 2015, ASIAN J ANDROL, V17, P5, DOI 10.4103/1008-682X.137687
   Malik VS, 2010, DIABETES CARE, V33, P2477, DOI 10.2337/dc10-1079
   Morelli A, 2019, AM J PHYSIOL-ENDOC M, V316, pE519, DOI 10.1152/ajpendo.00377.2018
   Musicki B, 2007, INT J IMPOT RES, V19, P129, DOI 10.1038/sj.ijir.3901494
   MYLROIE AA, 1986, TOXICOL APPL PHARM, V82, P512, DOI 10.1016/0041-008X(86)90286-3
   Nigro E, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/658913
   Nunes KP, 2012, CURR OPIN NEPHROL HY, V21, P163, DOI 10.1097/MNH.0b013e32835021bd
   Odegaard AO, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-016-0369-6
   Pagan LU, 2018, ARQ BRAS CARDIOL, V111, P540, DOI 10.5935/abc.20180211
   Paskaloglu K, 2004, EUR J PHARMACOL, V499, P345, DOI 10.1016/j.ejphar.2004.08.002
   Pérez-Martínez P, 2017, NUTR REV, V75, P307, DOI 10.1093/nutrit/nux014
   Radi R, 2018, P NATL ACAD SCI USA, V115, P5839, DOI 10.1073/pnas.1804932115
   Saboya PP, 2016, REV LAT-AM ENFERM, V24, DOI 10.1590/1518-8345.1573.2848
   Sandoo A, 2010, OPEN CARDIOVASC MED, V4, P302, DOI 10.2174/1874192401004010302
   Sener G, 2004, J PINEAL RES, V36, P232, DOI 10.1111/j.1600-079X.2004.00113.x
   Sener G, 2002, J UROLOGY, V167, P2624, DOI 10.1016/S0022-5347(05)65048-3
   Sener TE, 2020, J RES PHARM, V24, P318, DOI 10.35333/jrp.2020.153
   Sener TE, 2018, INT J IMPOT RES, V30, P179, DOI 10.1038/s41443-018-0042-6
   Tan HL, 2000, PHARMACOECONOMICS, V17, P77, DOI 10.2165/00019053-200017010-00006
   Wang RW, 2020, J SPORT HEALTH SCI, V9, P211, DOI 10.1016/j.jshs.2019.09.008
   Widdop RE, 1997, CLIN SCI, V93, P191, DOI 10.1042/cs0930191
   Wisse BE, 2004, J AM SOC NEPHROL, V15, P2792, DOI 10.1097/01.ASN.0000141966.69934.21
   Wong SK, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0123-9
NR 48
TC 8
Z9 10
U1 0
U2 13
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0955-9930
EI 1476-5489
J9 INT J IMPOT RES
JI Int. J. Impot. Res.
PD DEC
PY 2021
VL 33
IS 8
BP 844
EP 853
DI 10.1038/s41443-020-00356-w
EA OCT 2020
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA YP9AK
UT WOS:000574730800002
PM 33009496
OA Bronze
DA 2025-06-11
ER

PT J
AU Zhang, L
   Bruce-Keller, AJ
   Dasuri, K
   Nguyen, A
   Liu, Y
   Keller, JN
AF Zhang, Le
   Bruce-Keller, Annadora J.
   Dasuri, Kalavathi
   Nguyen, AnhThao
   Liu, Ying
   Keller, Jeffrey N.
TI Diet-induced metabolic disturbances as modulators of brain homeostasis
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Review
DE Aging; Brain; Diabetes; Metabolic syndrome; Neuron; Oxidative stress
ID INCREASED OXIDATIVE STRESS; TYPE-2 DIABETES-MELLITUS;
   INSULIN-RESISTANCE; ALZHEIMERS-DISEASE; MITOCHONDRIAL BIOGENESIS;
   LIPID-PEROXIDATION; COGNITIVE DECLINE; INDUCED OBESITY; RISK-FACTORS;
   DYSFUNCTION
AB A number of metabolic disturbances occur in response to the consumption of a high fat western diet. Such metabolic disturbances can include the progressive development of hyperglycemia, hyperinsulemia, obesity, metabolic syndrome, and diabetes. Cumulatively, diet-induced disturbances in metabolism are known to promote increased morbidity and negatively impact life expectancy through a variety of mechanisms. While the impact of metabolic disturbances on the hepatic, endocrine, and cardiovascular systems is well established there remains a noticeable void in understanding the basis by which the central nervous system (CNS) becomes altered in response to diet-induced metabolic dysfunction. In particular, it remains to be fully elucidated which established features of diet-induced pathogenesis (observed in non-CNS tissues) are recapitulated in the brain, and identification as to whether the observed changes in the brain are a direct or indirect effect of peripheral metabolic disturbances. This review will focus on each of these key issues and identify some critical experimental questions which remain to be elucidated experimentally, as well as provide an outline of our current understanding for how diet-induced alterations in metabolism may impact the brain during aging and age-related diseases of the nervous system. (C) 2008 Published by Elsevier B.V.
C1 [Zhang, Le; Bruce-Keller, Annadora J.; Dasuri, Kalavathi; Nguyen, AnhThao; Liu, Ying; Keller, Jeffrey N.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center
RP Keller, JN (corresponding author), Louisiana State Univ Syst, Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM jeffrey.keller@pbrc.edu
RI DASURI, KALAVATHI/E-7381-2012; Keller, Jeffrey/N-1975-2017;
   Bruce-Keller, Annadora/N-1954-2017
OI keller, jeffrey/0000-0002-9892-7423; Zhang, Le/0000-0001-7730-9266
FU NIA [AG029885, AG025771, AG005119]; Hibernia National Bank/Edward G.
   Schlieder Endowed Chair for Research; Alzhiemer's Association
FX This work was supported by grants to J.N. K. from the NIA (AG029885,
   AG025771, AG005119), the Hibernia National Bank/Edward G. Schlieder
   Endowed Chair for Research, and the Alzhiemer's Association.
CR Allen F.M., 1913, Studies Concerning Glycosuria and Diabetes
   Arvanitakis Z, 2006, NEUROLOGY, V67, P1960, DOI 10.1212/01.wnl.0000247053.45483.4e
   Bachman D, 2006, ANNU REV MED, V57, P499, DOI 10.1146/annurev.med.57.071604.141451
   Beeri MS, 2005, J GERONTOL A-BIOL, V60, P471, DOI 10.1093/gerona/60.4.471
   Beltowski J, 2000, J PHYSIOL PHARMACOL, V51, P883
   BURDO JR, 2008, NEUROBIOL AGING 0325
   Cao DF, 2007, J BIOL CHEM, V282, P36275, DOI 10.1074/jbc.M703561200
   Casadesus G, 2007, NEUROCHEM RES, V32, P717, DOI 10.1007/s11064-007-9296-y
   Castellani RJ, 2001, FREE RADICAL BIO MED, V31, P175, DOI 10.1016/S0891-5849(01)00570-6
   Castellani RJ, 2008, J NEUROPATH EXP NEUR, V67, P523, DOI 10.1097/NEN.0b013e318177eaf4
   Cecarini V, 2007, BBA-MOL CELL RES, V1773, P93, DOI 10.1016/j.bbamcr.2006.08.039
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Craft S, 2005, NEUROBIOL AGING, V26, pS65, DOI 10.1016/j.neurobiolaging.2005.08.021
   D Kuipers S, 2006, CURR OPIN DRUG DISC, V9, P580
   DeFronzo RA, 2004, MED CLIN N AM, V88, P787, DOI 10.1016/j.mcna.2004.04.013
   DIK MG, 2006, ALZHEIMERS DEMENT, V2, pS414
   Diniz YS, 2006, EUR J PHARMACOL, V543, P151, DOI 10.1016/j.ejphar.2006.05.039
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Elias PK, 1997, DIABETES CARE, V20, P1388, DOI 10.2337/diacare.20.9.1388
   Farr SA, 2008, ENDOCRINOLOGY, V149, P2628, DOI 10.1210/en.2007-1722
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Fridlyand LE, 2006, CURR DIABETES REV, V2, P241, DOI 10.2174/157339906776818541
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Goldstein Barry J, 2003, Rev Cardiovasc Med, V4 Suppl 6, pS3
   Granholm AC, 2008, J ALZHEIMERS DIS, V14, P133
   Haan MN, 2003, J AM GERIATR SOC, V51, P169, DOI 10.1046/j.1532-5415.2003.51054.x
   Haber EP, 2003, J CELL PHYSIOL, V194, P1, DOI 10.1002/jcp.10187
   Handschin C, 2006, ENDOCR REV, V27, P728, DOI 10.1210/er.2006-0037
   Iqbal N, 2007, VASC HEALTH RISK MAN, V3, P511
   Jeong SK, 2005, DEMENT GERIATR COGN, V19, P91, DOI 10.1159/000082659
   Joseph JA, 2005, NEUROCHEM RES, V30, P927, DOI 10.1007/s11064-005-6967-4
   Jovanovic JN, 1996, P NATL ACAD SCI USA, V93, P3679, DOI 10.1073/pnas.93.8.3679
   Jurdak N, 2008, NUTR NEUROSCI, V11, P48, DOI 10.1179/147683008X301333
   Kanoski SE, 2007, BEHAV BRAIN RES, V182, P57, DOI 10.1016/j.bbr.2007.05.004
   Keller JN, 2006, AGEING RES REV, V5, P1, DOI 10.1016/j.arr.2005.06.002
   Keller JN, 1998, REV NEUROSCIENCE, V9, P105
   Kelley DE, 2002, DIABETES, V51, P2944, DOI 10.2337/diabetes.51.10.2944
   Kumari M, 2000, J GERONTOL A-BIOL, V55, pB228, DOI 10.1093/gerona/55.5.B228
   Lau Francis C, 2007, Subcell Biochem, V42, P299
   Levin-Allerhand J A, 2002, J Nutr Health Aging, V6, P315
   Li ZG, 2007, DIABETES, V56, P1817, DOI 10.2337/db07-0171
   Linnarsson S, 1997, EUR J NEUROSCI, V9, P2581, DOI 10.1111/j.1460-9568.1997.tb01687.x
   Liu Y, 2008, NEUROSCIENCE, V153, P796, DOI 10.1016/j.neuroscience.2008.03.019
   Mantena SK, 2008, FREE RADICAL BIO MED, V44, P1259, DOI 10.1016/j.freeradbiomed.2007.12.029
   Matsuzawa-Nagata N, 2008, METABOLISM, V57, P1071, DOI 10.1016/j.metabol.2008.03.010
   MORIERA PI, 2008, FREE RADIC BIOL MED, V44, P1493
   Nisoli E, 2007, CIRC RES, V100, P795, DOI 10.1161/01.RES.0000259591.97107.6c
   Pasinetti Giulio Maria, 2007, V35, P159
   Raz I, 2005, DIABETES-METAB RES, V21, P3, DOI 10.1002/dmrr.493
   Razay G, 2007, ARCH NEUROL-CHICAGO, V64, P93, DOI 10.1001/archneur.64.1.93
   Refolo LM, 2000, NEUROBIOL DIS, V7, P321, DOI 10.1006/nbdi.2000.0304
   Ritov VB, 2005, DIABETES, V54, P8, DOI 10.2337/diabetes.54.1.8
   Shen X, 2004, AM J PHYSIOL-ENDOC M, V287, pE896, DOI 10.1152/ajpendo.00047.2004
   SMITH MA, 1994, P NATL ACAD SCI USA, V91, P5710, DOI 10.1073/pnas.91.12.5710
   Smith MA, 1996, DIABETOLOGIA, V39, P247, DOI 10.1007/BF00403972
   Sonnen JA, 2008, FREE RADICAL BIO MED, V45, P219, DOI 10.1016/j.freeradbiomed.2008.04.022
   Stranahan AM, 2008, NAT NEUROSCI, V11, P309, DOI 10.1038/nn2055
   Swerdlow RH, 2004, MED HYPOTHESES, V63, P8, DOI 10.1016/j.mehy.2003.12.045
   Swerdlow RH, 2007, CLIN INTERV AGING, V2, P347
   Taylor VH, 2007, OBES REV, V8, P409, DOI 10.1111/j.1467-789X.2007.00401.x
   Urakawa H, 2003, J CLIN ENDOCR METAB, V88, P4673, DOI 10.1210/jc.2003-030202
   VAAG A, 1999, DAN MED B, V46, P1234
   Valerio A, 2006, J CLIN INVEST, V116, P2791, DOI [10.1172/JCI28570, 10.1172/JCI28570.]
   Ward MA, 2005, BMC NEUROL, V5, DOI 10.1186/1471-2377-5-23
   Whitmer RA, 2005, BMJ-BRIT MED J, V330, P1360, DOI 10.1136/bmj.38446.466238.E0
   WINCOUR G, 2005, NEUROBIOL AGING, V26, P46
   Winocur G, 2005, BEHAV NEUROSCI, V119, P1389, DOI 10.1037/0735-7044.119.5.1389
   Wu AG, 2004, EUR J NEUROSCI, V19, P1699, DOI 10.1111/j.1460-9568.2004.03246.x
   Yaffe K, 2007, ALZ DIS ASSOC DIS, V21, P167, DOI 10.1097/WAD.0b013e318065bfd6
   Yaffe K, 2007, J AM GERIATR SOC, V55, P758, DOI 10.1111/j.1532-5415.2007.01139.x
   Zraika S, 2002, Obes Rev, V3, P103, DOI 10.1046/j.1467-789X.2002.00062.x
NR 71
TC 39
Z9 46
U1 1
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD MAY
PY 2009
VL 1792
IS 5
SI SI
BP 417
EP 422
DI 10.1016/j.bbadis.2008.09.006
PG 6
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 444CC
UT WOS:000265956700005
PM 18926905
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT B
AU Pasquali, R
AF Pasquali, Renato
BE Cizza, G
   Rother, KI
TI The hypothalamic-pituitary-adrenal axis and sex hormones in chronic
   stress and obesity: pathophysiological and clinical aspects
SO BRAIN AND OBESITY
SE Annals of the New York Academy of Sciences-Series
LA English
DT Article; Book Chapter
DE cortisol; androgens; stress; obesity
ID PLASMA-CORTISOL LEVELS; BODY-FAT DISTRIBUTION; 11-BETA-HYDROXYSTEROID
   DEHYDROGENASE TYPE-1; CORTICOTROPIN-RELEASING-FACTOR; METABOLIC
   SYNDROME; ABDOMINAL OBESITY; ALLOSTATIC LOAD; ARGININE-VASOPRESSIN;
   INSULIN-RESISTANCE; ADIPOSE-TISSUE
AB Obesity, particularly the abdominal phenotype, has been ascribed to an individual maladaptation to chronic environmental stress exposure mediated by a dysregulation of related neuroendocrine axes. Alterations in the control and action of the hypothalamic-pituitary-adrenal axis play a major role in this context, with the participation of the sympathetic nervous system. The ability to adapt to chronic stress may differ according to sex, with specific pathophysiological events leading to the development of stress-related chronic diseases. This seems to be influenced by the regulatory effects of sex hormones, particularly androgens. Stress may also disrupt the control of feeding, with some differences according to sex. Finally, the amount of experimental data in both animals and humans may help to shed more light on specific phenotypes of obesity, strictly related to the chronic exposure to stress. This challenge may potentially imply a different pathophysiological perspective and, possibly, a specific treatment.
C1 Univ Alma Mater Studiorum Bologna, Div Endocrinol, Dept Clin Med, S Orsola Malpighi Hosp, I-40138 Bologna, Italy.
C3 University of Bologna; IRCCS Azienda Ospedaliero-Universitaria di
   Bologna
RP Pasquali, R (corresponding author), Univ Alma Mater Studiorum Bologna, Div Endocrinol, Dept Clin Med, S Orsola Malpighi Hosp, Via Massarenti 9, I-40138 Bologna, Italy.
EM renato.pasquali@unibo.it
CR Adam TC, 2007, PHYSIOL BEHAV, V91, P449, DOI 10.1016/j.physbeh.2007.04.011
   ALDAMLUJI S, 1993, BAILLIERE CLIN ENDOC, V7, P355, DOI 10.1016/S0950-351X(05)80180-6
   Alevizaki M, 2007, METABOLISM, V56, P222, DOI 10.1016/j.metabol.2006.09.017
   Anagnostis P, 2009, J CLIN ENDOCR METAB, V94, P2692, DOI 10.1210/jc.2009-0370
   [Anonymous], 2005, IDF CONS WORLDW DEF
   Baid SK, 2009, J CLIN ENDOCR METAB, V94, P3857, DOI 10.1210/jc.2008-2766
   Bale TL, 2006, HORM BEHAV, V50, P529, DOI 10.1016/j.yhbeh.2006.06.033
   Barat P, 2007, ENDOCRINOLOGY, V148, P4836, DOI 10.1210/en.2007-0597
   Bartolomucci A, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004265
   Bellar A, 2008, J AM ACAD NURSE PRAC, V20, P128, DOI 10.1111/j.1745-7599.2007.00299.x
   BERTAGNA X, 1994, J CLIN ENDOCR METAB, V79, P390, DOI 10.1210/jc.79.2.390
   Bjorntorp P, 1993, Obes Res, V1, P206
   Björntorp P, 2000, INT J OBESITY, V24, pS80, DOI 10.1038/sj.ijo.0801285
   Bose M, 2009, CURR OPIN ENDOCRINOL, V16, P340, DOI 10.1097/MED.0b013e32832fa137
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   CHALEW S, 1995, OBES RES, V3, P371, DOI 10.1002/j.1550-8528.1995.tb00163.x
   Charmandari E, 2005, ANNU REV PHYSIOL, V67, P259, DOI 10.1146/annurev.physiol.67.040403.120816
   Chrousos GP, 1998, J CLIN ENDOCR METAB, V83, P1842, DOI 10.1210/jc.83.6.1842
   Chrousos GP, 1998, ANN NY ACAD SCI, V851, P311, DOI 10.1111/j.1749-6632.1998.tb09006.x
   CHROUSOS GP, 1992, JAMA-J AM MED ASSOC, V267, P1244, DOI 10.1001/jama.267.9.1244
   Cota D, 2001, Eat Weight Disord, V6, P205
   CULLINAN WE, 1995, NEUROSCIENCE, V64, P477, DOI 10.1016/0306-4522(94)00355-9
   Dallman MF, 2005, BRAIN BEHAV IMMUN, V19, P275, DOI 10.1016/j.bbi.2004.11.004
   Dallman MF, 2004, ENDOCRINOLOGY, V145, P2633, DOI 10.1210/en.2004-0037
   Dallman MF, 2003, P NATL ACAD SCI USA, V100, P11696, DOI 10.1073/pnas.1934666100
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   Dandona P, 2002, DIABETOLOGIA, V45, P924, DOI 10.1007/s00125-001-0766-5
   DINNEEN S, 1993, J CLIN INVEST, V92, P2283, DOI 10.1172/JCI116832
   Dodt C, 2003, ACTA PHYSIOL SCAND, V177, P351, DOI 10.1046/j.1365-201X.2003.01077.x
   Duclos M, 1999, J ENDOCRINOL INVEST, V22, P465, DOI 10.1007/BF03343591
   Epel E, 2001, PSYCHONEUROENDOCRINO, V26, P37, DOI 10.1016/S0306-4530(00)00035-4
   Epel EE, 1999, OBES RES, V7, P9, DOI 10.1002/j.1550-8528.1999.tb00385.x
   Fanelli F, 2011, STEROIDS, V76, P244, DOI 10.1016/j.steroids.2010.11.005
   Figueiredo H. F., 2003, EUR J NEUROSCI, P1
   Filaire E, 2001, EUR J APPL PHYSIOL, V86, P179, DOI 10.1007/s004210100512
   Filipovsky J, 1996, J HYPERTENS, V14, P229, DOI 10.1097/00004872-199602000-00012
   GALLUCCI WT, 1993, HEALTH PSYCHOL, V12, P420, DOI 10.1037/0278-6133.12.5.420
   Gruenewald TL, 2006, P NATL ACAD SCI USA, V103, P14158, DOI 10.1073/pnas.0606215103
   Hamer M, 2008, J AM COLL CARDIOL, V52, P2156, DOI 10.1016/j.jacc.2008.08.057
   Haslam DW, 2005, LANCET, V366, P1197, DOI 10.1016/S0140-6736(05)67483-1
   Herman JP, 1997, TRENDS NEUROSCI, V20, P78, DOI 10.1016/S0166-2236(96)10069-2
   Herman JP, 2003, FRONT NEUROENDOCRIN, V24, P151, DOI 10.1016/j.yfrne.2003.07.001
   Hjemdahl P, 2002, CIRCULATION, V106, P2634, DOI 10.1161/01.CIR.0000041502.43564.79
   Huizenga NATM, 1998, J CLIN ENDOCR METAB, V83, P47, DOI 10.1210/jc.83.1.47
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   Kalsbeek A, 2004, J NEUROSCI, V24, P7604, DOI 10.1523/JNEUROSCI.5328-03.2004
   Kanaya AM, 2003, AM J EPIDEMIOL, V158, P1161, DOI 10.1093/aje/kwg271
   KAPLAN HI, 1957, J NERV MENT DIS, V125, P181, DOI 10.1097/00005053-195704000-00004
   Karlamangla AS, 2006, PSYCHOSOM MED, V68, P500, DOI 10.1097/01.psy.0000221270.93985.82
   Karvonen MK, 2001, ATHEROSCLEROSIS, V159, P145, DOI 10.1016/S0021-9150(01)00468-3
   Killgore WDS, 2001, NEUROREPORT, V12, P2543, DOI 10.1097/00001756-200108080-00050
   Kirschbaum C, 1999, PSYCHOSOM MED, V61, P154, DOI 10.1097/00006842-199903000-00006
   Kirschbaum C, 1996, J CLIN ENDOCR METAB, V81, P3639, DOI 10.1210/jc.81.10.3639
   Kirschbaum C., 1992, J CLIN ENDOCR METAB, P15026
   KIRSCHNER MA, 1990, J CLIN ENDOCR METAB, V70, P473, DOI 10.1210/jcem-70-2-473
   Kudielka BM, 2005, BIOL PSYCHOL, V69, P113, DOI 10.1016/j.biopsycho.2004.11.009
   Kuo LE, 2007, NAT MED, V13, P803, DOI 10.1038/nm1611
   la Fleur SE, 2004, ENDOCRINOLOGY, V145, P2174, DOI 10.1210/en.2003-1359
   Lac G, 2000, J SPORT MED PHYS FIT, V40, P139
   Lado-Abeal J, 1998, J CLIN ENDOCR METAB, V83, P3083, DOI 10.1210/jc.83.9.3083
   Lavebratt C, 2006, INT J OBESITY, V30, P453, DOI 10.1038/sj.ijo.0803188
   LESNIEWSKA B, 1990, RES EXP MED, V190, P95, DOI 10.1007/PL00020011
   Levine AS, 1997, ANNU REV NUTR, V17, P597, DOI 10.1146/annurev.nutr.17.1.597
   Lightman SL, 2008, J NEUROENDOCRINOL, V20, P880, DOI 10.1111/j.1365-2826.2008.01711.x
   Lin RCY, 2003, HYPERTENSION, V41, P404, DOI 10.1161/01.HYP.0000055342.40301.DC
   Liu Y, 2008, ENDOCRINOLOGY, V149, P3512, DOI 10.1210/en.2008-0052
   Ljung T, 1996, OBES RES, V4, P277, DOI 10.1002/j.1550-8528.1996.tb00546.x
   LOEWY AD, 1993, BRAIN RES, V620, P323, DOI 10.1016/0006-8993(93)90174-L
   Ludwig DS., 2003, ASIA PAC J CLIN NUTR, V12, pS8
   LUITEN PGM, 1985, BRAIN RES, V329, P374, DOI 10.1016/0006-8993(85)90554-2
   MARIN P, 1992, METABOLISM, V41, P882, DOI 10.1016/0026-0495(92)90171-6
   McEwen BS, 2000, NEUROPSYCHOPHARMACOL, V22, P108, DOI 10.1016/S0893-133X(99)00129-3
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   Miyamoto J, 2007, MOL CELL BIOL, V27, P4807, DOI 10.1128/MCB.02039-06
   NORMAN RL, 1992, STEROIDS, V57, P37, DOI 10.1016/0039-128X(92)90094-P
   Oliver G, 2000, PSYCHOSOM MED, V62, P853, DOI 10.1097/00006842-200011000-00016
   Olsen D. H., 1987, J CLIN ENDOCR METAB, V65, P262
   Pasquali R, 2008, INT J OBESITY, V32, P1764, DOI 10.1038/ijo.2008.129
   Pasquali R, 1999, INT J OBESITY, V23, P419, DOI 10.1038/sj.ijo.0800838
   PASQUALI R, 1993, J CLIN ENDOCR METAB, V77, P341, DOI 10.1210/jc.77.2.341
   Pasquali R, 2002, J CLIN ENDOCR METAB, V87, P166, DOI 10.1210/jc.87.1.166
   Pasquali R, 1998, CLIN ENDOCRINOL, V48, P603, DOI 10.1046/j.1365-2265.1998.00458.x
   Pasquali R, 2000, CLIN ENDOCRINOL, V52, P413, DOI 10.1046/j.1365-2265.2000.00871.x
   Pasquali R, 2006, ANN NY ACAD SCI, V1083, P111, DOI 10.1196/annals.1367.009
   Pasquali R, 2006, FERTIL STERIL, V85, P1319, DOI 10.1016/j.fertnstert.2005.10.054
   Peeters F, 2003, PSYCHOSOM MED, V65, P836, DOI 10.1097/01.PSY.0000088594.17747.2E
   Phillips DIW, 1998, J CLIN ENDOCR METAB, V83, P757, DOI 10.1210/jc.83.3.757
   PLOTSKY PM, 1989, ENDOCR REV, V10, P437, DOI 10.1210/edrv-10-4-437
   Popkin BM, 2005, PHYSIOL BEHAV, V86, P603, DOI 10.1016/j.physbeh.2005.08.051
   Poretsky L, 1999, ENDOCR REV, V20, P535, DOI 10.1210/er.20.4.535
   Porte D, 2002, NUTR REV, V60, pS20, DOI 10.1301/002966402320634797
   Putnam K, 2005, J CLIN ENDOCR METAB, V90, P4224, DOI 10.1210/jc.2004-2525
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   REBUFFESCRIVE M, 1991, INT J OBESITY, V15, P83
   RIVIER C, 1991, BIOL REPROD, V45, P523, DOI 10.1095/biolreprod45.4.523
   Rosmond R, 1996, OBES RES, V4, P245, DOI 10.1002/j.1550-8528.1996.tb00542.x
   Rosmond R, 2005, PSYCHONEUROENDOCRINO, V30, P1, DOI 10.1016/j.psyneuen.2004.05.007
   Rosmond R, 2001, J ENDOCRINOL INVEST, V24, P639, DOI 10.1007/BF03343906
   Rosmond R, 1998, J CLIN ENDOCR METAB, V83, P1853, DOI 10.1210/jc.83.6.1853
   Roth J, 2004, OBES RES, V12, p88S, DOI 10.1038/oby.2004.273
   Rydrnark I, 2006, BIOL PSYCHIAT, V60, P867, DOI 10.1016/j.biopsych.2006.04.029
   Sainsbury A, 1997, DIABETOLOGIA, V40, P1269, DOI 10.1007/s001250050820
   SAMOJLIK E, 1984, J CLIN ENDOCR METAB, V59, P949, DOI 10.1210/jcem-59-5-949
   Sandeep TC, 2001, TRENDS ENDOCRIN MET, V12, P446, DOI 10.1016/S1043-2760(01)00499-4
   Sapolsky RM, 2000, ENDOCR REV, V21, P55, DOI 10.1210/er.21.1.55
   Sawchenko PE, 2000, PROG BRAIN RES, V122, P61
   Seckl JR, 2001, ENDOCRINOLOGY, V142, P1371, DOI 10.1210/en.142.4.1371
   Seeman TE, 2001, P NATL ACAD SCI USA, V98, P4770, DOI 10.1073/pnas.081072698
   Selye H, 1936, NATURE, V138, P32, DOI 10.1038/138032a0
   SHIPSTON MJ, 1992, ENDOCRINOLOGY, V130, P2213, DOI 10.1210/en.130.4.2213
   Shively C., 1989, ACTA MED SCAND, V723, P71
   Shively Ca, 2009, OBESITY SILVER SPRIN, V17, P1516
   Smith GD, 2005, CIRCULATION, V112, P332, DOI 10.1161/CIRCULATIONAHA.104.489088
   Smith SR, 1996, ENDOCRIN METAB CLIN, V25, P921, DOI 10.1016/S0889-8529(05)70362-5
   Steiner MA, 2008, PROG BRAIN RES, V170, P397, DOI 10.1016/S0079-6123(08)00433-0
   Stolk RP, 1996, J ENDOCRINOL, V149, P313, DOI 10.1677/joe.0.1490313
   STRACK AM, 1989, BRAIN RES, V491, P156, DOI 10.1016/0006-8993(89)90098-X
   STREETEN DHP, 1984, ENDOCR REV, V5, P371, DOI 10.1210/edrv-5-3-371
   Tilbrook AJ, 2000, REV REPROD, V5, P105, DOI 10.1530/ror.0.0050105
   Tomlinson JW, 2004, ENDOCR REV, V25, P831, DOI 10.1210/er.2003-0031
   van den Hoek AM, 2008, DIABETES, V57, P2304, DOI 10.2337/db07-1658
   van der Laan S, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004327
   van Praag HM, 2004, PROG NEURO-PSYCHOPH, V28, P891, DOI [10.1016/j.pnpbp.2004.05.031, 10.1080/15622970510030018]
   Veilleux A, 2010, J STEROID BIOCHEM, V122, P28, DOI 10.1016/j.jsbmb.2010.02.024
   Viau V, 2002, J NEUROENDOCRINOL, V14, P506, DOI 10.1046/j.1365-2826.2002.00798.x
   Viau V, 1996, J NEUROSCI, V16, P1866
   Vicennati V, 2004, J ENDOCRINOL INVEST, V27, P541, DOI 10.1007/BF03347476
   Vicennati V, 2009, OBESITY SILVER SPRIN, V17, P1676
   Vicennati V., 2000, J CLIN ENDOCR METAB, V24, P416
   Vicennati V, 2006, OBESITY, V14, P235, DOI 10.1038/oby.2006.30
   Vicennati V, 2011, NUTRITION, V27, P677, DOI 10.1016/j.nut.2010.07.016
   Vierhapper H, 2000, METABOLISM, V49, P229, DOI 10.1016/S0026-0495(00)91429-X
   Walker BR, 1998, HYPERTENSION, V31, P891, DOI 10.1161/01.HYP.31.4.891
   Ward AMV, 2003, CLIN ENDOCRINOL, V58, P500, DOI 10.1046/j.1365-2265.2003.01750.x
   Watson SL, 1998, ATHEROSCLEROSIS, V137, P259, DOI 10.1016/S0021-9150(97)00277-3
   Williamson M, 2005, PROG NEURO-PSYCHOPH, V29, P1239, DOI 10.1016/j.pnpbp.2005.08.009
   Wingenfeld K, 2010, PSYCHONEUROENDOCRINO, V35, P154, DOI 10.1016/j.psyneuen.2009.09.014
   Wizemann T. M., 2001, DOES SEX MATTER
   Wolak ML, 2003, J COMP NEUROL, V464, P285, DOI 10.1002/cne.10823
   Young E A, 1998, J Gend Specif Med, V1, P21
NR 140
TC 95
Z9 99
U1 1
U2 21
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
BN 978-1-57331-860-0
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2012
VL 1264
BP 20
EP 35
DI 10.1111/j.1749-6632.2012.06569.x
PG 16
WC Endocrinology & Metabolism; Multidisciplinary Sciences; Neurosciences
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Science & Technology - Other Topics;
   Neurosciences & Neurology
GA BDB65
UT WOS:000312490600004
PM 22612409
OA Green Published
DA 2025-06-11
ER

PT J
AU Marik, PE
   Raghavan, M
AF Marik, PE
   Raghavan, M
TI Stress-hyperglycemia, insulin and immunomodulation in sepsis
SO INTENSIVE CARE MEDICINE
LA English
DT Review
DE insulin; glucose; sepsis; sepsis syndrome; critical illness; insulin
   resistance; hyperglycemia
ID FACTOR-KAPPA-B; ACUTE MYOCARDIAL-INFARCTION; TYROSINE KINASE-ACTIVITY;
   ADMISSION PLASMA-GLUCOSE; INDEPENDENT RISK-FACTOR; CRITICALLY-ILL
   PATIENTS; MONONUCLEAR-CELLS MNC; NITRIC-OXIDE SYNTHASE;
   DIABETES-MELLITUS; SUBSTRATE UTILIZATION
AB Stress-hyperglycemia and insulin resistance are exceedingly common in critically ill patients, particularly those with sepsis. Multiple pathogenetic mechanisms are responsible for this metabolic syndrome; however, increased release of pro-inflammatory mediators and counter-regulatory hormones may play a pivotal role. Recent data suggests that hyperglycemia may potentiate the pro-inflammatory response while insulin has the opposite effect. Furthermore, emerging evidence suggests that tight glycemic control will improve the outcome of critically ill patients. This paper reviews the pathophysiology of stress hyperglycemia in the critically ill septic patient and outlines a treatment strategy for the management of this disorder.
C1 Univ Pittsburgh, Med Ctr, Dept Crit Care Med, Pittsburgh, PA 15261 USA.
   Conemaugh Mem Med Ctr, Johnstown, PA USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh
RP Univ Pittsburgh, Med Ctr, Dept Crit Care Med, 640A Scaife Hall,3550 Terrace St, Pittsburgh, PA 15261 USA.
EM maripe@ccm.upmc.edu
RI Marik, Paul/U-9733-2019
CR Agwunobi AO, 2000, J CLIN ENDOCR METAB, V85, P3770, DOI 10.1210/jc.85.10.3770
   Aljada A, 2002, J CLIN ENDOCR METAB, V87, P1419, DOI 10.1210/jc.87.3.1419
   Aljada A, 2000, METABOLISM, V49, P147, DOI 10.1016/S0026-0495(00)91039-4
   Aljada A, 2002, DIABETES, V51, pA537
   Aljada A, 2002, METABOLISM, V51, P487, DOI 10.1053/meta.2002.31339
   Aljada A, 2001, J CLIN ENDOCR METAB, V86, P3250, DOI 10.1210/jc.86.7.3250
   ALJADA A, 2003, J CLIN ENDOCRINOL ME
   Angus D C, 2001, Crit Care Med, V29, P1303, DOI 10.1097/00003246-200107000-00002
   Arnalich F, 2000, INFECT IMMUN, V68, P1942, DOI 10.1128/IAI.68.4.1942-1945.2000
   Barnes PJ, 1997, NEW ENGL J MED, V336, P1066, DOI 10.1056/NEJM199704103361506
   Belvin MP, 1996, ANNU REV CELL DEV BI, V12, P393, DOI 10.1146/annurev.cellbio.12.1.393
   BIRD TA, 1990, J BIOL CHEM, V265, P13578
   Bohrer H, 1997, J CLIN INVEST, V100, P972, DOI 10.1172/JCI119648
   BONE RC, 1992, CHEST, V101, P1481, DOI 10.1378/chest.101.6.1481
   Bone RC, 1997, CHEST, V112, P235, DOI 10.1378/chest.112.1.235
   Bone RC, 1996, CRIT CARE MED, V24, P1125, DOI 10.1097/00003246-199607000-00010
   Capes SE, 2001, STROKE, V32, P2426, DOI 10.1161/hs1001.096194
   CERIELLO A, 1993, DIABETOLOGIA, V36, P1119, DOI 10.1007/BF00401055
   Ceriello A, 1999, METABOLISM, V48, P1503, DOI 10.1016/S0026-0495(99)90237-8
   CERRA FB, 1987, SURGERY, V101, P1
   Chambrier C, 2000, CLIN SCI, V99, P321, DOI 10.1042/CS20000017
   Chettab K, 2002, THROMB HAEMOSTASIS, V87, P141
   CHIASSON JL, 1981, J CLIN INVEST, V68, P706, DOI 10.1172/JCI110306
   Christman JW, 1998, INTENS CARE MED, V24, P1131, DOI 10.1007/s001340050735
   CLOWES GHA, 1978, AM J SURG, V135, P577, DOI 10.1016/0002-9610(78)90040-5
   DAHN MS, 1985, ARCH SURG-CHICAGO, V120, P166
   Dandona P, 2001, J CLIN ENDOCR METAB, V86, P3257, DOI 10.1210/jc.86.7.3257
   Dandona P, 2003, DIABETES CARE, V26, P516, DOI 10.2337/diacare.26.2.516
   delaTorre A, 1999, J IMMUNOL, V162, P4101
   Dellinger R P, 1999, Minerva Anestesiol, V65, P340
   Dimitriadis G, 1997, BIOCHEM J, V321, P707, DOI 10.1042/bj3210707
   Dominici FP, 1999, AM J PHYSIOL-ENDOC M, V277, pE447, DOI 10.1152/ajpendo.1999.277.3.E447
   Eichacker PQ, 2002, AM J RESP CRIT CARE, V166, P1197, DOI 10.1164/rccm.200204-302OC
   Evans TW, 2001, NEW ENGL J MED, V345, P1417, DOI 10.1056/NEJM200111083451910
   Fink MP, 2003, CRIT CARE MED, V31, P2400, DOI 10.1097/01.CCM.0000084860.49412.10
   FRANKENFIELD DC, 1994, JPEN-PARENTER ENTER, V18, P398, DOI 10.1177/0148607194018005398
   Friedman G, 1998, CRIT CARE MED, V26, P2078, DOI 10.1097/00003246-199812000-00045
   Furnary AP, 1999, ANN THORAC SURG, V67, P352, DOI 10.1016/S0003-4975(99)00014-4
   Gao ZG, 2002, J BIOL CHEM, V277, P48115, DOI 10.1074/jbc.M209459200
   GAY NJ, 1991, NATURE, V351, P355, DOI 10.1038/351355b0
   Gelb AW, 2002, ANESTHESIOLOGY, V96, P1183, DOI 10.1097/00000542-200205000-00023
   Ghanim H, 2001, J CLIN ENDOCR METAB, V86, P1306, DOI 10.1210/jc.86.3.1306
   Giugliano D, 1997, CIRCULATION, V95, P1783
   GREEN CJ, 1995, CLIN SCI, V89, P601, DOI 10.1042/cs0890601
   Guha M, 2000, J BIOL CHEM, V275, P17728, DOI 10.1074/jbc.275.23.17728
   Hack CE, 1997, ADV IMMUNOL, V66, P101, DOI 10.1016/S0065-2776(08)60597-0
   Hansen TK, 2003, J CLIN ENDOCR METAB, V88, P1082, DOI 10.1210/jc.2002-021478
   HARING H, 1986, BIOCHEM J, V234, P59
   HART BB, 1989, CRIT CARE MED, V17, P1203, DOI 10.1097/00003246-198911000-00021
   Hoshino K, 1999, J IMMUNOL, V162, P3749
   Hotamisligil GS, 1996, SCIENCE, V271, P665, DOI 10.1126/science.271.5249.665
   HOTAMISLIGIL GS, 1994, P NATL ACAD SCI USA, V91, P4854, DOI 10.1073/pnas.91.11.4854
   HOTAMISLIGIL GS, 1994, J CLIN INVEST, V94, P1543, DOI 10.1172/JCI117495
   JEEVANANDAM M, 1990, J TRAUMA, V30, P582, DOI 10.1097/00005373-199005000-00010
   KANETY H, 1995, J BIOL CHEM, V270, P23780, DOI 10.1074/jbc.270.40.23780
   Khaodhiar L, 1999, Curr Opin Clin Nutr Metab Care, V2, P79, DOI 10.1097/00075197-199901000-00013
   Kwoun MO, 1997, JPEN-PARENTER ENTER, V21, P91, DOI 10.1177/014860719702100291
   LANG CH, 1992, AM J PHYSIOL, V263, pE703, DOI 10.1152/ajpendo.1992.263.4.E703
   LANG CH, 1991, ENDOCRINOLOGY, V128, P645, DOI 10.1210/endo-128-2-645
   Laroux FS, 2000, ANTIOXID REDOX SIGN, V2, P391, DOI 10.1089/15230860050192161
   Liu SF, 1999, CIRCULATION, V100, P1330, DOI 10.1161/01.CIR.100.12.1330
   Malmberg K, 1999, CIRCULATION, V99, P2626, DOI 10.1161/01.CIR.99.20.2626
   Malmberg K, 1997, BRIT MED J, V314, P1512, DOI 10.1136/bmj.314.7093.1512
   MALMBERG K, 1995, J AM COLL CARDIOL, V26, P57, DOI 10.1016/0735-1097(95)00126-K
   Marik PE, 2001, CRIT CARE MED, V29, P2264, DOI 10.1097/00003246-200112000-00005
   Marik PE, 2003, INTENS CARE MED, V29, P867, DOI 10.1007/s00134-003-1744-9
   Marik PE, 2002, CRIT CARE MED, V30, P2393, DOI 10.1097/00003246-200210000-00042
   Marik PE, 2002, CHEST, V122, P1784, DOI 10.1378/chest.122.5.1784
   Marik PE, 2001, DM-DIS MON, V47, P465, DOI 10.1067/mda.2001.119745
   MARIK PE, 2003, INTENSIVE CARE MED
   Martin GS, 2003, NEW ENGL J MED, V348, P1546, DOI 10.1056/NEJMoa022139
   McCowen KC, 2001, CRIT CARE CLIN, V17, P107, DOI 10.1016/S0749-0704(05)70154-8
   McManus LM, 2001, J LEUKOCYTE BIOL, V70, P395
   MEHTA VK, 1994, EUR J ENDOCRINOL, V130, P208, DOI 10.1530/eje.0.1300208
   Meldrum DR, 1997, J TRAUMA, V43, P888, DOI 10.1097/00005373-199712000-00003
   Mesotten D, 2002, J CLIN ENDOCR METAB, V87, P5516, DOI 10.1210/jc.2002-020664
   MESZAROS K, 1987, BIOCHEM BIOPH RES CO, V149, P1, DOI 10.1016/0006-291X(87)91596-8
   Mizock BA, 2001, BEST PRACT RES CL EN, V15, P533, DOI 10.1053/beem.2001.0168
   MIZOCK BA, 1997, ENDOCRINOLOGY CRITIC, P197
   Mohanty P, 2000, J CLIN ENDOCR METAB, V85, P2970, DOI 10.1210/jc.85.8.2970
   Mowlavi A, 2000, ANN PLAS SURG, V45, P629, DOI 10.1097/00000637-200045060-00010
   Multz Alan S, 2003, Semin Respir Infect, V18, P68
   Natanson C, 1998, CRIT CARE MED, V26, P1927, DOI 10.1097/00003246-199812000-00001
   NIELSON CP, 1989, DIABETES, V38, P1031, DOI 10.2337/diabetes.38.8.1031
   Norhammar AM, 1999, DIABETES CARE, V22, P1827, DOI 10.2337/diacare.22.11.1827
   Nunes ALB, 2001, LIFE SCI, V69, P2103, DOI 10.1016/S0024-3205(01)01288-7
   Pahl HL, 1999, ONCOGENE, V18, P6853, DOI 10.1038/sj.onc.1203239
   Paterson RL, 2000, CRIT CARE MED, V28, P1047, DOI 10.1097/00003246-200004000-00022
   Paz K, 1997, J BIOL CHEM, V272, P29911, DOI 10.1074/jbc.272.47.29911
   Peng HB, 1998, J IMMUNOL, V161, P1970
   Pessin JE, 2000, J CLIN INVEST, V106, P165, DOI 10.1172/JCI10582
   PETIT F, 1995, AM J PHYSIOL-ENDOC M, V268, pE219, DOI 10.1152/ajpendo.1995.268.2.E219
   POZZILLI P, 1994, DIABETIC MED, V11, P935, DOI 10.1111/j.1464-5491.1994.tb00250.x
   Rassias AJ, 1999, ANESTH ANALG, V88, P1011, DOI 10.1097/00000539-199905000-00008
   ROH MS, 1986, METABOLISM, V35, P419, DOI 10.1016/0026-0495(86)90131-9
   Saeed M, 1999, BRIT J SURG, V86, P813, DOI 10.1046/j.1365-2168.1999.01140.x
   Sakurai Y, 1996, AM J PHYSIOL-ENDOC M, V270, pE864, DOI 10.1152/ajpendo.1996.270.5.E864
   Shepherd PR, 1999, NEW ENGL J MED, V341, P248, DOI 10.1056/NEJM199907223410406
   SIEGEL JH, 1979, SURGERY, V86, P163
   Smith TR, 1997, AM J PHYSIOL-ENDOC M, V272, pE1071, DOI 10.1152/ajpendo.1997.272.6.E1071
   Spiecker M, 1998, J LEUKOCYTE BIOL, V63, P732, DOI 10.1002/jlb.63.6.732
   Spiecker M, 1997, J BIOL CHEM, V272, P30969, DOI 10.1074/jbc.272.49.30969
   Standiford TJ, 1996, J LEUKOCYTE BIOL, V59, P24, DOI 10.1002/jlb.59.1.24
   Straczkowski M, 2002, J CLIN ENDOCR METAB, V87, P4602, DOI 10.1210/jc.2002-020135
   Van den Berghe G, 2003, CRIT CARE MED, V31, P359, DOI 10.1097/01.CCM.0000045568.12881.10
   Van den Berghe G, 2002, CRIT CARE CLIN, V18, P509, DOI 10.1016/S0749-0704(02)00007-6
   Van den Berghe G, 2001, NEW ENGL J MED, V345, P1359, DOI 10.1056/NEJMoa011300
   Walley KR, 1999, AM J RESP CRIT CARE, V160, P698, DOI 10.1164/ajrccm.160.2.9809081
   Wayman NS, 2002, FASEB J, V16, P1027, DOI 10.1096/fj.01-0793com
   Wolfe RR, 1997, BAILLIERE CLIN ENDOC, V11, P645, DOI 10.1016/S0950-351X(97)80926-3
   WOO J, 1990, ARCH NEUROL-CHICAGO, V47, P1174, DOI 10.1001/archneur.1990.00530110028011
   Yorek MA, 2002, METABOLISM, V51, P225, DOI 10.1053/meta.2002.29958
   Yue TL, 2001, CIRCULATION, V104, P2588, DOI 10.1161/hc4601.099403
   Zerr KJ, 1997, ANN THORAC SURG, V63, P356
   Zindrou D, 2001, DIABETES CARE, V24, P1634, DOI 10.2337/diacare.24.9.1634
NR 115
TC 281
Z9 322
U1 1
U2 32
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0342-4642
EI 1432-1238
J9 INTENS CARE MED
JI Intensive Care Med.
PD MAY
PY 2004
VL 30
IS 5
BP 748
EP 756
DI 10.1007/s00134-004-2167-y
PG 9
WC Critical Care Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 817BW
UT WOS:000221154000006
PM 14991101
DA 2025-06-11
ER

PT J
AU Ellison, PT
AF Ellison, Peter T.
TI Fetal Programming and Fetal Psychology
SO INFANT AND CHILD DEVELOPMENT
LA English
DT Article
DE fetal programming hypothesis; evolutionary biology
ID CONGENITAL ADRENAL-HYPERPLASIA; PREDICTIVE ADAPTIVE RESPONSE;
   CORONARY-HEART-DISEASE; METABOLIC SYNDROME; BIRTH-WEIGHT; MATERNAL-CARE;
   BREAST-CANCER; DEVELOPMENTAL PLASTICITY; INSULIN-RESISTANCE; PRENATAL
   STRESS
AB The introduction of the 'fetal programming hypothesis', first in epidemiology, subsequently in a broad range of disciplines concerned with developmental biology, has generated new interest in phenotypic plasticity, the mechanisms that govern it, and its place in evolutionary biology. A number of epidemiological studies link small size at birth, assumed to be a consequence of constrained prenatal energy availability, with adverse effects on the risk of chronic diseases later in life. The cluster of chronic diseases associated with the metabolic syndrome and alterations of glucose metabolism are particularly implicated. Recent evidence suggests that epigenetic modification of gene expression affecting the hypothalamic-pituitary-adrenal (HPA) axis may be involved in these effects. In animal studies epigenetic alteration of HPA axis activity and responsiveness is associated with changes in adult behaviour and stress responsiveness. The potential for similar effects to contribute to psychological and psychiatric outcomes in humans has been explored in a number of contexts, including famine exposure, observed covariance with birth weight, and prenatal dexamethasone treatment of fetuses at risk of congenital adrenal hyperplasia. While fetal programming effects have now been widely demonstrated across species and human populations, the adaptive significance of these effects is still a matter of debate. Copyright (C) 2010 John Wiley & Sons, Ltd.
C1 Harvard Univ, Dept Human Evolutionary Biol, Peabody Museum, Cambridge, MA 02138 USA.
C3 Harvard University
RP Ellison, PT (corresponding author), Harvard Univ, Dept Human Evolutionary Biol, Peabody Museum, Cambridge, MA 02138 USA.
EM pellison@fas.harvard.edu
CR Arlt W, 2007, HORM RES, V68, P158, DOI 10.1159/000110615
   Badyaev AV, 2008, ANN NY ACAD SCI, V1133, P151, DOI 10.1196/annals.1438.009
   Baek D, 2008, NATURE, V455, P64, DOI 10.1038/nature07242
   Barbieri RL, 2008, J CLIN ENDOCR METAB, V93, P2439, DOI 10.1210/jc.2008-0752
   BARKER DJP, 1989, LANCET, V2, P577
   BARKER DJP, 1989, BMJ-BRIT MED J, V298, P564, DOI 10.1136/bmj.298.6673.564
   Barker DJP, 2005, NEW ENGL J MED, V353, P1802, DOI 10.1056/NEJMoa044160
   BARKER DJP, 1995, BRIT MED J, V311, P171, DOI 10.1136/bmj.311.6998.171
   Barker DJP, 2002, INT J EPIDEMIOL, V31, P1235, DOI 10.1093/ije/31.6.1235
   Barnett AH, 2006, DIABETOLOGIA, V49, P2234, DOI 10.1007/s00125-006-0325-1
   Bateson P, 2004, NATURE, V430, P419, DOI 10.1038/nature02725
   Beaulieu LM, 2007, BIOESSAYS, V29, P1029, DOI 10.1002/bies.20640
   Bhargava SK, 2004, NEW ENGL J MED, V350, P865, DOI 10.1056/NEJMoa035698
   Bréant B, 2006, HORM RES, V65, P98, DOI 10.1159/000091513
   Brenner B M, 1993, Curr Opin Nephrol Hypertens, V2, P691
   Burton CL, 2007, BRAIN RES, V1158, P28, DOI 10.1016/j.brainres.2007.05.003
   Cameron N, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002210
   Candib LM, 2007, ANN FAM MED, V5, P547, DOI 10.1370/afm.754
   Cavalli G, 2006, DEVELOPMENT, V133, P2089, DOI 10.1242/dev.02402
   Champagne DL, 2008, J NEUROSCI, V28, P6037, DOI 10.1523/JNEUROSCI.0526-08.2008
   Champagne FA, 2006, ENDOCRINOLOGY, V147, P2909, DOI 10.1210/en.2005-1119
   CLARKE AS, 1994, DEV PSYCHOBIOL, V27, P257, DOI 10.1002/dev.420270502
   Costello EJ, 2007, ARCH GEN PSYCHIAT, V64, P338, DOI 10.1001/archpsyc.64.3.338
   Daryani A, 2005, ETHNIC DIS, V15, P213
   de Rooij SR, 2006, PSYCHONEUROENDOCRINO, V31, P1257, DOI 10.1016/j.psyneuen.2006.09.007
   Dwivedi S, 2004, Indian Heart J, V56, P258
   Ellison PT, 2007, AM J HUM BIOL, V19, P622, DOI 10.1002/ajhb.20662
   Eriksson J, 2000, HYPERTENSION, V36, P790, DOI 10.1161/01.HYP.36.5.790
   Eriksson M, 2004, J INTERN MED, V255, P236, DOI 10.1046/j.1365-2796.2003.01289.x
   Fleury L, 2008, ONCOGENE, V27, P4075, DOI 10.1038/onc.2008.41
   FOREST MG, 1989, ENDOCR RES, V15, P277, DOI 10.1080/07435808909039101
   Foucan L, 2006, DIABETES METAB, V32, P337, DOI 10.1016/S1262-3636(07)70288-4
   Fowden AL, 2001, BRIT MED BULL, V60, P123, DOI 10.1093/bmb/60.1.123
   Fraga MF, 2005, P NATL ACAD SCI USA, V102, P10604, DOI 10.1073/pnas.0500398102
   Gitau R, 2001, Stress, V4, P195
   Gitau R, 2001, J CLIN ENDOCR METAB, V86, P104, DOI 10.1210/jc.86.1.104
   Gluckman P, 2006, DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, P1, DOI 10.2277/ 0521847435
   Gluckman P., 2005, FETAL MATRIX
   Gluckman P., 2008, Mismatch: the Lifestyle Diseases Timebomb
   Gluckman PD, 2005, TRENDS ECOL EVOL, V20, P527, DOI 10.1016/j.tree.2005.08.001
   Gluckman PD, 2004, PEDIATR RES, V56, P311, DOI 10.1203/01.PDR.0000135998.08025.FB
   Gluckman PD, 2008, NEW ENGL J MED, V359, P61, DOI 10.1056/NEJMra0708473
   Gluckman PD, 2007, P NATL ACAD SCI USA, V104, P12796, DOI 10.1073/pnas.0705667104
   Gluckman PD, 2009, LANCET, V373, P1654, DOI 10.1016/S0140-6736(09)60234-8
   Godfrey KM, 2007, PEDIATR RES, V61, p5R, DOI 10.1203/pdr.0b013e318045bedb
   Goldberg AD, 2007, CELL, V128, P635, DOI 10.1016/j.cell.2007.02.006
   Henckel A, 2007, BIOESSAYS, V29, P520, DOI 10.1002/bies.20591
   Hirvikoski T, 2007, J CLIN ENDOCR METAB, V92, P542, DOI 10.1210/jc.2006-1340
   Hughes IA, 2003, GROWTH HORM IGF RES, V13, pS55, DOI 10.1016/S1096-6374(03)00056-X
   Ismail-Beigi F, 2006, AM J PHYSIOL-ENDOC M, V291, pE439, DOI 10.1152/ajpendo.00105.2006
   Jasienska G, 2006, AM J HUM BIOL, V18, P133, DOI 10.1002/ajhb.20462
   Jasienska G, 2006, P NATL ACAD SCI USA, V103, P12759, DOI 10.1073/pnas.0605488103
   Jones JH, 2005, AM J HUM BIOL, V17, P22, DOI 10.1002/ajhb.20099
   Jordan VC, 2007, JNCI-J NATL CANCER I, V99, P1655, DOI 10.1093/jnci/djm230
   Kaplan LA, 2008, EARLY HUM DEV, V84, P249, DOI 10.1016/j.earlhumdev.2007.06.004
   Kapoor A, 2008, ENDOCRINOLOGY, V149, P6406, DOI 10.1210/en.2008-0347
   Kuh D, 2003, J EPIDEMIOL COMMUN H, V57, P778, DOI 10.1136/jech.57.10.778
   Kuzawa CW, 2005, AM J HUM BIOL, V17, P5, DOI 10.1002/ajhb.20091
   Lajic Svetlana, 2008, V13, P82, DOI 10.1159/000134827
   LAKSHMI V, 1993, J STEROID BIOCHEM, V45, P391, DOI 10.1016/0960-0760(93)90008-K
   Leader JE, 2006, BIOCHEM PHARMACOL, V72, P1589, DOI 10.1016/j.bcp.2006.05.024
   Lillycrop KA, 2005, J NUTR, V135, P1382, DOI 10.1093/jn/135.6.1382
   Lillycrop KA, 2007, BRIT J NUTR, V97, P1064, DOI 10.1017/S000711450769196X
   Lob-Corzilius T, 2007, INT J HYG ENVIR HEAL, V210, P585, DOI 10.1016/j.ijheh.2007.07.019
   MACKENZIE HS, 1995, AM J KIDNEY DIS, V26, P91, DOI 10.1016/0272-6386(95)90161-2
   McCalla CO, 1998, STEROIDS, V63, P511, DOI 10.1016/S0039-128X(98)00056-7
   Meaney Michael J, 2005, Dialogues Clin Neurosci, V7, P103
   Meaney MJ, 2005, TRENDS NEUROSCI, V28, P456, DOI 10.1016/j.tins.2005.07.006
   MEANEY MJ, 1994, ANN NY ACAD SCI, V746, P260
   MEANEY MJ, 1991, PSYCHONEUROENDOCRINO, V16, P85, DOI 10.1016/0306-4530(91)90072-2
   Michels KB, 2006, INT J CANCER, V119, P2007, DOI 10.1002/ijc.22004
   Michels KB, 2006, CARCINOGENESIS, V27, P2464, DOI 10.1093/carcin/bgl105
   Miller WL, 1999, J UROLOGY, V162, P537, DOI 10.1016/S0022-5347(05)68624-7
   Misra A, 2004, NUTRITION, V20, P482, DOI 10.1016/j.nut.2004.01.020
   Misra A, 2003, METAB SYNDR RELAT D, V1, P277, DOI 10.1089/1540419031361390
   Misra KB, 2005, ETHNIC DIS, V15, P627
   Morgan HD, 2005, HUM MOL GENET, V14, pR47, DOI 10.1093/hmg/ddi114
   Nelson R. J., 2005, An Introduction to Behavioral Endocrinology
   New MI, 2004, ANN NY ACAD SCI, V1038, P14, DOI 10.1196/annals.1315.009
   OHKAWA T, 1991, EXP CLIN ENDOCRINOL, V98, P123, DOI 10.1055/s-0029-1211108
   Ong KK, 2006, HORM RES, V65, P65, DOI 10.1159/000091508
   Pang SY, 1997, ENDOCRIN METAB CLIN, V26, P853, DOI 10.1016/S0889-8529(05)70285-1
   Pham TD, 2003, AM J PHYSIOL-REG I, V285, pR962, DOI 10.1152/ajpregu.00201.2003
   PHILLIPS DIW, 1994, DIABETOLOGIA, V37, P150, DOI 10.1007/s001250050086
   Pousada JMDC, 2006, DIABETES RES CLIN PR, V72, P75, DOI 10.1016/j.diabres.2005.09.006
   Rich-Edwards JW, 1999, ANN INTERN MED, V130, P278, DOI 10.7326/0003-4819-130-4_Part_1-199902160-00005
   Rich-Edwards JW, 2005, BMJ-BRIT MED J, V330, P1115, DOI 10.1136/bmj.38434.629630.E0
   Rickard IJ, 2007, TRENDS ENDOCRIN MET, V18, P94, DOI 10.1016/j.tem.2007.02.004
   Schwingel A, 2007, EUR J CARDIOV PREV R, V14, P508, DOI 10.1097/HJR.0b013e3280117244
   Sebaai N, 2002, NEUROENDOCRINOLOGY, V76, P243, DOI 10.1159/000065947
   SPEISER PW, 1994, J PEDIATR ENDOCRINOL, V7, P183
   STEIN Z, 1972, SCIENCE, V178, P708, DOI 10.1126/science.178.4062.708
   Susser E, 1998, AM J EPIDEMIOL, V147, P213
   Susser E, 1998, BIOL PSYCHIAT, V44, P141, DOI 10.1016/S0006-3223(97)00427-7
   Susser E, 1996, ARCH GEN PSYCHIAT, V53, P25
   SUSSER ES, 1992, ARCH GEN PSYCHIAT, V49, P983
   Susser E, 2008, ANN NY ACAD SCI, V1136, P185, DOI 10.1196/annals.1425.024
   Trayhurn P, 2005, ACTA PHYSIOL SCAND, V184, P285, DOI 10.1111/j.1365-201X.2005.01468.x
   Tull ES, 2005, REV PANAM SALUD PUBL, V18, P418, DOI 10.1590/S1020-49892005001000005
   Vickers MH, 2005, ENDOCRINOLOGY, V146, P4211, DOI 10.1210/en.2005-0581
   Weaver ICG, 2006, P NATL ACAD SCI USA, V103, P3480, DOI 10.1073/pnas.0507526103
   Weaver ICG, 2004, NAT NEUROSCI, V7, P847, DOI 10.1038/nn1276
   Weinstock M, 1997, NEUROSCI BIOBEHAV R, V21, P1, DOI 10.1016/S0149-7634(96)00014-0
   West-Eberhard Mary Jane, 2003, pi
   Worthman CM, 2005, AM J HUM BIOL, V17, P95, DOI 10.1002/ajhb.20096
   Wu Y, 2006, EPIGENETICS-US, V1, P106, DOI 10.4161/epi.1.2.2766
   Wyrwoll CS, 2006, ENDOCRINOLOGY, V147, P599, DOI 10.1210/en.2005-0748
   Zhou XC, 2007, GYNECOL ONCOL, V107, P143, DOI 10.1016/j.ygyno.2007.06.019
NR 108
TC 16
Z9 23
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1522-7227
EI 1522-7219
J9 INFANT CHILD DEV
JI Infant Child Dev.
PD JAN-FEB
PY 2010
VL 19
IS 1
SI SI
BP 6
EP 20
DI 10.1002/icd.649
PG 15
WC Psychology, Developmental
WE Social Science Citation Index (SSCI)
SC Psychology
GA 562SN
UT WOS:000275075100002
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Nader, N
   Chrousos, GP
   Kino, T
AF Nader, Nancy
   Chrousos, George P.
   Kino, Tomoshige
TI Interactions of the circadian CLOCK system and the HPA axis
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID REV-ERB-ALPHA; METABOLIC SYNDROME; PERIPHERAL-TISSUES; GENE-EXPRESSION;
   TRANSCRIPTION FACTOR; STRIA TERMINALIS; CENTRAL NUCLEUS; ADRENAL-GLAND;
   OVAL NUCLEUS; SHIFT WORK
AB Organisms have developed concurrent behavioral and physiological adaptations to the strong influence of day/night cycles, as well as to unforeseen, random stress stimuli. These circadian and stress-related responses are achieved by two highly conserved and interrelated regulatory networks, the circadian CLOCK and stress systems, which respectively consist of oscillating molecular pacemakers, the Clock/Bmal1 transcription factors, and the hypothalamic-pituitary-adrenal (HPA) axis and its end-effector, the glucocorticoid receptor. These systems communicate with one another at different signaling levels and dysregulation of either system can lead to development of pathologic conditions. In this review, we summarize the mutual physiologic interactions between the circadian CLOCK system and the HPA axis, and discuss their clinical implications.
C1 [Nader, Nancy; Kino, Tomoshige] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Unit Mol Hormone Act, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20892 USA.
   [Chrousos, George P.] Univ Athens, Sch Med, Dept Pediat 1, GR-11527 Athens, Greece.
C3 National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver
   National Institute of Child Health & Human Development (NICHD); Athens
   Medical School; National & Kapodistrian University of Athens
RP Kino, T (corresponding author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Unit Mol Hormone Act, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20892 USA.
EM kinot@mail.nih.gov
RI Chrousos, George/G-8702-2011; Nader, Nader/E-6358-2014
OI Nader, Nader/0000-0002-5744-7319
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development, National Institutes of Health, Bethesda, MD
FX Literary work of this article was funded partly by the Intramural
   Research Program of the Eunice Kennedy Shriver National Institute of
   Child Health and Human Development, National Institutes of Health,
   Bethesda, MD.
CR [Anonymous], INT J OBESITY
   [Anonymous], 2000, GENE DEV, DOI DOI 10.1101/gad.183500
   [Anonymous], PLOS BIOL
   [Anonymous], HDB STRESS BRAIN, DOI DOI 10.1016/j.neuropharm.2008.06.046
   Arjona A, 2008, NEUROCHEM RES, V33, P708, DOI 10.1007/s11064-007-9501-z
   Balsalobre A, 2000, SCIENCE, V289, P2344, DOI 10.1126/science.289.5488.2344
   Bao AM, 2008, BRAIN RES REV, V57, P531, DOI 10.1016/j.brainresrev.2007.04.005
   Burioka N, 2007, J PHARMACOL SCI, V103, P144, DOI 10.1254/jphs.FMJ06003X4
   Cermakian N, 2000, NAT REV MOL CELL BIO, V1, P59, DOI 10.1038/35036078
   Chrousos G P., 2001, Endocrinology Metabolism, P609, DOI DOI 10.1016/j.cell.2006.03.033
   Chrousos GP, 2007, STRESS, V10, P213, DOI 10.1080/10253890701292119
   Chrousos George P, 2005, Sci STKE, V2005, ppe48, DOI 10.1126/stke.3042005pe48
   Chrousos GP, 2009, NAT REV ENDOCRINOL, V5, P374, DOI 10.1038/nrendo.2009.106
   CHROUSOS GP, 1995, NEW ENGL J MED, V332, P1351, DOI 10.1056/NEJM199505183322008
   Dallmann R, 2006, J COMP PHYSIOL A, V192, P769, DOI 10.1007/s00359-006-0114-9
   Doi M, 2006, CELL, V125, P497, DOI 10.1016/j.cell.2006.03.033
   Duez H, 2008, FEBS LETT, V582, P19, DOI 10.1016/j.febslet.2007.08.032
   Ekstrand K, 1996, ANGIOLOGY, V47, P1089, DOI 10.1177/000331979604701109
   Friedman TC, 1996, ENDOCR J, V43, P645, DOI 10.1507/endocrj.43.645
   Fujino Y, 2006, AM J EPIDEMIOL, V164, P128, DOI 10.1093/aje/kwj185
   Fukuoka Y, 2005, J BIOL RHYTHM, V20, P550, DOI 10.1177/0748730405279866
   Fuller PM, 2008, SCIENCE, V320, P1074, DOI 10.1126/science.1153277
   Gómez-Abellán P, 2008, INT J OBESITY, V32, P121, DOI 10.1038/sj.ijo.0803689
   Hastings M, 2007, J ENDOCRINOL, V195, P187, DOI 10.1677/JOE-07-0378
   Ishida A, 2005, CELL METAB, V2, P297, DOI 10.1016/j.cmet.2005.09.009
   Kalsbeek A, 2006, J BIOL RHYTHM, V21, P458, DOI 10.1177/0748730406293854
   Kino T, 2004, ESSAYS BIOCHEM, V40, P137, DOI 10.1042/bse0400137
   Kiyohara YB, 2006, P NATL ACAD SCI USA, V103, P10074, DOI 10.1073/pnas.0601416103
   Ko CH, 2006, HUM MOL GENET, V15, pR271, DOI 10.1093/hmg/ddl207
   Kondratov RV, 2006, CELL CYCLE, V5, P890, DOI 10.4161/cc.5.8.2684
   Kraves S, 2006, NAT NEUROSCI, V9, P212, DOI 10.1038/nn1633
   Liu JG, 2006, INFECT IMMUN, V74, P4750, DOI 10.1128/IAI.00287-06
   Meijer JH, 2003, J BIOL RHYTHM, V18, P235, DOI 10.1177/0748730403253370
   Mori Kenji, 2008, V46, P201, DOI 10.1007/400_2007_054
   Nader N, 2009, FASEB J, V23, P1572, DOI 10.1096/fj.08-117697
   Oishi K, 2006, J THROMB HAEMOST, V4, P1774, DOI 10.1111/j.1538-7836.2006.02032.x
   Oishi K, 2005, DNA RES, V12, P191, DOI 10.1093/dnares/dsi003
   Oishi K, 2009, CLIN EXP HYPERTENS, V31, P208, DOI 10.1080/10641960902822468
   Oishi K, 2009, J MOL CELL CARDIOL, V46, P545, DOI 10.1016/j.yjmcc.2009.01.001
   Oster H, 2006, CELL METAB, V4, P163, DOI 10.1016/j.cmet.2006.07.002
   Panda S, 2002, CELL, V109, P307, DOI 10.1016/S0092-8674(02)00722-5
   Pilorz V, 2009, PHYSIOL BEHAV, V96, P57, DOI 10.1016/j.physbeh.2008.08.010
   Reddy AB, 2007, HEPATOLOGY, V45, P1478, DOI 10.1002/hep.21571
   Rhen T, 2005, NEW ENGL J MED, V353, P1711, DOI 10.1056/NEJMra050541
   Ripperger JRA, 2006, NAT GENET, V38, P369, DOI 10.1038/ng1738
   Scheer FAJL, 2009, P NATL ACAD SCI USA, V106, P4453, DOI 10.1073/pnas.0808180106
   Scott EM, 2008, INT J OBESITY, V32, P658, DOI 10.1038/sj.ijo.0803778
   Segall LA, 2008, NEUROSCIENCE, V157, P52, DOI 10.1016/j.neuroscience.2008.08.055
   Segall LA, 2006, NEUROSCIENCE, V140, P753, DOI 10.1016/j.neuroscience.2006.03.037
   Segall LA, 2009, NEUROSCI LETT, V457, P58, DOI 10.1016/j.neulet.2009.03.083
   So AYL, 2009, P NATL ACAD SCI USA, V106, P17582, DOI 10.1073/pnas.0909733106
   Sookoian S, 2007, J INTERN MED, V261, P285, DOI 10.1111/j.1365-2796.2007.01766.x
   Sookoian S, 2008, AM J CLIN NUTR, V87, P1606, DOI 10.1093/ajcn/87.6.1606
   Staels B, 2006, NAT MED, V12, P54, DOI 10.1038/nm0106-54
   Storch KF, 2002, NATURE, V417, P78, DOI 10.1038/nature744
   Takahashi JS, 2008, NAT REV GENET, V9, P764, DOI 10.1038/nrg2430
   Turek FW, 2005, SCIENCE, V308, P1043, DOI 10.1126/science.1108750
   Ulrich-Lai YM, 2006, AM J PHYSIOL-REG I, V290, pR1128, DOI 10.1152/ajpregu.00042.2003
   Woon PY, 2007, P NATL ACAD SCI USA, V104, P14412, DOI 10.1073/pnas.0703247104
   Yamamoto T, 2005, J BIOL CHEM, V280, P42036, DOI 10.1074/jbc.M509600200
   Yang ST, 2009, ENDOCRINOLOGY, V150, P2153, DOI 10.1210/en.2008-0705
   Yang XY, 2006, CELL, V126, P801, DOI 10.1016/j.cell.2006.06.050
   Yin L, 2007, SCIENCE, V318, P1786, DOI 10.1126/science.1150179
   Yoo SH, 2004, P NATL ACAD SCI USA, V101, P5339, DOI 10.1073/pnas.0308709101
NR 64
TC 311
Z9 352
U1 1
U2 45
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD MAY
PY 2010
VL 21
IS 5
BP 277
EP 286
DI 10.1016/j.tem.2009.12.011
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 609RK
UT WOS:000278674600003
PM 20106676
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Jaeschke, A
   Davis, RJ
AF Jaeschke, Anja
   Davis, Roger J.
TI Metabolic stress signaling mediated by mixed-lineage kinases
SO MOLECULAR CELL
LA English
DT Article
ID INDUCED INSULIN-RESISTANCE; FREE FATTY-ACIDS; RECEPTOR SUBSTRATE-1;
   TRANSDUCTION PATHWAY; MUSCLE-CELLS; MAP KINASES; IN-VIVO; B-RAF; JNK;
   ACTIVATION
AB Saturated free fatty acid (FFA) is a major source of metabolic stress that activates the c-Jun NH2-terminal kinase (JINK). This FFA-stimulated JNK pathway is relevant to hallmarks of metabolic syndrome, including insulin resistance. Here we used gene ablation studies in mice to demonstrate a central role for mixed-lineage protein kinases (MLK) in this signaling pathway. Saturated FFA causes protein kinase C (PKC)dependent activation of MLK3 that subsequently causes increased JNK activity by a mechanism that requires the MAP kinase kinases MKK4 and MKK7. Loss of PKC, MLK3, MKK4, or MKK7 expression prevents FIFA-stimulated JNK activation. Together, these data establish a signaling pathway that mediates effects of metabolic stress on insulin resistance.
C1 Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA.
   Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA.
C3 Howard Hughes Medical Institute; University of Massachusetts System;
   University of Massachusetts Worcester; University of Massachusetts
   System; University of Massachusetts Worcester
RP Davis, RJ (corresponding author), Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA.
EM roger.davis@umassmed.edu
OI Davis, Roger/0000-0002-0130-1652
FU NCI NIH HHS [R01 CA065861] Funding Source: Medline; NIDDK NIH HHS [R01
   DK063368] Funding Source: Medline
CR Aguirre V, 2002, J BIOL CHEM, V277, P1531, DOI 10.1074/jbc.M101521200
   Aguirre V, 2000, J BIOL CHEM, V275, P9047, DOI 10.1074/jbc.275.12.9047
   Arner P, 2002, DIABETES-METAB RES, V18, pS5, DOI 10.1002/dmrr.254
   Barthwal MK, 2003, J BIOL CHEM, V278, P3897, DOI 10.1074/jbc.M211598200
   Boden G, 2003, EXP CLIN ENDOCR DIAB, V111, P121, DOI 10.1055/s-2003-39781
   Boden Guenther, 2006, Curr Diab Rep, V6, P177, DOI 10.1007/s11892-006-0031-x
   Brancho D, 2005, MOL CELL BIOL, V25, P3670, DOI 10.1128/MCB.25.9.3670-3681.2005
   Chadee DN, 2006, P NATL ACAD SCI USA, V103, P4463, DOI 10.1073/pnas.0510651103
   Chadee DN, 2004, NAT CELL BIOL, V6, P770, DOI 10.1038/ncb1152
   Davis RJ, 2000, CELL, V103, P239, DOI 10.1016/S0092-8674(00)00116-1
   Delarue J, 2007, CURR OPIN CLIN NUTR, V10, P142, DOI 10.1097/MCO.0b013e328042ba90
   DERIJARD B, 1994, CELL, V76, P1025, DOI 10.1016/0092-8674(94)90380-8
   Dey D, 2006, MOL CELL ENDOCRINOL, V246, P60, DOI 10.1016/j.mce.2005.12.014
   Gallo KA, 2002, NAT REV MOL CELL BIO, V3, P663, DOI 10.1038/nrm906
   Gao ZG, 2004, MOL ENDOCRINOL, V18, P2024, DOI 10.1210/me.2003-0383
   Griffin ME, 1999, DIABETES, V48, P1270, DOI 10.2337/diabetes.48.6.1270
   Handley ME, 2007, INT J EXP PATHOL, V88, P111, DOI 10.1111/j.1365-2613.2007.00531.x
   Hashimoto S, 2001, AM J RESP CRIT CARE, V163, P152, DOI 10.1164/ajrccm.163.1.2005069
   Hirai S, 2006, J NEUROSCI, V26, P11992, DOI 10.1523/JNEUROSCI.2272-06.2006
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Kahn SE, 2006, NATURE, V444, P840, DOI 10.1038/nature05482
   Kesavan K, 2004, J CELL PHYSIOL, V199, P140, DOI 10.1002/jcp.10457
   Kim F, 2007, CIRC RES, V100, P1589, DOI 10.1161/CIRCRESAHA.106.142851
   Kim JK, 2006, CELL METAB, V4, P417, DOI 10.1016/j.cmet.2006.11.008
   Kim JK, 2004, J CLIN INVEST, V114, P823, DOI 10.1172/JCI200422230
   Kovacs P, 2005, BEST PRACT RES CL EN, V19, P625, DOI 10.1016/j.beem.2005.07.003
   Lam TKT, 2002, AM J PHYSIOL-ENDOC M, V283, pE682, DOI 10.1152/ajpendo.00038.2002
   Lawler S, 1998, CURR BIOL, V8, P1387, DOI 10.1016/S0960-9822(98)00019-0
   Lee YH, 2003, J BIOL CHEM, V278, P2896, DOI 10.1074/jbc.M208359200
   Leitges M, 2001, MOL CELL, V8, P771, DOI 10.1016/S1097-2765(01)00361-6
   Lopez-Bergami P, 2005, MOL CELL, V19, P309, DOI 10.1016/j.molcel.2005.06.025
   Malhi H, 2006, J BIOL CHEM, V281, P12093, DOI 10.1074/jbc.M510660200
   Maroney AC, 2001, J BIOL CHEM, V276, P25302, DOI 10.1074/jbc.M011601200
   Montell E, 2001, AM J PHYSIOL-ENDOC M, V280, pE229, DOI 10.1152/ajpendo.2001.280.2.E229
   Morino K, 2006, DIABETES, V55, pS9, DOI 10.2337/db06-S002
   Nguyen MTA, 2005, J BIOL CHEM, V280, P35361, DOI 10.1074/jbc.M504611200
   Poggi M, 2007, DIABETOLOGIA, V50, P1267, DOI 10.1007/s00125-007-0654-8
   Samuel VT, 2007, J CLIN INVEST, V117, P739, DOI 10.1172/JCI30400
   Saporito MS, 2002, PROGR MED CHEM, V40, P23, DOI 10.1016/S0079-6468(08)70081-X
   Sathyanarayana P, 2002, MOL CELL, V10, P1527, DOI 10.1016/S1097-2765(02)00734-7
   Sato S, 2005, NAT IMMUNOL, V6, P1087, DOI 10.1038/ni1255
   Schachter KA, 2006, J BIOL CHEM, V281, P19134, DOI 10.1074/jbc.M603324200
   Schattenberg JM, 2006, HEPATOLOGY, V43, P163, DOI 10.1002/hep.20999
   Schmitz-Peiffer C, 1999, J BIOL CHEM, V274, P24202, DOI 10.1074/jbc.274.34.24202
   Shi H, 2006, J CLIN INVEST, V116, P3015, DOI 10.1172/JCI28898
   Shim JH, 2005, GENE DEV, V19, P2668, DOI 10.1101/gad.1360605
   Shmueli O, 2003, CR BIOL, V326, P1067, DOI 10.1016/j.crvi.2003.09.012
   Solinas G, 2006, P NATL ACAD SCI USA, V103, P16454, DOI 10.1073/pnas.0607626103
   Song MJ, 2006, BIOCHEM BIOPH RES CO, V346, P739, DOI 10.1016/j.bbrc.2006.05.170
   Swenson KI, 2003, MOL BIOL CELL, V14, P156, DOI 10.1091/mbc.E02-02-0115
   Tobiume K, 2001, EMBO REP, V2, P222, DOI 10.1093/embo-reports/kve046
   Tournier C, 2001, GENE DEV, V15, P1419, DOI 10.1101/gad.888501
   Vacratsis PO, 2002, BIOCHEMISTRY-US, V41, P5613, DOI 10.1021/bi016075c
   Wagner ACC, 2000, AM J PHYSIOL-GASTR L, V278, pG165, DOI 10.1152/ajpgi.2000.278.1.G165
   Weston CR, 2007, CURR OPIN CELL BIOL, V19, P142, DOI 10.1016/j.ceb.2007.02.001
   White MF, 2006, CAN J PHYSIOL PHARM, V84, P725, DOI 10.1139/Y06-008
   Whitmarsh AJ, 2001, METHOD ENZYMOL, V332, P319
   Yu CL, 2002, J BIOL CHEM, V277, P50230, DOI 10.1074/jbc.M200958200
   Zhang L, 2005, MOL CELL BIOL, V25, P60, DOI 10.1128/MCB.25.1.60-65.2005
NR 59
TC 116
Z9 126
U1 0
U2 4
PU CELL PRESS
PI CAMBRIDGE
PA 1100 MASSACHUSETTS AVE, CAMBRIDGE, MA 02138 USA
SN 1097-2765
J9 MOL CELL
JI Mol. Cell
PD AUG 3
PY 2007
VL 27
IS 3
BP 498
EP 508
DI 10.1016/j.molcel.2007.07.008
PG 11
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 201HZ
UT WOS:000248823400013
PM 17679097
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Elovainio, M
   Kivimäki, M
   Viikari, J
   Raitakari, OT
   Keltikangas-Järvinen, L
   Pulkki-Råback, L
   Jokela, M
   Telama, R
AF Elovainio, Marko
   Kivimaki, Mika
   Viikari, Jorma
   Raitakari, Olli T.
   Keltikangas-Jarvinen, Liisa
   Pulkki-Raback, Laura
   Jokela, Markus
   Telama, Risto
TI Lipid Trajectories as Predictors of Depressive Symptoms: The Young Finns
   Study
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE depression; CHD; psychosocial factors; lipids
ID LOW SERUM-CHOLESTEROL; LATE-LIFE DEPRESSION; LOW HDL CHOLESTEROL;
   C-REACTIVE PROTEIN; MAJOR DEPRESSION; CARDIOVASCULAR RISK; METABOLIC
   SYNDROME; ASSOCIATION; CHILDHOOD; HYPOCHOLESTEROLEMIA
AB Objective: The aim of this study was to identify common trajectories of lipid levels across childhood and early adulthood life span. Design: The sample was a subpopulation of 824 young adults (3 to 9 years of age at baseline in 1980) of the ongoing population-based prospective Cardiovascular Risk in Young Finns Study. Lipid levels were determined in 1980, 1983, 1986, and 2001. Main Outcome Measures: Depressive symptoms were assessed using a modified version of Beck's Depression Inventory (Beck, 1967) in 1992 and 2001. Results: The 2 triglycerides trajectories (steeply vs. moderately increasing) were differently related to depressive symptoms in adulthood. The trajectory showing steep increase over time was associated with higher level of depressive symptoms (M 2.18, 95% Cl [2.08, 2.28] vs. 1.99, [1.95, 2.04]). This relationship persisted after adjustments for various risk factors. These triglycerides trajectories accounted for part of the association between high body mass index and depressive symptoms. Conclusion: A pattern of steeply increasing triglyceride levels throughout childhood and adulthood may be associated with increased the risk of depressive symptoms in adulthood. This pattern may also be one link between obesity and depressive symptoms.
C1 [Elovainio, Marko] Natl Inst Hlth & Welf, Helsinki 00271, Finland.
   [Elovainio, Marko; Keltikangas-Jarvinen, Liisa; Pulkki-Raback, Laura; Jokela, Markus] Univ Helsinki, Dept Psychol, FIN-00014 Helsinki, Finland.
   [Kivimaki, Mika] Univ Coll London, Dept Epidemiol & Publ Hlth, Helsinki, Finland.
   [Kivimaki, Mika] Finnish Inst Occupat Hlth, Helsinki, Finland.
   [Viikari, Jorma; Raitakari, Olli T.; Keltikangas-Jarvinen, Liisa] Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, SF-20500 Turku, Finland.
   [Viikari, Jorma; Raitakari, Olli T.] Univ Turku, Dept Clin Physiol, SF-20500 Turku, Finland.
   [Telama, Risto] Univ Jyvaskyla, LIKES, SF-40351 Jyvaskyla, Finland.
C3 Finland National Institute for Health & Welfare; University of Helsinki;
   Finnish Institute of Occupational Health; University of Turku;
   University of Turku; University of Jyvaskyla
RP Elovainio, M (corresponding author), Natl Inst Hlth & Welf, POB 30, Helsinki 00271, Finland.
EM marko.elovainio@thl.fi
RI Kivimaki, Mika/B-3607-2012; Raitakari, Olli/AAQ-7389-2021; Jokela,
   Markus/A-4669-2009
OI Elovainio, Marko/0000-0002-1401-1910; Kivimaki,
   Mika/0000-0002-4699-5627; Jokela, Markus/0000-0003-0117-0012
FU Signe and Ane Gyllenberg's Foundation; Academy of Finland [111056,
   209514, 123399, 123621, 117604, 7784, 210283, 128002]; Emil Aaltonen
   Foundation; Tampere University Hospital Medical Fund; Yrjo Jahnsson
   Foundation and Turku University; National Heart, Lung, and Blood
   Institute [R01HL036310-20A2]; National Institute on Aging
   [R01AG034454-01]; U.S. National Institutes of Health; Academy of
   Finland; BUPA Foundation, United Kingdom
FX This study was financially supported by the Signe and Ane Gyllenberg's
   Foundation (Liisa Keltikangas-Jarvinen), the Academy of Finland Grants
   111056, 209514, 123399 (Liisa Keltikangas-Jarvinen), 123621 (Laura
   Pulkki-Raback) and 117604 (Mika Kivimaki) and 7784 and 210283 (Olli T.
   Raitakari), Emil Aaltonen Foundation (Risto Telma), Tampere University
   Hospital Medical Fund (Risto Telma), the Yrjo Jahnsson Foundation and
   Turku University Hospital Medical Funds (Olli T. Raitakari and Jorma
   Viikari). Marko Elovainio was supported by the Work Environment Fund and
   Academy of Finland (128002). Mika Kivimaki was supported by the National
   Heart, Lung, and Blood Institute (R01HL036310-20A2) and the National
   Institute on Aging (R01AG034454-01) of the U.S. National Institutes of
   Health; by the Academy of Finland; and by the BUPA Foundation, United
   Kingdom.
CR Abdel-Maksoud M, 2008, J CARDIOVASC PHARM, V51, P331, DOI 10.1097/FJC.0b013e318165e2e7
   Äijänseppä S, 2002, INT J GERIATR PSYCH, V17, P629, DOI 10.1002/gps.666
   Almeida OP, 2007, AM J GERIAT PSYCHIAT, V15, P506, DOI 10.1097/01.JGP.0000246869.49892.77
   Barres BA, 2001, SCIENCE, V294, P1296, DOI 10.1126/science.1066724
   Beck AaronT., 1967, Depression
   Blazer DG, 2002, AM J GERIAT PSYCHIAT, V10, P515, DOI 10.1176/appi.ajgp.10.5.515
   Bollen KA, 2006, WILEY SER PROBAB ST, P1
   Borgherini G, 2002, ACTA PSYCHIAT SCAND, V105, P149, DOI 10.1034/j.1600-0447.2002.00495.x
   BROWN SL, 1995, ANN MED, V27, P141, DOI 10.3109/07853899509031950
   Bruce ML, 2002, BIOL PSYCHIAT, V52, P175, DOI 10.1016/S0006-3223(02)01410-5
   Buydens-Branchey L, 2000, PSYCHIAT RES, V93, P93, DOI 10.1016/S0165-1781(99)00126-2
   Chattopadhyay A, 2007, BIOCHEM BIOPH RES CO, V363, P800, DOI 10.1016/j.bbrc.2007.09.040
   Chattopadhyay A, 2007, BIOCHEM BIOPH RES CO, V354, P627, DOI 10.1016/j.bbrc.2007.01.032
   Chen CC, 2001, PSYCHIAT RES, V102, P153, DOI 10.1016/S0165-1781(01)00231-1
   Cortese S, 2009, J PEDIATR-US, V154, P86, DOI 10.1016/j.jpeds.2008.07.040
   Deisenhammer EA, 2004, PSYCHIAT RES, V121, P253, DOI 10.1016/j.psychres.2003.09.007
   Diebold K, 1998, PHARMACOPSYCHIATRY, V31, P60, DOI 10.1055/s-2007-979300
   Dimopoulos N, 2007, J GERIATR PSYCH NEUR, V20, P138, DOI 10.1177/0891988707301867
   Elovainio M, 2008, NEUROPSYCHOBIOLOGY, V58, P91, DOI 10.1159/000162355
   Elovainio M, 2006, PSYCHOL MED, V36, P797, DOI 10.1017/S0033291706007574
   ENGELBERG H, 1992, LANCET, V339, P727, DOI 10.1016/0140-6736(92)90609-7
   Ergün UGÖ, 2004, INT J GERIATR PSYCH, V19, P291, DOI 10.1002/gps.1078
   Fischer P, 2006, MOL PSYCHIATR, V11, P707, DOI 10.1038/sj.mp.4001837
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   GLUECK CJ, 1994, AM J MED SCI, V308, P218
   GLUECK CJ, 1994, PEDIATR RES, V35, P602, DOI 10.1203/00006450-199405000-00013
   GOLDSTEIN H, 1994, STAT MED, V13, P1643, DOI 10.1002/sim.4780131605
   Horsten M, 1997, PSYCHOSOM MED, V59, P521, DOI 10.1097/00006842-199709000-00009
   Jones BL, 2001, SOCIOL METHOD RES, V29, P374, DOI 10.1177/0049124101029003005
   KENDLER KS, 1993, PSYCHOL MED, V23, P361, DOI 10.1017/S0033291700028464
   Kessler RC, 1997, J AFFECT DISORDERS, V45, P19, DOI 10.1016/S0165-0327(97)00056-6
   Kim JM, 2006, BRIT J PSYCHIAT, V189, P26, DOI 10.1192/bjp.bp.105.015032
   Kim JM, 2004, BRIT J PSYCHIAT, V185, P102, DOI 10.1192/bjp.185.2.102
   Kim YK, 2004, J AFFECT DISORDERS, V81, P161, DOI 10.1016/S0165-0327(03)00166-6
   Kivimäki M, 2006, ANN EPIDEMIOL, V16, P737, DOI 10.1016/j.annepidem.2006.01.004
   Kivimäki M, 2009, BMJ-BRIT MED J, V339, DOI 10.1136/bmj.b3765
   Lehto SM, 2008, PROG NEURO-PSYCHOPH, V32, P1557, DOI 10.1016/j.pnpbp.2008.05.021
   Maes M, 1999, ADV EXP MED BIOL, V461, P25
   Marin TJ, 2008, PSYCHOSOM MED, V70, P152, DOI 10.1097/PSY.0b013e3181647d16
   Partonen T, 1999, BRIT J PSYCHIAT, V175, P259, DOI 10.1192/bjp.175.3.259
   Pulkki-Råback L, 2009, HEALTH PSYCHOL, V28, P108, DOI 10.1037/a0012646
   Raitakari OT, 2008, INT J EPIDEMIOL, V37, P1220, DOI 10.1093/ije/dym225
   Sagud M, 2009, PSYCHIAT RES, V168, P218, DOI 10.1016/j.psychres.2008.06.048
   Shin JY, 2008, ANN BEHAV MED, V36, P33, DOI 10.1007/s12160-008-9045-8
   Terao T, 2000, ACTA PSYCHIAT SCAND, V101, P231
   Toker S, 2005, J OCCUP HEALTH PSYCH, V10, P344, DOI 10.1037/1076-8998.10.4.344
   Troisi A, 2009, NEUROSCI BIOBEHAV R, V33, P125, DOI 10.1016/j.neubiorev.2008.09.003
   Virtanen M, 2008, AM J PSYCHIAT, V165, P1482, DOI 10.1176/appi.ajp.2008.07121929
   Vogelzangs N, 2007, PSYCHONEUROENDOCRINO, V32, P151, DOI 10.1016/j.psyneuen.2006.11.009
NR 49
TC 24
Z9 24
U1 0
U2 9
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD MAY
PY 2010
VL 29
IS 3
BP 237
EP 245
DI 10.1037/a0018875
PG 9
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA 604TS
UT WOS:000278302000001
PM 20496976
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Iraj, B
   Taheri, N
   Amini, M
   Amini, P
   Aminorroaya, A
AF Iraj, Bijan
   Taheri, Nader
   Amini, Massoud
   Amini, Payvand
   Aminorroaya, Ashraf
TI Should the first degree relatives of type 2 diabetic patients with
   isolated impaired fasting glucose be considered for a diabetes primary
   prevention program?
SO JOURNAL OF RESEARCH IN MEDICAL SCIENCES
LA English
DT Article
DE Prediabetic States Diabetes Mellitus; Type II; Oral Glucose Tolerance
   Test; Primary Prevention; Dyslipidemia; Risk Factor; Iran
ID OXIDATIVE STRESS; GLUTATHIONE-PEROXIDASE; SUPEROXIDE-DISMUTASE;
   ANTIOXIDANT ENZYMES; BY-PRODUCTS; HYPERTENSION; CATALASE; AGE;
   EXPRESSION; DISEASE
AB BACKGROUND The aim of this study is to investigate the need for diabetes primary prevention program in isolated impaired fasting glucose (i-IFG) of the first degree relatives of type 2 diabetics
   METHODS In a cross sectional study, 793 individuals with prediabetes [543 with i-IFG and 250 with isolated impaired glucose tolerance (i-IGT)] who were the first degree relatives of type 2 diabetic patients were enrolled Isolated IFG was considered as fasting plasma glucose between 100-125 mg/dl and 2 hour plasma glucose < 140 mg/dl and isolated JOT as FPG < 100 mg/dl and 2 hour plasma glucose between 140-199 mg/dl during an overnight fasting 75 g oral glucose tolerance test Mean of the age, weight, waist circumference, body mass index systolic and diastolic blood pressure, plasma glucose, HbA1C, and lipid profile were compared between two groups (i-IFG and i-IGT) The prevalence of cardiometabolic risk factors (BMI >= 25 kg/m2 hypertension cholesterol >= 200 mg/dl LDL-C >= 100 mg/dl HDL-C <= 40 mg/dl, and triglyceride >= 150 mg/dl) adjusted by age, sex and BMI were compared
   RESULTS The prevalence of cardiometabolic risk factors is higher in i-IFG group than i-IGT The mean level of LDL-C is significantly higher in i-IFG than i-IGT group
   CONCLUSIONS First degree relatives of T2DM with isolated impaired fasting glucose should probably be included in the primary preventive program for diabetes However, longitudinal cohort study is required to show high progression of i-IFG to T2DM
C1 [Iraj, Bijan; Taheri, Nader; Amini, Massoud; Amini, Payvand; Aminorroaya, Ashraf] Isfahan Univ Med Sci, Isfahan Endocrine & Metab Res Ctr, Esfahan, Iran.
C3 Isfahan University of Medical Sciences
RP Aminorroaya, A (corresponding author), Isfahan Univ Med Sci, Isfahan Endocrine & Metab Res Ctr, Esfahan, Iran.
RI Janghorbani, Mohsen/A-2330-2010; Amini, Massoud/C-5340-2013;
   Aminorroaya, Ashraf/B-9240-2013; iraj, bijan/E-6662-2012
OI Aminorroaya, Ashraf/0000-0002-7550-1198; Amini,
   Massoud/0000-0003-4134-0960; iraj, bijan/0000-0003-0561-408X
CR AEBI H, 1984, METHOD ENZYMOL, V105, P121
   AMIRKHIZI F, 2007, J TEHRAN U HEART CTR, V2, P137
   Chaves FJ, 2007, AM J HYPERTENS, V20, P62, DOI 10.1016/j.amjhyper.2006.06.006
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   GOTH L, 1991, CLIN CHIM ACTA, V196, P143, DOI 10.1016/0009-8981(91)90067-M
   Harrison DG, 2007, J AM SOC HYPERTENS, V1, P30, DOI 10.1016/j.jash.2006.11.006
   HARTFORD M, 1985, HYPERTENSION, V7, P97, DOI 10.1161/01.HYP.7.1.97
   Isler M, 2002, CROAT MED J, V43, P16
   JI LL, 1991, AM J PHYSIOL, V261, pR386, DOI 10.1152/ajpregu.1991.261.2.R386
   Katsouyanni K, 1997, INT J EPIDEMIOL, V26, pS118, DOI 10.1093/ije/26.suppl_1.S118
   Lacy F, 2000, HYPERTENSION, V36, P878, DOI 10.1161/01.HYP.36.5.878
   Lenfant C, 2003, HYPERTENSION, V41, P1178, DOI 10.1161/01.HYP.0000075790.33892.AE
   MAGGI E, 1993, J HYPERTENS, V11, P1103, DOI 10.1097/00004872-199310000-00015
   MCCORD JM, 1993, CLIN BIOCHEM, V26, P351, DOI 10.1016/0009-9120(93)90111-I
   Medina-Lezama J, 2007, J AM SOC HYPERTENS, V1, P216, DOI 10.1016/j.jash.2007.02.003
   MICHIELS C, 1994, FREE RADICAL BIO MED, V17, P235, DOI 10.1016/0891-5849(94)90079-5
   NAKAZONO K, 1991, P NATL ACAD SCI USA, V88, P10045, DOI 10.1073/pnas.88.22.10045
   PAGLIA DE, 1967, J LAB CLIN MED, V70, P158
   PALMER A, 1995, J HUM HYPERTENS, V9, P695
   Raij L, 1998, HYPERTENSION, V31, P189, DOI 10.1161/01.HYP.31.1.189
   RAO G, 1990, MECH AGEING DEV, V53, P49, DOI 10.1016/0047-6374(90)90033-C
   Redón J, 2003, HYPERTENSION, V41, P1096, DOI 10.1161/01.HYP.0000068370.21009.38
   Russo C, 1998, J HYPERTENS, V16, P1267, DOI 10.1097/00004872-199816090-00007
   Simic DV, 2006, J HUM HYPERTENS, V20, P149, DOI 10.1038/sj.jhh.1001945
   Taddei S, 2001, HYPERTENSION, V38, P274, DOI 10.1161/01.HYP.38.2.274
   Touyz RM, 2004, HYPERTENSION, V44, P248, DOI 10.1161/01.HYP.0000138070.47616.9d
   Touyz RM, 2003, CLIN EXP PHARMACOL P, V30, P860, DOI 10.1046/j.1440-1681.2003.03930.x
   Tsay HJ, 2000, J BIOMED SCI, V7, P466
   UCHIDA K, 1994, J BIOL CHEM, V269, P2405
   Wassmann S, 2004, HYPERTENSION, V44, P381, DOI 10.1161/01.HYP.0000142232.29764.a7
   2000, SWITZERLAND WHO TECH, V894, P1
NR 31
TC 7
Z9 8
U1 0
U2 1
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 1735-1995
EI 1735-7136
J9 J RES MED SCI
JI J. Res. Med. Sci.
PD SEP-OCT
PY 2010
VL 15
IS 5
BP 264
EP 278
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 688QQ
UT WOS:000284866900004
PM 21526094
DA 2025-06-11
ER

PT J
AU Shrestha, S
   Irvin, MR
   Grunfeld, C
   Arnett, DK
AF Shrestha, Sadeep
   Irvin, Marguerite R.
   Grunfeld, Carl
   Arnett, Donna K.
TI HIV, Inflammation, and Calcium in Atherosclerosis
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Review
DE atherosclerosis; calcium; endoplasmic reticulum stress; HIV;
   inflammation
ID TOLL-LIKE RECEPTORS; ENDOPLASMIC-RETICULUM STRESS; CARDIOVASCULAR
   RISK-FACTORS; REGIONAL ADIPOSE-TISSUE; CORONARY-HEART-DISEASE;
   ANTIRETROVIRAL THERAPY; PROTEASE INHIBITORS; ADHESION MOLECULES;
   LIPOPROTEIN LEVELS; METABOLIC SYNDROME
AB Atherosclerosis is consistently higher among the HIV-positive patients, with or without treatment, than among the HIV-negative population. Risk factors linked to atherosclerotic cardiovascular disease in HIV infection are both traditional and HIV specific although the underlying mechanisms are not fully delineated. Three key sequential biological processes are postulated to accelerate progression of atherosclerosis in the context of HIV: (1) inflammation, (2) transformation of monocytes to macrophages and then foam cells, and (3) apoptosis of foam cells leading to plaque development through Ca2+-dependent endoplasmic reticulum stress. These proatherogenic mechanisms are further affected when HIV interacts with the genes involved in various phases within this network.
C1 [Shrestha, Sadeep; Irvin, Marguerite R.; Arnett, Donna K.] Univ Alabama Birmingham, Dept Epidemiol, Sch Publ Hlth, Birmingham, AL 35294 USA.
   [Grunfeld, Carl] Univ Calif San Francisco, Div Endocrinol & Metab, San Francisco, CA 94143 USA.
   [Grunfeld, Carl] Vet Affairs Med Ctr, San Francisco, CA 94121 USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of California System; University of California San Francisco;
   US Department of Veterans Affairs; Veterans Health Administration (VHA)
RP Shrestha, S (corresponding author), Univ Alabama Birmingham, Dept Epidemiol, 1665 Univ Blvd,RPHB Room 217L, Birmingham, AL 35294 USA.
EM sshrestha@uab.edu
OI Arnett, Donna/0000-0003-2219-657X
CR Aiello RJ, 2002, ARTERIOSCL THROM VAS, V22, P630, DOI 10.1161/01.ATV.0000014804.35824.DA
   Alonso-Villaverde C, 2004, CIRCULATION, V110, P2204, DOI 10.1161/01.CIR.0000143835.95029.7D
   Ameziane N, 2003, ARTERIOSCL THROM VAS, V23, pE61, DOI 10.1161/01.ATV.0000101191.92392.1D
   Arbour NC, 2000, NAT GENET, V25, P187, DOI 10.1038/76048
   Björkbacka H, 2004, NAT MED, V10, P416, DOI 10.1038/nm1008
   Brenchley JM, 2006, NAT MED, V12, P1365, DOI 10.1038/nm1511
   Caligiuri G, 2003, MOL MED, V9, P10, DOI 10.1007/BF03402102
   Campbell SM, 2002, AIDS, V16, P2253, DOI 10.1097/00002030-200211220-00004
   Canault M, 2008, J PATHOL, V214, P574, DOI 10.1002/path.2305
   Carr A, 1999, LANCET, V353, P2093, DOI 10.1016/S0140-6736(98)08468-2
   Chomarat P, 2000, NAT IMMUNOL, V1, P510, DOI 10.1038/82763
   Cole JE, 2011, P NATL ACAD SCI USA, V108, P2372, DOI 10.1073/pnas.1018515108
   Cooper ME, 2001, AM J HYPERTENS, V14, P475, DOI 10.1016/S0895-7061(00)01323-6
   Crowe SM, 2010, J LEUKOCYTE BIOL, V87, P589, DOI 10.1189/jlb.0809580
   Currier J, 2008, JAIDS-J ACQ IMM DEF, V48, P35, DOI 10.1097/QAI.0b013e318164227f
   Currier Judith S, 2008, Circulation, V118, pe29, DOI 10.1161/CIRCULATIONAHA.107.189624
   Curtiss LK, 2009, J LIPID RES, V50, pS340, DOI 10.1194/jlr.R800056-JLR200
   David AR, 2010, LANCET, V375, P718, DOI 10.1016/S0140-6736(10)60294-2
   Dean M, 1996, SCIENCE, V273, P1856, DOI 10.1126/science.273.5283.1856
   Dever LL, 2000, ANN PHARMACOTHER, V34, P580
   Dickhout JG, 2007, ANTIOXID REDOX SIGN, V9, P1863, DOI 10.1089/ars.2007.1780
   Dinarello CA, 2011, EUR J IMMUNOL, V41, P1203, DOI 10.1002/eji.201141550
   Drechsler M, 2013, J INNATE IMMUN, V5, P358, DOI 10.1159/000348795
   Dressman J, 2003, J CLIN INVEST, V111, P389, DOI 10.1172/JCI200316261
   Effros RB, 2008, CLIN INFECT DIS, V47, P542, DOI 10.1086/590150
   El-Sadr WM, 2008, ANN INTERN MED, V149, P289, DOI 10.7326/0003-4819-149-5-200809020-00003
   El-Sadr WM, 2006, NEW ENGL J MED, V355, P2283, DOI 10.1056/NEJMoa062360
   Erdmann F, 2011, EMBO J, V30, P17, DOI 10.1038/emboj.2010.284
   Falck-Hansen M, 2013, INT J MOL SCI, V14, P14008, DOI 10.3390/ijms140714008
   Feingold KR, 2008, ATHEROSCLEROSIS, V199, P19, DOI 10.1016/j.atherosclerosis.2007.10.007
   Feingold KR, 2012, J LEUKOCYTE BIOL, V92, P829, DOI 10.1189/jlb.1111537
   Feingold KR, 2011, J LIPID RES, V52, P1, DOI 10.1194/jlr.E012138
   Feingold KR, 2010, J LIPID RES, V51, P682, DOI 10.1194/jlr.E005454
   Feng B, 2003, NAT CELL BIOL, V5, P781, DOI 10.1038/ncb1035
   Foti M, 1999, J BIOL CHEM, V274, P34765, DOI 10.1074/jbc.274.49.34765
   Frostegård J, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-117
   Galkina E, 2007, ARTERIOSCL THROM VAS, V27, P2292, DOI 10.1161/ATVBAHA.107.149179
   Grunfeld Carl, 2008, Circulation, V118, pe20, DOI 10.1161/CIRCULATIONAHA.107.189623
   Gui T, 2012, MEDIAT INFLAMM, V2012, DOI 10.1155/2012/693083
   Hansson GK, 2005, NEW ENGL J MED, V352, P1685, DOI 10.1056/NEJMra043430
   Higashimori M, 2011, ARTERIOSCL THROM VAS, V31, P50, DOI 10.1161/ATVBAHA.110.210971
   Hodgkinson CP, 2011, THESCIENTIFICWORLDJO, V11, P437, DOI 10.1100/tsw.2011.36
   Hotamisligil GS, 2010, NAT MED, V16, P396, DOI 10.1038/nm0410-396
   Jones KL, 2011, BRIT J PHARMACOL, V162, P1453, DOI 10.1111/j.1476-5381.2010.01147.x
   Khovidhunkit W, 2004, J LIPID RES, V45, P1169, DOI 10.1194/jlr.R300019-JLR200
   Kiechl S, 2002, NEW ENGL J MED, V347, P185, DOI 10.1056/NEJMoa012673
   Klein D, 2002, J ACQ IMMUN DEF SYND, V30, P471, DOI 10.1097/00126334-200208150-00002
   Kuller LH, 2008, PLOS MED, V5, P1496, DOI 10.1371/journal.pmed.0050203
   Lekakis J, 2008, CLIN SCI, V115, P189, DOI 10.1042/CS20070353
   Ley K, 2011, ARTERIOSCL THROM VAS, V31, P1506, DOI 10.1161/ATVBAHA.110.221127
   Libby P, 2011, NATURE, V473, P317, DOI 10.1038/nature10146
   Lo J, 2012, J INFECT DIS, V205, pS368, DOI 10.1093/infdis/jis201
   Lorenz MW, 2008, ATHEROSCLEROSIS, V196, P720, DOI 10.1016/j.atherosclerosis.2006.12.022
   Mallal SA, 2000, AIDS, V14, P1309, DOI 10.1097/00002030-200007070-00002
   Maniar A, 2013, EUR J PREV CARDIOL, V20, P720, DOI 10.1177/2047487312447843
   Mekahli D., 2011, Cold Spring Harb Perspect Biol, V3, P1
   Mercié P, 2005, HIV MED, V6, P380, DOI 10.1111/j.1468-1293.2005.00324.x
   Mizuno Y, 2011, J ATHEROSCLER THROMB, V18, P351, DOI 10.5551/jat.7591
   Mujawar Z, 2006, PLOS BIOL, V4, P1970, DOI 10.1371/journal.pbio.0040365
   Murphy WA, 2003, RADIOLOGY, V226, P614, DOI 10.1148/radiol.2263020338
   Nicolaou G, 2010, CURR OPIN LIPIDOL, V21, P427, DOI 10.1097/MOL.0b013e32833cacd5
   Norman JP, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003731
   O'Neill LAJ, 2013, NAT REV IMMUNOL, V13, P453, DOI 10.1038/nri3446
   Oda K, 2007, HUM MOL GENET, V16, P592, DOI 10.1093/hmg/ddl483
   Ono A, 2001, P NATL ACAD SCI USA, V98, P13925, DOI 10.1073/pnas.241320298
   Oyadomari S, 2004, CELL DEATH DIFFER, V11, P381, DOI 10.1038/sj.cdd.4401373
   Paladugu R, 2003, J VASC SURG, V38, P549, DOI 10.1016/S0741-5214(03)00770-5
   Park IW, 2001, BLOOD, V97, P352, DOI 10.1182/blood.V97.2.352
   Periard D, 2008, CLIN INFECT DIS, V46, P761, DOI 10.1086/527564
   Plank MJ, 2006, PROG BIOPHYS MOL BIO, V91, P287, DOI 10.1016/j.pbiomolbio.2005.07.005
   Rao RM, 2007, CIRC RES, V101, P234, DOI 10.1161/CIRCRESAHA.107.151860b
   Reingold JS, 2008, JAIDS-J ACQ IMM DEF, V48, P142, DOI 10.1097/QAI.0b013e3181685727
   RIECKMANN P, 1991, J IMMUNOL, V147, P2922
   Robertson AKL, 2003, J CLIN INVEST, V112, P1342, DOI 10.1172/JCI200318607
   Sabin CA, 2008, CURR OPIN HIV AIDS, V3, P214, DOI 10.1097/COH.0b013e3282f6a613
   Shrestha S, 2012, AIDS, V26, P1571, DOI 10.1097/QAD.0b013e328355359f
   Shrestha S, 2010, AIDS, V24, P583, DOI 10.1097/QAD.0b013e3283353c9e
   Skålén K, 2002, NATURE, V417, P750, DOI 10.1038/nature00804
   SMITH JD, 1995, P NATL ACAD SCI USA, V92, P8264, DOI 10.1073/pnas.92.18.8264
   Söderquist B, 1999, CLIN EXP IMMUNOL, V118, P408
   Sorrentino V, 2003, FRONT BIOSCI-LANDMRK, V8, pD176, DOI 10.2741/855
   Souza SJ, 2013, REV ASSOC MED BRAS, V59, P186, DOI [10.1016/j.ramb.2012.11.003, 10.1016/S2255-4823(13)70454-5]
   Spirig R, 2012, CARDIOL RES PRACT, V2012, DOI 10.1155/2012/181394
   Stone S F, 2002, HIV Med, V3, P21, DOI 10.1046/j.1464-2662.2001.00096.x
   Swingler S, 1999, NAT MED, V5, P997, DOI 10.1038/12433
   Tabas I, 2010, CIRC RES, V107, P839, DOI 10.1161/CIRCRESAHA.110.224766
   Tabas I, 2009, ANN NY ACAD SCI, V1173, pE40, DOI 10.1111/j.1749-6632.2009.04957.x
   Tedgui A, 2006, PHYSIOL REV, V86, P515, DOI 10.1152/physrev.00024.2005
   Thiébaut F, 2005, AIDS, V19, P729, DOI 10.1097/01.aids.0000166097.46940.35
   Torriani FJ, 2008, J AM COLL CARDIOL, V52, P569, DOI 10.1016/j.jacc.2008.04.049
   Triant VA, 2007, J CLIN ENDOCR METAB, V92, P2506, DOI 10.1210/jc.2006-2190
   van 't Wout AB, 2005, J VIROL, V79, P10053, DOI 10.1128/JVI.79.15.10053-10058.2005
   Walli R, 1998, ANN INTERN MED, V129, P837, DOI 10.7326/0003-4819-129-10-199811150-00022
   Wohl D, 2008, JAIDS-J ACQ IMM DEF, V48, P44, DOI 10.1097/QAI.0b013e31816d9ba1
   Wolf K, 2002, J INFECT DIS, V185, P456, DOI 10.1086/338572
   Young J, 2005, ANTIVIR THER, V10, P585
   Yuan ZB, 2009, AM J PHYSIOL-HEART C, V296, pH1336, DOI 10.1152/ajpheart.01095.2008
   Yudkin JS, 2004, METABOLISM, V53, P852, DOI 10.1016/j.metabol.2004.02.004
   Zheng YH, 2003, P NATL ACAD SCI USA, V100, P8460, DOI 10.1073/pnas.1437453100
   Zirlik A, 2007, ARTERIOSCL THROM VAS, V27, P2043, DOI 10.1161/ATVBAHA.107.149484
NR 100
TC 52
Z9 59
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD FEB
PY 2014
VL 34
IS 2
BP 244
EP 250
DI 10.1161/ATVBAHA.113.302191
PG 7
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA AG7OL
UT WOS:000335607300008
PM 24265418
OA Bronze
DA 2025-06-11
ER

PT J
AU Sparic, R
   Andjic, M
   Vergara, D
   Morciano, A
   D'Oria, O
   Baldini, GM
   Malvasi, A
   Tinelli, A
AF Sparic, Radmila
   Andjic, Mladen
   Vergara, Daniele
   Morciano, Andrea
   D'Oria, Ottavia
   Baldini, Giorgio Maria
   Malvasi, Antonio
   Tinelli, Andrea
TI PCOS and vitamin D: a clinical appraisal
SO ARCHIVES OF GYNECOLOGY AND OBSTETRICS
LA English
DT Review
DE PCOS; Vitamin D; Metabolic syndrome; Endocrine disorders; Insulin
   resistance
AB PurposePolycystic ovary syndrome (PCOS) is the most common endocrine-reproductive disease linked not just to infertility but also to serious comorbidities. There is a reported association between low vitamin D levels and multiple health conditions including PCOS. This narrative review aims to analyze the role of vitamin D in PCOS development, use of the vitamin D in the treatment of PCOS, and the molecular basis of these observations.MethodsA Medline and PubMed research was performed, during the years 1990-2023, using a combination of keywords on such topic. According to the author's evaluation and target, papers were identified and included for a narrative review.ResultsThere are associations between lower levels of vitamin D and PCOS, as well as with insulin resistance, metabolic syndrome, hyperandrogenemia, metabolic and endocrine disorders as well as the onset of oxidative stress and pro-inflammatory milieu, in PCOS women.ConclusionVitamin D has a role in pathologic changes linked to PCOS. Molecular and clinical investigations which give new information about the role of vitamin D in the development of PCOS and related endocrine and metabolic disturbance are further needed.
C1 [Sparic, Radmila; Andjic, Mladen] Univ Clin Ctr Serbia, Clin Gynecol & Obstet, Belgrade 11000, Serbia.
   [Sparic, Radmila] Univ Belgrade, Fac Med, Belgrade 11000, Serbia.
   [Vergara, Daniele] Univ Salento, Dept Biol & Environm Sci & Technol DiSTeBA, Str Prov Lecce Monteroni, I-73100 Lecce, Italy.
   [Morciano, Andrea] Pia Fdn Card G Panico, Dept Gynecol & Obstet, Lecce, Italy.
   [D'Oria, Ottavia] Dept Med & Surg Sci & Translat Med, Translat Med & Oncol, Rome, Italy.
   [D'Oria, Ottavia] Sapienza Univ, Dept Gynecol Obstetr & Urol Sci, Rome, Italy.
   [Baldini, Giorgio Maria] MOMO Ferti LIFE IVF Ctr, Bisceglie, Italy.
   [Malvasi, Antonio] Univ Bari, Dept Biomed Sci & Human Oncol, I-70121 Bari, Italy.
   [Tinelli, Andrea] Veris delli Ponti Hosp, Dept Obstet & Gynecol, Via Giuseppina delli Ponti, I-73020 Lecce, Italy.
   [Tinelli, Andrea] Veris delli Ponti Hosp, CERICSAL Ctr Ric Clin SALentino, Via Giuseppina delli Ponti, I-73020 Lecce, Italy.
C3 Clinical Centre of Serbia; University of Belgrade; University of
   Salento; Sapienza University Rome; Universita degli Studi di Bari Aldo
   Moro
RP Tinelli, A (corresponding author), Veris delli Ponti Hosp, Dept Obstet & Gynecol, Via Giuseppina delli Ponti, I-73020 Lecce, Italy.; Tinelli, A (corresponding author), Veris delli Ponti Hosp, CERICSAL Ctr Ric Clin SALentino, Via Giuseppina delli Ponti, I-73020 Lecce, Italy.
EM andreatinelli@gmail.com
RI D'Oria, Ottavia/HJY-0040-2023; Morciano, Andrea/GPS-9104-2022; Vergara,
   Daniele/K-3831-2014; Tinelli, Andrea/B-6811-2014
OI Vergara, Daniele/0000-0002-2396-7674; Morciano,
   Andrea/0000-0001-5420-4277; Tinelli, Andrea/0000-0001-8426-8490;
   Malvasi, Antonio/0000-0001-6940-7608; Andic, Mladen/0000-0002-6312-5404;
   Baldini, Giorgio Maria/0000-0002-5061-8007; D'Oria,
   Ottavia/0000-0002-3482-1523
CR Arslan E, 2019, GEBURTSH FRAUENHEILK, V79, P723, DOI 10.1055/a-0871-6831
   Azadi-Yazdi M, 2017, HORM METAB RES, V49, P174, DOI 10.1055/s-0043-103573
   Azziz R, 2018, OBSTET GYNECOL, V132, P321, DOI 10.1097/AOG.0000000000002698
   Bednarska S, 2017, ADV CLIN EXP MED, V26, P359, DOI 10.17219/acem/59380
   Bianchi L, 2016, EXPERT REV MOL MED, V18, DOI 10.1017/erm.2016.4
   Bindayel MA, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.611351
   Bostanci EI, 2018, J PEDIATR ADOL GYNEC, V31, P270, DOI 10.1016/j.jpag.2017.07.008
   Bouillon R, 2022, NAT REV ENDOCRINOL, V18, P96, DOI 10.1038/s41574-021-00593-z
   Butts SF, 2019, J CLIN ENDOCR METAB, V104, P369, DOI 10.1210/jc.2018-00750
   Contreras-Bolivar V, 2021, NUTRIENTS, V13, DOI 10.3390/nu13103491
   Dastorani M, 2018, REPROD BIOL ENDOCRIN, V16, DOI 10.1186/s12958-018-0413-3
   Dawood Ayman Shehata, 2018, J Hum Reprod Sci, V11, P343, DOI [10.4103/jhrs.jhrs_40_18, 10.4103/jhrs.JHRS_40_18]
   Diamanti-Kandarakis E, 2008, CLIN ENDOCRINOL, V69, P634, DOI 10.1111/j.1365-2265.2008.03247.x
   Echchgadda I, 2004, MOL PHARMACOL, V65, P720, DOI 10.1124/mol.65.3.720
   Fang F, 2017, COMPLEMENT THER CLIN, V26, P53, DOI 10.1016/j.ctcp.2016.11.008
   Fichera M, 2020, INT J FOOD SCI NUTR, V71, P276, DOI 10.1080/09637486.2019.1661978
   Figurová J, 2017, HORM MOL BIOL CLIN I, V29, P85, DOI 10.1515/hmbci-2016-0039
   Franasiak JM, 2017, CURR OPIN OBSTET GYN, V29, P189, DOI 10.1097/GCO.0000000000000375
   Garg D, 2017, J ASSIST REPROD GEN, V34, P1507, DOI 10.1007/s10815-017-1011-6
   Gokosmanoglu F, 2020, AFR HEALTH SCI, V20, P1880, DOI 10.4314/ahs.v20i4.45
   Grundmann M, 2011, REPROD BIOL ENDOCRIN, V9, DOI 10.1186/1477-7827-9-146
   Güngör ND, 2023, EUR REV MED PHARMACO, V27, P179, DOI 10.26355/eurrev_202301_30870
   Hasan Hayder A, 2023, Endocr Pract, V29, P235, DOI 10.1016/j.eprac.2023.01.005
   He CL, 2015, NUTRIENTS, V7, P4555, DOI 10.3390/nu7064555
   Irani M, 2014, FERTIL STERIL, V102, P460, DOI 10.1016/j.fertnstert.2014.04.046
   Javed Z, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010188
   Jia XZ, 2015, J OBSTET GYNAECOL RE, V41, P1791, DOI 10.1111/jog.12793
   Kjalarsdottir L, 2019, J STEROID BIOCHEM, V185, P17, DOI 10.1016/j.jsbmb.2018.07.004
   Krul-Poel YHM, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204748
   Lagowska K, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111637
   Leung PS, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030147
   Liang F, 2019, ADV CLIN EXP MED, V28, P255, DOI 10.17219/acem/85882
   Maestro B, 2003, J STEROID BIOCHEM, V84, P223, DOI 10.1016/S0960-0760(03)00032-3
   Maestro B, 2002, CELL BIOCHEM FUNCT, V20, P227, DOI 10.1002/cbf.951
   Maktabi M, 2017, HORM METAB RES, V49, P493, DOI 10.1055/s-0043-107242
   Malm G, 2023, PLOS ONE, V18, DOI 10.1371/journal.pone.0281234
   Masjedi F, 2020, J STEROID BIOCHEM, V197, DOI 10.1016/j.jsbmb.2019.105521
   Merhi Z, 2018, MOL HUM REPROD, V24, P318, DOI 10.1093/molehr/gay014
   Miao CY, 2020, EXP THER MED, V19, P2641, DOI 10.3892/etm.2020.8525
   Michael W, 2022, J AM BOARD FAM MED, V35, P1217, DOI 10.3122/jabfm.2022.220115R1
   Milner R D, 1967, Diabetologia, V3, P47, DOI 10.1007/BF01269910
   Morgante G, 2022, J CLIN MED, V11, DOI 10.3390/jcm11154509
   Nandi E R, 2023, Mymensingh Med J, V32, P125
   Niu YM, 2019, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01902
   Norman AW, 2002, MOL CELL ENDOCRINOL, V197, P1, DOI 10.1016/S0303-7207(02)00273-3
   Ozyurt R, 2022, TAIWAN J OBSTET GYNE, V61, P620, DOI 10.1016/j.tjog.2022.03.041
   Patel S, 2018, J STEROID BIOCHEM, V182, P27, DOI 10.1016/j.jsbmb.2018.04.008
   Patten RK, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-29503-1
   Peng G, 2023, REPROD BIOL ENDOCRIN, V21, DOI 10.1186/s12958-023-01075-9
   Pergialiotis V, 2017, INT J CLIN PRACT, V71, DOI 10.1111/ijcp.12957
   Razavi M, 2016, HORM METAB RES, V48, P446, DOI 10.1055/s-0042-104060
   Sadeghi HM, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020583
   Santos BR, 2018, REPROD BIOL ENDOCRIN, V16, DOI 10.1186/s12958-018-0355-9
   Shahmoradi A, 2022, INT J REPROD BIOMED, V20, P433, DOI 10.18502/ijrm.v20i6.11439
   Shang YJ, 2020, J CLIN ENDOCR METAB, V105, DOI 10.1210/clinem/dgaa425
   Shi XY, 2019, BMC MED GENET, V20, DOI 10.1186/s12881-019-0763-5
   Simpson S, 2020, REPROD BIOL ENDOCRIN, V18, DOI 10.1186/s12958-020-00676-y
   Trummer C, 2019, EUR J NUTR, V58, P2019, DOI 10.1007/s00394-018-1760-8
   Usluogullari B, 2015, J OVARIAN RES, V8, DOI 10.1186/s13048-015-0131-9
   Várbíró S, 2022, NUTRIENTS, V14, DOI 10.3390/nu14081649
   Wang L, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00171
   Wang Q, 2022, NUTR RES, V100, P1, DOI 10.1016/j.nutres.2021.12.006
   Wei ZL., 2018, Cell, DOI [10.1016/j.cell.201, DOI 10.1016/J.CELL.201]
   Wimalawansa SJ, 2019, BIOLOGY-BASEL, V8, DOI 10.3390/biology8020030
   womenshealth, Polycystic Ovary Syndrome
   Xavier LB, 2019, GYNECOL ENDOCRINOL, V35, P146, DOI 10.1080/09513590.2018.1512966
NR 66
TC 1
Z9 1
U1 1
U2 6
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0932-0067
EI 1432-0711
J9 ARCH GYNECOL OBSTET
JI Arch. Gynecol. Obstet.
PD MAR
PY 2024
VL 309
IS 3
BP 907
EP 915
DI 10.1007/s00404-023-07227-x
EA SEP 2023
PG 9
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA HT9M2
UT WOS:001071601400001
PM 37747553
DA 2025-06-11
ER

PT J
AU Ojeda, ML
   Carreras, O
   del Valle, PM
   Murillo, ML
   Nogales, F
AF Luisa Ojeda, M.
   Carreras, Olimpia
   Munoz del Valle, Paulina
   Luisa Murillo, M.
   Nogales, Fatima
TI Fructose exposure during gestation and lactation altered hepatic
   selenoprotein expression, oxidative balance and metabolic profile in
   female rat pups
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Metabolic syndrome; Selenoprotein; Early nutrition; High fructose diet
ID GLUTATHIONE PEROXIDASES; INSULIN-RESISTANCE; ADULT MALE; SELENIUM;
   PREGNANCY; STRESS; DAMAGE; LIVER; GENE; HEPATOCYTES
AB Fructose-rich diets, an experimental model of induced metabolic syndrome (MS), affects pregnant and lactating rat dams, and moreover, it leads to an imbalance in their offspring's metabolic profile. Selenium (Se) homeostasis and body distribution is also altered. Selenoproteins: Glutathione peroxidase (GPx) and selenoprotein P (SelP) appear to play a role in MS. To evaluate selenoproteins' implication in the transmission of this pathology to the progeny, hepatic Se deposits, GPx activity, biomolecular oxidation and selenoproteins and AMPK expression were measured in the offspring of dams exposed to a fructose-rich diet (65%). Se intake and liver selenoproteins are affected by fructose exposition during early nutrition. Female fructose pups show a repletion of Se and oxidation in liver, higher GPx activity and expression of hepatic GPx1 and Se1P, related to a lower activation of AMPK and serum insulin levels. Fructose exposure during early nutrition negatively alters selenoproteins, oxidation and metabolism in female pups.
C1 [Luisa Ojeda, M.; Carreras, Olimpia; Munoz del Valle, Paulina; Luisa Murillo, M.; Nogales, Fatima] Univ Seville, Fac Pharm, Dept Physiol, C Prof Garcia Gonzalez 2, E-41012 Seville, Spain.
C3 University of Sevilla
RP Nogales, F (corresponding author), Univ Seville, Fac Pharm, Dept Physiol, C Prof Garcia Gonzalez 2, E-41012 Seville, Spain.
EM fnogales@us.es
RI Ojeda, Luisa/B-8571-2019; Carreras, olimpia/P-9078-2019; Nogales,
   F/B-8562-2019
OI Maria Luisa, Ojeda Murillo/0000-0002-9160-2749; Nogales,
   Fatima/0000-0003-4844-2740; Carreras, Olimpia/0000-0002-3858-0165
FU Andalusian Regional Government [CTS-193]
FX This work was supported by the Andalusian Regional Government (Support
   to CTS-193 research group).
CR Bonomini F, 2015, AGING DIS, V6, P109, DOI 10.14336/AD.2014.0305
   Brigelius-Flohé R, 1999, FREE RADICAL BIO MED, V27, P951, DOI 10.1016/S0891-5849(99)00173-2
   Brigelius-Flohé R, 2013, BBA-GEN SUBJECTS, V1830, P3289, DOI 10.1016/j.bbagen.2012.11.020
   Camargo A, 2014, FOOD CHEM TOXICOL, V72, P178, DOI 10.1016/j.fct.2014.07.024
   Carreras O., 2015, MOL ASPECTS ALCOHOL, P133
   Combs GF, 2015, NUTRIENTS, V7, P2209, DOI 10.3390/nu7042209
   Crosley LK, 2013, MOL NUTR FOOD RES, V57, P2185, DOI 10.1002/mnfr.201300216
   Day Caroline, 2007, Diab Vasc Dis Res, V4, P32, DOI 10.3132/dvdr.2007.003
   DRAPER HH, 1990, METHOD ENZYMOL, V186, P421
   Harreiter J, 2014, WOMENS HEALTH, V10, P91, DOI [10.2217/whe.13.69, 10.2217/WHE.13.69]
   Hill KE, 2003, J BIOL CHEM, V278, P13640, DOI 10.1074/jbc.M300755200
   Imai H, 2003, BIOCHEM BIOPH RES CO, V305, P278, DOI 10.1016/S0006-291X(03)00734-4
   Jung TW, 2014, MOL CELL ENDOCRINOL, V382, P66, DOI 10.1016/j.mce.2013.09.013
   Jung TW, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0066529
   Katunga LA, 2015, MOL METAB, V4, P493, DOI 10.1016/j.molmet.2015.04.001
   LAWRENCE RA, 1976, BIOCHEM BIOPH RES CO, V71, P952, DOI 10.1016/0006-291X(76)90747-6
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   Ojeda ML, 2016, FOOD FUNCT, V7, P3031, DOI [10.1039/c6fo00595k, 10.1039/C6FO00595K]
   Ojeda ML, 2009, ALCOHOL ALCOHOLISM, V44, P272, DOI 10.1093/alcalc/agp004
   Yubero-Serrano EM, 2013, EXP MOL MED, V45, DOI 10.1038/emm.2013.53
   Misu H, 2010, CELL METAB, V12, P483, DOI 10.1016/j.cmet.2010.09.015
   Mukai Y, 2014, CLIN EXP PHARMACOL P, V41, P331, DOI 10.1111/1440-1681.12225
   Nogales F, 2017, EUR J NUTR, V56, P819, DOI 10.1007/s00394-015-1129-1
   REZNICK AZ, 1994, METHOD ENZYMOL, V233, P357
   Rodríguez L, 2016, EUR J NUTR, V55, P665, DOI 10.1007/s00394-015-0886-1
   Rupérez AI, 2014, J NUTRIGENET NUTRIGE, V7, P130, DOI 10.1159/000368833
   Seale LA, 2012, MOL CELL BIOL, V32, P4141, DOI 10.1128/MCB.00293-12
   Serrano A, 2016, MOL NUTR FOOD RES, V60, P2633, DOI 10.1002/mnfr.201600511
   Sies H., 2007, ENCY STRESS, P45
   Sloboda DM, 2014, J OBES, V2014, DOI 10.1155/2014/203474
   Sonntag AG, 2012, FEBS J, V279, P3314, DOI 10.1111/j.1742-4658.2012.08582.x
   Steinbrenner H, 2006, FREE RADICAL RES, V40, P936, DOI 10.1080/10715760600806248
   Steinbrenner H, 2013, FREE RADICAL BIO MED, V65, P1538, DOI 10.1016/j.freeradbiomed.2013.07.016
   Tain YL, 2015, J NUTR BIOCHEM, V26, P642, DOI 10.1016/j.jnutbio.2014.12.017
   Tain YL, 2014, INT J MOL SCI, V15, P18484, DOI 10.3390/ijms151018484
   Takayama H, 2014, J BIOL CHEM, V289, P335, DOI 10.1074/jbc.M113.479386
   Takebe G, 2002, J BIOL CHEM, V277, P41254, DOI 10.1074/jbc.M202773200
   Tanti JF, 2009, CURR OPIN PHARMACOL, V9, P753, DOI 10.1016/j.coph.2009.07.004
   Vickers MH, 2011, ENDOCRINOLOGY, V152, P1378, DOI 10.1210/en.2010-1093
   Wang X, 2014, TOXICOL LETT, V224, P16, DOI 10.1016/j.toxlet.2013.10.005
   WORTHINGTON DJ, 1976, EUR J BIOCHEM, V67, P231, DOI 10.1111/j.1432-1033.1976.tb10654.x
   Zhou J, 2013, FREE RADICAL BIO MED, V65, P1548, DOI 10.1016/j.freeradbiomed.2013.07.012
   Zou M, 2012, NUTR RES, V32, P588, DOI 10.1016/j.nutres.2012.06.012
NR 43
TC 5
Z9 5
U1 0
U2 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD APR
PY 2018
VL 43
BP 77
EP 83
DI 10.1016/j.jff.2018.01.026
PG 7
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA GC4MG
UT WOS:000429758000010
DA 2025-06-11
ER

PT J
AU Cignarelli, M
   Lamacchia, O
AF Cignarelli, Mauro
   Lamacchia, Olga
TI Obesity and kidney disease
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Review
DE obesity; kidney; metabolic syndrome; remodeling; oxidative stress
ID BODY-MASS INDEX; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; MEDIATED GLOMERULAR
   INJURY; INDEPENDENT RISK-FACTOR; WEIGHT-LOSS; METABOLIC SYNDROME;
   OVERWEIGHT PATIENTS; PROGRESSIVE NATURE; DIABETES-MELLITUS;
   BLOOD-PRESSURE
AB The prevalence of obesity worldwide has increased dramatically. Besides, an approximately two-fold higher rate of increase in mean BMI among the incident ESRD has been reported in the US population from 1995-2002. Chronic kidney disease (CKD) prevalence increases from 2.9% among adults with an ideal BMI to 4.5% among obese adults. The development of CKD is usually the culminating result of the interaction of multiple risk factors. Obesity represents one example of a multitoxicity state and given the background of genetic susceptibility and/or reduced nephron number, overweight may initiate renal remodeling and/or accelerate kidney failure. Obesity may be the number one preventable risk factor for CKD. Weight toss has indeed been shown to improve glomerular hemodynamics and reduce urine albumin excretion. Thus, obese patients with CKD should be counseled on the benefits of weight toss. (c) 2007 Elsevier B.V. All rights reserved.
C1 [Cignarelli, Mauro; Lamacchia, Olga] Univ Foggia, Dept Med Sci, Unit Endocrinol & Metab Dis, I-71100 Foggia, Italy.
C3 University of Foggia
RP Cignarelli, M (corresponding author), Univ Foggia, Dept Med Sci, Unit Endocrinol & Metab Dis, Via Luigi Pinto 1, I-71100 Foggia, Italy.
EM m.cignarelli@unifg.it
RI Lamacchia, Olga/AEY-9588-2022
OI Lamacchia, Olga/0000-0002-9175-489X
CR Adelman RD, 2001, J PEDIATR-US, V138, P481, DOI 10.1067/mpd.2001.113006
   Anderson CAM, 2006, ADV CHRONIC KIDNEY D, V13, P394, DOI 10.1053/j.ackd.2006.07.001
   Bagby SP, 2004, J AM SOC NEPHROL, V15, P2775, DOI 10.1097/01.ASN.0000141965.28037.EE
   Bonnet F, 2001, AM J KIDNEY DIS, V37, P720, DOI 10.1016/S0272-6386(01)80120-7
   BRENNER BM, 1983, KIDNEY INT, V23, P647, DOI 10.1038/ki.1983.72
   BRENNER BM, 1982, NEW ENGL J MED, V307, P652, DOI 10.1056/NEJM198209093071104
   Camp TM, 2003, DIABETOLOGIA, V46, P1438, DOI 10.1007/s00125-003-1200-y
   Chagnac A, 2000, AM J PHYSIOL-RENAL, V278, pF817, DOI 10.1152/ajprenal.2000.278.5.F817
   Chagnac A, 2003, J AM SOC NEPHROL, V14, P1480, DOI 10.1097/01.ASN.0000068462.38661.89
   Chander PN, 2004, J AM SOC NEPHROL, V15, P2391, DOI 10.1097/01.ASN.0000135971.88164.2C
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Cirillo M, 1998, ARCH INTERN MED, V158, P1933, DOI 10.1001/archinte.158.17.1933
   Coresh J, 2005, J AM SOC NEPHROL, V16, P180, DOI 10.1681/ASN.2004070539
   Correia MLD, 2004, CURR OPIN NEPHROL HY, V13, P215, DOI 10.1097/01.mnh.0000119533.79618.b3
   Cortes P, 1996, AM J PHYSIOL-RENAL, V270, pF356, DOI 10.1152/ajprenal.1996.270.2.F356
   Cortes P, 1996, CONTRIB NEPHROL, V118, P229
   De Cosmo S, 2006, DIABETES CARE, V29, P2467, DOI 10.2337/dc06-0940
   Despres JP, 2005, NEW ENGL J MED, V353, P2121, DOI 10.1056/NEJMoa044537
   Drafts HH, 1997, CLIN TRANSPLANT, V11, P493
   Du XL, 2006, J CLIN INVEST, V116, P1071, DOI 10.1172/JCI23354
   Ducloux D, 2005, AM J TRANSPLANT, V5, P2922, DOI 10.1111/j.1600-6143.2005.01104.x
   El-Atat FA, 2004, J AM SOC NEPHROL, V15, P2816, DOI 10.1097/01.ASN.0000133698.80390.37
   Engeli S, 2005, HYPERTENSION, V45, P356, DOI 10.1161/01.HYP.0000154361.47683.d3
   Fernandez-Twinn DS, 2006, PHYSIOL BEHAV, V88, P234, DOI 10.1016/j.physbeh.2006.05.039
   Fredrickson SK, 2004, DIABETES CARE, V27, P1754, DOI 10.2337/diacare.27.7.1754
   González E, 2005, KIDNEY INT, V68, P263, DOI 10.1111/j.1523-1755.2005.00401.x
   Guilbert J J, 2003, Educ Health (Abingdon), V16, P230
   Hall JE, 2003, HYPERTENSION, V41, P625, DOI 10.1161/01.HYP.0000052314.95497.78
   Hayden MR, 2005, AM J NEPHROL, V25, P553, DOI 10.1159/000088810
   Henegar JR, 2001, J AM SOC NEPHROL, V12, P1211, DOI 10.1681/ASN.V1261211
   HOSTETTER TH, 1981, AM J PHYSIOL, V241, pF85, DOI 10.1681/ASN.V1261315
   HOSTETTER TH, 1982, AM J KIDNEY DIS, V1, P310, DOI 10.1016/S0272-6386(82)80032-2
   Howard RJ, 2002, TRANSPLANTATION, V73, P53, DOI 10.1097/00007890-200201150-00009
   Hsu CY, 2006, ANN INTERN MED, V144, P21, DOI 10.7326/0003-4819-144-1-200601030-00006
   Hunt MJ, 2002, AM J PHYSIOL-LUNG C, V283, pL239, DOI 10.1152/ajplung.00001.2002
   Kambham N, 2001, KIDNEY INT, V59, P1498, DOI 10.1046/j.1523-1755.2001.0590041498.x
   KASISKE BL, 1985, AM J NEPHROL, V5, P45, DOI 10.1159/000166902
   Kim YI, 2001, DIABETES RES CLIN PR, V52, P145, DOI 10.1016/S0168-8227(01)00228-5
   Kramer HJ, 2006, J AM SOC NEPHROL, V17, P1453, DOI 10.1681/ASN.2005111241
   Liese AD, 2001, J HUM HYPERTENS, V15, P799, DOI 10.1038/sj.jhh.1001266
   Meier-Kriesche HU, 2002, TRANSPLANTATION, V73, P70, DOI 10.1097/00007890-200201150-00013
   METCALF P, 1992, CLIN CHEM, V38, P1802
   Morales E, 2003, AM J KIDNEY DIS, V41, P319, DOI 10.1053/ajkd.2003.50039
   *NAT KIDN FDN, 2002, AM J KIDNEY DIS S, V39, pS72
   Ogden CL, 2002, JAMA-J AM MED ASSOC, V288, P1728, DOI 10.1001/jama.288.14.1728
   Palomar R, 2005, OBES SURG, V15, P794, DOI 10.1381/0960892054222687
   Pausova Z, 2006, CURR OPIN NEPHROL HY, V15, P173, DOI 10.1097/01.mnh.0000214775.42103.a5
   Porter LE, 1998, HYPERTENSION, V32, P144, DOI 10.1161/01.HYP.32.1.144
   Praga M, 2005, NEPHROL DIAL TRANSPL, V20, P2594, DOI 10.1093/ndt/gfi201
   Praga M, 2001, NEPHROL DIAL TRANSPL, V16, P1790, DOI 10.1093/ndt/16.9.1790
   Praga M, 1999, AM J KIDNEY DIS, V33, P52, DOI 10.1016/S0272-6386(99)70257-X
   PRAGA M, 1995, NEPHRON, V70, P35, DOI 10.1159/000188541
   Praga M, 2002, NEPHROL DIAL TRANSPL, V17, P1157, DOI 10.1093/ndt/17.7.1157
   PURKERSON ML, 1976, KIDNEY INT, V9, P407, DOI 10.1038/ki.1976.50
   REISIN E, 1987, J HYPERTENS, V5, P397
   RENNKE HG, 1989, AM J KIDNEY DIS, V13, P443, DOI 10.1016/S0272-6386(89)80001-0
   RIBSTEIN J, 1995, HYPERTENSION, V26, P610, DOI 10.1161/01.HYP.26.4.610
   Sagrinati C, 2006, J AM SOC NEPHROL, V17, P2443, DOI 10.1681/ASN.2006010089
   Shastry Suresh, 2003, Curr Cardiol Rep, V5, P200, DOI 10.1007/s11886-003-0049-5
   Tyagi SC, 2003, HEART FAIL REV, V8, P23, DOI 10.1023/A:1022138803293
   Uemura S, 2001, CIRC RES, V88, P1291, DOI 10.1161/hh1201.092042
   *US REN DAT SYST, 2005, 2005 USRDS
   Wadden TA, 2005, NEW ENGL J MED, V353, P2111, DOI 10.1056/NEJMoa050156
   Wolf G, 1999, KIDNEY INT, V56, P860, DOI 10.1046/j.1523-1755.1999.00626.x
   Wu YC, 2006, ENDOCRINOLOGY, V147, P44, DOI 10.1210/en.2005-0641
   Yamamoto S, 2002, CLIN TRANSPLANT, V16, P252, DOI 10.1034/j.1399-0012.2002.01080.x
NR 66
TC 53
Z9 60
U1 0
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD DEC
PY 2007
VL 17
IS 10
BP 757
EP 762
DI 10.1016/j.numecd.2007.03.003
PG 6
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 252QI
UT WOS:000252460900009
PM 17606365
DA 2025-06-11
ER

PT J
AU Lang, F
   Gawaz, M
   Borst, O
AF Lang, F.
   Gawaz, M.
   Borst, O.
TI The serum- & glucocorticoid-inducible kinase in the regulation of
   platelet function
SO ACTA PHYSIOLOGICA
LA English
DT Review
DE Ca2+; metabolic syndrome; Orai1; platelets; SGK1; thrombus formation
ID CA2+ CHANNEL ORAI1; PATHOGENIC T(H)17 CELLS; THROMBUS FORMATION;
   KAPPA-B; PROCOAGULANT RESPONSE; CALCIUM-CONCENTRATION; ARTERIAL
   THROMBOSIS; DIABETES-MELLITUS; TISSUE FACTOR; UP-REGULATION
AB The serum- and glucocorticoid-inducible kinase 1 (SGK1) is expressed in megakaryocytes and circulating platelets. In megakaryocytes, SGK1 activates transcription factor nuclear factor kappa-B (NF-B), which in turn stimulates expression of Orai1, a Ca2+ channel protein accomplishing store-operated Ca2+ enrty (SOCE). SGK1 enhances SOCE and several Ca2+-sensitive platelet functions, including degranulation, integrin (IIb3) activation, phosphatidylserine exposure, aggregation and thrombus formation. As shown in other cell types, stimulators of SGK1 expression include ischaemia, oxidative stress, hyperglycaemia, advanced glycation end products (AGEs) and a variety of hormones such as glucocorticoids, mineralocorticoids, transforming growth factor beta (TGF), interleukin 6 (IL-6), platelet-derived growth factor (PDGF), thrombin and endothelin. Thus, SGK1-sensitive Ca2+ signalling may contribute to altered platelet function in several clinical conditions including inflammation, metabolic syndrome, diabetes mellitus and chronic renal failure. Nevertheless, further studies are needed defining the contribution of altered SGK1 expression and activity to physiology and pathophysiology of platelets.
C1 [Lang, F.; Borst, O.] Univ Tubingen, Dept Physiol, Gmelinstr 5, D-72076 Tubingen, Germany.
   [Gawaz, M.; Borst, O.] Univ Tubingen, Dept Cardiol & Cardiovasc Med, D-72076 Tubingen, Germany.
C3 Eberhard Karls University of Tubingen; Eberhard Karls University of
   Tubingen
RP Lang, F (corresponding author), Univ Tubingen, Dept Physiol, Gmelinstr 5, D-72076 Tubingen, Germany.
EM florian.lang@uni-tuebingen.de
OI Borst, Oliver/0000-0003-4002-4085
CR Alexandru N, 2007, PLATELETS, V18, P473, DOI 10.1080/09537100701507619
   [Anonymous], 2013, COCHRANE DB SYST REV
   Authi K. S., 2007, V179, P425
   Authi KS, 2009, BLOOD, V113, P1872, DOI 10.1182/blood-2008-11-185959
   Baker RG, 2011, CELL METAB, V13, P11, DOI 10.1016/j.cmet.2010.12.008
   Beaulieu LM, 2011, BLOOD, V117, P5963, DOI 10.1182/blood-2010-09-304949
   BelAiba RS, 2006, CIRC RES, V98, P828, DOI 10.1161/01.RES.0000210539.54861.27
   Bergmeier W, 2009, J THROMB HAEMOST, V7, P187, DOI 10.1111/j.1538-7836.2009.03379.x
   Berna-Erro A, 2012, BBA-MOL CELL RES, V1823, P1242, DOI 10.1016/j.bbamcr.2012.05.023
   Borst O, 2014, FASEB J, V28, P2108, DOI 10.1096/fj.13-239277
   Borst O, 2013, CELL PHYSIOL BIOCHEM, V31, P914, DOI 10.1159/000350110
   Borst O, 2012, CIRC RES, V111, P1297, DOI 10.1161/CIRCRESAHA.112.276444
   Borst O, 2012, BLOOD, V119, P251, DOI 10.1182/blood-2011-06-359976
   Braun A, 2009, BLOOD, V113, P2056, DOI 10.1182/blood-2008-07-171611
   Briet M, 2013, J VASC RES, V50, P89, DOI 10.1159/000345243
   Chatterjee M, 2013, J THROMB HAEMOST, V11, P1954, DOI 10.1111/jth.12404
   Chen JH, 2004, BLOOD, V104, P1703, DOI 10.1182/blood-2003-10-3428
   Chen X, 2013, BLOOD, V121, P3718, DOI 10.1182/blood-2012-10-461897
   Dahlberg J, 2011, J HYPERTENS, V29, P884, DOI 10.1097/HJH.0b013e3283455117
   Davenport R, 2013, TRANSFUSION, V53, p23S, DOI 10.1111/trf.12032
   Denis MM, 2005, CELL, V122, P379, DOI 10.1016/j.cell.2005.06.015
   Dionisio N, 2012, CURR MOL MED, V12, P1319, DOI 10.2174/156652412803833616
   El Haouari M, 2008, BLOOD CELL MOL DIS, V41, P119, DOI 10.1016/j.bcmd.2008.02.010
   Eylenstein A, 2011, FASEB J, V25, P2012, DOI 10.1096/fj.10-178210
   Fahim MA, 2001, ANAT REC, V263, P85, DOI 10.1002/ar.1080
   Fateh-Moghadam S, 2005, ARTERIOSCL THROM VAS, V25, P1299, DOI 10.1161/01.ATV.0000165699.41301.c5
   Ferreira IA, 2006, ARTERIOSCL THROM VAS, V26, P417, DOI 10.1161/01.ATV.0000199519.37089.a0
   Ferroni P, 2012, ANTIOXID REDOX SIGN, V17, P1447, DOI 10.1089/ars.2011.4324
   Feske S, 2010, PFLUG ARCH EUR J PHY, V460, P417, DOI 10.1007/s00424-009-0777-5
   Galan C, 2009, ARCH BIOCHEM BIOPHYS, V490, P137, DOI 10.1016/j.abb.2009.08.007
   Gawaz M, 2005, J CLIN INVEST, V115, P3378, DOI 10.1172/JCI27196
   Gawaz M, 2004, CARDIOVASC RES, V61, P498, DOI 10.1016/j.cardiores.2003.11.036
   Gawaz M, 2013, BLOOD, V122, P2550, DOI 10.1182/blood-2013-05-468694
   Gawaz M, 2011, ARTERIOSCL THROM VAS, V31, P1949, DOI 10.1161/ATVBAHA.111.232173
   Gilio K, 2010, J BIOL CHEM, V285, P23629, DOI 10.1074/jbc.M110.108696
   Grosse J, 2007, J CLIN INVEST, V117, P3540, DOI 10.1172/JCI32312
   Hunter RW, 2009, J THROMB HAEMOST, V7, P2123, DOI 10.1111/j.1538-7836.2009.03637.x
   Jardín I, 2011, BLOOD CELL MOL DIS, V46, P252, DOI 10.1016/j.bcmd.2010.12.008
   Jardín I, 2009, BBA-MOL CELL RES, V1793, P1614, DOI 10.1016/j.bbamcr.2009.07.003
   Jardin I, 2009, BIOCHEM J, V420, P267, DOI 10.1042/BJ20082179
   Karin M, 2004, NAT REV DRUG DISCOV, V3, P17, DOI 10.1038/nrd1279
   Kleinewietfeld M, 2013, NATURE, V496, P518, DOI 10.1038/nature11868
   Kusch A, 2013, ACTA PHYSIOL, V208, P25, DOI 10.1111/apha.12089
   Lang F, 2006, PHYSIOL REV, V86, P1151, DOI 10.1152/physrev.00050.2005
   Lang F, 2013, THROMB HAEMOSTASIS, V110, P925, DOI 10.1160/TH13-02-0176
   Lang F, 2013, HORM-INT J ENDOCRINO, V12, P160, DOI 10.14310/horm.2002.1401
   Lang F, 2009, EXPERT OPIN THER TAR, V13, P1303, DOI 10.1517/14728220903260807
   Li DJ, 2008, BLOOD, V111, P3522, DOI 10.1182/blood-2007-09-111518
   Lindemann S, 2001, J BIOL CHEM, V276, P33947, DOI 10.1074/jbc.M104281200
   Liu GX, 2013, KIDNEY BLOOD PRESS R, V38, P21, DOI 10.1159/000355750
   LU KC, 1994, Q J MED, V87, P359
   Mattoscio D, 2010, FASEB J, V24, P3970, DOI 10.1096/fj.10-159921
   May AE, 2008, ARTERIOSCL THROM VAS, V28, pS5, DOI 10.1161/ATVBAHA.107.158915
   McCloskey C, 2010, J PHYSIOL-LONDON, V588, P1399, DOI 10.1113/jphysiol.2010.188136
   Moody WE, 2013, HEART, V99, P365, DOI 10.1136/heartjnl-2012-302818
   Moore SF, 2013, J BIOL CHEM, V288, P3918, DOI 10.1074/jbc.M112.429936
   Münzer P, 2014, ARTERIOSCL THROM VAS, V34, P61, DOI 10.1161/ATVBAHA.112.300210
   Münzer P, 2013, BIOCHEM BIOPH RES CO, V436, P25, DOI 10.1016/j.bbrc.2013.05.031
   Mutoh A, 2008, HYPERTENS RES, V31, P1811, DOI 10.1291/hypres.31.1811
   Nemmar A, 2013, CELL PHYSIOL BIOCHEM, V31, P15, DOI 10.1159/000343345
   O'Brien KA, 2011, BLOOD, V118, P4215, DOI 10.1182/blood-2010-12-323204
   Ogawa A, 2012, AM J PHYSIOL-CELL PH, V302, pC405, DOI 10.1152/ajpcell.00337.2011
   OHHASHI S, 1992, J HUM HYPERTENS, V6, P71
   Pabla R, 1999, J CELL BIOL, V144, P175, DOI 10.1083/jcb.144.1.175
   Pasham V, 2013, KIDNEY BLOOD PRESS R, V37, P48, DOI 10.1159/000343401
   Pelzl L, 2013, CELL PHYSIOL BIOCHEM, V32, P210, DOI 10.1159/000356640
   Pelzl L, 2012, BIOCHEM BIOPH RES CO, V425, P1, DOI 10.1016/j.bbrc.2012.07.026
   Ramanathan G, 2012, J THROMB HAEMOST, V10, P419, DOI 10.1111/j.1538-7836.2011.04596.x
   Rosskopf D, 1999, J THROMB THROMBOLYS, V8, P15, DOI 10.1023/A:1008986329267
   Ruggeri ZM, 2002, NAT MED, V8, P1227, DOI 10.1038/nm1102-1227
   Schmid E, 2012, CELL PHYSIOL BIOCHEM, V30, P1423, DOI 10.1159/000343330
   Schmidt EM, 2012, CELL PHYSIOL BIOCHEM, V30, P259, DOI 10.1159/000339062
   Schmidt EM, 2011, BIOCHEM BIOPH RES CO, V415, P54, DOI 10.1016/j.bbrc.2011.10.009
   Schoenwaelder SM, 2009, BLOOD, V114, P663, DOI 10.1182/blood-2009-01-200345
   Schwertz H, 2006, J EXP MED, V203, P2433, DOI 10.1084/jem.20061302
   Seizer P, 2008, CURR MED CHEM, V15, P1976, DOI 10.2174/092986708785132852
   Sekizawa N, 2011, MOL CELL ENDOCRINOL, V341, P78, DOI 10.1016/j.mce.2011.05.029
   Smith KA, 2012, CIRC RES, V111, P9, DOI 10.1161/CIRCRESAHA.112.271791
   Spinelli SL, 2010, SCI SIGNAL, V3, DOI 10.1126/scisignal.3144pe37
   Spinelli SL, 2010, ARTERIOSCL THROM VAS, V30, P591, DOI 10.1161/ATVBAHA.109.197343
   Tolios A, 2013, THROMB HAEMOSTASIS, V110, P386, DOI 10.1160/TH12-09-0701
   Tomasiak M, 2007, ACTA BIOCHIM POL, V54, P625, DOI 10.18388/abp.2007_3236
   Towhid ST, 2013, CELL PHYSIOL BIOCHEM, V31, P102, DOI 10.1159/000343353
   van Kruchten R, 2012, ARTERIOSCL THROM VAS, V32, P1717, DOI 10.1161/ATVBAHA.111.243907
   Varga-Szabo D, 2009, J THROMB HAEMOST, V7, P1057, DOI 10.1111/j.1538-7836.2009.03455.x
   Varga-Szabo D, 2008, J EXP MED, V205, P1583, DOI 10.1084/jem.20080302
   Voelkl J, 2013, CELL PHYSIOL BIOCHEM, V32, P25, DOI 10.1159/000350120
   Wang BY, 2013, CELL PHYSIOL BIOCHEM, V32, P1741, DOI 10.1159/000356608
   WARE JA, 1989, BLOOD, V73, P172
   Weng Z, 2010, BLOOD, V116, P2579, DOI 10.1182/blood-2010-03-277236
   Weyrich AS, 2009, J THROMB HAEMOST, V7, P241, DOI 10.1111/j.1538-7836.2008.03211.x
   Wolfs JL, 2006, BLOOD, V108, P2223, DOI 10.1182/blood-2006-01-009613
   Woulfe D, 2004, J CLIN INVEST, V113, P441, DOI 10.1172/JCI200420267
   Wu C, 2013, NATURE, V496, P513, DOI 10.1038/nature11984
   Yin H, 2008, BLOOD, V111, P658, DOI 10.1182/blood-2007-04-085514
   Zbidi H, 2009, BLOOD CELL MOL DIS, V43, P211, DOI 10.1016/j.bcmd.2009.04.005
NR 96
TC 19
Z9 21
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1748-1708
EI 1748-1716
J9 ACTA PHYSIOL
JI Acta Physiol.
PD JAN
PY 2015
VL 213
IS 1
BP 181
EP 190
DI 10.1111/apha.12334
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA AW7XN
UT WOS:000346475000013
PM 24947805
DA 2025-06-11
ER

PT J
AU Norberto, S
   Silva, S
   Meireles, M
   Faria, A
   Pintado, M
   Calhau, C
AF Norberto, Sonia
   Silva, Sara
   Meireles, Manuela
   Faria, Ana
   Pintado, Manuela
   Calhau, Conceicao
TI Blueberry anthocyanins in health promotion: A metabolic overview
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Review
DE Anthocyanin; Bioavailability; Blueberry; Metabolic syndrome; Obesity
ID BILBERRY VACCINIUM-MYRTILLUS; ANTIOXIDANT ACTIVITY; PHENOLIC-COMPOUNDS;
   CYANIDIN 3-O-BETA-D-GLUCOSIDE; BERRY ANTHOCYANINS; INTESTINAL UPTAKE;
   OXIDATIVE STRESS; GENE-EXPRESSION; WHOLE BERRIES; ELDERLY WOMEN
AB Diet has gained scientific community attention due to the crucial role in health maintenance, but also in disease treatment, and essential in disease prevention. Several food and food components, particularly phenolic rich foods, have been investigated as they present themselves as putative functional foods. In the past decades, obesity has reached epidemic proportions and consequently, metabolic syndrome (a set of disorders as impaired glucose tolerance, insulin resistance, abdominal obesity, dyslipidemia and high blood pressure, which increase the risk of cardiovascular disease and diabetes) incidence is increasing worldwide at an alarming rate and this phenolic rich foods, specially berries have been investigated to their potential beneficial effect in this disorders.
   In the present work the chemistry of blueberries (BB) (fruits of some Vaccinium species) was summarised as well as the knowledge about bioavailability and biokinetic of anthocyanins from blueberries with particular emphasis on its implications in metabolic disorders. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Norberto, Sonia; Meireles, Manuela; Faria, Ana; Calhau, Conceicao] Univ Porto, Fac Med, Dept Biochem, P-4200319 Porto, Portugal.
   [Silva, Sara; Pintado, Manuela] Univ Catolica Portuguesa, CBQF Escola Super Biotecnol, Porto, Portugal.
   [Faria, Ana] Univ Porto, Fac Sci, Chem Invest Ctr CIQ, P-4200319 Porto, Portugal.
   [Faria, Ana] Univ Porto, Fac Nutr & Food Sci, P-4200319 Porto, Portugal.
   [Calhau, Conceicao] CINTESIS Ctr Invest Tecnol & Sistemas Informacao, Porto, Portugal.
C3 Universidade do Porto; Universidade Catolica Portuguesa; Universidade do
   Porto; Universidade do Porto
RP Calhau, C (corresponding author), Univ Porto, Fac Med, Dept Biochem, P-4200319 Porto, Portugal.
EM ccalhau@med.up.pt
RI Silva, Sara/GXM-8709-2022; Faria, Ana/A-5176-2013; Meireles,
   Manuela/L-2472-2018; Pintado, Maria Manuela/AAW-6709-2021; Calhau,
   Conceição/L-8041-2013; Pintado, Maria Manuela/F-5696-2013
OI Silva, Sara/0000-0001-8268-2137; Silva, Sara/0000-0002-0896-9946;
   Pintado, Maria Manuela/0000-0002-0760-3184; Norberto,
   Sonia/0000-0002-5388-3682; Meireles, Manuela/0000-0003-3703-0011; Faria,
   Ana/0000-0002-5165-9513; Calhau, Conceicao/0000-0001-9567-3379
FU Fundacao para a Ciencia e Tecnologia (FCT) - Fundo Social Europeu,
   Programa Operacional Potencial Humano da EU (POPH) [SFRH/BPD/75294/2010,
   SFRH/BD/78367/2011, SFRH/BD/90867/2012]; QREN - SI I&DT: MYRTILLUS -
   Mirtilos corn inovacao [13736]; Fundação para a Ciência e a Tecnologia
   [SFRH/BD/78367/2011, SFRH/BD/90867/2012] Funding Source: FCT
FX Financial support from Fundacao para a Ciencia e Tecnologia (FCT) -
   Fundo Social Europeu, Programa Operacional Potencial Humano da EU
   (POPH), SFRH/BPD/75294/2010, SFRH/BD/78367/2011 and SFRH/BD/90867/2012
   is gratefully acknowledged. Supported by 13736 QREN - SI I&DT: MYRTILLUS
   - Mirtilos corn inovacao.
CR Al-Awwadi NA, 2005, J AGR FOOD CHEM, V53, P151, DOI 10.1021/jf048919f
   Andlauer W, 2003, EUR J NUTR, V42, P217, DOI 10.1007/s00394-003-0417-3
   Andres-Lacueva C, 2005, NUTR NEUROSCI, V8, P111, DOI 10.1080/10284150500078117
   Aura AM, 2005, EUR J NUTR, V44, P133, DOI 10.1007/s00394-004-0502-2
   Bakker J, 1997, J AGR FOOD CHEM, V45, P35, DOI 10.1021/jf960252c
   Barros D, 2006, PHARMACOL BIOCHEM BE, V84, P229, DOI 10.1016/j.pbb.2006.05.001
   Blakely S, 2003, J NUTR, V133, P2838, DOI 10.1093/jn/133.9.2838
   Borges G, 2010, J AGR FOOD CHEM, V58, P3901, DOI 10.1021/jf902263n
   Cao GH, 2001, AM J CLIN NUTR, V73, P920
   Chambers BK, 2003, DIABETES CARE, V26, P2695, DOI 10.2337/diacare.26.9.2695-a
   Connor AM, 2002, J AGR FOOD CHEM, V50, P893, DOI 10.1021/jf011212y
   DeFuria J, 2009, J NUTR, V139, P1510, DOI 10.3945/jn.109.105155
   Del Bò C, 2010, J AGR FOOD CHEM, V58, P2491, DOI 10.1021/jf903472x
   Demircan N, 2008, MED SCI MONITOR, V14, pCR97
   Faria A, 2006, FEBS LETT, V580, P155, DOI 10.1016/j.febslet.2005.11.068
   Faria A, 2005, J AGR FOOD CHEM, V53, P6896, DOI 10.1021/jf0511300
   Faria A, 2008, FOOD CHEM, V109, P587, DOI 10.1016/j.foodchem.2008.01.009
   Faria A, 2010, PHYTOTHER RES, V24, P1862, DOI 10.1002/ptr.3213
   Faria A, 2009, MOL NUTR FOOD RES, V53, P1430, DOI 10.1002/mnfr.200900007
   Felgines C, 2003, J NUTR, V133, P1296
   Fernandes I, 2012, FOOD FUNCT, V3, P508, DOI 10.1039/c2fo10295a
   Fossen T, 2003, PHYTOCHEMISTRY, V62, P1217, DOI 10.1016/S0031-9422(02)00746-X
   Fulcrand H, 1998, PHYTOCHEMISTRY, V47, P1401, DOI 10.1016/S0031-9422(97)00772-3
   Grace MH, 2009, PHYTOMEDICINE, V16, P406, DOI 10.1016/j.phymed.2009.02.018
   Hollman PCH, 1999, FOOD CHEM TOXICOL, V37, P937, DOI 10.1016/S0278-6915(99)00079-4
   Hopps E, 2010, NUTR METAB CARDIOVAS, V20, P72, DOI 10.1016/j.numecd.2009.06.002
   Hurrell RF, 1999, BRIT J NUTR, V81, P289, DOI 10.1017/S0007114599000537
   Ichiyanagi T, 2006, J AGR FOOD CHEM, V54, P6578, DOI 10.1021/jf0602370
   Jankowski A, 2000, Folia Med Cracov, V41, P5
   Jayaprakasam B, 2005, J AGR FOOD CHEM, V53, P28, DOI 10.1021/jf049018+
   Johansen JS, 2005, CARDIOVASC DIABETOL, V4, DOI 10.1186/1475-2840-4-5
   Joseph JA, 2003, NUTR NEUROSCI, V6, P153, DOI 10.1080/1028415031000111282
   Jovanovic L, 1999, ANN CLIN LAB SCI, V29, P33
   Kader F, 1996, FOOD CHEM, V55, P35, DOI 10.1016/0308-8146(95)00068-2
   Kähkönen MP, 2003, J AGR FOOD CHEM, V51, P628, DOI 10.1021/jf025551i
   Kähkönen MP, 2001, J AGR FOOD CHEM, V49, P4076, DOI 10.1021/jf010152t
   Kalt W, 2001, J AGR FOOD CHEM, V49, P4761, DOI 10.1021/jf010653e
   Kalt W, 2008, J AGR FOOD CHEM, V56, P705, DOI 10.1021/jf071998l
   Karlsen A, 2010, EUR J NUTR, V49, P345, DOI 10.1007/s00394-010-0092-0
   Kay CD, 2004, BRIT J NUTR, V91, P933, DOI 10.1079/BJN20041126
   Kay CD, 2005, J NUTR, V135, P2582, DOI 10.1093/jn/135.11.2582
   Kong JM, 2003, PHYTOCHEMISTRY, V64, P923, DOI 10.1016/S0031-9422(03)00438-2
   Landrault N, 2003, J AGR FOOD CHEM, V51, P311, DOI 10.1021/jf020219s
   Li LY, 2009, J AGR FOOD CHEM, V57, P826, DOI 10.1021/jf803407q
   Liang Y., 2012, EUROPEAN J NUTR
   Lila M. A., 2011, J AGR FOOD CHEM
   Manach C, 2005, AM J CLIN NUTR, V81, p230S, DOI 10.1093/ajcn/81.1.230S
   Maritim AC, 2003, J BIOCHEM MOL TOXIC, V17, P24, DOI 10.1002/jbt.10058
   Martineau LC, 2006, PHYTOMEDICINE, V13, P612, DOI 10.1016/j.phymed.2006.08.005
   Mateus N, 2003, J AGR FOOD CHEM, V51, P1919, DOI 10.1021/jf020943a
   Mateus N, 2001, J AGR FOOD CHEM, V49, P4836, DOI 10.1021/jf001505b
   Matsumoto H, 2001, J AGR FOOD CHEM, V49, P1546, DOI 10.1021/jf001246q
   Mazza G, 2002, J AGR FOOD CHEM, V50, P7731, DOI 10.1021/jf020690l
   McGhie TK, 2007, MOL NUTR FOOD RES, V51, P702, DOI 10.1002/mnfr.200700092
   Meydani M, 2010, NUTRIENTS, V2, P737, DOI 10.3390/nu2070737
   Milbury PE, 2002, MECH AGEING DEV, V123, P997, DOI 10.1016/S0047-6374(01)00383-9
   Miyazawa T, 1999, J AGR FOOD CHEM, V47, P1083, DOI 10.1021/jf9809582
   Molan AL, 2009, INT J FOOD SCI NUTR, V60, P497, DOI 10.1080/09637480701781490
   Monteiro R, 2005, N-S ARCH PHARMACOL, V372, P147, DOI 10.1007/s00210-005-0012-7
   Monteiro R, 2005, LIFE SCI, V76, P2483, DOI 10.1016/j.lfs.2004.12.008
   Monteiro R, 2006, OBES SURG, V16, P804, DOI 10.1381/096089206777346600
   Mülleder U, 2002, J BIOCHEM BIOPH METH, V53, P61, DOI 10.1016/S0165-022X(02)00093-3
   Nielsen ILF, 2003, J AGR FOOD CHEM, V51, P2813, DOI 10.1021/jf025947u
   Pacheco-Palencia LA, 2010, FOOD CHEM, V119, P1071, DOI 10.1016/j.foodchem.2009.08.017
   Passamonti S, 2002, BIOCHEM BIOPH RES CO, V296, P631, DOI 10.1016/S0006-291X(02)00927-0
   Passamonti S, 2003, FEBS LETT, V544, P210, DOI 10.1016/S0014-5793(03)00504-0
   Perkins-Veazie P, 2008, POSTHARVEST BIOL TEC, V47, P280, DOI 10.1016/j.postharvbio.2007.08.002
   Prior RL, 2008, J AGR FOOD CHEM, V56, P647, DOI 10.1021/jf071993o
   Prior RL, 2006, FREE RADICAL RES, V40, P1014, DOI 10.1080/10715760600758522
   Prior RL, 2010, J AGR FOOD CHEM, V58, P3970, DOI 10.1021/jf902852d
   Prior RL, 2009, MOL NUTR FOOD RES, V53, P1406, DOI 10.1002/mnfr.200900026
   Riihinen K, 2008, FOOD CHEM, V110, P156, DOI 10.1016/j.foodchem.2008.01.057
   Riso P., 2012, EUROPEAN J NUTR
   Rodriguez-Mateos A., 2012, J AGR FOOD CHEM
   Ross SA, 2004, CHEM REV, V104, P1255, DOI 10.1021/cr0204653
   Sakakibara H, 2009, J AGR FOOD CHEM, V57, P7681, DOI 10.1021/jf901341b
   Santos-Buelga C, 2000, J SCI FOOD AGR, V80, P1094, DOI [10.1002/(SICI)1097-0010(20000515)80:7<1094::AID-JSFA569>3.0.CO;2-1, 10.1002/(SICI)1097-0010(20000515)80:7<1094::AID-JSFA569>3.3.CO;2-T]
   Scalbert A, 2002, BIOMED PHARMACOTHER, V56, P276, DOI 10.1016/S0753-3322(02)00205-6
   Schreckinger ME, 2010, J AGR FOOD CHEM, V58, P8966, DOI 10.1021/jf100975m
   Schuster DP, 2010, DIABETES METAB SYNDR, V3, P253, DOI 10.2147/DMSO.S7354
   Stull AJ, 2010, J NUTR, V140, P1764, DOI 10.3945/jn.110.125336
   Suda I, 2002, J AGR FOOD CHEM, V50, P1672, DOI 10.1021/jf011162x
   Suzuki R, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-14
   Talavéra S, 2005, J AGR FOOD CHEM, V53, P3902, DOI 10.1021/jf050145v
   Talavéra S, 2003, J NUTR, V133, P4178, DOI 10.1093/jn/133.12.4178
   Talavéra S, 2004, J NUTR, V134, P2275, DOI 10.1093/jn/134.9.2275
   TAMURA G, 1980, P NATL ACAD SCI-BIOL, V77, P4961, DOI 10.1073/pnas.77.8.4961
   Taruscio TG, 2004, J AGR FOOD CHEM, V52, P3169, DOI 10.1021/jf0307595
   Titta L, 2010, INT J OBESITY, V34, P578, DOI 10.1038/ijo.2009.266
   Tsuda T, 2003, J NUTR, V133, P2125, DOI 10.1093/jn/133.7.2125
   Tsuda T, 1999, ARCH BIOCHEM BIOPHYS, V368, P361, DOI 10.1006/abbi.1999.1311
   Tsuda T, 2005, BBA-MOL CELL BIOL L, V1733, P137, DOI 10.1016/j.bbalip.2004.12.014
   TSUDA T, 1994, J AGR FOOD CHEM, V42, P2407, DOI 10.1021/jf00047a009
   Tsuda T, 1996, LIPIDS, V31, P1259, DOI 10.1007/BF02587910
   Tsuda T, 2004, BIOCHEM BIOPH RES CO, V316, P149, DOI 10.1016/j.bbrc.2004.02.031
   Tsuda T, 2008, J AGR FOOD CHEM, V56, P642, DOI 10.1021/jf073113b
   Valcheva-Kuzmanova S, 2007, PLANT FOOD HUM NUTR, V62, P19, DOI 10.1007/s11130-006-0036-2
   Vrhovsek U, 2012, J FOOD COMPOS ANAL, V25, P9, DOI 10.1016/j.jfca.2011.04.015
   Vuong T, 2009, INT J OBESITY, V33, P1166, DOI 10.1038/ijo.2009.149
   Wang HB, 1999, J NAT PROD, V62, P294, DOI 10.1021/np980501m
   Wang J, 2002, J AGR FOOD CHEM, V50, P850, DOI 10.1021/jf010976a
   Wu XL, 2002, J NUTR, V132, P1865, DOI 10.1093/jn/132.7.1865
   Yang M, 2011, CURR MED CHEM, V18, P291, DOI 10.2174/092986711794088380
   Yi WG, 2006, J AGR FOOD CHEM, V54, P5651, DOI 10.1021/jf0531959
   Yousef GG, 2013, J AGR FOOD CHEM, V61, P4806, DOI 10.1021/jf400823s
NR 105
TC 181
Z9 206
U1 1
U2 205
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD OCT
PY 2013
VL 5
IS 4
BP 1518
EP 1528
DI 10.1016/j.jff.2013.08.015
PG 11
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA AN6VS
UT WOS:000340737100002
DA 2025-06-11
ER

PT J
AU Singleton, JR
   Smith, AG
   Marcus, RL
AF Singleton, J. Robinson
   Smith, A. Gordon
   Marcus, Robin L.
TI Exercise as Therapy for Diabetic and Prediabetic Neuropathy
SO CURRENT DIABETES REPORTS
LA English
DT Review
DE Diabetic neuropathy; Exercise; Metabolic syndrome; Human trials;
   Sedentary behavior; Actigraphy
ID LIFE-STYLE INTERVENTION; ALDOSE REDUCTASE INHIBITOR; ALPHA-LIPOIC ACID;
   PERIPHERAL NEUROPATHY; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; PAINFUL
   NEUROPATHY; ENERGY-EXPENDITURE; GLYCEMIC CONTROL; ACE-INHIBITOR
AB Length-dependent neuropathy is the most common and costly complication of diabetes and frequently causes injury primarily to small-diameter cutaneous nociceptive fibers. Not only persistent hyperglycemia but also metabolic, endocrine, and inflammatory effects of obesity and dyslipidemia appear to play an important role in the development of diabetic neuropathy. Rational therapies aimed at direct control of glucose or its increased entry into the polyol pathway, oxidative or nitrosative stress, advanced glycation end product formation or signaling, microvascular ischemia, or adipocyte-derived toxicity have each failed in human trials of diabetic neuropathy. Aerobic exercise produces salutary effects in many of these pathogenic pathways simultaneously and, in both animal models and human trials, has been shown to improve symptoms of neuropathy and promote re-growth of cutaneous small-diameter fibers. Behavioral reduction in periods of seated, awake inactivity produces multimodal metabolic benefits similar to exercise, and the two strategies when combined may offer sustained benefit to peripheral nerve function.
C1 [Singleton, J. Robinson; Smith, A. Gordon] Univ Utah, Dept Neurol, Salt Lake City, UT 84112 USA.
   [Marcus, Robin L.] Univ Utah, Dept Phys Therapy, Salt Lake City, UT USA.
C3 Utah System of Higher Education; University of Utah; Utah System of
   Higher Education; University of Utah
RP Singleton, JR (corresponding author), Univ Utah, Dept Neurol, Salt Lake City, UT 84112 USA.
EM rob.singleton@hsc.utah.edu
OI Marcus, Robin/0000-0003-1298-0141; , Tushar/0000-0002-8527-8719
FU NIH [NIH R01 DK064814]
FX All authors of this paper have funding from NIH that is supporting this
   work (NIH R01 DK064814).
CR Ahmed FN, 2006, ANN NY ACAD SCI, V1084, P481, DOI 10.1196/annals.1372.022
   Allet L, 2010, DIABETOLOGIA, V53, P458, DOI 10.1007/s00125-009-1592-4
   [Anonymous], 1995, ANN INTERN MED, V122, P561, DOI 10.7326/0003-4819-122-8-199504150-00001
   [Anonymous], NIH PUBL
   [Anonymous], J DIABETES COMPLICAT
   [Anonymous], COCHRANE DA IN PRESS
   Armstrong DG, 2004, DIABETES CARE, V27, P1980, DOI 10.2337/diacare.27.8.1980
   Balducci S, 2006, J DIABETES COMPLICAT, V20, P216, DOI 10.1016/j.jdiacomp.2005.07.005
   Barnes J, 2012, APPL PHYSIOL NUTR ME, V37, P540, DOI [10.1139/h2012-024, 10.1139/H2012-024]
   Bey L, 2003, J PHYSIOL-LONDON, V551, P673, DOI 10.1113/jphysiol.2003.045591
   Boyanovsky B, 2003, J BIOL CHEM, V278, P26992, DOI 10.1074/jbc.M301536200
   Callaghan B, 2013, ANN NEUROL, V74, P397, DOI 10.1002/ana.23986
   Cameron NE, 2001, DIABETOLOGIA, V44, P1161, DOI 10.1007/s001250100626
   Casanova-Molla J, 2012, PAIN, V153, P982, DOI 10.1016/j.pain.2012.01.021
   Chen YW, 2012, ANESTH ANALG, V114, P1330, DOI 10.1213/ANE.0b013e31824c4ed4
   Cheng HT, 2012, NEUROBIOL DIS, V45, P280, DOI 10.1016/j.nbd.2011.08.011
   Cooper JN, 2012, METABOLISM, V61, P1589, DOI 10.1016/j.metabol.2012.04.012
   Coppey LJ, 2006, DIABETES, V55, P341, DOI 10.2337/diabetes.55.02.06.db05-0885
   Costa LA, 2004, DIABETIC MED, V21, P252, DOI 10.1111/j.1464-5491.2004.01124.x
   Cruz NG, 2013, DIABETES RES CLIN PR, V99, P85, DOI 10.1016/j.diabres.2012.09.003
   Dauch JR, 2013, J NEUROINFLAMM, V10, DOI 10.1186/1742-2094-10-64
   Davidson EP, 2010, DIABETES-METAB RES, V26, P306, DOI 10.1002/dmrr.1088
   De Greef KP, 2011, PATIENT EDUC COUNS, V84, P275, DOI 10.1016/j.pec.2010.07.010
   Donnelly JE, 2009, MED SCI SPORT EXER, V41, P459, DOI 10.1249/MSS.0b013e3181949333
   Dunstan DW, 2012, DIABETES CARE, V35, P976, DOI 10.2337/dc11-1931
   Duvivier BMFM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055542
   Dyck PJ, 2007, DIABETES CARE, V30, P2619, DOI 10.2337/dc06-2479
   DYCK PJ, 1993, NEUROLOGY, V43, P817, DOI 10.1212/WNL.43.4.817
   Esenabhalu VE, 2003, ANTIOXID REDOX SIGN, V5, P147, DOI 10.1089/152308603764816505
   Gaede P, 2003, NEW ENGL J MED, V348, P383, DOI 10.1056/NEJMoa021778
   Gardiner PA, 2011, AM J PREV MED, V41, P174, DOI 10.1016/j.amepre.2011.03.020
   Gordois A, 2003, DIABETES CARE, V26, P1790, DOI 10.2337/diacare.26.6.1790
   Greene DA, 1999, NEUROLOGY, V53, P580, DOI 10.1212/WNL.53.3.580
   Griffin JW, 2008, GLIA, V56, P1518, DOI 10.1002/glia.20778
   Groover AL, 2013, PAIN, V154, P2658, DOI 10.1016/j.pain.2013.07.052
   Guilford BL, 2011, EXP DIABETES RES, DOI 10.1155/2011/848307
   GUY RJC, 1985, DIABETOLOGIA, V28, P131
   Hamilton MT, 2007, DIABETES, V56, P2655, DOI 10.2337/db07-0882
   Handsaker JC, 2016, DIABETIC MED, V33, P97, DOI 10.1111/dme.12841
   Handsaker JC, 2014, DIABETES CARE, V37, P3047, DOI 10.2337/dc14-0955
   Harrison M, 2009, J APPL PHYSIOL, V106, P943, DOI 10.1152/japplphysiol.91367.2008
   Healy GN, 2008, DIABETES CARE, V31, P369, DOI 10.2337/dc07-1795
   Huang HH, 2011, EXP DIABETES RES, DOI 10.1155/2011/481427
   Ismail-Beigi F, 2010, LANCET, V376, P419, DOI 10.1016/S0140-6736(10)60576-4
   Kennedy JM, 2005, DIABETES, V54, P830, DOI 10.2337/diabetes.54.3.830
   Kihara M, 2001, NEUROSCI LETT, V310, P81, DOI 10.1016/S0304-3940(01)02052-3
   Király MA, 2007, METABOLISM, V56, P732, DOI 10.1016/j.metabol.2006.12.022
   Kluding PM, 2015, PHYS THER, V95, P223, DOI 10.2522/ptj.20140108
   Knowler William C, 2002, N Engl J Med, V346, P393, DOI 10.1056/NEJMoa012512
   Koster A, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0037696
   Kozey-Keadle S, 2012, J OBES, V2012, DOI 10.1155/2012/282303
   Kozey-Keadle S, 2011, MED SCI SPORT EXER, V43, P1561, DOI 10.1249/MSS.0b013e31820ce174
   KRENTZ AJ, 1992, DIABETIC MED, V9, P463, DOI 10.1111/j.1464-5491.1992.tb01818.x
   Kruse RL, 2010, PHYS THER, V90, P1568, DOI 10.2522/ptj.20090362
   Lauria G, 2010, EUR J NEUROL, V17, P903, DOI 10.1111/j.1468-1331.2010.03023.x
   Lauria G, 2010, J PERIPHER NERV SYST, V15, P202, DOI 10.1111/j.1529-8027.2010.00271.x
   LeMaster JW, 2008, PHYS THER, V88, P1385, DOI 10.2522/ptj.20080019
   Lewis GF, 2002, ENDOCR REV, V23, P201, DOI 10.1210/er.23.2.201
   Lupachyk S, 2012, FREE RADICAL BIO MED, V52, P1255, DOI 10.1016/j.freeradbiomed.2012.01.029
   Lyden K, 2012, MED SCI SPORT EXER, V44, P2243, DOI 10.1249/MSS.0b013e318260c477
   Malik RA, 2005, DIABETOLOGIA, V48, P578, DOI 10.1007/s00125-004-1663-5
   Malik RA, 1998, LANCET, V352, P1978, DOI 10.1016/S0140-6736(98)02478-7
   Mojaddidi Moaz, 2005, Curr Diab Rep, V5, P417, DOI 10.1007/s11892-005-0048-6
   Morrison S, 2014, J DIABETES COMPLICAT, V28, P715, DOI 10.1016/j.jdiacomp.2014.04.007
   Nygaard H, 2009, APPL PHYSIOL NUTR ME, V34, P1087, DOI 10.1139/H09-110
   Obrosova IG, 2007, AM J PHYSIOL-ENDOC M, V293, pE1645, DOI 10.1152/ajpendo.00479.2007
   Obrosova IG, 2009, NEUROTHERAPEUTICS, V6, P638, DOI 10.1016/j.nurt.2009.07.004
   Oltman CL, 2005, AM J PHYSIOL-ENDOC M, V289, pE113, DOI 10.1152/ajpendo.00594.2004
   Orchard TJ, 2005, ANN INTERN MED, V142, P611, DOI 10.7326/0003-4819-142-8-200504190-00009
   PFEIFER MA, 1995, DIABETES, V44, P1355, DOI 10.2337/diabetes.44.12.1355
   Pleiner J, 2002, J CLIN ENDOCR METAB, V87, P2913, DOI 10.1210/jc.87.6.2913
   Polydefkis M, 2004, BRAIN, V127, P1606, DOI 10.1093/brain/awh175
   Pop-Busui R, 2009, J PERIPHER NERV SYST, V14, P1, DOI 10.1111/j.1529-8027.2009.00200.x
   Praet SFE, 2008, DIABETOLOGIA, V51, P736, DOI 10.1007/s00125-008-0950-y
   Selagzi H, 2008, J ENDOCRINOL INVEST, V31, P971, DOI 10.1007/BF03345634
   Sharma NK, 2010, PHYS THER, V90, P714, DOI 10.2522/ptj.20090168
   Simone DA, 1998, J NEUROSCI, V18, P8947
   Singleton JR, 2015, ANN NEUROL, V77, P146, DOI 10.1002/ana.24310
   Singleton JR, 2014, ANN CLIN TRANSL NEUR, V1, P844, DOI 10.1002/acn3.125
   Singleton JR, 2003, DIABETES, V52, P2867, DOI 10.2337/diabetes.52.12.2867
   Smith AG, 2013, J DIABETES COMPLICAT, V27, P436, DOI 10.1016/j.jdiacomp.2013.04.003
   Smith AG, 2006, DIABETES CARE, V29, P1294, DOI 10.2337/dc06-0224
   Smith AG, 2005, J NEUROL SCI, V228, P65, DOI 10.1016/j.jns.2004.09.032
   Stephens BR, 2011, METABOLISM, V60, P941, DOI 10.1016/j.metabol.2010.08.014
   STRAUB RH, 1994, DIABETES CARE, V17, P1290, DOI 10.2337/diacare.17.11.1290
   Streckmann F, 2014, SPORTS MED, V44, P1289, DOI 10.1007/s40279-014-0207-5
   Swartz AM, 2011, INT J BEHAV NUTR PHY, V8, DOI 10.1186/1479-5868-8-69
   Tesfaye S, 1996, DIABETOLOGIA, V39, P1377, DOI 10.1007/s001250050586
   Tesfaye S, 2009, CURR DIABETES REP, V9, P432, DOI 10.1007/s11892-009-0070-1
   Thomas PK, 1997, DIABETES, V46, pS54, DOI 10.2337/diab.46.2.S54
   Thorp AA, 2011, AM J PREV MED, V41, P207, DOI 10.1016/j.amepre.2011.05.004
   Tuomilehto J, 2001, INT J CLIN PRACT, V55, P380
   Vincent AM, 2005, FASEB J, V19, P638, DOI 10.1096/fj.04-2513fje
   Vincent AM, 2009, DIABETES, V58, P2376, DOI 10.2337/db09-0047
   Watcho P, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/268547
   Yagihashi S, 2001, BRAIN, V124, P2448, DOI 10.1093/brain/124.12.2448
   Yoo M, 2015, PAIN MED, V16, P1482, DOI 10.1111/pme.12743
   Ziegler D, 2004, DIABETIC MED, V21, P114, DOI 10.1111/j.1464-5491.2004.01109.x
   Ziegler D, 1997, DIABETES, V46, pS62, DOI 10.2337/diab.46.2.S62
NR 99
TC 40
Z9 45
U1 1
U2 20
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1534-4827
EI 1539-0829
J9 CURR DIABETES REP
JI Curr. Diabetes Rep.
PD DEC
PY 2015
VL 15
IS 12
AR 120
DI 10.1007/s11892-015-0682-6
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CZ0OY
UT WOS:000366806700018
PM 26538074
DA 2025-06-11
ER

PT J
AU Malnick, SDH
   Alin, P
   Somin, M
   Neuman, MG
AF Malnick, Stephen D. H.
   Alin, Pavel
   Somin, Marina
   Neuman, Manuela G.
TI Fatty Liver Disease-Alcoholic and Non-Alcoholic: Similar but Different
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE alcoholic steatohepatitis; nonalcoholic steatohepatitis; cytokines;
   microbiome
ID HEDGEHOG PATHWAY ACTIVATION; NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE;
   HEPATIC STEATOSIS; OXIDATIVE STRESS; UNITED-STATES; INTESTINAL
   PERMEABILITY; CARDIOVASCULAR-DISEASE; BACTERIAL OVERGROWTH; HISTOLOGIC
   FEATURES
AB In alcohol-induced liver disease (ALD) and in non-alcoholic fatty liver disease (NAFLD), there are abnormal accumulations of fat in the liver. This phenomenon may be related to excessive alcohol consumption, as well as the combination of alcohol consumption and medications. There is an evolution from simple steatosis to steatohepatitis, fibrosis and cirrhosis leading to hepatocellular carcinoma (HCC). Hepatic pathology is very similar regarding non-alcoholic fatty liver disease (NAFLD) and ALD. Initially, there is lipid accumulation in parenchyma and progression to lobular inflammation. The morphological changes in the liver mitochondria, perivenular and perisinusoidal fibrosis, and hepatocellular ballooning, apoptosis and necrosis and accumulation of fibrosis may lead to the development of cirrhosis and HCC. Medical history of ethanol consumption, laboratory markers of chronic ethanol intake, AST/ALT ratio on the one hand and features of the metabolic syndrome on the other hand, may help in estimating the contribution of alcohol intake and the metabolic syndrome, respectively, to liver steatosis.
C1 [Malnick, Stephen D. H.; Alin, Pavel; Somin, Marina] Affiliated Hebrew Univ, Kaplan Med Ctr, Dept Internal Med, IL-76100 Rehovot, Israel.
   [Neuman, Manuela G.] Univ Toronto, Temer Fac Med, Dept Pharmacol & Toxicol, Vitro Drug Safety & Biotechnol, M5G OA3, Toronto, ON, Canada.
C3 Hebrew University of Jerusalem; Kaplan Medical Center; University of
   Toronto
RP Malnick, SDH (corresponding author), Affiliated Hebrew Univ, Kaplan Med Ctr, Dept Internal Med, IL-76100 Rehovot, Israel.; Neuman, MG (corresponding author), Univ Toronto, Temer Fac Med, Dept Pharmacol & Toxicol, Vitro Drug Safety & Biotechnol, M5G OA3, Toronto, ON, Canada.
EM steve@stevemalnickmd.com; m_neuman@rogers.com
OI Malnick, Stephen/0000-0003-1865-8313
CR Abdul-Hai A, 2015, WORLD J HEPATOL, V7, P1679, DOI 10.4254/wjh.v7.i12.1679
   Åberg F, 2018, HEPATOLOGY, V67, P2141, DOI 10.1002/hep.29631
   Adams LA, 2015, HEPATOLOGY, V61, P1555, DOI 10.1002/hep.27662
   Ajmera V, 2018, CLIN GASTROENTEROL H, V16, P341, DOI [10.1016/j.cgh.2018.01.026, 10.1016/j.cgh.2017.11.040]
   Amarapurka D N, 2006, Ann Hepatol, V5, P30
   Angulo P, 1999, HEPATOLOGY, V30, P1356, DOI 10.1002/hep.510300604
   Angulo P, 2002, NEW ENGL J MED, V346, P1221, DOI 10.1038/nrdp.2015.80
   Ansaldo E, 2021, ANNU REV IMMUNOL, V39, P449, DOI 10.1146/annurev-immunol-093019-112348
   Anstee QM, 2013, NAT REV GASTRO HEPAT, V10, P330, DOI 10.1038/nrgastro.2013.41
   Araújo AR, 2018, LIVER INT, V38, P47, DOI 10.1111/liv.13643
   Armstrong MJ, 2010, NEW ENGL J MED, V363, P1185, DOI 10.1056/NEJMc1006581
   Armstrong MJ, 2016, LANCET, V387, P679, DOI 10.1016/S0140-6736(15)00803-X
   Aron-Wisnewsky J, 2020, NAT REV GASTRO HEPAT, V17, P279, DOI 10.1038/s41575-020-0269-9
   Artru F, 2020, J HEPATOL, V72, P1052, DOI 10.1016/j.jhep.2019.12.017
   Arun J, 2006, OBES SURG, V16, P1351, DOI 10.1381/096089206778663715
   Askgaard G, 2015, J HEPATOL, V62, P1061, DOI 10.1016/j.jhep.2014.12.005
   BACON BR, 1994, GASTROENTEROLOGY, V107, P1103, DOI 10.1016/0016-5085(94)90235-6
   Bajaj JS, 2019, NAT REV GASTRO HEPAT, V16, P235, DOI 10.1038/s41575-018-0099-1
   Ballestri S, 2016, J GASTROEN HEPATOL, V31, P936, DOI 10.1111/jgh.13264
   BARAONA E, 1986, GASTROENTEROLOGY, V90, P103, DOI 10.1016/0016-5085(86)90081-8
   Beste LA, 2015, GASTROENTEROLOGY, V149, P1471, DOI 10.1053/j.gastro.2015.07.056
   Blaya D, 2016, GUT, V65, P1535, DOI 10.1136/gutjnl-2015-311314
   BODE C, 1987, J HEPATOL, V4, P8, DOI 10.1016/S0168-8278(87)80003-X
   Boeckmans J, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9010037
   Bonkovsky HL, 1999, J HEPATOL, V31, P421, DOI 10.1016/S0168-8278(99)80032-4
   Boroumand P, 2020, J CELL SCI, V133, DOI 10.1242/jcs.238394
   Browning JD, 2004, HEPATOLOGY, V40, P1387, DOI 10.1002/hep.20466
   Brunt EM, 2010, WORLD J GASTROENTERO, V16, P5286, DOI 10.3748/wjg.v16.i42.5286
   Brunt EM, 2003, MODERN PATHOL, V16, P49, DOI 10.1097/01.MP.0000042420.21088.C7
   Calvert VS, 2007, HEPATOLOGY, V46, P166, DOI 10.1002/hep.21688
   Cameron RG, 1999, CLIN BIOCHEM, V32, P579, DOI 10.1016/S0009-9120(99)00058-2
   Carpino G, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-15943-z
   Carulli L, 2009, DIGEST LIVER DIS, V41, P823, DOI 10.1016/j.dld.2009.03.005
   Chalasani N, 2012, HEPATOLOGY, V55, P2005, DOI 10.1002/hep.25762
   Chang Y, 2020, CLIN GASTROENTEROL H, V18, P205, DOI 10.1016/j.cgh.2019.05.004
   Chang Y, 2019, AM J GASTROENTEROL, V114, P620, DOI 10.14309/ajg.0000000000000074
   Chang Y, 2019, GUT, V68, P1667, DOI 10.1136/gutjnl-2018-317666
   Chen KN, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0236977
   Chitturi S, 2002, HEPATOLOGY, V35, P373, DOI 10.1053/jhep.2002.30692
   Chitturi S, 2002, HEPATOLOGY, V36, P142, DOI 10.1053/jhep.2002.33892
   Chiu CC, 2017, NUTRIENTS, V9, DOI 10.3390/nu9111220
   Chu HK, 2020, J HEPATOL, V72, P391, DOI 10.1016/j.jhep.2019.09.029
   COHEN JA, 1979, DIGEST DIS SCI, V24, P835, DOI 10.1007/BF01324898
   Colmenero J, 2007, GASTROENTEROLOGY, V132, P687, DOI 10.1053/j.gastro.2006.12.036
   Cortez-Pinto H, 1999, CLIN NUTR, V18, P353, DOI 10.1016/S0261-5614(99)80015-6
   Couch RD, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0119362
   Crabb DW, 2020, HEPATOLOGY, V71, P306, DOI 10.1002/hep.30866
   Dam MK, 2013, SCAND J GASTROENTERO, V48, P585, DOI 10.3109/00365521.2013.777469
   Dantzer R, 2007, BRAIN BEHAV IMMUN, V21, P153, DOI 10.1016/j.bbi.2006.09.006
   Demir M, 2022, J HEPATOL, V76, P788, DOI 10.1016/j.jhep.2021.11.029
   DIEHL AM, 1988, GASTROENTEROLOGY, V95, P1056, DOI 10.1016/0016-5085(88)90183-7
   Diehl AM, 2002, ALCOHOL, V27, P7, DOI 10.1016/S0741-8329(02)00204-5
   Domenici FA, 2013, GENE, V529, P326, DOI 10.1016/j.gene.2013.06.091
   Dumitrascu Dan L, 2018, Clujul Med, V91, P147, DOI 10.15386/cjmed-993
   EASL, 2016, OBESITY FACTS, V9, P65, DOI [10.1159/000443344, 10.1007/s00125-016-3902-y, 10.1016/j.jhep.2015.11.004]
   Elshaghabee FMF, 2020, HEPATIC MED-EVID RES, V12, P93, DOI 10.2147/HMER.S254195
   Elshaghabee FMF, 2016, FRONT MICROBIOL, V7, DOI 10.3389/fmicb.2016.00047
   Eslam M, 2020, J HEPATOL, V73, P202, DOI 10.1016/j.jhep.2020.03.039
   Eslam M, 2020, GASTROENTEROLOGY, V158, P1999, DOI 10.1053/j.gastro.2019.11.312
   Eslam M, 2019, GASTROENTEROLOGY, V157, P590, DOI 10.1053/j.gastro.2019.05.064
   Farrell G, 2019, HEPATOLOGY, V69, P2241, DOI 10.1002/hep.30333
   FERRANNINI E, 1983, J CLIN INVEST, V72, P1737, DOI 10.1172/JCI111133
   Filipovic B, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222413219
   Fiorentino L, 2010, HEPATOLOGY, V51, P103, DOI 10.1002/hep.23250
   Fletcher LM, 2003, ALCOHOL, V30, P131, DOI 10.1016/S0741-8329(03)00128-9
   FRENCH SW, 1993, SEMIN LIVER DIS, V13, P154, DOI 10.1055/s-2007-1007346
   FREZZA M, 1990, NEW ENGL J MED, V322, P95, DOI 10.1056/NEJM199001113220205
   FUKUI H, 1991, J HEPATOL, V12, P162, DOI 10.1016/0168-8278(91)90933-3
   Gastaldelli A, 2007, GASTROENTEROLOGY, V133, P496, DOI 10.1053/j.gastro.2007.04.068
   George DK, 1998, GASTROENTEROLOGY, V114, P311, DOI 10.1016/S0016-5085(98)70482-2
   Gluszynska P, 2021, J CLIN MED, V10, DOI 10.3390/jcm10245721
   Goland S, 2006, J CLIN GASTROENTEROL, V40, P949, DOI 10.1097/01.mcg.0000225668.53673.e6
   Gonzalez A, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/1617805
   Gulyás G, 2020, J CELL SCI, V133, DOI 10.1242/jcs.237388
   Gupta A, 2020, NAT REV GASTRO HEPAT, V17, P655, DOI 10.1038/s41575-020-0341-5
   Guy CD, 2012, HEPATOLOGY, V55, P1711, DOI 10.1002/hep.25559
   Harford KA, 2011, P NUTR SOC, V70, P408, DOI 10.1017/S0029665111000565
   Heard KJ, 2008, NEW ENGL J MED, V359, P285, DOI 10.1056/NEJMct0708278
   Henao-Mejia J, 2012, NATURE, V482, P179, DOI 10.1038/nature10809
   Hock B, 2005, ADDICTION, V100, P1477, DOI 10.1111/j.1360-0443.2005.01216.x
   Hoyles L, 2018, NAT MED, V24, P1070, DOI 10.1038/s41591-018-0061-3
   Hua SM, 2021, DIABETIC MED, V38, DOI 10.1111/dme.14522
   Human Microbiome Project Consortium, 2012, Nature, V486, P207, DOI 10.1038/nature11234
   Janik M., 2015, SOUD LEK, V60, P7
   Jiang SX, 2021, CAN LIVER J, DOI 10.3138/canlivj-2021-0025
   Kaplowitz N, 2007, SEMIN LIVER DIS, V27, P367, DOI 10.1055/s-2007-991513
   Kessoku T, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.770986
   Kim HJ, 2004, ARCH INTERN MED, V164, P2169, DOI 10.1001/archinte.164.19.2169
   Kim JH, 2011, DIGESTION, V84, P149, DOI 10.1159/000326854
   Kleiner DE, 2012, SEMIN LIVER DIS, V32, P3, DOI 10.1055/s-0032-1306421
   Kowdley KV, 2012, HEPATOLOGY, V55, P77, DOI 10.1002/hep.24706
   KRAL JG, 1977, METABOLISM, V26, P1025, DOI 10.1016/0026-0495(77)90020-8
   Kumarendran B, 2018, PLOS MED, V15, DOI 10.1371/journal.pmed.1002542
   Latva-Rasku A, 2019, DIABETES CARE, V42, P931, DOI 10.2337/dc18-1569
   Lazo M, 2021, CLIN GASTROENTEROL H, V19, P2606, DOI 10.1016/j.cgh.2020.08.054
   Lazo M, 2013, AM J EPIDEMIOL, V178, P38, DOI 10.1093/aje/kws448
   Le Roy T, 2013, GUT, V62, P1787, DOI 10.1136/gutjnl-2012-303816
   Leclercq S, 2014, P NATL ACAD SCI USA, V111, pE4485, DOI 10.1073/pnas.1415174111
   Lee KH, 2006, CARCINOGENESIS, V27, P1398, DOI 10.1093/carcin/bgi337
   LEE RG, 1989, HUM PATHOL, V20, P594, DOI 10.1016/0046-8177(89)90249-9
   Lefkowitch Jay H, 2005, Clin Liver Dis, V9, P37, DOI 10.1016/j.cld.2004.11.001
   LELBACH WK, 1975, ANN NY ACAD SCI, V252, P85, DOI 10.1111/j.1749-6632.1975.tb19146.x
   Leoni S, 2018, WORLD J GASTROENTERO, V24, P3361, DOI 10.3748/wjg.v24.i30.3361
   Li S, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.01328
   Li Y, 2013, BIOMED REP, V1, P57, DOI 10.3892/br.2012.18
   Lieber C S, 1997, Adv Pharmacol, V38, P601
   LIN RS, 1995, J HEPATOL, V22, P165, DOI 10.1016/0168-8278(95)80424-2
   Lin YC, 2011, J PEDIATR-US, V158, P740, DOI 10.1016/j.jpeds.2010.11.016
   Llopis M, 2016, GUT, V65, P830, DOI 10.1136/gutjnl-2015-310585
   LUDWIG J, 1980, MAYO CLIN PROC, V55, P434
   Ma HY, 2020, J HEPATOL, V72, P946, DOI 10.1016/j.jhep.2019.12.016
   Machado MV, 2015, GUT, V64, P1148, DOI 10.1136/gutjnl-2014-307362
   Malnick SDH, 2021, BIOLOGY-BASEL, V10, DOI 10.3390/biology10050447
   Maor Y, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9020106
   Marchesini G, 2003, HEPATOLOGY, V37, P917, DOI 10.1053/jhep.2003.50161
   Masarone M, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/9547613
   Matteoni CA, 1999, GASTROENTEROLOGY, V116, P1413, DOI 10.1016/S0016-5085(99)70506-8
   McClain C, 2005, ALCOHOL CLIN EXP RES, V29, p180S, DOI 10.1097/01.alc.0000189276.34230.f5
   Mehal WZ, 2022, J HEPATOL, V76, P765, DOI 10.1016/j.jhep.2021.12.035
   Méndez-Sánchez N, 2022, LANCET GASTROENTEROL, V7, P388, DOI 10.1016/S2468-1253(22)00062-0
   Mendler MH, 1999, GASTROENTEROLOGY, V117, P1155, DOI 10.1016/S0016-5085(99)70401-4
   MEZEY E, 1975, AM J CLIN NUTR, V28, P1277, DOI 10.1093/ajcn/28.11.1277
   Minhas AMK, 2023, CURR PROB CARDIOLOGY, V48, DOI 10.1016/j.cpcardiol.2022.101199
   Mofrad P, 2003, HEPATOLOGY, V37, P1286, DOI 10.1053/jhep.2003.50229
   Morencos FC, 1996, DIGEST DIS SCI, V41, P552, DOI 10.1007/BF02282340
   Morley KC, 2018, EXPERT OPIN INV DRUG, V27, P667, DOI 10.1080/13543784.2018.1501471
   Mottin CC, 2004, OBES SURG, V14, P635, DOI 10.1381/096089204323093408
   MOUSSAVIAN SN, 1985, DIGEST DIS SCI, V30, P211
   Muntaner L, 2010, LIVER INT, V30, P1123, DOI 10.1111/j.1478-3231.2010.02287.x
   Muse ED, 2004, J CLIN INVEST, V114, P232, DOI 10.1172/JCI200421270
   Musso G, 2005, HEPATOLOGY, V42, P1175, DOI 10.1002/hep.20896
   Mutlu EA, 2012, AM J PHYSIOL-GASTR L, V302, pG966, DOI 10.1152/ajpgi.00380.2011
   Nair S, 2001, AM J GASTROENTEROL, V96, P1200, DOI 10.1111/j.1572-0241.2001.03702.x
   Nanji AA, 1997, HEPATOLOGY, V26, P1538, DOI 10.1002/hep.510260622
   Nascè A, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11061131
   Nelson JE, 2011, HEPATOLOGY, V53, P448, DOI 10.1002/hep.24038
   Neuman MG, 2022, CURR ISSUES MOL BIOL, V44, P1294, DOI 10.3390/cimb44030087
   Neuman MG, 2022, EXP MOL PATHOL, V126, DOI 10.1016/j.yexmp.2022.104750
   Neuman MG, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.678118
   Newsome PN, 2021, NEW ENGL J MED, V384, P1113, DOI 10.1056/NEJMoa2028395
   NIEMELA O, 1994, LAB INVEST, V70, P537
   Nier A, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030699
   Nobili V, 2006, EUR J ENDOCRINOL, V155, P735, DOI 10.1530/eje.1.02288
   Nyblom H, 2004, ALCOHOL ALCOHOLISM, V39, P336, DOI 10.1093/alcalc/agh074
   Pallayova M, 2014, CLIN OBES, V4, P243, DOI 10.1111/cob.12068
   Palmentieri B, 2006, DIGEST LIVER DIS, V38, P485, DOI 10.1016/j.dld.2006.03.021
   Parola M, 2001, J HEPATOL, V35, P297, DOI 10.1016/S0168-8278(01)00142-8
   Peery AF, 2015, GASTROENTEROLOGY, V149, P1731, DOI [10.1053/j.gastro.2015.08.045, 10.1053/j.gastro.2018.08.063]
   Petersen KF, 2010, NEW ENGL J MED, V362, P1082, DOI 10.1056/NEJMoa0907295
   Poulsen KL, 2021, JCI INSIGHT, V6, DOI 10.1172/jci.insight.141420
   POWELL EE, 1990, HEPATOLOGY, V11, P74, DOI 10.1002/hep.1840110114
   Powell EE, 2021, LANCET, V397, P2212, DOI 10.1016/S0140-6736(20)32511-3
   Puri P, 2018, HEPATOLOGY, V67, P1284, DOI 10.1002/hep.29623
   Purohit V, 2008, ALCOHOL, V42, P349, DOI 10.1016/j.alcohol.2008.03.131
   Rensen SS, 2009, HEPATOLOGY, V50, P1809, DOI 10.1002/hep.23228
   Rensen SS, 2009, AM J PATHOL, V175, P1473, DOI 10.2353/ajpath.2009.080999
   Roerecke M, 2016, EBIOMEDICINE, V8, P317, DOI 10.1016/j.ebiom.2016.04.023
   ROFSKY NM, 1995, SEMIN ULTRASOUND CT, V16, P16, DOI 10.1016/0887-2171(95)90012-8
   Ronis MJJ, 2005, FREE RADICAL BIO MED, V39, P619, DOI 10.1016/j.freeradbiomed.2005.04.011
   Rotman Y, 2010, HEPATOLOGY, V52, P894, DOI 10.1002/hep.23759
   RUBIN E, 1968, NEW ENGL J MED, V278, P869, DOI 10.1056/NEJM196804182781602
   Sampey BP, 2007, J BIOL CHEM, V282, P1925, DOI 10.1074/jbc.M610602200
   Sanyal AJ, 2001, GASTROENTEROLOGY, V120, P1183, DOI 10.1053/gast.2001.23256
   Sastre J, 2007, FRONT BIOSCI, V12, P1200, DOI 10.2741/2138
   SHERON N, 1993, HEPATOLOGY, V18, P41, DOI 10.1002/hep.1840180108
   Shiba S, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-93086-y
   Siddiqui MS, 2021, CLIN GASTROENTEROL H, V19, P2670, DOI 10.1016/j.cgh.2020.10.051
   Singal AK, 2018, AM J GASTROENTEROL, V113, P175, DOI 10.1038/ajg.2017.469
   Sookoian S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0058895
   Sookoian S, 2010, HEPATOLOGY, V52, P1992, DOI 10.1002/hep.23927
   Sorbi D, 1999, AM J GASTROENTEROL, V94, P1018
   Springer F, 2010, WORLD J GASTROENTERO, V16, P1560, DOI 10.3748/wjg.v16.i13.1560
   Sreekumar R, 2003, HEPATOLOGY, V38, P244, DOI 10.1053/jhep.2003.50290
   Stofan M, 2020, FRONT MED-LAUSANNE, V7, DOI 10.3389/fmed.2020.00544
   Sumida Y, 2013, HEPATO-GASTROENTEROL, V60, P1445, DOI 10.5754/hge11421
   Sun Q, 2017, BBA-GEN SUBJECTS, V1861, P2912, DOI 10.1016/j.bbagen.2016.09.009
   Sven MF, 2020, CONTEMP CLIN TRIALS, V98, DOI 10.1016/j.cct.2020.106170
   Tajiri K, 2009, EUR J GASTROEN HEPAT, V21, P673, DOI 10.1097/MEG.0b013e32831bc3d6
   TANGBARTON P, 1985, GASTROINTEST RADIOL, V10, P133, DOI 10.1007/BF01893087
   Tarantino G, 2020, DIAGNOSTICS, V10, DOI 10.3390/diagnostics10060395
   Targher G, 2016, J HEPATOL, V65, P589, DOI 10.1016/j.jhep.2016.05.013
   TELI MR, 1995, LANCET, V346, P987, DOI 10.1016/S0140-6736(95)91685-7
   Teschke R, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21010212
   Thapa Komal, 2021, Current Drug Discovery Technologies, V18, P333, DOI 10.2174/1570163817666200121143959
   THULUVATH P, 1994, ALCOHOL CLIN EXP RES, V18, P795, DOI 10.1111/j.1530-0277.1994.tb00042.x
   Torres JL, 2018, WORLD J GASTROENTERO, V24, P4104, DOI 10.3748/wjg.v24.i36.4104
   Traversy G, 2015, CURR OBES REP, V4, P122, DOI 10.1007/s13679-014-0129-4
   Turlin B, 2001, AM J CLIN PATHOL, V116, P263
   Valenti L, 2010, GASTROENTEROLOGY, V138, P905, DOI 10.1053/j.gastro.2009.11.013
   van der Poorten D, 2008, HEPATOLOGY, V48, P449, DOI 10.1002/hep.22350
   Van Meeteren MJW, 2020, EXPERT OPIN INV DRUG, V29, P117, DOI 10.1080/13543784.2020.1668375
   Van Melkebeke L, 2021, CURR OPIN PHARMACOL, V60, P91, DOI 10.1016/j.coph.2021.06.011
   Vancamelbeke M, 2017, EXPERT REV GASTROENT, V11, P821, DOI 10.1080/17474124.2017.1343143
   Viganò M, 2000, GASTROENTEROLOGY, V118, P986, DOI 10.1016/S0016-5085(00)70193-4
   Vilar-Gomez E, 2015, GASTROENTEROLOGY, V149, P367, DOI 10.1053/j.gastro.2015.04.005
   von Loeffelholz C, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9121853
   WALKER JEC, 1970, BIOCHEM J, V119, P511, DOI 10.1042/bj1190511
   Wang XL, 2021, GUT, V70, P784, DOI 10.1136/gutjnl-2020-322526
   Westman EC, 2007, AM J CLIN NUTR, V86, P276, DOI 10.1093/ajcn/86.2.276
   Wieckowska A, 2008, AM J GASTROENTEROL, V103, P1372, DOI 10.1111/j.1572-0241.2007.01774.x
   Williams CD, 2011, GASTROENTEROLOGY, V140, P124, DOI 10.1053/j.gastro.2010.09.038
   Willner IR, 2001, AM J GASTROENTEROL, V96, P2957
   Wong T, 2019, JAMA-J AM MED ASSOC, V321, P1723, DOI 10.1001/jama.2019.2276
   Wong VWS, 2012, GUT, V61, P409, DOI 10.1136/gutjnl-2011-300342
   Wortmann SB, 2019, J INHERIT METAB DIS, V42, P237, DOI 10.1002/jimd.12011
   Yang AM, 2017, J CLIN INVEST, V127, P2829, DOI 10.1172/JCI90562
   Yang YM, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020774
   You M, 2002, J BIOL CHEM, V277, P29342, DOI 10.1074/jbc.M202411200
   Younossi ZM, 1999, HEPATOLOGY, V30, P847, DOI 10.1002/hep.510300407
   Younossi ZM, 2019, LANCET, V394, P2184, DOI 10.1016/S0140-6736(19)33041-7
   Younossi ZM, 2019, CLIN GASTROENTEROL H, V17, P1625, DOI 10.1016/j.cgh.2018.11.033
   Younossi ZM, 2019, J HEPATOL, V70, P531, DOI 10.1016/j.jhep.2018.10.033
   Zelber-Sagi S, 2021, SEMIN LIVER DIS, V41, P248, DOI 10.1055/s-0041-1729971
   Zhang YZN, 2018, BRIT J RADIOL, V91, DOI 10.1259/bjr.20170959
   Zuo ZH, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.767584
NR 215
TC 40
Z9 42
U1 3
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2022
VL 23
IS 24
AR 16226
DI 10.3390/ijms232416226
PG 25
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 7E6TN
UT WOS:000901297800001
PM 36555867
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chiriac, S
   Stanciu, C
   Girleanu, I
   Cojocariu, C
   Sfarti, C
   Singeap, AM
   Cuciureanu, T
   Huiban, L
   Muzica, CM
   Zenovia, S
   Nastasa, R
   Trifan, A
AF Chiriac, Stefan
   Stanciu, Carol
   Girleanu, Irina
   Cojocariu, Camelia
   Sfarti, Catalin
   Singeap, Ana-Maria
   Cuciureanu, Tudor
   Huiban, Laura
   Muzica, Cristina Maria
   Zenovia, Sebastian
   Nastasa, Robert
   Trifan, Anca
TI Nonalcoholic Fatty Liver Disease and Cardiovascular Diseases: The Heart
   of the Matter
SO CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Review
ID GAMMA-GLUTAMYL-TRANSFERASE; INSULIN-RESISTANCE; LONG-TERM; SUBCLINICAL
   ATHEROSCLEROSIS; ADIPOSE-TISSUE; BLOOD-PRESSURE; FOLLOW-UP; ASSOCIATION;
   INCIDENT; RISK
AB Nonalcoholic fatty liver disease (NAFLD) has emerged as the most frequent cause of liver disease worldwide, comprising a plethora of conditions, ranging from steatosis to end-stage liver disease. Cardiovascular disease (CVD) has been associated with NAFLD and CVD-related events represent the main cause of death in patients with NAFLD, surpassing liver-related mortality. This association is not surprising as NAFLD has been considered a part of the metabolic syndrome and has been related to numerous CVD risk factors, namely, insulin resistance, abdominal obesity, dyslipidemia, hyperuricemia, chronic kidney disease, and type 2 diabetes. Moreover, both NAFLD and CVD present similar pathophysiological mechanisms, such as increased visceral adiposity, altered lipid metabolism, increased oxidative stress, and systemic inflammation that could explain their association. Whether NAFLD increases the risk for CVD or these diagnostic entities represent distinct manifestations of the metabolic syndrome has not yet been clarified. This review focuses on the relation between NAFLD and the spectrum of CVD, considering the pathophysiological mechanisms, risk factors, current evidence, and future directions.
C1 [Chiriac, Stefan; Girleanu, Irina; Cojocariu, Camelia; Sfarti, Catalin; Singeap, Ana-Maria; Cuciureanu, Tudor; Huiban, Laura; Muzica, Cristina Maria; Zenovia, Sebastian; Nastasa, Robert; Trifan, Anca] Grigore T Popa Univ Med & Pharm, Dept Gastroenterol, Iasi 700115, Romania.
   [Chiriac, Stefan; Stanciu, Carol; Girleanu, Irina; Cojocariu, Camelia; Sfarti, Catalin; Singeap, Ana-Maria; Trifan, Anca] St Spiridon Emergency Hosp, Inst Gastroenterol & Hepatol, Iasi 700111, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy
RP Girleanu, I (corresponding author), Grigore T Popa Univ Med & Pharm, Dept Gastroenterol, Iasi 700115, Romania.; Girleanu, I (corresponding author), St Spiridon Emergency Hosp, Inst Gastroenterol & Hepatol, Iasi 700111, Romania.
EM stefannchiriac@yahoo.com; stanciucarol@yahoo.com; gilda_iri25@yahoo.com;
   cameliacojocariu@yahoo.com; cvsfarti@gmail.com;
   anamaria.singeap@yahoo.com; drcuciureanutudor@gmail.com;
   huiban.laura@yahoo.com; lungu.christina@yahoo.com;
   sebastianzenovia20@gmail.com; nastasa.robert@yahoo.com;
   ancatrifan@yahoo.com
RI Girleanu, Irina/MTF-8711-2025; Muzica, Cristina/AAF-6801-2019;
   Sebastian, Zenovia/AAS-7256-2020; Cuciureanu, Tudor/MTF-6908-2025;
   Chiriac, Stefan/MTF-7600-2025; Trifan, Anca/MTF-7993-2025; Nastasa,
   Robert/AAR-6930-2021
OI Cojocariu, Camelia/0000-0001-6395-335X; Sebastian,
   Zenovia/0000-0003-0441-3980; Girleanu, Irina/0000-0001-5925-1232;
   Nastasa, Robert/0000-0002-8678-0663; Cristina-Maria,
   Muzica/0000-0003-0891-5961; Cuciureanu, Tudor/0000-0003-1550-8870;
   Trifan, Anca/0000-0001-9144-5520; Singeap,
   Ana-Maria/0000-0001-5621-548X; Chiriac, Stefan/0000-0003-2497-9236
CR Adams LA, 2017, GUT, V66, P1138, DOI 10.1136/gutjnl-2017-313884
   Agaç MT, 2013, ANGIOLOGY, V64, P604, DOI 10.1177/0003319713479155
   Agarwal A K, 2011, J Assoc Physicians India, V59, P351
   Akabame S, 2008, CIRC J, V72, P618
   Alexander M, 2019, BMJ-BRIT MED J, V367, DOI 10.1136/bmj.l5367
   Ampuero J, 2015, REV ESP ENFERM DIG, V107, P10
   Anstee QM, 2015, SEMIN LIVER DIS, V35, P270, DOI 10.1055/s-0035-1562947
   Aron-Wisnewsky J, 2020, NAT REV GASTRO HEPAT, V17, P279, DOI 10.1038/s41575-020-0269-9
   Arslan U, 2012, J CARDIOL, V60, P210, DOI 10.1016/j.jjcc.2012.05.003
   Baratta F, 2020, CLIN GASTROENTEROL H, V18, P2324, DOI 10.1016/j.cgh.2019.12.026
   Benhamed F, 2012, J CLIN INVEST, V122, P2176, DOI 10.1172/JCI41636
   Bertot LC, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17050774
   Bonapace S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0088371
   Bonnet F, 2017, J HYPERTENS, V35, P493, DOI 10.1097/HJH.0000000000001204
   Borén J, 2020, EUR HEART J, V41, P2313, DOI 10.1093/eurheartj/ehz962
   Brouwers MCGJ, 2020, DIABETOLOGIA, V63, P253, DOI 10.1007/s00125-019-05024-3
   Carnagarin R, 2019, BRIT J PHARMACOL, V176, P1839, DOI 10.1111/bph.14481
   Caussy C, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-09455-9
   Chan WK, 2014, CLIN RES HEPATOL GAS, V38, P284, DOI 10.1016/j.clinre.2014.02.009
   Chang Y, 2019, GUT, V68, P1667, DOI 10.1136/gutjnl-2018-317666
   Chen CH, 2010, DIGEST DIS SCI, V55, P1752, DOI 10.1007/s10620-009-0935-9
   Chiang CH, 2010, CLIN BIOCHEM, V43, P1399, DOI 10.1016/j.clinbiochem.2010.09.003
   Cho YK, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-30465-y
   Cusi K, 2012, GASTROENTEROLOGY, V142, P711, DOI 10.1053/j.gastro.2012.02.003
   Da Silva HE, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-19753-9
   Del Chierico F, 2017, HEPATOLOGY, V65, P451, DOI 10.1002/hep.28572
   Demir M, 2020, J GASTROEN HEPATOL, V35, P1969, DOI 10.1111/jgh.15071
   Després JP, 2012, CIRCULATION, V126, P1301, DOI 10.1161/CIRCULATIONAHA.111.067264
   Dongiovanni P, 2015, HEPATOLOGY, V61, P506, DOI 10.1002/hep.27490
   Ekstedt M, 2006, HEPATOLOGY, V44, P865, DOI 10.1002/hep.21327
   Ekstedt M, 2015, HEPATOLOGY, V61, P1547, DOI 10.1002/hep.27368
   Francque SM, 2016, J HEPATOL, V65, P425, DOI 10.1016/j.jhep.2016.04.005
   Fraser A, 2007, ARTERIOSCL THROM VAS, V27, P2729, DOI 10.1161/ATVBAHA.107.152298
   Gill C, 2017, AM J CARDIOL, V119, P1717, DOI 10.1016/j.amjcard.2017.03.010
   Goulopoulou S, 2016, PHARMACOL REV, V68, P142, DOI 10.1124/pr.114.010090
   Gruzdeva O, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.02163
   Henson JB, 2020, ALIMENT PHARM THER, V51, P728, DOI 10.1111/apt.15660
   Huh JH, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0143560
   Hwang DH, 2016, EUR J PHARMACOL, V785, P24, DOI 10.1016/j.ejphar.2016.04.024
   Käräjämäki AJ, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0142937
   Kasper P, 2021, CLIN RES CARDIOL, V110, P921, DOI 10.1007/s00392-020-01709-7
   Keskin M, 2017, AM J CARDIOL, V120, P1720, DOI 10.1016/j.amjcard.2017.07.107
   Khalid YS, 2020, AM J CARDIOVASC DIS, V10, P258
   Kim D, 2016, CLIN GASTROENTEROL H, V14, P132, DOI 10.1016/j.cgh.2015.07.024
   Kim D, 2013, HEPATOLOGY, V57, P1357, DOI 10.1002/hep.26156
   Koeth RA, 2019, J CLIN INVEST, V129, P373, DOI 10.1172/JCI94601
   Koo BK, 2020, J VASC SURG, V71, P204, DOI 10.1016/j.jvs.2019.03.044
   Korenblat KM, 2008, GASTROENTEROLOGY, V134, P1369, DOI 10.1053/j.gastro.2008.01.075
   Kozlitina J, 2014, NAT GENET, V46, P352, DOI 10.1038/ng.2901
   Lau K, 2010, J HYPERTENS, V28, P1829, DOI 10.1097/HJH.0b013e32833c211b
   Lauridsen BK, 2018, EUR HEART J, V39, P385, DOI 10.1093/eurheartj/ehx662
   Lazo Mariana, 2011, BMJ, V343, pd6891, DOI 10.1136/bmj.d6891
   Lechner K, 2020, METAB SYNDR RELAT D, V18, P176, DOI 10.1089/met.2019.0115
   Libby P, 2019, ARTERIOSCL THROM VAS, V39, P538, DOI 10.1161/ATVBAHA.118.310958
   Lin YC, 2005, WORLD J GASTROENTERO, V11, P4838, DOI 10.3748/wjg.v11.i31.4838
   Loomba R, 2019, HEPATOLOGY, V70, P1885, DOI 10.1002/hep.30946
   Lorbeer R, 2017, J HYPERTENS, V35, P737, DOI 10.1097/HJH.0000000000001245
   Ma JL, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01082
   Mantovani A, 2016, DIABETES CARE, V39, P1416, DOI 10.2337/dc16-0091
   Meex RCR, 2017, NAT REV ENDOCRINOL, V13, P508, DOI 10.1038/nrendo.2017.56
   Miele L., 2020, TRANSL RES
   Musso G, 2011, ANN MED, V43, P617, DOI 10.3109/07853890.2010.518623
   Narayan J, 2020, INT J HEPATOL, V2020, DOI 10.1155/2020/1825142
   Ong JP, 2008, J HEPATOL, V49, P608, DOI 10.1016/j.jhep.2008.06.018
   Oni E, 2019, AM J CARDIOL, V124, P534, DOI 10.1016/j.amjcard.2019.05.028
   Packer M, 2018, J AM COLL CARDIOL, V71, P2360, DOI 10.1016/j.jacc.2018.03.509
   Paik JM, 2019, HEPATOL COMMUN, V3, P1459, DOI 10.1002/hep4.1419
   Pal D, 2012, NAT MED, V18, P1279, DOI 10.1038/nm.2851
   Pastore A, 2014, INT J MOL SCI, V15, P21202, DOI 10.3390/ijms151121202
   Pastori D, 2020, MAYO CLIN PROC, V95, P513, DOI 10.1016/j.mayocp.2019.08.027
   Perera N, 2016, BMC CARDIOVASC DISOR, V16, DOI 10.1186/s12872-016-0212-8
   Perumpail BJ, 2017, WORLD J GASTROENTERO, V23, P8263, DOI 10.3748/wjg.v23.i47.8263
   Petersen MC, 2018, PHYSIOL REV, V98, P2133, DOI 10.1152/physrev.00063.2017
   de Carvalho SCR, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-37
   Ryoo JH, 2014, J GASTROEN HEPATOL, V29, P1926, DOI 10.1111/jgh.12643
   Scholz GH, 2016, VISC MED, V32, P319, DOI 10.1159/000450866
   Shulman GI, 2014, NEW ENGL J MED, V371, P1131, DOI 10.1056/NEJMra1011035
   Sinn DH, 2020, J GASTROEN HEPATOL, V35, P833, DOI 10.1111/jgh.14856
   Sinn DH, 2019, EUR J ENDOCRINOL, V181, P185, DOI 10.1530/EJE-19-0143
   Sinn DH, 2017, GUT, V66, P323, DOI 10.1136/gutjnl-2016-311854
   Stahl EP, 2019, J AM COLL CARDIOL, V73, P948, DOI 10.1016/j.jacc.2018.11.050
   Stefan N, 2019, LANCET DIABETES ENDO, V7, P313, DOI 10.1016/S2213-8587(18)30154-2
   Stefan N, 2013, NAT REV ENDOCRINOL, V9, P144, DOI 10.1038/nrendo.2012.258
   Stepanova M, 2012, CLIN GASTROENTEROL H, V10, P646, DOI 10.1016/j.cgh.2011.12.039
   Sung KC, 2014, J HEPATOL, V60, P1040, DOI 10.1016/j.jhep.2014.01.009
   Tang WHW, 2019, J AM COLL CARDIOL, V73, P2089, DOI 10.1016/j.jacc.2019.03.024
   Targher G, 2020, GUT, V69, P1691, DOI 10.1136/gutjnl-2020-320622
   Targher G, 2016, J HEPATOL, V65, P589, DOI 10.1016/j.jhep.2016.05.013
   Targher G, 2014, NUTR METAB CARDIOVAS, V24, P663, DOI 10.1016/j.numecd.2014.01.005
   Targher G, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057183
   Treeprasertsuk S, 2012, LIVER INT, V32, P945, DOI 10.1111/j.1478-3231.2011.02753.x
   Trépo E, 2016, J HEPATOL, V65, P399, DOI 10.1016/j.jhep.2016.03.011
   Tripodi A, 2014, J HEPATOL, V61, P148, DOI 10.1016/j.jhep.2014.03.013
   Tsaban G, 2017, AM J CLIN NUTR, V106, P984, DOI 10.3945/ajcn.117.157115
   Vilar-Gomez E, 2018, GASTROENTEROLOGY, V155, P443, DOI 10.1053/j.gastro.2018.04.034
   Wang CCL, 2016, CIRCULATION, V133, P2459, DOI 10.1161/CIRCULATIONAHA.116.022194
   White MG, 2016, DIABETES CARE, V39, P2080, DOI 10.2337/dc16-0619
   Wong Carrie R, 2018, Clin Liver Dis (Hoboken), V12, P39, DOI 10.1002/cld.721
   Wu C.-K., 2019, EUROPEAN J GASTROENT
   Wu RN, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-09851-5
   Wu S., 2016, Sci. Rep., V6, P1
   Xin ZJ, 2020, LIVER INT, V40, P806, DOI 10.1111/liv.14322
   Xu PX, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-38305-9
   Yoshitaka H, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000006712
   Younossi ZM, 2019, J HEPATOL, V70, P531, DOI 10.1016/j.jhep.2018.10.033
   Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431
   Zewinger S, 2020, NAT IMMUNOL, V21, P30, DOI 10.1038/s41590-019-0548-1
   Zhao YC, 2020, HYPERTENSION, V75, P275, DOI 10.1161/HYPERTENSIONAHA.119.13419
   Zheng J, 2018, INT J MOL SCI, V18, P1
   Zheng RJ, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0913-3
   Zhou YY, 2018, HEPATOL COMMUN, V2, P376, DOI 10.1002/hep4.1155
NR 111
TC 26
Z9 26
U1 0
U2 13
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2291-2789
EI 2291-2797
J9 CAN J GASTROENTEROL
JI Can. J. Gastroenterol. Hepatol.
PD JAN 12
PY 2021
VL 2021
AR 6696857
DI 10.1155/2021/6696857
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA PZ9EE
UT WOS:000613049700002
PM 33505944
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Striegel, RH
   Bedrosian, R
   Wang, C
   Schwartz, S
AF Striegel, Ruth H.
   Bedrosian, Richard
   Wang, Chun
   Schwartz, Steven
TI Why Men Should Be Included in Research on Binge Eating: Results from a
   Comparison of Psychosocial Impairment in Men and Women
SO INTERNATIONAL JOURNAL OF EATING DISORDERS
LA English
DT Article
DE eating disorders; binge eating; obesity; metabolic syndrome; work
   productivity impairment; psychosocial impairment
ID GUIDED SELF-HELP; DISORDER SYMPTOMS; COMMUNITY SAMPLE; YOUNG-ADULTS;
   COMORBIDITY; PREVALENCE; VALIDITY; REPLICATION; DEPRESSION; OVERWEIGHT
AB Objective: Prevalence of binge eating has been shown to be as common in men as in women, yet few studies have included men. Men are especially underrepresented in treatment studies, raising the question of whether men who binge eat experience less distress or impairment than women. This study compared demographic and clinical correlates of binge eating in a large employee sample of men and women.
   Method: Cross-sectional data from 21,743 men and 24,608 women who participated in a health risk self assessment screening were used. Group differences in obesity, hypertension, dyslipidemia, Type 2 diabetes, depression, stress, sleep, sick days, work impairment, and non-work activity impairment were tested using chi-square tests (categorical variables) and independent sample t-tests (continuous variables).
   Results: Effect size estimates indicate that men (n = 1,630) and women (n = 2,754) who binge eat experience comparable levels of clinical impairment. They also report substantially greater impairment when compared with men and women who do not binge eat.
   Discussion: The underrepresentation of men in treatment-seeking samples does not appear to reflect lower levels of impairment in men versus women. Efforts are needed to raise awareness of the clinical significance of binge eating in men so that this group can receive appropriate screening and treatment services. (C) 2011 by Wiley Periodicals, Inc.
C1 [Striegel, Ruth H.] Wesleyan Univ, Dept Psychol, Middletown, CT 06459 USA.
   [Bedrosian, Richard; Wang, Chun; Schwartz, Steven] HealthMedia Inc, Ann Arbor, MI USA.
C3 Wesleyan University
RP Striegel, RH (corresponding author), Wesleyan Univ, Dept Psychol, 207 High St, Middletown, CT 06459 USA.
EM rstriegel@wesleyan.edu
OI Weissman, Ruth Striegel/0000-0001-6121-4641
FU HealthMedia, Inc.
FX Dr. Striegel-Moore was compensated by HealthMedia, Inc. for her work on
   this study. Drs. Bedrosian, Wang, and Schwartz are employees of
   HealthMedia, Inc.
CR Bedrosian RC, 2011, INT J EAT DISORDER, V44, P639, DOI 10.1002/eat.20844
   Brownley KA, 2007, INT J EAT DISORDER, V40, P337, DOI 10.1002/eat.20370
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   DeBar LL, 2011, PSYCHIAT SERV, V62, P367, DOI 10.1176/ps.62.4.pss6204_0367
   Debar LL, 2009, CONTEMP CLIN TRIALS, V30, P326, DOI 10.1016/j.cct.2009.02.007
   Dickerson JF, 2011, INT J EAT DISORDER, V44, P524, DOI 10.1002/eat.20842
   Grilo CM, 2009, INT J EAT DISORDER, V42, P228, DOI 10.1002/eat.20599
   Hudson JI, 2007, BIOL PSYCHIAT, V61, P348, DOI 10.1016/j.biopsych.2006.03.040
   Hudson JI, 2010, AM J CLIN NUTR, V91, P1568, DOI 10.3945/ajcn.2010.29203
   Kraemer HC, 2003, J AM ACAD CHILD PSY, V42, P1524, DOI 10.1097/00004583-200312000-00022
   Lewinsohn PM, 2002, INT J EAT DISORDER, V32, P426, DOI 10.1002/eat.10103
   Marcus MD, 2009, INT J EAT DISORDER, V42, P739, DOI 10.1002/eat.20725
   Mond JM, 2007, INT J EAT DISORDER, V40, P391, DOI 10.1002/eat.20380
   Mond JM, 2009, OBESITY, V17, P1627, DOI 10.1038/oby.2009.27
   Mond JM, 2009, J WOMENS HEALTH, V18, P1081, DOI 10.1089/jwh.2008.1174
   Perez M, 2011, OBESITY SILVER SPRIN
   RADLOFF LS, 1979, J ABNORM PSYCHOL, V88, P174, DOI 10.1037/0021-843X.88.2.174
   REILLY MC, 1993, PHARMACOECONOMICS, V4, P353, DOI 10.2165/00019053-199304050-00006
   Roberto CA, 2010, INT J EAT DISORDER, V43, P724, DOI 10.1002/eat.20770
   Smith DE, 1998, ANN BEHAV MED, V20, P227, DOI 10.1007/BF02884965
   Striegel-Moore RH, 2000, INT J EAT DISORDER, V27, P381
   Striegel-Moore RH, 2010, J CONSULT CLIN PSYCH, V78, P312, DOI 10.1037/a0018915
   Striegel-Moore RH, 2009, INT J EAT DISORDER, V42, P471, DOI 10.1002/eat.20625
   Wilson GT, 2010, ARCH GEN PSYCHIAT, V67, P94, DOI 10.1001/archgenpsychiatry.2009.170
   Wilson GT, 2009, INT J EAT DISORDER, V42, P603, DOI 10.1002/eat.20726
   Wolfe BE, 2009, INT J EAT DISORDER, V42, P674, DOI 10.1002/eat.20728
   Wonderlich SA, 2009, INT J EAT DISORDER, V42, P687, DOI 10.1002/eat.20719
NR 27
TC 129
Z9 151
U1 0
U2 32
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0276-3478
J9 INT J EAT DISORDER
JI Int. J. Eating Disord.
PD MAR
PY 2012
VL 45
IS 2
BP 233
EP 240
DI 10.1002/eat.20962
PG 8
WC Psychology, Clinical; Nutrition & Dietetics; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Nutrition & Dietetics; Psychiatry
GA 904WB
UT WOS:000301228500009
PM 22031213
DA 2025-06-11
ER

PT J
AU Chaabene, H
   Ramirez-Campillo, R
   Moran, J
   Schega, L
   Prieske, O
   Sandau, I
   Negra, Y
   Behrens, M
AF Chaabene, Helmi
   Ramirez-Campillo, Rodrigo
   Moran, Jason
   Schega, Lutz
   Prieske, Olaf
   Sandau, Ingo
   Negra, Yassine
   Behrens, Martin
TI The Era of Resistance Training as a Primary Form of Physical Activity
   for Physical Fitness and Health in Youth Has Come
SO SPORTS MEDICINE
LA English
DT Article; Early Access
ID BONE-MINERAL DENSITY; SKELETAL-MUSCLE HYPERTROPHY; RISK BEHAVIOR
   SURVEILLANCE; SPORTS-RELATED INJURIES; POSITION STATEMENT; AEROBIC
   EXERCISE; MUSCULAR FITNESS; BODY-COMPOSITION; CARDIORESPIRATORY FITNESS;
   CARDIOMETABOLIC RISK
AB Resistance training (RT) is widely regarded as the gold standard approach for enhancing muscular fitness (i.e., muscle strength, power, and muscular endurance) in youth while also providing health and physical fitness benefits traditionally associated with aerobic training (e.g., enhanced cardiorespiratory fitness, reduced body fat, improved insulin sensitivity). Additionally, while bone health can be improved following RT (particularly after plyometric jump training), aerobic training may result in a lesser or even neutral impact on bone mineral density enhancement (e.g., swimming). Regarding mental health and cognition, while aerobic training has well-established positive effects, preliminary evidence in obese youth suggests that RT may offer greater benefits in certain aspects compared to aerobic training. Additionally, RT can reduce the risk and incidence of injuries in youth. Overall, we argue in this Current Opinion article that the current consideration of RT as an additional, rather than essential (possibly even the most essential), aspect of physical activity in current national and international guidelines needs to be reconsidered. Overall, there is an urgent need to inform relevant stakeholders that, while aerobic activities remain essential, the next generation of physical activity guidelines should place greater emphasis on the particular importance of RT, providing more comprehensive guidance on its implementation for youth.
C1 [Chaabene, Helmi; Schega, Lutz] Otto von Guericke Univ, Chair Hlth & Phys Act, Dept Sport Sci, Magdeburg, Germany.
   [Chaabene, Helmi] Univ Jendouba, Inst Super Sport & Educ Phys Kef, Le Kef 7100, Tunisia.
   [Ramirez-Campillo, Rodrigo] Univ Andres Bello, Exercise & Rehabil Sci Inst, Fac Rehabil Sci, Sch Phys Therapy, Santiago 7591538, Chile.
   [Ramirez-Campillo, Rodrigo] Univ Tarapaca, Sport Sci & Human Performance Labs, Inst Alta Invest, Arica, Chile.
   [Moran, Jason] Univ Essex, Sch Sport Rehabil & Exercise Sci, Colchester, Essex, England.
   [Prieske, Olaf; Behrens, Martin] Univ Appl Sci Sport & Management Potsdam, Olymp Weg 7, D-14471 Potsdam, Germany.
   [Sandau, Ingo] Inst Appl Training Sci, Dept Strength Power & Tech Sports, Leipzig, Germany.
   [Negra, Yassine] Univ Manouba, Higher Inst Sport & Phys Educ Ksar Said, Res Unit UR17JS01 Sports Performance Hlth & Soc, La Manouba 2010, Tunisia.
   [Behrens, Martin] Rostock Univ, Med Ctr, Dept Orthopaed, Rostock, Germany.
C3 Otto von Guericke University; Universite de Jendouba; Universidad Andres
   Bello; Universidad de Tarapaca; University of Essex; Universite de la
   Manouba; University of Rostock
RP Chaabene, H (corresponding author), Otto von Guericke Univ, Chair Hlth & Phys Act, Dept Sport Sci, Magdeburg, Germany.; Chaabene, H (corresponding author), Univ Jendouba, Inst Super Sport & Educ Phys Kef, Le Kef 7100, Tunisia.
EM helmi.chaabane@ovgu.de
RI Negra, yassine/AAR-4942-2020; Ramirez-Campillo, Rodrigo/M-1258-2016;
   Prieske, Olaf/J-5221-2019; Behrens, Martin/H-8443-2019; Sandau,
   Ingo/LCD-9102-2024; Chaabene, Helmi/I-7317-2019
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL.
CR Aring;berg ND, 2015, STROKE, V46, P1769, DOI 10.1161/STROKEAHA.115.009008
   Abernethy L, 2007, BRIT J SPORT MED, V41, P627, DOI 10.1136/bjsm.2007.035691
   Agostinete RR, 2017, PEDIATR EXERC SCI, V29, P520, DOI 10.1123/pes.2017-0008
   Alberga AS, 2016, APPL PHYSIOL NUTR ME, V41, P255, DOI 10.1139/apnm-2015-0413
   Alves AR, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18105344
   Alves AR, 2016, J STRENGTH COND RES, V30, P2019, DOI 10.1519/JSC.0000000000001294
   [Anonymous], 1995, Bull World Health Organ, V73, P135
   [Anonymous], 1983, Phys Sportsmed, V11, P157, DOI 10.1080/00913847.1983.11708490
   Artero EG, 2011, PEDIATR DIABETES, V12, P704, DOI 10.1111/j.1399-5448.2011.00769.x
   Assunçao AR, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0160650
   Bassett DR, 2000, MED SCI SPORT EXER, V32, P70, DOI 10.1097/00005768-200001000-00012
   Baxter-Jones ADG, 2008, BONE, V43, P1101, DOI 10.1016/j.bone.2008.07.245
   Behm DG, 2008, APPL PHYSIOL NUTR ME, V33, P547, DOI 10.1139/H08-020
   Behringer M, 2014, J BONE MINER RES, V29, P467, DOI 10.1002/jbmr.2036
   Behringer M, 2010, PEDIATRICS, V126, pE1199, DOI 10.1542/peds.2010-0445
   Bellew James W, 2006, Pediatr Phys Ther, V18, P19, DOI 10.1097/01.pep.0000200952.63544.16
   Blakeley CE, 2018, BMC PEDIATR, V18, DOI 10.1186/s12887-018-0998-x
   Bloomfield SA., 2004, Med Sci Sports Exerc, V195, P3611
   Boreham C, 2001, J SPORT SCI, V19, P915, DOI 10.1080/026404101317108426
   Bouamra M, 2022, FRONT PHYSIOL, V13, DOI 10.3389/fphys.2022.869063
   Bouguezzi R, 2020, J STRENGTH COND RES, V34, P1609, DOI 10.1519/JSC.0000000000002486
   Brellenthin AG, 2022, CURR SPORT MED REP, V21, P272, DOI 10.1249/JSR.0000000000000981
   Bright TE, 2023, SPORTS MED, V53, P1219, DOI 10.1007/s40279-023-01843-y
   Bull FC, 2020, BRIT J SPORT MED, V54, P1451, DOI 10.1136/bjsports-2020-102955
   Burns RD, 2023, PREV MED, V177, DOI 10.1016/j.ypmed.2023.107750
   Burrows M, 2003, BRIT J SPORT MED, V37, P67, DOI 10.1136/bjsm.37.1.67
   CASPERSEN CJ, 1985, PUBLIC HEALTH REP, V100, P126
   Castro-Piñero J, 2019, J PEDIATR-US, V206, P134, DOI 10.1016/j.jpeds.2018.10.026
   Chaabene H., 2020, Sports Orthop Traumatol, V36, P231, DOI [10.1016/j.orthtr.2020.05.001, DOI 10.1016/J.ORTHTR.2020.05.001]
   Chaabene H, 2021, INT J SPORT PHYSIOL, V16, P1439, DOI 10.1123/ijspp.2020-0765
   Chaabene H, 2020, INT J SPORT PHYSIOL, V15, P91, DOI 10.1123/ijspp.2019-0005
   Chaabene H, 2021, J STRENGTH COND RES, V35, P2230, DOI 10.1519/JSC.0000000000003128
   Chan DCC, 2008, OSTEOPOROSIS INT, V19, P1485, DOI 10.1007/s00198-008-0595-1
   Cheval B, 2021, EXERC SPORT SCI REV, V49, P168, DOI 10.1249/JES.0000000000000252
   Chiang HL, 2024, JAMA PEDIATR, V178, P595, DOI 10.1001/jamapediatrics.2024.0806
   Clark EM, 2006, J BONE MINER RES, V21, P1489, DOI 10.1359/JBMR.060601
   Collard DCM, 2010, ARCH PEDIAT ADOL MED, V164, P145, DOI 10.1001/archpediatrics.2009.256
   Collins H, 2019, SPORTS MED-OPEN, V5, DOI 10.1186/s40798-019-0188-x
   Cooper C, 2011, OSTEOPOROSIS INT, V22, P1277, DOI 10.1007/s00198-011-1601-6
   Cormie P, 2011, SPORTS MED, V41, P17, DOI 10.2165/11537690-000000000-00000
   Costigan SA, 2016, MED SCI SPORT EXER, V48, P1985, DOI 10.1249/MSS.0000000000000993
   Courant F, 2010, J CLIN ENDOCR METAB, V95, P82, DOI 10.1210/jc.2009-1140
   Dâmaso AR, 2014, J SPORT SCI, V32, P1435, DOI 10.1080/02640414.2014.900692
   de Lima TR, 2022, SPORTS MED, V52, P1555, DOI 10.1007/s40279-021-01631-6
   De Meester A, 2018, J SCI MED SPORT, V21, P58, DOI 10.1016/j.jsams.2017.05.007
   Painelli V, 2023, J SCI SPORT EXERC, DOI 10.1007/s42978-023-00251-y
   Dias I, 2015, MED SCI SPORT EXER, V47, P2636, DOI 10.1249/MSS.0000000000000705
   Dooley FL, 2020, SPORTS MED, V50, P1129, DOI 10.1007/s40279-020-01265-0
   Duarte MAD Jr, 2024, ACTA PAEDIATR, V113, P1059, DOI 10.1111/apa.17126
   Duchateau J, 2023, EXERC SPORT SCI REV, V51, P117, DOI 10.1249/JES.0000000000000320
   Cohen DD, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0093150
   Eather N, 2016, PSYCHOL SPORT EXERC, V26, P14, DOI 10.1016/j.psychsport.2016.05.008
   Eaton Danice K., 2008, Morbidity and Mortality Weekly Report, V57, P1
   Ekkekakis P, 2006, INT J OBESITY, V30, P652, DOI 10.1038/sj.ijo.0803052
   Eliakim A, 1997, J BONE MINER RES, V12, P1708, DOI 10.1359/jbmr.1997.12.10.1708
   Emery CA, 2003, CLIN J SPORT MED, V13, P256, DOI 10.1097/00042752-200307000-00011
   Emery CA, 2022, J ORTHOP SPORT PHYS, V52, P40, DOI 10.2519/jospt.2022.10959
   Emery CA, 2015, BRIT J SPORT MED, V49, P865, DOI 10.1136/bjsports-2015-094639
   EPSTEIN LH, 1995, HEALTH PSYCHOL, V14, P109, DOI 10.1037/0278-6133.14.2.109
   Faigenbaum AD, 2010, BRIT J SPORT MED, V44, P56, DOI 10.1136/bjsm.2009.068098
   Faigenbaum AD, 2002, RES Q EXERCISE SPORT, V73, P416, DOI 10.1080/02701367.2002.10609041
   Faigenbaum AD, 2023, CURR SPORT MED REP, V22, P414, DOI 10.1249/JSR.0000000000001122
   Faigenbaum AD, 2022, BRIT J SPORT MED, V56, P997, DOI 10.1136/bjsports-2022-105804
   Faigenbaum AD, 2019, J SCI SPORT EXERC, V1, P208, DOI 10.1007/s42978-019-00038-0
   Faigenbaum AD, 2020, CURR SPORT MED REP, V19, P530, DOI 10.1249/JSR.0000000000000784
   Faigenbaum AD, 2017, ACSMS HEALTH FIT J, V21, P18, DOI 10.1249/FIT.0000000000000312
   Faigenbaum AD, 2017, ACTA PAEDIATR, V106, P696, DOI 10.1111/apa.13797
   Faigenbaum AD, 2016, BRIT J SPORT MED, V50, DOI 10.1136/bjsports-2015-094621
   Faigenbaum AD, 2013, PEDIATR EXERC SCI, V25, P591, DOI 10.1123/pes.25.4.591
   Faigenbaum AD, 2010, CURR SPORT MED REP, V9, P161, DOI 10.1249/JSR.0b013e3181de1214
   Faigenbaum AD, 2009, J STRENGTH COND RES, V23, pS60, DOI 10.1519/JSC.0b013e31819df407
   Fraser BJ, 2022, MED SCI SPORT EXER, V54, P1911, DOI 10.1249/MSS.0000000000002990
   Fraser BJ, 2021, J SCI MED SPORT, V24, P696, DOI 10.1016/j.jsams.2021.01.011
   Fraser BJ, 2017, J SCI MED SPORT, V20, P927, DOI 10.1016/j.jsams.2017.03.021
   Frisch A, 2009, BRIT MED BULL, V92, P95, DOI 10.1093/bmb/ldp034
   Fukunaga Tetsuo, 1992, Annals of Physiological Anthropology, V11, P357
   Gäbler M, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01057
   Garber CE, 2011, MED SCI SPORT EXER, V43, P1334, DOI 10.1249/MSS.0b013e318213fefb
   García-Hermoso A, 2023, JAMA PEDIATR, V177, P1276, DOI 10.1001/jamapediatrics.2023.4038
   Garcia-Hermoso A, 2023, BRIT J SPORT MED, V57, P225, DOI 10.1136/bjsports-2022-106189
   García-Hermoso A, 2022, TRANSL PEDIATR, V11, P474, DOI 10.21037/tp-21-507
   García-Hermoso A, 2019, SPORTS MED, V49, P1079, DOI 10.1007/s40279-019-01098-6
   Gaya AR, 2020, J HUM SPORT EXERC, V15, P549, DOI 10.14198/jhse.2020.153.07
   Goldfield GS, 2017, APPL PHYSIOL NUTR ME, V42, P361, DOI 10.1139/apnm-2016-0386
   Goldfield GS, 2015, J CONSULT CLIN PSYCH, V83, P1123, DOI 10.1037/ccp0000038
   Gomes TN, 2017, AM J HUM BIOL, V29, DOI 10.1002/ajhb.22904
   Gómez-Bruton A, 2017, WORLD J PEDIATR, V13, P112, DOI 10.1007/s12519-016-0076-0
   Gordon RJ, 2020, CLIN OBSTET GYNECOL, V63, P504, DOI 10.1097/GRF.0000000000000548
   Gralla MH, 2019, AM J LIFESTYLE MED, V13, P61, DOI 10.1177/1559827615624417
   Granacher U, 2011, INT J SPORTS MED, V32, P357, DOI 10.1055/s-0031-1271677
   Grontved A, 2013, DIABETES CARE, V36, P2575, DOI 10.2337/dc12-2252
   Gunter KB, 2012, EXERC SPORT SCI REV, V40, P13, DOI 10.1097/JES.0b013e318236e5ee
   Guthold R, 2020, LANCET CHILD ADOLESC, V4, P23, DOI 10.1016/S2352-4642(19)30323-2
   Guy J A, 2001, J Am Acad Orthop Surg, V9, P29
   Hallal PC, 2012, LANCET, V380, P247, DOI 10.1016/S0140-6736(12)60646-1
   Hamill BP., 1994, J STRENGTH COND RES, V8, P53, DOI 10.1519/1533-4287(1994)008andlt
   Harber MP, 2012, J APPL PHYSIOL, V113, P1495, DOI 10.1152/japplphysiol.00786.2012
   Heaney RP, 2000, OSTEOPOROSIS INT, V11, P985, DOI 10.1007/s001980070020
   HEINONEN A, 1993, BONE MINER, V23, P1, DOI 10.1016/S0169-6009(08)80086-4
   Henriksson H, 2019, BRIT J SPORT MED, V53, P1221, DOI 10.1136/bjsports-2017-098723
   Herbst KL, 2004, CURR OPIN CLIN NUTR, V7, P271, DOI 10.1097/00075197-200405000-00006
   Hernandez CJ, 2003, OSTEOPOROSIS INT, V14, P843, DOI 10.1007/s00198-003-1454-8
   Holtebekk ME, 2013, PEDIATR PHYS THER, V25, P415, DOI 10.1097/PEP.0b013e3182a635f0
   Huotari P, 2011, J SPORT SCI, V29, P1135, DOI 10.1080/02640414.2011.585166
   Hussey J, 2007, BRIT J SPORT MED, V41, P311, DOI 10.1136/bjsm.2006.032045
   Hyde ET, 2022, RES Q EXERCISE SPORT, V93, P728, DOI 10.1080/02701367.2021.1914303
   Inoue DS, 2015, J DIABETES COMPLICAT, V29, P258, DOI 10.1016/j.jdiacomp.2014.11.002
   Ishikawa S, 2013, SPORTS MED, V43, P875, DOI 10.1007/s40279-013-0060-y
   Jaworska N, 2019, EARLY INTERV PSYCHIA, V13, P128, DOI 10.1111/eip.12537
   Jones AM, 2000, SPORTS MED, V29, P373, DOI 10.2165/00007256-200029060-00001
   KANEHISA H, 1995, INT J SPORTS MED, V16, P54, DOI 10.1055/s-2007-972964
   이종도, 2006, [Journal of Korean Physical Education Association for Girls and Women, 한국여성체육학회지], V20, P37
   Kaster T, 2020, J SPORT SCI, V38, P1913, DOI 10.1080/02640414.2020.1763764
   Kim JH, 2016, NUTR RES, V36, P1423, DOI 10.1016/j.nutres.2016.09.013
   Kim S, 2015, OBES RES CLIN PRACT, V9, P125, DOI 10.1016/j.orcp.2014.05.002
   Konopka AR, 2014, EXERC SPORT SCI REV, V42, P53, DOI 10.1249/JES.0000000000000007
   Kontulainen SA, 2002, INT J SPORTS MED, V23, P575, DOI 10.1055/s-2002-35543
   Kraemer William J, 1989, Pediatr Exerc Sci, V1, P336, DOI 10.1123/pes.1.4.336
   KRISTINSSON JO, 1994, J INTERN MED, V236, P385, DOI 10.1111/j.1365-2796.1994.tb00814.x
   Kubo K, 2010, J APPL BIOMECH, V26, P316, DOI 10.1123/jab.26.3.316
   Kubo K, 2010, J STRENGTH COND RES, V24, P322, DOI 10.1519/JSC.0b013e3181c865e2
   Larsen LR, 2015, MED SCI SPORT EXER, V47, P1849, DOI 10.1249/MSS.0000000000000604
   Larsen MN, 2018, BRIT J SPORT MED, V52, P254, DOI 10.1136/bjsports-2016-096219
   Lauersen JB, 2014, BRIT J SPORT MED, V48, DOI 10.1136/bjsports-2013-092538
   Leahy AA, 2020, MED SCI SPORT EXER, V52, P2224, DOI 10.1249/MSS.0000000000002359
   Lee S., 2019, J Pediatr, V206
   Lee S, 2019, J OBES METAB SYNDR, V28, P76, DOI 10.7570/jomes.2019.28.2.76
   Lee S, 2013, AM J PHYSIOL-ENDOC M, V305, pE1222, DOI 10.1152/ajpendo.00285.2013
   Lee S, 2012, DIABETES, V61, P2787, DOI 10.2337/db12-0214
   Legerlotz K, 2016, PEDIATR EXERC SCI, V28, P501, DOI 10.1123/pes.2016-0023
   Lelieveld OTHM, 2008, ARTHRIT RHEUM-ARTHR, V59, P1379, DOI 10.1002/art.24102
   Lesinski M, 2020, SPORTS MED, V50, P1901, DOI 10.1007/s40279-020-01327-3
   Lesinski M, 2016, BRIT J SPORT MED, V50, P781, DOI 10.1136/bjsports-2015-095497
   Li CY, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-31190-x
   Li Z, 2024, SCAND J MED SCI SPOR, V34, DOI 10.1111/sms.14764
   Lillegard W A, 1997, Pediatr Rehabil, V1, P147
   Llanos-Lagos C, 2024, SPORTS MED, V54, P1801, DOI 10.1007/s40279-024-02018-z
   Llanos-Lagos C, 2024, SPORTS MED, V54, P895, DOI 10.1007/s40279-023-01978-y
   Lloyd RS, 2015, J STRENGTH COND RES, V29, P1439, DOI 10.1519/JSC.0000000000000756
   Lloyd RS, 2014, BRIT J SPORT MED, V48, P498, DOI 10.1136/bjsports-2013-092952
   Lloyd RS, 2012, STRENGTH COND J, V34, P61, DOI 10.1519/SSC.0b013e31825760ea
   Lubans DR, 2010, SPORTS MED, V40, P1019, DOI 10.2165/11536850-000000000-00000
   MacKelvie KJ, 2002, J BONE MINER RES, V17, P834, DOI 10.1359/jbmr.2002.17.5.834
   Maher CA, 2007, DEV MED CHILD NEUROL, V49, P450, DOI 10.1111/j.1469-8749.2007.00450.x
   Malina R.M., 2004, GROWTH MATURATION PH
   Malina RM, 2006, CLIN J SPORT MED, V16, P478, DOI 10.1097/01.jsm.0000248843.31874.be
   Mandorino M, 2023, BIOL SPORT, V40, P27, DOI 10.5114/biolsport.2023.109962
   Markovic G, 2010, SPORTS MED, V40, P859, DOI 10.2165/11318370-000000000-00000
   Marson EC, 2016, PREV MED, V93, P211, DOI 10.1016/j.ypmed.2016.10.020
   Marta C, 2013, INT J SPORTS MED, V34, P888, DOI 10.1055/s-0033-1333695
   Martínez-Gómez D, 2011, SCAND J MED SCI SPOR, V21, P310, DOI 10.1111/j.1600-0838.2009.01036.x
   McCormack SE, 2017, JAMA PEDIATR, V171, DOI 10.1001/jamapediatrics.2017.1769
   McLeod TCV, 2011, J ATHL TRAINING, V46, P206, DOI 10.4085/1062-6050-46.2.206
   McQuilliam SJ, 2020, SPORTS MED, V50, P1567, DOI 10.1007/s40279-020-01307-7
   Min Seok-Ki, 2019, J Bone Metab, V26, P225, DOI 10.11005/jbm.2019.26.4.225
   Moran J, 2018, SPORTS MED, V48, P1661, DOI 10.1007/s40279-018-0914-4
   Moran J, 2018, J STRENGTH COND RES, V32, P139, DOI 10.1519/JSC.0000000000001780
   Moran J, 2017, J SPORT SCI, V35, P1041, DOI 10.1080/02640414.2016.1209306
   Myer GD, 2011, CURR SPORT MED REP, V10, P157, DOI 10.1249/JSR.0b013e31821b1442
   Myer GD, 2011, PHYSICIAN SPORTSMED, V39, P74, DOI 10.3810/psm.2011.02.1854
   Myer GD, 2009, J STRENGTH COND RES, V23, P2054, DOI 10.1519/JSC.0b013e3181b86712
   Negra Y, 2020, INT J SPORT PHYSIOL, V15, P189, DOI 10.1123/ijspp.2018-0866
   Negra Y, 2020, J SPORT HEALTH SCI, V9, P620, DOI 10.1016/j.jshs.2016.07.008
   Negra Y, 2016, J STRENGTH COND RES, V30, P3290, DOI 10.1519/JSC.0000000000001433
   Nguyen Vu H, 2018, Osteoporos Sarcopenia, V4, P39, DOI 10.1016/j.afos.2018.05.002
   Orsso CE, 2019, CLIN NUTR, V38, P2002, DOI 10.1016/j.clnu.2019.04.012
   Ortega FB, 2008, INT J OBESITY, V32, P1, DOI 10.1038/sj.ijo.0803774
   Ortega FB, 2012, BMJ-BRIT MED J, V345, DOI 10.1136/bmj.e7279
   OZMUN JC, 1994, MED SCI SPORT EXER, V26, P510
   Paavolainen L, 1999, J APPL PHYSIOL, V86, P1527
   Parrish AM, 2020, INT J BEHAV NUTR PHY, V17, DOI [10.1186/s12966-020-00993-w, 10.1186/s12966-020-0914-2]
   Paulozzi Leonard, 2012, Morbidity and Mortality Weekly Report, V61, P10
   Pereira S, 2022, MED SCI SPORT EXER, V54, P2129, DOI 10.1249/MSS.0000000000003013
   Peterson MD, 2016, AM J PREV MED, V50, P593, DOI 10.1016/j.amepre.2015.09.019
   Peterson MD, 2014, PEDIATRICS, V133, pE896, DOI 10.1542/peds.2013-3169
   Phillips SM, 2023, ACSMS HEALTH FIT J, V27, P19, DOI 10.1249/FIT.0000000000000916
   Piercy KL, 2018, CIRC-CARDIOVASC QUAL, V11, DOI 10.1161/CIRCOUTCOMES.118.005263
   Pillsbury L., 2013, Fitness measures and health outcomes in youth
   Proia P, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.704647
   Ramirez-Campillo R, 2020, J STRENGTH COND RES, V34, P1959, DOI 10.1519/JSC.0000000000002525
   RAMSAY JA, 1990, MED SCI SPORT EXER, V22, P605, DOI 10.1249/00005768-199010000-00011
   Ribeiro-Dos-Santos Marcelo R, 2016, J Bone Metab, V23, P149, DOI 10.11005/jbm.2016.23.3.149
   Rizzoli R, 2010, BONE, V46, P294, DOI 10.1016/j.bone.2009.10.005
   Robinson K, 2023, SPORTS MED, V53, P2095, DOI 10.1007/s40279-023-01881-6
   Valero FJR, 2015, NUTR HOSP, V32, P1560, DOI 10.3305/nh.2015.32.4.9310
   Rössler R, 2014, SPORTS MED, V44, P1733, DOI 10.1007/s40279-014-0234-2
   Ruiz JR, 2009, BRIT J SPORT MED, V43, P909, DOI 10.1136/bjsm.2008.056499
   Sadres E, 2001, PEDIATR EXERC SCI, V13, P357, DOI 10.1123/pes.13.4.357
   Saint-Maurice PF, 2018, ARCH OSTEOPOROS, V13, DOI 10.1007/s11657-018-0502-0
   Sammoud S, 2024, BMC SPORTS SCI MED R, V16, DOI 10.1186/s13102-024-00821-9
   Sammoud S, 2022, J SPORT SCI, V40, P130, DOI 10.1080/02640414.2021.1976570
   Sammoud S, 2019, J SPORT SCI MED, V18, P805
   Sandercock GRH, 2019, J SCI MED SPORT, V22, P201, DOI 10.1016/j.jsams.2018.07.020
   Schranz N, 2014, BRIT J SPORT MED, V48, P1482, DOI 10.1136/bjsports-2013-092209
   Schranz N, 2013, SPORTS MED, V43, P893, DOI 10.1007/s40279-013-0062-9
   Shigaki GB., 2019, J Hum Growth Dev, V29, P381, DOI [10.7322/jhgd.v29.9537, DOI 10.7322/JHGD.V29.9537]
   Sigal RJ, 2014, JAMA PEDIATR, V168, P1006, DOI 10.1001/jamapediatrics.2014.1392
   Sioen I, 2016, CALCIFIED TISSUE INT, V99, P557, DOI 10.1007/s00223-016-0183-x
   Small EW, 2008, PEDIATRICS, V121, P835, DOI 10.1542/peds.2007-3790
   Smith JJ, 2019, SPORTS MED, V49, P887, DOI 10.1007/s40279-019-01089-7
   Smith JJ, 2014, SPORTS MED, V44, P1209, DOI 10.1007/s40279-014-0196-4
   Steene-Johannessen J, 2009, MED SCI SPORT EXER, V41, P1361, DOI 10.1249/MSS.0b013e31819aaae5
   Steib S, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00920
   Stovitz SD, 2019, Distinguishing between causal and non-causal associations: implications for sports medicine clinicians, P398
   Stratton G, 2004, J SPORT SCI, V22, P383, DOI 10.1080/02640410310001641629
   Stricker PR, 2020, PEDIATRICS, V145, DOI 10.1542/peds.2020-1011
   Suchomel TJ, 2018, SPORTS MED, V48, P765, DOI 10.1007/s40279-018-0862-z
   Sugimoto D, 2015, BRIT J SPORT MED, V49, P282, DOI 10.1136/bjsports-2014-093461
   Telama R, 2005, AM J PREV MED, V28, P267, DOI 10.1016/j.amepre.2004.12.003
   Telama R, 2014, MED SCI SPORT EXER, V46, P955, DOI 10.1249/MSS.0000000000000181
   Telama R, 2009, OBESITY FACTS, V2, P187, DOI 10.1159/000222244
   Thompson AM, 2003, QUAL HEALTH RES, V13, P358, DOI 10.1177/1049732302250332
   Tian X, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18189648
   Timpka S, 2014, BMC MED, V12, DOI 10.1186/1741-7015-12-62
   Toien T, 2023, J APPL PHYSIOL, V135, P1360, DOI 10.1152/japplphysiol.00208.2023
   Tomkinson GR, 2021, SPORTS MED, V51, P531, DOI 10.1007/s40279-020-01394-6
   Tomkinson GR, 2018, BRIT J SPORT MED, V52, P1445, DOI 10.1136/bjsports-2017-098253
   Tomporowski PD, 2019, PSYCHOL BULL, V145, P929, DOI 10.1037/bul0000200
   Martín LT, 2023, RES SPORTS MED, V31, P574, DOI 10.1080/15438627.2021.2010205
   TSUJI S, 1995, ARCH PHYS MED REHAB, V76, P234, DOI 10.1016/S0003-9993(95)80607-5
   Tyler J, 2023, Int J Strength Cond., V3
   U.S. Department of Health and Human Services, 2018, 2018 Physical activity guidelines advisory committee scientific report
   Van Every DW, 2024, EXERC SPORT SCI REV, V52, P117, DOI 10.1249/JES.0000000000000346
   Vicente-Rodríguez G, 2006, SPORTS MED, V36, P561, DOI 10.2165/00007256-200636070-00002
   Vingren JL, 2010, SPORTS MED, V40, P1037, DOI 10.2165/11536910-000000000-00000
   Vlachopoulos D, 2018, A 9-month jumping intervention to improve bone geometry in adolescent male athletes
   VRIJENS J., 1978, MED SPORT, V11, P152
   Walters BK, 2018, J SPORT MED PHYS FIT, V58, P1339, DOI 10.23736/S0022-4707.17.07409-6
   Weeks BK, 2008, J BONE MINER RES, V23, P1002, DOI 10.1359/JBMR.080226
   Witzke KA, 2000, MED SCI SPORT EXER, V32, P1051, DOI 10.1097/00005768-200006000-00003
   Wong PL, 2010, J STRENGTH COND RES, V24, P644, DOI 10.1519/JSC.0b013e3181ad3349
   Wrotniak BH, 2006, PEDIATRICS, V118, pE1758, DOI 10.1542/peds.2006-0742
   Zwolski C, 2017, SPORTS HEALTH, V9, P436, DOI 10.1177/1941738117704153
NR 233
TC 0
Z9 0
U1 2
U2 2
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 0112-1642
EI 1179-2035
J9 SPORTS MED
JI Sports Med.
PD 2025 MAY 26
PY 2025
DI 10.1007/s40279-025-02240-3
EA MAY 2025
PG 18
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA 2ZF7A
UT WOS:001494837800001
PM 40418528
DA 2025-06-11
ER

PT J
AU Eriksson, MD
   Eriksson, JG
   Korhonen, P
   Koponen, H
   Salonen, MK
   Mikkola, TM
   Kajantie, E
   Wasenius, NS
   von Bonsdorff, M
   Kautiainen, H
   Laine, MK
AF Eriksson, Mia D.
   Eriksson, Johan G.
   Korhonen, Paivi
   Koponen, Hannu
   Salonen, Minna K.
   Mikkola, Tuija M.
   Kajantie, Eero
   Wasenius, Niko S.
   von Bonsdorff, Mikaela
   Kautiainen, Hannu
   Laine, Merja K.
TI Depressive symptoms and mortality-findings from Helsinki birth cohort
   study
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE cohort studies; comorbidity; depression; depressive disorder; mortality
ID ALL-CAUSE MORTALITY; METABOLIC SYNDROME; EXCESS MORTALITY; RISK-FACTOR;
   INTERVENTION; METAANALYSIS; ASSOCIATION; INVENTORY; DISEASE; HEALTH
AB Background Individuals with depression and depressive symptoms have a higher mortality rate than non-depressed individuals. The increased comorbidity and mortality associated with depression has remained largely unexplained. The underlying pathophysiological differences between depressive subtypes, melancholic and non-melancholic, may provide some explanation to this phenomenon. Methods One thousand nine hundred and ninety five participants (mean age 61 years) from the Helsinki Birth Cohort Study were recruited for this prospective study and followed up for a mean of 14.1 years. Information regarding medical history, lifestyle, and biochemical parameters were obtained. Depressive symptoms were assessed using the Beck Depression Inventory. Standardized mortality ratios were calculated. Results Participants were followed up for a total of 28,044 person-years. The melancholic depressive group had an increased adjusted risk of mortality [HR 1.49 (95% CI: 1.02-2.20)] when compared to the non-depressive group. Comparing mortality to the whole population of Finland using standardized mortality ratios (SMR) both the non-melancholic [1.11 (95% CI: 0.85-1.44)] and melancholic depressive [1.26 (95% CI: 0.87-1.81)] groups had higher mortality than the non-depressive group [0.82 (95% CI: 0.73-0.93)]. Conclusions Melancholic depressive symptoms are most strongly related to a higher mortality risk.
C1 [Eriksson, Mia D.; Eriksson, Johan G.; Wasenius, Niko S.; Laine, Merja K.] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.
   [Eriksson, Mia D.; Eriksson, Johan G.; Koponen, Hannu; Wasenius, Niko S.; Laine, Merja K.] Helsinki Univ Hosp, Helsinki, Finland.
   [Eriksson, Mia D.; Eriksson, Johan G.; Salonen, Minna K.; Mikkola, Tuija M.; Wasenius, Niko S.; von Bonsdorff, Mikaela; Kautiainen, Hannu; Laine, Merja K.] Folkhalsan Res Ctr, Helsinki, Finland.
   [Eriksson, Mia D.] Univ Helsinki, Fac Med, Doctoral Programme Populat Hlth, Helsinki, Finland.
   [Eriksson, Johan G.] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Obstet & Gynecol, Singapore, Singapore.
   [Eriksson, Johan G.] Natl Univ Singapore, Yong Loo Lin Sch Med, Human Potential Translat Res Programme, Singapore, Singapore.
   [Eriksson, Johan G.] ASTAR, Singapore Inst Clin Sci SICS, Singapore, Singapore.
   [Korhonen, Paivi] Turku Univ Hosp, Turku, Finland.
   [Korhonen, Paivi] Univ Turku, Turku, Finland.
   [Koponen, Hannu] Univ Helsinki, Dept Psychiat, Helsinki, Finland.
   [Salonen, Minna K.; Kajantie, Eero] Finnish Inst Hlth & Welf, Dept Publ Hlth Solut, Publ Hlth Promot Unit, Helsinki, Finland.
   [Mikkola, Tuija M.] Univ Helsinki, Fac Med, Clinicum, Helsinki, Finland.
   [Kajantie, Eero] Oulu Univ Hosp, PEDEGO Res Unit, MRC Oulu, Oulu, Finland.
   [Kajantie, Eero] Univ Oulu, Oulu, Finland.
   [Kajantie, Eero] Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway.
   [von Bonsdorff, Mikaela] Univ Jyvaskyla, Gerontol Res Ctr, Jyvaskyla, Finland.
   [von Bonsdorff, Mikaela] Univ Jyvaskyla, Fac Sport & Hlth Sci, Jyvaskyla, Finland.
   [Kautiainen, Hannu] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
C3 University of Helsinki; University of Helsinki; Helsinki University
   Central Hospital; Folkhalsan Research Center; University of Helsinki;
   National University of Singapore; National University of Singapore;
   Agency for Science Technology & Research (A*STAR); A*STAR - Singapore
   Institute for Clinical Sciences (SICS); University of Turku; University
   of Turku; University of Helsinki; University of Helsinki; University of
   Oulu; University of Oulu; Norwegian University of Science & Technology
   (NTNU); University of Jyvaskyla; University of Jyvaskyla; University of
   Eastern Finland
RP Eriksson, MD (corresponding author), Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.; Eriksson, MD (corresponding author), Helsinki Univ Hosp, Helsinki, Finland.
EM mia.eriksson@helsinki.fi
RI Gibbs, J. Raphael/A-3984-2010; Wasenius, Niko/AAE-8927-2020; von
   Bonsdorff, Mikaela/A-5218-2015; /H-8100-2016; Mikkola, Tuija/L-2835-2014
OI Eriksson, Johan/0000-0002-2516-2060; von Bonsdorff,
   Mikaela/0000-0001-8530-5230; Koponen, Hannu/0000-0002-7368-1869;
   /0000-0002-1848-1514; Mikkola, Tuija/0000-0003-0885-2788; Eriksson,
   Mia/0000-0001-8968-8304; Wasenius, Niko/0000-0002-9007-6660
FU Academy of Finland; EU; European Commission; Finnish Special
   Governmental Subsidy for Health Sciences; Finska Lakaresallskapet;
   Foundation for Cardiovascular Research; Foundation for Diabetes
   Research; Foundation for Pediatric Research; Horizon2020; Medicinska
   Understodsforeningen Liv och Halsa; Novo Nordisk Foundation; Samfundet
   Folkhalsan; Signe ja Ane Gyllenbergin Saatio
FX Academy of Finland; EU; European Commission; Finnish Special
   Governmental Subsidy for Health Sciences; Finska Lakaresallskapet;
   Foundation for Cardiovascular Research; Foundation for Diabetes
   Research; Foundation for Pediatric Research; Horizon2020; Medicinska
   Understodsforeningen Liv och Halsa; Novo Nordisk Foundation; Samfundet
   Folkhalsan; Signe ja Ane Gyllenbergin Saatio
CR Ainsworth BE, 2011, MED SCI SPORT EXER, V43, P1575, DOI 10.1249/MSS.0b013e31821ece12
   Akil H, 2018, NEUROSCI BIOBEHAV R, V84, P272, DOI 10.1016/j.neubiorev.2017.08.019
   [Anonymous], 2017, World Health Organization Report
   Barker DJP, 2005, NEW ENGL J MED, V353, P1802, DOI 10.1056/NEJMoa044160
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   BECK AT, 1988, CLIN PSYCHOL REV, V8, P77, DOI 10.1016/0272-7358(88)90050-5
   Christensen GT, 2017, J AFFECT DISORDERS, V210, P111, DOI 10.1016/j.jad.2016.12.024
   Cuijpers P, 2014, AM J PSYCHIAT, V171, P453, DOI 10.1176/appi.ajp.2013.13030325
   Cuijpers P, 2013, BRIT J PSYCHIAT, V202, P22, DOI 10.1192/bjp.bp.112.112169
   Eriksson JG, 2016, ANN MED, V48, P456, DOI 10.1080/07853890.2016.1193786
   FOSSATI P, 1982, CLIN CHEM, V28, P2077
   Gallo JJ, 2007, ANN INTERN MED, V146, P689, DOI 10.7326/0003-4819-146-10-200705150-00002
   Gallo JJ, 2016, J GEN INTERN MED, V31, P380, DOI 10.1007/s11606-015-3524-y
   Gawlik-Kotelnicka O, 2021, LIFE-BASEL, V11, DOI 10.3390/life11020117
   Gilman SE, 2017, CAN MED ASSOC J, V189, pE1304, DOI 10.1503/cmaj.170125
   Gump BB, 2005, STROKE, V36, P98, DOI 10.1161/01.STR.0000149626.50127.d0
   Harrell FE, 2015, SPRINGER SER STAT, P1, DOI 10.1007/978-3-319-19425-7_1
   Harris EC, 1998, BRIT J PSYCHIAT, V173, P11, DOI 10.1192/bjp.173.1.11
   LAKKA TA, 1992, INT J EPIDEMIOL, V21, P467, DOI 10.1093/ije/21.3.467
   Lamers F, 2013, MOL PSYCHIATR, V18, P692, DOI 10.1038/mp.2012.144
   Lasserre AM, 2016, J AFFECT DISORDERS, V189, P17, DOI 10.1016/j.jad.2015.09.010
   LIE RF, 1976, CLIN CHEM, V22, P1627
   Malhi GS, 2018, LANCET, V392, P2299, DOI 10.1016/S0140-6736(18)31948-2
   Markkula Niina, 2017, Duodecim, V133, P275
   Penninx BWJH, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-129
   Pulska T, 2001, MORTALITY DEPRESSED
   Rantanen AT, 2020, J PSYCHOSOM RES, V133, DOI 10.1016/j.jpsychores.2020.110107
   Saint Onge JM, 2014, J GERONTOL B-PSYCHOL, V69, P622, DOI 10.1093/geronb/gbu009
   Schulz R, 2002, BIOL PSYCHIAT, V52, P205, DOI 10.1016/S0006-3223(02)01423-3
   Seppala J., 2010, PSYCHIAT FENNICA, V41, P42
   Seppälä J, 2012, J AFFECT DISORDERS, V138, P473, DOI 10.1016/j.jad.2012.01.007
   Seppälä J, 2012, J AFFECT DISORDERS, V136, P543, DOI 10.1016/j.jad.2011.10.032
   Sullivan MD, 2012, DIABETES CARE, V35, P1708, DOI 10.2337/dc11-1791
   Tamada Y, 2021, NEUROPSYCH DIS TREAT, V17, P1105, DOI 10.2147/NDT.S300233
   Vanhala M, 2009, ACTA PSYCHIAT SCAND, V119, P137, DOI 10.1111/j.1600-0447.2008.01283.x
   WHO, 2004, Global Burden of Disease 2004 Update: Disability Weights for Diseases and Conditions (WHO)
   World Health Organization, 2017, Global Hepatitis Report 2017
   Wu YT, 2020, INT J GERIATR PSYCH, V35, P29, DOI 10.1002/gps.5211
NR 38
TC 8
Z9 8
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
EI 1600-0447
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD FEB
PY 2023
VL 147
IS 2
BP 175
EP 185
DI 10.1111/acps.13512
EA NOV 2022
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 8D1PF
UT WOS:000877733700001
PM 36263580
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Chantler, PD
   Frisbee, JC
AF Chantler, Paul D.
   Frisbee, Jefferson C.
TI Arterial Function in Cardio-Metabolic Diseases: From the
   Microcirculation to the Large Conduits
SO PROGRESS IN CARDIOVASCULAR DISEASES
LA English
DT Review
DE Vascular disease; Metabolic syndrome; Obesity; Insulin resistance; Blood
   flow
ID TYPE-2 DIABETES-MELLITUS; INTIMA-MEDIA THICKNESS; INSULIN-RESISTANCE;
   RISK-FACTORS; MICROVASCULAR RAREFACTION; ENDOTHELIAL DYSFUNCTION;
   CARDIOVASCULAR EVENTS; INFLAMMATORY MARKERS; VASCULAR REACTIVITY;
   ANGIOTENSIN-II
AB The metabolic syndrome (MetS) is characterized as a constellation of metabolic risk factors such as obesity, hypertension, dyslipidemia, and hyperglycemia that co-occur within a given individual. This consultation of risk factors exposes MetS to a 3-fold increased risk of cardiovascular disease and an even higher risk of developing type 2 diabetes compared to healthy individuals. The pathophysiological mechanisms underlying this increased cardiovascular risk are incompletely understood but likely include alterations to macro- and micro-vasculature. The vasculature plays an important role not only in delivery and adjusting the quantity of blood delivered to the tissues, but the dynamic changes in structure and compliance significantly alter the hemodynamic stress imposed on the heart and end-organs. This review will give an overview of the pathophysiological changes to the vasculature that accompany MetS in both human and animal models, as well as the possible mechanistic pathways. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Chantler, Paul D.] W Virginia Univ, Sch Med, Div Exercise Physiol, Morgantown, WV 26505 USA.
   [Chantler, Paul D.; Frisbee, Jefferson C.] W Virginia Univ, Sch Med, Ctr Cardiovasc & Resp Sci, Morgantown, WV 26505 USA.
   [Frisbee, Jefferson C.] W Virginia Univ, Sch Med, Dept Physiol & Pharmacol, Morgantown, WV 26505 USA.
C3 West Virginia University; West Virginia University; West Virginia
   University
RP Frisbee, JC (corresponding author), W Virginia Univ, POB 9229, Morgantown, WV 26505 USA.
EM jefrisbee@hsc.wvu.edu
OI Frisbee, Jefferson/0000-0003-2751-0599
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Aronson D, 2003, J HYPERTENS, V21, P3, DOI 10.1097/00004872-200301000-00002
   Bahia Luciana, 2006, Clinics, V61, P433, DOI 10.1590/S1807-59322006000500010
   Bai Y, 2009, AM J NEPHROL, V29, P213, DOI 10.1159/000156715
   Bakker ENTP, 2006, CIRC RES, V99, P86, DOI 10.1161/01.RES.0000229657.83816.a7
   Benedict KF, 2011, MICROCIRCULATION, V18, P63, DOI 10.1111/j.1549-8719.2010.00069.x
   Benjamin EJ, 2004, CIRCULATION, V109, P613, DOI 10.1161/01.CIR.0000112565.60887.1E
   Blanco-Colio LM, 2007, AM HEART J, V153, P881, DOI 10.1016/j.ahj.2007.02.029
   Booth AD, 2004, ARTHRITIS RHEUM, V50, P581, DOI 10.1002/art.20002
   Bouvet C, 2008, ARTERIOSCL THROM VAS, V28, P856, DOI 10.1161/ATVBAHA.107.153056
   Brohall G, 2006, DIABETIC MED, V23, P609, DOI 10.1111/j.1464-5491.2005.01725.x
   Brook RD, 2001, AM J CARDIOL, V88, P1264, DOI 10.1016/S0002-9149(01)02088-4
   BROWNLEE M, 1988, NEW ENGL J MED, V318, P1315
   Cardillo C, 2002, CIRCULATION, V106, P1783, DOI 10.1161/01.CIR.0000032260.01569.64
   Chander PN, 2004, J AM SOC NEPHROL, V15, P2391, DOI 10.1097/01.ASN.0000135971.88164.2C
   Cortez-Cooper MY, 2005, AM J HYPERTENS, V18, P930, DOI 10.1016/j.amjhyper.2005.01.008
   Czernichow S, 2010, HYPERTENS RES, V33, P293, DOI 10.1038/hr.2009.228
   de Jongh RT, 2004, DIABETES, V53, P2873, DOI 10.2337/diabetes.53.11.2873
   de Lemos ET, 2009, NUTRITION, V25, P330, DOI 10.1016/j.nut.2008.08.014
   de Moraes Camila, 2008, BMC Physiology, V8, P12, DOI 10.1186/1472-6793-8-12
   Demircan N, 2008, MED SCI MONITOR, V14, pCR97
   Donley DA, 2014, J APPL PHYSIOL, V116, P1396, DOI 10.1152/japplphysiol.00151.2014
   Emilsson V, 2008, NATURE, V452, P423, DOI 10.1038/nature06758
   Eskurza I, 2004, J PHYSIOL-LONDON, V556, P315, DOI 10.1113/jphysiol.2003.057042
   Esposito K, 2006, DIABETES CARE, V29, P1071, DOI 10.2337/dc05-2174
   Ferreira I, 2012, HYPERTENSION, V60, P542, DOI 10.1161/HYPERTENSIONAHA.112.194738
   Ferri C, 1997, EXP CLIN ENDOCR DIAB, V105, P38, DOI 10.1055/s-0029-1211794
   Fichtlscherer S, 2000, CIRCULATION, V102, P1000, DOI 10.1161/01.CIR.102.9.1000
   Ford ES, 2003, ATHEROSCLEROSIS, V168, P351, DOI 10.1016/S0021-9150(03)00134-5
   Fournier SB, 2014, EXP PHYSIOL, V99, P149, DOI 10.1113/expphysiol.2013.075796
   Francischetti EA, 2011, MICROVASC RES, V81, P325, DOI 10.1016/j.mvr.2011.01.002
   Frisbee JC, 2005, MICROCIRCULATION, V12, P383, DOI 10.1080/10739680590960241
   Frisbee JC, 2005, AM J PHYSIOL-REG I, V289, pR307, DOI 10.1152/ajpregu.00114.2005
   Frisbee JC, 2006, AM J PHYSIOL-HEART C, V291, pH2483, DOI 10.1152/ajpheart.00566.2006
   Fujimoto N, 2013, CIRC-HEART FAIL, V6, P1155, DOI 10.1161/CIRCHEARTFAILURE.113.000440
   GLAGOV S, 1992, J HYPERTENS, V10, pS101
   Goldin A, 2006, CIRCULATION, V114, P597, DOI 10.1161/CIRCULATIONAHA.106.621854
   Goodwill AG, 2012, VASC PHARMACOL, V57, P150, DOI 10.1016/j.vph.2012.07.002
   Grassi G, 2010, J HYPERTENS, V28, P1708, DOI 10.1097/HJH.0b013e32833af3c9
   Grundy SM, 2006, CURR OPIN CARDIOL, V21, P1, DOI 10.1097/01.hco.0000200416.65370.a0
   Hamburg NM, 2008, AM J CARDIOL, V101, P82, DOI 10.1016/j.amjcard.2007.07.053
   Hanon O, 2005, STROKE, V36, P2193, DOI 10.1161/01.STR.0000181771.82518.1c
   Henry RMA, 2004, STROKE, V35, P671, DOI 10.1161/01.STR.0000115752.58601.0B
   Hermans MMH, 2007, J AM SOC NEPHROL, V18, P1942, DOI 10.1681/ASN.2006111217
   Hill BJF, 2001, ATHEROSCLEROSIS, V159, P117, DOI 10.1016/S0021-9150(01)00501-9
   HOTAMISLIGIL GS, 1994, P NATL ACAD SCI USA, V91, P4854, DOI 10.1073/pnas.91.11.4854
   Itani SI, 2002, DIABETES, V51, P2005, DOI 10.2337/diabetes.51.7.2005
   Kangas P, 2013, METABOLISM, V62, P1114, DOI 10.1016/j.metabol.2013.02.009
   KOHN RR, 1984, DIABETES, V33, P57, DOI 10.2337/diabetes.33.1.57
   Kuvin JT, 2003, AM J CARDIOL, V92, P275, DOI 10.1016/S0002-9149(03)00623-4
   Levy BI, 2001, CIRCULATION, V104, P735, DOI 10.1161/hc3101.091158
   Li J, 2012, MAYO CLIN PROC, V87, P968, DOI 10.1016/j.mayocp.2012.07.004
   Limberg JK, 2013, AM J PHYSIOL-HEART C, V305, pH1230, DOI 10.1152/ajpheart.00291.2013
   Lind L, 2008, ATHEROSCLEROSIS, V196, P795, DOI 10.1016/j.atherosclerosis.2007.01.014
   Lorenz MW, 2007, CIRCULATION, V115, P459, DOI 10.1161/CIRCULATIONAHA.106.628875
   Lupattelli G, 2000, AM HEART J, V140, P521, DOI 10.1067/mhj.2000.108508
   Madden KM, 2009, DIABETES CARE, V32, P1531, DOI 10.2337/dc09-0149
   Marchesi C, 2009, HYPERTENSION, V54, P1384, DOI 10.1161/HYPERTENSIONAHA.109.138305
   Mathieu-Costello O, 2003, METABOLISM, V52, P540, DOI 10.1053/meta.2002.50108
   Miyachi M, 2004, CIRCULATION, V110, P2858, DOI 10.1161/01.CIR.0000146380.08401.99
   Pietri P, 2006, J HYPERTENS, V24, P2231, DOI 10.1097/01.hjh.0000249701.49854.21
   Protogerou AD, 2007, ATHEROSCLEROSIS, V193, P151, DOI 10.1016/j.atherosclerosis.2006.05.046
   Recio-Mayoral A, 2013, JACC-CARDIOVASC IMAG, V6, P660, DOI 10.1016/j.jcmg.2012.12.011
   Reddy GK, 2004, MICROVASC RES, V68, P132, DOI 10.1016/j.mvr.2004.04.002
   Ritchie SA, 2004, CLIN SCI, V107, P519, DOI 10.1042/CS20040190
   Romero MJ, 2012, AM J PHYSIOL-HEART C, V302, pH159, DOI 10.1152/ajpheart.00774.2011
   Safar ME, 2006, J AM COLL CARDIOL, V47, P72, DOI 10.1016/j.jacc.2005.08.052
   Schofield I, 2002, CIRCULATION, V106, P3037, DOI 10.1161/01.CIR.0000041432.80615.A5
   Schreihofer AM, 2005, AM J PHYSIOL-REG I, V288, pR253, DOI 10.1152/ajpregu.00498.2004
   Scuteri A, 2004, J AM COLL CARDIOL, V43, P1388, DOI 10.1016/j.jacc.2003.10.061
   Scuteri A, 2014, ATHEROSCLEROSIS, V233, P654, DOI 10.1016/j.atherosclerosis.2014.01.041
   Scuteri A, 2010, EUR HEART J, V31, P602, DOI 10.1093/eurheartj/ehp491
   Shatanawi A, 2011, AM J PHYSIOL-CELL PH, V300, pC1181, DOI 10.1152/ajpcell.00328.2010
   Sonoyama Kazuhiko, 2007, Ther Adv Cardiovasc Dis, V1, P129, DOI 10.1177/1753944707086358
   Souza-Smith FM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023337
   Stapleton PA, 2007, AM J PHYSIOL-REG I, V293, pR1110, DOI 10.1152/ajpregu.00410.2007
   Stensvold D, 2010, J APPL PHYSIOL, V108, P804, DOI 10.1152/japplphysiol.00996.2009
   Stepp DW, 2004, AM J PHYSIOL-HEART C, V286, pH964, DOI 10.1152/ajpheart.00836.2003
   Targonski PV, 2003, CIRCULATION, V107, P2805, DOI 10.1161/01.CIR.0000072765.93106.EE
   Tedesco MA, 2004, J HUM HYPERTENS, V18, P469, DOI 10.1038/sj.jhh.1001690
   Trask AJ, 2012, J APPL PHYSIOL, V113, P1128, DOI 10.1152/japplphysiol.00604.2012
   Tripathy D, 2003, DIABETES, V52, P2882, DOI 10.2337/diabetes.52.12.2882
   Vlachopoulos C, 2010, J AM COLL CARDIOL, V55, P1318, DOI 10.1016/j.jacc.2009.10.061
   Weisbrod RM, 2013, HYPERTENSION, V62, P1105, DOI 10.1161/HYPERTENSIONAHA.113.01744
   Wilkinson IB, 2004, HYPERTENSION, V44, P112, DOI 10.1161/01.HYP.0000138068.03893.40
   Williams B, 2001, AM J CARDIOL, V87, p10C
   Yoshizawa M, 2009, BRIT J SPORT MED, V43, P615, DOI 10.1136/bjsm.2008.052126
NR 87
TC 18
Z9 27
U1 0
U2 9
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0033-0620
EI 1873-1740
J9 PROG CARDIOVASC DIS
JI Prog. Cardiovasc. Dis.
PD MAR-APR
PY 2015
VL 57
IS 5
BP 489
EP 496
DI 10.1016/j.pcad.2014.09.005
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CE4NP
UT WOS:000351807600010
PM 25220256
DA 2025-06-11
ER

PT J
AU Sironi, AM
   Sicari, R
   Folli, F
   Gastaldelli, A
AF Sironi, Anna Maria
   Sicari, Rosa
   Folli, Franco
   Gastaldelli, Amalia
TI Ectopic Fat Storage, Insulin Resistance, and Hypertension
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Visceral fat; epicardial fat; hepatic fat; perivascular fat; pancreatic
   fat; metabolic syndrome; blood pressure
ID RENIN-ANGIOTENSIN SYSTEM; SYSTOLIC BLOOD-PRESSURE; BODY-MASS-INDEX;
   ADIPOSE-TISSUE; VISCERAL FAT; ARTERIAL-HYPERTENSION; ACUTE
   HYPERGLYCEMIA; ALDOSTERONE LEVELS; GENE-EXPRESSION; WEIGHT-LOSS
AB Obesity, insulin resistance, glucose intolerance/type 2 diabetes and hypertension are clustered in the metabolic syndrome representing critical risk factors for increased incidence cardio-cerebro-vascular diseases, kidney failure and cancer. Ectopic fat accumulation, i.e., accumulation in the mediastinum, liver and the abdomen, as well as generalized fat accumulation are associated with arterial hypertension, either systolic or diastolic. Several mechanisms including insulin resistance, sub-inflammatory state, increased Renin-Angiotensin-Aldosterone System (RAAS) system activity, oxidative stress, autonomic dysregulation as well as mechanical compression on the kidneys are all activated by obesity. Interestingly angiotensin-converting enzyme (ACE) inhibitors and angiotensin II (ATII) receptor blockers, while correcting arterial hypertension, also have a positive effect on glucose metabolism and diabetes prevention, in high risk patients. The implementation of dietary, medical and surgical strategies to prevent and treat obesity, are cornerstones for the primary prevention as well as treatment of arterial hypertension.
C1 [Sironi, Anna Maria; Sicari, Rosa; Gastaldelli, Amalia] CNR, Inst Clin Physiol, Pisa, Italy.
   [Folli, Franco; Gastaldelli, Amalia] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto di Fisiologia Clinica
   (IFC-CNR); University of Texas System; University of Texas Health
   Science Center at San Antonio
RP Gastaldelli, A (corresponding author), CNR, Inst Clin Physiol, Pisa, Italy.
EM amalia.gastaldelli@ifc.cnr.it
RI folli, franco/J-2795-2018; Gastaldelli, Amalia/H-3319-2014
OI folli, franco/0000-0001-9824-5222; Gastaldelli,
   Amalia/0000-0003-2594-1651
FU Consiglio Nazionale delle Ricerche(CNR); European Foundation for the
   Study of Diabetes (EFSD)
FX This work was supported by funds of the Consiglio Nazionale delle
   Ricerche(CNR) and by a grant of the European Foundation for the Study of
   Diabetes (EFSD).
CR Alpert A, 1998, HEART LUNG OBESITY
   Andreozzi F, 2004, CIRC RES, V94, P1211, DOI 10.1161/01.RES.0000126501.34994.96
   Aneja A, 2004, RECENT PROG HORM RES, V59, P169, DOI 10.1210/rp.59.1.169
   [Anonymous], 1986, Prev Med, V15, P254
   Aronne LJ, 1997, OBES RES, V5, P354, DOI 10.1002/j.1550-8528.1997.tb00564.x
   Atzmon G, 2002, HORM METAB RES, V34, P622, DOI 10.1055/s-2002-38250
   Baynes JW, 2000, FREE RADICAL BIO MED, V28, P1708, DOI 10.1016/S0891-5849(00)00228-8
   Beckman JA, 2001, CIRCULATION, V103, P1618, DOI 10.1161/01.CIR.103.12.1618
   Benetos A, 2000, J AM COLL CARDIOL, V35, P673, DOI 10.1016/S0735-1097(99)00586-0
   BJORNTORP P, 1990, CLIN EXP HYPERTENS A, V12, P783, DOI 10.3109/10641969009073499
   Buchwald H, 2004, JAMA-J AM MED ASSOC, V292, P1724, DOI 10.1001/jama.292.14.1724
   Ceriello A, 1997, DIABETIC MED, V14, pS45, DOI 10.1002/(SICI)1096-9136(199708)14:3+<S45::AID-DIA444>3.3.CO;2-I
   Chagnac A, 2008, NEPHROL DIAL TRANSPL, V23, P3946, DOI 10.1093/ndt/gfn379
   Chang CJ, 2010, AM J MED, V123, P432, DOI 10.1016/j.amjmed.2009.07.031
   CROFT JB, 1993, INT J OBESITY, V17, P391
   Dall'Asta C, 2009, NUTR METAB CARDIOVAS, V19, P110, DOI 10.1016/j.numecd.2008.06.001
   Despres JP., 1998, OBES RES, V6, p8S
   Doll S, 2002, INT J OBESITY, V26, P48, DOI 10.1038/sj.ijo.0801854
   Dyer AR, 1999, J HUM HYPERTENS, V13, P13, DOI 10.1038/sj.jhh.1000740
   Egan BM, 2010, JAMA-J AM MED ASSOC, V303, P2043, DOI 10.1001/jama.2010.650
   Engeli S, 2000, HYPERTENSION, V35, P1270, DOI 10.1161/01.HYP.35.6.1270
   Faria AN, 2002, OBES RES, V10, P1203, DOI 10.1038/oby.2002.164
   FERRANNINI E, 1987, NEW ENGL J MED, V317, P350, DOI 10.1056/NEJM198708063170605
   Folli F, 1997, J CLIN INVEST, V100, P2158, DOI 10.1172/JCI119752
   Fox CS, 2007, CIRCULATION, V116, P39, DOI 10.1161/CIRCULATIONAHA.106.675355
   Franklin SS, 1999, J HYPERTENS, V17, pS29
   GARRISON RJ, 1987, PREV MED, V16, P235, DOI 10.1016/0091-7435(87)90087-9
   Gastaldelli A, 2010, NUTR METAB CARDIOVAS, V20, P481, DOI 10.1016/j.numecd.2010.05.005
   Gastaldelli A, 2007, GASTROENTEROLOGY, V133, P496, DOI 10.1053/j.gastro.2007.04.068
   Gastaldelli A, 2009, HEPATOLOGY, V49, P1537, DOI 10.1002/hep.22845
   Goodfriend TL, 1999, OBES RES, V7, P355, DOI 10.1002/j.1550-8528.1999.tb00418.x
   GREKIN RJ, 1995, HYPERTENSION, V26, P193, DOI 10.1161/01.HYP.26.1.193
   Guagnano MT, 2001, INT J OBESITY, V25, P1360, DOI 10.1038/sj.ijo.0801722
   Guzik TJ, 2007, J PHYSIOL PHARMACOL, V58, P591
   Harte A, 2005, CIRCULATION, V111, P1954, DOI 10.1161/01.CIR.0000161954.17870.5D
   Heni M, 2010, DIABETES-METAB RES, V26, P200, DOI 10.1002/dmrr.1073
   Hershon KS, 2011, ENDOCR PRACT, P10
   Jensen MD, 2003, AM J PHYSIOL-ENDOC M, V285, pE1282, DOI 10.1152/ajpendo.00220.2003
   JONES DW, 1994, J HYPERTENS, V12, P1433, DOI 10.1097/00004872-199412000-00018
   Lee Y, 2010, INT J OBESITY, V34, P396, DOI 10.1038/ijo.2009.245
   Licht CMM, 2010, J CLIN ENDOCR METAB, V95, P2458, DOI 10.1210/jc.2009-2801
   Mancia G, 2005, HYPERTENSION, V45, P1072, DOI 10.1161/01.HYP.0000165672.69176.ed
   Mancia G, 2007, J HYPERTENS, V25, P1751, DOI 10.1097/HJH.0b013e3282f0580f
   Masuo K, 2000, HYPERTENSION, V35, P1135, DOI 10.1161/01.HYP.35.5.1135
   Mathieu P, 2009, HYPERTENSION, V53, P577, DOI 10.1161/HYPERTENSIONAHA.108.110320
   McMurray JJ, 2010, NEW ENGL J MED, V362, P1477, DOI 10.1056/NEJMoa1001121
   MESSERLI FH, 1981, ARCH INTERN MED, V141, P81, DOI 10.1001/archinte.141.1.81
   Miyazaki Y, 2002, DIABETES CARE, V25, P517, DOI 10.2337/diacare.25.3.517
   Muscelli E, 1998, J CLIN ENDOCR METAB, V83, P2084, DOI 10.1210/jc.83.6.2084
   Muscogiuri G, 2008, CURR VASC PHARMACOL, V6, P301, DOI 10.2174/157016108785909715
   Neter JE, 2003, HYPERTENSION, V42, P878, DOI 10.1161/01.HYP.0000094221.86888.AE
   Nishina M, 2003, HYPERTENS RES, V26, P281, DOI 10.1291/hypres.26.281
   Perseghin G, 2008, HEPATOLOGY, V47, P51, DOI 10.1002/hep.21983
   Pontiroli AE, 2005, DIABETES CARE, V28, P2703, DOI 10.2337/diacare.28.11.2703
   Porter LE, 1998, HYPERTENSION, V32, P144, DOI 10.1161/01.HYP.32.1.144
   Rahmouni K, 2004, AM J PHYSIOL-ENDOC M, V286, pE891, DOI 10.1152/ajpendo.00551.2003
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Saad MF, 2004, HYPERTENSION, V43, P1324, DOI 10.1161/01.HYP.0000128019.19363.f9
   Sacks HS, 2007, AM HEART J, V153, P907, DOI 10.1016/j.ahj.2007.03.019
   Sacks HS, 2011, DIABETES CARE, V34, P730, DOI 10.2337/dc10-2083
   Scheen AJ, 2004, DRUGS, V64, P2537, DOI 10.2165/00003495-200464220-00004
   Sironi AM, 2004, HYPERTENSION, V44, P127, DOI 10.1161/01.HYP.0000137982.10191.0a
   Sironi AM, 2008, HYPERTENSION, V51, P282, DOI 10.1161/HYPERTENSIONAHA.107.098640
   Sjöström L, 2007, NEW ENGL J MED, V357, P741, DOI 10.1056/NEJMoa066254
   Sorof J, 2002, HYPERTENSION, V40, P441, DOI 10.1161/01.HYP.0000032940.33466.12
   SPIEGELMAN D, 1992, AM J CLIN NUTR, V55, P1033, DOI 10.1093/ajcn/55.6.1033
   Staessen JA, 2000, LANCET, V355, P865, DOI 10.1016/S0140-6736(99)07330-4
   Strazzullo P, 2001, J HYPERTENS, V19, P399, DOI 10.1097/00004872-200103000-00007
   TANAKA S, 1990, DIABETES RES CLIN PR, V10, pS199, DOI 10.1016/0168-8227(90)90164-O
   Targher G, 2010, NEW ENGL J MED, V363, P1341, DOI 10.1056/NEJMra0912063
   Unger RH, 2003, ANNU REV PHYSIOL, V65, P333, DOI 10.1146/annurev.physiol.65.092101.142622
   Valera-Mora ME, 2005, AM J CLIN NUTR, V81, P1292
   Vanni E, 2010, DIGEST LIVER DIS, V42, P320, DOI 10.1016/j.dld.2010.01.016
   Velloso LA, 1996, P NATL ACAD SCI USA, V93, P12490, DOI 10.1073/pnas.93.22.12490
   Villanova N, 2005, HEPATOLOGY, V42, P473, DOI 10.1002/hep.20781
   Visser FW, 2009, OBESITY, V17, P1684, DOI 10.1038/oby.2009.61
   Yudkin JS, 2005, LANCET, V365, P1817, DOI 10.1016/S0140-6736(05)66585-3
   Yvan-Charvet L, 2011, KIDNEY INT, V79, P162, DOI 10.1038/ki.2010.391
NR 79
TC 20
Z9 25
U1 2
U2 13
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD SEP
PY 2011
VL 17
IS 28
BP 3074
EP 3080
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 883KP
UT WOS:000299633200011
PM 21861830
DA 2025-06-11
ER

PT J
AU Prachayasittikul, V
   Prachayasittikul, S
   Ruchirawat, S
   Prachayasittikul, V
AF Prachayasittikul, Veda
   Prachayasittikul, Supaluk
   Ruchirawat, Somsak
   Prachayasittikul, Virapong
TI Coriander (Coriandrum sativum): A promising functional food
   toward the well-being
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Review
DE Coriandrum sativum; Functional food; Linalool; Antioxidant;
   Neuroprotective; Metabolic syndrome
ID ESSENTIAL OIL COMPOSITION; L. ESSENTIAL OIL; PENTYLENETETRAZOLE-INDUCED
   SEIZURES; FATTY-ACID-COMPOSITION; IN-VITRO; ANTIOXIDANT ACTIVITY;
   SPILANTHES-ACMELLA; OXIDATIVE STRESS; BLOOD-PRESSURE; ASCORBIC-ACID
AB Coriandrum sativum (C. sativum) or coriander is one of the most popularly used spices in culinary worldwide, and its medicinal values has been recognized since ancient time. C. sativum contains bioactive phytochemicals that are accounted for a wide range of biological activities including antioxidant, anticancer, neuroprotective, anxiolytic, anticonvulsant, analgesic, migraine-relieving, hypolipidemic, hypoglycemic, hypotensive, antimicrobial, and antiinflammatory activities. The major compound, linalool, abundantly found in seeds is remarked for its abilities to modulate many key pathogenesis pathways of diseases. Apart from the modulating effects, the potent antioxidant property of the C. sativum provides a key mechanism behind its protective effects against neurodegenerative diseases, cancer, and metabolic syndrome. This review shed light on comprehensive aspects regarding the therapeutic values of the C. sativum, which indicate its significance of being a promising functional food for promoting the well-being in the era of aging and lifestyle-related diseases.
C1 [Prachayasittikul, Veda; Prachayasittikul, Supaluk] Mahidol Univ, Fac Med Technol, Ctr Data Min & Biomed Informat, Bangkok 10700, Thailand.
   [Ruchirawat, Somsak] Chulabhorn Res Inst, Lab Med Chem, Bangkok 10210, Thailand.
   [Ruchirawat, Somsak] Chulabhorn Grad Inst, Program Chem Biol, Bangkok 10210, Thailand.
   [Ruchirawat, Somsak] Minist Educ, Commiss Higher Educ, Ctr Excellence Environm Hlth & Toxicol, Bangkok, Thailand.
   [Prachayasittikul, Virapong] Mahidol Univ, Fac Med Technol, Dept Clin Microbiol & Appl Technol, Bangkok 10700, Thailand.
C3 Mahidol University; Chulabhorn Research Institute; Chulabhorn Graduate
   Institute; Mahidol University
RP Prachayasittikul, V (corresponding author), Mahidol Univ, Fac Med Technol, Ctr Data Min & Biomed Informat, Bangkok 10700, Thailand.
EM veda.pra@mahidol.ac.th
RI Prachayasittikul, Veda/J-2384-2019; Prachayasittikul,
   Supaluk/AAO-5375-2020
OI Prachayasittikul, Virapong/0000-0001-7942-1083; Prachayasittikul,
   Veda/0000-0001-6338-3721
CR Adams M, 2012, J ETHNOPHARMACOL, V143, P1, DOI 10.1016/j.jep.2012.06.010
   Adewale OO, 2015, PHYTOTHER RES, V29, P978, DOI 10.1002/ptr.5353
   Adhikari A., 2008, International Journal of Cosmetic Science, V30, P353, DOI 10.1111/j.1468-2494.2008.00463.x
   Ahmad SS, 2016, CNS NEUROL DISORD-DR, V15, P1279, DOI 10.2174/1871527315666161003165855
   Ailinger Rita L, 2004, J Transcult Nurs, V15, P278, DOI 10.1177/1043659604268936
   Aissaoui A, 2008, J ETHNOPHARMACOL, V115, P89, DOI 10.1016/j.jep.2007.09.007
   Aissaoui A, 2011, J ETHNOPHARMACOL, V137, P652, DOI 10.1016/j.jep.2011.06.019
   Akerman S, 2017, PHARMACOL THERAPEUT, V172, P151, DOI 10.1016/j.pharmthera.2016.12.005
   Anaeigoudari A, 2016, AVICENNA J PHYTOMEDI, V6, P223
   Anfenan M. L. K., 2014, World Applied Sciences Journal, V30, P1504
   Anjos PJC, 2013, Z NATURFORSCH C, V68, P181
   [Anonymous], J ALZHEIMERS DIS
   [Anonymous], APPL BIOCH BIOTECHNO
   [Anonymous], INT J GREEN PHARM
   [Anonymous], 2012, J MED PLANT
   [Anonymous], J HERBAL MED TOXICOL
   [Anonymous], FOOD COSMETICS TOXIC
   [Anonymous], 2014, J FOOD SCI TECH MYS, DOI DOI 10.1007/s13197-012-0648-5
   [Anonymous], 2012, International Journal of Pharmacological Science
   [Anonymous], 2014, Int. J. Pharm. Pharm. Sci
   [Anonymous], AM J PHARMTECH RES
   [Anonymous], 2012, ADV BIOSCI BIOTECHNO
   [Anonymous], CEPHALALGIA
   Anum EA, 2004, ANN EPIDEMIOL, V14, P705, DOI 10.1016/j.annepidem.2003.10.009
   Anwar F, 2011, J MED PLANTS RES, V5, P3537
   Barros L, 2012, FOOD CHEM, V132, P841, DOI 10.1016/j.foodchem.2011.11.048
   Batista PA, 2008, NEUROSCI LETT, V440, P299, DOI 10.1016/j.neulet.2008.05.092
   Batista PA, 2010, J PAIN, V11, P1222, DOI 10.1016/j.jpain.2010.02.022
   Bazargani MM, 2016, FOOD CONTROL, V61, P156, DOI 10.1016/j.foodcont.2015.09.036
   Behrendt HJ, 2004, BRIT J PHARMACOL, V141, P737, DOI 10.1038/sj.bjp.0705652
   Beirith A, 2002, BRAIN RES, V924, P219, DOI 10.1016/S0006-8993(01)03240-1
   Benyoussef E, 2013, FLAVOUR FRAG J, V28, P300, DOI 10.1002/ffj.3169
   Bhat S. P., 2014, The Journal of Phytopharmacology, V3, P254, DOI [10.31254/phyto.2014.3406, DOI 10.31254/PHYTO.2014.3406]
   Bhuiyan M. N. I., 2009, Bangladesh Journal of Pharmacology, V4, P150, DOI 10.3329/bjp.v4i2.2800
   Birch AM, 2014, J NEUROINFLAMM, V11, DOI 10.1186/1742-2094-11-25
   Bopanna K. N., 1997, Indian Journal of Pharmacology, V29, P162
   Bouic PJD, 1996, INT J IMMUNOPHARMACO, V18, P693, DOI 10.1016/S0192-0561(97)85551-8
   Brum LFS, 2001, NEUROCHEM RES, V26, P191, DOI 10.1023/A:1010904214482
   Burdock GA, 2009, FOOD CHEM TOXICOL, V47, P22, DOI 10.1016/j.fct.2008.11.006
   Buzzi FD, 2009, EUR J MED CHEM, V44, P4596, DOI 10.1016/j.ejmech.2009.06.029
   Cairns RA, 2011, NAT REV CANCER, V11, P85, DOI 10.1038/nrc2981
   Caraci F, 2010, EUR J PHARMACOL, V626, P64, DOI 10.1016/j.ejphar.2009.10.022
   Carlton SM, 1999, BRAIN RES, V820, P63, DOI 10.1016/S0006-8993(98)01328-6
   Cha J, 2013, INT J ONCOL, V42, P55, DOI 10.3892/ijo.2012.1712
   Chasman DI, 2014, PLOS GENET, V10, DOI 10.1371/journal.pgen.1004366
   Chatterjee S, 2012, AM J PHYSIOL-HEART C, V302, pH105, DOI 10.1152/ajpheart.00298.2011
   Chaudhry Nazia Masood Ahmed, 2006, Pak J Pharm Sci, V19, P214
   Chen Q, 2005, P NATL ACAD SCI USA, V102, P13604, DOI 10.1073/pnas.0506390102
   Chen YC, 2001, J CELL BIOCHEM, V82, P537, DOI 10.1002/jcb.1184
   Chen YH, 2012, INT J ENV RES PUB HE, V9, P4150, DOI 10.3390/ijerph9114150
   Cheng Bing-Ho, 2015, J Tradit Complement Med, V5, P27, DOI 10.1016/j.jtcme.2014.10.007
   Chiang LC, 2003, AM J CHINESE MED, V31, P37, DOI 10.1142/S0192415X03000825
   CHILDERS SR, 1991, LIFE SCI, V48, P1991, DOI 10.1016/0024-3205(91)90154-4
   Chithra V, 1999, FOOD CHEM, V67, P229, DOI 10.1016/S0308-8146(99)00113-2
   Chithra V, 2000, J ETHNOPHARMACOL, V71, P457, DOI 10.1016/S0378-8741(00)00182-3
   Chithra V, 1999, INDIAN J BIOCHEM BIO, V36, P59
   Chithra V, 1997, PLANT FOOD HUM NUTR, V51, P167, DOI 10.1023/A:1007975430328
   Chizh BA, 2001, NEUROPHARMACOLOGY, V40, P212, DOI 10.1016/S0028-3908(00)00148-9
   Cho KJ, 2000, TOXICOL APPL PHARM, V166, P120, DOI 10.1006/taap.2000.8958
   Cho SY, 2011, FEBS LETT, V585, P3289, DOI 10.1016/j.febslet.2011.09.012
   Cioanca O, 2014, PHYSIOL BEHAV, V131, P68, DOI 10.1016/j.physbeh.2014.04.021
   Cioanca O, 2013, PHYSIOL BEHAV, V120, P193, DOI 10.1016/j.physbeh.2013.08.006
   Colaianna M, 2010, BRIT J PHARMACOL, V159, P1704, DOI 10.1111/j.1476-5381.2010.00669.x
   Craig D, 2005, AM J GERIAT PSYCHIAT, V13, P460, DOI 10.1176/appi.ajgp.13.6.460
   Daly T, 2010, PLANT FOOD HUM NUTR, V65, P164, DOI 10.1007/s11130-010-0167-3
   Daniel MJ, 2011, AM HEALTH DRUG BENEF, V4, P312
   Day TW, 2008, BIOCHEM PHARMACOL, V76, P1694, DOI 10.1016/j.bcp.2008.09.007
   de Figueiredo RO, 2004, ACTA HORTIC, P135, DOI 10.17660/ActaHortic.2004.629.18
   de Sousa DP, 2010, NAT PROD COMMUN, V5, P1847
   Deepa Balasubramaniam, 2011, Diabetologia Croatica, V40, P121
   Delaquis PJ, 2002, INT J FOOD MICROBIOL, V74, P101, DOI 10.1016/S0168-1605(01)00734-6
   Dhanapakiam P, 2008, J ENVIRON BIOL, V29, P53
   Di Pasqua R, 2006, J AGR FOOD CHEM, V54, P2745, DOI 10.1021/jf052722l
   Dias MI, 2011, PLANT FOOD HUM NUTR, V66, P181, DOI 10.1007/s11130-011-0227-3
   Doyle KP, 2008, NEUROPHARMACOLOGY, V55, P310, DOI 10.1016/j.neuropharm.2008.01.005
   Draelos ZD, 2013, J COSMET DERMATOL-US, V12, P1, DOI 10.1111/jocd.12028
   Duke JA., 2002, Handbook of medicinal herbs
   Dussor G, 2016, HEADACHE, V56, P1406, DOI 10.1111/head.12948
   Eidi M, 2009, PHYTOTHER RES, V23, P404, DOI 10.1002/ptr.2642
   ELISABETSKY E, 1995, NEUROCHEM RES, V20, P461, DOI 10.1007/BF00973103
   Elisabetsky E, 1999, PHYTOMEDICINE, V6, P107, DOI 10.1016/S0944-7113(99)80044-0
   Emamghoreishi M, 2005, J ETHNOPHARMACOL, V96, P365, DOI 10.1016/j.jep.2004.06.022
   Emamghoreishi M., 2010, IRAN J PHARM RES, P71
   Ertas O. N., 2013, International Journal of Poultry Science, V12, P436
   Esserlind AL, 2013, EUR J NEUROL, V20, P765, DOI 10.1111/ene.12055
   Evens AM, 2005, BLOOD, V105, P1265, DOI 10.1182/blood-2004-03-0964
   Fahmy H. A., 2014, European Journal of Medicinal Plants, V4, P196
   Fajemiroye JO, 2016, FUND CLIN PHARMACOL, V30, P198, DOI 10.1111/fcp.12186
   Findeis MA, 2007, PHARMACOL THERAPEUT, V116, P266, DOI 10.1016/j.pharmthera.2007.06.006
   Firuzi O, 2011, CURR MED CHEM, V18, P3871, DOI 10.2174/092986711803414368
   Fournier N, 1999, ATHEROSCLEROSIS, V147, P227, DOI 10.1016/S0021-9150(99)00188-4
   Franco OH, 2005, HYPERTENSION, V46, P280, DOI 10.1161/01.HYP.0000173433.67426.9b
   Freires ID, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0099086
   Gallagher AM, 2003, NUTR RES, V23, P413, DOI 10.1016/S0271-5317(02)00533-X
   Giles Thomas D, 2005, J Clin Hypertens (Greenwich), V7, P505, DOI 10.1111/j.1524-6175.2005.04769.x
   GODFRAIND T, 1986, PHARMACOL REV, V38, P321
   Goh SY, 2008, J CLIN ENDOCR METAB, V93, P1143, DOI 10.1210/jc.2007-1817
   Golden SH, 2002, DIABETES, V51, P3069, DOI 10.2337/diabetes.51.10.3069
   Golechha M, 2010, INDIAN J EXP BIOL, V48, P474
   Gottesman RF, 2014, JAMA NEUROL, V71, P1218, DOI 10.1001/jamaneurol.2014.1646
   Gradinariu V, 2015, PHYTOCHEM REV, V14, P567, DOI 10.1007/s11101-014-9389-6
   Griebel G, 1999, NEUROPHARMACOLOGY, V38, P965, DOI 10.1016/S0028-3908(99)00026-X
   Grieve M., 1971, A Modern Herbal
   Gu Y, 2010, TOXICOLOGY, V268, P19, DOI 10.1016/j.tox.2009.11.013
   Guerra NB, 2005, J FOOD COMPOS ANAL, V18, P193, DOI 10.1016/j.jfca.2003.12.006
   Gupta S, 2001, BIOCHEM BIOPH RES CO, V287, P914, DOI 10.1006/bbrc.2001.5672
   Hansen MB, 2003, PHYSIOL RES, V52, P1, DOI 10.33549/physiolres.930255
   Hayashi Y, 2012, NEUROSCI LETT, V531, P166, DOI 10.1016/j.neulet.2012.10.044
   Higashima M, 2002, BRAIN RES, V949, P157, DOI 10.1016/S0006-8993(02)02976-1
   Hosseinzadeh Samaneh, 2016, J Parasit Dis, V40, P1307, DOI 10.1007/s12639-015-0676-y
   Hu J, 2002, J AGR FOOD CHEM, V50, P2587, DOI 10.1021/jf0114740
   Hwang E, 2014, J MED FOOD, V17, P985, DOI 10.1089/jmf.2013.2999
   Ibn-e-Sina AH, 2005, Al-qanun fit-tib the canon of medicine, P41
   Ishikawa T, 2003, CHEM PHARM BULL, V51, P32, DOI 10.1248/cpb.51.32
   Jabeen Q, 2009, J ETHNOPHARMACOL, V122, P123, DOI 10.1016/j.jep.2008.12.016
   JACKSON DL, 1995, EUR J PHARMACOL, V284, P321, DOI 10.1016/0014-2999(95)00449-U
   Jaisin Y, 2016, SCIENCEASIA, V42, P259, DOI 10.2306/scienceasia1513-1874.2016.42.259
   Jana S, 2014, NUTR CANCER, V66, P835, DOI 10.1080/01635581.2014.904906
   Jenner P., 1964, Food Cosmet Toxicol, V2, P327
   Jesse CR, 2008, PROG NEURO-PSYCHOPH, V32, P1838, DOI 10.1016/j.pnpbp.2008.08.010
   Jia Q, 2009, PHYTOMEDICINE, V16, P744, DOI 10.1016/j.phymed.2008.12.012
   Jo Y, 2010, CRIT REV BIOCHEM MOL, V45, P185, DOI 10.3109/10409238.2010.485605
   Juárez-Rojop IE, 2014, REV BRAS FARMACOGN, V24, P341, DOI 10.1016/j.bjp.2014.07.012
   Jun HJ, 2014, J LIPID RES, V55, P1098, DOI 10.1194/jlr.M045807
   Kandlakunta B, 2008, FOOD CHEM, V106, P85, DOI 10.1016/j.foodchem.2007.05.071
   Kang P, 2015, J PHARM PHARMACOL, V67, P714, DOI 10.1111/jphp.12359
   Kang P, 2013, J PHARM PHARMACOL, V65, P745, DOI 10.1111/jphp.12031
   Kansal L, 2011, INT J APPL BIOL PHAR, V2, P65, DOI DOI 10.13040/IJPSR.0975-8232.4(7).2789-93
   Karami R, 2015, IRAN J NEUROL, V14, P59
   Kasmaei HD, 2016, IRAN RED CRESCENT ME, V18, DOI 10.5812/ircmj.20759
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kaur R, 2005, J MED FOOD, V8, P529, DOI 10.1089/jmf.2005.8.529
   Kazemi S.M., 2015, Iranian Journal of Animal Biosystematics, V11, P23
   Khan SW, 2008, PAK J BOT, V40, P43
   Kim HG, 2007, J ETHNOPHARMACOL, V114, P307, DOI 10.1016/j.jep.2007.08.011
   Kitajima J, 2003, PHYTOCHEMISTRY, V62, P115, DOI 10.1016/S0031-9422(02)00438-7
   Kondeti VK, 2010, FOOD CHEM TOXICOL, V48, P1281, DOI 10.1016/j.fct.2010.02.023
   Kubo I, 2004, J AGR FOOD CHEM, V52, P3329, DOI 10.1021/jf0354186
   Kurbacher CM, 1996, CANCER LETT, V103, P183, DOI 10.1016/0304-3835(96)04212-7
   Lakhera Abhijeet, 2015, Interdiscip Toxicol, V8, P99, DOI 10.1515/intox-2015-0015
   Lal A. Arun Sam, 2004, Indian Journal of Experimental Biology, V42, P909
   Lanfer-Marquez UM, 2005, FOOD RES INT, V38, P885, DOI 10.1016/j.foodres.2005.02.012
   Laribi B, 2015, FITOTERAPIA, V103, P9, DOI 10.1016/j.fitote.2015.03.012
   Lawrence B. M., 1993, New crops. Proceedings of the Second National Symposium: New crops, exploration, research and commercialization, Indianapolis, Indiana, October 6-9, 1991., P620
   Lee JC, 2003, EXP CELL RES, V291, P386, DOI 10.1016/S0014-4827(03)00410-5
   Lee S, 2007, J FOOD SCI, V72, pS497, DOI 10.1111/j.1750-3841.2007.00446.x
   Lee SC, 2013, J AGR FOOD CHEM, V61, P4905, DOI 10.1021/jf401039z
   Lev E, 2008, J ETHNOPHARMACOL, V119, P24, DOI 10.1016/j.jep.2008.05.042
   Linck VM, 2010, PHYTOMEDICINE, V17, P679, DOI 10.1016/j.phymed.2009.10.002
   Linck VD, 2009, PHYTOMEDICINE, V16, P303, DOI 10.1016/j.phymed.2008.08.001
   Loizzo MR, 2008, CELL PROLIFERAT, V41, P1002, DOI 10.1111/j.1365-2184.2008.00561.x
   Lujan-Barroso L, 2014, CANCER CAUSE CONTROL, V25, P639, DOI 10.1007/s10552-014-0359-5
   Mandal Shyamapada, 2015, Asian Pacific Journal of Tropical Biomedicine, V5, P421, DOI 10.1016/j.apjtb.2015.04.001
   Marangoni C, 2011, CIENCIA TECNOL ALIME, V31, P124, DOI 10.1590/S0101-20612011000100017
   Marc EB, 2008, J ETHNOPHARMACOL, V120, P315, DOI 10.1016/j.jep.2008.08.024
   Sabogal-Guáqueta AM, 2016, NEUROPHARMACOLOGY, V102, P111, DOI 10.1016/j.neuropharm.2015.11.002
   Maroufi K., 2010, Advances in Environmental Biology, V4, P433
   Martins N, 2016, IND CROP PROD, V79, P188, DOI 10.1016/j.indcrop.2015.11.018
   Matés JM, 2000, INT J BIOCHEM CELL B, V32, P157, DOI 10.1016/S1357-2725(99)00088-6
   Mathew M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0086804
   Matkowski A, 2008, BIOTECHNOL ADV, V26, P548, DOI 10.1016/j.biotechadv.2008.07.001
   McGuffin M., 1997, Botanical safety handbook
   McKemy DD, 2002, NATURE, V416, P52, DOI 10.1038/nature719
   Mehri S, 2015, DRUG CHEM TOXICOL, V38, P162, DOI 10.3109/01480545.2014.919585
   Mehrotra A, 2011, EUR J PHARMACOL, V666, P80, DOI 10.1016/j.ejphar.2011.05.039
   Melo ED, 2003, EUR J LIPID SCI TECH, V105, P483, DOI 10.1002/ejlt.200300811
   Meyer L, 2013, BEHAV BRAIN RES, V253, P90, DOI 10.1016/j.bbr.2013.07.010
   Millar JS, 2013, CURR OPIN LIPIDOL, V24, P233, DOI 10.1097/MOL.0b013e3283613a7d
   Miller M, 2011, CIRCULATION, V123, P2292, DOI 10.1161/CIR.0b013e3182160726
   Miura T, 2001, J NUTR SCI VITAMINOL, V47, P340, DOI 10.3177/jnsv.47.340
   Mojska H, 2012, FOOD CHEM TOXICOL, V50, P2722, DOI 10.1016/j.fct.2012.05.023
   Mojska H, 2010, FOOD CHEM TOXICOL, V48, P2090, DOI 10.1016/j.fct.2010.05.009
   Moneret-Vautrin D A, 2002, Allerg Immunol (Paris), V34, P135
   Msaada K, 2007, FOOD CHEM, V102, P1131, DOI 10.1016/j.foodchem.2006.06.046
   Msaada K, 2017, ARAB J CHEM, V10, pS3176, DOI 10.1016/j.arabjc.2013.12.011
   Msaada K, 2009, J FOOD BIOCHEM, V33, P603, DOI 10.1111/j.1745-4514.2009.00240.x
   Msaada K, 2009, SCI HORTIC-AMSTERDAM, V122, P116, DOI 10.1016/j.scienta.2009.04.008
   Msaada K, 2009, SCI HORTIC-AMSTERDAM, V120, P525, DOI 10.1016/j.scienta.2008.11.033
   Mukherjee P. K., 2001, Journal of Natural Remedies, V1, P125
   Mussarat S., 2014, EVID BASED COMPLEMEN, V2014, DOI [10.1155/2014/212634, DOI 10.1155/2014/212634]
   Nair Vinod, 2013, J Ayurveda Integr Med, V4, P13, DOI 10.4103/0975-9476.109544
   Nair V, 2012, INDIAN J MED RES, V135, P240
   Nanditha BR, 2009, J SCI FOOD AGR, V89, P288, DOI 10.1002/jsfa.3440
   Narkhede M.B., 2012, Asian J. Pharm. Clin. Res., V5, P75
   Neffati M, 2008, IND CROP PROD, V28, P137, DOI 10.1016/j.indcrop.2008.02.005
   NEHER E, 1978, J PHYSIOL-LONDON, V277, P153, DOI 10.1113/jphysiol.1978.sp012267
   NELSON MT, 1995, AM J PHYSIOL-CELL PH, V268, pC799, DOI 10.1152/ajpcell.1995.268.4.C799
   NIINIMAKI A, 1981, ALLERGY, V36, P487, DOI 10.1111/j.1398-9995.1981.tb01860.x
   NIINIMAKI A, 1995, ANN ALLERG ASTHMA IM, V75, P280
   O'Sullivan GJ, 2008, NEUROPHARMACOLOGY, V54, P1051, DOI 10.1016/j.neuropharm.2008.02.011
   Ochiai T, 2004, NEUROSCI LETT, V362, P61, DOI 10.1016/j.neulet.2004.02.067
   Oganesyan E.T., 2007, PHARM CHEM J+, V41, P149, DOI [10.1007/s11094-007-0033-2, DOI 10.1007/S11094-007-0033-2]
   Osmak M, 1997, NEOPLASMA, V44, P101
   Padalia K, 2015, AFR J TRADIT COMPLEM, V12, P100, DOI 10.4314/ajtcam.v12i6.10
   Paik SY, 2005, BIOL PHARM BULL, V28, P802, DOI 10.1248/bpb.28.802
   Paladini AC, 1999, J PHARM PHARMACOL, V51, P519, DOI 10.1211/0022357991772790
   Pari L, 2003, PHARMAZIE, V58, P916
   Park G, 2012, SKIN PHARMACOL PHYS, V25, P93, DOI 10.1159/000335257
   Peana AT, 2006, LIFE SCI, V78, P2471, DOI 10.1016/j.lfs.2005.10.025
   Peana AT, 2004, EUR J PHARMACOL, V497, P279, DOI 10.1016/j.ejphar.2004.06.006
   Peier AM, 2002, CELL, V108, P705, DOI 10.1016/S0092-8674(02)00652-9
   Peng XL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0079476
   Perera HKI, 2015, BMC COMPLEM ALTERN M, V15, DOI 10.1186/s12906-015-0689-1
   Petersen KF, 2006, AM J MED, V119, p10S, DOI 10.1016/j.amjmed.2006.01.009
   Pi XJ, 2004, MOL BRAIN RES, V127, P60, DOI 10.1016/j.molbrainres.2004.05.006
   Pieroni A, 2008, PHYTOTHER RES, V22, P889, DOI 10.1002/ptr.2410
   Pino J. A., 1996, Journal of Essential Oil Research, V8, P97
   Platel K, 2004, INDIAN J MED RES, V119, P167
   Prachayasittikul S., 2010, EUR J SCI RES, V44, P167
   Prachayasittikul S, 2009, MOLECULES, V14, P850, DOI 10.3390/molecules14020850
   Prachayasittikul V, 2013, EXCLI J, V12, P291
   Putchala MC, 2013, ARCH ORAL BIOL, V58, P563, DOI 10.1016/j.archoralbio.2013.01.016
   Puthusseri B, 2013, FOOD CHEM, V136, P569, DOI 10.1016/j.foodchem.2012.09.005
   Puthusseri B, 2012, PLANT FOOD HUM NUTR, V67, P162, DOI 10.1007/s11130-012-0285-1
   Raal A., 2004, Agraarteadus, V15, P234
   Raju J, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0073916
   Rakhshandeh H, 2012, NAT PROD RES, V26, P2095, DOI 10.1080/14786419.2011.613388
   Ramadan MF, 2003, J AGR FOOD CHEM, V51, P6961, DOI 10.1021/jf0346713
   Ramadan MF, 2002, EUR FOOD RES TECHNOL, V215, P204, DOI 10.1007/s00217-002-0537-7
   Ramadan MF, 2008, EUR FOOD RES TECHNOL, V227, P1173, DOI 10.1007/s00217-008-0833-y
   Rattanachaikunsopon P, 2010, BIOSCI BIOTECH BIOCH, V74, P31, DOI 10.1271/bbb.90409
   Ravi R, 2007, EUR FOOD RES TECHNOL, V225, P367, DOI 10.1007/s00217-006-0425-7
   Ravizza R, 2008, ONCOL REP, V20, P625, DOI 10.3892/or_00000051
   Re L, 2000, PHARMACOL RES, V42, P177, DOI 10.1006/phrs.2000.0671
   Reddy V, 2005, FOOD CHEM, V90, P317, DOI 10.1016/j.foodchem.2004.05.038
   Reilly C, 2011, SEIZURE-EUR J EPILEP, V20, P589, DOI 10.1016/j.seizure.2011.06.004
   Rodgers RJ, 1997, NEUROSCI BIOBEHAV R, V21, P801, DOI 10.1016/S0149-7634(96)00058-9
   Rodrigo R, 2012, ADV CLIN CHEM, V58, P225, DOI 10.1016/B978-0-12-394383-5.00014-X
   Rodrigues AD, 2012, NEUROCHEM INT, V60, P799, DOI 10.1016/j.neuint.2012.01.009
   RYLSKI M, 1979, Acta Physiologica Polonica, V30, P385
   Sadeghian A, 2011, AVICENNA J PHYTOMEDI, V1, P67
   Sakurada T, 2011, PHARMACOL BIOCHEM BE, V97, P436, DOI 10.1016/j.pbb.2010.09.020
   Samojlik I, 2010, J AGR FOOD CHEM, V58, P8848, DOI 10.1021/jf101645n
   Sampaio LDS, 2012, PHYTOTHER RES, V26, P73, DOI 10.1002/ptr.3518
   Santos ARS, 1999, EUR J PHARMACOL, V379, P7, DOI 10.1016/S0014-2999(99)00490-2
   Schieber M, 2014, CURR BIOL, V24, pR453, DOI 10.1016/j.cub.2014.03.034
   Sharma DR, 2009, TOXICOL APPL PHARM, V240, P208, DOI 10.1016/j.taap.2009.06.015
   Shim HY, 2007, MOL CELLS, V24, P95
   Shipp A, 2006, CRIT REV TOXICOL, V36, P481, DOI 10.1080/10408440600851377
   Shruthi, 2020, Int J Sci Eng Res, V6, DOI [10.7897/2230-8407.04301, DOI 10.7897/2230-8407.04301]
   Siegel RL, 2016, CA-CANCER J CLIN, V66, P7, DOI 10.3322/caac.21332
   Silva F, 2011, PHYTOMEDICINE, V19, P42, DOI 10.1016/j.phymed.2011.06.033
   Silva F, 2011, J MED MICROBIOL, V60, P1479, DOI 10.1099/jmm.0.034157-0
   Singh BK, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034200
   Singh G, 2006, FLAVOUR FRAG J, V21, P472, DOI 10.1002/ffj.1608
   Singletary K., 2016, Nutrition Today, V51, P151, DOI 10.1097/NT.0000000000000159
   Soares BV, 2012, MOLECULES, V17, P8439, DOI 10.3390/molecules17078439
   Gaston MS, 2016, PHARM BIOL, V54, P1954, DOI 10.3109/13880209.2015.1137602
   Song BL, 2006, J BIOL CHEM, V281, P25054, DOI 10.1074/jbc.M605575200
   Sriti J, 2010, J AM OIL CHEM SOC, V87, P395, DOI 10.1007/s11746-009-1505-1
   Sriti J, 2009, J SCI FOOD AGR, V89, P1659, DOI 10.1002/jsfa.3637
   Sultana S, 2010, Pak J Biol Sci, V13, P340, DOI 10.3923/pjbs.2010.340.343
   Sumizawa T, 2007, ARCH TOXICOL, V81, P279, DOI 10.1007/s00204-006-0145-6
   Suwanjang W, 2017, ASIAN PAC J TROP MED, V10, P35, DOI 10.1016/j.apjtm.2016.11.012
   SWANSTONFLATT SK, 1990, DIABETOLOGIA, V33, P462, DOI 10.1007/BF00405106
   Taherian AA, 2012, IRAN J PHARM RES, V11, P679
   Tahraoui A, 2007, J ETHNOPHARMACOL, V110, P105, DOI 10.1016/j.jep.2006.09.011
   TAKANO S, 1981, CANCER RES, V41, P624
   Tang ELH, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-347
   Tanida M, 2006, NEUROSCI LETT, V398, P155, DOI 10.1016/j.neulet.2005.12.076
   Taniguchi M, 1996, PHYTOCHEMISTRY, V42, P843, DOI 10.1016/0031-9422(95)00930-2
   Tankam JM, 2013, BIOL PHARM BULL, V36, P1608, DOI 10.1248/bpb.b13-00491
   Thabrew MI, 2003, J ETHNOPHARMACOL, V85, P261, DOI 10.1016/S0378-8741(03)00016-3
   Tian LY, 2010, PHYTOMEDICINE, V17, P533, DOI 10.1016/j.phymed.2009.10.007
   Tolardo R, 2010, J ETHNOPHARMACOL, V128, P63, DOI 10.1016/j.jep.2009.12.026
   Turek C, 2013, COMPR REV FOOD SCI F, V12, P40, DOI 10.1111/1541-4337.12006
   Turnbach ME, 2002, PAIN, V97, P127, DOI 10.1016/S0304-3959(02)00012-X
   Udayakumar R, 2009, INT J MOL SCI, V10, P2367, DOI 10.3390/ijms10052367
   Ugulu I, 2009, J MED PLANTS RES, V3, P345
   Umar A, 2010, HYPERTENS RES, V33, P727, DOI 10.1038/hr.2010.64
   Usta J, 2009, CHEM-BIOL INTERACT, V180, P39, DOI 10.1016/j.cbi.2009.02.012
   Vanhoutte PM, 2009, ACTA PHYSIOL, V196, P193, DOI 10.1111/j.1748-1716.2009.01964.x
   Vatanparast J, 2006, COMP BIOCHEM PHYS C, V143, P464, DOI 10.1016/j.cbpc.2006.04.008
   Vatanparast J, 2017, COMP BIOCHEM PHYS C, V192, P33, DOI 10.1016/j.cbpc.2016.12.004
   Vázquez-López A, 2005, NEUROCHEM RES, V30, P613, DOI 10.1007/s11064-005-2748-3
   Venáncio AM, 2011, REV BRAS FARMACOGN, V21, P1043, DOI 10.1590/S0102-695X2011005000147
   Visioli F, 2001, Curr Atheroscler Rep, V3, P64, DOI 10.1007/s11883-001-0012-0
   Waheed A., 2006, Pak. J. Pharmacol, V23, P7
   Wangensteen H, 2004, FOOD CHEM, V88, P293, DOI 10.1016/j.foodchem.2004.01.047
   White HS, 2007, INT REV NEUROBIOL, V81, P85, DOI 10.1016//S0074-7742(06)81006-8
   Wilson PWF, 2005, CIRCULATION, V112, P3066, DOI 10.1161/CIRCULATIONAHA.105.539528
   Witt CM, 2009, J ALTERN COMPLEM MED, V15, P59, DOI 10.1089/acm.2008.0176
   Wongsawatkul O, 2008, INT J MOL SCI, V9, P2724, DOI 10.3390/ijms9122724
   Wu TT, 2010, J SCI FOOD AGR, V90, P1846, DOI 10.1002/jsfa.4023
   Wuwongse S, 2010, PROG NEUROBIOL, V91, P362, DOI 10.1016/j.pneurobio.2010.04.005
   Youdim KA, 2004, FREE RADICAL BIO MED, V37, P1683, DOI 10.1016/j.freeradbiomed.2004.08.002
   Zardini HZ, 2012, GOMAL J MED SCI, V10, P167
   Zhang CR, 2015, FOOD CHEM, V167, P24, DOI 10.1016/j.foodchem.2014.06.120
   Zhang N, 2016, PHYTOMEDICINE, V23, P1727, DOI 10.1016/j.phymed.2016.10.017
   Zhang XC, 2007, J PHARMACOL EXP THER, V322, P806, DOI 10.1124/jpet.107.123745
   Zheljazkov VD, 2008, IND CROP PROD, V28, P88, DOI 10.1016/j.indcrop.2008.01.011
   Zhu YJ, 2008, NEUROCHEM RES, V33, P2310, DOI 10.1007/s11064-008-9730-9
   Zoubiri S, 2010, FOOD CHEM, V122, P1226, DOI 10.1016/j.foodchem.2010.03.119
NR 293
TC 102
Z9 105
U1 4
U2 84
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0963-9969
EI 1873-7145
J9 FOOD RES INT
JI Food Res. Int.
PD MAR
PY 2018
VL 105
BP 305
EP 323
DI 10.1016/j.foodres.2017.11.019
PG 19
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA FW8GJ
UT WOS:000425567900032
PM 29433220
DA 2025-06-11
ER

PT J
AU Shibata, S
   Fujita, T
AF Shibata, Shigeru
   Fujita, Toshiro
TI The Kidneys and Aldosterone/Mineralocorticoid Receptor System in
   Salt-Sensitive Hypertension
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
DE Aldosterone; Mineralocorticoid receptor; Alternative pathway; Rac1;
   Salt-sensitive hypertension; Metabolic syndrome
ID EPITHELIAL SODIUM-CHANNEL; BLOOD-PRESSURE; MINERALOCORTICOID RECEPTOR;
   PRIMARY ALDOSTERONISM; OXIDATIVE STRESS; NA+ CHANNEL; ACTIVATION; SGK1;
   KINASE; RATS
AB Strong evidence supports the ability of the aldosterone/mineralocorticoid receptor (MR) system to dominate long-term blood pressure control. It is also increasingly recognized as an important mediator of cardiovascular and renal diseases, particularly in the presence of excessive salt intake. In a subgroup of individuals with metabolic syndrome, adipocyte-derived aldosterone-releasing factors cause inappropriate secretion of aldosterone in the adrenal glands during salt loading, resulting in the development of salt-induced hypertension and cardiac and renal damage. On the other hand, emerging data reveal that aldosterone is not a sole regulator of MR activity. We have identified the signaling crosstalk between MR and small GTPase Rac1 as a novel pathway to facilitate MR signaling. Such a local control system for MR can also be relevant to the pathogenesis of salt-sensitive hypertension, and future studies will clarify the detailed mechanism for the intricate regulation of the aldosterone/MR cascade.
C1 [Shibata, Shigeru; Fujita, Toshiro] Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Bunkyo Ku, Tokyo 1138655, Japan.
C3 University of Tokyo
RP Fujita, T (corresponding author), Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM ssiba-tky@umin.ac.jp; fujita-dis@h.u-tokyo.ac.jp
OI Shibata, Shigeru/0000-0002-6868-0626
CR [Anonymous], 1988, BMJ, V297, P319
   Ayroldi E, 2002, MOL CELL BIOL, V22, P7929, DOI 10.1128/MCB.22.22.7929-7941.2002
   Bentley-Lewis R, 2007, J CLIN ENDOCR METAB, V92, P4472, DOI 10.1210/jc.2007-1088
   Bhalla V, 2006, AM J PHYSIOL-RENAL, V291, pF714, DOI 10.1152/ajprenal.00061.2006
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Chen J, 2009, LANCET, V373, P829, DOI 10.1016/S0140-6736(09)60144-6
   DAHL LK, 1975, CIRC RES, V36, P692, DOI 10.1161/01.RES.36.6.692
   DENTON D, 1995, NAT MED, V1, P1009, DOI 10.1038/nm1095-1009
   Diakov A, 2004, J BIOL CHEM, V279, P38134, DOI 10.1074/jbc.M403260200
   Doi M, 2010, NAT MED, V16, P67, DOI 10.1038/nm.2061
   Ehrhart-Bornstein M, 2003, P NATL ACAD SCI USA, V100, P14211, DOI 10.1073/pnas.2336140100
   Farjah M, 2003, HYPERTENSION, V41, P874, DOI 10.1161/01.HYP.0000063885.48344.EA
   Farquharson CAJ, 2002, CLIN SCI, V103, P425, DOI 10.1042/cs1030425
   FUJITA T, 1980, AM J MED, V69, P334, DOI 10.1016/0002-9343(80)90002-9
   Guilluy C, 2010, NAT MED, V16, P183, DOI 10.1038/nm.2079
   GUYTON AC, 1991, SCIENCE, V252, P1813, DOI 10.1126/science.2063193
   HALL JE, 1990, HYPERTENSION, V15, P547, DOI 10.1161/01.HYP.15.6.547
   Heise CJ, 2010, J BIOL CHEM, V285, P25161, DOI 10.1074/jbc.M110.103432
   KIMURA G, 1987, HYPERTENSION, V10, P11, DOI 10.1161/01.HYP.10.1.11
   Krug AW, 2010, HYPERTENSION, V55, P1476, DOI 10.1161/HYPERTENSIONAHA.109.148783
   Lee SH, 2009, AM J PHYSIOL-RENAL, V297, pF1381, DOI 10.1152/ajprenal.00101.2009
   Leroy V, 2009, J AM SOC NEPHROL, V20, P131, DOI 10.1681/ASN.2008020232
   Lifton RP, 2001, CELL, V104, P545, DOI 10.1016/S0092-8674(01)00241-0
   LIFTON RP, 1992, NATURE, V355, P262, DOI 10.1038/355262a0
   Lin S, 2010, J RENIN-ANGIO-ALDO S, V11, P149, DOI 10.1177/1470320310369603
   Mihailidou AS, 2009, HYPERTENSION, V54, P1306, DOI 10.1161/HYPERTENSIONAHA.109.136242
   Morimoto A, 1997, LANCET, V350, P1734, DOI 10.1016/S0140-6736(97)05189-1
   Nagai Y, 2005, HYPERTENSION, V46, P1039, DOI 10.1161/01.HYP.0000174593.88899.68
   Nagase M, 2007, HYPERTENSION, V50, P877, DOI 10.1161/HYPERTENSIONAHA.107.091058
   Nagase M, 2006, HYPERTENSION, V47, P1084, DOI 10.1161/01.HYP.0000222003.28517.99
   Náray-Fejes-Tóth A, 2004, P NATL ACAD SCI USA, V101, P17434, DOI 10.1073/pnas.0408146101
   Newhouse SJ, 2005, HUM MOL GENET, V14, P1805, DOI 10.1093/hmg/ddi187
   Pitt B, 2003, NEW ENGL J MED, V348, P1309, DOI 10.1056/NEJMoa030207
   Pitt B, 1999, NEW ENGL J MED, V341, P709, DOI 10.1056/NEJM199909023411001
   Quinkler M, 2005, CIRCULATION, V112, P1435, DOI 10.1161/CIRCULATIONAHA.105.539122
   Ring AM, 2007, P NATL ACAD SCI USA, V104, P4025, DOI 10.1073/pnas.0611728104
   Rossi GP, 2006, HYPERTENSION, V48, P232, DOI 10.1161/01.HYP.0000230444.01215.6a
   Rossi GP, 2006, J AM COLL CARDIOL, V48, P2293, DOI 10.1016/j.jacc.2006.07.059
   Rozansky DJ, 2009, J CLIN INVEST, V119, P2601, DOI 10.1172/JCI38323
   Shibata S, 2007, HYPERTENSION, V49, P355, DOI 10.1161/01.HYP.0000255636.11931.a2
   Shibata S, 2008, NAT MED, V14, P1370, DOI 10.1038/nm.1879
   SHIMKETS RA, 1994, CELL, V79, P407, DOI 10.1016/0092-8674(94)90250-X
   Soundararajan R, 2009, P NATL ACAD SCI USA, V106, P7804, DOI 10.1073/pnas.0809892106
   Takai Y, 2001, PHYSIOL REV, V81, P153, DOI 10.1152/physrev.2001.81.1.153
   Williams GH, 2004, AM J CARDIOL, V93, P990, DOI 10.1016/j.amjcard.2004.01.007
   Wilson FH, 2001, SCIENCE, V293, P1107, DOI 10.1126/science.1062844
   Wu XM, 2008, CELL, V133, P340, DOI 10.1016/j.cell.2008.01.052
   Yokota K, 2007, J BIOL CHEM, V282, P1998, DOI 10.1074/jbc.M607741200
   Zennaro MC, 2001, MOL ENDOCRINOL, V15, P1586, DOI 10.1210/me.15.9.1586
   Zhang WZ, 2007, J CLIN INVEST, V117, P773, DOI 10.1172/JCI29850
NR 50
TC 21
Z9 25
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD APR
PY 2011
VL 13
IS 2
BP 109
EP 115
DI 10.1007/s11906-010-0175-6
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 729CM
UT WOS:000287925700004
PM 21207253
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Davis, MC
   Lemery-Chalfant, K
   Yeung, EW
   Luecken, LJ
   Zautra, AJ
   Irwin, MR
AF Davis, Mary C.
   Lemery-Chalfant, Kathryn
   Yeung, Ellen WanHeung
   Luecken, Linda J.
   Zautra, Alex J.
   Irwin, Michael R.
TI Interleukin-6 and Depressive Mood Symptoms: Mediators of the Association
   Between Childhood Abuse and Cognitive Performance in Middle-Aged Adults
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Childhood abuse; Depression; Metabolic risk; Inflammation;
   Interleukin-6; Cognitive function
ID EARLY-LIFE ADVERSITY; C-REACTIVE PROTEIN; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; INFLAMMATION; DECLINE; STRESS; MARKERS; HEALTH; RISK
AB Background Childhood abuse is a risk factor for the development of cognitive deficits in adulthood, a relation that is likely mediated by stress-sensitive psychological and physiological indicators.
   Purpose To evaluate whether the link between exposure to childhood abuse and cognitive function in middle adulthood is mediated by interleukin-6 (IL-6), metabolic risk, and depressive mood symptoms.
   Methods Participants were 770 adults aged 40-65 recruited from the community, who completed the following: (i) a questionnaire assessing exposure to abuse prior to age 18, (ii) a phone interview assessing current depressive mood symptoms, and (iii) a home visit that included blood sampling for evaluation of IL-6 and assessment of metabolic risk indices. A follow-up telephone assessment evaluating cognitive function was completed by 555 of the participants. Structural equation modeling was used to test study hypotheses.
   Results Childhood abuse predicted higher levels of IL-6, depressive mood symptoms, and metabolic risk scores (p < .05). The relation between childhood abuse and poorer cognitive performance was mediated by IL-6 (p = .046) and depressive mood symptoms (p = .023), but not metabolic risk. IL-6 and depressive mood symptoms significantly mediated the relation between childhood abuse and adult cognitive function.
   Conclusions Exposure to early abuse conveys enduring physiological and psychological effects, which may contribute to cognitive deficits that are evident by middle adulthood. Increased vulnerability for cognitive decline among adults with a history of early trauma and the mediating roles of IL-6 and depressive mood symptoms point to the potential value of interventions that address inflammation or depression, singly or together, to prevent cognitive decline in this at-risk population.
C1 [Davis, Mary C.; Lemery-Chalfant, Kathryn; Luecken, Linda J.; Zautra, Alex J.] Arizona State Univ, Dept Psychol, Box 871104, Tempe, AZ 85287 USA.
   [Yeung, Ellen WanHeung] Univ Missouri, Dept Psychol Sci, Columbia, MO USA.
   [Irwin, Michael R.] Univ Calif Los Angeles, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA USA.
   [Irwin, Michael R.] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA.
C3 Arizona State University; Arizona State University-Tempe; University of
   Missouri System; University of Missouri Columbia; University of
   California System; University of California Los Angeles; University of
   California System; University of California Los Angeles
RP Davis, MC (corresponding author), Arizona State Univ, Dept Psychol, Box 871104, Tempe, AZ 85287 USA.
EM mary.davis@asu.edu
RI Luecken, Linda/K-6891-2013; Irwin, Michael/H-4870-2013
OI Irwin, Michael/0000-0002-1502-8431; Luecken, Linda/0000-0001-9383-1986;
   Lemery-Chalfant, Kathryn/0000-0003-4511-6501
FU National Institute on Aging [R01AG026006]; Eunice K. Shriver National
   Institute of Child Health and Human Development [R01HD086085]; National
   Institute on Alcohol Abuse and Alcoholism [T32AA013526]
FX This work was supported by funding from the National Institute on Aging
   (R01AG026006), the Eunice K. Shriver National Institute of Child Health
   and Human Development (R01HD086085), and the National Institute on
   Alcohol Abuse and Alcoholism (T32AA013526).
CR [Anonymous], 2008, Physical Activity Guidelines Advisory Committee Report, 2008
   Anstey KJ, 2007, AM J EPIDEMIOL, V166, P367, DOI 10.1093/aje/kwm116
   Bastien CH, 2001, SLEEP MED, V2, P297, DOI 10.1016/S1389-9457(00)00065-4
   Baumeister D, 2016, MOL PSYCHIATR, V21, P642, DOI 10.1038/mp.2015.67
   Bernstein DP, 2003, CHILD ABUSE NEGLECT, V27, P169, DOI 10.1016/S0145-2134(02)00541-0
   Brenhouse HC, 2011, BIOL PSYCHIAT, V70, P434, DOI 10.1016/j.biopsych.2011.05.006
   Brunson KL, 2005, J NEUROSCI, V25, P9328, DOI 10.1523/JNEUROSCI.2281-05.2005
   Bush NR, 2016, PSYCHOSOM MED, V78, P1114, DOI 10.1097/PSY.0000000000000421
   Chaiton MO, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-356
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Coelho R, 2014, ACTA PSYCHIAT SCAND, V129, P180, DOI 10.1111/acps.12217
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   Cricco M, 2001, J AM GERIATR SOC, V49, P1185, DOI 10.1046/j.1532-5415.2001.49235.x
   Danese A, 2007, P NATL ACAD SCI USA, V104, P1319, DOI 10.1073/pnas.0610362104
   Danese A, 2009, ARCH PEDIAT ADOL MED, V163, P1135, DOI 10.1001/archpediatrics.2009.214
   Davis MC, 2008, BRAIN BEHAV IMMUN, V22, P24, DOI 10.1016/j.bbi.2007.06.013
   Dunn EC, 2016, CHILD ABUSE NEGLECT, V51, P181, DOI 10.1016/j.chiabu.2015.10.014
   Economos A, 2013, NEUROEPIDEMIOLOGY, V40, P253, DOI 10.1159/000343276
   Enders C.K., 2010, Applied missing data analysis
   Fergusson DM, 2011, INT J METH PSYCH RES, V20, P93, DOI 10.1002/mpr.337
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Gorelick PB, 2010, ANN NY ACAD SCI, V1207, P155, DOI 10.1111/j.1749-6632.2010.05726.x
   Gould F, 2012, J PSYCHIATR RES, V46, P500, DOI 10.1016/j.jpsychires.2012.01.005
   Grassi-Oliveira R, 2016, PSYCHONEUROENDOCRINO, V71, P19, DOI 10.1016/j.psyneuen.2016.04.016
   Heim C, 2001, BIOL PSYCHIAT, V49, P1023, DOI 10.1016/S0006-3223(01)01157-X
   Hennessy MB, 2001, DEV PSYCHOBIOL, V39, P76, DOI 10.1002/dev.1031
   Holsboer F, 2000, NEUROPSYCHOPHARMACOL, V23, P477, DOI 10.1016/S0893-133X(00)00159-7
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Irwin MR, 2015, ANNU REV PSYCHOL, V66, P143, DOI 10.1146/annurev-psych-010213-115205
   Kendall-Tackett K, 2002, CHILD ABUSE NEGLECT, V26, P715, DOI 10.1016/S0145-2134(02)00343-5
   Komulainen P, 2007, DEMENT GERIATR COGN, V23, P29, DOI 10.1159/000096636
   Lopez Oscar L, 2010, Neuroepidemiology, V34, P63, DOI 10.1159/000264678
   Luecken LJ, 2006, J SOC CLIN PSYCHOL, V25, P33, DOI 10.1521/jscp.2006.25.1.33
   Lupien SJ, 2009, NAT REV NEUROSCI, V10, P434, DOI 10.1038/nrn2639
   MacKinnon D. P., 2008, INTRO STAT MEDIATION, DOI [10.4324/9780203809556, DOI 10.4324/9780203809556]
   Mackinnon David P, 2004, Multivariate Behav Res, V39, P99
   Majer M, 2010, BMC NEUROL, V10, DOI 10.1186/1471-2377-10-61
   Manly JJ, 2011, ARCH NEUROL-CHICAGO, V68, P607, DOI 10.1001/archneurol.2011.88
   Matthews KA, 2010, BRAIN BEHAV IMMUN, V24, P96, DOI 10.1016/j.bbi.2009.08.005
   Miller GE, 2011, PSYCHOL BULL, V137, P959, DOI 10.1037/a0024768
   Muthen B. O., 1998, MPLUS USERS GUIDE
   Nikulina V, 2013, NEUROPSYCHOLOGY, V27, P417, DOI 10.1037/a0032811
   Paljärvi T, 2009, ADDICTION, V104, P1168, DOI 10.1111/j.1360-0443.2009.02577.x
   Rafnsson SB, 2007, J AM GERIATR SOC, V55, P700, DOI 10.1111/j.1532-5415.2007.01158.x
   SAUNDERS JB, 1993, ADDICTION, V88, P791, DOI 10.1111/j.1360-0443.1993.tb02093.x
   Scher CD, 2001, J TRAUMA STRESS, V14, P843, DOI 10.1023/A:1013058625719
   Schram MT, 2007, J AM GERIATR SOC, V55, P708, DOI 10.1111/j.1532-5415.2007.01159.x
   Seo EH, 2011, ARCH GERONTOL GERIAT, V52, pE26, DOI 10.1016/j.archger.2010.04.008
   Singh-Manoux A, 2014, NEUROLOGY, V83, P486, DOI 10.1212/WNL.0000000000000665
   Snyder HR, 2013, PSYCHOL BULL, V139, P81, DOI 10.1037/a0028727
   Sofi F, 2011, J INTERN MED, V269, P107, DOI 10.1111/j.1365-2796.2010.02281.x
   Teunissen CE, 2003, J NEUROIMMUNOL, V134, P142, DOI 10.1016/S0165-5728(02)00398-3
   VEIT CT, 1983, J CONSULT CLIN PSYCH, V51, P730, DOI 10.1037/0022-006X.51.5.730
   Walker EA, 1999, AM J MED, V107, P332, DOI 10.1016/S0002-9343(99)00235-1
   Weaver JD, 2002, NEUROLOGY, V59, P371, DOI 10.1212/WNL.59.3.371
   Wieck A, 2013, BRAIN BEHAV IMMUN, V28, P218, DOI 10.1016/j.bbi.2012.11.012
   Yaffe K, 2004, JAMA-J AM MED ASSOC, V292, P2237, DOI 10.1001/jama.292.18.2237
NR 57
TC 23
Z9 25
U1 0
U2 11
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD JAN
PY 2019
VL 53
IS 1
BP 29
EP 38
DI 10.1093/abm/kay014
PG 10
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA IQ5NE
UT WOS:000480798700003
PM 29562248
OA Green Published
DA 2025-06-11
ER

PT J
AU Vesoulis, ZA
   Diggs, S
   Brackett, C
   Sullivan, B
AF Vesoulis, Zachary A.
   Diggs, Stephanie
   Brackett, Cherise
   Sullivan, Brynne
TI Racial and geographic disparities in neonatal brain care
SO SEMINARS IN PERINATOLOGY
LA English
DT Review
DE Neonatal; Brain injury; IVH; Cerebral palsy; Racial disparities;
   Outcomes
ID ARTERIAL BLOOD-PRESSURE; INTRAVENTRICULAR HEMORRHAGE; PRETERM BIRTH;
   METABOLIC SYNDROME; PREMATURE-INFANTS; CEREBRAL-PALSY; UNITED-STATES;
   RISK-FACTORS; ETHNIC DISPARITIES; MATERNAL EDUCATION
AB In this review, we explore race-based disparities in neonatology and their impact on brain injury and neurodevelopmental outcomes. We discuss the historical context of healthcare discrimination, focusing on the postCivil War era and the segregation of healthcare facilities. We highlight the increasing disparity in infant mortality rates between Black and White infants, with premature birth being a major contributing factor, and emphasize the role of prenatal factors such as metabolic syndrome and toxic stress in affecting neonatal health. Furthermore, we examine the geographic and historical aspects of racial disparities, including the consequences of redlining and limited access to healthcare facilities or nutritious food options in Black communities. Finally, we delve into the higher incidence of brain injuries in Black neonates, as well as disparities in adverse neurodevelopmental outcome. This evidence underscores the need for comprehensive efforts to address systemic racism and provide equitable access to healthcare resources.
C1 [Vesoulis, Zachary A.; Diggs, Stephanie] Washington Univ, Sch Med, Dept Pediat, Div Newborn Med, St Louis, MO USA.
   [Brackett, Cherise; Sullivan, Brynne] Univ Virginia, Dept Pediat, Div Neonatol, Charlottesville, VA USA.
C3 Washington University (WUSTL); University of Virginia
RP Vesoulis, ZA (corresponding author), 660 S Euclid Ave,Campus Box 8116, St Louis, MO 63110 USA.
EM vesoulis_z@wustl.edu
RI Vesoulis, Zachary/J-1879-2019; Sullivan, Brynne/MIT-9690-2025
CR Acun C, 2022, AM J OBSTET GYNECOL, V227, DOI 10.1016/j.ajog.2022.06.002
   ADAMSON SJ, 1995, BRIT MED J, V311, P598, DOI 10.1136/bmj.311.7005.598
   Adler I, 2010, J CLIN ULTRASOUND, V38, P254, DOI 10.1002/jcu.20683
   Al-Hamad D, 2017, TRANSL PEDIATR, V6, P397, DOI 10.21037/tp.2017.10.02
   An B., 2019, SSRN Electron. J., DOI [10.2139/ssrn.3500612, DOI 10.2139/SSRN.3500612]
   An Yeokwang, Small and medium multifamily housing units: affordability, distribution, and trends, DOI [10.13140/RG.2.2.18740.14722, DOI 10.13140/RG.2.2.18740.14722]
   Andrews WW, 2008, AM J OBSTET GYNECOL, V198, DOI 10.1016/j.ajog.2007.12.031
   [Anonymous], 2018, The Color of Medicine: The Story of Homer G. Phillips Hospital
   [Anonymous], 2003, When Children Die: Improving Palliative and End-of-Life Care for Children and Their Families, P10390, DOI [10.17226/10390, DOI 10.17226/10390]
   Ansari B, 2022, JMIR PUBLIC HLTH SUR, V8, DOI 10.2196/38037
   Asztalos EV, 2017, AM J PERINAT, V34, P388, DOI 10.1055/s-0036-1592129
   Aye ILMH, 2013, CHEM-BIOL INTERACT, V203, P456, DOI 10.1016/j.cbi.2013.03.007
   Bach PB, 2004, NEW ENGL J MED, V351, P575, DOI 10.1056/NEJMsa040609
   Back SA, 2017, ACTA NEUROPATHOL, V134, P331, DOI 10.1007/s00401-017-1718-6
   BADA HS, 1990, J PEDIATR-US, V117, P607, DOI 10.1016/S0022-3476(05)80700-0
   Bailey ZD, 2021, NEW ENGL J MED, V384, P768, DOI 10.1056/NEJMms2025396
   Ballabh P, 2010, PEDIATR RES, V67, P1, DOI 10.1203/PDR.0b013e3181c1b176
   Boghossian NS, 2019, PEDIATRICS, V144, DOI 10.1542/peds.2019-1106
   Bolisetty S, 2014, PEDIATRICS, V133, P55, DOI 10.1542/peds.2013-0372
   Bowers K, 2018, PSYCHONEUROENDOCRINO, V95, P145, DOI 10.1016/j.psyneuen.2018.05.024
   BRANDT AM, 1978, HASTINGS CENT REP, V8, P21, DOI 10.2307/3561468
   Branham DK, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2022.16715
   Braveman P, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0186151
   Brumbaugh JE, 2023, J PEDIATR-US, V259, DOI 10.1016/j.jpeds.2023.113443
   Bulatao R.A., 2004, UNDERSTANDING RACIAL
   Buss C, 2012, P NATL ACAD SCI USA, V109, pE1312, DOI 10.1073/pnas.1201295109
   Byrne R, 2017, PEDIATR NEUROL, V76, P66, DOI 10.1016/j.pediatrneurol.2017.08.002
   Chatzi L, 2009, AM J EPIDEMIOL, V170, P829, DOI 10.1093/aje/kwp211
   Chau V, 2014, CURR PEDIATR REV, V10, P28, DOI 10.2174/157339631001140408120336
   Chau V, 2014, CLIN PERINATOL, V41, P83, DOI 10.1016/j.clp.2013.10.009
   Cheong JLY, 2012, J PAEDIATR CHILD H, V48, P784, DOI 10.1111/j.1440-1754.2012.02536.x
   Cherian S, 2004, BRAIN PATHOL, V14, P305
   Christensen Peter., 2020, National Bureau of Economic Research, DOI DOI 10.3386/W26805
   Clifford J., 2017, CURRENT DEVELOPMENTA, DOI [DOI 10.1007/S40474-017-0121-2, 10.1007/s40474-017-0121-2]
   Cnattingius S, 2013, JAMA-J AM MED ASSOC, V309, P2362, DOI 10.1001/jama.2013.6295
   Condon EM, 2019, WESTERN J NURS RES, V41, P872, DOI 10.1177/0193945918788676
   COONEY JP, 1985, MED CARE, V23, P986, DOI 10.1097/00005650-198508000-00006
   Cornier MA, 2008, ENDOCR REV, V29, P777, DOI 10.1210/er.2008-0024
   Dai DJ, 2010, HEALTH PLACE, V16, P1038, DOI 10.1016/j.healthplace.2010.06.012
   Dai LL, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0113377
   Davis EP, 2017, PSYCHONEUROENDOCRINO, V75, P56, DOI 10.1016/j.psyneuen.2016.10.005
   de Vries LS, 2010, NEURORADIOLOGY, V52, P555, DOI 10.1007/s00234-010-0674-9
   Durkin MS, 2015, DEV MED CHILD NEUROL, V57, P835, DOI 10.1111/dmcn.12746
   DYKES FD, 1989, J PEDIATR-US, V114, P611, DOI 10.1016/S0022-3476(89)80707-3
   Edwards AD, 2010, BMJ-BRIT MED J, V340, DOI 10.1136/bmj.c363
   Ehrenberg HM, 2004, AM J OBSTET GYNECOL, V191, P964, DOI 10.1016/j.ajog.2004.05.052
   Eisenhauer E., 2001, GeoJournal, V53, P125, DOI 10.1023/A:1015772503007
   Ekeke P, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17196941
   El-Dib I, 2025, J RACIAL ETHN HEALTH, V12, P447, DOI 10.1007/s40615-023-01884-z
   Elliott T, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2022.34453
   Evans N, 1996, ARCH DIS CHILD-FETAL, V75, pF183, DOI 10.1136/fn.75.3.F183
   Fasching-Varner KJ, 2018, #BRokenPromises, Black Deaths, & Blue Ribbons: Understanding, Complicating, and Transcending Police-Community Violence
   Fraiman YS, 2022, J PERINATOL, V42, P217, DOI 10.1038/s41372-021-01188-2
   Gaillard TR, 2018, FRONT ENDOCRINOL, V8, DOI 10.3389/fendo.2017.00383
   Gamble VanessaNorthington., 1995, Making a Place for Ourselves: The Black Hospital Movement, 1920-1945
   Gee GC, 2011, DU BOIS REV, V8, P115, DOI 10.1017/S1742058X11000130
   Ghosh-Dastidar B, 2014, AM J PREV MED, V47, P587, DOI 10.1016/j.amepre.2014.07.005
   Girardi G, 2022, METAB SYNDR RELAT D, V20, P251, DOI 10.1089/met.2021.0124
   Glover V, 2020, WORLD PSYCHIATRY, V19, P331, DOI 10.1002/wps.20777
   Graham EM, 2008, AM J OBSTET GYNECOL, V199, P587, DOI 10.1016/j.ajog.2008.06.094
   Greenwood BN, 2020, P NATL ACAD SCI USA, V117, P21194, DOI 10.1073/pnas.1913405117
   Grieger JA, 2018, PLOS MED, V15, DOI 10.1371/journal.pmed.1002710
   Grissom JA, 2016, AERA OPEN, V2, DOI 10.1177/2332858415622175
   Grunebaum A, 2020, AM J OBSTET GYNECOL, V223, P933, DOI 10.1016/j.ajog.2020.07.015
   Han VX, 2021, TRANSL PSYCHIAT, V11, DOI 10.1038/s41398-021-01198-w
   Harding JF, 2015, J MARRIAGE FAM, V77, P60, DOI 10.1111/jomf.12156
   Hill AJ, 2023, J HEALTH ECON, V92, DOI 10.1016/j.jhealeco.2023.102821
   Hillier AE, 2003, J URBAN HIST, V29, P394, DOI 10.1177/0096144203029004002
   Hinrichs C.C., 2008, Remaking the North American Food System: Strategies for Sustainability
   Hintz SR, 2019, J PEDIATR-US, V210, P91, DOI 10.1016/j.jpeds.2019.03.007
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Howell EA, 2018, CLIN OBSTET GYNECOL, V61, P387, DOI 10.1097/GRF.0000000000000349
   Jackson MI, 2017, ANN AM ACAD POLIT SS, V674, P59, DOI 10.1177/0002716217729471
   Jansen T, 2018, BMC HEALTH SERV RES, V18, DOI 10.1186/s12913-018-3197-4
   Joseph RM, 2018, PEDIATR RES, V83, P767, DOI 10.1038/pr.2017.267
   Kelly MM, 2019, NURS RES, V68, P275, DOI 10.1097/NNR.0000000000000360
   Kim J, 2021, J PREV MED PUBLIC HL, V54, P208, DOI 10.3961/jpmph.20.625
   Kind AJH, 2018, NEW ENGL J MED, V378, P2456, DOI 10.1056/NEJMp1802313
   Kuppala VS, 2012, J PERINATOL, V32, P293, DOI 10.1038/jp.2011.97
   Kurinczuk JJ, 2010, EARLY HUM DEV, V86, P329, DOI 10.1016/j.earlhumdev.2010.05.010
   Labgold K, 2021, EPIDEMIOLOGY, V32, P157, DOI 10.1097/EDE.0000000000001314
   Largent EA, 2018, PUBLIC HEALTH REP, V133, P715, DOI 10.1177/0033354918795891
   Lee JY, 2010, J KOREAN MED SCI, V25, P418, DOI 10.3346/jkms.2010.25.3.418
   Leith WM, 2024, ANN EPIDEMIOL, V89, P29, DOI 10.1016/j.annepidem.2023.11.011
   Leventhal-Weiner R, 2011, RES SOC STRAT MOBIL, V29, P393, DOI 10.1016/j.rssm.2010.12.007
   LEVITON A, 1989, PEDIATRICS, V84, P915
   Liebowitz M, 2016, J PEDIATR-US, V177, P114, DOI 10.1016/j.jpeds.2016.07.002
   Lin SC, 2023, JAMA-HEALTH FORUM, V4, DOI 10.1001/jamahealthforum.2023.4172
   Linder N, 2003, PEDIATRICS, V111, pE590, DOI 10.1542/peds.111.5.e590
   Locke DH, 2021, NPJ URBAN SUSTAIN, V1, DOI 10.1038/s42949-021-00022-0
   Lowe JR, 2013, ACTA PAEDIATR, V102, P896, DOI 10.1111/apa.12310
   Maenner MJ, 2012, EPIDEMIOLOGY, V23, P35, DOI 10.1097/EDE.0b013e31823a4205
   Martin AE, 2016, J PERINATOL, V36, P1001, DOI 10.1038/jp.2016.142
   Masters JR, 2002, NAT REV CANCER, V2, P315, DOI 10.1038/nrc775
   Matoba N, 2017, SEMIN PERINATOL, V41, P354, DOI 10.1053/j.semperi.2017.07.003
   McCarty DB, 2023, ADV NEONAT CARE, V23, P31, DOI 10.1097/ANC.0000000000000987
   Menon R, 2011, ACTA OBSTET GYN SCAN, V90, P1325, DOI 10.1111/j.1600-0412.2011.01135.x
   MENT LR, 1995, AM J OBSTET GYNECOL, V172, P795, DOI 10.1016/0002-9378(95)90001-2
   MIALLALLEN VM, 1987, ARCH DIS CHILD, V62, P1068, DOI 10.1136/adc.62.10.1068
   Michney TM, 2022, J PLAN HIST, V21, P316, DOI 10.1177/15385132211013361
   Miller SS, 2011, J PERINATOL, V31, pS49, DOI 10.1038/jp.2010.177
   Monk C, 2012, DEV PSYCHOPATHOL, V24, P1361, DOI 10.1017/S0954579412000764
   Murosko D, 2020, PEDIATRICS, V145, DOI 10.1542/peds.2019-1508
   Nakayama DK, 2021, Black Surg Surg Am, P141
   Nesterenko TH, 2009, AM J PERINAT, V26, P191, DOI 10.1055/s-0028-1103027
   Novak I, 2017, JAMA PEDIATR, V171, P897, DOI 10.1001/jamapediatrics.2017.1689
   PAPILE LA, 1983, J PEDIATR-US, V103, P273, DOI 10.1016/S0022-3476(83)80366-7
   Parchem JG, 2023, AM J PERINAT, V40, P557, DOI 10.1055/s-0041-1730348
   Patra K., 2014, e-JNR, V4, P3
   Peters SJ, 2022, GIFTED CHILD QUART, V66, P82, DOI 10.1177/00169862211002535
   Petrova Anna, 2003, J Perinatol, V23, P404, DOI 10.1038/sj.jp.7210934
   Profit J, 2017, PEDIATRICS, V140, DOI 10.1542/peds.2017-0918
   Qureshi AI, 2013, J NEUROSURG-PEDIATR, V12, P49, DOI 10.3171/2013.4.PEDS12568
   RABINOWITZ HN, 1974, SOC SERV REV, V48, P327, DOI 10.1086/643148
   Radulescu L, 2013, J Med Life, V6, P292
   Ravi D, 2021, SEMIN PERINATOL, V45, DOI 10.1016/j.semperi.2021.151411
   Rothstein R., 2017, government of America is generally the same as in Japan. There is a law code of twelve
   Schaaf JM, 2013, AM J PERINAT, V30, P433, DOI 10.1055/s-0032-1326988
   Schetter CD, 2012, CURR OPIN PSYCHIATR, V25, P141, DOI 10.1097/YCO.0b013e3283503680
   Shaker Y, 2023, AGR HUM VALUES, V40, P101, DOI 10.1007/s10460-022-10340-3
   Shankaran S, 2014, J PEDIATR-US, V164, P1005, DOI 10.1016/j.jpeds.2014.01.036
   Shankaran S, 2012, NEW ENGL J MED, V366, P2085, DOI 10.1056/NEJMoa1112066
   Shapiro H.S., 2005, Critical Social Issues in American Education, V3rd
   Sigurdson K, 2019, PEDIATRICS, V144, DOI 10.1542/peds.2018-3114
   Simmons LE, 2010, SEMIN PERINATOL, V34, P408, DOI 10.1053/j.semperi.2010.09.005
   Singh Gopal K, 2019, Int J MCH AIDS, V8, P19, DOI 10.21106/ijma.271
   Sosina VE, 2019, AERA OPEN, V5, DOI 10.1177/2332858419872445
   Stearns KL, 2021, AM J OBSTET GYNECOL, V224, pS559
   Stoll BJ, 2010, PEDIATRICS, V126, P443, DOI 10.1542/peds.2009-2959
   Stormacq C, 2019, HEALTH PROMOT INT, V34, pE1, DOI 10.1093/heapro/day062
   Sullivan BA, 2023, JAMA NETW OPEN, V6, DOI 10.1001/jamanetworkopen.2023.11761
   Swearingen C, 2020, J PERINATOL, V40, P790, DOI 10.1038/s41372-020-0659-4
   Tanne JH, 2023, BMJ-BRIT MED J, V383, DOI 10.1136/bmj.p2569
   Tin W, 1998, ARCH DIS CHILD-FETAL, V79, pF83, DOI 10.1136/fn.79.2.F83
   Travers CP, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.6757
   Travers CP, 2020, J PERINATOL, V40, P767, DOI 10.1038/s41372-020-0640-2
   Trivers Ian., 2015, Focus on Geography, V58, P199, DOI DOI 10.1111/FOGE.12065
   Vesoulis ZA, 2019, J PERINATOL, V39, P48, DOI 10.1038/s41372-018-0236-2
   VOLPE JJ, 1989, ANN NEUROL, V25, P3, DOI 10.1002/ana.410250103
   Walker RE, 2010, HEALTH PLACE, V16, P876, DOI 10.1016/j.healthplace.2010.04.013
   Wallace ME, 2017, AM J OBSTET GYNECOL, V216, DOI 10.1016/j.ajog.2016.11.1026
   WATKINS AMC, 1989, EARLY HUM DEV, V19, P103, DOI 10.1016/0378-3782(89)90120-5
   Watson Laura, 2021, Nurs Adm Q, V45, P302, DOI 10.1097/NAQ.0000000000000495
   Willoughby RE, 2002, CLIN PERINATOL, V29, P603, DOI 10.1016/S0095-5108(02)00058-1
   Wu YW, 2011, PEDIATRICS, V127, pE674, DOI 10.1542/peds.2010-1656
   Yearby R, 2022, HEALTH AFFAIR, V41, P187, DOI 10.1377/hlthaff.2021.01466
   Zhang MY, 2016, T GIS, V20, P79, DOI 10.1111/tgis.12142
NR 147
TC 0
Z9 0
U1 0
U2 1
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0146-0005
EI 1558-075X
J9 SEMIN PERINATOL
JI Semin. Perinatol.
PD AUG
PY 2024
VL 48
IS 5
AR 151925
DI 10.1016/j.semperi.2024.151925
EA AUG 2024
PG 8
WC Obstetrics & Gynecology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Pediatrics
GA C4J1O
UT WOS:001289028900001
PM 38897830
OA hybrid
DA 2025-06-11
ER

PT J
AU McMullen, S
   Langley-Evans, SC
   Gambling, L
   Lang, C
   Swali, A
   McArdle, HJ
AF McMullen, S.
   Langley-Evans, S. C.
   Gambling, L.
   Lang, C.
   Swali, A.
   McArdle, H. J.
TI A common cause for a common phenotype: The gatekeeper hypothesis in
   fetal programming
SO MEDICAL HYPOTHESES
LA English
DT Article
ID LOW-PROTEIN-DIET; RENIN-ANGIOTENSIN SYSTEM; INTRAUTERINE
   GROWTH-RETARDATION; PITUITARY-ADRENAL AXIS; HIGH BLOOD-PRESSURE; JUNK
   FOOD DIET; DEVELOPMENTAL ORIGINS; RAT PREGNANCY; EPIGENETIC
   MODIFICATION; METABOLIC SYNDROME
AB Sub-optimal nutrition during pregnancy has been shown to have long-term effects on the health of offspring in both humans and animals. The most common outcomes of such programming are hypertension, obesity, dyslipidaemia and insulin resistance. This spectrum of disorders, collectively known as metabolic syndrome, appears to be the consequence of nutritional insult during early development, irrespective of the nutritional stress experienced. For example, diets low in protein diet, high in fat, or deficient in iron are all associated with programming of cardiovascular and metabolic disorders when fed during rat pregnancy. In this paper, we hypothesise that the nutritional stresses act on genes or gene pathways common to all of the insults. We have termed these genes and/or gene pathways the "gatekeepers" and hence developed the "gatekeeper hypothesis". In this paper, we examine the background to the hypothesis and postulate some possible mechanisms or pathways that may constitute programming gatekeepers. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Gambling, L.; Lang, C.; McArdle, H. J.] Univ Aberdeen, Rowett Inst Nutr & Hlth, Aberdeen AB21 9SB, Scotland.
   [McMullen, S.; Langley-Evans, S. C.; Swali, A.] Univ Nottingham, Sch Biosci, Loughborough LE12 5RD, Leics, England.
C3 University of Aberdeen; University of Nottingham
RP McArdle, HJ (corresponding author), Univ Aberdeen, Rowett Inst Nutr & Hlth, Greenburn Rd, Aberdeen AB21 9SB, Scotland.
EM h.mcardle@abdn.ac.uk
RI Langley-Evans, Simon/AAR-4181-2020; McMullen, Sarah/H-8652-2012
OI Langley-Evans, Simon/0000-0002-1969-8416; Swali,
   Angelina/0000-0002-6428-6373
FU BBSRC; Rural and Environmental Analytical Service (RERAS) of Scottish
   Government; BBSRC [BB/F005245/1] Funding Source: UKRI
FX SLE and SM, in collaboration with HJM and LG, hold funding with the
   BBSRC for a project testing the gatekeeper hypothesis. AS was funded by
   the BBSRC. HJM, LG and CL are supported by Rural and Environmental
   Analytical Service (RERAS) of Scottish Government.
CR AGUILERA G, 1978, P NATL ACAD SCI USA, V75, P4057, DOI 10.1073/pnas.75.8.4057
   Akyol A, 2011, BRIT J NUTR IN PRESS, DOI [10 10171/s00071145110039161-15, DOI 10.1017/S00071145110039161-15]
   Baird J, 2005, BMJ-BRIT MED J, V331, P929, DOI 10.1136/bmj.38586.411273.E0
   Barker D, 2003, BRIT MED J, V327, P1428, DOI 10.1136/bmj.327.7429.1428
   BARKER DJP, 1993, DIABETOLOGIA, V36, P62, DOI 10.1007/BF00399095
   BARKER DJP, 1989, LANCET, V2, P577
   BARKER DJP, 1995, MOL MED TODAY, V1, P418, DOI 10.1016/S1357-4310(95)90793-9
   BARKER DJP, 1990, BMJ-BRIT MED J, V301, P259, DOI 10.1136/bmj.301.6746.259
   Bayol SA, 2008, J PHYSIOL-LONDON, V586, P3219, DOI 10.1113/jphysiol.2008.153817
   Bayol SA, 2007, BRIT J NUTR, V98, P843, DOI 10.1017/S0007114507812037
   BEACH RS, 1982, SCIENCE, V218, P469, DOI 10.1126/science.7123244
   Bennis-Taleb N, 1999, J NUTR, V129, P1613, DOI 10.1093/jn/129.8.1613
   Bogdarina I, 2004, LIFE SCI, V74, P1407, DOI 10.1016/j.lfs.2003.08.017
   Bogdarina I, 2007, CIRC RES, V100, P520, DOI 10.1161/01.RES.0000258855.60637.58
   COHEN MP, 1988, DIABETES, V37, P824, DOI 10.2337/diabetes.37.6.824
   DEPRINS FA, 1982, BIOL NEONATE, V41, P16
   Dodic M, 2002, HYPERTENSION, V40, P729, DOI 10.1161/01.HYP.0000036455.62159.7E
   Dolinoy DC, 2007, REPROD TOXICOL, V23, P297, DOI 10.1016/j.reprotox.2006.08.012
   Edwards CRW, 1996, STEROIDS, V61, P263, DOI 10.1016/0039-128X(96)00033-5
   Ellen Roy., 1996, Redefining Nature: Ecology, Culture and Domestication, P1
   Engeham SF, 2010, BRIT J NUTR, V103, P996, DOI 10.1017/S0007114509992662
   Eriksson JG, 2002, DIABETES, V51, P2321, DOI 10.2337/diabetes.51.7.2321
   Forsén T, 1999, BRIT MED J, V319, P1403, DOI 10.1136/bmj.319.7222.1403
   Gambling L, 2004, P NUTR SOC, V63, P553, DOI 10.1079/PNS2004385
   Gambling L, 2002, BIOL REPROD, V66, P516, DOI 10.1095/biolreprod66.2.516
   Gambling L, 2003, J PHYSIOL-LONDON, V552, P603, DOI 10.1113/jphysiol.2003.051383
   Gambling L, 2001, BIOCHEM J, V356, P883, DOI 10.1042/0264-6021:3560883
   Gardner DS, 1997, HYPERTENSION, V30, P1525, DOI 10.1161/01.HYP.30.6.1525
   Gardner DS, 2004, HYPERTENSION, V43, P1290, DOI 10.1161/01.HYP.0000126991.67203.7b
   Gilbert JS, 2005, J PHYSIOL-LONDON, V565, P137, DOI 10.1113/jphysiol.2005.084202
   Gluckman PD, 2005, BIOL NEONATE, V87, P127, DOI 10.1159/000082311
   Gluckman PD, 2004, SCIENCE, V305, P1733, DOI 10.1126/science.1095292
   Gopalakrishnan GS, 2005, BRIT J NUTR, V94, P938, DOI 10.1079/BJN20051559
   HALES CN, 1991, BMJ-BRIT MED J, V303, P1019, DOI 10.1136/bmj.303.6809.1019
   Hales CN, 2001, BRIT MED BULL, V60, P5, DOI 10.1093/bmb/60.1.5
   Harrison M, 2009, BRIT J NUTR, V101, P1020, DOI 10.1017/S0007114508057607
   Hemachandra AH, 2006, INT J EPIDEMIOL, V35, P871, DOI 10.1093/ije/dyl080
   Jansson T, 1999, J HYPERTENS, V17, P1239, DOI 10.1097/00004872-199917090-00002
   Joles JA, J DOHAD, V1, P75
   Kawamura M, 2007, ENDOCRINOLOGY, V148, P1218, DOI 10.1210/en.2006-0706
   Keller G, 2003, NEW ENGL J MED, V348, P101, DOI 10.1056/NEJMoa020549
   Khan IY, 2005, AM J PHYSIOL-REG I, V288, pR127, DOI 10.1152/ajpregu.00354.2004
   Kind KL, 2002, EXP PHYSIOL, V87, P469, DOI 10.1111/j.1469-445X.2002.tb00060.x
   Koupilová I, 1999, J HYPERTENS, V17, P19, DOI 10.1097/00004872-199917010-00004
   Kwon TH, 2003, AM J PHYSIOL-RENAL, V285, pF152, DOI 10.1152/ajprenal.00307.2002
   Langley-Evans SC, 2006, ADV EXP MED BIOL, V573, P87
   Langley-Evans SC, 1999, BIOCHEM SOC T, V27, P88, DOI 10.1042/bst0270088
   Langley-Evans SC, 1999, LIFE SCI, V64, P965, DOI 10.1016/S0024-3205(99)00022-3
   LangleyEvans SC, 1997, J HYPERTENS, V15, P537, DOI 10.1097/00004872-199715050-00010
   LangleyEvans SC, 1996, J NUTR, V126, P1578, DOI 10.1093/jn/126.6.1578
   LangleyEvans SC, 1996, PLACENTA, V17, P169, DOI 10.1016/S0143-4004(96)80010-5
   LangleyEvans SC, 1997, CLIN SCI, V93, P423, DOI 10.1042/cs0930423
   Levitt NS, 1996, NEUROENDOCRINOLOGY, V64, P412, DOI 10.1159/000127146
   Lewis RM, 2001, PLACENTA, V22, P534, DOI 10.1053/plac.2001.0679
   Lillycrop KA, 2005, J NUTR, V135, P1382, DOI 10.1093/jn/135.6.1382
   Lillycrop KA, 2008, BRIT J NUTR, V100, P278, DOI 10.1017/S0007114507894438
   Lillycrop KA, 2007, BRIT J NUTR, V97, P1064, DOI 10.1017/S000711450769196X
   Mallinson JE, 2007, BRIT J NUTR, V98, P292, DOI 10.1017/S0007114507701678
   Matthews SG, 2002, ENDOCR RES, V28, P709, DOI 10.1081/ERC-120016991
   McArdle HJ, 2006, PLACENTA, V27, pS56, DOI 10.1016/j.placenta.2006.01.014
   McMillen IC, 2005, PHYSIOL REV, V85, P571, DOI 10.1152/physrev.00053.2003
   McMullen S, 2005, AM J PHYSIOL-REG I, V288, pR85, DOI 10.1152/ajpregu.00435.2004
   McMullen S, 2005, HYPERTENSION, V46, P1374, DOI 10.1161/01.HYP.0000188702.96256.46
   Meigs JB, 2002, AM J MANAG CARE, V8, pS283
   Monteiro POA, 2005, OBES REV, V6, P143, DOI 10.1111/j.1467-789X.2005.00183.x
   Morgan HD, 2005, HUM MOL GENET, V14, pR47, DOI 10.1093/hmg/ddi114
   Ortiz LA, 2003, HYPERTENSION, V41, P328, DOI 10.1161/01.HYP.0000049763.51269.51
   Pasquali R, 2006, ANN NY ACAD SCI, V1083, P111, DOI 10.1196/annals.1367.009
   PHILLIPS DIW, 1994, DIABETOLOGIA, V37, P150, DOI 10.1007/s001250050086
   Plagemann A, 2000, J NUTR, V130, P2582, DOI 10.1093/jn/130.10.2582
   Risnes KR, 2009, AM J EPIDEMIOL, V170, P622, DOI 10.1093/aje/kwp182
   Salafia CM, 2006, CLIN OBSTET GYNECOL, V49, P236, DOI 10.1097/00003081-200606000-00007
   Samuelsson AM, 2010, HYPERTENSION, V55, P76, DOI 10.1161/HYPERTENSIONAHA.109.139402
   Sherman RC, 2000, CLIN SCI, V98, P269, DOI 10.1042/CS19990275
   Sherman RC, 1998, CLIN SCI, V94, P373, DOI 10.1042/cs0940373
   Simmons RA, 2001, DIABETES, V50, P2279, DOI 10.2337/diabetes.50.10.2279
   SNOECK A, 1990, BIOL NEONATE, V57, P107, DOI 10.1159/000243170
   Stettler N, 2002, PEDIATRICS, V109, P194, DOI 10.1542/peds.109.2.194
   Torrens C, 2009, BRIT J NUTR, V101, P27, DOI 10.1017/S0007114508988760
   Vehaskari VM, 2001, KIDNEY INT, V59, P238, DOI 10.1046/j.1523-1755.2001.00484.x
   Vickers MH, 2000, AM J PHYSIOL-ENDOC M, V279, pE83
   Waterland RA, 2007, ANNU REV NUTR, V27, P363, DOI 10.1146/annurev.nutr.27.061406.093705
   Weaver ICG, 2004, NAT NEUROSCI, V7, P847, DOI 10.1038/nn1276
   Wells JCK, 2009, P NUTR SOC, V68, P179, DOI 10.1017/S0029665109001086
   Woodall SM, 1996, PEDIATR RES, V40, P438, DOI 10.1203/00006450-199609000-00012
   Zung A, 2004, HUM IMMUNOL, V65, P1463, DOI 10.1016/j.humimm.2004.09.006
NR 86
TC 55
Z9 61
U1 0
U2 13
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
J9 MED HYPOTHESES
JI Med. Hypotheses
PD JAN
PY 2012
VL 78
IS 1
BP 88
EP 94
DI 10.1016/j.mehy.2011.09.047
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 881AZ
UT WOS:000299453000022
PM 22047985
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Han, E
   Lee, YH
AF Han, Eugene
   Lee, Yong-ho
TI Non-Alcoholic Fatty Liver Disease: The Emerging Burden in
   Cardiometabolic and Renal Diseases
SO DIABETES & METABOLISM JOURNAL
LA English
DT Review
DE Arrhythmias; cardiac; Atherosclerosis; Diabetes mellitus; Hypertension;
   Insulin resistance; Metabolism; Non-alcoholic fatty liver disease;
   Obesity; Renal insufficiency; Stroke
ID TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   FOLLOW-UP; METABOLIC SYNDROME; RISK-FACTOR; NAFLD; ASSOCIATION; OBESITY;
   DYSLIPIDEMIA
AB As the number of individuals with non-alcoholic fatty liver disease (NAFLD) has increased, the influence of NAFLD on other metabolic diseases has been highlighted. Accumulating epidemiologic evidence indicates that NAFLD not only affects the liver but also increases the risk of extra-hepatic diseases such as type 2 diabetes mellitus, metabolic syndrome, dyslipidemia, hypertension, cardiovascular or cerebrovascular diseases, and chronic kidney disease. Non-alcoholic steatohepatitis, an advanced type of NAFLD, can aggravate these inter-organ relationships and lead to poorer outcomes. NAFLD induces insulin resistance and exacerbates systemic chronic inflammation and oxidative stress, which leads to organ dysfunction in extra-hepatic tissues. Although more research is needed to identify the pathophysiological mechanisms and causal relationship between NAFLD and cardiometabolic and renal diseases, screening for heart, brain, and kidney diseases, risk assessment for diabetes, and a multidisciplinary approach for managing these patients should be highly encouraged.
C1 [Han, Eugene] Keimyung Univ, Div Endocrinol & Metab, Dept Internal Med, Sch Med, Daegu, South Korea.
   [Han, Eugene; Lee, Yong-ho] Yonsei Univ, Grad Sch, Coll Med, Seoul, South Korea.
   [Lee, Yong-ho] Yonsei Univ, Div Endocrinol & Metab, Dept Internal Med, Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea.
C3 Keimyung University; Yonsei University; Yonsei University Health System;
   Yonsei University; Yonsei University Health System
RP Lee, YH (corresponding author), Yonsei Univ, Div Endocrinol & Metab, Dept Internal Med, Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea.
EM yholee@yuhs.ac
RI Lee, Yong-ho/AAT-4106-2020
OI Lee, Yong-ho/0000-0002-6219-4942
FU Korea Healthcare Technology R&D Project, Ministry of Health and Welfare,
   Republic of Korea [HI17C0913]
FX This research was supported by the grant from the Korea Healthcare
   Technology R&D Project, Ministry of Health and Welfare, Republic of
   Korea (HI17C0913).
CR Abdeldyem SM, 2017, J CLIN LIPIDOL, V11, P915, DOI 10.1016/j.jacl.2017.04.115
   Adams LA, 2005, GASTROENTEROLOGY, V129, P113, DOI 10.1053/j.gastro.2005.04.014
   Adams LA, 2017, GUT, V66, P1138, DOI 10.1136/gutjnl-2017-313884
   Adams LA, 2009, AM J GASTROENTEROL, V104, P861, DOI 10.1038/ajg.2009.67
   Bae JC, 2011, DIABETES CARE, V34, P727, DOI 10.2337/dc10-1991
   Bril F, 2016, J CLIN ENDOCR METAB, V101, P644, DOI 10.1210/jc.2015-3111
   Chalasani N, 2012, HEPATOLOGY, V55, P2005, DOI 10.1002/hep.25762
   Chang Y, 2013, AM J GASTROENTEROL, V108, P1861, DOI 10.1038/ajg.2013.349
   Chatrath H, 2012, SEMIN LIVER DIS, V32, P22, DOI 10.1055/s-0032-1306423
   Corey KE, 2015, ALIMENT PHARM THER, V41, P301, DOI 10.1111/apt.13035
   EASL, 2016, OBESITY FACTS, V9, P65, DOI [10.1159/000443344, 10.1007/s00125-016-3902-y, 10.1016/j.jhep.2015.11.004]
   Ekstedt M, 2006, HEPATOLOGY, V44, P865, DOI 10.1002/hep.21327
   Fan JG, 2017, J HEPATOL, V67, P862, DOI 10.1016/j.jhep.2017.06.003
   Farrell GC, 2013, NAT REV GASTRO HEPAT, V10, P307, DOI 10.1038/nrgastro.2013.34
   Goland S, 2006, J CLIN GASTROENTEROL, V40, P949, DOI 10.1097/01.mcg.0000225668.53673.e6
   Goldberg D, 2017, GASTROENTEROLOGY, V152, P1090, DOI 10.1053/j.gastro.2017.01.003
   Hallsworth K, 2013, J HEPATOL, V58, P757, DOI 10.1016/j.jhep.2012.11.015
   Huh JH, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0143560
   Hung CS, 2015, J AM HEART ASSOC, V4, DOI 10.1161/JAHA.115.001820
   Käräjämäki AJ, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0142937
   Kim D, 2013, HEPATOLOGY, V57, P1357, DOI 10.1002/hep.26156
   Kim J, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0180118
   Kim SU, 2017, ATHEROSCLEROSIS, V260, P156, DOI 10.1016/j.atherosclerosis.2017.02.005
   Lee JI, 2016, ENDOCRINOL METAB, V31, P86, DOI 10.3803/EnM.2016.31.1.86
   Lee MK, 2015, ENDOCRINOL METAB, V30, P522, DOI 10.3803/EnM.2015.30.4.522
   Lee YH, 2016, HEPATOLOGY, V63, P776, DOI 10.1002/hep.28376
   Lee YH, 2015, J HEPATOL, V63, P486, DOI 10.1016/j.jhep.2015.02.051
   Lee YH, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0107584
   Leung C, 2016, NAT REV GASTRO HEPAT, V13, P412, DOI 10.1038/nrgastro.2016.85
   López-Suárez A, 2011, EUR J GASTROEN HEPAT, V23, P1011, DOI 10.1097/MEG.0b013e32834b8d52
   Loria P, 2008, CLIN SCI, V115, P1, DOI 10.1042/CS20070311
   Luna-Luna M, 2015, ARCH MED RES, V46, P392, DOI 10.1016/j.arcmed.2015.05.007
   Mantovani A, 2016, DIABETES CARE, V39, P1416, DOI 10.2337/dc16-0091
   Musso G, 2014, PLOS MED, V11, DOI 10.1371/journal.pmed.1001680
   Nseir W, 2011, DIGEST DIS SCI, V56, P3439, DOI 10.1007/s10620-011-1767-y
   Oh SW, 2011, DIABETES METAB J, V35, P561, DOI 10.4093/dmj.2011.35.6.561
   Pais R, 2017, ALIMENT PHARM THER, V46, P856, DOI 10.1111/apt.14261
   Park SK, 2013, HEPATOLOGY, V57, P1378, DOI 10.1002/hep.26183
   Perseghin G, 2008, HEPATOLOGY, V47, P51, DOI 10.1002/hep.21983
   Peterson LR, 2004, CIRCULATION, V109, P2191, DOI 10.1161/01.CIR.0000127959.28627.F8
   Rijzewijk LJ, 2010, J AM COLL CARDIOL, V56, P225, DOI 10.1016/j.jacc.2010.02.049
   Rinella ME, 2015, JAMA-J AM MED ASSOC, V313, P2263, DOI 10.1001/jama.2015.5370
   Ryoo JH, 2014, J GASTROEN HEPATOL, V29, P1926, DOI 10.1111/jgh.12643
   Sinn DH, 2017, GUT, V66, P323, DOI 10.1136/gutjnl-2016-311854
   Sung KC, 2014, J HEPATOL, V60, P1040, DOI 10.1016/j.jhep.2014.01.009
   Tahara N, 2012, DIABETES CARE, V35, P2618, DOI 10.2337/dc12-0087
   Tang WHW, 2013, NEW ENGL J MED, V368, P1575, DOI 10.1056/NEJMoa1109400
   Targher G, 2006, DIABETES CARE, V29, P1325, DOI 10.2337/dc06-0135
   Targher G, 2017, NAT REV NEPHROL, V13, P297, DOI 10.1038/nrneph.2017.16
   Targher G, 2016, J HEPATOL, V65, P589, DOI 10.1016/j.jhep.2016.05.013
   Targher G, 2010, CLIN J AM SOC NEPHRO, V5, P2166, DOI 10.2215/CJN.05050610
   Targher G, 2010, NEW ENGL J MED, V363, P1341, DOI 10.1056/NEJMra0912063
   Villanova N, 2005, HEPATOLOGY, V42, P473, DOI 10.1002/hep.20781
   Yamada T, 2010, J GASTROEN HEPATOL, V25, P352, DOI 10.1111/j.1440-1746.2009.05998.x
   Yilmaz Y, 2010, METABOLISM, V59, P1327, DOI 10.1016/j.metabol.2009.12.012
   Ying I, 2011, EPIDEMIOLOGY, V22, P129, DOI 10.1097/EDE.0b013e3181feb50a
   Yoon KH, 2006, LANCET, V368, P1681, DOI 10.1016/S0140-6736(06)69703-1
   Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431
   Younossi ZM, 2011, CLIN GASTROENTEROL H, V9, P524, DOI 10.1016/j.cgh.2011.03.020
   Zhang QQ, 2015, J CLIN TRANSL HEPATO, V3, P78, DOI 10.14218/JCTH.2014.00037
NR 60
TC 61
Z9 65
U1 0
U2 5
PU KOREAN DIABETES ASSOC
PI SEOUL
PA 101-2104, LOTTE CASTLE PRES, 109 MAPO-DAERO, MAPO-GU, SEOUL, 04146,
   SOUTH KOREA
SN 2233-6079
EI 2233-6087
J9 DIABETES METAB J
JI Diabetes Metab. J.
PD DEC
PY 2017
VL 41
IS 6
BP 430
EP 437
DI 10.4093/dmj.2017.41.6.430
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FR0PP
UT WOS:000418765500002
PM 29199410
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Murphy, AJ
   Kraakman, MJ
   Kammoun, HL
   Dragoljevic, D
   Lee, MKS
   Lawlor, KE
   Wentworth, JM
   Vasanthakumar, A
   Gerlic, M
   Whitehead, LW
   DiRago, L
   Cengia, L
   Lane, RM
   Metcalf, D
   Vince, JE
   Harrison, LC
   Kallies, A
   Kile, BT
   Croker, BA
   Febbraio, MA
   Masters, SL
AF Murphy, Andrew J.
   Kraakman, Michael J.
   Kammoun, Helene L.
   Dragoljevic, Dragana
   Lee, Man K. S.
   Lawlor, Kate E.
   Wentworth, John M.
   Vasanthakumar, Ajithkumar
   Gerlic, Motti
   Whitehead, Lachlan W.
   DiRago, Ladina
   Cengia, Louise
   Lane, Rachael M.
   Metcalf, Donald
   Vince, James E.
   Harrison, Leonard C.
   Kallies, Axel
   Kile, Benjamin T.
   Croker, Ben A.
   Febbraio, Mark A.
   Masters, Seth L.
TI IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and
   Metabolic Syndrome
SO CELL METABOLISM
LA English
DT Article
ID TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE; WEIGHT-LOSS;
   ADIPOSE-TISSUE; INTERLEUKIN-18; ACTIVATION; MICE; ADIPONECTIN; CELLS
AB Interleukin-18 (IL-18) is activated by Caspase-1 in inflammasome complexes and has anti-obesity effects; however, it is not known which inflammasome regulates this process. We found that mice lacking the NLRP1 inflammasome phenocopy mice lacking IL-18, with spontaneous obesity due to intrinsic lipid accumulation. This is exacerbated when the mice are fed a high-fat diet (HFD) or a high-protein diet, but not when mice are fed a HFD with low energy density (high fiber). Furthermore, mice with an activating mutation in NLRP1, and hence increased IL-18, have decreased adiposity and are resistant to diet-induced metabolic dysfunction. Feeding these mice a HFD further increased plasma IL-18 concentrations and strikingly resulted in loss of adipose tissue mass and fatal cachexia, which could be prevented by genetic deletion of IL-18. Thus, NLRP1 is an innate immune sensor that functions in the context of metabolic stress to produce IL-18, preventing obesity and metabolic syndrome.
C1 [Murphy, Andrew J.; Kraakman, Michael J.; Kammoun, Helene L.; Dragoljevic, Dragana; Lee, Man K. S.] Baker IDI Heart & Diabet Inst, Haematopoiesis & Leukocyte Biol, Melbourne, Vic 3004, Australia.
   [Kammoun, Helene L.; Febbraio, Mark A.] Baker IDI Heart & Diabet Inst, Cellular & Mol Metab Lab, Melbourne, Vic 3004, Australia.
   [Murphy, Andrew J.; Dragoljevic, Dragana; Lee, Man K. S.] Monash Univ, Dept Immunol, Melbourne, Vic 3004, Australia.
   [Lawlor, Kate E.; Vince, James E.; Masters, Seth L.] Walter & Eliza Hall Inst Med Res, Div Inflammat, Parkville, Vic 3052, Australia.
   [Wentworth, John M.; Harrison, Leonard C.] Walter & Eliza Hall Inst Med Res, Div Mol Med, Parkville, Vic 3052, Australia.
   [Vasanthakumar, Ajithkumar; Kallies, Axel] Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3052, Australia.
   [Lane, Rachael M.; Kile, Benjamin T.] Walter & Eliza Hall Inst Med Res, Div ACRF Chem Biol, Parkville, Vic 3052, Australia.
   [DiRago, Ladina; Cengia, Louise; Metcalf, Donald] Walter & Eliza Hall Inst Med Res, Div Canc & Hematol, Parkville, Vic 3052, Australia.
   [Whitehead, Lachlan W.] Walter & Eliza Hall Inst Med Res, Div Syst Biol & Personalised Med, Parkville, Vic 3052, Australia.
   [Lawlor, Kate E.; Wentworth, John M.; Vasanthakumar, Ajithkumar; Metcalf, Donald; Vince, James E.; Harrison, Leonard C.; Kallies, Axel; Kile, Benjamin T.; Masters, Seth L.] Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia.
   [Gerlic, Motti] Tel Aviv Univ, Sackler Fac Med, Dept Clin Microbiol & Immunol, IL-69978 Tel Aviv, Israel.
   [Croker, Ben A.] Harvard Univ, Sch Med, Boston Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA.
   [Febbraio, Mark A.] St Vincents Hosp, Garvan Inst Med Res, Div Diabet & Metab, Darlinghurst, NSW 2010, Australia.
C3 Baker Heart and Diabetes Institute; Baker Heart and Diabetes Institute;
   Monash University; Walter & Eliza Hall Institute; Walter & Eliza Hall
   Institute; Walter & Eliza Hall Institute; Walter & Eliza Hall Institute;
   Walter & Eliza Hall Institute; Walter & Eliza Hall Institute; University
   of Melbourne; Tel Aviv University; Sackler Faculty of Medicine; Harvard
   University; Harvard University Medical Affiliates; Boston Children's
   Hospital; Harvard Medical School; Garvan Institute of Medical Research;
   NSW Health; St Vincents Hospital Sydney
RP Masters, SL (corresponding author), Walter & Eliza Hall Inst Med Res, Div Inflammat, Parkville, Vic 3052, Australia.; Masters, SL (corresponding author), Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia.
EM masters@wehi.edu.au
RI Febbraio, Mark/AAE-9632-2019; Dragoljevic, Dragana/JFK-2013-2023;
   Masters, Seth/LXA-3881-2024; Kile, Benjamin/F-6593-2011; gerlic,
   mordechay/U-3484-2017; masters, seth/N-2886-2013
OI Kile, Benjamin/0000-0002-8836-8947; gerlic,
   mordechay/0000-0001-9518-1833; masters, seth/0000-0003-4763-576X;
   Lawlor, Kate/0000-0003-0471-6842; Murphy, Andrew/0000-0001-7039-7777;
   VASANTHAKUMAR, AJITHKUMAR/0000-0002-1620-7781; Kallies,
   Axel/0000-0002-6312-6968; Febbraio, Mark/0000-0002-9296-4418; Kraakman,
   Michael/0000-0002-5755-0447; Wentworth, John/0000-0002-5197-3529;
   Croker, Ben/0000-0002-0885-3599
FU Australian National Health and Medical Research Council (NHMRC)
   [361646]; Australian Phenomics Network; Australian Cancer Research
   Foundation; Victorian State Government Operational Infrastructure
   Support Grant; National Heart Foundation; Diabetes Australia Research
   Trust Australia;  [637367];  [1002426];  [1051210];  [1057815]; 
   [461219];  [363652];  [1016647]
FX We thank L. Scott, R. Crawley, and K. Hay for outstanding animal
   husbandry. We also thank Prof A. Roberts (The Walter and Eliza Hall
   Institute) for assistance with mouse studies. This work was supported by
   Project Grants (637367, 1002426, 1051210, 1057815), Program Grants
   (461219, 363652, 1016647), Fellowships (S.L.M., B.T.K., M.A.F., A.J.M.,
   J.E.V.), and an Independent Research Institutes Infrastructure Support
   Scheme Grant (361646) from the Australian National Health and Medical
   Research Council (NHMRC); the Australian Phenomics Network, the
   Australian Cancer Research Foundation, and a Victorian State Government
   Operational Infrastructure Support Grant. A.J.M was also supported by a
   future leader fellowship from the National Heart Foundation, and a
   Viertel award from Diabetes Australia Research Trust Australia.
CR Boyden ED, 2006, NAT GENET, V38, P240, DOI 10.1038/ng1724
   Esposito K, 2003, AM J CLIN NUTR, V78, P1135, DOI 10.1093/ajcn/78.6.1135
   Fain JN, 2006, METABOLISM, V55, P1113, DOI 10.1016/j.metabol.2006.04.008
   Febbraio MA, 2014, TRENDS ENDOCRIN MET, V25, P312, DOI 10.1016/j.tem.2014.02.004
   Fischer CP, 2005, CLIN IMMUNOL, V117, P152, DOI 10.1016/j.clim.2005.07.008
   Gorfu G, 2014, MBIO, V5, DOI 10.1128/mBio.01117-13
   Henao-Mejia J, 2012, NATURE, V482, P179, DOI 10.1038/nature10809
   Hung J, 2005, ARTERIOSCL THROM VAS, V25, P1268, DOI 10.1161/01.ATV.0000163843.70369.12
   Jitprasertwong P, 2014, CYTOKINE, V65, P222, DOI 10.1016/j.cyto.2013.10.008
   Kelley DE, 2001, DIABETES CARE, V24, P933, DOI 10.2337/diacare.24.5.933
   Kraakman MJ, 2015, CELL METAB, V21, P403, DOI 10.1016/j.cmet.2015.02.006
   Labow M, 1997, J IMMUNOL, V159, P2452
   Liao KC, 2013, INFECT IMMUN, V81, P570, DOI 10.1128/IAI.01003-12
   Lindegaard B, 2013, DIABETES, V62, P3064, DOI 10.2337/db12-1095
   Masters SL, 2012, IMMUNITY, V37, P1009, DOI 10.1016/j.immuni.2012.08.027
   Myers MG, 2010, TRENDS ENDOCRIN MET, V21, P643, DOI 10.1016/j.tem.2010.08.002
   Netea MG, 2006, NAT MED, V12, P650, DOI 10.1038/nm1415
   Schernthaner GH, 2006, OBES SURG, V16, P709, DOI 10.1381/096089206777346763
   Tajik N, 2013, J ENDOCRINOL INVEST, V36, P211, DOI 10.3275/8465
   Takeda K, 1998, IMMUNITY, V8, P383, DOI 10.1016/S1074-7613(00)80543-9
   Troseid M, 2009, METABOLISM, V58, P1543, DOI 10.1016/j.metabol.2009.04.031
   Vandanmagsar B, 2011, NAT MED, V17, P179, DOI 10.1038/nm.2279
   Vilarrasa N, 2007, CLIN ENDOCRINOL, V67, P679, DOI 10.1111/j.1365-2265.2007.02945.x
   Wen HT, 2011, NAT IMMUNOL, V12, P408, DOI 10.1038/ni.2022
   Westwell-Roper Clara, 2013, Methods Mol Biol, V1040, P9, DOI 10.1007/978-1-62703-523-1_2
   Witola WH, 2011, INFECT IMMUN, V79, P756, DOI 10.1128/IAI.00898-10
   Zilverschoon GRC, 2008, INT J OBESITY, V32, P1407, DOI 10.1038/ijo.2008.109
   Zorriila EP, 2007, P NATL ACAD SCI USA, V104, P11097, DOI 10.1073/pnas.0611523104
NR 28
TC 143
Z9 150
U1 0
U2 16
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD JAN 12
PY 2016
VL 23
IS 1
BP 155
EP 164
DI 10.1016/j.cmet.2015.09.024
PG 10
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA DI6MO
UT WOS:000373613400017
PM 26603191
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Kelsall, HL
   McKenzie, DP
   Sim, MR
   Leder, K
   Forbes, AB
   Dwyer, T
AF Kelsall, Helen L.
   McKenzie, Dean P.
   Sim, Malcolm R.
   Leder, Karin
   Forbes, Andrew B.
   Dwyer, Terence
TI Physical, Psychological, and Functional Comorbidities of Multisymptom
   Illness in Australian Male Veterans of the 1991 Gulf War
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE comorbidity; fatigue; Gulf War; psychology; quality of life; veterans
ID POSTTRAUMATIC-STRESS-DISORDER; METABOLIC SYNDROME; HEALTH-STATUS;
   SYMPTOMS; RISK; ASSOCIATION; DISTRESS
AB Multisymptom illness is more prevalent in 1991 Gulf War veterans than in military comparison groups; less is known about comorbidities. The authors compared physical, psychological, and functional comorbidities in Australian male Gulf War I veterans with those in actively (non-Gulf) deployed and nondeployed military personnel by using a questionnaire and medical assessment in 2000-2002. Multisymptom illness was more common in male Gulf War veterans than in the comparison group (odds ratio (OR) = 1.80, 95% confidence interval (CI): 1.48, 2.19). Stratifying by deployment status in the comparison group made little difference in this association. Gulf War veterans with multisymptom illness had increased psychiatric disorders, including major depression (OR = 6.31, 95% CI: 4.19, 9.52) and posttraumatic stress disorder (OR = 9.77, 95% CI: 5.39, 18.59); increased unexplained chronic fatigue (OR = 13.32, 95% CI: 7.70, 23.05); and more reported functional impairment and poorer quality of life, but objective physical and laboratory outcomes were similar to those for veterans without multisymptom illness. Similar patterns were found in the comparison groups; differences across the 3 groups were statistically significant for only hospitalization, obstructive liver disease, and Epstein-Barr virus exposure. Multisymptom illness is more prevalent in Gulf War I veterans, but the pattern of comorbidities is similar for actively deployed and nondeployed military personnel.
C1 [Kelsall, Helen L.; McKenzie, Dean P.; Sim, Malcolm R.; Leder, Karin; Forbes, Andrew B.] Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic 3004, Australia.
   [Kelsall, Helen L.] Canc Council Victoria, Canc Epidemiol Ctr, Carlton, Vic, Australia.
   [Dwyer, Terence] Royal Childrens Hosp, Murdoch Childrens Res Inst, Parkville, Vic 3052, Australia.
C3 Monash University; Cancer Council Victoria; Royal Children's Hospital
   Melbourne; Murdoch Children's Research Institute
RP Kelsall, HL (corresponding author), Monash Univ, Alfred Hosp, Monash Ctr Occupat & Environm Hlth, Dept Epidemiol & Prevent Med, Melbourne, Vic 3004, Australia.
EM helen.kelsall@med.monash.edu.au
RI Leder, Karin/AAD-2388-2019; Sim, Malcolm/I-2761-2014
OI Kelsall, Helen/0000-0003-0664-3376; Leder, Karin/0000-0003-1368-1039;
   Sim, Malcolm/0000-0003-4739-2817; Forbes, Andrew/0000-0003-4269-914X
FU National Health and Medical Research Foundation Public Health
   Postdoctoral Fellowship [384354, 465363]; Australian Government
   Department of Veterans' Affairs
FX This work was supported by a National Health and Medical Research
   Foundation Public Health Postdoctoral Fellowship (grant 384354 to H. K.)
   and a PhD scholarship (grant 465363 to D. M). The Australian Gulf War
   Veterans' Health Study was supported by the Australian Government
   Department of Veterans' Affairs.
CR [Anonymous], 1995, AM J RESP CRIT CARE, V152, P1107, DOI 10.1164/ajrccm.152.3.7663792
   [Anonymous], 2003, Robust Regression and Outlier Detection
   [Anonymous], LOGXACT 7 WIND
   [Anonymous], STAT STAT SOFTW VERS
   [Anonymous], 2005, IDF CONS WORLDW DEF
   [Anonymous], HLTH STUD CAN FORC P
   [Anonymous], 1998, National Nutrition Survey Users' Guide 1995
   [Anonymous], QRS SPIROCARD QRS SP
   [Anonymous], MMWR-MORBID MORTAL W
   [Anonymous], COMP INT DIAGN INT C
   Babor T., 1989, ALCOHOL USE DISORDER
   Barrett DH, 2002, PSYCHOSOMATICS, V43, P195, DOI 10.1176/appi.psy.43.3.195
   Black HR, 1997, ARCH INTERN MED, V157, P2413
   Blanchard MS, 2006, AM J EPIDEMIOL, V163, P66, DOI 10.1093/aje/kwj008
   Cherry N, 2001, OCCUP ENVIRON MED, V58, P291, DOI 10.1136/oem.58.5.291
   Engel CC, 2000, PSYCHOSOM MED, V62, P739, DOI 10.1097/00006842-200011000-00001
   Engel CC, 2002, AM J PSYCHIAT, V159, P998, DOI 10.1176/appi.ajp.159.6.998
   Forbes AB, 2004, OCCUP ENVIRON MED, V61, P1014, DOI 10.1136/oem.2003.011791
   Fukuda K, 1998, JAMA-J AM MED ASSOC, V280, P981, DOI 10.1001/jama.280.11.981
   Goldbacher EM, 2007, ANN BEHAV MED, V34, P240, DOI 10.1007/BF02874549
   Goldberg D. P., 1972, The detection of psychiatric illness by questionnaire
   Heppner PS, 2009, BMC MED, V7, DOI 10.1186/1741-7015-7-1
   Hotopf M, 2003, BRIT MED J, V327, P1370, DOI 10.1136/bmj.327.7428.1370
   Ikin JF, 2004, BRIT J PSYCHIAT, V185, P116, DOI 10.1192/bjp.185.2.116
   Ismail K, 2006, PHILOS T R SOC B, V361, P543, DOI 10.1098/rstb.2006.1815
   Kang HK, 2009, J OCCUP ENVIRON MED, V51, P401, DOI 10.1097/JOM.0b013e3181a2feeb
   Kang HK, 2000, J OCCUP ENVIRON MED, V42, P491, DOI 10.1097/00043764-200005000-00006
   Keller A, 2006, J NERV MENT DIS, V194, P188, DOI 10.1097/01.nmd.0000202494.75723.83
   Kelsall H, 2005, INT J EPIDEMIOL, V34, P810, DOI 10.1093/ije/dyi084
   Kelsall H, 2006, J PSYCHOSOM RES, V60, P575, DOI 10.1016/j.jpsychores.2006.04.002
   Kelsall HL, 2004, OCCUP ENVIRON MED, V61, P1006, DOI 10.1136/oem.2003.009258
   Kelsall HL, 2004, THORAX, V59, P897, DOI 10.1136/thx.2003.017103
   Kroenke K, 1994, Arch Fam Med, V3, P774
   Kupchik M, 2007, DEPRESS ANXIETY, V24, P244, DOI 10.1002/da.20189
   Lemeshow S, 2000, Applied logistic regression, VSecond, DOI 10.1002/0471722146
   Long J.S., 2007, Regression models for categorical dependent variables using Stata
   McArdle W., 1986, EXERCISE PHYSL ENERG
   McCullagh P., 2019, GEN LINEAR MODELS, DOI DOI 10.1201/9780203753736
   McKenzie DP, 2006, ADDICT BEHAV, V31, P1683, DOI 10.1016/j.addbeh.2005.12.027
   McKenzie DP, 2004, PSYCHOL MED, V34, P1419, DOI 10.1017/S0033291704002818
   MEHTA CR, 1995, STAT MED, V14, P2143, DOI 10.1002/sim.4780141908
   Mittal VA, 2011, PSYCHIAT RES, V189, P158, DOI 10.1016/j.psychres.2011.06.006
   ROBINS LN, 1988, ARCH GEN PSYCHIAT, V45, P1069
   Salamon R, 2006, INT J EPIDEMIOL, V35, P479, DOI 10.1093/ije/dyi318
   Schmidt NB, 2004, TAXOMETRICS NEW DIAG
   Schwartz DA, 1997, JAMA-J AM MED ASSOC, V277, P238, DOI 10.1001/jama.277.3.238
   Steele L, 2000, AM J EPIDEMIOL, V152, P992, DOI 10.1093/aje/152.10.992
   Unwin C, 1999, LANCET, V353, P169, DOI 10.1016/S0140-6736(98)11338-7
   Ware JE, 1996, MED CARE, V34, P220, DOI 10.1097/00005650-199603000-00003
   Witteveen AB, 2007, J NERV MENT DIS, V195, P31, DOI 10.1097/01.nmd.0000252010.19753.19
NR 50
TC 34
Z9 37
U1 0
U2 4
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD OCT 15
PY 2009
VL 170
IS 8
BP 1048
EP 1056
DI 10.1093/aje/kwp238
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 502GT
UT WOS:000270445300015
PM 19762370
DA 2025-06-11
ER

PT J
AU Jamshed, H
   Beyl, RA
   Della Manna, DL
   Yang, ES
   Ravussin, E
   Peterson, CM
AF Jamshed, Humaira
   Beyl, Robbie A.
   Della Manna, Deborah L.
   Yang, Eddy S.
   Ravussin, Eric
   Peterson, Courtney M.
TI Early Time-Restricted Feeding Improves 24-Hour Glucose Levels and
   Affects Markers of the Circadian Clock, Aging, and Autophagy in Humans
SO NUTRIENTS
LA English
DT Article
DE intermittent fasting; time-restricted feeding; meal timing; circadian
   rhythms; circadian system
ID INTERMITTENT FASTING MODULATION; REDUCED MEAL FREQUENCY; WEIGHT-LOSS;
   CALORIC-INTAKE; INSULIN-RESISTANCE; DIABETIC SYNDROME; GENE-EXPRESSION;
   ACTIVE PHASE; BODY-FAT; HEALTHY
AB Time-restricted feeding (TRF) is a form of intermittent fasting that involves having a longer daily fasting period. Preliminary studies report that TRF improves cardiometabolic health in rodents and humans. Here, we performed the first study to determine how TRF affects gene expression, circulating hormones, and diurnal patterns in cardiometabolic risk factors in humans. Eleven overweight adults participated in a 4-day randomized crossover study where they ate between 8 am and 2 pm (early TRF (eTRF)) and between 8 am and 8 pm (control schedule). Participants underwent continuous glucose monitoring, and blood was drawn to assess cardiometabolic risk factors, hormones, and gene expression in whole blood cells. Relative to the control schedule, eTRF decreased mean 24-hour glucose levels by 4 +/- 1 mg/dl (p = 0.0003) and glycemic excursions by 12 +/- 3 mg/dl (p = 0.001). In the morning before breakfast, eTRF increased ketones, cholesterol, and the expression of the stress response and aging gene SIRT1 and the autophagy gene LC3A (all p < 0.04), while in the evening, it tended to increase brain-derived neurotropic factor (BNDF; p = 0.10) and also increased the expression of MTOR (p = 0.007), a major nutrient-sensing protein that regulates cell growth. eTRF also altered the diurnal patterns in cortisol and the expression of several circadian clock genes (p < 0.05). eTRF improves 24-hour glucose levels, alters lipid metabolism and circadian clock gene expression, and may also increase autophagy and have anti-aging effects in humans.
C1 [Jamshed, Humaira; Peterson, Courtney M.] Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35294 USA.
   [Beyl, Robbie A.] Pennington Biomed Res Ctr, Biostat & Anal Lab, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
   [Della Manna, Deborah L.; Yang, Eddy S.] Univ Alabama Birmingham, Dept Radiat Oncol, Birmingham, AL 35294 USA.
   [Ravussin, Eric] Pennington Biomed Res Ctr, Translat Physiol Lab, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
C3 University of Alabama System; University of Alabama Birmingham;
   Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center; University of Alabama System;
   University of Alabama Birmingham; Louisiana State University System;
   Louisiana State University; Pennington Biomedical Research Center
RP Peterson, CM (corresponding author), Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35294 USA.
EM humaira.jphd@gmail.com; robbie.beyl@pbrc.edu; dellaman@uab.edu;
   eyang@uab.edu; eric.ravussin@pbrc.edu; cpeterso@uab.edu
RI Jamshed, Humaira/I-4739-2019; Beyl, Robbie/N-1951-2017; Ravussin,
   Eric/N-1985-2017
OI Ravussin, Eric/0000-0003-2129-547X; Jamshed, Humaira/0000-0002-3386-3748
FU Early Career Research Grant from The Obesity Society; NIH's National
   Center for Advancing Translational Sciences [KL2 TR001419]; NIH's
   National Institute of General Medical Sciences [U54 GM104940]; NORC
   Center Grant [P30 DK072476]
FX This research was funded by an Early Career Research Grant from The
   Obesity Society (C.M.P.); career development grants (to C.M.P.) under
   center grants KL2 TR001419 from the NIH's National Center for Advancing
   Translational Sciences and U54 GM104940 from NIH's National Institute of
   General Medical Sciences, which supports the Louisiana Clinical and
   Translational Science Center (LA CaTS); and a NORC Center Grant P30
   DK072476 entitled "Nutritional Programming: Environmental and Molecular
   Interactions" (E.R.). The content is solely the responsibility of the
   authors and does not necessarily represent the official views of the
   National Institutes of Health.
CR Anton SD, 2018, OBESITY, V26, P254, DOI 10.1002/oby.22065
   Antoni R, 2018, J NUTR SCI, V7, DOI 10.1017/jns.2018.13
   Antoni R, 2017, P NUTR SOC, V76, P361, DOI 10.1017/S0029665116002986
   Belkacemi L, 2012, INT J ENDOCRINOL, V2012, DOI 10.1155/2012/962012
   Belkacemi L, 2011, INT J MOL MED, V27, P95, DOI 10.3892/ijmm.2010.556
   Belkacemi L, 2010, INT J MOL MED, V26, P759, DOI 10.3892/ijmm_00000523
   Carlson O, 2007, METABOLISM, V56, P1729, DOI 10.1016/j.metabol.2007.07.018
   Chaix A, 2019, CELL METAB, V29, P303, DOI 10.1016/j.cmet.2018.08.004
   Chaix A, 2014, CELL METAB, V20, P991, DOI 10.1016/j.cmet.2014.11.001
   Choi HR, 2018, NUTRIENTS, V10, DOI 10.3390/nu10121895
   Chung H, 2016, METABOLISM, V65, P1743, DOI 10.1016/j.metabol.2016.09.006
   Cioffi I, 2018, J TRANSL MED, V16, DOI 10.1186/s12967-018-1748-4
   Cote I, 2018, AM J PHYSIOL-REG I, V315, pR751, DOI 10.1152/ajpregu.00076.2018
   Dallmann R, 2012, P NATL ACAD SCI USA, V109, P2625, DOI 10.1073/pnas.1114410109
   Delahaye LB, 2018, APPL PHYSIOL NUTR ME, V43, P1033, DOI 10.1139/apnm-2017-0706
   Duncan MJ, 2016, PHYSIOL BEHAV, V167, P1, DOI 10.1016/j.physbeh.2016.08.027
   Gabel Kelsey, 2018, Nutr Healthy Aging, V4, P345, DOI 10.3233/NHA-170036
   Gamble KL, 2014, NAT REV ENDOCRINOL, V10, P466, DOI 10.1038/nrendo.2014.78
   Garaulet M, 2013, INT J OBESITY, V37, P604, DOI 10.1038/ijo.2012.229
   García-Luna C, 2017, J ENDOCRINOL, V232, P15, DOI 10.1530/JOE-16-0402
   Gasmi M, 2018, NUTRITION, V51-52, P29, DOI 10.1016/j.nut.2017.12.014
   Gill S, 2015, CELL METAB, V22, P789, DOI 10.1016/j.cmet.2015.09.005
   Harvie M, 2017, BEHAV SCI, V7, DOI 10.3390/bs7010004
   Hatori M, 2012, CELL METAB, V15, P848, DOI 10.1016/j.cmet.2012.04.019
   Hibi M, 2013, AM J PHYSIOL-REG I, V304, pR94, DOI 10.1152/ajpregu.00115.2012
   Jakubowicz D, 2017, DIABETES CARE, V40, P1573, DOI 10.2337/dc16-2753
   Jakubowicz D, 2013, OBESITY, V21, P2504, DOI 10.1002/oby.20460
   Kant AK, 2014, AM J CLIN NUTR, V100, P938, DOI 10.3945/ajcn.114.085191
   Keim NL, 1997, J NUTR, V127, P75, DOI 10.1093/jn/127.1.75
   Kudo T, 2004, DIABETOLOGIA, V47, P1425, DOI 10.1007/s00125-004-1461-0
   Li XM, 2010, CANCER RES, V70, P3351, DOI 10.1158/0008-5472.CAN-09-4235
   Longo VD, 2014, CELL METAB, V19, P181, DOI 10.1016/j.cmet.2013.12.008
   Mani K, 2018, COMPR PHYSIOL, V8, P1639, DOI 10.1002/cphy.c180005
   Manzanero S, 2014, J CEREBR BLOOD F MET, V34, P897, DOI 10.1038/jcbfm.2014.36
   Martinez-Lopez N, 2017, CELL METAB, V26, P856, DOI 10.1016/j.cmet.2017.09.020
   Mattson MP, 2017, AGEING RES REV, V39, P46, DOI 10.1016/j.arr.2016.10.005
   Mitchell SJ, 2019, CELL METAB, V29, P221, DOI 10.1016/j.cmet.2018.08.011
   Moro T, 2016, J TRANSL MED, V14, DOI 10.1186/s12967-016-1044-0
   Morris CJ, 2016, P NATL ACAD SCI USA, V113, pE1402, DOI 10.1073/pnas.1516953113
   Morris CJ, 2015, P NATL ACAD SCI USA, V112, pE2225, DOI 10.1073/pnas.1418955112
   Olsen MK, 2017, PHYSIOL BEHAV, V173, P298, DOI 10.1016/j.physbeh.2017.02.032
   Park S, 2017, J NUTR BIOCHEM, V40, P14, DOI 10.1016/j.jnutbio.2016.10.003
   Patterson RE, 2017, ANNU REV NUTR, V37, P371, DOI 10.1146/annurev-nutr-071816-064634
   PHILIPPENS KMH, 1977, J NUTR, V107, P176, DOI 10.1093/jn/107.2.176
   Poggiogalle E, 2018, METABOLISM, V84, P11, DOI 10.1016/j.metabol.2017.11.017
   Rabinovitz HR, 2014, OBESITY, V22, pE46, DOI 10.1002/oby.20654
   Rahman S, 2011, CELL COMMUN SIGNAL, V9, DOI 10.1186/1478-811X-9-11
   Ravussin E., 2019, OBESITY
   Reid KJ, 2014, NUTR RES, V34, P930, DOI 10.1016/j.nutres.2014.09.010
   Ruiz-Lozano T, 2016, CLIN NUTR, V35, P1308, DOI 10.1016/j.clnu.2016.02.007
   Scheer FAJL, 2009, P NATL ACAD SCI USA, V106, P4453, DOI 10.1073/pnas.0808180106
   Seimon RV, 2015, MOL CELL ENDOCRINOL, V418, P153, DOI 10.1016/j.mce.2015.09.014
   Sherman H, 2012, FASEB J, V26, P3493, DOI 10.1096/fj.12-208868
   Sherman H, 2011, J CELL MOL MED, V15, P2745, DOI 10.1111/j.1582-4934.2010.01160.x
   Smith NJG, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020350
   Stote KS, 2007, AM J CLIN NUTR, V85, P981, DOI 10.1093/ajcn/85.4.981
   Sun SM, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0201261
   Sundaram S, 2018, NUTR RES, V59, P72, DOI 10.1016/j.nutres.2018.07.014
   Sundaram S, 2016, NUTR RES, V36, P603, DOI 10.1016/j.nutres.2016.02.005
   Sutton EF, 2018, CELL METAB, V27, P1212, DOI 10.1016/j.cmet.2018.04.010
   Tinsley GM, 2018, FUTUR CARDIOL, V14, P47, DOI 10.2217/fca-2017-0038
   Tinsley GM, 2017, EUR J SPORT SCI, V17, P200, DOI 10.1080/17461391.2016.1223173
   Tsang AH, 2016, J ENDOCRINOL, V230, pR1, DOI 10.1530/JOE-16-0051
   VanCauter E, 1997, ENDOCR REV, V18, P716, DOI 10.1210/er.18.5.716
   Wefers J, 2018, P NATL ACAD SCI USA, V115, P7789, DOI 10.1073/pnas.1722295115
   Woodie LN, 2018, METABOLISM, V82, P1, DOI 10.1016/j.metabol.2017.12.004
   Wu MW, 2004, LIFE SCI, V75, P1181, DOI 10.1016/j.lfs.2004.02.014
   Wu T, 2011, CHRONOBIOL INT, V28, P890, DOI 10.3109/07420528.2011.622599
   Zarrinpar A, 2014, CELL METAB, V20, P1006, DOI 10.1016/j.cmet.2014.11.008
NR 69
TC 430
Z9 470
U1 14
U2 194
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2019
VL 11
IS 6
AR 1234
DI 10.3390/nu11061234
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA II1AJ
UT WOS:000474936700040
PM 31151228
OA gold, Green Published, Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Ha, JH
   Park, S
   Yoon, D
   Kim, B
AF Ha, Jee Hyun
   Park, Soyeon
   Yoon, Daehyun
   Kim, Byungsu
TI Short-term heart rate variability in older patients with newly diagnosed
   depression
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Depression; Heart rate variability; HRV; Autonomic nervous system; Old
   age
ID MAJOR DEPRESSION; METABOLIC SYNDROME; NERVOUS-SYSTEM; DISEASE; RISK;
   MECHANISMS; MORTALITY; DISORDER
AB Dysfunction of the autonomic nervous system has been considered to be a risk factor for major depressive disorder (MDD) and cardiovascular disease (CVD). The aim of this study was to evaluate short-term heart rate variability (HRV) in elderly patients with newly diagnosed MDD. Thirty MDD patients over 60 years old newly diagnosed by a structured interview were enrolled, free from antidepressants. Socio-demographic data, blood tests, and heart rate variability (HRV) obtained from 5-min ECG were gathered. The MDD group showed significantly lower very low frequency power, low frequency power, high frequency power, and total power in frequency domain. In time domain analysis, the MDD group showed a significantly smaller standard deviation of the NN, root mean square of the differences of the successive NN, and NN50/total number of all NNs. These findings demonstrated a lower HRV in older patients who were newly diagnosed with depression without a history of CVD and antidepressants effect, compared with the control subjects. Low HRV may be an important predictor of both MDD and CVD in elderly. The use of HRV in elderly depressive patients could be a meaningful screening method for risk of CVD. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Ha, Jee Hyun] Konkuk Univ, Sch Med, Dept Psychiat, Seoul, South Korea.
   [Park, Soyeon; Kim, Byungsu] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Psychiat, Seoul 136736, South Korea.
   [Yoon, Daehyun] Seoul Natl Univ Hosp, Dept Psychiat, Healthcare Syst Gangnam Ctr, Seoul 110744, South Korea.
   [Kim, Byungsu] Asan Med Ctr, Stress Clin, Hlth Promot Ctr, Seoul, South Korea.
C3 Konkuk University; Konkuk University Medical Center; University of
   Ulsan; Asan Medical Center; Seoul National University (SNU); Seoul
   National University Hospital; University of Ulsan; Asan Medical Center
RP Kim, B (corresponding author), Univ Ulsan, Coll Med, Asan Med Ctr, Dept Psychiat, 88 Olymp Ro 43 Gil, Seoul 136736, South Korea.
EM j993601@gmail.com
RI Kim, Byungsu/JNE-3151-2023
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alexopoulos GS, 2002, BIOL PSYCHIAT, V52, P543, DOI 10.1016/S0006-3223(02)01468-3
   Carney RM, 2005, PSYCHOSOM MED, V67, pS29, DOI 10.1097/01.psy.0000162254.61556.d5
   Carney RM, 2002, J PSYCHOSOM RES, V53, P897, DOI 10.1016/S0022-3999(02)00311-2
   Dekker JM, 2000, CIRCULATION, V102, P1239, DOI 10.1161/01.CIR.102.11.1239
   Ferketich AK, 2000, ARCH INTERN MED, V160, P1261, DOI 10.1001/archinte.160.9.1261
   Friedman EH, 1996, AM J CARDIOL, V77, P330, DOI 10.1016/S0002-9149(97)89419-2
   Fukusaki C, 2000, CLIN AUTON RES, V10, P123, DOI 10.1007/BF02278016
   Glassman Alexander, 2003, J Psychiatr Pract, V9, P409, DOI 10.1097/00131746-200311000-00004
   Gonzalez M B, 1996, Depression, V4, P57, DOI 10.1002/(SICI)1522-7162(1996)4:2<57::AID-DEPR3>3.0.CO;2-C
   Grippo AJ, 2002, NEUROSCI BIOBEHAV R, V26, P941, DOI 10.1016/S0149-7634(03)00003-4
   Jindal RD, 2008, AM J GERIAT PSYCHIAT, V16, P861, DOI 10.1097/JGP.0b013e318180053d
   Kemp AH, 2013, INT J PSYCHOPHYSIOL, V89, P288, DOI 10.1016/j.ijpsycho.2013.06.018
   Kemp AH, 2010, BIOL PSYCHIAT, V67, P1067, DOI [10.1016/j.biopsych.2009.12.012, 10.1016/j.biopsych.2009.11.019]
   Kuo TBJ, 1999, AM J PHYSIOL-HEART C, V277, pH2233, DOI 10.1152/ajpheart.1999.277.6.H2233
   Kupfer DJ, 2012, LANCET, V379, P1045, DOI 10.1016/S0140-6736(11)60602-8
   Lehofer M, 1997, BIOL PSYCHIAT, V42, P914, DOI 10.1016/S0006-3223(96)00494-5
   Li M., 2011, TXB PSYCHOSOMATIC ME, P175
   Licht CMM, 2008, ARCH GEN PSYCHIAT, V65, P1358, DOI 10.1001/archpsyc.65.12.1358
   Luppa M, 2012, J AFFECT DISORDERS, V136, P212, DOI 10.1016/j.jad.2010.11.033
   Martinmäki K, 2006, AM J PHYSIOL-HEART C, V290, pH640, DOI 10.1152/ajpheart.00054.2005
   Moser M, 1998, J AFFECT DISORDERS, V48, P115, DOI 10.1016/S0165-0327(97)00164-X
   Nemeroff CB, 2012, NAT REV CARDIOL, V9, P526, DOI 10.1038/nrcardio.2012.91
   Nobler MS, 1999, BRAIN RES REV, V30, P250, DOI 10.1016/S0165-0173(99)00019-3
   O'Regan C, 2015, PSYCHOL MED, V45, P623, DOI 10.1017/S0033291714001767
   Porges Stephen W, 2009, Cleve Clin J Med, V76 Suppl 2, pS86, DOI 10.3949/ccjm.76.s2.17
   del Paso GAR, 2013, PSYCHOPHYSIOLOGY, V50, P477, DOI 10.1111/psyp.12027
   Rottenberg J, 2007, BIOL PSYCHOL, V74, P200, DOI 10.1016/j.biopsycho.2005.08.010
   Rugulies R, 2002, AM J PREV MED, V23, P51, DOI 10.1016/S0749-3797(02)00439-7
   Serrador J M, 1999, Heart, V82, pe9
   Sinnreich R, 1998, HEART, V80, P156, DOI 10.1136/hrt.80.2.156
   Soares-Miranda L, 2012, DIABETES-METAB RES, V28, P363, DOI 10.1002/dmrr.2281
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Taylor CB, 2010, INT J PSYCHOPHYSIOL, V78, P80, DOI 10.1016/j.ijpsycho.2010.04.006
   Thayer JF, 2002, IEEE ENG MED BIOL, V21, P24, DOI 10.1109/MEMB.2002.1032635
   VAISHNAV S, 1994, AM J CARDIOL, V73, P653, DOI 10.1016/0002-9149(94)90928-8
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vasudev A, 2011, J AFFECT DISORDERS, V131, P374, DOI 10.1016/j.jad.2010.11.001
   VEITH RC, 1994, ARCH GEN PSYCHIAT, V51, P411
   Whiteford HA, 2013, LANCET, V382, P1575, DOI 10.1016/S0140-6736(13)61611-6
   Williams SA, 2002, PSYCHOSOM MED, V64, P6, DOI 10.1097/00006842-200201000-00002
NR 41
TC 29
Z9 33
U1 1
U2 25
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD APR
PY 2015
VL 226
IS 2-3
BP 484
EP 488
DI 10.1016/j.psychres.2015.02.005
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CG2HM
UT WOS:000353095500011
PM 25747680
DA 2025-06-11
ER

PT J
AU Chaudhary, K
   Buddineni, JP
   Nistala, R
   Whaley-Connell, A
AF Chaudhary, Kunal
   Buddineni, J. P.
   Nistala, Ravi
   Whaley-Connell, Adam
TI Resistant Hypertension in the High-Risk Metabolic Patient
SO CURRENT DIABETES REPORTS
LA English
DT Article
DE Resistant hypertension; Metabolic syndrome; Adiponectin
ID ANGIOTENSIN-ALDOSTERONE SYSTEM; NITRIC-OXIDE SYNTHASE;
   SMOOTH-MUSCLE-CELLS; II RECEPTOR BLOCKER; INSULIN-RESISTANCE;
   BLOOD-PRESSURE; ADIPOSE-TISSUE; MINERALOCORTICOID RECEPTOR;
   CARDIOMETABOLIC SYNDROME; VASCULAR INFLAMMATION
AB The metabolic syndrome is a constellation of metabolic and vascular abnormalities that include insulin resistance with compensatory hyperinsulinemia, central or visceral obesity, hypertension, dyslipidemia, microalbuminuria, and oxidative stress as well as prothrombotic and inflammatory abnormalities that contribute to a hypercoagulable state and systemic endothelial dysfunction. Visceral adipose tissue is now known to secrete into the circulation a number of protein and nonprotein factors that regulate glucose metabolism in traditional insulin-sensitive tissue as well as nontraditional insulin-sensitive tissue including cardiovascular tissue. Collectively, this constellation of factors that lead to metabolic dysregulation contributes to a substantial risk for adverse cardiovascular and renal outcomes. The development of a particularly resistant form of hypertension in these individuals can be attributed to a number of factors including vasoconstriction from increased sympathetic activation, proinflammatory cytokines, and inappropriate activation of the renin-angiotensin-aldosterone system. The management of hypertension in such patients can be challenging and generally requires nonpharmacologic as well as pharmacologic interventions.
C1 [Chaudhary, Kunal] Univ Missouri, Hlth Sci Ctr, Harry S Truman Hosp, Columbia, MO 65201 USA.
   [Buddineni, J. P.; Nistala, Ravi; Whaley-Connell, Adam] Univ Missouri, Sch Med, Columbia, MO 65201 USA.
   [Whaley-Connell, Adam] Harry S Truman VA Med Ctr, Columbia, MO USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital
RP Chaudhary, K (corresponding author), Univ Missouri, Hlth Sci Ctr, Harry S Truman Hosp, 800 Hosp Dr, Columbia, MO 65201 USA.
EM chaudharyk@health.missouri.edu
OI Whaley-Connell, Adam/0000-0001-8955-5560
CR Alexander CM, 2003, DIABETES, V52, P1210, DOI 10.2337/diabetes.52.5.1210
   Araki K, 2008, OBESITY, V16, P2068, DOI 10.1038/oby.2008.323
   Bomback AS, 2009, AM J HYPERTENS, V22, P1032, DOI 10.1038/ajh.2009.138
   Bomback AS, 2009, AM J NEPHROL, V30, P140, DOI 10.1159/000209744
   Brown NJ, 2008, HYPERTENSION, V51, P161, DOI 10.1161/HYPERTENSIONAHA.107.095489
   Caprio M, 2007, FASEB J, V21, P2185, DOI 10.1096/fj.06-7970com
   Chen H, 2003, J BIOL CHEM, V278, P45021, DOI 10.1074/jbc.M307878200
   Combs TP, 2002, ENDOCRINOLOGY, V143, P998, DOI 10.1210/en.143.3.998
   Cooper R, 1997, J HUM HYPERTENS, V11, P107, DOI 10.1038/sj.jhh.1000391
   Daimon M, 2003, DIABETES CARE, V26, P2015, DOI 10.2337/diacare.26.7.2015
   Dimmeler S, 1999, NATURE, V399, P601, DOI 10.1038/21224
   Duncan BB, 2004, DIABETES, V53, P2473, DOI 10.2337/diabetes.53.9.2473
   DUSTAN HP, 1983, ANN INTERN MED, V98, P860, DOI 10.7326/0003-4819-98-5-860
   Ebata S, 1999, KIDNEY INT, V56, P1400, DOI 10.1046/j.1523-1755.1999.00674.x
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Furumatsu Y, 2008, HYPERTENS RES, V31, P59, DOI 10.1291/hypres.31.59
   Giannattasio C, 2005, ARTERIOSCL THROM VAS, V25, P406, DOI 10.1161/01.ATV.0000152231.93590.17
   Goldfine AB, 2009, NAT MED, V15, P616, DOI 10.1038/nm0609-616
   Grassi G, 2001, J HYPERTENS, V19, P1713, DOI 10.1097/00004872-200110000-00003
   Greenstein AS, 2009, CIRCULATION, V119, P1661, DOI 10.1161/CIRCULATIONAHA.108.821181
   Guzik TJ, 2007, J PHYSIOL PHARMACOL, V58, P591
   Hall JE, 2010, J BIOL CHEM, V285, P17271, DOI 10.1074/jbc.R110.113175
   Hansmann G, 2007, CIRCULATION, V115, P1275, DOI 10.1161/CIRCULATIONAHA.106.663120
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Kadowaki T, 2006, J CLIN INVEST, V116, P1784, DOI 10.1172/JCI29126
   Katagiri H, 2007, CIRC RES, V101, P27, DOI 10.1161/CIRCRESAHA.107.151621
   Kidambi S, 2007, HYPERTENSION, V49, P704, DOI 10.1161/01.HYP.0000253258.36141.c7
   Kirk EP, 2009, J CLIN HYPERTENS, V11, P761, DOI 10.1111/j.1559-4572.2009.00054.x
   Krakoff J, 2003, DIABETES CARE, V26, P1745, DOI 10.2337/diacare.26.6.1745
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Liao JK, 2002, INT J CARDIOL, V86, P5, DOI 10.1016/S0167-5273(02)00195-X
   Lindsay RS, 2002, LANCET, V360, P57, DOI 10.1016/S0140-6736(02)09335-2
   Massiéra F, 2001, FASEB J, V15, P2727, DOI 10.1096/fj.01-0457fje
   MILLER JH, 1954, J APPL PHYSIOL, V6, P509, DOI 10.1152/jappl.1954.6.8.509
   Miyata Y, 2005, J HYPERTENS, V23, P2237, DOI 10.1097/01.hjh.0000194122.27475.6c
   Mohapatra J, 2009, PHARMACOLOGY, V84, P203, DOI 10.1159/000235996
   Morgan DA, 2008, AM J PHYSIOL-REG I, V295, pR1730, DOI 10.1152/ajpregu.90324.2008
   Moschen AR, 2009, J HEPATOL, V51, P765, DOI 10.1016/j.jhep.2009.06.016
   Ohashi K, 2006, HYPERTENSION, V47, P1108, DOI 10.1161/01.HYP.0000222368.43759.a1
   Probstfield Jeffrey L, 2010, Am J Cardiol, V105, p10A, DOI 10.1016/j.amjcard.2009.10.006
   Qi Y, 2004, NAT MED, V10, P524, DOI 10.1038/nm1029
   Rahmouni K, 2005, HYPERTENSION, V45, P9, DOI 10.1161/01.HYP.0000151325.83008.b4
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   RONDINONE CM, 1993, ENDOCRINOLOGY, V132, P2421, DOI 10.1210/en.132.6.2421
   Sarafidis PA, 2007, J HUM HYPERTENS, V21, P12, DOI 10.1038/sj.jhh.1002103
   Sato A, 2006, HYPERTENS RES, V29, P211, DOI 10.1291/hypres.29.211
   Sechi L A, 1996, Blood Press Suppl, V1, P47
   Shi P, 2010, CLIN EXP PHARMACOL P, V37, pE52, DOI 10.1111/j.1440-1681.2009.05234.x
   Sironi AM, 2004, HYPERTENSION, V44, P127, DOI 10.1161/01.HYP.0000137982.10191.0a
   Sowers J, 2010, J HYPERTENS, V28, pE578, DOI 10.1097/01.hjh.0000379970.75767.bb
   Sowers JR, 2009, ANN INTERN MED, V150, P776, DOI 10.7326/0003-4819-150-11-200906020-00005
   Sowers James R, 2008, Clin Cornerstone, V9, P32, DOI 10.1016/S1098-3597(08)60026-5
   Spranger J, 2003, LANCET, V361, P226, DOI 10.1016/S0140-6736(03)12255-6
   STAMLER R, 1978, JAMA-J AM MED ASSOC, V240, P1607, DOI 10.1001/jama.240.15.1607
   Stevens VJ, 2001, ANN INTERN MED, V134, P1, DOI 10.7326/0003-4819-134-1-200101020-00007
   Tilg H, 2006, NAT REV IMMUNOL, V6, P772, DOI 10.1038/nri1937
   Vaz M, 1997, CIRCULATION, V96, P3423
   Vecchione C, 2002, DIABETES, V51, P168, DOI 10.2337/diabetes.51.1.168
   Whaley-Connell A, 2009, AM J PHYSIOL-RENAL, V296, pF1013, DOI 10.1152/ajprenal.90646.2008
   Yamauchi T, 2001, NAT MED, V7, P941, DOI 10.1038/90984
   Yu Y, 2004, J AM COLL CARDIOL, V44, P904, DOI 10.1016/j.jacc.2004.04.050
   Ziccardi P, 2002, CIRCULATION, V105, P804, DOI 10.1161/hc0702.104279
NR 63
TC 17
Z9 18
U1 0
U2 0
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1534-4827
J9 CURR DIABETES REP
JI Curr. Diabetes Rep.
PD FEB
PY 2011
VL 11
IS 1
BP 41
EP 46
DI 10.1007/s11892-010-0155-x
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 729GA
UT WOS:000287935500006
PM 20941645
DA 2025-06-11
ER

PT S
AU Winer, N
   Sowers, JR
AF Winer, Nathaniel
   Sowers, James R.
BE Safar, ME
   Frohlich, ED
TI Diabetes and arterial stiffening
SO ATHEROSCLEROSIS, LARGE ARTERIES AND CARDIOVASCULAR RISK
SE Advances in Cardiology
LA English
DT Article
ID METABOLIC SYNDROME; CAROTID-ARTERY; STIFFNESS; GLUCOSE; INCREASES;
   DISEASE
AB Type 2 diabetes (DM-2) has become a major global health problem that has been fueled mainly by increasing obesity and aging of the population. Most studies show that arterial stiffening occurs across all age groups in both type I diabetes and DM-2, and among those with impaired fasting glucose, impaired glucose tolerance, and the metabolic syndrome. Arterial stiffening in DM-2 results, in part, from the clustering of hyperglycemia, dyslipidernia and hypertension, all of which may promote insulin resistance, oxidative stress, endothelial dysfunction, and the formation of pro-inflammatory cytokines and advanced glycosylation end-products. Likewise, aging may increase arterial stiffening by altering the proportions of elastin and collagen in the aorta. The consequences of arterial stiffening are increased pulse pressure, hypertension, and a greater risk of cardiovascular disease. Treatment strategies to reduce or prevent arterial stiffening include pharmacologic agents that block the renin-angiotensin-aldosterone system, relax vascular smooth muscle, enhance release of nitric oxide from endothelial cells, and break glycosylation end-product cross-links, and fish oil supplementation. Copyright (c) 2007 S. Karger AG, Basel.
C1 Suny Downstate Med Ctr, Div Endocrinol Diabet & Hypertens, New York, NY USA.
   Univ Missouri, Sch Med, Columbia, MO USA.
   Univ Missouri, Harry S Truman Vet Affairs Med Ctr, Columbia, MO USA.
C3 State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University; University of Missouri System; University of
   Missouri Columbia; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Harry S. Truman Memorial Veterans' Hospital;
   University of Missouri System; University of Missouri Columbia
RP Winer, N (corresponding author), Suny Downstate Med Ctr, Div Endocrinol Diabet & Hypertens, Box 1205,450 Clarkson Ave, Brooklyn, NY 11203 USA.
EM nwiner@downstate.edu
CR [Anonymous], 2002, DIABETES CARE, V26, P917
   Bakris GL, 2004, AM J HYPERTENS, V17, p23S, DOI 10.1016/j.amjhyper.2004.08.022
   Ferreira I, 2005, ARCH INTERN MED, V165, P875, DOI 10.1001/archinte.165.8.875
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Henry RMA, 2003, CIRCULATION, V107, P2089, DOI 10.1161/01.CIR.0000065222.34933.FC
   Kureishi Y, 2000, NAT MED, V6, P1004, DOI 10.1038/79510
   Lacolley P, 2002, CIRCULATION, V106, P2848, DOI 10.1161/01.CIR.0000039328.33137.6C
   MCVEIGH GE, 1993, DIABETOLOGIA, V36, P33, DOI 10.1007/BF00399090
   MCVEIGH GE, 1994, ARTERIOSCLER THROMB, V14, P1425, DOI 10.1161/01.ATV.14.9.1425
   O'Rourke MF, 2005, HYPERTENSION, V46, P200, DOI 10.1161/01.HYP.0000168052.00426.65
   Ohshita K, 2004, DIABETIC MED, V21, P636, DOI 10.1111/j.1464-5491.2004.01161.x
   SALOMAA V, 1995, CIRCULATION, V91, P1432, DOI 10.1161/01.CIR.91.5.1432
   Schram MT, 2004, HYPERTENSION, V43, P176, DOI 10.1161/01.HYP.0000111829.46090.92
   Schram MT, 2002, J HYPERTENS, V20, P1743, DOI 10.1097/00004872-200209000-00017
   Scuteri A, 2004, J AM COLL CARDIOL, V43, P1388, DOI 10.1016/j.jacc.2003.10.061
   Tanaka H, 2000, CIRCULATION, V102, P1270, DOI 10.1161/01.CIR.102.11.1270
   Ting HH, 1996, J CLIN INVEST, V97, P22, DOI 10.1172/JCI118394
   Tomiyama H, 2005, HYPERTENSION, V45, P997, DOI 10.1161/01.HYP.0000165018.63523.8a
   Tounian P, 2001, LANCET, V358, P1400, DOI 10.1016/S0140-6736(01)06525-4
   Urbina EM, 2004, ATHEROSCLEROSIS, V176, P157, DOI 10.1016/j.atherosclerosis.2004.04.023
   van Popele NM, 2000, DIABETOLOGIA, V43, P665, DOI 10.1007/s001250051356
   White WB, 2003, HYPERTENSION, V41, P1021, DOI 10.1161/01.HYP.0000067463.13172.EA
   Whiteley L, 2005, DIABETES CARE, V28, P1588, DOI 10.2337/diacare.28.7.1588
   Wild S, 2004, DIABETES CARE, V27, P1047, DOI 10.2337/diacare.27.5.1047
   Winer N, 2001, J Clin Hypertens (Greenwich), V3, P145, DOI 10.1111/j.1524-6175.2001.00704.x
   Winer N, 2004, J CLIN PHARMACOL, V44, P397, DOI 10.1177/0091270004263017
   Winer Nathaniel, 2003, Curr Diab Rep, V3, P230, DOI 10.1007/s11892-003-0069-y
   Ziv E, 1995, LESSONS ANIMAL DIABE, P285
NR 28
TC 16
Z9 18
U1 0
U2 5
PU KARGER
PI BASEL
PA POSTFACH, CH-4009 BASEL, SWITZERLAND
SN 0065-2326
EI 1662-2839
BN 978-3-8055-8176-9
J9 ADV CARDIOL
JI Adv.Cardiol.
PY 2007
VL 44
BP 245
EP 251
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA BFP84
UT WOS:000243670800018
PM 17075213
DA 2025-06-11
ER

PT J
AU Gallo, LC
   Carlson, JA
   Sotres-Alvarez, D
   Sallis, JF
   Jankowska, MM
   Roesch, SC
   Gonzalez, F
   Geremia, CM
   Talavera, GA
   Rodriguez, TM
   Castañeda, SF
   Allison, MA
AF Gallo, Linda C.
   Carlson, Jordan A.
   Sotres-Alvarez, Daniela
   Sallis, James F.
   Jankowska, Marta M.
   Roesch, Scott C.
   Gonzalez, Franklyn, II
   Geremia, Carrie M.
   Talavera, Gregory A.
   Rodriguez, Tasi M.
   Castaneda, Sheila F.
   Allison, Matthew A.
TI The Hispanic Community Health Study/Study of Latinos Community and
   Surrounding Areas Study: sample, design, and procedures
SO ANNALS OF EPIDEMIOLOGY
LA English
DT Article
DE Cardiovascular; Depression; Environment; Hispanic; Latino; Neighborhood;
   Physical activity; Risk factors
ID GEOGRAPHIC LIFE ENVIRONMENTS; PHYSICAL-ACTIVITY; BUILT ENVIRONMENT;
   METABOLIC SYNDROME; RISK-FACTORS; DIVERSE BACKGROUNDS; MICROSCALE AUDIT;
   HISPANICS/LATINOS; PREVALENCE; ASSOCIATIONS
AB Purpose: We describe the sample, design, and procedures for the Community and Surrounding Areas Study (CASAS), an ancillary to the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). The aim of SOL CASAS was to test an ecological model of macro- and micro-neighborhood environment factors, intermediate behavioral (physical activity) and psychosocial (e.g., depression and stress) mechanisms, and changes in cardiometabolic health in Hispanics/Latinos.
   Methods: Between 2015 and 2017, approximately 6 years after the HCHS/SOL baseline (2008-2011), 1776 San Diego HCHS/SOL participants enrolled in SOL CASAS and completed a repeat physical activity assessment. Participants' residential addresses were geoprocessed, and macroenvironmental features of the home were derived from publicly available data concurrent with the HCHS/SOL baseline and Visit 2 (2014-2017). Microscale environmental attributes were coded for 943 unique routes for 1684 participants, with a validated observational tool, concurrent with Visit 2, for SOL CASAS participants only.
   Results: Of 2520 HCHS/SOL participants approached, 70.5% enrolled (mean age 55.3 years; 94% Mexican; 67.5% female). Accelerometer adherence (three or more days with at least 10 hours wear time) was outstanding (94%).
   Conclusions: With its more comprehensive ecological model and well-characterized Hispanic/Latino population, SOL CASAS will advance the science concerning the contribution of neighborhood factors to cardiometabolic health. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Gallo, Linda C.; Roesch, Scott C.] San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA.
   [Carlson, Jordan A.] Childrens Mercy, Dept Pediat, Kansas City, MO USA.
   [Sotres-Alvarez, Daniela; Gonzalez, Franklyn, II] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Biostat, Collaborat Studies Coordinating Ctr, Chapel Hill, NC 27515 USA.
   [Sallis, James F.; Geremia, Carrie M.; Allison, Matthew A.] Univ Calif San Diego, Sch Med, Dept Family Med & Publ Hlth, San Diego, CA 92103 USA.
   [Jankowska, Marta M.] Univ Calif San Diego, Qualcomm Inst, Calit2, San Diego, CA 92103 USA.
   [Talavera, Gregory A.; Castaneda, Sheila F.] San Diego State Univ, Sch Publ Hlth, San Diego, CA 92182 USA.
   [Rodriguez, Tasi M.] San Diego State Univ, Res Fdn, San Diego, CA 92182 USA.
C3 California State University System; San Diego State University;
   Children's Mercy Hospital; University of North Carolina; University of
   North Carolina Chapel Hill; University of California System; University
   of California San Diego; University of California System; University of
   California San Diego; California State University System; San Diego
   State University; California State University System; San Diego State
   University
RP Gallo, LC (corresponding author), San Diego State Univ, South Bay Latino Res Ctr, Dept Psychol, 780 Bay Blvd, Chula Vista, CA 91910 USA.
EM lgallo@sdsu.edu
RI Sotres-Alvarez, Daniela/O-9085-2016; Sallis, James/D-3001-2014;
   Castaneda, Sheila/AAK-3025-2020; Castaneda, Sheila/I-4132-2014
OI Geremia, Carrie/0000-0001-9159-8172; Castaneda,
   Sheila/0000-0002-1975-0544
FU National Heart, Lung, and Blood Institute
   [HHSN268201300001I/N01-HC-65233, HHSN268201300004I/N01-HC-65234,
   HHSN268201300002I/N01-HC-65235, HHSN268201300003I/N01-HC-65236,
   HHSN26820130000500I-HC-65237]; National Institutes of Health/National
   Institute of Diabetes and Digestive and Kidney Diseases [5 R01 DK106209]
FX The Hispanic Community Health Study/Study of Latinos is a collaborative
   study supported by contracts from the National Heart, Lung, and Blood
   Institute to the University of North Carolina
   (HHSN268201300001I/N01-HC-65233), University of Miami
   (HHSN268201300004I/N01-HC-65234), Albert Einstein College of Medicine
   (HHSN268201300002I/N01-HC-65235), University of Illinois at Chicago
   (HHSN268201300003I/N01-HC-65236 Northwestern University), and San Diego
   State University (HHSN26820130000500I-HC-65237). The following
   institutes/centers/offices have contributed to the HCHS/SOL through a
   transfer of funds to the NHLBI: National Institute on Minority Health
   and Health Disparities, National Institute on Deafness and Other
   Communication Disorders, National Institute of Dental and Craniofacial
   Research, National Institute of Diabetes and Digestive and Kidney
   Diseases, National Institute of Neurological Disorders and Stroke,
   Office of Dietary Supplements. SOL CASAS is supported by the National
   Institutes of Health/National Institute of Diabetes and Digestive and
   Kidney Diseases (5 R01 DK106209; Allison/Gallo mPls). The authors thank
   the staff and participants of HCHS/SOL and SOL CASAS for their important
   contributions.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   ANDRESEN EM, 1994, AM J PREV MED, V10, P77, DOI 10.1016/S0749-3797(18)30622-6
   [Anonymous], 2017, National Diabetes Statistics Report, P20
   Arguelles W, 2015, INT J CARDIOL, V184, P373, DOI 10.1016/j.ijcard.2015.02.100
   Arredondo EM, 2016, AM J PREV MED, V50, P500, DOI 10.1016/j.amepre.2015.08.029
   Bromberger JT, 1996, PSYCHOL AGING, V11, P207, DOI 10.1037/0882-7974.11.2.207
   Brownson RC, 2009, AM J PREV MED, V36, pS99, DOI 10.1016/j.amepre.2009.01.005
   Bull FC, 2009, J PHYS ACT HEALTH, V6, P790, DOI 10.1123/jpah.6.6.790
   Cain KL, 2017, J TRANSP HEALTH, V5, P84, DOI 10.1016/j.jth.2017.05.004
   Cain KL, 2014, SOC SCI MED, V116, P82, DOI 10.1016/j.socscimed.2014.06.042
   Chaix B, 2009, ANNU REV PUBL HEALTH, V30, P81, DOI 10.1146/annurev.publhealth.031308.100158
   Christine PJ, 2015, JAMA INTERN MED, V175, P1311, DOI 10.1001/jamainternmed.2015.2691
   Cohen Sheldon, 1985, Social support: Theory, research and applications, P73, DOI DOI 10.1007/978-94-009-5115-05
   Creatore MI, 2016, JAMA-J AM MED ASSOC, V315, P2211, DOI 10.1001/jama.2016.5898
   Daviglus ML, 2012, JAMA-J AM MED ASSOC, V308, P1775, DOI 10.1001/jama.2012.14517
   den Braver NR, 2018, BMC MED, V16, DOI 10.1186/s12916-017-0997-z
   Edwards JR, 2007, PSYCHOL METHODS, V12, P1, DOI 10.1037/1082-989X.12.1.1
   Enders C.K., 2010, Applied missing data analysis
   Evans GW, 2003, J URBAN HEALTH, V80, P536, DOI 10.1093/jurban/jtg063
   Evenson KR, 2015, MED SCI SPORT EXER, V47, P725, DOI 10.1249/MSS.0000000000000478
   Gallo LC, 2014, PSYCHOSOM MED, V76, P468, DOI 10.1097/PSY.0000000000000069
   Glass TA, 2006, SOC SCI MED, V62, P1650, DOI 10.1016/j.socscimed.2005.08.044
   Gong Y, 2016, ENVIRON INT, V96, P48, DOI 10.1016/j.envint.2016.08.019
   González P, 2017, PSYCHOL ASSESSMENT, V29, P372, DOI 10.1037/pas0000330
   Heiss G, 2014, DIABETES CARE, V37, P2391, DOI 10.2337/dc13-2505
   Isasi CR, 2015, J OBES, V2015, DOI 10.1155/2015/186276
   Kim D, 2008, EPIDEMIOL REV, V30, P101, DOI 10.1093/epirev/mxn009
   Lavange LM, 2010, ANN EPIDEMIOL, V20, P642, DOI 10.1016/j.annepidem.2010.05.006
   Leal C, 2011, OBES REV, V12, P217, DOI 10.1111/j.1467-789X.2010.00726.x
   Llabre MM, 2015, ANN EPIDEMIOL, V25, P480, DOI 10.1016/j.annepidem.2015.02.010
   Malambo P, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0166846
   Mayne SL, 2015, OBES REV, V16, P362, DOI 10.1111/obr.12269
   McCormack GR, 2011, INT J BEHAV NUTR PHY, V8, DOI 10.1186/1479-5868-8-125
   Mehta V, 2007, J PLAN EDUC RES, V27, P165, DOI 10.1177/0739456X07307947
   Merchant Gina, 2015, Prev Med Rep, V2, P845, DOI 10.1016/j.pmedr.2015.09.019
   Merz EL, 2014, PSYCHOL ASSESSMENT, V26, P384, DOI 10.1037/a0035248
   Millstein RA, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-403
   Norman GJ, 2013, AM J HEALTH BEHAV, V37, P277, DOI 10.5993/AJHB.37.2.15
   Phillips CB, 2017, INT J HEALTH GEOGR, V16, DOI 10.1186/s12942-017-0101-0
   Ribeiro AI, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15061092
   Rodriguez CJ, 2014, AM J MED, V127, P1186, DOI 10.1016/j.amjmed.2014.07.026
   Sallis J.F., 2008, HLTH BEHAV HLTH ED T, P485
   Sallis JF, 2012, CIRCULATION, V125, P729, DOI 10.1161/CIRCULATIONAHA.110.969022
   Sallis JF, 2009, SOC SCI MED, V68, P1285, DOI 10.1016/j.socscimed.2009.01.017
   Schneiderman N, 2014, DIABETES CARE, V37, P2233, DOI 10.2337/dc13-2939
   Schüle SA, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0123456
   Sorlie PD, 2014, AM J HYPERTENS, V27, P793, DOI 10.1093/ajh/hpu003
   Sorlie PD, 2010, ANN EPIDEMIOL, V20, P629, DOI 10.1016/j.annepidem.2010.03.015
   South EC, 2018, JAMA NETW OPEN, V1, DOI 10.1001/jamanetworkopen.2018.0298
   Spitzer RL, 2006, ARCH INTERN MED, V166, P1092, DOI 10.1001/archinte.166.10.1092
   Thoemmes F, 2010, STRUCT EQU MODELING, V17, P510, DOI 10.1080/10705511.2010.489379
   Tofighi D, 2011, BEHAV RES METHODS, V43, P692, DOI 10.3758/s13428-011-0076-x
   Vespa J., 2020, CURRENT POPULATION R
   White J, 2017, AM J EPIDEMIOL, V186, P473, DOI 10.1093/aje/kwx086
NR 54
TC 16
Z9 19
U1 1
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1047-2797
EI 1873-2585
J9 ANN EPIDEMIOL
JI Ann. Epidemiol.
PD FEB
PY 2019
VL 30
BP 57
EP 65
DI 10.1016/j.annepidem.2018.11.002
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA HM1RK
UT WOS:000459230100008
PM 30551973
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Ras, J
   Grace, J
AF Ras, Jaron
   Grace, Jeanne
TI Association Between Metabolic Syndrome and Physical Fitness in
   Firefighters in Cape Town, South Africa
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
DE aerobic capacity; cardiometabolic; endurance; fitness; hyperglycemia;
   hypertension; obesity; strength
ID CARDIORESPIRATORY FITNESS; MUSCULOSKELETAL HEALTH; PREVALENCE;
   PREDICTORS; STRENGTH; STRESS; RISK; MEN
AB Objective: To assess the relationship between metabolic syndrome (MetS) and physical fitness in firefighters. Methods: Firefighters (n = 309) were systematically recruited to participate in this study. A questionnaire and physical measures were used to collect data on firefighters' cardiometabolic health and physical fitness levels. Data were analyzed using binary and multinomial logistic regressions. Results: The prevalence of MetS was 23.0%, which was most prevalent in station and platoon commanders. Multivariable analysis showed that age (P < 0.001), lean body mass (P < 0.001), absolute aerobic capacity (P < 0.001), and leg strength (P < 0.001) was significantly associated with MetS. In addition, relative aerobic capacity (P < 0.001), push-ups (P = 0.016), and sit-ups (P < 0.001) were inversely associated with MetS. Conclusions: Firefighters with MetS had a higher absolute aerobic capacity and strength, and healthier fighters had a higher relative aerobic capacity, muscular endurance capacity, and flexibility.
C1 [Ras, Jaron; Grace, Jeanne] Univ Kwazulu Natal, Coll Hlth Sci, Discipline Biokinet Exercise & Leisure Sci, 238 Mazisi Kunene Rd, ZA-4041 Durban, South Africa.
C3 University of Kwazulu Natal
RP Ras, J (corresponding author), Univ Kwazulu Natal, Coll Hlth Sci, Discipline Biokinet Exercise & Leisure Sci, 238 Mazisi Kunene Rd, ZA-4041 Durban, South Africa.
EM rasj1@ukzn.ac.za; gracej@ukzn.ac.za
RI Ras, Jaron/KIX-7482-2024; Ras, Jaron/AAJ-9901-2021
OI Ras, Jaron/0000-0002-7915-4883
CR Bastianelli Karen, 2017, J Pharm Pract, V30, P490, DOI 10.1177/0897190016651546
   Baur Dorothee M, 2012, J Obes, V2012, P710903, DOI 10.1155/2012/710903
   Baur DM, 2012, J STRENGTH COND RES, V26, P2331, DOI 10.1519/JSC.0b013e31823e9b19
   Beckett Ashley, 2023, Int J Environ Res Public Health, V20, DOI 10.3390/ijerph20196814
   Bianco A, 2015, SPRINGERPLUS, V4, DOI 10.1186/s40064-015-1023-6
   Byeon JY, 2019, METAB SYNDR RELAT D, V17, P280, DOI 10.1089/met.2018.0111
   Choi B, 2017, AM J IND MED, V60, P900, DOI 10.1002/ajim.22752
   COLDWELLS A, 1994, ERGONOMICS, V37, P79, DOI 10.1080/00140139408963625
   Donovan R, 2009, OCCUP MED-OXFORD, V59, P487, DOI 10.1093/occmed/kqp095
   Ensari I, 2017, ERGONOMICS, V60, P657, DOI 10.1080/00140139.2016.1198496
   Faulkner JL, 2019, BIOL SEX DIFFER, V10, DOI 10.1186/s13293-019-0246-6
   Frost DM, 2015, WORK, V52, P835, DOI 10.3233/WOR-152111
   Gaughan DM, 2014, AM J IND MED, V57, P748, DOI 10.1002/ajim.22331
   Guarner-Lans V, 2011, EXP GERONTOL, V46, P517, DOI 10.1016/j.exger.2011.02.007
   HILYER JC, 1990, J OCCUP ENVIRON MED, V32, P631, DOI 10.1097/00043764-199007000-00015
   Hong S, 2019, J OBES METAB SYNDR, V28, P53, DOI 10.7570/jomes.2019.28.1.53
   Kajuluri Lova Prasadareddy, 2021, Explor Med, V2, P186, DOI 10.37349/emed.2021.00041
   Ko KJ, 2019, DIABETES METAB SYND, V13, P536, DOI 10.1016/j.dsx.2018.11.025
   Lee W, 2017, J OCCUP ENVIRON MED, V59, P384, DOI [10.1097/JOM.0000000000000956, 10.1097/jom.0000000000000956]
   Leischik R, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0133113
   Liguori G, 2021, Acsm's Guidelines for Exercise Testing and Prescription, V11th
   Mears MJ, 2022, LIFE SCI, V289, DOI 10.1016/j.lfs.2021.120147
   Mileski KSL, 2015, J SPORT MED PHYS FIT, V55, P223
   Misigoj-Durakovic M, 2016, OBESITY, V24, P238, DOI 10.1002/oby.21264
   Miyatake N., 2009, Anti-Aging Med, V6, P1
   Myers J, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071652
   Navarro KM, 2019, ENVIRON RES, V173, P462, DOI 10.1016/j.envres.2019.03.060
   Nazari G, 2020, J MIL VETERAN FAM HL, V6, P83, DOI 10.3138/jmvfh-2019-0024
   Nowak A.M., 2018, Advances in Rehabilitation, V32, P13, DOI [DOI 10.5114/AREH.2018.77933, 10.5114/areh.2018, DOI 10.5114/AREH.2018]
   Rajabi F, 2020, HELIYON, V6, DOI 10.1016/j.heliyon.2020.e03820
   Ras J., 2024, Phys Act Health, V8, P47
   Ras J, 2024, BMC PUBLIC HEALTH, V24, DOI 10.1186/s12889-023-17487-6
   Ras J, 2023, FRONT PUBLIC HEALTH, V11, DOI 10.3389/fpubh.2023.1241250
   Ras J, 2023, FRONT PHYSIOL, V14, DOI 10.3389/fphys.2023.1210107
   Ras J, 2023, J OCCUP ENVIRON MED, V65, pE496, DOI 10.1097/JOM.0000000000002872
   Ras Jaron, 2023, Int J Environ Res Public Health, V20, DOI 10.3390/ijerph20115930
   Ras J, 2022, EUR J INVEST HEALTH, V12, P1703, DOI 10.3390/ejihpe12110120
   Ras J, 2022, J OCCUP ENVIRON MED, V64, pE705, DOI 10.1097/JOM.0000000000002679
   Ras J, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph191911946
   Ras J, 2022, BMJ OPEN, V12, DOI 10.1136/bmjopen-2022-061435
   Ras J, 2022, INQUIRY-J HEALTH CAR, V59, DOI 10.1177/00469580221084485
   Ras J, 2022, J PUBLIC HEALTH RES, V11, DOI 10.4081/jphr.2021.2307
   Rexhepi A M., 2014, Human Movement, V15, P56, DOI [10.2478/humo-2014-0003, DOI 10.2478/HUMO-2014-0003]
   Sekgala MD, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.974749
   Sénéchal M, 2014, MED SCI SPORT EXER, V46, P1475, DOI 10.1249/MSS.0000000000000266
   Shin JH, 2016, ANN OCCUP ENVIRON ME, V28, DOI 10.1186/s40557-016-0111-6
   Skinner TL, 2020, J SCI MED SPORT, V23, P1228, DOI 10.1016/j.jsams.2020.05.013
   Smith DL, 2018, J AM HEART ASSOC, V7, DOI 10.1161/JAHA.118.009446
   Smith DL, 2016, EXERC SPORT SCI REV, V44, P90, DOI 10.1249/JES.0000000000000081
   Smith DL, 2013, EXTREME PHYSIOL MED, V2, DOI 10.1186/2046-7648-2-6
   Smith LJ, 2019, INT J STRESS MANAGE, V26, P367, DOI 10.1037/str0000118
   Strauss M, 2016, DIABETOL METAB SYNDR, V8, DOI 10.1186/s13098-016-0174-0
   Templeton GF, 2011, COMMUN ASSOC INF SYS, V28, P41
   Wittekind SG, 2020, MED SCI SPORT EXER, V52, P2574, DOI 10.1249/MSS.0000000000002424
   Wu HM, 2019, METABOLISM, V93, P61, DOI 10.1016/j.metabol.2019.01.011
   Yang J, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0127001
   Yang J, 2019, JAMA NETW OPEN, V2, DOI 10.1001/jamanetworkopen.2018.8341
   Zeiher J, 2019, SPORTS MED-OPEN, V5, DOI 10.1186/s40798-019-0211-2
NR 58
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1076-2752
EI 1536-5948
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD DEC
PY 2024
VL 66
IS 12
BP e646
EP e652
DI 10.1097/JOM.0000000000003250
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA O1L5I
UT WOS:001368827800008
PM 39621962
DA 2025-06-11
ER

PT J
AU Chambers, TJG
   Anderson, RA
AF Chambers, Thomas J. G.
   Anderson, Richard A.
TI The impact of obesity on male fertility
SO HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE Fertility; Hypogonadism; Infertility; Metabolic syndrome; Overweight;
   Paternal; Sperm
ID BODY-MASS INDEX; ASSISTED REPRODUCTIVE TECHNOLOGY; SEMEN QUALITY;
   METABOLIC SYNDROME; BARIATRIC SURGERY; PATERNAL OBESITY; OXIDATIVE
   STRESS; OLDER MEN; DIET; HYPOGONADISM
AB Obesity in men of reproductive age is globally on the increase. There is clear evidence from epidemiological studies that obesity impacts negatively on male fertility; it is associated with hypogonadism, although it is less consistently linked to impaired spermatogenesis and tests of sperm function, including DNA fragmentation. Sperm from obese men used for in vitro fertilisation/intra cytoplasmic sperm injection is associated with a greater number of pregnancy losses and is less likely to result in live births. There are also increasing data from animal studies that paternal obesity may impact negatively on the reproductive and metabolic health of offspring and grand-offspring. It has been suggested that high-fat dietary exposures could affect the epigenetic content of sperm or the endocrine content of seminal fluid and thus impact early fetal development. Experimental and epidemiological data show that male fertility, and offspring health, can be improved by weight loss in obese and overweight males.
C1 [Chambers, Thomas J. G.; Anderson, Richard A.] Univ Edinburgh, Queens Med Res Inst, MRC Ctr Reprod Hlth, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, Scotland.
C3 University of Edinburgh
RP Anderson, RA (corresponding author), Univ Edinburgh, Queens Med Res Inst, MRC Ctr Reprod Hlth, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, Scotland.
EM richard.anderson@ed.ac.uk
RI Chambers, Tom/AAJ-7880-2020
OI Chambers, Thomas/0000-0001-6823-6915
FU MRC [MR/K500938/1, G1002033] Funding Source: UKRI; Medical Research
   Council [G1002033, MR/K500938/1] Funding Source: Medline
CR Aitken RJ, 2014, ASIAN J ANDROL, V16, P31, DOI 10.4103/1008-682X.122203
   Anderson LM, 2006, NUTRITION, V22, P327, DOI 10.1016/j.nut.2005.09.006
   [Anonymous], 2014, Obesity and Overweight
   [Anonymous], 2013, NATL VITAL STA REP
   Bakos HW, 2011, FERTIL STERIL, V95, P1700, DOI 10.1016/j.fertnstert.2010.11.044
   Barratt CLR, 2010, HUM REPROD, V25, P824, DOI 10.1093/humrep/dep465
   Belan M, 2015, IMPACTS LIFESTYLE AN
   Binder NK, 2015, MOL HUM REPROD, V21, P424, DOI 10.1093/molehr/gav010
   Bromfield JJ, 2014, P NATL ACAD SCI USA, V111, P2200, DOI 10.1073/pnas.1305609111
   Camacho EM, 2013, EUR J ENDOCRINOL, V168, P445, DOI 10.1530/EJE-12-0890
   Carone BR, 2010, CELL, V143, P1084, DOI 10.1016/j.cell.2010.12.008
   Colaci DS, 2012, FERTIL STERIL, V98, P1193, DOI 10.1016/j.fertnstert.2012.07.1102
   Corona G, 2013, EUR J ENDOCRINOL, V168, P829, DOI 10.1530/EJE-12-0955
   Crean AJ, 2014, ECOL LETT, V17, P1545, DOI 10.1111/ele.12373
   Curley JP, 2011, HORM BEHAV, V59, P306, DOI 10.1016/j.yhbeh.2010.06.018
   Eisenberg ML, 2014, HUM REPROD, V29, P193, DOI 10.1093/humrep/det428
   Fariello RM, 2012, BJU INT, V110, P863, DOI 10.1111/j.1464-410X.2011.10813.x
   Fullston T, 2012, HUM REPROD, V27, P1391, DOI 10.1093/humrep/des030
   Fullston T, 2015, PHYSIOL REP, V3, DOI 10.14814/phy2.12336
   Fullston T, 2013, FASEB J, V27, P4226, DOI 10.1096/fj.12-224048
   Håkonsen LB, 2011, REPROD HEALTH, V8, DOI 10.1186/1742-4755-8-24
   Jääskeläinen A, 2011, INT J OBESITY, V35, P1289, DOI 10.1038/ijo.2011.150
   Jensen TK, 2004, FERTIL STERIL, V82, P863, DOI 10.1016/j.fertnstert.2004.03.056
   Jorgensen N, 2012, BMJ OPEN, V2, DOI 10.1136/bmjopen-2012-000990
   Kaati G, 2007, EUR J HUM GENET, V15, P784, DOI 10.1038/sj.ejhg.5201832
   Kaya E, 2015, J SEX MED, V12, P856, DOI 10.1111/jsm.12828
   Kort HI, 2006, J ANDROL, V27, P450, DOI 10.2164/jandrol.05124
   Lane M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100832
   Lazaros L, 2012, ANDROLOGIA, V44, P428, DOI 10.1111/j.1439-0272.2012.01300.x
   Le Cornet C, 2014, EUR J CANCER, V50, P831, DOI 10.1016/j.ejca.2013.11.035
   MacDonald AA, 2010, HUM REPROD UPDATE, V16, P293, DOI 10.1093/humupd/dmp047
   McPherson NO, 2015, AM J PHYSIOL-ENDOC M, V308, pE805, DOI 10.1152/ajpendo.00013.2015
   McPherson NO, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071459
   Moragianni VA, 2012, FERTIL STERIL, V98, DOI 10.1016/j.fertnstert.2012.04.004
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Ng SF, 2010, NATURE, V467, P963, DOI 10.1038/nature09491
   Nguyen RHN, 2007, HUM REPROD, V22, P2488, DOI 10.1093/humrep/dem139
   Öst A, 2014, CELL, V159, P1352, DOI 10.1016/j.cell.2014.11.005
   Patro B, 2013, ANN NUTR METAB, V63, P32, DOI 10.1159/000350313
   Priskorn L, 2012, INT J ANDROL, V35, P449, DOI 10.1111/j.1365-2605.2012.01265.x
   Ramlau-Hansen CH, 2007, HUM REPROD, V22, P1634, DOI 10.1093/humrep/dem035
   Rastrelli G, 2015, J CLIN ENDOCR METAB, V100, P3172, DOI 10.1210/jc.2015-1571
   Reis LO, 2012, REPROD SCI, V19, P1057, DOI 10.1177/1933719112440747
   Roa J, 2014, MOL CELL ENDOCRINOL, V397, P4, DOI 10.1016/j.mce.2014.09.027
   Rolland M, 2013, HUM REPROD, V28, P462, DOI 10.1093/humrep/des415
   Romero-Otero J, 2015, UROLOGY, V85, P1333, DOI 10.1016/j.urology.2015.02.001
   Sallmén M, 2006, EPIDEMIOLOGY, V17, P520, DOI 10.1097/01.ede.0000229953.76862.e5
   Sermondade N, 2012, REPROD BIOMED ONLINE, V24, P206, DOI 10.1016/j.rbmo.2011.10.014
   Tunc O, 2011, ANDROLOGIA, V43, P121, DOI 10.1111/j.1439-0272.2009.01032.x
   VERMEULEN A, 1993, J CLIN ENDOCR METAB, V76, P1140, DOI 10.1210/jc.76.5.1140
   Wang YC, 2011, LANCET, V378, P815, DOI 10.1016/S0140-6736(11)60814-3
   Wu FCW, 2008, J CLIN ENDOCR METAB, V93, P2737, DOI 10.1210/jc.2007-1972
   Zini A, 2011, J ASSIST REPROD GEN, V28, P391, DOI 10.1007/s10815-011-9544-6
   Zini A, 2008, HUM REPROD, V23, P2663, DOI 10.1093/humrep/den321
NR 54
TC 50
Z9 56
U1 1
U2 23
PU HELLENIC ENDOCRINE SOC
PI ATHENS
PA 14 ALEXANDRAS AVE, ATHENS, 106 82, GREECE
SN 1109-3099
J9 HORM-INT J ENDOCRINO
JI Horm.-Int. J. Endocrinol. Metab.
PD OCT-DEC
PY 2015
VL 14
IS 4
BP 563
EP 568
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DD9KG
UT WOS:000370243500008
PM 26732149
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Robles-Almazan, M
   Pulido-Moran, M
   Moreno-Fernandez, J
   Ramirez-Tortosa, C
   Rodriguez-Garcia, C
   Quiles, JL
   Ramirez-Tortosa, M
AF Robles-Almazan, Maria
   Pulido-Moran, Mario
   Moreno-Fernandez, Jorge
   Ramirez-Tortosa, Cesar
   Rodriguez-Garcia, Carmen
   Quiles, Jose L.
   Ramirez-Tortosa, MCarmen
TI Hydroxytyrosol: Bioavailability, toxicity, and clinical applications
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Review
DE Hydroxytyrosol; Olive oil; Chronic diseases; Inflammation; Reactive
   oxygen species (ROS); Cancer
ID VIRGIN OLIVE OIL; FATTY-ACID SYNTHASE; REDUCES OXIDATIVE STRESS; HUMAN
   HEPATOMA HEPG2; WASTE-WATER EXTRACT; INDUCED DNA-DAMAGE;
   PHENOLIC-COMPOUNDS; OLEA-EUROPAEA; IN-VITRO; METABOLIC SYNDROME
AB Many beneficial properties have been attributed to the Mediterranean diet. Over the years, researchers have attempted to learn which foods and which food components are responsible for good health. One of these components is hydroxytyrosol, an important phenolic compound present in olive oil.
   Hydroxytyrosol is a molecule of high interest to the pharmaceutical industry due to its anti-inflammatory and antimicrobial qualities its role against cardiovascular diseases and metabolic syndrome and for its neuroprotection, antitumour, and chemo modulation effects. The interest in this molecule has led to wide research on its biological activities, its beneficial effects in humans and how to synthetize new molecules from hydroxytyrosol.
   This review describes the vast range of information about hydroxytyrosol, focusing on its involvement in biological mechanisms and modulation effects on different pathologies. This review also serves to highlight the role of hydroxytyrosol as a nutraceutical and as a potential therapeutic agent.
C1 [Robles-Almazan, Maria; Ramirez-Tortosa, Cesar] Hosp Complex Jaen, Dept Pathol Anat, Ave Ejercito Espanol 10, Jaen 23007, Spain.
   [Pulido-Moran, Mario; Rodriguez-Garcia, Carmen; Ramirez-Tortosa, MCarmen] Univ Granada, Fac Pharm, Dept Biochem & Mol Biol 2, Univ Campus Cartuja, E-18071 Granada, Spain.
   [Moreno-Fernandez, Jorge] Univ Granada, Fac Pharm, Dept Physiol, Univ Campus Cartuja, E-18071 Granada, Spain.
   [Pulido-Moran, Mario; Moreno-Fernandez, Jorge; Rodriguez-Garcia, Carmen; Quiles, Jose L.; Ramirez-Tortosa, MCarmen] Univ Granada, Biomed Res Ctr, Inst Nutr & Food Technol Jose Mataix, Ave Conocimiento, Granada 18016, Spain.
C3 University of Granada; University of Granada; University of Granada
RP Ramirez-Tortosa, M (corresponding author), Univ Granada, Biomed Res Ctr, Inst Nutr & Food Technol Jose Mataix, Dept Biochem & Mol Biol 2, Granada 18016, Spain.
EM mramirez@ugr.es
RI Moreno-Fernandez, Jorge/L-2793-2017; RoblesAlmazan, Maria/LIC-6578-2024;
   Rodriguez Garcia, Carmen/ACH-8755-2022; Ramírez-Tortosa,
   César/F-2055-2016; Quiles, Jose L./C-6911-2013
OI Quiles, Jose L./0000-0002-9048-9086; Moreno-Fernandez,
   Jorge/0000-0001-9690-7851; Rodriguez Garcia, Carmen/0000-0002-4531-3188
CR Flores MIA, 2012, FOOD CHEM, V134, P2465, DOI 10.1016/j.foodchem.2012.04.058
   Martín MA, 2010, MOL NUTR FOOD RES, V54, P956, DOI 10.1002/mnfr.200900159
   [Anonymous], MEDITERRANEAN DIET E
   [Anonymous], J AGR FOOD CHEM
   Anter J, 2014, MUTAT RES-GEN TOX EN, V772, P25, DOI 10.1016/j.mrgentox.2014.07.002
   Arunsundar M, 2015, NEUROTOX RES, V27, P143, DOI 10.1007/s12640-014-9492-x
   Atzeri A, 2016, FOOD FUNCT, V7, P337, DOI [10.1039/C5FO00074B, 10.1039/c5fo00074b]
   Auñon-Calles D, 2013, PHARMACOL RES, V74, P87, DOI 10.1016/j.phrs.2013.06.002
   Auñon-Calles D, 2013, FOOD CHEM TOXICOL, V55, P498, DOI 10.1016/j.fct.2013.01.030
   Babich H., 2003, Farmaco (Lausanne), V58, P403, DOI 10.1016/S0014-827X(03)00048-X
   Bai C, 1998, J AGR FOOD CHEM, V46, P3998, DOI 10.1021/jf980451r
   Bayram B, 2012, REJUV RES, V15, P71, DOI 10.1089/rej.2011.1245
   Bernini R, 2013, CURR MED CHEM, V20, P655, DOI 10.2174/092986713804999367
   Bernini R, 2017, J AGR FOOD CHEM, V65, P6506, DOI 10.1021/acs.jafc.6b05457
   Bernini R, 2015, J MED CHEM, V58, P9089, DOI 10.1021/acs.jmedchem.5b00669
   Bisignano G, 1999, J PHARM PHARMACOL, V51, P971, DOI 10.1211/0022357991773258
   Bjelakovic G, 2014, CURR OPIN CLIN NUTR, V17, P40, DOI 10.1097/MCO.0000000000000009
   Boskou D., 2008, OLIVE OIL MINOR CONS
   Bouallagui Z, 2011, FOOD CHEM TOXICOL, V49, P179, DOI 10.1016/j.fct.2010.10.014
   Braga PC, 1997, DRUG EXP CLIN RES, V23, P33
   Briante R, 2002, J AGR FOOD CHEM, V50, P4934, DOI 10.1021/jf025540p
   Briante R, 2002, J BIOTECHNOL, V93, P109, DOI 10.1016/S0168-1656(01)00387-X
   Buckland G, 2015, BRIT J NUTR, V113, pS94, DOI 10.1017/S0007114514003936
   Buettner GR, 2006, FREE RADICAL BIO MED, V41, P1338, DOI 10.1016/j.freeradbiomed.2006.07.015
   Burattini S, 2013, FOOD CHEM TOXICOL, V55, P248, DOI 10.1016/j.fct.2012.12.049
   Camargo A, 2010, BMC GENOMICS, V11, DOI 10.1186/1471-2164-11-253
   Cao K, 2014, FREE RADICAL BIO MED, V67, P396, DOI 10.1016/j.freeradbiomed.2013.11.029
   Carluccio MA, 2003, ARTERIOSCL THROM VAS, V23, P622, DOI 10.1161/01.ATV.0000062884.69432.A0
   Catalán U, 2016, MOL NUTR FOOD RES, V60, P2114, DOI 10.1002/mnfr.201600052
   Catalán U, 2015, MOL NUTR FOOD RES, V59, P2523, DOI 10.1002/mnfr.201500361
   Charoenprasert S, 2012, J AGR FOOD CHEM, V60, P7081, DOI 10.1021/jf3017699
   Chashmi NA, 2017, BIOCHEM BIOPH RES CO, V482, P1427, DOI 10.1016/j.bbrc.2016.12.052
   Chaudhry J, 2007, LIFE SCI, V80, P1135, DOI 10.1016/j.lfs.2006.12.004
   Christian MS, 2004, DRUG CHEM TOXICOL, V27, P309, DOI 10.1081/DCT-200039714
   Cicerale S, 2009, CRIT REV FOOD SCI, V49, P218, DOI 10.1080/10408390701856223
   Cooke MS, 2003, FASEB J, V17, P1195, DOI 10.1096/fj.02-0752rev
   Cornier MA, 2008, ENDOCR REV, V29, P777, DOI 10.1210/er.2008-0024
   Corona G, 2009, MOL NUTR FOOD RES, V53, P897, DOI 10.1002/mnfr.200800269
   Couto E, 2011, BRIT J CANCER, V104, P1493, DOI 10.1038/bjc.2011.106
   Covas MI, 2015, BRIT J NUTR, V113, pS19, DOI 10.1017/S0007114515000136
   Crespo MC, 2015, PHARMACOL RES, V95-96, P132, DOI 10.1016/j.phrs.2015.03.018
   Crisante F, 2016, ADV EXP MED BIOL, V901, P25, DOI 10.1007/5584_2015_5013
   D'Angelo S, 2005, FREE RADICAL BIO MED, V38, P908, DOI 10.1016/j.freeradbiomed.2004.12.015
   D'Angelo S, 2001, DRUG METAB DISPOS, V29, P1492
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   de Bock M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057622
   de Bock M, 2013, MOL NUTR FOOD RES, V57, P2079, DOI 10.1002/mnfr.201200795
   de la Torre R, 2006, EUR J NUTR, V45, P307, DOI 10.1007/s00394-006-0596-9
   de Roos B, 2011, EUR J NUTR, V50, P553, DOI 10.1007/s00394-010-0162-3
   Deiana M, 1999, FREE RADICAL BIO MED, V26, P762, DOI 10.1016/S0891-5849(98)00231-7
   Della Ragione F, 2002, FEBS LETT, V532, P289, DOI 10.1016/S0014-5793(02)03683-9
   Dexter DT, 2013, FREE RADICAL BIO MED, V62, P132, DOI 10.1016/j.freeradbiomed.2013.01.018
   Di Tommaso D, 1998, HRC-J HIGH RES CHROM, V21, P549, DOI 10.1002/(SICI)1521-4168(19981001)21:10<549::AID-JHRC549>3.0.CO;2-Z
   Diamanti J, 2014, J AGR FOOD CHEM, V62, P3935, DOI 10.1021/jf405721d
   Domínguez-Perles R, 2017, EUR J NUTR, V56, P215, DOI 10.1007/s00394-015-1071-2
   Estruch R, 2006, ANN INTERN MED, V145, P1, DOI 10.7326/0003-4819-145-1-200607040-00004
   Fabiani R, 2006, J NUTR, V136, P614, DOI 10.1093/jn/136.3.614
   Fabiani R, 2002, EUR J CANCER PREV, V11, P351, DOI 10.1097/00008469-200208000-00006
   Fabiani R, 2016, FOOD FUNCT, V7, P4145, DOI [10.1039/C6FO00958A, 10.1039/c6fo00958a]
   Fabiani R, 2008, J NUTR, V138, P42, DOI 10.1093/jn/138.1.42
   Fabrizio P, 2004, FEBS LETT, V557, P136, DOI 10.1016/S0014-5793(03)01462-5
   Fernández-Avila C, 2015, BIOMED CHROMATOGR, V29, P1035, DOI 10.1002/bmc.3389
   Fernández-Mar MI, 2012, FOOD CHEM, V130, P797, DOI 10.1016/j.foodchem.2011.08.023
   Fitó M, 2008, EUR J CLIN NUTR, V62, P570, DOI 10.1038/sj.ejcn.1602724
   Forman HJ, 2014, FREE RADICAL BIO MED, V66, P24, DOI 10.1016/j.freeradbiomed.2013.05.045
   García A, 2002, EUR FOOD RES TECHNOL, V215, P407, DOI 10.1007/s00217-002-0604-0
   García-Villalba R, 2010, J PHARMACEUT BIOMED, V51, P416, DOI 10.1016/j.jpba.2009.06.021
   Godoy-Caballero MP, 2012, TALANTA, V101, P479, DOI 10.1016/j.talanta.2012.09.063
   Gonçalves I, 2015, SCI REP-UK, V5, DOI 10.1038/srep15524
   Gonzalez-Alonso Adrian, 2015, Rev Esp Geriatr Gerontol, V50, P285, DOI 10.1016/j.regg.2015.05.003
   González-Correa JA, 2008, NEUROSCI LETT, V446, P143, DOI 10.1016/j.neulet.2008.09.022
   González-Santiago M, 2006, ATHEROSCLEROSIS, V188, P35, DOI 10.1016/j.atherosclerosis.2005.10.022
   González-Santiago M, 2010, PHARMACOL RES, V61, P364, DOI 10.1016/j.phrs.2009.12.016
   Goya L, 2007, EUR J NUTR, V46, P70, DOI 10.1007/s00394-006-0633-8
   Granados-Principal S, 2014, BIOCHEM PHARMACOL, V90, P25, DOI 10.1016/j.bcp.2014.04.001
   Granados-Principal S, 2012, MOL NUTR FOOD RES, V56, P733, DOI 10.1002/mnfr.201100703
   Granados-Principal S, 2011, MOL NUTR FOOD RES, V55, pS117, DOI 10.1002/mnfr.201000220
   Granados-Principal S, 2010, NUTR REV, V68, P191, DOI 10.1111/j.1753-4887.2010.00278.x
   Guichard C, 2006, CARCINOGENESIS, V27, P1812, DOI 10.1093/carcin/bgl009
   Gumieniczek A, 2005, EXP TOXICOL PATHOL, V56, P321, DOI 10.1016/j.etp.2004.12.002
   Guo W, 2010, PHYTOTHER RES, V24, P352, DOI 10.1002/ptr.2943
   Hamden K, 2010, FOOD SCI BIOTECHNOL, V19, P439, DOI 10.1007/s10068-010-0062-6
   Han J, 2009, CYTOTECHNOLOGY, V59, P45, DOI 10.1007/s10616-009-9191-2
   Hashimoto T, 2004, FREE RADICAL BIO MED, V36, P555, DOI 10.1016/j.freeradbiomed.2003.12.003
   Heilman J, 2015, FOOD CHEM TOXICOL, V84, P18, DOI 10.1016/j.fct.2015.07.007
   Herrera Acosta E., 2016, PharmaNutrition, V4, P151, DOI 10.1016/j.phanu.2016.10.002
   Hmimed Sara, 2016, PharmaNutrition, V4, P139, DOI 10.1016/j.phanu.2016.09.001
   Hu T, 2014, J AGR FOOD CHEM, V62, P1449, DOI 10.1021/jf405820v
   Jemai H, 2008, CHEM-BIOL INTERACT, V176, P88, DOI 10.1016/j.cbi.2008.08.014
   Kedechi S, 2017, ANDROLOGIA, V49, DOI 10.1111/and.12595
   Khayyal MT, 2002, ARZNEIMITTEL-FORSCH, V52, P797
   Khymenets O, 2016, J FUNCT FOODS, V23, P278, DOI 10.1016/j.jff.2016.02.046
   Khymenets O, 2010, DRUG METAB DISPOS, V38, P1417, DOI 10.1124/dmd.110.032821
   Khymenets O, 2009, OMICS, V13, P7, DOI 10.1089/omi.2008.0079
   Killeen MJ, 2014, DRUG DISCOV TODAY, V19, P373, DOI 10.1016/j.drudis.2013.11.002
   Kirkland D, 2015, MUTAT RES-GEN TOX EN, V777, P17, DOI 10.1016/j.mrgentox.2014.10.012
   Konstantinidou V, 2009, OMICS, V13, P431, DOI 10.1089/omi.2008.0085
   Koo KA, 2006, LIFE SCI, V79, P709, DOI 10.1016/j.lfs.2006.02.019
   Kopel E, 2014, ANN INTERN MED, V161, P157, DOI [10.7326/L14-5014, 10.7326/M13-1725, 10.7326/L14-5014-2]
   Kotronoulas A, 2013, PHARMACOL RES, V77, P47, DOI 10.1016/j.phrs.2013.09.001
   Kyriazis JD, 2013, PHYTOMEDICINE, V20, P275, DOI 10.1016/j.phymed.2012.11.013
   Lee YY, 2016, CHEM RES TOXICOL, V29, P1689, DOI 10.1021/acs.chemrestox.6b00214
   Léger CL, 2005, EUR J CLIN NUTR, V59, P727, DOI 10.1038/sj.ejcn.1602133
   Li JQ, 2012, TOXICOL MECH METHOD, V22, P432, DOI 10.3109/15376516.2012.666659
   Liu ZH, 2015, INT J CLIN EXP PATHO, V8, P3441
   Lopez-Huertas E, 2017, REDOX BIOL, V11, P384, DOI 10.1016/j.redox.2016.12.014
   López-Miranda J, 2010, NUTR METAB CARDIOVAS, V20, P284, DOI 10.1016/j.numecd.2009.12.007
   Luo C, 2013, CURR CANCER DRUG TAR, V13, P625, DOI 10.2174/15680096113139990035
   Maalej A, 2017, BIOMED PHARMACOTHER, V90, P179, DOI 10.1016/j.biopha.2017.03.034
   Manna C, 1999, ADV EXP MED BIOL, V472, P115
   Caderón-Montaño JM, 2013, J AGR FOOD CHEM, V61, P5046, DOI 10.1021/jf400796p
   Martínez-González MA, 2015, PROG CARDIOVASC DIS, V58, P50, DOI 10.1016/j.pcad.2015.04.003
   Mateos R, 2011, FOOD CHEM, V125, P865, DOI 10.1016/j.foodchem.2010.09.054
   Medina E, 2006, J AGR FOOD CHEM, V54, P4954, DOI 10.1021/jf0602267
   Medina-Martínez MS, 2016, BIOSCI BIOTECH BIOCH, V80, P801, DOI 10.1080/09168451.2015.1116924
   Menendez JA, 2007, BMC CANCER, V7, DOI 10.1186/1471-2407-7-80
   Menendez JA, 2006, CURR OPIN CLIN NUTR, V9, P346, DOI 10.1097/01.mco.0000232893.21050.15
   Minuti L, 2006, J CHROMATOGR A, V1114, P263, DOI 10.1016/j.chroma.2006.02.068
   Miro-Casas E, 2003, CLIN CHEM, V49, P945, DOI 10.1373/49.6.945
   MONTEDORO G, 1992, J AGR FOOD CHEM, V40, P1571, DOI 10.1021/jf00021a019
   Mosele JI, 2014, MOL NUTR FOOD RES, V58, P1809, DOI 10.1002/mnfr.201400124
   Mullen GE, 2015, BIOORG MED CHEM LETT, V25, P4363, DOI 10.1016/j.bmcl.2015.08.087
   Muñoz-Marín J, 2012, J AGR FOOD CHEM, V60, P7659, DOI 10.1021/jf3007097
   Nogueira V, 2008, CANCER CELL, V14, P458, DOI 10.1016/j.ccr.2008.11.003
   Notarnicola M, 2011, GENES NUTR, V6, P63, DOI 10.1007/s12263-010-0177-7
   O'Dowd Y, 2004, BIOCHEM PHARMACOL, V68, P2003, DOI 10.1016/j.bcp.2004.06.023
   Ocakoglu D, 2009, FOOD CHEM, V113, P401, DOI 10.1016/j.foodchem.2008.07.057
   Owen R W, 2000, Lancet Oncol, V1, P107, DOI 10.1016/S1470-2045(00)00015-2
   Park G, 2014, SKIN PHARMACOL PHYS, V27, P132, DOI 10.1159/000354917
   Pastor A, 2016, J CHROMATOGR A, V1437, P183, DOI 10.1016/j.chroma.2016.02.016
   Pérez-Bonilla M, 2014, J AGR FOOD CHEM, V62, P144, DOI 10.1021/jf403998t
   Pérez-Mañá C, 2015, PHARMACOL RES, V95-96, P27, DOI 10.1016/j.phrs.2015.02.008
   Poudyal H, 2010, J NUTR, V140, P946, DOI 10.3945/jn.109.117812
   Procopio A, 2009, J AGR FOOD CHEM, V57, P11161, DOI 10.1021/jf9033305
   Quirantes-Piné R, 2013, J PHARMACEUT BIOMED, V72, P121, DOI 10.1016/j.jpba.2012.09.029
   Rafehi H, 2012, GENES NUTR, V7, P343, DOI 10.1007/s12263-011-0249-3
   Rashid A, 1997, AM J PATHOL, V150, P201
   Richard N, 2011, PLANTA MED, V77, P1890, DOI 10.1055/s-0031-1280022
   Rodríguez-Morató J, 2016, DRUG METAB REV, V48, P218, DOI 10.1080/03602532.2016.1179754
   Rodríguez-Morató J, 2015, MOLECULES, V20, P4655, DOI 10.3390/molecules20034655
   Romero C, 2004, J AGR FOOD CHEM, V52, P479, DOI 10.1021/jf030525l
   Roowi S, 2009, MOL NUTR FOOD RES, V53, pS68, DOI 10.1002/mnfr.200800287
   Rosignoli P, 2016, FOOD FUNCT, V7, P301, DOI [10.1039/c5fo00932d, 10.1039/C5FO00932D]
   Rubió L, 2014, FOOD RES INT, V65, P59, DOI 10.1016/j.foodres.2014.05.009
   Rubió L, 2012, FOOD CHEM, V135, P2922, DOI 10.1016/j.foodchem.2012.07.085
   Salucci S, 2014, J PHOTOCH PHOTOBIO B, V141, P1, DOI 10.1016/j.jphotobiol.2014.09.004
   Sarsour EH, 2012, AGE, V34, P95, DOI 10.1007/s11357-011-9223-7
   Schaffer S, 2007, J AGR FOOD CHEM, V55, P5043, DOI 10.1021/jf0703710
   Schaffer S, 2010, PHARMACOL RES, V62, P322, DOI 10.1016/j.phrs.2010.06.004
   Sclip A, 2011, J BIOL CHEM, V286, P43871, DOI 10.1074/jbc.M111.297515
   Scoditti E, 2014, ATHEROSCLEROSIS, V232, P17, DOI 10.1016/j.atherosclerosis.2013.10.017
   Serra A, 2012, MOL NUTR FOOD RES, V56, P486, DOI 10.1002/mnfr.201100436
   Servili M, 2004, J CHROMATOGR A, V1054, P113, DOI 10.1016/S0021-9673(04)01423-2
   Soni MG, 2006, FOOD CHEM TOXICOL, V44, P903, DOI 10.1016/j.fct.2006.01.008
   Suárez M, 2011, BRIT J NUTR, V106, P1691, DOI 10.1017/S0007114511002200
   Sun LJ, 2014, FOOD FUNCT, V5, P1909, DOI 10.1039/c4fo00187g
   Tasset I, 2011, NUTR NEUROSCI, V14, P106, DOI 10.1179/1476830511Y.0000000005
   Terzuoli E, 2016, MOL NUTR FOOD RES, V60, P519, DOI 10.1002/mnfr.201500498
   Toteda G, 2017, J ENDOCRINOL INVEST, V40, P153, DOI 10.1007/s40618-016-0537-2
   Trujillo M, 2014, J AGR FOOD CHEM, V62, P10297, DOI 10.1021/jf503543x
   Tuck KL, 2001, J NUTR, V131, P1993, DOI 10.1093/jn/131.7.1993
   Tutino V, 2012, ANTICANCER RES, V32, P5371
   Varela-Lopez A, 2016, J GERONTOL A-BIOL, V71, P593, DOI 10.1093/gerona/glv063
   Vilaplana-Perez Cristina, 2014, Front Nutr, V1, P18, DOI 10.3389/fnut.2014.00018
   Visioli F, 2003, J NUTR, V133, P2612, DOI 10.1093/jn/133.8.2612
   Visioli F, 1998, BIOCHEM BIOPH RES CO, V247, P60, DOI 10.1006/bbrc.1998.8735
   Visioli Francesco, 2015, PharmaNutrition, V3, P60, DOI 10.1016/j.phanu.2015.04.001
   Vissers MN, 2002, J NUTR, V132, P409, DOI 10.1093/jn/132.3.409
   Wang Y, 2001, CLIN CHIM ACTA, V304, P107, DOI 10.1016/S0009-8981(00)00404-6
   Warleta F, 2011, NUTRIENTS, V3, P839, DOI 10.3390/nu3100839
   Zhang XM, 2009, N-S ARCH PHARMACOL, V379, P581, DOI 10.1007/s00210-009-0399-7
   Zhang XM, 2008, CHEM-BIOL INTERACT, V176, P173, DOI 10.1016/j.cbi.2008.08.002
   Zheng A, 2015, BRIT J NUTR, V113, P1667, DOI 10.1017/S0007114515000884
   Zheng A, 2015, J NUTR BIOCHEM, V26, P190, DOI 10.1016/j.jnutbio.2014.10.006
   Zhu L, 2010, J NUTR BIOCHEM, V21, P1089, DOI 10.1016/j.jnutbio.2009.09.006
   Zoric N, 2013, CURR DRUG TARGETS, V14, P992, DOI 10.2174/13894501113149990167
   Zou X, 2012, J NUTR BIOCHEM, V23, P994, DOI 10.1016/j.jnutbio.2011.05.006
   Zrelli H, 2011, J AGR FOOD CHEM, V59, P4473, DOI 10.1021/jf104151d
   Zwane RE, 2012, J AGR FOOD CHEM, V60, P11509, DOI 10.1021/jf300883h
NR 179
TC 236
Z9 246
U1 12
U2 179
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0963-9969
EI 1873-7145
J9 FOOD RES INT
JI Food Res. Int.
PD MAR
PY 2018
VL 105
BP 654
EP 667
DI 10.1016/j.foodres.2017.11.053
PG 14
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA FW8GJ
UT WOS:000425567900068
PM 29433260
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Tana, C
   Tafuri, E
   Tana, M
   Martelletti, P
   Negro, A
   Affaitati, G
   Fabrizio, A
   Costantini, R
   Mezzetti, A
   Giamberardino, MA
AF Tana, Claudio
   Tafuri, Emmanuele
   Tana, Marco
   Martelletti, Paolo
   Negro, Andrea
   Affaitati, Giannapia
   Fabrizio, Alessandra
   Costantini, Raffaele
   Mezzetti, Andrea
   Giamberardino, Maria Adele
TI New insights into the cardiovascular risk of migraine and the role of
   white matter hyperintensities: is gold all that glitters?
SO JOURNAL OF HEADACHE AND PAIN
LA English
DT Review
DE Migraine; Cardiovascular events; Risk factors
ID ENDOTHELIAL PROGENITOR CELLS; TENSION-TYPE HEADACHE; SMALL VESSEL
   DISEASE; N-ACETYL-ASPARTATE; OXIDATIVE STRESS; ISCHEMIC-STROKE;
   METABOLIC SYNDROME; BRAIN-LESIONS; YOUNG-WOMEN; MRI
AB The role of migraine as an independent risk factor for cardiovascular events has been debated for several years, while it is more established for ischemic stroke. Recently, new studies have examined the likelihood of migraine to determine cardiovascular events, supporting the hypothesis of a predominant role in patients with migraine with aura, the risk including both sexes. In the literature, multiple pathophysiological mechanisms are described to explain this association, and are here discussed. Furthermore, the emerging evidence that a higher headache frequency and long-term migraine may worsen the cardio-metabolic profile in migraineurs (e. g. with a higher Framingham risk score and risk of developing atherosclerosis, insulin resistance and metabolic syndrome) makes it increasingly necessary to reduce the number and severity of attacks, not only to alleviate the painful symptoms, but also to improve the prognosis in these patients.
C1 [Tana, Claudio; Tafuri, Emmanuele; Tana, Marco; Affaitati, Giannapia; Fabrizio, Alessandra; Mezzetti, Andrea; Giamberardino, Maria Adele] Univ G dAnnunzio, Dept Med, Chieti, Italy.
   [Tana, Claudio; Tafuri, Emmanuele; Tana, Marco; Affaitati, Giannapia; Fabrizio, Alessandra; Mezzetti, Andrea; Giamberardino, Maria Adele] Univ G dAnnunzio, Ctr Excellence Aging, Chieti, Italy.
   [Tana, Claudio; Tafuri, Emmanuele; Fabrizio, Alessandra; Giamberardino, Maria Adele] SS Annunziata Hosp, Ctr Excellence Headache, Chieti, Italy.
   [Martelletti, Paolo; Negro, Andrea] Univ Roma La Sapienza, St Andrea Hosp, Reg Referral Headache Ctr, Dept Clin & Mol Med, Rome, Italy.
   [Costantini, Raffaele] Univ G DAnnunzio, Inst Surg Pathol, Chieti, Italy.
C3 G d'Annunzio University of Chieti-Pescara; G d'Annunzio University of
   Chieti-Pescara; Sapienza University Rome; Azienda Ospedaliera
   Sant'Andrea; G d'Annunzio University of Chieti-Pescara
RP Giamberardino, MA (corresponding author), Via Carlo de Tocco 3, I-66100 Chieti, Italy.
EM mag@unich.it
RI Tana, Marco/LOR-6880-2024; Tana, Claudio/L-5576-2019
OI Tana, Claudio/0000-0002-9162-7866; Martelletti,
   Paolo/0000-0002-6556-4128; Tana, Marco/0000-0002-0899-9870; Negro,
   Andrea/0000-0003-3590-298X
FU "G. D'Annunzio" University Funds
FX This study was supported by "G. D'Annunzio" University Funds for
   research to Maria Adele Giamberardino.
CR Baars MAE, 2010, HEADACHE, V50, P176, DOI 10.1111/j.1526-4610.2009.01572.x
   Baezner H, 2008, NEUROLOGY, V70, P935, DOI 10.1212/01.wnl.0000305959.46197.e6
   BENSON MD, 1986, J REPROD MED, V31, P1082
   Bernecker C, 2011, EUR J NEUROL, V18, P1233, DOI 10.1111/j.1468-1331.2011.03414.x
   Bernecker C, 2010, CEPHALALGIA, V30, P1366, DOI 10.1177/0333102410364674
   Besir FH, 2013, PAIN PRACT, V13, P41, DOI 10.1111/j.1533-2500.2012.00551.x
   Bhoi SK, 2012, J HEADACHE PAIN, V13, P321, DOI 10.1007/s10194-012-0416-y
   Bigal ME, 2010, NEUROLOGY, V74, P628, DOI 10.1212/WNL.0b013e3181d0cc8b
   Bigal ME, 2009, NEUROLOGY, V72, P1864, DOI 10.1212/WNL.0b013e3181a71220
   Bigal ME, 2006, NEUROLOGY, V66, P545, DOI 10.1212/01.wnl.0000197218.05284.82
   Cavestro C, 2007, HEADACHE, V47, P1436, DOI 10.1111/j.1526-4610.2007.00719.x
   Chang CL, 1999, BMJ-BRIT MED J, V318, P13
   Cohen Jessica I, 2011, Neuroradiol J, V1, P989
   Colombo B, 2011, NEUROL SCI, V32, pS37, DOI 10.1007/s10072-011-0530-7
   DAWBER TR, 1959, AM J PUBLIC HEALTH N, V49, P1349, DOI 10.2105/AJPH.49.10.1349
   de Tommaso M, 2012, J HEADACHE PAIN, V13, P389, DOI 10.1007/s10194-012-0448-3
   Debette S, 2010, BMJ-BRIT MED J, V341, DOI 10.1136/bmj.c3666
   Dinia L, 2013, J NEUROIMAGING, V23, P47, DOI 10.1111/j.1552-6569.2011.00643.x
   Etminan M, 2005, BMJ-BRIT MED J, V330, P63, DOI 10.1136/bmj.38302.504063.8F
   FAZEKAS F, 1992, HEADACHE, V32, P287, DOI 10.1111/j.1526-4610.1992.hed3206287.x
   Greenland P, 2010, J AM COLL CARDIOL, V56, pE50, DOI 10.1016/j.jacc.2010.09.001
   Gruber HJ, 2010, CEPHALALGIA, V30, P593, DOI 10.1111/j.1468-2982.2009.02012.x
   Gudmundsson LS, 2010, BMJ-BRIT MED J, V341, DOI 10.1136/bmj.c3966
   Guldiken B, 2009, NEUROLOGIST, V15, P55, DOI 10.1097/NRL.0b013e31817781b6
   Gupta R, 2009, ANN INDIAN ACAD NEUR, V12, P167, DOI 10.4103/0972-2327.56316
   Hamed SA, 2010, J STROKE CEREBROVASC, V19, P92, DOI 10.1016/j.jstrokecerebrovasdis.2009.04.007
   Hyttinen L, 2009, ACTA RADIOL, V50, P320, DOI 10.1080/02841850802709227
   Knopman DS, 2011, NEUROLOGY, V76, P1879, DOI 10.1212/WNL.0b013e31821d753f
   Kruit MC, 2010, CEPHALALGIA, V30, P129, DOI 10.1111/j.1468-2982.2009.01904.x
   Kruit MC, 2006, STROKE, V37, P1109, DOI 10.1161/01.STR.0000206446.26702.e9
   Kruit MC, 2004, JAMA-J AM MED ASSOC, V291, P427, DOI 10.1001/jama.291.4.427
   Kuchel GA, 2009, J GERONTOL A-BIOL, V64, P902, DOI 10.1093/gerona/glp037
   Kurth T, 2007, ARCH INTERN MED, V167, P795, DOI 10.1001/archinte.167.8.795
   Kurth T, 2011, CEPHALALGIA, V31, P1106, DOI 10.1177/0333102411412628
   Kurth T, 2011, BMJ-BRIT MED J, V342, DOI 10.1136/bmj.c7357
   Kurth T, 2006, JAMA-J AM MED ASSOC, V296, P283, DOI 10.1001/jama.296.3.283
   Lee ST, 2008, NEUROLOGY, V70, P1510, DOI 10.1212/01.wnl.0000294329.93565.94
   Lionetto L, 2012, EXPERT REV NEUROTHER, V12, P1057, DOI [10.1586/ERN.12.97, 10.1586/ern.12.97]
   Mikirova NA, 2009, J TRANSL MED, V7, DOI 10.1186/1479-5876-7-106
   Mok VCT, 2004, J NEUROL NEUROSUR PS, V75, P560, DOI 10.1136/jnnp.2003.015107
   Negro A, 2010, INTERN EMERG MED, V5, pS13, DOI 10.1007/s11739-010-0457-7
   Olesen PJ, 2010, NEUROPSYCHOPHARMACOL, V35, P2638, DOI 10.1038/npp.2010.176
   PAVESE N, 1994, CEPHALALGIA, V14, P342, DOI 10.1046/j.1468-2982.1994.1405342.x
   Perk J, 2012, EUR HEART J, V33, P1635, DOI 10.1093/eurheartj/ehs092
   Rainero I, 2005, CEPHALALGIA, V25, P593, DOI 10.1111/j.1468-2982.2005.00928.x
   Redberg RF, 2009, J AM COLL CARDIOL, V54, P1364, DOI 10.1016/j.jacc.2009.08.005
   Rist PM, 2011, CEPHALALGIA, V31, P1459, DOI 10.1177/0333102411421682
   Rodríguez-Osorio X, 2012, NEUROLOGY, V79, P474, DOI 10.1212/WNL.0b013e31826170ce
   Rose KM, 2007, NEUROLOGY, V68, P1694, DOI 10.1212/01.wnl.0000261916.42871.05
   Scher AI, 2003, PAIN, V106, P81, DOI 10.1016/S0304-3959(03)00293-8
   Scher AI, 2005, NEUROLOGY, V64, P614, DOI 10.1212/01.WNL.0000151857.43225.49
   Schmitz N, 2008, HEADACHE, V48, P1044, DOI 10.1111/j.1526-4610.2008.01133.x
   Schürks M, 2011, CEPHALALGIA, V31, P1301, DOI 10.1177/0333102411415879
   Schürks M, 2009, BMJ-BRIT MED J, V339, DOI 10.1136/bmj.b3914
   Schwaiger J, 2008, NEUROLOGY, V71, P937, DOI 10.1212/01.wnl.0000325918.48056.75
   Serafini G, 2012, J HEADACHE PAIN, V13, P661, DOI 10.1007/s10194-012-0493-y
   SHIMOMURA T, 1994, CEPHALALGIA, V14, P215, DOI 10.1046/j.1468-2982.1994.014003215.x
   Sibal L, 2011, DIABET METAB SYND OB, V4, P23, DOI 10.2147/DMSO.S8540
   Silbert LC, 2008, NEUROLOGY, V71, P108, DOI 10.1212/01.wnl.0000316799.86917.37
   Tadic SD, 2010, NEUROIMAGE, V51, P1294, DOI 10.1016/j.neuroimage.2010.03.016
   Taffi R, 2005, CEPHALALGIA, V25, P353, DOI 10.1111/j.1468-2982.2004.00863.x
   Tana C, 2012, J HEADACHE PAIN, V13, pS47
   Trauninger A, 2011, J HEADACHE PAIN, V12, P97, DOI 10.1007/s10194-011-0299-3
   Tuncel D, 2008, BIOL TRACE ELEM RES, V126, P92, DOI 10.1007/s12011-008-8193-9
   TZOURIO C, 1993, BMJ-BRIT MED J, V307, P289, DOI 10.1136/bmj.307.6899.289
   TZOURIO C, 1995, BMJ-BRIT MED J, V310, P830, DOI 10.1136/bmj.310.6983.830
   Uzar E, 2011, EUR REV MED PHARMACO, V15, P1111
   Uzar E, 2011, J HEADACHE PAIN, V12, P239, DOI 10.1007/s10194-011-0323-7
   van der Flier WM, 2005, STROKE, V36, P2116, DOI 10.1161/01.STR.0000179092.59909.42
   Vattakatuchery JJ, 2010, BRIT MED J, V341, DOI 10.1136/bmj.c4611
   Vuorinen M, 2011, DEMENT GERIATR COGN, V31, P119, DOI 10.1159/000323810
   Winsvold BS, 2011, EUR J NEUROL, V18, P504, DOI 10.1111/j.1468-1331.2010.03199.x
   Winter AC, 2009, CEPHALALGIA, V29, P269, DOI 10.1111/j.1468-2982.2008.01716.x
   Xiong Yun Yun, 2011, J Aging Res, V2011, P617927, DOI 10.4061/2011/617927
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
NR 75
TC 49
Z9 49
U1 0
U2 31
PU SPRINGEROPEN
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 1129-2369
EI 1129-2377
J9 J HEADACHE PAIN
JI J. Headache Pain
PY 2013
VL 14
AR 9
DI 10.1186/1129-2377-14-9
PG 9
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 130MD
UT WOS:000317920400009
PM 23565964
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cheung, O
   Sanyal, AJ
AF Cheung, Onpan
   Sanyal, Arun J.
TI Abnormalities of Lipid Metabolism in Nonalcoholic Fatty Liver Disease
SO SEMINARS IN LIVER DISEASE
LA English
DT Review
DE Nonalcoholic steatohepatitis; metabolic syndrome; insulin resistance; de
   novo lipogenesis; hepatic steatosis
ID ACTIVATED-RECEPTOR-ALPHA; ELEMENT-BINDING-PROTEIN; TRIGLYCERIDE TRANSFER
   PROTEIN; ENDOPLASMIC-RETICULUM STRESS; IMPROVES HEPATIC STEATOSIS;
   GENE-EXPRESSION; INSULIN-RESISTANCE; MITOCHONDRIAL DYSFUNCTION;
   BETA-OXIDATION; PPAR-GAMMA
AB Nonalcoholic fatty liver disease (NAFLD) is the most common liver abnormality in the United States and is strongly associated with the metabolic syndrome. Although many of the risk factors are well defined, the pathogenesis of NAFLD remains poorly understood. Recent studies have implicated several important cellular processes and signaling pathways that are affected by abnormal lipid metabolism, resulting in specific biochemical, histological, and clinical changes associated with NAFLD. Pharmacotherapy for NAFLD is limited and treatments are mainly to minimize risk factors. Understanding the disease pathogenesis is therefore important in identifying individuals with increased susceptibility for disease progression so lifestyle and risk modifications can be initiated early on. In this review, recent advances in the study of abnormal lipid metabolism and its impacts on histology and dysregulation of various cellular processes implicated in the genesis of NAFLD will be discussed.
C1 [Cheung, Onpan; Sanyal, Arun J.] Virginia Commonwealth Univ, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, Med Ctr, Richmond, VA USA.
C3 Virginia Commonwealth University
RP Sanyal, AJ (corresponding author), MCV Box 980341, Richmond, VA 23298 USA.
EM ajsanyal@hsc.vcu.edu
CR Adams LA, 2005, J HEPATOL, V42, P132, DOI 10.1016/j.jhep.2004.09.012
   Alvarez-Garcia I, 2005, DEVELOPMENT, V132, P4653, DOI 10.1242/dev.02073
   Ambros V, 2004, NATURE, V431, P350, DOI 10.1038/nature02871
   Araya J, 2004, CLIN SCI, V106, P635, DOI 10.1042/CS20030326
   Asayama K, 1999, MOL CELL BIOCHEM, V194, P227, DOI 10.1023/A:1006930513476
   Azzout-Marniche D, 2000, BIOCHEM J, V350, P389, DOI 10.1042/0264-6021:3500389
   Begriche K, 2006, MITOCHONDRION, V6, P1, DOI 10.1016/j.mito.2005.10.004
   Bernard S, 2000, DIABETOLOGIA, V43, P995, DOI 10.1007/s001250051481
   Browning JD, 2004, HEPATOLOGY, V40, P1387, DOI 10.1002/hep.20466
   Browning JD, 2004, J CLIN INVEST, V114, P147, DOI 10.1172/JCI200422422
   Brunt EM, 2001, SEMIN LIVER DIS, V21, P3, DOI 10.1055/s-2001-12925
   Bugianesi E, 2002, GASTROENTEROLOGY, V123, P134, DOI 10.1053/gast.2002.34168
   Cha JY, 2007, J BIOL CHEM, V282, P743, DOI 10.1074/jbc.M605023200
   Chalasani N, 2003, HEPATOLOGY, V37, P544, DOI 10.1053/jhep.2003.50095
   Cheung O, 2007, HEPATOLOGY, V46, P1091, DOI 10.1002/hep.21803
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Curat CA, 2006, DIABETOLOGIA, V49, P744, DOI 10.1007/s00125-006-0173-z
   de Pablo MA, 2000, IMMUNOL CELL BIOL, V78, P31, DOI 10.1046/j.1440-1711.2000.00875.x
   Dentin R, 2006, DIABETES, V55, P2159, DOI 10.2337/db06-0200
   DESPRES JP, 1993, NUTRITION, V9, P452
   Diehl AM, 2005, GUT, V54, P303, DOI 10.1136/gut.2003.024935
   Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI23621
   EKSTROM G, 1989, BIOCHEM PHARMACOL, V38, P1313, DOI 10.1016/0006-2952(89)90338-9
   Esau C, 2006, CELL METAB, V3, P87, DOI 10.1016/j.cmet.2006.01.005
   Esau C, 2004, J BIOL CHEM, V279, P52361, DOI 10.1074/jbc.C400438200
   Evans RM, 2004, NAT MED, V10, P355, DOI 10.1038/nm1025
   Fan CY, 1998, J BIOL CHEM, V273, P15639, DOI 10.1074/jbc.273.25.15639
   Feldstein AE, 2004, HEPATOLOGY, V40, P185, DOI 10.1002/hep.20283
   Fleischmann M, 2000, BIOCHEM J, V349, P13, DOI 10.1042/0264-6021:3490013
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gambino R, 2007, HEPATOLOGY, V45, P1097, DOI 10.1002/hep.21631
   GOLAY A, 1990, J CLIN ENDOCR METAB, V71, P1299, DOI 10.1210/jcem-71-5-1299
   Gu Nan, 2007, Zhonghua Yixue Yichuanxue Zazhi, V24, P251
   Harano Y, 2006, LIVER INT, V26, P613, DOI 10.1111/j.1478-3231.2006.01265.x
   Hashimoto T, 2000, J BIOL CHEM, V275, P28918, DOI 10.1074/jbc.M910350199
   Hensley K, 2000, CARCINOGENESIS, V21, P983, DOI 10.1093/carcin/21.5.983
   Herruzo JAS, 2006, REV ESP ENFERM DIG, V98, P844
   Hsiao PJ, 2007, J GASTROEN HEPATOL, V22, P2118, DOI 10.1111/j.1440-1746.2006.04698.x
   Iizuka K, 2004, P NATL ACAD SCI USA, V101, P7281, DOI 10.1073/pnas.0401516101
   Ip E, 2003, HEPATOLOGY, V38, P123, DOI 10.1053/jhep.2003.50307
   Ishii S, 2004, P NATL ACAD SCI USA, V101, P15597, DOI 10.1073/pnas.0405238101
   JAMES WP, 2003, WHO COMP QUANTIFICAT, V1
   Jopling CL, 2006, COLD SPRING HARB SYM, V71, P369, DOI 10.1101/sqb.2006.71.022
   Kashireddy PV, 2004, HEPATOL RES, V30, P104, DOI 10.1016/j.hepres.2004.06.004
   KAYE SA, 1991, J CLIN EPIDEMIOL, V44, P329, DOI 10.1016/0895-4356(91)90044-A
   Kohjima M, 2007, INT J MOL MED, V20, P351
   Krützfeldt J, 2005, NATURE, V438, P685, DOI 10.1038/nature04303
   Kukoba T V, 2005, Fiziol Zh, V51, P26
   Li JP, 2002, AM J PHYSIOL-ENDOC M, V282, pE1334, DOI 10.1152/ajpendo.00516.2001
   Listenberger LL, 2003, P NATL ACAD SCI USA, V100, P3077, DOI 10.1073/pnas.0630588100
   Magana MM, 1997, J LIPID RES, V38, P1630
   Malhi H, 2006, J BIOL CHEM, V281, P12093, DOI 10.1074/jbc.M510660200
   Mater MK, 1999, J BIOL CHEM, V274, P32725, DOI 10.1074/jbc.274.46.32725
   Matsusue K, 2003, J CLIN INVEST, V111, P737, DOI 10.1172/JCI200317223
   Mitro N, 2007, NATURE, V445, P219, DOI 10.1038/nature05449
   Nakamuta M, 2005, INT J MOL MED, V16, P631
   Namikawa C, 2004, J HEPATOL, V40, P781, DOI 10.1016/j.jhep.2004.01.028
   Nilsen TW, 2007, TRENDS GENET, V23, P243, DOI 10.1016/j.tig.2007.02.011
   Ort T, 2005, ENDOCRINOLOGY, V146, P2200, DOI 10.1210/en.2004-1421
   Osei-Hyiaman D, 2005, J CLIN INVEST, V115, P1298, DOI 10.1172/JCI200523057
   Paradies G, 2002, GENE, V286, P135, DOI 10.1016/S0378-1119(01)00814-9
   Pessayre D, 2002, AM J PHYSIOL-GASTR L, V282, pG193, DOI 10.1152/ajpgi.00426.2001
   Petrosillo G, 2007, BBA-BIOENERGETICS, V1767, P1260, DOI 10.1016/j.bbabio.2007.07.011
   Poy MN, 2004, NATURE, V432, P226, DOI 10.1038/nature03076
   Prunet-Marcassus B, 2006, EXP CELL RES, V312, P727, DOI 10.1016/j.yexcr.2005.11.021
   Puri P, 2006, HEPATOLOGY, V44, p213A
   Puri P, 2007, HEPATOLOGY, V46, P1081, DOI 10.1002/hep.21763
   Rae C, 2007, FEBS LETT, V581, P4877, DOI 10.1016/j.febslet.2007.09.014
   Rao MS, 2004, HEPATOLOGY, V40, P783, DOI 10.1002/hep.20453
   Reddy JK, 2001, ANNU REV NUTR, V21, P193, DOI 10.1146/annurev.nutr.21.1.193
   Ren DL, 2002, GENE DEV, V16, P27, DOI 10.1101/gad.953802
   Ribot J, 2001, PFLUG ARCH EUR J PHY, V441, P498, DOI 10.1007/s004240000454
   Sanyal AJ, 2001, GASTROENTEROLOGY, V120, P1183, DOI 10.1053/gast.2001.23256
   Sanyal Arun J, 2002, Gastroenterology, V123, P1705, DOI 10.1053/gast.2002.36572
   Savage DB, 2006, J CLIN INVEST, V116, P817, DOI 10.1172/JCI27300
   Schattenberg JRM, 2005, J BIOL CHEM, V280, P9887, DOI 10.1074/jbc.M410310200
   Sekiya M, 2003, HEPATOLOGY, V38, P1529, DOI 10.1016/j.hep.2003.09.028
   Seo YS, 2008, J GASTROEN HEPATOL, V23, P102, DOI 10.1111/j.1440-1746.2006.04819.x
   Siegmund SV, 2005, HEPATOLOGY, V41, P1085, DOI 10.1002/hep.20667
   Sreekumar R, 2003, HEPATOLOGY, V38, P244, DOI 10.1053/jhep.2003.50290
   Sweeney B, 2005, PEDIATR SURG INT, V21, P335, DOI 10.1007/s00383-005-1385-x
   Thompson BJ, 2006, CELL, V126, P767, DOI 10.1016/j.cell.2006.07.013
   Unger RH, 2002, ANNU REV MED, V53, P319, DOI 10.1146/annurev.med.53.082901.104057
   VidalPuig AJ, 1997, J CLIN INVEST, V99, P2416, DOI 10.1172/JCI119424
   Wang D, 2006, ENDOCRINOLOGY, V147, P943, DOI 10.1210/en.2005-0570
   Wei YR, 2006, AM J PHYSIOL-ENDOC M, V291, pE275, DOI 10.1152/ajpendo.00644.2005
   Weltman MD, 1996, GASTROENTEROLOGY, V111, P1645, DOI 10.1016/S0016-5085(96)70028-8
   Werman A, 1997, J BIOL CHEM, V272, P20230, DOI 10.1074/jbc.272.32.20230
   Yamashita H, 2001, P NATL ACAD SCI USA, V98, P9116, DOI 10.1073/pnas.161284298
   Yang Z, 2007, PEDIATR INT, V49, P883, DOI 10.1111/j.1442-200X.2007.02478.x
   Yin HY, 2005, ANTIOXID REDOX SIGN, V7, P170, DOI 10.1089/ars.2005.7.170
   Younossi ZM, 2005, LIVER INT, V25, P760, DOI 10.1111/j.1478-3231.2005.01117.x
   Yu ST, 2003, J BIOL CHEM, V278, P498, DOI 10.1074/jbc.M210062200
   Yu XX, 2005, HEPATOLOGY, V42, P362, DOI 10.1002/hep.20783
   Zhang YL, 2006, J BIOL CHEM, V281, P37603, DOI 10.1074/jbc.M604709200
NR 95
TC 87
Z9 101
U1 2
U2 24
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0272-8087
EI 1098-8971
J9 SEMIN LIVER DIS
JI Semin. Liver Dis.
PD NOV
PY 2008
VL 28
IS 4
BP 351
EP 359
DI 10.1055/s-0028-1091979
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 370RG
UT WOS:000260779800003
PM 18956291
DA 2025-06-11
ER

PT J
AU Puttonen, S
   Härmä, M
   Hublin, C
AF Puttonen, Sampsa
   Harma, Mikko
   Hublin, Christer
TI Shift work and cardiovascular disease - pathways from circadian stress
   to morbidity
SO SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH
LA English
DT Review
DE CHD; coronary heart disease; CHD; CVD; literature review; working hour
ID CORONARY-HEART-DISEASE; MALE JAPANESE WORKERS; AMBULATORY
   BLOOD-PRESSURE; MALE FACTORY-WORKERS; BODY-MASS INDEX; METABOLIC
   SYNDROME; SLEEP DURATION; RISK-FACTORS; FOLLOW-UP; RATE-VARIABILITY
AB In order to establish a causal relation between shift work and cardiovascular disease (CVD), we need to verify the pathways front the former to the latter. This paper aims to review the Current knowledge of the mechanisms between shift work and CVD. Shift work can increase the risk of CVD by several interrelated psychosocial, behavioral, and physiological mechanisms. The psychosocial mechanisms relate to difficulties in controlling working hours, decreased work life balance, and poor recovery following work. The most probable behavioral changes are weight gain and smoking. The plausible physiological and biological mechanisms are related to the activation of the autonomic nervous System, inflammation, changed lipid and glucose metabolism, and related changes in the risk for atherosclerosis, metabolic syndrome, and type 11 diabetes. The data provide evidence for possible disease mechanisms between shift work and CVD, but compelling evidence on any specific mechanism is missing.
C1 [Puttonen, Sampsa] Finnish Inst Occupat Hlth, Ctr Expertise Human Factors Work, FI-00250 Helsinki, Finland.
C3 Finnish Institute of Occupational Health
RP Puttonen, S (corresponding author), Finnish Inst Occupat Hlth, Ctr Expertise Human Factors Work, Topeliuksenkatu 41A A, FI-00250 Helsinki, Finland.
EM sampsa.puttonen@ttl.fi
RI Hublin, Christer/AAM-7105-2021
OI Puttonen, Sampsa/0000-0002-7796-6941
CR Adameova A, 2009, CAN J PHYSIOL PHARM, V87, P493, DOI [10.1139/Y09-042, 10.1139/y09-042]
   Åkerstedt T, 2003, OCCUP MED-OXFORD, V53, P89, DOI 10.1093/occmed/kqg046
   Åkerstedt T, 2008, CHRONOBIOL INT, V25, P333, DOI 10.1080/07420520802113922
   Ala-Mursala L, 2002, J EPIDEMIOL COMMUN H, V56, P272, DOI 10.1136/jech.56.4.272
   Ala-Mursula L, 2004, OCCUP ENVIRON MED, V61, P254, DOI 10.1136/oem.2002.005983
   Albertsen K, 2008, SCAND J WORK ENV HEA, P14
   American Academy of Sleep Medicine, 2005, ICSD 2 INT CLASS SLE
   Amir O, 2004, AM J CARDIOL, V93, P947, DOI 10.1016/j.amjcard.2003.12.032
   Antoniades C, 2009, EUR HEART J, V30, P6, DOI 10.1093/eurheartj/ehn515
   Ayas NT, 2003, ARCH INTERN MED, V163, P205, DOI 10.1001/archinte.163.2.205
   Biggi N, 2008, CHRONOBIOL INT, V25, P443, DOI 10.1080/07420520802114193
   Boggild H, 1999, SCAND J WORK ENV HEA, V25, P85, DOI 10.5271/sjweh.410
   Boggild H, 2001, SCAND J WORK ENV HEA, V27, P87, DOI 10.5271/sjweh.594
   Boggild H, 2001, SCAND J WORK ENV HEA, V27, P97, DOI 10.5271/sjweh.595
   Boggild H, 2009, SCAND J WORK ENV HEA, V35, P157, DOI 10.5271/sjweh.1330
   Bonde JP, 2009, J OCCUP ENVIRON MED, V51, P732, DOI 10.1097/JOM.0b013e3181a826f6
   BOOGAARD PJ, 1994, OCCUP ENVIRON MED, V51, P638, DOI 10.1136/oem.51.9.638
   Boucsein W, 1996, BIOL PSYCHOL, V42, P301, DOI 10.1016/0301-0511(95)05164-3
   Cappuccio FP, 2008, SLEEP, V31, P619, DOI 10.1093/sleep/31.5.619
   Chung MH, 2009, SCAND J WORK ENV HEA, V35, P180, DOI 10.5271/sjweh.1324
   Copertaro A, 2008, EUR J CARDIOV PREV R, V15, P224, DOI 10.1097/HJR.0b013e3282f364c0
   Costa G, 2006, CHRONOBIOL INT, V23, P1125, DOI 10.1080/07420520601087491
   Curti R, 1982, Med Lav, V73, P564
   Danesh J, 2000, BMJ-BRIT MED J, V321, P199, DOI 10.1136/bmj.321.7255.199
   De Bacquer D, 2009, INT J EPIDEMIOL, V38, P848, DOI 10.1093/ije/dyn360
   Di Lorenzo L, 2003, INT J OBESITY, V27, P1353, DOI 10.1038/sj.ijo.0802419
   Dochi M, 2009, OCCUP ENVIRON MED, V66, P592, DOI 10.1136/oem.2008.042176
   Drake CL, 2004, SLEEP, V27, P1453, DOI 10.1093/sleep/27.8.1453
   Driscoll TR, 2007, SLEEP MED REV, V11, P179, DOI 10.1016/j.smrv.2006.11.001
   EAKER ED, 1992, AM J EPIDEMIOL, V135, P854, DOI 10.1093/oxfordjournals.aje.a116381
   Eller NH, 2009, CARDIOL REV, V17, P83, DOI 10.1097/CRD.0b013e318198c8e9
   Esquirol Y, 2009, CHRONOBIOL INT, V26, P544, DOI 10.1080/07420520902821176
   Fialho G, 2006, AM J HYPERTENS, V19, P1005, DOI 10.1016/j.amjhyper.2006.03.007
   Frost P, 2009, SCAND J WORK ENV HEA, V35, P163, DOI 10.5271/sjweh.1319
   Fujino Y, 2006, AM J EPIDEMIOL, V164, P128, DOI 10.1093/aje/kwj185
   Furlan R, 2000, CIRCULATION, V102, P1912, DOI 10.1161/01.CIR.102.16.1912
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Gallicchio L, 2009, J SLEEP RES, V18, P148, DOI 10.1111/j.1365-2869.2008.00732.x
   Ghiasvand M, 2006, LIPIDS HEALTH DIS, V5, DOI 10.1186/1476-511X-5-9
   GOTO T, 1994, J HUM HYPERTENS, V8, P11
   Ha M, 2005, J OCCUP HEALTH, V47, P89, DOI 10.1539/joh.47.89
   Hansson GK, 2005, NEW ENGL J MED, V352, P1685, DOI 10.1056/NEJMra043430
   Härmä M, 2006, SCAND J WORK ENV HEA, V32, P502
   Härmä M, 2006, SCAND J WORK ENV HEA, V32, P413
   Haupt CM, 2008, ATHEROSCLEROSIS, V201, P205, DOI 10.1016/j.atherosclerosis.2007.12.059
   Hennig J, 1998, ERGONOMICS, V41, P610, DOI 10.1080/001401398186784
   Hublin C, 2007, SLEEP, V30, P1245, DOI 10.1093/sleep/30.10.1245
   Ito H, 2001, INT J CARDIOL, V79, P231, DOI 10.1016/S0167-5273(01)00439-9
   Jansen NWH, 2004, SCAND J WORK ENV HEA, V30, P139, DOI 10.5271/sjweh.771
   Jansen NWH, 2003, ERGONOMICS, V46, P664, DOI 10.1080/0014013031000085662
   Karasek R.A., 1990, Healthy work: stress, productivity, and the reconstruction of working life
   Karlsson B, 2005, SCAND J WORK ENV HEA, V31, P30, DOI 10.5271/sjweh.845
   Karlsson BH, 2003, INT ARCH OCC ENV HEA, V76, P424, DOI 10.1007/s00420-003-0440-y
   KAWACHI I, 1995, CIRCULATION, V92, P3178, DOI 10.1161/01.CIR.92.11.3178
   Kawakami N, 1999, J EPIDEMIOL COMMUN H, V53, P359, DOI 10.1136/jech.53.6.359
   Kitamura T, 2002, J HUM HYPERTENS, V16, P193, DOI 10.1038/sj.jhh.1001328
   Kivimäki M, 2006, PSYCHOSOM MED, V68, P402, DOI 10.1097/01.psy.0000221285.50314.d3
   Kivimäki M, 2006, SCAND J WORK ENV HEA, V32, P431, DOI 10.5271/sjweh.1049
   Knauth P., 1996, Shiftwork: problems and solutions, P17
   Knutsson A, 1999, OCCUP ENVIRON MED, V56, P46, DOI 10.1136/oem.56.1.46
   Knutsson A, 2004, CHRONOBIOL INT, V21, P1037, DOI 10.1081/CBI-200038525
   Kobayashi F, 1997, INT ARCH OCC ENV HEA, V69, P83
   KRISTENSEN TS, 1989, SCAND J WORK ENV HEA, V15, P165, DOI 10.5271/sjweh.1864
   Kroenke CH, 2007, AM J EPIDEMIOL, V165, P175, DOI 10.1093/aje/kwj355
   Lavie L, 2007, CHRONOBIOL INT, V24, P115, DOI 10.1080/07420520601139797
   LENNERNAS M, 1995, APPETITE, V25, P253, DOI 10.1006/appe.1995.0060
   Lin YC, 2009, CHRONOBIOL INT, V26, P740, DOI 10.1080/07420520902929029
   Lo SH, 2008, AM J HYPERTENS, V21, P759, DOI 10.1038/ajh.2008.186
   Lusardi P, 1999, AM J HYPERTENS, V12, P63, DOI 10.1016/S0895-7061(98)00200-3
   Mahmoodi BK, 2009, JAMA-J AM MED ASSOC, V301, P1790, DOI 10.1001/jama.2009.565
   Malmberg B, 2007, ACTA ANAESTH SCAND, V51, P823, DOI 10.1111/j.1399-6576.2007.01350.x
   Marshall NS, 2008, SLEEP MED REV, V12, P289, DOI 10.1016/j.smrv.2008.03.001
   Martins PJF, 2003, OCCUP ENVIRON MED, V60, P662, DOI 10.1136/oem.60.9.662
   McCully KS, 2009, ANN CLIN LAB SCI, V39, P219
   Meier-Ewert HK, 2004, J AM COLL CARDIOL, V43, P678, DOI 10.1016/j.jacc.2003.07.050
   Mejman T.F., 1998, HDB WORK ORG PSYCHOL
   Morikawa Y, 1999, SCAND J WORK ENV HEA, V25, P100, DOI 10.5271/sjweh.411
   Morikawa Y, 2005, SCAND J WORK ENV HEA, V31, P179, DOI 10.5271/sjweh.867
   Morikawa Y, 2008, J OCCUP HEALTH, V50, P270, DOI 10.1539/joh.L7116
   Morikawa Y, 2007, SCAND J WORK ENV HEA, V33, P45, DOI 10.5271/sjweh.1063
   Munakata M, 2001, HYPERTENS RES, V24, P25, DOI 10.1291/hypres.24.25
   Murata K, 2005, INT ARCH OCC ENV HEA, V78, P287, DOI 10.1007/s00420-004-0592-4
   Murata K, 1999, J OCCUP ENVIRON MED, V41, P748, DOI 10.1097/00043764-199909000-00006
   Murata K, 1999, SCAND J WORK ENV HEA, V25, P272, DOI 10.5271/sjweh.434
   Nabe-Nielsen K, 2008, SCAND J WORK ENV HEA, V34, P206, DOI 10.5271/sjweh.1230
   Nabe-Nielsen K, 2009, SCAND J WORK ENV HEA, V35, P48, DOI 10.5271/sjweh.1307
   Nagaya T, 2002, INT ARCH OCC ENV HEA, V75, P562, DOI 10.1007/s00420-002-0370-0
   Nakano Y, 1982, J Hum Ergol (Tokyo), V11 Suppl, P131
   Nazri S. Mohd, 2008, Southeast Asian Journal of Tropical Medicine and Public Health, V39, P176
   Nishitani N, 2007, IND HEALTH, V45, P296, DOI 10.2486/indhealth.45.296
   Ohira T, 2000, SCAND J WORK ENV HEA, V26, P421, DOI 10.5271/sjweh.563
   Oishi M, 2005, J HYPERTENS, V23, P2173, DOI 10.1097/01.hjh.0000189870.55914.b3
   Okamoto H, 2008, J OCCUP HEALTH, V50, P136, DOI 10.1539/joh.L6084
   Parkes K R, 1999, J Occup Health Psychol, V4, P256, DOI 10.1037/1076-8998.4.3.256
   Peter R, 1999, SCAND J WORK ENV HEA, V25, P376, DOI 10.5271/sjweh.448
   PETERNEL P, 1990, FIBRINOLYSIS, V4, P113, DOI 10.1016/0268-9499(90)90381-S
   Pietroiusti A, 2010, OCCUP ENVIRON MED, V67, P54, DOI 10.1136/oem.2009.046797
   Pilcher JJ, 2000, SLEEP, V23, P155
   Pisarski A, 1998, SCAND J WORK ENV HEA, V24, P141
   Pollitt RA, 2005, BMC PUBLIC HEALTH, V5, DOI 10.1186/1471-2458-5-7
   Puttonen S, 2009, ATHEROSCLEROSIS, V205, P608, DOI 10.1016/j.atherosclerosis.2009.01.016
   Radi S, 2007, AM J IND MED, V50, P584, DOI 10.1002/ajim.20492
   RODEN M, 1993, AM J PHYSIOL, V265, pR261, DOI 10.1152/ajpregu.1993.265.1.R261
   Sakata K, 2003, J OCCUP ENVIRON MED, V45, P1002, DOI 10.1097/01.jom.0000085893.98441.96
   SIEGRIST J, 1990, SOC SCI MED, V31, P1127, DOI 10.1016/0277-9536(90)90234-J
   Sookoian S, 2007, J INTERN MED, V261, P285, DOI 10.1111/j.1365-2796.2007.01766.x
   Spiegel K, 1999, LANCET, V354, P1435, DOI 10.1016/S0140-6736(99)01376-8
   Spiegel K, 2004, ANN INTERN MED, V141, P846, DOI 10.7326/0003-4819-141-11-200412070-00008
   Suwazono Y, 2008, HYPERTENSION, V52, P581, DOI 10.1161/HYPERTENSIONAHA.108.114553
   Suwazono Y, 2008, OBESITY, V16, P1887, DOI 10.1038/oby.2008.298
   Suwazono Y, 2006, J OCCUP ENVIRON MED, V48, P455, DOI 10.1097/01.jom.0000214355.69182.fa
   Tenkanen L, 1997, SCAND J WORK ENV HEA, V23, P257, DOI 10.5271/sjweh.218
   THEORELL T, 1976, ACTA MED SCAND, V200, P47
   TOUITOU Y, 1990, EUR J APPL PHYSIOL, V60, P288, DOI 10.1007/BF00379398
   Ursin R, 2009, SCAND J WORK ENV HEA, V35, P193, DOI 10.5271/sjweh.1325
   van Amelsvoort L. G. P. M., 2003, Occupational and Environmental Medicine, V60, pi83, DOI 10.1136/oem.60.suppl_1.i83
   van Amelsvoort LGPM, 2004, SCAND J WORK ENV HEA, V30, P149, DOI 10.5271/sjweh.772
   van Amelsvoort LGPM, 2001, OCCUP ENVIRON MED, V58, P678, DOI 10.1136/oem.58.10.678
   van Amelsvoort LGPM, 2000, INT ARCH OCC ENV HEA, V73, P255, DOI 10.1007/s004200050425
   van Amelsvoort LGPM, 2006, CHRONOBIOL INT, V23, P1105, DOI 10.1080/07420520601089539
   van Leeuwen WMA, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004589
   Viitasalo K, 2008, SCAND J WORK ENV HEA, V34, P198, DOI 10.5271/sjweh.1228
   Virkkunen H, 2006, OCCUP ENVIRON MED, V63, P378, DOI 10.1136/oem.2005.022558
   Virkkunen H, 2007, SCAND J WORK ENV HEA, V33, P425, DOI 10.5271/sjweh.1170
   Virtanen SV, 2002, INT J EPIDEMIOL, V31, P614, DOI 10.1093/ije/31.3.614
   Weir MR, 2007, CLIN J AM SOC NEPHRO, V2, P581, DOI 10.2215/CJN.03190906
   World Health Organization, 2007, Prevention of Cardiovascular Disease: Guidelines for Assessment and Management of Total Cardiovascular Risk
   Yadegarfar G, 2008, OCCUP ENVIRON MED, V65, P158, DOI 10.1136/oem.2006.030627
   Yamasaki F, 1998, HYPERTENSION, V32, P417, DOI 10.1161/01.HYP.32.3.417
NR 129
TC 387
Z9 430
U1 0
U2 58
PU SCANDINAVIAN JOURNAL WORK ENVIRONMENT & HEALTH
PI HELSINKI
PA TOPELIUKSENKATU 41A, SF-00250 HELSINKI, FINLAND
SN 0355-3140
EI 1795-990X
J9 SCAND J WORK ENV HEA
JI Scand. J. Work Environ. Health
PD MAR
PY 2010
VL 36
IS 2
SI SI
BP 96
EP 108
DI 10.5271/sjweh.2894
PG 13
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 562TW
UT WOS:000275078800003
PM 20087536
OA hybrid
DA 2025-06-11
ER

PT J
AU Sevim, BC
   Chela, H
   Ertugrul, H
   Malik, LS
   Malik, S
   Basar, O
   Daglilar, E
   Samiullah, S
   Gaballah, AH
   Tahan, V
AF Sevim, Burak C. C.
   Chela, Harleen
   Ertugrul, Hamza
   Malik, Lyiba S. S.
   Malik, Suha
   Basar, Omer
   Daglilar, Ebubekir
   Samiullah, Sami
   Gaballah, Ayman H. H.
   Tahan, Veysel
TI Non-Alcoholic Fatty Pancreas Disease: The Unsung Disease
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Review
DE Pancreatic cancer; fatty; pancreas; NAFPD; steatopancreatitis; obesity;
   non-alcoholic fatty liver disease
ID BETA-CELL FUNCTION; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; LIVER-DISEASE; ECTOPIC FAT; HYPERECHOGENIC PANCREAS;
   DIAMOND-SYNDROME; RISK-FACTOR; STEATOSIS
AB Non-alcoholic fatty pancreas disease (NAFPD) is a relatively new and emerging disease that is increasingly diagnosed yearly, like non-alcoholic fatty liver disease (NAFLD). It is associated especially with metabolic syndrome and obesity. As awareness of pancreatic steatosis and its clinical implications increase, it is diagnosed more frequently. The researchers have explained the clinical importance of NAFPD and the diseases it causes, such as pancreatitis, pancreatic insufficiency, and pancreatic cancer. Although the definitive treatment is not yet established, the primary treatment approach is weight loss since NAFPD is associated with metabolic syndrome as well as obesity. Although pharmacological agents, such as oral hypoglycemic agents, have been investigated in animal experiments, studies on humans have not been conducted. Since the research on NAFPD is still insufficient, it is a subject that needs to be investigated, and further studies are needed to explore its pathophysiology, clinical impact, and its management.
C1 [Sevim, Burak C. C.; Gaballah, Ayman H. H.] Univ Missouri, Dept Radiol, Columbia, MO 65212 USA.
   [Chela, Harleen; Daglilar, Ebubekir] West Virginia Univ, Dept Internal Med, Div Gastroenterol, Charleston Campus, Charleston, WV USA.
   [Ertugrul, Hamza; Malik, Lyiba S. S.; Malik, Suha; Tahan, Veysel] Univ Missouri, Dept Internal Med, Div Gastroenterol & Hepatol, Columbia, MO 65212 USA.
   [Malik, Lyiba S. S.; Malik, Suha] Univ Wisconsin, Milwaukee Coll Letters & Sci, Milwaukee, WI USA.
   [Basar, Omer; Samiullah, Sami] Summa Hlth Syst, Dept Internal Med, Div Gastroenterol, Akron, OH USA.
   [Basar, Omer; Samiullah, Sami] Northeast Ohio Med Univ, Akron, OH USA.
   [Tahan, Veysel] Univ Missouri, Div Gastroenterol & Hepatol, Hosp Dr CE405, Columbia, MO 65212 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Wisconsin System; University of Wisconsin Milwaukee; Summa
   Health System; University System of Ohio; Northeast Ohio Medical
   University (NEOMED); University of Missouri System; University of
   Missouri Columbia
RP Tahan, V (corresponding author), Univ Missouri, Div Gastroenterol & Hepatol, Hosp Dr CE405, Columbia, MO 65212 USA.
EM tahanv@health.missouri.edu
RI Chela, Harleen/LYO-1450-2024; Tahan, Veysel/K-4806-2019
OI Tahan, Veysel/0000-0001-6796-9359
CR Acharya C, 2013, GASTROENTEROLOGY, V145, P466, DOI 10.1053/j.gastro.2013.05.012
   Al Juboori A., 2020, OBESITY DIABETES NEW, P335
   Al-Haddad M, 2009, PANCREAS, V38, P672, DOI 10.1097/MPA.0b013e3181a9d5af
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   American College of Cardiology, 2014, Then and now
   [Anonymous], 2021, Overweight and Obesity
   [Anonymous], 1977, DIABETIC PANCREAS, DOI DOI 10.1007/978-1-4684-2325-9
   Begovatz P, 2015, DIABETOLOGIA, V58, P1646, DOI 10.1007/s00125-015-3544-5
   Berrington de Gonzalez A, 2003, BRIT J CANCER, V89, P519, DOI 10.1038/sj.bjc.6601140
   Bi Y, 2019, DIABETES-METAB RES, V35, DOI 10.1002/dmrr.3142
   Carter R, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0089505
   Catanzaro R, 2016, WORLD J GASTROENTERO, V22, P7660, DOI 10.3748/wjg.v22.i34.7660
   Chantarojanasiri T, 2015, J MED ULTRASON, V42, P177, DOI 10.1007/s10396-014-0576-2
   Chehter EZ, 2000, AIDS, V14, P1879, DOI 10.1097/00002030-200009080-00001
   Choi CW, 2010, WORLD J GASTROENTERO, V16, P4329, DOI 10.3748/wjg.v16.i34.4329
   Çubuk M, 2000, ACTA RADIOL, V41, P627, DOI 10.1034/j.1600-0455.2000.041006627.x
   DAENTL DL, 1979, AM J MED GENET, V3, P129, DOI 10.1002/ajmg.1320030203
   Della Corte C, 2015, CLIN ENDOCRINOL, V83, P656, DOI 10.1111/cen.12862
   DIAMOND I, 1960, PEDIATRICS, V25, P248
   Feldman M., 2016, SLEISENGER FORDTRANS, V10th ed, P1428
   Fernandes-Santos C, 2009, PANCREAS, V38, pE80, DOI 10.1097/MPA.0b013e3181987d9d
   FIEL SB, 1987, CHEST, V91, P181, DOI 10.1378/chest.91.2.181
   Fraulob JC, 2010, J CLIN BIOCHEM NUTR, V46, P212, DOI 10.3164/jcbn.09-83
   Glaser J, 2000, GERONTOLOGY, V46, P93, DOI 10.1159/000022141
   Gyllenhammer LE, 2016, INT J OBESITY, V40, P601, DOI 10.1038/ijo.2015.207
   Hague J, 2006, BRIT J RADIOL, V79, P627, DOI 10.1259/bjr/19356841
   Hanish SI, 2005, TRANSPL P, V37, P3564, DOI 10.1016/j.transproceed.2005.09.068
   Heni M, 2010, DIABETES-METAB RES, V26, P200, DOI 10.1002/dmrr.1073
   Honka H, 2015, J CLIN ENDOCR METAB, V100, P2015, DOI 10.1210/jc.2014-4236
   Hori M, 2014, CLIN TRANSL GASTROEN, V5, DOI 10.1038/ctg.2014.5
   Hu HH, 2010, OBESITY, V18, P841, DOI 10.1038/oby.2009.352
   Jia DM, 2001, AM J PHYSIOL-REG I, V280, pR1332, DOI 10.1152/ajpregu.2001.280.5.R1332
   JONES J S, 1970, British Journal of Diseases of the Chest, V64, P25
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kim SY, 2014, RADIOLOGY, V271, P104, DOI 10.1148/radiol.13122883
   Kul S, 2019, ACTA CARDIOL SIN, V35, P118, DOI 10.6515/ACS.201903_35(2).20181009A
   Le KA, 2011, DIABETES CARE, V34, P485, DOI 10.2337/dc10-0760
   Lee JH, 2008, J KOREAN MED SCI, V23, P142, DOI 10.3346/jkms.2008.23.1.142
   Lee JS, 2009, WORLD J GASTROENTERO, V15, P1869, DOI 10.3748/wjg.15.1869
   Lee Y, 2010, INT J OBESITY, V34, P396, DOI 10.1038/ijo.2009.245
   Lesmana CRA, 2017, GASTROENTEROLOGY, V152, pS897, DOI 10.1016/S0016-5085(17)33066-4
   Lim EL, 2011, DIABETOLOGIA, V54, P2506, DOI 10.1007/s00125-011-2204-7
   Lingvay I, 2009, J CLIN ENDOCR METAB, V94, P4070, DOI 10.1210/jc.2009-0584
   Lopez JM, 1996, GUT, V38, P285, DOI 10.1136/gut.38.2.285
   MARKS WM, 1980, RADIOLOGY, V137, P475, DOI 10.1148/radiology.137.2.7433680
   Martínez J, 2006, PANCREATOLOGY, V6, P206, DOI 10.1159/000092104
   Mathur Abhishek, 2007, HPB (Oxford), V9, P312, DOI 10.1080/13651820701504157
   Mathur A, 2007, ANN SURG, V246, P1058, DOI 10.1097/SLA.0b013e31814a6906
   Mathur A, 2009, J AM COLL SURGEONS, V208, P989, DOI 10.1016/j.jamcollsurg.2008.12.026
   MURAYAMA S, 1990, PEDIATR RADIOL, V20, P536, DOI 10.1007/BF02011384
   Navina S, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3002573
   Ogilvie RF, 1933, J PATHOL BACTERIOL, V37, P473, DOI 10.1002/path.1700370314
   Ogiu N, 1997, HEALTH PHYS, V72, P368, DOI 10.1097/00004032-199703000-00004
   OLSEN TS, 1978, ACTA PATH MICRO IM A, V86, P367
   Olufadi R, 2008, J CLIN PATHOL, V61, P697, DOI 10.1136/jcp.2007.048363
   Ou HY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0062561
   Papachristou GI, 2006, PANCREATOLOGY, V6, P279, DOI 10.1159/000092689
   Perumpail RB, 2015, DIGEST DIS SCI, V60, P3142, DOI 10.1007/s10620-015-3821-7
   Pezzilli R, 2014, WORLD J DIABETES, V5, P415, DOI 10.4239/wjd.v5.i4.415
   Pezzilli R, 2013, WORLD J GASTROENTERO, V19, P7930, DOI 10.3748/wjg.v19.i44.7930
   Pham YH, 2016, SOUTH MED J, V109, P196, DOI 10.14423/SMJ.0000000000000432
   Pinnick KE, 2008, OBESITY, V16, P522, DOI 10.1038/oby.2007.110
   Pinte L, 2019, ROM J INTERN MED, V57, P209, DOI 10.2478/rjim-2019-0005
   Piro S, 2012, J ENDOCRINOL INVEST, V35, P504, DOI 10.3275/7866
   Preziosi G, 2014, SURG ONCOL, V23, P61, DOI 10.1016/j.suronc.2014.02.003
   Ræder H, 2007, DIABETES, V56, P444, DOI 10.2337/db06-0859
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Reimer RA, 2014, J ENDOCRINOL, V220, P361, DOI 10.1530/JOE-13-0484
   Romana BS, 2018, ENDOCR METAB IMMUNE, V18, P547, DOI 10.2174/1871530318666180328111302
   Saisho Y, 2007, CLIN ANAT, V20, P933, DOI 10.1002/ca.20543
   Sarwar R, 2018, DIABET METAB SYND OB, V11, P533, DOI 10.2147/DMSO.S146339
   Sasaki M, 1998, PATHOL INT, V48, P566, DOI 10.1111/j.1440-1827.1998.tb03951.x
   Sattar N, 2014, BMC MED, V12, DOI 10.1186/s12916-014-0123-4
   Schaefer JH, 1926, ANAT RECORD, V32, P119, DOI 10.1002/ar.1090320204
   Sepe PS, 2011, GASTROINTEST ENDOSC, V73, P987, DOI 10.1016/j.gie.2011.01.015
   Singh RG, 2017, METABOLISM, V69, P1, DOI 10.1016/j.metabol.2016.12.012
   Smits MM, 2011, NAT REV GASTRO HEPAT, V8, P169, DOI 10.1038/nrgastro.2011.4
   STAMM BH, 1984, HUM PATHOL, V15, P677, DOI 10.1016/S0046-8177(84)80294-4
   Steven S, 2016, DIABETES CARE, V39, P158, DOI 10.2337/dc15-0750
   Szczepaniak LS, 2012, DIABETES CARE, V35, P2377, DOI 10.2337/dc12-0701
   Tahtaci M, 2018, TURK J GASTROENTEROL, V29, P588, DOI 10.5152/tjg.2018.17696
   Tajima K, 2017, AM J PHYSIOL-ENDOC M, V313, pE367, DOI 10.1152/ajpendo.00447.2016
   Tariq H, 2016, GASTROENTEROL RES, V9, P87, DOI 10.14740/gr731w
   THAM RTOTA, 1991, RADIOLOGY, V179, P183, DOI 10.1148/radiology.179.1.2006275
   Ustundag Y, 2011, WORLD J GASTROENTERO, V17, P2061, DOI 10.3748/wjg.v17.i15.2061
   van Raalte DH, 2010, CURR OPIN CLIN NUTR, V13, P478, DOI 10.1097/MCO.0b013e32833aa1ef
   WALTERS MNI, 1966, J PATHOL BACTERIOL, V92, P547, DOI 10.1002/path.1700920232
   Wang CY, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.113.000297
   WHO (World Health Organization), 2021, Obesity and overweight
   Wong VWS, 2014, AM J GASTROENTEROL, V109, P589, DOI 10.1038/ajg.2014.1
   Wu WC, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-77
   Yan MX, 2006, BIOCHEM BIOPH RES CO, V347, P192, DOI 10.1016/j.bbrc.2006.06.063
   Younossi ZM, 2019, J HEPATOL, V70, P531, DOI 10.1016/j.jhep.2018.10.033
   Yu TY, 2017, J DIABETES INVEST, V8, P735, DOI 10.1111/jdi.12665
   Zhao ZZ, 2015, PANCREAS, V44, P888, DOI 10.1097/MPA.0000000000000349
NR 95
TC 2
Z9 2
U1 2
U2 8
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2023
VL 23
IS 4
BP 485
EP 493
DI 10.2174/1871530322666220929142905
PG 9
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA I8WD8
UT WOS:001005522900008
PM 36177623
DA 2025-06-11
ER

PT J
AU Giussani, DA
   Davidge, ST
AF Giussani, D. A.
   Davidge, S. T.
TI Developmental programming of cardiovascular disease by prenatal hypoxia
SO JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
LA English
DT Review
DE cardiovascular dysfunction; fetal hypoxia; interventions; metabolic
   syndrome; treatment
ID INTRAUTERINE GROWTH RESTRICTION; PKC-EPSILON GENE; CHRONIC MODERATE
   HYPOXIA; INTIMA-MEDIA THICKNESS; HIGH-ALTITUDE HYPOXIA;
   LOW-BIRTH-WEIGHT; HIGH-FAT DIET; LONG-TERM; FETAL-GROWTH; ADULT MALE
AB It is now recognized that the quality of the fetal environment during early development is important in programming cardiovascular health and disease in later life. Fetal hypoxia is one of the most common consequences of complicated pregnancies worldwide. However, in contrast to the extensive research effort on pregnancy affected by maternal nutrition or maternal stress, the contribution of pregnancy affected by fetal chronic hypoxia to developmental programming is only recently becoming delineated and established. This review discusses the increasing body of evidence supporting the programming of cardiac susceptibility to ischaemia and reperfusion (I/R) injury, of endothelial dysfunction in peripheral resistance circulations, and of indices of the metabolic syndrome in adult offspring of hypoxic pregnancy. An additional focus of the review is the identification of plausible mechanisms and the implementation of maternal and early life interventions to protect against adverse programming.
C1 [Giussani, D. A.] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 3EG, England.
   [Davidge, S. T.] Univ Alberta, Women & Childrens Hlth Res Inst, Dept Obstet & Gynecol, Edmonton, AB, Canada.
   [Davidge, S. T.] Univ Alberta, Women & Childrens Hlth Res Inst, Dept Physiol, Edmonton, AB, Canada.
C3 University of Cambridge; University of Alberta; University of Alberta
RP Giussani, DA (corresponding author), Univ Cambridge, Dept Physiol Dev & Neurosci, Downing St, Cambridge CB2 3EG, England.
EM dag26@cam.ac.uk
OI Giussani, Dino/0000-0002-1308-1204; Davidge, Sandra/0000-0002-5559-4905
FU British Heart Foundation; Biotechnology and Biological Sciences Research
   Council; Isaac Newton Trust; Canadian Institutes of Health Research
   (CIHR); Heart and Stroke Foundation of Canada; Women and Children's
   Health Research Institute of the University of Alberta; BBSRC
   [BB/E002668/1] Funding Source: UKRI
FX D.G. is supported by The British Heart Foundation, The Biotechnology and
   Biological Sciences Research Council and the Isaac Newton Trust. S. D.
   is supported by the Canadian Institutes of Health Research (CIHR), Heart
   and Stroke Foundation of Canada and the Women and Children's Health
   Research Institute of the University of Alberta.
CR Agarwal A, 2005, TRENDS ENDOCRIN MET, V16, P127, DOI 10.1016/j.tem.2005.02.009
   Akira M, 2006, J PEDIATR-US, V148, P49, DOI 10.1016/j.jpeds.2005.06.044
   ALONSO JG, 1989, AM J PHYSIOL, V257, pH581, DOI 10.1152/ajpheart.1989.257.2.H581
   Armitage JA, 2004, J PHYSIOL-LONDON, V561, P355, DOI 10.1113/jphysiol.2004.072009
   ARNETT DK, 1994, AM J EPIDEMIOL, V140, P669, DOI 10.1093/oxfordjournals.aje.a117315
   Barker D.J. P., 1994, MOTHERS BABIES DIS L
   BARKER DJP, 1989, LANCET, V2, P577
   Baur JA, 2006, NATURE, V444, P337, DOI 10.1038/nature05354
   Baur JA, 2006, NAT REV DRUG DISCOV, V5, P493, DOI 10.1038/nrd2060
   Bertram CE, 2001, BRIT MED BULL, V60, P103, DOI 10.1093/bmb/60.1.103
   Bourque SL, 2012, PLACENTA, V33, P449, DOI 10.1016/j.placenta.2012.01.012
   BOYLE DW, 1990, PEDIATR RES, V28, P94, DOI 10.1203/00006450-199028020-00004
   Bristow MR, 2000, CIRCULATION, V101, P558, DOI 10.1161/01.CIR.101.5.558
   Browne VA, 1997, AM J PHYSIOL-HEART C, V272, pH1196, DOI 10.1152/ajpheart.1997.272.3.H1196
   Browne VA, 1997, AM J PHYSIOL-REG I, V273, pR2022, DOI 10.1152/ajpregu.1997.273.6.R2022
   Camm EJ, 2011, FASEB J, V25, P420, DOI 10.1096/fj.10-158188
   Camm EJ, 2010, AM J OBSTET GYNECOL, V203, DOI 10.1016/j.ajog.2010.06.046
   COHN HE, 1974, AM J OBSTET GYNECOL, V120, P817, DOI 10.1016/0002-9378(74)90587-0
   Conference Board of Canada, 2010, CAN HEART HLTH STRAT
   Cosmi E, 2009, OBSTET GYNECOL, V114, P1109, DOI 10.1097/AOG.0b013e3181bb23d3
   Crispi F, 2012, AM J OBSTET GYNECOL, V207, DOI 10.1016/j.ajog.2012.05.011
   Cruickshank K, 2002, CIRCULATION, V106, P2085, DOI 10.1161/01.CIR.0000033824.02722.F7
   Dalziel SR, 2005, LANCET, V365, P1856, DOI 10.1016/S0140-6736(05)66617-2
   Danson EJ, 2009, J MOL CELL CARDIOL, V46, P482, DOI 10.1016/j.yjmcc.2008.12.013
   Davidge ST, 2008, HYPERTENSION, V52, P808, DOI 10.1161/HYPERTENSIONAHA.108.120477
   Dolinsky VW, 2011, DIABETES, V60, P2274, DOI 10.2337/db11-0374
   Eskenazi B, 2007, HUM REPROD, V22, P3013, DOI 10.1093/humrep/dem301
   European Heart Network and European Society of Cardiology, 2012, EUROPEAN CARDIOVASCU
   Fall CHD, 1998, DIABETIC MED, V15, P220, DOI 10.1002/(SICI)1096-9136(199803)15:3<220::AID-DIA544>3.0.CO;2-O
   Fletcher AJW, 2000, ENDOCRINOLOGY, V141, P3976, DOI 10.1210/en.141.11.3976
   Gilbert RD, 2003, HIGH ALT MED BIOL, V4, P203, DOI 10.1089/152702903322022802
   Gilbert RD, 1998, COMP BIOCHEM PHYS A, V119, P669, DOI 10.1016/S1095-6433(98)01003-4
   GIUSSANI DA, 1993, J PHYSIOL-LONDON, V461, P431, DOI 10.1113/jphysiol.1993.sp019521
   Giussani DA, 2001, PEDIATR RES, V49, P490, DOI 10.1203/00006450-200104000-00009
   Giussani DA, 2007, J PHYSIOL-LONDON, V585, P911, DOI 10.1113/jphysiol.2007.141572
   Giussani DA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031017
   Gluckman PD, 2008, NEW ENGL J MED, V359, P61, DOI 10.1056/NEJMra0708473
   Halliwell B., 2004, FREE RADICALS BIOL M
   Hashimoto K, 2012, REPROD SCI, V19, P1001, DOI 10.1177/1933719112440052
   Hauton D, 2009, BMC CARDIOVASC DISOR, V9, DOI 10.1186/1471-2261-9-1
   Hauton D, 2012, COMP BIOCHEM PHYS A, V163, P278, DOI 10.1016/j.cbpa.2012.07.020
   Heidenreich PA, 2011, CIRCULATION, V123, P933, DOI 10.1161/CIR.0b013e31820a55f5
   Hemmings DG, 2005, AM J PHYSIOL-HEART C, V289, pH674, DOI 10.1152/ajpheart.00191.2005
   Herrera EA, 2012, J PHYSIOL-LONDON, V590, P1825, DOI 10.1113/jphysiol.2011.224576
   Herrera EA, 2012, J VASC RES, V49, P50, DOI 10.1159/000330666
   Huang RC, 2012, CLIN EXP PHARMACOL P, V39, P973, DOI 10.1111/j.1440-1681.2012.05746.x
   JACOBS R, 1988, J DEV PHYSIOL, V10, P97
   JONES CT, 1975, J PHYSIOL-LONDON, V248, P15, DOI 10.1113/jphysiol.1975.sp010960
   KAMITOMO M, 1992, AM J PHYSIOL, V262, pH399, DOI 10.1152/ajpheart.1992.262.2.H399
   KAMITOMO M, 1994, AM J PHYSIOL, V266, pR1778, DOI 10.1152/ajpregu.1994.266.6.R1778
   Kamitomo M, 2002, J SOC GYNECOL INVEST, V9, P335, DOI 10.1016/S1071-5576(02)00180-6
   KAMITOMO M, 1993, AM J OBSTET GYNECOL, V169, P701, DOI 10.1016/0002-9378(93)90646-Z
   Kane AD, 2012, J PHYSIOL-LONDON, V590, P323, DOI 10.1113/jphysiol.2011.217968
   Kim YH, 2005, J KOREAN MED SCI, V20, P13, DOI 10.3346/jkms.2005.20.1.13
   Koklu E, 2006, HORM RES, V65, P269, DOI 10.1159/000092536
   Koos BJ, 2011, AM J PHYSIOL-REG I, V301, pR601, DOI 10.1152/ajpregu.00664.2010
   Langley-Evans SC, 2005, MATERN CHILD NUTR, V1, P142, DOI 10.1111/j.1740-8709.2005.00015.x
   Leeson CPM, 2001, CIRCULATION, V103, P1264
   Leeson CPM, 1997, CIRCULATION, V96, P2233
   Lemley CO, 2012, AM J PHYSIOL-REG I, V302, pR454, DOI 10.1152/ajpregu.00407.2011
   Leon DA, 1998, BMJ-BRIT MED J, V317, P241, DOI 10.1136/bmj.317.7153.241
   Levitt Naomi S, 2002, Cardiovasc J S Afr, V13, P179
   Li GH, 2004, AM J PHYSIOL-HEART C, V286, pH1712, DOI 10.1152/ajpheart.00898.2003
   Li GH, 2003, J SOC GYNECOL INVEST, V10, P265, DOI 10.1016/S1071-5576(03)00074-1
   Lindgren I, 2011, POULTRY SCI, V90, P126, DOI 10.3382/ps.2010-00996
   Lindgren I, 2009, AM J PHYSIOL-REG I, V297, pR258, DOI 10.1152/ajpregu.00167.2009
   Louey S., 2003, Archives of Physiology and Biochemistry, V111, P53, DOI 10.1076/apab.111.1.53.15137
   Mayhew TM, 1999, HUM PATHOL, V30, P655, DOI 10.1016/S0046-8177(99)90090-4
   McEniery CM, 2005, J HUM HYPERTENS, V19, P507, DOI 10.1038/sj.jhh.1001814
   McMillen IC, 2005, PHYSIOL REV, V85, P571, DOI 10.1152/physrev.00053.2003
   McMillen IC, 2001, REPRODUCTION, V122, P195, DOI 10.1530/rep.0.1220195
   Miller SL, 2002, AM J OBSTET GYNECOL, V186, P261, DOI 10.1067/mob.2002.119629
   Miyague NI, 1997, FETAL DIAGN THER, V12, P332, DOI 10.1159/000264499
   Moore LG, 2011, RESP PHYSIOL NEUROBI, V178, P181, DOI 10.1016/j.resp.2011.04.017
   Morrison JL, 2008, CLIN EXP PHARMACOL P, V35, P730, DOI 10.1111/j.1440-1681.2008.04975.x
   Morrison S, 2003, J PHYSIOL-LONDON, V547, P283, DOI 10.1113/jphysiol.2002.032615
   Morton JS, 2011, J APPL PHYSIOL, V110, P1073, DOI 10.1152/japplphysiol.01174.2010
   Morton JS, 2010, AM J PHYSIOL-REG I, V298, pR930, DOI 10.1152/ajpregu.00641.2009
   Niu Y, 2013, 60 ANN SCI M MARCH 2
   Nuyt AM, 2008, CLIN SCI, V114, P1, DOI 10.1042/CS20070113
   Onishi J, 2004, J SOC GYNECOL INVEST, V11, P1, DOI 10.1016/j.jsgi.2003.07.003
   Parraguez VH, 2011, REPROD FERT DEVELOP, V23, P285, DOI 10.1071/RD10016
   Patterson AJ, 2010, CURR MOL MED, V10, P653
   Patterson AJ, 2012, CARDIOVASC RES, V93, P302, DOI 10.1093/cvr/cvr322
   Patterson AJ, 2010, CIRC RES, V107, P365, DOI 10.1161/CIRCRESAHA.110.221259
   PEREZ R, 1989, AM J PHYSIOL, V256, pR1011, DOI 10.1152/ajpregu.1989.256.5.R1011
   Ream M, 2008, AM J PHYSIOL-REG I, V295, pR583, DOI 10.1152/ajpregu.00771.2007
   Richardson BS, 1998, COMP BIOCHEM PHYS A, V119, P717, DOI 10.1016/S1095-6433(98)01010-1
   RichEdwards JW, 1997, BRIT MED J, V315, P396, DOI 10.1136/bmj.315.7105.396
   Richter HG, 2012, J PHYSIOL-LONDON, V590, P1377, DOI 10.1113/jphysiol.2011.226340
   Richter HG, 2009, J PINEAL RES, V46, P357, DOI 10.1111/j.1600-079X.2009.00671.x
   RIZZO G, 1995, ULTRASOUND OBST GYN, V5, P247, DOI 10.1046/j.1469-0705.1995.05040247.x
   Roseboom TJ, 1999, J HYPERTENS, V17, P325, DOI 10.1097/00004872-199917030-00004
   Rouwet EV, 2002, CIRCULATION, V105, P2791, DOI 10.1161/01.CIR.0000017497.47084.06
   Rueda-Clausen CF, 2012, AM J PHYSIOL-REG I, V303, pR418, DOI 10.1152/ajpregu.00148.2012
   Rueda-Clausen CF, 2011, CARDIOVASC RES, V90, P285, DOI 10.1093/cvr/cvq363
   Rueda-Clausen CF, 2011, DIABETES, V60, P507, DOI 10.2337/db10-1239
   Rueda-Clausen CF, 2009, CARDIOVASC RES, V81, P713, DOI 10.1093/cvr/cvn341
   Ruijtenbeek K, 2003, PFLUG ARCH EUR J PHY, V447, P158, DOI 10.1007/s00424-003-1170-4
   Ruijtenbeek K, 2003, PEDIATR RES, V53, P573, DOI 10.1203/01.PDR.0000055770.07236.98
   Ruijtenbeek K, 2000, CIRCULATION, V102, P2892
   Salem R, 2006, BRIT J ANAESTH, V97, P292, DOI 10.1093/bja/ael140
   Salinas CE, 2010, J DEV ORIG HLTH DIS, V1, P60, DOI 10.1017/S2040174409990043
   Seckl JR, 2004, ANN NY ACAD SCI, V1032, P63, DOI 10.1196/annals.1314.006
   Sharma SK, 2006, PEDIATR RES, V59, P116, DOI 10.1203/01.pdr.0000191579.63339.90
   Silva AAM, 2012, NUTR METAB CARDIOVAS, V22, P533, DOI 10.1016/j.numecd.2010.09.012
   Skilton MR, 2005, LANCET, V365, P1484, DOI 10.1016/S0140-6736(05)66419-7
   Stanley JL, 2012, HYPERTENSION, V59, P1021, DOI 10.1161/HYPERTENSIONAHA.111.186270
   Stanley JL, 2012, BIOL REPROD, V87, DOI 10.1095/biolreprod.111.096198
   Thakor AS, 2010, J PHYSIOL-LONDON, V588, P4235, DOI 10.1113/jphysiol.2010.196402
   Thakor AS, 2010, J PINEAL RES, V49, P399, DOI 10.1111/j.1600-079X.2010.00813.x
   Thompson JA, 2011, J PHYSIOL-LONDON, V589, P3319, DOI 10.1113/jphysiol.2011.210625
   Thompson LP, 2012, J PREGNANCY, V2012, DOI 10.1155/2012/582748
   Thompson LP, 2003, HIGH ALT MED BIOL, V4, P215, DOI 10.1089/152702903322022811
   Thompson LP, 1999, AM J OBSTET GYNECOL, V181, P105, DOI 10.1016/S0002-9378(99)70444-8
   Thompson LP, 2000, AM J PHYSIOL-REG I, V279, pR1813, DOI 10.1152/ajpregu.2000.279.5.R1813
   Tintu AN, 2007, ENDOTHELIUM-J ENDOTH, V14, P353, DOI 10.1080/10623320701746347
   Tintu A, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005155
   VEILLE JC, 1993, AM J PERINAT, V10, P275, DOI 10.1055/s-2007-994739
   Villamor E, 2004, AM J PHYSIOL-REG I, V287, pR642, DOI 10.1152/ajpregu.00611.2003
   Williams SJ, 2005, J PHYSIOL-LONDON, V565, P125, DOI 10.1113/jphysiol.2005.084889
   Williams SJ, 2005, AM J PHYSIOL-REG I, V288, pR360, DOI 10.1152/ajpregu.00178.2004
   World Health Organization (WHO), 2012, WORLD HLTH STAT
   Xiong FX, 2012, FASEB J, V26, P2753, DOI 10.1096/fj.11-199422
   Xu Y, 2006, FASEB J, V20, P1251, DOI 10.1096/fj.05-4917fje
   Xue Q, 2011, CARDIOVASC RES, V89, P300, DOI 10.1093/cvr/cvq303
   Xue Q, 2009, J PHARMACOL EXP THER, V330, P624, DOI 10.1124/jpet.109.153239
NR 127
TC 152
Z9 162
U1 0
U2 35
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2040-1744
EI 2040-1752
J9 J DEV ORIG HLTH DIS
JI J. Dev. Orig. Health Dis.
PD OCT
PY 2013
VL 4
IS 5
BP 328
EP 337
DI 10.1017/S204017441300010X
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 210QQ
UT WOS:000323849900002
PM 24970726
OA Bronze
DA 2025-06-11
ER

PT J
AU Garbarino, J
   Sturley, SL
AF Garbarino, Jeanne
   Sturley, Stephen L.
TI Saturated with fat: new parspectives on lipotoxicity
SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
LA English
DT Article
DE acyltransferases; fatty acids; insulin resistance; lipotoxicity;
   metabolic syndrome; neutral lipids
ID PANCREATIC BETA-CELL; ENDOPLASMIC-RETICULUM STRESS; YEAST
   SACCHAROMYCES-CEREVISIAE; PALMITATE-INDUCED APOPTOSIS; LONG-TERM
   EXPOSURE; FACTOR-KAPPA-B; MALONYL-COA; DIABETES-MELLITUS;
   ENDOTHELIAL-CELLS; ADIPOSE-TISSUE
AB Purpose of review
   To present current perspectives on the mediators and mechanisms of cyto-lipotoxic events and their relevance to human health.
   Recent findings
   The relatively recent isolation of lipid acyltransferase genes from yeast to mice and humans has resulted in a paradigm shift that now establishes all fatty acids as toxic, albeit in tissue specific patterns and by different mechanisms. Furthermore, the dysregulation of glucose homeostasis in combination with excess fatty acids provides a synergistic effect leading to glucolipotoxicity and cell death. These findings are relevant to the development of disease states associated with the pathogenesis of the metabolic syndrome.
   Summary
   In an era when an astounding number of people are diagnosed with metabolic disorders, it is imperative that we understand the consequences of a chronic metabolic surplus. Excessive fat, saturated or otherwise, has to be accommodated. Multiple aspects of this homeostasis are emerging, some of which are described here.
C1 [Sturley, Stephen L.] Columbia Univ, Med Ctr, Dept Pediat, New York, NY 10032 USA.
   [Garbarino, Jeanne; Sturley, Stephen L.] Columbia Univ, Med Ctr, Inst Human Nutr, New York, NY 10032 USA.
C3 Columbia University; Columbia University
RP Sturley, SL (corresponding author), Columbia Univ, Med Ctr, Dept Pediat, 630 W168th St, New York, NY 10032 USA.
EM sls37@columbia.edu
FU NIH [T32 DK007647]; American Diabetes Association; American Heart
   Association
FX This work was supported by the NIH, the American Diabetes Association
   and the American Heart Association (to SLS). JG received an NIH
   precloctoral fellowship in Nutrition (T32 DK007647).
CR Bergman RN, 2000, TRENDS ENDOCRIN MET, V11, P351, DOI 10.1016/S1043-2760(00)00323-4
   Briaud I, 2001, DIABETES, V50, P315, DOI 10.2337/diabetes.50.2.315
   Carman GM, 1996, J BIOL CHEM, V271, P13293, DOI 10.1074/jbc.271.23.13293
   Chai WD, 2007, ENDOCRINOLOGY, V148, P1622, DOI 10.1210/en.2006-1068
   Cnop M, 2007, DIABETES CARE, V30, P677, DOI 10.2337/dc06-1834
   Cnop M, 2007, J BIOL CHEM, V282, P3989, DOI 10.1074/jbc.M607627200
   CORKEY BE, 1989, J BIOL CHEM, V264, P21608
   Cunha DA, 2008, J CELL SCI, V121, P2308, DOI 10.1242/jcs.026062
   Cury-Boaventura MF, 2006, LIFE SCI, V78, P1448, DOI 10.1016/j.lfs.2005.07.038
   Cury-Boaventura MF, 2005, CLIN SCI, V108, P245, DOI 10.1042/CS20040281
   Cury-Boaventura MF, 2004, CLIN NUTR, V23, P721, DOI 10.1016/j.clnu.2003.12.004
   d'Azzo A, 2006, CELL DEATH DIFFER, V13, P404, DOI 10.1038/sj.cdd.4401834
   Dahlqvist A, 2000, P NATL ACAD SCI USA, V97, P6487, DOI 10.1073/pnas.120067297
   Daum G, 2000, MICROSC RES TECHNIQ, V51, P493, DOI 10.1002/1097-0029(20001215)51:6<493::AID-JEMT1>3.3.CO;2-6
   de Ferranti S, 2008, CLIN CHEM, V54, P945, DOI 10.1373/clinchem.2007.100156
   De Gottardi A, 2007, LAB INVEST, V87, P792, DOI 10.1038/labinvest.3700590
   Dulloo AG, 2004, INT J OBESITY, V28, pS29, DOI 10.1038/sj.ijo.0802861
   El-Assaad W, 2003, ENDOCRINOLOGY, V144, P4154, DOI 10.1210/en.2003-0410
   Frühbeck G, 2001, AM J PHYSIOL-ENDOC M, V280, pE827, DOI 10.1152/ajpendo.2001.280.6.E827
   Fruhbeck Gema, 2008, V456, P1, DOI 10.1007/978-1-59745-245-8_1
   Garbarino J, 2005, BIOCHEM SOC T, V33, P1182, DOI 10.1042/BST20051182
   GARLAND PB, 1962, NATURE, V195, P381, DOI 10.1038/195381a0
   HAGERTY BD, 2003, ACTA PHYSL SCAND, V178, P373
   Harmon JS, 2001, DIABETES, V50, P2481, DOI 10.2337/diabetes.50.11.2481
   Huang ZL, 2006, J NEUROCHEM, V97, P280, DOI 10.1111/j.1471-4159.2006.03733.x
   Jacqueminet S, 2000, METABOLISM, V49, P532, DOI 10.1016/S0026-0495(00)80021-9
   Kharroubi I, 2004, ENDOCRINOLOGY, V145, P5087, DOI 10.1210/en.2004-0478
   Klumpp S, 2006, BIOCHEM SOC T, V34, P1370, DOI 10.1042/BST0341370
   Kohlwein SD, 2007, CURR HYPERTENS REP, V9, P455, DOI 10.1007/s11906-007-0084-5
   Koyama K, 1997, AM J PHYSIOL-ENDOC M, V273, pE708, DOI 10.1152/ajpendo.1997.273.4.E708
   Laybutt DR, 1999, AM J PHYSIOL-ENDOC M, V277, pE1070, DOI 10.1152/ajpendo.1999.277.6.E1070
   LEE Y, 1994, P NATL ACAD SCI USA, V91, P10878, DOI 10.1073/pnas.91.23.10878
   Li CY, 2008, VALUE HEALTH, V11, P689, DOI 10.1111/j.1524-4733.2007.00307.x
   Listenberger LL, 2001, J BIOL CHEM, V276, P14890, DOI 10.1074/jbc.M010286200
   Listenberger LL, 2003, P NATL ACAD SCI USA, V100, P3077, DOI 10.1073/pnas.0630588100
   Malhi H, 2006, J BIOL CHEM, V281, P12093, DOI 10.1074/jbc.M510660200
   Malhi H, 2007, GUT, V56, P1124, DOI 10.1136/gut.2006.118059
   Marceau P, 1999, J CLIN ENDOCR METAB, V84, P1513, DOI 10.1210/jc.84.5.1513
   Martin CE, 2007, BBA-MOL CELL BIOL L, V1771, P271, DOI 10.1016/j.bbalip.2006.06.010
   McGarry JD, 1998, AM J CLIN NUTR, V67, p500S, DOI 10.1093/ajcn/67.3.500S
   MCGARRY JD, 1992, SCIENCE, V258, P766, DOI 10.1126/science.1439783
   MCGARRY JD, 1977, J CLIN INVEST, V60, P265, DOI 10.1172/JCI108764
   MCGARRY JD, 1997, FEBS J, V244, P1
   Mishra R, 2005, CARDIOVASC DIABETOL, V4, DOI 10.1186/1475-2840-4-2
   Mokdad AH, 2000, JAMA-J AM MED ASSOC, V284, P1650, DOI 10.1001/jama.284.13.1650
   Neel JV, 1998, PERSPECT BIOL MED, V42, P44
   Nogueiras R, 2008, REGUL PEPTIDES, V149, P26, DOI 10.1016/j.regpep.2007.09.034
   Oelkers P, 2000, J BIOL CHEM, V275, P15609, DOI 10.1074/jbc.C000144200
   Oelkers P, 2002, J BIOL CHEM, V277, P8877, DOI 10.1074/jbc.M111646200
   Oelkers P, 1998, J BIOL CHEM, V273, P26765, DOI 10.1074/jbc.273.41.26765
   Ostrander DB, 2001, J BIOL CHEM, V276, P38061
   Ota T, 2008, J CLIN INVEST, V118, P316, DOI 10.1172/JCI32752
   Poitout V, 2008, ENDOCR REV, V29, P351, DOI 10.1210/er.2007-0023
   PRENTKI M, 1992, J BIOL CHEM, V267, P5802
   Prentki M, 2002, DIABETES, V51, pS405, DOI 10.2337/diabetes.51.2007.S405
   Randle P J, 1966, Recent Prog Horm Res, V22, P1
   RANDLE PJ, 1963, LANCET, V1, P785
   Randle PJ, 1998, DIABETES METAB REV, V14, P263, DOI 10.1002/(SICI)1099-0895(199812)14:4<263::AID-DMR233>3.0.CO;2-C
   Reinbold M, 2008, MOL NUTR FOOD RES, V52, P581, DOI 10.1002/mnfr.200700321
   RICHTER EA, 1988, BIOCHEM J, V252, P733, DOI 10.1042/bj2520733
   Roche E, 1998, DIABETES, V47, P1086, DOI 10.2337/diabetes.47.7.1086
   Rosen ED, 2006, NATURE, V444, P847, DOI 10.1038/nature05483
   Sandager L, 2000, BIOCHEM SOC T, V28, P700
   Schaffer JE, 2003, CURR OPIN LIPIDOL, V14, P281, DOI 10.1097/00041433-200306000-00008
   Schwarz S, 2006, APOPTOSIS, V11, P1111, DOI 10.1007/s10495-006-6982-1
   Shimabukuro M, 1998, J BIOL CHEM, V273, P32487, DOI 10.1074/jbc.273.49.32487
   Shimabukuro M, 1998, P NATL ACAD SCI USA, V95, P2498, DOI 10.1073/pnas.95.5.2498
   Smith SJ, 2000, NAT GENET, V25, P87, DOI 10.1038/75651
   Stone SJ, 2004, J BIOL CHEM, V279, P11767, DOI 10.1074/jbc.M311000200
   Tabas I, 2002, J CLIN INVEST, V110, P905, DOI 10.1172/JCI200216452
   Trayhurn P, 2005, BIOCHEM SOC T, V33, P1078, DOI [10.1042/BST0331078, 10.1042/BST20051078]
   Trayhurn P, 2004, BRIT J NUTR, V92, P347, DOI 10.1079/BJN20041213
   Trayhurn P, 2006, PHILOS T R SOC B, V361, P1237, DOI 10.1098/rstb.2006.1859
   Turkish A, 2007, AM J PHYSIOL-GASTR L, V292, pG953, DOI 10.1152/ajpgi.00509.2006
   Turkish AR, 2005, J BIOL CHEM, V280, P14755, DOI 10.1074/jbc.M500025200
   Unger RH, 1999, P NATL ACAD SCI USA, V96, P2327, DOI 10.1073/pnas.96.5.2327
   Unger RH, 2002, BBA-MOL CELL BIOL L, V1585, P202, DOI 10.1016/S1388-1981(02)00342-6
   Yang HY, 1996, SCIENCE, V272, P1353, DOI 10.1126/science.272.5266.1353
   Zhang CH, 2008, BASIC RES CARDIOL, V103, P398, DOI 10.1007/s00395-008-0733-0
   Zhang Q, 2003, J BIOL CHEM, V278, P47145, DOI 10.1074/jbc.M306998200
   Zhu Y, 2005, NEUROCHEM INT, V46, P127, DOI 10.1016/j.neuint.2004.08.003
NR 81
TC 107
Z9 119
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1363-1950
EI 1473-6519
J9 CURR OPIN CLIN NUTR
JI Curr. Opin. Clin. Nutr. Metab. Care
PD MAR
PY 2009
VL 12
IS 2
BP 110
EP 116
DI 10.1097/MCO.0b013e32832182ee
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 420DK
UT WOS:000264268500002
PM 19202381
DA 2025-06-11
ER

PT J
AU Luo, QY
   Wei, Y
   Lv, XZ
   Chen, W
   Yang, DM
   Tuo, Q
AF Luo, Quanye
   Wei, Yu
   Lv, Xuzhen
   Chen, Wen
   Yang, Dongmei
   Tuo, Qinhui
TI The Effect and Mechanism of Oleanolic Acid in the Treatment of Metabolic
   Syndrome and Related Cardiovascular Diseases
SO MOLECULES
LA English
DT Review
DE oleanolic acid; metabolic syndrome; cardiovascular diseases
ID ORUJO OLIVE OIL; NF-KAPPA-B; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   HIGH-FAT; DIABETIC-NEPHROPATHY; ENDOTHELIAL FUNCTION;
   MYOCARDIAL-ISCHEMIA; IN-VIVO; ANTIOXIDANT
AB Metabolic syndromes (MetS) and related cardiovascular diseases (CVDs) pose a serious threat to human health. MetS are metabolic disorders characterized by obesity, dyslipidemia, and hypertension, which increase the risk of CVDs' initiation and development. Although there are many availabile drugs for treating MetS and related CVDs, some side effects also occur. Considering the low-level side effects, many natural products have been tried to treat MetS and CVDs. A five-cyclic triterpenoid natural product, oleanolic acid (OA), has been reported to have many pharmacologic actions such as anti-hypertension, anti-hyperlipidemia, and liver protection. OA has specific advantages in the treatment of MetS and CVDs. OA achieves therapeutic effects through a variety of pathways, attracting great interest and playing a vital role in the treatment of MetS and CVDs. Consequently, in this article, we aim to review the pharmacological actions and potential mechanisms of OA in treating MetS and related CVDs.
C1 [Luo, Quanye; Wei, Yu; Chen, Wen; Yang, Dongmei; Tuo, Qinhui] Hunan Univ Chinese Med, Med Sch, Key Lab Vasc Biol & Translat Med, Changsha 410208, Peoples R China.
   [Lv, Xuzhen] Hunan Univ Chinese Med, Sch Pharm, Key Lab Qual Evaluat Bulk Herbs Hunan Prov, Changsha 410208, Peoples R China.
C3 Hunan University of Chinese Medicine; Hunan University of Chinese
   Medicine
RP Yang, DM; Tuo, Q (corresponding author), Hunan Univ Chinese Med, Med Sch, Key Lab Vasc Biol & Translat Med, Changsha 410208, Peoples R China.
EM 20223777@stu.hnucm.edu.cn; 20223776@stu.hnucm.edu.cn;
   20232054@stu.hnucm.edu.cn; chenwen@biochen.org; dongmeiy@hnucm.edu.cn;
   qinhuituo@hnucm.edu.cn
OI Chen, Wen/0000-0002-9522-4036; Luo, Quanye/0009-0008-5640-799X
FU Key Research and Development Projects of the Hunan Provincial Science
   and Technology Department
FX No Statement Available
CR Acelajado MC, 2019, CIRC RES, V124, P1061, DOI 10.1161/CIRCRESAHA.118.312156
   Acín S, 2021, J ETHNOPHARMACOL, V265, DOI 10.1016/j.jep.2020.113298
   Ahn YM, 2017, EUR J PHARMACOL, V809, P231, DOI 10.1016/j.ejphar.2017.05.030
   Ali AT, 2013, EUR J CELL BIOL, V92, P229, DOI 10.1016/j.ejcb.2013.06.001
   Alwardat N, 2018, DIABETES METAB SYND, V12, P661, DOI 10.1016/j.dsx.2018.04.011
   Bachhav SS, 2015, PHARMACOGN RES, V7, P385, DOI 10.4103/0974-8490.159575
   Bachhav SS, 2011, PHYTOTHER RES, V25, P1435, DOI 10.1002/ptr.3431
   Bacon SL, 2004, SPORTS MED, V34, P307, DOI 10.2165/00007256-200434050-00003
   Baloyi CM, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/6753541
   Bartal MF, 2023, AM J OBSTET GYNECOL, V228, p571e1, DOI 10.1016/j.ajog.2023.01.015
   Barton M, 2019, HYPERTENSION, V74, P1232, DOI 10.1161/HYPERTENSIONAHA.119.12105
   Batty M, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11233843
   Bjursell M, 2007, DIABETES, V56, P583, DOI 10.2337/db06-1432
   Buus NH, 2011, EUR J PHARMACOL, V670, P519, DOI 10.1016/j.ejphar.2011.09.037
   Cao JH, 2015, BIOSCI TRENDS, V9, P315, DOI 10.5582/bst.2015.01094
   Castellano JM, 2022, NUTRIENTS, V14, DOI 10.3390/nu14030623
   Chan CY, 2014, FREE RADICAL RES, V48, P402, DOI 10.3109/10715762.2014.880113
   Chen SY, 2017, FASEB J, V31, P1085, DOI 10.1096/fj.201601022R
   Chen SL, 2003, AM J PHYSIOL-ENDOC M, V284, pE1089, DOI 10.1152/ajpendo.00540.2002
   Chen Z, 2020, FREE RADICAL BIO MED, V152, P116, DOI 10.1016/j.freeradbiomed.2020.02.025
   Chylikova J, 2018, BIOMED PAP, V162, P79, DOI 10.5507/bp.2018.015
   Davidsen L, 2024, EUR J ENDOCRINOL, V190, P44, DOI 10.1093/ejendo/lvad175
   de la Torre R, 2020, FOOD CHEM, V322, DOI 10.1016/j.foodchem.2020.126676
   de Melo CL, 2010, CHEM-BIOL INTERACT, V185, P59, DOI 10.1016/j.cbi.2010.02.028
   De Stefani C, 2022, PHARMACEUTICS, V14, DOI 10.3390/pharmaceutics14102232
   Dentin R, 2005, BIOCHIMIE, V87, P81, DOI 10.1016/j.biochi.2004.11.008
   Djeziri FZ, 2018, BIOCHIMIE, V152, P110, DOI 10.1016/j.biochi.2018.06.025
   Du Y, 2006, PLANTA MED, V72, P222, DOI 10.1055/s-2005-916197
   Dubey VK, 2013, J PHARMACOL PHARMACO, V4, P47, DOI 10.4103/0976-500X.107678
   Elizalde-Velazquez Gustavo Axel, 2023, Chemosphere, V341, P140070, DOI 10.1016/j.chemosphere.2023.140070
   Escobar-Peso A, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12122102
   Fruman DA, 1998, ANNU REV BIOCHEM, V67, P481, DOI 10.1146/annurev.biochem.67.1.481
   Gamede M, 2021, BIOMED PHARMACOTHER, V139, DOI 10.1016/j.biopha.2021.111570
   Gamede M, 2020, THER ADV ENDOCRINOL, V11, DOI 10.1177/2042018820935771
   Gamede M, 2019, DIABET METAB SYND OB, V12, P1953, DOI 10.2147/DMSO.S218626
   Gamede M, 2019, MOLECULES, V24, DOI 10.3390/molecules24020340
   Gamede M, 2018, MOLECULES, V23, DOI 10.3390/molecules23040794
   Gao DW, 2007, CAN J PHYSIOL PHARM, V85, P1076, DOI 10.1139/Y07-098
   Gao DW, 2009, PHYTOTHER RES, V23, P1257, DOI 10.1002/ptr.2603
   García-González A, 2023, FOOD FUNCT, V14, P9681, DOI [10.1039/D3FO02725B, 10.1039/d3fo02725b]
   Glass CK, 2012, CELL METAB, V15, P635, DOI 10.1016/j.cmet.2012.04.001
   Gross B, 2017, NAT REV ENDOCRINOL, V13, P36, DOI 10.1038/nrendo.2016.135
   Gugliucci A, 1996, DIABETOLOGIA, V39, P149, DOI 10.1007/BF00403957
   Hankey GJ, 2017, LANCET, V389, P641, DOI 10.1016/S0140-6736(16)30962-X
   He JN, 2024, CARDIOVASC DIABETOL, V23, DOI 10.1186/s12933-023-02110-0
   Honma M, 2018, INT J OBESITY, V42, P1544, DOI 10.1038/s41366-018-0062-9
   Huang THW, 2005, J CARDIOVASC PHARM, V46, P856, DOI 10.1097/01.fjc.0000190489.85058.7e
   Huang XJ, 2018, INT J BIOL SCI, V14, P1483, DOI 10.7150/ijbs.27173
   Iskender H, 2022, BIOTECH HISTOCHEM, V97, P269, DOI 10.1080/10520295.2021.1954691
   Ji L, 2022, PHYTOMEDICINE, V104, DOI 10.1016/j.phymed.2022.154329
   Jiang QK, 2016, EUR J PHARM BIOPHARM, V99, P65, DOI 10.1016/j.ejpb.2015.11.013
   Jiang QX, 2015, INT J BIOCHEM CELL B, V69, P142, DOI 10.1016/j.biocel.2015.10.023
   Joseph P, 2017, CIRC RES, V121, P677, DOI 10.1161/CIRCRESAHA.117.308903
   Kadowaki T, 2006, J CLIN INVEST, V116, P1784, DOI 10.1172/JCI29126
   Katso R, 2001, ANNU REV CELL DEV BI, V17, P615, DOI 10.1146/annurev.cellbio.17.1.615
   Kawai T, 2021, AM J PHYSIOL-CELL PH, V320, pC375, DOI 10.1152/ajpcell.00379.2020
   Kerkela R, 2007, TRENDS CARDIOVAS MED, V17, P91, DOI 10.1016/j.tcm.2007.01.004
   Khathi A, 2013, J DIABETES, V5, P80, DOI 10.1111/j.1753-0407.2012.00230.x
   Kim HY, 2013, EUR J PHARMACOL, V710, P73, DOI 10.1016/j.ejphar.2013.04.005
   Kim HS, 2013, NUTR RES, V33, P144, DOI 10.1016/j.nutres.2012.12.006
   Kumarswamy R, 2012, EUR HEART J, V33, P1067, DOI 10.1093/eurheartj/ehs043
   Kwan TW, 2023, CIRCULATION, V148, P74, DOI 10.1161/CIR.0000000000001145
   Lazar MA, 2007, HORM METAB RES, V39, P710, DOI 10.1055/s-2007-985897
   Lee ES, 2016, NEPHROL DIAL TRANSPL, V31, P391, DOI 10.1093/ndt/gfv377
   Lee JJ, 2007, ARCH PHARM RES, V30, P210, DOI 10.1007/BF02977696
   Leung C, 2016, NAT REV GASTRO HEPAT, V13, P412, DOI 10.1038/nrgastro.2016.85
   Li M, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/643102
   Li WQ, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.697483
   Li WF, 2017, EXP THER MED, V14, P848, DOI 10.3892/etm.2017.4527
   Li Y, 2014, TOXICOL APPL PHARM, V277, P155, DOI 10.1016/j.taap.2014.03.016
   Liao HH, 2015, MOL CELL BIOCHEM, V409, P145, DOI 10.1007/s11010-015-2520-1
   Libby P, 2021, NATURE, V592, P524, DOI 10.1038/s41586-021-03392-8
   Lin JD, 2005, CELL, V120, P261, DOI 10.1016/j.cell.2004.11.043
   Lin KL, 2022, PHARMACEUTICALS-BASE, V15, DOI 10.3390/ph15010001
   Lin WJ, 2023, J ETHNOPHARMACOL, V301, DOI 10.1016/j.jep.2022.115802
   Lin YN, 2018, J AGR FOOD CHEM, V66, P10964, DOI 10.1021/acs.jafc.8b03372
   Lin YG, 2011, EVID-BASED COMPL ALT, V2011, P1, DOI 10.1093/ecam/nep007
   Liu CJ, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/534084
   Liu J, 1995, J ETHNOPHARMACOL, V49, P57, DOI 10.1016/0378-8741(95)90032-2
   Liu Y, 2022, BIOCHEM BIOPH RES CO, V636, P1, DOI 10.1016/j.bbrc.2022.10.074
   Lontchi-Yimagou E, 2013, CURR DIABETES REP, V13, P435, DOI 10.1007/s11892-013-0375-y
   Loza-Rodríguez H, 2020, EUR J PHARMACOL, V883, DOI 10.1016/j.ejphar.2020.173252
   Lu MK, 2024, BMC PUBLIC HEALTH, V24, DOI 10.1186/s12889-023-17573-9
   Luan JW, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms241914494
   LUDWIG J, 1980, MAYO CLIN PROC, V55, P434
   Luo HQ, 2018, CHIN J NAT MEDICINES, V16, P339, DOI 10.1016/S1875-5364(18)30065-7
   Luo HQ, 2017, ACTA BIOCH BIOPH SIN, V49, P349, DOI 10.1093/abbs/gmx013
   Madlala HP, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0147395
   Mapanga RF, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047322
   Matsui T, 2001, CIRCULATION, V104, P330
   Matumba MG, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020226
   Mohammed A, 2021, NAT PROD RES, V35, P788, DOI 10.1080/14786419.2019.1596094
   Mohandes S, 2023, J CLIN INVEST, V133, DOI 10.1172/JCI165654
   Molepo M, 2018, MOLECULES, V23, DOI 10.3390/molecules23102528
   Mukundwa A, 2016, BIOCHEM BIOPH RES CO, V471, P315, DOI 10.1016/j.bbrc.2016.02.012
   Mukundwa A, 2016, J DIABETES, V8, P98, DOI 10.1111/1753-0407.12260
   Musabayane CT, 2010, RENAL FAILURE, V32, P832, DOI 10.3109/0886022X.2010.494802
   Nakae J, 2001, J CLIN INVEST, V108, P1359, DOI 10.1172/JCI200112876
   Napetschnig J, 2013, ANNU REV BIOPHYS, V42, P443, DOI 10.1146/annurev-biophys-083012-130338
   Nelson RH, 2013, PRIMARY CARE, V40, P195, DOI 10.1016/j.pop.2012.11.003
   Ngubane PS, 2011, RENAL FAILURE, V33, P434, DOI 10.3109/0886022X.2011.568147
   Nosadini R, 2011, NUTR METAB CARDIOVAS, V21, P79, DOI 10.1016/j.numecd.2010.10.002
   Nyakudya TT, 2018, J DEV ORIG HLTH DIS, V9, P500, DOI 10.1017/S2040174418000259
   Nyakudya TT, 2018, NUTR METAB, V15, DOI 10.1186/s12986-018-0314-7
   Orellana-Urzúa S, 2020, CURR PHARM DESIGN, V26, P4246, DOI 10.2174/1381612826666200708133912
   Pan YY, 2018, BIOMED PHARMACOTHER, V97, P1694, DOI 10.1016/j.biopha.2017.11.151
   Piché ME, 2020, CIRC RES, V126, P1477, DOI 10.1161/CIRCRESAHA.120.316101
   Pollier J, 2012, PHYTOCHEMISTRY, V77, P10, DOI 10.1016/j.phytochem.2011.12.022
   Pozo OJ, 2017, ANAL CHIM ACTA, V990, P84, DOI 10.1016/j.aca.2017.07.041
   Qi CY, 2017, J DIABETES RES, V2017, DOI 10.1155/2017/8637138
   Qin ZB, 2020, DRUG DES DEV THER, V14, P4407, DOI 10.2147/DDDT.S272877
   Rada M, 2015, BIOMED CHROMATOGR, V29, P1687, DOI 10.1002/bmc.3480
   Ratziu V, 2010, J HEPATOL, V53, P372, DOI 10.1016/j.jhep.2010.04.008
   Repa JJ, 2000, GENE DEV, V14, P2819, DOI 10.1101/gad.844900
   Rodriguez-Rodriguez R, 2006, J AGR FOOD CHEM, V54, P2096, DOI 10.1021/jf0528512
   Rodriguez-Rodriguez R, 2007, AM J HYPERTENS, V20, P728, DOI 10.1016/j.amjhyper.2007.01.012
   Rodriguez-Rodriguez R, 2009, BRIT J NUTR, V102, P1435, DOI 10.1017/S0007114509990754
   Rodríguez-Rodríguezl R, 2004, BRIT J NUTR, V92, P635, DOI 10.1079/BJN20041231
   Rong ZT, 2011, PHARM BIOL, V49, P78, DOI 10.3109/13880209.2010.499130
   Sanchez-Rodriguez E, 2019, NUTRIENTS, V11, DOI 10.3390/nu11030561
   Santos-Lozano JM, 2019, DIABETES OBES METAB, V21, P2526, DOI 10.1111/dom.13838
   Saravanakumar K, 2021, FOOD CHEM TOXICOL, V155, DOI 10.1016/j.fct.2021.112374
   Sato H, 2007, BIOCHEM BIOPH RES CO, V362, P793, DOI 10.1016/j.bbrc.2007.06.130
   Sciarretta S, 2014, CIRC RES, V114, P549, DOI 10.1161/CIRCRESAHA.114.302022
   Senthil S, 2007, TOXICOL PATHOL, V35, P418, DOI 10.1080/01926230701230312
   Shen SY, 2023, PHYTOMEDICINE, V108, DOI 10.1016/j.phymed.2022.154519
   Shi YW, 2024, ENVIRON POLLUT, V342, DOI 10.1016/j.envpol.2023.123114
   Shi YJ, 2021, EXP NEUROL, V343, DOI 10.1016/j.expneurol.2021.113785
   Shola OB, 2015, ANEMIA, V2015, DOI 10.1155/2015/848921
   Rossi JLS, 2022, DIABETES-METAB RES, V38, DOI 10.1002/dmrr.3502
   Siti HN, 2015, VASC PHARMACOL, V71, P40, DOI 10.1016/j.vph.2015.03.005
   Somova LO, 2003, PHYTOMEDICINE, V10, P115, DOI 10.1078/094471103321659807
   Song M, 2006, J PHARMACEUT BIOMED, V40, P190, DOI 10.1016/j.jpba.2005.06.034
   Stelling-Férez J, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms241914860
   Su SH, 2018, FREE RADICAL BIO MED, V124, P122, DOI 10.1016/j.freeradbiomed.2018.06.003
   Sun C, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22168974
   Sung HY, 2010, NUTR RES, V30, P831, DOI 10.1016/j.nutres.2010.10.001
   Swynghedauw B, 1999, PHYSIOL REV, V79, P215, DOI 10.1152/physrev.1999.79.1.215
   Teodoro T, 2008, FEBS LETT, V582, P1375, DOI 10.1016/j.febslet.2008.03.026
   Thomas CC, 2015, MED CLIN N AM, V99, P1, DOI 10.1016/j.mcna.2014.08.015
   Thomas C, 2009, CELL METAB, V10, P167, DOI 10.1016/j.cmet.2009.08.001
   Tuomilehto J, 2001, NEW ENGL J MED, V344, P1343, DOI 10.1056/NEJM200105033441801
   Vilahur G, 2018, J AM COLL CARDIOL, V72, P781, DOI 10.1016/j.jacc.2018.05.053
   Wan Q, 2015, HUM CELL, V28, P5, DOI 10.1007/s13577-014-0097-8
   Wang S, 2018, BIOMED PHARMACOTHER, V108, P1181, DOI 10.1016/j.biopha.2018.09.150
   Wang X, 2017, CELL DEATH DIFFER, V24, P1588, DOI 10.1038/cdd.2017.85
   Wang X, 2013, MOL CELL ENDOCRINOL, V376, P70, DOI 10.1016/j.mce.2013.06.014
   Wang X, 2011, PHYTOTHER RES, V25, P1031, DOI 10.1002/ptr.3385
   Wang X, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/973287
   Wang ZH, 2010, EUR J PHARMACOL, V628, P255, DOI 10.1016/j.ejphar.2009.11.019
   Ward NC, 2019, CIRC RES, V124, P328, DOI 10.1161/CIRCRESAHA.118.312782
   White UA, 2010, MOL CELL ENDOCRINOL, V318, P10, DOI 10.1016/j.mce.2009.08.023
   Wu DW, 2018, AM J CHINESE MED, V46, P1187, DOI [10.1142/s0192415x18500623, 10.1142/S0192415X18500623]
   Wu LQ, 2020, FRONT MOL NEUROSCI, V13, DOI 10.3389/fnmol.2020.00028
   Wu Q, 2021, J CLIN INVEST, V131, DOI 10.1172/JCI142865
   Xue CY, 2021, J AGR FOOD CHEM, V69, P7884, DOI 10.1021/acs.jafc.1c02257
   Yan JW, 2020, TRENDS CELL BIOL, V30, P979, DOI 10.1016/j.tcb.2020.09.006
   Yan Y, 2022, J BIOMED NANOTECHNOL, V18, P474, DOI 10.1166/jbn.2022.3262
   Yang Rui, 2013, Int J Nanomedicine, V8, P2917, DOI 10.2147/IJN.S47510
   Yin MC, 2012, J AGR FOOD CHEM, V60, P7697, DOI 10.1021/jf302529x
   Yoo SR, 2017, PHARMACOGN MAG, V13, P339, DOI 10.4103/0973-1296.211023
   Yunoki K, 2008, J AGR FOOD CHEM, V56, P12052, DOI 10.1021/jf8026217
   Zeng XY, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0042115
   Zhang PJ, 2020, FRONT MED-PRC, V14, P583, DOI 10.1007/s11684-019-0729-1
   Zhang SM, 2020, INT J MOL MED, V46, P2019, DOI 10.3892/ijmm.2020.4744
   Zhang YX, 2021, J ETHNOPHARMACOL, V266, DOI 10.1016/j.jep.2020.113436
   Zhang YH, 2015, INFLAMM RES, V64, P253, DOI 10.1007/s00011-015-0805-1
   Zhang ZH, 2017, SCI REP-UK, V7, DOI 10.1038/srep40237
NR 168
TC 8
Z9 8
U1 4
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD FEB
PY 2024
VL 29
IS 4
AR 758
DI 10.3390/molecules29040758
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA JI9R4
UT WOS:001172658900001
PM 38398510
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gillies, NA
   Franzke, B
   Wessner, B
   Schober-Halper, B
   Hofmann, M
   Oesen, S
   Tosevska, A
   Strasser, EM
   Roy, NC
   Milan, AM
   Cameron-Smith, D
   Wagner, KH
AF Gillies, Nicola A.
   Franzke, Bernhard
   Wessner, Barbara
   Schober-Halper, Barbara
   Hofmann, Marlene
   Oesen, Stefan
   Tosevska, Anela
   Strasser, Eva-Maria
   Roy, Nicole C.
   Milan, Amber M.
   Cameron-Smith, David
   Wagner, Karl-Heinz
TI Nutritional supplementation alters associations between one-carbon
   metabolites and cardiometabolic risk profiles in older adults: a
   secondary analysis of the Vienna Active Ageing Study
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Choline; Homocysteine; Nutritional supplement; Older adults; One-carbon
   metabolism
ID PLASMA HOMOCYSTEINE; PHYSICAL-ACTIVITY; CARDIOVASCULAR-DISEASE;
   RESISTANCE EXERCISE; CHOLINE METABOLITES; OXIDATIVE STRESS;
   UNITED-STATES; ELDERLY-MEN; BETAINE; FOLATE
AB Purpose Cardiovascular diseases and cognitive decline, predominant in ageing populations, share common features of dysregulated one-carbon (1C) and cardiometabolic homeostasis. However, few studies have addressed the impact of multifaceted lifestyle interventions in older adults that combine both nutritional supplementation and resistance training on the co-regulation of 1C metabolites and cardiometabolic markers. Methods 95 institutionalised older adults (83 +/- 6 years, 88.4% female) were randomised to receive resistance training with or without nutritional supplementation (Fortifit), or cognitive training (control for socialisation) for 6 months. Fasting plasma 1C metabolite concentrations, analysed by liquid chromatography coupled with mass spectrometry, and cardiometabolic parameters were measured at baseline and the 3- and 6-month follow-ups. Results Regardless of the intervention group, choline was elevated after 3 months, while cysteine and methionine remained elevated after 6 months (mixed model time effects, p < 0.05). Elevated dimethylglycine and lower betaine concentrations were correlated with an unfavourable cardiometabolic profile at baseline (spearman correlations, p < 0.05). However, increasing choline and dimethylglycine concentrations were associated with improvements in lipid metabolism in those receiving supplementation (regression model interaction, p < 0.05). Conclusion Choline metabolites, including choline, betaine and dimethylglycine, were central to the co-regulation of 1C metabolism and cardiometabolic health in older adults. Metabolites that indicate upregulated betaine-dependent homocysteine remethylation were elevated in those with the greatest cardiometabolic risk at baseline, but associated with improvements in lipid parameters following resistance training with nutritional supplementation. The relevance of how 1C metabolite status might be optimised to protect against cardiometabolic dysregulation requires further attention.
C1 [Gillies, Nicola A.; Roy, Nicole C.; Milan, Amber M.; Cameron-Smith, David] Univ Auckland, Liggins Inst, Auckland, New Zealand.
   [Gillies, Nicola A.; Roy, Nicole C.; Cameron-Smith, David] Riddet Inst, Palmerston North, New Zealand.
   [Franzke, Bernhard; Wessner, Barbara; Schober-Halper, Barbara; Hofmann, Marlene; Oesen, Stefan; Tosevska, Anela; Wagner, Karl-Heinz] Univ Vienna, Res Platform Act Ageing, Althanstr 14, A-1090 Vienna, Austria.
   [Wessner, Barbara] Univ Vienna, Dept Sports Med Exercise Physiol & Prevent, Vienna, Austria.
   [Tosevska, Anela] Med Univ Vienna, Div Rheumatol, Internal Med 3, Vienna, Austria.
   [Strasser, Eva-Maria] Kaiser Franz Josef Hosp, Social Med Ctr South, Inst Phys Med & Rehabil, Vienna, Austria.
   [Roy, Nicole C.; Milan, Amber M.] AgResearch, Food Nutr & Hlth, Hamilton, New Zealand.
   [Roy, Nicole C.; Milan, Amber M.] High Value Nutr Natl Sci Challenge, Auckland, New Zealand.
   [Roy, Nicole C.] Univ Otago, Dept Human Nutr, Dunedin, New Zealand.
   [Cameron-Smith, David] Agcy Sci Technol & Res, Singapore Inst Clin Sci, Singapore, Singapore.
   [Wagner, Karl-Heinz] Univ Vienna, Dept Nutr Sci, Vienna, Austria.
C3 University of Auckland; University of Vienna; University of Vienna;
   Medical University of Vienna; Kaiser-Franz-Josef Hospital; AgResearch -
   New Zealand; University of Otago; Agency for Science Technology &
   Research (A*STAR); A*STAR - Singapore Institute for Clinical Sciences
   (SICS); University of Vienna
RP Wagner, KH (corresponding author), Univ Vienna, Res Platform Act Ageing, Althanstr 14, A-1090 Vienna, Austria.; Wagner, KH (corresponding author), Univ Vienna, Dept Nutr Sci, Vienna, Austria.
EM karl-heinz.wagner@univie.ac.at
RI Roy, Nicole/AAP-5016-2020; Milan, Amber/I-5680-2019; Franzke,
   Bernhard/AEJ-8037-2022; Wagner, Karl-Heinz/B-9098-2013; Wessner,
   Barbara/J-8244-2012
OI Tosevska, Anela/0000-0002-0892-7068; Gillies,
   Nicola/0000-0002-1280-5725; Cameron-Smith, David/0000-0002-0144-5816;
   Franzke, Bernhard/0000-0001-6762-2777; Wagner,
   Karl-Heinz/0000-0002-1683-7265; Wessner, Barbara/0000-0002-9061-7914
FU University of Auckland; Hope Foundation
FX We thank the Curatorship of Viennese Retirement Homes and its residents
   for taking part in the study. We thank Dr Matthew Barnett for the
   coordination of the AgResearch Ltd Strategic Science Investment Fund.
   Nicola Gillies thanks Professor Clare Wall and Professor Richard Mithen
   for PhD supervision, and the University of Auckland and the Hope
   Foundation for scholarship support.
CR ALLEN RH, 1993, METABOLISM, V42, P1448, DOI 10.1016/0026-0495(93)90198-W
   Alves A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061356
   Andraos S, 2020, ANAL BIOCHEM, V592, DOI 10.1016/j.ab.2019.113558
   [Anonymous], 2015, Serum and red blood cell folate concentrations for assessing folate status in populations. Vitamin and Mineral Nutrition Information System
   Arnadottir M, 1996, SCAND J CLIN LAB INV, V56, P41, DOI 10.3109/00365519609088586
   Bae S, 2014, CANCER RES, V74, P7442, DOI 10.1158/0008-5472.CAN-14-1835
   Bates CJ, 1999, BRIT J NUTR, V81, P191, DOI 10.1017/S0007114599000380
   Björck J, 2006, METABOLISM, V55, P1007, DOI 10.1016/j.metabol.2006.03.010
   Bjorndal B, 2018, SCAND J CLIN LAB INV, V78, P527, DOI 10.1080/00365513.2018.1512716
   Bostom AG, 1997, KIDNEY INT, V52, P10, DOI 10.1038/ki.1997.298
   Brönstrup A, 1999, INT J VITAM NUTR RES, V69, P187, DOI 10.1024/0300-9831.69.3.187
   Cassilhas RC, 2007, MED SCI SPORT EXER, V39, P1401, DOI 10.1249/mss.0b013e318060111f
   Catena C, 2015, AM J HYPERTENS, V28, P943, DOI 10.1093/ajh/hpu248
   Cheng SS, 2012, CIRCULATION, V125, P2222, DOI 10.1161/CIRCULATIONAHA.111.067827
   Clarke R, 2002, JAMA-J AM MED ASSOC, V288, P2015, DOI 10.1001/jama.288.16.2015
   Silva ADE, 2014, AMINO ACIDS, V46, P1795, DOI 10.1007/s00726-014-1741-z
   Deminice R, 2015, AMINO ACIDS, V47, P839, DOI 10.1007/s00726-014-1913-x
   Dominguez Ligia J, 2007, J Cardiometab Syndr, V2, P183, DOI 10.1111/j.1559-4564.2007.06673.x
   Ejaz A, 2016, DIABETES, V65, P902, DOI 10.2337/db15-1094
   El-Khairy L, 2003, CLIN CHEM, V49, P113, DOI 10.1373/49.1.113
   Elshorbagy AK, 2008, AM J CLIN NUTR, V88, P738, DOI 10.1093/ajcn/88.3.738
   Elshorbagy AK, 2012, CURR OPIN CLIN NUTR, V15, P49, DOI 10.1097/MCO.0b013e32834d199f
   FOLSTEIN MF, 1975, J PSYCHIAT RES, V12, P189, DOI 10.1016/0022-3956(75)90026-6
   Franzke B, 2018, FREE RADICAL BIO MED, V121, P69, DOI 10.1016/j.freeradbiomed.2018.04.565
   Franzke B, 2015, EXP GERONTOL, V65, P16, DOI 10.1016/j.exger.2015.03.001
   Franzke B, 2015, MUTAGENESIS, V30, P147, DOI 10.1093/mutage/geu074
   Gahche JJ, 2017, J NUTR, V147, P1968, DOI 10.3945/jn.117.255984
   Garcin J. -M., 2006, Metabolic Syndrome and Related Disorders, V4, P185, DOI 10.1089/met.2006.4.185
   Gatterer G., 2004, MENTAL FITNESS AGING
   Hajer GR, 2007, HEART, V93, P216, DOI 10.1136/hrt.2006.093971
   Jacobs RL, 2005, J BIOL CHEM, V280, P28299, DOI 10.1074/jbc.M501971200
   Johnson Mary Ann, 2014, Journal of Nutrition in Gerontology and Geriatrics, V33, P1, DOI 10.1080/21551197.2014.875817
   Konstantinova SV, 2008, J NUTR, V138, P914, DOI 10.1093/jn/138.5.914
   Lever M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0021666
   Liu-Ambrose T, 2009, BRIT J SPORT MED, V43, P25, DOI 10.1136/bjsm.2008.055616
   Magnusson M, 2015, DIABETES, V64, P3010, DOI 10.2337/db14-1863
   Mathers JC, 2015, BRIT J NUTR, V113, pS18, DOI 10.1017/S0007114514003237
   McKay DL, 2000, J NUTR, V130, P3090, DOI 10.1093/jn/130.12.3090
   McLean E, 2008, FOOD NUTR BULL, V29, pS38, DOI 10.1177/15648265080292S107
   Mendis S, 2011, Global Atlas on Cardiovascular Disease Prevention and Control
   Morris MS, 2008, AM J CLIN NUTR, V87, P1446, DOI 10.1093/ajcn/87.5.1446
   Müllner E, 2013, MUTAGENESIS, V28, P205, DOI 10.1093/mutage/ges073
   Nelson ME, 2007, MED SCI SPORT EXER, V39, P1435, DOI 10.1249/mss.0b013e3180616aa2
   Nygård O, 1998, AM J CLIN NUTR, V67, P263, DOI 10.1093/ajcn/67.2.263
   Oesen S, 2015, EXP GERONTOL, V72, P99, DOI 10.1016/j.exger.2015.08.013
   Porter K, 2016, NUTRIENTS, V8, DOI 10.3390/nu8110725
   Qato DM, 2016, JAMA INTERN MED, V176, P473, DOI 10.1001/jamainternmed.2015.8581
   R Core Team, 2017, R: A Language and Environment for Statistical Computing
   Rhee EJ, 2007, ENDOCR J, V54, P995, DOI 10.1507/endocrj.K07E-018
   Roe AJ, 2017, AM J CLIN NUTR, V105, P1283, DOI 10.3945/ajcn.116.137158
   Schwab U, 2011, EUR J CLIN NUTR, V65, P70, DOI 10.1038/ejcn.2010.230
   SELHUB J, 1993, JAMA-J AM MED ASSOC, V270, P2693, DOI 10.1001/jama.270.22.2693
   Selhub J, 2002, J Nutr Health Aging, V6, P39
   Smith AD, 2016, ANNU REV NUTR, V36, P211, DOI 10.1146/annurev-nutr-071715-050947
   Strasser B, 2010, SPORTS MED, V40, P397, DOI 10.2165/11531380-000000000-00000
   Svingen GFT, 2016, CLIN CHEM, V62, P755, DOI 10.1373/clinchem.2015.250761
   Ueland PM, 2007, CLIN CHEM LAB MED, V45, P1737, DOI 10.1515/CCLM.2007.339
   UELAND PM, 1993, CLIN CHEM, V39, P1764
   United Nations Department of Economic and Social Affairs, 2020, WORLD POP AG 2019
   van Wijk N, 2012, BRIT J NUTR, V107, P1408, DOI 10.1017/S0007114511004570
   Vincent HK, 2006, OBESITY, V14, P1921, DOI 10.1038/oby.2006.224
   Vincent Kevin R, 2003, Prev Cardiol, V6, P197, DOI 10.1111/j.1520-037X.2003.01723.x
   Wang XC, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0096126
   Wei R, 2018, Sci Rep, V8, DOI [DOI 10.1038/S41598-017-19120-0, 10.1038/s41598-017-19120-0]
   Williams MA, 2007, CIRCULATION, V116, P572, DOI 10.1161/CIRCULATIONAHA.107.185214
   Yan J, 2012, NUTR DIABETES, V2, DOI 10.1038/nutd.2012.23
NR 66
TC 5
Z9 5
U1 0
U2 7
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD FEB
PY 2022
VL 61
IS 1
BP 169
EP 182
DI 10.1007/s00394-021-02607-y
EA JUL 2021
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA YL0UA
UT WOS:000670863900001
PM 34240265
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Takemori, K
   Yoshimoto, K
   Aoki, K
   Matsuo, T
   Kometani, T
AF Takemori, Kumiko
   Yoshimoto, Kaito
   Aoki, Kana
   Matsuo, Takuya
   Kometani, Takashi
TI Development of pups born to rats established as a model of underweight
   Japanese women and the onset of impaired glucose tolerance
SO BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Developmental Origins of Health and Disease; intrauterine environment;
   metabolic syndrome; rat model; undernutrition
ID PROTEIN RESTRICTION; UNDERNUTRITION; MUSCLE; PREGNANCY; GROWTH; FOXO1
AB An increasing number of Japanese women of childbearing age are underweight (BMI <18.5), but the association between this and the increased number of low-birth-weight babies born remains unclear. Here, a rat model was established to mimic the undernutrition (85% of the energy required for those with normal activity levels) experienced by such women and to evaluate the associated impaired glucose tolerance. The undernourished Wistar rat group showed increased serum corticosterone level reflecting stress, and greater adrenal weight and size. It also showed greater insulin resistance, higher expression of FOXO-1, a transcription factor related to muscle atrophy, and lower expression of p-Akt, an insulin-dependent signaling factor. Overall, this work shows the key role of undernutrition during pregnancy as a cause of impaired glucose tolerance and increased diabetes risk in offspring. The findings of this study may inform preemptive measures to prevent the development of metabolic syndrome in offspring of undernourished mothers.
C1 [Takemori, Kumiko; Kometani, Takashi] Kindai Univ, Fac Agr, Dept Food Sci & Nutr, Nara, Japan.
   [Takemori, Kumiko; Yoshimoto, Kaito; Aoki, Kana; Kometani, Takashi] Kindai Univ, Grad Sch Agr Sci, Dept Appl Biol Chem, Nara, Japan.
   [Matsuo, Takuya] Kindai Univ, Fac Med, Dept Arts & Sci, Osaka, Japan.
   [Kometani, Takashi] Pharma Foods Int Co Ltd, Kyoto, Japan.
C3 Kindai University (Kinki University); Kindai University (Kinki
   University); Kindai University (Kinki University)
RP Takemori, K (corresponding author), Kindai Univ, Fac Agr, Dept Food Sci & Nutr, Nara, Japan.; Takemori, K (corresponding author), Kindai Univ, Grad Sch Agr Sci, Dept Appl Biol Chem, Nara, Japan.
EM kuriman@nara.kindai.ac.jp
CR [Anonymous], About Us
   Beauchamp B, 2016, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00401
   Carter ME, 2007, CURR BIOL, V17, pR113, DOI 10.1016/j.cub.2007.01.008
   Desai M, 2007, AM J PHYSIOL-REG I, V293, pR2306, DOI 10.1152/ajpregu.00783.2006
   Lopes GAD, 2017, J MATERN-FETAL NEO M, V30, P722, DOI 10.1080/14767058.2016.1183635
   Gavete ML, 2005, ENDOCRINOLOGY, V146, P3368, DOI 10.1210/en.2004-1658
   Hales CN, 2001, BRIT MED BULL, V60, P5, DOI 10.1093/bmb/60.1.5
   Hanson MA, 2014, PHYSIOL REV, V94, P1027, DOI 10.1152/physrev.00029.2013
   Kousteni S, 2012, BONE, V50, P437, DOI 10.1016/j.bone.2011.06.034
   Kubota K, 2013, J OBSTET GYNAECOL RE, V39, P1383, DOI 10.1111/jog.12070
   Lesage J, 2001, ENDOCRINOLOGY, V142, P1692, DOI 10.1210/en.142.5.1692
   Lin XZ, 2019, J BONE MINER RES, V34, P1517, DOI 10.1002/jbmr.3731
   Muroya S, 2021, METABOLITES, V11, DOI 10.3390/metabo11090582
   Nahlé Z, 2008, J BIOL CHEM, V283, P14317, DOI 10.1074/jbc.M706478200
   Navarrete A, 2011, NATURE, V480, P91, DOI 10.1038/nature10629
   Nemoto T, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0238223
   Normile D, 2018, SCIENCE, V361, P440, DOI 10.1126/science.361.6401.440
   Otani L, 2004, BIOSCI BIOTECH BIOCH, V68, P488, DOI 10.1271/bbb.68.488
   Otani L, 2012, J NUTR BIOCHEM, V23, P892, DOI 10.1016/j.jnutbio.2011.04.014
   Palou M, 2010, NUTR METAB, V7, DOI 10.1186/1743-7075-7-69
   Roseboom TJ, 2011, MATURITAS, V70, P141, DOI 10.1016/j.maturitas.2011.06.017
   Takemori K, 2015, LIFE SCI, V120, P48, DOI 10.1016/j.lfs.2014.10.011
   Wang J, 2016, BRIT J NUTR, V116, P390, DOI 10.1017/S0007114516002166
   Yajnik CS, 2014, ANN NUTR METAB, V64, P8, DOI 10.1159/000362608
   You WJ, 2019, CURR PROTEIN PEPT SC, V20, P918, DOI 10.2174/1389203720666190624143503
NR 25
TC 0
Z9 0
U1 1
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0916-8451
EI 1347-6947
J9 BIOSCI BIOTECH BIOCH
JI Biosci. Biotechnol. Biochem.
PD JUN 25
PY 2022
VL 86
IS 7
BP 875
EP 883
DI 10.1093/bbb/zbac053
EA APR 2022
PG 9
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Chemistry, Applied; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Chemistry; Food Science & Technology
GA 2J3CD
UT WOS:000808213200001
PM 35404447
OA Bronze
DA 2025-06-11
ER

PT J
AU Lteif, C
   Ataya, A
   Duarte, JD
AF Lteif, Christelle
   Ataya, Ali
   Duarte, Julio D.
TI Therapeutic Challenges and Emerging Treatment Targets for Pulmonary
   Hypertension in Left Heart Disease
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Review
DE heart failure; mechanisms; pathophysiology; pulmonary hypertension;
   treatment
ID PRESERVED EJECTION FRACTION; SOLUBLE GUANYLATE-CYCLASE; LOOP-HELIX
   PROTEINS; ENDOTHELIN RECEPTOR ANTAGONISM; CAPILLARY WEDGE PRESSURE;
   DOUBLE-BLIND; ARTERIAL-HYPERTENSION; NITRIC-OXIDE; SEROTONIN
   TRANSPORTER; METABOLIC SYNDROME
AB Pulmonary hypertension (PH) attributable to left heart disease (LHD) is believed to be the most common form of PH and is strongly associated with increased mortality and morbidity in this patient population. Specific therapies for PH-LHD have not yet been identified and the use of pulmonary artery hypertension-targeted therapies in PH-LHD are not recommended. Endothelin receptor antagonists, phosphodiesterase-5 inhibitors, guanylate cyclase stimulators, and prostacyclins have all been studied in PH-LHD with conflicting results. Understanding the mechanisms underlying PH-LHD could potentially provide novel therapeutic targets. Fibrosis, oxidative stress, and metabolic syndrome have been proposed as pathophysiological components of PH-LHD. Genetic associations have also been identified, offering additional mechanisms with biological plausibility. This review summarizes the evidence and challenges for treatment of PH-LHD and focuses on underlying mechanisms on the horizon that could develop into potential therapeutic targets for this disease.
C1 [Lteif, Christelle; Duarte, Julio D.] Univ Florida, Coll Pharm, Dept Pharmacotherapy & Translat Res, Ctr Pharmacogen & Precis Med, Gainesville, FL USA.
   [Ataya, Ali] Univ Florida, Coll Med, Div Pulm Crit Care & Sleep Med, Gainesville, FL USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida
RP Duarte, JD (corresponding author), Univ Florida, Coll Pharm, HSC POB 100486,1600 SW Archer Rd, Gainesville, FL 32610 USA.
EM juliod@cop.ufl.edu
OI Duarte, Julio/0000-0001-9766-4038; Lteif,
   Christelle/0000-0002-0468-8936; Ataya, Ali/0000-0001-8505-1680
CR Abe JI, 2006, J MOL CELL CARDIOL, V41, P4, DOI 10.1016/j.yjmcc.2006.04.012
   Al-Kharrat T, 1999, AM J RESP CRIT CARE, V160, P415, DOI 10.1164/ajrccm.160.2.9808082
   Al-Naamani N, 2015, JACC-HEART FAIL, V3, P467, DOI 10.1016/j.jchf.2015.01.013
   Ambrosy AP, 2013, AM HEART J, V165, P216, DOI 10.1016/j.ahj.2012.11.004
   Anand I, 2004, LANCET, V364, P347, DOI 10.1016/S0140-6736(04)16723-8
   [Anonymous], 2021, J AM HEART ASSOC, V10, DOI [10.1161/JAHA.120.020633, DOI 10.1161/JAHA.120.020633]
   Armstrong PW, 2020, NEW ENGL J MED, V382, P1883, DOI 10.1056/NEJMoa1915928
   Arwood MJ, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-55700-y
   Assad TR, 2016, J AM COLL CARDIOL, V68, P2525, DOI 10.1016/j.jacc.2016.09.942
   Ayme-Dietrich E, 2017, ARCH CARDIOVASC DIS, V110, P51, DOI 10.1016/j.acvd.2016.08.002
   Barnes H, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD012621.pub2
   Behling A, 2008, J CARD FAIL, V14, P189, DOI 10.1016/j.cardfail.2007.11.006
   Belge C, 2014, CIRCULATION, V129, P451, DOI 10.1161/CIRCULATIONAHA.113.004940
   BENEZRA R, 1990, CELL, V61, P49, DOI 10.1016/0092-8674(90)90214-Y
   Bermejo J, 2018, EUR HEART J, V39, P1255, DOI 10.1093/eurheartj/ehx700
   Bonderman D, 2014, CHEST, V146, P1274, DOI 10.1378/chest.14-0106
   Bonderman D, 2013, CIRCULATION, V128, P502, DOI 10.1161/CIRCULATIONAHA.113.001458
   Bosch L, 2017, EUR J HEART FAIL, V19, P1664, DOI 10.1002/ejhf.873
   Bundgaard H, 2010, CIRCULATION, V122, P2699, DOI 10.1161/CIRCULATIONAHA.110.964619
   Burkhoff D., 2020, CIRCULATION, V142, pA15294
   Cai H, 2003, TRENDS PHARMACOL SCI, V24, P471, DOI 10.1016/S0165-6147(03)00233-5
   Califf RM, 1997, AM HEART J, V134, P44, DOI 10.1016/S0002-8703(97)70105-4
   Cappola TP, 2002, CIRCULATION, V105, P1663, DOI 10.1161/01.CIR.0000013771.30198.82
   Caravita S, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0199164
   CENGIZ M, 1983, CRIT CARE MED, V11, P502, DOI 10.1097/00003246-198307000-00004
   Chakravarti A, 2013, CELL, V155, P21, DOI 10.1016/j.cell.2013.09.001
   Chen L, 2001, J PHARMACOL EXP THER, V298, P469
   Chen SL, 2015, CIRC-CARDIOVASC INTE, V8, DOI 10.1161/CIRCINTERVENTIONS.115.002837
   Chen SL, 2013, J AM COLL CARDIOL, V62, P1092, DOI 10.1016/j.jacc.2013.05.075
   Chen SL, 2013, EUROINTERVENTION, V9, P269, DOI 10.4244/EIJV9I2A43
   Chen YJ, 2012, HYPERTENSION, V59, P1170, DOI 10.1161/HYPERTENSIONAHA.111.186072
   Clark CB, 2016, CARDIOL CLIN, V34, P401, DOI 10.1016/j.ccl.2016.04.010
   Cosby K, 2003, NAT MED, V9, P1498, DOI 10.1038/nm954
   Csiszar A, 2009, HYPERTENSION, V54, P668, DOI 10.1161/HYPERTENSIONAHA.109.133397
   De Vecchis R, 2018, MINERVA CARDIOANGIOL, V66, P659, DOI 10.23736/S0026-4725.17.04382-1
   Delgado JF, 2005, EUR J HEART FAIL, V7, P1011, DOI 10.1016/j.ejheart.2004.10.021
   DeMarco VG, 2008, AM J PHYSIOL-HEART C, V294, pH2659, DOI 10.1152/ajpheart.00953.2007
   Duarte JD, 2018, PULM CIRC, V8, DOI 10.1177/2045894018773049
   Dupont M, 2012, CIRC-HEART FAIL, V5, P778, DOI 10.1161/CIRCHEARTFAILURE.112.968511
   Eddahibi S, 2001, J CLIN INVEST, V108, P1141, DOI 10.1172/JCI200112805
   Estephan LE, 2019, PULM CIRC, V9, DOI 10.1177/2045894019840646
   Farahmand F, 2004, MOL CELL BIOCHEM, V260, P21
   Fayyaz AU, 2018, CIRCULATION, V137, P1796, DOI 10.1161/CIRCULATIONAHA.117.031608
   Forfia PR, 2012, CIRCULATION, V125, pE408, DOI 10.1161/CIRCULATIONAHA.111.064584
   Forrest S, 2004, ARTERIOSCL THROM VAS, V24, P2014, DOI 10.1161/01.ATV.0000143932.03151.ad
   Galiè N, 2019, EUR RESPIR J, V53, DOI 10.1183/13993003.02148-2018
   Galiè N, 2016, EUR HEART J, V37, P67, DOI 10.1093/eurheartj/ehv317
   Galiè N, 2009, EUR HEART J, V30, P2493, DOI 10.1093/eurheartj/ehp297
   García-Alvarez A, 2016, BASIC RES CARDIOL, V111, DOI 10.1007/s00395-016-0567-0
   Garcia-Lunar I, 2020, JACC-BASIC TRANSL SC, V5, P317, DOI 10.1016/j.jacbts.2020.01.009
   Gerges C, 2013, CHEST, V143, P758, DOI 10.1378/chest.12-1653
   Gerges M, 2015, AM J RESP CRIT CARE, V192, P1234, DOI 10.1164/rccm.201503-0529OC
   Ghasemzadeh N, 2014, HYPERTENSION, V63, P1270, DOI 10.1161/HYPERTENSIONAHA.113.02360
   Gheorghiade M, 2015, JAMA-J AM MED ASSOC, V314, P2251, DOI 10.1001/jama.2015.15734
   Ghio S, 2001, J AM COLL CARDIOL, V37, P183, DOI 10.1016/S0735-1097(00)01102-5
   GIAID A, 1993, NEW ENGL J MED, V328, P1732, DOI 10.1056/NEJM199306173282402
   Gladwin M, ORAL NITRITE PATIENT
   Guay CA, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204610
   Guazzi M, 2012, EUR J HEART FAIL, V14, P82, DOI 10.1093/eurjhf/hfr147
   Guazzi M, 2011, CIRCULATION, V124, P164, DOI 10.1161/CIRCULATIONAHA.110.983866
   Gupte SA, 2008, ANTIOXID REDOX SIGN, V10, P1137, DOI 10.1089/ars.2007.1995
   Halpern SD, 2009, CHEST, V136, P37, DOI 10.1378/chest.08-2784
   Hansen MS, 2018, PULM CIRC, V8, DOI 10.1177/2045894018790905
   Hemnes AR, 2017, CIRC RES, V121, P1136, DOI 10.1161/CIRCRESAHA.117.311737
   Hirata M, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/753210
   Hoendermis ES, 2015, EUR HEART J, V36, P2565, DOI 10.1093/eurheartj/ehv336
   Hoeper MM, 2016, JACC-HEART FAIL, V4, P441, DOI 10.1016/j.jchf.2015.12.016
   Hunter CJ, 2004, NAT MED, V10, P1122, DOI 10.1038/nm1109
   Hutcheson JD, 2011, PHARMACOL THERAPEUT, V132, P146, DOI 10.1016/j.pharmthera.2011.03.008
   Hwang IC, 2017, BMC CARDIOVASC DISOR, V17, DOI 10.1186/s12872-017-0576-4
   Iwanaga Y, 1998, CIRCULATION, V98, P2065, DOI 10.1161/01.CIR.98.19.2065
   Jiang R, 2015, HYPERTENS RES, V38, P829, DOI 10.1038/hr.2015.73
   JONES DA, 1995, MOL PHARMACOL, V48, P890
   Jones DP, 2006, ANTIOXID REDOX SIGN, V8, P1865, DOI 10.1089/ars.2006.8.1865
   Jones DP, 2000, FREE RADICAL BIO MED, V28, P625, DOI 10.1016/S0891-5849(99)00275-0
   Kaluski E, 2008, CARDIOLOGY, V109, P273, DOI 10.1159/000107791
   Kelly NJ, 2017, AM J RESP CELL MOL, V56, P488, DOI 10.1165/rcmb.2016-0176OC
   Klapholz M, 2004, J AM COLL CARDIOL, V43, P1432, DOI 10.1016/j.jacc.2003.11.040
   Lai YC, 2016, CIRCULATION, V133, P717, DOI 10.1161/CIRCULATIONAHA.115.018935
   Lakshminrusimha S, 2006, AM J RESP CRIT CARE, V174, P1370, DOI 10.1164/rccm.200605-676OC
   Lam CSP, 2009, J AM COLL CARDIOL, V53, P1119, DOI 10.1016/j.jacc.2008.11.051
   Leung CC, 2010, AM J CARDIOL, V106, P284, DOI 10.1016/j.amjcard.2010.02.039
   Lewis GD, 2007, CIRCULATION, V116, P1555, DOI 10.1161/CIRCULATIONAHA.107.716373
   Lowery JW, 2010, AM J PHYSIOL-REG I, V299, pR1463, DOI 10.1152/ajpregu.00866.2009
   Lüscher TF, 2002, CIRCULATION, V106, P2666, DOI 10.1161/01.CIR.0000038497.80095.E1
   Maddox TM, 2021, J AM COLL CARDIOL, V77, P772, DOI 10.1016/j.jacc.2020.11.022
   Massari ME, 2000, MOL CELL BIOL, V20, P429, DOI 10.1128/MCB.20.2.429-440.2000
   Matsa LS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0070523
   McLaughlin VV, 2009, J AM COLL CARDIOL, V53, P1573, DOI 10.1016/j.jacc.2009.01.004
   McNamara DM, 2003, CIRCULATION, V107, P1598, DOI 10.1161/01.CIR.0000060540.93836.AA
   Melenovsky V, 2014, EUR HEART J, V35, P3452, DOI 10.1093/eurheartj/ehu193
   Meng QQ, 2017, AM J RESP CELL MOL, V56, P497, DOI 10.1165/rcmb.2016-0177OC
   Meoli DF, 2018, PULM CIRC, V8, DOI 10.1177/2045893217745019
   Miller WL, 2013, JACC-HEART FAIL, V1, P290, DOI 10.1016/j.jchf.2013.05.001
   MIYAUCHI T, 1993, CIRC RES, V73, P887, DOI 10.1161/01.RES.73.5.887
   Moghaddam N, 2021, AM HEART J, V235, P74, DOI 10.1016/j.ahj.2021.01.003
   Montani D, 2010, RESP MED, V104, pS23, DOI 10.1016/j.rmed.2010.03.014
   Mulder P, 1997, CIRCULATION, V96, P1976, DOI 10.1161/01.CIR.96.6.1976
   Niu XL, 2012, J AM COLL CARDIOL, V59, P1979, DOI 10.1016/j.jacc.2011.12.046
   Olson TP, 2007, AM HEART J, V153, P426, DOI 10.1016/j.ahj.2006.12.011
   Omori Y, 2012, J HYPERTENS, V30, P1834, DOI 10.1097/HJH.0b013e3283569c5a
   Opitz CF, 2016, J AM COLL CARDIOL, V68, P368, DOI 10.1016/j.jacc.2016.05.047
   Packer M, 2005, J CARD FAIL, V11, P12, DOI 10.1016/j.cardfail.2004.05.006
   Packer M, 2017, JACC-HEART FAIL, V5, P317, DOI 10.1016/j.jchf.2017.02.021
   Palazzini M, 2018, EUR J HEART FAIL, V20, P248, DOI 10.1002/ejhf.860
   Patel PA, 2014, CIRC-HEART FAIL, V7, P918, DOI 10.1161/CIRCHEARTFAILURE.113.000872
   Patel RB, 2020, ESC HEART FAIL, V7, P254, DOI 10.1002/ehf2.12565
   Perk J, 2005, NAT REV CANCER, V5, P603, DOI 10.1038/nrc1673
   Pieske B, 2017, EUR HEART J, V38, P1119, DOI 10.1093/eurheartj/ehw593
   Ranchoux B, 2019, CIRC RES, V125, P449, DOI 10.1161/CIRCRESAHA.118.314555
   Redfield MM, 2013, JAMA-J AM MED ASSOC, V309, P1268, DOI 10.1001/jama.2013.2024
   Rich S, 2003, CIRCULATION, V108, P2184, DOI 10.1161/01.CIR.0000094397.19932.78
   Robbins IM, 2009, CHEST, V136, P31, DOI 10.1378/chest.08-2008
   Rosenkranz S, 2016, EUR HEART J, V37, P942, DOI 10.1093/eurheartj/ehv512
   Ryan JJ, 2012, AM HEART J, V163, P589, DOI 10.1016/j.ahj.2012.01.024
   Sato N, 2010, DIABETES, V59, P1092, DOI 10.2337/db09-1432
   Schwartzenberg S, 2012, J AM COLL CARDIOL, V59, P442, DOI 10.1016/j.jacc.2011.09.062
   Shah AM, 2014, CIRC-HEART FAIL, V7, P104, DOI 10.1161/CIRCHEARTFAILURE.113.000887
   Simon MA, 2016, JCI INSIGHT, V1, DOI 10.1172/jci.insight.89620
   Simonneau G, 2002, AM J RESP CRIT CARE, V165, P800, DOI 10.1164/ajrccm.165.6.2106079
   Stasch JP, 2011, CIRCULATION, V123, P2263, DOI 10.1161/CIRCULATIONAHA.110.981738
   Stevens GR, 2012, JACC-CARDIOVASC IMAG, V5, P378, DOI 10.1016/j.jcmg.2011.11.020
   Strange G, 2012, HEART, V98, P1805, DOI 10.1136/heartjnl-2012-301992
   Tantini B, 2005, BASIC RES CARDIOL, V100, P131, DOI 10.1007/s00395-004-0504-5
   Tenax Therapeutics Inc., OP LAB ROLL STUD LEV
   Thenappan T, 2011, CIRC-HEART FAIL, V4, P257, DOI 10.1161/CIRCHEARTFAILURE.110.958801
   Tonelli AR, 2011, CHEST, V139, P115, DOI 10.1378/chest.10-0981
   Ulrich S, 2010, RESPIRATION, V79, P288, DOI 10.1159/000226243
   Vachiéry JL, 2019, EUR RESPIR J, V53, DOI 10.1183/13993003.01897-2018
   Vachiery JL, 2018, EUR RESPIR J, V51, DOI 10.1183/13993003.01886-2017
   Vachiéry JL, 2013, J AM COLL CARDIOL, V62, pD100, DOI 10.1016/j.jacc.2013.10.033
   Vaduganathan M, 2015, CIRC-HEART FAIL, V8, P826, DOI 10.1161/CIRCHEARTFAILURE.115.002271
   Veldman BA, 2002, J HYPERTENS, V20, P2023, DOI 10.1097/00004872-200210000-00022
   Wang LF, 2020, ARTERIOSCL THROM VAS, V40, P1543, DOI 10.1161/ATVBAHA.119.313883
   Wang Zhijie, 2011, Pulm Circ, V1, P212, DOI 10.4103/2045-8932.83453
   Weitsman T, 2017, AM J MED, V130, P1272, DOI 10.1016/j.amjmed.2017.05.003
   Wharton J, 2005, AM J RESP CRIT CARE, V172, P105, DOI 10.1164/rccm.200411-1587OC
   WILLIAMS GH, 1994, KIDNEY INT, V46, P1550, DOI 10.1038/ki.1994.443
   Wu XJ, 2014, EUR J HEART FAIL, V16, P444, DOI 10.1002/ejhf.47
   Yamauchi-Kohno R, 1999, CIRCULATION, V99, P2171, DOI 10.1161/01.CIR.99.16.2171
   Yancy CW, 2017, CIRCULATION, V136, pE137, DOI [10.1161/CIR.0000000000000509, 10.1016/j.cardfail.2017.04.014]
   Yancy CW, 2013, CIRCULATION, V128, P1810, DOI 10.1161/CIR.0b013e31829e8807
   Yang J, 2008, CIRC RES, V102, P1212, DOI 10.1161/CIRCRESAHA.108.173567
   Yang J, 2013, AM J PHYSIOL-LUNG C, V305, pL312, DOI 10.1152/ajplung.00054.2013
   Zhang H, 2019, PULM CIRC, V9, DOI 10.1177/2045894018816297
   Zhang H, 2019, JACC-CARDIOVASC INTE, V12, P274, DOI 10.1016/j.jcin.2018.09.021
NR 146
TC 17
Z9 17
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD JUN 1
PY 2021
VL 10
IS 11
AR e020633
DI 10.1161/JAHA.120.020633
PG 19
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA SK8OB
UT WOS:000656475800016
PM 34032129
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Barrera, M
   Hiriart, M
   Cocho, G
   Villarreal, C
AF Barrera, M.
   Hiriart, M.
   Cocho, G.
   Villarreal, C.
TI Type 2 diabetes progression: A regulatory network approach
SO CHAOS
LA English
DT Article
ID THIOREDOXIN-INTERACTING PROTEIN; BETA-CELL FAILURE; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; MATHEMATICAL-MODEL; SIGNALING PATHWAYS; IONIC
   CHANNELS; CA2+ IONS; GLUCOSE; INFLAMMATION
AB In order to elucidate central elements underlying type 2 diabetes, we constructed a regulatory network model involving 37 components (molecules, receptors, processes, etc.) associated to signaling pathways of pancreatic beta-cells. In a first approximation, the network topology was described by Boolean rules whose interacting dynamics predicted stationary patterns broadly classified as health, metabolic syndrome, and diabetes stages. A subsequent approximation based on a continuous logic analysis allowed us to characterize the progression of the disease as transitions between these states associated to alterations of cell homeostasis due to exhaustion or exacerbation of specific regulatory signals. The method allowed the identification of key transcription factors involved in metabolic stress as essential for the progression of the disease. Integration of the present analysis with existent mathematical models designed to yield accurate account of experimental data in human or animal essays leads to reliable predictions for beta-cell mass, insulinemia, glycemia, and glycosylated hemoglobin in diabetic fatty rats.
C1 [Barrera, M.] Univ Nacl Autonoma Mexico, Inst Ecol, Mexico City 04510, DF, Mexico.
   [Hiriart, M.] Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Mexico City 04510, DF, Mexico.
   [Cocho, G.; Villarreal, C.] Univ Nacl Autonoma Mexico, Inst Fis, Mexico City 04510, DF, Mexico.
   [Hiriart, M.; Cocho, G.; Villarreal, C.] Univ Nacl Autonoma Mexico, Ctr Ciencias Complejidad, Mexico City 04510, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma
   de Mexico; Universidad Nacional Autonoma de Mexico; Universidad Nacional
   Autonoma de Mexico
RP Villarreal, C (corresponding author), Univ Nacl Autonoma Mexico, Inst Fis, Mexico City 04510, DF, Mexico.
EM carlos@fisica.unam.mx
RI Villarreal, Carlos/D-7530-2016; Hiriart, Marcia/A-3988-2008
OI Villarreal, Carlos/0000-0003-3569-2820; Barrera,
   Maria/0000-0002-4232-6258; Hiriart, Marcia/0000-0001-5711-8868
FU CONACYT [379165]; Project CONACYT [180381]; Centro de Ciencias de la
   Complejidad, UNAM
FX M.B., M.H., and C.V. acknowledge the enormous intellectual influence and
   teachings of G. Cocho, co-author of this paper, who passed away during
   the elaboration of this work. We also acknowledge valuable comments of
   C. F. Bunge. M.B. is a Ph.D. student from Programa de Doctorado en
   Ciencias Biomedicas, Universidad Nacional Autonoma de Mexico (UNAM) and
   received Fellowship (No. 379165) from CONACYT. C.V. acknowledges
   financial support from Project CONACYT (No. 180381). All authors
   acknowledge support from Centro de Ciencias de la Complejidad, UNAM.
CR Ahrén B, 2006, DIABETES, V55, pS98, DOI 10.2337/db06-S013
   Ahrén B, 2012, J DIABETES INVEST, V3, P3, DOI 10.1111/j.2040-1124.2011.00184.x
   Ajmera I, 2013, CPT-PHARMACOMET SYST, V2, DOI 10.1038/psp.2013.30
   Albert R, 2014, WIRES SYST BIOL MED, V6, P353, DOI 10.1002/wsbm.1273
   Alhawiti NM, 2017, CURR DRUG TARGETS, V18, P1095, DOI 10.2174/1389450118666170130145514
   Guzmán MA, 2015, NUTR HOSP, V31, P1129, DOI 10.3305/nh.2015.31.3.7955
   [Anonymous], 2014, J Diabetes Res, DOI DOI 10.1155/2014/795171
   Baggio LL, 2007, GASTROENTEROLOGY, V132, P2131, DOI 10.1053/j.gastro.2007.03.054
   Cedersund G, 2009, EUR J PHARM SCI, V36, P91, DOI 10.1016/j.ejps.2008.10.027
   Chen YN, 2013, TRENDS CELL BIOL, V23, P547, DOI 10.1016/j.tcb.2013.06.005
   Chiu YC, 2012, DIABETOLOGIA, V55, P3252, DOI 10.1007/s00125-012-2699-6
   Dandona P, 2004, TRENDS IMMUNOL, V25, P4, DOI 10.1016/j.it.2003.10.013
   Davila-Velderrain J, 2015, BMC SYST BIOL, V9, DOI 10.1186/s12918-015-0166-y
   De Gaetano A, 2008, AM J PHYSIOL-ENDOC M, V295, pE1462, DOI 10.1152/ajpendo.90444.2008
   de Laat MA, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00120
   Donath MY, 2011, NAT REV IMMUNOL, V11, P98, DOI 10.1038/nri2925
   Dubois D, 1997, J MATH ANAL APPL, V205, P359, DOI 10.1006/jmaa.1997.5193
   Enciso J, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.01927
   Fang DH, 2012, MOL MED REP, V5, P233, DOI 10.3892/mmr.2011.607
   G. Roglic, 2016, FUEL CELLS B, V1, P3, DOI 10.4103/2468-8827.184853
   Garay-Malpartida HM, 2011, BMC IMMUNOL, V12, DOI 10.1186/1471-2172-12-18
   GLASS L, 1973, J THEOR BIOL, V39, P103, DOI 10.1016/0022-5193(73)90208-7
   GLASS L, 1975, J THEOR BIOL, V54, P85, DOI 10.1016/S0022-5193(75)80056-7
   Guilherme A, 2008, NAT REV MOL CELL BIO, V9, P367, DOI 10.1038/nrm2391
   Ha J, 2016, ENDOCRINOLOGY, V157, P624, DOI 10.1210/en.2015-1564
   HAKEN H, 1975, REV MOD PHYS, V47, P67, DOI 10.1103/RevModPhys.47.67
   Haken Hermann., 1978, Synergetics, P191, DOI DOI 10.1007/978-3-642-96469-5
   Hardy T, 2012, AM J PHYSIOL-ENDOC M, V303, pE200, DOI 10.1152/ajpendo.00421.2011
   HENRY C, 2015, NAT REV DIS PRIMERS, P1
   Hernández-Hernández V, 2018, PHYS BIOL, V15, DOI 10.1088/1478-3975/aaac99
   Hetz C, 2012, NAT REV MOL CELL BIO, V13, P89, DOI 10.1038/nrm3270
   Hiriart M, 2014, VITAM HORM, V95, P87, DOI 10.1016/B978-0-12-800174-5.00004-1
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Jayashree B, 2014, MOL CELL BIOCHEM, V388, P203, DOI 10.1007/s11010-013-1911-4
   Kadowaki H, 2013, GENES-BASEL, V4, P306, DOI 10.3390/genes4030306
   KAUFFMAN SA, 1969, J THEOR BIOL, V22, P437, DOI 10.1016/0022-5193(69)90015-0
   Kitamura T, 2007, ENDOCR J, V54, P507, DOI 10.1507/endocrj.KR-109
   Koh DS, 2012, J MOL NEUROSCI, V48, P429, DOI 10.1007/s12031-012-9752-2
   Kops GJPL, 2000, J ANAT, V197, P571, DOI 10.1046/j.1469-7580.2000.19740571.x
   KOSKO B, 1990, INT J GEN SYST, V17, P211, DOI 10.1080/03081079008935108
   Le Novère N, 2015, NAT REV GENET, V16, P146, DOI 10.1038/nrg3885
   Leclerc I, 2012, J ENDOCRINOL, V213, P115, DOI 10.1530/JOE-11-0480
   Lee J, 2014, J BIOL CHEM, V289, P1203, DOI 10.1074/jbc.R113.534743
   Leibiger IB, 2002, FEBS LETT, V532, P1, DOI 10.1016/S0014-5793(02)03627-X
   Leibowitz G., 2014, Medicographia, V36, P391
   Lerner AG, 2012, CELL METAB, V16, P250, DOI 10.1016/j.cmet.2012.07.007
   Lusis AJ, 2008, NAT REV GENET, V9, P819, DOI 10.1038/nrg2468
   Martinez SC, 2006, DIABETES, V55, P1581, DOI 10.2337/db05-0678
   Martinez-Sanchez ME, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00877
   Méndez A, 2016, PLOS COMPUT BIOL, V12, DOI 10.1371/journal.pcbi.1004696
   Mendoza L, 2006, THEOR BIOL MED MODEL, V3, DOI 10.1186/1742-4682-3-13
   Mendoza L, 2015, BIOSYSTEMS, V137, P26, DOI 10.1016/j.biosystems.2015.09.004
   Muoio DM, 2008, NAT REV MOL CELL BIO, V9, P193, DOI 10.1038/nrm2327
   Nolan CJ, 2006, DIABETES, V55, pS16, DOI 10.2337/db06-S003
   Noordeen NA, 2012, DIABETES, V61, P574, DOI 10.2337/db10-1329
   Nyman E, 2016, INTERFACE FOCUS, V6, DOI 10.1098/rsfs.2015.0075
   Nyman E, 2014, J BIOL CHEM, V289, P33215, DOI 10.1074/jbc.M114.608927
   Nyman E, 2012, TRENDS ENDOCRIN MET, V23, P107, DOI 10.1016/j.tem.2011.12.007
   Nyman E, 2011, J BIOL CHEM, V286, P26028, DOI 10.1074/jbc.M110.188987
   Palumbo P, 2013, MATH BIOSCI, V244, P69, DOI 10.1016/j.mbs.2013.05.006
   Phillips LK, 2011, ANN NY ACAD SCI, V1243, P1, DOI 10.1111/j.1749-6632.2012.06491.x
   Piperi C, 2016, TRENDS ENDOCRIN MET, V27, P119, DOI 10.1016/j.tem.2016.01.001
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Pradhan G, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-00888-0
   Prana V, 2019, COMPUT MATH METHOD M, V2019, DOI 10.1155/2019/7525834
   Prentki M, 2006, J CLIN INVEST, V116, P1802, DOI 10.1172/JCI29103
   Prentki M, 2013, CELL METAB, V18, P162, DOI 10.1016/j.cmet.2013.05.018
   Rask-Madsen C, 2012, ARTERIOSCL THROM VAS, V32, P2052, DOI 10.1161/ATVBAHA.111.241919
   Shalev A, 2014, MOL ENDOCRINOL, V28, P1211, DOI 10.1210/me.2014-1095
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Stolarczyk E, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0001288
   Sweatman CZWH, 2020, J THEOR BIOL, V486, DOI 10.1016/j.jtbi.2019.110037
   Taniguchi CM, 2006, NAT REV MOL CELL BIO, V7, P85, DOI 10.1038/nrm1837
   Thorens B, 2015, DIABETOLOGIA, V58, P221, DOI 10.1007/s00125-014-3451-1
   Tong J, 2016, J CLIN ENDOCR METAB, V101, P2405, DOI 10.1210/jc.2015-4154
   Topp B, 2000, J THEOR BIOL, V206, P605, DOI 10.1006/jtbi.2000.2150
   Topp BB, 2004, DIABETOLOGIA, V47, P1602, DOI 10.1007/s00125-004-1493-5
   Topp BG, 2007, AM J PHYSIOL-ENDOC M, V293, pE1730, DOI 10.1152/ajpendo.00572.2007
   Tuttle RL, 2001, NAT MED, V7, P1133, DOI 10.1038/nm1001-1133
   Usui M, 2012, METABOLISM, V61, P1118, DOI 10.1016/j.metabol.2012.01.004
   Velasco M, 2016, MOL PHARMACOL, V90, P341, DOI 10.1124/mol.116.103861
   Velasco M, 2012, ISLETS, V4, P302, DOI 10.4161/isl.21374
   Villarreal C, 2012, PHYS REV LETT, V109, DOI 10.1103/PhysRevLett.109.118102
   Vives-Pi M, 2003, CLIN EXP IMMUNOL, V133, P208, DOI 10.1046/j.1365-2249.2003.02211.x
   Walter P, 2011, SCIENCE, V334, P1081, DOI 10.1126/science.1209038
   Wang RS, 2012, PHYS BIOL, V9, DOI 10.1088/1478-3975/9/5/055001
   Xu GL, 2013, NAT MED, V19, P1141, DOI 10.1038/nm.3287
   Xu GL, 2012, DIABETES, V61, P848, DOI 10.2337/db11-0955
   ZADEH LA, 1965, INFORM CONTROL, V8, P338, DOI 10.1016/S0019-9958(65)90241-X
NR 90
TC 3
Z9 3
U1 1
U2 5
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 1054-1500
EI 1089-7682
J9 CHAOS
JI Chaos
PD SEP
PY 2020
VL 30
IS 9
AR 093132
DI 10.1063/5.0011125
PG 13
WC Mathematics, Applied; Physics, Mathematical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Mathematics; Physics
GA NU8ZQ
UT WOS:000573926300005
PM 33003944
DA 2025-06-11
ER

PT J
AU Kolka, CM
   Bergman, RN
AF Kolka, Cathryn M.
   Bergman, Richard N.
TI The endothelium in diabetes: Its role in insulin access and diabetic
   complications
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Article
DE Diabetes; Endothelium; Insulin; Interstitium; Muscle; Vascular
ID ACTIVATED RECEPTOR-GAMMA; SKELETAL-MUSCLE; IN-VIVO; ADIPOSE-TISSUE;
   NITRIC-OXIDE; PHYSIOLOGICAL HYPERINSULINEMIA; GLOMERULAR ENDOTHELIUM;
   METABOLIC SYNDROME; OXIDATIVE STRESS; GLUCOSE-UPTAKE
AB The vascular endothelium has been identified as an important component in diabetes-associated complications, which include many cardiovascular disorders such as atherosclerosis, hypertension and peripheral neuropathy. Additionally, insulin's actions on the endothelium are now seen as a major factor in the metabolic effects of the hormone by increasing access to insulin sensitive tissues. Endothelial function is impaired in diabetes, obesity, and the metabolic syndrome, which could reduce insulin access to the tissue, and thus reduce insulin sensitivity independently of direct effects at the muscle cell. As such, the endothelium is a valid target for treatment of both the impaired glucose metabolism in diabetes, as well as the vascular based complications of diabetes. Here we review the basics of the endothelium in insulin action, with a focus on the skeletal muscle as insulin's major metabolic organ, and how this is affected by diabetes. We will focus on the most recent developments in the field, including current treatment possibilities.
C1 [Kolka, Cathryn M.; Bergman, Richard N.] Cedars Sinai Med Ctr, Dept Biomed Sci, Diabet & Obes Res Inst, Los Angeles, CA 90048 USA.
C3 Cedars Sinai Medical Center
RP Kolka, CM (corresponding author), Cedars Sinai Med Ctr, Dept Biomed Sci, Diabet & Obes Res Inst, 8700 Beverly Blvd,THAL E104, Los Angeles, CA 90048 USA.
EM Cathryn.Kolka@cshs.org
RI Bergman, Richard/B-9894-2013; Kolka, Cathryn/B-1526-2015
OI Kolka, Cathryn/0000-0002-6636-7062; Bergman, Richard/0000-0003-1539-4471
FU National Institutes of Health [DK27619, DK29867]
FX This work was supported by two National Institutes of Health grants,
   DK27619 and DK29867.
CR ADER M, 1994, AM J PHYSIOL, V266, pE17, DOI 10.1152/ajpendo.1994.266.1.E17
   [Anonymous], 2011, National Diabetes Fact Sheet: National Estimates and General Information on Diabetes and Prediabetes in the United States, 2011
   Barrett EJ, 2012, DIABETES, V61, P2661, DOI 10.2337/db12-0271
   Barrett EJ, 2011, AM J PHYSIOL-ENDOC M, V301, pE252, DOI 10.1152/ajpendo.00186.2011
   Brunner F, 1998, DIABETES, V47, P1127, DOI 10.2337/diabetes.47.7.1127
   Chai WD, 2012, DIABETES, V61, P888, DOI 10.2337/db11-1073
   Chai WD, 2011, DIABETES, V60, P2939, DOI 10.2337/db10-1691
   Chiu JD, 2008, DIABETES, V57, P828, DOI 10.2337/db07-1444
   Chiu JD, 2009, OBESITY, V17, P1486, DOI 10.1038/oby.2009.165
   Dimitriadis G, 2011, DIABETES RES CLIN PR, V93, pS52, DOI 10.1016/S0168-8227(11)70014-6
   El Akoum S, 2012, J ATHEROSCLER THROMB, V19, P1128, DOI 10.5551/jat.13482
   Ellmerer M, 2004, DIABETES, V53, P2741, DOI 10.2337/diabetes.53.11.2741
   Erdogdu Ö, 2010, MOL CELL ENDOCRINOL, V325, P26, DOI 10.1016/j.mce.2010.04.022
   Eringa EC, 2002, CARDIOVASC RES, V56, P464, DOI 10.1016/S0008-6363(02)00593-X
   Exalto LG, 2012, EXP GERONTOL, V47, P858, DOI 10.1016/j.exger.2012.07.014
   Fan YF, 2010, ANN NEUROL, V67, P488, DOI 10.1002/ana.21919
   Farb MG, 2012, ARTERIOSCL THROM VAS, V32, P467, DOI 10.1161/ATVBAHA.111.235846
   Florey, 1966, Br Med J, V2, P487
   Forst T, 2012, EXP DIABETES RES, DOI 10.1155/2012/635472
   Gealekman O, 2012, DIABETOLOGIA, V55, P2794, DOI 10.1007/s00125-012-2658-2
   Georgescu A, 2011, WORLD J DIABETES, V2, P92, DOI 10.4239/wjd.v2.i6.92
   Goldfine AB, 2006, J AM COLL CARDIOL, V47, P2456, DOI 10.1016/j.jacc.2006.02.045
   Iwata NG, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0029600
   Jonk AM, 2011, MICROVASC RES, V82, P77, DOI 10.1016/j.mvr.2011.04.002
   Jujo K, 2010, P NATL ACAD SCI USA, V107, P11008, DOI 10.1073/pnas.0914248107
   Kim JY, 2010, CELL TRANSPLANT, V19, P1635, DOI 10.3727/096368910X516637
   Kodera R, 2011, DIABETOLOGIA, V54, P965, DOI 10.1007/s00125-010-2028-x
   Kolka CM, 2012, PHYSIOLOGY, V27, P237, DOI 10.1152/physiol.00012.2012
   Kolka CM, 2009, DIABETES, V58, pA68
   Kubota T, 2011, CELL METAB, V13, P294, DOI 10.1016/j.cmet.2011.01.018
   Liu J, 2011, J CLIN ENDOCR METAB, V96, P438, DOI 10.1210/jc.2010-1174
   Majumdar S, 2012, DIABETOLOGIA, V55, P450, DOI 10.1007/s00125-011-2343-x
   Mima A, 2012, DIABETES, V61, P2967, DOI 10.2337/db11-1824
   Muniyappa R, 2013, MOL CELL ENDOCRINOL, V378, P59, DOI 10.1016/j.mce.2012.05.017
   Murrow JR, 2012, J CLIN LIPIDOL, V6, P42, DOI 10.1016/j.jacl.2011.08.006
   Natali A, 2004, ENDOCRIN METAB CLIN, V33, P417, DOI 10.1016/j.ecl.2004.03.007
   Omae T, 2011, INVEST OPHTH VIS SCI, V52, P6749, DOI 10.1167/iovs.10-6826
   Pershadsingh HA, 2006, INT J BIOCHEM CELL B, V38, P766, DOI 10.1016/j.biocel.2005.08.006
   Rask-Madsen C, 2010, CELL METAB, V11, P379, DOI 10.1016/j.cmet.2010.03.013
   Rattigan S, 2006, CURR DIABETES REV, V2, P61, DOI 10.2174/157339906775473653
   Sandqvist M, 2011, J CLIN ENDOCR METAB, V96, pE1320, DOI 10.1210/jc.2011-0233
   Satchell SC, 2012, KIDNEY INT, V82, P949, DOI 10.1038/ki.2012.258
   Serné EH, 2002, DIABETES, V51, P1515, DOI 10.2337/diabetes.51.5.1515
   Sgarra L, 2012, AM J PHYSIOL-ENDOC M, V302, pE1171, DOI 10.1152/ajpendo.00038.2012
   Sharma A, 2012, INT J VASC MED, V2012, DOI 10.1155/2012/750126
   Shenouda SM, 2011, CIRCULATION, V124, P444, DOI 10.1161/CIRCULATIONAHA.110.014506
   Sjöstrand M, 1999, AM J PHYSIOL-ENDOC M, V276, pE151, DOI 10.1152/ajpendo.1999.276.1.E151
   Steil GM, 1996, J CLIN INVEST, V97, P1497, DOI 10.1172/JCI118572
   Tack CJJ, 1996, EUR J CLIN INVEST, V26, P772, DOI 10.1046/j.1365-2362.1996.2020551.x
   Taguchi K, 2012, PHARMACOL RES, V66, P41, DOI 10.1016/j.phrs.2012.02.010
   Tian XY, 2011, BRIT J PHARMACOL, V164, P598, DOI 10.1111/j.1476-5381.2011.01416.x
   Tocci G, 2011, AM J HYPERTENS, V24, P582, DOI 10.1038/ajh.2011.8
   Tremolada G, 2012, EXP DIABETES RES, DOI 10.1155/2012/728325
   Utsunomiya K, 2012, VASC HEALTH RISK MAN, V8, P429, DOI 10.2147/VHRM.S32357
   van der Zijl NJ, 2011, DIABETES CARE, V34, P845, DOI 10.2337/dc10-2224
   Verma S, 2001, HYPERTENSION, V37, P328, DOI 10.1161/01.HYP.37.2.328
   Vicent D, 2003, J CLIN INVEST, V111, P1373, DOI 10.1172/JCI200315211
   Villela NR, 2009, ARQ BRAS ENDOCRINOL, V53, P238, DOI 10.1590/S0004-27302009000200015
   Vincent MA, 2004, DIABETES, V53, P1418, DOI 10.2337/diabetes.53.6.1418
   Wang H, 2006, AM J PHYSIOL-ENDOC M, V291, pE323, DOI 10.1152/ajpendo.00047.2006
   Wang H, 2011, AM J PHYSIOL-ENDOC M, V300, pE134, DOI 10.1152/ajpendo.00498.2010
   Yoon JS, 2011, DIABETES METAB J, V35, P437, DOI 10.4093/dmj.2011.35.5.437
   Yudkin JS, 2005, LANCET, V365, P1817, DOI 10.1016/S0140-6736(05)66585-3
NR 63
TC 45
Z9 51
U1 0
U2 24
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1389-9155
EI 1573-2606
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD MAR
PY 2013
VL 14
IS 1
BP 13
EP 19
DI 10.1007/s11154-012-9233-5
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 098SC
UT WOS:000315568000003
PM 23306780
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Moreto, F
   de Oliveira, EP
   Manda, RM
   Burini, RC
AF Moreto, Fernando
   de Oliveira, Erick P.
   Manda, Rodrigo M.
   Burini, Roberto C.
TI The Higher Plasma Malondialdehyde Concentrations Are Determined by
   Metabolic Syndrome-Related Glucolipotoxicity
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID GAMMA-GLUTAMYL-TRANSFERASE; SUGAR-SWEETENED BEVERAGES;
   CARDIOVASCULAR-DISEASE; LIPID-PEROXIDATION; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; OBESITY; BIOCHEMISTRY; CHEMISTRY; RISK
AB This study aimed to elucidate the determinants of higher plasma malondialdehyde (MDA) in free-living adults. In a cross-sectional study we evaluated 148 free-living subjects (54 +/- 11 years, 78% women) at high risk for or with metabolic syndrome (MetS). They were assessed by anthropometry and body composition, dietary intake, and clinical and laboratorial analysis. The analysis of plasma MDA was performed by HPLC, and concentration values were used to provide four groups according to percentile distribution. Subjects with higher plasma MDA showed higher prevalence of MetS and higher values of waist circumference (WC), glucose, triglycerides (TG), gamma-glutamyltransferase (gamma-GT), and higher energy intake. Multiadjusted logistic regression analysis identified as determinants of higher plasma MDA the altered values of WC and gamma-GT followed by hypertriglyceridemia, hyperglycemia, insulin resistance, higher dietary sugar-intake, and presence of MetS. In conclusion, the glucolipotoxic state predisposed by the presence of MetS seems to be the major determinant of higher plasma MDA concentrations.
C1 [Moreto, Fernando; de Oliveira, Erick P.; Manda, Rodrigo M.; Burini, Roberto C.] Sao Paulo State Univ, Botucatu Sch Med, Ctr Nutr & Exercise Metab CeMENutri, Botucatu, SP, Brazil.
   [de Oliveira, Erick P.] Univ Fed Uberlandia, Sch Med, BR-38400 Uberlandia, MG, Brazil.
C3 Universidade Estadual Paulista; Universidade Federal de Uberlandia
RP Moreto, F (corresponding author), Sao Paulo State Univ, Botucatu Sch Med, Ctr Nutr & Exercise Metab CeMENutri, Botucatu, SP, Brazil.
EM fer_moreto@yahoo.com.br
RI de Oliveira, Erick/D-1138-2011; Moreto, Fernando/I-7690-2013
OI Moreto, Fernando/0000-0002-4028-0014; P. de Oliveira,
   Erick/0000-0001-8989-8344
FU CAPES; CNPq
FX The authors thank CAPES and CNPq for the financial support.
CR Ahmed FN, 2006, ANN NY ACAD SCI, V1084, P481, DOI 10.1196/annals.1372.022
   BALKE B, 1959, U S Armed Forces Med J, V10, P675
   Blackburn P, 2012, METABOLISM, V61, P56, DOI 10.1016/j.metabol.2011.05.017
   Cinti S, 2005, J LIPID RES, V46, P2347, DOI 10.1194/jlr.M500294-JLR200
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Després JP, 2012, CAN J CARDIOL, V28, P642, DOI 10.1016/j.cjca.2012.06.004
   Drozdz R, 1998, FREE RADICAL BIO MED, V25, P786, DOI 10.1016/S0891-5849(98)00127-0
   Dupuy AM, 2007, GERONTOLOGY, V53, P329, DOI 10.1159/000103555
   Elokda AS, 2007, EUR J CARDIOV PREV R, V14, P630, DOI 10.1097/HJR.0b013e32828622d7
   ESTERBAUER H, 1991, FREE RADICAL BIO MED, V11, P81, DOI 10.1016/0891-5849(91)90192-6
   Goldin A, 2006, CIRCULATION, V114, P597, DOI 10.1161/CIRCULATIONAHA.106.621854
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Guéraud F, 2010, FREE RADICAL RES, V44, P1098, DOI 10.3109/10715762.2010.498477
   Hu FB, 2010, PHYSIOL BEHAV, V100, P47, DOI 10.1016/j.physbeh.2010.01.036
   Janssen I, 2000, J APPL PHYSIOL, V89, P465, DOI 10.1152/jappl.2000.89.2.465
   Johnson RK, 2009, CIRCULATION, V120, P1011, DOI 10.1161/CIRCULATIONAHA.109.192627
   Kawamoto R, 2011, ENDOCR RES, V36, P64, DOI 10.3109/07435800.2010.534756
   Kawamoto R, 2009, J ATHEROSCLER THROMB, V16, P355, DOI 10.5551/jat.No414
   KENNEDY E, 1995, AM J CLIN NUTR, V62, P645, DOI 10.1093/ajcn/62.3.645a
   Lê KA, 2011, DIABETES, V60, P2802, DOI 10.2337/db10-1263
   Lee BJ, 2012, NUTRITION, V28, P250, DOI 10.1016/j.nut.2011.06.004
   Malik VS, 2010, DIABETES CARE, V33, P2477, DOI 10.2337/dc10-1079
   Malik VS, 2010, CIRCULATION, V121, P1356, DOI 10.1161/CIRCULATIONAHA.109.876185
   McGill Anne-Thea, 2008, Metabolic Syndrome and Related Disorders, V6, P241, DOI 10.1089/met.2008.0031
   Mecca MS, 2012, DIABETOL METAB SYNDR, V4, DOI 10.1186/1758-5996-4-1
   Moreto F, 2013, INFLAMMATION, V36, P15, DOI 10.1007/s10753-012-9515-9
   Mota JF, 2008, REV NUTR, V21, P545, DOI 10.1590/S1415-52732008000500007
   Negre-Salvayre A, 2010, FREE RADICAL RES, V44, P1125, DOI 10.3109/10715762.2010.498478
   Nielsen F, 1997, CLIN CHEM, V43, P1209
   Schrauwen P, 2010, BBA-MOL CELL BIOL L, V1801, P266, DOI 10.1016/j.bbalip.2009.09.011
   Schulze MB, 2004, AM J CLIN NUTR, V80, P348, DOI 10.1093/ajcn/80.2.348
   Tchernof A, 2013, PHYSIOL REV, V93, P359, DOI 10.1152/physrev.00033.2011
   Wei YZ, 2008, WORLD J GASTROENTERO, V14, P193, DOI 10.3748/wjg.14.193
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
NR 34
TC 32
Z9 34
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2014
VL 2014
AR 505368
DI 10.1155/2014/505368
PG 7
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA AK6QF
UT WOS:000338551500001
PM 25089170
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Walvoord, EC
AF Walvoord, Emily C.
TI The Timing of Puberty: Is It Changing? Does It Matter?
SO JOURNAL OF ADOLESCENT HEALTH
LA English
DT Review
DE Puberty; Endocrine disrupting chemicals; Obesity; Secular trend;
   Menarche; breast cancer; Metabolic syndrome; Pubertal onset; Testicular
   cancer; Children; Age of puberty
ID BODY-MASS INDEX; SECONDARY SEX CHARACTERISTICS;
   HEALTH-EXAMINATION-SURVEY; OVARIAN-CANCER RISK; UNITED-STATES;
   BREAST-CANCER; TESTICULAR CANCER; MENARCHEAL AGE; SECULAR TRENDS;
   BOGALUSA HEART
AB Whether the secular trend of a decreasing age of puberty has continued over the past 50 years remains controversial. Data that had been classically used to address this issue are reviewed and large epidemiologic studies, which had not previously been included, are now considered to challenge the conclusions of prior debates of this topic. The effect and timing of excessive weight gain are discussed in detail and recent observations about the opposing effects of obesity on the pubertal timing of girls versus boys are considered. The second half of the review examines both the causes and the long-term health consequences of early puberty, touching on the possible effect of stress and endocrine-disrupting chemicals along with the risks of reproductive cancers, metabolic syndrome, and psychosocial consequences during adolescence and beyond. (C) 2010 Society for Adolescent Health and Medicine. All rights reserved.
C1 Indiana Univ Sch Med, Dept Pediat, Sect Endocrinol & Diabetol, Indianapolis, IN 46202 USA.
C3 Indiana University System; Indiana University Bloomington
RP Walvoord, EC (corresponding author), Indiana Univ Sch Med, Dept Pediat, Sect Endocrinol & Diabetol, 702 Barnhill Dr,Room 5960, Indianapolis, IN 46202 USA.
EM ewalvoor@iupui.edu
CR Ahlgren M, 2004, NEW ENGL J MED, V351, P1619, DOI 10.1056/NEJMoa040576
   Aksglaede L, 2009, PEDIATRICS, V123, pE932, DOI 10.1542/peds.2008-2491
   Anderson SE, 2003, PEDIATRICS, V111, P844, DOI 10.1542/peds.111.4.844
   Barsom SH, 2008, ANN NY ACAD SCI, V1135, P52, DOI 10.1196/annals.1429.001
   BELSKY J, 1991, CHILD DEV, V62, P647, DOI 10.2307/1131166
   BIRO FM, 1995, J PEDIATR-US, V127, P100, DOI 10.1016/S0022-3476(95)70265-2
   Biro FM, 2001, J PEDIATR-US, V138, P636, DOI 10.1067/mpd.2001.114476
   Blumenthal H, 2009, J ADOLESCENT HEALTH, V44, P401, DOI 10.1016/j.jadohealth.2008.08.023
   BROWN LM, 1986, INT J EPIDEMIOL, V15, P164, DOI 10.1093/ije/15.2.164
   Chumlea WC, 2003, PEDIATRICS, V111, P110, DOI 10.1542/peds.111.1.110
   Colón I, 2000, ENVIRON HEALTH PERSP, V108, P895, DOI 10.2307/3434999
   Conley CS, 2009, DEV PSYCHOPATHOL, V21, P593, DOI 10.1017/S0954579409000327
   DANN TC, 1993, J BIOSOC SCI, V25, P531, DOI 10.1017/S0021932000021908
   Davison KK, 2003, PEDIATRICS, V111, P815, DOI 10.1542/peds.111.4.815
   Den Hond E, 2002, ENVIRON HEALTH PERSP, V110, P771, DOI 10.1289/ehp.02110771
   Denham M, 2005, PEDIATRICS, V115, pE127, DOI 10.1542/peds.2004-1161
   Diamanti-Kandarakis E, 2009, ENDOCR REV, V30, P293, DOI 10.1210/er.2009-0002
   Dick DM, 2000, DEV PSYCHOL, V36, P180, DOI 10.1037//0012-1649.36.2.180
   Ellis BJ, 1999, J PERS SOC PSYCHOL, V77, P387, DOI 10.1037/0022-3514.77.2.387
   Ellis BJ, 2000, CHILD DEV, V71, P485, DOI 10.1111/1467-8624.00159
   Euling SY, 2008, PEDIATRICS, V121, pS172, DOI 10.1542/peds.2007-1813D
   FOSTER TA, 1977, AM J CLIN NUTR, V30, P582, DOI 10.1093/ajcn/30.4.582
   Freedman David S, 2003, BMC Pediatr, V3, P3, DOI 10.1186/1471-2431-3-3
   Freedman DS, 2002, PEDIATRICS, V110, DOI 10.1542/peds.110.4.e43
   Frontini MG, 2003, INT J OBESITY, V27, P1398, DOI 10.1038/sj.ijo.0802422
   GAIL MH, 1989, JNCI-J NATL CANCER I, V81, P1879, DOI 10.1093/jnci/81.24.1879
   Ge XJ, 2003, DEV PSYCHOL, V39, P430, DOI 10.1037/0012-1649.39.3.430
   Gladen BC, 2000, J PEDIATR-US, V136, P490, DOI 10.1016/S0022-3476(00)90012-X
   Graber JA, 2004, J AM ACAD CHILD PSY, V43, P718, DOI 10.1097/01.chi.0000120022.14101.11
   GRABER JA, 1995, CHILD DEV, V66, P346, DOI 10.1111/j.1467-8624.1995.tb00875.x
   HARLAN WR, 1980, J PEDIATR-US, V96, P1074
   HARLAN WR, 1979, J PEDIATR-US, V95, P293
   Harris MA, 2008, J ADOLESCENT HEALTH, V43, P548, DOI 10.1016/j.jadohealth.2008.07.017
   HermanGiddens ME, 1997, PEDIATRICS, V99, P505, DOI 10.1542/peds.99.4.505
   Jacobsen BK, 2007, AM J EPIDEMIOL, V166, P1431, DOI 10.1093/aje/kwm237
   Johansson TS, 2005, ENDOCRIN DEV, V8, P126, DOI 10.1159/000084098
   Kaltiala-Heino R, 2003, J ADOLESCENCE, V26, P531, DOI 10.1016/S0140-1971(03)00053-8
   Kaplowitz PB, 2001, PEDIATRICS, V108, P347, DOI 10.1542/peds.108.2.347
   Kaplowitz PB, 1999, PEDIATRICS, V104, P936, DOI 10.1542/peds.104.4.936
   Kim K, 1998, J ADOLESCENCE, V21, P231, DOI 10.1006/jado.1998.0149
   Krstevska-Konstantinova M, 2001, HUM REPROD, V16, P1020, DOI 10.1093/humrep/16.5.1020
   Lacey JV, 2009, BMC CANCER, V9, DOI 10.1186/1471-2407-9-84
   Lakshman R, 2008, DIABETOLOGIA, V51, P781, DOI 10.1007/s00125-008-0948-5
   Lam TH, 2004, ARCH SEX BEHAV, V33, P487, DOI 10.1023/B:ASEB.0000037429.79394.c6
   Lee JM, 2007, PEDIATRICS, V119, pE624, DOI 10.1542/peds.2006-2188
   Lee JM, 2010, ARCH PEDIAT ADOL MED, V164, P139, DOI 10.1001/archpediatrics.2009.258
   LEE P A, 1980, Journal of Adolescent Health Care, V1, P26, DOI 10.1016/S0197-0070(80)80005-2
   Lee PA, 2001, APMIS, V109, P81, DOI 10.1034/j.1600-0463.2001.d01-107.x
   Lynne SD, 2007, J ADOLESC HLTH, V40
   McGlynn KA, 2007, AM J EPIDEMIOL, V165, P355, DOI 10.1093/aje/kwk019
   Michaud PA, 2006, MOL CELL ENDOCRINOL, V254, P172, DOI 10.1016/j.mce.2006.04.037
   MOFFITT TE, 1992, CHILD DEV, V63, P47, DOI 10.2307/1130900
   Moller H, 1996, INT J CANCER, V66, P287, DOI 10.1002/(SICI)1097-0215(19960503)66:3<287::AID-IJC2>3.0.CO;2-V
   Moorman PG, 2009, AM J EPIDEMIOL, V170, P598, DOI 10.1093/aje/kwp176
   Must A, 2005, PEDIATRICS, V116, P620, DOI 10.1542/peds.2004-1604
   Nichols HB, 2006, AM J EPIDEMIOL, V164, P1003, DOI 10.1093/aje/kwj282
   Nicholson A. B., 1953, Child Development, V24, P3
   Obeidallah D, 2004, J AM ACAD CHILD PSY, V43, P1460, DOI 10.1097/01.chi.0000142667.52062.1e
   Ong KK, 2006, MOL CELL ENDOCRINOL, V254, P8, DOI 10.1016/j.mce.2006.04.018
   Ong KK, 2009, J CLIN ENDOCR METAB, V94, P1527, DOI 10.1210/jc.2008-2489
   Ostovich JM, 2005, ARCH SEX BEHAV, V34, P197, DOI 10.1007/s10508-005-1797-7
   Ouyang F, 2005, OCCUP ENVIRON MED, V62, P878, DOI 10.1136/oem.2005.020248
   Patton GC, 2004, PEDIATRICS, V114, pE300, DOI 10.1542/peds.2003-0626-F
   Reardon LE, 2009, CLIN PSYCHOL REV, V29, P1, DOI 10.1016/j.cpr.2008.09.005
   Reiter EO, 2001, ARCH PEDIAT ADOL MED, V155, P988, DOI 10.1001/archpedi.155.9.988
   REYNOLDS EL, 1951, AMA AM J DIS CHILD, V82, P529, DOI 10.1001/archpedi.1951.02040040549002
   REYNOLDS EL, 1948, AM J DIS CHILD, V75, P329
   Riman T, 2004, ACTA OBSTET GYN SCAN, V83, P783, DOI 10.1111/j.0001-6349.2004.00550.x
   Rosenfield RL, 2009, PEDIATRICS, V123, P84, DOI 10.1542/peds.2008-0146
   Scheidt P, 2009, ENVIRON HEALTH PERSP, V117, pA13, DOI 10.1289/ehp.12416
   Siegel JM, 1999, J ADOLESCENT HEALTH, V25, P155, DOI 10.1016/S1054-139X(98)00160-8
   Sorensen K, 2010, J CLIN ENDOCR METAB, V95, P263, DOI 10.1210/jc.2009-1478
   Stice E, 2001, DEV PSYCHOL, V37, P608, DOI 10.1037//0012-1649.37.5.608
   Sun SMS, 2002, PEDIATRICS, V110, P911, DOI 10.1542/peds.110.5.911
   Sun SS, 2005, J ADOLESCENT HEALTH, V37, P345, DOI 10.1016/j.jadohealth.2004.10.009
   Tahirovic HF, 1998, EUR J PEDIATR, V157, P978, DOI 10.1007/s004310050981
   Titus-Ernstoff L, 2001, BRIT J CANCER, V84, P714, DOI 10.1054/bjoc.2000.1596
   Tremblay L, 2005, CHILD PSYCHIAT HUM D, V36, P73, DOI 10.1007/s10578-004-3489-2
   van Jaarsveld CHM, 2007, PSYCHOSOM MED, V69, P798, DOI 10.1097/PSY.0b013e3181576106
   VANNOORD PAH, 1991, ANN HUM BIOL, V18, P57, DOI 10.1080/03014469100001402
   Vasiliu O, 2004, HUM REPROD, V19, P1506, DOI 10.1093/humrep/deh292
   Vo C, 2007, OBSTET GYN CLIN N AM, V34, P687, DOI 10.1016/j.ogc.2007.09.008
   Wang YF, 2002, PEDIATRICS, V110, P903, DOI 10.1542/peds.110.5.903
   WIERSON M, 1993, ADOLESCENCE, V28, P913
   Wolff MS, 2008, ENVIRON RES, V107, P393, DOI 10.1016/j.envres.2008.03.006
   WYSHAK G, 1982, NEW ENGL J MED, V306, P1033, DOI 10.1056/NEJM198204293061707
   Yang CY, 2005, CHEMOSPHERE, V61, P355, DOI 10.1016/j.chemosphere.2005.02.089
   Zehr JL, 2007, HORM BEHAV, V52, P427, DOI 10.1016/j.yhbeh.2007.06.005
   1994, BMJ, V308, P1393
NR 89
TC 149
Z9 170
U1 1
U2 36
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1054-139X
J9 J ADOLESCENT HEALTH
JI J. Adolesc. Health
PD NOV
PY 2010
VL 47
IS 5
BP 433
EP 439
DI 10.1016/j.jadohealth.2010.05.018
PG 7
WC Psychology, Developmental; Public, Environmental & Occupational Health;
   Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Public, Environmental & Occupational Health; Pediatrics
GA 668IY
UT WOS:000283263100004
PM 20970077
DA 2025-06-11
ER

PT J
AU Mikkelsen, ACD
   Kjærgaard, K
   Mookerjee, RP
   Vilstrup, H
   Wegener, G
   Bay-Richter, C
   Thomsen, KL
AF Mikkelsen, Anne Catrine Daugaard
   Kjaergaard, Kristoffer
   Mookerjee, Rajeshwar Prosad
   Vilstrup, Hendrik
   Wegener, Gregers
   Bay-Richter, Cecilie
   Thomsen, Karen Louise
TI Non-alcoholic Fatty Liver Disease: Also a Disease of the Brain? A
   Systematic Review of the Preclinical Evidence
SO NEUROCHEMICAL RESEARCH
LA English
DT Review
DE Non-alcoholic fatty liver disease; Neuroinflammation; Neurodegeneration;
   Neurotransmitters; Oxidative stress; Synaptic density
ID MILD COGNITIVE IMPAIRMENT; MIDDLE-AGED ADULTS; TLR4 UP-REGULATION;
   METABOLIC SYNDROME; ALZHEIMERS-DISEASE; INSULIN-RESISTANCE; GUT
   MICROBIOTA; INFLAMMATION; DEPRESSION; ASSOCIATION
AB Non-alcoholic fatty liver disease (NAFLD) currently affects 25% of the global adult population. Cognitive impairment is a recently recognised comorbidity impeding memory, attention, and concentration, affecting the patients' activities of daily living and reducing their quality of life. This systematic review provides an overview of the evidence for, and potential pathophysiological mechanisms behind brain dysfunction at a neurobiological level, in preclinical NAFLD. We performed a systematic literature search for animal models of NAFLD studying intracerebral conditions using PubMed, Embase and Scopus. We included studies that reported data on neurobiology in rodent and pig models with evidence of steatosis or steatohepatitis assessed by liver histology. 534 unique studies were identified, and 30 studies met the selection criteria, and were included. Findings of neurobiological changes were divided into five key areas: (1) neuroinflammation, (2) neurodegeneration, (3) neurotransmitter alterations, (4) oxidative stress, and (5) changes in proteins and synaptic density. Despite significant heterogeneity in the study designs, all but one study of preclinical NAFLD reported changes in one or more of the above key areas when compared to control animals. In conclusion, this systematic review supports an association between all stages of NAFLD (from simple steatosis to non-alcoholic steatohepatitis (NASH)) and neurobiological changes in preclinical models.
C1 [Mikkelsen, Anne Catrine Daugaard; Kjaergaard, Kristoffer; Mookerjee, Rajeshwar Prosad; Vilstrup, Hendrik; Thomsen, Karen Louise] Aarhus Univ Hosp, Dept Hepatol & Gastroenterol, Aarhus N, Denmark.
   [Mookerjee, Rajeshwar Prosad; Thomsen, Karen Louise] UCL, UCL Inst Liver & Digest Hlth, London, England.
   [Wegener, Gregers; Bay-Richter, Cecilie] Aarhus Univ, Dept Clin Med, Translat Neuropsychiat Unit, Aarhus C, Denmark.
C3 Aarhus University; University of London; University College London;
   Aarhus University
RP Mikkelsen, ACD (corresponding author), Aarhus Univ Hosp, Dept Hepatol & Gastroenterol, Aarhus N, Denmark.
EM ancami@clin.au.dk
RI Bay-Richter, Cecilie/AAX-2712-2020; KjÃ¦rgaard,
   Kristoffer/ADU-5541-2022; Wegener, Gregers/A-1019-2011
OI Bay-Richter, Cecilie/0000-0002-2254-4020; Daugaard Mikkelsen, Anne
   Catrine/0000-0002-7882-1816; Kjaergaard, Kristoffer/0000-0002-6440-2784;
   Thomsen, Karen Louise/0000-0002-8118-4643; Mookerjee, Rajeshwar
   Prosad/0000-0002-6275-9384; Wegener, Gregers/0000-0002-0081-0068
CR Abu Ahmad N, 2019, FASEB J, V33, P9334, DOI 10.1096/fj.201802683R
   Airaghi L, 2018, ATHEROSCLEROSIS, V268, P27, DOI 10.1016/j.atherosclerosis.2017.11.012
   Aldridge DR, 2015, J CLIN EXP HEPATOL, V5, pS7, DOI 10.1016/j.jceh.2014.06.004
   Altinoz E, 2018, BIOTECH HISTOCHEM, V93, P623, DOI 10.1080/10520295.2018.1519725
   Amin M. M., 2017, Journal of Applied Pharmaceutical Science, V7, P12
   Balzano T, 2018, J NEUROPATH EXP NEUR, V77, P837, DOI 10.1093/jnen/nly061
   Balzano T, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-21399-6
   Barnham KJ, 2004, NAT REV DRUG DISCOV, V3, P205, DOI 10.1038/nrd1330
   Becher B, 2017, NAT REV IMMUNOL, V17, P49, DOI 10.1038/nri.2016.123
   Beurel E, 2015, PHARMACOL THERAPEUT, V148, P114, DOI 10.1016/j.pharmthera.2014.11.016
   Brenes JC, 2008, PHARMACOL BIOCHEM BE, V89, P85, DOI 10.1016/j.pbb.2007.11.004
   Cai DS, 2012, AGING-US, V4, P98, DOI 10.18632/aging.100431
   Chen XX, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00434
   Chen Z, 2017, J NEUROENDOCRINOL, V29, DOI 10.1111/jne.12462
   Cheng G, 2012, INTERN MED J, V42, P484, DOI 10.1111/j.1445-5994.2012.02758.x
   Choudhary P, 2018, METAB BRAIN DIS, V33, P1563, DOI 10.1007/s11011-018-0263-x
   Cobley JN, 2018, REDOX BIOL, V15, P490, DOI 10.1016/j.redox.2018.01.008
   Colognesi M, 2020, BIOMEDICINES, V8, DOI 10.3390/biomedicines8070229
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   Day CP, 2006, CLIN MED, V6, P19, DOI 10.7861/clinmedicine.6-1-19
   de la Monte SM, 2009, MOL NEURODEGENER, V4, DOI 10.1186/1750-1326-4-54
   Delgado PL, 2000, J CLIN PSYCHIAT, V61, P7
   Doward LC, 2021, PATIENT, V14, P533, DOI 10.1007/s40271-020-00485-w
   Elliott C, 2013, DIGEST DIS SCI, V58, P2383, DOI 10.1007/s10620-013-2657-2
   Erbas O, 2015, METAB BRAIN DIS, V30, P739, DOI 10.1007/s11011-014-9630-4
   Erbas O, 2014, KAOHSIUNG J MED SCI, V30, P447, DOI 10.1016/j.kjms.2014.05.007
   Eriksen PL, 2019, LIVER INT, V39, P2094, DOI 10.1111/liv.14205
   Eriksen PL, 2019, CLIN RES HEPATOL GAS, V43, P551, DOI 10.1016/j.clinre.2019.01.001
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   Feinstein DL, 2002, NEUROCHEM INT, V41, P357, DOI 10.1016/S0197-0186(02)00049-9
   Felipo V, 2012, METAB BRAIN DIS, V27, P51, DOI 10.1007/s11011-011-9269-3
   Fortress AM, 2016, NEUROSCIENTIST, V22, P278, DOI 10.1177/1073858415574728
   Gasparova Z, 2018, GEN PHYSIOL BIOPHYS, V37, P619, DOI 10.4149/gpb_2018016
   Ghareeb DA, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/361847
   Ghareeb DA, 2011, METAB BRAIN DIS, V26, P253, DOI 10.1007/s11011-011-9261-y
   Giménez-Garzó C, 2021, J CLIN MED, V10, DOI 10.3390/jcm10132806
   Hadjihambi A, 2022, ANAL BIOCHEM, V636, DOI 10.1016/j.ab.2021.114387
   Hamon M, 2013, PROG NEURO-PSYCHOPH, V45, P54, DOI 10.1016/j.pnpbp.2013.04.009
   Hernandez F, 2013, J ALZHEIMERS DIS, V33, pS141, DOI 10.3233/JAD-2012-129025
   Higarza SG, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0223019
   Hooijmans CR, 2014, BMC MED RES METHODOL, V14, DOI 10.1186/1471-2288-14-43
   Horwath JA, 2017, JCI INSIGHT, V2, DOI 10.1172/jci.insight.90170
   Im YR, 2021, HEPATOLOGY, V74, P1884, DOI 10.1002/hep.31897
   Jacobs SAH, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081861
   Jarukamjorn K, 2016, SCIENTIFICA, V2016, DOI 10.1155/2016/5029414
   Jena PK, 2020, BIOMARK RES, V8, DOI 10.1186/s40364-020-00239-8
   Jia L, 2019, MOL BRAIN, V12, DOI 10.1186/s13041-019-0525-5
   Kendig MD, 2021, NEUROSCI BIOBEHAV R, V128, P233, DOI 10.1016/j.neubiorev.2021.05.031
   Kim DG, 2016, J NEUROINFLAMM, V13, DOI 10.1186/s12974-015-0467-5
   Kjærgaard K, 2021, J CLIN MED, V10, DOI 10.3390/jcm10040673
   Lakshmanakumar M, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-53979-5
   Lehnardt S, 2010, GLIA, V58, P253, DOI 10.1002/glia.20928
   Lu B, 2014, Handb Exp Pharmacol, V220, P223, DOI 10.1007/978-3-642-45106-5_9
   Lyn-Cook LE, 2009, J ALZHEIMERS DIS, V16, P715, DOI 10.3233/JAD-2009-0984
   Masarone M, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/9547613
   Miller AA, 2014, BRAIN BEHAV IMMUN, V42, P10, DOI 10.1016/j.bbi.2014.04.001
   Minaya DM, 2020, NUTR DIABETES, V10, DOI 10.1038/s41387-020-0119-4
   Mohammed SK, 2020, PHYSIOL BEHAV, V214, DOI 10.1016/j.physbeh.2019.112762
   Muhammad, 2020, TUMOR NECROSIS FACTO
   Murphy MP, 2010, J ALZHEIMERS DIS, V19, P311, DOI [10.3233/JAD-2009-1221, 10.3233/JAD-2010-1221]
   Newton JL, 2010, DIGEST DIS, V28, P214, DOI 10.1159/000282089
   Pan ZG, 2018, BIOCHEM BIOPH RES CO, V498, P416, DOI 10.1016/j.bbrc.2018.02.115
   Pfohl M, 2021, INT J FOOD SCI NUTR, V72, P499, DOI 10.1080/09637486.2020.1849041
   Powell EE, 2021, LANCET, V397, P2212, DOI 10.1016/S0140-6736(20)32511-3
   Reichelt AC, 2017, FRONT BEHAV NEUROSCI, V11, DOI 10.3389/fnbeh.2017.00096
   Reuter S, 2010, FREE RADICAL BIO MED, V49, P1603, DOI 10.1016/j.freeradbiomed.2010.09.006
   Rivera DS, 2018, MOL NEUROBIOL, V55, P9169, DOI 10.1007/s12035-018-0969-0
   Ross AP, 2012, PHYSIOL BEHAV, V106, P133, DOI 10.1016/j.physbeh.2012.01.008
   Santhekadur PK, 2018, J HEPATOL, V68, P230, DOI 10.1016/j.jhep.2017.10.031
   Selhub J, 2000, AM J CLIN NUTR, V71, p614S
   Selkoe DJ, 2016, EMBO MOL MED, V8, P595, DOI 10.15252/emmm.201606210
   Stols-Gonçalves D, 2019, CURR DIABETES REP, V19, DOI 10.1007/s11892-019-1151-4
   Strekalova T, 2016, J AFFECT DISORDERS, V196, P109, DOI 10.1016/j.jad.2016.02.045
   Strekalova T, 2015, BRAIN BEHAV IMMUN, V48, P42, DOI 10.1016/j.bbi.2015.02.015
   Szymonik-Lesiuk Stanislawa, 2003, J Hepatobiliary Pancreat Surg, V10, P309, DOI 10.1007/s00534-002-0824-5
   Takahashi A, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0174169
   Tengeler AC, 2020, FASEB J, V34, P9575, DOI 10.1096/fj.202000455R
   Thomsen KL, 2014, AM J PHYSIOL-GASTR L, V307, pG295, DOI 10.1152/ajpgi.00036.2014
   Tuttolomondo A, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0670-7
   Vanhanen M, 2006, NEUROLOGY, V67, P843, DOI 10.1212/01.wnl.0000234037.91185.99
   VanWagner LB, 2017, OBESITY, V25, P642, DOI 10.1002/oby.21767
   Veniaminova E, 2020, LIFE SCI, V241, DOI 10.1016/j.lfs.2019.117163
   Weinstein G, 2018, JAMA NEUROL, V75, P97, DOI 10.1001/jamaneurol.2017.3229
   Xu T, 2017, METAB BRAIN DIS, V32, P483, DOI 10.1007/s11011-016-9941-8
   Yang QQ, 2019, GLIA, V67, P1017, DOI 10.1002/glia.23571
   Younossi ZM, 2015, HEPATOLOGY, V62, p739A, DOI 10.1002/hep.28431
   Zeltser N, 2020, AM J PHYSIOL-ENDOC M, V319, pE592, DOI 10.1152/ajpendo.00120.2020
   Zhuang P, 2017, BBA-MOL BASIS DIS, V1863, P2715, DOI 10.1016/j.bbadis.2017.07.003
   Zicha J, 2006, PHYSIOL RES, V55, pS49, DOI 10.33549/physiolres.930000.55.S1.49
NR 89
TC 9
Z9 9
U1 1
U2 37
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-3190
EI 1573-6903
J9 NEUROCHEM RES
JI Neurochem. Res.
PD JUN
PY 2024
VL 49
IS 6
SI SI
BP 1468
EP 1488
DI 10.1007/s11064-022-03551-x
EA MAR 2022
PG 21
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA RM0T7
UT WOS:000762891100002
PM 35230646
DA 2025-06-11
ER

PT J
AU Suetani, S
   Mamun, A
   Williams, GM
   Najman, JM
   McGrath, JJ
   Scott, JG
AF Suetani, S.
   Mamun, A.
   Williams, G. M.
   Najman, J. M.
   McGrath, J. J.
   Scott, J. G.
TI The association between adolescent psychopathology and subsequent
   physical activity in young adulthood: a 21-year birth cohort study
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Longitudinal study; physical activity; psychopathology
ID CARDIOMETABOLIC RISK-FACTORS; MAJOR DEPRESSIVE DISORDER; MENTAL-HEALTH
   SURVEY; AGE-OF-ONSET; CARDIORESPIRATORY FITNESS; MATER-UNIVERSITY; LIFE
   EXPECTANCY; PREGNANCY MUSP; METAANALYSIS; EXERCISE
AB Background. The beneficial effects of physical activity (PA) for both physical and mental wellbeing are well established. Given that adolescence presents a critical developmental period during which life-long patterns of PA become established, the exploration of the longitudinal impact of adolescent psychopathology on adult PA status is of interest.
   Methods. We analysed prospective data from 3663 young adults who participated in the Mater-University of Queensland Study of Pregnancy. Psychopathology was measured using the Youth Self-Report (YSR) at age 14. Participants' engagement in three types of PA (vigorous exercise, moderate exercise and walking) at age 21 were dichotomised into either 'none' or 'any'. For our main analysis, we examined the association between the YSR score and subsequent PA engagement using logistic regression. We also conducted sensitivity analyses of longitudinal associations between the YSR internalising and externalising symptoms score at age 14 and PA engagement at age 21.
   Results. We found no longitudinal association between the total YSR score at age 14 and PA engagement at age 21. In addition, there was no longitudinal association between the YSR internalising or externalising symptoms and PA engagement.
   Conclusion. Our findings suggest that there is no longitudinal association between adolescent psychopathology and PA in young adulthood.
C1 [Suetani, S.; McGrath, J. J.; Scott, J. G.] Pk Ctr Mental Hlth, Queensland Ctr Mental Hlth Res, Wacol, Qld 4076, Australia.
   [Suetani, S.; McGrath, J. J.] Univ Queensland, Queensland Brain Inst, St Lucia, Qld, Australia.
   [Suetani, S.] Metro South Addict & Mental Hlth Serv, Brisbane, Qld, Australia.
   [Mamun, A.] Univ Queensland, Inst Social Sci Res, Indooroopilly, Qld, Australia.
   [Williams, G. M.; Najman, J. M.] Univ Queensland, Sch Populat Hlth, Herston, Qld, Australia.
   [Najman, J. M.] Univ Queensland, Sch Social Sci, St Lucia, Qld, Australia.
   [McGrath, J. J.] Aarhus Univ, Natl Ctr Register Based Res, Aarhus C, Denmark.
   [Scott, J. G.] Univ Queensland, Ctr Clin Res, Herston, Qld, Australia.
   [Scott, J. G.] Royal Brisbane & Womens Hosp, Metro North Mental Hlth, Herston, Qld, Australia.
C3 Queensland Centre for Mental Health Research; University of Queensland;
   University of Queensland; University of Queensland; University of
   Queensland; Aarhus University; University of Queensland; Royal Brisbane
   & Women's Hospital
RP Suetani, S (corresponding author), Pk Ctr Mental Hlth, Queensland Ctr Mental Hlth Res, Wacol, Qld 4076, Australia.
EM shuichi.suetani@health.qld.gov.au
RI Williams, Gail/S-8833-2019; Mamun, Abdullah/HHM-9898-2022; Najman,
   Jackob/B-1527-2008; McGrath, John/G-5493-2010; Scott, James/D-5900-2012;
   Mamun, Abdullah/A-4673-2011
OI Najman, Jackob/0000-0001-7079-2080; McGrath, John/0000-0002-4792-6068;
   Scott, James/0000-0002-0744-0688; Williams, Gail/0000-0002-4822-5263;
   Suetani, Shuichi/0000-0002-2487-5691; Mamun,
   Abdullah/0000-0002-1535-8086
FU National Health and Medical Research Council (NHMRC) [1009460]; National
   Health and Medical Research Council Practitioner Fellowship [1105807];
   National Health and Medical Research Council [APP1056929]
FX The MUSP is funded by the National Health and Medical Research Council
   (NHMRC grant no. 1009460). J. G Scott is supported by a National Health
   and Medical Research Council Practitioner Fellowship Grant no. 1105807.
   J. J. McGrath received John Cade Fellowship APP1056929 from the National
   Health and Medical Research Council.
CR Achenbach T.M., 1997, Manual for the Young Adult Self-Report and Young Adult Behavior Checklist
   Achenbach T.M., 1987, MANUAL YOUTH SELF RE
   Arem H, 2015, JAMA INTERN MED, V175, P959, DOI 10.1001/jamainternmed.2015.0533
   Birkeland MS, 2009, PSYCHOL SPORT EXERC, V10, P25, DOI 10.1016/j.psychsport.2008.01.005
   CASPERSEN CJ, 1985, PUBLIC HEALTH REP, V100, P126
   Cureau FV, 2017, INT J OBESITY, V41, P551, DOI 10.1038/ijo.2016.210
   De Moor MHM, 2006, PREV MED, V42, P273, DOI 10.1016/j.ypmed.2005.12.002
   Due P, 2011, SCAND J PUBLIC HEALT, V39, P62, DOI 10.1177/1403494810395989
   Ekelund U, 2012, JAMA-J AM MED ASSOC, V307, P704, DOI 10.1001/jama.2012.156
   Firth J, 2015, PSYCHOL MED, V45, P1343, DOI 10.1017/S0033291714003110
   Firth J, 2018, EARLY INTERV PSYCHIA, V12, P578, DOI 10.1111/eip.12365
   Galletly CA, 2012, AUST NZ J PSYCHIAT, V46, P753, DOI 10.1177/0004867412453089
   Hayatbakhsh MR, 2008, SOC PSYCH PSYCH EPID, V43, P356, DOI 10.1007/s00127-008-0325-1
   Hjorthoj C, 2017, LANCET PSYCHIAT, V4, P295, DOI 10.1016/S2215-0366(17)30078-0
   Kessler RC, 2007, WORLD PSYCHIATRY, V6, P168
   Kessler RC, 2007, CURR OPIN PSYCHIATR, V20, P359, DOI 10.1097/YCO.0b013e32816ebc8c
   Lee IM, 2012, LANCET, V380, P219, DOI 10.1016/S0140-6736(12)61031-9
   Lee PH, 2011, INT J BEHAV NUTR PHY, V8, DOI 10.1186/1479-5868-8-115
   Mamun AA, 2009, OBESITY, V17, P761, DOI 10.1038/oby.2008.594
   Najman JM, 2015, INT J EPIDEMIOL, V44, P78, DOI 10.1093/ije/dyu234
   Najman JM, 2005, INT J EPIDEMIOL, V34, P992, DOI 10.1093/ije/dyi119
   O'Donovan G, 2017, JAMA INTERN MED, V177, P335, DOI 10.1001/jamainternmed.2016.8014
   Pereira SMP, 2014, AM J EPIDEMIOL, V180, P1098, DOI 10.1093/aje/kwu254
   Poulsen PH, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-015-2658-5
   Rosenbaum S, 2016, AUSTRALAS PSYCHIATRY, V24, P49, DOI 10.1177/1039856215590252
   Sabiston CM, 2013, PREV MED, V56, P95, DOI 10.1016/j.ypmed.2012.11.013
   Sagatun A, 2007, BMC PUBLIC HEALTH, V7, DOI 10.1186/1471-2458-7-155
   Schuch F, 2017, J AFFECT DISORDERS, V210, P139, DOI 10.1016/j.jad.2016.10.050
   Schuch FB, 2016, PREV MED, V93, P159, DOI 10.1016/j.ypmed.2016.10.011
   Scott J, 2009, AM J PSYCHIAT, V166, P567, DOI 10.1176/appi.ajp.2008.08081182
   Scott KM, 2016, JAMA PSYCHIAT, V73, P150, DOI 10.1001/jamapsychiatry.2015.2688
   Sormunen E, 2017, NPJ SCHIZOPHR, V3, DOI 10.1038/s41537-016-0007-z
   Stubbs B, 2017, PSYCHIAT RES, V249, P102, DOI 10.1016/j.psychres.2016.12.020
   Stubbs B, 2016, SCHIZOPHR RES, V176, P431, DOI 10.1016/j.schres.2016.05.017
   Suetani S, 2016, ACTA PSYCHIAT SCAND, V134, P129, DOI 10.1111/acps.12594
   Suetani S, 2017, SOC PSYCH PSYCH EPID, V52, P795, DOI 10.1007/s00127-016-1307-3
   ten Have M, 2011, J PSYCHOSOM RES, V71, P342, DOI 10.1016/j.jpsychores.2011.04.001
   Toseeb U, 2014, JAMA PEDIATR, V168, P1093, DOI 10.1001/jamapediatrics.2014.1794
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vancampfort D, 2017, SPORTS MED, V47, P343, DOI 10.1007/s40279-016-0574-1
   Vancampfort D, 2016, WORLD PSYCHIATRY, V15, P166, DOI 10.1002/wps.20309
   Vancampfort D, 2011, PSYCHIAT RES, V187, P62, DOI 10.1016/j.psychres.2010.11.027
   Walker ER, 2015, JAMA PSYCHIAT, V72, P334, DOI 10.1001/jamapsychiatry.2014.2502
   Welham J, 2009, SCHIZOPHRENIA BULL, V35, P603, DOI 10.1093/schbul/sbn084
   Yung AR, 2017, EXPERT REV NEUROTHER, V17, P213, DOI 10.1080/14737175.2017.1275571
NR 45
TC 7
Z9 7
U1 0
U2 10
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD JAN
PY 2018
VL 48
IS 2
BP 269
EP 278
DI 10.1017/S0033291717001660
PG 10
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA FR0GV
UT WOS:000418740300009
PM 28625171
DA 2025-06-11
ER

PT J
AU Maneschi, E
   Cellai, I
   Aversa, A
   Mello, T
   Filippi, S
   Comeglio, P
   Bani, D
   Guasti, D
   Sarchielli, E
   Salvatore, G
   Morelli, A
   Mazzanti, B
   Corcetto, F
   Corno, C
   Francomano, D
   Galli, A
   Vannelli, GB
   Lenzi, A
   Mannucci, E
   Maggi, M
   Vignozzi, L
AF Maneschi, Elena
   Cellai, Ilaria
   Aversa, Antonio
   Mello, Tommaso
   Filippi, Sandra
   Comeglio, Paolo
   Bani, Daniele
   Guasti, Daniele
   Sarchielli, Erica
   Salvatore, Giulia
   Morelli, Annamaria
   Mazzanti, Benedetta
   Corcetto, Francesca
   Corno, Chiara
   Francomano, Davide
   Galli, Andrea
   Vannelli, Gabriella Barbara
   Lenzi, Andrea
   Mannucci, Edoardo
   Maggi, Mario
   Vignozzi, Linda
TI Tadalafil reduces visceral adipose tissue accumulation by promoting
   preadipocytes differentiation towards a metabolically healthy phenotype:
   Studies in rabbits
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article
DE Metabolic syndrome; Tadalafil; PDE5; Insulin-resistance
ID INDUCED ERECTILE DYSFUNCTION; BROWN-FAT; SKELETAL-MUSCLE; MITOCHONDRIAL
   DYSFUNCTION; PROSTATE ALTERATIONS; THERMOGENIC PROGRAM; BLADDER
   ALTERATIONS; OXIDATIVE STRESS; GENE-EXPRESSION; PDE5 INHIBITORS
AB Development of metabolically healthy adipocytes within dysfunctional adipose tissue may represent an attractive way to counteract metabolic syndrome (MetS). In an experimental animal model of high fat diet (HFD)-induced MetS, in vivo, long- and short-term tadalafil treatments were able to reduce visceral adipose tissue (VAT) accumulation and hypertriglyceridemia, and to induce the expression in VAT of the brown fat-specific marker, uncoupling protein 1 (UCP1). VAT preadipocytes (PAD), isolated from the tadalafil-treated HFD rabbits, showed: i) a multilocular morphology; ii) an increased expression of brown fat-specific genes (such as UCP1 and CIDEA); iii) improved mitochondrial structure and dynamic and reduced superoxide production; iv) improved insulin sensitivity. Similar effects were obtained after in vitro tadalafil treatment in HFD rPAD. In conclusion, tadalafil counteracted HFD-associated VAT alterations, by restoring insulin-sensitivity and prompting preadipocytes differentiation towards a metabolically healthy phenotype. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Maneschi, Elena; Cellai, Ilaria; Comeglio, Paolo; Salvatore, Giulia; Corcetto, Francesca; Corno, Chiara; Maggi, Mario; Vignozzi, Linda] Univ Florence, Dept Expt & Clin Biomed Sci, Sexual Med & Androl Unit, Viale Morgagni 50, I-50134 Florence, Italy.
   [Aversa, Antonio; Francomano, Davide; Lenzi, Andrea] Univ Roma La Sapienza, Food Sci & Endocrinol Sect, Med Pathophysiol, Dept Expt Med, Viale Regina Elena 324, I-00161 Rome, Italy.
   [Mello, Tommaso; Galli, Andrea] Univ Florence, Dept Expt & Clin Biomed Sci, Gastroenterol Unit, I-50134 Florence, Italy.
   [Filippi, Sandra] Univ Florence, Dept Neurosci Drug Res & Child Care, Interdept Lab Funct & Cellular Pharmacol Reprod, Pieraccini 6, I-50139 Florence, Italy.
   [Bani, Daniele; Guasti, Daniele; Sarchielli, Erica; Morelli, Annamaria; Mazzanti, Benedetta; Vannelli, Gabriella Barbara] Univ Florence, Dept Expt & Clin Med, Largo Brambilla 3, I-50134 Florence, Italy.
   [Mannucci, Edoardo] Careggi Hosp, Dept Crit Care, Diabet Sect Geriatr Unit, Largo Brambilla 3, I-50134 Florence, Italy.
C3 University of Florence; Sapienza University Rome; University of
   Florence; University of Florence; University of Florence; University of
   Florence; Azienda Ospedaliero Universitaria Careggi
RP Vignozzi, L (corresponding author), Univ Florence, Gynaecol Endocrinol Unit, Dept Expt & Clin Biomed Sci, Viale Pieraccini 6, I-50139 Florence, Italy.
EM linda.vignozzi@unifi.it
RI Aversa, Antonio/O-3151-2019; Morelli, Annamaria/AAS-4244-2020; Maggi,
   Mario/AAB-8284-2019; Galli, Andrea/AAC-1623-2019; Bani,
   Daniele/AAC-7234-2021; Mello, Tommaso/I-4715-2012; Mannucci,
   Edoardo/K-6749-2016
OI MAGGI, Mario/0000-0003-3267-4221; Vignozzi, Linda/0000-0003-0907-0630;
   DANIELE, GUASTI/0000-0002-2856-6829; Mello, Tommaso/0000-0002-6192-6902;
   Salvatore, Giulia/0000-0003-3573-9254; CORNO,
   CHIARA/0000-0002-0012-6522; Mannucci, Edoardo/0000-0001-9759-9408;
   Galli, Andrea/0000-0001-5416-6290
CR Anderson EJ, 2009, J CLIN INVEST, V119, P573, DOI 10.1172/JCI37048
   Armani A, 2011, TRENDS ENDOCRIN MET, V22, P404, DOI 10.1016/j.tem.2011.05.004
   Aversa A, 2011, J SEX MED, V8, P696, DOI 10.1111/j.1743-6109.2010.02152.x
   Ayala JE, 2007, DIABETES, V56, P1025, DOI 10.2337/db06-0883
   Bach D, 2003, J BIOL CHEM, V278, P17190, DOI 10.1074/jbc.M212754200
   Baglioni S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036569
   Baglioni S, 2009, FASEB J, V23, P3494, DOI 10.1096/fj.08-126946
   Berry R, 2013, NAT CELL BIOL, V15, P302, DOI 10.1038/ncb2696
   Bonnard C, 2008, J CLIN INVEST, V118, P789, DOI 10.1172/JCI32601
   Bordicchia M, 2012, J CLIN INVEST, V122, P1022, DOI 10.1172/JCI59701
   Boudina S, 2012, ENDOCRINOLOGY, V153, P2677, DOI 10.1210/en.2011-2147
   Cederberg A, 2001, CELL, V106, P563, DOI 10.1016/S0092-8674(01)00474-3
   Chechi K, 2014, OBES REV, V15, P92, DOI 10.1111/obr.12116
   Comeglio P, 2014, PROSTATE, V74, P10, DOI 10.1002/pros.22723
   Cummings DE, 1996, NATURE, V382, P622, DOI 10.1038/382622a0
   Cusi K, 2010, CURR DIABETES REP, V10, P306, DOI 10.1007/s11892-010-0122-6
   De Arcangelis V, 2016, J CELL PHYSIOL, V231, P224, DOI 10.1002/jcp.25075
   DeFronzo RA, 2004, INT J CLIN PRACT, V58, P9, DOI 10.1111/j.1368-504X.2004.00389.x
   DELEAN A, 1978, AM J PHYSIOL, V235, pE97, DOI 10.1152/ajpendo.1978.235.2.E97
   Detmer SA, 2007, NAT REV MOL CELL BIO, V8, P870, DOI 10.1038/nrm2275
   Filippi S, 2009, J SEX MED, V6, P3274, DOI 10.1111/j.1743-6109.2009.01467.x
   Frezza C, 2006, CELL, V126, P177, DOI 10.1016/j.cell.2006.06.025
   Gnanasegaran N, 2014, INT J MED SCI, V11, P391, DOI 10.7150/ijms.7697
   Haas B, 2009, SCI SIGNAL, V2, DOI 10.1126/scisignal.2000511
   Harms M, 2013, NAT MED, V19, P1252, DOI 10.1038/nm.3361
   Hellstrom L, 1996, DIABETOLOGIA, V39, P921
   Hoffmann LS, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8235
   Ishibashi J, 2010, SCIENCE, V328, P1113, DOI 10.1126/science.1190816
   Jocken J.W., 2015, INT J OBES LOND
   Joe AWB, 2009, STEM CELLS, V27, P2563, DOI 10.1002/stem.190
   Kelley DE, 2002, DIABETES, V51, P2944, DOI 10.2337/diabetes.51.10.2944
   Kiefer FW, 2012, NAT MED, V18, P918, DOI 10.1038/nm.2757
   Kim DS, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0083363
   Koka S, 2014, AM J PHYSIOL-HEART C, V306, pH1558, DOI 10.1152/ajpheart.00865.2013
   Kozak LP, 2010, CELL METAB, V11, P263, DOI 10.1016/j.cmet.2010.03.009
   Lee KH, 2014, CLIN EXP PHARMACOL P, V41, P763, DOI 10.1111/1440-1681.12290
   Liesa M, 2013, CELL METAB, V17, P491, DOI 10.1016/j.cmet.2013.03.002
   Maneschi E, 2013, J ENDOCRINOL, V218, P215, DOI 10.1530/JOE-13-0109
   Maneschi E, 2012, J ENDOCRINOL, V215, P347, DOI 10.1530/JOE-12-0333
   Marchiani S, 2015, MOL CELL ENDOCRINOL, V401, P12, DOI 10.1016/j.mce.2014.11.005
   Martin SD, 2014, MOL METAB, V3, P408, DOI 10.1016/j.molmet.2014.02.001
   Mitschke MM, 2013, FASEB J, V27, P1621, DOI 10.1096/fj.12-221580
   Morelli A, 2005, INT J ANDROL, V28, P23, DOI 10.1111/j.1365-2605.2005.00550.x
   Morelli A, 2014, MOL CELL ENDOCRINOL, V382, P107, DOI 10.1016/j.mce.2013.09.017
   Morelli A, 2013, PROSTATE, V73, P428, DOI 10.1002/pros.22584
   Morelli A, 2012, J STEROID BIOCHEM, V132, P80, DOI 10.1016/j.jsbmb.2012.02.007
   Morelli A, 2011, BBA-MOL BASIS DIS, V1812, P859, DOI 10.1016/j.bbadis.2010.10.013
   Newmeyer DD, 2003, CELL, V112, P481, DOI 10.1016/S0092-8674(03)00116-8
   Nincheri P, 2009, CELL MOL LIFE SCI, V66, P1741, DOI 10.1007/s00018-009-9181-8
   Nisoli E, 2003, SCIENCE, V299, P896, DOI 10.1126/science.1079368
   Petrovic N, 2010, J BIOL CHEM, V285, P7153, DOI 10.1074/jbc.M109.053942
   Porst H, 2013, J SEX MED, V10, P130, DOI 10.1111/jsm.12023
   Rodeheffer MS, 2008, CELL, V135, P240, DOI 10.1016/j.cell.2008.09.036
   Rousset S, 2004, DIABETES, V53, pS130, DOI 10.2337/diabetes.53.2007.S130
   Schindelin J, 2012, NAT METHODS, V9, P676, DOI [10.1038/NMETH.2019, 10.1038/nmeth.2019]
   Schulz TJ, 2013, NATURE, V495, P379, DOI 10.1038/nature11943
   Seale P, 2011, J CLIN INVEST, V121, P96, DOI 10.1172/JCI44271
   STUDENT AK, 1980, J BIOL CHEM, V255, P4745
   Tchernof A, 2013, PHYSIOL REV, V93, P359, DOI 10.1152/physrev.00033.2011
   Toledo FGS, 2006, J CLIN ENDOCR METAB, V91, P3224, DOI 10.1210/jc.2006-0002
   Vignozzi L, 2014, J SEX MED, V11, P2890, DOI 10.1111/jsm.12695
   Vignozzi L, 2014, J SEX MED, V11, P1694, DOI 10.1111/jsm.12572
   Vignozzi L, 2014, J SEX MED, V11, P1159, DOI 10.1111/jsm.12478
   Vignozzi L, 2014, MOL CELL ENDOCRINOL, V384, P143, DOI 10.1016/j.mce.2014.01.014
   Vignozzi L, 2013, PROSTATE, V73, P1391, DOI 10.1002/pros.22686
   Vignozzi L, 2012, J ENDOCRINOL, V212, P71, DOI 10.1530/JOE-11-0289
   Vignozzi L, 2011, J SEX MED, V8, P57, DOI 10.1111/j.1743-6109.2010.02073.x
   Waldén TB, 2012, AM J PHYSIOL-ENDOC M, V302, pE19, DOI 10.1152/ajpendo.00249.2011
   Wu J, 2012, CELL, V150, P366, DOI 10.1016/j.cell.2012.05.016
   Yu TZ, 2006, P NATL ACAD SCI USA, V103, P2653, DOI 10.1073/pnas.0511154103
   Zhang XD, 2010, BIOCHEM BIOPH RES CO, V396, P1054, DOI 10.1016/j.bbrc.2010.05.064
   Zuk PA, 2002, MOL BIOL CELL, V13, P4279, DOI 10.1091/mbc.E02-02-0105
   Zuk PA, 2001, TISSUE ENG, V7, P211, DOI 10.1089/107632701300062859
NR 73
TC 22
Z9 23
U1 0
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD MAR 15
PY 2016
VL 424
IS C
BP 50
EP 70
DI 10.1016/j.mce.2016.01.015
PG 21
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA DH3GJ
UT WOS:000372675200006
PM 26805634
DA 2025-06-11
ER

PT J
AU Marotta, F
   Kumari, A
   Catanzaro, R
   Solimene, U
   Jain, S
   Minelli, E
   Harada, M
AF Marotta, Francesco
   Kumari, Archana
   Catanzaro, Roberto
   Solimene, Umberto
   Jain, Shalini
   Minelli, Emilio
   Harada, Masatoshi
TI A Phytochemical Approach to Experimental Metabolic Syndrome-Associated
   Renal Damage and Oxidative Stress
SO REJUVENATION RESEARCH
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; KIDNEY-DISEASE; FRUCTOSE; HYPERTENSION;
   NOTOGINSENG; MORTALITY; EXTRACTS
AB The aim of this study was to evaluate the effect of DTS-phytocompound on oxidant-antioxidant balance and protein damage in the kidneys of rats administered high doses of fructose. Adult male Wistar rats were divided into four groups. Group A received a control diet, whereas groups B and C were fed a high-fructose diet (60 g/100 g), the latter with additional DTS (50 mg/kg per day) for 60 days. Lipo-and nitro-peroxidation together with alpha-smooth muscle actin (alpha-SMA) expression in the glomerular and interstitial tissue of the kidneys were measured after 60 days. Fructose-fed rats showed significantly higher lipoperoxidation, 2,4-dinitrophenol and 3-nitrotyrosine protein adducts, and upregulation of alpha-SMA in the kidney. DTS significantly decreased such redox unbalance in renal tissue, while partially downregulating alpha-SMA (p < 0.01). These data suggest the potential clinical benefit of DTS in protecting the kidneys from metabolic syndrome-associated changes; gender-related analysis is under way.
C1 [Marotta, Francesco] ReGenera Res Grp Aging Intervent, I-20154 Milan, Italy.
   [Kumari, Archana] Univ Quebec, Inst Natl Rech Sci, Ctr Eau Terre & Environm, Quebec City, PQ, Canada.
   [Catanzaro, Roberto] Univ Catania, Dept Internal Med, Gastroenterol Unit, Catania, Italy.
   [Solimene, Umberto; Minelli, Emilio] Univ Milan, WHO Ctr Biotechnol & Tradit Med, Milan, Italy.
   [Jain, Shalini] NIDDK, NIH, Bethesda, MD USA.
   [Harada, Masatoshi] MCH Hosp, Saitama, Japan.
C3 University of Quebec; Institut national de la recherche scientifique
   (INRS); University of Catania; University of Milan; National Institutes
   of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive &
   Kidney Diseases (NIDDK)
RP Marotta, F (corresponding author), ReGenera Res Grp Aging Intervent, Piazza Firenze 12, I-20154 Milan, Italy.
EM fmarchimede@libero.it
RI Marotta, Francesco/ABI-1960-2020; CATANZARO, Roberto/ABE-8085-2020
OI CATANZARO, Roberto/0000-0003-4852-9125; Marotta,
   Francesco/0000-0002-6016-1864
CR Abdulla MH, 2011, INT J NEPHROL, V2011, DOI 10.4061/2011/934659
   Bray GA, 2007, AM J CLIN NUTR, V86, P895, DOI 10.1093/ajcn/86.4.895
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Cirillo P, 2009, J AM SOC NEPHROL, V20, P545, DOI 10.1681/ASN.2008060576
   Hao Z, 2007, INTERNAL MED, V46, P341, DOI 10.2169/internalmedicine.46.6056
   Jin X, 2008, ACTA MED OKAYAMA, V62, P319
   Johnson RJ, 2007, AM J CLIN NUTR, V86, P899
   Karamouzis I, 2011, HORM METAB RES, V43, P607, DOI 10.1055/s-0031-1284355
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Marotta F, 2006, ANN NY ACAD SCI, V1067, P408, DOI 10.1196/annals.1354.058
   Marotta F, 2010, J BIOL REG HOMEOS AG, V24, P41
   Marotta F, 2008, REJUV RES, V11, P513, DOI 10.1089/rej.2008.0681
   Miller A, 2008, CURR OPIN GASTROEN, V24, P204, DOI 10.1097/MOG.0b013e3282f3f4c4
   Nakagawa T, 2006, AM J PHYSIOL-RENAL, V290, pF625, DOI 10.1152/ajprenal.00140.2005
   Rayssiguier Y, 2006, MAGNESIUM RES, V19, P237
   Sanchez-Lozada LG, 2007, AM J PHYSIOL-RENAL, V292, pF423, DOI 10.1152/ajprenal.00124.2006
   Xia W, 2011, PHYTOMEDICINE, V18, P516, DOI 10.1016/j.phymed.2010.09.007
   Xu ZS, 2010, J AGR FOOD CHEM, V58, P7289, DOI 10.1021/jf100304t
   Yoshikawa M, 2001, CHEM PHARM BULL, V49, P1452, DOI 10.1248/cpb.49.1452
   Zhang Yi, 2005, Hepatobiliary Pancreat Dis Int, V4, P207
NR 21
TC 1
Z9 1
U1 0
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1549-1684
EI 1557-8577
J9 REJUV RES
JI Rejuv. Res.
PD APR
PY 2012
VL 15
IS 2
BP 153
EP 156
DI 10.1089/rej.2011.1266
PG 4
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 933SS
UT WOS:000303383600010
PM 22533421
DA 2025-06-11
ER

PT J
AU Szczepanska, E
   Janota, B
   Wlazlo, M
   Gacal, M
AF Szczepanska, Elzbieta
   Janota, Barbara
   Wlazlo, Marika
   Gacal, Magdalena
TI Can Daily Dietary Choices Have a Cardioprotective Effect? Food Compounds
   in the Prevention and Treatment of Cardiometabolic Diseases
SO METABOLITES
LA English
DT Review
DE metabolic syndrome; cardiovascular disease; diet; nutrients; food
ID POLYUNSATURATED FATTY-ACIDS; CARDIOVASCULAR-DISEASE; BLOOD-PRESSURE;
   FIBER INTAKE; VITAMIN-C; HEALTH; SUPPLEMENTATION; STRESS; IMPACT
AB Cardiovascular diseases accompanying metabolic syndrome comprise one of the leading causes of death worldwide. The medical community undertakes attempts to improve treatment options and minimize cardiovascular diseases' numerous consequences and exacerbations. In parallel with pharmacotherapies provided by physicians, nutritionists are developing strategies for diet therapy and prevention based on lifestyle changes, with high success rates. Consumption of specified food compounds included in various products with proven protective properties can be helpful in this regard. Due to the wide possibilities of diet in metabolic health promotion, it seems necessary to systematize information about the metabolically protective and cardioprotective properties of fiber, probiotic bacteria, plant sterols, folic acid, vitamins B12, C, and E, PUFAs, lycopene, polyphenols, arginine, CoQ10, and allicin. The aim of this review was to present the food compounds with potential use in cardiometabolic prevention and diet therapy based on the latest available literature.
C1 [Szczepanska, Elzbieta] Med Univ Silesia, Fac Publ Hlth Bytom, Dept Human Nutr, Dept Dietet, Jordana 19 St, PL-41808 Zabrze, Poland.
   [Janota, Barbara] Med Univ Silesia, Fac Publ Hlth Bytom, Doctoral Sch, Dept Basic Med Sci, Piekarska 18 St, PL-41902 Bytom, Poland.
   [Wlazlo, Marika; Gacal, Magdalena] Med Univ Silesia, Fac Publ Hlth Bytom, Doctoral Sch, Piekarska 18 St, PL-41902 Bytom, Poland.
C3 Medical University of Silesia; Medical University of Silesia; Medical
   University of Silesia
RP Janota, B (corresponding author), Med Univ Silesia, Fac Publ Hlth Bytom, Doctoral Sch, Dept Basic Med Sci, Piekarska 18 St, PL-41902 Bytom, Poland.
EM d201083@365.sum.edu.pl
OI Wlazlo, Marika/0000-0003-0476-3585; Szczepanska,
   Elzbieta/0000-0001-9683-8999
CR An P, 2022, J AM COLL CARDIOL, V80, P2269, DOI 10.1016/j.jacc.2022.09.048
   [Anonymous], 2023, Mean Salt Intake in Adults Aged 25 Years and Older in the Americas, 1990-2019
   Ashcroft SP, 2024, CELL METAB, V36, P278, DOI 10.1016/j.cmet.2023.12.008
   Ashok T, 2021, CUREUS J MED SCIENCE, V13, DOI 10.7759/cureus.18521
   Barkas F, 2020, NUTRIENTS, V12, DOI 10.3390/nu12082436
   Barrett EM, 2020, PUBLIC HEALTH NUTR, V23, P1404, DOI 10.1017/S1368980019004233
   Belardo D, 2022, AM J PREVENT CARDIOL, V10, DOI 10.1016/j.ajpc.2022.100323
   Bomhof-Roordink H, 2015, J PSYCHOSOM RES, V78, P332, DOI 10.1016/j.jpsychores.2015.02.009
   Boonthongkaew C, 2021, CHINESE J PHYSIOL, V64, P16, DOI 10.4103/cjp.cjp_95_20
   Butnariu M., 2019, International Journal of Nutrition, V3, P7, DOI DOI 10.14302/ISSN.2379-7835.IJN-19-2615
   Castro-Barquero S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12102983
   Catapano AL, 2016, KARDIOL POL, V74, P1234, DOI 10.5603/KP.2016.0157
   Cedó L, 2019, CURR MED CHEM, V26, P6704, DOI 10.2174/0929867326666190822154701
   Chen WJ, 2023, NUTRIENTS, V15, DOI 10.3390/nu15234898
   Chen X, 2019, CHINESE MED J-PEKING, V132, P1843, DOI 10.1097/CM9.0000000000000330
   Chow SL, 2023, CIRCULATION, V147, pE4, DOI 10.1161/CIR.0000000000001110
   Chrzastek Z, 2023, NUTRITION, V106, DOI 10.1016/j.nut.2022.111892
   Cicero AFG, 2021, CURR ATHEROSCLER REP, V23, DOI 10.1007/s11883-021-00955-y
   Colussi G, 2017, NUTR METAB CARDIOVAS, V27, P191, DOI 10.1016/j.numecd.2016.07.011
   Costanza AC, 2015, INT J CARDIOL, V179, P348, DOI 10.1016/j.ijcard.2014.11.034
   Dahiya D, 2023, FERMENTATION-BASEL, V9, DOI 10.3390/fermentation9010001
   Dai SM, 2024, NUTRIENTS, V16, DOI 10.3390/nu16071017
   Di Pietro P, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1327394
   Dludla PV, 2020, ENDOCRIN DIAB METAB, V3, DOI 10.1002/edm2.118
   Dryer-Beers ER, 2024, J NUTR, V154, P2470, DOI 10.1016/j.tjnut.2024.05.005
   Dyrcz D., 2019, Forum Med. Rodz, V13, P36
   Feng SM, 2020, COMPR REV FOOD SCI F, V19, P1243, DOI 10.1111/1541-4337.12560
   Fuentes E, 2021, CURR DRUG TARGETS, V22, P1716, DOI 10.2174/1389450122999210128180456
   Garg A, 2022, LIFE-BASEL, V12, DOI 10.3390/life12020310
   Gawrys J, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/1015908
   Gonçalves C, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113447
   Granato D, 2020, ANNU REV FOOD SCI T, V11, P93, DOI 10.1146/annurev-food-032519-051708
   Guarnizo-Poma M, 2018, DIABETES METAB SYND, V12, P943, DOI 10.1016/j.dsx.2018.05.022
   Guembe MJ, 2020, CARDIOVASC DIABETOL, V19, DOI 10.1186/s12933-020-01166-6
   Hashim KN, 2021, MOLECULES, V26, DOI 10.3390/molecules26040808
   Hosseini A, 2015, J ENDOCRINOL INVEST, V38, P1147, DOI 10.1007/s40618-015-0313-8
   Hsu CN, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222111872
   Idrus RBH, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17103613
   Imaizumi VM, 2023, CRIT REV FOOD SCI, V63, P6797, DOI 10.1080/10408398.2022.2043821
   Kaur R, 2020, LIPIDS, V55, P569, DOI 10.1002/lipd.12262
   Khandouzi N, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-01362-z
   Khosravi M, 2019, BIOL CHEM, V400, P711, DOI 10.1515/hsz-2018-0397
   Koodziejczyk P., 2018, ywno Nauka Technol. Jako, V3, P13, DOI [10.15193/ZNTJ/2018/116/242, DOI 10.15193/ZNTJ/2018/116/242]
   Küçük N, 2023, J HEALTH POPUL NUTR, V42, DOI 10.1186/s41043-023-00382-6
   Lange K.W., 2019, J. Food Bioact, V7, P1, DOI [10.31665/JFB.2019.7192, DOI 10.31665/JFB.2019.7192]
   Le Goff D, 2023, INT J BEHAV NUTR PHY, V20, DOI 10.1186/s12966-023-01463-9
   Leskinen T, 2018, PREV MED, V112, P31, DOI 10.1016/j.ypmed.2018.03.020
   Lewis ME, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18041821
   Li X, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.704145
   Liu ZH, 2022, J CLIN ENDOCR METAB, DOI 10.1210/clinem/dgac585
   Luc K, 2019, J PHYSIOL PHARMACOL, V70, P809, DOI 10.26402/jpp.2019.6.01
   Ma LS, 2018, AGING DIS, V9, P938, DOI 10.14336/AD.2017.1207
   Malik VS, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081840
   Meadley B, 2022, PREHOSP EMERG CARE, V26, P380, DOI 10.1080/10903127.2021.1907492
   Merenkova SP, 2020, HUM SPORT MED, V20, P106, DOI 10.14529/hsm200113
   Miller KB, 2020, NUTR REV, V78, P29, DOI 10.1093/nutrit/nuz052
   Mirmiran Parvin, 2017, Prev Nutr Food Sci, V22, P263, DOI 10.3746/pnf.2017.22.4.263
   Moran NE, 2013, ARCH BIOCHEM BIOPHYS, V539, P171, DOI 10.1016/j.abb.2013.06.017
   Nie Y, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/5542342
   Noroozi Farzaneh, 2022, ScientificWorldJournal, V2022, P2908811, DOI 10.1155/2022/2908811
   Nweze C. C., 2021, GSC ADV RES REV, V9, P001, DOI https://doi.org/10.30574/gscarr.2021.9.3.0280
   Olszewski PK, 2019, CURR NUTR REP, V8, P120, DOI 10.1007/s13668-019-0270-5
   Oniszczuk A, 2021, MOLECULES, V26, DOI 10.3390/molecules26041172
   Padayatty SJ, 2003, J AM COLL NUTR, V22, P18, DOI 10.1080/07315724.2003.10719272
   Partula V, 2020, AM J CLIN NUTR, V112, P195, DOI 10.1093/ajcn/nqaa063
   Pavlidou E, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms232415898
   Perdomo F, 2012, NUTR HOSP, V27, P1542, DOI 10.3305/nh.2012.27.5.5908
   Petersen KS, 2017, CURR DEV NUTR, V1, DOI 10.3945/cdn.117.001289
   Poli A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13082810
   Przybylska S, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23041957
   Qiu ZC, 2020, COMPR REV FOOD SCI F, V19, P801, DOI 10.1111/1541-4337.12529
   Ramezani F, 2024, CLIN NUTR, V43, P65, DOI 10.1016/j.clnu.2023.11.005
   Rhee M, 2024, ENDOCRINOL METAB, V39, P511, DOI 10.3803/EnM.2023.1915
   Rosi A, 2019, NUTR METAB CARDIOVAS, V29, P544, DOI 10.1016/j.numecd.2019.03.003
   Saber A., 2016, Journal of Surgery, V4, P20, DOI [DOI 10.11648/J.JS.S.2016040201.15, 10.11648/j.js.s.2016040201]
   Sahin AW, 2019, FOOD RES INT, V126, DOI 10.1016/j.foodres.2019.108583
   Saini RK, 2016, FOOD RES INT, V89, P1, DOI 10.1016/j.foodres.2016.07.013
   Sanllorente A, 2021, J CLIN MED, V10, DOI 10.3390/jcm10245897
   Sebastian R.S., 2020, FSRG Diet. Data Briefs, V33, P1
   Sedaghat Z, 2024, BMC PUBLIC HEALTH, V24, DOI 10.1186/s12889-024-17707-7
   Senoner T, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092090
   Shahidi F, 2018, ANNU REV FOOD SCI T, V9, P345, DOI 10.1146/annurev-food-111317-095850
   Shaito A, 2022, FRONT BIOSCI-LANDMRK, V27, DOI 10.31083/j.fbl2703105
   Sikand G, 2020, AM J PREVENT CARDIOL, V4, DOI 10.1016/j.ajpc.2020.100106
   Slaght JL, 2021, BMJ OPEN DIAB RES CA, V9, DOI 10.1136/bmjdrc-2021-002134
   Smith AD, 2021, AM J CLIN NUTR, V113, P775, DOI 10.1093/ajcn/nqab013
   Sobenin IA, 2019, CHIN J NAT MEDICINES, V17, P721, DOI [10.1016/S1875-5364(19)30088-3, 10.1016/S1875-5364(19)30089-5]
   /stat.gov, Glowny Urzad Statystyczny
   Sue-Ling CB, 2022, J NUTR, V152, P1666, DOI 10.1093/jn/nxac079
   Swora-Cwynar E., 2022, Forum Zaburzen Metab, V13, P145
   Szczepanska Elzbieta, 2023, Int J Environ Res Public Health, V20, DOI 10.3390/ijerph20085442
   Tagliazucchi D, 2012, J AGR FOOD CHEM, V60, P11056, DOI 10.1021/jf302694a
   Thomas MS, 2023, ADV NUTR, V14, P44, DOI 10.1016/j.advnut.2022.10.002
   Topolska K, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18105327
   Vasquez EC, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/3086270
   Vélez-Terreros PY, 2024, FOODS, V13, DOI 10.3390/foods13091348
   Virani SS, 2021, CIRCULATION, V143, pe254, DOI 10.1161/CIR.0000000000000950
   Wang AYM, 2019, KIDNEY INT REP, V4, P814, DOI 10.1016/j.ekir.2019.03.007
   Wang L, 2024, PHYTOTHER RES, V38, P507, DOI 10.1002/ptr.8052
   Wang WT, 2023, MEDCOMM, V4, DOI 10.1002/mco2.212
   Wang Y, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000017095
   Wang Z, 2023, BMC CARDIOVASC DISOR, V23, DOI 10.1186/s12872-023-03567-3
   Weingärtner O, 2020, EUR HEART J, V41, P2629, DOI 10.1093/eurheartj/ehaa445
   who.int, REP FORM M MEMB STAT
   Woakowska-Kapon B., 2016, Folia Cardiol, V11, P318, DOI [10.5603/FC.2016.0044, DOI 10.5603/FC.2016.0044]
   World Health Organization Healthy Diet, 2019, Regional Office for the Eastern Mediterranean
   Yamada S, 2021, NUTRIENTS, V13, DOI 10.3390/nu13061751
   Yang B, 2022, NUTRIENTS, V14, DOI 10.3390/nu14204226
   Zamani M, 2023, NUTR J, V22, DOI 10.1186/s12937-023-00843-y
   Zhang HY, 2021, AM J CLIN NUTR, V114, P1837, DOI 10.1093/ajcn/nqab261
   Zhang H, 2014, NUTR RES REV, V27, P1, DOI 10.1017/S095442241300019X
   Zhang YB, 2021, J EPIDEMIOL COMMUN H, V75, P92, DOI 10.1136/jech-2020-214050
   Zhou L, 2024, CLIN NEUROPHARMACOL, V47, P87, DOI 10.1097/WNF.0000000000000593
NR 113
TC 0
Z9 0
U1 2
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD JUN
PY 2024
VL 14
IS 6
AR 296
DI 10.3390/metabo14060296
PG 16
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA WR8X0
UT WOS:001256703100001
PM 38921431
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sharma, P
   Mittal, P
   Arya, GC
AF Sharma, Priyanshu
   Mittal, Payal
   Arya, Girish Chandra
TI Unraveling the Mysteries of PCOS: A Comprehensive Investigation into
   Causes, Mechanisms, and Molecular Docking Analysis with Dolichos
   biflorus Linn.
SO CURRENT ANALYTICAL CHEMISTRY
LA English
DT Review; Early Access
DE PCOS; hyperinsulinemia; hyperandrogenism; genetic factors; etiology;
   molecular docking; binding energy
ID POLYCYSTIC-OVARY-SYNDROME; METABOLIC SYNDROME; HYPERANDROGENISM;
   DYSLIPIDEMIA; OBESITY; GROWTH; WOMEN; PATHOGENESIS; PREVALENCE;
   MANAGEMENT
AB Polycystic ovary syndrome (PCOS) presents as a complex endocrine and metabolic disorder characterized by anovulation, infertility, obesity, insulin resistance, and polycystic ovaries. Various factors contribute to PCOS risk, including lifestyle choices, diet, environmental pollutants, genetics, gut dysbiosis, neuroendocrine changes, and obesity. These factors can impact hyperinsulinemia, oxidative stress, hyperandrogenism, decreased folliculogenesis, and irregular menstrual cycles, ultimately contributing to metabolic syndrome. Conventional treatments for PCOS often carry significant side effects, prompting exploration into Ayurvedic alternatives. This review concentrates on molecular docking studies of phytochemicals sourced from Dolichos Biflorus Linn. against key proteins implicated in PCOS pathogenesis. Identification, modeling, and evaluation of target proteins were conducted, followed by the assessment of their interactions with selected phytochemicals and additional ADMET analysis. Molecular docking studies utilizing Auto Dock Vina software were then performed to forecast the binding affinities of these phytochemicals to the active sites of the specified targets.
C1 [Sharma, Priyanshu; Mittal, Payal; Arya, Girish Chandra] Chandigarh Univ, Dept Pharm, Mohali, India.
C3 Chandigarh University
RP Mittal, P (corresponding author), Chandigarh Univ, Dept Pharm, Mohali, India.
EM Payal.talk2@gmail.com
RI Arya, Girish chandra/ITV-3531-2023
OI Sharma, Priyanshu/0000-0001-6576-4544
FX The encouragement and inspiration to write the review that Chandigarh
   University gave the authors is greatly appreciated.
CR Ajmal N, 2019, EUR J OBSTET GYN R B, V3, DOI 10.1016/j.eurox.2019.100060
   Anagnostis P, 2018, METABOLISM, V86, P33, DOI 10.1016/j.metabol.2017.09.016
   Arentz S, 2017, PHYTOTHER RES, V31, P1330, DOI 10.1002/ptr.5858
   Armanini D, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23084110
   Azziz R, 2018, OBSTET GYNECOL, V132, P321, DOI 10.1097/AOG.0000000000002698
   Bar-Tana J, 2023, TRENDS ENDOCRIN MET, V34, P135, DOI 10.1016/j.tem.2023.01.001
   Barrea L, 2023, J PINEAL RES, V74, DOI 10.1111/jpi.12844
   Barrea L, 2021, NUTRIENTS, V13, DOI 10.3390/nu13113925
   Barrea L, 2018, NUTR RES REV, V31, P291, DOI 10.1017/S0954422418000136
   Barthelmess Erin K, 2014, Front Biosci (Elite Ed), V6, P104
   Basu S, 2017, CHEM CENT J, V11, DOI 10.1186/s13065-017-0349-2
   Bayona A, 2022, HUM REPROD UPDATE, V28, P501, DOI 10.1093/humupd/dmac011
   Bednarska S, 2017, ADV CLIN EXP MED, V26, P359, DOI 10.17219/acem/59380
   Belenkaia LV, 2019, MINERVA GINECOL, V71, P211, DOI 10.23736/S0026-4784.19.04404-6
   Brazert M, 2015, GINEKOL POL, V86, P890, DOI 10.17772/gp/60708
   Cappelli V, 2017, EUR REV MED PHARMACO, V21, P15
   Cataldo NA, 1997, SEMIN REPROD ENDOCR, V15, P123, DOI 10.1055/s-2007-1016295
   Catteau-Jonard S, 2012, ENDOCR DEV, V22, P181, DOI 10.1159/000326688
   Cena H, 2020, J CLIN ENDOCR METAB, V105, pE2695, DOI 10.1210/clinem/dgaa285
   Charifson MA, 2019, EVOL MED PUBLIC HLTH, P50, DOI 10.1093/emph/eoz011
   Chaudhary H, 2021, J OVARIAN RES, V14, DOI 10.1186/s13048-021-00879-w
   Che Y, 2023, J CLIN MED, V12, DOI 10.3390/jcm12041500
   Dabravolski SA, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22083923
   Daziroglu MEÇ, 2023, CURR NUTR REP, V12, P191, DOI 10.1007/s13668-023-00451-6
   de Loos AD, 2022, EUR J ENDOCRINOL, V186, P53, DOI 10.1530/EJE-21-0669
   Duleba AJ, 2012, STEROIDS, V77, P306, DOI 10.1016/j.steroids.2011.11.014
   Escobar-Morreale HF, 2018, NAT REV ENDOCRINOL, V14, P270, DOI 10.1038/nrendo.2018.24
   Ganie MA, 2020, INT J GYNECOL OBSTET, V149, P231, DOI 10.1002/ijgo.13125
   Gleicher N, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10071505
   Glueck CJ, 2019, METABOLISM, V92, P108, DOI 10.1016/j.metabol.2018.11.002
   Guan C, 2022, FERTIL STERIL, V117, P924, DOI 10.1016/j.fertnstert.2022.03.009
   Guo F, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.892125
   Ibáñez L, 2023, TRENDS MOL MED, V29, P354, DOI 10.1016/j.molmed.2023.02.006
   Joham AE, 2022, LANCET DIABETES ENDO, V10, P668, DOI 10.1016/S2213-8587(22)00163-2
   Kakoly NS, 2019, EXPERT REV ENDOCRINO, V14, P23, DOI 10.1080/17446651.2019.1556094
   Kamboj P, 2023, CLIN EXP DERMATOL, V48, P617, DOI 10.1093/ced/llad020
   Kazemi M, 2021, ADV NUTR, V12, P161, DOI 10.1093/advances/nmaa092
   Kazemi M, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101387
   Khan MJ, 2019, APPL CLIN GENET, V12, P249, DOI 10.2147/TACG.S200341
   Kim Jin Ju, 2013, Obstet Gynecol Sci, V56, P137
   Krishnan A, 2017, J ENDOCRINOL, V232, pR99, DOI 10.1530/JOE-16-0405
   Kruszewska J, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19042099
   Kshetrimayum C, 2019, J TURK-GER GYNECOL A, V20, P255, DOI 10.4274/jtgga.galenos.2019.2018.0142
   Legro RS, 2012, SEMIN REPROD MED, V30, P496, DOI 10.1055/s-0032-1328878
   Li MW, 2022, SIGNAL TRANSDUCT TAR, V7, DOI 10.1038/s41392-022-01073-0
   Li S, 2023, NPJ BIOFILMS MICROBI, V9, DOI 10.1038/s41522-023-00415-2
   Lindner PG, 2021, CLIN OBSTET GYNECOL, V64, P48, DOI 10.1097/GRF.0000000000000598
   Liu Q, 2019, TAIWAN J OBSTET GYNE, V58, P447, DOI 10.1016/j.tjog.2019.05.003
   Liu S, 2022, TRIALS, V23, DOI 10.1186/s13063-022-06586-1
   Liu ZT, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.713356
   Lizneva D, 2016, FERTIL STERIL, V106, P6, DOI 10.1016/j.fertnstert.2016.05.003
   Ii JMA, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11040647
   Macut D, 2013, FRONT HORM RES, V40, P51, DOI 10.1159/000341683
   Malini NA, 2021, ACTA ENDOCRINOL-BUCH, V17, P313, DOI 10.4183/aeb.2021.313
   Meier RK, 2018, NURS CLIN N AM, V53, P407, DOI 10.1016/j.cnur.2018.04.008
   Mirabelli M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041066
   Nirumand MC, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19030765
   Nugent BM, 2012, HORM METAB RES, V44, P577, DOI 10.1055/s-0032-1312593
   Padmanabhan V, 2011, SEMIN REPROD MED, V29, P173, DOI 10.1055/s-0031-1275519
   Paris VR, 2021, J ENDOCR SOC, V5, DOI 10.1210/jendso/bvab060
   Parker J, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19031336
   Pasquali R, 2018, FRONT HORM RES, V49, P114, DOI 10.1159/000485995
   Patel S, 2018, J STEROID BIOCHEM, V182, P27, DOI 10.1016/j.jsbmb.2018.04.008
   Pei ZL, 2022, HUM REPROD, V37, P1959, DOI 10.1093/humrep/deac156
   Rae M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0056263
   Rashid R, 2022, TAIWAN J OBSTET GYNE, V61, P40, DOI 10.1016/j.tjog.2021.11.009
   Reckelhoff JF, 2022, KIDNEY360, V3, P1449, DOI 10.34067/KID.0002052022
   Rodriguez Paris Valentina, 2019, Med Sci (Basel), V7, DOI 10.3390/medsci7090089
   Rosenfield RL, 2016, ENDOCR REV, V37, P467, DOI 10.1210/er.2015-1104
   Rudnicka E, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22073789
   Saadia Zaheera, 2020, Med Arch, V74, P289, DOI 10.5455/medarh.2020.74.289-293
   Sadeghi HM, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020583
   Saha S, 2015, PHARM BIOL, V53, P16, DOI 10.3109/13880209.2014.909501
   Saxena Yogesh, 2014, Ayu, V35, P442, DOI 10.4103/0974-8520.159022
   Shahid R, 2022, J FOOD BIOCHEM, V46, DOI 10.1111/jfbc.14117
   Sharma A, 2021, MED CLIN N AM, V105, P1099, DOI 10.1016/j.mcna.2021.06.008
   Shele Grei, 2020, J Funct Morphol Kinesiol, V5, DOI 10.3390/jfmk5020035
   Siddiqui S, 2022, J ASSIST REPROD GEN, V39, P2439, DOI 10.1007/s10815-022-02625-7
   Singh S, 2023, J CLIN MED, V12, DOI 10.3390/jcm12041454
   Snider AP, 2019, REPRODUCTION, V158, pR79, DOI 10.1530/REP-18-0583
   Stubbs SA, 2013, J CLIN ENDOCR METAB, V98, P3298, DOI 10.1210/jc.2013-1378
   Szczesnowicz A, 2023, J CLIN MED, V12, DOI 10.3390/jcm12185915
   Szydlarska D, 2017, ADV CLIN EXP MED, V26, P555, DOI 10.17219/acem/61987
   Thurston L, 2019, J CLIN PATHOL, V72, P579, DOI 10.1136/jclinpath-2018-205579
   Tong C, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.1091147
   Torre A, 2007, J Gynecol Obstet Biol Reprod (Paris), V36, P423
   van der Ham K, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1245106
   Wang Z, 2021, NUTRIENTS, V13, DOI 10.3390/nu13103526
   Wekker V, 2020, HUM REPROD UPDATE, V26, P942, DOI 10.1093/humupd/dmaa029
   Wild RA, 2012, STEROIDS, V77, P295, DOI 10.1016/j.steroids.2011.12.002
   Witchel SF, 2019, CURR OPIN PEDIATR, V31, P562, DOI 10.1097/MOP.0000000000000778
   Witchel SF, 2020, PEDIATR RES, V87, P353, DOI 10.1038/s41390-019-0615-1
   Woodward A, 2020, ADV EXP MED BIOL, V1228, P123, DOI 10.1007/978-981-15-1792-1_8
   Xia Q, 2023, HELIYON, V9, DOI 10.1016/j.heliyon.2023.e13024
   Xu YL, 2022, J HEALTHC ENG, V2022, DOI 10.1155/2022/9240569
   Zeng X, 2020, CLIN CHIM ACTA, V502, P214, DOI 10.1016/j.cca.2019.11.003
   Zhang JX, 2012, HUM REPROD, V27, P2484, DOI 10.1093/humrep/des191
   Zhang YH, 2020, J ENDOCRINOL, V246, P247, DOI 10.1530/JOE-20-0155
   Zhao H, 2023, J OVARIAN RES, V16, DOI 10.1186/s13048-022-01091-0
   Zhu TT, 2022, J CLIN ENDOCR METAB, V107, pE899, DOI 10.1210/clinem/dgab757
NR 100
TC 0
Z9 0
U1 2
U2 7
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-4110
EI 1875-6727
J9 CURR ANAL CHEM
JI Curr. Anal. Chem.
PD 2024 SEP 12
PY 2024
DI 10.2174/0115734110312022240903060337
EA SEP 2024
PG 28
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA F9C7B
UT WOS:001312715000001
DA 2025-06-11
ER

PT J
AU Nna, VU
   McGrowder, D
   Nwokocha, C
AF Nna, Victor Udo
   McGrowder, Donovan
   Nwokocha, Chukwuemeka
TI Nutraceutical management of metabolic syndrome as a palliative and a
   therapeutic to coronavirus disease (COVID) crisis
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Review
DE Metabolic syndrome; coronavirus; obesity; hypertension; diabetes
ID TYPE-2 DIABETES-MELLITUS; VERNONIA-AMYGDALINA; DOUBLE-BLIND; PROPOLIS
   EXTRACT; AQUEOUS EXTRACTS; GONGRONEMA LATIFOLIUM; CHEMICAL-COMPOSITION;
   ETHANOLIC EXTRACT; OXIDATIVE STRESS; ALOE-VERA
AB The global market for medicinal plants and herbs is on the increase due to their desirability, efficacy, and less adverse effects as complementary and alternative medications to the orthodox pharmaceuticals, perhaps due to their natural components and qualities. Metabolic syndromes are managed with changes in diet, exercise, lifestyle modifications and the use of pharmacological agents. Plants are now known to have potent antioxidant and cholinergic activities which are relevant to the management of several metabolic syndromes, which are unfortunately, co-morbidity factors in the coronavirus disease crisis. This review will focus on the biological activities of some plant products used as complementary and alternative medicines in the management of metabolic syndromes, and on their reported antiviral, antithrombotic, angiotensin-converting enzyme inhibitory properties, which are integral to their usage in the management of viral infections and may give an avenue for prophylactic and therapeutics especially in the absence of vaccines/formulated antiviral therapies.
C1 [Nna, Victor Udo] Univ Calabar, Coll Med Sci, Dept Physiol, PMB 1115, Calabar, Cross River Sta, Nigeria.
   [McGrowder, Donovan] Univ West Indies, Dept Pathol, Mona, Jamaica.
   [Nwokocha, Chukwuemeka] Univ West Indies, Physiol Sect, Dept Basic Med Sci, Kingston 7, Mona, Jamaica.
C3 University of Calabar; University West Indies Mona Jamaica; University
   West Indies Mona Jamaica
RP Nna, VU (corresponding author), Univ Calabar, Coll Med Sci, Dept Physiol, PMB 1115, Calabar, Cross River Sta, Nigeria.; Nwokocha, C (corresponding author), Univ West Indies, Physiol Sect, Dept Basic Med Sci, Kingston 7, Mona, Jamaica.
EM victorudon@unical.edu.ng; chukwuemeka.nwokocha@uwimona.edu.jm
RI McGrowder, Donovan/AAT-1538-2021; Nna, Victor/D-8197-2015
OI Nna, Victor/0000-0001-7616-9468; Nwokocha,
   Chukwuemeka/0000-0001-7092-9382
CR Aba P.E., 2016, NOTULAE SCI BIOL, V8
   Abdulazeez M. A., 2013, African Journal of Biochemistry Research, V7, P165
   Adaramoye OA, 2008, VASC HEALTH RISK MAN, V4, P235, DOI 10.2147/vhrm.2008.04.01.235
   Adeoye AT, 2017, FASEB J, V31
   Adesanoye OA, 2016, TOXICOL IND HEALTH, V32, P47, DOI 10.1177/0748233713498436
   Adesanoye OA, 2010, EXP TOXICOL PATHOL, V62, P197, DOI 10.1016/j.etp.2009.05.008
   Afsharpour F, 2019, COMPLEMENT THER MED, V43, P283, DOI 10.1016/j.ctim.2019.03.001
   Agustinah W, 2016, J FOOD QUALITY, V39, P370, DOI 10.1111/jfq.12206
   Ajibola CF, 2011, PLANT FOOD HUM NUTR, V66, P320, DOI 10.1007/s11130-011-0257-x
   Ajiboye BO, 2019, PHARM BIOL, V57, P604, DOI 10.1080/13880209.2019.1657907
   Ajiboye BO, 2018, J EVID-BASED INTEGR, V23, DOI 10.1177/2515690X18770630
   Akinyemi AJ, 2014, J MED FOOD, V17, P317, DOI 10.1089/jmf.2012.0264
   Akpaso M. I., 2011, British Journal of Medicine and Medical Research, V1, P24
   Al-Hariri M, 2011, DIABETES METAB SYNDR, V4, P377, DOI 10.2147/DMSO.S24159
   Al-Hindi B, 2019, BMC COMPLEM ALTERN M, V19, DOI 10.1186/s12906-019-2573-x
   Al-Hindi Bassel, 2016, Med Sci (Basel), V4, DOI 10.3390/medsci4020009
   Al-Rasheed N, 2014, J OLEO SCI, V63, P839, DOI 10.5650/jos.ess14027
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Vazquez-Prieto MA, 2010, J AGR FOOD CHEM, V58, P6630, DOI 10.1021/jf1006819
   Alinejad-Mofrad S, 2015, J DIABETES METAB DIS, V14, DOI 10.1186/s40200-015-0137-2
   Amor S, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010153
   Ankri S, 1999, MICROBES INFECT, V1, P125, DOI 10.1016/S1286-4579(99)80003-3
   Arora MK, 2019, J DIET SUPPL, V16, P227, DOI 10.1080/19390211.2018.1449159
   Arreola R, 2015, J IMMUNOL RES, V2015, DOI 10.1155/2015/401630
   Asante DB, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/8252741
   Asante DB, 2019, BIOMED PHARMACOTHER, V111, P1187, DOI 10.1016/j.biopha.2018.12.147
   Atangwho IJ, 2009, AFR J BIOTECHNOL, V8, P4685
   Atangwho IJ, 2013, FOOD CHEM, V141, P3428, DOI 10.1016/j.foodchem.2013.06.047
   Attia AA, 2012, PESTIC BIOCHEM PHYS, V103, P87, DOI 10.1016/j.pestbp.2012.04.002
   Babatunde IR, 2015, J INTERCULT ETHNOPHA, V4, P102, DOI 10.5455/jice.20150202023615
   Babu S.N., 2019, RES J PHARM TECHNOLO, V12
   Bankova V, 2014, PHYTOMEDICINE, V21, P1432, DOI 10.1016/j.phymed.2014.04.026
   Bansal M, 2020, DIAB MET SYND CLIN R, V14, P247, DOI 10.1016/j.dsx.2020.03.013
   Basu A, 2010, J NUTR, V140, P1582, DOI 10.3945/jn.110.124701
   Beltrán-Sánchez H, 2013, J AM COLL CARDIOL, V62, P697, DOI 10.1016/j.jacc.2013.05.064
   Beshel Justin Atiang, 2020, Journal of Basic and Clinical Physiology and Pharmacology, V31
   Bhattacharya S, 2019, BIOMED PHARMACOTHER, V111, P1302, DOI 10.1016/j.biopha.2019.01.036
   Búfalo MC, 2013, J ETHNOPHARMACOL, V149, P84, DOI 10.1016/j.jep.2013.06.004
   Cásedas G, 2017, FOOD FUNCT, V8, P4187, DOI [10.1039/c7fo01205e, 10.1039/C7FO01205E]
   Ch'ng YS, 2017, PHARM BIOL, V55, P2083, DOI 10.1080/13880209.2017.1357735
   Chaa S, 2019, REV BRAS FARMACOGN, V29, P294, DOI 10.1016/j.bjp.2019.01.005
   Chainani-Wu N, 2003, J ALTERN COMPLEM MED, V9, P161, DOI 10.1089/107555303321223035
   Chime Salome Amarachi, 2014, Journal of Dietary Supplements, V11, P7, DOI 10.3109/19390211.2013.859212
   Cho SJ, 2019, J CANCER PREV, V24, P112, DOI 10.15430/JCP.2019.24.2.112
   Choi HC, 2013, NUTRITION, V29, P1110, DOI 10.1016/j.nut.2013.02.015
   Choi JG, 2019, AM J CHINESE MED, V47, P1307, DOI 10.1142/S0192415X19500678
   Choudhary D.K., 2020, TOXICOL RES-UK, V9
   Choudhary M, 2014, J FOOD SCI TECH MYS, V51, P90, DOI 10.1007/s13197-011-0459-0
   Choudhary Prema Ram, 2018, Journal of Dietary Supplements, V15, P499, DOI 10.1080/19390211.2017.1358233
   Çilenk KT, 2016, EXP MOL PATHOL, V101, P207, DOI 10.1016/j.yexmp.2016.08.004
   Dabaghzadeh F, 2014, EXPERT OPIN DRUG SAF, V13, P859, DOI 10.1517/14740338.2014.914170
   Devaraj S, 2013, METAB SYNDR RELAT D, V11, P35, DOI 10.1089/met.2012.0066
   Duchnowicz P, 2018, BIOMED RES INT, V2018, DOI 10.1155/2018/5670145
   Ebong P. E., 2008, American Journal of Biochemistry and Biotechnology, V4, P239
   Egedigwe CA, 2016, PHARM BIOL, V54, P3232, DOI 10.1080/13880209.2016.1216135
   Ekeleme-Egedigwe CA, 2017, ACTA SCI POLON-TECHN, V16, P431, DOI [10.17306/J.AFS.0504, 10.17306/j.afs.0504, 10.17306/J.AFS.2017.0504]
   Ekong MB, 2014, METAB BRAIN DIS, V29, P521, DOI 10.1007/s11011-013-9453-8
   El-Mehi AE, 2020, FOLIA MORPHOL, V79, P690, DOI 10.5603/FM.a2019.0139
   El-Sayed ESM, 2009, PAK J PHARM SCI, V22, P168
   Elks CM, 2015, OBESITY, V23, P573, DOI 10.1002/oby.20926
   ElMazoudy RH, 2011, PESTIC BIOCHEM PHYS, V101, P175, DOI 10.1016/j.pestbp.2011.09.003
   Erasto P, 2007, PHARM BIOL, V45, P195, DOI 10.1080/13880200701213070
   Ernsberger P, 2007, AM J HYPERTENS, V20, P866, DOI 10.1016/j.amjhyper.2007.02.015
   Erukainure OL, 2019, J FOOD BIOCHEM, V43, DOI 10.1111/jfbc.12737
   Erukainure OL, 2019, METAB BRAIN DIS, V34, P721, DOI 10.1007/s11011-018-0363-7
   Eteng M. U., 2008, Asian Journal of Biochemistry, V3, P228
   Farooqui T, 2010, CURR NUTR FOOD SCI, V6, P186, DOI 10.2174/157340110792389136
   Fasakin CF, 2011, FOOD RES INT, V44, P2435, DOI 10.1016/j.foodres.2010.12.019
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Gansukh E, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-35935-x
   Gao WN, 2018, DIABETES THER, V9, P101, DOI 10.1007/s13300-017-0341-9
   Gargouri W, 2019, LWT-FOOD SCI TECHNOL, V111, P328, DOI 10.1016/j.lwt.2019.05.044
   Gbolade A, 2012, J ETHNOPHARMACOL, V144, P1, DOI 10.1016/j.jep.2012.07.018
   Giovanelli G, 2009, FOOD CHEM, V112, P903, DOI 10.1016/j.foodchem.2008.06.066
   Gomez-Arbelaez Diego, 2013, Mediators Inflamm, V2013, P285795, DOI 10.1155/2013/285795
   Gong P, 2020, TOXIN REV, V39, P147, DOI 10.1080/15569543.2018.1480497
   Grace MH, 2009, PHYTOMEDICINE, V16, P406, DOI 10.1016/j.phymed.2009.02.018
   Granados-Pineda J, 2018, MOLECULES, V23, DOI 10.3390/molecules23040852
   Grundy SM, 2018, ENDOCRINOL SER, P71, DOI 10.1007/978-3-319-44433-8_3
   Grundy SM, 2015, EUR J CLIN INVEST, V45, P1209, DOI 10.1111/eci.12519
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Gupta VK, 2019, J CELL PHYSIOL, V234, P18329, DOI 10.1002/jcp.28466
   Gupta YK, 2010, INDIAN J EXP BIOL, V48, P1069
   Hamal S, 2020, EXP THER MED, V19, P1485, DOI 10.3892/etm.2019.8377
   Han CY, 2011, ANTIOXID REDOX SIGN, V14, P187, DOI 10.1089/ars.2010.3190
   Hashem RM, 2008, EUR J GASTROEN HEPAT, V20, P995, DOI 10.1097/MEG.0b013e3282fdf65f
   Hasibuan PAZ, 2020, HELIYON, V6, DOI 10.1016/j.heliyon.2020.e04449
   Hesami S, 2019, CASP J INTERN MED, V10, P48, DOI 10.22088/cjim.10.1.48
   Higashikawa F, 2012, CLIN NUTR, V31, P261, DOI 10.1016/j.clnu.2011.10.008
   Hosseini Mahmoud, 2007, Pathophysiology, V14, P109, DOI 10.1016/j.pathophys.2007.07.002
   Huang I, 2020, DIAB MET SYND CLIN R, V14, P395, DOI 10.1016/j.dsx.2020.04.018
   Huang WY, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21051575
   Huleihel M, 2002, ISR MED ASSOC J, V4, P923
   Huseini HF, 2012, PLANTA MED, V78, P311, DOI 10.1055/s-0031-1280474
   Hutchins E, 2020, EXP THER MED, V19, P1468, DOI 10.3892/etm.2019.8373
   Ibrahim KA, 2019, PESTIC BIOCHEM PHYS, V159, P127, DOI 10.1016/j.pestbp.2019.06.006
   Imafidon CE, 2018, TOXICOL REP, V5, P324, DOI 10.1016/j.toxrep.2018.02.009
   Jeremic JN, 2019, MOL CELL BIOCHEM, V460, P151, DOI 10.1007/s11010-019-03577-w
   Jiao XY, 2019, J NUTR BIOCHEM, V64, P88, DOI 10.1016/j.jnutbio.2018.07.008
   Johnson SA, 2017, FOOD FUNCT, V8, P372, DOI [10.1039/c6fo01216g, 10.1039/C6FO01216G]
   Johnson SA, 2015, J ACAD NUTR DIET, V115, P369, DOI 10.1016/j.jand.2014.11.001
   Joshi SS, 2019, FOOD MICROBIOL, V82, P202, DOI 10.1016/j.fm.2019.02.001
   Joshi SS, 2016, FOOD ENVIRON VIROL, V8, P235, DOI 10.1007/s12560-016-9247-3
   Kalhotra P, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10020305
   Kang LJ, 2010, PHYTOTHER RES, V24, P1554, DOI 10.1002/ptr.3147
   Karimi N, 2015, IRAN J CANCER PREV, V8, DOI 10.17795/ijcp-3856
   Khalifa HO, 2015, PHYTOTHER RES, V29, P1791, DOI 10.1002/ptr.5436
   Kim K, 2009, PHYTOMEDICINE, V16, P856, DOI 10.1016/j.phymed.2009.02.014
   Kim MK, 2010, EXP GERONTOL, V45, P419, DOI 10.1016/j.exger.2010.03.005
   Kumar R, 2013, DIABET METAB SYND OB, V6, P49, DOI 10.2147/DMSO.S38888
   Kumar Sandeep, 2017, BMC Res Notes, V10, P60, DOI 10.1186/s13104-017-2385-3
   Kumari S, 2017, BIOMED PHARMACOTHER, V95, P252, DOI 10.1016/j.biopha.2017.08.065
   Lakka TA, 2007, APPL PHYSIOL NUTR ME, V32, P76, DOI 10.1139/h06-113
   Laux A, 2019, EXPERT OPIN DRUG DEL, V16, P1283, DOI 10.1080/17425247.2019.1675633
   Lefsih K., 2018, Advances in Applied Chemistry and Biochemistry, DOI [10.33513/acbc/1801-03, DOI 10.33513/ACBC/1801-03]
   Li D, 2015, J NUTR, V145, P742, DOI 10.3945/jn.114.205674
   Li Y., 2014, BASIC CLIN PHARMACOL, V115
   Li Y, 2017, NUTRIENTS, V9, DOI 10.3390/nu9070728
   Li YJ, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/981896
   Lin Liang-Tzung, 2014, J Tradit Complement Med, V4, P24, DOI 10.4103/2225-4110.124335
   Lissiman Elizabeth, 2014, Cochrane Database Syst Rev, pCD006206, DOI 10.1002/14651858.CD006206.pub4
   Madkor HR, 2011, BRIT J NUTR, V105, P1210, DOI 10.1017/S0007114510004927
   Madzuki I.N., 2019, PHYTOTHERAPY RES PTR, V33
   Maeda T., 2019, EXP THER MED, V18
   Márquez N, 2004, J PHARMACOL EXP THER, V308, P993, DOI 10.1124/jpet.103.060673
   Matsui T, 2004, BIOL PHARM BULL, V27, P1797, DOI 10.1248/bpb.27.1797
   Matsumoto S, 2016, J NUTR, V146, p427S, DOI 10.3945/jn.114.202424
   Melino S, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071581
   Meneguzzo F., 2020, ACCELERATED PRODUCTI, DOI [10.20944/preprints202003.0386.v1, DOI 10.20944/PREPRINTS202003.0386.V1]
   Miki S., 2020, EXP THER MED, V19
   Mofrad MD, 2019, J NUTR, V149, P605, DOI 10.1093/jn/nxy310
   Momoh M. A., 2012, Asian Pacific Journal of Tropical Biomedicine, V2, P181, DOI 10.1016/S2221-1691(12)60038-0
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Mousa SA, 2010, METHODS MOL BIOL, V663, P229, DOI 10.1007/978-1-60761-803-4_9
   Mykkänen OT, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0114790
   Nair AR, 2017, FOOD FUNCT, V8, P4118, DOI [10.1039/c7fo00815e, 10.1039/C7FO00815E]
   Nammi S, 2009, BASIC CLIN PHARMACOL, V104, P366, DOI 10.1111/j.1742-7843.2008.00362.x
   Nna V.U., 2018, FOOD CHEM TOXICOLOGY, V120
   Nna VU, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8100465
   Nna VU, 2018, LIFE SCI, V211, P40, DOI 10.1016/j.lfs.2018.09.018
   Noor A, 2017, PHARMACOGN RES, V9, pS99, DOI 10.4103/pr.pr_75_17
   Nurhamizah Ibrahim Nurhamizah Ibrahim, 2016, Malaysian Journal of Analytical Sciences, V20, P413
   Nwokocha C R, 2011, Niger J Physiol Sci, V26, P213
   Nwokocha C.R., 2012, FOOD CHEM TOXICOL, V50
   Nwokocha CR, 2012, FOOD CHEM TOXICOL, V50, P222, DOI 10.1016/j.fct.2011.11.003
   NWOKOCHA CR, 2020, AM J HYPERTENS, V33
   NWOSU MO, 1995, MYCOSES, V38, P191, DOI 10.1111/j.1439-0507.1995.tb00048.x
   Oboh G, 2019, J DIET SUPPL, V16, P105, DOI 10.1080/19390211.2018.1438553
   Ochiai M, 2019, J FOOD SCI, V84, P339, DOI 10.1111/1750-3841.14437
   Ogbuagu E. O., 2019, AJRIMPS, V7, P1, DOI [DOI 10.9734/AJRIMPS/2019/V7I330122, 10.9734/ajrimps/2019/v7i330122]
   Ojo OA, 2020, J DIABETES METAB DIS, V19, P469, DOI 10.1007/s40200-020-00533-0
   Omar S., 2020, CHEMRXIV
   Ong KW, 2011, J ETHNOPHARMACOL, V133, P598, DOI 10.1016/j.jep.2010.10.046
   Osés SM, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9010075
   Owolabi MA., 2008, J Complement Integr Med, V5, P1, DOI [10.2202/1553-3840.1152, DOI 10.2202/1553-3840.1152]
   Owu D., 2012, W INDIAN MED J, V61
   Padiya R, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-53
   Panagiotakos DB, 2004, AM HEART J, V147, P106, DOI 10.1016/S0002-8703(03)00442-3
   Park MY, 2009, BIOSCI BIOTECH BIOCH, V73, P828, DOI 10.1271/bbb.80714
   Pérez-Torres I, 2016, MOLECULES, V21, DOI 10.3390/molecules21111425
   Pimenta AM, 2015, CLIN NUTR, V34, P508, DOI 10.1016/j.clnu.2014.06.002
   Prabjone R, 2006, CLIN HEMORHEOL MICRO, V35, P359
   Putta S, 2018, CURR MED CHEM, V25, P5347, DOI 10.2174/0929867325666171206101945
   Rahimlou M, 2019, J DIABETES METAB DIS, V18, P119, DOI 10.1007/s40200-019-00397-z
   Rahoui W., 2018, J FUNCT FOODS, V48
   Rajasekaran S, 2006, CLIN EXP PHARMACOL P, V33, P232, DOI 10.1111/j.1440-1681.2006.04351.x
   Rajasekaran S, 2004, J MED FOOD, V7, P61, DOI 10.1089/109662004322984725
   Rasool A, 2017, PAK J PHARM SCI, V30, P1341
   Rezazadeh F., 2016, J DENT, V17
   Riaz M., 2016, SPRINGERBRIEF FOOD, DOI DOI 10.1007/978-3-319-26456-1_1
   Rivera-Yañez N, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/4360356
   Roopchand DE, 2013, PHARMACOL RES, V68, P59, DOI 10.1016/j.phrs.2012.11.008
   Lima ARR, 2019, ARQ BRAS CARDIOL, V112, P163, DOI 10.5935/abc.20180259
   Safa O., 2020, TRIALS, V21
   Saliu JA, 2012, J FOOD BIOCHEM, V36, P569, DOI 10.1111/j.1745-4514.2011.00576.x
   Samadi N, 2017, J INTEGR MED-JIM, V15, P124, DOI 10.1016/S2095-4964(17)60315-7
   San Chang J., 2013, J ETHNOPHARMACOL, V145
   Schnitzler P, 2010, PHYTOTHER RES, V24, pS20, DOI 10.1002/ptr.2868
   Sefi Mediha, 2019, Pharmaceutical and Biomedical Research, V5, P29, DOI 10.18502/pbr.v5i3.2116
   SERKEDJIEVA J, 1992, J NAT PROD, V55, P294, DOI 10.1021/np50081a003
   Seymour EM, 2011, J MED FOOD, V14, P1511, DOI 10.1089/jmf.2010.0292
   Sforcin J.M., 2016, PHYTOTHERAPY RES PTR, V30
   Shaikh K., 2020, EXP THER MED, V19
   Shakib Z., 2019, PHYTOTHERAPY RES PTR, V33
   SHELTON RM, 1991, INT J DERMATOL, V30, P679, DOI 10.1111/j.1365-4362.1991.tb02607.x
   Shi M, 2017, J FUNCT FOODS, V30, P16, DOI 10.1016/j.jff.2016.12.036
   Shin Eunju, 2011, Immune Netw, V11, P59, DOI 10.4110/in.2011.11.1.59
   Shouk R., 2014, NUTR RES NEW YORK NY, V34
   Somanadhan B, 1999, J ETHNOPHARMACOL, V65, P103, DOI 10.1016/S0378-8741(98)00201-3
   Sonmez M.F., 2016, BIOMEDICINE PHARMACO, V79
   Stull AJ, 2010, J NUTR, V140, P1764, DOI 10.3945/jn.110.125336
   Su XM, 2017, MOLECULES, V22, DOI 10.3390/molecules22020312
   Subramanian S., 2020, SOME NEEM LEAVES EXT
   Suksomboon N, 2016, J CLIN PHARM THER, V41, P180, DOI 10.1111/jcpt.12382
   Szliszka E., 2013, INHIBITION INFLAMMAT
   Tabatabaei S.R.F., 2017, BIOMEDICINE PHARMACO, V96
   Taiwo IA., 2010, Researcher, V2, P76
   Takeshita M, 2009, J BIOL CHEM, V284, P21165, DOI 10.1074/jbc.M109.004945
   Talas ZS, 2014, CLIN EXP HYPERTENS, V36, P492, DOI 10.3109/10641963.2013.863322
   Talib WH, 2017, NUTRITION, V43-44, P89, DOI 10.1016/j.nut.2017.06.015
   Tanaka M., 2006, BIOL PHARM BULL, V29
   Tang Zhan-gui, 2000, Hunan Yike Daxue Xuebao, V25, P27
   Thomas S, 2015, IRAN J MED SCI, V40, P45
   Thomson M, 2003, CURR CANCER DRUG TAR, V3, P67, DOI 10.2174/1568009033333736
   Toda K., 2016, J NAT MED-TOKYO, V70
   Ugochukwu NH, 2003, LIFE SCI, V73, P1925, DOI 10.1016/S0024-3205(03)00543-5
   Ugochukwu NH, 2002, FITOTERAPIA, V73, P612, DOI 10.1016/S0367-326X(02)00218-6
   Ugwu C. E., 2011, African Journal of Biochemistry Research, V5, P28
   Usman U. Z., 2017, Journal of Medicine and Biomedical Research, V16, P15
   Vendrame S, 2014, BRIT J NUTR, V111, P194, DOI 10.1017/S0007114513002390
   Wan QY, 2019, FOOD SCI NUTR, V7, P2451, DOI 10.1002/fsn3.1117
   Wang J, 2017, ANN NY ACAD SCI, V1398, P83, DOI 10.1111/nyas.13375
   Wang K, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/127672
   Wang WT, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0235717
   Wiseman W, 2011, CAN J PHYSIOL PHARM, V89, P67, DOI [10.1139/Y10-101, 10.1139/y10-101]
   Wlosinska M, 2019, INT WOUND J, V16, P1487, DOI 10.1111/iwj.13220
   Woo KJ, 2005, FEBS LETT, V579, P705, DOI 10.1016/j.febslet.2004.12.048
   Wu T, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0077585
   Yagi A, 2002, PLANTA MED, V68, P957, DOI 10.1055/s-2002-35666
   Yagi Akira, 2009, Saudi Pharm J, V17, P209, DOI 10.1016/j.jsps.2009.08.007
   Yang M., 2014, BMC COMPLEM ALTERN M, V14
   Yun N, 2009, FOOD CHEM TOXICOL, V47, P1341, DOI 10.1016/j.fct.2009.03.013
   Zhang H., 2015, EVID-BASED COMPL ALT
   Zhao L., 2016, INT J ENV RES PUB HE, V13
   Zhao W., 2018, FOOD FUNCT, V9
   Zhu J, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/5692962
NR 226
TC 7
Z9 7
U1 1
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD SEP 3
PY 2023
VL 129
IS 5
BP 1123
EP 1142
DI 10.1080/13813455.2021.1903041
EA MAR 2021
PG 20
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA S1DT2
UT WOS:000633235500001
PM 33770443
DA 2025-06-11
ER

PT J
AU Zhang, ZG
   Zhou, SS
   Jiang, X
   Wang, YH
   Li, FS
   Wang, YG
   Zheng, Y
   Cai, L
AF Zhang, Zhiguo
   Zhou, Shanshan
   Jiang, Xin
   Wang, Yue-Hui
   Li, Fengsheng
   Wang, Yong-Gang
   Zheng, Yang
   Cai, Lu
TI The role of the Nrf2/Keap1 pathway in obesity and metabolic syndrome
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Article
DE Nrf2/Keap1; Metabolic homeostasis; Obesity; Insulin resistance; Reactive
   oxygen species
ID DEPENDENT HEPATIC LIPOGENESIS; DIET-INDUCED OBESITY; GROWTH-FACTOR 21;
   OXIDATIVE STRESS; INSULIN-RESISTANCE; LIPID-ACCUMULATION;
   ADIPOSE-TISSUE; MITOCHONDRIAL-FUNCTION; MOLECULAR-MECHANISMS; NRF2
   DEFICIENCY
AB Nuclear factor erythroid 2 related factor 2 (Nrf2) is a key regulator of antioxidant signaling that may prevent the development of metabolic syndrome and related cardiovascular diseases. However, emerging evidence shows that lack of Nrf2 could ameliorate insulin resistance, adipogenesis and adipocyte differentiation. Consistent with this, overexpression of Nrf2 gene could also cause insulin resistance under certain conditions. Furthermore, an increasing number of studies indicate that redox balance can be a critical element that contributes to the contradictory effects of Nrf2 on insulin sensitivity and resistance. Reactive oxygen species can promote normal insulin-mediated signal transduction under physiological conditions but also induce insulin resistance under certain pathological conditions. Therefore, the contradictory effects of Nrf2 on insulin signaling pathways may be related to its regulation of redox homeostasis. This review attempts to summarize the latest developments in our understanding of the mechanisms of Nrf2-mediated signaling and its role in the modulation of metabolic homeostasis.
C1 [Zhang, Zhiguo; Zhou, Shanshan; Jiang, Xin; Wang, Yue-Hui; Wang, Yong-Gang; Zheng, Yang] Jilin Univ, Hosp 1, Dept Cardiovasc Disorders, Changchun 130021, Peoples R China.
   [Zhang, Zhiguo; Zhou, Shanshan; Jiang, Xin; Wang, Yue-Hui; Wang, Yong-Gang; Zheng, Yang] Jilin Univ, Hosp 1, Dept Gerontol, Changchun 130021, Peoples R China.
   [Zhang, Zhiguo; Zhou, Shanshan; Jiang, Xin; Wang, Yue-Hui; Wang, Yong-Gang; Zheng, Yang] Jilin Univ, Hosp 1, Dept Radiat Oncol, Changchun 130021, Peoples R China.
   [Zhang, Zhiguo; Zhou, Shanshan; Jiang, Xin; Li, Fengsheng; Wang, Yong-Gang; Cai, Lu] Univ Louisville, Dept Pediat, Kosair Children Hosp Res Inst, Louisville, KY 40202 USA.
   [Li, Fengsheng] Second Artillery Gen Hosp, Beijing 100088, Peoples R China.
C3 Jilin University; Jilin University; Jilin University; University of
   Louisville
RP Zheng, Y (corresponding author), Jilin Univ, Hosp 1, Dept Cardiovasc Disorders, Changchun 130021, Peoples R China.
EM zhengyang@jlu.edu.cn; l0cai001@louisville.edu
RI Cai, Lu/AAG-9920-2019; Jiang, Xin/AHA-9454-2022
OI Jiang, Xin/0000-0002-4613-7438
FU National Natural Science Foundation of China [81370318, 81270293,
   81400281]; American Diabetes Association [1-11-BA-17, 7-14-BS-18]
FX Cited studies from the authors' laboratories were supported in part by
   the grants from the National Natural Science Foundation of China (No.
   81370318, to ZY; No. 81270293, to YHW; No. 81400281, to S.Z) and the
   American Diabetes Association (1-11-BA-17 & 7-14-BS-18, to LC).
CR Aleksunes LM, 2010, J PHARMACOL EXP THER, V333, P140, DOI 10.1124/jpet.109.162271
   Anderson EJ, 2009, J CLIN INVEST, V119, P573, DOI 10.1172/JCI37048
   Bahadoran Z, 2013, J MED FOOD, V16, P375, DOI 10.1089/jmf.2012.2559
   Barazzoni R, 2012, DIABETOLOGIA, V55, P773, DOI 10.1007/s00125-011-2396-x
   Bjelakovic G, 2007, JAMA-J AM MED ASSOC, V297, P842, DOI 10.1001/jama.297.8.842
   Bocci V, 2014, DIABETES METAB SYND, V8, P57, DOI 10.1016/j.dsx.2013.10.004
   Bonnard C, 2008, J CLIN INVEST, V118, P789, DOI 10.1172/JCI32601
   Chang YC, 2013, EMBO MOL MED, V5, P1165, DOI 10.1002/emmm.201302679
   Chartoumpekis DV, 2011, DIABETES, V60, P2465, DOI 10.2337/db11-0112
   Chen TM, 2013, INT J MOL SCI, V14, P2684, DOI 10.3390/ijms14022684
   Cheng ZY, 2009, NAT MED, V15, P1307, DOI 10.1038/nm.2049
   Choi KM, 2014, J NUTR BIOCHEM, V25, P201, DOI 10.1016/j.jnutbio.2013.10.007
   Chorley BN, 2012, NUCLEIC ACIDS RES, V40, P7416, DOI 10.1093/nar/gks409
   Collins AR, 2012, ARTERIOSCL THROM VAS, V32, P2839, DOI 10.1161/ATVBAHA.112.300345
   D'Apolito M, 2010, J CLIN INVEST, V120, P203, DOI 10.1172/JCI37672
   de Champlain J, 2004, CLIN EXP HYPERTENS, V26, P593, DOI 10.1081/CEH-200031904
   de Haan JB, 2011, DIABETES, V60, P2683, DOI 10.2337/db11-1072
   Finkelstein EA, 2012, AM J PREV MED, V42, P563, DOI 10.1016/j.amepre.2011.10.026
   Gaikwad A, 2001, J BIOL CHEM, V276, P22559, DOI 10.1074/jbc.M101053200
   Gao S, 2013, FOOD CHEM TOXICOL, V59, P739, DOI 10.1016/j.fct.2013.07.032
   Gliemann L, 2013, J PHYSIOL-LONDON, V591, P5047, DOI 10.1113/jphysiol.2013.258061
   Go AS, 2013, CIRCULATION, V127, pE6, DOI 10.1161/CIR.0b013e31828124ad
   Gómez-Guzmán M, 2012, FREE RADICAL BIO MED, V52, P70, DOI 10.1016/j.freeradbiomed.2011.09.015
   Grossman E, 2008, DIABETES CARE, V31, pS185, DOI 10.2337/dc08-s246
   Guo SD, 2014, J ENDOCRINOL, V220, pT1, DOI 10.1530/JOE-13-0327
   Han S, 2013, CELL BIOL TOXICOL, V29, P75, DOI 10.1007/s10565-013-9239-0
   He HJ, 2012, WORLD J DIABETES, V3, P94, DOI 10.4239/wjd.v3.i5.94
   Hoehn KL, 2009, P NATL ACAD SCI USA, V106, P17787, DOI 10.1073/pnas.0902380106
   Hou YY, 2012, FREE RADICAL BIO MED, V52, P462, DOI 10.1016/j.freeradbiomed.2011.10.453
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Huang JS, 2010, AM J PHYSIOL-GASTR L, V299, pG1211, DOI 10.1152/ajpgi.00322.2010
   Huang X, 2012, J FINANC SERV RES, V42, P55, DOI 10.1007/s10693-011-0117-8
   Ishii T, 2002, METHOD ENZYMOL, V348, P182, DOI 10.1016/S0076-6879(02)48637-5
   Jin SH, 2013, TOXICOL APPL PHARM, V271, P95, DOI 10.1016/j.taap.2013.04.023
   Jung UJ, 2014, INT J MOL SCI, V15, P6184, DOI 10.3390/ijms15046184
   Kaneto H, 2001, J BIOL CHEM, V276, P31099, DOI 10.1074/jbc.M104115200
   Kang OH, 2013, EUR REV MED PHARMACO, V17, P2578
   Kay HY, 2011, ANTIOXID REDOX SIGN, V15, P2135, DOI 10.1089/ars.2010.3834
   Kendig EL, 2011, TOXICOL APPL PHARM, V257, P338, DOI 10.1016/j.taap.2011.09.017
   Kim TH, 2013, BRIT J PHARMACOL, V168, P1647, DOI 10.1111/bph.12057
   Kitteringham NR, 2010, J PROTEOMICS, V73, P1612, DOI 10.1016/j.jprot.2010.03.018
   Kliewer SA, 2010, AM J CLIN NUTR, V91, p254S, DOI 10.3945/ajcn.2009.28449B
   Kobayashi M, 2006, ADV ENZYME REGUL, V46, P113, DOI 10.1016/j.advenzreg.2006.01.007
   Lee BH, 2012, FREE RADICAL BIO MED, V53, P2008, DOI 10.1016/j.freeradbiomed.2012.09.025
   Lee HY, 2010, CELL METAB, V12, P668, DOI 10.1016/j.cmet.2010.11.004
   Li HT, 2013, FRONT MED-PRC, V7, P25, DOI 10.1007/s11684-013-0244-8
   Li JQ, 2011, CARDIOVASC RES, V90, P315, DOI 10.1093/cvr/cvr010
   Li Y, 2012, INT J OBESITY, V36, P1503, DOI 10.1038/ijo.2011.279
   Lin ZF, 2013, CELL METAB, V17, P779, DOI 10.1016/j.cmet.2013.04.005
   Loh K, 2009, CELL METAB, V10, P260, DOI 10.1016/j.cmet.2009.08.009
   Maddux BA, 2001, DIABETES, V50, P404, DOI 10.2337/diabetes.50.2.404
   Mahadev K, 2004, MOL CELL BIOL, V24, P1844, DOI 10.1128/MCB.24.5.1844-1854.2004
   McClung JP, 2004, P NATL ACAD SCI USA, V101, P8852, DOI 10.1073/pnas.0308096101
   McMahon M, 2003, J BIOL CHEM, V278, P21592, DOI 10.1074/jbc.M300931200
   Meher AK, 2012, FREE RADICAL BIO MED, V52, P1708, DOI 10.1016/j.freeradbiomed.2012.02.022
   Merry TL, 2014, ANTIOXID REDOX SIGN, V20, P2114, DOI 10.1089/ars.2013.5428
   More VR, 2013, FREE RADICAL BIO MED, V61, P85, DOI 10.1016/j.freeradbiomed.2013.03.007
   Morino K, 2006, DIABETES, V55, pS9, DOI 10.2337/db06-S002
   Otto TC, 2005, CRIT REV BIOCHEM MOL, V40, P229, DOI 10.1080/10409230591008189
   Padmanabhan B, 2006, MOL CELL, V21, P689, DOI 10.1016/j.molcel.2006.01.013
   Pi JB, 2010, J BIOL CHEM, V285, P9292, DOI 10.1074/jbc.M109.093955
   Pischon T, 2008, NEW ENGL J MED, V359, P2105, DOI 10.1056/NEJMoa0801891
   Renehan AG, 2008, LANCET, V371, P569, DOI 10.1016/S0140-6736(08)60269-X
   Ristow M, 2009, P NATL ACAD SCI USA, V106, P8665, DOI 10.1073/pnas.0903485106
   Rosen ED, 2005, PROSTAG LEUKOTR ESS, V73, P31, DOI 10.1016/j.plefa.2005.04.004
   Schneider KS, 2013, ADV NUTR, V4, P62, DOI 10.3945/an.112.003103
   Shin S, 2007, MOL CELL BIOL, V27, P7188, DOI 10.1128/MCB.00915-07
   Shin S, 2009, EUR J PHARMACOL, V620, P138, DOI 10.1016/j.ejphar.2009.08.022
   Song MY, 2009, TOXICOL APPL PHARM, V235, P57, DOI 10.1016/j.taap.2008.11.007
   Straczkowski M, 2013, INT J OBESITY, V37, P1386, DOI 10.1038/ijo.2013.10
   Swinburn BA, 2011, LANCET, V378, P804, DOI 10.1016/S0140-6736(11)60813-1
   Taguchi K, 2011, GENES CELLS, V16, P123, DOI 10.1111/j.1365-2443.2010.01473.x
   Tanaka Y, 2008, J PHARMACOL EXP THER, V325, P655, DOI 10.1124/jpet.107.135822
   Tirosh A, 1999, J BIOL CHEM, V274, P10595, DOI 10.1074/jbc.274.15.10595
   Uruno A, 2013, MOL CELL BIOL, V33, P2996, DOI 10.1128/MCB.00225-13
   Veal EA, 2007, MOL CELL, V26, P1, DOI 10.1016/j.molcel.2007.03.016
   Vigouroux C, 2011, INT J BIOCHEM CELL B, V43, P862, DOI 10.1016/j.biocel.2011.03.002
   Virtue S, 2010, BBA-MOL CELL BIOL L, V1801, P338, DOI 10.1016/j.bbalip.2009.12.006
   Wakabayashi N, 2004, P NATL ACAD SCI USA, V101, P2040, DOI 10.1073/pnas.0307301101
   Watson JD, 2014, LANCET, V383, P841, DOI 10.1016/S0140-6736(13)62365-X
   Wu KC, 2011, TOXICOL SCI, V123, P590, DOI 10.1093/toxsci/kfr183
   Xu JL, 2012, DIABETES, V61, P3208, DOI 10.2337/db11-1716
   Xue P, 2013, DIABETES, V62, P845, DOI 10.2337/db12-0584
   Yagishita Y, 2014, DIABETES, V63, P605, DOI 10.2337/db13-0909
   Yates MS, 2009, CARCINOGENESIS, V30, P1024, DOI 10.1093/carcin/bgp100
   Yoon JC, 2001, NATURE, V413, P131, DOI 10.1038/35093050
   Yu Z, 2011, DIABETOLOGIA, V54, P922, DOI 10.1007/s00125-010-2001-8
   Zhai L, 2011, MOL ENDOCRINOL, V25, P492, DOI 10.1210/me.2010-0224
   Zhang W, 2013, GENE DEV, V27, P441, DOI 10.1101/gad.201731.112
   Zhang YKJ, 2012, TOXICOL APPL PHARM, V264, P305, DOI 10.1016/j.taap.2012.09.014
   Zhang YKJ, 2010, TOXICOL APPL PHARM, V245, P326, DOI 10.1016/j.taap.2010.03.016
NR 91
TC 93
Z9 101
U1 1
U2 39
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1389-9155
EI 1573-2606
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD MAR
PY 2015
VL 16
IS 1
BP 35
EP 45
DI 10.1007/s11154-014-9305-9
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CC6RD
UT WOS:000350493800004
PM 25540093
DA 2025-06-11
ER

PT J
AU Afrin, S
   Gasparrini, M
   Forbes-Hernandez, TY
   Reboredo-Rodriguez, P
   Mezzetti, B
   Varela-López, A
   Giampieri, F
   Battino, M
AF Afrin, Sadia
   Gasparrini, Massimiliano
   Forbes-Hernandez, Tamara Y.
   Reboredo-Rodriguez, Patricia
   Mezzetti, Bruno
   Varela-Lopez, Alfonso
   Giampieri, Francesca
   Battino, Maurizio
TI Promising Health Benefits of the Strawberry: A Focus on Clinical Studies
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Review
DE strawberry; phenolic compounds; anti-inflammation; cardioprotection;
   antimetabolic syndrome; antiobesity; antidiabetes; anticancer;
   neuroprotection
ID FRAGARIA-X-ANANASSA; TOTAL ANTIOXIDANT CAPACITY; C-REACTIVE PROTEIN;
   METABOLIC SYNDROME; PHENOLIC-COMPOUNDS; BIOACTIVE COMPOUNDS; VEGETABLE
   INTAKE; CARDIOVASCULAR-DISEASE; NUTRITIONAL QUALITY; DIETARY PATTERNS
AB The potential health benefits associated with dietary intake of fruits have attracted increasing interest. Among berries, the strawberry is a rich source of several nutritive and non-nutritive bioactive compounds, which are implicated in various health-promoting and disease preventive effects. A plethora of studies have examined the benefits of strawberry consumption, such as prevention of inflammation disorders and oxidative stress; reduction of obesity related disorders and heart disease risk, and protection against various types of cancer. This review provides an overview of their nutritional and non-nutritional bioactive compounds and which factors affect their content in strawberries. In addition, the bioavailability and metabolism of major strawberry phytochemicals as well as their actions in combating many pathologies, including cancer, metabolic syndrome, cardiovascular disease, obesity, diabetes, neurodegeneration, along with microbial pathogenesis have been reviewed, with a particular attention to human studies.
C1 [Afrin, Sadia; Gasparrini, Massimiliano; Forbes-Hernandez, Tamara Y.; Reboredo-Rodriguez, Patricia; Giampieri, Francesca; Battino, Maurizio] Univ Politecn Marche, Fac Med, Dipartimento Sci Clin Specialist & Odontostomatol, Sez Biochim, I-60131 Ancona, Italy.
   [Forbes-Hernandez, Tamara Y.] Univ Int Iberoamer UNINI, Area Nutr & Salud, Campeche 24040, Mexico.
   [Reboredo-Rodriguez, Patricia] Univ Vigo, Fac Food Sci & Technol, Analyt & Food Chem Dept, E-32004 Orense, Spain.
   [Mezzetti, Bruno] Univ Politecn Marche, Dipartirnento Sci Agr Alimentari & Ambientali, Via Ranieri 65, I-60131 Ancona, Italy.
   [Varela-Lopez, Alfonso] Univ Granada, Biomed Res Ctr, Inst Nutr & Food Technol Jose Mataix, Dept Physiol, E-18071 Granada, Spain.
   [Battino, Maurizio] Univ Europea Atlantico UEA, Ctr Nutr & Hlth, Santander 39011, Spain.
C3 Marche Polytechnic University; Universidade de Vigo; Marche Polytechnic
   University; University of Granada
RP Giampieri, F; Battino, M (corresponding author), Univ Politecn Marche, Fac Med, Dipartimento Sci Clin Specialist & Odontostomatol, Sez Biochim, I-60131 Ancona, Italy.; Battino, M (corresponding author), Univ Europea Atlantico UEA, Ctr Nutr & Hlth, Santander 39011, Spain.
EM f.giampieri@univpm.it; m.a.battino@univpm.it
RI Reboredo-Rodríguez, Patricia/AAH-2388-2019; Mezzetti,
   Bruno/AAB-8500-2019; Battino, Maurizio/E-6103-2012; Afrin,
   Sadia/AAQ-5030-2020; Varela-Lopez, Alfonso/F-8055-2016; Giampieri,
   Francesca/I-1911-2015; Forbes Hernandez, Tamara/AAB-1872-2021
OI Afrin, Sadia/0000-0001-5063-9900; Varela-Lopez,
   Alfonso/0000-0002-0504-5086; Mezzetti, Bruno/0000-0001-9307-812X;
   Giampieri, Francesca/0000-0002-8151-9132; Forbes Hernandez,
   Tamara/0000-0001-7021-9276; Reboredo Rodriguez,
   Patricia/0000-0001-8440-6347
FU Fondazione Umberto Veronesi Fellowship
FX Dr. F. Giampieri was supported by a Fondazione Umberto Veronesi
   Fellowship.
CR Aaby K, 2007, J AGR FOOD CHEM, V55, P4395, DOI 10.1021/jf0702592
   Aaby K, 2012, FOOD CHEM, V132, P86, DOI 10.1016/j.foodchem.2011.10.037
   Aballay LR, 2013, NUTR REV, V71, P168, DOI 10.1111/j.1753-4887.2012.00533.x
   Afrin S, 2016, MOLECULES, V21, DOI 10.3390/molecules21020169
   Alvarez-Suarez JM, 2014, J BERRY RES, V4, P1, DOI 10.3233/JBR-140068
   Alvarez-Suarez JM, 2014, J NUTR BIOCHEM, V25, P289, DOI 10.1016/j.jnutbio.2013.11.002
   Alvarez-Suarez JM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025878
   Alvarez-Suarez JM, 2010, FOOD CHEM TOXICOL, V48, P2490, DOI 10.1016/j.fct.2010.06.021
   Amani R, 2014, WORLD J DIABETES, V5, P962, DOI 10.4239/wjd.v5.i6.962
   AMES BN, 1993, P NATL ACAD SCI USA, V90, P7915, DOI 10.1073/pnas.90.17.7915
   Anderson AL, 2012, EUR J CLIN NUTR, V66, P18, DOI 10.1038/ejcn.2011.162
   [Anonymous], CRIT REV FOOD SCI NU
   [Anonymous], 2015, USDA NAT NUTR DAT ST
   [Anonymous], CRIT REV FOOD SCI NU
   Anthony JP, 2007, METHODS, V42, P339, DOI 10.1016/j.ymeth.2007.02.011
   Anthony JP, 2011, PARASITOLOGY, V138, P1110, DOI 10.1017/S0031182011000825
   Ayala-Zavala JF, 2004, LEBENSM-WISS TECHNOL, V37, P687, DOI 10.1016/j.lwt.2004.03.002
   Azzini E, 2010, J BERRY RES, V1, P81, DOI 10.3233/BR-2010-009
   Azzini E, 2010, BRIT J NUTR, V104, P1165, DOI 10.1017/S000711451000187X
   Basu A, 2014, J NUTR, V144, P830, DOI 10.3945/jn.113.188169
   Basu A, 2014, CRIT REV FOOD SCI, V54, P790, DOI 10.1080/10408398.2011.608174
   Basu A, 2012, J AGR FOOD CHEM, V60, P5687, DOI 10.1021/jf203488k
   Basu A, 2010, NUTR RES, V30, P462, DOI 10.1016/j.nutres.2010.06.016
   Basu A, 2010, NUTR REV, V68, P168, DOI 10.1111/j.1753-4887.2010.00273.x
   Basu A, 2009, NUTR J, V8, DOI 10.1186/1475-2891-8-43
   Battino M, 2009, NUTR REV, V67, pS145, DOI 10.1111/j.1753-4887.2009.00178.x
   Baxter AJ, 2006, ASIA PAC J CLIN NUTR, V15, P134
   Bridle P, 1997, FOOD CHEM, V59, P299, DOI 10.1016/S0308-8146(96)00176-8
   Brown EM, 2014, J AGR FOOD CHEM, V62, P3852, DOI 10.1021/jf4050759
   Buendia B, 2010, J AGR FOOD CHEM, V58, P3916, DOI 10.1021/jf9030597
   Burton-Freeman B, 2010, J AM COLL NUTR, V29, P46, DOI 10.1080/07315724.2010.10719816
   Calder PC, 2011, BRIT J NUTR, V106, pS1, DOI 10.1017/S0007114511005460
   Calder PC, 2009, BRIT J NUTR, V101, P1, DOI 10.1017/S0007114508076228
   Capocasa F, 2008, FOOD CHEM, V111, P872, DOI 10.1016/j.foodchem.2008.04.068
   Carkeet C, 2008, J NUTR, V138, P897, DOI 10.1093/jn/138.5.897
   Espín JC, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/270418
   Carlton PS, 2001, CARCINOGENESIS, V22, P441, DOI 10.1093/carcin/22.3.441
   Cassidy A, 2013, CIRCULATION, V127, P188, DOI 10.1161/CIRCULATIONAHA.112.122408
   Cassidy A, 2011, AM J CLIN NUTR, V93, P338, DOI 10.3945/ajcn.110.006783
   Castro I, 2002, J FOOD SCI, V67, P2132, DOI 10.1111/j.1365-2621.2002.tb09515.x
   Cerdá B, 2005, J AGR FOOD CHEM, V53, P227, DOI 10.1021/jf049144d
   Chen T, 2012, CANCER PREV RES, V5, P41, DOI 10.1158/1940-6207.CAPR-11-0469
   Chung MJ, 2002, CANCER LETT, V182, P1, DOI 10.1016/S0304-3835(02)00076-9
   Cooper AJM, 2015, EUR J CLIN NUTR, V69, P449, DOI 10.1038/ejcn.2014.246
   Cowey S, 2006, AM J PATHOL, V169, P1505, DOI 10.2353/ajpath.2006.051090
   Crecente-Campo J, 2012, J FOOD COMPOS ANAL, V28, P23, DOI 10.1016/j.jfca.2012.07.004
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   de Souza VR, 2014, FOOD CHEM, V156, P362, DOI 10.1016/j.foodchem.2014.01.125
   Del Rio D, 2013, ANTIOXID REDOX SIGN, V18, P1818, DOI 10.1089/ars.2012.4581
   Devore EE, 2012, ANN NEUROL, V72, P135, DOI 10.1002/ana.23594
   Diamanti J, 2014, J AGR FOOD CHEM, V62, P3935, DOI 10.1021/jf405721d
   Diamanti J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046470
   Diamanti J, 2010, J BERRY RES, V1, P103, DOI 10.3233/BR-2010-011
   Edirisinghe I, 2011, BRIT J NUTR, V106, P913, DOI 10.1017/S0007114511001176
   Ellis CL, 2011, J ATHEROSCLER THROMB, V18, P318, DOI 10.5551/jat.6114
   Fang J, 2014, DRUG METAB REV, V46, P508, DOI 10.3109/03602532.2014.978080
   Felgines C, 2003, J NUTR, V133, P1296
   Fowler MJ., 2008, CLIN DIABETES, V26, P77, DOI DOI 10.2337/DIACLIN.26.2.77
   Fredericks CH, 2013, J SCI FOOD AGR, V93, P846, DOI 10.1002/jsfa.5806
   Freedman ND, 2008, INT J CANCER, V122, P2330, DOI 10.1002/ijc.23319
   Freedman ND, 2007, INT J CANCER, V121, P2753, DOI 10.1002/ijc.22993
   Giampieri F, 2015, FOOD FUNCT, V6, P1386, DOI [10.1039/C5FO00147A, 10.1039/c5fo00147a]
   Giampieri F, 2014, FOOD FUNCT, V5, P1939, DOI [10.1039/c4fo00048j, 10.1039/C4FO00048J]
   Giampieri F, 2014, MOLECULES, V19, P7798, DOI 10.3390/molecules19067798
   Giampieri F, 2014, J AGR FOOD CHEM, V62, P3867, DOI 10.1021/jf405455n
   Giampieri F, 2013, NAT PROD RES, V27, P448, DOI 10.1080/14786419.2012.706294
   Giampieri F, 2012, J AGR FOOD CHEM, V60, P2322, DOI 10.1021/jf205065x
   Giampieri F, 2012, NUTRITION, V28, P9, DOI 10.1016/j.nut.2011.08.009
   González-Castejón M, 2011, PHARMACOL RES, V64, P438, DOI 10.1016/j.phrs.2011.07.004
   Gratchev A, 2012, IMMUNOBIOLOGY, V217, P476, DOI 10.1016/j.imbio.2012.01.008
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Gülçin I, 2013, MINI-REV MED CHEM, V13, P408
   Gündüz K, 2014, FOOD CHEM, V155, P298, DOI 10.1016/j.foodchem.2014.01.064
   Häkkinen SH, 2000, FOOD RES INT, V33, P517, DOI 10.1016/S0963-9969(00)00086-7
   Henning SM, 2010, J MED FOOD, V13, P116, DOI 10.1089/jmf.2009.0048
   Hernanz D, 2007, J AGR FOOD CHEM, V55, P1846, DOI 10.1021/jf063189s
   Hollands W, 2008, MOL NUTR FOOD RES, V52, P1097, DOI 10.1002/mnfr.200700372
   Ibero-Baraibar I, 2014, EUR J NUTR, V53, P201, DOI 10.1007/s00394-013-0517-7
   Jemal A, 2007, CA-CANCER J CLIN, V57, P43, DOI 10.3322/canjclin.57.1.43
   Jin P, 2011, FOOD CHEM, V124, P262, DOI 10.1016/j.foodchem.2010.06.029
   Joseph JA, 1999, J NEUROSCI, V19, P8114
   Joseph SV, 2014, J AGR FOOD CHEM, V62, P3886, DOI 10.1021/jf4044056
   Kadivec M, 2013, J AGR FOOD CHEM, V61, P9220, DOI 10.1021/jf4035767
   Khalifa HO, 2015, PHYTOTHER RES, V29, P1791, DOI 10.1002/ptr.5436
   Kim SK, 2015, FOOD CHEM, V184, P196, DOI 10.1016/j.foodchem.2015.03.060
   Kim YJ, 2015, J KOREAN SOC APPL BI, V58, P587, DOI 10.1007/s13765-015-0085-z
   Klopotek Y, 2005, J AGR FOOD CHEM, V53, P5640, DOI 10.1021/jf047947v
   Kurotobi T, 2010, J NUTR SCI VITAMINOL, V56, P198, DOI 10.3177/jnsv.56.198
   da Silva FL, 2007, LWT-FOOD SCI TECHNOL, V40, P374, DOI 10.1016/j.lwt.2005.09.018
   Lopes-da-Silva F, 2002, EUR FOOD RES TECHNOL, V214, P248, DOI 10.1007/s00217-001-0434-5
   Manzano S, 2010, MOL NUTR FOOD RES, V54, P1773, DOI 10.1002/mnfr.201000019
   Martin A, 2000, J GERONTOL A-BIOL, V55, pB144, DOI 10.1093/gerona/55.3.B144
   Mazzoni L, 2016, J SCI FOOD AGR, V96, P365, DOI 10.1002/jsfa.7216
   McDougall GJ, 2005, J AGR FOOD CHEM, V53, P2760, DOI 10.1021/jf0489926
   Mullen W, 2008, J AGR FOOD CHEM, V56, P713, DOI 10.1021/jf072000p
   Mullenix PS, 2005, ANN VASC SURG, V19, P130, DOI 10.1007/s10016-004-0153-z
   Muraki I, 2013, BMJ-BRIT MED J, V347, DOI 10.1136/bmj.f5001
   Mursu J, 2014, AM J CLIN NUTR, V99, P328, DOI 10.3945/ajcn.113.069641
   Nanri H, 2011, J EPIDEMIOL, V21, P122, DOI 10.2188/jea.JE20100110
   Nile SH, 2014, NUTRITION, V30, P134, DOI 10.1016/j.nut.2013.04.007
   Nohynek LJ, 2006, NUTR CANCER, V54, P18, DOI 10.1207/s15327914nc5401_4
   Norat T, 2014, CANCER TREAT RES, V159, P35, DOI 10.1007/978-3-642-38007-5_3
   Olsson ME, 2004, J AGR FOOD CHEM, V52, P2490, DOI 10.1021/jf030461e
   Parelman MA, 2012, BRIT J NUTR, V108, P1789, DOI 10.1017/S0007114512000037
   Pem D, 2015, IRAN J PUBLIC HEALTH, V44, P1309
   Pineli LDD, 2011, J FOOD COMPOS ANAL, V24, P11, DOI 10.1016/j.jfca.2010.05.004
   Pistollato F, 2014, TRENDS FOOD SCI TECH, V40, P62, DOI 10.1016/j.tifs.2014.07.012
   Plumed-Ferrer C, 2013, INT J FOOD MICROBIOL, V164, P99, DOI 10.1016/j.ijfoodmicro.2013.04.001
   Prymont-Przyminska A, 2014, J CLIN BIOCHEM NUTR, V55, P48, DOI 10.3164/jcbn.13-93
   Puupponen-Pimiä R, 2005, APPL MICROBIOL BIOT, V67, P8, DOI 10.1007/s00253-004-1817-x
   Reganold JP, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012346
   Ridker PM, 2003, CIRCULATION, V107, P363, DOI 10.1161/01.CIR.0000053730.47739.3C
   Romandini S, 2013, J BERRY RES, V3, P169, DOI 10.3233/JBR-130055
   Rosenberg PB, 2006, INT REV PSYCHIATR, V17, P503, DOI 10.1080/02646830500382037
   Roy M, 2008, LIFE SCI, V82, P1102, DOI 10.1016/j.lfs.2008.03.011
   Russell WR, 2009, MOL NUTR FOOD RES, V53, pS85, DOI 10.1002/mnfr.200800302
   Sabaté J, 2015, BRIT J NUTR, V113, pS136, DOI 10.1017/S0007114514004139
   Scalzo J, 2005, NUTRITION, V21, P207, DOI 10.1016/j.nut.2004.03.025
   Shaw JE, 2010, DIABETES RES CLIN PR, V87, P4, DOI 10.1016/j.diabres.2009.10.007
   Smith SC, 2012, EUR HEART J, V33, P2910, DOI 10.1093/eurheartj/ehs313
   Stoner GD, 2007, SEMIN CANCER BIOL, V17, P403, DOI 10.1016/j.semcancer.2007.05.001
   Törrönen R, 2013, J NUTR, V143, P430, DOI 10.3945/jn.112.169771
   Törrönen R, 2012, BRIT J NUTR, V107, P1445, DOI 10.1017/S0007114511004557
   Truchado P, 2012, J AGR FOOD CHEM, V60, P5749, DOI 10.1021/jf203641r
   Tulipani S, 2009, ACTA HORTIC, V842, P867, DOI 10.17660/ActaHortic.2009.842.191
   Tulipani S, 2008, J AGR FOOD CHEM, V56, P696, DOI 10.1021/jf0719959
   Tulipani S, 2014, FOOD CHEM, V156, P87, DOI 10.1016/j.foodchem.2014.01.098
   Tulipani S, 2011, FOOD CHEM, V128, P180, DOI 10.1016/j.foodchem.2011.03.025
   Tulipani S, 2011, FOOD CHEM, V124, P906, DOI 10.1016/j.foodchem.2010.07.018
   Tulipani S, 2009, PUBLIC HEALTH NUTR, V12, P1656, DOI 10.1017/S1368980009990516
   Wang SY, 2009, J AGR FOOD CHEM, V57, P9651, DOI 10.1021/jf9020575
   Wang SY, 2005, J AGR FOOD CHEM, V53, P4187, DOI 10.1021/jf0478049
   Webster D, 2008, J ETHNOPHARMACOL, V115, P140, DOI 10.1016/j.jep.2007.09.014
   Yang ZF, 2014, FITOTERAPIA, V93, P47, DOI 10.1016/j.fitote.2013.12.011
   Youdim KA, 2001, FREE RADICAL BIO MED, V30, P583, DOI 10.1016/S0891-5849(00)00510-4
   Zhang YJ, 2008, J AGR FOOD CHEM, V56, P670, DOI 10.1021/jf071989c
   Zheng YH, 2007, LWT-FOOD SCI TECHNOL, V40, P49, DOI 10.1016/j.lwt.2005.08.013
   Zunino SJ, 2013, BRIT J NUTR, V110, P2011, DOI 10.1017/S0007114513000937
   Zunino SJ, 2012, BRIT J NUTR, V108, P900, DOI 10.1017/S0007114511006027
NR 139
TC 211
Z9 230
U1 8
U2 222
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD JUN 8
PY 2016
VL 64
IS 22
BP 4435
EP 4449
DI 10.1021/acs.jafc.6b00857
PG 15
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA DO2XB
UT WOS:000377643200001
PM 27172913
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Gupta, V
   Mah, XJ
   Garcia, MC
   Antonypillai, C
   van der Poorten, D
AF Gupta, Vikas
   Mah, Xian-Jun
   Garcia, Maria Carmela
   Antonypillai, Christina
   van der Poorten, David
TI Oily fish, coffee and walnuts: Dietary treatment for nonalcoholic fatty
   liver disease
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Diet;
   Coffee; Tea; Olive oil; Nuts; Walnuts; Fish; Fish oils; Red wine
ID RED WINE POLYPHENOLS; CORONARY-HEART-DISEASE; OLIVE OIL; NUT
   CONSUMPTION; CARDIOVASCULAR-DISEASE; GREEN TEA; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; RISK-FACTORS
AB Rates of non-alcoholic fatty liver disease (NAFLD) are increasing worldwide in tandem with the metabolic syndrome, with the progressive form of disease, nonalcoholic steatohepatitis (NASH) likely to become the most common cause of end stage liver disease in the not too distant future. Lifestyle modification and weight loss remain the main focus of management in NAFLD and NASH, however, there has been growing interest in the benefit of specific foods and dietary components on disease progression, with some foods showing protective properties. This article provides an overview of the foods that show the most promise and their potential benefits in NAFLD/NASH, specifically; oily fish/fish oil, coffee, nuts, tea, red wine, avocado and olive oil. Furthermore, it summarises results from animal and human trials and highlights potential areas for future research.
C1 [Gupta, Vikas; Mah, Xian-Jun; Garcia, Maria Carmela; Antonypillai, Christina; van der Poorten, David] Univ Sydney, Westmead Hosp, Dept Gastroenterol & Hepatol, Div Med, Westmead, NSW 2145, Australia.
C3 NSW Health; Westmead Hospital; University of Sydney
RP van der Poorten, D (corresponding author), Univ Sydney, Westmead Hosp, Dept Gastroenterol & Hepatol, Div Med, Hawkesbury Rd Westmead, Westmead, NSW 2145, Australia.
EM david.vanderpoorten@sydney.edu.au
CR Abenavoli L, 2014, WORLD J GASTROENTERO, V20, P16831, DOI 10.3748/wjg.v20.i45.16831
   Agouni A, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005557
   Al-Awwadi NA, 2004, J AGR FOOD CHEM, V52, P5593, DOI 10.1021/jf049295g
   Al-Dosari MS, 2011, AFR J PHARM PHARMACO, V5, P1475
   Albert CM, 2002, ARCH INTERN MED, V162, P1382, DOI 10.1001/archinte.162.12.1382
   Anty R, 2012, J HEPATOL, V57, P1090, DOI 10.1016/j.jhep.2012.07.014
   Argo CK, 2015, J HEPATOL, V62, P190, DOI 10.1016/j.jhep.2014.08.036
   Auger C, 2002, J NUTR, V132, P1207, DOI 10.1093/jn/132.6.1207
   Bambha K, 2014, LIVER INT, V34, P1250, DOI 10.1111/liv.12379
   BANG HO, 1976, ACTA MED SCAND, V200, P69
   Bao Y, 2013, NEW ENGL J MED, V369, P2001, DOI 10.1056/NEJMoa1307352
   Barrera F, 2014, CLIN LIVER DIS, V18, P91, DOI 10.1016/j.cld.2013.09.009
   Barrera F, 2012, HEPATOLOGY, V56, p889A
   Bes-Rastrollo M, 2007, OBESITY, V15, P107, DOI 10.1038/oby.2007.507
   Birerdinc A, 2012, ALIMENT PHARM THER, V35, P76, DOI 10.1111/j.1365-2036.2011.04916.x
   Blomhoff R, 2006, BRIT J NUTR, V96, pS52, DOI 10.1017/BJN20061864
   Borriello A, 2014, CANCER TREAT RES, V159, P167, DOI 10.1007/978-3-642-38007-5_10
   Bouzianas DG, 2013, NUTR REV, V71, P753, DOI 10.1111/nure.12073
   Bozzetto L, 2012, DIABETES CARE, V35, P1429, DOI 10.2337/dc12-0033
   Browning LM, 2014, J NUTR, V144, P667, DOI 10.3945/jn.113.186346
   Buckland G, 2012, AM J CLIN NUTR, V96, P142, DOI 10.3945/ajcn.111.024216
   Calpe-Berdiel L, 2009, ATHEROSCLEROSIS, V203, P18, DOI 10.1016/j.atherosclerosis.2008.06.026
   Carvajal-Zarrabal O, 2014, DIS MARKERS, V2014, DOI 10.1155/2014/386425
   Carvalhana S, 2012, CURR OPIN CLIN NUTR, V15, P468, DOI 10.1097/MCO.0b013e3283566614
   Casas-Agustench P, 2011, NUTR METAB CARDIOVAS, V21, P126, DOI 10.1016/j.numecd.2009.08.005
   Casas-Agustench P, 2011, PUBLIC HEALTH NUTR, V14, P2296, DOI 10.1017/S1368980011002540
   Chen CYO, 2008, ASIA PAC J CLIN NUTR, V17, P329
   Chen SH, 2014, J GASTROEN HEPATOL, V29, P435, DOI 10.1111/jgh.12422
   Chiva-Blanch G, 2013, CLIN NUTR, V32, P200, DOI 10.1016/j.clnu.2012.08.022
   Cooper R, 2005, J ALTERN COMPLEM MED, V11, P521, DOI 10.1089/acm.2005.11.521
   Corrao G, 2001, ANN EPIDEMIOL, V11, P458, DOI 10.1016/S1047-2797(01)00223-X
   Covas MI, 2007, PHARMACOL RES, V55, P175, DOI 10.1016/j.phrs.2007.01.010
   Dasarathy S, 2015, J CLIN GASTROENTEROL, V49, P137, DOI 10.1097/MCG.0000000000000099
   De la Cruz JP, 2000, BBA-MOL CELL BIOL L, V1485, P36, DOI 10.1016/S1388-1981(00)00027-5
   Ding HM, 2009, NUTR CANCER, V61, P348, DOI 10.1080/01635580802567158
   Ding M, 2014, CIRCULATION, V129, P643, DOI 10.1161/CIRCULATIONAHA.113.005925
   Ding M, 2014, DIABETES CARE, V37, P569, DOI 10.2337/dc13-1203
   Djoussé L, 2009, CLIN NUTR, V28, P10, DOI 10.1016/j.clnu.2008.08.005
   Dreher ML, 2013, CRIT REV FOOD SCI, V53, P738, DOI 10.1080/10408398.2011.556759
   Pahua-Ramos ME, 2014, PLANT FOOD HUM NUTR, V69, P18, DOI 10.1007/s11130-013-0395-4
   Estruch R, 2013, NEW ENGL J MED, V368, P1279, DOI 10.1056/NEJMoa1200303
   Ferramosca A, 2008, BIOSCI BIOTECH BIOCH, V72, P62, DOI 10.1271/bbb.70369
   FRASER GE, 1992, ARCH INTERN MED, V152, P1416, DOI 10.1001/archinte.152.7.1416
   Freedman ND, 2012, NEW ENGL J MED, V366, P1891, DOI 10.1056/NEJMoa1112010
   Freedman ND, 2011, GASTROENTEROLOGY, V140, P1961, DOI 10.1053/j.gastro.2011.02.061
   Freedman ND, 2009, HEPATOLOGY, V50, P1360, DOI 10.1002/hep.23162
   Fulgoni VL, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-1
   Gallus S, 2002, BRIT J CANCER, V87, P956, DOI 10.1038/sj.bjc.6600582
   Gatselis NK, 2014, CLIN EXP MED, V14, P121, DOI 10.1007/s10238-012-0227-0
   Gebauer SK, 2008, AM J CLIN NUTR, V88, P651, DOI 10.1093/ajcn/88.3.651
   Gelatti U, 2005, J HEPATOL, V42, P528, DOI 10.1016/j.jhep.2004.11.039
   Han JM, 2014, J GASTROEN HEPATOL, V29, P1265, DOI 10.1111/jgh.12520
   Hansen AS, 2005, EUR J CLIN NUTR, V59, P449, DOI 10.1038/sj.ejcn.1602107
   Harris WS, 2007, AM J CLIN NUTR, V86, P1621
   Hoffman R, 2012, MEDITERRANEAN DIET
   Hu FB, 1998, BMJ-BRIT MED J, V317, P1341, DOI 10.1136/bmj.317.7169.1341
   Hu G, 2008, HEPATOLOGY, V48, P129, DOI 10.1002/hep.22320
   Ibarrola-Jurado N, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057367
   IMAI K, 1995, BRIT MED J, V310, P693, DOI 10.1136/bmj.310.6981.693
   Jiang R, 2002, JAMA-J AM MED ASSOC, V288, P2554, DOI 10.1001/jama.288.20.2554
   Guzmán-Rodríguez JJ, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/986273
   Karmakar S, 2011, PHYTOTHER RES, V25, P1073, DOI 10.1002/ptr.3466
   Kasdallah-Grissa A, 2008, NUTR RES, V28, P472, DOI 10.1016/j.nutres.2008.03.014
   Kasdallah-Grissa A, 2007, LIFE SCI, V80, P1033, DOI 10.1016/j.lfs.2006.11.044
   Kawagishi H, 2001, J AGR FOOD CHEM, V49, P2215, DOI 10.1021/jf0015120
   Kechagias S, 2011, ANN MED, V43, P545, DOI 10.3109/07853890.2011.588246
   Kim D, 2013, HEPATOLOGY, V57, P1357, DOI 10.1002/hep.26156
   King JG, 2008, J NUTR, V138, p1736S, DOI 10.1093/jn/138.9.1736S
   Klatsky A L, 1993, Ann Epidemiol, V3, P375, DOI 10.1016/1047-2797(93)90064-B
   KLATSKY AL, 1992, AM J EPIDEMIOL, V136, P1248, DOI 10.1093/oxfordjournals.aje.a116433
   Klatsky AL, 2006, ARCH INTERN MED, V166, P1190, DOI 10.1001/archinte.166.11.1190
   Kornsteiner M, 2006, FOOD CHEM, V98, P381, DOI 10.1016/j.foodchem.2005.07.033
   Kuriyama S, 2006, JAMA-J AM MED ASSOC, V296, P1255, DOI 10.1001/jama.296.10.1255
   La Vecchia C, 1998, EUR J CANCER PREV, V7, P315
   Lee JH, 2013, PEDIATR GASTROENTERO, V16, P153, DOI 10.5223/pghn.2013.16.3.153
   Li TY, 2009, J NUTR, V139, P1333, DOI 10.3945/jn.108.103622
   Lovejoy JC, 2002, AM J CLIN NUTR, V76, P1000, DOI 10.1093/ajcn/76.5.1000
   Machado MV, 2014, WORLD J GASTROENTERO, V20, P12956, DOI 10.3748/wjg.v20.i36.12956
   Maguire LS, 2004, INT J FOOD SCI NUTR, V55, P171, DOI 10.1080/09637480410001725175
   Mahaffey KR, 2011, NUTR REV, V69, P493, DOI 10.1111/j.1753-4887.2011.00415.x
   Masterjohn C, 2012, NUTR REV, V70, P41, DOI 10.1111/j.1753-4887.2011.00440.x
   Masterton GS, 2010, ALIMENT PHARM THER, V31, P679, DOI 10.1111/j.1365-2036.2010.04230.x
   Mazzanti G, 2009, EUR J CLIN PHARMACOL, V65, P331, DOI 10.1007/s00228-008-0610-7
   Meyer BJ, 2011, PROSTAG LEUKOTR ESS, V85, P275, DOI 10.1016/j.plefa.2011.04.010
   Mohamed AI, 2002, J NUTR BIOCHEM, V13, P435, DOI 10.1016/S0955-2863(02)00196-1
   Molloy JW, 2012, HEPATOLOGY, V55, P429, DOI 10.1002/hep.24731
   Morton J., 1987, FRUITS WARM CLIMATES, P352
   Nakbi A, 2010, NUTR METAB, V7, DOI 10.1186/1743-7075-7-80
   Napoli R, 2005, METABOLISM, V54, P306, DOI 10.1016/j.metabol.2004.09.010
   Naveh E, 2002, J NUTR, V132, P2015, DOI 10.1093/jn/132.7.2015
   Nigam P, 2014, DIABETES TECHNOL THE, V16, P255, DOI 10.1089/dia.2013.0178
   Nobili V, 2013, NUTR METAB CARDIOVAS, V23, P1066, DOI 10.1016/j.numecd.2012.10.010
   Nobili V, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0088005
   Nobili V, 2011, ARCH DIS CHILD, V96, P350, DOI 10.1136/adc.2010.192401
   Nordmann AJ, 2011, AM J MED, V124, P841, DOI 10.1016/j.amjmed.2011.04.024
   O'Neil CE, 2011, J AM COLL NUTR, V30, P502, DOI 10.1080/07315724.2011.10719996
   Pacifico L, 2014, MINI-REV MED CHEM, V14, P791
   Padmanabhan Monika, 2014, J Complement Integr Med, V11, P107, DOI 10.1515/jcim-2013-0053
   Pal S, 2003, J NUTR, V133, P700, DOI 10.1093/jn/133.3.700
   Pan A, 2013, J NUTR, V143, P512, DOI 10.3945/jn.112.172171
   Papanikolaou Yanni, 2014, Nutr J, V13, P31, DOI 10.1186/1475-2891-13-31
   Park HJ, 2012, J NUTR, V142, P57, DOI 10.3945/jn.111.148544
   Park S, 2011, J HEPATOL, V54, P984, DOI 10.1016/j.jhep.2010.08.019
   Parker HM, 2012, J HEPATOL, V56, P944, DOI 10.1016/j.jhep.2011.08.018
   Paschos P, 2009, HIPPOKRATIA, V13, P9
   Pelucchi C, 2011, CURR PHARM DESIGN, V17, P805, DOI 10.2174/138161211795428920
   Rainey C., 1997, Nutrition Today, V32, P157, DOI 10.1097/00017285-199707000-00006
   Roberts RL, 2009, CLIN DERMATOL, V27, P195, DOI 10.1016/j.clindermatol.2008.01.011
   Robinson J., 2006, The Oxford companion to wine, V3rd
   Ronis MJJ, 2012, PHYSIOL GENOMICS, V44, P1073, DOI 10.1152/physiolgenomics.00069.2012
   Ros E, 2004, CIRCULATION, V109, P1609, DOI 10.1161/01.CIR.0000124477.91474.FF
   Ros E, 2010, NUTRIENTS, V2, P652, DOI 10.3390/nu2070652
   Rosenblat G, 2011, ARCH DERMATOL RES, V303, P239, DOI 10.1007/s00403-010-1088-6
   Ruf JC, 2003, DRUG EXP CLIN RES, V29, P173
   Ruhl CE, 2005, GASTROENTEROLOGY, V128, P24, DOI 10.1053/j.gastro.2004.09.075
   Ruhl CE, 2005, GASTROENTEROLOGY, V129, P1928, DOI 10.1053/j.gastro.2005.08.056
   Sabaté J, 2003, AM J CLIN NUTR, V77, P1379, DOI 10.1093/ajcn/77.6.1379
   Sakata R, 2013, INT J MOL MED, V32, P989, DOI 10.3892/ijmm.2013.1503
   Sang LX, 2013, BMC GASTROENTEROL, V13, DOI 10.1186/1471-230X-13-34
   Sanyal AJ, 2014, GASTROENTEROLOGY, V147, P377, DOI 10.1053/j.gastro.2014.04.046
   Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929
   Scorletti E, 2013, ANNU REV NUTR, V33, P231, DOI 10.1146/annurev-nutr-071812-161230
   Scorletti E, 2014, HEPATOLOGY, V60, P1211, DOI 10.1002/hep.27289
   Senault C, 2000, NUTR METAB CARDIOVAS, V10, P63
   Sofi F, 2010, INT J FOOD SCI NUTR, V61, P792, DOI 10.3109/09637486.2010.487480
   Su HC, 2006, AM J PHYSIOL-ENDOC M, V290, pE1339, DOI 10.1152/ajpendo.00487.2005
   Tanaka N, 2008, J CLIN GASTROENTEROL, V42, P413, DOI 10.1097/MCG.0b013e31815591aa
   Tapiero H, 2004, BIOMED PHARMACOTHER, V58, P100, DOI 10.1016/j.biopha.2003.12.006
   Theobald H, 2000, J STUD ALCOHOL, V61, P652, DOI 10.15288/jsa.2000.61.652
   Tomé-Carneiro J, 2013, CURR PHARM DESIGN, V19, P6064, DOI 10.2174/13816128113199990407
   Torres DM, 2013, GASTROENTEROLOGY, V144, P670, DOI 10.1053/j.gastro.2013.02.015
   Torres DM, 2012, CLIN GASTROENTEROL H, V10, P837, DOI 10.1016/j.cgh.2012.03.011
   Unlu NZ, 2005, J NUTR, V135, P431, DOI 10.1093/jn/135.3.431
   van der Poorten D, 2007, HEPATOL INT, V1, P343, DOI 10.1007/s12072-007-9011-8
   Vazquez-Prieto MA, 2011, AM J HYPERTENS, V24, P234, DOI 10.1038/ajh.2010.214
   Vega D., 2010, HIST OLIVE OIL KAUFM
   Wall R, 2010, NUTR REV, V68, P280, DOI 10.1111/j.1753-4887.2010.00287.x
   Weinberg BennettAlan., 2001, The World of Caffeine : The Science and Culture of the World's most Popular Drug
   Wien MA, 2003, INT J OBESITY, V27, P1365, DOI 10.1038/sj.ijo.0802411
   Xiao J, 2014, EUR J NUTR, V53, P187, DOI 10.1007/s00394-013-0516-8
   Yasir Mohammad, 2010, Pharmacogn Rev, V4, P77, DOI 10.4103/0973-7847.65332
   Yesil A, 2013, ALIMENT PHARM THER, V38, P1038, DOI 10.1111/apt.12489
NR 142
TC 33
Z9 36
U1 1
U2 46
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD OCT 7
PY 2015
VL 21
IS 37
BP 10621
EP 10635
DI 10.3748/wjg.v21.i37.10621
PG 15
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA CS5LC
UT WOS:000362118500014
PM 26457022
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Muniyappa, R
   Sowers, JR
AF Muniyappa, Ranganath
   Sowers, James R.
TI Role of insulin resistance in endothelial dysfunction
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Article
DE Nitric oxide; Insulin resistance; Endothelial dysfunction; Metabolic
   syndrome
ID NITRIC-OXIDE SYNTHASE; DEPENDENT DIABETES-MELLITUS;
   POLYCYSTIC-OVARY-SYNDROME; CORONARY-ARTERY-DISEASE; ORAL VITAMIN-C;
   METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; ESSENTIAL-HYPERTENSION;
   OXIDATIVE STRESS; BLOOD-PRESSURE
AB Insulin resistance is frequently associated with endothelial dysfunction and has been proposed to play a major role in cardiovascular diseases. Insulin exerts pro- and anti-atherogenic actions on the vasculature. The balance between nitric oxide (NO)-dependent vasodilator actions and endothelin-1- dependent vasoconstrictor actions of insulin is regulated by phosphatidylinositol 3-kinase-dependent (PI3K) - and mitogen-activated protein kinase (MAPK)-dependent signaling in vascular endothelium, respectively. During insulin-resistant conditions, pathway-specific impairment in PI3K-dependent signaling may cause imbalance between production of NO and secretion of endothelin-1 and lead to endothelial dysfunction. Insulin sensitizers that target pathway-selective impairment in insulin signaling are known to improve endothelial dysfunction. In this review, we discuss the cellular mechanisms in the endothelium underlying vascular actions of insulin, the role of insulin resistance in mediating endothelial dysfunction, and the effect of insulin sensitizers in restoring the balance in pro- and anti-atherogenic actions of insulin.
C1 [Muniyappa, Ranganath] NIDDK, Clin Endocrine Sect, Diabet Endocrinol & Obes Branch, NIH, Bethesda, MD USA.
   [Sowers, James R.] Univ Missouri, Sch Med, Dept Internal Med, Columbia, MO 65212 USA.
   [Sowers, James R.] Univ Missouri, Sch Med, Dept Med Pharmacol & Physiol, Columbia, MO 65212 USA.
   [Sowers, James R.] Harry S Truman Mem Vet Hosp, Columbia, MO 65201 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Diabetes & Digestive & Kidney Diseases (NIDDK); University of Missouri
   System; University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); Harry S. Truman Memorial Veterans'
   Hospital
RP Sowers, JR (corresponding author), Univ Missouri, Sch Med, Dept Internal Med, 1 Hosp Dr, Columbia, MO 65212 USA.
EM sowersj@health.missouri.edu
FU Intramural Research Program of National Institute of Diabetes and
   Digestive and Kidney Diseases, National Institutes of Health (NIH); NIH
   [R01 HL73101-08, R01 HL107910-03]; Veterans Affairs Merit System [0018]
FX This work was supported by the Intramural Research Program of National
   Institute of Diabetes and Digestive and Kidney Diseases, National
   Institutes of Health (NIH). The research of J.R.S. is supported by NIH
   (R01 HL73101-08 and R01 HL107910-03) and Veterans Affairs Merit System
   0018.
CR Ahlborg G, 2002, J APPL PHYSIOL, V93, P2112, DOI 10.1152/japplphysiol.00477.2002
   Balletshofer BM, 2000, CIRCULATION, V101, P1780, DOI 10.1161/01.CIR.101.15.1780
   Barac A, 2007, HYPERTENSION, V49, P748, DOI 10.1161/01.HYP.0000259601.38807.a6
   BARON AD, 1991, J CLIN ENDOCR METAB, V73, P637, DOI 10.1210/jcem-73-3-637
   Beckman JA, 2003, AM J PHYSIOL-HEART C, V285, pH2392, DOI 10.1152/ajpheart.00403.2003
   Bonetti PO, 2003, ARTERIOSCL THROM VAS, V23, P168, DOI 10.1161/01.ATV.0000051384.43104.FC
   Bonetti PO, 2004, J AM COLL CARDIOL, V44, P2137, DOI 10.1016/j.jacc.2004.08.062
   Caballero AE, 1999, DIABETES, V48, P1856, DOI 10.2337/diabetes.48.9.1856
   Cardillo C, 2004, HYPERTENSION, V43, P36, DOI 10.1161/01.HYP.0000103868.45064.81
   Cardillo C, 2002, CIRCULATION, V105, P452, DOI 10.1161/hc0402.102989
   Cardillo C, 1999, CIRCULATION, V100, P820, DOI 10.1161/01.CIR.100.8.820
   Cardillo C, 2002, CIRCULATION, V106, P1783, DOI 10.1161/01.CIR.0000032260.01569.64
   Chen H, 2006, AM J PHYSIOL-HEART C, V290, pH137, DOI 10.1152/ajpheart.00768.2005
   Darko D, 2002, CLIN SCI, V103, P339, DOI 10.1042/cs1030339
   Davis BJ, 2006, DIABETES, V55, P496, DOI 10.2337/diabetes.55.02.06.db05-1064
   DEFRONZO RA, 1991, DIABETES CARE, V14, P173, DOI 10.2337/diacare.14.3.173
   Diamanti-Kandarakis E, 2005, EUR J ENDOCRINOL, V152, P749, DOI 10.1530/eje.1.01910
   Dudzinski DM, 2007, CARDIOVASC RES, V75, P247, DOI 10.1016/j.cardiores.2007.03.023
   Duncan ER, 2008, DIABETES, V57, P3307, DOI 10.2337/db07-1111
   Eddy D, 2009, DIABETES CARE, V32, P361, DOI 10.2337/dc08-0854
   Federici M, 2004, CIRCULATION, V109, P399, DOI 10.1161/01.CIR.0000109498.77895.6F
   Fernández-Hernando C, 2007, CELL METAB, V6, P446, DOI 10.1016/j.cmet.2007.10.007
   Grassi D, 2005, HYPERTENSION, V46, P398, DOI 10.1161/01.HYP.0000174990.46027.70
   Hambrecht R, 2003, CIRCULATION, V107, P3152, DOI 10.1161/01.CIR.0000074229.93804.5C
   Hamburg NM, 2008, CIRCULATION, V117, P2467, DOI 10.1161/CIRCULATIONAHA.107.748574
   Hamdy O, 2003, DIABETES CARE, V26, P2119, DOI 10.2337/diacare.26.7.2119
   Han KA, 2011, DIABETES-METAB RES, V27, P354, DOI 10.1002/dmrr.1183
   Heitzer T, 2001, FREE RADICAL BIO MED, V31, P53, DOI 10.1016/S0891-5849(01)00551-2
   Heitzer T, 2000, DIABETOLOGIA, V43, P1435, DOI 10.1007/s001250051551
   Herman AG, 2005, EUR HEART J, V26, P1945, DOI 10.1093/eurheartj/ehi333
   Hogikyan RV, 1998, J CLIN ENDOCR METAB, V83, P1946, DOI 10.1210/jc.83.6.1946
   Hotta K, 2000, ARTERIOSCL THROM VAS, V20, P1595, DOI 10.1161/01.ATV.20.6.1595
   Jaap AJ, 1997, DIABETOLOGIA, V40, P238, DOI 10.1007/s001250050669
   Jiang ZY, 1999, J CLIN INVEST, V104, P447, DOI 10.1172/JCI5971
   Ketel IJG, 2008, J CLIN ENDOCR METAB, V93, P3365, DOI 10.1210/jc.2008-0626
   Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213
   Kubota T, 2003, CIRCULATION, V107, P3073, DOI 10.1161/01.CIR.0000070937.52035.25
   Lekakis JP, 2000, DIABETES CARE, V23, P1432, DOI 10.2337/diacare.23.9.1432a
   LERMAN A, 1991, NEW ENGL J MED, V325, P997, DOI 10.1056/NEJM199110033251404
   Lind L, 2008, ATHEROSCLEROSIS, V196, P795, DOI 10.1016/j.atherosclerosis.2007.01.014
   Lteif AA, 2005, CIRCULATION, V112, P32, DOI 10.1161/CIRCULATIONAHA.104.520130
   Lteif A, 2007, DIABETES, V56, P728, DOI 10.2337/db06-1406
   Maeda S, 2006, EXP BIOL MED, V231, P1044
   Mather KJ, 2002, DIABETES, V51, P3517, DOI 10.2337/diabetes.51.12.3517
   Montagnani M, 2002, J BIOL CHEM, V277, P1794, DOI 10.1074/jbc.M103728200
   Mukai Y, 2007, AM J PHYSIOL-HEART C, V292, pH1937, DOI 10.1152/ajpheart.00868.2006
   Muniyappa R, 2008, AM J CLIN NUTR, V88, P1685, DOI 10.3945/ajcn.2008.26457
   Muniyappa R, 2007, ENDOCR REV, V28, P463, DOI 10.1210/er.2007-0006
   Muris DM, 2012, ARTERIOSCLER THROMB
   Natali A, 1997, CIRCULATION, V96, P849
   Natali A, 2004, DIABETES CARE, V27, P1349, DOI 10.2337/diacare.27.6.1349
   Nyström T, 2004, AM J PHYSIOL-ENDOC M, V287, pE919, DOI 10.1152/ajpendo.00046.2004
   Okon EB, 2005, DIABETES, V54, P2415, DOI 10.2337/diabetes.54.8.2415
   Peña AS, 2007, DIABETES CARE, V30, P2122, DOI 10.2337/dc06-2505
   Perticone F, 2004, J CLIN ENDOCR METAB, V89, P3606, DOI 10.1210/jc.2003-032161
   Perticone F, 2001, DIABETES, V50, P159, DOI 10.2337/diabetes.50.1.159
   Petersen KF, 2007, P NATL ACAD SCI USA, V104, P12587, DOI 10.1073/pnas.0705408104
   Petrie JR, 1996, CIRCULATION, V93, P1331, DOI 10.1161/01.CIR.93.7.1331
   Poirier P, 2006, CIRCULATION, V113, P898, DOI 10.1161/CIRCULATIONAHA.106.171016
   Potenza MA, 2005, AM J PHYSIOL-HEART C, V289, pH813, DOI 10.1152/ajpheart.00092.2005
   Prior JO, 2005, CIRCULATION, V111, P2291, DOI 10.1161/01.CIR.0000164232.62768.51
   Regensteiner JG, 2003, VASC MED, V8, P169, DOI 10.1191/1358863x03vm489oa
   Semple RK, 2009, J CLIN INVEST, V119, P315, DOI 10.1172/JCI37432
   Shemyakin A, 2006, J CARDIOVASC PHARM, V47, P385
   Sola S, 2005, CIRCULATION, V111, P343, DOI 10.1161/01.CIR.0000153272.48711.B9
   Steinberg HO, 1996, J CLIN INVEST, V97, P2601, DOI 10.1172/JCI118709
   Tack CJJ, 1998, DIABETOLOGIA, V41, P569, DOI 10.1007/s001250050948
   Title LM, 2008, VASC MED, V13, P263, DOI 10.1177/1358863X08095154
   Title LM, 2006, VASC MED, V11, P101, DOI 10.1191/1358863x06vm664oa
   Turner RC, 1998, LANCET, V352, P854, DOI 10.1016/s0140-6736(98)07037-8
   Vicent D, 2003, J CLIN INVEST, V111, P1373, DOI 10.1172/JCI200315211
   Vincent MA, 2004, DIABETES, V53, P1418, DOI 10.2337/diabetes.53.6.1418
   Vincent Michelle A, 2003, Curr Diab Rep, V3, P279, DOI 10.1007/s11892-003-0018-9
   Watts GF, 1996, CLIN SCI, V91, P567, DOI 10.1042/cs0910567
   Wendelhag I, 2002, J INTERN MED, V252, P305, DOI 10.1046/j.1365-2796.2002.01036.x
   Wheatcroft SB, 2004, DIABETES, V53, P2645, DOI 10.2337/diabetes.53.10.2645
   Williams SB, 1996, J AM COLL CARDIOL, V27, P567, DOI 10.1016/0735-1097(95)00522-6
   Zeng GY, 1996, J CLIN INVEST, V98, P894, DOI 10.1172/JCI118871
NR 78
TC 367
Z9 400
U1 0
U2 62
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1389-9155
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD MAR
PY 2013
VL 14
IS 1
BP 5
EP 12
DI 10.1007/s11154-012-9229-1
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 098SC
UT WOS:000315568000002
PM 23306778
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kino, T
AF Kino, Tomoshige
TI Circadian Rhythms of Glucocorticoid Hormone Actions in Target Tissues:
   Potential Clinical Implications
SO SCIENCE SIGNALING
LA English
DT Article
ID STRESS SYSTEM; CLOCK; RECEPTOR; EXPRESSION; DEPRESSION; DISORDERS;
   MECHANISM; COMPLEX
AB Organisms face unforeseen short- and long-term changes in the environment (stressors). To defend against these changes, organisms have developed a stress system that includes the hypothalamic-pituitary-adrenal (HPA) axis, which employs glucocorticoids and the glucocorticoid receptor (GR) for signal transduction. In addition, organisms live under the strong influence of day-night cycles and, hence, have also developed a highly conserved circadian clock system for adjusting their activities to recurring environmental changes. This regulatory system creates and maintains internal circadian rhythmicity by employing a self-oscillating molecular pacemaker composed of the Clock-Bmal1 heterodimer and other transcription factors. The circadian clock consists of a central master clock in the suprachiasmatic nucleus of the brain hypothalamus and peripheral slave clocks in virtually all organs and tissues. The HPA axis and the circadian clock system communicate with each other at multiple levels. The central clock controls the HPA axis, creating the diurnal oscillation of circulating adrenocorticotropic hormone and cortisol, and the HPA axis adjusts the circadian rhythmicity of the peripheral clocks in response to various stressors through the GR. Further, Clock-Bmal1 regulates the response to glucocorticoids in peripheral tissues through acetylation of the GR, possibly antagonizing the biologic actions of diurnally fluctuating circulating cortisol. Importantly, dysregulation in the clock system and the HPA axis may cause similar pathologic manifestations-including obesity, metabolic syndrome, and cardiovascular disease-by uncoupling circulating cortisol concentrations from tissue sensitivity to glucocorticoids.
C1 Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver
   National Institute of Child Health & Human Development (NICHD)
RP Kino, T (corresponding author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20892 USA.
EM kinot@mail.nih.gov
FU Intramural Research Program of NICHD, NIH; Athens University Medical
   School
FX The studies presented were funded by the Intramural Research Program of
   NICHD, NIH, and the Athens University Medical School.
CR [Anonymous], HDB STRESS BRAIN, DOI DOI 10.1016/j.neuropharm.2008.06.046
   Balsalobre A, 2000, SCIENCE, V289, P2344, DOI 10.1126/science.289.5488.2344
   Bao AM, 2008, BRAIN RES REV, V57, P531, DOI 10.1016/j.brainresrev.2007.04.005
   Cermakian N, 2000, NAT REV MOL CELL BIO, V1, P59, DOI 10.1038/35036078
   Charmandari E, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025612
   Chen HW, 1997, CELL, V90, P569, DOI 10.1016/S0092-8674(00)80516-4
   Chrousos GP, 2007, STRESS, V10, P213, DOI 10.1080/10253890701292119
   Chrousos GP, 2009, NAT REV ENDOCRINOL, V5, P374, DOI 10.1038/nrendo.2009.106
   CHROUSOS GP, 1995, NEW ENGL J MED, V332, P1351, DOI 10.1056/NEJM199505183322008
   CHROUSOS GP, 1992, JAMA-J AM MED ASSOC, V267, P1244, DOI 10.1001/jama.267.9.1244
   Doi M, 2006, CELL, V125, P497, DOI 10.1016/j.cell.2006.03.033
   GIGUERE V, 1986, CELL, V46, P645, DOI 10.1016/0092-8674(86)90339-9
   Gold PW, 2002, MOL PSYCHIATR, V7, P254, DOI 10.1038/sj.mp.4001032
   HOLLENBERG SM, 1985, NATURE, V318, P635, DOI 10.1038/318635a0
   Ishida A, 2005, CELL METAB, V2, P297, DOI 10.1016/j.cmet.2005.09.009
   Kalsbeek A, 2006, J BIOL RHYTHM, V21, P458, DOI 10.1177/0748730406293854
   Kino T, 2011, CLIN EXP RHEUMATOL, V29, pS32
   Kino T, 2003, J STEROID BIOCHEM, V85, P457, DOI 10.1016/S0960-0760(03)00218-8
   Kino T, 2011, MOL CELL ENDOCRINOL, V336, P23, DOI 10.1016/j.mce.2010.12.001
   Kino T, 2011, ENDOCR DEV, V20, P116, DOI 10.1159/000321232
   Ko CH, 2006, HUM MOL GENET, V15, pR271, DOI 10.1093/hmg/ddl207
   Lamia KA, 2011, NATURE, V480, P552, DOI 10.1038/nature10700
   Lightman SL, 2008, EUR J PHARMACOL, V583, P255, DOI 10.1016/j.ejphar.2007.11.073
   McNamara P, 2001, CELL, V105, P877, DOI 10.1016/S0092-8674(01)00401-9
   Meijer JH, 2003, J BIOL RHYTHM, V18, P235, DOI 10.1177/0748730403253370
   Nader N, 2010, TRENDS ENDOCRIN MET, V21, P277, DOI 10.1016/j.tem.2009.12.011
   Nader N, 2009, FASEB J, V23, P1572, DOI 10.1096/fj.08-117697
   Oster H, 2006, CELL METAB, V4, P163, DOI 10.1016/j.cmet.2006.07.002
   Scheer FAJL, 2009, P NATL ACAD SCI USA, V106, P4453, DOI 10.1073/pnas.0808180106
   Schmutz I, 2010, GENE DEV, V24, P345, DOI 10.1101/gad.564110
   Son GH, 2008, P NATL ACAD SCI USA, V105, P20970, DOI 10.1073/pnas.0806962106
   Staels B, 2006, NAT MED, V12, P54, DOI 10.1038/nm0106-54
   Takahashi JS, 2008, NAT REV GENET, V9, P764, DOI 10.1038/nrg2430
   Yoshikawa T, 2009, ENDOCRINOLOGY, V150, P4338, DOI 10.1210/en.2008-1280
NR 34
TC 30
Z9 35
U1 0
U2 18
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 1945-0877
EI 1937-9145
J9 SCI SIGNAL
JI Sci. Signal.
PD OCT 2
PY 2012
VL 5
IS 244
AR pt4
DI 10.1126/scisignal.2003333
PG 5
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 022JI
UT WOS:000309954100006
PM 23033538
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Schläfli, P
   Borter, E
   Spielmann, P
   Wenger, RH
AF Schlafli, P.
   Borter, E.
   Spielmann, P.
   Wenger, R. H.
TI The PAS-domain kinase PASKIN: a new sensor in energy homeostasis
SO CELLULAR AND MOLECULAR LIFE SCIENCES
LA English
DT Review
DE Diabetes mellitus; glucose tolerance; glycogen synthesis; insulin;
   metabolic syndrome; nitrogen fixation; protein translation; respiration
ID SERINE/THREONINE KINASE; OXYGEN; EXPRESSION; TRANSCRIPTION; TRANSLATION;
   DEFICIENT; HYPOXIA; CLONING
AB The PAS domain kinase PASKIN, also termed PAS kinase or PASK, is an evolutionarily conserved potential sensor kinase related to the heme-based oxygen sensors of nitrogen-fixing bacteria. In yeast, the two PASKIN homologs link energy flux and protein synthesis following specific stress conditions. In mammals, PASKIN may regulate glycogen synthesis and protein translation. Paskin knock-out mice do not show any phenotype under standard animal husbandry conditions. Interestingly, these mice seem to be protected from the symptoms of the metabolic syndrome when fed a high-fat diet. Energy turnover might be increased in specific PASKIN-deficient cell types under distinct environmental conditions. According to the current model, binding of a putative ligand to the PAS domain disinhibits the kinase domain and activates PASKIN auto- and target phosphorylation. Future research needs to be conducted to elucidate the nature of the putative ligand and the molecular mechanisms of downstream signalling by PASKIN.
C1 [Schlafli, P.; Borter, E.; Spielmann, P.; Wenger, R. H.] Univ Zurich, Inst Physiol & Zurich, Ctr Integrat Human Physiol, Winterthurerstr 190, CH-8057 Zurich, Switzerland.
C3 University of Zurich; Zurich Center Integrative Human Physiology (ZIHP)
RP Wenger, RH (corresponding author), Univ Zurich, Inst Physiol & Zurich, Ctr Integrat Human Physiol, Winterthurerstr 190, CH-8057 Zurich, Switzerland.
EM roland.wenger@access.uzh.ch
RI ; Wenger, Roland H./B-7953-2009
OI Spielmann, Patrick/0000-0001-7056-0351; Wenger, Roland
   H./0000-0001-7592-4839
FU Wolfermann-Nageli-Stiftung; Baugarten Stiftung/Stiftung fur
   Wissenschaftliche Forschung an der Universitat Zurich; Swiss National
   Science Foundation (SNF ) [3100AO-116047/1]
FX Our work is supported by grants obtained from the
   Wolfermann-Nageli-Stiftung, Baugarten Stiftung/Stiftung fur
   Wissenschaftliche Forschung an der Universitat Zurich and the Swiss
   National Science Foundation (SNF 3100AO-116047/1). The authors wish to
   thank C. Aerni, P. Wielinga, B. Alder, C. Loewenstein, T. Lutz, I.
   Tobler, J. Lopez-Barneo, M. Donath, W. Langhans and J. Hillebrand for
   analysis of Paskin knock-out mice and sharing their unpublished data.
CR Amezcua CA, 2002, STRUCTURE, V10, P1349, DOI 10.1016/S0969-2126(02)00857-2
   An R, 2006, BIOCHEM SOC T, V34, P791, DOI 10.1042/BST0340791
   Beausoleil SA, 2004, P NATL ACAD SCI USA, V101, P12130, DOI 10.1073/pnas.0404720101
   Borter E, 2007, DIABETES, V56, P113, DOI 10.2337/db06-0798
   Cabral JHM, 1998, CELL, V95, P649, DOI 10.1016/S0092-8674(00)81635-9
   Card PB, 2005, J MOL BIOL, V353, P664, DOI 10.1016/j.jmb.2005.08.043
   CHEN H, 1995, NAT GENET, V10, P9, DOI 10.1038/ng0595-9
   Chrast R, 1997, GENOME RES, V7, P615, DOI 10.1101/gr.7.6.615
   Crews ST, 1998, GENE DEV, V12, P607, DOI 10.1101/gad.12.5.607
   da Silva Xavier G, 2004, P NATL ACAD SCI USA, V101, P8319, DOI 10.1073/pnas.0307737101
   Dioum EM, 2002, SCIENCE, V298, P2385, DOI 10.1126/science.1078456
   Eckhardt K, 2007, CELL PHYSIOL BIOCHEM, V20, P227, DOI 10.1159/000104169
   Grose JH, 2007, EMBO J, V26, P4824, DOI 10.1038/sj.emboj.7601914
   Gu YZ, 2000, ANNU REV PHARMACOL, V40, P519, DOI 10.1146/annurev.pharmtox.40.1.519
   Hao HX, 2008, IUBMB LIFE, V60, P204, DOI 10.1002/iub.32
   Hao HX, 2007, P NATL ACAD SCI USA, V104, P15466, DOI 10.1073/pnas.0705407104
   Hofer T, 2001, BIOCHEM BIOPH RES CO, V288, P757, DOI 10.1006/bbrc.2001.5840
   Katschinski DM, 2003, MOL CELL BIOL, V23, P6780, DOI 10.1128/MCB.23.19.6780-6789.2003
   Lowrey PL, 2000, ANNU REV GENET, V34, P533, DOI 10.1146/annurev.genet.34.1.533
   Marvin KA, 2008, BIOCHEMISTRY-US, V47, P9016, DOI 10.1021/bi800486x
   Miao N, 2000, J HISTOCHEM CYTOCHEM, V48, P1391, DOI 10.1177/002215540004801009
   Mimura J, 2003, BBA-GEN SUBJECTS, V1619, P263, DOI 10.1016/S0304-4165(02)00485-3
   Miyatake H, 2000, J MOL BIOL, V301, P415, DOI 10.1006/jmbi.2000.3954
   Ponting CP, 1997, CURR BIOL, V7, pR674, DOI 10.1016/S0960-9822(06)00352-6
   Rutter J, 2002, CELL, V111, P17, DOI 10.1016/S0092-8674(02)00974-1
   Rutter J, 2001, P NATL ACAD SCI USA, V98, P8991, DOI 10.1073/pnas.161284798
   Schofield CJ, 2004, NAT REV MOL CELL BIO, V5, P343, DOI 10.1038/nrm1366
   Smith TL, 2007, MOL CELL, V26, P491, DOI 10.1016/j.molcel.2007.03.025
   Soliz J, 2008, AM J PHYSIOL-REG I, V295, pR649, DOI 10.1152/ajpregu.00876.2007
   Sousa EHS, 2007, BIOCHEMISTRY-US, V46, P6249, DOI 10.1021/bi7003334
   Taylor BL, 1999, MICROBIOL MOL BIOL R, V63, P479, DOI 10.1128/MMBR.63.2.479-506.1999
   Ushiro H, 1998, ARCH BIOCHEM BIOPHYS, V355, P233, DOI 10.1006/abbi.1998.0736
   Wenger RH, 2005, SEMIN CELL DEV BIOL, V16, P547, DOI 10.1016/j.semcdb.2005.03.008
   Wenger RH, 2002, FASEB J, V16, DOI 10.1096/fj.01-0944rev
   Wilson WA, 2005, P NATL ACAD SCI USA, V102, P16596, DOI 10.1073/pnas.0508481102
   Zhulin IB, 1997, TRENDS BIOCHEM SCI, V22, P331, DOI 10.1016/S0968-0004(97)01110-9
NR 36
TC 25
Z9 31
U1 0
U2 10
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1420-682X
EI 1420-9071
J9 CELL MOL LIFE SCI
JI Cell. Mol. Life Sci.
PD MAR
PY 2009
VL 66
IS 5
BP 876
EP 883
DI 10.1007/s00018-009-8699-0
PG 8
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 413XP
UT WOS:000263826400010
PM 19189049
OA Green Published
DA 2025-06-11
ER

PT J
AU Saiah, E
AF Saiah, Eddine
TI The role of 11beta-hydroxysteroid dehydrogenase in metabolic disease and
   therapeutic potential of 11beta-HSD1 inhibitors
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE 11beta-HSD1; glucocorticoid; metabolic syndrome; diabetes; obesity
ID BETA-KETO SULFONES; SELECTIVE INHIBITORS; 11-BETA-HSD1; DISCOVERY;
   TYPE-1; HYPERGLYCEMIA; RECEPTOR; OBESITY; TARGET
AB Glucocorticoids play an essential role in the regulation of multiple physiological processes, including energy metabolism, maintenance of blood pressure and stress responses, as well as cognitive functions. On a tissue-specific level, glucocorticoid action is controlled by 11beta-hydroxysteroid dehydrogenase enzymes. The type 1 enzyme (11beta-HSD1) is a NADP(H)-dependent bidirectional enzyme in vitro and reduces cortisone to active cortisol in vivo. 11beta-HSD1 is expressed in many tissues including the liver, adipose and skeletal muscles. Chronically elevated local glucocorticoid action as a result of increased 11beta-HSD1 activity has been associated with the metabolic syndrome, which is characterized by obesity, insulin resistance, type 2 diabetes and cardiovascular complications. Recent studies indicate that the inhibition of 11beta-HSD1 mitigates the adverse effects of excessive glucocorticoid levels on metabolic parameters and provides promising opportunities for the development of therapeutic interventions. This review discusses recently disclosed 11beta-HSD1 inhibitors and their potential for the treatment of metabolic disorders.
C1 Wyeth Res, Cambridge, MA 02140 USA.
C3 Pfizer; Wyeth; Pfizer USA
RP Saiah, E (corresponding author), Wyeth Res, 200 Cambridge Pk Dr, Cambridge, MA 02140 USA.
EM esaiah@wyeth.com
CR Barf T, 2002, J MED CHEM, V45, P3813, DOI 10.1021/jm025530f
   BERTHIAUME M, 2007, IN PRESS AM J P 0731
   Berthiaume M, 2007, ENDOCRINOLOGY, V148, P2391, DOI 10.1210/en.2006-1199
   Bujalska IJ, 1997, LANCET, V349, P1210, DOI 10.1016/S0140-6736(96)11222-8
   Coppola GM, 2005, J MED CHEM, V48, P6696, DOI 10.1021/jm058228q
   Flyrén K, 2007, BIOORG MED CHEM LETT, V17, P3421, DOI 10.1016/j.bmcl.2007.03.083
   Fox CS, 2006, CIRCULATION, V113, P2914, DOI 10.1161/CIRCULATIONAHA.106.613828
   Friedman JE, 1997, J BIOL CHEM, V272, P31475, DOI 10.1074/jbc.272.50.31475
   Gu X, 2005, BIOORG MED CHEM LETT, V15, P5266, DOI 10.1016/j.bmcl.2005.08.052
   Hermanowski-Vosatka A, 2005, J EXP MED, V202, P517, DOI 10.1084/jem.20050119
   Hirasawa G, 1997, J CLIN ENDOCR METAB, V82, P3859, DOI 10.1210/jc.82.11.3859
   Jean DJS, 2007, J MED CHEM, V50, P429, DOI 10.1021/jm061214f
   Kotelevtsev Y, 1997, P NATL ACAD SCI USA, V94, P14924, DOI 10.1073/pnas.94.26.14924
   LEHMANN JM, 1995, J BIOL CHEM, V270, P12953, DOI 10.1074/jbc.270.22.12953
   Livingstone DEW, 2003, J PHARMACOL EXP THER, V305, P167, DOI 10.1124/jpet.102.044842
   Masuzaki H, 2003, J CLIN INVEST, V112, P83, DOI [10.1172/JCI200317845, 10.1172/JCI17845]
   Masuzaki H, 2001, SCIENCE, V294, P2166, DOI 10.1126/science.1066285
   Olson S, 2005, BIOORG MED CHEM LETT, V15, P4359, DOI 10.1016/j.bmcl.2005.06.040
   Patel JR, 2007, BIOORG MED CHEM LETT, V17, P750, DOI 10.1016/j.bmcl.2006.10.074
   Richards S, 2006, BIOORG MED CHEM LETT, V16, P6241, DOI 10.1016/j.bmcl.2006.09.035
   Rohde JJ, 2007, J MED CHEM, V50, P149, DOI 10.1021/jm0609364
   Sarabu R, 2005, ANNU REP MED CHEM, V40, P167, DOI 10.1016/S0065-7743(05)40011-1
   Shimojo M, 1997, ENDOCRINOLOGY, V138, P1305, DOI 10.1210/en.138.3.1305
   Sorensen B, 2007, BIOORG MED CHEM LETT, V17, P527, DOI 10.1016/j.bmcl.2006.10.008
   Sorensen B, 2006, BIOORG MED CHEM LETT, V16, P5958, DOI 10.1016/j.bmcl.2006.08.129
   Sukhija R, 2006, AM J CARDIOL, V98, P544, DOI 10.1016/j.amjcard.2006.03.028
   Sutin L, 2007, BIOORG MED CHEM LETT, V17, P4837, DOI 10.1016/j.bmcl.2007.06.054
   Tomlinson JW, 2005, NAT CLIN PRACT ENDOC, V1, P92, DOI 10.1038/ncpendmet0023
   Wamil M, 2007, DRUG DISCOV TODAY, V12, P504, DOI 10.1016/j.drudis.2007.06.001
   Xiang J, 2005, BIOORG MED CHEM LETT, V15, P2865, DOI 10.1016/j.bmcl.2005.03.093
   Xiang J, 2007, BIOORGAN MED CHEM, V15, P4396, DOI 10.1016/j.bmc.2007.04.035
   Yeh VSC, 2006, BIOORG MED CHEM LETT, V16, P5555, DOI 10.1016/j.bmcl.2006.08.034
   Yeh VSC, 2006, BIOORG MED CHEM LETT, V16, P5408, DOI 10.1016/j.bmcl.2006.07.062
   Yeh VSC, 2006, BIOORG MED CHEM LETT, V16, P5414, DOI 10.1016/j.bmcl.2006.07.055
NR 34
TC 40
Z9 50
U1 1
U2 8
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PD MAR
PY 2008
VL 15
IS 7
BP 642
EP 649
DI 10.2174/092986708783885264
PG 8
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 274GU
UT WOS:000253990600002
PM 18336279
DA 2025-06-11
ER

PT J
AU Tóth, ME
   Sárközy, M
   Szucs, G
   Dukay, B
   Hajdu, P
   Zvara, A
   Puskás, LG
   Szebeni, GJ
   Ruppert, Z
   Csonka, C
   Kovács, F
   Kriston, A
   Horváth, P
   Kovári, B
   Cserni, G
   Csont, T
   Sántha, M
AF Toth, Melinda E.
   Sarkozy, Marta
   Szucs, Gergo
   Dukay, Brigitta
   Hajdu, Petra
   Zvara, Agnes
   Puskas, Laszlo G.
   Szebeni, Gabor J.
   Ruppert, Zsofia
   Csonka, Csaba
   Kovacs, Ferenc
   Kriston, Andras
   Horvath, Peter
   Kovari, Bence
   Cserni, Gabor
   Csont, Tamas
   Santha, Miklos
TI Exercise training worsens cardiac performance in males but does not
   change ejection fraction and improves hypertrophy in females in a mouse
   model of metabolic syndrome
SO BIOLOGY OF SEX DIFFERENCES
LA English
DT Article
DE Metabolic syndrome; Hyperlipidemia; Obesity; Endoplasmic reticulum
   stress; Sex-based differences; Endurance training; Cardio-metabolic
   disease; Heart failure; Left ventricular hypertrophy; Diastolic function
ID HUMAN APOLIPOPROTEIN-B; HEAT-SHOCK PROTEINS; SEX-DIFFERENCES; FAILURE;
   LEPTIN; STRESS; GENDER; RAT; NEURODEGENERATION; OVEREXPRESSION
AB Background Metabolic syndrome (MetS) refers to a cluster of co-existing cardio-metabolic risk factors, including visceral obesity, dyslipidemia, hyperglycemia with insulin resistance, and hypertension. As there is a close link between MetS and cardiovascular diseases, we aimed to investigate the sex-based differences in MetS-associated heart failure (HF) and cardiovascular response to regular exercise training (ET). Methods High-fat diet-fed male and female APOB-100 transgenic (HFD/APOB-100, 3 months) mice were used as MetS models, and age- and sex-matched C57BL/6 wild-type mice on standard diet served as healthy controls (SD/WT). Both the SD/WT and HFD/APOB-100 mice were divided into sedentary and ET groups, the latter running on a treadmill (0.9 km/h) for 45 min 5 times per week for 7 months. At month 9, transthoracic echocardiography was performed to monitor cardiac function and morphology. At the termination of the experiment at month 10, blood was collected for serum low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol measurements and homeostatic assessment model for insulin resistance (HOMA-IR) calculation. Cardiomyocyte hypertrophy and fibrosis were assessed by histology. Left ventricular expressions of selected genes associated with metabolism, inflammation, and stress response were investigated by qPCR. Results Both HFD/APOB-100 males and females developed obesity and hypercholesterolemia; however, only males showed insulin resistance. ET did not change these metabolic parameters. HFD/APOB-100 males showed echocardiographic signs of mild HF with dilated ventricles and thinner walls, whereas females presented the beginning of left ventricular hypertrophy. In response to ET, SD/WT males developed increased left ventricular volumes, whereas females responded with physiologic hypertrophy. Exercise-trained HFD/APOB-100 males presented worsening HF with reduced ejection fraction; however, ET did not change the ejection fraction and reversed the echocardiographic signs of left ventricular hypertrophy in HFD/APOB-100 females. The left ventricular expression of the leptin receptor was higher in females than males in the SD/WT groups. Left ventricular expression levels of stress response-related genes were higher in the exercise-trained HFD/APOB-100 males and exercise-trained SD/WT females than exercise-trained SD/WT males. Conclusions HFD/APOB-100 mice showed sex-specific cardiovascular responses to MetS and ET; however, left ventricular gene expressions were similar between the groups except for leptin receptor and several stress response-related genes.
C1 [Toth, Melinda E.; Dukay, Brigitta; Hajdu, Petra; Ruppert, Zsofia; Santha, Miklos] Eotvos Lorand Res Network, Lab Anim Genet & Mol Neurobiol, Biol Res Ctr, Inst Biochem, Temesvari Krt 62, H-6726 Szeged, Hungary.
   [Sarkozy, Marta; Szucs, Gergo; Csonka, Csaba; Csont, Tamas] Univ Szeged, Albert Szent Gyorgyi Med Sch, Dept Biochem, MED Res Grp, Dom Ter 9, H-6720 Szeged, Hungary.
   [Sarkozy, Marta; Szucs, Gergo; Csonka, Csaba; Csont, Tamas] Univ Szeged, Interdisciplinary Ctr Excellence, Dugon Ter 13, H-6720 Szeged, Hungary.
   [Zvara, Agnes; Puskas, Laszlo G.; Szebeni, Gabor J.] Eotvos Lorand Res Network, Biol Res Ctr, Lab Funct Genom, Temesvari Krt 62, H-6726 Szeged, Hungary.
   [Ruppert, Zsofia] Univ Szeged, Doctoral Sch Biol, Szeged, Hungary.
   [Kovacs, Ferenc; Kriston, Andras; Horvath, Peter] Eotvos Lorand Res Network, Inst Biochem, Biol Res Ctr, Synthet & Syst Biol Unit, Temesvari Krt 62, H-6726 Szeged, Hungary.
   [Kovacs, Ferenc; Kriston, Andras; Horvath, Peter] Single Cell Technol Ltd, Temesvari Krt 62, H-6726 Szeged, Hungary.
   [Horvath, Peter] Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki 00014, Finland.
   [Kovari, Bence; Cserni, Gabor] Univ Szeged, Albert Szent Gyorgyi Med Sch, Dept Pathol, Allomas Utca 1, H-6720 Szeged, Hungary.
C3 HUN-REN; HUN-REN Biological Research Center; Institute of Biochemistry -
   HAS; Szeged University; Szeged University; HUN-REN; HUN-REN Biological
   Research Center; Szeged University; HUN-REN; HUN-REN Biological Research
   Center; Institute of Biochemistry - HAS; University of Helsinki; Szeged
   University
RP Tóth, ME (corresponding author), Eotvos Lorand Res Network, Lab Anim Genet & Mol Neurobiol, Biol Res Ctr, Inst Biochem, Temesvari Krt 62, H-6726 Szeged, Hungary.; Sárközy, M (corresponding author), Univ Szeged, Albert Szent Gyorgyi Med Sch, Dept Biochem, MED Res Grp, Dom Ter 9, H-6720 Szeged, Hungary.; Sárközy, M (corresponding author), Univ Szeged, Interdisciplinary Ctr Excellence, Dugon Ter 13, H-6720 Szeged, Hungary.
EM toth.erzsebetmelinda@brc.hu; sarkozy.marta@med.u-szeged.hu
RI Kovari, Bence/AAA-3346-2021; Szűcs, Gergő/O-8732-2019; Kovács,
   Ferenc/ABB-1658-2021; Cserni, Gabor/JCN-6784-2023; Sarkozy,
   Marta/G-1657-2016
OI Toth, Melinda/0000-0002-5529-6967; Szebeni, Gabor
   J./0000-0002-6998-5632; Szucs, Gergo/0000-0003-1874-2718; Sarkozy,
   Marta/0000-0002-5929-2146
FU New National Excellence Program of the Ministry of Human Capacities
   [UNKP-20-5-SZTE-166, UNKP-19-4-SZTE-89]; Janos Bolyai Research
   Fellowship of the Hungarian Academy of Sciences; Ministry for Innovation
   and Technology [UNKP-21-4-SZTE-483];  [GINOP-2.3.2-152016-00040]; 
   [GINOP-2.3.2-15-2016-00060];  [NKFIH K115990];  [NKFIH FK129094]; 
   [NKFIH FK138390];  [TKP2021-EGA-32];  [20391-3/2018/FEKUSTRAT]
FX This research and publication were funded by the projects
   GINOP-2.3.2-152016-00040, GINOP-2.3.2-15-2016-00060, NKFIH K115990,
   NKFIH FK129094, NKFIH FK138390, TKP2021-EGA-32 and
   20391-3/2018/FEKUSTRAT. MS (Marta Sarkozy) is supported by the New
   National Excellence Program of the Ministry of Human Capacities
   (UNKP-20-5-SZTE-166, UNKP-19-4-SZTE-89) and the Janos Bolyai Research
   Fellowship of the Hungarian Academy of Sciences. BD is supported by the
   UNKP-21-4-SZTE-483 New National Excellence Program of the Ministry for
   Innovation and Technology.
CR Arnett DK, 2019, CIRCULATION, V140, pE563, DOI [10.1016/j.jacc.2019.03.009, 10.1016/j.jacc.2019.03.010, 10.1161/CIR.0000000000000678, 10.1161/CIR.0000000000000677]
   Aroor AR, 2012, HEART FAIL CLIN, V8, P609, DOI 10.1016/j.hfc.2012.06.005
   Banerjee I, 2007, AM J PHYSIOL-HEART C, V293, pH1883, DOI 10.1152/ajpheart.00514.2007
   Barr ELM, 2010, DIABETOLOGIA, V53, P79, DOI 10.1007/s00125-009-1588-0
   BarrettConnor E, 1997, CIRCULATION, V95, P252, DOI 10.1161/01.CIR.95.1.252
   Bereczki E, 2008, J PROTEOME RES, V7, P2246, DOI 10.1021/pr7006329
   Bjelik A, 2006, NEUROCHEM INT, V49, P393, DOI 10.1016/j.neuint.2006.01.026
   CALLOW MJ, 1994, P NATL ACAD SCI USA, V91, P2130, DOI 10.1073/pnas.91.6.2130
   Csont T, 2002, BIOCHEM BIOPH RES CO, V290, P1535, DOI 10.1006/bbrc.2002.6377
   Csont T, 2007, CARDIOVASC RES, V76, P100, DOI 10.1016/j.cardiores.2007.06.006
   de Waard AKM, 2019, EUR J PUBLIC HEALTH, V29, P88, DOI 10.1093/eurpub/cky112
   Eisenberg E, 2018, CLIN CARDIOL, V41, P211, DOI 10.1002/clc.22917
   Gerdts E, 2019, NAT MED, V25, P1657, DOI 10.1038/s41591-019-0643-8
   Guo SD, 2014, J ENDOCRINOL, V220, pT1, DOI 10.1530/JOE-13-0327
   Hall ME, 2015, WORLD J CARDIOL, V7, P511, DOI 10.4330/wjc.v7.i9.511
   Hayward CS, 2000, CARDIOVASC RES, V46, P28, DOI 10.1016/S0008-6363(00)00005-5
   Hooper PL, 2014, CELL STRESS CHAPERON, V19, P447, DOI 10.1007/s12192-014-0493-8
   Kaabia Z, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-34329-3
   Kovács ZZA, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-96815-5
   Lam CSP, 2019, EUR HEART J, V40, P3859, DOI 10.1093/eurheartj/ehz835
   Latchman DS, 2001, CARDIOVASC RES, V51, P637, DOI 10.1016/S0008-6363(01)00354-6
   Lénárt N, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046007
   Lusis AJ, 2008, NAT REV GENET, V9, P819, DOI 10.1038/nrg2468
   Martínez-Martínez E, 2014, HORM MOL BIOL CLIN I, V18, P3, DOI 10.1515/hmbci-2013-0060
   McGaffin KR, 2011, CARDIOVASC RES, V89, P60, DOI 10.1093/cvr/cvq288
   Murphy E, 2017, CARDIOVASC RES, V113, P370, DOI 10.1093/cvr/cvx008
   Nakamura M, 2018, NAT REV CARDIOL, V15, P387, DOI 10.1038/s41569-018-0007-y
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Nystoriak Matthew A, 2018, Front Cardiovasc Med, V5, P135, DOI 10.3389/fcvm.2018.00135
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Oneglia A, 2020, CURR HEART FAIL REP, V17, P409, DOI 10.1007/s11897-020-00487-7
   Oslowski CM, 2011, METHOD ENZYMOL, V490, P71, DOI 10.1016/B978-0-12-385114-7.00004-0
   Paley CA, 2018, BMC SPORTS SCI MED R, V10, DOI 10.1186/s13102-018-0097-1
   Penke B, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19010325
   Poetsch MS, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00354
   Ponikowski P, 2016, EUR HEART J, V37, P2129, DOI 10.1093/eurheartj/ehw128
   PURCELLHUYNH DA, 1995, J CLIN INVEST, V95, P2246, DOI 10.1172/JCI117915
   Qi YJ, 2013, DIABETES, V62, P3887, DOI 10.2337/db13-0095
   Quindry JC, 2007, J APPL PHYSIOL, V103, P1056, DOI 10.1152/japplphysiol.00263.2007
   Razavi AC, 2019, BIOL SEX DIFFER, V10, DOI 10.1186/s13293-019-0240-z
   Regitz-Zagrosek V, 2007, GENDER MED, V4, pS162, DOI 10.1016/S1550-8579(07)80056-8
   Sallo FB, 2009, EXP EYE RES, V89, P178, DOI 10.1016/j.exer.2009.03.006
   Salton CJ, 2002, J AM COLL CARDIOL, V39, P1055, DOI 10.1016/S0735-1097(02)01712-6
   Samali Afshin, 2010, Int J Cell Biol, V2010, P830307, DOI 10.1155/2010/830307
   Sárközy M, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-16
   Sárkozy M, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-016-0424-3
   Serrano-Ferrer J, 2016, METABOLISM, V65, P1350, DOI 10.1016/j.metabol.2016.05.006
   Swank AM, 2012, CIRC-HEART FAIL, V5, P579, DOI 10.1161/CIRCHEARTFAILURE.111.965186
   Szucs G, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/3218275
   Teixeira-Lemos E, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-12
   Tian DY, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/3756750
   Tóth ME, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22084198
   Tóth ME, 2020, CURR PHARM DESIGN, V26, P1486, DOI 10.2174/1381612826666200218101818
   Toth Melinda E., 2015, Acta Biologica Szegediensis, V59, P121
   Tune JD, 2017, TRANSL RES, V183, P57, DOI 10.1016/j.trsl.2017.01.001
   Ventura-Clapier R, 2017, CARDIOVASC RES, V113, P711, DOI 10.1093/cvr/cvx066
   Willis MS, 2010, CIRCULATION, V122, P1740, DOI 10.1161/CIRCULATIONAHA.110.942250
   Xu FP, 2004, CIRCULATION, V110, P1269, DOI 10.1161/01.CIR.0000140766.52771.6D
NR 58
TC 10
Z9 10
U1 1
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2042-6410
J9 BIOL SEX DIFFER
JI Biol. Sex Differ.
PD JAN 31
PY 2022
VL 13
IS 1
AR 5
DI 10.1186/s13293-022-00414-6
PG 19
WC Endocrinology & Metabolism; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Genetics & Heredity
GA YS2KU
UT WOS:000750512300001
PM 35101146
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lundström, S
   Jormfeldt, H
   Ahlström, BH
   Skärsäter, I
AF Lundstrom, Sofie
   Jormfeldt, Henrika
   Ahlstrom, Britt Hedman
   Skarsater, Ingela
TI Health-related lifestyle and perceived health among people with severe
   mental illness: Gender differences and degree of sense of coherence
SO ARCHIVES OF PSYCHIATRIC NURSING
LA English
DT Article
DE Health; Lifestyle; Sense of Coherence; Severe mental illness; Quality of
   Life
ID QUALITY-OF-LIFE; ANTONOVSKYS SENSE; SEDENTARY BEHAVIOR; METABOLIC
   SYNDROME; PHYSICAL-ACTIVITY; BIPOLAR DISORDER; OBESE ADULTS;
   SCHIZOPHRENIA; MORTALITY; SYMPTOMS
AB People with severe mental illness (SMI) experience an increased risk of physical ill health and premature death, which appears to be partly related to unhealthy lifestyle habits. The aim of this study was to describe the distribution of health-related lifestyle habits and perceived health among people with severe mental illness. A further aim was to explore if there were any gender differences or differences based on degree of sense of coherence. The study adopted a cross-sectional design based on data from 65 people with SMI. The results show that degree of Sense of Coherence (SOC) does have relevance for perceived health and for dimensions of Quality of Life (QOL). Furthermore, among the participants with strong SOC, there were less daily smokers and they seemed to have less sedentary leisure time than those with low SOC. Men reported more anxiety/depression than women and women ate fruit more often than men, otherwise there were no gender differences. In comparison with the general population, people with SMI show a higher Body Mass Index are more sedentary, more often daily smokers, have lower SOC and perceive a lower QOL. This emphasizes the importance of health-promotion support that focuses on lifestyle changes, and support for strengthening SOC and QOL for people with SMI.
C1 [Lundstrom, Sofie; Jormfeldt, Henrika; Skarsater, Ingela] Halmstad Univ, Sch Hlth & Welf, Kristians IV S Vag 3, S-30118 Halmstad, Sweden.
   [Ahlstrom, Britt Hedman] Univ West, Dept Hlth Sci, Trollhattan, Sweden.
C3 Halmstad University; University West - Sweden
RP Lundström, S (corresponding author), Halmstad Univ, Sch Hlth & Welf, Kristians IV S Vag 3, S-30118 Halmstad, Sweden.
EM sofie.lundstrom@hh.se
RI Ahlström, Britt/Y-8217-2019
CR [Anonymous], 2013, DIAGNOSTIC STAT MANU, VFifth, P1000
   [Anonymous], 2021, OB OV
   [Anonymous], 2015, Fact sheet no. 394
   [Anonymous], 2015, The European mental health action plan 2013-2020
   Antonovsky A., 1987, J NERV MENT DIS, V177, P439
   Antonovsky A., 1979, HLTH STRESS COPING N
   Barbouni A., 2017, INT J CARING SCI, V10, P129
   Bengtsson-Tops A, 2001, J ADV NURS, V33, P432, DOI 10.1046/j.1365-2648.2001.01692.x
   Blomqvist M, 2018, ISSUES MENT HEALTH N, V39, P585, DOI 10.1080/01612840.2017.1422200
   Brunero S, 2010, INT J NURS STUD, V47, P753, DOI 10.1016/j.ijnurstu.2009.11.004
   Bucci S, 2015, PSYCHOL PSYCHOTHER-T, V88, P335, DOI 10.1111/papt.12042
   Buhagiar K, 2011, BMC PSYCHIATRY, V11, DOI 10.1186/1471-244X-11-104
   Burström K, 2014, QUAL LIFE RES, V23, P431, DOI 10.1007/s11136-013-0496-4
   Connolly M., 2005, ADV PSYCHIAT TREATME, V11, P125, DOI [DOI 10.1192/APT.11.2.125, 10.1192/apt.11.2.125]
   Crump C, 2013, AM J PSYCHIAT, V170, P324, DOI 10.1176/appi.ajp.2012.12050599
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   Dickerson F, 2016, SCHIZOPHR RES, V170, P177, DOI 10.1016/j.schres.2015.11.010
   Eriksson M, 2005, J EPIDEMIOL COMMUN H, V59, P460, DOI 10.1136/jech.2003.018085
   Eriksson M, 2006, J EPIDEMIOL COMMUN H, V60, P376, DOI 10.1136/jech.2005.041616
   Eriksson M, 2007, J EPIDEMIOL COMMUN H, V61, P938, DOI 10.1136/jech.2006.056028
   Eriksson M, 2007, J EPIDEMIOL COMMUN H, V61, P684, DOI 10.1136/jech.2006.047498
   Eskelinen S, 2015, NORD J PSYCHIAT, V69, P339, DOI 10.3109/08039488.2014.983544
   EuroQoL, 2015, EQ 5D 3L US GUID BAS
   Ewart SB, 2017, HEALTH EXPECT, V20, P984, DOI 10.1111/hex.12539
   Forsberg KA, 2010, J CLIN NURS, V19, P1519, DOI 10.1111/j.1365-2702.2009.03010.x
   Fusar-Poli P, 2009, PERSPECT PSYCHIATR C, V45, P87, DOI 10.1111/j.1744-6163.2009.00202.x
   Government Offices of Sweden, 2012, PRIO PSYK OH PLAN RI
   Gupta K., 2015, Indian Journal of Positive Psychology, V6, P32
   Hanse JJ, 1999, WORK STRESS, V13, P204, DOI 10.1080/026783799296020
   Happell B, 2016, J CLIN NURS, V25, P2933, DOI 10.1111/jocn.13355
   Heald A, 2017, ANN GEN PSYCHIATR, V16, DOI 10.1186/s12991-017-0134-6
   Hultsjo Sally, 2013, Open Nurs J, V7, P114, DOI 10.2174/1874434601307010114
   IBM Corp, 2012, Released 2021. IBM SPSS statistics for windows
   Janney CA, 2013, SCHIZOPHR RES, V145, P63, DOI 10.1016/j.schres.2013.01.010
   Lahti M, 2012, PSYCHOL MED, V42, P2275, DOI 10.1017/S0033291712000396
   Lassenius O, 2013, J PSYCHIATR MENT HLT, V20, P82, DOI 10.1111/j.1365-2850.2012.01951.x
   Laursen TM, 2012, CURR OPIN PSYCHIATR, V25, P83, DOI 10.1097/YCO.0b013e32835035ca
   Lindmark U, 2010, SCAND J PUBLIC HEALT, V38, P1, DOI 10.1177/1403494809351654
   Malhotra N, 2016, INDIAN J MED RES, V143, P434, DOI 10.4103/0971-5916.184284
   McDaid TM, 2015, J PSYCHIATR MENT HLT, V22, P157, DOI 10.1111/jpm.12185
   Mueser KT, 2004, LANCET, V363, P2063, DOI 10.1016/S0140-6736(04)16458-1
   Nilsen V, 2015, PUBLIC HEALTH, V129, P155, DOI 10.1016/j.puhe.2014.12.014
   Ochiai RDaitou., 2012, Health, V4, P20, DOI [10.4236/health.2012.41005, DOI 10.4236/HEALTH.2012.41005]
   Olsson MB, 2002, J INTELL DISABIL RES, V46, P548, DOI 10.1046/j.1365-2788.2002.00414.x
   Osborn DPJ, 2007, SOC PSYCH PSYCH EPID, V42, P787, DOI 10.1007/s00127-007-0247-3
   Parse R R, 1990, Nurs Sci Q, V3, P136, DOI 10.1177/089431849000300309
   Patterson S, 2010, J MENT HEALTH, V19, P532, DOI 10.3109/09638237.2010.520367
   Public Health Agency of Sweden, SWED NAT PUBL HLTH S
   Schwarz N, 1999, AM PSYCHOL, V54, P93, DOI 10.1037/0003-066X.54.2.93
   Siegrist J., 2006, Social inequalities in health: New evidence and policy implications
   Skär L, 2014, SAGE OPEN MED, V2, DOI 10.1177/2050312114546923
   Södergren M, 2008, BMC PUBLIC HEALTH, V8, DOI 10.1186/1471-2458-8-352
   Stubbs B, 2015, ACTA PSYCHIAT SCAND, V132, P144, DOI 10.1111/acps.12439
   Stubbs B, 2016, SCHIZOPHR RES, V171, P103, DOI 10.1016/j.schres.2016.01.034
   The Public Health Agency of Sweden, 2016, FOLKH
   Vancampfort D, 2012, PSYCHIAT RES, V200, P73, DOI 10.1016/j.psychres.2012.03.046
   von Lengerke T, 2007, INT J PUBLIC HEALTH, V52, P16, DOI 10.1007/s00038-006-5038-1
   Wainwright NWJ, 2007, J EPIDEMIOL COMMUN H, V61, DOI 10.1136/jech.2006.056275
   Wärdig RE, 2013, ISSUES MENT HEALTH N, V34, P602, DOI 10.3109/01612840.2013.790525
   WHO, 2014, GLOBAL STATUS REPORT ON VIOLENCE PREVENTION 2014, P1
   WILLIAMS A, 1990, HEALTH POLICY, V16, P199
   World Health Organization, 2001, AUDIT THE ALCOHOL US
   World Medical Association Declaration of Helsinki, 2015, ETH PRINC MED RES IN
   2015, PREV MED, V75, P12, DOI DOI 10.1016/J.YPMED.2015.03.007
   2017, ISSUES MENTAL HLTH N, V38, P717, DOI DOI 10.1080/01612840.2017.1330909
   2007, EUROPEAN PSYCHIAT, V22, P177, DOI DOI 10.1016/J.EURPSY.2006.08.004
NR 66
TC 10
Z9 10
U1 2
U2 14
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0883-9417
EI 1532-8228
J9 ARCH PSYCHIAT NURS
JI Arch. Psychiatr. Nurs.
PD APR
PY 2019
VL 33
IS 2
BP 182
EP 188
DI 10.1016/j.apnu.2018.12.002
PG 7
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA HW6XH
UT WOS:000466833600008
PM 30927988
DA 2025-06-11
ER

PT J
AU Misiak, B
   Kiejna, A
   Frydecka, D
AF Misiak, Blazej
   Kiejna, Andrzej
   Frydecka, Dorota
TI The history of childhood trauma is associated with lipid disturbances
   and blood pressure in adult first-episode schizophrenia patients
SO GENERAL HOSPITAL PSYCHIATRY
LA English
DT Article
DE First-episode schizophrenia; Blood pressure; Lipids; Childhood trauma;
   Early life stress
ID POSTTRAUMATIC-STRESS-DISORDER; ONE-CARBON METABOLISM; CYTOKINE
   ALTERATIONS; METAANALYSIS; PSYCHOSIS; VETERANS; DEPRESSION; EXERCISE;
   ABUSE
AB Objective: It has repeatedly been found that early-life traumatic events may contribute to metabolic dysregulation. Therefore, the aim of this study was to investigate the association between the history of childhood trauma and cardiovascular risk factors in first-episode schizophrenia (FES) patients.
   Method: The history of childhood traumawas assessed using the Early Trauma Inventory Self Report-Short Form (ETISR-SF) in 83 FES patients. Based on the ETISR-SF, patients were divided into those with positive and negative history of childhood trauma: FES(+) and FES(-) patients. Serum levels of fasting glucose lipids, homocysteine, vitamin B12 and folate, as well as anthropometric parameters and resting systolic and diastolic blood pressure (SBP and DBP) were measured.
   Results: The history of childhood trauma was associated with higher low-density lipoprotein (LDL) levels, SBP and DBP after covarying for age, gender, body mass index, education and chlorpromazine equivalent. There were significant correlations between scores of distinct ETISR-SF subscales and LDL, high-density lipoprotein, SBP, DBP and the number of metabolic syndrome criteria.
   Conclusions: Results of this study indicate that traumatic events during childhood might be related to higher resting blood pressure and higher LDL levels in adult FES patients. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Misiak, Blazej; Kiejna, Andrzej; Frydecka, Dorota] Wroclaw Med Univ, Dept Psychiat, PL-50367 Wroclaw, Poland.
   [Misiak, Blazej] Wroclaw Med Univ, Dept Genet, PL-50368 Wroclaw, Poland.
C3 Wroclaw Medical University; Wroclaw Medical University
RP Misiak, B (corresponding author), Wroclaw Med Univ, Dept Psychiat, 10 Pasteur St, PL-50367 Wroclaw, Poland.
EM mblazej@interia.eu
RI Frydecka, Dorota/ABD-8176-2021; Misiak, Błażej/ABA-2657-2021
OI Misiak, Blazej/0000-0002-5392-6398; Frydecka, Dorota/0000-0001-8582-9958
FU National Science Center [DEC-2011/03/N/NZ5/00248]; START scholarship by
   Foundation for Polish Science
FX We are deeply grateful to all patients participating in this study. This
   work was supported by the research grant awarded by National Science
   Center (decision number: DEC-2011/03/N/NZ5/00248). Blazej Misiak is
   supported by the START scholarship provided by the Foundation for Polish
   Science.
CR [Anonymous], NEUROSCI BIOBEHAV RE
   Bartoli F, 2013, METAB SYNDR RELAT D, V11, P301, DOI 10.1089/met.2013.0010
   Bonoldi I, 2013, PSYCHIAT RES, V210, P8, DOI 10.1016/j.psychres.2013.05.003
   Bremner JD, 2000, DEPRESS ANXIETY, V12, P1, DOI 10.1002/1520-6394(2000)12:1<1::AID-DA1>3.0.CO;2-W
   Buckley TC, 2001, PSYCHOSOM MED, V63, P585, DOI 10.1097/00006842-200107000-00011
   Ciufolini S, 2014, NEUROSCI BIOBEHAV R, V47, P359, DOI 10.1016/j.neubiorev.2014.09.004
   Dennison U, 2012, PSYCHOL MED, V42, P1865, DOI 10.1017/S0033291712000074
   Ehlert U, 2013, PSYCHONEUROENDOCRINO, V38, P1850, DOI 10.1016/j.psyneuen.2013.06.007
   Hasnain M, 2010, CURR DIABETES REP, V10, P209, DOI 10.1007/s11892-010-0112-8
   Hepgul N, 2012, PSYCHOL MED, V42, P1893, DOI 10.1017/S0033291711002947
   Jendricko T, 2009, PROG NEURO-PSYCHOPH, V33, P134, DOI 10.1016/j.pnpbp.2008.11.002
   Kagan BL, 1999, BIOL PSYCHIAT, V45, P374, DOI 10.1016/S0006-3223(98)00059-6
   Karlovic D, 2004, J KOREAN MED SCI, V19, P431, DOI 10.3346/jkms.2004.19.3.431
   Karlovic D, 2004, ACTA MED OKAYAMA, V58, P23
   Kibler JL, 2014, WORLD J CARDIOL, V6, P455, DOI 10.4330/wjc.v6.i6.455
   Kibler JL, 2009, BEHAV MED, V34, P125, DOI 10.3200/BMED.34.4.125-132
   Levine J, 2008, DEPRESS ANXIETY, V25, pE154, DOI 10.1002/da.20400
   Maia DB, 2008, J AFFECT DISORDERS, V107, P259, DOI 10.1016/j.jad.2007.08.013
   MCGUFFIN P, 1991, ARCH GEN PSYCHIAT, V48, P764
   Miller BJ, 2011, BIOL PSYCHIAT, V70, P663, DOI 10.1016/j.biopsych.2011.04.013
   Misiak B, 2014, EUR J CLIN PHARMACOL, V70, P1433, DOI 10.1007/s00228-014-1762-2
   Misiak B, 2014, METAB BRAIN DIS, V29, P661, DOI 10.1007/s11011-014-9534-3
   Misiak B, 2013, EPIGENOMICS-UK, V5, P317, DOI [10.2217/epi.13.22, 10.2217/EPI.13.22]
   Moustafa AA, 2014, FRONT BEHAV NEUROSCI, V8, DOI 10.3389/fnbeh.2014.00343
   Nordholm D, 2013, PSYCHONEUROENDOCRINO, V38, P2394, DOI 10.1016/j.psyneuen.2013.06.030
   Parrish C, 2013, PREV CHRONIC DIS, V10, DOI 10.5888/pcd10.130193
   Pole N, 2007, PSYCHOL BULL, V133, P725, DOI 10.1037/0033-2909.133.5.725
   Potvin S, 2008, BIOL PSYCHIAT, V63, P801, DOI 10.1016/j.biopsych.2007.09.024
   Russell VA, 2014, METAB BRAIN DIS, V29, P255, DOI 10.1007/s11011-013-9479-y
   Solter V, 2002, CROAT MED J, V43, P685
   Spann SJ, 2014, GEN HOSP PSYCHIAT, V36, P150, DOI 10.1016/j.genhosppsych.2013.10.004
   Stults-Kolehmainen MA, 2014, SPORTS MED, V44, P81, DOI 10.1007/s40279-013-0090-5
   van Venrooij JAEM, 2012, SCHIZOPHRENIA BULL, V38, P272, DOI 10.1093/schbul/sbq062
   Von Känel R, 2010, WORLD J BIOL PSYCHIA, V11, P141, DOI 10.3109/15622970903449846
NR 34
TC 24
Z9 28
U1 1
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0163-8343
EI 1873-7714
J9 GEN HOSP PSYCHIAT
JI Gen. Hosp. Psych.
PD JUL-AUG
PY 2015
VL 37
IS 4
BP 365
EP 367
DI 10.1016/j.genhosppsych.2015.03.017
PG 3
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CJ5UG
UT WOS:000355555800017
PM 25881769
DA 2025-06-11
ER

PT J
AU Fan, WX
   Huang, YL
   Zheng, H
   Li, SQ
   Li, ZH
   Yuan, L
   Cheng, X
   He, CS
   Sun, JF
AF Fan, Wenxiang
   Huang, Yongliang
   Zheng, Hui
   Li, Shuiqin
   Li, Zhuohong
   Yuan, Li
   Cheng, Xi
   He, Chengshi
   Sun, Jianfeng
TI Ginsenosides for the treatment of metabolic syndrome and cardiovascular
   diseases: Pharmacology and mechanisms
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Metabolic syndrome; Cardiovascular diseases; Ginsenosides; Signaling
   pathways; Mechanism
ID ACTIVATED PROTEIN-KINASE; NF-KAPPA-B; PANAX-NOTOGINSENG SAPONINS; ACUTE
   ISCHEMIC-STROKE; INSULIN-RESISTANCE; COMPOUND K; HYPOXIA/REOXYGENATION
   INJURY; GLUCOCORTICOID-RECEPTOR; OXIDATIVE STRESS; ADIPOSE-TISSUE
AB Epidemiological studies showed that the metabolic syndromes (MetS) and cardiovascular diseases (CVDs) are responsible for a serious threat to human health worldwide. MetS is a syndromes characterized by fat metabolism disorder, obesity, diabetes, insulin resistance and other risk factors, which increases the risk of CVDs initiation and development. Although certain drugs play a role in lowering blood sugar and lipid, some side effects also occur. Considering the multiple pathogenesis, a great deal of natural products have been attempted to treat metabolic syndromes. Ginsenosides, as the active components isolated from Panax ginseng C.A.Mey, have been reported to have therapeutic effects on MetS and CVDs, of which pharmacological mechanisms were further studied as well. This review aims to systematically summarize current pharmacological effects of ginsenosides on MetS and CVDs, potential mechanisms and clinic trials, which will greatly contribute to the development of potential agents for related disease treatment.
C1 [Fan, Wenxiang] Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, Shanghai 201203, Peoples R China.
   [Huang, Yongliang; Zheng, Hui; Li, Shuiqin; Li, Zhuohong; Yuan, Li; Cheng, Xi; He, Chengshi; Sun, Jianfeng] Hosp Chengdu Univ Tradit Chinese Med, 39 Shierqiao Rd, Chengdu 610072, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine
RP He, CS; Sun, JF (corresponding author), Hosp Chengdu Univ Tradit Chinese Med, 39 Shierqiao Rd, Chengdu 610072, Peoples R China.
EM hechengshicdutcm@163.com; sunjianfeng731@163.com
FU National Natural Science Foundation of China [81503254]; Research
   Promotion Plan for Xinglin Scholars in Chengdu University of Traditional
   Chinese Medicine [QNXZ2019018]; Science and technology development fund
   project of Hospital of Chengdu University of traditional Chinese
   Medicine [Y2019128, Y2018006, Y2019114]
FX This research was funded by National Natural Science Foundation of China
   (no.81503254); Research Promotion Plan for Xinglin Scholars in Chengdu
   University of Traditional Chinese Medicine (no. QNXZ2019018); Science
   and technology development fund project of Hospital of Chengdu
   University of traditional Chinese Medicine (no. Y2019128); Science and
   technology development fund project of Hospital of Chengdu University of
   traditional Chinese Medicine (no. Y2018006); Science and technology
   development fund project of Hospital of Chengdu University of
   traditional Chinese Medicine (no. Y2019114).
CR Ahn Sungeun, 2017, MED CHEM RES INT J R
   Alolga RN, 2020, PHARMACOL RES, V152, DOI 10.1016/j.phrs.2020.104630
   Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
   Amgalan D, 2019, NATURE, V568, P324, DOI 10.1038/d41586-019-00983-4
   Anghel SI, 2007, CELL RES, V17, P486, DOI 10.1038/cr.2007.48
   [Anonymous], 2015, DIABETES CARE, V38, pS1, DOI 10.2337/dc15-S001
   [Anonymous], 2023, ENERG SOURCE PART A, DOI DOI 10.1080/15567036.2019.1677817
   Baggio LL, 2007, GASTROENTEROLOGY, V132, P2131, DOI 10.1053/j.gastro.2007.03.054
   Bailey CJ, 2017, DIABETOLOGIA, V60, P1566, DOI 10.1007/s00125-017-4318-z
   Baker RG, 2011, CELL METAB, V13, P11, DOI 10.1016/j.cmet.2010.12.008
   Buckley LF, 2019, AM J MED, V132, P16, DOI 10.1016/j.amjmed.2018.08.019
   Cai HA, 2019, LIFE SCI, V233, DOI 10.1016/j.lfs.2019.05.081
   Cao LJ, 2013, MOL CELL BIOCHEM, V380, P203, DOI 10.1007/s11010-013-1674-y
   Chalasani N, 2012, GASTROENTEROLOGY, V142, P1592, DOI 10.1053/j.gastro.2012.04.001
   Chan LY, 2004, REPROD TOXICOL, V19, P131, DOI 10.1016/j.reprotox.2004.06.001
   Chang WH, 2015, J INT SOC SPORT NUTR, V12, DOI 10.1186/s12970-015-0095-6
   Chen F, 2012, BIOL PHARM BULL, V35, P1568, DOI 10.1248/bpb.b12-00461
   Chen H, 2012, BMC COMPLEM ALTERN M, V12, DOI 10.1186/1472-6882-12-53
   Chen JM, 2019, EUR J PHARMACOL, V856, DOI 10.1016/j.ejphar.2019.172418
   Chen LL, 2018, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00965
   Chen W, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10030372
   Chen WJ, 2016, J GINSENG RES, V40, P351, DOI 10.1016/j.jgr.2015.11.002
   Chen X, 2019, BIOMED PHARMACOTHER, V120, DOI 10.1016/j.biopha.2019.109487
   Chen XJ, 2017, SCI REP-UK, V7, DOI 10.1038/srep41144
   Cheung N, 2010, LANCET, V376, P124, DOI 10.1016/S0140-6736(09)62124-3
   Chillarón JJ, 2014, METABOLISM, V63, P181, DOI 10.1016/j.metabol.2013.10.002
   Christodoulides C, 2010, MOL CELL ENDOCRINOL, V318, P61, DOI 10.1016/j.mce.2009.09.014
   Chu SF, 2019, ACTA PHARMACOL SIN, V40, P13, DOI 10.1038/s41401-018-0154-z
   Cnop Miriam, 2005, MECH PANCREATIC B CE
   Cui YC, 2017, SCI REP-UK, V7, DOI 10.1038/srep44579
   Dai SS, 2018, BIOMED PHARMACOTHER, V100, P93, DOI 10.1016/j.biopha.2018.01.111
   De Bosscher K, 2003, ENDOCR REV, V24, P488, DOI 10.1210/er.2002-0006
   de Sá PM, 2017, COMPR PHYSIOL, V7, P635, DOI 10.1002/cphy.c160022
   Deng JJ, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00506
   DiDonato JA, 1997, NATURE, V388, P548, DOI 10.1038/41493
   Dilshara MG, 2014, INT IMMUNOPHARMACOL, V18, P203, DOI 10.1016/j.intimp.2013.11.020
   Dong GT, 2016, MITOCHONDRION, V26, P7, DOI 10.1016/j.mito.2015.11.003
   Du J, 2011, J IMMUNOL, V187, P942, DOI 10.4049/jimmunol.1002579
   Ezzati M, 2002, LANCET, V360, P1347, DOI 10.1016/S0140-6736(02)11403-6
   Fa Xiaoming, 2018, EUR J PHARM
   Fan CL, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20194936
   Fan JS, 2016, J ETHNOPHARMACOL, V192, P423, DOI 10.1016/j.jep.2016.09.022
   Fan WX, 2019, MOLECULES, V24, DOI 10.3390/molecules24020359
   Fan XM, 2019, EUR J PHARMACOL, V854, P247, DOI 10.1016/j.ejphar.2019.04.027
   Fang HH, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-25874-y
   Feuerstein GZ, 2001, CARDIOVASC DRUG THER, V15, P547, DOI 10.1023/A:1013775906652
   Fletcher Barbara, 2002, J Cardiovasc Nurs, V16, P17
   Galic S, 2010, MOL CELL ENDOCRINOL, V316, P129, DOI 10.1016/j.mce.2009.08.018
   Gao Y, 2013, J ETHNOPHARMACOL, V147, P509, DOI 10.1016/j.jep.2013.03.057
   Garcia D, 2017, MOL CELL, V66, P789, DOI 10.1016/j.molcel.2017.05.032
   Gowans GJ, 2013, CELL METAB, V18, P556, DOI 10.1016/j.cmet.2013.08.019
   Grundy SM, 2012, J AM COLL CARDIOL, V59, P635, DOI 10.1016/j.jacc.2011.08.080
   Gu J, 2013, FITOTERAPIA, V87, P84, DOI 10.1016/j.fitote.2013.03.020
   Gu W, 2013, BIOL PHARM BULL, V36, P102, DOI 10.1248/bpb.b12-00558
   Guo MQ, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00464
   Guo MQ, 2018, J CELL MOL MED, V22, P3202, DOI 10.1111/jcmm.13601
   Gupta SC, 2010, BBA-GENE REGUL MECH, V1799, P775, DOI 10.1016/j.bbagrm.2010.05.004
   Gutiérrez E, 2013, EUR HEART J, V34, P3175, DOI 10.1093/eurheartj/eht351
   Hardie DG, 2015, CURR OPIN CELL BIOL, V33, P1, DOI 10.1016/j.ceb.2014.09.004
   Hawley SA, 2005, CELL METAB, V2, P9, DOI 10.1016/j.cmet.2005.05.009
   Hong YL, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00153
   Hu J.-N., 2017, J GINSENG RES
   Huang Q, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18051063
   Hui Z, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1579-5
   Hwang YC, 2018, KOREAN J INTERN MED, V33, P347, DOI 10.3904/kjim.2015.208
   Jayachandran M, 2020, CRIT REV FOOD SCI, V60, P2914, DOI 10.1080/10408398.2019.1666792
   Jeon SM, 2016, EXP MOL MED, V48, DOI 10.1038/emm.2016.81
   Jing X., 2018, EUR J PHARM
   Jo J, 2009, PLOS COMPUT BIOL, V5, DOI 10.1371/journal.pcbi.1000324
   Jorgensen Roberta A, 2003, Gastroenterol Nurs, V26, P150, DOI 10.1097/00001610-200307000-00003
   Jovanovski E, 2014, J AM SOC HYPERTENS, V8, P537, DOI 10.1016/j.jash.2014.04.004
   Jovanovski E, 2014, CARDIOVASC THER, V32, P163, DOI 10.1111/1755-5922.12077
   Jung UJ, 2014, INT J MOL SCI, V15, P6184, DOI 10.3390/ijms15046184
   Kawai T, 2007, TRENDS MOL MED, V13, P460, DOI 10.1016/j.molmed.2007.09.002
   Kim DY, 2010, FOOD SCI BIOTECHNOL, V19, P1277, DOI 10.1007/s10068-010-0182-z
   Kim JM, 2017, J AGR FOOD CHEM, V65, P2719, DOI 10.1021/acs.jafc.7b00297
   Kim KS, 2015, SCI REP-UK, V5, DOI 10.1038/srep18325
   Kim MJ, 2016, DIABETES METAB J, V40, P406, DOI 10.4093/dmj.2016.40.5.406
   Kim MS, 2013, LIVER INT, V33, P1583, DOI 10.1111/liv.12287
   Kim TW, 2012, INT IMMUNOPHARMACOL, V12, P110, DOI 10.1016/j.intimp.2011.10.023
   Kim YJ, 2016, ISLETS, V8, P57, DOI 10.1080/19382014.2016.1161874
   Koh EJ, 2017, J GINSENG RES, V41, P23, DOI 10.1016/j.jgr.2015.12.005
   Lee HM, 2012, PHYTOTHER RES, V26, P1017, DOI 10.1002/ptr.3686
   Lee J, 2017, IEEE ASIAN SOLID STA, P5, DOI 10.1109/ASSCC.2017.8240202
   Lee K, 2019, J GINSENG RES, V43, P589, DOI 10.1016/j.jgr.2018.07.005
   Lee KT, 2011, ARCH PHARM RES, V34, P1201, DOI 10.1007/s12272-011-0719-6
   Lee OH, 2011, PHYTOTHER RES, V25, P768, DOI 10.1002/ptr.3322
   Lee S, 2012, INT J MOL SCI, V13, P5729, DOI 10.3390/ijms13055729
   Li J, 2011, EUR J PHARMACOL, V652, P104, DOI 10.1016/j.ejphar.2010.11.017
   Li JB, 2018, BRAZ J MED BIOL RES, V51, DOI [10.1590/1414-431X20177139, 10.1590/1414-431x20177139]
   Li KK, 2015, RSC ADV, V5, P47353, DOI 10.1039/c5ra05864c
   Li L, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00078
   Li QH, 2017, CELL PHYSIOL BIOCHEM, V44, P21, DOI 10.1159/000484578
   Li Z, 2018, J GINSENG RES, V42, P1, DOI 10.1016/j.jgr.2016.12.005
   Li ZP, 2017, FOOD SCI BIOTECHNOL, V26, P767, DOI 10.1007/s10068-017-0090-6
   Lim S, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.01154
   Lin N, 2014, CELL BIOCHEM BIOPHYS, V68, P189, DOI 10.1007/s12013-013-9688-3
   Liu C, 2013, J ENDOCRINOL, V217, P185, DOI 10.1530/JOE-12-0502
   Liu HM, 2019, FOOD FUNCT, V10, P3603, DOI 10.1039/c9fo00027e
   Liu HM, 2018, NUTRIENTS, V10, DOI 10.3390/nu10070830
   Liu JJ, 2014, EXPERT OPIN INV DRUG, V23, P523, DOI 10.1517/13543784.2014.892582
   Liu LX, 2014, BIOL PHARM BULL, V37, P560, DOI 10.1248/bpb.b13-00770
   Liu QA, 2011, NEUROCHEM INT, V58, P119, DOI 10.1016/j.neuint.2010.11.004
   Liu Q, 2017, THERANOSTICS, V7, P4001, DOI 10.7150/thno.18788
   Liu X, 2012, EUR J NEUROL, V19, P855, DOI 10.1111/j.1468-1331.2011.03634.x
   liu y., 2019, FOOD FUNCT
   Liu Z., 2018, J CELL BIOCH
   Lo SH, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18071364
   Lou MD, 2019, BRIT J PHARMACOL, V176, P2962, DOI 10.1111/bph.14758
   Lu S, 2019, J GINSENG RES, V43, P95, DOI 10.1016/j.jgr.2017.09.004
   Lumeng CN, 2011, J CLIN INVEST, V121, P2111, DOI 10.1172/JCI57132
   Luo LP, 2016, J ENDOCRINOL, V231, pR77, DOI 10.1530/JOE-16-0211
   Ma LJ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0103628
   McCreight LJ, 2016, DIABETOLOGIA, V59, P426, DOI 10.1007/s00125-015-3844-9
   Meng FL, 2017, EXP THER MED, V13, P2551, DOI 10.3892/etm.2017.4280
   Meng LQ, 2019, BIOL PHARM BULL, V42, P462, DOI 10.1248/bpb.b18-00799
   Mercurio F, 1997, SCIENCE, V278, P860, DOI 10.1126/science.278.5339.860
   Mo J, 2019, PHARMACOL REP, V71, P1160, DOI 10.1016/j.pharep.2019.07.004
   Moseti D, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17010124
   Mozaffari MS, 2013, AM J CARDIOVASC DIS, V3, P180
   Mu QQ, 2015, BIOCHEM BIOPH RES CO, V466, P530, DOI 10.1016/j.bbrc.2015.09.064
   Nam HY, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00817
   Nanao-Hamai M, 2019, EUR J PHARMACOL, V859, DOI 10.1016/j.ejphar.2019.172546
   Napetschnig J, 2013, ANNU REV BIOPHYS, V42, P443, DOI 10.1146/annurev-biophys-083012-130338
   Ni HX, 2010, MOL BIOL REP, V37, P2975, DOI 10.1007/s11033-009-9864-0
   Palomer X, 2013, INT J CARDIOL, V168, P3160, DOI 10.1016/j.ijcard.2013.07.150
   Pan CS, 2012, VASC PHARMACOL, V56, P150, DOI 10.1016/j.vph.2011.12.006
   Postic C, 2008, J CLIN INVEST, V118, P829, DOI 10.1172/JCI34275
   Qi HY, 2018, MED RES REV, V38, P625, DOI 10.1002/med.21450
   Qiang L, 2012, CELL, V150, P620, DOI 10.1016/j.cell.2012.06.027
   Qin M, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00953
   Quan HY, 2012, INT J MOL MED, V29, P73, DOI 10.3892/ijmm.2011.805
   Reddy MA, 2015, DIABETOLOGIA, V58, P443, DOI 10.1007/s00125-014-3462-y
   Reeds DN, 2011, DIABETES CARE, V34, P1071, DOI 10.2337/dc10-2299
   Ru WW, 2015, DRUG DISCOV THER, V9, P23, DOI 10.5582/ddt.2015.01004
   Seale P, 2011, J CLIN INVEST, V121, P96, DOI 10.1172/JCI44271
   Seidell JC, 2015, ANN NUTR METAB, V66, P7, DOI 10.1159/000375143
   Shen L, 2013, J LIPID RES, V54, P1430, DOI 10.1194/jlr.M035907
   Shi QQ, 2019, LIFE SCI, V221, P152, DOI 10.1016/j.lfs.2019.02.021
   Shi Xiaowei, 2016, METAB BRAIN DIS
   Shi YW, 2016, MOL MED REP, V14, P4849, DOI 10.3892/mmr.2016.5821
   Shi ZY, 2019, MOLECULES, V24, DOI 10.3390/molecules24132443
   Siraj FM, 2015, J ENZYM INHIB MED CH, V30, P9, DOI 10.3109/14756366.2013.871006
   Stöger JL, 2012, ATHEROSCLEROSIS, V225, P461, DOI 10.1016/j.atherosclerosis.2012.09.013
   Su P, 2016, EUR J PHARMACOL, V770, P9, DOI 10.1016/j.ejphar.2015.11.040
   Sun B, 2013, BRIT J PHARMACOL, V168, P1758, DOI 10.1111/bph.12063
   Sun J, 2019, BIOMED PHARMACOTHER, V109, P254, DOI 10.1016/j.biopha.2018.09.002
   Sun JZ, 2013, ADV METEOROL, V2013, DOI 10.1155/2013/815910
   Tabandeh MR, 2017, J RECEPT SIG TRANSD, V37, P370, DOI 10.1080/10799893.2017.1286676
   Taylor F, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004816.pub5
   Thomas CC, 2015, MED CLIN N AM, V99, P1, DOI 10.1016/j.mcna.2014.08.015
   Uzayisenga R, 2014, PHYTOTHER RES, V28, P510, DOI 10.1002/ptr.5026
   Viollet B, 2009, ACTA PHYSIOL, V196, P81, DOI 10.1111/j.1748-1716.2009.01970.x
   Walters AM, 2012, CIRC RES, V111, P1222, DOI 10.1161/CIRCRESAHA.112.265660
   Wang C, 2001, NATURE, V412, P346, DOI 10.1038/35085597
   Wang CW, 2015, MOL PHARMACOL, V88, P1072, DOI 10.1124/mol.114.097352
   Wang H, 2018, J CELL BIOCH
   Wang M, 2017, MOL MED REP, V16, P9165, DOI 10.3892/mmr.2017.7710
   Wang QW, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/3714508
   Wang Y, 2012, HORM METAB RES, V44, P33, DOI 10.1055/s-0031-1295416
   Wang YL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0065634
   Wang YP, 2015, MOL MED REP, V11, P4518, DOI 10.3892/mmr.2015.3336
   Wang YH, 2014, BRIT J PHARMACOL, V171, P3171, DOI 10.1111/bph.12660
   Wei SN, 2015, LIFE SCI, V139, P8, DOI 10.1016/j.lfs.2015.07.032
   Wong AST, 2015, NAT PROD REP, V32, P256, DOI 10.1039/c4np00080c
   Wu JY, 2012, NEUROPHARMACOLOGY, V63, P349, DOI 10.1016/j.neuropharm.2012.04.005
   Wu SB, 2014, BBA-GEN SUBJECTS, V1840, P1331, DOI 10.1016/j.bbagen.2013.10.034
   Wu YZ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0092618
   Xia R, 2011, J BIOMED BIOTECHNOL, DOI 10.1155/2011/767930
   Xiao N, 2017, DIABETOLOGIA, V60, P1084, DOI 10.1007/s00125-017-4238-y
   Xiao Q, 2019, INT J ENDOCRINOL, V2019, DOI 10.1155/2019/7514802
   Xu LN, 2018, PHARMACOL RES, V130, P451, DOI 10.1016/j.phrs.2018.01.015
   Xu LY, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00850
   Xu XF, 2017, INFLAMMOPHARMACOLOGY, V25, P33, DOI 10.1007/s10787-016-0296-x
   Xu ZM, 2019, J CELL BIOCHEM, V120, P18388, DOI 10.1002/jcb.29150
   Yang JW, 2015, MOLECULES, V20, P1293, DOI 10.3390/molecules20011293
   Yang NQ, 2012, ACTA BIOCH BIOPH SIN, V44, P999, DOI 10.1093/abbs/gms092
   Yang P, 2018, ACTA BIOCH BIOPH SIN, V50, P144, DOI 10.1093/abbs/gmx136
   Yashu X., 2018, BIOL PHARM B
   Ye RD, 2011, NEUROTHERAPEUTICS, V8, P515, DOI 10.1007/s13311-011-0051-3
   Ye RD, 2011, NEUROPHARMACOLOGY, V61, P815, DOI 10.1016/j.neuropharm.2011.05.029
   Ying Y, 2019, J AGR FOOD CHEM, V67, P8348, DOI 10.1021/acs.jafc.9b02954
   Yu HT, 2016, J CELL MOL MED, V20, P623, DOI 10.1111/jcmm.12739
   Yu HF, 2017, BIOCHEM ENG J, V125, P1, DOI 10.1016/j.bej.2017.05.010
   Yu JX, 2016, ENVIRON TOXICOL PHAR, V44, P93, DOI 10.1016/j.etap.2016.04.013
   Yu XZ, 2015, J GINSENG RES, V39, P199, DOI 10.1016/j.jgr.2014.11.004
   Yu YL, 2016, SCI REP-UK, V6, DOI 10.1038/srep21730
   Yuan HD, 2012, CHEM-BIOL INTERACT, V195, P35, DOI 10.1016/j.cbi.2011.10.006
   Zhang B, 2019, MOLECULES, V24, DOI 10.3390/molecules24020247
   Zhang B, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01227
   Zhang EY, 2017, EXP MOL MED, V49, DOI 10.1038/emm.2017.151
   Zhang GY, 2016, MOL NEUROBIOL, V53, P2529, DOI 10.1007/s12035-015-9261-8
   Zhang KM, 2011, J CELL BIOCHEM, V112, P488, DOI 10.1002/jcb.22936
   Zhang LP, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/6967853
   Zhang LY, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00113
   Zhang W, 2019, CELL DEATH DIS, V10, P1
   Zhang X, 2018, J CELL MOL MED, V22, P409, DOI 10.1111/jcmm.13329
   Zhang ZL, 2012, MOL CELL BIOCHEM, V365, P243, DOI 10.1007/s11010-012-1265-3
   Zheng X, 2017, EXP ANIM TOKYO, V66, P217, DOI 10.1538/expanim.16-0121
   Zhong L, 2015, MOL MED REP, V12, P119, DOI 10.3892/mmr.2015.3394
   Zhou P, 2018, MOLECULES, V23, DOI 10.3390/molecules23112912
   Zhou P, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00464
NR 202
TC 132
Z9 143
U1 10
U2 99
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD DEC
PY 2020
VL 132
AR 110915
DI 10.1016/j.biopha.2020.110915
PG 19
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA OX6WU
UT WOS:000593703200006
PM 33254433
OA gold
DA 2025-06-11
ER

PT J
AU Kachur, S
   Morera, R
   De Schutter, A
   Lavie, CJ
AF Kachur, Sergey
   Morera, Rebecca
   De Schutter, Alban
   Lavie, Carl J.
TI Cardiovascular Risk in Patients with Prehypertension and the Metabolic
   Syndrome
SO CURRENT HYPERTENSION REPORTS
LA English
DT Review
DE Metabolic syndrome; Obesity; Prehypertension; Heart failure; Insulin
   resistance
ID CIRCULATING OXIDIZED LDL; BODY-MASS INDEX; ENDOTHELIAL DYSFUNCTION;
   INSULIN-RESISTANCE; LONG-TERM; DIABETES-MELLITUS; OXIDATIVE STRESS;
   BLOOD-PRESSURE; HEART-FAILURE; WEIGHT-LOSS
AB Prehypertension (pHTN) andmetabolic syndrome (MetS) are both lifestyle diseases that are potentiated by increased adiposity, as both disease processes are closely related to weight. In the case of pHTN, increased adiposity causes dysregulation of the renin-angiotensin-aldosterone-system (RAAS) as well as adipokine-and leptin-associated increases in adrenergic tone. In MetS, excess weight potentiates hyperglycemia and insulin resistance which causes positive feedback into the RAAS system, activates an inflammatory cascade that potentiates atherosclerosis, and causes lipid dysregulation which together contribute to cardiovascular disease, especially coronary heart disease (CHD) and heart failure (HF). The relationship with all-cause mortality is not as clear-cut in part because of some protective effects associated with the obesity paradox in chronic diseases such as CHD and HF. However, in healthy populations, the absence of excess weight and its associated effects on prehypertension and MetS are associated with a longer absolute and disease-free lifespan.
C1 [Kachur, Sergey; Morera, Rebecca] Ocala Reg Med Ctr, Dept Grad Med Educ, 1431 SW 1st Ave, Ocala, FL 34471 USA.
   [De Schutter, Alban] NYU, Sch Med, New York, NY USA.
   [Lavie, Carl J.] Univ Queensland, Sch Med, Dept Cardiovasc Dis, Ochsner Clin Sch,John Ochsner Heart & Vasc Inst, New Orleans, LA USA.
C3 New York University; University of Queensland; Ochsner Health System
RP Kachur, S (corresponding author), Ocala Reg Med Ctr, Dept Grad Med Educ, 1431 SW 1st Ave, Ocala, FL 34471 USA.
EM Sergey.kachur@gmail.com
RI Lavie, Carl/A-6014-2011
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Ahmad FS, 2016, JACC-HEART FAIL, V4, P911, DOI 10.1016/j.jchf.2016.08.001
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Alpert MA, 2014, PROG CARDIOVASC DIS, V56, P391, DOI 10.1016/j.pcad.2013.09.003
   Balkau B, 2002, DIABETES METAB, V28, P364
   Bastien M, 2014, PROG CARDIOVASC DIS, V56, P369, DOI 10.1016/j.pcad.2013.10.016
   Bell BB, 2016, CURR OBES REP, V5, P397, DOI 10.1007/s13679-016-0231-x
   Bozkurt B, 2016, CIRCULATION, V134, pE535, DOI 10.1161/CIR.0000000000000450
   Brion MA, 2007, J HUM HYPERTENS
   Caballero AE, 2003, OBES RES, V11, P1278, DOI 10.1038/oby.2003.174
   Cassaglia PA, 2011, J PHYSIOL-LONDON, V589, P1643, DOI 10.1113/jphysiol.2011.205575
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   Davignon J, 2004, CIRCULATION, V109, P27, DOI 10.1161/01.CIR.0000131515.03336.f8
   de las Fuentes L, 2007, EUR HEART J, V28, P553, DOI 10.1093/eurheartj/ehl526
   Despres JP., 2004, HDB OBESITY ETIOLOGY, V2nd, P845
   Doehner W, 2010, EUR HEART J, V31, P146, DOI 10.1093/eurheartj/ehp339
   Du Y, 2016, J TRANSL MED, P14
   Einhorn Daniel, 2003, Endocr Pract, V9, P237
   Ervin R Bethene, 2009, Natl Health Stat Report, P1
   Esler M, 2001, AM J HYPERTENS, V14, p304S, DOI 10.1016/S0895-7061(01)02236-1
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Gelber RP, 2007, AM J HYPERTENS, V20, P370, DOI 10.1016/j.amjhyper.2006.10.011
   Glasser SP, 2014, AM J HYPERTENS, V27, P245, DOI 10.1093/ajh/hpt200
   Gropler RJ, 2012, JACC-CARDIOVASC IMAG, V5, P816, DOI 10.1016/j.jcmg.2012.07.001
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Guo XF, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061796
   Hall J E, 2000, Curr Hypertens Rep, V2, P139, DOI 10.1007/s11906-000-0073-4
   Hall JE, 2001, AM J HYPERTENS, V14, p103S, DOI 10.1016/S0895-7061(01)02077-5
   Hansson GK, 2005, NEW ENGL J MED, V352, P1685, DOI 10.1056/NEJMra043430
   Haynes W G, 2000, Curr Hypertens Rep, V2, P311, DOI 10.1007/s11906-000-0015-1
   Hernandez-Pando R, 2000, IMMUNOLOGY, V100, P352, DOI 10.1046/j.1365-2567.2000.00025.x
   Holvoet P, 2004, DIABETES, V53, P1068, DOI 10.2337/diabetes.53.4.1068
   Holvoet P, 2001, ARTERIOSCL THROM VAS, V21, P844, DOI 10.1161/01.ATV.21.5.844
   Hu G, 2004, EUR HEART J, V25, P2212, DOI 10.1016/j.ehj.2004.10.020
   Huang Y, 2013, BMC MED, P11
   Huang YL, 2015, J AM HEART ASSOC, V4, DOI 10.1161/JAHA.114.001519
   Huang YL, 2014, NEUROLOGY, V82, P1153, DOI 10.1212/WNL.0000000000000268
   Huang YL, 2014, AM HEART J, V167, P160, DOI 10.1016/j.ahj.2013.10.023
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jiménez MC, 2016, AM J HYPERTENS, V29, P1117, DOI 10.1093/ajh/hpw050
   Kachur S, 2017, MINERVA MED, V108, P212, DOI 10.23736/S0026-4806.17.05022-4
   Kalupahana NS, 2012, CRIT REV BIOCHEM MOL, V47, P379, DOI 10.3109/10409238.2012.694843
   Karasu Cimen, 2010, Open Cardiovasc Med J, V4, P240, DOI 10.2174/1874192401004010240
   Kelly RK, 2015, ADOLESC HEALTH MED T, V6, P171, DOI 10.2147/AHMT.S55837
   KU CS, 1994, AM J CARDIOL, V73, P613, DOI 10.1016/0002-9149(94)90347-6
   Lakshmi SVV, 2009, INDIAN J BIOCHEM BIO, V46, P421
   Lee Sewon, 2011, Am J Biomed Sci, V3, P241
   Lee S, 2011, AM J PHYSIOL-HEART C, V301, pH306, DOI 10.1152/ajpheart.01306.2010
   Lee S, 2011, WORLD J CARDIOL, V3, P18, DOI 10.4330/wjc.v3.i1.18
   Leiba A, 2017, J HYPERTENS, V35, P1290, DOI 10.1097/HJH.0000000000001295
   Lewington S, 2002, LANCET, V360, P1903, DOI 10.1016/S0140-6736(02)11911-8
   Li P, 2017, POSTGRAD MED, V129, P224, DOI 10.1080/00325481.2017.1268903
   Libby P, 2009, J AM COLL CARDIOL, V54, P2129, DOI 10.1016/j.jacc.2009.09.009
   Lumeng CN, 2007, J CLIN INVEST, V117, P175, DOI 10.1172/JCI29881
   Mancia G, 2014, BLOOD PRESSURE, V23, P3, DOI 10.3109/08037051.2014.868629
   McArdle MA, 2013, Front Endocrinol (Lausanne), P4, DOI DOI 10.3389/FEND0.2013.00052/ABSTRACT
   Moore LL, 2005, ARCH INTERN MED, V165, P1298, DOI 10.1001/archinte.165.11.1298
   Norris AL, 2011, OBESITY, V19, P1415, DOI 10.1038/oby.2011.21
   OISHI K, 1990, J BIOL CHEM, V265, P70
   Ortega FB, 2016, CIRC RES, V118, P1752, DOI 10.1161/CIRCRESAHA.115.306883
   Pepine CJ, 2007, CLIN CARDIOL, V30, pI4, DOI 10.1002/clc.20048
   Romero-Corral A, 2006, LANCET, V368, P666, DOI 10.1016/S0140-6736(06)69251-9
   Samuel VT, 2016, J CLIN INVEST, V126, P12, DOI 10.1172/JCI77812
   Schächinger V, 2000, CIRCULATION, V101, P1899, DOI 10.1161/01.CIR.101.16.1899
   Solymoss BC, 2009, CORONARY ARTERY DIS, V20, P1, DOI 10.1097/MCA.0b013e32831624a5
   Song GH, 2016, SCI REP-UK, V6, DOI 10.1038/srep30889
   STEPNIAKOWSKI KT, 1995, HYPERTENSION, V25, P774, DOI 10.1161/01.HYP.25.4.774
   Tabas I, 2007, CIRCULATION, V116, P1832, DOI 10.1161/CIRCULATIONAHA.106.676890
   TADDEI S, 1995, HYPERTENSION, V25, P595, DOI 10.1161/01.HYP.25.4.595
   TSAO PS, 1990, CIRCULATION, V82, P1402, DOI 10.1161/01.CIR.82.4.1402
   de Voorde J, 2013, METABOLISM, V62, P1513, DOI 10.1016/j.metabol.2013.06.004
   Vasan Ramachandran S., 2001, New England Journal of Medicine, V345, P1291, DOI 10.1056/NEJMoa003417
   Visser M, 1999, JAMA-J AM MED ASSOC, V282, P2131, DOI 10.1001/jama.282.22.2131
   Wilson PWF, 2002, ARCH INTERN MED, V162, P1867, DOI 10.1001/archinte.162.16.1867
   Yang JY, 2009, AM J PHYSIOL-HEART C, V297, pH1208, DOI 10.1152/ajpheart.00396.2009
   Zhang Hanrui, 2009, Am J Biomed Sci, V1, P133
   ,, 2015, New England Journal of Medicine, V373, P2103, DOI 10.1056/NEJMoa1511939
NR 79
TC 30
Z9 38
U1 0
U2 13
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD FEB
PY 2018
VL 20
IS 2
AR 15
DI 10.1007/s11906-018-0801-2
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GA5SC
UT WOS:000428392900007
PM 29511907
DA 2025-06-11
ER

PT J
AU Tessari, P
   Coracina, A
   Cosma, A
   Tiengo, A
AF Tessari, P.
   Coracina, A.
   Cosma, A.
   Tiengo, A.
TI Hepatic lipid metabolism and non-alcoholic fatty liver disease
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Review
DE Fatty liver; Insulin; Metabolic syndrome; Hepatic lipid; metabolism;
   Microsome; Peroxidation; Gene expression; Lipoprotein export; Metformin;
   Apoptosis
ID ACTIVATED PROTEIN-KINASE; LOW-DENSITY LIPOPROTEIN; ACETYL-COA
   CARBOXYLASE; DE-NOVO LIPOGENESIS; INSULIN-RESISTANCE; SKELETAL-MUSCLE;
   IN-VIVO; ACID OXIDATION; TRANSCRIPTION FACTOR; GENE-EXPRESSION
AB Non-alcoholic fatty liver disease (NAFLD) is an increasingly recognized pathology with a high prevalence and a possible evolution to its inflammatory counterpart (non-alcoholic steatohepatitis, or NASH). The pathophysiology of NAFLD and NASH has many links with the metabolic syndrome, sharing a causative factor in insulin resistance. According to a two-hit hypothesis, increased intrahepatic triglyceride accumulation (due to increased synthesis, decreased export, or both) is followed by a second step (or "hit"), which may lead to NASH. The tatter likely involves oxidative stress, cytochrome P450 activation, lipid peroxidation, increased inflammatory cytokine production, activation of hepatic stellate cells and apoptosis. However, both "hits" may be caused by the same factors. The aim of this article is to overview the biochemical steps of fat regulation in the liver and the alterations occurring in the pathogenesis of NAFLD and NASH. (c) 2009 Elsevier B.V. All rights reserved.
C1 [Tessari, P.; Coracina, A.; Cosma, A.; Tiengo, A.] Univ Padua, Chair Metab, Dept Clin & Expt Med, I-35100 Padua, Italy.
C3 University of Padua
RP Tessari, P (corresponding author), Univ Padua Polyclin, Chair Metab, Dept Clin & Expt Med, Via Giustiniani 2, I-35128 Padua, Italy.
EM paolo.tessari@unipd.it
OI Tessari, Paolo/0000-0002-4570-9238
FU University of Padova; PhD program of "Fondazione Cassa di Risparmio di
   Padova e Rovigo", Italy
FX Grants: This study was supported by Research Grants of the University of
   Padova (years 2006-2007) and from a PhD program of "Fondazione Cassa di
   Risparmio di Padova e Rovigo", Italy.
CR Adiels M, 2006, DIABETOLOGIA, V49, P755, DOI 10.1007/s00125-005-0125-z
   Angulo P, 2002, NEW ENGL J MED, V346, P1221, DOI 10.1038/nrdp.2015.80
   Angulo P, 2007, NUTR REV, V65, pS57, DOI [10.1111/j.1753-4887.2007.tb00329.x, 10.1301/nr.2007.jun.S57-S63]
   Assifi MM, 2005, AM J PHYSIOL-ENDOC M, V289, pE794, DOI 10.1152/ajpendo.00144.2005
   Bahcecioglu IH, 2005, HEPATO-GASTROENTEROL, V52, P1549
   Barazzoni R, 2005, AM J PHYSIOL-ENDOC M, V288, pE228, DOI 10.1152/ajpendo.00115.2004
   Barazzoni R, 2007, OBESITY, V15, P2614, DOI 10.1038/oby.2007.313
   Barazzoni R, 2007, J CLIN ENDOCR METAB, V92, P3935, DOI 10.1210/jc.2006-2527
   Barazzoni R, 2006, AM J PHYSIOL-ENDOC M, V291, pE428, DOI 10.1152/ajpendo.00225.2006
   Bellentani S, 2008, HEPATOLOGY, V47, P746, DOI 10.1002/hep.22009
   Berson A, 1998, GASTROENTEROLOGY, V114, P764, DOI 10.1016/S0016-5085(98)70590-6
   Bokarewa M, 2005, J IMMUNOL, V174, P5789, DOI 10.4049/jimmunol.174.9.5789
   Browning JD, 2004, J CLIN INVEST, V114, P147, DOI 10.1172/JCI200422422
   Browning JD, 2006, HEPATOLOGY, V44, P466, DOI 10.1002/hep.21248
   Cassader M, 2001, LIPIDS, V36, P1117, DOI 10.1007/s11745-001-0822-5
   Castro IA, 2005, AM J CLIN NUTR, V82, P32, DOI 10.1093/ajcn/82.1.32
   Cave M, 2007, J NUTR BIOCHEM, V18, P184, DOI 10.1016/j.jnutbio.2006.12.006
   Charlton N, 2002, HEPATOLOGY, V35, P898, DOI 10.1053/jhep.2002.32527
   Chavin KD, 1999, J BIOL CHEM, V274, P5692, DOI 10.1074/jbc.274.9.5692
   Chitturi S, 2002, HEPATOLOGY, V36, P403, DOI 10.1053/jhep.2002.34738
   Chitturi S, 2001, SEMIN LIVER DIS, V21, P27, DOI 10.1055/s-2001-12927
   Chitturi Shivakumar, 2002, Hepatology, V36, P1307
   Collier CA, 2006, AM J PHYSIOL-ENDOC M, V291, pE182, DOI 10.1152/ajpendo.00272.2005
   Cortez-Pinto H, 2006, CLIN NUTR, V25, P816, DOI 10.1016/j.clnu.2006.01.027
   CORTON JM, 1995, EUR J BIOCHEM, V229, P558, DOI 10.1111/j.1432-1033.1995.tb20498.x
   Dentin R, 2005, J CLIN INVEST, V115, P2843, DOI 10.1172/JCI25256
   Dixon JB, 2001, GASTROENTEROLOGY, V121, P91, DOI 10.1053/gast.2001.25540
   Fan CY, 1998, J BIOL CHEM, V273, P15639, DOI 10.1074/jbc.273.25.15639
   Feldstein AE, 2006, AM J PHYSIOL-GASTR L, V290, pG1339, DOI 10.1152/ajpgi.00509.2005
   Fishman S, 2007, FASEB J, V21, P53, DOI 10.1096/fj.06-6557com
   Foufelle F, 2002, BIOCHEM J, V366, P377, DOI 10.1042/BJ20020430
   Fryer LGD, 2002, J BIOL CHEM, V277, P25226, DOI 10.1074/jbc.M202489200
   Galli A, 2002, GASTROENTEROLOGY, V122, P1924, DOI 10.1053/gast.2002.33666
   GARCIARUIZ C, 1995, MOL PHARMACOL, V48, P825
   Gastaldelli A, 2007, GASTROENTEROLOGY, V133, P496, DOI 10.1053/j.gastro.2007.04.068
   Gibbons GF, 2004, BIOCHEM SOC T, V32, P59, DOI 10.1042/BST0320059
   Gilham D, 2005, BBA-MOL CELL BIOL L, V1736, P189, DOI 10.1016/j.bbalip.2005.08.013
   Gilham D, 2003, FASEB J, V17, P1685, DOI 10.1096/fj.02-0728fje
   Ginsberg HN, 2005, ARCH MED RES, V36, P232, DOI 10.1016/j.arcmed.2005.01.005
   Greco D, 2008, AM J PHYSIOL-GASTR L, V294, pG1281, DOI 10.1152/ajpgi.00074.2008
   GUZMAN M, 1995, BIOCHEM J, V311, P853, DOI 10.1042/bj3110853
   Hardie DG, 2004, J CELL SCI, V117, P5479, DOI 10.1242/jcs.01540
   Hellerstein MK, 1996, ANNU REV NUTR, V16, P523, DOI 10.1146/annurev.nu.16.070196.002515
   Higgins SC, 2007, ANN MED, V39, P116, DOI 10.1080/07853890601149179
   Hui JM, 2004, HEPATOLOGY, V40, P46, DOI 10.1002/hep.20280
   Hutber CA, 1997, AM J PHYSIOL-ENDOC M, V272, pE262, DOI 10.1152/ajpendo.1997.272.2.E262
   Ikejima K, 2005, HEPATOL RES, V33, P151, DOI 10.1016/j.hepres.2005.09.024
   James OFW, 1998, J HEPATOL, V29, P495, DOI 10.1016/S0168-8278(98)80073-1
   Julius U, 2003, EXP CLIN ENDOCR DIAB, V111, P246, DOI 10.1055/s-2003-41284
   JUNGERMANN K, 1989, PHYSIOL REV, V69, P708, DOI 10.1152/physrev.1989.69.3.708
   Kang HL, 2006, AM J GASTROENTEROL, V101, P2247, DOI 10.1111/j.1572-0241.2006.00719.x
   Kaser S, 2005, GUT, V54, P117, DOI 10.1136/gut.2003.037010
   Kersten S, 1999, J CLIN INVEST, V103, P1489, DOI 10.1172/JCI6223
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Kolak M, 2007, DIABETES, V56, P1960, DOI 10.2337/db07-0111
   Koteish A, 2001, SEMIN LIVER DIS, V21, P89, DOI 10.1055/s-2001-12932
   Lavoie JM, 2006, CELL MOL LIFE SCI, V63, P1393, DOI 10.1007/s00018-006-6600-y
   Lee YS, 2006, DIABETES, V55, P2256, DOI 10.2337/db06-0006
   Lin HZ, 2000, NAT MED, V6, P998, DOI 10.1038/79697
   LINKSNAGAO K, 2008, LIPIDS HLTH DIS, V7, P8
   Linn T, 1996, J CLIN ENDOCR METAB, V81, P3938, DOI 10.1210/jc.81.11.3938
   Loria P, 2007, NUTR METAB CARDIOVAS, V17, P684, DOI 10.1016/j.numecd.2007.01.007
   Lydatakis H, 2006, LIVER INT, V26, P864, DOI 10.1111/j.1478-3231.2006.01312.x
   Marchesini G, 2005, CURR OPIN LIPIDOL, V16, P421, DOI 10.1097/01.mol.0000174153.53683.f2
   Marchesini G, 2003, J CLIN ENDOCR METAB, V88, P5674, DOI 10.1210/jc.2003-031094
   Mitsuyoshi Hironori, 2006, Nihon Rinsho, V64, P1077
   Moscatiello S, 2007, NUTR METAB CARDIOVAS, V17, P63, DOI 10.1016/j.numecd.2006.08.004
   Muse ED, 2004, J CLIN INVEST, V114, P232, DOI 10.1172/JCI200421270
   Musso G, 2005, HEPATOLOGY, V42, P1175, DOI 10.1002/hep.20896
   Musso G, 2003, HEPATOLOGY, V37, P909, DOI 10.1053/jhep.2003.50132
   Nobili V, 2006, EUR J ENDOCRINOL, V155, P735, DOI 10.1530/eje.1.02288
   NOSADINI R, 1979, HORM METAB RES, V11, P661, DOI 10.1055/s-0028-1092794
   OMAGARI K, 2008, DIG DIS SCI     0509
   Oz HS, 2008, DIGEST DIS SCI, V53, P767, DOI 10.1007/s10620-007-9900-7
   Pagano C, 2006, J CLIN ENDOCR METAB, V91, P1081, DOI 10.1210/jc.2005-1056
   Pagano C, 2005, EUR J ENDOCRINOL, V152, P113, DOI 10.1530/eje.1.01821
   Pan MH, 2004, J CLIN INVEST, V113, P1277, DOI 10.1172/JCI200419197
   Pencek RR, 2005, DIABETES, V54, P355, DOI 10.2337/diabetes.54.2.355
   Peralta C, 2000, AM J PHYSIOL-GASTR L, V279, pG163, DOI 10.1152/ajpgi.2000.279.1.G163
   Pérez-Carreras M, 2003, HEPATOLOGY, V38, P999, DOI 10.1053/jhep.2003.50398
   Perseghin G, 2006, J CLIN ENDOCR METAB, V91, P5122, DOI 10.1210/jc.2006-1368
   Pietiläinen KH, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000218
   Pittas AG, 2004, J CLIN ENDOCR METAB, V89, P447, DOI 10.1210/jc.2003-031005
   Rajala MW, 2003, ENDOCRINOLOGY, V144, P3765, DOI 10.1210/en.2003-0580
   Reddy JK, 2006, AM J PHYSIOL-GASTR L, V290, pG852, DOI 10.1152/ajpgi.00521.2005
   Romero JR, 1999, LIPIDS, V34, P907, DOI 10.1007/s11745-999-0439-8
   Ruderman NB, 1999, AM J PHYSIOL-ENDOC M, V276, pE1, DOI 10.1152/ajpendo.1999.276.1.E1
   Saha AK, 2004, BIOCHEM BIOPH RES CO, V314, P580, DOI 10.1016/j.bbrc.2003.12.120
   Sakugawa H, 2005, WORLD J GASTROENTERO, V11, P255, DOI 10.3748/wjg.v11.i2.255
   Sanyal AJ, 2001, GASTROENTEROLOGY, V120, P1183, DOI 10.1053/gast.2001.23256
   Schäffler A, 2005, NAT CLIN PRACT GASTR, V2, P273, DOI 10.1038/ncpgasthep0186
   Seki S, 2002, J HEPATOL, V37, P56, DOI 10.1016/S0168-8278(02)00073-9
   Shimada M, 2007, AM J GASTROENTEROL, V102, P1931, DOI 10.1111/j.1572-0241.2007.01322.x
   Shimomura I, 1999, J BIOL CHEM, V274, P30028, DOI 10.1074/jbc.274.42.30028
   Solga S, 2004, DIGEST DIS SCI, V49, P1578, DOI 10.1023/B:DDAS.0000043367.69470.b7
   Sreekumar R, 2003, HEPATOLOGY, V38, P244, DOI 10.1053/jhep.2003.50290
   Stärkel P, 2003, J HEPATOL, V39, P538, DOI 10.1016/S0168-8278(03)00360-X
   Sul HS, 1998, ANNU REV NUTR, V18, P331, DOI 10.1146/annurev.nutr.18.1.331
   Szczepaniak LS, 2005, AM J PHYSIOL-ENDOC M, V288, pE462, DOI 10.1152/ajpendo.00064.2004
   Targher G, 2006, CLIN ENDOCRINOL, V64, P679, DOI 10.1111/j.1365-2265.2006.02527.x
   TESSARI P, 1981, ACTA DIABETOL LAT, V18, P357, DOI 10.1007/BF02042820
   Tessari P, 2008, ACTA DIABETOL, V45, P143, DOI 10.1007/s00592-008-0032-0
   TIENGO A, 1980, CURRENT VIEWS HYPOGL, P151
   Tilg H, 2006, GASTROENTEROLOGY, V131, P934, DOI 10.1053/j.gastro.2006.05.054
   Tomita K, 2005, ALCOHOL CLIN EXP RES, V29, p240S, DOI 10.1097/01.alc.0000191126.11479.69
   TONSGARD JH, 1985, J CLIN INVEST, V76, P816, DOI 10.1172/JCI112039
   TRUMBLE GE, 1995, EUR J BIOCHEM, V231, P192, DOI 10.1111/j.1432-1033.1995.tb20686.x
   Tsochatzis E, 2006, AM J GASTROENTEROL, V101, P2915
   Unger RH, 2001, FASEB J, V15, P312, DOI 10.1096/fj.00-0590
   Uotani S, 2006, BIOCHEM BIOPH RES CO, V351, P171, DOI 10.1016/j.bbrc.2006.10.015
   Viollet B, 2006, J PHYSIOL-LONDON, V574, P41, DOI 10.1113/jphysiol.2006.108506
   Watt MJ, 2006, NAT MED, V12, P541, DOI 10.1038/nm1383
   Wei YR, 2006, AM J PHYSIOL-ENDOC M, V291, pE275, DOI 10.1152/ajpendo.00644.2005
   Wiegman CH, 2003, DIABETES, V52, P1081, DOI 10.2337/diabetes.52.5.1081
   Wijendran V, 2004, ANNU REV NUTR, V24, P597, DOI 10.1146/annurev.nutr.24.012003.132106
   Winder WW, 1996, AM J PHYSIOL-ENDOC M, V270, pE299, DOI 10.1152/ajpendo.1996.270.2.E299
   Xu AM, 2003, J CLIN INVEST, V112, P91, DOI 10.1172/JCI200317797
   Yalniz M, 2006, MEDIAT INFLAMM, V2006, DOI 10.1155/MI/2006/34295
   Yamaguchi K, 2008, HEPATOLOGY, V47, P625, DOI 10.1002/hep.21988
   Yamashita H, 2001, P NATL ACAD SCI USA, V98, P9116, DOI 10.1073/pnas.161284298
   Yamauchi T, 2002, NAT MED, V8, P1288, DOI 10.1038/nm788
   Yang LY, 1996, J LIPID RES, V37, P262
   Yki-Järvinen H, 2005, ANN MED, V37, P347, DOI 10.1080/07853890510037383
   You M, 2004, GASTROENTEROLOGY, V127, P1798, DOI 10.1053/j.gastro.2004.09.049
   Youssef Wael, 2002, Semin Gastrointest Dis, V13, P17
   Zelber-Sagil S, 2007, J HEPATOL, V47, P711, DOI 10.1016/j.jhep.2007.06.020
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI13505
NR 127
TC 255
Z9 299
U1 3
U2 55
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD MAY
PY 2009
VL 19
IS 4
BP 291
EP 302
DI 10.1016/j.numecd.2008.12.015
PG 12
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 459WA
UT WOS:000267141800010
PM 19359149
DA 2025-06-11
ER

PT J
AU Fava, A
   Plastino, M
   Cristiano, D
   Spanò, A
   Cristofaro, S
   Opipari, C
   Chillà, A
   Casalinuovo, F
   Colica, C
   De Bartolo, M
   Pirritano, D
   Bosco, D
AF Fava, Antonietta
   Plastino, Massimiliano
   Cristiano, Dario
   Spano, Antonio
   Cristofaro, Stefano
   Opipari, Carlo
   Chilla, Antonio
   Casalinuovo, Fatima
   Colica, Carmen
   De Bartolo, Matteo
   Pirritano, Domenico
   Bosco, Domenico
TI Insulin resistance possible risk factor for cognitive impairment in
   fibromialgic patients
SO METABOLIC BRAIN DISEASE
LA English
DT Article
DE Cognitive deficits; Dementia; Diabetes mellitus; Pain syndrome; Insulin
   resistance
ID METABOLIC SYNDROME; PRIMARY FIBROMYALGIA; GLUCOSE-METABOLISM;
   DIABETES-MELLITUS; MEMORY; DEPRESSION; CRITERIA; NOREPINEPHRINE;
   DEMENTIA; OBESITY
AB To evaluate glucose metabolism and/or insulin resistance (IR) in 96 patients with Fibromyalgia (FM), associated or not to cognitive impairment. We investigated glucose metabolism in 96 FM patients. Enrolled patients were divided into two groups: 48 patients with memory deficit (group A) and 48 without memory deficit (control group). We evaluated glucose and insulin levels after a 2 h-Oral-Glucose-Tolerance-Test (2 h-OGTT) and insulin resistance (IR) by the homeostasis model assessment formula (HOMA). Body Mass Index (BMI), waist-to-hip-ratio (WHR), anxiety level, fasting plasma insulin and Non-Steroidal Anti-Inflammatory agents use were higher in patients with FM with memory impairment; while age, sex, waist circumference, education level, fasting plasma glucose, glycate hemoglobin, triglycerides, blood lipid profile, C- Reactivity-Protein (CRP), blood pressure and smoking habits were similar in both groups. Following OGTT the prevalence of glucose metabolism abnormalities was significantly higher in group A. IR was present in 79 % patients, of whom 23 % had also impaired glucose tolerance, 4 % newly diagnosed diabetes mellitus and 52 % IR only. Obesity and overweight prevailed in group A. IR, but not BMI or WHR was associated to an increased risk of memory impairment (OR = 2,6; 95 % CI: 1,22-3,7). The results of this study suggest that IR may represent a risk factor for memory impairment in fibromialgic patients.
C1 [Fava, Antonietta] Fdn UALSI, I-88100 Catanzaro, Italy.
   [Plastino, Massimiliano; Cristiano, Dario; Spano, Antonio; Cristofaro, Stefano; Opipari, Carlo; Casalinuovo, Fatima; Pirritano, Domenico; Bosco, Domenico] S Giovanni di Dio Hosp, Dept Neurosci, I-88900 Largo Bologna, Crotone, Italy.
   [Chilla, Antonio] S Giovanni di Dio Hosp, Dept Psychiat, I-88900 Crotone, Italy.
   [Colica, Carmen] CNR, I-88100 Catanzaro, Italy.
   [De Bartolo, Matteo] Hosp Rossano, Neurophysiol Unit, I-80068 Rossano, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR)
RP Bosco, D (corresponding author), S Giovanni di Dio Hosp, Dept Neurosci, I-88900 Largo Bologna, Crotone, Italy.
EM nico_bosco@libero.it
RI Bosco, Domenico/K-6806-2016; Colica, Carmela/AAY-4131-2020; pirritano,
   domenico/AAD-1971-2022
OI Bosco, Domenico/0000-0003-3453-9613
CR [Anonymous], DIABETES CARE S1
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   Bingham EM, 2002, DIABETES, V51, P3384, DOI 10.2337/diabetes.51.12.3384
   Blanchard JG, 1997, PHARMACOL BIOCHEM BE, V58, P209, DOI 10.1016/S0091-3057(97)00064-6
   Bonora E, 1998, DIABETES, V47, P1643, DOI 10.2337/diabetes.47.10.1643
   Bosco D, 2011, J CELL MOL MED, V15, P1807, DOI 10.1111/j.1582-4934.2011.01318.x
   Bosco D, 2009, J NEUROL SCI, V284, P24, DOI 10.1016/j.jns.2009.03.017
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Committee C, 2007, DIABETOLOGIA, V50, P2042, DOI 10.1007/s00125-007-0789-7
   FOLSTEIN MF, 1975, J PSYCHIAT RES, V12, P189, DOI 10.1016/0022-3956(75)90026-6
   Grace GM, 1999, J CLIN EXP NEUROPSYC, V21, P477, DOI 10.1076/jcen.21.4.477.876
   Greisen J, 2001, ANESTHESIOLOGY, V95, P578, DOI 10.1097/00000542-200109000-00007
   Jonides J., 1995, INVITATION COGNITIVE, V3, P215
   Landro NI, 1997, J PSYCHOSOM RES, V42, P297, DOI 10.1016/S0022-3999(96)00301-7
   Landsberg L, 1999, ANN NY ACAD SCI, V892, P84, DOI 10.1111/j.1749-6632.1999.tb07787.x
   LAWS A, 1993, BAILLIERE CLIN ENDOC, V7, P1063, DOI 10.1016/S0950-351X(05)80245-9
   Leavitt F, 2006, J RHEUMATOL, V33, P127
   Lee ZSK, 2001, METABOLISM, V50, P135, DOI 10.1053/meta.2001.19502
   LEZAK MD, 1995, NEUROPSYCHOLOGICAL A, P333
   LIPMAN R S, 1982, Psychopharmacology Bulletin, V18, P69
   Loevinger BL, 2007, METABOLISM, V56, P87, DOI 10.1016/j.metabol.2006.09.001
   Luchsinger JA, 2004, NEUROLOGY, V63, P1187, DOI 10.1212/01.WNL.0000140292.04932.87
   Martínez-Lavín M, 2000, SEMIN ARTHRITIS RHEU, V29, P197, DOI 10.1016/S0049-0172(00)80008-6
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   MEENAN RF, 1992, ARTHRITIS RHEUM, V35, P1, DOI 10.1002/art.1780350102
   MELZACK R, 1987, PAIN, V30, P191, DOI 10.1016/0304-3959(87)91074-8
   MERSKEY H, 1994, MONOGRAPH TASK FORCE, P45
   Okifuji A, 2009, CLIN RHEUMATOL, V28, P475, DOI 10.1007/s10067-009-1094-2
   Ott A, 1999, NEUROLOGY, V53, P1937, DOI 10.1212/WNL.53.9.1937
   Park DC, 1996, PSYCHOL AGING, V22, P137
   Pi-Sunyer FX, 2000, P NUTR SOC, V59, P505, DOI 10.1017/S0029665100000732
   Piper B F, 1998, Oncol Nurs Forum, V25, P677
   Plastino M, 2010, J NEUROL SCI, V288, P112, DOI 10.1016/j.jns.2009.09.022
   SLETVOLD H, 1995, J RHEUMATOL, V22, P137
   Suhr JA, 2003, J PSYCHOSOM RES, V55, P321, DOI 10.1016/S0022-3999(02)00628-1
   Talbot K, 2012, J CLIN INVEST, V122, P1316, DOI 10.1172/JCI59903
   Tewes U, 1991, HDB TESTANWEISUNGEN
   Tsigos C, 2004, J PSYCHOSOM RES, V57, P451
   UCHIDA I, 1988, BRIT J SURG, V75, P557, DOI 10.1002/bjs.1800750618
   Walitt B, 2008, RHEUMATOL INT, V28, P561, DOI 10.1007/s00296-007-0487-2
   Watson GS, 2006, NEUROBIOL AGING, V27, P38, DOI 10.1016/j.neurobiolaging.2004.11.011
   WOLFE F, 1995, J RHEUMATOL, V22, P151
   WOLFE F, 1990, ARTHRITIS RHEUM-US, V33, P160, DOI 10.1002/art.1780330203
   Wolfe F, 2010, ARTHRIT CARE RES, V62, P600, DOI 10.1002/acr.20140
   Xu WL, 2004, NEUROLOGY, V63, P1181, DOI 10.1212/01.WNL.0000140291.86406.D1
   Yaffe K, 2004, JAMA-J AM MED ASSOC, V292, P2237, DOI 10.1001/jama.292.18.2237
   Yanmaz MN, 2011, RHEUMATOL INT, V8, P1018
   YESAVAGE JA, 1983, J PSYCHIATR RES, V17, P37, DOI 10.1016/0022-3956(82)90033-4
   YUNUS MB, 1992, J RHEUMATOL, V19, P95
   Ziemus B, 2007, NEUROPSYCHOLOGIA, V45, P2016, DOI 10.1016/j.neuropsychologia.2007.02.012
NR 51
TC 26
Z9 27
U1 0
U2 9
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0885-7490
EI 1573-7365
J9 METAB BRAIN DIS
JI Metab. Brain Dis.
PD DEC
PY 2013
VL 28
IS 4
BP 619
EP 627
DI 10.1007/s11011-013-9421-3
PG 9
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 240OJ
UT WOS:000326106200010
PM 23892884
DA 2025-06-11
ER

PT J
AU Ertelt, A
   Barton, AK
   Schmitz, RR
   Gehlen, H
AF Ertelt, Antonia
   Barton, Ann-Kristin
   Schmitz, Robert R.
   Gehlen, Heidrun
TI Metabolic syndrome: is equine disease comparable to what we know in
   humans?
SO ENDOCRINE CONNECTIONS
LA English
DT Review
DE metabolism; obesity; diabetes; cardiovascular; inflammation
ID VISCERAL ADIPOSE-TISSUE; NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE;
   ENDOTHELIAL DYSFUNCTION; DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; BODY
   CONDITION; RISK-FACTORS; RECEPTOR; FAT
AB This review summarizes similarities and differences between the metabolic syndromes in humans and equines, concerning the anatomy, symptoms, and pathophysiological mechanisms. In particular, it discusses the structure and distribution of adipose tissue and its specific metabolic pathways. Furthermore, this article provides insights and focuses on issues concerning laminitis in horses and cardiovascular diseases in humans, as well as their overlap.
C1 [Ertelt, Antonia; Barton, Ann-Kristin; Schmitz, Robert R.; Gehlen, Heidrun] Free Univ Berlin, Equine Clin, Berlin, Germany.
C3 Free University of Berlin
RP Ertelt, A (corresponding author), Free Univ Berlin, Equine Clin, Berlin, Germany.
EM antonia.ertelt@fu-berlin.de
RI Barton, Ann Kristin/LPP-4522-2024
CR Aguirre V, 2002, J BIOL CHEM, V277, P1531, DOI 10.1074/jbc.M101521200
   Ahlqvist E, 2011, CLIN CHEM, V57, P241, DOI 10.1373/clinchem.2010.157016
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Aleksandrova Krasimira, 2013, Curr Nutr Rep, V2, P1
   Alemany M, 2013, NUTR RES, V33, P1, DOI 10.1016/j.nutres.2012.11.013
   Alemany M, 2012, HORM-INT J ENDOCRINO, V11, P272, DOI 10.14310/horm.2002.1356
   Alexander CM, 2003, DIABETES, V52, P1210, DOI 10.2337/diabetes.52.5.1210
   Alokail MS, 2013, BMC CANCER, V13, DOI 10.1186/1471-2407-13-54
   Aquilante CL, 2008, METABOLISM, V57, P494, DOI 10.1016/j.metabol.2007.11.010
   Arner P, 1998, LANCET, V351, P1301, DOI 10.1016/S0140-6736(05)79052-8
   Bailey SR, 2008, AM J VET RES, V69, P122, DOI 10.2460/ajvr.69.1.122
   BALLARD KW, 1978, MICROVASC RES, V16, P1, DOI 10.1016/0026-2862(78)90041-9
   Belknap JK, 2009, VET IMMUNOL IMMUNOP, V129, P155, DOI 10.1016/j.vetimm.2008.11.013
   BJORNTORP P, 1990, ARTERIOSCLEROSIS, V10, P493, DOI 10.1161/01.ATV.10.4.493
   BJORNTORP P, 1991, DIABETES CARE, V14, P1132, DOI 10.2337/diacare.14.12.1132
   Böhm I, 2007, ROFO-FORTSCHR RONTG, V179, P780, DOI 10.1055/s-2007-963295
   BOLINDER J, 1983, DIABETES, V32, P117, DOI 10.2337/diabetes.32.2.117
   Bonetti PO, 2003, ARTERIOSCL THROM VAS, V23, P168, DOI 10.1161/01.ATV.0000051384.43104.FC
   Burns TA, 2010, J VET INTERN MED, V24, P932, DOI 10.1111/j.1939-1676.2010.0551.x
   Cabanac M, 2001, INT J OBESITY, V25, pS7, DOI 10.1038/sj.ijo.0801904
   Caesar R, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011525
   Camus J P, 1966, Rev Rhum Mal Osteoartic, V33, P10
   Carter RA, 2009, EQUINE VET J, V41, P171, DOI 10.2746/042516408X342975
   Carter RA, 2009, VET J, V179, P204, DOI 10.1016/j.tvjl.2008.02.029
   Cartmill JA, 2003, J ANIM SCI, V81, P2311
   Cedergren MI, 2004, OBSTET GYNECOL, V103, P219, DOI 10.1097/01.AOG.0000107291.46159.00
   Celermajer DS, 1997, J AM COLL CARDIOL, V30, P325, DOI 10.1016/S0735-1097(97)00189-7
   Chaudhary DP, 2010, BIOL TRACE ELEM RES, V134, P119, DOI 10.1007/s12011-009-8465-z
   Cojocaru Manole, 2012, Maedica (Bucur), V7, P148
   Collino M, 2010, BRIT J PHARMACOL, V160, P1892, DOI 10.1111/j.1476-5381.2010.00671.x
   Crandall DL, 1997, MICROCIRCULATION-LON, V4, P211, DOI 10.3109/10739689709146786
   Cusi K, 2000, J CLIN INVEST, V105, P311, DOI 10.1172/JCI7535
   de la Monte SM, 2006, J ALZHEIMERS DIS, V9, P167
   de Laat MA, 2013, VET J, V197, P302, DOI 10.1016/j.tvjl.2012.12.026
   de Laat MA, 2012, VET J, V191, P317, DOI 10.1016/j.tvjl.2011.07.007
   de Luca C, 2008, FEBS LETT, V582, P97, DOI 10.1016/j.febslet.2007.11.057
   Devaraj S, 2004, ENDOCRIN METAB CLIN, V33, P431, DOI 10.1016/j.ecl.2004.03.008
   DJURHUUS MS, 1995, DIABETIC MED, V12, P664, DOI 10.1111/j.1464-5491.1995.tb00566.x
   Durham AE, 2009, EQUINE VET J, V41, P924, DOI 10.2746/042516409X452152
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   EDENS NK, 1993, AM J PHYSIOL, V265, pE374, DOI 10.1152/ajpendo.1993.265.3.E374
   Emanuelli B, 2001, J BIOL CHEM, V276, P47944, DOI 10.1074/jbc.M104602200
   Farrell GC, 2005, J HEPATOL, V43, P193, DOI 10.1016/j.jhep.2005.04.004
   Frank N, 2006, JAVMA-J AM VET MED A, V228, P1383, DOI 10.2460/javma.228.9.1383
   Frank N, 2010, J VET INTERN MED, V24, P467, DOI 10.1111/j.1939-1676.2010.0503.x
   Frank N., 2010, Equine internal medicine, V3rd, P1270
   Fulop T, 2006, PATHOL BIOL, V54, P375, DOI 10.1016/j.patbio.2006.07.002
   Gallagher D, 2009, AM J CLIN NUTR, V89, P807, DOI 10.3945/ajcn.2008.26955
   Gauff FC, 2014, AM J VET RES, V75, P367, DOI 10.2460/ajvr.75.4.367
   Geelen SNJ, 2001, COMP BIOCHEM PHYS B, V130, P145, DOI 10.1016/S1096-4959(01)00416-X
   Gentry LR, 2002, J ANIM SCI, V80, P2695
   Gesta S, 2007, CELL, V131, P242, DOI 10.1016/j.cell.2007.10.004
   Abellán PG, 2011, NUTR HOSP, V26, P1394, DOI [10.1590/S0212-16112011000600029, 10.3305/nh.2011.26.6.5305]
   Grant SFA, 2006, NAT GENET, V38, P320, DOI 10.1038/ng1732
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   HABERLAND ME, 1992, MONOGR HUM GENET, V14, P35
   Hamaguchi M, 2005, ANN INTERN MED, V143, P722, DOI 10.7326/0003-4819-143-10-200511150-00009
   HENNEKE DR, 1983, EQUINE VET J, V15, P371, DOI 10.1111/j.2042-3306.1983.tb01826.x
   Holbrook TC, 2012, VET IMMUNOL IMMUNOP, V145, P283, DOI 10.1016/j.vetimm.2011.11.013
   Hotamisligil GS, 2003, INT J OBESITY, V27, pS53, DOI 10.1038/sj.ijo.0802502
   HOTAMISLIGIL GS, 1994, P NATL ACAD SCI USA, V91, P4854, DOI 10.1073/pnas.91.11.4854
   Houseknecht KL, 2003, NUTR RES REV, V16, P83, DOI 10.1079/NRR200256
   Hube F, 1996, HORM METAB RES, V28, P690, DOI 10.1055/s-2007-979879
   Hung J, 2008, INT J OBESITY, V32, P772, DOI 10.1038/sj.ijo.0803793
   Item F, 2012, OBES REV, V13, P30, DOI 10.1111/j.1467-789X.2012.01035.x
   Johnson PJ, 2002, VET CLIN N AM-EQUINE, V18, P271, DOI 10.1016/S0749-0739(02)00006-8
   KAPLAN NM, 1989, ARCH INTERN MED, V149, P1514, DOI 10.1001/archinte.149.7.1514
   Kashyap Sangeeta R, 2007, Diab Vasc Dis Res, V4, P13, DOI 10.3132/dvdr.2007.001
   Katz LM, 2012, EQUINE VET J, V44, P752, DOI 10.1111/j.2042-3306.2012.00664.x
   Knowles EJ, 2012, EQUINE VET J, V44, P226, DOI 10.1111/j.2042-3306.2011.00419.x
   Koch TG, 2008, CAN VET J, V49, P1009
   Koutsari C, 2011, DIABETES, V60, P2032, DOI 10.2337/db11-0154
   Krauss RM, 2004, ENDOCRIN METAB CLIN, V33, P405, DOI 10.1016/j.ecl.2004.03.016
   Kumeda Yasuro, 2005, Clin Calcium, V15, P97
   Lamounier-Zepter V, 2006, BEST PRACT RES CL EN, V20, P355, DOI 10.1016/j.beem.2006.07.002
   LANDIN K, 1990, J INTERN MED, V227, P273, DOI 10.1111/j.1365-2796.1990.tb00157.x
   Laviola L, 2007, CURR PHARM DESIGN, V13, P663, DOI 10.2174/138161207780249146
   Leclercq IA, 2007, J HEPATOL, V47, P142, DOI 10.1016/j.jhep.2007.04.002
   Leeners B, 2006, CLIN SCI, V111, P81, DOI 10.1042/CS20060015
   Leggett CL, 2013, MAYO CLIN PROC, V88, P157, DOI 10.1016/j.mayocp.2012.09.017
   Li DY, 2013, JPEN-PARENTER ENTER, V37, P787, DOI 10.1177/0148607113481623
   Li J, 2002, AM J PHYSIOL-ENDOC M, V282, P1334
   Liebich HG, 2010, LEHRBUCH FARBATLAS P, P77
   Litwinczuk A., 2007, Fleischwirtsch. Int, V2, P111
   Lüscher TF, 2000, CIRCULATION, V102, P2434, DOI 10.1161/01.CIR.102.19.2434
   Ma X, 2013, EUR J CLIN NUTR, V67, P518, DOI 10.1038/ejcn.2013.24
   Mancia G, 2007, J HYPERTENS, V25, P909, DOI 10.1097/HJH.0b013e328048d004
   Manteiga S, 2013, WIRES SYST BIOL MED, V5, P425, DOI 10.1002/wsbm.1213
   Mazzuca MQ, 2012, BIOCHEM PHARMACOL, V84, P147, DOI 10.1016/j.bcp.2012.03.020
   Misra A, 1997, OBES RES, V5, P93, DOI 10.1002/j.1550-8528.1997.tb00648.x
   Muniyappa R, 2008, ENDOCRIN METAB CLIN, V37, P685, DOI 10.1016/j.ecl.2008.06.001
   Muniyappa R, 2007, ENDOCR REV, V28, P463, DOI 10.1210/er.2007-0006
   O'Rourke RW, 2009, INT J OBESITY, V33, P978, DOI 10.1038/ijo.2009.133
   Ohnuki T, 2013, INTERNAL MED, V52, P523, DOI 10.2169/internalmedicine.52.8858
   OSTMAN J, 1979, METABOLISM, V28, P1198, DOI 10.1016/0026-0495(79)90131-8
   Ouchi N, 2011, NAT REV IMMUNOL, V11, P85, DOI 10.1038/nri2921
   Petrovic N, 2010, J BIOL CHEM, V285, P7153, DOI 10.1074/jbc.M109.053942
   Pollitt C. C., 2004, Clinical Techniques in Equine Practice, V3, P3, DOI 10.1053/j.ctep.2004.07.001
   Rasouli N, 2008, J CLIN ENDOCR METAB, V93, pS64, DOI 10.1210/jc.2008-1613
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Saad MF, 1997, J CLIN ENDOCR METAB, V82, P579, DOI 10.1210/jc.82.2.579
   Saberi M, 2009, CELL METAB, V10, P419, DOI 10.1016/j.cmet.2009.09.006
   Santosa S, 2008, AM J PHYSIOL-ENDOC M, V295, pE531, DOI 10.1152/ajpendo.90357.2008
   Schiffrin EL., 2001, AM J HYPERTENS, V14, p83S, DOI DOI 10.1016/S0895-7061(01)02074-X
   Schwegler J., 2011, Der Mensch. Anatomie und Physiologie, V5
   Snijder MB, 2003, AM J CLIN NUTR, V77, P1192, DOI 10.1093/ajcn/77.5.1192
   Souci SW, 2008, DTSCH FORSCHUNGSANST, V7
   STEINBERG D, 1989, NEW ENGL J MED, V320, P915
   Summers SA, 2006, PROG LIPID RES, V45, P42, DOI 10.1016/j.plipres.2005.11.002
   Tankó LB, 2003, CIRCULATION, V107, P1626, DOI 10.1161/01.CIR.0000057974.74060.68
   Tchkonia T, 2007, AM J PHYSIOL-ENDOC M, V292, pE298, DOI 10.1152/ajpendo.00202.2006
   Tok D, 2013, ANATOL J CARDIOL, V13, P227, DOI 10.5152/akd.2013.068
   do Rego AT, 2014, EUR J INTERN MED, V25, P438, DOI 10.1016/j.ejim.2014.03.014
   Treiber K, 2009, VET IMMUNOL IMMUNOP, V129, P216, DOI 10.1016/j.vetimm.2008.11.004
   Tsujimoto H, 2008, SHOCK, V29, P315, DOI [10.1097/SHK.0b013e318157ee55, 10.1097/shk.0b013e318157ee55]
   Tsukumo DML, 2007, DIABETES, V56, P1986, DOI 10.2337/db06-1595
   Ueki K, 2004, P NATL ACAD SCI USA, V101, P10422, DOI 10.1073/pnas.0402511101
   Vick MM, 2006, REPROD FERT DEVELOP, V18, P609, DOI 10.1071/RD06016
   Vilà R, 2011, J STEROID BIOCHEM, V124, P99, DOI 10.1016/j.jsbmb.2011.01.017
   Vohl MC, 2004, OBES RES, V12, P1217, DOI 10.1038/oby.2004.153
   Waldén TB, 2012, AM J PHYSIOL-ENDOC M, V302, pE19, DOI 10.1152/ajpendo.00249.2011
   Waller AP, 2012, VET IMMUNOL IMMUNOP, V149, P208, DOI 10.1016/j.vetimm.2012.07.003
   Waller AP, 2011, J VET INTERN MED, V25, P315, DOI 10.1111/j.1939-1676.2010.0674.x
   Watarai T, 1999, ENDOCR J, V46, P629, DOI 10.1507/endocrj.46.629
   Yamamoto Y, 2010, OBESITY, V18, P872, DOI 10.1038/oby.2009.512
   Yaspelkis BB, 2009, AM J PHYSIOL-REG I, V296, pR1709, DOI 10.1152/ajpregu.00117.2009
   Zuk PA, 2001, TISSUE ENG, V7, P211, DOI 10.1089/107632701300062859
NR 128
TC 27
Z9 32
U1 0
U2 19
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 2049-3614
J9 ENDOCR CONNECT
JI Endocr. Connect.
PD SEP 1
PY 2014
VL 3
IS 3
BP R81
EP R93
DI 10.1530/EC-14-0038
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA V44UN
UT WOS:000209774000001
PM 24894908
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Syk, M
   Isaksson, J
   Rasmusson, AJ
   Ekselius, L
   Cunningham, JL
AF Syk, Mikaela
   Isaksson, Johan
   Rasmusson, Annica J.
   Ekselius, Lisa
   Cunningham, Janet L.
TI Neuroticism is positively associated with leptin/adiponectin ratio,
   leptin and IL-6 in young adults
SO SCIENTIFIC REPORTS
LA English
DT Article
ID SWEDISH UNIVERSITIES SCALES; PERSONALITY-TRAITS; CARDIOVASCULAR-DISEASE;
   INFLAMMATORY BIOMARKERS; METABOLIC SYNDROME; LIFE-STYLE; 5-FACTOR MODEL;
   UK HEALTH; RISK; DEPRESSION
AB High neuroticism is related to cardiovascular morbidity. Early detection of metabolic and cardiovascular risk is important in high-risk groups to enable preventive measures. The aim of this study was therefore to explore if neuroticism is associated with early biomarkers for cardiovascular and metabolic disease in young adults from a psychiatry cohort. Blood samples and self-ratings on neuroticism with the Swedish universities Scales of Personality (SSP) questionnaire were collected from 172 psychiatric outpatients and 46 healthy controls. The blood samples were analysed for plasma leptin, adiponectin, CRP, IL-6 and TNF-alpha. Associations between neuroticism and biomarkers were assessed using Spearman's correlation coefficients and generalized linear models adjusting for confounders. In the adjusted generalized linear models, neuroticism predicted the leptin/adiponectin ratio (p = 0.003), leptin (p = 0.004) and IL-6 (p = 0.001). These associations were not better explained by current major depressive disorder and/or anxiety disorder. Adiponectin, CRP and TNF-alpha were not associated with neuroticism. In conclusion, the findings suggest that high neuroticism is related to elevated levels of plasma leptin/adiponectin ratio, leptin and IL-6 in young adults. Young adults with high neuroticism may therefore benefit from preventive interventions to decrease the risk for future metabolic and cardiovascular morbidity, but more research is required to test this hypothesis.
C1 [Syk, Mikaela; Rasmusson, Annica J.; Ekselius, Lisa; Cunningham, Janet L.] Uppsala Univ, Akad Sjukhuset, Dept Neurosci, Psychiat, S-75185 Uppsala, Sweden.
   [Isaksson, Johan] Uppsala Univ, Dept Neurosci Child & Adolescent Psychiat, Uppsala, Sweden.
C3 Uppsala University; Uppsala University Hospital; Uppsala University
RP Syk, M (corresponding author), Uppsala Univ, Akad Sjukhuset, Dept Neurosci, Psychiat, S-75185 Uppsala, Sweden.
EM Mikaela.syk@neuro.uu.se
RI Cunningham, Janet/C-4719-2013
OI Isaksson, Johan/0000-0003-1033-2618; Cunningham,
   Janet/0000-0001-7876-7779
FU Marta och Nicke Nasvells stiftelse; Ekhaga foundation; Fredrik och
   Ingrid Thurings stiftelse; Stiftelsen Soderstrom-Konigska sjukhemmet;
   Uppsala University Hospital Research Fund (ALF); Bissen Brainwalk
FX This research was funded by grants from Marta och Nicke Nasvells
   stiftelse; Bissen Brainwalk; Ekhaga foundation, Fredrik och Ingrid
   Thurings stiftelse; Stiftelsen Soderstrom-Konigska sjukhemmet; Uppsala
   University Hospital Research Fund (ALF).
CR Ahima RS, 2004, PHYSIOL BEHAV, V81, P223, DOI 10.1016/j.physbeh.2004.02.014
   Allen MS, 2017, PERS INDIV DIFFER, V111, P205, DOI 10.1016/j.paid.2017.02.028
   Allen MS, 2017, HEALTH PSYCHOL, V36, P255, DOI 10.1037/hea0000429
   Almas A, 2017, BMC CARDIOVASC DISOR, V17, DOI 10.1186/s12872-017-0604-4
   Alò R, 2017, MOL NEUROBIOL, V54, P2674, DOI 10.1007/s12035-016-9847-9
   Aluoja A, 2009, NORD J PSYCHIAT, V63, P231, DOI 10.1080/08039480802571036
   Archer M, 2018, PSYCHIAT RES, V264, P31, DOI 10.1016/j.psychres.2018.03.073
   Armon G, 2013, PERS INDIV DIFFER, V54, P750, DOI 10.1016/j.paid.2012.11.035
   Asakawa A, 2003, J DIABETES COMPLICAT, V17, P105, DOI 10.1016/S1056-8727(02)00185-X
   Audira G, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19124038
   Bibbey A, 2013, INT J PSYCHOPHYSIOL, V90, P28, DOI 10.1016/j.ijpsycho.2012.10.018
   Cao B, 2018, J AFFECT DISORDERS, V238, P101, DOI 10.1016/j.jad.2018.05.008
   Capuron L, 2011, PSYCHOL MED, V41, P1517, DOI 10.1017/S0033291710001984
   Caron A, 2018, NAT REV NEUROSCI, V19, P153, DOI 10.1038/nrn.2018.7
   Carvalho AF, 2014, J PSYCHIATR RES, V59, P28, DOI 10.1016/j.jpsychires.2014.08.002
   Chapman BP, 2011, BRAIN BEHAV IMMUN, V25, P667, DOI 10.1016/j.bbi.2011.01.003
   Chapman BP, 2009, BRAIN BEHAV IMMUN, V23, P636, DOI 10.1016/j.bbi.2008.12.009
   Cooper J, 2001, BRIT J PSYCHIAT, V179, P85, DOI 10.1192/bjp.179.1.85-a
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   Cunningham JL, 2017, BMC PSYCHIATRY, V17, DOI 10.1186/s12888-017-1199-0
   Del Giudice M, 2018, BRAIN BEHAV IMMUN, V70, P61, DOI 10.1016/j.bbi.2018.02.013
   Dortland AKBV, 2012, PROG NEURO-PSYCHOPH, V36, P85, DOI 10.1016/j.pnpbp.2011.10.001
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Elliot AJ, 2017, ANN BEHAV MED, V51, P240, DOI 10.1007/s12160-016-9847-z
   Finger BC, 2010, PSYCHOPHARMACOLOGY, V210, P559, DOI 10.1007/s00213-010-1858-z
   First MB, Structured clinical interview for DSM-IV Axis I disorders- Patient edition
   FitzGerald L., 2014, PSYCHOLOGY, V05, P1055, DOI [10.4236/psych.2014.59118, DOI 10.4236/PSYCH.2014.59118]
   Friedman JM, 2019, NAT METAB, V1, P754, DOI 10.1038/s42255-019-0095-y
   Graham EK, 2018, SAGE OPEN MED, V6, DOI 10.1177/2050312118774990
   Guo M, 2017, MOL PSYCHIATR, V22, P1056, DOI 10.1038/mp.2016.225
   Gustavsson JP, 2000, ACTA PSYCHIAT SCAND, V102, P217, DOI 10.1034/j.1600-0447.2000.102003217.x
   Hagger-Johnson G, 2012, PSYCHOSOM MED, V74, P596, DOI 10.1097/PSY.0b013e31825c85ca
   Hancox RJ, 2011, DIABETOL METAB SYNDR, V3, DOI 10.1186/1758-5996-3-23
   Kaptoge S, 2014, EUR HEART J, V35, P578, DOI 10.1093/eurheartj/eht367
   Kishida K, 2014, BEST PRACT RES CL EN, V28, P119, DOI 10.1016/j.beem.2013.08.006
   Lahey BB, 2009, AM PSYCHOL, V64, P241, DOI 10.1037/a0015309
   Larsen MA, 2018, NUTR METAB CARDIOVAS, V28, P1114, DOI 10.1016/j.numecd.2018.06.020
   Libby P, 2002, CIRCULATION, V105, P1135, DOI 10.1161/hc0902.104353
   Liu J, 2011, MOL PSYCHIATR, V16, P1024, DOI 10.1038/mp.2011.36
   Liu J, 2016, INT J NEUROPSYCHOPH, V19, DOI 10.1093/ijnp/pyv115
   Liu J, 2010, PSYCHOPHARMACOLOGY, V207, P535, DOI 10.1007/s00213-009-1684-3
   Lucas RE., 2020, PERSONALITY TRAITS
   Luchetti M, 2014, PSYCHONEUROENDOCRINO, V50, P181, DOI 10.1016/j.psyneuen.2014.08.014
   Margetic S, 2002, INT J OBESITY, V26, P1407, DOI 10.1038/sj.ijo.0802142
   Martin SS, 2008, J AM COLL CARDIOL, V52, P1201, DOI 10.1016/j.jacc.2008.05.060
   Michopoulos V, 2017, NEUROPSYCHOPHARMACOL, V42, P254, DOI 10.1038/npp.2016.146
   Milaneschi Y, 2017, BIOL PSYCHIAT, V81, P807, DOI 10.1016/j.biopsych.2015.10.023
   Millar K, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0058256
   Mommersteeg PMC, 2012, J PSYCHOSOM RES, V73, P326, DOI 10.1016/j.jpsychores.2012.08.019
   Mottus R, 2013, PSYCHOSOM MED, V75, P11, DOI 10.1097/PSY.0b013e31827576cc
   Mutambudzi M, 2019, OCCUP MED-OXFORD, V69, P617, DOI 10.1093/occmed/kqz169
   Mwendwa DT, 2013, BRAIN BEHAV IMMUN, V28, P72, DOI 10.1016/j.bbi.2012.10.019
   Narita K, 2008, PSYCHONEUROENDOCRINO, V33, P305, DOI 10.1016/j.psyneuen.2007.11.013
   Narita M, 2020, PSYCHOSOM MED, V82, P74, DOI 10.1097/PSY.0000000000000757
   Naudé PJW, 2018, WORLD J BIOL PSYCHIA, V19, P461, DOI 10.1080/15622975.2018.1433325
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Penninx BWJH, 2017, NEUROSCI BIOBEHAV R, V74, P277, DOI 10.1016/j.neubiorev.2016.07.003
   Ramirez A, 2009, PSYCHIAT SERV, V60, P1649, DOI 10.1176/ps.2009.60.12.1649
   Rosenthal R., 1994, The Handbook of Research Synthesis, V621, P231
   Sararoudi Reza Bagherian, 2014, Adv Biomed Res, V3, P210, DOI 10.4103/2277-9175.143254
   Schmidt FM, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00609
   Sheehan DV, 1998, J CLIN PSYCHIAT, V59, P22, DOI 10.4088/JCP.09m05305whi
   Shipley BA, 2007, PSYCHOSOM MED, V69, P923, DOI 10.1097/PSY.0b013e31815abf83
   Singh-Manoux A, 2017, CAN MED ASSOC J, V189, pE384, DOI 10.1503/cmaj.160313
   Srikanthan K, 2016, INT J MED SCI, V13, P25, DOI 10.7150/ijms.13800
   Sun FJ, 2019, MOL PSYCHIATR, V24, P126, DOI 10.1038/s41380-018-0102-9
   Sutin AR, 2010, PSYCHOL MED, V40, P1485, DOI 10.1017/S0033291709992029
   Sutin AR, 2019, J HEALTH PSYCHOL, V24, P495, DOI 10.1177/1359105316677294
   Sutin AR, 2013, PSYCHOSOM MED, V75, P505, DOI 10.1097/PSY.0b013e3182919ff4
   Syk M, 2019, PSYCHIAT RES, V272, P1, DOI 10.1016/j.psychres.2018.11.075
   Turiano NA, 2013, BRAIN BEHAV IMMUN, V28, P83, DOI 10.1016/j.bbi.2012.10.020
   Tyree SM, 2016, PHARMACOL BIOCHEM BE, V148, P15, DOI 10.1016/j.pbb.2016.05.005
   Wagner EYN, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00819
   Wang W, 2015, CNS NEUROSCI THER, V21, P425, DOI 10.1111/cns.12375
NR 74
TC 11
Z9 12
U1 0
U2 7
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAY 7
PY 2021
VL 11
IS 1
AR 9690
DI 10.1038/s41598-021-89251-y
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA SK8JJ
UT WOS:000656462600001
PM 33963214
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Warreman, EB
   Nooteboom, LA
   Leenen, PJM
   Geurts, HM
   Terry, MB
   Bos, JHJ
   Hak, E
   Hoek, HW
   van Rossum, EFC
   Vermeiren, RRJM
   Ester, WA
AF Warreman, E. B.
   Nooteboom, L. A.
   Leenen, P. J. M.
   Geurts, H. M.
   Terry, M. B.
   Bos, J. H. J.
   Hak, E.
   Hoek, H. W.
   van Rossum, E. F. C.
   Vermeiren, R. R. J. M.
   Ester, W. A.
TI Metabolic syndrome in adults with autistic traits: associated
   psychological, behavioral, and biological factors in females and males -
   a PharmLines initiative
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE autism; autistic traits; cardiovascular risk; metabolic syndrome; adults
ID MYOCARDIAL-INFARCTION; SPECTRUM QUOTIENT; DATABASE IADB.NL;
   RISK-FACTORS; 52 COUNTRIES; HEALTH; STRESS; ADOLESCENTS; COMORBIDITY;
   INTERHEART
AB Background : While cardiovascular diseases is highly prevalent and an important cause of mortality in autistic adults, knowledge on their increased cardiovascular risk is limited. Hence, this study aimed to investigate psychological, behavioral, and physical factors associated with metabolic syndrome (MetS) in adults with autistic traits.Methods : In total, 17,705 adults from the Lifelines Cohort were included and categorized using Autism Spectrum Quotient-10 sum-scores. The quartiles with highest (HQ-traits-group females: n = 2,635; males: n = 1803) and lowest levels of autistic traits (LQ-traits-group, n = idem) were analyzed. Using multivariable logistic regression, the associations between MetS and (self-reported and interviewed) psychological, behavioral, and physically measured factors in these stratified groups were investigated.Results : Among females, MetS was more common in the HQ-traits-group than in the LQ-traits-group (10.0% versus 7.5%, p < 0.01), while this was not the case among males (HQ-traits-group 13.8% versus LQ-traits-group 13.1%, p = 0.52). In both the female and male HQ-traits-group, the presence of MetS was associated with poorer self-reported health, less daily physical activity, and altered leukocyte counts.Conclusion These findings underline the relevance of adequate cardiovascular prevention in adults with higher levels of autistic traits. Future research could gain more insight into the relationship between cardiovascular risk and autistic traits in females, and into tailored cardiovascular prevention.
C1 [Warreman, E. B.; Nooteboom, L. A.; Vermeiren, R. R. J. M.; Ester, W. A.] Leiden Univ, Med Ctr, LUMC Curium, Dept Child & Adolescent Psychiat, Oegstgeest, Netherlands.
   [Leenen, P. J. M.] Univ Med Ctr Rotterdam, Dept Immunol, Erasmus MC, Rotterdam, Netherlands.
   [Geurts, H. M.] Univ Amsterdam, Dutch Autism & ADHD Res Ctr, Dept Psychol, Amsterdam, Netherlands.
   [Geurts, H. M.] Dr Leo Kannerhuis Youz Parnassia Grp, Amsterdam, Netherlands.
   [Terry, M. B.; Hoek, H. W.] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA.
   [Bos, J. H. J.; Hak, E.] Univ Groningen, Groningen Res Inst Pharm Pharmacotherapy Epidemiol, Groningen, Netherlands.
   [Hoek, H. W.] Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands.
   [Hoek, H. W.; Vermeiren, R. R. J. M.; Ester, W. A.] Parnassia Grp, The Hague, Netherlands.
   [van Rossum, E. F. C.] Univ Med Ctr Rotterdam, Dept Internal Med, Div Endocrinol, Erasmus MC, Rotterdam, Netherlands.
   [van Rossum, E. F. C.] Univ Med Ctr Rotterdam, Obes Ctr CGG, Erasmus MC, Rotterdam, Netherlands.
   [Ester, W. A.] Parnassia Grp, Sarr Autism Rotterdam Youz, Rotterdam, Netherlands.
C3 Leiden University; Leiden University Medical Center (LUMC); Leiden
   University - Excl LUMC; Erasmus University Rotterdam; Erasmus MC;
   University of Amsterdam; Columbia University; University of Groningen;
   University of Groningen; Parnassia Psychiatric Institute; Erasmus
   University Rotterdam; Erasmus MC; Erasmus University Rotterdam; Erasmus
   MC; Parnassia Psychiatric Institute
RP Warreman, EB (corresponding author), Leiden Univ, Med Ctr, LUMC Curium, Dept Child & Adolescent Psychiat, Oegstgeest, Netherlands.
EM E.B.Warreman@lumc.nl
RI Leenen, Pieter/I-5839-2013; Mohamadi, Efat/ABD-8458-2020; Ester,
   Wietske/JZE-1102-2024; van Rossum, Elisabeth/AAP-9388-2020
OI Vermeiren, Robert/0000-0002-8673-2207; van Rossum,
   Elisabeth/0000-0003-0120-4913
FU Ministry of Health10.13039/501100004726
FX We wish to acknowledge the services of the Lifelines Cohort Study, all
   study participants, the contributing research centres delivering data to
   Lifelines, and the participating IADB.nl pharmacies for providing their
   data for research. We also thank the members of Dutch 'Academic
   Workplace for Autism' for contributing to this study by sharing useful
   insights regarding the importance of selected study outcomes for the
   autistic population.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Allison C, 2012, J AM ACAD CHILD PSY, V51, P202, DOI 10.1016/j.jaac.2011.11.003
   Amos GA, 2019, J AUTISM DEV DISORD, V49, P98, DOI 10.1007/s10803-018-3695-6
   Ashwood KL, 2016, PSYCHOL MED, V46, P2595, DOI 10.1017/S0033291716001082
   Babio N, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0058354
   Broadbent J, 2013, Autism Res Treat, V2013, P984205, DOI 10.1155/2013/984205
   Cole SW, 2008, BRAIN BEHAV IMMUN, V22, P1049, DOI 10.1016/j.bbi.2008.02.006
   Croen LA, 2015, AUTISM, V19, P814, DOI 10.1177/1362361315577517
   Del Giudice M, 2018, BRAIN BEHAV IMMUN, V70, P61, DOI 10.1016/j.bbi.2018.02.013
   Denollet J, 2009, J CLIN EPIDEMIOL, V62, P452, DOI 10.1016/j.jclinepi.2008.08.006
   Dhabhar FS, 2012, PSYCHONEUROENDOCRINO, V37, P1345, DOI 10.1016/j.psyneuen.2012.05.008
   Dhanasekara CS, 2023, JAMA PEDIATR, V177, P248, DOI 10.1001/jamapediatrics.2022.5629
   Dijkstra-de Neijs L, 2020, CURR EPIDEMIOL REP, V7, P139, DOI 10.1007/s40471-020-00237-2
   Dominguez-Andres J, 2019, J LEUKOCYTE BIOL, V105, P329, DOI 10.1002/JLB.MR0318-104R
   Fortuna RJ, 2016, J GEN INTERN MED, V31, P77, DOI 10.1007/s11606-015-3509-x
   Hand BN, 2020, AUTISM, V24, P755, DOI 10.1177/1362361319890793
   Harshfield EL, 2020, JAMA-J AM MED ASSOC, V324, P2396, DOI 10.1001/jama.2020.23068
   Hillier A, 2020, PERCEPT MOTOR SKILL, V127, P874, DOI 10.1177/0031512520927560
   Hirvikoski T, 2016, BRIT J PSYCHIAT, V208, P232, DOI 10.1192/bjp.bp.114.160192
   Hwang YI, 2019, AUTISM RES, V12, P806, DOI 10.1002/aur.2086
   Lai MC, 2015, LANCET PSYCHIAT, V2, P1013, DOI 10.1016/S2215-0366(15)00277-1
   Lundin A, 2019, J AUTISM DEV DISORD, V49, P773, DOI 10.1007/s10803-018-3749-9
   McCoy SM, 2016, J AUTISM DEV DISORD, V46, P2317, DOI 10.1007/s10803-016-2762-0
   Moseley RL, 2021, HEALTH PSYCHOL, V40, P556, DOI 10.1037/hea0001108
   Rausch C, 2022, J AM MED DIR ASSOC, V23, P54, DOI 10.1016/j.jamda.2021.02.030
   Rosengren A, 2004, LANCET, V364, P953, DOI 10.1016/S0140-6736(04)17019-0
   Schendel DE, 2016, JAMA PEDIATR, V170, P243, DOI 10.1001/jamapediatrics.2015.3935
   Scholtens S, 2015, INT J EPIDEMIOL, V44, P1172, DOI 10.1093/ije/dyu229
   Sediq R, 2018, CLIN EPIDEMIOL, V10, P981, DOI 10.2147/CLEP.S163037
   Shavelle RM, 2001, J AUTISM DEV DISORD, V31, P569, DOI 10.1023/A:1013247011483
   Sheehan DV, 1998, J CLIN PSYCHIAT, V59, P22, DOI 10.4088/JCP.09m05305whi
   Sizoo BB, 2015, AUTISM, V19, P842, DOI 10.1177/1362361315589869
   Visser ST, 2013, EXPERT REV PHARM OUT, V13, P285, DOI [10.1586/erp.13.20, 10.1586/ERP.13.20]
   Vohra R, 2017, AUTISM, V21, P995, DOI 10.1177/1362361316665222
   Warreman EB, 2023, AUTISM, V27, P2173, DOI 10.1177/13623613231155324
   Warrier V, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-17794-1
   Weir E, 2021, LANCET PSYCHIAT, V8, P673, DOI 10.1016/S2215-0366(21)00160-7
   Weir E, 2021, AUTISM, V25, P681, DOI 10.1177/1362361320953652
   Wouters HJCM, 2021, HEMASPHERE, V5, DOI 10.1097/HS9.0000000000000503
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
NR 40
TC 0
Z9 0
U1 1
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD DEC 18
PY 2023
VL 14
AR 1303840
DI 10.3389/fpsyt.2023.1303840
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DT0U4
UT WOS:001134214800001
PM 38193131
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yang, ZY
   Fang, WH
   Kao, CC
   Chen, WL
AF Yang, Zhe-Yu
   Fang, Wen-Hui
   Kao, Chia-Chun
   Chen, Wei-Liang
TI Examining the association between serum IgG of oral bacteria and
   metabolic syndrome
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE periodontitis; periodontal bacteria; metabolic syndrome;
   EPI-epidemiology; multivariate analysis
ID NECROSIS-FACTOR-ALPHA; PERIODONTAL BACTERIA; OXIDATIVE STRESS; SYSTEMIC
   INFLAMMATION; CYTOKINE PRODUCTION; INSULIN-RESISTANCE; ANTIBODIES;
   DISEASE; MARKERS; INFECTIONS
AB AimThis investigation explored the relationship between oral bacteria and metabolic syndrome (METS). Materials and MethodsThere were 4,882 subjects enrolled in this cross-sectional study from the NHANES III database. The severity of periodontitis was classified into mild, moderate and severe. We measured oral bacterial antibodies. We examined the relationship between serum immunoglobulin G (IgG) antibodies of oral bacteria and METS via performing multivariate regression analysis. Mediation analysis of oral bacteria on the correlation between periodontitis and METS was also executed. ResultsAfter adjusting for covariates, the serum IgG antibodies of P. nigrescens, E. corrodens, and E. nodatum were associated with the presence of METS (p = 0.006, p = 0.014 and p = 0.018, respectively). Furthermore, serum IgG antibodies of P. intermedia, T. forsythia and V. parvula were positively associated with the presence of METS (p = 0.001, p = 0.011, and p = 0.002, respectively) and >= 4 features of METS (p = 0.019, p = 0.025, and p = 0.02, respectively). P. intermedia IgG mediated 11.2% of the relationship between periodontitis and METS. ConclusionSerological markers of oral pathogens were correlated with the presence and the number of METS features after multivariable adjustment. Oral bacteria acted as a mediator of the correlation between periodontitis and METS. Our study provided a biologically plausible explanation for the association between periodontitis and METS, which provides a comprehensive evaluation of periodontitis.
C1 [Yang, Zhe-Yu; Fang, Wen-Hui; Chen, Wei-Liang] Triserv Gen Hosp, Sch Med, Dept Family & Community Med, Div Family Med, Taipei, Taiwan.
   [Yang, Zhe-Yu; Fang, Wen-Hui; Chen, Wei-Liang] Natl Def Med Ctr, Sch Med, Taipei, Taiwan.
   [Fang, Wen-Hui; Chen, Wei-Liang] Triserv Gen Hosp Taipei, Dept Family & Community Med, Div Geriatr Med, Taipei, Taiwan.
   [Kao, Chia-Chun] Taipei Vet Gen Hosp, Dept Med Educ, Taipei, Taiwan.
   [Chen, Wei-Liang] Natl Def Med Ctr, Dept Biochem, Taipei, Taiwan.
C3 Tri-Service General Hospital; National Defense Medical Center; Taipei
   Veterans General Hospital; National Defense Medical Center
RP Chen, WL (corresponding author), Triserv Gen Hosp, Sch Med, Dept Family & Community Med, Div Family Med, Taipei, Taiwan.; Chen, WL (corresponding author), Natl Def Med Ctr, Sch Med, Taipei, Taiwan.; Chen, WL (corresponding author), Triserv Gen Hosp Taipei, Dept Family & Community Med, Div Geriatr Med, Taipei, Taiwan.; Chen, WL (corresponding author), Natl Def Med Ctr, Dept Biochem, Taipei, Taiwan.
EM weiliang0508@gmail.com
CR Bodet C, 2010, MOL ORAL MICROBIOL, V25, P102, DOI 10.1111/j.2041-1014.2010.00566.x
   Bovolini A, 2021, INT J SPORTS MED, V42, P199, DOI 10.1055/a-1263-0898
   Bretz WA, 2005, J AM GERIATR SOC, V53, P1532, DOI 10.1111/j.1532-5415.2005.53468.x
   Bullon P, 2009, J DENT RES, V88, P503, DOI 10.1177/0022034509337479
   Cekici A, 2014, PERIODONTOL 2000, V64, P57, DOI 10.1111/prd.12002
   D'Aiuto F, 2010, J DENT RES, V89, P1241, DOI 10.1177/0022034510375830
   de Avila ED, 2014, J INVESTIG CLIN DENT, V5, P91, DOI 10.1111/jicd.12087
   Demmer RT, 2012, DIABETES CARE, V35, P2235, DOI 10.2337/dc12-0072
   Desvarieux M, 2010, J HYPERTENS, V28, P1413, DOI 10.1097/HJH.0b013e328338cd36
   Dye BA, 2009, J PERIODONTOL, V80, P634, DOI 10.1902/jop.2009.080474
   Ebersole JL, 2008, J PERIODONTOL, V79, P637, DOI 10.1902/jop.2008.070455 
   Eke PI, 2012, J PERIODONTOL, V83, P1449, DOI 10.1902/jop.2012.110664
   Furman D, 2019, NAT MED, V25, P1822, DOI 10.1038/s41591-019-0675-0
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Harvey John D, 2017, Dent Clin North Am, V61, P253, DOI 10.1016/j.cden.2016.11.005
   Hayes AF, 2017, BEHAV RES THER, V98, P39, DOI 10.1016/j.brat.2016.11.001
   Hussain M, 2015, FRONT IMMUNOL, V6, DOI 10.3389/fimmu.2015.00045
   Iwasaki M, 2016, GERODONTOLOGY, V33, P193, DOI 10.1111/ger.12135
   Jaramillo A, 2013, COLOMB MEDICA, V44, P80
   Jepsen S, 2020, PERIODONTOL 2000, V83, P125, DOI 10.1111/prd.12326
   Kim SJ, 2007, FEMS IMMUNOL MED MIC, V51, P407, DOI 10.1111/j.1574-695X.2007.00318.x
   Kinane DF, 2017, NAT REV DIS PRIMERS, V3, DOI 10.1038/nrdp.2017.38
   Koh KK, 2005, J AM COLL CARDIOL, V46, P1978, DOI 10.1016/j.jacc.2005.06.082
   Liccardo D, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20061414
   MacKinnon DP, 2007, ANNU REV PSYCHOL, V58, P593, DOI 10.1146/annurev.psych.58.110405.085542
   Matera G, 2009, CLIN VACCINE IMMUNOL, V16, P1804, DOI 10.1128/CVI.00310-09
   Maury E, 2010, MOL CELL ENDOCRINOL, V314, P1, DOI 10.1016/j.mce.2009.07.031
   Merchant AT, 2014, J DENT RES, V93, P752, DOI 10.1177/0022034514538451
   Mohammadi M, 2017, REP BIOCHEM MOL BIOL, V6, P74
   Monteiro R, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/289645
   Aguilera EM, 2021, J INTERN MED, V289, P532, DOI 10.1111/joim.13180
   Aguilera EM, 2020, CARDIOVASC RES, V116, P28, DOI 10.1093/cvr/cvz201
   Nibali L, 2013, J CLIN ENDOCR METAB, V98, P913, DOI 10.1210/jc.2012-3552
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Oppermann Rui Vicente, 2012, Braz. oral res., V26, P39
   Papapanou PN, 2001, J CLIN PERIODONTOL, V28, P103, DOI 10.1034/j.1600-051x.2001.280116.x
   Picchi A, 2006, CIRC RES, V99, P69, DOI 10.1161/01.RES.0000229685.37402.80
   Plomgaard P, 2005, DIABETES, V54, P2939, DOI 10.2337/diabetes.54.10.2939
   Polak D, 2018, J CLIN PERIODONTOL, V45, P150, DOI 10.1111/jcpe.12803
   Pussinen PJ, 2004, STROKE, V35, P2020, DOI 10.1161/01.STR.0000136148.29490.fe
   Pussinen PJ, 2003, ARTERIOSCL THROM VAS, V23, P1250, DOI 10.1161/01.ATV.0000072969.71452.87
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Slocum C, 2016, J INTERN MED, V280, P114, DOI 10.1111/joim.12476
   Socransky SS, 2002, PERIODONTOL 2000, V28, P12, DOI 10.1034/j.1600-0757.2002.280102.x
   Sun Y, 2010, J PERIODONTOL, V81, P1488, DOI 10.1902/jop.2010.100004
   Tamaki N, 2014, ORAL DIS, V20, pe49, DOI 10.1111/odi.12127
   Torrungruang K, 2018, J CLIN PERIODONTOL, V45, P548, DOI 10.1111/jcpe.12884
   VanderWeele TJ, 2010, AM J EPIDEMIOL, V172, P1339, DOI 10.1093/aje/kwq332
   Zardawi F, 2021, FRONT CARDIOVASC MED, V7, DOI 10.3389/fcvm.2020.625579
NR 50
TC 0
Z9 0
U1 0
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD JUL 22
PY 2022
VL 9
AR 899063
DI 10.3389/fmed.2022.899063
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 3P0DG
UT WOS:000837205400001
PM 35935796
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Litterio, MC
   Prieto, MAV
   Adamo, AM
   Elesgaray, R
   Oteiza, PI
   Galleano, M
   Fraga, CG
AF Litterio, Maria C.
   Vazquez Prieto, Marcela A.
   Adamo, Ana M.
   Elesgaray, Rosana
   Oteiza, Patricia I.
   Galleano, Monica
   Fraga, Cesar G.
TI (-)-Epicatechin reduces blood pressure increase in high-fructose-fed
   rats: effects on the determinants of nitric oxide bioavailability
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Flavonoids; Fructose; Hypertension; Metabolic syndrome; Oxidants;
   Superoxide anion
ID NADPH OXIDASE; OXIDATIVE STRESS; ANGIOTENSIN-II; INSULIN-RESISTANCE;
   ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; VASCULAR-DISEASE;
   PROTEIN-KINASES; ACTIVATION; SYNTHASE
AB This work investigated the blood pressure (BP)-lowering effect of the flavanol (-)-epicatechin in a model of metabolic syndrome. Rats were fed a regular chow diet without (Control) or with 10% (w/v) fructose in the drinking water (high fructose, HF) for 8 weeks. A subgroup of the HF-fed rats was supplemented with (-)-epicatechin 20 mg/kg body weight (HF-EC). Dietary (-)-epicatechin reverted the increase in BP caused by the fructose treatment. In aorta, superoxide anion production and the expression of the NADPH oxidase (NOX) subunits p47(Phox) and p22(Phox) were enhanced in the HF-fed rats. The increase was prevented by (-)-epicatechin. Similar profile was observed for NOX4 expression. The activity of aorta nitric oxide synthase (NOS) was increased in the HF group and was even higher in the HF-EC rats. These effects were paralleled by increased endothelial NOS phosphorylation at the activation site Ser1177. Among the more relevant mitogen-activated protein kinase pathways in vascular tissue, c-Jun-N-terminal kinase was shown to be activated in the aorta of the HF-fed rats, and (-)-epicatechin supplementation mitigated this activation.
   Thus, the results suggest that dietary (-)-epicatechin supplementation prevented hypertension in HF-fed rats, decreasing superoxide anion production and elevating NOS activity, favoring an increase in NO bioavailability. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Litterio, Maria C.; Galleano, Monica; Fraga, Cesar G.] Univ Buenos Aires, CONICET, Sch Pharm & Biochem, Phys Chem,Inst Mol Biochem & Mol Med IBIMOL, RA-1053 Buenos Aires, DF, Argentina.
   [Vazquez Prieto, Marcela A.] Natl Univ Cuyo, Sch Med, Dept Pathol, Mendoza, Argentina.
   [Vazquez Prieto, Marcela A.] Consejo Nacl Invest Cient & Tecn, Inst Med & Expt Biol, Mendoza, Argentina.
   [Adamo, Ana M.] Univ Buenos Aires, CONICET, Sch Pharm & Biochem, Dept Biol Chem IQUIFIB, RA-1053 Buenos Aires, DF, Argentina.
   [Elesgaray, Rosana] Univ Buenos Aires, CONICET, Sch Pharm & Biochem, Physiol Inst Drug Chem & Metab IQUIMEFA, RA-1053 Buenos Aires, DF, Argentina.
   [Oteiza, Patricia I.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Oteiza, Patricia I.] Univ Calif Davis, Dept Environm Toxicol, Davis, CA 95616 USA.
C3 University of Buenos Aires; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); University Nacional Cuyo Mendoza;
   Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   University of Buenos Aires; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); University of Buenos Aires; Consejo
   Nacional de Investigaciones Cientificas y Tecnicas (CONICET); University
   of California System; University of California Davis; University of
   California System; University of California Davis
RP Galleano, M (corresponding author), Univ Buenos Aires, CONICET, Sch Pharm & Biochem, Phys Chem,Inst Mol Biochem & Mol Med IBIMOL, RA-1053 Buenos Aires, DF, Argentina.
EM mgallean@ffyb.uba.ar
RI Prieto, Marcela/W-4291-2019; Fraga, Cesar/Q-8161-2019; Adamo,
   Ana/U-7961-2019
OI Fraga, Cesar G./0000-0003-4168-9927
FU Universidad de Buenos Aires (UBACyT) [20020130100760BA, 20020120100177,
   20020120100132]; Consejo Nacional de Investigaciones Cientificas y
   Tecnologicas (CONICET) [PIP-0612]; Agencia Nacional de Promocion
   Cientifica y Tecnologica [ANPCyT BID PICT 2012-0765, 2011-1957]
FX This study was supported by grants from the Universidad de Buenos Aires
   (UBACyT 20020130100760BA, 20020120100177, 20020120100132), Consejo
   Nacional de Investigaciones Cientificas y Tecnologicas (CONICET)
   (PIP-0612) and Agencia Nacional de Promocion Cientifica y Tecnologica
   (ANPCyT BID PICT 2012-0765, 2011-1957).
CR Actis-Goretta L, 2012, FREE RADICAL BIO MED, V53, P787, DOI 10.1016/j.freeradbiomed.2012.05.023
   Alam MA, 2014, ADV NUTR, V5, P404, DOI 10.3945/an.113.005603
   Almoosawi S, 2010, BRIT J NUTR, V103, P842, DOI 10.1017/S0007114509992431
   Bedard K, 2007, PHYSIOL REV, V87, P245, DOI 10.1152/physrev.00044.2005
   Bettaieb A, 2014, FREE RADICAL BIO MED, V72, P247, DOI 10.1016/j.freeradbiomed.2014.04.011
   Cai H, 2000, CIRC RES, V87, P840, DOI 10.1161/01.RES.87.10.840
   Chen CA, 2008, J BIOL CHEM, V283, P27038, DOI 10.1074/jbc.M802269200
   Costa MA, 2004, J HYPERTENS, V22, P1561, DOI 10.1097/01.hjh.0000125445.28861.8a
   Costa MA, 2010, AM J PHYSIOL-HEART C, V298, pH778, DOI 10.1152/ajpheart.00488.2009
   Crozier A, 2009, NAT PROD REP, V26, P1001, DOI 10.1039/b802662a
   Csányi G, 2009, FREE RADICAL BIO MED, V47, P1254, DOI 10.1016/j.freeradbiomed.2009.07.022
   Davison K, 2008, INT J OBESITY, V32, P1289, DOI 10.1038/ijo.2008.66
   Ding H, 2007, EUR J PHARMACOL, V561, P121, DOI 10.1016/j.ejphar.2006.12.034
   Drummond GR, 2011, NAT REV DRUG DISCOV, V10, P453, DOI 10.1038/nrd3403
   Ervin R Bethene, 2009, Natl Health Stat Report, P1
   Förstermann U, 2006, CIRCULATION, V113, P1708, DOI 10.1161/CIRCULATIONAHA.105.602532
   FORSTERMANN U, 1994, HYPERTENSION, V23, P1121, DOI 10.1161/01.HYP.23.6.1121
   Fraga CG, 2007, IUBMB LIFE, V59, P308, DOI 10.1080/15216540701230529
   Fraga CG, 2011, FREE RADICAL BIO MED, V51, P813, DOI 10.1016/j.freeradbiomed.2011.06.002
   Fraga CG, 2011, J CLIN BIOCHEM NUTR, V48, P63, DOI 10.3164/jcbn.11-010FR
   Fraga CG, 2010, MOL ASPECTS MED, V31, P435, DOI 10.1016/j.mam.2010.09.006
   Galleano M, 2013, IUBMB LIFE, V65, P710, DOI 10.1002/iub.1185
   Galleano M, 2012, ANN NY ACAD SCI, V1259, P87, DOI 10.1111/j.1749-6632.2012.06511.x
   Galleano M, 2010, ARCH BIOCHEM BIOPHYS, V501, P23, DOI 10.1016/j.abb.2010.04.005
   GarciaCardena G, 1997, J BIOL CHEM, V272, P25437, DOI 10.1074/jbc.272.41.25437
   Giani JF, 2009, AM J PHYSIOL-ENDOC M, V296, pE262, DOI 10.1152/ajpendo.90678.2008
   Ginnan R, 2013, FREE RADICAL BIO MED, V54, P125, DOI 10.1016/j.freeradbiomed.2012.09.026
   Go YM, 1999, AM J PHYSIOL-HEART C, V277, pH1647, DOI 10.1152/ajpheart.1999.277.4.H1647
   GOLDSTEIN S, 1995, FREE RADICAL BIO MED, V19, P505, DOI 10.1016/0891-5849(95)00034-U
   Gómez-Guzmán M, 2012, FREE RADICAL BIO MED, V52, P70, DOI 10.1016/j.freeradbiomed.2011.09.015
   Gómez-Guzmán M, 2011, BRIT J NUTR, V106, P1337, DOI 10.1017/S0007114511004314
   Govers R, 2001, AM J PHYSIOL-RENAL, V280, pF193, DOI 10.1152/ajprenal.2001.280.2.F193
   Grassi D, 2008, J NUTR, V138, P1671, DOI 10.1093/jn/138.9.1671
   Griendling KK, 2003, CIRCULATION, V108, P1912, DOI 10.1161/01.CIR.0000093660.86242.BB
   Kelley GL, 2004, ENDOCRINOLOGY, V145, P548, DOI 10.1210/en.2003-1167
   Knaze V, 2012, BRIT J NUTR, V108, P1095, DOI 10.1017/S0007114511006386
   Lassègue B, 2010, ARTERIOSCL THROM VAS, V30, P653, DOI 10.1161/ATVBAHA.108.181610
   Li JM, 2004, CIRCULATION, V109, P1307, DOI 10.1161/01.CIR.0000118463.23388.B9
   Litterio MC, 2012, FREE RADICAL BIO MED, V53, P1894, DOI 10.1016/j.freeradbiomed.2012.08.585
   Lobysheva I, 2011, ARTERIOSCL THROM VAS, V31, P2098, DOI 10.1161/ATVBAHA.111.230623
   Lteif AA, 2005, CIRCULATION, V112, P32, DOI 10.1161/CIRCULATIONAHA.104.520130
   Mackenzie GG, 2009, BIOCHEM PHARMACOL, V78, P1252, DOI 10.1016/j.bcp.2009.06.111
   Mount PF, 2006, ACTA PHYSIOL, V187, P433, DOI 10.1111/j.1748-1716.2006.01582.x
   OBERHAMMER F, 1993, J CELL SCI, V104, P317
   Ottaviani JI, 2012, FREE RADICAL BIO MED, V52, P1403, DOI 10.1016/j.freeradbiomed.2011.12.010
   Paravicini TM, 2008, DIABETES CARE, V31, pS170, DOI 10.2337/dc08-s247
   Pendyala S, 2009, ANTIOXID REDOX SIGN, V11, P841, DOI [10.1089/ars.2008.2231, 10.1089/ARS.2008.2231]
   Piotrkowski B, 2015, FOOD FUNCT, V6, P155, DOI 10.1039/c4fo00554f
   Ramirez-Sanchez I, 2011, AM J PHYSIOL-CELL PH, V300, pC880, DOI 10.1152/ajpcell.00406.2010
   Schroeter H, 2006, P NATL ACAD SCI USA, V103, P1024, DOI 10.1073/pnas.0510168103
   Touyz RM, 2004, J HYPERTENS, V22, P1141, DOI 10.1097/00004872-200406000-00015
   Vazquez-Prieto MA, 2012, ARCH BIOCHEM BIOPHYS, V527, P113, DOI 10.1016/j.abb.2012.02.019
   Verstraeten SV, 2008, FREE RADICAL RES, V42, P864, DOI 10.1080/10715760802471452
   Viedt C, 2000, ARTERIOSCL THROM VAS, V20, P940, DOI 10.1161/01.ATV.20.4.940
   Vogiatzoglou A, 2014, BRIT J NUTR, V111, P1463, DOI 10.1017/S0007114513003930
   Xiong X, 2011, EVID-BASED COMPL ALT, V2011, DOI 10.1093/ecam/neq063
   Yoshizumi M, 2000, J BIOL CHEM, V275, P11706, DOI 10.1074/jbc.275.16.11706
   Zakula Z, 2011, EUR J NUTR, V50, P543, DOI 10.1007/s00394-010-0161-4
NR 58
TC 42
Z9 45
U1 0
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD JUL
PY 2015
VL 26
IS 7
BP 745
EP 751
DI 10.1016/j.jnutbio.2015.02.004
PG 7
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA CK9LM
UT WOS:000356561600008
PM 25943039
OA Green Published
DA 2025-06-11
ER

PT J
AU Meneses, ME
   Camargo, A
   Perez-Martinez, P
   Delgado-Lista, J
   Cruz-Teno, C
   Jimenez-Gomez, Y
   Paniagua, JA
   Gutierrez-Mariscal, FM
   Tinahones, FJ
   Vidal-Puig, A
   Roche, HM
   Perez-Jimenez, F
   Malagon, MM
   Lopez-Miranda, J
AF Meneses, Maria E.
   Camargo, Antonio
   Perez-Martinez, Pablo
   Delgado-Lista, Javier
   Cruz-Teno, Cristina
   Jimenez-Gomez, Yolanda
   Paniagua, Juan A.
   Gutierrez-Mariscal, Francisco M.
   Tinahones, Francisco J.
   Vidal-Puig, Antonio
   Roche, Helen M.
   Perez-Jimenez, Francisco
   Malagon, Maria M.
   Lopez-Miranda, Jose
TI Postprandial inflammatory response in adipose tissue of patients with
   metabolic syndrome after the intake of different dietary models
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Adipose tissue; Diet; Inflammation; Metabolic syndrome; Postprandial
   state
ID ENDOPLASMIC-RETICULUM STRESS; BLOOD MONONUCLEAR-CELLS; FACTOR-KAPPA-B;
   MACROPHAGE ACCUMULATION; OLIVE OIL; ACTIVATION; ADIPONECTIN; EXPRESSION;
   LEUKOCYTES; LIPEMIA
AB Scope: Dysfunctional adipose tissue may be an important trigger of molecular inflammatory pathways that cause cardiovascular diseases. Our aim was to determine whether the specific quality and quantity of dietary fat produce differential postprandial inflammatory responses in adipose tissue from metabolic syndrome (MetS) patients.
   Methods and results: A randomized, controlled trial conducted within the LIPGENE study assigned MetS patients to 1 of 4 diets: (i) high-saturated fatty acid (HSFA), (ii) high-monounsaturated fatty acid (HMUFA), (iii) low-fat, high-complex carbohydrate diet supplemented with n-3 polyunsaturated fatty acids (PUFA) (LFHCC n-3), and (iv) low-fat, high-complex carbohydrate diet supplemented with placebo (LFHCC), for 12 wk each. A fat challenge reflecting the fatty acid composition as the original diets was conducted post-intervention. We found that p65 gene expression is induced in adipose tissue (p50.003) at the postprandial state. In addition, I kappa Ba (p<0.001), MCP-1 (p<0.001) and IL-1 beta (p<0.001) gene expression was equally induced in the postprandial state, regardless of the quality and quantity of the dietary fat. Notably, IL-6 transcripts were only detected in the postprandial state.
   Conclusions: Our results indicate that individuals with MetS typically exhibit exacerbated adipose tissue postprandial inflammatory responses, which seem to be independent of the quality and quantity of dietary fat.
C1 [Meneses, Maria E.; Camargo, Antonio; Perez-Martinez, Pablo; Delgado-Lista, Javier; Cruz-Teno, Cristina; Paniagua, Juan A.; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Univ Cordoba, Reina Sofia Univ Hosp, IMIBIC, Lipids & Atherosclerosis Unit, E-14004 Cordoba, Spain.
   [Meneses, Maria E.; Camargo, Antonio; Perez-Martinez, Pablo; Delgado-Lista, Javier; Cruz-Teno, Cristina; Paniagua, Juan A.; Gutierrez-Mariscal, Francisco M.; Tinahones, Francisco J.; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Cordoba, Spain.
   [Jimenez-Gomez, Yolanda; Malagon, Maria M.] Univ Cordoba, Dept Cell Biol Physiol & Immunol, E-14004 Cordoba, Spain.
   [Gutierrez-Mariscal, Francisco M.; Tinahones, Francisco J.] Hosp Univ Virgen de la Victoria, Malaga, Spain.
   [Vidal-Puig, Antonio] Univ Cambridge, Inst Metab Sci, Metab Res Labs, Cambridge, England.
   [Roche, Helen M.] Univ Coll Dublin, UCD Conway Inst Biomol & Biomed Res, Sch Publ Hlth, Nutrigen Res Grp, Dublin 2, Ireland.
C3 Universidad de Cordoba; Hospital Universitario Reina Sofia - Cordoba;
   Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica
   en Red; CIBEROBN; Universidad de Cordoba; Hospital Virgen de la
   Victoria; Universidad de Malaga; University of Cambridge; University
   College Dublin
RP Lopez-Miranda, J (corresponding author), Univ Cordoba, Reina Sofia Univ Hosp, IMIBIC, Lipids & Atherosclerosis Unit, Avda Menendez Pidal S-N, E-14004 Cordoba, Spain.
EM jlopezmir@uco.es
RI Jimenez, Francisco/AAJ-9559-2021; Delgado-Lista, Javier/KAM-7412-2024;
   Mariscal, Francisco/AAH-3689-2020; Lopez-Miranda, Jose/Y-8306-2019;
   Tinahones, Francisco/AAB-2882-2020; Jimenez-Gomez, Yolanda/Y-3742-2018;
   Meneses, Maria E./Q-2572-2018; Perez Martinez, Pablo/AEL-6176-2022;
   MALAGON, MARIA M/L-5386-2014; Camargo Garcia, Antonio/G-9720-2015;
   Gutierrez Mariscal, Francisco Miguel/F-9804-2016
OI Jimenez-Gomez, Yolanda/0000-0002-1607-2717; Meneses, Maria
   E./0000-0002-7689-7024; Tinahones, Francisco J/0000-0001-6871-4403;
   Vidal-Puig, Antonio/0000-0003-4220-9577; Delgado Lista, Francisco
   Javier/0000-0002-2982-2716; Perez Jimenez,
   Francisco/0000-0001-9808-1280; Perez Martinez,
   Pablo/0000-0001-7716-8117; Perez-Jimenez, Francisco/0000-0001-7499-7681;
   Roche, Helen/0000-0002-0628-3318; Lopez-Miranda,
   Jose/0000-0002-8844-0718; MALAGON, MARIA M/0000-0002-2419-2727; , Juan
   A. Paniagua/0000-0003-2892-980X; Camargo Garcia,
   Antonio/0000-0002-0415-4184; Gutierrez Mariscal, Francisco
   Miguel/0000-0003-3353-2188
FU European Union (LIPGENE) from the Ministerio de Ciencia e Innovacion
   [505944, AGL2004-07907, AGL2006-01979, AGL2009-12270]; CIBER
   Fisiopatologia de la Obesidad y Nutricion [CB06/03/0047]; Consejeria de
   Innovacion, Ciencia y Empresa, Junta de Andalucia [P06-CTS-01425,
   CTS-03039]; Consejeria de Salud, Junta de Andalucia [06/128, 07/43,
   PI-0193]; Fondo Europeo de Desarrollo Regional (FEDER); Consejo Nacional
   de Ciencia y Tecnologia, Mexico. (CONACYT)
FX This work was supported in part by research grants from the European
   Union (LIPGENE European Integrated Project-505944), from the Ministerio
   de Ciencia e Innovacion (grant numbers AGL2004-07907, AGL2006-01979,
   AGL2009-12270 (to J. L.-M.)); CIBER Fisiopatologia de la Obesidad y
   Nutricion (grant number CB06/03/0047); Consejeria de Innovacion, Ciencia
   y Empresa, Junta de Andalucia (grant number P06-CTS-01425 (to J. L.-M.)
   CTS-03039 (to MMM)); and Consejeria de Salud, Junta de Andalucia (grant
   numbers 06/128, 07/43, PI-0193 (to J. L.-M.)); Fondo Europeo de
   Desarrollo Regional (FEDER). The CIBEROBN is an initiative of the
   Instituto de Salud Carlos III, Madrid, Spain; MEM has a fellowship by
   Consejo Nacional de Ciencia y Tecnologia, Mexico. (CONACYT). We thank to
   M<SUP>a</SUP> Jose Gomez-Luna for technical support.
CR Aljada A, 2004, AM J CLIN NUTR, V79, P682
   ALLAIN CC, 1974, CLIN CHEM, V20, P470
   Bellido C, 2004, AM J CLIN NUTR, V80, P1487, DOI 10.1093/ajcn/80.6.1487
   Blackburn P, 2006, OBESITY, V14, P1747, DOI 10.1038/oby.2006.201
   Bruun JM, 2005, J CLIN ENDOCR METAB, V90, P2282, DOI 10.1210/jc.2004-1696
   BUCOLO G, 1973, CLIN CHEM, V19, P476
   Eizirik DL, 2008, ENDOCR REV, V29, P42, DOI 10.1210/er.2007-0015
   El Khoury D, 2010, ATHEROSCLEROSIS, V210, P307, DOI 10.1016/j.atherosclerosis.2009.11.017
   Gabrielsson BG, 2005, OBES RES, V13, P649, DOI 10.1038/oby.2005.72
   Gregor MF, 2007, J LIPID RES, V48, P1905, DOI 10.1194/jlr.R700007-JLR200
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Grundy SM, 2004, ARTERIOSCL THROM VAS, V24, pE13, DOI 10.1161/01.ATV.0000111245.75752.C6
   Gustafson B, 2007, ARTERIOSCL THROM VAS, V27, P2276, DOI 10.1161/ATVBAHA.107.147835
   Gutierrez-Mariscal FM, 2012, AGE, V34, P389, DOI 10.1007/s11357-011-9229-1
   Jimenez-Gomez Yolanda, 2009, Atherosclerosis, V204, pe70, DOI 10.1016/j.atherosclerosis.2008.09.011
   Kallio P, 2008, AM J CLIN NUTR, V87, P1497, DOI 10.1093/ajcn/87.5.1497
   Kennedy A, 2009, J NUTR, V139, P1, DOI 10.3945/jn.108.098269
   Lairon D, 2007, EUR J CLIN NUTR, V61, P1145, DOI 10.1038/sj.ejcn.1602749
   Lopez-Miranda J, 2007, BRIT J NUTR, V98, P458, DOI 10.1017/S000711450774268X
   Magné J, 2010, J NUTR BIOCHEM, V21, P550, DOI 10.1016/j.jnutbio.2009.03.004
   Manning PJ, 2008, OBESITY, V16, P2046, DOI 10.1038/oby.2008.334
   McGrath KCY, 2009, ARTERIOSCL THROM VAS, V29, P877, DOI 10.1161/ATVBAHA.109.184663
   Mohanty P, 2002, AM J CLIN NUTR, V75, P767, DOI 10.1093/ajcn/75.4.767
   Paniagua JA, 2007, DIABETES CARE, V30, P1717, DOI 10.2337/dc06-2220
   Perez-Martinez P, 2007, ATHEROSCLEROSIS, V194, pE141, DOI 10.1016/j.atherosclerosis.2006.11.033
   Phillips C, 2006, CURR OPIN CARDIOL, V21, P185, DOI 10.1097/01.hco.0000221579.25878.11
   Poppitt SD, 2008, NUTRITION, V24, P322, DOI 10.1016/j.nut.2007.12.012
   Ruotolo Giacomo, 2002, Curr Cardiol Rep, V4, P494, DOI 10.1007/s11886-002-0113-6
   Shaw DI, 2009, BRIT J NUTR, V101, P750, DOI 10.1017/S0007114508039962
   Shen J, 2007, J NUTR, V137, P1846, DOI 10.1093/jn/137.8.1846
   Shoelson SE, 2007, GASTROENTEROLOGY, V132, P2169, DOI 10.1053/j.gastro.2007.03.059
   Smythies LE, 2010, AM J PHYSIOL-CELL PH, V298, pC1538, DOI 10.1152/ajpcell.00467.2009
   Stow JL, 2009, IMMUNOBIOLOGY, V214, P601, DOI 10.1016/j.imbio.2008.11.005
   Subramanian S, 2009, CURR OPIN LIPIDOL, V20, P39, DOI 10.1097/MOL.0b013e32831bef8b
   van Dijk SJ, 2009, AM J CLIN NUTR, V90, P1656, DOI 10.3945/ajcn.2009.27792
   van Oostrom AJHHM, 2009, NETH J MED, V67, P13
   van Oostrom AJHHM, 2004, ATHEROSCLEROSIS, V177, P175, DOI 10.1016/j.atherosclerosis.2004.07.004
   van Oostrom AJHHM, 2007, ATHEROSCLEROSIS, V190, P167, DOI 10.1016/j.atherosclerosis.2006.01.009
   Vandesompele J, 2002, GENOME BIOL, V3, DOI 10.1186/gb-2002-3-7-research0034
   WARNICK GR, 1982, CLIN CHEM, V28, P1379
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Zhang JW, 2010, ENDOCRINE, V37, P157, DOI 10.1007/s12020-009-9283-y
   Zhang KZ, 2008, NATURE, V454, P455, DOI 10.1038/nature07203
NR 43
TC 48
Z9 50
U1 0
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD DEC
PY 2011
VL 55
IS 12
BP 1759
EP 1770
DI 10.1002/mnfr.201100200
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 855RM
UT WOS:000297581900002
PM 22144044
DA 2025-06-11
ER

PT J
AU Behl, T
   Gupta, A
   Chigurupati, S
   Singh, S
   Sehgal, A
   Badavath, VN
   Alhowail, A
   Mani, V
   Bhatia, S
   Al-Harrasi, A
   Bungau, S
AF Behl, Tapan
   Gupta, Amit
   Chigurupati, Sridevi
   Singh, Sukhbir
   Sehgal, Aayush
   Badavath, Vishnu Nayak
   Alhowail, Ahmad
   Mani, Vasudevan
   Bhatia, Saurabh
   Al-Harrasi, Ahmed
   Bungau, Simona
TI Natural and Synthetic Agents Targeting Reactive Carbonyl Species against
   Metabolic Syndrome
SO MOLECULES
LA English
DT Review
DE reactive carbonyls species; advanced glycation end products;
   sequestering agents; advanced lipo-oxidation end products; metabolism;
   metabolic syndrome
ID GLYCATION END-PRODUCTS; SALT-SENSITIVE HYPERTENSION; VITAMIN-E
   SUPPLEMENTATION; INDUCED OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE;
   L-CARNOSINE; PROTEIN CARBONYLATION; MOLECULAR-MECHANISMS;
   INSULIN-RESISTANCE; DIABETES-MELLITUS
AB Reactive carbonyl species (RCS) may originate from the oxidation of unsaturated fatty acids and sugar in conditions of pathology. They are known to have high reactivity towards DNA as well as nucleophilic sites of proteins, resulting in cellular dysfunction. It has been considered that various pathological conditions are associated with an increased level of RCS and their reaction products. Thus, regulating the levels of RCS may be associated with the mitigation of various metabolic and neurodegenerative disorders. In order to perform a comprehensive review, various literature databases, including MEDLINE, EMBASE, along with Google Scholar, were utilized to obtain relevant articles. The voluminous review concluded that various synthetic and natural agents are available or in pipeline research that hold tremendous potential to be used as a drug of choice in the therapeutic management of metabolic syndrome, including obesity, dyslipidemia, diabetes, and diabetes-associated complications of atherosclerosis, neuropathy, and nephropathy. From the available data, it may be emphasized that various synthetic agents, such as carnosine and simvastatin, and natural agents, such as polyphenols and terpenoids, can become a drug of choice in the therapeutic management for combating metabolic syndromes that involve RCS in their pathophysiology. Since the RCS are known to regulate the biological processes, future research warrants detailed investigations to decipher the precise mechanism.
C1 [Behl, Tapan; Gupta, Amit; Singh, Sukhbir; Sehgal, Aayush; Badavath, Vishnu Nayak] Chitkara Univ, Chitkara Coll Pharm, Rajpura 140401, India.
   [Chigurupati, Sridevi] Qassim Univ, Coll Pharm, Dept Med Chem & Pharmacognosy, Buraydah, Saudi Arabia.
   [Alhowail, Ahmad; Mani, Vasudevan] Qassim Univ, Coll Pharm, Dept Pharmacol & Toxicol, Buraydah 51452, Saudi Arabia.
   [Bhatia, Saurabh; Al-Harrasi, Ahmed] Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa POB 33, Birkat Al Mauz, Oman.
   [Bhatia, Saurabh] Univ Petr & Energy Studies, Sch Hlth Sci, Dehra Dun 248007, Uttarakhand, India.
   [Bungau, Simona] Univ Oradea, Fac Med & Pharm, Dept Pharm, Oradea 410073, Romania.
   [Bungau, Simona] Univ Oradea, Doctoral Sch Biomed Sci, Oradea 410087, Romania.
C3 Chitkara University, Punjab; Qassim University; Qassim University;
   University of Nizwa; University of Petroleum & Energy Studies (UPES);
   University of Oradea; University of Oradea
RP Behl, T (corresponding author), Chitkara Univ, Chitkara Coll Pharm, Rajpura 140401, India.; Bungau, S (corresponding author), Univ Oradea, Fac Med & Pharm, Dept Pharm, Oradea 410073, Romania.; Bungau, S (corresponding author), Univ Oradea, Doctoral Sch Biomed Sci, Oradea 410087, Romania.
EM tapanbehl31@gmail.com; amitgupta2508@gmail.com; s.chigurupati@qu.edu.sa;
   sukhbir.singh@chitkara.edu.in; aayushsehgal00@gmail.com;
   vishnu.badavath@chitkara.edu.in; aalhowail@qu.edu.sa; v.samy@qu.edu.sa;
   sbsaurabhbhatia@gmail.com; aharrasi@unizwa.edu.om;
   simonabungau@gmail.com
RI Singh, Dr. Sukhbir/AAZ-7468-2020; Ul-Hamid, Anwar/B-7297-2015; Bungau,
   Simona Gabriela/C-1831-2015; Mani, Vasudevan/H-6371-2013; Badavath, Dr.
   Vishnu Nayak/H-2671-2016; CHIGURUPATI, SRIDEVI/GRX-8274-2022
OI Gupta, Amit/0000-0002-5447-9980; Mani, Vasudevan/0000-0002-8440-8366;
   Badavath, Dr. Vishnu Nayak/0000-0002-6433-2691; Singh,
   Sukhbir/0000-0003-0692-7002; CHIGURUPATI, SRIDEVI/0000-0002-1081-2964
FU University of Oradea, Oradea, Romania
FX Funding for the publication of this paper is provided by the University
   of Oradea, Oradea, Romania, by an Internal project.
CR Adineh H, 2021, AQUACULT NUTR, V27, P417, DOI 10.1111/anu.13194
   Ahmad S, 2017, CURR VASC PHARMACOL, V15, P352, DOI 10.2174/1570161115666170327162639
   AL-Khateeb A.R., 2018, REGEN RES, V6, P1
   Al-Sawalha NA, 2019, LIFE SCI, V237, DOI 10.1016/j.lfs.2019.116905
   Aldini G, 2002, BIOCHEM BIOPH RES CO, V298, P699, DOI 10.1016/S0006-291X(02)02545-7
   Aldini G, 2003, J MASS SPECTROM, V38, P1160, DOI 10.1002/jms.533
   Aldini G, 2007, MED RES REV, V27, P817, DOI 10.1002/med.20073
   Aldini G, 2021, FREE RADICAL RES, V55, P321, DOI 10.1080/10715762.2020.1856830
   Aldini G, 2011, J CELL MOL MED, V15, P1339, DOI 10.1111/j.1582-4934.2010.01101.x
   Alvi SS, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/7086951
   Amunom I, 2006, ENZYMOL MOL BIOL CAR, V12, P118
   Anderson EJ, 2018, J CLIN INVEST, V128, P5280, DOI 10.1172/JCI94307
   Silveira AAA, 2018, INT IMMUNOPHARMACOL, V58, P160, DOI 10.1016/j.intimp.2018.03.025
   Babizhayev MA, 2010, AM J THER, V17, P373, DOI 10.1097/MJT.0b013e3181d6b6c3
   Baye E, 2019, AMINO ACIDS, V51, P73, DOI 10.1007/s00726-018-2623-6
   Beisswenger PJ, 1999, DIABETES, V48, P198, DOI 10.2337/diabetes.48.1.198
   Bhakkiyalakshmi E, 2015, PHARMACOL RES, V91, P104, DOI 10.1016/j.phrs.2014.10.004
   Bierhaus A, 2009, DIABETOLOGIA, V52, P2251, DOI 10.1007/s00125-009-1458-9
   Bjelakovic G, 2012, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD007176.pub2, 10.1590/1516-3180.20151332T1]
   Bladé C, 2013, MOL NUTR FOOD RES, V57, P58, DOI 10.1002/mnfr.201200454
   Boldyrev AA, 2013, PHYSIOL REV, V93, P1803, DOI 10.1152/physrev.00039.2012
   Bonomini F, 2015, AGING DIS, V6, P109, DOI 10.14336/AD.2014.0305
   Brame CJ, 1999, J BIOL CHEM, V274, P13139, DOI 10.1074/jbc.274.19.13139
   Burri BJ, 2009, INT J FOOD SCI NUTR, V60, P1, DOI 10.1080/09637480701782084
   Cahill LE, 2009, AM J CLIN NUTR, V90, P1411, DOI 10.3945/ajcn.2009.28327
   Carrier A, 2017, ANTIOXID REDOX SIGN, V26, P429, DOI 10.1089/ars.2016.6929
   Ceconi C, 2003, ARCH BIOCHEM BIOPHYS, V420, P217, DOI 10.1016/j.abb.2003.06.002
   Cederroth CR, 2009, MOL CELL ENDOCRINOL, V304, P30, DOI 10.1016/j.mce.2009.02.027
   Chen XG, 2013, HYPERTENS RES, V36, P361, DOI 10.1038/hr.2012.204
   Chen XY, 2014, J FUNCT FOODS, V8, P259, DOI 10.1016/j.jff.2014.03.025
   Chetyrkin S, 2011, BIOCHEMISTRY-US, V50, P6102, DOI 10.1021/bi200757d
   Chez MG, 2002, J CHILD NEUROL, V17, P833, DOI 10.1177/08830738020170111501
   Colzani M, 2014, J PHARMACEUT BIOMED, V91, P108, DOI 10.1016/j.jpba.2013.12.024
   Coughlan MT, 2009, J AM SOC NEPHROL, V20, P742, DOI 10.1681/ASN.2008050514
   Crawford P, 2009, J AM BOARD FAM MED, V22, P507, DOI 10.3122/jabfm.2009.05.080093
   Cuccurullo C, 2006, ARTERIOSCL THROM VAS, V26, P2716, DOI 10.1161/01.ATV.0000249630.02085.12
   Dalle-Donne I, 2006, J CELL MOL MED, V10, P389, DOI 10.1111/j.1582-4934.2006.tb00407.x
   Davidson MB, 1997, AM J MED, V102, P99, DOI 10.1016/S0002-9343(96)00353-1
   de Courten B, 2016, OBESITY, V24, P1027, DOI 10.1002/oby.21434
   de Paula FJA, 2010, ARQ BRAS ENDOCRINOL, V54, P150, DOI 10.1590/S0004-27302010000200010
   Depypere HT, 2014, MATURITAS, V77, P191, DOI 10.1016/j.maturitas.2013.11.001
   DO JEONG-RYONG, 2005, [Korean Journal of Food Science and Technology, 한국식품과학회지], V37, P206
   Dobrian AD, 2001, HYPERTENSION, V37, P554, DOI 10.1161/01.HYP.37.2.554
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Estey T, 2007, EXP EYE RES, V84, P3, DOI 10.1016/j.exer.2006.04.010
   Fahim VF, 2019, BRAIN RES BULL, V144, P21, DOI 10.1016/j.brainresbull.2018.10.012
   Figarola JL, 2014, APOPTOSIS, V19, P776, DOI 10.1007/s10495-014-0974-3
   Freedman BI, 2007, NEPHROL DIAL TRANSPL, V22, P1131, DOI 10.1093/ndt/gfl717
   Fujita T, 2007, NEPHROL DIAL TRANSPL, V22, P3102, DOI 10.1093/ndt/gfm409
   Fujita T, 2010, HYPERTENSION, V55, P813, DOI 10.1161/HYPERTENSIONAHA.109.149062
   Fuloria S, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9111075
   Gallant S, 2000, BIOCHEMISTRY-MOSCOW+, V65, P866
   Gasparotto J, 2014, J NUTR BIOCHEM, V25, P1282, DOI 10.1016/j.jnutbio.2014.07.004
   González-Castejón M, 2011, PHARMACOL RES, V64, P438, DOI 10.1016/j.phrs.2011.07.004
   Goo AKY, 1996, J FAM PRACTICE, V42, P612
   Graf BL, 2010, CURR OPIN INVEST DR, V11, P1107
   Grundy Scott M, 2005, Clin Cornerstone, V7, P36, DOI 10.1016/S1098-3597(05)80066-3
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Gualano B, 2012, AMINO ACIDS, V43, P21, DOI 10.1007/s00726-011-1165-y
   Guo Y, 2019, EXP THER MED, V17, P2641, DOI 10.3892/etm.2019.7223
   Gupta A, 2021, MOL BIOL REP, V48, P2761, DOI 10.1007/s11033-021-06257-5
   Hasani-Ranjbar S, 2010, INT J PHARMACOL, V6, P315, DOI 10.3923/ijp.2010.315.325
   Hasani-Ranjbar S, 2010, CURR PHARM DESIGN, V16, P2935, DOI 10.2174/138161210793176464
   Hensley K, 2002, ARCH BIOCHEM BIOPHYS, V397, P377, DOI 10.1006/abbi.2001.2630
   Hill AM, 2007, AM J CLIN NUTR, V85, P1267, DOI 10.1093/ajcn/85.5.1267
   Hipkiss AR, 2005, MECH AGEING DEV, V126, P1034, DOI 10.1016/j.mad.2005.05.002
   Holmes SB, 2001, BRIT J ORAL MAX SURG, V39, P286, DOI 10.1054/bjom.2000.0566
   Holvoet P, 2008, Verh K Acad Geneeskd Belg, V70, P193
   Hwang SW, 2016, MOLECULES, V21, DOI 10.3390/molecules21030280
   Ikeda M, 2017, APPL ENVIRON MICROB, V83, DOI 10.1128/AEM.01322-17
   Ishibashi Y, 2011, METABOLISM, V60, P1271, DOI 10.1016/j.metabol.2011.01.010
   Isomaa B, 2001, DIABETOLOGIA, V44, P1148, DOI 10.1007/s001250100615
   Janssen B, 2005, DIABETES, V54, P2320, DOI 10.2337/diabetes.54.8.2320
   Kurata H, 2006, J PHARMACOL EXP THER, V319, P640, DOI 10.1124/jpet.106.110122
   Lapolla A, 2005, CLIN BIOCHEM, V38, P103, DOI 10.1016/j.clinbiochem.2004.09.007
   Lawson KA, 2007, J NATL CANCER I, V99, P754, DOI 10.1093/jnci/djk177
   Lee YM, 2016, J AGR FOOD CHEM, V64, P2492, DOI 10.1021/acs.jafc.5b05361
   Lee YT, 2005, EUR J PHARMACOL, V513, P145, DOI 10.1016/j.ejphar.2005.02.010
   Lewis SJ, 2008, INT J CLIN PRACT, V62, P1168, DOI 10.1111/j.1742-1241.2008.01770.x
   Li AN, 2014, NUTRIENTS, V6, P6020, DOI 10.3390/nu6126020
   Liu HT, 2020, CURR ALZHEIMER RES, V17, P105, DOI 10.2174/1567205017666200317102337
   Liu JM, 2020, PAK J PHARM SCI, V33, P437, DOI 10.36721/PJPS.2020.33.1.SP.437-440.1
   Lorente-Cebrián S, 2013, J PHYSIOL BIOCHEM, V69, P633, DOI 10.1007/s13105-013-0265-4
   Mano J, 2019, FRONT PLANT SCI, V10, DOI 10.3389/fpls.2019.00487
   Matafome P, 2017, MED RES REV, V37, P368, DOI 10.1002/med.21410
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   Menini S, 2020, CURR MED CHEM, V27, P1744, DOI 10.2174/0929867326666190711102718
   Miller ER, 2005, ANN INTERN MED, V142, P37, DOI 10.7326/0003-4819-142-1-200501040-00110
   Milman U, 2008, ARTERIOSCL THROM VAS, V28, P341, DOI 10.1161/ATVBAHA.107.153965
   Mitjavila MT, 2012, BIOCHEM PHARMACOL, V84, P1113, DOI 10.1016/j.bcp.2012.07.017
   Moldogazieva NT, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/3085756
   Mollazadeh H, 2016, IRAN J BASIC MED SCI, V19, P1258, DOI 10.22038/ijbms.2016.7906
   Momtaz S., 2010, INT J PHARMACOL, V6, P454, DOI [10.3923/ijp.2010.346.353, DOI 10.3923/IJP.2010.346.353]
   Monserrat-Mesquida M, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9030236
   Montezano AC, 2012, CAN J CARDIOL, V28, P288, DOI 10.1016/j.cjca.2012.01.017
   Moreira GC, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0105056
   Mori T, 2006, J PHARMACOL SCI, V100, P2, DOI 10.1254/jphs.FMJ05003X2
   Nagai K, 2003, EXP BIOL MED, V228, P1138, DOI 10.1177/153537020322801007
   Nerkar D., 2015, Int J Pharm Pharm Sci, V7, P22
   Neuhouser ML, 2009, ARCH INTERN MED, V169, P294, DOI 10.1001/archinternmed.2008.540
   Niki E, 2009, FREE RADICAL BIO MED, V47, P469, DOI 10.1016/j.freeradbiomed.2009.05.032
   O'Connor PM, 2016, AM J PHYSIOL-REG I, V310, pR679, DOI 10.1152/ajpregu.00115.2015
   Ota K, 2007, BIOCHEM BIOPH RES CO, V357, P270, DOI 10.1016/j.bbrc.2007.03.140
   Page M J., 2021, INT J SURG, DOI [10.1016/j.ijsu.2021.105906, DOI 10.1016/j.ijsu.2021.105906]
   Pamplona R, 2011, CHEM-BIOL INTERACT, V192, P14, DOI 10.1016/j.cbi.2011.01.007
   Park' L, 1998, NAT MED, V4, P1025, DOI 10.1038/2012
   Pennathur Subramaniam, 2007, Curr Diab Rep, V7, P257, DOI 10.1007/s11892-007-0041-3
   Peters V, 2017, J ENZYM INHIB MED CH, V32, P1102, DOI 10.1080/14756366.2017.1355793
   Pillon NJ, 2012, ENDOCRINOLOGY, V153, P2099, DOI 10.1210/en.2011-1957
   Poluzzi E, 2014, CURR MED CHEM, V21, P417
   Power M, 2011, CURR DIABETES REP, V11, P173, DOI 10.1007/s11892-011-0184-0
   Procházková D, 2011, FITOTERAPIA, V82, P513, DOI 10.1016/j.fitote.2011.01.018
   Rabbani N, 2014, DIABETES, V63, P50, DOI 10.2337/db13-1606
   Rabbani N, 2012, AMINO ACIDS, V42, P1087, DOI 10.1007/s00726-010-0782-1
   Rafiq K, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0107853
   Rahimi R, 2005, BIOMED PHARMACOTHER, V59, P365, DOI 10.1016/j.biopha.2005.07.002
   Regazzoni L, 2016, SCI REP-UK, V6, DOI 10.1038/srep27224
   Rodriguez EL, 2021, J CHROMATOGR A, V1638, DOI 10.1016/j.chroma.2020.461683
   Saeidnia S, 2013, TOXICOL APPL PHARM, V273, P442, DOI 10.1016/j.taap.2013.09.031
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Salazar-Ramiro A, 2016, FRONT IMMUNOL, V7, DOI 10.3389/fimmu.2016.00156
   Sauerhöfer S, 2007, DIABETES, V56, P2425, DOI 10.2337/db07-0177
   Savage DB, 2007, PHYSIOL REV, V87, P507, DOI 10.1152/physrev.00024.2006
   Schalkwijk CG, 2020, PHYSIOL REV, V100, P407, DOI 10.1152/physrev.00001.2019
   Semchyshyn H, 2021, PFLUG ARCH EUR J PHY, V473, P723, DOI 10.1007/s00424-021-02529-y
   Semchyshyn HM, 2014, SCI WORLD J, DOI 10.1155/2014/417842
   Sena CM, 2011, BRIT J PHARMACOL, V163, P424, DOI 10.1111/j.1476-5381.2011.01230.x
   Shao CH, 2011, DIABETES, V60, P947, DOI 10.2337/db10-1145
   Shen Yan, 2012, J Tradit Complement Med, V2, P27
   Siems Werner, 2003, Molecular Aspects of Medicine, V24, P167, DOI 10.1016/S0098-2997(03)00011-6
   Sil R, 2016, PHYTOTHER RES, V30, P1503, DOI 10.1002/ptr.5654
   Sil R, 2015, MOL CELL BIOCHEM, V409, P177, DOI 10.1007/s11010-015-2523-y
   Singh DK, 2011, NAT REV ENDOCRINOL, V7, P176, DOI 10.1038/nrendo.2010.212
   Singh R, 2001, DIABETOLOGIA, V44, P129, DOI 10.1007/s001250051591
   Tabatabaei-Malazy O, 2012, J PHARM PHARM SCI, V15, P447, DOI 10.18433/J32W29
   Taylor LE, 2018, AM J PHYSIOL-HEART C, V315, pH1713, DOI 10.1152/ajpheart.00389.2018
   Tessier FJ, 2010, PATHOL BIOL, V58, P214, DOI 10.1016/j.patbio.2009.09.014
   Thornalley PJ, 2003, BIOCHEM SOC T, V31, P1343
   Tian CJ, 2019, TRENDS ENDOCRIN MET, V30, P546, DOI 10.1016/j.tem.2019.05.005
   Tsoi B, 2011, J PHARMACOL SCI, V117, P223, DOI 10.1254/jphs.11131FP
   Uchida K, 2000, FREE RADICAL BIO MED, V28, P1685, DOI 10.1016/S0891-5849(00)00226-4
   Verma D, 2021, CUREUS J MED SCIENCE, V13, DOI 10.7759/cureus.14029
   Vistoli G, 2013, FREE RADICAL RES, V47, P3, DOI 10.3109/10715762.2013.815348
   Voziyan P, 2014, CLIN CHEM LAB MED, V52, P39, DOI 10.1515/cclm-2012-0818
   Wang HL, 2019, ANAL CHEM, V91, P5646, DOI 10.1021/acs.analchem.8b05426
   Wang QW, 2020, BIOMATER SCI-UK, V8, P3370, DOI 10.1039/d0bm00474j
   Wang X, 2014, BMJ-BRIT MED J, V349, DOI 10.1136/bmj.g4490
   Yadav UCS, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/690545
   Yamagishi S, 2011, EXP GERONTOL, V46, P217, DOI 10.1016/j.exger.2010.11.007
   Yeum KJ, 2010, AMINO ACIDS, V38, P847, DOI 10.1007/s00726-009-0291-2
   Zhu SK, 2004, METABOLISM, V53, P1503, DOI 10.1016/j.metabol.2004.04.017
   Zirnniak P, 2011, FREE RADICAL BIO MED, V51, P1087, DOI 10.1016/j.freeradbiomed.2011.05.039
NR 152
TC 11
Z9 11
U1 1
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD MAR
PY 2022
VL 27
IS 5
AR 1583
DI 10.3390/molecules27051583
PG 29
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 0A1IX
UT WOS:000773716300001
PM 35268685
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rasaee, S
   Alizadeh, M
   Kheirouri, S
   Abdollahzad, H
AF Rasaee, Sama
   Alizadeh, Mohammad
   Kheirouri, Sorayya
   Abdollahzad, Hadi
TI Does total antioxidant capacity affect the features of metabolic
   syndrome? A systematic review
SO NUTRITION & FOOD SCIENCE
LA English
DT Review
DE Blood pressure; Metabolic syndrome; Dietary total antioxidant capacity;
   Dyslipidemia; High-density lipoprotein; Insulin resistance
ID OXIDATIVE STRESS; HEALTH; RISK; DIET; DISEASE; INFLAMMATION; OBESITY
AB Purpose
   There is some evidence that suggest a higher dietary total antioxidant capacity (DTAC) is associated with a lower risk of metabolic syndrome (MetS). Considering the conflicting results in this field, this paper aims to provide a comprehensive summary of studies on the association of DTAC and components of MetS.
   Design/methodology/approach
   A systematic review of articles indexed in PubMed, Scopus and Google Scholar, published from inception to September 2018, with defined keywords, was done. Duplicate or irrelevant reports were screened out and data were extracted through critical analysis. Finally, among the 353 articles, 19 articles met the inclusion criteria.
   Findings
   The included cohort studies revealed that higher DTAC was associated with reduced risk of MetS. Also, the association between DTAC and mortality risk of MetS was insignificant in these studies. The case-control studies showed high DTAC is inversely associated with MetS, its components and complications. The randomized controlled trials found that changes in DTAC were negatively correlated with oxidized low-density lipoprotein cholesterol and there was a positive association between DTAC and subjects' weight and body mass index. Finally, results from the cross-sectional studies were inconsistence in this regard.
   Originality/value
   The assessed relationship between MetS or its components with DTAC is inconsistent in the included studies. Different sample size, dietary assessment tools, DTAC index values and geographical location may justify the observed inconsistencies. It seems that further studies are needed to reveal more confident and reliable findings.
C1 [Rasaee, Sama; Alizadeh, Mohammad; Kheirouri, Sorayya] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Tabriz, Iran.
   [Abdollahzad, Hadi] Kermanshah Univ Med Sci, Nutr Res Ctr, Fac Nutr & Food Sci, Kermanshah, Iran.
C3 Tabriz University of Medical Science; Kermanshah University of Medical
   Sciences
RP Alizadeh, M (corresponding author), Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Tabriz, Iran.
EM sama3319@yahoo.com; Md_alizadeh@yahoo.com; kheirouris@tbzmed.ac.ir;
   hadi_nut@yahoo.com
RI abdollahzad, hadi/J-9093-2017; Alizadeh, Mohammad/M-4703-2017
OI Abdollahzad, Hadi/0000-0003-2367-9573; kheirouri,
   sorayya/0000-0001-6249-4462
CR Abbasian M, 2018, DIABETES METAB SYND, V12, P497, DOI 10.1016/j.dsx.2018.03.015
   Abshirini M, 2018, NUTRITION, V55-56, P161, DOI 10.1016/j.nut.2018.04.014
   Alam MN, 2013, SAUDI PHARM J, V21, P143, DOI 10.1016/j.jsps.2012.05.002
   Andersen CJ, 2013, REV ENDOCR METAB DIS, V14, P241, DOI 10.1007/s11154-013-9251-y
   Arrigo T, 2015, WORLD J GASTROENTERO, V21, P384, DOI 10.3748/wjg.v21.i2.384
   Bagby SP, 2019, AM J PUBLIC HEALTH, V109, pS56, DOI [10.2105/ajph.2018.304864, 10.2105/AJPH.2018.304864]
   BAHADORAN Z, 2012, NUTR METAB, V9
   Booth FW, 2012, COMPR PHYSIOL, V2, P1143, DOI 10.1002/cphy.c110025
   Çapas M, 2018, PROG NUTR, V20, P67, DOI 10.23751/pn.v20i1.5243
   Chaves JO, 2019, BRIT FOOD J, V122, P606, DOI 10.1108/BFJ-05-2019-0334
   Chiva-Blanch G, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/5812401
   De Batlle J, 2010, FREE RADICAL RES, V44, P1296, DOI 10.3109/10715762.2010.500667
   de la Iglesia R, 2013, INT J MOL SCI, V14, P6903, DOI 10.3390/ijms14046903
   de Oliveira DG, 2019, EUR J NUTR, V58, P2263, DOI 10.1007/s00394-018-1776-0
   Farhangi MA, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0208806
   Förstermann U, 2010, PFLUG ARCH EUR J PHY, V459, P923, DOI 10.1007/s00424-010-0808-2
   Galbete C, 2018, EUR J EPIDEMIOL, V33, P909, DOI 10.1007/s10654-018-0427-3
   Gawron-Skarbek A, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/216964
   Georgoulis M, 2015, NUTR RES, V35, P41, DOI 10.1016/j.nutres.2014.11.004
   Grosso G, 2017, EUR J NUTR, V56, P1409, DOI 10.1007/s00394-016-1187-z
   Ham DongWoo Ham DongWoo, 2017, Journal of Nutrition and Health, V50, P246, DOI 10.4163/jnh.2017.50.3.246
   Henríquez-Sánchez P, 2016, EUR J NUTR, V55, P227, DOI 10.1007/s00394-015-0840-2
   Hermsdorff HHM, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-59
   Higgins Julian P T, 2011, BMJ, V343, pd5928, DOI 10.1136/bmj.d5928
   Hossain M. K., 2016, INT J MOL SCI, V17
   Kheirouri S, 2019, ADV NUTR, V10, P9, DOI 10.1093/advances/nmy100
   Kim K, 2018, EUR J NUTR, V57, P2469, DOI 10.1007/s00394-017-1519-7
   Kim S, 2017, NUTRIENTS, V9, DOI 10.3390/nu9101055
   Kirkpatrick SI, 2019, J ACAD NUTR DIET, V119, P1801, DOI 10.1016/j.jand.2019.06.010
   Kobayashi S, 2012, NUTR J, V11, DOI 10.1186/1475-2891-11-91
   Kong LC, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0109434
   Lei XG, 2011, ANTIOXID REDOX SIGN, V14, P489, DOI 10.1089/ars.2010.3416
   Liguori I, 2018, CLIN INTERV AGING, V13, P757, DOI 10.2147/CIA.S158513
   Lopez-Legarrea P, 2013, NUTR METAB, V10, DOI 10.1186/1743-7075-10-22
   Mancini FR, 2018, DIABETOLOGIA, V61, P308, DOI 10.1007/s00125-017-4489-7
   Mangge H, 2014, WORLD J CARDIOL, V6, P462, DOI 10.4330/wjc.v6.i6.462
   Manna P, 2015, METAB SYNDR RELAT D, V13, P423, DOI 10.1089/met.2015.0095
   Margulis AV, 2014, CLIN EPIDEMIOL, V6, P359, DOI 10.2147/CLEP.S66677
   Maslov LN, 2019, J CLIN TRANSL ENDOCR, V15, P1, DOI 10.1016/j.jcte.2018.11.001
   Minihane AM, 2015, BRIT J NUTR, V114, P999, DOI 10.1017/S0007114515002093
   Mohamed G. A., 2014, Bulletin of the Faculty of Pharmacy, Cairo University, V52, P269, DOI 10.1016/j.bfopcu.2014.05.001
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Ng R, 2020, INT J EPIDEMIOL, V49, P113, DOI 10.1093/ije/dyz078
   Okubo H, 2014, NUTR METAB CARDIOVAS, V24, P301, DOI 10.1016/j.numecd.2013.08.001
   Parohan M, 2019, CRIT REV ONCOL HEMAT, V138, P70, DOI 10.1016/j.critrevonc.2019.04.003
   Popay J., 2006, GUIDANCE CONDUCT NAR, P1, DOI DOI 10.13140/2.1.1018.4643
   Psaltopoulou T, 2011, NUTR METAB CARDIOVAS, V21, P561, DOI 10.1016/j.numecd.2009.11.005
   Puchau B, 2010, INT J FOOD SCI NUTR, V61, P713, DOI 10.3109/09637481003757860
   Qu RG, 2018, NUTRIENTS, V10, DOI 10.3390/nu10080991
   Rautiainen S, 2013, AM J MED, V126, P494, DOI 10.1016/j.amjmed.2013.01.006
   Rezaeimanesh N, 2019, NUTR FOOD SCI, V50, P653, DOI 10.1108/NFS-07-2019-0208
   Sadeghpour Y, 2020, NUTR FOOD SCI, V50, P1053, DOI 10.1108/NFS-07-2019-0237
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Shield KD, 2013, ALCOHOL RES-CURR REV, V35, P155
   Sótoudeh G, 2018, NUTRITION, V46, P20, DOI 10.1016/j.nut.2017.08.005
   Takaoka N, 2019, TOHOKU J EXP MED, V249, P65, DOI 10.1620/tjem.249.65
   Talebi S, 2019, NUTR FOOD SCI, V49, P700, DOI 10.1108/NFS-04-2018-0113
   Tripathi J. S., 2011, Journal of Applied Pharmaceutical Science, V1, P32
   Wang S, 2014, J NUTR BIOCHEM, V25, P1, DOI 10.1016/j.jnutbio.2013.09.001
   Wang Y, 2012, J ACAD NUTR DIET, V112, P1626, DOI 10.1016/j.jand.2012.06.007
   Wilson DW, 2017, ANTIOXIDANTS-BASEL, V6, DOI 10.3390/antiox6040081
   Witkowska AM, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/5982809
   Witztum JL, 2001, TRENDS CARDIOVAS MED, V11, P93, DOI 10.1016/S1050-1738(01)00111-6
   Zou CY, 2020, INT J DIABETES DEV C, V40, P235, DOI 10.1007/s13410-019-00794-3
   Zujko ME, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/7487816
   Zulueta A, 2009, FOOD CHEM, V114, P310, DOI 10.1016/j.foodchem.2008.09.033
NR 66
TC 7
Z9 7
U1 0
U2 9
PU EMERALD GROUP PUBLISHING LTD
PI Leeds
PA Floor 5, Northspring 21-23 Wellington Street, Leeds, W YORKSHIRE,
   ENGLAND
SN 0034-6659
EI 1758-6917
J9 NUTR FOOD SCI
JI Nutr. Food Sci.
PD JAN 27
PY 2021
VL 51
IS 1
BP 100
EP 113
DI 10.1108/NFS-01-2020-0031
EA MAY 2020
PG 14
WC Food Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Food Science & Technology
GA PZ9ZR
UT WOS:000532268800001
DA 2025-06-11
ER

PT J
AU Tamtaji, OR
   Milajerdi, A
   Dadgostar, E
   Kolandooz, F
   Chamani, M
   Amirani, E
   Mirzaei, H
   Asemi, Z
AF Tamtaji, Omid R.
   Milajerdi, Alireza
   Dadgostar, Ehsan
   Kolandooz, Fariba
   Chamani, Maryam
   Amirani, Elaheh
   Mirzaei, Hamed
   Asemi, Zatollah
TI The Effects of Quercetin Supplementation on Blood Pressures and
   Endothelial Function Among Patients with Metabolic Syndrome and Related
   Disorders: A Systematic Review and Meta-analysis of Randomized
   Controlled Trials
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Quercetin; blood pressures; endothelial function; meta-analysis;
   randomized controlled trials; metabolic syndrome
ID ADHESION MOLECULE EXPRESSION; LOW-DENSITY-LIPOPROTEIN; ONION SKIN
   EXTRACT; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; DOUBLE-BLIND;
   KAPPA-B; DYSFUNCTION; INHIBITION; MEN
AB Background: This systematic review and meta-analysis of randomized controlled trials (RCTs) were performed to determine the effect of quercetin administration on blood pressures and endothelial function among patients with metabolic syndrome (MetS) and related disorders.
   Methods: We searched systematically online databases including Cochrane Library. EMBASE, MEDLINE, and Web of Science to identify the relevant RCTs until December 2018. Q-test and I-2 statistics were applied to assess heterogeneity among the included studies. Data were pooled using a random-effects model and weighted mean difference (WMD) was considered as the overall effect size.
   Results: Out of 284 citations, 8 RCTs were included in the meta-analysis. We found a significant reduction in systolic blood pressure (SBP) (WMD: -1.69; 95% CI: -3.22, -0.17) following the intake of quercetin supplements. However, quercetin supplementation did not significantly affect diastolic blood pressure (DBP) (WMD: -3.14; 95% CI: -8.24, 1.95), vascular cell adhesion molecule 1 (VCAM-1) (WMD: -24.49; 95% CI: -53.74, 4.77) and intercellular adhesion molecule 1 (ICAM-1) (WMD: -5.78; 95% CI: -12.93, 1.38).
   Conclusion: In summary, the current meta-analysis demonstrated that quercetin supplementation significantly reduced SBP, yet did not affect DBP, VCAM-1 and ICAM-1 among patients with MetS and related disorders.
C1 [Tamtaji, Omid R.; Amirani, Elaheh; Mirzaei, Hamed; Asemi, Zatollah] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
   [Milajerdi, Alireza] Univ Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran.
   [Milajerdi, Alireza] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Dadgostar, Ehsan] FDA, Halal Res Ctr IRI, Tehran, Iran.
   [Kolandooz, Fariba] Univ Alberta, Dept Med, Indigenous & Global Hlth Res, Edmonton, AB, Canada.
   [Chamani, Maryam] Iran Univ Med Sci, Sch Med, Dept Gynecol & Obstet, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; University of Alberta; Iran University of Medical Sciences
RP Asemi, Z (corresponding author), Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
EM asemi_r@yahoo.com
RI tamtaji, M/KWU-3655-2024; Milajerdi, Alireza/ABB-1854-2020; Asemi,
   Zatollah/G-7393-2017; Chamani, Maryam/Y-3396-2019
OI Tamtaji, Omid Reza/0000-0003-2492-3996; dadgostar,
   ehsan/0000-0002-4041-7324
FU Kashan University of Medical Sciences (KAUMS) [97201]
FX The research grant (97201) was provided by the Research Deputy of Kashan
   University of Medical Sciences (KAUMS).
CR Atkins GB, 2011, ARTERIOSCL THROM VAS, V31, P1476, DOI 10.1161/ATVBAHA.111.228999
   Barona J, 2012, J NUTR, V142, P1626, DOI 10.3945/jn.112.162743
   BERGMARK C, 1995, ARTERIOSCL THROM VAS, V15, P441, DOI 10.1161/01.ATV.15.4.441
   Bhaskar S, 2016, CELL IMMUNOL, V310, P131, DOI 10.1016/j.cellimm.2016.08.011
   Biesinger S, 2016, EUR J CLIN NUTR, V70, P10, DOI 10.1038/ejcn.2015.88
   Boyer J, 2004, J AGR FOOD CHEM, V52, P7172, DOI 10.1021/jf030733d
   Brüll V, 2017, EUR J NUTR, V56, P1347, DOI 10.1007/s00394-016-1185-1
   Bruell V, 2015, BRIT J NUTR, V114, P1263, DOI 10.1017/S0007114515002950
   Chen P, 2012, INT J MOL MED, V30, P119, DOI 10.3892/ijmm.2012.955
   Clifton PM, 2004, J BIOMED BIOTECHNOL, P272, DOI 10.1155/S1110724304403088
   Dharmashankar K, 2010, CURR HYPERTENS REP, V12, P448, DOI 10.1007/s11906-010-0150-2
   Duarte J, 2001, BRIT J PHARMACOL, V133, P117, DOI 10.1038/sj.bjp.0704064
   Edwards RL, 2007, J NUTR, V137, P2405, DOI 10.1093/jn/137.11.2405
   Egert S, 2010, J NUTR, V140, P278, DOI 10.3945/jn.109.117655
   Egert S, 2009, BRIT J NUTR, V102, P1065, DOI 10.1017/S0007114509359127
   Félétou M, 2010, CURR HYPERTENS REP, V12, P267, DOI 10.1007/s11906-010-0118-2
   Förstermann U, 2017, CIRC RES, V120, P713, DOI 10.1161/CIRCRESAHA.116.309326
   Frostegård J, 2003, CLIN SCI, V105, P615, DOI 10.1042/CS20030152
   Häckl LPN, 2002, PHARMACOLOGY, V65, P182, DOI 10.1159/000064341
   Higashi Y, 2014, TRENDS CARDIOVAS MED, V24, P165, DOI 10.1016/j.tcm.2013.12.001
   Hung CH, 2015, MOL NUTR FOOD RES, V59, P1905, DOI 10.1002/mnfr.201500144
   Kim Kyung-Ah, 2015, J Cancer Prev, V20, P202, DOI 10.15430/JCP.2015.20.3.202
   Korsholm AS, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18030554
   Lotito SB, 2006, J BIOL CHEM, V281, P37102, DOI 10.1074/jbc.M606804200
   Mackraj I, 2008, J CARDIOVASC PHARM, V51, P239, DOI 10.1097/FJC.0b013e318162011f
   Mamani-Matsuda M, 2006, BIOCHEM PHARMACOL, V72, P1304, DOI 10.1016/j.bcp.2006.08.001
   Panicker SR, 2010, PHARMACOL RES, V62, P328, DOI 10.1016/j.phrs.2010.06.003
   Peet GW, 1999, J BIOL CHEM, V274, P32655, DOI 10.1074/jbc.274.46.32655
   Perez-Vizcaino F, 2006, FREE RADICAL RES, V40, P1054, DOI 10.1080/10715760600823128
   Pfeuffer M, 2013, NUTR METAB CARDIOVAS, V23, P403, DOI 10.1016/j.numecd.2011.08.010
   Sánchez M, 2006, J HYPERTENS, V24, P75, DOI 10.1097/01.hjh.0000198029.22472.d9
   Sanders RA, 2001, J BIOCHEM MOL TOXIC, V15, P143, DOI 10.1002/jbt.11
   Schulz E, 2011, HYPERTENS RES, V34, P665, DOI 10.1038/hr.2011.39
   Serban MC, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.115.002713
   Tribolo S, 2008, ATHEROSCLEROSIS, V197, P50, DOI 10.1016/j.atherosclerosis.2007.07.040
   Valente AJ, 2014, FREE RADICAL BIO MED, V70, P117, DOI 10.1016/j.freeradbiomed.2014.02.014
   van den Hoogen PCW, 2000, NEW ENGL J MED, V342, P1, DOI 10.1056/NEJM200001063420101
   Wong ND, 2003, AM J CARDIOL, V91, P1421, DOI 10.1016/S0002-9149(03)00392-8
   Yoshizumi M, 2002, BIOCHEM BIOPH RES CO, V293, P1458, DOI 10.1016/S0006-291X(02)00407-2
   Zahedi M, 2013, INT J PREVENTIVE MED, V4, P777
NR 40
TC 25
Z9 25
U1 2
U2 10
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2019
VL 25
IS 12
BP 1372
EP 1384
DI 10.2174/1381612825666190513095352
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IQ0AU
UT WOS:000480413100002
PM 31092175
DA 2025-06-11
ER

PT J
AU Ebrahimi-Mameghani, M
   Asghari-Jafarabadi, M
   Rezazadeh, K
AF Ebrahimi-Mameghani, Mehranghiz
   Asghari-Jafarabadi, Mohammad
   Rezazadeh, Khatereh
TI TCF7L2-rs7903146 polymorphism modulates the effect of artichoke leaf
   extract supplementation on insulin resistance in metabolic syndrome: a
   randomized, double-blind, placebo-controlled trial
SO JOURNAL OF INTEGRATIVE MEDICINE-JIM
LA English
DT Article
DE Metabolic syndrome; Artichoke leaf extract; Transcription factor 7-like
   2; Insulin; Insulin resistance; Alternative and complementary medicine;
   Diabetes
ID CYNARA-SCOLYMUS L.; BETA-CELL FUNCTION; PLASMA-CHOLESTEROL; OXIDATIVE
   STRESS; GENETIC-VARIANTS; CLINICAL-TRIAL; IN-VIVO; TCF7L2; RISK;
   PRETREATMENT
AB Background: Transcription factor 7-like 2 (TCF7L2)-rs7903146 polymorphism is associated with increased risk of type 2 diabetes. The response of insulin and insulin resistance to artichoke leaf extract (ALE) may be affected by TCF7L2-rs7903146 polymorphism.
   Objective: This study examined the effects of ALE supplementation on metabolic parameters of the TCF7L2-rs7903146 polymorphism in patients with metabolic syndrome (MetS).
   Design, setting, participants and interventions: This double-blind clinical trial was conducted on 80 patients with MetS in Sina Clinic, Khoy, Iran. The patients were randomized into ALE or placebo groups to receive either ALE (1800 mg/d as four tablets) or matching placebo for 12 weeks.
   Main outcome measures: Anthropometric indices, blood pressure, glucose and lipid profile levels were measured before and after the study. Moreover, patients were genotyped for TCF7L2 polymorphism.
   Results: ALE supplementation decreased insulin level and the homeostasis model assessment of insulin resistance (HOMA-IR) in patients with the TT genotype of TCF7L2-rs7903146 polymorphism (P < 0.05). There was no significant interaction between blood pressure, glucose and lipid profile response to ALE supplementation.
   Conclusion: The responses of insulin and HOMA-IR to ALE supplementation have shown an interaction with single-nucleotide polymorphism rs7903146 in TCF7L2. (C) 2018 Shanghai Changhai Hospital. Published by Elsevier B.V. All rights reserved.
C1 [Ebrahimi-Mameghani, Mehranghiz; Rezazadeh, Khatereh] Tabriz Univ Med Sci, Sch Nutr & Food Sci, Nutr Res Ctr, Tabriz 5166614711, Iran.
   [Asghari-Jafarabadi, Mohammad] Tabriz Univ Med Sci, Rd Traff Injury Res Ctr, Tabriz 5166614711, Iran.
   [Asghari-Jafarabadi, Mohammad] Tabriz Univ Med Sci, Sch Hlth, Dept Stat & Epidemiol, Tabriz 5166614711, Iran.
   [Rezazadeh, Khatereh] Tabriz Univ Med Sci, Sch Nutr & Food Sci, Student Res Comm, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Tabriz University of
   Medical Science
RP Rezazadeh, K (corresponding author), Tabriz Univ Med Sci, Sch Nutr & Food Sci, Nutr Res Ctr, Tabriz 5166614711, Iran.
EM rezazadekhatere@gmail.com
RI Rezazadeh, Khatereh/N-2488-2019; Asghari Jafarabadi,
   Mohammmad/A-7478-2017
OI Asghari Jafarabadi, Mohammmad/0000-0003-3284-9749; rezazadeh,
   khatereh/0000-0002-9270-7788
FU Research Vice Chancellor, Tabriz University of Medical Sciences, Tabriz,
   Iran [5/97/4653]
FX We are grateful to the subjects who have contributed in this study. We
   also would like to acknowledge Dineh Iran. Co. for preparing of ALE and
   placebo tablets. This study was supported by a Grant from the Research
   Vice Chancellor, Tabriz University of Medical Sciences, Tabriz, Iran
   (grant number: 5/97/4653). The results of this article are derived from
   the Ph.D. thesis of Khatereh Rezazadeh (NO, D/41).
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Arion WJ, 1997, ARCH BIOCHEM BIOPHYS, V339, P315, DOI 10.1006/abbi.1996.9874
   Azizi F, 2010, ARCH IRAN MED, V13, P426, DOI 010135/AIM.0011
   Ben Salem M, 2015, PLANT FOOD HUM NUTR, V70, P441, DOI 10.1007/s11130-015-0503-8
   Bundy R, 2008, PHYTOMEDICINE, V15, P668, DOI 10.1016/j.phymed.2008.03.001
   Corella D, 2013, DIABETES CARE, V36, P3803, DOI 10.2337/dc13-0955
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   Cropano C, 2017, DIABETES CARE, V40, P1082, DOI 10.2337/dc17-0290
   Eckel RH, 2010, LANCET, V375, P181, DOI 10.1016/S0140-6736(09)61794-3
   Englisch W, 2000, ARZNEIMITTELFORSCH, V50, pE260
   Finniss DG, 2010, LANCET, V375, P686, DOI 10.1016/S0140-6736(09)61706-2
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Gebhardt R, 2002, PHYTOTHER RES, V16, P368, DOI 10.1002/ptr.960
   Holtmann G, 2003, ALIMENT PHARM THER, V18, P1099, DOI 10.1046/j.1365-2036.2003.01767.x
   Ihaka R., 1996, J COMPUTATIONAL GRAP, V5, P299, DOI [10.2307/1390807, DOI 10.1080/10618600.1996.10474713]
   IPAQ Research Committee, 2005, Guidelines for data processing and analysis of the international physical activity questionnaire (IPAQ)-Short and long forms
   Küçükgergin C, 2010, BIOL TRACE ELEM RES, V135, P264, DOI 10.1007/s12011-009-8484-9
   Lyssenko V, 2007, J CLIN INVEST, V117, P2155, DOI 10.1172/JCI30706
   Marzi C, 2007, HORM METAB RES, V39, P46, DOI 10.1055/s-2007-957345
   Matsui T, 2006, MINI-REV MED CHEM, V6, P349, DOI 10.2174/138955706776073484
   Mattei J, 2012, AM J CLIN NUTR, V96, P1129, DOI 10.3945/ajcn.112.038125
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mehmetçik G, 2008, EXP TOXICOL PATHOL, V60, P475, DOI 10.1016/j.etp.2008.04.014
   Melzer D, 2006, BMC MED, V4, DOI 10.1186/1741-7015-4-34
   Mora S, 2009, CLIN CHEM, V55, P888, DOI 10.1373/clinchem.2008.117929
   Parra EJ, 2007, CLIN GENET, V71, P359, DOI 10.1111/j.1399-0004.2007.00780.x
   Petrowicz O, 1997, ATHEROSCLEROSIS, V129, P41
   Povel CM, 2011, OBES REV, V12, P952, DOI 10.1111/j.1467-789X.2011.00907.x
   Qiang ZY, 2012, PHYTOTHER RES, V26, P1048, DOI 10.1002/ptr.3698
   Rezazadeh K, 2018, EUR J INTEGR MED, V17, P112, DOI 10.1016/j.eujim.2017.12.008
   Rezazadeh K, 2018, CLIN NUTR, V37, P790, DOI 10.1016/j.clnu.2017.03.017
   Rezazadeh K, 2018, PHYTOTHER RES, V32, P84, DOI 10.1002/ptr.5951
   Rondanelli M, 2014, PHYTOTHER RES, V28, P33, DOI 10.1002/ptr.4950
   Rondanelli M, 2013, INT J FOOD SCI NUTR, V64, P7, DOI 10.3109/09637486.2012.700920
   Rondanelli M, 2011, PHYTOTHER RES, V25, P1275, DOI 10.1002/ptr.3425
   Shah M, 2016, DIABETES, V65, P371, DOI 10.2337/db15-1233
   Shimoda H, 2003, BIOORG MED CHEM LETT, V13, P223, DOI 10.1016/S0960-894X(02)00889-2
   Suzuki T, 2016, J ENDOCRINOL INVEST, V39, P1337, DOI 10.1007/s40618-016-0538-1
   Turkalp Isik, 2005, Anadolu Kardiyol Derg, V5, P13
   Warodomwichit D, 2009, J NUTR, V139, P439, DOI 10.3945/jn.108.096461
   Wittemer SM, 2005, PHYTOMEDICINE, V12, P28, DOI 10.1016/j.phymed.2003.11.002
   Yi FH, 2005, J BIOL CHEM, V280, P1457, DOI 10.1074/jbc.M411487200
   Zan MA, 2013, J FOOD SCI, V78, pT367, DOI 10.1111/1750-3841.12034
   Zhu XF, 2004, J AGR FOOD CHEM, V52, P7272, DOI 10.1021/jf0490192
   Zimdahl H, 2014, DIABETOLOGIA, V57, P1869, DOI 10.1007/s00125-014-3276-y
NR 46
TC 29
Z9 29
U1 1
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2095-4964
J9 J INTEGR MED-JIM
JI J. Integr. Med.-JIM
PD SEP
PY 2018
VL 16
IS 5
BP 329
EP 334
DI 10.1016/j.joim.2018.05.006
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA GS2BV
UT WOS:000443346100005
PM 30177026
DA 2025-06-11
ER

PT J
AU Chao, PM
   Kuo, YH
   Lin, YS
   Chen, CH
   Chen, SW
   Kuo, YH
AF Chao, Pei-Min
   Kuo, Yueh-Hsiung
   Lin, Yu-Shun
   Chen, Chi-Hua
   Chen, Shiow-Wen
   Kuo, Yao-Haur
TI The Metabolic Benefits of Polygonum hypoleucum Ohwi in HepG2
   Cells and Wistar Rats under Lipogenic Stress
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE Acetyl-CoA carboxylase; P. hypoleucum Ohwl; lipogenic condition;
   metabolic syndrome
ID TRIGLYCERIDE TRANSFER PROTEIN; ACETYL-COA CARBOXYLASE; HEPATIC
   INSULIN-RESISTANCE; FATTY-ACID OXIDATION; FRUCTOSE-FED HAMSTER;
   HEPATOCYTE APO-B; GENE-EXPRESSION; FISH-OIL; MICE; SECRETION
AB Inhibition of acetyl-CoA carboxylase (ACC) is one approach used for treating metabolic syndrome. Using partially purified ACC to screen herbs commonly used in Taiwanese folk medicine, we previously showed that an ethanol extract of Polygonum hypoleucum Ohwi (EP) had potent ACC inhibitory activity and partially alleviated metabolic disorders induced by a high fat diet. Since ACC plays a crucial role in de novo lipogenesis, the favorable effects of EP on metabolism were tested under lipogenic conditions in the present study. On incubating high glucose (30 mM)-stimulated HepG2 cells with EP (72.5 or 145 mu g/mL), ACC and fatty acid synthase activity, triacylglycerol content, and microsomal triacylglycerol transfer protein mRNA levels were all significantly reduced (P < 0.05, vs vehicle). When EP was given at low, medium, and high dosages (94, 188, and 470 mg/kg) to sucrose water-treated Wistar rats for four weeks, alleviation of symptoms associated with metabolic syndrome, including obesity, insulin resistance, hypertriglyceridemia, and hypertension, accompanied by hepatic ACC inactivation, was seen in the low dosage group. Four compounds (emodin, emodin-8-O-beta-D-glucopyranoside, (+)-catechin, and (-)-epicatechin) isolated from EP were identified as ACC inhibitors. These results confirm that P. hypoleucum Ohwi, acting partly through ACC inhibition, has favorable effects in alleviating metabolic disturbances occurring under lipogenic conditions.
C1 [Chao, Pei-Min; Lin, Yu-Shun] China Med Univ, Inst Nutr, Taichung 404, Taiwan.
   [Kuo, Yueh-Hsiung] China Med Univ, Tsuzuki Inst Tradit Med, Taichung 404, Taiwan.
   [Kuo, Yueh-Hsiung] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan.
   [Kuo, Yueh-Hsiung] Acad Sinica, Taipei 115, Taiwan.
   [Chen, Chi-Hua; Chen, Shiow-Wen] Food Ind Res Dev Inst, Hsinchu 300, Taiwan.
   [Kuo, Yao-Haur] Natl Res Inst Chinese Med, Taipei 112, Taiwan.
C3 China Medical University Taiwan; China Medical University Taiwan;
   National Taiwan University; Academia Sinica - Taiwan; National Research
   Institute of Chinese Medicine
RP Chao, PM (corresponding author), China Med Univ, Inst Nutr, Taichung 404, Taiwan.
EM pmchao@mail.cmu.edu.tw
RI chao, P/GSD-8001-2022
OI Chao, Pei-Min/0000-0002-4846-3245
CR Abu-Elheiga L, 2001, SCIENCE, V291, P2613, DOI 10.1126/science.1056843
   Aguilera AA, 2004, J NUTR BIOCHEM, V15, P350, DOI 10.1016/j.jnutbio.2003.12.008
   Au WS, 2003, DIABETES, V52, P1073, DOI 10.2337/diabetes.52.5.1073
   Borradaile NM, 2003, BIOCHEMISTRY-US, V42, P1283, DOI 10.1021/bi026731o
   Carpentier A, 2002, J BIOL CHEM, V277, P28795, DOI 10.1074/jbc.M204568200
   Chen CH, 2009, METABOLISM, V58, P1297, DOI 10.1016/j.metabol.2009.04.012
   Chen GC, 2011, METABOLISM, V60, P155, DOI 10.1016/j.metabol.2009.12.002
   Choi CS, 2007, P NATL ACAD SCI USA, V104, P16480, DOI 10.1073/pnas.0706794104
   Dong H, 2005, WORLD J GASTROENTERO, V11, P1339, DOI 10.3748/wjg.v11.i9.1339
   El Hafidi M, 2001, J NUTR BIOCHEM, V12, P396, DOI 10.1016/S0955-2863(01)00154-1
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   Harwood H James Jr, 2004, Curr Opin Investig Drugs, V5, P283
   Harwood HJ, 2003, J BIOL CHEM, V278, P37099, DOI 10.1074/jbc.M304481200
   Hasty AH, 2000, J BIOL CHEM, V275, P31069, DOI 10.1074/jbc.M003335200
   Hussain MM, 2008, CURR OPIN LIPIDOL, V19, P277, DOI 10.1097/MOL.0b013e3282feea85
   Kawasaki T, 2005, BRIT J NUTR, V93, P613, DOI 10.1079/BJN20051407
   KREGE JH, 1995, HYPERTENSION, V25, P1111, DOI 10.1161/01.HYP.25.5.1111
   Kuo YC, 1997, LIFE SCI, V61, P2335, DOI 10.1016/S0024-3205(97)00937-5
   Kuo YC, 2001, LIFE SCI, V68, P1271, DOI 10.1016/S0024-3205(00)01033-X
   Kuo YC, 2001, INFLAMM RES, V50, P73, DOI 10.1007/s000110050727
   KUO YC, 1996, J CHINESE MED, V7, P119
   LIN MCM, 1995, J LIPID RES, V36, P1073
   MCCUNE SA, 1979, J BIOL CHEM, V254, P95
   Miyazaki M, 2007, CELL METAB, V6, P484, DOI 10.1016/j.cmet.2007.10.014
   Munday MR, 2002, BIOCHEM SOC T, V30, P1059, DOI 10.1042/bst0301059
   Nakajima K, 2000, J BIOL CHEM, V275, P20880, DOI 10.1074/jbc.M905410199
   Nerurkar PV, 2005, J NUTR, V135, P702, DOI 10.1093/jn/135.4.702
   Plutzky J, 2000, CURR OPIN CARDIOL, V15, P416, DOI 10.1097/00001573-200011000-00008
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Savage DB, 2006, J CLIN INVEST, V116, P817, DOI 10.1172/JCI27300
   Taghibiglou C, 2000, J BIOL CHEM, V275, P8416, DOI 10.1074/jbc.275.12.8416
   Tanabe T, 1981, Methods Enzymol, V71 Pt C, P5
   Tong L, 2005, CELL MOL LIFE SCI, V62, P1784, DOI 10.1007/s00018-005-5121-4
   WAKIL SJ, 1983, ANNU REV BIOCHEM, V52, P537, DOI 10.1146/annurev.bi.52.070183.002541
   Watanabe J, 1998, BIOSCI BIOTECH BIOCH, V62, P532, DOI 10.1271/bbb.62.532
   Wilcox LJ, 2001, J LIPID RES, V42, P725
   Yamashita H, 2001, P NATL ACAD SCI USA, V98, P9116, DOI 10.1073/pnas.161284298
   Yamazaki T, 2007, HEPATOLOGY, V46, P1779, DOI 10.1002/hep.21934
   Zang MW, 2004, J BIOL CHEM, V279, P47898, DOI 10.1074/jbc.M408149200
NR 39
TC 18
Z9 19
U1 0
U2 9
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD APR 28
PY 2010
VL 58
IS 8
BP 5174
EP 5180
DI 10.1021/jf100046h
PG 7
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA 584VR
UT WOS:000276782100091
PM 20230058
DA 2025-06-11
ER

PT J
AU Mondal, S
   Barman, P
   Vignesh, P
AF Mondal, Sanjib
   Barman, Prabal
   Vignesh, Pandiarajan
TI Cardiovascular Abnormalities in Juvenile Dermatomyositis: A Scoping
   Review for the Clinical Rheumatologists
SO FRONTIERS IN MEDICINE
LA English
DT Review
DE dermatomyositis; vasculopathy; cardiac dysfunction; acute; long-term;
   screening; imaging
ID IDIOPATHIC INFLAMMATORY MYOPATHIES; CARDIAC INVOLVEMENT; DIASTOLIC
   DYSFUNCTION; METABOLIC SYNDROME; POLYMYOSITIS; HEART; RISK; DIAGNOSIS;
   CHILDREN; MYOSITIS
AB Juvenile dermatomyositis (JDM) is a common form of inflammatory myositis in children. Vasculopathy and endothelial dysfunction play significant roles in the pathogenesis of JDM. Cardiac involvement in JDM is often underestimated, and it may be a potential indicator of poor prognosis. Cardiac dysfunction in JDM can occur both in the acute and chronic stages of the disease. Amongst the acute complications, acute congestive heart failure (CHF), myocarditis, arrhythmia, and complete heart block are common. However, these remain unrecognized due to a lack of overt clinical manifestations. Increased rates of cardiovascular abnormalities have been noted with anti-SRP and anti-Jo 1 auto-antibody positivity. Long-term follow-up studies in JDM have shown an increased prevalence of hypertension, atherosclerosis, coronary artery disease, and metabolic syndrome in adolescence and adulthood. Monitoring of body-mass index, blood pressure, and laboratory evaluation of fasting glucose and lipid profile may help in identifying metabolic syndrome in children with JDM. Steroid-sparing agents, daily exercise, and a healthy diet may reduce such long-term cardiac morbidities. Current use of multimodality imaging such as stress-echocardiography, contrast-enhanced echocardiography, cardiac magnetic resonance imaging, and positron emission tomography has increased the diagnostic yield of subclinical heart disease during acute and chronic stages of JDM. This review elaborates on different aspects of cardiac dysfunction in JDM. It also emphasizes the importance of cardiac screening in long-term follow-up of children with JDM.
C1 [Mondal, Sanjib; Barman, Prabal; Vignesh, Pandiarajan] Post Grad Inst Med Educ & Res, Adv Pediat Ctr, Dept Pediat, Allergy Immunol Unit, Chandigarh, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh
RP Vignesh, P (corresponding author), Post Grad Inst Med Educ & Res, Adv Pediat Ctr, Dept Pediat, Allergy Immunol Unit, Chandigarh, India.
EM vigimmc@gmail.com
RI Barman, Prabal/LRU-1928-2024
OI Barman, Prabal/0000-0002-0171-668X
CR Aeschlimann FA, 2018, BRAIN, V141, DOI 10.1093/brain/awy255
   Aggarwal R, 2009, J RHEUMATOL, V36, P2711, DOI 10.3899/jrheum.090562
   Albanese CV, 2003, J CLIN DENSITOM, V6, P75, DOI 10.1385/JCD:6:2:75
   Albayda J, 2018, SEMIN ARTHRITIS RHEU, V47, P552, DOI 10.1016/j.semarthrit.2017.06.004
   Asi K, 2019, PEDIATR RHEUMATOL, V17, DOI 10.1186/s12969-019-0304-y
   Baechler EC, 2007, MOL MED, V13, P59, DOI 10.2119/2006-00085.Baechler
   Balanescu AR, 2019, EXP THER MED, V17, P1024, DOI 10.3892/etm.2018.6992
   BANKER BQ, 1966, MEDICINE, V45, P261, DOI 10.1097/00005792-196607000-00001
   Barsalou J, 2013, ARTHRITIS RES THER, V15, DOI 10.1186/ar4212
   Barth Z, 2016, RHEUMATOLOGY, V55, P535, DOI 10.1093/rheumatology/kev376
   Betteridge Z, 2019, J AUTOIMMUN, V101, P48, DOI 10.1016/j.jaut.2019.04.001
   BOHAN A, 1975, NEW ENGL J MED, V292, P344, DOI 10.1056/NEJM197502132920706
   Bohr AH, 2015, PEDIATR RHEUMATOL, V13, DOI 10.1186/s12969-015-0053-5
   Buchpiguel CA, 1996, EUR J NUCL MED, V23, P199, DOI 10.1007/BF01731845
   Caforio ALP, 2017, EUR HEART J, V38, P2649, DOI 10.1093/eurheartj/ehx321
   Canter CE, 2014, CIRCULATION, V129, P115, DOI 10.1161/CIRCULATIONAHA.113.001372
   Cantez S, 2017, PEDIATR RHEUMATOL, V15, DOI 10.1186/s12969-017-0182-0
   Charles-Schoeman C, 2012, CLIN RHEUMATOL, V31, P1163, DOI 10.1007/s10067-012-1986-4
   Chatre C, 2018, DRUG SAFETY, V41, P919, DOI 10.1007/s40264-018-0689-4
   Cignarella A, 2006, PHARMACOL RES, V53, P492, DOI 10.1016/j.phrs.2006.03.012
   Coyle K, 2009, J PEDIATR-US, V155, P882, DOI 10.1016/j.jpeds.2009.06.009
   CROWE WE, 1982, ARTHRITIS RHEUM-US, V25, P126, DOI 10.1002/art.1780250203
   Danieli MG, 2016, AUTOIMMUN REV, V15, P462, DOI 10.1016/j.autrev.2016.01.015
   Dankó K, 2004, MEDICINE, V83, P35, DOI 10.1097/01.md.0000109755.65914.5e
   de Oliveira DS, 2019, CLIN RHEUMATOL, V38, P3435, DOI 10.1007/s10067-019-04738-4
   Dhesi S, 2013, J INVEST MED HIGH IM, V1, DOI 10.1177/2324709613480346
   Diniz MDR, 2021, CLIN RHEUMATOL, V40, P1497, DOI 10.1007/s10067-020-05418-4
   Dobloug GC, 2015, SEMIN ARTHRITIS RHEU, V45, P301, DOI 10.1016/j.semarthrit.2015.06.005
   Dogan P, 2015, INTRACTABLE RARE DIS, V4, P207, DOI 10.5582/irdr.2015.01033
   Eimer MJ, 2011, J PEDIATR-US, V159, P795, DOI 10.1016/j.jpeds.2011.05.015
   Enders FB, 2017, ANN RHEUM DIS, V76, P329, DOI 10.1136/annrheumdis-2016-209247
   Erlacher P, 2001, CLIN CHIM ACTA, V306, P27, DOI 10.1016/S0009-8981(01)00392-8
   Fall N, 2005, ARTHRITIS RHEUM-US, V52, P3175, DOI 10.1002/art.21303
   Faustino A, 2014, BMC CARDIOVASC DISOR, V14, DOI 10.1186/1471-2261-14-2
   Feldman BM, 2008, LANCET, V371, P2201, DOI 10.1016/S0140-6736(08)60955-1
   Grillo TG, 2021, WORLD J CLIN CASES, V9, P10382, DOI [10.1299841/wjcc/v.i31.10382, 10.12998/wjcc.v9.i33.10382]
   HAUPT HM, 1982, AM J CARDIOL, V50, P998, DOI 10.1016/0002-9149(82)90408-8
   Hengstman GJD, 2002, J NEUROL, V249, P69, DOI 10.1007/PL00007850
   Hornung T, 2014, NEW ENGL J MED, V371, P2537, DOI 10.1056/NEJMc1412997
   Huber AM, 2014, ARTHRIT CARE RES, V66, P732, DOI 10.1002/acr.22212
   Huemer C, 2001, J RHEUMATOL, V28, P610
   Hughes M, 2015, ANN RHEUM DIS, V74, P795, DOI 10.1136/annrheumdis-2014-206812
   Inukai T, 1983, Nihon Naika Gakkai Zasshi, V72, P423
   Karaca NE, 2006, RHEUMATOL INT, V27, P179, DOI 10.1007/s00296-006-0191-7
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Kurasawa K, 2018, RHEUMATOLOGY, V57, P2114, DOI 10.1093/rheumatology/key188
   Labirua-Iturburu A, 2012, MEDICINE, V91, P206, DOI 10.1097/MD.0b013e318260977c
   Lee JL, 2018, ARTHRITIS RES THER, V20, DOI 10.1186/s13075-018-1669-x
   Liu XH, 2020, ANN PALLIAT MED, V9, P2256, DOI 10.21037/apm-19-650
   Lu Z, 2013, J RHEUMATOL, V40, P1572, DOI 10.3899/jrheum.130044
   Maisch B, 2018, HERZ, V43, P423, DOI 10.1007/s00059-018-4719-x
   Mammen AL, 2011, ARTHRITIS RHEUM-US, V63, P713, DOI 10.1002/art.30156
   Mathiesen PR, 2013, RHEUMATOLOGY, V52, P287, DOI 10.1093/rheumatology/kes232
   Mavrogeni S, 2018, INT J CARDIOL, V252, P216, DOI 10.1016/j.ijcard.2017.11.032
   Mendez EP, 2003, ARTHRIT RHEUM-ARTHR, V49, P300, DOI 10.1002/art.11122
   Moghadam-Kia S, 2019, RHEUMATOLOGY, V58, P1011, DOI 10.1093/rheumatology/key366
   Mohassel P, 2013, CURR OPIN RHEUMATOL, V25, P747, DOI 10.1097/01.bor.0000434673.85515.89
   Moneta GM, 2019, ARTHRITIS RHEUMATOL, V71, P1011, DOI 10.1002/art.40800
   Mugii N, 2018, RHEUMATOL INT, V38, P1443, DOI 10.1007/s00296-018-4050-0
   Na SJ, 2009, J KOREAN MED SCI, V24, P715, DOI 10.3346/jkms.2009.24.4.715
   Oppenheim H, 1899, Berl Klin Wochenschr, V36, P805
   PACHMAN LM, 1980, J PEDIATR-US, V96, P226, DOI 10.1016/S0022-3476(80)80807-9
   Papadopoulou C, 2019, BRAIN, V142, DOI 10.1093/brain/awz005
   Pau-Charles I, 2014, J EUR ACAD DERMATOL, V28, P1097, DOI 10.1111/jdv.12300
   PEREIRA RMR, 1992, CLIN CARDIOL, V15, P301, DOI 10.1002/clc.4960150415
   Pereira T, 2015, J MED BIOL ENG, V35, P555, DOI 10.1007/s40846-015-0086-8
   Pujades-Rodriguez M, 2020, PLOS MED, V17, DOI 10.1371/journal.pmed.1003432
   Radmard AR, 2016, JPN J RADIOL, V34, P414, DOI 10.1007/s11604-016-0540-8
   Ravelli A, 2010, ARTHRIT CARE RES, V62, P63, DOI 10.1002/acr.20015
   Rider LG, 2013, MEDICINE, V92, P223, DOI 10.1097/MD.0b013e31829d08f9
   Rider LG, 2009, ARTHRITIS RHEUM-US, V60, P3425, DOI 10.1002/art.24904
   Riemekasten G, 1999, RHEUMATOLOGY, V38, P1153, DOI 10.1093/rheumatology/38.11.1153
   Robert N, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007893.pub2
   Rosenbohm A, 2015, J NEUROL, V262, P949, DOI 10.1007/s00415-014-7623-1
   Schwartz T, 2011, ANN RHEUM DIS, V70, P766, DOI 10.1136/ard.2010.137968
   Shah M, 2013, MEDICINE, V92, P25, DOI 10.1097/MD.0b013e31827f264d
   Shenavandeh Saeedeh, 2015, Med J Islam Repub Iran, V29, P233
   Silverberg JI, 2018, RHEUMATOLOGY, V57, P694, DOI 10.1093/rheumatology/kex465
   Singh S, 2006, RHEUMATOL INT, V26, P510, DOI 10.1007/s00296-005-0030-2
   Smith RL, 2004, J RHEUMATOL, V31, P1644
   Stringer E, 2010, J RHEUMATOL, V37, P1953, DOI 10.3899/jrheum.090953
   TARGOFF IN, 1990, ARTHRITIS RHEUM-US, V33, P1361, DOI 10.1002/art.1780330908
   Tateyama M, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2014-006763
   Timóteo AT, 2018, REV PORT CARDIOL, V37, P1001, DOI 10.1016/j.repc.2017.11.013
   Touma Z, 2008, JOINT BONE SPINE, V75, P334, DOI 10.1016/j.jbspin.2007.05.011
   Tschöpe C, 2006, CLIN RES CARDIOL, V95, P344, DOI 10.1007/s00392-006-0384-9
   Tsukiyama H, 2016, J DIABETES INVEST, V7, P587, DOI 10.1111/jdi.12454
   van Leuven SI, 2006, CARDIOVASC RES, V69, P341, DOI 10.1016/j.cardiores.2005.09.018
   Verma S, 2006, ARTHRIT RHEUM-ARTHR, V55, P564, DOI 10.1002/art.22108
   Vincze M, 2014, CLIN RHEUMATOL, V33, P1635, DOI 10.1007/s10067-014-2561-y
   Walsemann KM, 2016, SOC SCI MED, V152, P147, DOI 10.1016/j.socscimed.2016.01.038
   Weng MY, 2019, RHEUMATOLOGY, V58, P1935, DOI 10.1093/rheumatology/kez076
   Wu J, 2022, J DERMATOL TREAT, V33, P606, DOI 10.1080/09546634.2020.1773385
   Xie WH, 2019, ANN RHEUM DIS, V78, P1048, DOI 10.1136/annrheumdis-2018-214846
   Yilmaz M, 2013, METAB SYNDR RELAT D, V11, P132, DOI 10.1089/met.2012.0081
   Yonetsu T, 2013, CIRC-CARDIOVASC IMAG, V6, P665, DOI 10.1161/CIRCIMAGING.113.000345
   Zhang L, 2012, CLIN CARDIOL, V35, P686, DOI 10.1002/clc.22026
NR 97
TC 4
Z9 6
U1 0
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD JUN 24
PY 2022
VL 9
AR 827539
DI 10.3389/fmed.2022.827539
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 2S6SE
UT WOS:000821919500001
PM 35814777
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Llévenes, P
   Rodrigues-Díez, R
   Cros-Brunsó, L
   Prieto, MI
   Casaní, L
   Balfagón, G
   Blanco-Rivero, J
AF Llevenes, Pablo
   Rodrigues-Diez, Raquel
   Cros-Brunso, Laia
   Isabel Prieto, Ma
   Casani, Laura
   Balfagon, Gloria
   Blanco-Rivero, Javier
TI Beneficial Effect of a Multistrain Synbiotic Prodefen<SUP>®</SUP>
   Plus on the Systemic and Vascular Alterations Associated with
   Metabolic Syndrome in Rats: The Role of the Neuronal Nitric Oxide
   Synthase and Protein Kinase A
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; synbiotic; hypertension; superior mesenteric artery;
   perivascular nitrergic innervation; nitric oxide; neuronal nitric oxide
   synthase; protein kinase a
ID DIET-INDUCED OBESITY; GUT MICROBIOTA; MESENTERIC-ARTERY; OXIDATIVE
   STRESS; INSULIN SENSITIVITY; EXPRESSION; PROBIOTICS; ALTERS;
   INNERVATION; IMPROVEMENT
AB A high fat diet (HFD) intake is crucial for the development and progression of metabolic syndrome (MtS). Increasing evidence links gut dysbiosis with the metabolic and vascular alterations associated with MtS. Here we studied the use of a combination of various probiotic strains together with a prebiotic (synbiotic) in a commercially available Prodefen((R)) Plus. MtS was induced by HFD (45%) in male Wistar rats. Half of the MtS animals received Prodefen((R)) Plus for 4 weeks. At 12 weeks, we observed an increase in body weight, together with the presence of insulin resistance, liver steatosis, hypertriglyceridemia and hypertension in MtS rats. Prodefen((R)) Plus supplementation did not affect the body weight gain but ameliorated all the MtS-related symptoms. Moreover, the hypertension induced by HFD is caused by a diminished both nitric oxide (NO) functional role and release probably due to a diminished neuronal nitric oxide synthase (nNOS) activation by protein kinase A (PKA) pathway. Prodefen((R)) Plus supplementation for 4 weeks recovered the NO function and release and the systolic blood pressure was returned to normotensive values as a result. Overall, supplementation with Prodefen((R)) Plus could be considered an interesting non-pharmacological approach in MtS.
C1 [Llevenes, Pablo; Cros-Brunso, Laia; Balfagon, Gloria; Blanco-Rivero, Javier] Univ Autonoma Madrid, Sch Med, Dept Physiol, Calle Arzobispo Morcillo 4, Madrid 28029, Spain.
   [Rodrigues-Diez, Raquel] Univ Autonoma Madrid, Sch Med, Dept Pharmacol & Therapeut, Calle Arzobispo Morcillo 4, Madrid 28029, Spain.
   [Rodrigues-Diez, Raquel; Balfagon, Gloria; Blanco-Rivero, Javier] Ctr Biomed Res Network CIBER Cardiovasc Dis, Calle Melchor Fernandez Almagro 3, Madrid 28029, Spain.
   [Rodrigues-Diez, Raquel; Isabel Prieto, Ma; Balfagon, Gloria; Blanco-Rivero, Javier] Univ Hosp la Paz IdIPaz, Res Inst, Calle Pedro Rico 6, Madrid 28029, Spain.
   [Isabel Prieto, Ma] Hosp Univ la Paz, Dept Gen & Digest Surg, Paseo Castellana 261, Madrid 28046, Spain.
   [Casani, Laura] Res Inst Santa Creu, Carrer St Quinti 77-79, Barcelona 08041, Spain.
   [Casani, Laura] St Pau Hosp, Carrer St Quinti 77-79, Barcelona 08041, Spain.
C3 Autonomous University of Madrid; Autonomous University of Madrid;
   Hospital Universitario La Paz; Hospital of Santa Creu i Sant Pau
RP Blanco-Rivero, J (corresponding author), Univ Autonoma Madrid, Sch Med, Dept Physiol, Calle Arzobispo Morcillo 4, Madrid 28029, Spain.; Blanco-Rivero, J (corresponding author), Ctr Biomed Res Network CIBER Cardiovasc Dis, Calle Melchor Fernandez Almagro 3, Madrid 28029, Spain.; Blanco-Rivero, J (corresponding author), Univ Hosp la Paz IdIPaz, Res Inst, Calle Pedro Rico 6, Madrid 28029, Spain.
EM pablollevenes@gmail.com; raquel.rodrigues@uam.es; croslaia@gmail.com;
   iprieto@intermic.com; lcasani@santpau.cat; gloria.balfagon@uam.es;
   javier.blanco@uam.es
RI Rivero, Javier/ABE-8749-2020; Díez, Raquel/ABE-9703-2020; Prieto,
   Isabel/U-1061-2017; Casani, Laura/S-2115-2019; Blanco Rivero,
   Javier/J-6118-2014
OI PRIETO-NIETO, MARIA ISABEL/0000-0001-7619-0531; Cros-Brunso,
   Laia/0000-0002-7554-1018; Blanco Rivero, Javier/0000-0001-7232-2314;
   Casani, Laura/0000-0002-0139-4588; Rodrigues Diez,
   Raquel/0000-0002-6348-1505; Llevenes, Pablo/0000-0003-1925-7204
FU Italfarmaco, S.A [L.O.U. 83, 0138/2018]; CiberCV [CB16/11/00286];
   European Regional Development Grant (FEDER) (Comunidad de Madrid)
   [B2017/BMD-3676]; R + D projects for young researchers, Universidad
   Autonoma de Madrid (Comunidad de Madrid) [SI1-PJI-2019-00321]; Juan de
   la Cierva Program [IJCI-2017-31399]
FX This research was funded by Italfarmaco, S.A (L.O.U. 83; 0138/2018),
   CiberCV (Grant number: CB16/11/00286), the European Regional Development
   Grant (FEDER) (Comunidad de Madrid, Grant number B2017/BMD-3676), and R
   + D projects for young researchers, Universidad Autonoma de Madrid
   (Comunidad de Madrid (SI1-PJI-2019-00321). R.R.-D. received a fellowship
   from Juan de la Cierva Program (IJCI-2017-31399).
CR Alard J, 2016, ENVIRON MICROBIOL, V18, P1484, DOI 10.1111/1462-2920.13181
   Amor S, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010153
   [Anonymous], 2019, TURK J GASTROENTEROL
   Bagarolli RA, 2017, J NUTR BIOCHEM, V50, P16, DOI 10.1016/j.jnutbio.2017.08.006
   Barengolts E, 2016, ENDOCR PRACT, V22, P1224, DOI 10.4158/EP151157.RA
   Blanco-Rivero J, 2005, J VASC RES, V42, P526, DOI 10.1159/000088342
   Blanco-Rivero J, 2011, CLIN SCI, V121, P331, DOI 10.1042/CS20110072
   Blanco-Rivero J, 2011, BRIT J PHARMACOL, V162, P271, DOI 10.1111/j.1476-5381.2010.01030.x
   Bland JA., 2018, P 2018 ALASIM INT C, P81
   Caracuel L, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-43513-y
   Choi BR, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111797
   D'Souza A, 2010, PEDIATR RES, V67, P526, DOI 10.1203/PDR.0b013e3181d4ff2b
   de las Heras N, 2013, NUTR METAB CARDIOVAS, V23, P1107, DOI 10.1016/j.numecd.2012.11.009
   de las Heras N, 2009, J HYPERTENS, V27, pS37, DOI 10.1097/01.hjh.0000358836.64052.43
   de Queiroz DB, 2015, BRIT J PHARMACOL, V172, P4699, DOI 10.1111/bph.13244
   del Campo L, 2009, J HYPERTENS, V27, P791, DOI 10.1097/HJH.0b013e32832531e6
   Diplock AT, 1999, BRIT J NUTR, V81, pS1, DOI 10.1017/S0007114599000471
   Engin A, 2017, ADV EXP MED BIOL, V960, P111, DOI 10.1007/978-3-319-48382-5_5
   Everard A, 2013, BEST PRACT RES CL GA, V27, P73, DOI 10.1016/j.bpg.2013.03.007
   Ferrer M, 2004, EUR J PHARMACOL, V487, P167, DOI 10.1016/j.ejphar.2004.01.030
   Garcia-Menor Emilia, 2016, Glob Pediatr Health, V3, p2333794X16679587, DOI 10.1177/2333794X16679587
   GBDO AA, 2017, N Engl J Med, V377, P13, DOI [DOI 10.1056/NEJMOA1614362, 10.1056/NEJMoa1614362]
   Gómez-Guzmán M, 2015, MOL NUTR FOOD RES, V59, P2326, DOI 10.1002/mnfr.201500290
   Han NN, 2019, STEM CELL RES THER, V10, DOI 10.1186/s13287-019-1324-8
   Heuvelin E, 2010, J NUTR, V140, P7, DOI 10.3945/jn.109.114553
   Higarza SG, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0223019
   Hosomi R, 2019, J OLEO SCI, V68, P1133, DOI 10.5650/jos.ess19183
   Hwang JH, 2017, METAB BRAIN DIS, V32, P735, DOI 10.1007/s11011-017-9962-y
   Jumpertz R, 2011, AM J CLIN NUTR, V94, P58, DOI 10.3945/ajcn.110.010132
   Knopfholz J, 2014, CHOLESTEROL, DOI 10.1155/2014/261878
   Kumar R, 2020, PROBIOTICS ANTIMICRO, V12, P563, DOI 10.1007/s12602-019-09576-z
   Lamont BJ, 2016, NUTR DIABETES, V6, DOI 10.1038/nutd.2016.2
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Li HG, 2014, ATHEROSCLEROSIS, V237, P208, DOI 10.1016/j.atherosclerosis.2014.09.001
   Li Z, 2005, KIDNEY INT, V68, P2766, DOI 10.1111/j.1523-1755.2005.00747.x
   Llévenes P, 2018, VASC PHARMACOL, V108, P36, DOI 10.1016/j.vph.2018.05.001
   Marçal AC, 2013, CELL BIOCHEM FUNCT, V31, P65, DOI 10.1002/cbf.2861
   Marín J, 2000, CLIN SCI, V99, P277, DOI 10.1042/CS20000009
   Marques FZ, 2018, NAT REV CARDIOL, V15, P20, DOI 10.1038/nrcardio.2017.120
   Miller FJ, 1998, CIRC RES, V82, P1298, DOI 10.1161/01.RES.82.12.1298
   Mingrone G, 2002, INT J OBESITY, V26, P1165, DOI 10.1038/sj.ijo.0802053
   Nascimento AR, 2013, OBESITY, V21, P2046, DOI 10.1002/oby.20358
   NIELSEN KC, 1971, BRAIN RES, V27, P33, DOI 10.1016/0006-8993(71)90370-2
   Paveljsek D, 2018, BENEF MICROBES, V9, P515, DOI 10.3920/BM2017.0107
   Qin L, 2018, FOOD FUNCT, V9, P243, DOI [10.1039/c7fo01095h, 10.1039/C7FO01095H]
   Rashid SK, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0097458
   Raso GM, 2014, J NUTR BIOCHEM, V25, P81, DOI 10.1016/j.jnutbio.2013.09.006
   Rastelli M, 2018, OBESITY, V26, P792, DOI 10.1002/oby.22175
   Saiyasit N, 2020, NUTRITION, V69, DOI 10.1016/j.nut.2019.110576
   Sastre E, 2015, J HYPERTENS, V33, P1819, DOI 10.1097/HJH.0000000000000627
   Sastre E, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0126017
   Sastre E, 2010, REV NEUROLOGIA, V50, P727, DOI 10.33588/rn.5012.2010334
   Suo HY, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030155
   Surendran S, 2005, BIOCHEM BIOPH RES CO, V338, P919, DOI 10.1016/j.bbrc.2005.10.039
   Swinburn BA, 2019, LANCET, V393, P791, DOI 10.1016/S0140-6736(18)32822-8
   Tenorio-Jiménez C, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081761
   Timmerman HM, 2004, INT J FOOD MICROBIOL, V96, P219, DOI 10.1016/j.ijfoodmicro.2004.05.012
   Ting WJ, 2015, BRIT J NUTR, V114, P706, DOI 10.1017/S0007114515002469
   Toral M, 2014, CLIN SCI, V127, P33, DOI 10.1042/CS20130339
   Torres S, 2019, EUR J NUTR, V58, P27, DOI 10.1007/s00394-018-1790-2
   Vagena E, 2019, TRANSL PSYCHIAT, V9, DOI 10.1038/s41398-019-0470-1
   Vallianou N, 2019, CURR OBES REP, V8, P317, DOI 10.1007/s13679-019-00352-2
   Velazquez KT, 2019, WORLD J HEPATOL, V11, P619, DOI 10.4254/wjh.v11.i8.619
   Wanchai K, 2018, CLIN SCI, V132, P1545, DOI 10.1042/CS20180148
   Wang H, 1998, CIRC RES, V83, P832, DOI 10.1161/01.RES.83.8.832
   Wang JJ, 2015, ISME J, V9, P1, DOI 10.1038/ismej.2014.99
   Williams TD, 2003, CLIN EXP PHARMACOL P, V30, P769, DOI 10.1046/j.1440-1681.2003.t01-1-03808.x
   Xavier FE, 2011, EUR J PHARMACOL, V654, P280, DOI 10.1016/j.ejphar.2011.01.007
   Yang B, 2018, MOL IMMUNOL, V103, P71, DOI 10.1016/j.molimm.2018.09.001
   Yao FF, 2019, ARCH MED SCI, V15, P1336, DOI 10.5114/aoms.2019.86611
   Zhou YK, 2012, WORLD J GASTROENTERO, V18, P3977, DOI 10.3748/wjg.v18.i30.3977
NR 71
TC 12
Z9 14
U1 1
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2020
VL 12
IS 1
AR 117
DI 10.3390/nu12010117
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA KQ3KN
UT WOS:000516825500117
PM 31906276
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rocha, NG
   Templeton, DL
   Greiner, JJ
   Stauffer, BL
   DeSouza, CA
AF Rocha, Natalia G.
   Templeton, Danielle L.
   Greiner, Jared J.
   Stauffer, Brian L.
   DeSouza, Christopher A.
TI Metabolic syndrome and endothelin-1 mediated vasoconstrictor tone in
   overweight/obese adults
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Metabolic syndrome; Endothelin-1; Blood flow
ID CARDIOVASCULAR-DISEASE; DEPENDENT VASODILATION; OXIDATIVE STRESS;
   VASCULAR-TONE; HEART; DYSFUNCTION; DEFINITION; ANTAGONISM; RESISTANCE;
   RECEPTORS
AB Objective. To determine whether endothelin (ET)-1 vasoconstrictor tone is greater overweight and obese adults with the metabolic syndrome (MetS).
   Materials/Methods. Forty overweight/obese middle-aged and older adults (age: 43-71 years; BMI: 25.1-36.9 kg/m(2)) were studied: 20 without MetS (13 M/7 F) and 20 with MetS (13 M/7 F). MetS was established according to NCEP ATP III guidelines. Forearm blood flow (FBF; plethysmography) responses to intra-arterial infusion of selective ETA receptor blockade (BQ-123; 100 nmol/min; for 60 min) and non-selective ETA/B receptor blockade (BQ-123 + BQ-788 [50 nmol/min for 60 min]) were determined.
   Results. In response to the selective ETA antagonism, there was a significant increase in forearm blood flow from baseline in both groups. However, the increase in forearm blood flow was significantly higher (P = 0.03; similar to 45%) in the overweight/obese group with MetS than the group without MetS. In contrast, there were no significant group differences in FBF responses to nonselective ETA/B receptor blockade. Peak vasodilator responses to nonselective ETA/B blockade were similar to 0% higher than baseline blood flow in the overweight/obese groups without and with MetS.
   Conclusion. MetS is associated with higher ET-1 vasoconstrictor tone in overweight/obese adults. The enhanced ET-1 vasoconstrictor activity with MetS is mediated by the ETA receptor subtype. (c) 2014 Elsevier Inc. All rights reserved.
C1 [Rocha, Natalia G.; Templeton, Danielle L.; Greiner, Jared J.; Stauffer, Brian L.; DeSouza, Christopher A.] Univ Colorado, Dept Integrat Physiol, Integrat Vasc Biol Lab, Boulder, CO 80309 USA.
   [Stauffer, Brian L.; DeSouza, Christopher A.] Univ Colorado, Dept Med, Aurora, CO 80045 USA.
   [Stauffer, Brian L.; DeSouza, Christopher A.] Hlth Sci Ctr, Aurora, CO 80045 USA.
   [Stauffer, Brian L.] Denver Hlth Med Ctr, Denver, CO 80204 USA.
   [Rocha, Natalia G.] Univ Fed Fluminense, Dept Physiol & Pharmacol, BR-24210130 Niteroi, RJ, Brazil.
C3 University of Colorado System; University of Colorado Boulder;
   University of Colorado System; University of Colorado Anschutz Medical
   Campus; Denver Health Medical Center; Universidade Federal Fluminense
RP DeSouza, CA (corresponding author), Univ Colorado, Dept Integrat Physiol, Integrat Vasc Biol Lab, 354 UCB, Boulder, CO 80309 USA.
EM desouzac@colorado.edu
RI Stauffer, Brian/W-8251-2019; Rocha, Natalia Galito/AAN-7903-2020
OI Stauffer, Brian/0000-0003-3418-7750; Rocha, Natalia
   Galito/0000-0002-1990-9834
FU National Institutes of Health [HL077450, HL076434, UL1 TR000154];
   American Heart Association award [0840167N]; American Heart Association
   (AHA) [0840167N] Funding Source: American Heart Association (AHA)
FX This study was supported by National Institutes of Health awards
   HL077450, HL076434, and UL1 TR000154 and American Heart Association
   award 0840167N.
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Cardillo C, 1999, HYPERTENSION, V33, P753, DOI 10.1161/01.HYP.33.2.753
   Dashwood MR, 2002, ATHEROSCLEROSIS, V160, P297, DOI 10.1016/S0021-9150(01)00586-X
   Diehl KJ, 2013, ATHEROSCLEROSIS, V229, P130, DOI 10.1016/j.atherosclerosis.2013.04.006
   Elgebaly MM, 2007, VASC PHARMACOL, V47, P125, DOI 10.1016/j.vph.2007.05.006
   Gavin JR, 1997, DIABETES CARE, V20, P1183
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Grundy SM, 2004, ARTERIOSCL THROM VAS, V24, pE13, DOI 10.1161/01.ATV.0000111245.75752.C6
   HAYNES WG, 1995, J CARDIOVASC PHARM, V26, pS40
   Hunt KJ, 2004, CIRCULATION, V110, P1251, DOI 10.1161/01.CIR.0000140762.04598.F9
   Ihling C, 2001, CIRCULATION, V104, P864, DOI 10.1161/hc3301.094742
   Ingelsson E, 2007, CIRCULATION, V116, P375, DOI 10.1161/CIRCULATIONAHA.107.688788
   Kelly JJ, 1999, CLIN EXP PHARMACOL P, V26, P158, DOI 10.1046/j.1440-1681.1999.03011.x
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lohman T., 1988, Athropometric Standardization Reference Manual
   Lorenzo C, 2003, DIABETES CARE, V26, P3153, DOI 10.2337/diacare.26.11.3153
   Lüscher TF, 2000, CIRCULATION, V102, P2434, DOI 10.1161/01.CIR.102.19.2434
   MASAKI T, 1991, CIRCULATION, V84, P1457, DOI 10.1161/01.CIR.84.4.1457
   Mather KJ, 2002, DIABETES, V51, P3517, DOI 10.2337/diabetes.51.12.3517
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Miyauchi T, 1999, ANNU REV PHYSIOL, V61, P391, DOI 10.1146/annurev.physiol.61.1.391
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Onat A, 2011, EXPERT OPIN PHARMACO, V12, P1887, DOI 10.1517/14656566.2011.585462
   Patel JN, 2002, CLIN SCI, V103, P409, DOI 10.1042/cs1030409
   Pierre LN, 1998, J CARDIOVASC PHARM, V31, pS74, DOI 10.1097/00005344-199800001-00024
   Pierre LN, 1998, BRIT J PHARMACOL, V124, P499, DOI 10.1038/sj.bjp.0701865
   Pollock David M., 2005, Current Vascular Pharmacology, V3, P365, DOI 10.2174/157016105774329408
   Sharma S, 2004, ETHNIC DIS, V14, P43
   Stauffer BL, 2010, AM J PHYSIOL-REG I, V298, pR261, DOI 10.1152/ajpregu.00626.2009
   Steinberg HO, 1996, J CLIN INVEST, V97, P2601, DOI 10.1172/JCI118709
   Touyz RM, 2003, CAN J PHYSIOL PHARM, V81, P533, DOI 10.1139/Y03-009
   Van Guilder GP, 2008, AM J PHYSIOL-HEART C, V294, pH1685, DOI 10.1152/ajpheart.01281.2007
   Van Guilder GP, 2006, OBESITY, V14, P2127, DOI 10.1038/oby.2006.248
   Van Guilder GP, 2007, HYPERTENSION, V50, P403, DOI 10.1161/HYPERTENSIONAHA.107.088294
   Van Guilder GP, 2006, J CARDIOVASC PHARM, V47, P310, DOI 10.1097/01.fjc.0000205097.29946.d3
   Van Guilder GP, 2005, AM J PHYSIOL-ENDOC M, V289, pE807, DOI 10.1152/ajpendo.00072.2005
   Verma S, 2002, CIRCULATION, V105, P1890, DOI 10.1161/01.CIR.0000015126.83143.B4
   Wei BR, 2011, AM J HYPERTENS, V24, P976, DOI 10.1038/ajh.2011.88
   Weil BR, 2011, AM J PHYSIOL-HEART C, V301, pH689, DOI 10.1152/ajpheart.00206.2011
NR 39
TC 17
Z9 18
U1 0
U2 5
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUL
PY 2014
VL 63
IS 7
BP 951
EP 956
DI 10.1016/j.metabol.2014.04.007
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AJ5ID
UT WOS:000337715000010
PM 24856242
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Martín-Cordero, L
   García, JJ
   Ortega, E
AF Martin-Cordero, Leticia
   Garcia, Juan J.
   Ortega, Eduardo
TI Noradrenaline-mediated Inhibition of Inflammatory Cytokines is Altered
   in Macrophages from Obese Zucker Rats: Effect of Habitual Exercise
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Article
DE Inflammation; macrophages; metabolic syndrome; noradrenaline; obesity;
   physical activity
ID NECROSIS-FACTOR-ALPHA; METABOLIC SYNDROME; IN-VIVO; STRESS; RELEASE;
   MODULATION; EXPRESSION; IL-6
AB The obese Zucker rat (fa/fa) (ObZ) is a good animal model for Metabolic Syndrome (MS)-associated neuroendocrine and inflammatory disorders. The aim of the present investigation was to evaluate the effect of noradrenaline (NA) on the release of IL-1 beta, IL-6 and TNF alpha by macrophages from ObZ, as well as the effect of habitual exercise (running, 5days/week for 35 min at 35cm/s for 14week); all of them using lean Zucker rats (Fa/fa) (LZ) as reference values. Cytokines were determined by ELISA in the supernatants of macrophages cultured for 24h (37 degrees C, 5% CO2 and 100% RH) in presence or absence of 10-5M NA. Both the spontaneous and NA-induced release of IL-1 beta and IL-6 were higher in sedentary obese (ObSZ) rats than in healthy LZ rats (a significant lower spontaneous production of TNF alpha was also found in the ObSZ rats). While the NA-induced release of IL-1 beta was higher in the exercised obese (ObTZ) rats, the NA-induced production of IL-6 was lower compared with ObSZ rats. In addition, NA has an inhibitory role on the release of IL-1 beta and TNF alpha (with respect to the spontaneous release) in both lean and obese (sedentary and exercised) rats. However, NA inhibits the IL-6 production by macrophages from lean and exercised obese animals, but promotes IL-6 release in the sedentary obese rats.
C1 [Martin-Cordero, Leticia; Garcia, Juan J.; Ortega, Eduardo] Univ Extremadura, Fac Sci, Dept Physiol, Immunophysiol Res Grp, Badajoz, Spain.
C3 Universidad de Extremadura
RP Ortega, E (corresponding author), Univ Extremadura, Fac Sci, Dept Physiol, Immunophysiol Res Grp, Badajoz, Spain.
EM orincon@unex.es
RI Martin-Cordero, Leticia/H-9711-2015; Ortega, Eduardo/H-9891-2016;
   Garcia, Juan/C-7383-2013
OI Martin-Cordero, Leticia/0000-0002-3651-2265; Ortega,
   Eduardo/0000-0002-7007-7615; Garcia, Juan/0000-0002-8222-4213
FU Ministerio de Ciencia e Innovacion-Fondo Europeo de Desarrollo Regional
   [DEP2006 56187]; Junta de Extremadura-FEDER, Spain [GR10020]
FX This work was supported by Ministerio de Ciencia e Innovacion-Fondo
   Europeo de Desarrollo Regional (DEP2006 56187) and Junta de
   Extremadura-FEDER (GR10020), Spain.
CR Bassuk SS, 2005, J APPL PHYSIOL, V99, P1193, DOI 10.1152/japplphysiol.00160.2005
   Bastard JP, 2002, J CLIN ENDOCR METAB, V87, P2084, DOI 10.1210/jc.87.5.2084
   Besedovsky HO, 2007, BRAIN BEHAV IMMUN, V21, P34, DOI 10.1016/j.bbi.2006.09.008
   Calder PC, 2011, BRIT J NUTR, V106, pS1, DOI 10.1017/S0007114511005460
   Das UN, 2002, EXP BIOL MED, V227, P989, DOI 10.1177/153537020222701106
   de Lemos ET, 2009, NUTRITION, V25, P330, DOI 10.1016/j.nut.2008.08.014
   de Lemos ET, 2007, MED SCI MONITOR, V13, pBR172
   de Lemos ET, 2012, OXID MED CELL LONGEV, V2012, DOI 10.1155/2012/741545
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Eder K, 2009, INFLAMM RES, V58, P727, DOI 10.1007/s00011-009-0060-4
   Elenkov IJ, 2005, NEUROIMMUNOMODULAT, V12, P255, DOI 10.1159/000087104
   Elenkov IJ, 2002, ANN NY ACAD SCI, V966, P290, DOI 10.1111/j.1749-6632.2002.tb04229.x
   Fain JN, 2004, INT J OBESITY, V28, P616, DOI 10.1038/sj.ijo.0802594
   Fernandez-Veledo Sonia, 2009, Archives of Physiology and Biochemistry, V115, P227, DOI 10.1080/13813450903164330
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   HOTAMISLIGIL GS, 1995, J CLIN INVEST, V95, P2409, DOI 10.1172/JCI117936
   Martín-Cordero L, 2013, J PHYSIOL BIOCHEM, V69, P125, DOI 10.1007/s13105-012-0196-5
   Martin-Cordero L, 2009, EUR J APPL PHYSIOL, V107, P535, DOI 10.1007/s00421-009-1140-4
   Martín-Cordero L, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-42
   Martín-Cordero L, 2011, NEUROIMMUNOMODULAT, V18, P123, DOI 10.1159/000322053
   Mathur N, 2008, MEDIAT INFLAMM, V2008, DOI 10.1155/2008/109502
   Meltzer JC, 2004, BRAIN BEHAV IMMUN, V18, P262, DOI 10.1016/j.bbi.2003.09.003
   Nance DM, 2007, BRAIN BEHAV IMMUN, V21, P736, DOI 10.1016/j.bbi.2007.03.008
   Ortega E, 2003, EXERC IMMUNOL REV, V9, P70
   Ortega E, 2000, MECH AGEING DEV, V118, P103, DOI 10.1016/S0047-6374(00)00160-3
   Ortega E, 2007, NEUROIMMUNOMODULAT, V14, P206, DOI 10.1159/000110648
   Ortega E, 2010, HEAT SHOCK PROTEINS, V5, P327, DOI 10.1007/978-90-481-3381-9_19
   Pedersen BK, 2006, ESSAYS BIOCHEM, V42, P105, DOI 10.1042/bse0420105
   Petersen AMW, 2005, J APPL PHYSIOL, V98, P1154, DOI 10.1152/japplphysiol.00164.2004
   Recasens M, 2004, Rev Med Univ Navarra, V48, P49
   Straznicky NE, 2010, CURR OPIN LIPIDOL, V21, P21, DOI 10.1097/MOL.0b013e3283329c62
   Straznicky NE, 2010, DIABETES, V59, P71, DOI 10.2337/db09-0934
   Wärnberg J, 2008, CURR OPIN LIPIDOL, V19, P11, DOI 10.1097/MOL.0b013e3282f4096b
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
NR 35
TC 12
Z9 12
U1 0
U2 3
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PD SEP
PY 2013
VL 13
IS 3
BP 234
EP 239
PG 6
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA 242HD
UT WOS:000326228600002
PM 23808809
DA 2025-06-11
ER

PT J
AU Boersma, GJ
   Benthem, L
   van Dijk, G
   Scheurink, AJW
AF Boersma, Gretha J.
   Benthem, Lambertus
   van Dijk, Gertjan
   Scheurink, Anton J. W.
TI Individual variation in the (patho)physiology of energy balance
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Coping style; Insulin; Hypertension; Physical activity
ID LOW-AVOIDANCE RATS; ROMAN HIGH-AVOIDANCE; CORTICOTROPIN-RELEASING
   FACTOR; PLASMA-CATECHOLAMINE; CORTICOSTERONE LEVELS;
   CEREBROSPINAL-FLUID; INSULIN-RESISTANCE; METABOLIC SYNDROME; COPING
   STRATEGIES; STRESS RESPONSES
AB There are large individual differences in the susceptibility for metabolic disorders such as obesity, the metabolic syndrome and type 2 diabetes. Unfortunately, most animal studies in this field ignore the importance of individual variation which limits the face validity of these studies for translation to the human situation. We have performed a series of studies that were particularly focused on the individual differences in the (patho)physiology of energy balance. The studies were performed with passive and proactive individuals of two different rat strains: the Roman High and Low Avoidance rats and the Wild type Groningen rat. The data reveal that passive and proactive individuals differ significantly on several parameters, i.e. body composition, Hypothalamic-Pituitary-Adrenal (HPA) axis activity, plasma levels of insulin and leptin, intestinal transit time, systolic blood pressure and meal patterns. We also found that the selection line of the Roman Low Avoidance rat may be considered as a non-obese animal model for the metabolic syndrome, since these rats display, under sedentary conditions, many of the related symptoms such as hypertension, visceral adiposity and insulin resistance during an intravenous glucose tolerance test. These symptoms disappeared when the animals were allowed to exercise voluntarily in a running wheel. We conclude that experiments with passive and proactive individuals are highly relevant for studying the (patho)physiology and behavior of energy balance and the related metabolic disorders. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Boersma, Gretha J.; van Dijk, Gertjan; Scheurink, Anton J. W.] Univ Groningen, Dept Neuroendocrinol, NL-9750 AA Haren, Netherlands.
   [Benthem, Lambertus] AstraZeneca R&D, Biosci Diabet Obes, Molndal, Sweden.
C3 University of Groningen; AstraZeneca
RP Boersma, GJ (corresponding author), Univ Groningen, Dept Neuroendocrinol, POB 14, NL-9750 AA Haren, Netherlands.
EM g.j.boersma@rug.nl
OI van Dijk, Gertjan/0000-0002-6565-4019
FU AstraZeneca
FX These studies were supported by an unrestricted research grant by
   AstraZeneca.
CR Angerer P, 2000, J AM COLL CARDIOL, V36, P1781, DOI 10.1016/S0735-1097(00)00944-X
   Asensio C, 2004, INT J OBESITY, V28, pS45, DOI 10.1038/sj.ijo.0802856
   AUBRY JM, 1995, NEUROENDOCRINOLOGY, V61, P89, DOI 10.1159/000126829
   BENUS RF, 1991, EXPERIENTIA, V47, P1008, DOI 10.1007/BF01923336
   Bi S, 2005, ENDOCRINOLOGY, V146, P1676, DOI 10.1210/en.2004-1441
   BIGNAMI G, 1965, ANIM BEHAV, V13, P221, DOI 10.1016/0003-3472(65)90038-2
   Boersma GJ, 2009, PHYSIOL BEHAV, V97, P353, DOI 10.1016/j.physbeh.2009.03.005
   BOERSMA GJ, APPETITE, V3, P820
   Boersma GJ, 2010, PHYSIOL BEHAV, V100, P401, DOI 10.1016/j.physbeh.2010.04.007
   Bohus B, 1987, PROG BRAIN RES <D>, V72, P57
   Booth AO, 2006, PUBLIC HEALTH NUTR, V9, P1055, DOI 10.1017/PHN2006980
   BORTNER RW, 1967, J CHRON DIS, V20, P525, DOI 10.1016/0021-9681(67)90083-5
   Boyle SH, 2004, PSYCHOSOM MED, V66, P629, DOI 10.1097/01.psy.0000138122.93942.4a
   BROADHURST PL, 1975, BEHAV GENET, V5, P299, DOI 10.1007/BF01073201
   BROWN MS, 1966, P SOC EXP BIOL MED, V121, P989
   Buwalda B, 1997, PSYCHONEUROENDOCRINO, V22, P297, DOI 10.1016/S0306-4530(97)00032-2
   Carroll JF, 2009, OBES SURG, V19, P47, DOI 10.1007/s11695-008-9642-4
   Chavez M, 1996, AM J PHYSIOL-REG I, V271, pR727, DOI 10.1152/ajpregu.1996.271.3.R727
   Chitwood LF, 1997, PERCEPT MOTOR SKILL, V84, P507, DOI 10.2466/pms.1997.84.2.507
   COWLEY AW, 1983, FED PROC, V42, P3170
   De Boer SF, 2003, EUR J PHARMACOL, V463, P145, DOI 10.1016/S0014-2999(03)01278-0
   DEBOER SF, 1990, PHYSIOL BEHAV, V47, P1089, DOI 10.1016/0031-9384(90)90357-A
   Dennis KE, 1996, ADDICT BEHAV, V21, P103, DOI 10.1016/0306-4603(95)00042-9
   DRAZEN DL, DIABETES, V52, P2928
   Engel G L, 1972, Ciba Found Symp, V8, P57
   Escorihuela RM, 1999, PHYSIOL BEHAV, V67, P19, DOI 10.1016/S0031-9384(99)00064-5
   FERRE P, 1995, PHYSIOL BEHAV, V58, P1209, DOI 10.1016/0031-9384(95)02068-3
   GENTSCH C, 1982, PHYSIOL BEHAV, V28, P259, DOI 10.1016/0031-9384(82)90072-5
   Giorgi O, 2007, NEUROSCI BIOBEHAV R, V31, P148, DOI 10.1016/j.neubiorev.2006.07.008
   GOLDBERG LR, 1993, AM PSYCHOL, V48, P26, DOI 10.1037/0003-066X.48.1.26
   Haskell-Luevano C, 2009, FASEB J, V23, P642, DOI 10.1096/fj.08-109686
   Hautala AJ, 2003, AM J PHYSIOL-HEART C, V285, pH1747, DOI 10.1152/ajpheart.00202.2003
   Henry J.P., 1997, STRESS HLTH SOCIAL E
   HESSING MJC, 1994, PHYSIOL BEHAV, V55, P39, DOI 10.1016/0031-9384(94)90007-8
   JENKINS CD, 1971, PSYCHOSOM MED, V33, P193, DOI 10.1097/00006842-197105000-00001
   Kolotkin RL, 1997, OBES RES, V5, P434, DOI 10.1002/j.1550-8528.1997.tb00667.x
   Koolhaas JM, 2010, FRONT NEUROENDOCRIN, V31, P307, DOI 10.1016/j.yfrne.2010.04.001
   Koolhaas JM, 1999, NEUROSCI BIOBEHAV R, V23, P925, DOI 10.1016/S0149-7634(99)00026-3
   Korte SM, 1997, PHYSIOL BEHAV, V62, P437, DOI 10.1016/S0031-9384(97)00149-2
   LANDGRAF R, STRESS, V6, P73, DOI DOI 10.1080/1025389031000104201
   Meerlo P, 1997, PSYCHONEUROENDOCRINO, V22, P155, DOI 10.1016/S0306-4530(96)00047-9
   Moreno M, 2010, NEUROPSYCHOPHARMACOL, V35, P1198, DOI 10.1038/npp.2009.224
   Narita K, 2008, PSYCHONEUROENDOCRINO, V33, P305, DOI 10.1016/j.psyneuen.2007.11.013
   Niaura R, 2000, PSYCHOSOM MED, V62, P7, DOI 10.1097/00006842-200001000-00002
   Nicholson Ian A M, 1998, Hist Psychol, V1, P52, DOI 10.1037/1093-4510.1.1.52
   Olson MB, 2005, PSYCHOSOM MED, V67, P546, DOI 10.1097/01.psy.0000170830.99263.4e
   PINEL JPJ, J COMP PHYSL PSYCHOL, V92, P708
   PITTMAN QJ, 1982, ENDOCRINOLOGY, V110, P1058, DOI 10.1210/endo-110-3-1058
   POTEGAL M, 1989, BEHAV NEURAL BIOL, V51, P247, DOI 10.1016/S0163-1047(89)90887-X
   Qi D, 2007, AM J PHYSIOL-ENDOC M, V292, pE654, DOI 10.1152/ajpendo.00453.2006
   RAIKKONEN K, 1994, J BEHAV MED, V17, P605, DOI 10.1007/BF01857600
   Ramos A, 1997, BEHAV BRAIN RES, V85, P57, DOI 10.1016/S0166-4328(96)00164-7
   Ravaja N, 1996, J CLIN EPIDEMIOL, V49, P335, DOI 10.1016/0895-4356(95)00524-2
   RICHARDSON RD, 1994, AM J PHYSIOL, V266, pR59, DOI 10.1152/ajpregu.1994.266.1.R59
   RIVEST R, 1988, EXPERIENTIA, V42, pA32
   Rossi R, 1997, BEHAV GENET, V27, P565, DOI 10.1023/A:1021461116391
   SCHWARTZ MW, 1992, ENDOCRINOLOGY, V130, P3608, DOI 10.1210/en.130.6.3608
   Seeley RJ, 1996, HORM METAB RES, V28, P664, DOI 10.1055/s-2007-979874
   SEIDEL A, 1990, J NEURAL TRANSM-GEN, V81, P73, DOI 10.1007/BF01245447
   Seigers R, 2008, BEHAV BRAIN RES, V186, P168, DOI 10.1016/j.bbr.2007.08.004
   Sgoifo A, 1996, PHYSIOL BEHAV, V60, P1403, DOI 10.1016/S0031-9384(96)00229-6
   SHEPHERD R, FORUM NUTR, V57, P36
   Smith TW, 2006, ANNU REV CLIN PSYCHO, V2, P435, DOI 10.1146/annurev.clinpsy.2.022305.095257
   Sovio U, 2007, J HEALTH PSYCHOL, V12, P371, DOI 10.1177/1359105307074301
   Spoolder HAM, 1996, APPL ANIM BEHAV SCI, V49, P185, DOI 10.1016/0168-1591(96)01033-7
   STEFFENS AB, 1988, AM J PHYSIOL, V255, pR200, DOI 10.1152/ajpregu.1988.255.2.R200
   Steimer T, 2005, NEUROSCI BIOBEHAV R, V29, P99, DOI 10.1016/j.neubiorev.2004.07.002
   Steimer T, 1997, BEHAV GENET, V27, P503, DOI 10.1023/A:1021448713665
   Steimer T, 1999, J BIOL RHYTHM, V14, P221, DOI 10.1177/074873099129000632
   Steimer T, 1998, INT J DEV NEUROSCI, V16, P165, DOI 10.1016/S0736-5748(98)00032-X
   STRUBBE JH, 1988, PHYSIOL BEHAV, V44, P205, DOI 10.1016/0031-9384(88)90139-4
   Tamashiro KLK, 2009, DIABETES, V58, P1116, DOI 10.2337/db08-1129
   Teixeira P J., INT J BEHAV NUTR PHY, V1, P12
   Van Dijk G, 1999, AM J PHYSIOL-REG I, V276, pR1425, DOI 10.1152/ajpregu.1999.276.5.R1425
   van Dijk G, 2008, EUR J PHARMACOL, V585, P137, DOI 10.1016/j.ejphar.2007.11.079
   vanDijk G, 1996, AM J PHYSIOL-REG I, V271, pR1096, DOI 10.1152/ajpregu.1996.271.4.R1096
   VANOORTMERSSEN GA, 1981, BEHAV GENET, V11, P115, DOI 10.1007/BF01065622
   Veenema AH, 2005, PSYCHOPHARMACOLOGY, V178, P151, DOI 10.1007/s00213-004-2005-5
   VERBEEK MEM, 1995, ANIM BEHAV, V48, P1121
   WECHSLER B, 1995, APPL ANIM BEHAV SCI, V43, P123, DOI 10.1016/0168-1591(95)00557-9
   WILLIAMS AR, 1985, PEPTIDES, V6, P69, DOI 10.1016/0196-9781(85)90013-0
   Wolf M, 2008, P NATL ACAD SCI USA, V105, P15825, DOI 10.1073/pnas.0805473105
   WOODS SC, 1994, PSYCHON B REV, V1, P141, DOI 10.3758/BF03200770
   Zhang JP, 2006, PSYCHOSOM MED, V68, P718, DOI 10.1097/01.psy.0000228343.89466.11
NR 84
TC 14
Z9 14
U1 0
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD APR 18
PY 2011
VL 103
IS 1
SI SI
BP 89
EP 97
DI 10.1016/j.physbeh.2010.12.026
PG 9
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA 749VR
UT WOS:000289499800015
PM 21237186
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Liu, L
   Li, X
   Wu, MY
   Yu, M
   Wang, LM
   Hu, LQ
   Li, YP
   Song, LL
   Wang, YJ
   Mei, SR
AF Liu, Ling
   Li, Xiang
   Wu, Mingyang
   Yu, Meng
   Wang, Limei
   Hu, Liqin
   Li, Yaping
   Song, Lulu
   Wang, Youjie
   Mei, Surong
TI Individual and joint effects of metal exposure on metabolic syndrome
   among Chinese adults
SO CHEMOSPHERE
LA English
DT Article
DE Metals; Metabolic syndrome; Joint effects; Elastic net model; Chinese
   adults
ID OXIDATIVE STRESS; VARIABLE SELECTION; PHYSICAL-ACTIVITY;
   NATIONAL-HEALTH; SELENIUM LEVELS; TRACE-ELEMENTS; SERUM ZINC; US ADULTS;
   ASSOCIATION; RISK
AB Growing evidence suggests that metal exposure contributes to metabolic syndrome (MetS), but little is known about the effects of combined exposure to metal mixtures. This cross-sectional study included 3748 adults who were recruited from the Medical Physical Examination Center of Tongji Hospital, Wuhan, China. The levels of 21 metal(loid)s in urine were measured by inductively coupled plasma mass spectrometry. MetS was diagnosed according to National Cholesterol Education Program's Adult Treatment Panel III recommendations. Multivariate logistic regression model was uesd to explore the effects of single-metal and multi-metal exposures. The elastic net (ENET) regularization with an environmental risk score (ERS) was performed to estimate the joint effects of exposure to metal mixtures. A total of 636 participants (17%) were diagnosed with MetS. In single metal models, MetS was positively associated with zinc (Zn) and negatively associated with nickel (Ni). In multiple metal models, the associations remained significant after adjusting for the other metals. In the joint association analysis, the ENET models selected Zn as the strongest predictor of MetS. Compared to the lowest quartile, the highest quartile of ERS was associated with an elevated risk of MetS (OR = 3.72; 95% CI: 2.77, 5.91;P-trend < 0.001). Overall, we identified that the combined effect of multiple metals was related to an increased MetS risk, with Zn being the major contributor. These findings need further validation in prospective studies.
C1 [Liu, Ling; Li, Xiang; Yu, Meng; Wang, Limei; Hu, Liqin; Li, Yaping; Wang, Youjie; Mei, Surong] Huazhong Univ Sci & Technol, State Key Lab Environm Hlth Incubat,Tongji Med Co, Key Lab Environm & Hlth Wuhan,Minist Environm Pro, Key Lab Environm & Hlth,Minist Educ,Sch Publ Hlth, 13 Hongkong Rd, Wuhan 430030, Hubei, Peoples R China.
   [Wu, Mingyang; Song, Lulu; Wang, Youjie] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Maternal & Child Hlth, Wuhan, Hubei, Peoples R China.
C3 Ministry of Education - China; Huazhong University of Science &
   Technology; Huazhong University of Science & Technology
RP Wang, YJ (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Maternal & Child Hlth, Wuhan, Hubei, Peoples R China.; Mei, SR (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China.
EM wangyoujie@mails.tjmu.edu.cn; surongmei@hust.edu.cn
RI Li, Xiang/IYT-7014-2023; Li, zhuangzhuang/JAD-1371-2023; Wu,
   Mingyang/JRX-1464-2023; Song, Lulu/X-4115-2019
OI Song, Lulu/0000-0002-9105-2580; Wu, mingyang/0000-0003-3001-1897
FU National Key Research and Development Program of China [2019YFC1605100]
FX We appreciate the hospital and all participants in this study. This work
   was supported by the National Key Research and Development Program of
   China (2019YFC1605100) .
CR Agier L, 2016, ENVIRON HEALTH PERSP, V124, P1848, DOI 10.1289/EHP172
   Ahn BI, 2014, BIOL TRACE ELEM RES, V160, P169, DOI 10.1007/s12011-014-0045-1
   Aigner E, 2015, WORLD J HEPATOL, V7, P177, DOI 10.4254/wjh.v7.i2.177
   Ainsworth BE, 2011, MED SCI SPORT EXER, V43, P1575, DOI 10.1249/MSS.0b013e31821ece12
   Al osman M, 2019, BIOMETALS, V32, P563, DOI 10.1007/s10534-019-00193-5
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Aminov Z, 2020, ENVIRON POLLUT, V260, DOI 10.1016/j.envpol.2020.114004
   [Anonymous], 2019, ENV EPIDEMIOL, V3, P384
   Ashrap P, 2020, ENVIRON INT, V138, DOI 10.1016/j.envint.2020.105606
   Barros RPA, 2011, CELL METAB, V14, P289, DOI 10.1016/j.cmet.2011.08.005
   Bauer JA, 2020, ENVIRON HEALTH PERSP, V128, DOI 10.1289/EHP6803
   BENJAMINI Y, 1995, J R STAT SOC B, V57, P289, DOI 10.1111/j.2517-6161.1995.tb02031.x
   Buha A, 2020, TOXICS, V8, DOI 10.3390/toxics8030063
   Bulka CM, 2019, ENVIRON RES, V168, P397, DOI 10.1016/j.envres.2018.10.022
   Cedergreen N, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0096580
   Centers for Disease Control and Prevention, 2019, 4 NAT REP HUM EXP EN
   Christensen KLY, 2013, INT J HYG ENVIR HEAL, V216, P624, DOI 10.1016/j.ijheh.2012.08.005
   Chung JY, 2015, J ENDOCRINOL INVEST, V38, P65, DOI 10.1007/s40618-014-0132-3
   Czernichow S, 2009, AM J CLIN NUTR, V90, P329, DOI 10.3945/ajcn.2009.27635
   De Long NE, 2017, DIABET METAB SYND OB, V10, P101, DOI 10.2147/DMSO.S95296
   Deshmukh-Taskar PR, 2009, PUBLIC HEALTH NUTR, V12, P2493, DOI 10.1017/S1368980009991261
   Dineley KE, 2003, J NEUROCHEM, V85, P563, DOI 10.1046/j.1471-4159.2003.01678.x
   Drakvik E, 2020, ENVIRON INT, V134, DOI 10.1016/j.envint.2019.105267
   Driessnack MK, 2017, ECOTOX ENVIRON SAFE, V140, P65, DOI 10.1016/j.ecoenv.2017.02.023
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Esteban M, 2009, ENVIRON INT, V35, P438, DOI 10.1016/j.envint.2008.09.003
   Fang CC, 2019, J TRACE ELEM MED BIO, V52, P209, DOI 10.1016/j.jtemb.2018.12.017
   Feng W, 2015, ENVIRON HEALTH PERSP, V123, P217, DOI 10.1289/ehp.1307563
   Firmann M, 2008, BMC CARDIOVASC DISOR, V8, DOI 10.1186/1471-2261-8-6
   Frazzini V, 2006, BIOGERONTOLOGY, V7, P307, DOI 10.1007/s10522-006-9045-7
   Friedman J, 2010, J STAT SOFTW, V33, P1, DOI 10.18637/jss.v033.i01
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gambelunghe A, 2016, ENVIRON RES, V149, P157, DOI 10.1016/j.envres.2016.05.015
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Gu DF, 2005, LANCET, V365, P1398, DOI 10.1016/S0140-6736(05)66375-1
   Haines DA, 2017, INT J HYG ENVIR HEAL, V220, P13, DOI 10.1016/j.ijheh.2016.08.002
   Harbison R.D., 2015, Hamilton Hardy's Industrial Toxicology, V6th
   He D, 2014, ENDOCRINE, V46, P231, DOI 10.1007/s12020-013-0110-0
   Heitland P, 2006, CLIN CHIM ACTA, V365, P310, DOI 10.1016/j.cca.2005.09.013
   Hordyjewska A, 2014, BIOMETALS, V27, P611, DOI 10.1007/s10534-014-9736-5
   Hou YY, 2013, ENVIRON HEALTH PERSP, V121, P237, DOI 10.1289/ehp.1205731
   Howe CG, 2020, ENVIRON HEALTH PERSP, V128, DOI 10.1289/EHP7201
   Huang XH, 2017, NUTRIENTS, V9, DOI 10.3390/nu9101138
   Jomova K, 2011, TOXICOLOGY, V283, P65, DOI 10.1016/j.tox.2011.03.001
   Kaiser J., 2014, J. Syst. Integrat., P42, DOI [10.20470/jsi.v5i1.178, DOI 10.20470/JSI.V5I1.178]
   Kortenkamp A, 2007, ENVIRON HEALTH PERSP, V115, P98, DOI 10.1289/ehp.9357
   Lazarevic N, 2019, ENVIRON HEALTH PERSP, V127, DOI [10.1289/EHP2207, 10.1289/ehp2207]
   Lenters V, 2018, OCCUP ENVIRON MED, V75, P522, DOI 10.1136/oemed-2016-104231
   Li K, 2021, ENVIRON RES, V202, DOI 10.1016/j.envres.2021.111747
   Li LM, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/7580707
   Li XJ, 2019, ENVIRON INT, V126, P454, DOI 10.1016/j.envint.2019.02.048
   Li ZY, 2021, CHEMOSPHERE, V264, DOI 10.1016/j.chemosphere.2020.128505
   Li ZY, 2019, ENVIRON POLLUT, V255, DOI 10.1016/j.envpol.2019.113325
   Lind PM, 2013, ENVIRON INT, V55, P1, DOI 10.1016/j.envint.2013.01.017
   Liu G, 2015, INT J EPIDEMIOL, V44, P240, DOI 10.1093/ije/dyu200
   Liu XL, 2019, ENVIRON POLLUT, V254, DOI 10.1016/j.envpol.2019.113113
   Lo K, 2021, SCI TOTAL ENVIRON, V780, DOI 10.1016/j.scitotenv.2021.146527
   Lu CW, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020548
   Ma JX, 2020, ENVIRON INT, V140, DOI 10.1016/j.envint.2020.105802
   Mahurpawar M., 2015, INT J RES, P1, DOI DOI 10.29121/GRANTHAALAYAH.V3.I9SE.2015.3282
   Malnick S, 2013, NEW ENGL J MED, V369, P2456, DOI 10.1056/NEJMc1313169
   Martin O, 2021, ENVIRON INT, V146, DOI 10.1016/j.envint.2020.106206
   MERTZ W, 1981, SCIENCE, V213, P1332, DOI 10.1126/science.7022654
   Miao X, 2013, FRONT MED-PRC, V7, P31, DOI 10.1007/s11684-013-0251-9
   Ng SW, 2009, SOC SCI MED, V68, P1305, DOI 10.1016/j.socscimed.2009.01.035
   Nielsen FH, 1998, J TRACE ELEM EXP MED, V11, P251, DOI 10.1002/(SICI)1520-670X(1998)11:2/3<251::AID-JTRA15>3.0.CO;2-Q
   Nisse C, 2017, INT J HYG ENVIR HEAL, V220, P341, DOI 10.1016/j.ijheh.2016.09.020
   Noor N, 2018, ENVIRON INT, V121, P349, DOI 10.1016/j.envint.2018.08.029
   Nordberg G.F., 2014, HDB TOXICOLOGY METAL, V4th ed.
   Obeid O, 2008, BIOL TRACE ELEM RES, V123, P58, DOI 10.1007/s12011-008-8112-0
   Olechnowicz J, 2018, J PHYSIOL SCI, V68, P19, DOI 10.1007/s12576-017-0571-7
   Panchal SK, 2017, CURR HYPERTENS REP, V19, DOI 10.1007/s11906-017-0701-x
   Park SK, 2017, ENVIRON HEALTH-GLOB, V16, DOI 10.1186/s12940-017-0310-9
   Pizent A, 2010, J NUTR HEALTH AGING, V14, P866, DOI 10.1007/s12603-010-0139-1
   Planchart A, 2018, CURR ENV HLTH REP, V5, P110, DOI 10.1007/s40572-018-0182-3
   Poursafa P, 2014, ENVIRON SCI POLLUT R, V21, P13496, DOI 10.1007/s11356-014-3238-4
   Ranasinghe P, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4041-1
   Ruz M, 2019, BIOL TRACE ELEM RES, V188, P177, DOI 10.1007/s12011-018-1611-8
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Schisterman EF, 2017, EPIDEMIOLOGY, V28, P47, DOI 10.1097/EDE.0000000000000554
   Seo JA, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0105990
   Shan ZL, 2016, ENVIRON HEALTH PERSP, V124, P1876, DOI 10.1289/EHP176
   Shi YJ, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21072612
   Shim YH, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16040671
   Skogheim TS, 2021, ENVIRON INT, V152, DOI 10.1016/j.envint.2021.106468
   Soares SS, 2007, J INORG BIOCHEM, V101, P80, DOI 10.1016/j.jinorgbio.2006.08.002
   Spratlen MJ, 2018, AM J EPIDEMIOL, V187, P1598, DOI 10.1093/aje/kwy048
   Stangl GI, 1996, J NUTR, V126, P2466, DOI 10.1093/jn/126.10.2466
   Su H, 2017, INT J ENV RES PUB HE, V14, DOI 10.3390/ijerph14101164
   Sun ZC, 2013, ENVIRON HEALTH-GLOB, V12, DOI 10.1186/1476-069X-12-85
   Tchounwou P., 2012, MOL CLIN ENV TOXICOL, V101, P133, DOI DOI 10.1007/978-3-7643-8340-4
   Teixeira PDD, 2020, THER ADV ENDOCRINOL, V11, DOI 10.1177/2042018820917869
   Trumbo P, 2001, J AM DIET ASSOC, V101, P294, DOI 10.1016/S0002-8223(01)00078-5
   Van Ancum JM, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0206424
   Wang X, 2014, AM J EPIDEMIOL, V180, P378, DOI 10.1093/aje/kwu148
   Wang X, 2020, ENVIRON INT, V145, DOI 10.1016/j.envint.2020.106109
   Wang X, 2018, ENVIRON INT, V121, P683, DOI 10.1016/j.envint.2018.09.035
   Wang YX, 2016, ENVIRON HEALTH PERSP, V124, P468, DOI 10.1289/ehp.1409551
   Xi B, 2013, PREV MED, V57, P867, DOI 10.1016/j.ypmed.2013.09.023
   Xu P, 2021, ENVIRON POLLUT, V273, DOI 10.1016/j.envpol.2021.116480
   Xu YL, 2020, CHEMOSPHERE, V254, DOI 10.1016/j.chemosphere.2020.126763
   Xu Z., 2021, J HAZARD MAT LETT, V2
   Yary T, 2017, NUTRITION, V37, P43, DOI 10.1016/j.nut.2016.09.004
   Yoshida J, 2018, BMC PUBLIC HEALTH, V18, DOI 10.1186/s12889-018-6262-3
   Yu XD, 2014, ENVIRON RES, V133, P232, DOI 10.1016/j.envres.2014.04.012
   Yu YH, 2012, NUTR RES, V32, P71, DOI 10.1016/j.nutres.2011.12.004
   Yuan Y, 2014, NEUROL SCI, V35, P923, DOI 10.1007/s10072-014-1668-x
   Zanobetti A, 2014, ENVIRON INT, V71, P13, DOI 10.1016/j.envint.2014.05.023
   Zhang WCB, 2020, ENVIRON INT, V143, DOI 10.1016/j.envint.2020.105959
   Zhang ZH, 2016, ANN TRANSL MED, V4, DOI 10.3978/j.issn.2305-5839.2015.12.38
   Zhao H, 2020, SCI TOTAL ENVIRON, V742, DOI 10.1016/j.scitotenv.2020.140613
   Zou H, 2005, J R STAT SOC B, V67, P301, DOI 10.1111/j.1467-9868.2005.00503.x
   Zou H, 2006, J AM STAT ASSOC, V101, P1418, DOI 10.1198/016214506000000735
NR 116
TC 19
Z9 20
U1 0
U2 39
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD JAN
PY 2022
VL 287
AR 132295
DI 10.1016/j.chemosphere.2021.132295
EA SEP 2021
PN 3
PG 10
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA WD5GN
UT WOS:000704969000004
PM 34563779
DA 2025-06-11
ER

PT J
AU Bordet, S
   Luaces, JP
   Herrera, MI
   Gonzalez, LM
   Kobiec, T
   Perez-Lloret, S
   Otero-Losada, M
   Capani, F
AF Bordet, Sofia
   Luaces, Juan Pablo
   Herrera, Maria Ines
   Gonzalez, Liliana Mirta
   Kobiec, Tamara
   Perez-Lloret, Santiago
   Otero-Losada, Matilde
   Capani, Francisco
TI Neuroprotection from protein misfolding in cerebral hypoperfusion
   concurrent with metabolic syndrome. A translational perspective
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Review
DE metabolic syndrome; type 2 diabetes; chronic cerebral hypoperfusion;
   protein misfolding; neurodegeneration; animal models
ID HIGH-FAT DIET; VASCULAR COGNITIVE IMPAIRMENT; DIABETES-MELLITUS;
   WOLFRAM-SYNDROME; ANIMAL-MODELS; ER STRESS; RODENT MODELS; MOUSE MODEL;
   WFS1 GENE; OBESITY
AB Based on clinical and experimental evidence, metabolic syndrome (MetS) and type 2 diabetes (T2D) are considered risk factors for chronic cerebral hypoperfusion (CCH) and neurodegeneration. Scientific evidence suggests that protein misfolding is a potential mechanism that explains how CCH can lead to either Alzheimer's disease (AD) or vascular cognitive impairment and dementia (VCID). Over the last decade, there has been a significant increase in the number of experimental studies regarding this issue. Using several animal paradigms and different markers of CCH, scientists have discussed the extent to which MetSor T2D causes a decrease in cerebral blood flow (CBF). In addition, different models of CCH have explored how long-term reductions in oxygen and energy supply can trigger AD or VCID via protein misfolding and aggregation. Research that combines two or three animal models could broaden knowledge of the links between these pathological conditions. Recent experimental studies suggest novel neuroprotective properties of protein-remodeling factors. In this review, we present a summarized updated revision of preclinical findings, discussing clinical implications and proposing new experimental approaches from a translational perspective. We are confident that research studies, both clinical and experimental, may find new diagnostic and therapeutic tools to prevent neurodegeneration associated with MetS, diabetes, and any other chronic non-communicable disease (NCD) associated with diet and lifestyle risk factors.
C1 [Bordet, Sofia; Luaces, Juan Pablo; Herrera, Maria Ines; Gonzalez, Liliana Mirta; Kobiec, Tamara; Otero-Losada, Matilde; Capani, Francisco] Univ Abierta Interamer, Ctr Altos Estudios Ciencias Humanas & Salud, Consejo Nacl Invest Cient & Tecn, CAECIHS,UAI CONICET, Buenos Aires, Argentina.
   [Bordet, Sofia; Herrera, Maria Ines; Kobiec, Tamara] Pontificia Univ Catolica Argentina UCA, Fac Psicol & Psicopedag, Ctr Invest Psicol & Psicopedag CIPP, Buenos Aires, Argentina.
   [Perez-Lloret, Santiago] Univ Buenos Aires UBA, Fac Med, Dept Fisiol, Buenos Aires, Argentina.
   [Perez-Lloret, Santiago] Pontificia Univ Catolica Argentina, Consejo Nacl Invest Cient & Tecn, Observ Salud Publ, Buenos Aires, Argentina.
   [Capani, Francisco] Univ Autonoma Chile, Fac Ciencias Salud, Inst Ciencias Biomed, Santiago, Chile.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   Pontificia Universidad Catolica Argentina; University of Buenos Aires;
   Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   Pontificia Universidad Catolica Argentina; Universidad Autonoma de Chile
RP Capani, F (corresponding author), Univ Abierta Interamer, Ctr Altos Estudios Ciencias Humanas & Salud, Consejo Nacl Invest Cient & Tecn, CAECIHS,UAI CONICET, Buenos Aires, Argentina.; Capani, F (corresponding author), Univ Autonoma Chile, Fac Ciencias Salud, Inst Ciencias Biomed, Santiago, Chile.
EM franciscocapani@hotmail.com
RI capani, Francisco/D-9781-2016; Luaces, Juan/NDT-5206-2025
FU COFECyT [PF103 2022-262,025, PICT-2020-SERIEA-01926]
FX This work was supported by grants to FC from COFECyT PF103 2022-262,025,
   PS1 UAI 2023-2025, UK 2023-2025, PICT-2020-SERIEA-01926.
CR Abdel-Megeid FY, 2011, SAUDI MED J, V32, P621
   Ahima RS, 2000, ANNU REV PHYSIOL, V62, P413, DOI 10.1146/annurev.physiol.62.1.413
   de Artiñano AA, 2009, BRIT J NUTR, V102, P1246, DOI 10.1017/S0007114509990729
   Amer Diabet Assoc, 2002, DIABETES CARE, V25, P213
   Barale C, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21020623
   Bruce KD, 2010, J NUTR, V140, P648, DOI 10.3945/jn.109.111179
   Chapla A, 2022, J CLIN ENDOCR METAB, V107, P1328, DOI 10.1210/clinem/dgac002
   Chen S, 2023, NEURAL REGEN RES, V18, P1501, DOI 10.4103/1673-5374.361540
   Chen S, 2022, ACTA NEUROPATHOL, V143, P547, DOI 10.1007/s00401-022-02417-4
   Chen TT, 2021, AGING-US, V13, P9542, DOI 10.18632/aging.202667
   Chen Y, 2023, FRONT GENET, V14, DOI 10.3389/fgene.2023.1072978
   Ciechanover A, 2015, EXP MOL MED, V47, DOI 10.1038/emm.2014.117
   COLEMAN DL, 1978, DIABETOLOGIA, V14, P141, DOI 10.1007/BF00429772
   da Silva DC, 2020, PHARMACOL RES, V155, DOI 10.1016/j.phrs.2020.104702
   Doria A, 2013, NEW ENGL J MED, V368, P1845, DOI 10.1056/NEJMc1303158
   Duncombe J, 2017, CLIN SCI, V131, P2451, DOI 10.1042/CS20160727
   Esiri MM, 2001, LANCET, V357, P169
   Farooqui AA, 2012, CELL MOL LIFE SCI, V69, P741, DOI 10.1007/s00018-011-0840-1
   Furman Brian L, 2021, Curr Protoc, V1, pe78, DOI 10.1002/cpz1.78
   Gomez-Smith M, 2018, NEUROSCIENCE, V371, P166, DOI 10.1016/j.neuroscience.2017.11.054
   Gong YY, 2021, BMC ENDOCR DISORD, V21, DOI 10.1186/s12902-021-00748-z
   Gooch J, 2016, CELL MOL NEUROBIOL, V36, P233, DOI 10.1007/s10571-015-0286-3
   Goyal SN, 2016, CHEM-BIOL INTERACT, V244, P49, DOI 10.1016/j.cbi.2015.11.032
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Hai J, 2013, NEUROL RES, V35, P734, DOI 10.1179/1743132812Y.0000000154
   Haluzík M, 2000, PHYSIOL RES, V49, pS37
   Herrera M. I., 2020, Neuroprotection-New Approaches Prospects, V2020, P1, DOI [10.5772/intechopen.92603, DOI 10.5772/INTECHOPEN.92603]
   Herrera MI, 2018, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00339
   Herrera MI, 2018, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00145
   Hetz C, 2017, NAT REV NEUROL, V13, P477, DOI 10.1038/nrneurol.2017.99
   Hypoperfusion CC, 2021, INT IMMUNOPHARMACOL, V93, DOI 10.1016/j.intimp.2021.107422
   Jia YQ, 2015, CELL MOL BIOL LETT, V20, P475, DOI 10.1515/cmble-2015-0027
   Karasawa H, 2009, METABOLISM, V58, P296, DOI 10.1016/j.metabol.2008.09.028
   Kastin AJ, 1999, PEPTIDES, V20, P1449, DOI 10.1016/S0196-9781(99)00156-4
   Katakam PVG, 2009, AM J PHYSIOL-REG I, V296, pR289, DOI 10.1152/ajpregu.90656.2008
   KAWANO K, 1992, DIABETES, V41, P1422, DOI 10.2337/diabetes.41.11.1422
   Kazamel M, 2021, MUSCLE NERVE, V63, P285, DOI 10.1002/mus.27086
   Kim JE, 2022, MOLECULES, V27, DOI 10.3390/molecules27020334
   King A, 2016, BIOCHEM PHARMACOL, V99, P1, DOI 10.1016/j.bcp.2015.08.108
   Kitamura A, 2012, NEUROBIOL AGING, V33, DOI 10.1016/j.neurobiolaging.2011.10.033
   Kleinert M, 2018, NAT REV ENDOCRINOL, V14, P140, DOI 10.1038/nrendo.2017.161
   Kwon Hyokjoon, 2013, Front Endocrinol (Lausanne), V4, P71, DOI 10.3389/fendo.2013.00071
   Lai M, 2014, NUTR DIABETES, V4, DOI 10.1038/nutd.2014.30
   Li LP, 2020, NEUROSCI BIOBEHAV R, V118, P775, DOI 10.1016/j.neubiorev.2020.09.011
   Li YM, 2017, BIOL PHARM BULL, V40, P249, DOI 10.1248/bpb.b16-00567
   Liu L, 2015, SCI REP-UK, V5, DOI 10.1038/srep14474
   Livingston G, 2020, LANCET, V396, P413, DOI 10.1016/S0140-6736(20)30367-6
   Livingston JM, 2020, NEUROBIOL DIS, V137, DOI 10.1016/j.nbd.2020.104756
   Lutz TA, 2020, METHODS MOL BIOL, V2128, P11, DOI 10.1007/978-1-0716-0385-7_2
   Lynch CM, 2013, STROKE, V44, P3195, DOI 10.1161/STROKEAHA.113.001366
   McCrimmon RJ, 2012, LANCET, V379, P2291, DOI 10.1016/S0140-6736(12)60360-2
   Michaelis O E, 1989, Nutrition, V5, P56
   Niedowicz DM, 2014, ACTA NEUROPATHOL COM, V2, DOI 10.1186/2051-5960-2-64
   Nishijima Y, 2016, STROKE, V47, P3014, DOI 10.1161/STROKEAHA.116.014882
   Obrosova IG, 2007, DIABETES, V56, P2598, DOI 10.2337/db06-1176
   Opatrilova R, 2018, BIOMED PHARMACOTHER, V98, P424, DOI 10.1016/j.biopha.2017.12.074
   Osmond JM, 2009, HYPERTENSION, V53, P381, DOI 10.1161/HYPERTENSIONAHA.108.124149
   Otero-Losada M, 2016, MEDIAT INFLAMM, V2016, DOI 10.1155/2016/5613056
   Otero-Losada M, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0155630
   Otero-Losada M, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0118700
   Otero-Losada M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0089838
   Otero-Losada ME, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-57
   Otero-Losada ME, 2011, INT J CARDIOL, V146, P106, DOI 10.1016/j.ijcard.2010.09.066
   Ozacmak VH, 2009, J PINEAL RES, V47, P156, DOI 10.1111/j.1600-079X.2009.00695.x
   Pandey S, 2020, ENDOCR METAB IMMUNE, V20, P25, DOI 10.2174/1871530319666190626143832
   Panfili E, 2021, HUM MOL GENET, V30, P265, DOI 10.1093/hmg/ddab040
   Phillips MS, 1996, NAT GENET, V13, P18, DOI 10.1038/ng0596-18
   Picó C, 2002, OBES RES, V10, P932, DOI 10.1038/oby.2002.127
   Ramos-Lobo Angela M, 2017, Temperature (Austin), V4, P258, DOI 10.1080/23328940.2017.1327003
   Russo Isabella, 2012, Scientifica (Cairo), V2012, P525374, DOI 10.6064/2012/525374
   Shibata M, 2004, STROKE, V35, P2598, DOI 10.1161/01.STR.0000143725.19053.60
   Skovso S, 2014, J DIABETES INVEST, V5, P349, DOI 10.1111/jdi.12235
   Suriano F, 2021, MICROBIOME, V9, DOI 10.1186/s40168-021-01097-8
   Szkudelski T, 2012, EXP BIOL MED, V237, P481, DOI 10.1258/ebm.2012.011372
   Takeda S, 2010, P NATL ACAD SCI USA, V107, P7036, DOI 10.1073/pnas.1000645107
   van Golen LW, 2013, DIABETES, V62, P2898, DOI 10.2337/db12-1159
   Wang DP, 2017, NEUROSCIENCE, V344, P293, DOI 10.1016/j.neuroscience.2016.12.034
   Wei Michael, 2003, Heart Lung Circ, V12, P44, DOI 10.1046/j.1444-2892.2003.00160.x
   Winzell MS, 2004, DIABETES, V53, pS215, DOI 10.2337/diabetes.53.suppl_3.S215
   Wisloff U, 2005, SCIENCE, V307, P418, DOI 10.1126/science.1108177
   Zhang JW, 2020, J NEUROINFLAMM, V17, DOI 10.1186/s12974-019-1688-9
   Zhang M, 2008, EXP DIABETES RES, DOI 10.1155/2008/704045
   Zhang T, 2009, NEUROSCIENCE, V161, P1045, DOI 10.1016/j.neuroscience.2009.04.032
   Zhao Y, 2015, CELL MOL NEUROBIOL, V35, P101, DOI 10.1007/s10571-014-0127-9
   Zuloaga KL, 2016, J CEREBR BLOOD F MET, V36, P1257, DOI 10.1177/0271678X15616400
NR 85
TC 1
Z9 1
U1 1
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD AUG 15
PY 2023
VL 17
AR 1215041
DI 10.3389/fnins.2023.1215041
PG 7
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA Q7DD4
UT WOS:001059082400001
PM 37650104
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Caiati, C
   Stanca, A
   Lepera, ME
AF Caiati, Carlo
   Stanca, Alessandro
   Lepera, Mario Erminio
TI Free Radicals and Obesity-Related Chronic Inflammation Contrasted by
   Antioxidants: A New Perspective in Coronary Artery Disease
SO METABOLITES
LA English
DT Review
DE metabolic syndrome; antioxidants; free radicals; coronary
   atherosclerosis; oxidized LDL; toxicity
ID NF-KAPPA-B; ALL-CAUSE MORTALITY; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; ENDOTHELIAL DYSFUNCTION; CIGARETTE-SMOKING;
   DIETARY ANTIOXIDANTS; INSULIN-RESISTANCE; METABOLIC SYNDROME; AMALGAM
   FILLINGS
AB We are surrounded by factors called free radicals (FR), which attach to the molecules our body is made of, first among them the endothelium. Even though FR are to a certain extent a normal factor, nowadays we face an escalating increase in these biologically aggressive molecules. The escalating formation of FR is linked to the increased usage of man-made chemicals for personal care (toothpaste, shampoo, bubble bath, etc.), domestic laundry and dish-washer detergents, and also an ever wider usage of drugs (both prescription and over the counter), especially if they are to be used long-term (years). In addition, tobacco smoking, processed foods, pesticides, various chronic infectious microbes, nutritional deficiencies, lack of sun exposure, and, finally, with a markedly increasing impact, electromagnetic pollution (a terribly destructive factor), can increase the risk of cancer, as well as endothelial dysfunction, owing to the increased production of FR that they cause. All these factors create endothelial damage, but the organism may be able to repair such damage thanks to the intervention of the immune system supported by antioxidants. However, one other factor can perpetuate the state of inflammation, namely obesity and metabolic syndrome with associated hyperinsulinemia. In this review, the role of FR, with a special emphasis on their origin, and of antioxidants, is explored from the perspective of their role in causing atherosclerosis, in particular at the coronary level.
C1 [Caiati, Carlo; Stanca, Alessandro; Lepera, Mario Erminio] Univ Bari Aldo Moro, Dept Interdisciplinary Med, Unit Cardiovasc Dis, I-70124 Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro
RP Caiati, C (corresponding author), Univ Bari Aldo Moro, Dept Interdisciplinary Med, Unit Cardiovasc Dis, I-70124 Bari, Italy.
EM carlo.caiati@uniba.it; alessandrostanca@gmail.com;
   marioerminio.lepera@uniba.it
RI caiati, carlo/AAG-3971-2021
OI Caiati, Carlo/0000-0002-7447-575X; Stanca,
   Alessandro/0009-0002-0512-7572
CR Aburto NJ, 2013, BMJ-BRIT MED J, V346, DOI [10.1136/bmj.f1326, 10.1136/bmj.f1378]
   Aggarwal BB, 2009, INT J BIOCHEM CELL B, V41, P40, DOI 10.1016/j.biocel.2008.06.010
   Ahmed H., 2012, J BAGHDAD COLL DENT, V24, P63
   Aiyer HS, 2008, NUTR CANCER, V60, P227, DOI 10.1080/01635580701624712
   Al Suwaidi J, 2000, CIRCULATION, V101, P948, DOI 10.1161/01.CIR.101.9.948
   Al-Saleh I, 2012, SCI TOTAL ENVIRON, V431, P188, DOI 10.1016/j.scitotenv.2012.05.036
   Anestopoulos I, 2020, PHARMACEUTICS, V12, DOI 10.3390/pharmaceutics12070688
   Arfaoui L, 2021, MOLECULES, V26, DOI 10.3390/molecules26102959
   Asami DK, 2003, J AGR FOOD CHEM, V51, P1237, DOI 10.1021/jf020635c
   Asgary S, 2017, CHEMOSPHERE, V180, P540, DOI 10.1016/j.chemosphere.2017.03.069
   BABIOR BM, 1984, J CLIN INVEST, V73, P599, DOI 10.1172/JCI111249
   Baby B, 2018, CRIT REV FOOD SCI, V58, P2491, DOI 10.1080/10408398.2017.1329198
   Bahadoran Z, 2013, J DIABETES METAB DIS, V12, DOI 10.1186/2251-6581-12-43
   Baker RG, 2011, CELL METAB, V13, P11, DOI 10.1016/j.cmet.2010.12.008
   Bakonyi T, 2004, J SPORT SCI MED, V3, P64
   Basu A, 2010, NUTR REV, V68, P168, DOI 10.1111/j.1753-4887.2010.00273.x
   Berlett BS, 1997, J BIOL CHEM, V272, P20313, DOI 10.1074/jbc.272.33.20313
   BHAUMIK G, 1995, INT J BIOMETEOROL, V38, P171, DOI 10.1007/BF01245384
   Blomhoff R, 2006, BRIT J NUTR, V96, pS52, DOI 10.1017/BJN20061864
   Boelsterli UA, 2003, TOXICOL APPL PHARM, V192, P307, DOI 10.1016/S0041-008X(03)00368-5
   BOGATY P, 1994, CIRCULATION, V90, P5, DOI 10.1161/01.CIR.90.1.5
   Boyer J, 2004, NUTR J, V3, DOI 10.1186/1475-2891-3-5
   Bralley J.A., 2001, LAB EVALUATIONS MOL, P276
   Cadenas E, 2000, FREE RADICAL BIO MED, V29, P222, DOI 10.1016/S0891-5849(00)00317-8
   Caiati C, 2023, ENDOCR METAB IMMUNE, V23, P1365, DOI 10.2174/1871530323666230416153426
   Caiati C, 2023, ENDOCR METAB IMMUNE, V23, P1359, DOI 10.2174/1871530323666230411142308
   Caiati C, 2023, DIAGNOSTICS, V13, DOI 10.3390/diagnostics13040670
   Caiati C, 2022, DIAGNOSTICS, V12, DOI 10.3390/diagnostics12092173
   Caiati C, 2022, ENDOCR METAB IMMUNE, V22, P970, DOI 10.2174/1381612828666220412093734
   Caiati C, 2020, CORONARY ARTERY DIS, V31, P500, DOI 10.1097/MCA.0000000000000873
   Caiati C, 2020, ENDOCR METAB IMMUNE, V20, P489, DOI 10.2174/1871530319666191015191614
   Caiati C, 2019, JACC-CARDIOVASC IMAG, V12, P1441, DOI 10.1016/j.jcmg.2018.06.029
   Caiati C, 2009, EUR HEART J, V30, P1797, DOI 10.1093/eurheartj/ehp163
   Carr AC, 2013, NUTRIENTS, V5, P4284, DOI 10.3390/nu5114284
   Cassidy A, 2013, CIRCULATION, V127, P188, DOI 10.1161/CIRCULATIONAHA.112.122408
   Chandraratna PAN, 1999, AM J CARDIOL, V84, P1362, DOI 10.1016/S0002-9149(99)00576-7
   Chen B, 2007, CARDIOVASC TOXICOL, V7, P114, DOI 10.1007/s12012-007-0005-5
   Cheynier V, 2005, AM J CLIN NUTR, V81, p223S, DOI 10.1093/ajcn/81.1.223S
   Cubedo J, 2017, THROMB HAEMOSTASIS, V117, P1816, DOI 10.1160/TH17-03-069
   CZERNIN J, 1995, CIRCULATION, V91, P2891, DOI 10.1161/01.CIR.91.12.2891
   Davies KJA, 1995, BIOCHEM SOC SYMP, P1, DOI 10.1042/bss0610001
   Desai NR, 2009, REPROD BIOL ENDOCRIN, V7, DOI 10.1186/1477-7827-7-114
   Dias MC, 2021, MOLECULES, V26, DOI 10.3390/molecules26175377
   Dizdaroglu M, 2002, FREE RADICAL BIO MED, V32, P1102, DOI 10.1016/S0891-5849(02)00826-2
   Donia T, 2021, ENVIRON SCI POLLUT R, V28, P34121, DOI 10.1007/s11356-021-14109-9
   DRASCH G, 1994, EUR J PEDIATR, V153, P607, DOI 10.1007/BF02190671
   Dumas O, 2020, EXPERT REV RESP MED, V14, P1, DOI 10.1080/17476348.2020.1689123
   Dumas O, 2015, EUR RESPIR J, V46, P258, DOI 10.1183/09031936.00177614
   ELBOUSTANI S, 1989, METABOLISM, V38, P315, DOI 10.1016/0026-0495(89)90117-0
   Cabaña-Muñoz ME, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0126339
   Farkhondeh T, 2020, BIOL TRACE ELEM RES, V196, P27, DOI 10.1007/s12011-019-01899-w
   Ferdous UT, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.593116
   Fernandez DM, 2022, NAT REV CARDIOL, V19, P43, DOI 10.1038/s41569-021-00589-2
   Flanagan SW, 1998, FEBS LETT, V431, P285, DOI 10.1016/S0014-5793(98)00779-0
   Foronjy Robert, 2006, Clin Appl Immunol Rev, V6, P53, DOI 10.1016/j.cair.2006.04.002
   Frijhoff J, 2015, ANTIOXID REDOX SIGN, V23, P1144, DOI 10.1089/ars.2015.6317
   Gallo G, 2018, INT J CARDIOL, V268, P27, DOI 10.1016/j.ijcard.2018.05.046
   Golovchenko I, 2000, CIRC RES, V87, P746, DOI 10.1161/01.RES.87.9.746
   Gong H, 2022, CYTA-J FOOD, V20, P111, DOI 10.1080/19476337.2022.2093400
   Grau-Perez M, 2022, ARTERIOSCL THROM VAS, V42, P87, DOI 10.1161/ATVBAHA.121.316358
   Grosso G, 2022, NUTRIENTS, V14, DOI 10.3390/nu14030545
   Gui YZ, 2022, FRONT CARDIOVASC MED, V9, DOI 10.3389/fcvm.2022.845942
   Gulcin I, 2022, PROCESSES, V10, DOI 10.3390/pr10010132
   Gunathilake KDPP, 2018, ANTIOXIDANTS-BASEL, V7, DOI 10.3390/antiox7090117
   Guzik TJ, 2000, CIRC RES, V86, pE85, DOI 10.1161/01.RES.86.9.e85
   Guzzi G, 2006, AM J FOREN MED PATH, V27, P42, DOI 10.1097/01.paf.0000201177.62921.c8
   Halcox JPJ, 2002, CIRCULATION, V106, P653, DOI 10.1161/01.CIR.0000025404.78001.D8
   Hansen GM, 2016, AM J CARDIOL, V118, P489, DOI 10.1016/j.amjcard.2016.05.036
   Hardell L, 2007, OCCUP ENVIRON MED, V64, P626, DOI 10.1136/oem.2006.029751
   Hardell L, 2010, NEUROEPIDEMIOLOGY, V35, P109, DOI 10.1159/000311044
   HARMAN D, 1956, J GERONTOL, V11, P298, DOI 10.1093/geronj/11.3.298
   He FJ, 2007, J HUM HYPERTENS, V21, P717, DOI 10.1038/sj.jhh.1002212
   Ho E, 2013, REDOX BIOL, V1, P483, DOI 10.1016/j.redox.2013.07.006
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Huang X, 2019, FOOD SCI BIOTECHNOL, V28, P1275, DOI 10.1007/s10068-019-00631-7
   Husain S, 2023, FRONT AGING-LAUSANNE, V4, DOI 10.3389/fragi.2023.1085511
   Jedrychowski W, 2006, ANN EPIDEMIOL, V16, P439, DOI 10.1016/j.annepidem.2005.06.059
   Jiménez-Monreal AM, 2009, J FOOD SCI, V74, pH97, DOI 10.1111/j.1750-3841.2009.01091.x
   Juni RP, 2013, J AM COLL CARDIOL, V61, P1471, DOI 10.1016/j.jacc.2012.11.068
   Jurenka JS, 2009, ALTERN MED REV, V14, P141
   Kanakis CD, 2005, J BIOMOL STRUCT DYN, V22, P719, DOI 10.1080/07391102.2005.10507038
   Kennedy A, 2009, J NUTR, V139, P1, DOI 10.3945/jn.108.098269
   Khalesi S, 2014, EUR J NUTR, V53, P1299, DOI 10.1007/s00394-014-0720-1
   Khan SU, 2019, ANN INTERN MED, V171, P190, DOI 10.7326/M19-0341
   Kim JK, 2012, CIRCULATION, V125, P1081, DOI 10.1161/CIRCULATIONAHA.111.090134
   Kiray A, 2013, TOXICOL IND HEALTH, V29, P418, DOI 10.1177/0748233711434957
   Kivrak Elfide Gizem, 2017, J Microsc Ultrastruct, V5, P167, DOI 10.1016/j.jmau.2017.07.003
   Kodama M, 1997, ANTICANCER RES, V17, P439
   Kong ASY, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11061175
   Korkina LG, 2007, CELL MOL BIOL, V53, P15, DOI 10.1170/T772
   Kousmine C., 1992, SALVATE VOSTRO CORPO, P283
   Kozakiewicz M, 2019, CLIN INTERV AGING, V14, P763, DOI 10.2147/CIA.S201250
   Kumar J, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00693
   Kurita-Ochiai T, 2015, ANTIOXIDANTS-BASEL, V4, P577, DOI 10.3390/antiox4030577
   Kurutas EB, 2016, NUTR J, V15, DOI 10.1186/s12937-016-0186-5
   Laforge M, 2020, NAT REV IMMUNOL, V20, P515, DOI 10.1038/s41577-020-0407-1
   Larsson K, 2014, ENVIRON INT, V73, P323, DOI 10.1016/j.envint.2014.08.014
   Ledda C, 2021, J OCCUP MED TOXICOL, V16, DOI 10.1186/s12995-020-00290-z
   Leishman Shaneen J, 2010, J Oral Microbiol, V2, DOI 10.3402/jom.v2i0.5781
   Leopold JA, 2015, CORONARY ARTERY DIS, V26, P176, DOI 10.1097/MCA.0000000000000187
   Levine TB., 2006, Metabolic syndrome and cardiovascular disease
   Li H, 2023, J HAZARD MATER, V442, DOI 10.1016/j.jhazmat.2022.130087
   Li X, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/8815048
   Liao QL, 2022, CHEMOSPHERE, V308, DOI 10.1016/j.chemosphere.2022.136394
   Lim S, 2020, SCI TOTAL ENVIRON, V742, DOI 10.1016/j.scitotenv.2020.140640
   Lin Y, 2020, PHYTOTHER RES, V34, P2459, DOI 10.1002/ptr.6697
   Litvinova L, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00020
   Liu DC, 2016, ONCOTARGET, V7, P85592, DOI 10.18632/oncotarget.12243
   Liu G, 2019, CIRC RES, V124, P920, DOI 10.1161/CIRCRESAHA.118.314316
   Liu JL, 2014, ENVIRON RES, V131, P160, DOI 10.1016/j.envres.2014.03.004
   Liu JK, 1996, FASEB J, V10, P1532, DOI 10.1096/fasebj.10.13.8940299
   Liu XR, 2020, J AM HEART ASSOC, V9, DOI 10.1161/JAHA.119.013877
   Lobo V, 2010, Pharmacogn Rev, V4, P118, DOI 10.4103/0973-7847.70902
   Lozano-Paniagua D, 2018, ECOTOX ENVIRON SAFE, V162, P121, DOI 10.1016/j.ecoenv.2018.06.074
   Ludwig DS, 2002, JAMA-J AM MED ASSOC, V287, P2414, DOI 10.1001/jama.287.18.2414
   Macri AM, 2021, MICROORGANISMS, V9, DOI 10.3390/microorganisms9010061
   Madrau MA, 2009, EUR FOOD RES TECHNOL, V228, P441, DOI 10.1007/s00217-008-0951-6
   Magrone T, 2018, CURR PHARM DESIGN, V24, P5229, DOI 10.2174/138161282444190329154418
   Mahalakshmi K, 2017, ANAEROBE, V44, P66, DOI 10.1016/j.anaerobe.2017.02.003
   Manal Azat A., 2019, ANTIOXIDANTS-BASEL
   Mantle D., 1999, Adverse Drug Reactions and Toxicological Reviews, V18, P235
   Mashhadi NS, 2013, INT J PREVENTIVE MED, V4, pS1
   Matsuzawa Y, 2014, CORONARY ARTERY DIS, V25, P713, DOI 10.1097/MCA.0000000000000178
   Matsuzawa Y, 2013, CIRC J, V77, P2807, DOI 10.1253/circj.CJ-13-0549
   McCully KS, 2020, ANN CLIN LAB SCI, V50, P408
   McGranaghan P, 2020, BIOMARKERS, V25, P101, DOI 10.1080/1354750X.2020.1716073
   Medina-Leyte DJ, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22083850
   Medina-Ramón M, 2005, OCCUP ENVIRON MED, V62, P598, DOI 10.1136/oem.2004.017640
   Miller JW, 1996, FREE RADICAL BIO MED, V21, P241, DOI 10.1016/0891-5849(96)00033-0
   Miller YI, 2010, SUBCELL BIOCHEM, V51, P229, DOI 10.1007/978-90-481-8622-8_8
   Mink PJ, 2007, AM J CLIN NUTR, V85, P895, DOI 10.1093/ajcn/85.3.895
   Moldogazieva NT, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/3085756
   Morgan MJ, 2011, CELL RES, V21, P103, DOI 10.1038/cr.2010.178
   Moriyama M, 2004, BIOFACTORS, V21, P247, DOI 10.1002/biof.552210147
   Moyer VA, 2014, ANN INTERN MED, V160, P558, DOI 10.7326/M14-0198
   Mucha P, 2021, MOLECULES, V26, DOI 10.3390/molecules26164886
   Mudau M, 2012, CARDIOVASC J AFR, V23, DOI 10.5830/CVJA-2011-068
   Mujtaba SF, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10071008
   Niazi SA, 2022, MEDICINA-LITHUANIA, V58, DOI 10.3390/medicina58070931
   Niki E, 2011, J CLIN BIOCHEM NUTR, V48, P3, DOI 10.3164/jcbn.11-007FR
   Nobari H, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19010218
   On Young Keun, 2002, Korean J Intern Med, V17, P131
   Padayatty SJ, 2003, J AM COLL NUTR, V22, P18, DOI 10.1080/07315724.2003.10719272
   Panda P, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/9154295
   Pandey KB, 2009, OXID MED CELL LONGEV, V2, P270, DOI 10.4161/oxim.2.5.9498
   Park KC, 2022, ATHEROSCLEROSIS, V357, P14, DOI 10.1016/j.atherosclerosis.2022.08.003
   Park SB, 2023, J YEUNGNAM MED SCI, V40, P373, DOI 10.12701/jyms.2022.00955
   PELIKANOVA T, 1991, CLIN CHIM ACTA, V203, P329, DOI 10.1016/0009-8981(91)90305-V
   Pham-Huy Lien Ai, 2008, Int J Biomed Sci, V4, P89
   Phaniendra A, 2015, INDIAN J CLIN BIOCHE, V30, P11, DOI 10.1007/s12291-014-0446-0
   Pryor WA, 2006, AM J PHYSIOL-REG I, V291, pR491, DOI 10.1152/ajpregu.00614.2005
   Puertollano MA, 2011, CURR TOP MED CHEM, V11, P1752
   Rafiee Sahar, 2021, Adv Exp Med Biol, V1291, P165, DOI 10.1007/978-3-030-56153-6_10
   Ralapanawa U, 2021, J EPIDEMIOL GLOB HEA, V11, P169, DOI 10.2991/jegh.k.201217.001
   Ramakers JD, 2007, LIPIDS, V42, P687, DOI 10.1007/s11745-007-3071-3
   Raschi E, 2010, PHARMACOL THERAPEUT, V125, P196, DOI 10.1016/j.pharmthera.2009.10.002
   Reaven G, 2005, PANMINERVA MED, V47, P201
   Rosmond R, 2000, J INTERN MED, V247, P188, DOI 10.1046/j.1365-2796.2000.00603.x
   Saini RK, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11020239
   Salonen JT, 2000, ATHEROSCLEROSIS, V148, P265, DOI 10.1016/S0021-9150(99)00272-5
   Schächinger V, 2000, CIRCULATION, V101, P1899, DOI 10.1161/01.CIR.101.16.1899
   Scherlag Benjamin J, 2004, Cardiol Rev, V12, P85, DOI 10.1097/01.crd.0000094029.10223.2f
   Sears B., 2005, ANTIINFLAMMATIONE ZO, V1st ed., P297
   Sears B, 2011, J OBES, V2011, DOI 10.1155/2011/431985
   Shao BH, 2010, CHEM RES TOXICOL, V23, P447, DOI 10.1021/tx9003775
   SINGAL PK, 1982, CAN J PHYSIOL PHARM, V60, P1390, DOI 10.1139/y82-207
   Singh KV, 2020, ENVIRON SCI POLLUT R, V27, P19340, DOI 10.1007/s11356-020-07916-z
   Singh R, 2015, DIABETES-METAB RES, V31, P113, DOI 10.1002/dmrr.2558
   Singh S, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17207519
   Snopek L, 2018, MOLECULES, V23, DOI 10.3390/molecules23071684
   Soskic SS, 2011, OPEN CARDIOVASC MED, V5, P153, DOI 10.2174/1874192401105010153
   Srivastava KK, 2015, INDIAN J CLIN BIOCHE, V30, P3, DOI 10.1007/s12291-014-0441-5
   Stanhope KL, 2016, CRIT REV CL LAB SCI, V53, P52, DOI 10.3109/10408363.2015.1084990
   STEINBERG D, 1989, NEW ENGL J MED, V320, P915
   Steinberg D, 2009, J LIPID RES, V50, pS376, DOI 10.1194/jlr.R800087-JLR200
   Stirnimann G, 2010, SWISS MED WKLY, V140, P18, DOI 10.4414/smw.2010.13080
   Stull AJ, 2010, J NUTR, V140, P1764, DOI 10.3945/jn.110.125336
   SUGIISHI M, 1993, CIRCULATION, V87, P76, DOI 10.1161/01.CIR.87.1.76
   Sule RO, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/5563759
   Takagahara S, 2019, J PHARMACOL EXP THER, V371, P290, DOI 10.1124/jpet.119.259846
   Tonetti MS, 2009, J CLIN PERIODONTOL, V36, P15, DOI 10.1111/j.1600-051X.2009.01417.x
   Tyrrell RM, 1995, BIOCHEM SOC SYMP, P47, DOI 10.1042/bss0610047
   Valavanidis A, 2009, INT J ENV RES PUB HE, V6, P445, DOI 10.3390/ijerph6020445
   Valko M, 2006, CHEM-BIOL INTERACT, V160, P1, DOI 10.1016/j.cbi.2005.12.009
   Valko M, 2004, MOL CELL BIOCHEM, V266, P37, DOI 10.1023/B:MCBI.0000049134.69131.89
   Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
   Venables MC, 2008, AM J CLIN NUTR, V87, P778, DOI 10.1093/ajcn/87.3.778
   Vinson JA, 2012, FOOD FUNCT, V3, P134, DOI 10.1039/c2fo10152a
   Virtanen JK, 2005, ARTERIOSCL THROM VAS, V25, P228, DOI 10.1161/01.ATV.0000150040.20950.61
   Walia M, 2003, MED PRIN PRACT, V12, P1, DOI 10.1159/000068159
   Wang LS, 2008, CANCER LETT, V269, P281, DOI 10.1016/j.canlet.2008.05.020
   Wang TB, 2021, MICROVASC RES, V136, DOI 10.1016/j.mvr.2021.104148
   Waters D, 1996, CIRCULATION, V94, P614, DOI 10.1161/01.CIR.94.4.614
   Weiss TW, 2013, METABOLISM, V62, P1008, DOI 10.1016/j.metabol.2013.01.019
   Wong YK, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.713191
   Wu DF, 2003, ALCOHOL RES HEALTH, V27, P277
   Yamamoto A, 2023, EXP BIOL MED, V248, P271, DOI 10.1177/15353702221142616
   Yashiro H, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0166198
   Yuan JM, 1996, JAMA-J AM MED ASSOC, V275, P1646, DOI 10.1001/jama.275.21.1646
   ZEIHER AM, 1995, CIRCULATION, V92, P1094, DOI 10.1161/01.CIR.92.5.1094
   Zhou DH, 2014, AM J CLIN NUTR, V100, P270, DOI 10.3945/ajcn.113.079152
   Zhou K, 2012, J ONCOL, V2012, DOI 10.1155/2012/803294
   Zhu XQ, 2022, J HAZARD MATER, V436, DOI 10.1016/j.jhazmat.2022.129179
   Zimmer H, 2002, INT J HYG ENVIR HEAL, V205, P205, DOI 10.1078/1438-4639-00146
NR 204
TC 14
Z9 14
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD JUN
PY 2023
VL 13
IS 6
AR 712
DI 10.3390/metabo13060712
PG 23
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA K2MF1
UT WOS:001014825000001
PM 37367870
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wu, YQ
   Zhang, Y
   Jiao, JJ
AF Wu, Yuqi
   Zhang, Yu
   Jiao, Jingjing
TI The relationship between n-3 polyunsaturated fatty acids and telomere: A
   review on proposed nutritional treatment against metabolic syndrome and
   potential signaling pathways
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE n-3 polyunsaturated acids; metabolic syndrome; telomere; signaling
   pathway
ID OXIDATIVE STRESS; FISH-OIL; CARDIOVASCULAR-DISEASE; DOCOSAHEXAENOIC
   ACID; DNA-DAMAGE; INSULIN SENSITIVITY; ADIPOSE-TISSUE; UP-REGULATION;
   DOUBLE-BLIND; LENGTH
AB Metabolic syndrome (MetS), a cluster of metabolic abnormalities composed of central obesity, elevated blood pressure, glucose disturbances, hypercholesterolemia and dyslipidaemia, has increasingly become a public health problem in the 21st century worldwide. The dysfunction of telomeres, the repetitive DNA with highly conserved sequences (5 '-TTAGGG-3 '), is remarkably correlated with organismal aging, even suggesting a causal relationship with metabolic disorders. The health benefits of n-3 polyunsaturated fatty acids (PUFAs) in multiple disorders are associated with telomere length in evidence, which have recently drawn wide attention. However, functional targets and pathways for the associations of n-3 PUFAs and telomere with MetS remain scare. Few studies have summarized the role of n-3 PUFAs in DNA damage repair pathways, anti-inflammatory pathways, and redox balance, linking with telomere biology, and other potential telomere-related signaling pathways. This review aims to (i) elucidate how n-3 PUFAs ameliorate telomere attrition in the context of anti-oxidation and anti-inflammation; (ii) unravel the role of n-3 PUFAs in modulating telomere-related neuron dysfunction and regulating the neuro-endocrine-immunological network in MetS; (iii) epidemiologically implicate the associations of metabolic disorders and n-3 PUFAs with telomere length; and (iv) suggest promising biochemical approaches and advancing methodologies to overcome the inter-variation problem helpful for future research.
C1 [Wu, Yuqi; Zhang, Yu] Zhejiang Univ, Coll Biosyst Engn & Food Sci, Fuli Inst Food Sci,Zhejiang Key Lab Agrofood Proc, Natl Engn Lab Intelligent Food Technol & Equipmen, Hangzhou, Zhejiang, Peoples R China.
   [Jiao, Jingjing] Zhejiang Univ, Affiliated Hosp 2, Sch Publ Hlth, Dept Nutr,Dept Clin Nutr,Sch Med, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang University
RP Jiao, JJ (corresponding author), Zhejiang Univ, Affiliated Hosp 2, Sch Publ Hlth, Dept Nutr,Dept Clin Nutr,Sch Med, Hangzhou, Zhejiang, Peoples R China.
EM jingjingjiao@zju.edu.cn
RI Wu, Yu/AAX-8654-2020
OI Zhang, Yu/0000-0003-1025-906X; Jiao, Jingjing/0000-0003-4167-1567
FU National Natural Science Foundation of Zhejiang Province [LR18C200001]
FX National Natural Science Foundation of Zhejiang Province LR18C200001.
CR Ahmad F, 2016, CELL DEATH DIS, V7, DOI 10.1038/cddis.2016.117
   Akbari M, 2019, AGEING RES REV, V54, DOI 10.1016/j.arr.2019.100940
   Ali S, 2022, BIOMOL CONCEPTS, V13, P25, DOI 10.1515/bmc-2021-0024
   Almada M, 2016, REPRODUCTION, V152, P351, DOI 10.1530/REP-16-0364
   Augustine Titto, 2017, Genes Cancer, V8, P550, DOI 10.18632/genesandcancer.140
   Awada M, 2012, J LIPID RES, V53, P2069, DOI 10.1194/jlr.M026179
   Bak DH, 2015, SCI REP-UK, V5, DOI 10.1038/srep15465
   Balasubramanian P, 2019, GEROSCIENCE, V41, P13, DOI 10.1007/s11357-018-0048-5
   Balcerczyk A, 2014, MOLECULES, V19, P14794, DOI 10.3390/molecules190914794
   Banerjee B, 2013, NAT REV CARDIOL, V10, pE1, DOI 10.1038/nrcardio.2013.30-c1
   Barden A, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030175
   Belair CD, 1997, P NATL ACAD SCI USA, V94, P13677, DOI 10.1073/pnas.94.25.13677
   Bellenger J, 2019, BIOCHIMIE, V159, P66, DOI 10.1016/j.biochi.2019.01.017
   Bhattacharjee RN, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011873
   Bidu C, 2018, DIABETES, V67, P1512, DOI 10.2337/db17-1488
   Bilsland AE, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006459
   Borges MC, 2022, BMC MED, V20, DOI 10.1186/s12916-022-02399-w
   Boskovic M, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/5543025
   Brayner B, 2018, NUTRIENTS, V10, DOI 10.3390/nu10060758
   Brown KM, 2019, BIOCHEM BIOPHYS REP, V18, DOI 10.1016/j.bbrep.2019.100622
   Brown LH, 2020, CURR OPIN PHARMACOL, V52, P40, DOI 10.1016/j.coph.2020.04.009
   Casagrande S, 2019, BIOL LETTERS, V15, DOI 10.1098/rsbl.2018.0885
   Castillo RL, 2015, J BIOMED SCI, V22, DOI 10.1186/s12929-015-0112-8
   Chamoli M, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-18690-4
   Chang XL, 2020, NUTR J, V19, DOI 10.1186/s12937-020-00626-9
   Chen JN, 2017, ONCOTARGET, V8, P7301, DOI 10.18632/oncotarget.14236
   Chen XR, 2018, J NEUROINFLAMM, V15, DOI [10.1186/s12974-018-1151-3, 10.1186/s12974-017-0917-3]
   Chen Z, 2014, ONCOGENE, V33, P4548, DOI 10.1038/onc.2013.402
   Cheng FF, 2021, LANCET DIABETES ENDO, V9, P117, DOI 10.1016/S2213-8587(20)30365-X
   Choi J, 2008, BRAIN BEHAV IMMUN, V22, P600, DOI 10.1016/j.bbi.2007.12.004
   Conklin QA, 2019, PSYCHONEUROENDOCRINO, V100, pS11, DOI 10.1016/j.psyneuen.2018.12.052
   Correia-Melo Clara, 2014, Longev Healthspan, V3, P1, DOI 10.1186/2046-2395-3-1
   Dang Y, 2020, AGING CELL, V19, DOI 10.1111/acel.13060
   Dantzer R, 2018, PHYSIOL REV, V98, P477, DOI 10.1152/physrev.00039.2016
   Das UN, 2014, NUTRITION, V30, P1218, DOI 10.1016/j.nut.2014.04.001
   Demers G, 2020, INT J OBESITY, V44, P1936, DOI 10.1038/s41366-020-0623-6
   Farooqui AA, 2012, CELL MOL LIFE SCI, V69, P741, DOI 10.1007/s00018-011-0840-1
   Farzaneh-Far R, 2010, JAMA-J AM MED ASSOC, V303, P250, DOI 10.1001/jama.2009.2008
   Feng RB, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/7962948
   Ferreira M., 2020, BIORXIV, DOI [10.1101/2020.01.10.901603v1, DOI 10.1101/2020.01.10.901603V1]
   Freitas-Simoes TM, 2019, CLIN NUTR, V38, P958, DOI 10.1016/j.clnu.2018.02.011
   Gabriel EE, 2022, J AM STAT ASSOC, V117, P939, DOI 10.1080/01621459.2020.1832502
   Galiè S, 2020, ADV NUTR, V11, P576, DOI 10.1093/advances/nmz107
   Gao JL, 2019, J AGR FOOD CHEM, V67, P13269, DOI 10.1021/acs.jafc.9b05739
   Gao JL, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071699
   García-Calzón S, 2015, AM J CLIN NUTR, V102, P897, DOI 10.3945/ajcn.115.116863
   Gavande NS, 2020, NUCLEIC ACIDS RES, V48, P11536, DOI 10.1093/nar/gkaa934
   Ghareghomi S, 2021, BIOCHIMIE, V181, P12, DOI 10.1016/j.biochi.2020.11.015
   Gilbert K, 2015, EUR J PHARMACOL, V769, P147, DOI 10.1016/j.ejphar.2015.11.010
   Golpour P, 2020, DIABETES RES CLIN PR, V162, DOI 10.1016/j.diabres.2020.108120
   Grun LK, 2018, FREE RADICAL BIO MED, V129, P286, DOI 10.1016/j.freeradbiomed.2018.09.039
   Halade GV, 2019, METABOLISM, V96, P22, DOI 10.1016/j.metabol.2019.04.011
   Hall BM, 2016, AGING-US, V8, P1294, DOI 10.18632/aging.100991
   Hall WL, 2017, P NUTR SOC, V76, P408, DOI 10.1017/S0029665117000428
   Hayashi Y, 2018, BIOCHEM BIOPH RES CO, V496, P549, DOI 10.1016/j.bbrc.2018.01.064
   Haycock PC, 2017, JAMA ONCOL, V3, P636, DOI 10.1001/jamaoncol.2016.5945
   Holub A, 2020, NUTR METAB CARDIOVAS, V30, P1795, DOI 10.1016/j.numecd.2020.06.014
   Inoue T, 2017, BBA-MOL CELL BIOL L, V1862, P552, DOI 10.1016/j.bbalip.2017.02.010
   Ishikado A, 2010, BIOCHEM BIOPH RES CO, V402, P99, DOI 10.1016/j.bbrc.2010.09.124
   Jo D, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0207864
   Jurk D, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms5172
   Kaliannan K, 2019, COMMUN BIOL, V2, DOI 10.1038/s42003-019-0521-4
   Kalsbeek MJT, 2016, MOL CELL ENDOCRINOL, V438, P27, DOI 10.1016/j.mce.2016.09.028
   Kalstad AA, 2019, BMC GERIATR, V19, DOI 10.1186/s12877-019-1383-9
   Kamal S, 2020, LIFE SCI, V257, DOI 10.1016/j.lfs.2020.118115
   Kang JX, 2004, NATURE, V427, P504, DOI 10.1038/427504a
   Kang YH, 2018, CELL REP, V22, P3493, DOI 10.1016/j.celrep.2018.02.071
   Kansal S, 2012, NUTR CANCER, V64, P559, DOI 10.1080/01635581.2012.675619
   Kiecolt-Glaser JK, 2013, BRAIN BEHAV IMMUN, V28, P16, DOI 10.1016/j.bbi.2012.09.004
   Kim W, 2019, CELL METAB, V29, P856, DOI 10.1016/j.cmet.2018.12.023
   Kirchner H, 2017, GENES-BASEL, V8, DOI 10.3390/genes8070176
   Kones R, 2017, MED PRIN PRACT, V26, P497, DOI 10.1159/000485837
   Kuhlow D, 2010, AGING-US, V2, P650, DOI 10.18632/aging.100200
   Kurt A, 2016, J PHYSIOL BIOCHEM, V72, P679, DOI 10.1007/s13105-016-0506-4
   Le Foll C, 2007, AM J PHYSIOL-ENDOC M, V292, pE1223, DOI 10.1152/ajpendo.00446.2006
   Lee JM, 2016, NUTRIENTS, V8, DOI 10.3390/nu8010023
   Lee OH, 2011, MOL CELL PROTEOMICS, V10, DOI 10.1074/mcp.M110.001628
   Lew LC, 2019, BENEF MICROBES, V10, P883, DOI 10.3920/BM2019.0058
   Lin J, 2022, AGEING RES REV, V73, DOI 10.1016/j.arr.2021.101507
   Liu RQ, 2020, J CROHNS COLITIS, V14, P1581, DOI 10.1093/ecco-jcc/jjaa086
   Liu XY, 2022, FRONT NUTR, V8, DOI 10.3389/fnut.2021.779306
   Liu XY, 2021, BMC PEDIATR, V21, DOI 10.1186/s12887-020-02487-x
   Liu YL, 2013, J NUTR, V143, P1331, DOI 10.3945/jn.113.176255
   Loh NY, 2021, AGING CELL, V20, DOI 10.1111/acel.13445
   López-Vicario C, 2015, P NATL ACAD SCI USA, V112, P536, DOI 10.1073/pnas.1422590112
   Lung FW, 2007, PSYCHIAT GENET, V17, P195, DOI 10.1097/YPG.0b013e32808374f6
   Madrid AS, 2020, EUR J EPIDEMIOL, V35, P147, DOI 10.1007/s10654-019-00563-w
   Makino N, 2010, EXP CLIN CARDIOL, V15, pE128
   Makino N, 2009, AM J PHYSIOL-HEART C, V297, pH2188, DOI 10.1152/ajpheart.00421.2009
   Maleki M, 2020, LIFE SCI, V259, DOI 10.1016/j.lfs.2020.118341
   Mansoori A, 2015, J CLIN LIPIDOL, V9, P770, DOI 10.1016/j.jacl.2015.08.007
   Manzella N, 2018, AGING CELL, V17, DOI 10.1111/acel.12811
   Martínez P, 2013, CELL REP, V3, P2059, DOI 10.1016/j.celrep.2013.05.030
   Mathivanan A., 2016, J ALZHEIMERS DIS PAR, V06, P12, DOI [10.4172/2161-0460.1000213, DOI 10.4172/2161-0460.1000213]
   Mazidi M, 2017, POL ARCH INTERN MED, V127, P87, DOI 10.20452/pamw.3927
   McAninch D, 2020, DIABETOLOGIA, V63, P2140, DOI 10.1007/s00125-020-05242-0
   Méndez-Pertuz M, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01329-2
   Mollace V, 2013, INT J CARDIOL, V170, pS8, DOI 10.1016/j.ijcard.2013.06.038
   Monk JM, 2016, J NUTR BIOCHEM, V32, P29, DOI 10.1016/j.jnutbio.2016.01.004
   Muñoz-Lorente MA, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-12664-x
   Nilsson PM, 2014, NAT REV ENDOCRINOL, V10, P706, DOI 10.1038/nrendo.2014.182
   Nishi H, 2004, MOL CELL BIOL, V24, P6076, DOI 10.1128/MCB.24.13.6076-6083.2004
   Nishimura K, 2017, STEM CELL REP, V8, P787, DOI 10.1016/j.stemcr.2017.01.026
   O'Callaghan N, 2014, NUTRITION, V30, P489, DOI 10.1016/j.nut.2013.09.013
   Ogluszka M, 2020, ANIMALS-BASEL, V10, DOI 10.3390/ani10061090
   Ogretmen B, 2001, J BIOL CHEM, V276, P24901, DOI 10.1074/jbc.M100314200
   Oppedisano F, 2020, BIOMEDICINES, V8, DOI 10.3390/biomedicines8090306
   Pai VJ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0097637
   Palanissami G, 2018, HORM CANCER-US, V9, P295, DOI 10.1007/s12672-018-0342-9
   Pawelczyk T, 2018, PROG NEURO-PSYCHOPH, V83, P142, DOI 10.1016/j.pnpbp.2017.12.008
   Petri MH, 2018, JACC-BASIC TRANSL SC, V3, P719, DOI 10.1016/j.jacbts.2018.08.005
   Piplani Shobhit, 2021, Genome Integr, V12, P1, DOI 10.4103/genint.genint_1_21
   Pizzimenti S, 2006, FREE RADICAL BIO MED, V40, P1578, DOI 10.1016/j.freeradbiomed.2005.12.024
   Ponnusamy S, 2008, J BIOL CHEM, V283, P27514, DOI 10.1074/jbc.M802980200
   Ranasinghe P, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4041-1
   Rao JS, 2007, MOL PSYCHIATR, V12, P36, DOI 10.1038/sj.mp.4001888
   Révész D, 2015, J CLIN ENDOCR METAB, V100, P3050, DOI 10.1210/JC.2015-1995
   Révész D, 2014, J CLIN ENDOCR METAB, V99, P4607, DOI 10.1210/jc.2014-1851
   Rey C, 2016, BRAIN BEHAV IMMUN, V55, P249, DOI 10.1016/j.bbi.2015.12.013
   Roberts TL, 2013, P NATL ACAD SCI USA, V110, pE285, DOI 10.1073/pnas.1215696110
   Roqueta-Rivera M, 2010, J LIPID RES, V51, P360, DOI 10.1194/jlr.M001180
   Roy S, 2018, MUTAT RES-GEN TOX EN, V836, P89, DOI 10.1016/j.mrgentox.2018.05.018
   Rusinek K, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9051231
   Sakai C, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0187934
   Saretzki G, 2002, ANN NY ACAD SCI, V959, P24, DOI 10.1111/j.1749-6632.2002.tb02079.x
   Schmitz G, 2008, PROG LIPID RES, V47, P147, DOI 10.1016/j.plipres.2007.12.004
   Serini S, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030185
   Serini S, 2016, CURR ALZHEIMER RES, V13, P123, DOI 10.2174/1567205012666150921101147
   Shaheen F, 2014, BBA-MOL BASIS DIS, V1842, P1762, DOI 10.1016/j.bbadis.2014.06.018
   Shi JP, 2019, NEUROSCIENCE, V414, P112, DOI 10.1016/j.neuroscience.2019.06.027
   Singh RB, 2019, ROLE OF FUNCTIONAL FOOD SECURITY IN GLOBAL HEALTH, P681, DOI 10.1016/B978-0-12-813148-0.00040-2
   Singh RB, 2004, BIOMED PHARMACOTHER, V58, pS56, DOI 10.1016/S0753-3322(04)80011-8
   Smith JA, 2013, NEUROCHEM INT, V62, P764, DOI 10.1016/j.neuint.2013.02.013
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Song Y, 2013, J NUTR, V143, P907, DOI 10.3945/jn.113.175422
   Stemmer K, 2019, J CLIN INVEST, V129, P4058, DOI 10.1172/JCI129195
   Stetson B, 2009, NUTR HEALTH SER, P389, DOI 10.1007/978-1-60327-542-2_16
   Sun Grace Y, 2018, Prostaglandins Leukot Essent Fatty Acids, V136, P3, DOI 10.1016/j.plefa.2017.03.006
   Sundin T, 2012, EXPERT REV MOL MED, V14, DOI 10.1017/erm.2012.1
   Talamonti E, 2020, FASEB J, V34, P2024, DOI 10.1096/fj.201901890RR
   Tapia G, 2014, MOL NUTR FOOD RES, V58, P1333, DOI 10.1002/mnfr.201300458
   Tiainen AMK, 2012, EUR J CLIN NUTR, V66, P1290, DOI 10.1038/ejcn.2012.143
   Topiwala A, 2022, MOL PSYCHIATR, V27, P4001, DOI 10.1038/s41380-022-01690-9
   Toupchian O, 2018, CLIN NUTR, V37, P91, DOI 10.1016/j.clnu.2016.12.007
   Turner KJ, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8010073
   Vallabhaneni H, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003639
   van der Spek A, 2022, HUM MOL GENET, V31, P1159, DOI 10.1093/hmg/ddab281
   Varela-Lopez A, 2018, J NUTR BIOCHEM, V52, P36, DOI 10.1016/j.jnutbio.2017.09.007
   Vlachos II, 2020, BRAIN SCI, V10, DOI 10.3390/brainsci10030173
   Wainwright CL, 2013, P NUTR SOC, V72, P460, DOI 10.1017/S0029665113003406
   Wang M, 2017, BBA-MOL BASIS DIS, V1863, P3190, DOI 10.1016/j.bbadis.2017.08.026
   Warner DR, 2021, FASEB J, V35, DOI 10.1096/fj.202001202R
   Wijayabahu AT, 2022, NUTRIENTS, V14, DOI 10.3390/nu14020266
   Wu LL, 2020, PHARMACOL RES, V155, DOI 10.1016/j.phrs.2020.104726
   Wu Y, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035508
   Xiong SQ, 2015, CELL REP, V12, P1391, DOI 10.1016/j.celrep.2015.07.047
   Xue BZ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0045990
   Xue H, 2006, VASC PHARMACOL, V44, P434, DOI 10.1016/j.vph.2006.02.005
   Yan DH, 2013, EUR J IMMUNOL, V43, P2943, DOI 10.1002/eji.201343472
   Yang CR, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0171442
   Youssef M, 2019, NEUROSCIENCE, V397, P18, DOI 10.1016/j.neuroscience.2018.11.030
   Zhang JY, 2017, PROSTAG LEUKOTR ESS, V123, P25, DOI 10.1016/j.plefa.2017.07.001
   Zhang JW, 2016, AGEING RES REV, V25, P55, DOI 10.1016/j.arr.2015.11.006
   Zhang SY, 2020, AGING DIS, V11, P494, DOI 10.14336/AD.2019.0721
   Zhao Y, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-1194-1
   Zheng Q, 2019, FRONT CELL DEV BIOL, V7, DOI 10.3389/fcell.2019.00274
   Zhou TY, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19020417
   Zuo L, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20184472
NR 168
TC 1
Z9 1
U1 2
U2 15
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD MAY 29
PY 2024
VL 64
IS 14
BP 4457
EP 4476
DI 10.1080/10408398.2022.2142196
EA OCT 2022
PG 20
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA QO3A7
UT WOS:000878903000001
PM 36330807
DA 2025-06-11
ER

PT J
AU Song, GH
   Li, M
   Sang, H
   Zhang, LY
   Li, XH
   Yao, ST
   Yu, Y
   Zong, CL
   Xue, YH
   Qin, SC
AF Song, Guohua
   Li, Min
   Sang, Hui
   Zhang, Liying
   Li, Xiuhong
   Yao, Shutong
   Yu, Yang
   Zong, Chuanlong
   Xue, Yazhuo
   Qin, Shucun
TI Hydrogen-rich water decreases serum LDL-cholesterol levels and improves
   HDL function in patients with potential metabolic syndrome
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE apolipoprotein B; antioxidative property; low density lipoprotein; high
   density lipoprotein
ID LOW-DENSITY-LIPOPROTEIN; TRANSFER PROTEIN; MESSENGER-RNA; INFLAMMATION;
   DYSLIPIDEMIA; ASSOCIATION; RECEPTOR; GENE
AB We have found that hydrogen (dihydrogen; H-2) has beneficial lipid-lowering effects in high-fat diet-fed Syrian golden hamsters. The objective of this study was to characterize the effects of H-2-rich water (0.9-1.0 l/day) on the content, composition, and biological activities of serum lipoproteins on 20 patients with potential metabolic syndrome. Serum analysis showed that consumption of H-2-rich water for 10 weeks resulted in decreased serum total-cholesterol (TC) and LDL-cholesterol (LDL-C) levels. Western blot analysis revealed a marked decrease of apolipoprotein (apo)B100 and apoE in serum. In addition, we found H-2 significantly improved HDL functionality assessed in four independent ways, namely, i) protection against LDL oxidation, ii) inhibition of tumor necrosis factor (TNF)-alpha-induced monocyte adhesion to endothelial cells, iii) stimulation of cholesterol efflux from macrophage foam cells, and iv) protection of endothelial cells from TNF-alpha-induced apoptosis. Further, we found consumption of H-2-rich water resulted in an increase in antioxidant enzyme superoxide dismutase and a decrease in thiobarbituric acid-reactive substances in whole serum and LDL. In conclusion, supplementation with H-2-rich water seems to decrease serum LDL-C and apoB levels, improve dyslipidemia-injured HDL functions, and reduce oxidative stress, and it may have a beneficial role in prevention of potential metabolic syndrome.
C1 [Song, Guohua; Yu, Yang; Zong, Chuanlong; Qin, Shucun] Shandong Univ, Key Lab Atherosclerosis, Jinan, Shandong, Peoples R China.
   [Song, Guohua; Yu, Yang; Zong, Chuanlong; Qin, Shucun] Taishan Med Univ, Inst Atherosclerosis, Tai An, Shandong, Peoples R China.
   [Li, Min; Zhang, Liying; Xue, Yazhuo] Taishan Med Univ, Inst Nursing, Tai An, Shandong, Peoples R China.
   [Sang, Hui; Yao, Shutong] Taishan Med Univ, Inst Basic Med, Tai An, Shandong, Peoples R China.
   [Li, Xiuhong] Taishan Mental Dis Hosp, Tai An, Shandong, Peoples R China.
C3 Shandong University; Taishan University; Shandong First Medical
   University & Shandong Academy of Medical Sciences; Shandong First
   Medical University & Shandong Academy of Medical Sciences; Taishan
   University; Taishan University; Shandong First Medical University &
   Shandong Academy of Medical Sciences
RP Xue, YH (corresponding author), Taishan Med Univ, Inst Nursing, Tai An, Shandong, Peoples R China.
EM yzxue@tsmc.edu.cn; shucunqin@hotmail.com
RI Li, Xiuhong/KHT-5321-2024
FU Taishan Scholars Foundation of Shandong Province [zd056, zd057]; special
   research funding of Taishan Medical University; National Natural Science
   Foundation of China [81200216]; Promotive Research Fund for Excellent
   Young and Middle-aged Scientists of Shandong Province [BS2012YY034]
FX This work was supported by the Taishan Scholars Foundation of Shandong
   Province (zd056, zd057); special research funding of Taishan Medical
   University (2008); National Natural Science Foundation of China
   (81200216), and Promotive Research Fund for Excellent Young and
   Middle-aged Scientists of Shandong Province (BS2012YY034).
CR Amitani H, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0053913
   BASU SK, 1981, P NATL ACAD SCI-BIOL, V78, P7545, DOI 10.1073/pnas.78.12.7545
   Cifuentes-Goches Juan C, 2012, Rev Med Inst Mex Seguro Soc, V50, P301
   Esteve E, 2005, CLIN NUTR, V24, P16, DOI 10.1016/j.clnu.2004.08.004
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   GEURIAN K, 1992, ANN PHARMACOTHER, V26, P1109, DOI 10.1177/106002809202600913
   Gharib B, 2001, CR ACAD SCI III-VIE, V324, P719, DOI 10.1016/S0764-4469(01)01350-6
   GORDON T, 1977, AM J MED, V62, P707, DOI 10.1016/0002-9343(77)90874-9
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Holvoet P, 2008, JAMA-J AM MED ASSOC, V299, P2287, DOI 10.1001/jama.299.19.2287
   Itahara T, 2000, J Atheroscler Thromb, V7, P152
   JIANG XC, 1993, J BIOL CHEM, V268, P27406
   Jiang XC, 1999, J CLIN INVEST, V103, P907, DOI 10.1172/JCI5578
   Kajiyama S, 2008, NUTR RES, V28, P137, DOI 10.1016/j.nutres.2008.01.008
   Khovidhunkit W, 2004, J LIPID RES, V45, P1169, DOI 10.1194/jlr.R300019-JLR200
   Kolovou G, 2008, CURR PHARM DESIGN, V14, P338, DOI 10.2174/138161208783497769
   Kontush A, 2006, PHARMACOL REV, V58, P342, DOI 10.1124/pr.58.3.1
   MA PTS, 1986, P NATL ACAD SCI USA, V83, P8370, DOI 10.1073/pnas.83.21.8370
   McCrohon JA, 1999, CIRCULATION, V99, P2317, DOI 10.1161/01.CIR.99.17.2317
   MORI M, 1990, J CELL SCI, V95, P481
   Ohsawa I, 2007, NAT MED, V13, P688, DOI 10.1038/nm1577
   Ohsawa I, 2008, BIOCHEM BIOPH RES CO, V377, P1195, DOI 10.1016/j.bbrc.2008.10.156
   Rikitake Y, 1998, ATHEROSCLEROSIS, V136, P51, DOI 10.1016/S0021-9150(97)00186-X
   Smith JD, 1996, J BIOL CHEM, V271, P30647, DOI 10.1074/jbc.271.48.30647
   Song GH, 2012, ATHEROSCLEROSIS, V221, P55, DOI 10.1016/j.atherosclerosis.2011.11.043
   Suzuki Y, 2009, FEBS LETT, V583, P2157, DOI 10.1016/j.febslet.2009.05.052
   Tamada M, 2010, METABOLISM, V59, P653, DOI 10.1016/j.metabol.2009.09.009
   Van Lenten BJ, 2001, TRENDS CARDIOVAS MED, V11, P155, DOI 10.1016/S1050-1738(01)00095-0
   Zong CL, 2012, METABOLISM, V61, P794, DOI 10.1016/j.metabol.2011.10.014
NR 30
TC 105
Z9 117
U1 2
U2 40
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD JUL
PY 2013
VL 54
IS 7
BP 1884
EP 1893
DI 10.1194/jlr.M036640
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 162AA
UT WOS:000320235200016
PM 23610159
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Teragawa, H
   Morita, K
   Shishido, H
   Otsuka, N
   Hirokawa, Y
   Chayama, K
   Tamaki, N
   Kihara, Y
AF Teragawa, Hiroki
   Morita, Koichi
   Shishido, Hiroki
   Otsuka, Nobuaki
   Hirokawa, Yutaka
   Chayama, Kazuaki
   Tamaki, Nagara
   Kihara, Yasuki
TI Impaired myocardial blood flow reserve in subjects with metabolic
   syndrome analyzed using positron emission tomography and N-13 labeled
   ammonia
SO EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
LA English
DT Article
DE Metabolic syndrome; Abnormal coronary microvascular response; Insulin
   resistance
ID NITRIC-OXIDE SYNTHASE; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; PROGNOSTIC VALUE; CORONARY; RISK;
   HYPERTENSION; MORTALITY
AB Coronary vasomotor response might be impaired in metabolic syndrome (MS); however, the precise abnormality has not been elucidated. The aim of this study was to assess coronary-vasomotor response in MS subjects using N-13 labeled ammonia and positron emission tomography.
   Myocardial blood flow (MBF) was measured at rest and during adenosine infusion in MS subjects (n = 13, MS group) with no definite evidence of heart disease and in subjects without MS (n = 14, non-MS group). Coronary vascular resistance (CVR) was calculated by dividing the mean aortic blood pressure by MBF. Myocardial blood flow reserve (MFR) was calculated as the ratio of the MBF during adenosine infusion to that during rest. Blood chemical parameters were measured to evaluate their relationship with MFR. During adenosine infusion, MBF was lower (p = 0.0085) and CVR higher (p = 0.0128) in the MS group than in the non-MS group and MFR was significantly lower in the MS group than in the non-MS group (2.13 +/- 0.99 vs. 3.38 +/- 0.95, p = 0.0027). Multivariate analysis demonstrated that the homeostasis model assessment-insulin resistance (p < 0.05) and the presence of hypertension (p < 0.05) were independent determinants of MFR.
   The results indicate that MFR was impaired in MS subjects, suggesting that an abnormal coronary microvascular response occurred in these subjects. This abnormality may have been partially due to insulin resistance and hypertension.
C1 [Teragawa, Hiroki; Kihara, Yasuki] Hiroshima Univ, Grad Sch Biomed Sci, Dept Cardiovasc Med, Minami Ku, Hiroshima 7348551, Japan.
   [Morita, Koichi; Tamaki, Nagara] Hokkaido Univ, Grad Sch Med, Dept Nucl Med, Sapporo, Hokkaido, Japan.
   [Shishido, Hiroki; Otsuka, Nobuaki; Hirokawa, Yutaka] Hiroshima Heiwa Clin, Hiroshima, Japan.
   [Chayama, Kazuaki] Hiroshima Univ, Grad Sch Biomed Sci, Dept Mol Sci & Med, Hiroshima 7348551, Japan.
C3 Hiroshima University; Hokkaido University; Hiroshima University
RP Teragawa, H (corresponding author), Hiroshima Univ, Grad Sch Biomed Sci, Dept Cardiovasc Med, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan.
EM hteraga@hiroshima-u.ac.jp
RI Teragawa, Hiroki/AAJ-5116-2020; Chayama, Kazuaki/B-2493-2016
OI Chayama, Kazuaki/0000-0002-5530-5341
CR Buus NH, 2001, CIRCULATION, V104, P2305, DOI 10.1161/hc4401.098293
   Chen H, 2003, J BIOL CHEM, V278, P45021, DOI 10.1074/jbc.M307878200
   de Jongh RT, 2004, CIRCULATION, V109, P2529, DOI 10.1161/01.CIR.0000129772.26647.6F
   DEVEREUX RB, 1984, J AM COLL CARDIOL, V4, P1222, DOI 10.1016/S0735-1097(84)80141-2
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Herzog BA, 2009, J AM COLL CARDIOL, V54, P150, DOI 10.1016/j.jacc.2009.02.069
   Higashi Y, 2002, NEW ENGL J MED, V346, P1954, DOI 10.1056/NEJMoa013591
   Higashi Y, 2001, J AM COLL CARDIOL, V37, P863, DOI 10.1016/S0735-1097(00)01177-3
   Hu G, 2004, ARCH INTERN MED, V164, P1066, DOI 10.1001/archinte.164.10.1066
   HUTCHINS GD, 1990, J AM COLL CARDIOL, V15, P1032, DOI 10.1016/0735-1097(90)90237-J
   Kawashima S, 2004, ARTERIOSCL THROM VAS, V24, P998, DOI 10.1161/01.ATV.0000125114.88079.96
   Koepfli P, 2004, J NUCL MED, V45, P537
   Kozakova M, 1997, HYPERTENSION, V29, P551, DOI 10.1161/01.HYP.29.2.551
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Liu PY, 2007, J AM COLL CARDIOL, V49, P1619, DOI 10.1016/j.jacc.2006.12.043
   Lteif AA, 2005, CIRCULATION, V112, P32, DOI 10.1161/CIRCULATIONAHA.104.520130
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   McNeill AM, 2005, DIABETES CARE, V28, P385, DOI 10.2337/diacare.28.2.385
   Moller DE, 2005, ANNU REV MED, V56, P45, DOI 10.1146/annurev.med.56.082103.104751
   Montagnani M, 2001, J BIOL CHEM, V276, P30392, DOI 10.1074/jbc.M103702200
   Namdar M, 2006, J AM COLL CARDIOL, V47, P405, DOI 10.1016/j.jacc.2005.08.064
   Naya M, 2007, J AM COLL CARDIOL, V50, P1144, DOI 10.1016/j.jacc.2007.06.013
   Naya M, 2007, CIRC J, V71, P348, DOI 10.1253/circj.71.348
   Perticone F, 2001, DIABETES, V50, P159, DOI 10.2337/diabetes.50.1.159
   Pirat B, 2008, ATHEROSCLEROSIS, V201, P112, DOI 10.1016/j.atherosclerosis.2008.02.016
   Quiñones MJ, 2004, ANN INTERN MED, V140, P700, DOI 10.7326/0003-4819-140-9-200405040-00009
   Schillaci G, 2004, J AM COLL CARDIOL, V43, P1817, DOI 10.1016/j.jacc.2003.12.049
   Schindler TH, 2006, J AM COLL CARDIOL, V47, P1188, DOI 10.1016/j.jacc.2005.10.062
   Schindler TH, 2007, J NUCL CARDIOL, V14, P589, DOI 10.1016/j.nuclcard.2007.05.006
   Solymoss BC, 2004, AM J CARDIOL, V93, P159, DOI 10.1016/j.amjcard.2003.09.032
   Steinberg HO, 1996, J CLIN INVEST, V97, P2601, DOI 10.1172/JCI118709
   Takeuchi H, 2005, HYPERTENS RES, V28, P203, DOI 10.1291/hypres.28.203
   Tawakol A, 2002, J AM COLL CARDIOL, V40, P1051, DOI 10.1016/S0735-1097(02)02069-7
   Tsukamoto T, 2006, EUR J NUCL MED MOL I, V33, P1150, DOI 10.1007/s00259-006-0082-x
   Yokoyama I, 1998, DIABETES, V47, P119, DOI 10.2337/diabetes.47.1.119
   Yokoyama I, 1996, CIRCULATION, V94, P3232, DOI 10.1161/01.CIR.94.12.3232
   Yokoyama I, 2001, J NUCL CARDIOL, V8, P445, DOI 10.1067/mnc.2001.115517
   Yoshizumi T, 1999, RADIOLOGY, V211, P283, DOI 10.1148/radiology.211.1.r99ap15283
NR 39
TC 12
Z9 15
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1619-7070
EI 1619-7089
J9 EUR J NUCL MED MOL I
JI Eur. J. Nucl. Med. Mol. Imaging
PD FEB
PY 2010
VL 37
IS 2
BP 368
EP 376
DI 10.1007/s00259-009-1307-6
PG 9
WC Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Radiology, Nuclear Medicine & Medical Imaging
GA 552MC
UT WOS:000274293900019
PM 19915835
DA 2025-06-11
ER

PT J
AU Grootaert, MOJ
AF Grootaert, Mandy O. J.
TI Cell senescence in cardiometabolic diseases
SO NPJ AGING
LA English
DT Review
ID SMOOTH-MUSCLE-CELLS; TUBULAR EPITHELIAL-CELLS; SECRETORY PHENOTYPE;
   OXIDATIVE STRESS; DNA-DAMAGE; LIFE-SPAN; MITOCHONDRIAL DYSFUNCTION;
   REPLICATIVE SENESCENCE; PREMATURE SENESCENCE; CARDIOVASCULAR-DISEASE
AB Cellular senescence has been implicated in many age-related pathologies including atherosclerosis, heart failure, age-related cardiac remodeling, diabetic cardiomyopathy and the metabolic syndrome. Here, we will review the characteristics of senescent cells and their endogenous regulators, and summarize the metabolic stressors that induce cell senescence. We will discuss the evidence of cell senescence in the onset and progression of several cardiometabolic diseases and the therapeutic potential of anti-senescence therapies.
C1 [Grootaert, Mandy O. J.] UCLouvain, Endocrinol Diabet & Nutr, Brussels, Belgium.
   [Grootaert, Mandy O. J.] Katholieke Univ Leuven, Ctr Mol & Vasc Biol, Dept Cardiovasc Sci, Leuven, Belgium.
C3 Universite Catholique Louvain; KU Leuven
RP Grootaert, MOJ (corresponding author), UCLouvain, Endocrinol Diabet & Nutr, Brussels, Belgium.; Grootaert, MOJ (corresponding author), Katholieke Univ Leuven, Ctr Mol & Vasc Biol, Dept Cardiovasc Sci, Leuven, Belgium.
EM mandy.grootaert@uclouvain.be
FU IREC (Institut de Recherche Experimentale et Clinique) institute at
   UCLouvain
FX I would like to express my gratitude to the IREC (Institut de Recherche
   Experimentale et Clinique) institute at UCLouvain for their financial
   support for the publication of this article. Figures were created in
   Microsoft PowerPoint using images from Servier Medical Art licensed
   under CC BY 4.0.
CR Abdelgawad IY, 2023, FRONT AGING-LAUSANNE, V4, DOI 10.3389/fragi.2023.1170434
   Acosta JC, 2013, NAT CELL BIOL, V15, P978, DOI 10.1038/ncb2784
   Aguayo-Mazzucato C, 2019, CELL METAB, V30, P129, DOI 10.1016/j.cmet.2019.05.006
   Aman Y, 2021, NATURE AGING, V1, P634, DOI 10.1038/s43587-021-00098-4
   Amor C, 2024, NATURE AGING, V4, DOI 10.1038/s43587-023-00560-5
   Amor C, 2020, NATURE, V583, P127, DOI 10.1038/s41586-020-2403-9
   Anderson R, 2019, EMBO J, V38, DOI 10.15252/embj.2018100492
   Baraibar MA, 2016, AGING-US, V8, P3375, DOI 10.18632/aging.101126
   Basisty N, 2020, PLOS BIOL, V18, DOI 10.1371/journal.pbio.3000599
   Battault S, 2020, ARCH CARDIOVASC DIS, V113, P736, DOI 10.1016/j.acvd.2020.06.006
   Beck J, 2020, CARCINOGENESIS, V41, P1017, DOI 10.1093/carcin/bgaa071
   Bertelli PM, 2022, FRONT PHYSIOL, V13, DOI 10.3389/fphys.2022.929118
   BITTLES AH, 1984, BIOSCIENCE REP, V4, P751, DOI 10.1007/BF01128816
   Bitto A, 2016, ELIFE, V5, DOI 10.7554/eLife.16351
   Blazer S, 2002, BIOCHEM BIOPH RES CO, V296, P93, DOI 10.1016/S0006-291X(02)00818-5
   Boccardi V, 2013, FASEB J, V27, P3879, DOI 10.1096/fj.13-232066
   Borghesan M, 2019, CELL REP, V27, P3956, DOI 10.1016/j.celrep.2019.05.095
   Born E, 2023, CIRCULATION, V147, P650, DOI 10.1161/CIRCULATIONAHA.122.058794
   Browder KC, 2022, NATURE AGING, V2, P243, DOI 10.1038/s43587-022-00183-2
   Burton DGA, 2018, AGEING RES REV, V43, P17, DOI 10.1016/j.arr.2018.02.001
   Camacho-Pereira J, 2016, CELL METAB, V23, P1127, DOI 10.1016/j.cmet.2016.05.006
   Cantó C, 2012, CELL METAB, V15, P838, DOI 10.1016/j.cmet.2012.04.022
   Cao K, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3002346
   Cardus A, 2013, CARDIOVASC RES, V97, P571, DOI 10.1093/cvr/cvs352
   Cassidy LD, 2022, MOL ONCOL, V16, P3259, DOI 10.1002/1878-0261.13269
   Castellano JM, 2019, GERONTOLOGY, V65, P84, DOI 10.1159/000492573
   Chaib S, 2022, NAT MED, V28, P1556, DOI 10.1038/s41591-022-01923-y
   Chen JH, 2007, NUCLEIC ACIDS RES, V35, P7417, DOI 10.1093/nar/gkm681
   Childs BG, 2016, SCIENCE, V354, P472, DOI 10.1126/science.aaf6659
   Chong CR, 2017, CARDIOVASC RES, V113, P422, DOI 10.1093/cvr/cvx018
   Colavitti R, 2005, IUBMB LIFE, V57, P277, DOI 10.1080/15216540500091890
   Correia-Melo C, 2016, EMBO J, V35, P724, DOI 10.15252/embj.201592862
   Correia-Melo C, 2015, BBA-BIOENERGETICS, V1847, P1373, DOI 10.1016/j.bbabio.2015.05.017
   Covarrubias AJ, 2020, NAT METAB, V2, DOI 10.1038/s42255-020-00305-3
   Csiszar A, 2012, J GERONTOL A-BIOL, V67, P811, DOI 10.1093/gerona/glr228
   Csiszar A, 2009, AM J PHYSIOL-HEART C, V297, pH13, DOI 10.1152/ajpheart.00368.2009
   Cui Xing-Jun, 2020, Aging Med (Milton), V3, P178, DOI 10.1002/agm2.12106
   Cunningham JT, 2007, NATURE, V450, P736, DOI 10.1038/nature06322
   d'Aiello A, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24108643
   Dagher O, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.741542
   Dai DF, 2012, CIRC RES, V110, P1109, DOI 10.1161/CIRCRESAHA.111.246140
   Demidenko ZN, 2009, CELL CYCLE, V8, P1888, DOI 10.4161/cc.8.12.8606
   DIMRI GP, 1995, P NATL ACAD SCI USA, V92, P9363, DOI 10.1073/pnas.92.20.9363
   Dookun E, 2022, CARDIOVASC DRUG THER, V36, P187, DOI 10.1007/s10557-020-07075-w
   Du LG, 2019, DRUG DES DEV THER, V13, P747, DOI 10.2147/DDDT.S179894
   Fafián-Labora J, 2019, CELL DEATH DIS, V10, DOI 10.1038/s41419-019-1550-0
   Farr JN, 2017, NAT MED, V23, P1072, DOI 10.1038/nm.4385
   Fernandez-Rebollo E, 2020, STEM CELL REP, V14, P201, DOI 10.1016/j.stemcr.2019.12.012
   Flor AC, 2017, CELL DEATH DISCOV, V3, DOI 10.1038/cddiscovery.2017.75
   Franceschi C, 2014, J GERONTOL A-BIOL, V69, pS4, DOI 10.1093/gerona/glu057
   Gan L, 2021, SIGNAL TRANSDUCT TAR, V6, DOI 10.1038/s41392-021-00625-0
   Gardner SE, 2015, ARTERIOSCL THROM VAS, V35, P1963, DOI 10.1161/ATVBAHA.115.305896
   Garrido AM, 2022, CARDIOVASC RES, V118, P1713, DOI 10.1093/cvr/cvab208
   Gasek NS, 2021, NATURE AGING, V1, P870, DOI 10.1038/s43587-021-00121-8
   Gaziano L, 2021, ESC HEART FAIL, V8, P4893, DOI 10.1002/ehf2.13429
   Gevaert AB, 2017, CIRC-HEART FAIL, V10, DOI 10.1161/CIRCHEARTFAILURE.116.003806
   González-Gualda E, 2021, FEBS J, V288, P56, DOI 10.1111/febs.15570
   Grootaert MOJ, 2022, NAT REV CARDIOL, V19, P668, DOI 10.1038/s41569-022-00685-x
   Grootaert MOJ, 2021, CIRC RES, V128, P474, DOI 10.1161/CIRCRESAHA.120.318353
   Grootaert MOJ, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/7687083
   Grootaert MOJ, 2015, AUTOPHAGY, V11, P2014, DOI 10.1080/15548627.2015.1096485
   Grosse L, 2020, CELL METAB, V32, P87, DOI 10.1016/j.cmet.2020.05.002
   Gustafson CE, 2020, J ALLERGY CLIN IMMUN, V145, P1309, DOI 10.1016/j.jaci.2020.03.017
   Hall BM, 2017, AGING-US, V9, P1867, DOI 10.18632/aging.101268
   Hardie DG, 2012, NAT REV MOL CELL BIO, V13, P251, DOI 10.1038/nrm3311
   Harrison DE, 2009, NATURE, V460, P392, DOI 10.1038/nature08221
   Hauck AK, 2016, J LIPID RES, V57, P1976, DOI 10.1194/jlr.R066597
   Hayashi T, 2006, P NATL ACAD SCI USA, V103, P17018, DOI 10.1073/pnas.0607873103
   He YH, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-15838-0
   Hernández-Silva D, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms231810468
   Herranz N, 2015, NAT CELL BIOL, V17, P1205, DOI 10.1038/ncb3225
   Hickson LJ, 2019, EBIOMEDICINE, V47, P446, DOI 10.1016/j.ebiom.2019.08.069
   Honda S, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-94097-5
   Hyyti OM, 2010, AM J PHYSIOL-HEART C, V299, pH868, DOI 10.1152/ajpheart.00931.2009
   Imai S, 2016, NPJ AGING MECH DIS, V2, DOI 10.1038/npjamd.2016.17
   Imai S, 2014, TRENDS CELL BIOL, V24, P464, DOI 10.1016/j.tcb.2014.04.002
   Islam MT, 2023, AGING CELL, V22, DOI 10.1111/acel.13767
   James EL, 2015, J PROTEOME RES, V14, P1854, DOI 10.1021/pr501221g
   Jin JH, 2013, CELL PHYSIOL BIOCHEM, V31, P718, DOI 10.1159/000350090
   Kaefer A, 2014, CANCER CHEMOTH PHARM, V74, P593, DOI 10.1007/s00280-014-2530-9
   Kane AE, 2018, CIRC RES, V123, P868, DOI 10.1161/CIRCRESAHA.118.312498
   Kao CL, 2010, J ATHEROSCLER THROMB, V17, P970, DOI 10.5551/jat.4333
   Karnewar S, 2024, JCI INSIGHT, V9, DOI 10.1172/jci.insight.173863
   Kim D, 2022, GEROSCIENCE, V44, P2701, DOI 10.1007/s11357-022-00645-w
   Kim KM, 2017, GENE DEV, V31, P1529, DOI 10.1101/gad.302570.117
   Korolchuk VI, 2017, EBIOMEDICINE, V21, P7, DOI 10.1016/j.ebiom.2017.03.020
   Kulkarni AS, 2020, CELL METAB, V32, P15, DOI 10.1016/j.cmet.2020.04.001
   Laberge RM, 2015, NAT CELL BIOL, V17, P1049, DOI 10.1038/ncb3195
   Le Pelletier L, 2021, ELIFE, V10, DOI [10.7554/eLife.62635, 10.7554/eLife.62635.sa1, 10.7554/eLife.62635.sa2]
   Lener B, 2009, BIOCHEM J, V423, P363, DOI 10.1042/BJ20090666
   Leon BM, 2015, WORLD J DIABETES, V6, P1246, DOI 10.4239/wjd.v6.i13.1246
   Lesnefsky EJ, 2016, CIRC RES, V118, P1593, DOI 10.1161/CIRCRESAHA.116.307505
   Lewis-McDougall FC, 2019, AGING CELL, V18, DOI 10.1111/acel.12931
   Li YP, 2018, AM J PHYSIOL-HEART C, V315, pH571, DOI 10.1152/ajpheart.00038.2018
   Liu J, 2015, AM J PHYSIOL-CELL PH, V308, pC621, DOI 10.1152/ajpcell.00096.2014
   Liu J, 2014, CELL SIGNAL, V26, P110, DOI 10.1016/j.cellsig.2013.10.002
   Mahmoudi M, 2008, CIRC RES, V103, P717, DOI 10.1161/CIRCRESAHA.108.182899
   Mahoney SA, 2024, AGING CELL, V23, DOI 10.1111/acel.14060
   Marino F, 2022, DIABETES, V71, P1081, DOI 10.2337/db21-0536
   Martin-Montalvo A, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3192
   Martini H, 2023, FEBS J, V290, P1186, DOI 10.1111/febs.16361
   Matthews C, 2006, CIRC RES, V99, P156, DOI 10.1161/01.RES.0000233315.38086.bc
   McHugh D, 2018, J CELL BIOL, V217, P65, DOI 10.1083/jcb.201708092
   McNeill AM, 2005, DIABETES CARE, V28, P385, DOI 10.2337/diacare.28.2.385
   Mdaki KS, 2018, FASEB J, V32
   Meyer K, 2016, J AM COLL CARDIOL, V67, P2018, DOI 10.1016/j.jacc.2016.02.047
   Moiseeva O, 2013, AGING CELL, V12, P489, DOI 10.1111/acel.12075
   Mondal AM, 2013, J CLIN INVEST, V123, P5247, DOI 10.1172/JCI70355
   Muñoz DP, 2019, JCI INSIGHT, V4, DOI 10.1172/jci.insight.124716
   Narasimhan A, 2021, ENDOCRINOLOGY, V162, DOI 10.1210/endocr/bqab136
   Narita M, 2011, SCIENCE, V332, P966, DOI 10.1126/science.1205407
   Neff F, 2013, J CLIN INVEST, V123, P3272, DOI 10.1172/JCI67674
   Nelson G, 2012, AGING CELL, V11, P345, DOI 10.1111/j.1474-9726.2012.00795.x
   Ocampo A, 2016, CELL, V167, P1719, DOI 10.1016/j.cell.2016.11.052
   Osorio JM, 2023, BBA-MOL BASIS DIS, V1869, DOI 10.1016/j.bbadis.2023.166642
   Ota H, 2010, ARTERIOSCL THROM VAS, V30, P2205, DOI 10.1161/ATVBAHA.110.210500
   Paez-Ribes M, 2019, EMBO MOL MED, V11, DOI 10.15252/emmm.201810234
   Pallauf K, 2016, CURR MED CHEM, V23, P4639, DOI 10.2174/0929867323666161024151233
   Palmer AK, 2019, AGING CELL, V18, DOI 10.1111/acel.12950
   Paramos-de-Carvalho D, 2021, ELIFE, V10, DOI 10.7554/eLife.72449
   Passos JF, 2010, MOL SYST BIOL, V6, DOI 10.1038/msb.2010.5
   Pereira BI, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-10335-5
   Quijano C, 2012, CELL CYCLE, V11, P1383, DOI 10.4161/cc.19800
   Quintás-Cardama A, 2009, CANCER-AM CANCER SOC, V115, P3935, DOI 10.1002/cncr.24432
   Ralapanawa U, 2021, J EPIDEMIOL GLOB HEA, V11, P169, DOI 10.2991/jegh.k.201217.001
   Rena G, 2018, CIRCULATION, V137, P422, DOI 10.1161/CIRCULATIONAHA.117.031735
   Rodgers JL, 2019, J CARDIOVASC DEV DIS, V6, DOI 10.3390/jcdd6020019
   Rodier F, 2011, J CELL BIOL, V192, P547, DOI 10.1083/jcb.201009094
   Roos CM, 2016, AGING CELL, V15, P973, DOI 10.1111/acel.12458
   Rota M, 2006, CIRC RES, V99, P42, DOI 10.1161/01.RES.0000231289.63468.08
   Roupakia E, 2021, MECH AGEING DEV, V194, DOI 10.1016/j.mad.2021.111432
   Saretzki G, 2003, AGING CELL, V2, P141, DOI 10.1046/j.1474-9728.2003.00040.x
   Savarese G, 2022, CARDIOVASC RES, V118, P3272, DOI 10.1093/cvr/cvac013
   Saxton RA, 2017, CELL, V168, P960, DOI [10.1016/j.cell.2017.02.004, 10.1016/j.cell.2017.03.035]
   Schiattarella GG, 2022, NAT CARDIOVASC RES, V1, P211, DOI 10.1038/s44161-022-00032-w
   Schloesser D, 2022, J CELL BIOL, V222, DOI 10.1083/jcb.202207097
   Shosha E, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19041215
   Silva E., 2021, PREPRINT, DOI [10.21203/rs.3.rs-624229/v1, DOI 10.21203/RS.3.RS-624229/V1]
   Simmonds SJ, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9010242
   Sone H, 2005, DIABETOLOGIA, V48, P58, DOI 10.1007/s00125-004-1605-2
   Stojanovic SD, 2020, EUR HEART J, V41, P2983, DOI 10.1093/eurheartj/ehz919
   Suda M, 2021, NATURE AGING, V1, P1117, DOI 10.1038/s43587-021-00151-2
   Sung JY, 2018, EXP GERONTOL, V109, P51, DOI 10.1016/j.exger.2017.08.001
   Tai HR, 2017, AUTOPHAGY, V13, P99, DOI 10.1080/15548627.2016.1247143
   Takasugi M, 2018, AGING CELL, V17, DOI 10.1111/acel.12734
   Tarrago MG, 2018, CELL METAB, V27, P1081, DOI 10.1016/j.cmet.2018.03.016
   Trammell SAJ, 2016, SCI REP-UK, V6, DOI 10.1038/srep26933
   Trayssac M, 2018, J CLIN INVEST, V128, P2702, DOI 10.1172/JCI97949
   Velarde MC, 2012, AGING-US, V4, P3, DOI 10.18632/aging.100423
   Victorelli S, 2019, EMBO J, V38, DOI 10.15252/embj.2019101982
   Walaszczyk A, 2019, AGING CELL, V18, DOI 10.1111/acel.12945
   Wang BS, 2024, NAT REV MOL CELL BIO, V25, P958, DOI 10.1038/s41580-024-00727-x
   Wang LF, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms242116008
   Wang R, 2017, AGING CELL, V16, P564, DOI 10.1111/acel.12587
   Wang XQ, 2024, NAT COMMUN, V15, DOI 10.1038/s41467-024-45582-8
   Weichhart T, 2018, GERONTOLOGY, V64, P127, DOI 10.1159/000484629
   Weyemi U, 2012, ONCOGENE, V31, P1117, DOI 10.1038/onc.2011.327
   Wiley CD, 2021, NAT METAB, V3, P1290, DOI 10.1038/s42255-021-00483-8
   Wiley CD, 2016, CELL METAB, V23, P303, DOI 10.1016/j.cmet.2015.11.011
   Wu RC, 2024, NATURE AGING, V4, P464, DOI 10.1038/s43587-024-00597-0
   Xia L, 2008, BRIT J PHARMACOL, V155, P387, DOI 10.1038/bjp.2008.272
   Xie SY, 2023, SIGNAL TRANSDUCT TAR, V8, DOI 10.1038/s41392-023-01378-8
   Xiong XW, 2016, J ENDOCRINOL, V231, P159, DOI 10.1530/JOE-16-0317
   Xu M, 2015, P NATL ACAD SCI USA, V112, pE6301, DOI 10.1073/pnas.1515386112
   Xu ZS, 2009, HEMATOL REP, V1, P17, DOI 10.4081/hr.2009.e4
   Yoshida S, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-16347-w
   Yoshino J, 2011, CELL METAB, V14, P528, DOI 10.1016/j.cmet.2011.08.014
   Young ARJ, 2009, GENE DEV, V23, P798, DOI 10.1101/gad.519709
   Zhang L, 2023, FEBS J, V290, P1362, DOI 10.1111/febs.16350
   Zhang YQ, 2017, REDOX BIOL, V11, P30, DOI 10.1016/j.redox.2016.10.014
   Zhu FL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0074535
   Zhu Y, 2015, AGING CELL, V14, P644, DOI 10.1111/acel.12344
   Ziegler DV, 2015, AGING CELL, V14, P1, DOI 10.1111/acel.12287
   Zwerschke W, 2003, BIOCHEM J, V376, P403, DOI 10.1042/BJ20030816
NR 174
TC 3
Z9 3
U1 1
U2 1
PU NATURE PUBL GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2731-6068
J9 NPJ AGING
JI npj Aging
PD OCT 21
PY 2024
VL 10
IS 1
AR 46
DI 10.1038/s41514-024-00170-4
PG 14
WC Geriatrics & Gerontology
WE Emerging Sources Citation Index (ESCI)
SC Geriatrics & Gerontology
GA J5U9Y
UT WOS:001337727200001
PM 39433786
OA Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Vekic, DA
   Frew, J
   Cains, GD
AF Vekic, Dunja Ana
   Frew, John
   Cains, Geoffrey David
TI Hidradenitis suppurativa, a review of pathogenesis, associations and
   management. Part 1
SO AUSTRALASIAN JOURNAL OF DERMATOLOGY
LA English
DT Review
DE autoinflammation; hidradenitis suppurativa
ID PYODERMA-GANGRENOSUM; METABOLIC SYNDROME; BACTERIAL BIOFILM;
   MECHANICAL-STRESS; DOWN-SYNDROME; ACNE INVERSA; PREVALENCE; SKIN;
   DISEASE; LESIONS
AB Hidradenitis suppurativa is a chronic, painful, autoinflammatory condition resulting in nodules, abscesses and sinus tracts. We present an evidence-based review providing new understanding of the pathogenesis of hidradenitis suppurativa and associated comorbidities. By the nature of their speciality, dermatologists are uniquely positioned to investigate and treat patients with this condition. Data collected from a subspecialty hidradenitis suppurativa clinic (N = 106) and experiences thereof are discussed in this review.
C1 [Vekic, Dunja Ana; Cains, Geoffrey David] Ingham Inst Appl Med Res, Sydney, NSW, Australia.
   [Vekic, Dunja Ana; Frew, John] Liverpool Hosp, Dept Dermatol, Sydney, NSW, Australia.
   [Vekic, Dunja Ana; Frew, John; Cains, Geoffrey David] Univ New South Wales, Sydney, NSW, Australia.
C3 Ingham Institute for Applied Medical Research; Liverpool Hospital;
   University of New South Wales Sydney
RP Vekic, DA (corresponding author), Ingham Inst Appl Med Res, Dermatol Res Grp, 1 Campbell St, Liverpool, NSW 2170, Australia.
EM dunja.vekic@health.nsw.gov.au
RI Frew, John/M-8446-2015; Vekic, Dunja/E-4657-2018
OI Frew, John/0000-0001-5042-3632; Vekic, Dunja/0000-0001-9412-1433
CR Blok J, 2014, BRIT J DERMATOL, V170, P1375, DOI 10.1111/bjd.12887
   Boer J, 2016, EXP DERMATOL, V25, P396, DOI 10.1111/exd.12926
   Boer J, 2016, DERMATOL CLIN, V34, P37, DOI 10.1016/j.det.2015.08.011
   Braun-Falco M, 2012, J AM ACAD DERMATOL, V66, P409, DOI 10.1016/j.jaad.2010.12.025
   Bruzzese V, 2012, JCR-J CLIN RHEUMATOL, V18, P413, DOI 10.1097/RHU.0b013e318278b84c
   Calao M, 2016, EPIDEMIOLOGY HIDRADE
   Canoui-Poitrine F, 2013, J INVEST DERMATOL, V133, P1506, DOI 10.1038/jid.2012.472
   Danby FW, 2015, J AM ACAD DERMATOL, V73, pS52, DOI 10.1016/j.jaad.2015.07.042
   Deckers IE, 2015, J AM ACAD DERMATOL, V72, P485, DOI 10.1016/j.jaad.2014.11.017
   Denny G, 2017, J AM ACAD DERMATOL, V76, P54, DOI 10.1016/j.jaad.2016.07.041
   Denny G, 2016, J AM ACAD DERMATOL, V75, P632, DOI 10.1016/j.jaad.2016.04.045
   Donoghue SE, 2014, AUSTRALAS J DERMATOL, V55, P301, DOI 10.1111/ajd.12209
   Egeberg A, 2016, JAMA DERMATOL, V152, P429, DOI 10.1001/jamadermatol.2015.6264
   Frew JW, 2017, AUSTRALAS J DERMATOL, V58, P13
   Frew JW, 2017, BRIT J DERMATOL, V177, P987, DOI 10.1111/bjd.15441
   Frew JW, 2015, EXP DERMATOL, V24, P338, DOI 10.1111/exd.12648
   Gisondi P, 2009, ACTAS DERMO-SIFILOGR, V100, P14, DOI 10.1016/S0001-7310(09)73373-3
   Gold DA, 2014, J AM ACAD DERMATOL, V70, P699, DOI 10.1016/j.jaad.2013.11.014
   Gross O, 2011, IMMUNOL REV, V243, P136, DOI 10.1111/j.1600-065X.2011.01046.x
   Hana A, 2007, LIFE SCI, V80, P2214, DOI 10.1016/j.lfs.2007.02.007
   Happle R, 2011, DERMATOLOGY, V222, P282, DOI 10.1159/000327923
   HARRISON BJ, 1985, BRIT J SURG, V72, P1002, DOI 10.1002/bjs.1800721223
   Hunger RE, 2008, BRIT J DERMATOL, V158, P691, DOI 10.1111/j.1365-2133.2007.08425.x
   Ingram JR, 2016, 25 EUR AC DERM VEN C
   Jemec GBE, 2015, J AM ACAD DERMATOL, V73, pS4, DOI 10.1016/j.jaad.2015.07.052
   KAHN MF, 1994, BAILLIERE CLIN RHEUM, V8, P333, DOI 10.1016/S0950-3579(94)80022-7
   Karagiannidis I, 2016, REV ENDOCR METAB DIS, V17, P335, DOI 10.1007/s11154-016-9366-z
   Kathju S, 2012, FEMS IMMUNOL MED MIC, V65, P385, DOI 10.1111/j.1574-695X.2012.00946.x
   Kohorst JJ, 2015, J AM ACAD DERMATOL, V73, pS27, DOI 10.1016/j.jaad.2015.07.055
   Kraft JN, 2007, J CUTAN MED SURG, V11, P125, DOI 10.2310/7750.2007.00019
   Kromann CB, 2014, BRIT J DERMATOL, V171, P819, DOI 10.1111/bjd.13090
   Kromann CB, 2014, ACTA DERM-VENEREOL, V94, P553, DOI 10.2340/00015555-1800
   Kurzen H, 2008, EXP DERMATOL, V17, P455, DOI [10.1111/j.1600-0625.2008.00712_1.x, 10.1111/j.1600-0625.2008.00712.x]
   Lavogiez C, 2010, DERMATOLOGY, V220, P147, DOI 10.1159/000269836
   Liy-Wong C, 2015, J AM ACAD DERMATOL, V73, pS36, DOI 10.1016/j.jaad.2015.07.051
   Mebazaa A, 2009, ACTA DERMATOVEN ALP, V18, P165
   Miller IM, 2014, JAMA DERMATOL, V150, P1273, DOI 10.1001/jamadermatol.2014.1165
   Moghaddas F, 2016, INTERN MED J, V46, P27, DOI 10.1111/imj.74_13197
   Monfrecola G, 2016, J EUR ACAD DERMATOL, V30, P1631, DOI 10.1111/jdv.13233
   MORTIMER PS, 1986, BMJ-BRIT MED J, V292, P245, DOI 10.1136/bmj.292.6515.245
   Nakatsuji T, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms2441
   Nguyen TV, 2013, J AM ACAD DERMATOL, V68, P834, DOI 10.1016/j.jaad.2012.11.002
   Paediatric Rheumatology International Trials Organisation (PRINTO), EUR PROJ
   Palmer RA, 2001, CLIN EXP DERMATOL, V26, P501, DOI 10.1046/j.1365-2230.2001.00876.x
   Pena ZG., 2015, Dermatol Online J, V21
   Pink AE, 2013, J INVEST DERMATOL, V133, P601, DOI 10.1038/jid.2012.372
   Prens E, 2015, J AM ACAD DERMATOL, V73, pS8, DOI 10.1016/j.jaad.2015.07.045
   Reeder VJ, 2014, J INVEST DERMATOL, V134, P2842, DOI 10.1038/jid.2014.220
   Revuz J, 2009, J EUR ACAD DERMATOL, V23, P985, DOI 10.1111/j.1468-3083.2009.03356.x
   Revuz JE, 2008, J AM ACAD DERMATOL, V59, P596, DOI 10.1016/j.jaad.2008.06.020
   Ring HC, 2017, BRIT J DERMATOL, V176, P993, DOI 10.1111/bjd.15007
   Ring HC, 2016, DERMATOL CLIN, V34, P29, DOI 10.1016/j.det.2015.08.010
   Sabat R, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031810
   Saraceno R, 2015, J AM ACAD DERMATOL, V72, pE42, DOI 10.1016/j.jaad.2014.10.002
   Scheinfeld Noah, 2013, Dermatol Online J, V19, P18558
   Schlapbach C, 2011, J AM ACAD DERMATOL, V65, P790, DOI 10.1016/j.jaad.2010.07.010
   Schrader AMR, 2014, J AM ACAD DERMATOL, V71, P460, DOI 10.1016/j.jaad.2014.04.001
   Schroder K, 2010, CELL, V140, P821, DOI 10.1016/j.cell.2010.01.040
   Shiels MS, 2014, JNCI-J NATL CANCER I, V106, DOI 10.1093/jnci/dju294
   Shlyankevich J, 2014, J AM ACAD DERMATOL, V71, P1144, DOI 10.1016/j.jaad.2014.09.012
   STELLON AJ, 1989, BRIT MED J, V298, P28, DOI 10.1136/bmj.298.6665.28
   Tzanetakou V, 2016, JAMA DERMATOL, V152, P52, DOI 10.1001/jamadermatol.2015.3903
   Tzellos T, 2015, BRIT J DERMATOL, V173, DOI 10.1111/bjd.14024
   van der Zee HH, 2011, BRIT J DERMATOL, V164, P1292, DOI 10.1111/j.1365-2133.2011.10254.x
   van der Zee HH, 2012, EXP DERMATOL, V21, P735, DOI 10.1111/j.1600-0625.2012.01552.x
   van der Zee HH, 2009, DERMATOLOGY, V219, P143, DOI 10.1159/000228337
   Vazquez BG, 2013, J INVEST DERMATOL, V133, P97, DOI 10.1038/jid.2012.255
   Vekic DA, 2015, MED TODAY, V16, P43
   Vekic DA, 2016, AUSTRALAS J DERMATOL, V57, P69, DOI 10.1111/ajd.12287
   Verdolini R, 2013, J EUR ACAD DERMATOL, V27, P1101, DOI 10.1111/j.1468-3083.2012.04668.x
   Vinding GR, 2014, BRIT J DERMATOL, V170, P884, DOI 10.1111/bjd.12787
   Vinkel C, 2017, J EUR ACAD DERMATOL, V31, DOI 10.1111/jdv.14225
   von Laffert M, 2010, EXP DERMATOL, V19, P533, DOI 10.1111/j.1600-0625.2009.00915.x
   Yazdanyar S, 2011, CURR OPIN INFECT DIS, V24, P118, DOI 10.1097/QCO.0b013e3283428d07
   Zouboulis CC, 2015, J EUR ACAD DERMATOL, V29, P619, DOI 10.1111/jdv.12966
NR 75
TC 34
Z9 35
U1 1
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0004-8380
EI 1440-0960
J9 AUSTRALAS J DERMATOL
JI Australas. J. Dermatol.
PD NOV
PY 2018
VL 59
IS 4
BP 267
EP 277
DI 10.1111/ajd.12770
PG 11
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA GZ7TQ
UT WOS:000449686900008
PM 29355905
DA 2025-06-11
ER

PT J
AU Zhou, JL
   Meng, XJ
   Deng, LG
   Liu, N
AF Zhou, Jianli
   Meng, Xiaojing
   Deng, Lugang
   Liu, Nan
TI Non-linear associations between metabolic syndrome and four typical
   heavy metals: Data from NHANES 2011-2018
SO CHEMOSPHERE
LA English
DT Article
DE Heavy metals; Logistic regression; Metabolic syndrome; Restricted cubic
   splines
ID KOREA NATIONAL-HEALTH; OXIDATIVE STRESS; MERCURY LEVEL; US ADULTS; LEAD;
   TOXICITY; EXPOSURE; CADMIUM; BLOOD; MANGANESE
AB Previous studies have found that heavy metals are associated with metabolic syndrome (MetS), although findings are inconsistent. Further, investigations into potential associations that consider age-or gender-specific effects and dose-response associations for metal exposure and MetS are rare. In this study, we explore the associations between blood levels of typical heavy metals [lead (Pb), cadmium (Cd), mercury (Hg) and manganese (Mn)] and MetS among adults using logistic regression analysis and restricted cubic splines (RCS) logistic analysis using data from the US National Health and Nutrition Examination Survey 2011-2018. After adjusting for covariates, higher levels of blood Pb, Cd and Hg were associated with lower risks of MetS in participants overall, and in all subgroup analyses, by logistic regression analysis (all P-values <0.05); in contrast, higher levels of blood Mn had a higher risk of MetS only in the age group of 30-49 years (P-values <0.05). We also found non-linear associations of heavy metal levels in blood with risk of MetS in participants overall, in specific age groups and in both genders, using RCS logistic regressions (all P-values <0.05). In addition, the non-linear associations of Pb and Hg we observed in different subgroups differed. In conclusion, blood levels of four heavy metals were associated with the risk of MetS through a variety of non-linear patterns.
C1 [Zhou, Jianli; Meng, Xiaojing; Liu, Nan] Southern Med Univ, Sch Publ Hlth, Dept Occupat Hlth & Occupat Med, Guangzhou 510515, Peoples R China.
   [Deng, Lugang; Liu, Nan] Shenzhen Univ, South China Hosp, Hlth Sci Ctr, Inst Environm & Hlth, Shenzhen 518116, Peoples R China.
   [Liu, Nan] Henan Univ, Sch Nursing & Hlth, Inst Chron Dis Risks Assessment, Kaifeng 475004, Peoples R China.
   [Liu, Nan] Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 540001, Peoples R China.
C3 Southern Medical University - China; Shenzhen University; Henan
   University; Zhengzhou University
RP Meng, XJ; Liu, N (corresponding author), Southern Med Univ, Sch Publ Hlth, Dept Occupat Hlth & Occupat Med, Guangzhou 510515, Peoples R China.
EM xiaojingmeng@smu.edu.cn; 13688869875@163.com
RI Liu, Nan/W-1842-2019; meng, xiaojing/B-7724-2019
OI Zhou, Jianli/0009-0002-7575-829X; Liu, Nan/0000-0002-8895-3169
FU National Natural Science Foundation of China [81872584, 81273078];
   National 863 Young Scientist Program [2015AA020940]; Natural Science
   Foundation of Guang-dong Province [2016A030313138]; Key Projects of
   Guangzhou Science and Technology Program [201704020056];
   Interdisci-plinary Research for First-class Discipline Construction
   Project of Henan University [2019YLXKJC04]; Scientific Research Project
   for Uni-versity of Education Bureau of Guangzhou [201831841]; Key
   Sci-entific Research Project Plan of Henan Province [21A330001]; Yellow
   River Scholar Fund of Henan University
FX This work was supported by National Natural Science Foundation of China
   (Nos. 81872584 and 81273078) , National 863 Young Scientist Program (No.
   2015AA020940) , Natural Science Foundation of Guang-dong Province (No.
   2016A030313138) , Key Projects of Guangzhou Science and Technology
   Program (No.201704020056) , Interdisci-plinary Research for First-class
   Discipline Construction Project of Henan University (No.2019YLXKJC04) ,
   Scientific Research Project for Uni-versity of Education Bureau of
   Guangzhou (No. 201831841) , Key Sci-entific Research Project Plan of
   Henan Province (No. 21A330001) and Yellow River Scholar Fund of Henan
   University.
CR Adams SV, 2014, J EXPO SCI ENV EPID, V24, P163, DOI 10.1038/jes.2013.55
   Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Balali-Mood M, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.643972
   Brodkin E, 2007, CAN MED ASSOC J, V176, P59
   Bulka CM, 2019, ENVIRON RES, V168, P397, DOI 10.1016/j.envres.2018.10.022
   Cao SZ, 2014, SCI TOTAL ENVIRON, V472, P1001, DOI 10.1016/j.scitotenv.2013.11.124
   Choi MK, 2013, BIOL TRACE ELEM RES, V156, P56, DOI 10.1007/s12011-013-9852-z
   Cobbina SJ, 2015, J HAZARD MATER, V294, P109, DOI 10.1016/j.jhazmat.2015.03.057
   Duan XY, 2017, ENVIRON SCI POLLUT R, V24, P24753, DOI 10.1007/s11356-017-0330-6
   El-Sorogy AS, 2020, MAR POLLUT BULL, V158, DOI 10.1016/j.marpolbul.2020.111411
   Ennouri R, 2010, ENVIRON MONIT ASSESS, V163, P229, DOI 10.1007/s10661-009-0829-5
   Ennouri R, 2016, ENVIRON SCI POLLUT R, V23, P5322, DOI 10.1007/s11356-015-5775-x
   Giacoppo S, 2014, BIOL TRACE ELEM RES, V161, P151, DOI 10.1007/s12011-014-0094-5
   Gong JH, 2020, DIABETES CARE, V43, P1344, DOI 10.2337/dc20-0243
   Grundy SM, 2016, TRENDS CARDIOVAS MED, V26, P364, DOI 10.1016/j.tcm.2015.10.004
   Hejna M, 2018, ANIMAL, V12, P2156, DOI 10.1017/S175173111700355X
   Henson MC, 2004, EXP BIOL MED, V229, P383, DOI 10.1177/153537020422900506
   Jin RF, 2018, ENVIRON INT, V121, P1355, DOI 10.1016/j.envint.2018.11.002
   Jomova K, 2011, TOXICOLOGY, V283, P65, DOI 10.1016/j.tox.2011.03.001
   Kabamba M, 2020, TOXICOL LETT, V332, P20, DOI 10.1016/j.toxlet.2020.06.007
   Lee BK, 2016, BIOL TRACE ELEM RES, V171, P6, DOI 10.1007/s12011-015-0499-9
   Lee BK, 2013, AM J IND MED, V56, P682, DOI 10.1002/ajim.22107
   Lo K, 2021, SCI TOTAL ENVIRON, V780, DOI 10.1016/j.scitotenv.2021.146527
   Mitra P, 2017, CRIT REV CL LAB SCI, V54, P506, DOI 10.1080/10408363.2017.1408562
   Moon SS, 2017, DIABETES METAB J, V41, P96, DOI 10.4093/dmj.2017.41.2.96
   Moon SS, 2014, ENDOCRINE, V46, P263, DOI 10.1007/s12020-013-0061-5
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   Noor N, 2018, ENVIRON INT, V121, P349, DOI 10.1016/j.envint.2018.08.029
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Padilla MA, 2010, INT J ENV RES PUB HE, V7, P3332, DOI 10.3390/ijerph7093332
   Park K, 2016, NUTRIENTS, V8, DOI 10.3390/nu8070424
   Planchart A, 2018, CURR ENV HLTH REP, V5, P110, DOI 10.1007/s40572-018-0182-3
   Poursafa P, 2014, ENVIRON SCI POLLUT R, V21, P13496, DOI 10.1007/s11356-014-3238-4
   Rai PK, 2019, ENVIRON INT, V125, P365, DOI 10.1016/j.envint.2019.01.067
   Rebelo FM, 2016, ENVIRON RES, V151, P671, DOI 10.1016/j.envres.2016.08.027
   Rhee SY, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-9
   Rokadia HK, 2013, CHEST, V143, P388, DOI 10.1378/chest.12-0595
   Shim YH, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16040671
   Smith D, 2002, ENVIRON HEALTH PERSP, V110, P263, DOI 10.1289/ehp.02110263
   Valko M, 2005, CURR MED CHEM, V12, P1161, DOI 10.2174/0929867053764635
   Vareda JP, 2019, J ENVIRON MANAGE, V246, P101, DOI 10.1016/j.jenvman.2019.05.126
   Wang X, 2018, ENVIRON INT, V121, P683, DOI 10.1016/j.envint.2018.09.035
   Whaley-Connell A, 2011, REV CARDIOVASC MED, V12, P21, DOI 10.3909/ricm0555
   Xu P, 2021, ENVIRON POLLUT, V273, DOI 10.1016/j.envpol.2021.116480
   Yang CC, 2017, J CLIN LIPIDOL, V11, P234, DOI 10.1016/j.jacl.2016.12.010
   Yao BD, 2020, SCI TOTAL ENVIRON, V726, DOI 10.1016/j.scitotenv.2020.138446
   Zhang WCB, 2020, ENVIRON INT, V143, DOI 10.1016/j.envint.2020.105959
   Zhou BA, 2016, BRIT J NUTR, V116, P853, DOI 10.1017/S0007114516002580
   Zhu FF, 2020, REPROD TOXICOL, V91, P53, DOI 10.1016/j.reprotox.2019.11.005
NR 50
TC 43
Z9 44
U1 0
U2 29
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD MAR
PY 2022
VL 291
AR 132953
DI 10.1016/j.chemosphere.2021.132953
EA JAN 2022
PN 2
PG 9
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA ZD1XP
UT WOS:000757999100004
PM 34800500
DA 2025-06-11
ER

PT J
AU Padhar, BC
   Dave, AR
   Nariya, M
AF Padhar, Bharatkumar C.
   Dave, Alankruta R.
   Nariya, Mukeshkumar
TI Acute toxicity and anti-dyslipidemic activity of Arogyavardhini
   compound in fructose-induced dyslipidemia in albino rats
SO INDIAN JOURNAL OF NATURAL PRODUCTS AND RESOURCES
LA English
DT Article
DE Acute toxicity; Antidyslipidemic activity; Arogyavardhini compound;
   Fructose; Metabolic syndrome
ID EMBLICA-OFFICINALIS; OXIDATIVE STRESS; GALLIC ACID; INSULIN;
   CONSUMPTION; PARAMETERS; GAERTN.; ROXB.
AB Metabolic syndrome is a co-occurrence of obesity, insulin resistance, hypertension, and dyslipidemia caused by improper diet and lifestyle. Arogyavardhini compound (AVC) contains an equal quantity of Arogyavardhini rasa and Lasuna powder. In clinical practice, Arogyavardhini Rasa is well known for its antidyslipidemic and weight lowering effect. Therefore, the present experimental study was designed to evaluate the safety of AVC on acute administration and anti-dyslipidemic activity in albino rats. An acute oral toxicity study for AVC was carried out by following OECD 425 guidelines. The anti-dyslipidemic activity was carried out against fructose-induced dyslipidemia in albino rats. No mortality and toxicity were observed and gross behaviours of all the albino rats were found normal during the experimental period of 14 days in the acute toxicity study. Fructose significantly increased blood sugar, triglycerides, SGPT, and alkaline phosphatase levels in albino rats in comparison to the control group. AVC treated group produced a decrease in serum triglyceride, transaminases, and alkaline phosphatase, which suggest that the drug has potential as anti-dyslipidemic and may be protective for degenerative changes produced by fructose in the liver, kidney, and heart of albino rats. From the present study it is concluded that AVC is safe up to an oral dose of 2000 mg/kg in albino rats and has exhibited a protective role in fructose-induced dyslipidemia in albino rats, hence may be useful in metabolic syndrome.
C1 [Padhar, Bharatkumar C.] Natl Inst Ayurveda, PG Dept Kayachikitsa, Jaipur 302002, Rajasthan, India.
   [Dave, Alankruta R.] Inst Teaching & Res Ayurveda, Dept Kayachikitsa, Jamnagar 361008, Gujarat, India.
   [Nariya, Mukeshkumar] Inst Teaching & Res Ayurveda, Pharmacol Lab, Jamnagar 361008, Gujarat, India.
RP Nariya, M (corresponding author), Inst Teaching & Res Ayurveda, Pharmacol Lab, Jamnagar 361008, Gujarat, India.
EM mukeshnariya@gmail.com
RI Padhar, Dr. Bharatkumar/F-7098-2014
CR Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   ALLEN KGD, 1978, ATHEROSCLEROSIS, V29, P81, DOI 10.1016/0021-9150(78)90096-5
   [Anonymous], 2001, CLASS 6 TOX INF SU 2, V12th
   [Anonymous], 2003, AYURVEDIC FORMULARY, V1, P258
   [Anonymous], 2003, RASAYOGA, V1, P258
   [Anonymous], 2012, GLOB BURD
   Bharatkumar C. P., 2016, Journal of Drug Delivery and Therapeutics, V6, P46
   Bhattacharya SK, 2002, PHYTOMEDICINE, V9, P171, DOI 10.1078/0944-7113-00090
   Bisht S., 2010, J Pharm Sci Res, V2, P622
   DiSilvestro RA, 2012, METABOLISM, V61, P1242, DOI 10.1016/j.metabol.2012.02.002
   Durak I, 2004, J NUTR BIOCHEM, V15, P373, DOI 10.1016/j.jnutbio.2004.01.005
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Fortuño A, 2006, DIABETES, V55, P209, DOI 10.2337/diabetes.55.1.209
   Goran MI, 2013, GLOB PUBLIC HEALTH, V8, P55, DOI 10.1080/17441692.2012.736257
   Hoang Khiet C, 2007, J Cardiometab Syndr, V2, P276, DOI 10.1111/j.1559-4564.2007.07491.x
   Husain G M, 2014, CELLMED, V4, P38
   HWANG IS, 1987, HYPERTENSION, V10, P512, DOI 10.1161/01.HYP.10.5.512
   Jadon A, 2007, J ETHNOPHARMACOL, V109, P214, DOI 10.1016/j.jep.2006.07.033
   Kumar Gajendra, 2013, J Ayurveda Integr Med, V4, P165, DOI 10.4103/0975-9476.118707
   Lamba N, 2015, INT J AYURVEDIC MED, V6, P24
   LIPNICK RL, 1995, FOOD CHEM TOXICOL, V33, P223, DOI 10.1016/0278-6915(94)00136-C
   Mishra B S, BHAVPRAKAS NIGHANT 2, V11th, P407
   Nicastro HL, 2015, CANCER PREV RES, V8, P181, DOI 10.1158/1940-6207.CAPR-14-0172
   OECD 425, 2006, OECD GUIDELINE TESTI
   Paget G E., 1964, Evaluationof drug activities, Pharmacometrics, VI, P161
   Poltanov EA, 2009, PHYTOTHER RES, V23, P1309, DOI 10.1002/ptr.2775
   Prativadibhayankaram VS, 2008, NAT PROD COMMUN, V3, P251
   Ramesh K, 2007, INT J PHARM BIOMED, V10, P111
   Reinhart KM, 2009, NUTR RES REV, V22, P39, DOI 10.1017/S0954422409350003
   Sato Y, 1996, TISSUE CELL, V28, P637, DOI 10.1016/S0040-8166(96)80067-X
   SATYAVATI GV, 1988, INDIAN J MED RES, V87, P327
   Sharma A, 2009, ASIAN J CHEM, V21, P7111
   Sheth D B, 2012, INT J U PHARM LIFE S, V2, P140
   Stanhope KL, 2008, CURR OPIN LIPIDOL, V19, P16, DOI 10.1097/MOL.0b013e3282f2b24a
   Suchalatha Subramaniyan, 2005, Exp Clin Cardiol, V10, P91
   Sultana Sarwat, 2005, Indian Journal of Experimental Biology, V43, P430
   Swarbrick MM, 2008, BRIT J NUTR, V100, P947, DOI 10.1017/S0007114508968252
   Teff KL, 2004, J CLIN ENDOCR METAB, V89, P2963, DOI 10.1210/jc.2003-031855
   Tesfaye A., 2015, INT J SCI RES SCI EN, V1, P142
   Urizar NL, 2002, SCIENCE, V296, P1703, DOI 10.1126/science.1072891
   Vagbhata Astanga Hrdayam, 2000, ASTANGA HRDAYAM CHIK, V1st, P824
NR 41
TC 1
Z9 1
U1 0
U2 0
PU NATL INST SCIENCE COMMUNICATION & INFORMATION RESOURCES-NISCAIR
PI NEW DELHI
PA DR K S KRISHNAN MARG, PUSA CAMPUS, NEW DELHI, 110 012, INDIA
SN 0976-0504
EI 0976-0512
J9 INDIAN J NAT PROD RE
JI Indian J. Nat. Prod. Resour.
PD SEP
PY 2021
VL 12
IS 3
BP 384
EP 390
PG 7
WC Plant Sciences
WE Emerging Sources Citation Index (ESCI)
SC Plant Sciences
GA WZ1KM
UT WOS:000719732000006
DA 2025-06-11
ER

PT J
AU Byrne, CD
   Targher, G
AF Byrne, Christopher D.
   Targher, Giovanni
TI NAFLD as a driver of chronic kidney disease
SO JOURNAL OF HEPATOLOGY
LA English
DT Review
DE Non-alcoholic fatty liver disease; Type 2 diabetes; Insulin resistance;
   Metabolic syndrome; Dysbiosis; Adipose tissue; Gut microbiota; CKD
ID FATTY LIVER-DISEASE; GAMMA-GLUTAMYL-TRANSFERASE; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; ADIPOSE-TISSUE; INSULIN-RESISTANCE;
   GASTROINTESTINAL-TRACT; INTESTINAL MICROBIOTA; ACID CONCENTRATIONS;
   HEPATIC STEATOSIS
AB Non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) are worldwide public health problems, affecting up to 25-30% (NAFLD), and up to 10-15% (CKD) of the general population. Recently, it has also been established that there is a strong association between NAFLD and CKD, regardless of the presence of potential confounding diseases such as obesity, hypertension and type 2 diabetes. Since NAFLD and CKD are both common diseases that often occur alongside other metabolic conditions, such as type 2 diabetes or metabolic syndrome, elucidating the relative impact of NAFLD on the risk of incident CKD presents a substantial challenge for investigators working in this research field. A growing body of epidemiological evidence suggests that NAFLD is an independent risk factor for CKD and recent evidence also suggests that associated factors such as metabolic syndrome, dysbiosis, unhealthy diets, platelet activation and processes associated with ageing could also contribute mechanisms linking NAFLD and CKD. This narrative review provides an overview of the literature on: a) the evidence for an association and causal link between NAFLD and CKD and b) the underlying mechanisms by which NAFLD (and factors strongly linked with NAFLD) may increase the risk of developing CKD. (C) 2020 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
C1 [Byrne, Christopher D.] Univ Southampton, Fac Med, Nutr & Metab, Southampton SO16 6YD, Hants, England.
   [Byrne, Christopher D.] Univ Hosp Southampton, Southampton Natl Inst Hlth Res Biomed Res Ctr, Southampton, Hants, England.
   [Targher, Giovanni] Univ Verona, Dept Med, Div Endocrinol Diabet & Metab, Verona, Italy.
   [Targher, Giovanni] Azienda Osped Univ Integrata Verona, Verona, Italy.
C3 University of Southampton; University of Verona; University of Verona;
   Azienda Ospedaliera Universitaria Integrata Verona
RP Byrne, CD (corresponding author), Univ Southampton, Fac Med, Nutr & Metab, Southampton SO16 6YD, Hants, England.; Targher, G (corresponding author), Univ Verona, Dept Med, Div Endocrinol Diabet & Metab, Verona, Italy.; Targher, G (corresponding author), Azienda Osped Univ Integrata Verona, Verona, Italy.
EM cdtb@soton.ac.uk; giovanni.targher@univr.it
RI Targher, Giovanni/AAB-9008-2019
OI Targher, Giovanni/0000-0002-4325-3900; Byrne, Christopher
   D/0000-0001-6322-7753
FU Southampton NIHR Biomedical Research Centre, UK [IS-BRC-20004];
   University School of Medicine of Verona, Verona, Italy
FX C.D.B. is supported in part by the Southampton NIHR Biomedical Research
   Centre (IS-BRC-20004), UK. G.T. is supported in part by grants from the
   University School of Medicine of Verona, Verona, Italy.
CR Adams LA, 2017, GUT, V66, P1138, DOI 10.1136/gutjnl-2017-313884
   Ahn AL, 2013, KOREAN J FAM MED, V34, P199, DOI 10.4082/kjfm.2013.34.3.199
   Akbari A, 2015, AM J KIDNEY DIS, V65, P177, DOI 10.1053/j.ajkd.2014.10.013
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alexopoulos N, 2014, ATHEROSCLEROSIS, V233, P104, DOI 10.1016/j.atherosclerosis.2013.12.023
   Anstee QM, 2016, GASTROENTEROLOGY, V150, P1728, DOI 10.1053/j.gastro.2016.01.037
   Arase Y, 2011, INTERNAL MED, V50, P1081, DOI 10.2169/internalmedicine.50.5043
   Ashraf NU, 2015, FREE RADICAL RES, V49, P1405, DOI 10.3109/10715762.2015.1078461
   Bellentani S, 2017, LIVER INT, V37, P81, DOI 10.1111/liv.13299
   Brandl K, 2017, CURR OPIN GASTROEN, V33, P128, DOI 10.1097/MOG.0000000000000349
   Briskey D, 2017, CLIN EXP NEPHROL, V21, P7, DOI 10.1007/s10157-016-1255-y
   Brown KE, 2005, HISTOL HISTOPATHOL, V20, P429, DOI 10.14670/HH-20.429
   Brück K, 2016, J AM SOC NEPHROL, V27, P2135, DOI 10.1681/ASN.2015050542
   Byrne CD, 2012, DIABETIC MED, V29, P1098, DOI 10.1111/j.1464-5491.2012.03732.x
   Byrne CD, 2020, NAT REV GASTRO HEPAT, V17, P70, DOI 10.1038/s41575-019-0239-2
   Byrne CD, 2018, BMJ-BRIT MED J, V362, DOI 10.1136/bmj.k2734
   Byrne CD, 2015, J HEPATOL, V62, pS47, DOI 10.1016/j.jhep.2014.12.012
   Byrne CD, 2014, ARTERIOSCL THROM VAS, V34, P1155, DOI 10.1161/ATVBAHA.114.303034
   Cai DS, 2005, NAT MED, V11, P183, DOI 10.1038/nm1166
   Chang Y, 2008, METABOLISM, V57, P569, DOI 10.1016/j.metabol.2007.11.022
   Chen PC, 2020, J FORMOS MED ASSOC, V119, P42, DOI 10.1016/j.jfma.2019.02.010
   Chung S, 2019, ADV NUTR, V10, P888, DOI 10.1093/advances/nmz028
   Coresh J, 2007, JAMA-J AM MED ASSOC, V298, P2038, DOI 10.1001/jama.298.17.2038
   Couser WG, 2011, KIDNEY INT, V80, P1258, DOI 10.1038/ki.2011.368
   CUMMINGS JH, 1983, LANCET, V1, P1206
   Di Costanzo A, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20184444
   Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI23621
   Dounousi E, 2006, AM J KIDNEY DIS, V48, P752, DOI 10.1053/j.ajkd.2006.08.015
   Duni A, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20153711
   Duni A, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/9036450
   EASL, 2016, OBESITY FACTS, V9, P65, DOI [10.1159/000443344, 10.1007/s00125-016-3902-y, 10.1016/j.jhep.2015.11.004]
   Eckardt KU, 2013, LANCET, V382, P158, DOI 10.1016/S0140-6736(13)60439-0
   Eknoyan G, 2002, AM J KIDNEY DIS, V39, pS14, DOI 10.1053/ajkd.2002.30939
   Engin A, 2017, ADV EXP MED BIOL, V960, P221, DOI 10.1007/978-3-319-48382-5_9
   Engin A, 2017, ADV EXP MED BIOL, V960, P443, DOI 10.1007/978-3-319-48382-5_19
   Englyst NA, 2003, DIABETES, V52, P1248, DOI 10.2337/diabetes.52.5.1248
   Eslam M, 2018, J HEPATOL, V68, P268, DOI 10.1016/j.jhep.2017.09.003
   Evenepoel P, 2017, PEDIATR NEPHROL, V32, P2005, DOI 10.1007/s00467-016-3527-x
   Fuentes E, 2018, TRENDS CARDIOVAS MED, V28, P429, DOI 10.1016/j.tcm.2018.03.001
   Gremmel T, 2013, NEPHROL DIAL TRANSPL, V28, P2116, DOI 10.1093/ndt/gft103
   Halilbasic E, 2016, DIGEST DIS, V34, P580, DOI 10.1159/000445268
   Hannou SA, 2018, J CLIN INVEST, V128, P545, DOI 10.1172/JCI96702
   Hill NR, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0158765
   Himmelfarb J, 2002, KIDNEY INT, V62, P1524, DOI 10.1046/j.1523-1755.2002.00600.x
   Holt HB, 2006, DIABETOLOGIA, V49, P141, DOI 10.1007/s00125-005-0070-x
   Huh JH, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0180951
   Hunt NJ, 2019, COMPUT STRUCT BIOTEC, V17, P1151, DOI 10.1016/j.csbj.2019.07.021
   Hwang ST, 2010, INTERN MED J, V40, P437, DOI 10.1111/j.1445-5994.2009.01979.x
   Ix JH, 2010, J AM SOC NEPHROL, V21, P406, DOI 10.1681/ASN.2009080820
   Jang HR, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-23014-0
   Jennison E, 2019, POSTGRAD MED J, V95, P314, DOI 10.1136/postgradmedj-2018-136316
   Jiang WW, 2015, SCI REP-UK, V5, DOI 10.1038/srep08096
   John GB, 2011, AM J KIDNEY DIS, V58, P127, DOI 10.1053/j.ajkd.2010.12.027
   Johnson RJ, 2009, ENDOCR REV, V30, P96, DOI 10.1210/er.2008-0033
   Kendrick J, 2008, NAT CLIN PRACT NEPHR, V4, P672, DOI 10.1038/ncpneph0954
   Kidney Disease, 2013, Kidney Int Suppl, V3, P1, DOI DOI 10.1038/KISUP.2012.73
   Kim HN, 2019, J CLIN MED, V8, DOI 10.3390/jcm8081089
   Kramann R, 2014, SEMIN NEPHROL, V34, P374, DOI 10.1016/j.semnephrol.2014.06.004
   Krötz F, 2004, ARTERIOSCL THROM VAS, V24, P1988, DOI 10.1161/01.ATV.0000145574.90840.7d
   Kunutsor SK, 2017, CLIN CHIM ACTA, V473, P39, DOI 10.1016/j.cca.2017.08.014
   Lanaspa MA, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3434
   Lanaspa MA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048801
   Lanaspa MA, 2012, J BIOL CHEM, V287, P40732, DOI 10.1074/jbc.M112.399899
   Le Blanc J, 2019, FRONT CARDIOVASC MED, V6, DOI 10.3389/fcvm.2019.00109
   Levey AS, 2017, CLIN PHARMACOL THER, V102, P405, DOI 10.1002/cpt.729
   Li L, 2019, ADV EXP MED BIOL, V1165, P407, DOI 10.1007/978-981-13-8871-2_19
   Lonardo A, 2018, J HEPATOL, V68, P335, DOI 10.1016/j.jhep.2017.09.021
   Lonardo A, 2015, DIGEST LIVER DIS, V47, P997, DOI 10.1016/j.dld.2015.08.004
   Luo KX, 2019, TURK J GASTROENTEROL, V30, P611, DOI 10.5152/tjg.2019.18343
   Machado MV, 2012, LIVER INT, V32, P241, DOI 10.1111/j.1478-3231.2011.02623.x
   Mahmoodpoor F, 2017, BIOMED PHARMACOTHER, V93, P412, DOI 10.1016/j.biopha.2017.06.066
   Malehmir M, 2019, NAT MED, V25, P641, DOI 10.1038/s41591-019-0379-5
   Mantovani A, 2019, DIABETES METAB, V45, P480, DOI 10.1016/j.diabet.2019.01.011
   Mantovani A, 2018, METABOLISM, V79, P64, DOI 10.1016/j.metabol.2017.11.003
   Mantovani A, 2018, DIABETES CARE, V41, P372, DOI 10.2337/dc17-1902
   Marcuccilli M, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17040562
   Martin G, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01153
   Marzuillo P, 2019, PEDIATR OBES, V14, DOI 10.1111/ijpo.12539
   Mencke R, 2017, AGEING RES REV, V35, P124, DOI 10.1016/j.arr.2016.09.001
   Mosca A, 2017, J HEPATOL, V66, P1031, DOI 10.1016/j.jhep.2016.12.025
   Mouzaki M, 2013, HEPATOLOGY, V58, P120, DOI 10.1002/hep.26319
   Musso G, 2017, CLIN GASTROENTEROL H, V15, P972, DOI 10.1016/j.cgh.2016.08.002
   Musso G, 2016, DIABETES CARE, V39, P1830, DOI 10.2337/dc15-1182
   Musso G, 2015, HEPATOLOGY, V62, P658, DOI 10.1002/hep.27643
   Musso G, 2014, PLOS MED, V11, DOI 10.1371/journal.pmed.1001680
   Nampoothiri RV, 2019, J CLIN EXP HEPATOL, V9, P22, DOI 10.1016/j.jceh.2017.12.005
   Olejnik A, 2018, BIOMED RES INT, V2018, DOI 10.1155/2018/5171945
   Olufadi R, 2006, PATHOPHYSIOL HAEMO T, V35, P281, DOI 10.1159/000093221
   Oniki K, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0132640
   Önnerhag K, 2019, SCAND J GASTROENTERO, V54, P328, DOI 10.1080/00365521.2019.1583366
   Önnerhag K, 2019, CLIN RES HEPATOL GAS, V43, P542, DOI 10.1016/j.clinre.2019.02.004
   Pacifico L, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17081218
   Paik J, 2019, LIVER INT, V39, P342, DOI 10.1111/liv.13992
   Palmer AK, 2019, DIABETOLOGIA, V62, P1835, DOI 10.1007/s00125-019-4934-x
   Pan LL, 2015, METABOLISM, V64, P1077, DOI 10.1016/j.metabol.2015.06.003
   Park CW, 2011, CLIN TRANSPLANT, V25, pE606, DOI 10.1111/j.1399-0012.2011.01497.x
   Park H, 2019, J INTERN MED, V286, P711, DOI 10.1111/joim.12964
   Passmore IJ, 2018, PLOS PATHOG, V14, DOI 10.1371/journal.ppat.1007191
   Pavlovic N, 2019, CANCERS, V11, DOI 10.3390/cancers11071022
   Pawlak M, 2015, J HEPATOL, V62, P720, DOI 10.1016/j.jhep.2014.10.039
   Pirazzi C, 2014, HUM MOL GENET, V23, P4077, DOI 10.1093/hmg/ddu121
   Prasad G V Ramesh, 2014, World J Nephrol, V3, P210, DOI 10.5527/wjn.v3.i4.210
   Reilly SM, 2017, NAT REV ENDOCRINOL, V13, P633, DOI 10.1038/nrendo.2017.90
   Rosso C, 2019, J HEPATOL, V71, P1012, DOI 10.1016/j.jhep.2019.06.031
   Ryu S, 2007, CLIN CHEM, V53, P71, DOI 10.1373/clinchem.2006.078980
   Sabatino A, 2017, CURR DIABETES REP, V17, DOI 10.1007/s11892-017-0841-z
   Sanchez-Lozada LG, 2019, J BIOL CHEM, V294, P4272, DOI 10.1074/jbc.RA118.006158
   Scorletti E, 2016, DIGEST DIS, V34, P11, DOI 10.1159/000447276
   Shaw I, 2018, NAT REV NEPHROL, V14, P521, DOI 10.1038/s41581-018-0032-4
   Shen ZW, 2017, INT UROL NEPHROL, V49, P303, DOI 10.1007/s11255-016-1429-2
   Shoelson SE, 2007, GASTROENTEROLOGY, V132, P2169, DOI 10.1053/j.gastro.2007.03.059
   Sinn DH, 2017, J HEPATOL, V67, P1274, DOI 10.1016/j.jhep.2017.08.024
   Siragy HM, 2010, AM J NEPHROL, V31, P541, DOI 10.1159/000313363
   Sirota JC, 2012, AM J NEPHROL, V36, P466, DOI 10.1159/000343885
   Small DM, 2012, NEPHROLOGY, V17, P311, DOI 10.1111/j.1440-1797.2012.01572.x
   Stolarczyk E, 2017, CURR OPIN PHARMACOL, V37, P35, DOI 10.1016/j.coph.2017.08.006
   Sumida Y, 2013, FREE RADICAL RES, V47, P869, DOI 10.3109/10715762.2013.837577
   Sun DQ, 2020, LIVER INT, V40, P107, DOI 10.1111/liv.14251
   Targher G, 2008, DIABETOLOGIA, V51, P444, DOI 10.1007/s00125-007-0897-4
   Targher G, 2010, DIABETOLOGIA, V53, P1341, DOI 10.1007/s00125-010-1720-1
   Targher G, 2008, J AM SOC NEPHROL, V19, P1564, DOI 10.1681/ASN.2007101155
   Targher G, 2019, HEPATOLOGY, V70, P142, DOI 10.1002/hep.30625
   Targher G, 2017, NAT REV NEPHROL, V13, P297, DOI 10.1038/nrneph.2017.16
   Targher G, 2016, J HEPATOL, V65, P589, DOI 10.1016/j.jhep.2016.05.013
   Targher G, 2014, AM J KIDNEY DIS, V64, P638, DOI 10.1053/j.ajkd.2014.05.019
   Targher G, 2014, DIABETES CARE, V37, P1729, DOI 10.2337/dc13-2704
   Targher G, 2013, SEMIN THROMB HEMOST, V39, P214, DOI 10.1055/s-0033-1334866
   Targher G, 2010, CLIN J AM SOC NEPHRO, V5, P2166, DOI 10.2215/CJN.05050610
   Targher G, 2009, SEMIN THROMB HEMOST, V35, P277, DOI 10.1055/s-0029-1222606
   Thomas G, 2011, CLIN J AM SOC NEPHRO, V6, P2364, DOI 10.2215/CJN.02180311
   Tucker PS, 2013, BIOMARKERS, V18, P103, DOI 10.3109/1354750X.2012.749302
   Vaziri ND, 2004, SEMIN NEPHROL, V24, P469, DOI 10.1016/j.semnephrol.2004.06.026
   Vilar-Gomez E, 2017, ALIMENT PHARM THER, V45, P332, DOI 10.1111/apt.13860
   Wieland A, 2015, ALIMENT PHARM THER, V42, P1051, DOI 10.1111/apt.13376
   Wild SH, 2018, DIABETES CARE, V41, P341, DOI 10.2337/dc17-1590
   Wilechansky RM, 2019, LIVER INT, V39, P1535, DOI 10.1111/liv.14125
   Yang K, 2017, BLOOD, V129, P2667, DOI 10.1182/blood-2016-10-744060
   Yasui K, 2011, METABOLISM, V60, P735, DOI 10.1016/j.metabol.2010.07.022
   Yilmaz Y, 2010, METABOLISM, V59, P1327, DOI 10.1016/j.metabol.2009.12.012
   Younossi Z, 2018, NAT REV GASTRO HEPAT, V15, P11, DOI 10.1038/nrgastro.2017.109
   Younossi ZM, 2019, TRANSPLANTATION, V103, P22, DOI 10.1097/TP.0000000000002484
   Zhu LX, 2013, HEPATOLOGY, V57, P601, DOI 10.1002/hep.26093
NR 142
TC 292
Z9 301
U1 2
U2 85
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0168-8278
EI 1600-0641
J9 J HEPATOL
JI J. Hepatol.
PD APR
PY 2020
VL 72
IS 4
BP 785
EP 801
DI 10.1016/j.jhep.2020.01.013
PG 17
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA KU9NH
UT WOS:000520050900022
PM 32059982
OA Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Romero-Nava, R
   Zhou, DS
   García, N
   Ruiz-Hernández, A
   Si, YC
   Sánchez-Muñoz, F
   Huang, FY
   Hong, E
   Villafaña, S
AF Romero-Nava, Rodrigo
   Zhou, De-Shan
   Garcia, Noemi
   Ruiz-Hernandez, Armando
   Si, Yin-Chu
   Sanchez-Munoz, Fausto
   Huang, Fengyang
   Hong, Enrique
   Villafana, Santiago
TI Evidence of alterations in the expression of orphan receptors GPR26 and
   GPR39 due to the etiology of the metabolic syndrome
SO JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
LA English
DT Article
DE Metabolic syndrome; orphan receptors; GPR26; GPR39V1; GPR39V2
ID PROTEIN-COUPLED RECEPTOR; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   ANGIOTENSIN-II; FRUCTOSE; MECHANISMS; GENE; HYPERTENSION; SYSTEM; TYPE-2
AB Aims: Metabolic syndrome (MS) is composed of several metabolic abnormalities that increase the risk of cardiovascular diseases and diabetes. Although there are treatments for the components of MS, this pathology maintains a high mortality, suggesting that there are other mechanisms in which orphan receptors such as GPR26 and GPR39 may be involved. For this reason, the aim of this work was to evaluate the expression of GPR26 and GPR39 orphan receptors in two models of MS (diet and genetics).
   Materials and methods: We used male Wistar rats, which received 70% fructose in drinking water for 9 weeks, and obese Zucker rats. We measured weight, blood pressure, glucose, triglycerides, total cholesterol, HDL cholesterol, LDL cholesterol to determine the MS and the expression of the orphan receptors GPR26 and GPR39 in brain, heart, aorta, liver, and kidney by RT-PCR.
   Results: The analysis of the expression of the orphan receptors GPR26 and GPR39 showed that the receptors are expressed in some tissues, but the expression of the GPR26 tends to decrease in the heart and aorta, whereas in the brain, no changes were observed, this receptor is not expressed in the liver and kidney of both strains. The expression of GPR39 isoforms depends on the tissue and MS model.
   Conclusions: We conclude that the orphan receptors GPR26, GPR39v1, and GPR39v2 are expressed in different tissues and their profile expression is dependent on the etiology of the MS.
C1 [Romero-Nava, Rodrigo; Ruiz-Hernandez, Armando; Villafana, Santiago] Inst Politecn Nacl, Lab Senalizac Intracelular, Escuela Super Med, Secc Posgrad, Mexico City, DF, Mexico.
   [Zhou, De-Shan] Capital Med Univ, Dept Histol & Embryol, Beijing, Peoples R China.
   [Garcia, Noemi] Tecnol Monterrey, Escuela Nacl Med, Monterrey, NL, Mexico.
   [Garcia, Noemi] Hosp Zambrano Hellio, Ctr Invest Basica & Transferencia, Garza Garcia, NL, Mexico.
   [Si, Yin-Chu] Beijing Univ Chinese Med, Dept Anat, Beijing, Peoples R China.
   [Sanchez-Munoz, Fausto] Inst Nacl Cardiol Ignacio Chavez, Dept Inmunol, Mexico City, DF, Mexico.
   [Huang, Fengyang] HIMFG, Dept Farmacol & Toxicol, Mexico City, DF, Mexico.
   [Hong, Enrique] Ctr Invest & Estudios Avanzados, Dept Farmacobiol, Mexico City, DF, Mexico.
C3 Instituto Politecnico Nacional - Mexico; Capital Medical University;
   Tecnologico de Monterrey; Beijing University of Chinese Medicine;
   National Institute of Cardiology - Mexico; CINVESTAV - Centro de
   Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional
RP Villafaña, S (corresponding author), Inst Politecn Nacl, Lab Senalizac Intracelular, Escuela Super Med, Secc Posgrad, Mexico City, DF, Mexico.
EM svillafana@ipn.mx
RI Sanchez-Muñoz, Fausto/KIE-6221-2024; Huang, Fengyang/AAF-8605-2021;
   Garcia, Noemi/T-4688-2019
OI SANCHEZ-MUNOZ, FAUSTO/0000-0001-6556-1632; Ruiz Hernandez,
   Armando/0000-0002-3855-2981; Huang, Fengyang/0000-0002-6503-694X; Noemi,
   Garcia/0000-0002-1137-0117
FU Consejo Nacional de Ciencia y Tecnologia [CONACYT CB-1012-01-183660];
   Secretaria de Investigacion y Posgrado del Instituto Politecnico
   Nacional [SIP-IPN-20161519]; CONACYT scholarship [389327]
FX This work was supported by grants CONACYT CB-1012-01-183660 (Consejo
   Nacional de Ciencia y Tecnologia), project SIP-IPN-20161519 (Secretaria
   de Investigacion y Posgrado del Instituto Politecnico Nacional), and
   CONACYT scholarship to the student Rodrigo Romero Nava (389327).
CR Ahangarpour A, 2012, IRAN J MED SCI, V37, P181
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alonso A, 1996, EUR J IMMUNOL, V26, P2165, DOI 10.1002/eji.1830260931
   Auclair G, 2012, BIOCHIMIE, V94, P2202, DOI 10.1016/j.biochi.2012.05.016
   Banday AA, 2007, HYPERTENSION, V49, P664, DOI 10.1161/01.HYP.0000255233.56410.20
   Bergman RN, 2000, TRENDS ENDOCRIN MET, V11, P351, DOI 10.1016/S1043-2760(00)00323-4
   Blomqvist M, 2005, DIABETES-METAB RES, V21, P158, DOI 10.1002/dmrr.519
   Boyda HN, 2013, J NEUROENDOCRINOL, V25, P217, DOI 10.1111/jne.12002
   Bresnick JN, 2003, ASSAY DRUG DEV TECHN, V1, P239, DOI 10.1089/15406580360545053
   Bundalo M, 2015, HORM METAB RES, V47, P521, DOI 10.1055/s-0034-1394373
   Bundalo MM, 2016, J RENIN-ANGIO-ALDO S, V17, DOI 10.1177/1470320316642915
   Cawley NX, 2012, ENDOCRINOLOGY, V153, P3561, DOI 10.1210/en.2012-1562
   Chakravarty K, 2004, J BIOL CHEM, V279, P15385, DOI 10.1074/jbc.M309905200
   Chen DH, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0040764
   Chevalier N, 2016, PRESSE MED, V45, P88, DOI 10.1016/j.lpm.2015.08.008
   Civelli O, 1998, FEBS LETT, V430, P55, DOI 10.1016/S0014-5793(98)00524-9
   Davenport AP, 2013, PHARMACOL REV, V65, P967, DOI 10.1124/pr.112.007179
   De Angelis K, 2012, AM J PHYSIOL-REG I, V302, pR950, DOI 10.1152/ajpregu.00450.2011
   Di Rienzo A, 2005, TRENDS GENET, V21, P596, DOI 10.1016/j.tig.2005.08.007
   Ding Q, 2016, J AFFECT DISORDERS, V197, P100, DOI 10.1016/j.jad.2016.03.017
   Dornas WC, 2013, J NUTR BIOCHEM, V24, P2016, DOI 10.1016/j.jnutbio.2013.06.006
   Downing LE, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600347
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Egerod KL, 2007, MOL ENDOCRINOL, V21, P1685, DOI 10.1210/me.2007-0055
   Farah V, 2007, AM J PHYSIOL-HEART C, V293, pH1083, DOI 10.1152/ajpheart.00106.2006
   Farah V, 2006, AUTON NEUROSCI-BASIC, V130, P41, DOI 10.1016/j.autneu.2006.05.006
   Ferder L, 2010, CURR HYPERTENS REP, V12, P105, DOI 10.1007/s11906-010-0097-3
   Havel PJ, 2005, NUTR REV, V63, P133, DOI [10.1301/nr.2005.may.133-157, 10.1111/j.1753-4887.2005.tb00132.x]
   Holst B, 2004, J BIOL CHEM, V279, P53806, DOI 10.1074/jbc.M407676200
   Holst B, 2007, ENDOCRINOLOGY, V148, P13, DOI 10.1210/en.2006-0933
   Ishitobi Y, 2012, NEUROSCI RES, V72, P257, DOI 10.1016/j.neures.2011.12.002
   Jackson VR, 2006, NEUROREPORT, V17, P813, DOI 10.1097/01.wnr.0000215779.76602.93
   Jones PG, 2007, BBA-GEN SUBJECTS, V1770, P890, DOI 10.1016/j.bbagen.2007.01.013
   Joost P, 2002, GENOME BIOL, V3
   KASISKE BL, 1992, HYPERTENSION, V19, pI110, DOI 10.1161/01.HYP.19.1_Suppl.I110
   Khan MZ, 2016, BIOMED PHARMACOTHER, V79, P263, DOI 10.1016/j.biopha.2016.02.026
   Kim JK, 2009, CELL MOL LIFE SCI, V66, P596, DOI 10.1007/s00018-008-8432-4
   Kinote A, 2012, ENDOCRINOLOGY, V153, P3633, DOI 10.1210/en.2012-1341
   KOBAYASHI R, 1993, HYPERTENSION, V21, P1051, DOI 10.1161/01.HYP.21.6.1051
   Kolodziejski PA, 2017, J DIABETES, V9, P353, DOI 10.1111/1753-0407.12417
   Lê KA, 2006, CURR OPIN CLIN NUTR, V9, P469, DOI 10.1097/01.mco.0000232910.61612.4d
   Lee DK, 2000, BBA-GENE STRUCT EXPR, V1490, P311, DOI 10.1016/S0167-4781(99)00241-9
   Leonard S, 2016, SCI REP-UK, V6, DOI 10.1038/srep27002
   Limberg JK, 2016, FRONT PHYSIOL, V7, DOI 10.3389/fphys.2016.00215
   Llarena M, 2016, J PHYSIOL BIOCHEM, V72, P555, DOI 10.1007/s13105-015-0457-1
   Martin AL, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0138463
   MCGARRY JD, 1995, BIOCHEM SOC T, V23, P321, DOI 10.1042/bst0230321
   Mlyniec K, 2014, NEUROPHARMACOLOGY, V79, P290, DOI 10.1016/j.neuropharm.2013.12.001
   Moohammadaree A, 2015, PHYTOTHER RES, V29, P1806, DOI 10.1002/ptr.5448
   Moran BM, 2016, ACTA DIABETOL, V53, P279, DOI 10.1007/s00592-015-0781-5
   Mori F, 2016, NEUROPATHOLOGY, V36, P50, DOI 10.1111/neup.12237
   Muñoz M, 2015, FREE RADICAL BIO MED, V84, P77, DOI 10.1016/j.freeradbiomed.2015.03.024
   Nasri R, 2015, CHEM-BIOL INTERACT, V242, P71, DOI 10.1016/j.cbi.2015.08.003
   Rochlani Y, 2015, CARDIOVASC DRUG THER, V29, P329, DOI 10.1007/s10557-015-6593-6
   Rodefeld MD, 1996, J CARDIOVASC ELECTR, V7, P1039, DOI 10.1111/j.1540-8167.1996.tb00479.x
   Roncal-Jimenez CA, 2016, AM J PHYSIOL-RENAL, V311, pF722, DOI 10.1152/ajprenal.00306.2016
   Ruiz-Hernández A, 2015, J RECEPT SIG TRANSD, V35, P46, DOI 10.3109/10799893.2014.926926
   Sánchez A, 2014, J SEX MED, V11, P1463, DOI 10.1111/jsm.12526
   Santos-Zas I, 2016, CELL MOL LIFE SCI, V73, P617, DOI 10.1007/s00018-015-1994-z
   Schäff CT, 2015, J DAIRY SCI, V98, P1046, DOI 10.3168/jds.2014-8636
   Schmid E, 2015, NAT MED, V21, P1298, DOI 10.1038/nm.3972
   Senador D, 2010, J CARDIOVASC PHARM T, V15, P68, DOI 10.1177/1074248409351409
   Serkova NJ, 2006, J HEPATOL, V44, P956, DOI 10.1016/j.jhep.2005.07.009
   Sharabi Y, 2007, AM J HYPERTENS, V20, P206, DOI 10.1016/j.amjhyper.2006.08.002
   Shulman GI, 2000, J CLIN INVEST, V106, P171, DOI 10.1172/JCI10583
   Sidell RJ, 2002, DIABETES, V51, P1110, DOI 10.2337/diabetes.51.4.1110
   Stadel JM, 1997, TRENDS PHARMACOL SCI, V18, P430, DOI 10.1016/S0165-6147(97)01117-6
   Stanhope KL, 2009, J NUTR, V139, pS1236, DOI 10.3945/jn.109.106641
   Thomas R Croft, 2016, JACC Basic Transl Sci, V1, P155
   Tovar AR, 2005, J LIPID RES, V46, P1823, DOI 10.1194/jlr.M500067-JLR200
   Tran LT, 2009, MOL CELL BIOCHEM, V325, P89, DOI 10.1007/s11010-008-0023-z
   Uhlenbrock K, 2002, CELL SIGNAL, V14, P941, DOI 10.1016/S0898-6568(02)00041-4
   Wang J, 2016, BMC CANCER, V16, DOI 10.1186/s12885-016-2291-4
   Wittenberger T, 2002, BMC GENOMICS, V3, DOI 10.1186/1471-2164-3-17
   Yasuda S, 2014, J RECEPT SIG TRANSD, V34, P307, DOI 10.3109/10799893.2014.885050
   Zhang JV, 2005, SCIENCE, V310, P996, DOI 10.1126/science.1117255
   Zhou DL, 2014, J DIABETES RES, V2014, DOI 10.1155/2014/569435
   Zimmet P, 2001, NATURE, V414, P782, DOI 10.1038/414782a
NR 78
TC 9
Z9 9
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1079-9893
EI 1532-4281
J9 J RECEPT SIG TRANSD
JI J. Recept. Signal Transduct.
PY 2017
VL 37
IS 4
BP 422
EP 429
DI 10.1080/10799893.2017.1298133
PG 8
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA EW3OP
UT WOS:000402409400013
PM 28270014
DA 2025-06-11
ER

PT J
AU Venturini, D
   Simao, ANC
   Dichi, I
AF Venturini, Danielle
   Colado Simao, Andrea Name
   Dichi, Isaias
TI Advanced oxidation protein products are more related to metabolic
   syndrome components than biomarkers of lipid peroxidation
SO NUTRITION RESEARCH
LA English
DT Article
DE Metabolic syndrome; Oxidative stress; Protein oxidation; Lipid
   peroxidation; Antioxidant defenses
ID TYPE-2 DIABETES-MELLITUS; C-REACTIVE PROTEIN; INSULIN-RESISTANCE;
   URIC-ACID; WAIST CIRCUMFERENCE; RISK-FACTORS; STRESS; ASSOCIATION;
   MANAGEMENT; STATEMENT
AB Although advanced oxidation protein products (AOPPs) have been reported as the most appropriate parameter for determination of oxidative stress in patients with metabolic syndrome (MetS), a direct comparison between protein and lipid peroxidation has not been performed yet. The aim of this study was to compare protein peroxidation with lipid peroxidation measured by 2 different methodologies (tert-butyl hydroperoxide-initiated chemiluminescence and ferrous oxidation-xylenol orange assay). The hypothesis of this study was that AOPPs would be more related to MetS than to oxidative markers of lipid peroxidation. This cross-sectional study evaluated 76 patients with MetS and 20 healthy subjects. Prooxidant-antioxidant index (PAI) assessed as AOPP/total radical-trapping antioxidant parameter ratio progressively increased (P<.05) according to the number of MetS components, whereas AOPPs and total radical-trapping antioxidant parameter increased (P<.05) when 5 components were compared with 3 components. Spearman test showed a positive correlation between AOPPs and waist circumference (r = 0.318, P<.01), fasting glucose (r = 0.250, P<.05), homeostasis model assessment insulin resistance (r = 0.043, P<.01), triacylglycerol (r = 0.713, P<.0001), highly sensitive C-reactive protein (r = 0.275, P<.05), and uric acid (r = 0.356, P<.01), whereas there was an inverse correlation with high-density lipoprotein cholesterol (r = -0.399, P<.001). Prooxidant-antioxidant index demonstrated a positive correlation with waist circumference (r = 0.386, P<.01), fasting glucose (r = 0.388, P<.01), fasting insulin (r = 0.344, P<.05), homeostasis model assessment insulin resistance (r = 0.519, P<.001), triacylglycerol (r = 0.687, P<.0001), highly sensitive C-reactive protein (r = 0.278, P<.05), and uric acid (r = 0.557, P<.0001), whereas there was an inverse correlation with high-density lipoprotein cholesterol (r = -0.480, P<.0001). In conclusion, protein peroxidation determined by AOPPs, and especially by PAL is more related to MetS components than lipid peroxidation. In addition, PAI progressively increased with the number of MetS components. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Venturini, Danielle; Colado Simao, Andrea Name] Univ Londrina, Dept Pathol Clin Anal & Toxicol, BR-86038440 Londrina, Parana, Brazil.
   [Dichi, Isaias] Univ Londrina, Dept Internal Med, BR-86038440 Londrina, Parana, Brazil.
RP Simao, ANC (corresponding author), Univ Londrina, Dept Clin Pathol, Robert Koch Ave 60 Bairro Cervejaria, BR-86038440 Londrina, Parana, Brazil.
EM deianame@yahoo.com.br
RI Venturini, Danielle/HPH-1330-2023; Simão, Andrea/AAM-4892-2021
FU Research Funds of University of Londrina (FAEPE)
FX This study was financially supported by Research Funds of University of
   Londrina (FAEPE). The authors' responsibilities were as follows: D.V.
   and A.N.C.S. collected the data, designed the study, interpreted the
   results, wrote the manuscript, and performed the statistical analysis.
   I.D. developed the hypothesis tested in the study, designed the study,
   interpreted the results, and wrote the manuscript.
CR Atabek ME, 2006, EUR J PEDIATR, V165, P753, DOI 10.1007/s00431-006-0165-5
   Çakatay U, 2005, DIABETES METAB, V31, P551, DOI 10.1016/S1262-3636(07)70230-6
   Simao ANC, 2008, NUTRITION, V24, P675, DOI 10.1016/j.nut.2008.03.021
   Simáo ANC, 2012, EXPERT OPIN THER TAR, V16, P1175, DOI 10.1517/14728222.2012.723694
   Simao TNC, 2013, BRIT J NUTR, V110, P1885, DOI 10.1017/S0007114513001207
   Dichi I, 2012, EXPERT OPIN THER TAR, V16, P147, DOI 10.1517/14728222.2012.648924
   FLECHA BG, 1991, FREE RADICAL BIO MED, V10, P93
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Guevara I, 1998, CLIN CHIM ACTA, V274, P177, DOI 10.1016/S0009-8981(98)00060-6
   Haffner SM, 2003, AM J CARDIOL, V92, p18J, DOI 10.1016/S0002-9149(03)00612-X
   Kalousová M, 2002, PHYSIOL RES, V51, P597, DOI 10.33549/physiolres.930234
   Klein S, 2007, AM J CLIN NUTR, V85, P1197, DOI 10.1093/ajcn/85.5.1197
   Koçak H, 2007, CLIN EXP MED, V7, P173, DOI 10.1007/s10238-007-0143-x
   Korkmaz GG, 2013, METABOLISM, V62, P828, DOI 10.1016/j.metabol.2013.01.002
   Krzystek-Korpacka M, 2008, CLIN BIOCHEM, V41, P943, DOI 10.1016/j.clinbiochem.2008.04.024
   Yubero-Serrano EM, 2013, EXP MOL MED, V45, DOI 10.1038/emm.2013.53
   Martín-Gallán P, 2003, FREE RADICAL BIO MED, V34, P1563, DOI 10.1016/S0891-5849(03)00185-0
   Muscelli E, 1996, AM J HYPERTENS, V9, P746, DOI 10.1016/0895-7061(96)00098-2
   NOUROOZZADEH J, 1994, ANAL BIOCHEM, V220, P403, DOI 10.1006/abio.1994.1357
   Piwowar A, 2007, DIABETES RES CLIN PR, V77, P188, DOI 10.1016/j.diabres.2006.12.007
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Repetto M, 1996, CLIN CHIM ACTA, V255, P107, DOI 10.1016/0009-8981(96)06394-2
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   Sebeková K, 2006, MOL NUTR FOOD RES, V50, P858, DOI 10.1002/mnfr.200500170
   Simao ANC, 2014, OXIDATIVE STRESS CHR, P246
   Venturini D, 2012, OBESITY, V20, P2361, DOI 10.1038/oby.2012.130
   Wahrenberg H, 2005, BRIT MED J, V330, P1363, DOI 10.1136/bmj.38429.473310.AE
   WitkoSarsat V, 1996, KIDNEY INT, V49, P1304, DOI 10.1038/ki.1996.186
   Zhou QG, 2010, CELL PHYSIOL BIOCHEM, V26, P775, DOI 10.1159/000322345
   Zhou QG, 2010, J CELL PHYSIOL, V225, P42, DOI 10.1002/jcp.22189
   Zurawska-Plaksej E, 2014, J ENDOCRINOL INVEST, V37, P819, DOI 10.1007/s40618-014-0111-8
NR 33
TC 25
Z9 26
U1 0
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD SEP
PY 2015
VL 35
IS 9
BP 759
EP 765
DI 10.1016/j.nutres.2015.06.013
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CR5XE
UT WOS:000361416900002
PM 26255193
OA Bronze
DA 2025-06-11
ER

PT J
AU Han, X
   Wang, ZC
   Wang, J
   Li, YR
   Hu, H
   Hu, YJ
   Zhao, XY
   Zhan, Y
   Yuan, J
   Wei, S
   Liang, Y
   Zhang, XM
   Guo, H
   Yang, HD
   Wu, TC
   Kong, WJ
   He, MA
AF Han, Xu
   Wang, Zhichao
   Wang, Jing
   Li, Yaru
   Hu, Hua
   Hu, Yujuan
   Zhao, Xueyan
   Zhan, Yue
   Yuan, Jing
   Wei, Sheng
   Liang, Yuan
   Zhang, Xiaomin
   Guo, Huan
   Yang, Handong
   Wu, Tangchun
   Kong, Weijia
   He, Meian
TI Metabolic syndrome is associated with hearing loss among a middle-aged
   and older Chinese population: a cross-sectional study
SO ANNALS OF MEDICINE
LA English
DT Article
DE Central obesity; hearing loss; hyperglycemia; metabolic syndrome
ID NUTRITION EXAMINATION SURVEY; PLASMA ADIPONECTIN LEVELS; COCHLEAR
   FUNCTION; OXIDATIVE STRESS; NATIONAL-HEALTH; NITRIC-OXIDE; RISK-FACTORS;
   PREVALENCE; ADULTS; IMPAIRMENT
AB Background: Although the association of metabolic syndrome (MetS) and hearing loss has been evaluated, findings are controversial. This study investigated this association in a Chinese population.Methods: A cross-sectional study including a total of 18,824 middle-aged and older participants from the Dongfeng-Tongji Cohort study was conducted. Hearing loss was defined as the pure-tone average (PTA) of frequencies 0.5, 1.0, 2.0, and 4.0kHz>25 decibels hearing level (dB HL) in the better ear and graded as mild (PTA 26-40dB HL), moderate (PTA>40 to60dB HL), and severe (PTA>60dB HL). MetS was defined according to the International Diabetes Foundation (IDF) criteria of 2005. Association analysis was performed by logistic regression.Results: After adjustment for potential confounders, participants with MetS showed higher OR of hearing loss (OR, 1.11; 95% CI: 1.03-1.19). The MetS components including central obesity (OR, 1.07; 95% CI: 1.01-1.15) and hyperglycemia (OR, 1.12; 95% CI: 1.04-1.20) were also positively associated with hearing loss. Low HDL-C levels were also associated with higher OR of moderate/severe hearing loss (OR, 1.21; 95% CI: 1.07-1.36).Conclusions: The MetS, including its components central obesity, hyperglycemia, and low HDL-C levels were positively associated with hearing loss.
C1 [Han, Xu; Wang, Jing; Li, Yaru; Hu, Hua; Yuan, Jing; Wei, Sheng; Liang, Yuan; Zhang, Xiaomin; Guo, Huan; Wu, Tangchun; He, Meian] Huazhong Univ Sci & Technol, Sch Publ Hlth, Inst Occupat Med, Wuhan, Hubei, Peoples R China.
   [Han, Xu; Wang, Jing; Li, Yaru; Hu, Hua; Yuan, Jing; Wei, Sheng; Liang, Yuan; Zhang, Xiaomin; Guo, Huan; Wu, Tangchun; He, Meian] Huazhong Univ Sci & Technol, Sch Publ Hlth, Minist Educ, Key Lab Environm & Hlth, Wuhan, Hubei, Peoples R China.
   [Wang, Zhichao; Hu, Yujuan; Zhao, Xueyan; Zhan, Yue; Kong, Weijia] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Otorhinolaryngol, Wuhan, Hubei, Peoples R China.
   [Yang, Handong] Dongfeng Motor Corp, Dongfeng Cent Hosp, Shiyan, Hubei, Peoples R China.
   [Yang, Handong] Hubei Univ Med, Shiyan, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Ministry of Education -
   China; Huazhong University of Science & Technology; Huazhong University
   of Science & Technology; Dongfeng Motor; Hubei University of Medicine
RP He, MA (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, MOE Key Lab Environm & Hlth, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China.
EM hemeian@hotmail.com
RI wang, jing/GVT-8700-2022; Wang, Chenwei/HCI-8930-2022; zhao,
   xueyan/I-9434-2012; yu, ye/KVB-7532-2024; wei, sheng/E-9746-2012
OI Wang, Jing/0000-0003-4869-7719
FU National Natural Science Foundation [NSFC-81522040, 81230021, 81473051];
   National Key R&D Program of China [2017YFC0907501]; 111 Project
   [B12004]; Program for Changjiang Scholars; Innovative Research Team in
   University of Ministry of Education of China [IRT1246]; China Medical
   Board [12-113]; Program for HUST Academic Frontier Youth Team
FX This work was supported by the grant from the National Natural Science
   Foundation [Grants NSFC-81522040, 81230021, and 81473051]; National Key
   R&D Program of China [2017YFC0907501], the Program for HUST Academic
   Frontier Youth Team, the 111 Project (No. B12004); the Program for
   Changjiang Scholars; Innovative Research Team in University of Ministry
   of Education of China (No. IRT1246); and China Medical Board (No.
   12-113).
CR Agrawal Y, 2008, ARCH INTERN MED, V168, P1522, DOI 10.1001/archinte.168.14.1522
   Ahima RS, 2006, OBESITY, V14, P242, DOI 10.1038/oby.2006.317
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Bainbridge KE, 2008, ANN INTERN MED, V149, P1, DOI 10.7326/0003-4819-149-1-200807010-00231
   Beltrán-Sánchez H, 2013, J AM COLL CARDIOL, V62, P697, DOI 10.1016/j.jacc.2013.05.064
   BRECHTELSBAUER PB, 1994, HEARING RES, V77, P38, DOI 10.1016/0378-5955(94)90251-8
   Ceriello A, 2001, DIABETOLOGIA, V44, P834
   Chien CY, 2015, OTOLARYNG HEAD NECK, V153, P105, DOI 10.1177/0194599815575713
   Ciulla TA, 2003, DIABETES CARE, V26, P2653, DOI 10.2337/diacare.26.9.2653
   Cruickshanks KJ, 2015, J AM GERIATR SOC, V63, P918, DOI 10.1111/jgs.13401
   CULLEN JR, 1993, J LARYNGOL OTOL, V107, P179, DOI 10.1017/S0022215100122571
   Dalton DS, 2003, GERONTOLOGIST, V43, P661, DOI 10.1093/geront/43.5.661
   Dalton DS, 1998, DIABETES CARE, V21, P1540, DOI 10.2337/diacare.21.9.1540
   Evans MB, 2006, OTOL NEUROTOL, V27, P609, DOI 10.1097/01.mao.0000226286.19295.34
   Fechter LD, 2003, TOXICOL SCI, V75, P117, DOI 10.1093/toxsci/kfg169
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   Fox CS, 2005, DIABETES CARE, V28, P2436, DOI 10.2337/diacare.28.10.2436
   Fujimoto C, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/582849
   Fukushima H, 2005, OTOLARYNG HEAD NECK, V133, P100, DOI 10.1016/j.otohns.2005.02.004
   GATES GA, 1993, ARCH OTOLARYNGOL, V119, P156
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Heinrich UR, 2012, NITRIC OXIDE-BIOL CH, V27, P106, DOI 10.1016/j.niox.2012.05.005
   Henderson D, 2006, EAR HEARING, V27, P1, DOI 10.1097/01.aud.0000191942.36672.f3
   Hu X Y, 2016, Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, V51, P819, DOI 10.3760/cma.j.issn.1673-0860.2016.11.004
   Huang KC, 2004, OBES RES, V12, P119, DOI 10.1038/oby.2004.16
   Hwang JH, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0060730
   Ikuno Y, 2005, AM J OPHTHALMOL, V139, P462, DOI 10.1016/j.ajo.2004.09.078
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Kaygusuz I, 2001, HEARING RES, V162, P43, DOI 10.1016/S0378-5955(01)00365-3
   Lalwani AK, 2013, LARYNGOSCOPE, V123, P3178, DOI 10.1002/lary.24244
   Li XY, 2015, ACTA OTO-LARYNGOL, V135, P536, DOI 10.3109/00016489.2014.995830
   Loffredo L, 2012, J PEDIATR-US, V161, P1004, DOI 10.1016/j.jpeds.2012.05.042
   Lüscher TF, 2014, CIRC RES, V114, P171, DOI 10.1161/CIRCRESAHA.114.300935
   Ma FC, 1998, J LARYNGOL OTOL, V112, P835, DOI 10.1017/S0022215100141842
   Michikawa T, 2014, J AM GERIATR SOC, V62, P1231, DOI 10.1111/jgs.12906
   Mitchell P, 2009, DIABETIC MED, V26, P483, DOI 10.1111/j.1464-5491.2009.02710.x
   Oh IH, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0116161
   Pleis John R, 2006, Vital Health Stat 10, P1
   Shargorodsky J, 2010, LARYNGOSCOPE, V120, P1887, DOI 10.1002/lary.21039
   Strawbridge WJ, 1996, AM J EPIDEMIOL, V144, P135, DOI 10.1093/oxfordjournals.aje.a008900
   Sun YS, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0134388
   Suzuki K, 2000, LARYNGOSCOPE, V110, P1736, DOI 10.1097/00005537-200010000-00033
   Trevisan M, 1998, AM J EPIDEMIOL, V148, P958
   VandenLangenberg GM, 1998, AM J EPIDEMIOL, V148, P204, DOI 10.1093/oxfordjournals.aje.a009625
   Verschuur CA, 2012, AGE AGEING, V41, P92, DOI 10.1093/ageing/afr140
   Wang F, 2013, INT J EPIDEMIOL, V42, P731, DOI 10.1093/ije/dys053
   Xi B, 2013, PREV MED, V57, P867, DOI 10.1016/j.ypmed.2013.09.023
   Yamasoba T, 2005, NEUROSCI LETT, V380, P234, DOI 10.1016/j.neulet.2005.01.047
   Yang WS, 2002, OBES RES, V10, P1104, DOI 10.1038/oby.2002.150
   Zhou BF, 2002, BIOMED ENVIRON SCI, V15, P83
NR 50
TC 23
Z9 25
U1 0
U2 16
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PY 2018
VL 50
IS 7
BP 587
EP 595
DI 10.1080/07853890.2018.1469786
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA HL2TK
UT WOS:000458559600006
PM 29693425
OA Bronze
DA 2025-06-11
ER

PT J
AU Nagasawa, N
   Tamakoshi, K
   Yatsuya, H
   Hori, Y
   Ishikawa, M
   Murata, C
   Zhang, HM
   Wada, K
   Otsuka, R
   Mabuchi, T
   Kondo, T
   Toyoshima, H
AF Nagasawa, N
   Tamakoshi, K
   Yatsuya, H
   Hori, Y
   Ishikawa, M
   Murata, C
   Zhang, HM
   Wada, K
   Otsuka, R
   Mabuchi, T
   Kondo, T
   Toyoshima, H
TI Association of white blood cell count and clustered components of
   metabolic syndrome in Japanese men
SO CIRCULATION JOURNAL
LA English
DT Article
DE cardiovascular disease risk factor; Japanese men; low-grade
   inflammation; metabolic syndrome; white blood cell
ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA;
   LEUKOCYTE COUNT; CARDIOVASCULAR-DISEASE; RISK-FACTORS; ATHEROSCLEROSIS
   RISK; INSULIN-RESISTANCE; OXIDATIVE STRESS; INFLAMMATION
AB Background The role of inflammation in the genesis of cardiovascular disease has attracted attention and in the present study the association among metabolic syndrome (MS), white blood cell (WBC) count, and insulin concentration was investigated.
   Methods and Results A cross-sectional study of 3,594 Japanese men aged 34-69 years evaluated the MS components (high blood pressure, hypo-high density lipoprotein (HDL)-cholesterolemia, hypertriglyceridemia, hyperglycemia), as defined by the criteria given in the Third Report of the National Cholesterol Education Program Expert Panel on Detection Evaluation, and Treatment of High Blood Cholesterol in Adults, except for obesity [body mass index (BMI) greater than or equal to25 kg/m(2)]. WBC count had a positive correlation with BMI, blood pressure, triglyceride, glucose and insulin, and a negative correlation with HDL-cholesterol. The multi-adjusted means of WBC count and insulin concentration were significantly higher in MS subjects defined as having 3 or more of the components than in non-MS subjects with no more than 2 components. Both means also increased with the number of MS components (p<0.001 for trend). In the multiple linear regression analysis, BMI, HDL-cholesterol, systolic blood pressure, glucose and triglyceride had a significant and independent association with WBC count, but the insulin concentration did not.
   Conclusions The cluster of MS components based on insulin resistance may cause low-grade inflammation.
C1 Nagoya Univ, Grad Sch Med,Field Social Life Sci, Dept Publ Hlth Hlth Informat Dynam, Program Hlth & Community Med, Nagoya, Aichi 4668550, Japan.
   Nagoya Univ, Sch Hlth Sci, Dept Med Technol, Nagoya, Aichi 4668550, Japan.
C3 Nagoya University; Nagoya University
RP Nagoya Univ, Grad Sch Med, Dept Publ Hlth, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan.
EM toyosima@med.nagoya-u.ac.jp
RI Yatsuya, Hiroshi/L-4213-2016
CR Brown DW, 2001, J CLIN EPIDEMIOL, V54, P316, DOI 10.1016/S0895-4356(00)00296-1
   Choi H, 2004, CIRC J, V68, P297, DOI 10.1253/circj.68.297
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   DEFRONZO RA, 1991, DIABETES CARE, V14, P173, DOI 10.2337/diacare.14.3.173
   FERRANNINI E, 1991, DIABETOLOGIA, V34, P416, DOI 10.1007/BF00403180
   Ford ES, 2003, ATHEROSCLEROSIS, V168, P351, DOI 10.1016/S0021-9150(03)00134-5
   FRIEDMAN GD, 1990, J CLIN EPIDEMIOL, V43, P907, DOI 10.1016/0895-4356(90)90074-Y
   FRIEDMAN GD, 1974, NEW ENGL J MED, V290, P1275, DOI 10.1056/NEJM197406062902302
   FRIEDMAN GD, 1990, INT J EPIDEMIOL, V19, P889, DOI 10.1093/ije/19.4.889
   Gray RS, 1998, AM J EPIDEMIOL, V148, P869
   HANSEN LK, 1990, INT J EPIDEMIOL, V19, P881, DOI 10.1093/ije/19.4.881
   HANSSON GK, 1993, BRIT HEART J, V69, pS38
   HOTAMISLIGIL GS, 1995, J CLIN INVEST, V95, P2409, DOI 10.1172/JCI117936
   Huang ZS, 2001, LIPIDS, V36, P237, DOI 10.1007/s11745-001-0713-9
   Ichihara Y, 2002, CIRC J, V66, P677, DOI 10.1253/circj.66.677
   KANNEL WB, 1992, JAMA-J AM MED ASSOC, V267, P1253, DOI 10.1001/jama.267.9.1253
   Koenig W, 1999, CIRCULATION, V99, P237, DOI 10.1161/01.CIR.99.2.237
   KOSTIS JB, 1984, AM J CARDIOL, V53, P997, DOI 10.1016/0002-9149(84)90624-6
   Lee CD, 2001, AM J EPIDEMIOL, V154, P758, DOI 10.1093/aje/154.8.758
   Matsuzawa Y, 2002, CIRC J, V66, P987, DOI 10.1253/circj.66.987
   Mohamed-Ali V, 1997, J CLIN ENDOCR METAB, V82, P4196, DOI 10.1210/jc.82.12.4196
   Nakanishi N, 2002, J HYPERTENS, V20, P851, DOI 10.1097/00004872-200205000-00018
   Nakanishi N, 2002, OCCUP MED-OXFORD, V52, P213, DOI 10.1093/occmed/52.4.213
   NIELSON CP, 1989, DIABETES, V38, P1031, DOI 10.2337/diabetes.38.8.1031
   NIETO FJ, 1992, AM J EPIDEMIOL, V136, P525, DOI 10.1093/oxfordjournals.aje.a116530
   Pearson TA, 2003, CIRCULATION, V107, P499, DOI 10.1161/01.CIR.0000052939.59093.45
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Sabatine MS, 2002, J AM COLL CARDIOL, V40, P1761, DOI 10.1016/S0735-1097(02)02484-1
   Schmidt MI, 1999, LANCET, V353, P1649, DOI 10.1016/S0140-6736(99)01046-6
   Shurtz-Swirski R, 2001, DIABETES CARE, V24, P104, DOI 10.2337/diacare.24.1.104
   Sim E., 1993, Humoral Factors
   Solymoss BC, 2004, AM J CARDIOL, V93, P159, DOI 10.1016/j.amjcard.2003.09.032
   *SPSS INC, 2001, 2001 SPSS BAS 11 0J
   Tamakoshi K, 2003, INT J OBESITY, V27, P443, DOI 10.1038/sj.ijo.0802260
   Targher G, 1996, J INTERN MED, V239, P435, DOI 10.1046/j.1365-2796.1996.815000.x
   Weijenberg MP, 1996, ARTERIOSCL THROM VAS, V16, P499, DOI 10.1161/01.ATV.16.4.499
   YARNELL JWG, 1991, CIRCULATION, V83, P836, DOI 10.1161/01.CIR.83.3.836
   Yasunari K, 2002, HYPERTENSION, V39, P777, DOI 10.1161/hy0302.104670
NR 38
TC 76
Z9 83
U1 0
U2 6
PU JAPANESE CIRCULATION SOC
PI TOYKO
PA 18TH FLOOR IMPERIAL HOTEL TOWER, 1-1-1 UCHISAIWAI-CHO CHIYODA-KU, TOYKO,
   100-0011, JAPAN
SN 1346-9843
EI 1347-4820
J9 CIRC J
JI Circ. J.
PD OCT
PY 2004
VL 68
IS 10
BP 892
EP 897
DI 10.1253/circj.68.892
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 857VH
UT WOS:000224146600002
PM 15459460
OA Bronze
DA 2025-06-11
ER

PT J
AU Vancampfort, D
   De Hert, M
   Skjerven, LH
   Gyllensten, AL
   Parker, A
   Mulders, N
   Nyboe, L
   Spencer, F
   Probst, M
AF Vancampfort, Davy
   De Hert, Marc
   Skjerven, Liv Helvik
   Gyllensten, Amanda Lundvik
   Parker, Anne
   Mulders, Nathalie
   Nyboe, Lene
   Spencer, Felicity
   Probst, Michel
TI International Organization of Physical Therapy in Mental Health
   consensus on physical activity within multidisciplinary rehabilitation
   programmes for minimising cardio-metabolic risk in patients with
   schizophrenia
SO DISABILITY AND REHABILITATION
LA English
DT Review
DE Physical activity; physiotherapy; schizophrenia; guidelines
ID ATYPICAL ANTIPSYCHOTICS; CARDIOMETABOLIC RISK; PSYCHOTIC DISORDERS;
   CARDIOVASCULAR RISK; GUIDELINES; BARRIERS; EXERCISE; ILLNESS; HABITS;
   PEOPLE
AB Purpose: The excess cardiovascular morbidity associated with schizophrenia is attributed to an interplay between behavioural (physical inactivity, unhealthy diet, substance abuse), genetic and illness related factors, as well as the effects of antipsychotic treatment. Patients have limited access to physical healthcare with less opportunity for cardiovascular risk prevention and treatment programmes than the non-psychiatric population. The aim of this paper is to improve physical activity (PA) within rehabilitation programmes for people with schizophrenia. Method: The development process consisted of: a) systematic literature review on PA in schizophrenia in eight databases up to May 2010; b) review on existing national and international guidelines; c) consensus meetings, and d) formulation of the final consensus document. Results: There is insufficient evidence for the relative contribution of PA reducing cardio-metabolic risks in people with schizophrenia. Demographical, biological, psychological, cognitive-behavioural, emotional, social and environmental barriers for PA could be identified. Conclusions: Although PA outcomes on cardio-metabolic parameters are still unknown, the benefits of physical activity as part of a larger lifestyle programme are sufficient for the recommendation that persons with schizophrenia follow the 2008 U. S. Department of Health and Human Services PA Guidelines with specific adaptations based on disease and treatment-related adverse effects.
C1 [Vancampfort, Davy; De Hert, Marc; Probst, Michel] Katholieke Univ Leuven, Univ Psychiat Ctr, Kortenberg, Belgium.
   [Skjerven, Liv Helvik] Bergen Univ Coll, Fac Hlth & Sci, Dept Physiotherapy, Bergen, Norway.
   [Gyllensten, Amanda Lundvik] Lund Univ, Dept Hlth Sci, Div Physiotherapy, Lund, Sweden.
   [Parker, Anne] Royal Edinburgh & Associated Hosp, Edinburgh, Midlothian, Scotland.
   [Nyboe, Lene] Aarhus Univ Hosp, Ctr Psychiat Res, Risskov, Denmark.
   [Spencer, Felicity] Sydney Childrens Hosp, Sydney, NSW, Australia.
C3 KU Leuven; Western Norway University of Applied Sciences; Lund
   University; Royal Infirmary of Edinburgh; Aarhus University; University
   of Sydney; NSW Health; Sydney Childrens Hospitals Network
RP Vancampfort, D (corresponding author), Katholieke Univ Leuven, Univ Psychiat Ctr, Campus Kortenberg, Kortenberg, Belgium.
EM Davy.Vancampfort@uc-kortenberg.be
RI Probst, Michel/ABE-6137-2020; De Hert, Marc/AAH-6090-2021; Vancampfort,
   Davy/AAD-1987-2019
OI De Hert, Marc/0000-0003-4255-5920; Lundvik Gyllensten,
   Amanda/0000-0001-6289-9347; Nyboe, Lene/0000-0001-7131-3010
FU AstraZeneca; Lundbeck JA; Janssen-Cilag; Eli Lilly; Pfizer; Sanofi;
   Bristol-Myers Squibb
FX The Lund IOPTMH conference and Copenhagen board meeting were not
   supported by any sponsor. The organisers specifically excluded
   pharmaceutical industry employees in the conference consensus meeting on
   schizophrenia. In addition, all contributors disclosed potential
   conflicts of interest. Dr. M De Hert has been a consultant for, received
   grant/research support and honoraria from, and been on the
   speakers/advisory boards of AstraZeneca, Lundbeck JA, Janssen-Cilag, Eli
   Lilly, Pfizer, Sanofi and Bristol-Myers Squibb. The other authors
   declare that they have no conflicts of interest. The authors alone are
   responsible for the content and writing of the paper.
CR Allison DB, 2009, AM J PREV MED, V36, P341, DOI 10.1016/j.amepre.2008.11.020
   Amer Diabet Assoc, 2004, DIABETES CARE, V27, P596, DOI 10.2337/diacare.27.2.596
   [Anonymous], EUR J CARDIOVASC PRE
   [Anonymous], 2008, PHYS ACT GUID AM
   [Anonymous], IJTR
   [Anonymous], 2022, Circulation
   [Anonymous], J MENT HLTH PROM
   [Anonymous], 2000, DIAGN STAT MAN MENT
   Archie S, 2003, CAN J PSYCHIAT, V48, P628, DOI 10.1177/070674370304800910
   Archie SM, 2007, PSYCHIAT SERV, V58, P233, DOI 10.1176/appi.ps.58.2.233
   Barnett AH, 2007, J PSYCHOPHARMACOL, V21, P357, DOI 10.1177/0269881107075509
   Beebe Lora Humphrey, 2005, Issues Ment Health Nurs, V26, P661
   Bobes J, 2010, SCHIZOPHR RES, V119, P101, DOI 10.1016/j.schres.2010.02.1030
   Carter-Morris P., 2003, Journal of Mental Health Promotion, V2, P24
   De Hert M, 2011, BRIT J PSYCHIAT, V199, P99, DOI 10.1192/bjp.bp.110.084665
   De Hert M, 2009, EUR PSYCHIAT, V24, P412, DOI 10.1016/j.eurpsy.2009.01.005
   De Hert M, 2008, SCHIZOPHR RES, V101, P295, DOI 10.1016/j.schres.2008.01.028
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P138
   De Hert M, 2009, WORLD PSYCHIATRY, V8, P15
   de Nayer A, 2007, ENCEPHALE, V33, P197
   Dinan TG, 2004, BRIT J PSYCHIAT, V184, pS53, DOI 10.1192/bjp.184.47.s53
   Duraiswamy G, 2007, ACTA PSYCHIAT SCAND, V116, P226, DOI 10.1111/j.1600-0447.2007.01032.x
   Eden KB, 2002, ANN INTERN MED, V137, P208, DOI 10.7326/0003-4819-137-3-200208060-00015
   Fagiolini A, 2009, J CLIN PSYCHIAT, V70, P22, DOI 10.4088/JCP.7075su1c.04
   Faulkner G, 2007, PATIENT EDUC COUNS, V66, P123, DOI 10.1016/j.pec.2006.11.003
   Fleischhacker WW, 2008, J CLIN PSYCHIAT, V69, P514, DOI 10.4088/JCP.v69n0401
   Fogarty M, 2004, PSYCHIATR REHABIL J, V28, P173, DOI 10.2975/28.2004.173.176
   Gothefors D, 2010, NORD J PSYCHIAT, V64, P294, DOI 10.3109/08039488.2010.500397
   Hart C., 2001, DOING LIT SEARCH COM
   Heiskanen T, 2003, J CLIN PSYCHIAT, V64, P575, DOI 10.4088/JCP.v64n0513
   Hennekens CH, 2005, AM HEART J, V150, P1115, DOI 10.1016/j.ahj.2005.02.007
   Johnstone R, 2009, J MENT HEALTH, V18, P523, DOI 10.3109/09638230903111114
   Kilbourne AM, 2009, GEN HOSP PSYCHIAT, V31, P555, DOI 10.1016/j.genhosppsych.2009.07.008
   Lambert TJR, 2004, MED J AUSTRALIA, V181, P544, DOI 10.5694/j.1326-5377.2004.tb06443.x
   Laursen TM, 2007, J CLIN PSYCHIAT, V68, P899, DOI 10.4088/JCP.v68n0612
   Leucht S, 2007, ACTA PSYCHIAT SCAND, V116, P317, DOI 10.1111/j.1600-0447.2007.01095.x
   Lindamer LA, 2008, SCHIZOPHR RES, V104, P294, DOI 10.1016/j.schres.2008.04.040
   Marder SR, 2004, AM J PSYCHIAT, V161, P1334, DOI 10.1176/appi.ajp.161.8.1334
   Marzolini S., 2009, MENT HEALTH PHYS ACT, V2, P29, DOI 10.1016/j.mhpa.2008.11.001
   McDevitt J, 2006, J NURS SCHOLARSHIP, V38, P50, DOI 10.1111/j.1547-5069.2006.00077.x
   McGrath J, 2008, EPIDEMIOL REV, V30, P67, DOI 10.1093/epirev/mxn001
   Medalia A, 2010, SCHIZOPHRENIA BULL, V36, P912, DOI 10.1093/schbul/sbq073
   Melkersson KI, 2004, PSYCHOPHARMACOLOGY, V175, P1, DOI 10.1007/s00213-004-1922-7
   Mulder H, 2009, J CLIN PSYCHOPHARM, V29, P16, DOI 10.1097/JCP.0b013e3181934462
   Pedersen BK, 2006, SCAND J MED SCI SPOR, V16, P3, DOI 10.1111/j.1600-0838.2006.00520.x
   Poulin MJ, 2005, CAN J PSYCHIAT, V50, P555, DOI 10.1177/070674370505000909
   Priebe S, 2001, PSYCHIAT RES, V101, P289, DOI 10.1016/S0165-1781(01)00214-1
   Probst M., 2010, Open Compl. Med. J., V2, P105, DOI 10.2174/1876391X010020010105
   Putzhammer A, 2004, SCHIZOPHR RES, V69, P159, DOI 10.1016/S0920-9964(03)00090-2
   Richardson CR, 2005, PSYCHIAT SERV, V56, P324, DOI 10.1176/appi.ps.56.3.324
   Roick C, 2007, SOC PSYCH PSYCH EPID, V42, P268, DOI 10.1007/s00127-007-0164-5
   Ross R, 2009, BRIT J SPORT MED, V43, P57, DOI 10.1136/bjsm.2008.053504
   Rössler W, 2005, EUR NEUROPSYCHOPHARM, V15, P399, DOI 10.1016/j.euroneuro.2005.04.009
   Rüsch N, 2002, PSYCHIATR REHABIL J, V26, P23, DOI 10.2975/26.2002.23.32
   Saha S, 2007, ARCH GEN PSYCHIAT, V64, P1123, DOI 10.1001/archpsyc.64.10.1123
   Ruiz JS, 2008, ACTAS ESP PSIQUIATRI, V36, P251
   Scheen AJ, 2007, DIABETES METAB, V33, P169, DOI 10.1016/j.diabet.2007.01.003
   Sorensen M, 2006, SCAND J MED SCI SPOR, V16, P391, DOI 10.1111/j.1600-0838.2005.00514.x
   Straker D, 2005, AM J PSYCHIAT, V162, P1217, DOI 10.1176/appi.ajp.162.6.1217
   Torres-Carbajo A., 2005, American Journal of Recreation Therapy, V4, P41
   Trost SG, 2002, MED SCI SPORT EXER, V34, P1996, DOI 10.1097/00005768-200212000-00020
   Usher K, 2006, J PSYCHIATR MENT HLT, V13, P730, DOI 10.1111/j.1365-2850.2006.01026.x
   Ussher M, 2007, PSYCHIAT SERV, V58, P405, DOI 10.1176/appi.ps.58.3.405
   Vancampfort D, 2009, PHYS THER REV, V14, P388, DOI 10.1179/108331909X12540993898053
   Vancampfort D, 2010, PSYCHIAT RES, V177, P271, DOI 10.1016/j.psychres.2010.03.011
   vanTulder MW, 1997, SPINE, V22, P2323, DOI 10.1097/00007632-199710150-00001
   Verhagen E, 2009, BRIT J SPORT MED, V43, P99, DOI 10.1136/bjsm.2008.053801
   ,, 2008, The global burden of disease: 2004 update
NR 68
TC 111
Z9 118
U1 0
U2 36
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-8288
EI 1464-5165
J9 DISABIL REHABIL
JI Disabil. Rehabil.
PY 2012
VL 34
IS 1
BP 1
EP 12
DI 10.3109/09638288.2011.587090
PG 12
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Rehabilitation
GA 851LV
UT WOS:000297272600001
PM 21957908
DA 2025-06-11
ER

PT J
AU Sun, SJ
   Hu, FT
   Sang, YR
   Wang, S
   Liu, XC
   Shi, JF
   Cao, HJ
   Tao, FB
   Liu, KY
AF Sun, Shujing
   Hu, Fangting
   Sang, Yanru
   Wang, Sheng
   Liu, Xuechun
   Shi, Jiafeng
   Cao, Hongjuan
   Tao, Fangbiao
   Liu, Kaiyong
TI Dysregulated tryptophan metabolism contributes to metabolic syndrome in
   Chinese community-dwelling older adults
SO BMC ENDOCRINE DISORDERS
LA English
DT Article
DE Metabolic syndrome; Tryptophan; Metabolism; Older adults
ID POPULATION; DEFINITION; PREVALENCE; PATHWAY; AGE
AB BackgroundAs the prevalence of metabolic syndrome (MetS) rises among older adults, the associated risks of cardiovascular diseases and diabetes significantly increase, and it is closely linked to various metabolic processes in the body. Dysregulation of tryptophan (TRP) metabolism, particularly alterations in the kynurenine (KYN) and serotonin pathways, has been linked to the onset of chronic inflammation, oxidative stress, and insulin resistance, key contributors to the development of MetS. We aim to investigate the relationship between the TRP metabolites and the risk of MetS in older adults. MethodsUltra-performance liquid chromatography tandem mass spectrometry was used to detect TRP and its seven metabolites in a study involving 986 participants. Physical examination included the following indicators: blood pressure, body mass index, triglyceride levels, and high-density lipoprotein cholesterol (HDL-C) levels. Multiple linear regression, restricted cubic spline curve, binary logistic analysis, and sex-stratified analysis were used to explore the relationship between the metabolites and the risk of MetS in older adults. ResultsThe results indicated that, after adjusting for covariates, higher levels of TRP, KYN, kynurenic acid (KA), and xanthurenic acid (XA) were risk factors for MetS (P for trend < 0.05). By contrast, higher ratios of 5-hydroxytryptamine to TRP and indole-3-propionic acid to TRP were protective factors against MetS (P for trend < 0.05). ConclusionsTRP and its metabolites may serve as potential indicators for assessing and managing MetS in older adults, complementing existing biomarkers. Clinical trial numberNot applicable.
C1 [Sun, Shujing; Hu, Fangting; Sang, Yanru; Shi, Jiafeng; Tao, Fangbiao; Liu, Kaiyong] Anhui Med Univ, Sch Publ Hlth, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China.
   [Wang, Sheng] Anhui Med Univ, Ctr Sci Res, Hefei 230032, Anhui, Peoples R China.
   [Liu, Xuechun] Anhui Med Univ, Hefei Hosp, Hefei Peoples Hosp 2, Hefei 230011, Anhui, Peoples R China.
   [Cao, Hongjuan] Luan Ctr Dis Control & Prevent, Luan 237000, Anhui, Peoples R China.
   [Tao, Fangbiao; Liu, Kaiyong] Inst Hlth & Med, Ctr Big Data & Populat Hlth, Hefei 230032, Anhui, Peoples R China.
C3 Anhui Medical University; Anhui Medical University; Anhui Medical
   University
RP Liu, KY (corresponding author), Anhui Med Univ, Sch Publ Hlth, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China.; Liu, KY (corresponding author), Inst Hlth & Med, Ctr Big Data & Populat Hlth, Hefei 230032, Anhui, Peoples R China.
EM liukaiyong163@163.com
RI Sun, Shujing/KHW-1325-2024
FU MOE Key Laboratory of Population Health across Life Cycle
FX The authors would like to thank all the staff and students who
   contributed to the study. They would also like to thank all the study
   participants for their support. In addition, they would like to
   sincerely thank all the members of the experimental center platform of
   Anhui Medical University.
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alexeev EE, 2018, AM J PATHOL, V188, P1183, DOI 10.1016/j.ajpath.2018.01.011
   Badawy AAB, 2016, INT J TRYPTOPHAN RES, V9, P31, DOI [10.4137/IJTR.S38189, 10.4137/ijtr.s38189]
   Bishehsari F, 2020, NAT REV ENDOCRINOL, V16, P731, DOI 10.1038/s41574-020-00427-4
   Bovolini A, 2021, INT J SPORTS MED, V42, P199, DOI 10.1055/a-1263-0898
   Buchmann N, 2019, J FRALITY AGING, V8, P169, DOI 10.14283/jfa.2019.15
   Coelho NR, 2021, PHARMACOL RES, V165, DOI 10.1016/j.phrs.2020.105407
   Delgado I, 2022, INT J OBESITY, V46, P885, DOI 10.1038/s41366-021-01049-0
   Ford ES, 2010, J DIABETES, V2, P180, DOI 10.1111/j.1753-0407.2010.00078.x
   Huang T, 2022, NAT COMMUN, V13, DOI 10.1038/s41467-022-31126-5
   Jiang CY, 2024, LIFE SCI, V358, DOI 10.1016/j.lfs.2024.123171
   Laurans L, 2018, NAT MED, V24, P1113, DOI 10.1038/s41591-018-0060-4
   Li MY, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-44819-7
   Liu XJ, 2021, ENVIRON SCI POLLUT R, V28, P26794, DOI 10.1007/s11356-021-12560-2
   Ma AJ, 2020, OBESITY FACTS, V13, P538, DOI 10.1159/000508842
   Ma YY, 2022, J ATHEROSCLER THROMB, V29, P322, DOI 10.5551/jat.58305
   Mallmann NH, 2018, METAB SYNDR RELAT D, V16, P135, DOI 10.1089/met.2017.0097
   Mangge H, 2014, OBESITY, V22, P195, DOI 10.1002/oby.20491
   Mir FA, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23179821
   Natividad JM, 2018, CELL METAB, V28, P737, DOI 10.1016/j.cmet.2018.07.001
   Nonogaki K, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23031600
   Noubiap JJ, 2022, DIABETES RES CLIN PR, V188, DOI 10.1016/j.diabres.2022.109924
   Ntzouvani A, 2017, NUTR METAB CARDIOVAS, V27, P1021, DOI 10.1016/j.numecd.2017.07.006
   Oh JS, 2017, ANAL BIOANAL CHEM, V409, P5501, DOI 10.1007/s00216-017-0486-4
   Oxenkrug Gregory, 2017, Integr Clin Med, V1, DOI 10.15761/ICM.1000105
   Oxenkrug G, 2020, MOL NEUROBIOL, V57, P135, DOI 10.1007/s12035-019-01763-x
   Oxenkrug GF, 2010, ANN NY ACAD SCI, V1199, P1, DOI 10.1111/j.1749-6632.2009.05356.x
   Pertovaara M, 2007, CLIN EXP IMMUNOL, V148, P106, DOI 10.1111/j.1365-2249.2007.03325.x
   Platten M, 2019, NAT REV DRUG DISCOV, V18, P379, DOI 10.1038/s41573-019-0016-5
   Sang YR, 2021, ECOTOX ENVIRON SAFE, V210, DOI 10.1016/j.ecoenv.2020.111863
   Sas K, 2018, MOLECULES, V23, DOI 10.3390/molecules23010191
   Stephen DS, 2019, NUTR NEUROSCI, V22, P51, DOI [10.1080/1028415x.2017.1354511, 10.1080/1028415X.2017.1354511]
   Taleb S, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.02113
   Wang DN, 2022, FREE RADICAL BIO MED, V178, P226, DOI 10.1016/j.freeradbiomed.2021.12.009
   Wang S, 2023, BIOMED CHROMATOGR, V37, DOI 10.1002/bmc.5512
   Wu L, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010228
   Xiong Y, 2021, AGING MALE, V24, P148, DOI 10.1080/13685538.2021.1998432
   Xue C, 2023, CELL METAB, V35, P1304, DOI 10.1016/j.cmet.2023.06.004
   Zhang C, 2023, BIOMED PHARMACOTHER, V165, DOI 10.1016/j.biopha.2023.115273
   Zhong XQ, 2022, GENE, V819, DOI 10.1016/j.gene.2022.146265
NR 40
TC 1
Z9 1
U1 2
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6823
J9 BMC ENDOCR DISORD
JI BMC Endocr. Disord.
PD JAN 8
PY 2025
VL 25
IS 1
AR 7
DI 10.1186/s12902-024-01826-8
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA R8W0X
UT WOS:001394169900001
PM 39780122
OA gold
DA 2025-06-11
ER

PT J
AU Lancel, S
   Montaigne, D
   Marechal, X
   Marciniak, C
   Hassoun, SM
   Decoster, B
   Ballot, C
   Blazejewski, C
   Corseaux, D
   Lescure, B
   Motterlini, R
   Neviere, R
AF Lancel, Steve
   Montaigne, David
   Marechal, Xavier
   Marciniak, Camille
   Hassoun, Sidi Mohamed
   Decoster, Brigitte
   Ballot, Caroline
   Blazejewski, Caroline
   Corseaux, Delphine
   Lescure, Bernadette
   Motterlini, Roberto
   Neviere, Remi
TI Carbon Monoxide Improves Cardiac Function and Mitochondrial Population
   Quality in a Mouse Model of Metabolic Syndrome
SO PLOS ONE
LA English
DT Article
ID IN-VIVO; OXIDATIVE STRESS; HEME OXYGENASE-1; PROTEIN-KINASE; BIOGENESIS;
   MICE; AUTOPHAGY; EXPRESSION; MOLECULE; RESPIRATION
AB Aims: Metabolic syndrome induces cardiac dysfunction associated with mitochondria abnormalities. As low levels of carbon monoxide (CO) may improve myocardial and mitochondrial activities, we tested whether a CO-releasing molecule (CORM-3) reverses metabolic syndrome-induced cardiac alteration through changes in mitochondrial biogenesis, dynamics and autophagy.
   Methods and Results: Mice were fed with normal diet (ND) or high-fat diet (HFD) for twelve weeks. Then, mice received two intraperitoneal injections of CORM-3 (10 mg.kg(-1)), with the second one given 16 hours after the first. Contractile function in isolated hearts and mitochondrial parameters were evaluated 24 hours after the last injection. Mitochondrial population was explored by electron microscopy. Changes in mitochondrial dynamics, biogenesis and autophagy were assessed by western-blot and RT-qPCR. Left ventricular developed pressure was reduced in HFD hearts. Mitochondria from HFD hearts presented reduced membrane potential and diminished ADP-coupled respiration. CORM-3 restored both cardiac and mitochondrial functions. Size and number of mitochondria increased in the HFD hearts but not in the CORM-3-treated HFD group. CORM-3 modulated HFD-activated mitochondrial fusion and biogenesis signalling. While autophagy was not activated in the HFD group, CORM-3 increased the autophagy marker LC3-II. Finally, ex vivo experiments demonstrated that autophagy inhibition by 3-methyladenine abolished the cardioprotective effects of CORM-3.
   Conclusion: CORM-3 may modulate pathways controlling mitochondrial quality, thus leading to improvements of mitochondrial efficiency and HFD-induced cardiac dysfunction.
C1 [Lancel, Steve; Montaigne, David; Marechal, Xavier; Marciniak, Camille; Hassoun, Sidi Mohamed; Decoster, Brigitte; Ballot, Caroline; Blazejewski, Caroline; Neviere, Remi] Univ Lille 2, EA4484, Dept Physiol, Lille, France.
   [Corseaux, Delphine] Univ Lille 2, EA2693, Lille, France.
   [Lescure, Bernadette] Univ Paris 06, INSERM, IFR65, Irssa, Paris, France.
   [Motterlini, Roberto] Paris Est Univ, INSERM, U955, Fac Med, Creteil, France.
C3 Universite de Lille; Universite de Lille; Institut National de la Sante
   et de la Recherche Medicale (Inserm); Sorbonne Universite; Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Institut National de la Sante et
   de la Recherche Medicale (Inserm)
RP Lancel, S (corresponding author), Univ Lille 2, EA4484, Dept Physiol, Lille, France.
EM steve.lancel@univ-lille2.fr
RI Marechal, Xavier/R-5762-2018; LANCEL, Steve/H-9047-2019; Motterlini,
   Roberto/Q-1890-2019; Motterlini, Roberto/G-2489-2013; montaigne,
   david/R-6066-2018; Corseaux, Delphine/R-4360-2018
OI Neviere, Remi/0000-0002-7966-0110; Lancel, Steve/0000-0002-3292-5433;
   Motterlini, Roberto/0000-0003-2684-2612; montaigne,
   david/0000-0002-2346-863X; Corseaux, Delphine/0000-0001-8642-1508
FU Universite Lille 2- Ministere de l'Enseignement Superieur et de la
   Recherche [EA4484]; CPER "cardiodiabete 2008'' - FEDER Region Nord
   Pas-de-Calais [08480265]; Fondation de France [2009002501]; Fondation
   Coeur et Arteres [FCA09T6]
FX This work was supported by EA4484- Universite Lille 2- Ministere de
   l'Enseignement Superieur et de la Recherche; CPER "cardiodiabete 2008''
   - FEDER Region Nord Pas-de-Calais 08480265; Fondation de France
   2009002501 and Fondation Coeur et Arteres FCA09T6. The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
CR Andre L, 2010, AM J RESP CRIT CARE, V181, P587, DOI 10.1164/rccm.200905-0794OC
   Boudina S, 2007, DIABETES, V56, P2457, DOI 10.2337/db07-0481
   Boudina S, 2010, REV ENDOCR METAB DIS, V11, P31, DOI 10.1007/s11154-010-9131-7
   Carreira RS, 2010, AUTOPHAGY, V6, P462, DOI 10.4161/auto.6.4.11553
   Clark JE, 2003, CIRC RES, V93, pE2, DOI 10.1161/01.RES.0000084381.86567.08
   Grilli A, 2003, ANN CLIN LAB SCI, V33, P208
   Guo YR, 2004, AM J PHYSIOL-HEART C, V286, pH1649, DOI 10.1152/ajpheart.00971.2003
   Kuznetsov AV, 2008, NAT PROTOC, V3, P965, DOI 10.1038/nprot.2008.61
   Lancel S, 2009, J PHARMACOL EXP THER, V329, P641, DOI 10.1124/jpet.108.148049
   Lee SJ, 2011, AM J RESP CELL MOL, V45, P867, DOI 10.1165/rcmb.2010-0352OC
   Lee-Young RS, 2009, J BIOL CHEM, V284, P23925, DOI 10.1074/jbc.M109.021048
   Lehman JJ, 2000, J CLIN INVEST, V106, P847, DOI 10.1172/JCI10268
   Lo Iacono L, 2011, FREE RADICAL BIO MED, V50, P1556, DOI 10.1016/j.freeradbiomed.2011.02.033
   Loennechen JP, 1999, PHARMACOL TOXICOL, V85, P192, DOI 10.1111/j.1600-0773.1999.tb00091.x
   Marechal X, 2011, CLIN SCI, V121, P405, DOI 10.1042/CS20110069
   Motterlini R, 2010, NAT REV DRUG DISCOV, V9, P728, DOI 10.1038/nrd3228
   Nakai A, 2007, NAT MED, V13, P619, DOI 10.1038/nm1574
   Ndisang JF, 2009, AM J PHYSIOL-ENDOC M, V296, pE1029, DOI 10.1152/ajpendo.90241.2008
   Neviere R, 2010, CRIT CARE MED, V38, P2031, DOI 10.1097/CCM.0b013e3181eedafb
   Nicholls D., 2002, BIOENERGETICS, V3
   Ong SB, 2010, CIRCULATION, V121, P2012, DOI 10.1161/CIRCULATIONAHA.109.906610
   PACE N, 1950, SCIENCE, V111, P652, DOI 10.1126/science.111.2894.652
   REGAN TJ, 1977, J CLIN INVEST, V60, P885, DOI 10.1172/JCI108843
   Rhodes MA, 2009, AM J PHYSIOL-HEART C, V297, pH392, DOI 10.1152/ajpheart.00164.2009
   Somoza B, 2007, ENDOCRINOLOGY, V148, P924, DOI 10.1210/en.2006-0914
   Soni H, 2011, TOXICOL APPL PHARM, V253, P70, DOI 10.1016/j.taap.2011.03.013
   Suliman HB, 2007, J CLIN INVEST, V117, P3730, DOI 10.1172/JCI32967
   Suliman HB, 2007, J CELL SCI, V120, P299, DOI 10.1242/jcs.03318
   Urquhart P, 2007, J PHARMACOL EXP THER, V321, P656, DOI 10.1124/jpet.106.117218
   Wirawan E, 2012, CELL RES, V22, P43, DOI 10.1038/cr.2011.152
   Wu LY, 2005, PHARMACOL REV, V57, P585, DOI 10.1124/pr.57.4.3
   Yet SF, 2001, CIRC RES, V89, P168, DOI 10.1161/hh1401.093314
NR 32
TC 53
Z9 61
U1 0
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 1
PY 2012
VL 7
IS 8
AR e41836
DI 10.1371/journal.pone.0041836
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 984SU
UT WOS:000307212800036
PM 22870253
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU de Oliveira, PRB
   da Costa, CA
   de Bem, GF
   de Cavalho, LCRM
   de Souza, MAV
   Neto, MD
   Sousa, PJD
   de Moura, RS
   Resende, AC
AF Braz de Oliveira, Paola Raquel
   da Costa, Cristiane Aguiar
   de Bem, Graziele Freitas
   Reis Marins de Cavalho, Lenize Costa
   Vieira de Souza, Marcelo Augusto
   de Lemos Neto, Miguel
   da Cunha Sousa, Pergentino Jose
   de Moura, Roberto Soares
   Resende, Angela Castro
TI Effects of an Extract Obtained From Fruits of Euterpe oleracea
   Mart. in the Components of Metabolic Syndrome Induced in C57BL/6J Mice
   Fed a High-fat Diet
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
LA English
DT Article
DE Euterpe oleracea Mart.; Acai; metabolic syndrome; antioxidant; nitric
   oxide
ID INSULIN-RESISTANCE; ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS; OBESITY;
   EXPRESSION; ADIPOSE; ANTHOCYANINS; ANTIOXIDANTS; PATHOGENESIS;
   STIMULATION
AB Previously, we have demonstrated that the seed of Euterpe oleracea Mart. (acai) from the Amazon region exerts vasodilator and antihypertensive actions. The aim of our study was to assess the effects of oral chronic treatment with acai seed extract (ASE, 300 mg.kg(-1).d(-1)) on high-fat (HF) diet-induced metabolic syndrome (MS) in C57BL/6J mice. Four groups of C57BL/6 mice were fed with control diet (10% fat), ASE (10% fat), HF (60% fat), and HF + ASE (60% fat plus ASE) for 12 weeks. The vasodilator effects of acetylcholine (ACh) and nitroglycerine (NG) were studied in perfused mesenteric arterial bed. Body weight, plasma total cholesterol, triglyceride, glucose and insulin levels, oral glucose tolerance test, and oxidative damage were determined, and the insulin resistance measured by Homeostatic Model Assessment (HOMA) index. Vasodilator response to ACh but not to NG was reduced in HF mice, and ASE restored the response. Increased plasma malondialdehyde levels, body weight, plasma triglyceride, total cholesterol, glucose levels, and insulin resistance were observed in HF mice and reduced by ASE. Treatment with ASE also reduced glucose intolerance observed by oral glucose tolerance test in HF mice. In conclusion, ASE protected C57BL/6J mice fed HF diet from phenotypic and metabolic characteristics of MS, providing an alternative nutritional resource for prevention of MS.
C1 [Braz de Oliveira, Paola Raquel; da Costa, Cristiane Aguiar; de Bem, Graziele Freitas; Reis Marins de Cavalho, Lenize Costa; Vieira de Souza, Marcelo Augusto; de Lemos Neto, Miguel; de Moura, Roberto Soares; Resende, Angela Castro] Univ Estado Rio de Janeiro, Dept Pharmacol, Inst Biol, BR-20551030 Rio De Janeiro, Brazil.
   [da Cunha Sousa, Pergentino Jose] Fed Univ Para, Dept Pharm, Amapa, Para, Brazil.
C3 Universidade do Estado do Rio de Janeiro; Universidade Federal do Para
RP Resende, AC (corresponding author), Univ Estado Rio de Janeiro, Dept Farmacol & Psicobiol, IB, Ave 28 Setembro,87, BR-20551030 Rio De Janeiro, Brazil.
EM angelacr@uerj.br
RI Resende, Angela/M-8632-2017; Costa, Cristiane/AAF-8475-2021; Souza,
   Marcelo/V-7696-2019; de Bem, Graziele/AAB-6394-2019
OI Aguiar da Costa, Cristiane/0000-0003-1927-1794; de Bem,
   Graziele/0000-0002-9094-1597
FU National Council of Scientific and Technological Development (Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico); Rio de Janeiro
   State Research Agency (Fundacao de Amparo a Pesquisa do Estado do Rio de
   Janeiro)
FX Sources of Support: This work was conducted with grants from National
   Council of Scientific and Technological Development (Conselho Nacional
   de Desenvolvimento Cientifico e Tecnologico) and Rio de Janeiro State
   Research Agency (Fundacao de Amparo a Pesquisa do Estado do Rio de
   Janeiro).
CR Abdul-Ghani MA, 2006, DIABETES CARE, V29, P1130, DOI 10.2337/dc05-2179
   Arita Y, 1999, BIOCHEM BIOPH RES CO, V257, P79, DOI 10.1006/bbrc.1999.0255
   Balon TW, 1997, J APPL PHYSIOL, V82, P359, DOI 10.1152/jappl.1997.82.1.359
   Bastard JP, 2006, EUR CYTOKINE NETW, V17, P4
   Bobbio F. O., 2000, Ciencia e Tecnologia de Alimentos, V20, P388, DOI 10.1590/S0101-20612000000300018
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Cai H, 2000, CIRC RES, V87, P840, DOI 10.1161/01.RES.87.10.840
   Choi JS, 2007, BRIT J NUTR, V98, P264, DOI 10.1017/S000711450770497X
   Cong WN, 2008, LIFE SCI, V82, P983, DOI 10.1016/j.lfs.2008.01.022
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   de Moura RS, 2004, J CARDIOVASC PHARM, V44, P302, DOI 10.1097/01.fjc.0000133060.10597.3c
   Del Pozo-Insfran D, 2004, J AGR FOOD CHEM, V52, P1539, DOI 10.1021/jf035189n
   Devaskar SU, 2007, REV ENDOCR METAB DIS, V8, P105, DOI 10.1007/s11154-007-9050-4
   Dohadwala MM, 2009, J NUTR, V139, p1788S, DOI 10.3945/jn.109.107474
   DRAPER HH, 1993, FREE RADICAL BIO MED, V15, P353, DOI 10.1016/0891-5849(93)90035-S
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Evans JL, 2007, INDIAN J MED RES, V125, P355
   Fitzpatrick DF, 2000, J AGR FOOD CHEM, V48, P6384, DOI 10.1021/jf0009347
   Fortuño A, 2009, J HYPERTENS, V27, P1420, DOI 10.1097/HJH.0b013e32832b1e8f
   FRANKEL EN, 1993, LANCET, V341, P454, DOI 10.1016/0140-6736(93)90206-V
   GALLORI S, 2004, MART, V59, P739
   Gallou-Kabani C, 2007, OBESITY, V15, P1996, DOI 10.1038/oby.2007.238
   Godoy-Matos A, 2005, J CLIN ENDOCR METAB, V90, P1460, DOI 10.1210/jc.2004-0263
   Gogia Atul, 2006, Indian J Med Sci, V60, P72
   Lerman LO, 2005, J LAB CLIN MED, V146, P160, DOI 10.1016/j.lab.2005.05.005
   Lichtenthäler R, 2005, INT J FOOD SCI NUTR, V56, P53, DOI 10.1080/09637480500082082
   Lira VA, 2007, AM J PHYSIOL-ENDOC M, V293, pE1062, DOI 10.1152/ajpendo.00045.2007
   Maeda K, 1996, BIOCHEM BIOPH RES CO, V221, P286, DOI 10.1006/bbrc.1996.0587
   Matsuzawa-Nagata N, 2008, METABOLISM, V57, P1071, DOI 10.1016/j.metabol.2008.03.010
   MCGREGOR DD, 1965, J PHYSIOL-LONDON, V177, P21, DOI 10.1113/jphysiol.1965.sp007572
   Mertens-Talcott SU, 2008, J AGR FOOD CHEM, V56, P7796, DOI 10.1021/jf8007037
   Molnar J, 2005, CIRC RES, V96, P1178, DOI 10.1161/01.RES.0000168634.74330.ed
   Mundy AL, 2007, CARDIOVASC RES, V73, P368, DOI 10.1016/j.cardiores.2006.11.019
   REEVES PG, 1993, J NUTR, V123, P1939, DOI 10.1093/jn/123.11.1939
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Rocha APM, 2007, VASC PHARMACOL, V46, P97, DOI 10.1016/j.vph.2006.08.411
   Rocha A. P. M., 2008, Journal of Pharmacology and Toxicology, V3, P435
   Roy D, 1998, AM J PHYSIOL-ENDOC M, V274, pE692, DOI 10.1152/ajpendo.1998.274.4.E692
   SCHERER PE, 1995, J BIOL CHEM, V270, P26746, DOI 10.1074/jbc.270.45.26746
   Seifried HE, 2007, J NUTR BIOCHEM, V18, P567, DOI 10.1016/j.jnutbio.2006.10.007
   Singleton V., 1965, Methods Enzymol, V16, P144, DOI 10.5344/ajev.1965.16.3.144
   Stoclet JC, 2004, EUR J PHARMACOL, V500, P299, DOI 10.1016/j.ejphar.2004.07.034
   Tao RY, 2009, EUR J PHARMACOL, V616, P328, DOI 10.1016/j.ejphar.2009.06.011
   Tsuda T, 2008, J AGR FOOD CHEM, V56, P642, DOI 10.1021/jf073113b
   Williams TD, 2003, CLIN EXP PHARMACOL P, V30, P769, DOI 10.1046/j.1440-1681.2003.t01-1-03808.x
   Yoshikawa M, 2002, J NUTR, V132, P1819, DOI 10.1093/jn/132.7.1819
NR 46
TC 35
Z9 38
U1 0
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0160-2446
EI 1533-4023
J9 J CARDIOVASC PHARM
JI J. Cardiovasc. Pharmacol.
PD DEC
PY 2010
VL 56
IS 6
BP 619
EP 626
DI 10.1097/FJC.0b013e3181f78da4
PG 8
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 692FI
UT WOS:000285138000007
PM 20838232
DA 2025-06-11
ER

PT J
AU Scuteri, A
   Najjar, SS
   Orru', M
   Usala, G
   Piras, MG
   Ferrucci, L
   Cao, A
   Schlessinger, D
   Uda, M
   Lakatta, EG
AF Scuteri, Angelo
   Najjar, Samer S.
   Orru', Marco
   Usala, Gianluca
   Piras, Maria Grazia
   Ferrucci, Luigi
   Cao, Antonio
   Schlessinger, David
   Uda, Manuela
   Lakatta, Edward G.
TI The central arterial burden of the metabolic syndrome is similar in men
   and women: the SardiNIA Study
SO EUROPEAN HEART JOURNAL
LA English
DT Article
DE Metabolic syndrome; Ageing; Gender; Arterial stiffness; Carotid IMT
ID EARLY CAROTID ATHEROSCLEROSIS; CARDIOVASCULAR RISK; STIFFNESS; DISEASE;
   ADULTS; AGE
AB We evaluated whether specific clusters of metabolic syndrome (MetS) components differentially impact on arterial structure and function, and whether the impact is similar in men and in women.
   Components of the MetS and arterial properties were assessed in 6148 subjects, aged 14-102 in a cluster of four towns in Sardinia, Italy. MetS was defined in accordance with the ATP III criteria. Age groups were classified as: < 35, 35-49, 50-64, and >= 65 years. Systolic blood pressure (BP), diastolic BP, pulse pressure, common carotid artery (CCA) diameter, intima-media thickness, distensibility, strain, stiffness index, wall stress, and aortic pulse wave velocity were measured. Common carotid artery plaque was defined as focal encroachment of the arterial wall and CCA calcification as acoustic shadowing. In any age group, subjects with MetS presented thicker, stiffer or less distensible, and wider large arteries than controls. The arterial burden of MetS increased as the number of altered MetS components increased. However, not all MetS components were associated with the same changes in arterial properties. In fact, specific clusters of MetS components, i.e. any combination of altered glucose tolerance, elevated BP, and elevated triglycerides (with or without abdominal obesity), dramatically increased age-associated arterial changes. The impact of MetS on arterial function was similar in men and women.
   MetS accelerates age-associated arterial changes, even in older persons. However, not all the clusters of MetS components render the same burden on arterial structure and function.
C1 [Scuteri, Angelo; Najjar, Samer S.; Lakatta, Edward G.] NIA, Cardiovasc Sci Lab, NIH, Baltimore, MD 21224 USA.
   [Scuteri, Angelo; Orru', Marco; Usala, Gianluca; Piras, Maria Grazia; Cao, Antonio; Uda, Manuela] Cittadella Univ Monserrato, CNR, INN, I-09042 Cagliari, Italy.
   [Ferrucci, Luigi] NIA, Longitudinal Study Sect, NIH, Baltimore, MD 21224 USA.
   [Schlessinger, David] NIA, Genet Lab, NIH, Baltimore, MD 21224 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); Consiglio Nazionale delle Ricerche (CNR); University of
   Cagliari; National Institutes of Health (NIH) - USA; NIH National
   Institute on Aging (NIA); National Institutes of Health (NIH) - USA; NIH
   National Institute on Aging (NIA)
RP Scuteri, A (corresponding author), IRCCS, INRCA, UO Geriatria, Via Cassia 1167, I-00189 Rome, Italy.
EM angeloelefante@interfree.it
RI Ferrucci, Luigi/AED-9724-2022; Lakatta, Edward/AAL-1447-2020; Uda,
   Manuela/AAC-2645-2019; piras, maria grazia/P-2061-2018
OI piras, maria grazia/0000-0001-9004-0900; Ferrucci,
   Luigi/0000-0002-6273-1613; SCUTERI, ANGELO/0000-0003-4784-5441; Lakatta,
   Edward/0000-0002-4772-0035; UDA, MANUELA/0000-0002-4890-6456
FU NIA [NO1-AG-1-2109]
FX The SardiNIA team was supported by Contract NO1-AG-1-2109 from the NIA.
CR [Anonymous], 2002, Diabetes care, V25, pS1
   Bussy C, 2000, HYPERTENSION, V35, P1049, DOI 10.1161/01.HYP.35.5.1049
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Deedwania PC, 2004, CIRCULATION, V109, P2, DOI 10.1161/01.CIR.0000110642.73995.BF
   Ferreira I, 2007, J HYPERTENS, V25, P1009, DOI 10.1097/HJH.0b013e3280a94e76
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Iglseder B, 2005, STROKE, V36, P1212, DOI 10.1161/01.STR.0000166196.31227.91
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   Kass DA, 2001, CIRCULATION, V104, P1464, DOI 10.1161/hc3801.097806
   Kawamoto R, 2007, J ATHEROSCLER THROMB, V14, P36, DOI 10.5551/jat.14.36
   Lakatta EG, 2003, CIRCULATION, V107, P139, DOI 10.1161/01.CIR.0000048892.83521.58
   Mancia G, 2007, J HYPERTENS, V25, P1751, DOI 10.1097/HJH.0b013e3282f0580f
   Najjar SS, 2005, HYPERTENSION, V46, P454, DOI 10.1161/01.HYP.0000177474.06749.98
   Nilsson PM, 2008, J HYPERTENS, V26, P1049, DOI 10.1097/HJH.0b013e3282f82c3e
   Pilia G, 2006, PLOS GENET, V2, P1207, DOI 10.1371/journal.pgen.0020132
   Protogerou AD, 2007, ATHEROSCLEROSIS, V193, P151, DOI 10.1016/j.atherosclerosis.2006.05.046
   Scuteri A, 2004, J AM COLL CARDIOL, V43, P1388, DOI 10.1016/j.jacc.2003.10.061
   Scuteri A, 2005, DIABETES CARE, V28, P882, DOI 10.2337/diacare.28.4.882
   Skilton MR, 2007, ATHEROSCLEROSIS, V190, P416, DOI 10.1016/j.atherosclerosis.2006.02.019
   Stern MP, 2005, ATHEROSCLEROSIS SUPP, V6, P3, DOI 10.1016/j.atherosclerosissup.2005.02.002
   VAITKEVICIUS PV, 1993, CIRCULATION, V88, P1456, DOI 10.1161/01.CIR.88.4.1456
   Wang M, 2002, HYPERTENSION, V39, P865, DOI 10.1161/01.HYP.0000014506.13322.66
   Woodman RJ, 2008, CLIN SCI, V114, P119, DOI 10.1042/CS20070321
   You TJ, 2008, J GERONTOL A-BIOL, V63, P414, DOI 10.1093/gerona/63.4.414
NR 24
TC 86
Z9 92
U1 1
U2 10
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0195-668X
EI 1522-9645
J9 EUR HEART J
JI Eur. Heart J.
PD MAR
PY 2010
VL 31
IS 5
BP 602
EP 613
DI 10.1093/eurheartj/ehp491
PG 12
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 564UA
UT WOS:000275241900020
PM 19942601
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Wang, YH
   Yang, H
   Meng, P
   Han, YS
AF Wang, Yuhong
   Yang, Hui
   Meng, Pan
   Han, Yuanshan
TI Association between low serum 25-hydroxyvitamin D and depression in a
   large sample of Chinese patients with type 2 diabetes mellitus
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Diabetes; Depression; 25-hydroxyvitamin D
ID VITAMIN-D LEVELS; OLDER-ADULTS; METABOLIC SYNDROME; GLYCEMIC CONTROL;
   RISK-FACTOR; US ADULTS; SYMPTOMS; METAANALYSIS; HEALTH; PREVALENCE
AB Background: Because of the absence of data on the direct association between vitamin D and depression in patients with diabetes, we examined the association between vitamin D state (assessed by 25-hydroxyvitamin D [ 25(OH) D]) and the prevalence of depression in adult patients with type 2 diabetes mellitus(T2DM).
   Method: Cross-sectional data were obtained from 2786 patients with T2DM recruited from a Chinese diabetes registry. Patients' records were reviewed to obtain data pertaining to age, sex, Body Mass Index (BMI), marital status, level of education, smoking status, duration of diabetes mellitus, use of insulin, and presence of additional illnesses. A multiple logistic regression analysis adjusted for potential confounders was used to assess independent associations between serum levels of 25 (OH) D and depression (defined by the Patient Health Questionnaire-9).
   Results: Using the PHQ-9 cutoff value of >= 10, 5.71% (159/2786; 95% CI: 4.85-6.57%) were considered to have depression. The serum 25(OH) D levels were significantly lower in diabetic patients with depression than those patients without depression [10.2(IQR, 7.6-15.2) ng/ml vs. 14.6(IQR, 10.7-19.8)ng/ml, respectively; P < 0.0001]. Multivariate logistic regression analysis considering traditional risk factors and other biomarkers showed an inverse relationship between serum 25 (OH) D levels and depression when serum 25 (OH) D were used as a continuous variable (OR, 0.84; 95% CI, 0.77-0.90; P < 0.001). Compared with the first quartile of serum 25 (OH) D levels, the second quartile OR for depression was 0.83 (95% CI, 0.75-0.92, P=0.012). For the third and fourth quartiles, it was 0.40 (95% CI, 0.33-0.52, P < 0.001) and 0.15 (95% CI, 0.08-0.22; P < 0.001), respectively.
   Conclusions: We observed a significant negative association between serum levels of 25 (OH) D and depression in Chinese patients with T2DM.
C1 [Wang, Yuhong; Meng, Pan] Hunan Univ Chinese Med, State Key Lab Chinese Med Powder & Med Innovat Hu, Xiangzui Rd, Changsha 410208, Hunan, Peoples R China.
   [Yang, Hui; Han, Yuanshan] Hunan Univ Chinese Med, Hosp 1, Cent Lab, Changsha 410007, Hunan, Peoples R China.
C3 Hunan University of Chinese Medicine; Hunan University of Chinese
   Medicine
RP Wang, YH (corresponding author), Hunan Univ Chinese Med, State Key Lab Chinese Med Powder & Med Innovat Hu, Xiangzui Rd, Changsha 410208, Hunan, Peoples R China.
EM washjonyck@163.com
CR Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   Brouwer-Brolsma EM, 2016, EUR J NUTR, V55, P1525, DOI 10.1007/s00394-015-0970-6
   Chan R, 2011, J AFFECT DISORDERS, V130, P251, DOI 10.1016/j.jad.2010.10.029
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   de Groot M, 2007, DIABETES CARE, V30, P1602, DOI 10.2337/dc06-1599
   Egede LE, 2005, DIABETES CARE, V28, P1339, DOI 10.2337/diacare.28.6.1339
   Goldney RD, 2004, DIABETES CARE, V27, P1066, DOI 10.2337/diacare.27.5.1066
   Gorska-Ciebiada M, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0120433
   Gu L, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0065356
   Hoang MT, 2011, MAYO CLIN PROC, V86, P1050, DOI 10.4065/mcp.2011.0208
   Hoogendijk WJG, 2008, ARCH GEN PSYCHIAT, V65, P508, DOI 10.1001/archpsyc.65.5.508
   Husemoen LLN, 2012, DIABETES CARE, V35, P1695, DOI 10.2337/dc11-1309
   Jääskeläinen T, 2015, BRIT J NUTR, V113, P1418, DOI 10.1017/S0007114515000689
   Kivity S, 2011, CELL MOL IMMUNOL, V8, P243, DOI 10.1038/cmi.2010.73
   Knol MJ, 2006, DIABETOLOGIA, V49, P837, DOI 10.1007/s00125-006-0159-x
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Lacroix M, 2014, ACTA DIABETOL, V51, P609, DOI 10.1007/s00592-014-0564-4
   Li CY, 2008, DIABETES CARE, V31, P105, DOI 10.2337/dc07-1154
   Lu L, 2009, DIABETES CARE, V32, P1278, DOI 10.2337/dc09-0209
   Lustman PJ, 2000, DIABETES CARE, V23, P934, DOI 10.2337/diacare.23.7.934
   Manea L, 2012, CAN MED ASSOC J, V184, pE191, DOI 10.1503/cmaj.110829
   Mauss D, 2015, INT J MED SCI, V12, P362, DOI 10.7150/ijms.10540
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   MORISKY DE, 1986, MED CARE, V24, P67, DOI 10.1097/00005650-198601000-00007
   Nefs G, 2012, DIABETOLOGIA, V55, P608, DOI 10.1007/s00125-011-2411-2
   O'Hare C, 2016, J AFFECT DISORDERS, V191, P172, DOI 10.1016/j.jad.2015.11.029
   Okereke OI, 2016, J AFFECT DISORDERS, V198, P1, DOI 10.1016/j.jad.2016.03.022
   Sacco WP, 2007, HEALTH PSYCHOL, V26, P693, DOI 10.1037/0278-6133.26.6.693
   Sahota PKC, 2008, J CLIN PSYCHIAT, V69, P800, DOI 10.4088/JCP.v69n0513
   Salekzamani S, 2016, J ENDOCRINOL INVEST, V39, P1303, DOI 10.1007/s40618-016-0507-8
   Scragg R, 2004, DIABETES CARE, V27, P2813, DOI 10.2337/diacare.27.12.2813
   Song YQ, 2013, DIABETES CARE, V36, P1422, DOI 10.2337/dc12-0962
   Strine TW, 2008, GEN HOSP PSYCHIAT, V30, P127, DOI 10.1016/j.genhosppsych.2007.12.008
   Sweileh WM, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-163
   Wagner JA, 2009, J IMMIGR MINOR HEALT, V11, P66, DOI 10.1007/s10903-008-9147-1
   Weber B, 2000, EXP CLIN ENDOCR DIAB, V108, P187, DOI 10.1055/s-2000-7742
   Williams JA, 2015, J GERONTOL A-BIOL, V70, P757, DOI 10.1093/gerona/glu184
   Yang WY, 2010, NEW ENGL J MED, V362, P1090, DOI 10.1056/NEJMoa0908292
   Zhang YY, 2015, J DIABETES, V7, P800, DOI 10.1111/1753-0407.12238
   Zhang YY, 2013, J AFFECT DISORDERS, V151, P660, DOI 10.1016/j.jad.2013.07.014
NR 40
TC 13
Z9 16
U1 0
U2 45
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD DEC 15
PY 2017
VL 224
SI SI
BP 56
EP 60
DI 10.1016/j.jad.2016.10.040
PG 5
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA FK3EL
UT WOS:000413368300008
PM 27816323
DA 2025-06-11
ER

PT J
AU Rubio-Ruiz, ME
   El Hafidi, M
   Pérez-Torres, I
   Baños, G
   Guarner, V
AF Rubio-Ruiz, M. E.
   El Hafidi, M.
   Perez-Torres, I.
   Banos, G.
   Guarner, V.
TI Medicinal Agents and Metabolic Syndrome
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Article
DE Anti-inflammatory drugs; anti-oxidant drugs; lifestyle changes;
   medicinal plants; metabolic syndrome; pharmacological agents
ID HIGH-FAT DIET; FACTOR-KAPPA-B; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   SKELETAL-MUSCLE; BLOOD-PRESSURE; ANTIOXIDATIVE PROPERTIES; ENDOTHELIAL
   DYSFUNCTION; CARDIOVASCULAR-DISEASE; ESSENTIAL-HYPERTENSION
AB The definition of the Metabolic Syndrome (MS) has encountered difficulty in reaching a universal consensus although there exists an agreement of its main pathologies which are hypertension, obesity, dyslipidemia, insulin resistance, inflammation and renal damage. The prevalent opinion is that three of those alterations may define the syndrome. The incidence of the MS has increased globally, particularly in the last few years, to the point of being regarded as an epidemic. The treatment of the MS can be approached from different angles, since it may be a multifaceted health problem. A healthy lifestyle, which means the practice of regular exercise is suggested to MS patients. Increasing physical activity has anti-inflammatory effects since there is an inverse association of physical activity and inflammatory biomarker concentrations. An adequate diet is recommended, such as the Mediterranean, which contains fish, tomatoes, garlic, red peppers, olive oil and includes red wine, that is, antioxidants and non-saturated oils. There are also the traditional herbal preparations, used in the alternative medicine. Several therapeutic tools can be used; the most common are the pharmaceutical products to deal with obesity, hypertension, dyslipidemias, diabetes and inflammation. In addition several pharmacological therapies such as non steroidal anti-inflammatory drugs are recommended. Recently new mechanisms of action of statins, fibrates, metformin and thiazolidinediones have demonstrated their anti-inflammatory effect and potential use to treat MS.
C1 [Rubio-Ruiz, M. E.; Guarner, V.] Inst Nacl Cardiol Ignacio Chavez, Dept Fisiol, Tlalpan 14080, DF, Mexico.
   [El Hafidi, M.; Banos, G.] Inst Nacl Cardiol Ignacio Chavez, Dept Cardiovasc Biomed, Tlalpan 14080, DF, Mexico.
   [Perez-Torres, I.] Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Tlalpan 14080, DF, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico; National Institute of Cardiology - Mexico
RP Guarner, V (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Fisiol, Juan Badiano 1, Tlalpan 14080, DF, Mexico.
EM gualanv@yahoo.com
RI El-Hafidi, Mohammed/AAN-4083-2021; Pérez Torres, Israel/AAE-2579-2022;
   Guarner-Lans, Verónica/AFW-3723-2022
OI Rubio-Ruiz, Maria Esther/0000-0002-8844-2078; Perez-Torres,
   Israel/0000-0001-6510-2954; Guarner-Lans, Veronica/0000-0002-2655-7590
CR Adan RAH, 2013, TRENDS NEUROSCI, V36, P133, DOI 10.1016/j.tins.2012.12.001
   Ahmed HM, 2012, AM J CARDIOL, V109, P288, DOI 10.1016/j.amjcard.2011.08.042
   Al-Thanoon Zeina A, 2012, Oman Med J, V27, P27, DOI 10.5001/omj.2012.05
   Alvarez-Nemegyei J, 2006, REUMATOL CLIN, V2, P10, DOI 10.1016/S1699-258X(06)73014-5
   Amenta F, 2003, HYPERTENSION, V41, P1330, DOI 10.1161/01.HYP.0000070116.11304.23
   Anfossi G, 2009, NUTR METAB CARDIOVAS, V19, P440, DOI 10.1016/j.numecd.2009.01.006
   [Anonymous], AM J HYPERTENS
   [Anonymous], 2006, REV ENDOCRINOL NUTR
   Aoi W, 2011, J NUTR METAB, V2011, DOI 10.1155/2011/676208
   Athyros VG, 2007, EXPERT OPIN PHARMACO, V8, P2267, DOI 10.1517/14656566.8.14.2267
   Bashmakov YK, 2011, J DIABETES METAB, V2, DOI 10.4172/2155-6156.1000107e
   Berria R, 2007, CLIN PHARMACOL THER, V82, P275, DOI 10.1038/sj.clpt.6100146
   Boelsterli UA, 2002, BIOCHEM PHARMACOL, V63, P1, DOI 10.1016/S0006-2952(01)00817-6
   Borghi C, 2012, PATIENT PREFER ADHER, V6, P449, DOI 10.2147/PPA.S23232
   Borghi C, 2012, HIGH BLOOD PRESS CAR, V19, P19, DOI 10.2165/11632100-000000000-00000
   Bramlage P, 2008, MMW Fortschr Med, V149 Suppl 4, P172
   Bruun JM, 2006, AM J PHYSIOL-ENDOC M, V290, pE961, DOI 10.1152/ajpendo.00506.2005
   Bulckaen H, 2008, AM J PHYSIOL-HEART C, V294, pH1562, DOI 10.1152/ajpheart.00241.2007
   Capurso C, 2012, VASC PHARMACOL, V57, P91, DOI 10.1016/j.vph.2012.05.003
   Cardoso CG, 2010, CLINICS, V65, P317, DOI 10.1590/S1807-59322010000300013
   Chen JL, 2012, J ETHNOPHARMACOL, V139, P207, DOI 10.1016/j.jep.2011.11.002
   Chin BSP, 2003, EUR J HEART FAIL, V5, P171, DOI 10.1016/S1388-9842(02)00251-9
   Cornier MA, 2008, ENDOCR REV, V29, P777, DOI 10.1210/er.2008-0024
   Dandona P, 2004, TRENDS IMMUNOL, V25, P4, DOI 10.1016/j.it.2003.10.013
   Dangas GD, 2013, EUROINTERVENTION, V8, P1033, DOI 10.4244/EIJV8I9A159
   De Ciuceis C, 2011, HYPERTENSION, V58, P29, DOI 10.1161/HYPERTENSIONAHA.111.171082
   Deedwania P C, 2006, J Assoc Physicians India, V54, P797
   Deng S, 2004, ACTA PHARMACOL SIN, V25, P1633
   Dionne IJ, 2002, INT J OBESITY, V26, P633, DOI 10.1038/sj.ijo.0801971
   Edwards KM, 2007, J HYPERTENS, V25, P1533, DOI 10.1097/HJH.0b013e328165ca67
   Ellison DH, 2009, HYPERTENSION, V54, P196, DOI 10.1161/HYPERTENSIONAHA.109.129171
   Eriksson JW, 2007, FEBS LETT, V581, P3734, DOI 10.1016/j.febslet.2007.06.044
   Fajas L, 2003, J LIPID RES, V44, P1652, DOI 10.1194/jlr.M300248-JLR200
   Farpour-Lambert NJ, 2009, J AM COLL CARDIOL, V54, P2396, DOI 10.1016/j.jacc.2009.08.030
   Fernández-Real JM, 2003, ENDOCR REV, V24, P278, DOI 10.1210/er.2002-0010
   Forman LM, 2000, ANN INTERN MED, V132, P118, DOI 10.7326/0003-4819-132-2-200001180-00005
   Fritz T, 2006, DIABETES-METAB RES, V22, P492, DOI 10.1002/dmrr.656
   Fujita K, 2008, GUT, V57, P1583, DOI 10.1136/gut.2007.144550
   Glasser SP, 2008, PREV MED, V47, P161, DOI 10.1016/j.ypmed.2008.05.009
   Grundy SM, 2005, HANDB EXP PHARM, V170, P107
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Hainer V, 2012, DIABETES-METAB RES, V28, P8, DOI 10.1002/dmrr.2349
   Harris RC, 2008, CURR OPIN NEPHROL HY, V17, P64, DOI 10.1097/MNH.0b013e3282f1bb7d
   Hawkey CJ, 2001, BEST PRACT RES CL GA, V15, P801, DOI 10.1053/bega.2001.0236
   Hawley JA, 2008, ACTA PHYSIOL, V192, P127, DOI 10.1111/j.1748-1716.2007.01783.x
   Hayashi K, 2007, CIRC RES, V100, P342, DOI 10.1161/01.RES.0000256155.31133.49
   Hegarty BD, 2009, ACTA PHYSIOL, V196, P129, DOI 10.1111/j.1748-1716.2009.01968.x
   Hoene M, 2009, J PHYSIOL-LONDON, V587, P241, DOI 10.1113/jphysiol.2008.160275
   HOLLOSZY JO, 1984, J APPL PHYSIOL, V56, P831, DOI 10.1152/jappl.1984.56.4.831
   Huang XH, 2010, PHYTOMEDICINE, V17, P930, DOI 10.1016/j.phymed.2010.03.006
   Hunyadi A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023922
   Kadowaki T, 2006, J CLIN INVEST, V116, P1784, DOI 10.1172/JCI29126
   Keum YS, 2008, CARCINOGENESIS, V29, P594, DOI 10.1093/carcin/bgm208
   Kobayasi R, 2010, J HYPERTENS, V28, P2111, DOI 10.1097/HJH.0b013e32833ca68c
   Kohlstedt K, 2009, MOL PHARMACOL, V75, P685, DOI 10.1124/mol.108.051631
   Kotronen A, 2008, ARTERIOSCL THROM VAS, V28, P27, DOI 10.1161/ATVBAHA.107.147538
   Kunkel SD, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039332
   Layne AS, 2011, J CLIN ENDOCR METAB, V96, P1815, DOI 10.1210/jc.2010-2532
   Lehnen AM, 2011, HORM METAB RES, V43, P231, DOI 10.1055/s-0031-1271747
   Liu HB, 2012, TOXICOL IN VITRO, V26, P16, DOI 10.1016/j.tiv.2011.10.002
   Manabe S, 2005, J CARDIOVASC PHARM, V46, P735, DOI 10.1097/01.fjc.0000185783.00391.60
   Manrique C, 2010, HYPERTENSION, V55, P15, DOI 10.1161/HYPERTENSIONAHA.109.142620
   Martin C, 2011, PLANT CELL, V23, P1685, DOI 10.1105/tpc.111.083279
   Martínez-Flórez S, 2005, J NUTR, V135, P1359, DOI 10.1093/jn/135.6.1359
   Meier C, 2008, ARCH INTERN MED, V168, P820, DOI 10.1001/archinte.168.8.820
   Mengden T, 2009, VASC HEALTH RISK MAN, V5, P1043
   Menne J, 2006, FASEB J, V20, P994, DOI 10.1096/fj.05-4087fje
   Meyer-Sabellek W, 2006, J HYPERTENS, V24, P2349, DOI 10.1097/HJH.0b013e3280113648
   Mirrakhimov AE, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-89
   Miura SI, 2008, MOL ENDOCRINOL, V22, P139, DOI 10.1210/me.2007-0312
   Morley JE, 2004, J GERONTOL A-BIOL, V59, P139
   Na HK, 2008, ARCH BIOCHEM BIOPHYS, V476, P171, DOI 10.1016/j.abb.2008.04.003
   Nakamura T, 2010, EUR J CLIN INVEST, V40, P790, DOI 10.1111/j.1365-2362.2010.02319.x
   Olivares-Reyes JA, 2009, MOL CELL ENDOCRINOL, V302, P128, DOI 10.1016/j.mce.2008.12.011
   Oparil S, 2000, AM J HYPERTENS, V13, p18S, DOI 10.1016/S0895-7061(99)00250-2
   Park E, 2007, J ENDOCRINOL, V195, P323, DOI 10.1677/JOE-07-0005
   Pérez-Torres I, 2009, FREE RADICAL RES, V43, P761, DOI 10.1080/10715760903045296
   PEREZTORRES I, 2012, CARDIOVASC HEMATOL A, DOI DOI 10.1016/J.TEM.2012.06.008
   Petersen AMW, 2005, J APPL PHYSIOL, V98, P1154, DOI 10.1152/japplphysiol.00164.2004
   Philipp T, 2007, CLIN THER, V29, P563, DOI 10.1016/j.clinthera.2007.03.018
   Priebe HJ, 2009, MINERVA ANESTESIOL, V75, P319
   Pruijm MT, 2008, VASC HEALTH RISK MAN, V4, P1159
   Raghavan RP, 2006, BR J DIABETES VASC D, V6, P74
   Rao VS, 2011, J MED FOOD, V14, P1375, DOI 10.1089/jmf.2010.0267
   REAVEN GM, 1991, DIABETES CARE, V14, P195, DOI 10.2337/diacare.14.3.195
   Reboldi G, 2009, VASC HEALTH RISK MAN, V5, P411
   Reid JL, 2005, J RENIN-ANGIO-ALDO S, V6, P15, DOI 10.3317/jraas.2005.002
   Reilly MP, 2003, CIRCULATION, V108, P1546, DOI 10.1161/01.CIR.0000088846.10655.E0
   Reungjui S, 2007, J AM SOC NEPHROL, V18, P2724, DOI 10.1681/ASN.2007040416
   Richter EA, 2009, BIOCHEM J, V418, P261, DOI 10.1042/BJ20082055
   Rojas R, 2010, SALUD PUBLICA MEXICO, V52, pS11, DOI 10.1590/S0036-36342010000700004
   Rompe F, 2010, HYPERTENSION, V55, P924, DOI 10.1161/HYPERTENSIONAHA.109.147843
   Samaha FF, 2006, ARTERIOSCL THROM VAS, V26, P624, DOI 10.1161/01.ATV.0000200136.56716.30
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Singh S, 2007, JAMA-J AM MED ASSOC, V298, P1189, DOI 10.1001/jama.298.10.1189
   Snider ME, 2008, VASC HEALTH RISK MAN, V4, P1249
   Starkie R, 2003, FASEB J, V17, P884, DOI 10.1096/fj.02-0670fje
   Sugimoto K, 2006, HYPERTENSION, V47, P1003, DOI 10.1161/01.HYP.0000215181.60228.f7
   Surh YJ, 2008, GENES NUTR, V2, P313, DOI 10.1007/s12263-007-0063-0
   Tang DL, 2009, AM J RESP CELL MOL, V41, P651, DOI 10.1165/rcmb.2008-0119OC
   Tchernof A, 2013, PHYSIOL REV, V93, P359, DOI 10.1152/physrev.00033.2011
   Tsarouhas K, 2011, IN VIVO, V25, P1031
   Ungvari Z, 2010, AM J PHYSIOL-HEART C, V299, pH18, DOI 10.1152/ajpheart.00260.2010
   Van Gaal LF, 2006, NATURE, V444, P875, DOI 10.1038/nature05487
   VANE JR, 1971, NATURE-NEW BIOL, V231, P232, DOI 10.1038/newbio231232a0
   Vos MB, 2013, HEPATOLOGY, V57, P2525, DOI 10.1002/hep.26299
   Wallace MA, 2011, J PHYSIOL-LONDON, V589, P2027, DOI 10.1113/jphysiol.2011.205468
   White WB, 2007, HYPERTENSION, V49, P408, DOI 10.1161/01.HYP.0000258106.74139.25
   Wilson SL, 2006, J HYPERTENS, V24, P1457, DOI 10.1097/01.hjh.0000239278.82196.a5
   Wu R, 2002, CIRCULATION, V105, P387, DOI 10.1161/hc0302.102609
   Zambon A, 2006, ARTERIOSCL THROM VAS, V26, P977, DOI 10.1161/01.ATV.0000204327.96431.9a
   Zhang JQ, 2009, BIOORG MED CHEM LETT, V19, P3324, DOI 10.1016/j.bmcl.2009.04.050
   Zhang L, 2006, BLOOD COAGUL FIBRIN, V17, P259, DOI 10.1097/01.mbc.0000224844.33216.91
NR 113
TC 21
Z9 21
U1 0
U2 37
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PD JUL
PY 2013
VL 20
IS 21
BP 2626
EP 2640
DI 10.2174/0929867311320210002
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 160ZB
UT WOS:000320158000002
PM 23590715
DA 2025-06-11
ER

PT J
AU Hubar, AO
   Bilai, AI
   Bilai, M
AF Hubar, A. O.
   Bilai, A. I.
   Bilai, M.
TI Modern aspects of comorbidity of urological disease and metabolic
   syndrome
SO ZAPOROZHYE MEDICAL JOURNAL
LA English
DT Review
DE Key urolithiasis; metabolic syndrome; obesity; mellitus diabetes;
   hyperuricemia; oxidative stress
ID EAU GUIDELINES; OBESITY; MANAGEMENT; DIAGNOSIS; RISK
AB Urinary stone disease (USD) is one of the most common urological diseases occurring mainly in people of working age. USD is associated with metabolic disorders, the causes of which include endogenous and exogenous factors. Metabolic syndrome (MS) is a "non-infectious epidemic" that manifests itself in diabetes, hypertension, atherosclerosis, and obesity. The bidirectionality of metabolic processes is an important factor of USD and MS. Aim. The paper aims at reviewing modern literary sources regarding the determination of pathogenetic links between the comorbidity of USD and MS. Results. Nephrolithiasis spreads and recurs simultaneously with obesity. A decrease in urine pH, which is the basis for the formation of urate stones, is associated with the presence of obesity, insulin resistance, and MS. Under such conditions, urine alkalinization is the main treatment for urolithiasis. The risk of stone formation increases when the body mass index is more than 30 kg/m2. Among patients with insulin resistance, nephrolithiasis is more severe, and kidney stones occur more often. The relationship between the hypertensive component of MS and USD has been established. Disorders of lipid metabolism have a negative prognosis, causing physicochemical aberrations in urine and the development of nephrolithiasis. Hyperuricemia is related to both the ability of insulin to reduce uric acid clearance in the proximal renal tubules and insulin resistance. The link between USD and chronic inflammation is based on an increase in the endogenous synthesis of oxalates from endogenous glycogenic amino acids, which leads to the development of hyperoxaluria in patients with MS. Clinical studies show the formation of kidney stones in conditions of oxidative stress, an association between stone formation and the development of MS, coronary heart disease, arterial hypertension, which is the result of common pathogenetic characteristics. Conclusions. The comorbidity of USD and MS is a systemic disorder. Kidney stone formation is associated with a decrease in urine pH against the background of MS. Hyperuricemia is comorbid with insulin resistance, dyslipoproteinemia, arterial hypertension, and abdominal obesity. Systemic chronic inflammation, comorbid with obesity and USD, based on an increase in the endogenous synthesis of oxalates from endogenous glycogenic amino acids. Oxidative stress has a common pathogenetic link between stone formation and insulin resistance, atherosclerosis, hypertension, and obesity.
C1 [Hubar, A. O.] Zaporizhzhia State Med Univ, Dept Urol, Zaporizhia, Ukraine.
   [Bilai, A. I.] Zaporizhzhia State Med Univ, Dept Fac Surg, Zaporizhia, Ukraine.
   [Bilai, M.] Zaporizhzhia State Med Univ, Dept Clin Pharm Pharmacotherapy Pharmacognosy & Ph, Zaporizhia, Ukraine.
C3 Zaporizhzhia State Medical University; Zaporizhzhia State Medical
   University; Zaporizhzhia State Medical University
RP Bilai, M (corresponding author), Zaporizhzhia State Med Univ, Dept Clin Pharm Pharmacotherapy Pharmacognosy & Ph, Zaporizhia, Ukraine.
EM belay250455@gmail.com
RI Bilai, Andrii/AAA-2225-2019
OI Bilai, Andrii/0000-0001-7510-6684
CR Bachurin H. V., 2020, ZDOROVE MUZHCHINY, P71
   Batagello CA, 2018, J ENDOUROL, V32, P995, DOI 10.1089/end.2018.0294
   Besiroglu H, 2015, RENAL FAILURE, V37, P1, DOI 10.3109/0886022X.2014.976133
   Bigagli E, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/5953685
   Carbone A, 2018, MINERVA UROL NEFROL, V70, P393, DOI 10.23736/S0393-2249.18.03113-2
   Chernenko D. V., 2015, ZDOROVE MUZHCHINY, P129
   Cho ST, 2013, INT J UROL, V20, P208, DOI 10.1111/j.1442-2042.2012.03131.x
   Daudon M, 2006, UROL RES, V34, P193, DOI 10.1007/s00240-006-0042-8
   Dichi I., 2014, Role of oxidative stress in chronic diseases, DOI DOI 10.1201/B16653
   Ingimarsson JP, 2016, SURG CLIN N AM, V96, P517, DOI 10.1016/j.suc.2016.02.008
   Kim MJ, 2016, THER UMSCH, V73, P159, DOI 10.1024/0040-5930/a000773
   Kostecka M, 2014, PAK J MED SCI, V30, P1299, DOI 10.12669/pjms.306.5792
   Lee SJ, 2020, CLIN HYPERTENS, V26, DOI 10.1186/s40885-020-00146-y
   Liu XJ, 2018, UROLITHIASIS, V46, P211, DOI 10.1007/s00240-017-0974-1
   Loperena R, 2017, MED CLIN N AM, V101, P169, DOI 10.1016/j.mcna.2016.08.004
   Messiah SE, 2015, WORLD J DIABETES, V6, P200, DOI 10.4239/wjd.v6.i1.200
   Moran Conor P, 2016, Practitioner, V260, P17
   Morelli NR, 2018, ARCH ENDOCRIN METAB, V62, P309, DOI 10.20945/2359-3997000000036
   Mykhailovska NS, 2020, PATHOLOGIA, P156, DOI 10.14739/2310-1237.2020.2.212754
   Penniston KL, 2018, CURR UROL REP, V19, DOI 10.1007/s11934-018-0791-2
   Sakhaee K, 2012, J CLIN ENDOCR METAB, V97, P1847, DOI 10.1210/jc.2011-3492
   Sanchez-Lozada LG, 2020, AM J HYPERTENS, V33, P583, DOI 10.1093/ajh/hpaa044
   Solomchak D. B., 2019, PROBLEMY ENDOKRYNNOI, P52, DOI [10.21856/j-PEP.2019.2.08, DOI 10.21856/J-PEP.2019.2.08]
   Stus V. P., 2018, UROLOGIYA, V22, P58, DOI [10.26641/2307- 5279.22.3.2018.143275, DOI 10.26641/2307-5279.22.3.2018.143275]
   Türk C, 2016, EUR UROL, V69, P468, DOI 10.1016/j.eururo.2015.07.040
   Türk C, 2016, EUR UROL, V69, P475, DOI 10.1016/j.eururo.2015.07.041
   Venturini D, 2015, NUTR RES, V35, P759, DOI 10.1016/j.nutres.2015.06.013
   Vozianov SO, 2021, ZAPOROZHYE MED J, V23, P575, DOI 10.14739/2310-1210.2021.4.226895
   Vozianov SO, 2013, Urolohiia, V17, P89
   Zaitsev V. I., 2019, ZDOROVE MUZHCHINY, P79
NR 30
TC 0
Z9 0
U1 0
U2 3
PU ZAPORIZHZHYA STATE MEDICAL UNIV
PI ZAPORIZHZHYA
PA PR-KT MAYAKOVSKOGO, 26, ZAPORIZHZHYA, 69035, UKRAINE
SN 2306-4145
EI 2310-1210
J9 ZAPOROZHYE MED J
JI ZAPOROZHYE MED. J.
PD NOV-DEC
PY 2022
VL 24
IS 6
BP 742
EP 747
DI 10.14739/2310-1210.2022.6.266232
PG 6
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA 7R7LT
UT WOS:000910251900016
OA gold
DA 2025-06-11
ER

PT J
AU Lathigara, D
   Kaushal, D
   Wilson, RB
AF Lathigara, Dhruvi
   Kaushal, Devesh
   Wilson, Robert Beaumont
TI Molecular Mechanisms of Western Diet-Induced Obesity and Obesity-Related
   Carcinogenesis-A Narrative Review
SO METABOLITES
LA English
DT Review
DE bariatric surgery; breast cancer; colorectal carcinoma; crown-like
   structure (CLS); cytokine; exosome; GLP-1; HIF-1 alpha; hypoxia; leptin;
   macrophage polarization; metabolic syndrome; NASH; obesity; senescence
ID BODY-MASS INDEX; ADIPOSE-TISSUE; BREAST-CANCER; BARIATRIC SURGERY;
   HEPATOCELLULAR-CARCINOMA; METABOLIC SYNDROME; DNA METHYLATION;
   WEIGHT-LOSS; RISK; ASSOCIATION
AB The present study aims to provide a narrative review of the molecular mechanisms of Western diet-induced obesity and obesity-related carcinogenesis. A literature search of the Cochrane Library, Embase and Pubmed databases, Google Scholar and the grey literature was conducted. Most of the molecular mechanisms that induce obesity are also involved in the twelve Hallmarks of Cancer, with the fundamental process being the consumption of a highly processed, energy-dense diet and the deposition of fat in white adipose tissue and the liver. The generation of crown-like structures, with macrophages surrounding senescent or necrotic adipocytes or hepatocytes, leads to a perpetual state of chronic inflammation, oxidative stress, hyperinsulinaemia, aromatase activity, activation of oncogenic pathways and loss of normal homeostasis. Metabolic reprogramming, epithelial mesenchymal transition, HIF-1a signalling, angiogenesis and loss of normal host immune-surveillance are particularly important. Obesity-associated carcinogenesis is closely related to metabolic syndrome, hypoxia, visceral adipose tissue dysfunction, oestrogen synthesis and detrimental cytokine, adipokine and exosomal miRNA release. This is particularly important in the pathogenesis of oestrogen-sensitive cancers, including breast, endometrial, ovarian and thyroid cancer, but also 'non-hormonal' obesity-associated cancers such as cardio-oesophageal, colorectal, renal, pancreatic, gallbladder and hepatocellular adenocarcinoma. Effective weight loss interventions may improve the future incidence of overall and obesity-associated cancer.
C1 [Lathigara, Dhruvi; Kaushal, Devesh] UWS, Campbelltown Hosp, Dept Gen Surg, Campbelltown, NSW 2560, Australia.
   [Wilson, Robert Beaumont] UNSW, Liverpool Hosp, Dept Upper Gastrointestinal Surg, Liverpool, NSW 2170, Australia.
C3 NSW Health; Campbelltown Hospital; University of New South Wales Sydney;
   Liverpool Hospital
RP Wilson, RB (corresponding author), UNSW, Liverpool Hosp, Dept Upper Gastrointestinal Surg, Liverpool, NSW 2170, Australia.
EM robert.wilson@unsw.edu.au
OI Wilson, Robert/0000-0002-7408-4695
CR Aird R, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.989523
   Aleman JO, 2017, J ENDOCR SOC, V1, P625, DOI 10.1210/js.2017-00020
   Alexander M, 2019, BMC MED, V17, DOI 10.1186/s12916-019-1321-x
   Aminian A, 2022, JAMA-J AM MED ASSOC, V327, P2423, DOI 10.1001/jama.2022.9009
   [Anonymous], AD OB FACTS
   [Anonymous], 2017, Contin. Updat. Proj. Expert Rep, P120, DOI [10.1007/s12082-007-0105-4, DOI 10.1007/S12082-007-0105-4]
   [Anonymous], 2022, Obesity and cancer
   Athanasiadis DI, 2021, SURG ENDOSC, V35, P4069, DOI 10.1007/s00464-021-08329-w
   Atoum MF, 2020, BREAST CANCER-BASIC, V14, DOI 10.1177/1178223419898458
   Aune Dagfinn, 2011, BMJ, V343, pd6617, DOI 10.1136/bmj.d6617
   Australian Institute of Health and Welfare Cancer Data in Australia, CATNOCAN122
   Ayele TM, 2022, J INFLAMM RES, V15, P1349, DOI 10.2147/JIR.S353489
   Balkwill F, 2001, LANCET, V357, P539, DOI 10.1016/S0140-6736(00)04046-0
   Bao Y, 2013, JNCI-J NATL CANCER I, V105, P95, DOI 10.1093/jnci/djs474
   Berger NA, 2017, CANCER PREV RES, V10, P223, DOI 10.1158/1940-6207.CAPR-17-0062
   Bernstein H, 2005, MUTAT RES-REV MUTAT, V589, P47, DOI 10.1016/j.mrrev.2004.08.001
   Bhaskaran K, 2014, LANCET, V384, P755, DOI 10.1016/S0140-6736(14)60892-8
   Birts CN, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-11696-6
   Biswas V., 2022, Dietetics, V1, P182, DOI [10.3390/dietetics1030017, DOI 10.3390/DIETETICS1030017]
   Bonsignore MR, 2022, HANDB EXP PHARMACOL, V274, P181, DOI 10.1007/164_2021_558
   Bonsignore MR, 2012, EUR RESPIR J, V39, P1136, DOI 10.1183/09031936.00151110
   Bordonaro M, 2023, J CANCER, V14, P446, DOI 10.7150/jca.82393
   Bose S, 2019, TRENDS CELL BIOL, V29, P695, DOI 10.1016/j.tcb.2019.05.005
   Bouvard V, 2015, LANCET ONCOL, V16, P1599, DOI 10.1016/S1470-2045(15)00444-1
   Burkitt D., 1981, Western Diseases: Their Emergence and Prevention
   BURKITT DP, 1973, BMJ-BRIT MED J, V1, P274, DOI 10.1136/bmj.1.5848.274
   BURKITT DP, 1969, LANCET, V2, P1229, DOI 10.1016/S0140-6736(69)90757-0
   BURKITT DP, 1972, LANCET, V1, P1408
   Cancello R, 2005, DIABETES, V54, P2277, DOI 10.2337/diabetes.54.8.2277
   Caslin HL, 2023, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.984859
   Castagneto-Gissey L, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00213
   Chang KR, 2023, ECLINICALMEDICINE, V56, DOI 10.1016/j.eclinm.2023.101840
   Chen K, 2022, FRONT ONCOL, V12, DOI 10.3389/fonc.2022.820968
   Cinti S, 2005, J LIPID RES, V46, P2347, DOI 10.1194/jlr.M500294-JLR200
   Clapp B, 2023, BRIT J SURG, V110, P24, DOI 10.1093/bjs/znac343
   Cleary MP, 2009, ENDOCRINOLOGY, V150, P2537, DOI 10.1210/en.2009-0070
   Collado M, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24087317
   Costa DA, 2021, FRONT MICROBIOL, V12, DOI 10.3389/fmicb.2021.584332
   Crafts TD, 2022, OBESITY, V30, P587, DOI 10.1002/oby.23369
   Cramer T, 2023, SEMIN IMMUNOL, V66, DOI 10.1016/j.smim.2023.101736
   Crespi E, 2016, CURR OPIN PHARMACOL, V31, P114, DOI 10.1016/j.coph.2016.11.004
   Cummings JH, 2018, NUTR RES REV, V31, P1, DOI 10.1017/S0954422417000117
   da Silva LSL, 2023, NUTR HOSP, V40, P534, DOI 10.20960/nh.04270
   Doerstling SS, 2017, FRONT ONCOL, V7, DOI 10.3389/fonc.2017.00216
   Dong LX, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-41616-0
   Dumas JF, 2021, CANCER METAST REV, V40, P31, DOI 10.1007/s10555-020-09934-2
   Dvorak HF, 2015, CANCER IMMUNOL RES, V3, P1, DOI 10.1158/2326-6066.CIR-14-0209
   Ehrlich M, 2019, EPIGENETICS-US, V14, P1141, DOI 10.1080/15592294.2019.1638701
   ElGendy K, 2020, SURG OBES RELAT DIS, V16, P128, DOI 10.1016/j.soard.2019.09.075
   Engelking L.R., 2015, TXB VET PHYSIOLOGICA, P345, DOI [10.1016/B978-0-12-391909-0.50123-7, DOI 10.1016/B978-0-12-391909-0.50123-7]
   Faenza M, 2022, UPDATES SURG, V74, P431, DOI 10.1007/s13304-021-01162-9
   Fang Z, 2022, JNCI-J NATL CANCER I, V114, P361, DOI 10.1093/jnci/djab102
   Feigelson HS, 2021, JNCI-J NATL CANCER I, V113, P1156, DOI 10.1093/jnci/djab053
   Feldman DE, 2012, P NATL ACAD SCI USA, V109, P829, DOI 10.1073/pnas.1114438109
   Feletto E, 2022, LANCET REG HEALTH-W, V29, DOI 10.1016/j.lanwpc.2022.100575
   Feng SQ, 2019, PHARMACOL RES, V150, DOI 10.1016/j.phrs.2019.104500
   Ferreri C, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23116030
   Frederick A.L., 2021, INT J EPIGENETICS, V1, P4, DOI [10.3892/ije.2021.4, DOI 10.3892/IJE.2021.4]
   Friedenreich CM, 2021, MOL ONCOL, V15, P790, DOI 10.1002/1878-0261.12772
   Fu J, 2023, FRONT ONCOL, V13, DOI 10.3389/fonc.2023.1117846
   García-Estévez L, 2021, FRONT ONCOL, V11, DOI 10.3389/fonc.2021.705911
   Gasek NS, 2021, NATURE AGING, V1, P870, DOI 10.1038/s43587-021-00121-8
   Geng HW, 2021, FRONT MOL BIOSCI, V8, DOI 10.3389/fmolb.2021.634874
   Gianfredi V, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071579
   Gianfredi V, 2018, INT J FOOD SCI NUTR, V69, P904, DOI 10.1080/09637486.2018.1446917
   Gjermeni E, 2021, BIOMOLECULES, V11, DOI 10.3390/biom11101426
   Goedert JJ, 2015, JNCI-J NATL CANCER I, V107, DOI 10.1093/jnci/djv147
   Gomes S, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24065069
   Goncalves MD, 2019, SCIENCE, V363, P1345, DOI 10.1126/science.aat8515
   Greene MW, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0268436
   Grohmann M, 2018, CELL, V175, P1289, DOI 10.1016/j.cell.2018.09.053
   Gu YM, 2018, J CANCER, V9, P2532, DOI 10.7150/jca.23535
   Gualano B, 2021, EXERC SPORT SCI REV, V49, P197, DOI 10.1249/JES.0000000000000253
   Guerrini V, 2019, TRENDS IMMUNOL, V40, P1163, DOI 10.1016/j.it.2019.10.002
   Guz M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13072428
   Hanahan D, 2022, CANCER DISCOV, V12, P31, DOI 10.1158/2159-8290.CD-21-1059
   Hernández MAG, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081943
   Heyn GS, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.563816
   Honecker J, 2022, EBIOMEDICINE, V79, DOI 10.1016/j.ebiom.2022.104020
   Hu JX, 2021, WORLD J GASTROENTERO, V27, P4298, DOI 10.3748/wjg.v27.i27.4298
   Huber Y, 2019, ALIMENT PHARM THER, V50, P930, DOI 10.1111/apt.15427
   Hullings AG, 2020, AM J CLIN NUTR, V112, P603, DOI 10.1093/ajcn/nqaa161
   Itoh M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0082163
   Iyengar NM, 2017, CANCER PREV RES, V10, P235, DOI 10.1158/1940-6207.CAPR-16-0314
   Jafari N, 2022, NAT REV ENDOCRINOL, V18, P327, DOI 10.1038/s41574-022-00666-7
   Jiang YH, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms6566
   Jiang YH, 2014, MOL CELL, V53, P75, DOI 10.1016/j.molcel.2013.11.001
   Jiménez-Cortegana C, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9070762
   Karra P, 2022, OBESITY, V30, P1323, DOI 10.1002/oby.23444
   Kawai T, 2021, AM J PHYSIOL-CELL PH, V320, pC375, DOI 10.1152/ajpcell.00379.2020
   Kawano Jordan, 2009, J Cardiometab Syndr, V4, P44, DOI 10.1111/j.1559-4572.2008.00030.x
   Kessoku T, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.770986
   King SE, 2020, TRENDS ENDOCRIN MET, V31, P478, DOI 10.1016/j.tem.2020.02.009
   Kozarzewski L, 2022, REV ENDOCR METAB DIS, V23, P773, DOI 10.1007/s11154-021-09701-w
   Kshitiz Afzal J, 2022, CELL SYST, V13, P1048, DOI DOI 10.1016/j.cels.2022.11.003
   Kundel V, 2021, NAT SCI SLEEP, V13, P1943, DOI 10.2147/NSS.S327341
   Kwan HY, 2021, CELL MOL LIFE SCI, V78, P7275, DOI 10.1007/s00018-021-03973-w
   Lagarde D, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.689747
   Lauby-Secretan B, 2016, NEW ENGL J MED, V375, P794, DOI 10.1056/NEJMsr1606602
   Lavie L, 2019, INTERMITTENT HYPOXIA
   Tran LT, 2022, EXP MOL MED, V54, P358, DOI 10.1038/s12276-022-00741-z
   Lee SH, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10092371
   Lefere S, 2019, JHEP REP, V1, P30, DOI 10.1016/j.jhepr.2019.02.004
   LeVee A, 2023, CANCERS, V15, DOI 10.3390/cancers15092526
   Li J, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.594408
   Li Q, 2022, FRONT CELL DEV BIOL, V10, DOI 10.3389/fcell.2022.1003219
   Li Q, 2021, NAT MED, V27, P1941, DOI 10.1038/s41591-021-01501-8
   Li X, 2021, CANCER CELL INT, V21, DOI 10.1186/s12935-021-02121-5
   Li XJ, 2018, MOL CELL, V72, P650, DOI 10.1016/j.molcel.2018.09.007
   Li XJ, 2016, MOL CELL, V61, P705, DOI 10.1016/j.molcel.2016.02.009
   Li Z, 2023, JCI INSIGHT, V8, DOI 10.1172/jci.insight.166655
   Liao LP, 2022, ACTA PHARM SIN B, V12, P4180, DOI 10.1016/j.apsb.2022.05.012
   Lin XH, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.706978
   Liu XZ, 2021, CELL STRESS, V5, P55, DOI 10.15698/cst2021.05.248
   Liu YJ, 2022, FRONT ONCOL, V12, DOI 10.3389/fonc.2022.813745
   Liu YN, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.669429
   Loomis AK, 2016, J CLIN ENDOCR METAB, V101, P945, DOI 10.1210/jc.2015-3444
   Loos RJF, 2022, NAT REV GENET, V23, P120, DOI 10.1038/s41576-021-00414-z
   Luo JH, 2022, PHARMACOL RES, V184, DOI 10.1016/j.phrs.2022.106461
   Luo WB, 2011, CELL, V145, P732, DOI 10.1016/j.cell.2011.03.054
   Ma HH, 2020, CELL REP, V30, P4235, DOI 10.1016/j.celrep.2020.03.005
   MacLean PS, 2015, OBES REV, V16, P45, DOI 10.1111/obr.12255
   Maharjan BR, 2021, PHYSIOL REP, V9, DOI 10.14814/phy2.14929
   Mahmod AI, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.924192
   Maliniak ML, 2021, CANCERS, V13, DOI 10.3390/cancers13092222
   Martins FF, 2023, LIFE SCI, V313, DOI 10.1016/j.lfs.2022.121268
   Masoud GN, 2015, ACTA PHARM SIN B, V5, P378, DOI 10.1016/j.apsb.2015.05.007
   Mei RY, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.873865
   Milner JJ, 2022, J PERS MED, V12, DOI 10.3390/jpm12050660
   Mingrone G, 2021, LANCET, V397, P293, DOI 10.1016/S0140-6736(20)32649-0
   Miyoshi Y, 2003, CLIN CANCER RES, V9, P5699
   Mohajer N, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.787580
   Moldogazieva NT, 2020, CANCERS, V12, DOI 10.3390/cancers12040862
   Molina-Montes E, 2020, NUTRIENTS, V12, DOI 10.3390/nu12072010
   Morkel M, 2015, ONCOTARGET, V6, P20785, DOI 10.18632/oncotarget.4750
   Munhoz AC, 2023, AGING CELL, V22, DOI 10.1111/acel.13827
   Murphy N, 2023, JNCI-J NATL CANCER I, V115, P165, DOI 10.1093/jnci/djac215
   Murphy N, 2016, PLOS MED, V13, DOI 10.1371/journal.pmed.1001988
   Murray CJL, 2020, LANCET, V396, P1223, DOI [10.1016/S0140-6736(20)30752-2, 10.1016/S0140-6736(20)30925-9]
   Nguyen TNQ, 2022, J HEMATOL ONCOL, V15, DOI 10.1186/s13045-022-01303-6
   Nocquet L, 2020, CANCERS, V12, DOI 10.3390/cancers12103017
   Nucci D, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18084168
   O'Keefe SJ, 2019, LANCET GASTROENTEROL, V4, P984, DOI 10.1016/S2468-1253(19)30257-2
   Obradovic M, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.585887
   Ohtani N, 2022, INFLAMM REGEN, V42, DOI 10.1186/s41232-022-00197-8
   Olea-Flores M, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10121676
   Olona A, 2021, BMC BIOL, V19, DOI 10.1186/s12915-021-01181-3
   Pais R, 2017, ALIMENT PHARM THER, V46, P856, DOI 10.1111/apt.14261
   Palomäki VA, 2023, OBESITY, V31, P184, DOI 10.1002/oby.23602
   Pant Deepak, 2022, Subcell Biochem, V100, P361, DOI 10.1007/978-3-031-07634-3_11
   Pardo F, 2018, MOL ASPECTS MED, V60, P81, DOI 10.1016/j.mam.2017.11.010
   Pasquarelli-do-Nascimento G, 2022, IMMUNOTHER ADV, V2, DOI 10.1093/immadv/ltac015
   Patterson R, 2018, EUR J EPIDEMIOL, V33, P811, DOI 10.1007/s10654-018-0380-1
   Peled S, 2021, FOOD HYDROCOLLOID, V120, DOI 10.1016/j.foodhyd.2021.106911
   Pellegata NS, 2022, CANCER METAST REV, V41, P517, DOI 10.1007/s10555-022-10058-y
   Pérez-Hernández AI, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00065
   Pham DV, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22031444
   Pini M, 2021, AGING CELL, V20, DOI 10.1111/acel.13421
   Poblete JMS, 2020, AM J PHYSIOL-ENDOC M, V318, pE689, DOI 10.1152/ajpendo.00174.2019
   Pontzer H, 2016, CURR BIOL, V26, P410, DOI 10.1016/j.cub.2015.12.046
   Purohit A, 2002, BREAST CANCER RES, V4, P65, DOI 10.1186/bcr425
   Quan MC, 2020, PHARM RES-DORDR, V37, DOI 10.1007/s11095-020-02941-6
   Rabhi N, 2022, LIFE SCI ALLIANCE, V5, DOI 10.26508/lsa.202101286
   Rakib A, 2022, IMMUN AGEING, V19, DOI 10.1186/s12979-022-00320-w
   Ramai D, 2021, ALIMENT PHARM THER, V53, P977, DOI 10.1111/apt.16335
   Molina VRR, 2020, PULMONOLOGY, V26, P370, DOI 10.1016/j.pulmoe.2020.05.012
   Rebane-Klemm E, 2020, CANCERS, V12, DOI 10.3390/cancers12040815
   Rezen T, 2022, CELL MOL LIFE SCI, V79, DOI 10.1007/s00018-022-04278-2
   Rigamonti AE, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph192315492
   Römer M, 2021, CLIN EXP MED, V21, P501, DOI 10.1007/s10238-021-00710-2
   Villarreal-Calderon JR, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-91393-y
   Rubinstein MM, 2021, BRIT J CANCER, V125, P495, DOI 10.1038/s41416-021-01393-y
   Ruo SW, 2021, CUREUS J MED SCIENCE, V13, DOI 10.7759/cureus.17472
   Sánchez-Jiménez F, 2019, FRONT ONCOL, V9, DOI 10.3389/fonc.2019.00596
   Schauer DP, 2023, SURG OBES RELAT DIS, V19, P530, DOI 10.1016/j.soard.2023.01.028
   Schauer DP, 2017, OBESITY, V25, pS52, DOI 10.1002/oby.22002
   Sebunova N, 2022, BMC ENDOCR DISORD, V22, DOI 10.1186/s12902-022-00942-7
   Seyfried TN, 2015, FRONT CELL DEV BIOL, V3, DOI 10.3389/fcell.2015.00043
   Sharma M, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-62272-9
   Shen J, 2020, OBES RES CLIN PRACT, V14, P548, DOI 10.1016/j.orcp.2020.10.001
   Siegel RL, 2023, CA-CANCER J CLIN, V73, P233, DOI 10.3322/caac.21772
   Silva C, 2021, EUR J PHARMACOL, V898, DOI 10.1016/j.ejphar.2021.173980
   Silva YP, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00025
   Sima E, 2019, OBES SURG, V29, P4008, DOI 10.1007/s11695-019-04089-8
   Singh D, 2017, CELL BIOSCI, V7, DOI 10.1186/s13578-017-0190-2
   Sjöholm K, 2022, DIABETES CARE, V45, P444, DOI 10.2337/dc21-1335
   Sjöström L, 2013, J INTERN MED, V273, P219, DOI 10.1111/joim.12012
   Sjöström L, 2007, NEW ENGL J MED, V357, P741, DOI 10.1056/NEJMoa066254
   Smith U, 2021, INT J OBESITY, V45, P934, DOI 10.1038/s41366-021-00757-x
   Spaander MCW, 2023, NAT REV DIS PRIMERS, V9, DOI 10.1038/s41572-023-00432-7
   Steele CB, 2017, MMWR-MORBID MORTAL W, V66, P1052, DOI 10.15585/mmwr.mm6639e1
   Stenkula KG, 2018, AM J PHYSIOL-REG I, V315, pR284, DOI 10.1152/ajpregu.00257.2017
   Stone TW, 2018, EBIOMEDICINE, V30, P14, DOI 10.1016/j.ebiom.2018.02.022
   Sui Y, 2021, FRONT CELL DEV BIOL, V9, DOI 10.3389/fcell.2021.631552
   Sung H, 2020, JAMA-J AM MED ASSOC, V324, P2521, DOI 10.1001/jama.2020.23130
   Sung H, 2021, CA-CANCER J CLIN, V71, P209, DOI 10.3322/caac.21660
   Sung H, 2019, CA-CANCER J CLIN, V69, P88, DOI 10.3322/caac.21499
   Tam SY, 2020, FRONT ONCOL, V10, DOI 10.3389/fonc.2020.00486
   Teodoro JS, 2014, GENES NUTR, V9, DOI 10.1007/s12263-014-0406-6
   Valenzuela PL, 2023, NAT REV CARDIOL, V20, P475, DOI 10.1038/s41569-023-00847-5
   Van Blarigan EL, 2018, JAMA ONCOL, V4, P783, DOI 10.1001/jamaoncol.2018.0126
   van Eijk M, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22084039
   Veettil SK, 2021, JAMA NETW OPEN, V4, DOI 10.1001/jamanetworkopen.2020.37341
   Verde L, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12010018
   Vernieri C, 2020, BREAST CANCER RES, V22, DOI 10.1186/s13058-020-01271-0
   Vicks WS, 2022, BMC PUBLIC HEALTH, V22, DOI 10.1186/s12889-022-14362-8
   Viggiani MT, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081709
   Vourdoumpa A, 2023, NUTRIENTS, V15, DOI 10.3390/nu15061416
   Wang L, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-52265-8
   Wang N, 2022, FRONT CELL INFECT MI, V12, DOI 10.3389/fcimb.2022.1029905
   Wiggins T, 2019, OBES SURG, V29, P1031, DOI 10.1007/s11695-018-3501-8
   Wilson RB, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24076192
   Wilson RB, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21114158
   Wolf PG, 2022, MSYSTEMS, V7, DOI 10.1128/msystems.01174-21
   Wong CP, 2014, J NAT MED-TOKYO, V68, P253, DOI 10.1007/s11418-014-0822-3
   Wu FY, 2022, DIABETOL METAB SYNDR, V14, DOI 10.1186/s13098-022-00947-1
   Xiang QY, 2022, BIOL REV, V97, P1844, DOI 10.1111/brv.12866
   Xiong ZC, 2022, FRONT CELL DEV BIOL, V10, DOI 10.3389/fcell.2022.818082
   Xu GZ, 2021, SURG OBES RELAT DIS, V17, P231, DOI 10.1016/j.soard.2020.08.028
   Yang YF, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051388
   Yoo HC, 2020, EXP MOL MED, V52, P1496
   Younes S, 2021, INT J OBESITY, V45, P1899, DOI 10.1038/s41366-021-00867-6
   Zahid H, 2018, INT J OBESITY, V42, P711, DOI 10.1038/ijo.2017.273
   Zbikowski A, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22147427
   Zelicha H, 2022, BMC MED, V20, DOI 10.1186/s12916-022-02525-8
   Zhang K, 2020, OBES SURG, V30, P1265, DOI 10.1007/s11695-019-04368-4
   Zhao CR, 2020, J EXP CLIN CANC RES, V39, DOI 10.1186/s13046-020-01666-z
   Zunica ERM, 2022, CANCERS, V14, DOI 10.3390/cancers14164051
NR 228
TC 27
Z9 27
U1 3
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD MAY 21
PY 2023
VL 13
IS 5
AR 675
DI 10.3390/metabo13050675
PG 46
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA H7LR7
UT WOS:000997739800001
PM 37233716
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chen, JL
   Guo, J
   Lin, CX
   Yang, JD
   Mao, P
   Jiang, S
   He, W
   Lien, K
AF Chen, Jyu-Lin
   Guo, Jia
   Lin, Chen-Xi
   Yang, Jundi
   Mao, Ping
   Jiang, Shan
   He, Wei
   Lien, Kathy
TI Behavior Characteristics and Risk for Metabolic Syndrome Among Women in
   Rural Communities in China
SO JOURNAL OF CARDIOVASCULAR NURSING
LA English
DT Article
DE BMI; menopausal; metabolic syndrome; obesity; rural China
ID ADULTS; ASSOCIATION; PREVALENCE; OBESITY; DURATION; SEX; POPULATION;
   PREVENTION; MENOPAUSE; DISEASE
AB Background Rapid economic growth and lifestyle changes in China have resulted in increased metabolic syndrome (MetS) rates. Few investigators have examined sex-specific risk factors and the role of menopause, stress, and sleep on MetS among women in China. Objective In this study, we aimed to identify the risk factors for MetS among women in rural China. Methods A cross-sectional study design was used, and participants were recruited from rural areas in China. Female participants older than 18 years were eligible to participate. Participants had their weight, height, waist circumference, blood pressure, and fasting blood measured at study sites. They also completed validated questionnaires regarding sociodemographic information and MetS-related health behaviors. Results A total of 646 women were included in this study. The overall prevalence of MetS was 26.2%. The MetS group had a greater number of overweight/obese women than the non-MetS group did. For premenopausal women, a higher income, being overweight/obese, and eating salty/marinated food increased their risk for MetS (odds ratio [OR], 2.56, 4.55, and 3.1, respectively). For postmenopausal women, a low level of education (OR, 0.44) and being overweight/obese (OR, 4.98) increased their risk of MetS. Conclusion Almost half of the women in this study were overweight/obese, and many of them did not meet the national recommendations for a healthy lifestyle, increasing their risk for MetS. Developing cultural and behavioral interventions tailored for overweight/obese women is critical in reducing MetS.
C1 [Chen, Jyu-Lin; Lien, Kathy] Univ Calif San Francisco, Sch Nursing, Dept Family Hlth Care Nursing, San Francisco, CA 94143 USA.
   [Guo, Jia; Yang, Jundi; Jiang, Shan; He, Wei] Cent South Univ, Xiangya Sch Nursing, Changsha, Peoples R China.
   [Lin, Chen-Xi] Univ Calif San Francisco, Sch Nursing, San Francisco, CA 94143 USA.
   [Mao, Ping] Cent South Univ, Xiangya Hosp 3, Nursing Dept, 138 Tongzipo Rd, Changsha 410013, Peoples R China.
   [He, Wei] Cent South Univ, Xiangya Hosp 3, Changsha, Peoples R China.
C3 University of California System; University of California San Francisco;
   Central South University; University of California System; University of
   California San Francisco; Central South University; Central South
   University
RP Mao, P (corresponding author), Cent South Univ, Xiangya Hosp 3, Nursing Dept, 138 Tongzipo Rd, Changsha 410013, Peoples R China.
EM ping.mao@csu.edu.cn
RI He, Wei/C-7426-2015; Mao, Ping/M-1505-2016; Jiang, Shan/AAR-4396-2021
OI Guo, Jia/0000-0002-8304-9947
CR Abdullah A, 2011, INT J EPIDEMIOL, V40, P985, DOI 10.1093/ije/dyr018
   Aboonabi A, 2019, J HUM HYPERTENS, V33, P844, DOI 10.1038/s41371-019-0273-0
   Ajala-Lawal RA, 2020, ARCH PHYSIOL BIOCHEM, V126, P107, DOI 10.1080/13813455.2018.1498901
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Arthur RS, 2019, CANCER CAUSE CONTROL, V30, P355, DOI 10.1007/s10552-019-01139-5
   Barros RPA, 2011, CELL METAB, V14, P289, DOI 10.1016/j.cmet.2011.08.005
   Cefalu WT, 2019, DIABETES CARE, V42, pS34, DOI 10.2337/dc19-S004
   Chuang HH, 2012, BIOFACTORS, V38, P284, DOI 10.1002/biof.1027
   Department of Disease Control Ministry of Health Republic of China, 2006, GUIDELINES PREVENTIO
   Dibaba DT, 2019, BREAST CANCER RES TR, V174, P209, DOI 10.1007/s10549-018-5056-8
   Fu SH, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-28316-x
   Ghamri RA, 2019, PAK J MED SCI, V35, P1087, DOI 10.12669/pjms.35.4.199
   Guo J, 2018, PUBLIC HEALTH NURS, V35, P18, DOI 10.1111/phn.12380
   Hakkarainen H, 2018, BMC PREGNANCY CHILDB, V18, DOI 10.1186/s12884-018-1958-z
   Hu X, 2019, ENDOCR PRACT, V25, P678, DOI 10.4158/EP-2018-0543
   Huang LN, 2020, BIOMED ENVIRON SCI, V33, P19, DOI 10.3967/bes2020.003
   Huang Q M, 2020, Zhonghua Liu Xing Bing Xue Za Zhi, V41, P190, DOI 10.3760/cma.j.issn.0254-6450.2020.02.010
   Jiang BR, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0747-z
   Krittanawong C, 2019, EUR HEART J-ACUTE CA, V8, P762, DOI 10.1177/2048872617741733
   Lan Y, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0196012
   Li L, 2012, MATURITAS, V73, P354, DOI 10.1016/j.maturitas.2012.09.008
   Li YR, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0199293
   Liu M, 2016, ARCH GERONTOL GERIAT, V63, P78, DOI 10.1016/j.archger.2015.11.003
   Liu XT, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-31336-2
   Llhua M., 2020, MEDICINE, V99
   Lu JL, 2017, J CLIN ENDOCR METAB, V102, P507, DOI 10.1210/jc.2016-2477
   Mi SJ, 2019, PEDIATR OBES, V14, DOI 10.1111/ijpo.12507
   Miranda-Lora AL, 2017, DIABETES RES CLIN PR, V126, P151, DOI 10.1016/j.diabres.2017.02.005
   Mongraw-Chaffin M, 2016, J CLIN ENDOCR METAB, V101, P4117, DOI 10.1210/jc.2016-2460
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   Mumusoglu S, 2019, CURR VASC PHARMACOL, V17, P595, DOI 10.2174/1570161116666180904094149
   Pei H L, 2020, Zhonghua Liu Xing Bing Xue Za Zhi, V41, P514, DOI 10.3760/cma.j.cn112338-20190618-00446
   Pradhan AD, 2014, CLIN CHEM, V60, P44, DOI 10.1373/clinchem.2013.202549
   Pucci G, 2017, PHARMACOL RES, V120, P34, DOI 10.1016/j.phrs.2017.03.008
   Qian YX, 2019, ENDOCRINE, V66, P240, DOI 10.1007/s12020-019-02064-y
   Ra JS, 2020, ASIAN NURS RES, V14, P173, DOI 10.1016/j.anr.2020.07.003
   Reis JP, 2013, JAMA-J AM MED ASSOC, V310, P280, DOI 10.1001/jama.2013.7833
   Ren HN, 2019, BMC ENDOCR DISORD, V19, DOI 10.1186/s12902-019-0366-3
   Shen Y, 2019, DIABETES RES CLIN PR, V150, P219, DOI 10.1016/j.diabres.2019.03.030
   Simoniene D, 2020, DIABETES THER, V11, P161, DOI 10.1007/s13300-019-00729-5
   Smiley A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112582
   Song QB, 2015, DIABETES VASC DIS RE, V12, P189, DOI 10.1177/1479164114562410
   Strait Robert B, 2018, J Child Obes, V3, DOI 10.21767/2572-5394.100048
   Strand MA, 2015, FAM MED COMMUNITY HE, V3, P15, DOI 10.15212/FMCH.2015.0106
   Suliga E, 2020, NUTRIENTS, V12, DOI 10.3390/nu12092691
   Suliga E, 2016, ANN AGR ENV MED, V23, P631, DOI 10.5604/12321966.1226858
   Tao YC, 2016, INT J ENV RES PUB HE, V13, DOI 10.3390/ijerph13080801
   Tian Y, 2018, PUBLIC HEALTH NUTR, V21, P756, DOI 10.1017/S136898001700310X
   Tu XD, 2012, SLEEP MED, V13, P1138, DOI 10.1016/j.sleep.2012.06.014
   Tyrka AR, 2012, HORM METAB RES, V44, P543, DOI 10.1055/s-0032-1306342
   Vilmi-Kerälä T, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/s13098-015-0038-z
   Vorotnikov AV, 2019, BIOCHEMISTRY-MOSCOW+, V84, P1329, DOI 10.1134/S0006297919110099
   Wang CS, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0181981
   Wang Liusen, 2019, Wei Sheng Yan Jiu, V48, P173
   Whelton PK, 2018, HYPERTENSION, V71, pE13, DOI [10.1161/HYP.0000000000000066, 10.1161/HYP.0000000000000065]
   WHO, 2011, WORLD REPORT ON DISABILITY, P1
   Wong WS, 2011, J SLEEP RES, V20, P117, DOI 10.1111/j.1365-2869.2010.00822.x
   Wu LT, 2020, BMC PUBLIC HEALTH, V20, DOI 10.1186/s12889-020-8207-x
   Xiao J, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0147062
   Xu SH, 2016, NUTRIENTS, V8, DOI 10.3390/nu8040180
   Xu YH, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0087863
   Yan H M, 2019, Zhonghua Liu Xing Bing Xue Za Zhi, V40, P284, DOI 10.3760/cma.j.issn.0254-6450.2019.03.006
   Yang GR, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/5237371
   Yang H, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0117946
   Yu WH, 2020, MENOPAUSE, V27, P216, DOI 10.1097/GME.0000000000001445
   Zhan YQ, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-921
   Zhao D, 2019, NAT REV CARDIOL, V16, P203, DOI 10.1038/s41569-018-0119-4
NR 67
TC 2
Z9 2
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0889-4655
EI 1550-5049
J9 J CARDIOVASC NURS
JI J. Cardiovasc. Nurs.
PD SEP-OCT
PY 2022
VL 37
IS 5
BP 490
EP 498
DI 10.1097/JCN.0000000000000836
PG 9
WC Cardiac & Cardiovascular Systems; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Nursing
GA 3R3LP
UT WOS:000838819000021
PM 34321435
DA 2025-06-11
ER

PT J
AU Paavola, T
   Bergmann, U
   Kuusisto, S
   Kakko, S
   Savolainen, MJ
   Salonurmi, T
AF Paavola, Timo
   Bergmann, Ulrich
   Kuusisto, Sanna
   Kakko, Sakari
   Savolainen, Markku J.
   Salonurmi, Tuire
TI Distinct Fatty Acid Compositions of HDL Phospholipids Are Characteristic
   of Metabolic Syndrome and Premature Coronary Heart Disease-Family Study
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE coronary heart disease; metabolic syndrome; HDL subfraction; lipidomics;
   phospholipid; mass spectrometry
ID HIGH-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; ARTERY-DISEASE; PLASMA;
   INFLAMMATION; CHOLESTEROL; LIPIDOME; SPHINGOMYELIN; MARKERS; SERUM
AB HDL particles can be structurally modified in atherosclerotic disorders associated with low HDL cholesterol level (HDL-C). We studied whether the lipidome of the main phosphatidylcholine (PC), lysophosphatidylcholine (LPC) and sphingomyelin (SM) species of HDL2 and HDL3 subfractions is associated with premature coronary heart disease (CHD) or metabolic syndrome (MetS) in families where common low HDL-C predisposes to premature CHD. The lipidome was analyzed by LC-MS. Lysophosphatidylcholines were depleted of linoleic acid relative to more saturated and shorter-chained acids containing species in MetS compared with non-affected subjects: the ratio of palmitic to linoleic acid was elevated by more than 30%. A minor PC (16:0/16:1) was elevated (28-40%) in MetS. The contents of oleic acid containing PCs were elevated relative to linoleic acid containing PCs in MetS; the ratio of PC (16:0/18:1) to PC (16:0/18:2) was elevated by 11-16%. Certain PC and SM ratios, e.g., PC (18:0/20:3) to PC (16:0/18:2) and a minor SM 36:2 to an abundant SM 34:1, were higher (11-36%) in MetS and CHD. The fatty acid composition of certain LPCs and PCs displayed a characteristic pattern in MetS, enriched with palmitic, palmitoleic or oleic acids relative to linoleic acid. Certain PC and SM ratios related consistently to CHD and MetS.
C1 [Paavola, Timo; Kakko, Sakari; Savolainen, Markku J.; Salonurmi, Tuire] Oulu Univ Hosp, Dept Internal Med, Res Ctr Internal Med, Oulu 90200, Finland.
   [Paavola, Timo; Kakko, Sakari; Savolainen, Markku J.; Salonurmi, Tuire] Univ Oulu, Oulu 90200, Finland.
   [Paavola, Timo; Kakko, Sakari; Savolainen, Markku J.; Salonurmi, Tuire] Oulu Univ Hosp, Med Res Ctr Oulu, Oulu 90200, Finland.
   [Bergmann, Ulrich] Univ Oulu, Bioctr Oulu, Prot Anal Core Facil, Oulu, Finland.
   [Kuusisto, Sanna] Univ Oulu, Bioctr Oulu, Fac Med, Computat Med, Oulu 90570, Finland.
   [Kuusisto, Sanna] Univ Eastern Finland, Sch Pharm, NMR Metabol Lab, Kuopio 70210, Finland.
C3 University of Oulu; University of Oulu; University of Oulu; University
   of Oulu; University of Eastern Finland
RP Salonurmi, T (corresponding author), Oulu Univ Hosp, Dept Internal Med, Res Ctr Internal Med, Oulu 90200, Finland.; Salonurmi, T (corresponding author), Univ Oulu, Oulu 90200, Finland.; Salonurmi, T (corresponding author), Oulu Univ Hosp, Med Res Ctr Oulu, Oulu 90200, Finland.
EM timo.paavola@student.oulu.fi; ulrich.bergmann@oulu.fi;
   sanna.kuusisto@uef.fi; sakari.kakko@oulu.fi; markku.savolainen@oulu.fi;
   tuire.salonurmi@oulu.fi
RI ; Salonurmi, Tuire/L-3637-2018
OI Savolainen, Markku/0000-0002-2557-6423; Kuusisto,
   Sanna/0000-0002-4468-7057; Salonurmi, Tuire/0000-0001-5104-5792
FU Sigrid Juselius Foundation; Laaketieteen lisensiaatti Paavo Ilmari
   Ahvenaisen saatio; Finnish Cultural Foundation; Finnish Foundation for
   Cardiovascular Research; Paavo Nurmi Foundation; Aarne Koskelo
   Foundation; Finnish Medical Foundation
FX This research was funded by Sigrid Juselius Foundation (to M.J.S.),
   Laaketieteen lisensiaatti Paavo Ilmari Ahvenaisen saatio (to T.P.), the
   Finnish Cultural Foundation (to T.P.), the Finnish Foundation for
   Cardiovascular Research (to M.J.S. and to T.P.), Paavo Nurmi Foundation
   (to T.P.), Aarne Koskelo Foundation (to T.P.) and the Finnish Medical
   Foundation (to T.P.).
CR Albert MA, 2005, ATHEROSCLEROSIS, V182, P193, DOI 10.1016/j.atherosclerosis.2005.05.006
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   [Anonymous], 2002, Statistical Methods for the Analysis of Repeated Measurements
   Baker PW, 2000, J LIPID RES, V41, P1261
   Bellis C, 2014, CIRC-CARDIOVASC GENE, V7, P854, DOI 10.1161/CIRCGENETICS.114.000600
   Bonora E, 2000, DIABETES CARE, V23, P57, DOI 10.2337/diacare.23.1.57
   Cardner M, 2020, JCI INSIGHT, V5, DOI 10.1172/jci.insight.131491
   Csordas A, 2008, BIOMARK INSIGHTS, V3, P127
   DAVIDSON WS, 1995, J BIOL CHEM, V270, P5882, DOI 10.1074/jbc.270.11.5882
   Denimal D, 2016, ATHEROSCLEROSIS, V246, P106, DOI 10.1016/j.atherosclerosis.2015.12.042
   Diaz SO, 2021, ANAL CHIM ACTA, V1142, P189, DOI 10.1016/j.aca.2020.10.037
   Fernandez C, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071846
   GORDON T, 1977, AM J MED, V62, P707, DOI 10.1016/0002-9343(77)90874-9
   Haase CL, 2012, J CLIN ENDOCR METAB, V97, pE248, DOI 10.1210/jc.2011-1846
   HAVEL RJ, 1955, J CLIN INVEST, V34, P1345, DOI 10.1172/JCI103182
   Herrington W, 2016, CIRC RES, V118, P535, DOI 10.1161/CIRCRESAHA.115.307611
   Holmes MV, 2015, EUR HEART J, V36, P539, DOI 10.1093/eurheartj/eht571
   Hopkins PN, 2013, PHYSIOL REV, V93, P1317, DOI 10.1152/physrev.00004.2012
   Jones PH, 2003, AM J CARDIOL, V92, P152, DOI 10.1016/S0002-9149(03)00530-7
   Kontush A, 2015, HANDB EXP PHARMACOL, V224, P3, DOI 10.1007/978-3-319-09665-0_1
   Kontush A, 2013, J LIPID RES, V54, P2950, DOI 10.1194/jlr.R036095
   Kulkarni H, 2013, LIPIDS, V48, P497, DOI 10.1007/s11745-013-3781-7
   Laurila PP, 2013, ARTERIOSCL THROM VAS, V33, P847, DOI 10.1161/ATVBAHA.112.300733
   Le Barz M, 2020, BIOCHIMIE, V169, P133, DOI 10.1016/j.biochi.2019.10.003
   LIANG HQ, 1994, J LIPID RES, V35, P1187
   Liinamaa MJ, 1997, ARTERIOSCL THROM VAS, V17, P2940, DOI 10.1161/01.ATV.17.11.2940
   Marmillot P, 2007, METABOLISM, V56, P251, DOI 10.1016/j.metabol.2006.09.021
   Meikle PJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0074341
   Meikle PJ, 2011, ARTERIOSCL THROM VAS, V31, P2723, DOI 10.1161/ATVBAHA.111.234096
   Niemi J, 2009, ANN MED, V41, P451, DOI 10.1080/07853890902893392
   Orsoni A, 2016, J LIPID RES, V57, P2073, DOI 10.1194/jlr.P068585
   Paavola T, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0171993
   Papathanasiou A, 2008, HELL J CARDIOL, V49, P72
   Perreault M, 2014, LIPIDS, V49, P255, DOI 10.1007/s11745-013-3874-3
   Pietiläinen KH, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1000623
   Pruzanski W, 2000, J LIPID RES, V41, P1035
   Rader DJ, 2014, LANCET, V384, P618, DOI 10.1016/S0140-6736(14)61217-4
   Rye KA, 1996, J BIOL CHEM, V271, P4243
   Saltiel AR, 2017, J CLIN INVEST, V127, P1, DOI [10.1172/JCI92035, 10.1172/jci92035]
   Schwab U, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002630
   Sobczak AIS, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092022
   Stadler JT, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9030242
   Ståhlman M, 2013, BBA-MOL CELL BIOL L, V1831, P1609, DOI 10.1016/j.bbalip.2013.07.009
   Sutter I, 2016, ATHEROSCLEROSIS, V246, P130, DOI 10.1016/j.atherosclerosis.2016.01.003
   Sutter I, 2015, ATHEROSCLEROSIS, V241, P539, DOI 10.1016/j.atherosclerosis.2015.05.037
   Takeda H, 2020, J PROTEOME RES, V19, P1100, DOI 10.1021/acs.jproteome.9b00602
   Voight BF, 2012, LANCET, V380, P572, DOI 10.1016/S0140-6736(12)60312-2
   Warensjö E, 2005, DIABETOLOGIA, V48, P1999, DOI 10.1007/s00125-005-1897-x
   Wonisch W, 2012, AGING MALE, V15, P159, DOI 10.3109/13685538.2012.669436
   Yancey PG, 2000, J BIOL CHEM, V275, P36596, DOI 10.1074/jbc.M006924200
   Yetukuri L, 2010, J LIPID RES, V51, P2341, DOI 10.1194/jlr.M006494
   Zannis VI, 2015, HANDB EXP PHARMACOL, V224, P53, DOI 10.1007/978-3-319-09665-0_2
   Zerrad-Saadi A, 2009, ARTERIOSCL THROM VAS, V29, P2169, DOI 10.1161/ATVBAHA.109.194555
   Zhu CH, 2019, METABOLOMICS, V15, DOI 10.1007/s11306-019-1579-1
NR 54
TC 11
Z9 11
U1 2
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAY
PY 2021
VL 22
IS 9
AR 4908
DI 10.3390/ijms22094908
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA SB9XV
UT WOS:000650338900001
PM 34066314
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tokgöz, HB
   Altan, F
AF Tokgoz, Hilal Busra
   Altan, Filiz
TI Hypericum perforatum L.: a medicinal plant with potential as a
   curative agent against obesity-associated complications
SO MOLECULAR BIOLOGY REPORTS
LA English
DT Article
DE Hypericum perforatum L; Insulin resistance; Inflammation; Obesity;
   Medicinal plants
ID HIGH-FAT-DIET; TISSUE LIPOPROTEIN-LIPASE; ADIPOSE-TISSUE;
   INSULIN-RESISTANCE; IN-VIVO; ADIPOCYTE DIFFERENTIATION;
   PHENOLIC-COMPOUNDS; GREEN TEA; EXTRACT; GENE
AB Obesity is a low-grade inflammatory disease that is getting increasingly common among adults and children and causes different complications. Insulin resistance, Type II diabetes, atherosclerosis, metabolic syndrome and hypertension are among the major health problems, that are associated with obesity. Some medications are used to treat obese individuals and metabolic surgery is recommended, if appropriate, for individuals with a BMI >= 40. Due to the fact that medications and metabolic surgery are not tolerated by all, researchers focus on alternative therapies. Medicinal plants comprise the most important group of these alternative treatments. Hypericum perforatum L. is the medicinal plant, which we focused on in this study. Hypericum perforatum L. has been recognized as a medicinally valuable plant for over 2000 years. It has been used for generations to treat anxiety, depression, insomnia, gastritis, hemorrhoids, wounds, and burns. Recent studies have indeed shown promising effects for the treatment of obesity. In this study, 3T3-L1 adipocytes were used to mimic the adipocyte differentiation associated with obesity in cellular terms. Lipoprotein lipase (Lpl), Diacylglycerol-O-acyltransferase 1 (Dgat1), Fatty acid synthase (Fasn) markers were used to study the lipid accumulation, and Collagen V (ColV) was used to study cell elasticity to investigate the relationship of the effects of the administration of Hypericum perforatum L. with obesity.
C1 [Tokgoz, Hilal Busra; Altan, Filiz] Mugla Sitki Kocman Univ, Dept Mol Biol & Genet, Fac Sci, TR-48000 Kotekli, Mugla, Turkey.
C3 Mugla Sitki Kocman University
RP Altan, F (corresponding author), Mugla Sitki Kocman Univ, Dept Mol Biol & Genet, Fac Sci, TR-48000 Kotekli, Mugla, Turkey.
EM afiliz@mu.edu.tr
RI Tokgöz, Hilal Büşra/AAX-1427-2021; ALTAN, Filiz/AAX-1445-2021
OI Tokgoz, Hilal Busra/0000-0002-0940-7427; Altan,
   Filiz/0000-0001-6358-2448
FU Scientific Resarch Project (BAP) Grant from the Mula Stk Kocman
   University [AR-GE 17/059]
FX This work was supported by the Scientific Resarch Project (BAP) Grant
   (AR-GE 17/059) from the Mula Stk Kocman University granted to Dr. Filiz
   ALTAN. Authors would like to thank to Dr. Reat uNAL for valuable
   scientific support and critical reading; to Dr. Zekiye Buket YILMAZ for
   critical reading and language editing; to Dr. Guven GoRK and Dr. Olcay
   CEYLAN for providing the plant material and to Dr. Mehmet VAROL for his
   expertise and assistance in technical editing.
CR Amini Z, 2009, BIOCHEM BIOPH RES CO, V388, P146, DOI 10.1016/j.bbrc.2009.07.137
   Arokiyaraj S., 2011, Asian Pacific Journal of Tropical Biomedicine, V1, P386, DOI 10.1016/S2221-1691(11)60085-3
   Axarlis S, 1998, PHYTOTHER RES, V12, P507, DOI 10.1002/(SICI)1099-1573(199811)12:7<507::AID-PTR370>3.0.CO;2-H
   Boizard M, 1998, J BIOL CHEM, V273, P29164, DOI 10.1074/jbc.273.44.29164
   Butterweck V, 1997, PHARMACOPSYCHIATRY, V30, P117, DOI 10.1055/s-2007-979531
   Celen Goeuel, 2008, HACETTEPE JOURNAL OF BIOLOGY AND CHEMISTRY, V36, P339
   Chen N, 2009, NUTR RES, V29, P784, DOI 10.1016/j.nutres.2009.10.003
   Dulloo AG, 2000, INT J OBESITY, V24, P252, DOI 10.1038/sj.ijo.0801101
   Gamboa-Gómez CI, 2015, EXCLI J, V14, P809, DOI 10.17179/excli2015-186
   Gray DE, 2000, J AOAC INT, V83, P944
   GREENBERG AS, 1992, CANCER RES, V52, P4113
   Harris CA, 2011, J LIPID RES, V52, P657, DOI 10.1194/jlr.M013003
   HARTMAN AD, 1981, AM J PHYSIOL, V241, pE108, DOI 10.1152/ajpendo.1981.241.2.E108
   Hatano T, 2014, BIOL PHARM BULL, V37, P1132, DOI 10.1248/bpb.b13-00989
   Hernández-Saavedra D, 2016, MED CHEM RES, V25, P163, DOI 10.1007/s00044-015-1454-1
   Hsu CL, 2009, J AGR FOOD CHEM, V57, P425, DOI 10.1021/jf802715t
   Husain Gulam Mohammed, 2011, ISRN Pharmacol, V2011, P505247, DOI 10.5402/2011/505247
   Kim SJ, 2016, J MED FOOD, V19, P353, DOI 10.1089/jmf.2015.3566
   Koc LY, 2012, BAZ BITKI EKSTRELERI
   Koren D, 2018, METABOLISM, V84, P67, DOI 10.1016/j.metabol.2018.04.001
   Malik VS, 2013, NAT REV ENDOCRINOL, V9, P13, DOI 10.1038/nrendo.2012.199
   Menegazzi M, 2008, INT J BIOCHEM CELL B, V40, P1509, DOI 10.1016/j.biocel.2007.11.019
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Pérez-Ramírez IF, 2019, EUR J LIPID SCI TECH, V121, DOI 10.1002/ejlt.201800403
   Qasim A, 2018, OBES REV, V19, P121, DOI 10.1111/obr.12625
   Raso GM, 2002, J PHARM PHARMACOL, V54, P1379, DOI 10.1211/002235702760345464
   Reichling J, 2001, PHARMACOPSYCHIATRY, V34, pS116, DOI 10.1055/s-2001-15514
   Reiter CEN, 2010, ENDOCRINOLOGY, V151, P103, DOI 10.1210/en.2009-0997
   Saddiqe Z, 2010, J ETHNOPHARMACOL, V131, P511, DOI 10.1016/j.jep.2010.07.034
   SADUR CN, 1984, J CLIN ENDOCR METAB, V59, P1176, DOI 10.1210/jcem-59-6-1176
   Spencer M, 2010, AM J PHYSIOL-ENDOC M, V299, pE1016, DOI 10.1152/ajpendo.00329.2010
   TERRETTAZ J, 1994, INT J OBESITY, V18, P9
   Tian JY, 2015, PHYTOTHER RES, V29, P86, DOI 10.1002/ptr.5230
   Wang H, 2009, AM J PHYSIOL-ENDOC M, V297, pE271, DOI 10.1152/ajpendo.90920.2008
   Ye JP, 2013, FRONT MED-PRC, V7, P14, DOI 10.1007/s11684-013-0262-6
   Yen CLE, 2008, J LIPID RES, V49, P2283, DOI 10.1194/jlr.R800018-JLR200
NR 36
TC 12
Z9 13
U1 3
U2 42
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-4851
EI 1573-4978
J9 MOL BIOL REP
JI Mol. Biol. Rep.
PD NOV
PY 2020
VL 47
IS 11
BP 8679
EP 8686
DI 10.1007/s11033-020-05912-7
EA OCT 2020
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA PB8WL
UT WOS:000581562900002
PM 33090307
DA 2025-06-11
ER

PT J
AU Chalmers, L
   Kaskel, FJ
   Bamgbola, O
AF Chalmers, Laura
   Kaskel, Fredrick J.
   Bamgbola, Oluwatoyin
TI The role of obesity and its bioclinical correlates in the progression of
   chronic kidney disease
SO ADVANCES IN CHRONIC KIDNEY DISEASE
LA English
DT Review
DE obesity; chronic kidney disease; metabolic syndrome; insulin resistance
ID BODY-MASS INDEX; MESSENGER-RNA ABUNDANCE; LOWERS BLOOD-PRESSURE;
   CHRONIC-RENAL-FAILURE; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   WEIGHT-LOSS; METABOLIC SYNDROME; GROWTH-HORMONE; PLASMA LEPTIN
AB In spite of a progressive fall in the incidence of traditional risk factors of cardiovascular morbidity (cigarette smoking, high blood pressure, and hyperlipidemia), there is an upward trend in the prevalence of obesity and chronic kidney disease (CKD). Furthermore, there is a strong correlation between body mass indices and the relative risk of progression of CKD. The close biophysiological interaction between obesity and CKD is evident by a similar occurrence of comorbidities including insulin resistance, hyperlipidermia, endothelial dysfunction, and sleep disorders. Truncal obesity is a primary component of metabolic syndrome; unlike peripheral fat, the visceral adipocytes are more resistant to insulin. In addition, lipolysis results in a release of free fatty acid and TG, whereas hypertriglycedemia is potentiated by uremic activation of fatty acid synthase. Hypertriglycedemia and low HDL cholesterol increase the relative risk of progression of CKD. Furthermore, endothelial inflammation and premature atherosclerosis are promoted by hyperhomocysteinemia and oxidation of LDL, both of which are commonly observed in CKD and obesity. Predominance of oxidative stress in both obesity and azotemia stimulate synthesis of angiotensin 11, which in turn increases TGF-B and plasminogen activator inhibitor-1, thereby propagating glomerular fibrosis. Furthermore, local synthesis of angiotensinogen by adipocytes, leptin activation of sympathetic nervous system, and hyperinsulinemia contribute to the development of hypertension in obesity and CKD. In addition, increased renal tubular expression of Na-K-ATPase and a blunted response to natiuretic hormones in obesity promote salt and water retention. Glomerular hyperfiltration from systemic volume load and hypertension results in mesangial cellular proliferation and progressive renal fibrosis. In addition, maternal nutritional deprivation increases the incidence of obesity, hypertension, and diabetes in adulthood. Reduced fetal protein synthesis contributes to oxidative glomerular injury and impairment of renal morphogenesis. Thus, kidneys are poorly equipped to handle physiologic stress that may result from the rapid body growth and programmed metabolic dysfunction later in life. Finally, in order to minimize morbidity of obesity-related kidney disease, preventive strategy must include optimal maternal health care, promotion of healthy nutrition and routine physical exercise, and early detection of CKD. (c) 2006 by the National Kidney Foundation, Inc.
C1 Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Oklahoma City, OK 73104 USA.
   Childrens Hosp Montefiore, Albert Einstein Coll Med, Dept Pediat Nephrol, Bronx, NY USA.
C3 University of Oklahoma System; University of Oklahoma Health Sciences
   Center; Montefiore Medical Center; Albert Einstein College of Medicine;
   Childrens Hospital at Montefiore; Yeshiva University
RP Bamgbola, O (corresponding author), Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, 940 NE 13th St,2B2309, Oklahoma City, OK 73104 USA.
EM Oluwatoyin-bamgbola@ouhsc.edu
CR ABRASS CK, 1988, ENDOCRINOLOGY, V123, P2432, DOI 10.1210/endo-123-5-2432
   Alexander JW, 2004, TRANSPLANTATION, V78, P469, DOI 10.1097/01.TP.0000128858.84976.27
   Annuk M, 2003, KIDNEY INT, V63, pS50, DOI 10.1046/j.1523-1755.63.s84.2.x
   Bagby SP, 2004, J AM SOC NEPHROL, V15, P2775, DOI 10.1097/01.ASN.0000141965.28037.EE
   Bamgbola FO, 2003, J RENAL NUTR, V13, P250, DOI 10.1016/S1051-2276(03)00114-6
   Bamgbola OF, 2005, PEDIATR NEPHROL, V20, P1622, DOI 10.1007/s00467-005-2021-7
   BAMGBOLA OF, 2005, GROWTH GENET HORMONE, V21, P1
   Bastard JP, 2006, EUR CYTOKINE NETW, V17, P4
   Bickel CA, 2001, AM J PHYSIOL-RENAL, V281, pF639, DOI 10.1152/ajprenal.2001.281.4.F639
   Blanco S, 2005, KIDNEY INT, V67, pS10, DOI 10.1111/j.1523-1755.2005.09303.x
   Böger RH, 1998, CIRCULATION, V98, P1842, DOI 10.1161/01.CIR.98.18.1842
   Boustany CM, 2004, AM J PHYSIOL-REG I, V287, pR943, DOI 10.1152/ajpregu.00265.2004
   Bowers CY, 2001, J CLIN ENDOCR METAB, V86, P1464, DOI 10.1210/jc.86.4.1464
   Brennan KA, 2005, REPRODUCTION, V129, P151, DOI 10.1530/rep.1.00229
   Budge H, 2004, BIOL REPROD, V71, P359, DOI 10.1095/biolreprod.103.018986
   Carroll JF, 2002, MED SCI SPORT EXER, V34, P596, DOI 10.1097/00005768-200204000-00006
   Cattaneo D, 2005, J RENAL NUTR, V15, P71, DOI 10.1053/j.jrn.2004.09.029
   Chagnac A, 2000, AM J PHYSIOL-RENAL, V278, pF817, DOI 10.1152/ajprenal.2000.278.5.F817
   Chagnac A, 2003, J AM SOC NEPHROL, V14, P1480, DOI 10.1097/01.ASN.0000068462.38661.89
   Chan CT, 2004, KIDNEY INT, V65, P661, DOI 10.1111/j.1523-1755.2004.00384.x
   Chen GP, 2001, J BIOL CHEM, V276, P49142, DOI 10.1074/jbc.M104879200
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Considine Robert V, 2005, Semin Vasc Med, V5, P15, DOI 10.1055/s-2005-871738
   Correia MLD, 2004, CURR OPIN NEPHROL HY, V13, P215, DOI 10.1097/01.mnh.0000119533.79618.b3
   Cox LA, 2006, J PHYSIOL-LONDON, V572, P67, DOI 10.1113/jphysiol.2006.106872
   Cubeddu LX, 2003, AM J HYPERTENS, V16, P343, DOI 10.1016/S0895-7061(03)00057-8
   Dandona P, 2001, J CLIN ENDOCR METAB, V86, P355, DOI 10.1210/jc.86.1.355
   de Paula RB, 2004, HYPERTENSION, V43, P41, DOI 10.1161/01.HYP.0000105624.68174.00
   Dhaun N, 2006, J AM SOC NEPHROL, V17, P943, DOI 10.1681/ASN.2005121256
   Diep QN, 2002, HYPERTENSION, V40, P866, DOI 10.1161/01.HYP.0000037969.41360.CC
   Díez N, 2005, BRIT J NUTR, V94, P204, DOI 10.1079/BJN20051468
   Dobrian AD, 2003, AM J PHYSIOL-RENAL, V285, pF619, DOI 10.1152/ajprenal.00388.2002
   Doi K, 2006, J AM SOC NEPHROL, V17, P823, DOI 10.1681/ASN.2005010094
   Drüeke TB, 2002, BLOOD PURIFICAT, V20, P494, DOI 10.1159/000065203
   Dumm NTD, 2003, INT J VITAM NUTR RES, V73, P215, DOI 10.1024/0300-9831.73.3.215
   Ehrhart-Bornstein M, 2004, ENDOCR RES, V30, P865, DOI 10.1081/ERC-200044122
   Engeli S, 2002, CURR OPIN CARDIOL, V17, P355, DOI 10.1097/00001573-200207000-00006
   Ferchland A, 1998, NEPHRON, V80, P46, DOI 10.1159/000045124
   Flegal KM, 2002, JAMA-J AM MED ASSOC, V288, P1723, DOI 10.1001/jama.288.14.1723
   Fletcher EC, 2002, J APPL PHYSIOL, V92, P627, DOI 10.1152/japplphysiol.00152.2001
   Fortuno Ana, 2005, Kidney Int Suppl, pS71
   Friedman AN, 2004, AM J KIDNEY DIS, V44, P950, DOI 10.1053/j.ajkd.2004.08.020
   Friedman AN, 2003, AM J KIDNEY DIS, V41, P480, DOI 10.1053/ajkd.2003.50059
   Fujihara CK, 2005, KIDNEY INT, V67, P1913, DOI 10.1111/j.1523-1755.2005.00290.x
   GARRISON RJ, 1987, PREV MED, V16, P235, DOI 10.1016/0091-7435(87)90087-9
   Gelber RP, 2005, AM J KIDNEY DIS, V46, P871, DOI 10.1053/j.ajkd.2005.08.015
   Geluk CA, 2005, EUR HEART J, V26, P1314, DOI 10.1093/eurheartj/ehi253
   Greco AV, 2002, DIABETES, V51, P144, DOI 10.2337/diabetes.51.1.144
   Gregg EW, 2005, JAMA-J AM MED ASSOC, V293, P1868, DOI 10.1001/jama.293.15.1868
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Grunfeld C, 1996, J CLIN INVEST, V97, P2152, DOI 10.1172/JCI118653
   Hanevold CD, 2005, PEDIATRICS, V115, P352, DOI 10.1542/peds.2004-0289
   Hanley AJG, 2003, DIABETES, V52, P2740, DOI 10.2337/diabetes.52.11.2740
   Hanly PJ, 2003, AM J KIDNEY DIS, V41, P403, DOI 10.1053/ajkd.2003.50066
   Heeschen C, 2003, BLOOD, V102, P1340, DOI 10.1182/blood-2003-01-0223
   Hsieh TJ, 2002, ENDOCRINOLOGY, V143, P2975, DOI 10.1210/en.143.8.2975
   Hsu CY, 2006, ANN INTERN MED, V144, P21, DOI 10.7326/0003-4819-144-1-200601030-00006
   Kambham N, 2001, KIDNEY INT, V59, P1498, DOI 10.1046/j.1523-1755.2001.0590041498.x
   Kanbay M, 2005, RENAL FAILURE, V27, P297, DOI 10.1081/JDI-200056610
   Kaysen GA, 2001, J AM SOC NEPHROL, V12, P1549, DOI 10.1681/ASN.V1271549
   KOPPENOL WH, 1992, CHEM RES TOXICOL, V5, P834, DOI 10.1021/tx00030a017
   Kramer H, 2005, AM J KIDNEY DIS, V46, P587, DOI 10.1053/j.ajkd.2005.06.007
   Kuo JJ, 2003, AM J PHYSIOL-REG I, V284, pR1037, DOI 10.1152/ajpregu.00480.2002
   Lee EA, 2005, KIDNEY INT, V67, P1762, DOI 10.1111/j.1523-1755.2005.00274.x
   Lewko B, 2004, KIDNEY INT, V66, P1001, DOI 10.1111/j.1523-1755.2004.00848.x
   Lohmeier TE, 2003, HYPERTENSION, V42, P96, DOI 10.1161/01.HYP.0000076092.10923.FD
   Lopes HF, 2003, HYPERTENSION, V41, P422, DOI 10.1161/01.HYP.0000053450.19998.11
   Lysaght MJ, 2002, J AM SOC NEPHROL, V13, pS37
   McCarty MF, 2004, MED HYPOTHESES, V62, P830, DOI 10.1016/j.mehy.2003.11.007
   McFarlane SI, 2001, J CLIN ENDOCR METAB, V86, P713, DOI 10.1210/jc.86.2.713
   McGregor DO, 2001, KIDNEY INT, V59, P2267, DOI 10.1046/j.1523-1755.2001.00743.x
   Mehta JL, 2001, BIOCHEM BIOPH RES CO, V289, P857, DOI 10.1006/bbrc.2001.6070
   Milstien S, 1999, BIOCHEM BIOPH RES CO, V263, P681, DOI 10.1006/bbrc.1999.1422
   Mitch WE, 2005, J CLIN INVEST, V115, P1476, DOI 10.1172/JCI25255
   MITCH WE, 2002, J AM SOC NEPHROL, V13, P22
   Morigi M, 2005, AM J PATHOL, V166, P1309, DOI 10.1016/S0002-9440(10)62350-4
   Muntner P, 2000, KIDNEY INT, V58, P293, DOI 10.1046/j.1523-1755.2000.00165.x
   O'Sullivan AJ, 2002, AM J KIDNEY DIS, V39, P369, DOI 10.1053/ajkd.2002.30558
   Oberg BP, 2004, KIDNEY INT, V65, P1009, DOI 10.1111/j.1523-1755.2004.00465.x
   Odamaki M, 1999, AM J KIDNEY DIS, V33, P361, DOI 10.1016/S0272-6386(99)70313-6
   Orth SR, 2001, NEPHROL DIAL TRANSPL, V16, P67, DOI 10.1093/ndt/16.suppl_1.67
   Öztürk L, 2003, ARCH OTOLARYNGOL, V129, P538, DOI 10.1001/archotol.129.5.538
   Petermann AT, 2002, KIDNEY INT, V61, P40, DOI 10.1046/j.1523-1755.2002.00102.x
   PRAGA M, 1995, NEPHRON, V70, P35, DOI 10.1159/000188541
   Pralong FP, 2002, FASEB J, V16, P712, DOI 10.1096/fj.01-0754fje
   Prinsen BHCMT, 2003, KIDNEY INT, V63, pS121, DOI 10.1046/j.1523-1755.63.s84.34.x
   Quaschning T, 2001, AM J KIDNEY DIS, V38, pS14, DOI 10.1053/ajkd.2001.27384
   Rahmouni K, 2002, DRUGS TODAY, V38, P807, DOI 10.1358/dot.2002.38.12.740203
   Reade EP, 2004, PEDIATR NEPHROL, V19, P1014, DOI 10.1007/s00467-004-1513-1
   Reinders MEJ, 2006, J AM SOC NEPHROL, V17, P932, DOI 10.1681/ASN.2005121250
   Ribeiro ACM, 2001, CARDIOVASC RES, V49, P697, DOI 10.1016/S0008-6363(00)00267-4
   Rodrigues CLD, 2005, AM J HYPERTENS, V18, P152, DOI 10.1016/j.amjhyper.2004.08.028
   RUTKOWSKI B, 2003, AM J KIDNEY DIS S, V41, pS48
   Schiffrin EL, 2003, HYPERTENSION, V42, P664, DOI 10.1161/01.HYP.0000084370.74777.B6
   Schneider R, 2005, AM J MED SCI, V330, P157, DOI 10.1097/00000441-200510000-00001
   Schwedler S, 2001, KIDNEY INT, V59, pS32, DOI 10.1046/j.1523-1755.2001.59780032.x
   Sharma A M, 2001, Curr Hypertens Rep, V3, P152, DOI 10.1007/s11906-001-0030-x
   Sharma K, 1997, KIDNEY INT, V51, P1980, DOI 10.1038/ki.1997.269
   Shiiya T, 2002, J CLIN ENDOCR METAB, V87, P240, DOI 10.1210/jc.87.1.240
   Shlipak MG, 2003, CIRCULATION, V107, P87, DOI 10.1161/01.CIR.0000042700.48769.59
   Srivastava T, 2006, PEDIATR NEPHROL, V21, P463, DOI 10.1007/s00467-006-0027-4
   Svatikova Anna, 2005, Curr Diab Rep, V5, P53, DOI 10.1007/s11892-005-0068-2
   Symonds ME, 2005, ADV EXP MED BIOL, V569, P24
   Tzou WS, 2005, J AM COLL CARDIOL, V46, P457, DOI 10.1016/j.jacc.2005.04.046
   Uysal O, 2005, J ENDOCRINOL INVEST, V28, P928, DOI 10.1007/BF03345325
   van der Giet M, 2002, EUR J CLIN INVEST, V32, P732, DOI 10.1046/j.1365-2362.2002.01064.x
   Vasavada N, 2003, KIDNEY INT, V64, P1772, DOI 10.1046/j.1523-1755.2003.00273.x
   Vickers MH, 2005, ENDOCRINOLOGY, V146, P4211, DOI 10.1210/en.2005-0581
   Wang MC, 2005, AM J KIDNEY DIS, V45, P494, DOI 10.1053/j.ajkd.2004.11.011
   Weisberg AD, 2005, ARTERIOSCL THROM VAS, V25, P365, DOI 10.1161/01.ATV.0000152356.85791.52
   Wolf G, 2002, AM J KIDNEY DIS, V39, P1, DOI 10.1053/ajkd.2002.29865
   Yamagishi S, 2005, DRUG EXP CLIN RES, V31, P123
   Yamauchi M, 2005, CHEST, V127, P1674, DOI 10.1378/chest.127.5.1674
   Zandi-Nejad K, 2005, MED CLIN N AM, V89, P489, DOI 10.1016/j.mcna.2004.11.001
   Zoccali C, 2001, NEPHROL DIAL TRANSPL, V16, P70, DOI 10.1093/ndt/16.1.70
NR 115
TC 73
Z9 83
U1 0
U2 16
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1548-5595
EI 1548-5609
J9 ADV CHRONIC KIDNEY D
JI Adv. Chronic Kidney Dis.
PD OCT
PY 2006
VL 13
IS 4
BP 352
EP 364
DI 10.1053/j.ackd.2006.07.010
PG 13
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 096SH
UT WOS:000241396600005
PM 17045221
DA 2025-06-11
ER

PT J
AU Morrone, D
   Picoi, MEL
   Felice, F
   De Martino, A
   Scatena, C
   Spontoni, P
   Naccarato, AG
   Di Stefano, R
   Bortolotti, U
   Dal Monte, M
   Pini, S
   Abelli, M
   Balbarini, A
AF Morrone, Doralisa
   Picoi, Maria Elena Lucia
   Felice, Francesca
   De Martino, Andrea
   Scatena, Cristian
   Spontoni, Paolo
   Naccarato, Antonio Giuseppe
   Di Stefano, Rossella
   Bortolotti, Uberto
   Dal Monte, Massimo
   Pini, Stefano
   Abelli, Marianna
   Balbarini, Alberto
TI Endothelial Progenitor Cells: An Appraisal of Relevant Data from Bench
   to Bedside
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE EPC; ischemic heart disease; progenitor cells
ID AGE-DEPENDENT IMPAIRMENT; MESENCHYMAL STEM-CELLS; CHRONIC HEART-FAILURE;
   BONE-MARROW; MYOCARDIAL-INFARCTION; METABOLIC-SYNDROME; OXIDATIVE
   STRESS; RISK; ANGIOGENESIS; MOBILIZATION
AB The mobilization of endothelial progenitor cells (EPCs) into circulation from bone marrow is well known to be present in several clinical settings, including acute coronary syndrome, heart failure, diabetes and peripheral vascular disease. The aim of this review was to explore the current literature focusing on the great opportunity that EPCs can have in terms of regenerative medicine.
C1 [Morrone, Doralisa; Picoi, Maria Elena Lucia; Felice, Francesca; Spontoni, Paolo; Di Stefano, Rossella; Balbarini, Alberto] Univ Pisa, Cardiovasc Dis Sect, Dept Surg Med & Mol Pathol & Crit Care Med, I-56100 Pisa, Italy.
   [De Martino, Andrea; Bortolotti, Uberto] Univ Pisa, Surg Sect, Dept Surg Med & Mol Pathol & Crit Care Med, I-56100 Pisa, Italy.
   [Scatena, Cristian; Naccarato, Antonio Giuseppe; Di Stefano, Rossella] Univ Pisa, Dept Translat Res & New Technol Med & Surg, I-56126 Pisa, Italy.
   [Dal Monte, Massimo] Univ Pisa, Dept Biol, I-56100 Pisa, Italy.
   [Pini, Stefano; Abelli, Marianna] Univ Pisa, Dept Clin & Expt Med, I-56100 Pisa, Italy.
C3 University of Pisa; University of Pisa; University of Pisa; University
   of Pisa; University of Pisa
RP Morrone, D; Felice, F (corresponding author), Univ Pisa, Cardiovasc Dis Sect, Dept Surg Med & Mol Pathol & Crit Care Med, I-56100 Pisa, Italy.
EM doralisa.morrone@unipi.it; picoielena@tiscali.it;
   francesca.felice@for.unipi.it; and.demartino@libero.it;
   cristian.scatena@unipi.it; paolo.spontoni@gmail.com;
   giuseppe.naccarato@med.unipi.it; rossella.distefano@unipi.it;
   uberto.bortolotti@med.unipi.it; massimo.dalmonte@unipi.it;
   stefano.pini@unipi.it; m.abelli@libero.it; a.balbarini@med.unipi.it
RI Balbarini, Alberto/G-8753-2011; Morrone, Doralisa/AAB-2223-2019; Felice,
   Francesca/C-3882-2009; De Martino, Andrea/M-6415-2019; Dal Monte,
   Massimo/AAA-9275-2022; De Martino, Andrea/H-1268-2019; SCATENA,
   CRISTIAN/K-3525-2018
OI Felice, Francesca/0000-0001-8968-2228; De Martino,
   Andrea/0000-0003-2889-4918; SCATENA, CRISTIAN/0000-0002-4862-0845;
   NACCARATO, ANTONIO GIUSEPPE/0000-0002-8195-9445
FU Fondazione CARISPEZIA
FX This research was funded by Fondazione CARISPEZIA.
CR Altabas V, 2016, MECH AGEING DEV, V159, P49, DOI 10.1016/j.mad.2016.02.009
   Anderson EM, 2017, J VASC RES, V54, P288, DOI 10.1159/000479869
   Asahara T, 1997, SCIENCE, V275, P964, DOI 10.1126/science.275.5302.964
   Balbarini A, 2007, CURR PHARM DESIGN, V13, P1699, DOI 10.2174/138161207780831329
   Berezin AE, 2016, DATA BRIEF, V8, P717, DOI 10.1016/j.dib.2016.06.015
   Blum A, 2019, QJM-INT J MED, V112, P77, DOI 10.1093/qjmed/hcx245
   Bots ML, 1997, CIRCULATION, V96, P1432, DOI 10.1161/01.CIR.96.5.1432
   Burton DGA, 2018, BIOGERONTOLOGY, V19, P447, DOI 10.1007/s10522-018-9763-7
   Carr S, 1996, J VASC SURG, V23, P755, DOI 10.1016/S0741-5214(96)70237-9
   Casamassimi A, 2007, J BIOCHEM, V141, P503, DOI 10.1093/jb/mvm060
   Case J, 2007, EXP HEMATOL, V35, P1109, DOI 10.1016/j.exphem.2007.04.002
   Chen H, 2011, DEPRESS ANXIETY, V28, P719, DOI 10.1002/da.20839
   Chen YH, 2007, DIABETES, V56, P1559, DOI 10.2337/db06-1103
   Chiang CH, 2013, CARDIOLOGY, V126, P191, DOI 10.1159/000351973
   Chironi G, 2007, ATHEROSCLEROSIS, V191, P115, DOI 10.1016/j.atherosclerosis.2006.02.041
   Chopra H, 2018, STEM CELLS INT, V2018, DOI 10.1155/2018/9847015
   de Boer HC, 2011, ARTERIOSCL THROM VAS, V31, P408, DOI 10.1161/ATVBAHA.110.216879
   De Pascale MR, 2016, INT J STEM CELLS, V9, P137, DOI 10.15283/ijsc.2016.9.1.137
   Denollet J, 2018, INT J CARDIOL, V259, P205, DOI 10.1016/j.ijcard.2018.02.064
   Di Stefano R, 2008, THROMB HAEMOSTASIS, V100, P871, DOI 10.1160/TH07-08-0509
   Di Stefano Rossella, 2002, Cardiovasc Radiat Med, V3, P172, DOI 10.1016/S1522-1865(03)00078-7
   Di Stefano R, 2014, J CARDIOVASC MED, V15, P353, DOI 10.2459/JCM.0b013e328365c195
   Dome P, 2009, MOL PSYCHIATR, V14, P523, DOI 10.1038/sj.mp.4002138
   Faber JE, 2011, ARTERIOSCL THROM VAS, V31, P1748, DOI 10.1161/ATVBAHA.111.227314
   Fadini GP, 2007, DIABETOLOGIA, V50, P2156, DOI 10.1007/s00125-007-0732-y
   Fadini GP, 2007, ATHEROSCLEROSIS, V194, P46, DOI 10.1016/j.atherosclerosis.2007.03.046
   Fadini GP, 2012, CIRC RES, V110, P624, DOI 10.1161/CIRCRESAHA.111.243386
   Fajemiroye JO, 2018, BIOMED RES INT, V2018, DOI 10.1155/2018/7156435
   Felice F, 2015, HUM PSYCHOPHARM CLIN, V30, P183, DOI 10.1002/hup.2470
   Felice F, 2013, INT J CARDIOL, V168, P621, DOI 10.1016/j.ijcard.2013.01.202
   Felice F, 2010, MICROVASC RES, V80, P332, DOI 10.1016/j.mvr.2010.05.004
   Garikipati VNS, 2017, METHODS MOL BIOL, V1553, P85, DOI 10.1007/978-1-4939-6756-8_7
   Go AS, 2014, CIRCULATION, V129, pE28, DOI 10.1161/01.cir.0000441139.02102.80
   Hare DL, 2014, EUR HEART J, V35, P1365, DOI 10.1093/eurheartj/eht462
   Heeschen C, 2003, BLOOD, V102, P1340, DOI 10.1182/blood-2003-01-0223
   Heiss C, 2005, J AM COLL CARDIOL, V45, P1441, DOI 10.1016/j.jacc.2004.12.074
   Hill JM, 2003, NEW ENGL J MED, V348, P593, DOI 10.1056/NEJMoa022287
   Hristov M, 2004, J CELL MOL MED, V8, P498, DOI 10.1111/j.1582-4934.2004.tb00474.x
   Huizer K, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184895
   Hur J, 2004, ARTERIOSCL THROM VAS, V24, P288, DOI 10.1161/01.ATV.0000114236.77009.06
   Jia GH, 2019, BBA-MOL BASIS DIS, V1865, P1802, DOI 10.1016/j.bbadis.2018.08.008
   Jialal I, 2010, ATHEROSCLEROSIS, V211, P297, DOI 10.1016/j.atherosclerosis.2010.01.036
   Jiraritthamrong C, 2012, ANN HEMATOL, V91, P311, DOI 10.1007/s00277-011-1300-6
   Keymel S, 2008, BASIC RES CARDIOL, V103, P582, DOI 10.1007/s00395-008-0742-z
   Kissel CK, 2007, J AM COLL CARDIOL, V49, P2341, DOI 10.1016/j.jacc.2007.01.095
   Kocher AA, 2001, NAT MED, V7, P430, DOI 10.1038/86498
   Koller L, 2016, THROMB HAEMOSTASIS, V116, P309, DOI 10.1160/TH16-01-0051
   Koninckx R, 2013, CARDIOVASC RES, V97, P413, DOI 10.1093/cvr/cvs427
   Kourek C, 2021, HELL J CARDIOL, V62, P70, DOI 10.1016/j.hjc.2020.03.007
   Kuki S, 2006, CIRC J, V70, P1076, DOI 10.1253/circj.70.1076
   Lara-Hernandez R, 2010, ANN VASC SURG, V24, P287, DOI 10.1016/j.avsg.2009.10.012
   Lee Poay Sian Sabrina, 2014, World J Stem Cells, V6, P355, DOI 10.4252/wjsc.v6.i3.355
   Lembo Carina, 2012, J Cardiovasc Dis Res, V3, P296, DOI 10.4103/0975-3583.102709
   Limbourg A, 2009, NAT PROTOC, V4, P1737, DOI 10.1038/nprot.2009.185
   Liu HZ, 2016, BIOMED PHARMACOTHER, V78, P101, DOI 10.1016/j.biopha.2016.01.001
   Llevadot J, 2001, J CLIN INVEST, V108, P399, DOI 10.1172/JCI200113131
   Lopez-Vilchez I, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.156
   Majumdar MK, 1998, J CELL PHYSIOL, V176, P57, DOI 10.1002/(SICI)1097-4652(199807)176:1<57::AID-JCP7>3.0.CO;2-7
   Marboeuf P, 2008, J THROMB HAEMOST, V6, P195
   Massa M, 2005, BLOOD, V105, P199, DOI 10.1182/blood-2004-05-1831
   Michelucci A, 2015, INTERN EMERG MED, V10, P329, DOI 10.1007/s11739-014-1149-5
   Misiak B, 2020, BRAIN BEHAV IMMUN, V88, P870, DOI 10.1016/j.bbi.2020.04.013
   Morrone D, 2018, INT J CARDIOL, V257, P243, DOI 10.1016/j.ijcard.2017.05.070
   Mouquet F, 2005, CIRC RES, V97, P1090, DOI 10.1161/01.RES.0000194330.66545.f5
   Murohara T, 2010, MICROVASC RES, V79, P174, DOI 10.1016/j.mvr.2010.01.008
   Nakae I, 2000, HEART VESSELS, V15, P176, DOI 10.1007/PL00007269
   Niiyama Hiroshi, 2009, J Vis Exp, DOI 10.3791/1035
   Nilsson PM, 2019, EUR J PREV CARDIOL, V26, P33, DOI 10.1177/2047487319886404
   Nygren JM, 2004, NAT MED, V10, P494, DOI 10.1038/nm1040
   Olivieri A, 1995, BONE MARROW TRANSPL, V16, P765
   Ouriel K, 2001, LANCET, V358, P1257, DOI 10.1016/S0140-6736(01)06351-6
   Palombo C, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-88
   Patry C, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0227460
   Pini S, 2014, EUR PSYCHIAT, V29, P253, DOI 10.1016/j.eurpsy.2013.06.007
   Quirici N, 2001, BRIT J HAEMATOL, V115, P186, DOI 10.1046/j.1365-2141.2001.03077.x
   Ravishankar P, 2017, JOVE-J VIS EXP, DOI 10.3791/56021
   Rosamond W, 2007, CIRCULATION, V115, pE69, DOI 10.1161/CIRCULATIONAHA.106.179918
   Ross MD, 2018, CURR CARDIOL REV, V14, P233, DOI 10.2174/1573403X14666180726112303
   Sadoun E, 2003, J HISTOCHEM CYTOCHEM, V51, P1119, DOI 10.1177/002215540305100902
   SALONEN JT, 1991, ARTERIOSCLER THROMB, V11, P1245, DOI 10.1161/01.ATV.11.5.1245
   Sandri M, 2016, EUR J PREV CARDIOL, V23, P349, DOI 10.1177/2047487315588391
   Schmidt-Lucke C, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013790
   Shintani S, 2001, CIRCULATION, V103, P2776, DOI 10.1161/hc2301.092122
   Spagnoli LG, 2004, JAMA-J AM MED ASSOC, V292, P1845, DOI 10.1001/jama.292.15.1845
   Tahhan AS, 2017, CIRC-HEART FAIL, V10, DOI 10.1161/CIRCHEARTFAILURE.117.004106
   Tan Q, 2018, CLIN LAB, V64, P1679, DOI 10.7754/Clin.Lab.2018.180427
   Tang BW, 2020, DIABETOLOGIA, V63, P1305, DOI 10.1007/s00125-020-05131-6
   Thum T, 2007, CIRC RES, V100, P434, DOI 10.1161/01.RES.0000257912.78915.af
   Torella D, 2004, AM J PHYSIOL-HEART C, V287, pH2850, DOI 10.1152/ajpheart.01119.2003
   Ungvari Z, 2018, NAT REV CARDIOL, V15, P555, DOI 10.1038/s41569-018-0030-z
   Valgimigli M, 2004, CIRCULATION, V110, P1209, DOI 10.1161/01.CIR.0000136813.89036.21
   Vasa M, 2001, CIRCULATION, V103, P2885, DOI 10.1161/hc2401.092816
   Wang RY, 2019, AGING-US, V11, P7021, DOI 10.18632/aging.102234
   Wang Y, 2006, HEART, V92, P768, DOI 10.1136/hrt.2005.069799
   Westerweel PE, 2008, EUR HEART J, V29, P2808, DOI 10.1093/eurheartj/ehn431
   Westerweel PE, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0060357
   Williamson KA, 2013, AGING CELL, V12, P139, DOI 10.1111/acel.12031
   Zhu GX, 2009, ANN VASC SURG, V23, P519, DOI 10.1016/j.avsg.2008.11.013
NR 98
TC 14
Z9 15
U1 2
U2 8
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2021
VL 22
IS 23
AR 12874
DI 10.3390/ijms222312874
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA XW0KN
UT WOS:000735319200001
PM 34884679
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chen, SJ
   Zhou, L
   Guo, QQ
   Fang, C
   Wang, MK
   Peng, XB
   Yin, JW
   Li, SZ
   Zhu, YL
   Yang, W
   Zhang, Y
   Shan, ZL
   Chen, XY
   Liu, LG
AF Chen, Sijing
   Zhou, Li
   Guo, Qianqian
   Fang, Can
   Wang, Mengke
   Peng, Xiaobo
   Yin, Jiawei
   Li, Shuzhen
   Zhu, Yalun
   Yang, Wei
   Zhang, Yan
   Shan, Zhilei
   Chen, Xiaoyi
   Liu, Liegang
TI Association of plasma chromium with metabolic syndrome among Chinese
   adults: a case-control study
SO NUTRITION JOURNAL
LA English
DT Article
DE Chromium; Metabolic syndrome; High blood glucose; Lipid
ID PICOLINATE SUPPLEMENTATION; YOUNG-ADULTS; GLUCOSE; OBESE; URINE; SERUM;
   DISEASE; STRESS; BLOOD; ZINC
AB Backgroud Chromium has been suggested playing a role in alleviating diabetes, insulin resistance and lipid anomalies, but the effect on metabolic syndrome (MetS) in humans remains controversial. Methods We conducted a matched case-control study in a Chinese population, involving 2141 MetS cases and 2141 healthy controls, which were 1:1 matched by age (+/- 2 years) and sex. Plasma chromium was measured by inductively coupled plasma mass spectrometry. Results Plasma chromium levels were lower in MetS group than in control group (mean: 4.36 mu g/L and 4.66 mu g/L, respectively,P < 0.001), and progressively decreased with the number of MetS components (Pfor trend < 0.001). After adjustment for potential confounding factors, the odds ratios (95% confidence intervals) for MetS across increasing quartiles of plasma chromium levels were 1 (reference), 0.84 (0.67-1.05), 0.76 (0.61-0.95), and 0.62 (0.49-0.78), respectively (Pfor trend < 0.001). For the components of MetS (high waist circumference, high triglycerides and high blood glucose), the odds ratios (95% confidence intervals) of the highest quartiles were 0.77 (0.61-0.95), 0.67 (0.55-0.80), and 0.53 (0.44-0.64), respectively (Pfor trend < 0.05). Conclusions Our results indicated that plasma chromium levels were inversely associated with MetS in Chinese adults. The association may be explained by the relations between plasma chromium levels and high waist circumference, and the triglycerides and blood glucose levels.
C1 [Chen, Sijing; Zhou, Li; Guo, Qianqian; Fang, Can; Wang, Mengke; Peng, Xiaobo; Yin, Jiawei; Li, Shuzhen; Zhu, Yalun; Yang, Wei; Shan, Zhilei; Liu, Liegang] Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Nutr & Food Hyg, Tongji Med Coll,Hubei Key Lab Food Nutr & Safety, Wuhan 430030, Hubei, Peoples R China.
   [Chen, Sijing; Zhou, Li; Guo, Qianqian; Fang, Can; Wang, Mengke; Peng, Xiaobo; Yin, Jiawei; Li, Shuzhen; Zhu, Yalun; Yang, Wei; Shan, Zhilei; Liu, Liegang] Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, Minist Educ,Key Lab Environm & Hlth, Wuhan 430030, Hubei, Peoples R China.
   [Zhang, Yan] Hubei Prov Key Lab Yeast Funct, Yichang 443003, Hubei, Peoples R China.
   [Chen, Xiaoyi] Guangzhou Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Guangzhou 511436, Peoples R China.
C3 Huazhong University of Science & Technology; Ministry of Education -
   China; Huazhong University of Science & Technology; Guangzhou Medical
   University
RP Liu, LG (corresponding author), Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Nutr & Food Hyg, Tongji Med Coll,Hubei Key Lab Food Nutr & Safety, Wuhan 430030, Hubei, Peoples R China.; Chen, XY (corresponding author), Guangzhou Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Guangzhou 511436, Peoples R China.
EM wwchenxy1@163.com; lgliu@mails.tjmu.edu.cn
RI Shan, Zhilei/S-5189-2019; Chen, Xiaoyi/AAH-6605-2020; guo,
   Qianqian/MGT-0524-2025; wang, mk/JEP-6109-2023; Yin,
   Jiawei/MGV-1674-2025
FU National Natural Science Foundation of China [81803239]; Major
   International (Regional) Joint Research Project [81820108027];
   Fundamental Research Funds for the Central Universities
   [2019kfyXMBZ050]; Angel Nutrition Research Fund
FX This study was supported by the National Natural Science Foundation of
   China (81803239); the Major International (Regional) Joint Research
   Project (81820108027); the Fundamental Research Funds for the Central
   Universities (2019kfyXMBZ050); and the Angel Nutrition Research Fund.
CR Aguilar V, 2007, ANN NUTR METAB, V51, P402, DOI 10.1159/000108108
   ANDERSON RA, 1992, BIOL TRACE ELEM RES, V32, P117, DOI 10.1007/BF02784595
   Bai JL, 2015, SCI REP-UK, V5, DOI 10.1038/srep15606
   Balk EM, 2007, DIABETES CARE, V30, P2154, DOI 10.2337/dc06-0996
   Basaki M, 2012, BIOL TRACE ELEM RES, V148, P161, DOI 10.1007/s12011-012-9360-6
   BRUNE D, 1993, SCAND J WORK ENV HEA, V19, P39
   Cefalu WT, 2004, DIABETES CARE, V27, P2741, DOI 10.2337/diacare.27.11.2741
   Cefalu WT, 2002, J NUTR, V132, P1107, DOI 10.1093/jn/132.6.1107
   Chen GL, 2006, MOL ENDOCRINOL, V20, P857, DOI 10.1210/me.2005-0255
   Chen S, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030294
   Cheng HG, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0087753
   Ding WJ, 1998, BIOL TRACE ELEM RES, V63, P231, DOI 10.1007/BF02778941
   Eckel RH, 2010, LANCET, V375, P181, DOI 10.1016/S0140-6736(09)61794-3
   Farshchi A, 2013, J PHARM PHARM SCI, V16, P99, DOI 10.18433/J3G022
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Guallar E, 2005, AM J EPIDEMIOL, V162, P157, DOI 10.1093/aje/kwi180
   Iqbal N, 2009, METAB SYNDR RELAT D, V7, P143, DOI 10.1089/met.2008.0048
   Iyengar G. Venkatesh, 2002, Food and Nutrition Bulletin, V23, P124
   Jain SK, 2007, FREE RADICAL BIO MED, V43, P1124, DOI 10.1016/j.freeradbiomed.2007.05.019
   Lin CC, 2016, CLIN NUTR, V35, P880, DOI 10.1016/j.clnu.2015.05.022
   Lu JL, 2017, J CLIN ENDOCR METAB, V102, P507, DOI 10.1210/jc.2016-2477
   Martin J, 2006, DIABETES CARE, V29, P1826, DOI 10.2337/dc06-0254
   MINOIA C, 1988, SCI TOTAL ENVIRON, V71, P323, DOI 10.1016/0048-9697(88)90204-5
   Morris BW, 1999, J TRACE ELEM MED BIO, V13, P57, DOI 10.1016/S0946-672X(99)80024-8
   Nussbaumerova B, 2018, BIOL TRACE ELEM RES, V183, P192, DOI 10.1007/s12011-017-1128-6
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Sharma S, 2011, J TRACE ELEM MED BIO, V25, P149, DOI 10.1016/j.jtemb.2011.03.003
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Son J, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15040682
   Song FF, 2007, CLIN SCI, V112, P599, DOI 10.1042/CS20060323
   Sreejayan N, 2008, OBESITY, V16, P1331, DOI 10.1038/oby.2008.217
   Tian HL, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010063.pub2
   Tuzcu M, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-28
   Wang H, 2005, BIOCHEMISTRY-US, V44, P8167, DOI 10.1021/bi0473152
   Wang ZQ, 2006, J NUTR, V136, P415, DOI 10.1093/jn/136.2.415
   Wilson PWF, 2005, CIRCULATION, V112, P3066, DOI 10.1161/CIRCULATIONAHA.105.539528
   Yang XP, 2006, J INORG BIOCHEM, V100, P1187, DOI 10.1016/j.jinorgbio.2006.01.039
   Zhang Q, 2017, BIOSCIENCE REP, V37, DOI 10.1042/BSR20160362
   Zhao P, 2009, BIOCHEM PHARMACOL, V77, P1002, DOI 10.1016/j.bcp.2008.11.018
NR 39
TC 6
Z9 6
U1 4
U2 14
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2891
J9 NUTR J
JI Nutr. J.
PD SEP 23
PY 2020
VL 19
IS 1
AR 107
DI 10.1186/s12937-020-00625-w
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA NV9JO
UT WOS:000574628400001
PM 32967680
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Mohammadi, A
   Sadeghnia, HR
   Saberi-Karimian, M
   Safarian, H
   Ferns, GA
   Ghayour-Mobarhan, M
   Sahebkar, A
AF Mohammadi, Akram
   Sadeghnia, Hamid Reza
   Saberi-Karimian, Maryam
   Safarian, Hamideh
   Ferns, Gordon A.
   Ghayour-Mobarhan, Majid
   Sahebkar, Amirhossein
TI Effects of Curcumin on Serum Vitamin E Concentrations in Individuals
   with Metabolic Syndrome
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE metabolic syndrome; vitamin E; curcuminoids; turmeric
ID RANDOMIZED CONTROLLED-TRIAL; CLINICAL-PRACTICE; OBESE INDIVIDUALS;
   OXIDATIVE STRESS; METAANALYSIS; TOCOPHEROL; MORTALITY; OSTEOARTHRITIS;
   THERAPY; MEN
AB Vitamin E is an important lipid-soluble antioxidant. The aim of the present study was to investigate the effect of curcumin on serum vitamin E levels in subjects with metabolic syndrome (MetS). A total of 120 subjects aged 18-65 years old with MetS were recruited in this study according to the International Diabetic Federation Criteria. Included subjects were randomized into three groups: subjects receiving lecithinized curcumin (1 g/day equivalent to 200-mg pure curcumin per day) for a period of 6 weeks) n = 40), patients receiving unformulated curcumin (1 g/day) for a period of 6 weeks) n = 40) and a control group receiving placebo for the same period (n = 40). Vitamin E was determined in all patients before and after the intervention using high-performance liquid chromatography method. Results showed that curcumin has no improving effect on serum levels of vitamin E (p > 0.05). There were significant differences between pre-trial and post-trial levels of vitamin E/low-density lipoprotein cholesterol ratio (p < 0.05), vitamin E/high-density lipoprotein cholesterol ratio (p < 0.05), vitamin E/total cholesterol ratio (p < 0.01) and vitamin E/triglyceride ratio (p < 0.05) between the three groups of the study. Results of the present study did not suggest any improving effect of curcumin supplementation on serum vitamin E concentrations in subjects with MetS. Copyright (C) 2017 John Wiley & Sons, Ltd.
C1 [Mohammadi, Akram] Mashhad Univ Med Sci, Sch Med, Dept Modern Sci & Technol, Mashhad, Iran.
   [Sadeghnia, Hamid Reza] Mashhad Univ Med Sci, Sch Med, Dept Pharmacol, Mashhad, Iran.
   [Saberi-Karimian, Maryam] Mashhad Univ Med Sci, Sch Med, Dept Modern Sci & Technol, Student Res Comm, Mashhad, Iran.
   [Safarian, Hamideh] Mashhad Univ Med Sci, Sch Med, Dept Biochem, Mashhad, Iran.
   [Ferns, Gordon A.] Brighton & Sussex Med Sch, Div Med Educ, Brighton BN1 9PH, Sussex, England.
   [Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Sch Med, Biochem & Nutr Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences; University of Sussex; University of Brighton; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences
RP Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Sch Med, Biochem & Nutr Res Ctr, Mashhad, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci ences, Sch Med, Dept Biotechnol, Mashhad, Iran.
EM ghayourm@mums.ac.ir; sahebkara@mums.ac.ir
RI Sadeghnia, Hamid/AAA-9820-2019; Ghayour-Mobarhan, Majid/AAY-5963-2020;
   Sahebkar, Amirhossein/B-5124-2018
OI Sadeghnia, Hamid Reza/0000-0002-3228-6897
FU Mashhad University of Medical Sciences (MUMS)
FX We frankly thank all the patients who volunteered to participate in this
   study. Also, the authors would like to thank Mashhad University of
   Medical Sciences (MUMS) for the financial support. A. M., H. R. S., M.
   G.-M. and A. S. contributed in the conception and design of the study,
   acquisition of data, interpretation of data, revising the draft and
   approval of the final version of the manuscript. M. S.-K. contributed in
   the acquisition of data, analysis and interpretation of data, revising
   the draft and approval of the final version of the manuscript. H. S.
   contributed in the acquisition of data. G. A. F. contributed in the
   interpretation of data, revising the draft and approval of the final
   version of the manuscript.
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Biswas J, 2010, HUM EXP TOXICOL, V29, P513, DOI 10.1177/0960327109359020
   Derosa G, 2016, PHARMACOL RES, V111, P394, DOI 10.1016/j.phrs.2016.07.004
   DiSilvestro RA, 2012, NUTR J, V11, DOI 10.1186/1475-2891-11-79
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Esmaily H, 2015, CHIN J INTEGR MED, V21, P332, DOI 10.1007/s11655-015-2160-z
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Hadi SM, 2000, IUBMB LIFE, V50, P167, DOI 10.1080/152165400300001471
   Hu G, 2004, ARCH INTERN MED, V164, P1066, DOI 10.1001/archinte.164.10.1066
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Kamal-Eldin A, 2000, LIPIDS, V35, P427, DOI 10.1007/s11745-000-541-y
   Karimian MS, 2017, CYTOKINE GROWTH F R, V33, P55, DOI 10.1016/j.cytogfr.2016.10.001
   KITAGAWA M, 1989, J NUTR SCI VITAMINOL, V35, P133, DOI 10.3177/jnsv.35.133
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Mardones P, 2002, J NUTR, V132, P443, DOI 10.1093/jn/132.3.443
   MEISTER A, 1994, J BIOL CHEM, V269, P9397
   Miquel J, 2002, ARCH GERONTOL GERIAT, V34, P37, DOI 10.1016/S0167-4943(01)00194-7
   Mirzaei H, 2016, INT J CANCER, V139, P1683, DOI 10.1002/ijc.30224
   Mohammadi A, 2013, PHYTOTHER RES, V27, P374, DOI 10.1002/ptr.4715
   Momtazi AA, 2016, REV PHYSIOL BIOCH P, V171, P1, DOI 10.1007/112_2016_3
   Panahi Y, 2015, J DIET S, P17
   Panahi Yunes, 2016, Journal of Dietary Supplements, V13, P209, DOI 10.3109/19390211.2015.1008611
   Panahi Y, 2015, PHYTOTHER RES, V29, P17, DOI 10.1002/ptr.5211
   Panahi Y, 2014, COMPLEMENT THER MED, V22, P851, DOI 10.1016/j.ctim.2014.07.006
   Panahi Y, 2014, PHYTOTHER RES, V28, P1625, DOI 10.1002/ptr.5174
   Panahi Y, 2012, ANN CLIN BIOCHEM, V49, P580, DOI 10.1258/acb.2012.012040
   Papas A, 2003, BRIT J NUTR, V89, P83, DOI 10.1079/BJN2002751
   Sahebkar A, 2016, PAIN MED, V17, P1192, DOI 10.1093/pm/pnv024
   Sahebkar A, 2016, PHARMACOL RES, V107, P234, DOI 10.1016/j.phrs.2016.03.026
   Sahebkar A, 2014, PHYTOTHER RES, V28, P633, DOI 10.1002/ptr.5045
   Sahebkar A, 2014, NAT REV CARDIOL, V11, P123, DOI 10.1038/nrcardio.2013.140-c1
   Sahebkar A, 2013, PHYTOTHER RES, V27, P1883, DOI 10.1002/ptr.4952
   Sahebkar A, 2013, BIOFACTORS, V39, P197, DOI 10.1002/biof.1062
   Sahebkar A, 2010, FERTIL STERIL, V94, pE75, DOI 10.1016/j.fertnstert.2010.07.1071
   Sahoo DK, 2008, CHEM-BIOL INTERACT, V176, P121, DOI 10.1016/j.cbi.2008.07.009
   Sen Gupta R, 2004, MOL CELLS, V17, P132
NR 36
TC 23
Z9 23
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD APR
PY 2017
VL 31
IS 4
BP 657
EP 662
DI 10.1002/ptr.5779
PG 6
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA ER2DM
UT WOS:000398604300011
PM 28198120
OA Bronze
DA 2025-06-11
ER

PT J
AU Vanni, E
   Marengo, A
   Mezzabotta, L
   Bugianesi, E
AF Vanni, Ester
   Marengo, Andrea
   Mezzabotta, Lavinia
   Bugianesi, Elisabetta
TI Systemic Complications of Nonalcoholic Fatty Liver Disease: When the
   Liver Is Not an Innocent Bystander
SO SEMINARS IN LIVER DISEASE
LA English
DT Review
DE nonalcoholic fatty liver disease; metabolic syndrome; cardiovascular
   disease; type 2 diabetes mellitus; colorectal cancer; chronic kidney
   disease
ID CHRONIC KIDNEY-DISEASE; GAMMA-GLUTAMYL-TRANSFERASE; TYPE-2
   DIABETIC-PATIENTS; LEFT-VENTRICULAR FUNCTION; INDEPENDENT RISK-FACTOR;
   CORONARY-HEART-DISEASE; TERM-FOLLOW-UP; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME
AB The top three leading causes of death in patients with nonalcoholic fatty liver disease (NAFLD) in descending order are cardiovascular disease, cancer, and liver disease. It is clear now that the increased risk of metabolic and macro-and microvascular complications in NAFLD stems from the associated features of metabolic syndrome. However, NAFLD itself may contribute to the spectrum of risk factors associated with insulin resistance. The primary focus of this review is to summarize the main systemic associations of NAFLD, as well as to discuss the mechanisms that link them to NAFLD. Hepatic lipid accumulation in NAFLD impairs hepatic glucose and lipid metabolism further increasing the risk of type 2 diabetes mellitus and of cardiovascular disease, independently of established risk factors. The incidence, prevalence, and severity of these complications are proportional to the histological severity of liver damage suggesting that NAFLD, but particularly nonalcoholic steatohepatitis, can also contribute to the low-grade inflammatory state through the systemic release of several markers of inflammation, oxidative stress, and of procoagulant factors. The clinical implication of these findings is that patients with NAFLD require a multidisciplinary evaluation, with a major focus on type 2 diabetes mellitus and cardiovascular disease complications and may benefit from more intensive surveillance and early treatment interventions to decrease the risk for cardiovascular and kidney complications.
C1 [Vanni, Ester; Marengo, Andrea; Mezzabotta, Lavinia; Bugianesi, Elisabetta] Univ Torino, AO Citta Salute & Sci Torino, Dept Med Sci, Div Gastrohepatol, I-10126 Turin, Italy.
C3 University of Turin; A.O.U. Citta della Salute e della Scienza di Torino
RP Bugianesi, E (corresponding author), Univ Torino, AO Citta Salute & Sci Torino, Dept Med Sci, Div Gastroenterol & Hepatol, Corso Bramante 88, I-10126 Turin, Italy.
EM elisabetta.bugianesi@unito.it
RI Bugianesi, Elisabetta/K-8008-2016
FU European Union [634413]
FX The authors are members of the EPoS (Elucidating Pathways of
   Steatohepatitis) consortium funded by the Horizon 2020 Framework Program
   of the European Union under Grant Agreement 634413.
CR Adams LA, 2005, GASTROENTEROLOGY, V129, P113, DOI 10.1053/j.gastro.2005.04.014
   Ahn AL, 2013, KOREAN J FAM MED, V34, P199, DOI 10.4082/kjfm.2013.34.3.199
   Amar J, 2008, AM J CLIN NUTR, V87, P1219, DOI 10.1093/ajcn/87.5.1219
   Angulo P, 2002, NEW ENGL J MED, V346, P1221, DOI 10.1038/nrdp.2015.80
   Angulo P, 2010, HEPATOLOGY, V51, P373, DOI 10.1002/hep.23521
   Anstee QM, 2013, NAT REV GASTRO HEPAT, V10, P330, DOI 10.1038/nrgastro.2013.41
   Arase Y, 2011, INTERNAL MED, V50, P1081, DOI 10.2169/internalmedicine.50.5043
   Armstrong MJ, 2014, HEPATOLOGY, V59, P1174, DOI 10.1002/hep.26717
   Athyros VG, 2010, LANCET, V376, P1916, DOI 10.1016/S0140-6736(10)61272-X
   Bae JC, 2011, DIABETES CARE, V34, P727, DOI 10.2337/dc10-1991
   Balkau B, 2010, BMC GASTROENTEROL, V10, DOI 10.1186/1471-230X-10-56
   Bråkenhielm E, 2004, P NATL ACAD SCI USA, V101, P2476, DOI 10.1073/pnas.0308671100
   Browning JD, 2004, HEPATOLOGY, V40, P1387, DOI 10.1002/hep.20466
   Bugianesi E, 2005, DIABETOLOGIA, V48, P634, DOI 10.1007/s00125-005-1682-x
   Bugianesi E, 2005, HEPATOLOGY, V42, P987, DOI 10.1002/hep.20920
   Bugianesi E, 2012, HEART FAIL CLIN, V8, P663, DOI 10.1016/j.hfc.2012.06.010
   Chang Y, 2008, METABOLISM, V57, P569, DOI 10.1016/j.metabol.2007.11.022
   Chang Y, 2013, AM J GASTROENTEROL, V108, P1861, DOI 10.1038/ajg.2013.349
   Chen LY, 2012, WORLD J GASTROENTERO, V18, P4215, DOI 10.3748/wjg.v18.i31.4215
   Chiu HM, 2007, CLIN GASTROENTEROL H, V5, P221, DOI 10.1016/j.cgh.2006.06.022
   Dam-Larsen S, 2004, GUT, V53, P750, DOI 10.1136/gut.2003.019984
   de Marco R, 1999, DIABETES CARE, V22, P756, DOI 10.2337/diacare.22.5.756
   Dhingra R, 2010, ARTERIOSCL THROM VAS, V30, P1855, DOI 10.1161/ATVBAHA.110.207340
   Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI23621
   Ekstedt M, 2006, HEPATOLOGY, V44, P865, DOI 10.1002/hep.21327
   Fabbrini E, 2008, GASTROENTEROLOGY, V134, P424, DOI 10.1053/j.gastro.2007.11.038
   Fan JG, 2007, J GASTROEN HEPATOL, V22, P1086, DOI 10.1111/j.1440-1746.2006.04781.x
   Fintini D, 2014, NUTR METAB CARDIOVAS, V24, P72, DOI 10.1016/j.numecd.2013.06.005
   Fragasso G, 2006, EUR HEART J, V27, P942, DOI 10.1093/eurheartj/ehi816
   Fraser A, 2007, ARTERIOSCL THROM VAS, V27, P2729, DOI 10.1161/ATVBAHA.107.152298
   Fraser A, 2009, DIABETES CARE, V32, P741, DOI 10.2337/dc08-1870
   Gastaldelli A, 2009, HEPATOLOGY, V49, P1537, DOI 10.1002/hep.22845
   Hamaguchi M, 2007, WORLD J GASTROENTERO, V13, P1579, DOI 10.3748/wjg.v13.i10.1579
   Haring R, 2009, HEPATOLOGY, V50, P1403, DOI 10.1002/hep.23135
   Henao-Mejia J, 2012, NATURE, V482, P179, DOI 10.1038/nature10809
   Hossain N, 2011, SCAND J GASTROENTERO, V46, P479, DOI 10.3109/00365521.2010.539251
   Huang KW, 2013, COLORECTAL DIS, V15, P830, DOI 10.1111/codi.12172
   Hui JM, 2004, HEPATOLOGY, V40, P46, DOI 10.1002/hep.20280
   Hwang ST, 2010, INTERN MED J, V40, P437, DOI 10.1111/j.1445-5994.2009.01979.x
   Kim AY, 2010, MOL ENDOCRINOL, V24, P1441, DOI 10.1210/me.2009-0498
   Kim CH, 2008, DIABETIC MED, V25, P476, DOI 10.1111/j.1464-5491.2008.02410.x
   Kim D, 2013, HEPATOLOGY, V57, P1357, DOI 10.1002/hep.26156
   Kim NH, 2014, HEART, V100, P938, DOI 10.1136/heartjnl-2013-305099
   Lautamäki R, 2006, AM J PHYSIOL-ENDOC M, V291, pE282, DOI 10.1152/ajpendo.00604.2005
   Lazo M, 2011, BMJ-BRIT MED J, V343, DOI 10.1136/bmj.d6891
   Lee YI, 2012, J GASTROEN HEPATOL, V27, P91, DOI 10.1111/j.1440-1746.2011.06816.x
   Li GL, 2012, BIOCHEM MEDICA, V22, P92
   Li YQ, 2014, INT UROL NEPHROL, V46, P1785, DOI 10.1007/s11255-014-0796-9
   Lorenzo C, 2013, DIABETOLOGIA, V56, P746, DOI 10.1007/s00125-012-2826-4
   Louis P, 2014, NAT REV MICROBIOL, V12, P661, DOI 10.1038/nrmicro3344
   Machado MV, 2012, LIVER INT, V32, P241, DOI 10.1111/j.1478-3231.2011.02623.x
   Matteoni CA, 1999, GASTROENTEROLOGY, V116, P1413, DOI 10.1016/S0016-5085(99)70506-8
   Mehal WZ, 2013, NAT REV GASTRO HEPAT, V10, P637, DOI 10.1038/nrgastro.2013.146
   Moon SH, 2015, ANGIOLOGY, V66, P472, DOI 10.1177/0003319714537872
   Morris EM, 2013, MOL CELL ENDOCRINOL, V378, P29, DOI 10.1016/j.mce.2012.04.013
   Musso G, 2014, PLOS MED, V11, DOI 10.1371/journal.pmed.1001680
   Musso G, 2011, ANN MED, V43, P617, DOI 10.3109/07853890.2010.518623
   Okamoto M, 2003, J EPIDEMIOL, V13, P15, DOI 10.2188/jea.13.15
   Oni ET, 2013, ATHEROSCLEROSIS, V230, P258, DOI 10.1016/j.atherosclerosis.2013.07.052
   Pacifico L, 2014, HEPATOLOGY, V59, P461, DOI 10.1002/hep.26610
   Park SK, 2013, HEPATOLOGY, V57, P1378, DOI 10.1002/hep.26183
   Perseghin G, 2008, HEPATOLOGY, V47, P51, DOI 10.1002/hep.21983
   Perseghin G, 2009, DIABETES CARE, V32, pS164, DOI 10.2337/dc09-S303
   Pittas AG, 2004, J CLIN ENDOCR METAB, V89, P447, DOI 10.1210/jc.2003-031005
   Rafiq N, 2009, CLIN GASTROENTEROL H, V7, P234, DOI 10.1016/j.cgh.2008.11.005
   Reaven GM, 2005, CLIN CHEM, V51, P931, DOI 10.1373/clinchem.2005.048611
   Ricci C, 1997, J HEPATOL, V27, P108, DOI 10.1016/S0168-8278(97)80288-7
   Rijzewijk LJ, 2010, J AM COLL CARDIOL, V56, P225, DOI 10.1016/j.jacc.2010.02.049
   Ryysy L, 2000, DIABETES, V49, P749, DOI 10.2337/diabetes.49.5.749
   Schindhelm RK, 2007, ATHEROSCLEROSIS, V191, P391, DOI 10.1016/j.atherosclerosis.2006.04.006
   Seppälä-Lindroos A, 2002, J CLIN ENDOCR METAB, V87, P3023, DOI 10.1210/jc.87.7.3023
   Sert A, 2013, AM J CARDIOL, V112, P436, DOI 10.1016/j.amjcard.2013.03.056
   Shibata M, 2007, DIABETES CARE, V30, P2940, DOI 10.2337/dc07-0792
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Shulman GI, 2014, NEW ENGL J MED, V371, P1131, DOI 10.1056/NEJMra1011035
   Siddiqui MS, 2013, GASTROENTEROLOGY, V145, P1271, DOI 10.1053/j.gastro.2013.08.036
   Simmons RK, 2010, DIABETOLOGIA, V53, P600, DOI 10.1007/s00125-009-1620-4
   Singh GK, 2013, J PEDIATR-US, V162, P1160, DOI 10.1016/j.jpeds.2012.11.024
   Sirota JC, 2012, AM J NEPHROL, V36, P466, DOI 10.1159/000343885
   Söderberg C, 2010, HEPATOLOGY, V51, P595, DOI 10.1002/hep.23314
   Stadlmayr A, 2011, J INTERN MED, V270, P41, DOI 10.1111/j.1365-2796.2011.02377.x
   Stepanova M, 2012, CLIN GASTROENTEROL H, V10, P646, DOI 10.1016/j.cgh.2011.12.039
   Sung KC, 2013, J CLIN ENDOCR METAB, V98, P3637, DOI 10.1210/jc.2013-1519
   Sung KC, 2012, DIABETES CARE, V35, P717, DOI 10.2337/dc11-1853
   Targher G, 2008, DIABETOLOGIA, V51, P444, DOI 10.1007/s00125-007-0897-4
   Targher G, 2010, NUTR METAB CARDIOVAS, V20, P583, DOI 10.1016/j.numecd.2009.05.012
   Targher G, 2008, J AM SOC NEPHROL, V19, P1564, DOI 10.1681/ASN.2007101155
   Targher G, 2007, DIABETES CARE, V30, P1212, DOI 10.2337/dc06-2247
   Targher G, 2014, DIABETES CARE, V37, P1729, DOI 10.2337/dc13-2704
   Targher G, 2010, CLIN J AM SOC NEPHRO, V5, P2166, DOI 10.2215/CJN.05050610
   Targher G, 2010, NEW ENGL J MED, V363, P1341, DOI 10.1056/NEJMra0912063
   Tilg H, 2011, GUT, V60, P745, DOI 10.1136/gut.2011.239392
   Touzin Nadege T, 2011, Therap Adv Gastroenterol, V4, P169, DOI 10.1177/1756283X11402118
   Vassilatou E, 2014, WORLD J GASTROENTERO, V20, P8351, DOI 10.3748/wjg.v20.i26.8351
   Wannamethee SG, 2012, ARTERIOSCL THROM VAS, V32, P830, DOI 10.1161/ATVBAHA.111.240457
   Wong VWS, 2011, GUT, V60, P1721, DOI 10.1136/gut.2011.242016
   Wong VWS, 2011, GUT, V60, P829, DOI 10.1136/gut.2011.237974
   Yamada T, 2010, J GASTROEN HEPATOL, V25, P352, DOI 10.1111/j.1440-1746.2009.05998.x
   Yasui K, 2011, METABOLISM, V60, P735, DOI 10.1016/j.metabol.2010.07.022
   Yilmaz Y, 2010, METABOLISM, V59, P1327, DOI 10.1016/j.metabol.2009.12.012
   Zhou YJ, 2012, J DIGEST DIS, V13, P153, DOI 10.1111/j.1751-2980.2011.00571.x
NR 101
TC 65
Z9 67
U1 1
U2 13
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0272-8087
EI 1098-8971
J9 SEMIN LIVER DIS
JI Semin. Liver Dis.
PD AUG
PY 2015
VL 35
IS 3
BP 236
EP 249
DI 10.1055/s-0035-1562944
PG 14
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA CR6ZX
UT WOS:000361498200004
PM 26378641
DA 2025-06-11
ER

PT J
AU Cruz-Teno, C
   Pérez-Martínez, P
   Delgado-Lista, J
   Yubero-Serrano, EM
   García-Ríos, A
   Marín, C
   Gómez, P
   Jiménez-Gómez, Y
   Camargo, A
   Rodríguez-Cantalejo, F
   Malagón, MM
   Pérez-Jiménez, F
   Roche, HM
   López-Miranda, J
AF Cruz-Teno, Cristina
   Perez-Martinez, Pablo
   Delgado-Lista, Javier
   Yubero-Serrano, Elena M.
   Garcia-Rios, Antonio
   Marin, Carmen
   Gomez, Purificacion
   Jimenez-Gomez, Yolanda
   Camargo, Antonio
   Rodriguez-Cantalejo, Fernando
   Malagon, Maria M.
   Perez-Jimenez, Francisco
   Roche, Helen M.
   Lopez-Miranda, Jose
TI Dietary fat modifies the postprandial inflammatory state in subjects
   with metabolic syndrome: the LIPGENE study
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Metabolic syndrome; Inflammation; NF-kB; Postprandial state;
   Monounsaturated fatty acids
ID NF-KAPPA-B; BLOOD MONONUCLEAR-CELLS; NECROSIS-FACTOR-ALPHA;
   ADIPOSE-TISSUE; OXIDATIVE STRESS; WEIGHT-LOSS; ACTIVATION; EXPRESSION;
   OBESE; ENDOTHELIUM
AB Scope: Our aim was to investigate whether the inflammatory state associated to metabolic syndrome (MetS) patients is affected by diets with different fat quality and quantity.
   Methods and results: Seventy-five subjects from LIPGENE cohort were included in this feeding trial and randomly assigned to one of four diets: high saturated fatty acids (HSFA); high monounsaturated fatty acids (HMUFA) and two low-fat, high complex carbohydrate (LFHCC) diets, supplemented with long-chain n-3 polyunsaturated fatty acids (LFHCC n-3) or placebo (LFHCC), for 12 weeks each. A postprandial fat challenge, reflecting the intervention dietary fat composition, was conducted post-intervention. The HMUFA diet significantly reduced postprandial nuclear transcription factor-kappaB (NF-kB) activity and the nuclear p65 protein levels relative to fasting values (p < 0.05). Furthermore, we observed a postprandial decrease in this protein with the HMUFA diet compared with the HSFA and LFHCC diets (p < 0.05). The postprandial response of inhibitory molecule from NF-kB mRNA levels increased with the HMUFA diet compared with the HSFA and LFHCC n-3 diets (p < 0.05). Postprandial tumor necrosis factor-alpha and Metalloproteinase 9 mRNA levels were also reduced after the HMUFA diet compared with the HSFA diet (p < 0.05).
   Conclusion: Our results indicate that the long-term consumption of a healthy diet model with HMUFA attenuates the postprandial inflammatory state associated with MetS.
C1 [Cruz-Teno, Cristina; Perez-Martinez, Pablo; Delgado-Lista, Javier; Yubero-Serrano, Elena M.; Garcia-Rios, Antonio; Marin, Carmen; Gomez, Purificacion; Jimenez-Gomez, Yolanda; Camargo, Antonio; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Univ Cordoba, Lipids & Atherosclerosis Unit, Reina Sofia Univ Hosp, IMIBIC, E-14004 Cordoba, Spain.
   [Cruz-Teno, Cristina; Perez-Martinez, Pablo; Delgado-Lista, Javier; Yubero-Serrano, Elena M.; Garcia-Rios, Antonio; Marin, Carmen; Gomez, Purificacion; Jimenez-Gomez, Yolanda; Camargo, Antonio; Malagon, Maria M.; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Cordoba, Spain.
   [Rodriguez-Cantalejo, Fernando] Reina Sofia Univ Hosp, Clin Anal Serv, Cordoba, Spain.
   [Malagon, Maria M.] Univ Cordoba, Dept Cell Biol Physiol & Immunol, Reina Sofia Univ Hosp, IMIBIC, E-14004 Cordoba, Spain.
   [Roche, Helen M.] Univ Coll Dublin, Nutrigenom Res Grp, UCD Conway Inst, Sch Publ Hlth & Populat Sci, Dublin 2, Ireland.
C3 Universidad de Cordoba; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN; Instituto de Salud Carlos III; Hospital Universitario
   Reina Sofia - Cordoba; Universidad de Cordoba; University College Dublin
RP López-Miranda, J (corresponding author), Univ Cordoba, Lipids & Atherosclerosis Unit, Reina Sofia Univ Hosp, IMIBIC, Avda Menendez Pidal S-N, E-14004 Cordoba, Spain.
EM jlopezmir@uco.es
RI Sureda, Antoni/N-9588-2019; Lopez-Miranda, Jose/Y-8306-2019; Marin
   Hinojosa, Carmen/AFO-1294-2022; Yubero-Serrano, Elena/H-4832-2013;
   Delgado-Lista, Javier/KAM-7412-2024; Jimenez, Francisco/AAJ-9559-2021;
   Jimenez-Gomez, Yolanda/Y-3742-2018; Perez Martinez, Pablo/AEL-6176-2022;
   MALAGON, MARIA M/L-5386-2014; Camargo Garcia, Antonio/G-9720-2015
OI Delgado Lista, Francisco Javier/0000-0002-2982-2716; Roche,
   Helen/0000-0002-0628-3318; Yubero-Serrano, Elena M/0000-0002-2733-5359;
   Lopez-Miranda, Jose/0000-0002-8844-0718; Perez-Jimenez,
   Francisco/0000-0001-7499-7681; Jimenez-Gomez,
   Yolanda/0000-0002-1607-2717; Perez Martinez, Pablo/0000-0001-7716-8117;
   MALAGON, MARIA M/0000-0002-2419-2727; Camargo Garcia,
   Antonio/0000-0002-0415-4184; Perez Jimenez,
   Francisco/0000-0001-9808-1280
FU European community (LIPGENE European Integrated Proyect) [505944];
   Consejeria de Salud [07/43, PI-0193/2009]; Consejeria de Innovacion;
   Proyecto de investigacion de excelencia; Junta de Andalucia
   [P06-CTS-01425]; Spanish Ministry of Education and Science
   [AGL2006-01979/ALI, AGL2009-12270]; Spanish Ministry of Health
   [CB06/03/0047]
FX This study was supported in part by research grants from the European
   community (LIPGENE European Integrated Proyect-505944), Consejeria de
   Salud (07/43, PI-0193/2009), Consejeria de Innovacion, Proyecto de
   investigacion de excelencia, Junta de Andalucia (P06-CTS-01425), the
   Spanish Ministry of Education and Science (AGL2006-01979/ALI and
   AGL2009-12270) and the Spanish Ministry of Health (CB06/03/0047 (CIBER
   Fisiopatologia de la Obesidad y Nutricion is an initiative of ISCIII)).
   Fondo Europeo de Desarrollo Regional (FEDER). We thank to M Jose
   Gomez-Luna for technical support.
CR Aljada A, 2004, AM J CLIN NUTR, V79, P682
   Aljada A, 2002, METABOLISM, V51, P487, DOI 10.1053/meta.2002.31339
   Bellido C, 2004, AM J CLIN NUTR, V80, P1487, DOI 10.1093/ajcn/80.6.1487
   Courtois G, 2006, ONCOGENE, V25, P6831, DOI 10.1038/sj.onc.1209939
   de Mello VDF, 2008, METABOLISM, V57, P192, DOI 10.1016/j.metabol.2007.08.024
   Esposito K, 2002, CIRCULATION, V106, P2067, DOI 10.1161/01.CIR.0000034509.14906.AE
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Fulop T, 2006, PATHOL BIOL, V54, P375, DOI 10.1016/j.patbio.2006.07.002
   Futterman LG, 2002, AM J CRIT CARE, V11, P482, DOI 10.4037/ajcc2002.11.5.482
   Galic S, 2010, MOL CELL ENDOCRINOL, V316, P129, DOI 10.1016/j.mce.2009.08.018
   Ghanim H, 2004, CIRCULATION, V110, P1564, DOI 10.1161/01.CIR.0000142055.53122.FA
   Grundy SM, 2004, ARTERIOSCL THROM VAS, V24, pE13, DOI 10.1161/01.ATV.0000111245.75752.C6
   HernandezPresa M, 1997, CIRCULATION, V95, P1532
   HOTAMISLIGIL GS, 1995, J CLIN INVEST, V95, P2409, DOI 10.1172/JCI117936
   Jellema A, 2004, EUR J CLIN INVEST, V34, P766, DOI 10.1111/j.1365-2362.2004.01414.x
   Jimenez-Gomez Yolanda, 2009, Atherosclerosis, V204, pe70, DOI 10.1016/j.atherosclerosis.2008.09.011
   Kolovou GD, 2011, CURR VASC PHARMACOL, V9, P258
   Krishnaswamy G, 1999, J INTERF CYTOK RES, V19, P91, DOI 10.1089/107999099314234
   Kugiyama K, 1998, CIRCULATION, V97, P2519, DOI 10.1161/01.CIR.97.25.2519
   Lee CW, 2007, AM J PHYSIOL-LUNG C, V292, pL799, DOI 10.1152/ajplung.00311.2006
   Lin L, 2005, J IMMUNOL, V175, P951, DOI 10.4049/jimmunol.175.2.951
   Lin L, 2004, IMMUNITY, V21, P203, DOI 10.1016/j.immuni.2004.06.016
   Mantena SK, 2006, FREE RADICAL BIO MED, V40, P1603, DOI 10.1016/j.freeradbiomed.2005.12.032
   Meneses ME, 2011, MOL NUTR FOOD RES, V55, P1759, DOI 10.1002/mnfr.201100200
   Miller GJ, 2002, THROMB HAEMOSTASIS, V87, P477
   Nappo F, 2002, J AM COLL CARDIOL, V39, P1145, DOI 10.1016/S0735-1097(02)01741-2
   O'Rourke RW, 2006, CLIN EXP IMMUNOL, V146, P39, DOI 10.1111/j.1365-2249.2006.03186.x
   Pereira MA, 2002, JAMA-J AM MED ASSOC, V287, P2081, DOI 10.1001/jama.287.16.2081
   Perez-Martinez P, 2007, ATHEROSCLEROSIS, V194, pE141, DOI 10.1016/j.atherosclerosis.2006.11.033
   Phillips C, 2006, CURR OPIN CARDIOL, V21, P185, DOI 10.1097/01.hco.0000221579.25878.11
   Piva R, 2006, ANTIOXID REDOX SIGN, V8, P478, DOI 10.1089/ars.2006.8.478
   Porter MH, 2002, J LAB CLIN MED, V139, P140, DOI 10.1067/mlc.2002.121552
   RIEPPONEN P, 1987, SCAND J CLIN LAB INV, V47, P739
   Roberts CK, 2006, J APPL PHYSIOL, V100, P1657, DOI 10.1152/japplphysiol.01292.2005
   Rodríguez JA, 2007, REV ESP CARDIOL, V60, P959, DOI 10.1157/13109649
   Shaw DI, 2009, BRIT J NUTR, V101, P750, DOI 10.1017/S0007114508039962
   Sonnenberg GE, 2004, OBES RES, V12, P180, DOI 10.1038/oby.2004.24
   Stow JL, 2009, IMMUNOBIOLOGY, V214, P601, DOI 10.1016/j.imbio.2008.11.005
   Sun ZW, 2002, SHOCK, V18, P99, DOI 10.1097/00024382-200208000-00001
   van Oostrom AJHHM, 2004, DRUGS, V64, P19, DOI 10.2165/00003495-200464002-00004
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Weldon SM, 2007, J NUTR BIOCHEM, V18, P250, DOI 10.1016/j.jnutbio.2006.04.003
   Williams DEM, 2000, BRIT J NUTR, V83, P257, DOI 10.1017/S0007114500000337
   Xydakis AM, 2004, J CLIN ENDOCR METAB, V89, P2697, DOI 10.1210/jc.2003-031826
   Zalba G, 2007, ARTERIOSCL THROM VAS, V27, P587, DOI 10.1161/01.ATV.0000256467.25384.c6
   Zhou W, 2009, GASTROENTEROLOGY, V137, P1403, DOI 10.1053/j.gastro.2009.06.049
NR 46
TC 76
Z9 79
U1 0
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD JUN
PY 2012
VL 56
IS 6
BP 854
EP 865
DI 10.1002/mnfr.201200096
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 959OU
UT WOS:000305323100003
PM 22707261
DA 2025-06-11
ER

PT J
AU Ye, L
   Hu, P
   Feng, LP
   Huang, LL
   Wang, Y
   Yan, X
   Xiong, J
   Xia, HL
AF Ye, Lei
   Hu, Pan
   Feng, Li-Ping
   Huang, Li-Lu
   Wang, Yi
   Yan, Xin
   Xiong, Jing
   Xia, Hou-Lin
TI Protective Effects of Ferulic Acid on Metabolic Syndrome: A
   Comprehensive Review
SO MOLECULES
LA English
DT Review
DE ferulic acid; metabolic syndrome; diabetes; hyperlipidemia;
   hypertension; obesity
ID HIGH-FAT-DIET; ENDOTHELIUM-DEPENDENT VASODILATION; COMMERCIAL
   HYPOGLYCEMIC DRUGS; HIGH BLOOD-PRESSURE; OXIDATIVE STRESS; ANTIOXIDANT
   ACTIVITY; INSULIN-RESISTANCE; RAT MODEL; IN-VITRO; SUPPRESSES
   ADIPOGENESIS
AB Metabolic syndrome (MetS) is a complex disease in which protein, fat, carbohydrates and other substances are metabolized in a disorderly way. Ferulic acid (FA) is a phenolic acid found in many vegetables, fruits, cereals and Chinese herbs that has a strong effect on ameliorating MetS. However, no review has summarized the mechanisms of FA in treating MetS. This review collected articles related to the effects of FA on ameliorating the common symptoms of MetS, such as diabetes, hyperlipidemia, hypertension and obesity, from different sources involving Web of Science, PubMed and Google Scholar, etc. This review summarizes the potential mechanisms of FA in improving various metabolic disorders according to the collected articles. FA ameliorates diabetes via the inhibition of the expressions of PEPCK, G6Pase and GP, the upregulation of the expressions of GK and GS, and the activation of the PI3K/Akt/GLUT4 signaling pathway. The decrease of blood pressure is related to the endothelial function of the aortas and RAAS. The improvement of the lipid spectrum is mediated via the suppression of the HMG-Co A reductase, by promoting the ACSL1 expression and by the regulation of the factors associated with lipid metabolism. Furthermore, FA inhibits obesity by upregulating the MEK/ERK pathway, the MAPK pathway and the AMPK signaling pathway and by inhibiting SREBP-1 expression. This review can be helpful for the development of FA as an appreciable agent for MetS treatment.
C1 [Ye, Lei; Feng, Li-Ping; Huang, Li-Lu; Wang, Yi; Xia, Hou-Lin] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China.
   [Hu, Pan; Yan, Xin; Xiong, Jing] Chengdu Inst Chinese Herbal Med, Chengdu 610016, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine
RP Xia, HL (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China.; Hu, P (corresponding author), Chengdu Inst Chinese Herbal Med, Chengdu 610016, Peoples R China.
EM hupan123@126.com; xhl64@163.com
CR Adisakwattana S, 2017, NUTRIENTS, V9, DOI 10.3390/nu9020163
   Adisakwattana S, 2009, J ENZYM INHIB MED CH, V24, P1194, DOI 10.1080/14756360902779326
   Akbari CM, 1999, J VASC SURG, V30, P373, DOI 10.1016/S0741-5214(99)70154-0
   Al-Mutairi A, 2021, NUTR CANCER, V73, P282, DOI 10.1080/01635581.2020.1743869
   Alam MA, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0080-3
   Alam MA, 2013, J CARDIOVASC PHARM, V61, P240, DOI 10.1097/FJC.0b013e31827cb600
   Anand S, 2022, PHARMACEUTICALS-BASE, V15, DOI 10.3390/ph15030302
   Ardiansyah, 2008, J AGR FOOD CHEM, V56, P2825, DOI 10.1021/jf072896y
   Ardiansyah, 2007, BRIT J NUTR, V97, P67, DOI 10.1017/S000711450721013X
   Azay-Milhau J, 2013, J ETHNOPHARMACOL, V150, P755, DOI 10.1016/j.jep.2013.09.046
   Badawy D, 2013, CAN J PHYSIOL PHARM, V91, P101, DOI 10.1139/cjpp-2012-0232
   Baek SE, 2014, ANIM CELLS SYST, V18, P93, DOI 10.1080/19768354.2014.904249
   Bairagi U, 2018, DRUG DEV IND PHARM, V44, P1783, DOI 10.1080/03639045.2018.1496448
   Balasubashini MS, 2003, ACTA DIABETOL, V40, P118, DOI 10.1007/s00592-003-0099-6
   Behrendt D, 2002, AM J CARDIOL, V90, p40L, DOI 10.1016/S0002-9149(02)02963-6
   Ben-Shlomo A, 2016, ENDOCRIN METAB CLIN, V45, pXIII, DOI 10.1016/j.ecl.2016.06.015
   Bhaskaragoud G, 2016, BIOCHEM BIOPH RES CO, V476, P82, DOI 10.1016/j.bbrc.2016.05.053
   Bilen O, 2016, ENDOCRIN METAB CLIN, V45, P129, DOI 10.1016/j.ecl.2015.09.009
   Bocco BM, 2016, BRAZ J MED BIOL RES, V49, DOI 10.1590/1414-431X20155003
   Boz H, 2015, CZECH J FOOD SCI, V33, P1, DOI 10.17221/401/2014-CJFS
   Brownsey RW, 1997, CARDIOVASC RES, V34, P3, DOI 10.1016/S0008-6363(97)00051-5
   Bumrungpert A, 2018, NUTRIENTS, V10, DOI 10.3390/nu10060713
   Calnan DR, 2008, ONCOGENE, V27, P2276, DOI 10.1038/onc.2008.21
   Cao RS, 2010, J LIPID RES, V51, P2234, DOI 10.1194/jlr.M004929
   Chaiittianan R, 2016, J FUNCT FOODS, V23, P497, DOI 10.1016/j.jff.2016.03.010
   Chen SY, 2021, AQUACULTURE, V532, DOI 10.1016/j.aquaculture.2020.735972
   Chen SC, 2017, MOL CELL ENDOCRINOL, V440, P57, DOI 10.1016/j.mce.2016.11.011
   Cheng H, 2022, J PHARM ANAL, V12, P541, DOI 10.1016/j.jpha.2021.10.003
   Cho J, 2020, J NUTR BIOCHEM, V77, DOI 10.1016/j.jnutbio.2019.108327
   Choi R, 2011, EXP MOL MED, V43, P676, DOI 10.3858/emm.2011.43.12.078
   Choi S, 2012, KIDNEY RES CLIN PRAC, V31, P227, DOI 10.1016/j.krcp.2012.09.001
   Chowdhury S, 2016, FOOD CHEM TOXICOL, V97, P187, DOI 10.1016/j.fct.2016.09.011
   Cooke JP, 1997, ANNU REV MED, V48, P489, DOI 10.1146/annurev.med.48.1.489
   Costabile G, 2022, NUTR METAB CARDIOVAS, V32, P715, DOI 10.1016/j.numecd.2021.12.016
   de Melo TS, 2017, BRAZ J MED BIOL RES, V50, DOI [10.1590/1414-431X20165630, 10.1590/1414-431x20165630]
   Dhaliwal J, 2020, LIFE SCI, V255, DOI 10.1016/j.lfs.2020.117856
   Duchnowicz P, 2012, EUR J NUTR, V51, P435, DOI 10.1007/s00394-011-0227-y
   El-Bassossy H, 2016, CHEM-BIOL INTERACT, V254, P191, DOI 10.1016/j.cbi.2016.06.013
   Elhessy HM, 2020, ACTA HISTOCHEM, V122, DOI 10.1016/j.acthis.2020.151633
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   Fuchs FD, 2014, J HUM HYPERTENS, V28, P80, DOI 10.1038/jhh.2013.78
   Fuchs FD, 2020, HYPERTENSION, V75, P285, DOI 10.1161/HYPERTENSIONAHA.119.14240
   Fukuda T, 2015, N-S ARCH PHARMACOL, V388, P1113, DOI 10.1007/s00210-015-1171-9
   Gadde KM, 2018, J AM COLL CARDIOL, V71, P69, DOI 10.1016/j.jacc.2017.11.011
   Gao J, 2022, J FUNCT FOODS, V91, DOI 10.1016/j.jff.2022.105009
   Ghosh S, 2018, FOOD CHEM TOXICOL, V118, P272, DOI 10.1016/j.fct.2018.05.029
   Gogoi B, 2014, BIOCHEM BIOPH RES CO, V452, P382, DOI 10.1016/j.bbrc.2014.08.079
   Gu YY, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.621339
   Guo XX, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071697
   Guo XX, 2017, J FOOD BIOCHEM, V41, DOI 10.1111/jfbc.12419
   Halter B, 2021, COMP BIOCHEM PHYS A, V259, DOI 10.1016/j.cbpa.2021.111015
   Heleno SA, 2015, FOOD CHEM, V173, P501, DOI 10.1016/j.foodchem.2014.10.057
   Hu ED, 1996, SCIENCE, V274, P2100, DOI 10.1126/science.274.5295.2100
   Huang JQ, 2018, FOOD FUNCT, V9, P1779, DOI [10.1039/C7FO01825H, 10.1039/c7fo01825h]
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Huang YK, 2021, FOOD CHEM, V363, DOI 10.1016/j.foodchem.2021.130323
   Ibitoye OB, 2018, ARCH PHYSIOL BIOCHEM, V124, P410, DOI 10.1080/13813455.2017.1415938
   Ilavenil S, 2017, J FUNCT FOODS, V37, P293, DOI 10.1016/j.jff.2017.08.002
   Jain PG, 2016, EXCLI J, V15, DOI 10.17179/excli2016-394
   Salazar-López NJ, 2017, NUTRIENTS, V9, DOI 10.3390/nu9070675
   Jung EH, 2007, J AGR FOOD CHEM, V55, P9800, DOI 10.1021/jf0714463
   Kang BB, 2022, J TRADIT COMPL MED, V12, P195, DOI 10.1016/j.jtcme.2021.08.004
   Kang BB, 2020, PHYTOTHER RES, V34, P808, DOI 10.1002/ptr.6561
   Kim HK, 2003, CLIN CHIM ACTA, V327, P129, DOI 10.1016/S0009-8981(02)00344-3
   Kinyua AW, 2018, EXP MOL MED, V50, DOI 10.1038/emm.2017.253
   Koh EJ, 2016, FASEB J, V30
   Koh EJ, 2017, MOLECULES, V22, DOI 10.3390/molecules22050745
   Kumar A, 2007, LIFE SCI, V80, P1236, DOI 10.1016/j.lfs.2006.12.036
   Kuppusamy P, 2021, MOLECULES, V26, DOI 10.3390/molecules26071984
   Lambruschini C, 2021, MOLECULES, V26, DOI 10.3390/molecules26010089
   Lampiasi N, 2018, IMMUNOBIOLOGY, V223, P349, DOI 10.1016/j.imbio.2017.10.046
   Laurent S, 2017, PHARMACOL RES, V124, P116, DOI 10.1016/j.phrs.2017.07.026
   LEVER AF, 1992, KIDNEY INT, V41, pS51
   Li CC, 2018, BBA-MOL CELL BIOL L, V1863, P1498, DOI 10.1016/j.bbalip.2018.10.002
   Li D, 2021, LIFE SCI, V284, DOI 10.1016/j.lfs.2021.119921
   Li PS, 2020, DRUG DES DEV THER, V14, P977, DOI 10.2147/DDDT.S225705
   Li X, 2022, MOLECULES, V27, DOI 10.3390/molecules27186010
   Little R, 2020, MOL NUTR FOOD RES, V64, DOI 10.1002/mnfr.202000034
   Justo ML, 2016, EUR J NUTR, V55, P2011, DOI 10.1007/s00394-015-1015-x
   Luna-Vital D, 2020, J NUTR BIOCHEM, V79, DOI 10.1016/j.jnutbio.2020.108343
   Luo ZX, 2022, NUTRIENTS, V14, DOI 10.3390/nu14122530
   Ma RY, 2022, BIOMED PHARMACOTHER, V153, DOI 10.1016/j.biopha.2022.113424
   Malloy MJ, 2012, CURR OPIN LIPIDOL, V23, P591, DOI 10.1097/MOL.0b013e328359f162
   Matowane GR, 2022, DIABETIC MED, V39, DOI 10.1111/dme.14905
   Matsuzaka T, 2004, DIABETES, V53, P560, DOI 10.2337/diabetes.53.3.560
   Mirhashemi SM, 2012, AFR J PHARM PHARMACO, V6, P671, DOI 10.5897/AJPP12.033
   Nankar R, 2017, PHYTOMEDICINE, V37, P10, DOI 10.1016/j.phymed.2017.10.015
   Naowaboot J, 2018, ASIAN PAC J TROP BIO, V8, P604, DOI 10.4103/2221-1691.248098
   Naowaboot J, 2016, CLIN EXP PHARMACOL P, V43, P242, DOI 10.1111/1440-1681.12514
   Narasimhan A, 2015, EUR J PHARMACOL, V761, P391, DOI 10.1016/j.ejphar.2015.04.043
   Narasimhan A, 2015, APPL PHYSIOL NUTR ME, V40, P769, DOI 10.1139/apnm-2015-0002
   Nelson RH, 2013, PRIMARY CARE, V40, P195, DOI 10.1016/j.pop.2012.11.003
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Ohnishi M, 2004, BIOFACTORS, V21, P315, DOI 10.1002/biof.552210161
   Park S, 2022, J FUNCT FOODS, V95, DOI 10.1016/j.jff.2022.105180
   Park TJ, 2021, BMB REP, V54, P124, DOI 10.5483/BMBRep.2021.54.2.262
   Pérez-Torres I, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22041786
   Prabhakar PK, 2013, PHYTOMEDICINE, V20, P488, DOI 10.1016/j.phymed.2012.12.004
   Prabhakar PK, 2011, J AGR FOOD CHEM, V59, P9835, DOI 10.1021/jf2015717
   Prabhakar PK, 2009, PHYTOMEDICINE, V16, P1119, DOI 10.1016/j.phymed.2009.05.021
   Prasun P, 2020, BBA-MOL BASIS DIS, V1866, DOI 10.1016/j.bbadis.2020.165838
   Prusty D, 2002, J BIOL CHEM, V277, P46226, DOI 10.1074/jbc.M207776200
   Malarvizhi R, 2021, J FOOD BIOCHEM, V45, DOI 10.1111/jfbc.13595
   Raj PS, 2019, FUND CLIN PHARMACOL, V33, P412, DOI 10.1111/fcp.12452
   Ramar M, 2012, EUR J PHARMACOL, V690, P226, DOI 10.1016/j.ejphar.2012.05.019
   Reis JS, 2008, ARQ BRAS ENDOCRINOL, V52, P1096, DOI 10.1590/S0004-27302008000700005
   Roche A, 2017, CRIT REV FOOD SCI, V57, P1089, DOI 10.1080/10408398.2013.865589
   Roy S, 2013, ENDOCRINE, V44, P369, DOI 10.1007/s12020-012-9868-8
   Salau VF, 2023, FUND CLIN PHARMACOL, V37, P44, DOI 10.1111/fcp.12819
   Salau VF, 2022, J FOOD BIOCHEM, V46, DOI 10.1111/jfbc.13641
   Samson SL, 2014, ENDOCRIN METAB CLIN, V43, P1, DOI 10.1016/j.ecl.2013.09.009
   Sarma S, 2021, DIABETES OBES METAB, V23, P3, DOI 10.1111/dom.14290
   Senaphan K, 2015, NUTRIENTS, V7, P6446, DOI 10.3390/nu7085283
   Seo CR, 2015, J FUNCT FOODS, V12, P208, DOI 10.1016/j.jff.2014.11.022
   SHARMA RD, 1980, ATHEROSCLEROSIS, V37, P463, DOI 10.1016/0021-9150(80)90152-5
   Shewry PR, 2012, FOOD ENERGY SECUR, V1, P47, DOI 10.1002/fes3.2
   Sompong W, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0129495
   Son MJ, 2011, J FOOD SCI, V76, pH7, DOI 10.1111/j.1750-3841.2010.01907.x
   Son MJ, 2010, J CLIN BIOCHEM NUTR, V46, P150, DOI 10.3164/jcbn.09-98
   Song Y, 2014, J FUNCT FOODS, V9, P141, DOI 10.1016/j.jff.2014.04.007
   Srinivasan M, 2007, J CLIN BIOCHEM NUTR, V40, P92, DOI 10.3164/jcbn.40.92
   Steinberg HO, 1996, J CLIN INVEST, V97, P2601, DOI 10.1172/JCI118709
   Sudheer AR, 2005, TOXICOL MECH METHOD, V15, P375, DOI 10.1080/15376520500194783
   Suzuki A, 2002, AM J HYPERTENS, V15, P351, DOI 10.1016/S0895-7061(01)02337-8
   Suzuki A, 2007, AM J HYPERTENS, V20, P508, DOI 10.1016/j.amjhyper.2006.11.008
   te Riet L, 2015, CIRC RES, V116, P960, DOI 10.1161/CIRCRESAHA.116.303587
   Tian BM, 2022, EUR J NUTR, V61, P3767, DOI 10.1007/s00394-022-02927-7
   Totani N, 2012, J OLEO SCI, V61, P331, DOI 10.5650/jos.61.331
   Van Rymenant E, 2017, J NUTR BIOCHEM, V44, P44, DOI 10.1016/j.jnutbio.2017.02.018
   Vinayagam R, 2016, PHYTOTHER RES, V30, P184, DOI 10.1002/ptr.5528
   Wagman AS, 2001, CURR PHARM DESIGN, V7, P417, DOI 10.2174/1381612013397915
   Wang J, 2011, J ETHNOPHARMACOL, V137, P992, DOI 10.1016/j.jep.2011.07.019
   Wang LY, 2015, CHIN J NAT MEDICINES, V13, P401, DOI 10.1016/S1875-5364(15)30032-7
   Wang O, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.957321
   Wang WW, 2019, J AGR FOOD CHEM, V67, P4250, DOI 10.1021/acs.jafc.8b06760
   Wang WW, 2018, FOOD AGR IMMUNOL, V29, P1116, DOI 10.1080/09540105.2018.1516739
   Wang YX, 2020, NUTRIENTS, V12, DOI 10.3390/nu12123811
   Wang ZY, 2021, FOOD CHEM TOXICOL, V149, DOI 10.1016/j.fct.2021.111978
   West IC, 2000, DIABETIC MED, V17, P171, DOI 10.1046/j.1464-5491.2000.00259.x
   Wierzbicki AS, 2021, CURR OPIN CARDIOL, V36, P461, DOI 10.1097/HCO.0000000000000869
   Wu XL, 2021, J BIOCHEM MOL TOXIC, V35, DOI 10.1002/jbt.22664
   Xenoulis PG, 2015, J SMALL ANIM PRACT, V56, P595, DOI 10.1111/jsap.12396
   Yang GW, 2015, INT J MOL SCI, V16, P24011, DOI 10.3390/ijms161024011
   Yeh YH, 2009, J FOOD DRUG ANAL, V17, P123
   Yin YH, 2014, BIOSCI TRENDS, V8, P217, DOI 10.5582/bst.2014.01081
   Yogeeta SK, 2006, BASIC CLIN PHARMACOL, V98, P467, DOI 10.1111/j.1742-7843.2006.pto_335.x
   Zhang X, 2018, FITOTERAPIA, V125, P147, DOI 10.1016/j.fitote.2018.01.005
   Zhang Y, 2021, J MED FOOD, V24, P775, DOI 10.1089/jmf.2020.0147
   Zhao J, 2020, CELL MOL BIOL, V66, P37, DOI 10.14715/cmb/2019.66.1.6
   Zheng KYZ, 2014, PLANTA MED, V80, P159, DOI 10.1055/s-0033-1360314
   Zhu DJ, 2022, PEERJ, V10, DOI 10.7717/peerj.13375
NR 151
TC 30
Z9 30
U1 4
U2 60
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD JAN
PY 2023
VL 28
IS 1
AR 281
DI 10.3390/molecules28010281
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 7P8OE
UT WOS:000908958200001
PM 36615475
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sánchez-Solís, CN
   Hernández-Fragoso, H
   Aburto-Luna, V
   Olivier, CB
   Diaz, A
   Brambila, E
   Treviño, S
AF Neftaly Sanchez-Solis, Cristhian
   Hernandez-Fragoso, Hugo
   Aburto-Luna, Violeta
   Barbier Olivier, Christophe
   Diaz, Alfonso
   Brambila, Eduardo
   Trevino, Samuel
TI Kidney Adaptations Prevent Loss of Trace Elements in Wistar Rats with
   Early Metabolic Syndrome
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Metabolic syndrome; Chronic kidney disease; Hypercaloric diet; Trace
   elements; Micronutrients
ID INSULIN-RESISTANCE; DIABETES-MELLITUS; OXIDATIVE STRESS; PROXIMAL
   TUBULE; NONDIABETIC SUBJECTS; DOUBLE-BLIND; DISEASE; INJURY;
   ADIPONECTIN; ASSOCIATION
AB Metabolic syndrome (MetS) represents a cluster of related metabolic abnormalities, including central obesity, hypertension, dyslipidemia, hyperglycemia, and insulin resistance. These metabolic derangements present significant risk factors for chronic kidney disease that carries to loss of essential micronutrients, which accelerates comorbidity apparition. The work aimed was to evaluate the trace element homeostasis regarding morphological adaptations and renal function in MetS early-onset. Fifty male Wistar rats were divided into two groups: (a) control group and (b) hypercaloric diet group that developed MetS early-onset after 3 months. Classical zoometric parameters do not show changes; however, biochemical modifications were observed such as hyperglycemia, protein glycation, insulin resistance, dyslipidemia, hyperinsulinemia, and hypoadiponectinemia. MetS early-onset group observed renal structural modifications, but no functional changes. The structural modifications observed were minimal glomerular injury, glomerular basement membrane thickening, as well as mesangial and tubular cells that showed growth and proliferation. In serum and kidney (cortex and medulla), the concentrations of Zn, Fe, Cr, Mg, Mn, Cu, Co, and Ni were no differences between the experimental groups, but excretory fractions of these were lower in the hypercaloric diet group. In conclusion, MetS early-onset coexist renal structural modification and a hyperreabsorptive activity of essential trace elements that avoid its loss; thus, the excretory fraction of oligo-elements could be used a biomarker of early renal injury caused by metabolic diseases in the clinical practice.
C1 [Neftaly Sanchez-Solis, Cristhian; Hernandez-Fragoso, Hugo; Aburto-Luna, Violeta; Brambila, Eduardo; Trevino, Samuel] Benemerita Univ Autonoma Puebla, Fac Ciencias Quim, Lab Invest Quim Clin, Puebla, Mexico.
   [Barbier Olivier, Christophe] Inst Politecn Nacl, Dept Toxicol, Ctr Invest & Estudios Avanzados, Mexico City, DF, Mexico.
   [Diaz, Alfonso] Benemerita Univ Autonoma Puebla, Fac Ciencias Quim, Dept Farm, Puebla, Mexico.
   [Trevino, Samuel] Univ Autonoma Puebla, Fac Ciencias Quim, Dept Quim Clin, Lab Invest Quim Clin, 14 Sur FCQ1,Ciudad Univ, Puebla 72560, Mexico.
C3 Benemerita Universidad Autonoma de Puebla; Instituto Politecnico
   Nacional - Mexico; CINVESTAV - Centro de Investigacion y de Estudios
   Avanzados del Instituto Politecnico Nacional; Benemerita Universidad
   Autonoma de Puebla; Benemerita Universidad Autonoma de Puebla
RP Treviño, S (corresponding author), Benemerita Univ Autonoma Puebla, Fac Ciencias Quim, Lab Invest Quim Clin, Puebla, Mexico.; Treviño, S (corresponding author), Univ Autonoma Puebla, Fac Ciencias Quim, Dept Quim Clin, Lab Invest Quim Clin, 14 Sur FCQ1,Ciudad Univ, Puebla 72560, Mexico.
EM samuel_trevino@hotmail.com
RI Barbier, Olivier/AFU-7274-2022
OI Barbier, Olivier Christophe/0000-0002-0378-3675; Diaz,
   Alfonso/0000-0003-4092-6636; Sanchez Solis, Cristhian
   Neftaly/0000-0001-9184-2278; , Hugo/0000-0001-5422-8367; Brambila,
   Eduardo/0000-0003-0377-0943
FU Vicerrectoria de Investigacion y Posgrado [VIEP] [TRMS-NAT19-1, 000536];
   "Sistema Nacional de Investigadores" of Mexico [000536]; CONACyT
   [000536]
FX The Vicerrectoria de Investigacion y Posgrado [VIEP; TRMS-NAT19-1]
   through Ygnacio Martinez Laguna, CONACyT and the "Sistema Nacional de
   Investigadores" of Mexico provided financial support for this research
   project [CNSS, 000536].
CR Aghadavod E, 2020, IRAN J KIDNEY DIS, V14, P31
   Aguilar V, 2007, ANN NUTR METAB, V51, P402, DOI 10.1159/000108108
   Al-Timimi DJ, 2014, J CLIN DIAGN RES, V8, pCC1, DOI [10.7860/JCDR/2014/8112.4349, 10.7860/JCDR/2014/10090.5082]
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Badran M, 2016, J TRACE ELEM MED BIO, V33, P114, DOI 10.1016/j.jtemb.2015.10.006
   Barbagallo Mario, 2003, Molecular Aspects of Medicine, V24, P39, DOI 10.1016/S0098-2997(02)00090-0
   Barbato A, 2004, DIABETOLOGIA, V47, P40, DOI 10.1007/s00125-003-1260-z
   Bossola M, 2014, INT UROL NEPHROL, V46, P809, DOI 10.1007/s11255-014-0689-y
   Cappuccio FP, 1996, J HYPERTENS, V14, P909, DOI 10.1097/00004872-199607000-00015
   Chen J, 2017, CLIN CHIM ACTA, V470, P103, DOI 10.1016/j.cca.2017.05.012
   Chevalier RL, 2016, AM J PHYSIOL-RENAL, V311, pF145, DOI 10.1152/ajprenal.00164.2016
   Choi H, 2012, KIDNEY RES CLIN PRAC, V31, P106, DOI 10.1016/j.krcp.2012.04.317
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Curtis LH, 2007, DIABETES CARE, V30, P2553, DOI 10.2337/dc07-0460
   Dahan I, 2018, J DIABETES RES, V2018, DOI 10.1155/2018/7163652
   Diaz A, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/1358057
   Dominguez JH, 2015, PHYSIOL REP, V3, DOI 10.14814/phy2.12654
   Duarte FO, 2012, EXP PHYSIOL, V97, P882, DOI 10.1113/expphysiol.2011.064121
   El-Khashab SO, 2019, SAUDI J KIDNEY DIS T, V30, P1381, DOI 10.4103/1319-2442.275482
   Sarmiento-Ortega VE, 2018, TOXICS, V6, DOI 10.3390/toxics6030055
   Eshed I, 2001, ENDOCR RES, V27, P91, DOI 10.1081/ERC-100107172
   Farhadnejad H, 2016, NUTRIENTS, V8, DOI 10.3390/nu8040217
   Farriol M, 1997, J ANIM PHYSIOL AN N, V77, P61, DOI 10.1111/j.1439-0396.1997.tb00738.x
   Gilbert RE, 2017, DIABETES, V66, P791, DOI 10.2337/db16-0796
   Gill V, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9120888
   Guerrero-Romero F, 2004, DIABETES METAB, V30, P253, DOI 10.1016/S1262-3636(07)70116-7
   Haap M, 2003, ANN INTERN MED, V139, P869, DOI 10.7326/0003-4819-139-10-200311180-00029
   Hallow KM, 2017, AM J PHYSIOL-RENAL, V312, pF819, DOI 10.1152/ajprenal.00497.2016
   Heiss G, 2014, DIABETES CARE, V37, P2391, DOI 10.2337/dc13-2505
   Higgins SP, 2018, CELL SIGNAL, V43, P1, DOI 10.1016/j.cellsig.2017.11.005
   Hirano T, 2018, J ATHEROSCLER THROMB, V25, P771, DOI 10.5551/jat.RV17023
   Isshiki K, 2008, KIDNEY INT, V74, P1434, DOI 10.1038/ki.2008.403
   Jankowska M, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030282
   Juanola-Falgarona M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076433
   Karganov MY, 2020, BIOL TRACE ELEM RES, V198, P567, DOI 10.1007/s12011-020-02090-2
   Kaur B, 2014, ADV FOOD NUTR RES, V71, P55, DOI 10.1016/B978-0-12-800270-4.00002-X
   Kazi TG, 2008, BIOL TRACE ELEM RES, V122, P1, DOI 10.1007/s12011-007-8062-y
   Khan F, 2015, BIOL TRACE ELEM RES, V168, P321, DOI 10.1007/s12011-015-0379-3
   Kim Y, 2019, INT J MOL SCI, P20
   KORC M, 1983, AM J PHYSIOL, V245, pG628, DOI 10.1152/ajpgi.1983.245.5.G628
   Lee MJ, 2007, AM J PHYSIOL-RENAL, V292, pF617, DOI 10.1152/ajprenal.00278.2006
   Lejk Agnieszka, 2019, Pediatr Endocrinol Diabetes Metab, V25, P81, DOI 10.5114/pedm.2019.85818
   Lerman LO, 2011, REV ESP CARDIOL, V64, P358, DOI 10.1016/j.recesp.2011.01.005
   Liao CC, 2020, DIABET METAB SYND OB, V13, P1, DOI 10.2147/DMSO.S228954
   Lin JW, 2009, DIABETES CARE, V32, P2294, DOI 10.2337/dc09-0694
   Litwin M, 2014, PEDIATR NEPHROL, V29, P203, DOI 10.1007/s00467-013-2500-1
   Liu YF, 2020, FRONT CELL DEV BIOL, V8, DOI 10.3389/fcell.2020.00172
   Lu Q, 2013, EXP PHYSIOL, V98, P934, DOI 10.1113/expphysiol.2012.068361
   Makhlough Atieh, 2015, Nephrourol Mon, V7, pe28576, DOI 10.5812/numonthly.28576
   Mariappan MM, 2014, AM J PHYSIOL-CELL PH, V306, pC202, DOI 10.1152/ajpcell.00144.2013
   Martín-del-Campo F, 2012, PERITON DIALYSIS INT, V32, P183, DOI 10.3747/pdi.2010.00245
   Masson E, 2005, BIOCHEM J, V388, P537, DOI 10.1042/BJ20041506
   Matsumura M, 2000, INTERNAL MED, V39, P55, DOI 10.2169/internalmedicine.39.55
   Mooren FC, 2011, DIABETES OBES METAB, V13, P281, DOI 10.1111/j.1463-1326.2010.01332.x
   Morrisey K, 2001, AM J PATHOL, V159, P1905, DOI 10.1016/S0002-9440(10)63037-4
   Nichols GA, 2011, METAB SYNDR RELAT D, V9, P127, DOI 10.1089/met.2010.0105
   Nishiyama A, 2004, J AM SOC NEPHROL, V15, P306, DOI 10.1097/01.ASN.0000108523.02100.E0
   Nunes S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12040881
   Ohashi Y, 2013, AM J TRANSPLANT, V13, P2342, DOI 10.1111/ajt.12369
   Ouedraogo R, 2006, DIABETES, V55, P1840, DOI 10.2337/db05-1174
   Qiu Y, 2019, ANN NUTR METAB, V75, P168, DOI 10.1159/000504356
   RAIJ L, 1984, KIDNEY INT, V26, P137, DOI 10.1038/ki.1984.147
   Rashidbeygi E, 2019, DIAB MET SYND CLIN R, V13, P830, DOI 10.1016/j.dsx.2018.12.006
   RESNICK LM, 1993, AM J HYPERTENS, V6, P413, DOI 10.1093/ajh/6.5.413
   ROSYID F.N., 2017, International Journal of Research in Medical Sciences, V5, P4206, DOI [10.18203/2320-6012.ijrms20174548, DOI 10.18203/2320-6012.IJRMS20174548]
   Samadi A, 2020, CLIN NUTR, V39, P1849, DOI 10.1016/j.clnu.2019.07.026
   Santamaria-Juarez C, 2022, ARCH PHYSIOL BIOCHEM, V128, P748, DOI 10.1080/13813455.2020.1726403
   Savelieff MG, 2020, CURR OPIN ENDOCRINOL, V27, P115, DOI 10.1097/MED.0000000000000533
   Shen YY, 2008, NEPHROLOGY, V13, P528, DOI 10.1111/j.1440-1797.2008.01018.x
   Siddiqui K, 2014, SCI WORLD J, DOI 10.1155/2014/461591
   Simmons RK, 2010, DIABETOLOGIA, V53, P600, DOI 10.1007/s00125-009-1620-4
   Sobczak AIS, 2019, BIOMETALS, V32, P123, DOI 10.1007/s10534-018-00167-z
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Spoto B, 2016, AM J PHYSIOL-RENAL, V311, pF1087, DOI 10.1152/ajprenal.00340.2016
   Szczuko M, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20071719
   Tang XH, 2001, J NUTR, V131, P1414, DOI 10.1093/jn/131.5.1414
   Thethi T, 2012, CURR HYPERTENS REP, V14, P160, DOI 10.1007/s11906-012-0245-z
   Thomas G, 2011, CLIN J AM SOC NEPHRO, V6, P2364, DOI 10.2215/CJN.02180311
   Thrailkill KM, 2009, ENDOCRINE, V35, P1, DOI 10.1007/s12020-008-9114-6
   Tinkov AA, 2017, BIOL TRACE ELEM RES, V175, P367, DOI 10.1007/s12011-016-0777-1
   Tonelli M, 2009, BMC MED, V7, DOI 10.1186/1741-7015-7-25
   Treviño S, 2017, J CHEM NEUROANAT, V82, P65, DOI 10.1016/j.jchemneu.2017.02.007
   Treviño S, 2015, ARCH BIOCHEM BIOPHYS, V583, P27, DOI 10.1016/j.abb.2015.07.010
   Treviño S, 2015, SYNAPSE, V69, P421, DOI 10.1002/syn.21832
   Treviño S, 2015, J INORG BIOCHEM, V147, P85, DOI 10.1016/j.jinorgbio.2015.04.002
   Vallon V, 2002, J AM SOC NEPHROL, V13, P1865, DOI 10.1097/01.ASN.0000016441.41118.57
   Vallon V, 2020, NAT REV NEPHROL, V16, P317, DOI 10.1038/s41581-020-0256-y
   Vallon V, 2012, ANNU REV PHYSIOL, V74, P351, DOI 10.1146/annurev-physiol-020911-153333
   Vallon V, 2011, AM J PHYSIOL-REG I, V300, pR1009, DOI 10.1152/ajpregu.00809.2010
   Alvarez MV, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17061891
   Waheed F, 2013, MOL BIOL CELL, V24, P1068, DOI 10.1091/mbc.E12-09-0661
   Wang ZW, 2005, DIABETES, V54, P2328, DOI 10.2337/diabetes.54.8.2328
   Westerterp KR, 2006, PHYSIOL BEHAV, V89, P62, DOI 10.1016/j.physbeh.2005.12.014
   Wilson JG, 2003, AM J MED SCI, V325, P332, DOI 10.1097/00000441-200306000-00004
   Xu H, 2017, NEPHROLOGY, V22, P31, DOI 10.1111/nep.13147
   Yamauchi T, 2002, NAT MED, V8, P1288, DOI 10.1038/nm788
   Zhang Y, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/4709715
NR 97
TC 4
Z9 4
U1 1
U2 6
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD MAY
PY 2021
VL 199
IS 5
BP 1941
EP 1953
DI 10.1007/s12011-020-02317-2
EA AUG 2020
PG 13
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA RC0CV
UT WOS:000559276900003
PM 32789645
DA 2025-06-11
ER

PT J
AU Sureda, A
   Bibiloni, MD
   Martorell, M
   Buil-Cosiales, P
   Marti, A
   Pons, A
   Tur, JA
   Martinez-Gonzalez, MA
AF Sureda, Antoni
   del Mar Bibiloni, Maria
   Martorell, Miquel
   Buil-Cosiales, Pilar
   Marti, Amelia
   Pons, Antoni
   Tur, Josep A.
   Angel Martinez-Gonzalez, Miguel
CA PREDIMED Study Investigators
TI Mediterranean diets supplemented with virgin olive oil and nuts enhance
   plasmatic antioxidant capabilities and decrease xanthine oxidase
   activity in people with metabolic syndrome: The PREDIMED study
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Antioxidant enzymes; Nitrosative damage; Oxidative damage; PREDIMED;
   Prooxidant markers
ID SPONTANEOUSLY HYPERTENSIVE-RATS; SUPEROXIDE DISMUTASE ACTIVITY;
   OXIDATIVE STRESS; NITRIC-OXIDE; BLOOD-PRESSURE; FOLLOW-UP;
   CARDIOVASCULAR-DISEASE; LIPOPROTEIN OXIDATION; ADHERENCE; HEALTH
AB Scope: This study assessed plasmatic antioxidant capabilities and xanthine oxidase (XOX) activity in metabolic syndrome patients after 5 years intervention with Mediterranean diet (Me-Diet) supplemented with extra-virgin olive oil or with nuts or with low-fat diet (the PREDIMED [PREvencion con Dieta MEDiterranea] study).
   Methods and results: Seventy-five participants were randomly selected. Daily energy and nutrient intake were assessed with a validated 137-item food frequency questionnaire, and adherence to the MeDiet was assessed using a 14-item questionnaire. Catalase, superoxide dismutase (SOD), myeloperoxidase, XOX activities and protein levels, and protein carbonyl derivatives, nitrotyrosine, nitrite and nitrate levels were determined in overnight fasting venous blood samples. The plasma activity and protein levels of SOD and catalase were significantly higher and XOX activity was lower in MeDiet supplemented with extra-virgin olive oil and MeDiet supplemented with nuts than in the control group. Participants in both MeDiet groups showed higher plasma nitrate levels than in the control group. Adherence to the MeDiet showed a positive correlation with SOD and catalase plasma antioxidant activities.
   Conclusion: A MeDiet enriched with either virgin olive oil or nuts enhances the plasma antioxidant capabilities and decreases XOX activity in patients with the metabolic syndrome but we did not observe changes in myeloperoxidase or markers of oxidative damage.
C1 [Sureda, Antoni; del Mar Bibiloni, Maria; Martorell, Miquel; Pons, Antoni; Tur, Josep A.] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain.
   [Sureda, Antoni; del Mar Bibiloni, Maria; Buil-Cosiales, Pilar; Marti, Amelia; Pons, Antoni; Tur, Josep A.; Angel Martinez-Gonzalez, Miguel] Inst Salud Carlos III, RD 06 0045, Madrid, Spain.
   [Sureda, Antoni; del Mar Bibiloni, Maria; Buil-Cosiales, Pilar; Marti, Amelia; Pons, Antoni; Tur, Josep A.; Angel Martinez-Gonzalez, Miguel] Inst Salud Carlos III, CIBEROBN Fisiopatol Obesidad & Nutr, Madrid, Spain.
   [Martorell, Miquel] Univ Concepcion, Fac Farm, Dept Nutr & Dietet, Concepcion, Chile.
   [Buil-Cosiales, Pilar; Marti, Amelia; Angel Martinez-Gonzalez, Miguel] Univ Navarra IDISNA, Dept Prevent Med & Publ Hlth, Sch Med, Pamplona, Spain.
C3 Universitat de les Illes Balears; Instituto de Salud Carlos III;
   Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica
   en Red; CIBEROBN; Universidad de Concepcion; University of Navarra
RP Tur, JA (corresponding author), Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain.; Tur, JA (corresponding author), Inst Salud Carlos III, RD 06 0045, Madrid, Spain.; Tur, JA (corresponding author), Inst Salud Carlos III, CIBEROBN Fisiopatol Obesidad & Nutr, Madrid, Spain.
EM pep.tur@uib.es
RI Tur, Josep/AAE-5748-2020; Martinez-Gonzalez, Miguel/AAE-7669-2019;
   Sureda, Antoni/N-9588-2019; del Mar Bibiloni, Maria/M-3123-2014; Pons,
   Antoni/L-4844-2014; Martorell, Miquel/H-8490-2014; Marti del Moral,
   Amelia/H-1192-2017
OI Buil-Cosiales, Pilar/0000-0002-8586-577X; Pons,
   Antoni/0000-0003-2447-3868; Bibiloni Esteva, Maria del
   Mar/0000-0001-8926-9206; Martorell, Miquel/0000-0003-3183-7623;
   Martinez-Gonzalez, Miguel A./0000-0002-3917-9808; Marti del Moral,
   Amelia/0000-0001-9832-7981; , Antoni/0000-0001-8656-6838
FU Spanish Ministry of Health and Consumption Affairs [11/01791, 14/00636,
   Red Predimed-RETIC RD06/0045/1004, CIBEROBN CB12/03/30038]; BI Govnt.
   [35/2011]; EU FEDER funds
FX This study was funded by the Spanish Ministry of Health and Consumption
   Affairs (Projects 11/01791, 14/00636, Red Predimed-RETIC RD06/0045/1004,
   and CIBEROBN CB12/03/30038), Grant of support to research groups no.
   35/2011 (BI Govnt.), and EU FEDER funds.
CR Aebi H., 1984, METHOD ENZYMAT AN, P673
   Martinez-Gonzalez MA, 2014, CURR OPIN LIPIDOL, V25, P20, DOI 10.1097/MOL.0000000000000044
   Martínez-González MA, 2012, INT J EPIDEMIOL, V41, P377, DOI 10.1093/ije/dyq250
   Babio N, 2014, CAN MED ASSOC J, V186, pE649, DOI 10.1503/cmaj.140764
   Battelli MG, 2014, ATHEROSCLEROSIS, V237, P562, DOI 10.1016/j.atherosclerosis.2014.10.006
   Bekkouche L, 2014, HORM METAB RES, V46, P274, DOI 10.1055/s-0033-1363657
   Bescós R, 2012, MED SCI SPORT EXER, V44, P2400, DOI 10.1249/MSS.0b013e3182687e5c
   Bescós R, 2012, SPORTS MED, V42, P99, DOI 10.2165/11596860-000000000-00000
   BRAMAN RS, 1989, ANAL CHEM, V61, P2715, DOI 10.1021/ac00199a007
   Capeillère-Blandin C, 1998, BIOCHEM J, V336, P395, DOI 10.1042/bj3360395
   Carnevale R, 2014, ATHEROSCLEROSIS, V235, P649, DOI 10.1016/j.atherosclerosis.2014.05.954
   Carrera-Quintanar L, 2012, SCAND J MED SCI SPOR, V22, P454, DOI 10.1111/j.1600-0838.2010.01244.x
   CASTEGNARO M, 1987, FOOD ADDIT CONTAM A, V4, P37, DOI 10.1080/02652038709373612
   Cohen RA, 2010, J CARDIOVASC PHARM, V55, P308, DOI 10.1097/FJC.0b013e3181d89670
   Corella D, 2009, J NUTR, V139, P128, DOI 10.3945/jn.108.093054
   Dalle-Donne I, 2003, CLIN CHIM ACTA, V329, P23, DOI 10.1016/S0009-8981(03)00003-2
   de Cavanagh EMV, 2010, AM J HYPERTENS, V23, P1318, DOI 10.1038/ajh.2010.167
   Di Massimo C, 2006, LIFE SCI, V78, P1163, DOI 10.1016/j.lfs.2005.06.037
   Estruch R, 2013, NEW ENGL J MED, V368, P1279, DOI 10.1056/NEJMoa1200303
   Estruch R, 2010, P NUTR SOC, V69, P333, DOI 10.1017/S0029665110001539
   Fatehi-Hassanabad Z, 2010, EUR J PHARMACOL, V636, P8, DOI 10.1016/j.ejphar.2010.03.048
   Fernández-Ballarth JD, 2010, BRIT J NUTR, V103, P1808, DOI 10.1017/S0007114509993837
   Fitó M, 2007, ARCH INTERN MED, V167, P1195, DOI 10.1001/archinte.167.11.1195
   Gladwin MT, 2004, FREE RADICAL BIO MED, V36, P707, DOI 10.1016/j.freeradbiomed.2003.11.032
   Gow AJ, 2004, AM J PHYSIOL-LUNG C, V287, pL262, DOI 10.1152/ajplung.00295.2003
   Guxens M, 2009, AM J HYPERTENS, V22, P68, DOI 10.1038/ajh.2008.313
   Hochholzer W, 2010, AM HEART J, V160, P583, DOI 10.1016/j.ahj.2010.06.010
   Hord NG, 2009, AM J CLIN NUTR, V90, P1, DOI 10.3945/ajcn.2008.27131
   Kolomvotsou AI, 2013, EUR J NUTR, V52, P37, DOI 10.1007/s00394-011-0283-3
   Krauss RM, 2000, CIRCULATION, V102, P2284
   Lundberg JO, 2011, CARDIOVASC RES, V89, P525, DOI 10.1093/cvr/cvq325
   Martínez-González MA, 2004, EUR J CLIN NUTR, V58, P1550, DOI 10.1038/sj.ejcn.1602004
   MCCORD JM, 1969, J BIOL CHEM, V244, P6049
   Medina-Remón A, 2013, NUTR METAB CARDIOVAS, V23, P944, DOI 10.1016/j.numecd.2012.07.008
   Medina-Remón A, 2011, NUTR METAB CARDIOVAS, V21, P323, DOI 10.1016/j.numecd.2009.10.019
   Mestre-Alfaro A, 2011, EUR J APPL PHYSIOL, V111, P2281, DOI 10.1007/s00421-011-1862-y
   Ohta M, 2005, HYPERTENS RES, V28, P779, DOI 10.1291/hypres.28.779
   Osler M, 1997, INT J EPIDEMIOL, V26, P155, DOI 10.1093/ije/26.1.155
   Feoli AMP, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/587083
   Park H, 2006, CLIN CHIM ACTA, V374, P129, DOI 10.1016/j.cca.2006.06.004
   Perona JS, 2010, J NUTR BIOCHEM, V21, P892, DOI 10.1016/j.jnutbio.2009.07.005
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   Razquin C, 2009, EUR J CLIN NUTR, V63, P1387, DOI 10.1038/ejcn.2009.106
   Razquin C, 2009, BRIT J NUTR, V102, P672, DOI 10.1017/S0007114509289008
   Rodrigo R, 2008, CLIN SCI, V114, P625, DOI 10.1042/CS20070343
   Romeu M, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-102
   Salas-Salvadó J, 2008, ARCH INTERN MED, V168, P2449, DOI 10.1001/archinte.168.22.2449
   Sánchez-Tainta A, 2008, EUR J CARDIOV PREV R, V15, P589, DOI 10.1097/HJR.0b013e328308ba61
   Sari I, 2010, NUTRITION, V26, P399, DOI 10.1016/j.nut.2009.05.023
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Szasz T, 2010, J CARDIOVASC PHARM, V56, P627, DOI 10.1097/FJC.0b013e3181f80194
   Tauler P, 1999, PFLUG ARCH EUR J PHY, V438, P782, DOI 10.1007/s004240051107
   Mitjavila MT, 2013, CLIN NUTR, V32, P172, DOI 10.1016/j.clnu.2012.08.002
   Trichopoulou A, 2003, NEW ENGL J MED, V348, P2599, DOI 10.1056/NEJMoa025039
   Trichopoulou A, 2014, BMC MED, V12, DOI 10.1186/1741-7015-12-112
   Tsai MH, 2010, J BIOMED SCI, V17, DOI 10.1186/1423-0127-17-67
   Urquiaga I, 2010, ATHEROSCLEROSIS, V211, P694, DOI 10.1016/j.atherosclerosis.2010.04.020
   Vengen IT, 2010, ATHEROSCLEROSIS, V212, P614, DOI 10.1016/j.atherosclerosis.2010.06.008
   Vorbach C, 2003, TRENDS IMMUNOL, V24, P512, DOI 10.1016/S1471-4906(03)00237-0
   Wind S, 2010, HYPERTENSION, V56, P490, DOI 10.1161/HYPERTENSIONAHA.109.149187
   Zazpe I, 2008, J AM DIET ASSOC, V108, P1134, DOI 10.1016/j.jada.2008.04.011
   Zhou LC, 2006, FREE RADICAL BIO MED, V41, P1384, DOI 10.1016/j.freeradbiomed.2006.07.019
   Zicha J, 2001, J HYPERTENS, V19, P247, DOI 10.1097/00004872-200102000-00011
NR 63
TC 51
Z9 52
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD DEC
PY 2016
VL 60
IS 12
BP 2654
EP 2664
DI 10.1002/mnfr.201600450
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA EJ3ZV
UT WOS:000393156600012
PM 27600061
DA 2025-06-11
ER

PT J
AU Vigil, L
   Condés, E
   Varela, M
   Rodriguez, C
   Colas, A
   Vargas, B
   Lopez, M
   Cirugeda, E
AF Vigil, Luis
   Condes, Emilia
   Varela, Manuel
   Rodriguez, Carmen
   Colas, Ana
   Vargas, Borja
   Lopez, Manuel
   Cirugeda, Eva
TI Glucose series complexity in hypertensive patients
SO JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION
LA English
DT Article
DE Detrended fluctuation analysis; diabetes mellitus; metabolic syndrome;
   mean amplitude of glycemic excursions
ID APPROXIMATE ENTROPY; METABOLIC SYNDROME; OXIDATIVE STRESS; GLYCEMIC
   PROFILE; HEART-RATE; DYNAMICS; FLUCTUATIONS; VARIABILITY
AB Nonlinear methods have been applied to the analysis of biological signals. Complexity analysis of glucose time series may be a useful tool for the study of the initial phases of glucoregulatory dysfunction. This observational, cross-sectional study was performed in patients with essential hypertension. Glucose complexity was measured with detrended fluctuation analysis (DFA), and glucose variability was measured by the mean amplitudes of glycemic excursion (MAGE). We included 91 patients with a mean age of 59 10 years. We found significant correlations for the number of metabolic syndrome (MS)-defining criteria with DFA (r = 0.233, P =.026) and MAGE (r = 0.396, P <.0001). DFA differed significantly between patients who complied with MS and those who did not (1.44 vs. 1.39, P =.018). The MAGE (f = 5.3, P =.006), diastolic blood pressures (f = 4.1, P =.018), and homeostasis model assessment indices (f = 4.2, P =.018) differed between the DFA tertiles. Multivariate analysis revealed that the only independent determinants of the DFA values were MAGE (beta coefficient = 0.002, 95% confidence interval: 0.001-0.004, P = .001) and abdominal circumference (beta coefficient = 0.002, 95% confidence interval: 0.000015-0.004, P = .048). In our population, DFA was associated with MS and a number of MS criteria. Complexity analysis seemed to be capable of detecting differences in variables that are arguably related to the risk of the development of type 2 diabetes. (C) 2014 American Society of Hypertension. All rights reserved.
C1 [Vigil, Luis; Varela, Manuel; Rodriguez, Carmen; Colas, Ana; Vargas, Borja; Lopez, Manuel] Univ Hosp Mostoles, Dept Internal Med, Madrid 28935, Spain.
   [Condes, Emilia] Univ Europea Madrid, Madrid, Spain.
   [Cirugeda, Eva] Univ Politecn Valencia, Comp Sci Dept DISCA, Alcoy, Spain.
C3 Hospital Universitario de Mostoles; European University of Madrid;
   Universitat Politecnica de Valencia
RP Vigil, L (corresponding author), Univ Hosp Mostoles, Dept Internal Med, Hypertens Unit, C Rio Jucar S-N, Madrid 28935, Spain.
EM lvigil.hmtl@salud.madrid.org
RI Vargas, Borja/K-4297-2018; Cirugeda, Eva/AAH-2096-2019; Colás,
   Ana/AFP-2489-2022; Lopez Jimenez, Manuel/C-1649-2016; Condes,
   Emilia/E-3582-2016; Vigil, Luis/C-6875-2016; Rodriguez-Castro,
   Carmen/C-5442-2016
OI Lopez Jimenez, Manuel/0000-0002-5205-1630; Vargas,
   Borja/0000-0002-5553-8372; Condes, Emilia/0000-0001-6756-3316; Colas
   Herrera, Ana/0000-0003-2784-4150; Vigil, Luis/0000-0001-7484-2911;
   Cirugeda Roldan, Eva M./0000-0002-0623-3652; Rodriguez-Castro,
   Carmen/0000-0003-4970-9187
FU Fondo de Investigacion Sanitaria, Ministerio de Sanidad y Consumo, Spain
   [11/00811]
FX Grant Support: Supported by Grant 11/00811 of the Fondo de Investigacion
   Sanitaria, Ministerio de Sanidad y Consumo, Spain.
CR Almog Y, 1999, IEEE T BIO-MED ENG, V46, P535, DOI 10.1109/10.759054
   Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
   Bog-Hansen E, 2003, DIABETES OBES METAB, V5, P379, DOI 10.1046/j.1463-1326.2003.00288.x
   Bruhn J, 2000, ANESTHESIOLOGY, V93, P981, DOI 10.1097/00000542-200010000-00018
   Ceriello A, 2008, DIABETES, V57, P1349, DOI 10.2337/db08-0063
   Churruca J, 2008, DIABETES METAB SYNDR, V1, P3
   Engoren M, 1998, CRIT CARE MED, V26, P1817, DOI 10.1097/00003246-199811000-00021
   García-Puig J, 2006, AM J MED, V119, P318, DOI 10.1016/j.amjmed.2005.09.010
   Gautier A, 2010, DIABETES CARE, V33, P1850, DOI 10.2337/dc10-0368
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Lundelin K, 2010, CRIT CARE MED, V38, P849, DOI 10.1097/CCM.0b013e3181ce49cf
   Makikallio TH, 1997, AM J CARDIOL, V80, P779
   Mäkikallio TH, 1999, AM J CARDIOL, V83, P836, DOI 10.1016/S0002-9149(98)01076-5
   Monnier L, 2006, JAMA-J AM MED ASSOC, V295, P1681, DOI 10.1001/jama.295.14.1681
   Muggeo M, 2000, DIABETES CARE, V23, P45, DOI 10.2337/diacare.23.1.45
   Ogata H, 2007, METHOD INFORM MED, V46, P222, DOI 10.1055/s-0038-1625411
   Ogata H, 2006, AM J PHYSIOL-REG I, V291, pR1638, DOI 10.1152/ajpregu.00241.2006
   Ogata H, 2012, METABOLISM, V61, P1041, DOI 10.1016/j.metabol.2011.12.007
   PENG CK, 1995, CHAOS, V5, P82, DOI 10.1063/1.166141
   PINCUS SM, 1991, P NATL ACAD SCI USA, V88, P2297, DOI 10.1073/pnas.88.6.2297
   Richman JS, 2000, AM J PHYSIOL-HEART C, V278, pH2039
   Selvin E, 2010, NEW ENGL J MED, V362, P800, DOI 10.1056/NEJMoa0908359
   Su G, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-19
   Teraguchi I, 2014, CIRC J, V78, P170, DOI 10.1253/circj.CJ-13-0723
   Yamamoto N, 2010, DIABETES TECHNOL THE, V12, P775, DOI 10.1089/dia.2010.0059
NR 25
TC 5
Z9 5
U1 0
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1933-1711
EI 1878-7436
J9 J AM SOC HYPERTENS
JI J. Am. Soc. Hypertens.
PD SEP
PY 2014
VL 8
IS 9
BP 630
EP 636
DI 10.1016/j.jash.2014.05.008
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AQ1PK
UT WOS:000342553100004
PM 25065679
DA 2025-06-11
ER

PT J
AU Mok, CC
AF Mok, Chi Chiu
TI Metabolic syndrome and systemic lupus erythematosus: the connection
SO EXPERT REVIEW OF CLINICAL IMMUNOLOGY
LA English
DT Review
DE Obesity; cardiovascular; lupus; metabolic syndrome; adipokine
ID INCREASED ARTERIAL STIFFNESS; INSULIN-RESISTANCE; CARDIOVASCULAR RISK;
   ASYMMETRIC DIMETHYLARGININE; RHEUMATOID-ARTHRITIS; OXIDATIVE STRESS;
   LEPTIN LEVELS; ORGAN DAMAGE; ALL-CAUSE; ANTIPHOSPHOLIPID SYNDROME
AB Introduction: The metabolic syndrome (MetS) is now recognized as a chronic proinflammatory and prothrombotic state that aggravates insulin resistance, oxidative injury, and cardiovascular risk. MetS is more prevalent in patients with systemic lupus erythematosus (SLE), a prototype of systemic autoimmune disease associated with premature atherosclerosis that cannot be accounted by traditional vascular risk factors alone. Dysregulation of the cytokines and adipokines is a common feature in both SLE and MetS, suggesting a complex relationship among autoimmunity, obesity, inflammation, and atherosclerosis.Areas covered: This review summarizes the prevalence of MetS and its effect on cardiovascular outcome and organ damage in patients with SLE. The pathophysiology of MetS and its relevance to SLE is also briefly discussed.Expert opinion: Imbalance of adipokine production in MetS contributes to inflammation and atherosclerosis. MetS predisposes SLE patients to new cardiovascular events and vascular mortality, as well as the development of chronic kidney disease and diabetes mellitus. However, conflicting results have been reported in the literature regarding the levels of the proinflammatory leptin and anti-inflammatory adiponectin, and their relationship with disease activity in SLE patients. While lifestyle modifications and targeting dyslipidemia, hypertension and diabetes mellitus is essential, there is little information on the efficacy and safety of metformin and hydroxychloroquine in alleviating insulin resistance in SLE or MetS. Further research on adipokines in SLE and the role of anti-obesity medications and probiotics in MetS is necessary.
C1 [Mok, Chi Chiu] Tuen Mun Hosp, Dept Med, Hong Kong, Peoples R China.
C3 Tuen Mun Hospital
RP Mok, CC (corresponding author), Tuen Mun Hosp, Div Rheumatol, Dept Med, Tsing Chung Koon Rd, Hong Kong, Peoples R China.
EM ccmok2005@yahoo.com
OI Mok, CC/0000-0003-3696-1228
CR Abella V, 2014, J IMMUNOL RES, V2014, DOI 10.1155/2014/343746
   García-Villegas EA, 2015, MED CLIN-BARCELONA, V144, P289, DOI 10.1016/j.medcli.2014.06.018
   Al-Herz A, 2003, J RHEUMATOL, V30, P493
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Alessi MC, 2006, ARTERIOSCL THROM VAS, V26, P2200, DOI 10.1161/01.ATV.0000242905.41404.68
   Alexander CM, 2003, DIABETES, V52, P1210, DOI 10.2337/diabetes.52.5.1210
   Balkau B, 1999, DIABETIC MED, V16, P442
   Bao PL, 2015, INT J CLIN EXP MED, V8, P13491
   Bellomio V, 2009, LUPUS, V18, P1019, DOI 10.1177/0961203309105876
   Bertsias GK, 2012, ANN RHEUM DIS, V71, P1771, DOI 10.1136/annrheumdis-2012-201940
   Bloomgarden ZT, 2003, DIABETES CARE, V26, P1297, DOI 10.2337/diacare.26.4.1297
   Borba EF, 1997, LUPUS, V6, P533, DOI 10.1177/096120339700600610
   Bravo PE, 2006, VASC HEALTH RISK MAN, V2, P163, DOI 10.2147/vhrm.2006.2.2.163
   Cameron A, 2010, MATURITAS, V65, P117, DOI 10.1016/j.maturitas.2009.11.026
   Castejon R, 2016, LUPUS, V25, P129, DOI 10.1177/0961203315603138
   Chen HL, 2018, J RHEUMATOL, V45, P83, DOI 10.3899/jrheum.160214
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Chen Q, 2016, INT J CARDIOL, V224, P8, DOI 10.1016/j.ijcard.2016.08.324
   Chougule D, 2018, CYTOKINE, V111, P20, DOI 10.1016/j.cyto.2018.08.002
   Chung CP, 2009, LUPUS, V18, P799, DOI 10.1177/0961203309103582
   Chung CP, 2008, ARTHRITIS RHEUM-US, V58, P2105, DOI 10.1002/art.23600
   Chung CP, 2007, ANN RHEUM DIS, V66, P208, DOI 10.1136/ard.2006.054973
   Conti F, 2016, LUPUS, V25, P719, DOI 10.1177/0961203315627199
   Cozier YC, 2018, SEMIN ARTHRITIS RHEU, VS0049-0172(18)30425-6
   Croca S, 2017, BEST PRACT RES CL RH, V31, P364, DOI 10.1016/j.berh.2017.09.012
   Santos LFDF, 2018, LUPUS, V27, P380, DOI 10.1177/0961203317723716
   Medeiros MMD, 2016, RHEUMATOL INT, V36, P117, DOI 10.1007/s00296-015-3316-z
   De Sanctis JB, 2009, AUTOIMMUNITY, V42, P272, DOI 10.1080/08916930902828031
   Demir S, 2018, LUPUS, V27, P1509, DOI 10.1177/0961203318782424
   Demir S, 2016, LUPUS, V25, P177, DOI 10.1177/0961203315603140
   Dimitroulas T, 2012, INT J MOL SCI, V13, P12315, DOI 10.3390/ijms131012315
   Dini AA, 2017, JCR-J CLIN RHEUMATOL, V23, P361, DOI 10.1097/RHU.0000000000000580
   El Magadmi M, 2006, J RHEUMATOL, V33, P50
   Fanouriakis A, 2019, ANN RHEUM DIS, V2019
   Fatemi A, 2018, CLIN RHEUMATOL, V37, P1521, DOI 10.1007/s10067-017-3970-5
   Floris A, 2018, MEDIAT INFLAMM, V2018, DOI 10.1155/2018/3424136
   Frühbeck G, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-06997-0
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   AGheita T, 2013, Z RHEUMATOL, V72, P172, DOI 10.1007/s00393-012-1058-9
   Grandl G, 2018, SEMIN IMMUNOPATHOL, V40, P215, DOI 10.1007/s00281-017-0666-5
   Grundy SM, 2019, J AM COLL CARDIOL, V73, P3168, DOI [10.1016/j.jacc.2018.11.002, 10.1161/CIR.0000000000000625, 10.1016/j.jacc.2018.11.003]
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Hallajzadeh J, 2018, LUPUS, V1
   Heng D, 2006, ATHEROSCLEROSIS, V186, P367, DOI 10.1016/j.atherosclerosis.2005.07.020
   Hess PL, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.117.006103
   Huang Q, 2015, CLIN RHEUMATOL, V34, P1713, DOI 10.1007/s10067-015-2955-5
   Hui WS, 2010, EUR J EPIDEMIOL, V25, P375, DOI 10.1007/s10654-010-9459-z
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Ju SY, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000008491
   Katsiki N, 2017, CURR OPIN LIPIDOL, V28, P347, DOI 10.1097/MOL.0000000000000431
   Katz P, 2012, ARTHRIT CARE RES, V64, P502, DOI 10.1002/acr.21587
   Katz P, 2011, ARTHRIT CARE RES, V63, P261, DOI 10.1002/acr.20343
   Katz-Agranov N, 2017, IMMUNOL RES, V65, P432, DOI 10.1007/s12026-017-8906-2
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kern PA, 2001, AM J PHYSIOL-ENDOC M, V280, pE745
   Kiani AN, 2007, J RHEUMATOL, V34, P1502
   Ladeiras-Lopes R, 2015, EXPERT OPIN THER TAR, V19, P869, DOI 10.1517/14728222.2015.1025051
   Larsen JR, 2018, EXPERT REV CLIN PHAR, V11, P397, DOI 10.1080/17512433.2018.1429910
   Lee JW, 2018, QUAL LIFE RES, V27, P105, DOI 10.1007/s11136-017-1689-z
   Li HM, 2016, IMMUNOL RES, V64, P820, DOI 10.1007/s12026-016-8808-8
   Li HM, 2015, ARCH MED RES, V46, P551, DOI 10.1016/j.arcmed.2015.09.005
   Li W, 2008, CEREBROVASC DIS, V25, P539, DOI 10.1159/000131672
   Lozovoy MAB, 2013, SCAND J RHEUMATOL, V42, P303, DOI 10.3109/03009742.2012.754942
   Lumeng CN, 2011, J CLIN INVEST, V121, P2111, DOI 10.1172/JCI57132
   Ma X, 2013, EUR J CLIN NUTR, V67, P518, DOI 10.1038/ejcn.2013.24
   Magder LS, 2012, AM J EPIDEMIOL, V176, P708, DOI 10.1093/aje/kws130
   Rodrigues CEM, 2012, ARTHRIT CARE RES, V64, P1576, DOI 10.1002/acr.21701
   Margiotta DPE, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0187645
   Sabio JM, 2011, J RHEUMATOL, V38, P1026, DOI 10.3899/jrheum.101132
   Sabio JM, 2009, J RHEUMATOL, V36, P2204, DOI 10.3899/jrheum.081253
   Marso SP, 2016, NEW ENGL J MED, V375, P311, DOI 10.1056/NEJMoa1603827
   Matsuzawa Y, 2004, ARTERIOSCL THROM VAS, V24, P29, DOI 10.1161/01.ATV.0000099786.99623.EF
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   McKellar GE, 2009, NAT REV CARDIOL, V6, P410, DOI 10.1038/nrcardio.2009.57
   McMahon M, 2011, ANN RHEUM DIS, V70, P1619, DOI 10.1136/ard.2010.142737
   Medina G, 2018, PHARMACOL RES, V133, P277, DOI 10.1016/j.phrs.2018.01.009
   Medina G, 2011, AUTOIMMUN REV, V10, P214, DOI 10.1016/j.autrev.2010.10.004
   Miyake CNH, 2018, ARTHRIT CARE RES, V70, P114, DOI 10.1002/acr.23237
   Mobini M, 2018, INT J RHEUM DIS, V21, P1023, DOI 10.1111/1756-185X.13276
   Mok CC, 2018, HONG KONG MED J, V24, P501, DOI 10.12809/hkmj187319
   Mok CC, 2018, CLIN EXP RHEUMATOL, V36, P389
   Mok CC, 2010, SCAND J RHEUMATOL, V39, P42, DOI 10.3109/03009740903046668
   Mok CC, 2006, SCAND J RHEUMATOL, V35, P85, DOI 10.1080/03009740600601526
   Mok CC, 2008, BONE, V43, P327, DOI 10.1016/j.bone.2008.04.003
   Mok CC, 2019, EXPERT OPIN INV DRUG, V28, P85, DOI 10.1080/13543784.2019.1551358
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Muniz LF, 2015, ARTHRIT CARE RES, V67, P1255, DOI 10.1002/acr.22593
   Negrón AM, 2008, LUPUS, V17, P348, DOI 10.1177/0961203307086645
   Novo S, 2012, ATHEROSCLEROSIS, V223, P468, DOI 10.1016/j.atherosclerosis.2012.05.018
   Oeser A, 2005, ARTHRITIS RHEUM-US, V52, P3651, DOI 10.1002/art.21400
   Okopien B, 2018, EXPERT REV CLIN PHAR, V11, P1099, DOI 10.1080/17512433.2018.1537780
   Parker B, 2013, LUPUS, V22, P1259, DOI 10.1177/0961203313502570
   Parker B, 2011, LUPUS, V20, P1459, DOI 10.1177/0961203311416695
   Parker B, 2015, ANN RHEUM DIS, V74, P1530, DOI 10.1136/annrheumdis-2013-203933
   Patterson SL, 2019, ARTHRIT CARE RES, V71, P126, DOI 10.1002/acr.23576
   Perna M, 2010, ARTHRITIS RHEUM-US, V62, P1718, DOI 10.1002/art.27392
   Petri M, 2000, LUPUS, V9, P170, DOI 10.1191/096120300678828226
   Pons-Estel GJ, 2017, J AUTOIMMUN, V76, P10, DOI 10.1016/j.jaut.2016.10.004
   Prasad G V Ramesh, 2014, World J Nephrol, V3, P210, DOI 10.5527/wjn.v3.i4.210
   Ramirez LA, 2018, AM J HYPERTENS, V31, P1247, DOI 10.1093/ajh/hpy148
   Rempenault C, 2018, ANN RHEUM DIS, V77, P98, DOI 10.1136/annrheumdis-2017-211836
   Rodrigues CEM, 2012, CLIN EXP RHEUMATOL, V30, P871
   Ryan MJ, 2006, HYPERTENSION, V48, P988, DOI 10.1161/01.HYP.0000243612.02929.df
   Ryo M, 2004, CIRC J, V68, P975, DOI 10.1253/circj.68.975
   Sabio JM, 2008, LUPUS, V17, P849, DOI 10.1177/0961203308093554
   Sabio JM, 2019, CLIN EXP RHEUMATOL, V37, P286
   Sabio JM, 2015, LUPUS, V24, P155, DOI 10.1177/0961203314551811
   Sánchez-Pérez H, 2017, CLIN EXP RHEUMATOL, V35, P885
   Shaharir SS, 2015, CLIN RHEUMATOL, V34, P93, DOI 10.1007/s10067-014-2802-0
   Sieruo M, 2012, METABOLISM, V61, P680, DOI 10.1016/j.metabol.2011.10.003
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Srikanthan K, 2016, INT J MED SCI, V13, P25, DOI 10.7150/ijms.13800
   Sun C, 2017, INT J RHEUM DIS, V20, P917, DOI 10.1111/1756-185X.13153
   Szabó MZ, 2017, IMMUNOL RES, V65, P543, DOI 10.1007/s12026-016-8892-9
   Tarr T, 2017, CLIN RHEUMATOL, V36, P327, DOI 10.1007/s10067-016-3492-6
   Tedeschi SK, 2017, SEMIN ARTHRITIS RHEU, V47, P376, DOI 10.1016/j.semarthrit.2017.05.011
   Thomas GN, 2007, CLIN ENDOCRINOL, V66, P666, DOI 10.1111/j.1365-2265.2007.02798.x
   Thomas G, 2011, CLIN J AM SOC NEPHRO, V6, P2364, DOI 10.2215/CJN.02180311
   Toller-Kawahisa JE, 2015, FREE RADICAL BIO MED, V86, P362, DOI 10.1016/j.freeradbiomed.2015.06.005
   Torres S, 2019, EUR J NUTR, V58, P27, DOI 10.1007/s00394-018-1790-2
   Tselios K, 2016, SEMIN ARTHRITIS RHEU, V45, P604, DOI 10.1016/j.semarthrit.2015.10.010
   Tyrrell PN, 2007, J RHEUMATOL, V34, P2112
   Vadacca M, 2009, J RHEUMATOL, V36, P295, DOI 10.3899/jrheum.080503
   Valero-Gonzalez S, 2014, SCAND J RHEUMATOL, V43, P54, DOI 10.3109/03009742.2013.803150
   van Herpt TTW, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-016-0387-4
   Van Raemdonck K, 2018, AUTOIMMUN REV, V17, P821, DOI 10.1016/j.autrev.2018.02.007
   Varjabedian L, 2018, AM J CARDIOVASC DRUG, V18, P181, DOI 10.1007/s40256-018-0266-3
   Versini M, 2017, EUR J CLIN INVEST, V47, P422, DOI 10.1111/eci.12757
   de Oliveira GLV, 2017, IMMUNOLOGY, V152, P1, DOI 10.1111/imm.12765
   Wang LM, 2017, LUPUS, V26, P403, DOI 10.1177/0961203316668040
   Wang X, 2017, LUPUS, V26, P1401, DOI 10.1177/0961203317703497
   Wislowska M, 2008, RHEUMATOL INT, V28, P467, DOI 10.1007/s00296-008-0526-7
   Wolf VL, 2019, CURR HYPERTENS REP, V21, DOI 10.1007/s11906-019-0914-2
   Wong ND, 2012, JACC-CARDIOVASC IMAG, V5, P358, DOI 10.1016/j.jcmg.2011.12.015
   Yamaoka K, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-138
   Yen YF, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000000956
   Zhang MF, 2014, AM J MED SCI, V348, P486, DOI 10.1097/MAJ.0000000000000343
   Zhu QZ, 2018, NAT REV NEPHROL, V14, P105, DOI 10.1038/nrneph.2017.157
   Zinman B, 2015, NEW ENGL J MED, V373, P2117, DOI 10.1056/NEJMoa1504720
NR 142
TC 45
Z9 46
U1 1
U2 24
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1744-666X
EI 1744-8409
J9 EXPERT REV CLIN IMMU
JI Expert Rev. Clin. Immunol.
PD JUL 3
PY 2019
VL 15
IS 7
BP 765
EP 775
DI 10.1080/1744666X.2019.1620601
PG 11
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA IG3CH
UT WOS:000473677600008
PM 31094570
DA 2025-06-11
ER

PT J
AU Park, SB
   Kang, JY
   Kim, JM
   Park, SK
   Yoo, SK
   Lee, U
   Kim, DO
   Heo, HJ
AF Park, Su Bin
   Kang, Jin Yong
   Kim, Jong Min
   Park, Seon Kyeong
   Yoo, Seul Ki
   Lee, Uk
   Kim, Dae-Ok
   Heo, Ho Jin
TI Effect of Aruncus dioicus var. kamtschaticus Extract on
   Neurodegeneration Improvement: Ameliorating Role in Cognitive Disorder
   Caused by High-Fat Diet Induced Obesity
SO NUTRIENTS
LA English
DT Article
DE neurodegeneration; metabolic syndrome; insulin resistance; high-fat
   diet; Aruncus dioicus var; kamtschaticus
ID INSULIN-RESISTANCE; TNF-ALPHA; DYSFUNCTION; ACTIVATION; INFLAMMATION;
   SENSITIVITY; DISEASE; BRAIN
AB This study was performed to estimate the possibility of using an ethyl acetate fraction from Aruncus dioicus var. kamtschaticus (EFAD) on metabolic syndrome that is induced by a high-fat diet (HFD). It was demonstrated that EFAD suppresses lipid accumulation and improves insulin resistance (IR) caused by Tumor necrosis factor alpha (TNF-alpha) in in-vitro experiments using the 3T3-L1 cell. In in-vivo tests, C57BL/6 mice were fed EFAD at 20 and 40 mg/kg body weight (BW) for four weeks after the mice were fed HFD for 15 weeks to induce obesity. EFAD significantly suppressed the elevation of BW and improved impaired glucose tolerance in obese mice. Additionally, this study showed that EFAD has an ameliorating effect on obesity-induced cognitive disorder with behavioral tests. The effect of EFAD on peripheral-IR improvement was confirmed by serum analysis and western blotting in peripheral tissues. Additionally, EFAD showed an ameliorating effect on HFD-induced oxidative stress, impaired cholinergic system and mitochondrial dysfunction, which are interrelated symptoms of neurodegeneration, such as Alzheimer's disease and central nervous system (CNS)-IR in brain tissue. Furthermore, we confirmed that EFAD improves CNS-IR by confirming the IR-related factors in brain tissue. Consequently, this study suggests the possibility of using EFAD for the prevention of neurodegeneration by improving metabolic syndrome that is caused by HFD.
C1 [Park, Su Bin; Kang, Jin Yong; Kim, Jong Min; Park, Seon Kyeong; Yoo, Seul Ki; Heo, Ho Jin] Gyeongsang Natl Univ, Div Appl Life Sci BK21 Plus, Inst Agr & Life Sci, Jinju 52828, South Korea.
   [Lee, Uk] Natl Inst Forest Sci, Div Special Forest Prod, Suwon 16631, South Korea.
   [Kim, Dae-Ok] Kyung Hee Univ, Dept Food Sci & Biotechnol, Yongin 17104, South Korea.
C3 Gyeongsang National University; Korea Forest Research Institute (KFRI);
   National Institute of Forest Science (NIFOS), Republic of South Korea;
   Kyung Hee University
RP Heo, HJ (corresponding author), Gyeongsang Natl Univ, Div Appl Life Sci BK21 Plus, Inst Agr & Life Sci, Jinju 52828, South Korea.
EM tbsk5670@naver.com; kangjy2132@naver.com; myrock201@naver.com;
   tjsrud2015@naver.com; ysyk9412@naver.com; rich26@korea.kr;
   dokim05@khu.ac.kr; hjher@gnu.ac.kr
RI Kim, Jinsoo/G-6348-2012; Park, Su-Bin/IVH-9442-2023; Kim,
   Dae-Ok/AAK-7252-2020
OI Kim, Dae-Ok/0000-0001-9262-1354; Kim, Jong Min/0000-0001-7926-4778; heo,
   ho jin/0000-0002-3560-2007
FU Korea Forest Service (Korea Forestry Promotion Institute)
   [2017028A00-1819-BA01]
FX This research was funded by Korea Forest Service (Korea Forestry
   Promotion Institute), grant number Project No. 2017028A00-1819-BA01.
CR Ahmadi-Abhari S, 2017, BMJ-BRIT MED J, V358, DOI 10.1136/bmj.j2856
   Amato A, 2017, NUTRIENTS, V9, DOI 10.3390/nu9050492
   Biessels GJ, 2004, EUR J PHARMACOL, V490, P1, DOI 10.1016/j.ejphar.2004.02.057
   Cawthorn WP, 2008, FEBS LETT, V582, P117, DOI 10.1016/j.febslet.2007.11.051
   Dalby-Brown L, 2005, J AGR FOOD CHEM, V53, P9413, DOI 10.1021/jf0502395
   Dragicevic N, 2010, J ALZHEIMERS DIS, V20, pS535, DOI 10.3233/JAD-2010-100342
   Fisher-Wellman KH, 2012, TRENDS ENDOCRIN MET, V23, P142, DOI 10.1016/j.tem.2011.12.008
   Ha JS, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/876484
   Hajer GR, 2008, EUR HEART J, V29, P2959, DOI 10.1093/eurheartj/ehn387
   Hegazy AM, 2016, HUM EXP TOXICOL, V35, P251, DOI 10.1177/0960327115583361
   Heo HJ, 2004, DEMENT GERIATR COGN, V17, P151, DOI 10.1159/000076349
   HISSIN PJ, 1976, ANAL BIOCHEM, V74, P214, DOI 10.1016/0003-2697(76)90326-2
   Kandimalla R, 2017, BBA-MOL BASIS DIS, V1863, P1078, DOI 10.1016/j.bbadis.2016.08.018
   Kim JM, 2016, BEHAV BRAIN RES, V312, P39, DOI 10.1016/j.bbr.2016.06.013
   Kim J, 2014, ACTA HISTOCHEM, V116, P1490, DOI 10.1016/j.acthis.2014.09.003
   Kim JI, 2018, FOOD SCI BIOTECHNOL, V27, P1467, DOI 10.1007/s10068-018-0390-5
   Lee H, 2016, FITOTERAPIA, V112, P90, DOI 10.1016/j.fitote.2016.05.006
   Leonard S, 2017, EUR J PHARMACOL, V800, P1, DOI 10.1016/j.ejphar.2017.01.007
   MORRIS R, 1984, J NEUROSCI METH, V11, P47, DOI 10.1016/0165-0270(84)90007-4
   Neth BJ, 2017, FRONT AGING NEUROSCI, V9, DOI 10.3389/fnagi.2017.00345
   Nieto-Vazquez Iria, 2008, Archives of Physiology and Biochemistry, V114, P183, DOI 10.1080/13813450802181047 
   Nuzzo D, 2018, NUTRIENTS, V10, DOI 10.3390/nu10091130
   Nuzzo D, 2015, CURR ALZHEIMER RES, V12, P723, DOI 10.2174/1567205012666150710115506
   Park SB, 2018, J FOOD BIOCHEM, V42, DOI 10.1111/jfbc.12667
   PARKSUBIN, 2017, [Korean Journal of Food Science and Technology, 한국식품과학회지], V49, P668, DOI 10.9721/KJFST.2017.49.6.668
   Petrov D, 2015, BBA-MOL BASIS DIS, V1852, P1687, DOI 10.1016/j.bbadis.2015.05.004
   Popkin BM, 2015, CURR DIABETES REP, V15, DOI 10.1007/s11892-015-0631-4
   Rains TM, 2011, J NUTR BIOCHEM, V22, P1, DOI 10.1016/j.jnutbio.2010.06.006
   Schwaiger S., 2009, PLANTA MED, V75, pPA18, DOI [10.1055/s-0029-1234343, DOI 10.1055/S-0029-1234343]
   Son SM, 2015, MOL NEURODEGENER, V10, DOI 10.1186/s13024-015-0054-3
   Sulaiman C, 2014, AVICENNA J PHYTOMEDI, V4, P89
   Tilg H, 2008, CLIN SCI, V114, P275, DOI 10.1042/CS20070196
   Vazquez-Prieto MA, 2012, ARCH BIOCHEM BIOPHYS, V527, P113, DOI 10.1016/j.abb.2012.02.019
   Zhang Qin, 2014, [Korean Journal of Plant Reources., 한국자원식물학회지], V27, P714, DOI 10.7732/kjpr.2014.27.6.714
NR 34
TC 10
Z9 10
U1 1
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2019
VL 11
IS 6
AR 1319
DI 10.3390/nu11061319
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA II1AJ
UT WOS:000474936700125
PM 31212845
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Ueba, T
   Nomura, S
   Nishikawa, T
   Kajiwara, M
   Yamashita, K
AF Ueba, Tetsuya
   Nomura, Shosaku
   Nishikawa, Tomofumi
   Kajiwara, Motohiro
   Yamashita, Kohsuke
TI Circulating oxidized LDL, measured with FOH1a/DLH3 antibody, is
   associated with metabolic syndrome and the coronary heart disease risk
   score in healthy Japanese
SO ATHEROSCLEROSIS
LA English
DT Article
DE Atherosclerosis; oxLDL; Metabolic syndrome; Coronary heart disease risk
   score
ID LOW-DENSITY-LIPOPROTEIN; C-REACTIVE PROTEIN; MIDDLE-AGED MEN; OXIDATIVE
   STRESS; INDEPENDENT PREDICTOR; MARKER
AB Background and purpose: The objective of this study was to clarify the relationship between circulating oxidized LDL (oxLDL) and metabolic syndrome (MS) and the coronary heart disease (CHD) risk score.
   Methods: We conducted a cross-sectional study of healthy volunteers who had no signs, symptoms or history of cardiovascular or cerebrovascular disease and took no medications. We studied 382 Japanese volunteers, 190 men and 192 women (median age 41 and 38 years, respectively). We used an ELISA kit and a monoclonal oxLDL antibody, FOH1a/DLH3, to measure circulating oxLDL.
   Results: The odds ratio (OR) for elevated oxLDL in individuals with MS compared to those without MS, adjusted for age and sex, was 1.94 (range 1.00-3.78). In individuals with a predicted Framingham 10-year risk for CHD>5% (corresponding with the highest quartile), compared to those with a predicted 10-year risk <5%, the OR, adjusted for age, sex, smoking, and LDL cholesterol, was 2.51 (1.17-5.36). The age-, sex-, smoking- and LDL cholesterol-adjusted OR for a 10-year CHD risk score > 5% was 1.03 (1.01-1.04) for LDL cholesterol and 11.7 (4.69-29.0) for smoking.
   Conclusions: Elevated oxLDL is associated with the presence of MS and the CHID risk score in healthy people. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
C1 [Ueba, Tetsuya; Nishikawa, Tomofumi; Kajiwara, Motohiro; Yamashita, Kohsuke] Kishiwada City Hosp, Dept Neurosurg, Kishiwada, Osaka 5968501, Japan.
   [Nomura, Shosaku] Kishiwada City Hosp, Dept Hematol, Kishiwada, Osaka 5968501, Japan.
RP Ueba, T (corresponding author), Kishiwada City Hosp, Dept Neurosurg, 1000 Gakuharachou, Kishiwada, Osaka 5968501, Japan.
EM tueba@kuhp.kyoto-u.ac.jp
RI Ueba, Tetsuya/AFL-6434-2022
CR BERLINER JA, 1990, J CLIN INVEST, V85, P1260, DOI 10.1172/JCI114562
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Devaraj S, 2004, ENDOCRIN METAB CLIN, V33, P431, DOI 10.1016/j.ecl.2004.03.008
   Ehara S, 2002, J DIABETES COMPLICAT, V16, P60, DOI 10.1016/S1056-8727(01)00210-0
   ESTERBAUER H, 1989, FREE RADICAL RES COM, V6, P67, DOI 10.3109/10715768909073429
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Holvoet P, 1998, CIRCULATION, V98, P1487, DOI 10.1161/01.CIR.98.15.1487
   Holvoet P, 2000, ARTERIOSCL THROM VAS, V20, P698, DOI 10.1161/01.ATV.20.3.698
   Holvoet P, 2004, DIABETES, V53, P1068, DOI 10.2337/diabetes.53.4.1068
   Holvoet P, 2003, ARTERIOSCL THROM VAS, V23, P1444, DOI 10.1161/01.ATV.0000080379.05071.22
   Holvoet P, 2001, ARTERIOSCL THROM VAS, V21, P844, DOI 10.1161/01.ATV.21.5.844
   Ishikawa S, 2007, CIRC J, V71, P26, DOI 10.1253/circj.71.26
   Itabe H, 2007, J ATHEROSCLER THROMB, V14, P1, DOI 10.5551/jat.14.1
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Kohno H, 2000, CLIN BIOCHEM, V33, P243, DOI 10.1016/S0009-9120(00)00065-5
   Lapointe A, 2007, ATHEROSCLEROSIS, V191, P362, DOI 10.1016/j.atherosclerosis.2006.03.036
   Meisinger C, 2005, CIRCULATION, V112, P651, DOI 10.1161/CIRCULATIONAHA.104.529297
   Mertens A, 2001, FASEB J, V15, P2073, DOI 10.1096/fj.01-0273rev
   Satoh A, 2005, DIABETES CARE, V28, P2514, DOI 10.2337/diacare.28.10.2514
   Shimada K, 2004, ATHEROSCLEROSIS, V174, P343, DOI 10.1016/j.atherosclerosis.2004.01.029
   Sigurdardottir V, 2002, J INTERN MED, V252, P440, DOI 10.1046/j.1365-2796.2002.01054.x
   Sjogren P, 2005, ARTERIOSCL THROM VAS, V25, P2580, DOI 10.1161/01.ATV.0000190675.08857.3d
   Tanigawa H, 2006, ATHEROSCLEROSIS, V188, P245, DOI 10.1016/j.atherosclerosis.2005.10.046
   Visser M, 1999, JAMA-J AM MED ASSOC, V282, P2131, DOI 10.1001/jama.282.22.2131
   Weinbrenner T, 2003, ATHEROSCLEROSIS, V168, P99, DOI 10.1016/S0021-9150(03)00053-4
   Wiberg B, 2006, STROKE, V37, P2898, DOI 10.1161/01.STR.0000249056.24657.8b
   Wilson PWF, 1998, CIRCULATION, V97, P1837, DOI 10.1161/01.CIR.97.18.1837
   Wu TY, 2006, J AM COLL CARDIOL, V48, P973, DOI 10.1016/j.jacc.2006.03.057
NR 30
TC 17
Z9 17
U1 0
U2 1
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD MAR
PY 2009
VL 203
IS 1
BP 243
EP 248
DI 10.1016/j.atherosclerosis.2008.05.048
PG 6
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 423QL
UT WOS:000264510700037
PM 18635189
DA 2025-06-11
ER

PT J
AU Rickard, IJ
   Lummaa, V
AF Rickard, Ian J.
   Lummaa, Virpi
TI The predictive adaptive response and metabolic syndrome: challenges for
   the hypothesis
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID CORONARY-HEART-DISEASE; LIFE-HISTORY; PRENATAL EXPOSURE; IN-UTERO;
   GROWTH; EVOLUTION; FETAL; MAINTENANCE; CHILDHOOD; MORTALITY
AB In humans and other mammals, maternal undernutrition or stress during gestation results in small offspring with permanently altered metabolism and tissue composition. It has been suggested that such responses might exist because in utero conditions provide a reliable 'prediction' of the environmental conditions that foetuses will eventually be exposed to during adulthood. Thus, some developmental responses to the early environment might improve an individual's evolutionary success in a similar future environment.
C1 Univ Sheffield, Dept Anim & Plant Sci, Sheffield S10 2TN, S Yorkshire, England.
C3 University of Sheffield
RP Rickard, IJ (corresponding author), Univ Sheffield, Dept Anim & Plant Sci, Sheffield S10 2TN, S Yorkshire, England.
EM i.rickard@sheffield.ac.uk
RI Lummaa, Virpi/AHB-0181-2022
OI Rickard, Ian/0000-0003-0762-1689
CR Altimiras J, 2005, CIRCULATION, V111, pE166, DOI 10.1161/01.CIR.0000159348.91164.6F
   [Anonymous], 1992, EVOLUTION LIFE HIST
   [Anonymous], DEV PLASTICITY EVOLU
   ARMELAGOS GJ, 1991, POPUL ENVIRON, V13, P9, DOI 10.1007/BF01256568
   Bateson P, 2004, NATURE, V430, P419, DOI 10.1038/nature02725
   Bateson P, 2001, INT J EPIDEMIOL, V30, P928, DOI 10.1093/ije/30.5.928
   Bertram CE, 2001, BRIT MED BULL, V60, P103, DOI 10.1093/bmb/60.1.103
   Clutton-Brock T.H., 2004, Soay sheep: dynamics and selection in an island population
   Clutton-Brock TH., 1982, Red deer: behavior and ecology of two sexes
   Early JohnD., 1990, POPULATION DYNAMICS
   Foley R.A., 1987, ANOTHER UNIQUE SPECI
   Forsén T, 1999, BRIT MED J, V319, P1403, DOI 10.1136/bmj.319.7222.1403
   Forsén T, 2000, ANN INTERN MED, V133, P176, DOI 10.7326/0003-4819-133-3-200008010-00008
   Gluckman PD, 2006, EUR J ENDOCRINOL, V155, pS47, DOI 10.1530/eje.1.02233
   Gluckman PD, 2006, MOL CELL ENDOCRINOL, V254, P26, DOI 10.1016/j.mce.2006.04.005
   Gluckman PD, 2006, TRENDS ENDOCRIN MET, V17, P7, DOI 10.1016/j.tem.2005.11.006
   Gluckman PD, 2005, TRENDS ECOL EVOL, V20, P527, DOI 10.1016/j.tree.2005.08.001
   Gluckman PD, 2005, P ROY SOC B-BIOL SCI, V272, P671, DOI 10.1098/rspb.2004.3001
   Gluckman Peter., 2005, The Fetal Matrix: Evolution, Development and Disease
   Hales CN, 2001, BRIT MED BULL, V60, P5, DOI 10.1093/bmb/60.1.5
   Hawkes K, 1998, P NATL ACAD SCI USA, V95, P1336, DOI 10.1073/pnas.95.3.1336
   HAZEL W N, 1990, Proceedings of the Royal Society of London Series B Biological Sciences, V242, P181, DOI 10.1098/rspb.1990.0122
   Hill K., 1996, ACHE LIFE HIST
   Howell N., 1979, DEMOGRAPHY DOBE KUNG, Vfirst New York
   Jasienska G, 2006, P NATL ACAD SCI USA, V103, P12759, DOI 10.1073/pnas.0605488103
   Jones JH, 2005, AM J HUM BIOL, V17, P22, DOI 10.1002/ajhb.20099
   Khan I, 2004, CIRCULATION, V110, P1097, DOI 10.1161/01.CIR.0000139843.05436.A0
   Kuzawa CW, 1998, YEARB PHYS ANTHROPOL, V41, P177
   Lahdenperä M, 2004, NATURE, V428, P178, DOI 10.1038/nature02367
   Lerchl A, 1998, INT J BIOMETEOROL, V42, P84, DOI 10.1007/s004840050089
   Mericq V, 2005, DIABETOLOGIA, V48, P2609, DOI 10.1007/s00125-005-0036-z
   Mittelman SD, 2002, DIABETES, V51, P755, DOI 10.2337/diabetes.51.3.755
   MORAN NA, 1992, AM NAT, V139, P971, DOI 10.1086/285369
   Mueller U, 2001, BEHAV ECOL SOCIOBIOL, V50, P302, DOI 10.1007/s002650100370
   Nishida T, 2003, AM J PRIMATOL, V59, P99, DOI 10.1002/ajp.10068
   Painter RC, 2005, REPROD TOXICOL, V20, P345, DOI 10.1016/j.reprotox.2005.04.005
   Phillips DIW, 2001, BRIT MED J, V322, P771, DOI 10.1136/bmj.322.7289.771
   Prentice AM, 2005, P NUTR SOC, V64, P153, DOI 10.1079/PNS2005421
   Ravelli ACJ, 1998, LANCET, V351, P173, DOI 10.1016/S0140-6736(97)07244-9
   Rayco-Solon P, 2004, TROP MED INT HEALTH, V9, P1151, DOI 10.1111/j.1365-3156.2004.01325.x
   Reser JE, 2006, MED HYPOTHESES, V67, P474, DOI 10.1016/j.mehy.2006.03.019
   Sear R, 2004, RES ECON ANTHROPOL, V23, P203, DOI 10.1016/S0190-1281(04)23008-6
   Stanner SA, 1997, BMJ-BRIT MED J, V315, P1342, DOI 10.1136/bmj.315.7119.1342
   Tavecchia G, 2005, J ANIM ECOL, V74, P201, DOI 10.1111/j.1365-2656.2005.00916.x
   WALKER PL, 1988, AM J PHYS ANTHROPOL, V76, P183, DOI 10.1002/ajpa.1330760206
   Walker R, 2006, AM J HUM BIOL, V18, P295, DOI 10.1002/ajhb.20510
   Wells JCK, 2006, TRENDS ECOL EVOL, V21, P424, DOI 10.1016/j.tree.2006.05.006
   Worthman CM, 2005, AM J HUM BIOL, V17, P95, DOI 10.1002/ajhb.20096
NR 48
TC 70
Z9 83
U1 0
U2 28
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD APR
PY 2007
VL 18
IS 3
BP 94
EP 99
DI 10.1016/j.tem.2007.02.004
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 159AT
UT WOS:000245838500004
PM 17320410
DA 2025-06-11
ER

PT J
AU Matsubara, T
   Naruse, K
   Arakawa, T
   Nakao, M
   Yokoi, K
   Oguri, M
   Marui, N
   Amano, T
   Ichimiya, S
   Ohashi, T
   Imai, K
   Sakai, S
   Sugiyama, S
   Ishii, H
   Murohara, T
AF Matsubara, Tatsuaki
   Naruse, Keiko
   Arakawa, Takemi
   Nakao, Masahide
   Yokoi, Kiyoshi
   Oguri, Mitsutoshi
   Marui, Nobuyuki
   Amano, Tetsuya
   Ichimiya, Satoshi
   Ohashi, Taiki
   Imai, Kenji
   Sakai, Shinichi
   Sugiyama, Satoru
   Ishii, Hideki
   Murohara, Toyoaki
TI Impact of pitavastatin on high-sensitivity C-reactive protein and
   adiponectin in hypercholesterolemic patients with the metabolic
   syndrome: The PREMIUM Study
SO JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Metabolic syndrome; Pitavastatin; Inflammation; Adiponectin;
   High-density lipoprotein cholesterol
ID HIGH-DENSITY-LIPOPROTEIN; CORONARY-ARTERY-DISEASE; JAPANESE PATIENTS;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; DIABETES-MELLITUS; OXIDATIVE
   STRESS; EVENTS; MEN; ATHEROSCLEROSIS
AB Background: Inflammatory reactions and oxidative stress, which are important in progression of atherosclerosis, are reported to be increased in individuals with metabolic syndrome (MetS). On the other hand, adiponectin levels are lowered. Since effects of pitavastatin on these parameters have not been reported in hypercholesterolemic patients with MetS, the present study was conducted.
   Purpose: To evaluate the effects of pitavastatin on inflammatory reaction, oxidative stress, and plasma adiponectin levels in hypercholesterolemic MetS patients in a multicenter trial.
   Methods: This open-label, single group study was performed at 7 hospitals in Japan. Pitavastatin (2 mg/day) was administered to 103 consecutive patients with hypercholesterolemia, subdivided into MetS and non-MetS for 12 weeks. Blood samples were collected after overnight fasting at the start of treatment (baseline) and after 12 weeks.
   Results: In the patients with MetS (n = 69), mean values of plasma high-sensitivity C-reactive protein (hs-CRP) were significantly higher and mean values of plasma high-molecular-weight (HMW)-adiponectin significantly lower than in their counterparts without MetS (n = 34). The baseline HMW-adiponectin and high-density lipoprotein cholesterol (HDL-C) values significantly correlated only in the MetS patients (r = 0.318: p = 0.01). In an effectiveness analysis including 94 patients (62 with MetS, 32 without MetS), the level of hs-CRP was significantly decreased in patients with MetS during the drug treatment, whereas HMW-adiponectin did not change. When patients with MetS were divided into two subgroups according to the percent changes in HDL-C, significantly greater increase in HMW-adiponectin by pitavastatin treatment was observed in the HDL-C >= 10% increase subgroup than in the HDL-C < 10% increase subgroup (p = 0.009).
   Conclusion: Twelve weeks administration of pitavastatin, in addition to the antihyperlipidemic effects, may be beneficial as an anti-atherosclerotic therapy in hypercholesterolemic patients with MetS, taking changes in hs-CRP and HMW-adiponectin into consideration. ClinicalTrials.gov identifier: NCT00444717. (c) 2012 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
C1 [Matsubara, Tatsuaki] Aichi Gakuin Univ, Sch Dent, Dept Internal Med, Chikusa Ku, Nagoya, Aichi, Japan.
   [Arakawa, Takemi; Nakao, Masahide] Rinko Hosp, Dept Internal Med, Nagoya, Aichi, Japan.
   [Yokoi, Kiyoshi; Oguri, Mitsutoshi] Gifu Prefectural Govt Tajimi Hosp, Dept Cardiol, Tajimi, Japan.
   [Marui, Nobuyuki; Amano, Tetsuya] Chubu Rosai Hosp, Dept Cardiol, Nagoya, Aichi, Japan.
   [Ichimiya, Satoshi; Ohashi, Taiki] Yokkaichi Municipal Hosp, Dept Cardiol, Yokaichi, Japan.
   [Imai, Kenji] Imai Naika Clin, Nagoya, Aichi, Japan.
   [Sakai, Shinichi] Kainan Hosp, Yatomi, Japan.
   [Sugiyama, Satoru] Inst Appl Biochem, Mitake, Tokyo 50501, Japan.
   [Ishii, Hideki; Murohara, Toyoaki] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi 4648601, Japan.
C3 Aichi Gakuin University; Nagoya University
RP Matsubara, T (corresponding author), Aichi Gakuin Univ, Sch Dent, Dept Internal Med, Chikusa Ku, 2-11 Suemori Dori, Nagoya, Aichi, Japan.
EM matt@dpc.aichi-gakuin.ac.jp
RI Naruse, Keiko/H-3325-2012; Murohara, Toyoaki/M-4958-2014; Ishii,
   Hideki/M-4871-2014
OI Ishii, Hideki/0000-0003-4348-0123
CR Ahluwalia N, 2006, ATHEROSCLEROSIS, V186, P345, DOI 10.1016/j.atherosclerosis.2005.07.021
   Arita Y, 1999, BIOCHEM BIOPH RES CO, V257, P79, DOI 10.1006/bbrc.1999.0255
   Baigent C, 2005, LANCET, V366, P1267, DOI 10.1016/S0140-6736(05)67394-1
   Butler J, 2006, J AM COLL CARDIOL, V47, P1595, DOI 10.1016/j.jacc.2005.12.046
   Cnop M, 2003, DIABETOLOGIA, V46, P459, DOI 10.1007/s00125-003-1074-z
   Simao ANC, 2008, NUTRITION, V24, P675, DOI 10.1016/j.nut.2008.03.021
   Davignon J, 2004, CIRCULATION, V109, P39, DOI 10.1161/01.CIR.0000131517.20177.5a
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   GORDON DJ, 1989, NEW ENGL J MED, V321, P1311
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hara K, 2006, DIABETES CARE, V29, P1123, DOI 10.2337/dc05-2540
   Hara K, 2006, DIABETES CARE, V29, P1357, DOI 10.2337/dc05-1801
   Hayashi T, 2007, EXPERT OPIN PHARMACO, V8, P2315, DOI 10.1517/14656566.8.14.2315
   Imai K, 2001, JPN CIRC J, V65, P495, DOI 10.1253/jcj.65.495
   Inami N, 2007, PATHOPHYSIOL HAEMO T, V36, P1, DOI 10.1159/000112633
   Koshiyama H, 2008, J ATHEROSCLER THROMB, V15, P345, DOI 10.5551/jat.E581
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Li SS, 2009, JAMA-J AM MED ASSOC, V302, P179, DOI 10.1001/jama.2009.976
   Matsushita K, 2006, ARTERIOSCL THROM VAS, V26, P871, DOI 10.1161/01.ATV.0000208363.85388.8f
   Miura S, 2010, J CARDIOL, V55, P287, DOI 10.1016/j.jjcc.2010.02.003
   Morikawa Shigeru, 2002, J Atheroscler Thromb, V9, P178
   Murphy AJ, 2009, CURR MED CHEM, V16, P667, DOI 10.2174/092986709787458425
   Nakamura T, 2008, J CARDIOVASC PHARM, V51, P365, DOI 10.1097/FJC.0b013e318165dcad
   Nomura S, 2008, THROMB RES, V122, P39, DOI 10.1016/j.thromres.2007.08.013
   Pajvani UB, 2003, J BIOL CHEM, V278, P9073, DOI 10.1074/jbc.M207198200
   Ridker PM, 2008, NEW ENGL J MED, V359, P2195, DOI 10.1056/NEJMoa0807646
   Ridker PM, 2001, NEW ENGL J MED, V344, P1959, DOI 10.1056/NEJM200106283442601
   Sakamoto K, 2006, CLIN THER, V28, P1012, DOI 10.1016/j.clinthera.2006.07.001
   Sasaki J, 2008, CLIN THER, V30, P1089, DOI 10.1016/j.clinthera.2008.05.017
   Schulze MB, 2005, DIABETES, V54, P534, DOI 10.2337/diabetes.54.2.534
   Seino Y, 2010, J DIABETES INVEST, V1, P212, DOI 10.1111/j.2040-1124.2010.00074.x
   Shibata R, 2009, CIRC J, V73, P608, DOI 10.1253/circj.CJ-09-0057
   Tailor A, 2000, Curr Hypertens Rep, V2, P78, DOI 10.1007/s11906-000-0063-6
   Teramoto T, 2007, J ATHEROSCLER THROMB, V14, P45, DOI 10.5551/jat.14.45
   Tsubakio-Yamamoto K, 2008, BIOCHEM BIOPH RES CO, V375, P390, DOI 10.1016/j.bbrc.2008.08.009
   Tsunoda R, 2011, J CARDIOL, V58, P208, DOI 10.1016/j.jjcc.2011.07.002
   Uemura Y, 2012, J CARDIOL, V59, P50, DOI 10.1016/j.jjcc.2011.09.001
   Waters DD, 2010, J CARDIOL, V55, P155, DOI 10.1016/j.jjcc.2009.12.003
   Weyer C, 2001, J CLIN ENDOCR METAB, V86, P1930, DOI 10.1210/jc.86.5.1930
   Yamakawa Tadashi, 2008, J Atheroscler Thromb, V15, P269
   Yoshikane Hideki, 2007, J Cardiol, V50, P175
   Zoccali C, 2002, J AM SOC NEPHROL, V13, P134, DOI 10.1681/ASN.V131134
NR 42
TC 21
Z9 22
U1 0
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0914-5087
J9 J CARDIOL
JI J. Cardiol.
PD NOV-DEC
PY 2012
VL 60
IS 5-6
BP 389
EP 394
DI 10.1016/j.jjcc.2012.07.012
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 056HY
UT WOS:000312480200010
PM 22884685
DA 2025-06-11
ER

PT J
AU Ha, MS
   Lee, JH
   Jeong, WM
   Kim, HR
   Son, WH
AF Ha, Min-Seong
   Lee, Jae-Hoon
   Jeong, Woo-Min
   Kim, Hyun Ryun
   Son, Woo Hyeon
TI The Combined Intervention of Aqua Exercise and Burdock Extract
   Synergistically Improved Arterial Stiffness: A Randomized, Double-Blind,
   Controlled Trial
SO METABOLITES
LA English
DT Article
DE aqua exercise; burdock extract; metabolic syndrome; cardiovascular
   disease; vascular endothelial function
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY;
   OXIDATIVE STRESS; PROSTAGLANDIN-X; SMOOTH-MUSCLE; NITRIC-OXIDE
AB Metabolic syndrome (MS), characterized by the presence of risk factors for various metabolic disorders, including impaired glucose tolerance, dyslipidemia, hypertension, and insulin resistance, has a high incidence in the Asian population. Among the various approaches used for improving MS, the combination of exercise and nutrition is of increasing importance. In this randomized controlled trial, we evaluated the effects of combined aqua exercise and burdock extract intake on blood pressure, insulin resistance, arterial stiffness, and vascular regulation factors in older women with MS. A total of 42 participants were randomly assigned into one of four groups (control, exercise, burdock, and exercise + burdock) and underwent a 16-week double-blinded intervention. Blood pressure, insulin resistance, arterial stiffness, and vascular regulation factors were evaluated before and after the intervention. The 16-week intervention of aqua exercise decreased the levels of insulin, glucose, homeostasis model assessment of insulin resistance, and thromboxane A2, but increased the levels of the quantitative insulin sensitivity check index and prostaglandin I2. The combined burdock extract intake and aqua exercise intervention had an additional effect, improving the augmentation index, augmentation index at 75 beats per min, and pulse wave velocity. In conclusion, aqua exercise could improve insulin resistance and vascular regulation factors in older women with MS. Furthermore, combined treatment with burdock extract intake could improve arterial stiffness via a synergistic effect.
C1 [Ha, Min-Seong] Dongguk Univ Seoul, Coll Arts, Dept Sports Culture, 30 Pildong Ro 1 Gil, Seoul 04620, South Korea.
   [Lee, Jae-Hoon] Univ Seoul, Dept Sports Sci, 163 Seoulsiripdae Ro, Seoul 02504, South Korea.
   [Jeong, Woo-Min] Wellcare Korea Co Ltd, 26 Wadong Ro, Ansan 15265, South Korea.
   [Kim, Hyun Ryun] Woosuk Univ, Dept Phys Educ, 443 Samnye Ro, Samnye Eup 55338, Wanju Gun, South Korea.
   [Son, Woo Hyeon] Dong A Univ, Inst Convergence Biohlth, 26 Daesingongwon Ro, Busan 49201, South Korea.
C3 Dongguk University; University of Seoul; Woosuk University; Dong A
   University
RP Ha, MS (corresponding author), Dongguk Univ Seoul, Coll Arts, Dept Sports Culture, 30 Pildong Ro 1 Gil, Seoul 04620, South Korea.; Son, WH (corresponding author), Dong A Univ, Inst Convergence Biohlth, 26 Daesingongwon Ro, Busan 49201, South Korea.
EM haminseong@dgu.ac.kr; physical365@gmail.com
RI 손, 우현/JNE-3360-2023
OI Ha, Min-Seong/0000-0003-4852-2038
FU Ministry of Education of the Republic of Korea; National Research
   Foundation of Korea [NRF-2019S1A5B5A07106826]
FX This research was supported by the Ministry of Education of the Republic
   of Korea and the National Research Foundation of Korea
   (NRF-2019S1A5B5A07106826).
CR Balkau B, 2008, DIABETES, V57, P2613, DOI 10.2337/db07-1605
   Barbosa TM, 2007, J STRENGTH COND RES, V21, P1255
   BLACK HR, 1994, HYPERTENSION, V23, P275
   BORG G, 1970, Scandinavian Journal of Rehabilitation Medicine, V2, P92
   Brook RD, 2001, AM J CARDIOL, V88, P1264, DOI 10.1016/S0002-9149(01)02088-4
   BUNTING S, 1976, PROSTAG OTH LIPID M, V12, P897, DOI 10.1016/0090-6980(76)90125-8
   Cao JianFeng Cao JianFeng, 2012, African Journal of Biotechnology, V11, P9079
   Carr MC, 2003, J CLIN ENDOCR METAB, V88, P2404, DOI 10.1210/jc.2003-030242
   Chen FA, 2004, FOOD CHEM, V86, P479, DOI 10.1016/j.foodchem.2003.09.020
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cunha RM, 2012, HIGH BLOOD PRESS CAR, V19, P223, DOI 10.1007/BF03297634
   Donley DA, 2014, J APPL PHYSIOL, V116, P1396, DOI 10.1152/japplphysiol.00151.2014
   Erhart S, 1999, ACTA HAEMATOL-BASEL, V101, P140, DOI 10.1159/000040940
   Foright RM, 2018, PHYSIOL BEHAV, V188, P86, DOI 10.1016/j.physbeh.2018.01.025
   Fournier SB, 2014, EXP PHYSIOL, V99, P149, DOI 10.1113/expphysiol.2013.075796
   FURCHGOTT RF, 1980, NATURE, V288, P373, DOI 10.1038/288373a0
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Golbidi S, 2012, OXID MED CELL LONGEV, V2012, DOI 10.1155/2012/349710
   Ha MS, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-84301-x
   Ha MS, 2019, J CLIN BIOCHEM NUTR, V64, P73, DOI 10.3164/jcbn.18-60
   Ha MS, 2018, EXP GERONTOL, V101, P63, DOI 10.1016/j.exger.2017.11.005
   Hansen Ane H, 2011, Hypertension, V58, P943, DOI 10.1161/HYPERTENSIONAHA.111.176529
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   KELLY R, 1989, CIRCULATION, V80, P1652, DOI 10.1161/01.CIR.80.6.1652
   Kim BY, 2021, J OBES METAB SYNDR, V30, P81, DOI 10.7570/jomes21022
   Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213
   Kim JH, 2021, HEALTHCARE-BASEL, V9, DOI 10.3390/healthcare9040409
   Kim YJ, 2010, ACTA CARDIOL, V65, P315, DOI 10.2143/AC.65.3.2050348
   Kitahara CM, 2014, CANCER EPIDEM BIOMAR, V23, P2840, DOI 10.1158/1055-9965.EPI-14-0699-T
   Laurent S, 2001, HYPERTENSION, V37, P1236, DOI 10.1161/01.HYP.37.5.1236
   Laurent S, 2006, EUR HEART J, V27, P2588, DOI 10.1093/eurheartj/ehl254
   Lee J, 2020, NUTR RES, V77, P85, DOI 10.1016/j.nutres.2020.03.003
   Lee YJ, 2012, BMC COMPLEM ALTERN M, V12, DOI 10.1186/1472-6882-12-116
   Lupattelli G, 2000, AM HEART J, V140, P521, DOI 10.1067/mhj.2000.108508
   Malaisse W J, 1994, Diabetes Res, V25, P25
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Gamez-Mendez AM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0138609
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McLaughlin T, 2003, ANN INTERN MED, V139, P802, DOI 10.7326/0003-4819-139-10-200311180-00007
   MCVEIGH GE, 1992, DIABETOLOGIA, V35, P771
   MONCADA S, 1977, LANCET, V1, P18
   Morino K, 2006, DIABETES, V55, pS9, DOI 10.2337/db06-S002
   MYKKANEN L, 1993, DIABETOLOGIA, V36, P553, DOI 10.1007/BF02743273
   Nakahata N, 2008, PHARMACOL THERAPEUT, V118, P18, DOI 10.1016/j.pharmthera.2008.01.001
   NICOSIA S, 1984, ADV CYCLIC NUCL PROT, V17, P593
   Padilla Jaume, 2007, Cardiovasc Ultrasound, V5, P45, DOI 10.1186/1476-7120-5-45
   Pahakis MY, 2007, BIOCHEM BIOPH RES CO, V355, P228, DOI 10.1016/j.bbrc.2007.01.137
   Rezaeimanesh D., 2019, J ADV PHARM ED RES, V9, P121
   Riddell DR, 1999, VITAM HORM, V57, P25
   Safar ME, 2006, J AM COLL CARDIOL, V47, P72, DOI 10.1016/j.jacc.2005.08.052
   Sanz C, 2010, DIABETES METAB, V36, P346, DOI 10.1016/j.diabet.2010.06.001
   Scuteri A, 2010, EUR HEART J, V31, P602, DOI 10.1093/eurheartj/ehp491
   Seong Ha Min, 2017, [Journal of the Korean Applied Science and Technology, 한국응용과학기술학회지], V34, P899
   김미선, 2014, 한국식품저장유통학회지, V21, P727
   Stachowiak G, 2015, MENOPAUSE REV, V14, P59, DOI 10.5114/pm.2015.50000
   Stocker R, 2004, PHYSIOL REV, V84, P1381, DOI 10.1152/physrev.00047.2003
   Sypniewska Grazyna, 2007, EJIFCC, V18, P39
   Tillin T, 2005, DIABETOLOGIA, V48, P649, DOI 10.1007/s00125-005-1689-3
   Van Bortel LM, 2002, AM J HYPERTENS, V15, P445, DOI 10.1016/S0895-7061(01)02326-3
   Vanhoutte PM, 2009, ACTA PHYSIOL, V196, P193, DOI 10.1111/j.1748-1716.2009.01964.x
   Vega GL, 2002, OBES RES, V10, p27S, DOI 10.1038/oby.2002.186
   Vlachopoulos C, 2015, ATHEROSCLEROSIS, V241, P507, DOI 10.1016/j.atherosclerosis.2015.05.007
   Wang BS, 2007, FOOD CHEM, V101, P729, DOI 10.1016/j.foodchem.2006.01.051
   Wang PH, 1996, J BIOL CHEM, V271, P29223, DOI 10.1074/jbc.271.46.29223
   WASSERTHEIL S, 1970, BIOMETRICS, V26, P588, DOI 10.2307/2529115
NR 66
TC 3
Z9 3
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD OCT
PY 2022
VL 12
IS 10
AR 970
DI 10.3390/metabo12100970
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 5P5KQ
UT WOS:000873189900001
PM 36295873
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Domingo, P
   Mateo, MG
   Villarroya, J
   Cereijo, R
   Torres, F
   Domingo, JC
   Campderros, L
   Gallego-Escuredo, JM
   Gutierrez, MD
   Mur, I
   Corbacho, N
   Vidal, F
   Villarroya, F
   Giralt, M
AF Domingo, Pere
   Mateo, Maria Gracia
   Villarroya, Joan
   Cereijo, Ruben
   Torres, Ferran
   Domingo, Joan C.
   Campderros, Laura
   Gallego-Escuredo, Jose M.
   Gutierrez, Maria del Mar
   Mur, Isabel
   Corbacho, Noemi
   Vidal, Francesc
   Villarroya, Francesc
   Giralt, Marta
TI Increased Circulating Levels of Growth Differentiation Factor 15 in
   Association with Metabolic Disorders in People Living with HIV Receiving
   Combined Antiretroviral Therapy
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE GDF15; cardiovascular risk; Framingham; D; A; insulin resistance;
   metabolic syndrome; HALS
ID CARDIOVASCULAR-DISEASE; RISK PREDICTION; LIPODYSTROPHY; DYSFUNCTION;
   INFECTION; ABACAVIR; PROFILE; EVENTS; STRESS; MARKER
AB Objective: People living with HIV (PLWH) have an increased cardiovascular risk (CVR) owing to dyslipidemia, insulin resistance, metabolic syndrome, and HIV/combination antiretroviral therapy (cART)-associated lipodystrophy (HALS). Atherosclerosis and inflammation are related to growth differentiation factor-15 (GDF15). The relationship between metabolic disturbances, HALS, and CVR with GDF15 in PLWH is not known. Research design and methods: Circulating GDF15 levels in 152 PLWH (with HALS = 60, without HALS = 43, cART-naive = 49) and 34 healthy controls were assessed in a cross-sectional study. Correlations with lipids, glucose homeostasis, fat distribution, and CVR were explored. Results: PLWH had increased circulating GDF15 levels relative to controls. The increase was the largest in cART-treated PLWH. Age, homeostatic model assessment of insulin resistance 1 (HOMA1-IR), HALS, dyslipidemia, C-reactive protein, and CVR estimated with the Framingham score correlated with GDF15 levels. The GDF15-Framingham correlation was lost after age adjustment. No correlation was found between GDF15 and the D:A:D Data Collection on Adverse Effects of Anti-HIV Drugs (D:A:D) score estimated CVR. CVR independent predictors were patient group (naive, HALS-, and HALS+) and cumulated protease inhibitor or nucleoside reverse transcriptase inhibitor exposure. Conclusions: PLWH, especially when cART-treated, has increased GDF15 levels-this increase is associated with dyslipidemia, insulin resistance, metabolic syndrome, HALS, and inflammation-related parameters. GDF15 is unassociated with CVR when age-adjusted.
C1 [Domingo, Pere; Mateo, Maria Gracia; Villarroya, Joan; Cereijo, Ruben; Gallego-Escuredo, Jose M.; Gutierrez, Maria del Mar; Mur, Isabel; Corbacho, Noemi] Inst Recerca Hosp Santa Creu & St Pau, Infect Dis Unit, Barcelona 08041, Spain.
   [Villarroya, Joan; Cereijo, Ruben; Domingo, Joan C.; Campderros, Laura; Gallego-Escuredo, Jose M.; Villarroya, Francesc; Giralt, Marta] Inst Biomed Univ Barcelona IBUB, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Dept Biochem & Mol Biomed, Barcelona 08028, Spain.
   [Torres, Ferran] Hosp Clin Barcelona, IDIBAPS, Biostat & Data Management Core Facil, Barcelona 08036, Spain.
   [Torres, Ferran] Univ Autonoma Barcelona, Fac Med, Biostat Unit, Barcelona 08193, Spain.
   [Vidal, Francesc] Univ Rovira & Virgili, Hosp Univ Joan XXIII, Dept Internal Med, Infect Dis Unit,IISPV, Tarragona 43003, Spain.
C3 Hospital of Santa Creu i Sant Pau; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; University of Barcelona; Hospital Clinic de
   Barcelona; IDIBAPS; Autonomous University of Barcelona; University of
   Barcelona; Universitat Rovira i Virgili; Institut d'Investigacio
   Sanitaria Pere Virgili (IISPV)
RP Domingo, P (corresponding author), Inst Recerca Hosp Santa Creu & St Pau, Infect Dis Unit, Barcelona 08041, Spain.
EM pdomingo@santpau.cat; mmateog@santpau.cat; jvillarroya@ub.edu;
   rcereijo@santpau.cat; Ferran.Torres@uab.cat; Ferran.Torres@uab.cat;
   jcdomingo@ub.edu; lcampderros@ub.edu; MGutierrezMa@santpau.cat;
   imur@santpau.cat; ncorbacho@santpau.cat; fvidal@comt.es;
   fvillarroya@ub.edu; mgiralt@ub.edu
RI Campderros, Laura/AAM-4550-2021; Domingo, Pere/CAH-9641-2022;
   Villarroya, Joan/W-4066-2018; Villarroya, Francesc/K-4357-2014; Rodero,
   Félix/Q-7880-2018; Cereijo, Rubén/C-2718-2014; Torres,
   Ferran/D-1296-2011; Cereijo, Ruben/K-3556-2017; Domingo Pedrol, Joan
   Carles/A-4856-2019; Giralt, Marta/A-4756-2013
OI Cereijo, Ruben/0000-0002-1108-230X; Campderros,
   Laura/0000-0003-4377-034X; Domingo Pedrol, Joan
   Carles/0000-0002-6356-0836; Giralt, Marta/0000-0001-7968-4190; Torres,
   Ferran/0000-0002-7355-7913; Domingo, Pere/0000-0003-1138-5770
FU Instituto de Salud Carlos III [PI14/0063, PI14/0700, PI016/0503,
   PI17/0420, PI17/0498, PI20/0106, PI20/0137]; AEI/FEDER, Ministerio de
   Sanidad, Politica Social e Igualdad [EC11-293]; Ministerio de Ciencia e
   Innovacion [IJC2018-037142-I, MCIN/AEI/10.13039/501100011033]; Programa
   de Suport als Grups de Recerca AGAUR [2014-SGR-250, 2017-SGR-948,
   RD012/0017/0014, RD12/0017/0005]; FEDER [GLD 1300168]
FX FundingThis work has been partially funded by Instituto de Salud Carlos
   III (PI14/0063, PI14/0700, PI016/0503, PI17/0420, PI17/0498, PI20/0106
   and PI20/0137) AEI/FEDER, Ministerio de Sanidad, Politica Social e
   Igualdad (EC11-293), Ministerio de Ciencia e Innovacion (grant
   IJC2018-037142-I, funded by the MCIN/AEI/10.13039/501100011033),
   Programa de Suport als Grups de Recerca AGAUR (2014-SGR-250,
   2017-SGR-948), and Red de Investigacion en SIDA RD012/0017/0014,
   RD12/0017/0005 integrated in the National RDI Plan and cofinanced by the
   ISCIII-Subdireccion General de Evaluacion and FEDER; FEDER (Fondo
   Europeo de desarrollo Regional; otra manera de hacer Europa), and by the
   Gilead Fellowship Program (I Convocatoria de Proyectos de Investigacion
   en VIH y Hepatitis 2013, GLD 1300168, and II Convocatoria de Proyectos
   de Investigacion en VIH y Hepatitis GLD 2014/00923. The funding sources
   were not involved in the design of the study, in the collection and
   analysis of data or in writing the report. All authors had access to the
   data used in the analyses and the lead author reviewed the full data
   report. The full study data were available to all authors. The decision
   to submit the paper for publication was made by P.D., M.G.M., F.V. and
   M.G.
CR Amer Diabet Assoc, 2021, DIABETES CARE, V44, pS15, DOI 10.2337/dc21-S002
   Anadol E, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0191118
   Anand IS, 2010, CIRCULATION, V122, P1387, DOI 10.1161/CIRCULATIONAHA.109.928846
   [Anonymous], 1993, Morbidity and Mortality Weekly Report, V41, P1
   Barnes RP, 2017, CURR ATHEROSCLER REP, V19, DOI 10.1007/s11883-017-0652-3
   Berezin AE, 2017, DIAB MET SYND CLIN R, V11, pS201, DOI 10.1016/j.dsx.2016.12.032
   Boccara F, 2013, J AM COLL CARDIOL, V61, P511, DOI 10.1016/j.jacc.2012.06.063
   Brothers TD, 2014, CURR OPIN HIV AIDS, V9, P412, DOI 10.1097/COH.0000000000000070
   Chambless LE, 2011, STAT MED, V30, P22, DOI 10.1002/sim.4026
   Cubero JM, 2011, METAB SYNDR RELAT D, V9, P345, DOI 10.1089/met.2010.0129
   D'Agostino RB, 2008, CIRCULATION, V117, P743, DOI 10.1161/CIRCULATIONAHA.107.699579
   Deeks SG, 2013, LANCET, V382, P1525, DOI 10.1016/S0140-6736(13)61809-7
   deFilippi C, 2018, JAIDS-J ACQ IMM DEF, V78, P105, DOI 10.1097/QAI.0000000000001644
   Ding Q, 2009, ENDOCRINOLOGY, V150, P1688, DOI 10.1210/en.2008-0952
   Domingo P, 2018, CLIN NUTR, V37, P1340, DOI 10.1016/j.clnu.2017.05.032
   Domingo P, 2014, JAIDS-J ACQ IMM DEF, V66, P457, DOI 10.1097/QAI.0000000000000205
   Domingo P, 2010, CLIN INFECT DIS, V50, P1033, DOI 10.1086/651117
   Dostálová I, 2010, NUTR METAB, V7, DOI 10.1186/1743-7075-7-34
   Dostálová I, 2009, EUR J ENDOCRINOL, V161, P397, DOI 10.1530/EJE-09-0417
   Eggers KM, 2010, AM HEART J, V160, P88, DOI 10.1016/j.ahj.2010.05.002
   Elion RA, 2018, JAIDS-J ACQ IMM DEF, V78, P62, DOI [10.1097/qai.0000000000001642, 10.1097/QAI.0000000000001642]
   Friis-Moller N, 2003, NEW ENGL J MED, V349, P1993, DOI 10.1056/NEJMoa030218
   Friis-Moller N, 2010, EUR J CARDIOV PREV R, V17, P491, DOI 10.1097/HJR.0b013e328336a150
   Giannarelli C, 2011, ATHEROSCLEROSIS, V219, P384, DOI 10.1016/j.atherosclerosis.2011.06.003
   Gomez-Sucerquia LJ, 2012, ANTIVIR RES, V94, P232, DOI 10.1016/j.antiviral.2012.04.003
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Khan SQ, 2009, EUR HEART J, V30, P1057, DOI 10.1093/eurheartj/ehn600
   Koethe JR, 2020, NAT REV DIS PRIMERS, V6, DOI 10.1038/s41572-020-0181-1
   Kralisch S, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21197214
   Levey AS, 2009, ANN INTERN MED, V150, P604, DOI 10.7326/0003-4819-150-9-200905050-00006
   Lichtenstein KA, 2001, AIDS, V15, P1389, DOI 10.1097/00002030-200107270-00008
   Lind L, 2009, EUR HEART J, V30, P2346, DOI 10.1093/eurheartj/ehp261
   Lockhart SM, 2020, ENDOCR REV, V41, DOI 10.1210/endrev/bnaa007
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Minamino T, 2009, NAT MED, V15, P1082, DOI 10.1038/nm.2014
   Monroe AK, 2016, AIDS, V30, P2075, DOI 10.1097/QAD.0000000000001163
   Montero R, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0148709
   Mullican SE, 2018, TRENDS ENDOCRIN MET, V29, P560, DOI 10.1016/j.tem.2018.05.002
   Patel S, 2019, CELL METAB, V29, P707, DOI 10.1016/j.cmet.2018.12.016
   Rohatgi A, 2012, CLIN CHEM, V58, P172, DOI 10.1373/clinchem.2011.171926
   Savès M, 2002, CLIN INFECT DIS, V34, P1396, DOI 10.1086/339866
   Schernthaner-Reiter MH, 2019, NUTR METAB CARDIOVAS, V29, P334, DOI 10.1016/j.numecd.2018.12.008
   Scherzer R, 2018, CIRC-HEART FAIL, V11, DOI 10.1161/CIRCHEARTFAILURE.117.004312
   Secemsky EA, 2015, JACC-HEART FAIL, V3, P591, DOI 10.1016/j.jchf.2015.03.007
   Rossi JLS, 2022, DIABETES-METAB RES, V38, DOI 10.1002/dmrr.3502
   Triant VA, 2007, J CLIN ENDOCR METAB, V92, P2506, DOI 10.1210/jc.2006-2190
   Triant VA, 2018, CIRCULATION, V137, P2203, DOI [10.1161/CIRCULATIONAHA.117.028975, 10.1161/circulationaha.117.028975]
   Wang DD, 2021, NAT REV ENDOCRINOL, V17, P592, DOI 10.1038/s41574-021-00529-7
   Wang J, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.119.012826
   Yatsuga S, 2015, ANN NEUROL, V78, P814, DOI 10.1002/ana.24506
   Young J, 2015, JAIDS-J ACQ IMM DEF, V69, P413, DOI 10.1097/QAI.0000000000000662
NR 51
TC 5
Z9 5
U1 0
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD FEB
PY 2022
VL 11
IS 3
AR 549
DI 10.3390/jcm11030549
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ZF8SS
UT WOS:000759840200001
PM 35160008
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kim, JS
   Kim, YJ
   Ahn, SH
   Kim, BJ
AF Kim, Jong S.
   Kim, Yeon-Jung
   Ahn, Sung-Ho
   Kim, Bum J.
TI Location of cerebral atherosclerosis: Why is there a difference between
   East and West?
SO INTERNATIONAL JOURNAL OF STROKE
LA English
DT Review
DE Intracranial atherosclerosis; risk factor; metabolic syndrome; gene;
   Asia
ID CLASSIC RISK-FACTORS; METABOLIC SYNDROME; INTRACRANIAL ATHEROSCLEROSIS;
   RACIAL-DIFFERENCES; MOYAMOYA-DISEASE; GENETIC VARIANT;
   CEREBROVASCULAR-DISEASE; GENOMEWIDE ASSOCIATION; ARTERY ATHEROSCLEROSIS;
   EXTRACRANIAL ARTERIES
AB Intracranial atherosclerosis is more prevalent in Asian patients, whereas extracranial atherosclerosis is more common in individuals from western countries. The reasons for this discrepancy remain unknown. We reviewed the relevant literature and discussed the currently available information. Although the study population, diagnostic modality, and risk factor definitions differ between studies, hypercholesterolemia is more correlated with extracranial atherosclerosis than intracranial atherosclerosis. The difference in hypercholesterolemia prevalence is one of the main reasons for racial differences. Intracranial arteries contain higher antioxidant level than extracranial arteries and may be more vulnerable to risk factors for antioxidant depletion (e.g., metabolic syndrome and diabetes mellitus). Intracranial arteries may be vulnerable to factors associated with hemodynamic stress (e.g., advanced, salt-retaining hypertension and arterial tortuosity) because of a smaller diameter, thinner media and adventitia, and fewer elastic medial fibers than extracranial arteries. Additionally, non-atherosclerotic arterial diseases (e.g., moyamoya disease) that commonly occur in the intracranial arteries of East Asians may contaminate the reports of intracranial atherosclerosis cases. Genes, including RNF 213 or those associated with high salt sensitivity, may also explain racial differences in atherosclerotic location. To understand racial differences, further well-designed studies on various risk and genetic factors should be performed in patients with cerebral atherosclerosis. Additionally, improvements in diagnostic accuracy via advancements in imaging technologies and increased genetic data will aid in the differentiation of atherosclerosis from non-atherosclerotic intracranial diseases.
C1 [Kim, Jong S.; Kim, Yeon-Jung; Ahn, Sung-Ho; Kim, Bum J.] Univ Ulsan, Dept Neurol, Asan Med Ctr, Seoul, South Korea.
C3 University of Ulsan; Asan Medical Center
RP Kim, JS (corresponding author), Univ Ulsan, Dept Neurol, Asan Med Ctr, Coll Med, Asanbyeongwon Gil 86, Seoul 138736, South Korea.
EM jongskim@amc.seoul.kr
RI Kim, Bum Joon/S-2156-2017
FU Ministry of Health, Welfare and Family Affairs, Republic of Korea
   [HI14C1985]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This study
   was supported by a grant from Ministry of Health, Welfare and Family
   Affairs, Republic of Korea (HI14C1985).
CR Abboud S, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0001043
   Bang OY, 2007, NEUROLOGY, V68, P1931, DOI 10.1212/01.wnl.0000263186.20988.9f
   Bang OY, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0130663
   Bang OY, 2014, J STROKE, V16, P27
   Bang OY, 2005, NEUROLOGY, V65, P296, DOI 10.1212/01.wnl.0000168862.09764.9f
   CAPLAN LR, 1986, STROKE, V17, P648, DOI 10.1161/01.STR.17.4.648
   Chen HB, 2015, J STROKE CEREBROVASC, V24, P2632, DOI 10.1016/j.jstrokecerebrovasdis.2015.07.019
   Chen HB, 2015, J STROKE CEREBROVASC, V24, P852, DOI 10.1016/j.jstrokecerebrovasdis.2014.12.008
   CHENG MK, 1982, STROKE, V13, P249, DOI 10.1161/01.STR.13.2.249
   Choi YJ, 2015, J STROKE, V17, P238, DOI 10.5853/jos.2015.17.3.238
   Chutinet A, 2012, J STROKE CEREBROVASC, V21, P379, DOI 10.1016/j.jstrokecerebrovasdis.2010.10.002
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Conklin J, 2014, ANN NEUROL, V76, P899, DOI 10.1002/ana.24285
   Cossrow N, 2004, J CLIN ENDOCR METAB, V89, P2590, DOI 10.1210/jc.2004-0339
   D'Armiento FP, 2001, STROKE, V32, P2472, DOI 10.1161/hs1101.098520
   De Silva DA, 2009, J STROKE CEREBROVASC, V18, P424, DOI 10.1016/j.jstrokecerebrovasdis.2009.01.010
   Fujimura M, 2014, J STROKE, V16, P65
   GORELICK PB, 1984, NEUROLOGY, V34, P54, DOI 10.1212/WNL.34.1.54
   Heyden S, 1970, STROKE, V1, P363, DOI 10.1161/01.STR.1.5.363
   Hoang Khiet C, 2007, J Cardiometab Syndr, V2, P276, DOI 10.1111/j.1559-4564.2007.07491.x
   Huang YC, 2009, SURG NEUROL, V72, P20, DOI 10.1016/j.surneu.2008.10.002
   Ikram MA, 2009, NEW ENGL J MED, V360, P1718, DOI 10.1056/NEJMoa0900094
   Imamura T, 2009, STROKE, V40, P382, DOI 10.1161/STROKEAHA.108.529537
   INGALL TJ, 1991, ARCH NEUROL-CHICAGO, V48, P687, DOI 10.1001/archneur.1991.00530190033011
   INZITARI D, 1990, ARCH NEUROL-CHICAGO, V47, P1080, DOI 10.1001/archneur.1990.00530100042012
   Jung KH, 2012, CIRC-CARDIOVASC QUAL, V5, P327, DOI 10.1161/CIRCOUTCOMES.111.963736
   Kalita J, 2013, NEUROL RES, V35, P429, DOI 10.1179/1743132813Y.0000000161
   Kalita J, 2011, DIS MARKERS, V31, P191, DOI [10.1155/2011/232490, 10.3233/DMA-2011-0810]
   Kim BJ, 2015, INT J STROKE, V10, P1081, DOI 10.1111/ijs.12525
   Kim JS, 2012, STROKE, V43, P3313, DOI 10.1161/STROKEAHA.112.658500
   Kim JS, 1999, EUR NEUROL, V42, P150, DOI 10.1159/000008090
   Kim YD, 2010, YONSEI MED J, V51, P318, DOI 10.3349/ymj.2010.51.3.318
   Kim YD, 2009, NEUROEPIDEMIOLOGY, V32, P201, DOI 10.1159/000195690
   Kokubo Y, 2014, HYPERTENSION, V63, P655, DOI 10.1161/HYPERTENSIONAHA.113.00543
   Krex D, 2004, CEREBROVASC DIS, V18, P104, DOI 10.1159/000079257
   KULLER L, 1971, AM J EPIDEMIOL, V93, P1
   Kuroda S, 2008, LANCET NEUROL, V7, P1056, DOI 10.1016/S1474-4422(08)70240-0
   KUROZUMI T, 1984, BRIT J EXP PATHOL, V65, P355
   Kwon JY, 2015, J NEUROL SCI, V358, P371, DOI 10.1016/j.jns.2015.09.368
   Lapenna D, 2015, ATHEROSCLEROSIS, V238, P190, DOI 10.1016/j.atherosclerosis.2014.11.028
   Lee AY, 2012, AM J PHYSIOL-HEART C, V302, pH873, DOI 10.1152/ajpheart.00463.2011
   Lee S, 2006, DIABETES CARE, V29, P51, DOI 10.2337/diacare.29.01.06.dc05-0952
   Lei CY, 2014, J STROKE CEREBROVASC, V23, P1112, DOI 10.1016/j.jstrokecerebrovasdis.2013.09.024
   LEUNG SY, 1993, STROKE, V24, P779, DOI 10.1161/01.STR.24.6.779
   Li MM, 2015, CLIN LAB, V61, P1727, DOI 10.7754/Clin.Lab.2015.150419
   Liu WY, 2012, NEUROL MED-CHIR, V52, P299, DOI 10.2176/nmc.52.299
   Liu ZZ, 2008, CLIN CHIM ACTA, V389, P40, DOI 10.1016/j.cca.2007.11.018
   López-Cancio E, 2012, STROKE, V43, P2712, DOI 10.1161/STROKEAHA.112.661702
   Malek AM, 1999, JAMA-J AM MED ASSOC, V282, P2035, DOI 10.1001/jama.282.21.2035
   Matsuda M, 2002, J BIOL CHEM, V277, P37487, DOI 10.1074/jbc.M206083200
   Miyawaki S, 2013, STROKE, V44, P2894, DOI 10.1161/STROKEAHA.113.002477
   Miyawaki S, 2012, STROKE, V43, P3371, DOI 10.1161/STROKEAHA.112.663864
   MOOSSY J, 1959, NEUROLOGY, V9, P569, DOI 10.1212/WNL.9.9.569
   Munshi A, 2010, J NEUROL SCI, V296, P34, DOI 10.1016/j.jns.2010.06.013
   Napoli C, 1999, CIRCULATION, V99, P2003, DOI 10.1161/01.CIR.99.15.2003
   NISHIMARU K, 1984, STROKE, V15, P56, DOI 10.1161/01.STR.15.1.56
   Oguri M, 2011, J MED GENET, V48, P787, DOI 10.1136/jmg.2010.088138
   Palmieri VO, 2006, J NUTR, V136, P3022, DOI 10.1093/jn/136.12.3022
   Park Hyun-Young, 2008, J Stroke Cerebrovasc Dis, V17, P401, DOI 10.1016/j.jstrokecerebrovasdis.2008.06.004
   Park JH, 2007, EUR J NEUROL, V14, P379, DOI 10.1111/j.1468-1331.2007.01682.x
   Park JH, 2011, STROKE, V42, P3040, DOI 10.1161/STROKEAHA.111.620104
   Phan TG, 2012, STROKE, V43, P1596, DOI 10.1161/STROKEAHA.111.645499
   Rhee EJ, 2015, ENDOCRINOL METAB, V30, P263, DOI 10.3803/EnM.2015.30.3.263
   Rincon F, 2009, CEREBROVASC DIS, V28, P65, DOI 10.1159/000219299
   Ritz K, 2014, CIRCULATION, V130, P1407, DOI 10.1161/CIRCULATIONAHA.114.011147
   SACCO RL, 1995, STROKE, V26, P14, DOI 10.1161/01.STR.26.1.14
   Siddiq F, 2012, NEUROEPIDEMIOLOGY, V38, P148, DOI 10.1159/000335498
   SOLBERG LA, 1972, ATHEROSCLEROSIS, V16, P141, DOI 10.1016/0021-9150(72)90048-2
   Sung YF, 2015, J AM HEART ASSOC, V4, DOI 10.1161/JAHA.115.002692
   Suwanwela NC, 2003, NEUROEPIDEMIOLOGY, V22, P37, DOI 10.1159/000067112
   Thammaroj J, 2005, NEUROIMAG CLIN N AM, V15, P273, DOI 10.1016/j.nic.2005.07.001
   Uehara T, 1998, CEREBROVASC DIS, V8, P267, DOI 10.1159/000015864
   Valsamakis G, 2003, DIABETES OBES METAB, V5, P131, DOI 10.1046/j.1463-1326.2003.00254.x
   van den Herik EG, 2012, INT J STROKE, V7, P219, DOI 10.1111/j.1747-4949.2011.00658.x
   van Rijn MJE, 2006, STROKE, V37, P2930, DOI 10.1161/01.STR.0000248760.67039.2b
   Vgontzas AN, 2005, SLEEP MED REV, V9, P211, DOI 10.1016/j.smrv.2005.01.006
   Villaneuva ATC, 2005, SLEEP MED REV, V9, P419, DOI 10.1016/j.smrv.2005.04.005
   Wang R, 2010, J APPL GENET, V51, P87, DOI 10.1007/BF03195715
   WEBER G, 1985, PATHOL RES PRACT, V180, P353
   Wityk RJ, 1996, STROKE, V27, P1974, DOI 10.1161/01.STR.27.11.1974
   Yang WQ, 2014, EUR J RADIOL, V83, pE49, DOI 10.1016/j.ejrad.2013.10.003
   YASAKA M, 1993, STROKE, V24, P206, DOI 10.1161/01.STR.24.2.206
NR 82
TC 60
Z9 65
U1 1
U2 19
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1747-4930
EI 1747-4949
J9 INT J STROKE
JI Int. J. Stroke
PD JAN
PY 2018
VL 13
IS 1
BP 35
EP 46
DI 10.1177/1747493016647736
PG 12
WC Clinical Neurology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Cardiovascular System & Cardiology
GA FP8CU
UT WOS:000417868600006
PM 27145795
DA 2025-06-11
ER

PT J
AU Waldstein, SR
   Katzel, LI
AF Waldstein, SR
   Katzel, LI
TI Interactive relations of central versus total obesity and blood pressure
   to cognitive function
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
DE central obesity; blood pressure; cognitive function; cognition;
   neuropsychology
ID BODY-MASS INDEX; METABOLIC SYNDROME; RISK-FACTORS; STROKE; STRESS;
   ABNORMALITIES; HYPERTENSION; REACTIVITY; MORTALITY; RELEVANCE
AB Objective: To examine the potential interactive relations of central versus total obesity and blood pressure ( BP) to cognitive function.
   Method: In all, 90 healthy, stroke, and dementia-free middle-aged and older adults ( ages 54-81 years; 63% male; 93% White) underwent biomedical and neuropsychological assessment. Relations of central obesity ( assessed by waist circumference (WC)) and systolic or diastolic BP to cognitive function were examined in multiple regression models. Next, body mass index (BMI) was substituted for WC in the models.
   Results: After statistical adjustment for age, education, gender, and other potential confounders including components of the metabolic syndrome (depending on the model), significant interactions of WC and systolic (or diastolic) BP were noted for the Grooved Pegboard-Dominant Hand and Stroop Interference scores, with marginally significant results for Grooved Pegboard Nondominant Hand. In general, individuals with greater WC and higher BP performed most poorly on these measures. Similar results were obtained for BMI.
   Conclusion: Independent of other confounders including facets of the metabolic syndrome, the combination of greater WC (or BMI) and higher (systolic or diastolic) BP was associated with diminished performance on tests of motor speed and manual dexterity, and executive function (i.e. response inhibition) accounting for 3-13% of the variance in these measures. In healthy older adults, there are similar, negative relations of central and total obesity to cognitive function that are potentiated by higher BP levels.
C1 Univ Maryland Baltimore Cty, Dept Psychol, Baltimore, MD 21250 USA.
   Univ Maryland, Sch Med, Div Gerontol, Dept Med, Baltimore, MD 21201 USA.
   Baltimore Vet Affairs Med Ctr, Geriatr Res Educ & Clin Ctr, Baltimore, MD USA.
C3 University System of Maryland; University of Maryland Baltimore County;
   University System of Maryland; University of Maryland Baltimore; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Baltimore VA Medical Center; Geriatric Research Education & Clinical
   Center
RP Univ Maryland Baltimore Cty, Dept Psychol, 1000 Hilltop Circle, Baltimore, MD 21250 USA.
EM waldstei@umbc.edu
CR Beck A. T., 1987, Beck depression inventory
   Björntorp P, 2000, INT J OBESITY, V24, pS80, DOI 10.1038/sj.ijo.0801285
   CHELUNE GJ, 1986, INT J EAT DISORDER, V5, P701, DOI 10.1002/1098-108X(198605)5:4<701::AID-EAT2260050409>3.0.CO;2-7
   Das UN, 2004, CURR HYPERTENS REP, V6, P66, DOI 10.1007/s11906-004-0014-8
   DROYVOLD WB, 2005, INT J OBESITY, V29, P950
   Elias MF, 2003, INT J OBESITY, V27, P260, DOI 10.1038/sj.ijo.802225
   ELIAS MF, 1993, AM J EPIDEMIOL, V138, P353, DOI 10.1093/oxfordjournals.aje.a116868
   Everson SA, 2001, STROKE, V32, P1263, DOI 10.1161/01.STR.32.6.1263
   Gunning-Dixon FM, 2000, NEUROPSYCHOLOGY, V14, P224, DOI 10.1037//0894-4105.14.2.224
   Gustafson D, 2003, ARCH INTERN MED, V163, P1524, DOI 10.1001/archinte.163.13.1524
   Haan MN, 2004, ANNU REV PUBL HEALTH, V25, P1, DOI 10.1146/annurev.publhealth.25.101802.122951
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Kilander L, 1997, J INTERN MED, V242, P313, DOI 10.1046/j.1365-2796.1997.00196.x
   Kip KE, 2004, CIRCULATION, V109, P706, DOI 10.1161/01.CIR.0000115514.44135.A8
   Kurth T, 2002, ARCH INTERN MED, V162, P2557, DOI 10.1001/archinte.162.22.2557
   Lewington S, 2002, LANCET, V360, P1903, DOI 10.1016/S0140-6736(02)11911-8
   Lezak MD, 2004, Neuropsychological assessment, V4th
   Li XL, 2002, NEUROSCIENCE, V113, P607, DOI 10.1016/S0306-4522(02)00162-8
   Meyer JS, 2000, ANN NY ACAD SCI, V903, P411, DOI 10.1111/j.1749-6632.2000.tb06393.x
   Pi-Sunyer FX, 1998, AM J CLIN NUTR, V68, P899
   Ren J, 2004, J ENDOCRINOL, V181, P1, DOI 10.1677/joe.0.1810001
   Ribeiro FF, 2003, OBES RES, V11, P1488, DOI 10.1038/oby.2003.199
   ROSENGREN A, 2003, J CARDIOVASC RISK, V10, P443
   Sapolsky RM, 1999, EXP GERONTOL, V34, P721, DOI 10.1016/S0531-5565(99)00047-9
   Shen BJ, 2003, AM J EPIDEMIOL, V157, P701, DOI 10.1093/aje/kwg045
   Song YM, 2004, STROKE, V35, P831, DOI 10.1161/01.STR.0000119386.22691.1C
   SORENSEN TIA, 1982, HUM BIOL, V54, P765
   Spielberger C.D., 1979, PRELIMINARY MANUAL S
   Suk SH, 2003, STROKE, V34, P1586, DOI 10.1161/01.STR.0000075294.98582.2F
   Toni R, 2004, J ENDOCRINOL INVEST, V27, P182, DOI 10.1007/BF03346266
   WALDSTEIN SR, 1991, PSYCHOL BULL, V110, P451, DOI 10.1037/0033-2909.110.3.451
   Waldstein SR, 2004, STROKE, V35, P1294, DOI 10.1161/01.STR.0000127774.43890.5b
   Waldstein SR, 2001, NEUROPSYCHOLOGY OF CARDIOVASCULAR DISEASE, P15
   Wilson CJ, 2002, J AM GERIATR SOC, V50, P2041, DOI 10.1046/j.1532-5415.2002.50619.x
   Yaffe K, 2003, NEUROLOGY, V61, P76, DOI 10.1212/01.WNL.0000073620.42047.D7
NR 35
TC 150
Z9 174
U1 0
U2 18
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD JAN
PY 2006
VL 30
IS 1
BP 201
EP 207
DI 10.1038/sj.ijo.0803114
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 992SQ
UT WOS:000233904700030
PM 16231030
DA 2025-06-11
ER

PT J
AU Litwin, M
   Feber, J
AF Litwin, Mieczyslaw
   Feber, Janusz
TI Origins of Primary Hypertension in Children Early Vascular or Biological
   Aging?
SO HYPERTENSION
LA English
DT Review
DE adolescent; brachial artery; cardiovascular disease; dilation; metabolic
   syndrome
ID INTIMA-MEDIA THICKNESS; BODY-MASS INDEX; ASSISTED REPRODUCTIVE
   TECHNOLOGIES; CARDIOVASCULAR RISK-FACTORS; ELEVATED BLOOD-PRESSURE;
   PULSE-WAVE VELOCITY; ARTERIAL STIFFNESS; METABOLIC-SYNDROME; OXIDATIVE
   STRESS; PHYSICAL-ACTIVITY
AB Although relatively rare in childhood, primary hypertension (PH) is thought to have originated in childhood and may be even determined perinatally. PH prevalence increases in school-age children and affects 11% of 18-year-old adolescents. Associated with metabolic risk factors, elevated blood pressure in childhood is carried into adulthood. Analysis of the phenotype of hypertensive children has revealed that PH is a complex of anthropometric and neuro-immuno-metabolic abnormalities, typically found in hypertensive adults. Children with elevated blood pressure have shown signs of accelerated biological development, which are closely associated with further development of PH, metabolic syndrome, and cardiovascular disease in adulthood. At the time of diagnosis, hypertensive children were reported to have significant arterial remodelling expressed as significantly increased carotid intima-media thickness, increased stiffness of large arteries, lower area of microcirculation, and decreased endothelial function. These changes indicate that their biological age is 4 to 5 years older than their normotensive peers. All these abnormalities are typical features of early vascular aging described in adults with PH. However, as these early vascular changes in hypertensive children are closely associated with features of accelerated biological development and neuro-immuno-metabolic abnormalities observed in older subjects, it seems that PH in childhood is not only an early vascular aging event, but also an early biological maturation phenomenon.
C1 [Litwin, Mieczyslaw] Childrens Mem Hlth Inst, Dept Nephrol & Arterial Hypertens, Warsaw, Poland.
   [Feber, Janusz] Childrens Mem Hlth Inst, Div Nephrol, Dept Pediat, Warsaw, Poland.
   [Litwin, Mieczyslaw] Ctr Postgrad Med Educ, Chair Pediat Nephrol, Warsaw, Poland.
C3 Children's Memorial Health Institute; Children's Memorial Health
   Institute; Centre of Postgraduate Medical Education - Poland
RP Litwin, M (corresponding author), Childrens Mem Hlth Inst, Dept Nephrol Kidney Transplantat & Arterial Hyper, Aleja Dzieci Polskich 20, PL-04730 Warsaw, Poland.
EM m.litwin@ipczd.pl
RI Feber, Janusz/LTD-8835-2024; Litwin, Mieczyslaw/L-4648-2017
OI Litwin, Mieczyslaw/0000-0002-5241-2483
CR Abreu AP, 2016, LANCET DIABETES ENDO, V4, P254, DOI 10.1016/S2213-8587(15)00418-0
   Aggoun Y, 2008, EUR HEART J, V29, P792, DOI 10.1093/eurheartj/ehm633
   [Anonymous], 2017, BMJ BRIT MED J, DOI DOI 10.1136/BMJ.J3311
   Arai Y, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00142
   Baker SE, 2018, HYPERTENSION, V72, P1236, DOI 10.1161/HYPERTENSIONAHA.118.11550
   BARKER DJP, 1989, BMJ-BRIT MED J, V298, P564, DOI 10.1136/bmj.298.6673.564
   Bektas A, 2018, EXP GERONTOL, V105, P10, DOI 10.1016/j.exger.2017.12.015
   Calhaz-Jorge C, 2016, HUM REPROD, V31, P1638, DOI 10.1093/humrep/dew151
   Chen FF, 2019, OBESITY, V27, P837, DOI 10.1002/oby.22426
   Craig A, 2018, FREE RADICAL RES, V52, P180, DOI 10.1080/10715762.2017.1421314
   de Lucia C, 2019, INT J BIOCHEM CELL B, V108, P29, DOI 10.1016/j.biocel.2019.01.004
   Ding WQ, 2018, J EPIDEMIOL, V28, P19, DOI 10.2188/jea.JE20160141
   Doyon A, 2013, HYPERTENSION, V62, P550, DOI 10.1161/HYPERTENSIONAHA.113.01297
   Ekelund U, 2009, AM J CLIN NUTR, V89, P90, DOI 10.3945/ajcn.2008.26649
   Falkner B, 2006, J PEDIATR-US, V148, P195, DOI 10.1016/j.jpeds.2005.10.030
   Falkner B, 2020, HYPERTENSION, V75, P1142, DOI 10.1161/HYPERTENSIONAHA.119.14059
   Farpour-Lambert NJ, 2009, J AM COLL CARDIOL, V54, P2396, DOI 10.1016/j.jacc.2009.08.030
   Feig DI, 2008, JAMA-J AM MED ASSOC, V300, P924, DOI 10.1001/jama.300.8.924
   Feig DI, 2003, HYPERTENSION, V42, P247, DOI 10.1161/01.HYP.0000085858.66548.59
   Ferrucci L, 2005, BLOOD, V105, P2294, DOI 10.1182/blood-2004-07-2599
   Flechtner-Mors M, 2015, AM J CARDIOL, V115, P1587, DOI 10.1016/j.amjcard.2015.02.063
   Flechtner-Mors M, 2012, HORM RES PAEDIAT, V77, P19, DOI 10.1159/000334147
   Flynn JT, 2005, PEDIATR NEPHROL, V20, P961, DOI 10.1007/s00467-005-1855-3
   Frontini MG, 2003, INT J OBESITY, V27, P1398, DOI 10.1038/sj.ijo.0802422
   Gackowska L, 2020, J HYPERTENS, V38, P692, DOI 10.1097/HJH.0000000000002328
   Gackowska L, 2018, J HYPERTENS, V36, P2148, DOI 10.1097/HJH.0000000000001811
   Gackowska L, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/742646
   Gerhard-Herman M, 2012, HYPERTENSION, V59, P92, DOI 10.1161/HYPERTENSIONAHA.111.180919
   Goonasekera CDA, 1997, J HYPERTENS, V15, P901, DOI 10.1097/00004872-199715080-00015
   Gordon LB, 2014, CIRCULATION, V130, P27, DOI 10.1161/CIRCULATIONAHA.113.008285
   Guo XY, 2017, FERTIL STERIL, V107, P622, DOI 10.1016/j.fertnstert.2016.12.007
   Gupta-Malhotra M, 2018, BLOOD PRESSURE, V27, P289, DOI 10.1080/08037051.2018.1463818
   Gupta-Malhotra M, 2015, AM J HYPERTENS, V28, P73, DOI 10.1093/ajh/hpu083
   Guzik TJ, 2017, HYPERTENSION, V70, P660, DOI 10.1161/HYPERTENSIONAHA.117.07802
   Halldorsson TI, 2011, HYPERTENSION, V58, P8, DOI 10.1161/HYPERTENSIONAHA.111.170985
   Hamczyk MR, 2020, J AM COLL CARDIOL, V75, P919, DOI 10.1016/j.jacc.2019.11.062
   Higaki A, 2019, CURR HYPERTENS REP, V21, DOI 10.1007/s11906-019-0907-1
   Hulanicka B, 2007, ECON HUM BIOL, V5, P48, DOI 10.1016/j.ehb.2006.12.001
   Imai CM, 2013, ANN MED, V45, P545, DOI 10.3109/07853890.2013.852347
   Itani HA, 2016, HYPERTENSION, V68, P123, DOI 10.1161/HYPERTENSIONAHA.116.07237
   Juhola J, 2013, CIRCULATION, V128, P217, DOI 10.1161/CIRCULATIONAHA.113.001614
   Juhola J, 2011, J PEDIATR-US, V159, P584, DOI 10.1016/j.jpeds.2011.03.021
   Julius S, 2000, HYPERTENSION, V35, P807, DOI 10.1161/01.HYP.35.3.807
   JULIUS S, 1991, J HYPERTENS, V9, P77, DOI 10.1097/00004872-199101000-00012
   KATZ SH, 1980, HYPERTENSION, V2, pI55, DOI 10.1161/01.HYP.2.4_Pt_2.I55
   Kent AL, 2009, PEDIATR NEPHROL, V24, P141, DOI 10.1007/s00467-008-0916-9
   Khan AH, 2019, BBA-MOL BASIS DIS, V1865, P1745, DOI 10.1016/j.bbadis.2018.09.001
   Kim DH, 2013, HYPERTENSION, V62, P27, DOI 10.1161/HYPERTENSIONAHA.113.01453
   Kirkwood TBL, 2005, CELL, V120, P437, DOI 10.1016/j.cell.2005.01.027
   Kirkwood TBL, 2017, EXP PHYSIOL, V102, P1067, DOI 10.1113/EP086205
   Kivimäki M, 2008, AM J CLIN NUTR, V87, P1876, DOI 10.1093/ajcn/87.6.1876
   Köchli S, 2019, HYPERTENSION, V73, P153, DOI 10.1161/HYPERTENSIONAHA.118.11872
   Kollias A, 2014, J HYPERTENS, V32, P2315, DOI 10.1097/HJH.0000000000000384
   Krmar RT, 2008, PEDIATR TRANSPLANT, V12, P412, DOI 10.1111/j.1399-3046.2007.00837.x
   Kruger R, 2021, PEDIATR NEPHROL, V36, P1087, DOI 10.1007/s00467-020-04593-5
   Kuh D, 2007, J GERONTOL A-BIOL, V62, P717, DOI 10.1093/gerona/62.7.717
   Kulsum-Mecci N, 2017, J CLIN HYPERTENS, V19, P221, DOI 10.1111/jch.12892
   LAUER RM, 1984, HYPERTENSION, V6, P307, DOI 10.1161/01.HYP.6.3.307
   Laurent S, 2019, HYPERTENSION, V74, P218, DOI 10.1161/HYPERTENSIONAHA.119.12655
   Lawn JE, 2010, BMC PREGNANCY CHILDB, V10, DOI 10.1186/1471-2393-10-S1-S1
   LEVER AF, 1992, J HYPERTENS, V10, P101, DOI 10.1097/00004872-199202000-00001
   Li Y, 2020, J AM HEART ASSOC, V9, DOI 10.1161/JAHA.119.015097
   Litwin M, 2005, J AM SOC NEPHROL, V16, P1494, DOI 10.1681/ASN.2004110932
   Litwin M, 2004, PEDIATR NEPHROL, V19, P767, DOI 10.1007/s00467-004-1480-6
   Litwin M, 2007, AM J HYPERTENS, V20, P875, DOI 10.1016/j.amjhyper.2007.03.005
   Litwin M, 2008, NEPHROL DIAL TRANSPL, V23, P2552, DOI 10.1093/ndt/gfn083
   Litwin M, 2006, PEDIATR NEPHROL, V21, P811, DOI 10.1007/s00467-006-0068-8
   Litwin M, 2019, PEDIATR NEPHROL, V34, P703, DOI 10.1007/s00467-018-4136-7
   Litwin M, 2018, PEDIATR NEPHROL, V33, P83, DOI 10.1007/s00467-017-3739-8
   Litwin M, 2016, CAN J CARDIOL, V32, P642, DOI 10.1016/j.cjca.2016.02.064
   Litwin M, 2016, PEDIATR NEPHROL, V31, P185, DOI 10.1007/s00467-015-3065-y
   Litwin M, 2013, HYPERTENSION, V61, P431, DOI 10.1161/HYPERTENSIONAHA.111.00181
   Litwin M, 2010, PEDIATR NEPHROL, V25, P2489, DOI 10.1007/s00467-010-1626-7
   Litwin M, 2010, PEDIATR NEPHROL, V25, P1711, DOI 10.1007/s00467-010-1548-4
   Litwin M, 2010, PEDIATR RES, V67, P419, DOI 10.1203/PDR.0b013e3181d00b5b
   Litwin M, 2009, PEDIATR NEPHROL, V24, P707, DOI 10.1007/s00467-008-0962-3
   Lona G, 2020, HYPERTENSION, V76, P450, DOI 10.1161/HYPERTENSIONAHA.120.14695
   Lurbe E, 2018, HYPERTENSION, V71, P437, DOI 10.1161/HYPERTENSIONAHA.117.10529
   Lurbe E, 2014, HYPERTENSION, V63, P1326, DOI 10.1161/HYPERTENSIONAHA.114.03137
   Marchesi C, 2012, J HYPERTENS, V30, P3, DOI 10.1097/HJH.0b013e32834d249a
   Martinez-Aguayo A, 2016, J HYPERTENS, V34, P1808, DOI 10.1097/HJH.0000000000001017
   McNulty M, 2005, AM J HYPERTENS, V18, P504, DOI 10.1016/j.amjhyper.2004.11.011
   Meister TA, 2018, J AM COLL CARDIOL, V72, P1267, DOI 10.1016/j.jacc.2018.06.060
   Meyer AA, 2006, PEDIATRICS, V117, P1560, DOI 10.1542/peds.2005-2140
   Meyer AA, 2006, J AM COLL CARDIOL, V48, P1865, DOI 10.1016/j.jacc.2006.07.035
   Mitchell GF, 2004, HYPERTENSION, V43, P1239, DOI 10.1161/01.HYP.0000128420.01881.aa
   Niemirska A, 2016, J HYPERTENS, V34, P1815, DOI 10.1097/HJH.0000000000001024
   Niemirska A, 2013, HYPERTENSION, V62, P782, DOI 10.1161/HYPERTENSIONAHA.113.01292
   Nilsson PM, 2008, J HYPERTENS, V26, P1049, DOI 10.1097/HJH.0b013e3282f82c3e
   Nilsson PM, 2020, FRONT CARDIOVASC MED, V7, DOI 10.3389/fcvm.2020.00006
   Nilsson PM, 2018, J HYPERTENS, V36, P2340, DOI 10.1097/HJH.0000000000001824
   Norlander AE, 2018, J EXP MED, V215, P21, DOI 10.1084/jem.20171773
   Obrycki L, 2020, HYPERTENSION, V75, P826, DOI 10.1161/HYPERTENSIONAHA.119.14149
   Ostrihonová T, 2017, CENT EUR J PUBL HEAL, V25, P313, DOI 10.21101/cejph.a4968
   Paripovic D, 2018, SCAND J CLIN LAB INV, V78, P595, DOI 10.1080/00365513.2018.1528504
   Pejovic B, 2007, PEDIATR NEPHROL, V22, P249, DOI 10.1007/s00467-006-0311-3
   Pludowski P, 2008, HYPERTENSION, V51, P77, DOI 10.1161/HYPERTENSIONAHA.107.100602
   Pludowski P, 2009, HYPERTENSION, V54, P1234, DOI 10.1161/HYPERTENSIONAHA.109.139949
   Reusz GS, 2010, HYPERTENSION, V56, P217, DOI 10.1161/HYPERTENSIONAHA.110.152686
   Ryder JR, 2016, PEDIATR RES, V79, P49, DOI 10.1038/pr.2015.188
   Siegrist M, 2018, ATHEROSCLEROSIS, V278, P73, DOI 10.1016/j.atherosclerosis.2018.09.003
   Sinaiko AR, 2006, HYPERTENSION, V48, P730, DOI 10.1161/01.HYP.0000237863.24000.50
   Singhal A, 2007, CIRCULATION, V115, P213, DOI 10.1161/CIRCULATIONAHA.106.617811
   Sladowska-Kozlowska J, 2012, PEDIATR NEPHROL, V27, P1943, DOI 10.1007/s00467-012-2193-x
   Song PG, 2019, JAMA PEDIATR, V173, P1154, DOI 10.1001/jamapediatrics.2019.3310
   Sorof JM, 2002, J PEDIATR-US, V140, P660, DOI 10.1067/mpd.2002.125228
   Srinivasan SR, 2006, HYPERTENSION, V48, P33, DOI 10.1161/01.HYP.0000226410.11198.f4
   Stabouli S, 2015, J HYPERTENS, V33, P88, DOI 10.1097/HJH.0000000000000369
   Sun DJY, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0089696
   Sun SS., 2009, J Pediatr, V155, pe1
   Symonides B, 2010, ARCH MED SCI, V6, P689, DOI 10.5114/aoms.2010.17082
   Theodore RF, 2015, HYPERTENSION, V66, P1108, DOI 10.1161/HYPERTENSIONAHA.115.05831
   Trojanek JB, 2020, J HUM HYPERTENS, V34, P355, DOI 10.1038/s41371-019-0197-8
   Túri S, 2003, J HYPERTENS, V21, P145, DOI 10.1097/00004872-200301000-00024
   Ungvari Z, 2020, J AM COLL CARDIOL, V75, P931, DOI 10.1016/j.jacc.2019.11.061
   Urbina EM, 2019, HYPERTENSION, V74, P590, DOI 10.1161/HYPERTENSIONAHA.119.13027
   Urbina EM, 2018, J PEDIATR-US, V202, P14, DOI 10.1016/j.jpeds.2018.07.026
   Urbina EM, 2011, J CLIN HYPERTENS, V13, P332, DOI 10.1111/j.1751-7176.2011.00471.x
   van Sloten TT, 2018, HYPERTENSION, V72, P1095, DOI 10.1161/HYPERTENSIONAHA.118.11442
   Vohr BR, 2018, PEDIATRICS, V142, DOI 10.1542/peds.2018-0269
   Wang MM, 2020, J HUM HYPERTENS, V34, P319, DOI 10.1038/s41371-019-0215-x
   Warolin J, 2014, PEDIATR OBES, V9, P43, DOI 10.1111/j.2047-6310.2012.00135.x
   Werneck AO, 2016, CHILD OBES, V12, P377, DOI 10.1089/chi.2016.0042
   Woo KS, 2004, CIRCULATION, V109, P1981, DOI 10.1161/01.CIR.0000126599.47470.BE
   YAMADA Y, 1989, HYPERTENSION, V13, P870, DOI 10.1161/01.HYP.13.6.870
   Yang LL, 2020, HYPERTENSION, V75, P948, DOI 10.1161/HYPERTENSIONAHA.119.14168
   Yang L, 2018, FRONT PEDIATR, V6, DOI 10.3389/fped.2018.00333
   Yasmin, 2005, ARTERIOSCL THROM VAS, V25, P372, DOI 10.1161/01.ATV.0000151373.33830.41
   Youn JC, 2013, HYPERTENSION, V62, P126, DOI 10.1161/HYPERTENSIONAHA.113.00689
   Zhao M, 2020, J HYPERTENS, V38, P618, DOI 10.1097/HJH.0000000000002318
NR 130
TC 28
Z9 28
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD NOV
PY 2020
VL 76
IS 5
BP 1400
EP 1409
DI 10.1161/HYPERTENSIONAHA.120.14586
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA NY2RZ
UT WOS:000576244500011
PM 32981361
DA 2025-06-11
ER

PT J
AU Arozal, W
   Louisa, M
   Soetikno, V
AF Arozal, Wawaimuli
   Louisa, Melva
   Soetikno, Vivian
TI Selected Indonesian Medicinal Plants for the Management of Metabolic
   Syndrome: Molecular Basis and Recent Studies
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE curcumin; cinnamon; mangosteen; Indonesia; metabolic syndrome
ID HIGH-FAT DIET; ATTENUATES DIABETIC-NEPHROPATHY; TYROSINE-PHOSPHATASE 1B;
   GARCINIA-MANGOSTANA L.; TURMERIC CURCUMA-LONGA; NF-KAPPA-B;
   ALPHA-MANGOSTIN; INSULIN-RESISTANCE; OXIDATIVE STRESS; GUT MICROBIOTA
AB Increased prevalence of metabolic syndrome (MetS) in the world influences quality of health in all respective countries, including Indonesia. Data from Indonesian Family Life Survey reported in 2019 showed that the prevalence of MetS in Indonesia currently is 21.66%, estimated with the provincial incidence ranging up to 50%; additionally, the most common components of MetS discovered in Indonesia were poor high-density lipoprotein (HDL) cholesterol and hypertension. Management treatment of MetS involves a combination of lifestyle changes and pharmacological interventions to decrease cerebrovascular disease. Various natural substances have been shown to govern any cardiovascular or metabolic disorders through different mechanisms, such as triggering anti-inflammation, lipid profile correction, sensitization of insulin reception, or blood glucose control. In Indonesia, the utilization of natural compounds is part of the nation's culture. The community widely uses them; even though in general, their effectiveness and safety have not been thoroughly assessed by rigorous clinical trials. Scientific evidence suggested that cinnamon, mangosteen, and curcumin, as well as their derived components possess a broad spectrum of pharmacological activity. In this review, an enormous potential of cinnamon, mangosteen, and curcumin, which originated and are commonly used in Indonesia, could be treated against MetS, such as diabetes, hyperlipidemia, hypertension, and obesity. The findings suggested that cinnamon, mangosteen, curcumin and their derivatives may reflect areas of promise in the management of MetS.
C1 [Arozal, Wawaimuli; Louisa, Melva; Soetikno, Vivian] Univ Indonesia, Dept Pharmacol & Therapeut, Fac Med, Jakarta, Indonesia.
C3 University of Indonesia
RP Arozal, W (corresponding author), Univ Indonesia, Dept Pharmacol & Therapeut, Fac Med, Jakarta, Indonesia.
EM wawaimuli@gmail.com
RI Louisa, Melva/HNI-7441-2023
FU Direktorat Jendral Pendidikan Tinggi Republic Indonesia
FX We thanked Direktorat Jendral Pendidikan Tinggi Republic Indonesia for
   the funding support. This fund was received for open access publication
   fees.
CR Abdallah HM, 2016, MOLECULES, V21, DOI 10.3390/molecules21020251
   Abuzaid AS, 2016, IJPPS, V8, P1, DOI DOI 10.18311/jnr/2017/11051
   Aizat WM, 2019, PEERJ, V7, DOI 10.7717/peerj.6324
   Akbari M, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.00649
   Akilen R, 2010, DIABETIC MED, V27, P1159, DOI 10.1111/j.1464-5491.2010.03079.x
   Al-awar A, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/9051426
   An XD, 2019, BIOMED PHARMACOTHER, V118, DOI 10.1016/j.biopha.2019.109252
   Anand P, 2010, CHEM-BIOL INTERACT, V186, P72, DOI 10.1016/j.cbi.2010.03.044
   Anand P, 2007, MOL PHARMACEUT, V4, P807, DOI 10.1021/mp700113r
   Arun N, 2002, PLANT FOOD HUM NUTR, V57, P41, DOI 10.1023/A:1013106527829
   Bandara T, 2012, INT J FOOD SCI NUTR, V63, P380, DOI 10.3109/09637486.2011.627849
   Bereswill S, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015099
   Brunzell JD, 2007, NEW ENGL J MED, V357, P1009, DOI 10.1056/NEJMcp070061
   Bumrungpert A, 2010, J NUTR, V140, P842, DOI 10.3945/jn.109.120022
   Bumrungpert A, 2009, J NUTR, V139, P1185, DOI 10.3945/jn.109.106617
   Burapan S, 2017, J AGR FOOD CHEM, V65, P3306, DOI 10.1021/acs.jafc.7b00943
   Cao HP, 2007, ARCH BIOCHEM BIOPHYS, V459, P214, DOI 10.1016/j.abb.2006.12.034
   Castro AM., 2017, Revista Medica del Hospital General de Mexico, V80, P101, DOI [10.1016/j.hgmx.2016.06, DOI 10.1016/J.HGMX.2016.06]
   Chen HM, 2008, AM J KIDNEY DIS, V52, P58, DOI 10.1053/j.ajkd.2008.02.303
   Chen L, 2012, J AGR FOOD CHEM, V60, P9144, DOI 10.1021/jf3024535
   Chen LG, 2008, FOOD CHEM TOXICOL, V46, P688, DOI 10.1016/j.fct.2007.09.096
   Chitchumroonchokchai C, 2012, J NUTR, V142, P675, DOI 10.3945/jn.111.156992
   Choi YH, 2015, J AGR FOOD CHEM, V63, P8399, DOI 10.1021/acs.jafc.5b01637
   Daniel H, 2014, ISME J, V8, P295, DOI 10.1038/ismej.2013.155
   Ejaz A, 2009, J NUTR, V139, P919, DOI 10.3945/jn.108.100966
   El-Azab MF, 2011, EUR J PHARMACOL, V658, P41, DOI 10.1016/j.ejphar.2011.02.010
   El-Moselhy MA, 2011, FOOD CHEM TOXICOL, V49, P1129, DOI 10.1016/j.fct.2011.02.004
   Elfahmi, 2014, J HERB MED, V4, P51, DOI 10.1016/j.hermed.2014.01.002
   Ellulu MS, 2017, ARCH MED SCI, V13, P851, DOI 10.5114/aoms.2016.58928
   Engin A, 2017, ADV EXP MED BIOL, V960, P381, DOI 10.1007/978-3-319-48382-5_16
   Ferguson JJA, 2018, METABOLISM, V82, P22, DOI 10.1016/j.metabol.2017.12.009
   Franceschelli S, 2016, J CELL PHYSIOL, V231, P2439, DOI 10.1002/jcp.25348
   Gillum MP, 2011, DIABETES, V60, P3235, DOI 10.2337/db11-0616
   Greiner AK, 2014, AM J PHYSIOL-GASTR L, V307, pG1, DOI 10.1152/ajpgi.00044.2014
   Grundy SM, 2006, NAT REV DRUG DISCOV, V5, P294, DOI 10.1038/nrd2005
   Gruzdeva O, 2019, DIABET METAB SYND OB, V12, P191, DOI 10.2147/DMSO.S182406
   Gutierres VO, 2012, BRIT J NUTR, V108, P440, DOI 10.1017/S0007114511005769
   Gutierres VO, 2019, PHYTOTHER RES, V33, P976, DOI 10.1002/ptr.6291
   Gutierrez-Orozco F, 2015, NUTRIENTS, V7, P764, DOI 10.3390/nu7020764
   Gutierrez-Orozco F, 2013, NUTRIENTS, V5, P3163, DOI 10.3390/nu5083163
   Hadi A, 2019, PHARMACOL RES, V150, DOI 10.1016/j.phrs.2019.104505
   He Y, 2015, MOLECULES, V20, P9183, DOI 10.3390/molecules20059183
   Herningtyas EH, 2019, BMC PUBLIC HEALTH, V19, DOI 10.1186/s12889-019-6711-7
   Hodai H, 2016, END ABSTR, V43, pOC51, DOI [10.1530/endoabs.43.OC51, DOI 10.1530/ENDOABS.43.OC51]
   Inoue K, 2008, J AGR FOOD CHEM, V56, P9328, DOI 10.1021/jf801815n
   Jain SG, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0504-8
   Jain SK, 2009, ANTIOXID REDOX SIGN, V11, P241, DOI 10.1089/ars.2008.2140
   Jang EM, 2008, METABOLISM, V57, P1576, DOI 10.1016/j.metabol.2008.06.014
   Jariyapongskul A, 2018, CLIN HEMORHEOL MICRO, V69, P471, DOI 10.3233/CH-170345
   Jariyapongskul A, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/785826
   Jiang CS, 2012, ACTA PHARMACOL SIN, V33, P1217, DOI 10.1038/aps.2012.90
   Jiang J, 2017, METABOLISM, V77, P58, DOI 10.1016/j.metabol.2017.08.006
   Jin S, 2011, FOOD CHEM TOXICOL, V49, P1521, DOI 10.1016/j.fct.2011.03.043
   Kang H, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-90
   Kang QH, 2009, BRIT J PHARMACOL, V157, P1354, DOI 10.1111/j.1476-5381.2009.00261.x
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Kauppinen A, 2013, CELL SIGNAL, V25, P1939, DOI 10.1016/j.cellsig.2013.06.007
   Kaur Ginpreet, 2012, ISRN Pharmacol, V2012, P957283, DOI 10.5402/2012/957283
   Khajehdehi P, 2011, SCAND J UROL NEPHROL, V45, P365, DOI 10.3109/00365599.2011.585622
   Kim HM, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0179204
   Kudiganti V, 2016, LIPIDS HEALTH DIS, V15, DOI 10.1186/s12944-016-0306-4
   Kumar S, 2019, J PHARM PHARMACOL, V71, P1735, DOI 10.1111/jphp.13173
   Kwan HY, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-02263-5
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Lee D, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19051484
   Lenzen S, 2008, DIABETOLOGIA, V51, P216, DOI 10.1007/s00125-007-0886-7
   Lewington S, 2002, LANCET, V360, P1903, DOI 10.1016/S0140-6736(02)11911-8
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Li JM, 2010, HEPATOLOGY, V51, P1555, DOI 10.1002/hep.23524
   Li L, 2013, PLANTA MED, V79, P646, DOI 10.1055/s-0032-1328543
   Li R, 2011, FOOD CHEM, V126, P1890, DOI 10.1016/j.foodchem.2010.12.014
   Liu TT, 2018, BIOCHEM BIOPH RES CO, V496, P394, DOI 10.1016/j.bbrc.2018.01.040
   Liu YJ, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0145315
   Lopresti AL, 2018, ADV NUTR, V9, P41, DOI 10.1093/advances/nmx011
   Luo YL, 2019, BIOMED PHARMACOTHER, V118, DOI 10.1016/j.biopha.2019.109256
   Luo YL, 2017, BIOSCIENCE REP, V37, DOI [10.1042/BSR20170779, 10.1042/bsr20170779]
   Ma JL, 2010, BMC CANCER, V10, DOI 10.1186/1471-2407-10-112
   Mahabusarakam W, 2000, FREE RADICAL RES, V33, P643, DOI 10.1080/10715760000301161
   Maithilikarpagaselvi N, 2016, PHARM BIOL, V54, P2857, DOI 10.1080/13880209.2016.1187179
   Makimori RY, 2020, J MYCOL MED, V30, DOI 10.1016/j.mycmed.2020.100933
   Manaf S, 2016, DRUG DES DEV THER, V10, P1279, DOI 10.2147/DDDT.S97568
   Manna P, 2015, METAB SYNDR RELAT D, V13, P423, DOI 10.1089/met.2015.0095
   Maric-Bilkan C, 2013, MED CLIN N AM, V97, P59, DOI 10.1016/j.mcna.2012.10.010
   Markey O, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-78
   Medagama AB, 2015, NUTR J, V14, DOI 10.1186/s12937-015-0098-9
   Mekseepralard Chantana, 2015, Journal of the Medical Association of Thailand, V98, pS23
   Miyazawa T, 2018, NUTR METAB, V15, DOI 10.1186/s12986-018-0250-6
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Mousavi SM, 2020, CRIT REV FOOD SCI, V60, P3144, DOI 10.1080/10408398.2019.1678012
   Muchtaridi M., 2016, INT J PHARM PHARM SC, V8, P232
   Na LX, 2011, NUTR METAB CARDIOVAS, V21, P526, DOI 10.1016/j.numecd.2009.11.009
   Na LX, 2013, MOL NUTR FOOD RES, V57, P1569, DOI 10.1002/mnfr.201200131
   Nahar L, 2007, CURR MED CHEM, V14, P1349, DOI 10.2174/092986707780597880
   Nakmareong S, 2012, HYPERTENS RES, V35, P418, DOI 10.1038/hr.2011.180
   Nayak IMN, 2017, J CLIN DIAGN RES, V11, DOI 10.7860/JCDR/2017/23910.9864
   Neuschwander-Tetri BA, 2003, HEPATOLOGY, V37, P1202, DOI 10.1053/jhep.2003.50193
   Nishiyama T, 2005, J AGR FOOD CHEM, V53, P959, DOI 10.1021/jf0483873
   Nyadjeu Paulin, 2011, J Complement Integr Med, V8, DOI 10.2202/1553-3840.1490
   Obolskiy D, 2009, PHYTOTHER RES, V23, P1047, DOI 10.1002/ptr.2730
   Oussaada SM, 2019, METABOLISM, V92, P26, DOI 10.1016/j.metabol.2018.12.012
   Panahi Y, 2018, DRUG RES, V68, P403, DOI 10.1055/s-0044-101752
   Panahi Y, 2017, CURR CLIN PHARMACOL, V12, P253, DOI 10.2174/1574884713666180104095641
   Panchal SK, 2011, J BIOMED BIOTECHNOL, DOI 10.1155/2011/351982
   Pari L, 2007, FUND CLIN PHARMACOL, V21, P665, DOI 10.1111/j.1472-8206.2007.00542.x
   Peeyush KT, 2009, LIFE SCI, V85, P704, DOI 10.1016/j.lfs.2009.09.012
   Peng XF, 2008, J AGR FOOD CHEM, V56, P1907, DOI 10.1021/jf073065v
   Pengpid S, 2018, COMPLEMENT THER CLIN, V33, P156, DOI 10.1016/j.ctcp.2018.10.006
   Petiwala SM, 2014, NUTR RES, V34, P336, DOI 10.1016/j.nutres.2014.03.002
   Qin S, 2017, NUTR J, V16, DOI 10.1186/s12937-017-0293-y
   Qin YF, 2018, GENOME BIOL, V19, DOI 10.1186/s13059-018-1389-1
   Quan XF, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033376
   Ranasinghe P, 2012, DIABETIC MED, V29, P1480, DOI 10.1111/j.1464-5491.2012.03718.x
   RAO PV, 2014, EVID-BASED COMPL ALT, V2014, DOI DOI 10.1155/2014/642942
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Ryu HW, 2011, PHYTOCHEMISTRY, V72, P2148, DOI 10.1016/j.phytochem.2011.08.007
   Saxena T, 2018, EXPERT REV CARDIOVAS, V16, P879, DOI 10.1080/14779072.2018.1540301
   Schug TT, 2011, ANN MED, V43, P198, DOI 10.3109/07853890.2010.547211
   Sengupta K, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-122
   Seo KI, 2008, MOL NUTR FOOD RES, V52, P995, DOI 10.1002/mnfr.200700184
   Shao WJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0028784
   Shapiro H, 2005, NUTR RES REV, V18, P212, DOI 10.1079/NRR2005106
   Sharma S, 2006, CLIN EXP PHARMACOL P, V33, P940, DOI 10.1111/j.1440-1681.2006.04468.x
   Shen L, 2019, CRIT REV FOOD SCI, V59, P2896, DOI 10.1080/10408398.2018.1478388
   Shen L, 2017, FOOD NUTR RES, V61, DOI 10.1080/16546628.2017.1361780
   Shen QW, 2014, MOL NUTR FOOD RES, V58, P239, DOI 10.1002/mnfr.201300181
   Sheng XY, 2008, PPAR RES, V2008, DOI 10.1155/2008/581348
   Shibata MA, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20071722
   Shihabudeen HMS, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-46
   Siviero A, 2015, J HERB MED, V5, P57, DOI 10.1016/j.hermed.2015.03.001
   Soda M, 2012, BIOL PHARM BULL, V35, P2075, DOI 10.1248/bpb.b12-00538
   Soetikno V, 2011, MOL NUTR FOOD RES, V55, P1655, DOI 10.1002/mnfr.201100080
   Sonnenburg JL, 2016, NATURE, V535, P56, DOI 10.1038/nature18846
   Stern JS, 2013, OBESITY, V21, P921, DOI 10.1002/oby.20211
   Stocker R, 2004, PHYSIOL REV, V84, P1381, DOI 10.1152/physrev.00047.2003
   Sun LJ, 2018, PROTEIN CELL, V9, P397, DOI 10.1007/s13238-018-0546-3
   Taher M, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1118-9
   Taher M, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/740238
   Talaei B, 2017, NUTRIENTS, V9, DOI 10.3390/nu9090991
   Tang WH, 2012, FRONT PHARMACOL, V3, DOI 10.3389/fphar.2012.00087
   Tanoue T, 2010, GUT MICROBES, V1, P224, DOI 10.4161/gmic.1.4.12613
   Tep-Areenan Patcharin, 2012, J Med Assoc Thai, V95 Suppl 12, pS63
   Tikoo K, 2008, BRIT J PHARMACOL, V153, P1225, DOI 10.1038/sj.bjp.0707666
   Tsai SY, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0148-0
   Udani JK, 2009, NUTR J, V8, DOI 10.1186/1475-2891-8-48
   van Duynhoven J, 2011, P NATL ACAD SCI USA, V108, P4531, DOI 10.1073/pnas.1000098107
   Van Hul M, 2018, AM J PHYSIOL-ENDOC M, V314, pE334, DOI 10.1152/ajpendo.00107.2017
   von Rintelen K., 2017, Res Ideas Outcomes, V3, pe20860, DOI [DOI 10.3897/RIO.3.E20860, 10.3897/rio.3.e20860]
   Wang MH, 2017, CHIN J NAT MEDICINES, V15, P81, DOI 10.1016/S1875-5364(17)30024-9
   Watanabe M, 2018, NUTRIENTS, V10, DOI 10.3390/nu10050586
   Widowati W, 2018, IRAN J BASIC MED SCI, V21, P972, DOI 10.22038/IJBMS.2018.29349.7094
   Wihastuti T. A., 2015, Asian Pacific Journal of Tropical Disease, V5, P830
   Wihastuti TA, 2014, VASC HEALTH RISK MAN, V10, P523, DOI 10.2147/VHRM.S61736
   WILLIAMS P, 1995, FREE RADICAL RES, V23, P175, DOI 10.3109/10715769509064030
   Wong SK, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0123-9
   Xia J, 2016, BRAIN RES, V1642, P131, DOI 10.1016/j.brainres.2016.03.022
   Xie ZH, 2015, FOOD SCI NUTR, V3, P32, DOI 10.1002/fsn3.187
   Yao Y, 2016, SCI REP, V6, P1, DOI DOI 10.1038/srep25579
   Yin P, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-52036-5
   YU SM, 1994, BRIT J PHARMACOL, V111, P906, DOI 10.1111/j.1476-5381.1994.tb14824.x
   YUAN JH, 1993, FUND APPL TOXICOL, V20, P83, DOI 10.1006/faat.1993.1010
   Zam W, 2018, J NUTR METAB, V2018, DOI 10.1155/2018/1367984
   Zhang JH, 2012, COMPLEMENT THER MED, V20, P100, DOI 10.1016/j.ctim.2011.09.004
NR 162
TC 13
Z9 15
U1 0
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD MAY 6
PY 2020
VL 7
AR 82
DI 10.3389/fcvm.2020.00082
PG 16
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA LS8KI
UT WOS:000536629400001
PM 32435657
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hirata, A
   Kishida, K
   Nakatsuji, H
   Hiuge-Shimizu, A
   Funahashi, T
   Shimomura, I
AF Hirata, Ayumu
   Kishida, Ken
   Nakatsuji, Hideaki
   Hiuge-Shimizu, Aki
   Funahashi, Tohru
   Shimomura, Iichiro
TI High serum S100A8/A9 levels and high cardiovascular complication rate in
   type 2 diabetics with ultrasonographic low carotid plaque density
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE S100A8/A9 complex; Adiponectin; Vulnerable blood; Vulnerable plaque
ID MYELOID-RELATED PROTEIN-14; NADPH OXIDASE ACTIVATION; ACUTE CORONARY
   SYNDROMES; BIOELECTRICAL-IMPEDANCE; ATHEROSCLEROTIC PLAQUES;
   RHEUMATOID-ARTHRITIS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   ARACHIDONIC-ACID; ARTERY-DISEASE
AB Aims: S100A8/A9 complex is an inflammation-associated biomarker, which binds toll-like receptor 4 and was associated with the receptor for advanced glycation end-products. S100A8 and S100A9 were accumulated in atherosclerotic lesions. High serum levels of S100A8/A9 are associated with acute coronary syndrome and atherosclerosis in type 2 diabetes mellitus (T2DM). However, association between serum S100A8/A9 levels and vulnerable plaque remains unclear. The present study investigated the relation between serum S100A8/A9 levels and relative plaque density (RPD) of the carotid artery determined by ultrasonography in T2DM.
   Methods: The study subjects were 72 consecutive T2DM outpatients (males/females = 42/30), who underwent the carotid artery ultrasonography. RPD in the carotid artery was calculated by the formula; RPD = [density of the carotid plaque/density of vessel lumen]. Serum levels of adiponectin and S100A8/A9 were measured.
   Results: The median RPD was 2.1. Patients with low RPD (<= 2.1) were significantly more likely to have metabolic syndrome, nephropathy, coronary artery disease, and peripheral artery disease, and higher levels of S100A8/A9, S100A8/A9-to-adiponectin ratio, and uric acid, compared to those with high RPD (> 2.1).
   Conclusions: T2DM patients with low RPD had higher prevalence of metabolic syndrome, cardiovascular diseases and higher serum S100A8/A9 levels, compared to those with high RPD. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
C1 [Kishida, Ken; Funahashi, Tohru] Osaka Univ, Grad Sch Med, Dept Metab & Atherosclerosis, Suita, Osaka 5650871, Japan.
   [Hirata, Ayumu; Kishida, Ken; Nakatsuji, Hideaki; Hiuge-Shimizu, Aki; Funahashi, Tohru; Shimomura, Iichiro] Osaka Univ, Grad Sch Med, Dept Metab Med, Suita, Osaka 5650871, Japan.
C3 The University of Osaka; The University of Osaka
RP Kishida, K (corresponding author), Osaka Univ, Grad Sch Med, Dept Metab & Atherosclerosis, 2-2 B-5 Yamada Oka, Suita, Osaka 5650871, Japan.
EM kkishida@imed2.med.osaka-u.ac.jp
FU Kowa Co. Ltd.; (Research in a proposed research area) "Molecular Basis
   and Disorders of Control of Appetite and Fat Accumulation" [22126008];
   Grants-in-Aid for Scientific Research [22126008] Funding Source: KAKEN
FX The authors declare that they have no conflict of interest. Ken Kishida
   and Tohru Funahashi are members of the "Department of Metabolism and
   Atherosclerosis'', a sponsored course endowed by Kowa Co. Ltd. and a
   company researcher is dispatched to the course.We thank all staff at
   "Diabetes & Metabolic Station'' for the excellent medical care, Dr.
   Norikazu Maeda for patient enrolment, and Mrs Yoko Motomura and Miyuki
   Nakamura for the excellent technical assistance. This research was
   supported in part by a Grant-in-Aid for Scientific Research on
   Innovative Areas (Research in a proposed research area) "Molecular Basis
   and Disorders of Control of Appetite and Fat Accumulation" (#22126008,
   to T. F. and K. K., Chiyoda, Tokyo, Japan).
CR Altwegg LA, 2007, EUR HEART J, V28, P941, DOI 10.1093/eurheartj/ehm078
   Arita Y, 1999, BIOCHEM BIOPH RES CO, V257, P79, DOI 10.1006/bbrc.1999.0255
   Bouzidi F, 2004, BIOCHEM BIOPH RES CO, V325, P1060, DOI 10.1016/j.bbrc.2004.10.134
   Boyd JH, 2008, CIRC RES, V102, P1239, DOI 10.1161/CIRCRESAHA.107.167544
   Catalán V, 2011, MOL MED, V17, P1157, DOI 10.2119/molmed.2011.00144
   Croce K, 2009, CIRCULATION, V120, P427, DOI 10.1161/CIRCULATIONAHA.108.814582
   Eijgelaar WJ, 2009, THROMB HAEMOSTASIS, V102, P231, DOI 10.1160/TH09-01-0030
   Foell D, 2004, CLIN CHIM ACTA, V344, P37, DOI 10.1016/j.cccn.2004.02.023
   Frosch M, 2000, ARTHRITIS RHEUM-US, V43, P628, DOI 10.1002/1529-0131(200003)43:3<628::AID-ANR20>3.0.CO;2-X
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   HANDA N, 1990, STROKE, V21, P1567, DOI 10.1161/01.STR.21.11.1567
   Hansson GK, 2005, NEW ENGL J MED, V352, P1685, DOI 10.1056/NEJMra043430
   Healy AM, 2006, CIRCULATION, V113, P2278, DOI 10.1161/CIRCULATIONAHA.105.607333
   Heeschen C, 2003, NEW ENGL J MED, V348, P1104, DOI 10.1056/NEJMoa022600
   Hirata A, 2011, ATHEROSCLEROSIS, V219, P623, DOI 10.1016/j.atherosclerosis.2011.08.043
   Hiuge-Shimizu A, 2011, ARTERIOSCL THROM VAS, V31, P792, DOI 10.1161/ATVBAHA.110.221747
   Ionita MG, 2009, ARTERIOSCL THROM VAS, V29, P1220, DOI 10.1161/ATVBAHA.109.190314
   Kerkhoff C, 2005, FASEB J, V19, P467, DOI 10.1096/fj.04-2377fje
   Kerkhoff C, 1998, BBA-MOL CELL RES, V1448, P200, DOI 10.1016/S0167-4889(98)00144-X
   Kishida K, 2011, J ATHEROSCLER THROMB, V18, P592, DOI 10.5551/jat.7625
   Libby P, 2002, NAT MED, V8, P1257, DOI 10.1038/nm1102-1257
   Lind L, 2003, ATHEROSCLEROSIS, V169, P203, DOI 10.1016/S0021-9150(03)00012-1
   Maeda K, 1996, BIOCHEM BIOPH RES CO, V221, P286, DOI 10.1006/bbrc.1996.0587
   Matsuo S, 2009, AM J KIDNEY DIS, V53, P982, DOI 10.1053/j.ajkd.2008.12.034
   McCormick MM, 2005, J BIOL CHEM, V280, P41521, DOI 10.1074/jbc.M509442200
   Miyamoto S, 2008, HEART, V94, P1002, DOI 10.1136/hrt.2007.121640
   Morrow DA, 2008, AM HEART J, V155, P49, DOI 10.1016/j.ahj.2007.08.018
   Nacken W, 2003, MICROSC RES TECHNIQ, V60, P569, DOI 10.1002/jemt.10299
   Nakatsuji H, 2010, ATHEROSCLEROSIS, V212, P243, DOI 10.1016/j.atherosclerosis.2010.05.025
   ODINK K, 1987, NATURE, V330, P80, DOI 10.1038/330080a0
   Okauchi Y, 2010, J ATHEROSCLER THROMB, V17, P1237, DOI 10.5551/jat.5694
   Okauchi Yukiyoshi, 2009, Diabetes Care, V32, pe122, DOI 10.2337/dc09-1130
   Peng WH, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-41
   Peters SAE, 2011, J ATHEROSCLER THROMB, V18, P784, DOI 10.5551/jat.8169
   Ravasi T, 2004, GENOMICS, V84, P10, DOI 10.1016/j.ygeno.2004.02.002
   Ryo M, 2005, DIABETES CARE, V28, P451, DOI 10.2337/diacare.28.2.451
   Takemura Yukihiro, 2007, Curr Atheroscler Rep, V9, P238, DOI 10.1007/s11883-007-0025-4
   Teramoto T, 2008, J ATHEROSCLER THROMB, V15, P1, DOI 10.5551/jat.E580
   Vasan RS, 2006, CIRCULATION, V113, P2335, DOI 10.1161/CIRCULATIONAHA.104.482570
   Vogl T, 2007, NAT MED, V13, P1042, DOI 10.1038/nm1638
NR 40
TC 25
Z9 32
U1 0
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD JUL
PY 2012
VL 97
IS 1
BP 82
EP 90
DI 10.1016/j.diabres.2012.01.026
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 977JS
UT WOS:000306655500018
PM 22333479
DA 2025-06-11
ER

PT J
AU Yavorov-Dayliev, D
   Milagro, FI
   Ayo, J
   Oneca, M
   Aranaz, P
AF Yavorov-Dayliev, Deyan
   Milagro, Fermin I.
   Ayo, Josune
   Oneca, Maria
   Aranaz, Paula
TI Pediococcus acidilactici CECT9879 (pA1c) Counteracts the Effect
   of a High-Glucose Exposure in C. elegans by Affecting the Insulin
   Signaling Pathway (IIS)
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE probiotic; diabetes; obesity; Caenorhabditis elegans;
   insulin-signaling-pathway; beta-oxidation; daf-16
ID CAENORHABDITIS-ELEGANS; LIFE-SPAN; FAT ACCUMULATION; OXIDATIVE STRESS;
   GUT MICROBIOTA; OBESITY; RESVERATROL; METABOLISM; DAF-16; MODEL
AB The increasing prevalence of metabolic syndrome-related diseases, including type-2 diabetes and obesity, makes it urgent to develop new alternative therapies, such as probiotics. In this study, we have used Caenorhabditis elegans under a high-glucose condition as a model to examine the potential probiotic activities of Pediococcus acidilactici CECT9879 (pA1c). The supplementation with pA1c reduced C. elegans fat accumulation in a nematode growth medium (NGM) and in a high-glucose (10 mM) NGM medium. Moreover, treatment with pA1c counteracted the effect of the high glucose by reducing reactive oxygen species by 20%, retarding the aging process and extending the nematode median survival (> 2 days in comparison with untreated control worms). Gene expression analyses demonstrated that the probiotic metabolic syndrome-alleviating activities were mediated by modulation of the insulin/IGF-1 signaling pathway (IIS) through the reversion of the glucose-nuclear-localization of daf-16 and the overexpression of ins-6 and daf-16 mediators, increased expression of fatty acid (FA) peroxisomal beta-oxidation genes, and downregulation of FA biosynthesis key genes. Taken together, our data suggest that pA1c could be considered a potential probiotic strain for the prevention of the metabolic syndrome-related disturbances and highlight the use of C. elegans as an appropriate in vivo model for the study of the mechanisms underlying these diseases.
C1 [Yavorov-Dayliev, Deyan; Ayo, Josune; Oneca, Maria] Genbioma Aplicac SL Poligono Ind Noain Esquiroz, Calle S,Nave 4, Esquiroz 31191, Spain.
   [Yavorov-Dayliev, Deyan; Milagro, Fermin I.; Aranaz, Paula] Univ Navarra, Fac Pharm & Nutr, Ctr Nutr Res, Pamplona 31008, Spain.
   [Milagro, Fermin I.; Aranaz, Paula] Navarra Inst Hlth Res IdiSNA, Pamplona 31008, Spain.
   [Milagro, Fermin I.] Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, Madrid 28029, Spain.
C3 University of Navarra; University of Navarra; Instituto de Salud Carlos
   III; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN
RP Milagro, FI (corresponding author), Univ Navarra, Fac Pharm & Nutr, Ctr Nutr Res, Pamplona 31008, Spain.; Milagro, FI (corresponding author), Navarra Inst Hlth Res IdiSNA, Pamplona 31008, Spain.; Milagro, FI (corresponding author), Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, Madrid 28029, Spain.
EM deyan@genbioma.com; fmilagro@unav.es; josune@genbioma.com;
   maria@genbioma.com; paranaz@unav.es
RI Milagro, Fermin/F-2315-2015
OI Milagro, Fermin I./0000-0002-3228-9916; Yavorov Dayliev,
   Deyan/0000-0002-7901-0695; Ayo, Josune/0000-0002-2379-0442
FU Government of Navarra [0011-1408-2020-000010]; Genbioma Aplicaciones
   S.L.; Spanish Ministry of Science and Innovation (Ayudas para contratos
   Torres Quevedo) [PTQ2019-010384/AEI/10.13039/501100011033]; CIBERobn
   grant [CB12/03/30002]
FX This research was funded by a grant from Government of Navarra (Ayudas
   para la contratacion de doctorandos y doctorandas Doctorados
   industriales 2020) [Reference: 0011-1408-2020-000010]. This study was
   also funded by grants from Genbioma Aplicaciones S.L., M.O. is supported
   by Torres-Quevedo grants from the Spanish Ministry of Science and
   Innovation (Ayudas para contratos Torres Quevedo
   PTQ2019-010384/AEI/10.13039/501100011033). F.I.M. is supported by
   CIBERobn grant (Grant number: CB12/03/30002).
CR Abenavoli L, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112690
   Achuthan AA, 2012, MOL BIOL REP, V39, P7887, DOI 10.1007/s11033-012-1633-9
   Aranaz P, 2020, PHARMACEUTICALS-BASE, V13, DOI 10.3390/ph13110355
   Ashrafi K, 2003, NATURE, V421, P268, DOI 10.1038/nature01279
   Ayuda-Durán B, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0199483
   Ayyadevara S, 2008, AGING CELL, V7, P13, DOI 10.1111/j.1474-9726.2007.00348.x
   Balaguer F, 2022, MICROB BIOTECHNOL, V15, P805, DOI 10.1111/1751-7915.13769
   Bhattacharya S, 2013, J AGR FOOD CHEM, V61, P11033, DOI 10.1021/jf402838a
   Blackwell TK, 2015, FREE RADICAL BIO MED, V88, P290, DOI 10.1016/j.freeradbiomed.2015.06.008
   Brandstädt S, 2013, AGING-US, V5, P270, DOI 10.18632/aging.100548
   Bray GA, 2003, POSTGRAD MED, V114, P19, DOI 10.3810/pgm.2003.12.1544
   Buranasin P, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0201855
   Cabello-Olmo M, 2022, NUTRIENTS, V14, DOI 10.3390/nu14030692
   Camilleri M, 2018, METAB SYNDR RELAT D, V16, P390, DOI 10.1089/met.2018.0075
   Cerdó T, 2019, NUTRIENTS, V11, DOI 10.3390/nu11030635
   Chauhan AP, 2020, 3 BIOTECH, V10, DOI 10.1007/s13205-020-02485-x
   Chen C, 2020, MECH AGEING DEV, V187, DOI 10.1016/j.mad.2020.111215
   Chen W, 2013, J PHARM PHARMACOL, V65, P682, DOI 10.1111/jphp.12023
   Das D, 2017, MOL REPROD DEV, V84, P444, DOI 10.1002/mrd.22806
   Davis M, 2017, AM J PHYSIOL-CELL PH, V312, pC741, DOI 10.1152/ajpcell.00364.2016
   Dillin A, 2002, SCIENCE, V298, P830, DOI 10.1126/science.1074240
   Escorcia W, 2018, JOVE-J VIS EXP, DOI 10.3791/57352
   Fang EF, 2017, SCI REP-UK, V7, DOI 10.1038/srep46208
   Farias-Pereira R, 2020, CURR RES FOOD SCI, V2, P70, DOI 10.1016/j.crfs.2019.11.002
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Fischer N, 2017, J PHARM PHARMACOL, V69, P73, DOI 10.1111/jphp.12657
   Fontané L, 2018, CLIN INVEST ARTERIOS, V30, P271, DOI 10.1016/j.arteri.2018.03.004
   Franco-Juárez B, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10092359
   Franco-Juárez B, 2018, AGING-US, V10, P2657, DOI 10.18632/aging.101577
   Gérard P, 2016, CELL MOL LIFE SCI, V73, P147, DOI 10.1007/s00018-015-2061-5
   Gomes AC, 2018, GUT MICROBES, V9, P308, DOI 10.1080/19490976.2018.1465157
   Grompone G, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0052493
   Henderson ST, 2001, CURR BIOL, V11, P1975, DOI 10.1016/S0960-9822(01)00594-2
   Horikawa M, 2010, MOL CELL ENDOCRINOL, V323, P183, DOI 10.1016/j.mce.2010.03.004
   Jokinen E, 2015, MINERVA PEDIATR, V67, P25
   Kaletsky R, 2016, NATURE, V529, P92, DOI 10.1038/nature16483
   Kato M, 2018, NUTRIENTS, V10, DOI 10.3390/nu10121921
   KENYON C, 1993, NATURE, V366, P461, DOI 10.1038/366461a0
   Koch K, 2020, EUR J NUTR, V59, P137, DOI 10.1007/s00394-019-01894-w
   Koliaki C, 2019, METABOLISM, V92, P98, DOI 10.1016/j.metabol.2018.10.011
   Kwon G, 2018, CURR MICROBIOL, V75, P557, DOI 10.1007/s00284-017-1416-6
   Kwon G, 2016, SCI REP-UK, V6, DOI 10.1038/srep31713
   Lee D, 2017, CELL MOL LIFE SCI, V74, P1793, DOI 10.1007/s00018-016-2432-6
   Lee SJ, 2009, CELL METAB, V10, P379, DOI 10.1016/j.cmet.2009.10.003
   Lemieux GA, 2015, CRIT REV BIOCHEM MOL, V50, P69, DOI 10.3109/10409238.2014.959890
   Li HM, 2019, FOOD CHEM X, V1, DOI 10.1016/j.fochx.2019.100005
   Lin Y, 2020, FOOD FUNCT, V11, P730, DOI [10.1039/C9FO02095K, 10.1039/c9fo02095k]
   Ling Y, 2019, CHIN J NAT MEDICINES, V17, P892, DOI 10.1016/S1875-5364(19)30109-8
   Lu LL, 2017, J BIOSCI BIOENG, V124, P1, DOI 10.1016/j.jbiosc.2017.02.021
   Marsova M, 2020, WORLD J MICROB BIOT, V36, DOI 10.1007/s11274-020-02879-2
   Martorell P, 2016, J AGR FOOD CHEM, V64, P3462, DOI 10.1021/acs.jafc.5b05934
   Martorell P, 2012, J AGR FOOD CHEM, V60, P11071, DOI 10.1021/jf3031138
   Mazloom K, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020258
   Monteiro R, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/289645
   Mullaney BC, 2009, BBA-MOL CELL BIOL L, V1791, P474, DOI 10.1016/j.bbalip.2008.12.013
   Murphy Coleen T, 2013, WormBook, P1, DOI 10.1895/wormbook.1.164.1
   Navarro-Herrera D, 2018, FOOD FUNCT, V9, P4340, DOI [10.1039/C8FO00423D, 10.1039/c8fo00423d]
   Navarro-Herrera D, 2018, FOOD FUNCT, V9, P1621, DOI [10.1039/C7FO01625E, 10.1039/c7fo01625e]
   Niccoli T, 2012, CURR BIOL, V22, pR741, DOI 10.1016/j.cub.2012.07.024
   Ortega FB, 2016, CIRC RES, V118, P1752, DOI 10.1161/CIRCRESAHA.115.306883
   Peng HM, 2016, J AGR FOOD CHEM, V64, P5207, DOI 10.1021/acs.jafc.6b02183
   Perez CL, 2008, CELL METAB, V8, P266, DOI 10.1016/j.cmet.2008.08.007
   Mayoral LPC, 2020, INDIAN J MED RES, V151, P11, DOI 10.4103/ijmr.IJMR_1768_17
   Piché ME, 2020, CIRC RES, V126, P1477, DOI 10.1161/CIRCRESAHA.120.316101
   Qi WB, 2017, AGING CELL, V16, P1125, DOI 10.1111/acel.12651
   Roselli M, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20205020
   Saad MJA, 2016, PHYSIOLOGY, V31, P283, DOI 10.1152/physiol.00041.2015
   Scott BA, 2002, SCIENCE, V296, P2388, DOI 10.1126/science.1072302
   Seo K, 2013, AGING CELL, V12, P1073, DOI 10.1111/acel.12140
   Shaikhulova S, 2021, SCI TOTAL ENVIRON, V761, DOI 10.1016/j.scitotenv.2020.143209
   Shanmugam G, 2017, BIOMED PHARMACOTHER, V95, P1693, DOI 10.1016/j.biopha.2017.09.096
   Shen PY, 2019, FOOD RES INT, V120, P157, DOI 10.1016/j.foodres.2019.02.036
   Shen PY, 2018, ANNU REV FOOD SCI T, V9, P1, DOI 10.1146/annurev-food-030117-012709
   Shen PY, 2017, J MED FOOD, V20, P887, DOI 10.1089/jmf.2016.0179
   Shen PY, 2018, CRIT REV FOOD SCI, V58, P741, DOI 10.1080/10408398.2016.1220914
   Sies H, 2017, ANNU REV BIOCHEM, V86, P715, DOI 10.1146/annurev-biochem-061516-045037
   Silva A, 2020, FOODS, V9, DOI 10.3390/foods9050652
   Sugawara T, 2018, BRIT J NUTR, V120, P872, DOI 10.1017/S0007114518001563
   Tanaka T, 1996, LIPIDS, V31, P1173, DOI 10.1007/BF02524292
   Taubert S, 2006, GENE DEV, V20, P1137, DOI 10.1101/gad.1395406
   Thompson WG, 2007, MAYO CLIN PROC, V82, P93
   Tissenbaum HA, 2018, CURR TOP DEV BIOL, V127, P1, DOI 10.1016/bs.ctdb.2017.11.007
   Tosato M, 2007, CLIN INTERV AGING, V2, P401
   Wang HL, 2018, FOOD FUNCT, V9, P5273, DOI [10.1039/c8fo01680a, 10.1039/C8FO01680A]
   Watts JL, 2017, GENETICS, V207, P413, DOI 10.1534/genetics.117.300106
   Watts JL, 2002, P NATL ACAD SCI USA, V99, P5854, DOI 10.1073/pnas.092064799
   Weimer S, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4563
   Ye K, 2010, J RADIAT RES, V51, P473, DOI 10.1269/jrr.10009
   Yue YR, 2021, CURR RES FOOD SCI, V4, P551, DOI 10.1016/j.crfs.2021.08.005
   Yue YR, 2019, FOOD FUNCT, V10, P4966, DOI 10.1039/c9fo00778d
   Zecic A, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9010109
   Zheng J, 2012, INT J OBESITY, V36, P186, DOI 10.1038/ijo.2011.93
   Zia A, 2021, BIOMED PHARMACOTHER, V134, DOI 10.1016/j.biopha.2020.111119
NR 93
TC 18
Z9 18
U1 9
U2 67
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2022
VL 23
IS 5
AR 2689
DI 10.3390/ijms23052689
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA ZY9YK
UT WOS:000772934400001
PM 35269839
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lopez-Legarrea, P
   de la Iglesia, R
   Abete, I
   Navas-Carretero, S
   Martinez, JA
   Zulet, MA
AF Lopez-Legarrea, Patricia
   de la Iglesia, Rocio
   Abete, Itziar
   Navas-Carretero, Santiago
   Alfredo Martinez, J.
   Angeles Zulet, M.
TI The protein type within a hypocaloric diet affects obesity-related
   inflammation: The RESMENA project
SO NUTRITION
LA English
DT Article
DE Cardiovascular diseases; Inflammation markers; Macronutrient
   distribution; Weight loss; Metabolic syndrome
ID C-REACTIVE PROTEIN; WEIGHT-LOSS; ADIPOSE-TISSUE; POSTMENOPAUSAL WOMEN;
   ENDOTHELIAL FUNCTION; METABOLIC SYNDROME; OXIDATIVE STRESS; GLYCEMIC
   INDEX; FATTY-ACIDS; MEAT INTAKE
AB Objectives: The aim of this study was to compare the effect of two energy-restricted, differing with regard to protein content, on the inflammation state of obese individuals with features of metabolic syndrome.
   Methods: Ninety-six participants completed an 8-wk randomized intervention trial that compared the RESMENA diet (-30% energy, with 30% energy from protein) with a control diet (-30% energy, with 15% energy from protein) that was based on American Heart Association criteria.
   Results: The mean body weight losses were 7.09 +/- 0.82 kg and 6.73 +/- 0.71 kg, respectively, with no differences seen between the groups. The endpoint inflammation score which was based on high-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-alpha, and plasminogen activator inhibitor-1 levels was significantly lower (P = 0.012) in the low-protein group (6.81 +/- 232 versus 7.94 +/- 1.94). The linear regression analyses revealed that total protein intake was positively associated with inflammation (P = 0.007) as well as with animal protein (P = 0.025) and meat protein (P = 0.015), but neither vegetable- nor fish-derived proteins were found to influence inflammatory status.
   Conclusions: Our results suggest that the type of protein consumed (more than the total protein consumed) within an energy-restricted diet influences the inflammation status associated with obesity-related comorbidities. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Lopez-Legarrea, Patricia; de la Iglesia, Rocio; Navas-Carretero, Santiago; Alfredo Martinez, J.; Angeles Zulet, M.] Univ Navarra, Dept Nutr Food Sci & Physiol, E-31080 Pamplona, Spain.
   [Abete, Itziar] Biodonostia Hlth Res Inst, San Sebastian, Spain.
   [Abete, Itziar; Navas-Carretero, Santiago; Alfredo Martinez, J.; Angeles Zulet, M.] CIBERobn, Carlos Hlth Inst 3, Madrid, Spain.
C3 University of Navarra; Instituto de Investigacion Sanitaria Biogipuzkoa;
   CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN
RP Martinez, JA (corresponding author), Univ Navarra, Dept Nutr Food Sci & Physiol, E-31080 Pamplona, Spain.
EM jalfmtz@unav.es
RI de la Iglesia, Rocio/ABC-6189-2020; Abete, Itziar/H-4827-2017; Martinez
   Hernandez, J Alfredo/K-8709-2014; Navas-Carretero, Santiago/L-2918-2015;
   Zulet, M. Angeles/H-1317-2017
OI Abete, Itziar/0000-0002-6475-5387; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941; Navas-Carretero,
   Santiago/0000-0002-5163-2230; de la Iglesia, Rocio/0000-0002-7472-3565;
   Zulet, M. Angeles/0000-0002-3926-0892
FU Health Department of the Government of Navarra [48/2009]; Linea Especial
   about Nutrition, Obesity and Health (University of Navarra) [LE/97];
   CIBERobn; RETICS; Government of Navarra [233/2009]
FX This work was supported by the Health Department of the Government of
   Navarra (48/2009), the Linea Especial about Nutrition, Obesity and
   Health (University of Navarra LE/97), and CIBERobn and RETICS. The
   Government of Navarra provided a predoctoral research grant to Patricia
   Lopez-Legarrea (Predoctoral no. 233/2009). We acknowledge the
   volunteers, the physician Blanca Martinez de Morentin, the nurse Salome
   Perez, and the technician Veronica Ciaurriz for their excellent
   technical assistance.
CR Abete I, 2011, NUTR METAB CARDIOVAS, V21, pB1, DOI 10.1016/j.numecd.2011.05.001
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   [Anonymous], J AM DIET ASS
   Asemi Z, 2013, NUTRITION, V29, P619, DOI 10.1016/j.nut.2012.11.020
   Azadbakht L, 2007, BRIT J NUTR, V98, P807, DOI 10.1017/S0007114507746871
   Azadbakht L, 2007, DIABETES CARE, V30, P967, DOI 10.2337/dc06-2126
   Azadbakht L, 2009, J NUTR, V139, P335, DOI 10.3945/jn.108.096297
   Baumgartner S, 2013, NUTRITION, V29, P1237, DOI 10.1016/j.nut.2013.03.020
   Belalcazar LM, 2011, ARTERIOSCL THROM VAS, V31, P1689, DOI 10.1161/ATVBAHA.111.224386
   Benatar JR, 2011, EUR J CARDIOV PREV R, V18, P615, DOI 10.1177/1741826710389415
   Bhupathiraju SN, 2011, J NUTR, V141, P460, DOI 10.3945/jn.110.133603
   Bondia-Pons I, 2012, J PHYSIOL BIOCHEM, V68, P701, DOI 10.1007/s13105-012-0154-2
   Clark ML, 2013, NUTRITION, V29, P1304, DOI 10.1016/j.nut.2013.04.003
   Clément K, 2004, FASEB J, V18, P1657, DOI 10.1096/fj.04-2204com
   Clifton PM, 2009, NUTR METAB CARDIOVAS, V19, P548, DOI 10.1016/j.numecd.2008.10.006
   de la Iglesia R., 2013, BR J NUTR, V23, P1
   de Mello VDF, 2011, DIABETOLOGIA, V54, P2755, DOI 10.1007/s00125-011-2285-3
   DeBoer Mark D, 2013, Nutrition, V29, P379, DOI 10.1016/j.nut.2012.07.003
   Fernández-Real JM, 2002, DIABETES, V51, P2348, DOI 10.2337/diabetes.51.8.2348
   Gögebakan Ö, 2011, CIRCULATION, V124, P2829, DOI 10.1161/CIRCULATIONAHA.111.033274
   Golan R, 2012, NUTRITION, V28, P131, DOI 10.1016/j.nut.2011.04.001
   Guebre-Egziabher F, 2013, NUTRITION, V29, P730, DOI 10.1016/j.nut.2012.10.011
   Hermsdorff HHM, 2011, EUR J NUTR, V50, P61, DOI 10.1007/s00394-010-0115-x
   Jebb SA, 2011, LANCET, V378, P1485, DOI 10.1016/S0140-6736(11)61344-5
   Kolb H, 2010, DIABETOLOGIA, V53, P10, DOI 10.1007/s00125-009-1573-7
   Larsen Thomas Meinert, 2010, N Engl J Med, V363, P2102, DOI 10.1056/NEJMoa1007137
   Lopez-Legarrea P, 2013, NUTR METAB, V10, DOI 10.1186/1743-7075-10-22
   Hermsdorff HHM, 2009, NUTRITION, V25, P392, DOI 10.1016/j.nut.2008.09.015
   Montonen J, 2013, EUR J NUTR, V52, P337, DOI 10.1007/s00394-012-0340-6
   Murphy KJ, 2012, NUTRIENTS, V4, P711, DOI 10.3390/nu4070711
   Peppa M, 2002, DIABETES CARE, V25, P1898, DOI 10.2337/diacare.25.10.1898
   Richard C, 2013, OBESITY, V21, P51, DOI 10.1002/oby.20239
   Salehi-Abargouei A, 2013, NUTRITION, V29, P611, DOI 10.1016/j.nut.2012.12.018
   Santesso N, 2012, EUR J CLIN NUTR, V66, P780, DOI 10.1038/ejcn.2012.37
   Santos S, 2013, NUTRITION, V29, P892, DOI 10.1016/j.nut.2013.01.009
   Turner L, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.MR000030.pub2
   Uribarri J, 2005, ANN NY ACAD SCI, V1043, P461, DOI 10.1196/annals.1333.052
   Vlassara H, 2002, P NATL ACAD SCI USA, V99, P15596, DOI 10.1073/pnas.242407999
   Westerterp-Plantenga MS, 2012, BRIT J NUTR, V108, pS105, DOI 10.1017/S0007114512002589
   Wijnstok NJ, 2010, J ADOLESCENT HEALTH, V47, P346, DOI 10.1016/j.jadohealth.2010.04.008
   Wycherley TP, 2012, AM J CLIN NUTR, V96, P1281, DOI 10.3945/ajcn.112.044321
   Zulet MA, 2011, NUTR HOSP, V26, P16, DOI 10.3305/nh.2011.26.1.5050
NR 42
TC 55
Z9 61
U1 0
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD APR
PY 2014
VL 30
IS 4
BP 424
EP 429
DI 10.1016/j.nut.2013.09.009
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AD8UZ
UT WOS:000333542500009
PM 24607301
DA 2025-06-11
ER

PT J
AU Jialal, I
   Devaraj, S
   Singh, U
   Huet, BA
AF Jialal, I.
   Devaraj, S.
   Singh, U.
   Huet, B. A.
TI Decreased number and impaired functionality of endothelial progenitor
   cells in subjects with metabolic syndrome: Implications for increased
   cardiovascular risk
SO ATHEROSCLEROSIS
LA English
DT Article
DE CD34+KDR+ cells; EPC functions; CRP; Metabolic Syndrome
ID CORONARY-ARTERY-DISEASE; C-REACTIVE PROTEIN; VASCULAR COMPLICATIONS;
   OXIDATIVE STRESS; DYSFUNCTION; INFLAMMATION; HYPERTENSION; MOBILIZATION;
   ASSOCIATION; PREVALENCE
AB Objective: Metabolic syndrome (MetS) is characterized by low-grade inflammation and confers an increased risk for cardiovascular disease. Endothelial progenitor cells (EPCs) are a measure of vascular health and are decreased in patients with various risk factors for cardiovascular disease (CVD). There is a paucity of data examining the EPC status especially in terms of their functionality in MetS subjects without diabetes or cardiovascular disease. We aimed to enumerate and functionally characterize EPCs in subjects with MetS in comparison to healthy controls.
   Methods: The study was performed at the University of California Davis Medical Center. Healthy controls (n = 31) and MetS (n = 46) subjects were included in the study. EPCs were enumerated in fasting blood by KDR/CD34 dual positivity. Functionality was assessed by the colony forming units (CFU) assay, migration and tubule formation.
   Results: Subjects with MetS had significantly decreased number of EPCs compared to control subjects. Furthermore, EPCs from MetS subjects depicted significantly impaired clonogenic capacity, i.e., decreased colony forming units, and impaired capacity to incorporate into tubular structures suggesting functional impairment of EPCs from MetS subjects.
   Conclusions: We make the novel observation that MetS subjects without diabetes or CVD have decreased EPC number and impaired functionality as compared to control subjects. These. findings could contribute to the increased CV risk in this population. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
C1 [Jialal, I.] UC Davis Med Ctr, Lab Atherosclerosis & Metab Res, Dept Med Pathol & Lab Med, Sacramento, CA 95817 USA.
   VA Med Ctr, Mather, CA USA.
C3 University of California System; University of California Davis
RP Jialal, I (corresponding author), UC Davis Med Ctr, Lab Atherosclerosis & Metab Res, Dept Med Pathol & Lab Med, 4635,2nd Ave,Room 3000,Res Bldg 1, Sacramento, CA 95817 USA.
EM ijialal@ucdavis.edu
RI Jialal, Ishwarlal/AAG-6218-2019
FU ADA; NIH [K24 (AT00596)]; National Center for Research Resources(NCRR),
   National Institutes of Health (NIH) [UL1 RR024146]
FX The study was supported by ADA grant (IJ) and NIH K24 (AT00596, IJ) and
   UL1 RR024146 from the National Center for Research Resources(NCRR), a
   component of the National Institutes of Health (NIH), and to CTSC.
   Authors acknowledge assistance of Long Wang, PhD in assisting with
   subject recruitment and Manpreet Kaur for editorial assistance.
CR Alexander CM, 2003, DIABETES, V52, P1210, DOI 10.2337/diabetes.52.5.1210
   Asahara T, 1997, SCIENCE, V275, P964, DOI 10.1126/science.275.5302.964
   Bauersachs J, 2007, EUR J CLIN INVEST, V37, P603, DOI 10.1111/j.1365-2362.2007.01833.x
   Chen JZ, 2004, CLIN SCI, V107, P273, DOI 10.1042/CS20030389
   Fadini GP, 2005, CURR DIABETES REV, V1, P41, DOI 10.2174/1573399052952640
   Fadini GP, 2008, ATHEROSCLEROSIS, V197, P496, DOI 10.1016/j.atherosclerosis.2007.12.039
   Fadini GP, 2006, ARTERIOSCL THROM VAS, V26, P2140, DOI 10.1161/01.ATV.0000237750.44469.88
   Fadini GP, 2006, EUR HEART J, V27, P2247, DOI 10.1093/eurheartj/ehl198
   Fadini GP, 2009, ATHEROSCLEROSIS, V207, P213, DOI 10.1016/j.atherosclerosis.2009.03.040
   Fadini GP, 2009, METAB SYNDR RELAT D, V7, P5, DOI 10.1089/met.2008.0067
   Fadini GP, 2005, J AM COLL CARDIOL, V45, P1449, DOI 10.1016/j.jacc.2004.11.067
   Ford ES, 2005, DIABETES CARE, V28, P2745, DOI 10.2337/diacare.28.11.2745
   George J, 2004, EUR HEART J, V25, P1003, DOI 10.1016/j.ehj.2004.03.026
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hein TW, 2009, ATHEROSCLEROSIS, V206, P61, DOI 10.1016/j.atherosclerosis.2009.02.002
   Hill JM, 2003, NEW ENGL J MED, V348, P593, DOI 10.1056/NEJMoa022287
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Loomans CJM, 2004, DIABETES, V53, P195, DOI 10.2337/diabetes.53.1.195
   MacEneaney OJ, 2009, INT J OBESITY, V33, P219, DOI 10.1038/ijo.2008.262
   Müller-Ehmsen J, 2008, EUR HEART J, V29, P1560, DOI 10.1093/eurheartj/ehn213
   Satoh M, 2008, ATHEROSCLEROSIS, V198, P347, DOI 10.1016/j.atherosclerosis.2007.09.040
   Schmidt-Lucke C, 2005, CIRCULATION, V111, P2981, DOI 10.1161/CIRCULATIONAHA.104.504340
   Tepper OM, 2002, CIRCULATION, V106, P2781, DOI 10.1161/01.CIR.0000039526.42991.93
   Tousoulis D, 2008, ATHEROSCLEROSIS, V201, P236, DOI 10.1016/j.atherosclerosis.2008.05.034
   Urbich C, 2005, KIDNEY INT, V67, P1672, DOI 10.1111/j.1523-1755.2005.00261.x
   Vasa M, 2001, CIRC RES, V89, pE1, DOI 10.1161/hh1301.093953
   Verma S, 2004, CIRCULATION, V109, P2058, DOI 10.1161/01.CIR.0000127577.63323.24
   Walter DH, 2002, CIRCULATION, V105, P3017, DOI 10.1161/01.CIR.0000018166.84319.55
   Watson T, 2008, ANTIOXID REDOX SIGN, V10, P1079, DOI 10.1089/ars.2007.1998
   Werner C, 2007, DIABETES, V56, P2609, DOI 10.2337/db07-0069
   Werner N, 2005, NEW ENGL J MED, V353, P999, DOI 10.1056/NEJMoa043814
   Westerweel PE, 2008, EUR HEART J, V29, P2808, DOI 10.1093/eurheartj/ehn431
   Yu Y, 2008, AM J HYPERTENS, V21, P72, DOI 10.1038/ajh.2007.5
NR 33
TC 92
Z9 99
U1 0
U2 3
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD JUL
PY 2010
VL 211
IS 1
BP 297
EP 302
DI 10.1016/j.atherosclerosis.2010.01.036
PG 6
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 620VV
UT WOS:000279530000054
PM 20171637
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Dai, YQ
   Duan, SY
   Wang, R
   He, P
   Zhang, ZY
   Li, MY
   Shen, ZH
   Chen, Y
   Zhao, Y
   Yang, HF
   Li, XY
   Zhang, R
   Sun, J
AF Dai, Yuqing
   Duan, Siyu
   Wang, Rui
   He, Pei
   Zhang, Zhongyuan
   Li, Meiyan
   Shen, Zhuoheng
   Chen, Yue
   Zhao, Yi
   Yang, Huifang
   Li, Xiaoyu
   Zhang, Rui
   Sun, Jian
TI Associations between multiple urinary metals and metabolic syndrome:
   Exploring the mediating role of liver function in Chinese
   community-dwelling elderly
SO JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
LA English
DT Article
DE Metabolic syndrome; Urinary metals; Liver function; Community-dwelling
   elderly; Mediation
ID OXIDATIVE STRESS; HEAVY-METALS; HUMAN HEALTH; RISK-FACTOR; TOXICITY;
   ZINC; COPPER; TELLURIUM; EXPOSURE
AB Background: Multiple metals exposure has been revealed to be related to metabolic syndrome (MetS). However, the associations and interactions between multiple metals exposure and MetS are remains controversial, and the potential mechanism of the above-mentioned is still unclear. Methods: The associations between urinary metals and the MetS were analyzed by multivariable logistic regression model and restricted cubic spline (RCS). Bayesian kernel machine regression (BKMR) model and quantile-based g-computation (qgcomp) were applied to explore the mixed exposure and interaction effect of metals. Mediation analysis was used to explore the role of liver function. Results: In the single metal model, multiple metals were significantly associated with MetS. RCS analysis further verified the associations between 8 metals and MetS. BKMR model and qgcomp showed that zinc (Zn), iron (Fe), and tellurium (Te) were the main factors affecting the overall effect. In addition, mediation analysis indicated that serum alanine aminotransferase (ALT) mediated 21.54% and 13.29% in the associations of vanadium (V) and Zn with the risk of MetS, respectively. Conclusions: Elevated urinary concentration of Zn, V, Te, copper (Cu), molybdenum (Mo), and thallium (Tl) were related to the increased risk of MetS. Conversely, Fe and selenium (Se) may be protective factors for MetS in mixed exposure. Liver function may play a key role in the association of V and Zn exposure with MetS.
C1 [Dai, Yuqing; Duan, Siyu; Wang, Rui; He, Pei; Zhang, Zhongyuan; Li, Meiyan; Shen, Zhuoheng; Chen, Yue; Zhao, Yi; Yang, Huifang; Li, Xiaoyu; Zhang, Rui; Sun, Jian] Ningxia Med Univ, Sch Publ Hlth, Yinchuan 750004, Ningxia, Peoples R China.
   [Zhao, Yi] Ningxia Med Univ, NHC Key Lab Metab Cardiovasc Dis Res, Yinchuan 750004, Ningxia, Peoples R China.
   [Dai, Yuqing; Duan, Siyu; Wang, Rui; He, Pei; Zhang, Zhongyuan; Li, Meiyan; Shen, Zhuoheng; Chen, Yue; Zhao, Yi; Yang, Huifang; Li, Xiaoyu; Sun, Jian] Key Lab Environm Factors & Chron Dis Control, Yinchuan 750004, Ningxia, Peoples R China.
   [Zhang, Rui] Ningxia Med Univ, Ningxia Key Lab Cerebrocranial Dis, Incubat Base Natl Key Lab, Yinchuan 750004, Ningxia, Peoples R China.
   [Li, Xiaoyu; Zhang, Rui; Sun, Jian] 1160 Shengli St, Yinchuan 750004, Peoples R China.
C3 Ningxia Medical University; Ningxia Medical University; Ningxia Medical
   University
RP Li, XY; Zhang, R; Sun, J (corresponding author), 1160 Shengli St, Yinchuan 750004, Peoples R China.
EM lxyandpp@foxmail.com; z_zhangrui@163.com; 20180016@nxmu.edu.cn
RI Dai, Yuqing/AAC-1565-2022
FU Light of the West Talent Training Plan Project of Chinese Academy of
   Sciences [XAB2022YW18]; National Natural Science Foundation of China
   [82202431]; Natural Science Foundation Project of Ningxia, China
   [2022AAC05024, 2023AAC02032, 2022AAC05028]; Key Research and Development
   Project of Ningxia [2021BEG02026, 2023BEG02028]
FX This work was supported by the "Light of the West" Talent Training Plan
   Project of Chinese Academy of Sciences (XAB2022YW18) , the National
   Natural Science Foundation of China (No.82202431) , the Natural Science
   Foundation Project of Ningxia, China (2022AAC05024, 2023AAC02032 and
   2022AAC05028) , the Key Research and Development Project of Ningxia
   (2021BEG02026) , and the Key Research and Development Project of Ningxia
   (Grant No. 2023BEG02028) .
CR Adams LA, 2009, AM J GASTROENTEROL, V104, P861, DOI 10.1038/ajg.2009.67
   Ahn BI, 2014, BIOL TRACE ELEM RES, V160, P169, DOI 10.1007/s12011-014-0045-1
   Aigner E, 2014, NUTRIENTS, V6, P3587, DOI 10.3390/nu6093587
   Ali N, 2023, EXPERT REV ENDOCRINO, V18, P541, DOI 10.1080/17446651.2023.2272867
   Bai CH, 2017, ASIA PAC J CLIN NUTR, V26, P78, DOI 10.6133/apjcn.102015.09
   Bobb JF, 2018, ENVIRON HEALTH-GLOB, V17, DOI 10.1186/s12940-018-0413-y
   Bovolini A, 2021, INT J SPORTS MED, V42, P199, DOI 10.1055/a-1263-0898
   Breen R, 2013, SOCIOL METHOD RES, V42, P164, DOI 10.1177/0049124113494572
   Brewer GJ, 2010, CHEM RES TOXICOL, V23, P319, DOI 10.1021/tx900338d
   Britton RS, 1996, SEMIN LIVER DIS, V16, P3, DOI 10.1055/s-2007-1007214
   Cho JY, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0231485
   Chowdhury S, 2016, SCI TOTAL ENVIRON, V569, P476, DOI 10.1016/j.scitotenv.2016.06.166
   Cvjetko P, 2010, ARH HIG RADA TOKSIKO, V61, P111, DOI 10.2478/10004-1254-61-2010-1976
   Elizondo-Montemayor L, 2014, OBES RES CLIN PRACT, V8, pE79, DOI 10.1016/j.orcp.2012.08.191
   Fang CC, 2019, J TRACE ELEM MED BIO, V52, P209, DOI 10.1016/j.jtemb.2018.12.017
   Feng XM, 2021, BIOL TRACE ELEM RES, V199, P2444, DOI 10.1007/s12011-020-02371-w
   Gruzewska K, 2014, J PHYSIOL PHARMACOL, V65, P603
   Han X, 2024, ECOTOX ENVIRON SAFE, V276, DOI 10.1016/j.ecoenv.2024.116283
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Hu JW, 2021, BIOL TRACE ELEM RES, V199, P2077, DOI 10.1007/s12011-020-02318-1
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Huang SL, 2022, ECOTOX ENVIRON SAFE, V231, DOI 10.1016/j.ecoenv.2022.113183
   Jomova K, 2022, CHEM-BIOL INTERACT, V367, DOI 10.1016/j.cbi.2022.110173
   Kalantzi I, 2016, FOOD CHEM, V194, P659, DOI 10.1016/j.foodchem.2015.08.072
   Kilani N, 2015, NUTR METAB CARDIOVAS, V25, P1025, DOI 10.1016/j.numecd.2015.07.005
   Larner AJ, 1996, MED HYPOTHESES, V47, P73, DOI 10.1016/S0306-9877(96)90440-5
   Li B, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124544
   Li R, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-2870-y
   Li XQ, 2022, NUTRIENTS, V14, DOI 10.3390/nu14071415
   Liu J, 2012, BIOL TRACE ELEM RES, V145, P189, DOI 10.1007/s12011-011-9185-8
   Liu L, 2022, CHEMOSPHERE, V287, DOI 10.1016/j.chemosphere.2021.132295
   Lo K, 2021, SCI TOTAL ENVIRON, V780, DOI 10.1016/j.scitotenv.2021.146527
   Lu CW, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020548
   Ma JX, 2020, ENVIRON INT, V140, DOI 10.1016/j.envint.2020.105802
   Mojadadi A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13093256
   Olechnowicz J, 2018, J PHYSIOL SCI, V68, P19, DOI 10.1007/s12576-017-0571-7
   Patel DA, 2007, METABOLISM, V56, P792, DOI 10.1016/j.metabol.2007.01.010
   Peana M, 2021, CURR MED CHEM, V28, P7190, DOI 10.2174/0929867328666210324161205
   Pessoa JC, 2015, COORDIN CHEM REV, V301, P24, DOI 10.1016/j.ccr.2014.12.002
   Planchart A, 2018, CURR ENV HLTH REP, V5, P110, DOI 10.1007/s40572-018-0182-3
   Qu RG, 2018, NUTRIENTS, V10, DOI 10.3390/nu10080991
   Ramírez-López G, 2018, J PEDIATR ENDOCR MET, V31, P407, DOI 10.1515/jpem-2017-0217
   Renu K, 2021, CHEMOSPHERE, V271, DOI 10.1016/j.chemosphere.2021.129735
   Roohani N, 2013, J RES MED SCI, V18, P144
   Rotter I, 2015, INT J ENV RES PUB HE, V12, P3944, DOI 10.3390/ijerph120403944
   Rusu IG, 2020, NUTRIENTS, V12, DOI 10.3390/nu12071993
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sharma V, 2012, MUTAT RES-GEN TOX EN, V745, P84, DOI 10.1016/j.mrgentox.2011.12.009
   Shen ZH, 2023, ECOTOX ENVIRON SAFE, V259, DOI 10.1016/j.ecoenv.2023.114966
   Stern BR, 2007, J TOXICOL ENV HEAL B, V10, P157, DOI 10.1080/10937400600755911
   Vávrová S, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22115924
   Wang M, 2025, BIOL TRACE ELEM RES, V203, P39, DOI 10.1007/s12011-024-04152-1
   Wen WL, 2020, NUTRIENTS, V12, DOI 10.3390/nu12092666
   Yang Y, 2023, CARDIOVASC TOXICOL, V23, P388, DOI 10.1007/s12012-023-09811-8
   Yarema MC, 2005, PEDIATRICS, V116, pE319, DOI 10.1542/peds.2005-0172
   Zhu ZN, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030659
   Zwolak I, 2012, CELL BIOL TOXICOL, V28, P31, DOI 10.1007/s10565-011-9203-9
NR 57
TC 1
Z9 1
U1 5
U2 12
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0946-672X
EI 1878-3252
J9 J TRACE ELEM MED BIO
JI J. Trace Elem. Med. Biol.
PD SEP
PY 2024
VL 85
AR 127472
DI 10.1016/j.jtemb.2024.127472
EA MAY 2024
PG 10
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA UO6U6
UT WOS:001249047000001
PM 38823271
DA 2025-06-11
ER

PT J
AU Marycz, K
   Kornicka, K
   Marezdziak, M
   Golonka, P
   Nicpon, J
AF Marycz, Krzysztof
   Kornicka, Katarzyna
   Marezdziak, Monika
   Golonka, Pawel
   Nicpon, Jakub
TI Equine metabolic syndrome impairs adipose stem cells osteogenic
   differentiation by predominance of autophagy over selective mitophagy
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Article
DE mitochondria; autophagy; mitophagy; mitochondria biogenesis; equine
   metabolic syndrome; adipose derived stem cells
ID INSULIN-RESISTANCE; MULTILINEAGE DIFFERENTIATION; MITOCHONDRIAL
   BIOGENESIS; DIABETES-MELLITUS; DNA METHYLATION; UMBILICAL-CORD;
   IN-VITRO; HORSES; MICROVESICLES; EXPRESSION
AB Adipose-derived mesenchymal stem cells (ASC) hold great promise in the treatment of many disorders including musculoskeletal system, cardiovascular and/or endocrine diseases. However, the cytophysiological condition of cells, used for engraftment seems to be fundamental factor that might determine the effectiveness of clinical therapy. In this study we investigated growth kinetics, senescence, accumulation of oxidative stress factors, mitochondrial biogenesis, autophagy and osteogenic differentiation potential of ASC isolated from horses suffered from equine metabolic syndrome (EMS). We demonstrated that EMS condition impairs multipotency/pluripotency in ASCs causes accumulation of reactive oxygen species and mitochondria deterioration. We found that, cytochrome c is released from mitochondria to the cytoplasm suggesting activation of intrinsic apoptotic pathway in those cells. Moreover, we observed up-regulation of p21 and decreased ratio of Bcl-2/BAX. Deteriorations in mitochondria structure caused alternations in osteogenic differentiation of ASC(EMS) resulting in their decreased proliferation rate and reduced expression of osteogenic markers BMP-2 and collagen type I. During osteogenic differentiation of ASC(EMS), we observed autophagic turnover as probably, an alternative way to generate adenosine triphosphate and amino acids required to increased protein synthesis during differentiation. Downregulation of PGC1 alpha, PARKIN and PDK4 in differentiated ASC(EMS) confirmed impairments in mitochondrial biogenesis and function. Hence, application of ASC(EMS) into endocrinological or ortophedical practice requires further investigation and analysis in the context of safeness of their application.
C1 [Marycz, Krzysztof; Kornicka, Katarzyna] Univ Environm & Life Sci Wroclaw, Fac Biol & Anim Sci, Electron Microscopy Lab, Wroclaw, Poland.
   [Marycz, Krzysztof; Kornicka, Katarzyna] Wroclaw Res Ctr EIT, Wroclaw, Poland.
   [Marezdziak, Monika] Univ Environm & Life Sci Wroclaw, Fac Vet Med, Dept Anim Physiol & Biostruct, Wroclaw, Poland.
   [Golonka, Pawel] Equine Clin Equivet, Gliwice, Poland.
   [Nicpon, Jakub] Univ Environm & Life Sci Wroclaw, Dept Surg, Fac Vet Med, Wroclaw, Poland.
C3 Wroclaw University of Environmental & Life Sciences; Wroclaw University
   of Environmental & Life Sciences; Wroclaw University of Environmental &
   Life Sciences
RP Marycz, K (corresponding author), Univ Environm & Life Sci Wroclaw, Fac Biol & Anim Sci, Electron Microscopy Lab, Wroclaw, Poland.; Marycz, K (corresponding author), Wroclaw Res Ctr EIT, Wroclaw, Poland.
EM krzysztofmarycz@interia.pl
RI Nicpoń, Jakub/A-4955-2017; Marycz, Krzysztof/A-2249-2017
OI Nicpon, Jakub/0000-0002-8168-6301
FU Wroclaw Centre of Biotechnology, programme the Leading National Research
   Centre (KNOW)
FX Publication supported by Wroclaw Centre of Biotechnology, programme the
   Leading National Research Centre (KNOW) for years 2014-2018.
CR Almeida M, 2011, BONE, V49, P319, DOI 10.1016/j.bone.2011.05.023
   Altomonte J, 2003, AM J PHYSIOL-ENDOC M, V285, pE718, DOI 10.1152/ajpendo.00156.2003
   Aymard E, 2011, EXP DERMATOL, V20, P263, DOI 10.1111/j.1600-0625.2010.01157.x
   Baksh D, 2007, STEM CELLS, V25, P1384, DOI 10.1634/stemcells.2006-0709
   Balaban RS, 2005, CELL, V120, P483, DOI 10.1016/j.cell.2005.02.001
   Barone AAL, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/383685
   Bartell SM, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4773
   Basinska K, 2015, J VET SCI, V16, P113, DOI [10.4142/jvs.2015.16.1.113, 10.4142/jvs.2015.16.1.107]
   Bayarsaihan D, 2011, J DENT RES, V90, P9, DOI 10.1177/0022034510378683
   Benameur L, 2015, BIO-MED MATER ENG, V25, pS41, DOI 10.3233/BME-141247
   Blazquez R, 2014, FRONT IMMUNOL, V5, DOI 10.3389/fimmu.2014.00556
   Bonora E, 1998, DIABETES, V47, P1643, DOI 10.2337/diabetes.47.10.1643
   Boudina S, 2014, EXP PHYSIOL, V99, P1168, DOI 10.1113/expphysiol.2014.081414
   Chen CT, 2008, STEM CELLS, V26, P960, DOI 10.1634/stemcells.2007-0509
   Chen D, 2004, GROWTH FACTORS, V22, P233, DOI 10.1080/08977190412331279890
   Chen T, 2009, CELL BIOL TOXICOL, V25, P573, DOI 10.1007/s10565-008-9113-7
   Chen Y, 2009, CELL DEATH DIFFER, V16, P1040, DOI 10.1038/cdd.2009.49
   CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1006/abio.1987.9999
   Collino F, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011803
   Cuervo AM, 2005, AUTOPHAGY, V1, P131, DOI 10.4161/auto.1.3.2017
   Dave KD, 2014, NEUROBIOL DIS, V70, P190, DOI 10.1016/j.nbd.2014.06.009
   De Schauwer C, 2013, VET QUART, V33, P234, DOI 10.1080/01652176.2013.800250
   Del Bue M, 2008, VET RES COMMUN, V32, pS51, DOI 10.1007/s11259-008-9093-3
   Dentelli P, 2013, DIABETOLOGIA, V56, P173, DOI 10.1007/s00125-012-2734-7
   Diaz F, 2008, CELL CALCIUM, V44, P24, DOI 10.1016/j.ceca.2007.12.004
   Ding WX, 2012, BIOL CHEM, V393, P547, DOI 10.1515/hsz-2012-0119
   Durham AE, 2009, EQUINE VET J, V41, P924, DOI 10.2746/042516409X452152
   Firshman AM, 2007, EQUINE VET J, V39, P567, DOI 10.2746/042516407X238512
   Forni MF, 2016, STEM CELLS, V34, P743, DOI 10.1002/stem.2248
   Frank N, 2009, J EQUINE VET SCI, V29, P259, DOI 10.1016/j.jevs.2009.04.183
   Goff JP, 1997, J DAIRY SCI, V80, P1260, DOI 10.3168/jds.S0022-0302(97)76055-7
   Gonzalez R, 2007, BIOCHEM BIOPH RES CO, V362, P491, DOI 10.1016/j.bbrc.2007.08.033
   Green DR, 2014, CELL, V157, P65, DOI 10.1016/j.cell.2014.02.049
   GRUMMER RR, 1993, J DAIRY SCI, V76, P3882, DOI 10.3168/jds.S0022-0302(93)77729-2
   Grzesiak Jakub, 2011, Int J Stem Cells, V4, P99
   Guo M, 2012, CSH PERSPECT MED, V2, DOI 10.1101/cshperspect.a009944
   Hashemian SJ, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/675103
   Horvath S, 2013, GENOME BIOL, V14, DOI 10.1186/gb-2013-14-10-r115
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Jin SM, 2012, J CELL SCI, V125, P795, DOI 10.1242/jcs.093849
   Johnson PJ, 2010, VET CLIN N AM-EQUINE, V26, P239, DOI 10.1016/j.cveq.2010.04.004
   Joshi A, 2013, AUTOPHAGY, V9, P1737, DOI 10.4161/auto.26681
   Kang HS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0058417
   Katayama M, 2007, CELL DEATH DIFFER, V14, P548, DOI 10.1038/sj.cdd.4402030
   Kim AY, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8585
   Kim N, 2013, KOREAN J INTERN MED, V28, P387, DOI 10.3904/kjim.2013.28.4.387
   Kita K, 2010, STEM CELLS DEV, V19, P491, DOI 10.1089/scd.2009.0192
   Kodama K, 2015, DIABETES, V64, P867, DOI 10.2337/db14-0149
   Kodama K, 2012, P NATL ACAD SCI USA, V109, P7049, DOI 10.1073/pnas.1114513109
   Li WJ, 2005, BIOMATERIALS, V26, P5158, DOI 10.1016/j.biomaterials.2005.01.002
   Mandal S, 2011, STEM CELLS, V29, P486, DOI 10.1002/stem.590
   Maredziak M, 2015, IN VITRO CELL DEV-AN, V51, P230, DOI 10.1007/s11626-014-9828-0
   Maredziak M, 2014, IN VITRO CELL DEV-AN, V50, P562, DOI 10.1007/s11626-013-9730-1
   Marycz K, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/4710326
   Morino K, 2005, J CLIN INVEST, V115, P3587, DOI 10.1172/JCI25151
   Nicpon J, 2013, POL J VET SCI, V16, P753, DOI 10.2478/pjvs-2013-0107
   Nixon RA, 2013, NAT MED, V19, P983, DOI 10.1038/nm.3232
   Nombela-Arrieta C, 2011, NAT REV MOL CELL BIO, V12, P126, DOI 10.1038/nrm3049
   Nuschke A, 2014, STEM CELL RES THER, V5, DOI 10.1186/scrt530
   Pan GJ, 2002, CELL RES, V12, P321, DOI 10.1038/sj.cr.7290134
   Páramo B, 2010, NEUROSCIENCE, V167, P1057, DOI 10.1016/j.neuroscience.2010.02.074
   Pesah Y, 2004, DEVELOPMENT, V131, P2183, DOI 10.1242/dev.01095
   Petersen Kitt Falk, 2004, N Engl J Med, V350, P664
   Pileggi A, 2012, DIABETES, V61, P1355, DOI 10.2337/db12-0355
   Prowse ABJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0052214
   Quan W, 2012, EXP MOL MED, V44, P81, DOI 10.3858/emm.2012.44.2.030
   Rahavi H, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/878535
   Ratajczak J, 2006, LEUKEMIA, V20, P1487, DOI 10.1038/sj.leu.2404296
   Ratajczak J, 2006, LEUKEMIA, V20, P847, DOI 10.1038/sj.leu.2404132
   Ratajczak MZ, 2008, BLOOD, V111, P4832, DOI 10.1182/blood-2008-02-136028
   Robertson RP, 2004, DIABETES, V53, pS119, DOI 10.2337/diabetes.53.2007.S119
   Samocha-Bonet D, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036320
   SHIGENAGA MK, 1994, P NATL ACAD SCI USA, V91, P10771, DOI 10.1073/pnas.91.23.10771
   Singh R, 2011, CELL METAB, V13, P495, DOI 10.1016/j.cmet.2011.04.004
   Tanaka A, 2010, FEBS LETT, V584, P1386, DOI 10.1016/j.febslet.2010.02.060
   Tantrawatpan Chairat, 2013, Journal of the Medical Association of Thailand, V96, P1208
   Tropel P, 2004, EXP CELL RES, V295, P395, DOI 10.1016/j.yexcr.2003.12.030
   Wei X, 2013, ACTA PHARMACOL SIN, V34, P747, DOI 10.1038/aps.2013.50
   Wongdee K, 2011, WORLD J DIABETES, V2, P41, DOI 10.4239/wjd.v2.i3.41
   Yang ZNJ, 2011, MOL CANCER THER, V10, P1533, DOI 10.1158/1535-7163.MCT-11-0047
   Zhao JY, 2012, DIABETES, V61, P542, DOI 10.2337/db11-1048
   Zhao K, 2015, CELL DEATH DIS, V6, DOI 10.1038/cddis.2015.230
   Zhao Y, 2012, J CELL PHYSIOL, V227, P639, DOI 10.1002/jcp.22768
   Zhou JY, 2012, AUTOPHAGY, V8, P1712, DOI 10.4161/auto.21830
NR 84
TC 65
Z9 68
U1 0
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1582-1838
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD DEC
PY 2016
VL 20
IS 12
BP 2384
EP 2404
DI 10.1111/jcmm.12932
PG 21
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA ED8WY
UT WOS:000389152800018
PM 27629697
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, B
   Kang, YT
   Mendelson, FE
   Hayes, JM
   Savelieff, MG
   Nagrath, S
   Feldman, EL
AF Kim, Bhumsoo
   Kang, Yoon-Tae
   Mendelson, Faye E.
   Hayes, John M.
   Savelieff, Masha G.
   Nagrath, Sunitha
   Feldman, Eva L.
TI Palmitate and glucose increase amyloid precursor protein in
   extracellular vesicles: Missing link between metabolic syndrome and
   Alzheimer's disease
SO JOURNAL OF EXTRACELLULAR VESICLES
LA English
DT Article
DE Alzheimer's disease; amyloid precursor protein; diabetes; extracellular
   vesicles; insulin resistance; metabolic syndrome; obesity; tau
ID INSULIN-RECEPTOR SUBSTRATE; A-BETA; TERMINAL FRAGMENTS; FATTY-ACIDS;
   MOUSE MODEL; RESISTANCE; PHOSPHORYLATION; BRAIN; DYSFUNCTION; EXOSOMES
AB The metabolic syndrome (MetS) and Alzheimer's disease share several pathological features, including insulin resistance, abnormal protein processing, mitochondrial dysfunction and elevated inflammation and oxidative stress. The MetS constitutes elevated fasting glucose, obesity, dyslipidaemia and hypertension and increases the risk of developing Alzheimer's disease, but the precise mechanism remains elusive. Insulin resistance, which develops from a diet rich in sugars and saturated fatty acids, such as palmitate, is shared by the MetS and Alzheimer's disease. Extracellular vesicles (EVs) are also a point of convergence, with altered dynamics in both the MetS and Alzheimer's disease. However, the role of palmitate- and glucose-induced insulin resistance in the brain and its potential link through EVs to Alzheimer's disease is unknown. We demonstrate that palmitate and high glucose induce insulin resistance and amyloid precursor protein phosphorylation in primary rat embryonic cortical neurons and human cortical stem cells. Palmitate also triggers insulin resistance in oligodendrocytes, the supportive glia of the brain. Palmitate and glucose enhance amyloid precursor protein secretion from cortical neurons via EVs, which induce tau phosphorylation when added to na & iuml;ve neurons. Additionally, EVs from palmitate-treated oligodendrocytes enhance insulin resistance in recipient neurons. Overall, our findings suggest a novel theory underlying the increased risk of Alzheimer's disease in MetS mediated by EVs, which spread Alzheimer's pathology and insulin resistance.
C1 [Kim, Bhumsoo; Mendelson, Faye E.; Hayes, John M.; Feldman, Eva L.] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA.
   [Kim, Bhumsoo; Mendelson, Faye E.; Hayes, John M.; Savelieff, Masha G.; Feldman, Eva L.] Univ Michigan, NeuroNetwork Emerging Therapies, Ann Arbor, MI 48109 USA.
   [Kang, Yoon-Tae; Nagrath, Sunitha] Univ Michigan, Dept Chem Engn, Ann Arbor, MI 48109 USA.
   [Kang, Yoon-Tae; Nagrath, Sunitha] Univ Michigan, Biointerfaces Inst, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; University of Michigan System;
   University of Michigan; University of Michigan System; University of
   Michigan
RP Feldman, EL (corresponding author), Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA.
EM efeldman@umich.edu
RI Kang, Yoon-Tae/AAL-6732-2020
OI Kim, Bhumsoo/0000-0002-2645-1673
FU Sinai Medical Staff Foundation; National Institutes of Health
   [R01DK130913, U24DK115255]; A. Alfred Taubman Medical Research
   Institute; NeuroNetwork for Emerging Therapies; Andrea and Lawrence A.
   Wolfe Brain Health Initiative Fund; Robert E. Nederlander Sr. Program
   for Alzheimer's Research; Michigan Diabetes Research Center for the
   confocal imaging to Michigan Diabetes Research Center for the confocal
   imaging [P30DK02572]; National Institute of Diabetes and Digestive and
   Kidney Diseases [R01DK130913] Funding Source: NIH RePORTER
FX Sinai Medical Staff Foundation; National Institutes of Health,
   Grant/Award Numbers: R01DK130913, U24DK115255; A. Alfred Taubman Medical
   Research Institute; NeuroNetwork for Emerging Therapies; Andrea and
   Lawrence A. Wolfe Brain Health Initiative Fund; Robert E. Nederlander
   Sr. Program for Alzheimer's Research; Michigan Diabetes Research Center
   for the confocal imaging to Michigan Diabetes Research Center for the
   confocal imaging, Grant/Award Number: P30DK02572
CR Ahn JH, 2016, BMB REP, V49, P376, DOI 10.5483/BMBRep.2016.49.7.246
   Akbar N, 2019, DIABETOLOGIA, V62, P2179, DOI 10.1007/s00125-019-05014-5
   Andrew RJ, 2016, J BIOL CHEM, V291, P19235, DOI 10.1074/jbc.R116.746032
   Aswad H, 2014, DIABETOLOGIA, V57, P2155, DOI 10.1007/s00125-014-3337-2
   Barron AM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0078554
   Beydoun MA, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-643
   Biessels GJ, 2018, NAT REV ENDOCRINOL, V14, P591, DOI 10.1038/s41574-018-0048-7
   Nakandakari SCBR, 2019, BRAIN BEHAV IMMUN, V79, P284, DOI 10.1016/j.bbi.2019.02.016
   Busquets O, 2017, MECH AGEING DEV, V162, P38, DOI 10.1016/j.mad.2016.11.002
   Campos-Peña V, 2017, ANTIOXID REDOX SIGN, V26, P542, DOI 10.1089/ars.2016.6768
   Chen JF, 2021, NEURON, V109, P2292, DOI 10.1016/j.neuron.2021.05.012
   Chen WQ, 2022, TRENDS NEUROSCI, V45, P384, DOI 10.1016/j.tins.2022.03.001
   Chen YF, 2020, AGING-US, V12, P18274, DOI 10.18632/aging.103692
   Cobbs A, 2019, MOL CELL BIOCHEM, V458, P113, DOI 10.1007/s11010-019-03535-6
   Copps KD, 2012, DIABETOLOGIA, V55, P2565, DOI 10.1007/s00125-012-2644-8
   Deleo AM, 2018, J NEUROIMMUNE PHARM, V13, P292, DOI 10.1007/s11481-017-9768-z
   Di Marco LY, 2015, NEUROBIOL DIS, V82, P593, DOI 10.1016/j.nbd.2015.08.014
   Dinkins MB, 2017, J ALZHEIMERS DIS, V60, P757, DOI 10.3233/JAD-160567
   Eguchi A, 2016, J MOL MED, V94, P1241, DOI 10.1007/s00109-016-1446-8
   Elzinga SE, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.1012594
   Freeman DW, 2018, DIABETES, V67, P2377, DOI 10.2337/db17-1308
   Frühbeis C, 2020, PLOS BIOL, V18, DOI 10.1371/journal.pbio.3000621
   Fukushima M, 2018, J BIOL CHEM, V293, P15277, DOI 10.1074/jbc.RA118.002587
   Gasparini L, 2001, J NEUROSCI, V21, P2561, DOI 10.1523/JNEUROSCI.21-08-02561.2001
   Gerakis Y, 2018, FEBS J, V285, P995, DOI 10.1111/febs.14332
   Grandl G, 2018, SEMIN IMMUNOPATHOL, V40, P215, DOI 10.1007/s00281-017-0666-5
   Grote CW, 2016, FRONT NEUROSCI-SWITZ, V10, DOI 10.3389/fnins.2016.00581
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Guo XF, 2017, NUTRIENTS, V9, DOI 10.3390/nu9070703
   Helwa I, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0170628
   Henn RE, 2022, NEUROBIOL DIS, V170, DOI 10.1016/j.nbd.2022.105766
   Hirsova P, 2016, GASTROENTEROLOGY, V150, P956, DOI 10.1053/j.gastro.2015.12.037
   Johe KK, 1996, GENE DEV, V10, P3129, DOI 10.1101/gad.10.24.3129
   Kapogiannis D, 2015, FASEB J, V29, P589, DOI 10.1096/fj.14-262048
   Kellar D, 2020, LANCET NEUROL, V19, P758, DOI 10.1016/S1474-4422(20)30231-3
   Kim B, 2019, NEUROBIOL DIS, V132, DOI 10.1016/j.nbd.2019.104541
   Kim B, 2015, J BIOL CHEM, V290, P19146, DOI 10.1074/jbc.M115.636852
   Kim B, 2015, EXP MOL MED, V47, DOI 10.1038/emm.2015.3
   Kim B, 2013, J ALZHEIMERS DIS, V34, P727, DOI 10.3233/JAD-121669
   Kim B, 2012, TRENDS ENDOCRIN MET, V23, P133, DOI 10.1016/j.tem.2011.12.004
   Kim B, 2011, ENDOCRINOLOGY, V152, P3638, DOI 10.1210/en.2011-0029
   Kim B, 2011, ANTIOXID REDOX SIGN, V14, P1829, DOI 10.1089/ars.2010.3816
   Kim B, 2009, ENDOCRINOLOGY, V150, P5294, DOI 10.1210/en.2009-0695
   Kim J, 2011, BRAIN RES, V1418, P42, DOI 10.1016/j.brainres.2011.08.059
   Kowal J, 2016, P NATL ACAD SCI USA, V113, pE968, DOI 10.1073/pnas.1521230113
   Kwon B, 2014, BBA-MOL CELL RES, V1843, P1402, DOI 10.1016/j.bbamcr.2014.04.004
   Laulagnier K, 2018, CELL MOL LIFE SCI, V75, P757, DOI 10.1007/s00018-017-2664-0
   Lee MS, 2003, J CELL BIOL, V163, P83, DOI 10.1083/jcb.200301115
   Lombino F, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057120
   Martínez MC, 2017, CIRC RES, V120, P1674, DOI 10.1161/CIRCRESAHA.117.309419
   Marwarha G, 2019, J ALZHEIMERS DIS, V68, P219, DOI [10.3233/JAD-180835, 10.3233/jad-180835]
   Marwarha G, 2017, J ALZHEIMERS DIS, V57, P907, DOI 10.3233/JAD-161130
   Matioli Maria Niures P.S., 2015, Dement. neuropsychol., V9, P96, DOI 10.1590/1980-57642015DN92000003
   Matsushima T, 2012, J BIOL CHEM, V287, P19715, DOI 10.1074/jbc.M111.334847
   Miranda AM, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-017-02533-w
   Mohan S, 2019, EUR J PHARMACOL, V860, DOI 10.1016/j.ejphar.2019.172553
   Mullins RJ, 2017, HUM BRAIN MAPP, V38, P1933, DOI 10.1002/hbm.23494
   Nasrabady SE, 2018, ACTA NEUROPATHOL COM, V6, DOI 10.1186/s40478-018-0515-3
   Neth BJ, 2017, FRONT AGING NEUROSCI, V9, DOI 10.3389/fnagi.2017.00345
   O'Grady JP, 2019, OBESITY, V27, P1464, DOI 10.1002/oby.22558
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Ono H, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20061317
   Oyarce K, 2022, FRONT CELL NEUROSCI, V16, DOI 10.3389/fncel.2022.920686
   Palomer X, 2018, TRENDS ENDOCRIN MET, V29, P178, DOI 10.1016/j.tem.2017.11.009
   Pandini G, 2013, ENDOCRINOLOGY, V154, P375, DOI 10.1210/en.2012-1661
   Pardo F, 2018, MOL ASPECTS MED, V60, P81, DOI 10.1016/j.mam.2017.11.010
   Patil S, 2006, NEUROSCI LETT, V406, P55, DOI 10.1016/j.neulet.2006.07.015
   Pedditizi E, 2016, AGE AGEING, V45, P14, DOI 10.1093/ageing/afv151
   Pérez-González R, 2020, FASEB J, V34, P12922, DOI 10.1096/fj.202000823R
   Power MC, 2018, ALZHEIMERS DEMENT, V14, P167, DOI 10.1016/j.jalz.2017.07.757
   Ramelot TA, 2001, J MOL BIOL, V307, P871, DOI 10.1006/jmbi.2001.4535
   Rollins CPE, 2019, NEUROIMAGE-CLIN, V21, DOI 10.1016/j.nicl.2018.11.016
   Rumora AE, 2019, J NEUROSCI, V39, P3770, DOI 10.1523/JNEUROSCI.3173-18.2019
   Rumora AE, 2018, FASEB J, V32, P195, DOI 10.1096/fj.201700206R
   Sadahiro R, 2019, PSYCHIAT CLIN NEUROS, V73, P597, DOI 10.1111/pcn.12905
   Savelieff MG, 2013, ACS CHEM BIOL, V8, P856, DOI 10.1021/cb400080f
   Sims-Robinson C, 2010, NAT REV NEUROL, V6, P551, DOI 10.1038/nrneurol.2010.130
   Sinha MS, 2018, ACTA NEUROPATHOL, V136, P41, DOI 10.1007/s00401-018-1868-1
   Solfrizzi V, 2011, EXPERT REV NEUROTHER, V11, P677, DOI [10.1586/ERN.11.56, 10.1586/ern.11.56]
   Soo CY, 2012, IMMUNOLOGY, V136, P192, DOI 10.1111/j.1365-2567.2012.03569.x
   Standen CL, 2001, J NEUROCHEM, V76, P316, DOI 10.1046/j.1471-4159.2001.00102.x
   Takeda S, 2010, P NATL ACAD SCI USA, V107, P7036, DOI 10.1073/pnas.1000645107
   Théry C, 2018, J EXTRACELL VESICLES, V7, DOI 10.1080/20013078.2018.1535750
   Tortosa-Caparrós E, 2017, CRIT REV FOOD SCI, V57, P3421, DOI 10.1080/10408398.2015.1126549
   Van Dyken P, 2018, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00930
   van Niel G, 2018, NAT REV MOL CELL BIO, V19, P213, DOI 10.1038/nrm.2017.125
   Vanzulli I, 2020, NEUROBIOL AGING, V94, P130, DOI 10.1016/j.neurobiolaging.2020.05.016
   Vella LJ, 2017, J EXTRACELL VESICLES, V6, DOI 10.1080/20013078.2017.1348885
   Verderio C, 2018, J LIPID RES, V59, P1325, DOI 10.1194/jlr.R083915
   Verdile G, 2015, MEDIAT INFLAMM, V2015, DOI 10.1155/2015/105828
   Vincent AM, 2005, FASEB J, V19, P638, DOI 10.1096/fj.04-2513fje
   Vingtdeux V, 2005, NEUROBIOL DIS, V20, P625, DOI 10.1016/j.nbd.2005.05.004
   Vinuesa A, 2019, MOL NEUROBIOL, V56, P5075, DOI 10.1007/s12035-018-1435-8
   Wang Y, 2017, MOL NEURODEGENER, V12, DOI [10.1186/s13024-016-0143-y, 10.1007/s12293-017-0248-z]
   Winston Charisse N, 2016, Alzheimers Dement (Amst), V3, P63, DOI 10.1016/j.dadm.2016.04.001
   Xiao TT, 2017, TRANSL NEURODEGENER, V6, DOI [10.1186/s40035-017-0072-x, 10.1186/s40035-017-0081-9]
   Yarza R, 2016, FRONT PHARMACOL, V6, DOI 10.3389/fphar.2015.00321
NR 97
TC 9
Z9 9
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2001-3078
J9 J EXTRACELL VESICLES
JI J. Extracell. Vesicles
PD NOV
PY 2023
VL 12
IS 11
AR e12340
DI 10.1002/jev2.12340
PG 16
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA W4ZM1
UT WOS:001091724500001
PM 37898562
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU D'Alonzo, KT
   Garsman, L
AF D'Alonzo, Karen T.
   Garsman, Lisa
TI The Impact of Childhood Growth Stunting and Post-Migration Dysbiosis on
   the Development of Metabolic Syndrome Among Indigenous Immigrant Mexican
   Women
SO BIOLOGICAL RESEARCH FOR NURSING
LA English
DT Article
DE metabolic syndrome; childhood growth stunting; dysbiosis; immigrant
   health
ID RISK-FACTORS; EARLY-LIFE; ENVIRONMENTAL ENTEROPATHY; GUT MICROBIOTA;
   CARDIOVASCULAR-DISEASE; INTESTINAL MICROBIOTA; PREVALENCE; STRESS;
   HEALTH; NUTRITION
AB While weight gain is common following migration to a new country and Mexican Americans have a disparate prevalence of overweight and obesity. In particular, Mexican American women have one of the world's highest rates of Metabolic Syndrome (MetS), characterized by abdominal obesity, insulin resistance, hypertension, and dyslipidemia, all of which increase the risk for atherosclerotic cardiovascular disease (CVD). Although the etiology of this dilemma is not well understood, using the framework of allostatic load (AL), we posit that exposure to multiple physiologic, psychosocial and environmental stressors over the course of the lifespan may contribute to an increased risk of MetS among indigenous Mexican immigrant women. Two such frequently overlooked stressors are: 1) a history of childhood growth stunting (CGS) and 2) dietary changes post migration that result in decreased diversity of the gut microbiome (dysbiosis). To date, little is known about how migration experiences differentially affect the relationship between CGS and MetS in adulthood. The purpose of this theoretical article is to present a proposed model of how early life stressors (ELS), specifically CGS, may interact with insalubrious aspects of the immigration experience to promote an increased risk for MetS among indigenous Mexican immigrant women. This model may be used in a bi-national effort to guide intervention efforts to decrease CGS in Mexico and to prevent, monitor or delay the components of MetS post migration in the US.
C1 [D'Alonzo, Karen T.] Rutgers State Univ, Sch Nursing, Newark, NJ USA.
   [Garsman, Lisa] St Peters Univ, Sch Nursing, Jersey City, NJ USA.
C3 Rutgers University System; Rutgers University Newark; Rutgers University
   New Brunswick
RP D'Alonzo, KT (corresponding author), Rutgers State Univ, Sch Nursing, 110 Paterson St, New Brunswick, NJ 08901 USA.
EM kdalonzo@rutgers.edu
RI D'Alonzo, Karen/GSM-6563-2022
OI Garsman, Lisa/0000-0001-6598-255X
CR Agorastos A, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00118
   Albrecht SS, 2013, OBESITY, V21, P1695, DOI 10.1002/oby.20104
   Barquera S, 2007, INT J OBESITY, V31, P601, DOI 10.1038/sj.ijo.0803529
   Breban M, 2016, JOINT BONE SPINE, V83, P645, DOI 10.1016/j.jbspin.2016.04.005
   Collado MC, 2012, GUT MICROBES, V3, P352, DOI 10.4161/gmic.21215
   Castro-Porras LV, 2018, REV PANAM SALUD PUBL, V42, DOI 10.26633/RPSP.2018.29
   Cetthakrikul N, 2018, BMC PEDIATR, V18, DOI 10.1186/s12887-018-1375-5
   Chavez A., 2011, AM DIAB ASS ADA 71 S
   Checkley W, 2008, INT J EPIDEMIOL, V37, P816, DOI 10.1093/ije/dyn099
   Claesson MJ, 2012, NATURE, V488, P178, DOI 10.1038/nature11319
   Comision Nacional para el Desarrollo de los Pueblos Indigenas, 2014, PROGR ESP LOS PUEBL
   D'Alonzo KT, 2020, PROG COMM HLTH PARTN, V14, P173, DOI 10.1353/cpr.2020.0016
   D'Alonzo KT, 2019, REV LAT-AM ENFERM, V27
   Daskalakis NP, 2013, PSYCHONEUROENDOCRINO, V38, P1858, DOI 10.1016/j.psyneuen.2013.06.008
   DeBoer MD, 2012, NUTR REV, V70, P642, DOI 10.1111/j.1753-4887.2012.00543.x
   Derrien M, 2017, TRENDS MICROBIOL, V25, P100, DOI 10.1016/j.tim.2016.09.011
   Dewey KG, 2011, MATERN CHILD NUTR, V7, P5, DOI 10.1111/j.1740-8709.2011.00349.x
   Díaz-Zavala RG, 2019, DIABET METAB SYND OB, V12, P1841, DOI 10.2147/DMSO.S208884
   Dominguez-Bello MG, 2010, P NATL ACAD SCI USA, V107, P11971, DOI 10.1073/pnas.1002601107
   Emanuela F, 2012, J NUTR METAB, V2012, DOI 10.1155/2012/476380
   Fernald LC, 2007, EUR J CLIN NUTR, V61, P623, DOI 10.1038/sj.ejcn.1602558
   Frisco M. L., 2019, IMMIGRATION HLTH, P71
   Giuntella O, 2020, J INT ECON, V122, DOI 10.1016/j.jinteco.2019.103277
   González-de Cossío T, 2009, SALUD PUBLICA MEXICO, V51, pS494
   Gough EK, 2015, CLIN INFECT DIS, V61, pS738, DOI 10.1093/cid/civ850
   Guerrant RL, 2013, NAT REV GASTRO HEPAT, V10, P220, DOI 10.1038/nrgastro.2012.239
   Hakansson A, 2011, NUTRIENTS, V3, P637, DOI 10.3390/nu3060637
   Heiss G, 2014, DIABETES CARE, V37, P2391, DOI 10.2337/dc13-2505
   Henriques A, 2018, PUBLIC HEALTH NUTR, V21, P1819, DOI [10.1017/S1368980018000460, 10.1017/s1368980018000460]
   Ho JS, 2008, AM J CARDIOL, V102, P689, DOI 10.1016/j.amjcard.2008.05.010
   Hoffman DJ, 2017, ANN HUM BIOL, V44, P201, DOI 10.1080/03014460.2016.1267261
   Hoffman DJ, 2000, AM J CLIN NUTR, V72, P702
   Hoffman KL, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194100
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   INEGI Instituto Nacional de Estadistica y Geografia, 2015, RES DEF ENC INT 2015
   Institute for Mexicans Abroad, 2015, DO YOU KNOW MAN MEX
   Kaestner R, 2009, SOC SCI QUART, V90, P1089, DOI 10.1111/j.1540-6237.2009.00648.x
   Kaplan RC, 2019, GENOME BIOL, V20, DOI 10.1186/s13059-019-1831-z
   Kensara OA, 2006, AM J PHYSIOL-ENDOC M, V291, pE365, DOI 10.1152/ajpendo.00599.2005
   Korpe PS, 2012, TRENDS MOL MED, V18, P328, DOI 10.1016/j.molmed.2012.04.007
   Kroker-Lobos MF, 2014, AM J CLIN NUTR, V100, p1652S, DOI 10.3945/ajcn.114.083832
   Lang Dennis, 2015, Microbial Ecology in Health and Disease, V26, P28316, DOI 10.3402/mehd.v26.28316
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Lee GO, 2017, J DEV ORIG HLTH DIS, V8, P337, DOI 10.1017/S2040174417000071
   Lee SK, 2015, J DEV ORIG HLTH DIS, V6, P291, DOI 10.1017/S204017441500118X
   Levy M, 2017, NAT REV IMMUNOL, V17, P219, DOI 10.1038/nri.2017.7
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Lindberg NM, 2011, J IMMIGR MINOR HEALT, V13, P155, DOI 10.1007/s10903-009-9298-8
   Lloyd-Jones D, 2010, CIRCULATION, V121, pE46, DOI 10.1161/CIRCULATIONAHA.109.192667
   Martorell Reynaldo, 2005, Prev Chronic Dis, V2, pA04
   MATA LJ, 1972, AM J CLIN NUTR, V25, P1267
   Matamoros S, 2013, TRENDS MICROBIOL, V21, P167, DOI 10.1016/j.tim.2012.12.001
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   Mohammadkhah AI, 2018, CHILDREN-BASEL, V5, DOI 10.3390/children5120160
   Morales LS, 2014, SALUD PUBLICA MEXICO, V56, P197
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Mozaffarian D, 2014, NEW ENGL J MED, V371, P624, DOI 10.1056/NEJMoa1304127
   Nederhof E, 2012, PHYSIOL BEHAV, V106, P691, DOI 10.1016/j.physbeh.2011.12.008
   Oza-Frank R, 2010, OBES REV, V11, P271, DOI 10.1111/j.1467-789X.2009.00610.x
   Özaltin E, 2010, JAMA-J AM MED ASSOC, V303, P1507, DOI 10.1001/jama.2010.450
   Pacheco LS, 2018, BMC PUBLIC HEALTH, V18, DOI 10.1186/s12889-018-6276-x
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Passel J.S., 2014, As growth stalls, unauthorized immigrant population becomes more settled
   Peterson LW, 2014, NAT REV IMMUNOL, V14, P141, DOI 10.1038/nri3608
   Puchner KP, 2017, REV PANAM SALUD PUBL, V41, DOI 10.26633/RPSP.2017.32
   Radford J., 2019, Key findings about U.S. immigrants
   Rajoka MSR, 2017, FOOD SCI HUM WELL, V6, P121, DOI 10.1016/j.fshw.2017.07.003
   Riosmena F, 2012, ANN ASSOC AM GEOGR, V102, P1209, DOI 10.1080/00045608.2012.659629
   Rolfe ED, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0192196
   Rothschild D, 2018, NATURE, V555, P210, DOI 10.1038/nature25973
   Santiago-Torres M, 2016, AM J CLIN NUTR, V103, P366, DOI 10.3945/ajcn.115.119016
   Vangay P, 2018, CELL, V175, P962, DOI 10.1016/j.cell.2018.10.029
   Vienrich AB, 2019, SOCIOL COMPASS, V13, DOI 10.1111/soc4.12644
   Watanabe K, 2016, EBIOMEDICINE, V10, P25, DOI 10.1016/j.ebiom.2016.07.030
   Woldehanna T, 2017, ETHIOP J HEALTH DEV, V31, P75
   Yatsunenko T, 2012, NATURE, V486, P222, DOI 10.1038/nature11053
   Zhang HS, 2015, ISME J, V9, P770, DOI 10.1038/ismej.2014.165
NR 77
TC 2
Z9 2
U1 2
U2 9
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1099-8004
EI 1552-4175
J9 BIOL RES NURS
JI Biol. Res. Nurs.
PD OCT
PY 2020
VL 22
IS 4
SI SI
BP 552
EP 560
AR 1099800420941599
DI 10.1177/1099800420941599
EA JUL 2020
PG 9
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA NV8BS
UT WOS:000548874500001
PM 32666821
DA 2025-06-11
ER

PT J
AU Patruno, I
   Thompson, D
   Dall'Angelo, S
   Windhorst, AD
   Vugts, DJ
   Poot, AJ
   Mody, N
   Zanda, M
AF Patruno, Ilaria
   Thompson, Dawn
   Dall'Angelo, Sergio
   Windhorst, Albert D.
   Vugts, Danielle J.
   Poot, Alex J.
   Mody, Nimesh
   Zanda, Matteo
TI Design, Synthesis, Radiosynthesis and Biological Evaluation of
   Fenretinide Analogues as Anticancer and Metabolic Syndrome-Preventive
   Agents
SO CHEMMEDCHEM
LA English
DT Article
DE cancer; drug discovery; fenretinide; metabolic syndrome;
   radiopharmaceuticals
ID DIET-INDUCED OBESITY; DIHYDROCERAMIDE DESATURASE; HIGH-FAT; SPHINGOSINE
   KINASE; APOPTOSIS; N-(4-HYDROXYPHENYL)RETINAMIDE; STRESS; PET;
   DIFFERENTIATION; DERIVATIVES
AB Fenretinide (4-HPR) is a synthetic derivative of all-trans-retinoic acid (ATRA) characterised by improved therapeutic properties and toxicological profile relative to ATRA. 4-HPR has been mostly investigated as an anti-cancer agent, but recent studies showed its promising therapeutic potential for preventing metabolic syndrome. Several biological targets are involved in 4-HPR's activity, leading to the potential use of this molecule for treating different pathologies. However, although 4-HPR displays quite well-understood multitarget promiscuity with regards to pharmacology, interpreting its precise physiological role remains challenging. In addition, despite promising resultsin vitro, the clinical efficacy of 4-HPR as a chemotherapeutic agent has not been satisfactory so far. Herein, we describe the preparation of a library of 4-HPR analogues, followed by the biological evaluation of their anti-cancer and anti-obesity/diabetic properties. The click-type analogue3 bshowed good capacity to reduce the amount of lipid accumulation in 3T3-L1 adipocytes during differentiation. Furthermore, it showed an IC(50)of 0.53 +/- 0.8 mu M in cell viability tests on breast cancer cell line MCF-7, together with a good selectivity (SI=121) over noncancerous HEK293 cells. Thus,3 bwas selected as a potential PET tracer to study retinoidsin vivo, and the radiosynthesis of [F-18]3bwas successfully developed. Unfortunately, the stability of [F-18]3bturned out to be insufficient to pursue imaging studies.
C1 [Patruno, Ilaria; Thompson, Dawn; Dall'Angelo, Sergio; Mody, Nimesh; Zanda, Matteo] Univ Aberdeen, Inst Med Sci, Aberdeen AB25 2ZD, Scotland.
   [Windhorst, Albert D.; Vugts, Danielle J.; Poot, Alex J.] Vrije Univ Amsterdam Med Ctr, Canc Ctr Amsterdam, Amsterdam UMC, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands.
   [Zanda, Matteo] CNR SCITEC, Via Mancinelli 7, I-20131 Milan, Italy.
   [Zanda, Matteo] Loughborough Univ, Sch Sci, Ctr Sensing & Imaging Sci, Sir David Davies Bldg, Loughborough LE11 3TU, Leics, England.
C3 University of Aberdeen; Vrije Universiteit Amsterdam; VU UNIVERSITY
   MEDICAL CENTER; Consiglio Nazionale delle Ricerche (CNR); Istituto di
   Scienze Tecnologie Chimiche "Giulio Natta" (SCITEC-CNR); Loughborough
   University
RP Mody, N; Zanda, M (corresponding author), Univ Aberdeen, Inst Med Sci, Aberdeen AB25 2ZD, Scotland.; Zanda, M (corresponding author), CNR SCITEC, Via Mancinelli 7, I-20131 Milan, Italy.; Zanda, M (corresponding author), Loughborough Univ, Sch Sci, Ctr Sensing & Imaging Sci, Sir David Davies Bldg, Loughborough LE11 3TU, Leics, England.
EM n.mody@abdn.ac.uk; m.zanda@lboro.ac.uk
RI Vercouillie, Johnny/K-8938-2014; Mody, Nimesh/J-9602-2019; Zanda,
   Matteo/AAC-2391-2022; Dall'Angelo, Sergio/J-5333-2014
OI Mody, Nimesh/0000-0002-2215-7952; Dall'Angelo,
   Sergio/0000-0001-9377-0474; Windhorst, Albert/0000-0002-1250-7656
FU European Union [675417]; British Heart Foundation [PG/16/90/32518];
   Marie Curie Actions (MSCA) [675417] Funding Source: Marie Curie Actions
   (MSCA)
FX We thank the European Union's Horizon 2020 research and innovation
   programme under the Marie Skodowska-Curie grant agreement no. 675417
   (PET3D project) for financial support of the project and the studentship
   of I.P. We also thank the British Heart Foundation for the project grant
   PG/16/90/32518.
CR Alvarez R, 2014, CHEM REV, V114, P1, DOI 10.1021/cr400126u
   Anding AL, 2011, CHEM RES TOXICOL, V24, P1853, DOI 10.1021/tx200174n
   Anzaldi M, 2017, CANCER CHEMOTH PHARM, V79, P725, DOI 10.1007/s00280-017-3265-1
   Aurelio L, 2016, J MED CHEM, V59, P965, DOI 10.1021/acs.jmedchem.5b01439
   Badwin R. M., 1995, NUCL MED BIOL, V22, P659
   Bogni A, 2003, J RADIOANAL NUCL CH, V256, P199, DOI 10.1023/A:1023964712999
   Bonandi E, 2017, DRUG DISCOV TODAY, V22, P1572, DOI 10.1016/j.drudis.2017.05.014
   Campos-Sandoval JA, 2011, J MED CHEM, V54, P4378, DOI 10.1021/jm200256g
   Chen MC, 2014, BIOMEDICINE-TAIWAN, V4, DOI 10.7603/s40681-014-0022-1
   Cingolani F, 2014, J LIPID RES, V55, P1711, DOI 10.1194/jlr.M049759
   Das BC, 2008, BIOORG MED CHEM LETT, V18, P3805, DOI 10.1016/j.bmcl.2008.05.021
   DELIA D, 1993, CANCER RES, V53, P6036
   Dunetz JR, 2016, ORG PROCESS RES DEV, V20, P140, DOI 10.1021/op500305s
   Fawdry RM, 2007, APPL RADIAT ISOTOPES, V65, P1193, DOI 10.1016/j.apradiso.2007.05.011
   Fukumura T, 2004, APPL RADIAT ISOTOPES, V61, P1279, DOI 10.1016/j.apradiso.2004.04.011
   GANIN H, 2012, MEDCHEMCOMM, V4, P175, DOI DOI 10.1039/C2MD20196H
   Geng C, 2017, SCI CHINA LIFE SCI, V60, P1234, DOI [10.1007/s11427-016-9027-6, 10.1007/s11]
   Hail N, 2006, APOPTOSIS, V11, P1677, DOI 10.1007/s10495-006-9289-3
   Hein CD, 2008, PHARM RES-DORDR, V25, P2216, DOI 10.1007/s11095-008-9616-1
   Hill DS, 2009, CLIN CANCER RES, V15, P1192, DOI 10.1158/1078-0432.CCR-08-2150
   Kim HJ, 2006, ONCOGENE, V25, P2785, DOI 10.1038/sj.onc.1209303
   Kraveka JM, 2007, J BIOL CHEM, V282, P16718, DOI 10.1074/jbc.M700647200
   MARIOTTI A, 1994, J NATL CANCER I, V86, P1245, DOI 10.1093/jnci/86.16.1245
   Mcilroy GD, 2016, BIOCHEM PHARMACOL, V100, P86, DOI 10.1016/j.bcp.2015.11.017
   Mcilroy GD, 2013, DIABETES, V62, P825, DOI 10.2337/db12-0458
   Mershon SM, 2007, BIOORG MED CHEM LETT, V17, P836, DOI 10.1016/j.bmcl.2006.10.050
   Mody N, 2014, BIOCHEM PHARMACOL, V91, P277, DOI 10.1016/j.bcp.2014.07.012
   Nieto K, 2018, INT J PHARMACEUT, V538, P48, DOI 10.1016/j.ijpharm.2017.11.037
   Orienti I, 2019, J EXP CLIN CANC RES, V38, DOI 10.1186/s13046-019-1383-9
   Oslowski CM, 2011, METHOD ENZYMOL, V490, P71, DOI 10.1016/B978-0-12-385114-7.00004-0
   Parks BW, 2013, CELL METAB, V17, P141, DOI 10.1016/j.cmet.2012.12.007
   Preitner F, 2009, AM J PHYSIOL-ENDOC M, V297, pE1420, DOI 10.1152/ajpendo.00362.2009
   Rahmaniyan M, 2011, J BIOL CHEM, V286, P24754, DOI 10.1074/jbc.M111.250779
   Sabichi AL, 2003, CLIN CANCER RES, V9, P4606
   SATO M, 1980, BIOCHEM BIOPH RES CO, V95, P1839, DOI 10.1016/S0006-291X(80)80113-6
   Scott PJH, 2009, APPL RADIAT ISOTOPES, V67, P88, DOI 10.1016/j.apradiso.2008.08.015
   SPORN MB, 1976, NATURE, V263, P110, DOI 10.1038/263110a0
   SUZUKI K, 1990, APPL RADIAT ISOTOPES, V41, P593
   Tiberio P, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00226
   Um SJ, 2004, CHEM PHARM BULL, V52, P501, DOI 10.1248/cpb.52.501
   van der Born D, 2017, CHEM SOC REV, V46, P4709, DOI 10.1039/c6cs00492j
   Windhorst A. D., 2001, Journal of Labelled Compounds and Radiopharmaceuticals, V44, pS1052
   Woods M, 2017, EJNMMI RADIOPHARM CH, V2, DOI 10.1186/s41181-017-0032-x
   Zeidan YH, 2007, TRENDS MOL MED, V13, P327, DOI 10.1016/j.molmed.2007.06.002
NR 44
TC 2
Z9 2
U1 0
U2 11
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1860-7179
EI 1860-7187
J9 CHEMMEDCHEM
JI ChemMedChem
PD AUG 19
PY 2020
VL 15
IS 16
BP 1579
EP 1590
DI 10.1002/cmdc.202000143
EA JUL 2020
PG 12
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Pharmacology & Pharmacy
GA NC4SI
UT WOS:000546405300001
PM 32497314
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Meikle, PJ
   Wong, G
   Tan, R
   Giral, P
   Robillard, P
   Orsoni, A
   Hounslow, N
   Magliano, DJ
   Shaw, JE
   Curran, JE
   Blangero, J
   Kingwell, BA
   Chapman, MJ
AF Meikle, Peter J.
   Wong, Gerard
   Tan, Ricardo
   Giral, Philippe
   Robillard, Paul
   Orsoni, Alexina
   Hounslow, Neil
   Magliano, Dianna J.
   Shaw, Jonathan E.
   Curran, Joanne E.
   Blangero, John
   Kingwell, Bronwyn A.
   Chapman, M. John
TI Statin action favors normalization of the plasma lipidome in the
   atherogenic mixed dyslipidemia of MetS: potential relevance to
   statin-associated dysglycemia
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE lipidomics; obesity; plasmalogens; cholesterol; omega-3 fatty acids;
   pitavastatin; metabolic syndrome
ID DENSITY-LIPOPROTEIN; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; DIABETES-MELLITUS; OXIDATIVE STRESS;
   CLINICAL-TRIALS; RISK-FACTORS; CHOLESTEROL; THERAPY
AB The impact of statin treatment on the abnormal plasma lipidome of mixed dyslipidemic patients with metabolic syndrome (MetS), a group at increased risk of developing diabetes, was evaluated. Insulin-resistant hypertriglyceridemic hypertensive obese males (n = 12) displaying MetS were treated with pitavastatin (4 mg/day) for 180 days; healthy normolipidemic age-matched nonobese males (n = 12) acted as controls. Statin treatment substantially normalized triglyceride (-41%), remnant cholesterol (-55%), and LDL-cholesterol (-39%), with minor effect on HDL-cholesterol (+4%). Lipidomic analysis, normalized to nonHDL-cholesterol in order to probe statin-induced differences in molecular composition independently of reduction in plasma cholesterol, revealed increment in 132 of 138 lipid species that were subnormal at baseline and significantly shifted toward the control group on statin treatment. Increment in alkyl- and alkenylphospholipids (plasmalogens) was prominent, and consistent with significant statin-induced increase in plasma polyunsaturated fatty acid levels. Comparison of the statin-mediated lipidomic changes in MetS with the abnormal plasma lipidomic profile characteristic of prediabetes and T2D in the Australian Diabetes, Obesity, and Lifestyle Study and San Antonio Family Heart Study cohorts by hypergeometric analysis revealed a significant shift toward the lipid profile of controls, indicative of a marked trend toward a normolipidemic phenotype. Pitavastatin attenuated the abnormal plasma lipidome of MetS patients typical of prediabetes and T2D.
C1 [Meikle, Peter J.; Wong, Gerard; Tan, Ricardo; Magliano, Dianna J.; Shaw, Jonathan E.; Kingwell, Bronwyn A.] Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia.
   [Giral, Philippe; Robillard, Paul; Orsoni, Alexina; Chapman, M. John] Pitie Salpetriere Univ Hosp, Dyslipidemia & Atherosclerosis Res Unit, INSERM UMR S939, Paris, France.
   [Giral, Philippe; Robillard, Paul; Orsoni, Alexina; Chapman, M. John] Univ Paris 06, Pitie Salpetriere Univ Hosp, Paris, France.
   [Hounslow, Neil] Kowa Res Europe Ltd, Wokingham, Berks, England.
   [Curran, Joanne E.; Blangero, John] Univ Texas Hlth Sci Ctr San Antonio, South Texas Diabet & Obes Inst, Harlingen, TX USA.
C3 Baker Heart and Diabetes Institute; Institut National de la Sante et de
   la Recherche Medicale (Inserm); Sorbonne Universite; Assistance Publique
   Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP;
   Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Pitie-Salpetriere - APHP; Sorbonne Universite; University of Texas
   System; University of Texas Health Science Center at San Antonio
RP Meikle, PJ (corresponding author), Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia.
EM peter.meikle@bakeridi.edu.au
RI Blangero, John/ABA-7175-2021; Hounslow, Neil/GQA-9028-2022; Meikle,
   Peter/B-4023-2009; chapman, john/Y-2742-2019; Kingwell,
   Bronwyn/B-1183-2009; ORSONI, Alexina/C-6740-2009
OI ORSONI, Alexina/0000-0003-4250-6280; Kingwell,
   Bronwyn/0000-0002-2162-0458; Hounslow, Neil/0000-0002-9821-4941; Curran,
   Joanne/0000-0002-6898-155X; Magliano, Dianna/0000-0002-9507-6096;
   Meikle, Peter/0000-0002-2593-4665; Blangero, John/0000-0001-6250-5723
FU Kowa Research Europe; INSERM; Nouvelle Societe Francaise
   d'Atherosclerose (NSFA); Association for Research on Lipoproteins and
   Atherogenesis (ARLA); National Health and Medical Research Council of
   Australia; OIS Program of the Victorian Government, Australia; National
   Institute of Diabetes and Digestive and Kidney Diseases, National
   Institutes of Health, Bethesda, MD [1R01DK088972-01]; NHMRC Senior
   Research Fellowships; NHMRC Senior Principal Research Fellowship
FX The authors are indebted to Kowa Research Europe for the award of a
   clinical research grant to support all aspects of the CAPITAIN study and
   lipidomic analyses (ClinicalTrials.gov: NCT01595828), and to INSERM, the
   Nouvelle Societe Francaise d'Atherosclerose (NSFA), and the Association
   for Research on Lipoproteins and Atherogenesis (ARLA) for additional
   support. This work was equally supported by funding from the National
   Health and Medical Research Council of Australia, the OIS Program of the
   Victorian Government, Australia, and by award number 1R01DK088972-01
   from the National Institute of Diabetes and Digestive and Kidney
   Diseases, National Institutes of Health, Bethesda, MD. P.J.M. and J.E.S.
   are supported by NHMRC Senior Research Fellowships and B.A.K. by a NHMRC
   Senior Principal Research Fellowship. The content of this work is solely
   the responsibility of the authors and does not necessarily represent the
   official views of the aforementioned funding bodies. The authors take
   full responsibility for the content of this manuscript.
CR Alberti G, 2006, IDF COMMUNICATIONS
   Baigent C, 2010, LANCET, V376, P1670, DOI 10.1016/S0140-6736(10)61350-5
   Barter PJ, 2010, J LIPID RES, V51, P1546, DOI 10.1194/jlr.P002816
   Boon J, 2013, DIABETES, V62, P401, DOI 10.2337/db12-0686
   Cederberg H, 2015, DIABETOLOGIA, V58, P1109, DOI 10.1007/s00125-015-3528-5
   Chapman MJ, 2014, CURR MED RES OPIN, V30, P775, DOI 10.1185/03007995.2013.874989
   Chapman MJ, 2011, EUR HEART J, V32, P1345, DOI 10.1093/eurheartj/ehr112
   Chapman MJ, 2010, EUR HEART J, V31, P149, DOI 10.1093/eurheartj/ehp399
   de Mello VDF, 2009, DIABETOLOGIA, V52, P2612, DOI 10.1007/s00125-009-1482-9
   Demetz E, 2014, CELL METAB, V20, P787, DOI 10.1016/j.cmet.2014.09.004
   Dunstan DW, 2002, DIABETES RES CLIN PR, V57, P119, DOI 10.1016/S0168-8227(02)00025-6
   Fournier N, 1997, ARTERIOSCL THROM VAS, V17, P2685, DOI 10.1161/01.ATV.17.11.2685
   Gayoso-Diz P, 2013, BMC ENDOCR DISORD, V13, DOI 10.1186/1472-6823-13-47
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   JURGENS G, 1995, CHEM PHYS LIPIDS, V77, P25, DOI 10.1016/0009-3084(95)02451-N
   Kashani A, 2006, CIRCULATION, V114, P2788, DOI 10.1161/CIRCULATIONAHA.106.624890
   Kontush A, 2003, ARTERIOSCL THROM VAS, V23, P1881, DOI 10.1161/01.ATV.0000091338.93223.E8
   Kontush A, 2007, ARTERIOSCL THROM VAS, V27, P1843, DOI 10.1161/ATVBAHA.107.145672
   Li NS, 2014, ATHEROSCLEROSIS, V233, P130, DOI 10.1016/j.atherosclerosis.2013.12.013
   Mankidy R, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-62
   Marigny K, 2002, ACTA PHYSIOL SCAND, V176, P263, DOI 10.1046/j.1365-201X.2002.01037.x
   Meikle PJ, 2014, PHARMACOL THERAPEUT, V143, P12, DOI 10.1016/j.pharmthera.2014.02.001
   Meikle PJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0074341
   Meikle PJ, 2011, ARTERIOSCL THROM VAS, V31, P2723, DOI 10.1161/ATVBAHA.111.234096
   Mitchell BD, 1996, CIRCULATION, V94, P2159, DOI 10.1161/01.CIR.94.9.2159
   Naci H, 2013, CIRC-CARDIOVASC QUAL, V6, P390, DOI 10.1161/CIRCOUTCOMES.111.000071
   Navarese EP, 2013, AM J CARDIOL, V111, P1123, DOI 10.1016/j.amjcard.2012.12.037
   Nelson J, 2006, AM J EPIDEMIOL, V163, P903, DOI 10.1093/aje/kwj140
   Nicholls SJ, 2011, NEW ENGL J MED, V365, P2078, DOI 10.1056/NEJMoa1110874
   Pynn CJ, 2011, J LIPID RES, V52, P399, DOI 10.1194/jlr.d011916
   Reiner Z, 2011, EUR HEART J, V32, P1769, DOI [10.1016/j.atherosclerosis.2011.06.012, 10.1093/eurheartj/ehr158]
   Ridker PM, 2012, LANCET, V380, P565, DOI 10.1016/S0140-6736(12)61190-8
   Sattar NA, 2014, ATHEROSCLEROSIS SUPP, V15, P1, DOI 10.1016/j.atherosclerosissup.2014.04.001
   Sposito AC, 2002, ARTERIOSCL THROM VAS, V22, P1524, DOI 10.1161/01.ATV.0000032033.39301.6A
   Swerdlow DI, 2015, LANCET, V385, P351, DOI 10.1016/S0140-6736(14)61183-1
   Vallejo-Vaz AJ, 2015, ATHEROSCLEROSIS, V241, P409, DOI 10.1016/j.atherosclerosis.2015.06.001
   Vance DE, 2013, BBA-MOL CELL BIOL L, V1831, P626, DOI 10.1016/j.bbalip.2012.07.017
   Waters DD, 2013, J AM COLL CARDIOL, V61, P148, DOI 10.1016/j.jacc.2012.09.042
   Weir JM, 2013, J LIPID RES, V54, P2898, DOI 10.1194/jlr.P035808
   Würtz P, 2015, CIRCULATION, V131, P774, DOI 10.1161/CIRCULATIONAHA.114.013116
   Zerrad-Saadi A, 2009, ARTERIOSCL THROM VAS, V29, P2169, DOI 10.1161/ATVBAHA.109.194555
NR 41
TC 46
Z9 48
U1 1
U2 14
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD DEC
PY 2015
VL 56
IS 12
BP 2381
EP 2392
DI 10.1194/jlr.P061143
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CX6XA
UT WOS:000365843800014
PM 26486974
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Siqueira, FJWS
   Rodrigues, FAP
   Ribeiro, SA
   Veras, HN
   Ferreira, FCS
   Siqueira, RCL
   dos Santos, AA
   Havt, A
   Lima, AAM
AF Siqueira, F. J. W. S.
   Rodrigues, F. A. P.
   Ribeiro, S. A.
   Veras, H. N.
   Ferreira, F. C. S.
   Siqueira, R. C. L.
   dos Santos, A. A.
   Havt, A.
   Lima, A. A. M.
TI Induced acute hyperglycemia modifies the barrier function of the
   intestinal epithelium by tissue inflammation and tight junction
   disruption resulting in hydroelectrolytic secretion in an animal model
SO BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
LA English
DT Article
DE Diabetic metabolic syndrome; Intestinal epithelium barrier function;
   Tight junctions; Oxidative damage; Ion and; water intestinal transports
ID METABOLIC SYNDROME; TRANSPORT; CHILDREN
AB Diabetic-metabolic syndrome (MetS-D) has a high prevalence worldwide, in which an association with the rupture of the intestinal epithelium barrier function (IEBF) has been pointed out, but the functional and morphological properties are still not well understood. This study aimed to evaluate the impact of acute hyperglycemia diabetes on intestinal tight junction proteins, metabolic failure, intestinal ion and water transports, and IEBF parameters. Diabetes was induced in male Rattus norvegicus (200-310 g) with 0.5 mL of streptozotocin (70 mg/kg). Glycemic and clinical parameters were evaluated every 7 days, and intestinal parameters were evaluated on the 14th day. The MetS-D animals showed a clinical pattern of hyperglycemia, with increases in the area of villi and crypts, lactulose:mannitol ratio, myeloperoxidase (MPO) activity, and intestinal tissue concentrations of malondialdehyde (MDA), but showed a reduction in reduced glutathione (GSH) when these parameters were compared to the control. The MetS-D group had increased secretion of Na+, K+, Cl-, and water compared to the control group in ileal tissue. Furthermore, we observed a reduction in mRNA transcript of claudin-2, claudin-15, and NHE3 and increases of SGLT-1 and ZO-1 in the MetS-D group. These results showed that MetS-D triggered intestinal tissue inflammation, oxidative stress, complex alterations in gene regulatory protein transcriptions of intestinal transporters and tight junctions, damaging the IEBF and causing hydroelectrolyte secretion.
C1 [Siqueira, F. J. W. S.; Veras, H. N.; Ferreira, F. C. S.; Siqueira, R. C. L.; dos Santos, A. A.; Havt, A.; Lima, A. A. M.] Univ Fed Ceara, Fac Med, Dept Fisiol & Farmacol, Fortaleza, CE, Brazil.
   [Rodrigues, F. A. P.] Inst Fed Educ Ciencia & Tecnol Ceara, Dept Educ Fis & Esporte, Fortaleza, CE, Brazil.
   [Ribeiro, S. A.] Univ Fed Ceara, Fac Med, Dept Patol & Med Legal, Programa Posgrad Ciencias Med, Fortaleza, CE, Brazil.
C3 Universidade Federal do Ceara; Instituto Federal do Ceara (IFCE);
   Universidade Federal do Ceara
RP Lima, AAM (corresponding author), Univ Fed Ceara, Fac Med, Dept Fisiol & Farmacol, Fortaleza, CE, Brazil.
EM alima@ufc.br
RI de Paulo Rodrigues, Francisco/ABI-3860-2020; Havt,
   Alexandre/AAM-8585-2020; LIMA, ALDO/D-8251-2018
OI Havt, Alexandre/0000-0002-4546-2976; Rodrigues, Francisco Adelvane de
   Paulo/0000-0001-9890-4232; LIMA, ALDO/0000-0002-0299-1747; Silva
   Ferreira, Francisco Cleber/0000-0002-9501-870X; Aguiar dos Santos,
   Armenio/0000-0003-0912-3720; SIQUEIRA, ROMMULO CELLY
   LIMA/0000-0003-0533-9305
FU National Council for Scientific and Technological Development (CNPq);
   Coordination for the Improvement of Higher Education Personnel (CAPES);
   Cearense Foundation for Scientific and Technological Development
   (FUNCAp) [03041300/2021]
FX We thank the funding agencies National Council for Scientific and
   Technological Development (CNPq) , Coordination for the Improvement of
   Higher Education Personnel (CAPES) , and Cearense Foundation for
   Scientific and Technological Development (FUNCAp, No. 03041300/2021) .
CR Aleman RS, 2023, MOLECULES, V28, DOI 10.3390/molecules28020619
   da Silva ACA, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.734038
   Barboza MS, 1999, BRAZ J MED BIOL RES, V32, P1499, DOI 10.1590/S0100-879X1999001200008
   Pereira JNB, 2021, PHYSIOL REP, V9, DOI 10.14814/phy2.14755
   Cabrera SM, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-07203-6
   Chillarón JJ, 2010, REV ESP CARDIOL, V63, P423, DOI 10.1016/S1885-5857(10)70091-8
   Choromanska B, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/1057570
   Dandare SU, 2021, J FOOD BIOCHEM, V45, DOI 10.1111/jfbc.13590
   de Castro VMD, 2021, TISSUE CELL, V69, DOI 10.1016/j.tice.2020.101483
   Di Tommaso N, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph182312836
   He PJ, 2015, J CLIN INVEST, V125, P3519, DOI 10.1172/JCI79552
   Kennard MR, 2021, DIABETIC MED, V38, DOI 10.1111/dme.14705
   Kopic S, 2010, TOXINS, V2, P2132, DOI 10.3390/toxins2082132
   Korac B, 2021, REDOX BIOL, V42, DOI 10.1016/j.redox.2021.101887
   Lee YN, 2021, CLIN MED, V21, pE337, DOI 10.7861/clinmed.2021-0369
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   Malik A, 2018, EUR J CLIN INVEST, V48, DOI 10.1111/eci.13021
   Menini S, 2021, CANCERS, V13, DOI 10.3390/cancers13020313
   Monsted MO, 2021, J AUTOIMMUN, V122, DOI 10.1016/j.jaut.2021.102674
   Mourad Fadi H., 2004, Journal of Pharmacological and Toxicological Methods, V50, P3, DOI 10.1016/j.vascn.2003.12.003
   Musso G, 2019, BMJ-BRIT MED J, V365, DOI 10.1136/bmj.l1328
   Ochocinska A, 2022, NUTRIENTS, V14, DOI 10.3390/nu14030414
   Okun JG, 2021, NAT METAB, V3, P394, DOI 10.1038/s42255-021-00369-9
   Oresic M, 2008, J EXP MED, V205, P2975, DOI 10.1084/jem.20081800
   Portincasa P, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10010083
   Raju P, 2020, J CLIN INVEST, V130, P5197, DOI 10.1172/JCI138697
   Rouland M, 2022, GUT, V71, P296, DOI 10.1136/gutjnl-2020-323664
   Sawasvirojwong S, 2013, PLOS NEGLECT TROP D, V7, DOI 10.1371/journal.pntd.0002293
   Schork A, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0852-y
   Selby A, 2019, DIGEST DIS SCI, V64, P3385, DOI 10.1007/s10620-019-05846-6
   Sorini C, 2019, P NATL ACAD SCI USA, V116, P15140, DOI 10.1073/pnas.1814558116
   Subramanya SB, 2007, AM J PHYSIOL-GASTR L, V293, pG857, DOI 10.1152/ajpgi.00462.2006
   Turner JR, 2009, NAT REV IMMUNOL, V9, P799, DOI 10.1038/nri2653
   Vrdoljak J, 2022, NUTRIENTS, V14, DOI 10.3390/nu14030456
   Wada M, 2013, GASTROENTEROLOGY, V144, P369, DOI 10.1053/j.gastro.2012.10.035
   Wang L, 2020, J FUNCT FOODS, V64, DOI 10.1016/j.jff.2019.103614
   Weber CR, 2015, ELIFE, V4, DOI 10.7554/eLife.09906
   Wu JZ, 2015, DIABET METAB SYND OB, V8, P181, DOI 10.2147/DMSO.S82272
   Zeng Z, 2020, MOL MED REP, V22, P1892, DOI 10.3892/mmr.2020.11270
   Zhao W, 2017, NAT GENET, V49, P1450, DOI 10.1038/ng.3943
NR 40
TC 2
Z9 2
U1 3
U2 3
PU ASSOC BRAS DIVULG CIENTIFICA
PI RIBEIRAO PRETO
PA FACULDADE MEDICINA, CASA 10, 14049 RIBEIRAO PRETO, RIBEIRAO PRETO, SP
   14049, BRAZIL
SN 0100-879X
EI 1414-431X
J9 BRAZ J MED BIOL RES
JI Brazilian J. Med. Biol. Res.
PY 2024
VL 57
AR e13309
DI 10.1590/1414-431X2024e13309
PG 13
WC Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Research & Experimental
   Medicine
GA PZ3V8
UT WOS:001217870200001
PM 38656073
OA gold
DA 2025-06-11
ER

PT J
AU Mahjoub, SK
   Ahmad, MAAS
   Kamel, FO
   Alseini, M
   Khan, LM
AF Mahjoub, S. K.
   Ahmad, M. A. A. Sattar
   Kamel, F. O.
   Alseini, M.
   Khan, L. M.
TI Preclinical study of vitamin D deficiency in the pathogenesis of
   metabolic syndrome in rats
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Vitamin D deficiency; Metabolic syndrome; Interleuk-ine; Homeostasis
   model assessment for insulin resistance index; Nuclear factor kappa beta
ID CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; INDUCED HYPERTENSION;
   OXIDATIVE STRESS; RISK; ASSOCIATION; CALCIUM; GLUCOSE; OBESITY; ALPHA
AB OBJECTIVE: To explore the im-pact of vitamin D deficiency (VD-) in the patho-genesis of metabolic syndrome (MetS). MATERIALS AND METHODS: Models of (VD-) and (MetS) were induced in male Wister rats by dividing into four groups, group-I for the develop-ment of (VD-) by intraperitoneal injection of pari-calcitol for 3 weeks, group II for (MetS) model by adding 10% fructose to their drinking water for 8 weeks, the group III for induction of combined (VD-+ MetS) and group-IV as a control. Ultimately, the parameters of (VD-) and (MetS) were assessed at zero time and after 8 weeks. RESULTS: Both (VD-) and (MetS) groups alone displayed a remarkable enhancement of blood pressure, glucose and insulin levels, tri-glycerides, cholesterol, and low-density lipopro-teins with a reduction of high-density lipopro-teins. Additionally, all distinguishing features of obesity were substantially increased. Neverthe-less, the combined group (VD-+MetS) demon-strated an expeditious and substantial increase in all the aforesaid parameters compared to the (VD-) and (MetS) groups alone. CONCLUSIONS: The hallmark of this study, reinforces a new frontier of awareness of the deleterious effect of (VD-) on each component of (MetS). Eventually, supplementation of vita-min D can circumvent the elements of (MetS) and needs further validation by determination of (VD-) molecular pathway on the parameters of (MetS).
C1 [Mahjoub, S. K.] King Fahad Gen Hosp, Minist Hlth, Jeddah, Saudi Arabia.
   [Ahmad, M. A. A. Sattar; Kamel, F. O.; Alseini, M.; Khan, L. M.] King Abdulaziz Univ, Fac Med, Dept Pharmacol, Jeddah, Saudi Arabia.
C3 Ministry of Health - Saudi Arabia; King Fahd Hospital Jeddah; King
   Abdulaziz University
RP Khan, LM (corresponding author), King Abdulaziz Univ, Fac Med, Dept Pharmacol, Jeddah, Saudi Arabia.
EM lmkhan@kau.edu.sa
RI Kamel, Fatemah/HLH-3014-2023; Khan, Lateef/J-7827-2012
OI Khan, Lateef/0000-0002-3728-7717
FU King Abdulaziz City for Science and Technology [IT-1979-38]
FX Thanks to King Abdulaziz City for Science and Technology for its
   financial support for the project of the research number (IT-1979-38).
CR Aankur Garg Aankur Garg, 2014, International Journal of Phytomedicine, V6, P433
   Aggarwal N, 2010, CURR CARDIOVASC RISK, V4, P68, DOI 10.1007/s12170-009-0072-1
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   [Anonymous], 2013, J Phys Pharm Adv, DOI [10.5455/jppa.20130317071355, DOI 10.5455/JPPA.20130317071355]
   Argacha JF, 2011, J CARDIOVASC PHARM, V58, P65, DOI 10.1097/FJC.0b013e31821c832f
   Bellia A, 2013, INTERN EMERG MED, V8, P33, DOI 10.1007/s11739-011-0559-x
   Botella-Carretero JI, 2007, CLIN NUTR, V26, P573, DOI 10.1016/j.clnu.2007.05.009
   Brandenburg VM, 2012, ATHEROSCLEROSIS, V225, P253, DOI 10.1016/j.atherosclerosis.2012.08.005
   Chang KC, 2007, BRIT J PHARMACOL, V151, P341, DOI 10.1038/sj.bjp.0707223
   Cheng S, 2010, DIABETES, V59, P242, DOI 10.2337/db09-1011
   Cohen-Lahav M, 2006, NEPHROL DIAL TRANSPL, V21, P889, DOI 10.1093/ndt/gfi254
   DAI S, 1995, J PHARMACOL TOX MET, V33, P101, DOI 10.1016/1056-8719(94)00063-A
   Daniele G, 2014, ACTA DIABETOL, V51, P123, DOI 10.1007/s00592-013-0543-1
   Daugherty Alan, 2009, J Vis Exp, DOI 10.3791/1291
   Dong JH, 2012, EUR HEART J, V33, P2980, DOI 10.1093/eurheartj/ehr459
   Forouhi NG, 2008, DIABETES, V57, P2619, DOI 10.2337/db08-0593
   Garg A., 2015, Int. J. Pharm. Pharm. Sci, V7, P237, DOI [10.22159/ijpps.2015v7i4.4275, DOI 10.22159/IJPPS.2015V7I4.4275]
   Gradinaru D, 2012, AGING CLIN EXP RES, V24, P595, DOI 10.3275/8591
   Grundmann M, 2012, AM J PHYSIOL-CELL PH, V303, pC954, DOI 10.1152/ajpcell.00030.2012
   Guasch A, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-149
   Judd SE, 2009, AM J MED SCI, V338, P40, DOI 10.1097/MAJ.0b013e3181aaee91
   KADOWAKI S, 1984, ARCH BIOCHEM BIOPHYS, V233, P228, DOI 10.1016/0003-9861(84)90621-0
   Kamycheva E, 2007, J ENDOCRINOL INVEST, V30, P126, DOI 10.1007/BF03347410
   Karpe F, 2011, DIABETES, V60, P2441, DOI 10.2337/db11-0425
   Kassi E, 2013, CIRCULATION, V128, P2517, DOI 10.1161/CIRCULATIONAHA.113.002654
   Kato S, 2000, J BIOCHEM, V127, P717, DOI 10.1093/oxfordjournals.jbchem.a022662
   Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2548, DOI 10.1210/jc.2004-0395
   Labudzynskyi D O, 2015, Ukr Biochem J, V87, P75
   Lavie CJ, 2011, J AM COLL CARDIOL, V58, P1547, DOI 10.1016/j.jacc.2011.07.008
   Levin A, 2005, KIDNEY INT, V68, P1973, DOI 10.1111/j.1523-1755.2005.00651.x
   Liamis G, 2014, WORLD J CLIN CASES, V2, P488, DOI 10.12998/wjcc.v2.i10.488
   Liamis G, 2013, AM J MED, V126, P256, DOI 10.1016/j.amjmed.2012.06.037
   Makariou S, 2011, EUR J INTERN MED, V22, P355, DOI 10.1016/j.ejim.2011.04.012
   Mandarino Natalia Ribeiro, 2015, Open Cardiovasc Med J, V9, P40, DOI 10.2174/1874192401509010040
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Miñambres I, 2015, CLIN LIPIDOL, V10, P513, DOI 10.2217/clp.15.38
   Mitri J, 2014, ENDOCRIN METAB CLIN, V43, P205, DOI 10.1016/j.ecl.2013.09.010
   Molinari C, 2011, CELL PHYSIOL BIOCHEM, V27, P661, DOI 10.1159/000330075
   Muscogiuri G, 2017, INT J CARDIOL, V230, P577, DOI 10.1016/j.ijcard.2016.12.053
   Ning CH, 2015, LIPIDS HEALTH DIS, V14, DOI 10.1186/s12944-015-0030-5
   Osadnik K, 2020, DIABET METAB SYND OB, V13, P1281, DOI 10.2147/DMSO.S232497
   Palomer X, 2008, DIABETES OBES METAB, V10, P185, DOI 10.1111/j.1463-1326.2007.00710.x
   Park JE, 2018, J OBES METAB SYNDR, V27, P223, DOI 10.7570/jomes.2018.27.4.223
   Patel J, 2009, INDIAN J BIOCHEM BIO, V46, P66
   Pereira-Santos M, 2015, OBES REV, V16, P341, DOI 10.1111/obr.12239
   Pittas AG, 2012, DIABETES CARE, V35, P565, DOI 10.2337/dc11-1795
   SCHEDL HP, 1978, ENDOCRINOLOGY, V103, P1368, DOI 10.1210/endo-103-4-1368
   Sergeev IN, 2016, HORM MOL BIOL CLIN I, V26, P61, DOI 10.1515/hmbci-2015-0069
   Sooy K, 1999, J BIOL CHEM, V274, P34343, DOI 10.1074/jbc.274.48.34343
   Stavenuiter A., 2015, BIOMED RES INT, V2015, P1
   Tare M, 2011, J PHYSIOL-LONDON, V589, P4777, DOI 10.1113/jphysiol.2011.214726
   Wang HM, 2017, AGING DIS, V8, P346, DOI 10.14336/AD.2016.1021
   WEISHAAR RE, 1987, J CLIN INVEST, V79, P1706, DOI 10.1172/JCI113010
   WHITE JR, 1993, ANN PHARMACOTHER, V27, P775, DOI 10.1177/106002809302700619
   Widdop RE, 1997, CLIN SCI, V93, P191, DOI 10.1042/cs0930191
   Wimalawansa SJ, 2018, J STEROID BIOCHEM, V175, P177, DOI 10.1016/j.jsbmb.2016.09.017
   Wong MSK, 2008, AM J PHYSIOL-HEART C, V295, pH289, DOI 10.1152/ajpheart.00116.2008
   Young KA, 2009, J CLIN ENDOCR METAB, V94, P3306, DOI 10.1210/jc.2009-0079
NR 58
TC 1
Z9 1
U1 0
U2 1
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PY 2022
VL 26
IS 23
BP 9001
EP 9014
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 9M9VM
UT WOS:000942569200014
PM 36524519
DA 2025-06-11
ER

PT J
AU Anand, C
   Singh, R
   Narayana, S
AF Anand, Chandrika
   Singh, Rakhi
   Narayana, S.
TI Assessment of metabolic risk among the Rotterdam's polycystic ovary
   syndrome phenotypes in Bangalore
SO JOURNAL OF KRISHNA INSTITUTE OF MEDICAL SCIENCES UNIVERSITY
LA English
DT Article
DE Polycystic Ovary Syndrome; Phenotypes; Metabolic syndrome;
   Hyperandrogenism; Irregular; menstruation
ID WOMEN; PROFILE
AB Background: Polycystic Ovary Syndrome (PCOS) is characterized by a variety of complex manifestations with an unclear underlying cause. This condition is consistently linked to an increased cardio-metabolic risk. It is essential to evaluate this risk at the phenotype level to identify the most vulnerable subgroup within the PCOS population. Aim and Objectives: To phenotype the PCOS patients as per the standard Rotterdam's criteria and to assess the metabolic syndrome markers in those phenotypes. Material and Methods: A total of seven hundred participants (n=700) were assessed and categorized based on the Rotterdam criteria. Clinical, radiological, and biochemical assessments were conducted and analyzed statistically. Chi-square and two-way ANOVA tests were conducted using SPSS version 19 statistical software. The results indicated that phenotype A was the most prevalent, comprising 83.2% (583) of the cases, followed by phenotype C at 8% (56), phenotype D at 5.55% (39), and phenotype B at 3.1% (22). Notably, phenotype B, while being the least prevalent, exhibited the highest metabolic risk. This phenotype was significantly associated with increased levels of hirsutism, postprandial hyperinsulinemia, impaired glucose tolerance, and hormonal imbalances. Additionally, although not statistically significant, there was a higher occurrence of family history of metabolic syndrome, elevated waist circumference (greater than 35 inches), obesity, stress, and dyslipidemia associated with this phenotype. Conclusion: The highest metabolic risk was observed in phenotype B, which was characterized by a combination of hyperandrogenism and irregular menstruation in the absence of polycystic ovaries.
C1 [Anand, Chandrika] PCOS Ctr, Dept Gynecol & Obstet, Saraswathi Special Clin, Bangalore 560072, Karnataka, India.
   [Singh, Rakhi] Abalone Clin, Dept Gynecol & Obstet, Matern & Fertil Ctr, Noida 201301, Uttar Pradesh, India.
   [Narayana, S.] Padmashree Inst Med Lab Technol, Dept Biochem, Bangalore 560060, Karnataka, India.
RP Narayana, S (corresponding author), Padmashree Inst Med Lab Technol, Dept Biochem, Bangalore 560060, Karnataka, India.
EM narayan.s201991@gmail.com
CR AbdulAzeez IM, 2018, J KRISHNA INST MED S, V7, P62
   Bahadur A, 2021, GYNECOL ENDOCRINOL, V37, P21, DOI 10.1080/09513590.2020.1775193
   Bernardis E, 2020, JAMA DERMATOL, V156, P296, DOI 10.1001/jamadermatol.2019.4668
   Bharali MD, 2022, CUREUS J MED SCIENCE, V14, DOI 10.7759/cureus.32351
   Bil E, 2016, J OBSTET GYNAECOL RE, V42, P837, DOI 10.1111/jog.12985
   Darchini-Maragheh E, 2024, CLIN EXP DERMATOL, V50, P267, DOI 10.1093/ced/llae320
   Deswal Ritu, 2020, J Hum Reprod Sci, V13, P261, DOI 10.4103/jhrs.JHRS_95_18
   Elasam AN, 2022, BMC WOMENS HEALTH, V22, DOI 10.1186/s12905-022-01762-6
   Gibson-Helm M, 2017, J CLIN ENDOCR METAB, V102, P604, DOI 10.1210/jc.2016-2963
   Gluszak O, 2012, ISRN Endocrinol
   González-Saldivar G, 2018, DERM-ENDOCRINOL, V10, DOI 10.1080/19381980.2018.1471958
   Kahraman Filiz Cebeci, 2022, Postepy Dermatol Alergol, V39, P744, DOI 10.5114/ada.2021.108455
   Kamrul-Hasan A.B.M., 2023, Endocr. Metab. Sci, V14, DOI [10.1016/j.endmts.2023.100153, DOI 10.1016/J.ENDMTS.2023.100153]
   Khan B, 2022, Int J Rep Contra Obst Gynecol, V11, P765
   Kudugunti N, 2021, J KRISHNA INST MED S, V10, P100
   Lizneva D, 2016, FERTIL STERIL, V106, P1510, DOI 10.1016/j.fertnstert.2016.07.1121
   Malini NA, 2021, ACTA ENDOCRINOL-BUCH, V17, P313, DOI 10.4183/aeb.2021.313
   Melo AS, 2015, CLINICS, V70, P765
   Mitra S, 2024, ANN ENDOCRINOL-PARIS, V85, P44, DOI 10.1016/j.ando.2023.06.001
   Mitrasinovic-Brulic M, 2021, MIDDLE EAST FERTIL S, V26, DOI 10.1186/s43043-021-00085-0
   Mumusoglu S., 2020, Curr Opin Endocr Metab Res, V12, P66, DOI [DOI 10.1016/J.COEMR.2020.03.004, 10.1016/j.coemr.2020.03.004, 10.1016/J.COEMR.2020.03.004]
   Ozlu E, 2018, NORTH CLIN ISTANB, V5, P114, DOI 10.14744/nci.2017.68553
   Sachdeva Garima, 2019, Indian J Endocrinol Metab, V23, P326, DOI 10.4103/ijem.IJEM_30_19
   Smid CJ, 2018, AM J MED GENET A, V176, P2630, DOI 10.1002/ajmg.a.40506
   Soares JM Jr, 2023, BIOMEDICINES, V11, DOI 10.3390/biomedicines11123262
   Solorzano CMB, 2018, J CLIN ENDOCR METAB, V103, P2571, DOI 10.1210/jc.2018-00131
   Spritzer PM, 2022, DIAGNOSTICS, V12, DOI 10.3390/diagnostics12081922
   Tavares A, 2019, REV BRAS GINECOL OBS, V41, P37, DOI 10.1055/s-0038-1676568
   Tripathy P, 2018, EUR J OBSTET GYN R B, V224, P60, DOI 10.1016/j.ejogrb.2018.02.031
   Wekker V, 2020, HUM REPROD UPDATE, V26, P942, DOI 10.1093/humupd/dmaa029
NR 30
TC 0
Z9 0
U1 0
U2 0
PU KRISHNA INST MEDICAL SCIENCES UNIV
PI MAHARASHTRA
PA MALKAPUR, KARAD, MAHARASHTRA, 415 539, INDIA
SN 2231-4261
J9 J KRISHNA INST MED S
JI J. Krishna Inst. Med. Sci. Univ.
PD OCT-DEC
PY 2024
VL 13
IS 4
BP 159
EP 167
PG 9
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA 1ID0Z
UT WOS:001465574100016
DA 2025-06-11
ER

PT J
AU Grzesiak, K
   Ryl, A
   Stachowska, E
   Slojewski, M
   Rotter, I
   Ratajczak, W
   Sipak, O
   Piasecka, M
   Dolegowska, B
   Laszczynska, M
AF Grzesiak, Katarzyna
   Ryl, Aleksandra
   Stachowska, Ewa
   Slojewski, Marcin
   Rotter, Iwona
   Ratajczak, Weronika
   Sipak, Olimpia
   Piasecka, Malgorzata
   Dolegowska, Barbara
   Laszczynska, Maria
TI The Relationship between Eicosanoid Levels and Serum Levels of Metabolic
   and Hormonal Parameters Depending on the Presence of Metabolic Syndrome
   in Patients with Benign Prostatic Hyperplasia
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE metabolic syndrome; benign prostatic hyperplasia; fatty acids
ID ARACHIDONIC-ACID; HYDROXYOCTADECADIENOIC ACIDS; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; LINOLEIC-ACID; FATTY-ACIDS; CANCER; ASSOCIATION;
   EXPRESSION; 12-LIPOXYGENASE
AB Background: The purpose of our investigation was to analyze the relationship between the serum levels of inflammatory mediators (HETE, HODE) and the levels of selected metabolic and hormonal parameters in patients with benign prostatic hyperplasia (BPH) with regard to concomitant metabolic syndrome (MetS). Methods: The study involved 151 men with BPH. Blood samples were taken for laboratory analysis of the serum levels of metabolic and hormonal parameters. Gas chromatography was performed using an Agilent Technologies 7890A GC System. Results: We found that waist circumference was the only parameter related to the levels of fatty acids, namely: 13(S)-HODE, 9(S)-HODE, 15(S)-HETE, 12(S)-HETE, and 5-HETE. In the patients with BPH and MetS, triglycerides correlated with 9(S)-HODE, 15(S)-HETE, 12(S)-HETE, and 5-HETE, which was not observed in the patients without MetS. Similarly, total cholesterol correlated with 9(S)-HODE, and 15(S)-HETE in the patients with BPH and MetS, but not in those without MetS. In the group of BPH patients with MetS, total testosterone positively correlated with 13(S)-HODE, and free testosterone with 9(S)-HODE. Conclusions: Based on this study, it can be concluded that lipid mediators of inflammation can influence the levels of biochemical and hormonal parameters, depending on the presence of MetS in BPH patients.
C1 [Grzesiak, Katarzyna; Ratajczak, Weronika; Piasecka, Malgorzata; Laszczynska, Maria] Pomeranian Med Univ, Dept Histol & Dev Biol, Zolnierska 48, PL-71210 Szczecin, Poland.
   [Ryl, Aleksandra; Rotter, Iwona] Pomeranian Med Univ, Dept Med Rehabil & Clin Physiotherapy, Zolnierska 48, PL-71210 Szczecin, Poland.
   [Stachowska, Ewa] Pomeranian Med Univ, Dept Biochem & Human Nutr, Broniewskiego 24, PL-71460 Szczecin, Poland.
   [Slojewski, Marcin] Pomeranian Med Univ, Dept Urol & Urol Oncol, Powstancow Wlkp 72, PL-70111 Szczecin, Poland.
   [Sipak, Olimpia] Pomeranian Med Univ, Dept Obstet & Pathol Pregnancy, Zolnierska 48, PL-71210 Szczecin, Poland.
   [Dolegowska, Barbara] Pomeranian Med Univ, Dept Microbiol Immunol & Lab Med, Powstancow Wlkp 72, PL-70111 Szczecin, Poland.
C3 Pomeranian Medical University; Pomeranian Medical University; Pomeranian
   Medical University; Pomeranian Medical University; Pomeranian Medical
   University; Pomeranian Medical University
RP Ryl, A (corresponding author), Pomeranian Med Univ, Dept Med Rehabil & Clin Physiotherapy, Zolnierska 48, PL-71210 Szczecin, Poland.
EM kasia.grzesiak302@gmail.com; aleksandra.ryl@pum.edu.pl;
   ewast@pum.edu.pl; mslojewski@gmail.com; iwrot@wp.pl;
   veronica.ratajczak@gmail.com; olimpiasipak-szmigiel@wp.pl;
   mpiasecka@ipartner.com.pl; barbara.dolegowska@pum.edu.pl;
   maria@laszczynska.pl
RI Sipak-Szmigiel, Olimpia/A-5562-2016; Slojewski, Marcin/P-6992-2014;
   Stachowska, Ewa/G-9521-2017; Dolegowska, Barbara/O-4851-2014; Ratajczak,
   Weronika/K-5821-2018; Rotter, Iwona/O-6539-2014; Ryl,
   Aleksandra/L-6760-2015; Laszczynska, Maria/O-7371-2014; Piasecka,
   Malgorzata/A-9894-2015
OI Stachowska, Ewa/0000-0002-4009-1977; Dolegowska,
   Barbara/0000-0003-3138-1013; Ratajczak, Weronika/0000-0002-8397-9757;
   Rotter, Iwona/0000-0002-4337-6476; Ryl, Aleksandra/0000-0002-5954-4489;
   Grzesiak, Katarzyna/0000-0003-2246-5549; Laszczynska,
   Maria/0000-0002-1580-1885; Sipak-Szmigiel, Olimpia/0000-0002-3410-1809;
   Slojewski, Marcin/0000-0003-3679-7325; Piasecka,
   Malgorzata/0000-0002-5914-2121
FU Pomeranian Medical University [WNoZ-322-02/S/17/2018]
FX The research was financed by Pomeranian Medical University grant number
   WNoZ-322-02/S/17/2018.
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Bednar MM, 2000, NEUROSURGERY, V47, P1410, DOI 10.1097/00006123-200012000-00029
   Bojic LA, 2016, ANAL BIOANAL CHEM, V408, P97, DOI 10.1007/s00216-015-9105-4
   Calder PC, 2010, NUTRIENTS, V2, P355, DOI 10.3390/nu2030355
   Careaga Quiroga V.P., 2015, RES CANC TUMOR, V4, P1
   De Nunzio C, 2012, EUR UROL, V61, P560, DOI 10.1016/j.eururo.2011.11.013
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   Fowke JH, 2007, PROSTATE CANCER P D, V10, P137, DOI 10.1038/sj.pcan.4500924
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Futosi K, 2013, INT IMMUNOPHARMACOL, V17, P638, DOI 10.1016/j.intimp.2013.06.034
   Gacci M, 2015, BJU INT, V115, P24, DOI 10.1111/bju.12728
   Ghosh J, 1998, P NATL ACAD SCI USA, V95, P13182, DOI 10.1073/pnas.95.22.13182
   Giskeodegård GF, 2015, BRIT J CANCER, V113, P1712, DOI 10.1038/bjc.2015.411
   Hsi LC, 2002, J BIOL CHEM, V277, P40549, DOI 10.1074/jbc.M203522200
   Huang X, 2014, J INTERN MED, V275, P71, DOI 10.1111/joim.12130
   Hughes-Fulford M, 2006, CANCER RES, V66, P1427, DOI 10.1158/0008-5472.CAN-05-0914
   Itoh T, 2008, NAT STRUCT MOL BIOL, V15, P924, DOI 10.1038/nsmb.1474
   Jack GS, 2000, HUM PATHOL, V31, P1146, DOI 10.1053/hupa.2000.16670
   Kim OY, 2013, NUTR METAB CARDIOVAS, V23, P366, DOI 10.1016/j.numecd.2011.06.006
   Larsson SC, 2004, AM J CLIN NUTR, V79, P935
   Lee HK, 2013, WORLD J MENS HEALTH, V31, P136, DOI 10.5534/wjmh.2013.31.2.136
   Lin L, 2018, INT ARCH ALLERGY IMM, V177, P107, DOI 10.1159/000489819
   MACICA C, 1993, AM J PHYSIOL, V265, pG735, DOI 10.1152/ajpgi.1993.265.4.G735
   Maciejewska D, 2015, PROSTAG OTH LIPID M, V121, P184, DOI 10.1016/j.prostaglandins.2015.09.003
   Maciejewska D, 2015, WORLD J GASTROENTERO, V21, P301, DOI 10.3748/wjg.v21.i1.301
   Mamalakis G, 2002, PROSTAG LEUKOTR ESS, V66, P467, DOI 10.1054/plef.2002.0384
   Mammi C, 2012, INT J ENDOCRINOL, V2012, DOI 10.1155/2012/789653
   Martin FPJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0073445
   Morgantini C, 2014, NUTR METAB CARDIOVAS, V24, P594, DOI 10.1016/j.numecd.2013.12.011
   Mosli HA, 2013, SPRINGERPLUS, V2, DOI 10.1186/2193-1801-2-537
   Nowak JZ, 2010, POSTEP HIG MED DOSW, V64, P115
   Ormseth MJ, 2013, LUPUS, V22, P26, DOI 10.1177/0961203312462756
   Parsons JK, 2013, J UROLOGY, V189, pS102, DOI 10.1016/j.juro.2012.11.029
   Pidgeon GP, 2002, CANCER RES, V62, P2721
   Powell WS, 2015, BBA-MOL CELL BIOL L, V1851, P340, DOI 10.1016/j.bbalip.2014.10.008
   Ross DJ, 2015, PULM CIRC, V5, P640, DOI 10.1086/683695
   Ryl A, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/s13098-015-0089-1
   Shappell SB, 2001, NEOPLASIA, V3, P287, DOI 10.1038/sj.neo.7900166
   Tunaru S, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-017-02539-4
   Vangaveti V, 2010, THER ADV ENDOCRINOL, V1, P51, DOI 10.1177/2042018810375656
   Vangaveti VN, 2016, EUR J PHARMACOL, V785, P70, DOI 10.1016/j.ejphar.2015.03.096
   Wang D, 2009, AM J PHYSIOL-REG I, V296, pR195, DOI 10.1152/ajpregu.90506.2008
   Weaver JR, 2012, MOL CELL ENDOCRINOL, V358, P88, DOI 10.1016/j.mce.2012.03.004
   Wesolowski P, 2011, NEPHROL DIAL POL, V15, P243
   Wittwer J, 2007, PROSTAG LEUKOTR ESS, V77, P67, DOI 10.1016/j.plefa.2007.08.001
   Yin Z, 2015, ASIAN J ANDROL, V17, P826, DOI 10.4103/1008-682X.148081
   Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431
NR 47
TC 3
Z9 3
U1 1
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-7827
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD MAR 2
PY 2019
VL 16
IS 6
AR 1006
DI 10.3390/ijerph16061006
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA HU3GB
UT WOS:000465159500106
PM 30897712
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Teng, CF
   Hsieh, WC
   Yang, CW
   Su, HM
   Tsai, TF
   Sung, WC
   Huang, WY
   Su, IJ
AF Teng, Chiao-Fang
   Hsieh, Wen-Chuan
   Yang, Ching-Wen
   Su, Hui-Min
   Tsai, Ting-Fen
   Sung, Wang-Chou
   Huang, Wenya
   Su, Ih-Jen
TI A Biphasic Response Pattern of Lipid Metabolomics in the Stage
   Progression of Hepatitis B Virus X Tumorigenesis
SO MOLECULAR CARCINOGENESIS
LA English
DT Article
DE metabolic syndrome; hepatocellular carcinoma; triglycerides;
   cholesterol; fatty acids
ID GROUND-GLASS HEPATOCYTES; PROTEIN TRANSGENIC MICE; PRIMARY LIVER-CANCER;
   HEPATOCELLULAR-CARCINOMA; FATTY LIVER; MOUSE MODEL; PATHOGENESIS;
   METABOLISM; EXPRESSION; MTOR
AB Metabolic syndrome has closely linked to the development of human hepatocellular carcinoma (HCC). By using the hepatitis B virus (HBV) X (HBx) transgenic mouse model, we studied the dynamic evolution of serum and liver profiles of lipids and global cDNA expression at different stages of HBx tumorigenesis. We observed that the lipid (triglycerides, cholesterol, and fatty acids) profiles revealed a biphasic response pattern during the progression of HBx tumorigenesis: a small peak at early phase and a large peak or terminal switch at the tumor phase. By analyzing cDNA microarray data, the early peak correlated to the oxidative stress and pro-inflammatory response, which then resolved at the middle phase and were followed by the terminal metabolic switch in the tumor tissues. Five lipid metabolism-related genes, the arachidonate 5-lipoxygenase, lipoprotein lipase, fatty acid binding protein 4, 1-acylglycerol-3-phosphate O-acyltransferase 9, and apolipoprotein A-IV were identified to be significantly activated in HBx transgenic HCCs and further validated in human HBV-related HCCs. Inhibition of these lipid genes could reverse the effect of HBx on lipid biosynthesis and suppress HBx-induced cell proliferation in vitro. Our results support the concept that metabolic syndrome plays an important role in HBV tumorigenesis. The dysregulation of lipid metabolic genes may predict the disease progression to HCC in chronic hepatitis B patients. (C) 2015 Wiley Periodicals, Inc.
C1 [Teng, Chiao-Fang; Hsieh, Wen-Chuan; Sung, Wang-Chou; Su, Ih-Jen] Natl Hlth Res Inst, Natl Inst Infect Dis & Vaccinol, 367 Sheng Li Rd, Tainan 704, Taiwan.
   [Yang, Ching-Wen; Su, Ih-Jen] Natl Cheng Kung Univ, Coll Med, Inst Basic Med Res, Tainan 70101, Taiwan.
   [Su, Hui-Min] Natl Taiwan Univ, Coll Med, Dept Physiol, Taipei 10764, Taiwan.
   [Tsai, Ting-Fen] Natl Yang Ming Univ, Dept Life Sci, Taipei 112, Taiwan.
   [Tsai, Ting-Fen] Natl Yang Ming Univ, Inst Genome Sci, Taipei 112, Taiwan.
   [Tsai, Ting-Fen] Natl Hlth Res Inst, Inst Mol & Genom Med, Zhunan, Taiwan.
   [Huang, Wenya] Natl Cheng Kung Univ, Coll Med, Dept Med Lab Sci & Biotechnol, Tainan 70101, Taiwan.
C3 National Health Research Institutes - Taiwan; National Cheng Kung
   University; National Taiwan University; National Yang Ming Chiao Tung
   University; National Yang Ming Chiao Tung University; National Health
   Research Institutes - Taiwan; National Cheng Kung University
RP Su, IJ (corresponding author), Natl Hlth Res Inst, 367 Sheng Li Rd, Tainan 704, Taiwan.
RI Su, Ih-Jen/B-2655-2010; Travassos, Leonardo/G-1925-2012; Teng,
   Chiao-Fang/L-6679-2013
OI Teng, Chiao-Fang/0000-0002-5218-0571; SU, HUI-MIN/0000-0002-9970-4459
CR Agarwal AK, 2007, J ENDOCRINOL, V193, P445, DOI 10.1677/JOe-07-0027
   [Anonymous], 1974, CULLING CFAHANDBOOK
   BEASLEY RP, 1981, LANCET, V2, P1129
   Bishayee A, 2010, CANCER TREAT REV, V36, P43, DOI 10.1016/j.ctrv.2009.10.002
   Bissell DM, 2001, HEPATOLOGY, V33, P1009, DOI 10.1053/jhep.2001.23505
   BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911
   CHEN CH, 1985, BIOCHIM BIOPHYS ACTA, V836, P279, DOI 10.1016/0005-2760(85)90131-6
   CHISARI FV, 1989, CELL, V59, P1145, DOI 10.1016/0092-8674(89)90770-8
   Choi J, 2006, AM J PHYSIOL-GASTR L, V290, pG847, DOI 10.1152/ajpgi.00522.2005
   Chung WL, 2008, J NUTR, V138, P1165, DOI 10.1093/jn/138.6.1165
   Cornu M, 2013, CURR OPIN GENET DEV, V23, P53, DOI 10.1016/j.gde.2012.12.005
   DeBerardinis RJ, 2008, CELL METAB, V7, P11, DOI 10.1016/j.cmet.2007.10.002
   Fehér J, 2012, CURR PHARM BIOTECHNO, V13, P210, DOI 10.2174/138920112798868818
   Furuhashi M, 2008, NAT REV DRUG DISCOV, V7, P489, DOI 10.1038/nrd2589
   Kew MC, 2011, J GASTROEN HEPATOL, V26, P144, DOI 10.1111/j.1440-1746.2010.06546.x
   Kutami R, 2000, J HEPATOL, V33, P282, DOI 10.1016/S0168-8278(00)80369-4
   Laplante M, 2009, CURR BIOL, V19, pR1046, DOI 10.1016/j.cub.2009.09.058
   Lin HC, 2012, CANCER PREV RES, V5, P952, DOI 10.1158/1940-6207.CAPR-12-0001
   Mead JR, 2002, J MOL MED, V80, P753, DOI 10.1007/s00109-002-0384-9
   Miller DM, 2012, CLIN CANCER RES, V18, P5546, DOI 10.1158/1078-0432.CCR-12-0977
   Nakamura MT, 2004, ANNU REV NUTR, V24, P345, DOI 10.1146/annurev.nutr.24.121803.063211
   Patterson AD, 2011, CANCER RES, V71, P6590, DOI 10.1158/0008-5472.CAN-11-0885
   Rådmark O, 2007, TRENDS BIOCHEM SCI, V32, P332, DOI 10.1016/j.tibs.2007.06.002
   Ricchi M, 2009, J GASTROEN HEPATOL, V24, P830, DOI 10.1111/j.1440-1746.2008.05733.x
   Siegel AB, 2009, CANCER-AM CANCER SOC, V115, P5651, DOI 10.1002/cncr.24687
   Sitia G, 2012, P NATL ACAD SCI USA, V109, pE2165, DOI 10.1073/pnas.1209182109
   Starley BQ, 2010, HEPATOLOGY, V51, P1820, DOI 10.1002/hep.23594
   Su Ih-Jen, 2013, Hepatobiliary Surg Nutr, V2, P37, DOI 10.3978/j.issn.2304-3881.2012.10.08
   Teng CF, 2011, HEPATOLOGY, V54, P1199, DOI 10.1002/hep.24529
   Wang HC, 2005, HEPATOLOGY, V41, P761, DOI 10.1002/hep.20615
   Welzel TM, 2011, HEPATOLOGY, V54, P463, DOI 10.1002/hep.24397
   Wu BK, 2006, BIOCHEM BIOPH RES CO, V340, P916, DOI 10.1016/j.bbrc.2005.12.089
   Wu HC, 2014, HUM PATHOL, V45, P1294, DOI 10.1016/j.humpath.2013.10.039
   Wu YF, 2008, CANCER RES, V68, P2033, DOI 10.1158/0008-5472.CAN-07-2450
   Yang JC, 2009, HEPATOLOGY, V49, P1962, DOI 10.1002/hep.22889
   Yang PL, 2010, P NATL ACAD SCI USA, V107, P798, DOI 10.1073/pnas.0913498107
NR 36
TC 27
Z9 28
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0899-1987
EI 1098-2744
J9 MOL CARCINOGEN
JI Mol. Carcinog.
PD JAN
PY 2016
VL 55
IS 1
BP 105
EP 114
DI 10.1002/mc.22266
PG 10
WC Biochemistry & Molecular Biology; Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Oncology
GA DB9BE
UT WOS:000368810100010
PM 25594851
DA 2025-06-11
ER

PT J
AU Woods-Giscombe, CL
   Gaylord, S
   Bradford, A
   Vines, S
   Eason, K
   Smith, R
   Addo-Mensah, D
   Lackey, C
   Dsouza, V
   Sheffield-Abdullah, K
   Day, T
   Green-Scott, K
   Chilcoat, A
   Peace-Coard, A
   Chalmers, L
   Evenson, KR
   Samuel-Hodge, C
   Lewis, TT
   Crandell, J
   Corbie, G
   Faurot, K
AF Woods-Giscombe, Cheryl L.
   Gaylord, Susan
   Bradford, Andrew
   Vines, Sierra
   Eason, Kelly
   Smith, Raven
   Addo-Mensah, Dorothy
   Lackey, Charity
   Dsouza, Vinisha
   Sheffield-Abdullah, Karen
   Day, Tomeka
   Green-Scott, Kerri
   Chilcoat, Aisha
   Peace-Coard, Angela
   Chalmers, LaTonia
   Evenson, Kelly R.
   Samuel-Hodge, Carmen
   Lewis, Tene T.
   Crandell, Jamie
   Corbie, Giselle
   Faurot, Keturah
TI Protocol of the HARMONY study: A culturally relevant,
   randomized-controlled, stress management intervention to reduce
   cardiometabolic risk in African American women
SO CONTEMPORARY CLINICAL TRIALS
LA English
DT Article
DE African American; Women; Cardiometabolic disease; Stress management;
   Superwoman schema
ID WEIGHT-LOSS; PHYSICAL-ACTIVITY; HEALTH BEHAVIORS; MINDFULNESS;
   RECOMMENDATIONS; WHITE; QUESTIONNAIRE; METAANALYSIS; VALIDATION;
   STRENGTH
AB Background: African American Women (AAW) are at high risk for stress-related cardiometabolic (CM) conditions including obesity, heart disease, and diabetes. Prior interventions lack attention to culturally-nuanced stress phenomena (Superwoman Schema [SWS], contextualized stress, and network stress), which are positively and significantly associated with unhealthy eating and sedentary behavior. Purpose: The HARMONY Study is designed to test a culturally tailored mindfulness-based stress management intervention to address SWS, contextualized stress, and network stress as potential barriers to adherence to healthy exercise and eating goals. The study will help AAW build on their strengths to promote cardiometabolic health by enhancing positive reappraisal, self-regulation, and self-efficacy as protective factors against chronic stress-inducing biobehavioral morbidity and mortality risk. Methods: This two-arm, randomized-controlled trial will test the effects of two group-based, online interventions. HARMONY 1 includes culturally-tailored exercise and nutrition education. HARMONY 2 includes mindfulnessbased stress reduction, exercise, and nutrition education. We aim to recruit 200 AAW >= 18 years old with CM risk. Results: Primary outcomes (actigraphy and carotenoid levels) and secondary outcomes (body composition, inflammatory markers, glucose metabolism, and stress) are being collected at baseline and 4-, 8-, and 12-months post-intervention. Intent-to-treat, data analytic approaches will be used to test group differences for the primary outcomes. Discussion: This study is the first to address culturally-nuanced stress phenomena in AAW (SWS, network stress, and contextualized stress) using culturally-tailored stress management, exercise, and nutrition educational approaches to reduce biobehavioral CM risk among AAW. Quantitative and qualitative results will inform the development of scalable and sustainable CM risk-reduction programming for AAW.
C1 [Woods-Giscombe, Cheryl L.; Bradford, Andrew; Vines, Sierra; Smith, Raven; Addo-Mensah, Dorothy; Lackey, Charity; Dsouza, Vinisha; Sheffield-Abdullah, Karen; Day, Tomeka; Green-Scott, Kerri; Peace-Coard, Angela; Chalmers, LaTonia; Crandell, Jamie] Univ N Carolina, Sch Nursing, Chapel Hill, NC 27599 USA.
   [Gaylord, Susan] Univ N Carolina, Sch Med, Program Integrated Med, Chapel Hill, NC USA.
   [Eason, Kelly; Chilcoat, Aisha; Faurot, Keturah] Univ N Carolina, Sch Med, Phys Med Rehab, Chapel Hill, NC USA.
   [Evenson, Kelly R.; Samuel-Hodge, Carmen] Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA.
   [Lewis, Tene T.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA USA.
   [Corbie, Giselle] Univ N Carolina, Sch Med, Dept Social Med, Chapel Hill, NC USA.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina School of Medicine; University of North
   Carolina; University of North Carolina Chapel Hill; University of North
   Carolina School of Medicine; University of North Carolina; University of
   North Carolina Chapel Hill; University of North Carolina; University of
   North Carolina Chapel Hill; Emory University; Rollins School Public
   Health; University of North Carolina School of Medicine; University of
   North Carolina; University of North Carolina Chapel Hill
RP Woods-Giscombe, CL (corresponding author), Univ N Carolina, Sch Nursing, Chapel Hill, NC 27599 USA.
EM cheryl.giscombe@unc.edu
RI Evenson, Kelly/ABU-8365-2022; Lewis, Tene/JBS-7332-2023; GISCOMBE,
   CHERYL/AAG-5815-2020; Crandell, Jamie/KCX-8061-2024
OI Addo-Mensah, Dorothy/0000-0002-2867-618X; Wright-Smith,
   Raven/0000-0002-8750-5073; Dsouza, Vinisha Flavia/0000-0002-4046-9802
FU National Institutes of Health (NIH) : National Institute on Minority
   Health and Health Disparities [1R01MDO15388-04]; National Institute of
   Complementary and Integrative Health [2T32AT003378-16]; National Center
   for Advancing Translational Sciences [UM1TR004406]
FX This work was supported by the National Institutes of Health (NIH) :
   National Institute on Minority Health and Health Disparities (Grant #:
   1R01MDO15388-04) , the National Institute of Complementary and
   Integrative Health (Grant #: 2T32AT003378-16) , and the National Center
   for Advancing Translational Sciences (Grant #: UM1TR004406) .
CR Abbott RA, 2014, J PSYCHOSOM RES, V76, P341, DOI 10.1016/j.jpsychores.2014.02.012
   Allen AM, 2019, ANN NY ACAD SCI, V1457, P104, DOI 10.1111/nyas.14188
   [Anonymous], 2016, NINR Demographics
   [Anonymous], 2017, STRESS HLTH DISPARIT
   [Anonymous], 2016, The VEGGIE METER - skin carotenoids as indicator of fruit and vegetable intake and biomarker associated with better health
   [Anonymous], 2015, Fitabase-Research Device Data and Analytics
   [Anonymous], About us
   Baer RA, 2008, ASSESSMENT, V15, P329, DOI 10.1177/1073191107313003
   Bellg AJ, 2004, HEALTH PSYCHOL, V23, P443, DOI 10.1037/0278-6133.23.5.443
   BORKOVEC TD, 1972, J BEHAV THER EXP PSY, V3, P257, DOI 10.1016/0005-7916(72)90045-6
   Burnett-Zeigler IE, 2016, COMPLEMENT THER CLIN, V25, P59, DOI 10.1016/j.ctcp.2016.08.007
   Callaway CW., 1988, ANTHROPOMETRIC STAND, P39
   Carson TL, 2017, TRANSL BEHAV MED, V7, DOI 10.1007/s13142-016-0452-2
   Chatzisarantis NLD, 2007, PERS SOC PSYCHOL B, V33, P663, DOI 10.1177/0146167206297401
   Chrousos GP, 1998, J CLIN ENDOCR METAB, V83, P1842, DOI 10.1210/jc.83.6.1842
   Chung SY, 2016, SUPPORT CARE CANCER, V24, P1875, DOI 10.1007/s00520-015-2984-2
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Connor KM, 2003, DEPRESS ANXIETY, V18, P76, DOI 10.1002/da.10113
   Cook-Cottone CP., 2014, PsycTests Dataset, DOI [DOI 10.1037/T66058-000, 10.1037/t66058-000]
   Cox TL, 2013, HEALTH EDUC BEHAV, V40, P78, DOI 10.1177/1090198112439411
   DiClemente CC, 2004, AM J ADDICTION, V13, P103, DOI 10.1080/10550490490435777
   Dutton MA, 2013, COGN BEHAV PRACT, V20, P23, DOI 10.1016/j.cbpra.2011.08.003
   Embree GGR, 2017, BMJ OPEN DIAB RES CA, V5, DOI 10.1136/bmjdrc-2016-000339
   Evenson Kelly R, 2015, BMC Res Notes, V8, P7, DOI 10.1186/s13104-014-0970-2
   Evenson KR, 2015, INT J BEHAV NUTR PHY, V12, DOI 10.1186/s12966-015-0183-7
   Fisher G, 2012, OBESITY, V20, P715, DOI 10.1038/oby.2011.85
   Garland EL, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0187727
   Garland EL, 2017, COGNITIVE THER RES, V41, P381, DOI 10.1007/s10608-016-9768-y
   Garnefski N, 2006, PERS INDIV DIFFER, V41, P1045, DOI 10.1016/j.paid.2006.04.010
   Gill LE, 2015, CURR OBES REP, V4, P379, DOI 10.1007/s13679-015-0161-z
   Gruber-Baldini AL, 2017, QUAL LIFE RES, V26, P1915, DOI 10.1007/s11136-017-1527-3
   Harris PA, 2009, J BIOMED INFORM, V42, P377, DOI 10.1016/j.jbi.2008.08.010
   Hollis JF, 2008, AM J PREV MED, V35, P118, DOI 10.1016/j.amepre.2008.04.013
   Jackson FM, 2005, ETHNIC DIS, V15, P594
   Jilcott SB, 2007, J AM DIET ASSOC, V107, P246, DOI 10.1016/j.jada.2006.11.006
   Joseph RP, 2017, J RACIAL ETHN HEALTH, V4, P397, DOI 10.1007/s40615-016-0240-1
   Kabat-Zinn J., 2005, HYPERION
   Kang Augustine W, 2018, Prev Med Rep, V12, P25, DOI 10.1016/j.pmedr.2018.08.002
   Kumanyika SK, 2002, OBES RES, V10, P96, DOI 10.1038/oby.2002.16
   Lewis TT, 2023, HEALTH PSYCHOL, V42, P485, DOI 10.1037/hea0001309
   Lobel M, 2000, HEALTH PSYCHOL, V19, P544, DOI 10.1037/0278-6133.19.6.544
   MacIntosh BA, 2013, BRIT J NUTR, V110, P559, DOI 10.1017/S0007114512005181
   Martin ZT, 2023, HYPERTENSION, V80, P2122, DOI 10.1161/HYPERTENSIONAHA.123.21230
   Mason AE, 2016, APPETITE, V100, P86, DOI 10.1016/j.appet.2016.02.009
   MCEWEN BS, 1993, ARCH INTERN MED, V153, P2093, DOI 10.1001/archinte.153.18.2093
   Mezuk B, 2013, SOC MENT HEALTH, V3, P79, DOI 10.1177/2156869313480892
   Mozaffarian D, 2016, CIRCULATION, V133, pE38, DOI 10.1161/CIR.0000000000000350
   Najjar M F, 1987, Vital Health Stat 11, P1
   National Academy of Sports Medicine, 2016, Physical Activity Readiness Questionnaire for Everyone
   National Center for Health Statistics (US) Health United States, 2016, 2015: With Special Feature on Racial and Ethnic Health Disparities
   National Insitutes of Health, 2000, The Practical Guide: Identification, Evaluation, and Treatment of Overweight and Obesity in Adults 4084
   Ng DM, 2003, HEALTH PSYCHOL, V22, P638, DOI 10.1037/0278-6133.22.6.638
   Nigg CR, 2008, APPL PSYCHOL-INT REV, V57, P544, DOI 10.1111/j.1464-0597.2008.00343.x
   Payne Nicola, 2002, J Occup Health Psychol, V7, P342, DOI 10.1037/1076-8998.7.4.342
   Pickering TG, 2005, HYPERTENSION, V45, P142, DOI 10.1161/01.HYP.0000150859.47929.8e
   PIPER WE, 1983, HUM RELAT, V36, P93, DOI 10.1177/001872678303600201
   Resnicow Ken, 1999, Ethnicity and Disease, V9, P10
   Rogers JM, 2017, OBES REV, V18, P51, DOI 10.1111/obr.12461
   Ruffault A, 2016, MINDFULNESS, V7, P445, DOI 10.1007/s12671-015-0467-7
   Sharma M, 2014, J EVID-BASED INTEGR, V19, P271, DOI 10.1177/2156587214543143
   Szanton SL, 2005, BIOL RES NURS, V7, P7, DOI 10.1177/1099800405278216
   Warburton DER, 2011, APPL PHYSIOL NUTR ME, V36, pS1, DOI [10.1139/h11-060, 10.1139/H11-060]
   Watson-Singleton NN, 2019, COMPLEMENT THER CLIN, V34, P132, DOI 10.1016/j.ctcp.2018.11.013
   West DS, 2008, OBESITY, V16, P1413, DOI 10.1038/oby.2008.224
   Woods-Giscombe CL, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/3962623
   Woods-Giscombe CL, 2019, ISSUES MENT HEALTH N, V40, P672, DOI 10.1080/01612840.2019.1584654
   Woods-Giscombé CL, 2015, ISSUES MENT HEALTH N, V36, P710, DOI 10.3109/01612840.2015.1011759
   Woods-Giscombé CL, 2014, J HOLIST NURS, V32, P147, DOI 10.1177/0898010113519010
   Woods-Giscombé CL, 2010, J EVID-BASED INTEGR, V15, P115, DOI 10.1177/1533210110386776
   Woods-Giscombé CL, 2010, QUAL HEALTH RES, V20, P668, DOI 10.1177/1049732310361892
   Woods-Giscombé CL, 2008, CULT DIVERS ETHN MIN, V14, P173, DOI 10.1037/1099-9809.14.3.173
NR 71
TC 0
Z9 0
U1 3
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1551-7144
EI 1559-2030
J9 CONTEMP CLIN TRIALS
JI Contemp. Clin. Trials
PD NOV
PY 2024
VL 146
AR 107604
DI 10.1016/j.cct.2024.107604
EA SEP 2024
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA H1I5C
UT WOS:001321046200001
PM 38866096
DA 2025-06-11
ER

PT J
AU Wang, DQ
   Wang, XH
   Han, J
   You, CP
   Liu, ZM
   Wu, ZJ
AF Wang, Danqi
   Wang, Xiaohua
   Han, Jin
   You, Chunping
   Liu, Zhenmin
   Wu, Zhengjun
TI Effect of Lacticaseibacillus casei LC2W Supplementation on
   Glucose Metabolism and Gut Microbiota in Subjects at High Risk of
   Metabolic Syndrome: A Randomized, Double-blinded, Placebo-controlled
   Clinical Trial
SO PROBIOTICS AND ANTIMICROBIAL PROTEINS
LA English
DT Article; Early Access
DE Lacticaseibacillus casei LC2W; Metabolic syndrome; Glucose;
   Inflammation; Gut microbiome
ID MUCOSA; WOMEN; DIET
AB Metabolic syndrome (MetS) is a global epidemic complex and will cause serious metabolic comorbidities without treatment. A prevention strategy for MetS development has been proposed to modulate gut microbiota by probiotic administration to improve intestinal dysbiosis and benefit the host. Lacticaseibacillus casei LC2W has exhibited positive effects in preventing colitis and anti-hypertension in vivo. However, the effect of L. casei LC2W on subjects at high risk of MetS is unknown. Here, a randomized, double-blinded, placebo-controlled study was conducted on 60 subjects with high risk of MetS, and the hypoglycemic and hypolipidemic activity and possible pathways of L. casei LC2W were inferred from the correlation analysis with gut microbiome composition, function, and clinical phenotypic indicators. The results showed that oral administration of L. casei LC2W could exert significant benefits on weight control, glucose and lipid metabolism, inflammatory and oxidative stress parameters, and SCFA production, as well as modulate the composition of gut microbiota. The relative abundance of Lacticaseibacillus, Bifidobacterium, Dorea, and Blautia was enriched, and their interaction with other gut microbes was strengthened by oral administration of L. casei LC2W, which was beneficial in ameliorating gut inflammation, promoting glucose and lipids degradation pathways, thus alleviated MetS. The present study confirmed the prevention effects of L. casei LC2W towards MetS from aspects of clinical outcomes and microflora modulation, providing an alternative strategy for people at high risk of MetS.
C1 [Wang, Danqi; Wang, Xiaohua; Han, Jin; You, Chunping; Liu, Zhenmin; Wu, Zhengjun] Bright Dairy & Food Co Ltd, Shanghai Engn Res Ctr Dairy Biotechnol, Dairy Res Inst, State Key Lab Dairy Biotechnol, Shanghai 200436, Peoples R China.
C3 Bright Dairy & Food Co Ltd
RP Wu, ZJ (corresponding author), Bright Dairy & Food Co Ltd, Shanghai Engn Res Ctr Dairy Biotechnol, Dairy Res Inst, State Key Lab Dairy Biotechnol, Shanghai 200436, Peoples R China.
EM wuzhengjun@brightdairy.com
RI liu, zhenmin/LUY-2605-2024
FU Natural Science Foundation of Shanghai [23ZR1414400]; National Key
   Research and Development Program of China [2022YFD2100704]; Shanghai
   State-owned Assets Supervision and Administration Commission Enterprise
   Innovation Development and Capacity Enhancement Program [2022013]
FX The Natural Science Foundation of Shanghai, 23ZR1414400, 23ZR1414400,
   23ZR1414400, 23ZR1414400, National Key Research and Development Program
   of China, 2022YFD2100704, 2022YFD2100704, The Shanghai State-owned
   Assets Supervision and Administration Commission Enterprise Innovation
   Development and Capacity Enhancement Program, No. 2022013.
CR Aday AW, 2019, FRONT CARDIOVASC MED, V6, DOI 10.3389/fcvm.2019.00016
   Axling U, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-105
   Barreto FM, 2014, NUTRITION, V30, P939, DOI 10.1016/j.nut.2013.12.004
   Benítez-Páez A, 2020, MSYSTEMS, V5, DOI 10.1128/mSystems.00857-19
   Chen C, 2011, J BACTERIOL, V193, P3419, DOI 10.1128/JB.05017-11
   Chen Y, 2014, AMINO ACIDS, V46, P1131, DOI 10.1007/s00726-014-1675-5
   Dabke K, 2019, J CLIN INVEST, V129, P4050, DOI 10.1172/JCI129194
   Douglas GM, 2020, NAT BIOTECHNOL, V38, P685, DOI 10.1038/s41587-020-0548-6
   [范文娅 Fan Wenya], 2012, [食品与发酵工业, Food and Fermentation Industries], V38, P29
   Feehley T, 2019, NAT MED, V25, P448, DOI 10.1038/s41591-018-0324-z
   Fung TC, 2019, NAT MICROBIOL, V4, P2064, DOI 10.1038/s41564-019-0540-4
   Gaundal L, 2022, FOOD NUTR RES, V66, DOI 10.29219/fnr.v66.8580
   Ge HS, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-77184-x
   Gustafsson RJ, 2012, WORLD J GASTROENTERO, V18, P1628, DOI 10.3748/wjg.v18.i14.1628
   Horigome A, 2022, FRONT MICROBIOL, V13, DOI 10.3389/fmicb.2022.913624
   Hosomi K, 2022, NAT COMMUN, V13, DOI 10.1038/s41467-022-32015-7
   Ilyés T, 2022, BIOLOGY-BASEL, V11, DOI 10.3390/biology11111556
   Jin CJ, 2007, J NUTR, V137, P339, DOI 10.1093/jn/137.2.339
   Joly A, 2021, TRENDS MICROBIOL, V29, P686, DOI 10.1016/j.tim.2020.11.007
   Kanai M, 2017, APPL MICROBIOL BIOT, V101, P1351, DOI 10.1007/s00253-017-8098-7
   Kanazawa A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020558
   Kim YT, 2022, FRONT MICROBIOL, V13, DOI 10.3389/fmicb.2022.886934
   Li XF, 2016, RSC ADV, V6, P63536, DOI 10.1039/c6ra10858j
   Li Y, 2022, CELL MOL IMMUNOL, V19, P791, DOI 10.1038/s41423-022-00871-4
   Liu M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0066233
   Liu XM, 2021, GUT MICROBES, V13, DOI 10.1080/19490976.2021.1875796
   Mandaliya DK, 2019, PANCREATOLOGY, V19, P280, DOI 10.1016/j.pan.2019.01.021
   Mao KM, 2022, FRONT NUTR, V8, DOI 10.3389/fnut.2021.811619
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   Mohammadi-Sartang M, 2018, NUTR METAB CARDIOVAS, V28, P565, DOI 10.1016/j.numecd.2018.03.001
   Moon MK, 2010, EXP MOL MED, V42, P345, DOI 10.3858/emm.2010.42.5.036
   Nomura K, 2021, J CLIN MED, V10, DOI 10.3390/jcm10081749
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Otte E, 2017, ANAEROBE, V43, P91, DOI 10.1016/j.anaerobe.2016.12.010
   Rajilic-Stojanovic M, 2015, AM J GASTROENTEROL, V110, P278, DOI 10.1038/ajg.2014.427
   Samson SL, 2014, ENDOCRIN METAB CLIN, V43, P1, DOI 10.1016/j.ecl.2013.09.009
   Segata N, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-6-r60
   Song X, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01882
   Sookoian S, 2011, CURR HYPERTENS REP, V13, P149, DOI 10.1007/s11906-010-0164-9
   Tanase DM, 2020, NUTRIENTS, V12, DOI 10.3390/nu12123719
   Tenorio-Jiménez C, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081761
   Wang GQ, 2019, FOOD FUNCT, V10, P5843, DOI [10.1039/c9fo01390c, 10.1039/C9FO01390C]
   Weigert C, 2006, J BIOL CHEM, V281, P7060, DOI 10.1074/jbc.M509782200
   Weismann D, 2011, NATURE, V478, P76, DOI 10.1038/nature10449
   Wieërs G, 2020, FRONT CELL INFECT MI, V9, DOI 10.3389/fcimb.2019.00454
   Wilkins LJ, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-49452-y
   Xiao SM, 2014, FEMS MICROBIOL ECOL, V87, P357, DOI 10.1111/1574-6941.12228
   Younus H, 2018, INT J HEALTH SCI-IJH, V12, P88
   Zeng Z, 2021, FOOD FUNCT, V12, P6809, DOI [10.1039/d1fo00515d, 10.1039/D1FO00515D]
   Zeng Z, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201900457
   Zhang CH, 2010, ISME J, V4, P232, DOI 10.1038/ismej.2009.112
   Zhao L, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-19839-5
   Zhuang M, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201801187
NR 53
TC 0
Z9 0
U1 1
U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1867-1306
EI 1867-1314
J9 PROBIOTICS ANTIMICRO
JI Probiotics Antimicrob. Proteins
PD 2024 JUL 2
PY 2024
DI 10.1007/s12602-024-10312-5
EA JUL 2024
PG 15
WC Biotechnology & Applied Microbiology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Microbiology
GA XJ0I7
UT WOS:001261195400001
PM 38954305
OA hybrid
DA 2025-06-11
ER

PT J
AU D'Amico, R
   Siracusa, R
   Cordaro, M
   Fusco, R
   Arangia, A
   Interdonato, L
   Marino, Y
   Franco, GA
   Cuzzocrea, S
   Di Paola, R
   Impellizzeri, D
AF D'Amico, Ramona
   Siracusa, Rosalba
   Cordaro, Marika
   Fusco, Roberta
   Arangia, Alessia
   Interdonato, Livia
   Marino, Ylenia
   Franco, Gianluca Antonio
   Cuzzocrea, Salvatore
   Di Paola, Rosanna
   Impellizzeri, Daniela
TI Osteopontin as a Biomarker for Early Diagnosis of Renal Damage during
   Experimental Metabolic Syndrome
SO JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
LA English
DT Article
DE metabolic syndrome; fructose; osteopontin; kidney injury; biomarker
ID TUBULOINTERSTITIAL INJURY; INTERSTITIAL FIBROSIS; DIETARY FRUCTOSE;
   OXIDATIVE STRESS; KIDNEY ISCHEMIA; DISEASE; PALMITOYLETHANOLAMIDE;
   INFLAMMATION; NEUROINFLAMMATION; STRATIFICATION
AB Background: Excess consumption of fructose is a significant factor in the development of metabolic syndrome (MetS). It may also play a role in the progress of chronic kidney disease (CKD). Osteopontin (OPN) is a pleiotropic, multi-phosphorylated glycoprotein which plays important roles in diseases as well as in a wide range of biological activities. Based on these findings, the aim of this study was to evaluate OPN as a biomarker for the early detection of renal injury during an experimental model of fructose associated MetS in mice.Methods: Male CD1 mice aged 8-10 weeks were used. Fructose mice were given 30% fructose solution in drinking water, while control mice were given normal drinking water for 56 days. At sacrifice, kidneys, blood and urine of mice were collected. Bio-chemical, histological (hematoxylin and eosin and Masson's trichrome), immunohistochemical and molecular analyses (western blot, real-time quantitative polymerase chain reaction (RT-qPCR)) were performed.Results: Compared to controls, Fructose mice showed increased levels of glucose, total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), alanine aminotransferase (ALT), and aspartate aminotransferase (AST), as well as creatinine and blood urea nitrogen (BUN). In addition, significant histological kidney injury and fibrosis were observed in Fructose mice. These alterations were associated with increased levels of plasma and renal tissue OPN. Conclusions: Thus, new biomarkers such as OPN can be clinically useful to help predict kidney damage in MetS.
C1 [D'Amico, Ramona; Siracusa, Rosalba; Fusco, Roberta; Arangia, Alessia; Interdonato, Livia; Marino, Ylenia; Cuzzocrea, Salvatore; Impellizzeri, Daniela] Univ Messina, Dept ChemBiol Pharmaceut & Environm Sci, I-98166 Messina, Italy.
   [Cordaro, Marika] Univ Messina, Dept Biomed Dent & Morphol & Funct Imaging, I-98125 Messina, Italy.
   [Franco, Gianluca Antonio; Di Paola, Rosanna] Univ Messina, Dept Vet Sci, I-98168 Messina, Italy.
C3 University of Messina; University of Messina; University of Messina
RP Di Paola, R (corresponding author), Univ Messina, Dept Vet Sci, I-98168 Messina, Italy.
EM dipaolar@unime.it
RI FUSCO, Roberta/AAC-1745-2019; Impellizzeri, Daniela/K-6087-2016;
   Cuzzocrea, Salvatore/K-4734-2016; Siracusa, Rosalba/AAC-3110-2022;
   Cordaro, Marika/K-7329-2016; D'Amico, Ramona/AAC-9061-2019
CR Ahangarpour A, 2012, IRAN J MED SCI, V37, P181
   Ajiboye TO, 2017, J ETHNOPHARMACOL, V198, P184, DOI 10.1016/j.jep.2016.11.043
   Andres-Hernando A, 2023, BIOMOLECULES, V13, DOI 10.3390/biom13050780
   Aoyama M, 2012, BIOCHEM BIOPH RES CO, V419, P244, DOI 10.1016/j.bbrc.2012.02.001
   Bjornstad P, 2015, DIABETOLOGIA, V58, P1993, DOI 10.1007/s00125-015-3650-4
   Chang CL, 2018, AM J TRANSL RES, V10, P1053
   Cheng YR, 2022, PLOS GENET, V18, DOI 10.1371/journal.pgen.1010139
   Cho Y, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph192215003
   Coculescu BI, 2019, J ENZYM INHIB MED CH, V34, P783, DOI 10.1080/14756366.2019.1587418
   Cordaro M, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10061448
   Cordaro M, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9080660
   D'Amico R, 2022, NUTRIENTS, V14, DOI 10.3390/nu14071474
   Delbridge LMD, 2016, DIABETES, V65, P3521, DOI 10.2337/db16-0682
   Di Paola R, 2012, SHOCK, V38, P356, DOI 10.1097/SHK.0b013e318267bbb9
   Du YX, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.1014853
   Flisinski M, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23010203
   Gao N, 2020, J CEREBR BLOOD F MET, V40, P35, DOI 10.1177/0271678X19836412
   García-Arroyo FE, 2019, FREE RADICAL BIO MED, V141, P182, DOI 10.1016/j.freeradbiomed.2019.06.016
   Hatipoglu OF, 2021, BIOMED PHARMACOTHER, V139, DOI 10.1016/j.biopha.2021.111633
   Hayden MR, 2023, MEDICINA-LITHUANIA, V59, DOI 10.3390/medicina59030561
   Impellizzeri D, 2015, EUR J PHARMACOL, V762, P136, DOI 10.1016/j.ejphar.2015.05.010
   Irita J, 2011, AM J PHYSIOL-RENAL, V301, pF833, DOI 10.1152/ajprenal.00557.2010
   Kiss T, 2021, PATHOL ONCOL RES, V27, DOI 10.3389/pore.2021.581395
   Li Q, 2021, AGING-US, V13, P10326, DOI 10.18632/aging.202794
   Lin EYH, 2023, INT IMMUNOL, V35, P171, DOI 10.1093/intimm/dxac060
   Lin LR, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.904001
   Lozano I, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0074-1
   Mohamed IA, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8121558
   Nakagawa T, 2020, J AM SOC NEPHROL, V31, P898, DOI 10.1681/ASN.2019101015
   Nakayama T, 2010, AM J PHYSIOL-RENAL, V298, pF712, DOI 10.1152/ajprenal.00433.2009
   Nicholas SB, 2010, KIDNEY INT, V77, P588, DOI 10.1038/ki.2009.518
   Ophascharoensuk V, 1999, KIDNEY INT, V56, P571, DOI 10.1046/j.1523-1755.1999.00580.x
   Pagel CN, 2014, J CELL COMMUN SIGNAL, V8, P95, DOI 10.1007/s12079-013-0217-3
   Pereira TA, 2016, INT J PARASITOL, V46, P829, DOI 10.1016/j.ijpara.2016.08.004
   Shen JY, 2016, PHYTOMEDICINE, V23, P1504, DOI 10.1016/j.phymed.2016.08.009
   Si JY, 2020, MED SCI MONITOR, V26, DOI 10.12659/MSM.919159
   Sinha SK, 2023, BIOMEDICINES, V11, DOI 10.3390/biomedicines11051356
   Siracusa R, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22083991
   Siracusa R, 2015, CNS NEUROL DISORD-DR, V14, P1350, DOI 10.2174/1871527314666150821102823
   Softic S, 2016, DIGEST DIS SCI, V61, P1282, DOI 10.1007/s10620-016-4054-0
   Srikanthan K, 2016, INT J MED SCI, V13, P25, DOI 10.7150/ijms.13800
   Steinbrenner I, 2023, NEPHROL DIAL TRANSPL, V38, P1430, DOI 10.1093/ndt/gfac173
   Tan YY, 2022, FRONT ONCOL, V12, DOI 10.3389/fonc.2022.953283
   Tang Z, 2023, Cytokine & Growth Factor Reviews
   Toda C, 2016, CELL, V164, P872, DOI 10.1016/j.cell.2016.02.010
   Toyoda K, 2018, J TOXICOL SCI, V43, P45, DOI 10.2131/jts.43.45
   Trostel J, 2018, AM J PHYSIOL-RENAL, V315, pF759, DOI 10.1152/ajprenal.00458.2017
   Vianello E, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21155568
   Wang XL, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.705838
   Xu MX, 2016, BRAIN BEHAV IMMUN, V58, P69, DOI 10.1016/j.bbi.2016.01.001
   Yan XX, 2010, CARDIOVASC DIABETOL, V9, DOI 10.1186/1475-2840-9-70
   Yang M, 2018, BIOMED PHARMACOTHER, V105, P1283, DOI 10.1016/j.biopha.2018.06.108
   Yang M, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-174
   Zhang ZX, 2010, J IMMUNOL, V185, P967, DOI 10.4049/jimmunol.0903245
NR 54
TC 1
Z9 1
U1 1
U2 4
PU BIOLIFE SAS
PI SILVA MARINA (TE)
PA VIA S STEFANO 39 BIS, 64029 SILVA MARINA (TE), ITALY
SN 0393-974X
EI 1724-6083
J9 J BIOL REG HOMEOS AG
JI J. Biol. Regul. Homeost. Agents
PD DEC
PY 2023
VL 37
IS 12
BP 6501
EP 6510
DI 10.23812/j.biol.regul.homeost.agents.20233712.615
PG 10
WC Endocrinology & Metabolism; Immunology; Medicine, Research &
   Experimental; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Research & Experimental
   Medicine; Physiology
GA DX1X3
UT WOS:001135300400001
DA 2025-06-11
ER

PT J
AU Kountouras, J
   Kazakos, E
   Kyrailidi, F
   Polyzos, SA
   Zavos, C
   Arapoglou, S
   Boziki, M
   Mouratidou, MC
   Tzitiridou-Chatzopoulou, M
   Chatzopoulos, D
   Doulberis, M
   Papaefthymiou, A
   Vardaka, E
AF Kountouras, Jannis
   Kazakos, Evangelos
   Kyrailidi, Foteini
   Polyzos, Stergios A.
   Zavos, Christos
   Arapoglou, Stergios
   Boziki, Marina
   Mouratidou, Maria C.
   Tzitiridou-Chatzopoulou, Maria
   Chatzopoulos, Dimitrios
   Doulberis, Michael
   Papaefthymiou, Apostolis
   Vardaka, Elisabeth
TI Innate immunity and nonalcoholic fatty liver disease
SO ANNALS OF GASTROENTEROLOGY
LA English
DT Review
DE Innate immune response; nonalcoholic fatty liver disease;
   metabolic-associated fatty liver disease; liver fibrosis; metabolic
   syndrome
ID NATURAL-KILLER-CELLS; INTESTINAL MICROBIOTA; COMPLEMENT-SYSTEM; HEPATIC
   STEATOSIS; T-CELLS; STEATOHEPATITIS; ACTIVATION; FIBROSIS; INFLAMMATION;
   PROGRESSION
AB Nonalcoholic fatty liver disease (NAFLD), recently renamed as metabolic (dysfunction)-associated fatty liver disease (MAFLD), is a complex, multifactorial disease that progresses via nonalcoholic steatohepatitis (NASH) towards severe liver complications. MAFLD/NAFLD affects up to a third of the global population. It is connected with metabolic syndrome parameters and has been increasing in parallel with the rates of metabolic syndrome parameters worldwide. This disease entity exhibits a strong immune-inflammatory dimension. In MAFLD/NAFLD/NASH, a vast network of innate immune cells is mobilized that can provoke liver damage, leading to advanced fibrosis, cirrhosis and its complications, including hepatocellular carcinoma. However, our understanding of the inflammatory signals that drive the onset and progression of MAFLD/NAFLD/NASH is fragmented. Thus, further investigation is required to better understand the role of specific innate immune cell subsets in the disease, and to aid the design of innovative therapeutic agents to target MAFLD/NAFLD/NASH. In this review, we discuss current concepts regarding the role of innate immune system involvement in MAFLD/NAFLD/NASH onset and progression, along with presenting potential stress signals affecting immune tolerance that may trigger aberrant immune responses. A comprehensive understanding of the innate immune mechanisms involved in MAFLD/NAFLD/NASH pathophysiology will help the discovery of early interventions to prevent the disease, and lead to potential innovative therapeutic strategies that may limit its worldwide burden.
C1 [Kountouras, Jannis; Kazakos, Evangelos; Kyrailidi, Foteini; Zavos, Christos; Arapoglou, Stergios; Mouratidou, Maria C.; Chatzopoulos, Dimitrios; Doulberis, Michael; Papaefthymiou, Apostolis; Vardaka, Elisabeth] Aristotle Univ Thessaloniki, Sch Med, Ippokrat Hosp, Med Clin 2, Macedonia, Greece.
   [Kazakos, Evangelos] Univ West Macedonia, Midwifery Dept, Sch Healthcare Sci, Kozani, Macedonia, Greece.
   [Polyzos, Stergios A.; Doulberis, Michael; Papaefthymiou, Apostolis] Aristotle Univ Thessaloniki, Sch Med, Lab Pharmacol 1, Thessaloniki, Macedonia, Greece.
   [Arapoglou, Stergios] Aristotle Univ Thessaloniki, Med Sch, Ippokrat Hosp, Surg Dept 5, Thessaloniki, Macedonia, Greece.
   [Boziki, Marina] Aristotle Univ Thessaloniki, Sch Med, AHEPA Hosp, Neurol Dept 2,Fac Hlth Sci, Thessaloniki, Macedonia, Greece.
   [Tzitiridou-Chatzopoulou, Maria] Univ West Macedonia, Midwifery Dept, Sch Healthcare Sci, Kozani, Macedonia, Greece.
   [Doulberis, Michael] Univ Zurich, Dept Gastroenterol & Hepatol, Zurich, Switzerland.
   [Papaefthymiou, Apostolis] Univ Coll London Hosp UCLH, Pancreaticobiliary Med Unit, London, England.
   [Vardaka, Elisabeth] Int Hellen Univ, Sch Hlth Sci, Dept Nutr Sci & Dietet, Alexander Campus, Thessaloniki, Macedonia, Greece.
C3 Aristotle University of Thessaloniki; Aristotle University of
   Thessaloniki; Aristotle University of Thessaloniki; Aristotle University
   of Thessaloniki; Ahepa University Hospital; University of Zurich;
   University College London Hospitals NHS Foundation Trust; International
   Hellenic University
RP Kountouras, J (corresponding author), Med, 8 Fanariou St,Byzantio, Thessaloniki 55133, Macedonia, Greece.
EM jannis@auth.gr
RI Boziki, Marina/ACF-8768-2022; VARDAKA, Elisabeth/ABD-1341-2020; Polyzos,
   Stergios/H-2844-2019; Doulberis, Michael/Y-5118-2018; Tzitiridou, Dr.
   Maria/KHW-8314-2024; Papaefthymiou, Apostolis/HPH-4021-2023; Zavos,
   Christos/N-8618-2015
OI Doulberis, Michael/0000-0002-0396-5081; Tzitiridou, Dr.
   Maria/0000-0001-6051-0860; Papaefthymiou, Apostolis/0000-0002-3563-4973;
   Kazakos, Evangelos/0000-0002-3045-720X; Zavos,
   Christos/0000-0002-3443-7791
CR Alic L, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.1010893
   Amiot L, 2019, CYTOKINE, V117, P50, DOI 10.1016/j.cyto.2019.02.002
   Anand PK, 2020, IMMUNOL REV, V297, P108, DOI 10.1111/imr.12891
   Arias-Loste MT, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17111878
   Barranco-Fragoso B, 2022, MED SCI MONITOR, V28, DOI 10.12659/MSM.937528
   Bavia L, 2016, IMMUNOL LETT, V177, P53, DOI 10.1016/j.imlet.2016.07.014
   Bernsmeier C, 2017, J HEPATOL, V66, P1120, DOI 10.1016/j.jhep.2017.02.018
   Bertrand L, 2019, MOL METAB, V27, pS114, DOI 10.1016/j.molmet.2019.06.025
   Boeltz S, 2019, CELL DEATH DIFFER, V26, P395, DOI 10.1038/s41418-018-0261-x
   Bolte FJ, 2018, SEMIN LIVER DIS, V38, P60, DOI 10.1055/s-0037-1621709
   Brandl K, 2017, CURR OPIN GASTROEN, V33, P128, DOI 10.1097/MOG.0000000000000349
   Brenner DA, 2011, HEPATOL RES, V41, P683, DOI 10.1111/j.1872-034X.2011.00814.x
   Cai JJ, 2019, HEPATOLOGY, V70, P1026, DOI 10.1002/hep.30506
   Cai JJ, 2019, ANNU REV PATHOL-MECH, V14, P153, DOI 10.1146/annurev-pathmechdis-012418-013003
   Cai JJ, 2018, TRENDS ENDOCRIN MET, V29, P712, DOI 10.1016/j.tem.2018.08.003
   Canbay A, 2002, GASTROENTEROLOGY, V123, P1323, DOI 10.1053/gast.2002.35953
   Christ A, 2018, CELL, V172, P162, DOI 10.1016/j.cell.2017.12.013
   Cuff AO, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.02180
   Czaja MJ, 2010, TRENDS ENDOCRIN MET, V21, P707, DOI 10.1016/j.tem.2010.08.010
   Daemen S, 2021, CELL REP, V34, DOI 10.1016/j.celrep.2020.108626
   Douhara A, 2015, MOL MED REP, V11, P1693, DOI 10.3892/mmr.2014.2995
   du Plessis J, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0166048
   Fu Y, 2022, MSYSTEMS, V7, DOI 10.1128/msystems.01507-21
   Gatselis NK, 2014, CLIN EXP MED, V14, P121, DOI 10.1007/s10238-012-0227-0
   Gehrke N, 2020, GASTROENTEROLOGY, V158, P1929, DOI 10.1053/j.gastro.2020.02.020
   Gómez-Hurtado I, 2020, LIVER INT, V40, P2182, DOI 10.1111/liv.14571
   Hadinia A, 2019, IRAN J IMMUNOL, V16, P327, DOI [10.22034/IJI.2019.80284, 10.22034/iji.2019.80284]
   Hegde P, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-04450-y
   Heymann F, 2016, NAT REV GASTRO HEPAT, V13, P88, DOI 10.1038/nrgastro.2015.200
   Tran DHY, 2016, INT J OBESITY, V40, P1424, DOI 10.1038/ijo.2016.90
   Huang SZ, 2022, FRONT PHYSIOL, V13, DOI 10.3389/fphys.2022.964887
   Huang W, 2010, DIABETES, V59, P347, DOI 10.2337/db09-0016
   Jeong WI, 2011, HEPATOLOGY, V53, P1342, DOI 10.1002/hep.24190
   Kahraman A, 2010, HEPATOLOGY, V51, P92, DOI 10.1002/hep.23253
   Kar S, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0217263
   Kawaguchi S, 2022, INFLAMMATION, V45, P343, DOI 10.1007/s10753-021-01550-8
   Kennedy L, 2021, HEPATOLOGY, V74, P164, DOI 10.1002/hep.31713
   Kountouras J, 2023, AM J HYPERTENS, V36, P192, DOI 10.1093/ajh/hpac120
   Kountouras J, 2022, METABOLISM, V135, DOI 10.1016/j.metabol.2022.155276
   Kountouras J, 2021, MICROORGANISMS, V9, DOI 10.3390/microorganisms9112351
   Kountouras J, 2020, LIVER INT, V40, P2036, DOI 10.1111/liv.14488
   Kountouras J, 2019, ANN GASTROENTEROL, V32, P214, DOI 10.20524/aog.2019.0349
   Kountouras J, 2016, ANN GASTROENTEROL, V29, P99
   Kountouras J, 2014, MED HYPOTHESES, V82, P368, DOI 10.1016/j.mehy.2013.12.025
   Lee JH, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-23240-6
   Li FL, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms13839
   Li FY, 2020, J PATHOL, V252, P371, DOI 10.1002/path.5531
   Li PW, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22147688
   Li YM, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01994
   Lin SZ, 2022, EBIOMEDICINE, V75, DOI 10.1016/j.ebiom.2021.103768
   Liu J, 2022, CELL BIOSCI, V12, DOI 10.1186/s13578-022-00810-w
   Luci C, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.597648
   Maher JJ, 2008, HEPATOLOGY, V48, P670, DOI 10.1002/hep.22399
   Manco M, 2010, OBES SURG, V20, P1682, DOI 10.1007/s11695-010-0129-8
   Maricic I, 2018, J IMMUNOL, V201, P3017, DOI 10.4049/jimmunol.1800614
   Marrero I, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.02082
   Martínez-Chantar ML, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.640869
   McPherson S, 2015, J HEPATOL, V62, P1148, DOI 10.1016/j.jhep.2014.11.034
   Mikulak J, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.00946
   Morinaga H, 2015, DIABETES, V64, P1120, DOI 10.2337/db14-1238
   Nati M, 2022, J INNATE IMMUN, V14, P31, DOI 10.1159/000518407
   Nati M, 2016, REV ENDOCR METAB DIS, V17, P29, DOI 10.1007/s11154-016-9339-2
   O'Hara J, 2020, JHEP REP, V2, DOI 10.1016/j.jhepr.2020.100142
   Polyzos SA, 2019, HELICOBACTER, V24, DOI 10.1111/hel.12588
   Polyzos SA, 2015, METABOLISM, V64, P60, DOI 10.1016/j.metabol.2014.10.012
   Rensen SS, 2009, HEPATOLOGY, V50, P1809, DOI 10.1002/hep.23228
   Schuster S, 2018, NAT REV GASTRO HEPAT, V15, P349, DOI 10.1038/s41575-018-0009-6
   Schwabe RF, 2020, J HEPATOL, V72, P230, DOI 10.1016/j.jhep.2019.08.016
   Segers FM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0110053
   Spits H, 2013, NAT REV IMMUNOL, V13, P145, DOI 10.1038/nri3365
   Su DM, 2016, FRONT PHYSIOL, V7, DOI 10.3389/fphys.2016.00498
   Su L, 2019, CELL IMMUNOL, V337, P33, DOI 10.1016/j.cellimm.2019.01.005
   Sun GY, 2018, CELL REP, V25, P3786, DOI 10.1016/j.celrep.2018.12.006
   Tajiri K, 2012, INT J HEPATOL, V2012, DOI 10.1155/2012/850836
   Takai S, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21207543
   Takeuchi O, 2010, CELL, V140, P805, DOI 10.1016/j.cell.2010.01.022
   Talukdar S, 2012, NAT MED, V18, P1407, DOI 10.1038/nm.2885
   Tian ZG, 2013, HEPATOLOGY, V57, P1654, DOI 10.1002/hep.26115
   Tilg H, 2020, NAT REV IMMUNOL, V20, P40, DOI 10.1038/s41577-019-0198-4
   Torres-Hernandez A, 2020, HEPATOLOGY, V71, P477, DOI 10.1002/hep.30952
   Tosello-Trampont AC, 2016, HEPATOLOGY, V63, P799, DOI 10.1002/hep.28389
   van der Windt DJ, 2018, HEPATOLOGY, V68, P1347, DOI 10.1002/hep.29914
   Vong LD, 2016, INFLAMM BOWEL DIS, V22, P42, DOI 10.1097/MIB.0000000000000591
   Wang XL, 2020, HEPATOLOGY, V71, P408, DOI 10.1002/hep.31025
   Warner JB, 2022, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.812882
   Weiskirchen R, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8111429
   Wirtz TH, 2019, INT REV CEL MOL BIO, V348, P263, DOI 10.1016/bs.ircmb.2019.08.001
   Xu CF, 2016, SCI REP-UK, V6, DOI 10.1038/srep23279
   Xu RN, 2014, CELL MOL IMMUNOL, V11, P224, DOI 10.1038/cmi.2014.2
   Yang G, 2016, SCI REP-UK, V6, DOI 10.1038/srep24399
   Younossi ZM, 2018, HEPATOLOGY, V68, P361, DOI 10.1002/hep.29724
   Yuan LY, 2022, AM J GASTROENTEROL, V117, P433, DOI 10.14309/ajg.0000000000001591
   Yuan M, 2022, LIFE-BASEL, V12, DOI 10.3390/life12101532
   Yuk JM, 2009, CELL HOST MICROBE, V6, P231, DOI 10.1016/j.chom.2009.08.004
   Zhang YF, 2022, MOL MED REP, V25, DOI 10.3892/mmr.2021.12529
   Zhao GN, 2017, NAT MED, V23, P742, DOI 10.1038/nm.4334
   Zhao JB, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.1054159
   Zhou D, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-01751-y
   Zhou Z, 2018, CELL MOL GASTROENTER, V5, P399, DOI 10.1016/j.jcmgh.2018.01.003
   Zoabi Y, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10102486
NR 100
TC 14
Z9 14
U1 4
U2 12
PU HELLENIC SOC GASTROENTEROLOGY
PI ATHENS
PA DEMOKRATIAS AVE 67, ATHENS, 15451, GREECE
SN 1108-7471
EI 1792-7463
J9 ANN GASTROENTEROL
JI Ann. Gastroenterol.
PY 2023
VL 36
IS 3
BP 244
EP 256
DI 10.20524/aog.2023.0793
PG 13
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA H4QX2
UT WOS:000995836800002
PM 37144011
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sao, R
   Aronow, WS
AF Sao, Rahul
   Aronow, Wilbert S.
TI Association of non-alcoholic fatty liver disease with cardiovascular
   disease and subclinical atherosclerosis
SO ARCHIVES OF MEDICAL SCIENCE
LA English
DT Article
DE non-alcoholic fatty liver disease; coronary artery disease;
   atherosclerotic cardiovascular disease
ID CORONARY-ARTERY-DISEASE; ANKLE VASCULAR INDEX; INTIMA-MEDIA THICKNESS;
   HEPATIC INSULIN-RESISTANCE; TYPE-2 DIABETES-MELLITUS; METABOLIC
   SYNDROME; BARIATRIC SURGERY; CAROTID ATHEROSCLEROSIS; COLLATERAL
   CIRCULATION; SYSTEMIC INFLAMMATION
AB Non-alcoholic fatty liver disease (NAFLD) refers to fatty infiltration of liver in the absence of significant alcohol intake, use of steatogenic medication, or hereditary disorders. It is a common cause of chronic liver disease with a worldwide estimated prevalence ranging from 6.3% to 33%. The NAFLD is considered a hepatic manifestation of the metabolic syndrome. Insulin resistance and increased oxidative stress are central to pathogenesis of NAFLD, and risk factors include metabolic syndrome, diabetes mellitus, obesity, lack of physical activity, smoking, and high fat diet. NAFLD is associated with higher mortality as compared to the general population with cardiovascular disease being the most common cause of death. The NAFLD is associated with a higher prevalence of subclinical atherosclerosis as evidenced by odds of higher coronary artery calcification, higher average and maximum carotid intima-media thickness. It is also associated with stiff arteries as evidenced by higher cardio-ankle vascular index and higher brachial-ankle pulse wave velocity. Increasing evidence has linked NAFLD with atherosclerotic cardiovascular diseases. The NAFLD is associated with a higher prevalence of coronary artery disease (CAD), more severe CAD, poor coronary collateral development, and higher incidence of coronary events. The NAFLD is also associated with ischemic stroke. Studies have shown that the association between NAFLD and atherosclerotic cardiovascular diseases is independent of shared risk factors.
C1 [Sao, Rahul; Aronow, Wilbert S.] New York Med Coll, Westchester Med Ctr, Dept Med, Cardiol Div, Valhalla, NY 10595 USA.
C3 Westchester Medical Center; New York Medical College
RP Aronow, WS (corresponding author), New York Med Coll, Cardiol Div, Macy Pavil,Room 141, Valhalla, NY 10595 USA.
EM wsaronow@aol.com
CR Açikel M, 2009, ANATOL J CARDIOL, V9, P273
   Adams LA, 2005, GASTROENTEROLOGY, V129, P113, DOI 10.1053/j.gastro.2005.04.014
   Agarwal A K, 2011, J Assoc Physicians India, V59, P351
   Aithal GP, 2008, GASTROENTEROLOGY, V135, P1176, DOI 10.1053/j.gastro.2008.06.047
   Al Rifai M, 2015, ATHEROSCLEROSIS, V239, P629, DOI 10.1016/j.atherosclerosis.2015.02.011
   Almeda-Valdés P, 2009, ANN HEPATOL, V8, pS18, DOI 10.1016/S1665-2681(19)31822-8
   Alper AT, 2008, TURK KARDIYOL DERN A, V36, P376
   Amaro A, 2010, GASTROENTEROLOGY, V139, P149, DOI 10.1053/j.gastro.2010.03.039
   Ampuero J, 2015, REV ESP ENFERM DIG, V107, P10
   Angulo P, 2007, HEPATOLOGY, V45, P846, DOI 10.1002/hep.21496
   Armstrong MJ, 2016, LANCET, V387, P679, DOI 10.1016/S0140-6736(15)00803-X
   Arslan U, 2012, J CARDIOL, V60, P210, DOI 10.1016/j.jjcc.2012.05.003
   Assy N, 2000, DIGEST DIS SCI, V45, P1929, DOI 10.1023/A:1005661516165
   Bae JC, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046819
   Baffy G, 2012, J HEPATOL, V56, P1384, DOI 10.1016/j.jhep.2011.10.027
   Banach M, 2015, LIPIDS HEALTH DIS, V14, DOI 10.1186/s12944-015-0169-0
   BECKNIELSEN H, 1979, ACTA ENDOCRINOL-COP, V90, P103, DOI 10.1530/acta.0.0900103
   Bhatia LS, 2012, EUR HEART J, V33, P1190, DOI 10.1093/eurheartj/ehr453
   Bower G, 2015, EUR J GASTROEN HEPAT, V27, P755, DOI 10.1097/MEG.0000000000000375
   Bugianesi E, 2005, DIABETOLOGIA, V48, P634, DOI 10.1007/s00125-005-1682-x
   Bugianesi E, 2005, AM J GASTROENTEROL, V100, P1082, DOI 10.1111/j.1572-0241.2005.41583.x
   CATURELLI E, 1992, J GASTROEN HEPATOL, V7, P469, DOI 10.1111/j.1440-1746.1992.tb01022.x
   Chalasani N, 2012, AM J GASTROENTEROL, V107, P811, DOI 10.1038/ajg.2012.128
   Charlton M, 2004, CLIN GASTROENTEROL H, V2, P1048, DOI 10.1016/S1542-3565(04)00440-9
   Chavaez-Tapia NC, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007340.pub2
   Chiarelli F, 2008, VASC HEALTH RISK MAN, V4, P297
   Choudhary NS, 2015, J CLIN EXP HEPATOL, V5, P123, DOI 10.1016/j.jceh.2015.04.002
   Chung GE, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000000654
   Courrèges JP, 2008, DIABETIC MED, V25, P1129, DOI 10.1111/j.1464-5491.2008.02484.x
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   de Keyser CE, 2014, DIGEST LIVER DIS, V46, P720, DOI 10.1016/j.dld.2014.04.002
   Fargion S, 2014, WORLD J GASTROENTERO, V20, P13306, DOI 10.3748/wjg.v20.i37.13306
   Furuya CK, 2007, J GASTROEN HEPATOL, V22, P510, DOI 10.1111/j.1440-1746.2007.04833.x
   Gaggini M, 2013, NUTRIENTS, V5, P1544, DOI 10.3390/nu5051544
   Greenland P, 2007, J AM COLL CARDIOL, V49, P378, DOI 10.1016/j.jacc.2006.10.001
   Hamaguchi M, 2005, ANN INTERN MED, V143, P722, DOI 10.7326/0003-4819-143-10-200511150-00009
   Hamaguchi M, 2007, WORLD J GASTROENTERO, V13, P1579, DOI 10.3748/wjg.v13.i10.1579
   HANSEN JF, 1989, AM HEART J, V117, P290, DOI 10.1016/0002-8703(89)90771-0
   Haukeland JW, 2006, J HEPATOL, V44, P1167, DOI 10.1016/j.jhep.2006.02.011
   Hossain N, 2016, GASTROENT RES PRACT, V2016, DOI 10.1155/2016/7109270
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Huang MA, 2005, AM J GASTROENTEROL, V100, P1072, DOI 10.1111/j.1572-0241.2005.41334.x
   Huang Y, 2012, ARTERIOSCL THROM VAS, V32, P2321, DOI 10.1161/ATVBAHA.112.252957
   Hui JM, 2004, HEPATOLOGY, V40, P46, DOI 10.1002/hep.20280
   Idilman IS, 2015, J DIABETES, V7, P279, DOI 10.1111/1753-0407.12172
   Idilman R, 2008, ALIMENT PHARM THER, V28, P200, DOI 10.1111/j.1365-2036.2008.03723.x
   Izuhara M, 2008, CIRC J, V72, P1762, DOI 10.1253/circj.CJ-08-0152
   Johnsen Stein Harald, 2009, Curr Cardiol Rep, V11, P21
   Kahn BB, 2000, J CLIN INVEST, V106, P473, DOI 10.1172/JCI10842
   Kang Ji Hoon, 2012, J Cardiovasc Ultrasound, V20, P126, DOI 10.4250/jcu.2012.20.3.126
   Kantartzis K, 2009, DIABETES, V58, P2616, DOI 10.2337/db09-0279
   Kim HC, 2009, ATHEROSCLEROSIS, V204, P521, DOI 10.1016/j.atherosclerosis.2008.09.012
   Kiyici M, 2003, CAN J GASTROENTEROL, V17, P713, DOI 10.1155/2003/857869
   Kornowski R, 2003, CORONARY ARTERY DIS, V14, P61, DOI 10.1097/00019501-200302000-00007
   Kwak MS, 2015, LIVER INT, V35, P944, DOI 10.1111/liv.12552
   Leite NC, 2009, LIVER INT, V29, P113, DOI 10.1111/j.1478-3231.2008.01718.x
   Li N, 2015, NUTR METAB CARDIOVAS, V25, P218, DOI 10.1016/j.numecd.2014.10.002
   Li Y, 2013, BIOMED REP, V1, P57, DOI 10.3892/br.2012.18
   LONG SD, 1994, DIABETES CARE, V17, P372, DOI 10.2337/diacare.17.5.372
   Machado M, 2006, J HEPATOL, V45, P600, DOI 10.1016/j.jhep.2006.06.013
   Marchesini G, 2001, LANCET, V358, P893, DOI 10.1016/S0140-6736(01)06042-1
   Mathurin P, 2009, GASTROENTEROLOGY, V137, P532, DOI 10.1053/j.gastro.2009.04.052
   Milic S, 2014, WORLD J GASTROENTERO, V20, P9330, DOI 10.3748/wjg.v20.i28.9330
   Moshayedi H, 2014, IRAN J NEUROL, V13, P144
   Nakamoto K, 2016, YAKUGAKU ZASSHI, V136, P583, DOI 10.1248/yakushi.15-00264-4
   Nakamura K, 2008, CIRC J, V72, P598
   Oliveira CP, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/4597246
   Ong JP, 2008, J HEPATOL, V49, P608, DOI 10.1016/j.jhep.2008.06.018
   Pan XL, 2015, ENDOCRINE, V48, P834, DOI 10.1007/s12020-014-0384-x
   Petersen KF, 2005, DIABETES, V54, P603, DOI 10.2337/diabetes.54.3.603
   Pisto P, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2014-004973
   Poanta LI, 2011, MED ULTRASON, V13, P215
   Ratziu V, 2008, GASTROENTEROLOGY, V135, P100, DOI 10.1053/j.gastro.2008.03.078
   Ratziu V, 2010, HEPATOLOGY, V51, P445, DOI 10.1002/hep.23270
   Rizvi AA, 2015, EXPERT OPIN BIOL TH, V15, P1391, DOI 10.1517/14712598.2015.1067299
   Saadeh S, 2002, GASTROENTEROLOGY, V123, P745, DOI 10.1053/gast.2002.35354
   Saiki A, 2016, J ATHEROSCLER THROMB, V23, P155, DOI 10.5551/jat.32797
   Samy Waleed, 2011, Arab J Gastroenterol, V12, P80, DOI 10.1016/j.ajg.2011.04.008
   Santos RD, 2007, ATHEROSCLEROSIS, V194, P517, DOI 10.1016/j.atherosclerosis.2007.01.026
   Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929
   Saponaro C, 2015, CURR DIABETES REP, V15, DOI 10.1007/s11892-015-0607-4
   Shields William W, 2009, Therap Adv Gastroenterol, V2, P157, DOI 10.1177/1756283X09105462
   Shirai K, 2011, J ATHEROSCLER THROMB, V18, P924
   Sonmez A, 2015, J CLIN LIPIDOL, V9, P576, DOI 10.1016/j.jacl.2015.03.010
   Sun L, 2011, CHINESE MED J-PEKING, V124, P867, DOI 10.3760/cma.j.issn.0366-6999.2011.06.012
   Sung KC, 2012, DIABETES CARE, V35, P2359, DOI 10.2337/dc12-0515
   Suzuki J, 2013, J STROKE CEREBROVASC, V22, P171, DOI 10.1016/j.jstrokecerebrovasdis.2011.07.010
   SWINBURN BA, 1993, ANN NY ACAD SCI, V683, P102
   Targher G, 2005, DIABETES, V54, P3541, DOI 10.2337/diabetes.54.12.3541
   Targher G, 2005, ARTERIOSCL THROM VAS, V25, P2687, DOI 10.1161/01.ATV.0000189299.61568.79
   Targher G, 2005, ARTERIOSCL THROM VAS, V25, pE117, DOI 10.1161/01.ATV.0000170132.91268.a2
   Thakur ML, 2012, ATHEROSCLEROSIS, V223, P507, DOI 10.1016/j.atherosclerosis.2012.06.005
   Tilg H, 2010, HEPATOLOGY, V52, P1836, DOI 10.1002/hep.24001
   Tilg H, 2010, DIGEST DIS, V28, P179, DOI 10.1159/000282083
   Uysal KT, 1997, NATURE, V389, P610, DOI 10.1038/39335
   VanWagner LB, 2014, ATHEROSCLEROSIS, V235, P599, DOI 10.1016/j.atherosclerosis.2014.05.962
   Vernon G, 2011, ALIMENT PHARM THER, V34, P274, DOI 10.1111/j.1365-2036.2011.04724.x
   Videla LA, 2004, FREE RADICAL BIO MED, V37, P1499, DOI 10.1016/j.freeradbiomed.2004.06.033
   Villanova N, 2005, HEPATOLOGY, V42, P473, DOI 10.1002/hep.20781
   Visser ME, 2011, DIABETOLOGIA, V54, P2113, DOI 10.1007/s00125-011-2157-x
   Wang CC, 2009, J GASTROEN HEPATOL, V24, P1411, DOI 10.1111/j.1440-1746.2009.05872.x
   Whalley S, 2007, CLIN MED, V7, P119, DOI 10.7861/clinmedicine.7-2-119
   Wieckowska A, 2008, AM J GASTROENTEROL, V103, P1372, DOI 10.1111/j.1572-0241.2007.01774.x
   Wieckowska A, 2006, HEPATOLOGY, V44, P27, DOI 10.1002/hep.21223
   Wiedemann MSF, 2013, AM J PHYSIOL-ENDOC M, V305, pE388, DOI 10.1152/ajpendo.00179.2013
   Wong VWS, 2011, GUT, V60, P1721, DOI 10.1136/gut.2011.242016
   Yilmaz Y, 2012, ALIMENT PHARM THER, V36, P815, DOI 10.1111/apt.12046
   Ying I, 2011, EPIDEMIOLOGY, V22, P129, DOI 10.1097/EDE.0b013e3181feb50a
   Yu XY, 2014, J ZHEJIANG UNIV-SC B, V15, P879, DOI 10.1631/jzus.B1400028
   Zhang Chaoxian, 2015, Wei Sheng Yan Jiu, V44, P730
   Zhang Chaoxian, 2014, Wei Sheng Yan Jiu, V43, P724
   Zhang Chaoxian, 2014, Nan Fang Yi Ke Da Xue Xue Bao, V34, P1481
   Zhao LN, 2015, CLIN SCI, V129, P1025, DOI 10.1042/CS20150143
NR 113
TC 38
Z9 43
U1 0
U2 7
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1734-1922
EI 1896-9151
J9 ARCH MED SCI
JI Arch. Med. Sci.
PD OCT
PY 2018
VL 14
IS 6
BP 1233
EP 1244
DI 10.5114/aoms.2017.68821
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GX8NY
UT WOS:000448045000004
PM 30393477
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ferramosca, A
   Conte, A
   Moscatelli, N
   Zara, V
AF Ferramosca, A.
   Conte, A.
   Moscatelli, N.
   Zara, V.
TI A high-fat diet negatively affects rat sperm mitochondrial respiration
SO ANDROLOGY
LA English
DT Article
DE High-fat diet; male infertility; metabolic syndrome; sperm mitochondria
ID METABOLIC SYNDROME; OXIDATIVE STRESS; GLYCOLYSIS PLAYS; HORMONE-LEVELS;
   SEMEN QUALITY; INFERTILITY; DEHYDROGENASES; SPERMATOZOA; FERTILITY;
   FLAGELLUM
AB Recent evidences have linked abdominal obesity, insulin resistance, and dyslipidemia to male infertility. Since a defective energy metabolism may play an important role in the impairment of sperm quality, the aim of this study is to investigate the sperm energetic metabolism in rats fed with a high-fat diet, an animal model associated with metabolic syndrome development. Sexually mature male Sprague-Dawley rats were divided into two groups and fed for 4weeks a standard diet (control group) or a diet enriched in 35% of fat (high fat group). Liver and adipose tissue weight, plasma glucose, insulin, and lipid concentrations were determined. Activities of enzymes involved in sperm energetic metabolism were evaluated by spectrophotometric assays. Sperm mitochondrial respiratory activity was evaluated with a polarographic assay of oxygen consumption. The administration of a high-fat diet caused a significant increase in body weight of rats and provoked hyperglycemia, hyperinsulinemia, and dyslipidemia. In these animals, we also observed a reduction in sperm concentration and motility. The investigation of sperm energetic metabolism in animals fed a high-fat diet revealed an impairment in the activity of pyruvate and lactate dehydrogenase, citrate synthase, and respiratory chain complexes. A parallel reduction in the cellular levels of adenosine triphosphate (ATP) and an increase in oxidative damage were also observed. A defective energy metabolism may play an important role in the impairment of sperm quality in the high-fat diet fed rats.
C1 [Ferramosca, A.; Conte, A.; Moscatelli, N.; Zara, V.] Univ Salento, Dipartimento Sci & Tecnol Biol Ambientali, Via Prov Lecce Monteroni, I-73100 Lecce, Italy.
C3 University of Salento
RP Ferramosca, A (corresponding author), Univ Salento, Dipartimento Sci & Tecnol Biol Ambientali, Via Prov Lecce Monteroni, I-73100 Lecce, Italy.
EM alessandra.ferramosca@unisalento.it
RI Zara, Vincenzo/AAC-2900-2019; Ferramosca, Alessandra/B-8801-2015
OI MOSCATELLI, NATALINA/0000-0002-9291-9588; Zara,
   Vincenzo/0000-0001-6592-4501; Ferramosca, Alessandra/0000-0002-8251-9652
FU Fondazione Cassa di Risparmio di Puglia
FX This research was financially supported by Fondazione Cassa di Risparmio
   di Puglia, regarding the project 'Obesita e infertilita maschile: ruolo
   degli acidi grassi nella modulazione del metabolismo energetico degli
   spermatozoi'.
CR Asrih M, 2015, MOL CELL ENDOCRINOL, V418, P55, DOI 10.1016/j.mce.2015.02.018
   Bachir BG, 2014, UROL CLIN N AM, V41, P67, DOI 10.1016/j.ucl.2013.08.008
   BLANCO A, 1963, SCIENCE, V139, P601, DOI 10.1126/science.139.3555.601
   Bobjer J, 2012, INT J ANDROL, V35, P688, DOI 10.1111/j.1365-2605.2012.01277.x
   BURGOS C, 1995, BIOL REPROD, V53, P84, DOI 10.1095/biolreprod53.1.84
   Christe M., 2013, ISRN OBES, V2013
   Dias TR, 2014, MOL CELL ENDOCRINOL, V396, P37, DOI 10.1016/j.mce.2014.08.005
   du Plessis SS, 2015, ASIAN J ANDROL, V17, P230, DOI 10.4103/1008-682X.135123
   Ferramosca A, 2008, INT J ANDROL, V31, P337, DOI 10.1111/j.1365-2605.2007.00775.x
   Ferramosca A, 2015, UROLOGY, V86, P735, DOI 10.1016/j.urology.2015.07.011
   Ferramosca A, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/645984
   Ferramosca A, 2014, EUR J NUTR, V53, P1103, DOI 10.1007/s00394-013-0613-8
   Ferramosca A, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/902953
   Ferramosca A, 2014, WORLD J GASTROENTERO, V20, P1746, DOI 10.3748/wjg.v20.i7.1746
   Ferramosca A, 2013, UROLOGY, V82, P78, DOI 10.1016/j.urology.2013.03.058
   Ferramosca A, 2012, UROLOGY, V79, P809, DOI 10.1016/j.urology.2011.12.042
   Ford WCL, 2006, HUM REPROD UPDATE, V12, P269, DOI 10.1093/humupd/dmi053
   GOLDBERG E, 1963, SCIENCE, V139, P602, DOI 10.1126/science.139.3555.602
   Hagiuda J, 2014, ANDROLOGIA, V46, P131, DOI 10.1111/and.12057
   HASSAN AA, 1993, J UROLOGY, V149, P148, DOI 10.1016/S0022-5347(17)36028-7
   Jahangir E, 2014, TRANSL RES, V164, P336, DOI 10.1016/j.trsl.2014.03.010
   Kasturi SS, 2008, J ANDROL, V29, P251, DOI 10.2164/jandrol.107.003731
   Leisegang K, 2014, REPROD BIOL ENDOCRIN, V12, DOI 10.1186/1477-7827-12-34
   Meeker JD, 2007, J ANDROL, V28, P397, DOI 10.2164/jandrol.106.001545
   Morrison CD, 2015, BEST PRACT RES CL OB, V29, P507, DOI 10.1016/j.bpobgyn.2014.10.006
   Mukai C, 2004, BIOL REPROD, V71, P540, DOI 10.1095/biolreprod.103.026054
   Piasecka M, 2001, ANDROLOGIA, V33, P1, DOI 10.1046/j.1439-0272.2001.00369.x
   Piomboni P, 2012, INT J ANDROL, V35, P109, DOI 10.1111/j.1365-2605.2011.01218.x
   Davila MP, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0138777
   Lancellotti TES, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013457
   SEETHALAKSHMI L, 1987, J UROLOGY, V138, P190, DOI 10.1016/S0022-5347(17)43042-4
   Shalaby MA, 2004, PHARMACOL RES, V50, P137, DOI 10.1016/j.phrs.2003.10.013
   Starkov AA, 1997, BBA-BIOENERGETICS, V1318, P173, DOI 10.1016/S0005-2728(96)00135-1
   Takei GL, 2014, J EXP BIOL, V217, P1876, DOI 10.1242/jeb.090985
   Tremellen K, 2008, HUM REPROD UPDATE, V14, P243, DOI 10.1093/humupd/dmn004
   Yoo HJ, 2015, DIABETES METAB J, V39, P10, DOI 10.4093/dmj.2015.39.1.10
   Zhao J, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/190945
NR 37
TC 49
Z9 52
U1 0
U2 29
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-2919
EI 2047-2927
J9 ANDROLOGY-US
JI Andrology
PD MAY
PY 2016
VL 4
IS 3
BP 520
EP 525
DI 10.1111/andr.12182
PG 6
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DL8HG
UT WOS:000375881200021
PM 27062222
OA Bronze
DA 2025-06-11
ER

PT J
AU Berkovic, MC
   Virovic-Jukic, L
   Bilic-Curcic, I
   Mrzljak, A
AF Cigrovski Berkovic, Maja
   Virovic-Jukic, Lucija
   Bilic-Curcic, Ines
   Mrzljak, Anna
TI Post-transplant diabetes mellitus and preexisting liver disease-a
   bidirectional relationship affecting treatment and management
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Diabetes mellitus; Liver transplantation; Non-alcoholic fatty liver
   disease; Metabolic syndrome; Insulin-resistance; Glucagon-like peptide-1
   receptor agonists; Sodium-glucose cotransporter 2 inhibitors
ID HEPATITIS-C VIRUS; SERUM URIC-ACID; LAPAROSCOPIC SLEEVE GASTRECTOMY;
   RENAL-TRANSPLANT RECIPIENTS; PEPTIDE-1 RECEPTOR AGONISTS; CHRONIC
   KIDNEY-DISEASE; INSULIN-RESISTANCE; NONALCOHOLIC STEATOHEPATITIS;
   CARDIOVASCULAR-DISEASE; RISK-FACTORS
AB Liver cirrhosis and diabetes mellitus (DM) are both common conditions with significant socioeconomic burden and impact on morbidity and mortality. A bidirectional relationship exists between DM and liver cirrhosis regarding both etiology and disease-related complications. Type 2 DM (T2DM) is a well-recognized risk factor for chronic liver disease and vice-versa, DM may develop as a complication of cirrhosis, irrespective of its etiology. Liver transplantation (LT) represents an important treatment option for patients with end-stage liver disease due to non-alcoholic fatty liver disease (NAFLD), which represents a hepatic manifestation of metabolic syndrome and a common complication of T2DM. The metabolic risk factors including immunosuppressive drugs, can contribute to persistent orde novodevelopment of DM and NAFLD after LT. T2DM, obesity, cardiovascular morbidities and renal impairment, frequently associated with metabolic syndrome and NAFLD, may have negative impact on short and long-term outcomes following LT. The treatment of DM in the context of chronic liver disease and post-transplant is challenging, but new emerging therapies such as glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT2i) targeting multiple mechanisms in the shared pathophysiology of disorders such as oxidative stress and chronic inflammation are a promising tool in future patient management.
C1 [Cigrovski Berkovic, Maja] Univ Zagreb, Fac Kinesiol, Dept Kinesiol Anthropol & Methodol, Zagreb 10000, Croatia.
   [Cigrovski Berkovic, Maja] Clin Hosp Dubrava, Zagreb 10000, Croatia.
   [Cigrovski Berkovic, Maja; Bilic-Curcic, Ines] Univ JJ Strossmayer Osijek, Fac Med, Dept Pharmacol, Osijek 31000, Croatia.
   [Virovic-Jukic, Lucija; Bilic-Curcic, Ines; Mrzljak, Anna] Univ Zagreb, Sch Med, Salata 3b, Zagreb 10000, Croatia.
   [Virovic-Jukic, Lucija] Sisters Char Univ Hosp, Dept Med, Div Gastroenterol & Hepatol, Zagreb 10000, Croatia.
   [Bilic-Curcic, Ines] Clin Hosp Ctr Osijek, Osijek 31000, Croatia.
   [Mrzljak, Anna] Merkur Univ Hosp, Dept Med, Zagreb 10000, Croatia.
C3 University of Zagreb; University of Zagreb, Faculty of Kinesiology;
   University of Zagreb; University of JJ Strossmayer Osijek; University of
   Zagreb
RP Mrzljak, A (corresponding author), Univ Zagreb, Sch Med, Salata 3b, Zagreb 10000, Croatia.
EM anna.mrzljak@mef.hr
RI Cigrovski Berkovic, Maja/AAB-7735-2019; Mrzljak, Anna/J-7465-2017;
   Curcic, Ines/R-6013-2018
OI Cigrovski Berkovic, Maja/0000-0003-0750-9785
CR Adams LA, 2017, GUT, V66, P1138, DOI 10.1136/gutjnl-2017-313884
   Adams LA, 2009, AM J GASTROENTEROL, V104, P861, DOI 10.1038/ajg.2009.67
   ADAMS PC, 1991, AM J MED, V90, P445
   Afolabi BI, 2018, J NATL MED ASSOC, V110, P256, DOI 10.1016/j.jnma.2017.06.001
   Akuta N, 2017, HEPATOL COMMUN, V1, P46, DOI 10.1002/hep4.1019
   Al Rifai M, 2015, ATHEROSCLEROSIS, V239, P629, DOI 10.1016/j.atherosclerosis.2015.02.011
   [Anonymous], 2016, GLOBAL REPORT DIABET
   Anstee QM, 2013, NAT REV GASTRO HEPAT, V10, P330, DOI 10.1038/nrgastro.2013.41
   Armstrong MJ, 2013, ALIMENT PHARM THER, V37, P234, DOI 10.1111/apt.12149
   Armstrong MJ, 2014, HEPATOLOGY, V59, P1174, DOI 10.1002/hep.26717
   Armstrong MJ, 2016, LANCET, V387, P679, DOI 10.1016/S0140-6736(15)00803-X
   Beckmann S, 2017, CLIN TRANSPLANT, P31
   Beckmann S, 2018, TRANSPL INT, V31, P1254, DOI 10.1111/tri.13308
   Bedossa P, 2018, LIVER INT, V38, P64, DOI 10.1111/liv.13653
   Bernsmeier C, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0087488
   Bertolani Cristiana, 2008, Pathophysiology, V15, P91, DOI 10.1016/j.pathophys.2008.05.001
   Bhagat V, 2009, LIVER TRANSPLANT, V15, P1814, DOI 10.1002/lt.21927
   Bouchi R, 2017, ENDOCR J, V64, P269, DOI 10.1507/endocrj.EJ16-0449
   Bray GA, 2016, LANCET, V387, P1947, DOI 10.1016/S0140-6736(16)00271-3
   Buzzetti E, 2016, METABOLISM, V65, P1038, DOI 10.1016/j.metabol.2015.12.012
   Cai CX, 2015, EXP THER MED, V10, P693, DOI 10.3892/etm.2015.2537
   Cariou B, 2015, DIABETES METAB, V41, P252, DOI 10.1016/j.diabet.2014.10.004
   Chalasani NP, 2017, HEPATOLOGY, V66, p303A
   Cholankeril G, 2017, DIGEST DIS SCI, V62, P2915, DOI 10.1007/s10620-017-4684-x
   Contos MJ, 2001, LIVER TRANSPLANT, V7, P363, DOI 10.1053/jlts.2001.23011
   de Mesquita FC, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-02866-y
   Cusi K, 2018, DIABETIC MED, V35, P1434, DOI 10.1111/dme.13697
   Cusi K, 2016, ANN INTERN MED, V165, P305, DOI 10.7326/M15-1774
   Cusi K, 2016, DIABETOLOGIA, V59, P1112, DOI 10.1007/s00125-016-3952-1
   D'Amico E, 2005, J MOL ENDOCRINOL, V34, P377, DOI 10.1677/jme.1.01655
   Darmawan G, 2017, ACTA MED INDONES, V49, P136
   de Marco R, 1999, DIABETES CARE, V22, P756, DOI 10.2337/diacare.22.5.756
   De Minicis S, 2013, CURR PHARM DESIGN, V19, P5239
   Di Maira T, 2015, LIVER TRANSPLANT, V21, P812, DOI 10.1002/lt.24128
   Dong YJ, 2017, CLIN RES HEPATOL GAS, V41, P284, DOI 10.1016/j.clinre.2016.11.009
   Dureja P, 2011, TRANSPLANTATION, V91, P684, DOI 10.1097/TP.0b013e31820b6b84
   Duvnjak M, 2007, WORLD J GASTROENTERO, V13, P4539, DOI 10.3748/wjg.v13.i34.4539
   EASL, 2016, OBESITY FACTS, V9, P65, DOI [10.1159/000443344, 10.1007/s00125-016-3902-y, 10.1016/j.jhep.2015.11.004]
   Eguchi Y, 2015, HEPATOL RES, V45, P269, DOI 10.1111/hepr.12351
   Eriksson JW, 2018, DIABETOLOGIA, V61, P1923, DOI 10.1007/s00125-018-4675-2
   Everhart JE, 1998, LIVER TRANSPLANT SUR, V4, P285, DOI 10.1002/lt.500040402
   Fan H, 2013, ARQ BRAS ENDOCRINOL, V57, P702, DOI 10.1590/S0004-27302013000900005
   Feng WH, 2019, J DIABETES INVEST, V10, P399, DOI 10.1111/jdi.12888
   Flisiak R, 2000, CYTOKINE, V12, P677, DOI 10.1006/cyto.1999.0660
   Galindo RJ, 2016, CURR DIABETES REP, V16, DOI 10.1007/s11892-015-0707-1
   García-Compeán D, 2014, WORLD J GASTROENTERO, V20, P7011, DOI 10.3748/wjg.v20.i22.7011
   Garcia-Compean D, 2009, WORLD J GASTROENTERO, V15, P280, DOI 10.3748/wjg.15.280
   Garvey WT, 2018, METABOLISM, V85, P32, DOI 10.1016/j.metabol.2018.02.002
   Germani G, 2019, TRANSPLANTATION, V103, P57, DOI 10.1097/TP.0000000000002485
   Gerstein HC, 2019, LANCET, V394, P121, DOI 10.1016/S0140-6736(19)31149-3
   Gluud LL, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2014-005325
   Goldberg D, 2017, GASTROENTEROLOGY, V152, P1090, DOI 10.1053/j.gastro.2017.01.003
   Grancini V, 2019, J HEPATOL, V70, P954, DOI 10.1016/j.jhep.2019.01.015
   Greco AV, 2002, GUT, V51, P870, DOI 10.1136/gut.51.6.870
   Guariguata L, 2014, DIABETES RES CLIN PR, V103, P137, DOI 10.1016/j.diabres.2013.11.002
   Gupta NA, 2010, HEPATOLOGY, V51, P1584, DOI 10.1002/hep.23569
   Halden TAS, 2016, DIABETES CARE, V39, P617, DOI 10.2337/dc15-2383
   Halden TAS, 2019, DIABETES CARE, V42, P1067, DOI 10.2337/dc19-0093
   Hazlehurst JM, 2016, METABOLISM, V65, P1096, DOI 10.1016/j.metabol.2016.01.001
   Hedrington MS, 2019, EXPERT OPIN PHARMACO, V20, P133, DOI 10.1080/14656566.2018.1552258
   Heimbach JK, 2013, AM J TRANSPLANT, V13, P363, DOI 10.1111/j.1600-6143.2012.04318.x
   Heise T, 2013, DIABETES OBES METAB, V15, P613, DOI 10.1111/dom.12073
   Helderman JH, 2002, J AM SOC NEPHROL, V13, P277, DOI 10.1681/ASN.V131277
   Hernandez AF, 2018, LANCET, V392, P1519, DOI 10.1016/S0140-6736(18)32261-X
   Holstein A, 2002, J GASTROEN HEPATOL, V17, P677, DOI 10.1046/j.1440-1746.2002.02755.x
   Honda F, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0195028
   Hu MY, 2017, BIOCHIMIE, V143, P37, DOI 10.1016/j.biochi.2017.10.019
   Hurren KM, 2012, ANN PHARMACOTHER, V46, P710, DOI 10.1345/aph.1Q583
   Ito D, 2017, DIABETES CARE, V40, P1364, DOI 10.2337/dc17-0518
   Jendle J, 2009, DIABETES OBES METAB, V11, P1163, DOI 10.1111/j.1463-1326.2009.01158.x
   Jin J, 2017, AM J TRANSPLANT, V17, P2601, DOI 10.1111/ajt.14316
   Jonsson JR, 2005, J HEPATOL, V43, P929, DOI 10.1016/j.jhep.2005.05.030
   Kalogirou M, 2018, WORLD J HEPATOL, V10, P790, DOI 10.4254/wjh.v10.i11.790
   Kashyap R, 2001, TRANSPLANT P, V33, P1482, DOI 10.1016/S0041-1345(00)02561-6
   Kawaguchi T, 2011, WORLD J HEPATOL, V3, P99, DOI 10.4254/wjh.v3.i5.99
   Khoraki J, 2016, SURG OBES RELAT DIS, V12, P75, DOI 10.1016/j.soard.2015.04.002
   Kralj D, 2016, J CLIN TRANSL HEPATO, V4, P66, DOI 10.14218/JCTH.2015.00051
   KRUSZYNSKA YT, 1991, HEPATOLOGY, V14, P103, DOI 10.1002/hep.1840140117
   Kuchay MS, 2018, DIABETES CARE, V41, P1801, DOI 10.2337/dc18-0165
   Kuo HT, 2010, TRANSPLANTATION, V89, P1134, DOI 10.1097/TP.0b013e3181d2fec1
   Lee WG, 2019, DIABETES-METAB RES, V35, DOI 10.1002/dmrr.3157
   Lee YH, 2016, MOLECULES, V21, DOI 10.3390/molecules21111424
   Leiter LA, 2016, DIABETES METAB, V42, P25, DOI 10.1016/j.diabet.2015.10.003
   LETIEXHE MR, 1993, J CLIN ENDOCR METAB, V77, P1263, DOI 10.1210/jc.77.5.1263
   Li CI, 2015, INT J CANCER, V136, P2668, DOI 10.1002/ijc.29321
   Li Y, 2013, BIOMED REP, V1, P57, DOI 10.3892/br.2012.18
   Lieber SR, 2019, CLIN TRANSPLANT, V33, DOI 10.1111/ctr.13554
   Lin MYC, 2013, SURG OBES RELAT DIS, V9, P653, DOI 10.1016/j.soard.2013.02.013
   Lin MYC, 2013, SURG ENDOSC, V27, P81, DOI 10.1007/s00464-012-2410-5
   Liou JH, 2018, TRANSPL P, V50, P2502, DOI 10.1016/j.transproceed.2018.03.087
   Lv CY, 2015, J DIABETES, V7, P881, DOI 10.1111/1753-0407.12275
   Mantovani A, 2018, METABOLISM, V79, P64, DOI 10.1016/j.metabol.2017.11.003
   Mantovani A, 2017, J DIABETES COMPLICAT, V31, P1021, DOI 10.1016/j.jdiacomp.2017.01.024
   Marcuccilli M, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17040562
   Marso SP, 2016, NEW ENGL J MED, V375, P311, DOI 10.1056/NEJMoa1603827
   Mehta SH, 2000, ANN INTERN MED, V133, P592, DOI 10.7326/0003-4819-133-8-200010170-00009
   Milman N, 2001, ANN HEMATOL, V80, P737, DOI 10.1007/s002770100371
   Morbitzer KA, 2014, CLIN TRANSPLANT, V28, P862, DOI 10.1111/ctr.12391
   Mosko JD, 2011, CLIN GASTROENTEROL H, V9, P897, DOI 10.1016/j.cgh.2011.07.007
   Muir CA, 2017, J HEART LUNG TRANSPL, V36, P914, DOI 10.1016/j.healun.2017.05.005
   Munagala MR, 2016, MED CLIN N AM, V100, P519, DOI 10.1016/j.mcna.2016.01.004
   Musso G, 2014, PLOS MED, V11, DOI 10.1371/journal.pmed.1001680
   Narayanan P, 2019, TRANSPLANTATION, V103, pe14, DOI 10.1097/TP.0000000000002317
   Neal B, 2017, NEW ENGL J MED, V377, P644, DOI 10.1056/NEJMoa1611925
   Newsome P, 2019, ALIMENT PHARM THER, V50, P193, DOI 10.1111/apt.15316
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Ohki T, 2012, SCI WORLD J, DOI 10.1100/2012/496453
   Olubamwo OO, 2018, EUR J GASTROEN HEPAT, V30, P1047, DOI 10.1097/MEG.0000000000001183
   Orsi E, 2017, LIVER INT, V37, P950, DOI 10.1111/liv.13337
   Pais R, 2016, J HEPATOL, V65, P1245, DOI 10.1016/j.jhep.2016.07.033
   Park SK, 2013, HEPATOLOGY, V57, P1378, DOI 10.1002/hep.26183
   Peláez-Jaramillo MJ, 2018, DIABETES THER, V9, P521, DOI 10.1007/s13300-018-0374-8
   Petit JM, 2017, J CLIN ENDOCR METAB, V102, P407, DOI 10.1210/jc.2016-2775
   Petit JM, 2001, J HEPATOL, V35, P279, DOI 10.1016/S0168-8278(01)00143-X
   Petrides AS, 1998, HEPATOLOGY, V28, P141, DOI 10.1002/hep.510280119
   Pinelli NR, 2013, DIABETES CARE, V36, pE171, DOI 10.2337/dc13-1066
   Pratley R, 2019, LANCET, V394, P39, DOI 10.1016/S0140-6736(19)31271-1
   Rajasekeran H, 2017, DIABETES CARE, V40, pE75, DOI 10.2337/dc17-0237
   Rao NN, 2018, SEMIN NEPHROL, V38, P291, DOI 10.1016/j.semnephrol.2018.02.008
   Anastácio LR, 2012, NUTR HOSP, V27, P1351, DOI 10.3305/nh.2012.27.4.5768
   Richards J, 2005, TRANSPL INT, V18, P461, DOI 10.1111/j.1432-2277.2004.00067.x
   Roden M, 2006, NAT CLIN PRACT ENDOC, V2, P335, DOI 10.1038/ncpendmet0190
   Rubín A, 2013, TRANSPL INT, V26, P740, DOI 10.1111/tri.12118
   Saffo Saad, 2018, Clin Liver Dis (Hoboken), V11, P141, DOI 10.1002/cld.714
   Saliba F, 2007, LIVER TRANSPLANT, V13, P136, DOI 10.1002/lt.21010
   Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929
   Sattar N, 2018, DIABETOLOGIA, V61, P2155, DOI 10.1007/s00125-018-4702-3
   Scheen AJ, 2018, ANN TRANSL MED, V6, DOI 10.21037/atm.2018.10.39
   Seko Y, 2017, HEPATOL RES, V47, P1206, DOI 10.1111/hepr.12837
   Sharif A, 2014, AM J TRANSPLANT, V14, P1992, DOI 10.1111/ajt.12850
   Shibata M, 2007, DIABETES CARE, V30, P2940, DOI 10.2337/dc07-0792
   Shimizu M, 2019, DIABETES OBES METAB, V21, P285, DOI 10.1111/dom.13520
   Shivaswamy V, 2016, ENDOCR REV, V37, P37, DOI 10.1210/er.2015-1084
   Smiri-Duvnjak L, 2018, GASTROINTESTINAL COM, P3
   Snyder HS, 2018, J CLIN TRANSL HEPATO, V6, P168, DOI 10.14218/JCTH.2017.00050
   Stojsavljevic S, 2014, WORLD J GASTROENTERO, V20, P18070, DOI 10.3748/wjg.v20.i48.18070
   Sumida Y, 2018, J GASTROENTEROL, V53, P362, DOI 10.1007/s00535-017-1415-1
   Sun F, 2015, CLIN THER, V37, P225, DOI 10.1016/j.clinthera.2014.11.008
   Svegliati-Baroni G, 1999, HEPATOLOGY, V29, P1743, DOI 10.1002/hep.510290632
   Takata MC, 2008, SURG OBES RELAT DIS, V4, P159, DOI 10.1016/j.soard.2007.12.009
   Tang A, 2015, DIABETES CARE, V38, P1339, DOI 10.2337/dc14-2548
   Targher G, 2008, DIABETOLOGIA, V51, P444, DOI 10.1007/s00125-007-0897-4
   Targher G, 2014, AM J KIDNEY DIS, V64, P638, DOI 10.1053/j.ajkd.2014.05.019
   Tsochatzis EA, 2014, LANCET, V383, P1749, DOI 10.1016/S0140-6736(14)60121-5
   Vallin M, 2014, LIVER TRANSPLANT, V20, P1064, DOI 10.1002/lt.23936
   van Raalte DH, 2011, DIABETES CARE, V34, P412, DOI 10.2337/dc10-1677
   van Son J, 2020, METABOLISM, V106, DOI 10.1016/j.metabol.2020.154204
   Veldt BJ, 2009, AM J TRANSPLANT, V9, P1406, DOI 10.1111/j.1600-6143.2009.02642.x
   Virovic-Jukic L, 2018, GASTROINTESTINAL COM
   Wang CG, 2012, INT J CANCER, V130, P1639, DOI 10.1002/ijc.26165
   Wang CC, 2020, ALIMENT PHARM THER, V51, P216, DOI 10.1111/apt.15575
   Wei M, 2000, DIABETES CARE, V23, P18, DOI 10.2337/diacare.23.1.18
   White DL, 2008, J HEPATOL, V49, P831, DOI 10.1016/j.jhep.2008.08.006
   Whitehead JP, 2006, DIABETES OBES METAB, V8, P264, DOI 10.1111/j.1463-1326.2005.00510.x
   Wiviott SD, 2019, NEW ENGL J MED, V380, P347, DOI [10.1056/NEJMoa1812389, 10.1056/NEJMc1902837]
   Xu C, 2019, MED SCI MONITOR, V25, P8112, DOI 10.12659/MSM.917000
   Yan JH, 2019, HEPATOLOGY, V69, P2414, DOI 10.1002/hep.30320
   Yen FS, 2020, LIVER INT, V40, P1089, DOI 10.1111/liv.14385
   Yilmaz Y, 2012, ALIMENT PHARM THER, V36, P815, DOI 10.1111/apt.12046
   Younossi ZM, 2015, HEPATOLOGY, V62, p739A, DOI 10.1002/hep.28431
   Zelniker TA, 2019, LANCET, V393, P31, DOI 10.1016/S0140-6736(18)32590-X
   Zhao YM, 2018, DIABETES OBES METAB, V20, P458, DOI 10.1111/dom.13101
   Zhou YJ, 2016, CLIN BIOCHEM, V49, P636, DOI 10.1016/j.clinbiochem.2015.12.010
   Zinman B, 2015, NEW ENGL J MED, V373, P2117, DOI 10.1056/NEJMoa1504720
NR 164
TC 11
Z9 11
U1 0
U2 3
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD JUN 7
PY 2020
VL 26
IS 21
BP 2740
EP 2757
DI 10.3748/wjg.v26.i21.2740
PG 18
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA LZ3WB
UT WOS:000541157700006
PM 32550751
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Moreira, ALG
   Silva, PHF
   Salvador, SL
   Ishikawa, KH
   Ferreira, GC
   Tanus-Santos, JE
   Mayer, MPA
   de Souza, SLS
   Furlaneto, FAC
   Messora, MR
AF Moreira, Andre L. G.
   Silva, Pedro H. F.
   Salvador, Sergio L.
   Ishikawa, Karin H.
   Ferreira, Graziele C.
   Tanus-Santos, Jose E.
   Mayer, Marcia P. A.
   de Souza, Sergio L. S.
   Furlaneto, Flavia A. C.
   Messora, Michel R.
TI Effects of probiotics in rats with experimental metabolic syndrome and
   periodontitis: An investigation of the intestine-adipose tissue axis
SO JOURNAL OF PERIODONTOLOGY
LA English
DT Article
DE metabolic syndrome; periodontitis; probiotics
ID FATTY LIVER-DISEASE; OXIDATIVE STRESS; ASSOCIATION; LACTIS;
   INFLAMMATION; EXPRESSION; THERAPY; LIPIDS; MODEL
AB BackgroundThis study evaluated the systemic (intestine and adipose tissue) and local (periodontal tissues) impact of probiotic therapy in rats with metabolic syndrome (MS) associated or not with periodontitis (PE). MethodsForty-eight rats received a high-fat diet for induction of MS for 16 weeks. They were subdivided into groups with (+) and without (-) PE, receiving (*) or not (**) receiving probiotics (PROB): MS (-**), MSP (-*), MSPE (+**), and MSPEP (+*). PROB administration (Bifidobacterium animalis subsp. lactis HN019) started on the 8th week of the study and PE was induced on the 14th week by placing ligature on the animals' lower first molars. Euthanasia occurred in the 16th week. Biomolecular, immunoenzymatic assays, and histomorphometric analyses were performed. The data obtained were statistically analyzed (ANOVA, Tukey, p < 0.05). ResultsThe MSPEP group exhibited reduced alveolar bone loss when compared with the MSPE group, as well as lower levels of hepatic steatosis and proteinuria (p < 0.05). In the intestinal environment, the MSPE group exhibited significantly lower villus height and crypt depth, as well as a greater increase in Bacillota when compared with the MSPEP group (p < 0.05). The MSPEP group showed lower adipokine gene expression (LEPR, NAMPT, and FABP4) in adipose tissue than the MSPE group (p < 0.05). ConclusionThe probiotic B. lactis HN019 reduced the severity of experimental periodontitis and modulated the expression of lipogenic genes and intestinal morphological and microbiological parameters in rats with MS.
C1 [Moreira, Andre L. G.; Silva, Pedro H. F.; de Souza, Sergio L. S.; Furlaneto, Flavia A. C.; Messora, Michel R.] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Oral & Maxillofacial Surg & Periodontol, Ribeirao Preto, SP, Brazil.
   [Salvador, Sergio L.] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Clin Anal, Ribeirao Preto, SP, Brazil.
   [Ishikawa, Karin H.; Mayer, Marcia P. A.] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo, Brazil.
   [Ferreira, Graziele C.; Tanus-Santos, Jose E.] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, Ribeirao Preto, SP, Brazil.
   [Furlaneto, Flavia A. C.] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Oral & Maxillofacial Surg & Periodontol, Ave Cafe s-n Ribeirao Preto-SP14020 150, Ribeirao Preto, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade de
   Sao Paulo; Institute Biomed Science, University Sao Paulo; Universidade
   de Sao Paulo; Universidade de Sao Paulo
RP Furlaneto, FAC (corresponding author), Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Oral & Maxillofacial Surg & Periodontol, Ave Cafe s-n Ribeirao Preto-SP14020 150, Ribeirao Preto, SP, Brazil.
EM flafurlaneto@usp.br
RI Ferreira, Graziele/D-9011-2018; Furlaneto, Flavia/C-4171-2013; Salvador,
   Sergio/G-1015-2019; de Souza, Sergio/F-8803-2014; Messora,
   Michel/F-3480-2012; Felix Silva, Pedro Henrique/S-2286-2019; Mayer,
   Marcia/D-4645-2012
OI Salvador, Sergio Luiz/0000-0002-4867-7294; ISHIKAWA,
   KARIN/0000-0003-3926-3572; Felix Silva, Pedro
   Henrique/0000-0002-7583-7046; Mayer, Marcia/0000-0002-5910-8433
FU Sao Paulo Research Foundation [2017/26257-9, 2018/16009-0]
FX Sao Paulo Research Foundation,Grant/Award Numbers: FAPESP -Funding
   2017/26257-9, 2018/16009-0
CR Andriankaja OM, 2010, AUST DENT J, V55, P252, DOI 10.1111/j.1834-7819.2010.01231.x
   Attaye I, 2022, GASTROENTEROLOGY, V162, P1911, DOI 10.1053/j.gastro.2022.02.011
   Ausenda F, 2023, JPN DENT SCI REV, V59, P62, DOI 10.1016/j.jdsr.2023.02.001
   Lourenço TGB, 2018, J ORAL MICROBIOL, V10, DOI 10.1080/20002297.2018.1487741
   Bernini LJ, 2018, BRIT J NUTR, V120, P645, DOI 10.1017/S0007114518001861
   Bernini LJ, 2016, NUTRITION, V32, P716, DOI 10.1016/j.nut.2015.11.001
   Cardoso RS, 2020, BENEF MICROBES, V11, P33, DOI 10.3920/BM2019.0038
   Chakaroun RM, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041082
   Chen XP, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1104-3
   Cheng J, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.790561
   Dai YL, 2022, RENAL FAILURE, V44, P862, DOI 10.1080/0886022X.2022.2079522
   Damanaki A, 2014, MEDIAT INFLAMM, V2014, DOI 10.1155/2014/912821
   de Oliveira AM, 2022, J PERIODONTOL, V93, P31, DOI 10.1002/JPER.21-0078
   de Oliveira LFF, 2023, J PERIODONTOL, V94, P217, DOI 10.1002/JPER.21-0555
   Deng XL, 2019, EUR J NUTR, V58, P2713, DOI 10.1007/s00394-018-1821-z
   Deng YF, 2010, ANN NY ACAD SCI, V1212, pE1, DOI 10.1111/j.1749-6632.2010.05875.x
   Dogan B, 2022, PROBIOTICS ANTIMICRO, V14, P114, DOI 10.1007/s12602-021-09803-6
   Dubinkina VB, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0359-2
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   El-Zahar KM, 2021, J NUTR METAB, V2021, DOI 10.1155/2021/1557945
   Forner L, 2006, J CLIN PERIODONTOL, V33, P401, DOI 10.1111/j.1600-051X.2006.00924.x
   GIRARD J, 1994, FASEB J, V8, P36, DOI 10.1096/fasebj.8.1.7905448
   Gomes IS, 2021, CLIN ORAL INVEST, V25, P3719, DOI 10.1007/s00784-020-03699-2
   Guo X, 2008, LETT APPL MICROBIOL, V47, P367, DOI 10.1111/j.1472-765X.2008.02408.x
   Hajishengallis G, 2012, MOL ORAL MICROBIOL, V27, P409, DOI 10.1111/j.2041-1014.2012.00663.x
   Hajishengallis G, 2021, NAT REV IMMUNOL, V21, P426, DOI 10.1038/s41577-020-00488-6
   Han WF, 2011, MOL CELL BIOCHEM, V347, P13, DOI 10.1007/s11010-010-0607-2
   Hill C, 2014, NAT REV GASTRO HEPAT, V11, P506, DOI 10.1038/nrgastro.2014.66
   Invernici MM, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0238425
   Invernici MM, 2018, J CLIN PERIODONTOL, V45, P1198, DOI 10.1111/jcpe.12995
   Jaramillo A, 2017, CLIN ORAL INVEST, V21, P1537, DOI 10.1007/s00784-016-1942-9
   Jepsen S, 2020, PERIODONTOL 2000, V83, P125, DOI 10.1111/prd.12326
   Jiang WW, 2015, SCI REP-UK, V5, DOI 10.1038/srep08096
   Jung YunSook, 2023, Int J Environ Res Public Health, V20, DOI 10.3390/ijerph20032533
   Kim DJ, 2019, J DENT RES, V98, P1511, DOI 10.1177/0022034519880824
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Kuraji R, 2023, WORLD J GASTROENTERO, V29, P967, DOI 10.3748/wjg.v29.i6.967
   Lamster IB, 2017, INT DENT J, V67, P67, DOI 10.1111/idj.12264
   Large V, 2004, DIABETES METAB, V30, P294, DOI 10.1016/S1262-3636(07)70121-0
   Li G, 2019, J PERIODONTAL RES, V54, P356, DOI 10.1111/jre.12636
   Lin HP, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0035240, 10.1371/journal.pone.0031286]
   Carreras NL, 2018, BENEF MICROBES, V9, P629, DOI [10.3920/BM2017.0141, 10.3920/bm2017.0141]
   Luo S, 2016, J PERIODONTAL RES, V51, P453, DOI 10.1111/jre.12322
   Maldonado-Gómez MX, 2016, CELL HOST MICROBE, V20, P515, DOI 10.1016/j.chom.2016.09.001
   Mantovani A, 2022, GUT, V71, P156, DOI 10.1136/gutjnl-2020-323082
   Messora MR, 2013, J PERIODONTOL, V84, P1818, DOI 10.1902/jop.2013.120644
   Musazadeh V, 2022, EUR J PHARMACOL, V928, DOI 10.1016/j.ejphar.2022.175069
   Nibali L, 2013, J CLIN ENDOCR METAB, V98, P913, DOI 10.1210/jc.2012-3552
   Nicolucci AC, 2017, GASTROENTEROLOGY, V153, P711, DOI 10.1053/j.gastro.2017.05.055
   Ohnishi T, 2009, J PERIODONTAL RES, V44, P43, DOI 10.1111/j.1600-0765.2007.01060.x
   Oliveira LFF, 2017, J PERIODONTOL, V88, P197, DOI 10.1902/jop.2016.160217
   Ondee T, 2022, NUTRIENTS, V14, DOI 10.3390/nu14010080
   Park KH, 2017, EXP MOL MED, V49, DOI 10.1038/emm.2017.116
   Patel D, 2022, MEDIAT INFLAMM, V2022, DOI 10.1155/2022/4230599
   Plaza-Diaz J, 2019, ADV NUTR, V10, pS49, DOI 10.1093/advances/nmy063
   Rinttilä T, 2004, J APPL MICROBIOL, V97, P1166, DOI 10.1111/j.1365-2672.2004.02409.x
   Rizzo M, 2012, CELL STRESS CHAPERON, V17, P399, DOI 10.1007/s12192-011-0315-1
   Rosário-dos-Santos HL, 2023, ORAL DIS, V29, P2512, DOI 10.1111/odi.14428
   Silva GA, 2022, J PERIODONTOL, V93, pE1, DOI 10.1002/JPER.21-0285
   Targher G, 2017, NAT REV NEPHROL, V13, P297, DOI 10.1038/nrneph.2017.16
   Tenorio-Jiménez C, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010124
   Torres S, 2019, EUR J NUTR, V58, P27, DOI 10.1007/s00394-018-1790-2
   Torumtay G, 2016, J PERIODONTAL RES, V51, P489, DOI 10.1111/jre.12328
   Vives-Soler A, 2020, MED ORAL PATOL ORAL, V25, pE161, DOI 10.4317/medoral.23147
   Wang D, 2008, ORAL MICROBIOL IMMUN, V23, P401, DOI 10.1111/j.1399-302X.2008.00442.x
   Wang JJ, 2015, ISME J, V9, P1, DOI 10.1038/ismej.2014.99
   Wang ZB, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/3862971
   Younossi ZM, 2005, HEPATOLOGY, V42, P665, DOI 10.1002/hep.20838
NR 68
TC 1
Z9 1
U1 2
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3492
EI 1943-3670
J9 J PERIODONTOL
JI J. Periodont.
PD NOV
PY 2023
VL 94
IS 11
BP 1363
EP 1375
DI 10.1002/JPER.22-0721
EA MAY 2023
PG 13
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA Y2SH2
UT WOS:000991868700001
PM 37057371
DA 2025-06-11
ER

PT J
AU McPherson, KC
   Shields, CA
   Poudel, B
   Fizer, B
   Pennington, A
   Szabo-Johnson, A
   Thompson, WL
   Cornelius, DC
   Williams, JM
AF McPherson, Kasi C.
   Shields, Corbin A.
   Poudel, Bibek
   Fizer, Brianca
   Pennington, Alyssa
   Szabo-Johnson, Ashley
   Thompson, Willie L.
   Cornelius, Denise C.
   Williams, Jan M.
TI Impact of obesity as an independent risk factor for the development of
   renal injury: implications from rat models of obesity
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Review
DE high-fat diet; leptin; metabolic syndrome; obesity; renal disease
ID DIET-INDUCED OBESITY; CHRONIC KIDNEY-DISEASE; SPONTANEOUSLY
   HYPERTENSIVE-RATS; INITIATED METABOLIC SYNDROME; SYMPATHETIC-NERVE
   ACTIVITY; SALT-SENSITIVE RATS; BODY-MASS INDEX; HIGH-FAT; OXIDATIVE
   STRESS; BLOOD-PRESSURE
AB Diabetes and hypertension are the major causes of chronic kidney disease (CKD). Epidemiological studies within the last few decades have revealed that obesity-associated renal disease is an emerging epidemic and that the increasing prevalence of obesity parallels the increased rate of CKD. This has led to the inclusion of obesity as an independent risk factor for CKD. A major complication when studying the relationship between obesity and renal injury is that cardiovascular and metabolic disorders that may result from obesity including hyperglycemia, hypertension, and dyslipidemia, or the cluster of these disorders [defined as the metabolic syndrome, (MetS)] also contribute to the development and progression of renal disease. The associations between hyperglycemia and hypertension with renal disease have been reported extensively in patients suffering from obesity. Currently, there are several obese rodent models (high-fat diet-induced obesity and leptin signaling dysfunction) that exhibit characteristics of MetS. However, the available obese rodent models currently have not been used to investigate the impact of obesity alone on the development of renal injury before hypertension and/ or hyperglycemia. Therefore, the aim of this review is to describe the incidence and severity of renal disease in these rodent models of obesity and determine which models are suitable to study the independent effects obesity on the development and progression of renal disease.
C1 [McPherson, Kasi C.; Shields, Corbin A.; Poudel, Bibek; Fizer, Brianca; Pennington, Alyssa; Szabo-Johnson, Ashley; Thompson, Willie L.; Cornelius, Denise C.; Williams, Jan M.] Univ Mississippi, Med Ctr, Dept Pharmacol & Toxicol, 2500 North State St, Jackson, MS 39219 USA.
   [Cornelius, Denise C.] Univ Mississippi, Med Ctr, Dept Emergency Med, Jackson, MS 39216 USA.
C3 University of Mississippi Medical Center; University of Mississippi;
   University of Mississippi Medical Center; University of Mississippi
RP Williams, JM (corresponding author), Univ Mississippi, Med Ctr, Dept Pharmacol & Toxicol, 2500 North State St, Jackson, MS 39219 USA.
EM jmwilliams5@umc.edu
OI Cornelius, Denise/0000-0002-6730-6499; Poudel, Dr.
   Bibek/0000-0003-1353-7002
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [1F31-DK-109571, DK-109133]; National Heart, Lung, and Blood Institute
   [HL-130456]; National Institute of General Medical Sciences (Obesity,
   Cardiorenal and Metabolic Diseases-COBRE) [P20-GM-104357, GM-115428]
FX This work was financially supported by the National Institute of
   Diabetes and Digestive and Kidney Diseases Grants 1F31-DK-109571 (to K.
   C. McPherson) and DK-109133 (to J. M. Williams) and National Heart,
   Lung, and Blood Institute Grant HL-130456 and National Institute of
   General Medical Sciences (Obesity, Cardiorenal and Metabolic
   Diseases-COBRE) Grants P20-GM-104357 (to D. C. Cornelius) and GM-115428
   supported summer undergraduate students (to A. Pennington and B. Fizer)
   and P20-GM-104357 (to J. M. Williams).
CR Abdullah A, 2016, GLOBAL HEALTH ACTION, V9, DOI 10.3402/gha.v9.30421
   AlonsoGalicia M, 1996, HYPERTENSION, V28, P1047, DOI 10.1161/01.HYP.28.6.1047
   Auberval N, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-130
   Bäckhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   Bagby SP, 2004, J AM SOC NEPHROL, V15, P2775, DOI 10.1097/01.ASN.0000141965.28037.EE
   Beyer AM, 2012, HYPERTENSION, V60, P404, DOI 10.1161/HYPERTENSIONAHA.112.191551
   Bilan VP, 2011, J ENDOCRINOL, V210, P293, DOI 10.1530/JOE-11-0122
   Bloor ID, 2012, HYPERTENSION, V60, P991, DOI 10.1161/HYPERTENSIONAHA.112.195412
   Boustany-Kari CM, 2016, J PHARMACOL EXP THER, V356, P712, DOI 10.1124/jpet.115.230706
   Bravo PE, 2006, VASC HEALTH RISK MAN, V2, P163, DOI 10.2147/vhrm.2006.2.2.163
   BRAY GA, 1979, PHYSIOL REV, V59, P719, DOI 10.1152/physrev.1979.59.3.719
   BRYCE GF, 1977, HORM METAB RES, V9, P366, DOI 10.1055/s-0028-1093529
   Cai XJ, 2000, MOL BRAIN RES, V77, P131, DOI 10.1016/S0169-328X(00)00041-3
   Cao J, 2012, OBESITY, V20, P945, DOI 10.1038/oby.2011.365
   Chagnac A, 2000, AM J PHYSIOL-RENAL, V278, pF817, DOI 10.1152/ajprenal.2000.278.5.F817
   Chagnac A, 2003, J AM SOC NEPHROL, V14, P1480, DOI 10.1097/01.ASN.0000068462.38661.89
   Chen HM, 2006, AM J KIDNEY DIS, V48, P772, DOI 10.1053/j.ajkd.2006.07.025
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Chertow GM, 2006, J AM SOC NEPHROL, V17, P1501, DOI 10.1681/ASN.2006040327
   Chua SC, 1996, DIABETES, V45, P1141, DOI 10.2337/diabetes.45.8.1141
   Chueakula N, 2018, FREE RADICAL BIO MED, V115, P146, DOI 10.1016/j.freeradbiomed.2017.11.021
   Chung HW, 2012, NEPHROL DIAL TRANSPL, V27, P2213, DOI 10.1093/ndt/gfr613
   CLARK JB, 1983, P SOC EXP BIOL MED, V173, P68
   Clause B T, 1998, Mendel Newsl, P2
   Coimbra TM, 2000, KIDNEY INT, V57, P167, DOI 10.1046/j.1523-1755.2000.00836.x
   Corsetti JP, 2000, ATHEROSCLEROSIS, V148, P231, DOI 10.1016/S0021-9150(99)00265-8
   Cosson E, 2009, DIABETES METAB, V35, P364, DOI 10.1016/j.diabet.2009.02.007
   D'Angelo G, 2006, HYPERTENSION, V48, P1109, DOI 10.1161/01.HYP.0000247306.53547.d4
   DAHL LK, 1962, J EXP MED, V115, P1173, DOI 10.1084/jem.115.6.1173
   Danda RS, 2005, KIDNEY INT, V68, P2562, DOI 10.1111/j.1523-1755.2005.00727.x
   Daniels A, 2012, EUR J HEART FAIL, V14, P193, DOI 10.1093/eurjhf/hfr166
   Declèves AE, 2014, KIDNEY INT, V85, P1474, DOI 10.1038/ki.2014.100
   Declèves AE, 2011, J AM SOC NEPHROL, V22, P1846, DOI 10.1681/ASN.2011010026
   Dobrian AD, 2001, HYPERTENSION, V37, P554, DOI 10.1161/01.HYP.37.2.554
   Dobrian AD, 2004, HYPERTENSION, V43, P48, DOI 10.1161/01.HYP.0000103629.01745.59
   Dobrian AD, 2000, HYPERTENSION, V35, P1009, DOI 10.1161/01.HYP.35.4.1009
   Dominguez JH, 2006, KIDNEY INT, V69, P1969, DOI 10.1038/sj.ki.5000406
   Ejerblad E, 2006, J AM SOC NEPHROL, V17, P1695, DOI 10.1681/ASN.2005060638
   Elmarakby AA, 2010, CLIN SCI, V118, P291, DOI 10.1042/CS20090395
   Ernsberger P, 1999, ANN NY ACAD SCI, V892, P272, DOI 10.1111/j.1749-6632.1999.tb07801.x
   Ernsberger P, 2007, AM J HYPERTENS, V20, P866, DOI 10.1016/j.amjhyper.2007.02.015
   Fenske WK, 2013, SURG OBES RELAT DIS, V9, P559, DOI 10.1016/j.soard.2012.03.009
   Friedman AN, 2014, AM J NEPHROL, V39, P8, DOI 10.1159/000357231
   Friedman JE, 1997, AM J PHYSIOL-ENDOC M, V273, pE1014, DOI 10.1152/ajpendo.1997.273.5.E1014
   Frisbee JC, 2005, MICROCIRCULATION, V12, P383, DOI 10.1080/10739680590960241
   Gades MD, 1999, KIDNEY INT, V56, P1779, DOI 10.1046/j.1523-1755.1999.00731.x
   Gallo LA, 2015, DIABETES VASC DIS RE, V12, P78, DOI 10.1177/1479164114561992
   Gelber RP, 2005, AM J KIDNEY DIS, V46, P871, DOI 10.1053/j.ajkd.2005.08.015
   Geurts AM, 2010, METHODS MOL BIOL, V597, P211, DOI 10.1007/978-1-60327-389-3_15
   Geurts AM, 2009, SCIENCE, V325, P433, DOI 10.1126/science.1172447
   Griffin KA, 2007, AM J PHYSIOL-RENAL, V293, pF1605, DOI 10.1152/ajprenal.00511.2006
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Hall JE, 2004, ADV RENAL REPLACE TH, V11, P41, DOI 10.1053/j.arrt.2003.10.007
   Hall JE, 2002, AM J MED SCI, V324, P127, DOI 10.1097/00000441-200209000-00003
   Hattori T, 2011, NUTR DIABETES, V1, DOI 10.1038/nutd.2010.1
   Hattori T, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.114.001312
   He J, 2017, METAB SYNDR RELAT D, V15, P344, DOI 10.1089/met.2017.0057
   Henegar JR, 2001, J AM SOC NEPHROL, V12, P1211, DOI 10.1681/ASN.V1261211
   HENNES MMI, 1990, DIABETES, V39, P789, DOI 10.2337/diabetes.39.7.789
   Heyen JRR, 2002, AM J PHYSIOL-HEART C, V283, pH1775, DOI 10.1152/ajpheart.00305.2002
   Hoshi S, 2002, LAB INVEST, V82, P25, DOI 10.1038/labinvest.3780392
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Imam TH, 2017, AM J KIDNEY DIS, V69, P380, DOI 10.1053/j.ajkd.2016.09.020
   IONESCU E, 1985, AM J PHYSIOL, V248, pE500, DOI 10.1152/ajpendo.1985.248.5.E500
   Ishizaka N, 2007, HYPERTENS RES, V30, P1059, DOI 10.1291/hypres.30.1059
   Jin CH, 2014, J PHARMACOL EXP THER, V351, P467, DOI 10.1124/jpet.114.215566
   Jin CH, 2014, CLIN EXP PHARMACOL P, V41, P579, DOI 10.1111/1440-1681.12250
   Jose B, 2013, OBES SURG, V23, P634, DOI 10.1007/s11695-012-0851-5
   Kanauchi M, 2006, NEPHROL DIAL TRANSPL, V21, P3608, DOI 10.1093/ndt/gfl435
   Kelley R, 2013, CELL TRANSPLANT, V22, P1023, DOI 10.3727/096368912X653237
   Khan MAH, 2014, CARDIOVASC DRUG THER, V28, P313, DOI 10.1007/s10557-014-6530-0
   Khan MAH, 2011, AM J HYPERTENS, V24, P816, DOI 10.1038/ajh.2011.34
   Khan SA, 2017, ACTA PHYSIOL, V221, P250, DOI 10.1111/apha.12891
   Khan SA, 2015, ACTA PHYSIOL, V214, P390, DOI 10.1111/apha.12499
   Knight SF, 2008, HYPERTENSION, V51, P352, DOI 10.1161/HYPERTENSIONAHA.107.099499
   Knight SF, 2010, AM J PHYSIOL-RENAL, V298, pF86, DOI 10.1152/ajprenal.00351.2009
   KOLETSKY S, 1973, EXP MOL PATHOL, V19, P53, DOI 10.1016/0014-4800(73)90040-3
   Komura Hiroshi, 2013, BMC Res Notes, V6, P463, DOI 10.1186/1756-0500-6-463
   Kramer HJ, 2006, J AM SOC NEPHROL, V17, P1453, DOI 10.1681/ASN.2005111241
   Kuhlmann J, 2003, DIABETES, V52, P138, DOI 10.2337/diabetes.52.1.138
   Kurella M, 2005, J AM SOC NEPHROL, V16, P2134, DOI 10.1681/ASN.2005010106
   Lando SK, 2010, RENAL DIS TECHNIQUES
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Linz D, 2015, AM J HYPERTENS, V28, P256, DOI 10.1093/ajh/hpu123
   Machado Hussen, 2012, J Bras Nefrol, V34, P328
   Maric C, 2011, CONTRIB NEPHROL, V170, P28, DOI 10.1159/000324941
   Marques C, 2016, ADIPOCYTE, V5, P11, DOI 10.1080/21623945.2015.1061723
   Matsuura N, 2015, INT J CARDIOL, V179, P360, DOI 10.1016/j.ijcard.2014.11.099
   Mauvais-Jarvis F, 2015, BIOL SEX DIFFER, V6, DOI 10.1186/s13293-015-0033-y
   MCCALEB ML, 1992, METABOLISM, V41, P522, DOI 10.1016/0026-0495(92)90212-S
   McCune SA, 1990, ILAR NEWS, V32, P23, DOI DOI 10.1093/ILAR.32.3.23
   McPherson KC, 2016, AM J PHYSIOL-RENAL, V311, pF793, DOI 10.1152/ajprenal.00590.2015
   MICHAELIS OE, 1984, AM J CLIN NUTR, V39, P612, DOI 10.1093/ajcn/39.4.612
   Mohanan A, 2011, INT J HYPERTENS, V2011, DOI 10.4061/2011/751513
   Montani JP, 2002, INT J OBESITY, V26, pS28, DOI 10.1038/sj.ijo.0802125
   Mostafa DK, 2017, EUR J PHARMACOL, V806, P110, DOI 10.1016/j.ejphar.2017.03.020
   Nagae A, 2009, CLIN EXP HYPERTENS, V31, P451, DOI 10.1080/10641960902825487
   Navaneethan SD, 2009, SURG OBES RELAT DIS, V5, P662, DOI 10.1016/j.soard.2009.01.006
   Navarro-Díaz M, 2006, J AM SOC NEPHROL, V17, pS213, DOI 10.1681/ASN.2006080917
   Ninomiya Toshiharu, 2007, J Cardiometab Syndr, V2, P104, DOI 10.1111/j.1559-4564.2007.05734.x
   Nizar JM, 2016, AM J PHYSIOL-RENAL, V310, pF812, DOI 10.1152/ajprenal.00265.2015
   ODEA K, 1977, METABOLISM, V26, P763, DOI 10.1016/0026-0495(77)90063-4
   Ogura M, 2012, GENE THER, V19, P476, DOI 10.1038/gt.2011.183
   OKAMOTO KOZO, 1963, JAPAN CIRCULATION JOUR, V27, P282
   Osmond JM, 2010, AM J PHYSIOL-HEART C, V299, pH55, DOI 10.1152/ajpheart.01111.2009
   Pan QR, 2014, NUTRIENTS, V6, P2619, DOI 10.3390/nu6072619
   Paulsen SJ, 2010, J ANAT, V217, P624, DOI 10.1111/j.1469-7580.2010.01285.x
   Perucca J, 2007, AM J PHYSIOL-REG I, V292, pR700, DOI 10.1152/ajpregu.00500.2006
   Poirier P, 2006, CIRCULATION, V113, P898, DOI 10.1161/CIRCULATIONAHA.106.171016
   Polichnowski AJ, 2015, AM J PHYSIOL-RENAL, V309, pF791, DOI 10.1152/ajprenal.00211.2015
   Prabhakar S, 2007, J AM SOC NEPHROL, V18, P2945, DOI 10.1681/ASN.2006080895
   Praga M, 2000, KIDNEY INT, V58, P2111, DOI 10.1046/j.1523-1755.2000.00384.x
   Praga M, 2002, NEPHROL DIAL TRANSPL, V17, P1157, DOI 10.1093/ndt/17.7.1157
   Rabot S, 2010, FASEB J, V24, P4948, DOI 10.1096/fj.10-164921
   Rafikova O, 2008, METABOLISM, V57, P1434, DOI 10.1016/j.metabol.2008.05.014
   Ramezani A, 2014, J AM SOC NEPHROL, V25, P657, DOI 10.1681/ASN.2013080905
   RUBEN Z, 1984, HUM PATHOL, V15, P902, DOI 10.1016/S0046-8177(84)80116-1
   Ruiz-Tovar J, 2015, OBES SURG, V25, P796, DOI 10.1007/s11695-014-1486-5
   Saliba J, 2010, SURGERY, V147, P282, DOI 10.1016/j.surg.2009.09.017
   Sandberg K, 2012, BIOL SEX DIFFER, V3, DOI 10.1186/2042-6410-3-7
   Seliger SL, 2001, CURR OPIN NEPHROL HY, V10, P219, DOI 10.1097/00041552-200103000-00010
   Neto AS, 2009, J NEPHROL, V22, P637
   Siwy J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051334
   Spradley FT, 2013, ACTA PHYSIOL, V207, P358, DOI 10.1111/apha.12025
   Spradley FT, 2013, PHYSIOL REP, V1, DOI 10.1002/phy2.137
   Srivastava T, 2006, PEDIATR NEPHROL, V21, P463, DOI 10.1007/s00467-006-0027-4
   Stemmer K, 2012, DIS MODEL MECH, V5, P627, DOI 10.1242/dmm.009407
   Stevenson FT, 2001, OBES RES, V9, P492, DOI 10.1038/oby.2001.64
   Swinburn BA, 2011, LANCET, V378, P804, DOI 10.1016/S0140-6736(11)60813-1
   Takatsu M, 2013, HYPERTENSION, V62, P957, DOI 10.1161/HYPERTENSIONAHA.113.02093
   Takaya K, 1996, NAT GENET, V14, P130, DOI 10.1038/ng1096-130
   Tofovic SP, 2000, RENAL FAILURE, V22, P387, DOI 10.1081/JDI-100100882
   Tofovic SP, 2016, J PHARMACOL EXP THER, V356, P333, DOI 10.1124/jpet.115.228841
   Turnbaugh PJ, 2008, CELL HOST MICROBE, V3, P213, DOI 10.1016/j.chom.2008.02.015
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Vallon V, 1999, J AM SOC NEPHROL, V10, P2569
   Vallon V, 2017, DIABETOLOGIA, V60, P215, DOI 10.1007/s00125-016-4157-3
   van Dijk CGM, 2016, CIRC-HEART FAIL, V9, DOI 10.1161/CIRCHEARTFAILURE.115.002760
   Vaziri ND, 2013, KIDNEY INT, V83, P308, DOI 10.1038/ki.2012.345
   Vora JP, 1996, J AM SOC NEPHROL, V7, P113
   Wahba IM, 2007, CLIN J AM SOC NEPHRO, V2, P550, DOI 10.2215/CJN.04071206
   Wang Y, 2008, KIDNEY INT, V73, P19, DOI 10.1038/sj.ki.5002586
   Wang YF, 2006, ADV CHRONIC KIDNEY D, V13, P336, DOI 10.1053/j.ackd.2006.07.016
   WESSON DE, 1985, NEPHRON, V40, P235, DOI 10.1159/000183467
   White DW, 1997, P NATL ACAD SCI USA, V94, P10657, DOI 10.1073/pnas.94.20.10657
   Yan ZC, 2013, OBESITY, V21, P538, DOI 10.1002/oby.20103
   Yanagihara H, 2016, J PHARMACOL SCI, V131, P190, DOI 10.1016/j.jphs.2016.06.003
   Yokoi N, 2013, J DIABETES RES, V2013, DOI 10.1155/2013/103731
   Youcef G, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0096452
   Zambad SP, 2011, DIABETES METAB SYNDR, V4, P5, DOI 10.2147/DMSOTT.S15323
   Zhang Di, 2007, Sheng Li Ke Xue Jin Zhan, V38, P120
   Zhang Q, 2014, BIOMARK MED, V8, P85, DOI 10.2217/bmm.13.106
   Zhao Y, 2018, EXP MOL PATHOL, V104, P12, DOI [10.1016/j.yemp.2017.11.017, 10.1016/j.yexmp.2017.11.017]
   ZUCKER TF, 1963, J NUTR, V80, P6, DOI 10.1093/jn/80.1.6
NR 154
TC 26
Z9 31
U1 0
U2 5
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD FEB
PY 2019
VL 316
IS 2
BP F316
EP F327
DI 10.1152/ajprenal.00162.2018
PG 12
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA HL3PE
UT WOS:000458627200011
PM 30539649
OA Green Published
DA 2025-06-11
ER

PT J
AU Pham, TAV
AF Pham, T. A. V.
TI The association between periodontal disease severity and metabolic
   syndrome in Vietnamese patients
SO INTERNATIONAL JOURNAL OF DENTAL HYGIENE
LA English
DT Article
DE metabolic syndrome; periodontal disease; Vietnamese
ID OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; DIABETES-MELLITUS; US
   POPULATION; RISK-FACTORS; INFECTION; JAPANESE; MARKERS; HEALTH;
   INFLAMMATION
AB Objective: To investigate the association between periodontal disease severity and metabolic syndrome (MetS) in a group of Vietnamese patients.
   Methods: A total of 412 participants (114 males, 298 females, average age 57.8 +/- 5.7years) including 206 patients with MetS and 206 participants without MetS were selected for this study. Information on sociodemographic characteristics, dental behaviours and smoking status was collected from a self-administrated questionnaire. Periodontal status including plaque index (PI), gingival index (GI) pocket depth (PD) and clinical attachment level (CAL) was recorded. Logistic regression analyses were used to evaluate the association between severity of periodontal disease and MetS with adjustments for related confounders.
   Results: The prevalence of moderate and severe periodontitis assessed by GI, PD and CAL was all significantly higher in the MetS group than in the control group and was significantly increased by a number of MetS components. Logistic regression, adjusted for confounders, showed that people with mean PI >= 2.51 or GI >= 1.01 or number of teeth with bleeding on probing of 20 teeth or PD 3.66 or CAL 3.66 showed a significant association with greater OR for MetS compared to counterparts (P < .05). The OR for MetS was 4.06 (95% CI 2.11-7.84) in severe periodontitis patients compared to non-periodontitis participants (P < .001).
   Conclusion: Much severe and extensive periodontal disease was found in MetS participants and increased with number of MetS components. Participants with higher periodontal parameters had a higher risk of MetS.
C1 [Pham, T. A. V.] Univ Med & Pharm, Fac Odontostomatol, Dept Periodontol, Ho Chi Minh City, Vietnam.
C3 Hochiminh City University of Medicine & Pharmacy
RP Pham, TAV (corresponding author), Univ Med & Pharm, Fac Odontostomatol, Dept Periodontol, Ho Chi Minh City, Vietnam.
EM pavthuy@ump.edu.vn
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alhabashneh R, 2015, J DIABETES METAB DIS, V14, DOI 10.1186/s40200-015-0192-8
   Borges I, 2007, MEDIAT INFLAMM, V2007, DOI 10.1155/2007/45794
   Bullon P, 2009, J DENT RES, V88, P503, DOI 10.1177/0022034509337479
   Bullon P, 2014, PERIODONTOL 2000, V64, P139, DOI 10.1111/j.1600-0757.2012.00455.x
   D'Aiuto F, 2008, J CLIN ENDOCR METAB, V93, P3989, DOI 10.1210/jc.2007-2522
   Eke PI, 2012, J PERIODONTOL, V83, P1449, DOI 10.1902/jop.2012.110664
   Ford ES, 2003, ATHEROSCLEROSIS, V168, P351, DOI 10.1016/S0021-9150(03)00134-5
   Fukui N, 2012, J PERIODONTOL, V83, P1363, DOI 10.1902/jop.2012.110605
   Han DH, 2012, J PERIODONTOL, V83, P612, DOI 10.1902/jop.2011.110304
   Han DH, 2010, J CLIN PERIODONTOL, V37, P609, DOI 10.1111/j.1600-051X.2010.01580.x
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Higashi Y, 2008, HYPERTENSION, V51, P446, DOI 10.1161/HYPERTENSIONAHA.107.101535
   Huy TV., 2004, J GERIATR CARDIOL, V1, P95
   International Diabetes Federation, 2007, IDF CONS DEF MET SYN
   Janket SJ, 2008, ORAL SURG ORAL MED O, V105, P173, DOI 10.1016/j.tripleo.2007.06.027
   Katz J, 2002, J PERIODONTOL, V73, P494, DOI 10.1902/jop.2002.73.5.494
   Khader Y, 2008, J PERIODONTOL, V79, P2048, DOI [10.1902/jop.2008.080022, 10.1902/jop.2008.080022 ]
   Khosravi R, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/728987
   Kikui M, 2017, J ATHEROSCLER THROMB, V24, P495, DOI 10.5551/jat.33761
   Leroy R, 2010, BMC ORAL HEALTH, V10, DOI 10.1186/1472-6831-10-8
   Li Y, 2015, J DENT RES, V94, P362, DOI 10.1177/0022034514561658
   LOE H, 1967, J PERIODONTOL, V38, P610, DOI 10.1902/jop.1967.38.6.610
   Lösche W, 2000, J CLIN PERIODONTOL, V27, P537, DOI 10.1034/j.1600-051x.2000.027008537.x
   Montebugnoli L, 2004, J CLIN PERIODONTOL, V31, P25, DOI 10.1111/j.0303-6979.2004.00432.x
   Moriyama K, 2016, J ATHEROSCLER THROMB, V23, P704, DOI 10.5551/jat.32896
   Nibali L, 2007, J CLIN PERIODONTOL, V34, P931, DOI 10.1111/j.1600-051X.2007.01133.x
   Saito T, 2004, J DENT RES, V83, P485, DOI 10.1177/154405910408300610
   Saxlin T, 2009, J CLIN PERIODONTOL, V36, P100, DOI 10.1111/j.1600-051X.2008.01350.x
   Slade GD, 2000, J DENT RES, V79, P49, DOI 10.1177/00220345000790010701
   Son LNTD, 2005, DIABETES RES CLIN PR, V67, P243, DOI 10.1016/j.diabres.2004.07.014
   Sora ND, 2013, J CLIN PERIODONTOL, V40, P599, DOI 10.1111/jcpe.12104
   Stumvoll M, 2005, LANCET, V365, P1333, DOI 10.1016/S0140-6736(05)61032-X
   Taylor BA, 2006, J DENT RES, V85, P74, DOI 10.1177/154405910608500113
   Thanakun S, 2014, J PERIODONTOL, V85, P1502, DOI 10.1902/jop.2014.140105
   Tonetti MS, 2007, NEW ENGL J MED, V356, P911, DOI 10.1056/NEJMoa063186
   Binh TQ, 2014, BMC ENDOCR DISORD, V14, DOI 10.1186/1472-6823-14-77
   Tu YK, 2013, J CLIN PERIODONTOL, V40, P994, DOI 10.1111/jcpe.12157
   Yu Zhuo-ren, 2012, Beijing Da Xue Xue Bao Yi Xue Ban, V44, P633
   Ziccardi P, 2002, CIRCULATION, V105, P804, DOI 10.1161/hc0702.104279
   Zuk A, 2017, J CLIN PERIODONTOL, V44, P132, DOI 10.1111/jcpe.12684
NR 41
TC 19
Z9 21
U1 1
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1601-5029
EI 1601-5037
J9 INT J DENT HYG
JI Int. J. Dent. Hyg.
PD NOV
PY 2018
VL 16
IS 4
BP 484
EP 491
DI 10.1111/idh.12350
PG 8
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA GW9GP
UT WOS:000447291600008
PM 29900658
DA 2025-06-11
ER

PT J
AU Aksu, AEK
   Saraçoglu, ZN
   Metintas, S
   Sabuncu, I
   Çetin, Y
AF Aksu, Ayse Esra Koku
   Saracoglu, Zeynep Nurhan
   Metintas, Selma
   Sabuncu, Ilham
   Cetin, Yildiz
TI Age and gender differences in Framingham risk score and metabolic
   syndrome in psoriasis patients: A cross-sectional study in the Turkish
   population
SO ANATOLIAN JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Framingham risk score; metabolic syndrome; psoriasis
ID CORONARY-HEART-DISEASE; OBESE-PATIENTS; PREVALENCE; DIAGNOSIS; MODERATE;
   THERAPY; ASSOCIATION; PREDICTION; STRESS
AB Objective: Psoriasis is associated with an increased frequency of cardiovascular risk factors. Metabolic syndrome ( MS) and the Framingham risk score (FRS) are two different algorithms for evaluating cardiovascular risk. They include different features: waist circumference measurement is included in the MS criteria, whereas smoking, age, and gender are questioned in FRS. This study aimed to evaluate the frequency of MS and FRS in psoriasis patients compared with a control group and investigate the differences between MS and FRS.
   Methods: This was a cross-sectional study involving 300 psoriasis patients and 177 controls. MS, FRS, and disease severity were evaluated.
   Results: The frequency of MS was higher in females with psoriasis than in those in the control group (p=0.019). Females in the psoriasis group were more obese than those in the control group (p=0.036). FRS significantly differed between the patients and controls of age >60 years (p=0.006). The risk of hypertension in current and past smokers was higher in the psoriasis patients (OR=2.07 and 2.32-2.48, respectively) than in the control group. There was no statistically significant relationship among MS, FRS, and psoriasis severity (p>0.05).
   Conclusion: The results of this study support the evaluation of cardiovascular risk assessment in female psoriasis patients with MS and in male and elderly psoriasis patients with FRS.
C1 [Aksu, Ayse Esra Koku; Saracoglu, Zeynep Nurhan; Sabuncu, Ilham] Eskisehir Osmangazi Univ, Dept Dermatol, Eskisehir, Turkey.
   [Metintas, Selma] Eskisehir Osmangazi Univ, Dept Publ Hlth, Eskisehir, Turkey.
   [Cetin, Yildiz] Kent Hosp, Dept Dermatol, Kutahya, Turkey.
C3 Eskisehir Osmangazi University; Eskisehir Osmangazi University; Kent
   Hospital
RP Aksu, AEK (corresponding author), Istanbul Egitim & Arastirma Hastanesi, Cildiye Bolumu, Kasap Ilyas Mah,Org Abdurrahman Nafiz Gurman Cd, TR-34098 Istanbul, Turkey.
EM esraaksu@gmail.com
RI Koku Aksu, Ayse/ADK-4325-2022
OI Metintas, Selma/0000-0002-5002-5041; Koku Aksu, Ayse
   Esra/0000-0002-3457-1958
CR Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Alsufyani MA, 2010, DERMATOL THER, V23, P137, DOI 10.1111/j.1529-8019.2010.01307.x
   Armstrong AW, 2011, BRIT J DERMATOL, V165, P1162, DOI 10.1111/j.1365-2133.2011.10526.x
   Bergersen BM, 2004, EUR J CLIN MICROBIOL, V23, P625, DOI 10.1007/s10096-004-1177-6
   Boehncke S, 2007, BRIT J DERMATOL, V157, P1249, DOI 10.1111/j.1365-2133.2007.08190.x
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   Choi WJ, 2010, ANN DERMATOL, V22, P300, DOI 10.5021/ad.2010.22.3.300
   Cohen AD, 2008, DERMATOLOGY, V216, P152, DOI 10.1159/000111512
   Crosta ML, 2014, GIORN ITAL DERMAT V, V149, P355
   Netto MVD, 2012, TRANSPL P, V44, P2337, DOI 10.1016/j.transproceed.2012.07.054
   Del Giglio M, 2012, DERMATOLOGY, V224, P31, DOI 10.1159/000335566
   Del Valle Megan C, 2006, Prim Care Companion J Clin Psychiatry, V8, P329
   Eichler K, 2007, AM HEART J, V153, P722, DOI 10.1016/j.ahj.2007.02.027
   Epel E, 2001, PSYCHONEUROENDOCRINO, V26, P37, DOI 10.1016/S0306-4530(00)00035-4
   Erem C, 2004, OBES RES, V12, P1117, DOI 10.1038/oby.2004.140
   Fernández-Torres R, 2013, J EUR ACAD DERMATOL, V27, P1566, DOI 10.1111/j.1468-3083.2012.04618.x
   FREDRIKSSON T, 1978, DERMATOLOGICA, V157, P238, DOI 10.1159/000250839
   Gelfand JM, 2006, JAMA-J AM MED ASSOC, V296, P1735, DOI 10.1001/jama.296.14.1735
   Gisondi P, 2008, AM J CLIN NUTR, V88, P1242, DOI 10.3945/ajcn.2008.26427
   Gisondi P, 2010, AM J CARDIOL, V106, P1754, DOI 10.1016/j.amjcard.2010.08.016
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Gyldenlove M, 2014, INT J DERMATOL, V53, P1086, DOI 10.1111/ijd.12196
   Jensen P, 2013, INT J DERMATOL, V52, P681, DOI 10.1111/j.1365-4632.2011.05408.x
   Kim CR, 2013, ANN DERMATOL, V25, P440, DOI 10.5021/ad.2013.25.4.440
   Kimball AB, 2012, J AM ACAD DERMATOL, V67, P76, DOI 10.1016/j.jaad.2011.06.035
   Kimball AB, 2010, AM J MED, V123, P350, DOI 10.1016/j.amjmed.2009.08.022
   Kumar S, 2013, J EUR ACAD DERMATOL, V27, P1293, DOI 10.1111/jdv.12001
   Langan SM, 2012, J INVEST DERMATOL, V132, P556, DOI 10.1038/jid.2011.365
   Mallbris L, 2006, J AM ACAD DERMATOL, V54, P614, DOI 10.1016/j.jaad.2005.11.1079
   Myasoedova E, 2013, SCI CAIRO, V2013
   Neimann AL, 2006, J AM ACAD DERMATOL, V55, P829, DOI 10.1016/j.jaad.2006.08.040
   Baeta IGR, 2014, AN BRAS DERMATOL, V89, P735, DOI 10.1590/abd1806-4841.20142874
   Rosa DJF, 2012, J EUR ACAD DERMATOL, V26, P348, DOI 10.1111/j.1468-3083.2011.04076.x
   Sales R, 2014, ACTA DERMATOVENER CR, V22, P169
   Sommer DM, 2006, ARCH DERMATOL RES, V298, P321, DOI 10.1007/s00403-006-0703-z
   Sopori M, 2002, NAT REV IMMUNOL, V2, P372, DOI 10.1038/nri803
   Stern RS, 2011, J INVEST DERMATOL, V131, P1159, DOI 10.1038/jid.2010.399
   Takahashi H, 2010, J DERMATOL SCI, V57, P143, DOI 10.1016/j.jdermsci.2009.11.002
   Teramoto T, 2007, J ATHEROSCLER THROMB, V14, P155, DOI 10.5551/jat.E537
   Ünal B, 2013, ANATOL J CARDIOL, V13, P9, DOI 10.5152/akd.2013.002
   Wakkee M, 2010, J INVEST DERMATOL, V130, P962, DOI 10.1038/jid.2009.321
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Wilson PWF, 1998, CIRCULATION, V97, P1837, DOI 10.1161/01.CIR.97.18.1837
   Winkler G, 2003, EUR J ENDOCRINOL, V149, P129, DOI 10.1530/eje.0.1490129
   Wu Y, 2008, J DRUGS DERMATOL, V7, P373
NR 45
TC 11
Z9 12
U1 0
U2 3
PU AVES
PI SISLI
PA BUYUKDERE CAD 105-9, MECIDIYEKOY, SISLI, ISTANBUL 34394, TURKEY
SN 2149-2263
EI 2149-2271
J9 ANATOL J CARDIOL
JI Anat. J. Cardiol.
PD JAN
PY 2017
VL 17
IS 1
BP 66
EP 72
DI 10.14744/AnatolJCardiol.2016.6679
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EK4JJ
UT WOS:000393892600014
PM 27271475
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Fuller, S
   Stephens, JM
AF Fuller, Scott
   Stephens, Jacqueline M.
TI Diosgenin, 4-Hydroxyisoleucine, and Fiber from Fenugreek: Mechanisms of
   Actions and Potential Effects on Metabolic Syndrome
SO ADVANCES IN NUTRITION
LA English
DT Review
DE fat cells; insulin action; botanicals; fenugreek; diosgenin;
   4-hydroxyisoleucine
ID TRIGONELLA-FOENUM-GRAECUM; FATTY LIVER-DISEASE; RENAL-FAILURE RATS;
   UNUSUAL AMINO-ACID; INSULIN-RESISTANCE; DIETARY FIBER; DIABETIC-RATS;
   ECTOPIC FAT; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE
AB Metabolic syndrome and its complications continue to rise in prevalence and show no signs of abating in the immediate future. Therefore, the search for effective treatments is a high priority in biomedical research. Products derived from botanicals have a time-honored history of use in the treatment of metabolic diseases including type 2 diabetes. Trigonella foenum-graecum, commonly known as fenugreek, is an annual herbaceous plant that has been a staple of traditional herbal medicine in many cultures. Although fenugreek has been studied in both clinical and basic research settings, questions remain about its efficacy and biologic mechanisms of action. Diosgenin, 4-hydroxyisoleucine, and the fiber component of the plant are the most intensively studied bioactive constituents present in fenugreek. These compounds have been demonstrated to exert beneficial effects on several physiologic markers including glucose tolerance, inflammation, insulin action, liver function, blood lipids, and cardiovascular health. Although insights into the molecular mechanisms underlying the favorable effects of fenugreek have been gained, we still do not have definitive evidence establishing its role as a therapeutic agent in metabolic disease. This review aims to summarize the currently available evidence on the physiologic effects of the 3 best-characterized bioactive compounds of fenugreek, with particular emphasis on biologic mechanisms of action relevant in the context of metabolic syndrome.
C1 [Fuller, Scott; Stephens, Jacqueline M.] Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
   [Stephens, Jacqueline M.] Louisiana State Univ, Dept Biol Sci, Baton Rouge, LA 70803 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center; Louisiana State University
   System; Louisiana State University
RP Stephens, JM (corresponding author), Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
RI Fuller, Scott/GWM-5641-2022; Stephens, Jacqueline/R-5217-2018
FU postdoctoral training fellowship [T32 AT004094]
FX Supported by a postdoctoral training fellowship T32 AT004094 (to SF)
   awarded to Pennington Biomedical Research Center.
CR Ahmadian M, 2013, NAT MED, V19, P557, DOI 10.1038/nm.3159
   Ahmed LA, 2014, EUR J PHARMACOL, V740, P379, DOI 10.1016/j.ejphar.2014.07.026
   [Anonymous], 2014, BIOMED RES INT, DOI DOI 10.1155/2014/606021
   [Anonymous], 2011, National diabetes fact sheet: national estimates and general information on diabetes and prediabetes in the United States, 2011
   Badalzadeh R, 2014, J PHYSIOL SCI, V64, P393, DOI 10.1007/s12576-014-0333-8
   Balabanova Y, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0073052
   Blüher M, 2014, MOL METAB, V3, P230, DOI 10.1016/j.molmet.2014.01.005
   Boban PT, 2006, BRIT J NUTR, V96, P1021, DOI 10.1017/BJN20061944
   Broca C, 2004, AM J PHYSIOL-ENDOC M, V287, pE463, DOI 10.1152/ajpendo.00163.2003
   Broca C, 1999, AM J PHYSIOL-ENDOC M, V277, pE617, DOI 10.1152/ajpendo.1999.277.4.E617
   Broca C, 2000, EUR J PHARMACOL, V390, P339, DOI 10.1016/S0014-2999(00)00030-3
   Buchholz U, 2011, NEW ENGL J MED, V365, P1763, DOI 10.1056/NEJMoa1106482
   Byrne CD, 2014, ARTERIOSCL THROM VAS, V34, P1155, DOI 10.1161/ATVBAHA.114.303034
   Cariou B, 2012, TRENDS ENDOCRIN MET, V23, P205, DOI 10.1016/j.tem.2012.03.001
   Cohen PA, 2014, NEW ENGL J MED, V370, P1277, DOI 10.1056/NEJMp1315559
   Cohen PA, 2009, NEW ENGL J MED, V361, P1523, DOI 10.1056/NEJMp0904768
   Cox AJ., 2014, LANCET DIABETES ENDO
   Das S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046641
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   Doyle JP, 2009, FOOD HYDROCOLLOID, V23, P1501, DOI 10.1016/j.foodhyd.2008.09.007
   Eastwood M, 2005, ANNU REV NUTR, V25, P1, DOI 10.1146/annurev.nutr.25.121304.131658
   Ebrahimi H, 2014, J PHYSIOL BIOCHEM, V70, P425, DOI 10.1007/s13105-014-0320-9
   Edwards PA, 2002, J LIPID RES, V43, P2
   Feng D, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-40
   FOWDEN L, 1973, PHYTOCHEMISTRY, V12, P1707, DOI 10.1016/0031-9422(73)80391-7
   Guariguata L, 2011, DIABETES RES CLIN PR, V94, P322, DOI 10.1016/j.diabres.2011.10.040
   Haeri MR, 2009, PHYTOTHER RES, V23, P61, DOI 10.1002/ptr.2557
   Haeri MR, 2012, PHYTOMEDICINE, V19, P571, DOI 10.1016/j.phymed.2012.01.004
   Hamden K, 2010, BIOTECHNOL BIOPROC E, V15, P407, DOI 10.1007/s12257-009-3037-9
   Hannan JMA, 2007, BRIT J NUTR, V97, P514, DOI 10.1017/S0007114507657869
   Hannan JMA, 2003, J ETHNOPHARMACOL, V88, P73, DOI 10.1016/S0378-8741(03)00190-9
   Heo SJ, 2009, EUR J PHARMACOL, V615, P252, DOI 10.1016/j.ejphar.2009.05.017
   Hirai S, 2010, MOL NUTR FOOD RES, V54, P797, DOI 10.1002/mnfr.200900208
   Horton JD, 2002, J CLIN INVEST, V109, P1125, DOI 10.1172/JCI200215593
   Huang YY, 2013, LIPIDS HEALTH DIS, V12, DOI 10.1186/1476-511X-12-171
   Jaiswal N, 2012, EUR J NUTR, V51, P893, DOI 10.1007/s00394-012-0374-9
   JENNINGS AM, 1989, DIABETES CARE, V12, P203, DOI 10.2337/diacare.12.3.203
   Kalailingam P, 2014, PHYTOMEDICINE, V21, P1154, DOI 10.1016/j.phymed.2014.04.005
   Ku S, 2009, FOOD SCI BIOTECHNOL, V18, P749
   Lim S, 2014, ARTERIOSCL THROM VAS, V34, P1820, DOI 10.1161/ATVBAHA.114.303035
   Lim S, 2013, INT J CARDIOL, V169, P166, DOI 10.1016/j.ijcard.2013.08.077
   Lima CM, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-195
   Liu K, 2012, ATHEROSCLEROSIS, V223, P350, DOI 10.1016/j.atherosclerosis.2012.06.012
   Manivannan J, 2014, BIOCHIMIE, V102, P183, DOI 10.1016/j.biochi.2014.03.011
   Manivannan J, 2013, MOL CELL BIOCHEM, V384, P113, DOI 10.1007/s11010-013-1788-2
   Manivannan J, 2013, MOL CELL BIOCHEM, V378, P9, DOI 10.1007/s11010-013-1588-8
   Maurya CK, 2014, MOL CELL ENDOCRINOL, V395, P51, DOI 10.1016/j.mce.2014.07.018
   Morelli M, 2013, THROMB HAEMOSTASIS, V110, P651, DOI 10.1160/TH13-04-0285
   Moreno-Indias I, 2014, FRONT MICROBIOL, V5, DOI 10.3389/fmicb.2014.00190
   Mraz M, 2014, J ENDOCRINOL, V222, pR113, DOI 10.1530/JOE-14-0283
   Narender T, 2006, BIOORG MED CHEM LETT, V16, P293, DOI 10.1016/j.bmcl.2005.10.003
   Neelakantan N, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-7
   Oh SH, 2008, CLIN CHEM LAB MED, V46, P1245, DOI 10.1515/CCLM.2008.252
   Overby NC, 2013, FOOD NUTR RES, P57
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Pari L, 2012, EUR J PHARMACOL, V691, P143, DOI 10.1016/j.ejphar.2012.06.038
   Qin Y, 2009, J ETHNOPHARMACOL, V126, P543, DOI 10.1016/j.jep.2009.08.047
   Ramulu P, 2011, J MED PLANTS RES, V5, P4804
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Rizvi SI, 2013, J DIABETES RES, V2013, DOI 10.1155/2013/712092
   Roberts KT, 2011, J MED FOOD, V14, P1485, DOI 10.1089/jmf.2011.0002
   Rosen ED, 2014, CELL, V156, P20, DOI 10.1016/j.cell.2013.12.012
   Salimeh A, 2013, J PHYSIOL BIOCHEM, V69, P255, DOI 10.1007/s13105-012-0208-5
   Sangeetha MK, 2013, CHEM-BIOL INTERACT, V206, P403, DOI 10.1016/j.cbi.2013.08.014
   Saravanan G, 2014, CAN J DIABETES, V38, P409, DOI 10.1016/j.jcjd.2014.02.004
   SAUVAIRE Y, 1984, PHYTOCHEMISTRY, V23, P479, DOI 10.1016/S0031-9422(00)80363-5
   Sauvaire Y, 1998, DIABETES, V47, P206, DOI 10.2337/diabetes.47.2.206
   Saxena A, 2004, J ALTERN COMPLEM MED, V10, P369, DOI 10.1089/107555304323062365
   Shimabukuro M, 2013, J MED INVESTIG, V60, P1, DOI 10.2152/jmi.60.1
   Shoaie S, 2014, FRONT GENET, V5, DOI 10.3389/fgene.2014.00086
   Silva FM, 2013, NUTR REV, V71, P790, DOI 10.1111/nure.12076
   Singh AB, 2010, NAT PROD RES, V24, P258, DOI 10.1080/14786410902836693
   Son IS, 2007, BIOSCI BIOTECH BIOCH, V71, P3063, DOI 10.1271/bbb.70472
   Spiegelman B M, 1997, Eur J Med Res, V2, P457
   Srichamroen A, 2008, J CLIN BIOCHEM NUTR, V43, P167, DOI 10.3164/jcbn.2008060
   Srichamroen A, 2009, NUTR RES, V29, P49, DOI 10.1016/j.nutres.2008.11.002
   Tang WQ, 2011, BBA-MOL CELL BIOL L, V1811, P549, DOI 10.1016/j.bbalip.2011.05.013
   Temel RE, 2009, J LIPID RES, V50, P915, DOI 10.1194/jlr.M800631-JLR200
   Tharaheswari M, 2014, MOL CELL BIOCHEM, V396, P161, DOI 10.1007/s11010-014-2152-x
   Turer AT, 2012, DIABETOLOGIA, V55, P2319, DOI 10.1007/s00125-012-2598-x
   Turer AT, 2012, CIRC RES, V111, P1565, DOI [10.1161/CIRCRESAHA.111.262493, 10.1161/circresaha.111.262493]
   Uemura T, 2011, J NUTR, V141, P17, DOI 10.3945/jn.110.125591
   Uemura T, 2010, MOL NUTR FOOD RES, V54, P1596, DOI 10.1002/mnfr.200900609
   Venkatesan N, 2007, MOL CELL BIOCHEM, V294, P145, DOI 10.1007/s11010-006-9254-z
   Walsh CJ, 2014, FEBS LETT, V588, P4120, DOI 10.1016/j.febslet.2014.03.035
   Wang E, 2008, DIABETES EDUCATOR, V34, P645, DOI 10.1177/0145721708320559
   Wang HY, 2005, J CELL SCI, V118, P3905, DOI 10.1242/jcs.02513
   Wang ZJ, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/343594
   Yadav UCS, 2014, PHARM BIOL, V52, P243, DOI 10.3109/13880209.2013.826247
   Yamada T, 1997, AM J PHYSIOL-GASTR L, V273, pG355, DOI 10.1152/ajpgi.1997.273.2.G355
   Yilmaz Y, 2014, CLIN LIVER DIS, V18, P19, DOI 10.1016/j.cld.2013.09.018
   Yu Hai, 2013, Zhongguo Zhong Xi Yi Jie He Za Zhi, V33, P1394
NR 93
TC 90
Z9 99
U1 1
U2 39
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2161-8313
EI 2156-5376
J9 ADV NUTR
JI Adv. Nutr.
PD MAR
PY 2015
VL 6
IS 2
BP 189
EP 197
DI 10.3945/an.114.007807
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CE0GU
UT WOS:000351483300005
PM 25770257
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Barghchi, H
   Milkarizi, N
   Belyani, S
   Ostad, AN
   Askari, VR
   Rajabzadeh, F
   Goshayeshi, L
   Kheyrabadi, SYG
   Razavidarmian, M
   Dehnavi, Z
   Sobhani, SR
   Nematy, M
AF Barghchi, Hanieh
   Milkarizi, Narges
   Belyani, Saba
   Norouzian Ostad, Andisheh
   Askari, Vahid Reza
   Rajabzadeh, Farnood
   Goshayeshi, Ladan
   Ghelichi Kheyrabadi, Seyede Yegane
   Razavidarmian, Maryam
   Dehnavi, Zahra
   Sobhani, Seyyed Reza
   Nematy, Mohsen
TI Pomegranate (Punica granatum L.) peel extract ameliorates
   metabolic syndrome risk factors in patients with non-alcoholic fatty
   liver disease: a randomized double-blind clinical trial
SO NUTRITION JOURNAL
LA English
DT Article
DE Pomegranate Peel; Metabolic syndrome; Fatty liver; Dyslipidemia;
   Hypertension
ID OXIDATIVE STRESS; OBESE WOMEN; SUPPLEMENTATION; DIET; INFLAMMATION;
   POLYPHENOLS; ACCUMULATION; CELLS; NAFLD
AB IntroductionNon-alcoholic fatty liver disease (NAFLD) is a metabolic syndrome (MS)-related liver disorder that has an increasing prevalence. Thus, the aim of our study is to evaluate the effects of pomegranate peel extract (PP) supplementation on hepatic status and metabolic syndrome risk factors.MethodsIn phase one, the hydro-alcoholic extraction of the peel of 750 kg of pomegranate (Punica granatum L.) was performed by the soaking method. Then, in phase two, NAFLD patients received 1500 mg of placebo (n = 37) or pomegranate peel capsules (n = 39) with a 500-kcal deficit diet for 8 weeks. Gastrointestinal intolerance, dietary intake, lipid and glycemic profiles, systolic and diastolic blood pressure, body composition, insulin resistance indexes, and elastography-evaluated NAFLD changes were followed.ResultsThe mean age of participants was 43.1 & PLUSMN; 8.6 years (51.3% female). Following the intervention, the mean body weight (mean changes: -5.10 & PLUSMN; 2.30 kg), waist circumference (-7.57 & PLUSMN; 2.97 cm), body mass index (-1.82 & PLUSMN; 0.85 kg/m(2)), body fat index (-1.49 & PLUSMN; 0.86), and trunk fat (- 3.93 & PLUSMN; 3.07%), systolic (-0.63 & PLUSMN; 0.29 cmHg) and diastolic (-0.39 & PLUSMN; 0.19 cmHg) blood pressure, total cholesterol (-10.51 & PLUSMN; 0.77 mg/dl), triglyceride (-16.02 & PLUSMN; 1.7 mg/dl), low-density lipoprotein cholesterol (-9.33 & PLUSMN; 6.66 mg/dl; all P < 0.001), fat free mass (- 0.92 & PLUSMN; 0.90 kg; P < 0.003), and fasting blood sugar (-5.28 & PLUSMN; 1.36 mg/dl; P = 0.02) decreased significantly in PP in contrast to the placebo group in the raw model and when adjusted for confounders. Also, high-density lipoprotein cholesterol (5.10 & PLUSMN; 0.36 mg/dl), liver steatosis and stiffness (- 0.30 & PLUSMN; 0.17 and - 0.72 & PLUSMN; 0.35 kPa, respectively, all P < 0.001) improved in the PP group. However, fasting insulin (P = 0.81) and homeostatic model assessment for insulin resistance (HOMA-IR) (P = 0.93) were not significantly different when comparing two groups during the study in the raw and even adjusted models.ConclusionIn conclusion, 1500 mg pomegranate peel extract along with a weight-loss diet improved metabolic syndrome risk factors and reduced hepatic steatosis in patients with NAFLD after 8 weeks.
C1 [Barghchi, Hanieh; Norouzian Ostad, Andisheh; Ghelichi Kheyrabadi, Seyede Yegane; Dehnavi, Zahra; Sobhani, Seyyed Reza; Nematy, Mohsen] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Iran.
   [Barghchi, Hanieh; Dehnavi, Zahra] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Iran.
   [Milkarizi, Narges; Nematy, Mohsen] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Sch Med, Dept Nutr, Mashhad, Iran.
   [Belyani, Saba] North Khorasan Univ Med Sci, Student Res Comm, Bojnourd, Iran.
   [Askari, Vahid Reza] Mashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Iran.
   [Askari, Vahid Reza] Mashhad Univ Med Sci, Neurogenic Inflammat Res Ctr, Mashhad, Iran.
   [Rajabzadeh, Farnood] Islamic Azad Univ, Dept Radiol, Mashhad Med Sci Branch, Mashhad, Iran.
   [Goshayeshi, Ladan] Mashhad Univ Med Sci, Fac Med, Dept Gastroenterol & Hepatol, Mashhad, Iran.
   [Goshayeshi, Ladan] Mashhad Univ Med Sci, Gastroenterol & Hepatol Res Ctr, Mashhad, Iran.
   [Razavidarmian, Maryam] Varastegan Inst Med Sci, Dept Nutr Sci, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; North Khorasan
   University of Medical Sciences; Mashhad University of Medical Sciences;
   Mashhad University of Medical Sciences; Islamic Azad University; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences;
   Mashhad University of Medical Sciences
RP Nematy, M (corresponding author), Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Iran.; Nematy, M (corresponding author), Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Sch Med, Dept Nutr, Mashhad, Iran.
EM nematym@mums.ac.ir
RI dehnavi, zahra/AAO-4256-2021; goshayeshi, ladan/AAQ-2715-2020; Sobhani,
   Seyyed/AAZ-8324-2020; rajabzadeh, farnood/ABA-8747-2021; Askari, Vahid
   Reza/ABB-8991-2020
OI Belyani, Saba/0000-0002-7044-1819
CR Abdel-Rahim EA, 2013, GRASAS ACEITES, V64, P50, DOI 10.3989/gya.095412
   Abozid M.M., 2013, J. Biol. Chem. Environ. Sci, V8, P83
   Akhtar S, 2015, FOOD CHEM, V174, P417, DOI 10.1016/j.foodchem.2014.11.035
   Al-Shaaibi Siham N K, 2016, Prev Nutr Food Sci, V21, P14, DOI [10.3746/pnf.2016.21.1.14, 10.3746/pnf.2016.21.1.20]
   Ali MY, 2023, J AGR FOOD CHEM, V71, P11476, DOI 10.1021/acs.jafc.3c02115
   Altunkaya A, 2014, IRISH J AGR FOOD RES, V53, P121
   Amini H, 2020, HELIYON, V6, DOI 10.1016/j.heliyon.2020.e05411
   Arun KB, 2017, J FOOD PROCESS PRES, V41, DOI 10.1111/jfpp.13108
   Ayad BM, PROTECTIVE EFFECT PO
   Barghchi H, 2023, J NUTR FASTING HLTH, V11
   Becerra-Tomas N, 2020, CRIT REV FOOD SCI, V60, P1207, DOI 10.1080/10408398.2019.1565281
   Campanella A, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061674
   Craig C., 2017, Journal of American College Health, V65, P492
   Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI23621
   dos Santos RL, 2016, J TOXICOL ENV HEAL A, V79, P998, DOI 10.1080/15287394.2016.1213690
   Du L, 2019, FOOD NUTR RES, V63, DOI 10.29219/fnr.v63.3392
   Ekambaram SP, 2016, PHYTOTHER RES, V30, P1035, DOI 10.1002/ptr.5616
   Elsaid FG, 2018, The Egyptian Journal of Hospital Medicine, V71, P3079
   Estes C, 2018, J HEPATOL, V69, P896, DOI 10.1016/j.jhep.2018.05.036
   Faddladdeen KAJ, 2021, FOLIA MORPHOL, V80, P149, DOI 10.5603/FM.a2020.0034
   Faddladdeen Khadija A, 2019, J Microsc Ultrastruct, V7, P165, DOI 10.4103/JMAU.JMAU_6_19
   Faghihzadeh F, 2014, NUTR RES, V34, P837, DOI 10.1016/j.nutres.2014.09.005
   Faria A, 2011, CRIT REV FOOD SCI, V51, P626, DOI 10.1080/10408391003748100
   Fogacci F, 2022, APPL SCI-BASEL, V12, DOI 10.3390/app12199673
   Friedman SL, 2018, NAT MED, V24, P908, DOI 10.1038/s41591-018-0104-9
   Furman D, 2019, NAT MED, V25, P1822, DOI 10.1038/s41591-019-0675-0
   Goodarzi R, 2021, PHYTOTHER RES, V35, P5871, DOI 10.1002/ptr.7249
   Grabez M, 2020, J FUNCT FOODS, V64, DOI 10.1016/j.jff.2019.103692
   Haghighian MK, 2021, ADV INTEGR MED, V8, P107, DOI 10.1016/j.aimed.2020.05.001
   Haghighian MK, 2016, EUR J INTEGR MED, V8, P676, DOI 10.1016/j.eujim.2016.06.010
   Hallsworth K, 2019, JHEP REP, V1, P468, DOI 10.1016/j.jhepr.2019.10.008
   Harscoat-Schiavo C, 2021, EXTRACTION PHENOLICS
   Hazavehei SMM., 2008, IRAN J MED ED, V8, P121
   Heber D., 2012, POMEGRANATE ELLAGITA
   Jafari T, 2020, J FUNCT FOODS, V72, DOI 10.1016/j.jff.2020.104069
   Jafarirad S, 2023, DIABETES METAB SYND, V17, DOI 10.1016/j.dsx.2022.102693
   Johnson AR, 2012, IMMUNOL REV, V249, P218, DOI 10.1111/j.1600-065X.2012.01151.x
   Lamiaa ML, 2019, INT J PHARM RES ALLI, V8, P119
   Les F, 2018, J ETHNOPHARMACOL, V220, P67, DOI 10.1016/j.jep.2018.03.029
   Liu HH, 2021, MOL NUTR FOOD RES, V65, DOI 10.1002/mnfr.202001031
   Lv O, 2016, FOOD FUNCT, V7, P4976, DOI [10.1039/C6FO01261B, 10.1039/c6fo01261b]
   Marjot T, 2020, ENDOCR REV, V41, P66, DOI 10.1210/endrev/bnz009
   Mazaheri M., 2012, Govaresh, V17, P18
   Middha SK, 2014, EXCLI J, V13, P223
   Mirmiran P, 2017, IRAN J PUBLIC HEALTH, V46, P1007
   Mohamed MS, 2022, BIOINTERFACE RES APP, V12, P4888, DOI 10.33263/BRIAC124.48884899
   Nair Anroop B, 2016, J Basic Clin Pharm, V7, P27, DOI 10.4103/0976-0105.177703
   Navekar R, 2017, J AM COLL NUTR, V36, P261, DOI 10.1080/07315724.2016.1267597
   Nazeem MM, 2018, EFFECT POMEGRANATE P
   Neyrinck AM, 2013, BRIT J NUTR, V109, P802, DOI 10.1017/S0007114512002206
   Oddy WH, 2013, AM J GASTROENTEROL, V108, P778, DOI 10.1038/ajg.2013.95
   Omar Ulfat., 2016, ujph, V4, P268, DOI DOI 10.13189/UJPH.2016.040507
   Papadaki A, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113342
   Perumpail BJ, 2017, WORLD J GASTROENTERO, V23, P8263, DOI 10.3748/wjg.v23.i47.8263
   Pfohl M, 2021, INT J FOOD SCI NUTR, V72, P499, DOI 10.1080/09637486.2020.1849041
   Raheema RH, 2016, J ANIMAL HLTH PRODUC, V4, P42, DOI [10.14737/journal.jahp/2016/4.2.42.49, DOI 10.14737/JOURNAL.JAHP/2016/4.2.42.49]
   Rahmani S, 2016, PHYTOTHER RES, V30, P1540, DOI 10.1002/ptr.5659
   Rahnama Z., 2017, J APPL HLTH STUD SPO, V4, P1
   Raymond J.L., 2020, Krause and Mahan's Food and the Nutrition Care Process E-Book
   Romero-Gómez M, 2017, J HEPATOL, V67, P829, DOI 10.1016/j.jhep.2017.05.016
   Sadeghipour A, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/432650
   Sakata R, 2013, INT J MOL MED, V32, P989, DOI 10.3892/ijmm.2013.1503
   Salwe Kartik J, 2015, J Nat Sci Biol Med, V6, P56, DOI 10.4103/0976-9668.149085
   Sangouni AA, 2022, BRIT J NUTR, V128, P1231, DOI 10.1017/S0007114521002270
   Sheka AC, 2020, JAMA-J AM MED ASSOC, V323, P1175, DOI 10.1001/jama.2020.2298
   Soleimani D, 2021, PHYTOTHER RES, V35, P1669, DOI 10.1002/ptr.6937
   Soliman N. A., 2022, EFFECT POMEGRANATE M
   Song HZ, 2022, EUR J NUTR, V61, P1837, DOI 10.1007/s00394-021-02771-1
   Song Q, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10030524
   Sumner Anne E, 2010, CVD Prev Control, V5, P75
   Taha O., 2016, INT J PHARM PHARM SC, V8, P156
   Tao LC, 2022, CARDIOVASC DIABETOL, V21, DOI 10.1186/s12933-022-01511-x
   ter Horst KW, 2017, NUTRIENTS, V9, DOI 10.3390/nu9090981
   Tiniakos DG, 2010, ANNU REV PATHOL-MECH, V5, P145, DOI 10.1146/annurev-pathol-121808-102132
   Toklu HZ, 2007, J PHARM PHARMACOL, V59, P1287, DOI 10.1211/jpp.59.9.0014
   Venkataramanamma D, 2016, J FOOD SCI TECH MYS, V53, P2497, DOI 10.1007/s13197-016-2222-z
   Webb M, 2009, AM J ROENTGENOL, V192, P909, DOI 10.2214/AJR.07.4016
   Wei XL, 2015, BMC COMPLEM ALTERN M, V15, DOI 10.1186/s12906-015-0916-9
   Wei XL, 2020, J FUNCT FOODS, V65, DOI 10.1016/j.jff.2019.103712
   Xiao YX, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11020252
   Xu YF, 2015, J FOOD PROTECT, V78, P128, DOI 10.4315/0362-028X.JFP-14-174
   Yari Z, 2016, INT J FOOD SCI NUTR, V67, P461, DOI 10.3109/09637486.2016.1161011
   Zhao RQ, 2019, FOOD FUNCT, V10, P8273, DOI [10.1039/c9fo02077b, 10.1039/C9FO02077B]
   Zhou S, 2021, FOOD FUNCT, V12, P4654, DOI [10.1039/D0FO03044A, 10.1039/d0fo03044a]
NR 84
TC 18
Z9 18
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2891
J9 NUTR J
JI Nutr. J.
PD AUG 22
PY 2023
VL 22
IS 1
AR 40
DI 10.1186/s12937-023-00869-2
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA P6ZS3
UT WOS:001052142900001
PM 37605174
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU El-Mehi, AE
   Faried, MA
AF El-Mehi, A. E.
   Faried, M. A.
TI Effect of high-fructose diet-induced metabolic syndrome on the
   pituitary-gonadal axis from adolescence through adulthood in male albino
   rats and the possible protective role of ginger extract. A biochemical,
   histological and immunohistochemical study
SO FOLIA MORPHOLOGICA
LA English
DT Article
DE high fructose; metabolic syndrome; ginger; pituitary; testis; oxidative
   stress; histopathology; immunohistochemistry
ID INDUCED REPRODUCTIVE TOXICITY; ZINGIBER-OFFICINALE; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; CELL FUNCTION; DNA-DAMAGE; ANTIOXIDANT; AUTOPHAGY; MEN;
   SPERMATOGENESIS
AB Background: This work was designed to clarify, for the first time up to our knowledge, the effects of high-fructose diet (HFrD)-induced metabolic syndrome (MetS) on the pituitary-gonadal axis of adolescent male rats continuing through adulthood period and to evaluate the possible role of ginger extract in ameliorating these effects.
   Materials and methods: Forty 4-week-old male albino rats, treated for 8 weeks, were randomly divided into four equal groups; control (fed standard diet), ginger extract-treated (500 mg/kg once daily orally by gavage), HFrD-induced MetS (fed a diet containing 60% fructose), HFrD and ginger groups. The assessment methods included biochemical, histological and immunohistochemical studies.
   Results: High-fructose diet-fed rats exhibited a picture similar to MetS in the form of increased body weight and serum levels of glucose and insulin with an elevated HOMA-IR reflecting insulin resistance as well as dyslipidaemia. Lipid peroxidation (increased malondialdehyde) and oxidative stress (decreased superoxide dismutase) were implicated in this syndrome. This group exhibited a significant decrease in testicular weight and the levels of reproductive hormones (LH, FSH and testosterone). The pituitary gonadotrophs showed electron dense nuclei, large cytoplasmic vacuoles, destructed organelles in addition to decreased number of secretory granules. Furthermore, testicular specimens presented marked alterations. There were disorganised shrunken tubules with irregular basement membranes, reduced germinal epithelial thickness, vacuolations and degenerated mitochondria in the spermatogenic cells. Beclin 1 and proliferating cell nuclear antigen immunoexpressions were significantly downregulated with HFrD-induced MetS. Ginger extract supplementation proved to be a potent protective agent against these harmful effects through its antioxidant, hypoglycaemic, insulinotropic, androgenic and hypolipidaemic effects in addition to its ability to induce testicular autophagy.
   Conclusions: Consumption of HFrD induced MetS and proved to have harmful effects on the pituitary-testicular axis. Moreover, this work provided a new insight into the possible use of ginger extract to alleviate the main features of MetS and protect the pituitary-gonadal axis from the damaging effects of HFrD-induced MetS.
C1 [El-Mehi, A. E.; Faried, M. A.] Menoufia Univ, Fac Med, Anat & Embryol Dept, Al Minufya, Egypt.
C3 Egyptian Knowledge Bank (EKB); Menofia University
RP Faried, MA (corresponding author), Menoufia Univ, Fac Med, Anat & Embryol Dept, Al Minufya, Egypt.
EM manarfaried@med.menofia.edu.eg
RI El-Mehi, Abeer/AAG-6547-2021; Faried, Manar/AAY-3280-2021
OI El- Mehi, Abeer/0000-0002-3549-3162
CR Abarikwu SO, 2012, J BIOCHEM MOL TOXIC, V26, P477, DOI 10.1002/jbt.21449
   Abdel-Dayem M., 2009, EGYPTIAN J HISTOLOGY, V32, P81
   Afzali A, 2018, BIOSCI BIOTECHNO RES, V11, P181, DOI 10.21786/bbrc/11.1/25
   Aguilera-Mendez A, 2018, NUTR RES, V57, P86, DOI 10.1016/j.nutres.2018.06.007
   Ahmed Rafat S., 2000, Indian Journal of Experimental Biology, V38, P604
   Akimoto M, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0126605
   Al-Amin ZM, 2006, BRIT J NUTR, V96, P660, DOI 10.1079/BJN20061849
   Al-Hamad D, 2017, TRANSL PEDIATR, V6, P397, DOI 10.21037/tp.2017.10.02
   Al-Noory AS, 2013, PHARMACOGN RES, V5, P157, DOI 10.4103/0974-8490.112419
   Altabas V, 2013, CURR CLIN PHARMACOL, V8, P224, DOI 10.2174/1574884711308030009
   Alten B, 2018, BRIT J PHARMACOL, V175, P4450, DOI 10.1111/bph.14500
   Amin A, 2006, ASIAN J ANDROL, V8, P607, DOI 10.1111/j.1745-7262.2006.00179.x
   Anan H.H., 2017, Int J Sci Rep, V3, P39
   [Anonymous], 2007, Journal of Cell and Molecular Biology
   Arikawe A P, 2012, Niger J Physiol Sci, V27, P171
   Aydin S, 2014, NUTRITION, V30, P1, DOI 10.1016/j.nut.2013.05.013
   Baccetti B, 2002, HUM REPROD, V17, P2673, DOI 10.1093/humrep/17.10.2673
   Basaranoglu M, 2013, WORLD J GASTROENTERO, V19, P1166, DOI 10.3748/wjg.v19.i8.1166
   Bennetts LE, 2005, MOL REPROD DEV, V71, P77, DOI 10.1002/mrd.20285
   Carrier A, 2017, ANTIOXID REDOX SIGN, V26, P429, DOI 10.1089/ars.2016.6929
   Cha KM, 2018, J FUNCT FOODS, V40, P736, DOI 10.1016/j.jff.2017.12.008
   Chandramohan R., 2014, BIOMED AGING PATHOL, V4, P23, DOI [10.1016/j.biomag.2013.12.003, DOI 10.1016/J.BIOMAG.2013.12.003]
   Corona G, 2007, J SEX MED, V4, P1038, DOI 10.1111/j.1743-6109.2007.00529.x
   Crescenzo R, 2014, EUR J NUTR, V53, P413, DOI 10.1007/s00394-013-0538-2
   Darbandi M, 2018, REPROD BIOL ENDOCRIN, V16, DOI 10.1186/s12958-018-0406-2
   de Lamirande E, 1997, Rev Reprod, V2, P48, DOI 10.1530/revreprod/2.1.48
   Denton D, 2015, IMMUNOL CELL BIOL, V93, P35, DOI 10.1038/icb.2014.85
   Gao FY, 2018, J CELL BIOL, V217, P2103, DOI 10.1083/jcb.201710078
   Gao HQ, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/570948
   Gastaldelli A, 2007, AM J PHYSIOL-ENDOC M, V292, pE871, DOI 10.1152/ajpendo.00551.2006
   Harrell CS, 2015, PSYCHONEUROENDOCRINO, V62, P252, DOI 10.1016/j.psyneuen.2015.08.025
   Haubitz M., 2007, Transplantationsmedizin, V19, P26
   Hung JY, 2009, J AGR FOOD CHEM, V57, P9809, DOI 10.1021/jf902315e
   Guzmán-Gerónimo RI, 2017, J MED FOOD, V20, P110, DOI [10.1089/jmf.2016.0087, 10.1089/jmf.2016.3851]
   Jang S, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/5936402
   Johnson RJ, 2007, AM J CLIN NUTR, V86, P899
   Kamtchouing P, 2002, ASIAN J ANDROL, V4, P299
   Khandouzi N, 2015, IRAN J PHARM RES, V14, P131
   Kim I, 2007, ARCH BIOCHEM BIOPHYS, V462, P245, DOI 10.1016/j.abb.2007.03.034
   Kyathanahalli C, 2014, J DIABETES, V6, P48, DOI 10.1111/1753-0407.12068
   Lavezzi AM, 2000, IN VIVO, V14, P447
   Li TY, 2017, BIOMED PHARMACOTHER, V93, P208, DOI 10.1016/j.biopha.2017.06.038
   Li YM, 2012, PLANTA MED, V78, P1549, DOI 10.1055/s-0032-1315041
   Li ZM, 2019, CHEM-BIOL INTERACT, V297, P119, DOI 10.1016/j.cbi.2018.10.013
   Lin J, 2014, B KOREAN CHEM SOC, V35, P1633, DOI 10.5012/bkcs.2014.35.6.1633
   Lirdi LC, 2008, ANAT REC, V291, P797, DOI 10.1002/ar.20693
   Liu C, 2017, WORLD J GASTROENTERO, V23, P1964, DOI 10.3748/wjg.v23.i11.1964
   Ly Xue, 2007, J REPROD CONTRACEPT, V18, P181, DOI 10.1016/s1001- 7844(07)60022-4.
   MADDOCKS S, 1988, J PHYSIOL-LONDON, V407, P363, DOI 10.1113/jphysiol.1988.sp017420
   Malekinejad H, 2011, HUM EXP TOXICOL, V30, P110, DOI 10.1177/0960327110368416
   Mamikutty N, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/263897
   Maneesh M, 2006, INDIAN J CLIN BIOCHE, V21, P165, DOI 10.1007/BF02913088
   Meydanli EG, 2018, ULTRASTRUCT PATHOL, V42, P65, DOI 10.1080/01913123.2017.1397075
   Mohamed D., 2014, BR J SCI, V11, P72
   Moreno-Fernández S, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101502
   MURPHY CJ, 2014, SPERMATOGENESIS, V2, DOI DOI 10.1177/2050313X14550359
   Naidu JR, 2018, INT RES J PHARM MED, V1, P37
   Narayanan JM, 2016, GEN PHYSIOL BIOPHYS, V35, P185, DOI 10.4149/gpb_2015041
   Oluwatoyin A, 2014, Science Journal of Chemistry, V2, P44, DOI [10.11648/j.sjc.20140206.11, DOI 10.11648/J.SJC.20140206.11]
   Platel K, 2000, NAHRUNG, V44, P42, DOI 10.1002/(SICI)1521-3803(20000101)44:1<42::AID-FOOD42>3.0.CO;2-D
   Prabhakar P, 2015, EUR J NUTR, V54, P1117, DOI 10.1007/s00394-014-0788-7
   Putakala M, 2017, BIOMED PHARMACOTHER, V95, P1359, DOI 10.1016/j.biopha.2017.09.054
   Ramakrishna C, 2015, RES J PHARM BIOL CHE, V6, P961
   Robeva R, 2012, ANDROLOGIA, V44, P329, DOI 10.1111/j.1439-0272.2011.01185.x
   Russell LD., 1993, Int. J. Androl., V16, P83, DOI DOI 10.1111/J.1365-2605.1993.TB01156.X
   Sakr Saber A., 2003, ScienceAsia, V29, P327, DOI 10.2306/scienceasia1513-1874.2003.29.327
   Salama N, 2003, EUR UROL, V43, P84, DOI 10.1016/S0302-2838(02)00501-8
   Sekiwa Y, 2000, J AGR FOOD CHEM, V48, P373, DOI 10.1021/jf990674x
   Shalaby MA, 2010, FOOD CHEM TOXICOL, V48, P2920, DOI 10.1016/j.fct.2010.07.028
   Shanmugam KR, 2011, FOOD CHEM TOXICOL, V49, P893, DOI 10.1016/j.fct.2010.12.013
   Sharma RK, 1996, UROLOGY, V48, P835, DOI 10.1016/S0090-4295(96)00313-5
   Shawky NM, 2019, ENVIRON TOXICOL PHAR, V66, P43, DOI 10.1016/j.etap.2018.12.008
   Spear LP, 2000, NEUROSCI BIOBEHAV R, V24, P417, DOI 10.1016/S0149-7634(00)00014-2
   Srikumar S, 2005, J ENVIRON BIOL, V26, P567
   Suga A, 2000, AM J PHYSIOL-ENDOC M, V278, pE677, DOI 10.1152/ajpendo.2000.278.4.E677
   Sugandhy O, 2011, 10 INT C MERC GLOB P, V29, P45
   Sun SZ, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-89
   Tang Z, 2017, TESTES OVARIES FUNCT, DOI [10.5772/67878, DOI 10.5772/67878]
   Tappy L, 2010, NUTRITION, V26, P1044, DOI 10.1016/j.nut.2010.02.014
   Tappy L, 2010, PHYSIOL REV, V90, P23, DOI 10.1152/physrev.00019.2009
   Triplitt C, 2010, VASC HEALTH RISK MAN, V6, P671
   Ulu R, 2018, FOOD CHEM TOXICOL, V118, P526, DOI 10.1016/j.fct.2018.05.061
   Ventimiglia E, 2016, ANDROLOGY-US, V4, P944, DOI 10.1111/andr.12232
   Vos Miriam B, 2008, Medscape J Med, V10, P160
   Wang J, 2019, J NUTR BIOCHEM, V70, P105, DOI 10.1016/j.jnutbio.2019.05.001
   Xu ML, 2016, ENVIRON TOXICOL, V31, P1731, DOI 10.1002/tox.22175
   Yamamoto CM, 2001, J ANDROL, V22, P981
   Yen GC, 2003, FOOD CHEM, V83, P49, DOI 10.1016/S0308-8146(03)00035-9
   Yousaf B, 2016, ENVIRON SCI POLLUT R, V23, P11645, DOI 10.1007/s11356-016-6330-0
   Zakaria S., 2017, B EGYPTIAN SOC PHYSL, V37, P208, DOI [10.21608/besps.2017.8268, DOI 10.21608/BESPS.2017.8268]
   Zhang YL, 2017, ENVIRON TOXICOL PHAR, V55, P137, DOI 10.1016/j.etap.2017.07.014
NR 91
TC 10
Z9 10
U1 0
U2 5
PU VIA MEDICA
PI GDANSK
PA UL SWIETOKRZYSKA 73, 80-180 GDANSK, POLAND
SN 0015-5659
EI 1644-3284
J9 FOLIA MORPHOL
JI Folia Morphol.
PY 2020
VL 79
IS 4
BP 690
EP 708
DI 10.5603/FM.a2019.0139
PG 19
WC Anatomy & Morphology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anatomy & Morphology
GA PA9DW
UT WOS:000595928900004
PM 31886878
OA gold
DA 2025-06-11
ER

PT J
AU Padiya, R
   Khatua, TN
   Bagul, PK
   Kuncha, M
   Banerjee, SK
AF Padiya, Raju
   Khatua, Tarak N.
   Bagul, Pankaj K.
   Kuncha, Madhusudana
   Banerjee, Sanjay K.
TI Garlic improves insulin sensitivity and associated metabolic syndromes
   in fructose fed rats
SO NUTRITION & METABOLISM
LA English
DT Article
DE Allium sativum L.; garlic; Fructose; Diabetes; Metabolic syndrome;
   Nitric oxide; Hydrogen sulphide; oxidative stress
ID HYDROGEN-SULFIDE; WEIGHT-GAIN; RESISTANCE; HYPERTENSION; ANTIOXIDANTS;
   EPIDEMIC; ALLICIN; OXIDE; OIL
AB Background: Type 2 diabetes mellitus, characterized by peripheral insulin resistance, is a major lifestyle disorder of the 21(st) Century. Raw garlic homogenate has been reported to reduce plasma glucose levels in animal models of type 1 diabetes mellitus. However, no specific studies have been conducted to evaluate the effect of raw garlic on insulin resistance or type 2 diabetes mellitus. This study was designed to investigate the effect of raw garlic on fructose induced insulin resistance, associated metabolic syndrome and oxidative stress in diabetic rats.
   Methods: Male Sprague Dawley rats weighing 200-250 gm body weight were divided into 3 groups (n = 7 per group) and fed diet containing 65% cornstarch (Control group) and 65% fructose (Diabetic group) for 8 weeks. The third group (Dia+Garl group) was fed both 65% fructose and raw garlic homogenate (250 mg/kg/day) for 8 weeks. Whole garlic cloves were homogenized with water to make a fresh paste each day.
   Results: At the end of 8 weeks, serum glucose, insulin, triglyceride and uric acid levels, as well as insulin resistance, as measured by glucose tolerance test, were significantly (p < 0.01) increased in fructose fed rats (Diabetic group) when compared to the cornstarch fed (Control) rats. Administration of raw garlic to fructose fed rats (Dia+Garl group) significantly (p < 0.05) reduced serum glucose, insulin, triglyceride and uric acid levels, as well as insulin resistance when compared with fructose fed rats. Garlic also normalised the increased serum levels of nitric oxide (NO) and decreased levels of hydrogen sulphide (H2S) after fructose feeding. Although body weight gain and serum glycated haemoglobin levels of fructose fed rats (Diabetic group) were not significantly different from control rats, significant (p < 0.05) reduction of these parameters was observed in fructose fed rats after garlic administration (Dia+Garl group). Significant (p < 0.05) increase in TBARS and decrease in GSH was observed in diabetic liver. Catalase was not significantly affected in any of the groups. Administration of raw garlic homogenate normalised both hepatic TBARS and GSH levels.
   Conclusions: Our study demonstrates that raw garlic homogenate is effective in improving insulin sensitivity while attenuating metabolic syndrome and oxidative stress in fructose-fed rats.
C1 [Padiya, Raju; Khatua, Tarak N.; Bagul, Pankaj K.; Kuncha, Madhusudana; Banerjee, Sanjay K.] Indian Inst Chem Technol, Div Pharmacol & Chem Biol, Hyderabad 500607, Andhra Pradesh, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Indian Institute of Chemical Technology (IICT)
RP Banerjee, SK (corresponding author), Indian Inst Chem Technol, Div Pharmacol & Chem Biol, Hyderabad 500607, Andhra Pradesh, India.
EM skbanerjee@iict.res.in
RI Dr. Pankaj K. Bagul, M.S/I-3867-2012
OI , Raju Padiya/0000-0002-9772-9118; Banerjee, Sanjay/0000-0002-0008-0480;
   , Tarak Nath Khatua/0009-0002-0797-5137; Banerjee, Sanjay
   k/0000-0002-0044-0984
FU Department of Biotechnology (DBT); Indian Council of Medical Research
   (ICMR); Council of Scientific and Industrial Research (CSIR), Govt. of
   India; IICT institute
FX Financial support was provided by Ramalingaswami Fellowship fund (SKB)
   from Department of Biotechnology (DBT), Junior Research Fellowship (RP)
   from Indian Council of Medical Research (ICMR), and Senior Research
   Fellowship (TNK) from Council of Scientific and Industrial Research
   (CSIR), Govt. of India and IICT institute fund. We wish to thank Dr J S
   Yadav, Director, IICT, Hyderabad for providing all kind of support for
   this work and gratefully acknowledge Dr Mohua Maulik for her suggestions
   and critical review of the manuscript.
CR Abd El-Gawad H, 2004, J BIOCHEM MOL TOXIC, V18, P69, DOI 10.1002/jbt.20013
   Abdullah MM, 2009, MOL CELL BIOCHEM, V327, P247, DOI 10.1007/s11010-009-0063-z
   AEBI H, 1974, METHOD ENZYMAT AN, V4, P673
   Asdaq SMB, 2011, J NAT MED-TOKYO, V65, P81, DOI 10.1007/s11418-010-0467-9
   Banerjee SK, 2002, NUTR J, V1, DOI 10.1186/1475-2891-1-4
   Banerjee SK, 2002, LIFE SCI, V70, P1509, DOI 10.1016/S0024-3205(01)01514-4
   Banerjee SK, 2001, FOOD CHEM TOXICOL, V39, P793, DOI 10.1016/S0278-6915(01)00018-7
   Bray GA, 2004, AM J CLIN NUTR, V79, P537
   Bray GA, 2007, AM J CLIN NUTR, V86, P895, DOI 10.1093/ajcn/86.4.895
   BRUCKDORFER KR, 1973, P NUTR SOC, V32, pA12
   Cai WJ, 2007, CARDIOVASC RES, V76, P29, DOI 10.1016/j.cardiores.2007.05.026
   CARSON J F, 1987, Food Reviews International, V3, P71
   Chiarelli F, 2000, DIABETES, V49, P1258, DOI 10.2337/diabetes.49.7.1258
   Eidi A, 2006, PHYTOMEDICINE, V13, P624, DOI 10.1016/j.phymed.2005.09.010
   Elkayam A, 2003, AM J HYPERTENS, V16, P1053, DOI 10.1016/j.amjhyper.2003.07.011
   Elliott SS, 2002, AM J CLIN NUTR, V76, P911, DOI 10.1093/ajcn/76.5.911
   ELLMAN GL, 1959, ARCH BIOCHEM BIOPHYS, V82, P70, DOI 10.1016/0003-9861(59)90090-6
   Everson SA, 1998, DIABETES CARE, V21, P1637, DOI 10.2337/diacare.21.10.1637
   FARVA D, 1986, INDIAN J BIOCHEM BIO, V23, P24
   JAIN RC, 1975, AM J CLIN NUTR, V28, P684, DOI 10.1093/ajcn/28.7.684
   Jain SK, 2010, ANTIOXID REDOX SIGN, V12, P1333, DOI 10.1089/ars.2009.2956
   Jalal R, 2007, J CLIN BIOCHEM NUTR, V41, P218, DOI 10.3164/jcbn.2007031
   Johnson RJ, 2007, AM J CLIN NUTR, V86, P899
   Johnson RJ, 2009, ENDOCR REV, V30, P96, DOI 10.1210/er.2008-0033
   King H, 1998, DIABETES CARE, V21, P1414, DOI 10.2337/diacare.21.9.1414
   Kumar G. Rajender, 1999, Indian Journal of Experimental Biology, V37, P662
   Liu CT, 2005, EUR J PHARMACOL, V516, P165, DOI 10.1016/j.ejphar.2005.04.031
   Madkor HR, 2011, BRIT J NUTR, V105, P1210, DOI 10.1017/S0007114510004927
   Maki KC, 2004, AM J CARDIOL, V93, p12C, DOI 10.1016/j.amjcard.2004.02.001
   MANCARDI D, CURR PHARM BIOTECHNO
   Maritim AC, 2003, J BIOCHEM MOL TOXIC, V17, P24, DOI 10.1002/jbt.10058
   MARTINEZ FJ, 1994, HYPERTENSION, V23, P456, DOI 10.1161/01.HYP.23.4.456
   MATHEW PT, 1973, INDIAN J BIOCHEM BIO, V10, P209
   Mattapally S, 2011, IIOAB J, V2, P29
   Nakagawa T, 2006, AM J PHYSIOL-RENAL, V290, pF625, DOI 10.1152/ajprenal.00140.2005
   Ohaeri OC, 2001, BIOSCIENCE REP, V21, P19, DOI 10.1023/A:1010425932561
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   Reungjui S, 2007, J AM SOC NEPHROL, V18, P2724, DOI 10.1681/ASN.2007040416
   Riccardi G, 2000, BRIT J NUTR, V83, pS143
   Rosenthal T., 2001, American Journal of Hypertension, V14, p219A, DOI 10.1016/S0895-7061(01)01872-6
   THORBURN AW, 1989, AM J CLIN NUTR, V49, P1155, DOI 10.1093/ajcn/49.6.1155
   Veerapur VP, 2010, INDIAN J EXP BIOL, V48, P800
   Whiteman M, 2010, DIABETOLOGIA, V53, P1722, DOI 10.1007/s00125-010-1761-5
NR 43
TC 108
Z9 116
U1 0
U2 29
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD JUL 27
PY 2011
VL 8
AR 53
DI 10.1186/1743-7075-8-53
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 816ML
UT WOS:000294605000001
PM 21794123
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Konikowska, K
   Bombala, W
   Szuba, A
   Rózanska, D
   Regulska-Ilow, B
AF Konikowska, Klaudia
   Bombala, Wojciech
   Szuba, Andrzej
   Rozanska, Dorota
   Regulska-Ilow, Bozena
TI Metabolic Syndrome Is Associated with Low Diet Quality Assessed by the
   Healthy Eating Index-2015 (HEI-2015) and Low Concentrations of
   High-Density Lipoprotein Cholesterol
SO BIOMEDICINES
LA English
DT Article
DE metabolic syndrome; diet; diet quality; nutrition; HEI-2015
ID CARDIOVASCULAR RISK-FACTORS; CORONARY-HEART-DISEASE; FATTY-ACIDS;
   WEIGHT-LOSS; METAANALYSIS; MANAGEMENT; PROTEIN; STRESS; IMPACT; ADULTS
AB Presenting diet quality of patients with metabolic syndrome (MetS), using a holistic approach is more useful than investigating dietary individual components, but there is still a small amount of research in this area. The aim of this study assessed the diet quality, as measured by the HEI-2015, of MetS patients compared to healthy individuals. The study and control group consisted of 215 patients with MetS and 320 people without MetS, respectively. A nutritional analysis using a semi-quantitative food frequency questionnaire was used to evaluate the nutritional habits in the study and control group. Total HEI-2015 scores were significantly lower in MetS subjects than in those in the control group (65.04 +/- 9.71 vs. 66.75 +/- 8.88) and the quality of women's diets was better than the quality of men's diet (66.83 +/- 8.99 vs. 64.75 +/- 9.57). We also observed that low HDL-c concentration increased the risk of MetS in the general population the most. Across the population, there was a weak positive correlation between HDL-c concentrations and total HEI-2015 scores and a weak negative correlation between mean waist circumference values and total HEI-2015 scores. HDL-c concentrations may be a key factor in the prevention of MetS and appropriate therapeutic management to increase HDL-c levels may be of key importance in patients diagnosed with MetS.
C1 [Konikowska, Klaudia; Rozanska, Dorota; Regulska-Ilow, Bozena] Wroclaw Med Univ, Dept Dietet, Borowska St 211, PL-50556 Wroclaw, Poland.
   [Bombala, Wojciech] Wroclaw Med Univ, Stat Anal Ctr, Marcinkowski St 2-6, PL-50368 Wroclaw, Poland.
   [Szuba, Andrzej] Wroclaw Med Univ, Dept Angiol Hypertens & Diabetol, Borowska St 213, PL-50556 Wroclaw, Poland.
C3 Wroclaw Medical University; Wroclaw Medical University; Wroclaw Medical
   University
RP Konikowska, K (corresponding author), Wroclaw Med Univ, Dept Dietet, Borowska St 211, PL-50556 Wroclaw, Poland.
EM klaudia.konikowska@umw.edu.pl
RI Różańska, Dorota/ABD-3220-2021; Szuba, Andrzej/AAY-1162-2020;
   Regulska-Ilow, Bożena/ABD-3301-2021; Rozanska, Dorota/S-5239-2018;
   Konikowska, Klaudia/AAZ-1828-2021
OI Regulska-Ilow, Bozena/0000-0002-5941-1715; Szuba,
   Andrzej/0000-0002-7555-6201; Rozanska, Dorota/0000-0002-0561-2749;
   Konikowska, Klaudia/0000-0003-0111-7617
CR Agarwal S, 2021, NUTRIENTS, V13, DOI 10.3390/nu13082614
   Al-Daghri NM, 2013, NUTRIENTS, V5, P4587, DOI 10.3390/nu5114587
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   [Anonymous], 2016, Dietary Guidelines for Americans, V8th
   Azemati B, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124296
   Bednarek-Tupikowska G., 2007, ENDOKRYNOL OTY ZAB P, V3, P55
   Berube LT, 2019, J ACAD NUTR DIET, V119, P1284, DOI 10.1016/j.jand.2019.02.004
   Boulangé CL, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0303-2
   Boutté AK, 2021, J ACAD NUTR DIET, V121, P1785, DOI 10.1016/j.jand.2021.02.025
   Byrne CS, 2015, INT J OBESITY, V39, P1331, DOI 10.1038/ijo.2015.84
   Catapano AL, 2016, KARDIOL POL, V74, P1234, DOI 10.5603/KP.2016.0157
   Chen JP, 2018, NUTRIENTS, V10, DOI 10.3390/nu10010024
   Chen PY, 2018, NUTRIENTS, V10, DOI 10.3390/nu10081113
   Cruz R.D., 2020, CURR DEV NUTR, V4, P318, DOI [10.1093/cdn/nzaa044_017, DOI 10.1093/CDN/NZAA044_017]
   Dehghan M, 2012, J HUM NUTR DIET, V25, P225, DOI 10.1111/j.1365-277X.2012.01240.x
   Edefonti V, 2022, J ACAD NUTR DIET, V122, P1677, DOI 10.1016/j.jand.2021.04.020
   Edwards CG, 2021, NUTR NEUROSCI, V24, P269, DOI 10.1080/1028415X.2019.1623456
   Fardet A, 2016, FOOD FUNCT, V7, P2338, DOI [10.1039/c6fo00107f, 10.1039/C6FO00107F]
   Gadgil MD, 2015, J NUTR, V145, P1211, DOI 10.3945/jn.114.207753
   Gayet-Boyer C, 2014, BRIT J NUTR, V112, P1914, DOI 10.1017/S0007114514002578
   Guembe MJ, 2020, CARDIOVASC DIABETOL, V19, DOI 10.1186/s12933-020-01166-6
   Zadeh SH, 2021, NUTR FOOD SCI, V51, P749, DOI 10.1108/NFS-04-2020-0146
   Hooper L, 2015, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD011737, 10.1002/14651858.CD011737.pub2]
   Hosseini-Esfahani F, 2018, INT J ENDOCRINOL MET, V16, DOI 10.5812/ijem.84772
   Hoyas I, 2019, J CLIN MED, V8, DOI 10.3390/jcm8091301
   Julibert A, 2019, NUTR METAB CARDIOVAS, V29, P887, DOI 10.1016/j.numecd.2019.05.055
   Kastorini CM, 2011, J AM COLL CARDIOL, V57, P1299, DOI 10.1016/j.jacc.2010.09.073
   Kelley GA, 2009, PREV MED, V48, P9, DOI 10.1016/j.ypmed.2008.10.010
   Khodarahmi M, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0219193
   Kim K, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-91312-1
   Krebs-Smith S, 2015, FASEB J, V29
   Krebs-Smith SM, 2018, J ACAD NUTR DIET, V118, P1591, DOI 10.1016/j.jand.2018.05.021
   Kunachowicz H., 2019, FOOD COMPOSITION NUT, V2nd
   Leung CW, 2019, J ACAD NUTR DIET, V119, P1676, DOI 10.1016/j.jand.2018.10.011
   Lin Y, 2011, BRIT J NUTR, V105, P1106, DOI 10.1017/S0007114510004642
   Liu XT, 2015, BMC PUBLIC HEALTH, V15, DOI 10.1186/s12889-015-1747-9
   Luecking CT, 2020, J ACAD NUTR DIET, V120, P386, DOI 10.1016/j.jand.2019.09.018
   Ma CM, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-10446-3
   Mach F, 2020, EUR HEART J, V41, P111, DOI 10.1093/eurheartj/ehz455
   Maeda K, 2003, PREV MED, V37, P283, DOI 10.1016/S0091-7435(03)00110-5
   Mani P, 2017, DIAB MET SYND CLIN R, V11, pS175, DOI 10.1016/j.dsx.2016.12.028
   Souza JDM, 2019, J ACAD NUTR DIET, V119, P1866, DOI 10.1016/j.jand.2019.04.014
   McClure ST, 2020, BMJ OPEN DIAB RES CA, V8, DOI 10.1136/bmjdrc-2020-001681
   McEwen B, 2010, DIABETES EDUCATOR, V36, P565, DOI 10.1177/0145721710372675
   Mensink R., 2016, EFFECTS SATURATED FA
   Micha R, 2010, CIRCULATION, V121, P2271, DOI 10.1161/CIRCULATIONAHA.109.924977
   Monserrat-Mesquida M, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9030236
   Mozaffarian D, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000252
   National Cancer Institute, VISUALIZATION INTERP
   Nordmann AJ, 2006, ARCH INTERN MED, V166, P285, DOI 10.1001/archinte.166.3.285
   Orchard TS, 2018, J ACAD NUTR DIET, V118, P578, DOI 10.1016/j.jand.2017.09.024
   Pacholczyk M, 2008, POSTEP HIG MED DOSW, V62, P530
   Palkowska Ewelina, 2012, Rocz Panstw Zakl Hig, V63, P163
   Panizza CE, 2018, NUTRIENTS, V10, DOI 10.3390/nu10040452
   Pérez-Tepayo S, 2020, NUTR J, V19, DOI 10.1186/s12937-020-00568-2
   Raffoul A, 2021, J ACAD NUTR DIET, V121, P942, DOI 10.1016/j.jand.2020.10.011
   Reedy J, 2018, J ACAD NUTR DIET, V118, P1622, DOI 10.1016/j.jand.2018.05.019
   Richter CK, 2015, ADV NUTR, V6, P712, DOI 10.3945/an.115.009654
   Rimm EB, 1999, BMJ-BRIT MED J, V319, P1523, DOI 10.1136/bmj.319.7224.1523
   Shaw K, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003817.pub3
   Soliman GA, 2019, NUTRIENTS, V11, DOI 10.3390/nu11051155
   Steele EM, 2019, PREV MED, V125, P40, DOI 10.1016/j.ypmed.2019.05.004
   Sun YB, 2018, J ACAD NUTR DIET, V118, P1855, DOI 10.1016/j.jand.2018.03.017
   Szponar L., 2000, Album of Photographs of Food Products and Dishes
   Timóteo AT, 2018, REV PORT CARDIOL, V37, P1001, DOI 10.1016/j.repc.2017.11.013
   Viguiliouk E, 2019, CLIN NUTR, V38, P1133, DOI 10.1016/j.clnu.2018.05.032
   Wang K, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020348
   WHO Consultation, 2000, WHO TECH REP SER, V894, P1
   Xu HY, 2022, DIABETOL METAB SYNDR, V14, DOI 10.1186/s13098-022-00793-1
   Zhubi-Bakija F, 2021, CLIN NUTR, V40, P255, DOI 10.1016/j.clnu.2020.05.017
   Zinöcker MK, 2018, NUTRIENTS, V10, DOI 10.3390/nu10030365
   Zomer E, 2016, OBES REV, V17, P1001, DOI 10.1111/obr.12433
NR 73
TC 15
Z9 16
U1 0
U2 11
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD OCT
PY 2022
VL 10
IS 10
AR 2487
DI 10.3390/biomedicines10102487
PG 17
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA 5O3RW
UT WOS:000872395800001
PM 36289749
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Peng, XM
   Huang, JJ
   Xia, SS
   Yang, Y
   Dong, K
AF Peng, Xuemin
   Huang, Jiaojiao
   Xia, Sanshan
   Yang, Yan
   Dong, Kun
TI Association of leukocyte telomere length with metabolic syndrome in type
   2 diabetes mellitus
SO JOURNAL OF RESEARCH IN MEDICAL SCIENCES
LA English
DT Article
DE Metabolic syndrome; telomere; type 2 diabetes mellitus
ID OXIDATIVE STRESS; PREVALENCE; RISK; MARKERS; OBESITY; DISEASE
AB Background: Leukocyte telomere length (LTL) has been revealed to be associated with aging-related diseases such as metabolic syndrome (MetS) and Type 2 diabetes mellitus (T2DM). We aimed to investigate the correlation of LTL with MetS and its components in T2DM patients in this cross-sectional study. Materials and Methods: A total of 344 T2DM patients were enrolled into this study. LTL was measured by Southern blot-based terminal restriction fragment length analysis. MetS was clinically defined by 2007 Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults. Results: Of 344 T2DM patients, 53% had MetS. T2DM patients with MetS had significantly longer LTL than those without MetS (6451.95 +/- 51.10 base pairs vs. 6076.13 +/- 55.13 base pairs, P < 0.001), especially when T2DM patients had poor glycemic control (hemoglobin A1c >= 7%). Meanwhile, the trend of longer LTL was associated with the increased components of MetS in T2DM patient. Finally, LTL had a significant association with MetS (odds ratio [OR]: 2.096, 95% confidence interval [CI] 1.337-3.285, P = 0.001), low levels of high-density lipoprotein-cholesterol (HDL-C) (OR: 2.412, 95% CI 1.350-4.308, P = 0.003) in T2DM patients. Conclusion: T2DM patients with MetS had a significantly longer LTL than those without MetS. The longer LTL was especially evident in T2DM patients with poor glycemic control. Longer LTL was positively associated with MetS, particularly low levels of HDL-C in T2DM patients.
C1 [Peng, Xuemin; Huang, Jiaojiao; Xia, Sanshan; Yang, Yan; Dong, Kun] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Endocrinol, Wuhan, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology
RP Dong, K (corresponding author), 1095 Jiefang Ave, Wuhan 430030, Hubei, Peoples R China.
EM kundong2019@hotmail.com
FU National Natural Science Foundation of China [81670754, 81600661]
FX This study was financially supported by grants from the National Natural
   Science Foundation of China (Nos. 81670754 and 81600661).
CR Anonymous, 2007, Zhonghua Xinxueguanbing Zazhi, V35, P390
   Appleby S, 2017, AM J HUM BIOL, V29, DOI 10.1002/ajhb.22906
   Bekaert S, 2007, AGING CELL, V6, P639, DOI 10.1111/j.1474-9726.2007.00321.x
   Chen W, 2009, ATHEROSCLEROSIS, V205, P620, DOI 10.1016/j.atherosclerosis.2009.01.021
   Chen YF, 2019, LIPIDS HEALTH DIS, V18, DOI 10.1186/s12944-019-1030-7
   Cheng YY, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0180687
   Ebrahimi H, 2019, J RES MED SCI, V24, DOI 10.4103/jrms.JRMS_858_18
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Fani L, 2020, J ALZHEIMERS DIS, V73, P707, DOI 10.3233/JAD-190759
   Goli P, 2020, J RES MED SCI, V25, DOI 10.4103/jrms.JRMS_733_19
   Hovatta I, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034948
   Molli AEI, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0174945
   Jones DA, 2014, DIABETES RES CLIN PR, V106, P627, DOI 10.1016/j.diabres.2014.09.054
   Khalangot MD, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00128
   Krasnienkov DS, 2018, EXP GERONTOL, V110, P247, DOI 10.1016/j.exger.2018.06.027
   Liu JH, 2019, AGING-US, V11, P741, DOI 10.18632/aging.101781
   Luu HN, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0221697
   Mehta NN, 2011, AM J CARDIOL, V107, P406, DOI 10.1016/j.amjcard.2010.09.035
   Nordfjäll K, 2008, OBESITY, V16, P2682, DOI 10.1038/oby.2008.413
   Ojeda-Rodriguez A, 2020, APPL PHYSIOL NUTR ME, V1, P1
   Rentoukas E, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035739
   Révész D, 2018, J CLIN ENDOCR METAB, V103, P148, DOI 10.1210/jc.2017-01625
   Révész D, 2015, J CLIN ENDOCR METAB, V100, P3050, DOI 10.1210/JC.2015-1995
   Révész D, 2014, J CLIN ENDOCR METAB, V99, P4607, DOI 10.1210/jc.2014-1851
   Rivera T, 2017, NAT STRUCT MOL BIOL, V24, P30, DOI 10.1038/nsmb.3335
   Sun YH, 2015, CARCINOGENESIS, V36, P1327, DOI 10.1093/carcin/bgv133
   Verma S, 2018, J DIABETES METAB DIS, V17, P149, DOI 10.1007/s40200-018-0354-6
   Von Zglinicki T, 2000, ANN NY ACAD SCI, V908, P99, DOI 10.1111/j.1749-6632.2000.tb06639.x
   von Zglinicki T, 2002, TRENDS BIOCHEM SCI, V27, P339, DOI 10.1016/S0968-0004(02)02110-2
   Weng NP, 1996, J EXP MED, V183, P2471, DOI 10.1084/jem.183.6.2471
   Weng NP, 1997, P NATL ACAD SCI USA, V94, P10827, DOI 10.1073/pnas.94.20.10827
   Whiting DR, 2011, DIABETES RES CLIN PR, V94, P311, DOI 10.1016/j.diabres.2011.10.029
NR 32
TC 6
Z9 7
U1 0
U2 11
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 1735-1995
EI 1735-7136
J9 J RES MED SCI
JI J. Res. Med. Sci.
PD JAN-DEC
PY 2021
VL 26
IS 1
DI 10.4103/jrms.JRMS_793_20
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA TX6UH
UT WOS:000683224600001
PM 34484375
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Guo, XX
   Wang, O
   Wang, Y
   Wang, K
   Ji, BP
   Zhou, F
AF Guo, Xiaoxuan
   Wang, Ou
   Wang, Yong
   Wang, Kai
   Ji, Baoping
   Zhou, Feng
TI Phenolic acids alleviate high-fat and high-fructose diet-induced
   metabolic disorders in rats
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE high-fructose and high-fat diet; metabolic syndrome; phenolic acids
ID HEPATIC STEATOSIS; CAFFEIC ACID; MITOCHONDRIAL DYSFUNCTION; ANTIOXIDANT
   PROPERTIES; PROTOCATECHUIC ACID; LIPID-ACCUMULATION; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; CHLOROGENIC ACID; SKELETAL-MUSCLE
AB Phenolic acids are naturally occurring compounds with meritorious physiological activities. The purpose of this study was to compare the ameliorative effects of six common phenolic acids on diet-induced metabolic syndrome (MS) in rats. SD rats were fed with high-fat and high-fructose diet supplemented with equimolar concentration of individual phenolic acids for 13 weeks. Results showed that different phenolic acids ameliorated MS through different ways. Compared with other phenolic acids, caffeic acid exerted more comprehensive effect in alleviating MS, with significant effects in attenuating hyperlipidemia, elevating glucose tolerance, improving antioxidant status, and normalizing hepatic functions. Ellagic acid exhibited good performance in hypolipidemia, anti-inflammation, and reducing visceral fat. Gallic acid and -coumaric acid showed marked effects in regulating liver steatosis, while chlorogenic acid exhibited potential hepatic protective and anti-inflammatory abilities. These results will benefit the application of these phenolic acids in the development of functional food for MS population.
   Practical applicationsThe high morbidity of metabolic syndrome (MS) has driven people to seek for natural and safe compounds to maintain optimal health. Different phenolic acids were shown to ameliorate MS through different ways, which provides experimental basis for developing combinations or formulas of phenolic acids with more comprehensive effects. Conversely, caffeic acid showed relatively better effects in attenuating features of metabolic disorders, and was suggested for the future development of functional foods for the population with MS.
C1 [Guo, Xiaoxuan; Ji, Baoping; Zhou, Feng] China Agr Univ, Beijing Key Lab Funct Food Plant Resources, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China.
   [Wang, Ou] Chinese Ctr Dis Control & Prevent, Natl Inst Nutr & Hlth, Beijing 100050, Peoples R China.
   [Wang, Yong] Acad State Adm Grain, Beijing 100037, Peoples R China.
   [Wang, Kai] Chinese Acad Agr Sci, Inst Apicultural Res, Beijing 100093, Peoples R China.
C3 China Agricultural University; Chinese Center for Disease Control &
   Prevention; Institute of Apicultural Research, CAAS; Chinese Academy of
   Agricultural Sciences
RP Zhou, F (corresponding author), China Agr Univ, POB 294,17 Tsinghua East Rd, Beijing 100083, Peoples R China.
EM zf@cau.edu.cn
RI Wang, Ou/AAE-1806-2022; Wang, Kai/Q-6434-2018
OI Wang, Kai/0000-0003-0553-5293
FU National Natural Science Foundation of China [31571831]
FX National Natural Science Foundation of China, Grant/Award Number:
   31571831
CR [Anonymous], CAN J PHYSL PHARM
   Azay-Milhau J, 2013, J ETHNOPHARMACOL, V150, P755, DOI 10.1016/j.jep.2013.09.046
   Azuma K, 2000, J AGR FOOD CHEM, V48, P5496, DOI 10.1021/jf000483q
   CACCETTA RAA, 2000, THE AMERICAN JOURNAL, V71, P67
   Chandramohan R., 2014, BIOMED AGING PATHOL, V4, P23, DOI [10.1016/j.biomag.2013.12.003, DOI 10.1016/J.BIOMAG.2013.12.003]
   Chen JH, 1997, J AGR FOOD CHEM, V45, P2374, DOI 10.1021/jf970055t
   Cho AS, 2010, FOOD CHEM TOXICOL, V48, P937, DOI 10.1016/j.fct.2010.01.003
   Clark J. Derrell, 1997, ILAR J, V38, P41
   Dekker MJ, 2010, AM J PHYSIOL-ENDOC M, V299, pE685, DOI 10.1152/ajpendo.00283.2010
   Ekstedt M, 2006, HEPATOLOGY, V44, P865, DOI 10.1002/hep.21327
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   FERNANDEZPANCHO. M, 2008, CRITICAL REVIEWS IN, V48, P649, DOI DOI 10.1080/10408390701761845
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   Frühbeck G, 2001, AM J PHYSIOL-ENDOC M, V280, pE827, DOI 10.1152/ajpendo.2001.280.6.E827
   Hegarty BD, 2002, DIABETES, V51, P1477, DOI 10.2337/diabetes.51.5.1477
   Hsu CL, 2007, BRIT J NUTR, V98, P727, DOI 10.1017/S000711450774686X
   Jaiswal N, 2015, APOPTOSIS, V20, P930, DOI 10.1007/s10495-015-1128-y
   Jung UJ, 2006, J PHARMACOL EXP THER, V318, P476, DOI 10.1124/jpet.106.105163
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Kim JH, 2013, BIOSCI BIOTECH BIOCH, V77, P1595, DOI 10.1271/bbb.130167
   KROTKIEWSKI M, 1983, J CLIN INVEST, V72, P1150, DOI 10.1172/JCI111040
   Lei F, 2007, INT J OBESITY, V31, P1023, DOI 10.1038/sj.ijo.0803502
   Lei F, 2003, J CHROMATOGR B, V796, P189, DOI 10.1016/S1570-0232(03)00610-X
   Lepor N. E., 2012, REV CARDIOVASCULAR M, V14, P40
   Liu J, 2014, FOOD FUNCT, V5, P1038, DOI 10.1039/c3fo60524h
   Liu WH, 2010, J AGR FOOD CHEM, V58, P10247, DOI 10.1021/jf102379n
   Manach C, 2005, AM J CLIN NUTR, V81, p230S, DOI 10.1093/ajcn/81.1.230S
   Mantena SK, 2008, FREE RADICAL BIO MED, V44, P1259, DOI 10.1016/j.freeradbiomed.2007.12.029
   Marra F, 2008, TRENDS MOL MED, V14, P72, DOI 10.1016/j.molmed.2007.12.003
   Miller A, 2008, CURR OPIN GASTROEN, V24, P204, DOI 10.1097/MOG.0b013e3282f3f4c4
   PANCHAL SK, 2012, THE JOURNAL OF NUTRI, V142, P690, DOI DOI 10.3945/JN.111.153577
   Panchal SK, 2013, EUR J NUTR, V52, P559, DOI 10.1007/s00394-012-0358-9
   Panchal SK, 2011, J CARDIOVASC PHARM, V57, P51, DOI [10.1097/FJC.0b013e3181feb90a, 10.1097/FJC.0b013e31821b1379]
   Punithavathi VR, 2011, J BIOCHEM MOL TOXIC, V25, P68, DOI 10.1002/jbt.20360
   Ravussin E, 1997, J AM DIET ASSOC, V97, pS42, DOI 10.1016/S0002-8223(97)00728-1
   Rebollo A, 2012, WORLD J GASTROENTERO, V18, P6552, DOI 10.3748/wjg.v18.i45.6552
   Rutledge AC, 2007, NUTR REV, V65, pS13, DOI 10.1301/nr.2007.jun.S13-S23
   Sato Y, 2011, INT J PHARMACEUT, V403, P136, DOI 10.1016/j.ijpharm.2010.09.035
   Scalbert A, 2000, J NUTR, V130, p2073S, DOI 10.1093/jn/130.8.2073S
   Scazzocchio B, 2011, DIABETES, V60, P2234, DOI 10.2337/db10-1461
   SMART RC, 1986, CARCINOGENESIS, V7, P1663, DOI 10.1093/carcin/7.10.1663
   Tappy L, 2010, NUTRITION, V26, P1044, DOI 10.1016/j.nut.2010.02.014
   Wang O, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0118135
   Yamauchi T, 2002, NAT MED, V8, P1288, DOI 10.1038/nm788
   You TJ, 2014, OBESITY, V22, P1679, DOI 10.1002/oby.20743
   Zhao YT, 2015, J AGR FOOD CHEM, V63, P4843, DOI 10.1021/acs.jafc.5b01246
   Zimmet P, 2001, NATURE, V414, P782, DOI 10.1038/414782a
NR 47
TC 12
Z9 12
U1 3
U2 51
PU WILEY-HINDAWI
PI LONDON
PA ADAM HOUSE, 3RD FL, 1 FITZROY SQ, LONDON, WIT 5HE, ENGLAND
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD DEC
PY 2017
VL 41
IS 6
AR e12419
DI 10.1111/jfbc.12419
PG 10
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA FO8FS
UT WOS:000417120500018
OA gold
DA 2025-06-11
ER

PT J
AU Gómez-Díaz, RA
   García-Bello, JA
   Mondragón-González, R
   Díaz-Flores, M
   Valladares-Salgado, A
   Gallardo, JM
   Talavera, JO
   Wacher, NH
AF Gomez-Diaz, Rita A.
   Antonio Garcia-Bello, Juan
   Mondragon-Gonzalez, Rafael
   Diaz-Flores, Margarita
   Valladares-Salgado, Adan
   Manuel Gallardo, Juan
   Talavera, Juan O.
   Wacher, Niels H.
TI Metabolic Syndrome in Children with Chronic Kidney Disease: PON1 and
   Treatment Modality
SO ARCHIVES OF MEDICAL RESEARCH
LA English
DT Article
DE Paraoxonase-1; SOD; PON1/HDL-cholesterol; Metabolic syndrome in
   children; CKD treatment modality
ID CHRONIC-RENAL-FAILURE; OXIDATIVE STRESS; PARAOXONASE-1 ACTIVITY;
   RISK-FACTORS; ADOLESCENTS; MORTALITY; OBESITY; HYPERLIPIDEMIA;
   INTERLEUKIN-6; POPULATION
AB Background and Aims. We undertook this study to evaluate the relationship between PON1, SOD and metabolic syndrome (MetS) in pediatric patients undergoing peritoneal dialysis, hemodialysis and patients in early stages of CKD.
   Methods. We carried out an analytical cross-sectional study of 134 children 6-17 years old. We registered anthropometric variables, vital signs, basic biochemical parameters, intact PTH (iPTH), high sensitivity CRP (hs-CRP), paraoxonase-1; SOD; PON1/HDL-cholesterol and homocysteine. For statistical analyses we used t test, Mann Whitney U test, x(2), Fisher exact test, linear or logistic regression models, using SPSS v.16.0. p values <0.05 were considered as significant.
   Results. There were 66 (49.3%) females; 39 (29.1%) had CKD stages 2-4 (predialysis), 42 (31.3%) on hemodialysis (HD) and 53 (39.6%) on automated peritoneal dialysis (PD). Time from diagnosis was 26 months. Significant differences were observed in mean, systolic and diastolic blood pressure, C-peptide, triglycerides, and HDL-cholesterol as well as PON1/HDL-cholesterol ratio and SOD.
   Conclusions. This study demonstrates that PON1 and SOD may be predictors for the presence of MetS in pediatric patients under treatment with peritoneal dialysis. The positive correlation observed in PON1/HDL-cholesterol ratio may reflect the protector effect of HDL-cholesterol in patients with CKD according with the modality of treatment. (C) 2013 IMSS. Published by Elsevier Inc.
C1 [Gomez-Diaz, Rita A.; Mondragon-Gonzalez, Rafael; Talavera, Juan O.; Wacher, Niels H.] UMAE Specialty Hosp, Ctr Med Nacl Siglo 21, IMSS, Med Res Unit Clin Epidemiol, Mexico City 06725, DF, Mexico.
   [Antonio Garcia-Bello, Juan] UMAE Gen Hosp Med Ctr La Raza, Nephrol Servis, IMSS, Mexico City, DF, Mexico.
   [Diaz-Flores, Margarita; Valladares-Salgado, Adan] UMAE Specialty Hosp, Ctr Med Nacl Siglo 21, IMSS, Med Res Unit Biochem, Mexico City 06725, DF, Mexico.
   [Manuel Gallardo, Juan] UMAE Specialty Hosp, Ctr Med Nacl Siglo 21, IMSS, Dis Res Unit Nephrol, Mexico City 06725, DF, Mexico.
C3 Instituto Mexicano del Seguro Social; Instituto Mexicano del Seguro
   Social; Instituto Mexicano del Seguro Social; Instituto Mexicano del
   Seguro Social
RP Gómez-Díaz, RA (corresponding author), UMAE Specialty Hosp, Ctr Med Nacl Siglo 21, IMSS, Med Res Unit Clin Epidemiol, Av Cuauhtemoc 330, Mexico City 06725, DF, Mexico.
EM ritagomezdiaz@netscape.net
RI Mondragon, Rafael/AAD-8567-2020; GALLARDO, Juan/HGF-1360-2022;
   gomez-diaz, rita/AAS-4030-2021; García, Antonio/HTO-1996-2023
OI Mondragon, Rafael/0000-0002-5673-3540; wacher,
   niels/0000-0002-7717-6704; DIAZ-FLORES, MARGARITA/0000-0001-9764-2701;
   GALLARDO, Juan Manuel/0000-0001-8833-4651; gomez-diaz,
   rita/0000-0002-2191-4931
CR Agrawal V, 2009, NAT REV NEPHROL, V5, P520, DOI 10.1038/nrneph.2009.114
   [Anonymous], 2000, Trading Economics
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Dounousi E, 2006, AM J KIDNEY DIS, V48, P752, DOI 10.1053/j.ajkd.2006.08.015
   Ece A, 2006, PEDIATR NEPHROL, V21, P239, DOI 10.1007/s00467-005-2079-2
   Efrat M, 2010, ADV EXP MED BIOL, V660, P153, DOI 10.1007/978-1-60761-350-3_14
   El-Behairy HF, 2013, J APPL SCI RES, V9, P2994
   Foley RN, 1998, J AM SOC NEPHROL, V9, pS16
   Garcia Bello JA, 2013, PEDIAT NEPHROL
   Goicoechea M, 2005, KIDNEY INT, V67, pS35, DOI 10.1111/j.1523-1755.2005.09308.x
   Gupta N, 2009, INDIAN J MED RES, V130, P361
   Hall JE, 2002, AM J MED SCI, V324, P127, DOI 10.1097/00000441-200209000-00003
   James MT, 2010, LANCET, V375, P1296, DOI 10.1016/S0140-6736(09)62004-3
   Kao MPC, 2010, J HUM HYPERTENS, V24, P1, DOI 10.1038/jhh.2009.70
   Kelishadi R, 2013, J RES MED SCI, V18, P178
   Koncsos P, 2010, PEDIATR RES, V67, P309, DOI 10.1203/PDR.0b013e3181c9fb66
   Kontush A, 2003, ARTERIOSCL THROM VAS, V23, P1881, DOI 10.1161/01.ATV.0000091338.93223.E8
   Kotur-Stevuljevic J, 2013, PEDIATR NEPHROL, V28, P295, DOI 10.1007/s00467-012-2323-5
   Krzystek-Korpacka M, 2013, ADV CLIN EXP MED, V22, P229
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Locatelli F, 2003, NEPHROL DIAL TRANSPL, V18, P1272, DOI 10.1093/ndt/gfg074
   Longenecker JC, 2002, J AM SOC NEPHROL, V13, P1918, DOI 10.1097/01.ASN.0000019641.41496.1E
   MCCORD JM, 1969, J BIOL CHEM, V244, P6049
   Murphy AJ, 2009, CURR MED CHEM, V16, P667, DOI 10.2174/092986709787458425
   National Heart Lung and Blood Institute, DIS COND IND WHAT IS
   Navaneethan SD, 2010, SEMIN NEPHROL, V30, P51, DOI 10.1016/j.semnephrol.2009.10.008
   Panichi V, 2004, NEPHROL DIAL TRANSPL, V19, P1154, DOI 10.1093/ndt/gfh052
   Paragh G, 1998, NEPHRON, V80, P166, DOI 10.1159/000045161
   Pecoits-Filho R, 2002, NEPHROL DIAL TRANSPL, V17, P1684, DOI 10.1093/ndt/17.9.1684
   Prakash M, 2010, Indian J Nephrol, V20, P9, DOI 10.4103/0971-4065.62088
   Sakuma N, 2002, J NUTR SCI VITAMINOL, V48, P278, DOI 10.3177/jnsv.48.278
   Saland JM, 2007, PEDIATR NEPHROL, V22, P1095, DOI 10.1007/s00467-007-0467-5
   Saland JM, 2010, KIDNEY INT, V78, P1154, DOI 10.1038/ki.2010.311
   Trevino-Becerra Alejandro, 2009, Cir Cir, V77, P411
   Zimmet P, 2007, LANCET, V369, P2059, DOI 10.1016/S0140-6736(07)60958-1
NR 35
TC 4
Z9 4
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0188-4409
EI 1873-5487
J9 ARCH MED RES
JI Arch. Med. Res.
PD NOV
PY 2013
VL 44
IS 8
SI SI
BP 645
EP 649
DI 10.1016/j.arcmed.2013.10.014
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 281DM
UT WOS:000329080100012
PM 24211756
DA 2025-06-11
ER

PT J
AU Palmieri, VO
   Coppola, B
   Grattagliano, I
   Casieri, V
   Cardinale, G
   Portincasa, P
   Palasciano, G
   Di Serio, F
AF Palmieri, Vincenzo O.
   Coppola, Brigida
   Grattagliano, Ignazio
   Casieri, Valentina
   Cardinale, Giovanna
   Portincasa, Piero
   Palasciano, Giuseppe
   Di Serio, Francesca
TI Oxidized LDL Receptor 1 gene polymorphism in patients with Metabolic
   Syndrome
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE Insulin resistance; LOX-1 polymorphism; Metabolic Syndrome;
   microalbuminuria; Thiobarbituric acid; Thioredoxin
ID LOW-DENSITY-LIPOPROTEIN; ACUTE MYOCARDIAL-INFARCTION;
   CORONARY-ARTERY-DISEASE; LECTIN-LIKE; LOX-1 EXPRESSION; OLR1 GENE;
   MONOCYTE ADHESION; ENDOTHELIAL-CELLS; ATHEROSCLEROSIS; RISK
AB Aims The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), encoded by the OLR1 gene, has been implicated in the pathogenesis of atherosclerosis. We therefore evaluated the genotyping of OLR1 gene in a sample of 55 patients with
   Metabolic Syndrome, a clinical condition characterized by a high cardiovascular risk. Methods and Patients The genotyping of the LOX-1 was performed by polymerase chain reaction (PCR) analysis of the IVS4-14 A > G OLR1 polymorphism embedded within the OLR1 Linkage Disequilibrium block. Patients were assessed for routine serum parameters, microalbuminuria, insulin resistance (HOMA) and oxidative stress (thiobarbituric acid reactive substances, TBARs and thioredoxin).
   Results The allele or genotype distribution of the OLR1 IVS4-14 A > G was not statistically different between MS and controls subjects. A positive association was found between IVS4-14 GG genotype, microalbuminuria and fasting glycaemia as well as a higher frequency of type 2 diabetes, elevated microalbuminuria, fasting serum glucose and HOMA index in the same subjects. Thioredoxin values were higher in patients with MS but did not differ in relation to OLR1 IVS4-14 A > G genotype. The TBARs/Cholesterol ratio was higher in MS both in IVS4-14 GG and in IVS4-14 AG.
   Conclusion IVS4-14 GG genotype seems to be related to glucose metabolism disturbance, elevated insulin level and lipid peroxidation in patients with MS.
C1 [Palmieri, Vincenzo O.; Grattagliano, Ignazio; Cardinale, Giovanna; Portincasa, Piero; Palasciano, Giuseppe] Univ Bari, Clin Med A Murri, Dept Biomed Sci & Human Oncol, Bari, Italy.
   [Coppola, Brigida; Casieri, Valentina; Di Serio, Francesca] Policlin Univ Hosp, Dept Clin Pathol 1, Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro
RP Palmieri, VO (corresponding author), Univ Bari Policlin, Clin Med A Murri, Dept Biomed Sci & Human Oncol, I-70124 Bari, Italy.
EM v.o.palmieri@gmail.com
RI portincasa, piero/J-7245-2018
OI Palasciano, Giuseppe/0000-0002-0396-488X; palmieri, vincenzo
   ostilio/0000-0002-7649-6028; portincasa, piero/0000-0001-5359-1471
CR Aoyama T, 1999, BIOCHEM J, V339, P177, DOI 10.1042/0264-6021:3390177
   Chen MJ, 2002, PHARMACOL THERAPEUT, V95, P89, DOI 10.1016/S0163-7258(02)00236-X
   Chen MY, 2000, ARTERIOSCL THROM VAS, V20, P1107, DOI 10.1161/01.ATV.20.4.1107
   Chen MY, 2001, BIOCHEM BIOPH RES CO, V287, P962, DOI 10.1006/bbrc.2001.5674
   Chen Q, 2003, CIRCULATION, V107, P3146, DOI 10.1161/01.CIR.0000074207.85796.36
   Chui PC, 2005, J CLIN INVEST, V115, P2244, DOI 10.1172/JCI24130
   Grattagliano I, 2008, J NUTR BIOCHEM, V19, P491, DOI 10.1016/j.jnutbio.2007.06.011
   Grattagliano I, 2007, HEPATOLOGY, V45, P331, DOI 10.1002/hep.21519
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Kita T, 1999, DIABETES RES CLIN PR, V45, P123, DOI 10.1016/S0168-8227(99)00041-8
   Kume N, 1998, CIRC RES, V83, P322, DOI 10.1161/01.RES.83.3.322
   Li DY, 2002, AM J PHYSIOL-HEART C, V283, pH1795, DOI 10.1152/ajpheart.00382.2002
   Li L, 2004, CIRC RES, V94, P892, DOI 10.1161/01.RES.0000124920.09738.26
   Li L, 2003, DIABETES, V52, P1843, DOI 10.2337/diabetes.52.7.1843
   Maione A, 2007, J NEPHROL, V20, P646
   Mango R, 2005, CIRC RES, V97, P152, DOI 10.1161/01.RES.0000174563.62625.8e
   Mango R, 2003, J MED GENET, V40, P933, DOI 10.1136/jmg.40.12.933
   McNeill AM, 2005, DIABETES CARE, V28, P385, DOI 10.2337/diacare.28.2.385
   Mehta JL, 2006, CARDIOVASC RES, V69, P36, DOI 10.1016/j.cardiores.2005.09.006
   Murphy JE, 2005, ATHEROSCLEROSIS, V182, P1, DOI 10.1016/j.atherosclerosis.2005.03.036
   Musso G, 2011, AM J CLIN NUTR, V94, P1033, DOI 10.3945/ajcn.111.015610
   Nagase M, 1997, BIOCHEM BIOPH RES CO, V237, P496, DOI 10.1006/bbrc.1997.7176
   National Institutes of Health (NIH), 2001, NIH PUBL
   Palmieri VO, 2006, J NUTR, V136, P3022, DOI 10.1093/jn/136.12.3022
   Renier G, 2007, CURR DIABETES REV, V3, P103, DOI 10.2174/157339907780598225
   Renier Genevieve, 2008, Cardiovascular & Hematological Disorders - Drug Targets, V8, P203, DOI 10.2174/187152908785849107
   Sawamura T, 1997, NATURE, V386, P73, DOI 10.1038/386073a0
   Sentinelli F, 2006, NUTR METAB CARDIOVAS, V16, P345, DOI 10.1016/j.numecd.2005.06.002
   Simera I, 2010, EUR J CLIN INVEST, V40, P35, DOI 10.1111/j.1365-2362.2009.02234.x
   Tan KCB, 2008, J LIPID RES, V49, P1438, DOI 10.1194/jlr.M700551-JLR200
   Trabetti E, 2006, EUR J HUM GENET, V14, P127, DOI 10.1038/sj.ejhg.5201513
   Vecchione Lucia, 2007, Recent Pat Cardiovasc Drug Discov, V2, P147
   Vietri MT, 2010, GENET TEST MOL BIOMA, V14, P9, DOI 10.1089/gtmb.2009.0101
NR 33
TC 14
Z9 15
U1 0
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD JAN
PY 2013
VL 43
IS 1
BP 41
EP 48
DI 10.1111/eci.12013
PG 8
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 074MK
UT WOS:000313816400006
PM 23134583
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Yesilova, Y
   Turan, E
   Ucmak, D
   Selek, S
   Yavuz, BH
   Tanrikulu, O
AF Yesilova, Yavuz
   Turan, Enver
   Ucmak, Derya
   Selek, Sahabettin
   Yavuz, Brahim Halil
   Tanrikulu, Osman
TI Reduced serum paraoxonase-1 levels in vitiligo: further evidence of
   oxidative stress
SO REDOX REPORT
LA English
DT Article
DE Vitiligo; Paraoxonase 1; Oxidative stress index
ID GLUTATHIONE-PEROXIDASE ACTIVITIES; TOTAL ANTIOXIDANT RESPONSE;
   QUALITY-OF-LIFE; LIPID-PEROXIDATION; ACTIVE VITILIGO;
   SUPEROXIDE-DISMUTASE; METABOLIC SYNDROME; BEHCETS-DISEASE; SELENIUM
   LEVELS; TISSUE-LEVEL
AB Vitiligo is a common disorder that results in depigmented areas of the skin. The pathogenesis of the disease remains unclear, but oxidative stress is one suggested cause. Oxidative stress may be induced by increasing the generation of reactive oxygen species and other free radicals. The generation of reactive oxygen species is known to be associated with a decrease in antioxidant levels. This study examined oxidative stress index in active lesions of generalized vitiligo patients. We analysed serum levels of paraoxonase 1, arylesterase, catalase, ceruloplasmin, total antioxidant capacity, and oxidative stress index in patients with active lesions of generalized vitiligo, as well as in matched, healthy controls. Serum oxidants and oxidative stress indexes were higher, and serum antioxidants were lower, in vitiligo patients compared with healthy controls. Our findings suggest that oxidative stress may play an important role in the pathogenesis of vitiligo. Paraoxonase 1 can be used as an indicator in determining oxidative stress existent in the pathogenesis of vitiligo diseases.
C1 [Yesilova, Yavuz; Turan, Enver; Tanrikulu, Osman] Harran Univ, Dept Dermatol, Fac Med, TR-63200 Sanliurfa, Turkey.
   [Ucmak, Derya] Dicle Univ, Sch Med, Dept Dermatol, Diyarbakir, Turkey.
   [Selek, Sahabettin] Harran Univ, Dept Biochem, Fac Med, TR-63200 Sanliurfa, Turkey.
   [Yavuz, Brahim Halil] Sivas Numune Hosp, Dermatol Clin, Sivas, Turkey.
C3 Harran University; Dicle University; Harran University; Sivas Numune
   Hospital
RP Yesilova, Y (corresponding author), Harran Univ, Dept Dermatol, Fac Med, TR-63200 Sanliurfa, Turkey.
EM yavuzyesilova@gmail.com
RI Turan, Eylem/IQW-5912-2023; Yeşilova, Abdullah/AAX-2682-2020; SELEK,
   Sahabettin/N-9323-2019
OI SELEK, Sahabettin/0000-0003-1235-3957; yavuz, ibrahim
   halil/0000-0003-0819-2871
CR Agrawal D, 2004, PIGM CELL RES, V17, P289, DOI 10.1111/j.1600-0749.2004.00149.x
   Aksoy SN, 2009, EUR J DERMATOL, V19, P576, DOI 10.1684/ejd.2009.0793
   Alikhan A, 2011, J AM ACAD DERMATOL, V65, P473, DOI 10.1016/j.jaad.2010.11.061
   Alp R, 2010, EUR REV MED PHARMACO, V14, P877
   Arican O, 2008, ACTA DERMATOVEN ALP, V17, P12
   Beazley WD, 1999, BRIT J DERMATOL, V141, P301
   Boisseau-Garsaud AM, 2002, INT J DERMATOL, V41, P640, DOI 10.1046/j.1365-4362.2002.01472.x
   Briganti S, 2003, J EUR ACAD DERMATOL, V17, P663, DOI 10.1046/j.1468-3083.2003.00751.x
   Cakmak A, 2009, CLIN INVEST MED, V32, pE327, DOI 10.25011/cim.v32i5.6920
   Chakraborty DP, 1996, PIGM CELL RES, V9, P107, DOI 10.1111/j.1600-0749.1996.tb00098.x
   Cheng YP, 2012, PHOTODERMATOL PHOTO, V28, P6, DOI 10.1111/j.1600-0781.2011.00628.x
   Costa LG, 2005, BIOCHEM PHARMACOL, V69, P541, DOI 10.1016/j.bcp.2004.08.027
   Dammak I, 2009, INT J DERMATOL, V48, P476, DOI 10.1111/j.1365-4632.2009.03998.x
   Dell'Anna ML, 2003, PIGM CELL RES, V16, P553, DOI 10.1034/j.1600-0749.2003.00087.x
   DelmasBeauvieux MC, 1996, AM J CLIN NUTR, V64, P101, DOI 10.1093/ajcn/64.1.101
   Erel O, 2004, CLIN BIOCHEM, V37, P112, DOI 10.1016/j.clinbiochem.2003.10.014
   Erel O, 1998, CLIN CHEM, V44, P2313
   Erel O, 2005, CLIN BIOCHEM, V38, P1103, DOI 10.1016/j.clinbiochem.2005.08.008
   Ferretti G, 2012, BRIT J DERMATOL, V166, P204, DOI 10.1111/j.1365-2133.2011.10539.x
   Glassman SJ, 2011, CLIN SCI, V120, P99, DOI 10.1042/CS20090603
   Hann SK, 2000, VITILIGO, P137, DOI 10.1002/9780470760116.ch17
   Hasse S, 2004, J INVEST DERMATOL, V122, P307, DOI 10.1046/j.0022-202X.2004.22230.x
   Hazneci E, 2005, INT J DERMATOL, V44, P636, DOI 10.1111/j.1365-4632.2004.02027.x
   Homan MWL, 2009, J AM ACAD DERMATOL, V61, P411, DOI 10.1016/j.jaad.2009.03.022
   Ines D, 2006, ARCH DERMATOL RES, V298, P147, DOI 10.1007/s00403-006-0680-2
   Isik A, 2007, TOHOKU J EXP MED, V212, P133, DOI 10.1620/tjem.212.133
   Jain A, 2011, INDIAN J CLIN BIOCHE, V26, P78, DOI 10.1007/s12291-010-0045-7
   Jalel Akrem, 2009, Indian J Dermatol, V54, P13, DOI 10.4103/0019-5154.48978
   Karakucuk S, 2004, BRIT J OPHTHALMOL, V88, P1256, DOI 10.1136/bjo.2004.043398
   Karsen H, 2011, AFR HEALTH SCI, V11, pS14
   Khan R, 2009, ARCH DERMATOL RES, V301, P731, DOI 10.1007/s00403-009-0964-4
   Passi S, 1998, PIGM CELL RES, V11, P81, DOI 10.1111/j.1600-0749.1998.tb00714.x
   Schallreuter KU, 1999, J INVEST DERM SYMP P, V4, P91, DOI 10.1038/sj.jidsp.5640189
   Sentí M, 2003, J CLIN ENDOCR METAB, V88, P5422, DOI 10.1210/jc.2003-030648
   Shah H, 2008, INDIAN J DERMATOL VE, V74, DOI 10.4103/0378-6323.45144
   Spencer JD, 2007, J INVEST DERMATOL, V127, P411, DOI 10.1038/sj.jid.5700538
   Sravani PV, 2009, INDIAN J DERMATOL VE, V75, P268, DOI 10.4103/0378-6323.48427
   Tsiskarishvili N V, 2006, Georgian Med News, P80
   Usta M, 2011, J CLIN LAB ANAL, V25, P289, DOI 10.1002/jcla.20471
   Yildirim M, 2004, J EUR ACAD DERMATOL, V18, P683, DOI 10.1111/j.1468-3083.2004.01080.x
NR 40
TC 13
Z9 13
U1 0
U2 14
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1351-0002
EI 1743-2928
J9 REDOX REP
JI Redox Rep.
PD SEP
PY 2012
VL 17
IS 5
BP 214
EP 218
DI 10.1179/1351000212Y.0000000025
PG 5
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 022PL
UT WOS:000309971800006
PM 23068968
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Malarvizhi, R
   Mani, S
   Sali, VK
   Bhardwaj, M
   Vasanthi, HR
AF R., Malarvizhi
   Mani, Sugumar
   Sali, Veeresh K.
   Bhardwaj, Meenakshi
   Vasanthi, Hannah R.
TI Macrotyloma uniflorum a plant food alleviates the metabolic
   syndrome through modulation of adipokines and PPARs
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE AMPK; brown fat; M; uniflorum; metabolic syndrome; PPAR
ID DIET-INDUCED OBESITY; HORSE GRAM; FATTY-ACID; RAT MODEL; PHYTOCHEMICALS;
   HYPERTENSION; ADIPONECTIN; EXTRACTION; DISEASE; PROTEIN
AB A sedentary lifestyle combined with the intake of high-calorie diet has been the paramount cause of metabolic syndrome (MS) which is now a serious concern of public health worldwide as it involves the coexistence of hypertension, hyperlipidemia, glucose intolerance, and obesity. Hence, identifying a suitable strategy to overcome the worldwide menace of MS is imperative. Macrotyloma uniflorum a lesser known legume is highly nutritious and notable for its ethano-medicinal potential. Herein, the influence of M. uniflorum in high-fat dietinduced metabolic changes in a rodent model of metabolic syndrome was evaluated. Serum levels of glucose, total cholesterol, triglycerides, VLDL-c, and bodyweight were decreased, whereas HDL-c was increased in M. uniflorum-treated MS rats. The protein expression (AMPK-alpha, PPAR-alpha, and PPAR-gamma) and gene expression (leptin, adiponectin, resistin, UCP2, NF-kappa B, and IL-6) results are impressive to highlight that M. uniflorum modulates the pathological conditions of MS and proves to be cardioprotective. Furthermore, the histopathological analysis confirmed the pathological changes and substantiates the influence of M. uniflorum to overcome MS. The HPLC and GC (MS) profiling reveals the presence of an array of polyphenols such as rutin (694.61 mu g/g), catechin (500.12 mu g/g), epicatechin (158.10 mu g/g), gallic acid (17.98 mu g/g), ferulic acid (10.911 mu g/g), daidzein (6.51 mu g/g), and PUFA, respectively, which probably exhibits the therapeutic effect on MS and associated complications by modulating lipid metabolism and adipogenesis.
   Practical applications Metabolic disorders like CVD and diabetes are leading cause of mortality and morbidity worldwide. With emerging issues on adverse effects of modern drugs, the emphasis on "Food is Medicine and Medicine as Food" has taken dramatic dimensions in the healthcare sector. Therefore, nutraceuticals are in great demand in the developed world off late. Legumes, are potent elements in a balanced diet next to cereals. Exploring the medicinal properties of legumes could bring a revolution in public health and nutraceutical industries. This study scientifically validated the phytochemicals in M. uniflorum for its functional potential in the management of Metabolic Syndrome (MS). This study would help the nutraceutical industries to develop functional foods using M. uniflorum seeds to make porridges and soups or nutraceutical supplements with the bioflavonoids isolated from M. uniflorum for the management of metabolic disorders by mitigating hyperlipidemia, oxidative stress, and inflammation.
C1 [R., Malarvizhi; Mani, Sugumar; Sali, Veeresh K.; Bhardwaj, Meenakshi; Vasanthi, Hannah R.] Pondicherry Univ, Sch Life Sci, Dept Biotechnol, Nat Prod Res Lab, Pondicherry, India.
C3 Pondicherry University
RP Vasanthi, HR (corresponding author), Pondicherry Univ, Sch Life Sci, Dept Biotechnol, Pondicherry 605014, India.
EM hrvasanthi@gmail.com
RI VASANTHI, HANNAH/JPA-2689-2023
OI Bhardwaj, Meenakshi/0000-0003-4771-5145; Vasanthi, Hannah
   Rachel/0000-0001-6804-8332
FU DST-FIST grant; UGC-SAP grant; UGC fellowship from Pondicherry
   University
FX The authors acknowledge the DST-FIST and UGC-SAP grants for developing
   infrastructural facilities in the Department of Biotechnology,
   Pondicherry University for executing the present study, and the UGC
   fellowship from Pondicherry University to the first author. The
   histopathological and microphotographs prepared in CIDRF of Mahatma
   Gandhi Medical College and Research Institute, Puducherry are
   acknowledged with a special mention.
CR Aborehab NM, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1203-0
   Ali BH, 2008, FOOD CHEM TOXICOL, V46, P409, DOI 10.1016/j.fct.2007.09.085
   Arita Y, 1999, BIOCHEM BIOPH RES CO, V257, P79, DOI 10.1006/bbrc.1999.0255
   Assifi MM, 2005, AM J PHYSIOL-ENDOC M, V289, pE794, DOI 10.1152/ajpendo.00144.2005
   Bhartiya A, 2015, J ANIM PLANT SCI-PAK, V25, P908
   BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911
   Blüher M, 2015, MOL METAB, V4, P79, DOI 10.1016/j.molmet.2014.12.003
   BRADLEY PP, 1982, J INVEST DERMATOL, V78, P206, DOI 10.1111/1523-1747.ep12506462
   Bruder-Nascimento T, 2015, CLIN SCI, V128, P411, DOI 10.1042/CS20140456
   Chukwumah YC, 2007, J AGR FOOD CHEM, V55, P285, DOI 10.1021/jf062148t
   Cicero AFG, 2016, PHYTOMEDICINE, V23, P1134, DOI 10.1016/j.phymed.2015.11.009
   de Souza BM, 2011, ARQ BRAS ENDOCRINOL, V55, P239, DOI 10.1590/S0004-27302011000400001
   Dhaubhadel S, 2003, PLANT MOL BIOL, V53, P733, DOI 10.1023/B:PLAN.0000023666.30358.ae
   Dobrian AD, 2003, AM J PHYSIOL-RENAL, V285, pF619, DOI 10.1152/ajprenal.00388.2002
   Dobrian AD, 2000, HYPERTENSION, V35, P1009, DOI 10.1161/01.HYP.35.4.1009
   Engin A, 2017, ADV EXP MED BIOL, V960, P1, DOI 10.1007/978-3-319-48382-5_1
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   Gayathri V, 2011, NAT PROD RES, V25, P1110, DOI 10.1080/14786419.2010.541883
   Graf BL, 2010, CURR OPIN INVEST DR, V11, P1107
   GRAHAM TL, 1991, PLANT PHYSIOL, V95, P594, DOI 10.1104/pp.95.2.594
   Gutch Manish, 2015, Indian J Endocrinol Metab, V19, P160, DOI 10.4103/2230-8210.146874
   Harp JB, 2004, CURR OPIN LIPIDOL, V15, P303, DOI 10.1097/00041433-200406000-00010
   Hong EG, 2009, DIABETES, V58, P2525, DOI 10.2337/db08-1261
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kawsar S. M. A., 2010, American Journal of Plant Physiology, V5, P204
   Krauss Ronald M., 1998, American Journal of Medicine, V105, p58S, DOI 10.1016/S0002-9343(98)00213-7
   Lapa C, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-17148-w
   Larsen TM, 2003, INT J OBESITY, V27, P147, DOI 10.1038/sj.ijo.802223
   Li Q, 2016, AM J TRANSL RES, V8, P4160
   Marques C, 2016, ADIPOCYTE, V5, P11, DOI 10.1080/21623945.2015.1061723
   Martin ASG, 2006, AM J CLIN NUTR, V83, p461S, DOI 10.1093/ajcn/83.2.461s
   Meier U, 2004, CLIN CHEM, V50, P1511, DOI 10.1373/clinchem.2004.032482
   Morris JB, 2008, GENET RESOUR CROP EV, V55, P5, DOI 10.1007/s10722-007-9298-2
   Morris JB, 2013, AGRICULTURE-BASEL, V3, P157, DOI 10.3390/agriculture3010157
   Nogueiras R, 2010, ENDOCR DEV, V17, P175, DOI 10.1159/000262538
   Panchal SK, 2010, J BIOMED BIOTECHNOL, V2011, P1
   Panchal SK, 2011, J CARDIOVASC PHARM, V57, P51, DOI [10.1097/FJC.0b013e3181feb90a, 10.1097/FJC.0b013e31821b1379]
   Prakash P, 2011, CARDIOVASC DRUG THER, V25, P285, DOI 10.1007/s10557-011-6312-x
   Prasad SK, 2015, J FOOD SCI TECH MYS, V52, P2489, DOI 10.1007/s13197-014-1312-z
   Ramalingam M, 2020, COMB CHEM HIGH T SCR, V23, P931, DOI 10.2174/1386207323666200127114551
   Rebello CJ, 2014, OBES REV, V15, P392, DOI 10.1111/obr.12144
   Roberts-Toler C, 2015, OBESITY, V23, P1765, DOI 10.1002/oby.21134
   Seigler DS., 1998, PLANT SECONDARY META
   Shimizu I, 2014, J CLIN INVEST, V124, P2099, DOI 10.1172/JCI71643
   Sreerama YN, 2012, FOOD CHEM, V131, P462, DOI 10.1016/j.foodchem.2011.09.008
   Sung YY, 2011, MOL MED REP, V4, P431, DOI 10.3892/mmr.2011.451
   Thirumaran A.S, 2000, Pulses Production Strategies in Tamil Nadu, P129
   TOWBIN H, 1979, P NATL ACAD SCI USA, V76, P4350, DOI 10.1073/pnas.76.9.4350
   Tvrzicka E, 2011, BIOMED PAP, V155, P117, DOI 10.5507/bp.2011.038
   Yu SH, 2016, SCI REP-UK, V6, DOI 10.1038/srep20399
   Yusuf S, 2005, LANCET, V366, P1640, DOI 10.1016/S0140-6736(05)67663-5
   Zuo JC, 2017, CELL PHYSIOL BIOCHEM, V42, P1514, DOI 10.1159/000479268
NR 53
TC 6
Z9 6
U1 2
U2 10
PU WILEY-HINDAWI
PI LONDON
PA ADAM HOUSE, 3RD FL, 1 FITZROY SQ, LONDON, WIT 5HE, ENGLAND
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD FEB
PY 2021
VL 45
IS 2
AR e13595
DI 10.1111/jfbc.13595
EA DEC 2020
PG 14
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA QL9IC
UT WOS:000601091200001
PM 33368458
OA gold
DA 2025-06-11
ER

PT J
AU Kharouf, F
   Gladman, DD
AF Kharouf, Fadi
   Gladman, Dafna D.
TI Advances in the management of psoriatic arthritis in adults
SO BMJ-BRITISH MEDICAL JOURNAL
LA English
DT Review
ID PLACEBO-CONTROLLED TRIAL; BIOLOGIC-NAIVE PATIENTS; DOUBLE-BLIND;
   MONOCLONAL-ANTIBODY; INADEQUATE RESPONSE; DISEASE-ACTIVITY; PHASE-III;
   PERIPHERAL ARTHRITIS; CLINICAL ENTHESITIS; EXERCISE PROGRAM
AB Psoriatic arthritis is an inflammatory arthritis that affects around 30% of patients with psoriasis. The disease spectrum includes peripheral arthritis, enthesitis, tenosynovitis, dactylitis, axial involvement, and skin and nail psoriasis in most patients. In addition to the cutaneous and musculoskeletal manifestations, several comorbidities can complicate the disease course, including cardiovascular disease, diabetes mellitus, metabolic syndrome, gout, anxiety, and depression. The management of patients with psoriatic arthritis begins with a careful assessment of the skin and joints and screening for comorbidities. This review describes the assessment tools and outcome measures used in the evaluation of patients with psoriatic arthritis. It summarizes the approach to therapy, including non-medicinal interventions such as education, lifestyle changes, physiotherapy, and occupational therapy. It discusses the evidence on pharmacologic treatments, including drugs used for symptomatic relief such as non-steroidal anti-inflammatory drugs, and those used to control the disease process; this last group comprises conventional synthetic disease modifying anti-rheumatic drugs (DMARDs), including methotrexate, leflunomide, and sulfasalazine, and biologic and targeted DMARDs, including anti-tumor necrosis factor (TNF alpha), anti-interleukin-17 (IL-17), anti-IL-12/23, and anti-IL-23 agents, as well as Janus kinase (JAK) inhibitors and phosphodiesterase 4 (PDE4) antagonists. Although these drugs are usually tailored to the clinical profile of the patient, biomarkers predictive of response to therapy are needed so that a more personalized approach can be followed.
C1 [Kharouf, Fadi; Gladman, Dafna D.] Univ Toronto, Univ Hlth Network, Toronto Western Hosp, Psoriat Arthrit Program, Toronto, ON, Canada.
   [Kharouf, Fadi; Gladman, Dafna D.] Toronto Western Hosp, Gladman Krembil Psoriat Dis Program, Toronto, ON, Canada.
C3 University of Toronto; University Health Network Toronto; University of
   Toronto; University Health Network Toronto
RP Gladman, DD (corresponding author), Univ Toronto, Univ Hlth Network, Toronto Western Hosp, Psoriat Arthrit Program, Toronto, ON, Canada.; Gladman, DD (corresponding author), Toronto Western Hosp, Gladman Krembil Psoriat Dis Program, Toronto, ON, Canada.
EM dafna.gladman@utoronto.ca
RI Gladman, Dafna/AFM-6487-2022; Kharouf, Fadi/AFT-3432-2022
CR Alharbi S, 2020, SEMIN ARTHRITIS RHEU, V50, P1494, DOI 10.1016/j.semarthrit.2020.01.012
   AlJohani R, 2018, J RHEUMATOL, V45, P213, DOI 10.3899/jrheum.170384
   Antoni C, 2005, ANN RHEUM DIS, V64, P1150, DOI 10.1136/ard.2004.032268
   Araujo EG, 2019, SEMIN ARTHRITIS RHEU, V48, P632, DOI 10.1016/j.semarthrit.2018.05.011
   Baeten D, 2018, ANN RHEUM DIS, V77, P1295, DOI 10.1136/annrheumdis-2018-213328
   Behrens F, 2022, ANN RHEUM DIS, V81, P170, DOI 10.1136/annrheumdis-2022-eular.536
   BLACK RL, 1964, JAMA-J AM MED ASSOC, V189, P743
   Blauvelt A, 2021, BRIT J DERMATOL, V184, P1047, DOI 10.1111/bjd.19509
   Blauvelt A, 2020, BRIT J DERMATOL, V182, P1348, DOI 10.1111/bjd.18851
   Blauvelt A, 2017, J AM ACAD DERMATOL, V76, P405, DOI 10.1016/j.jaad.2016.11.041
   Blauvelt A, 2017, J AM ACAD DERMATOL, V76, P60, DOI 10.1016/j.jaad.2016.08.008
   Bond SJ, 2007, ANN RHEUM DIS, V66, P370, DOI 10.1136/ard.2006.056457
   Brockbank JE, 2005, ANN RHEUM DIS, V64, P188, DOI 10.1136/ard.2003.018184
   Caron B, 2022, EXPERT OPIN DRUG SAF, V21, P223, DOI 10.1080/14740338.2021.1960981
   Caso F, 2020, RHEUMATOL INT, V40, P951, DOI 10.1007/s00296-019-04458-7
   Chandran V, 2008, J RHEUMATOL, V35, P469
   Chandran V, 2013, HUM IMMUNOL, V74, P1333, DOI 10.1016/j.humimm.2013.07.014
   Chandran V, 2009, ARTHRIT RHEUM-ARTHR, V61, P1235, DOI 10.1002/art.24562
   Chimenti MS, 2014, DRUG DEVELOP RES, V75, pS57, DOI 10.1002/ddr.21197
   Coates LC, 2010, ANN RHEUM DIS, V69, P48, DOI 10.1136/ard.2008.102053
   Coates LC, 2022, NAT REV RHEUMATOL, V18, P465, DOI 10.1038/s41584-022-00798-0
   Coates LC, 2018, ARTHRITIS RHEUMATOL, V70, P345, DOI 10.1002/art.40391
   Coates LC, 2015, LANCET, V386, P2489, DOI 10.1016/S0140-6736(15)00347-5
   Colaco K., 2021, Journal of the American Academy of Dermatology, V84, P1302, DOI [10.1016/j.jaad.2020.10.031, DOI 10.1016/J.JAAD.2020.10.031]
   Cozzi F, 2015, JOINT BONE SPINE, V82, P104, DOI 10.1016/j.jbspin.2014.11.002
   Cutolo M, 2016, J RHEUMATOL, V43, P1724, DOI 10.3899/jrheum.151376
   Dal Bello G, 2020, RHEUMATOL THER, V7, P271, DOI 10.1007/s40744-020-00206-7
   Davidson L, 2022, LANCET REG HEALTH-EU, V13, DOI 10.1016/j.lanepe.2021.100266
   Deodhar A, 2020, LANCET, V395, P1115, DOI 10.1016/S0140-6736(20)30265-8
   Deodhar A, 2019, ARTHRITIS RHEUMATOL, V71, P258, DOI 10.1002/art.40728
   Duarte-García A, 2019, J RHEUMATOL, V46, P996, DOI 10.3899/jrheum.181089
   Ducourau E, 2020, RMD OPEN, V6, DOI 10.1136/rmdopen-2019-001047
   Eder L, 2017, J RHEUMATOL, V44, P286, DOI 10.3899/jrheum.160861
   Eder L, 2016, ANN RHEUM DIS, V75, P1680, DOI 10.1136/annrheumdis-2015-207980
   Eder L, 2016, ARTHRITIS RHEUMATOL, V68, P915, DOI 10.1002/art.39494
   Eder L, 2015, ANN RHEUM DIS, V74, P1830, DOI 10.1136/annrheumdis-2014-205267
   Eder L, 2012, ANN RHEUM DIS, V71, P50, DOI 10.1136/ard.2011.155044
   Feld J, 2020, RHEUMATOLOGY, V59, P1340, DOI 10.1093/rheumatology/kez457
   Felson DT, 2014, ARTHRITIS RES THER, V16, DOI 10.1186/ar4428
   FitzGerald O, 2021, NAT REV DIS PRIMERS, V7, DOI 10.1038/s41572-021-00293-y
   GARRETT S, 1994, J RHEUMATOL, V21, P2286
   Gladman D, 2017, NEW ENGL J MED, V377, P1525, DOI 10.1056/NEJMoa1615977
   Gladman DD, 2007, J RHEUMATOL, V34, P1733
   Gladman DD, 2022, TRIALS, V23, DOI 10.1186/s13063-022-06589-y
   Gladman DD, 2011, ANN RHEUM DIS, V70, P2152, DOI 10.1136/ard.2011.150938
   Gladman DD, 2009, DERMATOL THER, V22, P40, DOI 10.1111/j.1529-8019.2008.01215.x
   Gladman DD, 2005, ANN RHEUM DIS, V64, P14, DOI 10.1136/ard.2004.032482
   Gladman DD, 1998, ARTHRITIS RHEUM-US, V41, P1103, DOI 10.1002/1529-0131(199806)41:6<1103::AID-ART18>3.0.CO;2-N
   Gladman DD, 1998, J RHEUMATOL, V25, P730
   Gossec L, 2024, ANN RHEUM DIS, V83, P706, DOI 10.1136/ard-2024-225531
   Hailey LH, 2023, CLIN THER, V45, P841, DOI 10.1016/j.clinthera.2023.05.009
   Haroon M, 2015, ANN RHEUM DIS, V74, P1045, DOI 10.1136/annrheumdis-2013-204858
   Haroon M, 2014, J RHEUMATOL, V41, P1357, DOI 10.3899/jrheum.140021
   Healy PJ, 2008, ARTHRIT RHEUM-ARTHR, V59, P686, DOI 10.1002/art.23568
   Helliwell PS, 2013, ANN RHEUM DIS, V72, P986, DOI 10.1136/annrheumdis-2012-201341
   Helliwell PS, 2005, J RHEUMATOL, V32, P1745
   Iskandar IYK, 2021, BRIT J DERMATOL, V185, P952, DOI 10.1111/bjd.20577
   Jadon DR, 2023, J RHEUMATOL, V50, P438, DOI 10.3899/jrheum.220317
   Kane D, 2003, RHEUMATOLOGY, V42, P1469, DOI 10.1093/rheumatology/keg445
   Karmacharya P, 2021, BEST PRACT RES CL RH, V35, DOI 10.1016/j.berh.2021.101692
   Kavanaugh A, 2014, ANN RHEUM DIS, V73, P1020, DOI 10.1136/annrheumdis-2013-205056
   Kavanaugh A, 2009, ARTHRITIS RHEUM-US, V60, P976, DOI 10.1002/art.24403
   Khan M, 2003, J RHEUMATOL, V30, P1022
   Kingsley GH, 2012, RHEUMATOLOGY, V51, P1368, DOI 10.1093/rheumatology/kes001
   Klingberg E, 2019, ARTHRITIS RES THER, V21, DOI 10.1186/s13075-019-1810-5
   Kristensen LE, 2022, ANN RHEUM DIS, V81, P225, DOI 10.1136/annrheumdis-2021-221019
   Kunchok A, 2020, JAMA NEUROL, V77, P937, DOI 10.1001/jamaneurol.2020.1162
   Lee MP, 2019, JAMA DERMATOL, V155, P700, DOI 10.1001/jamadermatol.2019.0001
   Leung YY, 2023, J RHEUMATOL, V50, P119, DOI 10.3899/jrheum.220315
   Lindström U, 2023, RMD OPEN, V9, DOI 10.1136/rmdopen-2022-002883
   Mahil SK, 2019, BRIT J DERMATOL, V181, P946, DOI 10.1111/bjd.17741
   Maksymowych WP, 2009, ANN RHEUM DIS, V68, P948, DOI 10.1136/ard.2007.084244
   McDonough E, 2014, J RHEUMATOL, V41, P887, DOI 10.3899/jrheum.130797
   McInnes IB, 2023, LANCET, V401, P25, DOI 10.1016/S0140-6736(22)02302-9
   McInnes IB, 2021, NEW ENGL J MED, V384, P1227, DOI 10.1056/NEJMoa2022516
   McInnes IB, 2020, LANCET, V395, P1496, DOI 10.1016/S0140-6736(20)30564-X
   McInnes IB, 2015, LANCET, V386, P1137, DOI 10.1016/S0140-6736(15)61134-5
   McInnes IB, 2013, LANCET, V382, P780, DOI 10.1016/S0140-6736(13)60594-2
   Mease P, 2017, NEW ENGL J MED, V377, P1537, DOI 10.1056/NEJMoa1615975
   Mease PJ, 2014, ANN RHEUM DIS, V73, P48, DOI 10.1136/annrheumdis-2013-203696
   Mease P, 2023, ARTHRITIS RHEUMATOL, V75, P1370, DOI 10.1002/art.42519
   Mease Philip J, 2021, Ann Rheum Dis, V80, P312, DOI [10.1136/annrheumdis-2020-218870, 10.1136/annrheumdis-2019-216761]
   Mease P, 2018, ANN RHEUM DIS, V77, P890, DOI 10.1136/annrheumdis-2017-212687
   Mease P, 2013, BULL HOSP JT DIS, V71, pS41
   Mease PJ, 2024, RMD OPEN, V10, DOI 10.1136/rmdopen-2023-003423
   Mease PJ, 2022, ANN RHEUM DIS, V81, P815, DOI 10.1136/annrheumdis-2021-221664
   Mease PJ, 2021, ANN RHEUM DIS, V80, P185, DOI 10.1136/annrheumdis-2019-216835
   Mease PJ, 2021, ANN RHEUM DIS, V80, P1147, DOI 10.1136/annrheumdis-2020-219014
   Mease PJ, 2020, LANCET, V395, P1126, DOI 10.1016/S0140-6736(20)30263-4
   Mease PJ, 2017, ANN RHEUM DIS, V76, P79, DOI 10.1136/annrheumdis-2016-209709
   Mease PJ, 2004, ARTHRITIS RHEUM-US, V50, P2264, DOI 10.1002/art.20335
   Mease PJ, 2005, ARTHRITIS RHEUM-US, V52, P3279, DOI 10.1002/art.21306
   Merola JF, 2023, LANCET, V401, P38, DOI 10.1016/S0140-6736(22)02303-0
   Muftin Z, 2022, BRIT J DERMATOL, V186, P955, DOI 10.1111/bjd.21020
   Mumtaz A, 2011, ANN RHEUM DIS, V70, P272, DOI 10.1136/ard.2010.129379
   Nash P, 2018, ARTHRITIS RES THER, V20, DOI 10.1186/s13075-018-1551-x
   Nash P, 2017, LANCET, V389, P2317, DOI 10.1016/S0140-6736(17)31429-0
   Ocampo V, 2023, REV COLOMB REUMATOL, V30, pS8, DOI [10.1016/j.rcreu.2022.12.002, DOI 10.1016/J.RCREU.2022.12.002]
   Ogdie A, 2015, RHEUM DIS CLIN N AM, V41, P545, DOI 10.1016/j.rdc.2015.07.001
   Olivieri I, 2009, J RHEUMATOL, V36, P28, DOI 10.3899/jrheum.090218
   Orbai AM, 2017, ANN RHEUM DIS, V76, DOI 10.1136/annrheumdis-2016-210242
   Östör A, 2022, ANN RHEUM DIS, V81, P351, DOI 10.1136/annrheumdis-2021-221048
   Pakchotanon R, 2020, J RHEUMATOL, V47, P847, DOI 10.3899/jrheum.181312
   Poddubnyy D, 2021, SEMIN ARTHRITIS RHEU, V51, P880, DOI 10.1016/j.semarthrit.2021.06.006
   Poizeau F, 2020, JAMA DERMATOL, V156, P1208, DOI 10.1001/jamadermatol.2020.2977
   Polachek A, 2017, ARTHRIT CARE RES, V69, P1685, DOI 10.1002/acr.23174
   Polachek A, 2017, ARTHRIT CARE RES, V69, P67, DOI 10.1002/acr.22926
   Proft F, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2021-048647
   Reich K, 2017, BRIT J DERMATOL, V177, P1014, DOI 10.1111/bjd.15666
   Reich K, 2022, DERMATOL PRACT CONCE, V12, DOI 10.5826/dpc.1202a104
   Reich K, 2021, LANCET, V397, P487, DOI 10.1016/S0140-6736(21)00125-2
   Reich K, 2019, LANCET, V394, P831, DOI 10.1016/S0140-6736(19)31773-8
   Reich K, 2019, LANCET, V394, P576, DOI 10.1016/S0140-6736(19)30952-3
   Reich K, 2017, J AM ACAD DERMATOL, V76, P418, DOI 10.1016/j.jaad.2016.11.042
   Ritchlin CT, 2009, ANN RHEUM DIS, V68, P1387, DOI 10.1136/ard.2008.094946
   Ritchlin C, 2014, ANN RHEUM DIS, V73, P990, DOI 10.1136/annrheumdis-2013-204655
   Roberts JA, 2020, CURR RHEUMATOL REP, V22, DOI 10.1007/s11926-020-00956-x
   Roger-Silva D, 2018, CLIN RHEUMATOL, V37, P389, DOI 10.1007/s10067-017-3917-x
   Schett G, 2022, NAT REV RHEUMATOL, V18, P311, DOI 10.1038/s41584-022-00776-6
   Sibilia J, 2024, JOINT BONE SPINE, V91, DOI 10.1016/j.jbspin.2023.105645
   Singh JA, 2019, ARTHRITIS RHEUMATOL, V71, P5, DOI 10.1002/art.40726
   Smolen JS, 2018, ANN RHEUM DIS, V77, P472, DOI [10.1136/annrheumdis-2017-211734corr1, 10.1136/annrheumdis-2017-211734]
   Sterry W, 2010, BMJ-BRIT MED J, V340, DOI 10.1136/bmj.c147
   Targan SR, 2016, AM J GASTROENTEROL, V111, P1599, DOI 10.1038/ajg.2016.298
   Taylor W, 2006, ARTHRITIS RHEUM, V54, P2665, DOI 10.1002/art.21972
   Thaçi D, 2015, J AM ACAD DERMATOL, V73, P400, DOI 10.1016/j.jaad.2015.05.013
   Theander E, 2014, ANN RHEUM DIS, V73, P407, DOI 10.1136/annrheumdis-2012-201972
   Tillett W, 2017, RHEUMATOLOGY, V56, P2109, DOI 10.1093/rheumatology/kex323
   Tillett W, 2013, ANN RHEUM DIS, V72, P1358, DOI 10.1136/annrheumdis-2012-202608
   Toledano E, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-48723-z
   van der Heijde D, 2009, ANN RHEUM DIS, V68, P1811, DOI 10.1136/ard.2008.100826
   Warren RB, 2021, NEW ENGL J MED, V385, P130, DOI 10.1056/NEJMoa2102388
   Warren RB, 2021, BRIT J DERMATOL, V184, P50, DOI 10.1111/bjd.19341
   WILLKENS RF, 1984, ARTHRITIS RHEUM-US, V27, P376, DOI 10.1002/art.1780270403
   Wright V, 1976, SERONEGATIVE POLYART, P488
   Wu SW, 2015, J RHEUMATOL, V42, P835, DOI 10.3899/jrheum.140808
   Ytterberg SR, 2022, NEW ENGL J MED, V386, P316, DOI [10.1056/NEJMoa2109927, 10.1056/NEJMc2202778]
   Zhang Z, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2016-012567
NR 138
TC 3
Z9 3
U1 3
U2 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0959-535X
EI 1756-1833
J9 BMJ-BRIT MED J
JI BMJ-British Medical Journal
PD NOV 21
PY 2024
VL 387
AR e081860
DI 10.1136/bmj-2024-081860
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA N7N6Q
UT WOS:001366163200010
PM 39572047
OA Bronze
DA 2025-06-11
ER

PT J
AU Bashir, A
   Duseja, A
   De, AR
   Mehta, M
   Tiwari, P
AF Bashir, Aamir
   Duseja, Ajay
   De, Arka
   Mehta, Manu
   Tiwari, Pramil
TI Non-alcoholic fatty liver disease development: A multifactorial
   pathogenic phenomena
SO LIVER RESEARCH
LA English
DT Review
DE Metabolic syndrome (MS); Non-alcoholic fatty liver disease (NAFLD);
   Non-alcoholic steatohepatitis (NASH); Fatty liver; Steatohepatitis;
   Insulin resistance (IR); Lysosomal acid lipase (LAL)
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; GUT
   MICROBIOME; POSITION PAPER; NAFLD; NASH; ASSOCIATION; ADIPOKINES;
   PROGRESSION
AB Non-alcoholic fatty liver disease (NAFLD), characterized by the accumulation of excessive intrahepatic fat, is a leading metabolic disorder also considered as the hepatic manifestation of metabolic syndrome (MS). Though more commonly observed in obese individuals and those with metabolic risk factors, it also develops in a considerable number of non-obese individuals as well as participants without having any component of MS. The basic mechanism involved in the development of fatty liver is the imbalance between lipid uptake, synthesis, and metabolism in the liver, normally controlled by several mechanisms to maintain lipid homeostasis. As a complex progressive liver disorder, the NAFLD pathogenesis is multifactorial, and several new pathogenic phenomena were discovered over time. The available liter-ature suggests the role of both genetic and environmental factors and associated metabolic factors; however, the mechanism of progression is not completely understood. In this review, we discuss different pathogenic mechanisms and their interplay to provide an elaborate idea regarding NAFLD development and progression. Better understanding of pathogenic mechanisms will be useful in finding new treatment for patients with NAFLD.& COPY; 2022 The Third Affiliated Hospital of Sun Yat-sen University. Publishing services by Elsevier B. V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Bashir, Aamir; Tiwari, Pramil] Natl Inst Pharmaceut Educ & Res, Dept Pharm Practice, Mohali, Punjab, India.
   [Duseja, Ajay; De, Arka; Mehta, Manu] Post Grad Inst Med Educ & Res, Dept Hepatol, Chandigarh, India.
C3 National Institute of Pharmaceutical Education & Research, S.A.S. Nagar
   (Mohali); Post Graduate Institute of Medical Education & Research
   (PGIMER), Chandigarh
RP Tiwari, P (corresponding author), Natl Inst Pharmaceut Educ & Res, Dept Pharm Practice, Mohali, Punjab, India.
EM ptiwari@niper.ac.in
RI ; De, Arka/AAK-7972-2021
OI Tiwari, Pramil/0000-0003-0442-7880; De, Arka/0000-0002-8567-1676
CR Abul-Husn NS, 2018, NEW ENGL J MED, V378, P1096, DOI 10.1056/NEJMoa1712191
   Adolph TE, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18081649
   Aguisanda Francis, 2017, Curr Chem Genom Transl Med, V11, P1, DOI 10.2174/2213988501711010001
   Anstee QM, 2019, NAT REV GASTRO HEPAT, V16, P411, DOI 10.1038/s41575-019-0145-7
   Anwar H, 2021, BIOMED RES INT, V2021, DOI 10.1155/2021/5575245
   Arab JP, 2017, HEPATOLOGY, V65, P350, DOI 10.1002/hep.28709
   Baratta F, 2019, WORLD J GASTROENTERO, V25, P4172, DOI 10.3748/wjg.v25.i30.4172
   Bashir Aamir, 2021, Ther Adv Rare Dis, V2, p26330040211026928, DOI 10.1177/26330040211026928
   Bashir A, 2022, J CLIN EXP HEPATOL, V12, P1535, DOI 10.1016/j.jceh.2022.04.011
   Bessone F, 2019, CELL MOL LIFE SCI, V76, P99, DOI 10.1007/s00018-018-2947-0
   Bibbò S, 2018, MEDIAT INFLAMM, V2018, DOI 10.1155/2018/9321643
   Blanchet E, 2012, FASEB J, V26, P40, DOI 10.1096/fj.11-186841
   Block RC, 2017, ATHEROSCLEROSIS, V262, P140, DOI 10.1016/j.atherosclerosis.2017.04.018
   Boutari C, 2018, ENDOCRINOL METAB, V33, P33, DOI 10.3803/EnM.2018.33.1.33
   Bovi APD, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.595371
   Buzzetti E, 2016, METABOLISM, V65, P1038, DOI 10.1016/j.metabol.2015.12.012
   Cariou B, 2021, DIABETES OBES METAB, V23, P1069, DOI 10.1111/dom.14322
   Carter A, 2019, J HEPATOL, V70, P142, DOI 10.1016/j.jhep.2018.09.028
   Catrysse L, 2017, TRENDS CELL BIOL, V27, P417, DOI 10.1016/j.tcb.2017.01.006
   Caturano A, 2021, PROCESSES, V9, DOI 10.3390/pr9010135
   Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI 10.1002/hep.29367
   Chen F, 2020, HEPATOLOGY, V71, P1213, DOI 10.1002/hep.30908
   Chen HT, 2020, WORLD J GASTROENTERO, V26, P1901, DOI 10.3748/wjg.v26.i16.1901
   Chen ZG, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0572-9
   Choudhary NS, 2021, TRANSL GASTROENT HEP, V6, DOI 10.21037/tgh.2019.09.06
   Claudel T, 2002, J CLIN INVEST, V109, P961
   Corbin KD, 2012, CURR OPIN GASTROEN, V28, P159, DOI 10.1097/MOG.0b013e32834e7b4b
   Cordeiro A, 2013, J ENDOCRINOL, V216, pR47, DOI 10.1530/JOE-12-0542
   Cyphert HA, 2012, J BIOL CHEM, V287, P25123, DOI 10.1074/jbc.M112.375907
   De Arka, 2021, Clin Liver Dis (Hoboken), V18, P158, DOI 10.1002/cld.1141
   De A, 2020, J CLIN EXP HEPATOL, V10, P255, DOI 10.1016/j.jceh.2019.09.005
   Ding LL, 2016, HEPATOLOGY, V64, P760, DOI 10.1002/hep.28689
   Dornas W, 2020, AM J PHYSIOL-GASTR L, V319, pG400, DOI 10.1152/ajpgi.00121.2020
   Duarte SMB, 2018, NUTR METAB CARDIOVAS, V28, P369, DOI 10.1016/j.numecd.2017.10.014
   Duseja A, 2013, HEPATOL INT, V7, pS755, DOI 10.1007/s12072-013-9480-x
   Duseja A, 2015, J CLIN EXP HEPATOL, V5, P51, DOI 10.1016/j.jceh.2015.02.006
   Duseja A, 2014, CLIN LIVER DIS, V18, P59, DOI 10.1016/j.cld.2013.09.002
   Eliades M, 2013, ALIMENT PHARM THER, V38, P246, DOI 10.1111/apt.12377
   Eslam Mohammed, 2020, Clin Liver Dis (Hoboken), V16, P240, DOI 10.1002/cld.930
   Eslam M, 2018, J HEPATOL, V68, P268, DOI 10.1016/j.jhep.2017.09.003
   Fasano T, 2012, MOL GENET METAB, V105, P450, DOI 10.1016/j.ymgme.2011.12.008
   Fei N, 2020, MBIO, V11, DOI 10.1128/mBio.03263-19
   Ferrandino G, 2017, P NATL ACAD SCI USA, V114, pE9172, DOI 10.1073/pnas.1707797114
   Ferri F, 2020, CLIN TRANSL GASTROEN, V11, DOI 10.14309/ctg.0000000000000116
   Fialho A, 2016, J GASTROINTEST LIVER, V25, P159, DOI 10.15403/jgld.2014.1121.252.iwg
   Fiorucci S, 2020, EXPERT OPIN INV DRUG, V29, P623, DOI 10.1080/13543784.2020.1763302
   Francque S, 2021, NAT REV GASTRO HEPAT, V18, P24, DOI 10.1038/s41575-020-00366-5
   Geng YN, 2021, HEPATOL INT, V15, P21, DOI 10.1007/s12072-020-10121-2
   Godoy-Matos AF, 2020, DIABETOL METAB SYNDR, V12, DOI 10.1186/s13098-020-00570-y
   Gomaraschi M, 2019, BBA-MOL CELL BIOL L, V1864, DOI 10.1016/j.bbalip.2019.158523
   Grohmann M, 2018, CELL, V175, P1289, DOI 10.1016/j.cell.2018.09.053
   Gruneau L, 2023, CLIN GASTROENTEROL H, V21, P283, DOI 10.1016/j.cgh.2021.10.040
   Hyun J, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21218138
   Jadhav K, 2018, MOL METAB, V9, P131, DOI 10.1016/j.molmet.2018.01.005
   Janeiro MH, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101398
   Jonas W, 2020, MOL METAB, V50, DOI 10.1016/j.molmet.2020.101111
   Kar K, 2017, J CLIN DIAGN RES, V11, pBC7, DOI 10.7860/JCDR/2017/26666.10345
   Karamfilova V, 2019, J GASTROINTEST LIVER, V28, P433, DOI 10.15403/jgld-506
   Kim SG, 2016, ENDOCRINOL METAB, V31, P500, DOI 10.3803/EnM.2016.31.4.500
   Kleiner DE, 2019, JAMA NETW OPEN, V2, DOI 10.1001/jamanetworkopen.2019.12565
   Kozlitina J, 2014, NAT GENET, V46, P352, DOI 10.1038/ng.2901
   Kuchay MS, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9101346
   Kumar S, 2021, ADV DRUG DELIVER REV, V176, DOI 10.1016/j.addr.2021.113869
   Lau JKC, 2017, J PATHOL, V241, P36, DOI 10.1002/path.4829
   Lee J, 2017, MOL ASPECTS MED, V54, P78, DOI 10.1016/j.mam.2016.11.008
   Liu L, 2017, INT J ENDOCRINOL, V2017, DOI 10.1155/2017/5753039
   Lonardo A, 2017, WORLD J GASTROENTERO, V23, P6571, DOI 10.3748/wjg.v23.i36.6571
   Lonardo A, 2017, DIGEST LIVER DIS, V49, P471, DOI 10.1016/j.dld.2017.01.147
   Lopresti MW, 2021, J LIPID RES, V62, DOI 10.1016/j.jlr.2021.100133
   Luan JY, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.02201
   Mancina RM, 2016, GASTROENTEROLOGY, V150, P1219, DOI 10.1053/j.gastro.2016.01.032
   Mann JP, 2017, EXPERT REV GASTROENT, V11, P371, DOI 10.1080/17474124.2017.1291340
   Mantovani A, 2021, GUT, V70, P962, DOI 10.1136/gutjnl-2020-322572
   Marchisello S, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20081948
   Mato JM, 2019, WORLD J GASTROENTERO, V25, P3009, DOI 10.3748/wjg.v25.i24.3009
   Mokhtari Z, 2017, ADV NUTR, V8, P240, DOI 10.3945/an.116.013151
   Murag S, 2021, GUT LIVER, V15, P206, DOI 10.5009/gnl20127
   Muthiah MD, 2022, DIABETES OBES METAB, V24, P3, DOI 10.1111/dom.14521
   Negro F, 2020, LIVER INT, V40, P72, DOI 10.1111/liv.14362
   Niederreiter L., 2018, Liver Research, V2, P14, DOI [10.1016/j.livres.2018.03.003, DOI 10.1016/J.LIVRES.2018.03.003]
   Ore A, 2019, MEDICINA-LITHUANIA, V55, DOI 10.3390/medicina55020026
   Pais R, 2013, J HEPATOL, V59, P550, DOI 10.1016/j.jhep.2013.04.027
   Panera N, 2016, EXPERT REV GASTROENT, V10, P393, DOI 10.1586/17474124.2016.1110485
   Pant M, 2017, ANN DIAGN PATHOL, V31, P66, DOI 10.1016/j.anndiagpath.2017.02.005
   Pessayre D, 2007, J GASTROEN HEPATOL, V22, pS20, DOI 10.1111/j.1440-1746.2006.04640.x
   Petta S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0087523
   Pierantonelli I, 2019, TRANSPLANTATION, V103, pe1, DOI 10.1097/TP.0000000000002480
   Polyzos SA, 2016, METABOLISM, V65, P1062, DOI 10.1016/j.metabol.2015.11.006
   Quesada-Vázquez S, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9010176
   Ren TY, 2021, NAT REV GASTRO HEPAT, V18, P289, DOI 10.1038/s41575-021-00433-5
   Rich NE, 2018, CLIN GASTROENTEROL H, V16, P198, DOI 10.1016/j.cgh.2017.09.041
   Rinaldi L, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10020270
   Rosato V, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16183415
   Rosen ED, 2014, CELL, V156, P20, DOI 10.1016/j.cell.2013.12.012
   Rowe IA, 2022, CLIN GASTROENTEROL H, V20, P1209, DOI 10.1016/j.cgh.2021.03.005
   Safari Z, 2019, CELL MOL LIFE SCI, V76, P1541, DOI 10.1007/s00018-019-03011-w
   Saltzman ET, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.00061
   Sassi F, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111656
   Schaap FG, 2014, NAT REV GASTRO HEPAT, V11, P55, DOI 10.1038/nrgastro.2013.151
   Schugar RC, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0074806
   Seto WK, 2017, J GASTROENTEROL, V52, P164, DOI 10.1007/s00535-016-1264-3
   Sherriff JL, 2016, ADV NUTR, V7, P5, DOI 10.3945/an.114.007955
   Singh S, 2015, CLIN GASTROENTEROL H, V13, P643, DOI 10.1016/j.cgh.2014.04.014
   Sinha RA, 2018, NAT REV ENDOCRINOL, V14, P259, DOI 10.1038/nrendo.2018.10
   Spahis S, 2017, ANTIOXID REDOX SIGN, V26, P519, DOI 10.1089/ars.2016.6776
   Stojsavljevic S, 2014, WORLD J GASTROENTERO, V20, P18070, DOI 10.3748/wjg.v20.i48.18070
   Sutterwala FS, 2007, J LEUKOCYTE BIOL, V82, P259, DOI 10.1189/jlb.1206755
   Szabo G, 2016, DIGEST DIS SCI, V61, P1314, DOI 10.1007/s10620-015-4002-4
   Tahara K, 2020, JGH OPEN, V4, P400, DOI 10.1002/jgh3.12264
   Taliento AE, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16152755
   Tamura S, 2005, J CLIN INVEST, V115, P1139, DOI 10.1172/JCI200524930
   Tariq Z, 2014, LIVER INT, V34, pE180, DOI 10.1111/liv.12523
   Thelen AM, 2017, TRENDS CELL BIOL, V27, P843, DOI 10.1016/j.tcb.2017.07.006
   Trépo E, 2020, J HEPATOL, V72, P1196, DOI 10.1016/j.jhep.2020.02.020
   Valayannopoulos V, 2017, MOL GENET METAB, V120, P62, DOI 10.1016/j.ymgme.2016.11.002
   Vilarrasa N, 2010, ENDOCRINE, V38, P235, DOI 10.1007/s12020-010-9379-4
   Wainwright P, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17030367
   Wattacheril Julia, 2016, Curr Hepatol Rep, V15, P134
   Wei YL, 2020, INT J ENDOCRINOL MET, V18, DOI 10.5812/ijem.97205
   Yan F, 2014, J HEPATOL, V61, P1358, DOI 10.1016/j.jhep.2014.06.037
   Ye Q, 2020, LANCET GASTROENTEROL, V5, P739, DOI 10.1016/S2468-1253(20)30077-7
   Younes R, 2019, SEMIN LIVER DIS, V39, P86, DOI 10.1055/s-0038-1677517
   Younossi Z, 2018, NAT REV GASTRO HEPAT, V15, P11, DOI 10.1038/nrgastro.2017.109
   Younossi ZM, 2021, HEPATOLOGY, V73, P1194, DOI 10.1002/hep.31420
   Younossi ZM, 2019, J HEPATOL, V71, P793, DOI 10.1016/j.jhep.2019.06.021
   Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431
   Yun Y, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0213692
   Zakharova E, 2017, ATHEROSCLEROSIS, V263, pE60, DOI 10.1016/j.atherosclerosis.2017.06.203
   Zhao F, 2018, ADV EXP MED BIOL, V1061, P79, DOI 10.1007/978-981-10-8684-7_7
   Zou ZY, 2020, J DIGEST DIS, V21, P372, DOI 10.1111/1751-2980.12871
NR 130
TC 18
Z9 18
U1 1
U2 9
PU KEAI PUBLISHING LTD
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, Building 5, Room 411, BEIJING, DONGCHENG
   DISTRICT 100009, PEOPLES R CHINA
SN 2096-2878
EI 2542-5684
J9 LIVER RES-PRC
JI Liver Res.
PD JUN
PY 2022
VL 6
IS 2
BP 72
EP 83
DI 10.1016/j.livres.2022.05.002
PG 12
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA Q2LU7
UT WOS:001055891100001
PM 39958625
OA gold
DA 2025-06-11
ER

PT J
AU Del Rio, R
   Quintanilla, RA
   Orellana, JA
   Retamal, MA
AF Del Rio, Rodrigo
   Quintanilla, Rodrigo A.
   Orellana, Juan A.
   Retamal, Mauricio A.
TI Neuron-Glia Crosstalk in the Autonomic Nervous System and Its Possible
   Role in the Progression of Metabolic Syndrome: A New Hypothesis
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE glia; connexins; metabolic syndrome; mitochondria; tripartite synapse;
   hemichannels
ID ACTIVATED PROTEIN-KINASE; GAP-JUNCTION HEMICHANNELS; PRO-INFLAMMATORY
   CYTOKINES; NITRIC-OXIDE SYNTHASE; GLUTAMATE RELEASE; ATP RELEASE;
   OXIDATIVE STRESS; PANNEXIN 1; MITOCHONDRIAL DYSFUNCTION; CONNEXIN-43
   HEMICHANNELS
AB Metabolic syndrome (MS) is characterized by the following physiological alterations: increase in abdominal fat, insulin resistance, high concentration of triglycerides, low levels of HDL, high blood pressure, and a generalized inflammatory state. One of the pathophysiological hallmarks of this syndrome is the presence of neurohumoral activation, which involve autonomic imbalance associated to hyperactivation of the sympathetic nervous system. Indeed, enhanced sympathetic drive has been linked to the development of endothelial dysfunction, hypertension, stroke, myocardial infarct, and obstructive sleep apnea. Glial cells, the most abundant cells in the central nervous system, control synaptic transmission, and regulate neuronal function by releasing bioactive molecules called gliotransmitters. Recently, a new family of plasma membrane channels called hemichannels has been described to allow the release of gliotransmitters and modulate neuronal firing rate. Moreover, a growing amount of evidence indicates that uncontrolled hemichannel opening could impair glial cell functions, affecting synaptic transmission and neuronal survival. Given that glial cell functions are disturbed in various metabolic diseases, we hypothesize that progression of MS may relies on hemichannel-dependent impairment of glial-to-neuron communication by a mechanism related to dysfunction of inflammatory response and mitochondrial metabolism of glial cells. In this manuscript, we discuss how glial cells may contribute to the enhanced sympathetic drive observed in MS, and shed light about the possible role of hemichannels in this process.
C1 [Del Rio, Rodrigo; Quintanilla, Rodrigo A.] Univ Autonoma Chile, Ctr Invest Biomed, Santiago, Chile.
   [Del Rio, Rodrigo] Univ Cient Sur, Direcc Invest, Lima, Peru.
   [Orellana, Juan A.] Pontificia Univ Catolica Chile, Escuela Med, Dept Neurol, Santiago, Chile.
   [Retamal, Mauricio A.] Univ Desarrollo, Clin Alemana, Fac Med, Ctr Fisiol Celular & Integrat, Santiago, Chile.
C3 Universidad Autonoma de Chile; Universidad Cientifica del Sur
   (CIENTIFICA); Pontificia Universidad Catolica de Chile; Clinica Alemana;
   Universidad del Desarrollo
RP Quintanilla, RA (corresponding author), Univ Autonoma Chile, Ctr Invest Biomed, Santiago, Chile.
EM rodrigo.quintanilla@uautonoma.cl; mretamal@udd.cl
RI Retamal, Mauricio/AAS-3621-2020; QUINTANILLA, RODRIGO/ABG-8829-2021;
   Orellana, Juan/F-6148-2012; Del Rio, Rodrigo/AAF-8763-2020
OI Orellana, Juan Andres/0000-0003-4076-207X; Retamal, Mauricio
   A./0000-0003-2562-6686; Quintanilla, Rodrigo/0000-0002-9582-6379
FU FONDECYT [1140275, 1140968, 11121133, 1120214]; International Society
   for Neurochemistry; Comision Nacional de investigacion Cientifica y
   Tecnologica [ACT 1104, ACT 1411]
FX This work was financed by FONDECYT 1140275 (to RDR), 1140968 (to RAQ),
   11121133 (to JAO) and 1120214 (to MAR). The Committee for Aid and
   Education in Neurochemistry from the International Society for
   Neurochemistry (to JAO), and Comision Nacional de investigacion
   Cientifica y Tecnologica ACT 1104 (to MAR) and ACT 1411 (to RQ and JAO).
CR Abudara V, 2015, GLIA, V63, P795, DOI 10.1002/glia.22785
   Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Ahmad S, 2002, BIOCHEM J, V365, P693, DOI 10.1042/bj20011572
   Allaman I, 2011, TRENDS NEUROSCI, V34, P76, DOI 10.1016/j.tins.2010.12.001
   Almeida A, 2001, P NATL ACAD SCI USA, V98, P15294, DOI 10.1073/pnas.261560998
   Anderson CM, 2004, J NEUROCHEM, V88, P246, DOI 10.1046/j.1471-4159.2003.02204.x
   Ando K, 2009, FREE RADICAL BIO MED, V47, P213, DOI 10.1016/j.freeradbiomed.2009.04.030
   Angelova PR, 2015, J NEUROSCI, V35, P10460, DOI 10.1523/JNEUROSCI.0045-15.2015
   Araque A, 1999, TRENDS NEUROSCI, V22, P208, DOI 10.1016/S0166-2236(98)01349-6
   Ardiles AO, 2014, FRONT CELL NEUROSCI, V8, DOI 10.3389/fncel.2014.00326
   Avendaño BC, 2015, GLIA, V63, P2058, DOI 10.1002/glia.22877
   Badger AM, 1998, J IMMUNOL, V161, P467
   Baroja-Mazo A, 2013, BBA-BIOMEMBRANES, V1828, P79, DOI 10.1016/j.bbamem.2012.01.002
   BATTER DK, 1992, GLIA, V6, P213, DOI 10.1002/glia.440060309
   Bennett MVL, 2012, BRAIN RES, V1487, P3, DOI 10.1016/j.brainres.2012.08.042
   Bezzi P, 2004, NAT NEUROSCI, V7, P613, DOI 10.1038/nn1246
   Block ML, 2007, NAT REV NEUROSCI, V8, P57, DOI 10.1038/nrn2038
   BROWN GC, 1995, NEUROSCI LETT, V193, P201, DOI 10.1016/0304-3940(95)11703-Y
   Bulcke F, 2015, J TRACE ELEM MED BIO, V32, P168, DOI 10.1016/j.jtemb.2015.07.001
   Calvo-Ochoa E, 2014, J CEREBR BLOOD F MET, V34, P1001, DOI 10.1038/jcbfm.2014.48
   Chénais B, 2002, J NEUROCHEM, V81, P615, DOI 10.1046/j.1471-4159.2002.00864.x
   Chever O, 2014, PHILOS T R SOC B, V369, DOI 10.1098/rstb.2013.0596
   Chever O, 2014, J NEUROSCI, V34, P11228, DOI 10.1523/JNEUROSCI.0015-14.2014
   Clerk A, 1999, J MOL CELL CARDIOL, V31, P2087, DOI 10.1006/jmcc.1999.1040
   Contreras JE, 2002, P NATL ACAD SCI USA, V99, P495, DOI 10.1073/pnas.012589799
   Corti A, 2010, ARCH BIOCHEM BIOPHYS, V500, P107, DOI 10.1016/j.abb.2010.05.014
   Cotrina ML, 2008, GLIA, V56, P1791, DOI 10.1002/glia.20728
   COYLE JT, 1993, SCIENCE, V262, P689, DOI 10.1126/science.7901908
   D'Amico A, 2013, HAND CLINIC, V113, P1437, DOI 10.1016/B978-0-444-59565-2.00013-7
   Davidson JO, 2013, EXP NEUROL, V248, P301, DOI 10.1016/j.expneurol.2013.06.026
   De Bock M, 2011, J CEREBR BLOOD F MET, V31, P1942, DOI 10.1038/jcbfm.2011.86
   Del Rio R, 2015, EXP PHYSIOL, V100, P121, DOI 10.1113/expphysiol.2014.079350
   Del Rio R, 2013, J AM COLL CARDIOL, V62, P2422, DOI 10.1016/j.jacc.2013.07.079
   DERMIETZEL R, 1989, P NATL ACAD SCI USA, V86, P10148, DOI 10.1073/pnas.86.24.10148
   Dobrenis K, 2005, J NEUROSCI RES, V82, P306, DOI 10.1002/jnr.20650
   Moreira MCD, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00234
   Duan SM, 2003, J NEUROSCI, V23, P1320, DOI 10.1523/JNEUROSCI.23-04-01320.2003
   Ebihara L, 2011, INVEST OPHTH VIS SCI, V52, P882, DOI 10.1167/iovs.10-6200
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Elias LAB, 2008, TRENDS NEUROSCI, V31, P243, DOI 10.1016/j.tins.2008.02.007
   Fields RD, 2006, NAT REV NEUROSCI, V7, P423, DOI 10.1038/nrn1928
   Fields RD, 2002, SCIENCE, V298, P556, DOI 10.1126/science.298.5593.556
   Fields RD, 2000, TRENDS NEUROSCI, V23, P625, DOI 10.1016/S0166-2236(00)01674-X
   Figueroa V, 2013, BBA-BIOMEMBRANES, V1828, P1169, DOI 10.1016/j.bbamem.2012.12.006
   Fróes MM, 1999, P NATL ACAD SCI USA, V96, P7541, DOI 10.1073/pnas.96.13.7541
   Frühbeis C, 2013, FRONT CELL NEUROSCI, V7, DOI 10.3389/fncel.2013.00182
   Gao Y, 2014, GLIA, V62, P17, DOI 10.1002/glia.22580
   Garré JM, 2010, P NATL ACAD SCI USA, V107, P22659, DOI 10.1073/pnas.1013793107
   Giaume C, 2013, FRONT PHARMACOL, V4, DOI 10.3389/fphar.2013.00088
   Ginhoux F, 2010, SCIENCE, V330, P841, DOI 10.1126/science.1194637
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Guan ZH, 1997, J BIOL CHEM, V272, P8083, DOI 10.1074/jbc.272.12.8083
   Guimaraes PS, 2014, HYPERTENSION, V63, P1078, DOI 10.1161/HYPERTENSIONAHA.113.01847
   Gutiérrez-Venegas G, 2005, LIFE SCI, V77, P60, DOI 10.1016/j.lfs.2004.12.015
   Guyenet PG, 2006, NAT REV NEUROSCI, V7, P335, DOI 10.1038/nrn1902
   Hamilton N, 2008, GLIA, V56, P734, DOI 10.1002/glia.20649
   Hanisch UK, 2002, GLIA, V40, P140, DOI 10.1002/glia.10161
   Hertz L, 2007, J CEREBR BLOOD F MET, V27, P219, DOI 10.1038/sj.jcbfm.9600343
   Hoekstra JG, 2015, AM J PATHOL, V185, P536, DOI 10.1016/j.ajpath.2014.10.022
   Hwang IK, 2014, NEUROL RES, V36, P824, DOI 10.1179/1743132814Y.0000000330
   Iglesias R, 2008, AM J PHYSIOL-CELL PH, V295, pC752, DOI 10.1152/ajpcell.00228.2008
   Iglesias R, 2009, J NEUROSCI, V29, P7092, DOI 10.1523/JNEUROSCI.6062-08.2009
   Imura Y, 2013, GLIA, V61, P1320, DOI 10.1002/glia.22517
   Inoue K, 2007, J NEUROCHEM, V102, P1447, DOI 10.1111/j.1471-4159.2007.04824.x
   Jin SJ, 2009, TOHOKU J EXP MED, V217, P87, DOI 10.1620/tjem.217.87
   Karpuk N, 2011, J NEUROSCI, V31, P414, DOI 10.1523/JNEUROSCI.5247-10.2011
   Kettenmann H, 2011, PHYSIOL REV, V91, P461, DOI 10.1152/physrev.00011.2010
   Khoo Michael C K, 2013, IEEE Rev Biomed Eng, V6, P143, DOI 10.1109/RBME.2012.2232651
   Kim B, 2012, TRENDS ENDOCRIN MET, V23, P133, DOI 10.1016/j.tem.2011.12.004
   KIMELBERG HK, 1990, J NEUROSCI, V10, P1583
   LAI JCK, 1992, CAN J PHYSIOL PHARM, V70, pS130, DOI 10.1139/y92-254
   Lane DJR, 2010, BIOCHEM J, V432, P123, DOI 10.1042/BJ20101317
   Lane DJR, 2009, FREE RADICAL BIO MED, V47, P485, DOI 10.1016/j.freeradbiomed.2009.06.003
   LAWSON LJ, 1990, NEUROSCIENCE, V39, P151, DOI 10.1016/0306-4522(90)90229-W
   Lee S, 2010, SCIENCE, V330, P790, DOI 10.1126/science.1184334
   Li DP, 2008, J PHYSIOL-LONDON, V586, P1637, DOI 10.1113/jphysiol.2007.149732
   Licht CMM, 2013, J CLIN ENDOCR METAB, V98, P2484, DOI 10.1210/jc.2012-3104
   Licht CMM, 2010, J CLIN ENDOCR METAB, V95, P2458, DOI 10.1210/jc.2009-2801
   Litvinova L, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00020
   Locovei S, 2006, FEBS LETT, V580, P239, DOI 10.1016/j.febslet.2005.12.004
   Lutsenko S, 2010, METALLOMICS, V2, P596, DOI 10.1039/c0mt00006j
   Ma WW, 2014, LIFE SCI, V110, P53, DOI 10.1016/j.lfs.2014.07.018
   Mandal A, 2015, EXP EYE RES, V132, P52, DOI 10.1016/j.exer.2015.01.012
   Avalos AM, 2009, J CELL SCI, V122, P3462, DOI 10.1242/jcs.034827
   Marina N, 2013, BASIC RES CARDIOL, V108, DOI 10.1007/s00395-012-0317-x
   Mitchell MD, 2007, AM J PHYSIOL-HEART C, V292, pH1139, DOI 10.1152/ajpheart.00881.2005
   Montero TD, 2015, NEUROSCIENCE, V286, P45, DOI 10.1016/j.neuroscience.2014.11.048
   Moore AR, 2014, P NATL ACAD SCI USA, V111, pE3919, DOI 10.1073/pnas.1405253111
   Morita M, 2007, GLIA, V55, P508, DOI 10.1002/glia.20471
   Moss DW, 2001, EUR J NEUROSCI, V13, P529, DOI 10.1046/j.1460-9568.2001.01418.x
   Motori E, 2013, CELL METAB, V18, P844, DOI 10.1016/j.cmet.2013.11.005
   Mrak RE, 2005, NEUROBIOL AGING, V26, P349, DOI 10.1016/j.neurobiolaging.2004.05.010
   Oberheim NA, 2006, TRENDS NEUROSCI, V29, P547, DOI 10.1016/j.tins.2006.08.004
   Orellana JA, 2015, FRONT CELL NEUROSCI, V9, DOI 10.3389/fncel.2015.00102
   Orellana JA, 2014, FRONT PHYSIOL, V5, DOI 10.3389/fphys.2014.00193
   Orellana JA, 2013, NEUROPHARMACOLOGY, V75, P567, DOI 10.1016/j.neuropharm.2013.02.020
   Orellana JA, 2013, GLIA, V61, P2023, DOI 10.1002/glia.22573
   Orellana JA, 2012, REV NEUROSCIENCE, V23, P163, DOI 10.1515/revneuro-2011-0065
   Orellana JA, 2012, GLIA, V60, P53, DOI 10.1002/glia.21246
   Orellana JA, 2011, J NEUROSCI, V31, P4962, DOI 10.1523/JNEUROSCI.6417-10.2011
   Orellana JA, 2011, J NEUROCHEM, V118, P826, DOI 10.1111/j.1471-4159.2011.07210.x
   Orellana JA, 2009, ANTIOXID REDOX SIGN, V11, P369, DOI 10.1089/ars.2008.2130
   Reyes EP, 2014, FRONT CELL NEUROSCI, V8, DOI 10.3389/fncel.2014.00123
   Palatini P, 2006, J HYPERTENS, V24, P1375, DOI 10.1097/01.hjh.0000234118.25401.1c
   Pan HC, 2015, GLIA, V63, P877, DOI 10.1002/glia.22790
   Panchin YV, 2005, J EXP BIOL, V208, P1415, DOI 10.1242/jeb.01547
   Park J, 2015, NEUROSCI LETT, V584, P191, DOI 10.1016/j.neulet.2014.10.016
   Paton JFR, 2013, HYPERTENSION, V61, P5, DOI 10.1161/HYPERTENSIONAHA.111.00064
   Pekny M, 2014, PHYSIOL REV, V94, P1077, DOI 10.1152/physrev.00041.2013
   Perea G, 2009, TRENDS NEUROSCI, V32, P421, DOI 10.1016/j.tins.2009.05.001
   Prochnow N, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051767
   Quintanilla RA, 2012, ARCH MED RES, V43, P632, DOI 10.1016/j.arcmed.2012.10.016
   Ranat S, 2007, NEUROSCI LETT, V415, P45, DOI 10.1016/j.neulet.2006.12.043
   Raza H, 2015, CELL PHYSIOL BIOCHEM, V35, P1241, DOI 10.1159/000373947
   Retamal MA, 2006, P NATL ACAD SCI USA, V103, P4475, DOI 10.1073/pnas.0511118103
   Retamal MA, 2007, J NEUROSCI, V27, P13781, DOI 10.1523/JNEUROSCI.2042-07.2007
   Retamal MA, 2015, FRONT CELL NEUROSCI, V9, DOI 10.3389/fncel.2015.00267
   Retamal MA, 2014, FRONT PHYSIOL, V5, DOI 10.3389/fphys.2014.00080
   Retamal MA, 2011, PFLUG ARCH EUR J PHY, V461, P635, DOI 10.1007/s00424-011-0936-3
   Rosales-Corral S, 2010, ANTIOXID REDOX SIGN, V13, P193, DOI 10.1089/ars.2009.2629
   Rossa C, 2006, J INTERF CYTOK RES, V26, P719, DOI 10.1089/jir.2006.26.719
   Rossi DJ, 2000, NATURE, V403, P316, DOI 10.1038/35002090
   Rouach N, 2008, SCIENCE, V322, P1551, DOI 10.1126/science.1164022
   Rozental R, 2001, DEV NEUROSCI-BASEL, V23, P420, DOI 10.1159/000048729
   Rudkouskaya A, 2008, J NEUROCHEM, V105, P2260, DOI 10.1111/j.1471-4159.2008.05312.x
   Sáez JC, 2005, BBA-BIOMEMBRANES, V1711, P215, DOI 10.1016/j.bbamem.2005.01.014
   Sáez JC, 2003, PHYSIOL REV, V83, P1359, DOI 10.1152/physrev.00007.2003
   Sandau US, 2011, ENDOCRINOLOGY, V152, P2364, DOI 10.1210/en.2010-1435
   Santiago MF, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025178
   Scemes E, 1998, GLIA, V24, P65, DOI 10.1002/(SICI)1098-1136(199809)24:1<65::AID-GLIA7>3.0.CO;2-#
   Schafer DP, 2013, GLIA, V61, P24, DOI 10.1002/glia.22389
   Scheiber IF, 2014, PROG NEUROBIOL, V116, P33, DOI 10.1016/j.pneurobio.2014.01.002
   Scheiber IF, 2010, NEUROCHEM INT, V57, P314, DOI 10.1016/j.neuint.2010.06.010
   Scheiber IF, 2010, NEUROCHEM INT, V56, P451, DOI 10.1016/j.neuint.2009.12.002
   Schlaich M, 2015, LANCET DIABETES ENDO, V3, P148, DOI 10.1016/S2213-8587(14)70033-6
   Schock SC, 2008, BIOCHEM BIOPH RES CO, V368, P138, DOI 10.1016/j.bbrc.2008.01.054
   Shahidullah M, 2014, EXP EYE RES, V118, P20, DOI 10.1016/j.exer.2013.11.004
   Sheng WS, 2013, NEUROCHEM RES, V38, P2148, DOI 10.1007/s11064-013-1123-z
   Simard M, 2003, J NEUROSCI, V23, P9254
   Söhl G, 2004, CARDIOVASC RES, V62, P228, DOI 10.1016/j.cardiores.2003.11.013
   Stehberg J, 2012, FASEB J, V26, P3649, DOI 10.1096/fj.11-198416
   Stephen TL, 2014, BIOCHEM SOC T, V42, P1302, DOI 10.1042/BST20140195
   Stern JE, 2013, AUTON NEUROSCI-BASIC, V175, P51, DOI 10.1016/j.autneu.2012.12.009
   Stout CE, 2002, J BIOL CHEM, V277, P10482, DOI 10.1074/jbc.M109902200
   Straznicky NE, 2012, J CLIN ENDOCR METAB, V97, P605, DOI 10.1210/jc.2011-2320
   Streit WJ, 2001, NEUROTOXICOLOGY, V22, P619, DOI 10.1016/S0161-813X(01)00033-X
   Stridh MH, 2008, J BIOL CHEM, V283, P10347, DOI 10.1074/jbc.M704153200
   Suadicani SO, 2006, J NEUROSCI, V26, P1378, DOI 10.1523/JNEUROSCI.3902-05.2006
   SWANSON LW, 1983, ANNU REV NEUROSCI, V6, P269, DOI 10.1146/annurev.ne.06.030183.001413
   Takano T, 2005, P NATL ACAD SCI USA, V102, P16466, DOI 10.1073/pnas.0506382102
   Takeuchi H, 2006, J BIOL CHEM, V281, P21362, DOI 10.1074/jbc.M600504200
   Takeuchi H, 2014, FRONT CELL NEUROSCI, V8, DOI 10.3389/fncel.2014.00189
   Takeuchi H, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0021108
   Tentolouris N, 2006, ANN NY ACAD SCI, V1083, P129, DOI 10.1196/annals.1367.010
   Thaler JP, 2012, J CLIN INVEST, V122, P153, DOI 10.1172/JCI59660
   Thayer JF, 2010, INT J CARDIOL, V141, P122, DOI 10.1016/j.ijcard.2009.09.543
   Thompson RJ, 2006, SCIENCE, V312, P924, DOI 10.1126/science.1126241
   Tomassoni D, 2013, NEUROSCI LETT, V543, P136, DOI 10.1016/j.neulet.2013.03.025
   Torres A, 2012, SCI SIGNAL, V5, DOI 10.1126/scisignal.2002160
   Tremarin CD, 2014, BRIT J NUTR, V111, P207, DOI 10.1017/S0007114513002493
   Tremblay ME, 2010, PLOS BIOL, V8, DOI 10.1371/journal.pbio.1000527
   Treviño S, 2015, SYNAPSE, V69, P421, DOI 10.1002/syn.21832
   Vance KM, 2015, J NEUROSCI, V35, P776, DOI 10.1523/JNEUROSCI.3105-14.2015
   Verberne AJM, 1999, J PHYSIOL-LONDON, V517, P477, DOI 10.1111/j.1469-7793.1999.0477t.x
   Voloboueva LA, 2013, FEBS LETT, V587, P756, DOI 10.1016/j.febslet.2013.01.067
   Volterra A, 2005, NAT REV NEUROSCI, V6, P626, DOI 10.1038/nrn1722
   von Bernhardi R, 2012, ANTIOXID REDOX SIGN, V16, P974, DOI 10.1089/ars.2011.4082
   Wake H, 2013, TRENDS NEUROSCI, V36, P209, DOI 10.1016/j.tins.2012.11.007
   Wang X, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047429
   Weilinger NL, 2012, J NEUROSCI, V32, P12579, DOI 10.1523/JNEUROSCI.1267-12.2012
   Westermann B, 2010, NAT REV MOL CELL BIO, V11, P872, DOI 10.1038/nrm3013
   Wilson JX, 1997, CAN J PHYSIOL PHARM, V75, P1149, DOI 10.1139/cjpp-75-10-11-1149
   Wilson JX, 2000, BRAIN RES, V858, P61, DOI 10.1016/S0006-8993(99)02433-6
   Wulsin LR, 2015, J CLIN ENDOCR METAB, V100, P2443, DOI 10.1210/jc.2015-1748
   Xu Z, 2006, LIFE SCI, V79, P1895, DOI 10.1016/j.lfs.2006.06.023
   Ye ZC, 2003, J NEUROSCI, V23, P3588, DOI 10.1523/jneurosci.23-09-03588.2003
   Yeh CW, 2015, NEUROBIOL AGING, V36, P2984, DOI 10.1016/j.neurobiolaging.2015.07.022
   Zhang L, 2008, J NEUROSCI RES, V86, P2281, DOI 10.1002/jnr.21675
   Zhang Q, 2004, P NATL ACAD SCI USA, V101, P9441, DOI 10.1073/pnas.0401960101
   Zucker IH, 2012, HEART FAIL CLIN, V8, P87, DOI 10.1016/j.hfc.2011.08.007
NR 180
TC 12
Z9 13
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD DEC 1
PY 2015
VL 6
AR 350
DI 10.3389/fphys.2015.00350
PG 13
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA VF7RT
UT WOS:000443545400001
PM 26648871
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kajioka, T
   Miura, K
   Kitahara, Y
   Yamagishi, S
AF Kajioka, T.
   Miura, K.
   Kitahara, Y.
   Yamagishi, S.
TI Potential utility of combination therapy with nateglinide and
   telmisartan for metabolic derangements in Zucker Fatty rats
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE insulin resistance; metabolic syndrome; postprandial hyperglycemia;
   telmisartan
ID OXIDATIVE STRESS; COMPLICATIONS; HYPERGLYCEMIA
AB The metabolic syndrome is strongly associated with insulin resistance and has been recognized as a cluster of risk factors for cardiovascular disease. Insulin resistance and/or impaired early-phase insulin secretion are major determinants of postprandial hyperglycemia. In this study, we investigated the potential utility of combination therapy with telmisartan, an angiotensin 11 receptor blocker and nateglinide, a rapid-onset/short-duration insulinotropic agent, for the treatment of postprandial hyperglycemia and metabolic derangements in Zucker Fatty (ZF) rats. ZF rats fed twice daily were given vehicle, 50 mg/kg of nateglinide, 5 mg/kg of telmisartan, or both for 6 weeks. Combination therapy with nateglinide and telmisartan for 2 weeks ameliorated postprandial hyperglycemia in ZF rats fed twice daily. Further-more, 6-week treatment with nateglinide and telmisartan not only decreased fasting plasma insulin, triglycerides, and free fatty acid levels, but also improved the responses of blood glucose to insulin and subsequently reduced the decremental glucose areas under the curve in the ZF rats. Combination therapy also restored the decrease of plasma adiponectin levels in the ZF rats. Monotherapy with nateglinide or telmisartan alone did not significantly improve these metabolic parameters. These observations demonstrate that combination therapy with nateglinide and telmisartan may improve the metabolic derangements by ameliorating early phase of insulin secretion as well as insulin resistance in ZF rats fed twice daily. Our present findings suggest that the combination therapy with nateglinide and telmisartan could be a promising therapeutic strategy for the treatment of the metabolic syndrome.
C1 [Yamagishi, S.] Kurume Univ, Sch Med, Div Cardiovasc Med, Dept Med, Kurume, Fukuoka 8300011, Japan.
   [Kajioka, T.; Miura, K.; Kitahara, Y.] Pharmaceut Res Labs, Kawasaki, Kanagawa, Japan.
C3 Kurume University
RP Yamagishi, S (corresponding author), Kurume Univ, Sch Med, Div Cardiovasc Med, Dept Med, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
EM shoichi@med.kurume-u.ac.jp
OI KAJIOKA, TOSHIFUMI/0009-0004-3520-852X
CR Araki K, 2006, HYPERTENSION, V48, P51, DOI 10.1161/01.HYP.0000225402.69580.1d
   Benson SC, 2004, HYPERTENSION, V43, P993, DOI 10.1161/01.HYP.0000123072.34629.57
   Ceriello A, 1999, DIABETES NUTR METAB, V12, P42
   Heine RJ, 2002, DIABETOLOGIA, V45, P461, DOI 10.1007/s00125-001-0726-0
   Hsueh WA, 2003, AM J CARDIOL, V92, p10J, DOI 10.1016/S0002-9149(03)00611-8
   Kitahara Y, 2002, METABOLISM, V51, P1452, DOI 10.1053/meta.2002.35195
   Kurowska EM, 2002, CURR PHARM DESIGN, V8, P155, DOI 10.2174/1381612023396429
   Miura Y, 2005, DIABETES CARE, V28, P757, DOI 10.2337/diacare.28.3.757
   Rösen P, 2006, HORM METAB RES, V38, P575, DOI 10.1055/s-2006-950397
   Ronson RS, 1999, CARDIOVASC RES, V44, P47, DOI 10.1016/S0008-6363(99)00184-4
   Rösen P, 2001, DIABETES-METAB RES, V17, P189, DOI 10.1002/dmrr.196
   Scheen A J, 2004, Minerva Endocrinol, V29, P31
   Schupp M, 2004, CIRCULATION, V109, P2054, DOI 10.1161/01.CIR.0000127955.36250.65
   Takano H, 2004, CURR PHARM DESIGN, V10, P2779, DOI 10.2174/1381612043383719
   Yamagishi S, 2005, DRUG EXP CLIN RES, V31, P123
   Yamagishi S, 2005, CURR PHARM DESIGN, V11, P2279, DOI 10.2174/1381612054367300
   Yamagishi S, 2005, MED HYPOTHESES, V64, P476, DOI 10.1016/j.mehy.2004.09.015
NR 17
TC 7
Z9 7
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD DEC
PY 2007
VL 39
IS 12
BP 889
EP 893
DI 10.1055/s-2007-992798
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 251GL
UT WOS:000252360500008
PM 17987547
DA 2025-06-11
ER

PT J
AU Bellien, J
   Bozec, E
   Bounoure, F
   Khettab, H
   Malloizel-Delaunay, J
   Skiba, M
   Iacob, M
   Donnadieu, N
   Coquard, A
   Morio, B
   Laillet, B
   Rigaudière, JP
   Chardigny, JM
   Monteil, C
   Vendeville, C
   Mercier, A
   Cailleux, AF
   Blanchard, A
   Amar, J
   Fezeu, LK
   Pannier, B
   Bura-Rivière, A
   Boutouyrie, P
   Joannidès, R
AF Bellien, Jeremy
   Bozec, Erwan
   Bounoure, Frederic
   Khettab, Hakim
   Malloizel-Delaunay, Julie
   Skiba, Mohamed
   Iacob, Michele
   Donnadieu, Nathalie
   Coquard, Aude
   Morio, Beatrice
   Laillet, Brigitte
   Rigaudiere, Jean-Paul
   Chardigny, Jean-Michel
   Monteil, Christelle
   Vendeville, Cathy
   Mercier, Alain
   Cailleux, Anne-Francoise
   Blanchard, Anne
   Amar, Jacques
   Fezeu, Leopold K.
   Pannier, Bruno
   Bura-Riviere, Alessandra
   Boutouyrie, Pierre
   Joannides, Robinson
TI The effect of camelina oil on vascular function in essential
   hypertensive patients with metabolic syndrome: a randomized,
   placebo-controlled, double-blind study
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE camelina oil; alpha-linolenic acid; vascular function; essential
   hypertension; metabolic syndrome
ID ALPHA-LINOLENIC ACID; N-3 FATTY-ACIDS; ARTERIAL STIFFNESS;
   BLOOD-PRESSURE; EICOSAPENTAENOIC ACID; DOCOSAHEXAENOIC ACID; ENDOTHELIAL
   FUNCTION; RISK-FACTORS; METAANALYSIS; OMEGA-3-FATTY-ACIDS
AB Background: The effects of a dietary supplementation with the vegetable omega-3 alpha-linolenic acid (ALA) on cardiovascular homeostasis are unclear. In this context. it would be interesting to assess the effects of camelina oil.
   Objective: This study aimed to assess the cardiovascular and metabolic effects of camelina oil in hypertensive patients with metabolic syndrome.
   Methods: In a double-blind, placebo-controlled randomized study, treated essential hypertensive patients with metabolic syndrome received, during 6 mo, either cyclodextrin-complexed camelina oil containing approximate to 1.5 g ALA/d (n = 40) or an isocaloric placebo (n = 41), consisting of the same quantity of cyclodextrins and wheat starch. Anthropometric data, plasma lipids. glycemia, insulinemia. creatininemia. TBARs, high-sensitivity C-reactive protein, and n-3, n-6, and n-9 fatty acids in erythrocyte membranes were measured. Peripheral and central blood pressures, arterial stiffness, carotid intima-media thickness, and brachial artery endothelium-dependent flow-mediated dilatation (FMD) and endothelium-independent dilatation were assessed.
   Results: Compared with placebo. camelina oil increased ALA (mean +/- SD: 0 +/- 0.04 compared with 0.08 +/- 0.06%. P <0.001), its elongation product EPA (0 +/- 0.5 compared with 0.16 +/- 0.65%, P <0.05), and the n-9 gondoic acid (GA; 0 f 0.04 compared with 0.08 +/- 0.04%, P <0.001). No between-group difference was observed for cardiovascular parameters. Ilowever, changes in FMD were associated with the magnitude of changes in EPA (r = 0.26, P = 0.03). Compared with placebo. camelina oil increased fasting glycemia (-0.2 +/- 0.6 compared with 0.3 +/- 0.5 mmol/L. P <0.001) and HOMA-IR index (-0.8 +/- 25 compared with 0.5 +/- 0.9. P <0.01). without affecting plasma lipids, or inflammatory and oxidative stress markers. Changes in HOMA-IR index were correlated with the magnitude of changes in GA (r = 0.32, P <0.01). Nutritional intake remained similar between groups.
   Conclusion: ALA supplementation with camelina oil did not improve vascular function but adversely affected glucose metabolism in hypertensive patients with metabolic syndrome. Whether this adverse effect on insulin sensitivity is related to GA enrichment, remains to be elucidated.
C1 [Bellien, Jeremy; Iacob, Michele; Joannides, Robinson] Rouen Univ Hosp, Dept Pharmacol, Rouen, France.
   [Bellien, Jeremy; Iacob, Michele; Joannides, Robinson] Normandie Univ, Rouen Normandy Univ UNIROUEN, Inst Natl Santa & Rech Med INSERM, Federat Hosp Univ CArdiac Res Network Aort VAlve, Rouen, France.
   [Bellien, Jeremy; Cailleux, Anne-Francoise; Joannides, Robinson] Rouen Univ Hosp, Ctr Invest Clin CIC INSERM 1404, Rouen, France.
   [Bozec, Erwan; Khettab, Hakim; Boutouyrie, Pierre] Univ Paris, Serv Pharmacol, INSERM U970, Equipe 7, Paris, France.
   [Bozec, Erwan] Univ Lorraine, Ctr Invest Clin Plurithemat, Nancy, France.
   [Bozec, Erwan] CHRU Nancy, INSERM 1433, Nancy, France.
   [Bozec, Erwan] Inserm DCAC, Nancy, France.
   [Bozec, Erwan] F CRIN INI CRCT Cardiovasc & Renal Clin Trialists, Nancy, France.
   [Bounoure, Frederic] Normandie Univ, UNIROUEN, Pharm Galen, INSERM U1239, Rouen, France.
   [Khettab, Hakim; Skiba, Mohamed; Boutouyrie, Pierre] HEGP, AP HP, Serv Pharmacol, Paris, France.
   [Malloizel-Delaunay, Julie; Bura-Riviere, Alessandra] Univ Hosp Toulouse, Dept Vasc Med, Toulouse, France.
   [Donnadieu, Nathalie; Coquard, Aude] Rouen Univ Hosp, Dept Pharm, Rouen, France.
   [Morio, Beatrice; Laillet, Brigitte; Rigaudiere, Jean-Paul; Chardigny, Jean-Michel] Univ Clermont Auvergne, Inst Natl Rech Agr Alimentat & Environm INRAE, Unite Nutr Humaine UNH, CRNH Auvergne, Clermont Ferrand, France.
   [Monteil, Christelle; Vendeville, Cathy] Normandie Univ, ABTE, UNICAEN, UNIROUEN, Rouen, France.
   [Mercier, Alain] Univ Paris 13, SMBH, Dept Gen Practice, Bobigny, France.
   [Blanchard, Anne] Hop Europeen Georges Pompidou, AP HP, Ctr Invest Clin INSERM CIC 1418, Paris, France.
   [Amar, Jacques] Toulouse Univ III, Dept Arterial Hypertens, Toulouse, France.
   [Fezeu, Leopold K.] Univ Paris CRESS, Sorbonne Paris Nord Univ, INSERM U1153, INRAE U1125,CNAM,Nutr Epidemiol Res Team EREN,Epi, Bobigny, France.
   [Pannier, Bruno] Ctr Hosp FH Manhes, Dept Nephrol, Fleury Merogis, France.
C3 Universite de Rouen Normandie; CHU de Rouen; Universite de Rouen
   Normandie; Universite de Rouen Normandie; CHU de Rouen; Universite Paris
   Cite; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite de Lorraine; CHU de Nancy; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Institut National de la
   Sante et de la Recherche Medicale (Inserm); Universite de Rouen
   Normandie; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Assistance Publique Hopitaux Paris (APHP); Universite Paris
   Cite; Hopital Universitaire Europeen Georges-Pompidou - APHP; CHU de
   Toulouse; Universite de Toulouse; Universite Toulouse III - Paul
   Sabatier; Universite de Rouen Normandie; CHU de Rouen; INRAE; Universite
   Clermont Auvergne (UCA); Universite de Rouen Normandie; Universite de
   Caen Normandie; Universite Paris 13; Assistance Publique Hopitaux Paris
   (APHP); Universite Paris Cite; Hopital Universitaire Europeen
   Georges-Pompidou - APHP; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Paris Cite; heSam Universite;
   Conservatoire National Arts & Metiers (CNAM); INRAE
RP Bellien, J (corresponding author), Rouen Univ Hosp, Dept Pharmacol, Rouen, France.; Bellien, J (corresponding author), Normandie Univ, Rouen Normandy Univ UNIROUEN, Inst Natl Santa & Rech Med INSERM, Federat Hosp Univ CArdiac Res Network Aort VAlve, Rouen, France.; Bellien, J (corresponding author), Rouen Univ Hosp, Ctr Invest Clin CIC INSERM 1404, Rouen, France.
EM jeremy.bellien@chu-rouen.fr
RI Monteil, Christelle/ABF-3312-2022; khettab, hakim/AAQ-5819-2021;
   boutouyrie, pierre/HGT-8201-2022; Morio, Béatrice/JCD-6492-2023;
   Boutouyrie, Pierre/J-8592-2015; Morio, Beatrice/G-3571-2018
OI Boutouyrie, Pierre/0000-0002-4375-3569; Lab, Carmen/0000-0002-5935-3236;
   Morio, Beatrice/0000-0002-2418-1438; Monteil,
   Christelle/0000-0002-4981-0800; Jeremy, Bellien/0000-0002-0383-2342;
   khettab, hakim/0000-0001-8351-3845
CR Abdelhamid AS, 2018, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003177.pub3
   Artiss JD, 2006, METABOLISM, V55, P195, DOI 10.1016/j.metabol.2005.08.012
   Avis de l'Anses, RAPP EXP COLL DEC 20
   Baker EJ, 2016, PROG LIPID RES, V64, P30, DOI 10.1016/j.plipres.2016.07.002
   Bemelmans WJE, 2004, EUR J CLIN NUTR, V58, P1083, DOI 10.1038/sj.ejcn.1601938
   Benhamou Y, 2014, ARTHRITIS RHEUMATOL, V66, P3210, DOI 10.1002/art.38785
   Bhardwaj R, 2018, INDIAN HEART J, V70, P497, DOI 10.1016/j.ihj.2018.01.030
   Brown TJ, 2019, BMJ-BRIT MED J, V366, DOI 10.1136/bmj.l4697
   Caligiuri SPB, 2016, HYPERTENSION, V68, P1031, DOI 10.1161/HYPERTENSIONAHA.116.07834
   Campbell F, 2013, EUR J PREV CARDIOL, V20, P107, DOI 10.1177/2047487312437056
   Chen HY, 2020, FOOD FUNCT, V11, P1919, DOI [10.1039/c9fo03052b, 10.1039/C9FO03052B]
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Colussi G, 2014, J ATHEROSCLER THROMB, V21, P941, DOI 10.5551/jat.22921
   De Caterina R, 2011, NEW ENGL J MED, V364, P2439, DOI 10.1056/NEJMra1008153
   Delgado GE, 2017, J CLIN LIPIDOL, V11, P126, DOI 10.1016/j.jacl.2016.10.015
   Din JN, 2011, EUR J CLIN NUTR, V65, P234, DOI 10.1038/ejcn.2010.233
   Du YJ, 2020, PROSTAG LEUKOTR ESS, V160, DOI 10.1016/j.plefa.2020.102160
   Estaquio C, 2008, J NUTR, V138, P946, DOI 10.1093/jn/138.5.946
   Fang Y, 2011, FUND CLIN PHARMACOL, V25, P323, DOI 10.1111/j.1472-8206.2010.00839.x
   FLOURIE B, 1993, J NUTR, V123, P676, DOI 10.1093/jn/123.4.676
   Ghiadoni L, 2008, HYPERTENSION, V51, P440, DOI 10.1161/HYPERTENSIONAHA.107.103093
   Grunberger G, 2007, DIABETES-METAB RES, V23, P56, DOI 10.1002/dmrr.687
   Hamburg NM, 2008, AM J CARDIOL, V101, P82, DOI 10.1016/j.amjcard.2007.07.053
   Joris PJ, 2020, CLIN NUTR, V39, P2413, DOI 10.1016/j.clnu.2019.11.032
   Jovanovski E, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000006531
   Kang JX, 2005, WORLD REV NUTR DIET, V95, P93, DOI 10.1159/000088276
   Karvonen HM, 2002, METABOLISM, V51, P1253, DOI 10.1053/meta.2002.35183
   Khalesi S, 2015, J NUTR, V145, P758, DOI 10.3945/jn.114.205302
   Kromhout D, 2010, NEW ENGL J MED, V363, P2015, DOI 10.1056/NEJMoa1003603
   Malaisse WJ, 2008, INT J MOL MED, V22, P133
   Maltete D, 2010, ATHEROSCLEROSIS, V211, P486, DOI 10.1016/j.atherosclerosis.2010.04.002
   Manninen S, 2019, NUTR METAB CARDIOVAS, V29, P51, DOI 10.1016/j.numecd.2018.10.002
   Maruhashi T, 2020, J AM HEART ASSOC, V9, DOI 10.1161/JAHA.119.013915
   Mattace-Raso FUS, 2010, EUR HEART J, V31, P2338, DOI 10.1093/eurheartj/ehq165
   Miller PE, 2014, AM J HYPERTENS, V27, P885, DOI 10.1093/ajh/hpu024
   Parikh M, 2019, NUTRIENTS, V11, DOI 10.3390/nu11051171
   Pase MP, 2011, BRIT J NUTR, V106, P974, DOI 10.1017/S0007114511002819
   Portolesi R, 2007, J LIPID RES, V48, P1592, DOI 10.1194/jlr.M700081-JLR200
   Poudyal H, 2011, PROG LIPID RES, V50, P372, DOI 10.1016/j.plipres.2011.06.003
   Ros E, 2004, CIRCULATION, V109, P1609, DOI 10.1161/01.CIR.0000124477.91474.FF
   Schillaci G, 2004, J AM COLL CARDIOL, V43, P1817, DOI 10.1016/j.jacc.2003.12.049
   Schwab US, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700503
   Serhan CN, 2018, J CLIN INVEST, V128, P2657, DOI 10.1172/JCI97943
   Siscovick DS, 2017, CIRCULATION, V135, pe867, DOI 10.1161/CIR.0000000000000482
   Skilton MR, 2015, J PEDIATR-US, V166, P1252, DOI 10.1016/j.jpeds.2015.01.020
   Smink W, 2012, ANIMAL, V6, P262, DOI 10.1017/S1751731111001479
   Su H, 2018, EUR J NUTR, V57, P877, DOI 10.1007/s00394-017-1386-2
   Tavarini S, 2021, PLANTS-BASEL, V10, DOI 10.3390/plants10010156
   Wagner A, 2015, EUR J CLIN NUTR, V69, P436, DOI 10.1038/ejcn.2014.219
   Wang QQ, 2012, ATHEROSCLEROSIS, V221, P536, DOI 10.1016/j.atherosclerosis.2012.01.006
   West SG, 2010, J AM COLL NUTR, V29, P595, DOI 10.1080/07315724.2010.10719898
   Xin W, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046028
NR 52
TC 4
Z9 5
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD MAR 4
PY 2022
VL 115
IS 3
BP 694
EP 704
DI 10.1093/ajcn/nqab374
EA JAN 2022
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ZM3LU
UT WOS:000764264200012
PM 34791007
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Varalda, M
   Venetucci, J
   Nikaj, H
   Kankara, CR
   Garro, G
   Keivan, N
   Bettio, V
   Marzullo, P
   Antona, A
   Valente, G
   Gentilli, S
   Capello, D
AF Varalda, Marco
   Venetucci, Jacopo
   Nikaj, Herald
   Kankara, Chaitanya Reddy
   Garro, Giulia
   Keivan, Nazanin
   Bettio, Valentina
   Marzullo, Paolo
   Antona, Annamaria
   Valente, Guido
   Gentilli, Sergio
   Capello, Daniela
TI Second-Generation Antipsychotics Induce Metabolic Disruption in Adipose
   Tissue-Derived Mesenchymal Stem Cells Through an aPKC-Dependent Pathway
SO CELLS
LA English
DT Article
DE second-generation antipsychotics; insulin resistance; adipose tissue;
   adipose-derived mesenchymal stem cells; insulin signaling; endocytosis;
   lysosomes; PKC zeta
ID PROTEIN-KINASE-C; INSULIN-RECEPTOR SUBSTRATE-1; PHOSPHATIDIC-ACID;
   PHOSPHOLIPASE-D; IN-VITRO; OBESITY; PHOSPHORYLATION; ENDOCYTOSIS;
   AUTOPHAGY; ZETA
AB Metabolic syndrome (MetS) is a cluster of metabolic abnormalities, including visceral obesity, dyslipidemia, and insulin resistance. In this regard, visceral white adipose tissue (vWAT) plays a critical role, influencing energy metabolism, immunomodulation, and oxidative stress. Adipose-derived stem cells (ADSCs) are key players in these processes within vWAT. While second-generation antipsychotics (SGAs) have significantly improved treatments for mental health disorders, their chronic use is associated with an increased risk of MetS. In this study, we explored the impact of SGAs on ADSCs to better understand their role in MetS and identify potential therapeutic targets. Our findings reveal that olanzapine disrupts lipid droplet formation during adipogenic differentiation, impairing insulin receptor endocytosis, turnover, and signaling. SGAs also alter the endolysosomal compartment, leading to acidic vesicle accumulation and increased lysosomal biogenesis through TFEB activation. PKC zeta is crucial for the SGA-induced nuclear translocation of TFEB and acidic vesicle formation. Notably, inhibiting PKC zeta restored insulin receptor tyrosine phosphorylation, normalized receptor turnover, and improved downstream signaling following olanzapine treatment. This activation of PKC zeta by olanzapine is driven by increased phosphatidic acid synthesis via phospholipase D (PLD), following G protein-coupled receptor (GPCR) signaling activation. Overall, olanzapine and clozapine disrupt endolysosomal homeostasis and insulin signaling in a PKC zeta-dependent manner. These findings highlight SGAs as valuable tools for uncovering cellular dysfunction in vWAT during MetS and may guide the development of new therapeutic strategies to mitigate the metabolic side effects of these drugs.
C1 [Varalda, Marco; Venetucci, Jacopo; Kankara, Chaitanya Reddy; Garro, Giulia; Keivan, Nazanin; Bettio, Valentina; Marzullo, Paolo; Antona, Annamaria; Valente, Guido; Gentilli, Sergio; Capello, Daniela] Univ Piemonte Orientale, Ctr Excellence Aging Sci, Dept Translat Med, I-28100 Novara, Italy.
   [Varalda, Marco; Venetucci, Jacopo; Garro, Giulia; Bettio, Valentina; Capello, Daniela] Univ Piemonte Orientale, UPO Biobank, I-28100 Novara, Italy.
   [Nikaj, Herald; Gentilli, Sergio] Univ Piemonte Orientale, Gen Surg Div, AOU Maggiore Car, I-28100 Novara, Italy.
   [Valente, Guido] Osped St Andrea, Pathol Unity, I-13100 Vercelli, Italy.
   [Gentilli, Sergio] Univ Piemonte Orientale, Dept Hlth Sci, I-28100 Novara, Italy.
C3 University of Eastern Piedmont Amedeo Avogadro; University of Eastern
   Piedmont Amedeo Avogadro; University of Eastern Piedmont Amedeo
   Avogadro; University of Eastern Piedmont Amedeo Avogadro
RP Varalda, M (corresponding author), Univ Piemonte Orientale, Ctr Excellence Aging Sci, Dept Translat Med, I-28100 Novara, Italy.; Varalda, M (corresponding author), Univ Piemonte Orientale, UPO Biobank, I-28100 Novara, Italy.
EM marco.varalda@uniupo.it; jacopo.venetucci@uniupo.it;
   20027483@studenti.uniupo.it; 20041555@studenti.uniupo.it;
   giulia.garro@uniupo.it; 20047723@studenti.uniupo.it;
   valentina.bettio@med.uniupo.it; paolo.marzullo@med.uniupo.it;
   annamaria.antona@uniupo.it; guido.valente@med.uniupo.it;
   sergio.gentilli@med.uniupo.it; daniela.capello@med.uniupo.it
RI Bettio, Valentina/AFT-9834-2022; Antona, Annamaria/ISS-2899-2023;
   Marzullo, Paolo/K-6371-2016; Capello, Daniela/J-4110-2012
OI Varalda, Marco/0009-0001-8319-2057; Marzullo, Paolo/0000-0003-3215-5747;
   Venetucci, Jacopo/0009-0006-0191-1959; KANKARA, CHAITANYA
   REDDY/0009-0001-9820-8250; Capello, Daniela/0000-0001-9157-8753; Garro,
   Giulia/0009-0002-2611-5327
FU MUR-M4C2 1.3 of PNRR [MUR-M4C2 1.3, PE0000015]; Italian Ministry of
   University and Research (MUR) program [2023-2027, P2022E3BTH-CUP
   C53D23007600001]
FX This research was funded by the project AGE-IT, which received funding
   from the MUR-M4C2 1.3 of PNRR under grant agreement no. PE0000015. This
   study was (partially) funded by the Italian Ministry of University and
   Research (MUR) program, "Departments of Excellence 2023-2027", the AGING
   Project-Department of Translational Medicine, University of Piemonte
   Orientale, and is part of the project, P2022E3BTH-CUP C53D23007600001,
   which received funding from NextGeneration EU-MUR M4C2-PRIN 2022 PNRR.
CR Aldossary HS, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21176012
   Alrob OA, 2019, MEDICINA-LITHUANIA, V55, DOI 10.3390/medicina55070320
   Baldanzi G, 2016, FRONT CELL DEV BIOL, V4, DOI 10.3389/fcell.2016.00140
   Baptista LS, 2015, WORLD J STEM CELLS, V7, P165, DOI 10.4252/wjsc.v7.i1.165
   Barbagallo I, 2017, EXP BIOL MED, V242, P1079, DOI 10.1177/1535370216681552
   Barrow-McGee R, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms11942
   Beck GR, 2003, J BIOL CHEM, V278, P41921, DOI 10.1074/jbc.M304470200
   Bellini L, 2015, EXPERT OPIN THER TAR, V19, P1037, DOI 10.1517/14728222.2015.1028359
   Bernardo M, 2021, ADV THER, V38, P2491, DOI 10.1007/s12325-021-01689-8
   BOLLAG GE, 1986, P NATL ACAD SCI USA, V83, P5822, DOI 10.1073/pnas.83.16.5822
   Brandenburg LO, 2014, MEMBRANES, V4, P302, DOI 10.3390/membranes4030302
   Breiden B, 2020, BIOL CHEM, V401, P31, DOI 10.1515/hsz-2019-0270
   Bruntz RC, 2014, PHARMACOL REV, V66, P1033, DOI 10.1124/pr.114.009217
   Bymaster FP, 1996, NEUROPSYCHOPHARMACOL, V14, P87, DOI 10.1016/0893-133X(94)00129-N
   Cai JJ, 2009, BBA-MOL CELL BIOL L, V1791, P942, DOI 10.1016/j.bbalip.2009.02.010
   CARPENTIER JL, 1993, J CELL BIOL, V122, P1243, DOI 10.1083/jcb.122.6.1243
   Cen HH, 2022, FASEB J, V36, DOI 10.1096/fj.202100497RR
   Chait A, 2020, FRONT CARDIOVASC MED, V7, DOI 10.3389/fcvm.2020.00022
   Chen TC, 2017, SCI SIGNAL, V10, DOI 10.1126/scisignal.aai7905
   Chen W, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0121890
   Chen WY, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0179424
   Chen X, 2023, AGING CELL, V22, DOI 10.1111/acel.14003
   Chen Y, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20205007
   Cho J, 2018, AM J STEM CELLS, V7, P82
   Cignarelli A, 2016, NUTR METAB CARDIOVAS, V26, P333, DOI 10.1016/j.numecd.2015.11.010
   Cipriano R, 2014, ONCOGENE, V33, P3298, DOI 10.1038/onc.2013.293
   Coba MP, 2004, J ENDOCRINOL, V182, P433, DOI 10.1677/joe.0.1820433
   Copper MP, 2003, ARCH OTOLARYNGOL, V129, P709, DOI 10.1001/archotol.129.7.709
   Daniel JA, 2015, TRAFFIC, V16, P635, DOI 10.1111/tra.12272
   de Girolamo G, 2024, PLOS ONE, V19, DOI 10.1371/journal.pone.0298161
   del Campo A, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00144
   del Puerto A, 2012, J CELL SCI, V125, P176, DOI 10.1242/jcs.091736
   Deng T, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms15725
   Ferreira V, 2020, BBA-MOL CELL BIOL L, V1865, DOI 10.1016/j.bbalip.2019.158534
   Fijany A, 2019, MOL BIOL REP, V46, P1459, DOI 10.1007/s11033-018-4516-x
   Frasca D, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01745
   Gao XL, 2019, FRONT MOL NEUROSCI, V12, DOI 10.3389/fnmol.2019.00291
   Grajales D, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8111336
   GRAKO KA, 1992, ENDOCRINOLOGY, V130, P3441, DOI 10.1210/en.130.6.3441
   Gramaglia C, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00621
   Grundy SM, 2015, EUR J CLIN INVEST, V45, P1209, DOI 10.1111/eci.12519
   Hall C, 2020, EXP MOL MED, V52, P911
   Halls ML, 2011, CSH PERSPECT BIOL, V3, DOI 10.1101/cshperspect.a004143
   Hammarstedt A, 2018, PHYSIOL REV, V98, P1911, DOI 10.1152/physrev.00034.2017
   Hayden MR, 2023, MEDICINA-LITHUANIA, V59, DOI 10.3390/medicina59030561
   Hong Yang, 2018, F1000Res, V7, DOI 10.12688/f1000research.14427.1
   Hotamisligil GS, 2017, NATURE, V542, P177, DOI 10.1038/nature21363
   Hu M, 2020, FRONT ONCOL, V10, DOI 10.3389/fonc.2020.605361
   Hu YY, 2022, FRONT PHYSIOL, V13, DOI 10.3389/fphys.2022.803445
   Jatoi A, 2015, ONCOLOGY-BASEL, V88, P208, DOI 10.1159/000369257
   Joshi DM, 2021, BIOMED PHYS ENG EXPR, V7, DOI 10.1088/2057-1976/ac182e
   Kim H, 2015, CELL TRANSPLANT, V24, P1571, DOI 10.3727/096368914X682792
   Kim SH, 2018, PROG NEURO-PSYCHOPH, V81, P96, DOI 10.1016/j.pnpbp.2017.10.012
   Kuckuck S, 2024, J INTERN MED, V295, P2, DOI 10.1111/joim.13739
   Le TL, 2002, AM J PHYSIOL-CELL PH, V283, pC489, DOI 10.1152/ajpcell.00566.2001
   Lee S, 2008, ENDOCRINOLOGY, V149, P2451, DOI 10.1210/en.2007-1595
   Li H, 2016, ONCOTARGET, V7, P3548, DOI 10.18632/oncotarget.6516
   Li HQ, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-36930-y
   Li X, 2018, J ALLERGY CLIN IMMUN, V141, P1634, DOI 10.1016/j.jaci.2017.08.017
   Li Y, 2016, NAT CELL BIOL, V18, P1065, DOI 10.1038/ncb3407
   Li Z, 2015, EXP CELL RES, V331, P257, DOI 10.1016/j.yexcr.2014.12.021
   Liu JC, 2022, MEDICINE, V101, DOI 10.1097/MD.0000000000029775
   Liu TX, 2023, BMC PSYCHIATRY, V23, DOI 10.1186/s12888-023-05078-z
   Liu X, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.794298
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   Luo LP, 2016, J ENDOCRINOL, V231, pR77, DOI 10.1530/JOE-16-0211
   Madhira SL, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048061
   Makary S, 2023, EGYPT J NEUROL PSYCH, V59, DOI 10.1186/s41983-023-00612-y
   Malindisa E, 2023, BMC ENDOCR DISORD, V23, DOI 10.1186/s12902-023-01340-3
   Marketou M, 2017, CURR HYPERTENS REP, V19, DOI 10.1007/s11906-017-0716-3
   Martina JA, 2018, J BIOL CHEM, V293, P12525, DOI 10.1074/jbc.RA118.003471
   Mauri MC, 2004, SCHIZOPHR RES, V66, P197, DOI 10.1016/S0920-9964(03)00159-2
   Mayle KM, 2012, BBA-GEN SUBJECTS, V1820, P264, DOI 10.1016/j.bbagen.2011.09.009
   McKee A.M., 2000, OBESITY ELDERLY
   Mizunoe Y, 2017, AUTOPHAGY, V13, P642, DOI 10.1080/15548627.2016.1274850
   Mondal M., 2023, medRxiv
   Moore TJ, 2017, DRUG SAFETY, V40, P3, DOI 10.1007/s40264-016-0475-0
   Moreira A, 2017, J MOL ENDOCRINOL, V59, pR109, DOI 10.1530/JME-17-0117
   Muehlbacher M, 2012, CHEMMEDCHEM, V7, P1925, DOI 10.1002/cmdc.201200306
   Muñoz MC, 2009, J ENDOCRINOL, V201, P185, DOI 10.1677/JOE-08-0276
   Ong WK, 2014, STEM CELL REP, V2, P171, DOI 10.1016/j.stemcr.2014.01.002
   Onono FO, 2020, HANDB EXP PHARMACOL, V259, P204, DOI 10.1007/164_2019_320
   Panariello F, 2012, J OBES, V2012, DOI 10.1155/2012/572848
   Patergnani S, 2021, P NATL ACAD SCI USA, V118, DOI 10.1073/pnas.2020078118
   Peng QM, 2021, EUR J PHARMACOL, V891, DOI 10.1016/j.ejphar.2020.173706
   Pérez LM, 2016, J PHYSIOL-LONDON, V594, P3187, DOI 10.1113/JP271691
   Pileggi A, 2012, DIABETES, V61, P1355, DOI 10.2337/db12-0355
   Powell DJ, 2003, MOL CELL BIOL, V23, P7794, DOI 10.1128/MCB.23.21.7794-7808.2003
   Pozzi M, 2024, TRANSL PSYCHIAT, V14, DOI 10.1038/s41398-023-02686-x
   Pringsheim Tamara, 2014, CMAJ Open, V2, pE225, DOI 10.9778/cmajo.20140009
   Rakitin A, 2016, SEIZURE-EUR J EPILEP, V38, P11, DOI 10.1016/j.seizure.2016.03.008
   Rappaport J, 2015, MOL PHARMACEUT, V12, P1366, DOI 10.1021/mp5005959
   Rappaport J, 2014, MOL PHARMACEUT, V11, P2887, DOI 10.1021/mp500241y
   Rashid HO, 2015, AUTOPHAGY, V11, P1956, DOI 10.1080/15548627.2015.1091141
   Regmi S, 2019, EUR J CELL BIOL, V98, DOI 10.1016/j.ejcb.2019.04.002
   Regufe Virginia M G, 2020, Porto Biomed J, V5, pe101, DOI 10.1097/j.pbj.0000000000000101
   Riordan HJ, 2011, AM HEALTH DRUG BENEF, V4, P292
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Rojo LE, 2015, PHARMACOL RES, V101, P74, DOI 10.1016/j.phrs.2015.07.022
   Sacher J, 2008, NEUROPSYCHOPHARMACOL, V33, P1633, DOI 10.1038/sj.npp.1301541
   Saetang J, 2018, MOL MED REP, V17, P1403, DOI 10.3892/mmr.2017.8038
   Santillana N, 2023, NUTRIENTS, V15, DOI 10.3390/nu15071722
   Sarsenbayeva A, 2019, PSYCHONEUROENDOCRINO, V110, DOI 10.1016/j.psyneuen.2019.104445
   Schlam D, 2013, J BIOL CHEM, V288, P23090, DOI 10.1074/jbc.M113.457606
   Schoettl T, 2018, J EXP BIOL, V221, DOI 10.1242/jeb.162958
   Schubert M, 2004, P NATL ACAD SCI USA, V101, P3100, DOI 10.1073/pnas.0308724101
   Schulman IH, 2018, FRONT NUTR, V5, DOI 10.3389/fnut.2018.00108
   Scott SA, 2013, J BIOL CHEM, V288, P20477, DOI 10.1074/jbc.M113.451708
   Serrano-López EM, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms232214023
   Shi YF, 2018, NAT REV NEPHROL, V14, P493, DOI 10.1038/s41581-018-0023-5
   Siddiqi AR, 2000, BBA-MOL CELL RES, V1497, P103, DOI 10.1016/S0167-4889(00)00049-5
   Sommerfeld MR, 2004, BIOCHEMISTRY-US, V43, P5888, DOI 10.1021/bi049640v
   Song TT, 2021, EUR REV MED PHARMACO, V25, P1641, DOI 10.26355/eurrev_202102_24875
   Sontag E, 1997, EMBO J, V16, P5662, DOI 10.1093/emboj/16.18.5662
   Stretton C, 2010, AM J PHYSIOL-ENDOC M, V299, pE402, DOI 10.1152/ajpendo.00171.2010
   Tang Y, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0163324
   Tao HY, 2016, STEM CELLS INT, V2016, DOI 10.1155/2016/1314709
   Thellung S, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20040901
   Tisdale EJ, 2003, J BIOL CHEM, V278, P38015, DOI 10.1074/jbc.M305381200
   Townsend LK, 2018, PSYCHONEUROENDOCRINO, V88, P121, DOI 10.1016/j.psyneuen.2017.12.004
   Unamuno X, 2018, EUR J CLIN INVEST, V48, DOI 10.1111/eci.12997
   Varalda M, 2020, FRONT ONCOL, V10, DOI 10.3389/fonc.2020.562196
   Vaugeois JM, 2020, PSYCHIAT RES, V291, DOI 10.1016/j.psychres.2020.113220
   Velnati S, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9010045
   Vestri HS, 2007, NEUROPSYCHOPHARMACOL, V32, P765, DOI 10.1038/sj.npp.1301142
   Vranic M, 2023, MOL CELL ENDOCRINOL, V561, DOI 10.1016/j.mce.2022.111828
   Vucicevic L, 2018, CELL STRESS, V2, P282, DOI 10.15698/cst2018.11.161
   Wajchenberg BL, 2000, ENDOCR REV, V21, P697, DOI 10.1210/er.21.6.697
   Wang FJ, 2018, TRAFFIC, V19, P918, DOI 10.1111/tra.12613
   Weernink PAO, 2007, BBA-BIOMEMBRANES, V1768, P888, DOI 10.1016/j.bbamem.2006.09.012
   Werner ED, 2004, J BIOL CHEM, V279, P35298, DOI 10.1074/jbc.M405203200
   Weston-Green K, 2018, J BIOMED SCI, V25, DOI 10.1186/s12929-018-0437-1
   World Health Organization, 2015, AG HLTH
   Xiao HL, 2013, CELL MOL LIFE SCI, V70, P3057, DOI 10.1007/s00018-012-1192-1
   Ye WY, 2011, PATIENT PREFER ADHER, V5, P611, DOI 10.2147/PPA.S26002
   Yun HR, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21093289
   Zang LG, 2020, ADIPOCYTE, V9, P24, DOI 10.1080/21623945.2020.1721235
   Zhang DY, 2020, AM J TRANSL RES, V12, P3078
   Zhang F, 2014, MOL CELL BIOL, V34, P84, DOI 10.1128/MCB.00987-13
   Zhang XL, 2018, BIOCHEM PHARMACOL, V158, P114, DOI 10.1016/j.bcp.2018.10.001
   Zhang YJ, 2019, MOL BRAIN, V12, DOI 10.1186/s13041-019-0445-4
   Zhao JF, 2024, ISCIENCE, V27, DOI 10.1016/j.isci.2024.110432
   Zhong L, 2021, FRONT CELL NEUROSCI, V15, DOI 10.3389/fncel.2021.726605
   Zwick RK, 2018, CELL METAB, V27, P68, DOI 10.1016/j.cmet.2017.12.002
NR 144
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD DEC
PY 2024
VL 13
IS 24
AR 2084
DI 10.3390/cells13242084
PG 30
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA Q3P8F
UT WOS:001383852700001
PM 39768174
OA gold
DA 2025-06-11
ER

PT J
AU Solís, CB
   Fantin, R
   Kelly-Irving, M
   Delpierre, C
AF Solis, Cristina Barboza
   Fantin, Romain
   Kelly-Irving, Michelle
   Delpierre, Cyrille
TI Physiological wear-and-tear and later subjective health in mid-life:
   Findings from the 1958 British birth cohort
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Allostatic load; Subjective health; Embodiment; Biomarkers; Social
   gradient; Birth cohort
ID QUALITY-OF-LIFE; BODY-MASS INDEX; ALLOSTATIC LOAD; SOCIOECONOMIC
   POSITION; METABOLIC SYNDROME; BIOLOGICAL RISK; MORTALITY; PREDICTOR;
   MACARTHUR; OBESITY
AB Objective: Our body adapts continuously to environmental challenges and stressful conditions. Allostatic load (AL) is a concept that aims to capture the overall physiological wear-and-tear of the body triggered by the repeated activation of compensatory physiological mechanisms as a response to chronic stress. Growing evidence has shown a link between AL and later health decline, morbidity and mortality. However, due to the global physiological effect captured by the AL concept, it is particularly pertinent to examine its association with subsequent health by taking a broad definition of the latter. We examined the association between AL at 44 years and general health as measured by a latent multidimensional measure of subjective health at 50 years integrating sleep patterns, physical and mental health.
   Methods: AL was constructed using 14 biomarkers representing four physiological systems on 7573 members of the 1958 British birth cohort. Health status was captured using self-reported information about subjective health and summarized using a principal component analysis including: seven dimensions of the SF-36 questionnaire of health-related quality of life, the sleep subscale of the Medical Outcomes Study characterizing quality of sleep patterns, and a malaise inventory score detecting depressive symptoms.
   Results: Higher AL score was gradually associated with worse subjective health, after taking into account classic confounders.
   Conclusions: Using a physiological index to grasp how the environment can "get under the skin" leading to poor health is of great interest, permitting a better understanding of life course origins of disease and social gradients in health. (C) 2016 The Authors. Published by Elsevier Ltd.
C1 [Solis, Cristina Barboza; Fantin, Romain; Kelly-Irving, Michelle; Delpierre, Cyrille] Univ Toulouse III Paul Sabatier, INSERM, LEASP, UMR 1027, Toulouse, France.
   [Solis, Cristina Barboza] Univ Costa Rica, San Jose 2060, Costa Rica.
C3 Universite de Toulouse; Universite Toulouse III - Paul Sabatier;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universidad Costa Rica
RP Solís, CB (corresponding author), Univ Paul Sabatier, INSERM, UMR 1027, Fac Med, 37 Allees Jules Guesde, F-31000 Toulouse, France.
EM cristina.barboza-solis@inserm.fr
RI Fantin, Romain/AAJ-2500-2020; Kelly-Irving, Michelle/G-3151-2010;
   Barboza Solis, Cristina/AAB-9922-2020
OI Fantin, Romain/0000-0003-2906-3438; delpierre,
   cyrille/0000-0002-0831-080X; Kelly-Irving, Michelle/0000-0001-5749-4791;
   Barboza Solis, Cristina/0000-0002-7208-7374
FU ESRC [ES/M001660/1] Funding Source: UKRI
CR Atherton K, 2008, J EPIDEMIOL COMMUN H, V62, P216, DOI 10.1136/jech.2006.058966
   Beckie TM, 2012, BIOL RES NURS, V14, P311, DOI 10.1177/1099800412455688
   Butland BK, 2008, EUR RESPIR J, V32, P77, DOI 10.1183/09031936.00077207
   Calle EE, 1999, NEW ENGL J MED, V341, P1097, DOI 10.1056/NEJM199910073411501
   Carlson ED, 2005, RES NURS HEALTH, V28, P306, DOI 10.1002/nur.20084
   Carroll JE, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0118467
   Chatzitheochari S., 2013, WORKING PAPER
   de Gonzalez AB, 2010, NEW ENGL J MED, V363, P2211, DOI 10.1056/NEJMoa1000367
   Delpierre C., 2016, ORIGINS HLTH INEQUAL, V7, P25
   Dowd JB, 2009, INT J EPIDEMIOL, V38, P1297, DOI 10.1093/ije/dyp277
   Ferrucci L, 2007, ARCH INTERN MED, V167, P750, DOI 10.1001/archinte.167.8.750
   Ford ES, 2001, OBES RES, V9, P21, DOI 10.1038/oby.2001.4
   Galobardes B, 2006, J EPIDEMIOL COMMUN H, V60, P95, DOI 10.1136/jech.2004.028092
   Goldman N, 2004, J WOMENS HEALTH, V13, P393, DOI 10.1089/154099904323087088
   Gruenewald TL, 2006, P NATL ACAD SCI USA, V103, P14158, DOI 10.1073/pnas.0606215103
   Gruenewald TL, 2012, SOC SCI MED, V74, P75, DOI 10.1016/j.socscimed.2011.09.037
   Gustafsson PE, 2012, ANN BEHAV MED, V43, P117, DOI 10.1007/s12160-011-9309-6
   Gustafsson PE, 2011, J EPIDEMIOL COMMUN H, V65, P986, DOI 10.1136/jech.2010.108332
   Hays RD, 2005, SLEEP MED, V6, P41, DOI 10.1016/j.sleep.2004.07.006
   House of Commons Science and Technology Committee, 2012, ALC GUID 11 SESS 201, P1
   Hyland ME, 2014, BRAIN BEHAV IMMUN, V40, P104, DOI 10.1016/j.bbi.2014.02.018
   Juster RP, 2011, DEV PSYCHOPATHOL, V23, P725, DOI 10.1017/S0954579411000289
   Juster RP, 2010, NEUROSCI BIOBEHAV R, V35, P2, DOI 10.1016/j.neubiorev.2009.10.002
   Kaplan MS, 2007, QUAL LIFE RES, V16, P1539, DOI 10.1007/s11136-007-9256-7
   Karlamangla AS, 2006, PSYCHOSOM MED, V68, P500, DOI 10.1097/01.psy.0000221270.93985.82
   Karlamangla AS, 2002, J CLIN EPIDEMIOL, V55, P696, DOI 10.1016/S0895-4356(02)00399-2
   Krieger N, 2005, J EPIDEMIOL COMMUN H, V59, P350, DOI 10.1136/jech.2004.024562
   Kumari M, 2013, PSYCHOL MED, V43, P633, DOI 10.1017/S0033291712001353
   Kumari M, 2008, ANN EPIDEMIOL, V18, P664, DOI 10.1016/j.annepidem.2008.03.001
   Kumari M, 2011, J CLIN ENDOCR METAB, V96, P1478, DOI 10.1210/jc.2010-2137
   Lock M, 2001, AM J HUM BIOL, V13, P494, DOI 10.1002/ajhb.1081
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   McEwen BS, 1999, ANN NY ACAD SCI, V896, P30, DOI 10.1111/j.1749-6632.1999.tb08103.x
   McEwen BS, 2003, HORM BEHAV, V43, P2, DOI 10.1016/S0018-506X(02)00024-7
   MCEWEN BS, 1993, ARCH INTERN MED, V153, P2093, DOI 10.1001/archinte.153.18.2093
   McMillen IC, 2005, PHYSIOL REV, V85, P571, DOI 10.1152/physrev.00053.2003
   Miyamoto Y, 2013, BRAIN BEHAV IMMUN, V34, P79, DOI 10.1016/j.bbi.2013.07.173
   Otero-Rodríguez A, 2010, QUAL LIFE RES, V19, P15, DOI 10.1007/s11136-009-9561-4
   Power C, 2006, INT J EPIDEMIOL, V35, P34, DOI 10.1093/ije/dyi183
   Power C, 1998, LANCET, V351, P1009, DOI 10.1016/S0140-6736(97)11082-0
   Robertson T, 2015, BRAIN BEHAV IMMUN, V45, P41, DOI 10.1016/j.bbi.2014.10.005
   Robertson T, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-184
   Rodgers B, 1999, SOC PSYCH PSYCH EPID, V34, P333, DOI 10.1007/s001270050153
   Rodríguez-Artalejo F, 2005, ARCH INTERN MED, V165, P1274, DOI 10.1001/archinte.165.11.1274
   Rutter M., 1970, Education, health and behaviour
   Ryff C.D., 2014, INCREASING PSYCHOL W
   Seeman TE, 1997, ARCH INTERN MED, V157, P2259
   Seeman TE, 2001, P NATL ACAD SCI USA, V98, P4770, DOI 10.1073/pnas.081072698
   Seeman T, 2010, ANN NY ACAD SCI, V1186, P223, DOI 10.1111/j.1749-6632.2009.05341.x
   Solís CB, 2015, P NATL ACAD SCI USA, V112, pE738, DOI 10.1073/pnas.1417325112
   Spiegel K, 1999, LANCET, V354, P1435, DOI 10.1016/S0140-6736(99)01376-8
   Sterling P., 2004, Principles of Allostasis: Optimal design, P17, DOI 10.1017/CBO9781316257081.004
   Sterling P, 2012, PHYSIOL BEHAV, V106, P5, DOI 10.1016/j.physbeh.2011.06.004
   Stewart A, 1992, Measuring Functioning and Well-being: The Medical Outcomes Study Approach, P235
   Szanton SL, 2005, BIOL RES NURS, V7, P7, DOI 10.1177/1099800405278216
   Taft C, 2001, QUAL LIFE RES, V10, P395, DOI 10.1023/A:1012552211996
   Testa MA, 1996, NEW ENGL J MED, V334, P835, DOI 10.1056/NEJM199603283341306
   Tsai SY, 2007, EUR J EPIDEMIOL, V22, P19, DOI 10.1007/s10654-006-9092-z
   Viala-Danten M, 2008, HEALTH QUAL LIFE OUT, V6, DOI 10.1186/1477-7525-6-113
   VOGT T, 1994, AM J PUBLIC HEALTH, V84, P227, DOI 10.2105/AJPH.84.2.227
   Ware JE, 2000, SPINE, V25, P3130, DOI 10.1097/00007632-200012150-00008
   Yang Y, 2011, J GERONTOL A-BIOL, V66, P493, DOI 10.1093/gerona/glr003
NR 62
TC 28
Z9 32
U1 0
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD DEC
PY 2016
VL 74
BP 24
EP 33
DI 10.1016/j.psyneuen.2016.08.018
PG 10
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA EB6VW
UT WOS:000387524700004
PM 27567118
OA hybrid
DA 2025-06-11
ER

PT J
AU Froogh, G
   Kandhi, S
   Duvvi, R
   Le, YC
   Weng, Z
   Alruwaili, N
   Ashe, JO
   Sun, D
   Huang, A
AF Froogh, Ghezal
   Kandhi, Sharath
   Duvvi, Roopa
   Le, Yicong
   Weng, Zan
   Alruwaili, Norah
   Ashe, Jonathan O.
   Sun, Dong
   Huang, An
TI The contribution of chymase-dependent formation of ANG II to cardiac
   dysfunction in metabolic syndrome of young rats: roles of fructose and
   EETs
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE angiotensin II; chymase; high fructose; metabolic syndrome; soluble
   epoxide hydrolase
ID SOLUBLE EPOXIDE HYDROLASE; ANGIOTENSIN-CONVERTING ENZYME-2; DIETARY
   FRUCTOSE; NADPH OXIDASE; INHIBITION; MEDIATORS; PREVENTS; SYSTEM;
   MUSCLE; ACID
AB The roles of ACE-independent ANG II production via chymase and therapeutic potential of epoxyeicosatrienoic acids (EETs) in fructose-induced metabolic syndrome (MetS) in the adolescent population remain elusive. Thus we tested the hypothesis that a high-fructose diet (HFD) in young rats elicits chymase-dependent increases in ANG II production and oxidative stress, responses that are reversible by 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), an inhibitor of soluble epoxide hydrolase (sEH) that metabolizes EETs. Three groups of weanling rats (21-day-old) were fed a normal diet, 60% HFD, and HFD with TPPU, respectively, for 30 days. HFD rats developed MetS, characterized by hyperglycemia, hyperinsulinemia, and hypertension and associated with decreases in cardiac output and stroke volume and loss of nitric oxide (NO) modulation of myocardial oxygen consumption; all impairments were normalized by TPPU that significantly elevated circulating 11,12-EET, a major cardiac EET isoform. In the presence of comparable cardiac angiotensin-converting enzyme (ACE) expression/activity among the three groups, HFD rats exhibited significantly greater chymase-dependent ANG II formation in hearts, as indicated by an augmented cardiac chymase content as a function of enhanced mast cell degranulation. The enhanced chymase-dependent ANG II production was paralleled with increases in ANG II type 1 receptor (AT1R) expression and NADPH oxidase (Nox)-induced superoxide, alterations that were significantly reversed by TPPU. Conversely, HFD-induced downregulation of cardiac ACE2, followed by a lower Ang-(1-7) level displayed in an TPPU-irreversible manner. In conclusion, HFD-driven adverse chymase/ANG II/Nox/superoxide signaling in young rats was prevented by inhibition of sEH via, at least in part, an EET-mediated stabilization of mast cells, highlighting chymase and sEH as therapeutic targets during treatment of MetS.
   NEW & NOTEWORTHY As the highest fructose consumers, the adolescent population is highly susceptible to the metabolic syndrome, where increases in mast cell chymase-dependent formation of ANG II, ensued by cardiometabolic dysfunction, are reversible in response to inhibition of soluble epoxide hydrolase (sEH). This study highlights chymase and sEH as therapeutic targets and unravels novel avenues for the development of optimal strategies for young patients with fructose-induced metabolic syndrome.
C1 [Froogh, Ghezal; Kandhi, Sharath; Duvvi, Roopa; Le, Yicong; Weng, Zan; Alruwaili, Norah; Ashe, Jonathan O.; Sun, Dong; Huang, An] New York Med Coll, Dept Physiol, Valhalla, NY 10595 USA.
C3 New York Medical College
RP Huang, A (corresponding author), New York Med Coll, Dept Physiol, Valhalla, NY 10595 USA.
EM an_huang@nymc.edu
RI Le, Yi/JUF-6980-2023
FU National Heart, Lung, and Blood Institute [HL-070653, HL-129797,
   HL-144528]
FX This work was supported by National Heart, Lung, and Blood Institute
   Grants HL-070653, HL-129797, and HL-144528.
CR Abdelmalek MF, 2012, HEPATOLOGY, V56, P952, DOI 10.1002/hep.25741
   Ahmad S, 2016, BIOCHEM BIOPH RES CO, V478, P559, DOI 10.1016/j.bbrc.2016.07.100
   Ai D, 2007, P NATL ACAD SCI USA, V104, P9018, DOI 10.1073/pnas.0703229104
   Chaudhary KR, 2009, IUBMB LIFE, V61, P954, DOI 10.1002/iub.241
   Chelombitko MA, 2016, BIOCHEMISTRY-MOSCOW+, V81, P1564, DOI 10.1134/S000629791612018X
   Crackower MA, 2002, NATURE, V417, P822, DOI 10.1038/nature00786
   Deng YM, 2010, J MOL CELL CARDIOL, V48, P331, DOI 10.1016/j.yjmcc.2009.10.022
   Ferrario CM, 2006, AM J CARDIOL, V98, P121, DOI 10.1016/j.amjcard.2006.01.059
   Ferrario CM, 2016, AM J PHYSIOL-HEART C, V311, pH404, DOI 10.1152/ajpheart.00219.2016
   Froogh G, 2017, AM J PHYSIOL-HEART C, V312, pH223, DOI 10.1152/ajpheart.00534.2016
   GRIENDLING KK, 1994, CIRC RES, V74, P1141, DOI 10.1161/01.RES.74.6.1141
   Hanna IR, 2002, ANTIOXID REDOX SIGN, V4, P899, DOI 10.1089/152308602762197443
   Hu J, 2017, NATURE, V552, P248, DOI 10.1038/nature25013
   Hu ZQ, 1997, BLOOD, V89, P526, DOI 10.1182/blood.V89.2.526
   Huang A, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01222
   Huynh M, 2008, OBESITY, V16, P1755, DOI 10.1038/oby.2008.268
   Ihara M, 1999, HYPERTENSION, V33, P1399, DOI 10.1161/01.HYP.33.6.1399
   Imig JD, 2002, HYPERTENSION, V39, P690, DOI 10.1161/hy0202.103788
   Imig JD, 2012, EXP BIOL MED, V237, P1402, DOI 10.1258/ebm.2012.012225
   Imig JD, 2009, NAT REV DRUG DISCOV, V8, P794, DOI 10.1038/nrd2875
   Katragadda D, 2009, J MOL CELL CARDIOL, V46, P867, DOI 10.1016/j.yjmcc.2009.02.028
   Li ZY, 2015, PHOTOCH PHOTOBIO SCI, V14, P414, DOI 10.1039/c4pp00304g
   Lim JS, 2010, NAT REV GASTRO HEPAT, V7, P251, DOI 10.1038/nrgastro.2010.41
   Lorenz JN, 2010, AM J PHYSIOL-RENAL, V298, pF35, DOI 10.1152/ajprenal.00641.2009
   Maayah ZH, 2019, J CARDIOVASC PHARM, V74, P235, DOI 10.1097/FJC.0000000000000707
   Mahmoud AM, 2017, REDOX BIOL, V13, P288, DOI 10.1016/j.redox.2017.06.001
   Melendez Giselle C., 2010, Toxicological and Environmental Chemistry, V92, P1293, DOI 10.1080/02772240903306409
   Min D, 2009, J IMMUNOL, V182
   Murdoch CE, 2011, BASIC RES CARDIOL, V106, P527, DOI 10.1007/s00395-011-0179-7
   Nishida M, 2011, NITRIC OXIDE-BIOL CH, V25, P112, DOI 10.1016/j.niox.2010.10.003
   Park S, 2013, HYPERTENSION, V61, P465, DOI 10.1161/HYPERTENSIONAHA.111.202424
   Park S, 2010, AM J PHYSIOL-RENAL, V298, pF37, DOI 10.1152/ajprenal.00519.2009
   Patel VB, 2016, CIRC RES, V118, P1313, DOI 10.1161/CIRCRESAHA.116.307708
   Patel VB, 2015, J MOL MED, V93, P1003, DOI 10.1007/s00109-015-1285-z
   Patel VB, 2012, CIRC RES, V110, P1322, DOI 10.1161/CIRCRESAHA.112.268029
   Roman RJ, 2002, PHYSIOL REV, V82, P131, DOI 10.1152/physrev.00021.2001
   Stanhope KL, 2015, AM J CLIN NUTR, V101, P1144, DOI 10.3945/ajcn.114.100461
   Sun A, 2017, J APPL PHYSIOL, V122, P368, DOI 10.1152/japplphysiol.00767.2016
   Sun D, 2014, AM J PHYSIOL-HEART C, V306, pH1146, DOI 10.1152/ajpheart.00920.2013
   Suzuki Y, 2005, CHEM IMMUNOL ALLERGY, V87, P32, DOI 10.1159/000087569
   Tran LT, 2009, MOL CELL BIOCHEM, V332, P145, DOI 10.1007/s11010-009-0184-4
   Vos Miriam B, 2008, Medscape J Med, V10, P160
   Xu XZ, 2010, DIABETES, V59, P997, DOI 10.2337/db09-1241
   Yokota R, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01433
   Yu H, 2019, AM J PHYSIOL-LUNG C, V317, pL569, DOI 10.1152/ajplung.00080.2018
   Yu ZG, 2000, CIRC RES, V87, P992, DOI 10.1161/01.RES.87.11.992
   Zhang DM, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040335
   Zhang M, 2016, MOL MED REP, V14, P121, DOI 10.3892/mmr.2016.5234
   2003, ARCH PHYSIOL BIOCHEM, V111, P17
NR 49
TC 12
Z9 12
U1 0
U2 0
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD APR
PY 2020
VL 318
IS 4
BP H985
EP H993
DI 10.1152/ajpheart.00633.2019
PG 9
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA LC4VH
UT WOS:000525323400015
PM 32167781
OA Green Published
DA 2025-06-11
ER

PT J
AU Vara-García, C
   Romero-Moreno, R
   Barrera-Caballero, S
   Pedroso-Chaparro, MD
   Jiménez-Gonzalo, L
   Olazarán, J
   Mausbach, B
   von Känel, R
   Losada-Baltar, A
AF Vara-Garcia, Carlos
   Romero-Moreno, Rosa
   Barrera-Caballero, Samara
   Pedroso-Chaparro, Maria del Sequeros
   Jimenez-Gonzalo, Lucia
   Olazaran, Javier
   Mausbach, Brent
   von Kanel, Roland
   Losada-Baltar, Andres
TI Associations Between Dysfunctional Thoughts, Leisure Activities, and
   IL-6 in Caregivers of Family Members With Dementia
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE caregivers; dementia; dysfunctional thoughts; inflammation; leisure; BMI
   = body mass index; BPSD = behavioral and psychological symptoms of
   dementia; HDL = high-density lipoprotein; IL-6=interleukin 6
ID CORONARY-HEART-DISEASE; CONFIRMATORY FACTOR-ANALYSIS; INSOMNIA SEVERITY
   INDEX; DEPRESSIVE SYMPTOMS; CHRONIC STRESS; ALZHEIMERS-DISEASE; PHYSICAL
   HEALTH; BLOOD-PRESSURE; INFLAMMATORY CYTOKINES; METABOLIC SYNDROME
AB ObjectiveDementia caregiving is associated with negative physical health consequences, including inflammation processes. The objective of this study was to analyze the associations between dysfunctional thoughts, frequency of leisure activities, and interleukin 6 (IL-6) in a sample of dementia family caregivers.MethodsOne hundred forty dementia caregivers participated in this cross-sectional study. The relationships among caregivers' dysfunctional thoughts, leisure activities, and IL-6 were adjusted for demographic characteristics, stressors, and physical and mental health indicators in a linear regression analysis.ResultsHigher levels of dysfunctional thoughts (t = -2.02, p = .045) were significantly associated with lower frequency of leisure activities. In turn, lower frequency of leisure activities was significantly associated with higher levels of IL-6 (t = -2.03, p = .045). Dysfunctional thoughts were no longer significantly associated with IL-6 levels when both dysfunctional thoughts and leisure activities were included in the same model (t = 1.78, p = .076). A significant indirect effect was found for the association between higher levels of dysfunctional thoughts and higher levels of IL-6 (standardized indirect effect = 0.036, bootstrap standard error = 0.026, 95% confidence interval = 0.0001-0.1000) through its association with fewer leisure activities.ConclusionsOur findings suggest that the direct effect of caregivers' dysfunctional thoughts on IL-6 may be mediated by the impact on caregivers' frequency of leisure activities. Results suggest that training caregivers in reducing dysfunctional thoughts to thereby increase leisure activities may be useful in reducing inflammation.
C1 [Vara-Garcia, Carlos; Romero-Moreno, Rosa; Barrera-Caballero, Samara; Jimenez-Gonzalo, Lucia; Losada-Baltar, Andres] Univ Rey Juan Carlos, Dept Psychol, Alcorcon, Spain.
   [Pedroso-Chaparro, Maria del Sequeros] Univ Autonoma Madrid, Dept Biol & Hlth Psychol, Madrid, Spain.
   [Olazaran, Javier] Hosp Gen Univ Gregorio Maranon, Dept Neurol, Madrid, Spain.
   [Mausbach, Brent] Univ Calif San Diego, Dept Psychiat, San Diego, CA USA.
   [von Kanel, Roland] Univ Zurich, Univ Hosp Zurich, Dept Consultat Liaison Psychiat & Psychosomat Med, Zurich, Switzerland.
C3 Universidad Rey Juan Carlos; Autonomous University of Madrid; General
   University Gregorio Maranon Hospital; University of California System;
   University of California San Diego; University of Zurich; University
   Zurich Hospital
RP Vara-García, C (corresponding author), Univ Rey Juan Carlos, Dept Psicol, Campus Alcorcon,Ave Atenas s-n, Madrid 28822, Spain.
EM carlos.vara@urjc.es; rosa.romero@urjc.es; samara.barrera@urjc.es;
   maria.pedroso@uam.es; lucia.jimenez@urjc.es; javier@mariawolff.es;
   bmausbach@health.ucsd.edu; Roland.VonKaenel@usz.ch;
   andres.losada@urjc.es
RI del Sequeros Pedroso-Chaparro, María/ACK-9895-2022; Jiménez Gonzalo,
   Lucía/GLV-3720-2022; Losada, Andres/C-8920-2011; von Kanel,
   Roland/B-1811-2019; Vara Garcia, Carlos/S-7534-2018; Romero Moreno,
   Rosa/G-3479-2011
OI Losada, Andres/0000-0002-3134-7133; Barrera Caballero,
   Samara/0000-0002-0987-3188; von Kanel, Roland/0000-0002-8929-5129;
   Olazaran, Javier/0000-0002-7320-128X; Jimenez-Gonzalo,
   Lucia/0000-0002-2305-3362; Vara Garcia, Carlos/0000-0002-5379-5770;
   Romero Moreno, Rosa/0000-0001-5454-3586; Pedroso-Chaparro, Maria del
   Sequeros/0000-0002-5224-9137
FU Spanish Ministry of Science and Innovation [PSI2015-65152-C2-1-R,
   PDI2019-106714RB-C21]; FPU grant from the Spanish Ministry of Education;
   Universidad Autonoma de Madrid; Universidad Rey Juan Carlos; US National
   Institutes of Health;  [R01 AG061941]
FX The preparation of this article was supported in part by grants from the
   Spanish Ministry of Science and Innovation under grants
   PSI2015-65152-C2-1-R and PDI2019-106714RB-C21. S.B.-C. was supported by
   an FPU grant FPU17/02548 from the Spanish Ministry of Education.
   M.d.S.P.-C. was supported by a predoctoral grant from the Universidad
   Autonoma de Madrid. L.J.-G. was supported by a predoctoral grant from
   the Universidad Rey Juan Carlos. B.M. was supported by the US National
   Institutes of Health via grant number R01 AG061941. The authors declare
   no conflict of interest.
CR Allen AP, 2017, NEUROSCI BIOBEHAV R, V73, P123, DOI 10.1016/j.neubiorev.2016.12.006
   BALAGUER I., 1993, REV PSICOLOG A DEPOR, V4, P39
   Barter P, 2007, NEW ENGL J MED, V357, P1301, DOI 10.1056/NEJMoa064278
   Capistrant BD, 2012, J EPIDEMIOL COMMUN H, V66, P951, DOI 10.1136/jech-2011-200040
   Chattillion EA, 2013, HEALTH PSYCHOL, V32, P793, DOI 10.1037/a0029412
   Danesh J, 2008, PLOS MED, V5, P600, DOI 10.1371/journal.pmed.0050078
   Frisdal E, 2011, J BIOL CHEM, V286, P30926, DOI 10.1074/jbc.M111.264325
   Gagnon C, 2013, J AM BOARD FAM MED, V26, P701, DOI 10.3122/jabfm.2013.06.130064
   Gouin JP, 2012, HEALTH PSYCHOL, V31, P264, DOI 10.1037/a0025536
   Gouin JP, 2008, NEUROIMMUNOMODULAT, V15, P251, DOI 10.1159/000156468
   Harmell AL, 2011, CURR PSYCHIAT REP, V13, P219, DOI 10.1007/s11920-011-0187-1
   Hayes A. F., 2017, INTRO MEDIATION MODE
   Helgeson V S, 1998, Pers Soc Psychol Rev, V2, P173, DOI 10.1207/s15327957pspr0203_2
   Holland JM, 2010, AGEING INT, V35, P109, DOI 10.1007/s12126-010-9057-0
   Huertas-Domingo C, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18094700
   Jiménez-Gonzalo L, 2021, SLEEP MED, V82, P65, DOI 10.1016/j.sleep.2021.03.036
   Kaptoge S, 2014, EUR HEART J, V35, P578, DOI 10.1093/eurheartj/eht367
   Kiecolt-Glaser JK, 2003, P NATL ACAD SCI USA, V100, P9090, DOI 10.1073/pnas.1531903100
   Kim JH, 2008, GERONTOLOGIST, V48, P287, DOI 10.1093/geront/48.3.287
   Knight BG, 2010, J GERONTOL B-PSYCHOL, V65, P5, DOI 10.1093/geronb/gbp096
   Lee S, 2003, AM J PUBLIC HEALTH, V93, P1939, DOI 10.2105/AJPH.93.11.1939
   Losada A., 2006, Psicologia Conductual, V14, P115
   Losada A., 2008, Ediciones Encuentro
   Losada A., 2006, ESTUDIO INTERVENCION, V1st, P216
   Losada A, 2015, J CONSULT CLIN PSYCH, V83, P760, DOI 10.1037/ccp0000028
   Losada A, 2012, SPAN J PSYCHOL, V15, P783, DOI 10.5209/rev_SJOP.2012.v15.n2.38890
   Losada A, 2011, INT J GERIATR PSYCH, V26, P1119, DOI 10.1002/gps.2648
   Lynam DR, 2006, ASSESSMENT, V13, P328, DOI 10.1177/1073191106290562
   García-Alberca JM, 2012, INT PSYCHOGERIATR, V24, P1325, DOI 10.1017/S1041610211002948
   Mausbach BT, 2007, HEALTH PSYCHOL, V26, P539, DOI 10.1037/0278-6133.26.5.539
   Mausbach BT, 2019, PSYCHOSOM MED, V81, P668, DOI 10.1097/PSY.0000000000000716
   Mausbach BT, 2017, PSYCHOSOM MED, V79, P735, DOI 10.1097/PSY.0000000000000497
   Mausbach BT, 2012, HEALTH PSYCHOL, V31, P433, DOI 10.1037/a0027783
   McNair DM, 1971, EITS Manual for the Profile of Mood States
   Mills PJ, 2009, BRAIN BEHAV IMMUN, V23, P605, DOI 10.1016/j.bbi.2008.09.014
   Moore RC, 2013, BEHAV RES THER, V51, P623, DOI 10.1016/j.brat.2013.07.005
   Nogales-González C, 2015, INT PSYCHOGERIATR, V27, P683, DOI 10.1017/S1041610214002476
   O'Neil A, 2018, CIRCULATION, V137, P854, DOI 10.1161/CIRCULATIONAHA.117.028595
   Pinquart M, 2007, J GERONTOL B-PSYCHOL, V62, pP126, DOI 10.1093/geronb/62.2.P126
   Potier F, 2018, AGING CLIN EXP RES, V30, P119, DOI 10.1007/s40520-017-0765-0
   Pucci G, 2017, PHARMACOL RES, V120, P34, DOI 10.1016/j.phrs.2017.03.008
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Ridker PM, 2021, CIRC RES, V128, P1728, DOI 10.1161/CIRCRESAHA.121.319077
   Rohleder N, 2019, PSYCHONEUROENDOCRINO, V105, P164, DOI 10.1016/j.psyneuen.2019.02.021
   Romero-Moreno R, 2014, AN PSICOL-SPAIN, V30, P878, DOI 10.6018/analesps.30.3.148381
   Roth DL, 2008, PSYCHOL AGING, V23, P567, DOI 10.1037/a0013287
   SABOGAL F, 1987, HISPANIC J BEHAV SCI, V9, P397, DOI 10.1177/07399863870094003
   Sansoni Julita, 2004, Int J Nurs Pract, V10, P93, DOI 10.1111/j.1440-172X.2003.00461.x
   Schulz R, 2020, ANNU REV PSYCHOL, V71, P635, DOI 10.1146/annurev-psych-010419-050754
   Shaw WS, 2003, J PSYCHOSOM RES, V54, P293, DOI 10.1016/S0022-3999(02)00412-9
   Soysal P, 2016, AGEING RES REV, V31, P1, DOI 10.1016/j.arr.2016.08.006
   Stephens MAP, 2001, J GERONTOL B-PSYCHOL, V56, pP24, DOI 10.1093/geronb/56.1.P24
   Sullivan KA, 2016, DEMENTIA-LONDON, V15, P1474, DOI 10.1177/1471301214553038
   TERI L, 1992, PSYCHOL AGING, V7, P622, DOI 10.1037/0882-7974.7.4.622
   Turnbull AV, 1999, PHYSIOL REV, V79, P1, DOI 10.1152/physrev.1999.79.1.1
   VANSNICK J, 1990, ANNU REV IMMUNOL, V8, P253, DOI 10.1146/annurev.immunol.8.1.253
   Vara-García C, 2021, CLIN SALUD, V32, P79, DOI 10.5093/clysa2020a33
   Vara-García C, 2022, INT PSYCHOGERIATR, V34, P275, DOI 10.1017/S1041610221000715
   Vitaliano PP, 2002, PSYCHOSOM MED, V64, P418, DOI 10.1097/00006842-200205000-00006
   Vollmer-Conna U, 2004, PSYCHOL MED, V34, P1289, DOI 10.1017/S0033291704001953
   von Känel R, 2008, GERONTOLOGY, V54, P131, DOI 10.1159/000113649
   von Känel R, 2006, J GERONTOL A-BIOL, V61, P963, DOI 10.1093/gerona/61.9.963
   von Känel R, 2014, J GERONTOL B-PSYCHOL, V69, P397, DOI 10.1093/geronb/gbt020
   von Känel R, 2006, J AM GERIATR SOC, V54, P431, DOI 10.1111/j.1532-5415.2005.00642.x
   von Känel R, 2020, J GERONTOL A-BIOL, V75, P2215, DOI 10.1093/gerona/glaa079
   Williamson GM, 2000, PL S SOC CL, P173
   Xu XY, 2020, J INT MED RES, V48, DOI 10.1177/0300060519845472
   Yudkin JS, 2000, ATHEROSCLEROSIS, V148, P209, DOI 10.1016/S0021-9150(99)00463-3
   Zhang B, 2018, IMMUNOL INVEST, V47, P689, DOI 10.1080/08820139.2018.1480034
   Zhou YQ, 2016, J NEUROINFLAMM, V13, DOI 10.1186/s12974-016-0607-6
NR 70
TC 1
Z9 1
U1 2
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD FEB-MAR
PY 2023
VL 85
IS 2
BP 175
EP 181
DI 10.1097/PSY.0000000000001158
PG 7
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 9K9QQ
UT WOS:000941194800008
PM 36516289
DA 2025-06-11
ER

PT J
AU Joung, KE
   Park, KH
   Zaichenko, L
   Sahin-Efe, A
   Thakkar, B
   Brinkoetter, M
   Usher, N
   Warner, D
   Davis, CR
   Crowell, JA
   Mantzoros, CS
AF Joung, Kyoung Eun
   Park, Kyung-Hee
   Zaichenko, Lesya
   Sahin-Efe, Ayse
   Thakkar, Bindiya
   Brinkoetter, Mary
   Usher, Nicole
   Warner, Dorothy
   Davis, Cynthia R.
   Crowell, Judith A.
   Mantzoros, Christos S.
TI Early Life Adversity Is Associated With Elevated Levels of Circulating
   Leptin, Irisin, and Decreased Levels of Adiponectin in Midlife Adults
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID STRESS; PLASMA; EXPRESSION; CHILDHOOD; EXERCISE; OBESITY; FNDC5; ABUSE;
   WOMEN; RISK
AB Context: Early-life adversity, defined as physical, emotional, or sexual abuse and neglect before 18 years of age, is associated with metabolic syndrome, obesity, and type 2 diabetes mellitus in adult life. However, the underlying mechanism is not fully understood, and whether adipomyokines are associated with early-life adversity independent of other factors such as body mass index, psychosocial risks, and health behaviors is not known.
   Objectives: The objective of the study was to evaluate the association between early-life adversity and circulating the levels of the adipomyokines such as leptin, adiponectin, and irisin and the inflammatory marker, C-reactive protein (CRP).
   Design/Subjects/Setting: This study was a cross-sectional study of 95 adults at a university-based research center. We collected venous blood from participants and analyzed serum for leptin, adiponectin, irisin, and CRP.
   Results: Circulating leptin, irisin, and CRP levels were significantly higher in the highest adversity tertile group compared with low and middle tertile groups (P < .001 for leptin, P = .01 for irisin, and P = .02 for CRP). Adiponectin levels were lower in the highest tertile group compared with the low and middle tertile groups (P = .03). After adjusting for demographic variables, physical activity, diet, current mental health, and body mass index, the associations between early-life adversity leptin, irisin, and did not change. However, adiponectin and CRP levels were no longer significantly related to early life adversity.
   Conclusion: Early-life adversity is directly associated with elevated circulating leptin and irisin, and indirectly associated with elevated CRP and decreased adiponectin. These findings suggest that these adipomyokines may play a role in the pathogenesis of metabolic abnormality in a population with significant early life adversity.
C1 [Joung, Kyoung Eun] Boston Childrens Hosp, Div Newborn Med, Boston, MA USA.
   [Joung, Kyoung Eun; Park, Kyung-Hee; Zaichenko, Lesya; Sahin-Efe, Ayse; Thakkar, Bindiya; Brinkoetter, Mary; Mantzoros, Christos S.] Beth Israel Deaconess Med Ctr, Div Endocrinol & Metab, Boston, MA 02215 USA.
   [Joung, Kyoung Eun; Mantzoros, Christos S.] Harvard Univ, Sch Med, Boston, MA 02215 USA.
   [Park, Kyung-Hee] Hallym Univ, Sacred Heart Hosp, Dept Family Med, Gyeonggi Do 431070, South Korea.
   [Zaichenko, Lesya; Sahin-Efe, Ayse; Thakkar, Bindiya; Brinkoetter, Mary; Mantzoros, Christos S.] Boston Vet Affairs Healthcare Syst, Div Endocrinol, Endocrinol Sect, Jamaica Plain, MA 02130 USA.
   [Sahin-Efe, Ayse; Thakkar, Bindiya; Mantzoros, Christos S.] Boston Univ, Sch Med, Boston Med Ctr, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA.
   [Usher, Nicole; Warner, Dorothy; Davis, Cynthia R.; Crowell, Judith A.] Judge Baker Childrens Ctr, Boston, MA 02120 USA.
   [Crowell, Judith A.] SUNY Stony Brook, Dept Psychiat & Behav Sci, Stony Brook, NY 11794 USA.
C3 Harvard University; Harvard University Medical Affiliates; Boston
   Children's Hospital; Harvard University; Harvard University Medical
   Affiliates; Beth Israel Deaconess Medical Center; Harvard University;
   Harvard Medical School; Hallym University; Boston University; Boston
   Medical Center; Harvard University; Harvard University Medical
   Affiliates; Judge Baker's Children's Center; State University of New
   York (SUNY) System; Stony Brook University
RP Mantzoros, CS (corresponding author), Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Endocrinol & Metab, FD 876,330 Brookline Ave, Boston, MA 02215 USA.
EM cmantzor@bidmc.harvard.edu
RI Park, Kyung/AAU-7867-2020; Mantzoros, Christos/Y-2902-2019
OI Joung, Kyoung Eun/0000-0002-5942-4241; Park, Kyung
   Hee/0000-0001-9806-0076; Zaichenko, Lesya/0000-0001-8489-3886
FU National Institute of Aging Grant [RO1-AG032030]; National Institute of
   Diabetes and Digestive and Kidney Diseases Grant [81913]; Harvard
   Clinical and Translational Science Center Grant from the National Center
   for Research Resources [UL1 RR025758]
FX This study was supported by the National Institute of Aging Grant
   RO1-AG032030 and National Institute of Diabetes and Digestive and Kidney
   Diseases Grant 81913. The project was also supported by Harvard Clinical
   and Translational Science Center Grant UL1 RR025758 from the National
   Center for Research Resources.
CR Ainsworth BE, 2011, MED SCI SPORT EXER, V43, P1575, DOI 10.1249/MSS.0b013e31821ece12
   Boström P, 2012, NATURE, V481, P463, DOI 10.1038/nature10777
   Boynton-Jarrett R, 2012, PEDIATRICS, V130, P245, DOI 10.1542/peds.2011-1554
   Carpenter LL, 2010, NEUROPSYCHOPHARMACOL, V35, P2617, DOI 10.1038/npp.2010.159
   DAVIS CR, 2013, METABOLISM, V63, P233
   Huh JY, 2012, METABOLISM, V61, P1725, DOI 10.1016/j.metabol.2012.09.002
   Johnson SB, 2013, PEDIATRICS, V131, P319, DOI 10.1542/peds.2012-0469
   Kertes DA, 2008, DEV PSYCHOPATHOL, V20, P473, DOI 10.1017/S0954579408000230
   Lecker SH, 2012, CIRC-HEART FAIL, V5, P812, DOI 10.1161/CIRCHEARTFAILURE.112.969543
   Mantzoros CS, 2011, AM J PHYSIOL-ENDOC M, V301, pE567, DOI 10.1152/ajpendo.00315.2011
   McCullough ML, 2002, AM J CLIN NUTR, V76, P1261, DOI 10.1093/ajcn/76.6.1261
   Park KH, 2013, J CLIN ENDOCR METAB, V98, P4899, DOI 10.1210/jc.2013-2373
   Rich-Edwards JW, 2010, AM J PREV MED, V39, P529, DOI 10.1016/j.amepre.2010.09.007
   Sanip Z, 2013, OBES RES CLIN PRACT, V7, pE315, DOI 10.1016/j.orcp.2012.05.002
   Shalev I, 2012, BIOESSAYS, V34, P943, DOI 10.1002/bies.201200084
   Slopen N, 2012, BRAIN BEHAV IMMUN, V26, P239, DOI 10.1016/j.bbi.2011.11.003
   Spranger J, 2003, LANCET, V361, P226, DOI 10.1016/S0140-6736(03)12255-6
   Szyf M, 2009, BBA-GEN SUBJECTS, V1790, P878, DOI 10.1016/j.bbagen.2009.01.009
   Yang WS, 2001, J CLIN ENDOCR METAB, V86, P3815, DOI 10.1210/jc.86.8.3815
   Zakrzewska KE, 1999, DIABETES, V48, P365, DOI 10.2337/diabetes.48.2.365
NR 20
TC 53
Z9 59
U1 0
U2 9
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JUN
PY 2014
VL 99
IS 6
BP E1055
EP E1060
DI 10.1210/jc.2013-3669
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AP8PI
UT WOS:000342340500017
PM 24650014
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Moran, LJ
   March, WA
   Whitrow, MJ
   Giles, LC
   Davies, MJ
   Moore, VM
AF Moran, L. J.
   March, W. A.
   Whitrow, M. J.
   Giles, L. C.
   Davies, M. J.
   Moore, V. M.
TI Sleep disturbances in a community-based sample of women with polycystic
   ovary syndrome
SO HUMAN REPRODUCTION
LA English
DT Article
DE polycystic ovary syndrome; sleep disturbances; depression; obesity
ID BODY-MASS INDEX; INSULIN-RESISTANCE; GLUCOSE-TOLERANCE;
   DIAGNOSTIC-CRITERIA; DAYTIME SLEEPINESS; METABOLIC SYNDROME;
   RISK-FACTOR; APNEA; METAANALYSIS; DEPRESSION
AB STUDY QUESTION: Is there an excess of sleep disturbances in women with polycystic ovary syndrome(PCOS) in a community-based sample?
   STUDY ANSWER: Sleep disturbances are almost twice as common in women with PCOS compared with women of similar age without PCOS, with the association slightly accounted for by body weight and, to a greater extent, by depressive symptoms.
   WHAT IS KNOWN ALREADY: There is an excess of sleep-disordered breathing in clinical samples of women with PCOS, after accounting for their profile of body weight. Poor sleep patterns increase insulin resistance and thus may exacerbate PCOS symptoms and longer-term risk of metabolic disease.
   STUDY DESIGN, SIZE, DURATION: Across-sectional study of 724 women, comprising 74% of a cohort study established retrospectively when women were around age 30 years.
   PARTICIPANTS/MATERIALS, SETTING, METHODS: Comparisons were made between 87 women with PCOS, diagnosed using the Rotterdam criteria, and 637 women without this diagnosis in Adelaide, South Australia. Differences in sleep disturbances, assessed using a modified version of the Jenkins questionnaire, were investigated using ordered logistic regression.
   MAIN RESULTS AND THE ROLE OF CHANCE: Sleep disturbances were twice as common in women with PCOS compared with those without. Specifically, PCOS was associated with increasing occurrence of difficulty falling asleep (odds ratio (OR) 1.94, 95% confidence interval (CI) 1.28-2.95); this association was attenuated but still statistically significant after accounting for BMI and depressive symptoms. Increasing occurrence of difficulty maintaining sleep (OR 1.92 95% CI 1.12-3.31) was mediated by obesity and depressive symptoms, together. Other factors did not change these findings.
   LIMITATIONS, REASONS FOR CAUTION: The cross-sectional nature of the study means that the direction of associations between PCOS and sleep disturbances is unclear, although bi-directionality for the mediators is likely based on data in the wider literature.
   WIDER IMPLICATIONS OF THE FINDINGS: Our results indicate that assessment and management of both sleep and mental health problems in women with PCOS should be undertaken. Longitudinal data would be valuable to see how poor sleep affects longer-term health profiles.
C1 [Moran, L. J.; March, W. A.; Whitrow, M. J.; Giles, L. C.; Davies, M. J.; Moore, V. M.] Univ Adelaide, Robinson Res Inst, Adelaide, SA, Australia.
   [Moran, L. J.; March, W. A.; Whitrow, M. J.; Davies, M. J.] Univ Adelaide, Sch Paediat & Reprod Hlth, Adelaide, SA, Australia.
   [Whitrow, M. J.; Giles, L. C.; Moore, V. M.] Univ Adelaide, Sch Populat Hlth, Adelaide, SA, Australia.
   [Moore, V. M.] Univ Adelaide, Fay Gale Ctr Res Gender, Adelaide, SA, Australia.
C3 Robinson Research Institute; University of Adelaide; University of
   Adelaide; University of Adelaide; University of Adelaide
RP Moran, LJ (corresponding author), Univ Adelaide, Robinson Res Inst, Adelaide, SA, Australia.
EM lisa.moran@adelaide.edu.au
RI Giles, Lynne/C-8789-2009; Whitrow, Melissa/J-4013-2012; Moran,
   Lisa/E-9850-2015; davies, michael/Y-3542-2018
OI Giles, Lynne/0000-0001-9054-9088; davies, michael/0000-0003-1526-0801;
   Moran, Lisa/0000-0001-5772-6484; Whitrow, Melissa/0009-0006-0069-0031
FU Australian National Health and Medical Research Council [465455, 627033,
   349548]; Australian Research Council [FT100101018]; South Australian
   Cardiovascular Research Development Program (SACVRDP) Fellowship
   [ACI1S374]; National Heart Foundation of Australia; South Australian
   Department of Health; South Australian Health and Medical Research
   Institute; Australian Research Council [FT100101018] Funding Source:
   Australian Research Council
FX This study was supported by Australian National Health and Medical
   Research Council (Strategic Award 465455, Public Health Training
   Fellowship 627033 to L.C.G., Career Development Award in Population
   Health 349548 to M.J.D.) and the Australian Research Council (Future
   Fellowship FT100101018 to M.J.D.). L.J.M. was supported by a South
   Australian Cardiovascular Research Development Program (SACVRDP)
   Fellowship (ACI1S374); a program collaboratively funded by the National
   Heart Foundation of Australia, the South Australian Department of Health
   and the South Australian Health and Medical Research Institute.
CR Alvaro PK, 2013, SLEEP, V36, P1059, DOI 10.5665/sleep.2810
   Asghari A, 2012, EUR ARCH OTO-RHINO-L, V269, P2549, DOI 10.1007/s00405-012-1942-6
   Barry JA, 2011, HUM REPROD, V26, P2442, DOI 10.1093/humrep/der197
   BENNETT SA, 1994, MED J AUSTRALIA, V161, P519, DOI 10.5694/j.1326-5377.1994.tb127594.x
   Benson S, 2009, PSYCHONEUROENDOCRINO, V34, P727, DOI 10.1016/j.psyneuen.2008.12.001
   Bixler EO, 2005, J CLIN ENDOCR METAB, V90, P4510, DOI 10.1210/jc.2005-0035
   Cappuccio FP, 2010, DIABETES CARE, V33, P414, DOI 10.2337/dc09-1124
   Chang J, 2004, FERTIL STERIL, V81, P19, DOI 10.1016/j.fertnstert.2003.10.004
   Choi NG, 2011, AGING MENT HEALTH, V15, P720, DOI 10.1080/13607863.2010.551343
   Dezee KJ, 2006, SLEEP MED, V7, P327, DOI 10.1016/j.sleep.2005.11.001
   Dunaif A, 1996, J CLIN ENDOCR METAB, V81, P942, DOI 10.1210/jc.81.3.942
   Ezeh U, 2013, J CLIN ENDOCR METAB, V98, pE1088, DOI 10.1210/jc.2013-1295
   Ford ES, 2014, OBESITY, V22, P598, DOI 10.1002/oby.20558
   Jedel E, 2010, HUM REPROD, V25, P450, DOI 10.1093/humrep/dep384
   JENKINS CD, 1988, J CLIN EPIDEMIOL, V41, P313, DOI 10.1016/0895-4356(88)90138-2
   Lai YJ, 2013, SLEEP MED, V14, P913, DOI 10.1016/j.sleep.2013.03.024
   Lawrence D, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-285
   Liang WB, 2011, BRIT J PSYCHIAT, V199, P219, DOI 10.1192/bjp.bp.110.086116
   Lim SS, 2012, HUM REPROD UPDATE, V18, P618, DOI 10.1093/humupd/dms030
   Luboshitzky R, 2001, FERTIL STERIL, V76, P506, DOI 10.1016/S0015-0282(01)01930-6
   March WA, 2010, HUM REPROD, V25, P544, DOI 10.1093/humrep/dep399
   Moran LJ, 2010, HUM REPROD UPDATE, V16, P347, DOI 10.1093/humupd/dmq001
   Naismith S, 2004, J CLIN EXP NEUROPSYC, V26, P43, DOI 10.1076/jcen.26.1.43.23929
   Nedeltcheva AV, 2009, J CLIN ENDOCR METAB, V94, P3242, DOI 10.1210/jc.2009-0483
   Owens JF, 1998, MATURITAS, V30, P41, DOI 10.1016/S0378-5122(98)00039-5
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Peppard PE, 2006, ARCH INTERN MED, V166, P1709, DOI 10.1001/archinte.166.16.1709
   Pillar G, 1998, CHEST, V114, P697, DOI 10.1378/chest.114.3.697
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   REDLINE S, 1994, AM J RESP CRIT CARE, V149, P722, DOI 10.1164/ajrccm.149.3.8118642
   Shreeve N, 2013, HUM REPROD, V28, P1348, DOI 10.1093/humrep/det013
   Spiegel K, 2005, J APPL PHYSIOL, V99, P2008, DOI 10.1152/japplphysiol.00660.2005
   Tasali E, 2008, J CLIN ENDOCR METAB, V93, P3878, DOI 10.1210/jc.2008-0925
   Van Cauter E, 2011, DIABETIC MED, V28, P1455, DOI 10.1111/j.1464-5491.2011.03459.x
   Vgontzas Alexandros N., 2008, Archives of Physiology and Biochemistry, V114, P211, DOI [10.1080/13813450802364627, 10.1080/13813450802364627 ]
   Vgontzas AN, 2001, J CLIN ENDOCR METAB, V86, P517, DOI 10.1210/jc.86.2.517
   WEISSMAN MM, 1977, AM J EPIDEMIOL, V106, P203, DOI 10.1093/oxfordjournals.aje.a112455
   World Health Organization Health-Wealth Connection Collaborative, 1995, PHYS STAT US INT ANT
   Xiong YL, 2011, EUR J OBSTET GYN R B, V159, P148, DOI 10.1016/j.ejogrb.2011.07.012
NR 39
TC 70
Z9 72
U1 1
U2 10
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0268-1161
EI 1460-2350
J9 HUM REPROD
JI Hum. Reprod.
PD FEB
PY 2015
VL 30
IS 2
BP 466
EP 472
DI 10.1093/humrep/deu318
PG 7
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA CC2AK
UT WOS:000350146600024
PM 25432918
OA Bronze
DA 2025-06-11
ER

PT J
AU Stuebe, A
AF Stuebe, Alison
TI Associations Among Lactation, Maternal Carbohydrate Metabolism, and
   Cardiovascular Health
SO CLINICAL OBSTETRICS AND GYNECOLOGY
LA English
DT Article
DE lactation; hypertension; diabetes; metabolic syndrome; myocardial
   infarction
ID BODY-MASS INDEX; FEEDING INTERVENTION TRIAL; LONG-TERM DECREASE;
   BLOOD-PRESSURE; PSYCHOSOCIAL STRESS; DIABETES-MELLITUS;
   LIPID-METABOLISM; RISK-FACTORS; OBESE WOMEN; WEIGHT-LOSS
AB In mammalian reproductive physiology, lactation follows pregnancy; growing evidence suggests that disruption of this physiology affects a woman's lifetime risk of metabolic disease. These differences may reflect lactation-induced mobilization of fat stores and modulation of maternal stress reactivity. In addition, confounders may play a role: women who breastfeed for long durations are more likely to engage in other healthy behaviors, and obesity and insulin resistance may interfere with breastfeeding physiology. These findings underscore the importance of evidenced-based care to enable women to achieve their infant feeding goals.
C1 [Stuebe, Alison] Univ N Carolina, Sch Med, Maternal Fetal Med, Chapel Hill, NC 27599 USA.
   [Stuebe, Alison] Gillings Sch Global Publ Hlth, Carolina Global Breastfeeding Inst, Maternal & Child Hlth, Chapel Hill, NC USA.
C3 University of North Carolina School of Medicine; University of North
   Carolina; University of North Carolina Chapel Hill
RP Stuebe, A (corresponding author), Univ N Carolina, Sch Med, Maternal Fetal Med, 3010 Old Clin Bldg,CB 7516, Chapel Hill, NC 27599 USA.
EM astuebe@med.unc.edu
FU Lactation Effects on Postnatal Endothelial Function and Vascular
   Inflammation [R01HL109216-01A1]
FX Supported in part by R01HL109216-01A1, Lactation Effects on Postnatal
   Endothelial Function and Vascular Inflammation. The content is solely
   the responsibility of the author and does not necessarily represent the
   official views of the National Institutes of Health.
CR Academy of Breastfeeding Medicine Protocol Committee, 2009, Breastfeed Med, V4, P43
   Altemus M, 2001, PSYCHOSOM MED, V63, P814, DOI 10.1097/00006842-200109000-00015
   Amir Lisa H, 2007, BMC Pregnancy Childbirth, V7, P9, DOI 10.1186/1471-2393-7-9
   [Anonymous], 2016, COCHRANE DB SYST REV
   Aune D, 2014, NUTR METAB CARDIOVAS, V24, P107, DOI 10.1016/j.numecd.2013.10.028
   Baker JL, 2007, AM J CLIN NUTR, V86, P404, DOI 10.1093/ajcn/86.2.404
   Baker JL, 2008, AM J CLIN NUTR, V88, P1543, DOI 10.3945/ajcn.2008.26379
   Beck Laurie F, 2002, MMWR Surveill Summ, V51, P1
   Bobrow KL, 2013, INT J OBESITY, V37, P712, DOI 10.1038/ijo.2012.76
   Bunik M, 2010, BREASTFEED MED, V5, P87, DOI 10.1089/bfm.2010.9994
   Butte NF, 2001, J NUTR, V131, P53, DOI 10.1093/jn/131.1.53
   Carlsen EM, 2013, AM J CLIN NUTR, V98, P1226, DOI 10.3945/ajcn.113.059600
   Chapman DJ, 2013, PEDIATRICS, V131, pE162, DOI 10.1542/peds.2012-0688
   Chouinard-Castonguay S, 2013, EUR J ENDOCRINOL, V168, P515, DOI 10.1530/EJE-12-0939
   Dall SRX, 2004, P ROY SOC B-BIOL SCI, V271, P2049, DOI 10.1098/rspb.2004.2830
   DARMADY JM, 1982, BRIT J OBSTET GYNAEC, V89, P211, DOI 10.1111/j.1471-0528.1982.tb03616.x
   DEWEY KG, 1993, AM J CLIN NUTR, V58, P162, DOI 10.1093/ajcn/58.2.162
   Dewey KG, 2001, J NUTR, V131, P262, DOI 10.1093/jn/131.2.262
   DiGirolamo AM, 2008, PEDIATRICS, V122, pS43, DOI 10.1542/peds.2008-1315e
   Donath S M, 2000, Breastfeed Rev, V8, P29
   ERKKOLA R, 1986, BIOL RES PREG PERIN, V7, P47
   Finkelstein SA, 2013, DIABETIC MED, V30, P1094, DOI 10.1111/dme.12238
   Grewen KM, 2011, BIOL PSYCHOL, V87, P340, DOI 10.1016/j.biopsycho.2011.04.003
   Gunderson EP, 2014, METABOLISM, V63, P941, DOI 10.1016/j.metabol.2014.04.006
   Gunderson EP, 2012, OBSTET GYNECOL, V120, P136, DOI 10.1097/AOG.0b013e31825b993d
   Hahn-Holbrook J, 2011, PSYCHOL SCI, V22, P1288, DOI 10.1177/0956797611420729
   Hauff LE, 2014, AM J CLIN NUTR, V99, P524, DOI 10.3945/ajcn.113.071191
   Heinrichs M, 2001, J CLIN ENDOCR METAB, V86, P4798, DOI 10.1210/jc.86.10.4798
   Hilson JA, 1997, AM J CLIN NUTR, V66, P1371, DOI 10.1093/ajcn/66.6.1371
   Hilson JA, 2004, J HUM LACT, V20, P18, DOI 10.1177/0890334403261345
   Howard C, 2000, OBSTET GYNECOL, V95, P296, DOI 10.1016/S0029-7844(99)00555-4
   Hung KJ, 2011, MCN-AM J MATERN-CHIL, V36, P318, DOI 10.1097/NMC.0b013e3182266314
   Jäger S, 2014, DIABETOLOGIA, V57, P1355, DOI 10.1007/s00125-014-3247-3
   Japundzic-Zigon N, 2013, CURR NEUROPHARMACOL, V11, P218, DOI 10.2174/1570159X11311020008
   Jones JR, 2011, PEDIATRICS, V128, P1117, DOI 10.1542/peds.2011-0841
   KALLIO MJT, 1992, METABOLISM, V41, P1327, DOI 10.1016/0026-0495(92)90103-H
   Karnik SK, 2007, SCIENCE, V318, P806, DOI 10.1126/science.1146812
   KJOS SL, 1993, OBSTET GYNECOL, V82, P451
   KNOPP RH, 1985, J CLIN ENDOCR METAB, V60, P542, DOI 10.1210/jcem-60-3-542
   Kramer MS, 2001, JAMA-J AM MED ASSOC, V285, P413, DOI 10.1001/jama.285.4.413
   Lankarani-Fard A, 2001, J WOMEN HEALTH GEN-B, V10, P681, DOI 10.1089/15246090152563560
   Lee SY, 2005, PREV MED, V41, P433, DOI 10.1016/j.ypmed.2004.11.025
   Lemay DG, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0067531
   Lind JN, 2014, MMWR-MORBID MORTAL W, V63
   Liu B, 2010, DIABETES CARE, V33, P1239, DOI 10.2337/dc10-0347
   Lovelady CA, 2000, NEW ENGL J MED, V342, P449, DOI 10.1056/NEJM200002173420701
   Matias SL, 2014, AM J CLIN NUTR, V99, P115, DOI 10.3945/ajcn.113.073049
   McManus RM, 2001, METABOLISM, V50, P715, DOI 10.1053/meta.2001.23304
   Mezzacappa ES, 2005, J PSYCHOSOM RES, V58, P351, DOI 10.1016/j.jpsychores.2004.11.004
   Much D, 2014, MOL METAB, V3, P284, DOI 10.1016/j.molmet.2014.01.002
   Natland ST, 2012, INT BREASTFEED J, V7, DOI 10.1186/1746-4358-7-8
   Nommsen-Rivers LA, 2012, BREASTFEED MED, V7, P43, DOI 10.1089/bfm.2011.0007
   Nommsen-Rivers LA, 2010, AM J CLIN NUTR, V92, P574, DOI 10.3945/ajcn.2010.29192
   O'Reilly MW, 2011, EUR J ENDOCRINOL, V165, P953, DOI 10.1530/EJE-11-0663
   Oddy WH, 2006, J PEDIATR-US, V149, P185, DOI 10.1016/j.jpeds.2006.04.005
   Ohlin A, 1996, OBES RES, V4, P271
   Oken E, 2013, AM J CLIN NUTR, V98, P1048, DOI 10.3945/ajcn.113.065300
   Oza-Frank R, 2015, PUBLIC HEALTH NUTR, V18, P727, DOI 10.1017/S1368980014000792
   Pang WW, 2007, J MAMMARY GLAND BIOL, V12, P211, DOI 10.1007/s10911-007-9054-4
   Pesa JA, 1999, PUBLIC HEALTH NURS, V16, P120, DOI 10.1046/j.1525-1446.1999.00120.x
   Petersson M, 1999, J CARDIOVASC PHARM, V33, P102, DOI 10.1097/00005344-199901000-00015
   Petersson M, 1996, PHYSIOL BEHAV, V60, P1311, DOI 10.1016/S0031-9384(96)00261-2
   Poole AT, 2014, AM J OBSTET GYNECOL, V211, DOI 10.1016/j.ajog.2014.06.004
   Ram KT, 2008, AM J OBSTET GYNECOL, V198, DOI 10.1016/j.ajog.2007.11.044
   Rasmussen KM, 2011, BREASTFEED MED, V6, P69, DOI 10.1089/bfm.2010.0014
   Rasmussen KM, 2001, J NUTR, V131, p3009S, DOI 10.1093/jn/131.11.3009S
   Rasmussen KM, 2004, PEDIATRICS, V113, pE465, DOI 10.1542/peds.113.5.e465
   Rooney BL, 2002, OBSTET GYNECOL, V100, P245, DOI 10.1016/S0029-7844(02)02125-7
   Schwarz EB, 2010, AM J MED, V123, DOI 10.1016/j.amjmed.2010.03.016
   Schwarz EB, 2009, OBSTET GYNECOL, V113, P974, DOI 10.1097/01.AOG.0000346884.67796.ca
   Sparks PJ, 2011, WOMEN HEALTH ISS, V21, P374, DOI 10.1016/j.whi.2011.03.002
   Stuebe AM, 2014, OBSTET GYNECOL, V123, P643, DOI 10.1097/AOG.0000000000000142
   Stuebe AM, 2011, AM J EPIDEMIOL, V174, P1147, DOI 10.1093/aje/kwr227
   Stuebe AM, 2009, AM J PERINAT, V26, P81, DOI 10.1055/s-0028-1103034
   Stuebe AM, 2005, JAMA-J AM MED ASSOC, V294, P2601, DOI 10.1001/jama.294.20.2601
   Szucs KA, 2013, PEDIATRICS, V131, pE1982, DOI 10.1542/peds.2012-3479
   Tu MT, 2006, J NEUROENDOCRINOL, V18, P494, DOI 10.1111/j.1365-2826.2006.01441.x
   Valeggia C, 2009, AM J HUM BIOL, V21, P559, DOI 10.1002/ajhb.20907
   Villegas R, 2008, DIABETOLOGIA, V51, P258, DOI 10.1007/s00125-007-0885-8
   Wight N, 2014, BREASTFEED MED, V9, P173, DOI 10.1089/bfm.2014.9986
   Wojcicki JM, 2011, J WOMENS HEALTH, V20, P341, DOI 10.1089/jwh.2010.2248
   ZHONG SB, 1990, METABOLISM, V39, P1127, DOI 10.1016/0026-0495(90)90083-O
   Ziegler AG, 2012, DIABETES, V61, P3167, DOI 10.2337/db12-0393
NR 83
TC 33
Z9 36
U1 0
U2 28
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-9201
EI 1532-5520
J9 CLIN OBSTET GYNECOL
JI Clin. Obstet. Gynecol.
PD DEC
PY 2015
VL 58
IS 4
BP 827
EP 839
DI 10.1097/GRF.0000000000000155
PG 13
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA CV3KO
UT WOS:000364158300012
PM 26457850
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Lindley, KJ
   Barker, C
   Mahmoud, Z
   Raghuraman, N
   Lenzen, P
   Meyers, R
   Osmundson, S
   Huang, S
   Shah, RV
   Davila-Roman, VG
AF Lindley, Kathryn J.
   Barker, Claire
   Mahmoud, Zainab
   Raghuraman, Nandini
   Lenzen, Patricia
   Meyers, Rachel
   Osmundson, Sarah
   Huang, Shi
   Shah, Ravi V.
   Davila-Roman, Victor G.
TI Decreased postpartum exercise capacity after a diagnosis of
   pre-eclampsia: Implications for CVD risk prediction
SO AMERICAN HEART JOURNAL
LA English
DT Article
ID VENTRICULAR DIASTOLIC FUNCTION; RECOMMENDATIONS; PREGNANCY; DISEASE
AB Background Hypertensive disorders of pregnancy (HDP) are associated with increased long-term risk for cardiometabolic risk factors (chronic hypertension [HTN], obesity, diabetes) and heart failure. Exercise capacity is a known predictor of heart failure in patients with normal resting cardiac filling pressures. In this prospective observational cohort study, we sought to identify predictors of reduced postpartum exercise capacity in participants with normotensive vs preeclamptic pregnancies. Methods Preeclampsia (PreE) and normotensive subjects were enrolled to undergo bedside echocardiography within 48 hours of delivery, and rest/exercise echocardiography 12 weeks postpartum. Results Recruited subjects (n = 68) were grouped according to their blood pressure as: a) normotensive pregnancy n = 15; b) PreE with normotensive postpartum (PreE-Resolved, n = 36); c) PreE with persistent postpartum HTN (PreE-HTN, n = 17). At enrollment, a significantly higher percentage of subjects in the PreE-HTN group were Black. Compared to normotensive and PreE-Resolved subjects, those with PreE-HTN demonstrated higher resting systolic blood pressure (SBP, 112 [normotensive] vs 112 [PreE-Resolved] vs 134 [PreE-HTN], P < .001) and diastolic blood pressure (DBP, 70.0 vs 72.5 vs 85.0, P < .001), and significantly less postpartum weight loss (9.6% vs 13.6% vs 3.8%, P < .001). Following Bruce protocol stress testing, PreE-HTN subjects demonstrated achieved significantly lower exercise duration (10.4 vs 10.2 vs 7.9 minutes, P = .001). Subjects with PreE-HTN also demonstrated evidence of exercise-induced diastolic dysfunction as assessed by peak exercise lateral e' (18.0 vs 18.0 vs 13.5, P = .045) and peak exercise tricuspid regurgitation velocity (TR Vm, 2.4 vs 3.0 vs 3.1, P = 0.045). Exercise duration was negatively associated with gravidity (R = -0.27, P = .029) and postpartum LV mass index (R = -0.45, P < .001), resting average E/e' (R = -0.51, P < .001), BMI (R = -0.6, P < .001) and resting SBP (R = -0.51, P < .001). Conclusions Postpartum exercise stress testing capacity is related to readily available clinical markers including pregnancy factors, echocardiographic parameters and unresolved cardiometabolic risk factors.
C1 [Lindley, Kathryn J.; Huang, Shi; Shah, Ravi V.] Vanderbilt Univ, Med Ctr, Dept Med, Cardiovasc Div, Nashville, TN 37232 USA.
   [Lindley, Kathryn J.; Osmundson, Sarah] Vanderbilt Univ, Med Ctr, Dept Obstet & Gynecol, Nashville, TN 37232 USA.
   [Barker, Claire] Univ Toledo, Coll Med & Life Sci, Toledo, OH USA.
   [Mahmoud, Zainab; Lenzen, Patricia; Meyers, Rachel; Davila-Roman, Victor G.] Washington Univ, Dept Med, Cardiovasc Div, St Louis, MO USA.
   [Raghuraman, Nandini] Washington Univ, Dept Obstet & Gynecol, St Louis, MO USA.
C3 Vanderbilt University; Vanderbilt University; University System of Ohio;
   University of Toledo; Washington University (WUSTL); Washington
   University (WUSTL)
RP Lindley, KJ (corresponding author), Vanderbilt Univ, Sch Med, Cardiovasc Div, 1215 21st Ave South,Suite 5209, Nashville, TN 37232 USA.
EM Kathryn.lindley@vumc.org
RI Osmundson, Sarah/AGX-8036-2022; Lindley, Kathryn/MFH-6654-2025; Shah,
   Ravi/KLD-0068-2024
OI Lindley, Kathryn/0000-0002-8504-0006
CR Addicott K, 2024, AM J PERINAT, V41, P1275, DOI 10.1055/a-2107-1585
   Ananth CV, 2021, HYPERTENSION, V78, P1414, DOI 10.1161/HYPERTENSIONAHA.121.17661
   Benjamin, 2018, CIRCULATION, V137, pE493, DOI 10.1161/CIR.0000000000000573
   Benschop L, 2019, HEART, V105, P1273, DOI 10.1136/heartjnl-2018-313453
   Eisman AS, 2018, CIRC-HEART FAIL, V11, DOI 10.1161/CIRCHEARTFAILURE.117.004750
   Espinoza J, 2020, OBSTET GYNECOL, V135, pE237, DOI 10.1097/AOG.0000000000003891
   Honigberg MC, 2019, J AM COLL CARDIOL, V74, P2743, DOI 10.1016/j.jacc.2019.09.052
   Hoyert D, 2024, Mortality Rates in the United States, 2022
   Johnson D, 2023, MIL MED, V188, pE1076, DOI 10.1093/milmed/usab429
   Khan SS, 2023, CIRC RES, V132, P1584, DOI 10.1161/CIRCRESAHA.123.322001
   KRUMHOLZ HM, 1995, J AM COLL CARDIOL, V25, P879, DOI 10.1016/0735-1097(94)00473-4
   Lindley KJ, 2020, INT J CARDIOVAS IMAG, V36, P1637, DOI 10.1007/s10554-020-01866-w
   Maynard SE, 2005, PEDIATR RES, V57, p1R, DOI 10.1203/01.PDR.0000159567.85157.B7
   Melchiorre K, 2011, HYPERTENSION, V58, P709, DOI 10.1161/HYPERTENSIONAHA.111.176537
   Mostello D, 2010, OBSTET GYNECOL, V116, P667, DOI 10.1097/AOG.0b013e3181ed74ea
   Nagueh SF, 2016, J AM SOC ECHOCARDIOG, V29, P277, DOI 10.1016/j.echo.2016.01.011
   Nagueh SF, 2009, EUR J ECHOCARDIOGR, V10, P165, DOI [10.1093/ejechocard/jep007, 10.1016/j.echo.2008.11.023]
   Pepine CJ, 2020, INT J CARDIOL, V304, P101, DOI 10.1016/j.ijcard.2020.01.003
   Pieske B, 2019, EUR HEART J, V40, P3297, DOI 10.1093/eurheartj/ehz641
   Powe CE, 2011, CIRCULATION, V123, P2856, DOI 10.1161/CIRCULATIONAHA.109.853127
   Rosenbloom JI, 2020, OBSTET GYNECOL, V135, P27, DOI 10.1097/AOG.0000000000003567
   Shirasuna K, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00080
   Theilen LH, 2016, OBSTET GYNECOL, V128, P238, DOI 10.1097/AOG.0000000000001534
   Whelton Paul K, 2018, J Am Coll Cardiol, V71, pe127, DOI 10.1016/j.jacc.2017.11.006
   Williams D, 2021, J AM COLL CARDIOL, V78, P2281, DOI 10.1016/j.jacc.2021.09.1360
   Yokoyama T, 1997, CIRCULATION, V95, P1247
NR 26
TC 0
Z9 0
U1 2
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-8703
EI 1097-6744
J9 AM HEART J
JI Am. Heart J.
PD SEP
PY 2024
VL 275
BP 192
EP 199
DI 10.1016/j.ahj.2024.06.002
EA AUG 2024
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA C3R1Z
UT WOS:001288553000001
PM 38944263
OA hybrid
DA 2025-06-11
ER

PT J
AU Babic, D
   Martinac, M
   Bjelanovic, V
   Babic, R
   Sutovic, A
   Sinanovic, O
AF Babic, Dragan
   Martinac, Marko
   Bjelanovic, Vedran
   Babic, Romana
   Sutovic, Alija
   Sinanovic, Osman
TI Aggression in War Veterans Suffering from Posttraumatic Stress Disorder
   with Co-morbid Alcoholism
SO COLLEGIUM ANTROPOLOGICUM
LA English
DT Article
DE aggression; posttraumatic stress disorder; alcoholism
ID COMBAT VETERANS; METABOLIC SYNDROME; DEPENDENCE; SYMPTOMS; BEHAVIOR;
   VIOLENCE; VIETNAM; PTSD; ASSOCIATION; DEPRESSION
AB For thousands of years it has been known that aggression as a symptom appears in numerous psychiatric disorders and diseases. During the last decade the appearance of the aggressive behavior related to the posttraumatic stress disorder (PTSD) has been frequently investigated, often associated with war trauma. The goal of this study is to analyze the impact of alcoholism on a way war veterans suffering from chronic PTSD express and control aggression. The sample included 240 war veterans with chronic PTSD. The subjects were divided in two groups. PTSD group (n=147) and controlled group composed of those suffering from alcoholism in addition to PTSD (n=93). In this study, the following psychological instruments were used: The Harvard trauma questionnaire for PTSD diagnosis (HTQ); the questionnaire for self-evaluation of aggression (S TAXI); The Profile Index Emotion (PIE); questionnaire for auto-diagnosis of alcoholism (CAGE). The obtained results indicate that subjects who have PTSD with co-morbid alcoholism are more deprived, aggressive (p<0.001) and oppositional (p<0.05) in comparison to subjects whose PTSD is not combined with alcoholism (PIE). The aggression is statistically more expressed in subjects with PTSD who have also been diagnosed with alcoholism on all subscales in comparison to subjects with PTDS who have not been diagnosed with alcoholism: the current state of aggression, the general state of aggression, aggression towards an unfair treatment, aggression directed inwards and outwards (p<0.001); aggression towards nonspecific provocation and a general way of expressing aggression (p<0.05) (STAXI). Subjects that had PTSD combined with alcoholism show a higher degree of aggression in comparison to subjects with PTDS who are not diagnosed with alcoholism.
C1 [Babic, Dragan] Univ Hosp Mostar, Dept Psychiat, Mostar 88000, Bosnia & Herceg.
   [Martinac, Marko] Univ Mostar, Fac Med, Ctr Prevent & Outpatient Treatment Addict Mostar, Mostar, Bosnia & Herceg.
   [Bjelanovic, Vedran] Univ Hosp Mostar, Dept Gynecol, Mostar 88000, Bosnia & Herceg.
   [Babic, Romana] Univ Mostar, Fac Med, Mostar, Bosnia & Herceg.
   [Sutovic, Alija] Univ Tuzla, Fac Med, Inst Publ Hlth, Dept Psychiat, Tuzla, Bosnia & Herceg.
   [Sinanovic, Osman] Univ Tuzla, Fac Med, Publ Hlth Inst Tuzla, Dept Neurol, Tuzla, Bosnia & Herceg.
C3 University of Mostar; University of Mostar; University of Mostar;
   University of Mostar; University of Tuzla; University of Tuzla
RP Babic, D (corresponding author), Univ Hosp Mostar, Dept Psychiat, Mostar 88000, Bosnia & Herceg.
EM dragan.babic@tel.net.ba
CR BABIC D, 2004, NEUROL CROATICA, V53, P159
   Babic D, 2007, PSYCHIAT DANUB, V19, P68
   Babic Dragan, 2003, Psychiatr Danub, V15, P195
   Baskovec-Milinkovic A., 1979, PRIRUCNIK UPOTREBU P
   Begic D, 2001, MIL MED, V166, P671, DOI 10.1093/milmed/166.8.671
   Begic D, 2002, CURR OPIN PSYCHIATR, V15, P623, DOI 10.1097/00001504-200211000-00011
   BEGIC D, 2000, SOC PSIHIJAT, V28, P105
   Brewin CR, 2000, J CONSULT CLIN PSYCH, V68, P748, DOI 10.1037/0022-006X.68.5.748
   Buljan Danijel, 2002, Alcoholism (Zagreb), V38, P35
   David D, 2004, PSYCHIAT SERV, V55, P82, DOI 10.1176/appi.ps.55.1.82
   Freeman TW, 2001, J NERV MENT DIS, V189, P317, DOI 10.1097/00005053-200105000-00008
   HILEYYOUNG B, 1995, J TRAUMA STRESS, V8, P125, DOI 10.1007/BF02105411
   Jakovljevic M, 2008, PSYCHIAT DANUB, V20, P406
   Kaplan H., 1998, PRIRUCNIK KLIN PSIHI
   Kozaric-Kovacic D, 2000, CROAT MED J, V41, P173
   LAMOVEC T, 1990, UPITNIK ZIVOTNOG STI
   LANG B, 1992, RATNA PSIHOLOGIJA PS
   MCNALLY RJ, 1995, AM J PSYCHIAT, V152, P936
   MOLICA RF, 1992, HARVARD TRAUMA MANUA
   Najavits LM, 2004, ADDICT BEHAV, V29, P707, DOI 10.1016/j.addbeh.2004.01.003
   Oquendo MA, 2003, AM J PSYCHIAT, V160, P580, DOI 10.1176/appi.ajp.160.3.580
   Pavic L, 2003, EUR ARCH PSY CLIN N, V253, P80, DOI 10.1007/s00406-003-0411-z
   PLUTCHICK RI, 1970, PROFIL INDEKS EMOCIJ
   POROT A, 1990, ENCIKLOPEDIJA PSIHIJ
   Spielberger C.D., 1986, The Anger Expression (AX) Scale
   Steindl SR, 2003, J TRAUMA STRESS, V16, P27, DOI 10.1023/A:1022055110238
   Taft CT, 2007, J ABNORM PSYCHOL, V116, P498, DOI 10.1037/0021-843X.116.3.498
   Trief PM, 2006, J BEHAV MED, V29, P411, DOI 10.1007/s10865-006-9067-2
   Wilson J.P., 2004, ASSESSING PSYCHOL TR, V2nd
   Zatzick DF, 1997, AM J PSYCHIAT, V154, P1690, DOI 10.1176/ajp.154.12.1690
   Zoricic Z, 2003, EUR J PSYCHIAT, V17, P243
   Zoricic Z, 2003, NORD J PSYCHIAT, V57, P199, DOI 10.1080/08039480310001337
   Zoricic Zoran, 2002, Alcoholism (Zagreb), V38, P3
   Zorieia Z., 2002, Acta clin Croat, V41, P319
NR 34
TC 7
Z9 7
U1 0
U2 5
PU COLLEGIUM ANTROPOLOGICUM
PI ZAGREB
PA INST ANTHROPOLOGICAL RES, P O BOX 290, ULICA GRADA VUKOVARA 72/IV, 10000
   ZAGREB, CROATIA
SN 0350-6134
J9 COLLEGIUM ANTROPOL
JI Coll. Anthropol.
PD MAR
PY 2010
VL 34
SU 1
BP 23
EP 28
PG 6
WC Anthropology
WE Social Science Citation Index (SSCI)
SC Anthropology
GA 577OB
UT WOS:000276232100005
PM 20402291
DA 2025-06-11
ER

PT J
AU Uchio, R
   Muroyama, K
   Okuda-Hanafusa, C
   Kawasaki, K
   Yamamoto, Y
   Murosaki, S
AF Uchio, Ryusei
   Muroyama, Koutarou
   Okuda-Hanafusa, Chinatsu
   Kawasaki, Kengo
   Yamamoto, Yoshihiro
   Murosaki, Shinji
TI Hot Water Extract of Curcuma longa L. Improves Serum Inflammatory
   Markers and General Health in Subjects with Overweight or
   Prehypertension/Mild Hypertension: A Randomized, Double-Blind,
   Placebo-Controlled Trial
SO NUTRIENTS
LA English
DT Article
DE turmeric (Curcuma longa L.); bisacurone; turmeronol; chronic
   inflammation; C-reactive protein; glucose; hemoglobin A1c; high-density
   cholesterol; short-form 36-item health survey; profile of mood states
ID C-REACTIVE PROTEIN; LOW-GRADE INFLAMMATION; QUALITY-OF-LIFE; METABOLIC
   SYNDROME; INHIBITS ADHESION; ENDOTHELIAL-CELLS; OXIDATIVE STRESS;
   HEART-DISEASE; JAPANESE; RISK
AB To investigate the effect of a hot water extract of C. longa L. (WEC) containing anti-inflammatory agents, bisacurone, and turmeronol on chronic inflammation, a randomized double-blind placebo-controlled study was conducted in middle-aged and elderly subjects aged 50-69 years with overweight or prehypertension/mild hypertension. The subjects consumed 900 mg WEC tablets, containing 400 mu g bisacurone, 80 mu g turmeronol A and 20 mu g turmeronol B (WEC group: n = 45), or placebo tablets without WEC (placebo group: n = 45) daily for 12 weeks. Serum inflammatory and metabolic markers were measured. The subjects also completed the MOS 36-item short-form health survey (SF-36) and the Profile of Mood States scale (POMS). In the WEC group, the serum levels of C-reactive protein, tumor necrosis factor-alpha, interleukin-6, and soluble vascular cell adhesion molecule-1 decreased significantly. Compared with the placebo group, the WEC group had significantly lower serum levels of glucose, hemoglobin A1c, and triglycerides, as well as higher serum levels of high-density lipoprotein cholesterol. The WEC group also showed significant improvement of SF-36 scores (for general health, vitality, mental health, and mental summary component) and POMS scores for positive mood states (vigor-activity and friendliness). In conclusion, WEC may ameliorate chronic low-grade inflammation, thus contributing to the improvement of associated metabolic disorders and general health.
C1 [Uchio, Ryusei; Muroyama, Koutarou; Okuda-Hanafusa, Chinatsu; Kawasaki, Kengo; Yamamoto, Yoshihiro; Murosaki, Shinji] House Wellness Foods Corp, Res & Dev Inst, 3-20 Imoji, Itami, Hyogo 6640011, Japan.
RP Uchio, R (corresponding author), House Wellness Foods Corp, Res & Dev Inst, 3-20 Imoji, Itami, Hyogo 6640011, Japan.
EM uchio_ryusei@house-wf.co.jp
RI Uchio, Ryusei/X-2624-2019
OI Uchio, Ryusei/0000-0001-5924-4534
FU CRO company (CPCC Co., Ltd., Tokyo, Japan)
FX This study received no external funding and was conducted by a CRO
   company (CPCC Co., Ltd., Tokyo, Japan) under financial support from
   HouseWellness Foods Corp.
CR Aggarwal BB, 2013, MOL NUTR FOOD RES, V57, P1529, DOI 10.1002/mnfr.201200838
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Amalraj Augustine, 2017, J Tradit Complement Med, V7, P205, DOI 10.1016/j.jtcme.2016.05.005
   Anandakumar Senthilkumar, 2014, [Journal of the Korean Society of Food Science and Nutrition, 한국식품영양과학회지], V43, P612
   [Anonymous], 2017, Pharmacol Treat, DOI DOI 10.3390/NU10030281
   [Anonymous], 2009, Statistical methods for psychology
   [Anonymous], 2015, Juntendo Medical Journal, DOI [10.14789/jmj.61.517, DOI 10.14789/JMJ.61.517]
   [Anonymous], BRIC VIEW
   Arima H, 2008, ARTERIOSCL THROM VAS, V28, P1385, DOI 10.1161/ATVBAHA.107.157164
   Babaeian M, 2017, IRAN RED CRESCENT ME, V19, DOI 10.5812/ircmj.34538
   Bogdanski P, 2012, NUTR RES, V32, P421, DOI 10.1016/j.nutres.2012.05.007
   Boix-Castejón M, 2018, FOOD FUNCT, V9, P3173, DOI [10.1039/c8fo00367j, 10.1039/C8FO00367J]
   Calder PC, 2017, AGEING RES REV, V40, P95, DOI 10.1016/j.arr.2017.09.001
   Childs E, 2014, FRONT PHYSIOL, V5, DOI 10.3389/fphys.2014.00161
   Cho HJ, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.23
   Cho HJ, 2013, PSYCHOL MED, V43, P1773, DOI 10.1017/S0033291712002437
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   Christian LM, 2013, PSYCHOSOM MED, V75, P658, DOI 10.1097/PSY.0b013e31829bbc89
   Corpas R, 2018, J PINEAL RES, V65, DOI 10.1111/jpi.12515
   Fernandes IMD, 2018, J EXERC REHABIL, V14, P168, DOI 10.12965/jer.1836070.035
   DellaGioia N, 2013, BRAIN BEHAV IMMUN, V31, P197, DOI 10.1016/j.bbi.2012.10.008
   Devaraj S, 2006, AM J PHYSIOL-HEART C, V291, pH1170, DOI 10.1152/ajpheart.00150.2006
   Devaraj S, 2011, ARTERIOSCL THROM VAS, V31, P1397, DOI 10.1161/ATVBAHA.111.225508
   Doi Y, 2005, DIABETES CARE, V28, P2497, DOI 10.2337/diacare.28.10.2497
   Faul F, 2007, BEHAV RES METHODS, V39, P175, DOI 10.3758/BF03193146
   Ferguson JF, 2014, MOL NUTR FOOD RES, V58, P601, DOI 10.1002/mnfr.201300368
   Fffff K.F., 2010, FFFBMC MED, V8, DOI [10.1186/1741-7015-8-18ffff, DOI 10.1186/1741-7015-8-18FFFF]
   Fukuhara S, 1998, J CLIN EPIDEMIOL, V51, P1037, DOI 10.1016/S0895-4356(98)00095-X
   Fukuhara S, 1998, J CLIN EPIDEMIOL, V51, P1045, DOI 10.1016/S0895-4356(98)00096-1
   Garvin P, 2016, QUAL LIFE RES, V25, P213, DOI 10.1007/s11136-015-1068-6
   Gumina Stefano, 2011, Musculoskelet Surg, V95 Suppl 1, pS37, DOI 10.1007/s12306-011-0121-z
   Heuchert J., 2012, Profile of Mood States, V2nd
   Heuchert J.P., 2015, POMS 2 Japanese version manual
   Ibironke G. F., 2013, African Journal of Biomedical Research, V16, P193
   Iqbal F, 2017, BRIT J PHARMACOL, V174, P3986, DOI 10.1111/bph.13743
   Iso H, 2012, J ATHEROSCLER THROMB, V19, P756
   León-Pedroza JI, 2015, CIR CIR, V83, P543, DOI 10.1016/j.circir.2015.05.041
   Kawasaki K, 2018, BIOSCI BIOTECH BIOCH, V82, P2109, DOI 10.1080/09168451.2018.1511366
   Kawasaki K, 2018, BIOSCI MICROB FOOD H, V37, P25, DOI 10.12938/bmfh.17-020
   Kawasaki K, 2015, BIOSCI BIOTECH BIOCH, V79, P1654, DOI 10.1080/09168451.2015.1039480
   Kell G, 2017, COMPLEMENT THER MED, V33, P58, DOI 10.1016/j.ctim.2017.06.001
   Kim JE, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/5160293
   Kolb H, 2010, DIABETOLOGIA, V53, P10, DOI 10.1007/s00125-009-1573-7
   Komulainen P, 2007, AGE AGEING, V36, P443, DOI 10.1093/ageing/afm051
   Kristjánsdóttir J, 2011, SCAND J CARING SCI, V25, P262, DOI 10.1111/j.1471-6712.2010.00821.x
   Kumar A, 2008, PHYTOMEDICINE, V15, P577, DOI 10.1016/j.phymed.2008.02.003
   Kushner I, 2010, ARTHRIT CARE RES, V62, P442, DOI 10.1002/acr.20052
   Lacourt TE, 2018, FRONT BEHAV NEUROSCI, V12, DOI 10.3389/fnbeh.2018.00078
   Lasselin J, 2014, NEUROIMMUNOMODULAT, V21, P95, DOI 10.1159/000356535
   Li Y, 2014, INT J ONCOL, V44, P505, DOI 10.3892/ijo.2013.2184
   Liu B, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0142382
   Liu LL, 2014, MEDIAT INFLAMM, V2014, DOI 10.1155/2014/418185
   Liukkonen T., 2011, LOW GRADE INFLAMMATI
   Matura LA, 2015, ANN AM THORAC SOC, V12, P370, DOI 10.1513/AnnalsATS.201410-463OC
   MEHRA K S, 1984, Tokai Journal of Experimental and Clinical Medicine, V9, P27
   Miyata S, 2015, SLEEP BIOL RHYTHMS, V13, P387, DOI 10.1111/sbr.12130
   Mizoguchi M, 2011, JACC-CARDIOVASC IMAG, V4, P1110, DOI 10.1016/j.jcmg.2011.08.007
   Nada AS, 2012, CAN J PHYSIOL PHARM, V90, P415, DOI [10.1139/Y2012-005, 10.1139/y2012-005]
   Netea MG, 2017, NAT IMMUNOL, V18, P826, DOI 10.1038/ni.3790
   Oriowo MA, 2015, MED PRIN PRACT, V24, P29, DOI 10.1159/000356380
   Otani T, 2006, CANCER EPIDEM BIOMAR, V15, P690, DOI 10.1158/1055-9965.EPI-05-0708
   Paschalis V, 2016, EUR J NUTR, V55, P45, DOI 10.1007/s00394-014-0821-x
   Ridker PM, 2001, CIRCULATION, V103, P1813, DOI 10.1161/01.CIR.103.13.1813
   Ridker PM, 1997, NEW ENGL J MED, V336, P973, DOI 10.1056/NEJM199704033361401
   Rothwell PM, 2012, LANCET, V379, P1602, DOI 10.1016/S0140-6736(11)61720-0
   Seiler A, 2018, J PSYCHOSOM RES, V112, P40, DOI 10.1016/j.jpsychores.2018.06.010
   Sengupta Mahuya, 2011, Asian Pacific Journal of Tropical Biomedicine, V1, P193, DOI 10.1016/S2221-1691(11)60026-9
   Shimura T, 2012, ANTICANCER RES, V32, P491
   Shin HS, 2014, J ETHNOPHARMACOL, V153, P142, DOI 10.1016/j.jep.2014.01.039
   Shiwaku K, 2004, INT J OBESITY, V28, P152, DOI 10.1038/sj.ijo.0802486
   Silvestro A, 2005, THROMB HAEMOSTASIS, V93, P559, DOI 10.1160/TH04-07-0440
   Sun DI, 2008, INT IMMUNOPHARMACOL, V8, P1272, DOI 10.1016/j.intimp.2008.05.006
   Sung KC, 2006, INT J CARDIOL, V107, P338, DOI 10.1016/j.ijcard.2005.03.045
   Tamakoshi K, 2003, INT J OBESITY, V27, P443, DOI 10.1038/sj.ijo.0802260
   Tao QS, 2018, JAMA NETW OPEN, V1, DOI 10.1001/jamanetworkopen.2018.3597
   Testa MA, 1996, NEW ENGL J MED, V334, P835, DOI 10.1056/NEJM199603283341306
   Uchio R, 2018, J NUTR SCI, V7, DOI 10.1017/jns.2018.27
   Vasileva Liliya V, 2017, Folia Med (Plovdiv), V59, P443, DOI 10.1515/folmed-2017-0046
   Yu ZF, 2002, J ETHNOPHARMACOL, V83, P161, DOI 10.1016/S0378-8741(02)00211-8
NR 79
TC 26
Z9 27
U1 0
U2 14
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2019
VL 11
IS 8
AR 1822
DI 10.3390/nu11081822
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA IV8HH
UT WOS:000484506000126
PM 31394768
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Asih, PR
   Tegg, ML
   Sohrabi, H
   Carruthers, M
   Gandy, SE
   Saad, F
   Verdile, G
   Ittner, LM
   Martins, RN
AF Asih, Prita R.
   Tegg, Michelle L.
   Sohrabi, Hamid
   Carruthers, Malcolm
   Gandy, Samuel E.
   Saad, Farid
   Verdile, Giuseppe
   Ittner, Lars M.
   Martins, Ralph N.
TI Multiple Mechanisms Linking Type 2 Diabetes and Alzheimer's Disease:
   Testosterone as a Modifier
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Review
DE Alzheimer's disease; men; testosterone; type-2 diabetes; women
ID C-REACTIVE PROTEIN; INSULIN-DEGRADING ENZYME; ANDROGEN-DEPRIVATION
   THERAPY; SEX STEROID-HORMONES; APOLIPOPROTEIN-E GENOTYPE;
   GROWTH-FACTOR-I; METABOLIC SYNDROME; OXIDATIVE STRESS; NEUROTROPHIC
   FACTOR; REPLACEMENT THERAPY
AB Evidence in support of links between type-2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) has increased considerably in recent years. AD pathological hallmarks include the accumulation of extracellular amyloid-beta(A beta) and intracellular hyperphosphorylated tau in the brain, which are hypothesized to promote inflammation, oxidative stress, and neuronal loss. T2DM exhibits many AD pathological features, including reduced brain insulin uptake, lipid dysregulation, inflammation, oxidative stress, and depression; T2DM has also been shown to increase AD risk, and with increasing age, the prevalence of both conditions increases. In addition, amylin deposition in the pancreas is more common in AD than in normal aging, and although there is no significant increase in cerebral A beta deposition in T2DM, the extent of A beta accumulation in AD correlates withT2DMduration. Given these similarities and correlations, there may be common underlying mechanism(s) that predispose to both T2DM and AD. In other studies, an age-related gradual loss of testosterone and an increase in testosterone resistance has been shown in men; low testosterone levels can also occur in women. In this review, we focus on the evidence for low testosterone levels contributing to an increased risk of T2DM and AD, and the potential of testosterone treatment in reducing this risk in both men and women. However, such testosterone treatment may need to be long-term, and would need regular monitoring to maintain testosterone at physiological levels. It is possible that a combination of testosterone therapy together with a healthy lifestyle approach, including improved diet and exercise, may significantly reduce AD risk.
C1 [Asih, Prita R.; Ittner, Lars M.] Univ New South Wales, Sch Med Sci, Dementia Res Unit, Dept Anat, Sydney, NSW, Australia.
   [Asih, Prita R.; Martins, Ralph N.] KaRa Inst Neurol Dis, Sydney, NSW, Australia.
   [Tegg, Michelle L.; Sohrabi, Hamid; Martins, Ralph N.] Edith Cowan Univ, Sch Med & Hlth Sci, Perth, WA, Australia.
   [Sohrabi, Hamid; Verdile, Giuseppe; Martins, Ralph N.] Australian Alzheimers Res Fdn, Perth, WA, Australia.
   [Sohrabi, Hamid; Martins, Ralph N.] Macquarie Univ, Dept Biomed Sci, Sydney, NSW, Australia.
   [Sohrabi, Hamid; Martins, Ralph N.] Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA, Australia.
   [Carruthers, Malcolm] Ctr Mens Hlth, London, England.
   [Gandy, Samuel E.] Icahn Sch Med Mt Sinai, Dept Neurol, One Gustave L Levy Pl, New York, NY 10029 USA.
   [Gandy, Samuel E.] Icahn Sch Med Mt Sinai, Dept Psychiat, One Gustave L Levy Pl, New York, NY 10029 USA.
   [Gandy, Samuel E.] Icahn Sch Med Mt Sinai, Alzheimers Dis Res Ctr, One Gustave L Levy Pl, New York, NY 10029 USA.
   [Saad, Farid] Bayer Pharma AG, Global Med Affairs Androl, Berlin, Germany.
   [Saad, Farid] Gulf Med Univ, Sch Med, Ajman, U Arab Emirates.
   [Verdile, Giuseppe] Curtin Univ Technol, Sch Biomed Sci, Bentley, WA, Australia.
   [Ittner, Lars M.] Neurosci Res Australia, Sydney, NSW, Australia.
C3 University of New South Wales Sydney; KaRa Minds; Edith Cowan
   University; Macquarie University; University of Western Australia; Icahn
   School of Medicine at Mount Sinai; Icahn School of Medicine at Mount
   Sinai; Icahn School of Medicine at Mount Sinai; Bayer AG; Bayer
   Healthcare Pharmaceuticals; Curtin University; Neuroscience Research
   Australia
RP Martins, RN (corresponding author), Edith Cowan Univ, Ctr Excellence Alzheimers Dis Res & Care, Sch Med Sci, Joondalup, Australia.
EM r.martins@ecu.edu.au
RI Saad, Farid/AAW-2694-2020; Asih, Prita/ABE-6951-2020; Sohrabi, Hamid
   Reza/D-2744-2013
OI Ittner, Lars/0000-0001-6738-3825; Martins, Ralph/0000-0002-4828-9363;
   Verdile, Giuseppe/0000-0003-2475-0124; Sohrabi, Hamid
   Reza/0000-0001-8017-8682; Tegg, Michelle/0000-0003-4086-4156; Asih,
   Prita Riana/0000-0002-1973-9628
CR Ahlskog JE, 2011, MAYO CLIN PROC, V86, P876, DOI 10.4065/mcp.2011.0252
   Akita K, 2013, EUR J PHARMACOL, V720, P107, DOI 10.1016/j.ejphar.2013.10.042
   Akiyama H, 2000, NEUROBIOL AGING, V21, P383, DOI 10.1016/S0197-4580(00)00124-X
   Akter K, 2011, BRIT J CLIN PHARMACO, V71, P365, DOI 10.1111/j.1365-2125.2010.03830.x
   Allan CA, 2014, ASIAN J ANDROL, V16, P232, DOI 10.4103/1008-682X.122589
   Allen KM, 2015, BMC NEUROSCI, V16, DOI 10.1186/s12868-015-0142-x
   Anthopoulos PG, 2010, MOL GENET METAB, V100, P283, DOI 10.1016/j.ymgme.2010.03.008
   Arnetz L, 2014, DIABET METAB SYND OB, V7, P409, DOI 10.2147/DMSO.S51301
   ASHTON WS, 1995, ANN CLIN LAB SCI, V25, P381
   Atwi S, 2016, NEUROSCIENTIST, V22, P46, DOI 10.1177/1073858414558065
   Balsamo S, 2013, INT J GEN MED, V6, P387, DOI 10.2147/IJGM.S35315
   Bassil Nazem, 2009, Ther Clin Risk Manag, V5, P427
   Bennett RG, 2000, J BIOL CHEM, V275, P36621, DOI 10.1074/jbc.M006170200
   Bertoldo MJ, 2015, FRONT NEUROSCI-SWITZ, V9, DOI 10.3389/fnins.2015.00235
   Bertram S, 2016, ENDOCRINE, V53, P350, DOI 10.1007/s12020-016-0976-8
   Bhasin S, 2007, J CLIN ENDOCR METAB, V92, P1049, DOI 10.1210/jc.2006-2060
   Bhatia V, 2006, DIABETES CARE, V29, P2289, DOI 10.2337/dc06-0637
   Bitoska Iskra, 2016, Open Access Maced J Med Sci, V4, P83, DOI 10.3889/oamjms.2016.024
   Blázquez E, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00161
   Boden G, 2008, ENDOCRIN METAB CLIN, V37, P635, DOI 10.1016/j.ecl.2008.06.007
   Borgquist A, 2015, AM J PHYSIOL-ENDOC M, V308, pE482, DOI 10.1152/ajpendo.00421.2014
   Boyanov M A, 2003, Aging Male, V6, P1
   Buckler HM, 1998, CLIN ENDOCRINOL, V49, P173, DOI 10.1046/j.1365-2265.1998.00525.x
   Caccamo A, 2005, NEUROBIOL AGING, V26, P645, DOI 10.1016/j.neurobiolaging.2004.06.013
   CAGNACCI A, 1992, J CLIN ENDOCR METAB, V74, P1396, DOI 10.1210/jc.74.6.1396
   Cai ZY, 2012, NEUROMOL MED, V14, P1, DOI 10.1007/s12017-012-8173-2
   Caronia LM, 2013, CLIN ENDOCRINOL, V78, P291, DOI 10.1111/j.1365-2265.2012.04486.x
   Carro E, 2000, J NEUROSCI, V20, P2926
   Carruthers M, 2015, AGING MALE, V18, P217, DOI 10.3109/13685538.2015.1048218
   Vieira JSBC, 2011, INT J EXP PATHOL, V92, P272, DOI 10.1111/j.1365-2613.2011.00772.x
   Cheang WS, 2011, CARDIOVASC RES, V92, P267, DOI 10.1093/cvr/cvr233
   Chiu SL, 2008, NEURON, V58, P708, DOI 10.1016/j.neuron.2008.04.014
   Cho DY, 2017, ASIAN J ANDROL, V19, P602, DOI 10.4103/1008-682X.184269
   Cojocaru Inimioara Mihaela, 2011, Rom J Intern Med, V49, P55
   Colberg SR, 2010, DIABETES CARE, V33, pe147
   Cole AR, 2007, NEUROSCI BIOBEHAV R, V31, P1046, DOI 10.1016/j.neubiorev.2007.04.004
   Cole SL, 2007, CURR GENOMICS, V8, P509, DOI 10.2174/138920207783769512
   Cole SL, 2008, CURR ALZHEIMER RES, V5, P100, DOI 10.2174/156720508783954758
   Cook DG, 2003, AM J PATHOL, V162, P313, DOI 10.1016/S0002-9440(10)63822-9
   Corbould A, 2008, DIABETES-METAB RES, V24, P520, DOI 10.1002/dmrr.872
   Corona G, 2011, J SEX MED, V8, P272, DOI 10.1111/j.1743-6109.2010.01991.x
   Corrales JJ, 2006, J ENDOCRINOL, V189, P595, DOI 10.1677/joe.1.06779
   Costes S, 2014, CELL METAB, V20, P201, DOI 10.1016/j.cmet.2014.07.016
   Cotman CW, 2007, TRENDS NEUROSCI, V30, P464, DOI 10.1016/j.tins.2007.06.011
   Coughlan KA, 2014, DIABET METAB SYND OB, V7, P241, DOI 10.2147/DMSO.S43731
   Craft S, 1999, NEUROENDOCRINOLOGY, V70, P146, DOI 10.1159/000054469
   Craft S, 1998, NEUROLOGY, V50, P164, DOI 10.1212/WNL.50.1.164
   CROSS DAE, 1995, NATURE, V378, P785, DOI 10.1038/378785a0
   Cunningham RL, 2014, J ALZHEIMERS DIS, V40, P563, DOI 10.3233/JAD-131994
   Davey RA, 2006, CALCIFIED TISSUE INT, V78, P398, DOI 10.1007/s00223-005-0286-2
   Davis SR, 2014, CLIN ENDOCRINOL, V81, P621, DOI 10.1111/cen.12459
   Davison SL, 2005, J CLIN ENDOCR METAB, V90, P3847, DOI 10.1210/jc.2005-0212
   de la Monte Suzanne M, 2008, J Diabetes Sci Technol, V2, P1101
   De Leo V, 2004, Minerva Ginecol, V56, P53
   Ding EL, 2006, JAMA-J AM MED ASSOC, V295, P1288, DOI 10.1001/jama.295.11.1288
   Dislich B, 2012, FRONT PHYSIOL, V3, DOI 10.3389/fphys.2012.00008
   Dominguez D, 2005, J BIOL CHEM, V280, P30797, DOI 10.1074/jbc.M505249200
   Du J, 2009, NEUROSCI LETT, V464, P140, DOI 10.1016/j.neulet.2009.07.032
   El-Lebedy D, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-016-0329-1
   Engelhart MJ, 2004, ARCH NEUROL-CHICAGO, V61, P668, DOI 10.1001/archneur.61.5.668
   Farris W, 2003, P NATL ACAD SCI USA, V100, P4162, DOI 10.1073/pnas.0230450100
   Farris W, 2004, AM J PATHOL, V164, P1425, DOI 10.1016/S0002-9440(10)63229-4
   Fernando SM, 2010, ENDOCRINOLOGY, V151, P3125, DOI 10.1210/en.2010-0018
   Flores MBS, 2006, DIABETES, V55, P2554, DOI 10.2337/db05-1622
   Folli F, 2011, CURR DIABETES REV, V7, P313, DOI 10.2174/157339911797415585
   Fuller SJ, 2007, J ALZHEIMERS DIS, V12, P129
   Gandy S, 2001, JAMA-J AM MED ASSOC, V285, P2195, DOI 10.1001/jama.285.17.2195-a
   Gasparini L, 2001, J NEUROSCI, V21, P2561, DOI 10.1523/JNEUROSCI.21-08-02561.2001
   Gasparini L, 2002, TRENDS PHARMACOL SCI, V23, P288, DOI 10.1016/S0165-6147(02)02037-0
   George S, 2013, ACS CHEM NEUROSCI, V4, P1537, DOI 10.1021/cn400133s
   Giltay EJ, 2008, ANDROLOGIA, V40, P398, DOI 10.1111/j.1439-0272.2008.00873.x
   Glaser R, 2013, MATURITAS, V74, P230, DOI 10.1016/j.maturitas.2013.01.003
   Golden E, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010099
   Grossmann M, 2008, J CLIN ENDOCR METAB, V93, P1834, DOI 10.1210/jc.2007-2177
   Grossmann M, 2015, CLIN ENDOCRINOL, V83, P344, DOI 10.1111/cen.12664
   Grossmann M, 2014, J ENDOCRINOL, V220, pR37, DOI 10.1530/JOE-13-0393
   Grossmann M, 2011, J CLIN ENDOCR METAB, V96, P2341, DOI 10.1210/jc.2011-0118
   Guan H, 2012, DIABETOLOGIA, V55, P2989, DOI 10.1007/s00125-012-2678-y
   Haidar A, 2007, AGING MALE, V10, P189, DOI 10.1080/13685530701653538
   Haider A, 2014, INT J ENDOCRINOL, V2014, DOI 10.1155/2014/683515
   Hajszan T, 2008, HORM BEHAV, V53, P638, DOI 10.1016/j.yhbeh.2007.12.007
   Hamson DK, 2013, ENDOCRINOLOGY, V154, P3294, DOI 10.1210/en.2013-1129
   Hanson AJ, 2016, DEMENT GER COGN D EX, V6, P78, DOI 10.1159/000444079
   Hanson AJ, 2013, JAMA NEUROL, V70, P972, DOI 10.1001/jamaneurol.2013.396
   Haring R, 2012, J CLIN ENDOCR METAB, V97, P408, DOI 10.1210/jc.2011-2134
   HAVRANKOVA J, 1979, J CLIN INVEST, V64, P636, DOI 10.1172/JCI109504
   Heufelder AE, 2009, J ANDROL, V30, P726, DOI 10.2164/jandrol.108.007005
   Hill RA, 2012, J NEUROENDOCRINOL, V24, P774, DOI 10.1111/j.1365-2826.2012.02277.x
   HOBBS CJ, 1993, J CLIN ENDOCR METAB, V77, P776, DOI 10.1210/jc.77.3.776
   Hoffmeister A, 2013, OBESITY, V21, pE626, DOI 10.1002/oby.20482
   Hogervorst E, 2002, INT J GERIATR PSYCH, V17, P938, DOI 10.1002/gps.714
   Hooper C, 2008, J NEUROCHEM, V104, P1433, DOI 10.1111/j.1471-4159.2007.05194.x
   Horii N, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0165689
   Hotamisligil GS, 2003, INT J OBESITY, V27, pS53, DOI 10.1038/sj.ijo.0802502
   Huang G, 2015, J ENDOCRINOL INVEST, V38, P455, DOI 10.1007/s40618-014-0213-3
   Huang T, 2014, SCAND J MED SCI SPOR, V24, P1, DOI 10.1111/sms.12069
   Hull M, 1996, BEHAV BRAIN RES, V78, P37, DOI 10.1016/0166-4328(95)00213-8
   Intlekofer KA, 2013, NEUROBIOL DIS, V57, P47, DOI 10.1016/j.nbd.2012.06.011
   Janson J, 2004, DIABETES, V53, P474, DOI 10.2337/diabetes.53.2.474
   Jayaraman A, 2014, CURR DIABETES REP, V14, DOI 10.1007/s11892-014-0476-2
   Jia JX, 2016, J TOXICOL ENV HEAL A, V79, P849, DOI 10.1080/15287394.2016.1193113
   Kang Eun Bum, 2014, J Exerc Nutrition Biochem, V18, P89, DOI 10.5717/jenb.2014.18.1.89
   Kapoor D, 2007, EUR J ENDOCRINOL, V156, P595, DOI 10.1530/EJE-06-0737
   Kapoor D, 2006, EUR J ENDOCRINOL, V154, P899, DOI 10.1530/eje.1.02166
   Kapoor D, 2007, DIABETES CARE, V30, P911, DOI 10.2337/dc06-1426
   Ke HC, 2011, BRAIN RES, V1403, P1, DOI 10.1016/j.brainres.2011.05.056
   Keating NL, 2006, J CLIN ONCOL, V24, P4448, DOI 10.1200/JCO.2006.06.2497
   Keating NL, 2012, J NATL CANCER I, V104, P1518, DOI 10.1093/jnci/djs376
   Kemppainen J, 2005, J PHYSIOL-LONDON, V568, P323, DOI 10.1113/jphysiol.2005.091355
   Kim C, 2014, CURR CARDIOL REP, V16, DOI 10.1007/s11886-014-0467-6
   Kivipelto M, 2013, ALZHEIMERS DEMENT, V9, P657, DOI 10.1016/j.jalz.2012.09.012
   Krabbe KS, 2007, DIABETOLOGIA, V50, P431, DOI 10.1007/s00125-006-0537-4
   Krauss RM, 2004, DIABETES CARE, V27, P1496, DOI 10.2337/diacare.27.6.1496
   Kravitz BA, 2009, ALZHEIMERS DEMENT, V5, P318, DOI 10.1016/j.jalz.2009.04.1230
   Kristiansen OP, 2005, DIABETES, V54, pS114, DOI 10.2337/diabetes.54.suppl_2.S114
   Lage MJ, 2007, UROLOGY, V70, P1104, DOI 10.1016/j.urology.2007.08.012
   Lambert CP, 2003, J GERONTOL A-BIOL, V58, P165
   Lee CH, 2005, ENDOCR RES, V31, P139, DOI 10.1080/07435800500320653
   Leranth C, 2004, J NEUROSCI, V24, P495, DOI 10.1523/JNEUROSCI.4516-03.2004
   Leuner B, 2004, MOL NEUROBIOL, V29, P117, DOI 10.1385/MN:29:2:117
   Li R, 2013, MOL NEUROBIOL, V47, P857, DOI 10.1007/s12035-012-8377-3
   Liang KY, 2010, ANN NEUROL, V68, P311, DOI 10.1002/ana.22096
   Lightfoot JT, 2008, INT J BIOL SCI, V4, P126
   Liu M, 2010, MINERVA ENDOCRINOL, V35, P127
   Liu Y, 2011, J ENDOCRINOL INVEST, V34, P26, DOI [10.1007/BF03346691, 10.3275/6995]
   Lovell MA, 2004, J ALZHEIMERS DIS, V6, P659
   Lucas SJE, 2015, J CEREBR BLOOD F MET, V35, P902, DOI 10.1038/jcbfm.2015.49
   Luo Y, 2001, NAT NEUROSCI, V4, P231, DOI 10.1038/85059
   Lv WS, 2016, MOL NEUROBIOL, V53, P2679, DOI 10.1007/s12035-015-9315-y
   MacPherson REK, 2015, J APPL PHYSIOL, V119, P1097, DOI 10.1152/japplphysiol.00299.2015
   Maggio M, 2005, J Endocrinol Invest, V28, P116
   Maggio M, 2006, J GERONTOL A-BIOL, V61, P575, DOI 10.1093/gerona/61.6.575
   Maher PA, 2009, EXPERT REV NEUROTHER, V9, P617, DOI [10.1586/ern.09.18, 10.1586/ERN.09.18]
   Malkin CJ, 2004, J CLIN ENDOCR METAB, V89, P3313, DOI 10.1210/jc.2003-031069
   Marin DP, 2010, CELL BIOCHEM FUNCT, V28, P394, DOI 10.1002/cbf.1669
   Martins AR, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-30
   Martins RN, 2016, NAT REV UROL, V13, P188, DOI 10.1038/nrurol.2016.34
   Matsui S, 2013, INT J ENDOCRINOL MET, V11, P65, DOI 10.5812/ijem.5333
   Matthews VB, 2009, DIABETOLOGIA, V52, P1409, DOI 10.1007/s00125-009-1364-1
   Mauvais-Jarvis F, 2015, BIOL SEX DIFFER, V6, DOI 10.1186/s13293-015-0033-y
   McAllister C, 2010, J NEUROSCI, V30, P7326, DOI 10.1523/JNEUROSCI.1180-10.2010
   McInnes KJ, 2012, INT J OBESITY, V36, P982, DOI 10.1038/ijo.2011.172
   Meakin PJ, 2012, BIOCHEM J, V441, P285, DOI 10.1042/BJ20110512
   Mielke MM, 2014, CLIN EPIDEMIOL, V6, P37, DOI 10.2147/CLEP.S37929
   Miller KK, 2004, PSYCHIAT RES-NEUROIM, V132, P197, DOI 10.1016/j.pscychresns.2004.09.003
   Miller TM, 2012, J INVEST MED, V60, P664, DOI 10.2310/JIM.0b013e31824b2de6
   Mitsuhashi K, 2016, ENDOCRINE, V51, P174, DOI 10.1007/s12020-015-0666-y
   Mitsuzuka K, 2016, PROSTATE CANCER P D, V19, P57, DOI 10.1038/pcan.2015.50
   Moffat SD, 2007, NEUROBIOL AGING, V28, P914, DOI 10.1016/j.neurobiolaging.2006.04.001
   Moghetti P, 1996, J CLIN ENDOCR METAB, V81, P952, DOI 10.1210/jc.81.3.952
   Moran C, 2015, NEUROLOGY, V85, P1123, DOI 10.1212/WNL.0000000000001982
   Morford J, 2016, DIALOGUES CLIN NEURO, V18, P415
   Morris JC, 2010, ANN NEUROL, V67, P122, DOI 10.1002/ana.21843
   Muller AP, 2011, HIPPOCAMPUS, V21, P1082, DOI 10.1002/hipo.20822
   Muthusamy T, 2011, MOL CELL BIOCHEM, V352, P35, DOI 10.1007/s11010-011-0737-1
   Muthusamy T, 2009, METABOLISM, V58, P1581, DOI 10.1016/j.metabol.2009.05.010
   Navarro G, 2016, CELL METAB, V23, P837, DOI 10.1016/j.cmet.2016.03.015
   Navarro G, 2015, OBESITY, V23, P713, DOI 10.1002/oby.21033
   Nead KT, 2016, J CLIN ONCOL, V34, P566, DOI 10.1200/JCO.2015.63.6266
   Nohara K, 2014, OBESITY, V22, P1477, DOI 10.1002/oby.20719
   Nunomura A, 2001, J NEUROPATH EXP NEUR, V60, P759, DOI 10.1093/jnen/60.8.759
   O'Bryant SE, 2013, J ALZHEIMERS DIS, V34, P701, DOI 10.3233/JAD-122071
   O'Bryant SE, 2010, J GERIATR PSYCH NEUR, V23, P49, DOI 10.1177/0891988709351832
   Ohno M, 2004, NEURON, V41, P27, DOI 10.1016/S0896-6273(03)00810-9
   Olver TD, 2016, AM J PHYSIOL-HEART C, V310, pH337, DOI 10.1152/ajpheart.00440.2015
   OSULLIVAN AJ, 1995, J CLIN ENDOCR METAB, V80, P1783, DOI 10.1210/jc.80.6.1783
   Ota H, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0029598
   Ott A, 1999, NEUROLOGY, V53, P1937, DOI 10.1212/WNL.53.9.1937
   Panizzon MS, 2010, NEUROLOGY, V75, P874, DOI 10.1212/WNL.0b013e3181f11deb
   Papalia Mary-Anne, 2003, Treat Endocrinol, V2, P77, DOI 10.2165/00024677-200302020-00001
   Papasozomenos SC, 2002, P NATL ACAD SCI USA, V99, P1140, DOI 10.1073/pnas.032646799
   Papasozomenos SC, 1997, P NATL ACAD SCI USA, V94, P6612, DOI 10.1073/pnas.94.13.6612
   Park K, 2009, DIABETES CARE, V32, P1302, DOI 10.2337/dc09-0259
   Parthasarathy C, 2009, CLIN CHIM ACTA, V399, P49, DOI 10.1016/j.cca.2008.09.011
   Peltola V, 1996, ENDOCRINOLOGY, V137, P105, DOI 10.1210/en.137.1.105
   Perreault L, 2008, DIABETES CARE, V31, P1416, DOI 10.2337/dc07-2390
   Pettersson US, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046057
   Pfankuch T, 2005, BRAIN RES, V1053, P88, DOI 10.1016/j.brainres.2005.06.028
   Pickup JC, 1997, DIABETOLOGIA, V40, P1286, DOI 10.1007/s001250050822
   Pike CJ, 2009, FRONT NEUROENDOCRIN, V30, P239, DOI 10.1016/j.yfrne.2009.04.015
   Plucinska K, 2016, DIABETOLOGIA, V59, P1513, DOI 10.1007/s00125-016-3960-1
   POLDERMAN KH, 1994, J CLIN ENDOCR METAB, V79, P265, DOI 10.1210/jc.79.1.265
   Qiu WQ, 2014, FRONT AGING NEUROSCI, V6, DOI 10.3389/fnagi.2014.00186
   Raber J, 2002, J NEUROSCI, V22, P5204, DOI 10.1523/JNEUROSCI.22-12-05204.2002
   Rana K, 2011, AM J PHYSIOL-ENDOC M, V301, pE767, DOI 10.1152/ajpendo.00584.2010
   Rao PM, 2013, NAT REV ENDOCRINOL, V9, P479, DOI 10.1038/nrendo.2013.122
   Rasika S, 1999, NEURON, V22, P53, DOI 10.1016/S0896-6273(00)80678-9
   Rayasam GV, 2009, BRIT J PHARMACOL, V156, P885, DOI 10.1111/j.1476-5381.2008.00085.x
   Refolo LM, 2000, NEUROBIOL DIS, V7, P321, DOI 10.1006/nbdi.2000.0304
   Reger MA, 2006, NEUROBIOL AGING, V27, P451, DOI 10.1016/j.neurobiolaging.2005.03.016
   Riddell Michael, 2009, J Diabetes Sci Technol, V3, P914
   Roberds SL, 2001, HUM MOL GENET, V10, P1317, DOI 10.1093/hmg/10.12.1317
   Rosario ER, 2008, BRAIN RES REV, V57, P444, DOI 10.1016/j.brainresrev.2007.04.012
   Rosario ER, 2011, NEUROBIOL AGING, V32, P604, DOI 10.1016/j.neurobiolaging.2009.04.008
   Rosario ER, 2010, BRAIN RES, V1359, P281, DOI 10.1016/j.brainres.2010.08.068
   Rosario ER., 2004, Jama, V292, P1431, DOI DOI 10.1001/JAMA.292.12.1431-B
   Rösler N, 2001, ACTA NEUROL SCAND, V103, P126, DOI 10.1034/j.1600-0404.2001.103002126.x
   Rubio-Perez Jose Miguel, 2012, ScientificWorldJournal, V2012, P756357, DOI 10.1100/2012/756357
   Ryan SM, 2016, AGEING RES REV, V27, P77, DOI 10.1016/j.arr.2016.03.007
   Saad F, 2009, ARQ BRAS ENDOCRINOL, V53, P901, DOI 10.1590/S0004-27302009000800002
   Saltiel AR, 2001, CELL, V104, P517, DOI 10.1016/S0092-8674(01)00239-2
   Samaan MC, 2015, SCI REP-UK, V5, DOI 10.1038/srep09154
   Sato K, 2016, EXP PHYSIOL, V101, P168, DOI 10.1113/EP085361
   Schmidt R, 2002, ANN NEUROL, V52, P168, DOI 10.1002/ana.10265
   Schubert M, 2004, P NATL ACAD SCI USA, V101, P3100, DOI 10.1073/pnas.0308724101
   Schulz K, 2010, FRONT BEHAV NEUROSCI, V4, DOI 10.3389/fnbeh.2010.00187
   Schwartz MW, 2005, SCIENCE, V307, P375, DOI 10.1126/science.1104344
   Schwingshackl A, 1998, EXP CELL RES, V241, P265, DOI 10.1006/excr.1998.4017
   SEIDELL JC, 1990, METABOLISM, V39, P897, DOI 10.1016/0026-0495(90)90297-P
   SESTI G, 1992, MOL CELL ENDOCRINOL, V86, P111, DOI 10.1016/0303-7207(92)90181-5
   Shah S, 2006, MENOPAUSE, V13, P600, DOI 10.1097/01.gme.0000227333.50867.4e
   Shie FS, 2002, NEUROREPORT, V13, P455, DOI 10.1097/00001756-200203250-00019
   Singer O, 2005, NAT NEUROSCI, V8, P1343, DOI 10.1038/nn1531
   Skogastierna C, 2014, EUR J PREV CARDIOL, V21, P1049, DOI 10.1177/2047487313481755
   Somboonporn W, 2005, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004509.pub2
   Stanworth RD, 2011, CLIN ENDOCRINOL, V74, P624, DOI 10.1111/j.1365-2265.2011.03969.x
   Steen E, 2005, J ALZHEIMERS DIS, V7, P63, DOI 10.3233/jad-2005-7107
   Takeda S, 2010, P NATL ACAD SCI USA, V107, P7036, DOI 10.1073/pnas.1000645107
   Takeuchi M, 2008, CURR PHARM DESIGN, V14, P973, DOI 10.2174/138161208784139693
   Tan RS, 2013, AGING CLIN EXP RES, V25, P343, DOI 10.1007/s40520-013-0049-2
   Tang WJ, 2016, TRENDS ENDOCRIN MET, V27, P24, DOI 10.1016/j.tem.2015.11.003
   Tapia-Rojas C, 2016, BRAIN PATHOL, V26, P62, DOI 10.1111/bpa.12255
   Uchoa MF, 2016, FRONT NEUROENDOCRIN, V43, P60, DOI 10.1016/j.yfrne.2016.09.001
   van de Ree MA, 2003, ATHEROSCLEROSIS, V166, P129, DOI 10.1016/S0021-9150(02)00316-7
   Varlamov Oleg, 2014, Front Endocrinol (Lausanne), V5, P241, DOI 10.3389/fendo.2014.00241
   Verdile G, 2014, MOL PSYCHIATR, V19, P69, DOI 10.1038/mp.2012.147
   Verdile G, 2015, MEDIAT INFLAMM, V2015, DOI 10.1155/2015/105828
   Verdile G, 2015, NEUROBIOL DIS, V84, P22, DOI 10.1016/j.nbd.2015.04.008
   Verghese PB, 2013, P NATL ACAD SCI USA, V110, pE1807, DOI 10.1073/pnas.1220484110
   Verhovshek T, 2013, NEUROSCIENCE, V239, P103, DOI 10.1016/j.neuroscience.2012.10.028
   Verhovshek T, 2013, DEV NEUROBIOL, V73, P587, DOI 10.1002/dneu.22083
   Verhovshek T, 2010, ENDOCRINOLOGY, V151, P253, DOI 10.1210/en.2009-1036
   Vermeulen A, 1999, J CLIN ENDOCR METAB, V84, P3666, DOI 10.1210/jc.84.10.3666
   Volpi E, 2005, DIABETES CARE, V28, P429, DOI 10.2337/diacare.28.2.429
   Wahjoepramono EJ, 2016, CNS NEUROL DISORD-DR, V15, P337, DOI 10.2174/1871527315666151110125704
   Watson GS, 2003, CNS DRUGS, V17, P27, DOI 10.2165/00023210-200317010-00003
   Wierman ME, 2006, J CLIN ENDOCR METAB, V91, P3697, DOI 10.1210/jc.2006-1121
   Wild S, 2004, DIABETES CARE, V27, P1047, DOI 10.2337/diacare.27.5.1047
   Wildsmith KR, 2013, ALZHEIMERS RES THER, V5, DOI 10.1186/alzrt187
   Xu J, 2016, CURR ALZHEIMER RES, V13, P215, DOI 10.2174/1567205013666151218145752
   Yamada E, 2010, FUTURE MED CHEM, V2, P1785, DOI [10.4155/fmc.10.264, 10.4155/FMC.10.264]
   Yanar K, 2015, REJUV RES, V18, P299, DOI 10.1089/rej.2014.1640
   Yang Y, 2013, J ALZHEIMERS DIS, V33, P329, DOI 10.3233/JAD-2012-121294
   Yao MZ, 2008, J NEUROCHEM, V105, P2477, DOI 10.1111/j.1471-4159.2008.05341.x
   Yarchoan M, 2013, J NEUROL SCI, V333, P9, DOI 10.1016/j.jns.2013.05.028
   Yialamas MA, 2007, J CLIN ENDOCR METAB, V92, P4254, DOI 10.1210/jc.2007-0454
   Yoshizawa A, 2000, J CLIN ENDOCR METAB, V85, P1627, DOI 10.1210/jc.85.4.1627
   Yu J, 2010, ENDOCRINOLOGY, V151, P1822, DOI 10.1210/en.2009-1048
   Zang H, 2006, FERTIL STERIL, V86, P136, DOI 10.1016/j.fertnstert.2005.12.039
   Zhu H, 2015, MOL PSYCHIATR, V20, P232, DOI 10.1038/mp.2014.17
NR 250
TC 27
Z9 30
U1 1
U2 21
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2017
VL 59
IS 2
BP 445
EP 466
DI 10.3233/JAD-161259
PG 22
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA FA9ZT
UT WOS:000405805400007
PM 28655134
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Thomson, EM
   Pal, S
   Guénette, J
   Wade, MG
   Atlas, E
   Holloway, AC
   Williams, A
   Vincent, R
AF Thomson, Errol M.
   Pal, Shinjini
   Guenette, Josee
   Wade, Michael G.
   Atlas, Ella
   Holloway, Alison C.
   Williams, Andrew
   Vincent, Renaud
TI Ozone Inhalation Provokes Glucocorticoid-Dependent and -Independent
   Effects on Inflammatory and Metabolic Pathways
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE air pollution; ozone; glucocorticoid; stress response;
   hypothalamic-pituitary-adrenal (HPA) axis; systemic effects;
   inflammation; metabolic effects
ID EMERGENCY-DEPARTMENT VISITS; INHALED PARTICULATE MATTER; AMBIENT
   AIR-POLLUTION; LONG-TERM EXPOSURE; INSULIN-RESISTANCE; LUNG INJURY;
   STRESS; GENE; YOUNG; RESPONSIVENESS
AB Growing evidence implicates air pollutants in adverse health effects beyond respiratory and cardiovascular disease, including metabolic impacts (diabetes, metabolic syndrome, obesity) and neurological/neurobehavioral outcomes (neurodegenerative disease, cognitive decline, perceived stress, depression, suicide). We have shown that inhalation of particulate matter or ozone activates the hypothalamic-pituitary-adrenal axis in rats and increases plasma levels of the glucocorticoid corticosterone. To investigate the role of corticosterone in mediating inflammatory and metabolic effects of pollutant exposure, in this study male Fischer-344 rats were administered the 11 beta-hydroxylase inhibitor metyrapone (0, 50, 150 mg/kg body weight) and exposed by nose-only inhalation for 4h to air or 0.8ppm ozone. Ozone inhalation provoked a 2-fold increase in plasma corticosterone, an effect blocked by metyrapone, but did not alter epinephrine levels. Inhibition of corticosterone production was associated with increased inflammatory signaling in the lungs and plasma in response to ozone, consistent with a role for glucocorticoids in limiting local and systemic inflammatory responses. Effects of ozone on insulin and glucagon, but not ghrelin or plasminogen activator inhibitor-1, were modified by metyrapone, revealing glucocorticoid-dependent and - independent effects on circulating metabolic and hemostatic factors. Several immunosuppressive and metabolic impacts of ozone in the lungs, heart, liver, kidney, and spleen were blocked by metyrapone and reproduced through exogenous administration of corticosterone (10 mg/kg body weight), demonstrating glucocorticoid-dependent effects in target tissues. Our results support involvement of endogenous glucocorticoids in ozone-induced inflammatory and metabolic effects, providing insight into potential biological mechanisms underlying health impacts and susceptibility.
C1 [Thomson, Errol M.; Pal, Shinjini; Guenette, Josee; Wade, Michael G.; Atlas, Ella; Williams, Andrew; Vincent, Renaud] Hlth Canada, Environm Hlth Sci & Res Bur, Ottawa, ON K1A 0K9, Canada.
   [Holloway, Alison C.] McMaster Univ, Dept Obstet & Gynecol, Hamilton, ON L8N 3Z5, Canada.
C3 Health Canada; McMaster University
RP Thomson, EM (corresponding author), Hlth Canada, Hazard Identificat Div, Inhalat Toxicol Lab, Environm Hlth Sci & Res Bur, 0802B Tunneys Pasture, Ottawa, ON K1A 0K9, Canada.
EM errol.thomson@hc-sc.gc.ca
RI williams, anthony/HPE-7348-2023
OI Wade, Michael/0000-0002-7331-3839; Thomson, Errol/0000-0003-1295-5384;
   Williams, Andrew/0000-0002-7637-7686
FU Health Canada (Clean Air Regulatory Agenda) [810504]
FX This work was supported by Health Canada (Clean Air Regulatory Agenda,
   project 810504).
CR Aibo DI, 2010, TOXICOL SCI, V115, P267, DOI 10.1093/toxsci/kfq034
   Alessi MC, 2006, ARTERIOSCL THROM VAS, V26, P2200, DOI 10.1161/01.ATV.0000242905.41404.68
   Allen JL, 2013, ENVIRON HEALTH PERSP, V121, P32, DOI [10.1289/ehp.1205505, 10.1289/ehp.121-a32]
   Anagnostis P, 2009, J CLIN ENDOCR METAB, V94, P2692, DOI 10.1210/jc.2009-0370
   Andersen ZJ, 2012, DIABETES CARE, V35, P92, DOI 10.2337/dc11-1155
   [Anonymous], Statistical Inference
   Ayroldi E, 2009, FASEB J, V23, P3649, DOI 10.1096/fj.09-134684
   Bass V, 2013, TOXICOL APPL PHARM, V273, P551, DOI 10.1016/j.taap.2013.09.029
   Brook RD, 2008, J OCCUP ENVIRON MED, V50, P32, DOI 10.1097/JOM.0b013e31815dba70
   Brook RD, 2013, DIABETES CARE, V36, P3313, DOI 10.2337/dc12-2189
   Calderón-Garcidueñas L, 2015, ENVIRON RES, V140, P579, DOI 10.1016/j.envres.2015.05.012
   Carsia RV, 1997, ENDOCRINE, V7, P377, DOI 10.1007/BF02801333
   Chen DL, 2011, J CELL PHYSIOL, V226, P2469, DOI 10.1002/jcp.22725
   Chen JC, 2009, NEUROTOXICOLOGY, V30, P231, DOI 10.1016/j.neuro.2008.12.011
   Chrousos GP, 2009, ANN NY ACAD SCI, V1179, P153, DOI 10.1111/j.1749-6632.2009.04988.x
   Chuang KJ, 2007, AM J RESP CRIT CARE, V176, P370, DOI 10.1164/rccm.200611-1627OC
   Clougherty JE, 2007, ENVIRON HEALTH PERSP, V115, P1140, DOI 10.1289/ehp.9863
   de Haij S, 2003, J BIOL CHEM, V278, P5091, DOI 10.1074/jbc.M209836200
   Devlin RB, 2012, CIRCULATION, V126, P104, DOI 10.1161/CIRCULATIONAHA.112.094359
   DHABHAR FS, 1993, BRAIN RES, V616, P89, DOI 10.1016/0006-8993(93)90196-T
   Dye JA, 1999, INHAL TOXICOL, V11, P1015
   Gackière F, 2011, J NEUROCHEM, V117, P961, DOI 10.1111/j.1471-4159.2011.07267.x
   Ghoshal K, 2001, PROG NUCLEIC ACID RE, V66, P357
   Glick D, 2012, MOL CELL BIOL, V32, P2570, DOI 10.1128/MCB.00167-12
   Guenette J, 1997, TOXICOL METHOD, V7, P77
   Heidbreder M, 2007, BIOCHEM BIOPH RES CO, V352, P437, DOI 10.1016/j.bbrc.2006.11.027
   Holz O, 1999, AM J RESP CRIT CARE, V159, P776, DOI 10.1164/ajrccm.159.3.9806098
   Horton JD, 2002, J CLIN INVEST, V109, P1125, DOI 10.1172/JCI200215593
   Hutcheson R, 2012, EXP DIABETES RES, DOI 10.1155/2012/271028
   Incerpi EK, 2015, INT J EXP PATHOL, V96, P133, DOI 10.1111/iep.12113
   Josephson MB, 2012, AM J PHYSIOL-LUNG C, V303, pL382, DOI 10.1152/ajplung.00125.2012
   Kainuma E, 2009, PSYCHONEUROENDOCRINO, V34, P1459, DOI 10.1016/j.psyneuen.2009.04.021
   Kim C, 2010, AM J PSYCHIAT, V167, P1100, DOI 10.1176/appi.ajp.2010.09050706
   Krämer U, 2010, ENVIRON HEALTH PERSP, V118, P1273, DOI 10.1289/ehp.0901689
   Kuo T, 2015, ADV EXP MED BIOL, V872, P99, DOI 10.1007/978-1-4939-2895-8_5
   Laskin DL, 2010, ANN NY ACAD SCI, V1203, P60, DOI 10.1111/j.1749-6632.2010.05607.x
   Li L, 2009, ENDOCRINOLOGY, V150, P24, DOI 10.1210/en.2008-0742
   Lim YH, 2012, ENVIRON HEALTH PERSP, V120, P1023, DOI 10.1289/ehp.1104100
   Liu CQ, 2013, TOXICOL PATHOL, V41, P361, DOI 10.1177/0192623312464531
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   Marinelli M, 1996, BRAIN RES, V724, P251, DOI 10.1016/0006-8993(96)00309-5
   Mehta AJ, 2015, ENVIRON HEALTH-GLOB, V14, DOI 10.1186/1476-069X-14-10
   Miller DB, 2015, TOXICOL APPL PHARM, V286, P65, DOI 10.1016/j.taap.2015.03.025
   Murray CJL, 2012, LANCET, V380, P2197, DOI 10.1016/S0140-6736(12)61729-2
   Newman NC, 2013, ENVIRON HEALTH PERSP, V121, P731, DOI 10.1289/ehp.1205555
   Park SK, 2010, ENVIRON HEALTH PERSP, V118, P1406, DOI 10.1289/ehp.0901778
   Power MC, 2011, ENVIRON HEALTH PERSP, V119, P682, DOI 10.1289/ehp.1002767
   R Core Team, 2015, R: a language and environment for statistical computing
   Raaschou-Nielsen O, 2013, DIABETOLOGIA, V56, P36, DOI 10.1007/s00125-012-2698-7
   Rajagopalan S, 2012, DIABETES, V61, P3037, DOI 10.2337/db12-0190
   Ranft U, 2009, ENVIRON RES, V109, P1004, DOI 10.1016/j.envres.2009.08.003
   Riediger ND, 2011, CAN MED ASSOC J, V183, pE1127, DOI 10.1503/cmaj.110070
   Rundle A, 2012, AM J EPIDEMIOL, V175, P1163, DOI 10.1093/aje/kwr455
   SampathKumar R, 1997, J STEROID BIOCHEM, V62, P195, DOI 10.1016/S0960-0760(97)00027-7
   Shpilberg Y, 2012, DIS MODEL MECH, V5, P671, DOI 10.1242/dmm.008912
   SILLENCE MN, 1987, J ENDOCRINOL, V113, P473, DOI 10.1677/joe.0.1130473
   Sominsky L, 2014, FRONT PSYCHOL, V5, DOI 10.3389/fpsyg.2014.00434
   STERNBERG EM, 1989, P NATL ACAD SCI USA, V86, P2374, DOI 10.1073/pnas.86.7.2374
   Sun QH, 2009, CIRCULATION, V119, P538, DOI 10.1161/CIRCULATIONAHA.108.799015
   Szyszkowicz M, 2010, ENVIRON HEALTH INSIG, V4, P79, DOI 10.4137/EHI.S5662
   Szyszkowicz M, 2009, INT J OCCUP MED ENV, V22, P355, DOI 10.2478/v10001-009-0031-6
   Thomson E, 2005, TOXICOL SCI, V88, P103, DOI 10.1093/toxsci/kfi272
   Thomson EM., 2014, ENDOCR DISRUPT, V1, pe27489
   Thomson EM, 2007, ENVIRON RES, V105, P224, DOI 10.1016/j.envres.2007.06.005
   Thomson EM, 2013, TOXICOL SCI, V135, P169, DOI 10.1093/toxsci/kft137
   Urch B, 2010, INHAL TOXICOL, V22, P210, DOI 10.3109/08958370903173666
   Vella RE, 2015, DIABETES, V64, P1011, DOI 10.2337/db13-1181
   VINCENT R, 1995, AM J PATHOL, V146, P1008
   Vinikoor-Imler LC, 2014, ENVIRON HEALTH PERSP, V122, P1166, DOI 10.1289/ehp.1307541
   Wagner JG, 2014, ENVIRON HEALTH PERSP, V122, P27, DOI [10.1289/ehp.1307085, 10.1289/ehp.122-A27]
   Watkinson WP, 2001, ENVIRON HEALTH PERSP, V109, P539, DOI 10.2307/3454666
   Weuve J, 2012, ARCH INTERN MED, V172, P219, DOI 10.1001/archinternmed.2011.683
   Yamamoto K, 2002, P NATL ACAD SCI USA, V99, P890, DOI 10.1073/pnas.022608799
   Zhang SQ, 2009, ANN ALLERG ASTHMA IM, V103, P525, DOI 10.1016/S1081-1206(10)60270-0
   Zhao QY, 1998, AM J PHYSIOL-LUNG C, V274, pL39, DOI 10.1152/ajplung.1998.274.1.L39
NR 75
TC 61
Z9 64
U1 2
U2 24
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD JUL
PY 2016
VL 152
IS 1
BP 17
EP 28
DI 10.1093/toxsci/kfw061
PG 12
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA DT2AA
UT WOS:000381282000003
PM 27037194
OA Bronze
DA 2025-06-11
ER

PT J
AU Tu, WJ
   Qiu, HC
   Liu, Q
   Li, XM
   Zhao, JZ
   Zeng, XW
AF Tu, Wen-Jun
   Qiu, Han-Cheng
   Liu, Qiang
   Li, Xuemei
   Zhao, Ji-Zong
   Zeng, Xianwei
TI Decreased level of irisin, a skeletal muscle cell-derived myokine, is
   associated with post-stroke depression in the ischemic stroke population
SO JOURNAL OF NEUROINFLAMMATION
LA English
DT Article
DE Irisin; Depression; Acute ischemic stroke; Chinese
ID IMPROVES ENDOTHELIAL FUNCTION; CIRCULATING IRISIN; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; ENERGY-METABOLISM; ADIPOSE-TISSUE; SERUM; EXERCISE;
   AMPK; ACTIVATION
AB Background: Depression is a frequent mood disorder in stroke patient. Our aim was to determine irisin levels in serum and investigate their associations with post-stroke depression (PSD) in a 6-month follow-up study in Chinese patients with first-ever acute ischemic stroke (AIS).
   Methods: The subjects were first-ever AIS patients who were hospitalized at three stroke centers during the period from January 2015 to December 2016. Neurological and neuropsychological evaluations were conducted at the 6-month follow-up. Serum irisin concentrations were measured by enzyme-linked immunosorbent assay (ELISA).
   Results: During the study period, 1205 patients were included in the analysis. There were 370 patients (30.7%) classified as depression. The depression distribution across the irisin quartiles ranged between 49.8% (first quartile) and 9.9% (fourth quartile). In the patients with depression, serum irisin levels were lower compared with those in patients without depression (P < 0.001). In a multivariate model using the first (Q1) quartile of irisin vs. Q2-4 together with the clinical variables, the marker displayed predictive information and increased risk of PSD by 75% (odds ratio [OR] for Q1, 1.75 [95% confidence interval [CI], 1.15-2.65]). In addition, a model containing known risk factors plus irisin compared with a model containing known risk factors without irisin showed a greater discriminatory ability; the area under the curve (AUC) increased from 0.77 to 0.81 (95% CI, 0.76-0.86).
   Conclusions: The data suggested that reduced serum levels of irisin were powerful biological markers of risk of developing PSD even after adjustment by variables. Further studies are necessary to confirm this association, which may open the way to the proposal of new therapeutic options.
C1 [Tu, Wen-Jun; Liu, Qiang] China Acad Med Sci, Inst Radiat Med, Tianjin, Peoples R China.
   [Tu, Wen-Jun; Liu, Qiang] Peking Union Med Coll, Tianjin, Peoples R China.
   [Tu, Wen-Jun; Qiu, Han-Cheng; Zhao, Ji-Zong] Capital Med Univ, Dept Neurosurg, Beijing Tiantan Hosp, Beijing, Peoples R China.
   [Tu, Wen-Jun; Li, Xuemei; Zeng, Xianwei] Weifang Med Univ, Inst Stroke, Ctr Translat Med, Weifang, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Institute of Radiation Medicine - CAMS; Chinese Academy of Medical
   Sciences - Peking Union Medical College; Peking Union Medical College;
   Capital Medical University; Shandong Second Medical University
RP Liu, Q (corresponding author), China Acad Med Sci, Inst Radiat Med, Tianjin, Peoples R China.; Liu, Q (corresponding author), Peking Union Med Coll, Tianjin, Peoples R China.; Zhao, JZ (corresponding author), Capital Med Univ, Dept Neurosurg, Beijing Tiantan Hosp, Beijing, Peoples R China.
EM liuqiang_cams@163.com; zhaojztj205@163.com
RI Tu, Wen-Jun/AAC-5696-2019; Liu, Qiang/AFK-6590-2022
OI Liu, Qiang/0000-0002-7668-6868
FU Shandong Province Science and Technology Development Plan Project
   [2015GGB14296]; Shandong Province Key Research and Development Projects
   [2016GSF201229]; National Natural Science Foundation of China
   [81671175]; CAMS Innovation Fund for Medical Science [2017-I2M-1-016]
FX This study was supported by grants from Shandong Province Science and
   Technology Development Plan Project (No. 2015GGB14296), Shandong
   Province Key Research and Development Projects (No. 2016GSF201229),
   National Natural Science Foundation of China (No. 81671175), and CAMS
   Innovation Fund for Medical Science (No. 2017-I2M-1-016).
CR Alis R, 2014, CLIN BIOCHEM, V47, P333, DOI 10.1016/j.clinbiochem.2014.08.017
   Anastasilakis AD, 2017, METABOLISM, V73, P1, DOI 10.1016/j.metabol.2017.05.002
   Balzer BWR, 2015, EUR J PEDIATR, V174, P289, DOI 10.1007/s00431-014-2475-3
   BONITA R, 1988, STROKE, V19, P1497, DOI 10.1161/01.STR.19.12.1497
   Boström P, 2012, NATURE, V481, P463, DOI 10.1038/nature10777
   Brondani LA, 2015, METABOLISM, V64, P952, DOI 10.1016/j.metabol.2015.05.005
   BROTT T, 1989, STROKE, V20, P864, DOI 10.1161/01.STR.20.7.864
   Carvalho AF, 2014, J PSYCHIATR RES, V59, P28, DOI 10.1016/j.jpsychires.2014.08.002
   Chen JQ, 2015, LIPIDS HEALTH DIS, V14, DOI 10.1186/1476-511X-14-2
   Cheng LS, 2018, MOL NEUROBIOL, V55, P2952, DOI 10.1007/s12035-017-0549-8
   Cheng SY, 2014, PSYCHONEUROENDOCRINO, V47, P126, DOI 10.1016/j.psyneuen.2014.05.006
   Choi YK, 2013, DIABETES RES CLIN PR, V100, P96, DOI 10.1016/j.diabres.2013.01.007
   Crujeiras AB, 2014, METABOLISM, V63, P520, DOI 10.1016/j.metabol.2013.12.007
   DATA D., 1997, STRUCTURED CLIN INTE
   Della FP, 2012, BEHAV BRAIN RES, V233, P526, DOI 10.1016/j.bbr.2012.05.039
   Efe TH, 2017, KOREAN CIRC J, V47, P44, DOI 10.4070/kcj.2016.0079
   Ferrer-Martínez A, 2002, DEV DYNAM, V224, P154, DOI 10.1002/dvdy.10099
   Fu JJ, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.116.003433
   Gao HQ, 2008, CLIN INVEST MED, V31, pE351
   Hadidi N, 2009, HEART LUNG, V38, P151, DOI 10.1016/j.hrtlng.2008.05.002
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Han F, 2015, AM J PHYSIOL-HEART C, V309, pH1501, DOI 10.1152/ajpheart.00443.2015
   Huh JY, 2014, J CLIN ENDOCR METAB, V99, pE2154, DOI 10.1210/jc.2014-1437
   Huh JY, 2012, METABOLISM, V61, P1725, DOI 10.1016/j.metabol.2012.09.002
   Hwang YC, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-015-0319-8
   Jang HB, 2017, METABOLISM, V73, P100, DOI 10.1016/j.metabol.2017.05.007
   Lee HJ, 2015, MOL ENDOCRINOL, V29, P873, DOI 10.1210/me.2014-1353
   Lehto SM, 2010, ACTA PSYCHIAT SCAND, V121, P209, DOI 10.1111/j.1600-0447.2009.01463.x
   Li DJ, 2017, METABOLISM, V68, P31, DOI 10.1016/j.metabol.2016.12.003
   Lu JY, 2015, ATHEROSCLEROSIS, V243, P438, DOI 10.1016/j.atherosclerosis.2015.10.020
   Moreno-Navarrete JM, 2013, J CLIN ENDOCR METAB, V98, pE769, DOI 10.1210/jc.2012-2749
   Mathers CD, 2009, BRIT MED BULL, V92, P7, DOI 10.1093/bmb/ldp028
   Miller AH, 2009, BIOL PSYCHIAT, V65, P732, DOI 10.1016/j.biopsych.2008.11.029
   Nowrouzi-Kia B, 2018, SAF HEALTH WORK-KR, V9, P144
   Park KH, 2013, J CLIN ENDOCR METAB, V98, P4899, DOI 10.1210/jc.2013-2373
   Pencina MJ, 2008, STAT MED, V27, P157, DOI 10.1002/sim.2929
   Preiss K, 2013, OBES REV, V14, P906, DOI 10.1111/obr.12052
   Raschke S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0073680
   Robson MJ, 2017, ACS CHEM NEUROSCI, V8, P932, DOI 10.1021/acschemneuro.6b00412
   Roca-Rivada A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0060563
   Rodríguez-Carmona A, 2016, NEFROLOGIA, V36, P496, DOI 10.1016/j.nefro.2016.05.019
   Sanchis-Gomar F, 2013, ANN NUTR METAB, V63, P60, DOI 10.1159/000354090
   Schuch FB, 2016, J PSYCHIATR RES, V77, P42, DOI 10.1016/j.jpsychires.2016.02.023
   Shan TZ, 2013, FASEB J, V27, P1981, DOI 10.1096/fj.12-225755
   Sims JR, 2009, NEUROLOGY, V72, P2104, DOI 10.1212/WNL.0b013e3181aa5329
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   van Sloten TT, 2014, PSYCHOL MED, V44, P1403, DOI 10.1017/S0033291713002043
   Vogelzangs N, 2007, PSYCHONEUROENDOCRINO, V32, P151, DOI 10.1016/j.psyneuen.2006.11.009
   Wang SS, 2016, BIOCHEM BIOPH RES CO, V474, P22, DOI 10.1016/j.bbrc.2016.04.047
   Wrann Christiane D, 2015, Brain Plast, V1, P55, DOI 10.3233/BPL-150019
   Wu HS, 2019, CYTOKINE, V122, DOI 10.1016/j.cyto.2018.02.017
   Xin C, 2016, INT J OBESITY, V40, P443, DOI 10.1038/ijo.2015.199
   Zhang WZ, 2015, NEUROSCI LETT, V595, P7, DOI 10.1016/j.neulet.2015.03.069
   Zhu D, 2015, J MOL CELL CARDIOL, V87, P138, DOI 10.1016/j.yjmcc.2015.07.015
NR 54
TC 59
Z9 59
U1 0
U2 24
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1742-2094
J9 J NEUROINFLAMM
JI J. Neuroinflamm.
PD MAY 2
PY 2018
VL 15
AR 133
DI 10.1186/s12974-018-1177-6
PG 10
WC Immunology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology
GA GE9OB
UT WOS:000431557900004
PM 29720216
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bai, YM
   Chiou, WF
   Su, TP
   Li, CT
   Chen, MH
AF Bai, Ya-Mei
   Chiou, Wen-Fei
   Su, Tung-Ping
   Li, Cheng-Ta
   Chen, Mu-Hong
TI Pro-inflammatory cytokine associated with somatic and pain symptoms in
   depression
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Pro-inflammatory cytokines; Somatic and pain symptoms; Depression
ID C-REACTIVE PROTEIN; ALPHA TNF-ALPHA; QUALITY-OF-LIFE; PLATELET
   ACTIVATION; PHYSICAL SYMPTOMS; P-SELECTIN; SOLUBLE
   INTERLEUKIN-2-RECEPTOR; PSYCHIATRIC OUTPATIENTS; METABOLIC SYNDROME;
   CHINESE PATIENTS
AB Background: More than two-thirds of depressed patients complain of somatic and pain symptoms, which are frequently regarded as a psychological reaction. Although there is a growing body of evidence showing that depression is related to immune abnormalities, few studies have investigated the association between inflammatory cytokines and somatic/pain symptoms.
   Method: Patients with depressive disorder but without any medical disorders, and age/gender/body mass index (BMI)-matched healthy subjects were enrolled. All the subjects completed the self-rating scales of the Beck Depression Inventory-II and the Depression and Somatic Symptoms Scale, which was comprised of depressive, somatic, and pain subscales. Pro-inflammatory cytokines, including C-reactive protein (CRP), interleukin-2 receptor (sIL-2R), soluble interleukin 6 receptor (sIL-6R), soluble TNF-receptors (sTNF-R), soluble P-selectin (sP-selectin), monocyte chemotactic protein-1 (MCP-1), and adiponectin, were assessed by enzyme linked immunosorbent assays.
   Results: In all, 109 patients with depressive disorder and 126 normal controls were enrolled. The patients with depressive disorder had significantly more severe depression, somatic and pain symptoms (all p <0.001), and higher levels of sIL-2R (p <0.0001), sTNF-R (p <0,001), and sP-selectin (p=0.005) than the normal control group. Using multivariate regression analysis with controlling of age, gender, BMI, and other pro inflammatory cytokines, sIL-2R was the most significant predictor for depressive symptoms (p <0.0001); with further controlling of severity of depressive symptom, sP-selectin was the only predictor for somatic (p=0.002) and pain (p=0.059) symptoms.
   Conclusion: The elevated sP-selectin associated with somatic symptoms in depression, may indicate early micro vascular changes occur subtly, and provide neurobiological evidence for somatic and pain symptom in depression. (C) 2013 Elsevier B.V. All rights reserved
C1 [Bai, Ya-Mei; Su, Tung-Ping; Li, Cheng-Ta; Chen, Mu-Hong] Taipei Vet Gen Hosp, Dept Psychiat, Taipei 11217, Taiwan.
   [Bai, Ya-Mei; Su, Tung-Ping; Li, Cheng-Ta] Natl Yang Ming Univ, Coll Med, Dept Psychiat, Taipei 112, Taiwan.
   [Chiou, Wen-Fei] Natl Res Inst Chinese Med, Taipei, Taiwan.
   [Chiou, Wen-Fei] Natl Taitung Univ, Inst Life Sci, Taitung, Taiwan.
   [Chiou, Wen-Fei] Natl Yang Ming Univ, Sch Med, Inst Tradit Med, Taipei 112, Taiwan.
C3 Taipei Veterans General Hospital; National Yang Ming Chiao Tung
   University; National Research Institute of Chinese Medicine; National
   Yang Ming Chiao Tung University
RP Bai, YM (corresponding author), Taipei Vet Gen Hosp, Dept Psychiat, 201 Shih Pai Rd,Sect 2, Taipei 11217, Taiwan.
EM ymbi@mail2000.com.tw
RI Li, Cheng-Ta/AAI-5759-2021; Chen, MuHong/ACJ-6131-2022
OI Li, Cheng-Ta/0000-0002-0670-1153
FU Taiwan National Science Council [NSC 99-2628-B-075-004-MY3, NSC
   102-2628-B-075-005-MY2]; Taipei Veterans General Hospital [V101C-063,
   V102C-057]
FX The study was supported by grants from Taiwan National Science Council
   (NSC 99-2628-B-075-004-MY3; NSC 102-2628-B-075-005-MY2), and Taipei
   Veterans General Hospital (V101C-063; V102C-057).
CR Al-Shukaili A, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/976810
   [Anonymous], MOL PSYCHIAT
   [Anonymous], J OBES
   Aschbacher K, 2008, BRAIN BEHAV IMMUN, V22, P493, DOI 10.1016/j.bbi.2007.10.002
   Aschbacher K, 2009, J AFFECT DISORDERS, V116, P80, DOI 10.1016/j.jad.2008.11.008
   Bai YM, 2007, J CLIN PSYCHIAT, V68, P1834, DOI 10.4088/JCP.v68n1202
   Bai YM, 2009, SCHIZOPHR RES, V111, P1, DOI 10.1016/j.schres.2009.03.014
   Belalcazar LM, 2013, OBESITY, V21, P944, DOI 10.1002/oby.20431
   Capuron L, 2001, PSYCHONEUROENDOCRINO, V26, P797, DOI 10.1016/S0306-4530(01)00030-0
   Capuron L, 2011, PHARMACOL THERAPEUT, V130, P226, DOI 10.1016/j.pharmthera.2011.01.014
   Demyttenaere K, 2006, J AFFECT DISORDERS, V92, P185, DOI 10.1016/j.jad.2006.01.007
   Denninger JW, 2006, PSYCHOSOMATICS, V47, P348, DOI 10.1176/appi.psy.47.4.348
   Do DP, 2010, PSYCHOSOM MED, V72, P613, DOI 10.1097/PSY.0b013e3181e2cca5
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Duivis HE, 2013, PSYCHONEUROENDOCRINO, V38, P1573, DOI 10.1016/j.psyneuen.2013.01.002
   El-Mesallamy HO, 2011, INDIAN PEDIATR, V48, P815
   Eller T, 2009, MED LITH, V45, P971, DOI 10.3390/medicina45120124
   Euteneuer F, 2012, BRAIN BEHAV IMMUN, V26, P1244, DOI 10.1016/j.bbi.2012.06.007
   Euteneuer F, 2011, J AFFECT DISORDERS, V131, P143, DOI 10.1016/j.jad.2010.11.017
   Farabaugh A, 2005, INT CLIN PSYCHOPHARM, V20, P87, DOI 10.1097/00004850-200503000-00004
   Fava M, 2004, J CLIN PSYCHIAT, V65, P521
   Goyal R, 2012, N AM J MED SCI, V4, P180, DOI 10.4103/1947-2714.94944
   Greco T, 2004, J GEN INTERN MED, V19, P813, DOI 10.1111/j.1525-1497.2004.30531.x
   Harrison NA, 2009, BIOL PSYCHIAT, V66, P407, DOI 10.1016/j.biopsych.2009.03.015
   Hepgul N., 2012, CURR TOP BEHAV NEURO
   Hood K.K., 2012, DIABETES CARE
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Hsu SC, 2009, COMPR PSYCHIAT, V50, P151, DOI 10.1016/j.comppsych.2008.07.002
   Hung CI, 2008, J PSYCHOSOM RES, V65, P135, DOI 10.1016/j.jpsychores.2008.04.011
   Hung CI, 2008, J PSYCHOSOM RES, V64, P231, DOI 10.1016/j.jpsychores.2007.08.012
   Hung CI, 2006, PSYCHIAT CLIN NEUROS, V60, P700, DOI 10.1111/j.1440-1819.2006.01585.x
   Hung CI, 2006, PSYCHOL REP, V99, P379, DOI 10.2466/PR0.99.2.379-389
   Hung CI, 2010, J AFFECT DISORDERS, V125, P134, DOI 10.1016/j.jad.2009.12.010
   Hung CI, 2009, DEPRESS ANXIETY, V26, P583, DOI 10.1002/da.20464
   Hung CI, 2006, CEPHALALGIA, V26, P26, DOI 10.1111/j.1468-2982.2005.00985.x
   Jeong HG, 2012, PSYCHONEUROENDOCRINO, V37, P948, DOI 10.1016/j.psyneuen.2011.11.002
   Jones K.A., 2012, MOL CELL NEUROSCI
   Karp JF, 2005, J CLIN PSYCHIAT, V66, P591, DOI 10.4088/JCP.v66n0508
   Karrenbauer BD, 2011, J NEUROIMMUNOL, V237, P23, DOI 10.1016/j.jneuroim.2011.05.011
   Kim G, 2011, CULT DIVERS ETHN MIN, V17, P381, DOI 10.1037/a0025434
   Krishnadas R, 2012, J NEUROL NEUROSUR PS, V83, P495, DOI 10.1136/jnnp-2011-301779
   Kuba VM, 2013, BMC PEDIATR, V13, DOI 10.1186/1471-2431-13-91
   Lederbogen F, 2004, PSYCHIAT RES, V127, P55, DOI 10.1016/j.psychres.2004.03.008
   Li ZZ, 2013, PSYCHONEUROENDOCRINO, V38, P107, DOI 10.1016/j.psyneuen.2012.05.005
   Liu J, 2012, P NATL ACAD SCI USA, V109, P12248, DOI 10.1073/pnas.1202835109
   Liu Y, 2012, J AFFECT DISORDERS, V139, P230, DOI 10.1016/j.jad.2011.08.003
   McIntyre RS, 2006, J PSYCHOSOM RES, V60, P279, DOI 10.1016/j.jpsychores.2005.09.010
   McNamara RK, 2012, EXPERT REV NEUROTHER, V12, P1143, DOI [10.1586/ERN.12.98, 10.1586/ern.12.98]
   Mendoza-Sotelo J, 2010, PSYCHIAT RES, V176, P179, DOI 10.1016/j.psychres.2009.07.021
   Moorman AJ, 2007, J CARD FAIL, V13, P738, DOI 10.1016/j.cardfail.2007.06.301
   Morel-Kopp MC, 2009, J THROMB HAEMOST, V7, P573, DOI 10.1111/j.1538-7836.2009.03278.x
   Musselman DL, 1996, AM J PSYCHIAT, V153, P1313
   Musselman DL, 2001, AM J PSYCHIAT, V158, P1252, DOI 10.1176/appi.ajp.158.8.1252
   Nakao M, 2006, J AFFECT DISORDERS, V90, P29, DOI 10.1016/j.jad.2005.09.010
   Nemet D, 2013, HORM RES PAEDIAT, V79, P325, DOI 10.1159/000348732
   Panee J, 2012, CYTOKINE, V60, P1, DOI 10.1016/j.cyto.2012.06.018
   Papakostas GI, 2004, J CLIN PSYCHIAT, V65, P543
   Peters M.J., 2012, CYTOKINE
   Piletz JE, 2009, WORLD J BIOL PSYCHIA, V10, P313, DOI 10.3109/15622970802573246
   Schins A, 2005, J PSYCHIATR RES, V39, P137, DOI 10.1016/j.jpsychires.2004.05.009
   Shenoy AR, 2013, J NEUROIMMUNOL, V262, P46, DOI 10.1016/j.jneuroim.2013.06.006
   Simon GE, 1999, NEW ENGL J MED, V341, P1329, DOI 10.1056/NEJM199910283411801
   Sperner-Unterweger B., 2012, PROG NEUROPSYCHOPHAR
   Su KP, 2009, NEUROSIGNALS, V17, P144, DOI 10.1159/000198167
   Suarez EC, 2003, PSYCHOSOM MED, V65, P362, DOI 10.1097/01.PSY.0000035719.79068.2B
   Tomer A, 2004, J BIOL REG HOMEOS AG, V18, P172
   Trujillo ME, 2005, J INTERN MED, V257, P167, DOI 10.1111/j.1365-2796.2004.01426.x
   Utsal L, 2012, HORM RES PAEDIAT, V78, P31, DOI 10.1159/000339831
   Valle M, 2005, DIABETES METAB, V31, P55, DOI 10.1016/S1262-3636(07)70167-2
   Vieta E, 2008, J AFFECT DISORDERS, V107, P169, DOI 10.1016/j.jad.2007.08.007
   Waza K, 1999, FAM PRACT, V16, P528, DOI 10.1093/fampra/16.5.528
   Williams JBW, 2008, BRIT J PSYCHIAT, V192, P52, DOI 10.1192/bjp.bp.106.032532
   Wirtz PH, 2009, BIOL PSYCHIAT, V65, P801, DOI 10.1016/j.biopsych.2008.11.013
NR 73
TC 65
Z9 70
U1 0
U2 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD FEB
PY 2014
VL 155
BP 28
EP 34
DI 10.1016/j.jad.2013.10.019
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 287XB
UT WOS:000329574500004
PM 24176538
DA 2025-06-11
ER

PT J
AU Keller, J
   Gomez, R
   Williams, G
   Lembke, A
   Lazzeroni, L
   Urphy, GM
   Schatzberg, AF
AF Keller, J.
   Gomez, R.
   Williams, G.
   Lembke, A.
   Lazzeroni, L.
   urphy, G. M., Jr.
   Schatzberg, A. F.
TI HPA axis in major depression: cortisol, clinical symptomatology and
   genetic variation predict cognition
SO MOLECULAR PSYCHIATRY
LA English
DT Article
ID MESSENGER-RNA EXPRESSION; MINERALOCORTICOID RECEPTOR;
   GLUCOCORTICOID-RECEPTOR; NEUROCOGNITIVE FUNCTION; MEMORY IMPAIRMENTS;
   METABOLIC SYNDROME; WORKING-MEMORY; ASSOCIATION; CORTICOSTEROIDS;
   POLYMORPHISMS
AB The hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the pathophysiology of a variety of mood and cognitive disorders. Neuroendocrine studies have demonstrated HPA axis overactivity in major depression, a relationship of HPA axis activity to cognitive performance and a potential role of HPA axis genetic variation in cognition. The present study investigated the simultaneous roles HPA axis activity, clinical symptomatology and HPA genetic variation play in cognitive performance. Patients with major depression with psychotic major depression (PMD) and with nonpsychotic major depression (NPMD) and healthy controls (HC) were studied. All participants underwent a diagnostic interview and psychiatric ratings, a comprehensive neuropsychological battery, overnight hourly blood sampling for cortisol and genetic assessment. Cognitive performance differed as a function of depression subtype. Across all subjects, cognitive performance was negatively correlated with higher cortisol, and PMD patients had higher cortisol than did NPMDs and HCs. Cortisol, clinical symptoms and variation in genes, NR3C1 (glucocorticoid receptor; GR) and NR3C2 (mineralocorticoid receptor; MR) that encode for GRs and MRs, predicted cognitive performance. Beyond the effects of cortisol, demographics and clinical symptoms, NR3C1 variation predicted attention and working memory, whereas NR3C2 polymorphisms predicted memory performance. These findings parallel the distribution of GR and MR in primate brain and their putative roles in specific cognitive tasks. HPA axis genetic variation and activity were important predictors of cognition across the entire sample of depressed subjects and HR. GR and MR genetic variation predicted unique cognitive functions, beyond the influence of cortisol and clinical symptoms. GR genetic variation was implicated in attention and working memory, whereas MR was implicated in verbal memory.
C1 [Keller, J.; Gomez, R.; Lembke, A.; Lazzeroni, L.; urphy, G. M., Jr.; Schatzberg, A. F.] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA USA.
   [Gomez, R.] Palo Alto Univ, Boston, MA USA.
   [Williams, G.] Brigham & Womens Hosp, Harvard Med Sch, Boston, MA USA.
C3 Stanford University; Harvard University; Harvard Medical School; Harvard
   University Medical Affiliates; Brigham & Women's Hospital
RP Keller, J (corresponding author), Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, 401 Quarry Rd,Rm 2143, Stanford, CA 94305 USA.
EM jkeller@stanford.edu
RI Lazzeroni, Laura/F-2903-2010
OI Lazzeroni, Laura/0000-0002-1846-6920
FU Pritzker Foundation; NIH [MH50604, MH19938]; NIH/NCRR CTSA award [UL1
   RR025744]
FX Aspects of this study were supported by grants from the Pritzker
   Foundation, NIH MH50604 to Alan Schatzberg, NIH MH19938 to Alan
   Schatzberg, and NIH/NCRR CTSA award number UL1 RR025744. The clinical
   trial registration number was NCT00576095.
CR Belanoff JK, 2001, AM J PSYCHIAT, V158, P1612, DOI 10.1176/appi.ajp.158.10.1612
   Bortoluzzi A, 2014, J PSYCHIAT RES
   Bruehl H, 2007, J CLIN ENDOCR METAB, V92, P2439, DOI 10.1210/jc.2006-2540
   Buckley TM, 2005, AM J GERIAT PSYCHIAT, V13, P344, DOI 10.1176/appi.ajgp.13.5.344
   Cellini E, 2010, PSYCHIAT GENET, V20, P282, DOI 10.1097/YPG.0b013e32833a2142
   de Kloet ER, 2016, J NEUROENDOCRINOL, V28, DOI 10.1111/jne.12379
   de Kloet ER, 1999, TRENDS NEUROSCI, V22, P422, DOI 10.1016/S0166-2236(99)01438-1
   DEKLOET ER, 1987, PSYCHONEUROENDOCRINO, V12, P83, DOI 10.1016/0306-4530(87)90040-0
   Deuschle M, 1997, LIFE SCI, V61, P2239, DOI 10.1016/S0024-3205(97)00926-0
   El-Hage W, 2013, MOL PSYCHIATR, V18, P174, DOI 10.1038/mp.2011.145
   Fortier ME, 2013, NEUROMOL MED, V15, P122, DOI 10.1007/s12017-012-8202-1
   Gil-Bea FJ, 2010, J ALZHEIMERS DIS, V22, P829, DOI 10.3233/JAD-2010-100663
   Gold SM, 2007, DIABETOLOGIA, V50, P711, DOI 10.1007/s00125-007-0602-7
   Gomez RG, 2006, BIOL PSYCHIAT, V60, P472, DOI 10.1016/j.biopsych.2005.11.010
   Gomez-Sanchez EP, 2012, MOL CELL ENDOCRINOL, V350, P289, DOI 10.1016/j.mce.2011.05.005
   Gragnoli C, 2014, APPL CLIN GENET, V7, P43, DOI 10.2147/TACG.S39993
   Grossmann C, 2004, EUR J ENDOCRINOL, V151, P397, DOI 10.1530/eje.0.1510397
   Hamstra DA, 2015, NEUROSCIENCE, V286, P412, DOI 10.1016/j.neuroscience.2014.12.004
   Hardeveld F, 2015, PSYCHONEUROENDOCRINO, V55, P154, DOI 10.1016/j.psyneuen.2015.02.013
   Holsboer F, 2000, NEUROPSYCHOPHARMACOL, V23, P477, DOI 10.1016/S0893-133X(00)00159-7
   Joels M, 2008, TRENDS NEUROSCI, V31, P1, DOI 10.1016/j.tins.2007.10.005
   Keller J, 2006, BIOL PSYCHIAT, V60, P275, DOI 10.1016/j.biopsych.2005.10.014
   Kumsta R, 2007, BIOL PSYCHIAT, V62, P863, DOI 10.1016/j.biopsych.2007.04.013
   Landro NI, 2001, NEUROPSY NEUROPSY BE, V14, P233
   Lasic D, 2014, PSYCHIAT DANUB, V26, P214
   Lembke A, 2013, PSYCHONEUROENDOCRINO, V38, P115, DOI 10.1016/j.psyneuen.2012.05.006
   Leszczynska-Rodziewicz A, 2013, PSYCHIAT RES, V207, P140, DOI 10.1016/j.psychres.2012.09.025
   Liu NJ, 2008, ADV GENET, V60, P335, DOI 10.1016/S0065-2660(07)00414-2
   Lucassen Paul J., 2006, CNS & Neurological Disorders-Drug Targets, V5, P531, DOI 10.2174/187152706778559273
   Lupien SJ, 1999, BEHAV NEUROSCI, V113, P420, DOI 10.1037/0735-7044.113.3.420
   McClintock SA, 2010, NEUROPSYCHOLOGY, V24, P9, DOI 10.1037/a0017336
   McDermott LM, 2009, J AFFECT DISORDERS, V119, P1, DOI 10.1016/j.jad.2009.04.022
   Medina A, 2013, J PSYCHIATR RES, V47, P307, DOI 10.1016/j.jpsychires.2012.11.002
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   MURPHY BEP, 1991, J STEROID BIOCHEM, V38, P537
   Murphy FC, 2003, PSYCHOL MED, V33, P455, DOI 10.1017/S0033291702007018
   Naismith SL, 2007, BMC PSYCHIATRY, V7, DOI 10.1186/1471-244X-7-32
   Nelson JC, 1997, AM J PSYCHIAT, V154, P1497, DOI 10.1176/ajp.154.11.1497
   Otte C, 2015, NEUROPSYCHOPHARMACOL, V40, P386, DOI 10.1038/npp.2014.181
   Otte C, 2010, J PSYCHIATR RES, V44, P339, DOI 10.1016/j.jpsychires.2009.10.006
   Pan A, 2010, ARCH INTERN MED, V170, P1884, DOI 10.1001/archinternmed.2010.356
   Patel PD, 2000, J PSYCHIATR RES, V34, P383, DOI 10.1016/S0022-3956(00)00035-2
   PFOHL B, 1985, ARCH GEN PSYCHIAT, V42, P897
   Reppermund S, 2009, PSYCHOL MED, V39, P603, DOI 10.1017/S003329170800411X
   Rimmele U, 2013, NEUROPSYCHOPHARMACOL, V38, P884, DOI 10.1038/npp.2012.254
   Rock PL, 2014, PSYCHOL MED, V44, P2029, DOI 10.1017/S0033291713002535
   Rovaris DL, 2013, J NEURAL TRANSM, V120, P1499, DOI 10.1007/s00702-013-1012-2
   Schatzberg AF, 2014, MOL PSYCHIATR, V19, P1151, DOI 10.1038/mp.2014.57
   SECKL JR, 1991, BRAIN RES, V561, P332, DOI 10.1016/0006-8993(91)91612-5
   Sun JY, 2014, J ALZHEIMERS DIS, V41, P1039, DOI 10.3233/JAD-140054
   Szczepankiewicz A, 2011, J AFFECT DISORDERS, V134, P138, DOI 10.1016/j.jad.2011.06.020
   van Rossum EFC, 2011, ENDOCR DEV, V20, P127, DOI 10.1159/000321234
   Vinson GP, 2007, MED HYPOTHESES, V68, P1200, DOI 10.1016/j.mehy.2006.09.065
   Vogel S, 2014, PSYCHONEUROENDOCRINO, V40, P181, DOI 10.1016/j.psyneuen.2013.11.010
   Wang CE, 2006, J AFFECT DISORDERS, V92, P283, DOI 10.1016/j.jad.2006.02.008
   Yan YX, 2014, ENDOCRINE, V47, P740, DOI 10.1007/s12020-014-0324-9
   Yehuda R, 1996, BIOL PSYCHIAT, V40, P79, DOI 10.1016/0006-3223(95)00451-3
   Young AH, 2004, NEUROPSYCHOPHARMACOL, V29, P1538, DOI 10.1038/sj.npp.1300471
   Young EA, 2003, ARCH GEN PSYCHIAT, V60, P24, DOI 10.1001/archpsyc.60.1.24
NR 59
TC 586
Z9 656
U1 17
U2 227
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD APR
PY 2017
VL 22
IS 4
BP 527
EP 536
DI 10.1038/mp.2016.120
PG 10
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA EP0TP
UT WOS:000397099900006
PM 27528460
OA Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU De Stefano, A
   Mannucci, L
   Tamburi, F
   Cardillo, C
   Schinzari, F
   Rovellas, V
   Nisticò, S
   Bennardo, L
   Di Daniele, N
   Tesauro, M
AF De Stefano, Alessandro
   Mannucci, Liliana
   Tamburi, Federica
   Cardillo, Carmine
   Schinzari, Francesca
   Rovellas, Valentina
   Nistico, Steven
   Bennardo, Luigi
   Di Daniele, Nicola
   Tesauro, Manfredi
TI Lp-PLA2, a new biomarker of vascular disorders in metabolic
   diseases
SO INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
LA English
DT Article
DE biomarker; Lp-PLA(2); vascular inflammation
ID IMPROVES
AB Metabolic diseases are chronic disorders correlated to a greater risk of cardiovascular event and death. Recently, many data have sustained the biological link between microvascular dysfunction, oxidative stress, vascular inflammation, and metabolic diseases. The determination of new and specific blood biomarkers of vascular inflammation associated with obesity-related metabolic syndrome (MetS) and diabetes such as lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) could be useful to identify subject with high risk of cardiovascular events. Lp-PLA(2) participates by a crucial role in microvascular dysfunction and oxidative stress showing positive association with metabolic disorders. In this review, we will argue the evolving role of Lp-PLA(2) in predicting cardiovascular events in metabolic disease patients.
C1 [De Stefano, Alessandro; Rovellas, Valentina; Di Daniele, Nicola; Tesauro, Manfredi] Univ Roma Tor Vergata, Dept Syst Med, Rome, Italy.
   [Mannucci, Liliana] Univ Roma Tor Vergata, Dept Biomed & Prevent, Rome, Italy.
   [Tamburi, Federica; Cardillo, Carmine; Schinzari, Francesca] Univ Cattolica Sacro Cuore, Dept Internal Med, Rome, Italy.
   [Nistico, Steven; Bennardo, Luigi] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Viale Europa, I-88100 Catanzaro, Italy.
C3 University of Rome Tor Vergata; University of Rome Tor Vergata; Catholic
   University of the Sacred Heart; IRCCS Policlinico Gemelli; Magna Graecia
   University of Catanzaro
RP Nisticò, S (corresponding author), Magna Graecia Univ Catanzaro, Dept Hlth Sci, Viale Europa, I-88100 Catanzaro, Italy.
EM steven.nistico@gmail.com
RI schinzari, francesca/AAB-9982-2019; Bennardo, Luigi/ABA-6474-2020
OI Mannucci, Liliana/0000-0003-2729-9957; Cardillo,
   Carmine/0000-0001-5182-3005; Nistico, Steven/0000-0002-3828-0883
CR Acevedo M, 2015, INT J ENDOCRINOL, V2015, DOI 10.1155/2015/934681
   De Stefano A, 2017, BIOCHEM MEDICA, V27, P492, DOI 10.11613/BM.2017.030701
   Femlak M, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0594-3
   Grandl G, 2018, SEMIN IMMUNOPATHOL, V40, P215, DOI 10.1007/s00281-017-0666-5
   Hatoum IJ, 2010, DIABETES, V59, P1239, DOI 10.2337/db09-0730
   Jackisch L, 2018, DIABETOLOGIA, V61, P1155, DOI 10.1007/s00125-018-4558-6
   Julve J, 2014, ATHEROSCLEROSIS, V234, P200, DOI 10.1016/j.atherosclerosis.2014.02.034
   Rymer JA, 2017, J AM COLL CARDIOL, V4, P484
   Schinzari F, 2017, J CARDIOVASC PHARM, V69, P360, DOI 10.1097/FJC.0000000000000469
   Siddiqui MK, 2018, DIABETOLOGIA, V61, P1344, DOI 10.1007/s00125-018-4601-7
   Stafforini Diana M, 2015, Enzymes, V38, P71, DOI 10.1016/bs.enz.2015.09.004
   Tesauro M, 2008, DIABETES CARE, V31, P1439, DOI 10.2337/dc08-0219
NR 12
TC 35
Z9 36
U1 2
U2 8
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0394-6320
EI 2058-7384
J9 INT J IMMUNOPATH PH
JI Int. J. Immunopathol. Pharmacol.
PD FEB 1
PY 2019
VL 33
AR 2058738419827154
DI 10.1177/2058738419827154
PG 4
WC Immunology; Pathology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pathology; Pharmacology & Pharmacy
GA HM6FT
UT WOS:000459570200001
PM 30706739
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Burke, A
   Lucey, MR
AF Burke, A
   Lucey, MR
TI Non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and
   orthotopic liver transplantation
SO AMERICAN JOURNAL OF TRANSPLANTATION
LA English
DT Review
DE fatty liver disease; insulin resistance; liver transplantation; obesity;
   oxidative stress
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; HEPATIC STEATOSIS;
   NATURAL-HISTORY; CRYPTOGENIC CIRRHOSIS; UNCOUPLING PROTEIN-2; PRIMARY
   NONFUNCTION; LIPID-PEROXIDATION; RISK-FACTORS; DONOR LIVER
AB Obesity, non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are becoming increasingly common medical problems in the developed world, often in the setting of the metabolic or insulin resistance syndrome (IRS). It is predicted that by the year 2025 > 25 million Americans may have NASH-related liver disease. NASH and NAFLD also affect the donor population. The use of steatotic donor livers for liver transplantation (LT) is associated with an increased risk of primary nonfunction (PNF) in the allograft. There is particular reluctance to use steatotic livers for living donor LT. There is indirect evidence to suggest that patients undergoing LT for cirrhosis resulting from NASH may have poorer outcome, despite careful selection of LT candidates. Indeed it is likely that many potential LT candidates with NASH are excluded from LT due to co-morbid conditions related to IRS. The post-LT patient is at risk of several components of IRS, such as diabetes mellitus, hypertension, hyperlipidaemia and obesity and there is increasing recognition of de novo and recurrent NAFLD and NASH after LT. Thus NAFLD and NASH affect all aspects of LT including donors, patients in evaluation and the LT recipient.
C1 Univ Wisconsin, Sch Med, Sect Gastroenterol & Hepatol, Madison, WI 53792 USA.
   Univ Penn, Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA.
C3 University of Wisconsin System; University of Wisconsin Madison;
   University of Pennsylvania
RP Univ Wisconsin, Sch Med, Sect Gastroenterol & Hepatol, Madison, WI 53792 USA.
EM mrl@medicine.wisc.edu
RI Lucey, Michael/AAR-4571-2020
CR Adams LA, 2003, HEPATOLOGY, V38, p206A
   Angulo P, 1999, HEPATOLOGY, V30, P1356, DOI 10.1002/hep.510300604
   [Anonymous], 2002, Gastroenterology, V123, P1702
   BACON BR, 1994, GASTROENTEROLOGY, V107, P1103, DOI 10.1016/0016-5085(94)90235-6
   BOGARDUS C, 2003, AM J PHYSIOL, V248, pE286
   BORONA E, 1984, HORM METAB RES, V16, P111
   Brandhagen D, 2003, LIVER TRANSPLANT, V9, pS16, DOI 10.1053/jlts.2003.50222
   Burke A, 2002, TRANSPLANTATION, V74, P217, DOI 10.1097/00007890-200207270-00012
   BURKE A, 2003, LIVER TRANSPLANT, P98
   Caldwell SH, 1999, HEPATOLOGY, V29, P664, DOI 10.1002/hep.510290347
   Cauble MS, 2001, TRANSPLANTATION, V71, P892, DOI 10.1097/00007890-200104150-00012
   Charlton M, 2001, LIVER TRANSPLANT, V7, P608, DOI 10.1053/jlts.2001.25453
   Chavin KD, 1999, J BIOL CHEM, V274, P5692, DOI 10.1074/jbc.274.9.5692
   Chitturi S, 2002, HEPATOLOGY, V35, P373, DOI 10.1053/jhep.2002.30692
   CISNEROS C, 1991, TRANSPLANT P, V23, P1976
   Contos MJ, 2001, LIVER TRANSPLANT, V7, P363, DOI 10.1053/jlts.2001.23011
   Cortez-Pinto H, 1999, GASTROENTEROLOGY, V116, P1184, DOI 10.1016/S0016-5085(99)70022-3
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   Dixon JB, 2001, GASTROENTEROLOGY, V121, P91, DOI 10.1053/gast.2001.25540
   *EUR LIV TRANSPL N, 2002, PRIM IND LIV TRANSPL
   Evans CDJ, 2002, J CLIN PATHOL, V55, P689, DOI 10.1136/jcp.55.9.689
   Fassio E, 2003, HEPATOLOGY, V38, p231A
   FernandezCheca JC, 1997, AM J PHYSIOL-GASTR L, V273, pG7, DOI 10.1152/ajpgi.1997.273.1.G7
   Fishbein TM, 1997, TRANSPLANTATION, V64, P248, DOI 10.1097/00007890-199707270-00012
   Flegal KM, 2002, JAMA-J AM MED ASSOC, V288, P1723, DOI 10.1001/jama.288.14.1723
   Fukumori T, 1999, TRANSPLANTATION, V67, P195, DOI 10.1097/00007890-199901270-00002
   García-Monzón C, 2000, J HEPATOL, V33, P716, DOI 10.1016/S0168-8278(00)80301-3
   Gopaul NK, 2001, DIABETOLOGIA, V44, P706, DOI 10.1007/s001250051679
   Greenlee RT, 2001, CA-CANCER J CLIN, V51, P15, DOI 10.3322/canjclin.51.1.15
   HILDEN M, 1977, SCAND J GASTROENTERO, V12, P593, DOI 10.3109/00365527709181339
   Hotamisligil GS, 1999, J INTERN MED, V245, P621, DOI 10.1046/j.1365-2796.1999.00490.x
   Hotamisligil GS, 1996, SCIENCE, V271, P665, DOI 10.1126/science.271.5249.665
   HUI AM, 1994, HEPATOLOGY, V20, P1287, DOI 10.1002/hep.1840200528
   Imber CJ, 2002, LIVER TRANSPLANT, V8, P545, DOI 10.1053/jlts.2002.31747
   Imber CJ, 2002, LIVER TRANSPLANT, V8, P415, DOI 10.1053/jlts.2002.32275
   International Obesity Task Force, GLOB CHALL OB INT OB
   Ioannou GN, 2003, GASTROENTEROLOGY, V125, P1053, DOI 10.1016/S0016-5085(03)01200-9
   Jones CA, 1998, AM J KIDNEY DIS, V32, P992, DOI 10.1016/S0272-6386(98)70074-5
   KEARNEY JF, 2003, ARTERIOSCLER THROMB, V23, P434
   Krowka MJ, 2000, LIVER TRANSPLANT, V6, P443, DOI 10.1053/jlts.2000.6356
   Laight DW, 1999, EUR J PHARMACOL, V377, P89, DOI 10.1016/S0014-2999(99)00407-0
   Letteron P, 1996, J HEPATOL, V24, P200, DOI 10.1016/S0168-8278(96)80030-4
   Marchetti P, 2000, J ENDOCRINOL INVEST, V23, P482, DOI 10.1007/BF03343761
   Marfella R, 2001, J CLIN INVEST, V108, P635, DOI 10.1172/JCI0113727A
   Marsman WA, 1996, TRANSPLANTATION, V62, P1246, DOI 10.1097/00007890-199611150-00011
   MOLLOY RM, 1997, LIVER TRANSPLANT, V3, P117
   MORRIS CK, 1991, AM HEART J, V122, P1423, DOI 10.1016/0002-8703(91)90586-7
   Nair S, 2002, HEPATOLOGY, V35, P105, DOI 10.1053/jhep.2002.30318
   *NAT CTR CHRON DIS, 2003, DEF OV OB
   *NAT CTR INF DIS, 2003, VIR HEP C FACT SHEET
   Neuschwander-Tetri BA, 2003, HEPATOLOGY, V38, P1008, DOI 10.1053/jhep.2003.50420
   Neuschwander-Tetri BA, 2003, HEPATOLOGY, V37, P1202, DOI 10.1053/jhep.2003.50193
   Ortiz V, 2002, AM J GASTROENTEROL, V97, P2408, DOI 10.1111/j.1572-0241.2002.05995.x
   Pagano G, 2002, HEPATOLOGY, V35, P367, DOI 10.1053/jhep.2002.30690
   Painter P, 2001, LIVER TRANSPLANT, V7, P213, DOI 10.1053/jlts.2001.22184
   Poonawala A, 2000, HEPATOLOGY, V32, P689, DOI 10.1053/jhep.2000.17894
   POWELL EE, 1990, HEPATOLOGY, V11, P74, DOI 10.1002/hep.1840110114
   Ramsay M A, 1997, Liver Transpl Surg, V3, P494, DOI 10.1053/jlts.1997.v3.pm0009346791
   Ratziu V, 2000, GASTROENTEROLOGY, V118, P1117, DOI 10.1016/S0016-5085(00)70364-7
   Raynard B, 2002, HEPATOLOGY, V35, P635, DOI 10.1053/jhep.2002.31782
   Reilly MP, 1998, CIRCULATION, V98, P2822, DOI 10.1161/01.CIR.98.25.2822
   Rinella ME, 2001, LIVER TRANSPLANT, V7, P409, DOI 10.1053/jlts.2001.23787
   Rösen P, 2001, DIABETES-METAB RES, V17, P189, DOI 10.1002/dmrr.196
   Ryan CK, 2002, LIVER TRANSPLANT, V8, P1114, DOI 10.1053/jlts.2002.36740
   Saksena S, 2003, HEPATOLOGY, V38, p232A
   Sanyal AJ, 2001, GASTROENTEROLOGY, V120, P1183, DOI 10.1053/gast.2001.23256
   Schunkert H, 2002, INT J OBESITY, V26, pS15, DOI 10.1038/sj.ijo.0802214
   Seki S, 2002, J HEPATOL, V37, P56, DOI 10.1016/S0168-8278(02)00073-9
   Shields PL, 1999, TRANSPLANTATION, V68, P530, DOI 10.1097/00007890-199908270-00015
   Soltys K, 2001, HEPATOLOGY, V34, P13, DOI 10.1053/jhep.2001.25452
   TODO S, 1989, TRANSPLANTATION, V47, P903, DOI 10.1097/00007890-198905000-00034
   Trotter JF, 2001, LIVER TRANSPLANT, V7, P415, DOI 10.1053/jlts.2001.24933
   Tsigos C, 1999, METABOLISM, V48, P1332, DOI 10.1016/S0026-0495(99)90277-9
   *UNOS, 2000, LIV TRANSPL WAIT LIS
   Urena MAG, 1999, HEPATO-GASTROENTEROL, V46, P1164
   WADA K, 1974, ACTA PATHOL JAPON, V24, P207
   WANLESS IR, 1990, HEPATOLOGY, V12, P1106, DOI 10.1002/hep.1840120505
   Watt KDS, 2003, LIVER TRANSPLANT, V9, P1019, DOI 10.1053/jlts.2003.50206
NR 78
TC 144
Z9 157
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1600-6135
EI 1600-6143
J9 AM J TRANSPLANT
JI Am. J. Transplant.
PD MAY
PY 2004
VL 4
IS 5
BP 686
EP 693
DI 10.1111/j.1600-6143.2004.00432.x
PG 8
WC Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Transplantation
GA 818CT
UT WOS:000221223900005
PM 15084161
DA 2025-06-11
ER

PT J
AU Cazzola, M
   Bettoncelli, G
   Sessa, E
   Cricelli, C
   Biscione, G
AF Cazzola, Mario
   Bettoncelli, Germano
   Sessa, Emiliano
   Cricelli, Claudio
   Biscione, Gianluca
TI Prevalence of Comorbidities in Patients with Chronic Obstructive
   Pulmonary Disease
SO RESPIRATION
LA English
DT Article
DE Cardiovascular events; Chronic obstructive pulmonary disease;
   Depression; Osteoporosis
ID BONE-MINERAL DENSITY; CARDIOVASCULAR-DISEASE; SYSTEMIC INFLAMMATION;
   ARTERIAL STIFFNESS; METABOLIC SYNDROME; COPD; RISK; OSTEOPOROSIS;
   DEPRESSION; ANXIETY
AB Background: Chronic obstructive pulmonary disease (COPD) is associated with many comorbidities, but the percentage of COPD patients who develop comorbidities has not been clearly defined.
   Objectives: We aimed to examine the relationship between COPD and comorbidities using information obtained from the Health Search Database (HSD) owned by the Italian College of General Practitioners (SIMG), which stores information on about 1.5% of the total Italian population served by general practitioners.
   Methods: We conducted a population-based retrospective study using information obtained from the HSD. The software system used codes all the diagnostic records using the 9th Revision of the International Classification of Diseases.
   Results: Compared to the non-COPD people, COPD patients were at increased risk for cardiovascular events [ischemic heart disease (6.9% in the general population vs. 13.6% in COPD patients), cardiac arrhythmia (6.6% in the general population vs. 15.9% in COPD patients), heart failure (2.0% in the general population vs. 7.9% in COPD patients), and other forms of heart disease (10.7% in the general population vs. 23.1% in COPD patients); with a higher impact of COPD in the elderly]; non-psychotic mental disorders, including depressive disorders (29.1% in the general population vs. 41.6% in COPD patients; with a higher impact of COPD on women aged < 75 years); diabetes mellitus (10.5% in the general population vs. 18.7% in COPD patients); osteoporosis (10.8% in the general population vs. 14.8% in COPD patients), with a higher impact of COPD on women aged < 75 years, and malignant pulmonary neoplasms (0.4% in the general population vs. 1.9% in COPD patients).
   Conclusions: Our results indicate that COPD is a risk factor for these comorbid conditions. Copyright (C) 2010 S. Karger AG, Basel
C1 [Cazzola, Mario] Univ Roma Tor Vergata, Dipartimento Med Interna, Cattedra Malattie Resp, Div Resp Dis, IT-00133 Rome, Italy.
   [Cazzola, Mario] San Raffaele Pisana Hosp, Pulm Rehabil Grp, Rome, Italy.
   [Bettoncelli, Germano; Sessa, Emiliano; Cricelli, Claudio] Italian Coll Gen Practitioners, Hlth Search Inst, Florence, Italy.
   [Biscione, Gianluca] Hosp San Raffaele, Div Pulm Rehabil, Velletri, Italy.
C3 University of Rome Tor Vergata; Vita-Salute San Raffaele University;
   IRCCS Ospedale San Raffaele; Vita-Salute San Raffaele University; IRCCS
   Ospedale San Raffaele
RP Cazzola, M (corresponding author), Univ Roma Tor Vergata, Dipartimento Med Interna, Cattedra Malattie Resp, Div Resp Dis, Via Montpellier 1, IT-00133 Rome, Italy.
EM mario.cazzola@uniroma2.it
RI Cazzola, Mario/G-9397-2012; CRICELLI, Claudio/E-7607-2010
OI CRICELLI, Claudio/0000-0002-9607-5802
CR Agustí AGN, 2003, EUR RESPIR J, V21, P347, DOI 10.1183/09031936.03.00405703
   Agusti Alvar, 2007, Proc Am Thorac Soc, V4, P522, DOI 10.1513/pats.200701-004FM
   Agusti Alvar, 2006, Proc Am Thorac Soc, V3, P478, DOI 10.1513/pats.200603-058MS
   Biskobing DM, 2002, CHEST, V121, P609, DOI 10.1378/chest.121.2.609
   Bolton CE, 2004, AM J RESP CRIT CARE, V170, P1286, DOI 10.1164/rccm.200406-754OC
   Buffon A, 2002, NEW ENGL J MED, V347, P5, DOI 10.1056/NEJMoa012295
   Caramori G, 2007, Monaldi Arch Chest Dis, V67, P15
   Cauley JA, 2007, J BONE MINER RES, V22, P1816, DOI 10.1359/JBMR.070713
   Cazzola M, 2009, RESP MED, V103, P582, DOI 10.1016/j.rmed.2008.10.017
   Curkendall SM, 2006, ANN EPIDEMIOL, V16, P63, DOI 10.1016/j.annepidem.2005.04.008
   De Martinis M, 2005, FEBS LETT, V579, P2035, DOI 10.1016/j.febslet.2005.02.055
   de Torres JP, 2006, EUR RESPIR J, V27, P902, DOI 10.1183/09031936.06.00109605
   DEYO RA, 1992, J CLIN EPIDEMIOL, V45, P613, DOI 10.1016/0895-4356(92)90133-8
   Fabbri LM, 2008, EUR RESPIR J, V31, P204, DOI 10.1183/09031936.00114307
   Fabbri LM, 2007, LANCET, V370, P797, DOI 10.1016/S0140-6736(07)61383-X
   Filippi A, 2003, STROKE, V34, P1010, DOI 10.1161/01.STR.0000062888.90293.AA
   Gan WQ, 2004, THORAX, V59, P574, DOI 10.1136/thx.2003.019588
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hill K, 2008, EUR RESPIR J, V31, P667, DOI 10.1183/09031936.00125707
   Hole DJ, 1996, BRIT MED J, V313, P711
   Jorgensen NR, 2007, RESP MED, V101, P177, DOI 10.1016/j.rmed.2006.03.029
   Katz A, 2006, HEALTH SERV RES, V41, P2238, DOI 10.1111/j.1475-6773.2006.00589.x
   Kunik ME, 2005, CHEST, V127, P1205, DOI 10.1378/chest.127.4.1205
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Laurent S, 2005, HYPERTENSION, V45, P1050, DOI 10.1161/01.HYP.0000164580.39991.3d
   Lawrenson R, 1999, J PUBLIC HEALTH MED, V21, P299, DOI 10.1093/pubmed/21.3.299
   Li LH, 2008, COPD, V5, P291, DOI 10.1080/15412550802363329
   Macnee William, 2008, Proc Am Thorac Soc, V5, P824, DOI 10.1513/pats.200807-071TH
   Maurer J, 2008, CHEST, V134, p43S, DOI 10.1378/chest.08-0342
   Murphy CA, 2009, RESPIRATION, V78, P263, DOI 10.1159/000203354
   Piehl-Aulin K, 2009, RESPIRATION, V78, P191, DOI 10.1159/000207793
   Rodriguez-Roisin Roberto, 2008, Proc Am Thorac Soc, V5, P842, DOI 10.1513/pats.200807-075TH
   Roman MJ, 2005, HYPERTENSION, V46, P194, DOI 10.1161/01.HYP.0000168055.89955.db
   Sabit R, 2007, AM J RESP CRIT CARE, V175, P1259, DOI 10.1164/rccm.200701-067OC
   Schulz E, 2004, J CLIN ENDOCR METAB, V89, P4246, DOI 10.1210/jc.2003-030964
   Sevenoaks MJ, 2006, RESP RES, V7, DOI 10.1186/1465-9921-7-70
   Sichletidis Lazaros, 2007, Prim Care Respir J, V16, P82, DOI 10.3132/pcrj.2007.00016
   Sin DD, 2005, CAN J PHYSIOL PHARM, V83, P8, DOI 10.1139/Y04-116
   Sin DD, 2003, CIRCULATION, V107, P1514, DOI 10.1161/01.CIR.0000056767.69054.B3
   Soriano JB, 2005, CHEST, V128, P2099, DOI 10.1378/chest.128.4.2099
   Tankó LB, 2003, CALCIFIED TISSUE INT, V73, P15, DOI 10.1007/s00223-002-2070-x
   Tkac Jan, 2007, Ther Adv Respir Dis, V1, P47, DOI 10.1177/1753465807082374
   van den Hooven Caroline, 2006, Can Fam Physician, V52, P982
   van Eeden SF, 2008, RESPIRATION, V75, P224, DOI 10.1159/000111820
   van Weel C, 2006, LANCET, V367, P550, DOI 10.1016/S0140-6736(06)68198-1
   World Health Organization, 1977, INT CLASS DIS MAN IN
   Wouters EFM, 2002, CHEST, V121, p127S, DOI 10.1378/chest.121.5_suppl.127S
NR 47
TC 163
Z9 168
U1 0
U2 10
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0025-7931
EI 1423-0356
J9 RESPIRATION
JI Respiration
PY 2010
VL 80
IS 2
BP 112
EP 119
DI 10.1159/000281880
PG 8
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA 621OX
UT WOS:000279591100005
PM 20134148
OA Bronze
DA 2025-06-11
ER

PT J
AU Sánchez-Villegas, A
   Martínez-González, MA
   Estruch, R
   Salas-Salvadó, J
   Corella, D
   Covas, MI
   Arós, F
   Romaguera, D
   Gómez-Gracia, E
   Lapetra, J
   Pintó, X
   Martínez, JA
   Lamuela-Raventós, RM
   Ros, E
   Gea, A
   Wärnberg, J
   Serra-Majem, L
AF Sanchez-Villegas, Almudena
   Angel Martinez-Gonzalez, Miguel
   Estruch, Ramon
   Salas-Salvado, Jordi
   Corella, Dolores
   Isabel Covas, Maria
   Aros, Fernando
   Romaguera, Dora
   Gomez-Gracia, Enrique
   Lapetra, Jose
   Pinto, Xavier
   Alfredo Martinez, Jose
   Maria Lamuela-Raventos, Rosa
   Ros, Emilio
   Gea, Alfredo
   Waernberg, Julia
   Serra-Majem, Lluis
TI Mediterranean dietary pattern and depression: the PREDIMED randomized
   trial
SO BMC MEDICINE
LA English
DT Article
DE Mediterranean diet; Depression; Trial; Primary prevention; Nuts; Olive
   oil; Low-fat; Diabetes
ID BODY-MASS INDEX; METABOLIC SYNDROME; ENDOTHELIAL DYSFUNCTION;
   INSULIN-RESISTANCE; RISK-FACTORS; ASSOCIATION; SYMPTOMS; LEPTIN; WOMEN;
   METAANALYSIS
AB Background: A few observational studies have found an inverse association between adherence to a Mediterranean diet and the risk of depression. Randomized trials with an intervention based on this dietary pattern could provide the most definitive answer to the findings reported by observational studies. The aim of this study was to compare in a randomized trial the effects of two Mediterranean diets versus a low-fat diet on depression risk after at least 3 years of intervention.
   Methods: This was a multicenter, randomized, primary prevention field trial of cardiovascular disease (Prevencion con Dieta Mediterranea (PREDIMED Study)) based on community-dwelling men aged 55 to 80 years and women aged 60 to 80 years at high risk of cardiovascular disease (51% of them had type 2 diabetes; DM2) attending primary care centers affiliated with 11 Spanish teaching hospitals. Primary analyses were performed on an intention-to-treat basis. Cox regression models were used to assess the relationship between the nutritional intervention groups and the incidence of depression.
   Results: We identified 224 new cases of depression during follow-up. There was an inverse association with depression for participants assigned to a Mediterranean diet supplemented with nuts (multivariate hazard ratio (HR) 0.78; 95% confidence interval (CI) 0.55 to 1.10) compared with participants assigned to the control group, although this was not significant. However, when the analysis was restricted to participants with DM2, the magnitude of the effect of the intervention with the Mediterranean diet supplemented with nuts did reach statistical significance (multivariate HR = 0.59; 95% CI 0.36 to 0.98).
   Conclusions: The result suggest that a Mediterranean diet supplemented with nuts could exert a beneficial effect on the risk of depression in patients with DM2.
   Trial registration: This trial has been registered in the Current Controlled Trials with the number ISRCTN 35739639
C1 [Sanchez-Villegas, Almudena; Angel Martinez-Gonzalez, Miguel; Estruch, Ramon; Salas-Salvado, Jordi; Corella, Dolores; Isabel Covas, Maria; Aros, Fernando; Romaguera, Dora; Gomez-Gracia, Enrique; Lapetra, Jose; Pinto, Xavier; Alfredo Martinez, Jose; Maria Lamuela-Raventos, Rosa; Ros, Emilio; Gea, Alfredo; Waernberg, Julia; Serra-Majem, Lluis] Biomed Res Ctr Network Obes & Nutr CIBERobn Physi, Inst Hlth Carlos 3, Madrid, Spain.
   [Sanchez-Villegas, Almudena; Serra-Majem, Lluis] Univ Las Palmas Gran Canaria, Dept Clin Sci, Las Palmas Gran Canaria 35080, Spain.
   [Angel Martinez-Gonzalez, Miguel; Gea, Alfredo] Univ Navarra, Dept Prevent Med & Publ Hlth, E-31080 Pamplona, Spain.
   [Estruch, Ramon] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAP, Dept Internal Med, Barcelona, Spain.
   [Salas-Salvado, Jordi] Univ Rovira & Virgili, IISPV, Human Nutr Unit, E-43201 Reus, Spain.
   [Corella, Dolores] Univ Valencia, Dept Prevent Med, Valencia, Spain.
   [Isabel Covas, Maria] IMIM, Lipids & Cardiovasc Epidemiol Res Unit, Barcelona, Spain.
   [Aros, Fernando] Univ Hosp Txagorritxu, Dept Cardiol, Vitoria, Spain.
   [Romaguera, Dora] Univ Hosp Son Espases, Res Unit, Palma de Mallorca, Spain.
   [Romaguera, Dora] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London, England.
   [Gomez-Gracia, Enrique; Waernberg, Julia] Univ Malaga, Dept Prevent Med, E-29071 Malaga, Spain.
   [Lapetra, Jose] Ctr Salud San Pablo, Dept Family Med, Primary Care Div Sevilla, Seville, Spain.
   [Pinto, Xavier] Hosp Univ Bellvitge, Hosp Llobregat, Lipids & Vasc Risk Unit, Barcelona, Spain.
   [Alfredo Martinez, Jose] Univ Navarra, Dept Nutr & Food Sci Physiol & Toxicol, E-31080 Pamplona, Spain.
   [Maria Lamuela-Raventos, Rosa] Univ Barcelona, INSA, Nutr & Food Sci Dept XaRTA, Barcelona, Spain.
   [Ros, Emilio] Hosp Clin Barcelona, Lipid Clin, Dept Endocrinol & Nutr, Barcelona, Spain.
   [Ros, Emilio] Hosp Clin Barcelona, Inst Invest Biomed August Pi Sunyer IDIBAPS, Barcelona, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Universidad
   de Las Palmas de Gran Canaria; University of Navarra; University of
   Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Universitat Rovira i
   Virgili; Institut d'Investigacio Sanitaria Pere Virgili (IISPV);
   University of Valencia; Hospital del Mar Research Institute; University
   Hospital of Araba; Hospital Universitari Son Espases; Imperial College
   London; Universidad de Malaga; Institut d'Investigacio Biomedica de
   Bellvitge (IDIBELL); Bellvitge University Hospital; University of
   Navarra; University of Barcelona; University of Barcelona; Hospital
   Clinic de Barcelona; University of Barcelona; Hospital Clinic de
   Barcelona; IDIBAPS
RP Sánchez-Villegas, A (corresponding author), Biomed Res Ctr Network Obes & Nutr CIBERobn Physi, Inst Hlth Carlos 3, Madrid, Spain.
EM asanchez@dcc.ulpgc.es
RI Romaguera, Dora/AAB-2852-2020; Sanchez-Villegas, Almudena/T-6733-2019;
   Warnberg, Julia/G-1390-2011; Salas-Salvado, Jordi/C-7229-2017; Raventos,
   Rosa/F-3986-2016; Corella, Dolores/L-9888-2014; Pintó,
   Xavier/AGI-4297-2022; Abad-Gurumeta, Alfredo/M-2337-2019;
   Martinez-Gonzalez, Miguel/AAE-7669-2019; Serra-Majem, Lluis/I-6708-2019;
   Lapetra, Jose/F-2552-2015; Estruch, Ramon/AAZ-3723-2020
FU official funding agency for biomedical research of the Spanish
   government, Instituto de Salud Carlos III (ISCIII) [RTIC G03/140, RTIC
   RD 06/0045]; Centro Nacional de Investigaciones Cardiovasculares [CNIC
   06/2007]; Fondo de Investigacion Sanitaria-Fondo Europeo de Desarrollo
   Regional [PI04-2239, PI 05/2584, CP06/00100, PI07/0240, PI07/1138,
   PI07/0954, PI 07/0473, PI10/01407, PI10/02658, PI11/01647, P11/02505];
   Ministerio de Ciencia e Innovacion [AGL-2009-13906-C02,
   AGL2010-22319-C03]; Fundacion Mapfre; Consejeria de Salud de la Junta de
   Andalucia [PI0105/2007]; Public Health Division of the Department of
   Health of the Autonomous Government of Catalonia; Generalitat Valenciana
   [ACOMP06109, GVACOMP2010-181, GVACOMP2011-151, CS2010- AP-111,
   CS2011-AP-042]; Regional Government of Navarra [P27/2011]; Spanish
   Government; official funding agency for biomedical research of the
   Spanish government, Instituto de Salud Carlos III (ISCIII), through
   Centro de Investigacion Biomedica en Red de Fisiopatologia de la
   Obesidad y Nutricion (CIBERobn)
FX This study was supported by the official funding agency for biomedical
   research of the Spanish government, Instituto de Salud Carlos III
   (ISCIII), through grants provided to research networks specifically
   developed for the trial (RTIC G03/140 to RE, RTIC RD 06/0045 to MAMG,
   and through Centro de Investigacion Biomedica en Red de Fisiopatologia
   de la Obesidad y Nutricion (CIBERobn), and by grants from Centro
   Nacional de Investigaciones Cardiovasculares (CNIC 06/2007), Fondo de
   Investigacion Sanitaria-Fondo Europeo de Desarrollo Regional (PI04-2239,
   PI 05/2584, CP06/00100, PI07/0240, PI07/1138, PI07/0954, PI 07/0473,
   PI10/01407, PI10/02658, PI11/01647, and P11/02505), Ministerio de
   Ciencia e Innovacion (AGL-2009-13906-C02 and AGL2010-22319-C03),
   Fundacion Mapfre 2010, Consejeria de Salud de la Junta de Andalucia
   (PI0105/2007), Public Health Division of the Department of Health of the
   Autonomous Government of Catalonia, Generalitat Valenciana (ACOMP06109,
   GVACOMP2010-181, GVACOMP2011-151, CS2010- AP-111, and CS2011-AP-042),
   and Regional Government of Navarra (P27/2011). AG is supported by an FPU
   fellowship from the Spanish Government.
CR Ajala O, 2013, AM J CLIN NUTR, V97, P505, DOI 10.3945/ajcn.112.042457
   Akbaraly TN, 2013, DIABETES CARE, V36, P928, DOI 10.2337/dc12-0239
   Akbaraly TN, 2009, BRIT J PSYCHIAT, V195, P408, DOI 10.1192/bjp.bp.108.058925
   Martínez-González MA, 2012, INT J EPIDEMIOL, V41, P377, DOI 10.1093/ije/dyq250
   [Anonymous], PUBLIC HLTH NUTR
   Babio N, 2009, NUTR METAB CARDIOVAS, V19, P563, DOI 10.1016/j.numecd.2008.10.007
   Beltowski J, 2006, ATHEROSCLEROSIS, V189, P47, DOI 10.1016/j.atherosclerosis.2006.03.003
   Bocchio-Chiavetto L, 2010, WORLD J BIOL PSYCHIA, V11, P763, DOI 10.3109/15622971003611319
   Carter SJ, 2010, ATHEROSCLEROSIS, V210, P630, DOI 10.1016/j.atherosclerosis.2009.12.035
   Do DP, 2010, PSYCHOSOM MED, V72, P613, DOI 10.1097/PSY.0b013e3181e2cca5
   Elomaa AP, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-2
   ELOSUA R, 1994, AM J EPIDEMIOL, V139, P1197, DOI 10.1093/oxfordjournals.aje.a116966
   Estruch R, 2013, NEW ENGL J MED, V368, P1279, DOI 10.1056/NEJMoa1200303
   Estruch R, 2006, ANN INTERN MED, V145, P1, DOI 10.7326/0003-4819-145-1-200607040-00004
   FELDMAN JM, 1985, AM J CLIN NUTR, V42, P639, DOI 10.1093/ajcn/42.4.639
   Fernández-Ballarth JD, 2010, BRIT J NUTR, V103, P1808, DOI 10.1017/S0007114509993837
   Groenwold RHH, 2012, AM J EPIDEMIOL, V175, P210, DOI 10.1093/aje/kwr302
   Hood KK, 2012, DIABETES CARE, V35, P2443, DOI 10.2337/dc11-2329
   Jacka FN, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024805
   Jacka FN, 2011, PSYCHOSOM MED, V73, P483, DOI 10.1097/PSY.0b013e318222831a
   Jacka FN, 2010, AM J PSYCHIAT, V167, P305, DOI 10.1176/appi.ajp.2009.09060881
   Jeffery RW, 2009, APPETITE, V52, P238, DOI 10.1016/j.appet.2008.08.008
   Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213
   Krauss RM, 2000, CIRCULATION, V102, P2284
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Marin C, 2011, AM J CLIN NUTR, V93, P267, DOI 10.3945/ajcn.110.006866
   Mataix J., 2003, Tablas de composicion de alimentos, V4
   Mathers CD, 2006, GLOBAL BURDEN OF DISEASE AND RISK FACTORS, P45
   Milaneschi Y, 2012, J CLIN PSYCHIAT, V73, P1205
   Morris AA, 2012, PSYCHOSOM MED, V74, P483, DOI 10.1097/PSY.0b013e31824f5de0
   Morrison CD, 2009, BBA-MOL BASIS DIS, V1792, P401, DOI 10.1016/j.bbadis.2008.12.004
   Nanri A, 2010, EUR J CLIN NUTR, V64, P832, DOI 10.1038/ejcn.2010.86
   Oxenkrug GF, 2010, ANN NY ACAD SCI, V1199, P1, DOI 10.1111/j.1749-6632.2009.05356.x
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pasco JA, 2008, J AFFECT DISORDERS, V107, P221, DOI 10.1016/j.jad.2007.07.024
   Pérez-Martínez P, 2011, CURR PHARM DESIGN, V17, P769, DOI 10.2174/138161211795428948
   Pischon T, 2008, NEW ENGL J MED, V359, P2105, DOI 10.1056/NEJMoa0801891
   Porta N, 2007, J CLIN EPIDEMIOL, V60, P663, DOI 10.1016/j.jclinepi.2006.09.013
   Rienks J, 2013, EUR J CLIN NUTR, V67, P75, DOI 10.1038/ejcn.2012.193
   Sanchez-Villegas A, 2013, BMC MED, V11, DOI [10.1186/1741-7015-11-3, 10.1186/1741-7015-11-208]
   Sánchez-Villegas A, 2012, PUBLIC HEALTH NUTR, V15, P424, DOI 10.1017/S1368980011001856
   Sánchez-Villegas A, 2011, NUTR NEUROSCI, V14, P195, DOI 10.1179/1476830511Y.0000000011
   Sánchez-Villegas A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016268
   Sánchez-Villegas A, 2009, ARCH GEN PSYCHIAT, V66, P1090, DOI 10.1001/archgenpsychiatry.2009.129
   Sanhueza C, 2013, J HUM NUTR DIET, V26, P56, DOI 10.1111/j.1365-277X.2012.01283.x
   Schröder H, 2011, J NUTR, V141, P1140, DOI 10.3945/jn.110.135566
   Sugawara N, 2012, ANN GEN PSYCHIATR, V11, DOI 10.1186/1744-859X-11-24
   Mitjavila MT, 2013, CLIN NUTR, V32, P172, DOI 10.1016/j.clnu.2012.08.002
   Tulipani S, 2011, J PROTEOME RES, V10, P5047, DOI 10.1021/pr200514h
   Urpi-Sarda M, 2012, J NUTR, V142, P1019, DOI 10.3945/jn.111.148726
   Valkanova V, 2013, BIOL PSYCHIAT, V73, P406, DOI 10.1016/j.biopsych.2012.10.028
   Weng TT, 2012, PUBLIC HEALTH NUTR, V15, P673, DOI 10.1017/S1368980011003077
   WILLETT WC, 1995, AM J CLIN NUTR, V61, p1402S, DOI 10.1093/ajcn/61.6.1402S
   Williams KW, 2011, EUR J PHARMACOL, V660, P2, DOI 10.1016/j.ejphar.2010.11.042
   World Health Organization, 2008, GLOB BURD DIS 2004 U
   Zazpe I, 2008, J AM DIET ASSOC, V108, P1134, DOI 10.1016/j.jada.2008.04.011
   Zheng W, 2011, NEW ENGL J MED, V364, P719, DOI 10.1056/NEJMoa1010679
NR 57
TC 168
Z9 169
U1 2
U2 86
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1741-7015
J9 BMC MED
JI BMC Med.
PD SEP 20
PY 2013
VL 11
AR 208
DI 10.1186/1741-7015-11-208
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 221HQ
UT WOS:000324649100001
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hammer, T
   Kotolová, H
   Procházka, J
   Karpísek, M
AF Hammer, Tomas
   Kotolova, Hana
   Prochazka, Jiri
   Karpisek, Michal
TI Disruption of Lipid Profile, Glucose Metabolism, and Leptin Levels
   following Citalopram Administration and High-Carbohydrate and
   High-Cholesterol Diet in Mice
SO PHARMACOLOGY
LA English
DT Article
DE Adipokines; Citalopram; Dyslipidemia; Leptin; Metabolic syndrome; Mouse
ID SEROTONIN REUPTAKE INHIBITORS; PREMATURE EJACULATION; ESTROUS-CYCLE;
   DEPRESSION; ANXIETY; WEIGHT; ADIPONECTIN; EXPRESSION; SYMPTOMS; OBESITY
AB Introduction: Depression therapy has been linked to negative effects on energy metabolism, which can be attributed to various factors, including an ongoing inflammatory process commonly seen in metabolic disorders. Unhealthy lifestyle choices of patients and the impact of antidepressants on body weight and lipid and glucose metabolism also contribute to these metabolic side effects. Although not as pronounced as other psychopharmaceuticals, the increasing use of antidepressants raises concerns about their potential impact on public health. The study aimed to evaluate the short- and long-term effects of the antidepressant citalopram and its long-term combination with a special diet on metabolic parameters in mice. Methods: Animals were randomly divided into 5 groups - control, control + special diet, citalopram (10 mg/kg for 35 days), citalopram + special diet (10 mg/kg for 35 days), and citalopram (10 mg/kg for 7 days). After a described time of administration, animals were anesthetized, blood and fat and liver tissues were collected. Biochemical parameters of lipid metabolism (total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides) and glucose were analyzed using spectrophotometry and relevant adipokines and cytokines were evaluated by ELISA. Results: After a week of application of citalopram, we observed dyslipidemia that persisted even at the end of the 5-week experiment. Furthermore, after 5 weeks of citalopram administration, we observed a significant decrease in body weight gain and decreased leptin levels. Changes in lipid metabolism, higher levels of adipokines leptin and PAI-1 were observed due to the special diet after 5 weeks. Conclusions: Our research suggests that the effects of citalopram and a diet on the metabolism of mice can be significant, both in the short term (1 week) and in the long term (5 weeks).
C1 [Hammer, Tomas; Kotolova, Hana; Prochazka, Jiri; Karpisek, Michal] Masaryk Univ, Fac Pharm, Dept Pharmacol & Toxicol, Brno, Czech Republic.
   [Hammer, Tomas; Kotolova, Hana; Prochazka, Jiri; Karpisek, Michal] Univ Vet & Pharmaceut Sci Brno, Fac Pharm, Dept Human Pharmacol & Toxicol, Brno, Czech Republic.
   [Karpisek, Michal] BioVendor Laboratorni Med A s, Res & Diagnost Prod Div, Brno, Czech Republic.
C3 Masaryk University Brno; University of Veterinary Sciences Brno
RP Hammer, T (corresponding author), Masaryk Univ, Fac Pharm, Dept Pharmacol & Toxicol, Brno, Czech Republic.; Hammer, T (corresponding author), Univ Vet & Pharmaceut Sci Brno, Fac Pharm, Dept Human Pharmacol & Toxicol, Brno, Czech Republic.
EM hammert@pharm.muni.cz
FU University of Veterinary and Pharmaceutical Sciences Brno [IGA
   316/2017/FAF]
FX This research was supported by project IGA 316/2017/FAF of the
   University of Veterinary and Pharmaceutical Sciences Brno.
CR Aggarwal A, 2016, J CLIN DIAGN RES, V10, pAF1, DOI 10.7860/JCDR/2016/16482.7376
   Alonso-Pedrero L, 2019, OBES REV, V20, P1680, DOI 10.1111/obr.12934
   Archanco M, 2003, J HISTOCHEM CYTOCHEM, V51, P1269, DOI 10.1177/002215540305101003
   Arterburn D, 2016, J CLIN MED, V5, DOI 10.3390/jcm5040048
   Atmaca M, 2003, BJU INT, V91, P252, DOI 10.1046/j.1464-410X.2003.04052.x
   Barim AO, 2009, CLIN BIOCHEM, V42, P1076, DOI 10.1016/j.clinbiochem.2009.02.020
   Beyazyüz M, 2013, PSYCHIAT INVEST, V10, P148, DOI 10.4306/pi.2013.10.2.148
   Capuron L, 2017, NEUROPSYCHOPHARMACOL, V42, P115, DOI 10.1038/npp.2016.123
   Carvalho AF, 2014, J PSYCHIATR RES, V59, P28, DOI 10.1016/j.jpsychires.2014.08.002
   Colotto M, 2012, CLIN TER, V163, pE41
   da Silva AI, 2019, BEHAV BRAIN RES, V356, P62, DOI 10.1016/j.bbr.2018.08.007
   De Hert M, 2009, EUR PSYCHIAT, V24, P412, DOI 10.1016/j.eurpsy.2009.01.005
   Della Torre S, 2016, CELL REP, V15, P360, DOI 10.1016/j.celrep.2016.03.019
   Feng XM, 2012, CNS NEUROSCI THER, V18, P974, DOI 10.1111/cns.12014
   Ferguson JM, 2001, J CLIN PSYCHIAT, V62, P22
   Gafoor R, 2018, BMJ-BRIT MED J, V361, DOI 10.1136/bmj.k1951
   Geiser F, 2011, PSYCHIAT CLIN NEUROS, V65, P518, DOI 10.1111/j.1440-1819.2011.02241.x
   Giles ED, 2010, AM J PHYSIOL-REG I, V299, pR1634, DOI 10.1152/ajpregu.00219.2010
   Gui YT, 2006, CAN J PHYSIOL PHARM, V84, P887, DOI 10.1139/Y06-032
   Habegger KM, 2010, NAT REV ENDOCRINOL, V6, P689, DOI 10.1038/nrendo.2010.187
   Horska Katerina, 2014, Ceska Slov Farm, V63, P152
   Hu SM, 2018, CELL METAB, V28, P415, DOI 10.1016/j.cmet.2018.06.010
   Jiang HT, 2016, SCI REP-UK, V6, DOI 10.1038/srep30464
   Kolcsár M, 2016, FARMACIA, V64, P599
   Kotolov H., 2019, PSYCHIATR PROPRAXI, V20, P60
   Kucerova J, 2015, BIOMED PAP, V159, P208, DOI 10.5507/bp.2014.060
   Lawson EA, 2012, CLIN ENDOCRINOL, V76, P520, DOI 10.1111/j.1365-2265.2011.04182.x
   Lu H, 2022, LIPIDS HEALTH DIS, V21, DOI 10.1186/s12944-022-01654-6
   Mulugeta A, 2020, MOL PSYCHIATR, V25, P1469, DOI 10.1038/s41380-019-0486-1
   Nikoobakht MR, 2008, J SEX MED, V5, P2942, DOI 10.1111/j.1743-6109.2007.00730.x
   Raeder MB, 2006, J CLIN PSYCHIAT, V67, P1974, DOI 10.4088/JCP.v67n1219
   Raeder MB, 2006, NEUROSCI LETT, V395, P185, DOI 10.1016/j.neulet.2005.10.096
   Rygula R, 2006, BEHAV PHARMACOL, V17, P19, DOI 10.1097/01.fbp.0000186631.53851.71
   Saavedra-Peña RD, 2023, CELL REP, V42, DOI 10.1016/j.celrep.2023.112390
   Shi ZM, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2017-016224
   Speakman JR, 2019, INT J OBESITY, V43, P1491, DOI 10.1038/s41366-019-0363-7
   Takahashi M, 1999, J NUTR SCI VITAMINOL, V45, P583, DOI 10.3177/jnsv.45.583
   Takahashi Y, 2012, WORLD J GASTROENTERO, V18, P2300, DOI 10.3748/wjg.v18.i19.2300
   Weber-Hamann B, 2007, J PSYCHIATR RES, V41, P344, DOI 10.1016/j.jpsychires.2006.01.002
   Yabe D, 2011, PROG BIOPHYS MOL BIO, V107, P248, DOI 10.1016/j.pbiomolbio.2011.07.010
   Yu DS, 2018, J CELL PHYSIOL, V233, P4770, DOI 10.1002/jcp.26270
   Zemdegs J, 2016, BRIT J PHARMACOL, V173, P2095, DOI 10.1111/bph.13343
NR 42
TC 1
Z9 1
U1 1
U2 5
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0031-7012
EI 1423-0313
J9 PHARMACOLOGY
JI Pharmacology
PD APR
PY 2025
VL 110
IS 2
BP 87
EP 97
DI 10.1159/000541229
EA SEP 2024
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 1QB2M
UT WOS:001324929200001
PM 39236683
OA hybrid
DA 2025-06-11
ER

PT J
AU Talbot, LS
   Neylan, TC
   Metzler, TJ
   Cohen, BE
AF Talbot, Lisa S.
   Neylan, Thomas C.
   Metzler, Thomas J.
   Cohen, Beth E.
TI The Mediating Effect of Sleep Quality on the Relationship between PTSD
   and Physical Activity
SO JOURNAL OF CLINICAL SLEEP MEDICINE
LA English
DT Article
DE posttraumatic stress disorder; sleep quality; physical activity
ID POSTTRAUMATIC-STRESS-DISORDER; CORONARY-HEART-DISEASE; NATIONALLY
   REPRESENTATIVE SAMPLE; METABOLIC SYNDROME; HEALTH BEHAVIORS;
   GENERAL-POPULATION; VIETNAM VETERANS; WEIGHT-GAIN; RISK; ASSOCIATION
AB Study Objectives: Physical inactivity is linked to health outcomes such as obesity, diabetes, and psychiatric disorders. Sleep disturbance has been linked to the same adverse outcomes. We examine the influence of sleep on physical activity as a novel approach to understand these relationships. Specifically, our objective was to determine whether low sleep quality predicts low physical activity in posttraumatic stress disorder (PTSD), a disorder associated with sleep disturbance, physical inactivity, and poor health outcomes.
   Methods: We used data from the Mind Your Heart Study, a prospective cohort study of 736 outpatients recruited from two Department of Veterans Affairs (VA) medical centers. We assessed PTSD with the Clinician Administered PTSD Scale, sleep quality using an item from the Pittsburgh Sleep Quality Index, and physical activity by self-report at baseline and again one year later. Hierarchical multiple regression models and structural equation modeling were used to examine the relationships among PTSD, sleep, and physical activity.
   Results: Sleep quality but not PTSD status was prospectively associated with lower physical activity in a model adjusting for age, sex, apnea probability, depression, body mass index, and baseline physical activity (beta = 0.129, SE = 0.072, p < 0.01). Structural equation modeling indicated that the results were consistent with sleep quality statistically mediating the relationship between PTSD status at baseline and physical activity one year later.
   Conclusions: Worse sleep quality predicts lower physical activity in PTSD, providing possible evidence for a behavioral pathway from disturbed sleep to poor physical health outcomes.
C1 [Talbot, Lisa S.; Neylan, Thomas C.; Metzler, Thomas J.; Cohen, Beth E.] San Francisco VA Med Ctr, San Francisco, CA USA.
   [Talbot, Lisa S.; Neylan, Thomas C.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA.
   [Cohen, Beth E.] Univ Calif San Francisco, Dept Med, San Francisco, CA USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   San Francisco VA Medical Center; University of California System;
   University of California San Francisco; University of California System;
   University of California San Francisco
RP Talbot, LS (corresponding author), San Francisco VA Med Ctr 116H, 4150 Clement St, San Francisco, CA 94121 USA.
EM lisa.talbot@gmail.com
FU National Heart, Lung, and Blood Institute [K23 HL 094765]; Irene
   Perstein Foundation; Mental Illness Research and Education Clinical
   Center of the US Veterans Health Administration
FX This was not an industry supported study. This research was supported by
   grants from the National Heart, Lung, and Blood Institute (BEC: K23 HL
   094765), the Irene Perstein Foundation, and the Mental Illness Research
   and Education Clinical Center of the US Veterans Health Administration.
   The authors have indicated no financial conflicts of interest.
CR Aadahl M, 2007, EUR J CARDIOV PREV R, V14, P422, DOI 10.1097/HJR.0b013e3280128d00
   AINSWORTH BE, 1993, MED SCI SPORT EXER, V25, P71, DOI 10.1249/00005768-199301000-00011
   Babson KA, 2012, J TRAUMA STRESS, V25, P665, DOI 10.1002/jts.21757
   Baron KG, 2013, J CLIN SLEEP MED, V9, P819, DOI 10.5664/jcsm.2930
   BLAKE DD, 1995, J TRAUMA STRESS, V8, P75, DOI 10.1007/BF02105408
   BLANCHARD EB, 1994, BEHAV RES THER, V32, P283, DOI 10.1016/0005-7967(94)90123-6
   Bromley LE, 2012, SLEEP, V35, P977, DOI 10.5665/sleep.1964
   Buckley TC, 2004, MIL MED, V169, P536, DOI 10.7205/MILMED.169.7.536
   Bush K, 1998, ARCH INTERN MED, V158, P1789, DOI 10.1001/archinte.158.16.1789
   Buysse DJ, 2006, SLEEP, V29, P1155, DOI 10.1093/sleep/29.9.1155
   Buysse DJ, 2014, SLEEP, V37, P9, DOI 10.5665/sleep.3298
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1016/0165-1781(89)90047-4
   Caska CM, 2009, PSYCHOSOM MED, V71, P280, DOI 10.1097/PSY.0b013e31819b6a08
   Chandola T, 2010, SLEEP, V33, P739, DOI 10.1093/sleep/33.6.739
   Chaput JP, 2011, SLEEP, V34, P1291, DOI 10.5665/SLEEP.1264
   Chwastiak LA, 2011, PSYCHOSOMATICS, V52, P230, DOI 10.1016/j.psym.2010.12.009
   de Assis MA, 2008, CLINICS, V63, P473, DOI 10.1590/S1807-59322008000400010
   Driver HS, 2000, SLEEP MED REV, V4, P387, DOI 10.1053/smrv.2000.0110
   Edinger Jack D., 2004, Sleep (Rochester), V27, P1567
   Erickson KI, 2011, P NATL ACAD SCI USA, V108, P3017, DOI 10.1073/pnas.1015950108
   Evans DS, 2011, SLEEP, V34, P661, DOI 10.1093/sleep/34.5.661
   Germain A, 2004, J TRAUMA STRESS, V17, P477, DOI 10.1007/s10960-004-5796-6
   Gupta NK, 2002, AM J HUM BIOL, V14, P762, DOI 10.1002/ajhb.10093
   Harvey AG, 2008, SLEEP, V31, P383, DOI 10.1093/sleep/31.3.383
   Hoevenaar-Blom MP, 2011, SLEEP, V34, P1487, DOI 10.5665/sleep.1382
   Imaki Masahide, 2002, Journal of Physiological Anthropology and Applied Human Science, V21, P115, DOI 10.2114/jpa.21.115
   Jennings JR, 2007, SLEEP, V30, P219, DOI 10.1093/sleep/30.2.219
   Jin H, 2009, J CLIN PSYCHOPHARM, V29, P210, DOI 10.1097/JCP.0b013e3181a45ed0
   Krakow B, 2001, JAMA-J AM MED ASSOC, V286, P537, DOI 10.1001/jama.286.5.537
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Krystal AD, 2008, SLEEP MED, V9, pS10, DOI 10.1016/S1389-9457(08)70011-X
   Kubzansky LD, 2007, ARCH GEN PSYCHIAT, V64, P109, DOI 10.1001/archpsyc.64.1.109
   MAISLIN G, 1995, SLEEP, V18, P158, DOI 10.1093/sleep/18.3.158
   Marshall RD, 2001, AM J PSYCHIAT, V158, P1467, DOI 10.1176/appi.ajp.158.9.1467
   Neylan TC, 1998, AM J PSYCHIAT, V155, P929, DOI 10.1176/ajp.155.7.929
   Oeland AM, 2010, NORD J PSYCHIAT, V64, P210, DOI 10.3109/08039480903511373
   Ohayon MM, 2000, COMPR PSYCHIAT, V41, P469, DOI 10.1053/comp.2000.16568
   Ohida T, 2001, SLEEP, V24, P333, DOI 10.1093/sleep/24.3.333
   Pagoto SL, 2012, OBESITY, V20, P200, DOI 10.1038/oby.2011.318
   Patel SR, 2008, OBESITY, V16, P643, DOI 10.1038/oby.2007.118
   Penev PD, 2012, J CLIN ENDOCR METAB, V97, P1792, DOI 10.1210/jc.2012-1067
   ROSZELL DK, 1991, HOSP COMMUNITY PSYCH, V42, P293
   Spiegel K, 2005, J APPL PHYSIOL, V99, P2008, DOI 10.1152/japplphysiol.00660.2005
   Troxel WM, 2010, SLEEP, V33, P1633, DOI 10.1093/sleep/33.12.1633
   Vgontzas AN, 2009, SLEEP, V32, P491, DOI 10.1093/sleep/32.4.491
   Weathers FW, 2001, DEPRESS ANXIETY, V13, P132, DOI 10.1002/da.1029
   Whooley MA, 2008, JAMA-J AM MED ASSOC, V300, P2379, DOI 10.1001/jama.2008.711
   Youngstedt SD, 1997, SLEEP, V20, P203, DOI 10.1093/sleep/20.3.203
   Zen AL, 2012, HEALTH PSYCHOL, V31, P194, DOI 10.1037/a0025989
   Zschucke Elisabeth, 2013, J Prev Med Public Health, V46 Suppl 1, pS12, DOI 10.3961/jpmph.2013.46.S.S12
NR 50
TC 43
Z9 49
U1 6
U2 34
PU AMER ACAD SLEEP MEDICINE
PI DARIEN
PA 2510 N FRONTAGE RD, DARIEN, IL 60561 USA
SN 1550-9389
EI 1550-9397
J9 J CLIN SLEEP MED
JI J. Clin. Sleep Med.
PY 2014
VL 10
IS 7
BP 795
EP 801
DI 10.5664/jcsm.3878
PG 7
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA AO2GN
UT WOS:000341136100014
PM 25024659
OA Bronze, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Krogh, J
   Speyer, H
   Norgaard, HCB
   Moltke, A
   Nordentoft, M
AF Krogh, Jesper
   Speyer, Helene
   Norgaard, Hans Christian Brix
   Moltke, Ane
   Nordentoft, Merete
TI Can exercise increase fitness and reduce weight in patients with
   schizophrenia and depression?
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE exercise therapy; schizophrenia; depression; randomised controlled
   trials; weight loss
AB Background: Psychiatric patients have a reduced life expectancy of 15-20?years compared with the general population. Most years of lost life are due to the excess mortality from somatic diseases. Sedentary lifestyle and medication is partly responsible for the high frequency of metabolic syndrome in this patient group and low levels of physical activity is associated with increased risk of cardiovascular disease, diabetes, and all-cause mortality. This study aimed to review trials allocating patients with either schizophrenia or depression to exercise interventions for effect on cardiovascular fitness, strength, and weight.
   Methods: We searched PubMed, Embase, and PsycINFO including randomized clinical trial allocating patients with either schizophrenia or depression to isolated exercise interventions.
   Results: We identified five trials including patients with schizophrenia (n = 94) and found little evidence that exercise could increase cardiovascular fitness or decrease weight. Nine exercise trials for patients with depression (n = 892) were identified increasing cardiovascular fitness by 11-30% and strength by 33-37%. No evidence in favor of exercise for weight reduction was found.
   Conclusion: Based on the current evidence isolated exercise interventions are unlikely to improve cardiovascular fitness or induce weight loss in patients with schizophrenia. In patients with depression, exercise interventions are likely to induce clinically relevant short term effects, however, due to lack of reporting, little is known about the effect on weight reduction and cardiovascular fitness. Future exercise trials regarding patients with mental illness should preferably measure changes in cardiovascular strength, repetition maximum, and anthropometric outcomes. Ideally, participants should be assessed beyond the intervention to identify long lasting effects.
C1 [Krogh, Jesper; Speyer, Helene; Moltke, Ane; Nordentoft, Merete] Univ Copenhagen, Fac Hlth Sci, Mental Hlth Ctr Copenhagen, Copenhagen, Denmark.
   [Krogh, Jesper] Herlev Univ Hosp, Dept Endocrinol, Copenhagen, Denmark.
   [Norgaard, Hans Christian Brix] Aarhus Univ Hosp, Res Unit Dept P, Risskov, Denmark.
   [Moltke, Ane] Univ Roskilde, Res Ctr Hlth Promot, Roskilde, Denmark.
C3 University of Copenhagen; University of Copenhagen; Copenhagen
   University Hospital; Herlev & Gentofte Hospital; Aarhus University;
   Roskilde University
RP Nordentoft, M (corresponding author), Univ Copenhagen, Fac Hlth Sci, Mental Hlth Ctr Copenhagen, Copenhagen, Denmark.; Nordentoft, M (corresponding author), Bispebjerg Bakke 23, Copenhagen, Denmark.
EM mn@dadlnet.dk
RI speyer, helene/KGM-0671-2024; Nordentoft, Merete/AAH-3253-2019; Krogh,
   Jesper/C-6876-2013
OI Krogh, Jesper/0000-0003-4834-6724; Nordentoft,
   Merete/0000-0003-4895-7023; Brix Norgaard, Hans
   Christian/0000-0001-9985-1259
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Battaglia G, 2013, NEUROPSYCH DIS TREAT, V9, P595, DOI 10.2147/NDT.S44066
   Beebe Lora Humphrey, 2005, Issues Ment Health Nurs, V26, P661
   Blumenthal JA, 1999, ARCH INTERN MED, V159, P2349, DOI 10.1001/archinte.159.19.2349
   Blumenthal JA, 2007, PSYCHOSOM MED, V69, P587, DOI 10.1097/PSY.0b013e318148c19a
   Caemmerer J, 2012, SCHIZOPHR RES, V140, P159, DOI 10.1016/j.schres.2012.03.017
   Chalder M, 2012, HEALTH TECHNOL ASSES, V16, P1, DOI 10.3310/hta16100
   Chalder M, 2012, BMJ-BRIT MED J, V344, DOI 10.1136/bmj.e2758
   Daumit GL, 2008, SCHIZOPHR RES, V105, P175, DOI 10.1016/j.schres.2008.07.006
   Daumit GL, 2013, NEW ENGL J MED, V368, P1594, DOI 10.1056/NEJMoa1214530
   Daumit GL, 2005, J NERV MENT DIS, V193, P641, DOI 10.1097/01.nmd.0000180737.85895.60
   Davis MJ, 1999, ANN BEHAV MED, V21, P339, DOI 10.1007/BF02895967
   Johnstone R, 2009, J MENT HEALTH, V18, P523, DOI 10.3109/09638230903111114
   Knubben K, 2007, BRIT J SPORT MED, V41, P29, DOI 10.1136/bjsm.2006.030130
   Kodama S, 2009, JAMA-J AM MED ASSOC, V301, P2024, DOI 10.1001/jama.2009.681
   Krane-Gartiser K, 2011, NORD J PSYCHIAT, V65, P345, DOI 10.3109/08039488.2011.565799
   Krogh J, 2014, MENT HEALTH PHYS ACT, V7, P50, DOI 10.1016/j.mhpa.2014.01.003
   Krogh J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048316
   Krogh J, 2009, J CLIN PSYCHIAT, V70, P790, DOI 10.4088/JCP.08m04241
   Laukkanen JA, 2007, J INTERN MED, V262, P263, DOI 10.1111/j.1365-2796.2007.01807.x
   Laursen TM, 2007, J CLIN PSYCHIAT, V68, P899, DOI 10.4088/JCP.v68n0612
   Laursen TM, 2011, SCHIZOPHR RES, V131, P101, DOI 10.1016/j.schres.2011.06.008
   Laursen TM, 2009, ARCH GEN PSYCHIAT, V66, P713, DOI 10.1001/archgenpsychiatry.2009.61
   MARTINSEN EW, 1985, BRIT MED J, V291, P109, DOI 10.1136/bmj.291.6488.109
   Marzolini S., 2009, MENT HEALTH PHYS ACT, V2, P29, DOI 10.1016/j.mhpa.2008.11.001
   McDevitt J, 2006, J NURS SCHOLARSHIP, V38, P50, DOI 10.1111/j.1547-5069.2006.00077.x
   Myers J, 2002, NEW ENGL J MED, V346, P793, DOI 10.1056/NEJMoa011858
   Nordentoft M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055176
   Scheewe TW, 2013, EUR NEUROPSYCHOPHARM, V23, P675, DOI 10.1016/j.euroneuro.2012.08.008
   Shaw K, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003817.pub3
   Singh NA, 2005, J GERONTOL A-BIOL, V60, P768, DOI 10.1093/gerona/60.6.768
   Singh NA, 1997, J GERONTOL A-BIOL, V52, pM27, DOI 10.1093/gerona/52A.1.M27
   Skrinar GS, 2005, PSYCHIATR REHABIL J, V29, P122, DOI 10.2975/29.2005.122.127
   Strassnig M, 2005, SCHIZOPHR RES, V76, P343, DOI 10.1016/j.schres.2005.03.002
   Thorogood A, 2011, AM J MED, V124, P747, DOI 10.1016/j.amjmed.2011.02.037
   Vissers D, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0056415
NR 36
TC 23
Z9 24
U1 0
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JUL 28
PY 2014
VL 5
AR 89
DI 10.3389/fpsyt.2014.00089
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA V46UD
UT WOS:000209908200001
PM 25120495
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Smith, JD
   Berkel, C
   Jordan, N
   Atkins, DC
   Narayanan, SS
   Gallo, C
   Grimm, KJ
   Dishion, TJ
   Mauricio, AM
   Rudo-Stern, J
   Meachum, MK
   Winslow, E
   Bruening, MM
AF Smith, Justin D.
   Berkel, Cady
   Jordan, Neil
   Atkins, David C.
   Narayanan, Shrikanth S.
   Gallo, Carlos
   Grimm, Kevin J.
   Dishion, Thomas J.
   Mauricio, Anne M.
   Rudo-Stern, Jenna
   Meachum, Mariah K.
   Winslow, Emily
   Bruening, Meg M.
TI An individually tailored family-centered intervention for pediatric
   obesity in primary care: study protocol of a randomized type II hybrid
   effectiveness-implementation trial (Raising Healthy Children study)
SO IMPLEMENTATION SCIENCE
LA English
DT Article
DE Family Check-Up 4 Health; Primary care; Hybrid
   effectiveness-implementation trial; Pediatric obesity; Integrated care;
   Coordinated care
ID BODY-MASS INDEX; CHILDHOOD-OBESITY; CHECK-UP; PHYSICAL-ACTIVITY;
   UNITED-STATES; BEHAVIORAL INTERVENTIONS; INSULIN-RESISTANCE;
   EARLY-ADOLESCENCE; MENTAL-HEALTH; RISK
AB Background: Pediatric obesity is a multi-faceted public health concern that can lead to cardiovascular diseases, cancers, and early mortality. Small changes in diet, physical activity, or BMI can significantly reduce the possibility of developing cardiometabolic risk factors. Family-based behavioral interventions are an underutilized, evidence-based approach that have been found to significantly prevent excess weight gain and obesity in children and adolescents. Poor program availability, low participation rates, and non-adherence are noted barriers to positive outcomes. Effective interventions for pediatric obesity in primary care are hampered by low family functioning, motivation, and adherence to recommendations.
   Methods: This (type II) hybrid effectiveness-implementation randomized trial tests the Family Check-Up 4 Health (FCU4Health) program, which was designed to target health behavior change in children by improving family management practices and parenting skills, with the goal of preventing obesity and excess weight gain. The FCU4Health is assessment driven to tailor services and increase parent motivation. A sample of 350 families with children aged 6 to 12 years who are identified as overweight or obese (BMI >= 85th percentile for age and gender) will be enrolled at three primary care clinics [two Federally Qualified Healthcare Centers (FQHCs) and a children's hospital]. All clinics serve predominantly Medicaid patients and a large ethnic minority population, including Latinos, African Americans, and American Indians who face disparities in obesity, cardiometabolic risk, and access to care. The FCU4Health will be coordinated with usual care, using two different delivery strategies: an embedded approach for the two FQHCs and a referral model for the hospital-based clinic. To assess program effectiveness (BMI, body composition, child health behaviors, parenting, and utilization of support services) and implementation outcomes (such outcomes as acceptability, adoption, feasibility, appropriateness, fidelity, and cost), we use a multi-method and multi-informant assessment strategy including electronic health record data, behavioral observation, questionnaires, interviews, and cost capture methods.
   Discussion: This study has the potential to prevent excess weight gain, obesity, and health disparities in children by establishing the effectiveness of the FCU4Health and collecting information critical for healthcare decision makers to support sustainable implementation of family-based programs in primary care.
C1 [Smith, Justin D.; Jordan, Neil; Gallo, Carlos; Meachum, Mariah K.] Northwestern Univ, Feinberg Sch Med, Dept Psychiat & Behav Sci, Chicago, IL 60611 USA.
   [Smith, Justin D.] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA.
   [Smith, Justin D.] Northwestern Univ, Dept Pediat, Feinberg Sch Med, Chicago, IL 60611 USA.
   [Berkel, Cady; Grimm, Kevin J.; Dishion, Thomas J.; Mauricio, Anne M.; Rudo-Stern, Jenna; Winslow, Emily] Arizona State Univ, Dept Psychol, REACH Inst, Tempe, AZ 85287 USA.
   [Atkins, David C.] Univ Washington, Sch Med, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
   [Narayanan, Shrikanth S.] Univ Southern Calif, Dept Elect Engn & Comp Sci, Los Angeles, CA USA.
   [Bruening, Meg M.] Arizona State Univ, Dept Nutr, Tempe, AZ USA.
C3 Northwestern University; Feinberg School of Medicine; Northwestern
   University; Feinberg School of Medicine; Northwestern University;
   Feinberg School of Medicine; Arizona State University; Arizona State
   University-Tempe; University of Washington; University of Washington
   Seattle; University of Southern California; Arizona State University;
   Arizona State University-Tempe
RP Smith, JD (corresponding author), Northwestern Univ, Feinberg Sch Med, Dept Psychiat & Behav Sci, Chicago, IL 60611 USA.; Smith, JD (corresponding author), Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA.
EM jd.smith@northwestern.edu
RI Rudo-Stern, Jenna/JXY-5835-2024; Mauricio, Anne Marie/LIF-2653-2024;
   Narayanan, Shrikanth/D-5676-2012; Berkel, Cady/A-1372-2010
OI Rudo-Stern, Jenna/0000-0002-6763-6308; Bruening,
   Meg/0000-0002-8301-8040; Atkins, David/0000-0002-5781-9880; Berkel,
   Cady/0000-0001-9664-9485
FU National Center for Chronic Disease Prevention and Health Promotion of
   the Centers of Disease Control and Prevention, under the Childhood
   Obesity Research Demonstration Project 2.0 (CORD) [U18 DP006255];
   National Institute on Drug Abuse [DA027828]; Implementation Research
   Institute (IRI) at the George Warren Brown School of Social Work,
   Washington University in St. Louis, through National Institute of Mental
   Health [R25 MH080916]; Implementation Research Institute (IRI) at the
   George Warren Brown School; College of Liberal Arts and Sciences at the
   Arizona State University
FX This study is supported by grant U18 DP006255 from the National Center
   for Chronic Disease Prevention and Health Promotion of the Centers of
   Disease Control and Prevention, under the Childhood Obesity Research
   Demonstration Project 2.0 (CORD), awarded to Cady Berkel and Justin
   Smith. Additional support was provided by grant DA027828 from the
   National Institute on Drug Abuse, awarded to C. Hendricks Brown, and by
   the Implementation Research Institute (IRI) at the George Warren Brown
   School of Social Work, Washington University in St. Louis, through grant
   R25 MH080916 from the National Institute of Mental Health and the
   Department of Veterans Affairs, Health Services Research and Development
   Service, Quality Enhancement Research Initiative (QUERI). The opinions
   expressed herein are the views of the authors and do not necessarily
   reflect the official policy or position of the Centers for Disease
   Control and Prevention, the Department of Veterans Affairs, the National
   Institute on Drug Abuse, the National Institute of Mental Health, or any
   other part of the US Department of Health and Human Services. The
   development work for this study was supported by a research grant from
   the College of Liberal Arts and Sciences at the Arizona State
   University, awarded to Thomas Dishion.
CR Aiken LS., 1991, Multiple regression: Testing and interpreting interactions
   Altman M, 2015, J CLIN CHILD ADOLESC, V44, P521, DOI 10.1080/15374416.2014.963854
   [Anonymous], STRENGTHENING FAMILI
   Arbuckle JL, 1996, ADV STRUCTURAL EQUAT, V243, P243, DOI DOI 10.4324/9781315827414
   Atkins DC, 2014, IMPLEMENT SCI, V9, DOI 10.1186/1748-5908-9-49
   Atkins DC, 2012, J FAM PSYCHOL, V26, P816, DOI 10.1037/a0029607
   August GP, 2008, J CLIN ENDOCR METAB, V93, P4576, DOI 10.1210/jc.2007-2458
   Austin CA, 2016, PARENT EXPERIENCE AS
   Barlow SE, 2007, PEDIATRICS, V120, pS164, DOI 10.1542/peds.2007-2329C
   Barness LA, 2007, AM J MED GENET A, V143A, P3016, DOI 10.1002/ajmg.a.32035
   Barr-Anderson DJ, 2013, OBES REV, V14, P29, DOI 10.1111/j.1467-789X.2012.01043.x
   Berkel C, 2017, COMMUNITY RESOURCES
   Berkel C, 2011, PREV SCI, V12, P23, DOI 10.1007/s11121-010-0186-1
   Boutelle KN, 2010, HEALTH PSYCHOL, V29, P293, DOI 10.1037/a0018645
   Boyd-Ball AJ, 2003, ALCOHOL CLIN EXP RES, V27, P1356, DOI 10.1097/01.ALC.0000080166.14054.7C
   Boyd-Ball AJ, 2006, ADOLESCENT SUBSTANCE ABUSE: RESEARCH AND CLINICAL ADVANCES, P423, DOI 10.1017/CBO9780511543968.021
   Brewis AA, 2014, SOC SCI MED, V118, P152, DOI 10.1016/j.socscimed.2014.08.003
   BROUSSARD BA, 1991, AM J CLIN NUTR, V53, pS1535, DOI 10.1093/ajcn/53.6.1535S
   Brown CH, 2017, ANNU REV PUBL HEALTH, V38, P1, DOI 10.1146/annurev-publhealth-031816-044215
   Brown CH, 2012, ADM POLICY MENT HLTH, V39, P301, DOI 10.1007/s10488-011-0387-3
   Burgert TS, 2006, J CLIN ENDOCR METAB, V91, P4287, DOI 10.1210/jc.2006-1010
   Burke V, 1998, J PEDIATR-US, V132, P840, DOI 10.1016/S0022-3476(98)70315-4
   Burwell S., 2014, 2014 Annual Report on the Quality of Care for Children in Medicaid and CHIP
   Carnethon MR, 2003, JAMA-J AM MED ASSOC, V290, P3092, DOI 10.1001/jama.290.23.3092
   Centers for Disease Control and Prevention, 2016, CHILDH OB RES DEM 2
   Chambers DA, 2013, IMPLEMENT SCI, V8, DOI 10.1186/1748-5908-8-117
   Chiapa A., 2015, Journal of Consulting and Clinical Psychology
   Chiapa A, 2016, TRANSL BEHAV MED, V6, P90, DOI 10.1007/s13142-015-0375-3
   Cohen J., 1988, STAT POWER ANAL BEHA, DOI [10.4324/9780203771587, DOI 10.4324/9780203771587]
   Collins K.S., 2002, Diverse communities, common concerns: Assessing health care quality for minority Americans
   Connell AM, 2006, MERRILL PALMER QUART, V52, P421, DOI 10.1353/mpq.2006.0025
   Control CfD, 2010, PREV EST HOL FRAM RE
   Criss MA, 2005, J FAM PSYCHOL, V19, P592, DOI 10.1037/0893-3200.19.4.592
   Crosnoe R, 2004, J HEALTH SOC BEHAV, V45, P393, DOI 10.1177/002214650404500403
   Curran GM, 2012, MED CARE, V50, P217, DOI 10.1097/MLR.0b013e3182408812
   Dishion T.J., 2011, Everyday Parenting: A Professional's Guide to Building Family Management Skills
   Dishion TJ, 2008, CHILD DEV, V79, P1395, DOI 10.1111/j.1467-8624.2008.01195.x
   Dishion TJ, 2017, PREV SCI, V18, P268, DOI 10.1007/s11121-016-0697-5
   Dishion TJ, 2014, J ABNORM CHILD PSYCH, V42, P343, DOI 10.1007/s10802-013-9768-2
   DISHION TJ, 1995, J CONSULT CLIN PSYCH, V63, P538, DOI 10.1037/0022-006X.63.4.538
   Drummond MF., 2015, METHODS EC EVALUATIO
   Eaton Danice K., 2012, Morbidity and Mortality Weekly Report, V61, P1
   Echeverría SE, 2014, J ADOLESCENT HEALTH, V55, P402, DOI 10.1016/j.jadohealth.2014.03.012
   Ellis L. K., 2001, BIENN M SOC RES CHIL, DOI [10.1037/t07624-000, DOI 10.1037/T07624-000]
   EPISCenter, 2005, ANN SURV EV BAS PROG
   Freeman, 2013, VITAL HLTH STAT, V10, P1
   Fritz MS, 2007, PSYCHOL SCI, V18, P233, DOI 10.1111/j.1467-9280.2007.01882.x
   Gallo C, 2015, ADM POLICY MENT HLTH, V42, P574, DOI 10.1007/s10488-014-0538-4
   Glasgow RE, 2007, ANNU REV PUBL HEALTH, V28, P413, DOI 10.1146/annurev.publhealth.28.021406.144145
   Gonzales NA, 2012, J CONSULT CLIN PSYCH, V80, P1, DOI 10.1037/a0026063
   Goodman R, 1997, J CHILD PSYCHOL PSYC, V38, P581, DOI 10.1111/j.1469-7610.1997.tb01545.x
   Grossman DC, 2017, JAMA-J AM MED ASSOC, V317, P2417, DOI 10.1001/jama.2017.6803
   Haddix AC., 2003, Prevention Effectiveness-A guide to decision analysis and economic evaluation, VSecond
   Hingle MD, 2010, PREV MED, V51, P103, DOI 10.1016/j.ypmed.2010.04.014
   Hsieh HF, 2005, QUAL HEALTH RES, V15, P1277, DOI 10.1177/1049732305276687
   Imel ZE, 2014, J COUNS PSYCHOL, V61, P146, DOI 10.1037/a0034943
   JURS SG, 1971, J EXP EDUC, V40, P62, DOI 10.1080/00220973.1971.11011304
   Kamath CC, 2008, J CLIN ENDOCR METAB, V93, P4606, DOI 10.1210/jc.2006-2411
   Kelleher KJ, 2006, CURR OPIN PEDIATR, V18, P649, DOI 10.1097/MOP.0b013e3280106a76
   Kim G, 2011, PEDIATR CLIN N AM, V58, P1355, DOI 10.1016/j.pcl.2011.09.002
   Kitzman-Ulrich H, 2010, CLIN CHILD FAM PSYCH, V13, P231, DOI 10.1007/s10567-010-0073-0
   Kitzmann K.M., 2011, Couple and Family Psychology: Research and Practice, V1, P45, DOI [10.1037/2160-4096.1.S.45, DOI 10.1037/2160-4096.1.S.45]
   Kjobli J, 2012, PREV SCI, V13, P616, DOI 10.1007/s11121-012-0289-y
   Kolko DJ, 2014, J CLIN CHILD ADOLESC, V43, P216, DOI 10.1080/15374416.2013.862804
   Konstantopoulos S, 2010, J EXP EDUC, V78, P291, DOI 10.1080/00220970903292876
   Krebs NF, 2003, PEDIATRICS, V112, P424, DOI 10.1542/peds.112.2.424
   Krippendorff K, 2011, COMMUN METHODS MEAS, V5, P93, DOI 10.1080/19312458.2011.568376
   Lee S., 2012, RETURN INVESTMENT EV, DOI DOI 10.1111/j.1360-0443.2008.02274.x
   Leslie LK, 2016, AM J PREV MED, V51, pS106, DOI 10.1016/j.amepre.2016.05.014
   Leslie LK, 2016, AM J PREV MED
   Lloyd-Jones DM, 2010, CIRCULATION, V121, P586, DOI 10.1161/CIRCULATIONAHA.109.192703
   López-Guimerà G, 2012, EAT WEIGHT DISORD-ST, V17, pE210, DOI 10.3275/8245
   Lord SP, 2015, BEHAV THER, V46, P296, DOI 10.1016/j.beth.2014.11.002
   Loudon K, 2015, BMJ-BRIT MED J, V350, DOI 10.1136/bmj.h2147
   Luke DA, 2014, PREV CHRONIC DIS, V11, DOI 10.5888/pcd11.130184
   MCCLELLAND GH, 1993, PSYCHOL BULL, V114, P376, DOI 10.1037/0033-2909.114.2.376
   McEachern AD, 2012, J CHILD FAM STUD, V21, P498, DOI 10.1007/s10826-011-9503-y
   McGovern L, 2008, J CLIN ENDOCR METAB, V93, P4600, DOI 10.1210/jc.2006-2409
   Messiah SE, 2013, OBESITY, V21, P424, DOI 10.1002/oby.20343
   Metzler CW, 1998, J FAM PSYCHOL, V12, P600, DOI 10.1037/0893-3200.12.4.600
   Montano Z, 2014, ANN M SOC PREV RES 2
   Moreno JP, 2011, PEDIAT OBESITY 2, V6
   Muthen, 2014, MPLUS USERS GUIDE VE
   Muthen BO, 1995, SOCIOL METHODOL, V25, P267, DOI 10.2307/271070
   National Cancer Institute DoCCaPS, 2013, APPL RES PROGR SHORT
   National Research Council and Institute of Medicine, 2011, EARL CHILDH OB PREV
   Nguyen T D, 1983, Eval Program Plann, V6, P299, DOI 10.1016/0149-7189(83)90010-1
   Ogden CL, 2016, JAMA-J AM MED ASSOC, V315, P2292, DOI 10.1001/jama.2016.6361
   Olza J, 2012, DIABETES CARE, V35, P2373, DOI 10.2337/dc12-0614
   Palinkas LA, 2011, ADM POLICY MENT HLTH, V38, P44, DOI 10.1007/s10488-010-0314-z
   Peter H., 2000, Multiple Comparisons and Multiple Tests (Text and Workbook Set)
   Prado G, 2015, AM J PREV MED, V48, P488, DOI 10.1016/j.amepre.2014.11.014
   Proctor E, 2011, ADM POLICY MENT HLTH, V38, P65, DOI 10.1007/s10488-010-0319-7
   Proctor EK, 2009, ADM POLICY MENT HLTH, V36, P24, DOI 10.1007/s10488-008-0197-4
   Putnam S.P., 2006, J PERS ASSESS, V87, P103, DOI [10.1207/s15327752jpa870109, 10.1207/s15327752jpa8701_09, DOI 10.1207/S15327752JPA8701_09]
   Raudenbush S., 2011, Optimal design plus empirical evidence (version 3.0)
   REIMERS TM, 1991, CHILD FAM BEHAV THER, V13, P53, DOI 10.1300/J019v13n02_04
   REIMERS TM, 1992, SCHOOL PSYCHOL REV, V21, P628
   Resseguier N, 2011, EPIDEMIOLOGY, V22, P282, DOI 10.1097/EDE.0b013e318209dec7
   Rhee K, 2008, ANN AM ACAD POLIT SS, V615, P12, DOI 10.1177/0002716207308400
   Ritzwoller DP, 2009, ANN BEHAV MED, V37, P218, DOI 10.1007/s12160-009-9088-5
   Sadeh A, 2009, J SLEEP RES, V18, P60, DOI 10.1111/j.1365-2869.2008.00699.x
   Schafer JL, 2002, PSYCHOL METHODS, V7, P147, DOI 10.1037//1082-989X.7.2.147
   Schulz A, 2004, HEALTH EDUC BEHAV, V31, P455, DOI 10.1177/1090198104265598
   Singer JD, 2003, PSYCHOL BULL, V132, P667
   Smith JD, 2016, FAMILY CHECK UP 4 HL
   Smith JD, 2016, PREV SCI
   Smith JD, 2016, PREV SCI, V17, P62, DOI 10.1007/s11121-015-0589-0
   Smith JD, 2015, ADM POLICY MENT HLTH, V42, P265, DOI 10.1007/s10488-014-0566-0
   Smith JD, 2015, PREV SCI, V16, P408, DOI 10.1007/s11121-014-0505-z
   Smith JD, 2014, J CLIN CHILD ADOLESC, V43, P400, DOI 10.1080/15374416.2014.888670
   Smith JD, 2013, J CONSULT CLIN PSYCH, V81, P962, DOI 10.1037/a0033950
   Stiles PG, 2002, J BEHAV HEALTH SER R, V29, P198, DOI 10.1007/BF02287706
   Stormshak EA, 2011, CHILD DEV, V82, P209, DOI 10.1111/j.1467-8624.2010.01551.x
   Sung-Chan P, 2013, OBES REV, V14, P265, DOI 10.1111/obr.12000
   Taylor AB, 2008, ORGAN RES METHODS, V11, P241, DOI 10.1177/1094428107300344
   Truby H, 2002, BRIT J CLIN PSYCHOL, V41, P185, DOI 10.1348/014466502163967
   Turner KM, 2009, BRIT J GEN PRACT, V59, P856, DOI 10.3399/bjgp09X472269
   Van Ryzin MJ, 2013, J FAM PSYCHOL, V27, P106, DOI 10.1037/a0031428
   Varni JW, 2001, MED CARE, V39, P800, DOI 10.1097/00005650-200108000-00006
   Wacker D.P., 2005, EDUC PSYCHOL-UK, V25, P233, DOI [DOI 10.1080/0144341042000301184, 10.1080/0144341042000301184]
   Walton K, 2014, BMC PEDIATR, V14, DOI 10.1186/1471-2431-14-244
   Wang DD, 2016, IMPLEMENT SCI, V11, DOI 10.1186/s13012-016-0483-6
   Wang Y, 2007, EPIDEMIOL REV, V29, P6, DOI 10.1093/epirev/mxm007
   Ware JH, 2011, NEW ENGL J MED, V364, P1685, DOI 10.1056/NEJMp1103502
   Whitlock EP, 2010, PEDIATRICS, V125, pE396, DOI 10.1542/peds.2009-1955
   Widaman K.F., 1997, SCI PREVENTION, P281, DOI DOI 10.1037/10222-009
   Wilfley DE, 2007, HEALTH PSYCHOL, V26, P521, DOI 10.1037/0278-6133.26.5.521
   Winter C., 2007, Parent consultant log
   Xiao B, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0143055
   Young KM, 2007, CLIN PSYCHOL REV, V27, P240, DOI 10.1016/j.cpr.2006.08.003
NR 131
TC 41
Z9 45
U1 4
U2 38
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1748-5908
J9 IMPLEMENT SCI
JI Implement. Sci.
PD JAN 15
PY 2018
VL 13
AR 11
DI 10.1186/s13012-017-0697-2
PG 15
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA FS6JE
UT WOS:000419902900001
PM 29334983
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ibrahim, HA
   El-Meligi, AA
   Abdel-Hamid, M
   Elhendy, A
AF Ibrahim, HA
   El-Meligi, AA
   Abdel-Hamid, M
   Elhendy, A
TI Relations between von Willebrand factor, markers of oxidative stress and
   microalbuminuria in patients with type 2 diabetes mellitus
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE diabetes mellitus; oxidative stress; microalbuminurea; von Willebrand
   factor; coronary artery disease
ID INSULIN-RESISTANCE SYNDROME; INCREASED PLASMA-LEVELS; ENDOTHELIAL
   DYSFUNCTION; ALBUMIN EXCRETION; NIDDM PATIENTS; VITAMIN-C; DISEASE;
   RISK; MECHANISMS; MORTALITY
AB Background: To assess the relations among plasma levels of von Willebrand factor (vWf), microalbuminuria and markers of oxidative stress in patients with type 2 diabetes mellitus.
   Material/Methods: We studied 10 healthy subjects without microalbuminuria or history of coronary artery disease (CAD) and 30 patients with type 2 diabetes mellitus who were classified into three groups, each including 10 patients of matched age and sex; group 1: patients without microalbuminuria or history of CAD; group 2: patients with microalbuminuria and no history of CAD, and group 3: patients with microalbuminuria and history of CAD. All subjects underwent laboratory measurements of vWf, albumin excretion rate (AER), malondialdehyde, vitamin C, reduced glutathione and C peptide.
   Results: vWf was elevated in patients with type 2 diabetes mellitus compared with control subjects. However, levels were higher in patients with than without microalbuminuria and in patients with than without a history of CAD (96 +/- 12, 124 +/- 7, 149 +/- 9, 175 +/- 7 in the control subjects and the diabetic patients' groups respectively). There was a positive correlation between vWf and AER, MDA and C- peptide (r = 0.91, 0.98, 0.96, p < 0.0001) and a negative correlation between vWf and both vitamin C and reduced glutathione (r = -0.59 and -0.62 respectively, p < 0.001).
   Conclusions: vWf levels are elevated in patients with type 2 diabetes mellitus, particularly in the presence of microalbuminuria and history of CAD. vWf levels are associated with markers of increased oxidative stress and therefore reflect the severity of biochemical abnormalities, which contribute to diabetic vascular disease.
C1 Univ Nebraska, Med Ctr, Dept Internal Med, Omaha, NE 68198 USA.
   Cairo Univ Hosp, Dept Internal Med, Cairo, Egypt.
   Cairo Univ Hosp, Dept Cardiol, Cairo, Egypt.
C3 University of Nebraska System; University of Nebraska Medical Center;
   Egyptian Knowledge Bank (EKB); Cairo University; Cairo University
   Hospital; Egyptian Knowledge Bank (EKB); Cairo University; Cairo
   University Hospital
RP Univ Nebraska, Med Ctr, Dept Internal Med, 982055, Omaha, NE 68198 USA.
EM aelhendy@unmc.edu
RI ElMeligi, Dr Amin/LMP-0828-2024
CR BEUTLER E, 1984, RED CELL METABOLISM, V835, P105
   Bressler P, 1996, DIABETOLOGIA, V39, P1345, DOI 10.1007/s001250050581
   COLLIER A, 1992, DIABETES, V41, P909, DOI 10.2337/diabetes.41.8.909
   Dominguez C, 1998, DIABETES CARE, V21, P1736, DOI 10.2337/diacare.21.10.1736
   Feng DL, 2000, DIABETES CARE, V23, P1694, DOI 10.2337/diacare.23.11.1694
   FREI B, 1994, AM J MED, V97, pS5, DOI 10.1016/0002-9343(94)90292-5
   Gæde P, 2001, NEPHROL DIAL TRANSPL, V16, P2028, DOI 10.1093/ndt/16.10.2028
   GILBERT RE, 1994, DIABETIC MED, V11, P636, DOI 10.1111/j.1464-5491.1994.tb00325.x
   Greaves M, 1997, DIABETOLOGIA, V40, P698, DOI 10.1007/s001250050736
   Ha H, 1999, DIABETES RES CLIN PR, V45, P147, DOI 10.1016/S0168-8227(99)00044-3
   Hink U, 2001, CIRC RES, V88, pE14
   IWATA J, 1979, CLIN CHEM, V25, P1317
   JAGOTA SK, 1982, ANAL BIOCHEM, V127, P178, DOI 10.1016/0003-2697(82)90162-2
   Kessler L, 1998, DIABETES METAB, V24, P327
   Kim YI, 2001, DIABETES RES CLIN PR, V52, P145, DOI 10.1016/S0168-8227(01)00228-5
   KONKLE BA, 1995, CLIN CHEM, V41, P489
   MORISE T, 1995, DIABETES CARE, V18, P87, DOI 10.2337/diacare.18.1.87
   Pinkney JH, 1997, DIABETES, V46, pS9, DOI 10.2337/diab.46.2.S9
   SATOH K, 1978, CLIN CHIM ACTA, V90, P37
   Schiekofer S, 2000, SEMIN THROMB HEMOST, V26, P503, DOI 10.1055/s-2000-13206
   Seligman BGS, 2000, DIABETES CARE, V23, P1395, DOI 10.2337/diacare.23.9.1395
   SINCLAIR AJ, 1994, DIABETIC MED, V11, P893, DOI 10.1111/j.1464-5491.1994.tb00375.x
   Slatter DA, 2000, DIABETOLOGIA, V43, P550, DOI 10.1007/s001250051342
   Spoelstra-De Man AME, 2001, DIABETES CARE, V24, P2097, DOI 10.2337/diacare.24.12.2097
   TESFAMARIAM B, 1992, AM J PHYSIOL, V263, pH321, DOI 10.1152/ajpheart.1992.263.2.H321
   Valmadrid CT, 2000, ARCH INTERN MED, V160, P1093, DOI 10.1001/archinte.160.8.1093
   Vijayalingam S, 1996, DIABETIC MED, V13, P715, DOI 10.1002/(SICI)1096-9136(199608)13:8<715::AID-DIA172>3.0.CO;2-Z
   Vischer UM, 1998, THROMB HAEMOSTASIS, V80, P1002
   YOSHIDA K, 1995, DIABETOLOGIA, V38, P201, DOI 10.1007/BF00400095
NR 29
TC 18
Z9 19
U1 0
U2 0
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD MAR
PY 2004
VL 10
IS 3
BP CR85
EP CR89
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 867HC
UT WOS:000224832100006
PM 14976459
DA 2025-06-11
ER

PT J
AU Panting, JR
   Gatehouse, PD
   Yang, GZ
   Grothues, F
   Firmin, DN
   Collins, P
   Pennell, DJ
AF Panting, JR
   Gatehouse, PD
   Yang, GZ
   Grothues, F
   Firmin, DN
   Collins, P
   Pennell, DJ
TI Abnormal subendocardial perfusion in cardiac syndrome X detected by
   cardiovascular magnetic resonance imaging
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Article
ID NORMAL CORONARY ARTERIOGRAMS; LEFT-VENTRICULAR FUNCTION; MYOCARDIAL
   BLOOD-FLOW; ANGINA-PECTORIS; CHEST-PAIN; ARTERY-DISEASE; VASODILATOR
   RESERVE; LACTATE PRODUCTION; ISCHEMIA; DYSFUNCTION
AB Background: In cardiac syndrome X (a syndrome characterized by typical angina, abnormal exercise-test results, and normal coronary arteries), conventional investigations have not found that chest pain is due to myocardial ischemia. Magnetic resonance techniques have higher resolution and therefore may be more sensitive.
   Methods: We performed myocardial-perfusion cardiovascular magnetic resonance imaging in 20 patients with syndrome X and 10 matched controls, both at rest and during an infusion of adenosine. Quantitative perfusion analysis was performed by using the normalized upslope of myocardial signal enhancement to derive the myocardial perfusion index and the myocardial-perfusion reserve index (defined as the ratio of the myocardial perfusion index during stress to the index at rest).
   Results: In the controls, the myocardial perfusion index increased in both myocardial layers with adenosine (in the subendocardium, from a mean [+/-SD] of 0.12+/-0.03 to 0.16+/-0.03 [P=0.02]; in the subepicardium, from 0.11+/-0.02 to 0.17+/-0.05 [P=0.002]); in patients with syndrome X, the myocardial perfusion index did not change significantly in the subendocardium (0.13+/-0.02 vs. 0.14+/-0.03, P=0.11; P=0.09 as compared with controls) but increased in the subepicardium (from 0.11+/-0.02 to 0.20+/-0.04, P<0.001; P=0.11 for the comparison with controls). Adenosine provoked chest pain in 95 percent of patients with syndrome X and 40 percent of controls (P<0.001).
   Conclusions: In patients with syndrome X, cardiovascular magnetic resonance imaging demonstrates subendocardial hypoperfusion during the intravenous administration of adenosine, which is associated with intense chest pain. These data support the notion that the chest pain may have an ischemic cause.
C1 Royal Brompton Hosp, Cardiovasc Magnet Resonance Unit, London SW3 6NP, England.
   Royal Brompton Hosp, Dept Cardiovasc Med, London SW3 6NP, England.
   Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England.
   Univ London Imperial Coll Sci Technol & Med, Dept Comp, London, England.
C3 Royal Brompton Hospital; Royal Brompton Hospital; Imperial College
   London; Imperial College London
RP Royal Brompton Hosp, Cardiovasc Magnet Resonance Unit, Sydney St, London SW3 6NP, England.
OI Pennell, Dudley/0000-0001-5523-1314; Firmin, David/0000-0003-3894-7489;
   Gatehouse, Peter/0000-0002-0260-4719
CR Al-Saadi N, 2000, CIRCULATION, V101, P1379, DOI 10.1161/01.CIR.101.12.1379
   ARBOGAST R, 1973, AM J CARDIOL, V32, P257, DOI 10.1016/S0002-9149(73)80130-4
   Bellamy MF, 1998, CARDIOVASC RES, V40, P410, DOI 10.1016/S0008-6363(98)00184-9
   BOUDOULAS H, 1974, AM J CARDIOL, V34, P501, DOI 10.1016/0002-9149(74)90118-0
   Buchthal SD, 2000, NEW ENGL J MED, V342, P829, DOI 10.1056/NEJM200003233421201
   Buffon A, 2000, AM J PHYSIOL-HEART C, V279, pH2627, DOI 10.1152/ajpheart.2000.279.6.H2627
   CAMICI PG, 1992, CIRCULATION, V86, P179, DOI 10.1161/01.CIR.86.1.179
   CAMICI PG, 1991, J AM COLL CARDIOL, V17, P1461, DOI 10.1016/0735-1097(91)90632-J
   CANNON RO, 1985, CIRCULATION, V71, P218, DOI 10.1161/01.CIR.71.2.218
   CANNON RO, 1983, J AM COLL CARDIOL, V1, P1359, DOI 10.1016/S0735-1097(83)80037-0
   CANNON RO, 1988, AM J CARDIOL, V61, P1338, DOI 10.1016/0002-9149(88)91180-0
   CANTY JM, 1985, CIRCULATION, V71, P370, DOI 10.1161/01.CIR.71.2.370
   Cullen JHS, 1999, J AM COLL CARDIOL, V33, P1386, DOI 10.1016/S0735-1097(99)00004-2
   EMDIN M, 1989, J AM COLL CARDIOL, V14, P1450, DOI 10.1016/0735-1097(89)90380-X
   GALASSI AR, 1993, AM J CARDIOL, V72, P134, DOI 10.1016/0002-9149(93)90148-6
   GREENBERG MA, 1987, J AM COLL CARDIOL, V9, P743, DOI 10.1016/S0735-1097(87)80227-9
   KASKI JC, 1995, J AM COLL CARDIOL, V25, P807, DOI 10.1016/0735-1097(94)00507-M
   KASKI JC, 1991, J AM COLL CARDIOL, V18, P50, DOI 10.1016/S0735-1097(10)80216-5
   Keijer JT, 2000, J CARDIOV MAGN RESON, V2, P189, DOI 10.3109/10976640009146567
   KEMP HG, 1986, J AM COLL CARDIOL, V7, P479, DOI 10.1016/S0735-1097(86)80456-9
   KEMP HG, 1973, AM J CARDIOL, V32, P375, DOI 10.1016/S0002-9149(73)80150-X
   Lanza GA, 1997, CIRCULATION, V96, P821
   Lauerma K, 1997, CIRCULATION, V96, P2859, DOI 10.1161/01.CIR.96.9.2859
   LEGRAND V, 1985, J AM COLL CARDIOL, V6, P1245, DOI 10.1016/S0735-1097(85)80209-6
   MASERI A, 1991, J AM COLL CARDIOL, V17, P499, DOI 10.1016/S0735-1097(10)80122-6
   Meeder JG, 1995, EUR HEART J, V16, P1571, DOI 10.1093/oxfordjournals.eurheartj.a060780
   NIHOYANNOPOULOS P, 1991, J AM COLL CARDIOL, V18, P1463, DOI 10.1016/0735-1097(91)90676-Z
   OPHERK D, 1981, CIRCULATION, V63, P817, DOI 10.1161/01.CIR.63.4.817
   OPHERK D, 1989, CIRCULATION, V80, P1610, DOI 10.1161/01.CIR.80.6.1610
   ROSEN SD, 1994, CIRCULATION, V90, P50, DOI 10.1161/01.CIR.90.1.50
   Schwitter J, 2001, CIRCULATION, V103, P2230
   TWEDDEL AC, 1992, BRIT HEART J, V68, P48
   WILKE N, 1993, MAGNET RESON MED, V29, P485, DOI 10.1002/mrm.1910290410
   Wood D, 1998, HEART, V80, pS1
NR 34
TC 569
Z9 603
U1 1
U2 11
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
EI 1533-4406
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD JUN 20
PY 2002
VL 346
IS 25
BP 1948
EP 1953
DI 10.1056/NEJMoa012369
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 563QC
UT WOS:000176266200003
PM 12075055
OA Bronze
DA 2025-06-11
ER

PT J
AU Chirinos, DA
   Kershaw, KN
   Allen, NB
   Carroll, AJ
   Lewis, TT
   Schreiner, PJ
   Lewis, CE
   Kiefe, CI
   Mezuk, B
   Carnethon, MR
AF Chirinos, Diana A.
   Kershaw, Kiarri N.
   Allen, Norrina B.
   Carroll, Allison J.
   Lewis, Tene T.
   Schreiner, Pamela J.
   Lewis, Cora E.
   Kiefe, Catarina I.
   Mezuk, Briana
   Carnethon, Mercedes R.
TI Depressive Symptom Subgroups and Their Association with Prevalent and
   Incident Cardiovascular Risk Factors in the Coronary Artery Risk
   Development in Young Adults (CARDIA) Study
SO INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Depression; Cardiovascular risk factors; Obesity; Diabetes;
   Hypertension; Cardiovascular disease
ID RANDOMIZED CONTROLLED-TRIAL; PROBLEM-SOLVING THERAPY; WEIGHT-LOSS
   TREATMENT; METABOLIC SYNDROME; COMORBID OBESITY; POSITIVE AFFECT;
   OLDER-ADULTS; ANXIETY; HYPERTENSION; WOMEN
AB Background We sought to identify depressive symptom subgroups in a community sample of young adults, investigate their stability over time, and determine their association with prevalent and incident cardiovascular disease (CVD) risk factors. Method Participants were 3377 adults from the Coronary Artery Risk Development in Young Adults study. Using latent class and latent transition analysis, we derived subgroups based on items of the 20-item version of the Center for Epidemiologic Studies Depression Scale in 1990, and examined patterns of change over a 10-year period (1990-2000). Cox regression models were used to examine associations between subgroup membership and prevalent (2000) and incident (2000 to 2016) obesity, hypertension, and diabetes. Results Three baseline subgroups were identified and labeled: "No Symptoms" (63.5%), "Lack of Positive Affect" (PA, 25.6%), and "Depressed Mood" (10.9%). At 10-year follow-up, individuals in "No Symptoms" subgroup had the highest probability (0.84) of being classified within the same subgroup. Participants classified as "Lack of PA" were likely (0.46) to remain in the same subgroup or be classified as "No Symptoms." Participants in the "Depressed Mood" were most likely to transition to the "Lack of PA" subgroup (0.38). Overall, 30.5% of participants transitioned between subgroups, with 11.4% classified as "Worsening" and 19.1% as "Improving." Relative to the "No Symptoms Stable," other subgroups ("Depressed Stable," "Worsening," and "Improving") were associated with prevalent obesity and hypertension. Conclusion We identified distinct depressive symptom subgroups that are variably stable over time, and their change patterns were differentially associated with CVD risk factor prevalence.
C1 [Chirinos, Diana A.; Kershaw, Kiarri N.; Allen, Norrina B.; Carnethon, Mercedes R.] Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, 680 N Lakeshore Dr,Suite 1400, Chicago, IL 60611 USA.
   [Carroll, Allison J.] Northwestern Univ, Dept Cardiac Surg, Feinberg Sch Med, Chicago, IL USA.
   [Lewis, Tene T.] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA USA.
   [Schreiner, Pamela J.] Univ Minnesota, Div Epidemiol & Community Hlth, Minneapolis, MN USA.
   [Lewis, Cora E.] Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL USA.
   [Kiefe, Catarina I.] Univ Massachusetts, Dept Populat & Quantitat Hlth Sci, Med Sch, Worcester, MA USA.
   [Mezuk, Briana] Univ Michigan, Dept Epidemiol, Ann Arbor, MI USA.
C3 Northwestern University; Feinberg School of Medicine; Northwestern
   University; Feinberg School of Medicine; Emory University; Rollins
   School Public Health; University of Minnesota System; University of
   Minnesota Twin Cities; University of Alabama System; University of
   Alabama Birmingham; University of Massachusetts System; University of
   Massachusetts Worcester; University of Michigan System; University of
   Michigan
RP Chirinos, DA (corresponding author), Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, 680 N Lakeshore Dr,Suite 1400, Chicago, IL 60611 USA.
EM diana.chirinos@northwestern.edu
RI Lewis, Tene/JBS-7332-2023; Mezuk, Briana/AAY-5321-2020; Carroll,
   Allison/JOK-2424-2023
OI Schreiner, Pamela/0000-0002-9920-6257
FU National Heart, Lung, and Blood Institute (NHLBI) [HHSN268201800003I,
   HHSN268201800004I, HHSN268201800005I, HHSN268201800006I,
   HHSN268201800007I]; NHLBI [1K01HL149987-01A1]
FX The Coronary Artery Risk Development in Young Adults Study (CARDIA) is
   supported by contracts HHSN268201800003I, HHSN268201800004I,
   HHSN268201800005I, HHSN268201800006I, and HHSN268201800007I from the
   National Heart, Lung, and Blood Institute (NHLBI). DC is supported by
   1K01HL149987-01A1 from the NHLBI.
CR Association AP, 2013, Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
   Björntorp P, 1999, ANN NY ACAD SCI, V892, P297, DOI 10.1111/j.1749-6632.1999.tb07803.x
   Boehm JK, 2020, PREV MED, V136, DOI 10.1016/j.ypmed.2020.106103
   Brummett BH, 2003, AM J CARDIOL, V92, P529, DOI 10.1016/S0002-9149(03)00719-7
   Burkhauser RV, 2008, J HEALTH ECON, V27, P519, DOI 10.1016/j.jhealeco.2007.05.005
   Carney RM, 2000, PSYCHOSOM MED, V62, P84, DOI 10.1097/00006842-200001000-00013
   Carney RM, 2017, NAT REV CARDIOL, V14, DOI 10.1038/nrcardio.2016.181
   Carney RM, 2012, CURR PSYCHIAT REP, V14, P1, DOI 10.1007/s11920-011-0247-6
   Carney RM, 2012, PSYCHOSOM MED, V74, P33, DOI 10.1097/PSY.0b013e3182405ac4
   Chen LS, 2000, J AFFECT DISORDERS, V59, P1, DOI 10.1016/S0165-0327(99)00132-9
   Chirinos DA, 2017, PSYCHONEUROENDOCRINO, V82, P17, DOI 10.1016/j.psyneuen.2017.04.011
   Chirinos DA, 2013, ANN BEHAV MED, V46, P31, DOI 10.1007/s12160-013-9479-5
   Ciechanowski P, 2004, JAMA-J AM MED ASSOC, V291, P1569, DOI 10.1001/jama.291.13.1569
   Collins L.M., 2013, Latent class and latent transition analysis: With applications in the social, behavioral, and health sciences, DOI [10.1002/9780470567333, DOI 10.1002/9780470567333]
   Davidson K, 2000, ARCH INTERN MED, V160, P1495, DOI 10.1001/archinte.160.10.1495
   Dozois DJA, 1998, PSYCHOL ASSESSMENT, V10, P83, DOI 10.1037/1040-3590.10.2.83
   Everson SA, 2002, J PSYCHOSOM RES, V53, P891, DOI 10.1016/S0022-3999(02)00303-3
   Freak-Poli R, 2015, PREV MED, V74, P14, DOI 10.1016/j.ypmed.2015.01.032
   FRIEDMAN GD, 1988, J CLIN EPIDEMIOL, V41, P1105, DOI 10.1016/0895-4356(88)90080-7
   Gallo JJ, 1997, J AM GERIATR SOC, V45, P570, DOI 10.1111/j.1532-5415.1997.tb03089.x
   Gallo JJ, 1999, AM FAM PHYSICIAN, V60, P820
   Gallo JJ, 1999, PSYCHOL MED, V29, P341, DOI 10.1017/S0033291798008083
   Garbarski D, 2015, ADV LIFE COURSE RES, V23, P67, DOI 10.1016/j.alcr.2014.12.006
   Hasin DS, 2018, JAMA PSYCHIAT, V75, P336, DOI 10.1001/jamapsychiatry.2017.4602
   HUGHES GH, 1987, CONTROL CLIN TRIALS, V8, pS68
   Jacobs David R Jr, 1989, J Cardiopulm Rehabil, V9, P448, DOI 10.1097/00008483-198911000-00003
   Kendler KS, 1996, ARCH GEN PSYCHIAT, V53, P391
   Landau S, 2016, PSYCHOL MED, V46, P657, DOI 10.1017/S0033291715002196
   Linde JA, 2011, ANN BEHAV MED, V41, P119, DOI 10.1007/s12160-010-9232-2
   Lohman MC, 2017, AGING MENT HEALTH, V21, P399, DOI 10.1080/13607863.2015.1102199
   Lorenz MW, 2007, CIRCULATION, V115, P459, DOI 10.1161/CIRCULATIONAHA.106.628875
   Luppino FS, 2011, PSYCHOSOM MED, V73, P257, DOI 10.1097/PSY.0b013e31820a59c0
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Ma J, 2019, JAMA-J AM MED ASSOC, V321, P869, DOI 10.1001/jama.2019.0557
   Marijnissen RM, 2011, J AM GERIATR SOC, V59, P67, DOI 10.1111/j.1532-5415.2010.03228.x
   Mezuk B, 2012, PSYCHOL MED, V42, P2037, DOI 10.1017/S003329171200027X
   Mezuk B, 2013, HEALTH PSYCHOL, V32, P254, DOI 10.1037/a0029014
   Ni YH, 2017, J AFFECT DISORDERS, V209, P3, DOI 10.1016/j.jad.2016.11.004
   Nouwen A, 2011, DIABETES CARE, V34, P752, DOI 10.2337/dc10-1414
   OVERALL JE, 1966, J AMER MED ASSOC, V195, P946, DOI 10.1001/jama.195.11.946
   Pagoto S, 2013, INT J OBESITY, V37, P1427, DOI 10.1038/ijo.2013.25
   Pan Y, 2015, NEUROPSYCH DIS TREAT, V11, P1121, DOI 10.2147/NDT.S77710
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Räikkönen K, 2001, HYPERTENSION, V38, P798, DOI 10.1161/hyp.38.4.798
   Räikkönen K, 2007, DIABETES CARE, V30, P872, DOI 10.2337/dc06-1857
   Rodgers S, 2014, EUR ARCH PSY CLIN N, V264, P577, DOI 10.1007/s00406-013-0475-3
   Steptoe A, 2005, P NATL ACAD SCI USA, V102, P6508, DOI 10.1073/pnas.0409174102
   Steptoe A, 2003, PSYCHOL MED, V33, P667, DOI 10.1017/S0033291702007250
   Strike PC, 2004, PROG CARDIOVASC DIS, V46, P337, DOI 10.1016/j.pcad.2003.09.001
   Ulbricht CM, 2018, AM J MENS HEALTH, V12, P5, DOI 10.1177/1557988315607297
   Ulbricht CM, 2016, ARCH WOMEN MENT HLTH, V19, P769, DOI 10.1007/s00737-016-0606-8
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
   Van der Kooy K, 2007, INT J GERIATR PSYCH, V22, P613, DOI 10.1002/gps.1723
   Wiehe M, 2006, J HUM HYPERTENS, V20, P434, DOI 10.1038/sj.jhh.1002017
   Yasunari K, 2006, AM J HYPERTENS, V19, P573, DOI 10.1016/j.amjhyper.2005.10.027
   Zhang AA, 2018, J AM BOARD FAM MED, V31, P139, DOI 10.3122/jabfm.2018.01.170270
NR 56
TC 4
Z9 4
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1070-5503
EI 1532-7558
J9 INT J BEHAV MED
JI Int. J. Behav. Med.
PD DEC
PY 2023
VL 30
IS 6
BP 891
EP 903
DI 10.1007/s12529-022-10144-z
EA JAN 2023
PG 13
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA AZ2S3
UT WOS:000917920500001
PM 36670342
DA 2025-06-11
ER

PT J
AU Demirci, OO
   Fistikci, N
   Sagaltici, E
   Karamustafalioglu, N
   Yildirim, A
   Ilnem, MC
AF Demirci, Onur Okan
   Fistikci, Nurhan
   Sagaltici, Eser
   Karamustafalioglu, Nesrin
   Yildirim, Abdullah
   Ilnem, Mehmet Cem
TI Metabolic parameters in patients with major depression treated with
   escitalopram
SO ANADOLU PSIKIYATRI DERGISI-ANATOLIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE major depression; metabolic syndrome; metabolic parameters; selective
   serotonin reuptake inhibitors; escitalopram
ID ANTIDEPRESSANT MEDICATION USE; WEIGHT-GAIN; BODY-WEIGHT; RISK
AB Objective: The aim of this study is to determine the change in metabolic parameters of patients with major depression treated with escitalopram. Methods: The height, body weight, waist circumference, blood pressure, lipid profile (total cholesterol, low density lipoprotein [LDL], high density lipoprotein [HDL], triglycerides [TG]), fasting blood glucose (FBG), thyroid stimulating hormone (TSH) and Hamilton Depression Scale (HamD) of 41 consecutively selected patients with major depression were measured before treatment and in the third month of treatment, for whom a decision to start treatment with escitalopram was decided. The relationship between treatment and changes in these metabolic parameters were evaluated at the end of this period. Results: The mean age of patients was 30.24 +/- 9.96 (18-62) years. Eleven (27%) patients were male and 30 (73%) were female. Twelve (29.3%) patients were treated with 10 mg/day escitalopram, and 29 patients (70.7%) 20 mg/day. Significant increases were detected in body weight, body mass index, waist circumference and systolic blood pressures of all patients from initiation of treatment to three months. A significant increase was found in the waist circumference of male patients (n= 11) after three months of treatment. Body weight, body mass index, waist circumference, triglycerides, systolic blood pressure were found to be significantly increased after three months of treatment in female patients (n= 30) who were treated with escitalopram. HamD scores were found to be significantly decreased after three months in patients treated with escitalopram. Conclusion: Escitalopram caused an increase in especially body weight and waist circumference in patients with major depression.
C1 [Demirci, Onur Okan] Tatvan State Hosp, Tatvan, Bitlis, Turkey.
   [Fistikci, Nurhan; Karamustafalioglu, Nesrin; Ilnem, Mehmet Cem] Bakirkoy Res & Training Hosp Psychiat Neurol & Ne, Dept Psychiat, Istanbul, Turkey.
   [Sagaltici, Eser] Bitlis State Hosp, Bitlis, Turkey.
   [Yildirim, Abdullah] Van Yuzuncu Yil Univ, Med Ctr, Dept Psychiat, Van, Turkey.
C3 Tatvan State Hospital; Istanbul Bakirkoy Mental Health & Neurology
   Training & Research Hospital; Bitlis State Hospital; Yuzuncu Yil
   University
RP Demirci, OO (corresponding author), Tatvan Devlet Hastanesi, Psikiyatri Poliklin, Tatvan Bitlis, Turkey.
EM oo_demirci@yahoo.com
RI Yıldırım, Abdullah/C-4921-2019; ilnem, mehmet/AAL-1920-2020; Demirci,
   Onur/V-4438-2017; Sağaltıcı, Eser/AAT-3056-2020
OI Ilnem, Mehmet Cem/0000-0003-1614-9056; Sagaltici,
   Eser/0000-0002-4217-2658
CR Akdemir A., 1996, Journal of Psychiatry Psychology Psychopharmacology, V4, P251
   [Anonymous], 1997, USERS GUIDE STRUCTUR
   [Anonymous], ILAC TEDAVI DERGISI
   Beyazyüz M, 2013, PSYCHIAT INVEST, V10, P148, DOI 10.4306/pi.2013.10.2.148
   Hamer M, 2011, EUR HEART J, V32, P437, DOI 10.1093/eurheartj/ehq438
   Himmerich H, 2004, J PSYCHIAT RES, V38, P485, DOI 10.1016/j.jpsychires.2004.02.002
   Kivimaki M, 2010, DIABETES CARE, V33, P2611, DOI 10.2337/dc10-1187
   Pan A, 2012, INT J OBESITY, V36, P595, DOI 10.1038/ijo.2011.111
   Peh ALH, 2013, ASIAN J PSYCHIATR, V6, P256, DOI 10.1016/j.ajp.2012.12.009
   Price DW, 2013, DIABETES CARE, V36, P216, DOI 10.2337/dc12-0293
   Raeder MB, 2006, J CLIN PSYCHIAT, V67, P1974, DOI 10.4088/JCP.v67n1219
   Serretti A, 2010, J CLIN PSYCHIAT, V71, P1259, DOI 10.4088/JCP.09r05346blu
   Stahl S.M, 2013, Stahl's Essential Psychopharmacology
   Sutin AR, 2012, PSYCHOL MED, V42, P2351, DOI 10.1017/S0033291712000566
   Uher R, 2011, INT J NEUROPSYCHOPH, V14, P367, DOI 10.1017/S1461145710000933
   Vogelzangs N, 2014, NEUROPSYCHOPHARMACOL, V39, P1624, DOI 10.1038/npp.2014.9
   Ye Z, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0021551
   Zimmermann U, 2003, J PSYCHIATR RES, V37, P193, DOI 10.1016/S0022-3956(03)00018-9
NR 18
TC 1
Z9 2
U1 0
U2 7
PU CUMHURIYET UNIV TIP FAK PSIKIYATRI ANABILIM DALI
PI SIVAS
PA CUMHURIYET UNIV TIP FAK PSIKIYATRI ABD, SIVAS, 58140, TURKEY
SN 1302-6631
J9 ANADOLU PSIKIYATR DE
JI Anadolu Psikiyatr. Derg.
PD DEC
PY 2016
VL 17
IS 6
BP 482
EP 488
DI 10.5455/apd.214058
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA EH2AC
UT WOS:000391568600008
DA 2025-06-11
ER

PT J
AU Oxenkrug, G
AF Oxenkrug, Gregory
TI Interferon-gamma - Inducible Inflammation: Contribution to Aging and
   Aging-Associated Psychiatric Disorders
SO AGING AND DISEASE
LA English
DT Review
DE Interferon-gamma; Aging; Inflammation; Neopterin; Kynurenines;
   Depression; Insulin resistance; Obesity; Metabolic syndrome
ID INDOLEAMINE 2,3-DIOXYGENASE ACTIVITY; SINGLE NUCLEOTIDE POLYMORPHISM;
   N-ACETYLSEROTONIN; TRYPTOPHAN-METABOLISM; DEPRESSIVE DISORDER;
   KYNURENINE PATHWAY; CIRCADIAN-RHYTHMS; IMMUNE ACTIVATION;
   GENE-EXPRESSION; MESSENGER-RNA
AB Aging is associated with the chronic, low grade, Th-1 type inflammation. The key Th-1 type, pro-inflammatory cytokine, interferon-gamma (IFNG), transcriptionally induces the rate-limiting enzyme of tryptophan (TRY) - kynurenine (KYN) pathway, indoleamine 2,3-dioxygenase (IDO). Activation of IDO shunts TRY metabolism from production of serotonin (substrate of antidepressant effect) and its derivatives: N-acetylserotonin (an agonist to the receptors of brain derived neurotropic factor), and melatonin (regulator of sleep and other circadian rhythms), towards production of KYN and its derivatives (anxiogenic, neurotoxic and pro-oxidant factors). Some of kynurenines up-regulate nitric oxide synthase (NOS). Concurrently with activation of IDO, IFNG induces guanosine triphosphate cyclohydrolase I (GTPCH), the rate limiting enzyme of GTP conversion into BH2 (and increases formation of a stable derivative of BH2, neopterin, at the expense of production of BH4, the mandatory co-factor of NOS). Combination of increased NOS activity (by kynurenines) with decreased formation of BH4 leads to the uncoupling of NOS with consequent shift of arginine metabolism from biosynthesis of NO to formation of superoxide anion and other free radicals, and exacerbation of depression, anxiety and cognitive impairment caused by kynurenines. Polymorphism of IFNG (+874) T/A gene, that encodes production of IFNG protein, impacts the IDO and GTPCH activity that might be assessed in humans by KYN/TRY ratio and neopterin concentrations in biological fluids (e. g., blood, urine and spinal fluid). The hypothesis of IFNG inducible IDO/GTPCH inflammation cascade helps to understand the increased association between aging, inflammation and aging-associated psychiatric and medical (insulin resistance, obesity) disorders. Evaluation of markers of IFNG-inducible inflammation cascade might be used to assess the severity of corresponding behavioral and cognitive changes and the efficacy of pharmacological interventions (e. g., IDO inhibitors).
C1 [Oxenkrug, Gregory] Tufts Univ, Sch Med, Psychiat & Inflammat Program, Dept Psychiat,Tufts Med Ctr, Boston, MA 02111 USA.
C3 Tufts University; Tufts Medical Center
RP Oxenkrug, G (corresponding author), Tufts Univ, Sch Med, Psychiat & Inflammat Program, Tufts Med Ctr, Boston, MA 02111 USA.
EM goxenkrug@tuftsmedicalcenter.org
CR [Anonymous], J CELL MOL MED
   [Anonymous], MONOAMINE OXIDASE IN
   [Anonymous], INT J NEUROPSYCHPHAR
   [Anonymous], AM J NEUROP IN PRESS
   [Anonymous], ALZHEIMERS DIS DEMEN
   [Anonymous], HORMONES AGE CANC
   [Anonymous], ACTA VITAMINOL ENZYM
   Anuradha B, 2008, PEDIATR INFECT DIS J, V27, P325, DOI 10.1097/INF.0b013e31816099e6
   Baran H, 1996, LIFE SCI, V58, P1891, DOI 10.1016/0024-3205(96)00173-7
   Belmaker RH, 2008, NEW ENGL J MED, V358, P55, DOI [10.1056/NEJMra073096, 10.1038/nrdp.2016.65]
   BENDER DA, 1990, BRIT J NUTR, V63, P27, DOI 10.1079/BJN19900089
   Bending D, 2011, J IMMUNOL, V186, P3373, DOI 10.4049/jimmunol.1003216
   Biolo G, 2006, NEPHROL DIAL TRANSPL, V21, P1317, DOI 10.1093/ndt/gfk033
   Bollati V, 2010, CHRONOBIOL INT, V27, P1093, DOI 10.3109/07420528.2010.490065
   Brandacher G, 2006, OBES SURG, V16, P541, DOI 10.1381/096089206776945066
   Breum L, 2003, AM J CLIN NUTR, V77, P1112, DOI 10.1093/ajcn/77.5.1112
   Campayo A, 2010, AM J PSYCHIAT, V167, P580, DOI 10.1176/appi.ajp.2009.09010038
   Capuron L, 2011, PHARMACOL THERAPEUT, V130, P226, DOI 10.1016/j.pharmthera.2011.01.014
   Capuron L, 2011, BIOL PSYCHIAT, V70, P175, DOI 10.1016/j.biopsych.2010.12.006
   Chrapko W, 2006, NEUROPSYCHOPHARMACOL, V31, P1286, DOI 10.1038/sj.npp.1300961
   CONNICK JH, 1985, MED HYPOTHESES, V18, P371, DOI 10.1016/0306-9877(85)90104-5
   Dantzer R, 2011, PSYCHONEUROENDOCRINO, V36, P426, DOI 10.1016/j.psyneuen.2010.09.012
   Dilman V., 1979, Serotonin in Health and Diseases, V5, P111
   Fahey JL, 2000, MECH AGEING DEV, V115, P1, DOI 10.1016/S0047-6374(00)00094-4
   Fernandes BS, 2011, J PSYCHIATR RES, V45, P995, DOI 10.1016/j.jpsychires.2011.03.002
   FINKELSTEIN JA, 1982, PHARMACOL BIOCHEM BE, V17, P939, DOI 10.1016/0091-3057(82)90476-2
   Franscini N, 2003, ARTERIOSCL THROM VAS, V23, pE50, DOI 10.1161/01.ATV.0000099785.65848.F1
   Frick B, 2004, CLIN BIOCHEM, V37, P684, DOI 10.1016/j.clinbiochem.2004.02.007
   Fridman AL, 2008, ONCOGENE, V27, P5975, DOI 10.1038/onc.2008.213
   Fuchs D, 2009, CURR MED CHEM, V16, P4644, DOI 10.2174/092986709789878247
   Grammer TB, 2009, CLIN CHEM, V55, P1135, DOI 10.1373/clinchem.2008.118844
   GRAMSBERGEN JBP, 1992, BRAIN RES, V588, P1, DOI 10.1016/0006-8993(92)91337-E
   GUILARTE TR, 1988, PHARMACOL BIOCHEM BE, V30, P665, DOI 10.1016/0091-3057(88)90080-9
   Guillemin GJ, 2002, REDOX REP, V7, P199, DOI 10.1179/135100002125000550
   Hasegawa-Ishii S, 2011, BRAIN BEHAV IMMUN, V25, P83, DOI 10.1016/j.bbi.2010.08.006
   HEINZEL B, 1992, BIOCHEM J, V281, P627, DOI 10.1042/bj2810627
   Henry CJ, 2009, BRAIN BEHAV IMMUN, V23, P309, DOI 10.1016/j.bbi.2008.09.002
   Henry CJ, 2008, J NEUROINFLAMM, V5, DOI 10.1186/1742-2094-5-15
   Hochstrasser T, 2011, NEUROSCIENCE, V184, P128, DOI 10.1016/j.neuroscience.2011.03.070
   Jang SW, 2010, P NATL ACAD SCI USA, V107, P3876, DOI 10.1073/pnas.0912531107
   Kanai M, 2009, MOL BRAIN, V2, DOI 10.1186/1756-6606-2-8
   Kikuchi H, 2011, J IMMUNOL, V186, P3015, DOI 10.4049/jimmunol.1000364
   Kim KS, 2009, MECH AGEING DEV, V130, P179, DOI 10.1016/j.mad.2008.11.004
   KISELEVA IP, 1980, VOP MED KHIM, V26, P458
   KOTAKE Y, 1975, ACTA VITAMINOL ENZYM, V29, P236
   Lapin IP, 2003, ADV EXP MED BIOL, V527, P121
   Lapin IP, 1996, ADV EXP MED BIOL, V398, P191
   LAPIN IP, 1969, LANCET, V1, P132
   Ledochowski M, 1999, CLIN CHIM ACTA, V282, P115, DOI 10.1016/S0009-8981(99)00019-4
   Leonard BE, 2007, NEUROCHEM RES, V32, P1749, DOI 10.1007/s11064-007-9385-y
   Lio D, 2002, EXP GERONTOL, V37, P315, DOI 10.1016/S0531-5565(01)00198-X
   Manev H, 2007, ARCH GEN PSYCHIAT, V64, P1333, DOI 10.1001/archpsyc.64.11.1333
   MCINTYRE IM, 1991, PROG NEURO-PSYCHOPH, V15, P561, DOI 10.1016/0278-5846(91)90031-U
   MELILLO G, 1994, J BIOL CHEM, V269, P8128
   Miller CL, 2006, BRAIN RES, V1073, P25, DOI 10.1016/j.brainres.2005.12.056
   MORONI F, 1988, NEUROSCI LETT, V94, P145, DOI 10.1016/0304-3940(88)90285-6
   Morris MS, 2010, J NUTR, V140, P103, DOI 10.3945/jn.109.114397
   Murr C, 2002, CURR DRUG METAB, V3, P175, DOI 10.2174/1389200024605082
   Niinisalo P, 2008, SCAND J CLIN LAB INV, V68, P767, DOI 10.1080/00365510802245685
   ORLIKOV AB, 1994, BIOL PSYCHIAT, V36, P97, DOI 10.1016/0006-3223(94)91189-4
   Oxenkrug G, 2005, ANN NY ACAD SCI, V1053, P334, DOI 10.1196/annals.1344.029
   Oxenkrug G, 2011, Am J Neuroprot Neuroregen, V3, P48
   Oxenkrug G, 2011, J NEURAL TRANSM, V118, P271, DOI 10.1007/s00702-010-0525-1
   Oxenkrug G, 2001, ANN NY ACAD SCI, V939, P190
   Oxenkrug G. F., 1999, Neurobiology (Budapest), V7, P213
   Oxenkrug G F, 1994, Int J Neurosci, V77, P237
   OXENKRUG GF, 1984, J PINEAL RES, V1, P181, DOI 10.1111/j.1600-079X.1984.tb00209.x
   OXENKRUG GF, 1990, J PINEAL RES, V9, P1, DOI 10.1111/j.1600-079X.1990.tb00688.x
   Oxenkrug GF, 1997, VOP MED KHIM, V43, P522
   OXENKRUG GF, 1991, OX MED PUBL, P110
   OXENKRUG GF, 1983, PSYCHIAT RES, V10, P125, DOI 10.1016/0165-1781(83)90111-7
   OXENKRUG GF, 1984, BIOL PSYCHIAT, V19, P413
   Oxenkrug GF, 2011, J NEURAL TRANSM, V118, P75, DOI 10.1007/s00702-010-0475-7
   Oxenkrug GF, 2010, ISR J PSYCHIATR REL, V47, P56
   Oxenkrug GF, 2010, ANN NY ACAD SCI, V1199, P121, DOI 10.1111/j.1749-6632.2009.05354.x
   Oxenkrug G, 2010, J NEURAL TRANSM, V117, P23, DOI 10.1007/s00702-009-0341-7
   OZAKI Y, 1987, BIOCHEM BIOPH RES CO, V144, P1147, DOI 10.1016/0006-291X(87)91431-8
   Pérez-Severiano F, 1998, NEUROCHEM RES, V23, P1297, DOI 10.1023/A:1020700401678
   Perrey C, 1998, TRANSPL IMMUNOL, V6, P193, DOI 10.1016/S0966-3274(98)80045-2
   Pertovaara M, 2006, MECH AGEING DEV, V127, P497, DOI 10.1016/j.mad.2006.01.020
   Pitche Palokinam T, 2005, Sante, V15, P205
   POU S, 1992, J BIOL CHEM, V267, P24173
   Prakhie IV, 1998, INT J NEUROPSYCHOPH, V1, P35, DOI 10.1017/S1461145798001096
   Pravica V, 2000, HUM IMMUNOL, V61, P863, DOI 10.1016/S0198-8859(00)00167-1
   Qu TY, 2000, NEUROBIOL AGING, V21, P647, DOI 10.1016/S0197-4580(00)00167-6
   Raitala A, 2005, SCAND J IMMUNOL, V61, P387, DOI 10.1111/j.1365-3083.2005.01586.x
   Rodríguez MI, 2007, J PINEAL RES, V42, P272, DOI 10.1111/j.1600-079X.2006.00416.x
   Rongvaux A, 2003, BIOESSAYS, V25, P683, DOI 10.1002/bies.10297
   Rosczyk HA, 2008, EXP GERONTOL, V43, P840, DOI 10.1016/j.exger.2008.06.004
   Rudzite V, 2005, PTERIDINES, V16, P190
   Russo S, 2003, PSYCHOSOM MED, V65, P665, DOI 10.1097/01.PSY.0000078188.74020.CC
   Santarelli L, 2003, SCIENCE, V301, P805, DOI 10.1126/science.1083328
   Sarasin-Filipowicz M, 2008, P NATL ACAD SCI USA, V105, P7034, DOI 10.1073/pnas.0707882105
   Schennach H, 2002, CLIN CHEM, V48, P643
   SCHOEDON G, 1986, J INTERFERON RES, V6, P697, DOI 10.1089/jir.1986.6.697
   Schwarcz R, 2002, J PHARMACOL EXP THER, V303, P1, DOI 10.1124/jpet.102.034439
   Shelton RC, 2011, MOL PSYCHIATR, V16, P751, DOI 10.1038/mp.2010.52
   Shen J, 2010, AM J CLIN NUTR, V91, P337, DOI 10.3945/ajcn.2009.28571
   Shimoji M, 1999, J NEUROCHEM, V72, P757, DOI 10.1046/j.1471-4159.1999.0720757.x
   Sparkman NL, 2008, NEUROIMMUNOMODULAT, V15, P323, DOI 10.1159/000156474
   Spencer ME, 2010, J GERONTOL A-BIOL, V65, P855, DOI 10.1093/gerona/glq066
   Stewart JC, 2007, ARCH GEN PSYCHIAT, V64, P225, DOI 10.1001/archpsyc.64.2.225
   Tambur AR, 2001, TRANSPLANTATION, V71, P1475, DOI 10.1097/00007890-200105270-00020
   Urbanska EM, 2006, PHARMACOL REP, V58, P507
   Vasto S, 2007, MECH AGEING DEV, V128, P83, DOI 10.1016/j.mad.2006.11.015
   Wang YX, 2010, BRAIN BEHAV IMMUN, V24, P201, DOI 10.1016/j.bbi.2009.06.152
   White RE, 2010, STEROIDS, V75, P788, DOI 10.1016/j.steroids.2009.12.007
   Wonodi I, 2010, SCHIZOPHRENIA BULL, V36, P211, DOI 10.1093/schbul/sbq002
   Zawilska JB, 2007, PHARMACOL REP, V59, P408
   Zhdanova IV, 2011, J BIOL RHYTHM, V26, P149, DOI 10.1177/0748730410395849
NR 110
TC 49
Z9 51
U1 1
U2 10
PU INT SOC AGING & DISEASE
PI FORT WORTH
PA EDITORIAL OFF, 3400 CAMP BOWIE BLVD, FORT WORTH, TX 76106 USA
SN 2152-5250
J9 AGING DIS
JI Aging Dis.
PD DEC
PY 2011
VL 2
IS 6
BP 474
EP 486
PG 13
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA V32KS
UT WOS:000208950700005
PM 22396896
DA 2025-06-11
ER

PT J
AU Hall, JA
   Dominy, JE
   Lee, Y
   Puigserver, P
AF Hall, Jessica A.
   Dominy, John E.
   Lee, Yoonjin
   Puigserver, Pere
TI The sirtuin family's role in aging and age-associated pathologies
SO JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Review
ID FATTY-ACID OXIDATION; CALORIE RESTRICTION; GENE-EXPRESSION; HISTONE H3;
   IN-VIVO; SIRT3-MEDIATED DEACETYLATION; MITOCHONDRIAL-FUNCTION;
   ENERGY-EXPENDITURE; TUMOR-SUPPRESSOR; MAMMALIAN SIR2
AB The 7 mammalian sirtuin proteins compose a protective cavalry of enzymes that can be invoked by cells to aid in the defense against a vast array of stressors. The pathologies associated with aging, such as metabolic syndrome, neurodegeneration, and cancer, are either caused by or exacerbated by a lifetime of chronic stress. As such, the activation of sirtuin proteins could provide a therapeutic approach to buffer against chronic stress and ameliorate age-related decline. Here we review experimental evidence both for and against this proposal, as well as the implications that isoform-specific sirtuin activation may have for healthy aging in humans.
C1 Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.
   Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; Dana-Farber
   Cancer Institute; Harvard University; Harvard Medical School
RP Puigserver, P (corresponding author), Dana Farber Canc Inst, 450 Brookline Ave,CLSB 11144, Boston, MA 02215 USA.
EM pere_puigserver@dfci.harvard.edu
FU American Heart Association predoctoral fellowship; NIH National Research
   Service Award Kirschstein fellowship; Ewha Womans University;
   Dana-Farber Cancer Institute; American Diabetes Association; Department
   of Defense; NIH/NIDDK [RO1069966]
FX J.A. Hall is supported by an American Heart Association predoctoral
   fellowship. J.E. Dominy is supported in part by an NIH National Research
   Service Award Kirschstein fellowship. Y. Lee is funded by a scholarship
   from Ewha Womans University. P. Puigserver has received support from the
   Dana-Farber Cancer Institute, American Diabetes Association, Department
   of Defense, and NIH/NIDDK (grant RO1069966).
CR Ahn BH, 2008, P NATL ACAD SCI USA, V105, P14447, DOI 10.1073/pnas.0803790105
   Alcendor RR, 2007, CIRC RES, V100, P1512, DOI 10.1161/01.RES.0000267723.65696.4a
   Alhazzazi TY, 2011, BBA-REV CANCER, V1816, P80, DOI 10.1016/j.bbcan.2011.04.004
   Araki T, 2004, SCIENCE, V305, P1010, DOI 10.1126/science.1098014
   Banks AS, 2008, CELL METAB, V8, P333, DOI 10.1016/j.cmet.2008.08.014
   Bao JJ, 2010, FREE RADICAL BIO MED, V49, P1230, DOI 10.1016/j.freeradbiomed.2010.07.009
   Barber MF, 2012, NATURE, V487, P114, DOI 10.1038/nature11043
   Baur JA, 2012, NAT REV DRUG DISCOV, V11, P443, DOI 10.1038/nrd3738
   Beirowski B, 2011, P NATL ACAD SCI USA, V108, pE952, DOI 10.1073/pnas.1104969108
   Bellizzi D, 2005, GENOMICS, V85, P258, DOI 10.1016/j.ygeno.2004.11.003
   Bellizzi D, 2007, GENOMICS, V89, P143, DOI 10.1016/j.ygeno.2006.09.004
   Blum CA, 2011, J MED CHEM, V54, P417, DOI 10.1021/jm100861p
   Bobrowska A, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034805
   Bradbury C, 2005, LEUKEMIA, V19, P1751, DOI 10.1038/sj.leu.2403910
   Burnett C, 2011, NATURE, V477, P482, DOI 10.1038/nature10296
   Cantó C, 2009, NATURE, V458, P1056, DOI 10.1038/nature07813
   Chen D, 2007, TRENDS MOL MED, V13, P64, DOI 10.1016/j.molmed.2006.12.004
   Cimen H, 2010, BIOCHEMISTRY-US, V49, P304, DOI 10.1021/bi901627u
   Colman RJ, 2009, SCIENCE, V325, P201, DOI 10.1126/science.1173635
   Das C, 2009, NATURE, V459, P113, DOI 10.1038/nature07861
   Dittenhafer-Reed KE, 2011, CHEMBIOCHEM, V12, P281, DOI 10.1002/cbic.201000434
   Dominy JE, 2011, COLD SH Q B, V76, P203, DOI 10.1101/sqb.2012.76.010843
   Donmez G, 2012, J NEUROSCI, V32, P124, DOI 10.1523/JNEUROSCI.3442-11.2012
   Donmez G, 2010, CELL, V142, P320, DOI 10.1016/j.cell.2010.06.020
   Dryden SC, 2003, MOL CELL BIOL, V23, P3173, DOI 10.1128/MCB.23.9.3173-3185.2003
   Du JT, 2011, SCIENCE, V334, P806, DOI 10.1126/science.1207861
   Erion DM, 2009, P NATL ACAD SCI USA, V106, P11288, DOI 10.1073/pnas.0812931106
   Fang YJ, 2011, CANCER LETT, V306, P10, DOI 10.1016/j.canlet.2011.02.019
   Feige JN, 2008, CELL METAB, V8, P347, DOI 10.1016/j.cmet.2008.08.017
   Fernandez-Marcos PJ, 2012, SCI REP-UK, V2, DOI 10.1038/srep00425
   Finley LWS, 2011, CANCER CELL, V19, P416, DOI 10.1016/j.ccr.2011.02.014
   Firestein R, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002020
   Ford J, 2005, CANCER RES, V65, P10457, DOI 10.1158/0008-5472.CAN-05-1923
   Frye RA, 2000, BIOCHEM BIOPH RES CO, V273, P793, DOI 10.1006/bbrc.2000.3000
   Gerhart-Hines Z, 2007, EMBO J, V26, P1913, DOI 10.1038/sj.emboj.7601633
   Gerhart-Hines Z, 2011, MOL CELL, V44, P851, DOI 10.1016/j.molcel.2011.12.005
   Gillum MP, 2011, DIABETES, V60, P3235, DOI 10.2337/db11-0616
   GRINKER JA, 1995, OBES RES, V3, P435, DOI 10.1002/j.1550-8528.1995.tb00173.x
   Hafner AV, 2010, AGING-US, V2, P914, DOI 10.18632/aging.100252
   Haigis MC, 2006, CELL, V126, P941, DOI 10.1016/j.cell.2006.06.057
   Haigis MC, 2012, CANCER RES, V72, P2468, DOI 10.1158/0008-5472.CAN-11-3633
   Heltweg B, 2006, CANCER RES, V66, P4368, DOI 10.1158/0008-5472.CAN-05-3617
   Herranz D, 2010, NAT COMMUN, V1, DOI 10.1038/ncomms1001
   Hida Y, 2007, ARCH DERMATOL RES, V299, P103, DOI 10.1007/s00403-006-0725-6
   Hirschey MD, 2011, MOL CELL, V44, P177, DOI 10.1016/j.molcel.2011.07.019
   Hirschey MD, 2010, NATURE, V464, P121, DOI 10.1038/nature08778
   Houtkooper RH, 2012, NAT REV MOL CELL BIO, V13, P225, DOI 10.1038/nrm3293
   Huffman DM, 2007, CANCER RES, V67, P6612, DOI 10.1158/0008-5472.CAN-07-0085
   Jeong H, 2012, NAT MED, V18, P159, DOI 10.1038/nm.2559
   Jiang ML, 2012, NAT MED, V18, P153, DOI 10.1038/nm.2558
   Jin YH, 2008, BIOCHEM BIOPH RES CO, V368, P690, DOI 10.1016/j.bbrc.2008.01.114
   Jing EX, 2007, CELL METAB, V6, P105, DOI 10.1016/j.cmet.2007.07.003
   Jing EX, 2011, P NATL ACAD SCI USA, V108, P14608, DOI 10.1073/pnas.1111308108
   Kaeberlein M, 1999, GENE DEV, V13, P2570, DOI 10.1101/gad.13.19.2570
   Kaidi A, 2010, SCIENCE, V329, P1348, DOI 10.1126/science.1192049
   Kajimura S, 2008, GENE DEV, V22, P1397, DOI 10.1101/gad.1666108
   Kanfi Y, 2012, NATURE, V483, P218, DOI 10.1038/nature10815
   Kanfi Y, 2010, AGING CELL, V9, P162, DOI 10.1111/j.1474-9726.2009.00544.x
   Kawahara TLA, 2009, CELL, V136, P62, DOI 10.1016/j.cell.2008.10.052
   Kendrick AA, 2011, BIOCHEM J, V433, P505, DOI 10.1042/BJ20100791
   Kim HS, 2011, CANCER CELL, V20, P487, DOI 10.1016/j.ccr.2011.09.004
   Kim HS, 2010, CELL METAB, V12, P224, DOI 10.1016/j.cmet.2010.06.009
   Kim HS, 2010, CANCER CELL, V17, P41, DOI 10.1016/j.ccr.2009.11.023
   Kim SC, 2006, MOL CELL, V23, P607, DOI 10.1016/j.molcel.2006.06.026
   Koubova J, 2003, GENE DEV, V17, P313, DOI 10.1101/gad.1052903
   Krishnan J, 2012, GENE DEV, V26, P259, DOI 10.1101/gad.180406.111
   Lain S, 2008, CANCER CELL, V13, P454, DOI 10.1016/j.ccr.2008.03.004
   Lescai F, 2009, EUR J HUM GENET, V17, P1515, DOI 10.1038/ejhg.2009.54
   Li X, 2007, MOL CELL, V28, P91, DOI 10.1016/j.molcel.2007.07.032
   Liang FX, 2009, NAT REV ENDOCRINOL, V5, P367, DOI 10.1038/nrendo.2009.101
   Lim JH, 2010, MOL CELL, V38, P864, DOI 10.1016/j.molcel.2010.05.023
   Lombard DB, 2007, MOL CELL BIOL, V27, P8807, DOI 10.1128/MCB.01636-07
   Lombard David B, 2011, Handb Exp Pharmacol, V206, P163, DOI 10.1007/978-3-642-21631-2_8
   Luthi-Carter R, 2010, P NATL ACAD SCI USA, V107, P7927, DOI 10.1073/pnas.1002924107
   Mao ZY, 2011, SCIENCE, V332, P1443, DOI 10.1126/science.1202723
   Mattison JA, 2012, NATURE, V489, P318, DOI 10.1038/nature11432
   Michishita E, 2009, CELL CYCLE, V8, P2664, DOI 10.4161/cc.8.16.9367
   Milne JC, 2007, NATURE, V450, P712, DOI 10.1038/nature06261
   Minor RK, 2011, SCI REP-UK, V1, DOI 10.1038/srep00070
   Mostoslavsky R, 2006, CELL, V124, P315, DOI 10.1016/J.CEL.2005.11.044
   Moynihan KA, 2005, CELL METAB, V2, P105, DOI 10.1016/j.cmet.2005.07.001
   Nakagawa T, 2009, CELL, V137, P560, DOI 10.1016/j.cell.2009.02.026
   Nasrin N, 2010, J BIOL CHEM, V285, P31995, DOI 10.1074/jbc.M110.124164
   North BJ, 2007, J BIOL CHEM, V282, P19546, DOI 10.1074/jbc.M702990200
   Ota H, 2006, ONCOGENE, V25, P176, DOI 10.1038/sj.onc.1209049
   Outeiro TF, 2007, SCIENCE, V317, P516, DOI 10.1126/science.1143780
   Palacios OM, 2009, AGING-US, V1, P771, DOI 10.18632/aging.100075
   Pallos J, 2008, HUM MOL GENET, V17, P3767, DOI 10.1093/hmg/ddn273
   Pandithage R, 2008, J CELL BIOL, V180, P915, DOI 10.1083/jcb.200707126
   Peng C, 2011, MOL CELL PROTEOMICS, V10, DOI 10.1074/mcp.M111.012658
   Pfluger PT, 2008, P NATL ACAD SCI USA, V105, P9793, DOI 10.1073/pnas.0802917105
   Purushotham A, 2009, CELL METAB, V9, P327, DOI 10.1016/j.cmet.2009.02.006
   Qiang L, 2012, CELL, V150, P620, DOI 10.1016/j.cell.2012.06.027
   Qiang L, 2011, CELL METAB, V14, P758, DOI 10.1016/j.cmet.2011.10.007
   Qiu XL, 2010, CELL METAB, V12, P662, DOI 10.1016/j.cmet.2010.11.015
   Rodgers JT, 2007, P NATL ACAD SCI USA, V104, P12861, DOI 10.1073/pnas.0702509104
   Rose G, 2003, EXP GERONTOL, V38, P1065, DOI 10.1016/S0531-5565(03)00209-2
   Sasaki Y, 2006, J NEUROSCI, V26, P8484, DOI 10.1523/JNEUROSCI.2320-06.2006
   Schwer B, 2010, P NATL ACAD SCI USA, V107, P21790, DOI 10.1073/pnas.1016306107
   Schwer B, 2009, AGING CELL, V8, P604, DOI 10.1111/j.1474-9726.2009.00503.x
   Seligson DB, 2009, AM J PATHOL, V174, P1619, DOI 10.2353/ajpath.2009.080874
   Shi T, 2005, J BIOL CHEM, V280, P13560, DOI 10.1074/jbc.M414670200
   Shimazu T, 2010, CELL METAB, V12, P654, DOI 10.1016/j.cmet.2010.11.003
   Someya S, 2010, CELL, V143, P802, DOI 10.1016/j.cell.2010.10.002
   Stein S, 2010, EUR HEART J, V31, P2301, DOI 10.1093/eurheartj/ehq107
   Stuenkel Walter, 2007, Biotechnology Journal, V2, P1360, DOI 10.1002/biot.200700087
   Sundaresan NR, 2009, J CLIN INVEST, V119, P2758, DOI 10.1172/JCI39162
   Suzuki K, 2012, ONCOL REP, V27, P1726, DOI 10.3892/or.2012.1750
   Tang MM, 2011, MOL THER, V19, P60, DOI 10.1038/mt.2010.187
   Tao RD, 2010, MOL CELL, V40, P893, DOI 10.1016/j.molcel.2010.12.013
   Timmers S, 2011, CELL METAB, V14, P612, DOI 10.1016/j.cmet.2011.10.002
   Vakhrusheva O, 2008, CIRC RES, V102, P703, DOI 10.1161/CIRCRESAHA.107.164558
   Vaquero A, 2006, GENE DEV, V20, P1256, DOI 10.1101/gad.1412706
   Wang F, 2007, AGING CELL, V6, P505, DOI 10.1111/j.1474-9726.2007.00304.x
   Wang F, 2009, MOL BIOL CELL, V20, P801, DOI 10.1091/mbc.E08-06-0647
   Wang RH, 2008, MOL CELL, V32, P11, DOI 10.1016/j.molcel.2008.09.011
   Wang RH, 2008, CANCER CELL, V14, P312, DOI 10.1016/j.ccr.2008.09.001
   Wang RH, 2010, INT J BIOL SCI, V6, P682
   Wellen KE, 2012, NAT REV MOL CELL BIO, V13, P270, DOI 10.1038/nrm3305
   Yang B, 2009, CELL CYCLE, V8, P2662, DOI 10.4161/cc.8.16.9329
   Yang L, 2011, J PROTEOME RES, V10, P4134, DOI 10.1021/pr200313x
   Yechoor VK, 2004, P NATL ACAD SCI USA, V101, P16525, DOI 10.1073/pnas.0407574101
   Zhang QJ, 2008, CARDIOVASC RES, V80, P191, DOI 10.1093/cvr/cvn224
   Zhong L, 2010, CELL, V140, P280, DOI 10.1016/j.cell.2009.12.041
NR 124
TC 186
Z9 195
U1 2
U2 50
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA
SN 0021-9738
EI 1558-8238
J9 J CLIN INVEST
JI J. Clin. Invest.
PD MAR
PY 2013
VL 123
IS 3
BP 973
EP 979
DI 10.1172/JCI64094
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 101BE
UT WOS:000315749400008
PM 23454760
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Simcox, JA
   McClain, DA
AF Simcox, Judith A.
   McClain, Donald A.
TI Iron and Diabetes Risk
SO CELL METABOLISM
LA English
DT Review
ID INSULIN SECRETORY CAPACITY; HEPATIC GLUCOSE-PRODUCTION; INDUCED
   OXIDATIVE STRESS; DRUG TARGET MITONEET; BETA-CELL FUNCTION; SERUM
   FERRITIN; METABOLIC SYNDROME; LIPID-METABOLISM; BLOOD-PRESSURE;
   ADIPOSE-TISSUE
AB Iron overload is a risk factor for diabetes. The link between iron and diabetes was first recognized in pathologic conditions-hereditary hemochromatosis and thalassemia-but high levels of dietary iron also impart diabetes risk. Iron plays a direct and causal role in diabetes pathogenesis mediated both by beta cell failure and insulin resistance. Iron also regulates metabolism in most tissues involved in fuel homeostasis, with the adipocyte in particular serving an iron-sensing role. The underlying molecular mechanisms mediating these effects are numerous and incompletely understood but include oxidant stress and modulation of adipokines and intracellular signal transduction pathways.
C1 [Simcox, Judith A.; McClain, Donald A.] Univ Utah, Sch Med, Dept Med, Salt Lake City, UT 84132 USA.
   [Simcox, Judith A.; McClain, Donald A.] Univ Utah, Sch Med, Dept Biochem, Salt Lake City, UT 84132 USA.
   [McClain, Donald A.] VA Med Ctr, Res Serv, Salt Lake City, UT 84132 USA.
C3 Utah System of Higher Education; University of Utah; Utah System of
   Higher Education; University of Utah
RP McClain, DA (corresponding author), Univ Utah, Sch Med, Dept Med, Salt Lake City, UT 84132 USA.
EM donald.mcclain@hsc.utah.edu
OI Simcox, Judith/0000-0001-7350-6342; McClain, Don/0000-0002-3310-2359
FU NIH [DK081842, T32DK091317]; Research Service of the Veterans
   Administration; Marilyn Jane Robinson Foundation
FX This work was supported by the NIH (DK081842 to D. M. and T32DK091317 to
   J.S.), the Research Service of the Veterans Administration, and the
   Marilyn Jane Robinson Foundation. The authors would like to acknowledge
   the assistance of Amnon Schlegel for assistance in reviewing the
   manuscript.
CR Abraham D, 2006, DIABETOLOGIA, V49, P2546, DOI 10.1007/s00125-006-0445-7
   Afkhami-Ardekani M, 2009, J DIABETES COMPLICAT, V23, P194, DOI 10.1016/j.jdiacomp.2007.11.006
   Anderson CP, 2012, BBA-MOL CELL RES, V1823, P1468, DOI 10.1016/j.bbamcr.2012.05.010
   Andrews NC, 2007, ANNU REV PHYSIOL, V69, P69, DOI 10.1146/annurev.physiol.69.031905.164337
   Andriopoulos B, 2009, NAT GENET, V41, P482, DOI 10.1038/ng.335
   Ang SO, 2002, NAT GENET, V32, P614, DOI 10.1038/ng1019
   Aragonés J, 2009, CELL METAB, V9, P11, DOI 10.1016/j.cmet.2008.10.001
   Arita Y, 1999, BIOCHEM BIOPH RES CO, V257, P79, DOI 10.1006/bbrc.1999.0255
   Ausk KJ, 2008, OBESITY, V16, P2356, DOI 10.1038/oby.2008.353
   Azevedo-Martins AK, 2003, DIABETES, V52, P93, DOI 10.2337/diabetes.52.1.93
   Babcock M, 1997, SCIENCE, V276, P1709, DOI 10.1126/science.276.5319.1709
   Baker KS, 2007, BLOOD, V109, P1765, DOI 10.1182/blood-2006-05-022335
   BAQUER NZ, 1982, ENZYME, V27, P61
   Bekri S, 2006, GASTROENTEROLOGY, V131, P788, DOI 10.1053/j.gastro.2006.07.007
   Belfort MB, 2008, INT J EPIDEMIOL, V37, P301, DOI 10.1093/ije/dyn002
   Boeckel JN, 2011, P NATL ACAD SCI USA, V108, P3276, DOI 10.1073/pnas.1008098108
   BOFILL C, 1994, METABOLISM, V43, P614, DOI 10.1016/0026-0495(94)90204-6
   BOREL MJ, 1993, AM J PHYSIOL, V264, pE380, DOI 10.1152/ajpendo.1993.264.3.E380
   Borgna-Pignatti C, 1998, ANN NY ACAD SCI, V850, P227, DOI 10.1111/j.1749-6632.1998.tb10479.x
   Borgna-Pignatti C, 2004, HAEMATOLOGICA, V89, P1187
   Bourque SL, 2012, ENDOCRINOLOGY, V153, P1174, DOI 10.1210/en.2011-1700
   Bowers K, 2011, DIABETES CARE, V34, P1557, DOI 10.2337/dc11-0134
   BRINK B, 1976, J LAB CLIN MED, V88, P725
   Brion MJA, 2008, AM J CLIN NUTR, V88, P1126, DOI 10.1093/ajcn/88.4.1126
   Brunet A, 2004, SCIENCE, V303, P2011, DOI 10.1126/science.1094637
   Buysschaert M, 1997, DIABETES METAB, V23, P308
   Cairo G, 1997, BLOOD, V89, P2546, DOI 10.1182/blood.V89.7.2546
   Cepeda-Lopez AC, 2011, AM J CLIN NUTR, V93, P975, DOI 10.3945/ajcn.110.005439
   Chaliasos N, 2010, ACTA HAEMATOL-BASEL, V124, P191, DOI 10.1159/000320274
   Cheng K, 2010, J CLIN INVEST, V120, P2171, DOI 10.1172/JCI35846
   Colca JR, 2004, AM J PHYSIOL-ENDOC M, V286, pE252, DOI 10.1152/ajpendo.00424.2003
   Condò I, 2010, HUM MOL GENET, V19, P1221, DOI 10.1093/hmg/ddp592
   Cooksey RC, 2004, ENDOCRINOLOGY, V145, P5305, DOI 10.1210/en.2004-0392
   Cooksey RC, 2010, AM J PHYSIOL-ENDOC M, V298, pE1236, DOI 10.1152/ajpendo.00022.2010
   D'Alessio F, 2012, J HEPATOL, V57, P1052, DOI 10.1016/j.jhep.2012.06.015
   DAVIS RJ, 1986, J BIOL CHEM, V261, P8708
   De Domenico I, 2008, NAT REV MOL CELL BIO, V9, P72, DOI 10.1038/nrm2295
   DMOCHOWSKI K, 1993, J CLIN ENDOCR METAB, V77, P478, DOI 10.1210/jc.77.2.478
   Dongiovanni P, 2011, J HEPATOL, V55, P920, DOI 10.1016/j.jhep.2011.05.008
   Eisenstein RS, 2003, J NUTR, V133, p1510S, DOI 10.1093/jn/133.5.1510S
   Facchini FS, 2002, GASTROENTEROLOGY, V122, P931, DOI 10.1053/gast.2002.32403
   Facchini FS, 1998, DIABETES CARE, V21, P2190, DOI 10.2337/diacare.21.12.2190a
   Faller M, 2007, NAT STRUCT MOL BIOL, V14, P23, DOI 10.1038/nsmb1182
   Farahani P, 2004, OBES RES, V12, P191, DOI 10.1038/oby.2004.26
   Fargnoli JL, 2008, AM J CLIN NUTR, V88, P1213, DOI 10.3945/ajcn.2008.26480
   Feder JN, 1996, NAT GENET, V13, P399, DOI 10.1038/ng0896-399
   Fernández-Real JM, 2002, DIABETES CARE, V25, P2249, DOI 10.2337/diacare.25.12.2249
   Fernández-Real JM, 2005, CLIN CHEM, V51, P1201, DOI 10.1373/clinchem.2004.046847
   Fernández-Real JM, 2002, DIABETES, V51, P1000, DOI 10.2337/diabetes.51.4.1000
   Fernández-Real JM, 2002, DIABETES, V51, P2348, DOI 10.2337/diabetes.51.8.2348
   Fernández-Real JM, 2007, DIABETES CARE, V30, P616, DOI 10.2337/dc06-1581
   Festa M, 2000, J BIOL CHEM, V275, P36708, DOI 10.1074/jbc.M004988200
   Fleming DJ, 2002, AM J CLIN NUTR, V76, P1375, DOI 10.1093/ajcn/76.6.1375
   Fleming DJ, 2001, AM J CLIN NUTR, V73, P638
   Ford ES, 1999, DIABETES CARE, V22, P1978, DOI 10.2337/diacare.22.12.1978
   Forouhi NG, 2007, DIABETOLOGIA, V50, P949, DOI 10.1007/s00125-007-0604-5
   Gabrielsen JS, 2012, J CLIN INVEST, V122, P3529, DOI 10.1172/JCI44421
   Gamberini Maria Rita, 2008, Pediatr Endocrinol Rev, V6 Suppl 1, P158
   Ganz T, 2011, BLOOD, V117, P4425, DOI 10.1182/blood-2011-01-258467
   Ganz T, 2009, SEMIN HEMATOL, V46, P387, DOI 10.1053/j.seminhematol.2009.06.001
   Gillum RF, 2001, INT J OBESITY, V25, P639, DOI 10.1038/sj.ijo.0801561
   Handschin C, 2005, CELL, V122, P505, DOI 10.1016/j.cell.2005.06.040
   Hardie DG, 2011, GENE DEV, V25, P1895, DOI 10.1101/gad.17420111
   Hatunic M, 2010, METABOLISM, V59, P1811, DOI 10.1016/j.metabol.2010.06.005
   Hatunic M, 2010, METABOLISM, V59, P380, DOI 10.1016/j.metabol.2009.08.006
   Haurie V, 2003, J BIOL CHEM, V278, P45391, DOI 10.1074/jbc.M307447200
   HENDERSON SA, 1986, AM J PHYSIOL, V250, pE414, DOI 10.1152/ajpendo.1986.250.4.E414
   Hentze MW, 2010, CELL, V142, P24, DOI 10.1016/j.cell.2010.06.028
   Hoffmeister PA, 2004, J PEDIAT HEMATOL ONC, V26, P81, DOI 10.1097/00043426-200402000-00003
   HOSTETTLERALLEN R, 1993, J NUTR, V123, P1656, DOI 10.1093/jn/123.10.1656
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Hotamisligil GS, 2003, INT J OBESITY, V27, pS53, DOI 10.1038/sj.ijo.0802502
   Hou XY, 2008, J BIOL CHEM, V283, P20015, DOI 10.1074/jbc.M802187200
   Houschyar KS, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-54
   Houtkooper RH, 2012, NAT REV MOL CELL BIO, V13, P225, DOI 10.1038/nrm3293
   Hramiak IM, 1997, CLIN INVEST MED, V20, P110
   Huang JH, 2007, J BIOL CHEM, V282, P37501, DOI 10.1074/jbc.M703625200
   Huang JY, 2011, DIABETES, V60, P80, DOI 10.2337/db10-0593
   Hudson DM, 2010, AM J PHYSIOL-GASTR L, V298, pG425, DOI 10.1152/ajpgi.00453.2009
   Inagaki T, 2009, GENES CELLS, V14, P991, DOI 10.1111/j.1365-2443.2009.01326.x
   Iwasaki T, 2005, DIABETES CARE, V28, P2486, DOI 10.2337/diacare.28.10.2486
   Jaruratanasirikul S, 2008, EUR J PEDIATR, V167, P873, DOI 10.1007/s00431-007-0602-0
   Jehn M, 2004, DIABETES CARE, V27, P2422, DOI 10.2337/diacare.27.10.2422
   Jiang CT, 2011, DIABETES, V60, P2484, DOI 10.2337/db11-0174
   Jiang R, 2004, JAMA-J AM MED ASSOC, V291, P711, DOI 10.1001/jama.291.6.711
   Joitihan HA, 2008, MOL MED, V14, P98, DOI 10.2119/2007-00114.Jouihan
   Jomova K, 2011, TOXICOLOGY, V283, P65, DOI 10.1016/j.tox.2011.03.001
   Kahn BB, 1998, CELL, V92, P593, DOI 10.1016/S0092-8674(00)81125-3
   Kahn SE, 2003, DIABETOLOGIA, V46, P3, DOI 10.1007/s00125-002-1009-0
   Kaneto H, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/453892
   Knutson MD, 2005, P NATL ACAD SCI USA, V102, P1324, DOI 10.1073/pnas.0409409102
   Koch RO, 2003, HISTOL HISTOPATHOL, V18, P1095, DOI 10.14670/HH-18.1095
   Kriska AM, 2003, AM J EPIDEMIOL, V158, P669, DOI 10.1093/aje/kwg191
   Kusminski CM, 2012, NAT MED, V18, P1539, DOI 10.1038/nm.2899
   Lan F, 2008, J BIOL CHEM, V283, P27628, DOI 10.1074/jbc.M805711200
   Lenzen S, 1996, FREE RADICAL BIO MED, V20, P463, DOI 10.1016/0891-5849(96)02051-5
   Lewis RM, 2001, METABOLISM, V50, P562, DOI 10.1053/meta.2001.22516
   Li YJ, 2012, CELL METAB, V15, P895, DOI 10.1016/j.cmet.2012.04.021
   Liuzzi JP, 2006, P NATL ACAD SCI USA, V103, P13612, DOI 10.1073/pnas.0606424103
   Lobmayr L, 2005, GENE, V354, P157, DOI 10.1016/j.gene.2005.04.040
   Long YC, 2006, J CLIN INVEST, V116, P1776, DOI 10.1172/JCI29044
   Lowell BB, 2005, SCIENCE, V307, P384, DOI 10.1126/science.1104343
   Mackenzie B, 2006, PFLUG ARCH EUR J PHY, V451, P544, DOI 10.1007/s00424-005-1494-3
   Mastrogiannaki M, 2009, J CLIN INVEST, V119, P1159, DOI 10.1172/JCI38499
   McClain DA, 2006, DIABETOLOGIA, V49, P1661, DOI 10.1007/s00125-006-0200-0
   McClain DA, 2013, J MOL MED, V91, P59, DOI 10.1007/s00109-012-0961-5
   McClung JP, 2008, J NUTR, V138, P1293, DOI 10.1093/jn/138.7.1293
   Mendler MH, 1999, GASTROENTEROLOGY, V117, P1155, DOI 10.1016/S0016-5085(99)70401-4
   MERKEL PA, 1988, NEW ENGL J MED, V318, P809, DOI 10.1056/NEJM198803313181303
   Messina MF, 2002, J ENDOCRINOL INVEST, V25, P497, DOI 10.1007/BF03345490
   Meynard D, 2009, NAT GENET, V41, P478, DOI 10.1038/ng.320
   Minamiyama Y, 2010, AM J PHYSIOL-ENDOC M, V298, pE1140, DOI 10.1152/ajpendo.00620.2009
   Minard KI, 2005, J BIOL CHEM, V280, P39890, DOI 10.1074/jbc.M509461200
   Moirand R, 1997, ANN INTERN MED, V127, P105, DOI 10.7326/0003-4819-127-2-199707150-00002
   Mojiminiyi OA, 2008, NUTR METAB CARDIOVAS, V18, P559, DOI 10.1016/j.numecd.2007.07.007
   Monahan BJ, 2008, NAT STRUCT MOL BIOL, V15, P873, DOI 10.1038/nsmb.1452
   Nappi AJ, 1998, BBA-GEN SUBJECTS, V1380, P55, DOI 10.1016/S0304-4165(97)00125-6
   NELSON R, 1978, SOUTHERN MED J, V71, P1482, DOI 10.1097/00007611-197812000-00011
   Nemeth E, 2005, BLOOD, V105, P1803, DOI 10.1182/blood-2004-08-3042
   Nemeth E, 2004, SCIENCE, V306, P2090, DOI 10.1126/science.1104742
   Özdemir A, 2007, AM J MED SCI, V334, P331, DOI 10.1097/MAJ.0b013e318145b107
   Pietrangelo A, 2010, GASTROENTEROLOGY, V139, P393, DOI 10.1053/j.gastro.2010.06.013
   Pinhas-Hamiel O, 2003, INT J OBESITY, V27, P416, DOI 10.1038/sj.ijo.0802224
   Ponugoti B, 2012, EXP DIABETES RES, DOI 10.1155/2012/939751
   Qi L, 2007, DIABETES CARE, V30, P101, DOI 10.2337/dc06-1686
   Qiu CF, 2011, DIABETES CARE, V34, P1564, DOI 10.2337/dc11-0135
   Radisky DC, 1999, J BIOL CHEM, V274, P4497, DOI 10.1074/jbc.274.8.4497
   Ravelli ACJ, 1998, LANCET, V351, P173, DOI 10.1016/S0140-6736(97)07244-9
   Ray PD, 2012, CELL SIGNAL, V24, P981, DOI 10.1016/j.cellsig.2012.01.008
   Regazzetti C, 2009, DIABETES, V58, P95, DOI 10.2337/db08-0457
   Romney SJ, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002394
   ROSSETTI L, 1990, DIABETES CARE, V13, P610, DOI 10.2337/diacare.13.6.610
   Rouault TA, 2009, CELL METAB, V10, P80, DOI 10.1016/j.cmet.2009.07.007
   Rumberger JM, 2004, DIABETES, V53, P2535, DOI 10.2337/diabetes.53.10.2535
   Semenza GL, 2012, CELL, V148, P399, DOI 10.1016/j.cell.2012.01.021
   Shah YM, 2009, CELL METAB, V9, P152, DOI 10.1016/j.cmet.2008.12.012
   Shakoury-Elizeh M, 2010, J BIOL CHEM, V285, P14823, DOI 10.1074/jbc.M109.091710
   Sharifi F, 2008, DIABETES VASC DIS RE, V5, P15, DOI 10.3132/dvdr.2008.003
   Shayeghi M, 2005, CELL, V122, P789, DOI 10.1016/j.cell.2005.06.025
   Sonnweber T, 2012, J NUTR BIOCHEM, V23, P1600, DOI 10.1016/j.jnutbio.2011.10.013
   Stangl GI, 1998, LIPIDS, V33, P889, DOI 10.1007/s11745-998-0285-8
   Subauste AR, 2007, AM J PHYSIOL-ENDOC M, V293, pE159, DOI 10.1152/ajpendo.00629.2006
   Takeuchi T, 2006, DEV DYNAM, V235, P2449, DOI 10.1002/dvdy.20851
   TANNER LI, 1987, J BIOL CHEM, V262, P8975
   Toomajian C, 2003, GENETICS, V165, P287
   Tormos KV, 2011, CELL METAB, V14, P537, DOI 10.1016/j.cmet.2011.08.007
   Trayhurn P, 2005, BIOCHEM SOC T, V33, P1078, DOI [10.1042/BST0331078, 10.1042/BST20051078]
   Tuomainen TP, 1997, DIABETES CARE, V20, P426, DOI 10.2337/diacare.20.3.426
   Vogiatzi MG, 2009, BRIT J HAEMATOL, V146, P546, DOI 10.1111/j.1365-2141.2009.07793.x
   Walter PB, 2002, P NATL ACAD SCI USA, V99, P2264, DOI 10.1073/pnas.261708798
   Wang RH, 2005, CELL METAB, V2, P399, DOI 10.1016/j.cmet.2005.10.010
   Weatherall DJ, 1998, BAILLIERE CLIN HAEM, V11, P127, DOI 10.1016/S0950-3536(98)80072-3
   Wiley SE, 2007, P NATL ACAD SCI USA, V104, P5318, DOI 10.1073/pnas.0701078104
   Wilson JG, 2003, AM J MED SCI, V325, P332, DOI 10.1097/00000441-200306000-00004
   Wlazlo N, 2013, DIABETES CARE, V36, P309, DOI 10.2337/dc12-0505
   Yamagishi H, 2000, J NUTR BIOCHEM, V11, P455, DOI 10.1016/S0955-2863(00)00113-3
   Yanoff LB, 2007, INT J OBESITY, V31, P1412, DOI 10.1038/sj.ijo.0803625
   Yin L, 2007, SCIENCE, V318, P1786, DOI 10.1126/science.1150179
   Zehetner J, 2008, GENE DEV, V22, P3135, DOI 10.1101/gad.496908
   Zuris JA, 2012, J BIOL CHEM, V287, P11649, DOI 10.1074/jbc.M111.319731
   Zuris JA, 2011, P NATL ACAD SCI USA, V108, P13047, DOI 10.1073/pnas.1109986108
NR 161
TC 403
Z9 440
U1 2
U2 51
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD MAR 5
PY 2013
VL 17
IS 3
BP 329
EP 341
DI 10.1016/j.cmet.2013.02.007
PG 13
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 242TP
UT WOS:000326265400006
PM 23473030
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Tabas, I
   Tall, A
   Accili, D
AF Tabas, Ira
   Tall, Alan
   Accili, Domenico
TI The Impact of Macrophage Insulin Resistance on Advanced Atherosclerotic
   Plaque Progression
SO CIRCULATION RESEARCH
LA English
DT Review
DE atherosclerosis; insulin resistance; diabetes; macrophages; apoptosis
ID ENDOPLASMIC-RETICULUM STRESS; CARDIOVASCULAR RISK-FACTORS; UNFOLDED
   PROTEIN RESPONSE; FOAM CELL-FORMATION; APOPTOTIC CELLS;
   DIABETES-MELLITUS; NECROTIC CORE; FATTY-ACIDS; LIPID CORE; CHOLESTEROL
AB Atherothrombotic vascular disease is the major cause of death and disability in obese and diabetic subjects with insulin resistance. Although increased systemic risk factors in the setting of insulin resistance contribute to this problem, it is likely exacerbated by direct effects of insulin resistance on the arterial wall cells that participate in atherosclerosis. A critical process in the progression of subclinical atherosclerotic lesions to clinically relevant lesions is necrotic breakdown of plaques. Plaque necrosis, which is particularly prominent in the lesions of diabetics, is caused by the combination of macrophage apoptosis and defective phagocytic clearance, or efferocytosis, of the apoptotic macrophages. One cause of macrophage apoptosis in advanced plaques is activation of a proapoptotic branch of the unfolded protein response, which is an endoplasmic reticulum stress pathway. Macrophages have a functional insulin receptor signaling pathway, and downregulation of this pathway in the setting insulin resistance enhances unfolded protein response-induced apoptosis. Moreover, other aspects of the obesity/insulin-resistance syndrome may adversely affect efferocytosis. These processes may therefore provide an important mechanistic link among insulin resistance, plaque necrosis, and atherothrombotic vascular disease and suggest novel therapeutic approaches to this expanding health problem. (Circ Res. 2010;106:58-67.)
C1 [Tabas, Ira; Tall, Alan; Accili, Domenico] Columbia Univ, Dept Med, New York, NY 10032 USA.
   [Tabas, Ira; Tall, Alan] Columbia Univ, Dept Physiol & Cellular Biophys, New York, NY 10032 USA.
   [Tabas, Ira] Columbia Univ, Dept Pathol & Cell Biol, New York, NY 10032 USA.
C3 Columbia University; Columbia University; Columbia University
RP Tabas, I (corresponding author), Columbia Univ, Dept Med, 630 W 168th St, New York, NY 10032 USA.
EM iat1@columbia.edu
RI Tall, Alan/AAT-8528-2021; Stefanadis, Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454; Tabas,
   Ira/0000-0003-3429-1515
FU NIH [HL087123, HL075662, HL054591]; US Army Medical Research and
   Materiel Command (USAMRMC) [W81XWH-06-1-0212]
FX This work was supported by NIH grants HL087123, HL075662, and HL054591
   and US Army Medical Research and Materiel Command (USAMRMC) grant
   W81XWH-06-1-0212.
CR Aikawa M, 2004, CARDIOVASC PATHOL, V13, P125, DOI 10.1016/S1054-8807(04)00004-3
   Aprahamian T, 2008, CLIN EXP IMMUNOL, V152, P448, DOI 10.1111/j.1365-2249.2008.03658.x
   Balch WE, 2008, SCIENCE, V319, P916, DOI 10.1126/science.1141448
   BALL RY, 1995, ATHEROSCLEROSIS, V114, P45, DOI 10.1016/0021-9150(94)05463-S
   Barker DJP, 2005, NEW ENGL J MED, V353, P1802, DOI 10.1056/NEJMoa044160
   Baumgartl J, 2006, CELL METAB, V3, P247, DOI 10.1016/j.cmet.2006.02.010
   Beg AA, 1996, SCIENCE, V274, P782, DOI 10.1126/science.274.5288.782
   Burke Allen P., 2003, Journal of the American College of Cardiology, V41, P1874, DOI 10.1016/S0735-1097(03)00359-0
   Burke AP, 2004, ARTERIOSCL THROM VAS, V24, P1266, DOI 10.1161/01.ATV.0000131783.74034.97
   CALDER PC, 1990, BIOCHEM J, V269, P807, DOI 10.1042/bj2690807
   Chang MK, 1999, P NATL ACAD SCI USA, V96, P6353, DOI 10.1073/pnas.96.11.6353
   Chen XL, 2004, CURR PHARM DESIGN, V10, P879, DOI 10.2174/1381612043452901
   Collins AR, 2009, CIRC RES, V104, pe42, DOI 10.1161/CIRCRESAHA.108.188771
   D'Souza A, 2009, MOL CELL BIOCHEM, V331, P89, DOI 10.1007/s11010-009-0148-8
   DeVries-Seimon T, 2005, J CELL BIOL, V171, P61, DOI 10.1083/jcb.200502078
   ENDEMANN G, 1993, J BIOL CHEM, V268, P11811
   Fadok VA, 2001, J CLIN INVEST, V108, P957, DOI 10.1172/JCI14122
   Fadok VA, 2001, J IMMUNOL, V166, P6847, DOI 10.4049/jimmunol.166.11.6847
   Feng B, 2003, P NATL ACAD SCI USA, V100, P10423, DOI 10.1073/pnas.1732494100
   Feng B, 2003, NAT CELL BIOL, V5, P781, DOI 10.1038/ncb1035
   Fernández-Hernando C, 2007, CELL METAB, V6, P446, DOI 10.1016/j.cmet.2007.10.007
   Fox CS, 2007, CIRCULATION, V115, P1544, DOI 10.1161/CIRCULATIONAHA.106.658948
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   García-García HM, 2009, JACC-CARDIOVASC IMAG, V2, P629, DOI 10.1016/j.jcmg.2009.01.008
   Gargalovic PS, 2006, ARTERIOSCL THROM VAS, V26, P2490, DOI 10.1161/01.ATV.0000242903.41158.a1
   Gautier EL, 2009, CIRCULATION, V119, P1795, DOI 10.1161/CIRCULATIONAHA.108.806158
   Glass CK, 2001, CELL, V104, P503, DOI 10.1016/S0092-8674(01)00238-0
   Grundy SM, 2004, J CLIN ENDOCR METAB, V89, P2595, DOI 10.1210/jc.2004-0372
   GUYTON JR, 1994, ARTERIOSCLER THROMB, V14, P1305, DOI 10.1161/01.ATV.14.8.1305
   Haffner SM, 1999, DIABETES CARE, V22, P562, DOI 10.2337/diacare.22.4.562
   Hall MO, 2003, ADV EXP MED BIOL, V533, P331
   Han S, 2006, CELL METAB, V3, P257, DOI 10.1016/j.cmet.2006.02.008
   Han S, 2009, J CLIN INVEST, V119, P1029, DOI 10.1172/JCI36523
   Harja E, 2008, J CLIN INVEST, V118, P183, DOI 10.1172/JCI32703
   Hegyi L, 1996, J PATHOL, V180, P423, DOI 10.1002/(SICI)1096-9896(199612)180:4<423::AID-PATH677>3.0.CO;2-1
   Hong YJ, 2009, JACC-CARDIOVASC IMAG, V2, P339, DOI 10.1016/j.jcmg.2008.10.017
   Hu B, 2002, J LEUKOCYTE BIOL, V71, P881
   ITOUFELLA H, 2008, ARTERIOSCLER THROMB, V28, P1429
   Johansson F, 2008, P NATL ACAD SCI USA, V105, P2082, DOI 10.1073/pnas.0709958105
   KATZ S S, 1976, Journal of Clinical Investigation, V58, P200
   KHAN MI, ANTIOXID RE IN PRESS
   Kolodgie FD, 2004, HEART, V90, P1385, DOI 10.1136/hrt.2004.041798
   KRUTH HS, 1984, AM J PATHOL, V114, P201
   Leaf A, 2008, AM J CLIN NUTR, V87, p1978S, DOI 10.1093/ajcn/87.6.1978S
   Li G, 2009, J CELL BIOL, V186, P783, DOI 10.1083/jcb.200904060
   LI S, CIRC RES IN PRESS
   Li YK, 2005, J BIOL CHEM, V280, P21763, DOI 10.1074/jbc.M501759200
   Li YK, 2004, J BIOL CHEM, V279, P37030, DOI 10.1074/jbc.M405195200
   Liang C, 2008, DIABETES, V57, pA198
   Liang CP, 2007, CIRC RES, V100, P1546, DOI 10.1161/CIRCRESAHA.107.152165
   Liang CP, 2004, J CLIN INVEST, V113, P764, DOI [10.1172/JCI200419528, 10.1172/JCI19528]
   Libby Peter, 1993, Current Opinion in Lipidology, V4, P355, DOI 10.1097/00041433-199310000-00003
   Lim WS, 2008, CIRCULATION, V117, P940, DOI 10.1161/CIRCULATIONAHA.107.711275
   LUNDBERG B, 1985, ATHEROSCLEROSIS, V56, P93, DOI 10.1016/0021-9150(85)90087-5
   Lusis AJ, 2000, NATURE, V407, P233, DOI 10.1038/35025203
   Manning-Tobin JJ, 2009, ARTERIOSCL THROM VAS, V29, P19, DOI 10.1161/ATVBAHA.108.176644
   Mitchell S, 2002, J AM SOC NEPHROL, V13, P2497, DOI 10.1097/01.ASN.0000032417.73640.72
   Moreno PR, 2000, CIRCULATION, V102, P2180
   Myoishi M, 2007, CIRCULATION, V116, P1226, DOI 10.1161/CIRCULATIONAHA.106.682054
   Naghavi M, 2003, CIRCULATION, V108, P1664, DOI 10.1161/01.CIR.0000087480.94275.97
   Naidoo N, 2009, REV NEUROSCIENCE, V20, P23
   Nakae J, 1999, J BIOL CHEM, V274, P15982, DOI 10.1074/jbc.274.23.15982
   Nasu K, 2008, HEART, V94, P429, DOI 10.1136/hrt.2007.118950
   Nishikawa T, 2000, NATURE, V404, P787, DOI 10.1038/35008121
   Oh J, 2009, CIRCULATION, V120, P687, DOI 10.1161/CIRCULATIONAHA.109.856070
   Ohayon J, 2008, AM J PHYSIOL-HEART C, V295, pH717, DOI 10.1152/ajpheart.00005.2008
   Pedruzzi E, 2004, MOL CELL BIOL, V24, P10703, DOI 10.1128/MCB.24.24.10703-10717.2004
   Plutzky J, 2002, J DIABETES COMPLICAT, V16, P401, DOI 10.1016/S1056-8727(02)00202-7
   Preis SR, 2009, CIRCULATION, V120, P212, DOI 10.1161/CIRCULATIONAHA.108.846519
   Pundziute G, 2009, J NUCL CARDIOL, V16, P376, DOI 10.1007/s12350-008-9046-9
   Reaven PD, 2009, DIABETES, V58, P2642, DOI 10.2337/db09-0618
   Rosenfeld Michael E, 2002, Curr Atheroscler Rep, V4, P238, DOI 10.1007/s11883-002-0025-3
   ROSS R, 1995, ANNU REV PHYSIOL, V57, P791, DOI 10.1146/annurev.ph.57.030195.004043
   Sanson M, 2009, CIRC RES, V104, P328, DOI 10.1161/CIRCRESAHA.108.183749
   Sather S, 2007, BLOOD, V109, P1026, DOI 10.1182/blood-2006-05-021634
   Schaefer H E, 1981, Haematol Blood Transfus, V27, P137
   Schindler JF, 2007, J DENT RES, V86, P800, DOI 10.1177/154405910708600902
   Schrijvers DM, 2005, ARTERIOSCL THROM VAS, V25, P1256, DOI 10.1161/01.ATV.0000166517.18801.a7
   Secchiero P, 2006, CIRCULATION, V114, P1522, DOI 10.1161/CIRCULATIONAHA.106.643841
   Seimon TA, 2006, P NATL ACAD SCI USA, V103, P19794, DOI 10.1073/pnas.0609671104
   Seimon TA, 2009, J CLIN INVEST, V119, P886, DOI 10.1172/JCI37262
   Senokuchi T, 2008, DIABETES, V57, P2967, DOI 10.2337/db08-0520
   Serhan CN, 2008, NAT REV IMMUNOL, V8, P349, DOI 10.1038/nri2294
   SHIO H, 1979, LAB INVEST, V41, P160
   Silvera SS, 2009, ATHEROSCLEROSIS, V207, P139, DOI 10.1016/j.atherosclerosis.2009.04.023
   SMALL DM, 1988, ARTERIOSCLEROSIS, V8, P103, DOI 10.1161/01.ATV.8.2.103
   Tabas I, 2005, ARTERIOSCL THROM VAS, V25, P2255, DOI 10.1161/01.ATV.0000184783.04864.9f
   Tabas I, 2004, CELL DEATH DIFFER, V11, pS12, DOI 10.1038/sj.cdd.4401444
   TABAS I, 2010, NATURE REV IN PRESS
   Tabas I, 2007, CIRCULATION, V116, P1832, DOI 10.1161/CIRCULATIONAHA.106.676890
   Tanaka J, 2009, DIABETES, V58, P2344, DOI 10.2337/db09-0167
   THORP E, 2009, J LEUKOCYTE BIOL
   Thorp E, 2008, ARTERIOSCL THROM VAS, V28, P1421, DOI 10.1161/ATVBAHA.108.167197
   Thorp E, 2007, CIRCULATION, V116, P2182, DOI 10.1161/CIRCULATIONAHA.107.698852
   Thorp E, 2009, CELL METAB, V9, P474, DOI 10.1016/j.cmet.2009.03.003
   Timmins JM, 2009, J CLIN INVEST, V119, P2925, DOI 10.1172/JCI38857
   Virmani Renu, 2002, J Interv Cardiol, V15, P439, DOI 10.1111/j.1540-8183.2002.tb01087.x
   Wickline SA, 2007, J MAGN RESON IMAGING, V25, P667, DOI 10.1002/jmri.20866
   Williams KJ, 2005, CURR OPIN CLIN NUTR, V8, P139, DOI 10.1097/00075197-200503000-00006
   Wilson PWF, 1998, CIRCULATION, V97, P1837, DOI 10.1161/01.CIR.97.18.1837
   Yach D, 2006, NAT MED, V12, P62, DOI 10.1038/nm0106-62
   Yao PM, 2000, J BIOL CHEM, V275, P23807, DOI 10.1074/jbc.M002087200
   Yao PM, 2001, J BIOL CHEM, V276, P42468, DOI 10.1074/jbc.M101419200
   Young JL, 2002, THROMB HAEMOSTASIS, V88, P554, DOI 10.1055/s-0037-1613256
   Yu JJ, 2008, CURR VASC PHARMACOL, V6, P204, DOI 10.2174/157016108784911984
   Zhang R, 2005, NAT MED, V11, P409, DOI 10.1038/nm1215
   Zhou J, 2005, CIRCULATION, V111, P1814, DOI 10.1161/01.CIR.0000160864.31351.C1
NR 107
TC 96
Z9 104
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7330
EI 1524-4571
J9 CIRC RES
JI Circ.Res.
PD JAN 8
PY 2010
VL 106
IS 1
BP 58
EP 67
DI 10.1161/CIRCRESAHA.109.208488
PG 10
WC Cardiac & Cardiovascular Systems; Hematology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Hematology
GA 541GP
UT WOS:000273403600013
PM 20056946
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Singh, MK
   Leslie, SM
   Packer, MM
   Zaiko, YV
   Phillips, OR
   Weisman, EF
   Wall, DM
   Jo, B
   Rasgon, N
AF Singh, Manpreet K.
   Leslie, Sara M.
   Packer, Mary Melissa
   Zaiko, Yevgeniya V.
   Phillips, Owen R.
   Weisman, Elizabeth F.
   Wall, Danielle M.
   Jo, Booil
   Rasgon, Natalie
TI Brain and behavioral correlates of insulin resistance in youth with
   depression and obesity
SO HORMONES AND BEHAVIOR
LA English
DT Article
DE Pediatric depression; Obesity; Insulin resistance; Resting state
   functional connectivity; Neural structure
ID STATE FUNCTIONAL CONNECTIVITY; 3-FACTOR EATING QUESTIONNAIRE; METABOLIC
   SYNDROME; CONSTRUCT-VALIDITY; PHYSICAL-ACTIVITY; MAJOR DEPRESSION;
   CEREBRAL-CORTEX; GRAY-MATTER; REWARD; ADOLESCENTS
AB Depression, together with insulin resistance, is increasingly prevalent among youth. These conditions have traditionally been compartmentalized, but recent evidence suggests that a shared brain motivational network underlies their co-occurrence. We posit that, in the context of depressive symptoms, insulin resistance is associated with aberrant structure and functional connectivity in the Anterior Cingulate Cortex (ACC) and hippocampus. This motivational neural circuit underlies dysfunctional behavioral responses and increased sensitivity to rewarding aspects of ingesting high calorie food that lead to disinhibition of eating even when satiated. To investigate this shared mechanism, we evaluated a sample of forty-two depressed and overweight (BMI > 85th %) youth aged 9 to 17. Using ACC and hippocampus structural and seed-based regions of interest, we investigated associations between insulin resistance, depression, structure (ACC thickness, and ACC and hippocampal area), and resting-state functional connectivity (RSFC). We predicted that aberrant associations among these neural and behavioral characteristics would be stronger in insulin resistant compared to insulin sensitive youth. We found that youth with greater insulin resistance had higher levels of anhedonia and more food seeking behaviors, reduced hippocampal and ACC volumes, and greater levels of ACC and hippocampal dysconnectivity to fronto-limbic reward networks at rest. For youth with high levels of insulin resistance, thinner ACC and smaller hippocampal volumes were associated with more severe depressive symptoms, whereas the opposite was true for youth with low levels of insulin resistance. The ACC-hippocampal motivational network that subserves depression and insulin resistance separately, may represent a critical neural interaction that link these syndromes together.
C1 [Singh, Manpreet K.; Leslie, Sara M.; Packer, Mary Melissa; Zaiko, Yevgeniya V.; Phillips, Owen R.; Weisman, Elizabeth F.; Wall, Danielle M.; Jo, Booil; Rasgon, Natalie] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
C3 Stanford University
RP Singh, MK (corresponding author), Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
EM mksingh@stanford.edu
RI Rasgon, Natalie/ABH-9813-2020; phillips, owen/J-3651-2017; Singh,
   Manpreet/L-1068-2014
OI Leslie, Sara/0000-0002-5557-4293; Singh, Manpreet/0000-0002-4373-3293;
   Packer West, Melissa/0000-0001-7161-5860
FU National Institute of Mental Health [R01MH106581]
FX This work was supported by the National Institute of Mental Health
   (R01MH106581). We would like to express appreciation to our research
   participants and families and members of our Pediatric Emotion And
   Resilience Lab (PEARL) for their contributions to this work.
CR Adam TC, 2015, PEDIATR OBES, V10, P30, DOI 10.1111/j.2047-6310.2013.00210.x
   Akin O, 2017, J PEDIATR ENDOCR MET, V30, P1027, DOI 10.1515/jpem-2017-0186
   Al Mamun A, 2007, OBESITY, V15, P3097, DOI 10.1038/oby.2007.369
   Androutsos O, 2014, EUR J CLIN NUTR, V68, P344, DOI 10.1038/ejcn.2013.280
   [Anonymous], 1999, WECHSLER ABBREVIATED
   Anthony K, 2006, DIABETES, V55, P2986, DOI 10.2337/db06-0376
   Argyelan M, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.54
   Austin AW, 2014, DIABETIC MED, V31, P994, DOI 10.1111/dme.12465
   Bauer CCC, 2015, PEDIATR OBES, V10, P196, DOI 10.1111/ijpo.241
   Beydoun MA, 2016, J NUTR, V146, P1241, DOI 10.3945/jn.115.229054
   Black JM, 2012, NEUROIMAGE, V59, P3021, DOI 10.1016/j.neuroimage.2011.10.024
   Brambilla P, 2007, INT J OBESITY, V31, P591, DOI 10.1038/sj.ijo.0803581
   Brown ES, 2004, BIOL PSYCHIAT, V55, P1, DOI 10.1016/S0006-3223(03)00473-6
   Buhl ES, 2010, AM J PHYSIOL-ENDOC M, V298, pE920, DOI 10.1152/ajpendo.00606.2009
   Carter J, 2016, PSYCHONEUROENDOCRINO, V69, P123, DOI 10.1016/j.psyneuen.2016.04.002
   Castro MG, 2016, OBESITY, V24, P1283, DOI 10.1002/oby.21500
   Chantiluke K, 2012, BIOL PSYCHIAT, V71, P59, DOI 10.1016/j.biopsych.2011.09.005
   Charmandari E, 2003, HORM RES, V59, P161, DOI 10.1159/000069325
   Christensen L, 2001, APPETITE, V36, P137, DOI 10.1006/appe.2001.0390
   de Kwaasteniet B, 2013, BIOL PSYCHIAT, V74, P40, DOI 10.1016/j.biopsych.2012.12.024
   de la Torre-Luque A, 2016, NEUROSCI BIOBEHAV R, V68, P410, DOI 10.1016/j.neubiorev.2016.05.023
   Eisenstein SA, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0133621
   Ernersson Å, 2010, EAT BEHAV, V11, P247, DOI 10.1016/j.eatbeh.2010.05.005
   Ewing SWF, 2017, BRAIN IMAGING BEHAV, V11, P925, DOI 10.1007/s11682-016-9564-z
   Figlewicz DP, 2016, BRAIN RES, V1645, P68, DOI 10.1016/j.brainres.2015.12.041
   Fischl B, 2000, P NATL ACAD SCI USA, V97, P11050, DOI 10.1073/pnas.200033797
   Foland-Ross LC, 2015, INT J DEV NEUROSCI, V46, P125, DOI 10.1016/j.ijdevneu.2015.07.007
   Gabbay V, 2013, J AM ACAD CHILD PSY, V52, P628, DOI 10.1016/j.jaac.2013.04.003
   Gallant AR, 2010, BRIT J NUTR, V104, P1074, DOI 10.1017/S0007114510001662
   Gelman A, 2009, AM STAT, V63, P1, DOI 10.1198/tast.2009.0001
   Goldfield GS, 2010, J SCHOOL HEALTH, V80, P186, DOI 10.1111/j.1746-1561.2009.00485.x
   Gradin VB, 2011, BRAIN, V134, P1751, DOI 10.1093/brain/awr059
   Gunnell KE, 2016, PREV MED, V88, P147, DOI 10.1016/j.ypmed.2016.04.002
   Hallschmid M, 2009, DIABETOLOGIA, V52, P2264, DOI 10.1007/s00125-009-1501-x
   Hamilton JP, 2011, MOL PSYCHIATR, V16, P763, DOI 10.1038/mp.2010.46
   Hawker DSJ, 2000, J CHILD PSYCHOL PSYC, V41, P441, DOI 10.1111/1469-7610.00629
   Hermens DF, 2018, EUR ARCH PSY CLIN N, V268, P145, DOI 10.1007/s00406-017-0788-8
   Hiles SA, 2016, DEPRESS ANXIETY, V33, P754, DOI 10.1002/da.22512
   Hills AP, 2007, SPORTS MED, V37, P533, DOI 10.2165/00007256-200737060-00006
   Ho PM, 2015, J PERS ASSESS, V97, P200, DOI 10.1080/00223891.2014.940625
   Hulvershorn LA, 2011, BRAIN IMAGING BEHAV, V5, P307, DOI 10.1007/s11682-011-9134-3
   Huys QJM, 2013, BIOL MOOD ANXIETY DI, V3, DOI 10.1186/2045-5380-3-12
   Jalbrzikowski M, 2017, BIOL PSYCHIAT, V82, P511, DOI 10.1016/j.biopsych.2017.01.008
   James GM, 2017, FRONT HUM NEUROSCI, V11, DOI 10.3389/fnhum.2017.00048
   Jani BD, 2014, BMC CARDIOVASC DISOR, V14, DOI 10.1186/1471-2261-14-139
   Jenkinson M, 2002, NEUROIMAGE, V17, P825, DOI 10.1006/nimg.2002.1132
   Kaufman J, 1997, J AM ACAD CHILD PSY, V36, P980, DOI 10.1097/00004583-199707000-00021
   Keding TJ, 2015, NEUROPSYCHOPHARMACOL, V40, P537, DOI 10.1038/npp.2014.239
   Kenna H, 2013, NEUROBIOL AGING, V34, P641, DOI 10.1016/j.neurobiolaging.2012.06.006
   Khanh DV, 2014, FRONT PSYCHOL, V5, DOI 10.3389/fpsyg.2014.00846
   Kullmann S, 2012, HUM BRAIN MAPP, V33, P1052, DOI 10.1002/hbm.21268
   Kumar P, 2008, BRAIN, V131, P2084, DOI 10.1093/brain/awn136
   Lamers F, 2016, BRIT J PSYCHIAT, V208, P62, DOI 10.1192/bjp.bp.114.153098
   Lamers F, 2010, J CLIN PSYCHIAT, V71, P1582, DOI 10.4088/JCP.09m05398blu
   Lichenstein SD, 2016, NEUROSCI BIOBEHAV R, V70, P271, DOI 10.1016/j.neubiorev.2016.07.024
   Lips MA, 2014, AM J CLIN NUTR, V100, P524, DOI 10.3945/ajcn.113.080671
   Liu CS, 2014, CNS NEUROL DISORD-DR, V13, P1693
   MacMaster FP, 2008, BIOL PSYCHIAT, V63, P385, DOI 10.1016/j.biopsych.2007.05.005
   Marusak HA, 2017, BIOL PSYCHIAT-COGN N, V2, P130, DOI 10.1016/j.bpsc.2016.11.002
   Matsuda M, 1999, DIABETES CARE, V22, P1462, DOI 10.2337/diacare.22.9.1462
   Mazaika PK, 2016, DIABETES, V65, P476, DOI 10.2337/db15-1242
   McElroy SL, 2004, J CLIN PSYCHIAT, V65, P634
   McIntyre RS, 2015, CNS DRUGS, V29, P577, DOI 10.1007/s40263-015-0263-x
   McIntyre RS, 2010, ADV THER, V27, P63, DOI 10.1007/s12325-010-0011-z
   McIntyre RS, 2009, CURR DIABETES REP, V9, P51, DOI 10.1007/s11892-009-0010-0
   Melasch J, 2016, INT J OBESITY, V40, P779, DOI 10.1038/ijo.2015.216
   Merikangas KR, 2010, J AM ACAD CHILD PSY, V49, P980, DOI 10.1016/j.jaac.2010.05.017
   Muthen B. O., 1998, MPLUS USERS GUIDE
   Neef M, 2013, BEST PRACT RES CL EN, V27, P229, DOI 10.1016/j.beem.2013.02.007
   Nemiary D, 2012, PSYCHIAT ANN, V42, P305, DOI 10.3928/00485713-20120806-09
   Nusslock R, 2017, J AFFECT DISORDERS, V216, P3, DOI 10.1016/j.jad.2017.02.001
   Olive LS, 2017, HEALTH PSYCHOL, V36, P749, DOI 10.1037/hea0000496
   Page KA, 2013, JAMA-J AM MED ASSOC, V309, P63, DOI 10.1001/jama.2012.116975
   Pannekoek JN, 2014, NEUROIMAGE-CLIN, V4, P336, DOI 10.1016/j.nicl.2014.01.007
   Pearson S, 2010, DIABETES CARE, V33, P1128, DOI 10.2337/dc09-1940
   Penninx BWJH, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-129
   Pervanidou P, 2012, METABOLISM, V61, P611, DOI 10.1016/j.metabol.2011.10.005
   Pliquett RU, 2006, HORM METAB RES, V38, P442, DOI 10.1055/s-2006-947840
   Pott W, 2010, J DEV BEHAV PEDIATR, V31, P635, DOI 10.1097/DBP.0b013e3181f178eb
   Power JD, 2014, NEUROIMAGE, V84, P320, DOI 10.1016/j.neuroimage.2013.08.048
   POZNANSKI EO, 1984, J AM ACAD CHILD PSY, V23, P191, DOI 10.1097/00004583-198403000-00011
   Pruessner JC, 2010, PSYCHONEUROENDOCRINO, V35, P179, DOI 10.1016/j.psyneuen.2009.02.016
   Raji CA, 2010, HUM BRAIN MAPP, V31, P353, DOI 10.1002/hbm.20870
   Ramasubbu R, 2002, MED HYPOTHESES, V59, P537, DOI 10.1016/S0306-9877(02)00244-X
   Rasgon NL, 2016, MOL PSYCHIATR, V21, P1648, DOI 10.1038/mp.2016.162
   Rasgon Natalie L, 2005, Neurobiol Aging, V26 Suppl 1, P103, DOI 10.1016/j.neurobiolaging.2005.09.004
   Rasgon NL, 2011, NEUROBIOL AGING, V32, P1942, DOI 10.1016/j.neurobiolaging.2009.12.005
   Rasgon NL, 2010, THESCIENTIFICWORLDJO, V10, P321, DOI 10.1100/tsw.2010.32
   Ryan JP, 2012, PSYCHOSOM MED, V74, P476, DOI 10.1097/PSY.0b013e31824d0865
   Rzepa E, 2016, J PSYCHIATR RES, V82, P40, DOI 10.1016/j.jpsychires.2016.07.013
   Salat DH, 2004, CEREB CORTEX, V14, P721, DOI 10.1093/cercor/bhh032
   Schmaal L, 2017, J AM ACAD CHILD PSY, V56, P593, DOI 10.1016/j.jaac.2017.05.008
   SHEARIN EN, 1994, INT J EAT DISORDER, V16, P187, DOI 10.1002/1098-108X(199409)16:2<187::AID-EAT2260160210>3.0.CO;2-U
   Shomaker LB, 2011, DIABETES CARE, V34, P2458, DOI 10.2337/dc11-1131
   Singh MK, 2014, JAMA PSYCHIAT, V71, P1148, DOI 10.1001/jamapsychiatry.2014.1031
   Singh MK, 2013, J AM ACAD CHILD PSY, V52, P68, DOI 10.1016/j.jaac.2012.10.004
   Singh M, 2014, FRONT PSYCHOL, V5, DOI 10.3389/fpsyg.2014.00925
   Smith SM, 2002, HUM BRAIN MAPP, V17, P143, DOI 10.1002/hbm.10062
   SNAITH RP, 1995, BRIT J PSYCHIAT, V167, P99, DOI 10.1192/bjp.167.1.99
   Soczynska JK, 2011, NEUROMOL MED, V13, P93, DOI 10.1007/s12017-010-8140-8
   Somerset SM, 2011, CLIN NUTR, V30, P593, DOI 10.1016/j.clnu.2011.04.004
   Stouffer MA, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms9543
   Takeuchi T, 2013, PSYCHIAT CLIN NEUROS, V67, P532, DOI 10.1111/pcn.12104
   Teh MM, 2010, NEUROIMAGE, V53, P584, DOI 10.1016/j.neuroimage.2010.06.033
   van der Aa MP, 2017, J PEDIATR ENDOCR MET, V30, P123, DOI 10.1515/jpem-2016-0242
   van Dijk AE, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-251
   Wang HF, 2017, SCI REP-UK, V7, DOI 10.1038/srep40595
   Weltens N, 2014, NEUROGASTROENT MOTIL, V26, P303, DOI 10.1111/nmo.12309
   Williams DB, 2015, J RECEPT SIG TRANSD, V35, P516, DOI 10.3109/10799893.2014.960935
   Wolkowitz Owen M, 2011, Dialogues Clin Neurosci, V13, P25
   Wong JJ, 2016, PEERJ, V4, DOI 10.7717/peerj.1710
   Wozniak J, 2012, ISR J PSYCHIATR REL, V49, P62
   Yates KF, 2012, ARTERIOSCL THROM VAS, V32, P2060, DOI 10.1161/ATVBAHA.112.252759
   Yau PL, 2014, OBESITY, V22, P1865, DOI 10.1002/oby.20801
   Yau PL, 2012, PEDIATRICS, V130, pE856, DOI 10.1542/peds.2012-0324
   Ye M, 2016, BMC PSYCHIATRY, V16, DOI 10.1186/s12888-016-1053-9
   Young JJ, 2016, FRONT PSYCHIATRY, V7, DOI 10.3389/fpsyt.2016.00072
   Zeng LL, 2012, BRAIN, V135, P1498, DOI 10.1093/brain/aws059
NR 118
TC 50
Z9 51
U1 1
U2 29
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0018-506X
EI 1095-6867
J9 HORM BEHAV
JI Horm. Behav.
PD FEB
PY 2019
VL 108
BP 73
EP 83
DI 10.1016/j.yhbeh.2018.03.009
PG 11
WC Behavioral Sciences; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Endocrinology & Metabolism
GA HN4YH
UT WOS:000460189100008
PM 29596854
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Khassawneh, AH
   Alzoubi, A
   Khasawneh, AG
   Abdo, N
   Abu-Naser, D
   Al-Mistarehi, AH
   Albattah, MF
   Kheirallah, KA
AF Khassawneh, Adi H.
   Alzoubi, Abdallah
   Khasawneh, Aws G.
   Abdo, Nour
   Abu-Naser, Dania
   Al-Mistarehi, Abdel-Hameed
   Albattah, Malak F.
   Kheirallah, Khalid A.
TI The relationship between depression and metabolic control parameters in
   type 2 diabetic patients: A cross-sectional and feasibility
   interventional study
SO INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
LA English
DT Article
ID COMORBID DEPRESSION; AFRICAN-AMERICANS; PREVALENCE; HEALTH; SYMPTOMS;
   MELLITUS; ADULTS; METAANALYSIS; INDIVIDUALS; RISK
AB Background Substantial evidence supports a bidirectional relationship between diabetes and clinical depression. However, little is known about the effect of treating one condition on the control of the other. Thus, this study aimed to determine the prevalence of depression among Type II diabetes mellitus (T2DM) patients and to assess the efficacy and feasibility of escitalopram treatment of depression on their metabolic control parameters.
   Methods T2DM patients attending primary care clinics in the North of Jordan were enrolled in a cross-sectional study during the period from February to December 2019 (n = 157). Depressive symptoms were screened utilising the patient health questionnaire-9 (PHQ-9) tool. Metabolic control was assessed by measurement of glycated haemoglobin (HbA1c), triglycerides, cholesterol, low-density lipoprotein (LDL) and high-density lipoprotein (HDL). Patients with moderate to severe depressive symptoms by PHQ-9 (n = 58) were interviewed by a psychiatrist to confirm a clinical diagnosis of depression. Eligible depressed patients were administered escitalopram 10 mg orally once daily for 3 months (n = 12). Thereafter, depressive symptoms and metabolic control measures were reassessed.
   Results The prevalence of moderate to severe depressive symptoms among T2DM patients, according to PHQ-9, was 36.94%, while the prevalence of clinical depression based on interview was 7.64%. Baseline PHQ-9 scores correlated significantly with baseline levels of HbA1c, HDL, cholesterol and triglycerides. Escitalopram treatment intervention resulted in significant improvement of PHQ-9 scores without significantly improving any of the metabolic control measures.
   Conclusion The relationship between depression and T2DM in the context of metabolic syndrome is plausible. However, our results show that escitalopram treatment may not be associated with significant improvement in metabolic control parameters among these patients. Our study has laid the groundwork for future randomised clinical trials with larger sample size and longer follow-up.
C1 [Khassawneh, Adi H.; Abdo, Nour; Al-Mistarehi, Abdel-Hameed; Kheirallah, Khalid A.] Jordan Univ Sci & Technol, Dept Publ Hlth & Family Med, Fac Med, POB 3030, Irbid 22110, Jordan.
   [Alzoubi, Abdallah] Jordan Univ Sci & Technol, Dept Pharmacol, Fac Med, Irbid, Jordan.
   [Alzoubi, Abdallah] Ajman Univ, Coll Med, Ajman, U Arab Emirates.
   [Khasawneh, Aws G.; Albattah, Malak F.] Jordan Univ Sci & Technol, Dept Neurosci, Fac Med, Irbid, Jordan.
   [Abu-Naser, Dania] Al Balqa Appl Univ, Irbid Univ Coll, Dept Appl Sci, Irbid, Jordan.
C3 Jordan University of Science & Technology; Jordan University of Science
   & Technology; Ajman University; Jordan University of Science &
   Technology; Al-Balqa Applied University
RP Khassawneh, AH; Al-Mistarehi, AH (corresponding author), Jordan Univ Sci & Technol, Dept Publ Hlth & Family Med, Fac Med, POB 3030, Irbid 22110, Jordan.
EM ohkhasawneh@just.edu.jo; awalmistarehi18@med.just.edu.jo
RI Kheirallah, Khalid/HJH-7391-2023; Alzoubi, Abdallah/LFU-9102-2024;
   Al-Mistarehi, Abdel-Hameed/ABA-1722-2020; Alrawashdeh, Ahmad/N-3562-2017
OI Khassawneh, Adi/0000-0002-3245-8847; Abu-Naser,
   Dania/0000-0002-8817-4990; Kheirallah, Khalid/0000-0003-4504-4472;
   Al-Mistarehi, Abdel-Hameed/0000-0003-4713-8536; Alrawashdeh,
   Ahmad/0000-0003-2458-8200; Alzoubi, Abdallah/0000-0002-0467-8420
FU Deanship of Research at Jordan University of Science and Technology
   [232/2015]
FX This study was funded by the Deanship of Research at Jordan University
   of Science and Technology (grant #232/2015)
CR Acee Anna M, 2010, Medsurg Nurs, V19, P32
   Al Omari M, 2009, PRIM CARE DIABETES, V3, P173, DOI 10.1016/j.pcd.2009.08.004
   Al Sifri S, 2011, INT J CLIN PRACT, V65, P1132, DOI 10.1111/j.1742-1241.2011.02797.x
   Al-Amer RM, 2011, J DIABETES COMPLICAT, V25, P247, DOI 10.1016/j.jdiacomp.2011.03.001
   Al-Maskari M, 2010, IRAN J IMMUNOL, V7, P124, DOI IJIv7i2A8
   AlHadi AN, 2017, ANN GEN PSYCHIATR, V16, DOI 10.1186/s12991-017-0155-1
   Ali S, 2006, DIABETIC MED, V23, P1165, DOI 10.1111/j.1464-5491.2006.01943.x
   Amer Diabet Assoc, 2008, DIABETES CARE, V31, pS12, DOI 10.2337/dc08-S012
   Amsterdam JD, 2006, NEUROPSYCHOBIOLOGY, V54, P208, DOI 10.1159/000100369
   Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   Andreoulakis E, 2012, HIPPOKRATIA, V16, P205
   [Anonymous], DIABETES FACTS
   Bai XS, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2017-020062
   Banwari G, 2013, REV ARTICLE COMORBID
   Cameron IM, 2011, BRIT J GEN PRACT, V61, DOI 10.3399/bjgp11X583209
   Chen PC, 2013, DIABETES CARE, V36, P376, DOI 10.2337/dc12-0473
   Egede LE, 2002, DIABETES CARE, V25, P464, DOI 10.2337/diacare.25.3.464
   El Mahalli AA, 2015, INT J HEALTH SCI-IJH, V9, P119
   Gagnon J, 2018, FRONT NUTR, V5, DOI 10.3389/fnut.2018.00047
   Gary TL, 2000, DIABETES CARE, V23, P23, DOI 10.2337/diacare.23.1.23
   Gary TL, 2005, INT J PSYCHIAT MED, V35, P377, DOI 10.2190/BQ22-4HU0-P6EK-L7YX
   GAVARD JA, 1993, DIABETES CARE, V16, P1167, DOI 10.2337/diacare.16.8.1167
   Goetzel RZ, 2003, J OCCUP ENVIRON MED, V45, P5, DOI 10.1097/00043764-200301000-00007
   Golden SH, 2008, JAMA-J AM MED ASSOC, V299, P2751, DOI 10.1001/jama.299.23.2751
   Huber CA, 2016, PATIENT PREFER ADHER, V10, P1803, DOI 10.2147/PPA.S115425
   Jammal H, 2013, J DIABETES, V5, P172, DOI 10.1111/1753-0407.12015
   Khamseh ME, 2011, BMC PSYCHIATRY, V11, DOI 10.1186/1471-244X-11-61
   Khassawneh AH, 2020, INT J GEN MED, V13, P803, DOI [10.2147/IJGM.S273900, 10.2147/IJGM.S279300]
   Kirkman MS, 2015, DIABETES CARE, V38, P604, DOI 10.2337/dc14-2098
   Kroenke K, 2010, GEN HOSP PSYCHIAT, V32, P345, DOI 10.1016/j.genhosppsych.2010.03.006
   Levis B, 2020, J CLIN EPIDEMIOL, V122, P115, DOI 10.1016/j.jclinepi.2020.02.002
   Levis B, 2019, BMC MED, V17, DOI 10.1186/s12916-019-1297-6
   Lin EHB, 2010, DIABETES CARE, V33, P264, DOI 10.2337/dc09-1068
   Lin EHB, 2008, J PSYCHOSOM RES, V65, P571, DOI 10.1016/j.jpsychores.2008.06.007
   Lopez-de-Andrés A, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0117346
   Lustman Patrick J, 2007, Curr Diab Rep, V7, P114, DOI 10.1007/s11892-007-0020-8
   Lustman PJ, 2006, ARCH GEN PSYCHIAT, V63, P521, DOI 10.1001/archpsyc.63.5.521
   Malone HE, 2016, NURSE RES, V23, P21, DOI 10.7748/nr.23.5.21.s5
   Manea L, 2015, GEN HOSP PSYCHIAT, V37, P67, DOI 10.1016/j.genhosppsych.2014.09.009
   Mathews J, 2017, INT J BASIC CLIN PHA, V5, P2212
   Mendenhall E, 2014, DIABETES RES CLIN PR, V103, P276, DOI 10.1016/j.diabres.2014.01.001
   Mental Health America, DIAB MENT HLTH
   Osborn CY, 2012, GEN HOSP PSYCHIAT, V34, P249, DOI 10.1016/j.genhosppsych.2012.01.015
   Paile-Hyvarinen Maria, 2003, BMC Fam Pract, V4, P7, DOI 10.1186/1471-2296-4-7
   PALINKAS LA, 1991, DIABETIC MED, V8, P532, DOI 10.1111/j.1464-5491.1991.tb01646.x
   Park M, 2013, GEN HOSP PSYCHIAT, V35, P217, DOI 10.1016/j.genhosppsych.2013.01.006
   Pettersson A, 2015, NORD J PSYCHIAT, V69, P497, DOI 10.3109/08039488.2015.1008568
   Reddy P, 2010, BRIT J GEN PRACT, V60, DOI 10.3399/bjgp10X502128
   Saeed AK, 2003, ANN SAUDI MED, V23, P254, DOI 10.5144/0256-4947.2003.254
   Samrah SM, 2020, PSYCHOL RES BEHAV MA, V13, P823, DOI 10.2147/PRBM.S267459
   Sanchez C, 2014, INT CLIN PSYCHOPHARM, V29, P185, DOI 10.1097/YIC.0000000000000023
   Sevincok L, 2001, EUR PSYCHIAT, V16, P229, DOI 10.1016/S0924-9338(01)00569-7
   Shehatah A, 2010, J AFFECT DISORDERS, V123, P197, DOI 10.1016/j.jad.2009.09.002
   Substance Abuse and Mental Health Services Administration, 2016, DSM 5 CHANG IMPL CHI
   Sweileh WM, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-163
   The World Bank, JORD COUNTR RECL QUE
   Titov Nickolai, 2011, Cognitive Behaviour Therapy, V40, P126, DOI 10.1080/16506073.2010.550059
   Uchendu C, 2017, DIABETIC MED, V34, P328, DOI 10.1111/dme.13195
   van Dooren FEP, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057058
   Vancampfort D, 2015, DEPRESS ANXIETY, V32, P763, DOI 10.1002/da.22387
   Wittkampf KA, 2007, GEN HOSP PSYCHIAT, V29, P388, DOI 10.1016/j.genhosppsych.2007.06.004
   World Health Organization, 2016, DIAB COUNTR PROF
   Wu YY, 2019, CHI 2019: PROCEEDINGS OF THE 2019 CHI CONFERENCE ON HUMAN FACTORS IN COMPUTING SYSTEMS, DOI [10.1145/3290605.3300666, 10.1017/S0033291719001314]
   Yekta Z., 2010, Eastern Mediterranean Health Journal, V16, P286
   Yu M, 2015, CAN J DIABETES, V39, P266, DOI 10.1016/j.jcjd.2014.11.006
   Zhang XP, 2005, AM J EPIDEMIOL, V161, P652, DOI 10.1093/aje/kwi089
   Zhou B, 2016, LANCET, V387, P1513, DOI 10.1016/S0140-6736(16)00618-8
   Zhuang QS, 2017, ONCOTARGET, V8, P23389, DOI 10.18632/oncotarget.15051
NR 68
TC 8
Z9 8
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-5031
EI 1742-1241
J9 INT J CLIN PRACT
JI Int. J. Clin. Pract.
PD APR
PY 2021
VL 75
IS 4
AR e13777
DI 10.1111/ijcp.13777
EA NOV 2020
PG 11
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA RC8GK
UT WOS:000588832300001
PM 33098211
OA gold
DA 2025-06-11
ER

PT J
AU Eggers, AE
AF Eggers, Arnold E.
TI Redrawing Papez' circuit: A theory about how acute stress becomes
   chronic and causes disease
SO MEDICAL HYPOTHESES
LA English
DT Article
ID CORTEX LAYER-II; HIPPOCAMPAL-FORMATION; CUSHINGS-SYNDROME; NEURONS;
   STROKE; IDENTIFICATION; NEUROGENESIS; HYPERTENSION; DEPRESSION; MIGRAINE
AB The diseases of chronic stress include migraine, essential hypertension, depression, and the metabolic syndrome. A theory is presented to explain how acute stress becomes chronic and causes these inter-related conditions. The theory is based on a new "circuit of emotion", which is derived from Papez' famous theory of emotion. The hypothesis is as follows: There is a basic circuit of emotion which runs from the hippocampus (defined as the dentate gyrus plus the CA regions), where emotion arises, to the amygdala and from there to serotonergic pacemaker cells in the dorsal raphe nucleus (DRN). The DRN projects back to the dentate gyrus in two ways: a direct route without a stop and an indirect route via pacemaker cells in the entorhinat cortex. The purpose of the direct route is to promote neurogenesis in the subgranular zone of the dentate; the indirect route has two purposes: to imprint ongoing moments of consciousness onto new dentate cells for retention as memory and to provide a negative feedback loop for regulation of the whole process. The hippocampus, the amygdala, and the DRN all project to the hypothalamus, which are branches off the basic Loop that subserve the autonomic expression of emotion.
   Pathologic overdrive of the DRN causes overdrive of the entorhinal cortex, which leads to excitotoxic cell death of neurons in the hippocampus involved in the negative feedback loop. The disinhibited amygdala and DRN are then free to orchestrate the syndromes of chronic stress. Recovery from chronic stress requires repopulation of the dentate gyrus and restoration of the feedback loop. Excitotoxic cell death in the hippocampus results from either extraordinary acute stress or increased susceptibility to DRN overdrive, as might be caused, for example, by genetic factors, age, high cortisol levels, or incomplete recovery from previous damage.
   Three goals for therapeutic intervention are identified: inhibition of pacemaker cells in the DRN (which can be targeted by ethosuximide and other drugs that block serotonergic pacemaker currents), inhibition of pacemaker cells in the entorhinal cortex (which can be targeted by anti-epileptic drugs that block pacemaker currents in the entorhinat cortex, e.g. phenytoin), and restoration of serotonin levels in the dentate gyrus (which can be accomplished with antidepressants). It is logical to use drugs from all three categories, either atone on in combination, to treat any of the four diseases of chronic stress. This leads to novel therapeutic recommendations, e.g. the use of ethosuximide, mood-stabilizers, and anti-depressants in synergy to treat essential hypertension. (c) 2007 Elsevier Ltd. All rights reserved.
C1 Suny Downstate Med Ctr, Dept Neurol, Brooklyn, NY 11203 USA.
C3 State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University
RP Eggers, AE (corresponding author), Suny Downstate Med Ctr, Dept Neurol, 450 Clarkson Ave,Box 1213, Brooklyn, NY 11203 USA.
EM eggersa@aol.com
CR ALONSO A, 1989, NATURE, V342, P175, DOI 10.1038/342175a0
   BURLHIS TM, 1987, SYNAPSE, V1, P582, DOI 10.1002/syn.890010611
   Dickson CT, 2000, J NEUROPHYSIOL, V83, P2562, DOI 10.1152/jn.2000.83.5.2562
   DORN LD, 1995, CLIN ENDOCRINOL, V43, P433, DOI 10.1111/j.1365-2265.1995.tb02614.x
   Eggers AE, 2005, MED HYPOTHESES, V65, P542, DOI 10.1016/j.mehy.2005.03.020
   Eggers AE, 2003, MED HYPOTHESES, V60, P852, DOI 10.1016/S0306-9877(03)00059-8
   Eggers AE, 2001, MED HYPOTHESES, V56, P360, DOI 10.1054/mehy.2000.1214
   EGGERS AE, 2006, COMMENTARY INT ATHER
   Eggers AE, 2006, MED HYPOTHESES, V67, P1065, DOI 10.1016/j.mehy.2006.04.009
   Eggers AE, 2006, MED HYPOTHESES, V67, P1072, DOI 10.1016/j.mehy.2006.05.023
   Gohil B C, 2001, CNS Spectr, V6, P581
   Kim JJ, 2001, J NEUROSCI, V21, P5222, DOI 10.1523/JNEUROSCI.21-14-05222.2001
   KOHLER C, 1982, NEUROSCIENCE, V7, P951, DOI 10.1016/0306-4522(82)90054-9
   LEIBEL RL, 1984, METABOLISM, V33, P164, DOI 10.1016/0026-0495(84)90130-6
   Malberg JE, 2000, J NEUROSCI, V20, P9104, DOI 10.1523/jneurosci.20-24-09104.2000
   Nelson JC, 1997, AM J PSYCHIAT, V154, P1497, DOI 10.1176/ajp.154.11.1497
   Papez JW, 1937, ARCH NEURO PSYCHIATR, V38, P725, DOI 10.1001/archneurpsyc.1937.02260220069003
   Peeters F, 2004, PSYCHIAT RES, V126, P1, DOI 10.1016/j.psychres.2003.12.010
   RICHARDS JG, 1973, BRAIN RES, V57, P277, DOI 10.1016/0006-8993(73)90136-4
   Sairanen M, 2005, J NEUROSCI, V25, P1089, DOI 10.1523/JNEUROSCI.3741-04.2005
   Santarelli L, 2003, SCIENCE, V301, P805, DOI 10.1126/science.1083328
   SAYAMWONG EH, 2002, J NEUROSCI, V22, P1020
   STARKMAN MN, 1992, BIOL PSYCHIAT, V32, P756, DOI 10.1016/0006-3223(92)90079-F
NR 23
TC 32
Z9 41
U1 0
U2 14
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
J9 MED HYPOTHESES
JI Med. Hypotheses
PY 2007
VL 69
IS 4
BP 852
EP 857
DI 10.1016/j.mehy.2007.01.074
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 210TH
UT WOS:000249478000025
PM 17376605
DA 2025-06-11
ER

PT J
AU Kemp, DE
AF Kemp, David E.
TI Managing the side effects associated with commonly used treatments for
   bipolar depression
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Review
DE Bipolar disorder; Depression; Pharmacotherapy; Side effects
ID OLANZAPINE-FLUOXETINE COMBINATION; CARDIOVASCULAR RISK-FACTORS;
   OPEN-LABEL EXTENSION; DOUBLE-BLIND; METABOLIC SYNDROME; I-DISORDER;
   MAINTENANCE TREATMENT; ATYPICAL ANTIPSYCHOTICS; MOOD STABILIZER;
   WEIGHT-GAIN
AB Background: The most commonly used pharmacologic therapies for bipolar depression are mood stabilizers, atypical antipsychotics, and antidepressants. This paper reviews common side effects associated with these medications and provides recommendations for managing adverse medication effects in clinical practice.
   Methods: Narrative review based on literature searches of Medline and evidence-based treatment guidelines for agents that have been approved by the US Food and Drug Administration and/or are commonly used to treat bipolar depression.
   Results: Side effects of bipolar depression pharmacotherapies are common and vary by medication, with weight gain, metabolic dysregulation, sedation/somnolence, and akathisia among those observed most frequently. These adverse events (weight gain and sedation/somnolence, in particular) negatively affect treatment adherence in patients with bipolar disorder. Furthermore, endocrine and metabolic comorbidities, weight gain, and obesity may reduce the likelihood of positive clinical responses to pharmacologic therapies. Clinicians may consider switching patients to bipolar depression medication(s) with a lower propensity for sedation or adverse metabolic effects. Lifestyle modification (e.g., dietary changes, exercise) is an important component in the treatment of weight gain/obesity, dyslipidemia, hypertension, and hyperglycemia; in addition, a wide range of medications are available as therapeutic options for patients in whom non-pharmacologic management strategies are insufficient. The use of adjunctive medication may also reduce treatment-related sedation and somnolence.
   Limitations: The selection of relevant studies from the literature search relied primarily on the author's expertise in the area of bipolar depression and knowledge of the issues addressed.
   Conclusions: Successful treatment of bipolar depression extends beyond managing mood symptoms to also monitoring adverse medication events and managing associated medical disorders. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Kemp, David E.] Case Western Reserve Univ, Univ Hosp Case Med Ctr, Dept Psychiat, Cleveland, OH 44106 USA.
C3 University System of Ohio; Case Western Reserve University; Case Western
   Reserve University Hospital
RP Kemp, DE (corresponding author), Case Western Reserve Univ, 10524 Euclid Ave,12th Floor, Cleveland, OH 44106 USA.
EM kemp.david@gmail.com
FU Teva Pharmaceuticals, North Wales, PA; Sunovion Pharmaceuticals,
   Marlborough, MA
FX Funding for technical editorial and medical writing support was provided
   by Teva Pharmaceuticals, North Wales, PA. Publication of the manuscript
   was supported by an independent medical education grant from Sunovion
   Pharmaceuticals, Marlborough, MA.
CR American Diabetes Association, 2004, DIABETES CARE S1, V36, pS67
   [Anonymous], 2004, J CLIN PSYCHIAT, V65, P267
   [Anonymous], 2012, DIABETES CARE, V35, pS11, DOI [10.2337/dc35-S011, 10.2337/dc12-s004]
   [Anonymous], VA DOD CLIN PRACT GU
   [Anonymous], 2012, SYMB OL FLUOX HYDR C
   [Anonymous], 2013, SER QUET FUM TABL
   [Anonymous], 2012, XEN ORL CAPS OR US
   [Anonymous], 2011, LAM LAM TABL
   [Anonymous], 2013, QSYM PHENT TOP EXT R
   [Anonymous], 2012, AB AR TABL
   [Anonymous], 2013, NUV ARM TABL C 4
   [Anonymous], 2012, GEOD ZIPR HCI CAPS
   [Anonymous], 2010, PROV MOD TABL C 4
   Apovian CM, 2013, OBESITY, V21, P935, DOI 10.1002/oby.20309
   Appel LJ, 2009, J CLIN HYPERTENS, V11, P358, DOI 10.1111/j.1751-7176.2009.00136.x
   Bet PM, 2013, EUR NEUROPSYCHOPHARM, V23, P1443, DOI 10.1016/j.euroneuro.2013.05.001
   Bielski RJ, 2004, J CLIN PSYCHIAT, V65, P1190, DOI 10.4088/JCP.v65n0906
   Birkenaes AB, 2006, J CLIN PSYCHIAT, V67, P425, DOI 10.4088/JCP.v67n0314
   Birkenaes AB, 2007, J CLIN PSYCHIAT, V68, P917, DOI 10.4088/JCP.v68n0614
   Bowden CL, 2006, AM J PSYCHIAT, V163, P1199, DOI 10.1176/appi.ajp.163.7.1199
   Bowden CL, 2000, ARCH GEN PSYCHIAT, V57, P481, DOI 10.1001/archpsyc.57.5.481
   Brietzke E, 2011, EXPERT REV NEUROTHER, V11, P1017, DOI [10.1586/ERN.10.185, 10.1586/ern.10.185]
   Brown E, 2009, INT J NEUROPSYCHOPH, V12, P773, DOI 10.1017/S1461145708009735
   Brown EB, 2006, J CLIN PSYCHIAT, V67, P1025, DOI 10.4088/JCP.v67n0703
   Calabrese J R, 1995, Ann Clin Psychiatry, V7, P103, DOI 10.3109/10401239509149036
   Calabrese JR, 2010, J CLIN PSYCHIAT, V71, P1363, DOI 10.4088/JCP.09m05900gry
   Calabrese JR, 2003, J CLIN PSYCHIAT, V64, P1013, DOI 10.4088/JCP.v64n0906
   Calabrese JR, 1999, J CLIN PSYCHIAT, V60, P79, DOI 10.4088/JCP.v60n0203
   Calabrese JR, 2002, J CLIN PSYCHIAT, V63, P1012, DOI 10.4088/JCP.v63n1110
   Calabrese JR, 2005, AM J PSYCHIAT, V162, P1351, DOI 10.1176/appi.ajp.162.7.1351
   Calkin CV, 2013, ANN MED, V45, P171, DOI 10.3109/07853890.2012.687835
   Carlson PJ, 2004, BIPOLAR DISORD, V6, P416, DOI 10.1111/j.1399-5618.2004.00132.x
   Chengappa KNR, 2006, J CLIN PSYCHIAT, V67, P1698, DOI 10.4088/JCP.v67n1105
   COHEN LS, 1994, JAMA-J AM MED ASSOC, V271, P146, DOI 10.1001/jama.271.2.146
   Correll Christoph U, 2010, Psychiatr Serv, V61, P892, DOI 10.1176/ps.2010.61.9.892
   Corya SA, 2006, J CLIN PSYCHIAT, V67, P798, DOI 10.4088/JCP.v67n0514
   Daumit GL, 2013, NEW ENGL J MED, V368, P1594, DOI 10.1056/NEJMoa1214530
   de Oliveira JL, 2010, REV ASSOC MED BRAS, V56, P600, DOI 10.1590/S0104-42302010000500025
   Dell'Osso B, 2013, INT J NEUROPSYCHOPH, V16, P55, DOI 10.1017/S1461145712000326
   Ehret M, 2010, J CLIN PSYCHIAT, V71, P1286, DOI 10.4088/JCP.09m05274yel
   Fagiolini Andrea, 2007, Curr Psychiatry Rep, V9, P521, DOI 10.1007/s11920-007-0071-1
   Fava Maurizio, 2005, Prim Care Companion J Clin Psychiatry, V7, P106
   Ferdinand KC, 2011, J CLIN HYPERTENS, V13, P636, DOI 10.1111/j.1751-7176.2011.00506.x
   Fidler MC, 2011, J CLIN ENDOCR METAB, V96, P3067, DOI 10.1210/jc.2011-1256
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Fountoulakis KN, 2012, J PSYCHOPHARMACOL, V26, P1401, DOI 10.1177/0269881112440514
   Frye MA, 2007, AM J PSYCHIAT, V164, P1242, DOI 10.1176/appi.ajp.2007.06060981
   Frye MA, 2011, NEW ENGL J MED, V364, P51, DOI 10.1056/NEJMcp1000402
   Gao KM, 2008, J CLIN PSYCHOPHARM, V28, P203, DOI 10.1097/JCP.0b013e318166c4d5
   Ghaemi SN, 2007, J CLIN PSYCHIAT, V68, P1840, DOI 10.4088/JCP.v68n1203
   Goldberg JF, 2009, BIPOLAR DISORD, V11, P123, DOI 10.1111/j.1399-5618.2009.00716.x
   Goldenberg Marvin M, 2012, P T, V37, P499
   Goldstein DJ, 2002, J CLIN PSYCHIAT, V63, P225, DOI 10.4088/JCP.v63n0309
   Goodwin GM, 2009, J PSYCHOPHARMACOL, V23, P346, DOI 10.1177/0269881109102919
   Gradman AH, 2011, J CLIN HYPERTENS, V13, P146, DOI 10.1111/j.1751-7176.2010.00397.x
   Greenway FL, 2010, LANCET, V376, P595, DOI 10.1016/S0140-6736(10)60888-4
   Greenway FL, 2009, J CLIN ENDOCR METAB, V94, P4898, DOI 10.1210/jc.2009-1350
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Haddad PM, 2009, EXPERT OPIN DRUG MET, V5, P539, DOI [10.1517/17425250902911455 , 10.1517/17425250902911455]
   Hasnain M, 2012, POSTGRAD MED, V124, P154, DOI 10.3810/pgm.2012.07.2577
   Henderson DC, 2007, J CLIN PSYCHIAT, V68, P18
   Henderson DC, 2006, J CLIN PSYCHIAT, V67, P789, DOI 10.4088/JCP.v67n0513
   Holmes LB, 2008, NEUROLOGY, V70, P2152, DOI 10.1212/01.wnl.0000304343.45104.d6
   Jancin B, 2013, CLIN PSYCHIAT NEWS
   Janssen R&D, 2021, ULTRAM TRAM HYDR TAB
   Joffe H, 2006, BIOL PSYCHIAT, V59, P1078, DOI 10.1016/j.biopsych.2005.10.017
   Joffe H, 2006, BIOL PSYCHIAT, V60, P1378, DOI 10.1016/j.biopsych.2006.05.027
   Kane JM, 2008, J CLIN PSYCHIAT, V69, P18
   Kane JM, 2009, J CLIN PSYCHIAT, V70, P627, DOI 10.4088/JCP.08r04210
   Keck PE, 2007, J CLIN PSYCHIAT, V68, P1480, DOI 10.4088/JCP.v68n1003
   Keck PE, 2006, J CLIN PSYCHIAT, V67, P626, DOI 10.4088/JCP.v67n0414
   Kemp DE, 2014, ACTA PSYCHIAT SCAND, V129, P24, DOI 10.1111/acps.12101
   Kemp DE, 2014, CNS DRUGS, V28, P571, DOI 10.1007/s40263-014-0158-2
   Kemp DE, 2012, PSYCHIAT ANN, V42, P179, DOI 10.3928/00485713-20120507-05
   Kemp DE, 2012, J AFFECT DISORDERS, V136, P1164, DOI 10.1016/j.jad.2011.06.033
   Kemp DE, 2012, EUR NEUROPSYCHOPHARM, V22, P123, DOI 10.1016/j.euroneuro.2011.06.005
   Kemp DE, 2010, J CLIN PSYCHIAT, V71, P1138, DOI 10.4088/JCP.09m05159gre
   Ketter Terence A, 2003, Ann Clin Psychiatry, V15, P95, DOI 10.3109/10401230309085675
   Kupka RW, 2007, BIPOLAR DISORD, V9, P531, DOI 10.1111/j.1399-5618.2007.00467.x
   Loebel A, 2014, AM J PSYCHIAT, V171, P160, DOI 10.1176/appi.ajp.2013.13070984
   Loebel A, 2014, AM J PSYCHIAT, V171, P169, DOI 10.1176/appi.ajp.2013.13070985
   Lombardo I, 2012, J CLIN PSYCHOPHARM, V32, P470, DOI 10.1097/JCP.0b013e31825ccde5
   Lorberg B, 2009, INT J NEUROPSYCHOPH, V12, P257, DOI 10.1017/S1461145708009504
   Malhi GS, 2012, BIPOLAR DISORD, V14, P1, DOI 10.1111/j.1399-5618.2012.00989.x
   McElroy SL, 2012, CURR PSYCHIAT REP, V14, P650, DOI 10.1007/s11920-012-0313-8
   McElroy SL, 2010, J CLIN PSYCHIAT, V71, P163, DOI 10.4088/JCP.08m04942gre
   McIntyre R.S., 2011, PRIM CARE COMPANION, V13, pe1
   McIntyre RS, 2012, ANN CLIN PSYCHIATRY, V24, P69
   McIntyre RS, 2002, BIPOLAR DISORD, V4, P207, DOI 10.1034/j.1399-5618.2002.01189.x
   McIntyre RS, 2005, J CLIN PSYCHIAT, V66, P28
   McKnight RF, 2012, LANCET, V379, P721, DOI 10.1016/S0140-6736(11)61516-X
   Miller Del D, 2004, Prim Care Companion J Clin Psychiatry, V6, P3
   Muench J, 2010, AM FAM PHYSICIAN, V81, P617
   Narula PK, 2010, SCHIZOPHR RES, V118, P218, DOI 10.1016/j.schres.2010.02.001
   Newcomer JW, 2007, J CLIN PSYCHIAT, V68, P8
   Ng F, 2009, BIPOLAR DISORD, V11, P559, DOI 10.1111/j.1399-5618.2009.00737.x
   NICE, 2006, Surveillance of ObsessiveCompulsive Disorder and Body Dysmorphic Disorder: Treatment
   Ornoy A, 2009, REPROD TOXICOL, V28, P1, DOI 10.1016/j.reprotox.2009.02.014
   Pacchiarotti I, 2013, AM J PSYCHIAT, V170, P1249, DOI 10.1176/appi.ajp.2013.13020185
   Papakostas GI, 2008, J CLIN PSYCHIAT, V69, P1287, DOI 10.4088/JCP.v69n0812
   Sachs G, 2006, BIPOLAR DISORD, V8, P175, DOI 10.1111/j.1399-5618.2006.00308.x
   Sachs GS, 2011, J CLIN PSYCHIAT, V72, P1413, DOI 10.4088/JCP.09m05934
   Salvi V, 2008, GEN HOSP PSYCHIAT, V30, P318, DOI 10.1016/j.genhosppsych.2008.04.009
   Sanchez-Moreno J, 2009, PSYCHOTHER PSYCHOSOM, V78, P285, DOI 10.1159/000228249
   Serretti A, 2010, J CLIN PSYCHIAT, V71, P1259, DOI 10.4088/JCP.09r05346blu
   Serretti A, 2009, J CLIN PSYCHOPHARM, V29, P259, DOI 10.1097/JCP.0b013e3181a5233f
   Severus WE, 2008, BIPOLAR DISORD, V10, P231, DOI 10.1111/j.1399-5618.2007.00475.x
   Sicras A, 2008, BIPOLAR DISORD, V10, P607, DOI 10.1111/j.1399-5618.2008.00599.x
   Simms KM, 2012, NEUROLOGY, V78, P921, DOI 10.1212/WNL.0b013e31824c4634
   Sir A, 2005, J CLIN PSYCHIAT, V66, P1312, DOI 10.4088/JCP.v66n1015
   Suppes T, 2010, J AFFECT DISORDERS, V121, P106, DOI 10.1016/j.jad.2009.10.007
   Suppes T, 2008, J AFFECT DISORDERS, V111, P334, DOI 10.1016/j.jad.2008.02.004
   Svetkey LP, 1999, ARCH INTERN MED, V159, P285, DOI 10.1001/archinte.159.3.285
   Tchoukhine E, 2011, J CLIN PSYCHIAT, V72, P326, DOI 10.4088/JCP.09m05283yel
   Thase ME, 2005, J CLIN PSYCHIAT, V66, P974, DOI 10.4088/JCP.v66n0803
   Thase ME, 2008, J CLIN PSYCHOPHARM, V28, P13, DOI 10.1097/jcp.0b013e3181618eb4
   Thase ME, 2006, J CLIN PSYCHOPHARM, V26, P600, DOI 10.1097/01.jcp.0000248603.76231.b7
   Tohen M, 2003, ARCH GEN PSYCHIAT, V60, P1079, DOI 10.1001/archpsyc.60.11.1079
   Tohen M, 2003, AM J PSYCHIAT, V160, P1263, DOI 10.1176/appi.ajp.160.7.1263
   Tsigos C, 2008, OBESITY FACTS, V1, P106, DOI 10.1159/000126822
   Vancampfort D, 2013, AM J PSYCHIAT, V170, P265, DOI 10.1176/appi.ajp.2012.12050620
   Vuksan-Cusa B, 2010, PSYCHIAT DANUB, V22, P275
   Watanabe N, 2010, CNS DRUGS, V24, P35, DOI 10.2165/11319480-000000000-00000
   Yatham LN, 2013, BIPOLAR DISORD, V15, P1, DOI 10.1111/bdi.12025
   Yatham LN, 2005, BIPOLAR DISORD, V7, P5, DOI 10.1111/j.1399-5618.2005.00219.x
   Young AH, 2014, WORLD J BIOL PSYCHIA, V15, P96, DOI 10.3109/15622975.2012.665177
   Young AH, 2010, J CLIN PSYCHIAT, V71, P150, DOI 10.4088/JCP.08m04995gre
NR 127
TC 50
Z9 53
U1 0
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD DEC
PY 2014
VL 169
SU 1
BP S34
EP S44
DI 10.1016/S0165-0327(14)70007-2
PG 11
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA CP6OT
UT WOS:000360007700006
PM 25533913
OA hybrid
DA 2025-06-11
ER

PT J
AU Valentine, RJ
   McAuley, E
   Vieira, VJ
   Baynard, T
   Hu, L
   Evans, EM
   Woods, JA
AF Valentine, Rudy J.
   McAuley, Edward
   Vieira, Victoria J.
   Baynard, Tracy
   Hu, Liang
   Evans, Ellen M.
   Woods, Jeffrey A.
TI Sex differences in the relationship between obesity, C-reactive protein,
   physical activity, depression, sleep quality and fatigue in older adults
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Fatigue; Adiposity; Inflammation; Sex differences; Depression; Fitness;
   Physical activity
ID EXCESSIVE DAYTIME SLEEPINESS; BODY-MASS INDEX; REPORTED FUNCTIONAL
   LIMITATION; SELF-PERCEIVED FATIGUE; INSULIN-RESISTANCE; FAT MASS;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; ADIPOSE-TISSUE;
   UNITED-STATES
AB Fatigue is a serious health concern in the elderly. Sex differences exist in adiposity, systemic inflammation, physical activity/fitness and fatigue; however, the relations among these variables remain inadequately characterized impeding the development of fatigue prevention strategies. Measures of adiposity, C-reactive protein, physical activity, aerobic fitness, fatigue, sleep quality and depression were obtained from 127 community-dwelling older adults. Although similar in age (70 y) and BMI (28.0 kg/m(2)) women (n = 80) reported 63% greater fatigue than men (p = 0.04). Adiposity (r = 0.44), CRP (r = 0.29), physical activity (r = -0.26) and fitness (r = -0.41) were related to fatigue in women (all p < 0.05), but not in men. Depression was also related to fatigue in women (r = 0.37), and was the only variable related to fatigue in men (r = 0.42). In women, fatigue was independently explained (all p < 0.05) by CRP (6.6%), depression (6.3%), physical activity (5.8%), and adiposity (3.9%); however, in men, only depression explained variance in fatigue (12.0%). CRP was 40% higher and adiposity 12% higher in women reporting fatigue compared to those with no fatigue; no such differences existed in men. Obese women perceived a greater degree of fatigue than non-obese women, but this was not the case in men. Women report more fatigue than men which was independently associated with inflammation, depression, physical activity and adiposity, whereas in men the only independent predictor was depression. Strategies to prevent fatigue may differ in older women and men, especially with regard to inflammation, physical activity and adiposity. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Valentine, Rudy J.; McAuley, Edward; Baynard, Tracy; Evans, Ellen M.; Woods, Jeffrey A.] Univ Illinois, Dept Kinesiol & Community Hlth, Urbana, IL 61801 USA.
   [Vieira, Victoria J.; Evans, Ellen M.; Woods, Jeffrey A.] Univ Illinois, Div Nutr Sci, Urbana, IL 61801 USA.
   [Vieira, Victoria J.; Woods, Jeffrey A.] Univ Illinois, Integrat Immunol & Behav Program, Urbana, IL 61801 USA.
   [Hu, Liang] Tianjin Univ Sport, Tianjin, Peoples R China.
C3 University of Illinois System; University of Illinois Urbana-Champaign;
   University of Illinois System; University of Illinois Urbana-Champaign;
   University of Illinois System; University of Illinois Urbana-Champaign;
   Tianjin University of Sport
RP Woods, JA (corresponding author), Univ Illinois, Dept Kinesiol & Community Hlth, 906 S Goodwin Ave, Urbana, IL 61801 USA.
EM woods1@illinois.edu
RI Baynard, Tracy/AAN-8711-2021; McAuley, Edward/A-9508-2008
OI Baynard, Tracy/0000-0002-5150-4095; Vieira-Potter,
   Victoria/0000-0001-7563-0806
FU NIA NIH HHS [R01 AG-18861] Funding Source: Medline
CR Arena Ross, 2006, J Cardiopulm Rehabil, V26, P323, DOI 10.1097/00008483-200609000-00009
   Barzilay JI, 2007, ARCH INTERN MED, V167, P635, DOI 10.1001/archinte.167.7.635
   Basta M, 2008, J CLIN SLEEP MED, V4, P19
   Bixler EO, 2005, J CLIN ENDOCR METAB, V90, P4510, DOI 10.1210/jc.2005-0035
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1016/0165-1781(89)90047-4
   Cappuccio FP, 2007, HYPERTENSION, V50, P693, DOI 10.1161/HYPERTENSIONAHA.107.095471
   Chen HL, 2008, J AM GERIATR SOC, V56, P689, DOI 10.1111/j.1532-5415.2007.01624.x
   CHEN MK, 1986, PREV MED, V15, P74, DOI 10.1016/0091-7435(86)90037-X
   Cheng MH, 2008, MENOPAUSE, V15, P958, DOI 10.1097/gme.0b013e318160dafa
   COHEN S, 1983, J APPL SOC PSYCHOL, V13, P99, DOI 10.1111/j.1559-1816.1983.tb02325.x
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   Davis JW, 1998, J AM GERIATR SOC, V46, P274, DOI 10.1111/j.1532-5415.1998.tb01037.x
   Davison KK, 2002, J AM GERIATR SOC, V50, P1802, DOI 10.1046/j.1532-5415.2002.50508.x
   Evans EM, 2001, J APPL PHYSIOL, V90, P2033, DOI 10.1152/jappl.2001.90.6.2033
   Florez H, 2008, J AM GERIATR SOC, V56, P558, DOI 10.1111/j.1532-5415.2007.01584.x
   Friedmann JM, 2001, J AM GERIATR SOC, V49, P398, DOI 10.1046/j.1532-5415.2001.49082.x
   HEYWARD VH, 1996, APPL BODY COMPOSITIO, P135
   HUBERT HB, 1993, J RHEUMATOL, V20, P480
   Hwang SS, 2003, CANCER INVEST, V21, P363, DOI 10.1081/CNV-120018227
   HYYPPA MT, 1993, J PSYCHOSOM RES, V37, P589, DOI 10.1016/0022-3999(93)90053-I
   Jean-Pierre P, 2007, ONCOLOGIST, V12, P11, DOI 10.1634/theoncologist.12-S1-11
   Joseph Cherian, 2005, Molecular Aspects of Medicine, V26, P181, DOI 10.1016/j.mam.2005.01.004
   KRAHNSTOEVER K, 2002, J AM GERIATR SOC, V50, P1802
   Kyle UG, 2001, EUR J CLIN NUTR, V55, P663, DOI 10.1038/sj.ejcn.1601198
   Lebrun CEI, 2006, MENOPAUSE, V13, P474, DOI 10.1097/01.gme.0000222331.23478.ec
   Leng SX, 2007, J AM GERIATR SOC, V55, P864, DOI 10.1111/j.1532-5415.2007.01186.x
   Liao S, 2000, J AM GERIATR SOC, V48, P426, DOI 10.1111/j.1532-5415.2000.tb04702.x
   Lim W, 2008, PSYCHOSOMATICS, V49, P23, DOI 10.1176/appi.psy.49.1.23
   Lim WJ, 2005, ARCH INTERN MED, V165, P910, DOI 10.1001/archinte.165.8.910
   Lobo RA, 2008, MATURITAS, V60, P10, DOI 10.1016/j.maturitas.2008.02.008
   Luctkar-Flude Marian Florence, 2007, Cancer Nurs, V30, pE35
   Newman AB, 2000, J AM GERIATR SOC, V48, P115, DOI 10.1111/j.1532-5415.2000.tb03901.x
   Nicklas BJ, 2004, AM J EPIDEMIOL, V160, P741, DOI 10.1093/aje/kwh281
   Ogden CL, 2006, JAMA-J AM MED ASSOC, V295, P1549, DOI 10.1001/jama.295.13.1549
   Pearson TA, 2003, CIRCULATION, V107, P499, DOI 10.1161/01.CIR.0000052939.59093.45
   Pedersen M, 2003, MECH AGEING DEV, V124, P495, DOI 10.1016/S0047-6374(03)00027-7
   Poluri Ashok, 2005, Phys Med Rehabil Clin N Am, V16, P91, DOI 10.1016/j.pmr.2004.06.006
   Puetz TW, 2008, PSYCHOTHER PSYCHOSOM, V77, P167, DOI 10.1159/000116610
   Resnick HE, 2006, J CLIN SLEEP MED, V2, P163
   Resta O, 2003, J INTERN MED, V253, P536, DOI 10.1046/j.1365-2796.2003.01133.x
   Resta O, 2001, INT J OBESITY, V25, P669, DOI 10.1038/sj.ijo.0801603
   Ridker PM, 2003, AM J CARDIOL, V92, p17K, DOI 10.1016/S0002-9149(03)00774-4
   Rockwood K, 2001, J AM GERIATR SOC, V49, P639, DOI 10.1046/j.1532-5415.2001.49125.x
   Saltevo J, 2008, DIABETIC MED, V25, P747, DOI 10.1111/j.1464-5491.2008.02440.x
   Schwartz AL, 2002, J CLIN EPIDEMIOL, V55, P239, DOI 10.1016/S0895-4356(01)00469-3
   Sternfeld B, 2002, AM J EPIDEMIOL, V156, P110, DOI 10.1093/aje/kwf023
   Suarez EC, 2008, BRAIN BEHAV IMMUN, V22, P960, DOI 10.1016/j.bbi.2008.01.011
   Tankó LB, 2006, CLIMACTERIC, V9, P169, DOI 10.1080/13697130600738765
   Thorand B, 2006, ATHEROSCLEROSIS, V184, P216, DOI 10.1016/j.atherosclerosis.2005.04.011
   Thorand B, 2007, DIABETES CARE, V30, P854, DOI 10.2337/dc06-1693
   Tonstad S, 2007, METABOLISM, V56, P260, DOI 10.1016/j.metabol.2006.10.006
   Turvey CL, 2002, J AM GERIATR SOC, V50, P2003, DOI 10.1046/j.1532-5415.2002.50612.x
   VALENTINE RJ, 2008, MENOPAUSE IN PRESS
   Van Hooff MLM, 2007, J OCCUP HEALTH, V49, P224, DOI 10.1539/joh.49.224
   van Mens-Verhulst J, 1997, WOMEN HEALTH, V26, P51
   Vgontzas AN, 2006, ANN NY ACAD SCI, V1083, P329, DOI 10.1196/annals.1367.023
   Vgontzas AN, 1997, J CLIN ENDOCR METAB, V82, P1313, DOI 10.1210/jc.82.5.1313
   VOGEL JA, 1986, J APPL PHYSIOL, V60, P494, DOI 10.1152/jappl.1986.60.2.494
   Washburn RA, 1999, J CLIN EPIDEMIOL, V52, P643, DOI 10.1016/S0895-4356(99)00049-9
   Whitney CW, 1998, SLEEP, V21, P27, DOI 10.1093/sleep/21.1.27
   Wick Jeannette Y, 2007, Consult Pharm, V22, P566, DOI 10.4140/TCP.n.2007.566
   WINGARD DL, 1983, SLEEP, V6, P102, DOI 10.1093/sleep/6.2.102
   YESAVAGE JA, 1983, J PSYCHIATR RES, V17, P37, DOI 10.1016/0022-3956(82)90033-4
   Zakai NA, 2007, J THROMB HAEMOST, V5, P1128, DOI 10.1111/j.1538-7836.2007.02528.x
   Zamboni M, 1999, J AM GERIATR SOC, V47, P1403, DOI 10.1111/j.1532-5415.1999.tb01557.x
   Zoico E, 2004, INT J OBESITY, V28, P234, DOI 10.1038/sj.ijo.0802552
NR 66
TC 62
Z9 78
U1 0
U2 30
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD JUL
PY 2009
VL 23
IS 5
SI SI
BP 643
EP 648
DI 10.1016/j.bbi.2008.12.003
PG 6
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA 461NL
UT WOS:000267274000011
PM 19133324
DA 2025-06-11
ER

PT J
AU Fond, GB
   Lagier, JC
   Honore, S
   Lancon, C
   Korchia, T
   De Verville, PLS
   Llorca, PM
   Auquier, P
   Guedj, E
   Boyer, L
AF Fond, Guillaume B.
   Lagier, Jean-Christophe
   Honore, Stephane
   Lancon, Christophe
   Korchia, Theo
   De Verville, Pierre-Louis Sunhary
   Llorca, Pierre-Michel
   Auquier, Pascal
   Guedj, Eric
   Boyer, Laurent
TI Microbiota-Orientated Treatments for Major Depression and Schizophrenia
SO NUTRIENTS
LA English
DT Review
DE psychiatry; schizophrenia; depression; microbiota; transplantation
ID CLOSTRIDIUM-DIFFICILE INFECTION; IRRITABLE-BOWEL-SYNDROME; C-REACTIVE
   PROTEIN; QUALITY-OF-LIFE; FECAL MICROBIOTA; GUT MICROBIOTA;
   ULCERATIVE-COLITIS; METABOLIC SYNDROME; TRANSPLANTATION; SYMPTOMS
AB Background and significance. There is a need to develop new hypothesis-driven treatment for both both major depression (MD) and schizophrenia in which the risk of depression is 5 times higher than the general population. Major depression has been also associated with poor illness outcomes including pain, metabolic disturbances, and less adherence. Conventional antidepressants are partly effective, and 44% of the subjects remain unremitted under treatment. Improving MD treatment efficacy is thus needed to improve the SZ prognosis. Microbiota-orientated treatments are currently one of the most promising tracks. Method. This work is a systematic review synthetizing data of arguments to develop microbiota-orientated treatments (including fecal microbiota transplantation (FMT)) in major depression and schizophrenia. Results. The effectiveness of probiotic administration in MD constitutes a strong evidence for developing microbiota-orientated treatments. Probiotics have yielded medium-to-large significant effects on depressive symptoms, but it is still unclear if the effect is maintained following probiotic discontinuation. Several factors may limit MD improvement when using probiotics, including the small number of bacterial strains administered in probiotic complementary agents, as well as the presence of a disturbed gut microbiota that probably limits the probiotics' impact. FMT is a safe technique enabling to improve microbiota in several gut disorders. The benefit/risk ratio of FMT has been discussed and has been recently improved by capsule administration. Conclusion. Cleaning up the gut microbiota by transplanting a totally new human gut microbiota in one shot, which is referred to as FMT, is likely to strongly improve the efficacy of microbiota-orientated treatments in MD and schizophrenia and maintain the effect over time. This hypothesis should be tested in future clinical trials.
C1 [Fond, Guillaume B.; Honore, Stephane; Lancon, Christophe; Korchia, Theo; De Verville, Pierre-Louis Sunhary; Auquier, Pascal; Boyer, Laurent] Aix Marseille Univ, Hop Univ Marseille, CEReSS Hlth Serv Res & Qual Life Ctr, Dept Psychiatrie Univ,EA 3279, 27 Blvd Jean Moulin, F-13005 Marseille, France.
   [Lagier, Jean-Christophe] Aix Marseille Univ, Inst Hosp Univ Mediterranee Infect, AP HP, Inst Rech Dev Microbes Evolut Phylogeny & Infect, F-13005 Marseille, France.
   [Llorca, Pierre-Michel] CHU Clermont Ferrand, F-63000 Cllermont Ferrand, France.
   [Guedj, Eric] Aix Marseille Univ, Ecole Cent Marseille, Inst Fresnel, Dept Med Nucl,CERIMED,CNRS,UMR 7249, F-13005 Marseille, France.
C3 Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille;
   Assistance Publique Hopitaux Paris (APHP); Aix-Marseille Universite;
   Universite Clermont Auvergne (UCA); CHU Clermont Ferrand; Centre
   National de la Recherche Scientifique (CNRS); CNRS - Institute for
   Engineering & Systems Sciences (INSIS); Aix-Marseille Universite
RP Fond, GB (corresponding author), Aix Marseille Univ, Hop Univ Marseille, CEReSS Hlth Serv Res & Qual Life Ctr, Dept Psychiatrie Univ,EA 3279, 27 Blvd Jean Moulin, F-13005 Marseille, France.
EM guillaume.fond@gmail.com; JeanChristophe.LAGIER@ap-hm.fr;
   stephane.honore@ap-hm.fr; christophe.lancon@ap-hm.fr;
   theo.korchia@ap-hm.fr; deverville.pierrelouis@gmail.com;
   pmllorca@chu-clermontferrand.fr; pascal.auquier@univ-amu.fr;
   eric.guedj@ap-hm.fr; laurent.boyer@ap-hm.fr
RI Fond, Guillaume/D-7646-2011; Guedj, Eric/AAK-1589-2020; Boyer,
   Laurent/E-5728-2016; Lagier, Jean-Christophe/AAY-3837-2021
OI Boyer, Laurent/0000-0003-1229-6622; Lagier,
   Jean-Christophe/0000-0003-0771-8245; Korchia, Theo/0000-0002-6392-9322;
   Llorca, Pierre michel/0000-0001-7438-8990
FU Hopitaux Universitaires de Marseille (HUM) [AORC-2018]
FX This work was funded by Hopitaux Universitaires de Marseille (HUM),
   grant number AORC-2018.
CR Alessandrini M, 2016, SCHIZOPHR RES, V171, P27, DOI 10.1016/j.schres.2016.01.012
   Andrianarisoa M, 2017, SCHIZOPHR RES, V185, P173, DOI 10.1016/j.schres.2016.12.021
   Austin M, 2014, AM J MED, V127, P479, DOI 10.1016/j.amjmed.2014.02.017
   Cammarota G, 2015, ALIMENT PHARM THER, V41, P835, DOI 10.1111/apt.13144
   Campos AC, 2016, BEHAV BRAIN RES, V312, P186, DOI 10.1016/j.bbr.2016.06.027
   Chen JJ, 2018, NEUROPSYCH DIS TREAT, V14, P647, DOI 10.2147/NDT.S159322
   Chen Z, 2018, NEUROREPORT, V29, P417, DOI 10.1097/WNR.0000000000000985
   Cipriani A, 2018, LANCET, V391, P1357, DOI 10.1016/S0140-6736(17)32802-7
   Costello SP, 2019, JAMA-J AM MED ASSOC, V321, P156, DOI 10.1001/jama.2018.20046
   Cui BT, 2015, J GASTROEN HEPATOL, V30, P51, DOI 10.1111/jgh.12727
   Faugere M, 2018, J AFFECT DISORDERS, V225, P671, DOI 10.1016/j.jad.2017.09.004
   Flint HJ, 2011, J CLIN GASTROENTEROL, V45, pS128, DOI 10.1097/MCG.0b013e31821f44c4
   Fond G, 2019, ENCEPHALE, V45, P457, DOI 10.1016/j.encep.2019.11.001
   Fond G, 2019, PROG NEURO-PSYCHOPH, V94, DOI 10.1016/j.pnpbp.2019.109654
   Fond G, 2019, ENCEPHALE, V45, P99, DOI 10.1016/j.encep.2019.01.002
   Fond G, 2018, EUR ARCH PSY CLIN N, V268, P541, DOI 10.1007/s00406-017-0847-1
   Fond G, 2019, EUR ARCH PSY CLIN N, V269, P985, DOI 10.1007/s00406-018-0908-0
   Fond G, 2017, EUR ARCH PSY CLIN N, V267, P465, DOI 10.1007/s00406-017-0771-4
   Fond G, 2016, J AFFECT DISORDERS, V191, P209, DOI 10.1016/j.jad.2015.11.017
   Fond G, 2019, PRESSE MED, V48, P365, DOI 10.1016/j.lpm.2018.12.004
   Fond G, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00392
   Fond G, 2018, BRIT J PSYCHIAT, V213, P464, DOI 10.1192/bjp.2018.87
   Fond G, 2018, PROG NEURO-PSYCHOPH, V85, P62, DOI 10.1016/j.pnpbp.2018.04.007
   Fond G, 2016, PRESSE MED, V45, P7, DOI 10.1016/j.lpm.2015.10.016
   Fond G, 2014, EUR ARCH PSY CLIN N, V264, P651, DOI 10.1007/s00406-014-0502-z
   Godin O, 2017, J PSYCHIATR RES, V94, P62, DOI 10.1016/j.jpsychires.2017.06.008
   Godin O, 2015, SCHIZOPHR RES, V168, P388, DOI 10.1016/j.schres.2015.07.047
   Greenberg PE, 2015, J CLIN PSYCHIAT, V76, P155, DOI 10.4088/JCP.14m09298
   Gregoigi A, 2017, BRIT J PSYCHIAT, V211, P198, DOI 10.1192/bjp.bp.116.190520
   Hay S.I.
   Hocquart M, 2018, CLIN INFECT DIS, V66, P645, DOI 10.1093/cid/cix762
   Jiang HY, 2015, BRAIN BEHAV IMMUN, V48, P186, DOI 10.1016/j.bbi.2015.03.016
   Johnsen PH, 2018, LANCET GASTROENTEROL, V3, P17, DOI 10.1016/S2468-1253(17)30338-2
   Kao D, 2017, JAMA-J AM MED ASSOC, V318, P1985, DOI 10.1001/jama.2017.17077
   Kelly JR, 2016, J PSYCHIATR RES, V82, P109, DOI 10.1016/j.jpsychires.2016.07.019
   Kiecolt-Glaser JK, 2018, PSYCHONEUROENDOCRINO, V98, P52, DOI 10.1016/j.psyneuen.2018.08.007
   Kleiman SC, 2015, PSYCHOSOM MED, V77, P969, DOI 10.1097/PSY.0000000000000247
   Kucerova J, 2015, BIOMED PAP, V159, P208, DOI 10.5507/bp.2014.060
   Kump PK, 2014, CLIN MICROBIOL INFEC, V20, P1106, DOI 10.1111/1469-0691.12801
   Lagier JC, 2020, CLIN INFECT DIS, V70, P2454, DOI 10.1093/cid/ciz707
   Lagier JC, 2016, M S-MED SCI, V32, P991, DOI 10.1051/medsci/20163211015
   Li YT, 2016, ALIMENT PHARM THER, V43, P445, DOI 10.1111/apt.13492
   Lin P, 2017, J AFFECT DISORDERS, V207, P300, DOI 10.1016/j.jad.2016.09.051
   Liu RT, 2019, NEUROSCI BIOBEHAV R, V102, P13, DOI 10.1016/j.neubiorev.2019.03.023
   Liu YX, 2016, CLIN GASTROENTEROL H, V14, P1602, DOI 10.1016/j.cgh.2016.05.033
   Madan A, 2020, J AFFECT DISORDERS, V264, P98, DOI 10.1016/j.jad.2019.12.020
   Mason BL, 2020, J AFFECT DISORDERS, V266, P394, DOI 10.1016/j.jad.2020.01.137
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Nakajima S, 2015, SCHIZOPHR RES, V161, P429, DOI 10.1016/j.schres.2014.12.024
   Naseribafrouei A, 2014, NEUROGASTROENT MOTIL, V26, P1155, DOI 10.1111/nmo.12378
   Ng QX, 2019, NEUROPSYCHOBIOLOGY, V78, P1, DOI 10.1159/000498862
   Paramsothy S, 2017, LANCET, V389, P1218, DOI 10.1016/S0140-6736(17)30182-4
   Peter J, 2018, PSYCHOSOM MED, V80, P698, DOI [10.1097/PSY.0000000000000630, 10.1097/psy.0000000000000630]
   Rao K, 2017, JAMA-J AM MED ASSOC, V318, P1979, DOI 10.1001/jama.2017.17969
   Rodrigues-Amorim D, 2018, WORLD J BIOL PSYCHIA, V19, P571, DOI 10.1080/15622975.2018.1433878
   Rook GAW, 2014, ADV EXP MED BIOL, V817, P319, DOI 10.1007/978-1-4939-0897-4_15
   Rowland LM, 2017, FRONT PSYCHIATRY, V8, DOI 10.3389/fpsyt.2017.00104
   Schwarz E, 2018, SCHIZOPHR RES, V192, P398, DOI 10.1016/j.schres.2017.04.017
   Severance EG, 2015, CURR PSYCHIAT REP, V17, DOI 10.1007/s11920-015-0574-0
   Severance EG, 2013, SCHIZOPHR RES, V148, P130, DOI 10.1016/j.schres.2013.05.018
   Shen Y, 2018, SCHIZOPHR RES, V197, P470, DOI 10.1016/j.schres.2018.01.002
   Sobocki P, 2006, J MENT HEALTH POLICY, V9, P87
   Staley C, 2017, AM J GASTROENTEROL, V112, P940, DOI 10.1038/ajg.2017.6
   van Nood E, 2013, NEW ENGL J MED, V368, P2145, DOI [10.1056/NEJMoa1205037, 10.1056/NEJMc1303919]
   Wang SA, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0161174
   WHO, 2012, Depression: A global crisis. World mental health day
   Wykes T, 2015, LANCET PSYCHIAT, V2, P1036, DOI 10.1016/S2215-0366(15)00332-6
   Zhu XQ, 2017, ONCOTARGET, V8, P53829, DOI 10.18632/oncotarget.17754
NR 68
TC 40
Z9 43
U1 3
U2 52
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2020
VL 12
IS 4
AR 1024
DI 10.3390/nu12041024
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA LL8VE
UT WOS:000531831300144
PM 32276499
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Psaltopoulou, T
   Sergentanis, TN
   Panagiotakos, DB
   Sergentanis, IN
   Kosti, R
   Scarmeas, N
AF Psaltopoulou, Theodora
   Sergentanis, Theodoros N.
   Panagiotakos, Demosthenes B.
   Sergentanis, Ioannis N.
   Kosti, Rena
   Scarmeas, Nikolaos
TI Mediterranean Diet, Stroke, Cognitive Impairment, and Depression: A
   Meta-Analysis
SO ANNALS OF NEUROLOGY
LA English
DT Article
ID CARDIOVASCULAR-DISEASE RISK; PHYSICAL-ACTIVITY; MYOCARDIAL-INFARCTION;
   ALZHEIMERS-DISEASE; METABOLIC SYNDROME; STYLE DIET; ADHERENCE;
   INFLAMMATION; PATTERNS; SYMPTOMS
AB ObjectiveThis meta-analysis aims to quantitatively synthesize all studies that examine the association between adherence to a Mediterranean diet and risk of stroke, depression, cognitive impairment, and Parkinson disease.
   MethodsPotentially eligible publications were those providing effect estimates of relative risk (RR) for the association between Mediterranean diet and the aforementioned outcomes. Studies were sought in PubMed up to October 31, 2012. Maximally adjusted effect estimates were extracted; separate analyses were performed for high and moderate adherence.
   ResultsTwenty-two eligible studies were included (11 covered stroke, 9 covered depression, and 8 covered cognitive impairment; only 1 pertained to Parkinson's disease). High adherence to Mediterranean diet was consistently associated with reduced risk for stroke (RR=0.71, 95% confidence interval [CI]=0.57-0.89), depression (RR=0.68, 95% CI=0.54-0.86), and cognitive impairment (RR=0.60, 95% CI=0.43-0.83). Moderate adherence was similarly associated with reduced risk for depression and cognitive impairment, whereas the protective trend concerning stroke was only marginal. Subgroup analyses highlighted the protective actions of high adherence in terms of reduced risk for ischemic stroke, mild cognitive impairment, dementia, and particularly Alzheimer disease. Meta-regression analysis indicated that the protective effects of Mediterranean diet in stroke prevention seemed more sizeable among males. Concerning depression, the protective effects of high adherence seemed independent of age, whereas the favorable actions of moderate adherence seemed to fade away with more advanced age.
   InterpretationAdherence to a Mediterranean diet may contribute to the prevention of a series of brain diseases; this may be of special value given the aging of Western societies. Ann Neurol 2013;74:580-591
C1 [Psaltopoulou, Theodora; Sergentanis, Theodoros N.; Sergentanis, Ioannis N.; Kosti, Rena] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece.
   [Panagiotakos, Demosthenes B.] Harokopio Univ, Dept Nutr & Dietet, Athens, Greece.
   [Sergentanis, Ioannis N.] Univ Hosp Geneva, Hosp Psychiat, Geneva, Switzerland.
   [Scarmeas, Nikolaos] Univ Athens, Sch Med, Dept Neurol, GR-11527 Athens, Greece.
   [Scarmeas, Nikolaos] Columbia Univ, Dept Neurol, New York, NY USA.
C3 National & Kapodistrian University of Athens; Athens Medical School;
   Harokopio University Athens; University of Geneva; Athens Medical
   School; National & Kapodistrian University of Athens; Columbia
   University
RP Psaltopoulou, T (corresponding author), Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, 75 M Asias Str, GR-11527 Athens, Greece.
EM tpsaltop@med.uoa.gr
RI Psaltopoulou, Theodora/AAA-6878-2020; Scarmeas, Nikolaos/AAD-2512-2020;
   Sergentanis, Theodoros/AAD-8303-2019; Panagiotakos,
   Demosthenes/K-8294-2019
OI Sergentanis, Theodoros N./0000-0002-9355-5528; Psaltopoulou,
   Theodora/0000-0002-1404-9716; Kosti, Rena/0000-0001-7915-6064
CR Agnoli C, 2011, J NUTR, V141, P1552, DOI 10.3945/jn.111.140061
   Antonogeorgos G, 2012, ANN EPIDEMIOL, V22, P630, DOI 10.1016/j.annepidem.2012.06.103
   Appleton KM, 2010, AM J CLIN NUTR, V91, P757, DOI 10.3945/ajcn.2009.28313
   Bach-Faig A, 2011, PUBLIC HEALTH NUTR, V14, P2274, DOI 10.1017/S1368980011002515
   Bountziouka V, 2009, J AGING HEALTH, V21, P864, DOI 10.1177/0898264309340693
   Carter SJ, 2010, ATHEROSCLEROSIS, V210, P630, DOI 10.1016/j.atherosclerosis.2009.12.035
   Cherbuin N, 2012, AM J GERIAT PSYCHIAT, V20, P635, DOI 10.1097/JGP.0b013e31823032a9
   Chrysohoou C, 2004, J AM COLL CARDIOL, V44, P152, DOI 10.1016/j.jacc.2004.03.039
   Chrysohoou C, 2010, CARDIOL RES PRACT, V2011
   Chrysohoou C, 2011, MATURITAS, V70, P58, DOI 10.1016/j.maturitas.2011.06.003
   Dai J, 2008, AM J CLIN NUTR, V88, P1364, DOI 10.3945/ajcn.2008.26528
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   Esposito K, 2011, METAB SYNDR RELAT D, V9, P1, DOI 10.1089/met.2010.0031
   Estruch R, 2013, NEW ENGL J MED, V368, P1279, DOI 10.1056/NEJMoa1200303
   European Food Safety Authority, 2011, EFSA J, V9, P2245
   Féart C, 2009, JAMA-J AM MED ASSOC, V302, P638, DOI 10.1001/jama.2009.1146
   Fragopoulou E, 2010, J NUTR BIOCHEM, V21, P285, DOI 10.1016/j.jnutbio.2008.12.013
   Fung TT, 2009, CIRCULATION, V119, P1093, DOI 10.1161/CIRCULATIONAHA.108.816736
   Gao X, 2007, AM J CLIN NUTR, V86, P1486, DOI 10.1093/ajcn/86.5.1486
   Gardener H, 2012, ARCH NEUROL-CHICAGO, V69, P251, DOI 10.1001/archneurol.2011.548
   Gardener H, 2011, AM J CLIN NUTR, V94, P1458, DOI 10.3945/ajcn.111.012799
   Gardener S, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.91
   Gu Y, 2011, CURR ALZHEIMER RES, V8, P510, DOI 10.2174/156720511796391836
   Higgins J, 2011, AM J PUBLIC HEALTH, V5, P1
   Hoevenaar-Blom MP, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0045458
   Kastorini CM, 2011, AM HEART J, V162, P717, DOI 10.1016/j.ahj.2011.07.012
   Kastorini CM, 2011, J AM COLL CARDIOL, V57, P1299, DOI 10.1016/j.jacc.2010.09.073
   Knopman DS, 2009, JAMA-J AM MED ASSOC, V302, P686, DOI 10.1001/jama.2009.1149
   Llorente-Cortés V, 2010, ATHEROSCLEROSIS, V208, P442, DOI 10.1016/j.atherosclerosis.2009.08.004
   Luciano M, 2012, BRAIN BEHAV IMMUN, V26, P717, DOI 10.1016/j.bbi.2011.10.007
   Martínez-González MA, 2012, J NUTR, V142, P1672, DOI 10.3945/jn.112.162891
   McMillan L, 2011, APPETITE, V56, P143, DOI 10.1016/j.appet.2010.11.149
   Milaneschi Y, 2011, MOL PSYCHIATR, V16, P589, DOI 10.1038/mp.2010.113
   Mullan RJ, 2009, J CLIN EPIDEMIOL, V62, P138, DOI 10.1016/j.jclinepi.2008.08.002
   Ownby RL, 2006, ARCH GEN PSYCHIAT, V63, P530, DOI 10.1001/archpsyc.63.5.530
   Panagiotakos DB, 2006, NUTR METAB CARDIOVAS, V16, P559, DOI 10.1016/j.numecd.2005.08.006
   Panagiotakos DB, 2009, INT J EPIDEMIOL, V38, P856, DOI 10.1093/ije/dyp142
   Psaltopoulou T, 2008, PUBLIC HEALTH NUTR, V11, P1054, DOI 10.1017/S1368980007001607
   Psaltopoulou T, 2004, AM J CLIN NUTR, V80, P1012, DOI 10.1093/ajcn/80.4.1012
   Roberts RO, 2010, DEMENT GERIATR COGN, V29, P413, DOI 10.1159/000305099
   Romaguera D, 2011, DIABETES CARE, V34, P1913, DOI 10.2337/dc11-0891
   Sánchez-Villegas A, 2009, ARCH GEN PSYCHIAT, V66, P1090, DOI 10.1001/archgenpsychiatry.2009.129
   Scarmeas N, 2011, ANN NEUROL, V69, P257, DOI 10.1002/ana.22317
   Scarmeas N, 2009, JAMA-J AM MED ASSOC, V302, P627, DOI 10.1001/jama.2009.1144
   Scarmeas N, 2009, ARCH NEUROL-CHICAGO, V66, P216, DOI 10.1001/archneurol.2008.536
   Scarmeas N, 2006, ARCH NEUROL-CHICAGO, V63, P1709, DOI 10.1001/archneur.63.12.noc60109
   Sherzai A, 2012, NUTR REV, V70, P423, DOI 10.1111/j.1753-4887.2012.00490.x
   Sofi F, 2010, AM J CLIN NUTR, V92, P1189, DOI 10.3945/ajcn.2010.29673
   Sofi F, 2010, J ALZHEIMERS DIS, V20, P795, DOI 10.3233/JAD-2010-1418
   Sofi F, 2008, BMJ-BRIT MED J, V337, DOI 10.1136/bmj.a1344
   Solfrizzi V, 2011, CURR ALZHEIMER RES, V8, P520, DOI 10.2174/156720511796391809
   Stephan BCM, 2013, BMJ OPEN, V3, DOI 10.1136/bmjopen-2012-001909
   Stroup DF, 2000, JAMA-J AM MED ASSOC, V283, P2008, DOI 10.1001/jama.283.15.2008
   Tangney CC, 2011, AM J CLIN NUTR, V93, P601, DOI 10.3945/ajcn.110.007369
   TOMBAUGH TN, 1992, J AM GERIATR SOC, V40, P922, DOI 10.1111/j.1532-5415.1992.tb01992.x
   Trichopoulou A, 2005, BMJ-BRIT MED J, V330, P991, DOI 10.1136/bmj.38415.644155.8F
   Trichopoulou A, 2003, NEW ENGL J MED, V348, P2599, DOI 10.1056/NEJMoa025039
   UNESCO, INT HER LISTS MED DI
   Vercambre MN, 2012, J ACAD NUTR DIET, V112, P816, DOI 10.1016/j.jand.2012.02.023
   Vincent-Baudry S, 2005, AM J CLIN NUTR, V82, P964, DOI 10.1093/ajcn/82.5.964
   Willett WC, 2006, PUBLIC HEALTH NUTR, V9, P105, DOI 10.1079/PHN2005931
   Yau WY, 2011, J CLIN NEUROSCI, V18, P76, DOI 10.1016/j.jocn.2010.05.014
NR 62
TC 593
Z9 643
U1 5
U2 161
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-5134
EI 1531-8249
J9 ANN NEUROL
JI Ann. Neurol.
PD OCT
PY 2013
VL 74
IS 4
BP 580
EP 591
DI 10.1002/ana.23944
PG 12
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 257FN
UT WOS:000327369100012
PM 23720230
DA 2025-06-11
ER

PT J
AU Iozzo, P
   Holmes, M
   Schmidt, MV
   Cirulli, F
   Guzzardi, MA
   Berry, A
   Balsevich, G
   Andreassi, MG
   Wesselink, JJ
   Liistro, T
   Gómez-Puertas, P
   Eriksson, JG
   Seckl, J
AF Iozzo, Patricia
   Holmes, Megan
   Schmidt, Mathias V.
   Cirulli, Francesca
   Guzzardi, Maria Angela
   Berry, Alessandra
   Balsevich, Georgia
   Andreassi, Maria Grazia
   Wesselink, Jan-Jaap
   Liistro, Tiziana
   Gomez-Puertas, Paulino
   Eriksson, Johan G.
   Seckl, Jonathan
TI Developmental ORIgins of Healthy and Unhealthy AgeiNg: The Role of
   Maternal Obesity - Introduction to DORIAN
SO OBESITY FACTS
LA English
DT Article
DE Pregnancy; Foetal programming; Obesity; Diabetes; Cardiovascular
   disease; Stress; Oxidative damage; Insulin resistance; HSD2; p66
ID HIGH-FAT DIET; ANXIETY-LIKE BEHAVIOR; TYPE-2 11-BETA-HYDROXYSTEROID
   DEHYDROGENASE; BETA-HYDROXYSTEROID DEHYDROGENASE; PRENATAL DEXAMETHASONE
   EXPOSURE; PITUITARY-ADRENAL-AXIS; LOW-CARBOHYDRATE DIET; METABOLIC
   SYNDROME; INSULIN-RESISTANCE; TELOMERE LENGTH
AB Europe has the highest proportion of elderly people in the world. Cardiovascular disease, type 2 diabetes, sarcopenia and cognitive decline frequently coexist in the same aged individual, sharing common early risk factors and being mutually reinforcing. Among conditions which may contribute to establish early risk factors, this review focuses on maternal obesity, since the epidemic of obesity involves an ever growing number of women of reproductive age and children, calling for appropriate studies to understand the consequences of maternal obesity on the offspring's health and for developing effective measures and policies to improve people's health before their conception and birth. Though the current knowledge suggests that the long-term impact of maternal obesity on the offspring's health may be substantial, the outcomes of maternal obesity over the lifespan have not been quantified, and the molecular changes induced by maternal obesity remain poorly characterized. We hypothesize that maternal insulin resistance and reduced placental glucocorticoid catabolism, leading to oxidative stress, may damage the DNA, either in its structure (telomere shortening) or in its function (via epigenetic changes), resulting in altered gene expression/repair, disease during life, and pathological ageing. This review illustrates the background to the EU-FP7-HEALTH-DORIAN project. (C) 2014 S. Karger GmbH, Freiburg
C1 [Iozzo, Patricia; Guzzardi, Maria Angela; Andreassi, Maria Grazia; Liistro, Tiziana] CNR, Inst Clin Physiol, I-56124 Pisa, Italy.
   [Cirulli, Francesca; Berry, Alessandra] Ist Super Sanita, I-00161 Rome, Italy.
   [Holmes, Megan; Seckl, Jonathan] Univ Edinburgh, Ctr Cardiovasc Sci, Endocrinol Unit, Edinburgh, Midlothian, Scotland.
   [Schmidt, Mathias V.; Balsevich, Georgia] Max Planck Inst Psychiat MPG, Munich, Germany.
   [Wesselink, Jan-Jaap; Gomez-Puertas, Paulino] Biomol Informat SL, Madrid, Spain.
   [Eriksson, Johan G.] Samfundet Folkhalsan Svenska Finland Rf Folkhalsa, Helsinki, Finland.
   [Eriksson, Johan G.] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto di Fisiologia Clinica
   (IFC-CNR); Istituto Superiore di Sanita (ISS); University of Edinburgh;
   Samfundet Folkhalsan; University of Helsinki
RP Iozzo, P (corresponding author), CNR, Inst Clin Physiol, Via Moruzzi 1, I-56124 Pisa, Italy.
EM patricia.iozzo@ifc.cnr.it
RI Cirulli, Francesca/H-5992-2019; Berry, Alessandra/N-9280-2017; Gibbs, J.
   Raphael/A-3984-2010; Gomez-Puertas, Paulino/G-8821-2014; Iozzo,
   Patricia/O-2893-2015; GUZZARDI, MARIAANGELA/K-1389-2016
OI Balsevich, Georgia/0000-0002-7839-018X; Berry,
   Alessandra/0000-0001-6562-9043; Eriksson, Johan/0000-0002-2516-2060;
   Andreassi, Maria Grazia/0000-0002-2163-0816; Schmidt,
   Mathias/0000-0002-3788-2268; CIRULLI, Francesca/0000-0001-9440-1873;
   Gomez-Puertas, Paulino/0000-0003-3131-729X; Iozzo,
   Patricia/0000-0001-6443-7074; GUZZARDI, MARIAANGELA/0000-0001-9574-5088
FU EU (FP7); Italian Ministry of Health (Italia-Usa Project) [11US/14/1];
   European Foundation for the Study of Diabetes (EFSD) [2009];  [278603]
FX Funding for the project is provided by EU (FP7) Project 'Developmental
   Origin of Healthy and Unhealthy Ageing: the Role of Maternal Obesity'
   (DORIAN) (grant n. 278603). Additional support was received by the
   Italian Ministry of Health (Italia-Usa Project), Fasc. 11US/14/1 (to
   FC), and the European Foundation for the Study of Diabetes (EFSD/Roche
   educational grant 2009, to PI).
CR Abraham NG, 2007, ANN NY ACAD SCI, V1113, P256, DOI 10.1196/annals.1391.015
   Al-Attas OS, 2010, ACTA PAEDIATR, V99, P896, DOI 10.1111/j.1651-2227.2010.01720.x
   Alikhani-Koopaei R, 2004, J CLIN INVEST, V114, P1146, DOI 10.1172/JCI200421647
   [Anonymous], SCI SIGNAL
   Armitage JA, 2004, J PHYSIOL-LONDON, V561, P355, DOI 10.1113/jphysiol.2004.072009
   Aufdenblatten M, 2009, PEDIATR RES, V65, P198, DOI 10.1203/PDR.0b013e31818d6c24
   Bailey TL, 2006, NUCLEIC ACIDS RES, V34, pW369, DOI 10.1093/nar/gkl198
   Bandyopadhyay D, 2003, EXP GERONTOL, V38, P1299, DOI 10.1016/j.exger.2003.09.009
   Barden N, 1996, PHARMACOPSYCHIATRY, V29, P12, DOI 10.1055/s-2007-979536
   Barker DJP, 2005, HORM RES, V64, P2, DOI 10.1159/000089311
   Barzilai N, 2012, DIABETES, V61, P1315, DOI 10.2337/db11-1300
   Bayram B, 2013, AGE, V35, P1205, DOI 10.1007/s11357-012-9448-0
   Beck B, 2012, FRONT PHYSIOL, V3, DOI 10.3389/fphys.2012.00224
   BENEDIKTSSON R, 1993, LANCET, V341, P339, DOI 10.1016/0140-6736(93)90138-7
   Berniakovich I, 2008, J BIOL CHEM, V283, P34283, DOI 10.1074/jbc.M804362200
   Berry A, 2008, EXP GERONTOL, V43, P200, DOI 10.1016/j.exger.2007.10.016
   Berry A, 2007, EXP GERONTOL, V42, P37, DOI 10.1016/j.exger.2006.05.018
   Berry A, 2012, HIPPOCAMPUS, V22, P2249, DOI 10.1002/hipo.22042
   Berry A, 2010, EXP GERONTOL, V45, P343, DOI 10.1016/j.exger.2010.01.010
   Bertram C, 2001, ENDOCRINOLOGY, V142, P2841, DOI 10.1210/en.142.7.2841
   Bilbo SD, 2010, FASEB J, V24, P2104, DOI 10.1096/fj.09-144014
   Biron-Shental T, 2011, EARLY HUM DEV, V87, P73, DOI 10.1016/j.earlhumdev.2010.08.024
   Boney CM, 2005, PEDIATRICS, V115, pE290, DOI 10.1542/peds.2004-1808
   Botto N, 2005, MUTAT RES-FUND MOL M, V570, P81, DOI 10.1016/j.mrfmmm.2004.10.003
   Branth S, 2007, NUTR METAB CARDIOVAS, V17, P427, DOI 10.1016/j.numecd.2006.03.001
   Buxton JL, 2011, J CLIN ENDOCR METAB, V96, P1500, DOI 10.1210/jc.2010-2924
   Calvert JW, 2009, EXP PHYSIOL, V94, P805, DOI 10.1113/expphysiol.2009.047183
   Cassidy A, 2010, AM J CLIN NUTR, V91, P1273, DOI 10.3945/ajcn.2009.28947
   Catalano PM, 2006, BJOG-INT J OBSTET GY, V113, P1126, DOI 10.1111/j.1471-0528.2006.00989.x
   Catalano PM, 2012, DIABETES CARE, V35, P780, DOI 10.2337/dc11-1790
   Catalano PM, 2010, REPRODUCTION, V140, P365, DOI 10.1530/REP-10-0088
   Catalano PM, 2009, AM J CLIN NUTR, V90, P1303, DOI 10.3945/ajcn.2008.27416
   Catalano PM, 2009, DIABETES CARE, V32, P1076, DOI 10.2337/dc08-2077
   Catalano PM, 1998, DIABETES CARE, V21, pB85
   Cedergren MI, 2004, OBSTET GYNECOL, V103, P219, DOI 10.1097/01.AOG.0000107291.46159.00
   Challier JC, 2008, PLACENTA, V29, P274, DOI 10.1016/j.placenta.2007.12.010
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Charney Dennis S, 2004, Sci STKE, V2004, pre5, DOI 10.1126/stke.2252004re5
   Chrousos GP, 1998, ANN NY ACAD SCI, V851, P311, DOI 10.1111/j.1749-6632.1998.tb09006.x
   CORRALDEBRINSKI M, 1992, MUTAT RES, V275, P169, DOI 10.1016/0921-8734(92)90021-G
   Cottrell EC, 2012, FASEB J, V26, P1866, DOI 10.1096/fj.12-203489
   Cross JA, 2010, DIABETIC MED, V27, P1264, DOI 10.1111/j.1464-5491.2010.03099.x
   Dabelea D, 2011, DIABETES, V60, P1849, DOI 10.2337/db11-0400
   Dallman MF, 2010, TRENDS ENDOCRIN MET, V21, P159, DOI 10.1016/j.tem.2009.10.004
   Das S, 2010, METAB SYNDR RELAT D, V8, P25, DOI 10.1089/met.2009.0017
   Dave-Sharma S, 1998, J CLIN ENDOCR METAB, V83, P2244, DOI 10.1210/jc.83.7.2244
   Davy P, 2009, PLACENTA, V30, P539, DOI 10.1016/j.placenta.2009.03.005
   de Kloet ER, 2005, NAT REV NEUROSCI, V6, P463, DOI 10.1038/nrn1683
   de Vries A, 2007, J CLIN INVEST, V117, P1058, DOI 10.1172/JCI30982
   Dortland AKBV, 2010, ACTA PSYCHIAT SCAND, V122, P30, DOI 10.1111/j.1600-0447.2010.01565.x
   Drake AJ, 2005, AM J PHYSIOL-REG I, V288, pR34, DOI 10.1152/ajpregu.00106.2004
   Drake AJ, 2012, CLIN ENDOCRINOL, V77, P808, DOI 10.1111/j.1365-2265.2012.04453.x
   Drake AJ, 2011, EPIGENETICS-US, V6, P1334, DOI 10.4161/epi.6.11.17942
   Drake AJ, 2010, REPRODUCTION, V140, P387, DOI 10.1530/REP-10-0077
   Dunn GA, 2009, ENDOCRINOLOGY, V150, P4999, DOI 10.1210/en.2009-0500
   EDWARDS CRW, 1993, LANCET, V341, P355, DOI 10.1016/0140-6736(93)90148-A
   Engum A, 2007, J PSYCHOSOM RES, V62, P31, DOI 10.1016/j.jpsychores.2006.07.009
   Entringer S, 2011, P NATL ACAD SCI USA, V108, pE513, DOI 10.1073/pnas.1107759108
   Epel ES, 2004, P NATL ACAD SCI USA, V101, P17312, DOI 10.1073/pnas.0407162101
   Fadini GP, 2011, AGING CELL, V10, P10, DOI 10.1111/j.1474-9726.2010.00642.x
   Faith MS, 2002, J PSYCHOSOM RES, V53, P935, DOI 10.1016/S0022-3999(02)00308-2
   FOLSOM AR, 1993, JAMA-J AM MED ASSOC, V269, P483, DOI 10.1001/jama.269.4.483
   Foster MT, 2009, ENDOCRINOLOGY, V150, P2325, DOI 10.1210/en.2008-1426
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gallagher P, 2007, SCHIZOPHR RES, V90, P258, DOI 10.1016/j.schres.2006.11.020
   Giorgio M, 2012, AGING CELL, V11, P162, DOI 10.1111/j.1474-9726.2011.00770.x
   Gluckman PD, 2008, INT J OBESITY, V32, pS62, DOI 10.1038/ijo.2008.240
   Gluckman PD, 2008, NEW ENGL J MED, V359, P61, DOI 10.1056/NEJMra0708473
   Godfrey KM, 2011, DIABETES, V60, P1528, DOI 10.2337/db10-0979
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Gorska E, 2010, EUR J MED RES, V15, P50
   Guiducci L, 2011, J NUCL MED, V52, P1993, DOI 10.2967/jnumed.111.087882
   Guzmán C, 2006, J PHYSIOL-LONDON, V572, P97, DOI 10.1113/jphysiol.2005.103903
   Haffner S, 2003, CIRCULATION, V108, P1541, DOI 10.1161/01.CIR.0000088845.17586.EC
   Haussmann MF, 2012, P ROY SOC B-BIOL SCI, V279, P1447, DOI 10.1098/rspb.2011.1913
   Herrick K, 2003, J CLIN ENDOCR METAB, V88, P3554, DOI 10.1210/jc.2003-030287
   Heyn H, 2012, EPIGENETICS-US, V7, P542, DOI 10.4161/epi.20523
   HOFFMAN EC, 1983, J ANIM SCI, V57, P609, DOI 10.2527/jas1983.573609x
   Holmes MC, 2006, J NEUROSCI, V26, P3840, DOI 10.1523/JNEUROSCI.4464-05.2006
   Holsboer F, 2000, NEUROPSYCHOPHARMACOL, V23, P477, DOI 10.1016/S0893-133X(00)00159-7
   Holsboer F, 1996, ENDOCR REV, V17, P187, DOI 10.1210/er.17.2.187
   Holsboer F, 2010, ANNU REV PSYCHOL, V61, P81, DOI 10.1146/annurev.psych.093008.100321
   Holzenberger M, 2003, NATURE, V421, P182, DOI 10.1038/nature01298
   HOTAMISLIGIL GS, 1994, P NATL ACAD SCI USA, V91, P4854, DOI 10.1073/pnas.91.11.4854
   Huang J, 2012, BIOINFORMATICS, V28, P587, DOI 10.1093/bioinformatics/btr699
   Jennings BJ, 1999, FEBS LETT, V448, P4, DOI 10.1016/S0014-5793(99)00336-1
   Jensen E, 2007, PLACENTA, V28, P658, DOI 10.1016/j.placenta.2006.09.005
   Kajantie E, 2003, J CLIN ENDOCR METAB, V88, P493, DOI 10.1210/jc.2002-021378
   KENYON C, 1993, NATURE, V366, P461, DOI 10.1038/366461a0
   Khan LY, 2003, HYPERTENSION, V41, P168, DOI 10.1161/01.HYP.0000047511.97879.FC
   Khorram NM, 2011, REPROD SCI, V18, P931, DOI 10.1177/1933719111404613
   Kim SY, 2007, OBESITY, V15, P986, DOI 10.1038/oby.2007.621
   Kimura KD, 1997, SCIENCE, V277, P942, DOI 10.1126/science.277.5328.942
   Kirwan JP, 2002, DIABETES, V51, P2207, DOI 10.2337/diabetes.51.7.2207
   Kitanaka S, 1996, CLIN ENDOCRINOL, V44, P353, DOI 10.1046/j.1365-2265.1996.677500.x
   Kotelevtsev Y, 1999, J CLIN INVEST, V103, P683, DOI 10.1172/JCI4445
   LABORDE JB, 1992, FUND APPL TOXICOL, V19, P545, DOI 10.1016/0272-0590(92)90093-W
   LangleyEvans SC, 1996, PLACENTA, V17, P169, DOI 10.1016/S0143-4004(96)80010-5
   Lesage J, 2001, ENDOCRINOLOGY, V142, P1692, DOI 10.1210/en.142.5.1692
   Li H, 2009, BIOINFORMATICS, V25, P1754, DOI [10.1093/bioinformatics/btp324, 10.1093/bioinformatics/btp352, 10.1093/bioinformatics/btp698]
   Li KQK, 2013, ANTI-CANCER AGENT ME, V13, P242
   Lillycrop KA, 2005, J NUTR, V135, P1382, DOI 10.1093/jn/135.6.1382
   Lillycrop KA, 2008, BRIT J NUTR, V100, P278, DOI 10.1017/S0007114507894438
   Lin PH, 2003, FREE RADICAL BIO MED, V35, P1310, DOI 10.1016/j.freeradbiomed.2003.07.002
   Lindsay RS, 1996, HYPERTENSION, V27, P1200, DOI 10.1161/01.HYP.27.6.1200
   Lindsay RS, 1996, DIABETOLOGIA, V39, P1299, DOI 10.1007/s001250050573
   Longo VD, 2003, SCIENCE, V299, P1342, DOI 10.1126/science.1077991
   Martorell R, 2001, J NUTR, V131, p874S, DOI 10.1093/jn/131.3.874S
   Meaburn E, 2012, SEMIN CELL DEV BIOL, V23, P192, DOI 10.1016/j.semcdb.2011.10.010
   Migliaccio E, 1999, NATURE, V402, P309, DOI 10.1038/46311
   Monickaraj F, 2012, CLIN BIOCHEM, V45, P1432, DOI 10.1016/j.clinbiochem.2012.07.097
   Morley JE, 2008, CLIN GERIATR MED, V24, P395, DOI 10.1016/j.cger.2008.03.005
   Mueller BR, 2008, J NEUROSCI, V28, P9055, DOI 10.1523/JNEUROSCI.1424-08.2008
   Mueller BR, 2006, PHYSIOL BEHAV, V88, P605, DOI 10.1016/j.physbeh.2006.05.019
   Muller M, 2010, NEUROEPIDEMIOLOGY, V34, P83, DOI 10.1159/000264825
   MUNE T, 1995, NAT GENET, V10, P394, DOI 10.1038/ng0895-394
   Murabayashi N, 2013, EUR J OBSTET GYN R B, V169, P39, DOI 10.1016/j.ejogrb.2013.02.003
   Murgatroyd C, 2009, NAT NEUROSCI, V12, P1559, DOI 10.1038/nn.2436
   Murphy VE, 2002, J CLIN ENDOCR METAB, V87, P1660, DOI 10.1210/jc.87.4.1660
   Naef L, 2011, NEUROSCIENCE, V176, P225, DOI 10.1016/j.neuroscience.2010.12.037
   Naef L, 2008, PSYCHOPHARMACOLOGY, V197, P83, DOI 10.1007/s00213-007-1008-4
   Nagano M, 2008, NEUROSCI RES, V60, P364, DOI 10.1016/j.neures.2007.12.005
   Newnham JP, 2009, SEMIN FETAL NEONAT M, V14, P157, DOI 10.1016/j.siny.2008.11.005
   Nieuwenhuizen AG, 2008, PHYSIOL BEHAV, V94, P169, DOI 10.1016/j.physbeh.2007.12.011
   Njajou OT, 2012, INT J OBESITY, V36, P1176, DOI 10.1038/ijo.2011.196
   Nyirenda MJ, 2006, DIABETOLOGIA, V49, P1412, DOI 10.1007/s00125-006-0188-5
   Nyirenda MJ, 1998, J CLIN INVEST, V101, P2174, DOI 10.1172/JCI1567
   Nyirenda MJ, 2009, DIABETES, V58, P2873, DOI 10.2337/db09-0873
   O'Donnell KJ, 2012, PSYCHONEUROENDOCRINO, V37, P818, DOI 10.1016/j.psyneuen.2011.09.014
   O'Regan D, 2004, AM J PHYSIOL-ENDOC M, V287, pE863, DOI 10.1152/ajpendo.00137.2004
   Okuda K, 2002, PEDIATR RES, V52, P377, DOI 10.1203/01.PDR.0000022341.72856.72
   Owens LA, 2010, DIABETES CARE, V33, P577, DOI 10.2337/dc09-0911
   Park LK, 2012, P NUTR SOC, V71, P75, DOI 10.1017/S0029665111003302
   PETTITT D J, 1988, Journal of Obesity and Weight Regulation, V7, P61
   Pirkola J, 2010, DIABETES CARE, V33, P1115, DOI 10.2337/dc09-1871
   Pirkola J, 2010, J CLIN ENDOCR METAB, V95, P772, DOI 10.1210/jc.2009-1075
   Portela A, 2010, NAT BIOTECHNOL, V28, P1057, DOI 10.1038/nbt.1685
   Price LH, 2013, BIOL PSYCHIAT, V73, P15, DOI 10.1016/j.biopsych.2012.06.025
   Raffaitin C, 2011, NEUROLOGY, V76, P518, DOI 10.1212/WNL.0b013e31820b7656
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Räikkönen K, 2010, PSYCHONEUROENDOCRINO, V35, P1587, DOI 10.1016/j.psyneuen.2010.04.010
   Räikkönen K, 2009, AM J EPIDEMIOL, V170, P1137, DOI 10.1093/aje/kwp272
   Relton CL, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031821
   Reynolds RM, 2007, J CLIN ENDOCR METAB, V92, P2208, DOI 10.1210/jc.2007-0071
   Rosengren A, 2004, LANCET, V364, P953, DOI 10.1016/S0140-6736(04)17019-0
   Rosmond R, 2000, MED HYPOTHESES, V54, P990, DOI 10.1054/mehy.1999.1005
   RYAN EA, 1988, J CLIN ENDOCR METAB, V67, P341, DOI 10.1210/jcem-67-2-341
   Sahin E, 2012, NAT REV MOL CELL BIO, V13, P397, DOI 10.1038/nrm3352
   Samuelsson AM, 2008, HYPERTENSION, V51, P383, DOI 10.1161/HYPERTENSIONAHA.107.101477
   Sandovici I, 2011, P NATL ACAD SCI USA, V108, P5449, DOI 10.1073/pnas.1019007108
   Schaefer-Graf UM, 2008, DIABETES CARE, V31, P1858, DOI 10.2337/dc08-0039
   Schmidt MV, 2006, J NEUROENDOCRINOL, V18, P865, DOI 10.1111/j.1365-2826.2006.01482.x
   Scholl Theresa O, 2002, Matern Child Health J, V6, P255, DOI 10.1023/A:1021162117177
   Seckl JR, 2007, PROG BRAIN RES, V167, P17, DOI 10.1016/S0079-6123(07)67002-2
   Sepe A, 2011, GERONTOLOGY, V57, P66, DOI 10.1159/000279755
   Serre D, 2010, NUCLEIC ACIDS RES, V38, P391, DOI 10.1093/nar/gkp992
   Sewell MF, 2006, AM J OBSTET GYNECOL, V195, P1100, DOI 10.1016/j.ajog.2006.06.014
   Shiell AW, 2001, HYPERTENSION, V38, P1282, DOI 10.1161/hy1101.095332
   Simmons R, 2008, SEMIN PERINATOL, V32, P371, DOI 10.1053/j.semperi.2008.08.004
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Smith JT, 2000, ENDOCRINOLOGY, V141, P2422, DOI 10.1210/en.141.7.2422
   Song ZF, 2010, AGING CELL, V9, P607, DOI 10.1111/j.1474-9726.2010.00583.x
   Stewart PM, 1995, J STEROID BIOCHEM, V55, P465, DOI 10.1016/0960-0760(95)00195-6
   Stocker C, 2004, INT J OBESITY, V28, P129, DOI 10.1038/sj.ijo.0802476
   Sullivan EL, 2011, NEUROENDOCRINOLOGY, V93, P1, DOI 10.1159/000322038
   Sullivan EL, 2010, J NEUROSCI, V30, P3826, DOI 10.1523/JNEUROSCI.5560-09.2010
   Tamashiro KLK, 2011, ANN NY ACAD SCI, V1231, P46, DOI 10.1111/j.1749-6632.2011.06134.x
   Tamashiro KLK, 2009, DIABETES, V58, P1116, DOI 10.2337/db08-1129
   Tarry-Adkins JL, 2008, FASEB J, V22, P2037, DOI 10.1096/fj.07-099523
   Tarry-Adkins JL, 2009, FASEB J, V23, P1521, DOI 10.1096/fj.08-122796
   Tatar M, 2001, SCIENCE, V292, P107, DOI 10.1126/science.1057987
   Toker S, 2008, DEPRESS ANXIETY, V25, P661, DOI 10.1002/da.20379
   Tozuka Y, 2010, NEUROCHEM INT, V57, P235, DOI 10.1016/j.neuint.2010.05.015
   Treiber N, 2011, AGING CELL, V10, P239, DOI 10.1111/j.1474-9726.2010.00658.x
   Trottier G, 1998, ENDOCRINOLOGY, V139, P3704, DOI 10.1210/en.139.9.3704
   Valdes AM, 2005, LANCET, V366, P662, DOI 10.1016/S0140-6736(05)66630-5
   Viinamäki H, 2009, ACTA PSYCHIAT SCAND, V120, P23, DOI 10.1111/j.1600-0447.2008.01333.x
   Vucetic Z, 2010, ENDOCRINOLOGY, V151, P4756, DOI 10.1210/en.2010-0505
   Waddell BJ, 2000, BIOL REPROD, V63, P1913, DOI 10.1095/biolreprod63.6.1913
   Walker CD, 2008, ANN NY ACAD SCI, V1144, P189, DOI 10.1196/annals.1418.023
   Wang JY, 2010, FASEB J, V24, P2066, DOI 10.1096/fj.09-142315
   Waterland RA, 2003, MOL CELL BIOL, V23, P5293, DOI 10.1128/MCB.23.15.5293-5300.2003
   Weaver ICG, 2002, ENDOCR RES, V28, P699, DOI 10.1081/ERC-120016989
   Weaver ICG, 2004, NAT NEUROSCI, V7, P847, DOI 10.1038/nn1276
   Welberg LAM, 2000, EUR J NEUROSCI, V12, P1047, DOI 10.1046/j.1460-9568.2000.00958.x
   Welberg LAM, 2001, NEUROSCIENCE, V104, P71, DOI 10.1016/S0306-4522(01)00065-3
   Whitaker RC, 2004, PEDIATRICS, V114, pE29, DOI 10.1542/peds.114.1.e29
   Whorwood CB, 2001, ENDOCRINOLOGY, V142, P2854, DOI 10.1210/en.142.7.2854
   Wright T, 2011, PHYSIOL BEHAV, V103, P164, DOI 10.1016/j.physbeh.2011.01.008
   Wu GY, 2004, J NUTR, V134, P2169, DOI 10.1093/jn/134.9.2169
   Wyrwoll CS, 2007, HYPERTENSION, V50, P579, DOI 10.1161/HYPERTENSIONAHA.107.091603
   Wyrwoll CS, 2012, NEUROENDOCRINOLOGY, V95, P47, DOI 10.1159/000331345
   Wyrwoll CS, 2009, ENDOCRINOLOGY, V150, P1287, DOI 10.1210/en.2008-1100
   Wyrwoll CS, 2006, ENDOCRINOLOGY, V147, P599, DOI 10.1210/en.2005-0748
   Yajnik CS, 2009, INT J GYNECOL OBSTET, V104, pS27, DOI 10.1016/j.ijgo.2008.11.034
   Yan X, 2011, BIOL REPROD, V85, P172, DOI 10.1095/biolreprod.110.089649
   Yehuda R, 2009, J PSYCHIATR RES, V43, P877, DOI 10.1016/j.jpsychires.2008.12.003
   Zannolli R, 2008, ACTA PAEDIATR, V97, P952, DOI 10.1111/j.1651-2227.2008.00783.x
   Zeugmann S, 2010, J CLIN PSYCHIAT, V71, P1007, DOI 10.4088/JCP.08m04767blu
   Zhu MJ, 2008, J PHYSIOL-LONDON, V586, P2651, DOI 10.1113/jphysiol.2007.149633
NR 200
TC 23
Z9 25
U1 0
U2 32
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1662-4025
EI 1662-4033
J9 OBESITY FACTS
JI Obes. Facts
PD APR
PY 2014
VL 7
IS 2
BP 130
EP 151
DI 10.1159/000362656
PG 22
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA AH2NF
UT WOS:000335957500007
PM 24801105
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Parto, P
   Lavie, CJ
AF Parto, Parham
   Lavie, Carl J.
TI Obesity and Cardiovascular Diseases
SO CURRENT PROBLEMS IN CARDIOLOGY
LA English
DT Review
ID BODY-MASS INDEX; CORONARY-ARTERY-DISEASE; ALL-CAUSE MORTALITY;
   DENSITY-LIPOPROTEIN CHOLESTEROL; LEFT-VENTRICULAR MASS;
   CARDIORESPIRATORY FITNESS; ATRIAL-FIBRILLATION; RISK-FACTORS; METABOLIC
   SYNDROME; HEART-FAILURE
AB Obesity has reached epidemic proportions both in the United States and worldwide. There are numerous adverse effects on cardiac structure, hemodynamics, and cellular abnormalities, as well as increases in cardiovascular disease (CVD) risk factors such as hypertension, coronary heart disease, dyslipidemia, atrial fibrillation, and depression. Despite these overwhelming findings, large amounts of evidence support the presence of an "obesity paradox," where obese patients with CVD have a better prognosis than do lean or normal weight in patients with CVD. This review discusses the role of obesity in CVD risk factors and the implications of the obesity paradox in this subset of patients.
RI Lavie, Carl/A-6014-2011
CR Abed HS, 2013, HEART RHYTHM, V10, P90, DOI 10.1016/j.hrthm.2012.08.043
   Alexander JK, 1998, HEART AND LUNG IN OBESITY, P45
   Alpert M.A., 2014, Transl. Res
   Alpert MA, 1998, HEART AND LUNG IN OBESITY, P25
   Alpert MA, 2001, AM J MED SCI, V321, P225, DOI 10.1097/00000441-200104000-00003
   ALPERT MA, 1995, AM J CARDIOL, V76, P1194, DOI 10.1016/S0002-9149(99)80338-5
   ANDERSON KM, 1987, JAMA-J AM MED ASSOC, V257, P2176, DOI 10.1001/jama.257.16.2176
   Archer E, 2016, CURR PROB CARDIOLOGY, V41, P268, DOI 10.1016/j.cpcardiol.2016.10.007
   Artero EG, 2011, J AM COLL CARDIOL, V57, P1831, DOI 10.1016/j.jacc.2010.12.025
   Aune D, 2016, CIRCULATION, V115
   Aurigemma GP, 2013, CIRC-CARDIOVASC IMAG, V6, P142, DOI 10.1161/CIRCIMAGING.111.964627
   BENJAMIN EJ, 1994, JAMA-J AM MED ASSOC, V271, P840, DOI 10.1001/jama.271.11.840
   Blaine B, 2008, J HEALTH PSYCHOL, V13, P1190, DOI 10.1177/1359105308095977
   Blair SN, 1996, JAMA-J AM MED ASSOC, V276, P205, DOI 10.1001/jama.276.3.205
   Bornstein SR, 2006, MOL PSYCHIATR, V11, P892, DOI 10.1038/sj.mp.4001873
   Brinton D.G., 1870, Personal Beauty: How to Cultivate and Preserve It in Accordance with the Laws of Health
   Calori G, 2010, DIAB CARE, V34
   Charlson FJ, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-47
   Church T, 2015, CLIN LIPIDOLOGY COMP
   Cinti S, J LIPID RES AM SOC B
   Clark DM, 1997, J AM COLL CARDIOL, V30, P1039, DOI 10.1016/S0735-1097(97)00254-4
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Coutinho T, 2013, J AM COLL CARDIOL, V61, P553, DOI 10.1016/j.jacc.2012.10.035
   Coutinho T, 2011, J AM COLL CARDIOL, V57, P1877, DOI 10.1016/j.jacc.2010.11.058
   Cui YD, 2001, ARCH INTERN MED, V161, P1413, DOI 10.1001/archinte.161.11.1413
   Cullen P, 2000, AM J CARDIOL, V86, P943, DOI 10.1016/S0002-9149(00)01127-9
   De Schutter A, 2014, PROG CARDIOVASC DIS, V56, P401, DOI 10.1016/j.pcad.2013.08.003
   Eckel RH, 2014, J AM COLL CARDIOL, V63, P2960, DOI 10.1016/j.jacc.2013.11.003
   Elderon L, 2013, PROG CARDIOVASC DIS, V55, P511, DOI 10.1016/j.pcad.2013.03.010
   Ernstsen L, 2016, AM J MED, V129, P82, DOI 10.1016/j.amjmed.2015.08.012
   Fan JY, 2013, INT J CARDIOL, V168, P4761, DOI 10.1016/j.ijcard.2013.07.230
   Feingold KR, 2010, J LIPID RES, V51, P682, DOI 10.1194/jlr.E005454
   Feingold KR, 2000, Cholesterol Lowering Drugs
   Flegal KM, 2013, JAMA-J AM MED ASSOC, V309, P71, DOI 10.1001/jama.2012.113905
   Gelber RP, 2007, AM J HYPERTENS, V20, P370, DOI 10.1016/j.amjhyper.2006.10.011
   Gordon S, 2003, NAT REV IMMUNOL, V3, P23, DOI 10.1038/nri978
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Grundy SM, 2004, CIRCULATION, V110, P227, DOI 10.1161/01.CIR.0000133317.49796.0E
   Halverstadt A, 2007, METABOLISM, V56, P444, DOI 10.1016/j.metabol.2006.10.019
   Hatem SN, 2015, J AM COLL CARDIOL, V66, P12, DOI 10.1016/j.jacc.2015.04.057
   Hauck A, 2016, CIRCULATION S1, V134
   Hausman DB, OBES REV
   HIRSCH J, 1976, CLIN ENDOCRINOL META, V5, P299, DOI 10.1016/S0300-595X(76)80023-0
   HSUEH WA, 1994, ENDOCRIN METAB CLIN, V23, P405, DOI 10.1016/S0889-8529(18)30105-1
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Kachur S, 2016, AM J MED, V129, P1316, DOI 10.1016/j.amjmed.2016.07.006
   Katzmarzyk PT, 2005, DIABETES CARE, V28, P391, DOI 10.2337/diacare.28.2.391
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Lara-Castro C, 2007, CURR OPIN LIPIDOL, V18, P263, DOI 10.1097/MOL.0b013e32814a645f
   LAUER MS, 1991, JAMA-J AM MED ASSOC, V266, P231, DOI 10.1001/jama.266.2.231
   Lavie CJ, 2016, CAN J CARDIOL, V32, pS365, DOI 10.1016/j.cjca.2016.07.508
   Lavie CJ, 2016, PROG CARDIOVASC DIS, V58, P537, DOI 10.1016/j.pcad.2016.01.008
   Lavie CJ, 2015, HEART, V101, P1610, DOI 10.1136/heartjnl-2015-307966
   Lavie CJ, 2015, NAT REV ENDOCRINOL, V11, P55, DOI 10.1038/nrendo.2014.165
   Lavie CJ, 2014, J AM COLL CARDIOL, V63, P1345, DOI 10.1016/j.jacc.2014.01.022
   Lavie CJ, 2013, JACC-HEART FAIL, V1, P93, DOI 10.1016/j.jchf.2013.01.006
   Lavie CJ, 2013, MAYO CLIN PROC, V88, P251, DOI 10.1016/j.mayocp.2012.11.020
   Lavie CJ, 2009, J AM COLL CARDIOL, V53, P1925, DOI 10.1016/j.jacc.2008.12.068
   Lavie CJ, 2003, AM J CARDIOL, V91, P891, DOI 10.1016/S0002-9149(03)00031-6
   Lavie CJ, 2015, PROG CARDIOVASC DIS
   Liu J, 2009, NAT MED, V15, P940, DOI 10.1038/nm.1994
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Maclennan W, 1898, BR MED J BMJ GROUP
   McAuley PA, 2012, MAYO CLIN PROC, V87, P443, DOI 10.1016/j.mayocp.2012.01.013
   MESSERLI FH, 1983, ANN INTERN MED, V99, P757, DOI 10.7326/0003-4819-99-6-757
   MESSERLI FH, 1983, AM J MED, V74, P808, DOI 10.1016/0002-9343(83)91071-9
   Moore LL, 2005, ARCH INTERN MED, V165, P1298, DOI 10.1001/archinte.165.11.1298
   NAKAJIMA T, 1985, CIRCULATION, V71, P481, DOI 10.1161/01.CIR.71.3.481
   Nakamura K, 2014, J CARDIOL, V63, P250, DOI 10.1016/j.jjcc.2013.11.006
   Neeland IJ, 2013, CIRC-CARDIOVASC IMAG, V6, P800, DOI 10.1161/CIRCIMAGING.113.000532
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Odegaard JI, 2011, ANNU REV PATHOL-MECH, V6, P275, DOI 10.1146/annurev-pathol-011110-130138
   Oliver T, 1880, J Anat Physiol, V14, P345
   Ortega FB, 2016, CIRC RES, V118, P1752, DOI 10.1161/CIRCRESAHA.115.306883
   Ortega FB, 2015, PROG CARDIOVASC DIS, V58, P76, DOI 10.1016/j.pcad.2015.05.001
   Park YMM, 2015, J AM COLL CARDIOL, V65, P2091, DOI 10.1016/j.jacc.2015.03.517
   Parto P, 2016, CURR CARDIOVASC RISK, V10, DOI 10.1007/s12170-016-0498-1
   Parto P, 2015, EXPERT REV CARDIOVAS, V13, P1177, DOI 10.1586/14779072.2015.1092384
   Patel Dharmendrakumar A, 2012, Congest Heart Fail, V18, P4, DOI 10.1111/j.1751-7133.2011.00264.x
   Rabah A, 2014, HEART FAIL REV, V19, P325, DOI 10.1007/s10741-013-9411-x
   Sharma A, 2015, AM J CARDIOL, V115, P1428, DOI 10.1016/j.amjcard.2015.02.024
   Shaw KA, 2006, COCH DATAB SYST REV
   Shinbane JS, 1997, J AM COLL CARDIOL, V29, P709, DOI 10.1016/S0735-1097(96)00592-X
   Strissel KJ, 2007, DIABETES, V56, P2910, DOI 10.2337/db07-0767
   Stunkard AJ, 2003, BIOL PSYCHIAT, V54, P330, DOI 10.1016/S0006-3223(03)00608-5
   Talukdar S, 2012, NAT MED, V18, P1407, DOI 10.1038/nm.2885
   Uretsky S, 2013, AM HEART J, V166, P127, DOI 10.1016/j.ahj.2013.03.027
   Wanahita N, 2008, AM HEART J, V155, P310, DOI 10.1016/j.ahj.2007.10.004
   Wang TJ, 2004, JAMA-J AM MED ASSOC, V292, P2471, DOI 10.1001/jama.292.20.2471
   Wang TJ, 2003, CIRCULATION, V107, P2920, DOI 10.1161/01.CIR.0000072767.89944.6E
   Wang ZJ, 2015, HEART, V101, P1631, DOI 10.1136/heartjnl-2014-307119
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Wessel TR, 2004, JAMA-J AM MED ASSOC, V292, P1179, DOI 10.1001/jama.292.10.1179
   Williams CL, 2002, CIRCULATION, V106, P143, DOI 10.1161/01.CIR.0000019555.61092.9E
   Winer DA, 2011, NAT MED, V17, P610, DOI 10.1038/nm.2353
   Winer S, 2009, NAT MED, V15, P921, DOI 10.1038/nm.2001
   Wong CY, 2004, CIRCULATION, V110, P3081, DOI 10.1161/01.CIR.0000147184.13872.0F
   Wu D, 2011, SCIENCE, V332, P243, DOI 10.1126/science.1201475
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
NR 100
TC 41
Z9 45
U1 1
U2 29
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0146-2806
EI 1535-6280
J9 CURR PROB CARDIOLOGY
JI Curr. Probl. Cardiol.
PD NOV
PY 2017
VL 42
IS 11
BP 376
EP 394
DI 10.1016/j.cpcardio1.2017.04.004
PG 19
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FJ5KH
UT WOS:000412789900002
PM 28965561
DA 2025-06-11
ER

PT J
AU Aouira, N
   Khan, S
   Heussler, H
   Haywood, A
   Karaksha, A
   Bor, W
AF Aouira, Nisreen
   Khan, Sohil
   Heussler, Helen
   Haywood, Alison
   Karaksha, Abdullah
   Bor, William
TI Understanding the Perspective of Youths on Undergoing Metabolic
   Monitoring While on Second-Generation Antipsychotics: Challenges,
   Insight, and Implications
SO JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
LA English
DT Article
DE youths; perspective; antipsychotics; barriers; suggestions; health
ID PSYCHOTROPIC MEDICATION; PHYSICAL-ACTIVITY; EXPERIENCE; BARRIERS;
   DEPRESSION; ADOLESCENTS; CHILDREN; CARE; PARTICIPATION; PERCEPTIONS
AB Introduction: Prescription of second-generation antipsychotics (SGAs) in youths is rapidly increasing globally, despite the potential for significant adverse effects and long-term health consequences. A known adverse reaction resulting from SGAs is metabolic syndrome (MS). Youths exposed to antipsychotics are at higher risk than adults for adverse drug reactions, including adverse events such as MS (with weight gain as the most significant adverse outcome) and other long-term endocrinological abnormalities. This study aimed to explore the experiences of young patients on factors impacting barriers to metabolic monitoring of SGAs and the strategies to address those barriers thereby providing further guidance on policy and service delivery.Methods: Semi-structured interviews were conducted with patients (youths who were prescribed SGAs) who attended Child and Youth Mental Health Services. The interviews focused on barriers to monitoring and strategies to enhance rates of monitoring that could be customized across study sites.Results: Young patients revealed that none of them had any concerns or objections to receiving anthropometric metabolic measurements. However, they seemed concerned to undergo blood tests as part of the metabolic monitoring process. Specifically, youths cited their fear of the needles as barrier to undergo the required blood tests. Youths have also reported that their dislike to healthy foods and exercise being the most common challenge they face while trying to engage in a healthy lifestyle to manage the SGAs resulted weight gain.Conclusion: Prescribers are recommended to actively engage young patients about the expected SGAs-induced adverse effects, the importance of conducting metabolic monitoring, and how to prevent and minimize the expected adverse effects from the start of initiating SGAs. This could be a vital step toward a successful treatment as the insight of youths into the details of the chosen treatment can play a significant role into treatment adherence and recovery.
C1 [Aouira, Nisreen; Khan, Sohil; Haywood, Alison; Karaksha, Abdullah] Griffith Univ, Menzies Hlth Inst Queensland, Sch Pharm & Med Sci, Gold Coast, Australia.
   [Khan, Sohil; Heussler, Helen; Haywood, Alison; Bor, William] Univ Queensland, Mater Res Inst, Brisbane, Australia.
   [Khan, Sohil] Prasanna Inst Publ Hlth, Manipal, India.
   [Khan, Sohil] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Manipal, India.
   [Heussler, Helen; Bor, William] Childrens Hlth Queensland Hosp & Hlth Serv, Brisbane, Australia.
   [Bor, William] Queensland Hlth, Ctr Childrens Hlth Res, Child & Youth Mental Hlth Serv, Brisbane, Australia.
   [Aouira, Nisreen] Griffith Univ, Menzies Hlth Inst Queensland, Sch Pharm & Med Sci, Gold Coast 4222, Australia.
C3 Menzies Health Institute Queensland; Griffith University; Griffith
   University - Gold Coast Campus; University of Queensland; Mater
   Research; Manipal Academy of Higher Education (MAHE); Childrens Health
   Queensland Hospital & Health Service; Queensland Health; Menzies Health
   Institute Queensland; Griffith University; Griffith University - Gold
   Coast Campus
RP Aouira, N (corresponding author), Griffith Univ, Menzies Hlth Inst Queensland, Sch Pharm & Med Sci, Gold Coast 4222, Australia.
EM n.aouira@griffith.edu.au
RI Bor, William/J-2215-2015
OI Haywood, Alison/0000-0002-5354-8868; Aouira, Nisreen/0000-0001-9297-6737
CR Arora N, 2016, CAN J PSYCHIAT, V61, P758, DOI 10.1177/0706743716649190
   Bradley KL, 2010, COMMUNITY MENT HLT J, V46, P242, DOI 10.1007/s10597-009-9224-5
   Braun Virginia., 2019, HDB RES METHODS HLTH
   Bülow P, 2016, ISSUES MENT HEALTH N, V37, P820, DOI 10.1080/01612840.2016.1224283
   Caporino NE, 2012, J ADOLESCENCE, V35, P1237, DOI 10.1016/j.adolescence.2012.04.007
   Carlsen B, 2011, BMC MED RES METHODOL, V11, DOI 10.1186/1471-2288-11-26
   Cegala DJ, 2007, HEALTH COMMUN, V21, P177, DOI 10.1080/10410230701307824
   Chernomas Wanda M, 2017, JBI Database System Rev Implement Rep, V15, P694, DOI 10.11124/JBISRIR-2016-002942
   Choudhury S, 2015, SOC SCI MED, V143, P311, DOI 10.1016/j.socscimed.2015.02.034
   Chovil N, 2010, J CAN ACAD CHILD ADO, V19, P201
   Connolly JG, 2015, PSYCHIAT SERV, V66, P604, DOI 10.1176/appi.ps.201400222
   Coughlin M, 2018, INT J MENT HEALTH NU, V27, P1188, DOI 10.1111/inm.12417
   Coughlin M, 2018, CAN J PSYCHIAT, V63, P240, DOI 10.1177/0706743717751693
   Cree L, 2015, BMC PSYCHIATRY, V15, DOI 10.1186/s12888-015-0590-y
   Delman J, 2015, J BEHAV HEALTH SER R, V42, P238, DOI 10.1007/s11414-014-9431-x
   Edlund MJ, 2015, PSYCHIAT SERV, V66, P1064, DOI 10.1176/appi.ps.201400018
   Floersch Jerry, 2004, Soc Work Ment Health, V1, P51, DOI 10.1300/J200v01n04_04
   Floersch J, 2009, TRANSCULT PSYCHIATRY, V46, P157, DOI 10.1177/1363461509102292
   Foltz R, 2014, J CHILD FAM STUD, V23, P752, DOI 10.1007/s10826-013-9842-y
   Gnanavel S, 2018, WORLD J PSYCHIATR, V8, P27, DOI 10.5498/wjp.v8.i1.27
   Guest G, 2006, FIELD METHOD, V18, P59, DOI 10.1177/1525822X05279903
   Gulliver A, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-81
   Gulliver A, 2010, BMC PSYCHIATRY, V10, DOI 10.1186/1471-244X-10-113
   Hamrin V, 2010, J CHILD ADOL PS NURS, V23, P151, DOI 10.1111/j.1744-6171.2010.00237.x
   Hayden JD, 2020, J CHILD ADOL PSYCHOP, V30, P119, DOI 10.1089/cap.2019.0087
   Johnstone R, 2009, J MENT HEALTH, V18, P523, DOI 10.3109/09638230903111114
   Kaushik A, 2016, PSYCHIAT RES, V243, P469, DOI 10.1016/j.psychres.2016.04.042
   Khan AY, 2010, J PAK MED ASSOC, V60, P446
   Kisely S, 2011, AUSTRALAS PSYCHIATRY, V19, P364, DOI 10.3109/10398562.2011.562508
   Lin P, 2005, ANN BEHAV MED, V30, P164, DOI 10.1207/s15324796abm3002_9
   Longhofer Jeffrey, 2010, Anthropol Med, V17, P159, DOI 10.1080/13648470.2010.493599
   McDevitt J, 2006, J NURS SCHOLARSHIP, V38, P50, DOI 10.1111/j.1547-5069.2006.00077.x
   McLenon J, 2019, J ADV NURS, V75, P30, DOI 10.1111/jan.13818
   McMillan SS, 2022, J MENT HEALTH, V31, P281, DOI 10.1080/09638237.2020.1714000
   Morant Nicola, 2018, J Ment Health, V27, P322, DOI 10.1080/09638237.2017.1370637
   Morrison P, 2015, INT J MENT HEALTH NU, V24, P253, DOI 10.1111/inm.12110
   Nicol G, 2016, CHILD OBES, V12, P70, DOI 10.1089/chi.2015.0076
   Nwankwo L, 2021, BMJ OPEN QUAL, V10, DOI 10.1136/bmjoq-2020-001192
   O'Brien M, 2013, COMMUNITY MENT HLT J, V49, P567, DOI 10.1007/s10597-012-9526-x
   Rice Jessie, 2020, Med Sci (Basel), V8, DOI 10.3390/medsci8030034
   Roberts SH, 2013, J ADV NURS, V69, P2514, DOI 10.1111/jan.12136
   Schofield P, 2011, BRIT J GEN PRACT, V61, DOI 10.3399/bjgp11X567045
   Steinberg L, 2001, ANNU REV PSYCHOL, V52, P83, DOI 10.1146/annurev.psych.52.1.83
   TenHave TR, 2003, GEN HOSP PSYCHIAT, V25, P115, DOI 10.1016/S0163-8343(02)00275-X
   Townsend L., 2010, CHILD ADOLESCENT PSY, V15, P7
   Vasileiou K, 2018, BMC MED RES METHODOL, V18, DOI 10.1186/s12874-018-0594-7
   Wolraich ML, 2003, J PEDIATR PSYCHOL, V28, P559, DOI 10.1093/jpepsy/jsg046
   Woodgate Roberta L, 2017, JBI Database System Rev Implement Rep, V15, P276, DOI 10.11124/JBISRIR-2016003283
   Xu Y, 2012, J CAN ACAD CHILD ADO, V21, P302
NR 49
TC 1
Z9 1
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1044-5463
EI 1557-8992
J9 J CHILD ADOL PSYCHOP
JI J. Child Adolesc. Psychopharmacol.
PD SEP 1
PY 2023
VL 33
IS 7
BP 279
EP 286
DI 10.1089/cap.2023.0016
EA JUL 2023
PG 8
WC Pediatrics; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Pharmacology & Pharmacy; Psychiatry
GA S3GE8
UT WOS:001037832600001
PM 37504897
DA 2025-06-11
ER

PT J
AU Tarar, BI
   Knox, A
   Dean, CA
   Brown, EC
AF Tarar, Bilal Ihsan
   Knox, Allan
   Dean, Caress Alithia
   Brown, Elise Catherine
TI Resistance training responses across race and ethnicity: a narrative
   review
SO ETHNICITY & HEALTH
LA English
DT Review
DE Resistance exercise; cardiometabolic risk factors; muscle strength;
   vascular endothelial growth factors; cholesterol; LDL; HDL; blood
   pressure; vascular stiffness; body mass index; waist circumference;
   insulin resistance; glucose; inflammation; c-reactive protein
ID YOUNG AFRICAN-AMERICAN; C-REACTIVE PROTEIN; RACIAL-DIFFERENCES; DIABETES
   MORTALITY; ENERGY-EXPENDITURE; OXIDATIVE STRESS; WEIGHT-LOSS; EXERCISE;
   MASS; STRENGTH
AB ObjectivesAlthough the physiological mechanisms are not fully understood, race/ethnicity differences vary across cardiometabolic disease risk factors. Resistance training (RT) is an effective therapy for improving these risk factors in addition to body composition and physical performance. Thus, the purpose of this study was to determine the effects of RT over time on different racial and ethnic populations across cardiometabolic, body composition, and physical performance outcomes.DesignElectronic databases Scopus and PubMed were searched for studies that compared different racial/ethnic responses to RT across cardiometabolic, body composition, and physical performance parameters. Inclusion criteria for the studies were as follows: (1) published in the English language; (2) compared races or ethnicities across cardiometabolic risk factors, body composition, or physical performance variables following a RT intervention; (3) included adults 18 years or older, and (4) included an isolated RT intervention group.ResultsNine studies were found that met the inclusion criteria. The identified studies involved cohorts of White American (WA), South Asian, European Chilean, Mapuche Chilean, White Scottish, and African American (AA) males and females. Race/ethnicity differences following a RT intervention were found for fat-free mass preservation and changes in blood pressure, endothelial function, brachial artery stiffness, cardiac autonomic function, inflammatory and oxidative stress markers, insulin sensitivity, body mass index, waist circumference, % body fat, and muscular strength. With the exception of changes in systolic blood pressure and brachial artery stiffness, AAs consistently showed more beneficial adaptations compared to WAs to RT across studies.ConclusionRace and ethnicity play a role in how adults adapt to chronic RT. These data may aid in better understanding the social, biological, and environmental factors that likely influenced these racial/ethnic differences in response to RT, assist in creating tailored exercise prescriptions for various racial/ethnic populations, and inform policies for determining resource allocations to address health inequities.
C1 [Tarar, Bilal Ihsan] Oakland Univ, Sch Hlth Sci, Dept Interdisciplinary Hlth Sci, Rochester, MI USA.
   [Knox, Allan] Calif Lutheran Univ, Coll Arts & Sci, Dept Exercise Sci, Thousand Oaks, CA USA.
   [Dean, Caress Alithia; Brown, Elise Catherine] Oakland Univ, Sch Hlth Sci, Dept Publ & Environm Wellness, Rochester, MI USA.
   [Brown, Elise Catherine] Oakland Univ, Sch Hlth Sci, Dept Publ & Environm Wellness, 433 Meadow Brook Rd, Rochester, MI 48309 USA.
   [Tarar, Bilal Ihsan] Oakland Univ, William Beaumont Sch Med, Rochester, MI USA.
C3 Oakland University; California Lutheran University; Oakland University;
   Oakland University; Oakland University
RP Brown, EC (corresponding author), Oakland Univ, Sch Hlth Sci, Dept Publ & Environm Wellness, 433 Meadow Brook Rd, Rochester, MI 48309 USA.
EM elisebrown@oakland.edu
CR Alvarez C, 2019, SCAND J MED SCI SPOR, V29, P886, DOI 10.1111/sms.13409
   Anand SS, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0022112
   Araujo AB, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-508
   Ashton RE, 2020, BRIT J SPORT MED, V54, P341, DOI 10.1136/bjsports-2017-098970
   Brothers RM, 2019, AM J PHYSIOL-HEART C, V317, pH777, DOI 10.1152/ajpheart.00126.2019
   Brown EC, 2020, J DIABETES COMPLICAT, V34, DOI 10.1016/j.jdiacomp.2020.107610
   Brown EC, 2020, AM J PREV MED, V58, P757, DOI 10.1016/j.amepre.2020.01.016
   CALHOUN DA, 1993, HYPERTENSION, V22, P801, DOI 10.1161/01.HYP.22.6.801
   Chen LQ, 2011, ATHEROSCLEROSIS, V219, P833, DOI 10.1016/j.atherosclerosis.2011.08.029
   Cheng YLJ, 2019, JAMA-J AM MED ASSOC, V322, P2389, DOI 10.1001/jama.2019.19365
   Cook MD, 2013, J HUM HYPERTENS, V27, P388, DOI 10.1038/jhh.2012.48
   Cormie P, 2011, SPORTS MED, V41, P17, DOI 10.2165/11537690-000000000-00000
   Donges CE, 2010, MED SCI SPORT EXER, V42, P304, DOI 10.1249/MSS.0b013e3181b117ca
   Drew RC, 2020, AM J PHYSIOL-REG I, V318, pR234, DOI 10.1152/ajpregu.00091.2019
   Gallagher D, 1997, J APPL PHYSIOL, V83, P229, DOI 10.1152/jappl.1997.83.1.229
   Graham JE, 2008, J GERONTOL A-BIOL, V63, P860, DOI 10.1093/gerona/63.8.860
   Hackler E III, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.119.012729
   Heffernan KS, 2009, ATHEROSCLEROSIS, V207, P220, DOI 10.1016/j.atherosclerosis.2009.03.043
   Heffernan KS, 2009, AM J PHYSIOL-REG I, V296, pR1098, DOI 10.1152/ajpregu.90936.2008
   Hunt BR, 2014, DIABETES CARE, V37, P1279, DOI 10.2337/dc13-0988
   Hunter GR, 2008, OBESITY, V16, P1045, DOI 10.1038/oby.2008.38
   Hunter GR, 2018, OBESITY, V26, P1255, DOI 10.1002/oby.22201
   Kaplan JB, 2003, JAMA-J AM MED ASSOC, V289, P2709, DOI 10.1001/jama.289.20.2709
   Kimm SYS, 2002, AM J CLIN NUTR, V75, P714, DOI 10.1093/ajcn/75.4.714
   Knox A., 2018, F1000RESEARCH, V7, P1334, DOI [10.12688/f1000research.15376.1, DOI 10.12688/F1000RESEARCH.15376.2, DOI 10.12688/F1000RESEARCH.15376.1]
   Knox A, 2017, RES SPORTS MED, V25, P373, DOI 10.1080/15438627.2017.1314293
   Leong DP, 2015, LANCET, V386, P266, DOI 10.1016/S0140-6736(14)62000-6
   Mancilla VJ, 2020, FRONT GENET, V11, DOI 10.3389/fgene.2020.00903
   MAYET J, 1994, BMJ-BRIT MED J, V308, P1011, DOI 10.1136/bmj.308.6935.1011
   Phillips SM, 2010, CURR SPORT MED REP, V9, P208, DOI 10.1249/JSR.0b013e3181e7da73
   Qadir R, 2021, SPORTS MED-OPEN, V7, DOI 10.1186/s40798-021-00321-x
   Ranadive SM, 2016, MED SCI SPORT EXER, V48, P90, DOI 10.1249/MSS.0000000000000742
   Raven PB, 2006, EXP PHYSIOL, V91, P37, DOI 10.1113/expphysiol.2005.032250
   Raygor V, 2019, DIABETES VASC DIS RE, V16, P153, DOI 10.1177/1479164118813890
   Ribeiro AS, 2015, AGE, V37, DOI 10.1007/s11357-015-9849-y
   Roberts CK, 2006, J APPL PHYSIOL, V100, P1657, DOI 10.1152/japplphysiol.01292.2005
   Roig M, 2009, BRIT J SPORT MED, V43, P556, DOI 10.1136/bjsm.2008.051417
   Rosenstock S, 2014, J URBAN HEALTH, V91, P873, DOI 10.1007/s11524-013-9861-4
   Schroeder EC, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0210292
   Shah AD, 2016, INT J OBESITY, V40, P639, DOI 10.1038/ijo.2015.219
   Stoever K, 2018, J GERIATR PHYS THER, V41, P20, DOI 10.1519/JPT.0000000000000105
   Stull AJ, 2010, METABOLISM, V59, P1358, DOI 10.1016/j.metabol.2009.12.020
   Sukala WR, 2012, DIABETES RES CLIN PR, V97, P206, DOI 10.1016/j.diabres.2012.02.001
   Thorpe RJ, 2017, BIODEMOGR SOC BIOL, V63, P253, DOI 10.1080/19485565.2017.1353406
   Treiber FA, 2000, HYPERTENSION, V35, P722, DOI 10.1161/01.HYP.35.3.722
   Wagner DR, 2000, AM J CLIN NUTR, V71, P1392
   Weinsier RL, 2000, AM J CLIN NUTR, V71, P1138
   Willis LH, 2012, J APPL PHYSIOL, V113, P1831, DOI 10.1152/japplphysiol.01370.2011
   Winnick JJ, 2008, ETHNIC DIS, V18, P152
   Wolf ST, 2020, AM J PHYSIOL-HEART C, V319, pH1409, DOI 10.1152/ajpheart.00698.2020
NR 50
TC 1
Z9 1
U1 0
U2 2
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1355-7858
EI 1465-3419
J9 ETHNIC HEALTH
JI Ethn. Health
PD NOV 17
PY 2023
VL 28
IS 8
BP 1221
EP 1237
DI 10.1080/13557858.2023.2212147
EA MAY 2023
PG 17
WC Ethnic Studies; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Ethnic Studies; Public, Environmental & Occupational Health
GA X7CT8
UT WOS:000987109500001
PM 37183720
DA 2025-06-11
ER

PT J
AU Amara-Leffad, LO
   Ramdane, H
   Nekhoul, K
   Ouznadji, A
   Koceir, EA
AF Amara-Leffad, Lydia Ould
   Ramdane, Houria
   Nekhoul, Khaoula
   Ouznadji, Amira
   Koceir, Elhadj Ahmed
TI Spirulina effect on modulation of toxins provided by food, impact
   on hepatic and renal functions
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Oxidative stress; inflammatory status; hepatic steatosis; renal
   insufficiency; oxidised oil; Spirulina; metabolic syndrome
ID FATTY LIVER-DISEASE; OXIDATIVE STRESS; FUSIFORMIS; KIDNEY
AB Spirulina platensis, is an alga rich in phycocyanin (potent antioxidant), is effective in regulating the balance of oxidative stress. The objective of this study is to observe the impact of ingestion of a highly oxidised vegetable oil, by rats of Wistar strain. Finally, we observe the effect of Spirulina used as an antioxidant treatment, on rats having ingested a diet rich in highly oxidised oil. Physiological, biochemical and histological studies have been carried out; the oxidative stress parameters evaluated and a dosing of Cytochrome P450 2E1 was finally carried out. Following the introduction of highly oxidised vegetable oil, rats showed deterioration in their metabolic state, an imbalance in the balance of oxidative stress, an increase in serum concentrations of Cytochrome P450 2E1 and significant hepatic lesions. The administration of a daily dose of Spirulina reduces the deleterious effect of oxidative stress induced by a diet enriched with lipid peroxides.
C1 [Amara-Leffad, Lydia Ould; Ramdane, Houria; Koceir, Elhadj Ahmed] USTHB, Bioenerget & Intermediary Metab Lab, Dept Biol Sci & Physiol, Algiers, Algeria.
   [Nekhoul, Khaoula] Algiers Univ 1, Lab Pharmacol, Algiers, Algeria.
   [Ouznadji, Amira] Algiers Univ 1, Lab Biochem, Algiers, Algeria.
C3 University Science & Technology Houari Boumediene
RP Amara-Leffad, LO (corresponding author), USTHB, Bioenerget & Metab Intermediaire, LBPO, FSB, Algiers, Algeria.
EM ouldamaralydia@gmail.com
OI KOCEIR, Elhadj-Ahmed/0000-0003-1345-2535
CR Adedara IA, 2012, ENVIRON TOXICOL, V27, P372, DOI 10.1002/tox.20660
   Angulo P, 2002, NEW ENGL J MED, V346, P1221, DOI 10.1038/nrdp.2015.80
   [Anonymous], THESIS
   [Anonymous], CLIN NUTR METAB, DOI [10.1016/S0985-0562(02)00166-8, DOI 10.1016/S0985-0562(02)00166-8]
   [Anonymous], THESIS U NANCY 1
   [Anonymous], 2017, PHYTOTHERAPIE, DOI [DOI 10.1007/S10298-017-1099-Y, 10.1007/s10298-017- 1099-y]
   [Anonymous], MED THERAPEUTIQUE CA
   [Anonymous], HEPATO GASTRO ONCOLO
   [Anonymous], THESIS U LIBRE BRUXE
   [Anonymous], LARHYSS J
   [Anonymous], HEPATO GASTRO ONCOLO
   [Anonymous], VALORISATION PELURES
   [Anonymous], THESIS I NATL POLYTE
   [Anonymous], OBESITE
   [Anonymous], IMMUNO ANAL BIOL SPE
   [Anonymous], THESIS ECOLE NATL SU
   [Anonymous], CURRENT TRENNDS BIOT
   Atli G, 2006, COMP BIOCHEM PHYS C, V143, P218, DOI 10.1016/j.cbpc.2006.02.003
   Aubert J, 2011, CLIN RES HEPATOL GAS, V35, P630, DOI 10.1016/j.clinre.2011.04.015
   Barry M., 2014, International Journal of Biological and Chemical Sciences, V8, P2740
   Baumelou A, 2005, AM J NEPHROL, V25, P95, DOI 10.1159/000084660
   Brown SA, 2008, VET CLIN N AM-SMALL, V38, P157, DOI 10.1016/j.cvsm.2007.11.001
   Codoñer-Franch P, 2011, ATHEROSCLEROSIS, V215, P475, DOI 10.1016/j.atherosclerosis.2010.12.035
   Compagnucci CV, 2002, NEUROIMMUNOMODULAT, V10, P153, DOI 10.1159/000067177
   Dal-Ros S., 2014, Diabetes Metab, V40, pA83, DOI [10.1016/S1262-3636(14)72525-X, DOI 10.1016/S1262-3636(14)72525-X]
   Defraigne J O, 2005, Rev Med Liege, V60, P472
   Donath MY, 2011, NAT REV IMMUNOL, V11, P98, DOI 10.1038/nri2925
   Estrada JEP, 2001, FARMACO, V56, P497
   Farag AGA, 2010, PESTIC BIOCHEM PHYS, V97, P267, DOI 10.1016/j.pestbp.2010.03.007
   Farnier M, 2010, DIABETES METAB, V36, pA93, DOI 10.1016/S1262-3636(10)70381-5
   Förstermann U, 2012, EUR HEART J, V33, P829, DOI 10.1093/eurheartj/ehr304
   Fromenty B, 2014, NUTR CLIN METAB, V28, P95, DOI 10.1016/j.nupar.2013.10.001
   Guibourdenche J, 2013, ANN BIOL CLIN-PARIS, V71, P79, DOI 10.1684/abc.2013.0903
   Haleng J, 2007, Rev Med Liege, V62, P628
   Jeyaprakash K., 2007, Journal of Natural Remedies, V7, P80
   Karadeniz A, 2008, PHYTOTHER RES, V22, P1506, DOI 10.1002/ptr.2522
   Krauss RM, 2004, MED CLIN N AM, V88, P897, DOI 10.1016/j.mcna.2004.04.004
   Kumar M, 2005, J HEALTH SCI, V51, P424, DOI 10.1248/jhs.51.424
   Martin SJ, 2014, TOXICOL MECH METHOD, V24, P584, DOI 10.3109/15376516.2014.956910
   Messaadia A., 2013, African Journal of Biotechnology, V12, P5909
   Moor V.J.A., 2017, BMC NUTR, V3, P25, DOI DOI 10.1186/s40795-017-0146-2
   Nève J, 2002, CURR OPIN CLIN NUTR, V5, P659, DOI 10.1097/00075197-200211000-00008
   Payen JL, 2011, PRESSE MED, V40, P567, DOI 10.1016/j.lpm.2011.01.024
   Pessayre D, 2002, AM J PHYSIOL-GASTR L, V282, pG193, DOI 10.1152/ajpgi.00426.2001
   Ponce-Canchihuamán JC, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-35
   Rahman M.A., 2012, J. Environ. Sci. Nat. Resour, V5, P79
   Rubbia-Brandt Laura, 2005, Rev Med Suisse, V1, P2804
   Salem ML, 2005, INT IMMUNOPHARMACOL, V5, P1749, DOI 10.1016/j.intimp.2005.06.008
   Samuels R., 2002, Journal of Medicinal Food, V5, P91
   Singh S, 2011, CANCER CHEMOTH PHARM, V67, P1211, DOI 10.1007/s00280-011-1654-4
   Thirumala M., 2012, International Journal of Life Sciences Biotechnology and Pharma Research, V1, P152
   Upasani CD, 2003, PHYTOTHER RES, V17, P330, DOI 10.1002/ptr.1135
   Zafrani ES, 2004, VIRCHOWS ARCH, V444, P3, DOI 10.1007/s00428-003-0943-7
NR 53
TC 6
Z9 6
U1 0
U2 10
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD MAR 15
PY 2019
VL 125
IS 2
BP 184
EP 194
DI 10.1080/13813455.2018.1444059
PG 11
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA HQ4FY
UT WOS:000462366900012
PM 29484960
DA 2025-06-11
ER

PT J
AU Liu, YQ
   Fan, Y
   Liu, JB
   Liu, XY
   Li, XY
   Hu, JQ
AF Liu, Yuqiao
   Fan, Yue
   Liu, Jibin
   Liu, Xiyang
   Li, Xiuyan
   Hu, Jingqing
TI Application and mechanism of Chinese herb medicine in the treatment of
   non-alcoholic fatty liver disease
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE non-alcoholic fatty liver disease (NAFLD); Chinese herb medicine (CHM);
   insulin resistance; lipid metabolism disorder; mitochondrial
   dysfunction; oxidative stress; endoplasmic reticulum stress
ID ENDOPLASMIC-RETICULUM STRESS; DE-NOVO LIPOGENESIS; HEPATIC STEATOSIS;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; VITAMIN-E; MITOCHONDRIAL
   DYSFUNCTION; SIGNALING PATHWAY; TANSHINONE IIA; X-RECEPTOR
AB Non-alcoholic fatty liver disease (NAFLD) is a chronic liver condition closely associated with metabolic syndrome, with its incidence rate continuously rising globally. Recent studies have shown that the development of NAFLD is associated with insulin resistance, lipid metabolism disorder, oxidative stress and endoplasmic reticulum stress. Therapeutic strategies for NAFLD include lifestyle modifications, pharmacological treatments, and emerging biological therapies; however, there is currently no specific drug to treat NAFLD. However Chinese herb medicine (CHM) has shown potential in the treatment of NAFLD due to its unique therapeutic concepts and methods for centuries in China. This review aims to summarize the pathogenesis of NAFLD and some CHMs that have been shown to have therapeutic effects on NAFLD, thus enriching the scientific connotation of TCM theories and facilitating the exploration of TCM in the treatment of NAFLD.
C1 [Liu, Yuqiao; Fan, Yue; Liu, Jibin; Liu, Xiyang; Li, Xiuyan; Hu, Jingqing] Chengdu Univ Tradit Chinese Med, Coll Basic Med Sci, Chengdu, Peoples R China.
   [Hu, Jingqing] Xin Huangpu Joint Innovat Inst Chinese Med, Guangzhou, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine
RP Hu, JQ (corresponding author), Chengdu Univ Tradit Chinese Med, Coll Basic Med Sci, Chengdu, Peoples R China.; Hu, JQ (corresponding author), Xin Huangpu Joint Innovat Inst Chinese Med, Guangzhou, Peoples R China.
EM gcp306@126.com
RI Liu, Jibin/NGC-2812-2025
FU National Natural Science Foundation of China [82074316]; Sichuan Science
   and Technology Program [2024NSFSC1829]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This study was
   funded by the National Natural Science Foundation of China (No.
   82074316) and Sichuan Science and Technology Program (No.
   2024NSFSC1829).
CR Abenavoli L, 2010, PHYTOTHER RES, V24, P1423, DOI 10.1002/ptr.3207
   Ajoolabady A, 2023, HEPATOLOGY, V77, P619, DOI 10.1002/hep.32562
   Anwar SD, 2023, ENDOCRIN METAB CLIN, V52, P445, DOI 10.1016/j.ecl.2023.01.003
   Bahorun T, 2003, NAHRUNG, V47, P191, DOI 10.1002/food.200390045
   Barros L, 2011, PHYTOCHEM ANALYSIS, V22, P181, DOI 10.1002/pca.1267
   Begriche K, 2006, MITOCHONDRION, V6, P1, DOI 10.1016/j.mito.2005.10.004
   Begriche K, 2013, HEPATOLOGY, V58, P1497, DOI 10.1002/hep.26226
   Branch of Gastrointestinal Diseases China Association of Chinese Medicine, 2017, CHIN J CLIN HEPATOL, V33, P2270, DOI [DOI 10.3969/J.ISSN.1001-5256.2017.12.002, 10.3969/j.issn.1001-5256.2017.12.002]
   Buzzetti E, 2016, METABOLISM, V65, P1038, DOI 10.1016/j.metabol.2015.12.012
   Cao L, 2022, CHIN MED-UK, V17, DOI 10.1186/s13020-021-00559-3
   [操颖 Cao Ying], 2024, [中华中医药杂志, China Journal of Traditional Chinese Medicine and Pharmacy], V39, P2195
   Cao Y, 2022, BIOMED PHARMACOTHER, V149, DOI 10.1016/j.biopha.2022.112825
   Cao YH, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.858795
   Cen B.C., 2013, Chin. Arch. Trad. Chin. Med, V31, P545, DOI [10.13193/j.archtcm.2013.03.99.cenbch.054, DOI 10.13193/J.ARCHTCM.2013.03.99.CENBCH.054]
   Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI 10.1002/hep.29367
   Chang GR, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222111383
   Chen DL, 2024, FRONT PHARMACOL, V15, DOI 10.3389/fphar.2024.1343755
   Chen YY, 2023, J ETHNOPHARMACOL, V306, DOI 10.1016/j.jep.2023.116199
   Chen Z, 2020, FREE RADICAL BIO MED, V152, P116, DOI 10.1016/j.freeradbiomed.2020.02.025
   Ciardullo S, 2021, METABOLISM, V121, DOI 10.1016/j.metabol.2021.154752
   Cui CX, 2017, J ETHNOPHARMACOL, V208, P24, DOI 10.1016/j.jep.2017.06.030
   Cusi K, 2016, ANN INTERN MED, V165, P305, DOI 10.7326/M15-1774
   Dai L, 2022, FRONT MED-PRC, V16, P745, DOI 10.1007/s11684-021-0880-3
   Dai XM, 2021, CHIN MED-UK, V16, DOI 10.1186/s13020-021-00469-4
   Dang YQ, 2020, BIOMED PHARMACOTHER, V127, DOI 10.1016/j.biopha.2020.109976
   Degli Esposti Davide, 2012, Biochem Res Int, V2012, P387626, DOI 10.1155/2012/387626
   Denechaud PD, 2008, FEBS LETT, V582, P68, DOI 10.1016/j.febslet.2007.07.084
   Deng YJ, 2019, MOLECULES, V24, DOI 10.3390/molecules24213943
   Dentin R, 2006, DIABETES, V55, P2159, DOI 10.2337/db06-0200
   Diehl AM, 2017, NEW ENGL J MED, V377, P2063, DOI 10.1056/NEJMra1503519
   Ding CC, 2016, SCI REP-UK, V6, DOI 10.1038/srep28734
   Ding MN, 2023, CHIN HERB MED, V15, P421, DOI 10.1016/j.chmed.2022.09.006
   Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI23621
   Eberlé D, 2004, BIOCHIMIE, V86, P839, DOI 10.1016/j.biochi.2004.09.018
   Eckstein SS, 2017, CURR MED CHEM, V24, P1827, DOI 10.2174/0929867324666170426142826
   Ekhlasi G, 2016, J RES MED SCI, V21, DOI 10.4103/1735-1995.193178
   El-Agroudy NN, 2019, TRENDS ENDOCRIN MET, V30, P701, DOI 10.1016/j.tem.2019.07.013
   Fan CL, 2023, CHIN J NAT MEDICINES, V21, P411, DOI 10.1016/S1875-5364(23)60403-0
   Fan JG, 2013, J GASTROEN HEPATOL, V28, P81, DOI 10.1111/jgh.12244
   Fang YL, 2018, WORLD J GASTROENTERO, V24, P2974, DOI 10.3748/wjg.v24.i27.2974
   Ferré P, 2010, DIABETES OBES METAB, V12, P83, DOI 10.1111/j.1463-1326.2010.01275.x
   Flamment M, 2010, CURR OPIN LIPIDOL, V21, P239, DOI 10.1097/MOL.0b013e3283395e5c
   Forrester SJ, 2018, CIRC RES, V122, P877, DOI 10.1161/CIRCRESAHA.117.311401
   Friedman SL, 2018, NAT MED, V24, P908, DOI 10.1038/s41591-018-0104-9
   Fujii H, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21113863
   Gao G, 2024, PHYTOMEDICINE, V128, DOI 10.1016/j.phymed.2023.155313
   Gentile CL, 2011, ANTIOXID REDOX SIGN, V15, P505, DOI 10.1089/ars.2010.3790
   Glimcher LH, 2009, ANN NY ACAD SCI, V1173, pE2, DOI 10.1111/j.1749-6632.2009.04956.x
   Golabi P, 2016, WORLD J GASTROENTERO, V22, P6318, DOI 10.3748/wjg.v22.i27.6318
   Gong J, 2017, J ZHEJIANG UNIV-SC B, V18, P1, DOI 10.1631/jzus.B1600043
   Gong M., 2017, China Pharm, V28, P4776, DOI [10.6039/j.issn.1001-0408.2017.34.06, DOI 10.6039/J.ISSN.1001-0408.2017.34.06]
   Gu YQ, 2022, PHYTOMEDICINE, V103, DOI 10.1016/j.phymed.2022.154219
   [郭思敏 Guo Simin], 2023, [中国药学杂志, Chinese Pharmaceutical Journal], V58, P584
   Han RT, 2021, PHYTOMEDICINE, V85, DOI 10.1016/j.phymed.2021.153544
   He D, 2016, J CARDIOVASC PHARM, V67, P510, DOI 10.1097/FJC.0000000000000373
   Heeren J, 2021, MOL METAB, V50, DOI 10.1016/j.molmet.2021.101238
   Higuchi N, 2008, HEPATOL RES, V38, P1122, DOI 10.1111/j.1872-034X.2008.00382.x
   Ho CK, 2019, J CELL MOL MED, V23, P5108, DOI 10.1111/jcmm.14380
   Hong M, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18030620
   Hong W, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.529553
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   Iizuka K, 2004, P NATL ACAD SCI USA, V101, P7281, DOI 10.1073/pnas.0401516101
   Iizuka K, 2008, ENDOCR J, V55, P617, DOI 10.1507/endocrj.K07E-110
   Ipsen DH, 2018, CELL MOL LIFE SCI, V75, P3313, DOI 10.1007/s00018-018-2860-6
   Jacome-Sosa MM, 2014, CURR OPIN LIPIDOL, V25, P213, DOI 10.1097/MOL.0000000000000080
   James OFW, 1998, J HEPATOL, V29, P495, DOI 10.1016/S0168-8278(98)80073-1
   Jia LQ, 2016, MOL MED REP, V13, P4627, DOI 10.3892/mmr.2016.5133
   Jia WY, 2022, PHYTOMEDICINE, V104, DOI 10.1016/j.phymed.2022.154326
   Jiang H, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.908128
   Jiang WN, 2018, CHIN J INTEGR MED, V24, P125, DOI 10.1007/s11655-016-2252-4
   Karkucinska-Wieckowska A, 2022, EUR J CLIN INVEST, V52, DOI 10.1111/eci.13622
   Kaufman RJ, 1999, GENE DEV, V13, P1211, DOI 10.1101/gad.13.10.1211
   Khan RS, 2019, HEPATOLOGY, V70, P711, DOI 10.1002/hep.30429
   Kim I, 2008, NAT REV DRUG DISCOV, V7, P1013, DOI 10.1038/nrd2755
   Kim MS, 2016, J CLIN INVEST, V126, P4372, DOI 10.1172/JCI81993
   Kirakosyan A, 2003, J AGR FOOD CHEM, V51, P3973, DOI 10.1021/jf030096r
   Kohjima M, 2007, INT J MOL MED, V20, P351
   Kumashiro N, 2011, P NATL ACAD SCI USA, V108, P16381, DOI 10.1073/pnas.1113359108
   Lan QP, 2021, CHIN MED-UK, V16, DOI 10.1186/s13020-021-00434-1
   Lan T, 2021, HEPATOLOGY, V74, P686, DOI 10.1002/hep.31749
   Law BYK, 2014, CHIN MED-UK, V9, DOI 10.1186/1749-8546-9-21
   Lei SS, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.967623
   Leng J, 2020, PHYTOMEDICINE, V66, DOI 10.1016/j.phymed.2019.153135
   Li CJ, 2020, EUR J PHARMACOL, V882, DOI 10.1016/j.ejphar.2020.173264
   Li CL, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.833414
   Li Q, 2012, FITOTERAPIA, V83, P1046, DOI 10.1016/j.fitote.2012.05.009
   Li ST, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.560905
   Li W, 2020, APPL MICROBIOL BIOT, V104, P6129, DOI 10.1007/s00253-020-10614-y
   Li XJY, 2018, PHYTOMEDICINE, V50, P73, DOI 10.1016/j.phymed.2018.09.174
   Li XL, 2022, J TRADIT CHIN MED, V42, P940, DOI 10.19852/j.cnki.jtcm.2022.06.007
   Lin X. P., 2021, Chin. J. Clin. Med, V28, P106, DOI [10.12025/j.issn.1008-6358.2021.20200155, DOI 10.12025/J.ISSN.1008-6358.2021.20200155]
   Liu WW, 2022, J ETHNOPHARMACOL, V295, DOI 10.1016/j.jep.2022.115382
   Liu YY, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.875700
   Lu HF, 2020, J GINSENG RES, V44, P238, DOI 10.1016/j.jgr.2018.10.005
   Luo DS, 2022, FRONT MICROBIOL, V13, DOI 10.3389/fmicb.2022.984019
   Luo HY, 2021, COMMUN BIOL, V4, DOI 10.1038/s42003-021-02883-8
   Machado MV, 2014, WORLD J GASTROENTERO, V20, P12956, DOI 10.3748/wjg.v20.i36.12956
   Mansouri A, 2018, GASTROENTEROLOGY, V155, P629, DOI 10.1053/j.gastro.2018.06.083
   Masarone M, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/9547613
   Mei XD, 2019, CHIN J NAT MEDICINES, V17, P59, DOI 10.1016/S1875-5364(19)30010-X
   Meng Q, 2017, ACTA PHARMACOL SIN, V38, P69, DOI 10.1038/aps.2016.119
   Meng YY, 2019, PHARM BIOL, V57, P98, DOI 10.1080/13880209.2019.1568509
   Muzurovic E, 2021, METABOLISM, V119, DOI 10.1016/j.metabol.2021.154770
   Nassir F, 2022, BIOMOLECULES, V12, DOI 10.3390/biom12060824
   Neuschwander-Tetri BA, 2017, BMC MED, V15, DOI 10.1186/s12916-017-0806-8
   Neuschwander-Tetri BA, 2015, LANCET, V385, P956, DOI 10.1016/S0140-6736(14)61933-4
   Newsome PN, 2021, NEW ENGL J MED, V384, P1113, DOI 10.1056/NEJMoa2028395
   Nguyen P, 2008, J ANIM PHYSIOL AN N, V92, P272, DOI 10.1111/j.1439-0396.2007.00752.x
   Ni YM, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1272214
   Pan MX, 2021, J INTEGR MED-JIM, V19, P428, DOI 10.1016/j.joim.2021.07.004
   Pan MX, 2024, PHYTOMEDICINE, V130, DOI 10.1016/j.phymed.2024.155712
   Park SW, 2010, NAT MED, V16, P429, DOI 10.1038/nm.2099
   Pessayre D, 2002, AM J PHYSIOL-GASTR L, V282, pG193, DOI 10.1152/ajpgi.00426.2001
   Peverill W, 2014, INT J MOL SCI, V15, P8591, DOI 10.3390/ijms15058591
   Polyzos SA, 2017, DIABETES OBES METAB, V19, P1805, DOI 10.1111/dom.12989
   Porras D, 2017, FREE RADICAL BIO MED, V102, P188, DOI 10.1016/j.freeradbiomed.2016.11.037
   Postic C, 2008, J CLIN INVEST, V118, P829, DOI 10.1172/JCI34275
   Puri P, 2008, GASTROENTEROLOGY, V134, P568, DOI 10.1053/j.gastro.2007.10.039
   Qian F, 2024, PHYTOMEDICINE, V129, DOI 10.1016/j.phymed.2024.155691
   Qiu MY, 2020, PHYTOMEDICINE, V67, DOI 10.1016/j.phymed.2019.153140
   Ruan XF, 2024, J BIOMOL STRUCT DYN, V42, P5128, DOI 10.1080/07391102.2023.2231544
   Sanders FWB, 2016, BIOL REV, V91, P452, DOI 10.1111/brv.12178
   Sanyal AJ, 2004, CLIN GASTROENTEROL H, V2, P1107, DOI 10.1016/S1542-3565(04)00457-4
   Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929
   Schreuder TCMA, 2008, WORLD J GASTROENTERO, V14, P2474, DOI 10.3748/wjg.14.2474
   Schrieber SJ, 2011, DRUG METAB DISPOS, V39, P2182, DOI 10.1124/dmd.111.040212
   Schweiger M, 2006, J BIOL CHEM, V281, P40236, DOI 10.1074/jbc.M608048200
   Seino Y, 2010, J DIABETES INVEST, V1, P8, DOI 10.1111/j.2040-1124.2010.00022.x
   Serviddio G, 2013, FREE RADICAL BIO MED, V65, P952, DOI 10.1016/j.freeradbiomed.2013.08.174
   Shang Z, 2024, PHYTOMEDICINE, V123, DOI 10.1016/j.phymed.2023.155183
   Shao GX, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.944088
   Shen SH, 2020, CELL CYCLE, V19, P3042, DOI 10.1080/15384101.2020.1829800
   Sheng XY, 2011, AM J PHYSIOL-ENDOC M, V300, pE886, DOI 10.1152/ajpendo.00332.2010
   Shi HL, 2022, J ETHNOPHARMACOL, V296, DOI 10.1016/j.jep.2022.115477
   Shi MJ, 2019, BIOMED PHARMACOTHER, V112, DOI 10.1016/j.biopha.2019.108676
   Shi TT, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/8749564
   Song DF, 2020, BMC COMPLEMENT MED, V20, DOI 10.1186/s12906-019-2811-2
   Stefan N, 2008, ENDOCR REV, V29, P939, DOI 10.1210/er.2008-0009
   Stofan M, 2020, FRONT MED-LAUSANNE, V7, DOI 10.3389/fmed.2020.00544
   Tadic VM, 2008, J AGR FOOD CHEM, V56, P7700, DOI 10.1021/jf801668c
   Tan YY, 2023, J ETHNOPHARMACOL, V310, DOI 10.1016/j.jep.2023.116418
   Tang N, 2024, PHARMACEUTICALS-BASE, V17, DOI 10.3390/ph17040502
   Teng MLP, 2023, CLIN MOL HEPATOL, V29, pS32, DOI 10.3350/cmh.2022.0365
   ter Horst KW, 2017, CELL REP, V19, P1997, DOI 10.1016/j.celrep.2017.05.035
   Tian HJ, 2023, J ETHNOPHARMACOL, V301, DOI 10.1016/j.jep.2022.115806
   Tilg H, 2010, HEPATOLOGY, V52, P1836, DOI 10.1002/hep.24001
   van Stee MF, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0738-4
   Wang H, 2022, LIPIDS HEALTH DIS, V21, DOI 10.1186/s12944-022-01689-9
   Wang M, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0143625
   Wang YC, 2015, WORLD J GASTROENTERO, V21, P10104, DOI 10.3748/wjg.v21.i35.10104
   Winnay JN, 2010, NAT MED, V16, P438, DOI 10.1038/nm.2121
   Wu CQ, 2018, CHEM-BIOL INTERACT, V291, P111, DOI 10.1016/j.cbi.2018.06.005
   Wu YL, 2022, J CLIN TRANSL HEPATO, V10, P1050, DOI 10.14218/JCTH.2021.00458
   Xu JL, 2023, HELIYON, V9, DOI 10.1016/j.heliyon.2023.e22151
   Xu L, 2023, J TRADIT COMPL MED, V13, P325, DOI 10.1016/j.jtcme.2023.02.010
   Yan BF, 2023, J ETHNOPHARMACOL, V303, DOI 10.1016/j.jep.2022.115999
   Yang GL, 2017, EXP THER MED, V14, P4639, DOI 10.3892/etm.2017.5162
   Yang H, 2019, PHYTOTHER RES, V33, P3140, DOI 10.1002/ptr.6486
   Yang HY, 2024, ENDOCR METAB IMMUNE, V24, P691, DOI 10.2174/0118715303257018230927182802
   Yang JM, 2019, WORLD J GASTROENTERO, V25, P5105, DOI 10.3748/wjg.v25.i34.5105
   Yin JJ, 2014, J ETHNOPHARMACOL, V154, P229, DOI 10.1016/j.jep.2014.04.011
   Yoo JH, 2016, NUTRIENTS, V8, DOI 10.3390/nu8050283
   You LP, 2024, J ETHNOPHARMACOL, V329, DOI 10.1016/j.jep.2024.118165
   Younossi ZM, 2023, CLIN GASTROENTEROL H, V21, P1978, DOI 10.1016/j.cgh.2023.04.015
   Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431
   Yu XY, 2019, EUR J PHARMACOL, V864, DOI 10.1016/j.ejphar.2019.172715
   Zeng LF, 2004, EMBO J, V23, P950, DOI 10.1038/sj.emboj.7600106
   Zeng WJ, 2015, SCI REP-UK, V5, DOI 10.1038/srep16013
   Zhang BB, 2021, DIABET METAB SYND OB, V14, P4241, DOI 10.2147/DMSO.S332659
   Zhang JX, 2020, J IMMUNOL RES, V2020, DOI 10.1155/2020/3413186
   Zhang JW, 2014, SCI REP-UK, V4, DOI 10.1038/srep05832
   Zhang LL, 2017, ANN NY ACAD SCI, V1401, P90, DOI 10.1111/nyas.13381
   Zhang LX, 2019, REDOX BIOL, V26, DOI 10.1016/j.redox.2019.101284
   Zhang M, 2018, BIOSCIENCE REP, V38, DOI 10.1042/BSR20180644
   Zhang PG, 2024, ACTA BIOCH BIOPH SIN, V56, P621, DOI 10.3724/abbs.2024025
   Zhang ZL., 2018, CLIN J MED OFFIC, V46, P605, DOI [10.16680/j.1671-3826.2018.06.01, DOI 10.16680/J.1671-3826.2018.06.01]
   Zhang ZS, 2001, J NUTR BIOCHEM, V12, P144, DOI 10.1016/S0955-2863(00)00137-6
   Zhao W., 2014, Chin. J. Integr. Traditional West. Med. Dig, V22, P501, DOI [10.3969/j.issn.1671-038X.2014.09.04, DOI 10.3969/J.ISSN.1671-038X.2014.09.04]
   Zhao ZY, 2018, BIOMED ENVIRON SCI, V31, P454, DOI 10.3967/bes2018.059
   Zhao ZH, 2022, NUTRIENTS, V14, DOI 10.3390/nu14122411
   Zheng CY, 2024, J ETHNOPHARMACOL, V318, DOI 10.1016/j.jep.2023.116967
   Zhi GG, 2024, J TRADIT CHIN MED, V44, P122, DOI 10.19852/j.cnki.jtcm.20231215.001
NR 182
TC 3
Z9 3
U1 18
U2 18
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD NOV 13
PY 2024
VL 15
AR 1499602
DI 10.3389/fphar.2024.1499602
PG 23
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA N3D5Y
UT WOS:001363186900001
PM 39605910
OA gold
DA 2025-06-11
ER

PT J
AU Terenzi, DC
   Trac, JZ
   Teoh, H
   Gerstein, HC
   Bhatt, DL
   Al-Omran, M
   Verma, S
   Hess, DA
AF Terenzi, Danielle C.
   Trac, Justin Z.
   Teoh, Hwee
   Gerstein, Hertzel C.
   Bhatt, Deepak L.
   Al-Omran, Mohammed
   Verma, Subodh
   Hess, David A.
TI Vascular Regenerative Cell Exhaustion in Diabetes: Translational
   Opportunities to Mitigate Cardiometabolic Risk
SO TRENDS IN MOLECULAR MEDICINE
LA English
DT Review
ID ENDOTHELIAL PROGENITOR CELLS; BONE-MARROW MICROENVIRONMENT; INTENSIVE
   MEDICAL THERAPY; STEM-CELLS; SELF-RENEWAL; BARIATRIC SURGERY;
   CARDIOVASCULAR OUTCOMES; EXTRACELLULAR VESICLES; SIGNALING PATHWAYS;
   CRITICAL COMPONENT
AB Ischemic cardiovascular complications remain a major cause of mortality in people with type 2 diabetes (T2D). Individuals with T2D may have a reduced ability to revascularize ischemic, tissues due to abnormal production of circulating provascular progenitor cells. This 'regenerative cell exhaustion' process is intensified by increasing oxidative stress and inflammation and during T2D progression. Chronic exhaustion may be mediated by changes in the bone marrow microenvironment that dysregulate the wingless related integration site network, a central pathway maintaining the progenitor cell pool. Restoration of vascular regenerative cell production by reducing glucotoxicity with contemporary antihyperglycemic agents, by reducing systemic inflammation postbariatric surgery, or by modulating progenitor cell provascular functions using exosomal manipulation, may provide unique approaches for mitigating ischemic disease.
C1 [Terenzi, Danielle C.; Trac, Justin Z.; Teoh, Hwee; Verma, Subodh] St Michaels Hosp, Div Cardiac Surg, Toronto, ON M5B 1W8, Canada.
   [Terenzi, Danielle C.; Trac, Justin Z.; Teoh, Hwee; Al-Omran, Mohammed; Verma, Subodh] St Michaels Hosp, Keenan Res Ctr Biomed Sci, Toronto, ON M5B 1T8, Canada.
   [Terenzi, Danielle C.; Trac, Justin Z.; Teoh, Hwee; Al-Omran, Mohammed; Verma, Subodh] St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON M5B 1T8, Canada.
   [Terenzi, Danielle C.; Al-Omran, Mohammed; Verma, Subodh] Univ Toronto, Inst Med Sci, Toronto, ON M5S 1A1, Canada.
   [Trac, Justin Z.; Al-Omran, Mohammed; Verma, Subodh; Hess, David A.] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON M5S 1A8, Canada.
   [Teoh, Hwee] St Michaels Hosp, Div Endocrinol & Metab, Med Ctr, Toronto, ON M5C 2T2, Canada.
   [Gerstein, Hertzel C.] McMaster Univ & Hamilton Hlth Sci, Populat Hlth Res Inst, Div Endocrinol & Metab, Hamilton, ON L8S 4K1, Canada.
   [Bhatt, Deepak L.] Harvard Med Sch, Brigham & Womens Hosp, Heart & Vasc Ctr, Boston, MA 02115 USA.
   [Al-Omran, Mohammed; Hess, David A.] St Michaels Hosp, Div Vasc Surg, Toronto, ON M5B 1W8, Canada.
   [Al-Omran, Mohammed; Verma, Subodh] Univ Toronto, Dept Surg, Toronto, ON M5T 1P5, Canada.
   [Al-Omran, Mohammed] King Saud Univ, Dept Surg, Riyadh 11451, Saudi Arabia.
   [Hess, David A.] Western Univ, Dept Physiol & Pharmacol, London, ON N6A 5C1, Canada.
   [Hess, David A.] Western Univ, Robarts Res Inst, London, ON N6A 5B7, Canada.
C3 University of Toronto; Saint Michaels Hospital Toronto; University of
   Toronto; Saint Michaels Hospital Toronto; University of Toronto; Saint
   Michaels Hospital Toronto; Li Ka Shing Knowledge Institute; University
   of Toronto; University of Toronto; University of Toronto; Saint Michaels
   Hospital Toronto; Population Health Research Institute; McMaster
   University; McMaster University Hospital; Harvard University; Harvard
   University Medical Affiliates; Brigham & Women's Hospital; Harvard
   Medical School; University of Toronto; Saint Michaels Hospital Toronto;
   University of Toronto; King Saud University; Western University
   (University of Western Ontario); Western University (University of
   Western Ontario); University Western Ontario Hospital
RP Hess, DA (corresponding author), Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON M5S 1A8, Canada.; Hess, DA (corresponding author), St Michaels Hosp, Div Vasc Surg, Toronto, ON M5B 1W8, Canada.; Hess, DA (corresponding author), Western Univ, Dept Physiol & Pharmacol, London, ON N6A 5C1, Canada.; Hess, DA (corresponding author), Western Univ, Robarts Res Inst, London, ON N6A 5B7, Canada.
EM dhess@robarts.ca
RI Teoh, Hwee/F-2498-2018; Gerstein, Hertzel/B-1235-2013; Verma,
   Subodh/HCH-3619-2022; Hess, David/M-2828-2013; Al-Omran,
   Mohammed/IXX-0542-2023; Bhatt, Deepak L./Y-3070-2019
OI Hess, David/0000-0003-2186-3166; Bhatt, Deepak L./0000-0002-1278-6245;
   Gerstein, Hertzel/0000-0001-8072-2836
FU Canadian Institutes of Health Research; Heart and Stroke Foundation;
   Canadian Institutes of Health Research (MOP) [378189]
FX Dr Verma holds a Canada Research Chair in Cardiovascular Surgery and has
   received grants from the Canadian Institutes of Health Research and the
   Heart and Stroke Foundation. Dr Hess has received a grant from the
   Canadian Institutes of Health Research (MOP#378189).
CR Ackers I, 2018, DIABETES VASC DIS RE, V15, P3, DOI 10.1177/1479164117738442
   Adams TD, 2017, NEW ENGL J MED, V377, P1143, DOI 10.1056/NEJMoa1700459
   Ahmadzadeh A, 2016, CELL TISSUE RES, V363, P321, DOI 10.1007/s00441-015-2300-y
   Alcayaga-Miranda F, 2016, STEM CELLS INT, V2016, DOI 10.1155/2016/3409169
   Anderson JD, 2016, STEM CELLS, V34, P601, DOI 10.1002/stem.2298
   [Anonymous], 2017, IDF DIAB ALT
   Ardestani A, 2015, DIABETES CARE, V38, P659, DOI 10.2337/dc14-1751
   Asahara T, 1997, SCIENCE, V275, P964, DOI 10.1126/science.275.5302.964
   Asahara T, 1999, CIRC RES, V85, P221, DOI 10.1161/01.RES.85.3.221
   Baptista LS, 2015, WORLD J STEM CELLS, V7, P165, DOI 10.4252/wjsc.v7.i1.165
   BECKER AJ, 1963, NATURE, V197, P452, DOI 10.1038/197452a0
   Bigarella CL, 2014, DEVELOPMENT, V141, P4206, DOI 10.1242/dev.107086
   Bliss SA, 2016, CANCER RES, V76, P5832, DOI 10.1158/0008-5472.CAN-16-1092
   Butler JT, 2018, HAEMATOLOGICA, V103, P382, DOI 10.3324/haematol.2017.183335
   Cantini G, 2016, TRENDS ENDOCRIN MET, V27, P427, DOI 10.1016/j.tem.2016.03.017
   Cheng M, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-08895-7
   Cohen P, 2004, NAT REV DRUG DISCOV, V3, P479, DOI 10.1038/nrd1415
   Crisan M, 2008, CELL STEM CELL, V3, P301, DOI 10.1016/j.stem.2008.07.003
   Dangwal S, 2015, ARTERIOSCL THROM VAS, V35, P1480, DOI 10.1161/ATVBAHA.114.305048
   Drucker DJ, 2016, CELL METAB, V24, P15, DOI 10.1016/j.cmet.2016.06.009
   Dykstra B, 2008, CELL TISSUE RES, V331, P91, DOI 10.1007/s00441-007-0529-9
   Fadini GP, 2017, STEM CELLS, V35, P106, DOI 10.1002/stem.2445
   Fadini GP, 2014, STEM CELL TRANSL MED, V3, P949, DOI 10.5966/sctm.2014-0052
   Fadini GP, 2005, J AM COLL CARDIOL, V45, P1449, DOI 10.1016/j.jacc.2004.11.067
   Gerstein HC, 2019, DIABETES CARE, V42, P980, DOI 10.2337/dc18-2483
   Goktas Zeynep, 2013, Front Endocrinol (Lausanne), V4, P69, DOI 10.3389/fendo.2013.00069
   Hernandez A. F., 2018, LANCET, V6736, P1
   Hilliard TS, 2011, ANTI-CANCER DRUG, V22, P978, DOI 10.1097/CAD.0b013e32834ac8fc
   Hinnen Deborah, 2017, Diabetes Spectr, V30, P202, DOI 10.2337/ds16-0026
   Holst JJ, 2009, MOL CELL ENDOCRINOL, V297, P127, DOI 10.1016/j.mce.2008.08.012
   Hoogeboom D, 2008, J BIOL CHEM, V283, P9224, DOI 10.1074/jbc.M706638200
   Huang J, 2012, NAT MED, V18, P1778, DOI 10.1038/nm.2984
   Ibrahim A, 2016, ANNU REV PHYSIOL, V78, P67, DOI 10.1146/annurev-physiol-021115-104929
   Illán-Gómez F, 2012, OBES SURG, V22, P950, DOI 10.1007/s11695-012-0643-y
   Jin FQ, 2017, NEUROL SCI, V38, P2015, DOI 10.1007/s10072-017-3071-x
   Jin T, 2008, DIABETOLOGIA, V51, P1771, DOI 10.1007/s00125-008-1084-y
   Kaiser N, 2003, J PEDIATR ENDOCR MET, V16, P5, DOI 10.1515/JPEM.2003.16.1.5
   Keats E, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038752
   Keats EC, 2014, STEM CELLS, V32, P1649, DOI 10.1002/stem.1659
   Khat DZ, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1011-7
   Kim CH, 2010, J BLOOD MED, V1, P13, DOI 10.2147/JBM.S7224
   Laakso M, 2010, DIABETES CARE, V33, P442, DOI 10.2337/dc09-0749
   Lau D.C.W., 2018, AM J PHYSIOL-HEART C, V288, P2031
   Lechman ER, 2016, CANCER CELL, V29, P214, DOI 10.1016/j.ccell.2015.12.011
   Li YM, 2007, BIOCHEM BIOPH RES CO, V363, P209, DOI 10.1016/j.bbrc.2007.08.161
   Liu HJ, 2007, SCIENCE, V317, P803, DOI 10.1126/science.1143578
   Luft VC, 2013, DIABETOL METAB SYNDR, V5, DOI 10.1186/1758-5996-5-31
   MacDonald B.T., 2010, Dev Cell, V17, P9, DOI [DOI 10.1016/J.DEVCEL.2009.06.016.WNT, 10.1016/j.devcel.2009.06.016.Wnt/, DOI 10.1016/J.DEVCE]
   Malin SK, 2014, DIABETES OBES METAB, V16, P1230, DOI 10.1111/dom.12376
   Mangialardi G, 2014, ANTIOXID REDOX SIGN, V21, P1620, DOI 10.1089/ars.2014.5944
   Manolagas SC, 2007, MOL ENDOCRINOL, V21, P2605, DOI 10.1210/me.2007-0259
   Marseglia L, 2015, INT J MOL SCI, V16, P378, DOI 10.3390/ijms16010378
   Marso SP, 2016, NEW ENGL J MED, V375, P311, DOI 10.1056/NEJMoa1603827
   Mathivanan S, 2010, J PROTEOMICS, V73, P1907, DOI 10.1016/j.jprot.2010.06.006
   Mathiyalagan P, 2017, CIRC RES, V120, P1466, DOI 10.1161/CIRCRESAHA.116.310557
   MAUCH P, 1989, BLOOD, V74, P872
   Meng JR, 2016, STEM CELL REP, V6, P579, DOI 10.1016/j.stemcr.2016.02.002
   Mohyeldin A, 2010, CELL STEM CELL, V7, P150, DOI 10.1016/j.stem.2010.07.007
   Moore K.L., 2016, DEV HUMAN
   Moore KA, 2006, SCIENCE, V311, P1880, DOI 10.1126/science.1110542
   MOORE MAS, 1992, BLOOD, V80, P3
   Neal B., 2019, NEW ENGL J MED, V377, P644
   Oelze M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0112394
   Osorio H, 2012, OXID MED CELL LONGEV, V2012, DOI 10.1155/2012/542042
   Pal K, 2014, MOL CANCER THER, V13, P285, DOI 10.1158/1535-7163.MCT-13-0681
   Patel RS, 2015, CIRC RES, V116, P289, DOI 10.1161/CIRCRESAHA.116.304187
   Pérez LM, 2016, OBESITY, V24, P661, DOI 10.1002/oby.21405
   Pittenger MF, 1999, SCIENCE, V284, P143, DOI 10.1126/science.284.5411.143
   Porto ML, 2015, J BIOMED SCI, V22, DOI 10.1186/s12929-015-0201-8
   Qadura M, 2018, STEM CELLS, V36, P161, DOI 10.1002/stem.2751
   Rauscher FM, 2003, CIRCULATION, V108, P457, DOI 10.1161/01.CIR.0000082924.75945.48
   Reya T, 2003, NATURE, V423, P409, DOI 10.1038/nature01593
   Ring A, 2014, STEM CELL REV REP, V10, P512, DOI 10.1007/s12015-014-9515-2
   Rios C, 2016, STEM CELLS DEV, V25, P848, DOI 10.1089/scd.2015.0362
   Schauer PR, 2017, NEW ENGL J MED, V376, P641, DOI 10.1056/NEJMoa1600869
   Schauer PR, 2014, NEW ENGL J MED, V370, P2002, DOI 10.1056/NEJMoa1401329
   Shenoy A, 2014, NAT REV MOL CELL BIO, V15, P565, DOI 10.1038/nrm3854
   Shinohara A, 2014, STEM CELLS, V32, P548, DOI 10.1002/stem.1588
   SIMINOVITCH L, 1963, J CELL COMPAR PHYSL, V62, P327, DOI 10.1002/jcp.1030620313
   Steven S, 2017, REDOX BIOL, V13, P370, DOI 10.1016/j.redox.2017.06.009
   Terenzi DC, 2019, JACC-BASIC TRANSL SC, V4, P98, DOI 10.1016/j.jacbts.2018.10.005
   Thomson JA, 1998, SCIENCE, V282, P1145, DOI 10.1126/science.282.5391.1145
   Todorova D, 2017, CIRC RES, V120, P1658, DOI 10.1161/CIRCRESAHA.117.309681
   Urao N, 2012, STEM CELLS, V30, P923, DOI 10.1002/stem.1048
   Verma S, 2018, DIABETOLOGIA, V61, P2108, DOI 10.1007/s00125-018-4670-7
   Verma Subodh, 2017, CMAJ Open, V5, pE152, DOI 10.9778/cmajo.20160058
   Wang Q, 2016, EBIOMEDICINE, V11, P138, DOI 10.1016/j.ebiom.2016.08.013
   Wang SS, 2008, DEV CELL, V15, P261, DOI 10.1016/j.devcel.2008.07.002
   Wang XH, 2014, J MOL CELL CARDIOL, V74, P139, DOI 10.1016/j.yjmcc.2014.05.001
   Werner N, 2007, BASIC RES CARDIOL, V102, P565, DOI 10.1007/s00395-007-0680-1
   Wiviott SD, 2019, NEW ENGL J MED, V380, P347, DOI [10.1056/NEJMoa1812389, 10.1056/NEJMc1902837]
   Xie XY, 2011, MED SCI MONITOR, V17, pBR35, DOI 10.12659/MSM.881383
   Xie Y, 2017, J CELL MOL MED, V21, P1033, DOI 10.1111/jcmm.13039
   Zinman B, 2015, NEW ENGL J MED, V373, P2117, DOI 10.1056/NEJMoa1504720
NR 94
TC 21
Z9 24
U1 0
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1471-4914
EI 1471-499X
J9 TRENDS MOL MED
JI Trends Mol. Med
PD JUL
PY 2019
VL 25
IS 7
BP 640
EP 655
DI 10.1016/j.molmed.2019.03.006
PG 16
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
   Medicine
GA IH2YQ
UT WOS:000474360900008
PM 31053416
DA 2025-06-11
ER

PT J
AU Rutledge, T
   Linke, SE
   Johnson, BD
   Bittner, V
   Krantz, DS
   Cornell, CE
   Vaccarino, V
   Pepine, CJ
   Handberg, EM
   Eteiba, W
   Shaw, LJ
   Parashar, S
   Eastwood, JA
   Vido, DA
   Merz, CNB
AF Rutledge, Thomas
   Linke, Sarah E.
   Johnson, B. Delia
   Bittner, Vera
   Krantz, David S.
   Cornell, Carol E.
   Vaccarino, Viola
   Pepine, Carl J.
   Handberg, Eileen M.
   Eteiba, Wafia
   Shaw, Leslee J.
   Parashar, Susmita
   Eastwood, Jo-Ann
   Vido, Diane A.
   Merz, C. Noel Bairey
TI Relationships Between Cardiovascular Disease Risk Factors and Depressive
   Symptoms as Predictors of Cardiovascular Disease Events in Women
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
ID CORONARY-HEART-DISEASE; SYNDROME EVALUATION WISE; MYOCARDIAL-INFARCTION;
   52 COUNTRIES; POSTMENOPAUSAL WOMEN; METABOLIC SYNDROME;
   DIABETES-MELLITUS; OLDER-ADULTS; NHANES-I; ASSOCIATION
AB Background: Modifiable risk factors for cardiovascular disease (CVD) account for much of the variability in CVD outcomes and are also related to psychosocial variables. There is evidence that depression can undermine the treatment and advance the progression of CVD risk factors, suggesting that CVD risk factor relationships with CVD events may differ among those with depression.
   Methods: This study tracked CVD events and mortality over a median of 5.9 years among a prospective cohort of 620 women (mean age 59.6 years [11.6]) completing a diagnostic protocol including coronary angiography and CVD risk factor assessment. Depressive symptoms were assessed using the Beck Depression Inventory (BDI). The study outcome was combined cardiovascular mortality and events.
   Results: Over the follow-up interval, 16.1% of the sample experienced one or more of the cardiovascular outcomes. In separate Cox regression models adjusting for age, education history, ethnicity, and coronary angiogram scores, we observed statistically significant CVD risk factor x BDI score interactions for diabetes, smoking, and waist-hip ratio factors. Simple effect analyses indicated that diabetes and smoking status were more strongly associated with cardiovascular outcomes among participants with lower BDI scores, whereas waist-hip ratio values predicted outcomes only among those with higher BDI scores.
   Conclusions: These results suggest that the relationship between modifiable CVD risk factors and CVD outcomes may vary with depression status in clinical samples of women. This evidence augments prior research by demonstrating that depression may influence CVD risk jointly with or independent of CVD risk factors. It also provides further support for the inclusion of depression assessment in cardiovascular clinic settings.
C1 [Rutledge, Thomas] VA San Diego Healthcare Syst, Psychol Serv 116B, Med Ctr, San Diego, CA 92161 USA.
   [Rutledge, Thomas] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.
   [Linke, Sarah E.] Univ Calif San Diego, San Diego State Univ, San Diego Joint Doctoral Program Clin Psychol, San Diego, CA 92103 USA.
   [Johnson, B. Delia; Eteiba, Wafia] Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA USA.
   [Bittner, Vera] Univ Alabama, Dept Med, Birmingham, AL 35294 USA.
   [Krantz, David S.] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA.
   [Cornell, Carol E.] Univ Arkansas Med Sci, Dept Hlth Behav & Hlth Educ, Little Rock, AR 72205 USA.
   [Vaccarino, Viola; Parashar, Susmita] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA.
   [Pepine, Carl J.; Handberg, Eileen M.] Univ Florida, Gainesville, FL USA.
   [Shaw, Leslee J.] Univ Arkansas Med Sci, Dept Med, Little Rock, AR 72205 USA.
   [Eastwood, Jo-Ann] Univ Calif Los Angeles, Sch Nursing, Los Angeles, CA 90024 USA.
   [Vido, Diane A.] Allegheny Gen Hosp, Pittsburgh, PA 15212 USA.
   [Merz, C. Noel Bairey] Cedars Sinai Heart Inst, Womens Heart Ctr, Los Angeles, CA USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA San Diego Healthcare System; University of California System;
   University of California San Diego; University of California System;
   University of California San Diego; California State University System;
   San Diego State University; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh; University of Alabama
   System; University of Alabama Birmingham; Uniformed Services University
   of the Health Sciences - USA; University of Arkansas System; University
   of Arkansas Medical Sciences; Emory University; Rollins School Public
   Health; State University System of Florida; University of Florida;
   University of Arkansas System; University of Arkansas Medical Sciences;
   University of California System; University of California Los Angeles;
   Allegheny Health Network; Allegheny General Hospital; Cedars Sinai
   Medical Center
RP Rutledge, T (corresponding author), VA San Diego Healthcare Syst, Psychol Serv 116B, Med Ctr, 3350 La Jolla Village Dr, San Diego, CA 92161 USA.
EM thomas.rutledge@va.gov
RI Krantz, David/L-5364-2015; Vaccarino, Viola/AAW-5600-2020; Parashar,
   Susmita/GYJ-3885-2022; Shaw, Leslee/ABG-4621-2022
OI Krantz, David/0000-0002-1671-1355; Bittner, Vera/0000-0001-9456-850X;
   Handberg, Eileen/0000-0002-7805-9577; Vaccarino, Laura
   Viola/0000-0002-9054-0654
FU National Heart, Lung and Blood Institutes [N01-HV-68161, N01-HV-68162,
   N01-HV-68163, N01-HV-68164, U0164829, U01 HL649141, U01 HL649241];
   National Center for Research Resources [MO1-RR00425]; Gustavus and Louis
   Pfeiffer Research Foundation, Denville, New Jersey; Women's Guild of
   Cedars-Sinai Medical Center, Los Angeles, California; Ladies Hospital
   Aid Society of Western Pennsylvania, Pittsburgh, Pennsylvania; Edythe
   Broad Endowment for Women's Heart Research, Los Angeles, California
FX This work was supported by contracts from the National Heart, Lung and
   Blood Institutes (N01-HV-68161, N01-HV-68162, N01-HV-68163,
   N01-HV-68164) and grants (U0164829, U01 HL649141, U01 HL649241), a
   General Clinical Research Center grant (MO1-RR00425) from the National
   Center for Research Resources, and grants from the Gustavus and Louis
   Pfeiffer Research Foundation, Denville, New Jersey; The Women's Guild of
   Cedars-Sinai Medical Center, Los Angeles, California; The Ladies
   Hospital Aid Society of Western Pennsylvania, Pittsburgh, Pennsylvania;
   and The Edythe Broad Endowment for Women's Heart Research, Los Angeles,
   California. The first author takes full responsibility for the accuracy
   of the statistical results and all authors had access to the WISE data.
   All authors contributed to the development of this manuscript in
   important ways, including study design, data collection, participating
   in multiple internal drafts for editorial purposes, group discussion of
   findings, and data analysis. The article received approval for
   publication by the WISE P&P committee and the participating authors.
CR [Anonymous], DEPRESSION INVENTORY
   [Anonymous], AM J PUBLIC HEALTH
   [Anonymous], JAMA
   Barth J, 2004, PSYCHOSOM MED, V66, P802, DOI 10.1097/01.psy.0000146332.53619.b2
   Beck A.T., 1979, COGNITIVE THERAPY DE
   Carnethon MR, 2007, ARCH INTERN MED, V167, P802, DOI 10.1001/archinte.167.8.802
   Davidson KW, 2010, ARCH INTERN MED, V170, P600, DOI 10.1001/archinternmed.2010.29
   de Groot M, 2001, PSYCHOSOM MED, V63, P619, DOI 10.1097/00006842-200107000-00015
   Feinstein Robert E, 2006, Cardiol Rev, V14, P164, DOI 10.1097/01.crd.0000200977.41695.43
   Ferketich AK, 2000, ARCH INTERN MED, V160, P1261, DOI 10.1001/archinte.160.9.1261
   Georgiades A, 2007, PSYCHOSOM MED, V69, P235, DOI 10.1097/PSY.0b013e318042588d
   He J, 2001, ARCH INTERN MED, V161, P996, DOI 10.1001/archinte.161.7.996
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Kessler RC, 2007, ANNU REV CLIN PSYCHO, V3, P137, DOI 10.1146/annurev.clinpsy.3.022806.091444
   Khot UN, 2003, JAMA-J AM MED ASSOC, V290, P898, DOI 10.1001/jama.290.7.898
   Kim Ji-yeong, 2007, J Prev Med Public Health, V40, P191
   Kjelsberg MO, 1996, CIRCULATION, V94, P946
   Le Trong K, 2006, Cost Eff Resour Alloc, V4, P18, DOI 10.1186/1478-7547-4-18
   Levine MD, 2003, NICOTINE TOB RES, V5, P69, DOI 10.1080/1462220021000060455
   Lichtman JH, 2008, CIRCULATION, V118, P1768, DOI 10.1161/CIRCULATIONAHA.108.190769
   Mahoney EM, 2002, JAMA-J AM MED ASSOC, V288, P1851, DOI 10.1001/jama.288.15.1851
   Merz CNB, 1999, J AM COLL CARDIOL, V33, P1453
   MILLER VT, 1995, JAMA-J AM MED ASSOC, V273, P199, DOI 10.1001/jama.1995.03520270033028
   Musselman DL, 1998, ARCH GEN PSYCHIAT, V55, P580, DOI 10.1001/archpsyc.55.7.580
   Nguyen HQ, 2008, AM J PREV MED, V35, P111, DOI 10.1016/j.amepre.2008.04.014
   Oh K, 2005, AM J EPIDEMIOL, V161, P161, DOI 10.1093/aje/kwi026
   Olfson M, 2002, JAMA-J AM MED ASSOC, V287, P203, DOI 10.1001/jama.287.2.203
   Rosengren A, 2004, LANCET, V364, P953, DOI 10.1016/S0140-6736(04)17019-0
   Rozanski A, 1999, CIRCULATION, V99, P2192, DOI 10.1161/01.CIR.99.16.2192
   Rumsfeld JS, 2005, CIRCULATION, V111, P250, DOI 10.1161/01.CIR.0000154573.62822.89
   Sharaf BL, 2001, AM J CARDIOL, V87, P937, DOI 10.1016/S0002-9149(01)01424-2
   Sherwood A, 2007, ARCH INTERN MED, V167, P367, DOI 10.1001/archinte.167.4.367
   Treiber FA, 2003, PSYCHOSOM MED, V65, P46, DOI 10.1097/00006842-200301000-00007
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
   Vaccarino V, 2007, J AM COLL CARDIOL, V50, P2044, DOI 10.1016/j.jacc.2007.07.069
   van Melle JP, 2004, PSYCHOSOM MED, V66, P814, DOI 10.1097/01.psy.0000146294.82810.9c
   Wassertheil-Smoller S, 2004, ARCH INTERN MED, V164, P289, DOI 10.1001/archinte.164.3.289
   Williams JW, 2002, JAMA-J AM MED ASSOC, V287, P1160, DOI 10.1001/jama.287.9.1160
   Yusuf S, 2005, LANCET, V366, P1640, DOI 10.1016/S0140-6736(05)67663-5
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
NR 40
TC 29
Z9 34
U1 0
U2 8
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
J9 J WOMENS HEALTH
JI J. Womens Health
PD FEB
PY 2012
VL 21
IS 2
BP 133
EP 139
DI 10.1089/jwh.2011.2787
PG 7
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal; Obstetrics & Gynecology; Women's Studies
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal
   Medicine; Obstetrics & Gynecology; Women's Studies
GA 891TV
UT WOS:000300240400005
PM 21988550
OA Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Giusti, L
   Bianchini, V
   Aggio, A
   Mammarella, S
   Salza, A
   Necozione, S
   Alunno, A
   Ferri, C
   Casacchia, M
   Roncone, R
AF Giusti, Laura
   Bianchini, Valeria
   Aggio, Annalisa
   Mammarella, Silvia
   Salza, Anna
   Necozione, Stefano
   Alunno, Alessia
   Ferri, Claudio
   Casacchia, Massimo
   Roncone, Rita
TI Twelve-month outcomes in overweight/obese users with mental disorders
   following a multi-element treatment including diet, physical activity,
   and positive thinking: The real-world "An Apple a Day" controlled trial
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE diet protocol; physical activity; metacognitive group intervention;
   cardiovascular risk; mental disorders; obesity; metabolic syndrome;
   psychopharmacological treatment
ID MAJOR DEPRESSIVE DISORDER; INDUCED WEIGHT-GAIN; QUALITY-OF-LIFE;
   RISK-FACTORS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   SCHIZOAFFECTIVE DISORDER; BIPOLAR DISORDER; BODY-WEIGHT; HEALTH
AB The present study aimed to evaluate the 12-month effectiveness of a real-world weight loss transdiagnostic intervention in overweight/obese participants affected by mental disorders under psychopharmacological treatment. We conducted a real-world, controlled, pragmatic outpatient trial. We allocated 58 overweight/obese adults under psychopharmacological treatment from a mental health outpatient unit and 48 overweight/obese adults from a cardiovascular prevention outpatient unit, and assigned them to an intervention or treatment usual as condition (TAU) enriched by life-style advice. Participants in both intervention groups took part in a diet programme (the modified OMNIHeart dietary protocol) and monitoring of regular aerobic activity. A brief group programme ("An Apple a Day" Metacognitive Training, Apple-MCT) was added in the intervention group of participants affected by mental disorders. The primary outcome was weight loss. Secondary outcomes included anthropometric, clinical, and metabolic variables. Psychopathology and health-related quality of life were also evaluated in the psychiatric sample. At 12 months, both intervention groups showed a more marked mean decrease in weight (6.7 kg, SD: 3.57) than the TAU group (0.32 kg, SD: 1.96), and a statistically significant improvement in metabolic variables compared with the control groups. Furthermore, the participants affected by mental disorders included in the intervention group reported improved health-related quality of life. Our findings suggest the need to implement integrated interventions based on a dietary protocol, physical activity, and modification of cognitive style in overweight/obese users with mental disorders.
C1 [Giusti, Laura; Bianchini, Valeria; Aggio, Annalisa; Mammarella, Silvia; Salza, Anna; Necozione, Stefano; Casacchia, Massimo] Univ LAquila, Dept Life Hlth & Environm Sci, LAquila, Italy.
   [Alunno, Alessia; Ferri, Claudio] Univ LAquila, San Salvatore Hosp, Sch Internal Med, Dept Life, LAquila, Italy.
   [Roncone, Rita] Univ LAquila, San Salvatore Hosp, Univ Unit Rehabil Treatment, Dept Life Hlth & Environm Sci,Early Intervent Ment, LAquila, Italy.
C3 University of L'Aquila; University of L'Aquila; University of L'Aquila
RP Roncone, R (corresponding author), Univ LAquila, San Salvatore Hosp, Univ Unit Rehabil Treatment, Dept Life Hlth & Environm Sci,Early Intervent Ment, LAquila, Italy.
EM rita.roncone@univaq.it
RI Giusti, Laura/AGF-0849-2022; Roncone, Rita/H-3095-2012; Alunno,
   Alessia/AAC-8842-2022; Salza, Anna/IQR-9478-2023; Mammarella,
   Silvia/IQR-9276-2023
OI Mammarella, Silvia/0009-0008-2045-5981; Alunno,
   Alessia/0000-0003-1105-5640; Casacchia, Massimo/0000-0003-1015-3919
CR Allison DB, 2003, PSYCHIAT SERV, V54, P565, DOI 10.1176/appi.ps.54.4.565
   Allison DB, 2001, J CLIN PSYCHIAT, V62, P22
   Alonso-Pedrero L, 2019, OBES REV, V20, P1680, DOI 10.1111/obr.12934
   Alvarez-Jiménez M, 2008, BRIT J PSYCHIAT, V193, P101, DOI 10.1192/bjp.bp.107.042853
   Annesi James J, 2011, Perm J, V15, P23
   [Anonymous], 2004, J CLIN PSYCHIAT, V65, P267
   [Anonymous], 2008, SCHIZOPHR RES, DOI DOI 10.1016/S0920-9964(08)70491-2
   [Anonymous], 2015, Guideline: sugars intake for adults and children
   Apolone G, 1998, J CLIN EPIDEMIOL, V51, P1025, DOI 10.1016/S0895-4356(98)00094-8
   Association AP, 2013, Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
   Attux C, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-60
   Bartoli F, 2015, EUR NEUROPSYCHOPHARM, V25, P1767, DOI 10.1016/j.euroneuro.2015.06.011
   Bartoli F, 2015, J PSYCHIATR RES, V66-67, P127, DOI 10.1016/j.jpsychires.2015.04.028
   Beck AT, 2004, SCHIZOPHR RES, V68, P319, DOI 10.1016/s0920-9964(03)00189-0
   Bioque M, 2018, SCHIZOPHR RES, V193, P188, DOI 10.1016/j.schres.2017.06.032
   Blaine B, 2008, J HEALTH PSYCHOL, V13, P1190, DOI 10.1177/1359105308095977
   Bonfioli E, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-78
   Briguglio M, 2020, NEUROPSYCH DIS TREAT, V16, P55, DOI 10.2147/NDT.S229206
   Buckley PF, 2005, SCHIZOPHR RES, V79, P281, DOI 10.1016/j.schres.2005.04.010
   Caemmerer J, 2012, SCHIZOPHR RES, V140, P159, DOI 10.1016/j.schres.2012.03.017
   Carey VJ, 2005, CLIN TRIALS, V2, P529, DOI 10.1191/1740774505cn123oa
   Carrà G, 2014, SOC PSYCH PSYCH EPID, V49, P1739, DOI 10.1007/s00127-014-0835-y
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cohn TA, 2006, CAN J PSYCHIAT, V51, P492, DOI 10.1177/070674370605100804
   Cosan AS, 2021, BRAIN BEHAV, V11, DOI 10.1002/brb3.1912
   Daumit GL, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.7247
   Daumit GL, 2013, NEW ENGL J MED, V368, P1594, DOI 10.1056/NEJMoa1214530
   Dayabandara M, 2017, NEUROPSYCH DIS TREAT, V13, DOI 10.2147/NDT.S113099
   De Hert M, 2006, Clin Pract Epidemiol Ment Health, V2, P14
   De Hert M, 2009, EUR PSYCHIAT, V24, P412, DOI 10.1016/j.eurpsy.2009.01.005
   De Hert M, 2006, SCHIZOPHR RES, V88, P222, DOI 10.1016/j.schres.2006.07.025
   De Hert M, 2012, CNS DRUGS, V26, P733, DOI 10.2165/11634500-000000000-00000
   Deenik J, 2019, SCHIZOPHR RES, V204, P360, DOI 10.1016/j.schres.2018.07.033
   Di Renzo L, 2020, J TRANSL MED, V18, DOI 10.1186/s12967-020-02399-5
   Faulkner G, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005148.pub2
   Firth J, 2016, PSYCHOL MED, V46, P2869, DOI 10.1017/S0033291716001732
   Firth J, 2017, SCHIZOPHRENIA BULL, V43, P546, DOI 10.1093/schbul/sbw115
   Gallagher P, 2021, EARLY INTERV PSYCHIA, V15, P367, DOI 10.1111/eip.12965
   Gentil L, 2017, J CLIN HYPERTENS, V19, P75, DOI 10.1111/jch.12869
   Graham I, 2007, EUR HEART J, V28, P2375, DOI 10.1093/eurheartj/ehm316
   Grundy SM, 2005, J AM COLL CARDIOL, V46, P173, DOI 10.1016/j.jacc.2005.05.007
   Guertin C, 2017, MOTIV EMOTION, V41, P294, DOI 10.1007/s11031-017-9608-8
   Hampton JN, 2018, STRESS HEALTH, V34, P591, DOI 10.1002/smi.2819
   Hasnain M, 2009, PRIM CARE DIABETES, V3, P5, DOI 10.1016/j.pcd.2008.10.005
   Jakobsen AS, 2018, SCHIZOPHR RES, V199, P109, DOI 10.1016/j.schres.2018.03.016
   JETTE M, 1990, CLIN CARDIOL, V13, P555, DOI 10.1002/clc.4960130809
   Kahl KG, 2016, J AFFECT DISORDERS, V192, P91, DOI 10.1016/j.jad.2015.12.015
   Kamaradova D, 2016, PATIENT PREFER ADHER, V10, P1289, DOI 10.2147/PPA.S99136
   Kawauchi IM, 2017, J NUTR SCI, V6, DOI 10.1017/jns.2017.41
   Kolotkin RL, 2001, OBES RES, V9, P564, DOI 10.1038/oby.2001.73
   Komossa K, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006625.pub2
   Lasikiewicz N, 2014, APPETITE, V72, P123, DOI 10.1016/j.appet.2013.09.017
   Latas M, 2019, CURR OPIN PSYCHIATR, V32, P429, DOI 10.1097/YCO.0000000000000527
   Laursen TM, 2011, SCHIZOPHR RES, V131, P101, DOI 10.1016/j.schres.2011.06.008
   Lee SH, 2018, PSYCHIAT INVEST, V15, P811, DOI 10.30773/pi.2018.04.15.1
   Li C, 2019, J CLIN PSYCHIAT, V80, DOI 10.4088/JCP.18m12422
   Looijmans A, 2019, BMC PSYCHIATRY, V19, DOI 10.1186/s12888-019-2310-5
   Masa-Font R, 2015, EUR PSYCHIAT, V30, P1028, DOI 10.1016/j.eurpsy.2015.09.006
   Mazereel V, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.573479
   Mizock L, 2012, PSYCHIATR REHABIL J, V35, P466, DOI 10.1037/h0094581
   Moise N, 2014, JAMA INTERN MED, V174, P818, DOI 10.1001/jamainternmed.2014.115
   Moritz S, 2010, CURR OPIN PSYCHIATR, V23, P561, DOI 10.1097/YCO.0b013e32833d16a8
   Mucheru Doreen, 2019, JBI Database System Rev Implement Rep, V17, P1770, DOI 10.11124/JBISRIR-2017-003943
   Naslund JA, 2017, GEN HOSP PSYCHIAT, V47, P83, DOI 10.1016/j.genhosppsych.2017.04.003
   Nenke MA, 2015, SCHIZOPHR RES, V161, P465, DOI 10.1016/j.schres.2014.12.012
   Newcomer John W, 2004, J Clin Psychopharmacol, V24, pS1, DOI 10.1097/01.jcp.0000142281.85207.d5
   NUGENT WR, 1993, RES SOCIAL WORK PRAC, V3, P191, DOI 10.1177/104973159300300205
   Olker SJ, 2016, AM J PSYCHIATR REHAB, V19, P370, DOI 10.1080/15487768.2016.1231643
   Domecq JP, 2015, J CLIN ENDOCR METAB, V100, P363, DOI 10.1210/jc.2014-3421
   Paton C, 2004, ACTA PSYCHIAT SCAND, V110, P299, DOI 10.1111/j.1600-0447.2004.00372.x
   Pedersen S, 2018, SOC SCI MED, V208, P18, DOI 10.1016/j.socscimed.2018.05.016
   Pedley R, 2018, BMC PSYCHIATRY, V18, DOI 10.1186/s12888-018-1692-0
   Pereira MA, 2004, JAMA-J AM MED ASSOC, V292, P2482, DOI 10.1001/jama.292.20.2482
   Poggio R, 2019, AM J PREV MED, V57, P438, DOI 10.1016/j.amepre.2019.05.011
   Powell LH, 2007, AM PSYCHOL, V62, P234, DOI 10.1037/0003-066X.62.3.234
   Qiu WX, 2021, FRONT NEUROSCI-SWITZ, V15, DOI 10.3389/fnins.2021.728810
   Ratchford SM, 2019, AM J PHYSIOL-HEART C, V317, pH1194, DOI 10.1152/ajpheart.00431.2019
   Reekie J, 2015, OBES REV, V16, P566, DOI 10.1111/obr.12284
   Roncone R, 1999, ACTA PSYCHIAT SCAND, V100, P229, DOI 10.1111/j.1600-0447.1999.tb10850.x
   Rosenbaum S, 2014, J CLIN PSYCHIAT, V75, P964, DOI 10.4088/JCP.13r08765
   Sahle BW, 2019, BMC PSYCHIATRY, V19, DOI 10.1186/s12888-019-2385-z
   Saxena S, 2017, WORLD PSYCHIATRY, V16, P1, DOI 10.1002/wps.20403
   Schwalm JD, 2019, LANCET, V394, P1231, DOI 10.1016/S0140-6736(19)31949-X
   Seal A, 2022, OBESITY, V30, P240, DOI 10.1002/oby.23293
   Smith J, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.564240
   Smith PJ, 2010, PSYCHOSOM MED, V72, P239, DOI 10.1097/PSY.0b013e3181d14633
   Sperling JD, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.759694
   Stapel B, 2022, FRONT PSYCHIATRY, V13, DOI 10.3389/fpsyt.2022.831358
   Streppel MT, 2005, ARCH INTERN MED, V165, P150, DOI 10.1001/archinte.165.2.150
   Stubbs B, 2018, EUR PSYCHIAT, V54, P124, DOI 10.1016/j.eurpsy.2018.07.004
   Tacchi MJ, 2019, EARLY INTERV PSYCHIA, V13, P1310, DOI 10.1111/eip.12783
   Tumiel E, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00566
   Ussorio D, 2016, PSYCHOL PSYCHOTHER-T, V89, P50, DOI 10.1111/papt.12059
   van Winkel R, 2006, J CLIN PSYCHIAT, V67, P1493, DOI 10.4088/JCP.v67n1002
   Vancampfort D, 2017, PSYCHIAT RES, V258, P250, DOI 10.1016/j.psychres.2017.08.041
   Vancampfort D, 2017, WORLD PSYCHIATRY, V16, P308, DOI 10.1002/wps.20458
   Ventura J., 1993, INT J METHODS PSYCHI, V3, p221 244
   Volpe M, 2022, HIGH BLOOD PRESS CAR, V29, P91, DOI 10.1007/s40292-021-00503-4
   Waltz JA, 2017, NEUROSCIENCE, V345, P203, DOI 10.1016/j.neuroscience.2016.06.005
   Waterreus AJ, 2009, MED J AUSTRALIA, V190, P185, DOI 10.5694/j.1326-5377.2009.tb02344.x
   Weber M, 2006, SCHIZOPHR RES, V83, P95, DOI 10.1016/j.schres.2006.01.008
   Weiden PJ, 2004, SCHIZOPHR RES, V66, P51, DOI 10.1016/S0920-9964(02)00498-X
   Wells A, 2021, CIRCULATION, V144, P23, DOI 10.1161/CIRCULATIONAHA.120.052428
   Wilson C, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2020-044977
   Zachary Z, 2020, OBES RES CLIN PRACT, V14, P210, DOI 10.1016/j.orcp.2020.05.004
   ,, 2010, Global recommendations on physical activity for health
NR 106
TC 4
Z9 4
U1 1
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD AUG 23
PY 2022
VL 13
AR 903759
DI 10.3389/fpsyt.2022.903759
PG 20
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 5O6LV
UT WOS:000872583200001
PM 36081460
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Centorrino, F
   Mark, TL
   Talamo, A
   Oh, K
   Chang, J
AF Centorrino, Franca
   Mark, Tami L.
   Talamo, Alessandra
   Oh, Kelly
   Chang, Jane
TI Health and Economic Burden of Metabolic Comorbidity Among Individuals
   With Bipolar Disorder
SO JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
LA English
DT Article
DE bipolar disorder; diabetes; angina; dyslipidemia; hypertension;
   metabolic syndrome; metabolic comorbidity; medical comorbidity; burden
ID MAJOR DEPRESSION; MEDICAL BURDEN; I DISORDER; POPULATION; PREVALENCE;
   OVERWEIGHT; MORTALITY; ILLNESS; OBESITY; COSTS
AB Objectives: To compare the prevalence and health care costs of metabolic conditions in patients with bipolar disorder to age- and sex-matched control patients using a large insurance claims database.
   Methods: A retrospective analysis of medical service and prescription claims from the Thomson Reuters (Healthcare) MarketScan Commercial Database (which includes claims information on >12 million employees with employer-based insurance and their dependents in the United States) was conducted. Claims data for 28,53 1 patients with bipolar disorder were compared for 1 year with data for 85,593 age- and sex-matched control patients with no mental health disorders and no psychotropic medication use.
   Results: Patients with bipolar disorder had a significantly higher prevalence of metabolic comorbidities than the general population (37% vs 30%, P < 0.0001), and annual medical service treatment costs for metabolic conditions were twice that of the control cohort ($531 vs $233, P < 0.0001). The bipolar cohort had significantly higher overall medical service and prescription drug costs than those of the control cohort ($12,764 vs $3,140, P < 0.0001). Prescription medication cost's for metabolic conditions were higher as well, with bipolar cohort per-patient costs of $571 versus $301 for the control cohort (P < 0.0001).
   Conclusions: Patients with bipolar disorder have significantly more metabolic comorbidities and higher medical costs than age- and sex-matched controls. Studies that link claims data with medical records or primary data collection pertaining to metabolic conditions may overcome limitations in the diagnostic information and Outcome predictors. To reduce the medical and economic burden of bipolar disorder, strategies should be identified to prevent the development of metabolic comorbidities and improve medication adherence.
C1 [Centorrino, Franca; Talamo, Alessandra] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA.
   [Centorrino, Franca; Talamo, Alessandra] McLean Hosp, Schizophrenia Bipolar Disorder Program, Belmont, MA 02178 USA.
   [Centorrino, Franca; Talamo, Alessandra] McLean Hosp, Psychopharmacol Program, Belmont, MA 02178 USA.
   [Mark, Tami L.; Oh, Kelly] Thomson Healthcare, Washington, DC USA.
   [Chang, Jane] Novartis Pharmaceut, E Hanover, NJ USA.
C3 Harvard University; Harvard Medical School; Harvard University; Harvard
   University Medical Affiliates; McLean Hospital; Harvard University;
   Harvard University Medical Affiliates; McLean Hospital; Novartis;
   Novartis USA
RP Centorrino, F (corresponding author), Massachusetts Gen Hosp, McLean Div, Schizophrenia Bipolar Disorder Program, Belmont, MA 02478 USA.
EM fcentorrino@mclean.harvard.edu
RI Talamo, Alessandra/GRN-8346-2022
OI Talamo, Alessandra/0000-0001-7321-9247
FU Thomson Healthcare; Novartis Pharmaceuticals Corporation
FX This study was supported in part by access to MarketScan data provided
   by Thomson Healthcare, 4301 Connecticut Ave NW, Suite 330, Washington,
   DC 20008. Funding for this article was provided by Novartis
   Pharmaceuticals Corporation, One Health Plaza, East Hanover. NJ 07936.
CR Angst F, 2002, J AFFECT DISORDERS, V68, P167, DOI 10.1016/S0165-0327(01)00377-9
   Basu R, 2004, BIPOLAR DISORD, V6, P314, DOI 10.1111/j.1399-5618.2004.00126.x
   Bryant-Comstock L, 2002, BIPOLAR DISORD, V4, P398, DOI 10.1034/j.1399-5618.2002.01148.x
   Carney CP, 2006, PSYCHOSOM MED, V68, P684, DOI 10.1097/01.psy.0000237316.09601.88
   Cassidy F, 1999, AM J PSYCHIAT, V156, P1417
   Centorrino F, 2001, PSYCHIATR SERV, V52, P378, DOI 10.1176/appi.ps.52.3.378
   Centorrino F, 2006, INT J OBESITY, V30, P1011, DOI 10.1038/sj.ijo.0803222
   Colom F, 2005, BIPOLAR DISORD, V7, P24, DOI 10.1111/j.1399-5618.2005.00248.x
   Dean BB, 2004, CURR MED RES OPIN, V20, P139, DOI 10.1185/030079903125002801
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   Gardner HH, 2006, J CLIN PSYCHIAT, V67, P1209, DOI 10.4088/JCP.v67n0806
   Grant BF, 2004, ARCH GEN PSYCHIAT, V61, P1107, DOI 10.1001/archpsyc.61.11.1107
   Johannessen L, 2006, J AFFECT DISORDERS, V95, P13, DOI 10.1016/j.jad.2006.03.027
   Judd LL, 2002, ARCH GEN PSYCHIAT, V59, P530, DOI 10.1001/archpsyc.59.6.530
   Katon WJ, 2003, BIOL PSYCHIAT, V54, P216, DOI 10.1016/S0006-3223(03)00273-7
   Keck PE, 2003, J CLIN PSYCHIAT, V64, P1426, DOI 10.4088/JCP.v64n1205
   Kessler RC, 2005, ARCH GEN PSYCHIAT, V62, P617, DOI 10.1001/archpsyc.62.6.617
   Kilbourne AM, 2004, BIPOLAR DISORD, V6, P368, DOI 10.1111/j.1399-5618.2004.00138.x
   Kilbourne Amy M, 2005, Curr Psychiatry Rep, V7, P471, DOI 10.1007/s11920-005-0069-5
   Kupfer DJ, 2005, JAMA-J AM MED ASSOC, V293, P2528, DOI 10.1001/jama.293.20.2528
   McElroy SL, 2002, J CLIN PSYCHIAT, V63, P207, DOI 10.4088/JCP.v63n0306
   Ösby U, 2001, ARCH GEN PSYCHIAT, V58, P844, DOI 10.1001/archpsyc.58.9.844
   Soreca I, 2009, DEPRESS ANXIETY, V26, P73, DOI 10.1002/da.20521
   Taylor V, 2006, J CLIN PSYCHIAT, V67, P1034, DOI 10.4088/JCP.v67n0704
   Vornik LA, 2006, J CLIN PSYCHIAT, V67, P24
   Weissman MM, 1996, JAMA-J AM MED ASSOC, V276, P293, DOI 10.1001/jama.276.4.293
   WYATT RJ, 1995, SOC PSYCH PSYCH EPID, V30, P213
NR 28
TC 42
Z9 43
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0271-0749
J9 J CLIN PSYCHOPHARM
JI J. Clin. Psychopharmacol.
PD DEC
PY 2009
VL 29
IS 6
BP 595
EP 600
DI 10.1097/JCP.0b013e3181bef8a6
PG 6
WC Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Psychiatry
GA 522NG
UT WOS:000272004300014
PM 19910727
DA 2025-06-11
ER

PT J
AU Sheikh, MA
AF Sheikh, Mashhood Ahmed
TI Child maltreatment, psychopathological symptoms, and onset of diabetes
   mellitus, hypothyroidism and COPD in adulthood
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Diabetes mellitus; Hypothyroidism; Low metabolism; Chronic bronchitis;
   Emphysema; COPD; Childhood maltreatment; Social epidemiology; Social
   causation; Life course
ID EARLY-LIFE ADVERSITY; PSYCHOLOGICAL DISTRESS; MYOCARDIAL-INFARCTION;
   INFLAMMATORY MARKERS; METABOLIC SYNDROME; ALLOSTATIC LOAD; RISK-FACTOR;
   ABUSE; DEPRESSION; HEALTH
AB Background: The aim of this study was to assess the associations between child maltreatment (CM), psychopathological symptoms, and onset of diabetes mellitus, hypothyroidism (i.e., low metabolism), and chronic bronchitis/emphysema/COPD in adulthood.
   Methods: The present analysis used cross-sectional data collected in 2007-2008 within the Troms phi Study, Norway (N = 12,981). CM was measured with a single item, and self-reported information on psychopathological symptoms and physical health outcomes was used. The associations between CM, psychopathological symptoms, and physical health outcomes were assessed with linear and Poisson regression models. Mediation was assessed with difference-in-coefficients method.
   Results: In the fully-adjusted models, CM was associated with higher levels of anxiety and depression, psychological distress, difficulty in sleeping, insomnia, and use of sleeping pills and antidepressants in adulthood (p < 0.05). Moreover, CM was associated with a more than two-folds increased risk of consultation with psychiatrist (p < 0.001), a 26% increased risk of forgetfulness (p < 0.001), a 15% increased risk of decline in memory (p < 0.001), and a 96% increased risk of psychiatric problems (p < 0.001) over the course of life. In the fully-adjusted models, CM was associated with a 27-82% increased risk of physical health outcomes in adulthood (p < 0.05). Indicators of psychopathological symptoms significantly (p < 0.05) mediate the associations between CM and physical health outcomes.
   Limitations: The design of this study is cross-sectional, and all measures are self-reported.
   Conclusion: The associations between retrospectively-reported CM and physical health outcomes in adulthood are partially driven by psychopathological symptoms in adulthood.
C1 [Sheikh, Mashhood Ahmed] Univ Tromso, Dept Community Med, N-9037 Tromso, Norway.
C3 UiT The Arctic University of Tromso
RP Sheikh, MA (corresponding author), Univ Tromso, Dept Community Med, N-9037 Tromso, Norway.
EM mashhood.a.sheikh@uit.no
RI Sheikh, Mashhood Ahmed/D-8599-2018
OI Sheikh, Mashhood Ahmed/0000-0002-3212-592X
CR Anda R. F., 2006, EUR ARCH PSYCHIAT CL, V256
   [Anonymous], 2011, BMJ
   Baumeister D, 2016, MOL PSYCHIATR, V21, P642, DOI 10.1038/mp.2015.67
   Baumeister D, 2014, SOC PSYCH PSYCH EPID, V49, P841, DOI 10.1007/s00127-014-0887-z
   Blanchette CM, 2008, ANN EPIDEMIOL, V18, P316, DOI 10.1016/j.annepidem.2007.11.004
   Cerdá M, 2012, DEPRESS ANXIETY, V29, P359, DOI 10.1002/da.21947
   Cigolle C. T., 2016, J GERONTOL B-PSYCHOL
   Coates D, 2010, AUST SOC WORK, V63, P391, DOI 10.1080/0312407X.2010.508533
   Coccaro EF, 2014, JAMA PSYCHIAT, V71, P158, DOI 10.1001/jamapsychiatry.2013.3297
   Coelho R, 2014, ACTA PSYCHIAT SCAND, V129, P180, DOI 10.1111/acps.12217
   Cohen HW, 2000, AM J MED, V108, P2, DOI 10.1016/S0002-9343(99)00301-0
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   Correll CU, 2015, WORLD PSYCHIATRY, V14, P119, DOI 10.1002/wps.20204
   Danese A, 2012, PHYSIOL BEHAV, V106, P29, DOI 10.1016/j.physbeh.2011.08.019
   De Bellis MD, 2014, CHILD ADOL PSYCH CL, V23, P185, DOI 10.1016/j.chc.2014.01.002
   Dortland AKBV, 2010, ACTA PSYCHIAT SCAND, V122, P30, DOI 10.1111/j.1600-0447.2010.01565.x
   Duncan AE, 2015, PREV CHRONIC DIS, V12, DOI 10.5888/pcd12.140434
   Fagundes CP, 2013, BRAIN BEHAV IMMUN, V27, P8, DOI 10.1016/j.bbi.2012.06.014
   Felitti VJ, 1998, AM J PREV MED, V14, P245, DOI 10.1016/S0749-3797(98)00017-8
   Fosgate GT, 2006, EMERG THEMES EPIDEMI, V3, DOI 10.1186/1742-7622-3-7
   Gee DG, 2015, NEUROBIOL STRESS, V1, P184, DOI 10.1016/j.ynstr.2015.02.001
   Heffner KL, 2011, IMMUNOL ALLERGY CLIN, V31, P95, DOI 10.1016/j.iac.2010.09.005
   HELLHAMMER DH, 1993, PSYCHOTHER PSYCHOSOM, V60, P8, DOI 10.1159/000288675
   Hippisley-Cox J, 2001, BRIT MED J, V323, P666, DOI 10.1136/bmj.323.7314.666
   Hostinar CE, 2017, PSYCHONEUROENDOCRINO, V75, P152, DOI 10.1016/j.psyneuen.2016.10.026
   Huang KL, 2017, J PSYCHOPHARMACOL, V31, P1544, DOI 10.1177/0269881117714047
   Jacobsen BK, 2012, INT J EPIDEMIOL, V41, P961, DOI 10.1093/ije/dyr049
   Joung KE, 2014, J CLIN ENDOCR METAB, V99, pE1055, DOI 10.1210/jc.2013-3669
   Kalmakis KA, 2015, J AM ASSOC NURSE PRA, V27, P457, DOI 10.1002/2327-6924.12215
   Kaufman Jay S, 2004, Epidemiol Perspect Innov, V1, P4, DOI 10.1186/1742-5573-1-4
   Kaufman JS, 2009, INT J EPIDEMIOL, V38, P845, DOI 10.1093/ije/dyp163
   Lorton D, 2006, NEUROIMMUNOMODULAT, V13, P357, DOI 10.1159/000104864
   McEwen BS, 2000, NEUROPSYCHOPHARMACOL, V22, P108, DOI 10.1016/S0893-133X(99)00129-3
   Mock SE, 2011, FRONT PSYCHOL, V2, DOI 10.3389/fpsyg.2010.00246
   Naimi AI, 2014, INT J EPIDEMIOL, V43, P1656, DOI 10.1093/ije/dyu107
   Nusslock R, 2016, BIOL PSYCHIAT, V80, P23, DOI 10.1016/j.biopsych.2015.05.017
   Pan A, 2010, ARCH INTERN MED, V170, P1884, DOI 10.1001/archinternmed.2010.356
   Plaza A, 2012, PSYCHIAT RES, V200, P329, DOI 10.1016/j.psychres.2012.06.032
   Post RM, 2013, J AFFECT DISORDERS, V147, P288, DOI 10.1016/j.jad.2012.11.020
   Procaccini C, 2014, FRONT IMMUNOL, V5, DOI 10.3389/fimmu.2014.00143
   Rich-Edwards JW, 2010, AM J PREV MED, V39, P529, DOI 10.1016/j.amepre.2010.09.007
   Rubin RR, 2008, DIABETES CARE, V31, P420, DOI 10.2337/dc07-1827
   Scott KM, 2011, ARCH GEN PSYCHIAT, V68, P838, DOI 10.1001/archgenpsychiatry.2011.77
   Sheikh MA, 2018, J PSYCHIATR RES, V103, P173, DOI 10.1016/j.jpsychires.2018.05.027
   Sheikh MA, 2018, EUR CHILD ADOLES PSY, V27, P481, DOI 10.1007/s00787-017-1090-z
   Sheikh MA, 2018, J PSYCHOSOM RES, V108, P78, DOI 10.1016/j.jpsychores.2018.03.001
   Sheikh MA, 2018, J PSYCHIATR RES, V101, P50, DOI 10.1016/j.jpsychires.2018.02.025
   Sheikh MA, 2018, INT J PUBLIC HEALTH, V63, P181, DOI 10.1007/s00038-017-1021-2
   Sheikh MA, 2018, J AFFECT DISORDERS, V229, P206, DOI 10.1016/j.jad.2017.12.051
   Sheikh MA, 2018, J AFFECT DISORDERS, V226, P21, DOI 10.1016/j.jad.2017.09.015
   Sheikh MA, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-164
   Shields ME, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-3491-1
   Slavich GM, 2010, NEUROSCI BIOBEHAV R, V35, P39, DOI 10.1016/j.neubiorev.2010.01.003
   Smith Sean M, 2006, Dialogues Clin Neurosci, V8, P383
   Springer KW, 2003, J GEN INTERN MED, V18, P864, DOI 10.1046/j.1525-1497.2003.20918.x
   Tata LJ, 2005, HEART, V91, P465, DOI 10.1136/hrt.2004.037457
   Teicher MH, 2013, AM J PSYCHIAT, V170, P1114, DOI 10.1176/appi.ajp.2013.12070957
   Teicher MH, 2002, PSYCHIAT CLIN N AM, V25, P397, DOI 10.1016/S0193-953X(01)00003-X
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vogelzangs N, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.27
   Weis JosephG., 1989, FAMILY VIOLENCE, P117, DOI DOI 10.1086/449153
   Yang YC, 2017, BIODEMOGR SOC BIOL, V63, P87, DOI 10.1080/19485565.2017.1279536
   Yoon JM, 2013, KOREAN J FAM MED, V34, P228, DOI 10.4082/kjfm.2013.34.4.228
NR 63
TC 11
Z9 14
U1 0
U2 116
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD DEC 1
PY 2018
VL 241
BP 80
EP 85
DI 10.1016/j.jad.2018.07.085
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA GS6OK
UT WOS:000443816800011
PM 30099267
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Liu, HY
   Wang, GQ
   Zhao, J
   Hu, J
   Mu, YM
   Gu, WJ
AF Liu, Hongyan
   Wang, Guoqi
   Zhao, Jian
   Hu, Jia
   Mu, Yiming
   Gu, Weijun
TI Association of skin autofluorescence with depressive symptoms and the
   severity of depressive symptoms: The prospective REACTION study
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Advanced glycation end-products(AGEs); Depressive symptom; Skin
   autofluorescence (SAF)
ID GLYCATION END-PRODUCTS; ENDOGENOUS SECRETORY RECEPTOR; METABOLIC
   SYNDROME; RISK; INDIVIDUALS; DURATION; DISEASE; GLUCOSE; STRESS; LEVEL
AB Aim: Millions of people are afflicted by depression, a highly prevalent mental illness with increased morbidity and mortality. Advanced glycation end-products (AGEs) are potential risk factors for depression. We aimed to investigate the correlation of AGEs with depressive symptoms and the severity of depressive symptoms. Methods: This study was nested in the prospective REACTION (Risk Evaluation of cAncers in Chinese diabeTic Individuals) study and included 4420 eligible participants. skin autofluorescence (SAF) was used to measure skin AGEs. Depressive symptoms were evaluated by the Self-Rating Depression Scale (SDS). Multiple logistic regression analysis was used to assess the association of AGEs with depressive symptoms and the severity of depressive symptoms. Results: Logistic analysis showed a significantly positive relationship between quartiles of SAF-AGEs and the risk of depressive symptoms with the OR [95% confidence interval (CI), p value] of 1.24 (95% CI: 1.03-1.50, p = 0.022), 1.39 (95% CI: 1.15-1.68, p = 0.001) and 1.57 (95% CI: 1.28-1.91, p < 0.001) for multivariable-adjusted model respectively. And SAF-AGEs were associated with the severity of depressive symptoms with the multivariable-adjusted OR (95% CI, p value) of 1.06 (95% CI:0.79-1.43, p = 0.681), 1.47 (95% CI: 1.08-1.99, p = 0.014), and 1.54 (95% CI: 1.12-2.11, p = 0.008) respectively. Stratified analyses showed that SAF-AGEs were significantly associated with the severity of depressive symptoms only in females, overweight people, individuals with hypertension, and those without diabetes and insomnia. Conclusions: The present study showed that a higher SAF-AGEs level was associated with depressive symptoms and the severity of depressive symptoms.
C1 [Liu, Hongyan; Zhao, Jian; Hu, Jia; Mu, Yiming; Gu, Weijun] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Endocrinol, Beijing 100853, Peoples R China.
   [Wang, Guoqi] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Pediat, Beijing 100853, Peoples R China.
   [Mu, Yiming; Gu, Weijun] 28 Fuxing Rd, Beijing 100853, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Chinese People's
   Liberation Army General Hospital
RP Mu, YM; Gu, WJ (corresponding author), 28 Fuxing Rd, Beijing 100853, Peoples R China.
EM muyiming@301hospital.com; guweijun301@163.com
RI Jian, Zhao/AAJ-8262-2021
FU Beijing Science and Technology Commission of China [Z201100005520014]
FX This study was supported by the Beijing Science and Technology
   Commission of China (project number Z201100005520014) .
CR Ahmad S, 2023, J ETHNOPHARMACOL, V305, DOI 10.1016/j.jep.2022.116117
   Akhter F, 2020, J ALZHEIMERS DIS, V76, P165, DOI 10.3233/JAD-191236
   Anderson G, 2013, PHARMACOL REP, V65, P1647, DOI 10.1016/S1734-1140(13)71526-3
   Basta G, 2008, ATHEROSCLEROSIS, V196, P9, DOI 10.1016/j.atherosclerosis.2007.07.025
   Baune BT, 2010, BIOL PSYCHIAT, V67, P543, DOI 10.1016/j.biopsych.2009.11.004
   Binder EB, 2004, NAT GENET, V36, P1319, DOI 10.1038/ng1479
   Boyer F, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/534873
   Chen G, 2012, DIABETES TECHNOL THE, V14, P936, DOI 10.1089/dia.2012.0072
   Chen K, 2022, BMC HEALTH SERV RES, V22, DOI 10.1186/s12913-022-07912-8
   Conway BN, 2012, DIABETES CARE, V35, P2331, DOI 10.2337/dc12-0053
   Debnath M, 2021, PROG NEURO-PSYCHOPH, V111, DOI 10.1016/j.pnpbp.2021.110343
   Duman RS, 2006, BIOL PSYCHIAT, V59, P1116, DOI 10.1016/j.biopsych.2006.02.013
   Eriksson MD, 2021, J PSYCHOSOM RES, V145, DOI 10.1016/j.jpsychores.2021.110488
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   Fabricatore AN, 2011, INT J OBESITY, V35, P1363, DOI 10.1038/ijo.2011.2
   Garabiles MR, 2023, INT J BEHAV MED, V30, P234, DOI 10.1007/s12529-022-10087-5
   Grabez M, 2022, REV CARDIOVASC MED, V23, DOI 10.31083/j.rcm2302057
   Gryszczynska B., 2019, INT J MOL SCI, P20
   Hagen JM, 2020, J AFFECT DISORDERS, V275, P230, DOI 10.1016/j.jad.2020.06.040
   Heath L, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0263228
   Hidese S, 2021, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.594394
   Hirshkowitz M, 2015, SLEEP HEALTH, V1, P40, DOI 10.1016/j.sleh.2014.12.010
   Huan L., 2022, International Journal of Environmental Research and Public Health, V19
   Huang QF, 2022, HYPERTENS RES, V45, P665, DOI 10.1038/s41440-021-00805-z
   Kaneez M, 2021, CUREUS J MED SCIENCE, V13, DOI 10.7759/cureus.13477
   Kuzan A, 2021, BIOMED REP, V14, DOI 10.3892/br.2021.1422
   Li B., 2023, HYPERTENS RES OFF J
   Li YQ, 2023, CRIT REV FOOD SCI, V63, P9816, DOI 10.1080/10408398.2022.2076064
   Lin Y, 2021, DIABET METAB SYND OB, V14, P4811, DOI 10.2147/DMSO.S338915
   Ljubicic M, 2020, PSYCHONEUROENDOCRINO, V117, DOI 10.1016/j.psyneuen.2020.104709
   Luo D, 2022, BMC PSYCHIATRY, V22, DOI 10.1186/s12888-022-03933-z
   Mahmood A, 2021, EUR HEART J, V42, P4169, DOI 10.1093/eurheartj/ehab500
   Malynn S, 2013, NEUROCHEM RES, V38, P694, DOI 10.1007/s11064-012-0967-y
   Meerwaldt R, 2004, DIABETOLOGIA, V47, P1324, DOI 10.1007/s00125-004-1451-2
   Meerwaldt R., 2005, J AM SOC
   Messier C, 2005, NEUROBIOL AGING, V26, pS26, DOI 10.1016/j.neurobiolaging.2005.09.014
   Milaneschi Y, 2019, MOL PSYCHIATR, V24, P18, DOI 10.1038/s41380-018-0017-5
   Monteiro-Fernandes D, 2021, NEUROSCIENCE, V454, P140, DOI 10.1016/j.neuroscience.2020.05.049
   Moutsatsou P, 2014, CLIN CHEM LAB MED, V52, P999, DOI 10.1515/cclm-2013-0978
   Naudé PJW, 2018, WORLD J BIOL PSYCHIA, V19, P461, DOI 10.1080/15622975.2018.1433325
   Ning G, 2012, J DIABETES, V4, P172, DOI 10.1111/j.1753-0407.2012.00182.x
   Nonaka K, 2018, J PERIODONTAL RES, V53, P334, DOI 10.1111/jre.12518
   O'Brien CL, 2024, PSYCHOL HEALTH, V39, P358, DOI 10.1080/08870446.2022.2060507
   Osimo EF, 2020, BRAIN BEHAV IMMUN, V87, P901, DOI 10.1016/j.bbi.2020.02.010
   Pineda EA, 2012, NEUROTHERAPEUTICS, V9, P477, DOI 10.1007/s13311-012-0110-4
   Rao JL, 2017, SCI REP-UK, V7, DOI 10.1038/srep39727
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   Samuels BA, 2016, NEUROSCIENTIST, V22, P26, DOI 10.1177/1073858414561303
   Sasaki N, 1998, AM J PATHOL, V153, P1149, DOI 10.1016/S0002-9440(10)65659-3
   Schmitz N, 2014, DIABETES CARE, V37, P970, DOI 10.2337/dc13-1832
   Singh H., 2022, Mol. (Basel, Switzerland), P27
   Turk Z, 2014, PHYSIOL RES, V63, P199, DOI 10.33549/physiolres.932559
   Twarda-Clapa A., 2022, CHEM CLASSIF RECEPT, V11
   van Dooren FEP, 2017, DEPRESS ANXIETY, V34, P59, DOI 10.1002/da.22527
   Wang YX, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0863-8
   Wium-Andersen IK, 2022, PSYCHONEUROENDOCRINO, V140, DOI 10.1016/j.psyneuen.2022.105715
   Xu YH, 2017, FRONT AGING NEUROSCI, V9, DOI 10.3389/fnagi.2017.00106
   Yaffe K, 2011, NEUROLOGY, V77, P1351, DOI 10.1212/WNL.0b013e3182315a56
   Ying LW, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.696156
   Zaaijer ER, 2015, PSYCHOPHARMACOLOGY, V232, P2597, DOI 10.1007/s00213-015-3891-4
   Zheng Y, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0109765
   Zhu DY, 2022, ACTA PHARMACOL SIN, V43, P2495, DOI 10.1038/s41401-022-00884-9
NR 62
TC 0
Z9 0
U1 0
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD AUG
PY 2023
VL 154
AR 106285
DI 10.1016/j.psyneuen.2023.106285
EA MAY 2023
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA I6FQ2
UT WOS:001003726500001
PM 37148715
OA hybrid
DA 2025-06-11
ER

PT J
AU Kolbe, I
   Dumbell, R
   Oster, H
AF Kolbe, Isa
   Dumbell, Rebecca
   Oster, Henrik
TI Circadian Clocks and the Interaction between Stress Axis and Adipose
   Function
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Review
ID PITUITARY-ADRENAL AXIS; HIGH-FAT DIET; GLUCOCORTICOID REPLACEMENT
   THERAPY; CORTICOTROPIN-RELEASING HORMONE; GENE-EXPRESSION;
   PERIPHERAL-TISSUES; LEPTIN LEVELS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; DIURNAL RHYTHM
AB Many physiological processes and most endocrine functions show fluctuations over the course of the day. These so-called circadian rhythms are governed by an endogenous network of cellular clocks and serve as an adaptation to daily and, thus, predictable changes in the organism's environment. Circadian clocks have been described in several tissues of the stress axis and in adipose cells where they regulate the rhythmic and stimulated release of stress hormones, such as glucocorticoids, and various adipokine factors. Recent work suggests that both adipose and stress axis clock systems reciprocally influence each other and adrenal-adipose rhythms may be key players in the development and therapy of metabolic disorders. In this review, we summarize our current understanding of adrenal and adipose tissue rhythms and clocks and how they might interact to regulate energy homoeostasis and stress responses under physiological conditions. Potential chronotherapeutic strategies for the treatment of metabolic and stress disorders are discussed.
C1 [Kolbe, Isa; Dumbell, Rebecca; Oster, Henrik] Univ Lubeck, Chronophysiol Grp, Dept Med 1, D-23538 Lubeck, Germany.
C3 University of Lubeck
RP Oster, H (corresponding author), Univ Lubeck, Chronophysiol Grp, Dept Med 1, D-23538 Lubeck, Germany.
EM henrik.oster@uksh.de
RI Dumbell, Rebecca/AES-7678-2022; Oster, Henrik/O-4426-2019; Oster,
   Henrik/D-2335-2013
OI Dumbell, Rebecca/0000-0002-8805-3777; Oster, Henrik/0000-0002-1414-7068
FU German Research Foundation (DFG) [GRK1957]
FX This work is supported by a Grant of the German Research Foundation
   (DFG) to Henrik Oster (GRK1957). Henrik Oster is a Lichtenberg Fellow of
   the Volkswagen Foundation.
CR Ahima RS, 1996, NATURE, V382, P250, DOI 10.1038/382250a0
   Ahima RS, 1998, J CLIN INVEST, V101, P1020, DOI 10.1172/JCI1176
   Albrecht Urs, 2013, Handb Exp Pharmacol, P227, DOI 10.1007/978-3-642-25950-0_9
   ANDREWS RV, 1964, COMP BIOCHEM PHYSIOL, V11, P393, DOI 10.1016/0010-406X(64)90006-4
   Asada M, 2011, LAB INVEST, V91, P203, DOI 10.1038/labinvest.2010.170
   Balsalobre A, 2000, SCIENCE, V289, P2344, DOI 10.1126/science.289.5488.2344
   Barclay JL, 2013, AM J PHYSIOL-ENDOC M, V304, pE1053, DOI 10.1152/ajpendo.00512.2012
   Berneis K, 1996, EUR J ENDOCRINOL, V135, P663, DOI 10.1530/eje.0.1350663
   Birketvedt GS, 2002, AM J PHYSIOL-ENDOC M, V282, pE366, DOI 10.1152/ajpendo.00251.2001
   Bittman EL, 2003, AM J PHYSIOL-REG I, V285, pR561, DOI 10.1152/ajpregu.00783.2002
   Boivin DB, 1998, NEUROREPORT, V9, P779, DOI 10.1097/00001756-199803300-00002
   Boivin DB, 2000, J PSYCHIATR NEUROSCI, V25, P446
   Bornstein SR, 2006, MOL PSYCHIATR, V11, P892, DOI 10.1038/sj.mp.4001873
   Bornstein SR, 1997, DIABETES, V46, P1235, DOI 10.2337/diabetes.46.7.1235
   Boston RC, 2008, AM J CLIN NUTR, V87, P1672, DOI 10.1093/ajcn/87.6.1672
   Branth S, 2007, NUTR METAB CARDIOVAS, V17, P427, DOI 10.1016/j.numecd.2006.03.001
   Brown SA, 2012, DEV CELL, V22, P477, DOI 10.1016/j.devcel.2012.02.007
   BUIJS RM, 1993, AM J PHYSIOL, V264, pR1186, DOI 10.1152/ajpregu.1993.264.6.R1186
   Buijs RM, 1999, EUR J NEUROSCI, V11, P1535, DOI 10.1046/j.1460-9568.1999.00575.x
   Burén J, 2007, ENDOCRINOLOGY, V148, P2716, DOI 10.1210/en.2006-0897
   Buttgereit F, 2008, LANCET, V371, P205, DOI 10.1016/S0140-6736(08)60132-4
   Campino C, 2011, HORM METAB RES, V43, P337, DOI 10.1055/s-0031-1271693
   Cano P, 2009, OBESITY, V17, P1866, DOI 10.1038/oby.2009.200
   Cao HM, 2014, J ENDOCRINOL, V220, pT47, DOI 10.1530/JOE-13-0339
   Caprio M, 2007, FASEB J, V21, P2185, DOI 10.1096/fj.06-7970com
   Chu MC, 2006, AM J OBSTET GYNECOL, V194, P100, DOI 10.1016/j.ajog.2005.06.073
   Chung S, 2011, BBA-MOL BASIS DIS, V1812, P581, DOI 10.1016/j.bbadis.2011.02.003
   Considine RV, 1996, NEW ENGL J MED, V334, P292, DOI 10.1056/NEJM199602013340503
   Cook A., 2008, StemBook
   Curtis AM, 2007, P NATL ACAD SCI USA, V104, P3450, DOI 10.1073/pnas.0611680104
   DagogoJack S, 1997, J CLIN ENDOCR METAB, V82, P3230, DOI 10.1210/jc.82.10.3230
   Dallmann R, 2006, J COMP PHYSIOL A, V192, P769, DOI 10.1007/s00359-006-0114-9
   Dallmann R, 2012, P NATL ACAD SCI USA, V109, P2625, DOI 10.1073/pnas.1114410109
   Damiola F, 2000, GENE DEV, V14, P2950, DOI 10.1101/gad.183500
   de Guia RM, 2014, HORM MOL BIOL CLIN I, V19, P117, DOI 10.1515/hmbci-2014-0021
   de Kloet ER, 2005, NAT REV NEUROSCI, V6, P463, DOI 10.1038/nrn1683
   de Oliveira C, 2011, STEROIDS, V76, P1260, DOI 10.1016/j.steroids.2011.06.004
   Degawa-Yamauchi M, 2005, OBES RES, V13, P662, DOI 10.1038/oby.2005.74
   DEVOS P, 1995, J BIOL CHEM, V270, P15958, DOI 10.1074/jbc.270.27.15958
   Dibner C, 2010, ANNU REV PHYSIOL, V72, P517, DOI 10.1146/annurev-physiol-021909-135821
   Dickmeis T, 2013, MOL CELL ENDOCRINOL, V380, P2, DOI 10.1016/j.mce.2013.05.012
   Dimitrov S, 2009, BLOOD, V113, P5134, DOI 10.1182/blood-2008-11-190769
   DIVERTIE GD, 1991, DIABETES, V40, P1228, DOI 10.2337/diabetes.40.10.1228
   Doi M, 2010, NAT MED, V16, P67, DOI 10.1038/nm.2061
   Dudley CA, 2003, SCIENCE, V301, P379, DOI 10.1126/science.1082795
   Engeland William C, 2013, Handb Clin Neurol, V117, P37, DOI 10.1016/B978-0-444-53491-0.00004-3
   ENGLER D, 1990, ENDOCRINOLOGY, V127, P1956, DOI 10.1210/endo-127-4-1956
   Fahrenkrug J, 2008, J NEUROENDOCRINOL, V20, P323, DOI 10.1111/j.1365-2826.2008.01651.x
   Friedman JM, 1998, NATURE, V395, P763, DOI 10.1038/27376
   García-Prieto MD, 2007, CLIN ENDOCRINOL, V66, P185, DOI 10.1111/j.1365-2265.2006.02705.x
   Girotti M, 2009, AM J PHYSIOL-ENDOC M, V296, pE888, DOI 10.1152/ajpendo.90946.2008
   Glasow A, 1998, J CLIN ENDOCR METAB, V83, P4459, DOI 10.1210/jc.83.12.4459
   Gómez-Abellán P, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0050435
   Gremese E, 2014, FRONT IMMUNOL, V5, DOI 10.3389/fimmu.2014.00576
   Griebel G, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00049
   Grimaldi B, 2010, CELL METAB, V12, P509, DOI 10.1016/j.cmet.2010.10.005
   Guan ZW, 2005, BRAIN BEHAV IMMUN, V19, P526, DOI 10.1016/j.bbi.2005.01.005
   Hardie LJ, 1996, HORM METAB RES, V28, P685, DOI 10.1055/s-2007-979878
   Harris HJ, 2001, ENDOCRINOLOGY, V142, P114, DOI 10.1210/en.142.1.114
   Havel PJ, 2002, CURR OPIN LIPIDOL, V13, P51, DOI 10.1097/00041433-200202000-00008
   Heiman ML, 1997, ENDOCRINOLOGY, V138, P3859, DOI 10.1210/en.138.9.3859
   Henley D. E., 2009, Journal of Medical Engineering & Technology, V33, P199, DOI 10.1080/03091900802185970
   Hoppmann J, 2010, J ENDOCRINOL, V204, P153, DOI 10.1677/JOE-09-0292
   Hryhorczuk C, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00177
   Huscher D, 2009, ANN RHEUM DIS, V68, P1119, DOI 10.1136/ard.2008.092163
   Husebye ES, 2014, J INTERN MED, V275, P104, DOI 10.1111/joim.12162
   Iwen KAH, 2008, J ENDOCRINOL, V196, P465, DOI 10.1677/JOE-07-0299
   Johannsson G, 2012, J CLIN ENDOCR METAB, V97, P473, DOI 10.1210/jc.2011-1926
   Johannsson G, 2009, EUR J ENDOCRINOL, V161, P119, DOI 10.1530/EJE-09-0170
   Kargi AY, 2014, INT J ENDOCRINOL, V2014, DOI 10.1155/2014/614074
   Kiess W, 1996, HORM METAB RES, V28, P708, DOI 10.1055/s-2007-979883
   Kiessling S, 2010, J CLIN INVEST, V120, P2600, DOI 10.1172/JCI41192
   Klerman EB, 2002, J BIOL RHYTHM, V17, P181, DOI 10.1177/074873002129002474
   Kohsaka A, 2007, CELL METAB, V6, P414, DOI 10.1016/j.cmet.2007.09.006
   Kolaczynski JW, 1997, J CLIN ENDOCR METAB, V82, P3895, DOI 10.1210/jc.82.11.3895
   Kwon S, 2013, AM J MED SCI, V345, P274, DOI 10.1097/MAJ.0b013e31828a6a01
   Lamia KA, 2011, NATURE, V480, P552, DOI 10.1038/nature10700
   Larsson H, 1996, J CLIN ENDOCR METAB, V81, P4428, DOI 10.1210/jc.81.12.4428
   Le Minh N, 2001, EMBO J, V20, P7128, DOI 10.1093/emboj/20.24.7128
   Lee DK, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms7618
   Lee MJ, 2014, BBA-MOL BASIS DIS, V1842, P473, DOI 10.1016/j.bbadis.2013.05.029
   Leliavski A, 2014, ENDOCRINOLOGY, V155, P133, DOI 10.1210/en.2013-1531
   Lemos DR, 2006, MOL ENDOCRINOL, V20, P1164, DOI 10.1210/me.2005-0361
   Li P, 2009, BIOCHEM BIOPH RES CO, V390, P1208, DOI 10.1016/j.bbrc.2009.10.122
   Lightman SL, 2010, NAT REV NEUROSCI, V11, P710, DOI 10.1038/nrn2914
   Lilley TR, 2012, ENDOCRINOLOGY, V153, P732, DOI 10.1210/en.2011-1624
   Liston C, 2013, NAT NEUROSCI, V16, P698, DOI 10.1038/nn.3387
   Ljung T, 2000, OBES RES, V8, P487, DOI 10.1038/oby.2000.61
   London E, 2014, HORM METAB RES, V46, P897, DOI 10.1055/s-0034-1389956
   Lovås K, 2007, EUR J ENDOCRINOL, V157, P109, DOI 10.1530/EJE-07-0052
   Lovås K, 2009, EUR J ENDOCRINOL, V160, P993, DOI 10.1530/EJE-08-0880
   Lucassen EA, 2012, CURR OBES REP, V1, P208, DOI 10.1007/s13679-012-0028-5
   Lund J, 2001, J ENDOCRINOL, V171, P557, DOI 10.1677/joe.0.1710557
   MARTIN RJ, 1978, HORM METAB RES, V10, P187, DOI 10.1055/s-0028-1093431
   Masuzaki H, 1997, J CLIN ENDOCR METAB, V82, P2542, DOI 10.1210/jc.82.8.2542
   MEIER AH, 1976, ENDOCRINOLOGY, V98, P1475, DOI 10.1210/endo-98-6-1475
   Miell JP, 1996, HORM METAB RES, V28, P704, DOI 10.1055/s-2007-979882
   Minokoshi Y, 2004, NATURE, V428, P569, DOI 10.1038/nature02440
   MOORE RY, 1972, BRAIN RES, V42, P201, DOI 10.1016/0006-8993(72)90054-6
   Muglia LJ, 1997, J CLIN INVEST, V99, P2923, DOI 10.1172/JCI119487
   MURAKAMI T, 1995, BIOCHEM BIOPH RES CO, V214, P1260, DOI 10.1006/bbrc.1995.2422
   Nader N, 2010, TRENDS ENDOCRIN MET, V21, P277, DOI 10.1016/j.tem.2009.12.011
   Nader N, 2009, FASEB J, V23, P1572, DOI 10.1096/fj.08-117697
   Oster H, 2006, GENE EXPR PATTERNS, V6, P400, DOI 10.1016/j.modgep.2005.09.006
   Oster H, 2006, J BIOL RHYTHM, V21, P350, DOI 10.1177/0748730406293053
   Oster H, 2006, CELL METAB, V4, P163, DOI 10.1016/j.cmet.2006.07.002
   OTTENWELLER JE, 1982, ENDOCRINOLOGY, V111, P1334, DOI 10.1210/endo-111-4-1334
   Pan A, 2011, PLOS MED, V8, DOI 10.1371/journal.pmed.1001141
   Panda S, 2002, NATURE, V417, P329, DOI 10.1038/417329a
   PapaspyrouRao S, 1997, J CLIN ENDOCR METAB, V82, P1635, DOI 10.1210/jc.82.5.1635
   Parlee SD, 2010, ENDOCRINOLOGY, V151, P2590, DOI 10.1210/en.2009-0794
   Paschke L, 2010, PEPTIDES, V31, P1715, DOI 10.1016/j.peptides.2010.06.007
   Pasquali R, 2006, ANN NY ACAD SCI, V1083, P111, DOI 10.1196/annals.1367.009
   Pralong FP, 1998, ENDOCRINOLOGY, V139, P4264, DOI 10.1210/en.139.10.4264
   Proença ARG, 2014, BRAZ J MED BIOL RES, V47, P192, DOI 10.1590/1414-431X20132911
   Ramachandran R, 2012, J AM GERIATR SOC, V60, P707, DOI 10.1111/j.1532-5415.2011.03865.x
   Rask E, 2001, J CLIN ENDOCR METAB, V86, P1418, DOI 10.1210/jc.86.3.1418
   Ratman D, 2013, MOL CELL ENDOCRINOL, V380, P41, DOI 10.1016/j.mce.2012.12.014
   REUL JMHM, 1985, ENDOCRINOLOGY, V117, P2505, DOI 10.1210/endo-117-6-2505
   Rey G, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1000595
   Rosmond R, 2005, PSYCHONEUROENDOCRINO, V30, P1, DOI 10.1016/j.psyneuen.2004.05.007
   Rosmond R, 1998, J CLIN ENDOCR METAB, V83, P1853, DOI 10.1210/jc.83.6.1853
   Rossi GP, 2006, INT J MOL MED, V17, P975
   SAITO M, 1983, ENDOCRINOLOGY, V113, P2181, DOI 10.1210/endo-113-6-2181
   Schoeller DA, 1997, J CLIN INVEST, V100, P1882, DOI 10.1172/JCI119717
   Segall LA, 2009, NEUROSCI LETT, V457, P58, DOI 10.1016/j.neulet.2009.03.083
   Shostak A, 2013, ADIPOCYTE, V2, P201, DOI 10.4161/adip.26007
   Silha JV, 2003, EUR J ENDOCRINOL, V149, P331, DOI 10.1530/eje.0.1490331
   Silverman MN, 2010, J RHEUMATOL, V37, P1981, DOI 10.3899/jrheum.100688
   Simon C, 2000, AM J PHYSIOL-ENDOC M, V278, pE413, DOI 10.1152/ajpendo.2000.278.3.E413
   Slieker LJ, 1996, J BIOL CHEM, V271, P5301, DOI 10.1074/jbc.271.10.5301
   So AYL, 2009, P NATL ACAD SCI USA, V106, P17582, DOI 10.1073/pnas.0909733106
   Son GH, 2008, P NATL ACAD SCI USA, V105, P20970, DOI 10.1073/pnas.0806962106
   STEPHAN FK, 1972, P NATL ACAD SCI USA, V69, P1583, DOI 10.1073/pnas.69.6.1583
   STEPHENS TW, 1995, NATURE, V377, P530, DOI 10.1038/377530a0
   Stratmann M, 2006, J BIOL RHYTHM, V21, P494, DOI 10.1177/0748730406293889
   Sukumaran S, 2010, PHYSIOL GENOMICS, V42A, P141, DOI 10.1152/physiolgenomics.00106.2010
   Takekoshi K, 1999, BIOCHEM BIOPH RES CO, V261, P426, DOI 10.1006/bbrc.1999.1025
   Torres-Farfan C, 2009, ENDOCRINOLOGY, V150, P2717, DOI 10.1210/en.2008-1683
   Trayhurn P, 2005, ENDOCRINOLOGY, V146, P1003, DOI 10.1210/en.2004-1597
   Tsang AH, 2014, HORM MOL BIOL CLIN I, V19, P103, DOI 10.1515/hmbci-2014-0020
   Turek FW, 2005, SCIENCE, V308, P1043, DOI 10.1126/science.1108750
   Ulrich-Lai YM, 2006, AM J PHYSIOL-REG I, V290, pR1128, DOI 10.1152/ajpregu.00042.2003
   Ulrich-Lai YM, 2009, NAT REV NEUROSCI, V10, P397, DOI 10.1038/nrn2647
   Valenzuela FJ, 2008, ENDOCRINOLOGY, V149, P1454, DOI 10.1210/en.2007-1518
   van der Spek R, 2012, PROG BRAIN RES, V199, P183, DOI 10.1016/B978-0-444-59427-3.00011-3
   Vgontzas AN, 2005, NEUROIMMUNOMODULAT, V12, P131, DOI 10.1159/000084844
   Wabitsch M, 1996, DIABETES, V45, P1435, DOI 10.2337/diabetes.45.10.1435
   Wagner U, 2008, STRESS, V11, P28, DOI 10.1080/10253890701408822
   Waite EJ, 2012, EUR J NEUROSCI, V36, P3142, DOI 10.1111/j.1460-9568.2012.08213.x
   Walker BR, 2000, J INTERN MED, V247, P198, DOI 10.1046/j.1365-2796.2000.00609.x
   WALKER CD, 1992, ENDOCRINOLOGY, V131, P2629, DOI 10.1210/en.131.6.2629
   Walker JJ, 2012, PLOS BIOL, V10, DOI 10.1371/journal.pbio.1001341
   Watts AG, 2004, ENDOCRINOLOGY, V145, P529, DOI 10.1210/en.2003-0394
   Wauters M, 2000, EUR J ENDOCRINOL, V143, P293, DOI 10.1530/eje.0.1430293
   WICK G, 1993, ENDOCR REV, V14, P539, DOI 10.1210/er.14.5.539
   Widjaja A, 1998, J CLIN ENDOCR METAB, V83, P600, DOI 10.1210/jc.83.2.600
   WOLFE LK, 1966, J CLIN ENDOCR METAB, V26, P1261, DOI 10.1210/jcem-26-11-1261
   Wotus C, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0068793
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yamamoto T, 2005, J BIOL CHEM, V280, P42036, DOI 10.1074/jbc.M509600200
   Yildiz BO, 2004, P NATL ACAD SCI USA, V101, P10434, DOI 10.1073/pnas.0403465101
   Yoder JM, 2014, AM J PHYSIOL-REG I, V306, pR387, DOI 10.1152/ajpregu.00519.2013
   Zakrzewska KE, 1999, DIABETES, V48, P365, DOI 10.2337/diabetes.48.2.365
   Zakrzewska KE, 1997, DIABETES, V46, P717, DOI 10.2337/diabetes.46.4.717
   Zhang EE, 2010, NAT REV MOL CELL BIO, V11, P764, DOI 10.1038/nrm2995
   Zhang P, 2008, J LIPID RES, V49, P1519, DOI 10.1194/jlr.M800061-JLR200
   Zvonic S, 2006, DIABETES, V55, P962, DOI 10.2337/diabetes.55.04.06.db05-0873
NR 168
TC 21
Z9 27
U1 0
U2 13
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2015
VL 2015
AR 693204
DI 10.1155/2015/693204
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CH9MR
UT WOS:000354360200001
PM 26000016
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Shelton, RC
   Falola, M
   Li, L
   Zajecka, J
   Fava, M
   Papakostas, GI
AF Shelton, Richard C.
   Falola, Michael
   Li, Li
   Zajecka, John
   Fava, Maurizio
   Papakostas, George I.
TI The pro-inflammatory profile of depressed patients is (partly) related
   to obesity
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Depression; Inflammation; Cytokine; C-reactive protein; Leptin;
   Adiponectin
ID MAJOR DEPRESSION; TREATMENT RESPONSE; METABOLIC SYNDROME; RISK-FACTOR;
   OLDER MEN; SYMPTOMS; CYTOKINES; STRESS; ADULTS; IL-6
AB Many people with major depressive disorder (MDD) show evidence of systemic inflammation, including elevations in inflammatory factors, but the cause is unclear. The purpose of this analysis was to determine if obesity might contribute to the pro-inflammatory state in MDD patients. Blood was obtained from 135 MDD patients and 50 controls. Serum was extracted and assayed for interleukin (IL) - 1 beta, IL-2, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-17, interferon-gamma (IFN gamma), tumor necrosis factor alpha (TNF alpha), C-reactive protein (CRP), leptin, and adiponectin using single- or multi-plex human immunoassay kits. The primary analysis contrasted IL-6, TNF alpha, and CRP between MDD and control groups with body mass index (BMI) as a covariate. The other analytes were compared in an exploratory fashion. IL-6 (but not TNF alpha or CRP) showed significant differences between MDD and controls even after covarying for BMI. Obese controls and obese MDD groups were significantly higher in IL-6 than both lean groups, but the two obese groups did not differ from each other. In the exploratory analyses, the IL-2 level showed robust and significant differences between MDD and controls even after covarying for BMI. Both lean and obese MDD were higher than lean and obese controls. Adiponectin levels were also lower in the MDD sample than controls. Prior findings of higher IL-6, and CRP in MDD patients may be explained, at least in part, based on obesity. High IL-2, however, was associated with depression and not obesity. The results have significant implications for the understanding of pathophysiology and, potentially treatment of MDD. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Shelton, Richard C.; Falola, Michael; Li, Li] Univ Alabama Birmingham, Dept Psychiat, Birmingham, AL 35294 USA.
   [Zajecka, John] Rush Presbyterian St Lukes Med Ctr, Dept Psychiat, Chicago, IL 60612 USA.
   [Fava, Maurizio; Papakostas, George I.] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA.
   [Fava, Maurizio; Papakostas, George I.] Massachusetts Gen Hosp, CTNI, Boston, MA 02114 USA.
C3 University of Alabama System; University of Alabama Birmingham; Rush
   University; Harvard University; Harvard University Medical Affiliates;
   Massachusetts General Hospital; Harvard University; Harvard University
   Medical Affiliates; Massachusetts General Hospital
RP Shelton, RC (corresponding author), Univ Alabama Birmingham, SC 1060,1720 2nd Ave South, Birmingham, AL 35294 USA.
EM rshelton@uab.edu
RI Li, Li/M-3237-2016; Shelton, Richard/AAC-4137-2022; Fava,
   Maurizio/AAH-3548-2020; Papakostas, George/AAF-7461-2021
OI Shelton, Richard/0000-0002-3806-4208
FU NIH National Center for Research Resources [5UL1RR025777-03,
   5KL2RR025776-03, 5TL1RR025775-03]; Brain & Behavior Research Foundation
   and Pamlab, Inc.
FX Support for the sample collection and analysis was provided by the Brain
   & Behavior Research Foundation and Pamlab, Inc. Funding for the REDCAP
   database was provided by the NIH National Center for Research Resources
   as part of its Clinical and Translational Science Award Program
   (5UL1RR025777-03, 5KL2RR025776-03, 5TL1RR025775-03)
CR Akbaraly TN, 2009, DIABETES CARE, V32, P499, DOI 10.2337/dc08-1358
   Almeida OP, 2009, AM J GERIAT PSYCHIAT, V17, P889, DOI 10.1097/JGP.0b013e3181b047e3
   [Anonymous], 1998, J CLIN PSYCHIAT
   [Anonymous], PSYCHOL MED     1020
   Basterzi AD, 2005, HUM PSYCHOPHARM CLIN, V20, P473, DOI 10.1002/hup.717
   Benson S, 2008, BRAIN BEHAV IMMUN, V22, P177, DOI 10.1016/j.bbi.2007.07.003
   Bierhaus A, 2003, P NATL ACAD SCI USA, V100, P1920, DOI 10.1073/pnas.0438019100
   Danese A, 2008, ARCH GEN PSYCHIAT, V65, P409, DOI 10.1001/archpsyc.65.4.409
   Danese A, 2009, ARCH PEDIAT ADOL MED, V163, P1135, DOI 10.1001/archpediatrics.2009.214
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Eller T, 2008, PROG NEURO-PSYCHOPH, V32, P445, DOI 10.1016/j.pnpbp.2007.09.015
   Erermis S, 2004, PEDIATR INT, V46, P296, DOI 10.1111/j.1442-200x.2004.01882.x
   Everson-Rose SA, 2009, PSYCHOSOM MED, V71, P410, DOI 10.1097/PSY.0b013e3181a20c9c
   Fabricatore AN, 2011, INT J OBESITY, V35, P1363, DOI 10.1038/ijo.2011.2
   First MB., 2002, STRUCTURED CLIN INTE
   Gárate I, 2013, BIOL PSYCHIAT, V73, P32, DOI 10.1016/j.biopsych.2012.07.005
   Goodman E, 2002, PEDIATRICS, V110, P497, DOI 10.1542/peds.110.3.497
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Harris PA, 2009, J BIOMED INFORM, V42, P377, DOI 10.1016/j.jbi.2008.08.010
   Herbst S, 2007, PSYCHOSOM MED, V69, P729, DOI 10.1097/PSY.0b013e3181574977
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Hryhorczuk C, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00177
   Jozuka H, 2003, J INT MED RES, V31, P36, DOI 10.1177/147323000303100106
   Kloiber S, 2007, BIOL PSYCHIAT, V62, P321, DOI 10.1016/j.biopsych.2006.10.001
   Lanquillon S, 2000, NEUROPSYCHOPHARMACOL, V22, P370, DOI 10.1016/S0893-133X(99)00134-7
   Maes M, 1997, CYTOKINE, V9, P853, DOI 10.1006/cyto.1997.0238
   MAES M, 1995, J AFFECT DISORDERS, V34, P301, DOI 10.1016/0165-0327(95)00028-L
   MAES M, 1994, PSYCHIAT RES, V54, P143, DOI 10.1016/0165-1781(94)90003-5
   MAES M, 1993, AM J PSYCHIAT, V150, P1189
   Milaneschi Y, 2012, J CLIN PSYCHIAT
   Miller AH, 2009, BIOL PSYCHIAT, V65, P732, DOI 10.1016/j.biopsych.2008.11.029
   Miller GE, 2002, AM J CARDIOL, V90, P1279, DOI 10.1016/S0002-9149(02)02863-1
   Molyneaux E, 2014, OBSTET GYNECOL, V123, P857, DOI 10.1097/AOG.0000000000000170
   MONTGOMERY SA, 1979, BRIT J PSYCHIAT, V134, P382, DOI 10.1192/bjp.134.4.382
   NCHS, 2007, NAT HLTH NUTR EX PRO
   Oskooilar N, 2009, J CLIN PSYCHIAT, V70, P1609, DOI 10.4088/JCP.09l05226blu
   Pace TWW, 2006, AM J PSYCHIAT, V163, P1630, DOI 10.1176/appi.ajp.163.9.1630
   Papakostas GI, 2012, AM J PSYCHIAT, V169, P1267, DOI 10.1176/appi.ajp.2012.11071114
   Papakostas GI, 2005, INT J NEUROPSYCHOPH, V8, P59, DOI 10.1017/S1461145704004602
   Raison CL, 2006, TRENDS IMMUNOL, V27, P24, DOI 10.1016/j.it.2005.11.006
   Roberts RE, 2003, INT J OBESITY, V27, P514, DOI 10.1038/sj.ijo.0802204
   Rotella F, 2013, J CLIN PSYCHIAT, V74, P32, DOI 10.4088/JCP.12r07922
   Schmidt FM, 2014, J PSYCHIATR RES, V55, P29, DOI 10.1016/j.jpsychires.2014.04.021
   Sheehan DV, 1998, J CLIN PSYCHIAT, V59, P22, DOI 10.4088/JCP.09m05305whi
   Shelton RC, 2010, PROG NEUROBIOL, V91, P275, DOI 10.1016/j.pneurobio.2010.04.004
   Simon GE, 2008, GEN HOSP PSYCHIAT, V30, P32, DOI 10.1016/j.genhosppsych.2007.09.001
   Sutherland JP, 2004, METAB SYNDR RELAT D, V2, P82, DOI 10.1089/met.2004.2.82
   TAMHANE AC, 1977, COMMUN STAT A-THEOR, V6, P15, DOI 10.1080/03610927708827466
   Thomas C, 2008, PEDIATRICS, V121, pE1240, DOI 10.1542/peds.2007-2403
   Trivedi MH, 2011, J CLIN PSYCHIAT, V72, P677, DOI 10.4088/JCP.10m06743
   Tuck MK, 2009, J PROTEOME RES, V8, P113, DOI 10.1021/pr800545q
   Vogelzangs N, 2014, NEUROPSYCHOPHARMACOL, V39, P1624, DOI 10.1038/npp.2014.9
   Vogelzangs N, 2010, J CLIN PSYCHIAT, V71, P391, DOI 10.4088/JCP.08m04743blu
   Vogelzangs N, 2008, ARCH GEN PSYCHIAT, V65, P1386, DOI 10.1001/archpsyc.65.12.1386
   Wajchenberg BL, 2000, ENDOCR REV, V21, P697, DOI 10.1210/er.21.6.697
NR 55
TC 50
Z9 52
U1 0
U2 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD NOV
PY 2015
VL 70
BP 91
EP 97
DI 10.1016/j.jpsychires.2015.09.001
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CU8XG
UT WOS:000363826800011
PM 26424427
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chandradasa, M
   Champika, L
   de Silva, S
   Kuruppuarachchi, KALA
AF Chandradasa, Miyuru
   Champika, Layani
   de Silva, Silumini
   Kuruppuarachchi, K. A. L. A.
TI Topiramate's effectiveness on weight reduction in overweight/obese
   persons with schizophrenia: study protocol for a randomized controlled
   trial
SO TRIALS
LA English
DT Article
DE Schizophrenia; Antipsychotic agents; Weight loss; Body weight;
   Anticonvulsants; Randomized trial; Protocol; Sri Lanka; Asia
ID METABOLIC SYNDROME; DOUBLE-BLIND; METAANALYSIS; PREVALENCE; DISORDERS;
   MORTALITY; EFFICACY; SAFETY
AB Background: Schizophrenia is a psychiatric disorder with a higher mortality than that of the general population. Most of the deaths are due to cardiovascular causes and are related to metabolic risks. This risk is due not only to antipsychotics but also to inherent factors of the disorder. Studies in the West have shown topiramate to be effective in schizophrenia to reduce weight gain and for symptomatic control. Whether this is effective for South Asians is not known. It is important because South Asians have a higher risk of metabolic syndrome. We aim to conduct a double-blind, randomized controlled trial comparing topiramate add-on therapy with treatment as usual with antipsychotics in patients with schizophrenia in an outpatient setting in Sri Lanka.
   Methods/design: Ninety patients with schizophrenia presenting to the Colombo North Teaching Hospital will be randomized to intervention and control groups equally using permuted block randomization. Patients with comorbid metabolic disorders and taking prescribed weight-controlling medications will be excluded. The intervention group will be prescribed topiramate in addition to their antipsychotics in a predefined dosing regimen targeting a dose of 100 mg per day. The control subjects are to receive a placebo. As the primary outcome, anthropometric measurements including weight, waist circumference, skinfold thickness, and body mass index will be recorded at baseline and monthly during the study period of 3 months. The secondary outcome is the change in symptoms according to the clinician-administered Brief Psychiatric Rating Scale. Assessment of capacity will be performed and informed consent obtained from all subjects. Ethics approval has been obtained from the ethical review committee of the Faculty of Medicine, University of Kelaniya, and the trial has been registered in the Sri Lanka Clinical Trials Registry.
   Discussion: In this double-blind, randomized controlled trial, we will attempt to assess the effectiveness of topiramate as an add-on therapy compared with treatment as usual for weight control in patients with schizophrenia. To our knowledge, this is the first such study in South Asia, where metabolic risks are found to be higher than in the West and could have unique ethnic factors related to weight gain in schizophrenia.
C1 [Chandradasa, Miyuru; Kuruppuarachchi, K. A. L. A.] Univ Kelaniya, Dept Psychiat, Fac Med, Kelaniya, Sri Lanka.
   [Chandradasa, Miyuru; Champika, Layani; de Silva, Silumini; Kuruppuarachchi, K. A. L. A.] Colombo North Teaching Hosp, Ragama, Sri Lanka.
C3 University Kelaniya; University of Colombo; Colombo North Teaching
   Hospital
RP Chandradasa, M (corresponding author), Univ Kelaniya, Dept Psychiat, Fac Med, Kelaniya, Sri Lanka.; Chandradasa, M (corresponding author), Colombo North Teaching Hosp, Ragama, Sri Lanka.
EM miyuruc@kln.ac.lk
RI De Berardis, Domenico/F-9343-2018; De Silva, Silumini/HMV-9858-2023;
   Chandradasa, Miyuru/R-2045-2016
OI Kuruppuarachchi, Lalith/0000-0002-8380-2329; Rathnayake,
   Layani/0000-0003-0536-9272; Chandradasa, Miyuru/0000-0002-1873-8228
CR Afshar H, 2009, J PSYCHOPHARMACOL, V23, P157, DOI 10.1177/0269881108089816
   [Anonymous], PSYCHIATRIST
   [Anonymous], 1995, WHO Expert Committee on Physical Status: The Use and Interpretation of Anthropometry
   [Anonymous], 1992, The ICD-10 classification of mental and behavioural disorders: Clinical descriptions and diagnostic guidelines
   Chan AW, 2013, ANN INTERN MED, V158, P200, DOI 10.7326/0003-4819-158-3-201302050-00583
   Chandradasa M., 2016, J POSTGRAD I MED, V3, P33, DOI [10.4038/jpgim.8112, DOI 10.4038/JPGIM.8112]
   Chandradasa M, 2016, SRI LANKA J PSYCHIAT, V7, P23
   Chandradasa Miyuru, 2017, BJPsych Int, V14, P36
   Correll CU, 2016, J CLIN PSYCHIAT, V77, pE746, DOI 10.4088/JCP.15r10373
   Crump C, 2013, AM J PSYCHIAT, V170, P324, DOI 10.1176/appi.ajp.2012.12050599
   Darcin AE, 2015, SCHIZOPHR RES, V166, P201, DOI 10.1016/j.schres.2015.05.004
   Edrisinghe N, 2014, Sri Lanka Journal of Psychiatry, V5, P19, DOI [10.4038/sljpsyc.v5i2.7816, DOI 10.4038/SLJPSYC.V5I2.7816]
   Frackiewicz EJ, 1997, ANN PHARMACOTHER, V31, P1360, DOI 10.1177/106002809703101114
   Hahn Margaret K, 2013, Clin Schizophr Relat Psychoses, V6, P186, DOI 10.3371/CSRP.HACO.01062013
   Hapangama A, 2013, CEYLON MED J, V58, P111, DOI 10.4038/cmj.v58i3.6103
   Howes O, 2015, J PSYCHOPHARMACOL, V29, P97, DOI 10.1177/0269881114563634
   Jayathilake IS, 2007, 27 ANN AC SESS POSTG, P21
   KAY SR, 1987, SCHIZOPHRENIA BULL, V13, P261, DOI 10.1093/schbul/13.2.261
   Kim HY, 2014, CLIN PSYCHOPHARM NEU, V12, P128, DOI 10.9758/cpn.2014.12.2.128
   Kuruppuarachchi KALA, 2003, BRIT J PSYCHIAT, V182, P455, DOI 10.1192/bjp.182.5.455-a
   Laursen TM, 2014, ANNU REV CLIN PSYCHO, V10, P425, DOI 10.1146/annurev-clinpsy-032813-153657
   Letmaier M, 2001, INT CLIN PSYCHOPHARM, V16, P295, DOI 10.1097/00004850-200109000-00008
   Misra Anoop, 2014, Nestle Nutr Inst Workshop Ser, V78, P133, DOI 10.1159/000354952
   Narula PK, 2010, SCHIZOPHR RES, V118, P218, DOI 10.1016/j.schres.2010.02.001
   OVERALL JE, 1988, PSYCHOPHARMACOL BULL, V24, P97
   Ranasinghe P, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4041-1
   Riordan HJ, 2011, AM HEALTH DRUG BENEF, V4, P292
   Roberts GMP, 2005, EPILEPSY BEHAV, V6, P366, DOI 10.1016/j.yebeh.2005.01.005
   Sri Lanka Medical Association, SRI LANK CLIN TRIALS
   Vancampfort D, 2012, ACTA PSYCHIAT SCAND, V125, P352, DOI 10.1111/j.1600-0447.2011.01814.x
   Verrotti A, 2011, EPILEPSY RES, V95, P189, DOI 10.1016/j.eplepsyres.2011.05.014
   Zaghdoudi Lilia, 2009, Tunis Med, V87, P593
   Zheng W, 2016, ACTA PSYCHIAT SCAND, V134, P385, DOI 10.1111/acps.12631
NR 33
TC 3
Z9 4
U1 0
U2 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1745-6215
J9 TRIALS
JI Trials
PD SEP 20
PY 2017
VL 18
AR 435
DI 10.1186/s13063-017-2162-6
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA FH7HJ
UT WOS:000411355400002
PM 28931411
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Higashibata, T
   Wakai, K
   Okada, R
   Nakagawa, H
   Hamajima, N
AF Higashibata, Takahiro
   Wakai, Kenji
   Okada, Rieko
   Nakagawa, Hiroko
   Hamajima, Nobuyuki
TI Associations of smoking status with other lifestyle behaviors are
   modified by sex and occupational category among urban civil servants in
   Japan
SO ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
LA English
DT Article
DE Employee; Food habits; Health behavior; Lifestyle; Smoking
ID COLLABORATIVE COHORT JACC; POPULATION-BASED COHORT; LARGE-SCALE COHORT;
   CIGARETTE-SMOKING; MENTAL-HEALTH; ALCOHOL-CONSUMPTION; SLEEP
   ARCHITECTURE; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; POOLED ANALYSIS
AB The aim of the present study was to examine the associations of current smoking with five other unhealthy lifestyle behaviors among urban civil servants in Japan according to sex and occupational category.
   The study included 10,232 urban civil servants in Japan who presented for a health check-up in 2011. We analyzed data on anthropometric measurements and self-reported lifestyle factors.
   Current smokers had a higher BMI than never smokers in white-collar workers, but not in blue-collar workers of both sexes. There were strong associations of current smoking with irregular breakfasting regardless of sex and occupational category. In males, current smokers were less likely to take exercise than ex-smokers in both occupational categories.
   The associations of current smoking with other unhealthy behaviors were modified by sex and occupational category. These results are useful for understanding the health risks among smokers according to sex and occupational category.
C1 [Higashibata, Takahiro; Wakai, Kenji; Okada, Rieko; Nakagawa, Hiroko] Nagoya Univ, Grad Sch Med, Dept Prevent Med, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan.
   [Nakagawa, Hiroko] Aichi Canc Ctr, Res Inst, Div Epidemiol & Prevent, Nagoya, Aichi, Japan.
   [Hamajima, Nobuyuki] Nagoya Univ, Grad Sch Med, Dept Healthcare Adm, Nagoya, Aichi, Japan.
C3 Nagoya University; Aichi Cancer Center; Nagoya University
RP Higashibata, T (corresponding author), Nagoya Univ, Grad Sch Med, Dept Prevent Med, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan.
EM hgsbata@gmail.com
RI Wakai, Kenji/I-7248-2014; Hamajima, Nobuyuki/I-7237-2014; Okada,
   Rieko/M-4989-2014
OI Okada, Rieko/0000-0002-6206-2501
CR Akamatsu R, 2005, AM J HEALTH PROMOT, V19, P406, DOI 10.4278/0890-1171-19.6.406
   Chin DL, 2012, AM J IND MED, V55, P429, DOI 10.1002/ajim.22031
   Chinn S, 2005, LANCET, V365, P1629, DOI 10.1016/S0140-6736(05)66511-7
   Denton M, 2004, SOC SCI MED, V58, P2585, DOI 10.1016/j.socscimed.2003.09.008
   EZOE S, 1994, PREV MED, V23, P98, DOI 10.1006/pmed.1994.1014
   Fukuda Y, 2005, BMC PUBLIC HEALTH, V5, DOI 10.1186/1471-2458-5-53
   Fukuda Y, 2005, ANN EPIDEMIOL, V15, P365, DOI 10.1016/j.annepidem.2004.09.003
   Fukuda Y, 2007, J EPIDEMIOL, V17, P93, DOI 10.2188/jea.17.93
   Hale L, 2005, J PUBLIC HEALTH-UK, V27, P205, DOI 10.1093/pubmed/fdi004
   Ham DC, 2011, J OCCUP ENVIRON MED, V53, P1337, DOI 10.1097/JOM.0b013e3182337778
   Hart CL, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-789
   Hirokawa K, 2009, SOC SCI MED, V68, P1091, DOI 10.1016/j.socscimed.2008.12.040
   Hu LZ, 2007, J OCCUP HEALTH, V49, P443, DOI 10.1539/joh.49.443
   Inoue M, 2010, PUBLIC HEALTH, V124, P530, DOI 10.1016/j.puhe.2010.04.009
   Inoue M, 2012, J EPIDEMIOL COMMUN H, V66, P448, DOI 10.1136/jech.2010.121830
   Iso H, 2007, ASIAN PAC J CANCER P, V8, P35
   Jaehne A, 2012, SLEEP MED, V13, P1286, DOI 10.1016/j.sleep.2012.06.026
   Kaetsu Akihiko, 2002, J Epidemiol, V12, P199
   Kamon Y, 2008, J OCCUP HEALTH, V50, P348, DOI 10.1539/joh.L7158
   Katanoda K, 2008, J EPIDEMIOL, V18, P251, DOI 10.2188/jea.JE2007429
   Krueger PM, 2009, AM J EPIDEMIOL, V169, P1052, DOI 10.1093/aje/kwp023
   Lallukka T, 2008, SOC SCI MED, V66, P1681, DOI 10.1016/j.socscimed.2007.12.027
   Larsson A, 2004, NEUROSCI BIOBEHAV R, V27, P713, DOI 10.1016/j.neubiorev.2003.11.010
   Luo JH, 2007, CANCER CAUSE CONTROL, V18, P603, DOI 10.1007/s10552-007-9002-z
   Mino Y, 2001, PREV MED, V32, P371, DOI 10.1006/pmed.2000.0803
   Nagaya T, 2007, NICOTINE TOB RES, V9, P1027, DOI 10.1080/14622200701591575
   Nakamura S, 2000, OCCUP MED-OXFORD, V50, P11, DOI 10.1093/occmed/50.1.11
   Nakashita Y, 2010, J EPIDEMIOL, V20, P391, DOI 10.2188/jea.JE20100043
   Nakayama K, 1997, Environ Health Prev Med, V2, P11, DOI 10.1007/BF02931223
   Nishi N, 2004, SOC SCI MED, V58, P1159, DOI 10.1016/S0277-9536(03)00287-9
   Nishino Y, 2006, J EPIDEMIOL, V16, P49, DOI 10.2188/jea.16.49
   Nishiyama M, 2009, TOHOKU J EXP MED, V218, P259, DOI 10.1620/tjem.218.259
   Ohida Takashi, 2001, Keio Journal of Medicine, V50, P263
   Redline S, 2004, ARCH INTERN MED, V164, P406, DOI 10.1001/archinte.164.4.406
   Roberts V, 2012, PSYCHOPHARMACOLOGY, V222, P1, DOI 10.1007/s00213-012-2731-z
   Sundström J, 2006, BMJ-BRIT MED J, V332, P878, DOI 10.1136/bmj.38766.624097.1F
   Suzuki E, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-489
   Tamakoshi A, 2010, J EPIDEMIOL, V20, P370, DOI 10.2188/jea.JE20100017
   Zhang L, 2006, AM J EPIDEMIOL, V164, P529, DOI 10.1093/aje/kwj231
NR 39
TC 4
Z9 4
U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1342-078X
EI 1347-4715
J9 ENVIRON HEALTH PREV
JI Environ. Health Prev.
PD NOV
PY 2016
VL 21
IS 6
BP 539
EP 546
DI 10.1007/s12199-016-0577-4
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA EC4OO
UT WOS:000388112700018
PM 27699695
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Friedman, EM
   Montez, JK
   Sheehan, CM
   Guenewald, TL
   Seeman, TE
AF Friedman, Esther M.
   Montez, Jennifer Karas
   Sheehan, Connor McDevitt
   Guenewald, Tara L.
   Seeman, Teresa E.
TI Childhood Adversities and Adult Cardiometabolic Health: Does the
   Quantity, Timing, and Type of Adversity Matter?
SO JOURNAL OF AGING AND HEALTH
LA English
DT Article
DE life course; childhood; midlife; gender; obesity; heart disease;
   diabetes
ID EARLY-LIFE ADVERSITY; SOCIOECONOMIC-STATUS; CHRONIC-DISEASE;
   MENTAL-HEALTH; EDUCATIONAL-ATTAINMENT; RETROSPECTIVE REPORTS;
   CARDIOVASCULAR RISK; METABOLIC SYNDROME; PERSONAL CONTROL; EXPERIENCES
AB Objective: Adverse events in childhood can indelibly influence adult health. While evidence for this association has mounted, a fundamental set of questions about how to operationalize adverse events has been understudied. Method: We used data from the National Survey of Midlife Development in the United States to examine how quantity, timing, and types of adverse events in childhood are associated with adult cardiometabolic health. Results: The best-fitting specification of quantity of events was a linear measure reflecting a dose-response relationship. Timing of event mattered less than repeated exposure to events. Regarding the type of event, academic interruptions and sexual/physical abuse were most important. Adverse childhood events elevated the risk of diabetes and obesity similarly for men and women but had a greater impact on women's risk of heart disease. Discussion: Findings demonstrate the insights that can be gleaned about the early-life origins of adult health by examining operationalization of childhood exposures.
C1 [Friedman, Esther M.] RAND Corp, Santa Monica, CA 90401 USA.
   [Montez, Jennifer Karas] Syracuse Univ, Syracuse, NY USA.
   [Sheehan, Connor McDevitt] Univ Texas Austin, Austin, TX 78712 USA.
   [Guenewald, Tara L.] Univ So Calif, Los Angeles, CA USA.
   [Seeman, Teresa E.] Univ Calif Los Angeles, Los Angeles, CA USA.
C3 RAND Corporation; Syracuse University; University of Texas System;
   University of Texas Austin; University of Southern California;
   University of California System; University of California Los Angeles
RP Friedman, EM (corresponding author), RAND Corp, 1776 Main St, Santa Monica, CA 90401 USA.
EM friedman@rand.org
FU National Institute on Aging [P01-AG020166]; John D. and Catherine T.
   MacArthur Foundation Research Network on Successful Midlife Development;
   Robert Wood Johnson Foundation Health & Society Scholars Program at
   Harvard University; Eunice Kennedy Shriver National Institute of Child
   Health and Human Development [5 R24 HD042849]; UCLA CTRC grant from the
   National Institute of Health [M01-RR000865]; Older Americans
   Independence Center from the National Institute of Health [P30-AG028748]
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: This research
   was supported by a grant from the National Institute on Aging
   (P01-AG020166) to conduct a longitudinal follow-up of the MIDUS (Midlife
   in the U.S.) investigation. The original study was supported by the John
   D. and Catherine T. MacArthur Foundation Research Network on Successful
   Midlife Development. Friedman and Montez were funded in part by the
   Robert Wood Johnson Foundation Health & Society Scholars Program at
   Harvard University. Sheehan was funded in part by grant 5 R24 HD042849
   (PI: Mark D. Hayward) awarded to the Population Research Center at the
   University of Texas at Austin by the Eunice Kennedy Shriver National
   Institute of Child Health and Human Development. This work was also
   funded by grants M01-RR000865 (UCLA CTRC grant, supported MIDUS data
   collection), and P30-AG028748 (Older Americans Independence Center;
   supported MIDUS data collection) from the National Institute of Health.
CR Barker DJP, 1997, NUTRITION, V13, P807, DOI 10.1016/S0899-9007(97)00193-7
   Ben-Shlomo Y, 2002, INT J EPIDEMIOL, V31, P285, DOI 10.1093/ije/31.2.285
   Blackwell DL, 2001, SOC SCI MED, V52, P1269, DOI 10.1016/S0277-9536(00)00230-6
   Bosch NM, 2012, PSYCHONEUROENDOCRINO, V37, P1439, DOI 10.1016/j.psyneuen.2012.01.013
   Cohen S, 2004, PSYCHOSOM MED, V66, P553, DOI 10.1097/01.psy.0000126200.05189.d3
   Danese A, 2014, MOL PSYCHIATR, V19, P544, DOI 10.1038/mp.2013.54
   Felitti VJ, 1998, AM J PREV MED, V14, P245, DOI 10.1016/S0749-3797(98)00017-8
   Ferraro K.F., 2009, Handbook of theories of aging, V2nd, P413, DOI DOI 10.1017/S0144686X09990444
   Ferraro KF, 2011, HANDB SOCIOL SOC RES, P465, DOI 10.1007/978-1-4419-7374-0_29
   Ferraro KF, 2009, GERONTOLOGIST, V49, P333, DOI 10.1093/geront/gnp034
   Fisher HL, 2010, PSYCHOL MED, V40, P1967, DOI 10.1017/S0033291710000231
   Fitzgerald J, 1998, J HUM RESOUR, V33, P300, DOI 10.2307/146434
   Friedman EM, 2015, PSYCHOSOM MED, V77, P176, DOI 10.1097/PSY.0000000000000147
   Galobardes B, 2006, ANN EPIDEMIOL, V16, P91, DOI 10.1016/j.annepidem.2005.06.053
   Green JG, 2010, ARCH GEN PSYCHIAT, V67, P113, DOI 10.1001/archgenpsychiatry.2009.186
   Hall AJ, 2002, INT J EPIDEMIOL, V31, P300, DOI 10.1093/ije/31.2.300
   Hamil-Luker J, 2007, DEMOGRAPHY, V44, P137, DOI 10.1353/dem.2007.0004
   Hardt J, 2004, J CHILD PSYCHOL PSYC, V45, P260, DOI 10.1111/j.1469-7610.2004.00218.x
   Heraclides A, 2008, EUR J EPIDEMIOL, V23, P573, DOI 10.1007/s10654-008-9245-3
   Herberth G, 2008, PEDIAT ALLERG IMM-UK, V19, P722, DOI 10.1111/j.1399-3038.2008.00727.x
   Irving SM, 2006, J AGING HEALTH, V18, P458, DOI 10.1177/0898264305280994
   Kapteyn A., 2006, 2246 IZA
   Karlamangla AS, 2005, SOC SCI MED, V60, P999, DOI 10.1016/j.socscimed.2004.06.056
   Kessler RC, 1997, PSYCHOL MED, V27, P1101, DOI 10.1017/S0033291797005588
   Kestilä L, 2006, EUR J PUBLIC HEALTH, V16, P305, DOI 10.1093/eurpub/cki164
   Khlat M, 2009, SOC SCI MED, V68, P1692, DOI 10.1016/j.socscimed.2009.02.024
   KRAUSE N, 1993, J GERONTOL, V48, pP117, DOI 10.1093/geronj/48.3.P117
   Kuh D, 2002, BRIT MED J, V325, P1076, DOI 10.1136/bmj.325.7372.1076
   Lareau A, 2011, UNEQUAL CHILDHOODS: CLASS, RACE, AND FAMILY LIFE, 2ND EDITION, P1
   Lee C, 2014, SOC SCI MED, V105, P122, DOI 10.1016/j.socscimed.2014.01.017
   Lee H, 2009, POPUL RES POLICY REV, V28, P505, DOI 10.1007/s11113-008-9115-4
   Lehman BJ, 2005, PSYCHOSOM MED, V67, P846, DOI 10.1097/01.psy.0000188443.48405.eb
   Lindenberger U., 1999, BERLIN AGING STUDY A, P56, DOI DOI 10.1017/CBO9780511586545.003
   Lynch JW, 1997, SOC SCI MED, V44, P809, DOI 10.1016/S0277-9536(96)00191-8
   Maty SC, 2008, AM J PUBLIC HEALTH, V98, P1486, DOI 10.2105/AJPH.2007.123653
   McDevitt T. M., 2015, CHILD DEV ED
   Midei AJ, 2013, HEALTH PSYCHOL, V32, P121, DOI 10.1037/a0027891
   Midlife Development in the United States, 2007, MIDL US NAT STUD HLT
   Mirowsky J, 1998, RES AGING, V20, P415, DOI 10.1177/0164027598204003
   Montez JK, 2014, DEMOGRAPHY, V51, P413, DOI 10.1007/s13524-013-0261-x
   Montez JK, 2013, ADV LIFE COURSE RES, V18, P244, DOI 10.1016/j.alcr.2013.08.001
   Montez JK, 2009, J GERONTOL B-PSYCHOL, V64, P625, DOI 10.1093/geronb/gbp013
   Morton PM, 2012, J AGING HEALTH, V24, P948, DOI 10.1177/0898264312449184
   Non AL, 2014, AM J EPIDEMIOL, V180, P263, DOI 10.1093/aje/kwu127
   Radler BT, 2010, J AGING HEALTH, V22, P307, DOI 10.1177/0898264309358617
   Raftery AE, 1995, SOCIOL METHODOL, V25, P111, DOI 10.2307/271063
   Repetti RL, 2002, PSYCHOL BULL, V128, P330, DOI 10.1037/0033-2909.128.2.330
   Rich-Edwards JW, 2012, CIRCULATION, V126, P920, DOI 10.1161/CIRCULATIONAHA.111.076877
   Robinson WR, 2012, OBESITY, V20, P2464, DOI 10.1038/oby.2012.35
   ROSS CE, 1995, AM SOCIOL REV, V60, P719, DOI 10.2307/2096319
   Sapolsky R. M., 2004, Why zebras don't get ulcers: The acclaimed guide to stress, stress-related diseases, and coping
   Schafer MH, 2013, J AGING HEALTH, V25, P3, DOI 10.1177/0898264312464884
   Schilling EA, 2008, SOC SCI MED, V66, P1140, DOI 10.1016/j.socscimed.2007.11.023
   Shaw BA, 2002, J AGING HEALTH, V14, P467, DOI 10.1177/089826402237179
   Slopen N, 2013, BRAIN BEHAV IMMUN, V28, P63, DOI 10.1016/j.bbi.2012.10.018
   Slopen N, 2012, BRAIN BEHAV IMMUN, V26, P239, DOI 10.1016/j.bbi.2011.11.003
   Slopen N, 2010, PSYCHOSOM MED, V72, P694, DOI 10.1097/PSY.0b013e3181e9c16f
   Surtees PG, 2007, SOC SCI MED, V64, P95, DOI 10.1016/j.socscimed.2006.08.013
   Taylor SE, 2004, J PERS, V72, P1365, DOI 10.1111/j.1467-6494.2004.00300.x
   Thomas C, 2008, PEDIATRICS, V121, pE1240, DOI 10.1542/peds.2007-2403
   Thornberry TP, 2001, DEV PSYCHOPATHOL, V13, P957, DOI 10.1017/S0954579401004114
   Turner HA, 2006, SOC SCI MED, V62, P13, DOI 10.1016/j.socscimed.2005.05.030
   Turner RJ, 1995, J HEALTH SOC BEHAV, V36, P360, DOI 10.2307/2137325
   Yancura LA, 2009, PSYCHOL AGING, V24, P715, DOI 10.1037/a0016203
   Zill N., 1997, 98097 NCES US DEP ED
   Ziol-Guest KM, 2009, AM J PUBLIC HEALTH, V99, P527, DOI 10.2105/AJPH.2007.130575
NR 66
TC 122
Z9 143
U1 0
U2 28
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0898-2643
EI 1552-6887
J9 J AGING HEALTH
JI J. Aging Health
PD DEC
PY 2015
VL 27
IS 8
BP 1311
EP 1338
DI 10.1177/0898264315580122
PG 28
WC Gerontology; Health Policy & Services
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Health Care Sciences & Services
GA CV6HD
UT WOS:000364370400001
PM 25903978
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Niknam, M
   Olazadeh, K
   Azami, M
   Boroumandieh, S
   Yari-Boroujeni, R
   Izadi, N
   Azizi, F
   Amiri, P
AF Niknam, Mahdieh
   Olazadeh, Keyvan
   Azami, Mobin
   Boroumandieh, Saeedeh
   Yari-Boroujeni, Reza
   Izadi, Neda
   Azizi, Fereidoun
   Amiri, Parisa
TI Health-related quality of life in adults with metabolic syndrome: a
   multi-level analysis of family and individual level variation
SO BMJ OPEN
LA English
DT Article
DE Quality of Life; DIABETES & ENDOCRINOLOGY; MENTAL HEALTH; PUBLIC HEALTH
ID PHYSICAL-ACTIVITY; SOCIAL SUPPORT; RISK-FACTORS; EXERCISE; ASSOCIATION;
   COMMUNITIES; DIFFERENCE; GENDER; TIME
AB Purpose The current study aimed to investigate the associations between metabolic syndrome (MetS) with health-related quality of life (HRQoL) using multilevel analysis among the Iranian adult population. Methods This cross-sectional study was conducted in the framework of the Tehran Lipid and Glucose Study (TLGS). Participants were 6113 participants (3318 women and 2795 men) aged >= 20 years of the TLGS seventh phase who had completed data on HRQoL and MetS. HRQoL was assessed using the short-form 12-item health survey V.2 and MetS defined based on the guidelines outlined in the Joint Interim Statement. The two-level model was fitted to assess the association between MetS and HRQoL. Results The prevalence of MetS and its components was higher in men, and regardless of metabolic status, men exhibited higher HRQoL values. The deleterious impact of MetS on HRQoL was more pronounced in women, while the detrimental effects of MetS on men's HRQoL were confined to specific subscales. These results were obtained through multilevel analysis, considering both familial and individual variation levels. Moreover, our investigation highlighted the positive influence of leisure-time physical activity on both the physical and mental component summaries (PCS and MCS, respectively), regardless of gender. Education had a greater positive impact on PCS in both sexes. Additionally, a history of cardiovascular diseases was associated with a decline in mental and physical HRQoL, while age was linked to a decline in PCS and MCS, and smoking was associated with a decline in MCS. Conclusion This study revealed the significant influence of gender, as well as the unique characteristics and circumstances of individuals, on the relationship between MetS and HRQoL in a general population with low/middle income.
C1 [Niknam, Mahdieh; Olazadeh, Keyvan; Yari-Boroujeni, Reza; Izadi, Neda; Amiri, Parisa] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Res Ctr Social Determinants Hlth, Tehran, Iran.
   [Olazadeh, Keyvan] Shahid Beheshti Univ Med Sci, Sch Allied Med Sci, Dept Biostat, Tehran, Iran.
   [Azami, Mobin] Kurdistan Univ Med Sci, Student Res Comm, Sanandaj, Iran.
   [Boroumandieh, Saeedeh] Islamic Azad Univ, Fac Adv Sci & Technol, Dept Biotechnol, Tehran Med Sci, Tehran, Iran.
   [Azizi, Fereidoun] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Res Ctr, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Kurdistan University of Medical Sciences; Islamic Azad
   University; Shahid Beheshti University Medical Sciences
RP Amiri, P (corresponding author), Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Res Ctr Social Determinants Hlth, Tehran, Iran.
EM ma_niknam@sbmu.ac.ir; k1.olazadeh@gmail.com; mobinaz98@yahoo.com;
   saboroumand88@gmail.com; rezayari.sbmu@yahoo.com; neda.izady@yahoo.com;
   azizi@endocrine.ac.ir; amiri@endocrine.ac.ir
RI Azizi, Fereidoun/ABD-4136-2021; amiri, parisa/K-1575-2017; Azami,
   Mobin/AAE-5195-2022; Izadi, Neda/AIB-6552-2022
OI Amiri, Parisa/0000-0002-3198-4941; Niknam, Mahdieh/0000-0001-6694-204X
CR Adams RJ, 2010, RISK MANAG HEALTHC P, V3, P61, DOI 10.2147/RMHP.S7500
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Ali N, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-46943-x
   Amiri P, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0143167
   Azizi F, 2018, INT J ENDOCRINOL MET, V16, DOI 10.5812/ijem.84777
   Azizi F, 2014, ARCH IRAN MED, V17, P392, DOI 014176/AIM.003
   Blanquet M, 2019, DIABETES METAB SYND, V13, P1805, DOI 10.1016/j.dsx.2019.04.003
   Chen JL, 2022, J CARDIOVASC NURS, V37, P490, DOI 10.1097/JCN.0000000000000836
   Chen SH, 2020, BMJ OPEN DIAB RES CA, V8, DOI 10.1136/bmjdrc-2019-000947
   Cheraghi L, 2023, NICOTINE TOB RES, V26, P913, DOI 10.1093/ntr/ntad157
   Dalager T, 2017, BIOMED RES INT, V2017, DOI 10.1155/2017/7914134
   Davies NM, 2018, NAT HUM BEHAV, V2, P117, DOI 10.1038/s41562-017-0279-y
   De Sousa SMC, 2016, BEST PRACT RES CL OB, V37, P140, DOI 10.1016/j.bpobgyn.2016.01.006
   Deshmukh Pradeep R, 2013, Indian J Community Med, V38, P33, DOI 10.4103/0970-0218.106625
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Eknoyan G, 2002, AM J KIDNEY DIS, V39, pS14, DOI 10.1053/ajkd.2002.30939
   Esteghamati A, 2009, DIABETIC MED, V26, P745, DOI 10.1111/j.1464-5491.2009.02756.x
   Etxeberria I, 2019, QUAL LIFE RES, V28, P2221, DOI 10.1007/s11136-019-02182-0
   Fiorillo L, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19071908
   Fitzmaurice G. M., 2004, Applied Longitudinal Analysis, V2nd ed.
   Fiuza-Luces C, 2018, NAT REV CARDIOL, V15, P731, DOI 10.1038/s41569-018-0065-1
   Garson GD, 2013, Hierarchical Linear Modeling: Guide Appl, P3, DOI DOI 10.4135/9781483384450.N1
   Glazer S, 2006, INT J INTERCULT REL, V30, P605, DOI 10.1016/j.ijintrel.2005.01.013
   Güney E, 2024, FRONT PSYCHOL, V15, DOI 10.3389/fpsyg.2024.1289435
   Gurina NA, 2006, B WORLD HEALTH ORGAN, V84, P283, DOI 10.2471/BLT.05.020677
   Hajian-Tilaki K, 2017, INT J PREVENTIVE MED, V8, DOI 10.4103/ijpvm.IJPVM_197_16
   He D, 2014, ENDOCRINE, V46, P231, DOI 10.1007/s12020-013-0110-0
   Horsten M, 1999, J CARDIOVASC RISK, V6, P391
   Hu LD, 2021, CLIN REHABIL, V35, P64, DOI 10.1177/0269215520954343
   Huang IC, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0173806
   Hwang WJ, 2014, JPN J NURS SCI, V11, P23, DOI 10.1111/j.1742-7924.2012.00226.x
   Ikeda A, 2011, J EPIDEMIOL COMMUN H, V65, P71, DOI 10.1136/jech.2009.090613
   Jahangiry L, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-44486-8
   Jamali Z, 2024, SCI REP-UK, V14, DOI 10.1038/s41598-024-54367-4
   JETTE M, 1990, CLIN CARDIOL, V13, P555, DOI 10.1002/clc.4960130809
   Jha BK, 2023, DIABETOLOGY, V4, P134, DOI 10.3390/diabetology4020015
   Kandola A, 2020, ADV EXP MED BIOL, V1228, P345, DOI 10.1007/978-981-15-1792-1_23
   Karyani AK, 2016, EPIDEMIOL HEALTH, V38, DOI 10.4178/epih.e2016046
   Kowalczyk WJ, 2006, J PAIN, V7, P151, DOI 10.1016/j.jpain.2005.10.004
   Lee E, 2021, HEALTHCARE-BASEL, V9, DOI 10.3390/healthcare9030334
   Lee YJ, 2012, ANN NUTR METAB, V61, P275, DOI 10.1159/000341494
   Leping WAN., 2022, Health-related quality of life and its influencing factors in elderly people with hypertension and type 2 diabetes mellitus based on Multi-level model: take the east coastal area of China as an example
   Leyland AH, 2020, What is multilevel modelling?
   Lin YH, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-99767-y
   Liu CC, 2018, HEALTH QUAL LIFE OUT, V16, DOI 10.1186/s12955-018-0910-2
   Lobo RA, 2008, MATURITAS, V60, P10, DOI 10.1016/j.maturitas.2008.02.008
   Loucks EB, 2007, ANN EPIDEMIOL, V17, P19, DOI 10.1016/j.annepidem.2006.07.002
   Manaf MRA, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-87248-1
   Marcos-Delgado A, 2020, MED FAM-SEMERGEN, V46, P524, DOI 10.1016/j.semerg.2020.03.003
   Maruf FA, 2023, BMC SPORTS SCI MED R, V15, DOI 10.1186/s13102-023-00622-6
   Mikkelsen K, 2017, MATURITAS, V106, P48, DOI 10.1016/j.maturitas.2017.09.003
   Mohamed S.M., 2023, Food Chem Adv, V3, DOI 10.1016/j.focha.2023.100335
   Momenan AA, 2012, ARCH IRAN MED, V15, P279, DOI 012155/AIM.007
   Montazeri A, 2011, HEALTH QUAL LIFE OUT, V9, DOI 10.1186/1477-7525-9-12
   Moradi M, 2020, HEART FAIL REV, V25, P993, DOI 10.1007/s10741-019-09890-2
   Nan HR, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0058436
   Ogugu EG, 2024, BEHAV SLEEP MED, V22, P499, DOI 10.1080/15402002.2024.2314284
   portal WNd, 2023, Noncommunicable diseases data
   Puchner E, 2023, METABOLITES, V13, DOI 10.3390/metabo13050652
   Puteh SEW, 2019, BMC PUBLIC HEALTH, V19, DOI 10.1186/s12889-019-6853-7
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Ringdal GI, 2004, PALLIATIVE MED, V18, P108, DOI 10.1191/0269216304pm878oa
   Roberts D, 2016, APPL PHYSIOL NUTR ME, V41, pS108, DOI 10.1139/apnm-2015-0540
   Romero M, 2013, SPRINGERPLUS, V2, DOI 10.1186/2193-1801-2-664
   Sajid MS, 2008, INT J HEALTH CARE Q, V21, P365, DOI 10.1108/09526860810880162
   Siqeca F, 2022, HEALTH QUAL LIFE OUT, V20, DOI 10.1186/s12955-022-02080-z
   Song QB, 2015, DIABETES VASC DIS RE, V12, P189, DOI 10.1177/1479164114562410
   Sun K, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047791
   Tabatabaei-Malazy O, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0241926
   van Buuren S, 2011, J STAT SOFTW, V45, P1
   van Groenestijn AC, 2016, HEALTH QUAL LIFE OUT, V14, DOI 10.1186/s12955-016-0507-6
   Wang Q, 2022, FRONT PUBLIC HEALTH, V10, DOI 10.3389/fpubh.2022.929043
   Wiklund P, 2016, J SPORT HEALTH SCI, V5, P151, DOI 10.1016/j.jshs.2016.04.001
   Yari-Boroujeni R, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-48253-8
   Ye Y, 2023, BMC PUBLIC HEALTH, V23, DOI 10.1186/s12889-023-15584-0
   Zillikens MC, 2008, DIABETOLOGIA, V51, P2233, DOI 10.1007/s00125-008-1163-0
NR 76
TC 1
Z9 1
U1 1
U2 1
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD NOV 18
PY 2024
VL 14
IS 11
AR e087870
DI 10.1136/bmjopen-2024-087870
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA M8S4P
UT WOS:001360173600001
PM 39557558
OA gold
DA 2025-06-11
ER

PT J
AU Xu, H
   Yang, ZY
   Liu, DH
   Yu, CJ
   Zhao, Y
   Yang, JX
   Su, YZ
   Jiang, YH
   Lu, QA
AF Xu, Honglv
   Yang, Zhaoyu
   Liu, Dehui
   Yu, Chunjie
   Zhao, Yun
   Yang, Jiaxing
   Su, Yingzhen
   Jiang, Yinghong
   Lu, Qiuan
TI Mediating effect of physical sub-health in the association of
   sugar-sweetened beverages consumption with depressive symptoms in
   Chinese college students: A structural equation model
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Adolescents; Sugar-sweetened beverages; Depressive symptoms; Physical
   sub-health; Mediating effect
ID JUNK FOOD-CONSUMPTION; METABOLIC SYNDROME; MENTAL-HEALTH; PSYCHOLOGICAL
   SYMPTOMS; MAJOR DEPRESSION; SCHOOL-STUDENTS; DIET QUALITY; ADOLESCENTS;
   SAMPLE; RISK
AB Background: Although previous findings with small samples indicated that sugar-sweetened beverages (SSB) consumption was associated with depressive symptoms in adolescents, the mediating effect of physical subhealth in the association is unknown. Methods: A survey was conducted among freshmen from 11 provinces in China. A food frequency questionnaire was used to collect dietary behavior, and patient health questionnaire-9 items was used to assess depressive symptoms. A generalized linear model was used to analyze the association between SSB consumption, physical sub-health and depressive symptoms. The structural equation model was used to analyze the mediating effect of physical sub-health. Results: Of the 31,856 participants, 36.5 % had positive depressive symptoms. After adjusting for variables, carbonate beverages (8 = 0.11; 95%CI: 0.07-0.15; P = 0.000) and milk tea (8 = 0.07; 95%CI: 0.01-0.13; P = 0.021) consumption was associated with depressive symptoms in boys. Carbonate beverages (8 = 0.09; 95%CI: 0.05-0.13; P = 0.000), tea beverages (8 = 0.09; 95%CI: 0.04-0.13; P = 0.000), and milk tea (8 = 0.08; 95%CI: 0.04-0.11; P = 0.000) consumption was associated with depressive symptoms in girls. The mediating effect of physical sub-health accounted for 81.3 % of the total effect in the mediating model of SSB associated with depressive symptoms. Limitations: Retrospective survey has certain information bias. Association observed in the cross-sectional study is uncertain. Conclusions: The present study suggests that the consumption of SSB associated with depressive symptoms in Chinese college students, and physical sub-health plays a complete mediating role in the association.
C1 [Xu, Honglv; Yang, Zhaoyu; Yang, Jiaxing; Su, Yingzhen; Jiang, Yinghong; Lu, Qiuan] Kunming Univ, Sch Med, Puxin Rd 2, Kunming 650214, Yunnan, Peoples R China.
   [Xu, Honglv; Yang, Jiaxing; Su, Yingzhen; Jiang, Yinghong; Lu, Qiuan] Kunming Univ, Community Nursing Res Team, Kunming 650214, Yunnan, Peoples R China.
   [Yang, Zhaoyu; Liu, Dehui] Kunming Univ, Campus Hosp, Kunming 650214, Yunnan, Peoples R China.
   [Yu, Chunjie] First Peoples Hosp Kunming, Dept Pharm, Kunming 650100, Yunnan, Peoples R China.
   [Zhao, Yun] Yanan Hosp Kunming City, Dept Infect Control, Kunming 650051, Peoples R China.
C3 Kunming University; Kunming University; Kunming University
RP Xu, H (corresponding author), Kunming Univ, Sch Med, Puxin Rd 2, Kunming 650214, Yunnan, Peoples R China.; Xu, H (corresponding author), Kunming Univ, Community Nursing Res Team, Kunming 650214, Yunnan, Peoples R China.
EM x___hl@126.com
RI Li, Yuqing/AAR-9383-2021; Yang, Jiaxing/HMO-6544-2023
FU National Natural Science Foundation of China [82160622]; Introduced
   talents scientific research project of Kunming University [YJL2103]
FX This work was supported by the National Natural Science Foundation of
   China (82160622) and Introduced talents scientific research project of
   Kunming University (YJL2103) .
CR An J, 2014, J ADDICT MED, V8, P282, DOI 10.1097/ADM.0000000000000026
   Bakhteyar K, 2018, E MEDITERR HEALTH J, V24, P368, DOI 10.26719/2018.24.4.368
   Bangasser DA, 2021, NAT REV NEUROSCI, V22, P674, DOI 10.1038/s41583-021-00513-0
   Bi JL, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2014-005156
   Ghrouz AK, 2019, SLEEP BREATH, V23, P627, DOI 10.1007/s11325-019-01780-z
   Godos J, 2021, SLEEP MED REV, V57, DOI 10.1016/j.smrv.2021.101430
   Gui ZH, 2017, NUTRIENTS, V9, DOI 10.3390/nu9121302
   Hong SA, 2017, CHILD ADOL PSYCH MEN, V11, DOI 10.1186/s13034-017-0194-z
   Jaalouk D, 2019, EUR J NUTR, V58, P997, DOI 10.1007/s00394-018-1614-4
   Jiang De-qin, 2011, Nan Fang Yi Ke Da Xue Xue Bao, V31, P61
   Kang D, 2018, EUR J CLIN NUTR, V72, P1506, DOI 10.1038/s41430-018-0121-2
   Kappelmann N, 2021, JAMA PSYCHIAT, V78, P161, DOI 10.1001/jamapsychiatry.2020.3436
   Kassebaum N, 2017, JAMA PEDIATR, V171, P573, DOI 10.1001/jamapediatrics.2017.0250
   Khan A, 2020, ETHNIC HEALTH, V25, P34, DOI 10.1080/13557858.2017.1398313
   Khanna P, 2019, INT J PREVENTIVE MED, V10, DOI 10.4103/ijpvm.IJPVM_400_18
   Kim J, 2022, NUTR RES PRACT, V16, P194, DOI 10.4162/nrp.2022.16.2.194
   Koebnick C, 2018, BRIT J NUTR, V120, P1230, DOI 10.1017/S0007114518002726
   Kopchak Oksana, 2017, Wiad Lek, V70, P737
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178, DOI 10.4088/JCP.v69n0202
   Lapinska L, 2022, POL ARCH INTERN MED, V132, DOI 10.20452/pamw.16261
   Lassale C, 2019, MOL PSYCHIATR, V24, P965, DOI 10.1038/s41380-018-0237-8
   Lasselin J, 2014, NEUROIMMUNOMODULAT, V21, P95, DOI 10.1159/000356535
   Liu JY, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.888671
   Lu JK, 2022, FRONT PSYCHOL, V13, DOI 10.3389/fpsyg.2022.899273
   Luo CL, 2013, SLEEP, V36, P377, DOI 10.5665/sleep.2454
   Ma L, 2020, BMC PUBLIC HEALTH, V20, DOI 10.1186/s12889-020-09022-8
   Ma L, 2020, J AFFECT DISORDERS, V274, P545, DOI 10.1016/j.jad.2020.05.128
   Mainieri G, 2021, BRAIN SCI, V11, DOI 10.3390/brainsci11101259
   Marver JE, 2020, CURR OPIN PSYCHOL, V34, P63, DOI 10.1016/j.copsyc.2019.09.004
   Merikangas KR, 2010, J AM ACAD CHILD PSY, V49, P980, DOI 10.1016/j.jaac.2010.05.017
   Miller C, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030817
   Molendijk M, 2018, J AFFECT DISORDERS, V226, P346, DOI 10.1016/j.jad.2017.09.022
   Mooreville M, 2014, APPETITE, V75, P141, DOI 10.1016/j.appet.2013.12.024
   Negash A, 2020, BMC PSYCHIATRY, V20, DOI 10.1186/s12888-020-02602-3
   Ng TP, 2021, J NUTR HEALTH AGING, V25, P295, DOI 10.1007/s12603-020-1526-x
   Overby N, 2012, FOOD NUTR RES, V56, DOI 10.3402/fnr.v56i0.17231
   Park S, 2016, NUTR J, V15, DOI 10.1186/s12937-016-0204-7
   Patton GC, 2009, LANCET, V374, P881, DOI 10.1016/S0140-6736(09)60741-8
   Pulkki-Råback L, 2009, HEALTH PSYCHOL, V28, P108, DOI 10.1037/a0012646
   Ra JS, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.1058190
   Rhee SJ, 2014, PROG NEURO-PSYCHOPH, V54, P223, DOI 10.1016/j.pnpbp.2014.06.006
   Rice F, 2019, J AFFECT DISORDERS, V243, P175, DOI 10.1016/j.jad.2018.09.015
   Robles B, 2021, J BEHAV MED, V44, P212, DOI 10.1007/s10865-020-00179-6
   Rodriguez-Ayllon M, 2019, SPORTS MED, V49, P1383, DOI 10.1007/s40279-019-01099-5
   Rudel RA, 2011, ENVIRON HEALTH PERSP, V119, P914, DOI 10.1289/ehp.1003170
   Sakai H, 2017, BRIT J NUTR, V117, P1674, DOI 10.1017/S0007114517001581
   Sigala DM, 2022, NUTRIENTS, V14, DOI 10.3390/nu14081648
   Song Y, 2005, BRIT J NUTR, V93, P943, DOI 10.1079/BJN20051435
   Sun Y, 2010, J CHILD ADOL PS NURS, V23, P173, DOI 10.1111/j.1744-6171.2010.00238.x
   Tran A, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0188187
   Twenge JM, 2011, AM J ORTHOPSYCHIAT, V81, P469, DOI 10.1111/j.1939-0025.2011.01115.x
   Vrublevska J, 2018, NORD J PSYCHIAT, V72, P112, DOI 10.1080/08039488.2017.1397191
   Wan Y H, 2017, Zhonghua Yu Fang Yi Xue Za Zhi, V51, P786, DOI 10.3760/cma.j.issn.0253-9624.2017.09.003
   Wang SM, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16030340
   Wielopolski J, 2015, J AFFECT DISORDERS, V174, P310, DOI 10.1016/j.jad.2014.11.060
   Williams J, 2008, STRUCT EQU MODELING, V15, P23, DOI 10.1080/10705510701758166
   Xu H, 2023, J AFFECT DISORDERS, V320, P381, DOI 10.1016/j.jad.2022.09.156
   Xu H, 2020, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.00458
   Xu HL, 2020, ENVIRON POLLUT, V262, DOI 10.1016/j.envpol.2020.114279
   Xu HL, 2019, J AFFECT DISORDERS, V244, P155, DOI 10.1016/j.jad.2018.10.090
   Yang Rong, 2019, Wei Sheng Yan Jiu, V48, P711
   Yao Rongying, 2010, Wei Sheng Yan Jiu, V39, P212
   Yao Ying-Shui, 2012, Zhonghua Liu Xing Bing Xue Za Zhi, V33, P681
   Yao YS, 2015, INT J CLIN EXP MED, V8, P9810
   Zahedi H, 2014, NUTRITION, V30, P1391, DOI 10.1016/j.nut.2014.04.014
   Zahra J, 2014, CHILD CARE HLTH DEV, V40, P481, DOI 10.1111/cch.12068
   Zhao R, 2015, IRAN J BASIC MED SCI, V18, P1245
NR 67
TC 5
Z9 5
U1 5
U2 40
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD DEC 1
PY 2023
VL 342
BP 157
EP 165
DI 10.1016/j.jad.2023.09.020
EA SEP 2023
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA T7CA0
UT WOS:001079511500001
PM 37730148
DA 2025-06-11
ER

PT J
AU Tang, MM
   Cheng, SQ
   Wang, L
   Tang, H
   Liu, T
   Zhao, TY
   Dang, RL
AF Tang, Mimi
   Cheng, Shuqiao
   Wang, Lu
   Tang, Hui
   Liu, Ting
   Zhao, Tingyu
   Dang, Ruili
TI Decreased FGF19 and FGF21: possible underlying common pathogenic
   mechanism of metabolic and cognitive dysregulation in depression
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Article
DE FGF19; FGF21; metabolic dysregulation; cognitive dysregulation;
   depression
ID HUMAN-MEMORY; BDNF; DISORDER; INSIGHTS; BIOLOGY; STRESS; RISK
AB BackgroundAccumulating studies suggested that major depressive disorder (MDD) was closely related to metabolic syndrome (MetS). Important endogenous regulators fibroblast growth factors (FGFs) 19 and 21 were also reported to participate in psychiatric disorders. This study aimed to investigate the role of FGF19 and FGF21 in MDD and to explore the possible pathogenic mechanism of metabolic and cognitive dysregulation in depression. MethodsA total of 59 MDD patients and 55 healthy control participants were recruited. The serum levels of FGF19 and FGF21 and lipid profiles were measured by means of enzymatic methods. Cognitive function was measured by repeatable battery for the assessment of neuropsychological status (RBANS) scores. The gene expression of PGC-1 alpha and FNDC5 was determined by quantitative polymerase chain reaction (PCR). ResultsWe found that plasma FGF19 and FGF21 levels were significantly decreased in patients with MDD. Meanwhile, triglyceride (TG) was significantly elevated and PGC-1 alpha was significantly downregulated in MDD patients. Correlation analyses showed negative associations between TG and FGF19 levels. As for cognitive performance, both FGF19 and FGF21 levels were positively correlated with immediate memory. However, FGF19 levels were negatively correlated with language, and FGF21 levels were also negatively correlated with attention and delayed memory. Additionally, negative associations were found between FGF19 levels and PGC-1 alpha. FGF21 levels were positively associated with PGC-1 alpha and negatively associated with FNDC5. ConclusionThis study elucidated the role of FGF19 and FGF21 in MDD. MDD patients were confirmed to have metabolic and cognitive dysregulation, and this abnormality was linked to the decreased concentrations of FGF19 and FGF21 through the PGC-1 alpha/FNDC5 pathway. Our results showed that the alterations of FGF19 and FGF21 levels may be a common pathogenic mechanism of metabolic and cognitive disturbances in patients with MDD.
C1 [Tang, Mimi; Cheng, Shuqiao; Liu, Ting; Zhao, Tingyu] Cent South Univ, Xiangya Hosp, Dept Pharm, Changsha, Peoples R China.
   [Tang, Mimi; Cheng, Shuqiao; Liu, Ting; Zhao, Tingyu] Cent South Univ, Xiangya Hosp, Inst Rat & Safe Medicat Pract, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China.
   [Wang, Lu; Tang, Hui] Cent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha, Peoples R China.
   [Dang, Ruili] Jining Med Univ, Jining Peoples Hosp 1, Translat Pharmaceut Lab, Jining, Peoples R China.
C3 Central South University; Central South University; Central South
   University; Jining Medical University
RP Dang, RL (corresponding author), Jining Med Univ, Jining Peoples Hosp 1, Translat Pharmaceut Lab, Jining, Peoples R China.
EM ruilidang@mail.jnmc.edu.cn
RI Liu, Ting/JTV-4688-2023; Zhao, Tingyu/KAM-5354-2024
OI Zhao, Tingyu/0009-0000-5673-8328
FU National Natural Science Foundation of China [81803233, 81703625]; China
   Postdoctoral Science Foundation [2021M693561]; Natural Science
   Foundation of Hunan Province [2018JJ3834]; Science Foundation of Xiangya
   Hospital for Young Scholar [2017Q13]
FX This study was supported by the National Natural Science Foundation of
   China (No. 81803233 and 81703625), the fellowship of China Postdoctoral
   Science Foundation (2021M693561), the Natural Science Foundation of
   Hunan Province (No. 2018JJ3834), and the Science Foundation of Xiangya
   Hospital for Young Scholar (No. 2017Q13).
CR Beenken A, 2009, NAT REV DRUG DISCOV, V8, P235, DOI 10.1038/nrd2792
   Chang HH, 2018, INT J NEUROPSYCHOPH, V21, P319, DOI 10.1093/ijnp/pyx093
   D Kuipers S, 2006, CURR OPIN DRUG DISC, V9, P580
   Degirolamo C, 2016, NAT REV DRUG DISCOV, V15, P51, DOI 10.1038/nrd.2015.9
   Dolegowska K, 2019, J PHYSIOL BIOCHEM, V75, P229, DOI 10.1007/s13105-019-00675-7
   Egan MF, 2003, CELL, V112, P257, DOI 10.1016/S0092-8674(03)00035-7
   Fisher FM, 2012, GENE DEV, V26, P271, DOI 10.1101/gad.177857.111
   Gadaleta RM, 2019, NAT METAB, V1, P588, DOI 10.1038/s42255-019-0074-3
   Greenberg ME, 2009, J NEUROSCI, V29, P12764, DOI 10.1523/JNEUROSCI.3566-09.2009
   Guo A, 2021, J CELL MOL MED, V25, P3585, DOI 10.1111/jcmm.16448
   Hariri AR, 2003, J NEUROSCI, V23, P6690, DOI 10.1523/jneurosci.23-17-06690.2003
   Hsuchou H, 2013, FLUIDS BARRIERS CNS, V10, DOI 10.1186/2045-8118-10-32
   Hummel J, 2011, J CLIN PSYCHIAT, V72, P885, DOI 10.4088/JCP.09m05853blu
   Jimenez V, 2018, EMBO MOL MED, V10, DOI 10.15252/emmm.201708791
   Kharitonenkov A, 2014, MOL METAB, V3, P221, DOI 10.1016/j.molmet.2013.12.003
   Kobayashi M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12072054
   Küster OC, 2017, J ALZHEIMERS DIS, V59, P1097, DOI 10.3233/JAD-170447
   Leng Y, 2015, MOL PSYCHIATR, V20, P215, DOI 10.1038/mp.2013.192
   Liu Y, 2017, NEUROPSYCHIATRY-LOND, V7, P126, DOI [DOI 10.4172/NEUROPSYCHIATRY.1000187, 10.4172/Neuropsychiatry.1000187]
   Liu YL, 2017, PSYCHIAT RES, V252, P111, DOI 10.1016/j.psychres.2017.01.075
   Malhi GS, 2018, LANCET, V392, P2299, DOI 10.1016/S0140-6736(18)31948-2
   Omileke F, 2020, NEUROPSYCHOPHARM REP, V40, P175, DOI 10.1002/npr2.12102
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Penninx BWJH, 2017, NEUROSCI BIOBEHAV R, V74, P277, DOI 10.1016/j.neubiorev.2016.07.003
   Sa-Nguanmoo P, 2018, BIOMED PHARMACOTHER, V97, P1663, DOI 10.1016/j.biopha.2017.12.021
   Sagud M, 2009, PSYCHIAT RES, V168, P218, DOI 10.1016/j.psychres.2008.06.048
   Sarruf DA, 2010, DIABETES, V59, P1817, DOI 10.2337/db09-1878
   Scharnholz B, 2014, PSYCHONEUROENDOCRINO, V39, P104, DOI 10.1016/j.psyneuen.2013.09.030
   Somm E, 2018, ENDOCR REV, V39, P960, DOI 10.1210/er.2018-00134
   Usui N, 2021, J NEUROENDOCRINOL, V33, DOI 10.1111/jne.13026
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Wang L, 2020, J AFFECT DISORDERS, V276, P461, DOI 10.1016/j.jad.2020.07.114
   Wang QZ, 2018, MOL NEUROBIOL, V55, P4702, DOI 10.1007/s12035-017-0663-7
   Wrann CD, 2013, CELL METAB, V18, P649, DOI 10.1016/j.cmet.2013.09.008
   Zhan GF, 2018, PSYCHOPHARMACOLOGY, V235, P3351, DOI 10.1007/s00213-018-5041-2
   Zhang E, 2020, J NEUROSCI RES, V98, P537, DOI 10.1002/jnr.24510
   Zhang XY, 2015, CARDIOVASC DIABETOL, V14, DOI 10.1186/s12933-015-0190-7
NR 38
TC 3
Z9 3
U1 0
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD MAY 17
PY 2023
VL 17
AR 1165443
DI 10.3389/fnins.2023.1165443
PG 8
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA H7PD9
UT WOS:000997830000001
PM 37266540
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bai, YM
   Li, CT
   Tsai, SJ
   Tu, PC
   Chen, MH
   Su, TP
AF Bai, Ya-Mei
   Li, Cheng-Ta
   Tsai, Shih-Jen
   Tu, Pei-Chi
   Chen, Mu-Hong
   Su, Tung-Ping
TI Metabolic syndrome and adverse clinical outcomes in patients with
   bipolar disorder
SO BMC PSYCHIATRY
LA English
DT Article
DE Metabolic syndrome; Bipolar disorder; Clinical outcome
ID ADJUNCTIVE TOPIRAMATE; INSULIN-RESISTANCE; COGNITIVE FUNCTION;
   WEIGHT-GAIN; I DISORDER; OPEN-LABEL; OBESITY; BURDEN; ANTIPSYCHOTICS;
   TOLERABILITY
AB Background: Metabolic syndrome (MetS) is highly prevalent among patients with bipolar disorder. MetS may cause complications in the brain, but studies investigating MetS-associated clinical psychiatric outcomes remain scant.
   Methods: We enrolled clinically stable outpatients with bipolar disorder aged 18-65 years and performed anthropometric and fasting biochemical assessments to investigate MetS prevalence. We then performed clinical assessments by using the Young Mania Rating Scale for manic symptoms, the Montgomery-Osberg Depression Rating Scale for depressive symptoms, the Positive and Negative Symptom Scale for psychotic symptoms, the Involuntary Movement Scale for tardive dyskinesia, the Barnes Akathisia Rating Scale for akathisia, the Udvalg for Kliniske Undersogelser for general side effects, the Schedule for Assessment of Insight for insight, the Global Assessment of Functioning scale for global functioning, and the Wisconsin Card Sorting Test (WCST) for cognitive executive function.
   Results: In total, 143 patients were enrolled and had a MetS prevalence of 29.4%. The patients treated with atypical antipsychotics plus mood stabilizers (36.3%) and atypical antipsychotics alone (36.0%) had a significantly higher prevalence of MetS than did those treated with mood stabilizers alone (10.5%; p = 0.012). According to multivariate regression analyses adjusted for age, sex, smoking status, bipolar disorder subtype (I or II), pharmacological treatment duration, and psychiatric medication, compared with patients without MetS, those with MetS had significantly more previous hospitalizations (p = 0.036), severer tardive dyskinesia (p = 0.030), poorer insight (p = 0.036), poorer global function (p = 0.046), and more impaired executive function (conceptual level response on the WCST; p = 0.042).
   Conclusions: Our results indicated that patients with comorbid bipolar disorder and MetS have more adverse clinical outcomes than those without, with more hospitalizations, severer tardive dyskinesia, poorer insight, poorer global function, and more impaired executive function. Monitoring MetS is crucial for assessing not only physical burden, but also psychiatric outcomes.
C1 [Bai, Ya-Mei; Li, Cheng-Ta; Tsai, Shih-Jen; Tu, Pei-Chi; Chen, Mu-Hong; Su, Tung-Ping] Taipei Vet Gen Hosp, Dept Psychiat, Taipei, Taiwan.
   [Bai, Ya-Mei; Li, Cheng-Ta; Tsai, Shih-Jen; Tu, Pei-Chi; Chen, Mu-Hong; Su, Tung-Ping] Natl Yang Ming Univ, Dept Psychiat, Coll Med, Taipei, Taiwan.
C3 Taipei Veterans General Hospital; National Yang Ming Chiao Tung
   University
RP Bai, YM (corresponding author), Taipei Vet Gen Hosp, Dept Psychiat, Taipei, Taiwan.; Bai, YM (corresponding author), Natl Yang Ming Univ, Dept Psychiat, Coll Med, Taipei, Taiwan.
EM ymbi@mail2000.com.tw
RI Chen, MuHong/ACJ-6131-2022; Li, Cheng-Ta/AAI-5759-2021; Tsai,
   Shih-Jen/AAK-7944-2020
OI Li, Cheng-Ta/0000-0002-0670-1153
FU Taiwan Ministry of Science and Technology [MOST 104-2314-B-075-017];
   Taipei Veterans General Hospital [V103E9-005, V103E3-006]
FX The study was supported by grants from the Taiwan Ministry of Science
   and Technology (MOST 104-2314-B-075-017), and Taipei Veterans General
   Hospital (V103E9-005, V103E3-006). These funding resources are
   independent of the study.
CR [Anonymous], FAT CHANCE SLIM NONE
   Bai YM, 2014, J AFFECT DISORDERS, V166, P187, DOI 10.1016/j.jad.2014.05.009
   Bai YM, 2013, J CHIN MED ASSOC, V76, P547, DOI 10.1016/j.jcma.2013.06.013
   Baker RW, 2004, BRIT J PSYCHIAT, V185, P472, DOI 10.1192/bjp.185.6.472
   Barbosa IG, 2011, EUR ARCH PSY CLIN N, V261, P139, DOI 10.1007/s00406-010-0116-z
   BARNES TRE, 1989, BRIT J PSYCHIAT, V154, P672, DOI 10.1192/bjp.154.5.672
   Calkin C, 2009, BIPOLAR DISORD, V11, P650, DOI 10.1111/j.1399-5618.2009.00730.x
   Calkin CV, 2015, BRIT J PSYCHIAT, V206, P52, DOI 10.1192/bjp.bp.114.152850
   Carlson BX, 2012, BIPOLAR DISORD, V14, P41, DOI 10.1111/j.1399-5618.2011.00974.x
   Cerit C, 2010, PSYCHOPHARMACOL BULL, V43, P22
   Chang HH, 2009, J AFFECT DISORDERS, V117, P124, DOI 10.1016/j.jad.2008.12.018
   Correll CU, 2010, BIPOLAR DISORD, V12, P116, DOI 10.1111/j.1399-5618.2010.00798.x
   Crump C, 2013, JAMA PSYCHIAT, V70, P931, DOI 10.1001/jamapsychiatry.2013.1394
   DAVID A, 1992, BRIT J PSYCHIAT, V161, P599, DOI 10.1192/bjp.161.5.599
   Depp CA, 2014, BIPOLAR DISORD, V16, P422, DOI 10.1111/bdi.12200
   Fagiolini A, 2003, AM J PSYCHIAT, V160, P112, DOI 10.1176/appi.ajp.160.1.112
   Fagiolini A, 2008, CNS DRUGS, V22, P655, DOI 10.2165/00023210-200822080-00004
   Gabriel A, 2007, EAT WEIGHT DISORD-ST, V12, P48
   Galling B, 2015, EXPERT OPIN DRUG SAF, V14, P1181, DOI 10.1517/14740338.2015.1053457
   Galvez JF, 2014, J AFFECT DISORDERS, V168, P306, DOI 10.1016/j.jad.2014.05.054
   Goldstein BI, 2013, BIPOLAR DISORD, V15, P284, DOI 10.1111/bdi.12035
   Goldstein BI, 2011, BIPOLAR DISORD, V13, P387, DOI 10.1111/j.1399-5618.2011.00932.x
   Grover Sandeep, 2012, Indian J Psychol Med, V34, P110, DOI 10.4103/0253-7176.101767
   Guloksuz S, 2010, J AFFECT DISORDERS, V126, P458, DOI 10.1016/j.jad.2010.04.027
   Kemp DE, 2010, BIPOLAR DISORD, V12, P404, DOI 10.1111/j.1399-5618.2010.00823.x
   Ketter Terence A, 2006, Psychopharmacol Bull, V39, P120
   Lackner N, 2016, WORLD J BIOL PSYCHIA, V17, P535, DOI 10.3109/15622975.2015.1046917
   Laursen TM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0067133
   Lingjaerde O, 1987, Acta Psychiatr Scand Suppl, V334, P1
   Liu YT, 2014, ASIA-PAC PSYCHIAT, V6, P226, DOI 10.1111/j.1758-5872.2012.00223.x
   Löffler D, 2016, J PSYCHIATR RES, V72, P37, DOI 10.1016/j.jpsychires.2015.10.008
   Lopresti AL, 2013, PROG NEURO-PSYCHOPH, V45, P92, DOI 10.1016/j.pnpbp.2013.05.005
   McElroy SL, 2014, J CLIN PSYCHIAT, V75, P46, DOI [10.4088/JCP.13010tx4c, 10.4088/JCP.13r08634]
   McIntyre Roger S, 2008, Curr Psychiatry Rep, V10, P66, DOI 10.1007/s11920-008-0012-7
   McIntyre RS, 2010, J AFFECT DISORDERS, V126, P366, DOI 10.1016/j.jad.2010.04.012
   McIntyre RS, 2005, CAN J PSYCHIAT, V50, P415, DOI 10.1177/070674370505000705
   MUNETZ MR, 1986, J CLIN PSYCHIAT, V47, P75
   Ruzickova M, 2003, CAN J PSYCHIAT, V48, P458, DOI 10.1177/070674370304800705
   SIMPSON GM, 1970, ACTA PSYCHIAT SCAND, P11
   Song SW, 2015, BRAIN IMAGING BEHAV, V9, P588, DOI 10.1007/s11682-014-9311-2
   Sylvia LG, 2015, BIPOLAR DISORD, V17, P212, DOI 10.1111/bdi.12243
   Szlagatys-Sidorkiewicz A, 2013, J PEDIATR GASTR NUTR, V56, P382, DOI 10.1097/MPG.0b013e318275f95c
   Szulinska M, 2013, EUR REV MED PHARMACO, V17, P1916
   Tramontina S, 2007, J CHILD ADOL PSYCHOP, V17, P129, DOI 10.1089/cap.2006.0024
   Treviño S, 2015, SYNAPSE, V69, P421, DOI 10.1002/syn.21832
   Vancampfort D, 2013, AM J PSYCHIAT, V170, P265, DOI 10.1176/appi.ajp.2012.12050620
   Vieta E, 2002, J CLIN PSYCHOPHARM, V22, P431, DOI 10.1097/00004714-200208000-00017
   Yatham LN, 2013, BIPOLAR DISORD, V15, P1, DOI 10.1111/bdi.12025
   Yim CY, 2012, EUR PSYCHIAT, V27, P223, DOI 10.1016/j.eurpsy.2011.02.004
NR 49
TC 38
Z9 41
U1 0
U2 8
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD DEC 15
PY 2016
VL 16
AR 448
DI 10.1186/s12888-016-1143-8
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EF5TE
UT WOS:000390391700001
PM 27978821
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Grienke, U
   Kaserer, T
   Pfluger, F
   Mair, CE
   Langer, T
   Schuster, D
   Rollinger, JM
AF Grienke, Ulrike
   Kaserer, Teresa
   Pfluger, Florian
   Mair, Christina E.
   Langer, Thierry
   Schuster, Daniela
   Rollinger, Judith M.
TI Accessing biological actions of Ganoderma secondary metabolites
   by in silico profiling
SO PHYTOCHEMISTRY
LA English
DT Article
DE Ganoderma lucidum; Ganodermataceae; Pharmacophore profiling; Virtual
   screening; Triterpenes; Antiviral targets; Metabolic syndrome
ID PHARMACOPHORE-BASED DISCOVERY; ALDOSE REDUCTASE; FRUITING BODIES;
   MINERALOCORTICOID RECEPTOR; ADIPOCYTE DIFFERENTIATION; CONFORMER
   GENERATION; INHIBITORY-ACTIVITY; OXIDATIVE STRESS; HIGH-THROUGHPUT;
   LUCIDUM
AB The species complex around the medicinal fungus Ganoderma lucidum Karst. (Ganodermataceae) is widely known in traditional medicines, as well as in modern applications such as functional food or nutraceuticals. A considerable number of publications reflects its abundance and variety in biological actions either provoked by primary metabolites, such as polysaccharides, or secondary metabolites, such as lanostane-type triterpenes. However, due to this remarkable amount of information, a rationalization of the individual Ganoderma constituents to biological actions on a molecular level is quite challenging. To overcome this issue, a database was generated containing meta-information, i.e., chemical structures and biological actions of hitherto identified Ganoderma constituents (279). This was followed by a computational approach subjecting this 3D multi-conformational molecular dataset to in silica parallel screening against an in-house collection of validated structure- and ligand-based 3D pharmacophore models. The predictive power of the evaluated in silica tools and hints from traditional application fields served as criteria for the model selection. Thus, the focus was laid on representative druggable targets in the field of viral infections (5) and diseases related to the metabolic syndrome (22). The results obtained from this in silico approach were compared to bioactivity data available from the literature. 89 and 197 Ganoderma compounds were predicted as ligands of at least one of the selected pharmacological targets in the antiviral and the metabolic syndrome screening, respectively. Among them only a minority of individual compounds (around 10%) has ever been investigated on these targets or for the associated biological activity. Accordingly, this study discloses putative ligand target interactions for a plethora of Ganoderma constituents in the empirically manifested field of viral diseases and metabolic syndrome which serve as a basis for future applications to access yet undiscovered biological actions of Ganoderma secondary metabolites on a molecular level. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Grienke, Ulrike; Mair, Christina E.; Rollinger, Judith M.] Univ Innsbruck, Inst Pharm Pharmacognosy, A-6020 Innsbruck, Austria.
   [Grienke, Ulrike; Mair, Christina E.; Rollinger, Judith M.] Univ Innsbruck, Ctr Mol Biosci Innsbruck, A-6020 Innsbruck, Austria.
   [Kaserer, Teresa; Pfluger, Florian; Schuster, Daniela] Univ Innsbruck, Inst Pharm Pharmacognosy Chem, Comp Aided Mol Design Grp, Ctr Mol Biosci Innsbruck, A-6020 Innsbruck, Austria.
   [Langer, Thierry] Univ Vienna, Fac Life Sci, Dept Pharmaceut Chem, A-1090 Vienna, Austria.
   [Rollinger, Judith M.] Univ Vienna, Fac Life Sci, Dept Pharmacognosy, A-1090 Vienna, Austria.
C3 University of Innsbruck; University of Innsbruck; University of
   Innsbruck; University of Vienna; University of Vienna
RP Grienke, U (corresponding author), Univ Innsbruck, Inst Pharm Pharmacognosy, Innrain 80-82, A-6020 Innsbruck, Austria.
EM ulrike.grienke@uibk.ac.at
RI Rollinger, Judith/Q-5996-2019; Grienke, Ulrike/H-2585-2017; Schuster,
   Daniela/C-1024-2014; Langer, Thierry/U-8621-2017
OI Kaserer, Teresa/0000-0003-0372-1885; Grienke,
   Ulrike/0000-0003-0305-9270; Rollinger, Judith/0000-0001-6581-0774;
   Schuster, Daniela/0000-0002-9933-8938; Langer,
   Thierry/0000-0002-5242-1240
FU Austrian Science Fund [FWF: P24587]; foundation "Verein zur Forderung
   der wissenschaftlichen Ausbildung und Tatigkeit von Sudtirolern an der
   Landesuniversitat Innsbruck"; Austrian Science Fund (FWF) [P24587]
   Funding Source: Austrian Science Fund (FWF)
FX U.G. and C.E.M. are grateful for their positions funded by the Austrian
   Science Fund (FWF: P24587). T.K. was supported by the foundation "Verein
   zur Forderung der wissenschaftlichen Ausbildung und Tatigkeit von
   Sudtirolern an der Landesuniversitat Innsbruck". D.S. thanks the
   University for her position within the Erika Cremer Habilitation
   Program. We thank OpenEye and Inte:Ligand for providing their software
   under special academic Grant agreements free of charge.
CR Alexopoulou A, 2012, WORLD J GASTROENTERO, V18, P6060, DOI 10.3748/wjg.v18.i42.6060
   [Anonymous], 2011, PIP PIL REL 8 5
   [Anonymous], MALAYSIAN J SCI
   [Anonymous], 2008, OMEGA VERS 2 3 2
   [Anonymous], 2008, CHEMBIODRAW ULTR 11
   Arts EJ, 2012, CSH PERSPECT MED, V2, DOI 10.1101/cshperspect.a007161
   Barros L, 2008, FOOD CHEM TOXICOL, V46, P2742, DOI 10.1016/j.fct.2008.04.030
   Berger A, 2004, Lipids Health Dis, V3, P2, DOI 10.1186/1476-511X-3-2
   Bryzgalova G, 2008, J STEROID BIOCHEM, V111, P262, DOI 10.1016/j.jsbmb.2008.06.010
   Chapman MJ, 2010, EUR HEART J, V31, P149, DOI 10.1093/eurheartj/ehp399
   D'Amore S, 2013, BBA-MOL BASIS DIS, V1832, P2289, DOI 10.1016/j.bbadis.2013.09.006
   Duwensee K, 2011, ATHEROSCLEROSIS, V219, P109, DOI 10.1016/j.atherosclerosis.2011.07.023
   El Dine RS, 2008, J NAT PROD, V71, P1022, DOI 10.1021/np8001139
   El Dine RS, 2009, J NAT PROD, V72, P2019, DOI 10.1021/np900279u
   El-Mekkawy S, 1998, PHYTOCHEMISTRY, V49, P1651, DOI 10.1016/S0031-9422(98)00254-4
   Eo SK, 1999, J ETHNOPHARMACOL, V68, P129, DOI 10.1016/S0378-8741(99)00067-7
   Fakhrudin N, 2010, MOL PHARMACOL, V77, P559, DOI 10.1124/mol.109.062141
   Fatmawati S, 2009, PHYTOTHER RES, V23, P28, DOI 10.1002/ptr.2425
   Fatmawati S, 2011, BIOORG MED CHEM LETT, V21, P7295, DOI 10.1016/j.bmcl.2011.10.035
   Fatmawati S, 2010, FITOTERAPIA, V81, P1033, DOI 10.1016/j.fitote.2010.06.025
   Fatmawati S, 2010, PLANTA MED, V76, P1691, DOI 10.1055/s-0030-1249782
   Feher M, 2003, J CHEM INF COMP SCI, V43, P218, DOI 10.1021/ci0200467
   Gathercole LL, 2013, ENDOCR REV, V34, P525, DOI 10.1210/er.2012-1050
   Goel RK, 2011, MED CHEM RES, V20, P1509, DOI 10.1007/s00044-010-9398-y
   Goldberg AC, 2013, J CLIN LIPIDOL, V7, pS16, DOI 10.1016/j.jacl.2013.03.003
   Grienke U, 2011, BIOORGAN MED CHEM, V19, P6779, DOI 10.1016/j.bmc.2011.09.039
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Hawkins PCD, 2012, J CHEM INF MODEL, V52, P2919, DOI 10.1021/ci300314k
   Hawkins PCD, 2010, J CHEM INF MODEL, V50, P572, DOI 10.1021/ci100031x
   Huang SP, 2009, PHARM BIOL, V47, P111, DOI 10.1080/13880200802439244
   Huang ZY, 2011, J FOOD BIOCHEM, V35, P1508, DOI 10.1111/j.1745-4514.2010.00472.x
   Johnson TO, 2002, NAT REV DRUG DISCOV, V1, P696, DOI 10.1038/nrd895
   Jung SH, 2005, PHYTOTHER RES, V19, P477, DOI 10.1002/ptr.1638
   KABIR Y, 1988, J NUTR SCI VITAMINOL, V34, P433, DOI 10.3177/jnsv.34.433
   Kagaya Y., 2001, Research Communications in Pharmacology and Toxicology, V6, P135
   Kamali Amanda, 2013, Infect Drug Resist, V6, P187, DOI 10.2147/IDR.S36601
   KANMATSUSE K, 1985, YAKUGAKU ZASSHI, V105, P942, DOI 10.1248/yakushi1947.105.10_942
   Kim HW, 1997, ARCH PHARM RES, V20, P425, DOI 10.1007/BF02973934
   La Cava A, 2004, NAT REV IMMUNOL, V4, P371, DOI 10.1038/nri1350
   Lai LK, 2010, INT J MED MUSHROOMS, V12, P279, DOI 10.1615/IntJMedMushr.v12.i3.70
   Larsson J, 2005, J NAT PROD, V68, P985, DOI 10.1021/np049655u
   Ledford RM, 2004, J VIROL, V78, P3663, DOI 10.1128/JVI.78.7.3663-3674.2004
   Lee SH, 2006, ARCH PHARM RES, V29, P479, DOI 10.1007/BF02969420
   LEE SY, 1990, CHEM PHARM BULL, V38, P1359, DOI 10.1248/cpb.38.1359
   Li CJ, 2006, NAT PROD RES, V20, P985, DOI 10.1080/14786410600921466
   Lindequist Ulrike, 2010, Med Monatsschr Pharm, V33, P40
   Liu J, 2012, FOOD CHEM, V133, P1034, DOI 10.1016/j.foodchem.2012.01.034
   Markt P, 2008, J MED CHEM, V51, P6303, DOI 10.1021/jm800128k
   Markt P, 2007, J COMPUT AID MOL DES, V21, P575, DOI 10.1007/s10822-007-9140-0
   Markt P, 2009, J MED CHEM, V52, P369, DOI 10.1021/jm801044g
   Marzolla V, 2012, MOL CELL ENDOCRINOL, V350, P281, DOI 10.1016/j.mce.2011.09.011
   McArdle BM, 2007, CHEMBIOCHEM, V8, P788, DOI 10.1002/cbic.200700035
   Min BS, 1998, CHEM PHARM BULL, V46, P1607, DOI 10.1248/cpb.46.1607
   Mizushina Y, 1999, BIOORGAN MED CHEM, V7, P2047, DOI 10.1016/S0968-0896(99)00121-2
   Mohammed A., 2009, Int J Med Med Sci, V1, P530
   Mothana RAA, 2003, FITOTERAPIA, V74, P177, DOI 10.1016/S0367-326X(02)00305-2
   Nambu H, 2008, DIABETES RES CLIN PR, V82, P18, DOI 10.1016/j.diabres.2008.03.023
   Niedermeyer THJ, 2005, J NAT PROD, V68, P1728, DOI 10.1021/np0501886
   Noha SM, 2011, BIOORG MED CHEM LETT, V21, P577, DOI 10.1016/j.bmcl.2010.10.051
   Odermatt A, 2012, MOL CELL ENDOCRINOL, V350, P168, DOI 10.1016/j.mce.2011.07.020
   Pan D, 2014, BIOPOLYMERS, V101, P613, DOI 10.1002/bip.22426
   Rollinger JM, 2012, BIOACTIVE COMPOUNDS FROM NATURAL SOURCES: NATURAL PRODUCTS AS LEAD COMPOUNDS IN DRUG DISCOVERY, 2ND EDITION, P97
   Rollinger JM, 2009, PHYTOCHEM LETT, V2, P53, DOI 10.1016/j.phytol.2008.12.002
   Rollinger JM, 2009, PLANTA MED, V75, P195, DOI 10.1055/s-0028-1088397
   Russell R, 2006, PHYTOCHEMISTRY, V67, P1985, DOI 10.1016/j.phytochem.2006.07.004
   San Diego: Accelrys Software Inc, 2012, DISC STUD MOD ENV RE
   Sanodiya BS, 2009, CURR PHARM BIOTECHNO, V10, P717, DOI 10.2174/138920109789978757
   Sato N, 2009, J NAT PROD, V72, P958, DOI 10.1021/np800687t
   Schuster D., 2010, DRUG DISCOV TODAY, V7, P205
   Schuster D, 2006, J MED CHEM, V49, P3454, DOI 10.1021/jm0600794
   Schuster D, 2011, BIOORGAN MED CHEM, V19, P7168, DOI 10.1016/j.bmc.2011.09.056
   Schuster D, 2010, BIOORGAN MED CHEM, V18, P5071, DOI 10.1016/j.bmc.2010.05.071
   Scior T, 2012, J CHEM INF MODEL, V52, P867, DOI 10.1021/ci200528d
   Scott SA, 2014, BBA-MOL CELL BIOL L, V1841, P1060, DOI 10.1016/j.bbalip.2014.01.009
   Seto SW, 2009, PHYTOMEDICINE, V16, P426, DOI 10.1016/j.phymed.2008.10.004
   Shimojo Y, 2011, PHYTOTHER RES, V25, P202, DOI 10.1002/ptr.3242
   Steindl T, 2005, QSAR COMB SCI, V24, P470, DOI 10.1002/qsar.200430929
   Steindl T, 2004, J CHEM INF COMP SCI, V44, P1849, DOI 10.1021/ci049844i
   Steindl TM, 2006, J COMPUT AID MOL DES, V20, P703, DOI 10.1007/s10822-006-9066-y
   Steindl TM, 2006, J CHEM INF MODEL, V46, P2146, DOI 10.1021/ci6002043
   Steindl TM, 2005, J MED CHEM, V48, P6250, DOI 10.1021/jm050343d
   Szedlay Gyongyi, 2002, Acta Microbiologica et Immunologica Hungarica, V49, P235, DOI 10.1556/AMicr.49.2002.2-3.9
   Tang WH, 2012, FRONT PHARMACOL, V3, DOI 10.3389/fphar.2012.00087
   Teng BS, 2012, EUR REV MED PHARMACO, V16, P166
   Teng BS, 2011, J AGR FOOD CHEM, V59, P6492, DOI 10.1021/jf200527y
   Thyagarajan-Sahu A, 2011, BMC COMPLEM ALTERN M, V11, DOI 10.1186/1472-6882-11-74
   Tornatore L, 2012, TRENDS CELL BIOL, V22, P557, DOI 10.1016/j.tcb.2012.08.001
   von Grafenstein S, 2012, J CHEM INF MODEL, V52, P1391, DOI 10.1021/ci300096c
   Vuorinen A, 2014, MOL INFORM, V33, P15, DOI 10.1002/minf.201300063
   Wang CD, 2012, BRIT J NUTR, V108, P2014, DOI 10.1017/S0007114512000153
   Wermuth C.G., 1998, ANNU REP MED CHEM, V33, P385
   Wolber G, 2005, J CHEM INF MODEL, V45, P160, DOI 10.1021/ci049885e
   Yan Z, 2013, BIOMED CHROMATOGR, V27, P1560, DOI 10.1002/bmc.2960
   Zhao J, 2006, J SEP SCI, V29, P2609, DOI 10.1002/jssc.200600178
NR 94
TC 30
Z9 32
U1 0
U2 34
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9422
J9 PHYTOCHEMISTRY
JI Phytochemistry
PD JUN
PY 2015
VL 114
SI SI
BP 114
EP 124
DI 10.1016/j.phytochem.2014.10.010
PG 11
WC Biochemistry & Molecular Biology; Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Plant Sciences
GA CK9HS
UT WOS:000356551800010
PM 25457486
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Rosenson, RS
   Huskin, AL
   Wolff, DA
   Helenowski, IB
   Rademaker, AW
AF Rosenson, Robert S.
   Huskin, Anna L.
   Wolff, David A.
   Helenowski, Irene B.
   Rademaker, Alfred W.
TI Fenofibrate reduces fasting and postprandial inflammatory responses
   among hypertriglyceridemia patients with the metabolic syndrome
SO ATHEROSCLEROSIS
LA English
DT Article
DE cytokines; oxidative stress; very low-density lipoprotein;
   hypertriglyceridemia; metabolic syndrome
ID PPAR-ALPHA ACTIVATORS; C-REACTIVE PROTEIN; KAPPA-B; COMBINED
   HYPERLIPIDEMIA; LIPID-PEROXIDATION; RISK; MARKERS; LIPOPROTEINS;
   DENSITY; SUSCEPTIBILITY
AB Objective: To examine the effects of fenofibrate ( 160 mg/d) therapy on fasting and postprandial cytokine production in subjects with metabolic syndrome and hypertriglyceridemia.
   Research design and methods: Randomized, double-blind, controlled trial that compared the effects of 3-month therapy with placebo and fenolibrate on fasting and postprandial cytokine production in 55 subjects with metabolic syndrome and elevated fasting triglycerides (>= 1.7 and <6.78 mmol/L).
   Results: Fenofibrate treatment reduced concentrations of monohydroxy fatty acids (OH-FA) by 15.5% (p = 0.001), lipopolysaccharide activated monocyte chemotactic protein-1 (MCP-1/CCL2) production in fasting blood samples by 3.4% (p=0.01 vs. placebo), macrophage inflammatory protein-1 alpha (MIP-1 alpha/CCU) by 3.5% (p=0.01), and interleukin-1 beta (IL-1 beta) by 2.5% (p=0.04). After a standardized fat load (50kg/m(2)), OH-FA were reduced by 31.0% (p <0.0001), MCP-1/CCL2 was reduced by 5.2% (p=0.002), MIP-1 alpha/CCL3 by 3.9% (p=0.007), and IL-I beta by 3.4% (p=0.02). Reductions in MCP-1/CCL2, MIP-1 alpha/CCL3, and IL-1 beta production correlated with changes in fasting and postprandial large very low-density lipoprotein (VLDL) (all p < 0.005) and small low-density lipoprotein (LDL) particles (all p < 0.05). In stepwise regression models that included age, gender, weight change, and drug assignment, large VLDL particles were associated with reductions in postprandial MCP-1/CCL2 (p = 0.042), MIP-1 alpha/CCL3 (p = 0.003), and IL-1 beta (p = 0.02).
   Conclusions: This study reports that fenofibrate reduces whole blood production of inflammatory cytokines and hepatic-synthesized inflammatory proteins, and the anti-inflammatory effects of fenofibrate therapy involve VLDL- and LDL-mediated pathways. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
C1 [Rosenson, Robert S.] Univ Michigan, Div Cardiovasc Med, Ann Arbor, MI 48106 USA.
   [Huskin, Anna L.; Wolff, David A.] Northwestern Univ, Feinberg Sch Med, Div Cardiol, Lipoprotein & Hemorheol Res Facil, Chicago, IL 60611 USA.
   [Helenowski, Irene B.; Rademaker, Alfred W.] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA.
C3 University of Michigan System; University of Michigan; Northwestern
   University; Feinberg School of Medicine; Northwestern University;
   Feinberg School of Medicine
RP Rosenson, RS (corresponding author), Univ Michigan, Div Cardiovasc Med, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106 USA.
EM rrosenso@umich.edu
RI Rosenson, Robert/MDS-6957-2025
CR Chaput E, 1999, LIPIDS, V34, P497, DOI 10.1007/s11745-999-0390-8
   Cipollone F, 2003, CIRCULATION, V108, P1070, DOI 10.1161/01.CIR.0000086014.80477.0D
   CLAUSS A., 1957, ACTA HAEMATOL, V17, P237
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   DEGRAAF J, 1991, ARTERIOSCLER THROMB, V11, P298, DOI 10.1161/01.ATV.11.2.298
   Delerive P, 1999, J BIOL CHEM, V274, P32048, DOI 10.1074/jbc.274.45.32048
   Delerive P, 2000, J BIOL CHEM, V275, P36703, DOI 10.1074/jbc.M004045200
   Doi H, 1999, ARTERIOSCL THROM VAS, V19, P1918, DOI 10.1161/01.ATV.19.8.1918
   Freedman DS, 2004, CLIN CHEM, V50, P1189, DOI 10.1373/clinchem.2004.032763
   Herder C, 2006, DIABETOLOGIA, V49, P921, DOI 10.1007/s00125-006-0190-y
   Herder C, 2006, DIABETES CARE, V29, P368, DOI 10.2337/diacare.29.02.06.dc05-1474
   Inoue I, 2001, METABOLISM, V50, P3, DOI 10.1053/meta.2001.19415
   Jonkers IJ, 2002, AM J MED, V112, P275, DOI 10.1016/S0002-9343(01)01123-8
   Kaikkonen J, 2004, SCAND J CLIN LAB INV, V64, P457, DOI 10.1080/00365510410006667
   Koh KK, 2005, DIABETES CARE, V28, P1419, DOI 10.2337/diacare.28.6.1419
   Marx N, 1999, CIRCULATION, V99, P3125, DOI 10.1161/01.CIR.99.24.3125
   Natarajan R, 2001, ARTERIOSCL THROM VAS, V21, P1408, DOI 10.1161/hq0901.095278
   Okopien B, 2006, J CLIN ENDOCR METAB, V91, P1770, DOI 10.1210/jc.2005-1615
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   Rosenson RS, 2005, CURR PROB CARDIOLOGY, V30, P241, DOI 10.1016/j.cpcardiol.2004.10.001
   Rosenson RS, 2005, J LAB CLIN MED, V145, P83, DOI 10.1016/j.lab.2004.11.012
   Sebestjen M, 2004, THROMB HAEMOSTASIS, V92, P1129, DOI 10.1160/TH03-04-0250
   Staels B, 1998, NATURE, V393, P790, DOI 10.1038/31701
   Tangney CC, 1997, AM J CLIN NUTR, V65, P36, DOI 10.1093/ajcn/65.1.36
   TRIBBLE DL, 1992, ATHEROSCLEROSIS, V93, P189, DOI 10.1016/0021-9150(92)90255-F
   Wang TD, 2003, ATHEROSCLEROSIS, V170, P315, DOI 10.1016/S0021-9150(03)00296-X
   Zambon A, 2006, ARTERIOSCL THROM VAS, V26, P977, DOI 10.1161/01.ATV.0000204327.96431.9a
NR 28
TC 27
Z9 28
U1 0
U2 3
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD JUN
PY 2008
VL 198
IS 2
BP 381
EP 388
DI 10.1016/j.atherosclerosis.2007.12.007
PG 8
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 319AH
UT WOS:000257133600019
PM 18242616
DA 2025-06-11
ER

PT J
AU Bedi, N
   Dwivedi, D
   Kaur, N
   Chamola, S
   Tripathi, S
   Abrol, P
AF Bedi, Nidhi
   Dwivedi, Deepti
   Kaur, Nimarpreet
   Chamola, Sunil
   Tripathi, Saurabh
   Abrol, Pankaj
TI Effect of Educational Intervention as Cognitive Behavioural Therapy for
   Intake of Junk Food, Sugar-sweetened Beverages and Energy Drinks among
   Medical Students from India: A Prospective Interventional Study
SO JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
LA English
DT Article
DE Communicable disease; Health education; Metabolic syndrome
ID METABOLIC SYNDROME; OBESITY; GUIDELINES; OVERWEIGHT; IMPACT
AB Introduction: Junk food intake has increased many folds in the last two decades. India is still struggling with communicable diseases, though the incidence of non communicable diseases, including metabolic syndrome, has increased several times in the younger age group. There is a scarcity of data and a limited number of international studies on decreasing junk food intake, especially in India. Aim: To assess eating habits, nutritional status, and the effect of behavioural therapy on junk food intake in medical undergraduate students. Materials and Methods: A prospective interventional study was conducted in medical students of a tertiary care hospital in Northern India (Faculty of Medicine and Health Sciences, SGT University, Haryana, India) over a duration of six months, from October 2021 to March 2022. All students were given a pretest in the form of an electronic questionnaire. Students then received four educational sessions based on Cognitive Behavioural Therapy (CBT), one session per week, each lasting 30 minutes. At the end of the four sessions, all students were assessed through a post-test following the same protocol as the pretest. Statistical analysis was conducted using Statistical Packages for Social Sciences (SPSS) version 28.0 The Wilcoxon's signed-rank test was applied for comparison within pre and post-interventions. Results: Most of the students, 302 (68%), included in the study were less than 20 years of age, with a minimum age of 17 years and a maximum age of 25 years. A total of 443 students were included in the study. Of these, 178 out of 443 had a Body Mass Index (BMI)>25 kg/m(2) , classifying them as overweight (40.18%). The majority of students were not aware of the major side effects of junk food intake, but a significant improvement was noted in the post-test conducted four weeks later. A significant change (p<0.0001) was observed in the frequency of intake of junk food, sugar -sweetened beverages, and energy drinks, decreasing significantly after the four educational sessions. Conclusion: Short educational intervention programs, as part of cognitive -behavioural theory, have a significant impact on improving awareness and reducing the intake of junk food. More studies of longer duration and involving other components of CBT should be conducted to assess their impact on physical and mental health.
C1 [Bedi, Nidhi; Abrol, Pankaj] Fac Med & Hlth Sci, Dept Paediat, Gurugram, Haryana, India.
   [Dwivedi, Deepti; Kaur, Nimarpreet] Fac Med & Hlth Sci, Dept Physiol, Gurugram, Haryana, India.
   [Chamola, Sunil; Tripathi, Saurabh] Fac Med & Hlth Sci, Dept Community Med, Gurugram, Haryana, India.
RP Dwivedi, D (corresponding author), A2-301 Unitech Residences,Sect 33, Gurugram 122001, Haryana, India.
EM deeptidwd86@gmail.com
RI Abrol, Pankaj/AAK-6376-2021
CR Ashakiran, 2012, J KRISHNA INST MED S, V1, P7
   Bairwa Mohan, 2013, Indian J Community Med, V38, P185, DOI 10.4103/0970-0218.116358
   Bedi N, 2014, INDIAN PEDIATR, V51, P529, DOI 10.1007/s13312-014-0441-9
   Bhushan C., 2017, Burden of packaged food on schoolchildren: Based on the CSE survey know your diet
   Chadha DS, 2009, METAB SYNDR RELAT D, V7, P151, DOI 10.1089/met.2008.0054
   Dixon HG, 2007, SOC SCI MED, V65, P1311, DOI 10.1016/j.socscimed.2007.05.011
   Donato KA, 1998, ARCH INTERN MED, V158, P1855, DOI 10.1001/archinte.158.17.1855
   Fister Kristina, 2005, BMJ, V331, P1426, DOI 10.1136/bmj.331.7530.1426-c
   Goel K, 2010, HEART, V96, P579, DOI 10.1136/hrt.2009.183236
   Gupta P, 2019, INDIAN PEDIATR, V56, P849, DOI 10.1007/s13312-019-1612-5
   Kaushik JS, 2011, INDIAN PEDIATR, V48, P97, DOI 10.1007/s13312-011-0035-8
   Mehta S, 2021, International J Recent Technology and Engineering, V10, P117
   Misra A, 2008, J CLIN ENDOCR METAB, V93, pS9, DOI 10.1210/jc.2008-1595
   Nayak R. K., 2020, INT J COMMUN MED PUB, V7, P1839, DOI [10.18203/2394-6040.ijcmph20201991, DOI 10.18203/2394-6040.IJCMPH20201991]
   Ochoa-Avilés A, 2017, NUTR J, V16, DOI 10.1186/s12937-017-0299-5
   Shree V, 2018, Int J Community Med Public Health, V5, P2750
   Singh UK, 2020, J NUTR METAB, V2020, DOI 10.1155/2020/7932324
   Tsiros MD, 2008, AM J CLIN NUTR, V87, P1134, DOI 10.1093/ajcn/87.5.1134
   Wasir JS, 2004, METAB SYNDR RELAT D, V2, P14, DOI 10.1089/met.2004.2.14
NR 19
TC 0
Z9 0
U1 2
U2 5
PU PREMCHAND SHANTIDEVI RESEARCH FOUNDATION
PI DELHI
PA 71 JAIN COLONY, VEER NAGAR, DELHI, 110 007, INDIA
SN 2249-782X
EI 0973-709X
J9 J CLIN DIAGN RES
JI J. Clin. Diagn. Res.
PD MAY
PY 2024
VL 18
IS 5
BP OC1
EP OC6
DI 10.7860/JCDR/2024/66955.19342
PG 6
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA QS4W8
UT WOS:001222857200054
OA gold
DA 2025-06-11
ER

PT J
AU Polovina, M
   Dikic, D
   Vlajkovic, A
   Viotijevic, M
   Milinkovic, I
   Asanin, M
   Ostojic, M
   Coats, AJS
   Seferovic, PM
AF Polovina, Marija
   Dikic, Dijana
   Vlajkovic, Ana
   Viotijevic, Matej
   Milinkovic, Ivan
   Asanin, Milika
   Ostojic, Miodrag
   Coats, Andrew J. S.
   Seferovic, Petar M.
TI Adverse cardiovascular outcomes in atrial fibrillation: Validation of
   the new 2MACE risk score
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Atrial fibrillation; Major adverse cardiovascular event; Risk score;
   Metabolic syndrome; Myocardial infarction; Cardiac death
ID ACUTE MYOCARDIAL-INFARCTION; HEART-FAILURE; HYPERTENSIVE PATIENTS;
   ATHEROSCLEROSIS RISK; METABOLIC SYNDROME; CLINICAL-FEATURES; CORONARY;
   PREVALENCE; MANAGEMENT; MORTALITY
AB Background: In addition to thromboembolism, atrial fibrillation (AF) may also predispose to major adverse cardiovascular events (MACE) attributable to coronary artery disease (CAD), including myocardial infarction (MI). The 2MACE score (2 points -Metabolic syndrome and Age >= 75 years, 1 point - MI/revascularization, Congestive heart failure/ejection-fraction <40%, and thrombo-Embolism) was recently proposed to help identify AF patients at risk of MACE. We assessed the predictive validity of the 2MACE score for MACE occurrence in AF patients free of CAD at baseline.
   Methods: Non-valvular AF patients (n = 794) without CAD (mean-age, 62.5 +/- 12.1 years, metabolic syndrome, 34.0%; heart failure/ejection-fraction <40%, 25.7%; thromboembolism, 9.7%) were prospectively followed for 5 years, or until MACE (composite of non-fatal/fatal MI, revascularization and cardiovascular death). At inclusion, CAD was excluded by medical history, exercise-stress testing and/or coronary angiography. Also, the 2MACE score was determined.
   Results: At follow-up, 112 patients experienced MACE (2.8%/year). The 2MACE score demonstrated adequate discrimination (C-statistic, 0.699; 95% confidence interval [CI], 0.648-0.750; P < 0.001) and calibration (Hosmer-Lemeshow P = 0.79) for MACE. The score was significantly associated with MACE, with the adjusted Hazard Ratio (aHR) of 1.56 (95% CI, 1.35-1.73; P < 0.001). As for individual outcomes, the score predicted MI (n = 46; aHR, 1.49; 95% CI 1.23-1.80), revascularization (n = 32; aHR, 1.41; 95% CI, 1.11-1.80) and cardiovascular death (n = 34; aHR, 1.43; 95% CI, 1.14-1.81), all P < 0.001.
   Conclusions: The 2MACE score successfully predicts future MACE, including incident MI, coronary revascularization and cardiovascular death in AF patients free of CAD at baseline. It may have a role in risk-stratification and primary prevention of MACE in AF patients. (C) 2017 Elsevier B.V. All rights reserved.
C1 [Polovina, Marija; Dikic, Dijana; Milinkovic, Ivan; Asanin, Milika; Seferovic, Petar M.] Clin Ctr Serbia, Dept Cardiol, 26 Visegradska, Belgrade 11000, Serbia.
   [Polovina, Marija; Vlajkovic, Ana; Viotijevic, Matej; Asanin, Milika; Ostojic, Miodrag; Seferovic, Petar M.] Univ Belgrade, Sch Med, 8 Doktora Subotica, Belgrade 11000, Serbia.
   [Coats, Andrew J. S.] San Raffaele Pisana Sci Inst, Via Pisana 235, I-00163 Rome, Italy.
C3 Clinical Centre of Serbia; University of Belgrade; IRCCS San Raffaele
   Pisana
RP Seferovic, PM (corresponding author), Clin Ctr Serbia, Dept Cardiol, 26 Visegradska, Belgrade 11000, Serbia.
EM seferovic.petar@gmail.com
RI Povzun, Anton/Q-1460-2016; Coats, Andrew/E-4451-2012
OI Polovina, Marija/0000-0001-9589-0023
CR Akar JG, 2008, J AM COLL CARDIOL, V51, P1790, DOI 10.1016/j.jacc.2007.11.083
   Asanin M, 2005, EUR J HEART FAIL, V7, P671, DOI 10.1016/j.ejheart.2004.07.018
   Bayturan O, 2017, EUR J PREV CARDIOL, V24, P373, DOI 10.1177/2047487316679265
   BENJAMIN EJ, 1994, JAMA-J AM MED ASSOC, V271, P840, DOI 10.1001/jama.271.11.840
   Camm AJ, 2016, EUR HEART J, V37, P1145, DOI 10.1093/eurheartj/ehv466
   Camm AJ, 2012, EUR HEART J, V33
   Chamberlain AM, 2010, AM HEART J, V159, P850, DOI 10.1016/j.ahj.2010.02.005
   Chao TF, 2014, HEART RHYTHM, V11, P1941, DOI 10.1016/j.hrthm.2014.08.003
   Christersson C., 2012, EUR HEART J, V33
   Chugh SS, 2014, CIRCULATION, V129, P837, DOI 10.1161/CIRCULATIONAHA.113.005119
   COCKCROFT DW, 1976, NEPHRON, V16, P31, DOI 10.1159/000180580
   Corbanese U, 2011, CHEST, V139, P1247, DOI 10.1378/chest.10-2995
   DELONG ER, 1988, BIOMETRICS, V44, P837, DOI 10.2307/2531595
   Dries DL, 1998, J AM COLL CARDIOL, V32, P695, DOI 10.1016/S0735-1097(98)00297-6
   Freestone B, 2008, THROMB RES, V122, P85, DOI 10.1016/j.thromres.2007.09.008
   Go AS, 2001, JAMA-J AM MED ASSOC, V285, P2370, DOI 10.1001/jama.285.18.2370
   Goto S, 2008, AM HEART J, V156, P855, DOI 10.1016/j.ahj.2008.06.029
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Guo XY, 2016, ATHEROSCLEROSIS, V254, P1, DOI 10.1016/j.atherosclerosis.2016.09.011
   Guo YT, 2012, J AM COLL CARDIOL, V60, P2263, DOI 10.1016/j.jacc.2012.04.063
   Hicks KA, 2015, J AM COLL CARDIOL, V66, P403, DOI [10.1016/j.jacc.2014.12.018, 10.1007/s12350-015-0209-1]
   Hosmer DW, 1997, STAT MED, V16, P965
   Kim EJ, 2016, AM HEART J, V177, P138, DOI 10.1016/j.ahj.2016.03.023
   Kirchhof P, 2016, EUR HEART J, V37, P2893, DOI 10.1093/eurheartj/ehw210
   Kochiadakis GE, 2002, EUR HEART J, V23, P734, DOI 10.1053/euhj.2001.2894
   Li J, 2010, HEART RHYTHM, V7, P438, DOI 10.1016/j.hrthm.2009.12.009
   Lim HS, 2013, J AM COLL CARDIOL, V61, P852, DOI 10.1016/j.jacc.2012.11.046
   Lip GYH, 2015, EUR J HEART FAIL, V17, P570, DOI 10.1002/ejhf.254
   Lip GYH, 2010, STROKE, V41, P2731, DOI 10.1161/STROKEAHA.110.590257
   Miyasaka Y, 2007, J AM COLL CARDIOL, V49, P986, DOI 10.1016/j.jacc.2006.10.062
   O'Neal WT, 2014, CLIN CARDIOL, V37, P750, DOI 10.1002/clc.22339
   Pastori D, 2016, INTERN EMERG MED, V11, P199, DOI 10.1007/s11739-015-1326-1
   Pastori D, 2015, CHEST, V147, P1644, DOI 10.1378/chest.14-2414
   Perri L, 2015, INT J CARDIOL, V179, P139, DOI 10.1016/j.ijcard.2014.10.039
   Polovina M, 2013, VOJNOSANIT PREGL, V70, P908, DOI 10.2298/VSP110429016P
   Polovina MM, 2015, MEDIAT INFLAMM, V2015, DOI 10.1155/2015/653026
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Sandoval Y, 2014, J AM COLL CARDIOL, V63, P2079, DOI 10.1016/j.jacc.2014.02.541
   Schmitt J, 2009, EUR HEART J, V30, P1038, DOI 10.1093/eurheartj/ehn579
   Senoo K, 2014, J CARDIOL, V63, P123, DOI 10.1016/j.jjcc.2013.08.007
   Sever PS, 2003, LANCET, V361, P1149, DOI 10.1016/S0140-6736(03)12948-0
   Shibata T, 2015, CIRCULATION, V132, P241, DOI 10.1161/CIRCULATIONAHA.114.015134
   Soliman EZ, 2015, CIRCULATION, V131, P1843, DOI 10.1161/CIRCULATIONAHA.114.014145
   Soliman EZ, 2014, JAMA INTERN MED, V174, pE107, DOI 10.1001/jamainternmed.2013.11912
   Thygesen K, 2007, CIRCULATION, V116, P2634, DOI [10.1161/CIRCULATIONAHA.107.187397, 10.1016/j.jacc.2007.09.011]
   Violi F, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.116.003347
   Wachtell K, 2005, J AM COLL CARDIOL, V45, P705, DOI 10.1016/j.jacc.2004.06.080
   Wändell P, 2016, INT J CARDIOL, V221, P789, DOI 10.1016/j.ijcard.2016.07.119
   Winkel TA, 2010, EUR J VASC ENDOVASC, V40, P9, DOI 10.1016/j.ejvs.2010.03.003
NR 49
TC 22
Z9 22
U1 0
U2 12
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD DEC 15
PY 2017
VL 249
BP 191
EP 197
DI 10.1016/j.ijcard.2017.09.154
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FL5ZZ
UT WOS:000414326300039
PM 28986061
DA 2025-06-11
ER

PT J
AU Madani, Z
   Louchami, K
   Sener, A
   Malaisse, WJ
   Yahia, DA
AF Madani, Zohra
   Louchami, Karim
   Sener, Abdullah
   Malaisse, Willy J.
   Yahia, Dalila Ait
TI Dietary sardine protein lowers insulin resistance, leptin and TNF-α and
   beneficially affects adipose tissue oxidative stress in rats with
   fructose-induced metabolic syndrome
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Article
DE metabolic syndrome; fructose; sardine protein; rats
ID C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA; FREE FATTY-ACIDS; COD
   PROTEIN; SKELETAL-MUSCLE; FISH CONSUMPTION; GLUCOSE; RISK; MEN;
   SENSITIVITY
AB The present study aims at exploring the effects of sardine protein on insulin resistance, plasma lipid profile, as well as oxidative and inflammatory status in rats with fructose-induced metabolic syndrome. Rats were fed sardine protein (S) or casein (C) diets supplemented or not with high-fructose (HF) for 2 months. Rats fed the HF diets had greater body weight and adiposity and lower food intake as compared to control rats. Increased plasma glucose, insulin, HbA1C, triacylglycerols, free fatty acids and impaired glucose tolerance and insulin resistance was observed in HF-fed rats. Moreover, a decline in adipose tissues antioxidant status and a rise in lipid peroxidation and plasma TNF-alpha and fibrinogen were noted. Rats fed sardine protein diets exhibited lower food intake and fat mass than those fed casein diets. Sardine protein diets diminished plasma insulin and insulin resistance. Plasma triacylglyeerol and free fatty acids were also lower, while those of a-tocopherol, taurine and calcium were enhanced as compared to casein diets. Moreover, S-HF diet significantly decreased plasma glucose and HbA1C. Sardine protein consumption lowered hydroperoxide levels in pen renal and brown adipose tissues. The S-HF diet, as compared to C-HF diet decreased epididymal hydroperoxides. Feeding sardine protein diets decreased brown adipose tissue carbonyls and increased glutathione peroxidase activity. Perirenal and epididymal superoxide dismutase and catalase activities and brown catalase activity were significantly greater in S-HF group than in C-HF group. Sardine protein diets also prevented hyperleptinemia and reduced inflammatory status in comparison with rats fed casein diets. Taken together, these results support the beneficial effect of sardine protein in fructose-induced metabolic syndrome on such variables as hyperglycemia, insulin resistance, hyperlipidemia and oxidative and inflammatory status, suggesting the possible use of sardine protein as a protective strategy against insulin resistance and related situations.
C1 [Louchami, Karim; Sener, Abdullah; Malaisse, Willy J.] Univ Libre Bruxelles, Lab Expt Hormonol, B-1070 Brussels, Belgium.
   [Madani, Zohra; Yahia, Dalila Ait] Es Senia Univ, Dept Biol, Oran, Algeria.
C3 Universite Libre de Bruxelles; Universite d'Oran
RP Malaisse, WJ (corresponding author), Univ Libre Bruxelles, Lab Expt Hormonol, 808 Route Lennik, B-1070 Brussels, Belgium.
EM malaisse@ulb.ac.be
CR Aebi H, 1974, METHODS ENZYM ANAL, V2nd, P673, DOI [10.1016/B978-0-12-091302-2.50032-3, DOI 10.1016/B978-0-12-091302-2.50032-3]
   Aguilera CM, 2008, CLIN SCI, V114, P183, DOI 10.1042/CS20070115
   Ailhaud G, 2006, CR BIOL, V329, P570, DOI 10.1016/j.crvi.2005.12.012
   [Anonymous], METAB FUNCT RES DIAB
   BAKER H, 1980, NUTR REP INT, V21, P531
   Bergmeyer HU, 1974, METHOD ENZYMAT AN, V3, P1190
   Casaschi A, 2005, METABOLISM, V54, P403, DOI 10.1016/j.metabol.2004.09.016
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Council of European Communities, 1987, CORRIGENDUM OFFICI L
   Council of European Communities, 1986, OFFICIAL J L
   El Mesallamy HO, 2010, DIABETOL METAB SYNDR, V2, DOI 10.1186/1758-5996-2-46
   Eymard S, 2003, EUR J LIPID SCI TECH, V105, P497, DOI 10.1002/ejlt.200300768
   FESKENS EJM, 1991, DIABETES CARE, V14, P935, DOI 10.2337/diacare.14.11.935
   Ghanim H, 2004, CIRCULATION, V110, P1564, DOI 10.1161/01.CIR.0000142055.53122.FA
   Hinault C, 2006, DIABETOLOGIA, V49, P1017, DOI 10.1007/s00125-006-0201-z
   HOTAMISLIGIL GS, 1995, J CLIN INVEST, V95, P2409, DOI 10.1172/JCI117936
   Kannappan S, 2009, INDIAN J MED RES, V129, P401
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Kim JK, 2000, J BIOL CHEM, V275, P8456, DOI 10.1074/jbc.275.12.8456
   Lavigne C, 2000, AM J PHYSIOL-ENDOC M, V278, pE491, DOI 10.1152/ajpendo.2000.278.3.E491
   Lavigne C, 2001, AM J PHYSIOL-ENDOC M, V281, pE62, DOI 10.1152/ajpendo.2001.281.1.E62
   Lê KA, 2006, CURR OPIN CLIN NUTR, V9, P469, DOI 10.1097/01.mco.0000232910.61612.4d
   LECLERCQMEYER V, 1985, ENDOCRINOLOGY, V116, P1168, DOI 10.1210/endo-116-3-1168
   LEVINE RL, 1990, METHOD ENZYMOL, V186, P464
   Moran TH, 2009, J NUTR, V139, pS1253, DOI 10.3945/jn.108.097956
   Naderali EK, 2003, ATHEROSCLEROSIS, V166, P253, DOI 10.1016/S0021-9150(02)00367-2
   Nakamura Y, 2007, METABOLISM, V56, P1060, DOI 10.1016/j.metabol.2007.03.014
   Nandhini ATA, 2002, AMINO ACIDS, V22, P27
   Nguyen MTA, 2007, J BIOL CHEM, V282, P35279, DOI 10.1074/jbc.M706762200
   Ouellet V, 2008, J NUTR, V138, P2386, DOI 10.3945/jn.108.092346
   Ouellet V, 2007, DIABETES CARE, V30, P2816, DOI 10.2337/dc07-0273
   Patel C, 2007, J CLIN ENDOCR METAB, V92, P4476, DOI 10.1210/jc.2007-0778
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   QUINTANILHA AT, 1982, ANN NY ACAD SCI, V393, P32, DOI 10.1111/j.1749-6632.1982.tb31230.x
   Rajasekar P., 2006, DIABETOL CROAT, V34, P87
   Ridker PM, 2004, CIRCULATION, V109, P2818, DOI 10.1161/01.CIR.0000132467.45278.59
   Rudkowska I, 2010, PHYSIOL GENOMICS, V40, P189, DOI 10.1152/physiolgenomics.00120.2009
   Shirai N, 2002, COMP BIOCHEM PHYS B, V131, P387, DOI 10.1016/S1096-4959(01)00507-3
   Shukla A, 2006, BRIT J NUTR, V96, P674, DOI 10.1079/BJN20061895
   Stanhope KL, 2008, CURR OPIN LIPIDOL, V19, P16, DOI 10.1097/MOL.0b013e3282f2b24a
   Tappy L, 2010, PHYSIOL REV, V90, P23, DOI 10.1152/physrev.00019.2009
   Tremblay F, 2003, DIABETES, V52, P29, DOI 10.2337/diabetes.52.1.29
   Tripathy D, 2003, DIABETES, V52, P2882, DOI 10.2337/diabetes.52.12.2882
   Undeland I, 2002, J AGR FOOD CHEM, V50, P7371, DOI 10.1021/jf020199u
   Winkler G, 2003, EUR J ENDOCRINOL, V149, P129, DOI 10.1530/eje.0.1490129
   Wong ND, 2007, AM J CARDIOVASC DRUG, V7, P259, DOI 10.2165/00129784-200707040-00004
   Yokozawa T, 2008, J AGR FOOD CHEM, V56, P5026, DOI 10.1021/jf800213f
   Zampelas A, 2005, J AM COLL CARDIOL, V46, P120, DOI 10.1016/j.jacc.2005.03.048
NR 48
TC 65
Z9 73
U1 0
U2 15
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD FEB
PY 2012
VL 29
IS 2
BP 311
EP 318
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 872QQ
UT WOS:000298824800027
PM 22085913
OA Bronze
DA 2025-06-11
ER

PT J
AU Papazoglou, K
   Tuttle, BM
AF Papazoglou, Konstantinos
   Tuttle, Brooke McQuerrey
TI Fighting Police Trauma: Practical Approaches to Addressing Psychological
   Needs of Officers
SO SAGE OPEN
LA English
DT Article
DE police trauma; police stress; psychological support; clinical
   intervention; police health promotion; police psychological well-being;
   police job performance
ID HOME-VISIT INTERVENTION; LAW-ENFORCEMENT; POSTTRAUMATIC-STRESS;
   OCCUPATIONAL STRESS; METABOLIC SYNDROME; JOB STRESS; WORK; RESILIENCE;
   STRATEGIES; INCIDENTS
AB Stress and trauma experienced by police officers in the line of duty can have negative impacts on officers' health and well-being. Psychological support is imperative to help officers maintain psychological well-being and to perform their duties efficiently. However, officers are often skeptical to seek psychological support. The reasons behind such skepticism vary. Specifically, officers may believe that clinicians do not understand police work. In addition, inquiries by clinicians into personal and early life experiences may be interpreted as attempts to patronize officers; as a result, police officers' identities as those who serve and protect may be disparaged in the context of therapy. This article recommends a number of evidence and practice-based actions that clinicians may employ to approach police culture and develop effective clinical support for officers who suffer from the debilitating effects of police-related stress and trauma. Recommendations for empirical research and clinical practice are discussed.
C1 [Papazoglou, Konstantinos] Ontario Minist Community Safety & Correct Serv, Justice Sect, 109 McLaughlin Rd S, Brampton, ON L6Y 2C8, Canada.
   [Papazoglou, Konstantinos] Univ Toronto, Dept Psychol, Mississauga Campus, Mississauga, ON, Canada.
   [Tuttle, Brooke McQuerrey] Oklahoma State Univ, Ctr Family Resilience, Tulsa, OK USA.
C3 University of Toronto; University Toronto Mississauga
RP Papazoglou, K (corresponding author), Ontario Minist Community Safety & Correct Serv, Justice Sect, 109 McLaughlin Rd S, Brampton, ON L6Y 2C8, Canada.
EM konstantinos.papazoglou@ontario.ca
RI Papazoglou, Konstantinos/Y-3587-2019
CR Addis ME, 2003, AM PSYCHOL, V58, P5, DOI 10.1037/0003-066X.58.1.5
   Andersen J.P., 2016, General Medicine, V4, P1, DOI DOI 10.4172/2327-5146.1000225
   Andersen J.P., 2014, TRAUMATOLOGY, V20, P182, DOI DOI 10.1037/H0099403
   Andersen J.P., 2015, International Journal of Emergency Mental Health and Human Resilience, V17, P661, DOI DOI 10.4172/1522-4821.1000259
   Andersen JP, 2016, J OCCUP ENVIRON MED, V58, pE242, DOI 10.1097/JOM.0000000000000756
   Andersen JP, 2015, SAGE OPEN, V5, DOI 10.1177/2158244015580380
   Anderson GS, 2002, POLICING, V25, P399, DOI 10.1108/13639510210429437
   Anderson J.P., 2015, Journal of Law Enforcement, V5, P1, DOI DOI 10.1177/2158244015590446
   [Anonymous], 2015, CBC News
   [Anonymous], 2015, Final Report of the President's Task Force on 21st Century Policing
   [Anonymous], COMM AFF COMM PART P
   Barren JR, 2005, POLICING, V28, P255, DOI 10.1108/13639510510597898
   Berg AM, 2006, J OCCUP HEALTH, V48, P145, DOI 10.1539/joh.48.145
   Berking M, 2010, BEHAV THER, V41, P329, DOI 10.1016/j.beth.2009.08.001
   Bernstein Mary., 2002, Journal of Contemporary Criminal Justice, V18, P302, DOI DOI 10.1177/1043986202018003006
   Brodie PJ, 2012, J FAM PSYCHOTHER, V23, P20, DOI 10.1080/08975353.2012.654082
   BURKE RJ, 1993, STRESS MEDICINE, V9, P171, DOI 10.1002/smi.2460090308
   Carlan PE, 2008, J POLICE CRIM PSYCHO, V23, P8, DOI 10.1007/s11896-008-9015-x
   Chongruksa D, 2012, COUNS PSYCHOL Q, V25, P83, DOI 10.1080/09515070.2012.666424
   Chopko B.A., 2009, Journal of Mental Health Counseling, V31, P363, DOI DOI 10.17744/MEHC.31.4.9W6LHK4V66423385
   Chopko BA, 2011, J CREAT MENT HEALTH, V6, P315, DOI 10.1080/15401383.2011.630304
   Chopko BA, 2013, J LOSS TRAUMA, V18, P1, DOI 10.1080/15325024.2012.674442
   Cohen HowardS., 1991, Power and Restraint: The Moral Dimension of Police Work
   Dowling FG, 2006, AM J PSYCHIAT, V163, P151, DOI 10.1176/appi.ajp.163.1.151
   Figley C.R., 1995, Compassion fatigue: Toward a new understanding of the costs of caring, P3, DOI DOI 10.4037/CCN2015392
   Galatzer-Levy IR, 2013, EMOTION, V13, P545, DOI 10.1037/a0031314
   Gersons BPR, 2000, J TRAUMA STRESS, V13, P333, DOI 10.1023/A:1007793803627
   GOODE WJ, 1960, AM SOCIOL REV, V25, P483, DOI 10.2307/2092933
   Haarr RN, 2013, POLICE Q, V16, P395, DOI 10.1177/1098611113489888
   Hansson L, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/1471-244X-14-55
   Hartley Tara A, 2011, Int J Emerg Ment Health, V13, P211
   Henry V.E., 2004, DEATH WORK
   HENRY VE, 1995, BEHAV SCI LAW, V13, P93, DOI 10.1002/bsl.2370130107
   Hyland P, 2012, J POLICE CRIM PSYCHO, V27, P129, DOI 10.1007/s11896-012-9103-9
   Joseph PN, 2009, J OCCUP ENVIRON MED, V51, P700, DOI 10.1097/JOM.0b013e3181a02252
   Karlsson I, 2006, POLICING, V29, P524, DOI 10.1108/13639510610684746
   Lindinger-Sternart S., 2015, INT J SOCIAL SCI STU, V3, P1, DOI [DOI 10.11114/IJSSS.V3IL.519, 10.11114/ijsss.v3i1.519, DOI 10.11114/IJSSS.V3I1.519]
   Lindsay V, 2009, J POLICE CRIM PSYCHO, V24, P87, DOI 10.1007/s11896-009-9048-9
   Litz BT, 2009, CLIN PSYCHOL REV, V29, P695, DOI 10.1016/j.cpr.2009.07.003
   Maguen S.Litz., 2016, Moral injury in the context of war
   Manzella C, 2014, INT J MENT HEALTH PR, V16, P103, DOI 10.1080/14623730.2014.903609
   Marans Steven., 1995, POLICE MENTAL HLTH P
   Marmar CR, 2006, ANN NY ACAD SCI, V1071, P1, DOI 10.1196/annals.1364.001
   Ménard KS, 2013, INT J STRESS MANAGE, V20, P37, DOI 10.1037/a0031434
   Miller L, 1995, PSYCHOTHER, V32, P592, DOI 10.1037/0033-3204.32.4.592
   Miller L., 2004, J POLICE CRIM PSYCHO, V19, P30, DOI DOI 10.1007/BF02813871
   Miller L, 2007, AM J FAM THER, V35, P21, DOI 10.1080/01926180600698541
   Papazoglou K., 2014, TRAUMATOLOGY INT J, V20, P103, DOI [DOI 10.1037/H0099394, 10.1037/h0099394]
   Papazoglou K., 2013, TRAUMATOLOGY, V19, P196, DOI DOI 10.1177/1534765612466151
   Papazoglou K., 2016, International Journal of Medical and Health Sciences, V5, P121
   Pasillas RM, 2006, J POLICE CRIM PSYCHO, V21, P41, DOI 10.1007/BF02849501
   Patterson GT, 2003, J CRIM JUST, V31, P215, DOI 10.1016/S0047-2352(03)00003-5
   Payne B.K., 2003, Journal of Criminal Justice Education, V14, P327, DOI DOI 10.1080/10511250300085821
   Peres JFP, 2011, J PSYCHIATR RES, V45, P727, DOI 10.1016/j.jpsychires.2010.11.004
   Pinfold V, 2005, INT REV PSYCHIATR, V17, P123, DOI 10.1080/09540260500073638
   Roberts NA, 2001, J MARRIAGE FAM, V63, P1052, DOI 10.1111/j.1741-3737.2001.01052.x
   Roberts NA, 2013, FAM PROCESS, V52, P271, DOI 10.1111/j.1545-5300.2012.01415.x
   Royle Liz, 2009, Int J Emerg Ment Health, V11, P79
   Rudofossi D., 2009, COP DOCS GUIDE PUBLI
   Salston M, 2003, J TRAUMA STRESS, V16, P167, DOI 10.1023/A:1022899207206
   Sharp ML, 2015, EPIDEMIOL REV, V37, P144, DOI 10.1093/epirev/mxu012
   Steinkopf BL, 2015, PROF PSYCHOL-RES PR, V46, P348, DOI 10.1037/pro0000042
   Stepka E, 2014, MED PR, V65, P229
   Stover CS, 2008, VIOLENCE AGAINST WOM, V14, P1430, DOI 10.1177/1077801208327019
   Stover CS, 2009, VIOLENCE VICTIMS, V24, P591, DOI 10.1891/0886-6708.24.5.591
   Thompson MM., 2006, Int J Stress Manag, V13, P494, DOI [DOI 10.1037/1072-5245.13.4.494, 10.1037/1072-5245.13.4.494]
   Tolin DF, 1999, BEHAV THER, V30, P527, DOI 10.1016/S0005-7894(99)80023-9
   Vallejo AR, 2011, TER PSICOL, V29, P13, DOI 10.4067/S0718-48082011000100002
   Violanti J.M., 2003, International Journal of Emergency Mental Health, V6, P75
   Violanti JM, 2009, ARCH ENVIRON OCCUP H, V64, P194, DOI 10.1080/19338240903241259
   Wester SR, 2005, PROF PSYCHOL-RES PR, V36, P51, DOI 10.1037/0735-7028.36.1.51
   Wester SR, 2010, PSYCHOL MEN MASCULIN, V11, P286, DOI 10.1037/a0019108
   White AK, 2016, J POLICE CRIM PSYCHO, V31, P141, DOI 10.1007/s11896-015-9175-4
   Wirth MD, 2014, J OCCUP ENVIRON MED, V56, P986, DOI 10.1097/JOM.0000000000000213
   Woody RH, 2005, PROF PSYCHOL-RES PR, V36, P525, DOI 10.1037/0735-7028.36.5.525
   Zhao T.S., 2002, Police Quartely, V5, P43, DOI [10.1177/109861110200500103, DOI 10.1177/109861110200500103]
NR 76
TC 39
Z9 75
U1 1
U2 19
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2158-2440
J9 SAGE OPEN
JI SAGE Open
PD AUG 22
PY 2018
VL 8
IS 3
AR 2158244018794794
DI 10.1177/2158244018794794
PG 11
WC Social Sciences, Interdisciplinary
WE Social Science Citation Index (SSCI)
SC Social Sciences - Other Topics
GA GR3WD
UT WOS:000442527000001
OA gold
DA 2025-06-11
ER

PT J
AU Naz, MSG
   Noroozzadeh, M
   Ardebili, SN
   Mousavi, M
   Azizi, F
   Tehrani, FR
AF Naz, Marzieh Saei Ghare
   Noroozzadeh, Mahsa
   Ardebili, Shahla Noori
   Mousavi, Maryam
   Azizi, Fereidoun
   Tehrani, Fahimeh Ramezani
TI Cardio-Metabolic Risk Profile of Women With Endometriosis: A
   Population-Based Study
SO ENDOCRINOLOGY DIABETES & METABOLISM
LA English
DT Article
DE diabetes; endometriosis; hypertension; metabolic syndrome; Tehran Lipid
   and Glucose Study
ID CORONARY-HEART-DISEASE; PERITONEAL-FLUID; CHOLESTEROL; INFLAMMATION;
   SERUM; EPIDEMIOLOGY; PREDICTION; PROTEINS; MARKERS; STRESS
AB Aims: Endometriosis (EM) and metabolic disorders are frequent health problems among reproductive-aged women worldwide. Cardio-metabolic risk profile of women with EM is not well understood. We aimed to investigate the cardio-metabolic risk profile of Iranian reproductive-aged women with EM. Methods: This study included 976 female participants aged 20-45 years of Tehran Lipid and Glucose Study. Endometriosis was diagnosed based on the participants' self-reported previous diagnosis of EM, which was confirmed by reviewing the relevant medical documentation. All biochemical measures (low-density lipoprotein cholesterol [LDL], high-density lipoprotein cholesterol [HDL], triglycerides [TG], and fasting blood glucose concentrations [FBG]) and measurement of systolic blood pressure (SBP) and diastolic blood pressure (DBP) and anthropometric parameters were performed according to the standard protocol of TLGS. Logistic regression analysis was performed to estimate the odds ratio of cardio-metabolic disease. Results: Of the 976 study participants, 161 individuals (16.5%) had a confirmed diagnosis of endometriosis. There were no significant differences in the median of metabolic parameters among women with and without endometriosis (p > 0.05). The prevalence of metabolic syndrome was significantly higher in women with EM group compared to the non-EM group (21.9% vs. 14.9%). The presence of endometriosis was associated with an increased odds of metabolic syndrome (adjusted odds ratio 1.99 [95% CI 1.20-3.30]; p = 0.007). And endometriosis significantly increased odds of low HDL by 2.07 (1.02-4.20); after adjustment, it still remained significant (p = 0.03). Endometriosis also increased odds of high waist circumstance significantly (1.58 [1.06-2.37]; p = 0.02). Conclusions: Women with endometriosis may be at an increased risk of developing metabolic syndrome, high waist circumstance and low HDL compared to their counterparts without the condition. Given the potential cardio-metabolic implications, healthcare providers should consider assessing the metabolic profile of women diagnosed with endometriosis.
C1 [Naz, Marzieh Saei Ghare; Noroozzadeh, Mahsa; Ardebili, Shahla Noori; Mousavi, Maryam; Tehrani, Fahimeh Ramezani] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Reprod Endocrinol Res Ctr, Tehran, Iran.
   [Azizi, Fereidoun] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Res Ctr, Tehran, Iran.
   [Tehrani, Fahimeh Ramezani] Fdn Res & Educ Excellence, Vestavia Hills, AL 35266 USA.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences
RP Tehrani, FR (corresponding author), Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Reprod Endocrinol Res Ctr, Tehran, Iran.; Tehrani, FR (corresponding author), Fdn Res & Educ Excellence, Vestavia Hills, AL 35266 USA.
EM fah.tehrani@gmail.com
RI Azizi, Fereidoun/ABD-4136-2021; Noroozzadeh, Mahsa/K-4765-2017; Mousavi,
   Maryam/ACO-9731-2022; Tehrani, Fahimeh/H-6133-2017; Naz,
   Marzieh/K-8811-2019
OI Ramezani Tehrani, Fahimeh/0000-0002-4609-065X; Saei Ghare Naz,
   Marzieh/0000-0002-1259-2459
FU Research Institute for Endocrine Sciences, Shahid Beheshti University of
   Medical Sciences, Tehran, Iran [6-43011614]
FX This study funded by the Research Institute for Endocrine Sciences,
   Shahid Beheshti University of Medical Sciences, Tehran, Iran (Grant
   number: 6-43011614)
CR Agic A, 2006, GYNECOL OBSTET INVES, V62, P139, DOI 10.1159/000093121
   Ainsworth BE, 2000, MED SCI SPORT EXER, V32, pS498, DOI 10.1097/00005768-200009001-00009
   Amer Diabet Assoc, 2021, DIABETES CARE, V44, pS15, DOI 10.2337/dc21-S002
   Anastasi E, 2017, CLIN CHEM LAB MED, V55, pE282, DOI 10.1515/cclm-2017-0016
   Azizi F, 2010, ARCH IRAN MED, V13, P243
   Azizi F, 2009, TRIALS, V10, DOI 10.1186/1745-6215-10-5
   Becker CM, 2022, HUM REPROD OPEN, V2022, DOI 10.1093/hropen/hoac009
   Bedaiwy MA, 2002, HUM REPROD, V17, P426, DOI 10.1093/humrep/17.2.426
   Borisova AV, 2022, J MATERN-FETAL NEO M, V35, P2663, DOI 10.1080/14767058.2020.1793326
   Carrizales-Sánchez AK, 2021, GUT MICROBES, V13, DOI 10.1080/19490976.2021.1960135
   Catapano AL, 2017, BRIT J PHARMACOL, V174, P3973, DOI 10.1111/bph.13805
   Chang CYY, 2021, AM J EPIDEMIOL, V190, P277, DOI 10.1093/aje/kwaa173
   Chen LH, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24087503
   Cirillo M, 2022, HUM FERTIL, V25, P745, DOI 10.1080/14647273.2021.1919764
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Croci S, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051389
   do Couto CP, 2023, MATURITAS, V171, P45, DOI 10.1016/j.maturitas.2023.04.001
   Durrington P, 2003, LANCET, V362, P717, DOI 10.1016/S0140-6736(03)14234-1
   Engström G, 2007, ANN EPIDEMIOL, V17, P57, DOI 10.1016/j.annepidem.2006.03.005
   Esteve E, 2005, CLIN NUTR, V24, P16, DOI 10.1016/j.clnu.2004.08.004
   Farland LV, 2022, STROKE, V53, P3116, DOI 10.1161/STROKEAHA.122.039250
   Farland LV, 2021, DIABETOLOGIA, V64, P552, DOI 10.1007/s00125-020-05347-6
   Fatahi A, 2020, INT J PREVENTIVE MED, V11, DOI 10.4103/ijpvm.IJPVM_489_18
   Francesca B., 2014, BMJ Open, V4
   Franco C, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms232214489
   Rodríguez LAG, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016780
   Garus-Pakowska Anna, 2023, Int J Environ Res Public Health, V20, DOI 10.3390/ijerph20186789
   Gerhard GT, 1998, AM J CARDIOL, V82, P1040, DOI 10.1016/S0002-9149(98)00554-2
   Guo CS, 2024, FRONT MICROBIOL, V15, DOI 10.3389/fmicb.2024.1363455
   Gurung M, 2020, EBIOMEDICINE, V51, DOI 10.1016/j.ebiom.2019.11.051
   Han TS, 2016, JRSM CARDIOVASC DIS, V5, DOI 10.1177/2048004016633371
   Hantschel J, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0226835
   Hazar N, 2024, FRONT PUBLIC HEALTH, V12, DOI 10.3389/fpubh.2024.1322072
   KANNEL WB, 1969, DIS CHEST, V56, P43, DOI 10.1378/chest.56.1.43
   Kim JG, 2000, FERTIL STERIL, V73, P996, DOI 10.1016/S0015-0282(00)00493-3
   KOUMANTAKIS E, 1994, ARCH GYNECOL OBSTET, V255, P107, DOI 10.1007/BF02390936
   KRISKA AM, 1990, DIABETES CARE, V13, P401, DOI 10.2337/diacare.13.4.401
   Kvaskoff M, 2015, HUM REPROD UPDATE, V21, P500, DOI 10.1093/humupd/dmv013
   Lamceva J, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24054254
   Li BJ, 2023, GYNECOL ENDOCRINOL, V39, DOI 10.1080/09513590.2023.2254844
   Lu C, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25010029
   Melo AS, 2010, FERTIL STERIL, V93, P2433, DOI 10.1016/j.fertnstert.2009.08.043
   MonserratMesquida M., 2020, Antioxidants (Basel), V9, P1
   Moradi Y, 2021, INDIAN J MED RES, V154, P446, DOI 10.4103/ijmr.IJMR_817_18
   Mu F, 2018, AM J EPIDEMIOL, V187, P515, DOI 10.1093/aje/kwx272
   Mu F, 2017, HYPERTENSION, V70, P59, DOI 10.1161/HYPERTENSIONAHA.117.09056
   Mu F, 2016, CIRC-CARDIOVASC QUAL, V9, P257, DOI 10.1161/CIRCOUTCOMES.115.002224
   Nitsa A, 2018, IN VIVO, V32, P977, DOI 10.21873/invivo.11338
   Nnoaham KE, 2012, FERTIL STERIL, V98, P702, DOI 10.1016/j.fertnstert.2012.05.035
   Oala IE, 2024, DIAGNOSTICS, V14, DOI 10.3390/diagnostics14030312
   Ottolina J, 2020, REPROD BIOMED ONLINE, V41, P279, DOI 10.1016/j.rbmo.2020.04.005
   Parasar P, 2017, CURR OBSTET GYNECOL, V6, P34, DOI 10.1007/s13669-017-0187-1
   Parazzini F, 2017, EUR J OBSTET GYN R B, V209, P3, DOI 10.1016/j.ejogrb.2016.04.021
   Pouriamehr S, 2019, BMC RES NOTES, V12, DOI 10.1186/s13104-019-4492-9
   Ramezankhani A, 2022, BIOL SEX DIFFER, V13, DOI 10.1186/s13293-022-00421-7
   Ridker PM, 2002, NEW ENGL J MED, V347, P1557, DOI 10.1056/NEJMoa021993
   Ryan CG, 2014, EUR J PAIN, V18, P740, DOI 10.1002/j.1532-2149.2013.00405.x
   Shafrir AL, 2021, HUM REPROD, V36, P1268, DOI 10.1093/humrep/deab012
   Tehrani F. R., 2018, International Journal of Endocrinology and Metabolism, V16, P1
   Todowede OO, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2017-016602
   Turgut A, 2013, EUR REV MED PHARMACO, V17, P1472
   Turroni F, 2014, CELL MOL LIFE SCI, V71, P183, DOI 10.1007/s00018-013-1318-0
   van Hecke O, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0170653
   Vasquez EC, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/7092032
   Verit FF, 2008, HUM REPROD, V23, P100, DOI 10.1093/humrep/dem340
   Vona R, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8267234
   Wang PX, 2020, CHINESE MED J-PEKING, V133, P808, DOI 10.1097/CM9.0000000000000696
   Zhang Y, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.680833
   Zmora N, 2017, CELL METAB, V25, P506, DOI 10.1016/j.cmet.2017.02.006
NR 69
TC 1
Z9 1
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2398-9238
J9 ENDOCRIN DIAB METAB
JI Endocrinol. Diabetes Metab.
PD NOV
PY 2024
VL 7
IS 6
AR e70008
DI 10.1002/edm2.70008
PG 8
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA J0K3N
UT WOS:001334043800001
PM 39400459
OA gold
DA 2025-06-11
ER

PT J
AU Lejman-Larysz, K
   Golara, A
   Baranowska, M
   Kozlowski, M
   Guzik, P
   Szydlowska, I
   Nawrocka-Rutkowska, J
   Sowinska-Przepiera, E
   Cymbaluk-Ploska, A
   Brodowska, A
AF Lejman-Larysz, Katarzyna
   Golara, Anna
   Baranowska, Marta
   Kozlowski, Mateusz
   Guzik, Pawel
   Szydlowska, Iwona
   Nawrocka-Rutkowska, Jolanta
   Sowinska-Przepiera, Elzbieta
   Cymbaluk-Ploska, Aneta
   Brodowska, Agnieszka
TI Influence of Vitamin D on the Incidence of Metabolic Syndrome and
   Hormonal Balance in Patients with Polycystic Ovary Syndrome
SO NUTRIENTS
LA English
DT Article
DE vitamin D; polycystic ovary syndrome; metabolic syndrome;
   sex-hormone-binding globulin; prolactin; thyroid-stimulating hormone;
   androstendione; dehydroepiandrosterone sulfate; follicle-stimulating
   hormone; luteinizing hormone
ID 25-HYDROXYVITAMIN D LEVEL; D SUPPLEMENTATION; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; HYPOVITAMINOSIS D; WOMEN; METAANALYSIS;
   INFLAMMATION; SENSITIVITY; ASSOCIATION
AB Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder that affects 8-13% of women of reproductive age. It is one of the most common causes of infertility and is associated with hyperandrogenism in the form of hirsutism and acne, non-ovulatory cycles, and characteristic ovarian morphology. The available research on serum vitamin D deficiency in patients with PCOS and the appropriateness of vitamin D supplementation in this group of women is inconclusive, so we decided to investigate the influence of vitamin D on the incidence of metabolic syndrome and hormonal balance in patients with polycystic ovary syndrome. The study comprised 120 women aged between 18 and 42 years, who were divided into two groups: a group with diagnosed polycystic ovary syndrome (PCOS) and a group of regularly menstruating women without features of androgenisation, in whom polycystic ovary syndrome was excluded. Each patient underwent a history and physical examination, including a gynecological examination, anthropometric measurements were taken, including height, weight, waist, and hip circumference, and blood pressure was measured using the Korotkow method. In the female patients, the following parameters were also determined from the blood: follicle-stimulating hormone (FSH), luteinizing hormone (LH), oestradiol, TSH, ft4, prolactin (PRL), total testosterone, DHEASO4, 17-hydroxyprogesterone (17-OHP), sex-hormone-binding globulin (SHBG), androstendione, 25(OH) vitamin D3 metabolite. The majority of the patients with polycystic ovary syndrome were found to have deficient or suboptimal serum vitamin D levels, and the effects of vitamin D on the SHBG levels and free-androgen indices in these patients was examined. The effects of vitamin D on the incidence of metabolic syndrome and BMI, waist-to-hip ratio, waist circumference, and blood pressure in patients with polycystic ovary syndrome were also found.
C1 [Lejman-Larysz, Katarzyna; Szydlowska, Iwona; Nawrocka-Rutkowska, Jolanta; Brodowska, Agnieszka] Pomeranian Med Univ, Dept Gynecol Endocrinol & Gynecol Oncol, Unii Lubelskiej 1, PL-71252 Szczecin, Poland.
   [Golara, Anna; Baranowska, Marta; Kozlowski, Mateusz; Cymbaluk-Ploska, Aneta] Pomeranian Med Univ, Dept Reconstruct Surg & Gynecol Oncol, Al Powstancow Wielkopolskich 72, PL-70111 Szczecin, Poland.
   [Guzik, Pawel] City Hosp, Clin Dept Gynecol & Obstet, PL-35241 Rzeszow, Poland.
   [Sowinska-Przepiera, Elzbieta] Pomeranian Med Univ, Dept Endocrinol Metab & Internal Dis, Unii Lubelskiej 1, PL-71252 Szczecin, Poland.
C3 Pomeranian Medical University; Pomeranian Medical University; Pomeranian
   Medical University
RP Golara, A (corresponding author), Pomeranian Med Univ, Dept Reconstruct Surg & Gynecol Oncol, Al Powstancow Wielkopolskich 72, PL-70111 Szczecin, Poland.
EM kmlejman@gmail.com; anka39143@gmail.com; marciabaranowska2211@gmail.com;
   mtkoozo@gmail.com; pawelguzik@gmail.com; iwonaszyd@wp.pl;
   jolanaw@poczta.onet.pl; elzbieta.sowinska.przepiera@pum.edu.pl;
   aneta.cymbaluk@gmail.com; agabrod@wp.pl
RI Kozłowski, Mateusz/GLN-7723-2022; Agnieszka, Brodowska/B-1622-2018;
   Szydłowska, Iwona/AAA-6713-2022; Sowinska-Przepiera,
   Elzbieta/A-3367-2015
OI Nawrocka-Rutkowska, Jolanta/0000-0002-1631-152X; Golara,
   Anna/0000-0003-4300-4557; Brodowska, Agnieszka/0000-0002-6425-1648;
   Sowinska-Przepiera, Elzbieta/0000-0001-6693-9465; Kozlowski,
   Mateusz/0000-0002-1176-2153; Szydlowska, Iwona/0000-0003-1518-8838
CR Adorini L, 2008, NAT CLIN PRACT RHEUM, V4, P404, DOI 10.1038/ncprheum0855
   Akbari M, 2018, HORM METAB RES, V50, P271, DOI 10.1055/s-0044-101355
   [Anonymous], 2021, Vitamin D
   Autier P, 2007, ARCH INTERN MED, V167, P1730, DOI 10.1001/archinte.167.16.1730
   Blum M, 2008, ENDOCRINE, V33, P90, DOI 10.1007/s12020-008-9051-4
   Deleskog A, 2012, DIABETOLOGIA, V55, P1668, DOI 10.1007/s00125-012-2529-x
   Ford ES, 2005, DIABETES CARE, V28, P1228, DOI 10.2337/diacare.28.5.1228
   Ginde AA, 2009, ARCH INTERN MED, V169, P384, DOI 10.1001/archinternmed.2008.560
   Hahn S, 2006, EXP CLIN ENDOCR DIAB, V114, P577, DOI 10.1055/s-2006-948308
   He CL, 2015, NUTRIENTS, V7, P4555, DOI 10.3390/nu7064555
   Krentowska A, 2021, ENDOCRINE, V72, P400, DOI 10.1007/s12020-020-02596-8
   Krul-Poel YHM, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0204748
   Li YC, 2002, J CLIN INVEST, V110, P229, DOI [10.1172/JCI200215219, 10.1172/JCI0215219]
   LIND L, 1989, DIABETES RES CLIN EX, V11, P141
   Mansournia MA, 2018, HORM METAB RES, V50, P429, DOI 10.1055/a-0630-1303
   Mishra S, 2016, J CLIN DIAGN RES, V10, pBC1, DOI 10.7860/JCDR/2016/19407.7771
   Muscogiuri G, 2012, CLIN NUTR, V31, P476, DOI 10.1016/j.clnu.2011.12.010
   Nazarian S, 2011, TRANSL RES, V158, P276, DOI 10.1016/j.trsl.2011.05.002
   Panidis D, 2005, CLIN CHEM, V51, P1691, DOI 10.1373/clinchem.2005.052761
   Pludowski P, 2016, POL ARCH MED WEWN, V126, P530, DOI 10.20452/pamw.3479
   ROMANOWSKI Mariana Drechmer, 2015, Arq. Gastroenterol., V52, P117, DOI 10.1590/S0004-28032015000200008
   Savastano S, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-84
   Tsakova AD, 2012, INT J VITAM NUTR RES, V82, P399, DOI 10.1024/0300-9831/a000137
   Walsh JS, 2017, CURR OPIN ENDOCRINOL, V24, P389, DOI 10.1097/MED.0000000000000371
   Wehr E, 2009, EUR J ENDOCRINOL, V161, P575, DOI 10.1530/EJE-09-0432
   Zhao JF, 2021, ANN PALLIAT MED, V10, P169, DOI 10.21037/apm-20-2201
NR 26
TC 8
Z9 8
U1 3
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2023
VL 15
IS 13
AR 2952
DI 10.3390/nu15132952
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA M2FA8
UT WOS:001028379700001
PM 37447279
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hristova, M
   Aloe, L
AF Hristova, M
   Aloe, L
TI Metabolic syndrome - Neurotrophic hypothesis
SO MEDICAL HYPOTHESES
LA English
DT Article
ID NERVE GROWTH-FACTOR; PITUITARY-ADRENAL AXIS; INSULIN-RESISTANCE;
   BLOOD-PRESSURE; BRAIN; BEHAVIOR; OBESITY; LEPTIN; GLAND
AB An increasing number of researchers of the metabolic syndrome assume that many mechanisms are involved in its complex pathophysiology such as an increased sympathetic activity, disorders of the hypothalamo-pituitary-adrenal axis, the action of chronic subclinical infections, proinflammatory cytokines, and the effect of adipocytokines or psychoemotional stress. An increasing body of scientific research in this field confirms the role of the neurotrophins and mastocytes in the pathogenesis of inflammatory and immune diseases. Recently it has been proved that neurotrophins and mastocytes have metabotrophic effects and take part in the carbohydrate and lipid metabolism.
   In the early stage of the metabolic syndrome we established a statistically significant increase in the plasma levels of the nerve growth factor. In the generalized stage the plasma levels of the neutrophines were statistically decreased in comparison to those in the healthy controls.
   We consider that the neurotrophin deficit is likely to play a significant pathogenic rote in the development of the metabolic anthropometric and vascular manifestations of the generalized stage of MetSyn.
   We suggest a hypothesis for the etiopathogenesis of the metabolic syndrome based on the neuro-immuno-endocrine interactions.
   The specific pathogenic pathways of MetSyn development include: (1) increased tissue and plasma levels of proinflammatory cytokines Interleukin-1 (IL-1), Interleukin-6 (IL-6) and tumor necrosis factor - alpha (TNF-alpha) caused by inflammatory and/or emotional distress; (2) increased plasma levels of neurotrophin - nerve growth factor (NGF) caused by the high IL-1, IL-6 and TNF alpha levels; (3) high plasma levels of NGF which enhance activation of: the autonomous nerve system - vegetodystonia (disbalance of neurotransmitters); Neuropeptide Y (NPY) - enhanced feeding, obesity and increased leptin plasma levels; hypothalamo-pituitary-adrenal axis - increased corticotropin-releasing hormone (CRH) and cortisol (hormonal disbalance); immune cells - increased number and degranulation of mastocytes (MC) - immunological disbalance; (4) as a result of 1-3 insulin resistance is exhibited leading to diabetes mellitus.
   The hypothesis is confirmed by results obtained after 6-month nonsteroid anti-inflammatory treatment of patients with MetSyn. These results are reported in a separate publication. (c) 2005 Elsevier Ltd. All rights reserved.
C1 Varna Univ Med, Dept Endocrinol, BG-9003 Varna, Bulgaria.
   Inst Neurobiol & Mol Med, Rome, Italy.
C3 Medical University Varna
RP Varna Univ Med, Dept Endocrinol, 17 Mur St,Entr 2, BG-9003 Varna, Bulgaria.
EM library@io-bas.bg
CR Alleva E, 1993, Rev Neurosci, V4, P41
   Aloe L, 1999, MICROSC RES TECHNIQ, V45, P285, DOI 10.1002/(SICI)1097-0029(19990515/01)45:4/5<285::AID-JEMT12>3.0.CO;2-3
   ALOE L, 1994, AUTOIMMUNITY, V19, P141, DOI 10.3109/08916939409009542
   ALOE L, 1986, P NATL ACAD SCI USA, V83, P6184, DOI 10.1073/pnas.83.16.6184
   ALOE L, 1994, P NATL ACAD SCI USA, V91, P10440, DOI 10.1073/pnas.91.22.10440
   Aloe L, 2001, CURR PHARM DESIGN, V7, P113, DOI 10.2174/1381612013398383
   ALOE L, 1998, BIOMED REV, V9, P93
   BESEDOVSKY H, 1996, AM J ENDOCRIN METAB, V17, P64
   Björntorp P, 1999, DIABETIC MED, V16, P373, DOI 10.1046/j.1464-5491.1999.00067.x
   BLALOCK JE, 1994, IMMUNOL TODAY, V15, P504, DOI 10.1016/0167-5699(94)90205-4
   Chaldakov G N, 2001, Arch Physiol Biochem, V109, P357, DOI 10.1076/apab.109.3.357.9353
   Chaldakov George N, 2003, Med Sci Monit, V9, pHY19
   Fiore M, 1997, NEUROSCI LETT, V223, P161, DOI 10.1016/S0304-3940(97)13425-5
   Fiore M, 1999, BEHAV BRAIN RES, V101, P85, DOI 10.1016/S0166-4328(98)00143-0
   Funahashi T, 1999, INTERNAL MED, V38, P202, DOI 10.2169/internalmedicine.38.202
   Grimble RF, 2002, CURR OPIN CLIN NUTR, V5, P551, DOI 10.1097/00075197-200209000-00015
   HATANAKA K, 1986, BIOCHIM BIOPHYS ACTA, V878, P440, DOI 10.1016/0005-2760(86)90254-7
   Hiriart M, 2001, ISRAEL MED ASSOC J, V3, P114
   JULIUS S, 2000, SNS REPORT, V1, P2
   Kondo H, 2002, DIABETES, V51, P2325, DOI 10.2337/diabetes.51.7.2325
   MATHISON R, 1994, IMMUNOL TODAY, V15, P527, DOI 10.1016/0167-5699(94)90209-7
   Nisoli E, 1996, ENDOCRINOLOGY, V137, P495, DOI 10.1210/en.137.2.495
   Nisoli E, 1996, NAT MED, V2, P130, DOI 10.1038/nm0296-130
   Pennisi E, 1997, SCIENCE, V275, P930, DOI 10.1126/science.275.5302.930
   Rosmond R, 1998, J HYPERTENS, V16, P1721, DOI 10.1097/00004872-199816120-00003
   Rosmond R, 1998, INT J OBESITY, V22, P1184, DOI 10.1038/sj.ijo.0800745
   SHINTANI F, 1998, NEUROBIOLOGY, V10, P47
   Van den Berghe G, 1998, J CLIN ENDOCR METAB, V83, P1827, DOI 10.1210/jc.83.6.1827
   Woiciechowsky C, 1999, J MOL MED-JMM, V77, P769, DOI 10.1007/s001099900051
   Yudkin JS, 2000, ATHEROSCLEROSIS, V148, P209, DOI 10.1016/S0021-9150(99)00463-3
   Zakrzewska KE, 1997, DIABETES, V46, P717, DOI 10.2337/diabetes.46.4.717
NR 31
TC 73
Z9 80
U1 0
U2 5
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PY 2006
VL 66
IS 3
BP 545
EP 549
DI 10.1016/j.mehy.2005.08.055
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 026EF
UT WOS:000236319200018
PM 16298496
DA 2025-06-11
ER

PT J
AU Çakit, O
   Gümüstepe, A
   Çakit, BD
   Vural, SP
   Özgün, T
   Genç, H
AF Cakit, Onat
   Gumustepe, Alper
   Cakit, Burcu Duyur
   Vural, Secil Pervane
   Ozgun, Tuba
   Genc, Hakan
TI Coexistence of fibromyalgia and metabolic syndrome in females: The
   effects on fatigue, clinical features, pain sensitivity, urinary
   cortisol and norepinephrine levels: A cross-sectional study
SO ARCHIVES OF RHEUMATOLOGY
LA English
DT Article
DE Fibromyalgia; metabolic syndrome; obesity; pain pressure threshold
ID INSULIN-RESISTANCE; HYPOTHALAMIC-PITUITARY; RISK-FACTORS; HEART-RATE;
   POPULATION; OBESITY; CATECHOLAMINES; ASSOCIATION; PREVALENCE; PLASMA
AB Objectives: This study aims to evaluate the coexistence of metabolic syndrome (MetS) and fibromyalgia syndrome (FMS) and determine the effects of this coexistence on neuroendocrine levels and clinical features of FMS.
   Patients and methods: One-hundred female FMS patients (mean age: 40.1 +/- 7.8 years; range, 24 to 58 years) and 38 healthy females (mean age: 40.4 +/- 5.8 years; range, 30 to 55 years) were included in this cross-sectional study. MetS was identified by using the criteria from the Adult Treatment Panel III. Widespread pain index, symptom severity score and number of tender points were determined. Visual analog scale, Fibromyalgia Impact Questionnaire, Fatigue Severity Scale, Beck Depression Inventory, and pain pressure threshold were used as the outcome measures. The severity of FMS was assessed with total myalgic score (TMS) and control point score.
   Results: Twenty-four (24%) of the 100 FMS patients and three (7.9%) of the 38 control patients fulfilled the MetS criteria (p=0.047). The coexistence of FMS and MetS was associated with higher symptom severity score (p=0.004), widespread pain index (p=0.001), number of tender points (p=0.039), and lower total myalgic score (p=0.029) values. There was a significant association between the occurrence of FMS and MetS (odds ratio=3.76; 95% confidence interval: 1.04-13.4; p=0.043).
   Conclusion: We found that patients with FMS had a nearly four times higher risk for MetS and the coexisting MetS may increase the severity of FMS. In clinical practice, when evaluating a patient with FMS, metabolic characteristics should also be evaluated.
C1 [Cakit, Onat] Univ Hlth Sci, Ankara Training & Res Hosp, Dept Family Med, Ankara, Turkey.
   [Gumustepe, Alper] Kahramankazan Goverment Hosp, Dept Phys Med & Rehabil, Ankara, Turkey.
   [Cakit, Burcu Duyur; Vural, Secil Pervane; Genc, Hakan] Univ Hlth Sci, Ankara Training & Res Hosp, Dept Phys Med & Rehabil, Ankara, Turkey.
   [Ozgun, Tuba] Univ Hlth Sci, Ankara Training & Res Hosp, Dept Biochem, Ankara, Turkey.
C3 Ankara Training & Research Hospital; University of Health Sciences
   Turkey; University of Health Sciences Turkey; Ankara Training & Research
   Hospital; University of Health Sciences Turkey; Ankara Training &
   Research Hospital
RP Vural, SP (corresponding author), Ankara Egitim Arastirma Hastanesi, Fiz Tedavi Rehabil Klin, TR-06230 Ankara, Turkey.
EM secilvural@hotmail.com
RI duyur cakit, burcu/HJA-0112-2022; Cakit, Mehmet Onat/HNQ-2984-2023;
   Genc, Hakan/CAA-4799-2022
OI Cakit, Mehmet Onat/0000-0002-6880-4633; Genc, Hakan/0000-0003-2573-4564
CR Adler GK, 1999, AM J MED, V106, P534, DOI 10.1016/S0002-9343(99)00074-1
   Andersson HI, 2009, DISABIL REHABIL, V31, P1980, DOI 10.3109/09638280902874154
   [Anonymous], 2006, OB OV
   Arendt-Nielsen Lars, 2003, Curr Pain Headache Rep, V7, P355, DOI 10.1007/s11916-003-0034-0
   BECK AT, 1984, J CLIN PSYCHOL, V40, P1365, DOI 10.1002/1097-4679(198411)40:6<1365::AID-JCLP2270400615>3.0.CO;2-D
   BECK AT, 1988, CLIN PSYCHOL REV, V8, P77, DOI 10.1016/0272-7358(88)90050-5
   Becker S, 2012, PAIN RES TREAT, V2012, DOI 10.1155/2012/741746
   Blake GJ, 2004, ARCH INTERN MED, V164, P757, DOI 10.1001/archinte.164.7.757
   Bonora E, 1998, DIABETES, V47, P1643, DOI 10.2337/diabetes.47.10.1643
   Bray GA, 2006, ENDOCRINE, V29, P109, DOI 10.1385/ENDO:29:1:109
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   Corry D B, 1999, Curr Hypertens Rep, V1, P119, DOI 10.1007/s11906-999-0005-x
   Demitrack MA, 1998, ANN NY ACAD SCI, V840, P684, DOI 10.1111/j.1749-6632.1998.tb09607.x
   Egeland GM, 2016, OBESITY, V24, P1162, DOI 10.1002/oby.21452
   Fava A, 2013, METAB BRAIN DIS, V28, P619, DOI 10.1007/s11011-013-9421-3
   Fava M, 2000, J CLIN PSYCHIAT, V61, P37
   Fischer A.A., 1987, the Clinical journal of pain, V3, P23, DOI DOI 10.1097/00002508-198703010-00005
   Fries E, 2005, PSYCHONEUROENDOCRINO, V30, P1010, DOI 10.1016/j.psyneuen.2005.04.006
   Gencay-Can A, 2012, RHEUMATOL INT, V32, P27, DOI 10.1007/s00296-010-1558-3
   GOLDEN RN, 1988, ARCH GEN PSYCHIAT, V45, P150
   Goodson NJ, 2013, PAIN, V154, P1595, DOI 10.1016/j.pain.2013.04.043
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   HENRIKSSON CM, 1994, SCAND J RHEUMATOL, V23, P36, DOI 10.3109/03009749409102133
   LAWS A, 1993, BAILLIERE CLIN ENDOC, V7, P1063, DOI 10.1016/S0950-351X(05)80245-9
   Loevinger BL, 2007, METABOLISM, V56, P87, DOI 10.1016/j.metabol.2006.09.001
   Loevinger BL, 2012, CLIN RHEUMATOL, V31, P677, DOI 10.1007/s10067-011-1912-1
   Martínez-Lavín M, 2000, SEMIN ARTHRITIS RHEU, V29, P197, DOI 10.1016/S0049-0172(00)80008-6
   Martinez-Lavin M, 2007, ARTHRITIS RES THER, V9, DOI 10.1186/ar2146
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Nilsson Peter M., 1997, Blood Pressure, V6, P294, DOI 10.3109/08037059709062085
   Okifuji A, 2010, J PAIN, V11, P1329, DOI 10.1016/j.jpain.2010.03.006
   Okifuji A, 2009, CLIN RHEUMATOL, V28, P475, DOI 10.1007/s10067-009-1094-2
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Ray L, 2011, PAIN, V152, P53, DOI 10.1016/j.pain.2010.08.043
   Riva R, 2012, J PSYCHOSOM RES, V72, P51, DOI 10.1016/j.jpsychores.2011.09.010
   Sarmer S, 2000, RHEUMATOL INT, V20, P9, DOI 10.1007/s002960000077
   Stein PK, 2004, ARTHRIT RHEUM-ARTHR, V51, P700, DOI 10.1002/art.20687
   Trevisol DJ, 2011, J HYPERTENS, V29, P179, DOI 10.1097/HJH.0b013e328340d76f
   Ursini F, 2011, RHEUMATOL INT, V31, P1403, DOI 10.1007/s00296-011-1885-z
   Wallace DJ, 2006, CURR PHARM DESIGN, V12, P17, DOI 10.2174/138161206775193208
   WHO Consultation, 2000, WHO TECH REP SER, V894, P1
   Wilson JF, 2005, ANN INTERN MED, V142, P877, DOI 10.7326/0003-4819-142-10-200505170-00026
   Wolfe F, 2010, ARTHRIT CARE RES, V62, P600, DOI 10.1002/acr.20140
   Yanmaz MN, 2012, RHEUMATOL INT, V32, P871, DOI 10.1007/s00296-010-1618-8
   YUNUS MB, 1992, J RHEUMATOL, V19, P95
NR 45
TC 11
Z9 11
U1 0
U2 6
PU TURKISH LEAGUE AGAINST RHEUMATISM
PI ANKARA
PA TALATPASA BULVARI DUMLUPINAR CAD 40 3 CEBECI DORTYOL, ANKARA, 06100,
   TURKEY
EI 2618-6500
J9 ARCH RHEUMATOL
JI Arch. Rheumatol.
PD MAR
PY 2021
VL 36
IS 1
BP 26
EP 37
DI 10.46497/ArchRheumatol.2021.7534
PG 12
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA QP0KO
UT WOS:000623526400004
PM 34046566
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Li, QK
   Yin, WD
   Cai, MB
   Liu, Y
   Hou, HJ
   Shen, QY
   Zhang, C
   Xiao, JX
   Hu, XB
   Wu, QSS
   Funaki, M
   Nakaya, Y
AF Li, Qinkai
   Yin, Weidong
   Cai, Manbo
   Liu, Yi
   Hou, Hongjie
   Shen, Qingyun
   Zhang, Chi
   Xiao, Junxia
   Hu, Xiaobo
   Wu, Qishisan
   Funaki, Makoto
   Nakaya, Yutaka
TI NO-1886 suppresses diet-induced insulin resistance and cholesterol
   accumulation through STAT5-dependent upregulation of IGF1 and CYP7A1
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID GROWTH-FACTOR-I; DENSITY-LIPOPROTEIN CHOLESTEROL; ACTIVATED
   RECEPTOR-ALPHA; BILE-ACID SYNTHESIS; GENE-TRANSCRIPTION;
   7-ALPHA-HYDROXYLASE GENE; METABOLIC-SYNDROME; DIABETES-MELLITUS; NUCLEAR
   RECEPTORS; LIPASE ACTIVITY
AB Insulin resistance and dyslipidemia are both considered to be risk factors for metabolic syndrome. Low levels of IGF1 are associated with insulin resistance. Elevation of low-density lipoprotein cholesterol (LDL-C) concomitant with depression of high-density lipoprotein cholesterol (HDL-C) increase the risk of obesity and type 2 diabetes mellitus (T2DM). Liver secretes IGF1 and catabolizes cholesterol regulated by the rate-limiting enzyme of bile acid synthesis from cholesterol 7 alpha-hydroxylase (CYP7A1). NO-1886, a chemically synthesized lipoprotein lipase activator, suppresses diet-induced insulin resistance with the improvement of HDL-C. The goal of the present study is to evaluate whether NO-1886 upregulates IGF1 and CYP7A1 to benefit glucose and cholesterol metabolism. By using human hepatoma cell lines (HepG2 cells) as an in vitro model, we found that NO-1886 promoted IGF1 secretion and CYP7A1 expression through the activation of signal transducer and activator of transcription 5 (STAT5). Pretreatment of cells with AG 490, the inhibitor of STAT pathway, completely abolished NO1886-induced IGF1 secretion and CYP7A1 expression. Studies performed in Chinese Bama minipigs pointed out an augmentation of plasma IGF1 elicited by a single dose administration of NO-1886. Long-term supplementation with NO-1886 recovered hyperinsulinemia and low plasma levels of IGF1 suppressed LDL-C and facilitated reverse cholesterol transport by decreasing hepatic cholesterol accumulation through increasing CYP7A1 expression in high-fat/high-sucrose/high-cholesterol diet minipigs. These findings indicate that NO-1886 upregulates IGF1 secretion and CYP7A1 expression to improve insulin resistance and hepatic cholesterol accumulation, which may represent an alternative therapeutic avenue of NO-1886 for T2DM and metabolic syndrome. Journal of Endocrinology (2010) 204, 47-56
C1 [Li, Qinkai; Yin, Weidong; Cai, Manbo; Liu, Yi; Hou, Hongjie; Shen, Qingyun; Zhang, Chi; Xiao, Junxia; Hu, Xiaobo] Univ S China, Life Sci Res Ctr, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.
   [Li, Qinkai; Wu, Qishisan; Nakaya, Yutaka] Univ Tokushima, Grad Sch, Inst Hlth Biosci, Dept Nutr & Metab, Tokushima 7708503, Japan.
   [Li, Qinkai; Funaki, Makoto] Tokushima Univ Hosp, Clin Res Ctr Diabet, Tokushima 7708503, Japan.
C3 University of South China; Tokushima University; Tokushima University
RP Yin, WD (corresponding author), Univ S China, Life Sci Res Ctr, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.
EM wdy20042004@126.com
RI Hu, xiaobo/LVR-4333-2024
FU Project 973 of China [G2000056905]; National Natural Sciences Foundation
   of China [30370675, 30470720]
FX The research was supported in part from Project 973 of China G2000056905
   and the National Natural Sciences Foundation of China (project 30370675
   and 30470720).
CR Bellinger DA, 2006, ILAR J, V47, P243, DOI 10.1093/ilar.47.3.243
   BROWN MS, 1986, SCIENCE, V232, P34, DOI 10.1126/science.3513311
   Brownlee M, 2005, DIABETES, V54, P1615, DOI 10.2337/diabetes.54.6.1615
   Chawla A, 2000, CELL, V103, P1, DOI 10.1016/S0092-8674(00)00097-0
   Chia DJ, 2006, J BIOL CHEM, V281, P3190, DOI 10.1074/jbc.M510204200
   Chiang John Y. L., 1998, Frontiers in Bioscience, V3, pD176
   Chiang JYL, 2001, GENE, V262, P257, DOI 10.1016/S0378-1119(00)00518-7
   Clark RG, 1997, ENDOCRINOLOGY, V138, P4316, DOI 10.1210/en.138.10.4316
   Davey HW, 2001, ENDOCRINOLOGY, V142, P3836, DOI 10.1210/en.142.9.3836
   DEFRONZO RA, 1991, DIABETES CARE, V14, P173, DOI 10.2337/diacare.14.3.173
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   FIELDING CJ, 1995, J LIPID RES, V36, P211
   Froesch ER, 1996, DIABETES METAB REV, V12, P195, DOI 10.1002/(SICI)1099-0895(199610)12:3<195::AID-DMR164>3.0.CO;2-G
   Frost RA, 2002, ENDOCRINOLOGY, V143, P492, DOI 10.1210/en.143.2.492
   Goldberg IJ, 1996, J LIPID RES, V37, P693
   Goodwin B, 2003, MOL ENDOCRINOL, V17, P386, DOI 10.1210/me.2002-0246
   HORTON JD, 1995, J BIOL CHEM, V270, P5381, DOI 10.1074/jbc.270.10.5381
   JAVITT NB, 1994, FASEB J, V8, P1308, DOI 10.1096/fasebj.8.15.8001744
   Kajstura J, 2001, DIABETES, V50, P1414, DOI 10.2337/diabetes.50.6.1414
   LAEMMLI UK, 1970, NATURE, V227, P680, DOI 10.1038/227680a0
   Lu TT, 2000, MOL CELL, V6, P507, DOI 10.1016/S1097-2765(00)00050-2
   MASSA G, 1993, DIABETOLOGIA, V36, P239, DOI 10.1007/BF00399957
   Meydan N, 1996, NATURE, V379, P645, DOI 10.1038/379645a0
   Miquet JG, 2004, ENDOCRINOLOGY, V145, P2824, DOI 10.1210/en.2003-1498
   Moller DE, 2005, ANNU REV MED, V56, P45, DOI 10.1146/annurev.med.56.082103.104751
   MOLLER DE, 1991, NEW ENGL J MED, V325, P938
   MYANT NB, 1977, J LIPID RES, V18, P135
   Niho N, 2005, P NATL ACAD SCI USA, V102, P2970, DOI 10.1073/pnas.0500153102
   Onishi M, 1998, MOL CELL BIOL, V18, P3871, DOI 10.1128/MCB.18.7.3871
   Osada R, 1996, J ORTHOP RES, V14, P690, DOI 10.1002/jor.1100140503
   Pandak WM, 1996, AM J PHYSIOL-GASTR L, V270, pG401, DOI 10.1152/ajpgi.1996.270.3.G401
   Pandak WM, 2001, AM J PHYSIOL-GASTR L, V281, pG878, DOI 10.1152/ajpgi.2001.281.4.G878
   Patel DD, 2000, BIOCHEM J, V351, P747, DOI 10.1042/0264-6021:3510747
   Ratliff EP, 2006, J LIPID RES, V47, P1513, DOI 10.1194/jlr.M600120-JLR200
   Repa JJ, 2000, ANNU REV CELL DEV BI, V16, P459, DOI 10.1146/annurev.cellbio.16.1.459
   SPADY DK, 1995, J CLIN INVEST, V96, P700, DOI 10.1172/JCI118113
   Takano T, 2001, MOL CELL BIOL, V21, P5050, DOI 10.1128/MCB.21.15.5050-5062.2001
   Trigatti B, 2000, CURR OPIN LIPIDOL, V11, P123, DOI 10.1097/00041433-200004000-00004
   Tsutsumi K, 1997, METABOLISM, V46, P257, DOI 10.1016/S0026-0495(97)90250-X
   TSUTSUMI K, 1993, J CLIN INVEST, V92, P411, DOI 10.1172/JCI116582
   TURLEY SD, 1988, LIVER BIOL PATHOBIOL
   Vidal OM, 2007, MOL ENDOCRINOL, V21, P293, DOI 10.1210/me.2006-0096
   Woelfle J, 2004, AM J PHYSIOL-ENDOC M, V286, pE393, DOI 10.1152/ajpendo.00389.2003
   Woelfle J, 2003, J BIOL CHEM, V278, P22696, DOI 10.1074/jbc.M301362200
   Xi SM, 2004, INT J EXP PATHOL, V85, P223, DOI 10.1111/j.0959-9673.2004.00394.x
   Yakar S, 2001, DIABETES, V50, P1110, DOI 10.2337/diabetes.50.5.1110
   Yin W, 2004, J ENDOCRINOL, V180, P399, DOI 10.1677/joe.0.1800399
   Yin WD, 2004, PHARMACOL RES, V49, P199, DOI 10.1016/j.phrs.2003.09.008
   Yin Weidong, 2003, Int J Exp Diabesity Res, V4, P27
   Yu J, 2007, BIOCHEM BIOPH RES CO, V356, P53, DOI 10.1016/j.bbrc.2007.02.129
   Zhang C, 2006, J LIPID RES, V47, P2055, DOI 10.1194/jlr.M600226-JLR200
   Zhou YC, 1999, J BIOL CHEM, V274, P29874, DOI 10.1074/jbc.274.42.29874
NR 52
TC 15
Z9 18
U1 0
U2 9
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD JAN
PY 2010
VL 204
IS 1
BP 47
EP 56
DI 10.1677/JOE-09-0278
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 568MW
UT WOS:000275527500006
PM 19815588
OA Bronze
DA 2025-06-11
ER

PT J
AU Franklin, C
   Stoffels-Weindorf, M
   Hillen, U
   Dissemond, J
AF Franklin, Cindy
   Stoffels-Weindorf, Maren
   Hillen, Uwe
   Dissemond, Joachim
TI Ulcerated necrobiosis lipoidica as a rare cause for chronic leg ulcers:
   case report series of ten patients
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Chronic wound; Diabetes mellitus; Leg ulcer; Metabolic syndrome;
   Necrobiosis lipoidica
ID SQUAMOUS-CELL CARCINOMA; FUMARIC-ACID ESTERS; SIGNIFICANT IMPROVEMENT;
   INFLAMMATORY DISEASES; VENOUS INSUFFICIENCY; DIMETHYLFUMARATE;
   DIABETICORUM; MULTICENTER; THERAPY
AB Necrobiosis lipoidica is a rare granulomatous disorder of the skin. In up to 30% of the affected patients it can lead to ulcerations, which can impair the quality of life and are also very difficult to treat. Its pathogenesis is not fully understood. Only few studies focussing on necrobiosis lipoidica can be found, but none of them focus on ulcerated necrobiosis lipoidica. Therefore, we collected demographic data and comorbidities and assessed treatment options for patients with ulcerated necrobiosis lipoidica. Data of patients who were treated in the wound care centre of the University Hospital of Essen for ulcerated necrobiosis lipoidica over the past 10 years were retrospectively analysed. Hence, data of altogether ten patients (nine women and one man) with ulcerated necrobiosis lipoidica were collected. Of these, 70% of the patients had diabetes mellitus of which 30% had type I diabetes and 40% had type II diabetes; 60% of the patients suffered from arterial hypertension, obesity and hypercholesterolaemia; 40% of the patients suffered from psychiatric disorders such as depression and borderline disorder. Our clinical data demonstrate an association of ulcerated necrobiosis lipoidica and aspects of metabolic syndrome. This leads to a conclusion that ulcerating necrobiosis lipoidica can be seen as part of a generalised inflammatory reaction similar to the inflammatory reaction already known in the pathophysiology of rheumatoid diseases or psoriasis. In patients with clinical atypical painful ulcerations, necrobiosis lipoidica should be considered as a possible differential diagnosis. Therapists should be aware of associated aspects in patients with ulcerated necrobiosis lipoidica who besides diabetes often suffer from other aspects of a metabolic syndrome with increased cardiovascular risk factors. Therefore, these related comorbidities should also be diagnosed and treated.
C1 [Franklin, Cindy; Stoffels-Weindorf, Maren; Hillen, Uwe; Dissemond, Joachim] Univ Duisburg Essen, Dept Dermatol Venereol & Allergol, Univ Hosp Essen, D-45177 Essen, Germany.
C3 University of Duisburg Essen
RP Dissemond, J (corresponding author), Univ Essen Gesamthsch, Dept Dermatol Venereol & Allergol, Hufelandstr 55, D-45177 Essen, Germany.
EM joachim.dissemond@uk-essen.de
RI Franklin, Cindy/AAU-4915-2021; Dissemond, Joachim/AFG-0691-2022
CR Aslan E, 2007, HAUTARZT, V58, P684, DOI 10.1007/s00105-006-1282-9
   Barth D, 2011, HAUTARZT, V62, P459, DOI 10.1007/s00105-010-2058-9
   Batchelor JM, 2012, J DRUGS DERMATOL, V11, P256
   Beattie PE, 2006, CLIN EXP DERMATOL, V31, P235, DOI 10.1111/j.1365-2230.2005.02059.x
   Berking C, 2009, DERMATOLOGY, V218, P136, DOI 10.1159/000182259
   Clayton TH, 2005, BRIT J DERMATOL, V152, P581, DOI 10.1111/j.1365-2133.2005.06388.x
   CLEMENT M, 1985, ARCH DERMATOL, V121, P24, DOI 10.1001/archderm.121.1.24
   Conte H, 2011, ACTA DERM-VENEREOL, V91, P587, DOI 10.2340/00015555-1117
   Crowson AN, 2003, HUM PATHOL, V34, P1185, DOI 10.1016/S0046-8177(03)00428-3
   Davidovici BB, 2010, J INVEST DERMATOL, V130, P1785, DOI 10.1038/jid.2010.103
   de Souza FHD, 2011, AN BRAS DERMATOL, V86, P1007
   De Rie MA, 2002, BRIT J DERMATOL, V147, P743, DOI 10.1046/j.1365-2133.2002.04856.x
   Eberle FC, 2010, ACTA DERM-VENEREOL, V90, P104, DOI 10.2340/00015555-0757
   Erfurt-Berge C, 2012, EUR J DERMATOL, V22, P770, DOI 10.1684/ejd.2012.1839
   Ghoreschi Kamran, 2004, Current Drug Targets - Inflammation and Allergy, V3, P193, DOI 10.2174/1568010043343949
   Guedes R, 2012, CASE REP MED, V2012, DOI 10.1155/2012/854738
   Huptas L, 2011, HAUTARZT, V62, P280, DOI 10.1007/s00105-011-2141-x
   Imtiaz KE, 2001, DIABETIC MED, V18, P325, DOI 10.1046/j.1464-5491.2001.00452.x
   Kavala M, 2010, INT J DERMATOL, V49, P467, DOI 10.1111/j.1365-4632.2010.04149.x
   Körber A, 2011, J DTSCH DERMATOL GES, V9, P116, DOI 10.1111/j.1610-0387.2010.07535.x
   Kolde G, 2003, DERMATOLOGY, V206, P180, DOI 10.1159/000068465
   Kreuter A, 2005, BRIT J DERMATOL, V153, P802, DOI 10.1111/j.1365-2133.2005.06762.x
   Litjens NHR, 2004, EUR J IMMUNOL, V34, P565, DOI 10.1002/eji.200324174
   Loewe R, 2002, J IMMUNOL, V168, P4781, DOI 10.4049/jimmunol.168.9.4781
   LOWITT MH, 1991, J AM ACAD DERMATOL, V25, P735, DOI 10.1016/S0190-9622(08)80961-9
   Mahé E, 2011, ANN DERMATOL VENER, V138, P686, DOI 10.1016/j.annder.2011.02.013
   Mitoma H, 2008, ARTHRITIS RHEUM-US, V58, P1248, DOI 10.1002/art.23447
   Müller-Ladner U, 2009, DEUT MED WOCHENSCHR, V134, P2132, DOI 10.1055/s-0029-1242011
   MULLER SA, 1966, ARCH DERMATOL, V93, P272, DOI 10.1001/archderm.93.3.272
   Nakajima T, 2009, J DERMATOL, V36, P166, DOI 10.1111/j.1346-8138.2009.00612.x
   Ngo B, 2008, INT J DERMATOL, V47, P354, DOI 10.1111/j.1365-4632.2008.03549.x
   NOZ KC, 1993, CLIN EXP DERMATOL, V18, P78, DOI 10.1111/j.1365-2230.1993.tb00977.x
   O'Toole EA, 1999, BRIT J DERMATOL, V140, P283
   Patel GK, 2000, BRIT J DERMATOL, V143, P668, DOI 10.1111/j.1365-2133.2000.03744.x
   PETZELBAUER P, 1992, BRIT J DERMATOL, V126, P542
   Radakovic S, 2010, PHOTODERMATOL PHOTO, V26, P327, DOI 10.1111/j.1600-0781.2010.00543.x
   Radstake TRDJ, 2009, ANN RHEUM DIS, V68, P1739, DOI 10.1136/ard.2008.092833
   Santos-Juanes J, 2004, J EUR ACAD DERMATOL, V18, P199, DOI 10.1111/j.1468-3083.2004.00444.x
   Sodemann K, 1976, Z Gesamte Inn Med, V31, P270
   Vandermeeren M, 1997, BIOCHEM BIOPH RES CO, V234, P19, DOI 10.1006/bbrc.1997.6570
   WHORWELL PJ, 1986, GUT, V27, P1517, DOI 10.1136/gut.27.12.1517
   Yigit S, 2002, J PEDIATR-US, V141, P280, DOI 10.1067/mpd.2002.126302
   Zhang Kevin S, 2009, Dermatol Online J, V15, P12
NR 43
TC 18
Z9 19
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2015
VL 12
IS 5
BP 548
EP 554
DI 10.1111/iwj.12159
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CU8RL
UT WOS:000363810700010
PM 24119190
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Carroll, S
   Borkoles, E
   Polman, R
AF Carroll, Sean
   Borkoles, Erika
   Polman, Remco
TI Short-term effects of a non-dieting lifestyle intervention program on
   weight management, fitness, metabolic risk, and psychological wellbeing
   in obese premenopausal females with the metabolic syndrome
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE metabolic syndrome; lifestyle intervention; "Health at Every Size";
   psychological well-being; obesity; cardiorespiratory fitness;
   non-dieting approach; self-determination
ID QUALITY-OF-LIFE; 3RD NATIONAL-HEALTH; PHYSICAL-ACTIVITY;
   INSULIN-RESISTANCE; DEPRESSION SYMPTOMS; DIABETES-MELLITUS;
   BLOOD-PRESSURE; EXERCISE; PREVENTION; WOMEN
AB Lifestyle modification has been widely acknowledged as the primary treatment for the metabolic syndrome (MetS). We examined the short-term effects of a non-dieting lifestyle intervention program, within the theoretical psychological framework of self-determination theory (SDT), on metabolic fitness and psychological well-being among premenopausal, clinically obese women. A secondary analysis of a randomized, controlled, 3 month, intensive, community-based lifestyle intervention study was performed on 31 pre-menopausal obese women with the MetS (56.4% of original study sample). These participants had been randomly allocated to a non-dieting lifestyle intervention group (n = 17) or waiting list control (n = 14). Among participants who completed repeat anthropometric and cardiorespiratory fitness measurements after 3 months intervention, the lifestyle intervention group showed a significant improvement in VO2 (mL.kg(-1).min(-1)) compared with control (test for interaction, p = 0.003). No significant difference was found for body mass. Metabolic improvements were evident for diastolic blood pressure and high-density lipoprotein cholesterol in both groups. The lifestyle intervention group also showed significantly improved general psychological well-being compared with the control group (test for interaction, p = 0.0005). All of the psychological well-being subscales showed significant favourable changes in the intervention group as compared with controls. This short-term, non-dieting lifestyle intervention, consistent with the "Health at Every Size" (HAES) obesity treatment paradigm, significantly improved cardiorespiratory fitness and psychological well-being. Metabolic risk tended to improve after 3 months intervention with no significant difference in the resolution of the MetS between intervention and control participants.
C1 Univ Hull, Dept Sport Hlth & Exercise Sci, Kingston Upon Hull HU6 7RX, N Humberside, England.
   Leeds Metropolitan Univ, Carnegie Fac Sport & Educ, Leeds LS1 3HE, W Yorkshire, England.
C3 University of Hull; Leeds Beckett University
RP Carroll, S (corresponding author), Univ Hull, Dept Sport Hlth & Exercise Sci, Cottingham Rd, Kingston Upon Hull HU6 7RX, N Humberside, England.
EM s.carroll@hull.ac.uk
RI Borkoles, Erika/M-8802-2019; Polman, Remco/D-1877-2013; Borkoles,
   Erika/N-1950-2013
OI Polman, Remco/0000-0003-2951-0904; Borkoles, Erika/0000-0002-7807-8890
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Bacon L, 2002, INT J OBESITY, V26, P854, DOI 10.1038/sj.ijo.0802012
   Balkau B, 2003, DIABETES METAB, V29, P526, DOI 10.1016/S1262-3636(07)70067-8
   Balkau B, 2002, DIABETES METAB, V28, P364
   BJORNTORP P, 1991, J INTERN MED, V230, P195
   Björntorp P, 1999, ANN NY ACAD SCI, V892, P297, DOI 10.1111/j.1749-6632.1999.tb07803.x
   Bjorntorp P, 1996, J INTERN MED, V239, P105, DOI 10.1046/j.1365-2796.1996.364690000.x
   Brekke HK, 2005, DIABETES RES CLIN PR, V68, P18, DOI 10.1016/j.diabres.2004.07.023
   Brunner R.L., 1997, Obesity assessment: Tools, methods, interpretations, P471
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Ciliska D, 1998, WESTERN J NURS RES, V20, P119, DOI 10.1177/019394599802000108
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   CRAMER SR, 1991, J PSYCHOSOM RES, V35, P437, DOI 10.1016/0022-3999(91)90039-Q
   Deci E. L., 1985, Intrinsic motivation and self-determination in human behavior, P11
   Delahanty LM, 2006, J AM DIET ASSOC, V106, P698, DOI 10.1016/j.jada.2006.02.011
   Dengel DR, 1998, METABOLISM, V47, P1075, DOI 10.1016/S0026-0495(98)90281-5
   Dunn AL, 1999, JAMA-J AM MED ASSOC, V281, P327, DOI 10.1001/jama.281.4.327
   Dupuy H., 1984, ASSESSMENT QUALITY L, P170
   DUPUY H, 1977, US DHEW PUBLICATION, pR3
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   EDWARDS DW, 1978, EVALUATION QUART, V2, P275, DOI 10.1177/0193841X7800200206
   Einhorn Daniel, 2003, Endocr Pract, V9, P237
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   Fazio A., 1977, Vital and health statistics, series, V2
   Fogelholm M, 2000, ARCH INTERN MED, V160, P2177, DOI 10.1001/archinte.160.14.2177
   Fontaine KR, 1999, QUAL LIFE RES, V8, P275, DOI 10.1023/A:1008835602894
   Foreyt JP, 2005, AM J CARDIOL, V96, p11E, DOI 10.1016/j.amjcard.2005.05.009
   FOREYT JP, 1995, INT J OBESITY, V19, pS69
   Friedman KE, 2002, OBES RES, V10, P33, DOI 10.1038/oby.2002.5
   GRAY DS, 1989, AM J CLIN NUTR, V50, P255, DOI 10.1093/ajcn/50.2.255
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Grundy Scott M, 2006, Nat Rev Drug Discov, V5, P295, DOI 10.1038/nrd2005
   Grundy SM, 2006, J AM COLL CARDIOL, V47, P1093, DOI 10.1016/j.jacc.2005.11.046
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   HELLENIUS ML, 1995, QUAL LIFE RES, V4, P13, DOI 10.1007/BF00434378
   HEWITT PL, 1992, J PSYCHOPATHOL BEHAV, V14, P247, DOI 10.1007/BF00962631
   Hildebrandt E, 2005, PUBLIC HEALTH NURS, V22, P506, DOI 10.1111/j.0737-1209.2005.220606.x
   Hillier TA, 2006, DIABETOLOGIA, V49, P1528, DOI 10.1007/s00125-006-0266-8
   Hollis S, 1999, BRIT MED J, V319, P670, DOI 10.1136/bmj.319.7211.670
   Horsten M, 1999, J CARDIOVASC RISK, V6, P391
   Janssen I, 2002, DIABETES CARE, V25, P431, DOI 10.2337/diacare.25.3.431
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   Katzmarzyk PT, 2006, DIABETES CARE, V29, P404, DOI 10.2337/diacare.29.02.06.dc05-1636
   Katzmarzyk PT, 2005, DIABETES CARE, V28, P391, DOI 10.2337/diacare.28.2.391
   Katzmarzyk PT, 2003, MED SCI SPORT EXER, V35, P1703, DOI 10.1249/01.MSS.0000089337.73244.9B
   Kiernan M, 2001, OBES RES, V9, P770, DOI 10.1038/oby.2001.106
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Klem ML, 1997, INT J EAT DISORDER, V21, P167, DOI 10.1002/(SICI)1098-108X(199703)21:2<167::AID-EAT7>3.0.CO;2-J
   KRAUS WE, 2002, NEW ENGL J MED, V347, P1483, DOI DOI 10.1056/NEJMOA020194
   Laaksonen DE, 2005, DIABETES, V54, P158, DOI 10.2337/diabetes.54.1.158
   Lapidus L, 1994, Obes Res, V2, P372
   Lehmann G, 1997, CHEST, V112, P98, DOI 10.1378/chest.112.1.98
   Lindström J, 2006, DIABETOLOGIA, V49, P912, DOI 10.1007/s00125-006-0198-3
   Liu SM, 2001, CURR OPIN LIPIDOL, V12, P395, DOI 10.1097/00041433-200108000-00005
   McAuley KA, 2002, DIABETES CARE, V25, P445, DOI 10.2337/diacare.25.3.445
   MCDOWELL I, 1987, MEASURING HLTH GUIDE, P125
   Mellin L, 1997, J AM DIET ASSOC, V97, P1133, DOI 10.1016/S0002-8223(97)00274-5
   Miller G. D., 1997, OBESITY ASSESSMENT T, P465
   Miller W C, 2001, Obes Rev, V2, P37, DOI 10.1046/j.1467-789x.2001.00023.x
   Miller WC, 1999, MED SCI SPORT EXER, V31, P1129, DOI 10.1097/00005768-199908000-00008
   Nieman DC, 2000, J PSYCHOSOM RES, V48, P23, DOI 10.1016/S0022-3999(99)00066-5
   Orchard TJ, 2005, ANN INTERN MED, V142, P611, DOI 10.7326/0003-4819-142-8-200504190-00009
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   Rippe JM, 1998, OBES RES, V6, P208, DOI 10.1002/j.1550-8528.1998.tb00339.x
   Ross R, 2004, OBES RES, V12, P789, DOI 10.1038/oby.2004.95
   Rubin RR, 2005, DIABETES CARE, V28, P830
   Ryan RM, 2000, AM PSYCHOL, V55, P68, DOI 10.1037/0003-066X.55.1.68
   Sheldon K.M., 2003, Motivating health: Applying selfdetermination theory in the clinic, DOI [DOI 10.12987/YALE/9780300095449.001.0001, DOI 10.12987/YALE/9780300095449.003.0007]
   SILBERSTEIN LR, 1988, SEX ROLES, V19, P219, DOI 10.1007/BF00290156
   Simons-Morton DG, 2006, JAMA-J AM MED ASSOC, V295, P826, DOI 10.1001/jama.295.7.826
   Sorensen M, 1999, J SPORT SCI, V17, P369, DOI 10.1080/026404199365885
   Stewart KJ, 2005, AM J PREV MED, V28, P9, DOI 10.1016/j.amepre.2004.09.006
   Stewart-Knox BJ, 2005, P NUTR SOC, V64, P363, DOI 10.1079/PNS2005444
   Stone NJ, 2005, AM J CARDIOL, V96, p15E, DOI 10.1016/j.amjcard.2005.05.010
   Sullivan VK, 2006, J AM DIET ASSOC, V106, P668, DOI 10.1016/j.jada.2006.03.027
   Thompson J.K., 1995, Handbook of Assessment Methods for Eating Behaviors and Weight-related Problems, P119
   TREMBLAY A A, 1991, Medicine and Science in Sports and Exercise, V23, P1326
   Troxel WM, 2005, ARCH INTERN MED, V165, P1022, DOI 10.1001/archinte.165.9.1022
   Tuomilehto J, 2001, NEW ENGL J MED, V344, P1343, DOI 10.1056/NEJM200105033441801
   Vale S, 2005, POSTGRAD MED J, V81, P429, DOI 10.1136/pgmj.2004.028977
   Wadden TA, 1997, J CONSULT CLIN PSYCH, V65, P269, DOI 10.1037/0022-006X.65.2.269
   Wadden Thomas A, 2002, Obes Res, V10 Suppl 1, p50S, DOI 10.1038/oby.2002.190
   Wamala SP, 1999, DIABETES CARE, V22, P1999, DOI 10.2337/diacare.22.12.1999
   Watkins LL, 2003, ARCH INTERN MED, V163, P1889, DOI 10.1001/archinte.163.16.1889
   Williams GC, 1996, J PERS SOC PSYCHOL, V70, P115, DOI 10.1037/0022-3514.70.1.115
   Williams GC, 1998, DIABETES CARE, V21, P1644, DOI 10.2337/diacare.21.10.1644
   Wilson PWF, 2005, CIRCULATION, V112, P3066, DOI 10.1161/CIRCULATIONAHA.105.539528
   Wing RR, 2004, OBES RES, V12, P1426
NR 92
TC 46
Z9 61
U1 1
U2 35
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD FEB
PY 2007
VL 32
IS 1
BP 125
EP 142
DI 10.1139/H06-093
PG 18
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA 144ZY
UT WOS:000244836300011
PM 17332789
DA 2025-06-11
ER

PT J
AU Gottlieb, AB
   Armstrong, AW
AF Gottlieb, Alice B.
   Armstrong, April W.
TI Psoriasis Outcome Measures: A Report from the GRAPPA 2012 Annual Meeting
SO JOURNAL OF RHEUMATOLOGY
LA English
DT Article
DE PSORIATIC DISEASE; PSORIASIS; OMERACT; NATIONAL PSORIASIS FOUNDATION;
   COMORBIDITIES
ID QUALITY-OF-LIFE; SELF-ADMINISTERED PSORIASIS; SICKNESS IMPACT PROFILE;
   SHORT GENERIC VERSION; SEVERITY INDEX PASI; GLOBAL ASSESSMENT;
   INTRARATER RELIABILITY; EXAMINING INTERRATER; DISEASE SEVERITY; NAIL
   PSORIASIS
AB Psoriasis is a multisystem disease. The cutaneous and musculoskeletal manifestations (psoriatic arthritis) are well recognized. However, the other manifestations of psoriatic disease including metabolic syndrome, atherosclerotic cardiovascular disease, depression, poor self-esteem, and self-destructive habits including obesity, smoking and excess alcohol consumption are underappreciated. At the 2012 annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), members addressed the need to develop uniform, validated, standardized outcome measures for psoriatic disease, measures that are useful to all stakeholders including patients, physicians, regulators, and payers.
C1 [Gottlieb, Alice B.] Tufts Med Ctr, Dept Dermatol, Boston, MA 02111 USA.
   [Armstrong, April W.] Univ Calif Davis, Dept Dermatol, Sacramento, CA 95817 USA.
C3 Tufts Medical Center; University of California System; University of
   California Davis
RP Gottlieb, AB (corresponding author), Tufts Med Ctr, 800 Washington St,Box 114, Boston, MA 02111 USA.
EM agottlieb@tuftsmedicalcenter.org
FU Advancing Innovation in Dermatology Foundation
FX Supported in part by a grant from the Advancing Innovation in
   Dermatology Foundation.
CR Ashcroft DM, 1999, BRIT J DERMATOL, V141, P185
   Augustin M, 2004, DERMATOLOGY, V209, P14, DOI 10.1159/000078581
   Augustin M, 2000, DERMATOL PSYCHOSOM, V1, P12
   Beck AT, 1996, J PERS ASSESS, V67, P588, DOI 10.1207/s15327752jpa6703_13
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   Berth-Jones J, 2008, BRIT J DERMATOL, V159, P407, DOI 10.1111/j.1365-2133.2008.08680.x
   Berth-Jones J, 2006, BRIT J DERMATOL, V155, P707, DOI 10.1111/j.1365-2133.2006.07389.x
   Boers M, 1998, J RHEUMATOL, V25, P198
   BRAZIER JE, 1992, BMJ-BRIT MED J, V305, P160, DOI 10.1136/bmj.305.6846.160
   Bushnell DM, 2012, J DERMATOLOG TREAT
   Cauli A, 2011, J RHEUMATOL, V38, P898, DOI 10.3899/jrheum.100857
   Chren MM, 1996, J INVEST DERMATOL, V107, P707, DOI 10.1111/1523-1747.ep12365600
   Chren MM, 1997, ARCH DERMATOL, V133, P1433, DOI 10.1001/archderm.133.11.1433
   Crown WH, 2004, CURR MED RES OPIN, V20, P1929, DOI 10.1185/030079904X15192
   DEBRUIN AF, 1994, J CLIN EPIDEMIOL, V47, P863, DOI 10.1016/0895-4356(94)90189-9
   DEBRUIN AF, 1994, J CLIN EPIDEMIOL, V47, P407, DOI 10.1016/0895-4356(94)90162-7
   Farhi D, 2008, J INVEST DERMATOL, V128, P2198, DOI 10.1038/jid.2008.68
   Faust HB, 1997, ARCH DERMATOL, V133, P1443, DOI 10.1001/archderm.133.11.1443
   Feldman SR, 2005, BRIT J DERMATOL, V152, P382, DOI 10.1111/j.1365-2133.2005.06351.x
   Feldman SR, 2005, ANN RHEUM DIS, V64, P65, DOI 10.1136/ard.2004.031237
   Feldman SR, 1996, J INVEST DERMATOL, V106, P183, DOI 10.1111/1523-1747.ep12329912
   FINLAY AY, 1990, BRIT J DERMATOL, V123, P751, DOI 10.1111/j.1365-2133.1990.tb04192.x
   FINLAY AY, 1994, CLIN EXP DERMATOL, V19, P210, DOI 10.1111/j.1365-2230.1994.tb01167.x
   Fleischer Alan B. Jr., 1999, Journal of Dermatology (Tokyo), V26, P210
   Fong DYT, 2010, J CLIN EPIDEMIOL, V63, P1020, DOI 10.1016/j.jclinepi.2009.11.011
   FREDRIKSSON T, 1978, DERMATOLOGICA, V157, P238, DOI 10.1159/000250839
   Gordon KB, 2003, JAMA-J AM MED ASSOC, V290, P3073, DOI 10.1001/jama.290.23.3073
   Gottlieb Alice B, 2003, J Drugs Dermatol, V2, P260
   Harari M, 2000, INT J DERMATOL, V39, P913, DOI 10.1046/j.1365-4362.2000.00017.x
   Hawker GA, 2011, ARTHRIT CARE RES, V63, pS240, DOI 10.1002/acr.20543
   Horn EJ, 2007, J AM ACAD DERMATOL, V57, P957, DOI 10.1016/j.jaad.2007.06.042
   Jacobson CC, 2004, BRIT J DERMATOL, V151, P381, DOI 10.1111/j.1365-2133.2004.06035.x
   Jemec GBE, 2011, J EUR ACAD DERMATOL, V25, P27, DOI 10.1111/j.1468-3083.2010.03682.x
   Kimball AB, 2011, J EUR ACAD DERMATOL, V25, P157, DOI 10.1111/j.1468-3083.2010.03730.x
   Kirby B, 2000, BRIT J DERMATOL, V142, P728, DOI 10.1046/j.1365-2133.2000.03418.x
   Koo J., 2003, Dermatologie Psychosomatik, V3, P171, DOI [10.1159/000069253, DOI 10.1159/000069253]
   Langley RG, 2004, J AM ACAD DERMATOL, V51, P563, DOI 10.1016/j.jaad.2004.04.012
   Leonardi CL, 2003, NEW ENGL J MED, V349, P2014, DOI 10.1056/NEJMoa030409
   Lerner D, 2002, J CLIN EPIDEMIOL, V55, P197, DOI 10.1016/S0895-4356(01)00424-3
   Lerner D, 2001, MED CARE, V39, P72, DOI 10.1097/00005650-200101000-00009
   LEWISJONES MS, 1995, BRIT J DERMATOL, V132, P942
   Lipps GE, 2010, W INDIAN MED J, V59, P374
   Louden B Asher, 2004, Dermatol Online J, V10, P7
   Mease PJ, 2011, ARTHRIT CARE RES, V63, pS64, DOI 10.1002/acr.20577
   MOOREY S, 1991, BRIT J PSYCHIAT, V158, P255, DOI 10.1192/bjp.158.2.255
   Morgan M, 1997, BRIT J DERMATOL, V136, P202
   Nichol MB, 1996, PHARMACOECONOMICS, V10, P644, DOI 10.2165/00019053-199610060-00010
   Ortonne JP, 2005, BMC DERMATOL, V5, DOI 10.1186/1471-5945-5-13
   RAMSAY B, 1991, BRIT J DERMATOL, V124, P565, DOI 10.1111/j.1365-2133.1991.tb04952.x
   REILLY MC, 1993, PHARMACOECONOMICS, V4, P353, DOI 10.2165/00019053-199304050-00006
   Revicki D, 2008, BRIT J DERMATOL, V158, P549, DOI 10.1111/j.1365-2133.2007.08236.x
   Revicki DA, 2008, DERMATOLOGY, V216, P260, DOI 10.1159/000113150
   Rich P, 2003, J AM ACAD DERMATOL, V49, P206, DOI 10.1067/S0190-9622(03)00910-1
   Rogers A, 2012, DERMATOL CLIN, V30, P333, DOI 10.1016/j.det.2011.11.010
   Sampogna F, 2003, ARCH DERMATOL, V139, P353, DOI 10.1001/archderm.139.3.353
   Schleyer V, 2006, J EUR ACAD DERMATOL, V20, P823, DOI 10.1111/j.1468-3083.2006.01651.x
   Schmitt J, 2005, DERMATOLOGY, V210, P194, DOI 10.1159/000083509
   Shikiar Richard, 2003, Health Qual Life Outcomes, V1, P53, DOI 10.1186/1477-7525-1-53
   Spuls PI, 2010, J INVEST DERMATOL, V130, P933, DOI 10.1038/jid.2009.391
   Toth DP, 2008, DERMATOL THER, V21, pS6, DOI 10.1111/j.1529-8019.2008.00235.x
   Wan J, 2012, J AM ACAD DERMATOL, V66, P376, DOI 10.1016/j.jaad.2011.03.012
   Ware JE, 1996, MED CARE, V34, P220, DOI 10.1097/00005650-199603000-00003
   Williams HC, 1997, ARCH DERMATOL, V133, P1451, DOI 10.1001/archderm.133.11.1451
   ZIGMOND AS, 1983, ACTA PSYCHIAT SCAND, V67, P361, DOI 10.1111/j.1600-0447.1983.tb09716.x
NR 64
TC 24
Z9 24
U1 0
U2 6
PU J RHEUMATOL PUBL CO
PI TORONTO
PA 365 BLOOR ST E, STE 901, TORONTO, ONTARIO M4W 3L4, CANADA
SN 0315-162X
EI 1499-2752
J9 J RHEUMATOL
JI J. Rheumatol.
PD AUG
PY 2013
VL 40
IS 8
BP 1428
EP 1433
DI 10.3899/jrheum.130456
PG 6
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 202CY
UT WOS:000323192300034
PM 23908539
OA Bronze
DA 2025-06-11
ER

PT J
AU Bambhroliya, Z
   Sandrugu, J
   Lowe, M
   Okunlola, O
   Raza, S
   Osasan, S
   Sethia, S
   Batool, T
   Hamid, P
AF Bambhroliya, Zarna
   Sandrugu, Joel
   Lowe, Michael
   Okunlola, Oluwasemilore
   Raza, Shafaat
   Osasan, Stephen
   Sethia, Sudiksha
   Batool, Tayyaba
   Hamid, Pousette
TI Diabetes, Polycystic Ovarian Syndrome, Obstructive Sleep Apnea, and
   Obesity: A Systematic Review and Important Emerging Themes
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE visceral adiposity; metabolic syndrome; diabetes type 2; metabolic
   dysfunction; obesity; hyperandrogenism; polycystic ovary syndrome;
   obstructive sleep apnea; insulin resistance
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; DIAGNOSTIC-CRITERIA; NECK
   CIRCUMFERENCE; BLOOD-PRESSURE; WOMEN; MANAGEMENT; INSULIN; METAANALYSIS;
   ALDOSTERONE
AB Type 2 diabetes mellitus (DM), polycystic ovarian syndrome (PCOS), obstructive sleep apnea (OSA), and obesity represent four large and growing patient populations. A great deal of scientific and clinical knowledge has been developed for them individually, and significant advancements made. Taken as a group, however, the interrelationships are not as well understood. The purpose of this systematic review is to identify the body of existing research that ties them together and then to identify and discuss the prevailing themes, particularly for cause-and-effect mechanisms. PubMed, Google Scholar, and ScienceDirect were used to identify systematic reviews and meta-analysis articles to establish the broadest reach. Initially, 434 articles were carefully screened, out of which 22 most relevant studies were reviewed. Five important themes were distilled from these papers based on continued and consistent emphasis in the literature. These themes include topics such as the importance of considering visceral obesity rather than Body Mass Index (BMI), the most effective treatment approaches, including mounting support for melatonin and circadian rhythm management, the results of OSA in its feed-forward contribution to hormone imbalance, the role of non-obesity-related risk factors to PCOS and OSA such as age and genetic predisposition, and growing evidence to suggest the importance of mental health as a comorbidity in addition to the more traditional ones such as cardiovascular pathology. A new framework for investigating the interaction across these four disorders is offered that includes a revised perspective on the specific role of PCOS, perhaps being further upstream relative to the others. There currently exists a lack of well-designed randomized controlled trials in this particular area of medicine, an endeavor we believe could result in significant value, particularly as it relates to treatment approaches.
C1 [Bambhroliya, Zarna; Sandrugu, Joel; Lowe, Michael; Okunlola, Oluwasemilore; Raza, Shafaat; Osasan, Stephen; Sethia, Sudiksha; Batool, Tayyaba] Calif Inst Behav Neurosci & Psychol, Res, Fairfield, CT USA.
   [Hamid, Pousette] Calif Inst Behav Neurosci & Psychol, Neurol, Fairfield, CT USA.
RP Bambhroliya, Z (corresponding author), Calif Inst Behav Neurosci & Psychol, Res, Fairfield, CT USA.
EM zarna5060@gmail.com
RI Raza, Shafaat/ABQ-4353-2022
OI raza, Dr.shafaat/0000-0002-3186-4587; Okunlola,
   Oluwasemilore/0000-0003-2031-5766
CR Allahdadi KJ, 2008, AM J PHYSIOL-HEART C, V295, pH434, DOI 10.1152/ajpheart.91477.2007
   Amato P, 2004, BEST PRACT RES CL OB, V18, P707, DOI 10.1016/j.bpobgyn.2004.05.002
   American Academy of Dental Sleep Medicine, 2022, SNOR SLEEP APN
   Avgustin N, 2017, CLIN NEPHROL, V88, pS10, DOI 10.5414/CNP88FX03
   Baethge C, 2019, RES INTEGR PEER REV, V4, DOI 10.1186/s41073-019-0064-8
   Bahman M, 2018, INT J PREVENTIVE MED, V9, DOI 10.4103/ijpvm.IJPVM_352_16
   Barber TM, 2006, CLIN ENDOCRINOL, V65, P137, DOI 10.1111/j.1365-2265.2006.02587.x
   Barber TM, 2019, CLIN MED INSIGHTS-RE, V13, DOI 10.1177/1179558119874042
   Barnard L, 2007, HUM REPROD, V22, P2279, DOI 10.1093/humrep/dem108
   Benjafield AV, 2019, LANCET RESP MED, V7, P687, DOI 10.1016/S2213-2600(19)30198-5
   Borel AL, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112628
   Cadagan D, 2016, REPROD BIOL, V16, P53, DOI 10.1016/j.repbio.2015.12.006
   Carneiro G, 2008, AM J PHYSIOL-ENDOC M, V295, pE380, DOI 10.1152/ajpendo.00780.2007
   Carneiro G, 2018, METABOLISM, V84, P76, DOI 10.1016/j.metabol.2018.03.008
   Çelik Ö, 2021, J TURK-GER GYNECOL A, V22, P326, DOI 10.4274/jtgga.galenos.2021.2021.0077
   Ciftci TU, 2005, RESPIRATION, V72, P395, DOI 10.1159/000086254
   Cizza G, 2014, METAB SYNDR RELAT D, V12, P231, DOI 10.1089/met.2013.0093
   Deswal Ritu, 2020, J Hum Reprod Sci, V13, P261, DOI 10.4103/jhrs.JHRS_95_18
   Dokras A, 2016, J CLIN ENDOCR METAB, V101, P2966, DOI 10.1210/jc.2016-1896
   Drager LF, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012065
   El Hayek S, 2016, FRONT PHYSIOL, V7, DOI 10.3389/fphys.2016.00124
   Escobar-Morreale HF, 2017, HUM REPROD UPDATE, V23, P390, DOI 10.1093/humupd/dmx012
   Fauser BCJM, 2004, HUM REPROD, V19, P41, DOI 10.1093/humrep/deh098
   Finn L, 1998, SLEEP, V21, P701
   Fogel RB, 2001, J CLIN ENDOCR METAB, V86, P1175, DOI 10.1210/jc.86.3.1175
   Gottlieb DJ, 2020, JAMA-J AM MED ASSOC, V323, P1389, DOI 10.1001/jama.2020.3514
   Helvaci N, 2022, CLIN ENDOCRINOL, V97, P371, DOI 10.1111/cen.14558
   Helvaci N, 2017, ENDOCR CONNECT, V6, P437, DOI 10.1530/EC-17-0129
   Ip M, 2007, SLEEP MED CLIN, V2, P19, DOI 10.1016/j.jsmc.2006.12.002
   Izumi S, 2016, J CLIN SLEEP MED, V12, P487, DOI 10.5664/jcsm.5672
   Jelodar G, 2013, J BABOL U MED SCI, V13, P96
   Jin ZN, 2016, J GERIATR CARDIOL, V13, P333, DOI 10.11909/j.issn.1671-5411.2016.03.020
   Jonas DE, 2017, AGEN HLTH RES QUAL, V2017
   Kahal H, 2020, SLEEP BREATH, V24, P339, DOI 10.1007/s11325-019-01835-1
   Kahal H, 2018, SLEEP, V41, DOI 10.1093/sleep/zsy085
   Khan MJ, 2019, APPL CLIN GENET, V12, P249, DOI 10.2147/TACG.S200341
   Koren D, 2016, DIABETES METAB SYNDR, V9, P281, DOI 10.2147/DMSO.S95120
   Li C, 2011, MOL HUM REPROD, V17, P193, DOI 10.1093/molehr/gaq087
   Li H, 2013, ENDOCRINE, V43, P184, DOI 10.1007/s12020-012-9739-3
   Li YJ, 2019, SURG OBES RELAT DIS, V15, P942, DOI 10.1016/j.soard.2019.03.032
   Lin TY, 2017, SLEEP MED, V36, P165, DOI 10.1016/j.sleep.2016.12.029
   Livadas S, 2022, WORLD J DIABETES, V13, P5, DOI 10.4239/wjd.v13.i1.5
   Martinez-Rivera C, 2008, OBESITY, V16, P113, DOI 10.1038/oby.2007.20
   Martins FO, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.792633
   Möhlig M, 2006, EUR J ENDOCRINOL, V155, P127, DOI 10.1530/eje.1.02195
   Neven ACH, 2018, SEMIN REPROD MED, V36, P5, DOI 10.1055/s-0038-1668085
   Onat A, 2009, CLIN NUTR, V28, P46, DOI 10.1016/j.clnu.2008.10.006
   Ortiz-Flores AE, 2019, MED CLIN-BARCELONA, V152, P450, DOI 10.1016/j.medcli.2018.11.019
   Piri-Gharaghie Tohid, 2021, PERSO MED JR, V6, P23
   Pratt-Ubunama MN, 2007, CHEST, V131, P453, DOI 10.1378/chest.06-1442
   Saeedi P, 2019, DIABETES RES CLIN PR, V157, DOI 10.1016/j.diabres.2019.107843
   Sam Susan, 2021, Curr Opin Endocr Metab Res, V17, P46, DOI 10.1016/j.coemr.2021.01.002
   Sam S, 2019, CLIN MED INSIGHTS-RE, V13, DOI 10.1177/1179558119871269
   Schmiedt RA, 2021, Acta Marisiensis-Seria Medica, V67, P187, DOI 10.2478/amma-2021-0033
   Shah R, 2019, CHILDREN-BASEL, V6, DOI 10.3390/children6080089
   Shreeve N, 2013, HUM REPROD, V28, P1348, DOI 10.1093/humrep/det013
   Spinedi E, 2018, INT J ENDOCRINOL, V2018, DOI 10.1155/2018/1349868
   Stefanaki C, 2015, STRESS, V18, P57, DOI 10.3109/10253890.2014.974030
   Suri J, 2016, SLEEP MED, V23, P32, DOI 10.1016/j.sleep.2016.02.014
   Tasali E, 2008, SLEEP MED CLIN, V3, P37, DOI 10.1016/j.jsmc.2007.11.001
   Vgontzas AN, 2003, J INTERN MED, V254, P32, DOI 10.1046/j.1365-2796.2003.01177.x
   Witchel SF, 2020, PEDIATR RES, V87, P353, DOI 10.1038/s41390-019-0615-1
   World Health Organization, 2022, OB OV
   Young T, 2005, J APPL PHYSIOL, V99, P1592, DOI 10.1152/japplphysiol.00587.2005
   Zeng X, 2020, CLIN CHIM ACTA, V502, P214, DOI 10.1016/j.cca.2019.11.003
   Zoccal DB, 2007, EXP PHYSIOL, V92, P79, DOI 10.1113/expphysiol.2006.035501
NR 66
TC 12
Z9 13
U1 0
U2 3
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD JUN 25
PY 2022
VL 14
IS 6
AR e26325
DI 10.7759/cureus.26325
PG 11
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA 3N7JM
UT WOS:000836321900021
PM 35911341
DA 2025-06-11
ER

PT J
AU Heo, IR
   Kim, TH
   Jeong, JH
   Heo, M
   Ju, SM
   Yoo, JW
   Lee, SJ
   Cho, YJ
   Jeong, YY
   Lee, JD
   Kim, HC
AF Heo, I. Re
   Kim, Tae Hoon
   Jeong, Jong Hwan
   Heo, Manbong
   Ju, Sun Mi
   Yoo, Jung-Wan
   Lee, Seung Jun
   Cho, Yu Ji
   Jeong, Yi Yeong
   Lee, Jong Deog
   Kim, Ho Cheol
TI Impact of Alcohol Consumption on Quality of Life, Depressive Mood and
   Metabolic Syndrome in Obstructive Lung Disease Patients: Analysis of
   Data from Korean National Health and Nutrition Examination Survey from
   2014 and 2016
SO TUBERCULOSIS AND RESPIRATORY DISEASES
LA English
DT Article
DE Alcohol; Quality of Life; Obstructive Lung Disease; Depression
ID PULMONARY-DISEASE; COPD; EXACERBATIONS; PREVALENCE; HOSPITALIZATIONS;
   MANAGEMENT; DIAGNOSIS
AB Background: The objective of this study was to investigate whether alcohol consump- tion might affect the quality of life (QOL), depressive mood, and metabolic syndrome in patients with obstructive lung disease (OLD).Methods: Data were obtained from the Korean National Health and Nutrition Examina-tion Survey from 2014 and 2016. OLD was defined as spirometry of forced expiratory volume in 1 second/forced vital capacity <0.7 in those aged more than 40 years. QOL was evaluated using the European Quality of Life Questionnaire-5D (EQ-5D) index. Patient Health Questionnaire-9 (PHQ-9) was used to assess the severity of depressive mood. Alcohol consumption was based on a history of alcohol ingestion during the pre-vious month.Results: A total of 984 participants with OLD (695 males, 289 females, age 65.8 +/- 9.7 years) were enrolled. The EQ-5D index was significantly higher in alcohol drinkers (n=525) than in non-alcohol drinkers (n=459) (0.94 +/- 0.11 vs. 0.91 +/- 0.13, p=0.002). PHQ-9 scores were considerably lower in alcohol drinkers than in non-alcohol drinkers (2.15 +/- 3. 57 vs. 2.78 +/- 4.13, p=0.013). However, multiple logistic regression analysis showed that alcohol consumption was not associated with EQ-5D index or PHQ-9 score. Body mass index >= 25 kg/m2, triglyceride >= 150 mg/dL, high-density lipoprotein <40 mg/dL in men and <50 mg/dL in women, and blood pressure >= 130/85 mm Hg were significantly more common in alcohol drinkers than in non-alcohol drinkers (all p<0.05).Conclusion: Alcohol consumption did not change the QOL or depressive mood of OLD patients. However, metabolic syndrome-related factors were more common in alcohol drinkers than in non-alcohol drinkers.
C1 [Heo, I. Re; Kim, Tae Hoon; Kim, Ho Cheol] Gyeongsang Natl Univ, Coll Med, Dept Internal Med, Changwon Hosp, Chang Won, South Korea.
   [Jeong, Jong Hwan; Heo, Manbong; Ju, Sun Mi; Yoo, Jung-Wan; Lee, Seung Jun; Cho, Yu Ji; Jeong, Yi Yeong; Lee, Jong Deog] Gyeongsang Natl Univ, Gyeongsang Natl Univ Hosp, Dept Internal Med, Coll Med, Jinju, South Korea.
   [Kim, Ho Cheol] Gyeongsang Natl Univ, Coll Med, Dept Internal Med, Changwon Hosp, 11 Samjeongja Ro, Chang Won 51472, South Korea.
C3 Gyeongsang National University; Gyeongsang National University;
   Gyeongsang National University Hospital; Gyeongsang National University
RP Kim, HC (corresponding author), Gyeongsang Natl Univ, Coll Med, Dept Internal Med, Changwon Hosp, 11 Samjeongja Ro, Chang Won 51472, South Korea.
EM hochkim@gnu.ac.kr
RI Kim, Cheol-Hee/F-6278-2013
OI Heo, I Re/0000-0002-5832-5233
CR Agustí AGN, 2003, EUR RESPIR J, V21, P347, DOI 10.1183/09031936.03.00405703
   [Anonymous], 2007, EQ-5D Korean valuation study using time trade off method
   Appleton A, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15071333
   Baik I, 2008, AM J CLIN NUTR, V87, P1455, DOI 10.1093/ajcn/87.5.1455
   Breyer MK, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0098013
   Burgel PR, 2013, RESP MED, V107, P233, DOI 10.1016/j.rmed.2012.10.002
   Burgel PR, 2009, CHEST, V135, P975, DOI 10.1378/chest.08-2062
   Donohue JF, 2018, INT J CHRONIC OBSTR, V13, P499, DOI 10.2147/COPD.S141729
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Nguyen HT, 2019, INT J CHRONIC OBSTR, V14, P215, DOI 10.2147/COPD.S181322
   Koskela J, 2014, BMC PULM MED, V14, DOI 10.1186/1471-2466-14-102
   Kunik ME, 2005, CHEST, V127, P1205, DOI 10.1378/chest.127.4.1205
   Kweon S, 2014, INT J EPIDEMIOL, V43, P69, DOI 10.1093/ije/dyt228
   Lee Hye-Young, 2019, Korean Journal of Family Practice, V9, P297, DOI 10.21215/kjfp.2019.9.3.297
   Levola J, 2018, QUAL LIFE RES, V27, P1217, DOI 10.1007/s11136-017-1741-z
   Lipovec NC, 2016, COPD, V13, P399, DOI 10.3109/15412555.2016.1140732
   Mäkelä P, 2015, EUR J PUBLIC HEALTH, V25, P225, DOI 10.1093/eurpub/cku133
   Mannino DM, 2008, EUR RESPIR J, V32, P962, DOI 10.1183/09031936.00012408
   Miravitlles M, 2004, THORAX, V59, P387, DOI 10.1136/thx.2003.008730
   Niewoehner DE, 2007, CHEST, V131, P20, DOI 10.1378/chest.06-1316
   Park BH, 2012, INT J TUBERC LUNG D, V16, P694, DOI 10.5588/ijtld.11.0180
   Raherison C, 2014, BMC WOMENS HEALTH, V14, DOI 10.1186/1472-6874-14-31
   Ryynänen OP, 2013, BMC MED INFORM DECIS, V13, DOI 10.1186/1472-6947-13-34
   Schols AM, 2014, EUR RESPIR J, V44, P1504, DOI 10.1183/09031936.00070914
   Sook Lee， Eun, 2020, [Journal of the Korea Convergence Society, 한국융합학회논문지], V11, P319, DOI 10.15207/JKCS.2020.11.7.319
   Vogelmeier CF, 2017, AM J RESP CRIT CARE, V195, P557, DOI 10.1164/rccm.201701-0218PP
   Wilson Ian, 2006, Int J Chron Obstruct Pulmon Dis, V1, P61, DOI 10.2147/copd.2006.1.1.61
   Yi Y, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17249513
   Yoon YS, 2004, AM J CLIN NUTR, V80, P217
NR 29
TC 4
Z9 4
U1 0
U2 2
PU TAEHAN KYORHAEK HYOPHOE-KOREAN ACAD TUBERCULOSIS & RESPIRATORY DISEASES
PI SEOUL
PA 101-605 SEOCHO ART XI 1583-10 SEOCHO 3-DONG, SEOCHO-GU, SEOUL, 137-875,
   SOUTH KOREA
SN 1738-3536
EI 2005-6184
J9 TUBERC RESPIR DIS
JI Tuberc. Respir. Dis.
PD APR
PY 2023
VL 86
IS 2
BP 111
EP 119
DI 10.4046/trd.2022.0107
PG 9
WC Respiratory System
WE Emerging Sources Citation Index (ESCI)
SC Respiratory System
GA D6BR1
UT WOS:000969569600005
PM 37005091
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ek, C
   Hebert, JR
   Friedman, DB
   Porter, DE
AF Ek, Christina
   Hebert, James R.
   Friedman, Daniela B.
   Porter, Dwayne E.
TI Climate Change, Racism, and Food Insecurity: Cyclical Impacts of
   Stressors Exacerbate Health Disparities
SO JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
LA English
DT Review; Early Access
DE Climate change; Racism; Dietary Inflammatory Index; Allostatic load;
   Chronic disease; Health disparities
ID METABOLIC SYNDROME; JOHN HENRYISM; NUTRITION; MALNUTRITION; ETHNICITY;
   DYNAMICS; COVID-19; OBESITY; RISK
AB IntroductionDisadvantaged populations have higher rates of chronic disease, including heart disease, cancer, and diabetes. Race, ethnicity, lower socioeconomic status, and poverty all contribute to these disproportionate rates. Other factors, including systemic racism, climate change, poor diet, lack of food access, and epigenetic influences, that are distributed and experienced differently across vulnerable populations also play a significant role in the development of chronic diseases. This comprehensive review of contributors to chronic diseases emphasizes a unique focus on these identified emerging factors.MethodsAn ad hoc literature review using OVID Medline and Web of Science was conducted.ResultsFindings from prior studies indicate that multiple stressors, both in isolation and in combination, and their negative impacts on both physical and mental health of minorities are exacerbated by climate change.DiscussionVarious stressors dramatically increase chronic disease risk in minority groups. Recommendations for future research to elucidate the impacts of climatic, racial, and dietary adversity with minority populations are presented. Further study in this area is critical for achieving the UN Sustainable Development Goals and improving public health outcomes.
C1 [Ek, Christina; Porter, Dwayne E.] Univ South Carolina, Arnold Sch Publ Hlth, Dept Environm Hlth Sci, Columbia, SC 29208 USA.
   [Hebert, James R.] Univ South Carolina, Dept Epidemiol & Biostat, Columbia, SC USA.
   [Hebert, James R.] Univ South Carolina, Canc Prevent & Control Program, Columbia, SC USA.
   [Friedman, Daniela B.] Univ South Carolina, Arnold Sch Publ Hlth, Dept Hlth Promot Educ & Behav, Columbia, SC USA.
C3 University of South Carolina System; University of South Carolina
   Columbia; University of South Carolina System; University of South
   Carolina Columbia; University of South Carolina System; University of
   South Carolina Columbia; University of South Carolina System; University
   of South Carolina Columbia
RP Ek, C (corresponding author), Univ South Carolina, Arnold Sch Publ Hlth, Dept Environm Hlth Sci, Columbia, SC 29208 USA.
EM ekl@email.sc.edu
RI Hebert, James/IUO-5628-2023; Friedman, Daniela/IAR-1058-2023
FU Carolinas Consortium
FX Open access funding provided by the Carolinas Consortium.
CR Ahdoot S, 2024, PEDIATRICS, V153, DOI 10.1542/peds.2023-065504
   Ahmed A, 2023, DIABETIC MED, V40, DOI 10.1111/dme.15213
   Akerlof KL, 2015, INT J ENV RES PUB HE, V12, P15419, DOI 10.3390/ijerph121214994
   Ammous F, 2022, CLIN EPIGENETICS, V14, DOI 10.1186/s13148-022-01229-3
   Anastasiou K, 2023, GLOB FOOD SECUR-AGR, V37, DOI 10.1016/j.gfs.2023.100688
   Barcelona V, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23168951
   Bekkar B, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.8243
   Berberian AG, 2022, CURR ENV HLTH REP, V9, P451, DOI 10.1007/s40572-022-00360-w
   Black R, 2003, B WORLD HEALTH ORGAN, V81, P79
   Boulund U, 2022, CELL HOST MICROBE, V30, P1464, DOI 10.1016/j.chom.2022.08.013
   Brown NI, 2023, NUTRIENTS, V15, DOI 10.3390/nu15184065
   Burns J, 2021, PEDIATRICS, V148, DOI 10.1542/peds.2020-041350
   Cave L, 2020, BMC PUBLIC HEALTH, V20, DOI 10.1186/s12889-020-09978-7
   Chakraborty T, 2019, ENVIRON RES LETT, V14, DOI 10.1088/1748-9326/ab3b99
   Chitrala KN, 2020, EPIGENETICS-US, V15, P462, DOI 10.1080/15592294.2019.1695340
   Choi DD, 2019, P NATL ACAD SCI USA, V116, P16274, DOI 10.1073/pnas.1820146116
   Clearfield M, 2018, J AM OSTEOPATH ASSOC, V118, P719, DOI 10.7556/jaoa.2018.157
   Clearfield M, 2014, CURR ATHEROSCLER REP, V16, DOI 10.1007/s11883-013-0380-2
   Creighton CJ, 2023, EPIGENETICS-US, V18, DOI 10.1080/15592294.2023.2180585
   Crooks DL, 1995, YEARB PHYS ANTHROPOL, V38, P57
   Cummings JH, 2018, NUTR RES REV, V31, P1, DOI 10.1017/S0954422417000117
   Dawson D, 2023, J RACIAL ETHN HEALTH, V10, P2641, DOI 10.1007/s40615-022-01442-z
   De la Cadena M., 1998, Bulletin of Latin American Studies, V17, P143, DOI [DOI 10.1111/J.1470-9856.1998.TB00169.X, 10.1016/S0261-3050(97)00085-5]
   Denis GV, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0196755
   Domínguez-Cruz MG, 2020, GENE, V730, DOI 10.1016/j.gene.2019.144259
   Drolet CE, 2020, J BEHAV MED, V43, P932, DOI 10.1007/s10865-020-00146-1
   Ducharme-Smith K, 2021, J NUTR, V151, P1609, DOI 10.1093/jn/nxab027
   Elenwo C, 2024, J OSTEOPATH MED, V124, P407, DOI 10.1515/jom-2024-0016
   Fanzo J, 2018, GLOB FOOD SECUR-AGR, V18, P12, DOI 10.1016/j.gfs.2018.06.001
   Finch CE, 2012, P AM PHILOS SOC, V156, P9
   Francisco V, 2019, BIOCHEM PHARMACOL, V165, P196, DOI 10.1016/j.bcp.2019.03.030
   Gilbert E, 2011, INT J HERIT STUD, V17, P62, DOI 10.1080/13527258.2011.524007
   Gillespie SL, 2022, BRAIN BEHAV IMMUN, V101, P266, DOI 10.1016/j.bbi.2022.01.008
   Gutschow B, 2021, CURR PROB PEDIATR AD, V51, DOI 10.1016/j.cppeds.2021.101028
   Ha TY, 1998, Korean J Immunol, P349
   Hansen A, 2013, GLOBAL HEALTH ACTION, V6, P1, DOI 10.3402/gha.v6i0.21364
   Hartmann Phillipp, 2018, Clin Liver Dis (Hoboken), V11, P11, DOI 10.1002/cld.685
   Jackson JS, 2010, AM J PUBLIC HEALTH, V100, P933, DOI 10.2105/AJPH.2008.143446
   JAMES SA, 1994, CULT MED PSYCHIAT, V18, P163, DOI 10.1007/BF01379448
   Johnson AJ, 2022, STRESS HEALTH, V38, P1001, DOI 10.1002/smi.3152
   Jyoti DF, 2005, J NUTR, V135, P2831, DOI 10.1093/jn/135.12.2831
   Kebede AS, 2021, SCI TOTAL ENVIRON, V768, DOI 10.1016/j.scitotenv.2020.144461
   Keusch GT, 2003, J NUTR, V133, p336S, DOI 10.1093/jn/133.1.336S
   Kramer EM, 1997, EUR J CLIN NUTR, V51, P750, DOI 10.1038/sj.ejcn.1600477
   Lanza KV, 2023, URBAN CLIM, V51, DOI 10.1016/j.uclim.2023.101656
   Lebenthal E, 2007, J NUTR, V137, P1073, DOI 10.1093/jn/137.4.1073
   Macias-Verde D, 2021, MED HYPOTHESES, V146, DOI 10.1016/j.mehy.2020.110396
   Manning C., 2018, Psychology and Climate Change, P217, DOI [10.1016/b978-0-12-813130-5.00009-6, DOI 10.1016/B978-0-12-813130-5.00009-6, 10.1016/B978-0-12-813130-5.00009-6]
   Marmot MG, 2006, JAMA-J AM MED ASSOC, V295, P1304, DOI 10.1001/jama.295.11.1304
   Matthews KA, 2019, PSYCHOSOM MED, V81, P176, DOI 10.1097/PSY.0000000000000652
   Mauvais-Jarvis F, 2020, DIABETES, V69, P1857, DOI 10.2337/dbi19-0023
   Misra A, 2008, J CLIN ENDOCR METAB, V93, pS9, DOI 10.1210/jc.2008-1595
   Owen DL, 2019, J IMMUNOL, V203, P2031, DOI 10.4049/jimmunol.1900662
   Peek MK, 2010, AM J PUBLIC HEALTH, V100, P940, DOI 10.2105/AJPH.2007.129312
   Plotkin SA, 1996, PEDIATR INFECT DIS J, V15, P391, DOI 10.1097/00006454-199605000-00002
   Popkin BM, 2006, AM J CLIN NUTR, V84, P289, DOI 10.1093/ajcn/84.2.289
   Popkin BM, 2022, OBES REV, V23, DOI 10.1111/obr.13366
   Popkin BM, 2020, LANCET, V395, P65, DOI 10.1016/S0140-6736(19)32497-3
   Priest N, 2020, BRAIN BEHAV IMMUN, V87, P660, DOI 10.1016/j.bbi.2020.02.012
   Raja US, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-24517-7
   Roberts NLS, 2024, JAMA CARDIOL, V9, P692, DOI 10.1001/jamacardio.2024.1286
   Rong YD, 2018, BMC GERIATR, V18, DOI 10.1186/s12877-018-1007-9
   Rosenkrantz BarbaraG., 1972, Public Health and the State: Changing Views in Massachusetts, 1842-1936
   Roy AS, 2023, SOC SCI MED, V322, DOI 10.1016/j.socscimed.2023.115804
   Ryznar RJ, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph182312728
   Saelee R, 2024, J NUTR, V154, P785, DOI 10.1016/j.tjnut.2023.12.041
   Schenk EC, 2021, AM J NURS, V121, P66, DOI 10.1097/01.NAJ.0000758540.26343.2e
   Scrimshaw NS, 2010, FOOD NUTR BULL, V31, P54, DOI 10.1177/156482651003100107
   Selvamani Y, 2022, AGING MENT HEALTH, V26, P2339, DOI 10.1080/13607863.2021.1985965
   Shafiee M, 2022, ADV NUTR, V13, P2537, DOI 10.1093/advances/nmac081
   Shaker Y, 2023, AGR HUM VALUES, V40, P101, DOI 10.1007/s10460-022-10340-3
   Shonkoff JP, 2021, ANNU REV PUBL HEALTH, V42, P115, DOI 10.1146/annurev-publhealth-090419-101940
   Sistrunk C, 2022, FRONT CARDIOVASC MED, V9, DOI 10.3389/fcvm.2022.756734
   Song JW, 2020, CELL METAB, V32, P188, DOI 10.1016/j.cmet.2020.06.016
   Strzelak A, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15051033
   Tessler H, 2020, AM J CRIM JUSTICE, V45, P636, DOI 10.1007/s12103-020-09541-5
   United Nation, 17 goals to transform our world
   Vind AC, 2023, ANTIOXID REDOX SIGN, V39, P336, DOI 10.1089/ars.2022.0157
   Volek JS, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1141859
   Welch RM, 2002, PLANT SOIL, V247, P83, DOI 10.1023/A:1021140122921
   White A, 2021, NEW ENGL J MED, V385, P850, DOI 10.1056/NEJMms2035550
   Zilioli S, 2022, J GERONTOL A-BIOL, V77, pE56, DOI 10.1093/gerona/glab280
NR 82
TC 0
Z9 0
U1 3
U2 4
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 2197-3792
EI 2196-8837
J9 J RACIAL ETHN HEALTH
JI J. Racial Ethn. Health Disparities
PD 2024 OCT 16
PY 2024
DI 10.1007/s40615-024-02202-x
EA OCT 2024
PG 12
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA I9M0X
UT WOS:001333410100001
PM 39412743
OA hybrid
DA 2025-06-11
ER

PT J
AU Wärdig, R
   Bachrach-Lindström, M
   Hultsjö, S
   Lindström, T
   Foldemo, A
AF Wardig, Rikard
   Bachrach-Lindstrom, Margareta
   Hultsjo, Sally
   Lindstrom, Torbjorn
   Foldemo, Anniqa
TI Persons with psychosis perceptions of participating in a lifestyle
   intervention
SO JOURNAL OF CLINICAL NURSING
LA English
DT Article
DE lifestyle intervention; metabolic syndrome; nursing; perceptions;
   psychosis; qualitative method
ID MENTAL-HEALTH-SERVICES; SELF-CARE; PHYSICAL-ACTIVITY; SCHIZOPHRENIA;
   INDIVIDUALS; ILLNESS; PHENOMENOGRAPHY
AB Aims and objectivesTo describe how persons with psychosis perceive participation in a lifestyle intervention, and use these perceptions to present factors to for consideration in future interventions.
   BackgroundMetabolic syndrome is common in persons with psychosis. A healthy lifestyle is the primary option for preventing and treating metabolic syndrome, which is why the importance of lifestyle interventions has come into focus among health care professionals. Identifying perceptions of participation in a lifestyle intervention can increase the understanding of how to design future interventions.
   DesignA qualitative, phenomenographic approach was selected, using semi-structured interviews.
   MethodsThe sample consisted of 40 participants with a psychotic disorder, who had undergone a lifestyle intervention focusing on theoretical education in healthy eating and physical activities. The interviews were conducted in 2011 and 2012, six to seven months after the intervention had been completed.
   ResultsThe findings comprise three categories that emphasise the need for a moderate intervention level that facilitates participation and thereby social interactions among group members. The experience of success in the intervention supported the perception of oneself as a capable individual. However, it could also be the opposite, another experience of failure.
   ConclusionContent in moderation can facilitate participation, and participants can thereby achieve health benefits and find social contacts. In addition to physical activity and lifestyle habits, interventions should have a social focus and be continuous. Professional support is a prerequisite and should facilitate the participants' ability to mirror themselves against healthy people in society by introducing activities that ordinary people do.
   Relevance for clinical practiceIdentifying perceptions of participation in a lifestyle intervention can increase the understanding of how to design and manage future interventions. This is also an aspect that is important to consider in everyday clinical practice.
C1 [Wardig, Rikard; Bachrach-Lindstrom, Margareta; Lindstrom, Torbjorn; Foldemo, Anniqa] Linkoping Univ, Dept Med & Hlth Sci, S-58183 Linkoping, Sweden.
   [Hultsjo, Sally] Ryhov Cty Hosp, Psychiat Clin, Jonkoping, Sweden.
C3 Linkoping University
RP Wärdig, R (corresponding author), Linkoping Univ, Dept Med & Hlth Sci, S-58183 Linkoping, Sweden.
EM rikard.wardig@liu.se
FU County Council of Ostergotland; Linkoping University; Psychiatric
   Clinic, county Hospital, Ryhov, Jonkoping, Sweden
FX This study was financially supported by the County Council of
   Ostergotland and Linkoping University and the Psychiatric Clinic, county
   Hospital, Ryhov, Jonkoping, Sweden.
CR [Anonymous], INT CLASS DIS ICD 10
   Becker W., 2004, Scandinavian Journal of Nutrition, V48, P178, DOI 10.1080/1102680410003794
   Blythe J, 2012, INT J MENT HEALTH NU, V21, P193, DOI 10.1111/j.1447-0349.2011.00792.x
   Bonfioli E, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-78
   Borras L, 2009, EUR PSYCHIAT, V24, P307, DOI 10.1016/j.eurpsy.2009.01.003
   Bradshaw T, 2010, J PSYCHIATR MENT HLT, V17, P473, DOI 10.1111/j.1365-2850.2009.01543.x
   Brunero S, 2010, INT J NURS STUD, V47, P753, DOI 10.1016/j.ijnurstu.2009.11.004
   Castelein S, 2008, ACTA PSYCHIAT SCAND, V118, P64, DOI 10.1111/j.1600-0447.2008.01216.x
   Dahlgren L., 1991, Journal of Social and Administration Pharmacy, V8, P150, DOI DOI 10.1080/17482620601068105
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P138
   Dolan P, 1997, MED CARE, V35, P1095, DOI 10.1097/00005650-199711000-00002
   El-Mallakh P, 2006, ARCH PSYCHIAT NURS, V20, P55, DOI 10.1016/j.apnu.2005.09.002
   Forsberg KA, 2010, SCANDINAVIAN J CARIN, V25, P357
   Happell B, 2011, J PSYCHIATR MENT HLT, V18, P706, DOI 10.1111/j.1365-2850.2010.01666.x
   Hultsjo Sally, 2013, Open Nurs J, V7, P114, DOI 10.2174/1874434601307010114
   Hultsjö S, 2013, ISSUES MENT HEALTH N, V34, P665, DOI 10.3109/01612840.2013.794178
   International Diabetes Federation, 2006, UN FOR DIAB
   Johnstone R, 2009, J MENT HEALTH, V18, P523, DOI 10.3109/09638230903111114
   Kinter ET, 2009, INT J TECHNOL ASSESS, V25, P35, DOI 10.1017/S0266462309090059
   Lucock M, 2011, HEALTH SOC CARE COMM, V19, P602, DOI 10.1111/j.1365-2524.2011.01014.x
   Lundberg B, 2008, INT J SOC PSYCHIATR, V54, P47, DOI 10.1177/0020764007082345
   MARTON F, 1981, INSTR SCI, V10, P177, DOI 10.1007/BF00132516
   Marton F., 1997, LEARNING AWARENESS
   Patton M. Q., 2002, QUALITATIVE RES EVAL
   Pearsall R, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/1471-244X-14-117
   Pickens JM, 1999, NURS SCI QUART, V12, P233, DOI 10.1177/08943189922107007
   Porsdal V, 2010, BIOMED CENTRAL PSYCH, V10, P1
   Richardson CR, 2005, PSYCHIAT SERV, V56, P324, DOI 10.1176/appi.ps.56.3.324
   Riegel B, 2012, ADV NURS SCI, V35, P194, DOI 10.1097/ANS.0b013e318261b1ba
   Sjöström B, 2002, J ADV NURS, V40, P339, DOI 10.1046/j.1365-2648.2002.02375.x
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Thornicroft G, 2011, BRIT J PSYCHIAT, V199, P441, DOI 10.1192/bjp.bp.111.092718
   Vandyk AD, 2012, INT J MENT HEALTH NU, V21, P349, DOI 10.1111/j.1447-0349.2011.00790.x
   Wärdig RE, 2013, ISSUES MENT HEALTH N, V34, P602, DOI 10.3109/01612840.2013.790525
NR 34
TC 12
Z9 13
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1067
EI 1365-2702
J9 J CLIN NURS
JI J. Clin. Nurs.
PD JUL
PY 2015
VL 24
IS 13-14
BP 1815
EP 1824
DI 10.1111/jocn.12782
PG 10
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA CL3TG
UT WOS:000356872900007
PM 25664402
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Park, H
   Choi, S
   Kim, KH
   Kang, E
   Ko, A
   Park, SM
AF Park, Hyeah
   Choi, Seulggie
   Kim, Kyae Hyung
   Kang, EunKyo
   Ko, Ahryoung
   Park, Sang Min
TI Association between Social Trust and Metabolic Syndrome in a Previously
   Healthy Population-A Longitudinal Cohort Study in South Korea
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE social trust; metabolic syndrome
ID DEPRESSION; OVERWEIGHT; MORTALITY; COHESION; OBESITY; DISEASE; IMPACT;
   WOMEN; RISK; MEN
AB Background:Social trust, assessed by the trustworthiness of one another in a community, is known to have beneficial effects on health outcomes. However, the impact of social trust on metabolic syndrome (MetS) is unclear.Methods:The study subjects were extracted from the Korean National Health Insurance Service, and social trust was obtained from the Korean Community Health Survey (KCHS). Previously healthy participants were followed up from 1 January 2010 to 31 December 2011, and again from 1 January 2012 to 31 December 2013 for waist circumference, blood pressure, fasting blood glucose, triglycerides and high-density lipoprotein cholesterol (HDL-C). Multivariate logistic regression was used to calculate the adjusted odds ratios (aORs) with 95% confidence intervals (CIs) for newly developed MetS according to social trust quintiles. Stratified analyses were performed to determine the relationship between lifestyle behaviors and social trust.Results:Compared to the participants within the first quintile of social trust, those in the remaining quintiles had lower risks of developing MetS. The aOR with the 95% CI was 0.88 (0.79-0.98) in the 5th quintile group of social trust. Among the diagnostic criteria for MetS, waist circumference and HDL-C were statistically significant with aORs of 0.91 (0.84-0.99) and 0.88 (0.80-0.95) in the 5th quintile group. The stratified analyses showed protective effects of positive lifestyle behaviors. The aORs with 95% CIs were 0.85 (0.74-0.99) in never smokers, 0.82 (0.70-0.95) in non-drinkers and 0.87 (0.76-1.00) in the physically active in the highest level of social trust.Conclusions: Higher social trust was associated with a lower incidence of MetS. Therefore, building community with psychosocial support may be helpful in improving public health.
C1 [Park, Hyeah; Kim, Kyae Hyung; Kang, EunKyo; Park, Sang Min] Seoul Natl Univ Hosp, Dept Family Med, Seoul 03080, South Korea.
   [Choi, Seulggie; Park, Sang Min] Seoul Natl Univ, Dept Biomed Sci, Grad Sch, Seoul 03080, South Korea.
   [Kim, Kyae Hyung; Kang, EunKyo; Ko, Ahryoung] Seoul Natl Univ Hosp, Inst Publ Hlth & Med Serv, Seoul 03080, South Korea.
C3 Seoul National University (SNU); Seoul National University Hospital;
   Seoul National University (SNU); Seoul National University (SNU); Seoul
   National University Hospital
RP Park, SM (corresponding author), Seoul Natl Univ Hosp, Dept Family Med, Seoul 03080, South Korea.; Park, SM (corresponding author), Seoul Natl Univ, Dept Biomed Sci, Grad Sch, Seoul 03080, South Korea.
EM hyeahp@snu.ac.kr; seulggie@gmail.com; truwhat@gmail.com;
   ekherb@naver.com; ahryoungko@gmail.com; smpark.snuh@gmail.com
RI Kim, Sang/J-5399-2012; Park, Sang/V-9194-2019
OI Kim, Kyae Hyung/0000-0001-9954-6422; Kang, EunKyo/0000-0001-5844-5625;
   Park, Sang Min/0000-0002-7498-4829; Ko, Ahryoung/0000-0001-8381-5595
FU Korean Centers for Disease Control and Prevention [2018P330400];
   BK21-Plus Education Program from the National Research Foundation of
   Korea
FX This research was supported by the Korean Centers for Disease Control
   and Prevention (grant number: 2018P330400). S. Choi received grants from
   the BK21-Plus Education Program from the National Research Foundation of
   Korea.
CR Abbott S, 2008, J HEALTH PSYCHOL, V13, P874, DOI 10.1177/1359105308095060
   Anand SS, 2019, LANCET PLANET HEALTH, V3, pE511, DOI 10.1016/S2542-5196(19)30237-2
   Baldock KL, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0201336
   Barber S, 2016, SOC SCI MED, V153, P107, DOI 10.1016/j.socscimed.2016.02.001
   Alvarez EC, 2017, GAC SANIT, V31, P57, DOI 10.1016/j.gaceta.2016.09.002
   Carrillo-Alvarez E, 2019, OBES REV, V20, P119, DOI 10.1111/obr.12760
   Cohen-Cline H, 2018, HEALTH PLACE, V50, P162, DOI 10.1016/j.healthplace.2018.02.002
   Firouzbakht M, 2019, CASP J INTERN MED, V10, P281, DOI 10.22088/cjim.10.3.281
   Giordano GN, 2019, J EPIDEMIOL COMMUN H, V73, P50, DOI 10.1136/jech-2018-211250
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Harpham T, 2002, HEALTH POLICY PLANN, V17, P106, DOI 10.1093/heapol/17.1.106
   Kamphuis CBM, 2019, BMC PUBLIC HEALTH, V19, DOI 10.1186/s12889-019-8007-3
   Kang Yang Wha, 2015, Osong Public Health Res Perspect, V6, P211, DOI 10.1016/j.phrp.2015.05.003
   Kim ES, 2013, SOC SCI MED, V97, P49, DOI 10.1016/j.socscimed.2013.08.001
   Kim K, 2018, EUR HEART J, V39, P1523, DOI 10.1093/eurheartj/ehx761
   Kim SA, 2020, EUR J NUTR, V59, P3023, DOI 10.1007/s00394-019-02141-y
   Lemmers-Jansen ILJ, 2017, DEV COGN NEUROS-NETH, V25, P235, DOI 10.1016/j.dcn.2017.02.001
   Mendenhall E, 2017, LANCET, V389, P951, DOI 10.1016/S0140-6736(17)30402-6
   Moore S, 2009, J PUBLIC HEALTH-UK, V31, P175, DOI 10.1093/pubmed/fdn104
   Moreno-Smith M, 2010, FUTURE ONCOL, V6, P1863, DOI [10.2217/fon.10.142, 10.2217/FON.10.142]
   Morgan A., 2011, REV PSICOL CRIANCA A, V2, P19
   Nieminen T, 2015, EUR J PUBLIC HEALTH, V25, P972, DOI 10.1093/eurpub/ckv058
   Pearce N, 2003, AM J PUBLIC HEALTH, V93, P122, DOI 10.2105/AJPH.93.1.122
   Rodgers J, 2019, SOC SCI MED, V236, DOI 10.1016/j.socscimed.2019.112360
   Seong SC, 2017, INT J EPIDEMIOL, V46, P799, DOI 10.1093/ije/dyw253
   Sherling DH, 2017, J CARDIOVASC PHARM T, V22, P365, DOI 10.1177/1074248416686187
   Sundararajan V, 2004, J CLIN EPIDEMIOL, V57, P1288, DOI 10.1016/j.jclinepi.2004.03.012
   Sundquist K, 2014, EXP GERONTOL, V55, P29, DOI 10.1016/j.exger.2014.03.007
   Villalonga-Olives E, 2017, SOC SCI MED, V194, P105, DOI 10.1016/j.socscimed.2017.10.020
   Wu YH, 2018, PREV MED, V111, P366, DOI 10.1016/j.ypmed.2017.11.028
   Xue XD, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4883-6
NR 31
TC 5
Z9 5
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD AUG
PY 2020
VL 17
IS 16
AR 5629
DI 10.3390/ijerph17165629
PG 12
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA NI5HA
UT WOS:000565381400001
PM 32764218
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rubenfire, M
   Mollo, L
   Krishnan, S
   Finkel, S
   Weintraub, M
   Gracik, T
   Kohn, D
   Oral, EA
AF Rubenfire, Melvyn
   Mollo, Lynette
   Krishnan, Sangeetha
   Finkel, Sandra
   Weintraub, Martha
   Gracik, Theresa
   Kohn, Daniel
   Oral, Elif A.
TI The Metabolic Fitness Program LIFESTYLE MODIFICATION FOR THE METABOLIC
   SYNDROME USING THE RESOURCES OF CARDIAC REHABILITATION
SO JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
LA English
DT Article
DE cardiac rehabilitation; lifestyle; modification; medical fitness
   program; metabolic syndrome
ID 3RD NATIONAL-HEALTH; WEIGHT-LOSS; SCIENTIFIC STATEMENT; CARDIOVASCULAR
   RISK; MEDITERRANEAN DIET; EXERCISE; INTERVENTION; PREVALENCE; NUTRITION;
   PREVENTION
AB PURPOSE: To describe and assess the effectiveness of a lifestyle intervention program (Met Fit) designed to treat the metabolic syndrome (MetSyn) in a cardiac rehabilitation setting.
   METHODS: Met Fit is a physician referred and patient pay ($350) program consisting of 12 weekly sessions of 45 minutes of exercise and 45 minutes of education with target exercise recommendations of 150 to 200 minutes weekly and 5% loss in body weight using a Mediterranean-style diet. Primary outcomes are compliance with program recommendations and secondary outcomes effecting MetSyn components.
   RESULTS: Patients (N = 126) were enrolled between June 2005 and July 2009 averaging 9 per class. Mean (SD) age was 51(12) years, body mass index 38(6.9) kg/m(2), high density lipoprotein-cholesterol for men 37(9.4) mg/dL and women 46(10) mg/dL, glucose 121(39) mg/dL, and homeostatic model assessment of insulin resistance 7.2(6.1). For the 93 (73.8%) patients for whom there was complete data, mean weight loss was 6.2(6.9) kg, 63.4% lost at least 4 kg, and 19.4% lost more than 5% of weight. Significant reductions were observed in the waist circumference and body fat, and systolic and diastolic blood pressure. Triglycerides decreased significantly in both diabetics and nondiabetics but glucose decreased significantly only in diabetics. At baseline, 51% had evidence of depression, which decreased to 24.7% at 12 weeks. At program completion, 18 patients (19.4%) no longer had the MetSyn and 39 (41.9%) lost at least 1 criterion (P < .0001).
   CONCLUSIONS: A 12-week patient-pay lifestyle interventional program conducted in a cardiac rehabilitation setting can result in a highly significant benefit to patients with the MetSyn.
C1 [Rubenfire, Melvyn; Mollo, Lynette; Krishnan, Sangeetha; Finkel, Sandra; Weintraub, Martha; Gracik, Theresa; Kohn, Daniel; Oral, Elif A.] Univ Michigan, Sch Med, Div Cardiovasc Med, Ann Arbor, MI USA.
C3 University of Michigan System; University of Michigan
RP Rubenfire, M (corresponding author), 24 Frank Lloyd Wright Dr,Lobby A,Ste 3700, Ann Arbor, MI 48106 USA.
EM mrubenfi@umich.edu
OI Oral, Elif/0000-0002-9171-1144
FU Cardiovascular Medicine Preventive Cardiology Research Fund
FX Funding: Cardiovascular Medicine Preventive Cardiology Research Fund.
   The authors declare no conflict of interest.
CR [Anonymous], JAMA
   Balady GJ, 2007, CIRCULATION, V115, P2675, DOI 10.1161/CIRCULATIONAHA.106.180945
   BOUCHARD C, 1995, MED SCI SPORT EXER, V27, P721
   CONNOR SL, 1992, J AM DIET ASSOC, V92, P41
   Das Sajal, 2006, Curr Atheroscler Rep, V8, P111, DOI 10.1007/s11883-006-0048-2
   Dowell AC, 1996, FAM PRACT, V13, P357, DOI 10.1093/fampra/13.4.357
   Draper T, 2007, J AM COLL CARDIOL, V49, p389A
   Eriksson KM, 2006, SCAND J PUBLIC HEALT, V34, P453, DOI 10.1080/14034940500489826
   Estruch R, 2006, ANN INTERN MED, V145, P1, DOI 10.7326/0003-4819-145-1-200607040-00004
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Hamman RF, 2006, DIABETES CARE, V29, P2102, DOI 10.2337/dc06-0560
   Hollis JF, 2008, AM J PREV MED, V35, P118, DOI 10.1016/j.amepre.2008.04.013
   Jakicic JM, 2003, JAMA-J AM MED ASSOC, V290, P1323, DOI 10.1001/jama.290.10.1323
   Katzmarzyk PT, 2003, MED SCI SPORT EXER, V35, P1703, DOI 10.1249/01.MSS.0000089337.73244.9B
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Knowler William C, 2002, N Engl J Med, V346, P393, DOI 10.1056/NEJMoa012512
   Lavie Carl J, 2005, J Cardiopulm Rehabil, V25, P59, DOI 10.1097/00008483-200503000-00001
   Li CY, 2009, DIABETES CARE, V32, P342, DOI 10.2337/dc08-1128
   Lloyd-Jones D, 2009, CIRCULATION, V119, pE21, DOI 10.1161/CIRCULATIONAHA.108.191261
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Martínez-González MA, 2008, BMJ-BRIT MED J, V336, P1348, DOI 10.1136/bmj.39561.501007.BE
   Marwick TH, 2009, CIRCULATION, V119, P3244, DOI 10.1161/CIRCULATIONAHA.109.192521
   Nichols GA, 2008, AM J MANAG CARE, V14, P791
   PROCHASKA JO, 1983, J CONSULT CLIN PSYCH, V51, P390, DOI 10.1037//0022-006X.51.3.390
   Schröder H, 2004, J NUTR, V134, P3355, DOI 10.1093/jn/134.12.3355
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Skinner JS, 2001, J APPL PHYSIOL, V90, P1770, DOI 10.1152/jappl.2001.90.5.1770
   Stewart KJ, 2005, AM J PREV MED, V28, P9, DOI 10.1016/j.amepre.2004.09.006
   Svetkey LP, 2008, JAMA-J AM MED ASSOC, V299, P1139, DOI 10.1001/jama.299.10.1139
   Svetkey LP, 2005, J HUM HYPERTENS, V19, P21, DOI 10.1038/sj.jhh.1001770
   Tjonna AE, 2008, CIRCULATION, V118, P346, DOI 10.1161/CIRCULATIONAHA.108.772822
   Wallace TM, 2004, DIABETES CARE, V27, P1487, DOI 10.2337/diacare.27.6.1487
   Wildman RP, 2008, ARCH INTERN MED, V168, P1617, DOI 10.1001/archinte.168.15.1617
   Woolf SH, 2009, JAMA-J AM MED ASSOC, V301, P536, DOI 10.1001/jama.2009.51
NR 37
TC 22
Z9 23
U1 2
U2 17
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1932-7501
EI 1932-751X
J9 J CARDIOPULM REHABIL
JI J. Cardiopulm. Rehabil. Prev.
PD SEP-OCT
PY 2011
VL 31
IS 5
BP 282
EP 289
DI 10.1097/HCR.0b013e318220a7eb
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 818OX
UT WOS:000294764000003
PM 21734589
OA Bronze
DA 2025-06-11
ER

PT J
AU Dushkin, M
   Khrapova, M
   Kovshik, G
   Chasovskikh, M
   Menshchikova, E
   Trufakin, V
   Shurlygina, A
   Vereschagin, E
AF Dushkin, Michael
   Khrapova, Marina
   Kovshik, Gennadiy
   Chasovskikh, Marina
   Menshchikova, Elena
   Trufakin, Valeriy
   Shurlygina, Anna
   Vereschagin, Evgeniy
TI Effects of rhaponticum carthamoides versus glycyrrhiza glabra and punica
   granatum extracts on metabolic syndrome signs in rats
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE Rhaponticum carthamoides; Metabolic syndrome; Corticosterone;
   Inflammatory cytokines
ID HIGH-FAT DIET; LEUZEA-CARTHAMOIDES; STATIN COMBINATION; CITRUS-SINENSIS;
   MICE; INSULIN; 20-HYDROXYECDYSONE; POMEGRANATE; LEVEL; FRUIT
AB Background: Rhaponticum cathamoides (RC) is an endemic wild Siberian herb with marked medicinal properties that are still poorly understood. The aim of this study is to investigate the therapeutic potential of RC extract (ERC) compared to the effects of Glycyrrhiza glabra (EGG) and Punica granatum extracts (EPG) in a rat model with high-fat diet-(HFD)-induced signs of metabolic syndrome; therefore, this study addresses a significant global public health problem.
   Methods: Six-month-old male Wistar Albino Glaxo rats were subjected to eight weeks of a standard diet (SD), HFD, or HFD in which ERC, EGG, or EPG powders were incorporated at 300 mg/kg/day. The serum lipid profile, corticosterone and cytokine concentrations, glucose tolerance, systolic blood pressure, triacylglycerol accumulation, and PPAR alpha DNA-binding activities in the liver samples were determined.
   Results: In contrast to EGG and EPG, an ERC supplement significantly reduced the weight of epididymal tissue (19.0%, p < 0.01) and basal serum glucose level (19.4%, p < 0.05). ERC improved glucose intolerance as well as dyslipidemia more efficiently than EGG and EPG. EGG but not ERC or EPG supplementation decreased systolic blood pressure by 12.0% (p < 0.05). All of the tested extracts reduced serum IL6 and corticosterone levels induced by HFD. However, the lowering effects of ERC consumption on the serum TNF-alpha level and its restoring effect on the adrenal corticosterone level significantly exceeded the improvements induced by EGG and EPG. ERC intake also reduced triacylglycerol accumulation and increased the PPAR alpha DNA-binding activity in the liver more significantly than EGG and EPG.
   Conclusions: ERC powder supplementation improved glucose and lipid metabolism more significantly than EGG and EPG in rats fed on HFD, supporting the strategy of R. carthamoides use for safe relief of metabolic syndrome and its related disturbances such as inflammation, stress, and hepatic steatosis.
C1 [Dushkin, Michael; Khrapova, Marina; Chasovskikh, Marina; Vereschagin, Evgeniy] Russian Acad Med Sci, Inst Internal Med, Siberian Branch, Lab Mol & Cellular Mech Therapeut Dis, Novosibirsk, Russia.
   [Dushkin, Michael; Kovshik, Gennadiy; Trufakin, Valeriy; Shurlygina, Anna] Russian Acad Med Sci, Siberian Branch, Inst Physiol & Fundamental Med, Novosibirsk, Russia.
   [Menshchikova, Elena] Russian Acad Med Sci, Siberian Branch, Ctr Clin & Expt Med, Novosibirsk, Russia.
C3 Russian Academy of Medical Sciences; Russian Academy of Sciences;
   Siberian Branch of the Russian Academy of Sciences; Russian Academy of
   Sciences; Siberian Branch of the Russian Academy of Sciences; Russian
   Academy of Medical Sciences; Research Institute for Neurosciences &
   Medicine; Russian Academy of Medical Sciences; Russian Academy of
   Sciences; Siberian Branch of the Russian Academy of Sciences
RP Dushkin, M (corresponding author), Russian Acad Med Sci, Inst Internal Med, Siberian Branch, Lab Mol & Cellular Mech Therapeut Dis, Novosibirsk, Russia.
EM midushkin@soramn.ru
RI Khrapova, Marina/U-5456-2019; Menshchikova, Elena/N-2062-2015
OI Menshchikova, Elena/0000-0003-2367-0114; Khrapova,
   Marina/0000-0003-3397-8067; Trufakin, Valeriy/0000-0002-8059-1108
FU Russian Foundation for Basic Research [11-04-00555a]
FX This study was supported by the Russian Foundation for Basic Research
   (11-04-00555a). The authors wish to thank Prof. Vera Selyatitskaya for
   corticosterone measurement assistance.
CR Al-Muammar MN, 2012, NUTRITION, V28, P595, DOI 10.1016/j.nut.2011.11.013
   Anagnostis P, 2009, J CLIN ENDOCR METAB, V94, P2692, DOI 10.1210/jc.2009-0370
   Babish JG, 2010, J MED FOOD, V13, P535, DOI 10.1089/jmf.2009.0110
   Celik MM, 2012, HUM EXP TOXICOL, V31, P1295, DOI 10.1177/0960327112446843
   Cherniack EP, 2011, NUTRITION, V27, P617, DOI 10.1016/j.nut.2010.10.013
   Del Ben M, 2012, INTERN EMERG MED, V7, pS291, DOI 10.1007/s11739-012-0819-4
   Eu CHA, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-81
   Filippatos TD, 2012, CARDIOVASC DRUG THER, V26, P245, DOI 10.1007/s10557-012-6394-0
   Fu JH, 2009, EXP CLIN ENDOCR DIAB, V117, P354, DOI 10.1055/s-0028-1119406
   HARA A, 1978, ANAL BIOCHEM, V90, P420, DOI 10.1016/0003-2697(78)90046-5
   Honda K, 2009, ANIM SCI J, V80, P562, DOI 10.1111/j.1740-0929.2009.00670.x
   Huang THW, 2009, PHARMACOL RES, V60, P195, DOI 10.1016/j.phrs.2009.03.020
   Jungbauer A, 2014, J STEROID BIOCHEM, V139, P277, DOI 10.1016/j.jsbmb.2012.12.009
   Kang XQ, 2009, HEPATOLOGY, V50, P1241, DOI 10.1002/hep.23090
   King-Jones K, 2005, NAT REV GENET, V6, P311, DOI 10.1038/nrg1581
   Kizelsztein P, 2009, AM J PHYSIOL-ENDOC M, V296, pE433, DOI 10.1152/ajpendo.90772.2008
   Kokoska L, 2009, PHYTOCHEMISTRY, V70, P842, DOI 10.1016/j.phytochem.2009.04.008
   Koleckar V, 2010, J ENZYM INHIB MED CH, V25, P143, DOI 10.3109/14756360903090970
   Kumpun S, 2011, J STEROID BIOCHEM, V126, P1, DOI 10.1016/j.jsbmb.2011.03.016
   Laksmidevi N, 2011, INT J PHARM BIOMED S, V2, P65
   Liu Na, 2010, Chinese Medical Sciences Journal, V25, P237, DOI 10.1016/S1001-9294(11)60009-6
   Medjakovic S, 2013, FOOD FUNCT, V4, P19, DOI 10.1039/c2fo30034f
   Michos ED, 2012, J AM COLL CARDIOL, V59, P2058, DOI 10.1016/j.jacc.2012.01.045
   MIRONOVA VN, 1982, VOP MED KHIM, V28, P101
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Nakagawa K, 2004, BIOL PHARM BULL, V27, P1775, DOI 10.1248/bpb.27.1775
   Nosál R, 2011, PHARMACOL REP, V63, P790, DOI 10.1016/S1734-1140(11)70591-6
   Nseir W, 2012, DIGEST DIS SCI, V57, P1773, DOI 10.1007/s10620-012-2118-3
   Panichayupakaranant P, 2010, PHARM BIOL, V48, P201, DOI 10.3109/13880200903078503
   Parmar HS, 2007, BIOFACTORS, V31, P17, DOI 10.1002/biof.5520310102
   Parmar HS, 2008, J MED FOOD, V11, P376, DOI 10.1089/jmf.2006.010
   Pereira MA, 2009, INT J ENV RES PUB HE, V6, P2568, DOI 10.3390/ijerph6102568
   Peschel W, 2011, J PHARM PHARMACOL, V63, P1483, DOI 10.1111/j.2042-7158.2011.01349.x
   Plotnikov M. B., 2011, Eksperimental'naya i Klinicheskaya Farmakologiya, V74, P7
   Power M, 2011, CURR DIABETES REP, V11, P173, DOI 10.1007/s11892-011-0184-0
   Prasad H, 2012, POSTGRAD MED, V124, P21, DOI 10.3810/pgm.2012.01.2514
   Pratchayasakul W, 2011, LIFE SCI, V88, P619, DOI 10.1016/j.lfs.2011.02.003
   Scarpellini E, 2012, DIGEST DIS, V30, P148, DOI 10.1159/000336664
   Seidlova-Wuttke D, 2010, J STEROID BIOCHEM, V119, P121, DOI 10.1016/j.jsbmb.2010.01.006
   STEINEGER HH, 1994, EUR J BIOCHEM, V225, P967, DOI 10.1111/j.1432-1033.1994.0967b.x
   Wang S, 2010, J MOL CELL BIOL, V2, P128, DOI 10.1093/jmcb/mjq006
NR 41
TC 17
Z9 18
U1 0
U2 21
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD JAN 20
PY 2014
VL 14
AR 33
DI 10.1186/1472-6882-14-33
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA AA5FY
UT WOS:000331122700001
PM 24444255
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU McInerney, M
   Winecoff, R
   Ayyagari, P
   Simon, K
   Bundorf, MK
AF McInerney, Melissa
   Winecoff, Ruth
   Ayyagari, Padmaja
   Simon, Kosali
   Bundorf, M. Kate
TI ACA Medicaid Expansion Associated With Increased Medicaid Participation
   and Improved Health Among Near-Elderly: Evidence From the Health and
   Retirement Study
SO INQUIRY-THE JOURNAL OF HEALTH CARE ORGANIZATION PROVISION AND FINANCING
LA English
DT Article
DE Patient Protection and Affordable Care Act; Medicaid; insurance
   coverage; health status; crowd-out; near-elderly adults;
   difference-in-differences
ID AFFORDABLE CARE ACT; 1ST 2 YEARS; INSURANCE-COVERAGE; CHILDLESS ADULTS;
   MENTAL-HEALTH; ACCESS; BEHAVIORS; DECLINE; IMPACT; DEATH
AB The Affordable Care Act (ACA) dramatically expanded health insurance, but questions remain regarding its effects on health. We focus on older adults for whom health insurance has greater potential to improve health and well-being because of their greater health care needs relative to younger adults. We further focus on low-income adults who were the target of the Medicaid expansion. We believe our study provides the first evidence of the health-related effects of ACA Medicaid expansion using the Health and Retirement Study (HRS). Using geo-coded data from 2010 to 2016, we estimate difference-in-differences models, comparing changes in outcomes before and after the Medicaid expansion in treatment and control states among a sample of over 3,000 unique adults aged 50 to 64 with income below 100% of the federal poverty level. The HRS allows us to examine morbidity outcomes not available in administrative data, providing evidence of the mechanisms underlying emerging evidence of mortality reductions due to expanded insurance coverage among the near-elderly. We find that the Medicaid expansion was associated with a 15 percentage point increase in Medicaid coverage which was largely offset by declines in other types of insurance. We find improvements in several measures of health including a 12% reduction in metabolic syndrome; a 32% reduction in complications from metabolic syndrome; an 18% reduction in the likelihood of gross motor skills difficulties; and a 34% reduction in compromised activities of daily living (ADLs). Our results thus suggest that the Medicaid expansion led to improved physical health for low-income, older adults.
C1 [McInerney, Melissa] Tufts Univ, Dept Econ, Medford, MA 02155 USA.
   [Winecoff, Ruth; Simon, Kosali] Indiana Univ, Bloomington, IN USA.
   [Ayyagari, Padmaja] Univ S Florida, Tampa, FL 33620 USA.
   [Bundorf, M. Kate] Stanford Univ, Stanford, CA 94305 USA.
C3 Tufts University; Indiana University System; Indiana University
   Bloomington; State University System of Florida; University of South
   Florida; Stanford University
RP McInerney, M (corresponding author), Tufts Univ, Braker Hall,8 Upper Campus Rd, Medford, MA 02155 USA.
EM melissa.mcinerney@tufts.edu
OI McInerney, Melissa/0000-0002-3064-8313; simon,
   kosali/0000-0002-3231-1466; Bundorf, M. Kate/0000-0002-9824-4868
FU National Institute on Aging [R03 AG059110]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This
   research was supported by R03 AG059110 from the National Institute on
   Aging.
CR [Anonymous], 2016, Making eye health a population health imperative: vision for tomorrow
   [Anonymous], 2020, Status of State Action on the Medicaid Expansion Decision
   Ayyagari P, 2015, J HEALTH ECON, V41, P46, DOI 10.1016/j.jhealeco.2015.01.006
   Baker DW, 2006, MED CARE, V44, P277, DOI 10.1097/01.mlr.0000199696.41480.45
   Baker DW, 2001, NEW ENGL J MED, V345, P1106, DOI 10.1056/NEJMsa002887
   Bernard DM, 2016, MED CARE, V54, P243, DOI 10.1097/MLR.0000000000000508
   Brevoort K., 2017, Medicaid and Financial Health, DOI [10.3386/w24002, DOI 10.3386/W24002]
   Burns M, 2017, J PUBLIC ECON, V149, P20, DOI 10.1016/j.jpubeco.2017.03.004
   Card D, 2009, Q J ECON, V124, P597, DOI 10.1162/qjec.2009.124.2.597
   Card D, 2008, AM ECON REV, V98, P2242, DOI 10.1257/aer.98.5.2242
   Case A, 2015, P NATL ACAD SCI USA, V112, P15078, DOI 10.1073/pnas.1518393112
   Caswell KJ, 2019, MED CARE RES REV, V76, P538, DOI 10.1177/1077558717725164
   Cawley J, 2018, J GEN INTERN MED, V33, P1495, DOI 10.1007/s11606-018-4537-0
   Courtemanche C, 2019, HEALTH SERV RES, V54, P307, DOI 10.1111/1475-6773.13077
   Courtemanche C, 2018, INQUIRY-J HEALTH CAR, V55, DOI 10.1177/0046958018796361
   Courtemanche C, 2018, SOUTH ECON J, V84, P660, DOI 10.1002/soej.12245
   Dunn A, 2019, AM J HEALTH ECON, V5, P126, DOI 10.1162/ajhe_a_00107
   Fowler-Brown A, 2007, J GEN INTERN MED, V22, P502, DOI 10.1007/s11606-007-0127-2
   Ghosh A, 2019, J HEALTH ECON, V63, P64, DOI 10.1016/j.jhealeco.2018.11.002
   Glied S., 2017, How Medicaid expansion affected out-of-pocket health care spending for low-income families
   Goldin J., 2019, National Bureau of Economic Research Working Paper Series
   Gruber J, 2019, J POLICY ANAL MANAG, V38, P1028, DOI 10.1002/pam.22158
   Guth M, 2020, EFFECTS MEDICAID EXP
   Hu LJ, 2018, J PUBLIC ECON, V163, P99, DOI 10.1016/j.jpubeco.2018.04.009
   Huh J, 2017, J HEALTH ECON, V53, P17, DOI 10.1016/j.jhealeco.2017.01.005
   Kaiser Family Foundation, 2020, PREM COST SHAR REQ S
   Kaiser Family Foundation, 2018, MED BEN DENT SERV
   Khatana SAM, 2019, JAMA CARDIOL, V4, P671, DOI 10.1001/jamacardio.2019.1651
   McMorrow S, 2017, HEALTH AFFAIR, V36, P808, DOI 10.1377/hlthaff.2016.1650
   McWilliams JM, 2004, HEALTH AFFAIR, V23, P223, DOI 10.1377/hlthaff.23.4.223
   Metabolic syndrome, 2019, MET SYNDR COND INCL
   Miller S., 2019, 26081 NBER, DOI [10.3386/w26081, DOI 10.3386/W26081]
   Miller S., 2018, ACA MED EXPANSION MI
   Miller S, 2019, AEA PAP P, V109, P327, DOI 10.1257/pandp.20191046
   Miller S, 2017, NEW ENGL J MED, V376, P947, DOI 10.1056/NEJMsa1612890
   Simon K, 2017, J POLICY ANAL MANAG, V36, P390, DOI 10.1002/pam.21972
   Smolka G., 2012, Health Insurance Coverage for 50-to 64-Year-Olds
   Sojourner A., 2017, Health Affairs Blog, DOI DOI 10.1377/FOREFRONT.20170724.061160/FULL
   Sommers BD, 2017, HEALTH AFFAIR, V36, P1119, DOI 10.1377/hlthaff.2017.0293
   Sommers BD, 2016, JAMA INTERN MED, V176, P1501, DOI 10.1001/jamainternmed.2016.4419
   Sommers BD, 2015, JAMA-J AM MED ASSOC, V314, P366, DOI 10.1001/jama.2015.8421
   Swaminathan S, 2018, JAMA-J AM MED ASSOC, V320, P2242, DOI 10.1001/jama.2018.16504
   Tarazi WW, 2018, AM J PREV MED, V55, P624, DOI 10.1016/j.amepre.2018.06.020
   U.S. Census Bureau, 2015, HLTH INSURANCE COVER, P60
   Wallace RB, 1995, J HUM RESOUR, V30, pS84, DOI 10.2307/146279
   Ward EM, 2010, CANCER J, V16, P614, DOI 10.1097/PPO.0b013e3181ff2aec
   Wehby GL, 2018, HEALTH SERV RES, V53, P1248, DOI 10.1111/1475-6773.12711
   Wherry LR, 2016, ANN INTERN MED, V164, P795, DOI 10.7326/M15-2234
   Wing C, 2018, ANNU REV PUBL HEALTH, V39, P453, DOI 10.1146/annurev-publhealth-040617-013507
   Winkelman TNA, 2018, J GEN INTERN MED, V33, P376, DOI 10.1007/s11606-017-4217-5
NR 50
TC 16
Z9 19
U1 1
U2 14
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0046-9580
EI 1945-7243
J9 INQUIRY-J HEALTH CAR
JI Inquiry-J. Health Care Organ. Provis. Financ.
PD JUL
PY 2020
VL 57
AR 0046958020935229
DI 10.1177/0046958020935229
PG 10
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA MV8WW
UT WOS:000556632000001
PM 32720837
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Korac, B
   Kalezic, A
   Pekovic-Vaughan, V
   Korac, A
   Jankovic, A
AF Korac, Bato
   Kalezic, Andjelika
   Pekovic-Vaughan, Vanja
   Korac, Aleksandra
   Jankovic, Aleksandra
TI Redox changes in obesity, metabolic syndrome, and diabetes
SO REDOX BIOLOGY
LA English
DT Article
DE Redox biomarkers; Obesity; Metabolic syndrome; Diabetes; Lipofuscin;
   NRF2; Circadian rhythms; Cancer
ID DIET-INDUCED OBESITY; FREE FATTY-ACIDS; BODY-MASS INDEX; SYSTEMIC
   OXIDATIVE STRESS; PROTEIN CARBONYL LEVELS; GLYCATION END-PRODUCT;
   BREAST-CANCER RISK; ADIPOSE-TISSUE; INSULIN-RESISTANCE; NITRIC-OXIDE
AB "Life is an instantaneous encounter of circulating matter and flowing energy" (Jean Giaja, Serbian physiologist), is one of the most elegant definitions not only of life but the relationship of redox biology and metabolism. Their evolutionary liaison has created inseparable yet dynamic homeostasis in health, which, when disrupted, leads to disease. This interconnection is even more pertinent today, in an era of increasing metabolic diseases of epidemic proportions such as obesity, metabolic syndrome, and diabetes. Despite great advances in understanding the molecular mechanisms of redox and metabolic regulation, we face significant challenges in preventing, diagnosing, and treating metabolic diseases. The etiological association and temporal overlap of these syndromes present significant challenges for the discrimination of appropriate clinical biomarkers for diagnosis, treatment, and outcome prediction. These multifactorial, multiorgan metabolic syndromes with complex etiopathogenic mechanisms are accompanied by disturbed redox equilibrium in target tissues and circulation. Free radicals and reactive species are considered both a causal factor and a consequence of disease status. Thus, determining the subtypes and levels of free radicals and reactive species, oxidatively damaged biomolecules (lipids, proteins, and nucleic acids) and antioxidant defense components as well as redox-sensitive transcription factors and fluxes of redox-dependent metabolic pathways will help define existing and establish novel redox biomarkers for stratifying metabolic diseases. This review aims to discuss diverse redox/metabolic aspects in obesity, metabolic syndrome, and diabetes, with the imperative to help establish a platform for emerging and future redoxmetabolic biomarkers research in precision medicine. Future research warrants detailed investigations into the status of redox biomarkers in healthy subjects and patients, including the use of emerging 'omic' profiling technologies (e.g., redox proteomes, lipidomes, metabolomes, and transcriptomes), taking into account the influence of lifestyle (diet, physical activity, sleep, work patterns) as well as circadian similar to 24h fluctuations in circulatory factors and metabolites.
C1 [Korac, Bato; Kalezic, Andjelika; Jankovic, Aleksandra] Univ Belgrade, Inst Biol Res Sinisa Stankovic, Dept Physiol, Natl Inst Republ Serbia, Belgrade 11000, Serbia.
   [Korac, Bato; Korac, Aleksandra] Univ Belgrade, Fac Biol, Ctr Electron Microscopy, Belgrade 11000, Serbia.
   [Pekovic-Vaughan, Vanja] Univ Liverpool, Fac Hlth & Life Sci, Inst Life Course & Med Sci, William Henry Duncan Bldg, Liverpool L7 8TX, England.
C3 University of Belgrade; University of Belgrade; University of Liverpool
RP Korac, B; Jankovic, A (corresponding author), Univ Belgrade, Natl Inst Republ Serbia, Inst Biol Res Sinisa Stankovic, Bulevar Despota Stefana 142, Belgrade 11000, Serbia.
EM koracb@ibiss.bg.ac.rs; aleksandra.jankovic@ibiss.bg.ac.rs
RI Korac, Bato/AAH-8206-2021; Kalezic, Andjelika/AAX-9082-2021; Jankovic,
   Aleksandra/ACV-5778-2022
OI Kalezic, Andjelika/0000-0002-2066-9137; Pekovic-Vaughan,
   Vanja/0000-0002-7876-652X; Jankovic, Aleksandra/0000-0002-6945-927X;
   Korac, Bato/0000-0001-5272-579X
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [451-03-68/2020-14/200007, 451-03-68/202014/200178];
   Science Fund of the Republic of Serbia, PROMIS [6066747]; MRC New
   Investigator Research Grant; Medical Research Council (MRC) Versus
   Arthritis Centre for Integrated Research on Musculoskeletal Ageing;
   Rosetrees Trust; Wellcome Trust Institutional Strategic Fund Fellowship;
   BBSRC [BB/W010801/1] Funding Source: UKRI; MRC [MR/P003311/1,
   MR/P020941/1] Funding Source: UKRI
FX The authors are grateful for the support from the Ministry of Education,
   Science and Technological Development of the Republic of Serbia [grant
   numbers 451-03-68/2020-14/200007 and 451-03-68/202014/200178] and the
   Science Fund of the Republic of Serbia, PROMIS [grant number 6066747] as
   well as from the MRC New Investigator Research Grant, the Medical
   Research Council (MRC) Versus Arthritis Centre for Integrated Research
   on Musculoskeletal Ageing, The Rosetrees Trust and Wellcome Trust
   Institutional Strategic Fund Fellowship (VPV) .
CR Abadi PA, 2020, DIABETES METAB SYND, V14, P11, DOI 10.1016/j.dsx.2019.11.014
   Abdolsamadi HR, 2015, INT J DIABETES DEV C, V35, pS477, DOI 10.1007/s13410-014-0207-x
   Adamska A, 2020, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00873
   Adler L, 2015, PROG MOL BIOL TRANSL, V134, pE1, DOI 10.1016/bs.pmbts.2015.07.022
   Adnan MT, 2019, DIABETES METAB SYND, V13, P933, DOI 10.1016/j.dsx.2018.12.022
   Agarwal A, 2016, DIABETES METAB SYND, V10, pS123, DOI 10.1016/j.dsx.2016.03.009
   Aleksunes LM, 2010, J PHARMACOL EXP THER, V333, P140, DOI 10.1124/jpet.109.162271
   Allaire J, 2002, MUSCLE NERVE, V25, P383, DOI 10.1002/mus.10039
   [Anonymous], 2015, IMMUNOENDOCRINOLOGY, DOI DOI 10.14800/IMMUNOENDOCRINOLOGY.657
   Arif M, 2010, DIABETES METAB, V36, P51, DOI 10.1016/j.diabet.2009.05.007
   Arnold M, 2015, LANCET ONCOL, V16, P36, DOI 10.1016/S1470-2045(14)71123-4
   Association AD, 2016, DIABETES CARE S1, V39, pS13
   Astaneie F, 2005, ARCH MED RES, V36, P376, DOI 10.1016/j.arcmed.2005.03.007
   Audrey D, 2014, FREE RADICAL BIO MED, V75, pS18, DOI 10.1016/j.freeradbiomed.2014.10.631
   Avgerinos KI, 2019, METABOLISM, V92, P121, DOI 10.1016/j.metabol.2018.11.001
   Axelsson AS, 2017, SCI TRANSL MED, V9, DOI 10.1126/scitranslmed.aah4477
   Bando Y, 2018, J MED INVEST, V65
   Barocas DA, 2011, J UROLOGY, V185, P2102, DOI 10.1016/j.juro.2011.02.020
   Bhaskaran K, 2014, LANCET, V384, P755, DOI 10.1016/S0140-6736(14)60892-8
   Blanco RA, 2007, AM J CLIN NUTR, V86, P1016, DOI 10.1093/ajcn/86.4.1016
   BODEN G, 1994, J CLIN INVEST, V93, P2438, DOI 10.1172/JCI117252
   Bonomini F, 2015, AGING DIS, V6, P109, DOI 10.14336/AD.2014.0305
   Bora S, 2020, DIABETES METAB SYND, V14, P1751, DOI 10.1016/j.dsx.2020.08.037
   Boyer F, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/534873
   Broussard JL, 2015, DIABETOLOGIA, V58, P791, DOI 10.1007/s00125-015-3500-4
   Brunk UT, 2002, FREE RADICAL BIO MED, V33, P611, DOI 10.1016/S0891-5849(02)00959-0
   Brunk UT, 2002, EUR J BIOCHEM, V269, P1996, DOI 10.1046/j.1432-1033.2002.02869.x
   Brys M, 2013, MOL CELL BIOCHEM, V372, P149, DOI 10.1007/s11010-012-1455-z
   Burlaka AP, 2018, BIOMED RES INT, V2018, DOI 10.1155/2018/2169036
   Çakatay U, 2005, DIABETES METAB, V31, P551, DOI 10.1016/S1262-3636(07)70230-6
   Calle EE, 2003, NEW ENGL J MED, V348, P1625, DOI 10.1056/NEJMoa021423
   Cazzola R, 2004, J LIPID RES, V45, P1846, DOI 10.1194/jlr.M300509-JLR200
   Cederroth CR, 2019, CELL METAB, V30, P238, DOI 10.1016/j.cmet.2019.06.019
   Cejvanovic V, 2016, SCAND J CLIN LAB INV, V76, P620, DOI 10.1080/00365513.2016.1230776
   Cervellati C, 2014, SCAND J CLIN LAB INV, V74, P102, DOI 10.3109/00365513.2013.860618
   Chaix A, 2019, CELL METAB, V29, P303, DOI 10.1016/j.cmet.2018.08.004
   Charoensin S, 2017, FREE RADICAL BIO MED, V102, P248, DOI 10.1016/j.freeradbiomed.2016.11.049
   Chartoumpekis DV, 2018, AM J PHYSIOL-ENDOC M, V315, pE180, DOI 10.1152/ajpendo.00311.2017
   Chartoumpekis DV, 2011, DIABETES, V60, P2465, DOI 10.2337/db11-0112
   Chistiakov DA, 2006, DIABETES METAB, V32, P63, DOI 10.1016/S1262-3636(07)70248-3
   Ciaraldi TP, 1995, J CLIN INVEST, V96, P2820, DOI 10.1172/JCI118352
   Claude B, 1865, INTRO ETUDE MED
   Conus F, 2007, APPL PHYSIOL NUTR ME, V32, P4, DOI 10.1139/h06-092
   Crujeiras AB, 2016, INT J OBESITY, V40, P514, DOI 10.1038/ijo.2015.208
   Cumbie BC, 2007, VASC HEALTH RISK MAN, V3, P823
   Dai Q, 2009, J CLIN ONCOL, V27, P2482, DOI 10.1200/JCO.2008.19.7970
   DANDONA P, 1984, DIABETOLOGIA, V27, P610, DOI 10.1007/BF00276981
   Davì G, 2002, JAMA-J AM MED ASSOC, V288, P2008, DOI 10.1001/jama.288.16.2008
   Davies SK, 2014, P NATL ACAD SCI USA, V111, P10761, DOI 10.1073/pnas.1402663111
   Depner CM, 2018, P NATL ACAD SCI USA, V115, pE5390, DOI 10.1073/pnas.1714813115
   Desco MC, 2002, DIABETES, V51, P1118, DOI 10.2337/diabetes.51.4.1118
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Di Francesco A, 2020, NPJ AGING MECH DIS, V6, DOI 10.1038/s41514-020-00051-6
   Di Meo S, 2017, J ENDOCRINOL, V233, pR15, DOI 10.1530/JOE-16-0598
   Dresner A, 1999, J CLIN INVEST, V103, P253, DOI 10.1172/JCI5001
   Dyar KA, 2017, FRONT NEUROSCI-SWITZ, V11, DOI 10.3389/fnins.2017.00369
   Dziaman T, 2014, INT J CANCER, V134, P376, DOI 10.1002/ijc.28374
   Early JO, 2018, P NATL ACAD SCI USA, V115, pE8460, DOI 10.1073/pnas.1800431115
   Edgar RS, 2012, NATURE, V485, P459, DOI 10.1038/nature11088
   ELGHAZZAWI EF, 1975, CELL TISSUE RES, V161, P555
   Elrayess MA, 2017, FREE RADICAL BIO MED, V104, P129, DOI 10.1016/j.freeradbiomed.2017.01.015
   Evangelou K, 2017, AGING CELL, V16, P192, DOI 10.1111/acel.12545
   Evans JL, 2002, ENDOCR REV, V23, P599, DOI 10.1210/er.2001-0039
   Feng FK, 2015, AGING CLIN EXP RES, V27, P573, DOI 10.1007/s40520-015-0326-3
   Festa A, 2001, INT J OBESITY, V25, P1407, DOI 10.1038/sj.ijo.0801792
   Flanagan A, 2021, J NEUROCHEM, V157, P53, DOI 10.1111/jnc.15246
   Förstermann U, 2012, EUR HEART J, V33, P829, DOI 10.1093/eurheartj/ehr304
   Forrestel AC, 2017, DIABETOLOGIA, V60, P808, DOI 10.1007/s00125-016-4175-1
   FRAZE E, 1985, J CLIN ENDOCR METAB, V61, P807, DOI 10.1210/jcem-61-5-807
   Frijhoff J, 2015, ANTIOXID REDOX SIGN, V23, P1144, DOI 10.1089/ars.2015.6317
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gào X, 2018, FREE RADICAL BIO MED, V123, P20, DOI 10.1016/j.freeradbiomed.2018.05.065
   García-Jiménez C, 2016, BRIT J CANCER, V114, P716, DOI 10.1038/bjc.2016.37
   García-Ramírez M, 2008, DIABETES METAB, V34, P117, DOI 10.1016/j.diabet.2007.10.011
   Géhl Z, 2016, REDOX BIOL, V9, P100, DOI 10.1016/j.redox.2016.07.003
   Giskeodegård GF, 2015, SCI REP-UK, V5, DOI 10.1038/srep14843
   Görlach A, 2015, REDOX BIOL, V6, P260, DOI 10.1016/j.redox.2015.08.010
   Gubin DG, 2017, CHRONOBIOL INT, V34, P1136, DOI 10.1080/07420528.2017.1347670
   Hacer IA, 2003, INT UROL NEPHROL, V36, P57
   Halliwell B, 2009, FREE RADICAL BIO MED, V46, P531, DOI 10.1016/j.freeradbiomed.2008.11.008
   Hamann A, 1996, ENDOCRINOLOGY, V137, P21, DOI 10.1210/en.137.1.21
   Han J, 2016, J LIPID RES, V57, P1329, DOI 10.1194/jlr.R067595
   Hanssen NMJ, 2017, DIABETES, V66, P2278, DOI 10.2337/db16-1578
   Hauck AK, 2016, J LIPID RES, V57, P1976, DOI 10.1194/jlr.R066597
   Hayes JD, 2014, TRENDS BIOCHEM SCI, V39, P199, DOI 10.1016/j.tibs.2014.02.002
   HEGEDUS ZL, 1981, ARCH INT PHYSIOL BIO, V89, P393, DOI 10.3109/13813458109069489
   HEGEDUS ZL, 1985, CRIT CARE MED, V13, P155, DOI 10.1097/00003246-198503000-00003
   Henriksen EJ, 2011, FREE RADICAL BIO MED, V51, P993, DOI 10.1016/j.freeradbiomed.2010.12.005
   Hoque A, 2010, CANCER PREV RES, V3, P478, DOI 10.1158/1940-6207.CAPR-09-0201
   Hou YY, 2012, FREE RADICAL BIO MED, V52, P462, DOI 10.1016/j.freeradbiomed.2011.10.453
   Huang Y, 2012, CELL BIOSCI, V2, DOI 10.1186/2045-3701-2-40
   Imamura K, 2018, P NATL ACAD SCI USA, V115, P3646, DOI 10.1073/pnas.1719298115
   Isherwood CM, 2017, FASEB J, V31, P5557, DOI 10.1096/fj.201700323R
   JAIN SK, 1991, DIABETES, V40, P1241, DOI 10.2337/diabetes.40.10.1241
   Jain SK, 2010, ANTIOXID REDOX SIGN, V12, P1333, DOI 10.1089/ars.2009.2956
   Jankovic A, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/2471312
   Jankovic A, 2017, BRIT J PHARMACOL, V174, P1570, DOI 10.1111/bph.13498
   Jankovic A, 2014, METABOLISM, V63, P661, DOI 10.1016/j.metabol.2014.01.009
   Jornayvaz FR, 2012, CELL METAB, V15, P574, DOI 10.1016/j.cmet.2012.03.005
   Jors A, 2020, FREE RADICAL BIO MED, V155, P81, DOI 10.1016/j.freeradbiomed.2020.05.009
   Jung T, 2007, ANN NY ACAD SCI, V1119, P97, DOI 10.1196/annals.1404.008
   Kalezic A, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21249676
   Kalyanaraman B, 2018, REDOX BIOL, V15, P347, DOI 10.1016/j.redox.2017.12.012
   Kalyanaraman B, 2017, REDOX BIOL, V12, P833, DOI 10.1016/j.redox.2017.04.018
   Kaneki M, 2007, ANTIOXID REDOX SIGN, V9, P319, DOI 10.1089/ars.2006.1464
   Karbownik-Lewinska M, 2012, NEUROENDOCRINOL LETT, V33, P453
   Karelis AD, 2008, DIABETOLOGIA, V51, P1752, DOI 10.1007/s00125-008-1038-4
   Kawashima K, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18040866
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Kolbe I, 2019, MOL METAB, V30, P140, DOI 10.1016/j.molmet.2019.09.012
   Kolbe I, 2019, FASEB J, V33, P175, DOI 10.1096/fj.201800441R
   Kopp W, 2020, DIABET METAB SYND OB, V13, P4631, DOI 10.2147/DMSO.S280146
   Korac A, 2003, EUR J HISTOCHEM, V47, P241
   Krishnaiah SY, 2017, CELL METAB, V25, P961, DOI [10.1016/j.cmet.2017.03.019, 10.1016/j.cmet.2017.04.023]
   Kushwaha RS, 2017, INDIAN J CLIN BIOCHE, V32, P220, DOI 10.1007/s12291-016-0594-5
   Laurent V, 2019, MOL CANCER RES, V17, P821, DOI 10.1158/1541-7786.MCR-18-0748
   Le Guenno G, 2007, DIABETES RES CLIN PR, V77, P363, DOI 10.1016/j.diabres.2007.02.004
   Lee J, 2013, MOL CELL BIOL, V33, P2327, DOI 10.1128/MCB.01421-12
   Li PY, 2016, SCI REP-UK, V6, DOI 10.1038/srep22831
   Li YP, 2014, ASIAN PAC J CANCER P, V15, P10151, DOI 10.7314/APJCP.2014.15.23.10151
   Ligibel JA, 2014, J CLIN ONCOL, V32, P3568, DOI 10.1200/JCO.2014.58.4680
   Lin XL, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-71908-9
   Liu JJ, 2019, REDOX BIOL, V24, DOI 10.1016/j.redox.2019.101167
   Lou BW, 2020, REDOX BIOL, V37, DOI 10.1016/j.redox.2020.101723
   LOWELL BB, 1993, NATURE, V366, P740, DOI 10.1038/366740a0
   Lucotti P, 2006, AM J PHYSIOL-ENDOC M, V291, pE906, DOI 10.1152/ajpendo.00002.2006
   Ly LD, 2017, EXP MOL MED, V49, DOI 10.1038/emm.2016.157
   Madak-Erdogan Z, 2019, CANCER RES, V79, P2494, DOI 10.1158/0008-5472.CAN-18-2849
   Madreiter-Sokolowski CT, 2020, REDOX BIOL, V36, DOI 10.1016/j.redox.2020.101678
   Mahat RK, 2019, DIABETES METAB SYND, V13, P616, DOI 10.1016/j.dsx.2018.11.045
   Manna P, 2015, METAB SYNDR RELAT D, V13, P423, DOI 10.1089/met.2015.0095
   Manzella N, 2015, SCI REP-UK, V5, DOI 10.1038/srep13752
   Markelic M, 2013, HISTOL HISTOPATHOL, V28, P493, DOI 10.14670/HH-28.493
   Masania J, 2016, GLYCOCONJUGATE J, V33, P581, DOI 10.1007/s10719-016-9692-0
   Maulucci G, 2016, MOL ASPECTS MED, V49, P49, DOI 10.1016/j.mam.2016.03.001
   Meher AK, 2012, FREE RADICAL BIO MED, V52, P1708, DOI 10.1016/j.freeradbiomed.2012.02.022
   Miles JM, 2003, DIABETES, V52, P675, DOI 10.2337/diabetes.52.3.675
   Montes-Nieto R, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201700425
   Monzo-Beltran L, 2017, REDOX BIOL, V12, P389, DOI 10.1016/j.redox.2017.02.003
   Moreno-García A, 2018, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00464
   Morgan JA, 2018, LANCET GASTROENTEROL, V3, P884, DOI 10.1016/S2468-1253(18)30347-9
   Mota MC, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-06723-w
   Murlikiewicz L, 2018, ADV CLIN EXP MED, V27, P77, DOI 10.17219/acem/67819
   Nagata N, 2017, DIABETES, V66, P1222, DOI 10.2337/db16-0662
   Nass N, 2017, HISTOCHEM CELL BIOL, V147, P625, DOI 10.1007/s00418-016-1534-4
   Neel BA, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00393
   Nishida C, 2010, EUR J CLIN NUTR, V64, P2, DOI 10.1038/ejcn.2009.139
   O'Flanagan CH, 2017, NPJ BREAST CANCER, V3, DOI 10.1038/s41523-017-0027-5
   O'Grady NP, 2002, CLIN INFECT DIS, V35, P1281, DOI [10.1086/344188, 10.1086/502007]
   Pajares M, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/2450748
   Palmieri VO, 2006, J NUTR, V136, P3022, DOI 10.1093/jn/136.12.3022
   Pande D, 2013, UROL ONCOL-SEMIN ORI, V31, P1561, DOI 10.1016/j.urolonc.2012.04.012
   Panieri E, 2016, CELL DEATH DIS, V7, DOI 10.1038/cddis.2016.105
   Pei JF, 2019, NAT CELL BIOL, V21, P1553, DOI 10.1038/s41556-019-0420-4
   Pekovic-Vaughan V, 2014, GENE DEV, V28, P548, DOI 10.1101/gad.237081.113
   Pi JB, 2010, J BIOL CHEM, V285, P9292, DOI 10.1074/jbc.M109.093955
   Pivovarova-Ramich O, 2020, REDOX BIOL, V29, DOI 10.1016/j.redox.2019.101397
   Poulsen HE, 2019, FREE RADICAL BIO MED, V145, P336, DOI 10.1016/j.freeradbiomed.2019.10.001
   Quail DF, 2019, NAT REV ENDOCRINOL, V15, P139, DOI 10.1038/s41574-018-0126-x
   Rabbani N, 2019, ANTIOXID REDOX SIGN, V30, P354, DOI 10.1089/ars.2017.7424
   Rains JL, 2011, FREE RADICAL BIO MED, V50, P567, DOI 10.1016/j.freeradbiomed.2010.12.006
   RANDLE PJ, 1963, LANCET, V1, P785
   Rasool M, 2018, FRONT ONCOL, V8, DOI 10.3389/fonc.2018.00205
   Ravussin E, 2002, ANN NY ACAD SCI, V967, P363
   Reinke H, 2019, NAT REV MOL CELL BIO, V20, P227, DOI 10.1038/s41580-018-0096-9
   Renehan AG, 2008, LANCET, V371, P569, DOI 10.1016/S0140-6736(08)60269-X
   Rey G, 2016, CELL METAB, V24, P462, DOI 10.1016/j.cmet.2016.07.024
   Rizou SV, 2019, METHODS MOL BIOL, V1896, P119, DOI 10.1007/978-1-4939-8931-7_12
   Roden M, 1996, J CLIN INVEST, V97, P2859, DOI 10.1172/JCI118742
   Rossner P, 2006, CANCER EPIDEM BIOMAR, V15, P639, DOI 10.1158/1055-9965.EPI-05-0554
   Rossner P, 2007, J CELL MOL MED, V11, P1138, DOI 10.1111/j.1582-4934.2007.00097.x
   Ruderman N, 1998, DIABETES, V47, P699, DOI 10.2337/diabetes.47.5.699
   RUDERMAN NB, 1981, AM J CLIN NUTR, V34, P1617, DOI 10.1093/ajcn/34.8.1617
   Salmon AB, 2016, ANTIOXIDANTS-BASEL, V5, DOI 10.3390/antiox5030024
   Sani M, 2015, REDOX REP, V20, DOI 10.1179/1351000214Y.0000000102
   Schmatz R, 2017, CLIN CHIM ACTA, V465, P72, DOI 10.1016/j.cca.2016.12.012
   Seo HA, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/184598
   Shao BL, 2014, REDOX BIOL, V2, P694, DOI 10.1016/j.redox.2014.05.005
   Sharma M, 2016, DIABETES METAB SYND, V10, P194, DOI 10.1016/j.dsx.2016.06.006
   Shen J, 2009, INT J CANCER, V124, P1637, DOI 10.1002/ijc.24105
   Shikata K, 2013, CANCER SCI, V104, P9, DOI 10.1111/cas.12043
   Shimabukuro M, 1998, P NATL ACAD SCI USA, V95, P2498, DOI 10.1073/pnas.95.5.2498
   Shin MJ, 2006, INT J OBESITY, V30, P1529, DOI 10.1038/sj.ijo.0803304
   Shin S, 2007, MOL CELL BIOL, V27, P7188, DOI 10.1128/MCB.00915-07
   Shin S, 2009, EUR J PHARMACOL, V620, P138, DOI 10.1016/j.ejphar.2009.08.022
   SOHAL RS, 1981, EXP GERONTOL, V16, P347, DOI 10.1016/0531-5565(81)90055-3
   Solinas G, 2010, FASEB J, V24, P2596, DOI 10.1096/fj.09-151340
   Soumura M, 2010, BIOCHEM BIOPH RES CO, V402, P265, DOI 10.1016/j.bbrc.2010.10.012
   Sova H, 2010, BRIT J CANCER, V102, P1018, DOI 10.1038/sj.bjc.6605565
   Stenvers DJ, 2019, NAT REV ENDOCRINOL, V15, P75, DOI 10.1038/s41574-018-0122-1
   Su HX, 2008, AGE, V30, P1, DOI 10.1007/s11357-007-9042-z
   Sullivan SA, 2017, GYNECOL ONCOL, V145, P21, DOI 10.1016/j.ygyno.2017.03.064
   Suzana S, 2008, ASIAN PAC J CANCER P, V9, P343
   Takahashi T, 2009, BIOCHEM BIOPH RES CO, V382, P549, DOI 10.1016/j.bbrc.2009.03.059
   TANNER LI, 1989, J CELL BIOL, V108, P1537, DOI 10.1083/jcb.108.4.1537
   Teixeira KRC, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-40989-6
   Terman A, 1999, EXP GERONTOL, V34, P943, DOI 10.1016/S0531-5565(99)00070-4
   Terman A, 2004, INT J BIOCHEM CELL B, V36, P1400, DOI 10.1016/j.biocel.2003.08.009
   Terman A, 1999, EXP GERONTOL, V34, P755, DOI 10.1016/S0531-5565(99)00045-5
   Tessari P, 2010, DIABETES, V59, P2152, DOI 10.2337/db09-1772
   Thakkar B, 2013, METABOLISM, V62, P922, DOI 10.1016/j.metabol.2013.01.014
   Thomas DD, 2019, J ENDOCR SOC, V3, P1727, DOI 10.1210/js.2019-00065
   Thornalley Paul J., 2008, Drug Metabolism and Drug Interactions, V23, P125
   Trent L, 2014, J ONCOL PRACT, V10, P119, DOI 10.1200/JOP.2014.001386
   Tsilidis KK, 2015, BMJ-BRIT MED J, V350, DOI 10.1136/bmj.g7607
   Unger RH, 2000, INT J OBESITY, V24, pS28, DOI 10.1038/sj.ijo.0801498
   VAGUE J, 1947, PRESSE MED, V55, P339
   Valacchi G, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00858
   Valacchi G, 2017, FREE RADICAL BIO MED, V111, P270, DOI 10.1016/j.freeradbiomed.2016.12.045
   Vasileva LV, 2020, PHARMACOL RES, V156, DOI 10.1016/j.phrs.2020.104760
   Vomhof-DeKrey EE, 2012, J NUTR BIOCHEM, V23, P1201, DOI 10.1016/j.jnutbio.2012.03.005
   Wang H., 2019, NAT COMMUNV, V10
   Wang J, 2015, FREE RADICAL BIO MED, V85, P95, DOI 10.1016/j.freeradbiomed.2015.04.005
   Wang K, 2021, TRANSPORTATION, V48, P773, DOI 10.1007/s11116-019-10056-0
   Wang TA, 2012, SCIENCE, V337, P839, DOI 10.1126/science.1222826
   Wang YY, 2017, JCI INSIGHT, V2, DOI 10.1172/jci.insight.87489
   Waxman Amalia, 2004, Food and Nutrition Bulletin, V25, P292
   Weber D, 2013, REDOX BIOL, V1, P226, DOI 10.1016/j.redox.2013.01.012
   West AC, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00462-2
   Wible RS, 2018, ELIFE, V7, DOI 10.7554/eLife.31656
   Wilkin TJ, 2004, J ROY SOC MED, V97, P511, DOI 10.1258/jrsm.97.11.511
   Wilms B, 2019, J CLIN ENDOCR METAB, V104, P1687, DOI 10.1210/jc.2018-01663
   Wongdee K, 2017, J PHYSIOL SCI, V67, P71, DOI 10.1007/s12576-016-0487-7
   Woodall BP, 2018, ACTA PHYSIOL, V223, DOI 10.1111/apha.13074
   Wu Q, 2019, J HEMATOL ONCOL, V12, DOI 10.1186/s13045-019-0778-6
   Xu JL, 2012, DIABETES, V61, P3208, DOI 10.2337/db11-1716
   Xu YQ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0044237
   Xue P, 2013, DIABETES, V62, P845, DOI 10.2337/db12-0584
   Yagishita Y, 2019, J ENDOCRINOL, V240, P403, DOI 10.1530/JOE-18-0355
   Yan LJ, 2018, ANIM MODEL EXP MED, V1, P7, DOI 10.1002/ame2.12001
   Yang SM, 2015, CLIN GENITOURIN CANC, V13, pE347, DOI 10.1016/j.clgc.2015.04.004
   Yesilbursa D, 2005, INT J OBESITY, V29, P142, DOI 10.1038/sj.ijo.0802794
   Yin JW, 2019, REDOX BIOL, V24, DOI 10.1016/j.redox.2019.101172
   Yu RG, 2019, DIABETES RES CLIN PR, V156, DOI 10.1016/j.diabres.2019.107831
   Yu Z, 2011, DIABETOLOGIA, V54, P922, DOI 10.1007/s00125-010-2001-8
   Zhang XM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0070663
   Zhang YKJ, 2012, TOXICOL APPL PHARM, V264, P305, DOI 10.1016/j.taap.2012.09.014
   Zipprich J, 2009, CANCER RES, V69, P2966, DOI 10.1158/0008-5472.CAN-08-3418
   Zitouni K, 2020, FREE RADICAL BIO MED, V161, P283, DOI 10.1016/j.freeradbiomed.2020.10.005
NR 239
TC 95
Z9 102
U1 3
U2 41
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD JUN
PY 2021
VL 42
AR 101887
DI 10.1016/j.redox.2021.101887
EA APR 2021
PG 17
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA RY2BK
UT WOS:000647722300010
PM 33579666
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU MacAulay, RK
   Halpin, A
   Cohen, AS
   Calamia, M
   Boeve, A
   Zhang, L
   Brouillette, RM
   Foil, HC
   Bruce-Keller, A
   Keller, JN
AF MacAulay, Rebecca K.
   Halpin, Amy
   Cohen, Alex S.
   Calamia, Matthew
   Boeve, Angelica
   Zhang, Le
   Brouillette, Robert M.
   Foil, Heather C.
   Bruce-Keller, Annadora
   Keller, Jeffrey N.
TI Predictors of Heterogeneity in Cognitive Function: APOE-e4, Sex,
   Education, Depression, and Vascular Risk
SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
LA English
DT Article
DE Cognitive decline; Modifiable risk factors; Cognitive reserve; Mild
   cognitive impairment; Alzheimer's disease
ID APOLIPOPROTEIN-E GENOTYPE; ALZHEIMER-DISEASE; METABOLIC SYNDROME;
   FOLLOW-UP; IMPAIRMENT; DEMENTIA; ASSOCIATION; SYMPTOMS; DECLINE; LIFE
AB Objective: Mild cognitive impairment and dementia are clinically heterogeneous disorders influenced by diverse risk factors. Improved characterization of the effect of multiple risk factors influence on specific cognitive functions may improve understanding of mechanisms in early cognitive change and lead to more effective interventions.
   Methods: Structural equation modeling (SEM) simultaneously examined the effects of modifiable (education, depression, and metabolic/vascular risk) and nonmodifiable risk factors (age, sex, and apolipoprotein E-epsilon 4 allele [APOE-e4] status) on specific cognitive domains in 461 cognitively normal older adults.
   Results: The hypothesized model(s) provided an adequate fit for the data. Sex differences in cognition, depression, and vascular risk were found. On average, men were higher in vascular risk with generally lower cognitive performance than women; women were more likely to have depression. APOE-e4 associated with depression but not age, sex, or metabolic/vascular risk. Depression associated with lower executive attention, memory, and language performance, whereas metabolic/vascular risk associated with lower executive attention, memory, and working memory. Older age and lower education are associated with worse performance across the cognitive domains. The combined risk factors accounted for 16%-47% of the variance in the cognitive domains.
   Conclusions: Results highlight the combined effect of risk factors on cognitive function. Future research is needed to determine whether the multifactorial risk effects on cognition vary by sex. Precision medicine approaches that integrate neuropsychological services may improve diagnostic accuracy and earlier identification of those at risk of cognitive decline.
C1 [MacAulay, Rebecca K.; Halpin, Amy; Boeve, Angelica] Univ Maine, Dept Psychol, 301 Little Hall, Orono, ME 04469 USA.
   [Cohen, Alex S.; Calamia, Matthew] Louisiana State Univ, Dept Psychol, Baton Rouge, LA 70803 USA.
   [Zhang, Le; Brouillette, Robert M.; Foil, Heather C.; Bruce-Keller, Annadora; Keller, Jeffrey N.] Inst Dementia Res & Prevent LSU, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
   [Zhang, Le] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Inst Aging,Dept Geriatr, Wuhan, Peoples R China.
C3 University of Maine System; University of Maine Orono; Louisiana State
   University System; Louisiana State University; Louisiana State
   University System; Louisiana State University; Pennington Biomedical
   Research Center; Huazhong University of Science & Technology
RP MacAulay, RK (corresponding author), Univ Maine, Dept Psychol, 301 Little Hall, Orono, ME 04469 USA.
EM Rebecca.macaulay@maine.edu
RI Calamia, Matthew/AFN-8305-2022
OI MacAulay, Rebecca/0000-0002-7985-998X; Calamia,
   Matthew/0000-0002-7252-7181
FU Hibernia National Bank/Edward G. Schlieder Chair
FX This work was supported by Hibernia National Bank/Edward G. Schlieder
   Chair and private community supporters. The funders had no role in the
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
CR Altmann A, 2014, ANN NEUROL, V75, P563, DOI 10.1002/ana.24135
   Anstey KJ, 2017, J ALZHEIMERS DIS, V56, P215, DOI 10.3233/JAD-160826
   Au B, 2017, AGEING RES REV, V35, P176, DOI 10.1016/j.arr.2016.09.005
   Bangen Katherine J, 2013, J Stroke Cerebrovasc Dis, V22, P1361, DOI 10.1016/j.jstrokecerebrovasdis.2013.03.013
   Barnes DE, 2011, LANCET NEUROL, V10, P819, DOI 10.1016/S1474-4422(11)70072-2
   Barnes LL, 2013, NEUROEPIDEMIOLOGY, V40, P211, DOI 10.1159/000342778
   Bernstein JPK, 2018, NEUROPSYCHOLOGY, V32, P220, DOI 10.1037/neu0000407
   Blair JR., 1989, Clinical Neuropsychologist, V3, P129, DOI [DOI 10.1080/13854048908403285, 10.1080/13854048908403285]
   Bondi MW, 2008, NEUROPSYCHOL REV, V18, P73, DOI 10.1007/s11065-008-9054-1
   Bondi MW, 2014, J INT NEUROPSYCH SOC, V20, P129, DOI 10.1017/S1355617714000010
   Byrne B, 2010, INTERNATIONAL HANDBOOK OF PSYCHOLOGY IN EDUCATION, P3
   Caselli RJ, 2009, NEW ENGL J MED, V361, P255, DOI 10.1056/NEJMoa0809437
   Chachamovich E, 2008, GERONTOLOGIST, V48, P593, DOI 10.1093/geront/48.5.593
   Edmonds EC, 2015, J ALZHEIMERS DIS, V47, P231, DOI 10.3233/JAD-150128
   Elias MF, 2000, ARCH NEUROL-CHICAGO, V57, P808, DOI 10.1001/archneur.57.6.808
   Eppig JS, 2017, J INT NEUROPSYCH SOC, V23, P564, DOI 10.1017/S135561771700039X
   Evans DA, 2003, ARCH NEUROL-CHICAGO, V60, P185, DOI 10.1001/archneur.60.2.185
   Farrer LA, 1997, JAMA-J AM MED ASSOC, V278, P1349, DOI 10.1001/jama.278.16.1349
   Feng L, 2013, J ALZHEIMERS DIS, V34, P649, DOI 10.3233/JAD-121885
   Ferretti MT, 2018, NAT REV NEUROL, V14, P457, DOI 10.1038/s41582-018-0032-9
   FOLSTEIN MF, 1975, J PSYCHIAT RES, V12, P189, DOI 10.1016/0022-3956(75)90026-6
   Geda YE, 2006, ARCH NEUROL-CHICAGO, V63, P435, DOI 10.1001/archneur.63.3.435
   Gorelick PB, 2011, STROKE, V42, P2672, DOI 10.1161/STR.0b013e3182299496
   Grabovich A, 2010, AM J GERIAT PSYCHIAT, V18, P227, DOI 10.1097/JGP.0b013e3181cb87d6
   Hamer M, 2018, J EPIDEMIOL COMMUN H, V72, P477, DOI 10.1136/jech-2017-210228
   Hayden KM, 2011, ALZ DIS ASSOC DIS, V25, P128, DOI 10.1097/WAD.0b013e3181ffa76d
   Ho J. K., 2018, J INT NEUROPSYCH SOC, P1
   Hohman TJ, 2018, JAMA NEUROL, V75, P989, DOI 10.1001/jamaneurol.2018.0821
   Howieson DB, 2008, J INT NEUROPSYCH SOC, V14, P192, DOI 10.1017/S1355617708080375
   Ismail Z, 2017, JAMA PSYCHIAT, V74, P58, DOI 10.1001/jamapsychiatry.2016.3162
   Jack CR, 2015, JAMA NEUROL, V72, P511, DOI 10.1001/jamaneurol.2014.4821
   Johnson JK, 2012, BRAIN IMAGING BEHAV, V6, P540, DOI 10.1007/s11682-012-9161-8
   Karlsson IK, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/tp.2017.110
   Kline RB, 2011, Principles and practice of structural equation modelling
   Livingston Gill, 2017, Lancet, V390, P2673, DOI 10.1016/S0140-6736(17)31363-6
   Lopez OL, 2003, ARCH NEUROL-CHICAGO, V60, P1394, DOI 10.1001/archneur.60.10.1394
   Luciano M, 2015, PSYCHOSOM MED, V77, P480, DOI 10.1097/PSY.0000000000000190
   MacAulay RK, 2018, J CLIN EXP NEUROPSYC, V40, P292, DOI 10.1080/13803395.2017.1342772
   MacAulay RK, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0099436
   MacCallum RC, 1996, PSYCHOL METHODS, V1, P130, DOI 10.1037/1082-989X.1.2.130
   Mackin RS, 2014, AM J GERIAT PSYCHIAT, V22, P1633, DOI 10.1016/j.jagp.2014.02.006
   MORRIS JC, 1993, NEUROLOGY, V43, P2412, DOI 10.1212/WNL.43.11.2412-a
   Morris JC, 2006, ALZ DIS ASSOC DIS, V20, P210, DOI 10.1097/01.wad.0000213865.09806.92
   Mufson Elliott J., 2000, Journal of Comparative Neurology, V427, P19, DOI 10.1002/1096-9861(20001106)427:1<19::AID-CNE2>3.0.CO;2-A
   Musliner KL, 2016, J AFFECT DISORDERS, V192, P199, DOI 10.1016/j.jad.2015.12.030
   Nebel RA, 2018, ALZHEIMERS DEMENT, V14, P1171, DOI 10.1016/j.jalz.2018.04.008
   Ng TP, 2016, JAMA NEUROL, V73, P456, DOI 10.1001/jamaneurol.2015.4899
   Niti M, 2009, J GERONTOL A-BIOL, V64, P306, DOI 10.1093/gerona/gln013
   Pink A, 2015, NEUROLOGY, V84, P935, DOI 10.1212/WNL.0000000000001307
   Prince M., 2015, World Alzheimer Report 2015-The Global Impact of Dementia: An analysis of prevalence, incidence, cost and trends2015
   Raz N., 2000, The Handbook of Aging and Cognition
   Reas ET, 2019, NEUROPSYCHOLOGY, V33, P406, DOI 10.1037/neu0000501
   Reitz C, 2009, NEUROSCIENCE, V164, P174, DOI 10.1016/j.neuroscience.2009.04.006
   Ritchie Karen, 2004, Dialogues Clin Neurosci, V6, P401
   Schneider JA, 2007, NEUROLOGY, V69, P2197, DOI 10.1212/01.wnl.0000271090.28148.24
   SHEIKH J I, 1986, Clinical Gerontologist, V5, P165
   Small BJ, 2004, PSYCHOL AGING, V19, P592, DOI 10.1037/0882-7974.19.4.592
   Snowden MB, 2015, AM J GERIAT PSYCHIAT, V23, P897, DOI 10.1016/j.jagp.2014.09.002
   Sperling RA, 2011, ALZHEIMERS DEMENT, V7, P280, DOI 10.1016/j.jalz.2011.03.003
   Stern Y, 2002, J INT NEUROPSYCH SOC, V8, P448, DOI 10.1017/S1355617702813248
   Sundermann EE, 2019, NEUROLOGY, V93, pE1881, DOI 10.1212/WNL.0000000000008467
   Tervo S, 2004, DEMENT GERIATR COGN, V17, P196, DOI 10.1159/000076356
   Viticchi G, 2014, J ALZHEIMERS DIS, V41, P401, DOI 10.3233/JAD-132480
   Weintraub S, 2009, ALZ DIS ASSOC DIS, V23, P91, DOI 10.1097/WAD.0b013e318191c7dd
   Welsh-Bohmer KA, 2009, CLIN NEUROPSYCHOL, V23, P77, DOI 10.1080/13854040801894730
   Zahodne LB, 2011, J INT NEUROPSYCH SOC, V17, P1039, DOI 10.1017/S1355617711001044
NR 66
TC 15
Z9 15
U1 0
U2 17
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0887-6177
EI 1873-5843
J9 ARCH CLIN NEUROPSYCH
JI Arch. Clin. Neuropsychol.
PD SEP
PY 2020
VL 35
IS 6
BP 660
EP 670
DI 10.1093/arclin/acaa014
PG 11
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA OW5NS
UT WOS:000592933700002
PM 32129455
OA Bronze
DA 2025-06-11
ER

PT J
AU Fichna, M
   Krzysko-Pieczka, I
   Zurawek, M
   Skowronska, B
   Januszkiewicz-Lewandowska, D
   Fichna, P
AF Fichna, Marta
   Krzysko-Pieczka, Izabela
   Zurawek, Magdalena
   Skowronska, Bogda
   Januszkiewicz-Lewandowska, Danuta
   Fichna, Piotr
TI &ITFKBP5&IT polymorphism is associated with insulin resistance in
   children and adolescents with obesity
SO OBESITY RESEARCH & CLINICAL PRACTICE
LA English
DT Article
DE Childhood obesity; FKBP5 gene; Polymorphism; Insulin resistance;
   Metabolic syndrome
ID BODY-MASS INDEX; ORAL GLUCOSE-TOLERANCE; SENSITIVITY INDEXES; METABOLIC
   SYNDROME; GLUCOCORTICOID-RECEPTOR; MAJOR DEPRESSION; PUBERTAL CHANGES;
   MESSENGER-RNA; FKBP5; CORTISOL
AB Objective: Since metabolic syndrome shares several clinical features with hypercortisolism, it was hypothesised that genes altering individual glucocorticoid (GC) sensitivity might be implicated in pathogenesis of obesity and its adverse outcomes. FKBP5 gene encodes a chaperon protein in the GC receptor (GR) complex, which modulates steroid action upon target genes. Its functional variant, rs1360780, may enhance FKBP5 gene transcription, affect GR signalling and thereby influence the hypothalamo-pituitary-adrenal axis. We investigated the association of rs1360780 with obesity and metabolic characteristics in 250 obese children and adolescents (mean age 12.3 +/- 3.6 years, BMI >= 95th percentile).& para;& para;Methods: Anthropometric measurements, body composition, biochemical and hormonal results were analysed. Genotyping of rs1360780 was compared with 568 lean controls.& para;& para;Results: Impaired fasting glucose was present in 8.8%, glucose intolerance in 10.4%, diabetes in 2.8% and dyslipidemia in 28.8% obese individuals. Hypertension was diagnosed in 34 out of 143 patients. No difference was found in FKBP5 polymorphism distribution between subjects with obesity and controls (p > 0.05). Stratification by rs1360780 revealed no differences in body mass and composition. However, carriers of the minor allele displayed enhanced insulin resistance (p = 0.009) and elevated serum triglyceride (p = 0.006), whereas cholesterol, HbA1c, and oral glucose challenge results were similar for all genotypes. Morning ACTH and cortisol did not differ but evening cortisol was higher in minor allele carriers (p=0.039), although this association was lost in logistic regression analysis.& para;& para;Conclusion: This study does not support the association of FKBP5 with obesity but demonstrates plausible implication of its variant in susceptibility to obesity-related insulin resistance and hypertriglyceridemia. (C) 2016 Published by Elsevier Ltd on behalf of Asia Oceania Association for the Study of Obesity.
C1 [Fichna, Marta] Poznan Univ Med Sci, Dept Endocrinol Metab & Internal Med, 49 Przybyszewskiego, PL-60355 Poznan, Poland.
   [Fichna, Marta; Zurawek, Magdalena; Januszkiewicz-Lewandowska, Danuta] Polish Acad Sci, Inst Human Genet, 32 Strzeszynska, PL-60479 Poznan, Poland.
   [Krzysko-Pieczka, Izabela; Skowronska, Bogda; Fichna, Piotr] Poznan Univ Med Sci, Dept Paediat Diabet & Obes, 27-33 Szpitalna, PL-60572 Poznan, Poland.
   [Januszkiewicz-Lewandowska, Danuta] Poznan Univ Med Sci, Dept Oncol Hematol & Bone Marrow Transplantat, 27-33 Szpitalna, PL-60572 Poznan, Poland.
C3 Poznan University of Medical Sciences; Polish Academy of Sciences;
   Institute of Human Genetics of the Polish Academy of Sciences; Poznan
   University of Medical Sciences; Poznan University of Medical Sciences
RP Fichna, M (corresponding author), Poznan Univ Med Sci, Dept Endocrinol Metab & Internal Med, 49 Przybyszewskiego, PL-60355 Poznan, Poland.
EM mfichna@man.poznan.pl
RI Januszkiewicz-Lewandowska, Danuta/AAE-2542-2020
OI Zurawek, Magdalena/0000-0002-0345-4054; Fichna,
   Marta/0000-0003-2865-7074; Skowronska, Bogda/0000-0002-5598-4858
FU Polish Diabetes Association
FX The study was supported by a research grant from the Polish Diabetes
   Association (awarded to M.F., 2013). We are grateful to the authorities
   and employees of the Regional Blood Transfusion Centre in Poznan for
   their invaluable help with control sample collection.
CR [Anonymous], INT J NEUROPSYCHOPHA
   Balsevich G, 2014, J ENDOCRINOL, V222, P15, DOI 10.1530/JOE-14-0129
   Binder EB, 2004, NAT GENET, V36, P1319, DOI 10.1038/ng1479
   Binder EB, 2008, JAMA-J AM MED ASSOC, V299, P1291, DOI 10.1001/jama.299.11.1291
   COLE TJ, 1995, ARCH DIS CHILD, V73, P25, DOI 10.1136/adc.73.1.25
   Constantinopoulos P, 2015, EUR J ENDOCRINOL, V172, DOI 10.1530/EJE-14-0626
   Di Blasio AM, 2003, CLIN ENDOCRINOL, V59, P68, DOI 10.1046/j.1365-2265.2003.01798.x
   Fani N, 2013, JAMA PSYCHIAT, V70, P392, DOI 10.1001/2013.jamapsychiatry.210
   Friedman TC, 1996, ENDOCR J, V43, P645, DOI 10.1507/endocrj.43.645
   GREGOIRE F, 1991, EXP CELL RES, V196, P270, DOI 10.1016/0014-4827(91)90261-R
   Han JC, 2010, LANCET, V375, P1737, DOI 10.1016/S0140-6736(10)60171-7
   Ising M, 2008, EUR J NEUROSCI, V28, P389, DOI 10.1111/j.1460-9568.2008.06332.x
   Klengel T, 2013, NAT NEUROSCI, V16, P33, DOI 10.1038/nn.3275
   Kulaga Z, 2011, EUR J PEDIATR, V170, P599, DOI 10.1007/s00431-010-1329-x
   Li L, 2015, OBESITY, V23, P1625, DOI 10.1002/oby.21143
   MARSHALL WA, 1969, ARCH DIS CHILD, V44, P291, DOI 10.1136/adc.44.235.291
   MARSHALL WA, 1970, ARCH DIS CHILD, V45, P13, DOI 10.1136/adc.45.239.13
   Marzuillo P, 2016, PEDIAT DIABETES
   Massa F, 2010, J NEUROSCI, V30, P6273, DOI 10.1523/JNEUROSCI.2648-09.2010
   Masuccio FG, 2009, J PEDIATR ENDOCR MET, V22, P695
   Matsuda M, 1999, DIABETES CARE, V22, P1462, DOI 10.2337/diacare.22.9.1462
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Menke A, 2013, GENES BRAIN BEHAV, V12, P289, DOI 10.1111/gbb.12026
   Papanicolaou DA, 1998, J CLIN ENDOCR METAB, V83, P1163, DOI 10.1210/jc.83.4.1163
   Pasquali R, 2006, ANN NY ACAD SCI, V1083, P111, DOI 10.1196/annals.1367.009
   Phillips DIW, 1998, J CLIN ENDOCR METAB, V83, P757, DOI 10.1210/jc.83.3.757
   PHILLIPS DIW, 1994, DIABETIC MED, V11, P286, DOI 10.1111/j.1464-5491.1994.tb00273.x
   Prodam F, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-44
   Radikova Z, 2006, EXP CLIN ENDOCR DIAB, V114, P249, DOI 10.1055/s-2006-924233
   Reinehr T, 2005, METABOLISM, V54, P397, DOI 10.1016/j.metabol.2004.10.008
   Reinehr T, 2004, HORM RES, V62, P107, DOI 10.1159/000079841
   Reynolds PD, 1999, J CLIN ENDOCR METAB, V84, P663, DOI 10.1210/jc.84.2.663
   RIZZA RA, 1982, J CLIN ENDOCR METAB, V54, P131, DOI 10.1210/jcem-54-1-131
   Saiegh L, 2016, OBES RES CLIN PRACT, V10, P275, DOI 10.1016/j.orcp.2015.07.004
   Schorr M, 2015, J CLIN ENDOCR METAB, V100, P3313, DOI 10.1210/JC.2015-2078
   SLAVIN BG, 1994, J LIPID RES, V35, P1535
   Speakman JR, 2013, HUM HERED, V75, P57, DOI 10.1159/000353585
   Stechschulte LA, 2014, MOL ENDOCRINOL, V28, P1265, DOI 10.1210/me.2014-1022
   Szczepankiewicz A, 2014, J AFFECT DISORDERS, V164, P33, DOI 10.1016/j.jad.2014.04.002
   Utzschneider KM, 2009, DIABETES CARE, V32, P335, DOI 10.2337/dc08-1478
   Vermeer H, 2004, MOL CELL ENDOCRINOL, V218, P49, DOI 10.1016/j.mce.2003.12.011
   WABITSCH M, 1995, J CLIN ENDOCR METAB, V80, P3469, DOI 10.1210/jc.80.12.3469
   Weiss R, 2015, DIABETES CARE, V38, P689, DOI 10.2337/dc14-2183
   Wochnik GM, 2005, J BIOL CHEM, V280, P4609, DOI 10.1074/jbc.M407498200
   Yang L, 2012, AM J PHYSIOL-ENDOC M, V302, pE987, DOI 10.1152/ajpendo.00474.2011
   Zeitler P, 2014, PEDIATR DIABETES, V15, P26, DOI 10.1111/pedi.12179
   Zimmet P, 2007, PEDIATR DIABETES, V8, P299, DOI 10.1111/j.1399-5448.2007.00271.x
NR 47
TC 16
Z9 16
U1 0
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-403X
EI 1878-0318
J9 OBES RES CLIN PRACT
JI Obes. Res. Clin. Pract.
PD JAN-FEB
PY 2018
VL 12
IS 1
SU 1
BP 62
EP 70
DI 10.1016/j.orcp.2016.11.007
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA GB6KC
UT WOS:000429177000007
PM 28007534
DA 2025-06-11
ER

PT J
AU Feng, L
   Chong, MS
   Lim, WS
   Lee, TS
   Collinson, SL
   Yap, P
   Ng, TP
AF Feng, Liang
   Chong, Mei Sian
   Lim, Wee Shiong
   Lee, Tih Shih
   Collinson, Simon L.
   Yap, Philip
   Tze Pin Ng
TI Metabolic Syndrome and Amnestic Mild Cognitive Impairment: Singapore
   Longitudinal Ageing Study-2 Findings
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Amnestic mild cognitive impairment; APOE-epsilon 4; cognition; metabolic
   syndrome
ID CHINESE OLDER-ADULTS; BODY-MASS INDEX; RISK-FACTORS; APOLIPOPROTEIN-E;
   ALZHEIMERS-DISEASE; VASCULAR DEMENTIA; INSULIN-RESISTANCE; FOLLOW-UP;
   DECLINE; OBESITY
AB Metabolic syndrome (MetS) is reported to be associated with cognitive decline and dementia, in particular vascular dementia. However, the evidence linking MetS to Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI), a precursor of AD, is inconsistent and limited. This study examined the association of MetS and its components with aMCI and how APOE-epsilon e4 and younger age influenced this association. Participants with aMCI (n = 98) and cognitively normal controls (n = 802) were identified from baseline data in a second wave cohort of older subjects aged 55 and over in the Singapore Longitudinal Ageing Study-2 (SLAS-2) in 2009/2010. The associations of MetS and its individual components with aMCI were analyzed using logistic regression controlling for age, gender, education, current smoking, alcohol drink, leisure time activities score, Geriatric Depression Scale score, APOE-epsilon 4, and heart disease or stroke. The analysis was repeated for associations stratified by age and APOE-epsilon 4 status. In multivariate analysis, MetS was associated with an elevated risk of aMCI (OR = 1.79; 95% CI 1.15-2.77). Among MetS components, central obesity showed a significant association with aMCI (OR = 1.77; 95% CI 1.11-2.82). The association between MetS and aMCI remained significant on repeated analysis among subjects free of heart disease and stroke. This association was particularly stronger among participants with APOE-epsilon 4 allele (OR = 3.35; 95% CI, 1.03-10.85) and younger (< 65 years) participants with APOE-epsilon 4 (OR = 6.57; 95% CI, 1.03-41.74). MetS was found to be associated with aMCI, especially in individuals with APOE-epsilon 4 at younger age in this middle-aged and older cohort.
C1 [Feng, Liang; Chong, Mei Sian; Lim, Wee Shiong; Lee, Tih Shih; Yap, Philip; Tze Pin Ng] Natl Univ Singapore, Yong Loo Lin Sch Med, Gerontol Res Programme, Singapore 119228, Singapore.
   [Feng, Liang; Tze Pin Ng] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Singapore 119228, Singapore.
   [Chong, Mei Sian; Lim, Wee Shiong] Tan Tock Seng Hosp, Dept Geriatr Med, Singapore, Singapore.
   [Lee, Tih Shih] Duke NUS Grad Med Sch, Neurosci Program, Singapore, Singapore.
   [Collinson, Simon L.] Natl Univ Singapore, Dept Psychol, Singapore 119228, Singapore.
   [Yap, Philip] Alexandra Hosp, Dept Geriatr Med, Singapore, Singapore.
C3 National University of Singapore; National University of Singapore; Tan
   Tock Seng Hospital; National University of Singapore; National
   University of Singapore
RP Ng, TP (corresponding author), Natl Univ Singapore, Natl Univ Hosp, Dept Psychol Med, Gerontol Res Programme, NUHS Tower Block,9th Floor,1E Kent Ridge Rd, Singapore 119228, Singapore.
EM pcmngtp@nus.edu.sg
RI Collinson, Simon/HHZ-6965-2022; Chong, Mei Sian/A-4978-2013
OI Lim, Wee Shiong/0000-0003-3975-7230; Collinson, Simon
   Lowes/0000-0001-9232-9732; Chong, Mei Sian/0000-0001-9324-5901
FU Biomedical Research Council, Agency for Science, Technology and Research
   (A*STAR) [03/1/21/17/214]; Geylang East Home for the Aged; Presbyterian
   Community Services; Thye Hua Kwan Moral Society (Moral Neighbourhood
   Links); Yuhua Neighbourhood Link; Henderson Senior Citizens' Home; NTUC
   Eldercare Co-op Ltd; Thong Kheng Seniors Activity Centre (Queenstown
   Centre); Redhill Moral Seniors Activity Centre
FX The study is supported by a research grant (No. 03/1/21/17/214) from the
   Biomedical Research Council, Agency for Science, Technology and Research
   (A*STAR). We thank the following voluntary welfare organizations for
   their support of the Singapore Longitudinal Ageing Studies: Geylang East
   Home for the Aged, Presbyterian Community Services, Thye Hua Kwan Moral
   Society (Moral Neighbourhood Links), Yuhua Neighbourhood Link, Henderson
   Senior Citizens' Home, NTUC Eldercare Co-op Ltd, Thong Kheng Seniors
   Activity Centre (Queenstown Centre) and Redhill Moral Seniors Activity
   Centre.
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   [Anonymous], 1996, Color Trails Test
   [Anonymous], 1981, ADULT INTELLIGENCE S
   Benedict H.R.B., 1997, Brief visuospatial memory test-revised professional manual
   Blair CK, 2005, NEUROLOGY, V64, P268, DOI 10.1212/01.WNL.0000149643.91367.8A
   Bonora E, 1998, DIABETES, V47, P1643, DOI 10.2337/diabetes.47.10.1643
   Bookheimer S, 2009, ANNU REV CLIN PSYCHO, V5, P343, DOI 10.1146/annurev.clinpsy.032408.153625
   Broekman BFP, 2008, J AFFECT DISORDERS, V108, P285, DOI 10.1016/j.jad.2007.10.005
   Buchman AS, 2005, NEUROLOGY, V65, P892, DOI 10.1212/01.wnl.0000176061.33817.90
   Carmelli D, 1998, NEUROLOGY, V50, P1580, DOI 10.1212/WNL.50.6.1580
   Cheung RW, 2004, J INT NEUROPSYCH SOC, V10, P46, DOI 10.1017/S1355617704101069
   Craft S, 2006, ALZHEIMERS DIS RELAT, P111
   Craft S, 2009, ARCH NEUROL-CHICAGO, V66, P300, DOI 10.1001/archneurol.2009.27
   Davignon J, 2005, ARTERIOSCL THROM VAS, V25, P267, DOI 10.1161/01.ATV.0000154570.50696.2c
   Dik MG, 2007, DIABETES CARE, V30, P2655, DOI 10.2337/dc06-1190
   Farias ST, 2009, ARCH NEUROL-CHICAGO, V66, P1151, DOI 10.1001/archneurol.2009.106
   Feng L, 2012, SINGAP MED J, V53, P458
   Fewlass DC, 2004, FASEB J, V18, P1870, DOI 10.1096/fj.04-2572com
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Forti P, 2010, J AM GERIATR SOC, V58, P487, DOI 10.1111/j.1532-5415.2010.02731.x
   Frisardi V, 2010, J ALZHEIMERS DIS, V21, P57, DOI 10.3233/JAD-2010-100015
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Grossman H, 2003, CNS SPECTRUMS, V8, P815, DOI 10.1017/S1092852900019258
   Gustafson D, 2003, ARCH INTERN MED, V163, P1524, DOI 10.1001/archinte.163.13.1524
   Haan MN, 1999, JAMA-J AM MED ASSOC, V282, P40, DOI 10.1001/jama.282.1.40
   Harvey J, 2003, MOL NEUROBIOL, V28, P245, DOI 10.1385/MN:28:3:245
   Hassenstab JJ, 2010, DEMENT GERIATR COGN, V29, P356, DOI 10.1159/000296071
   Ho RCM, 2008, AM J GERIAT PSYCHIAT, V16, P519, DOI 10.1097/JGP.0b013e31816b7841
   HUGHES CP, 1982, BRIT J PSYCHIAT, V140, P566, DOI 10.1192/bjp.140.6.566
   Kalmijn S, 2000, ARTERIOSCL THROM VAS, V20, P2255, DOI 10.1161/01.ATV.20.10.2255
   Kivipelto M, 2002, ANN INTERN MED, V137, P149, DOI 10.7326/0003-4819-137-3-200208060-00006
   Kivipelto M, 2005, ARCH NEUROL-CHICAGO, V62, P1556, DOI 10.1001/archneur.62.10.1556
   Laudisio A, 2008, CLIN NUTR, V27, P747, DOI 10.1016/j.clnu.2008.07.001
   Lee CKY, 2012, CLIN NEUROPSYCHOL, V26, P321, DOI 10.1080/13854046.2011.652180
   Lezak MD, 1995, NEUROPSYCHOLOGICAL A
   Li XL, 2002, NEUROSCIENCE, V113, P607, DOI 10.1016/S0306-4522(02)00162-8
   Lim WS, 2012, JARCP, V1, P109
   Luchsinger JA, 2009, J ALZHEIMERS DIS, V16, P693, DOI 10.3233/JAD-2009-1022
   MAHONEY F I, 1965, Md State Med J, V14, P61
   Martins IJ, 2006, MOL PSYCHIATR, V11, P721, DOI 10.1038/sj.mp.4001854
   Modrego Pedro J., 2006, Current Alzheimer Research, V3, P161, DOI 10.2174/156720506776383103
   Muller M, 2007, DEMENT GERIATR COGN, V24, P185, DOI 10.1159/000105927
   Myers RH, 1996, NEUROLOGY, V46, P673, DOI 10.1212/WNL.46.3.673
   Nasreddine ZS, 2005, J AM GERIATR SOC, V53, P695, DOI 10.1111/j.1532-5415.2005.53221.x
   Nesto Richard W, 2003, Rev Cardiovasc Med, V4 Suppl 6, pS11
   Nieto-Vazquez Iria, 2008, Archives of Physiology and Biochemistry, V114, P183, DOI 10.1080/13813450802181047 
   Niti M, 2008, INT PSYCHOGERIATR, V20, P237, DOI 10.1017/S1041610207006655
   Nourhashémi F, 2003, NEUROLOGY, V60, P117, DOI 10.1212/01.WNL.0000038910.46217.AA
   Nyunt MSZ, 2009, AGING MENT HEALTH, V13, P376, DOI 10.1080/13607860902861027
   O'Bryant SE, 2008, ARCH NEUROL-CHICAGO, V65, P1091, DOI 10.1001/archneur.65.8.1091
   Peila R, 2002, DIABETES, V51, P1256, DOI 10.2337/diabetes.51.4.1256
   Petersen RC, 1999, ARCH NEUROL-CHICAGO, V56, P303, DOI 10.1001/archneur.56.3.303
   Portet F, 2006, J NEUROL NEUROSUR PS, V77, P714, DOI 10.1136/jnnp.2005.085332
   Raffaitin C, 2009, DIABETES CARE, V32, P169, DOI 10.2337/dc08-0272
   Razay G, 2007, ARCH NEUROL-CHICAGO, V64, P93, DOI 10.1001/archneur.64.1.93
   Roberts RO, 2010, ALZ DIS ASSOC DIS, V24, P11, DOI 10.1097/WAD.0b013e3181a4485c
   Solfrizzi V, 2011, NEUROBIOL AGING, V32, P1932, DOI 10.1016/j.neurobiolaging.2009.12.012
   Solfrizzi V, 2010, J NEUROL NEUROSUR PS, V81, P433, DOI 10.1136/jnnp.2009.181743
   van den Berg E, 2007, NEUROLOGY, V69, P979, DOI 10.1212/01.wnl.0000271381.30143.75
   VANDUIJN CM, 1994, NAT GENET, V7, P74, DOI 10.1038/ng0594-74
   Vanhanen M, 2006, NEUROLOGY, V67, P843, DOI 10.1212/01.wnl.0000234037.91185.99
   Wang J, 2008, STROKE, V39, P1078, DOI 10.1161/STROKEAHA.107.499830
   Wechsler D, 1997, WAIS-III: Administration and Scoring Manual: Wechsler Adult Intelligence Scale, V3
   White H, 1996, J AM GERIATR SOC, V44, P265, DOI 10.1111/j.1532-5415.1996.tb00912.x
   Whitmer RA, 2008, NEUROLOGY, V71, P1057, DOI 10.1212/01.wnl.0000306313.89165.ef
   Yaffe K, 2004, JAMA-J AM MED ASSOC, V292, P2237, DOI 10.1001/jama.292.18.2237
   Yaffe K, 2007, J AM GERIATR SOC, V55, P758, DOI 10.1111/j.1532-5415.2007.01139.x
   Yaffe K, 2009, ARCH NEUROL-CHICAGO, V66, P324, DOI 10.1001/archneurol.2008.566
   YESAVAGE JA, 1988, PSYCHOPHARMACOL BULL, V24, P709
NR 69
TC 50
Z9 54
U1 1
U2 12
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2013
VL 34
IS 3
BP 649
EP 657
DI 10.3233/JAD-121885
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA 104KK
UT WOS:000315991500008
PM 23246920
DA 2025-06-11
ER

PT J
AU Teasdale, S
   Mörkl, S
   Müller-Stierlin, AS
AF Teasdale, Scott
   Moerkl, Sabrina
   Mueller-Stierlin, Annabel Sandra
TI Nutritional psychiatry in the treatment of psychotic disorders: Current
   hypotheses and research challenges
SO BRAIN BEHAVIOR & IMMUNITY-HEALTH
LA English
DT Article
DE Nutritional psychiatry; Diet; Mental health; Gut -brain axis; Research
   challenges; Psychosis
ID SEVERE MENTAL-ILLNESS; GUT MICROBIOTA; VITAMIN-D; METABOLIC SYNDROME;
   BIPOLAR DISORDER; FOLATE LEVELS; SCHIZOPHRENIA; METAANALYSIS;
   INFLAMMATION; DIET
AB Current treatment for schizophrenia-spectrum disorders focusses primarily on psychotropic medication to treat symptoms, though their efficacy varies between patients and psychotropic medication is often accompanied by severe side effects. Nutritional interventions to prevent and treat mental illness have received considerable attention over recent years. However, evidence for nutritional interventions in schizophrenia-spectrum disorders remains limited in quantity and quality. Pathways currently in focus include: i) nutritional deficits and impairments in glucose metabolism, ii) inflammation and immune dysregulation (also known from the mild encephalitis hypothesis), and iii) altered gut microbiota. All of which appear to be interconnected. Key limiting factors for advancing research in this field are research challenges associated with assessing and interpreting inflammatory profiles, microbiota and subjective nutritional assessments, which is further complicated by illness characteristics. This review describes the state of evidence for key hypotheses, including underlying mechanisms, implicated in schizophrenia-spectrum disorders, the challenges in nutritional psychiatry research and the current state of nutrition interventions in mental healthcare.
C1 [Teasdale, Scott] Univ New South Wales Sydney, Sch Psychiat, Sydney, Australia.
   [Moerkl, Sabrina] Med Univ Graz, Univ Klinik Psychiat & Psychotherapeut Med, Graz, Austria.
   [Mueller-Stierlin, Annabel Sandra] Univ Klinikum Ulm, Klin Psychiat & Psychotherapie 2, Ulm, Germany.
C3 University of New South Wales Sydney; Medical University of Graz; Ulm
   University
RP Müller-Stierlin, AS (corresponding author), Univ Ulm, Dept Psychiat 2, Ludwig Heilmeyer Str 2, D-89312 Gunzburg, Germany.
EM scott.teasdale@unswalumni.com; sabrina.moerkl@medunigraz.at;
   annabel.mueller-stierlin@uni-ulm.de
RI Teasdale, Scott/AFP-0676-2022; Mueller-Stierlin, Annabel/AAC-1241-2022
OI Mueller-Stierlin, Annabel Sandra/0000-0003-2812-5115; Teasdale,
   Scott/0000-0001-6769-8421
CR Akhondzadeh S, 2007, SCHIZOPHR RES, V90, P179, DOI 10.1016/j.schres.2006.11.016
   Allott K, 2019, BIOL PSYCHIAT, V86, P35, DOI 10.1016/j.biopsych.2018.12.018
   Andrew AS, 2017, INT J MOL SCI, V18, DOI [10.3390/ijms18030535, 10.3390/ijms18030651]
   Arroll MA, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-91
   Babulas V, 2006, AM J PSYCHIAT, V163, P927, DOI 10.1176/appi.ajp.163.5.927
   Bechter K, 2013, PROG NEURO-PSYCHOPH, V42, P71, DOI 10.1016/j.pnpbp.2012.06.019
   Belbasis L, 2018, ACTA PSYCHIAT SCAND, V137, P88, DOI 10.1111/acps.12847
   Bostock ECS, 2017, FRONT PSYCHIATRY, V8, DOI 10.3389/fpsyt.2017.00043
   Braniste V, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3009759
   Briguglio M, 2018, NUTRIENTS, V10, DOI 10.3390/nu10050591
   Brown AS, 2010, AM J PSYCHIAT, V167, P261, DOI 10.1176/appi.ajp.2009.09030361
   Calder PC, 2013, BRIT J NUTR, V109, pS1, DOI 10.1017/S0007114512005119
   Calder PC, 2009, BRIT J NUTR, V101, P1, DOI 10.1017/S0007114508076228
   Cao B, 2016, PSYCHIAT RES, V245, P1, DOI 10.1016/j.psychres.2016.03.003
   Cao B, 2016, SCHIZOPHR RES, V172, P216, DOI 10.1016/j.schres.2016.01.050
   Chen TT, 2017, FOOD FUNCT, V8, P1166, DOI [10.1039/c6fo01532h, 10.1039/C6FO01532H]
   Chiang M, 2016, EVID-BASED MENT HEAL, V19, P6, DOI 10.1136/eb-2015-102117
   Chiveri L, 2003, EUR NEUROL, V50, P182, DOI 10.1159/000073062
   Curtis J, 2018, AUST NZ J PSYCHIAT, V52, P602, DOI 10.1177/0004867417753553
   Curtis J, 2016, EARLY INTERV PSYCHIA, V10, P267, DOI 10.1111/eip.12230
   Dash S, 2015, CURR OPIN PSYCHIATR, V28, P1, DOI 10.1097/YCO.0000000000000117
   Dinan TG, 2014, MOL PSYCHIATR, V19, P1252, DOI 10.1038/mp.2014.93
   Dinan TG, 2020, WORLD PSYCHIATRY, V19, P111, DOI 10.1002/wps.20726
   Early Psychosis Guidelines Writing Group and EPPIC National Support Program, 2016, Australian Clinical Guidelines for Early Psychosis [Internet]
   Eisenstein M, 2020, NATURE, V577, pS6, DOI 10.1038/d41586-020-00193-3
   Eyles DW, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-35418-z
   Fagundes CP, 2013, BRAIN BEHAV IMMUN, V27, P8, DOI 10.1016/j.bbi.2012.06.014
   Fan Xiaoduo, 2007, Expert Rev Neurother, V7, P789, DOI 10.1586/14737175.7.7.789
   Firth J, 2017, PSYCHOL MED, V47, P1515, DOI 10.1017/S0033291717000022
   Firth J, 2015, PSYCHOL MED, V45, P1343, DOI 10.1017/S0033291714003110
   Firth J, 2019, WORLD PSYCHIATRY, V18, P308, DOI 10.1002/wps.20672
   Firth J, 2019, LANCET PSYCHIAT, V6, P675, DOI 10.1016/S2215-0366(19)30132-4
   Firth J, 2019, PSYCHOSOM MED, V81, P265, DOI 10.1097/PSY.0000000000000673
   Firth J, 2018, WORLD PSYCHIATRY, V17, P365, DOI 10.1002/wps.20571
   Firth J, 2018, SCHIZOPHRENIA BULL, V44, P1275, DOI 10.1093/schbul/sbx162
   Firth J, 2017, SCHIZOPHRENIA BULL, V43, P546, DOI 10.1093/schbul/sbw115
   Flatow J, 2013, BIOL PSYCHIAT, V74, P400, DOI 10.1016/j.biopsych.2013.03.018
   Garcia-Rizo C, 2012, PSYCHIAT RES, V198, P212, DOI 10.1016/j.psychres.2011.08.014
   Garcion E, 2002, TRENDS ENDOCRIN MET, V13, P100, DOI 10.1016/S1043-2760(01)00547-1
   Glassman Matthew, 2018, J Neuropsychiatry (Foster City), V2, DOI 10.21767/2471-8548.10008
   GOLD JM, 1993, PSYCHIAT CLIN N AM, V16, P295
   Green MF, 2000, SCHIZOPHRENIA BULL, V26, P119, DOI 10.1093/oxfordjournals.schbul.a033430
   Guu TW, 2019, PSYCHOTHER PSYCHOSOM, V88, P263, DOI [10.1159/000502652, 10.1159/000504232]
   Hafizi S, 2018, SCHIZOPHRENIA BULL, V44, pS390, DOI 10.1093/schbul/sby018.956
   He Y, 2018, EUR PSYCHIAT, V53, P37, DOI 10.1016/j.eurpsy.2018.05.011
   Hébert JR, 2019, ADV NUTR, V10, P185, DOI 10.1093/advances/nmy071
   Hiroshi Hashimoto, 2003, Seishin Shinkeigaku Zasshi, V105, P1239
   Jackson AJ, 2020, ACTA PSYCHIAT SCAND, V142, P18, DOI 10.1111/acps.13140
   Joseph J, 2017, FRONT NEUROSCI-SWITZ, V11, DOI 10.3389/fnins.2017.00155
   Kaelberer MM, 2018, SCIENCE, V361, P1219, DOI 10.1126/science.aat5236
   Kalani A, 2014, J MOL NEUROSCI, V52, P202, DOI 10.1007/s12031-013-0122-5
   Kalaydjian AE, 2006, ACTA PSYCHIAT SCAND, V113, P82, DOI 10.1111/j.1600-0447.2005.00687.x
   Kale A, 2010, PSYCHIAT RES, V175, P47, DOI 10.1016/j.psychres.2009.01.013
   Kastorini CM, 2011, J AM COLL CARDIOL, V57, P1299, DOI 10.1016/j.jacc.2010.09.073
   KAY SR, 1987, PSYCHIAT DEV, V5, P79
   Kelly DL, 2018, BRAIN BEHAV IMMUN, V69, P57, DOI 10.1016/j.bbi.2017.10.020
   Kelly JR, 2015, FRONT CELL NEUROSCI, V9, DOI 10.3389/fncel.2015.00392
   Khandaker GM, 2016, PSYCHOPHARMACOLOGY, V233, P1559, DOI 10.1007/s00213-015-3975-1
   Khandaker GM, 2015, LANCET PSYCHIAT, V2, P258, DOI 10.1016/S2215-0366(14)00122-9
   Kim Chang H, 2014, Immune Netw, V14, P277, DOI 10.4110/in.2014.14.6.277
   Kirkpatrick B, 2013, SCHIZOPHRENIA BULL, V39, P1174, DOI 10.1093/schbul/sbt141
   Lawrence D, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f2539
   Levine J, 2006, BIOL PSYCHIAT, V60, P265, DOI 10.1016/j.biopsych.2005.10.009
   Levinta A, 2018, ADV NUTR, V9, P824, DOI 10.1093/advances/nmy056
   Lopez-Garcia E, 2004, AM J CLIN NUTR, V80, P1029, DOI 10.1093/ajcn/80.4.1029
   Mantere O, 2019, J PSYCHIATR RES, V109, P18, DOI 10.1016/j.jpsychires.2018.11.008
   Marques TR, 2019, PSYCHOL MED, V49, P2186, DOI 10.1017/S0033291718003057
   Martins-de-Souza D, 2011, ANTIOXID REDOX SIGN, V15, P2067, DOI 10.1089/ars.2010.3459
   Mercadante MT, 2000, AM J PSYCHIAT, V157, P2036, DOI 10.1176/appi.ajp.157.12.2036
   Miller BJ, 2011, BIOL PSYCHIAT, V70, P663, DOI 10.1016/j.biopsych.2011.04.013
   Minihane AM, 2015, BRIT J NUTR, V114, P999, DOI 10.1017/S0007114515002093
   Monji A, 2013, PROG NEURO-PSYCHOPH, V42, P115, DOI 10.1016/j.pnpbp.2011.12.002
   Monji A, 2009, PSYCHIAT CLIN NEUROS, V63, P257, DOI 10.1111/j.1440-1819.2009.01945.x
   Müller N, 2018, SCHIZOPHRENIA BULL, V44, P973, DOI 10.1093/schbul/sby024
   Mueller-Stierlin Annabel Sandra, 2016, German Clinical Trials Register
   Nielsen PR, 2014, SCHIZOPHRENIA BULL, V40, P1526, DOI 10.1093/schbul/sbt200
   Noble EE, 2017, FRONT BEHAV NEUROSCI, V11, DOI 10.3389/fnbeh.2017.00009
   O'Carroll R., 2000, Advances in Psychiatric Treatment, V6, P161, DOI DOI 10.1192/APT.6.3.161
   Orlovska-Waast S, 2019, MOL PSYCHIATR, V24, P869, DOI 10.1038/s41380-018-0220-4
   Patel Krishna R, 2014, P T, V39, P638
   Pillinger T, 2017, JAMA PSYCHIAT, V74, P261, DOI 10.1001/jamapsychiatry.2016.3803
   Pollak TA, 2020, LANCET PSYCHIAT, V7, P123, DOI 10.1016/S2215-0366(19)30527-9
   Radhakrishnan R, 2017, SCHIZOPHRENIA BULL, V43, P693, DOI 10.1093/schbul/sbx057
   Rajasekaran A, 2015, NEUROSCI BIOBEHAV R, V48, P10, DOI 10.1016/j.neubiorev.2014.11.005
   Rea K, 2020, NEUROPSYCHOBIOLOGY, V79, P50, DOI 10.1159/000504495
   Ruusunen Anu, 2019, Ketogenic Diet for Psychotic Disorders (PsyDiet)
   Ryan Jackson W, 2015, Clin Biochem Rev, V36, P53
   Saha S, 2006, ACTA PSYCHIAT SCAND, V114, P36, DOI 10.1111/j.1600-0447.2005.00742.x
   Sarnyai Z, 2019, CURR OPIN PSYCHIATR, V32, P394, DOI 10.1097/YCO.0000000000000535
   Sarris J, 2015, LANCET PSYCHIAT, V2, P271, DOI 10.1016/S2215-0366(14)00051-0
   Schwarz E, 2018, SCHIZOPHR RES, V192, P398, DOI 10.1016/j.schres.2017.04.017
   Schwingshackl L, 2014, NUTR METAB CARDIOVAS, V24, P929, DOI 10.1016/j.numecd.2014.03.003
   Sender R, 2016, PLOS BIOL, V14, DOI 10.1371/journal.pbio.1002533
   Severance EG, 2017, BRAIN BEHAV IMMUN, V62, P41, DOI 10.1016/j.bbi.2016.11.019
   Sharon G, 2016, CELL, V167, P915, DOI 10.1016/j.cell.2016.10.027
   Shen Y, 2018, SCHIZOPHR RES, V197, P470, DOI 10.1016/j.schres.2018.01.002
   Shen ZH, 2018, WORLD J GASTROENTERO, V24, P5, DOI 10.3748/wjg.v24.i1.5
   Singh DP, 2018, EUR J NUTR, V57, P2897, DOI 10.1007/s00394-017-1561-5
   Strandwitz P, 2018, BRAIN RES, V1693, P128, DOI 10.1016/j.brainres.2018.03.015
   Strik W, 2010, NEUROPSYCHOBIOLOGY, V61, P197, DOI 10.1159/000297737
   Teasdale SB, 2017, J HUM NUTR DIET, V30, P545, DOI 10.1111/jhn.12473
   Teasdale SB, 2017, ACTA PSYCHIAT SCAND, V135, P180, DOI 10.1111/acps.12670
   Teasdale SB, 2019, OBES RES CLIN PRACT, V13, P214, DOI 10.1016/j.orcp.2019.02.003
   Teasdale SB, 2019, BRIT J PSYCHIAT, V214, P251, DOI 10.1192/bjp.2019.20
   Teasdale SB, 2017, BRIT J PSYCHIAT, V210, P110, DOI 10.1192/bjp.bp.115.177139
   Teasdale SB, 2016, BRIT J NUTR, V115, P1987, DOI 10.1017/S0007114516001033
   Tomaka J., 2017, Curr. Prob. Psychiatr., V18, P9
   Tomioka Y, 2018, J PSYCHIATR NEUROSCI, V43, P194, DOI 10.1503/jpn.170053
   Uher R, 2017, WORLD PSYCHIATRY, V16, P121, DOI 10.1002/wps.20436
   Valipour G, 2014, J CLIN ENDOCR METAB, V99, P3863, DOI 10.1210/jc.2014-1887
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vassos E, 2012, SCHIZOPHRENIA BULL, V38, P1118, DOI 10.1093/schbul/sbs096
   Wang AK, 2018, SCHIZOPHRENIA BULL, V44, P75, DOI 10.1093/schbul/sbx035
   Wang D, 2016, PSYCHIAT RES, V235, P83, DOI 10.1016/j.psychres.2015.11.045
   Wang YP, 2019, TROP J PHARM RES, V18, P897, DOI 10.4314/tjpr.v18i4.30
   Wigand ME, 2018, PSYCHOPATHOLOGY, V51, P186, DOI 10.1159/000486897
   World Health Organization, 2018, Management of physical health conditions in adults with severe mental disorders WHO GUIDELINES Internet
   Xu RH, 2020, BRAIN BEHAV IMMUN, V85, P120, DOI 10.1016/j.bbi.2019.06.039
   Yuan XX, 2019, BIOCHEM BIOPH RES CO, V512, P373, DOI 10.1016/j.bbrc.2019.02.152
   Yuan XX, 2018, SCHIZOPHR RES, V201, P299, DOI 10.1016/j.schres.2018.05.017
   Zheng P, 2019, SCI ADV, V5, DOI 10.1126/sciadv.aau8317
   Zhu F, 2020, MOL PSYCHIATR, V25, P2905, DOI 10.1038/s41380-019-0475-4
NR 122
TC 28
Z9 30
U1 4
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2666-3546
J9 BRAIN BEHAV IMMUN-HL
JI Brain Behav. Immun.-Health
PD MAY
PY 2020
VL 5
AR 100070
DI 10.1016/j.bbih.2020.100070
PG 9
WC Immunology; Neurosciences; Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA R0LC8
UT WOS:001061332800003
PM 34589852
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tang, WF
   Zhan, WQ
   Chen, Q
AF Tang, Weifeng
   Zhan, Wenqiang
   Chen, Qian
TI The mediating role of telomere length in multi-pollutant exposure
   associated with metabolic syndrome in adults
SO ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
LA English
DT Article
DE Multi-pollutant; Telomere length; Metabolic syndrome; Mediating effect
ID POLYCYCLIC AROMATIC-HYDROCARBONS; OXIDATIVE STRESS; DNA ADDUCTS;
   METHYLATION; ADIPOCYTES; PREVALENCE; MECHANISM; CHEMICALS; DAMAGE; CELLS
AB Metabolic syndrome is a chronic and complex disease characterized by environmental and genetic factors. However, the underlying mechanisms remain unclear. This study assessed the relationship between exposure to a mixture of environmental chemicals and metabolic syndrome (MetS) and further examined whether telomere length (TL) moderated these relationships. A total of 1265 adults aged > 20 years participated in the study. Data on multiple pollutants (polycyclic aromatic hydrocarbons, phthalates, and metals), MetS, leukocyte telomere length (LTL), and confounders were provided in the 2001-2002 National Health and Nutrition Examination Survey. The correlations between multi-pollutant exposure, TL, and MetS in the males and females were separately assessed using principal component analysis (PCA), logistic and extended linear regression models, Bayesian kernel machine regression (BKMR), and mediation analysis. Four factors were generated in PCA that accounted for 76.2% and 77.5% of the total environmental pollutants in males and females, respectively. The highest quantiles of PC2 and PC4 were associated with the risk of TL shortening (P < 0.05). We observed that the relationship between PC2, PC4, and MetS risk was significant in the participants with median TL levels (P for trend = 0.04 for PC2, and P for trend = 0.01 for PC4). Furthermore, mediation analysis revealed that TL could explain 26.1% and 17.1% of the effects of PC2 and PC4 associated with MetS in males, respectively. The results of BKMR model revealed that these associations were mainly driven by 1-PYE (cPIP = 0.65) and Cd (cPIP = 0.29) in PC2. Meanwhile, TL could explain 17.7% of the mediation effects of PC2 associated with MetS in the females. However, the relationships between pollutants and MetS were sparse and inconsistent in the females. Our findings suggest that the effects of the risk of MetS associated with mixed exposure to multiple pollutants are mediated by TL, and this mediating effect in the males is more pronounced than that in the females.
C1 [Tang, Weifeng; Zhan, Wenqiang; Chen, Qian] Shanghai Jiao Tong Univ, Xinhua Hosp, Shanghai Key Lab Childrens Environm Hlth, Minist Educ,Sch Med, Shanghai, Peoples R China.
   [Zhan, Wenqiang] Shanghai Jiao Tong Univ, Sch Publ Hlth, Sch Med, Shanghai, Peoples R China.
C3 Ministry of Education - China; Shanghai Jiao Tong University; Shanghai
   Jiao Tong University
RP Chen, Q (corresponding author), Shanghai Jiao Tong Univ, Xinhua Hosp, Shanghai Key Lab Childrens Environm Hlth, Minist Educ,Sch Med, Shanghai, Peoples R China.
EM chenqian01@xinhuamed.com.cn
FU National Natural Science Foundation of China [81803244]
FX This study was partially funded by the National Natural Science
   Foundation of China (81803244).
CR Adli A, 2021, ENVIRON RES, V195, DOI 10.1016/j.envres.2021.110757
   Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Aubert G, 2008, PHYSIOL REV, V88, P557, DOI 10.1152/physrev.00026.2007
   Baird WM, 2005, ENVIRON MOL MUTAGEN, V45, P106, DOI 10.1002/em.20095
   Barnes RP, 2019, MECH AGEING DEV, V177, P37, DOI 10.1016/j.mad.2018.03.013
   Benjamin S, 2017, J HAZARD MATER, V340, P360, DOI 10.1016/j.jhazmat.2017.06.036
   Borm PJA, 2005, TOXICOL APPL PHARM, V205, P157, DOI 10.1016/j.taap.2004.10.020
   Cawthon RM, 2002, NUCLEIC ACIDS RES, V30, DOI 10.1093/nar/30.10.e47
   Chen L, 2022, BMC MED, V20, DOI 10.1186/s12916-022-02403-3
   Choi W, 2017, INT J HYG ENVIR HEAL, V220, P29, DOI 10.1016/j.ijheh.2016.10.002
   Coull BA., 2015, Res. Rep. Health Eff. Inst, P5
   Cowell W, 2020, ENVIRON RES, V190, DOI 10.1016/j.envres.2020.110009
   Drakvik E, 2020, ENVIRON INT, V134, DOI 10.1016/j.envint.2019.105267
   Duty SM, 2005, ENVIRON HEALTH PERSP, V113, P1530, DOI 10.1289/ehp.8083
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Fu Y, 2019, CHEMOSPHERE, V224, P48, DOI 10.1016/j.chemosphere.2019.02.114
   Gao ZG, 2020, NAT METAB, V2, DOI 10.1038/s42255-020-00320-4
   Gavia-García G, 2021, BIOLOGY-BASEL, V10, DOI 10.3390/biology10040253
   Ge XT, 2021, SCI TOTAL ENVIRON, V760, DOI 10.1016/j.scitotenv.2020.143906
   Gearhart-Serna LM, 2021, ENVIRON RES, V201, DOI 10.1016/j.envres.2021.111614
   Ghaedrahmat Z, 2021, J TRACE ELEM MED BIO, V66, DOI 10.1016/j.jtemb.2021.126757
   Giraud-Panis MJ, 2018, CELL RES, V28, P7, DOI 10.1038/cr.2017.152
   Grundy SM, 2004, CIRCULATION, V110, P227, DOI 10.1161/01.CIR.0000133317.49796.0E
   Haverinen E, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph182413047
   Heindel JJ, 2017, REPROD TOXICOL, V68, P3, DOI 10.1016/j.reprotox.2016.10.001
   Hellman LM, 2014, NUCLEIC ACIDS RES, V42, P9781, DOI 10.1093/nar/gku659
   Hendryx M, 2018, ENVIRON RES, V160, P115, DOI 10.1016/j.envres.2017.09.024
   Henkler Frank, 2012, Exp Suppl, V101, P107, DOI 10.1007/978-3-7643-8340-4_5
   Herrera-Moreno JF, 2022, ENVIRON RES, V205, DOI 10.1016/j.envres.2021.112577
   Hsu JW, 2021, FOOD CHEM TOXICOL, V156, DOI 10.1016/j.fct.2021.112439
   Hu H, 2015, SCI TOTAL ENVIRON, V505, P56, DOI 10.1016/j.scitotenv.2014.09.085
   Jeng HA, 2011, OCCUP ENVIRON MED, V68, P653, DOI 10.1136/oem.2010.055020
   Jin M, 2021, SCI TOTAL ENVIRON, V776, DOI 10.1016/j.scitotenv.2021.145963
   Johnson Clifford L, 2014, Vital Health Stat 2, P1
   Kaminska MS, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17145033
   Kassotis CD, 2021, ADV PHARMACOL, V92, P1, DOI 10.1016/bs.apha.2021.03.005
   Kim KH, 2013, ENVIRON INT, V60, P71, DOI 10.1016/j.envint.2013.07.019
   Kortenkamp A, 2018, SCIENCE, V361, P224, DOI 10.1126/science.aat9219
   Lapid K, 2017, ADIPOCYTE, V6, P176, DOI 10.1080/21623945.2017.1299298
   Lee HS, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0193323
   Li K, 2021, ENVIRON RES, V202, DOI 10.1016/j.envres.2021.111747
   Lin J, 2010, J IMMUNOL METHODS, V352, P71, DOI 10.1016/j.jim.2009.09.012
   Liu SM, 2018, J DIABETES, V10, P428, DOI 10.1111/1753-0407.12517
   Masi S, 2011, FREE RADICAL BIO MED, V50, P730, DOI 10.1016/j.freeradbiomed.2010.12.031
   McGruer V, 2021, ENVIRON TOXICOL CHEM, V40, P1586, DOI 10.1002/etc.5002
   Mesch VR, 2006, CLIMACTERIC, V9, P40, DOI 10.1080/13697130500487331
   Messerlian C, 2018, HUM REPROD OPEN, V2018, DOI 10.1093/hropen/hoy001
   Momeni HR, 2020, HUM EXP TOXICOL, V39, P653, DOI 10.1177/0960327119895564
   Muñoz-Lorente MA, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-12664-x
   Napier CE, 2010, BBA-MOL CELL RES, V1803, P1142, DOI 10.1016/j.bbamcr.2010.06.010
   Net S, 2015, ENVIRON SCI TECHNOL, V49, P4019, DOI 10.1021/es505233b
   O'ROURKE N., 2013, A step-by-step approach to using SAS for factor analysis and structural equation modeling
   Peng XM, 2021, J RES MED SCI, V26, DOI 10.4103/jrms.JRMS_793_20
   Révész D, 2014, J CLIN ENDOCR METAB, V99, P4607, DOI 10.1210/jc.2014-1851
   Richter T, 2007, EXP GERONTOL, V42, P1039, DOI 10.1016/j.exger.2007.08.005
   Rizvi Saliha, 2014, Curr Aging Sci, V7, P161
   Salpea KD, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0073756
   Santoro A, 2021, CELL METAB, V33, P748, DOI 10.1016/j.cmet.2021.03.019
   Sas K, 2018, MOLECULES, V23, DOI 10.3390/molecules23010191
   Scinicariello F, 2016, EBIOMEDICINE, V6, P96, DOI 10.1016/j.ebiom.2016.02.027
   Shih YL, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph191610458
   Shim YH, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16040671
   Shimada T, 2013, CHEM RES TOXICOL, V26, P529, DOI 10.1021/tx3004906
   Smith AR, 2021, ENVIRON HEALTH PERSP, V129, DOI 10.1289/EHP9294
   Srivastava Shweta, 2022, Open J Air Pollut, V11, P29, DOI 10.4236/ojap.2022.112003
   Stojanoska MM, 2017, ENDOCRINE, V55, P666, DOI 10.1007/s12020-016-1158-4
   Sun LX, 2015, NUCLEIC ACIDS RES, V43, P6334, DOI 10.1093/nar/gkv598
   Sun S, 2022, SCI TOTAL ENVIRON, V829, DOI 10.1016/j.scitotenv.2022.154597
   Urut F, 2021, BIOL TRACE ELEM RES, V199, P3700, DOI 10.1007/s12011-020-02491-3
   Valeri L, 2017, ENVIRON HEALTH PERSP, V125, DOI [10.1289/EHP614, 10.1289/ehp614]
   Valeri L, 2013, PSYCHOL METHODS, V18, P137, DOI 10.1037/a0031034
   von Zglinicki T, 2002, TRENDS BIOCHEM SCI, V27, P339, DOI 10.1016/S0968-0004(02)02110-2
   Wang F, 2022, ENVIRON SCI POLLUT R, V29, P80491, DOI 10.1007/s11356-022-21391-8
   Wang Guoying, 2014, Curr Environ Health Rep, V1, P78
   Wang VA, 2021, J EXPO SCI ENV EPID, V31, P224, DOI 10.1038/s41370-020-00279-0
   Wils RS, 2021, NANOTOXICOLOGY, V15, P661, DOI 10.1080/17435390.2021.1910359
   Wong WPS, 2021, TOXICOL APPL PHARM, V433, DOI 10.1016/j.taap.2021.115756
   Xu J, 2021, REDOX BIOL, V38, DOI 10.1016/j.redox.2020.101776
   Yang X, 2022, SCI TOTAL ENVIRON, V840, DOI 10.1016/j.scitotenv.2022.156673
   Yao F, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124475
   Yavasoglu NÜK, 2014, ENVIRON TOXICOL, V29, P345, DOI 10.1002/tox.21813
   Yu YX, 2021, J HAZARD MATER, V401, DOI 10.1016/j.jhazmat.2020.123390
   Yun Y, 2019, SCI TOTAL ENVIRON, V660, P1602, DOI 10.1016/j.scitotenv.2018.12.476
   Zawia A, 2021, ARTERIOSCL THROM VAS, V41, P430, DOI 10.1161/ATVBAHA.120.314639
   Zhang B, 2021, CHEMOSPHERE, V266, DOI 10.1016/j.chemosphere.2020.129111
   Zhang B, 2020, CHEMOSPHERE, V247, DOI 10.1016/j.chemosphere.2020.125880
   Zhang YZ, 2019, BIOMED ENVIRON SCI, V32, P406, DOI 10.3967/bes2019.055
   Zhao L, 2022, ENVIRON POLLUT, V307, DOI 10.1016/j.envpol.2022.119479
   Zhou FK, 2019, ENVIRON INT, V133, DOI 10.1016/j.envint.2019.105192
   Zhou JL, 2022, CHEMOSPHERE, V291, DOI 10.1016/j.chemosphere.2021.132953
NR 90
TC 0
Z9 0
U1 2
U2 15
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0944-1344
EI 1614-7499
J9 ENVIRON SCI POLLUT R
JI Environ. Sci. Pollut. Res.
PD JUL
PY 2023
VL 30
IS 34
BP 82068
EP 82082
DI 10.1007/s11356-023-28017-7
EA JUN 2023
PG 15
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA T9KN2
UT WOS:001011289600006
PM 37322399
DA 2025-06-11
ER

PT J
AU Goh, AMY
   Westphal, A
   Daws, T
   Gascoigne-Cohen, S
   Hamilton, B
   Lautenschlager, NT
AF Goh, Anita M. Y.
   Westphal, Alissa
   Daws, Teresa
   Gascoigne-Cohen, Sophie
   Hamilton, Bridget
   Lautenschlager, Nicola T.
TI A retrospective study of medical comorbidities in psychogeriatric
   patients
SO PSYCHOGERIATRICS
LA English
DT Article
DE ageing; comorbidities; medical illness; mental illness; psychogeriatric
ID CATIE SCHIZOPHRENIA TRIAL; SERIOUS MENTAL-ILLNESS;
   PSYCHIATRIC-INPATIENTS; METABOLIC SYNDROME; PHYSICAL ILLNESS; HEALTH;
   PREVALENCE; OBESITY; COMPLICATIONS; INDIVIDUALS
AB Background: This study contributes further research into the assessment and treatment of older psychiatric patients with medical comorbidities.
   Methods: A retrospective file audit was conducted at the acute inpatient psychogeriatric unit of St Vincent's Aged Mental Health Service, Melbourne, in order to determine the prevalence of certain medical comorbidities and the nature of medical interventions provided for psychogeriatric inpatients.
   Results: This study, investigating 165 admissions into an acute inpatient psychogeriatric unit, highlights that psychiatric and medical comorbidities are routine in this population: the vast majority (91.5%) of all inpatients had at least one medical comorbidity.
   Conclusions: As the population ages, psychogeriatric wards are likely to see more of the oldest-olds, who are likely to have comorbid medical illnesses. Currently, appropriate detection, investigation, and management of these illnesses are often suboptimal and can affect quality of life, increase mortality, and complicate treatment. This paper adds to the literature about the need for integrating medical and psychiatric care to create a more comprehensive strategy for treating the older person with psychiatric illness.
C1 [Goh, Anita M. Y.; Westphal, Alissa; Lautenschlager, Nicola T.] Univ Melbourne, Dept Psychiat, Acad Unit Psychiat Old Age, Melbourne, Vic, Australia.
   [Daws, Teresa; Hamilton, Bridget] Univ Melbourne, Dept Nursing, Melbourne, Vic, Australia.
   [Goh, Anita M. Y.; Gascoigne-Cohen, Sophie; Hamilton, Bridget; Lautenschlager, Nicola T.] St Vincents Hosp, St Vincents Aged Mental Hlth Serv, Melbourne, Vic, Australia.
   [Goh, Anita M. Y.] Royal Melbourne Hosp, Melbourne Neuropsychiat Ctr, Neuropsychiat Unit, Melbourne, Vic, Australia.
   [Lautenschlager, Nicola T.] Univ Western Australia, WA Ctr Hlth & Ageing, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia.
C3 University of Melbourne; University of Melbourne; St Vincent's Health;
   St Vincent's Hospital Melbourne; NSW Health; St Vincents Hospital
   Sydney; Melbourne Health; Royal Melbourne Hospital; University of
   Western Australia
RP Goh, AMY (corresponding author), St George Hosp, Acad Unit Psychiat Old Age, Normanby Unit, 283 Cotham Rd, Kew, Vic 3101, Australia.
EM goha@unimelb.edu.au
RI Hamilton, Bridget/C-2788-2013; Goh, Anita/AAA-7278-2022
OI Lautenschlager, Nicola/0000-0003-4850-7794; Hamilton,
   Bridget/0000-0001-8711-7559; Goh, Anita/0000-0003-0159-5926
CR Adamis D, 2000, INT J GERIATR PSYCH, V15, P248, DOI 10.1002/(SICI)1099-1166(200003)15:3<248::AID-GPS102>3.0.CO;2-L
   [Anonymous], 2021, Period Products (Free Provision) (Scotland) Act 2021: Guidance for Responsible Bodies'
   Bartels SJ, 2004, J AM GERIATR SOC, V52, pS249, DOI 10.1111/j.1532-5415.2004.52601.x
   Brown S, 2000, BRIT J PSYCHIAT, V177, P212, DOI 10.1192/bjp.177.3.212
   Carney RM, 2003, BIOL PSYCHIAT, V54, P241, DOI 10.1016/S0006-3223(03)00111-2
   Carson N, 2010, PSYCHIAT SERV, V61, P32, DOI 10.1176/appi.ps.61.1.32
   Cournos Francine, 2005, World Psychiatry, V4, P135
   Daumit GL, 2003, J NERV MENT DIS, V191, P799, DOI 10.1097/01.nmd.0000100923.20188.2d
   Davidson S, 2001, AUST NZ J PSYCHIAT, V35, P196, DOI 10.1046/j.1440-1614.2001.00877.x
   DAVIDSON S, 2000, AUSTRALAS PSYCHIATRY, V8, P31, DOI DOI 10.1046/J.1440-1665.2000.00234.X
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   Dickerson FB, 2006, ACTA PSYCHIAT SCAND, V113, P306, DOI 10.1111/j.1600-0447.2005.00637.x
   Drew L, 2007, AUSTRALAS PSYCHIATRY, V15, P320, DOI 10.1080/10398560701320105
   Gierz Monika, 1993, Am J Geriatr Psychiatry, V1, P165, DOI 10.1097/00019442-199300120-00010
   Gray R, 2009, INT J MENT HEALTH NU, V18, P299, DOI 10.1111/j.1447-0349.2009.00640.x
   John AP, 2009, MED J AUSTRALIA, V190, P176, DOI 10.5694/j.1326-5377.2009.tb02342.x
   Lambert TJR, 2009, MED J AUSTRALIA, V190, pS39
   Lawrence DM, 2003, BRIT J PSYCHIAT, V182, P31, DOI 10.1192/bjp.182.1.31
   Leung MW, 2010, PSYCHOSOMATICS, V51, P498, DOI 10.1176/appi.psy.51.6.498
   Loi S, 2011, CURR OPIN PSYCHIATR, V24, P355, DOI 10.1097/YCO.0b013e3283454d9e
   Lyketsos CG, 2002, PSYCHOSOMATICS, V43, P24, DOI 10.1176/appi.psy.43.1.24
   McEvoy JP, 2005, SCHIZOPHR RES, V80, P19, DOI 10.1016/j.schres.2005.07.014
   Nasrallah HA, 2006, SCHIZOPHR RES, V86, P15, DOI 10.1016/j.schres.2006.06.026
   PARMELEE PA, 1995, J AM GERIATR SOC, V43, P130, DOI 10.1111/j.1532-5415.1995.tb06377.x
   Robson D, 2007, INT J NURS STUD, V44, P457, DOI 10.1016/j.ijnurstu.2006.07.013
   SHELINE YI, 1990, GEN HOSP PSYCHIAT, V12, P396, DOI 10.1016/0163-8343(90)90008-Z
   Sokal J, 2004, J NERV MENT DIS, V192, P421, DOI 10.1097/01.nmd.0000130135.78017.96
   Tucker S, 2009, J INTERPROF CARE, V23, P341, DOI 10.1080/13561820902739833
   Wallace B, 1998, AUST NZ J PSYCHIAT, V32, P82, DOI 10.3109/00048679809062711
   Zubenko GS, 1997, BIOL PSYCHIAT, V41, P724, DOI 10.1016/S0006-3223(96)00337-X
NR 30
TC 10
Z9 10
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1346-3500
EI 1479-8301
J9 PSYCHOGERIATRICS
JI Psychogeriatrics
PD JAN
PY 2016
VL 16
IS 1
BP 12
EP 19
DI 10.1111/psyg.12111
PG 8
WC Geriatrics & Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Psychiatry
GA DH7ES
UT WOS:000372955400002
PM 25737391
DA 2025-06-11
ER

PT J
AU Shigehara, K
   Izumi, K
   Mizokami, A
   Namiki, M
AF Shigehara, Kazuyoshi
   Izumi, Koji
   Mizokami, Atsushi
   Namiki, Mikio
TI Testosterone Deficiency and Nocturia: A Review
SO WORLD JOURNAL OF MENS HEALTH
LA English
DT Review
DE Hypogonadism; Lower urinary tract symptoms; Nocturia; Testosterone
ID LOWER URINARY-TRACT; LATE-ONSET HYPOGONADISM; REPLACEMENT THERAPY; SERUM
   TESTOSTERONE; METABOLIC SYNDROME; SEX-HORMONES; MEN; SLEEP; SYMPTOMS;
   PROSTATE
AB Nocturia causes lack of sleep and excessive daytime somnolence, reducing overall well-being, vitality, productivity, and mental health. Nocturia is significantly associated with testosterone deficiency, lower urinary tract symptoms (LUTS), and sleep disorders. The development of LUTS is commonly associated with testosterone deficiency in elderly men, and recent studies have suggested that testosterone has an ameliorative effect on nocturia. In hypogonadal men with nocturia, a negative feedback cycle can arise, in which testosterone deficiency leads to the development of nocturia, and nocturia contributes to the decline in testosterone levels. Therefore, patients with nocturia should receive appropriate treatment in order to improve their quality of life. Nocturia is generally treated by restricting nighttime water intake, as well as by the administration of medications, such as alpha-1 blockers, anticholinergic drugs, and desmopressin. Testosterone replacement therapy (TRT) is used worldwide as a treatment for many hypogonadal conditions. TRT represents an alternative treatment option for nocturia in hypogonadal men. However, limited information is currently available regarding the effects of TRT on nocturia in hypogonadal men, and further studies are required to reach more definitive conclusions.
C1 [Shigehara, Kazuyoshi; Izumi, Koji; Mizokami, Atsushi; Namiki, Mikio] Kanazawa Univ, Grad Sch Med Sci, Dept Integrat Canc Therapy & Urol, 13-1 Takaramachi, Kanazawa, Ishikawa 9208641, Japan.
   [Namiki, Mikio] Hasegawa Hosp, Dept Urol, Toyama, Japan.
C3 Kanazawa University
RP Shigehara, K (corresponding author), Kanazawa Univ, Grad Sch Med Sci, Dept Integrat Canc Therapy & Urol, 13-1 Takaramachi, Kanazawa, Ishikawa 9208641, Japan.
EM kshigehara0415@yahoo.co.jp
CR Amano T, 2010, AGING MALE, V13, P242, DOI 10.3109/13685538.2010.487552
   Asplund R, 2005, BJU INT, V95, P816, DOI 10.1111/j.1464-410X.2005.05407.x
   Asplund R, 2002, BJU INT, V90, P533, DOI 10.1046/j.1464-410X.2002.02975.x
   Azadzoi KM, 1999, J UROLOGY, V162, P1768, DOI 10.1016/S0022-5347(05)68236-5
   Barrett-Connor E, 2008, J CLIN ENDOCR METAB, V93, P2602, DOI 10.1210/jc.2007-2622
   Bassil Nazem, 2009, Ther Clin Risk Manag, V5, P427
   FitzGerald MP, 2007, J UROLOGY, V177, P1385, DOI 10.1016/j.juro.2006.11.057
   Hanafy HM, 2007, J SEX MED, V4, P1241, DOI 10.1111/j.1743-6109.2007.00553.x
   Harman SM, 2001, J CLIN ENDOCR METAB, V86, P724, DOI 10.1210/jc.86.2.724
   HERZBERG NH, 1989, J ENDOCRINOL, V123, P59, DOI 10.1677/joe.0.1230059
   Homma Y, 2006, UROLOGY, V68, P560, DOI 10.1016/j.urology.2006.03.035
   Huhtaniemi I, 2014, ASIAN J ANDROL, V16, P192, DOI 10.4103/1008-682X.122336
   IKEDA Y, 1993, ENDOCR J, V40, P387, DOI 10.1507/endocrj.40.387
   Jeh SU, 2017, ANDROLOGY-US, V5, P58, DOI 10.1111/andr.12270
   Kalinchenko S, 2008, AGING MALE, V11, P57, DOI 10.1080/13685530801953994
   Karazindiyanoglu S, 2008, AGING MALE, V11, P146, DOI 10.1080/13685530802290438
   Kim JW, 2014, INT J UROL, V21, P518, DOI 10.1111/iju.12345
   Kim JW, 2014, UROLOGY, V83, P837, DOI 10.1016/j.urology.2013.12.060
   Kim MK, 2012, AGING MALE, V15, P90, DOI 10.3109/13685538.2012.659715
   Kim Sun-Ouck, 2011, Int Neurourol J, V15, P82, DOI 10.5213/inj.2011.15.2.82
   Ko YH, 2013, WORLD J MENS HEALTH, V31, P47, DOI 10.5534/wjmh.2013.31.1.47
   Kobelt G, 2003, BJU INT, V91, P190, DOI 10.1046/j.1464-410X.2003.04062.x
   Laaksonen DE, 2004, DIABETES CARE, V27, P1036, DOI 10.2337/diacare.27.5.1036
   Liao CH, 2011, UROLOGY, V78, P631, DOI 10.1016/j.urology.2011.05.033
   Liu HY, 2016, INT UROL NEPHROL, V48, P1209, DOI 10.1007/s11255-016-1310-3
   Liu PY, 2003, J CLIN ENDOCR METAB, V88, P3605, DOI 10.1210/jc.2003-030236
   Luboshitzky R, 2001, J CLIN ENDOCR METAB, V86, P1134, DOI 10.1210/jc.86.3.1134
   Lunenfeld B, 2015, AGING MALE, V18, P5, DOI 10.3109/13685538.2015.1004049
   McVary KT, 2005, EUR UROL, V47, P838, DOI 10.1016/j.eururo.2005.02.001
   Mitterberger M, 2007, BJU INT, V99, P830, DOI 10.1111/j.1464-410X.2006.06735.x
   Nakagawa H, 2010, J UROLOGY, V184, P1413, DOI 10.1016/j.juro.2010.05.093
   Oh MM, 2012, ASIAN J ANDROL, V14, P330, DOI 10.1038/aja.2011.153
   Pak TR, 2007, ENDOCRINOLOGY, V148, P3371, DOI 10.1210/en.2007-0086
   Paul KN, 2009, NEUROSCI LETT, V463, P239, DOI 10.1016/j.neulet.2009.07.081
   PAVO I, 1995, LIFE SCI, V56, P1215, DOI 10.1016/0024-3205(95)00061-A
   Saad F, 2008, J ANDROL, V29, P102, DOI 10.2164/jandrol.107.002774
   Schmid SM, 2012, CLIN ENDOCRINOL, V77, P749, DOI 10.1111/j.1365-2265.2012.04419.x
   Shigehara K, 2015, AGING MALE, V18, P169, DOI 10.3109/13685538.2015.1038990
   Shigehara K, 2011, KOREAN J UROL, V52, P657, DOI 10.4111/kju.2011.52.10.657
   Shigehara K, 2011, AGING MALE, V14, P53, DOI 10.3109/13685538.2010.518178
   Tikkinen KAO, 2006, J UROLOGY, V175, P596, DOI 10.1016/S0022-5347(05)00245-4
   van Kerrebroeck P, 2002, NEUROUROL URODYNAM, V21, P179, DOI 10.1002/nau.10053
   Wittert G, 2014, ASIAN J ANDROL, V16, P262, DOI 10.4103/1008-682X.122586
   Wu Y, 2017, ASIAN J ANDROL, V19, P230, DOI 10.4103/1008-682X.171575
   Yassin A, 2016, AGING MALE, V19, P64, DOI 10.3109/13685538.2015.1126573
   Yoo SS, 2010, KOREAN J UROL, V51, P757, DOI 10.4111/kju.2010.51.11.757
   Yoshimura K, 2004, INT J UROL, V11, P282, DOI 10.1111/j.1442-2042.2004.00791.x
NR 47
TC 22
Z9 22
U1 0
U2 4
PU KOREAN SOC SEXUAL MEDICINE & ANDROLOGY
PI GWANGJU
PA DEPT UROLOGY, CHONNAM NATL UNIV MEDICAL SCH, 671 JEBONG-RO, DONG-GU,
   GWANGJU, 501-757, SOUTH KOREA
SN 2287-4208
EI 2287-4690
J9 WORLD J MENS HEALTH
JI World J. Mens Health
PD APR
PY 2017
VL 35
IS 1
BP 14
EP 21
DI 10.5534/wjmh.2017.35.1.14
PG 8
WC Andrology; Health Care Sciences & Services; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Health Care Sciences & Services; Urology &
   Nephrology
GA FJ8ID
UT WOS:000413007700002
PM 28459143
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Alonso, HRF
   Heimer, MV
   Calado, RV
   Silva, JVFD
   Lins, RML
   Romao, DA
   Pugliesi, DMC
   dos Santos, VE Jr
AF Alonso, Herculano Ramirez Floro
   Heimer, Monica Vilela
   Calado, Rafael Vrijdags
   Silva, Joao Victor Farias da
   Lins, Renata Matos Lamenha
   Romao, Dayse Andrade
   Pugliesi, Daniela Maria Carvalho
   dos Santos Junior, Valdeci Elias
TI Sedation and its Potential Risks in Children with Autism Spectrum Due to
   Drug Overlaps: A Critical Review
SO PESQUISA BRASILEIRA EM ODONTOPEDIATRIA E CLINICA INTEGRADA
LA English
DT Review
DE Mental Health; Autistic Disorder; Child Development; Pharmacology; Child
ID INDUCED QT PROLONGATION; TORSADE-DE-POINTES; SEROTONIN SYNDROME;
   RECEPTORS
AB Objective: To analyse pharmacological overlap in patients with autism spectrum disorder (ASD) under conscious sedation in a dental office environment, identifying any potential risks and complications. Material and Methods: A critical review was conducted by selecting articles from online databases (Pubmed and Lilacs), using a search algorithm and eligibility criteria. The Medscape (R) platform was used to verify interactions between drugs commonly used by patients with ASD and medications used for sedation in paediatric dentistry. Results: Due to their polydrug use, children with ASD are at risk of complications, namely Serotonin Syndrome (SS), Neuroleptic Malignant Syndrome (NMS), increase or decrease of the QT interval (QTi) and Torsade de Pointes (TdP), due to pre-existence of metabolic syndrome, deepening the sedation level or even leading to a decrease in the sedative capacity of the drugs used. Conclusion: It is essential to assess better drug interaction in ASD patients submitted to sedation. The severity of the disorder and the need for sedation for dental treatment are directly proportional. However, increases in sedative doses tend to increase risks and complications in children with ASD.
C1 [Alonso, Herculano Ramirez Floro; Calado, Rafael Vrijdags; Lins, Renata Matos Lamenha; Romao, Dayse Andrade; Pugliesi, Daniela Maria Carvalho; dos Santos Junior, Valdeci Elias] Univ Fed Alagoas, Sch Dent, Dept Pediat Dent, Maceio, AL, Brazil.
   [Heimer, Monica Vilela] Univ Pernambuco, Sch Dent, Dept Pediat Dent, Camaragibe, PE, Brazil.
   [Silva, Joao Victor Farias da] Univ Fed Sergipe, Dept Med, Aracaju, SE, Brazil.
C3 Universidade Federal de Alagoas; Universidade de Pernambuco (UPE);
   Universidade Federal de Sergipe
RP dos Santos, VE Jr (corresponding author), Univ Fed Alagoas, Sch Dent, Dept Pediat Dent, Maceio, AL, Brazil.
RI Lamenha-Lins, Renata/AAA-5920-2022; Heimer, Mônica/P-1135-2019
CR Aishworiya R, 2022, NEUROTHERAPEUTICS, V19, P248, DOI 10.1007/s13311-022-01183-1
   American Psychiatric Association (APA), 2014, DSM-5: Manual Diagnostico e Estatistico de Transtornos Mentais, V5, P709
   [Anonymous], 1995, Drug Interaction Checker
   [Anonymous], 2017, Autism spectrum disorders
   [Anonymous], 2005, Timothy Syndrome
   [Anonymous], 2022, Midazolam [package insert]
   [Anonymous], 2022, Hidroxizina [package insert]
   Asahi Y, 2009, ANAESTH INTENS CARE, V37, P70, DOI 10.1177/0310057X0903700101
   Ashley P, 2021, EUR ARCH PAEDIATR DE, V22, P989, DOI 10.1007/s40368-021-00660-z
   Berkenbosch JW, 2021, Pediatric Sedation Outside of the Operating Room, V3, P545
   Berloffa S, 2021, CHILDREN-BASEL, V8, DOI 10.3390/children8121201
   Birmes P, 2003, CAN MED ASSOC J, V168, P1439
   Borroto-Escuela DO, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10081902
   Carvalho MVH, 2017, Rev Med UFPR, V4, P11
   Chieh YA, 2021, RES AUTISM SPECT DIS, V86, DOI 10.1016/j.rasd.2021.101821
   Cintra P, 2008, PSILOGOS, V5, P88
   Coté CJ, 2019, PEDIATRICS, V143, DOI 10.1542/peds.2019-1000
   Criado PR, 2010, AN BRAS DERMATOL, V85, P195, DOI 10.1590/S0365-05962010000200010
   Direk MÇ, 2016, CLIN PSYCHOPHARM NEU, V14, P388, DOI 10.9758/cpn.2016.14.4.388
   Dock M, 2011, McDonald e Avery Odontopediatria para Criancas e Adolescentes, V9, P249
   Eissa N, 2018, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00304
   Endres D, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21228611
   Griffin Jr EA, 2009, Principios de Farmacologia: A Base Fisiopatologica da Farmacoterapia, V2, P203
   Hocht C, 2004, Rev Argent Cardiol, V72, P474
   Howes OD, 2018, J PSYCHOPHARMACOL, V32, P3, DOI 10.1177/0269881117741766
   Husain Z, 2010, CARDIOL J, V17, P509
   Hyman SL, 2020, PEDIATRICS, V145, DOI 10.1542/peds.2019-3447
   Ishii T, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0189318
   Khan S, 2018, CUREUS J MED SCIENCE, V10, DOI 10.7759/cureus.2421
   Lamy M, 2018, CURR PROB PEDIATR AD, V48, P250, DOI 10.1016/j.cppeds.2018.08.015
   Malamed SF, 2012, Sedacao na Odontologia, V5, P446
   Malamed SF, 2012, Sedacao Oral. Sedacao na Odontologia, V5, P95
   Martins Josiane de Macedo, 2015, Revista de Ciencias Farmaceuticas Basica e Aplicada, V36, P297
   Miyake R S, 1998, Rev Assoc Med Bras (1992), V44, P56, DOI 10.1590/S0104-42301998000100012
   Persico AM, 2021, PROG NEURO-PSYCHOPH, V110, DOI 10.1016/j.pnpbp.2021.110326
   Posey DJ, 2007, CNS DRUG REV, V13, P465, DOI 10.1111/j.1527-3458.2007.00026.x
   Pytliak M, 2011, PHYSIOL RES, V60, P15, DOI 10.33549/physiolres.931903
   Racz R, 2018, CTS-CLIN TRANSL SCI, V11, P322, DOI 10.1111/cts.12543
   Relia Sachin, 2018, Med Sci (Basel), V6, DOI 10.3390/medsci6040095
   Ribeiro S., 2006, Rev Cardiopulmonar, V17, P43
   Richelson E, 2001, MAYO CLIN PROC, V76, P511, DOI 10.4065/76.5.511
   Seo KH, 2014, KOREAN J ANESTHESIOL, V67, P421, DOI 10.4097/kjae.2014.67.6.421
   Shah RR, 2010, BRIT J PHARMACOL, V159, P58, DOI 10.1111/j.1476-5381.2009.00191.x
   Souza RAP, 2012, Rev Bras Clin Med, V10, P440
   Staikou C, 2014, BRIT J ANAESTH, V112, P217, DOI 10.1093/bja/aet412
   Standaert D G., 2009, Principios da Farmacologias - A Base Fisiopatologica da Farmacoterapia 2a Edicao, P166
   Taniguchi C., 2009, Principios de farmacologia - A base fisiopatologica da farmacoterapia, V2a, P46
   Taniguchi CM, 2009, Principios de farmacologia: A base fisiopatologica da farmacoterapia, V2, P58
   Timour Q, 2012, FRONT PHARMACOL, V3, DOI 10.3389/fphar.2012.00076
   Vo LC, 2016, J CHILD ADOL PSYCHOP, V26, P900, DOI 10.1089/cap.2016.0090
   Zeltser D, 2003, MEDICINE, V82, P282, DOI 10.1097/00005792-200307000-00007
NR 51
TC 0
Z9 0
U1 2
U2 3
PU ASSOC APOIO PESQUISA & SAUDE BUCAL-APESB
PI JOAO PESSOA
PA AGENCIA CIDADE UNIV, UNIV FEDERAL PARAIBA, CAMPUS I, JOAO PESSOA, PB
   58051-970, BRAZIL
SN 1519-0501
EI 1983-4632
J9 PESQUI BRAS ODONTOPE
JI Pesqui. Bras. Odontopediatria Clin. Integr.
PY 2024
VL 24
AR e220170
DI 10.1590/pboci.2024.053
PG 12
WC Dentistry, Oral Surgery & Medicine
WE Emerging Sources Citation Index (ESCI)
SC Dentistry, Oral Surgery & Medicine
GA PR8K4
UT WOS:001215899400001
DA 2025-06-11
ER

PT J
AU Argano, C
   Mirarchi, L
   Amodeo, S
   Orlando, V
   Torres, A
   Corrao, S
AF Argano, Christiano
   Mirarchi, Luigi
   Amodeo, Simona
   Orlando, Valentina
   Torres, Alessandra
   Corrao, Salvatore
TI The Role of Vitamin D and Its Molecular Bases in Insulin Resistance,
   Diabetes, Metabolic Syndrome, and Cardiovascular Disease: State of the
   Art
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE vitamin D; insulin resistance; metabolic syndrome; type 1 and 2
   diabetes; gestational diabetes; cardiovascular diseases and metabolism
ID RENIN-ANGIOTENSIN SYSTEM; 25-HYDROXYVITAMIN D LEVELS; BETA-CELL
   FUNCTION; D DEFICIENCY; D SUPPLEMENTATION; OXIDATIVE STRESS;
   1,25-DIHYDROXYVITAMIN D-3; GLYCEMIC CONTROL; BLOOD-PRESSURE; D-RECEPTOR
AB In the last decade, an increasing awareness was directed to the role of Vitamin D in non-skeletal and preventive roles for chronic diseases. Vitamin D is an essential hormone in regulating calcium/phosphorous balance and in the pathogenesis of inflammation, insulin resistance, and obesity. The main forms of vitamin D, Cholecalciferol (Vitamin D3) and Ergocalciferol (Vitamin D2) are converted into the active form (1,25-dihydroxyvitamin D) thanks to two hydroxylations in the liver, kidney, pancreas, and immune cells. Some anti-inflammatory cytokines are produced at higher levels by vitamin D, while some pro-inflammatory cytokines are released at lower levels. Toll-Like Receptor (TLR) expression is increased, and a pro-inflammatory state is also linked to low levels of vitamin D. Regardless of how it affects inflammation, various pathways suggest that vitamin D directly improves insulin sensitivity and secretion. The level of vitamin D in the body may change the ratio of pro- to anti-inflammatory cytokines, which would impact insulin action, lipid metabolism, and the development and function of adipose tissue. Many studies have demonstrated an inverse relationship between vitamin D concentrations and pro-inflammatory markers, insulin resistance, glucose intolerance, metabolic syndrome, obesity, and cardiovascular disease. It is interesting to note that several long-term studies also revealed an inverse correlation between vitamin D levels and the occurrence of diabetes mellitus. Vitamin D supplementation in people has controversial effects. While some studies demonstrated improvements in insulin sensitivity, glucose, and lipid metabolism, others revealed no significant effect on glycemic homeostasis and inflammation. This review aims to provide insight into the molecular basis of the relationship between vitamin D, insulin resistance, metabolic syndrome, type 1 and 2 diabetes, gestational diabetes, and cardiovascular diseases.
C1 [Argano, Christiano; Mirarchi, Luigi; Amodeo, Simona; Orlando, Valentina; Torres, Alessandra; Corrao, Salvatore] Natl Relevance & High Specializat Hosp Trust ARNAS, Dept Internal Med, I-90127 Palermo, Italy.
   [Corrao, Salvatore] Univ Palermo, Dept Hlth Promot Sci, Internal Med & Med Specialties, Maternal & Infant Care,PROMISE, I-90127 Palermo, Italy.
C3 University of Palermo
RP Argano, C (corresponding author), Natl Relevance & High Specializat Hosp Trust ARNAS, Dept Internal Med, I-90127 Palermo, Italy.
EM christiano.argano@arnascivico.it; luigi.mirarchi@arnascivico.it;
   simona.amodeo@arnascivico.it; valentina.orlando03@community.unipa.it;
   alessandra.torres1993@gmail.com; salvatore.corrao@unipa.it
RI Corrao, Salvatore/AAQ-5768-2020; Corrao, Salvatore/K-3504-2018
OI Corrao, Salvatore/0000-0001-5621-1374; Argano,
   Christiano/0000-0003-2662-8931
CR Adams JS, 2014, J STEROID BIOCHEM, V144, P22, DOI 10.1016/j.jsbmb.2013.12.009
   Afzal S, 2013, CLIN CHEM, V59, P381, DOI 10.1373/clinchem.2012.193003
   Agueero-Domenech N, 2022, NUTRIENTS, V14, DOI 10.3390/nu14010102
   Akbari M, 2017, HORM METAB RES, V49, P647, DOI 10.1055/s-0043-115225
   Al-Shoumer KAS, 2015, WORLD J DIABETES, V6, P1057, DOI 10.4239/wjd.v6.i8.1057
   ALkharashi NA, 2019, SAUDI MED J, V40, P1290, DOI 10.15537/smj.2019.12.24643
   Altieri B, 2017, CRIT REV FOOD SCI, V57, P3472, DOI 10.1080/10408398.2015.1136922
   Alvarez JA, 2010, INT J ENDOCRINOL, V2010, DOI 10.1155/2010/351385
   Andersson-Hall U, 2018, J DIABETES RES, V2018, DOI 10.1155/2018/4207067
   Chagas CEA, 2012, NUTRIENTS, V4, P52, DOI 10.3390/nu4010052
   [Anonymous], 2021, DIABETES RES CLIN PR, V181, DOI 10.1016/j.diabres.2021.109133
   [Anonymous], 2015, DIABETES CARE, V38, pS8, DOI 10.2337/dc15-S005
   [Anonymous], Nutrition Therapy in Gestational Diabetes Mellitus: Time to Move Forward | Diabetes Care
   [Anonymous], Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2022 | Diabetes Care
   [Anonymous], LANCET, V352, P837, DOI DOI 10.1016/S0140-6736(98)07019-6
   Argano C, 2023, PHARMACEUTICALS-BASE, V16, DOI 10.3390/ph16010130
   Argano C, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23052873
   Argano C, 2022, HEALTHCARE-BASEL, V10, DOI 10.3390/healthcare10010086
   Asbaghi O, 2019, HORM METAB RES, V51, P288, DOI 10.1055/a-0887-0205
   Assy MH, 2021, EGYPT J NEUROL PSYCH, V57, DOI 10.1186/s41983-021-00370-9
   Ataie-Jafari A, 2013, CLIN NUTR, V32, P911, DOI 10.1016/j.clnu.2013.01.012
   Bajaj Sarita, 2014, Indian J Endocrinol Metab, V18, P537, DOI 10.4103/2230-8210.137512
   Barbarawi M, 2019, JAMA CARDIOL, V4, P765, DOI 10.1001/jamacardio.2019.1870
   BARON AD, 1988, AM J PHYSIOL, V255, pE769, DOI 10.1152/ajpendo.1988.255.6.E769
   Barragan M, 2015, NUTRIENTS, V7, P8127, DOI 10.3390/nu7095383
   Battault S, 2013, EUR J NUTR, V52, P429, DOI 10.1007/s00394-012-0430-5
   Bener A, 2009, ACTA DIABETOL, V46, P183, DOI 10.1007/s00592-008-0071-6
   Berridge MJ, 2017, BIOCHEM J, V474, P1321, DOI 10.1042/BCJ20170042
   Bikle DD, 2014, CHEM BIOL, V21, P319, DOI 10.1016/j.chembiol.2013.12.016
   Blaak EE, 2012, OBES REV, V13, P923, DOI 10.1111/j.1467-789X.2012.01011.x
   Bland R, 2004, J STEROID BIOCHEM, V89-90, P121, DOI 10.1016/j.jsbmb.2004.03.115
   Borissova AM, 2003, INT J CLIN PRACT, V57, P258
   Bouillon R, 2008, ENDOCR REV, V29, P726, DOI 10.1210/er.2008-0004
   Bovolini A, 2021, INT J SPORTS MED, V42, P199, DOI 10.1055/a-1263-0898
   Brandenburg VM, 2012, ATHEROSCLEROSIS, V225, P253, DOI 10.1016/j.atherosclerosis.2012.08.005
   CADE C, 1986, ENDOCRINOLOGY, V119, P84, DOI 10.1210/endo-119-1-84
   Casteels KM, 1998, ENDOCRINOLOGY, V139, P95, DOI 10.1210/en.139.1.95
   Castro-Barquero S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12102983
   Cernea S, 2010, DIABETES-METAB RES, V26, P602, DOI 10.1002/dmrr.1138
   Charoenngam Nipith, 2019, J Clin Orthop Trauma, V10, P1082, DOI 10.1016/j.jcot.2019.07.004
   Chatzakis C, 2021, NUTRIENTS, V13, DOI 10.3390/nu13072284
   Chen XQ, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.971720
   Chen Y, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2017-016404
   Cigolini M, 2006, DIABETES CARE, V29, P722, DOI 10.2337/diacare.29.03.06.dc05-2148
   Clarke NMP, 2012, CURR OPIN PEDIATR, V24, P46, DOI 10.1097/MOP.0b013e32834ec8eb
   Contreras-Bolivar V, 2021, NUTRIENTS, V13, DOI 10.3390/nu13103491
   Corrao S, 2006, J AM MED INFORM ASSN, V13, P485, DOI 10.1197/jamia.M2084
   Corrao S, 2021, NUTRIENTS, V13, DOI 10.3390/nu13041261
   Corrao S, 2012, INTERN EMERG MED, V7, P283, DOI 10.1007/s11739-012-0773-1
   Dahlquist G, 1999, DIABETOLOGIA, V42, P51, DOI 10.1007/s001250051112
   Danescu LG, 2009, ENDOCRINE, V35, P11, DOI 10.1007/s12020-008-9115-5
   Dankers W, 2017, FRONT IMMUNOL, V7, DOI 10.3389/fimmu.2016.00697
   Dattola A, 2020, CURR NUTR REP, V9, P226, DOI 10.1007/s13668-020-00322-4
   de Boer IH, 2009, J AM SOC NEPHROL, V20, P1805, DOI 10.1681/ASN.2008111157
   de Paula TP, 2017, SCI REP-UK, V7, DOI 10.1038/srep40751
   DEFRONZO RA, 1981, DIABETES, V30, P1000, DOI 10.2337/diab.30.12.1000
   Di Cesar DJ, 2006, DIABETES CARE, V29, P174, DOI 10.2337/diacare.29.1.174
   Ding YH, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000006445
   Dong JY, 2013, NUTRIENTS, V5, P3551, DOI 10.3390/nu5093551
   Earthman CP, 2012, INT J OBESITY, V36, P387, DOI 10.1038/ijo.2011.119
   FADDA GZ, 1990, AM J PHYSIOL, V258, pE975, DOI 10.1152/ajpendo.1990.258.6.E975
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Faraji S, 2020, J OBES METAB SYNDR, V29, P270, DOI 10.7570/jomes20003
   Ferreira PP, 2020, CLIMACTERIC, V23, P24, DOI [10.1007/s10111-019-00540-z, 10.1080/13697137.2019.1611761]
   Flaim C, 2017, J NUTR BIOCHEM, V50, P95, DOI 10.1016/j.jnutbio.2017.05.003
   Fronczak CM, 2003, DIABETES CARE, V26, P3237, DOI 10.2337/diacare.26.12.3237
   Fulcher J, 2015, LANCET, V385, P1397, DOI 10.1016/S0140-6736(14)61368-4
   Gagnon C, 2011, DIABETES CARE, V34, P1133, DOI 10.2337/dc10-2167
   Ganji V, 2020, BIOFACTORS, V46, P180, DOI 10.1002/biof.1572
   Gregoriou Elina, 2017, Rev Diabet Stud, V14, P260, DOI 10.1900/RDS.2017.14.260
   Grissa O, 2007, TRANSL RES, V150, P164, DOI 10.1016/j.trsl.2007.03.007
   Groof Z, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/9136250
   Grossman E, 2013, DIABETES CARE, V36, pS307, DOI 10.2337/dcS13-2039
   Gysemans CA, 2005, ENDOCRINOLOGY, V146, P1956, DOI 10.1210/en.2004-1322
   Haidari F, 2016, IRAN J MED SCI, V41, P367
   Hajhashemy Z, 2021, OBES REV, V22, DOI 10.1111/obr.13223
   Han FF, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0477-7
   Haussler MR, 1997, J ENDOCRINOL, V154, pS57
   Heshmati J, 2018, J FUNCT FOODS, V46, P66, DOI 10.1016/j.jff.2018.04.049
   Hewison M, 2012, CLIN ENDOCRINOL, V76, P315, DOI 10.1111/j.1365-2265.2011.04261.x
   Hii CS, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030135
   Hojs R, 2016, NEPHRON, V133, P159, DOI 10.1159/000447434
   Holick MF, 2007, NEW ENGL J MED, V357, P266, DOI 10.1056/NEJMra070553
   Hou YL, 2021, EUR J CLIN NUTR, V75, P1010, DOI 10.1038/s41430-020-00813-1
   Hu ZW, 2019, MEDICINE, V98, DOI [10.1097/MD.0000000000014970, 10.1097/md.0000000000014970]
   Huang SZ, 2021, ANN PALLIAT MED, V10, P5652, DOI 10.21037/apm-21-1018
   Huber A, 2008, ENDOCR REV, V29, P697, DOI 10.1210/er.2008-0015
   Hussin AM, 2017, EUR J NUTR, V56, P1095, DOI 10.1007/s00394-016-1159-3
   Hyppönen E, 2001, LANCET, V358, P1500, DOI 10.1016/S0140-6736(01)06580-1
   Ismail NA, 2021, J OBSTET GYNAECOL, V41, P899, DOI 10.1080/01443615.2020.1820462
   Jacobson TA, 2015, J CLIN LIPIDOL, V9, pS1, DOI 10.1016/j.jacl.2015.09.002
   Jafari T, 2016, CLIN NUTR, V35, P1259, DOI 10.1016/j.clnu.2016.03.001
   Jahanjoo F, 2018, ANN NUTR METAB, V73, P145, DOI 10.1159/000491643
   Jain SK, 2013, BIOCHEM BIOPH RES CO, V437, P7, DOI 10.1016/j.bbrc.2013.06.004
   Jefferson GE, 2017, J PHYSIOL BIOCHEM, V73, P613, DOI 10.1007/s13105-017-0595-8
   Jenum AK, 2012, EUR J ENDOCRINOL, V166, P317, DOI 10.1530/EJE-11-0866
   Jiang X, 2019, BONE, V126, P59, DOI 10.1016/j.bone.2018.10.006
   Jin SX, 2020, J DIABETES RES, V2020, DOI 10.1155/2020/6062478
   Johannesson B, 2015, EMBO J, V34, P841, DOI 10.15252/embj.201490685
   Jorde R, 2010, HYPERTENSION, V55, P792, DOI 10.1161/HYPERTENSIONAHA.109.143990
   Kabadi SM, 2012, DIABETES CARE, V35, P2048, DOI 10.2337/dc12-0235
   Karadeniz Y, 2021, MEDICINA-LITHUANIA, V57, DOI 10.3390/medicina57121297
   Karkeni E, 2018, EPIGENETICS-US, V13, P156, DOI 10.1080/15592294.2016.1276681
   Khademi Z, 2022, BMC ENDOCR DISORD, V22, DOI 10.1186/s12902-022-01141-0
   Khambule L, 2019, ADV EXP MED BIOL, V1134, P217, DOI 10.1007/978-3-030-12668-1_12
   Klopot A, 2007, J CELL BIOCHEM, V100, P617, DOI 10.1002/jcb.21087
   Kron-Rodrigues MR, 2021, REV BRAS GINECOL OBS, V43, P699, DOI 10.1055/s-0041-1734000
   Krul-Poel YHM, 2017, EUR J ENDOCRINOL, V176, pR1, DOI [10.1530/eje-16-0391, 10.1530/EJE-16-0391]
   Larrick BM, 2018, NUTR RES, V58, P72, DOI 10.1016/j.nutres.2018.07.004
   Lee CJ, 2017, J DIABETES COMPLICAT, V31, P1115, DOI 10.1016/j.jdiacomp.2017.04.019
   Li XY, 2018, NUTRIENTS, V10, DOI 10.3390/nu10030375
   Li YC, 2002, J CLIN INVEST, V110, P229, DOI [10.1172/JCI200215219, 10.1172/JCI0215219]
   Licata G, 2006, PANMINERVA MED, V48, P77
   Littorin B, 2006, DIABETOLOGIA, V49, P2847, DOI 10.1007/s00125-006-0426-x
   López-Tinoco C, 2013, ACTA DIABETOL, V50, P201, DOI 10.1007/s00592-011-0264-2
   Lotfy M, 2017, CURR DIABETES REV, V13, P3, DOI 10.2174/1573399812666151016101622
   Lu M, 2016, ARCH GYNECOL OBSTET, V293, P959, DOI 10.1007/s00404-016-4010-4
   Luong KVQ, 2005, DIABETES-METAB RES, V21, P338, DOI 10.1002/dmrr.557
   Maddaloni E, 2018, FRONT HORM RES, V50, P161, DOI 10.1159/000486083
   Maestro B, 2002, CELL BIOCHEM FUNCT, V20, P227, DOI 10.1002/cbf.951
   Maestro B, 2000, ENDOCR J, V47, P383, DOI 10.1507/endocrj.47.383
   Maged AM, 2016, J MATERN-FETAL NEO M, V29, P4049, DOI 10.3109/14767058.2016.1154526
   Magnusdottir KS, 2021, FOOD NUTR RES, V65, DOI 10.29219/fnr.v65.5574
   Mahmood SF, 2016, INT J VITAM NUTR RES, V86, P121, DOI 10.1024/0300-9831/a000426
   Mancuso P, 2008, J CARDIOVASC PHARM, V51, P559, DOI 10.1097/FJC.0b013e3181761906
   Mannarino E, 2008, CLIN CASES MINER BON, V5, P57
   Mathieu C, 2005, TRENDS ENDOCRIN MET, V16, P261, DOI 10.1016/j.tem.2005.06.004
   MATHIEU C, 1994, DIABETOLOGIA, V37, P552, DOI 10.1007/BF00403372
   McGreevy C, 2011, ANN INTERN MED, V155, P820, DOI 10.7326/0003-4819-155-12-201112200-00004
   McMullan CJ, 2017, J HYPERTENS, V35, P822, DOI 10.1097/HJH.0000000000001220
   Melguizo-Rodríguez L, 2021, NUTRIENTS, V13, DOI 10.3390/nu13030830
   Milajerdi A, 2021, CLIN NUTR, V40, P2576, DOI 10.1016/j.clnu.2021.03.037
   Milajerdi A, 2018, INT J VITAM NUTR RES, V88, P166, DOI 10.1024/0300-9831/a000505
   Mirhosseini N, 2018, J ENDOCR SOC, V2, P687, DOI 10.1210/js.2017-00472
   Mitri J, 2011, EUR J CLIN NUTR, V65, P1005, DOI 10.1038/ejcn.2011.118
   Mitri J, 2011, AM J CLIN NUTR, V94, P486, DOI 10.3945/ajcn.111.011684
   Mo MJ, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124220
   Muoio DM, 2008, NAT REV MOL CELL BIO, V9, P193, DOI 10.1038/nrm2327
   Najjar L, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124260
   Namazi N, 2018, CLIN NUTR, V37, P419, DOI 10.1016/j.clnu.2017.06.002
   Nascimento BF, 2022, J PEDIATR ENDOCR MET, V35, P973, DOI 10.1515/jpem-2022-0044
   Nazarian S, 2011, TRANSL RES, V158, P276, DOI 10.1016/j.trsl.2011.05.002
   Noctor E, 2015, ACTA DIABETOL, V52, P153, DOI 10.1007/s00592-014-0621-z
   Norris JM, 2020, LANCET DIABETES ENDO, V8, P226, DOI 10.1016/S2213-8587(19)30412-7
   Norris JM, 2018, DIABETES, V67, P146, DOI 10.2337/db17-0802
   Omar DF, 2018, CAN J DIABETES, V42, P588, DOI 10.1016/j.jcjd.2018.02.012
   Ostadmohammadi V, 2019, CURR PHARM DESIGN, V25, P201, DOI 10.2174/1381612825666190308152943
   Pan GT, 2016, J NUTR SCI VITAMINOL, V62, P213, DOI 10.3177/jnsv.62.213
   Park S, 2016, J NUTR BIOCHEM, V27, P257, DOI 10.1016/j.jnutbio.2015.09.013
   Paschou SA, 2018, ENDOCR CONNECT, V7, pR38, DOI 10.1530/EC-17-0347
   Penna G, 2000, J IMMUNOL, V164, P2405, DOI 10.4049/jimmunol.164.5.2405
   Peuchant E, 2004, CLIN BIOCHEM, V37, P293, DOI 10.1016/j.clinbiochem.2003.12.005
   Pienkowska A, 2023, NUTRIENTS, V15, DOI 10.3390/nu15040983
   Pilz S, 2009, NAT REV CARDIOL, V6, P621, DOI 10.1038/nrcardio.2009.135
   Pittas AG, 2007, J CLIN ENDOCR METAB, V92, P2017, DOI 10.1210/jc.2007-0298
   Pittas AG, 2007, DIABETES CARE, V30, P980, DOI 10.2337/dc06-1994
   Pramono A, 2019, DIABETES-METAB RES, V35, DOI 10.1002/dmrr.3146
   Qi KJ, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.1033026
   Rafiq S, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124358
   REUSCH JEB, 1991, ENDOCRINOLOGY, V129, P3269, DOI 10.1210/endo-129-6-3269
   Richart T, 2007, AM J HYPERTENS, V20, P1007, DOI 10.1016/j.amjhyper.2007.03.017
   Rooney MR, 2023, DIABETES CARE, V46, P1388, DOI 10.2337/dc22-2376
   Rosen CJ, 2012, ENDOCR REV, V33, P456, DOI 10.1210/er.2012-1000
   ROSS A, 2011, DIETARY REFERENCE IN
   Ryan ZC, 2016, J BIOL CHEM, V291, P1514, DOI 10.1074/jbc.M115.684399
   Saffian SM, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.1050745
   Saha S, 2021, J TURK-GER GYNECOL A, V22, P217, DOI 10.4274/jtgga.galenos.2021.2020.0197
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Scragg R, 2004, DIABETES CARE, V27, P2813, DOI 10.2337/diacare.27.12.2813
   Selvaraj P, 2015, CAN J PHYSIOL PHARM, V93, P377, DOI 10.1139/cjpp-2014-0386
   Sepidarkish M, 2019, PHARMACOL RES, V139, P141, DOI 10.1016/j.phrs.2018.11.011
   Shang M, 2015, DIABETES RES CLIN PR, V109, P404, DOI 10.1016/j.diabres.2015.05.010
   Sharma S, 2017, J CLIN DIAGN RES, V11, pSC15, DOI 10.7860/JCDR/2017/27321.10645
   Shehab D, 2012, DIABETIC MED, V29, P43, DOI 10.1111/j.1464-5491.2011.03510.x
   Sherman MH, 2014, CELL, V159, P80, DOI 10.1016/j.cell.2014.08.007
   Shi H, 2001, FASEB J, V15, P2751, DOI 10.1096/fj.01-0584fje
   Sies H, 2007, J NUTR, V137, P1493, DOI 10.1093/jn/137.6.1493
   Sindhughosa DA, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-11950-x
   Siti HN, 2015, VASC PHARMACOL, V71, P40, DOI 10.1016/j.vph.2015.03.005
   Slominski AT, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-10202-7
   Soheilykhah S, 2010, NUTR CLIN PRACT, V25, P524, DOI 10.1177/0884533610379851
   Soltesz G, 2007, PEDIATR DIABETES, V8, P6, DOI 10.1111/j.1399-5448.2007.00280.x
   Song YQ, 2013, DIABETES CARE, V36, P1422, DOI 10.2337/dc12-0962
   STORM TL, 1984, METAB BONE DIS RELAT, V5, P107, DOI 10.1016/0221-8747(83)90010-3
   Szymczak-Pajor I, 2019, NUTRIENTS, V11, DOI 10.3390/nu11040794
   Taheri E, 2012, J DIABETES METAB DIS, V11, DOI 10.1186/2251-6581-11-16
   Takiishi T, 2010, ENDOCRIN METAB CLIN, V39, P419, DOI 10.1016/j.ecl.2010.02.013
   Targher G, 2007, NUTR METAB CARDIOVAS, V17, P517, DOI 10.1016/j.numecd.2006.04.002
   Teixeira JS, 2018, NUTR HOSP, V35, P847, DOI 10.20960/nh.1657
   Teleni L, 2013, NUTR REV, V71, P611, DOI 10.1111/nure.12047
   Tomaschitz A, 2010, CLIN CHIM ACTA, V411, P1354, DOI 10.1016/j.cca.2010.05.037
   Umar M, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19061618
   Vaidya A, 2012, METABOLISM, V61, P759, DOI 10.1016/j.metabol.2011.12.009
   Verma A, 2002, J CLIN ENDOCR METAB, V87, P3227, DOI 10.1210/jc.87.7.3227
   Vimaleswaran KS, 2014, LANCET DIABETES ENDO, V2, P719, DOI 10.1016/S2213-8587(14)70113-5
   von Websky K, 2018, J STEROID BIOCHEM, V180, P51, DOI 10.1016/j.jsbmb.2017.11.008
   Wang HD, 2016, LANCET, V388, P1459, DOI 10.1016/S0140-6736(16)31012-1
   Wang H, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-42
   Wang LL, 2020, ARCH MED SCI, V16, P742, DOI 10.5114/aoms.2020.94433
   Wang Meng Meng, 2021, Zhongguo Yi Xue Ke Xue Yuan Xue Bao, V43, P82, DOI 10.3881/j.issn.1000-503X.12940
   Wang MM, 2021, CLIN NUTR, V40, P3148, DOI 10.1016/j.clnu.2020.12.016
   Wang NJ, 2020, EUR J NUTR, V59, P1379, DOI 10.1007/s00394-019-01990-x
   Wang SJ, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000020148
   Wang WC, 2019, INT J CLIN EXP PATHO, V12, P1859
   Wei Z, 2018, CELL, V173, P1135, DOI 10.1016/j.cell.2018.04.013
   Wimalawansa SJ, 2018, J STEROID BIOCHEM, V175, P60, DOI 10.1016/j.jsbmb.2016.09.016
   Wolf M, 2004, DIABETES CARE, V27, P21, DOI 10.2337/diacare.27.1.21
   Wong MSK, 2008, AM J PHYSIOL-HEART C, V295, pH289, DOI 10.1152/ajpheart.00116.2008
   Wu CF, 2023, INT J CLIN PRACT, V2023, DOI 10.1155/2023/1907222
   Wu ZK, 2016, SCAND CARDIOVASC J, V50, P9, DOI 10.3109/14017431.2015.1103893
   Xu YY, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000023672
   Yang CY, 2013, CLIN REV ALLERG IMMU, V45, P217, DOI 10.1007/s12016-013-8361-3
   Yang C, 2021, BMC PREGNANCY CHILDB, V21, DOI 10.1186/s12884-021-03889-0
   Yu J, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms232214434
   Zakharova I, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00103
   Zehnder D, 2002, J AM SOC NEPHROL, V13, DOI 10.1681/ASN.V133621
   Zeitz U, 2003, FASEB J, V17, P509, DOI 10.1096/fj.02-0424fje
   Zella JB, 2003, ARCH BIOCHEM BIOPHYS, V417, P77, DOI 10.1016/S0003-9861(03)00338-2
   Zhang XL, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/157834
   Zhang Y, 2018, BJOG-INT J OBSTET GY, V125, P784, DOI 10.1111/1471-0528.15060
   Zhao JY, 2014, CHINESE MED J-PEKING, V127, P2837, DOI 10.3760/cma.j.issn.0366-6999.20140792
   Zheng JS, 2020, PLOS MED, V17, DOI 10.1371/journal.pmed.1003394
   Zheng Y, 2018, NAT REV ENDOCRINOL, V14, P88, DOI 10.1038/nrendo.2017.151
   Zhou CL, 2008, KIDNEY INT, V74, P170, DOI 10.1038/ki.2008.101
   Zhu W, 2018, DIABETES METAB SYND, V12, P727, DOI 10.1016/j.dsx.2018.04.010
   Zhu YH, 2018, BIOMOLECULES, V8, DOI 10.3390/biom8030080
NR 226
TC 55
Z9 58
U1 4
U2 15
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2023
VL 24
IS 20
AR 15485
DI 10.3390/ijms242015485
PG 26
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA X0EN7
UT WOS:001095271600001
PM 37895163
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Meyer, JA
AF Meyer, Jonathan M.
TI Strategies for the long-term treatment of schizophrenia: Real-world
   lessons from the CATIE trial
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article; Proceedings Paper
CT Teleconference on Evaluating the Evidence - Clinical Antipsychotic
   Trials of Intervention Effectiveness (CATIE)
CY MAY 10, 2006
CL ELECTR NETWORK
ID CLINICAL ANTIPSYCHOTIC TRIALS; METABOLIC SYNDROME; SUBSTANCE-ABUSE;
   HEPATITIS-B; DRUG-ABUSE; PREVALENCE; PEOPLE; HEALTH; REHABILITATION;
   RISK
AB Patients with schizophrenia have a chronic illness necessitating a biopsychosocial model of care that addresses the multiple dimensions of the disease, including coordinated primary care. Current research, including the lessons learned from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study, shows that in addition to education, adherence, and minimizing adverse effects of psychopharmacologic agents, multimodal long-term treatment strategies are needed to address medical comorbidities, substance abuse, and both cognitive and social deficits. Health care professionals have the responsibility to monitor and help prevent adverse medical outcomes related to treatment with antipsychotics, in light of evidence that patients with schizophrenia are at risk for metabolic disorders and are undertreated for highly prevalent cardiovascular risk factors. These medical problems are particularly challenging in this population due to the chronicity of symptoms, cognitive limitations, social and financial challenges, and compliance issues with recommended medication treatment and therapeutic lifestyle changes. Mental health providers in the United States are now studying models that support the integration of psychiatric and nonpsychiatric medical treatment to address the complexity of multimodal schizophrenia care.
C1 Univ Calif San Diego, Dept Psychiat, San Diego, CA 92161 USA.
C3 University of California System; University of California San Diego
RP Meyer, JA (corresponding author), Univ Calif San Diego, Dept Psychiat, 3350 La Jolla Village Dr 116A, San Diego, CA 92161 USA.
EM jmmeyer@ucsd.edu
CR ADLER LE, 1993, AM J PSYCHIAT, V150, P1856
   [Anonymous], 2004, J CLIN PSYCHIAT, V65, P267
   Bellack AS, 2006, ARCH GEN PSYCHIAT, V63, P426, DOI 10.1001/archpsyc.63.4.426
   Bellack AS, 2004, PSYCHIATR REHABIL J, V27, P375, DOI 10.2975/27.2004.375.391
   Dickey B, 2002, PSYCHIATR SERV, V53, P861, DOI 10.1176/appi.ps.53.7.861
   Dixon L, 1999, J NERV MENT DIS, V187, P496, DOI 10.1097/00005053-199908000-00006
   Dolder CR, 2003, J CLIN PSYCHOPHARM, V23, P389, DOI 10.1097/01.jcp.0000085413.08426.41
   DPP Res Grp, 2002, DIABETES CARE, V25, P2165
   Drake RE, 1998, SCHIZOPHRENIA BULL, V24, P589, DOI 10.1093/oxfordjournals.schbul.a033351
   Evins A E, 2001, Nicotine Tob Res, V3, P397, DOI 10.1080/14622200110073920
   George TP, 2002, BIOL PSYCHIAT, V52, P53, DOI 10.1016/S0006-3223(02)01339-2
   Goff DC, 2005, SCHIZOPHR RES, V80, P45, DOI 10.1016/j.schres.2005.08.010
   Green MF, 2004, SCHIZOPHR RES, V72, P41, DOI 10.1016/j.schres.2004.09.009
   Harvey PD, 2000, SCHIZOPHR RES, V43, P3, DOI 10.1016/S0920-9964(99)00182-6
   Hennekens CH, 2005, AM HEART J, V150, P1115, DOI 10.1016/j.ahj.2005.02.007
   Jones DR, 2004, PSYCHIAT SERV, V55, P1250, DOI 10.1176/appi.ps.55.11.1250
   Kavanagh D.J., 2000, Acta Psychiatrica Scandinavaca, V102, P404, DOI [10.1016/S0920-9964(03)00130-0, DOI 10.1016/S0920-9964(03)00130-0]
   Kavanagh DJ, 2002, DRUGS, V62, P743, DOI 10.2165/00003495-200262050-00003
   Krystal JH, 1999, SCHIZOPHR RES, V35, pS35, DOI 10.1016/S0920-9964(98)00162-5
   Kumari V, 2005, NEUROSCI BIOBEHAV R, V29, P1021, DOI 10.1016/j.neubiorev.2005.02.006
   Levin ED, 1996, NEUROPSYCHOPHARMACOL, V15, P429, DOI 10.1016/S0893-133X(96)00018-8
   Lieberman JA, 2005, NEW ENGL J MED, V353, P1209, DOI 10.1056/NEJMoa051688
   Loh Catherine, 2006, Ann Clin Psychiatry, V18, P23, DOI 10.1080/10401230500464646
   Magliano Lorenza, 2005, World Psychiatry, V4, P45
   Marder SR, 2004, AM J PSYCHIAT, V161, P1334, DOI 10.1176/appi.ajp.161.8.1334
   McEvoy JP, 2005, SCHIZOPHR RES, V80, P19, DOI 10.1016/j.schres.2005.07.014
   Meyer JM, 2005, CLIN THER, V27, P1930, DOI 10.1016/j.clinthera.2005.12.005
   Meyer JM, 2003, J CLIN PSYCHIAT, V64, P540, DOI 10.4088/JCP.v64n0507
   Meyer JM, 2005, SCHIZOPHR RES, V80, P9, DOI 10.1016/j.schres.2005.07.015
   MEYER JM, 2003, MED ILLNESS SCHIZOPH, P59
   Miller W, 1991, Motivational interviewing: Helping people change
   Nasrallah HA, 2006, SCHIZOPHR RES, V86, P15, DOI 10.1016/j.schres.2006.06.026
   Nasrallah Henry A, 2004, J Clin Psychopharmacol, V24, pS7, DOI 10.1097/01.jcp.0000142282.62336.e9
   *NAT CHOL ED PROG, NIH PUBL
   Newcomer JW, 2005, CNS DRUGS, V19, P1
   Ösby U, 2000, SCHIZOPHR RES, V45, P21, DOI 10.1016/S0920-9964(99)00191-7
   Pharoah F, 2006, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD000088.pub2, 10.1002/14651858.CD000088.pub3]
   REGIER DA, 1990, JAMA-J AM MED ASSOC, V264, P2511
   Remington G, 2005, SCHIZOPHR RES, V76, P267, DOI 10.1016/j.schres.2005.01.009
   Rosenberg SD, 2001, AM J PUBLIC HEALTH, V91, P31, DOI 10.2105/AJPH.91.1.31
   Saari KM, 2005, J CLIN PSYCHIAT, V66, P559, DOI 10.4088/JCP.v66n0503
   Silverstein SM, 2004, SCHIZOPHRENIA BULL, V30, P679, DOI 10.1093/oxfordjournals.schbul.a007122
   Straker D, 2005, AM J PSYCHIAT, V162, P1217, DOI 10.1176/appi.ajp.162.6.1217
   Stroup TS, 2006, AM J PSYCHIAT, V163, P611, DOI 10.1176/appi.ajp.163.4.611
   Twamley EW, 2005, J NERV MENT DIS, V193, P596, DOI 10.1097/01.nmd.0000177789.53840.e3
   Twamley EW, 2003, J NERV MENT DIS, V191, P515, DOI 10.1097/01.nmd.0000082213.42509.69
   Weiden PJ, 2003, J CLIN PSYCHOPHARM, V23, P595, DOI 10.1097/01.jcp.0000095347.32154.08
   Weiden PJ, 2004, SCHIZOPHR RES, V66, P51, DOI 10.1016/S0920-9964(02)00498-X
   WEIDEN PJ, 2004, 157 ANN M AM PSYCH A
NR 49
TC 18
Z9 21
U1 0
U2 17
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PY 2007
VL 68
SU 1
BP 28
EP 33
PG 6
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S); Conference Proceedings Citation Index - Social Science &amp; Humanities (CPCI-SSH)
SC Psychology; Psychiatry
GA 134HR
UT WOS:000244074600005
PM 17286525
DA 2025-06-11
ER

PT J
AU Oh, SS
   Jang, JE
   Lee, DW
   Park, EC
   Jang, SI
AF Oh, Sarah Soyeon
   Jang, Ji-Eun
   Lee, Doo-Woong
   Park, Eun-Cheol
   Jang, Sung-In
TI Cigarette type or smoking history: Which has a greater impact on the
   metabolic syndrome and its components?
SO SCIENTIFIC REPORTS
LA English
DT Article
ID BLOOD-PRESSURE; RISK; ASSOCIATION; DEPRESSION; ADULTS
AB Few studies have researched the gender-specific effects of electronic nicotine delivery systems on the metabolic syndrome (MetS) and/or its risk factors (central obesity, raised triglycerides, decreased HDL cholesterol, raised blood pressure, raised fasting plasma glucose). Thus, this study investigated the association between smoking behavior (cigarette type, smoking history) and MetS in a nationally representative sample of Korean men and women. Our study employed data for 5,462 cases of MetS and 12,194 controls from the Korea National Health and Nutritional Examination Survey (KNHANES) for the years 2014 to 2017. Logistic regression analysis was employed to determine the association between type of cigarette (non-smoker, ex-smoker, and current smoker-conventional only, current smoker-conventional and electronic) and the prevalence of metabolic syndrome and its risk factors. Smoking history was clinically quantified by pack-year. No association between cigarette type and MetS was found for men. For women, relative to non-smokers, smokers of conventional cigarettes (OR 1.80, 95% CI 1.02-3.18) and both conventional and electronic cigarettes (OR 4.02, 95% CI 1.48-10.93) had increased odds of MetS. While there was no association between smoking history and MetS for women, for men, conventional smoking history was associated with MetS for individuals with a smoking history of>25 pack-years (>25 to <= 37.5 OR 1.45, 95% CI 1.04-2.02;>37.5 to <= 50 OR 1.53, 95% CI 1.08-2.18;>50 OR 1.56, 95% CI 1.07-2.27). Sex differences were found in the association between smoking behavior and MetS. Such findings reveal sociodemographic differences that should be considered for interventions regarding conventional and/or e-cigarette users at risk of metabolic complications.
C1 [Oh, Sarah Soyeon; Jang, Ji-Eun; Lee, Doo-Woong; Park, Eun-Cheol; Jang, Sung-In] Yonsei Univ, Coll Med, Inst Hlth Serv Res, Seoul, South Korea.
   [Oh, Sarah Soyeon; Lee, Doo-Woong] Yonsei Univ, Coll Med, Dept Publ Hlth, Grad Sch, Seoul, South Korea.
   [Park, Eun-Cheol; Jang, Sung-In] Yonsei Univ, Coll Med, Dept Prevent Med, Seoul, South Korea.
   [Jang, Ji-Eun] Ajou Univ, Coll Med, Dept Publ Hlth, Grad Sch, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University Health System; Yonsei University; Yonsei University
   Health System; Ajou University
RP Jang, SI (corresponding author), Yonsei Univ, Coll Med, Inst Hlth Serv Res, Seoul, South Korea.; Jang, SI (corresponding author), Yonsei Univ, Coll Med, Dept Prevent Med, Seoul, South Korea.
EM JANGSI@yuhs.ac
RI Park, Eun-Cheol/O-5644-2019; Lee, Doo Woong/IAL-9314-2023
OI Park, Eun-Cheol/0000-0002-2306-5398; Oh, Sarah/0000-0001-5709-2311;
   Jang, Sung-in/0000-0002-0760-2878; LEE, DOO WOONG/0000-0002-8843-2099
FU Yonsei University College of Medicine [6-2018-0174, 6-2017-0157]
FX This study was supported by a faculty research grant of Yonsei
   University College of Medicine (6-2018-0174 and 6-2017-0157).
CR [Anonymous], 2015, ELECT CIGARETTE USE
   Bermudez Valmore, 2018, F1000Res, V7, P565, DOI 10.12688/f1000research.14571.1
   Borderud SP, 2014, CANCER-AM CANCER SOC, V120, P3527, DOI 10.1002/cncr.28811
   Callahan-Lyon P, 2014, TOB CONTROL, V23, P36, DOI 10.1136/tobaccocontrol-2013-051470
   Cheng E, 2019, ACTA DIABETOL, V56, P473, DOI 10.1007/s00592-018-1264-2
   Cho JH, 2011, J ADOLESCENT HEALTH, V49, P542, DOI 10.1016/j.jadohealth.2011.08.001
   Choi DW, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15102260
   El Golli N, 2016, LIFE SCI, V146, P131, DOI 10.1016/j.lfs.2015.12.049
   Farsalinos K, 2016, INTERN EMERG MED, V11, P85, DOI 10.1007/s11739-015-1361-y
   Glover M, 2016, NICOTINE TOB RES, V19, P1536
   Jung SJ, 2015, J AFFECT DISORDERS, V175, P176, DOI 10.1016/j.jad.2014.12.061
   Kim Jee-Youn, 2018, J Phys Ther Sci, V30, P595, DOI 10.1589/jpts.30.595
   Kwon YJ, 2017, J CLIN SLEEP MED, V13, P1097, DOI 10.5664/jcsm.6732
   Lee JA, 2016, INT J PUBLIC HEALTH, V61, P151, DOI 10.1007/s00038-015-0763-y
   Lee K, 2009, KOREA DEV EC ASS, V15, P55, DOI DOI 10.1080/10242694.2014.960247
   Lee S, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-36402-3
   Moheimani RS, 2017, JAMA CARDIOL, V2, P278, DOI 10.1001/jamacardio.2016.5303
   Oh SS, 2018, ALCOHOL, V71, P15, DOI 10.1016/j.alcohol.2018.01.005
   Owczarczyk-Saczonek AB, 2015, POSTEP DERM ALERGOL, V32, P331, DOI 10.5114/pdia.2015.54743
   Ponzoni L, 2015, EUR NEUROPSYCHOPHARM, V25, P1775, DOI 10.1016/j.euroneuro.2015.06.010
   Radaelli G, 2018, EPILEPSY BEHAV, V85, P32, DOI 10.1016/j.yebeh.2018.05.015
   Russo C, 2016, SCI REP-UK, V6, DOI 10.1038/srep18763
   Siemiatycki J, 2014, AM J PUBLIC HEALTH, V104, pE60, DOI 10.2105/AJPH.2014.302040
   Verhaegen A, 2017, OBES REV, V18, P1136, DOI 10.1111/obr.12568
   Vlachopoulos C, 2016, J AM COLL CARDIOL, V67, P2802, DOI 10.1016/j.jacc.2016.03.569
   Wada T, 2007, INTERNAL MED, V46, P1079, DOI 10.2169/internalmedicine.46.0026
   WHO, 2014, GLOBAL STATUS REPORT ON VIOLENCE PREVENTION 2014, P1
   Wills TA, 2015, PEDIATRICS, V135, pE43, DOI 10.1542/peds.2014-0760
   Wilson PW, 2003, CIRCULATION, V107, pE7004
   Yankey BNA, 2016, DIABETES METAB SYND, V10, pS89, DOI 10.1016/j.dsx.2016.03.001
   Yoon SH, 2015, BMC PUBLIC HEALTH, V15, DOI 10.1186/s12889-015-1839-6
NR 31
TC 30
Z9 31
U1 0
U2 1
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 26
PY 2020
VL 10
IS 1
AR 10467
DI 10.1038/s41598-020-67524-2
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA MG3XQ
UT WOS:000545967200064
PM 32591636
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Howell, S
   Yarovova, E
   Khwanda, A
   Rosen, SD
AF Howell, Sandra
   Yarovova, Ekaterina
   Khwanda, Ahmad
   Rosen, Stuart D.
TI Cardiovascular effects of psychotic illnesses and antipsychotic therapy
SO HEART
LA English
DT Review
ID CLOZAPINE-INDUCED MYOCARDITIS; SEVERE MENTAL-ILLNESS; QTC-INTERVAL;
   RISK; SCHIZOPHRENIA; MORTALITY; DEATH; METAANALYSIS; DRUG;
   CARDIOMYOPATHY
AB Mortality from cardiovascular disease is increased in people with mental health disorders in general and schizophrenia in particular. The causes are multifactorial, but it is known that antipsychotic medication can cause cardiac side-effects beyond the traditional coronary risk factors. Schizophrenia itself is a contributor to an increased risk of cardiovascular mortality via cardiac autonomic dysfunction and a higher prevalence of metabolic syndrome, both contributing to a reduced life expectancy. The pro-arrhythmic impact of traditional antipsychotics, especially via the hERG-potassium channel, has been known for several years. Newer antipsychotics have a reduced pro-arrhythmic profile but might contribute to higher cardiac death rates by worsening the metabolic profile. Clozapine-induced cardiomyopathy, which is dose independent, is a further concern and continuous monitoring of these patients is required. Prophylaxis with angiotensin-converting enzyme inhibitors is currently under review. Overall, management of cardiovascular risk within this population group must be multifaceted and nuanced to allow the most effective treatment of serious mental illness to be conducted within acceptable parameters of cardiovascular risk; some practical measures are presented for the clinical cardiologist.
C1 [Howell, Sandra; Yarovova, Ekaterina; Rosen, Stuart D.] London North West Univ Healthcare NHS Trust, Ealing Hosp, Cardiol, London, Middx, England.
   [Yarovova, Ekaterina] Imperial Coll London, Fac Med, London, England.
   [Khwanda, Ahmad] Kings Coll Hosp NHS Fdn Trust, Cardiol, London, England.
   [Rosen, Stuart D.] Imperial Coll, Natl Heart & Lung Inst, Div Cardiovasc Sci, London SW7 2AZ, England.
C3 Imperial College London; King's College Hospital NHS Foundation Trust;
   Imperial College London
RP Rosen, SD (corresponding author), Imperial Coll, Natl Heart & Lung Inst, Div Cardiovasc Sci, London SW7 2AZ, England.
EM stuart.rosen@imperial.ac.uk
RI Rosen, Stuart/AAE-4649-2020
CR Abdel-Wahab BA, 2014, CHEM-BIOL INTERACT, V216, P43, DOI 10.1016/j.cbi.2014.03.012
   Abdelmawla N., 2006, Advances in Psychiatric Treatment, V12, P35, DOI DOI 10.1192/APT.12.35
   Alawami M, 2014, INT J CARDIOL, V176, P315, DOI 10.1016/j.ijcard.2014.07.103
   Arlington V. A., 2013, Private Man, Vfifth, P5
   Chang HA, 2013, ACTA NEUROPSYCHIATR, V25, P155, DOI 10.1111/acn.12014
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   Correll CU, 2014, JAMA PSYCHIAT, V71, P1350, DOI 10.1001/jamapsychiatry.2014.1314
   Crump C, 2013, AM J PSYCHIAT, V170, P324, DOI 10.1176/appi.ajp.2012.12050599
   Daumit GL, 2008, SCHIZOPHR RES, V105, P175, DOI 10.1016/j.schres.2008.07.006
   De Hert M, 2009, EUR PSYCHIAT, V24, P412, DOI 10.1016/j.eurpsy.2009.01.005
   Djurovic S, MORE LINKS FOUND SCH
   Frangogiannis NG, 2002, CARDIOVASC RES, V53, P31, DOI 10.1016/S0008-6363(01)00434-5
   Glassman AH, 2001, AM J PSYCHIAT, V158, P1774, DOI 10.1176/appi.ajp.158.11.1774
   Hennessy S, 2002, BMJ, V325, P1
   Herbsleb M, 2018, SCHIZOPHR RES, V197, P162, DOI 10.1016/j.schres.2018.02.020
   Honkola J, 2012, EUR HEART J, V33, P745, DOI 10.1093/eurheartj/ehr368
   Hulshof TA, 2015, J AM MED DIR ASSOC, V16, P817, DOI 10.1016/j.jamda.2015.03.015
   Huybrechts KF, 2012, BRIT MED J, V344, DOI 10.1136/bmj.e977
   Kahl KG, 2018, VASC PHARMACOL, V100, P20, DOI 10.1016/j.vph.2017.09.001
   Kilian JG, 1999, LANCET, V354, P1841, DOI 10.1016/S0140-6736(99)10385-4
   Layland JJ, 2009, MED J AUSTRALIA, V190, P190, DOI 10.5694/j.1326-5377.2009.tb02345.x
   Lehnart SE, 2007, CIRCULATION, V116, P2325, DOI 10.1161/CIRCULATIONAHA.107.711689
   Lin CH, 2004, J FORMOS MED ASSOC, V103, P437
   Lin JJ, 2018, SCHIZOPHR RES, V197, P116, DOI 10.1016/j.schres.2018.01.011
   Mitcheson JS, 2000, P NATL ACAD SCI USA, V97, P12329, DOI 10.1073/pnas.210244497
   Okada T, 2003, J CLIN PSYCHOPHARM, V23, P441, DOI 10.1097/01.jcp.0000088901.24613.b8
   Park Y, 2018, BMJ-BRIT MED J, V360, DOI 10.1136/bmj.k1218
   Ray WA, 2001, ARCH GEN PSYCHIAT, V58, P1161, DOI 10.1001/archpsyc.58.12.1161
   Razminia Mansour, 2006, Am J Ther, V13, P274, DOI 10.1097/01.mjt.0000212704.79248.3d
   Reilly JG, 2000, LANCET, V355, P1048, DOI 10.1016/S0140-6736(00)02035-3
   Reilly JG, 2002, BRIT J PSYCHIAT, V180, P515, DOI 10.1192/bjp.180.6.515
   Reinders J, 2004, AUST NZ J PSYCHIAT, V38, P915, DOI 10.1111/j.1440-1614.2004.01481.x
   Ronaldson KJ, 2011, AUST NZ J PSYCHIAT, V45, P458, DOI 10.3109/00048674.2011.572852
   Rosenheck R, 1997, NEW ENGL J MED, V337, P809, DOI 10.1056/NEJM199709183371202
   Rostagno Carlo, 2012, Cardiovascular & Hematological Agents in Medicinal Chemistry, V10, P148
   Royal College of psychiatrists, 1997, CR57 ROYAL COLL PSYC
   Rummel-Kluge C, 2010, SCHIZOPHR RES, V123, P225, DOI 10.1016/j.schres.2010.07.012
   Ruppert J, 2018, EUR ARCH PSY CLIN N, V268, P719, DOI 10.1007/s00406-017-0858-y
   Saha S, 2007, ARCH GEN PSYCHIAT, V64, P1123, DOI 10.1001/archpsyc.64.10.1123
   Salvo F, 2016, CLIN PHARMACOL THER, V99, P306, DOI 10.1002/cpt.250
   Satoh Y, 2000, JPN CIRC J, V64, P445, DOI 10.1253/jcj.64.445
   Seeman P, 2002, CAN J PSYCHIAT, V47, P27, DOI 10.1177/070674370204700106
   Spellmann I, 2018, EUR ARCH PSY CLIN N, V268, P383, DOI 10.1007/s00406-018-0880-8
   Straus SMJM, 2004, ARCH INTERN MED, V164, P1293, DOI 10.1001/archinte.164.12.1293
   Stubbs B, 2018, EUR PSYCHIAT, V54, P124, DOI 10.1016/j.eurpsy.2018.07.004
   Thomas SH, 1994, DRUGS, V13
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vermeulen JM, 2019, SCHIZOPHRENIA BULL, V45, P315, DOI 10.1093/schbul/sby052
   Yoon BW, 1997, ARCH NEUROL-CHICAGO, V54, P741, DOI 10.1001/archneur.1997.00550180055012
NR 49
TC 52
Z9 55
U1 1
U2 11
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1355-6037
EI 1468-201X
J9 HEART
JI Heart
PD DEC
PY 2019
VL 105
IS 24
BP 1852
EP 1859
DI 10.1136/heartjnl-2017-312107
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA JX5UQ
UT WOS:000503800100005
PM 31439658
DA 2025-06-11
ER

PT J
AU Nishida, T
   Tsuneyama, K
   Fujimoto, M
   Nomoto, K
   Hayashi, S
   Miwa, S
   Nakajima, T
   Nakanishi, Y
   Sasaki, Y
   Suzuki, W
   Iizuka, S
   Nagata, M
   Shimada, T
   Aburada, M
   Shimada, Y
   Imura, J
AF Nishida, Takeshi
   Tsuneyama, Koichi
   Fujimoto, Makoto
   Nomoto, Kazuhiro
   Hayashi, Shinichi
   Miwa, Shigeharu
   Nakajima, Takahiko
   Nakanishi, Yuko
   Sasaki, Yoshiyuki
   Suzuki, Wataru
   Iizuka, Seiichi
   Nagata, Mitsunobu
   Shimada, Tsutomu
   Aburada, Masaki
   Shimada, Yutaka
   Imura, Johji
TI Spontaneous onset of nonalcoholic steatohepatitis and hepatocellular
   carcinoma in a mouse model of metabolic syndrome
SO LABORATORY INVESTIGATION
LA English
DT Article
DE animal model; hepatocellular carcinoma; inflammation; nonalcoholic
   steatohepatitis; obesity; oxidative stress; type-2 diabetes
ID FATTY LIVER-DISEASE; OBESE-DIABETIC MOUSE; ADIPOSE-TISSUE;
   GLUTAMINE-SYNTHETASE; INSULIN-RESISTANCE; ANIMAL-MODEL; PPAR-GAMMA;
   EXPRESSION; PIOGLITAZONE; INFLAMMATION
AB Metabolic syndrome is a worldwide healthcare issue and a dominant risk factor for the development of incurable diseases that affect the entire body. The hepatic manifestations of this syndrome include nonalcoholic fatty liver disease (NAFLD) and its progressive variant nonalcoholic steatohepatitis (NASH). The basic pathogenesis of NAFLD/NASH remains controversial because it is difficult to clarify the disease process of NASH on the basis of metabolic syndrome alone. To determine the pathogenesis and effective treatment, an excellent animal model of NASH is required. Tsumura Suzuki obese diabetes (TSOD) male mice spontaneously develop diabetes mellitus, obesity, glucosuria, hyperglycemia, and hyperinsulinemia without any special treatments such as gene manipulation. In this study, we examined the histopathological characteristics of visceral fat and liver of 56 male TSOD mice aged 4-17 months and 9 male Tsumura Suzuki non-obesity (control) mice aged 6-12 months. In the visceral fat, enlargement of adipocytes and perivascular and pericapsular CD8-positive lymphoid aggregation were observed in 4-month-old mice. Abnormal expression of tumor necrosis factor-a, interleukin-6, and lipid peroxidation endo products was observed in macrophages. In the liver, microvesicular steatosis, hepatocellular ballooning, and Mallory bodies were observed in 4-month-old mice, with severity worsening with increasing time. These pathological findings in the liver mimic those seen in patients with NASH. Interestingly, small liver nodules with high cellularity and absence of portal tracts were frequently observed after 12 months. Most of them showed nuclear and structural atypia, and mimicked human hepatocellular carcinoma. The degree of steatosis in the non-tumor portions of the liver improved when the liver nodules developed. These findings were not observed in control mice. Here, we report that TSOD male mice spontaneously developed NAFLD without any special treatment, and that these mice are a valuable model for assessing NASH and NASH carcinogenesis owing to metabolic syndrome. Laboratory Investigation (2013) 93, 230-241; doi:10.1038/labinvest.2012.155; published online 19 November 2012
C1 [Nishida, Takeshi; Tsuneyama, Koichi; Nomoto, Kazuhiro; Hayashi, Shinichi; Miwa, Shigeharu; Nakajima, Takahiko; Nakanishi, Yuko; Imura, Johji] Toyama Univ, Dept Diagnost Pathol, Grad Sch Med & Pharmaceut Sci, Toyama 9300194, Japan.
   [Fujimoto, Makoto; Shimada, Yutaka] Toyama Univ, Dept Japanese Oriental Med, Grad Sch Med & Pharmaceut Sci, Toyama 9300194, Japan.
   [Sasaki, Yoshiyuki; Suzuki, Wataru; Iizuka, Seiichi; Nagata, Mitsunobu; Shimada, Tsutomu; Aburada, Masaki] Musashino Univ, Pharmaceut Sci Res Inst, Fac Pharm, Tokyo, Japan.
   [Sasaki, Yoshiyuki] Inst Anim Reprod, Kasumigaura, Japan.
C3 University of Toyama; University of Toyama
RP Tsuneyama, K (corresponding author), Toyama Univ, Dept Diagnost Pathol, Grad Sch Med & Pharmaceut Sci, 2630 Sugitani, Toyama 9300194, Japan.
EM ktsune@med.u-toyama.ac.jp
OI Tsuneyama, Koichi/0000-0002-0670-9868
FU Japan Society for the Promotion Science [24390181, 21590433]; Takeda
   Science Foundation, Japan; TSOD Mouse Research Fund; Grants-in-Aid for
   Scientific Research [21590433, 24390181, 25460413] Funding Source: KAKEN
FX We thank Tokimasa Kumada, Hideki Hatta, and Chieko Kiya for their help
   and technical assistance in the experiments. We would also like to thank
   Yukari Inoue for her support during the preparation of this manuscript.
   We would like to express our appreciation to Dr Ulrich Deuschle (Phenex
   Pharmaceuticals AG, Germany) for his valuable advice. The project was
   supported in part by Grant-in Aid-for Scientific Research (B and C),
   Japan Society for the Promotion Science (24390181 and 21590433), Takeda
   Science Foundation, Japan (2010), and TSOD Mouse Research Fund.
CR ABDELMALEK M, 1995, J CLIN GASTROENTEROL, V20, P127, DOI 10.1097/00004836-199503000-00011
   [Anonymous], CLIN LIVER DIS
   Anstee QM, 2006, INT J EXP PATHOL, V87, P1, DOI 10.1111/j.0959-9673.2006.00465.x
   Brunt EM, 2001, SEMIN LIVER DIS, V21, P3, DOI 10.1055/s-2001-12925
   Bugianesi E, 2007, Clin Liver Dis, V11, P191, DOI 10.1016/j.cld.2007.02.006
   Cadoret A, 2002, ONCOGENE, V21, P8293, DOI 10.1038/sj.onc.1206118
   Centis E, 2010, DIGEST DIS, V28, P267, DOI 10.1159/000282101
   Charlton M, 2004, CLIN GASTROENTEROL H, V2, P1048, DOI 10.1016/S1542-3565(04)00440-9
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   Deng QG, 2005, HEPATOLOGY, V42, P905, DOI 10.1002/hep.20877
   Di Tommaso L, 2007, HEPATOLOGY, V45, P725, DOI 10.1002/hep.21531
   Dowman JK, 2011, DIABETES OBES METAB, V13, P692, DOI 10.1111/j.1463-1326.2011.01403.x
   Farrell GC, 2006, HEPATOLOGY, V43, pS99, DOI 10.1002/hep.20973
   Gazit V, 2012, HEPATOLOGY, V56, P1489, DOI 10.1002/hep.25880
   Hirayama I, 1999, DIABETES, V48, P1183, DOI 10.2337/diabetes.48.5.1183
   Iizuka S, 2005, EXP ANIM TOKYO, V54, P71, DOI 10.1538/expanim.54.71
   Inoue M, 2005, BIOCHEM BIOPH RES CO, V336, P215, DOI 10.1016/j.bbrc.2005.08.070
   Itoh M, 2011, AM J PATHOL, V179, P2454, DOI 10.1016/j.ajpath.2011.07.014
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Memon RA, 2000, ENDOCRINOLOGY, V141, P4021, DOI 10.1210/en.141.11.4021
   Miura T, 2001, EUR J ENDOCRINOL, V145, P785, DOI 10.1530/eje.0.1450785
   Nagata M, 2006, EXP ANIM TOKYO, V55, P109, DOI 10.1538/expanim.55.109
   Nakanishi Y, 2008, HEPATOL RES, V38, P1241, DOI 10.1111/j.1872-034X.2008.00395.x
   Nakanishi Y, 2008, J AUTOIMMUN, V30, P42, DOI 10.1016/j.jaut.2007.11.016
   Nishimura S, 2009, NAT MED, V15, P914, DOI 10.1038/nm.1964
   Nomoto K, 2006, J PATHOL, V210, P469, DOI 10.1002/path.2065
   Ong Janus P, 2007, Clin Liver Dis, V11, P1, DOI 10.1016/j.cld.2007.02.009
   POWELL EE, 1990, HEPATOLOGY, V11, P74, DOI 10.1002/hep.1840110114
   Ramadori P, 2010, LAB INVEST, V90, P1306, DOI 10.1038/labinvest.2010.85
   Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929
   Shah P, 2010, EXPERT OPIN DRUG SAF, V9, P347, DOI 10.1517/14740331003623218
   Shimada T, 2008, BIOL PHARM BULL, V31, P1362, DOI 10.1248/bpb.31.1362
   Shimada T, 2012, EUR J PHARMACOL, V677, P147, DOI 10.1016/j.ejphar.2011.12.034
   Sugimoto K, 2011, HEPATOL RES, V41, P911, DOI 10.1111/j.1872-034X.2011.00867.x
   Suzuki W, 1999, EXP ANIM TOKYO, V48, P181, DOI 10.1538/expanim.48.181
   Takahashi A, 2006, METABOLISM, V55, P1664, DOI 10.1016/j.metabol.2006.08.007
   Tremosini S, 2012, GUT, V61, P1481, DOI 10.1136/gutjnl-2011-301862
   Yang ZH, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-120
   Yki-Järvinen H, 2009, CURR OPIN LIPIDOL, V20, P477, DOI 10.1097/MOL.0b013e3283321d37
   Yoneda Masato, 2006, Nihon Rinsho, V64, P1139
   Yoshioka Y, 2004, J GASTROENTEROL, V39, P1215, DOI 10.1007/s00535-004-1475-x
   Zucman-Rossi J, 2007, ONCOGENE, V26, P774, DOI 10.1038/sj.onc.1209824
   Zucman-Rossi J, 2006, HEPATOLOGY, V43, P515, DOI 10.1002/hep.21068
NR 43
TC 51
Z9 54
U1 0
U2 18
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0023-6837
EI 1530-0307
J9 LAB INVEST
JI Lab. Invest.
PD FEB
PY 2013
VL 93
IS 2
BP 230
EP 241
DI 10.1038/labinvest.2012.155
PG 12
WC Medicine, Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pathology
GA 084SF
UT WOS:000314558700009
PM 23212097
OA Bronze
DA 2025-06-11
ER

PT J
AU Zhang, RW
   Peng, L
   Cai, Q
   Xu, Y
   Liu, ZX
   Liu, YM
AF Zhang, Renwei
   Peng, Li
   Cai, Qi
   Xu, Yao
   Liu, Zhenxing
   Liu, Yumin
TI Development and validation of a predictive model for white matter
   lesions in young- and middle-aged people
SO FRONTIERS IN NEUROLOGY
LA English
DT Article
DE white matter lesions; carotid plaque score; diastolic blood pressure;
   metabolic syndrome; nomogram
ID SMALL VESSEL DISEASE; BLOOD-PRESSURE; RISK; HYPERINTENSITY; BRAIN;
   LEUKOARAIOSIS; ASSOCIATIONS; PREVALENCE; DEPRESSION; OBESITY
AB Background White matter lesion (WML) is an age-related disorder associated with stroke and cognitive impairment. This study aimed to investigate the risk factors and build a predictive model of WML in young- and middle-aged people.Methods We performed a second analysis of the data from the Dryad Digital Repository. We selected those people who are <60 years old and randomly divided them into the training group and the validation group. We investigated the risk factors of WML in the training group with logistic regression analysis and built a prediction nomogram based on multivariate logistic regression analysis; finally, the performance of the prediction nomogram was evaluated for discrimination, accuracy, and clinical utility.Results There were 308 people in the training group and 723 people in the validation group. Multivariate regression analysis showed that the age (OR = 1.49, 95% CI: 1.31-1.70), diastolic blood pressure (OR = 1.02, 95% CI: 1.00-1.03), carotid plaque score (OR = 1.31, 95% CI: 1.14-1.50), female gender (OR = 2.27, 95% CI: 1.56-3.30), and metabolic syndrome (OR = 2.12, 95% CI: 1.22-3.70) were significantly associated with white matter lesions. The area under the curve value (AUC) of the receiver operating curve (ROC) was 0.734 for the training group and 0.642 for the validation group. The calibration curve and clinical impact curve showed that the prediction nomogram has good accuracy and clinical application value.Conclusion Age, diastolic blood pressure, carotid plaque score, female gender, and metabolic syndrome were risk factors in young- and middle-aged people <60 years old with WML, and the nomogram based on these risk factors showed good discrimination, accuracy, and clinical utility.
C1 [Zhang, Renwei; Cai, Qi; Xu, Yao; Liu, Yumin] Wuhan Univ, Dept Neurol, Zhongnan Hosp, Wuhan, Peoples R China.
   [Peng, Li] Wuhan Univ, Zhongnan Hosp, Dept Cardiol, Wuhan, Peoples R China.
   [Liu, Zhenxing] Yiling Hosp Yichang, Dept Neurol, Yichang, Peoples R China.
C3 Wuhan University; Wuhan University
RP Liu, YM (corresponding author), Wuhan Univ, Dept Neurol, Zhongnan Hosp, Wuhan, Peoples R China.; Liu, ZX (corresponding author), Yiling Hosp Yichang, Dept Neurol, Yichang, Peoples R China.
EM 200432180216@whu.edu.cn; liuyumin9381@126.com
RI Liu, Zhenxing/GXH-9193-2022
FU The author(s) declare that no financial support was received for the
   research, authorship, and/or publication of this article.
FX The author(s) declare that no financial support was received for the
   research, authorship, and/or publication of this article.
CR Alber J, 2019, ALZH DEMENT-TRCI, V5, P107, DOI 10.1016/j.trci.2019.02.001
   Anand SS, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2021.46324
   Bahrani AA, 2017, J STROKE CEREBROVASC, V26, P779, DOI 10.1016/j.jstrokecerebrovasdis.2016.10.017
   Berman SE, 2015, NEUROIMAGE-CLIN, V9, P216, DOI 10.1016/j.nicl.2015.08.011
   Brown R, 2021, J NEUROL NEUROSUR PS, V92, P1271, DOI 10.1136/jnnp-2021-326569
   Buyck JF, 2009, STROKE, V40, P2327, DOI 10.1161/STROKEAHA.109.548222
   Carey RM, 2022, JAMA-J AM MED ASSOC, V328, P1849, DOI 10.1001/jama.2022.19590
   Caunca MR, 2020, STROKE, V51, P372, DOI 10.1161/STROKEAHA.119.025139
   de Leeuw FE, 2001, J NEUROL NEUROSUR PS, V70, P9, DOI 10.1136/jnnp.70.1.9
   Debette S, 2010, STROKE, V41, P600, DOI 10.1161/STROKEAHA.109.570044
   Després JP, 2021, J AM COLL CARDIOL, V78, P513, DOI 10.1016/j.jacc.2021.05.035
   Devantier TA, 2016, PSYCHOSOMATICS, V57, P369, DOI 10.1016/j.psym.2016.02.005
   Frey BM, 2019, FRONT NEUROL, V10, DOI 10.3389/fneur.2019.00238
   Ikram MA, 2009, NEUROBIOL AGING, V30, P450, DOI 10.1016/j.neurobiolaging.2007.07.009
   Jimenez-Conde J, 2010, STROKE, V41, P437, DOI 10.1161/STROKEAHA.109.563502
   Kandiah N, 2014, J STROKE CEREBROVASC, V23, P136, DOI 10.1016/j.jstrokecerebrovasdis.2012.11.007
   Kang P, 2022, STROKE, V53, P1570, DOI 10.1161/STROKEAHA.121.035674
   Kim KW, 2017, INT J OBESITY, V41, P683, DOI 10.1038/ijo.2017.13
   Kleindorfer DO, 2021, STROKE, V52, pE364, DOI 10.1161/STR.0000000000000375
   Leung LY, 2017, ARTERIOSCL THROM VAS, V37, P1579, DOI 10.1161/ATVBAHA.117.309298
   Li J, 2023, EUR REV MED PHARMACO, V27, P151, DOI 10.26355/eurrev_202301_30866
   Lin Q, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000007682
   Marek M, 2018, POL J RADIOL, V83, pE76, DOI 10.5114/pjr.2018.74344
   Martínez-Montoro JI, 2023, OBES REV, V24, DOI 10.1111/obr.13599
   McEwen BS, 2001, J APPL PHYSIOL, V91, P2785, DOI 10.1152/jappl.2001.91.6.2785
   Morito N, 2008, J CARDIOL, V51, P25, DOI 10.1016/j.jjcc.2007.09.003
   Petrone AB, 2014, AGING DIS, V5, P340, DOI 10.14336/AD.2014.0500340
   Ryu WS, 2014, STROKE, V45, P3567, DOI 10.1161/STROKEAHA.114.006662
   Shinkawa Y, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0215142
   Tully PJ, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2017-018328
   Tully PJ, 2017, AM J GERIAT PSYCHIAT, V25, P1311, DOI 10.1016/j.jagp.2017.06.003
   van den Heuvel DMJ, 2004, NEUROLOGY, V63, P1699, DOI 10.1212/01.WNL.0000143058.40388.44
   Wardlaw JM, 2001, J NEUROL NEUROSUR PS, V70, P2, DOI 10.1136/jnnp.70.1.2
   Wardlaw JM, 2015, J AM HEART ASSOC, V4, DOI 10.1161/JAHA.114.001140
   Wardlaw JM, 2013, LANCET NEUROL, V12, P822, DOI 10.1016/S1474-4422(13)70124-8
   Wormser D, 2011, LANCET, V377, P1085, DOI 10.1016/S0140-6736(11)60105-0
   Zhang L, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.665573
   Zheng K, 2023, BRAIN SCI, V13, DOI 10.3390/brainsci13050835
NR 38
TC 0
Z9 0
U1 1
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD OCT 19
PY 2023
VL 14
AR 1257795
DI 10.3389/fneur.2023.1257795
PG 13
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA X1QX1
UT WOS:001096274700001
PM 37928162
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Das, A
   Nairn, S
AF Das, Aniruddha
   Nairn, Stephanie
TI Religious Attendance and Physiological Problems in Late Life
SO JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL
   SCIENCES
LA English
DT Article
DE Inflammation; Late life; Physiology; Religious attendance; Spousal loss;
   Weathering
ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; MENTAL-HEALTH; OLDER-ADULTS;
   PSYCHOLOGICAL DISTRESS; GENDER DIFFERENCES; MODERATED REGRESSION;
   DEPRESSIVE SYMPTOMS; ETHNIC-DIFFERENCES; METABOLIC SYNDROME
AB Objectives: This study queried linkages of older adults' religious attendance with their physiological health.
   Method: Data were from the 2005-2006 National Social Life, Health, and Aging Project, nationally representative of U.S. adults aged 57-85 years. Analyses examined associations of religious attendance with biological states, potential gender variations in these linkages, and attenuation by this factor of health effects of spousal loss.
   Results: Religious attendance was negatively associated with a system of physiological issues, consistent with mitigation of multisystemic "weathering." Linkages were relatively uniform with inflammatory and cardiovascular but not metabolic states and were not significantly different for women than men. Effects of spousal loss on the 2 former subsystems were attenuated by regular religious attendance-in combined-gender analysis and among women, but not men.
   Discussion: Religious attendance may buffer older adults from physiological problems and the health effects of life events such as spousal loss. More intensive analysis is needed to explain differential linkages with specific biological subsystems.
C1 [Das, Aniruddha; Nairn, Stephanie] McGill Univ, Dept Sociol, Room 712,Leacock Bldg,855 Sherbrooke St West, Montreal, PQ H3A 2T7, Canada.
   [Das, Aniruddha] McGill Univ, Ctr Populat Dynam, Montreal, PQ H3A 2T7, Canada.
C3 McGill University; McGill University
RP Das, A (corresponding author), McGill Univ, Dept Sociol, Room 712,Leacock Bldg,855 Sherbrooke St West, Montreal, PQ H3A 2T7, Canada.
EM aniruddha.das@mcgill.ca
RI Nairn, Stephanie/JQW-4646-2023
OI Nairn, Stephanie/0000-0002-6273-0290
CR Agresti A., 2007, INTRO CATEGORICAL DA
   Ariyo AA, 2000, CIRCULATION, V102, P1773
   Balbuena L, 2013, CAN J PSYCHIAT, V58, P225, DOI 10.1177/070674371305800408
   BARUSCH AS, 1989, GERONTOLOGIST, V29, P667, DOI 10.1093/geront/29.5.667
   Becker G.S., 1981, TREATISE FAMILY, DOI DOI 10.4159/9780674020665
   Bednarowski M. F., 1999, RELIG IMAGINATION AM, P16
   Bierhaus A, 2003, P NATL ACAD SCI USA, V100, P1920, DOI 10.1073/pnas.0438019100
   BOOTH A, 1991, J HEALTH SOC BEHAV, V32, P396, DOI 10.2307/2137106
   Bradshaw M, 2010, SOC SCI MED, V71, P196, DOI 10.1016/j.socscimed.2010.03.015
   Brines J, 1999, AM SOCIOL REV, V64, P333, DOI 10.2307/2657490
   Buck AC, 2009, SOC SCI MED, V68, P314, DOI 10.1016/j.socscimed.2008.10.010
   Butts CT, 2004, J MATH SOCIOL, V28, P81, DOI 10.1080/00222500490448208
   Calhoun D, 2010, J DIABETES COMPLICAT, V24, P217, DOI 10.1016/j.jdiacomp.2009.03.005
   Carr D, 2003, J HEALTH SOC BEHAV, V44, P215, DOI 10.2307/1519809
   Carr D, 2004, J MARRIAGE FAM, V66, P1051, DOI 10.1111/j.0022-2445.2004.00078.x
   Carr D., 2002, AGEING INT, V27, P65, DOI DOI 10.1007/S12126-001-1016-3
   Christakis NA, 2006, NEW ENGL J MED, V354, P719, DOI 10.1056/NEJMsa050196
   Cohen J., 1988, STAT POWER ANAL BEHA, DOI [10.4324/9780203771587, DOI 10.4324/9780203771587]
   Cooney TM, 2001, J FAM ISSUES, V22, P838, DOI 10.1177/019251301022007003
   Daaleman TP, 2004, ANN FAM MED, V2, P49, DOI 10.1370/afm.20
   Danesh J, 2000, BMJ-BRIT MED J, V321, P199, DOI 10.1136/bmj.321.7255.199
   Das A, 2013, J AGING HEALTH, V25, P221, DOI 10.1177/0898264312464498
   Das A, 2013, SOC SCI MED, V77, P75, DOI 10.1016/j.socscimed.2012.11.007
   Das Aniruddha., 2012, Sex for life: From virginity to Viagra, how sexuality changes throughout our lives, P236
   de Wit L, 2010, PSYCHIAT RES, V178, P230, DOI 10.1016/j.psychres.2009.04.015
   Dohrenwend BP, 2006, PSYCHOL BULL, V132, P477, DOI 10.1037/0033-2909.132.3.477
   Elder GH., 1985, Life Course Dynamics: Trajectories and Transitions, 1968-1980
   Ellaway A, 2007, SOC SCI MED, V64, P1384, DOI 10.1016/j.socscimed.2006.11.022
   Ellison CG, 2009, SOC SCI RES, V38, P656, DOI 10.1016/j.ssresearch.2009.02.002
   Elwert F, 2006, AM SOCIOL REV, V71, P16, DOI 10.1177/000312240607100102
   England P, 2009, POPUL DEV REV, V35, P797, DOI 10.1111/j.1728-4457.2009.00309.x
   FRECSKA E, 1989, ETHOS, V17, P70, DOI 10.1525/eth.1989.17.1.02a00040
   Fry PS, 2001, GERONTOLOGIST, V41, P787, DOI 10.1093/geront/41.6.787
   Gadalla T.M., 2008, J DIVORCE REMARRIAGE, V49, P225, DOI 10.1080/10502550802222493
   Gadalla T.M., 2009, Journal of Divorce Remarriage, V50, P55, DOI DOI 10.1080/10502550802365714
   Geronimus AT, 2006, AM J PUBLIC HEALTH, V96, P826, DOI 10.2105/AJPH.2004.060749
   Gotlib I.H., 1997, STRESS ADVERSITY LIF
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Harrell FE, 2001, Regression Modeling Strategies: With Applications to Linear Models, Logistic Regression, and Survival Analysis
   Hayward MD, 2004, DEMOGRAPHY, V41, P87, DOI 10.1353/dem.2004.0005
   Hetherington E.M., 2002, BETTER WORSE
   Hintikka J, 2000, J NERV MENT DIS, V188, P772, DOI 10.1097/00005053-200011000-00008
   Hughes ME, 2009, J HEALTH SOC BEHAV, V50, P344, DOI 10.1177/002214650905000307
   Hughes ME, 2004, RES AGING, V26, P655, DOI 10.1177/0164027504268574
   Johnson NJ, 2000, ANN EPIDEMIOL, V10, P224, DOI 10.1016/S1047-2797(99)00052-6
   KATZ S, 1983, J AM GERIATR SOC, V31, P721, DOI 10.1111/j.1532-5415.1983.tb03391.x
   KATZ S, 1970, GERONTOLOGIST, V10, P20, DOI 10.1093/geront/10.1_Part_1.20
   Kaufman G, 2006, J FAM ISSUES, V27, P735, DOI 10.1177/0192513X05285293
   Keene JR, 2008, AGEING SOC, V28, P551, DOI 10.1017/S0144686X07006654
   Kiecolt-Glaser JK, 2010, NEUROSCI BIOBEHAV R, V35, P33, DOI 10.1016/j.neubiorev.2009.09.003
   Kington RS, 1997, AM J PUBLIC HEALTH, V87, P805, DOI 10.2105/AJPH.87.5.805
   Koenig HG, 1998, J NERV MENT DIS, V186, P513, DOI 10.1097/00005053-199809000-00001
   Koenig HG, 1999, J GERONTOL A-BIOL, V54, pM370, DOI 10.1093/gerona/54.7.M370
   Koenig HG, 2004, J AM GERIATR SOC, V52, P554, DOI 10.1111/j.1532-5415.2004.52161.x
   Koenig HG, 1998, INT J PSYCHIAT MED, V28, P189, DOI 10.2190/75JM-J234-5JKN-4DQD
   Krause N, 2002, SOCIOL RELIG, V63, P21, DOI 10.2307/3712538
   Krause N., 2008, AGING RELIG SOCIAL R
   Lampert R, 2009, J AM COLL CARDIOL, V53, P774, DOI 10.1016/j.jacc.2008.10.053
   Lawler-Row KA, 2010, PSYCHOL RELIG SPIRIT, V2, P1, DOI 10.1037/a0017584
   Lee GR, 2001, J GERONTOL B-PSYCHOL, V56, pS56, DOI 10.1093/geronb/56.1.S56
   Levin J, 2008, J RELIG SPIRITUAL A, V20, P153, DOI 10.1080/15528030801922103
   LILLARD LA, 1995, AM J SOCIOL, V100, P1131, DOI 10.1086/230634
   Lindau ST, 2007, NEW ENGL J MED, V357, P762, DOI 10.1056/NEJMoa067423
   Lustman PJ, 2000, DIABETES CARE, V23, P934, DOI 10.2337/diacare.23.7.934
   Mahay J., 2004, The sexual organization of the city, P127
   MARTIN WS, 1978, J MARKETING RES, V15, P304, DOI 10.2307/3151268
   Maselko J, 2007, PSYCHOSOM MED, V69, P464, DOI 10.1097/PSY.0b013e31806c7c57
   McDade TW, 2006, PSYCHOSOM MED, V68, P376, DOI 10.1097/01.psy.0000221371.43607.64
   McDade TW, 2009, BIODEMOGR SOC BIOL, V55, P159, DOI 10.1080/19485560903382478
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   McFarland MJ, 2010, J GERONTOL B-PSYCHOL, V65, P621, DOI 10.1093/geronb/gbp112
   Melamed S, 2006, PSYCHOL BULL, V132, P327, DOI 10.1037/0033-2909.132.3.327
   Nooney J, 2002, J SCI STUD RELIG, V41, P359, DOI 10.1111/1468-5906.00122
   O'Muircheartaigh C., 2007, NSHAP NATL SOCIAL LI
   O'Muircheartaigh C, 2009, J GERONTOL B-PSYCHOL, V64, pI12, DOI 10.1093/geronb/gbp045
   Cokley KO, 2013, MENT HEALTH RELIG CU, V16, P445, DOI 10.1080/13674676.2012.684346
   Pargament KennethI., 1997, The Psychology of Religion and Coping
   Pargament KI, 2000, J CLIN PSYCHOL, V56, P519, DOI 10.1002/(SICI)1097-4679(200004)56:4<519::AID-JCLP6>3.3.CO;2-T
   Pargament KI, 1998, J SCI STUD RELIG, V37, P710, DOI 10.2307/1388152
   Pearlin L.I., 1999, HDB SOCIOLOGY MENTAL, DOI DOI 10.1007/0-387-36223-1_19
   Pixley JE, 2008, WORK OCCUPATION, V35, P127, DOI 10.1177/0730888408315543
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   RUSSELL CJ, 1992, J APPL PSYCHOL, V77, P336, DOI 10.1037/0021-9010.77.3.336
   RUSSELL CJ, 1991, APPL PSYCH MEAS, V15, P257, DOI 10.1177/014662169101500305
   Saver JL, 1997, J NEUROPSYCH CLIN N, V9, P498
   SCHAEFER C, 1995, AM J EPIDEMIOL, V141, P1142, DOI 10.1093/oxfordjournals.aje.a117387
   Schieman S, 2006, J SCI STUD RELIG, V45, P529, DOI 10.1111/j.1468-5906.2006.00326.x
   Schulz R, 2003, NEW ENGL J MED, V349, P1936, DOI 10.1056/NEJMsa035373
   Schulz R, 1997, AGING MENT HEALTH, V1, P269, DOI 10.1080/13607869757173
   Seeman T, 2008, SOC SCI MED, V66, P72, DOI 10.1016/j.socscimed.2007.08.027
   Shinn EH, 2001, AM J HYPERTENS, V14, P660, DOI 10.1016/S0895-7061(01)01304-8
   Singer B., 2004, ALLOSTASIS HOMEOSTAS, P113, DOI DOI 10.1017/CBO9781316257081.007
   SMITH KR, 1991, DEMOGRAPHY, V28, P361, DOI 10.2307/2061462
   Sosis R, 2003, EVOL ANTHROPOL, V12, P264, DOI 10.1002/evan.10120
   Stata Corp, 2011, STATA REL 12 1
   STERLING P, 1981, SOC SCI MED-MED PSYC, V15, P3, DOI 10.1016/S0277-9536(81)80005-6
   STONE R, 1987, GERONTOLOGIST, V27, P616, DOI 10.1093/geront/27.5.616
   Strawbridge WJ, 1997, AM J PUBLIC HEALTH, V87, P957, DOI 10.2105/AJPH.87.6.957
   Strawbridge WJ, 2001, ANN BEHAV MED, V23, P68, DOI 10.1207/S15324796ABM2301_10
   Sweeney MM, 2010, J MARRIAGE FAM, V72, P667, DOI 10.1111/j.1741-3737.2010.00724.x
   Tamborini CR, 2009, RES AGING, V31, P577, DOI 10.1177/0164027509337196
   TAYLOR RJ, 1988, REV RELIG RES, V30, P193, DOI 10.2307/3511355
   Thoits PA, 2010, J HEALTH SOC BEHAV, V51, pS41, DOI 10.1177/0022146510383499
   Ulker A, 2009, J FAM ECON ISS, V30, P90, DOI 10.1007/s10834-008-9139-2
   Webb AP, 2010, FAM RELAT, V59, P544, DOI 10.1111/j.1741-3729.2010.00622.x
   Weinstein Maxine., 2007, Biosocial Surveys
   WHEATON B, 1990, AM SOCIOL REV, V55, P209, DOI 10.2307/2095627
   Williams K, 2003, J HEALTH SOC BEHAV, V44, P470, DOI 10.2307/1519794
   Williams SR, 2009, J GERONTOL B-PSYCHOL, V64, pI131, DOI 10.1093/geronb/gbn022
   Wilmoth J, 2002, J MARRIAGE FAM, V64, P254, DOI 10.1111/j.1741-3737.2002.00254.x
   Woo IMH, 2008, OMEGA-J DEATH DYING, V58, P275, DOI 10.2190/OM.58.4.b
   Yudkin JS, 2003, INT J OBESITY, V27, pS25, DOI 10.1038/sj.ijo.0802496
NR 113
TC 19
Z9 20
U1 0
U2 4
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5014
EI 1758-5368
J9 J GERONTOL B-PSYCHOL
JI J. Gerontol. Ser. B-Psychol. Sci. Soc. Sci.
PD MAR
PY 2016
VL 71
IS 2
BP 291
EP 308
DI 10.1093/geronb/gbu089
PG 18
WC Geriatrics & Gerontology; Gerontology; Psychology; Psychology,
   Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychology
GA DP0FD
UT WOS:000378163200010
PM 25098525
OA Bronze
DA 2025-06-11
ER

PT J
AU Bensenor, IM
AF Bensenor, I. M.
TI Thyroid disorders in Brazil: the contribution of the Brazilian
   Longitudinal Study of Adult Health (ELSA-Brasil)
SO BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
LA English
DT Article
DE Subclinical thyroid diseases; Hyperthyroidism; Hypothyroidism;
   Subclinical atherosclerosis; Cardiovascular diseases; Mental health
ID INTIMA-MEDIA THICKNESS; CORONARY-ARTERY CALCIFICATION; PULSE-WAVE
   VELOCITY; C-REACTIVE PROTEIN; CROSS-SECTIONAL ANALYSIS;
   HEART-RATE-VARIABILITY; GLOMERULAR-FILTRATION-RATE; CHRONIC
   KIDNEY-DISEASE; SERUM TSH LEVEL; SUBCLINICAL HYPOTHYROIDISM
AB Thyroid disorders are common diseases, both in Brazil and worldwide. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is a prospective cohort study that investigates cardiovascular diseases, diabetes, and associated factors, including non-classical cardiovascular risk factors such as thyroid function. Thyroid function was classified according to thyrotropin stimulating hormone (TSH), free thyroxine (FT4), and use of medication to treat thyroid disorders, after excluding participants who reported use of any medication that could alter the results of the TSH and FT4 tests. All analyses included in this review are crosssectional using baseline data (2008 to 2010). The results showed an association of subclinical thyroid disorders with biomarkers of subclinical atherosclerosis, measured by carotid intima-media thickness and coronary artery calcium, insulin resistance, metabolic syndrome, and some psychiatric disorders. No association was found with the biomarker of inflammation high-sensitivity C-reactive protein, or changes in pulse wave velocity or heart rate variability.
C1 [Bensenor, I. M.] Univ Sao Paulo, Hosp Univ, Ctr Pesquisa Clin & Epidemiol, Sao Paulo, SP, Brazil.
   [Bensenor, I. M.] Univ Sao Paulo, Fac Med, Dept Clin Med, Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo
RP Bensenor, IM (corresponding author), Univ Sao Paulo, Hosp Univ, Ctr Pesquisa Clin & Epidemiol, Sao Paulo, SP, Brazil.; Bensenor, IM (corresponding author), Univ Sao Paulo, Fac Med, Dept Clin Med, Sao Paulo, SP, Brazil.
EM isabensenor@gmail.com
RI Bensenor, Isabela/L-3306-2017
OI Bensenor, Isabela/0000-0002-6723-5678
CR Al Sayed A, 2006, ENDOCR J, V53, P653, DOI 10.1507/endocrj.K06-018
   Almeida C, 2007, REV BRAS PSIQUIATR, V29, P157, DOI 10.1590/S1516-44462007000200013
   Aquino EML, 2012, AM J EPIDEMIOL, V175, P315, DOI 10.1093/aje/kwr294
   Åsvold BO, 2011, EUR J ENDOCRINOL, V164, P101, DOI 10.1530/EJE-10-0705
   Auer J, 2003, CLIN CARDIOL, V26, P569, DOI 10.1002/clc.4960261205
   Benseñor IM, 2016, CLIN ENDOCRINOL, V84, P250, DOI 10.1111/cen.12719
   Benseñor IM, 2015, METAB SYNDR RELAT D, V13, P362, DOI 10.1089/met.2015.0045
   Bensenor IM, 2013, REV SAUDE PUBL, V47, P37, DOI 10.1590/S0034-8910.2013047003780
   Benseñor IM, 2011, CAD SAUDE PUBLICA, V27, P155, DOI 10.1590/S0102-311X2011000100016
   Benseñor IM, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-298
   Celik A, 2011, ANN NONINVAS ELECTRO, V16, P344, DOI 10.1111/j.1542-474X.2011.00461.x
   Ceresini G, 2009, J AM GERIATR SOC, V57, P89, DOI 10.1111/j.1532-5415.2008.02080.x
   Chonchol M, 2008, CLIN J AM SOC NEPHRO, V3, P1296, DOI 10.2215/CJN.00800208
   Chor D, 2013, REV SAUDE PUBL, V47, P27, DOI 10.1590/S0034-8910.2013047003835
   Christ-Crain M, 2003, ATHEROSCLEROSIS, V166, P379, DOI 10.1016/S0021-9150(02)00372-6
   Chueire VB, 2007, ARCH GERONTOL GERIAT, V44, P21, DOI 10.1016/j.archger.2006.02.001
   Collet TH, 2012, ARCH INTERN MED, V172, P799, DOI 10.1001/archinternmed.2012.402
   Garduño-Garcia JD, 2010, EUR J ENDOCRINOL, V163, P273, DOI 10.1530/EJE-10-0312
   de Miranda EJFP, 2017, CLIN EXP NEPHROL, V21, P1035, DOI 10.1007/s10157-017-1400-2
   Delitala AP, 2015, NUTR METAB CARDIOVAS, V25, P1104, DOI 10.1016/j.numecd.2015.09.001
   Diaz-Olmos R, 2010, SAO PAULO MED J, V128, P18, DOI 10.1590/S1516-31802010000100005
   Falcone C, 2014, INT HEART J, V55, P33, DOI 10.1536/ihj.13-198
   Fedeli LG, 2013, REV SAUDE PUBL, V47, P63, DOI 10.1590/S0034-8910.2013047003807
   Galetta F, 2006, BIOMED PHARMACOTHER, V60, P425, DOI 10.1016/j.biopha.2006.07.009
   Gao N, 2013, ATHEROSCLEROSIS, V227, P18, DOI 10.1016/j.atherosclerosis.2012.10.070
   Geng J, 2015, ENDOCRINE, V49, P557, DOI 10.1007/s12020-014-0472-y
   Goichot B, 2004, J ENDOCRINOL INVEST, V27, P348, DOI 10.1007/BF03351060
   Gussekloo J, 2004, JAMA-J AM MED ASSOC, V292, P2591, DOI 10.1001/jama.292.21.2591
   Hogervorst E, 2008, PSYCHONEUROENDOCRINO, V33, P1013, DOI 10.1016/j.psyneuen.2008.05.008
   Hueston WJ, 2005, CLIN ENDOCRINOL, V63, P582, DOI 10.1111/j.1365-2265.2005.02388.x
   Jorde R, 2008, THYROID, V18, P21, DOI 10.1089/thy.2007.0165
   Juárez-Cedillo T, 2017, J ENDOCRINOL INVEST, V40, P945, DOI 10.1007/s40618-017-0654-6
   Kalmijn S, 2000, CLIN ENDOCRINOL, V53, P733, DOI 10.1046/j.1365-2265.2000.01146.x
   Kikuchi M, 2005, PROG NEURO-PSYCHOPH, V29, P77, DOI 10.1016/j.pnpbp.2004.10.008
   Lai Y, 2001, ENDOCR J, V58, P23, DOI DOI 10.1507/END0CRJ.K10E-272
   Lee MW, 2014, ENDOCRINOL METAB, V29, P154, DOI 10.3803/EnM.2014.29.2.154
   Lee Yeo Kyung, 2011, Korean Journal of Internal Medicine, V26, P432, DOI 10.3904/kjim.2011.26.4.432
   Levey AS, 2009, ANN INTERN MED, V150, P604, DOI 10.7326/0003-4819-150-9-200905050-00006
   LEWIS G, 1992, PSYCHOL MED, V22, P465, DOI 10.1017/S0033291700030415
   Liu C, 2011, HORM METAB RES, V43, P417, DOI 10.1055/s-0031-1275719
   Lo JC, 2005, KIDNEY INT, V67, P1047, DOI 10.1111/j.1523-1755.2005.00169.x
   Maratou E, 2009, EUR J ENDOCRINOL, V160, P785, DOI 10.1530/EJE-08-0797
   McLeod DSA, 2015, THYROID, V25, P621, DOI 10.1089/thy.2014.0504
   Ministerio da Saude. Departamento de Analise de Situac ao de Saude, 2011, 2010 SURV RISK PROT
   Nagasaki T, 2007, BIOMED PHARMACOTHER, V61, P482, DOI 10.1016/j.biopha.2007.04.004
   Nagasaki T, 2007, CLIN ENDOCRINOL, V66, P304, DOI 10.1111/j.1365-2265.2006.02730.x
   Nagasaki T, 2009, EUR J ENDOCRINOL, V160, P409, DOI 10.1530/EJE-08-0742
   Guimaraes JMN, 2009, J AFFECT DISORDERS, V117, P120, DOI 10.1016/j.jad.2008.12.012
   Olmos RD, 2015, BRAZ J MED BIOL RES, V48, P751, DOI [10.1590/1414-431X20154445, 10.1590/1414-431x20154445]
   Panicker V, 2009, CLIN ENDOCRINOL, V71, P574, DOI 10.1111/j.1365-2265.2008.03521.x
   Park YJ, 2011, EUR J ENDOCRINOL, V165, P115, DOI 10.1530/EJE-11-0014
   de Miranda EJFP, 2018, BRAZ J MED BIOL RES, V51, DOI [10.1590/1414-431X20187704, 10.1590/1414-431x20187704]
   de Miranda EJFP, 2018, BRAZ J MED BIOL RES, V51, DOI [10.1590/1414-431X20177196, 10.1590/1414-431x20177196]
   de Miranda ÉJFP, 2016, NUTR METAB CARDIOVAS, V26, P915, DOI 10.1016/j.numecd.2016.06.005
   Peixoto de Miranda ÉJF, 2017, CLIN ENDOCRINOL, V87, P597, DOI 10.1111/cen.13393
   de Miranda EJFP, 2017, AM J HYPERTENS, V30, P81, DOI 10.1093/ajh/hpw117
   de Miranda ÉJFP, 2016, EUR THYROID J, V5, P240, DOI 10.1159/000448683
   Petretta M, 2001, EUR J ENDOCRINOL, V145, P691, DOI 10.1530/eje.0.1450691
   Rhee CM, 2015, NEPHROL DIAL TRANSPL, V30, P282, DOI 10.1093/ndt/gfu303
   Santos IS, 2015, ARTERIOSCL THROM VAS, V35, P2054, DOI 10.1161/ATVBAHA.115.305765
   Santos IS, 2014, ATHEROSCLEROSIS, V237, P227, DOI 10.1016/j.atherosclerosis.2014.09.004
   Schmidt MI, 2015, INT J EPIDEMIOL, V44, P68, DOI 10.1093/ije/dyu027
   Schmidt MI, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-123
   Sichieri R, 2007, CLIN ENDOCRINOL, V66, P803, DOI 10.1111/j.1365-2265.2007.02816.x
   Silva N, 2014, EUR J ENDOCRINOL, V171, P327, DOI 10.1530/EJE-14-0031
   Singh BM, 2010, INDIAN J CLIN BIOCHE, V25, P141, DOI 10.1007/s12291-010-0026-x
   Stevens PE, 2013, ANN INTERN MED, V158, P825, DOI 10.7326/0003-4819-158-11-201306040-00007
   Szlejf C, 2018, PSYCHONEUROENDOCRINO, V87, P152, DOI 10.1016/j.psyneuen.2017.10.017
   Tan ZS, 2008, ARCH INTERN MED, V168, P1514, DOI 10.1001/archinte.168.14.1514
   Teixeira Patrícia de Fátima dos Santos, 2006, Rev. Assoc. Med. Bras., V52, P222
   Tükel R, 1999, PSYCHONEUROENDOCRINO, V24, P155, DOI 10.1016/S0306-4530(98)00067-5
   Tuzcu A, 2005, ENDOCR J, V52, P89, DOI 10.1507/endocrj.52.89
   Uzunlulu M, 2007, ENDOCR J, V54, P71, DOI 10.1507/endocrj.K06-124
   Volpato S, 2002, NEUROLOGY, V58, P1055, DOI 10.1212/WNL.58.7.1055
   Völzke H, 2004, J CLIN ENDOCR METAB, V89, P2145, DOI 10.1210/jc.2003-031028
   Wahlin Å, 2005, PSYCHONEUROENDOCRINO, V30, P625, DOI 10.1016/j.psyneuen.2005.01.010
   YERAGANI VK, 1987, CAN J PSYCHIAT, V32, P467, DOI 10.1177/070674378703200615
   Yu YT, 2013, ENDOCRINE, V44, P716, DOI 10.1007/s12020-013-9915-0
   Zhang YY, 2014, INT J EPIDEMIOL, V43, P1624, DOI 10.1093/ije/dyu126
   Zhang YY, 2014, ARTERIOSCL THROM VAS, V34, P2128, DOI 10.1161/ATVBAHA.114.303889
   Zhu LJ, 2014, CORONARY ARTERY DIS, V25, P427, DOI 10.1097/MCA.0000000000000095
NR 81
TC 2
Z9 2
U1 1
U2 7
PU ASSOC BRAS DIVULG CIENTIFICA
PI RIBEIRAO PRETO
PA FACULDADE MEDICINA, CASA 10, 14049 RIBEIRAO PRETO, RIBEIRAO PRETO, SP
   14049, BRAZIL
SN 0100-879X
EI 1678-4510
J9 BRAZ J MED BIOL RES
JI Brazilian J. Med. Biol. Res.
PY 2019
VL 52
IS 2
AR e8417
DI 10.1590/1414-431X20198417
PG 11
WC Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Life Sciences & Biomedicine - Other Topics; Research & Experimental
   Medicine
GA HM2DO
UT WOS:000459267400001
PM 30785482
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Du, LT
   Zhang, XL
   Wang, WB
   He, Q
   Li, T
   Chen, S
   Pan, Y
AF Du, Litao
   Zhang, Xianliang
   Wang, Wenbo
   He, Qiang
   Li, Ting
   Chen, Si
   Pan, Yang
TI Associations between objectively measured pattern of physical activity,
   sedentary behavior and fear of falling in Chinese community-dwelling
   older women
SO GERIATRIC NURSING
LA English
DT Article
DE Physical activity; Sedentary behavior; Mental health; Fear of falling;
   Community-dwelling older women
ID METABOLIC SYNDROME; RISK-FACTORS; PEOPLE; ADULTS; HEALTH; PERFORMANCE;
   INTENSITY; MORTALITY; MODERATE; OUTCOMES
AB This cross-sectional study aimed to examine the associations of objectively-measured physical activity (PA) and sedentary behavior (SB) patterns with fear of falling (FOF) in Chinese community-dwelling older women. Data from Physical Activity and Health in Older Women Study were analyzed for 1101 older women aged 60 to 70. Variables were demographics, objectively-measured PA, SB and FOF. Logistic regressions were conducted. All SB variables, light-intensity PA variable and bouted moderate-to-vigorous intensity PA (MVPA) were not associated with FOF. Total MVPA, sporadic MVPA and steps were independently associated with FOF. Multivariable-adjusted ORs in fully-adjusted models were 0.61, 0.59; 0.73, 0.62; 0.72, 0.59 for increasing tertiles of total MVPA time, sporadic MVPA time, and steps per day, respectively. The current finding which enables encourages PA in older women group could be complemented to maximize the overall level of potential public healthcare gains especially in community dwelling older population. (C) 2022 Elsevier Inc. All rights reserved.
C1 [Du, Litao; Zhang, Xianliang; He, Qiang; Li, Ting; Pan, Yang] Shandong Univ, Sch Phys Educ, 17922 Jingshi Rd, Jinan 250061, Shandong, Peoples R China.
   [Wang, Wenbo] Zaozhuang Vocat Coll Sci & Technol, Zaozhuang, Peoples R China.
   [Chen, Si] Shandong Univ, Cheeloo Coll Med, Sch Nursing & Rehabil, 44 West Wenhua Rd, Jinan 250102, Shandong, Peoples R China.
C3 Shandong University; Shandong University
RP Pan, Y (corresponding author), Shandong Univ, Sch Phys Educ, 17922 Jingshi Rd, Jinan 250061, Shandong, Peoples R China.; Chen, S (corresponding author), Shandong Univ, Cheeloo Coll Med, Sch Nursing & Rehabil, 44 West Wenhua Rd, Jinan 250102, Shandong, Peoples R China.
EM chensi@sdu.edu.cn; panyang@sdu.edu.cn
RI Du, Litao/IVU-6818-2023; Zhang, Xianliang/HTQ-1709-2023; Chen,
   Si/MGB-0660-2025
OI Chen, Si/0000-0002-6041-1528; Du, Litao/0000-0001-7296-7411; He,
   Qiang/0000-0002-7281-0200
FU Ministry of Education of Humanities and Social Science Project of China
   [19YJCZH255]; Fundamental Research Funds of Shandong University
   [2020GN064, 2020HW034]
FX This work was supported by the Ministry of Education of Humanities and
   Social Science Project of China under Grant 19YJCZH255; Fundamental
   Research Funds of Shandong University under Grant 2020GN064 and
   2020HW034.
CR Ballin M, 2021, SPORTS MED, V51, P339, DOI 10.1007/s40279-020-01356-y
   Bankoski A, 2011, DIABETES CARE, V34, P497, DOI 10.2337/dc10-0987
   Bootsman NJM, 2018, J SCI MED SPORT, V21, P173, DOI 10.1016/j.jsams.2017.07.006
   Choi L, 2011, MED SCI SPORT EXER, V43, P357, DOI 10.1249/MSS.0b013e3181ed61a3
   Clarke J, 2014, MED SCI SPORT EXER, V46, P76, DOI 10.1249/MSS.0b013e31829f83a0
   Denkinger MD, 2015, AM J GERIAT PSYCHIAT, V23, P72, DOI 10.1016/j.jagp.2014.03.002
   Ekelund U, 2020, BRIT J SPORT MED, V54, P1499, DOI 10.1136/bjsports-2020-103270
   Freedson PS, 1998, MED SCI SPORT EXER, V30, P777, DOI 10.1097/00005768-199805000-00021
   Gay JL, 2016, PREV MED, V86, P58, DOI 10.1016/j.ypmed.2016.01.008
   Gazibara T, 2017, PSYCHOGERIATRICS, V17, P215, DOI 10.1111/psyg.12217
   Giurgiu M, 2020, MED SCI SPORT EXER, V52, P457, DOI 10.1249/MSS.0000000000002132
   Guan Q., 2011, J TONGJI U MED SCI, V32, P81
   Hull SL, 2013, AM J GERIAT PSYCHIAT, V21, P1287, DOI 10.1016/j.jagp.2013.01.038
   Jackson S, 2018, DISABIL REHABIL, V40, P414, DOI 10.1080/09638288.2016.1258437
   Jakicic JM, 2019, MED SCI SPORT EXER, V51, P1213, DOI 10.1249/MSS.0000000000001933
   Jefferis BJ, 2016, INT J BEHAV NUTR PHY, V13, DOI 10.1186/s12966-016-0361-2
   Kehler DS, 2018, EXP GERONTOL, V104, P28, DOI 10.1016/j.exger.2018.01.014
   Khalil H, 2021, NEURODEGENER DIS MAN, V11, P113, DOI 10.2217/nmt-2020-0053
   Kim JH, 2020, ARCH GERONTOL GERIAT, V88, DOI 10.1016/j.archger.2020.104017
   Kim M, 2016, J EXERC REHABIL, V12, P489, DOI 10.12965/jer.1632716.358
   Kraus WE, 2019, MED SCI SPORT EXER, V51, P1206, DOI 10.1249/MSS.0000000000001932
   Lavedán A, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194967
   Lee IM, 2019, JAMA INTERN MED, V179, P1105, DOI 10.1001/jamainternmed.2019.0899
   Lee PH, 2013, J SCI MED SPORT, V16, P227, DOI 10.1016/j.jsams.2012.10.005
   Loprinzi PD, 2013, AM J HEALTH PROMOT, V27, P143, DOI 10.4278/ajhp.110916-QUAN-348
   de Rezende LFM, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-333
   Monteiro AM, 2021, J WOMEN AGING, V33, P57, DOI 10.1080/08952841.2019.1681244
   Murphy SL, 2003, J GERONTOL A-BIOL, V58, P943
   Myers AM, 1998, J GERONTOL A-BIOL, V53, pM287, DOI 10.1093/gerona/53A.4.M287
   Patterson R, 2018, EUR J EPIDEMIOL, V33, P811, DOI 10.1007/s10654-018-0380-1
   Qin Y, 2021, NURS HEALTH SCI, V23, P516, DOI 10.1111/nhs.12840
   Ren PF, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19052938
   Rosenberg DE, 2016, J GERONTOL A-BIOL, V71, P78, DOI 10.1093/gerona/glv103
   Rosic Gilly, 2019, BMC Obes, V6, P7, DOI 10.1186/s40608-019-0230-z
   Saint-Maurice PF, 2020, JAMA-J AM MED ASSOC, V323, P1151, DOI 10.1001/jama.2020.1382
   Sawa R, 2020, J GERONTOL B-PSYCHOL, V75, P953, DOI 10.1093/geronb/gby103
   Scheffer AC, 2008, AGE AGEING, V37, P19, DOI 10.1093/ageing/afm169
   Stamatakis E, 2019, BRIT J SPORT MED, V53, P1381, DOI 10.1136/bjsports-2018-100468
   Su QQ, 2021, FRONT PUBLIC HEALTH, V9, DOI 10.3389/fpubh.2021.766959
   Sun F, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-449
   TINETTI ME, 1990, J GERONTOL, V45, pP239, DOI 10.1093/geronj/45.6.P239
   Whipple MO, 2019, J VASC NURS, V37, P91, DOI 10.1016/j.jvn.2019.02.001
   Wolff-Hughes DL, 2015, J PHYS ACT HEALTH, V12, P694, DOI 10.1123/jpah.2013-0463
   World Health Organizatin, 2020, WHO guidelines on physical activity and sedentary behaviour
NR 44
TC 7
Z9 8
U1 8
U2 55
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0197-4572
EI 1528-3984
J9 GERIATR NURS
JI Geriatr. Nurs.
PD JUL-AUG
PY 2022
VL 46
BP 80
EP 85
DI 10.1016/j.gerinurse.2022.05.001
EA MAY 2022
PG 6
WC Geriatrics & Gerontology; Gerontology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Nursing
GA 3F8EU
UT WOS:000830896300012
PM 35613487
DA 2025-06-11
ER

PT J
AU Puchau, B
   Zulet, MA
   de Echávarri, AG
   Navarro-Blasco, I
   Martínez, JA
AF Puchau, B.
   Zulet, M. A.
   Gonzalez de Echavarri, A.
   Navarro-Blasco, I.
   Martinez, J. A.
TI Selenium intake reduces serum C3, an early marker of metabolic syndrome
   manifestations, in healthy young adults
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE inflammation; complement factor 3; oxidative stress; antioxidant;
   selenium; metabolic syndrome
ID ACYLATION-STIMULATING PROTEIN; POPULATION-BASED COHORT; TO-HEIGHT RATIO;
   INSULIN-RESISTANCE; COMPLEMENT C3; RISK-FACTOR; REACTIVE PROTEIN;
   ADIPOSE-TISSUE; PLASMA-LEVELS; MEN
AB Objectives: To evaluate the associations between serum complement factor 3 (C3) and several anthropometrical, biochemical and lifestyle features in healthy young adults, emphasizing on the putative effect of selenium intake on C3 concentrations.
   Methods: This study enrolled 100 healthy young adults aged 18-34 years. Anthropometric and blood pressure measurements and lifestyle features were analyzed. Fasting blood samples were collected for the measurement of glucose, total cholesterol, HDL-cholesterol, LDL-cholesterol, triacylglycerols and C3 concentrations. Nail samples were collected for the analysis of selenium concentrations.
   Results: Values of BMI (P = 0.034), sum of skinfold thicknesses (STs) (P = 0.021), body fat mass (BFM) (P = 0.023), percentage of overweight subjects (P = 0.007), serum triacylglycerols (P = 0.012) and nail selenium (P = 0.001) were significantly different between subjects above and below the median of serum C3 concentrations. The following correlations with serum C3 were identified tricipital ST (P = 0.033), sum of STs (P = 0.012), BMI (P = 0.008), BFM (P = 0.018), waist-to-height ratio (P = 0.016), serum glucose (P = 0.045), serum triacylglycerols (P = 0.001) and nail selenium (P = 0.006). Circulating C3 showed a positive association with several adiposity markers such as BMI (P = 0.001), waist circumference (P = 0.006), waist-to-height ratio (P = 0.002), BFM (P = 0.025), as well as serum glucose (P = 0.027) and triacylglycerols (P < 0.001), whereas nail selenium was a statistically significant negative predictor of C3 concentrations (P = 0.018).
   Conclusions: C3 seems to be related with selenium status and several anthropometrical and biochemical measurements linked to metabolic syndrome in apparently healthy young adults. These findings suggest a possible role for selenium intake in the modulation of C3, whose assessment may be an early marker of metabolic syndrome manifestations. European Journal of Clinical Nutrition (2009) 63, 858-864; doi:10.1038/ejcn.2008.48; published online 5 November 2008
C1 [Puchau, B.; Zulet, M. A.; Gonzalez de Echavarri, A.; Martinez, J. A.] Univ Navarra, Dept Nutr & Food Sci Physiol & Toxicol, Pamplona 31008, Spain.
   [Navarro-Blasco, I.] Univ Navarra, Dept Chem & Soil Sci, Pamplona 31008, Spain.
C3 University of Navarra; University of Navarra
RP Martínez, JA (corresponding author), Univ Navarra, Dept Nutr & Food Sci Physiol & Toxicol, Calle Irunlarrea 1, Pamplona 31008, Spain.
EM jalfmtz@unav.es
RI Martinez Hernandez, J Alfredo/K-8709-2014; Navarro-Blasco,
   Inigo/D-8148-2012; Zulet, M. Angeles/H-1317-2017
OI Martinez Hernandez, J Alfredo/0000-0001-5218-6941; Navarro-Blasco,
   Inigo/0000-0003-1863-0580; Zulet, M. Angeles/0000-0002-3926-0892
FU Linea Especial about Nutrition; Obesity and Health (LE/97); Health
   Department of the Government of Navarra(22/2007); University of Navarra
FX This study is supported by the Linea Especial about Nutrition, Obesity
   and Health (LE/97), the Health Department of the Government of
   Navarra(22/2007) and the ADA fellowships scheme of the University of
   Navarra. We thank Veronica Ciaurriz and Ana Lorente for technical
   assistance, Blanca Martinez de Morentin and Salome Perez for assistance
   with the data collection and all those who volunteered to participate in
   the study.
CR Barnum S R, 1989, Year Immunol, V6, P208
   BENATAR SR, 2004, WORLD MED J, V50, P11
   Bleys J, 2008, AM J CLIN NUTR, V88, P416
   Brenneisen Peter, 2005, Molecular Aspects of Medicine, V26, P256, DOI 10.1016/j.mam.2005.07.004
   Bykov I, 2006, ANN MED, V38, P280, DOI 10.1080/07853890600664608
   CHOY LN, 1992, J BIOL CHEM, V267, P12736
   Cianflone K, 2003, BBA-BIOMEMBRANES, V1609, P127, DOI 10.1016/S0005-2736(02)00686-7
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   Dandona P, 2004, TRENDS IMMUNOL, V25, P4, DOI 10.1016/j.it.2003.10.013
   Engström G, 2005, DIABETOLOGIA, V48, P2525, DOI 10.1007/s00125-005-0021-6
   Engström G, 2005, DIABETES, V54, P570, DOI 10.2337/diabetes.54.2.570
   Ferencík M, 2003, FOLIA MICROBIOL, V48, P417, DOI 10.1007/BF02931378
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Fulop T, 2006, PATHOL BIOL, V54, P375, DOI 10.1016/j.patbio.2006.07.002
   Gabrielsson BG, 2003, OBES RES, V11, P699, DOI 10.1038/oby.2003.100
   Ghayour-Mobarhan M, 2005, ANN CLIN BIOCHEM, V42, P364, DOI 10.1258/0004563054889990
   Gibson Rosalind S., 2005, Principles of Nutritional Assessment
   Halkes CJM, 2001, ARTERIOSCL THROM VAS, V21, P1526, DOI 10.1161/hq0901.095276
   Hsieh SD, 2005, PREV MED, V40, P216, DOI 10.1016/j.ypmed.2004.05.025
   Hsieh SD, 2003, INT J OBESITY, V27, P610, DOI 10.1038/sj.ijo.0802259
   HUNTER DJ, 1990, AM J EPIDEMIOL, V132, P114, DOI 10.1093/oxfordjournals.aje.a115623
   Koistinen HA, 2001, ARTERIOSCL THROM VAS, V21, P1034, DOI 10.1161/01.ATV.21.6.1034
   Kriketos AD, 2004, DIABETES CARE, V27, P2033, DOI 10.2337/diacare.27.8.2033
   Maehira F, 2002, CLIN CHIM ACTA, V316, P137, DOI 10.1016/S0009-8981(01)00744-6
   Maslowska M, 1999, EUR J CLIN INVEST, V29, P679, DOI 10.1046/j.1365-2362.1999.00514.x
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Moreno-Aliaga MJ., 2005, Adipocytes, V1, P1
   Muscari A, 2005, INT J CARDIOL, V100, P217, DOI 10.1016/j.ijcard.2004.07.024
   Musil F, 2005, NUTRITION, V21, P118, DOI 10.1016/j.nut.2004.07.003
   Onat A, 2005, CLIN SCI, V108, P129, DOI 10.1042/CS20040198
   Sahu A, 2001, IMMUNOL REV, V180, P35, DOI 10.1034/j.1600-065X.2001.1800103.x
   Sampietro T, 2004, HEART, V90, P1438, DOI 10.1136/hrt.2003.017327
   Satia JA, 2006, ANN EPIDEMIOL, V16, P53, DOI 10.1016/j.annepidem.2005.02.011
   Savoia C, 2007, CLIN SCI, V112, P375, DOI 10.1042/CS20060247
   Scheurig AC, 2008, EUR J CLIN NUTR, V62, P127, DOI 10.1038/sj.ejcn.1602687
   Sniderman AD, 2000, CURR OPIN LIPIDOL, V11, P291, DOI 10.1097/00041433-200006000-00010
   van Oostrom AJHHM, 2007, ATHEROSCLEROSIS, V190, P167, DOI 10.1016/j.atherosclerosis.2006.01.009
   Vincent HK, 2006, INT J OBESITY, V30, P400, DOI 10.1038/sj.ijo.0803177
   Wärnberg J, 2006, AM J CLIN NUTR, V84, P505
   Ylitalo K, 2001, ARTERIOSCL THROM VAS, V21, P838, DOI 10.1161/01.ATV.21.5.838
   Yudkin JS, 2000, EUR HEART J, V21, P1036, DOI 10.1053/euhj.2000.2118
NR 41
TC 44
Z9 46
U1 0
U2 3
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0954-3007
EI 1476-5640
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD JUL
PY 2009
VL 63
IS 7
BP 858
EP 864
DI 10.1038/ejcn.2008.48
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 464MX
UT WOS:000267510300007
PM 18985060
DA 2025-06-11
ER

PT J
AU Sugawara, N
   Yasui-Furukori, N
   Yamazaki, M
   Shimoda, K
   Mori, T
   Sugai, T
   Matsuda, H
   Suzuki, Y
   Ozeki, Y
   Okamoto, K
   Sagae, T
   Someya, T
AF Sugawara, Norio
   Yasui-Furukori, Norio
   Yamazaki, Manabu
   Shimoda, Kazutaka
   Mori, Takao
   Sugai, Takuro
   Matsuda, Hiroshi
   Suzuki, Yutaro
   Ozeki, Yuji
   Okamoto, Kurefu
   Sagae, Toyoaki
   Someya, Toshiyuki
TI Predictive Utility of Body Mass Index for Metabolic Syndrome Among
   Patients with Schizophrenia in Japan
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Article
DE body mass index; metabolic syndrome; schizoaffective disorder;
   schizophrenia
ID WAIST CIRCUMFERENCE; LIKELIHOOD RATIOS; MORTALITY; ABNORMALITIES;
   PREVALENCE; ANTIPSYCHOTICS; DYSREGULATION; DEPRESSION; NATIONWIDE;
   DISEASE
AB Background: Reliable and easy screening for metabolic syndrome (MetS) is important for patients with schizophrenia. The aim of this study was to assess the predictive utility of body mass index (BMI) for MetS among patients with schizophrenia in Japan.
   Methods: In total, 8468 patients (4705 males, 3763 females) with schizophrenia or schizoaffective disorders based on the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV), or the International Classification of Diseases, tenth revision (ICD-10), were assessed for MetS using the criteria of the National Cholesterol Education Program Adult Treatment Panel III (ATP III-A). We applied a stratum-specific likelihood ratio (SSLR) analysis, which is independent of the prevalence of the target disease.
   Results: The mean (+/- standard deviation) age of these patients was 57.4 +/- 13.5 years. The prevalence of MetS was 20.4%. Among males, the SSLRs predicting MetS were 0.03 (95% CI 0.02-0.06), 0.54 (95% CI 0.48-0.60), 2.77 (95% CI 2.44-3.14) and 8.75 (95% CI 7.40-10.36) for BMI <20 kg/m(2), 20 kg/m(2) <= BMI < 25 kg/m(2), 25 kg/m(2)<= BMI < 28 kg/ m(2), and 28 kg/m(2), and 28 kg/m(2)<= BMI, respectively. For females, the SSLRs predicting MetS were 0.08 (95% CI 0.05-0.12), 0.73 (95% CI 0.66-0.82), 2.50 (95% CI 2.16-2.90) and 4.83 (95% CI 4.12-5.67) for the same BMI categories, respectively.
   Conclusion: The predictive utility of BMI is confirmed, and BMI has more predictive value in males than in females. Patients with a BMI of 28 kg/m(2) or greater had a significantly higher SSLR than those with a BMI less than 28 kg/m(2).
C1 [Sugawara, Norio; Yasui-Furukori, Norio; Shimoda, Kazutaka] Dokkyo Med Univ, Dept Psychiat, Sch Med, 880 Kitakobayashi, Mibu, Tochigi 3210293, Japan.
   [Sugawara, Norio; Yasui-Furukori, Norio; Shimoda, Kazutaka; Sugai, Takuro; Suzuki, Yutaro; Ozeki, Yuji; Someya, Toshiyuki] Japanese Soc Clin Neuropsychopharmacol, Chiyoda Ku, Tokyo 1010003, Japan.
   [Yamazaki, Manabu; Mori, Takao; Matsuda, Hiroshi; Okamoto, Kurefu; Sagae, Toyoaki] Japan Psychiat Hosp Assoc, Minato Ku, Tokyo 1088554, Japan.
   [Sugai, Takuro; Suzuki, Yutaro; Someya, Toshiyuki] Niigata Univ, Grad Sch Med & Dent Sci, Dept Psychiat, Chuo Ku, Niigata 9518510, Japan.
   [Ozeki, Yuji] Shiga Univ Med Sci, Dept Psychiat, Otsu, Shiga 5202134, Japan.
   [Sagae, Toyoaki] Yamagata Prefectural Yonezawa Univ Nutr Sci, Dept Hlth & Nutr, Yonezawa, Yamagata 9920025, Japan.
C3 Dokkyo Medical University; Niigata University; Shiga University of
   Medical Science
RP Sugawara, N (corresponding author), Dokkyo Med Univ, Dept Psychiat, Sch Med, 880 Kitakobayashi, Mibu, Tochigi 3210293, Japan.
EM nsuga3@dokkyomed.ac.jp
RI Someya, Toshiyuki/ABD-1878-2021
OI Sugawara, Norio/0000-0001-7058-664X
FU Eisai Co., Ltd.; Yoshitomi Pharmaceutical Industries; Dainippon Sumitomo
   Pharma Co., Ltd.; Astellas Pharma Inc.; Meiji Seika Pharma Co., Ltd.;
   Eli Lilly Japan K.K.; Otsuka Pharmaceutical Co., Ltd.; GlaxoSmithKline
   K.K.; Janssen Pharmaceutical K.K.; MSD K.K.; Shionogi Co., Ltd.; Ono
   Pharmaceutical Co., Ltd.; Tsumura Co.; Asahi Kasei Pharma Corp.;
   Novartis Pharma Co., Ltd.; Takeda Pharmaceutical Co., Ltd.;
   Grants-in-Aid for Scientific Research [20H03597] Funding Source: KAKEN
FX This work was partially supported by Eisai Co., Ltd.; Yoshitomi
   Pharmaceutical Industries; Dainippon Sumitomo Pharma Co., Ltd.; Astellas
   Pharma Inc.; Meiji Seika Pharma Co., Ltd.; Eli Lilly Japan K.K.; Otsuka
   Pharmaceutical Co., Ltd.; GlaxoSmithKline K.K.; Janssen Pharmaceutical
   K.K.; MSD K.K.; Shionogi & Co., Ltd.; Asahi Kasei Pharma Corp.; Novartis
   Pharma Co., Ltd.; Takeda Pharmaceutical Co., Ltd.; Ono Pharmaceutical
   Co., Ltd.; and Tsumura & Co. The funders had no role in the study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
CR Brown S, 2010, BRIT J PSYCHIAT, V196, P116, DOI 10.1192/bjp.bp.109.067512
   Caemmerer J, 2012, SCHIZOPHR RES, V140, P159, DOI 10.1016/j.schres.2012.03.017
   Dipasquale S, 2013, J PSYCHIATR RES, V47, P197, DOI 10.1016/j.jpsychires.2012.10.005
   Foley DL, 2011, ARCH GEN PSYCHIAT, V68, P609, DOI 10.1001/archgenpsychiatry.2011.2
   Grundy SM, 1999, AM J CARDIOL, V83, p25F
   Hiuge-Shimizu A, 2012, ANN MED, V44, P82, DOI 10.3109/07853890.2010.526138
   Hjorthoj C, 2017, LANCET PSYCHIAT, V4, P295, DOI 10.1016/S2215-0366(17)30078-0
   Inada T, 2015, PSYCHIAT CLIN NEUROS, V69, P440, DOI 10.1111/pcn.12275
   Katon W, 2008, AMBUL PEDIATR, V8, P182, DOI 10.1016/j.ambp.2008.01.003
   Kawada T, 2011, DIABETES METAB SYND, V5, P25, DOI 10.1016/j.dsx.2010.05.012
   Matsuzawa Y, 2002, CIRC J, V66, P987, DOI 10.1253/circj.66.987
   McGee S, 2002, J GEN INTERN MED, V17, P646
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P295, DOI 10.1093/schbul/sbs082
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Mukundan A, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006629.pub2
   Nielsen RE, 2013, SCHIZOPHR RES, V146, P22, DOI 10.1016/j.schres.2013.02.025
   Nurjono M, 2013, EARLY INTERV PSYCHIA, V7, P205, DOI 10.1111/j.1751-7893.2012.00384.x
   Olfson M, 2015, JAMA PSYCHIAT, V72, P1172, DOI 10.1001/jamapsychiatry.2015.1737
   Paley CA, 2018, BMC SPORTS SCI MED R, V10, DOI 10.1186/s13102-018-0097-1
   PEIRCE JC, 1993, MED DECIS MAKING, V13, P141, DOI 10.1177/0272989X9301300208
   Pillinger T, 2020, LANCET PSYCHIAT, V7, P64, DOI 10.1016/S2215-0366(19)30416-X
   Rui Q, 2014, PROG NEURO-PSYCHOPH, V53, P45, DOI 10.1016/j.pnpbp.2014.02.007
   Schmitz N, 2000, SOC PSYCH PSYCH EPID, V35, P375, DOI 10.1007/s001270050253
   Sicras-Mainar A, 2015, NEUROPSYCH DIS TREAT, V11, P51, DOI 10.2147/NDT.S75449
   Sugai T, 2016, SCHIZOPHR RES, V171, P68, DOI 10.1016/j.schres.2016.01.016
   Sugai T, 2012, J CLIN PSYCHOPHARM, V32, P390, DOI 10.1097/JCP.0b013e3182524393
   SUGAWARA N, 2012, ANN GEN PSYCHIATR, V11, DOI DOI 10.1186/1744-859X-11-1120
   Sugawara N, 2018, J PSYCHIATR RES, V97, P77, DOI 10.1016/j.jpsychires.2017.12.002
   Sugawara N, 2017, NEUROPSYCH DIS TREAT, V13, P2369, DOI 10.2147/NDT.S142517
   Sugawara N, 2016, NEUROPSYCH DIS TREAT, V12, P427, DOI 10.2147/NDT.S98711
   Sugawara N, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/1471-244X-14-184
   Sugawara N, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0086826
   Sugawara N, 2010, SCHIZOPHR RES, V123, P244, DOI 10.1016/j.schres.2010.08.030
   Tirupati S, 2007, AUSTRALAS PSYCHIATRY, V15, P470, DOI 10.1080/10398560701636906
   Vancampfort D, 2013, PSYCHIAT RES, V207, P25, DOI 10.1016/j.psychres.2012.09.026
   Venables W.N., 2016, An Introduction to R - Notes on R: A Programming Environment for Data Analysis and Graphics
   Walker ER, 2015, JAMA PSYCHIAT, V72, P334, DOI 10.1001/jamapsychiatry.2014.2502
   Yasui-Furukori N, 2002, PROG NEURO-PSYCHOPH, V26, P53, DOI 10.1016/S0278-5846(01)00218-4
   Yasui-Furukori N, 2009, J CLIN PSYCHIAT, V70, P95, DOI 10.4088/JCP.07m03829
NR 40
TC 7
Z9 7
U1 0
U2 2
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2020
VL 16
BP 2229
EP 2236
DI 10.2147/NDT.S269619
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA NY8ZT
UT WOS:000576673900002
PM 33061393
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Shaw, J
   Anderson, T
AF Shaw, Jeffrey
   Anderson, Todd
TI Coronary endothelial dysfunction in non-obstructive coronary artery
   disease: Risk, pathogenesis, diagnosis and therapy
SO VASCULAR MEDICINE
LA English
DT Review
DE Cardiac syndrome X; chest pain syndromes; coronary artery disease;
   endothelial dysfunction; microvascular angina; NoCAD
ID CARDIAC SYNDROME-X; ISCHEMIA SYNDROME EVALUATION; SYNDROME EVALUATION
   WISE; CONVERTING ENZYME-INHIBITION; STABLE ANGINA-PECTORIS;
   CARDIOVASCULAR MAGNETIC-RESONANCE; INDUCED MYOCARDIAL-ISCHEMIA;
   LEFT-VENTRICULAR FUNCTION; EXERCISE-INDUCED ANGINA; ST SEGMENT
   DEPRESSION
AB Up to half of patients with signs and symptoms of stable ischemic heart disease have non-obstructive coronary artery disease (NoCAD). Recent evidence demonstrates that two-thirds of patients with NoCAD have demonstrable coronary endothelial dysfunction represented by microvascular or diffuse epicardial spasm following acetylcholine challenge. Patients with coronary endothelial dysfunction are recognized to have significant health services use and morbidity as well as increased risk of developing flow-limiting coronary artery disease and myocardial events, including death. Currently, there are few centers that test for this etiology owing to lack of knowledge, limited evidence for treatment options and invasive diagnostic strategies. This article reviews the pathophysiology, epidemiology, diagnosis and treatment of coronary endothelial dysfunction as a subgroup of NoCAD.
C1 [Shaw, Jeffrey; Anderson, Todd] Univ Calgary, Fac Med, Hlth Sci Ctr, Dept Cardiac Sci, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.
C3 University of Calgary; University Calgary Hospital
RP Shaw, J (corresponding author), Univ Calgary, Fac Med, Hlth Sci Ctr, Dept Cardiac Sci, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.
EM jashaw@ucalgary.ca
CR AIZAWA T, 1989, AM J CARDIOL, V63, pJ75, DOI 10.1016/0002-9149(89)90210-5
   Al Suwaidi J, 2000, CIRCULATION, V101, P948, DOI 10.1161/01.CIR.101.9.948
   Albertsson PA, 1996, INT J CARDIOL, V54, P13, DOI 10.1016/0167-5273(96)02560-0
   ANDERSON TJ, 1995, J AM COLL CARDIOL, V26, P1235, DOI 10.1016/0735-1097(95)00327-4
   Anderson TJ, 2011, CIRCULATION, V123, P163, DOI 10.1161/CIRCULATIONAHA.110.953653
   Arthur HM, 2012, CAN J CARDIOL, V28, pS42, DOI 10.1016/j.cjca.2011.09.006
   Avogaro A, 2005, CLIN CHIM ACTA, V360, P9, DOI 10.1016/j.cccn.2005.04.020
   Bavry AA, 2014, AM HEART J, V167, P826, DOI 10.1016/j.ahj.2014.01.017
   Bisoendial RJ, 2003, CIRCULATION, V107, P2944, DOI 10.1161/01.CIR.0000070934.69310.1A
   Bugiardini R, 2005, JAMA-J AM MED ASSOC, V293, P477, DOI 10.1001/jama.293.4.477
   Bugiardini R, 2004, CIRCULATION, V109, P2518, DOI 10.1161/01.CIR.0000128208.22378.E3
   BUGIARDINI R, 1989, AM J CARDIOL, V63, P286, DOI 10.1016/0002-9149(89)90332-9
   Chen JW, 2002, AM J CARDIOL, V90, P974, DOI 10.1016/S0002-9149(02)02664-4
   Chen JW, 1997, AM J CARDIOL, V80, P32
   Cosín-Sales J, 2003, J AM COLL CARDIOL, V41, P1468, DOI 10.1016/S0735-1097(03)00243-2
   Crea F, 2013, CHEST PAIN NORMAL CO, P189
   Dart A M, 1980, Eur Heart J, V1, P97
   Di Franco A, 2014, EUR REV MED PHARMACO, V18, P374
   Di Franco A, 2011, EUR HEART J, V32, P569
   Dick GM, 2010, EXP BIOL MED, V235, P10, DOI 10.1258/ebm.2009.009201
   Egashira K, 1996, CIRCULATION, V94, P130, DOI 10.1161/01.CIR.94.2.130
   EPSTEIN SE, 1986, J AM COLL CARDIOL, V8, P459, DOI 10.1016/S0735-1097(86)80067-5
   Fábián E, 2004, AM J CARDIOL, V94, P652, DOI 10.1016/j.amjcard.2004.05.035
   Fihn SD, 2012, J AM COLL CARDIOL, V60, pE44, DOI 10.1016/j.jacc.2012.07.013
   Fox K, 2006, EUR HEART J, V27, P1341, DOI 10.1093/eurheartj/ehl001
   Fragasso G, 1997, HEART, V77, P32, DOI 10.1136/hrt.77.1.32
   FUH MMT, 1993, METABOLISM, V42, P1090, DOI 10.1016/0026-0495(93)90264-O
   Galiuto L, 2007, AM J CARDIOL, V99, P1378, DOI 10.1016/j.amjcard.2006.12.070
   Halcox JPJ, 2002, CIRCULATION, V106, P653, DOI 10.1161/01.CIR.0000025404.78001.D8
   Hasdai D, 1999, HERZ, V24, P544, DOI 10.1007/BF03044226
   Hayward CS, 2000, CARDIOVASC RES, V46, P28, DOI 10.1016/S0008-6363(00)00005-5
   Hoffmann E, 1998, AM HEART J, V135, P684, DOI 10.1016/S0002-8703(98)70286-8
   HONGO M, 1995, AM J CARDIOL, V75, P246, DOI 10.1016/0002-9149(95)80029-R
   Jespersen L, 2012, EUR HEART J, V33, P734, DOI 10.1093/eurheartj/ehr331
   Jhund PS, 2001, J AM COLL CARDIOL, V37, P1367, DOI 10.1016/S0735-1097(01)01168-8
   Johnson BD, 2006, EUR HEART J, V27, P1408, DOI 10.1093/eurheartj/ehl040
   Johnson BD, 2004, CIRCULATION, V109, P2993, DOI 10.1161/01.CIR.0000130642.79868.B2
   Johnston N, 2011, EUR HEART J, V32, P1331, DOI 10.1093/eurheartj/ehr009
   Joye James D., 1997, Cardiology Clinics, V15, P101, DOI 10.1016/S0733-8651(05)70321-0
   Kaski JC, 2006, HEART, V92, P5, DOI 10.1136/hrt.2005.070318
   KASKI JC, 1995, J AM COLL CARDIOL, V25, P807, DOI 10.1016/0735-1097(94)00507-M
   KASKI JC, 1995, BRIT HEART J, V74, P620
   KASKI JC, 1994, J AM COLL CARDIOL, V23, P652, DOI 10.1016/0735-1097(94)90750-1
   Kaski JC, 1998, AM HEART J, V136, P412, DOI 10.1016/S0002-8703(98)70214-5
   Kaufmann PA, 2000, CIRCULATION, V102, P1233, DOI 10.1161/01.CIR.102.11.1233
   Kaufmann PA, 2005, J NUCL MED, V46, P75
   Kayikcioglu M, 2003, EUR HEART J, V24, P1999, DOI 10.1016/S0195-668X(03)00478-0
   KEMP HG, 1986, J AM COLL CARDIOL, V7, P479, DOI 10.1016/S0735-1097(86)80456-9
   KEMP HG, 1973, AM J CARDIOL, V32, P375, DOI 10.1016/S0002-9149(73)80150-X
   Kolasinska-Kloch W, 2002, SCAND J CLIN LAB INV, V62, P7, DOI 10.1080/003655102753517145
   Lamendola P, 2010, INT J CARDIOL, V140, P197, DOI 10.1016/j.ijcard.2008.11.026
   Landmesser U, 2007, CURR OPIN CARDIOL, V22, P316, DOI 10.1097/HCO.0b013e3281ca710d
   LANZA GA, 1994, CIRCULATION, V90, P2695, DOI 10.1161/01.CIR.90.6.2695
   Lanza GA, 1999, AM J CARDIOL, V84, P1187, DOI 10.1016/S0002-9149(99)00532-9
   Lanza GA, 1999, AM J CARDIOL, V84, P854, DOI 10.1016/S0002-9149(99)00450-6
   Lanza GA, 2013, CHEST PAIN NORMAL CO, P65
   Lanza GA, 2008, J AM COLL CARDIOL, V51, P466, DOI 10.1016/j.jacc.2007.08.060
   Lanza GA, 2010, CIRCULATION, V121, P2317, DOI 10.1161/CIRCULATIONAHA.109.900191
   Leonardo F, 1999, Cardiologia, V44, P1065
   LICHTLEN PR, 1995, J AM COLL CARDIOL, V25, P1013, DOI 10.1016/0735-1097(94)00519-V
   Lin FY, 2011, J AM COLL CARDIOL, V58, P510, DOI 10.1016/j.jacc.2010.11.078
   MASERI A, 1995, ISCHEMIC HEART DIS R, P71
   Matsuzawa Y, 2010, J AM COLL CARDIOL, V55, P1688, DOI 10.1016/j.jacc.2009.10.073
   Meimoun P, 2008, EUR J ECHOCARDIOGR, V9, P449, DOI 10.1093/ejechocard/jen004
   Metz CNB, 2006, J AM COLL CARDIOL, V47, p21S, DOI 10.1016/j.jacc.2004.12.084
   Mohri M, 2003, J AM COLL CARDIOL, V41, P15, DOI 10.1016/S0735-1097(02)02632-3
   Mohri M, 1998, LANCET, V351, P1165, DOI 10.1016/S0140-6736(97)07329-7
   MONTORSI P, 1990, AM J CARDIOL, V66, P302, DOI 10.1016/0002-9149(90)90840-W
   MUKERJI V, 1993, TEX HEART I J, V20, P170
   NABEL EG, 1988, CIRCULATION, V77, P43, DOI 10.1161/01.CIR.77.1.43
   Ninomiya Y, 2008, HEART VESSELS, V23, P83, DOI 10.1007/s00380-007-1019-4
   Nitenberg A, 2004, DIABETES CARE, V27, P208, DOI 10.2337/diacare.27.1.208
   Ogawa H, 2010, CIRC J, V74, P1745, DOI 10.1253/circj.CJ-10-74-0802
   Ohba K, 2012, J AM HEART ASSOC, V1, DOI 10.1161/JAHA.112.002485
   OKUMURA K, 1988, J AM COLL CARDIOL, V12, P883, DOI 10.1016/0735-1097(88)90449-4
   Ong P, 2013, CHEST PAIN NORMAL CO, P243
   Ong P, 2008, J AM COLL CARDIOL, V52, P523, DOI 10.1016/j.jacc.2008.04.050
   Ong P, 2013, HEART, V99, P1288, DOI 10.1136/heartjnl-2012-302042
   Ong P, 2012, CLIN RES CARDIOL, V101, P673, DOI 10.1007/s00392-012-0442-4
   Ong P, 2012, CARDIOVASC DRUG THER, V26, P239, DOI 10.1007/s10557-012-6382-4
   Ong P, 2012, J AM COLL CARDIOL, V59, pE1487, DOI 10.1016/S0735-1097(12)61488-0
   Ong P, 2012, J AM COLL CARDIOL, V59, P655, DOI 10.1016/j.jacc.2011.11.015
   Özçelik F, 1999, CLIN CARDIOL, V22, P361
   Panting JR, 2002, NEW ENGL J MED, V346, P1948, DOI 10.1056/NEJMoa012369
   PAPANICOLAOU MN, 1986, AM J CARDIOL, V58, P1181, DOI 10.1016/0002-9149(86)90378-4
   PASTERNAK RC, 1980, AM J MED, V68, P813, DOI 10.1016/0002-9343(80)90199-0
   Patel MR, 2010, NEW ENGL J MED, V363, P498
   Pauly DF, 2011, AM HEART J, V162, P678, DOI 10.1016/j.ahj.2011.07.011
   PROUDFIT WL, 1966, CIRCULATION, V33, P901, DOI 10.1161/01.CIR.33.6.901
   Radice M, 1996, AM J CARDIOL, V78, P88, DOI 10.1016/S0002-9149(96)00231-7
   ROMEO F, 1988, AM J CARDIOL, V62, P312, DOI 10.1016/0002-9149(88)90232-9
   Roqué M, 1998, J AM COLL CARDIOL, V31, P139, DOI 10.1016/S0735-1097(97)00436-1
   Rosamond W, 2008, CIRCULATION, V117, pE25, DOI 10.1161/CIRCULATIONAHA.107.187998
   Rosano GMC, 1996, J AM COLL CARDIOL, V28, P1500
   RUBANYI GM, 1994, PHARMACOL REV, V46, P325
   Schächinger V, 2000, CIRCULATION, V101, P1899, DOI 10.1161/01.CIR.101.16.1899
   Schindler TH, 2003, J AM COLL CARDIOL, V42, P814, DOI 10.1016/S0735-1097(03)00851-9
   Sestito A, 2011, J CARDIOVASC MED, V12, P322, DOI 10.2459/JCM.0b013e3283406479
   Shaw LJ, 2008, CIRCULATION, V117, P1787, DOI 10.1161/CIRCULATIONAHA.107.726562
   Shaw LJ, 2006, CIRCULATION, V114, P894, DOI 10.1161/CIRCULATIONAHA.105.609990
   Shimbo D, 2007, ATHEROSCLEROSIS, V192, P197, DOI 10.1016/j.atherosclerosis.2006.05.005
   Sun HT, 2002, J AM COLL CARDIOL, V39, P847, DOI 10.1016/S0735-1097(02)01690-X
   Takase B, 1998, AM J CARDIOL, V82, P1535, DOI 10.1016/S0002-9149(98)00702-4
   Tanguay JF, 2003, J AM COLL CARDIOL, V41, p404A
   Vakkilainen J, 2000, CIRCULATION, V102, P716, DOI 10.1161/01.CIR.102.7.716
   VANE JR, 1990, NEW ENGL J MED, V323, P27
   Villano A, 2013, AM J CARDIOL, V112, P8, DOI 10.1016/j.amjcard.2013.02.045
   von Mering GO, 2004, CIRCULATION, V109, P722, DOI 10.1161/01.CIR.0000115525.92645.16
   Zachariae R, 2001, AM HEART J, V142, P63, DOI 10.1067/mhj.2001.115794
   ZEIHER AM, 1995, CIRCULATION, V92, P1094, DOI 10.1161/01.CIR.92.5.1094
   ZEIHER AM, 1995, CIRCULATION, V91, P2345, DOI 10.1161/01.CIR.91.9.2345
NR 111
TC 37
Z9 40
U1 0
U2 15
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1358-863X
EI 1477-0377
J9 VASC MED
JI Vasc. Med.
PD APR
PY 2016
VL 21
IS 2
BP 146
EP 155
DI 10.1177/1358863X15618268
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DH6LB
UT WOS:000372901000009
PM 26675331
OA Bronze
DA 2025-06-11
ER

PT J
AU Yadav, D
   Mishra, M
   Joseph, AZ
   Subramani, SK
   Mahajan, S
   Singh, N
   Bisen, PS
   Prasad, GBKS
AF Yadav, Dhananjay
   Mishra, Meerambika
   Joseph, Anish Zacharia
   Subramani, Senthil Kumar
   Mahajan, Sunil
   Singh, Nita
   Bisen, Prakash Singh
   Prasad, G. B. K. S.
TI Status of antioxidant and lipid peroxidation in type 2 diabetic human
   subjects diagnosed with and without metabolic syndrome by using
   NCEP-ATPIII, IDF and WHO criteria
SO OBESITY RESEARCH & CLINICAL PRACTICE
LA English
DT Article
DE Metabolic syndrome; Catalase; Superoxide dismutase; Glutathione; Lipid
   peroxidation
ID OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; MELLITUS; COMPLICATIONS;
   PREDICTORS; ENZYME; ASSAY
AB Background: Antioxidants play a very crucial role in terms of disease incidence and its complications. Type 2 diabetes and metabolic syndrome (MetS) are now more prevalent than any other disorder. In this regard this study focuses on type 2 diabetic subjects with MetS having highest incidence of cardiovascular disease. Hence the aim of the study was to reveal the level of antioxidants and lipid peroxidation in MetS and non-MetS groups of type 2 diabetic subjects characterized by three different criteria.
   Methods: Present study was based on 70 type 2 diabetic subjects and 20 healthy controls. The metabolic syndrome criteria were defined by National Cholesterol Education Program (NCEP)-Adult Treatment Panel III (ATPIII), International Diabetes Federation (IDF), and World Health Organization (WHO). The selected subjects were of similar age group. The participants were selected from a diabetic camp being run in the University Campus. The antioxidant enzymes estimated were reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) while Thiobarbituric acid reactive substances (TBARS) measured as a marker of lipid peroxidation.
   Results: The level of GSH, CAT, SOD decreases in non-MetS and MetS subjects as compared to normal. When comparison was made for GSH & SOD in the mentioned groups resulted a significant differences in non-MetS and MetS compared with normal subjects. TBARS levels was increased in non-MetS and MetS group of subjects. The results indicate reduction in antioxidant enzymes and elevation of lipid peroxidation in type 2 diabetic subjects with or without MetS defined by using any of the International criteria.
   Conclusions: The study revealed that absolute reduction of antioxidant and involvement of lipid peroxidation in MetS group may lead to progressive intensification of cardiovascular disease in type 2 diabetic subjects irrespective of using any criteria. (C) 2014 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
C1 [Yadav, Dhananjay] Yonsei Univ, Wonju Coll Med, Dept Internal Med, Wonju, South Korea.
   [Mishra, Meerambika] Sambalpur Univ, Sch Life Sci, Burla, Odisha, India.
   [Yadav, Dhananjay; Joseph, Anish Zacharia; Subramani, Senthil Kumar; Mahajan, Sunil; Singh, Nita; Bisen, Prakash Singh; Prasad, G. B. K. S.] Jiwaji Univ, SOS Biochem, Gwalior, Madhya Pradesh, India.
C3 Yonsei University; Sambalpur University; Jiwaji University Gwalior
RP Yadav, D (corresponding author), Yonsei Univ, Wonju Coll Med, Dept Internal Med, Wonju, South Korea.
EM dhanyadav16481@gmail.com
RI Mishra, Meerambika/AAH-6380-2020; KUMAR, SUNIL/ABG-7529-2022; Bisen,
   Prakash/H-3392-2019; Yadav, Dhananjay/AAZ-9435-2021
OI subramani, senthilkumar/0000-0001-5603-3002; Mishra,
   Meerambika/0000-0001-7124-7367; JOSEPH, ANISH
   ZACHARIA/0000-0003-0258-3820
CR [Anonymous], 2002, CIRCULATION
   ARMSTRONG D, 1994, ADV EXP MED BIOL, V366, P43
   BAYNES JW, 1991, DIABETES, V40, P405, DOI 10.2337/diabetes.40.4.405
   Church TS, 2009, DIABETES CARE, V32, P1289, DOI 10.2337/dc08-1871
   ELLMAN GL, 1959, ARCH BIOCHEM BIOPHYS, V82, P70, DOI 10.1016/0003-9861(59)90090-6
   Ford Earl S, 2003, Endocr Pract, V9 Suppl 2, P23
   FOSSATI P, 1982, CLIN CHEM, V28, P2077
   GIUGLIANO D, 1995, METABOLISM, V44, P363, DOI 10.1016/0026-0495(95)90167-1
   Grattagliano I, 2008, J NUTR BIOCHEM, V19, P491, DOI 10.1016/j.jnutbio.2007.06.011
   Linke A, 2005, CIRCULATION, V111, P1763, DOI 10.1161/01.CIR.0000165503.08661.E5
   Lopes-Virella M., 1997, CLIN CHEM, V23, P882
   LYONS TJ, 1991, DIABETIC MED, V8, P411, DOI 10.1111/j.1464-5491.1991.tb01624.x
   Maritim AC, 2003, J BIOCHEM MOL TOXIC, V17, P24, DOI 10.1002/jbt.10058
   Matsunami T, 2010, PHYSIOL RES, V59, P97, DOI 10.33549/physiolres.931711
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   Reitman A, 2002, ISRAEL MED ASSOC J, V4, P590
   SINHA AK, 1972, ANAL BIOCHEM, V47, P389, DOI 10.1016/0003-2697(72)90132-7
   Sone H, 2009, J ATHEROSCLER THROMB, V16, P380, DOI 10.5551/jat.No117
   STOCKBRIDGE H, 1989, J LAB CLIN MED, V114, P142
   Trevisan M, 2001, AM J EPIDEMIOL, V154, P348, DOI 10.1093/aje/154.4.348
   Trinder P., 1969, Journal of Clinical Pathology, V22, P158, DOI 10.1136/jcp.22.2.158
   Turko IV, 2001, AM J PHYSIOL-HEART C, V281, pH2289, DOI 10.1152/ajpheart.2001.281.6.H2289
   Vega-López S, 2004, J INVEST MED, V52, P24, DOI 10.1136/jim-52-01-23
   Wilson PWF, 2005, CIRCULATION, V112, P3066, DOI 10.1161/CIRCULATIONAHA.105.539528
   WINTERBOURN CC, 1975, J LAB CLIN MED, V85, P337
   Zimmet PZ, 1997, J DIABETES COMPLICAT, V11, P60, DOI 10.1016/S1056-8727(96)00090-6
NR 26
TC 11
Z9 12
U1 0
U2 9
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-403X
EI 1878-0318
J9 OBES RES CLIN PRACT
JI Obes. Res. Clin. Pract.
PD MAR-APR
PY 2015
VL 9
IS 2
BP 158
EP 167
DI 10.1016/j.orcp.2014.03.004
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA CG1XJ
UT WOS:000353068500007
PM 25890429
DA 2025-06-11
ER

PT J
AU Taormina, JM
   Iwamoto, SJ
AF Taormina, John Michael
   Iwamoto, Sean J.
TI Filling a gap in care: addressing obesity in transgender and gender
   diverse patients
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID DISPARITIES
AB Transgender and gender diverse (TGD) adults are more likely to have obesity compared to cisgender peers. Based on surveys, the TGD population experiences disparities in healthy lifestyle behaviors (e.g., physical activity, screen time) compared to reference groups. They also face significant socioeconomic and healthcare barriers to accessing affirming care and gender minority stress, potentially contributing to increased weight. Gender-affirming hormone therapy is associated with changes in body composition and increased weight, which may impact cardiometabolic risk trajectory. Obesity can also be a barrier to gender-affirming surgeries, and affirming weight management services tailored to TGD patients are an important gap in healthcare to address. This Perspective briefly reviews current literature on the unique barriers experienced by TGD people and their identified needs regarding weight management interventions. It also suggests areas for future research to best fill this gap in healthcare and research while supporting the provision of lifesaving gender-affirming care.
C1 [Taormina, John Michael; Iwamoto, Sean J.] Univ Colorado, Sch Med, Anschutz Hlth & Wellness Ctr, Anschutz Med Campus, Aurora, CO 80045 USA.
   [Taormina, John Michael; Iwamoto, Sean J.] Univ Colorado, Sch Med, Dept Med, Div Endocrinol Metab & Diabet, Anschutz Med Campus, Aurora, CO 80045 USA.
   [Taormina, John Michael; Iwamoto, Sean J.] UCHlth Integrated Transgender Program, Aurora, CO 80045 USA.
   [Iwamoto, Sean J.] Eastern Colorado Hlth Care Syst, Rocky Mt Reg Vet Adm Med Ctr, Endocrinol Serv, Med Serv, Aurora, CO USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; University of Colorado System; University of Colorado Anschutz
   Medical Campus
RP Taormina, JM (corresponding author), Univ Colorado, Sch Med, Anschutz Hlth & Wellness Ctr, Anschutz Med Campus, Aurora, CO 80045 USA.; Taormina, JM (corresponding author), Univ Colorado, Sch Med, Dept Med, Div Endocrinol Metab & Diabet, Anschutz Med Campus, Aurora, CO 80045 USA.; Taormina, JM (corresponding author), UCHlth Integrated Transgender Program, Aurora, CO 80045 USA.
EM john.taormina@cuanschutz.edu
RI Taormina, John/LFT-4962-2024
OI Taormina, John/0009-0008-7060-3735; Iwamoto, Sean/0000-0002-7316-8256
FU Eunice Kennedy Shriver National Institute of Child Health amp; Human
   Development grant (The Colorado Building Interdisciplinary Research
   Careers in Women's Health [BIRCWH] Program) [5K12HD057022]
FX JMT has no financial disclosures. SJI receives funding & nbsp;&
   nbsp;through a Eunice Kennedy Shriver National Institute of Child Health
   & Human Development grant (The Colorado Building Interdisciplinary
   Research Careers in Women's Health [BIRCWH] Program; supported by
   5K12HD057022, PIs: Regensteiner JG and Santoro NF).
CR Bigarella LG, 2022, AESTHET SURG J, V42, P795, DOI 10.1093/asj/sjab397
   Brown GR, 2016, LGBT HEALTH, V3, P122, DOI 10.1089/lgbt.2015.0058
   Brownstone LM, 2021, TRANSGENDER HEALTH, V6, P121, DOI 10.1089/trgh.2020.0068
   Christian R, 2018, J GEN INTERN MED, V33, P1654, DOI 10.1007/s11606-018-4450-6
   Diamond LM, 2022, NEUROSCI BIOBEHAV R, V138, DOI 10.1016/j.neubiorev.2022.104720
   Dragon CN, 2017, LGBT HEALTH, V4, P404, DOI 10.1089/lgbt.2016.0208
   Fisher AD, 2016, J CLIN ENDOCR METAB, V101, P4260, DOI 10.1210/jc.2016-1276
   Inst Med, 2011, HEALTH OF LESBIAN, GAY, BISEXUAL, AND TRANSGENDER PEOPLE: BUILDING A FOUNDATION FOR BETTER UNDERSTANDING, P1
   Kirby SR, 2020, TRANSGENDER HEALTH, V5, P33, DOI 10.1089/trgh.2019.0071
   Klaver M, 2017, ANDROLOGIA, V49, DOI 10.1111/and.12660
   Kyinn M, 2021, INT J OBESITY, V45, P2562, DOI 10.1038/s41366-021-00935-x
   Martinson TG, 2020, ENDOCR PRACT, V26, P6, DOI 10.4158/EP-2019-0345
   Nagata JM, 2020, CURR OPIN PSYCHIATR, V33, P562, DOI 10.1097/YCO.0000000000000645
   Newcomb ME, 2020, ARCH SEX BEHAV, V49, P645, DOI 10.1007/s10508-019-01533-9
   Silva ED, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.621075
   van der Sluis WB, 2022, INT J TRANSGEND HEAL, V23, P355, DOI 10.1080/26895269.2021.1890302
   VanKim NA, 2014, HEALTH BEHAV POLICY, V1, P161, DOI 10.14485/HBPR.1.2.8
NR 17
TC 6
Z9 7
U1 0
U2 1
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD SEP
PY 2023
VL 47
IS 9
BP 761
EP 763
DI 10.1038/s41366-023-01334-0
EA JUL 2023
PG 3
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA P2AA8
UT WOS:001023393300001
PM 37414875
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Yang, SW
   Yang, HF
   Chen, YY
   Chen, WL
AF Yang, Shih-Wei
   Yang, Hui-Fang
   Chen, Yuan-Yuei
   Chen, Wei-Liang
TI Unraveling the link between metabolic syndrome and abdominal aortic
   calcification
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Metabolic syndrome; Abdominal aortic; calcification; Atherosclerosis
ID CORONARY-HEART-DISEASE; OXIDATIVE STRESS; UNITED-STATES;
   ATHEROSCLEROSIS; MORBIDITY; MORTALITY; OBESITY; SCORE; RISK; SEX
AB Background & aims: Over the last few decades, the prevalence of metabolic syndrome (MetS) has gradually increased. As we know, many prior studies have connected MetS with diabetes, coronary heart disease, and cardiovascular disease. Abdominal aortic calcification (AAC) is a good marker of morbidity and mortality of vascular disease, as its degree may be associated with the severity of coronary artery calcification and disease. The aim of this article is to investigate the connection between MetS and AAC.
   Methods and results: This retrospective observational study included 2731 participants aged 58 years from the National Health and Nutrition Examination Survey (NHANES) (2013-2014). We used Dual-Energy X-ray Absorptiometry to define the degree of AAC. We defined MetS according to the National Cholesterol Education Program Adult Treatment Panel III definition.
   A total of 2731 participants with complete data were included for data analysis. In the fully adjusted model, an increase in the severity of AAC with the number of MetS components was still significant with beta values of AAC Total 24 Score 0.498 (95% confidence interval (CI): 0.018,0.978), 1.016 (95% CI: 0.514,1.519) and 1.426 (95% CI: 0.916,1.937) respectively in 2, 3 and >= 4 components. Additionally, associations were observed between MetS components, including blood pressure, HDL and glucose with beta values of AAC Total 24 Score 0.332(95% CI: 0.069, 0.595), 0.652(95% CI: 0.380, 0.925) and 0.534 (95% CI: 0.285, 0.783) after fully adjusted, respectively.
   Conclusion: The results indicated that, in the US adult population, a greater number of components of MetS were significantly associated with AAC. Among the components of metabolic syndrome, the blood pressure, HDL and blood sugar were observed apparent association with AAC. (C) 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
C1 [Yang, Shih-Wei] Triserv Gen Hosp, Dept Orthoped, Taipei, Taiwan.
   [Yang, Shih-Wei; Yang, Hui-Fang; Chen, Yuan-Yuei; Chen, Wei-Liang] Natl Def Med Ctr, Sch Med, Taipei, Taiwan.
   [Yang, Shih-Wei; Yang, Hui-Fang; Chen, Yuan-Yuei; Chen, Wei-Liang] Triserv Gen Hosp, Dept Family & Community Med, Div Family Med, Taipei, Taiwan.
   [Yang, Hui-Fang; Chen, Wei-Liang] Triserv Gen Hosp, Dept Family & Community Med, Div Geriatr Med, Taipei, Taiwan.
   [Chen, Yuan-Yuei] Triserv Gen Hosp, Dept Pathol, Songshan Branch, Taipei, Taiwan.
C3 Tri-Service General Hospital; National Defense Medical Center;
   Tri-Service General Hospital; Tri-Service General Hospital; Tri-Service
   General Hospital
RP Chen, WL (corresponding author), Triserv Gen Hosp, Natl Def Med Ctr, Dept Family Med, Div Geriatr Med, 325 Sect 2,Chang Gong Rd, Taipei 114, Taiwan.
EM weiliang0508@gmail.com
OI Yang, Hui-Fang/0000-0001-6400-0462
CR Azumi H, 2002, ARTERIOSCL THROM VAS, V22, P1838, DOI 10.1161/01.ATV.0000037101.40667.62
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   COCKERILL GW, 1995, ARTERIOSCL THROM VAS, V15, P1987, DOI 10.1161/01.ATV.15.11.1987
   De Mattia G, 2008, DIABETES RES CLIN PR, V79, P337, DOI 10.1016/j.diabres.2007.09.005
   Eun YM, 2016, ANN SAUDI MED, V36, P334, DOI 10.5144/0256-4947.2016.334
   Fortuño A, 2006, DIABETES, V55, P209, DOI 10.2337/diabetes.55.1.209
   Gurka MJ, 2017, DIABETOLOGIA, V60, P1261, DOI 10.1007/s00125-017-4267-6
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Hutcheson Rebecca, 2012, Exp Diabetes Res, V2012, P271028, DOI 10.1155/2012/271028
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jensky NE, 2010, HYPERTENSION, V55, P990, DOI 10.1161/HYPERTENSIONAHA.109.147520
   Katz R, 2016, DIABETIC MED, V33, P912, DOI 10.1111/dme.12958
   Kim HJ, 2018, BIOMED RES INT, V2018, DOI 10.1155/2018/4619867
   Kontush A, 2014, CARDIOVASC RES, V103, P341, DOI 10.1093/cvr/cvu147
   Leopold JA, 2015, TRENDS CARDIOVAS MED, V25, P267, DOI 10.1016/j.tcm.2014.10.021
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Malik S, 2017, JAMA CARDIOL, V2, P1332, DOI 10.1001/jamacardio.2017.4191
   Moebus S, 2009, DIABETOLOGIA, V52, P81, DOI 10.1007/s00125-008-1173-y
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   Nofer JR, 1998, ARTERIOSCL THROM VAS, V18, P861, DOI 10.1161/01.ATV.18.6.861
   Olijhoek JK, 2004, EUR HEART J, V25, P342, DOI 10.1016/j.ehj.2003.12.007
   Parhami F, 2002, CIRC RES, V91, P570, DOI 10.1161/01.RES.0000036607.05037.DA
   Redón J, 2003, HYPERTENSION, V41, P1096, DOI 10.1161/01.HYP.0000068370.21009.38
   Roberts CK, 2013, COMPR PHYSIOL, V3, P1, DOI 10.1002/cphy.c110062
   Said S, 2016, CURR VASC PHARMACOL, V14, P415, DOI 10.2174/1570161114666160722121615
   Tesauro M, 2011, ACTA PHYSIOL, V203, P279, DOI 10.1111/j.1748-1716.2011.02290.x
   Wilson PWF, 2001, CIRCULATION, V103, P1529, DOI 10.1161/01.cir.103.11.1529
   Yildiz S, 2014, CLINICS, V69, P841, DOI 10.6061/clinics/2014(12)09
   Yuan MX, 2016, OBESITY, V24, P1810, DOI 10.1002/oby.21540
NR 29
TC 26
Z9 27
U1 0
U2 9
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD FEB 8
PY 2021
VL 31
IS 2
BP 464
EP 471
DI 10.1016/j.numecd.2020.10.003
EA FEB 2021
PG 8
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA QI3IN
UT WOS:000618872600013
PM 33223398
DA 2025-06-11
ER

PT J
AU Dupas, J
   Feray, A
   Guernec, A
   Pengam, M
   Inizan, M
   Guerrero, F
   Mansourati, J
   Goanvec, C
AF Dupas, Julie
   Feray, Annie
   Guernec, Anthony
   Pengam, Morgane
   Inizan, Manon
   Guerrero, Francois
   Mansourati, Jacques
   Goanvec, Christelle
TI Effect of personalized moderate exercise training on Wistar rats fed
   with a fructose enriched water
SO NUTRITION & METABOLISM
LA English
DT Article
DE Metabolic syndrome; Fructose enriched water rat model; Aerobic training
ID ADIPONECTIN-LEPTIN RATIO; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   MITOCHONDRIAL-FUNCTION; GLUCOSE-TOLERANCE; OXIDATIVE STRESS; RICH DIET;
   HEART; EXPRESSION; MUSCLE
AB Background: Metabolic Syndrom has become a public health problem. It mainly results from the increased consumption of fat and sugar. In this context, the benefits of personalized moderate exercise training were investigated on a metabolic syndrome male wistar rat model food with fructose drinking water (20-25% w/v). Different markers including body weight, metabolic measurements, blood biochemistry related to metabolic syndrome complications have been evaluated.
   Methods: Male Wistar rats were randomly allocated to 4 groups: control (sedentary (C, n = 8) and exercise trained (Ex, n = 8)), fructose fed (sedentary (FF, n = 8) and exercise trained fructose fed rats (ExFF, n = 10)). ExFF and Ex rats were trained at moderate intensity during the last 6 weeks of the 12 weeks-long protocol of fructose enriched water. Metabolic control was determined by measuring body weight, fasting blood glucose, HOMA 2-IR, HIRI, MISI, leptin, adiponectin, triglyceridemia and hepatic dysfunction.
   Results: After 12 weeks of fructose enriched diet, rats displayed on elevated fasting glycaemia and insulin resistance. A reduced food intake, as well as increased body weight, total calorie intake and heart weight were also observed in FF group. Concerning biochemical markers, theoretical creatinine clearance, TG levels and ASAT/ALAT ratio were also affected, without hepatic steatosis. Six weeks of 300 min/week of moderate exercise training have significantly improved overweight, fasting glycaemia, HOMA 2-IR, MISI without modify HIRI. Exercise also decreased the plasma levels of leptin, adiponectin and the ratio leptin/adiponectin. Regarding liver function and dyslipidemia, the results were less clear as the effects of exercise and fructose-enriched water interact together, and, sometimes counteract each other.
   Conclusion: Our results indicated that positive health effects were achieved through a personalized moderate training of 300 min per week (1 h/day and 5 days/week) for 6 weeks. Therefore, regular practice of aerobic physical exercise is an essential triggering factor to attenuate MetS disorders induced by excessive fructose consumption.
C1 [Dupas, Julie; Feray, Annie; Guernec, Anthony; Pengam, Morgane; Inizan, Manon; Guerrero, Francois; Mansourati, Jacques; Goanvec, Christelle] Univ Bretagne Occidentale, EA Optimisat Regulat Physiol 4324, 6 Ave Le Gorgeu, F-29238 Brest 3, France.
   [Inizan, Manon; Goanvec, Christelle] Univ Bretagne Occidentale, UFR Sci & Tech, 6 Ave Le Gorgeu, F-29237 Brest 3, France.
   [Feray, Annie; Guernec, Anthony; Guerrero, Francois] Univ Bretagne Occidentale, UFR Sci Sport & Educ, 20 Ave Le Gorgeu, F-29238 Brest 3, France.
   [Mansourati, Jacques] CHU Brest, Dept Cardiol, Blvd Tanguy Prigent, F-29200 Brest, France.
   [Feray, Annie; Guernec, Anthony; Pengam, Morgane; Inizan, Manon; Guerrero, Francois; Mansourati, Jacques; Goanvec, Christelle] IBSAM, UFR Med, Ave Camille Desmoulin, F-29200 Brest, France.
C3 Universite de Bretagne Occidentale; Universite de Bretagne Occidentale;
   Universite de Bretagne Occidentale; CHU Brest; Universite de Bretagne
   Occidentale
RP Goanvec, C (corresponding author), Univ Bretagne Occidentale, EA Optimisat Regulat Physiol 4324, 6 Ave Le Gorgeu, F-29238 Brest 3, France.; Goanvec, C (corresponding author), Univ Bretagne Occidentale, UFR Sci & Tech, 6 Ave Le Gorgeu, F-29237 Brest 3, France.
EM christelle.goanvec@univ-brest.fr
RI Mansourati, Jacques/HLQ-5147-2023
OI goanvec, christelle/0000-0002-1764-6778; Guerrero,
   Francois/0000-0002-0283-3503
FU Federation Francaise de Cardiologie
FX This study was partially funded by a research grant from the Federation
   Francaise de Cardiologie. Authors wish to acknowledge Nathalie
   GUEGUENIAT<SUP>1</SUP>, Jean L'HEGARET<SUP>1</SUP>, Stephane
   VIELLEDENT<SUP>3</SUP> and Charlene ALAIN<SUP>1</SUP> for the help they
   gave us in this project.
CR Abdul-Ghani MA, 2007, DIABETES CARE, V30, P89, DOI 10.2337/dc06-1519
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Aydin S, 2014, NUTRITION, V30, P1, DOI 10.1016/j.nut.2013.05.013
   Basciano Heather, 2005, Nutr Metab (Lond), V2, P5, DOI 10.1186/1743-7075-2-5
   Bettaieb A, 2014, FREE RADICAL BIO MED, V72, P247, DOI 10.1016/j.freeradbiomed.2014.04.011
   Bidwell AJ, 2017, NUTRIENTS, V9, DOI 10.3390/nu9060549
   Bird Stephen R, 2016, BMJ Open Sport Exerc Med, V2, pe000143, DOI 10.1136/bmjsem-2016-000143
   Botezelli JD, 2016, SCI REP-UK, V6, DOI 10.1038/srep31106
   Botezelli JD, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-116
   Bundalo M, 2017, EUR J PHARMACOL, V811, P141, DOI 10.1016/j.ejphar.2017.06.003
   Caillaud K, 2016, DIABETES METAB, V42, P96, DOI 10.1016/j.diabet.2015.08.003
   Cambri LT, 2015, J DEV ORIG HLTH DIS, V6, P335, DOI 10.1017/S2040174415001026
   Chen VCH, 2018, PSYCHONEUROENDOCRINO, V92, P34, DOI 10.1016/j.psyneuen.2018.03.021
   COCKCROFT DW, 1976, NEPHRON, V16, P31, DOI 10.1159/000180580
   Colberg SR, 2016, DIABETES CARE, V39, P2065, DOI 10.2337/dc16-1728
   Frantz EDC, 2017, EXP PHYSIOL, V102, P1208, DOI 10.1113/EP085924
   Doggrell SA, 1998, CARDIOVASC RES, V39, P89, DOI 10.1016/S0008-6363(98)00076-5
   Dufour DR, 2000, CLIN CHEM, V46, P2027
   Dupas J, 2017, BIOMED RES INT, V2017, DOI 10.1155/2017/2494067
   Dupas J, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0146821
   Egli L, 2016, AM J CLIN NUTR, V103, P348, DOI 10.3945/ajcn.115.116988
   Egli L, 2013, DIABETES, V62, P2259, DOI 10.2337/db12-1651
   Elliott SS, 2002, AM J CLIN NUTR, V76, P911, DOI 10.1093/ajcn/76.5.911
   Falahi E, 2015, DIABETES METAB SYND, V9, P366, DOI 10.1016/j.dsx.2013.06.014
   Farah D, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0167291
   Farhat F, 2017, REDOX REP, V22, P508, DOI 10.1080/13510002.2017.1296637
   Farhat F, 2015, REDOX REP, V20, P60, DOI 10.1179/1351000214Y.0000000105
   Frühbeck G, 2018, ADIPOCYTE, V7, P57, DOI 10.1080/21623945.2017.1402151
   Gayoso-Diz P, 2013, BMC ENDOCR DISORD, V13, DOI 10.1186/1472-6823-13-47
   Görgens SW, 2015, PROG MOL BIOL TRANSL, V135, P313, DOI 10.1016/bs.pmbts.2015.07.002
   González-Torres L, 2015, J PHYSIOL BIOCHEM, V71, P773, DOI 10.1007/s13105-015-0441-9
   Goto C, 2003, CIRCULATION, V108, P530, DOI 10.1161/01.CIR.0000080893.55729.28
   Inoue M, 2005, METABOLISM, V54, P281, DOI 10.1016/j.metabol.2004.09.006
   Jang C, 2018, CELL METAB, V27, P351, DOI 10.1016/j.cmet.2017.12.016
   Jung Chan-Hee, 2010, Korean Diabetes J, V34, P237, DOI 10.4093/kdj.2010.34.4.237
   Koricanac G, 2013, ARCH BIOL SCI, V65, P455, DOI 10.2298/ABS1302455K
   Lamarche B, 1999, DIABETES METAB, V25, P199
   Li XD, 2011, PROTEIN CELL, V2, P189, DOI 10.1007/s13238-011-1016-3
   López-Jaramillo P, 2014, HORM MOL BIOL CLIN I, V18, P37, DOI 10.1515/hmbci-2013-0053
   Lozano I, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0074-1
   Machado MV, 2017, EXP PHYSIOL, V102, P1716, DOI [10.1113/EP086416, 1]
   Malik VS, 2010, DIABETES CARE, V33, P2477, DOI 10.2337/dc10-1079
   Mamikutty N, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/895961
   Mamikutty N, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/263897
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Metkus TS, 2010, CIRCULATION, V121, P2601, DOI 10.1161/CIRCULATIONAHA.109.903377
   Ndlovu T, 2007, AFR J BIOTECHNOL, V6, P2727
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Pereira RM, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040405
   PICKART L, 1983, ATHEROSCLEROSIS, V46, P21, DOI 10.1016/0021-9150(83)90160-0
   POORTMANS JR, 1984, SPORTS MED, V1, P125, DOI 10.2165/00007256-198401020-00003
   Ramos D, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0131766
   Ramos-Romero S, 2018, AM J PHYSIOL-ENDOC M, V314, pE552, DOI 10.1152/ajpendo.00323.2017
   Rippe JM, 2016, EUR J NUTR, V55, pS11, DOI 10.1007/s00394-016-1227-8
   Ritz E, 1999, AM J KIDNEY DIS, V34, P795, DOI 10.1016/S0272-6386(99)70035-1
   Sangüesa G, 2019, EUR J NUTR, V58, P1283, DOI 10.1007/s00394-018-1654-9
   Simpson KA, 2008, OBESITY, V16, P241, DOI 10.1038/oby.2007.53
   Siu PM, 2003, J APPL PHYSIOL, V94, P555, DOI 10.1152/japplphysiol.00821.2002
   Spier SA, 1999, J APPL PHYSIOL, V87, P1752, DOI 10.1152/jappl.1999.87.5.1752
   Tappy L, 2012, BMC BIOL, V10, DOI 10.1186/1741-7007-10-42
   Tappy L, 2010, PHYSIOL REV, V90, P23, DOI 10.1152/physrev.00019.2009
   ter Horst KW, 2017, NUTRIENTS, V9, DOI 10.3390/nu9090981
   Tran LT, 2009, MOL CELL BIOCHEM, V332, P145, DOI 10.1007/s11010-009-0184-4
   Vega GL, 2013, J OBES, V2013, DOI 10.1155/2013/409679
   Vilà L, 2011, J NUTR BIOCHEM, V22, P741, DOI 10.1016/j.jnutbio.2010.06.005
   WALLERSTEDT S, 1974, ACTA MED SCAND, V195, P227
   Whiting DR, 2011, DIABETES RES CLIN PR, V94, P311, DOI 10.1016/j.diabres.2011.10.029
   Wu HJ, 2004, WORLD J GASTROENTERO, V10, P2711, DOI 10.3748/wjg.v10.i18.2711
   Yoshida Akihiro, 2004, J Atheroscler Thromb, V11, P215
   Yuan G, 2007, ENDOCRINOLOGY, V148, P2016, DOI 10.1210/en.2006-0602
NR 70
TC 8
Z9 8
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD OCT 3
PY 2018
VL 15
AR 69
DI 10.1186/s12986-018-0307-6
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GV9VW
UT WOS:000446510800001
PM 30305835
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Coutinho, AE
   Campbell, JE
   Fediuc, S
   Riddell, MC
AF Coutinho, AE
   Campbell, JE
   Fediuc, S
   Riddell, MC
TI Effect of voluntary exercise on peripheral tissue glucocorticoid
   receptor content and the expression and activity of 11β-HSD1 in the
   Syrian hamster
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE voluntary wheel running; corticosterone; metabolism; visceral fat; 11
   beta-hydroxysteroid dehydrogenase type 1
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; METABOLIC SYNDROME;
   CUSHINGS-DISEASE; SKELETAL-MUSCLE; OBESITY; STRESS; FAT; CORTICOSTERONE;
   HEPATOCYTES; CONTRIBUTE
AB Recent findings indicate that elevated levels of glucocorticoids (GC), governed by the expression of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) and GC receptors (GR), in visceral adipose tissue and skeletal muscle lead to increased insulin resistance and the metabolic syndrome. Paradoxically, evidence indicates that aerobic exercise attenuates the development of the metabolic syndrome even though it stimulates acute increases in circulating GC levels. To investigate the hypothesis that training alters peripheral GC action to maintain insulin sensitivity, young male hamsters were randomly divided into sedentary (S) and trained (T) groups (n = 8 in each). The T group had 24-h access to running wheels over 4 wk of study. In muscle, T hamsters had lower 11 beta-HSD1 protein expression (19.2 +/- 1.40 vs. 22.2 +/- 0.96 optical density, P < 0.05), similar 11 beta-HSD1 enzyme activity (0.9 +/- 0.27% vs. 1.1 +/- 0.26), and lower GR protein expression (9.7 +/- 1.86 vs. 15.1 +/- 1.78 optical density, P < 0.01) than S hamsters. In liver, 11 beta-HSD1 protein expression tended to be lower in T compared with S (19.2 +/- 0.56 vs. 21.4 +/- 1.05, P = 0.07), whereas both enzyme activity and GR protein expression were similar. In contrast, visceral adipose tissue contained similar to 2.7-fold higher 11 beta-HSD1 enzyme activity in T compared with S (12.9 +/- 3.3 vs. 4.8 +/- 1.5% conversion, P < 0.05) but was considerably smaller in mass (0.24 +/- 0.02 vs. 0.71 +/- 0.06 g). Thus the intracellular adaptation of GC regulators to exercise is tissue specific, resulting in decreases in GC action in skeletal muscle and increases in GC action in visceral fat. These adaptations may have important implications in explaining the protective effects of aerobic exercise on insulin resistance and other symptoms of the metabolic syndrome.
C1 York Univ, Dept Kinesiol & Hlth Sci, Toronto, ON M3J 2R7, Canada.
C3 York University - Canada
RP 347 Bethune Coll,4700 Keele St, Toronto, ON M3J 1P3, Canada.
EM mriddell@yorku.ca
OI Campbell, Jonathan/0000-0001-8223-1600
CR Andrews RC, 1999, CLIN SCI, V96, P513, DOI 10.1042/cs0960513
   Bähr V, 2002, EXP CLIN ENDOCR DIAB, V110, P313, DOI 10.1055/s-2002-34996
   BORER KT, 1992, PHYSIOL BEHAV, V51, P713, DOI 10.1016/0031-9384(92)90106-C
   Bujalska IJ, 1997, LANCET, V349, P1210, DOI 10.1016/S0140-6736(96)11222-8
   Chan O, 2003, Minerva Endocrinol, V28, P87
   Chapman KE, 1997, BIOCHEM SOC T, V25, P583, DOI 10.1042/bst0250583
   Fediuc S, 2005, DIABETES, V54, pA263
   Gordon JW, 2001, J APPL PHYSIOL, V90, P389, DOI 10.1152/jappl.2001.90.1.389
   JAMIESON PM, 1995, ENDOCRINOLOGY, V136, P4754, DOI 10.1210/en.136.11.4754
   Kump DS, 2005, J PHYSIOL-LONDON, V565, P911, DOI 10.1113/jphysiol.2005.084525
   Liu YJ, 2005, DIABETES, V54, P32, DOI 10.2337/diabetes.54.1.32
   Masuzaki H, 2001, SCIENCE, V294, P2166, DOI 10.1126/science.1066285
   Mattson JP, 2002, J HISTOCHEM CYTOCHEM, V50, P1685, DOI 10.1177/002215540205001214
   Morton NM, 2004, ENDOCRINOLOGY, V145, P2707, DOI 10.1210/en.2003-1674
   Park E, 2005, AM J PHYSIOL-REG I, V289, pR1360, DOI 10.1152/ajpregu.00103.2005
   Paterson JM, 2004, P NATL ACAD SCI USA, V101, P7088, DOI 10.1073/pnas.0305524101
   Perelló M, 2004, NEUROENDOCRINOL LETT, V25, P119
   Riddell MC., 2003, Exercise Physiology- People and Ideas, P361, DOI [10.1016/B978-019512527-6.50010-6, DOI 10.1016/B978-019512527-6.50010-6]
   Saengsirisuwan V, 2004, AM J PHYSIOL-ENDOC M, V287, pE529, DOI 10.1152/ajpendo.00013.2004
   Sapolsky RM, 2000, ENDOCR REV, V21, P55, DOI 10.1210/er.21.1.55
   Seckl JR, 2004, CURR OPIN PHARMACOL, V4, P597, DOI 10.1016/j.coph.2004.09.001
   Shipp K, 1998, CONTEMP TOP LAB ANIM, V37, P73
   STARZEC JJ, 1983, PSYCHOSOM MED, V45, P219, DOI 10.1097/00006842-198306000-00004
   Tomlinson JW, 2004, J CLIN ENDOCR METAB, V89, P2711, DOI 10.1210/jc.2003-031376
   Tomlinson JW, 2004, J ENDOCRINOL INVEST, V27, P171, DOI 10.1007/BF03346264
   Whorwood CB, 2002, DIABETES, V51, P1066, DOI 10.2337/diabetes.51.4.1066
NR 26
TC 37
Z9 44
U1 0
U2 1
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
EI 1522-1601
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD MAY
PY 2006
VL 100
IS 5
BP 1483
EP 1488
DI 10.1152/japplphysiol.01236.2005
PG 6
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA 040DE
UT WOS:000237358400010
PM 16357069
DA 2025-06-11
ER

PT J
AU da Costa, RM
   da Silva, JF
   Alves, JV
   Dias, TB
   Rassi, DM
   Garcia, LV
   Lobato, ND
   Tostes, RC
AF da Costa, Rafael M.
   da Silva, Josiane F.
   Alves, Juliano V.
   Dias, Thiago B.
   Rassi, Diane M.
   Garcia, Luis V.
   Lobato, Nubia de Souza
   Tostes, Rita C.
TI Increased O-GlcNAcylation of Endothelial Nitric Oxide Synthase
   Compromises the Anti-contractile Properties of Perivascular Adipose
   Tissue in Metabolic Syndrome
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE PVAT; O-GlcNAc; high-sugar diet; eNOS; vascular function
ID BETA-N-ACETYLGLUCOSAMINE; VASCULAR DYSFUNCTION; INSULIN-RESISTANCE;
   DIABETIC COMPLICATIONS; CARDIOVASCULAR-SYSTEM; LINKED GLYCOSYLATION;
   OXIDATIVE STRESS; OBESE MICE; ACTIVATION; PROTEINS
AB Under physiological conditions, the perivascular adipose tissue (PVAT) negatively modulates vascular contractility. This property is lost in experimental and human obesity and in the metabolic syndrome, indicating that changes in PVAT function may contribute to vascular dysfunction associated with increased body weight and hyperglycemia. The O-linked beta-N-acetylglucosamine (O-GlcNAc) modification of proteins (O-GlcNAcylation) is a unique posttranslational process that integrates glucose metabolism with intracellular protein activity. Increased flux of glucose through the hexosamine biosynthetic pathway and the consequent increase in tissue-specific O-GlcNAc modification of proteins have been linked to multiple facets of vascular dysfunction in diabetes and other pathological conditions. We hypothesized that chronic consumption of glucose, a condition that progresses tometabolic syndrome, leads to increased O-GlcNAcmodification of proteins in the PVAT, decreasing its anti-contractile effects. Therefore, the current study was devised to determine whether a high-sugar diet increases O-GlcNAcylation in the PVAT and how increased O-GlcNAc interferes with PVAT vasorelaxant function. To assess molecular mechanisms by which O-GlcNAc contributes to PVAT dysfunction, thoracic aortas surrounded by PVAT were isolated from Wistar rats fed either a control or high sugar diet, for 10 and 12 weeks. Rats chronically fed a high sugar diet exhibited metabolic syndrome features, increased O-GlcNAcylated-proteins in the PVAT and loss of PVAT anti-contractile effect. PVAT from high sugar diet-fed rats for 12 weeks exhibited decreased NO formation, reduced expression of endothelial nitric oxide synthase (eNOS) and increased O-GlcNAcylation of eNOS. High sugar diet also decreased OGA activity and increased superoxide anion generation in the PVAT. Visceral adipose tissue samples from hyperglycemic patients showed increased levels of O-GlcNAc-modified proteins, increased ROS generation and decreased OGA activity. These data indicate that O-GlcNAcylation contributes to metabolic syndrome-induced PVAT dysfunction and that O-GlcNAcylation of eNOS may be targeted in the development of novel therapies for vascular dysfunction in conditions associated with hyperglycemia.
C1 [da Costa, Rafael M.; da Silva, Josiane F.; Alves, Juliano V.; Dias, Thiago B.; Rassi, Diane M.; Tostes, Rita C.] Univ Sao Paulo, Dept Pharmacol, Ribeirao Preto Med Sch, Ribeirao Preto, Brazil.
   [Garcia, Luis V.] Univ Sao Paulo, Dept Biomech Med & Locomot Apparat Rehabil, Ribeirao Preto Med Sch, Ribeirao Preto, Brazil.
   [Lobato, Nubia de Souza] Univ Fed Goias, Inst Hlth Sci, Dept Physiol, Jatai, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade
   Federal de Goias
RP da Costa, RM (corresponding author), Univ Sao Paulo, Dept Pharmacol, Ribeirao Preto Med Sch, Ribeirao Preto, Brazil.
EM rafael.menezess@yahoo.com.br
RI Silva, Josiane/AAM-9261-2020; Costa, Rafael/K-4606-2017; Garcia,
   Luis/L-4295-2014; Alves, Juliano/AAE-3541-2020; Tostes, Rita/C-1025-2012
OI Alves, Juliano Vilela/0000-0002-6555-5547; Menezes da Costa,
   Rafael/0000-0002-5174-5710; Silva, Josiane/0000-0002-6623-7946
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP-CRID)
   [2013/08216-2]; Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior (CAPES); Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq), Brazil
FX This work was supported by grants from Fundacao de Amparo a Pesquisa do
   Estado de Sao Paulo (FAPESP-CRID 2013/08216-2 to RT), Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Conselho Nacional
   de Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil.
CR Alves-Lopes R, 2016, HYPERTENSION, V68, P1056, DOI 10.1161/HYPERTENSIONAHA.116.07518
   Arias EB, 2004, DIABETES, V53, P921, DOI 10.2337/diabetes.53.4.921
   Beleznai T, 2012, VASC PHARMACOL, V56, P115, DOI 10.1016/j.vph.2011.11.003
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Costa RM, 2016, VASC PHARMACOL, V84, P28, DOI 10.1016/j.vph.2016.05.008
   Creager MA, 2003, CIRCULATION, V108, P1527, DOI 10.1161/01.CIR.0000091257.27563.32
   da Costa RM, 2017, BRIT J PHARMACOL, V174, P3527, DOI 10.1111/bph.13687
   Du XL, 2001, J CLIN INVEST, V108, P1341, DOI 10.1172/JCI200111235
   Farb MG, 2012, ARTERIOSCL THROM VAS, V32, P467, DOI 10.1161/ATVBAHA.111.235846
   Federici M, 2002, CIRCULATION, V106, P466, DOI 10.1161/01.CIR.0000023043.02648.51
   Fernández-Alfonso MS, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/402053
   Gao YJ, 2007, CURR PHARM DESIGN, V13, P2185
   Gil-Ortega M, 2010, ENDOCRINOLOGY, V151, P3299, DOI 10.1210/en.2009-1464
   Hart GW, 2007, NATURE, V446, P1017, DOI 10.1038/nature05815
   Heath JM, 2014, CIRC RES, V114, P1094, DOI 10.1161/CIRCRESAHA.114.302968
   Jones SP, 2008, CIRCULATION, V117, P1172, DOI 10.1161/CIRCULATIONAHA.107.730515
   King GL, 1996, ANN MED, V28, P427, DOI 10.3109/07853899608999103
   Laczy B, 2009, AM J PHYSIOL-HEART C, V296, pH13, DOI 10.1152/ajpheart.01056.2008
   Landmesser U, 2003, J CLIN INVEST, V111, P1201, DOI 10.1172/JCI200314172
   Lima VV, 2016, CLIN SCI, V130, P871, DOI 10.1042/CS20150777
   Lima VV, 2012, CLIN SCI, V123, P473, DOI 10.1042/CS20110638
   Lima VV, 2009, J AM SOC HYPERTENS, V3, P374, DOI 10.1016/j.jash.2009.09.004
   Lumeng CN, 2007, J CLIN INVEST, V117, P175, DOI 10.1172/JCI29881
   Ma JF, 2013, EXPERT REV PROTEOMIC, V10, P365, DOI 10.1586/14789450.2013.820536
   Ma LQ, 2010, HYPERTENS RES, V33, P446, DOI 10.1038/hr.2010.11
   Mastronardi CA, 2002, P NATL ACAD SCI USA, V99, P5721, DOI 10.1073/pnas.082098499
   Medford HM, 2012, LIFE SCI, V90, P883, DOI 10.1016/j.lfs.2012.04.030
   Meijer RI, 2011, CURR DIABETES REP, V11, P211, DOI 10.1007/s11892-011-0186-y
   Musicki B, 2005, P NATL ACAD SCI USA, V102, P11870, DOI 10.1073/pnas.0502488102
   Okuda T, 2017, BIOCHEM BIOPH RES CO, V487, P76, DOI 10.1016/j.bbrc.2017.04.019
   Pan Y, 2015, EXP CLIN ENDOCR DIAB, V123, P170, DOI 10.1055/s-0034-1395658
   Ribiere C, 1996, BIOCHEM BIOPH RES CO, V222, P706, DOI 10.1006/bbrc.1996.0824
   Silva JF, 2016, FRONT PHYSIOL, V7, DOI 10.3389/fphys.2016.00386
   SUZUKI H, 1995, HYPERTENSION, V25, P1083, DOI 10.1161/01.HYP.25.5.1083
   Szasz T, 2012, CLIN SCI, V122, P1, DOI 10.1042/CS20110151
   Takakura K, 1999, ARCH BIOCHEM BIOPHYS, V369, P197, DOI 10.1006/abbi.1999.1374
   Victorio JA, 2016, FRONT PHYSIOL, V7, DOI 10.3389/fphys.2016.00295
   Vosseller K, 2002, P NATL ACAD SCI USA, V99, P5313, DOI 10.1073/pnas.072072399
   Weber DS, 2004, CIRC RES, V94, P1219, DOI 10.1161/01.RES.0000126848.54740.4A
   Xia N, 2017, BRIT J PHARMACOL, V174, P3425, DOI 10.1111/bph.13650
   Xia N, 2016, ARTERIOSCL THROM VAS, V36, P78, DOI 10.1161/ATVBAHA.115.306263
NR 42
TC 28
Z9 29
U1 1
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD APR 6
PY 2018
VL 9
AR 341
DI 10.3389/fphys.2018.00341
PG 16
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA GB9BV
UT WOS:000429369900001
PM 29681862
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Toblli, JE
   Cao, G
   Angerosa, M
   Rivero, M
AF Toblli, J. E.
   Cao, G.
   Angerosa, M.
   Rivero, M.
TI Long-term phosphodiesterase 5 inhibitor administration reduces
   inflammatory markers and heat-shock proteins in cavernous tissue of
   Zucker diabetic fatty rat (ZDF/fa/fa)
SO INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
LA English
DT Article
ID ERECTILE DYSFUNCTION; METABOLIC SYNDROME; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; NITRIC-OXIDE; ENDOTHELIAL FUNCTION;
   INSULIN-RESISTANCE; CORPORA CAVERNOSA; HYPERTENSIVE-RATS; ACE-INHIBITION
AB Oxidative Stress and nitrosative stress present in type 2 diabetes Mellitus (T2DM) and metabolic syndrome (MS) induce inflammatory response in diverse tissues including cavernous tissue (CT): Heat-Shock proteins (HSPs) have an important role in Modulating and repairing tissue injury, although their participation in CT in T2DM is unclear. Beyond the specific action of phosphodiesterase type 5 inhibitors (PDE5i) on erectile function, it has been proposed that chronic administration of these agents Improves endothelial function and ameliorates fibrotic changes. The aim of this study was to determine in CT of Zucker Diabetic Fatty (ZDF) rat, an experimental model of T2DM and MS: (1) the degree of oxidative stress and nitrosative stress; (2) the magnitude of inflammatory markers such as tumor necrosis factor-alpha (INF alpha) and interleukin 6 (IL6); (3) innmunoexpression of HSP70 and HSP27; (4) how a long-term PDE5i administration may modify these variables, For 6 Months,: (1) untreated ZDF; (2) ZDF+Sildenafil (Sil) and (3) control Lean Zucker Rat (LZR) received no treatment, were studied. Penises were processed for functional 'in vitro' studies, oxidative and nitrosative stress evaluation and Immunohistochemistry in CT using INF alpha; IL6; nitrotyrosine, HSP70 and HSP27 antibodies. ZDF+Sil presented better relaxation in Corporal strips versus untreated ZDF: Furthermore, ZDF+Sil presented less lipoperoxidation in CT versus untreated ZDF. The activity of antioxidant enzymes CuZn superoxide dismutase (CuZnSOD) and, glutathione peroxidase (GPx) was also reduced in untreated ZDF in CT along with a decrease in glutathione versus untreated ZDF. Nittotyrosine expression Was increased in untreated-ZDF rats versus ZDF+Sil and LZR. TNF alpha and IL6 were decreased in CT in ZDF+Sil versus Untreated ZDF. Additionally, the expression of HSP70 and HSP27 was reduced in CT in ZDP+Sil versus untreated ZDF. In Conclusion, this study provides substantial evidence stipporting a protective role a a long-term therapy With Sil on CT in a: recognized animal model of T2DM and MS.
C1 [Toblli, J. E.; Cao, G.; Angerosa, M.; Rivero, M.] Univ Buenos Aires, Expt Med Lab, Hosp Aleman, Sch Med, RA-1118 Buenos Aires, DF, Argentina.
C3 University of Buenos Aires; University of Buenos Aires Hospital;
   Hospital Aleman
RP Toblli, JE (corresponding author), Univ Buenos Aires, Expt Med Lab, Hosp Aleman, Sch Med, Ave Pueyrredon, RA-1118 Buenos Aires, DF, Argentina.
EM jorgetoblli@fibertel.com.ar
RI Cao, Gabriel/LJL-8755-2024
FU University of Buenos Aires (UBA); SLAMS grant
FX JET is a career investigator from Consejo Nacional de Investigaciones
   Cientificas y Tecnologicas of Argentina (CONICET) and received grant
   support from the University of Buenos Aires (UBA). We would like to
   thank to Ana Uceda and Mariana Feldman for their valuable technical
   support in the experiments, and Ms Jaquelina Mastantuono, who gently
   reviewed the style of this manuscript. This study was partially
   supported by the SLAMS grant for basic research.
CR Allen DA, 2005, J NUTR BIOCHEM, V16, P705, DOI 10.1016/j.jnutbio.2005.06.007
   Aversa A, 2006, CURR PHARM DESIGN, V12, P3467, DOI 10.2174/138161206778343046
   Ballard SA, 1998, J UROLOGY, V159, P2164, DOI 10.1016/S0022-5347(01)63299-3
   BEAVO JA, 1995, PHYSIOL REV, V75, P725, DOI 10.1152/physrev.1995.75.4.725
   Behr-Roussel D, 2005, EUR UROL, V47, P87, DOI 10.1016/j.eururo.2004.09.005
   Bivalacqua TJ, 2009, J UROLOGY, V181, P899, DOI 10.1016/j.juro.2008.10.062
   Boolell M, 1996, Int J Impot Res, V8, P47
   BRAY GA, 1977, FED PROC, V36, P148
   Burnett AL, 2009, J UROLOGY, V181, P245, DOI 10.1016/j.juro.2008.09.005
   Burut DFP, 2010, CELL STRESS CHAPERON, V15, P379, DOI 10.1007/s12192-009-0152-7
   Busija D W, 2005, Minerva Med, V96, P223
   Calderwood SK, 2009, GERONTOLOGY, V55, P550, DOI 10.1159/000225957
   Carneiro FS, 2010, J SEX MED, V7, P3823, DOI 10.1111/j.1743-6109.2010.01762.x
   Carneiro FS, 2009, J SEX MED, V6, P311, DOI 10.1111/j.1743-6109.2008.01189.x
   Cernes R, 2008, ADV CARDIOL, V45, P65, DOI 10.1159/000115188
   CHANCE B, 1955, METHOD ENZYMOL, V2, P764, DOI 10.1016/S0076-6879(55)02300-8
   Chen Y, 2012, ASIAN J ANDROL, V14, P616, DOI 10.1038/aja.2012.22
   Du XL, 2003, J CLIN INVEST, V112, P1049, DOI 10.1172/JCI200318127
   Toblli JE, 2006, AM J HYPERTENS, V19, P1226, DOI 10.1016/j.amjhyper.2006.05.016
   Elçioglu HK, 2011, EUR J PHARMACOL, V660, P476, DOI 10.1016/j.ejphar.2011.03.030
   Ferrini MG, 2010, J SEX MED, V7, P3033, DOI 10.1111/j.1743-6109.2010.01884.x
   Giani JF, 2007, AM J PHYSIOL-HEART C, V293, pH1154, DOI 10.1152/ajpheart.01395.2006
   Goldstein I, 1998, NEW ENGL J MED, V338, P1397, DOI 10.1056/NEJM199805143382001
   Grundy SM, 1999, CIRCULATION, V100, P1134, DOI 10.1161/01.CIR.100.10.1134
   Haffner SM, 1998, NEW ENGL J MED, V339, P229, DOI 10.1056/NEJM199807233390404
   Hall L, 2013, SPRINGERPLUS, V2, DOI 10.1186/2193-1801-2-431
   Hayden MR, 2005, CARDIOVASC DIABETOL, V4, DOI 10.1186/1475-2840-4-9
   Heeba G, 2009, BRIT J PHARMACOL, V156, P1256, DOI 10.1111/j.1476-5381.2009.00125.x
   Hotston MR, 2007, BJU INT, V99, P612, DOI 10.1111/j.1464-410X.2006.06618.x
   ISCHIROPOULOS H, 1992, ARCH BIOCHEM BIOPHYS, V298, P446, DOI 10.1016/0003-9861(92)90433-W
   Izzard AS, 2005, J HYPERTENS, V23, P247, DOI 10.1097/00004872-200502000-00002
   KANNEL WB, 1979, JAMA-J AM MED ASSOC, V241, P2035, DOI 10.1001/jama.241.19.2035
   Kava R., 1990, ILAR NEWS, V32, P4, DOI [10.1093/ilar.32.3.4, DOI 10.1093/ILAR.32.3.4]
   KOOY NW, 1994, ARCH BIOCHEM BIOPHYS, V310, P352, DOI 10.1006/abbi.1994.1178
   Kovanecz I, 2009, BJU INT, V103, P1396, DOI 10.1111/j.1464-410X.2008.08251.x
   KURTZ TW, 1989, HYPERTENSION, V13, P896, DOI 10.1161/01.HYP.13.6.896
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   Maiese K, 2007, CURR MED CHEM, V14, P1729
   Marchesini G, 2003, HEPATOLOGY, V37, P917, DOI 10.1053/jhep.2003.50161
   Marques-Vidal P, 2013, CLIN ENDOCRINOL, V78, P232, DOI 10.1111/j.1365-2265.2012.04384.x
   Michel T, 2010, PFLUG ARCH EUR J PHY, V459, P807, DOI 10.1007/s00424-009-0765-9
   Mokini Z, 2010, DIABETES RES CLIN PR, V87, P313, DOI 10.1016/j.diabres.2009.11.018
   Morelli A, 2013, PROSTATE, V73, P428, DOI 10.1002/pros.22584
   Muñoz MC, 2009, J HYPERTENS, V27, P2409, DOI 10.1097/HJH.0b013e3283310e1b
   NIEHAUS WG, 1968, EUR J BIOCHEM, V6, P126, DOI 10.1111/j.1432-1033.1968.tb00428.x
   Pacher P, 2005, ANTIOXID REDOX SIGN, V7, P1568, DOI 10.1089/ars.2005.7.1568
   PAOLETTI F, 1986, ANAL BIOCHEM, V154, P536, DOI 10.1016/0003-2697(86)90026-6
   Rosanoa GMC, 2005, EUR UROL, V47, P214, DOI 10.1016/j.eururo.2004.10.002
   Ryu JK, 2005, UROLOGY, V65, P611, DOI 10.1016/j.urology.2004.10.038
   Schächinger V, 2000, CIRCULATION, V101, P1899, DOI 10.1161/01.CIR.101.16.1899
   Taube A, 2012, AM J PHYSIOL-HEART C, V302, pH2148, DOI 10.1152/ajpheart.00907.2011
   Tobili JE, 2007, J SEX MED, V4, P1291, DOI 10.1111/j.1743-6109.2007.00567.x
   Toblli JE, 2008, OBESITY, V16, P770, DOI 10.1038/oby.2007.114
   Toblli JE, 2007, J SEX MED, V4, P1593, DOI 10.1111/j.1743-6109.2007.00597.x
   Toblli JE, 2006, J NEPHROL, V19, P419
   Toblli JE, 2010, J HYPERTENS, V28, P1007, DOI 10.1097/HJH.0b013e328337598c
   Vignozzi L, 2014, MOL CELL ENDOCRINOL, V384, P143, DOI 10.1016/j.mce.2014.01.014
   Vignozzi L, 2013, PROSTATE, V73, P1391, DOI 10.1002/pros.22686
   Yasmin, 2008, CLIN SCI, V114, P661, DOI 10.1042/CS20070369
NR 59
TC 8
Z9 8
U1 1
U2 7
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0955-9930
EI 1476-5489
J9 INT J IMPOT RES
JI Int. J. Impot. Res.
PD SEP-OCT
PY 2015
VL 27
IS 5
BP 182
EP 190
DI 10.1038/ijir.2015.13
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA CR1IU
UT WOS:000361079200005
PM 26202338
DA 2025-06-11
ER

PT J
AU Kim, JH
   Park, HY
   Bae, S
   Lim, YH
   Hong, YC
AF Kim, Jin Hee
   Park, Hye Yin
   Bae, Sanghyuk
   Lim, Youn-Hee
   Hong, Yun-Chul
TI Diethylhexyl Phthalates Is Associated with Insulin Resistance via
   Oxidative Stress in the Elderly: A Panel Study
SO PLOS ONE
LA English
DT Article
ID IN-UTERO EXPOSURE; DI(2-ETHYLHEXYL) PHTHALATE; TEMPORAL VARIABILITY;
   METABOLIC SYNDROME; NATIONAL-HEALTH; URINE SAMPLES; MISSING DATA; INDOOR
   AIR; MALE RATS; GLUCOSE
AB Background: Insulin resistance (IR) is believed to be the underlying mechanism of metabolic syndrome and type 2 diabetes mellitus (DM). Recently, a few studies have demonstrated that phthalates could cause oxidative stress which would contribute to the development of IR. Therefore, we evaluated whether exposure to phthalates affects IR, and oxidative stress is involved in the phthalates-IR pathway.
   Methods: We recruited 560 elderly participants, and obtained blood and urine samples during repeated medical examinations. For the determination of phthalate exposure, we measured urinary levels of mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) as metabolites of diethylhexyl phthalates (DEHP), and mono-n-butyl phthalate (MnBP) as a metabolite of di-butyl phthalate (DBP). Malondialdehyde (MDA), an oxidative stress biomarker, was also measured in urine samples. We measured serum levels of fasting glucose and insulin, and derived the homeostatic model assessment (HOMA) index to assess IR. A mixed-effect model and penalized regression spline were used to estimate the associations among phthalate metabolites, MDA, and IR.
   Results: The molar sum of MEHHP and MEOHP (Sigma DEHP) were significantly associated with HOMA (beta = 0.26, P = 0.040), and the association was apparent among participants with a history of DM (beta = 0.88, P = 0.037) and among females (beta = 0.30, P = 0.022). However, the relation between MnBP and HOMA was not found. When we evaluated whether oxidative stress is involved in increases of HOMA by Sigma DEHP, MDA levels were significantly associated with increases of Sigma DEHP (beta = 0.11, P < 0.001) and HOMA (beta = 0.49, P = 0.049).
   Conclusions: Our study results suggest that exposure to DEHP in the elderly population increases IR, which is related with oxidative stress, and that participants with a history of DM and females are more susceptible to DEHP exposure.
C1 [Kim, Jin Hee; Hong, Yun-Chul] Seoul Natl Univ, Inst Environm Med, Med Res Ctr, Seoul, South Korea.
   [Kim, Jin Hee; Bae, Sanghyuk; Hong, Yun-Chul] Seoul Natl Univ, Coll Med, Ctr Environm Hlth, Seoul, South Korea.
   [Park, Hye Yin; Bae, Sanghyuk; Hong, Yun-Chul] Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea.
   [Lim, Youn-Hee] Seoul Natl Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Seoul, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU); Seoul
   National University (SNU); Seoul National University (SNU)
RP Hong, YC (corresponding author), Seoul Natl Univ, Inst Environm Med, Med Res Ctr, Seoul, South Korea.
EM ychong1@snu.ac.kr
RI Bae, Sanghyuk/AAQ-6635-2020; kim, jm/O-5935-2014; Hong,
   Yun-Chul/J-5725-2012
OI KIM, JIN HEE/0000-0003-1204-7079; Lim, Youn-Hee/0000-0002-1290-5814;
   Bae, Sanghyuk/0000-0002-4995-6543
FU Ministry of Environment, Republic of Korea
FX This study was supported by the Susceptible Population Research Program
   (2008-2010) of the Ministry of Environment, Republic of Korea. The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
CR Adibi JJ, 2008, ENVIRON HEALTH PERSP, V116, P467, DOI 10.1289/ehp.10749
   ALBRO PW, 1974, J CHROMATOGR, V94, P209, DOI 10.1016/S0021-9673(01)92368-4
   Barr DB, 2003, ENVIRON HEALTH PERSP, V111, P1148, DOI 10.1289/ehp.6074
   Becker K, 2004, INT J HYG ENVIR HEAL, V207, P409, DOI 10.1078/1438-4639-00309
   Brasche S, 2005, INT J HYG ENVIR HEAL, V208, P247, DOI 10.1016/j.ijheh.2005.03.003
   Eckardt Kristin, 2008, Archives of Physiology and Biochemistry, V114, P287, DOI [10.1080/13813450802404761, 10.1080/13813450802404761 ]
   Eriksson JW, 2007, FEBS LETT, V581, P3734, DOI 10.1016/j.febslet.2007.06.044
   Fischer P, 2003, EUR RESPIR J, V21, p34S, DOI 10.1183/09031936.03.00402503
   Fisher JS, 2003, HUM REPROD, V18, P1383, DOI 10.1093/humrep/deg273
   Foster PMD, 2006, INT J ANDROL, V29, P140, DOI 10.1111/j.1365-2605.2005.00563.x
   Frederiksen H, 2007, MOL NUTR FOOD RES, V51, P899, DOI 10.1002/mnfr.200600243
   Fröjdö S, 2009, BBA-MOL BASIS DIS, V1792, P83, DOI 10.1016/j.bbadis.2008.10.019
   Fromme H, 2004, INDOOR AIR, V14, P188, DOI 10.1111/j.1600-0668.2004.00223.x
   Goldstein BJ, 2005, DIABETES, V54, P311, DOI 10.2337/diabetes.54.2.311
   Grattagliano I, 2008, J NUTR BIOCHEM, V19, P491, DOI 10.1016/j.jnutbio.2007.06.011
   Hauser R, 2005, OCCUP ENVIRON MED, V62, DOI 10.1136/oem.2004.017590
   Hauser R, 2004, ENVIRON HEALTH PERSP, V112, P1734, DOI 10.1289/ehp.7212
   Healey N, 2009, RADIAT PROT DOSIM, V134, P143, DOI 10.1093/rpd/ncp068
   Hoang Khiet C, 2007, J Cardiometab Syndr, V2, P276, DOI 10.1111/j.1559-4564.2007.07491.x
   Hong YC, 2009, TOXICOL LETT, V184, P139, DOI 10.1016/j.toxlet.2008.11.001
   Hoppin JA, 2004, ENVIRON HEALTH PERSP, V112, P571, DOI 10.1289/ehp.6564
   Hoppin JA, 2002, ENVIRON HEALTH PERSP, V110, P515, DOI 10.1289/ehp.02110515
   James-Todd T, 2012, ENVIRON HEALTH PERSP, V120, P1307, DOI 10.1289/ehp.1104717
   JANERO DR, 1990, FREE RADICAL BIO MED, V9, P515, DOI 10.1016/0891-5849(90)90131-2
   Jarfelt K, 2005, REPROD TOXICOL, V19, P505, DOI 10.1016/j.reprotox.2004.11.005
   Kim JH, 2012, TOXICOL LETT, V214, P263, DOI 10.1016/j.toxlet.2012.09.006
   Kim JH, 2012, ENVIRON HEALTH PERSP, V120, P1378, DOI 10.1289/ehp.1104406
   Kimber I, 2010, TOXICOLOGY, V271, P73, DOI 10.1016/j.tox.2010.03.020
   Koch HM, 2004, ARCH TOXICOL, V78, P123, DOI 10.1007/00204-003-0522-3
   Lamb RE, 2008, INT J CLIN PRACT, V62, P1087, DOI 10.1111/j.1742-1241.2008.01789.x
   Lara-Castro C, 2008, ENDOCRIN METAB CLIN, V37, P841, DOI 10.1016/j.ecl.2008.09.002
   Latini G, 2006, TOXICOLOGY, V226, P90, DOI 10.1016/j.tox.2006.07.011
   Lim S, 2010, ANN NY ACAD SCI, V1201, P166, DOI 10.1111/j.1749-6632.2010.05622.x
   Lind PM, 2012, DIABETES CARE, V35, P1519, DOI 10.2337/dc11-2396
   Marx J, 2002, SCIENCE, V296, P686, DOI 10.1126/science.296.5568.686
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McKee RH, 2004, REPROD TOXICOL, V18, P1, DOI 10.1016/j.reprotox.2003.09.002
   Moore RW, 2001, ENVIRON HEALTH PERSP, V109, P229, DOI 10.2307/3434690
   Pereira C, 2006, REGUL TOXICOL PHARM, V45, P169, DOI 10.1016/j.yrtph.2006.04.006
   Petersen KF, 2002, AM J CARDIOL, V90, p11G
   Preuss R, 2005, J CHROMATOGR B, V816, P269, DOI 10.1016/j.jchromb.2004.11.048
   ROBINS JM, 1995, J AM STAT ASSOC, V90, P122, DOI 10.2307/2291135
   RUBIN DB, 1976, BIOMETRIKA, V63, P581, DOI 10.2307/2335739
   Rudel RA, 2003, ENVIRON SCI TECHNOL, V37, P4543, DOI 10.1021/es0264596
   Schettler T, 2006, INT J ANDROL, V29, P134, DOI 10.1111/j.1365-2605.2005.00567.x
   Schulz TJ, 2007, CELL METAB, V6, P280, DOI 10.1016/j.cmet.2007.08.011
   Silva MJ, 2006, BIOMARKERS, V11, P1, DOI 10.1080/13547500500382868
   Silva MJ, 2004, B ENVIRON CONTAM TOX, V72, P1226, DOI 10.1007/s00128-004-0374-4
   Silva MJ, 2004, ENVIRON HEALTH PERSP, V112, P331, DOI 10.1289/ehp.6723
   Stahlhut RW, 2007, ENVIRON HEALTH PERSP, V115, P876, DOI 10.1289/ehp.9882
   Svensson K, 2011, ENVIRON RES, V111, P792, DOI 10.1016/j.envres.2011.05.015
   Swan SH, 2005, ENVIRON HEALTH PERSP, V113, P1056, DOI 10.1289/ehp.8100
   Teitelbaum SL, 2008, ENVIRON RES, V106, P257, DOI 10.1016/j.envres.2007.09.010
   WILLIAMS DT, 1975, J AGR FOOD CHEM, V23, P854, DOI 10.1021/jf60201a047
   Wormuth M, 2006, RISK ANAL, V26, P803, DOI 10.1111/j.1539-6924.2006.00770.x
   Zarich S W, 2006, Minerva Cardioangiol, V54, P195
NR 56
TC 102
Z9 113
U1 3
U2 43
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 19
PY 2013
VL 8
IS 8
AR e71392
DI 10.1371/journal.pone.0071392
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 205ER
UT WOS:000323425700045
PM 23977034
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Green, KM
   Choi, JJ
   Ramchandran, RS
   Silverstein, SM
AF Green, Kyle M.
   Choi, Joy J.
   Ramchandran, Rajeev S.
   Silverstein, Steven M.
TI OCT and OCT Angiography Offer New Insights and Opportunities in
   Schizophrenia Research and Treatment
SO FRONTIERS IN DIGITAL HEALTH
LA English
DT Article
DE schizophrenia; OCT; angiography; retina; biomarker
ID NERVE-FIBER LAYER; CARDIOMETABOLIC RISK; THICKNESS; TRAJECTORIES;
   NEUROMOTOR; DISORDERS; STRESS
AB The human retina and retinal imaging technologies continue to increasingly gain the attention of schizophrenia researchers. With the same embryologic origin as the brain, the retina offers a window into neurovascular changes that may underlie disease. Recently, two technologies that have already revolutionized the field of ophthalmology, optical coherence tomography (OCT), and a functional extension of this, optical coherence tomography angiography (OCTA), have gained traction. Together, these non-invasive technologies allow for microscopic imaging of both structural and vascular features of the retina. With ease of use and no side effects, these devices are likely to prove powerful digital health tools in the study and treatment of schizophrenia. They may also prove key to discovering disease relevant biomarkers that underly neurodevelopmental and neurodegenerative aspects of conditions such as schizophrenia.
C1 [Green, Kyle M.; Ramchandran, Rajeev S.; Silverstein, Steven M.] Univ Rochester, Dept Ophthalmol, Med Ctr, Rochester, NY 14642 USA.
   [Choi, Joy J.; Silverstein, Steven M.] Univ Rochester, Dept Psychiat, Med Ctr, Rochester, NY 14642 USA.
   [Ramchandran, Rajeev S.] Univ Rochester, Dept Publ Hlth Sci, Med Ctr, Rochester, NY USA.
   [Silverstein, Steven M.] Univ Rochester, Dept Neurosci, Med Ctr, Rochester, NY 14642 USA.
   [Silverstein, Steven M.] Univ Rochester, Ctr Visual Sci, Rochester, NY 14642 USA.
C3 University of Rochester; University of Rochester; University of
   Rochester; University of Rochester; University of Rochester
RP Silverstein, SM (corresponding author), Univ Rochester, Dept Ophthalmol, Med Ctr, Rochester, NY 14642 USA.; Silverstein, SM (corresponding author), Univ Rochester, Dept Psychiat, Med Ctr, Rochester, NY 14642 USA.; Silverstein, SM (corresponding author), Univ Rochester, Dept Neurosci, Med Ctr, Rochester, NY 14642 USA.; Silverstein, SM (corresponding author), Univ Rochester, Ctr Visual Sci, Rochester, NY 14642 USA.
EM Steven_Silverstein@URMC.rochester.edu
OI Choi, Joy/0000-0003-4343-1356
FU New York Fund for Innovation in Research and Scientific Talent
   (NYFIRST), Center for Eye and Brain Health; Research to Prevent
   Blindness
FX Work on this paper was supported by a grant from the New York Fund for
   Innovation in Research and Scientific Talent (NYFIRST), Center for Eye
   and Brain Health to author SS, as well as an unrestricted grant from
   Research to Prevent Blindness to RR.
CR Abdolahi F, 2021, TRANSL VIS SCI TECHN, V10, DOI 10.1167/tvst.10.9.5
   Appaji A, 2019, BIPOLAR DISORD, V21, P634, DOI 10.1111/bdi.12779
   Ascaso FJ, 2015, PSYCHIAT RES, V229, P230, DOI 10.1016/j.psychres.2015.07.028
   Ashimatey BS, 2020, ALZH DEMENT-DADM, V12, DOI 10.1002/dad2.12071
   Aumann S, 2019, High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics Internet
   Bannai D, 2022, SCHIZOPHRENIA BULL, V48, P80, DOI 10.1093/schbul/sbab111
   Budakoglu O, 2021, CLIN EXP OPTOM, V104, P788, DOI 10.1080/08164622.2021.1878816
   Chen Q, 2021, TRANSL VIS SCI TECHN, V10, DOI 10.1167/tvst.10.6.6
   Choi JA, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0174377
   Chu ZD, 2016, J BIOMED OPT, V21, DOI 10.1117/1.JBO.21.6.066008
   Correll CU, 2014, JAMA PSYCHIAT, V71, P1350, DOI 10.1001/jamapsychiatry.2014.1314
   Cuthbert BN, 2010, SCHIZOPHRENIA BULL, V36, P1061, DOI 10.1093/schbul/sbq108
   De Hert M, 2011, BRIT J PSYCHIAT, V199, P99, DOI 10.1192/bjp.bp.110.084665
   Gagné AM, 2020, SCHIZOPHR RES, V219, P19, DOI 10.1016/j.schres.2019.06.021
   Galderisi S, 2022, SCHIZOPHR RES, V242, P30, DOI 10.1016/j.schres.2021.12.007
   Green KM, 2020, J VITREORETINAL DIS, V4, P499, DOI 10.1177/2474126420936199
   Guo F, 2019, J PSYCHIATR RES, V116, P126, DOI 10.1016/j.jpsychires.2019.06.009
   Hanson DR, 2005, BMC MED GENET, V6, DOI 10.1186/1471-2350-6-7
   Hebert M., 2022, SCHIZOPHRENIA B OPEN
   Hébert M, 2020, BIOL PSYCHIAT, V87, P263, DOI 10.1016/j.biopsych.2019.06.014
   Hébert M, 2017, PROG NEURO-PSYCHOPH, V75, P10, DOI 10.1016/j.pnpbp.2016.12.002
   Hennekens CH, 2005, AM HEART J, V150, P1115, DOI 10.1016/j.ahj.2005.02.007
   Ho AC, 2021, J CLIN MED, V10, DOI 10.3390/jcm10071355
   Holtzman CW, 2013, NEUROSCIENCE, V249, P172, DOI 10.1016/j.neuroscience.2012.12.017
   Islam MA, 2018, ACTA PSYCHIAT SCAND, V138, P591, DOI 10.1111/acps.12961
   Jiang H, 2020, AM J OPHTHALMOL, V213, P34, DOI 10.1016/j.ajo.2019.12.021
   Kim AY, 2016, INVEST OPHTH VIS SCI, V57, pOCT362, DOI 10.1167/iovs.15-18904
   Koman-Wierdak E, 2021, J CLIN MED, V10, DOI 10.3390/jcm10184131
   Lai A., 2020, Biomark Neuropsychiatry, V2, DOI DOI 10.1016/J.BIONPS.2020.100013
   Laursen TM, 2012, CURR OPIN PSYCHIATR, V25, P83, DOI 10.1097/YCO.0b013e32835035ca
   Le D, 2021, EXP BIOL MED, V246, P2170, DOI 10.1177/15353702211026581
   Maloca P, 2018, TRANSL VIS SCI TECHN, V7, DOI 10.1167/tvst.7.4.8
   MANSOUR AM, 1993, RETINA-J RET VIT DIS, V13, P125, DOI 10.1097/00006982-199313020-00006
   McGrath J, 2008, EPIDEMIOL REV, V30, P67, DOI 10.1093/epirev/mxn001
   Meier MH, 2016, CURR PSYCHIATRY REV, V12, P326, DOI 10.2174/1573400512666160927145417
   Moises HW, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.103
   Nishanth KN, 2017, INDIAN J MED RES, V146, P281, DOI 10.4103/ijmr.IJMR_1510_15
   Ouellette J, 2021, FRONT AGING NEUROSCI, V13, DOI 10.3389/fnagi.2021.749026
   Pruessner M, 2017, NEUROSCI BIOBEHAV R, V73, P191, DOI 10.1016/j.neubiorev.2016.12.013
   Rogaczewska M, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0253417
   Sahin OZ, 2015, BLOOD PRESSURE, V24, P178, DOI 10.3109/08037051.2014.1000562
   Schenkel LS, 2004, GENET SOC GEN PSYCH, V130, P241, DOI 10.3200/MONO.130.3.241-272
   Schiffman J, 2004, AM J PSYCHIAT, V161, P2021, DOI 10.1176/appi.ajp.161.11.2021
   Schwartz GW, 2021, Retinal computation
   Shmukler AB, 2015, EUR PSYCHIAT, V30, P1002, DOI 10.1016/j.eurpsy.2015.08.005
   Silverstein SM., 2020, Bio Neuropsych, V2, DOI DOI 10.1016/J.BIONPS.2020.100018
   Silverstein SM, 2021, EYE BRAIN, V13, P205, DOI 10.2147/EB.S317186
   Silverstein SM, 2021, NPJ SCHIZOPHR, V7, DOI 10.1038/s41537-021-00156-1
   Silverstein SM, 2020, SCHIZOPHR RES, V219, P84, DOI 10.1016/j.schres.2019.09.016
   Silverstein SM, 2018, PSYCHOL MED, V48, P2023, DOI 10.1017/S0033291717003555
   Sweeting J, 2013, SCHIZOPHR RES, V150, P398, DOI 10.1016/j.schres.2013.08.029
   Tian JQ, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-020-80312-2
   Velthorst E, 2017, AM J PSYCHIAT, V174, P1075, DOI 10.1176/appi.ajp.2016.15111419
   Vetter MW, 2015, NPJ SCHIZOPHR, V1, DOI 10.1038/npjschz.2015.23
   Wadhwani M, 2015, J GLAUCOMA, V24, pe109, DOI 10.1097/IJG.0000000000000203
   Wong SE, 2014, RES SOCIAL WORK PRAC, V24, P132, DOI 10.1177/1049731513505152
   Zhang Q, 2021, NEUROPSYCH DIS TREAT, V17, P3267, DOI 10.2147/NDT.S333833
   Zhuo CJ, 2020, PSYCHIAT RES, V286, DOI 10.1016/j.psychres.2020.112906
NR 58
TC 6
Z9 8
U1 0
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2673-253X
J9 FRONT DIGIT HEALTH
JI Front. Digit. Health
PD FEB 18
PY 2022
VL 4
AR 836851
DI 10.3389/fdgth.2022.836851
PG 7
WC Health Care Sciences & Services; Medical Informatics
WE Emerging Sources Citation Index (ESCI)
SC Health Care Sciences & Services; Medical Informatics
GA M9FN0
UT WOS:001033199000001
PM 35252961
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vogel, M
   Braungardt, T
   Meyer, W
   Schneider, W
AF Vogel, Matthias
   Braungardt, Tanja
   Meyer, Wolfgang
   Schneider, Wolfgang
TI The effects of shift work on physical and mental health
SO JOURNAL OF NEURAL TRANSMISSION
LA English
DT Review
DE Shift work; Desynchronization of circadian rhythms; Melatonin;
   Psychosocial implications of the working schedule
ID ISCHEMIC-HEART-DISEASE; PROSPECTIVE COHORT; METABOLIC SYNDROME; JOB
   DEMANDS; GASTROINTESTINAL DISORDERS; EXOGENOUS MELATONIN;
   DIABETES-MELLITUS; DECISION LATITUDE; EMPLOYMENT STATUS; SLEEP DISORDERS
AB Occupational engagement is a pre-requisite for continuous income opportunities. Among the changing social circumstances work-related conditions play an increasingly eminent role in psychological and mental well-being. The public discusses the question of a possible association between the demands of modern work life and the increases of psychological, psychosomatic and cardiovascular disorders. Given the socioeconomic implications of psychiatric and psychosomatic suffering in the general population, there is a need to further elucidate the causes of their increasing incidence. From a medical point of view, any organization of work disrupting the phased circadian rhythms for bio-psycho-social processes and functioning of the individual are interesting against the background of clock genes and certain biological functions that are organized in a circadian fashion. The authors review the influence of shift work as a form of systematic desynchronization of inner clock systems on the endocrine, the physical, and the mental level. The significance of the findings in the field is discussed along with future directions of conclusive research.
C1 [Vogel, Matthias; Braungardt, Tanja; Meyer, Wolfgang; Schneider, Wolfgang] Univ Rostock, Dept Psychosomat Med & Psychotherapy, D-18147 Rostock, Germany.
C3 University of Rostock
RP Schneider, W (corresponding author), Univ Rostock, Dept Psychosomat Med & Psychotherapy, Gehlsheimer Str 20, D-18147 Rostock, Germany.
EM wolfgang.schneider@med.uni-rostock.de
RI Vogel, Matthias/AAG-2529-2019
CR Ahola K, 2007, J AFFECT DISORDERS, V104, P103, DOI 10.1016/j.jad.2007.03.004
   AKERSTEDT T, 1990, SCAND J WORK ENV HEA, V16, P67, DOI 10.5271/sjweh.1819
   Åkerstedt T, 2003, OCCUP MED-OXFORD, V53, P89, DOI 10.1093/occmed/kqg046
   Åkerstedt T, 2008, CHRONOBIOL INT, V25, P333, DOI 10.1080/07420520802113922
   Åkerstedt T, 2009, SLEEP MED CLIN, V4, P257, DOI 10.1016/j.jsmc.2009.03.001
   ALFREDSSON L, 1991, ERGONOMICS, V34, P525, DOI 10.1080/00140139108967334
   Angerer P., 2010, SomnologieSchlafforschung und Schlafmedizin, V14, P88, DOI [10.1007/s11818-010-0462-0, DOI 10.1007/S11818-010-0462-0]
   ANGERSBACH D, 1980, INT ARCH OCC ENV HEA, V45, P127, DOI 10.1007/BF01274132
   [Anonymous], 2005, The International Classification of Sleep Disorders, V2nd
   ARANA GW, 1985, ARCH GEN PSYCHIAT, V42, P1193
   Ardekani Z Zamanian, 2008, Pak J Biol Sci, V11, P1605, DOI 10.3923/pjbs.2008.1605.1609
   ARNETZ BB, 1991, PSYCHOTHER PSYCHOSOM, V55, P76, DOI 10.1159/000288412
   Bara AC, 2009, SCAND J WORK ENV HEA, V35, P361, DOI 10.5271/sjweh.1344
   Barnes-Farrell JL, 2008, APPL ERGON, V39, P589, DOI 10.1016/j.apergo.2008.02.019
   Bebbington P E, 1999, J Gend Specif Med, V2, P52
   Beermann B, 2010, 2009 FEHLZEITEN, P71
   Boggild H, 1996, INT J EPIDEMIOL, V25, P630, DOI 10.1093/ije/25.3.630
   Boscolo P, 2011, INT J IMMUNOPATH PH, V24, P51
   Bosma H, 1998, AM J PUBLIC HEALTH, V88, P68, DOI 10.2105/AJPH.88.1.68
   Buscemi N, 2006, BMJ-BRIT MED J, V332, P385, DOI 10.1136/bmj.38731.532766.F6
   Buscemi N, 2005, J GEN INTERN MED, V20, P1151, DOI 10.1111/j.1525-1497.2005.0243.x
   Campino C, 2008, REV MED CHILE, V136, P1390
   Conlon M, 2007, EPIDEMIOLOGY, V18, P182, DOI 10.1097/01.ede.0000249519.33978.31
   Costa G, 2004, CHRONOBIOL INT, V21, P831, DOI 10.1081/CBI-200035935
   Culpepper L, 2010, J FAM PRACTICE, V59, pS3
   De Bacquer D, 2005, AM J EPIDEMIOL, V161, P434, DOI 10.1093/aje/kwi040
   Derogatis L.R. Unger., 2010, SYMPTOM CHECKLIST 90
   DIRKEN JM, 1966, ERGONOMICS, V9, P115, DOI 10.1080/00140136608964357
   Drake CL, 2004, SLEEP, V27, P1453, DOI 10.1093/sleep/27.8.1453
   Driesen K, 2011, SCAND J WORK ENV HEA, V37, P402, DOI 10.5271/sjweh.3158
   Eaker ED, 2004, AM J EPIDEMIOL, V159, P950, DOI 10.1093/aje/kwh127
   Elenkov IJ, 2002, ANN NY ACAD SCI, V966, P290, DOI 10.1111/j.1749-6632.2002.tb04229.x
   Fellerhoff B, 2007, MOL PSYCHIATR, V12, P264, DOI 10.1038/sj.mp.4001925
   Folkard S, 2003, OCCUP MED-OXFORD, V53, P95, DOI 10.1093/occmed/kqg047
   Folkard S, 2004, AVIAT SPACE ENVIR MD, V75, pA161
   Frost P, 2009, SCAND J WORK ENV HEA, V35, P163, DOI 10.5271/sjweh.1319
   Godin I, 2005, BMC PUBLIC HEALTH, V5, DOI 10.1186/1471-2458-5-67
   Harrington JM, 2001, OCCUP ENVIRON MED, V58, P68, DOI 10.1136/oem.58.1.68
   Hermansson J, 2007, SCAND J WORK ENV HEA, V33, P435, DOI 10.5271/sjweh.1165
   Higashi T, 1988, Asia Pac J Public Health, V2, P112
   Hill SM, 2011, J MAMMARY GLAND BIOL, V16, P235, DOI 10.1007/s10911-011-9222-4
   Hoogerwerf WA, 2007, GASTROENTEROLOGY, V133, P1250, DOI 10.1053/j.gastro.2007.07.009
   Kantermann T, 2010, SLEEP BIOL RHYTHMS, V8, P95, DOI 10.1111/j.1479-8425.2010.00432.x
   KARASEK RA, 1979, ADMIN SCI QUART, V24, P285, DOI 10.2307/2392498
   Karasek RA, 1990, Healthy work: Stress, productivity, and the reconstruction of working life
   Karlsson B, 2005, SCAND J WORK ENV HEA, V31, P30, DOI 10.5271/sjweh.845
   Karlsson B, 2001, OCCUP ENVIRON MED, V58, P747, DOI 10.1136/oem.58.11.747
   Kawakami N, 1999, J EPIDEMIOL COMMUN H, V53, P359, DOI 10.1136/jech.53.6.359
   Kennedy SH, 2006, EUR NEUROPSYCHOPHARM, V16, P93, DOI 10.1016/j.euroneuro.2005.09.002
   Kino T, 2011, MOL CELL ENDOCRINOL, V336, P23, DOI 10.1016/j.mce.2010.12.001
   Kivimäki M, 2007, OCCUP ENVIRON MED, V64, P659, DOI 10.1136/oem.2006.031310
   Kivimäki M, 2011, PLOS MED, V8, DOI 10.1371/journal.pmed.1001138
   Kivimäki M, 2002, BRIT MED J, V325, P857, DOI 10.1136/bmj.325.7369.857
   Knutson A, 2010, SCAND J WORK ENV HEA, V36, P85, DOI 10.5271/sjweh.2897
   Knutsson A, 1989, Scand J Soc Med Suppl, V44, P1
   Knutsson A, 2003, OCCUP MED-OXFORD, V53, P103, DOI 10.1093/occmed/kqg048
   Kojima S, 2011, BRIT J PHARMACOL, V162, P1179, DOI 10.1111/j.1476-5381.2010.01122.x
   KOLLER M, 1978, ERGONOMICS, V21, P835, DOI 10.1080/00140137808931787
   Kubo T, 2006, AM J EPIDEMIOL, V164, P549, DOI 10.1093/aje/kwj232
   Kuper H, 2003, J EPIDEMIOL COMMUN H, V57, P147, DOI 10.1136/jech.57.2.147
   Kuper Hannah, 2002, Semin Vasc Med, V2, P267, DOI 10.1055/s-2002-35401
   Lahti TA, 2008, INT J CANCER, V123, P2148, DOI 10.1002/ijc.23566
   Li YM, 2008, J GASTROEN HEPATOL, V23, P283, DOI 10.1111/j.1440-1746.2007.05045.x
   Lin YC, 2009, WORLD J GASTROENTERO, V15, P5654, DOI 10.3748/wjg.15.5654
   Lin YC, 2009, CHRONOBIOL INT, V26, P740, DOI 10.1080/07420520902929029
   Lindberg G, 1996, SCAND J GASTROENTERO, V31, P658, DOI 10.3109/00365529609009146
   Lu WZ, 2006, EUR J GASTROEN HEPAT, V18, P623, DOI 10.1097/00042737-200606000-00008
   Mausner-Dorsch H, 2000, AM J PUBLIC HEALTH, V90, P1765, DOI 10.2105/AJPH.90.11.1765
   Mediavilla MD, 2010, CURR MED CHEM, V17, P4462, DOI 10.2174/092986710794183015
   MIKUNI E, 1983, Tohoku Journal of Experimental Medicine, V141, P251
   Mitchell HA, 2010, BIOCHEM PHARMACOL, V79, P801, DOI 10.1016/j.bcp.2009.10.004
   Moore J G, 1970, Nature, V226, P1261, DOI 10.1038/2261261a0
   MOORE JG, 1974, DIGESTION, V11, P226, DOI 10.1159/000197586
   MOORE JG, 1973, DIGESTION, V9, P97, DOI 10.1159/000197435
   Morikawa Y, 2005, SCAND J WORK ENV HEA, V31, P179, DOI 10.5271/sjweh.867
   Nakata A, 2011, J CLIN PSYCHIAT, V72, P605, DOI 10.4088/JCP.10m06397gry
   Netterstrom B, 2006, EUR J CARDIOV PREV R, V13, P414, DOI 10.1097/00149831-200606000-00018
   Nicholson PJ, 1999, OCCUP MED-OXFORD, V49, P127, DOI 10.1093/occmed/49.3.127
   Niu SF, 2011, J NURS RES, V19, P68, DOI 10.1097/JNR.0b013e31820c1879
   Pandi-Perumal SR, 2007, CNS DRUGS, V21, P995, DOI 10.2165/00023210-200721120-00004
   Parent-Thirion A., 2007, Fourth European Working Conditions Survey, P1
   Pariante CM, 2009, ANN NY ACAD SCI, V1179, P144, DOI 10.1111/j.1749-6632.2009.04978.x
   Pariante Carmine M, 2008, J Psychopharmacol, V22, P76, DOI 10.1177/0269881107084020
   Peter R, 1999, SCAND J WORK ENV HEA, V25, P376, DOI 10.5271/sjweh.448
   Pietroiusti A, 2010, OCCUP ENVIRON MED, V67, P54, DOI 10.1136/oem.2009.046797
   Pilcher JJ, 2000, SLEEP, V23, P155
   Prunier-Poulmaire S, 1998, SCAND J WORK ENV HEA, V24, P134
   Rahman SA, 2010, EUR ARCH PSY CLIN N, V260, P327, DOI 10.1007/s00406-009-0080-7
   Roenneberg T, 2003, J BIOL RHYTHM, V18, P80, DOI 10.1177/0748730402239679
   RUTENFRANZ J, 1977, SCAND J WORK ENV HEA, V3, P165, DOI 10.5271/sjweh.2777
   Schernhammer ES, 2003, JNCI-J NATL CANCER I, V95, P825, DOI 10.1093/jnci/95.11.825
   Schneider W, 2011, PSYCHOTHERAPEUT, V56, P8, DOI 10.1007/s00278-010-0792-1
   Schwartz JRL, 2006, DRUGS, V66, P2357, DOI 10.2165/00003495-200666180-00007
   Schwartzbaum J, 2007, SCAND J WORK ENV HEA, V33, P336, DOI 10.5271/sjweh.1150
   Schwarz MJ, 2001, BRAIN BEHAV IMMUN, V15, P340, DOI 10.1006/brbi.2001.0647
   Selvi Y, 2010, DUNSEN ADAM, V23, P238, DOI 10.5350/DAJPN2010230403
   Siegrist J, 1996, J Occup Health Psychol, V1, P27, DOI 10.1037/1076-8998.1.1.27
   SIEGRIST J, 1990, SOC SCI MED, V31, P1127, DOI 10.1016/0277-9536(90)90234-J
   Son GH, 2011, FRONT NEUROENDOCRIN, V32, P451, DOI 10.1016/j.yfrne.2011.07.003
   STAINES GL, 1986, J OCCUP BEHAV, V7, P147, DOI 10.1002/job.4030070207
   Sugisawa A, 1998, J OCCUP HEALTH, V40, P22, DOI 10.1539/joh.40.22
   Takeyama H, 2004, REV SAUDE PUBL, V38, P32, DOI 10.1590/S0034-89102004000700006
   Tamura H, 2008, REPROD TOXICOL, V25, P291, DOI 10.1016/j.reprotox.2008.03.005
   TARQUINI B, 1986, INT ARCH OCC ENV HEA, V58, P99, DOI 10.1007/BF00380760
   Terry PD, 2009, INFLAMM BOWEL DIS, V15, P134, DOI 10.1002/ibd.20527
   TUCHSEN F, 1994, INT J EPIDEMIOL, V23, P365, DOI 10.1093/ije/23.2.365
   Ursin R, 2002, SLEEP MED REV, V6, P57, DOI 10.1053/smrv.2001.0174
   van Boven K, 2011, BRIT J GEN PRACT, V61, DOI 10.3399/bjgp11X577981
   Vegso S, 2007, AM J IND MED, V50, P597, DOI 10.1002/ajim.20486
   Virtanen M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030719
   Vogel M, 2006, MED HYPOTHESES, V67, P354, DOI 10.1016/j.mehy.2006.01.044
   Walker, 1985, HOURS WORK TEMPORAL, P221
   Wang XS, 2011, OCCUP MED-OXFORD, V61, P78, DOI 10.1093/occmed/kqr001
   Westerberg L, 1997, SCAND J PRIM HEALTH, V15, P76, DOI 10.3109/02813439709018491
   Wittchen HU, 2005, EUR NEUROPSYCHOPHARM, V15, P357, DOI 10.1016/j.euroneuro.2005.04.012
   Ylipaavalniemi J, 2005, SOC SCI MED, V61, P111, DOI 10.1016/j.socscimed.2004.11.038
   Zober A, 1998, J OCCUP ENVIRON MED, V40, P586, DOI 10.1097/00043764-199807000-00002
NR 117
TC 128
Z9 149
U1 0
U2 81
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0300-9564
EI 1435-1463
J9 J NEURAL TRANSM
JI J. Neural Transm.
PD OCT
PY 2012
VL 119
IS 10
SI SI
BP 1121
EP 1132
DI 10.1007/s00702-012-0800-4
PG 12
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 011RS
UT WOS:000309183200008
PM 22488445
DA 2025-06-11
ER

PT J
AU Rotenberg, S
   McGrath, JJ
AF Rotenberg, Sivan
   McGrath, Jennifer J.
TI Inter-relation between autonomic and HPA axis activity in children and
   adolescents
SO BIOLOGICAL PSYCHOLOGY
LA English
DT Article
DE Autonomic nervous system; Heart rate variability;
   Hypothalamic-pituitary-adrenal axis; Diurnal cortisol profile; Children;
   Adolescents; Perceived stress
ID HEART-RATE-VARIABILITY; CORTICOTROPIN-RELEASING HORMONE; SALIVARY
   CORTISOL; NEUROVISCERAL INTEGRATION; METHODOLOGICAL ISSUES; METABOLIC
   SYNDROME; IMMUNE-RESPONSES; FREQUENCY-DOMAIN; ALPHA-AMYLASE; VAGAL TONE
AB Stress research in youth typically considers either the autonomic nervous system or HPA axis. However, these systems are highly coordinated and physically interconnected. We examined whether the interrelation between cardio-autonomic and HPA axis measures was better associated with perceived stress than their singular associations. Children and adolescents (N=201) collected saliva samples to measure cortisol (AUC(AG), AUC(I), maximum), wore an electrocardiogram monitor for 24 h to derive heart rate variability (HRV; LF, HF, LF/HF ratio), and completed the Perceived Stress Scale. The interaction between sympathovagal modulation (LF, LF/HF ratio) and cortisol awakening response (AUC(AG), AUC(I), maximum) explained significantly greater variance in perceived stress than either stress system alone. Higher sympathovagal modulation combined with higher cortisol awakening response was associated with greater perceived stress. Findings suggest that the inter-relation between cardio-autonomic and HPA axis activity may advance our understanding of how stress impacts health. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Rotenberg, Sivan; McGrath, Jennifer J.] Concordia Univ, Montreal, PQ H4B 1R6, Canada.
C3 Concordia University - Canada
RP McGrath, JJ (corresponding author), Concordia Univ, Pediat Publ Hlth Psychol Lab, Dept Psychol, 7141 Sherbrooke St West, Montreal, PQ H4B 1R6, Canada.
EM jennifer.mcgrath@concordia.ca
OI McGrath, Jennifer/0000-0003-1999-5047
FU Canadian Institutes of Health Research (CIHR) [MOP89886, OCO79897]; New
   Investigator Award [MSH95353]; Canada Graduate Scholarships Master's
   Award; Health Professional Student Research Award
FX We thank the participants and their families of the Healthy Heart
   Project, the teachers and principals of the Montreal English School
   Board, and the research assistants and study coordinators of the
   Pediatric Public Health Psychology Laboratory at Concordia University.
   Special thanks to Natasha Hunt, Sabrina Giovanniello, and Neressa Noel
   for their continued dedication. This work was made possible through
   funding support from the Canadian Institutes of Health Research (CIHR)
   Operating Grants (MOP89886 and OCO79897), New Investigator Award (J.J.
   McGrath MSH95353), Canada Graduate Scholarships Master's Award (S.
   Rotenberg), and Health Professional Student Research Award (S.
   Rotenberg).
CR Adam EK, 2006, PSYCHONEUROENDOCRINO, V31, P664, DOI 10.1016/j.psyneuen.2006.01.010
   Adam EK, 2010, PSYCHONEUROENDOCRINO, V35, P921, DOI 10.1016/j.psyneuen.2009.12.007
   Adam EK, 2009, PSYCHONEUROENDOCRINO, V34, P1423, DOI 10.1016/j.psyneuen.2009.06.011
   Aiken LS., 1991, Multiple regression: Testing and interpreting interactions
   Bauer AM, 2002, J DEV BEHAV PEDIATR, V23, P102, DOI 10.1097/00004703-200204000-00007
   BENARROCH EE, 1993, MAYO CLIN PROC, V68, P988, DOI 10.1016/S0025-6196(12)62272-1
   Bengel FM, 2004, J NUCL CARDIOL, V11, P603, DOI 10.1016/j.nuclcard.2004.06.133
   Berntson GG, 2004, DYNAMIC ELECTROCARDIOGRAPHY, P57, DOI 10.1002/9780470987483.ch7
   Berntson GG, 1997, PSYCHOPHYSIOLOGY, V34, P623, DOI 10.1111/j.1469-8986.1997.tb02140.x
   Bevans K, 2008, DEV PSYCHOPATHOL, V20, P257, DOI 10.1017/S0954579408000126
   Björntorp P, 2000, BLOOD PRESSURE, V9, P71, DOI 10.1080/08037050050151762
   Blair C, 2004, DEV PSYCHOBIOL, V45, P113, DOI 10.1002/dev.20022
   CACIOPPO JT, 1995, PSYCHOSOM MED, V57, P154, DOI 10.1097/00006842-199503000-00008
   CACIOPPO JT, 1994, PSYCHOPHYSIOLOGY, V31, P586, DOI 10.1111/j.1469-8986.1994.tb02351.x
   Camm AJ, 1996, EUR HEART J, V17, P354
   Clements AD, 1998, PSYCHONEUROENDOCRINO, V23, P613
   Clow A, 2004, STRESS, V7, P29, DOI 10.1080/10253890410001667205
   Clow A, 2010, NEUROSCI BIOBEHAV R, V35, P97, DOI 10.1016/j.neubiorev.2009.12.011
   Cohen S, 2006, PSYCHOSOM MED, V68, P41, DOI 10.1097/01.psy.0000195967.51768.ea
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   COHEN S, 1988, CLAR SYMP, P31
   Curtis AL, 1997, J PHARMACOL EXP THER, V281, P163
   Cymerblit-Sabba A, 2015, PSYCHONEUROENDOCRINO, V52, P168, DOI 10.1016/j.psyneuen.2014.11.012
   Danese A, 2012, PHYSIOL BEHAV, V106, P29, DOI 10.1016/j.physbeh.2011.08.019
   de Geus E., 2014, S COND M AM PSYCH SO
   Del Giudice M, 2011, NEUROSCI BIOBEHAV R, V35, P1562, DOI 10.1016/j.neubiorev.2010.11.007
   DeSantis AS, 2010, INT J BEHAV MED, V17, P74, DOI 10.1007/s12529-009-9053-5
   Dockray S, 2008, PSYCHONEUROENDOCRINO, V33, P77, DOI 10.1016/j.psyneuen.2007.10.001
   Dreger LC, 2010, J ALLERGY CLIN IMMUN, V125, P116, DOI 10.1016/j.jaci.2009.09.051
   DRESSENDORFER RA, 1992, J STEROID BIOCHEM, V43, P683, DOI 10.1016/0960-0760(92)90294-S
   Egliston KA, 2007, PSYCHONEUROENDOCRINO, V32, P1, DOI 10.1016/j.psyneuen.2006.10.003
   El-Sheikh M, 2008, J ABNORM CHILD PSYCH, V36, P601, DOI 10.1007/s10802-007-9204-6
   El-Sheikh M, 2011, PHYSIOL BEHAV, V103, P225, DOI 10.1016/j.physbeh.2011.02.004
   Engeland WC, 2005, ENDOCRINE, V28, P325, DOI 10.1385/ENDO:28:3:325
   Finkelstein DM, 2007, J ADOLESCENT HEALTH, V40, P127, DOI 10.1016/j.jadohealth.2006.10.006
   Friedman BH, 2007, BIOL PSYCHOL, V74, P185, DOI 10.1016/j.biopsycho.2005.08.009
   Fries E, 2009, INT J PSYCHOPHYSIOL, V72, P67, DOI 10.1016/j.ijpsycho.2008.03.014
   Fuligni AJ, 2009, PSYCHOSOM MED, V71, P329, DOI 10.1097/PSY.0b013e3181921b1f
   Gianaros PJ, 2004, PSYCHOPHYSIOLOGY, V41, P521, DOI 10.1111/1469-8986.2004.00179.x
   Golding J, 2001, PAEDIATR PERINAT EP, V15, P74
   Goodman E, 2005, PSYCHOSOM MED, V67, P9, DOI 10.1097/01.psy.0000149254.36133.1a
   Gordis EB, 2006, PSYCHONEUROENDOCRINO, V31, P976, DOI 10.1016/j.psyneuen.2006.05.010
   Heathers JAJ, 2014, FRONT PHYSIOL, V5, DOI 10.3389/fphys.2014.00177
   Herman JP, 2005, PROG NEURO-PSYCHOPH, V29, P1201, DOI 10.1016/j.pnpbp.2005.08.006
   Hertzman C, 1999, ANN NY ACAD SCI, V896, P85, DOI 10.1111/j.1749-6632.1999.tb08107.x
   Itoi K, 2004, J NEUROENDOCRINOL, V16, P348, DOI 10.1111/j.0953-8194.2004.01172.x
   Jarrin DC, 2015, PEDIATR CARDIOL, V36, P41, DOI 10.1007/s00246-014-0962-y
   Jedema HP, 2004, J NEUROSCI, V24, P9703, DOI 10.1523/JNEUROSCI.2830-04.2004
   Kazuma N, 1997, CHRONOBIOL INT, V14, P597, DOI 10.3109/07420529709001450
   Lahiri MK, 2008, J AM COLL CARDIOL, V51, P1725, DOI 10.1016/j.jacc.2008.01.038
   Looser RR, 2010, PSYCHOSOM MED, V72, P281, DOI 10.1097/PSY.0b013e3181d35065
   Lovell B, 2011, HORM BEHAV, V60, P301, DOI 10.1016/j.yhbeh.2011.06.007
   Lucini D, 2005, HYPERTENSION, V46, P1201, DOI 10.1161/01.HYP.0000185147.32385.4b
   Lupien SJ, 2001, DEV PSYCHOPATHOL, V13, P653, DOI 10.1017/S0954579401003133
   Lupien SJ, 2009, NAT REV NEUROSCI, V10, P434, DOI 10.1038/nrn2639
   Ma S, 2005, J NEUROENDOCRINOL, V17, P761, DOI 10.1111/j.1365-2826.2005.01372.x
   Maldonado EF, 2008, SPAN J PSYCHOL, V11, P3, DOI 10.1017/S1138741600004066
   Malliani A, 1999, NEWS PHYSIOL SCI, V14, P111, DOI 10.1152/physiologyonline.1999.14.3.111
   Malliani Alberto, 2005, Eur J Intern Med, V16, P12, DOI 10.1016/j.ejim.2004.06.016
   McKnight PE, 2007, Missing data a gentle introduction
   Montano N, 2009, NEUROSCI BIOBEHAV R, V33, P71, DOI 10.1016/j.neubiorev.2008.07.006
   MORRIS NM, 1980, J YOUTH ADOLESCENCE, V9, P271, DOI 10.1007/BF02088471
   Nagai N, 2003, OBES RES, V11, P25, DOI 10.1038/oby.2003.6
   Netherton C, 2004, PSYCHONEUROENDOCRINO, V29, P125, DOI 10.1016/S0306-4530(02)00150-6
   Niskanen JP, 2004, COMPUT METH PROG BIO, V76, P73, DOI 10.1016/j.cmpb.2004.03.004
   Oldehinkel AJ, 2011, PSYCHOPHYSIOLOGY, V48, P441, DOI 10.1111/j.1469-8986.2010.01118.x
   Polanczyk CA, 1998, EUR J APPL PHYSIOL O, V79, P69, DOI 10.1007/s004210050475
   Porges SW, 2007, BIOL PSYCHOL, V74, P116, DOI 10.1016/j.biopsycho.2006.06.009
   PORGES SW, 1995, NEUROSCI BIOBEHAV R, V19, P225, DOI 10.1016/0149-7634(94)00066-A
   Pruessner JC, 2003, PSYCHONEUROENDOCRINO, V28, P916, DOI 10.1016/S0306-4530(02)00108-7
   Pumprla J, 2002, INT J CARDIOL, V84, P1, DOI 10.1016/S0167-5273(02)00057-8
   Radley JJ, 2006, J NEUROSCI, V26, P12967, DOI 10.1523/JNEUROSCI.4297-06.2006
   Reyes BAS, 2005, EUR J NEUROSCI, V22, P93, DOI 10.1111/j.1460-9568.2005.04197.x
   Reyes BAS, 2008, ENDOCRINOLOGY, V149, P122, DOI 10.1210/en.2007-0705
   del Paso GAR, 2013, PSYCHOPHYSIOLOGY, V50, P477, DOI 10.1111/psyp.12027
   Rotenberg S, 2014, PSYCHONEUROENDOCRINO, V40, P69, DOI 10.1016/j.psyneuen.2013.10.002
   Rotenberg S, 2012, PSYCHONEUROENDOCRINO, V37, P1981, DOI 10.1016/j.psyneuen.2012.04.014
   Sapolsky RM, 2000, ENDOCR REV, V21, P55, DOI 10.1210/er.21.1.55
   Sellers RM, 2006, J RES ADOLESCENCE, V16, P187, DOI 10.1111/j.1532-7795.2006.00128.x
   Sen Y, 2008, NEUROENDOCRINOL LETT, V29, P141
   SGOUTASEMCH SA, 1994, PSYCHOPHYSIOLOGY, V31, P264, DOI 10.1111/j.1469-8986.1994.tb02215.x
   Shahar T, 2007, STRESS, V10, P145, DOI 10.1080/10253890701424712
   Shonkoff JP, 2009, JAMA-J AM MED ASSOC, V301, P2252, DOI 10.1001/jama.2009.754
   SLOAN RP, 1994, BIOL PSYCHOL, V37, P89, DOI 10.1016/0301-0511(94)90024-8
   Slopen N, 2013, PSYCHONEUROENDOCRINO, V38, P188, DOI 10.1016/j.psyneuen.2012.05.013
   Stalder T, 2011, PSYCHONEUROENDOCRINO, V36, P454, DOI [10.1016/j.psyneuen.2010.07.020, 10.1016/j.psyneuen.2010.02.014]
   Sztajzel J, 2004, SWISS MED WKLY, V134, P514
   Thayer JF, 2000, J AFFECT DISORDERS, V61, P201, DOI 10.1016/S0165-0327(00)00338-4
   Thayer JF, 2006, ANN NY ACAD SCI, V1088, P361, DOI 10.1196/annals.1366.014
   UCHINO BN, 1995, J PERS SOC PSYCHOL, V69, P736, DOI 10.1037/0022-3514.69.4.736
   Ulrich-Lai YM, 2006, AM J PHYSIOL-REG I, V290, pR1128, DOI 10.1152/ajpregu.00042.2003
   Ulrich-Lai YM, 2009, NAT REV NEUROSCI, V10, P397, DOI 10.1038/nrn2647
   Valentino RJ, 2008, EUR J PHARMACOL, V583, P194, DOI 10.1016/j.ejphar.2007.11.062
   Van den Bergh BRH, 2009, PSYCHONEUROENDOCRINO, V34, P791, DOI 10.1016/j.psyneuen.2008.12.008
   Weber CS, 2010, EUR J APPL PHYSIOL, V109, P201, DOI 10.1007/s00421-009-1341-x
   Williamson DE, 2005, J CHILD ADOL PSYCHOP, V15, P571, DOI 10.1089/cap.2005.15.571
   Ziegler DR, 1999, J NEUROENDOCRINOL, V11, P361
NR 97
TC 90
Z9 116
U1 0
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0301-0511
EI 1873-6246
J9 BIOL PSYCHOL
JI Biol. Psychol.
PD MAY
PY 2016
VL 117
BP 16
EP 25
DI 10.1016/j.biopsycho.2016.01.015
PG 10
WC Psychology, Biological; Behavioral Sciences; Psychology; Psychology,
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA DL5CE
UT WOS:000375654000003
PM 26835595
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Olgar, Y
   Turan, B
AF Olgar, Yusuf
   Turan, Belma
TI A sodium-glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin
   comparison with insulin shows important effects on
   Zn<SUP>2+</SUP>-transporters in cardiomyocytes from insulin-resistant
   metabolic syndrome rats through inhibition of oxidative stress
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article; Proceedings Paper
CT 6th Annual Meeting of the North-American-Section of the
   International-Academy-of-Cardiovascular-Sciences (Cardiology)
CY JUN 05-08, 2018
CL Havana, CUBA
SP Int Acad Cardiovascular Sci, N Amer Sect
DE diabetes; SGLT2 inhibitors; heart function; oxidative stress; matrix
   metalloproteins; heart
ID MATRIX METALLOPROTEINASES; EMPAGLIFLOZIN IMPROVES; EXPRESSION LEVELS;
   RETICULUM STRESS; HEART; DYSFUNCTION; OBESITY; HOMEOSTASIS; INDUCTION;
   INCREASE
AB Sodium-glucose cotransporter 2 (SGLT2) inhibitors showed significant effects in patients with diabetes or metabolic syndrome (MetS) with high cardiovascular risk. Although the increased intracellular Zn2+ level ([Zn2+](i)), oxidative stress, and altered cardiac matrix metalloproteinases (MMPs) in diabetic cardiomyopathy can intersect with different signaling pathways, the exact mechanisms are not known yet. Since either MMPs or SGLT2 have important roles in cardiac-fibrosis under hyperglycemia, we aimed to examine the role of SGLT2 inhibitor dapagliflozin (DAP) on cardiac Zn2+-transporters responsible for [Zn2+](i)-regulation, comparison to insulin (INS), together with MMP levels and systemic oxidative stress status in MetS-rats. High-carbohydrated diet-induced MetS-rats received DAP or INS for 2 weeks. DAP but not INS in MetS-rats significantly decreased high blood-glucose levels, while both treatments exerted benefits on increased total oxidative status and decreased total antioxidant status in MetS-rat plasma as well as in heart tissue. Protein levels of Zn2+-transporters, responsible for Zn2+-influx into cytosol, ZIP7 and ZIP14 were increased with significant decrease in ZIP8 of MetS-rat cardiomyoctes, while Zn2+-transporters, responsible for cytosolic Zn2+-efflux, ZnT7 was decreased with no change in ZnT8. Both treatments induced significant beneficial effects on altered ZIP14, ZIP8, and ZnT7 levels. Furthermore, both treatments exerted benefits on depressed gelatin-zymography and protein expression levels of MMP-2 and MMP-9 in MetS-rat ventricular cardiomyocytes. The direct effect of DAP on heart was also confirmed with measurements of left ventricular developed pressure. Overall, we showed that DAP has important antioxidant-like cardio-protective effects in MetS-rats, similar to INS-effect, affecting Zn2+-regulation via Zn2+-transporters, MMPs, and oxidative stress. Therefore one can suggest that SGLT2 inhibitors can be new therapeutic agents for cardio-protection not only in hyperglycemia but also in failing heart.
C1 [Olgar, Yusuf; Turan, Belma] Ankara Univ, Fac Med, Dept Biophys, Ankara, Turkey.
   [Olgar, Yusuf; Turan, Belma] Ankara Univ, Fac Med, Dept Internal Med, Ankara, Turkey.
C3 Ankara University; Ankara University
RP Turan, B (corresponding author), Ankara Univ, Fac Med, Dept Biophys, Ankara, Turkey.; Turan, B (corresponding author), Ankara Univ, Fac Med, Dept Internal Med, Ankara, Turkey.
EM belma.turan@medicine.ankara.edu.tr
RI olğar, yusuf/I-8960-2016; TURAN, Belma/AAG-8084-2020
OI TURAN, Belma/0000-0003-2583-9294; OLGAR, YUSUF/0000-0002-3226-7450
FU TUBITAK [SBAG-214S254]
FX The authors thank Erkan Tuncay and Sinan Degirmenci for their technical
   contribution to the study and Aysegul Durak for her help in caring for
   the experimental animals. This study was supported by TUBITAK
   SBAG-214S254 to BT.
CR Aguilar D, 2010, AM J CARDIOL, V105, P373, DOI 10.1016/j.amjcard.2009.09.041
   Ahmadieh H, 2017, DIABET METAB SYND OB, V10, P161, DOI 10.2147/DMSO.S122767
   Ayaz M, 2006, AM J PHYSIOL-HEART C, V290, pH1071, DOI 10.1152/ajpheart.00754.2005
   Baartscheer A, 2017, DIABETOLOGIA, V60, P568, DOI 10.1007/s00125-016-4134-x
   Berg G, 2014, HORM MOL BIOL CLIN I, V17, P79, DOI 10.1515/hmbci-2013-0069
   Bonomini F, 2015, AGING DIS, V6, P109, DOI 10.14336/AD.2014.0305
   Cameron AJ, 2012, INT J OBESITY, V36, P295, DOI 10.1038/ijo.2011.103
   Durak A, 2017, CAN J PHYSIOL PHARM, V95, P1335, DOI 10.1139/cjpp-2017-0054
   Erel O, 2004, CLIN BIOCHEM, V37, P112, DOI 10.1016/j.clinbiochem.2003.10.014
   Genser L, 2016, SURG CLIN N AM, V96, P681, DOI 10.1016/j.suc.2016.03.013
   Hammoudi N, 2017, CARDIOVASC DRUG THER, V31, P233, DOI 10.1007/s10557-017-6734-1
   Han SP, 2008, DIABETES, V57, P1723, DOI 10.2337/db07-1472
   Hansen HH, 2014, J PHARMACOL EXP THER, V350, P657, DOI 10.1124/jpet.114.213454
   Hopps E, 2012, EUR J INTERN MED, V23, P99, DOI 10.1016/j.ejim.2011.09.012
   Ilkun O, 2013, CURR PHARM DESIGN, V19, P4806, DOI 10.2174/1381612811319270003
   Jacobsen JA, 2010, BBA-MOL CELL RES, V1803, P72, DOI 10.1016/j.bbamcr.2009.08.006
   Kadoglou NPE, 2010, DIABETES METAB, V36, P144, DOI 10.1016/j.diabet.2009.11.004
   Kashiwagi A, 2017, J DIABETES INVEST, V8, P416, DOI 10.1111/jdi.12644
   Kramer CK, 2016, EUR HEART J, V37, P3201, DOI 10.1093/eurheartj/ehw158
   Kusaka H, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-016-0473-7
   Lahnwong S, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0745-5
   LAUER MS, 1992, J AM COLL CARDIOL, V19, P130, DOI 10.1016/0735-1097(92)90063-S
   Lee DM, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0708-x
   Liu BC, 2005, CHINESE MED J-PEKING, V118, P1040
   Mahjoub S, 2012, CASP J INTERN MED, V3, P386
   Moreira GC, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0105056
   Okatan EN, 2015, CAN J PHYSIOL PHARM, V93, P517, DOI 10.1139/cjpp-2014-0507
   Oku A, 1999, DIABETES, V48, P1794, DOI 10.2337/diabetes.48.9.1794
   Olgar Y, 2018, J CELL MOL MED, V22, P1944, DOI 10.1111/jcmm.13480
   Olgar Y, 2018, MOL CELL BIOCHEM, V440, P209, DOI 10.1007/s11010-017-3168-9
   Osorio H, 2012, OXID MED CELL LONGEV, V2012, DOI 10.1155/2012/542042
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sato T, 2017, DIABETIC MED, V34, P1367, DOI 10.1111/dme.13424
   Sawicki G, 1998, THROMB HAEMOSTASIS, V80, P836
   Shapiro SD, 1998, CURR OPIN CELL BIOL, V10, P602, DOI 10.1016/S0955-0674(98)80035-5
   Steven S, 2017, REDOX BIOL, V13, P370, DOI 10.1016/j.redox.2017.06.009
   Tahara A, 2013, EUR J PHARMACOL, V715, P246, DOI 10.1016/j.ejphar.2013.05.014
   Tanaka A, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-017-0532-8
   Tuncay E, 2019, MITOCHONDRION, V44, P41, DOI 10.1016/j.mito.2017.12.011
   Tuncay E, 2017, DIABETES, V66, P1346, DOI 10.2337/db16-1099
   Tuncay E, 2016, BIOL TRACE ELEM RES, V169, P294, DOI 10.1007/s12011-015-0423-3
   Tuncay E, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071014
   Tuncay E, 2011, CARDIOVASC RES, V89, P634, DOI 10.1093/cvr/cvq352
   Turan B, 1997, AM J PHYSIOL-HEART C, V272, pH2095, DOI 10.1152/ajpheart.1997.272.5.H2095
   VALLEE BL, 1993, PHYSIOL REV, V73, P79, DOI 10.2466/pr0.1993.73.1.79
   Yaras N, 2008, BRIT J PHARMACOL, V155, P1174, DOI 10.1038/bjp.2008.373
   Zinman B, 2015, NEW ENGL J MED, V373, P2117, DOI 10.1056/NEJMoa1504720
NR 47
TC 27
Z9 28
U1 0
U2 16
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD JUN
PY 2019
VL 97
IS 6
BP 528
EP 535
DI 10.1139/cjpp-2018-0466
PG 8
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Pharmacology & Pharmacy; Physiology
GA HZ9YH
UT WOS:000469213300011
PM 30444646
DA 2025-06-11
ER

PT J
AU Gliozzi, M
   Macri, R
   Coppoletta, AR
   Musolino, V
   Carresi, C
   Scicchitano, M
   Bosco, F
   Guarnieri, L
   Cardamone, A
   Ruga, S
   Scarano, F
   Nucera, S
   Mollace, R
   Bava, I
   Caminiti, R
   Serra, M
   Maiuolo, J
   Palma, E
   Mollace, V
AF Gliozzi, Micaela
   Macri, Roberta
   Coppoletta, Anna Rita
   Musolino, Vincenzo
   Carresi, Cristina
   Scicchitano, Miriam
   Bosco, Francesca
   Guarnieri, Lorenza
   Cardamone, Antonio
   Ruga, Stefano
   Scarano, Federica
   Nucera, Saverio
   Mollace, Rocco
   Bava, Irene
   Caminiti, Rosamaria
   Serra, Maria
   Maiuolo, Jessica
   Palma, Ernesto
   Mollace, Vincenzo
TI From Diabetes Care to Heart Failure Management: A Potential Therapeutic
   Approach Combining SGLT2 Inhibitors and Plant Extracts
SO NUTRIENTS
LA English
DT Review
DE diabetes; insulin resistance; lipid accumulation; inflammation; reactive
   oxygen species (ROS); SGLT2 inhibitors; nutraceutical supplementation;
   cardiovascular risk
ID INSULIN-RESISTANCE; ANTIOXIDANT STATUS; BERBERIS-VULGARIS; OXIDATIVE
   STRESS; M2 MACROPHAGES; PPAR-GAMMA; RATS; INFLAMMATION; MELLITUS;
   METAANALYSIS
AB Diabetes is a complex chronic disease, and among the affected patients, cardiovascular disease (CVD)is the most common cause of death. Consequently, the evidence for the cardiovascular benefit of glycaemic control may reduce long-term CVD rates. Over the years, multiple pharmacological approaches aimed at controlling blood glucose levels were unable to significantly reduce diabetes-related cardiovascular events. In this view, a therapeutic strategy combining SGLT2 inhibitors and plant extracts might represent a promising solution. Indeed, countering the main cardiometabolic risk factor using plant extracts could potentiate the cardioprotective action of SGLT2 inhibitors. This review highlights the main molecular mechanisms underlying these beneficial effects that could contribute to the better management of diabetic patients.
C1 [Gliozzi, Micaela; Macri, Roberta; Coppoletta, Anna Rita; Scicchitano, Miriam; Bosco, Francesca; Guarnieri, Lorenza; Cardamone, Antonio; Ruga, Stefano; Scarano, Federica; Nucera, Saverio; Mollace, Rocco; Bava, Irene; Caminiti, Rosamaria; Serra, Maria; Mollace, Vincenzo] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Pharmacol Lab, Inst Res Food Safety & Hlth IRC FSH, I-88100 Catanzaro, Italy.
   [Musolino, Vincenzo; Maiuolo, Jessica] Magna Graecia Univ Catanzaro, Inst Res Food Safety & Hlth IRC FSH, Dept Hlth Sci, Pharmaceut Biol Lab, I-88100 Catanzaro, Italy.
   [Carresi, Cristina; Palma, Ernesto] Magna Graecia Univ Catanzaro, Inst Res Food Safety & Hlth IRC FSH, Dept Hlth Sci, Vet Pharmacol Lab, I-88100 Catanzaro, Italy.
   [Mollace, Vincenzo] Renato Dulbecco Inst, I-88046 Catanzaro, Italy.
C3 Magna Graecia University of Catanzaro; Magna Graecia University of
   Catanzaro; Magna Graecia University of Catanzaro
RP Musolino, V (corresponding author), Magna Graecia Univ Catanzaro, Inst Res Food Safety & Hlth IRC FSH, Dept Hlth Sci, Pharmaceut Biol Lab, I-88100 Catanzaro, Italy.; Carresi, C (corresponding author), Magna Graecia Univ Catanzaro, Inst Res Food Safety & Hlth IRC FSH, Dept Hlth Sci, Vet Pharmacol Lab, I-88100 Catanzaro, Italy.
EM v.musolino@unicz.it; carresi@unicz.it
RI Musolino, Vincenzo/AAC-6429-2022; MACRI', Roberta/AAC-5967-2022;
   Coppoletta, Annarita/LSK-7367-2024; Gliozzi, Micaela/D-4405-2015; serra,
   maria/LSJ-0107-2024; SCARANO, FEDERICA/HNC-2414-2023; Cardamone,
   Antonio/HGA-5612-2022; carresi, cristina/AAC-6354-2022; Mollace,
   Rocco/ABH-5643-2020; nucera, saverio/AAC-6570-2022; Maiuolo,
   Jessica/AAU-2482-2020; Ruga, Stefano/JUV-6384-2023; Palma,
   ERNESTO/KRP-9299-2024
OI Mollace, Rocco/0000-0002-7106-5595; mollace,
   vincenzo/0000-0002-0392-7173; Guarnieri, Lorenza/0009-0007-5865-8779;
   Bosco, Francesca/0009-0004-4766-9710; Ruga, Stefano/0009-0008-0401-4027;
   SCARANO, FEDERICA/0000-0002-9838-9469; Musolino,
   Vincenzo/0000-0002-4763-2211; carresi, cristina/0000-0002-3509-5930;
   PALMA, Ernesto/0000-0003-4199-207X; serra, maria/0009-0005-7736-2207;
   Coppoletta, Anna Rita/0009-0000-5576-1139; MACRI',
   Roberta/0000-0002-2345-6751; Cardamone, Antonio/0000-0002-9091-1806
FU Italian Ministry of Research; POR Calabria FESR 2014-2020-PON-MIUR
   [03PE000_78_1]; PONMIUR [03PE000_78_2]; PRIR Calabria Asse 1/Azione
   1.5.1/FESR (Progetto AgrInfra Calabria)
FX The work was supported by public resources from the Italian Ministry of
   Research and POR Calabria FESR 2014-2020-PON-MIUR 03PE000_78_1 and
   PONMIUR 03PE000_78_2. PRIR Calabria Asse 1/Azione 1.5.1/FESR (Progetto
   AgrInfra Calabria).
CR Amer Diabet Assoc, 2021, DIABETES CARE, V44, pS73, DOI 10.2337/dc21-S006
   Amer Diabet Assoc Professional Pra, 2022, DIABETES CARE, V45, pS17, DOI 10.2337/dc22-S002
   Arayne MS, 2007, PAK J PHARM SCI, V20, P83
   Aroor AR, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0750-8
   Aubert G, 2016, CIRCULATION, V133, P698, DOI 10.1161/CIRCULATIONAHA.115.017355
   Baartscheer A, 2017, DIABETOLOGIA, V60, P568, DOI 10.1007/s00125-016-4134-x
   Bajpai A, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01547
   Bedi KC, 2016, CIRCULATION, V133, P706, DOI 10.1161/CIRCULATIONAHA.115.017545
   Booij HG, 2017, EXPERT REV MOL DIAGN, V17, P141, DOI 10.1080/14737159.2017.1266939
   Burhans MS, 2019, COMPR PHYSIOL, V9, P1, DOI 10.1002/cphy.c170040
   Cai XL, 2018, OBESITY, V26, P70, DOI 10.1002/oby.22066
   Carresi C, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010275
   Carresi C, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051504
   CEMERIKIC D, 1982, J MEMBRANE BIOL, V69, P159, DOI 10.1007/BF01872275
   Chen S, 2022, CARDIOVASC DIABETOL, V21, DOI 10.1186/s12933-022-01480-1
   Cherney DZI, 2018, KIDNEY INT, V93, P231, DOI 10.1016/j.kint.2017.06.017
   Cherney DZI, 2014, CARDIOVASC DIABETOL, V13, DOI 10.1186/1475-2840-13-28
   Chinetti G, 2001, NAT MED, V7, P53, DOI 10.1038/83348
   Cho H, 2001, J BIOL CHEM, V276, P38349, DOI 10.1074/jbc.C100462200
   Cinti F, 2017, DRUG DES DEV THER, V11, P2905, DOI 10.2147/DDDT.S114932
   Clamp LD, 2017, NUTR DIABETES, V7, DOI 10.1038/nutd.2017.31
   Cook JR, 2015, J BIOL CHEM, V290, P13972, DOI 10.1074/jbc.M115.638197
   Cristóbal-Garcia M, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/535686
   Heras ND, 2017, APPL PHYSIOL NUTR ME, V42, P209, DOI 10.1139/apnm-2016-0374
   Dong XC, 2008, CELL METAB, V8, P65, DOI 10.1016/j.cmet.2008.06.006
   Escudero DS, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.617519
   Gardana C, 2008, MOLECULES, V13, P2220, DOI 10.3390/molecules13092220
   Gisler SM, 2003, KIDNEY INT, V64, P1746, DOI 10.1046/j.1523-1755.2003.00267.x
   Gliozzi M., 2014, Advances in Biological Chemistry, V4, P129, DOI 10.4236/abc.2014.42017
   Gomaa AA, 2019, BIOMED PHARMACOTHER, V109, P281, DOI 10.1016/j.biopha.2018.10.056
   Goncalves C, 2022, MOLECULES, V27, DOI 10.3390/molecules27030609
   Govindaraj J, 2015, MOL CELL BIOCHEM, V404, P143, DOI 10.1007/s11010-015-2374-6
   Grundy SM, 2005, AM J CARDIOL, V95, P462, DOI 10.1016/j.amjcard.2004.10.012
   Habibi J, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-016-0489-z
   Hammoudi N, 2017, CARDIOVASC DRUG THER, V31, P233, DOI 10.1007/s10557-017-6734-1
   Hayashi T, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-016-0491-5
   He L, 2020, BIOCHEM J, V477, P1021, DOI 10.1042/BCJ20190570
   Hoong CWS, 2021, ENDOCRINOLOGY, V162, DOI 10.1210/endocr/bqab079
   Imenshahidi M, 2014, JUNDISHAPUR J NAT PH, V9, DOI 10.17795/jjnpp-16145
   Ji WJ, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0179960
   Jiang Y, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.802992
   Kamijo Y, 2019, CLIN MED INSIGHTS-EN, V12, DOI 10.1177/1179551419866811
   Kim SR, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-15983-6
   Koike Y, 2019, DIABETES RES CLIN PR, V149, P140, DOI 10.1016/j.diabres.2019.01.029
   Kozics K, 2013, FOOD CHEM, V141, P2198, DOI 10.1016/j.foodchem.2013.04.089
   Larkin HD, 2022, JAMA-J AM MED ASSOC, V327, P1219, DOI [10.1001/jama.2022.4556, 10.1001/jama.2022.3970]
   Layton AT, 2016, AM J PHYSIOL-RENAL, V310, pF1269, DOI 10.1152/ajprenal.00543.2015
   Lee H, 2016, J ETHNOPHARMACOL, V178, P229, DOI 10.1016/j.jep.2015.12.017
   Lee J, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10010081
   Levey AS, 2009, ANN INTERN MED, V150, P604, DOI 10.7326/0003-4819-150-9-200905050-00006
   Li CG, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0816-2
   Li CY, 2018, MED SCI MONIT BASIC, V24, P1, DOI 10.12659/MSMBR.907775
   Li LR, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.589273
   Lin JY, 2019, MED SCI MONITOR, V25, P87, DOI 10.12659/MSM.911849
   Lipkowitz MS, 2012, CURR RHEUMATOL REP, V14, DOI 10.1007/s11926-012-0240-z
   Mahmoud MF, 2017, PHARM BIOL, V55, P758, DOI 10.1080/13880209.2016.1275026
   Mollace V, 2008, J CARDIOVASC PHARM T, V13, P120, DOI 10.1177/1074248407313821
   Mollace V, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010257
   Mollace V, 2011, FITOTERAPIA, V82, P309, DOI 10.1016/j.fitote.2010.10.014
   Mone P, 2023, J PHARMACOL EXP THER, V384, P116, DOI 10.1124/jpet.121.001251
   Mone P, 2022, HYPERTENSION, V79, P1633, DOI 10.1161/HYPERTENSIONAHA.122.19586
   Mousum SA, 2018, INFLAMMOPHARMACOLOGY, V26, P1415, DOI 10.1007/s10787-018-0497-6
   Musolino V, 2020, J TRADIT COMPL MED, V10, P268, DOI 10.1016/j.jtcme.2020.02.004
   Musolino V, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-59485-3
   Nakae J, 2001, J CLIN INVEST, V108, P1359, DOI 10.1172/JCI200112876
   Ngueguim FT, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1009-0
   Okamoto A, 2016, DRUGS R&D, V16, P255, DOI 10.1007/s40268-016-0137-9
   Onishi A, 2020, AM J PHYSIOL-RENAL, V319, pF712, DOI 10.1152/ajprenal.00264.2020
   Packer M, 2017, CIRCULATION, V136, P1548, DOI 10.1161/CIRCULATIONAHA.117.030418
   Palmer SC, 2021, BMJ-BRIT MED J, V372, DOI 10.1136/bmj.m4573
   Paolisso P, 2022, CARDIOVASC DIABETOL, V21, DOI 10.1186/s12933-022-01506-8
   Park SH, 2021, CARDIOVASC DIABETOL, V20, DOI 10.1186/s12933-021-01252-3
   Pellegrini C, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20122876
   Prattichizzo F, 2021, METABOLISM, V120, DOI 10.1016/j.metabol.2021.154799
   Rahman A, 2017, CLIN EXP PHARMACOL P, V44, P522, DOI 10.1111/1440-1681.12725
   Reid J B, 1990, Radiol Technol, V61, P307
   Salerno Raffaele, 2016, PharmaNutrition, V4, pS1, DOI 10.1016/j.phanu.2015.10.001
   Sano M, 2020, THER ADV CARDIO DIS, V14, DOI 10.1177/1753944720939383
   Sasaki T, 2019, J DIABETES INVEST, V10, P108, DOI 10.1111/jdi.12851
   Schmoll D, 2000, J BIOL CHEM, V275, P36324, DOI 10.1074/jbc.M003616200
   Seferovic PM, 2020, EUR J HEART FAIL, V22, P1495, DOI 10.1002/ejhf.1954
   Seferovic PM, 2019, EUR J HEART FAIL, V21, P1169, DOI 10.1002/ejhf.1531
   Sharma S, 2017, BIOMED PHARMACOTHER, V89, P447, DOI 10.1016/j.biopha.2017.02.048
   Shi FH, 2021, DIABETES OBES METAB, V23, P2125, DOI 10.1111/dom.14452
   Shim DW, 2016, J MED FOOD, V19, P310, DOI 10.1089/jmf.2015.3556
   Rossi JLS, 2022, DIABETES-METAB RES, V38, DOI 10.1002/dmrr.3502
   Singh AK, 2019, DIABETES THER, V10, P393, DOI 10.1007/s13300-019-0562-1
   Sposito AC, 2021, CARDIOVASC DIABETOL, V20, DOI 10.1186/s12933-021-01264-z
   Sukhanov S, 2021, CELL SIGNAL, V77, DOI 10.1016/j.cellsig.2020.109825
   Szekeres Z, 2021, METABOLITES, V11, DOI 10.3390/metabo11020087
   Thiele K, 2022, ESC HEART FAIL, V9, P2233, DOI 10.1002/ehf2.13955
   Thorvaldsen T, 2022, J CARD FAIL, V28, P1050, DOI 10.1016/j.cardfail.2022.04.011
   Tomosaka H, 2008, PHYTOTHER RES, V22, P979, DOI 10.1002/ptr.2443
   Trum M, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22157976
   Valdivia CR, 2005, J MOL CELL CARDIOL, V38, P475, DOI 10.1016/j.yjmcc.2004.12.012
   Varzideh F, 2021, EUR HEART J-CARD PHA, V7, pE67, DOI 10.1093/ehjcvp/pvab039
   Vergès B, 2006, CURR OPIN LIPIDOL, V17, P653, DOI 10.1097/01.mol.0000252612.21602.e3
   Verma S, 2018, JACC-BASIC TRANSL SC, V3, P576
   Wei R, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.826604
   Wilcox CS, 2020, HYPERTENSION, V75, P894, DOI 10.1161/HYPERTENSIONAHA.119.11684
   Wilcox CS, 2018, J AM HEART ASSOC, V7, DOI 10.1161/JAHA.117.007046
   Xu J, 2022, J CLIN MED, V11, DOI 10.3390/jcm11010137
   Xu L, 2018, ADIPOCYTE, V7, P121, DOI 10.1080/21623945.2017.1413516
   Xu L, 2017, EBIOMEDICINE, V20, P137, DOI 10.1016/j.ebiom.2017.05.028
   Yurista SR, 2019, EUR J HEART FAIL, V21, P862, DOI 10.1002/ejhf.1473
   Zannad F, 2022, EUR HEART J, V43, P4991, DOI 10.1093/eurheartj/ehac495
   Zannad F, 2020, LANCET, V396, P819, DOI 10.1016/S0140-6736(20)31824-9
   Zhang CH, 2014, J ETHNOPHARMACOL, V151, P864, DOI 10.1016/j.jep.2013.11.054
   Zhang XZ, 2007, J PLANT PHYSIOL, V164, P574, DOI 10.1016/j.jplph.2006.03.011
   Zinman B, 2014, CARDIOVASC DIABETOL, V13, DOI 10.1186/1475-2840-13-102
NR 110
TC 10
Z9 10
U1 1
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2022
VL 14
IS 18
AR 3737
DI 10.3390/nu14183737
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 4U6VK
UT WOS:000858928900001
PM 36145112
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Haghighi, M
   Barikani, R
   Jahangard, L
   Ahmadpanah, M
   Bajoghli, H
   Bahmani, DS
   Holsboer-Trachsler, E
   Brand, S
AF Haghighi, Mohammad
   Barikani, Reza
   Jahangard, Leila
   Ahmadpanah, Mohammad
   Bajoghli, Hafez
   Bahmani, Dena Sadeghi
   Holsboer-Trachsler, Edith
   Brand, Serge
TI Levels of mania and cognitive performance two years after ECT in
   patients with bipolar I disorder - results from a follow-up study
SO COMPREHENSIVE PSYCHIATRY
LA English
DT Article
ID ELECTROCONVULSIVE-THERAPY; METABOLIC SYNDROME; SUICIDAL-BEHAVIOR; MAJOR
   DEPRESSION; SODIUM VALPROATE; HCL-32; ADOLESCENTS; IMPAIRMENT;
   CONSORTIUM; INVENTORY
AB Background: There is limited evidence on the long-term outcomes for patients with bipolar I disorder (BP-I-D) and treated with ECT. Therefore, we asked whether mania scores and cognitive performance at the end of ECT treatment (baseline/BL) predicted mania scores, cognitive performance, recurrence, treatment adherence, and mood (depression; hypomania) two years later (follow-up/FU).
   Method: 38 patients with BP-I-D undergoing ECT at baseline were followed up two years later. A brief psychiatric and cognitive assessment (Mini Mental State Examination; short-term verbal memory test) was performed; patients completed questionnaires covering recurrence, treatment adherence, and mood (depression; hypomania).
   Results: High cognitive performance at BL predicted high cognitive performance at FU; low mania scores at BL predicted low mania scores at FU. By FU, cognitive performance had increased and mania scores decreased. Mania scores and cognitive performance at BL did not predict recurrence, or adherence to medication, or mood (depression; hypomania).
   Conclusions: The pattern of results suggests that after two years of successful treatment of acute mania with ECT, cognitive impairment, measured by MMSE and a short-term verbal memory test, is not impaired and mood symptom recurrence seems to be improved. Mania scores and cognitive performance at the end of ECT treatment predicted neither mood (depression; hypomania), nor recurrence, or adherence to medication two years later. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Haghighi, Mohammad; Barikani, Reza; Jahangard, Leila; Ahmadpanah, Mohammad] Hamadan Univ Medial Sci, Res Ctr Behav Disorders & Subst Abuse, Hamadan, Iran.
   [Bajoghli, Hafez] Tehran Univ Medial Sci, Iranian Inst Reduct High Risk Behav, Iranian Natl Ctr Addict Studies INCAS, Tehran, Iran.
   [Bahmani, Dena Sadeghi; Holsboer-Trachsler, Edith; Brand, Serge] Univ Basel, Psychiat Clin, Ctr Affect Stress & Sleep Disorders, Wilhelm Klein Str 27, CH-4012 Basel, Switzerland.
   [Brand, Serge] Univ Basel, Dept Sport Exercise & Hlth, Basel, Switzerland.
C3 University of Basel; University of Basel; Swiss School of Public Health
   (SSPH+)
RP Brand, S (corresponding author), Univ Basel, Psychiat Clin, Ctr Affect Stress & Sleep Disorders, Wilhelm Klein Str 27, CH-4012 Basel, Switzerland.
EM serge.brand@upkbs.ch
RI Bahmani, Dena/H-8271-2019; Brand, Serge/H-7159-2019; ahmadpanah,
   mohammad/U-6860-2017; Jahangard, Leila/R-4159-2017; Haghighi,
   Mohammad/R-3453-2017
OI ahmadpanah, mohammad/0000-0003-2908-2460; Jahangard,
   Leila/0000-0002-2834-4644; Brand, Serge/0000-0003-2175-2765; Haghighi,
   Mohammad/0000-0002-4875-1036
CR Ahmadpanah M, 2015, INT J PSYCHIAT CLIN, V19, P168, DOI 10.3109/13651501.2015.1049277
   Angst J, 2005, J AFFECT DISORDERS, V88, P217, DOI 10.1016/j.jad.2005.05.011
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   Brand S, 2010, WORLD J BIOL PSYCHIA, V11, P594, DOI [10.3109/15622970903522501, 10.3109/15622970903521149]
   Busby KK, 2010, CNS NEUROSCI THER, V16, P308, DOI 10.1111/j.1755-5949.2010.00191.x
   Cohen D, 2000, AM J PSYCHIAT, V157, P460, DOI 10.1176/appi.ajp.157.3.460
   de la Serna E, 2011, J CHILD ADOL PSYCHOP, V21, P611, DOI 10.1089/cap.2011.0012
   Fink M, 2014, ACTA PSYCHIAT SCAND, V129, P417, DOI 10.1111/acps.12251
   FOLSTEIN MF, 1975, J PSYCHIAT RES, V12, P189, DOI 10.1016/0022-3956(75)90026-6
   Ghassemzadeh H, 2005, DEPRESS ANXIETY, V21, P185, DOI 10.1002/da.20070
   Ghaziuddin N, 2000, J CHILD ADOL PSYCHOP, V10, P269, DOI 10.1089/cap.2000.10.269
   Gonda X, 2012, J AFFECT DISORDERS, V143, P16, DOI 10.1016/j.jad.2012.04.041
   Haghighi M, 2013, NEUROPSYCHOBIOLOGY, V67, P14, DOI 10.1159/000343490
   Haghighi M, 2011, BMC PSYCHIATRY, V11, DOI 10.1186/1471-244X-11-14
   Holtmann M, 2009, J ADOLESCENCE, V32, P1075, DOI 10.1016/j.adolescence.2009.03.004
   Huuhka K, 2012, J ECT, V28, P225, DOI 10.1097/YCT.0b013e3182548f93
   Jahangard L, 2012, J ECT, V28, P118, DOI 10.1097/YCT.0b013e31824b64b5
   Kellner CH, 2006, ARCH GEN PSYCHIAT, V63, P1337, DOI 10.1001/archpsyc.63.12.1337
   MacQueen G, 2007, J PSYCHIATR NEUROSCI, V32, P241
   Medda P, 2013, J ECT, V29, P179, DOI 10.1097/YCT.0b013e3182887b7a
   Meeter M, 2011, J AFFECT DISORDERS, V132, P216, DOI 10.1016/j.jad.2011.02.026
   Merikangas KR, 2007, ARCH GEN PSYCHIAT, V64, P543, DOI 10.1001/archpsyc.64.5.543
   Meyer TD, 2007, COMPR PSYCHIAT, V48, P79, DOI 10.1016/j.comppsych.2006.07.001
   MONROE SM, 1991, PSYCHOL BULL, V110, P406, DOI 10.1037/0033-2909.110.3.406
   Neves FS, 2009, REV BRAS PSIQUIATR, V31, P114, DOI 10.1590/S1516-44462009000200006
   Rami L, 2008, PSYCHIAT RES, V158, P389, DOI 10.1016/j.psychres.2007.01.005
   Reisner AD, 2003, NEUROPSYCHOL REV, V13, P199, DOI 10.1023/B:NERV.0000009484.76564.58
   Russell JC, 2003, J ECT, V19, P4, DOI 10.1097/00124509-200303000-00002
   Shakeri J, 2015, INT J PSYCHIAT CLIN, V19, P124, DOI 10.3109/13651501.2014.988271
   Sienaert P, 2010, J AFFECT DISORDERS, V122, P60, DOI 10.1016/j.jad.2009.06.011
   Sienaert P, 2011, CAN J PSYCHIAT, V56, P5, DOI 10.1177/070674371105600103
   Thase Michael E, 2012, J Clin Psychiatry, V73, pe08, DOI 10.4088/JCP.10060tx3cc
   Versiani M, 2011, J ECT, V27, P153, DOI 10.1097/YCT.0b013e3181e6332e
   Warnell RL, 2011, ANN CLIN PSYCHIATRY, V23, P257
   Weiner RD., 2001, The Practice of Electroconvulsive Therapy: Recommendations for Treatment, Training and Privileging, V2nd Edn
   Woods DL, 2011, J CLIN EXP NEUROPSYC, V33, P101, DOI 10.1080/13803395.2010.493149
   YOUNG RC, 1978, BRIT J PSYCHIAT, V133, P429, DOI 10.1192/bjp.133.5.429
NR 37
TC 9
Z9 12
U1 0
U2 13
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0010-440X
EI 1532-8384
J9 COMPR PSYCHIAT
JI Compr. Psychiat.
PD AUG
PY 2016
VL 69
BP 71
EP 77
DI 10.1016/j.comppsych.2016.05.009
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DS1WS
UT WOS:000380416400009
PM 27423347
DA 2025-06-11
ER

PT J
AU Lakhani, HV
   Zehra, M
   Pillai, SS
   Puri, N
   Shapiro, JI
   Abraham, NG
   Sodhi, K
AF Lakhani, Hari Vishal
   Zehra, Mishghan
   Pillai, Sneha S.
   Puri, Nitin
   Shapiro, Joseph I.
   Abraham, Nader G.
   Sodhi, Komal
TI RETRACTED: Beneficial Role of HO-1-SIRT1 Axis in Attenuating Angiotensin
   II-Induced Adipocyte Dysfunction (Retracted article. See vol. 22, 2021)
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article; Retracted Publication
DE angiotensin II; mineralocorticoid receptor; heme oxygenase 1; sirtuin 1;
   adipocytes; oxidative stress
ID IMPROVES INSULIN SENSITIVITY; HEME OXYGENASE; ADIPOSE-TISSUE;
   MINERALOCORTICOID RECEPTOR; METABOLIC SYNDROME; VASCULAR DYSFUNCTION;
   OBESITY; ADIPONECTIN; ACTIVATION; DECREASE
AB Background: Angiotensin II (Ang II), released by the renin-angiotensin-aldosterone system (RAAS), contributes to the modulatory role of the RAAS in adipose tissue dysfunction. Investigators have shown that inhibition of AngII improved adipose tissue function and insulin resistance in mice with metabolic syndrome. Heme Oxygenase-1 (HO-1), a potent antioxidant, has been demonstrated to improve oxidative stress and adipocyte phenotype. Molecular effects of high oxidative stress include suppression of sirtuin-1 (SIRT1), which is amenable to redox manipulations. The mechanisms involved, however, in these metabolic effects of the RAAS remain incompletely understood. Hypothesis: We hypothesize that AngII-induced oxidative stress has the potential to suppress adipocyte SIRT1 via down regulation of HO-1. This effect of AngII will, in turn, upregulate mineralocorticoid receptor (MR). The induction of HO-1 will rescue SIRT1, hence improving oxidative stress and adipocyte phenotype. Methods and Results: We examined the effect of AngII on lipid accumulation, oxidative stress, and inflammatory cytokines in mouse pre-adipocytes in the presence and absence of cobalt protoporphyrin (CoPP), HO-1 inducer, tin mesoporphyrin (SnMP), and HO-1 inhibitor. Our results show that treatment of mouse pre-adipocytes with AngII increased lipid accumulation, superoxide levels, inflammatory cytokine levels, interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF alpha), and adiponectin levels. This effect was attenuated by HO-1 induction, which was further reversed by SnMP, suggesting HO-1 mediated improvement in adipocyte phenotype. AngII-treated pre-adipocytes also showed upregulated levels of MR and suppressed SIRT1 that was rescued by HO-1. Subsequent treatment with CoPP and SIRT1 siRNA in mouse pre-adipocytes increased lipid accumulation and fatty acid synthase (FAS) levels, suggesting that beneficial effects of HO-1 are mediated via SIRT1. Conclusion: Our study demonstrates for the first time that HO-1 has the ability to restore cellular redox, rescue SIRT1, and prevent AngII-induced impaired effects on adipocytes and the systemic metabolic profile.
C1 [Lakhani, Hari Vishal; Zehra, Mishghan; Pillai, Sneha S.; Puri, Nitin; Shapiro, Joseph I.; Sodhi, Komal] Marshall Univ, Joan C Edwards Sch Med, Dept Surg Internal Med & Biomed Sci, Huntington, WV 25701 USA.
   [Abraham, Nader G.] New York Med Coll, Dept Pharmacol, Valhalla, NY 10595 USA.
C3 Marshall University; New York Medical College
RP Sodhi, K (corresponding author), Marshall Univ, Joan C Edwards Sch Med, Dept Surg Internal Med & Biomed Sci, Huntington, WV 25701 USA.
EM sodhi@marshall.edu
FU National Institutes of Health [HL109015, HL105649, HL071556];
   Brickstreet Foundation
FX This work was supported by National Institutes of Health Grants to JIS
   (HL109015, HL105649 and HL071556), and by the Brickstreet Foundation
   (J.I.S.).
CR Abdul-Salam VB, 2010, ARTERIOSCL THROM VAS, V30, P1027, DOI 10.1161/ATVBAHA.109.199810
   Abraham NG, 2008, PHARMACOL REV, V60, P79, DOI 10.1124/pr.107.07104
   Abraham NG, 2016, TRENDS PHARMACOL SCI, V37, P17, DOI 10.1016/j.tips.2015.09.003
   Abraham NG, 2005, FREE RADICAL BIO MED, V39, P1, DOI 10.1016/j.freeradbiomed.2005.03.010
   Bartlett DE, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19092685
   Berg AH, 2005, CIRC RES, V96, P939, DOI 10.1161/01.RES.0000163635.62927.34
   Bordone L, 2005, NAT REV MOL CELL BIO, V6, P298, DOI 10.1038/nrm1616
   Boscaro M, 2012, ANN NY ACAD SCI, V1264, P87, DOI 10.1111/j.1749-6632.2012.06597.x
   Botros FT, 2005, KIDNEY INT, V68, P2745, DOI 10.1111/j.1523-1755.2005.00745.x
   Boustany CM, 2004, AM J PHYSIOL-REG I, V287, pR943, DOI 10.1152/ajpregu.00265.2004
   Briones AM, 2012, HYPERTENSION, V59, P1069, DOI 10.1161/HYPERTENSIONAHA.111.190223
   Burgess A, 2010, HYPERTENSION, V56, P1124, DOI 10.1161/HYPERTENSIONAHA.110.151423
   Cao J, 2012, HYPERTENSION, V60, P467, DOI 10.1161/HYPERTENSIONAHA.112.193805
   Chung SW, 2010, ARCH BIOCHEM BIOPHYS, V501, P79, DOI 10.1016/j.abb.2010.05.003
   Combs TP, 2004, ENDOCRINOLOGY, V145, P367, DOI 10.1210/en.2003-1068
   Duvnjak L, 2009, J PHYSIOL PHARMACOL, V60, P19
   FREDERICH RC, 1992, HYPERTENSION, V19, P339, DOI 10.1161/01.HYP.19.4.339
   Garrido AM, 2009, MOL CELL ENDOCRINOL, V302, P148, DOI 10.1016/j.mce.2008.11.003
   Gomez-Sanchez CE, 2015, HYPERTENSION, V66, P17, DOI 10.1161/HYPERTENSIONAHA.115.05148
   Gregoire FM, 1998, PHYSIOL REV, V78, P783, DOI 10.1152/physrev.1998.78.3.783
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Guberman C, 2013, AM J OBSTET GYNECOL, V209, DOI 10.1016/j.ajog.2013.05.023
   Hirata A, 2009, CARDIOVASC RES, V84, P164, DOI 10.1093/cvr/cvp191
   Karlsson C, 1998, J CLIN ENDOCR METAB, V83, P3925, DOI 10.1210/jc.83.11.3925
   Kim DH, 2008, J PHARMACOL EXP THER, V325, P833, DOI 10.1124/jpet.107.135285
   Kim DH, 2010, STEM CELLS DEV, V19, P1863, DOI 10.1089/scd.2010.0098
   Kim JY, 2007, J CLIN INVEST, V117, P2621, DOI 10.1172/JCI31021
   Kotronen A, 2008, ARTERIOSCL THROM VAS, V28, P27, DOI 10.1161/ATVBAHA.107.147538
   Kubota N, 2002, J BIOL CHEM, V277, P25863, DOI 10.1074/jbc.C200251200
   Li J, 2017, ONCOTARGET, V8, P65717, DOI 10.18632/oncotarget.20084
   Li M, 2008, DIABETES, V57, P1526, DOI 10.2337/db07-1764
   Li XL, 2013, ACTA BIOCH BIOPH SIN, V45, P51, DOI 10.1093/abbs/gms108
   Nagase M, 2009, HYPERTENS RES, V32, P649, DOI 10.1038/hr.2009.86
   Ndisang JF, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/359732
   Nguyen DinhCat A., 2013, Antioxid Redox Signal, V19, P1110, DOI DOI 10.1089/ars.2012.4641
   Nicolai A, 2009, HYPERTENSION, V53, P508, DOI 10.1161/HYPERTENSIONAHA.108.124701
   Paul M, 2006, PHYSIOL REV, V86, P747, DOI 10.1152/physrev.00036.2005
   Puri N, 2012, J CELL BIOCHEM, V113, P1926, DOI 10.1002/jcb.24061
   Singh SP, 2017, HORM MOL BIOL CLIN I, V31, DOI 10.1515/hmbci-2017-0027
   Singh SP, 2016, J NUTR METAB, V2016, DOI 10.1155/2016/9039754
   Sodhi K, 2014, INT J OBESITY, V38, P456, DOI 10.1038/ijo.2013.116
   Sodhi K, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0128648
   Sodhi K, 2012, PROSTAG OTH LIPID M, V98, P133, DOI 10.1016/j.prostaglandins.2011.12.004
   Togbo IDR, 2018, J Health Res, V5, P111, DOI [10.4103/jhrr.jhrr2718, DOI 10.4103/JHRR.JHRR2718]
   Vanella L, 2013, STEM CELL RES THER, V4, DOI 10.1186/scrt176
   Vanella L, 2012, INT J HYPERTENS, V2012, DOI 10.1155/2012/890671
   Vinatier D, 1995, EUR J OBSTET GYN R B, V63, P155, DOI 10.1016/0301-2115(95)02227-9
   Vogel J, 2003, NUCLEIC ACIDS RES, V31, P6435, DOI 10.1093/nar/gkg867
   Woo YC, 2013, CLIN ENDOCRINOL, V78, P489, DOI 10.1111/cen.12095
   Yvan-Charvet L, 2011, KIDNEY INT, V79, P162, DOI 10.1038/ki.2010.391
NR 50
TC 12
Z9 13
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL 1
PY 2019
VL 20
IS 13
AR 3205
DI 10.3390/ijms20133205
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA IL1EG
UT WOS:000477041100093
PM 31261892
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU De Oliveira, CM
   De Oliveira, C
   Scarabelot, VL
   Ströher, R
   Macedo, IC
   Souza, A
   Lopes, BC
   Caumo, W
   Torres, ILS
AF De Oliveira, Cleverson Moraes
   De Oliveira, Carla
   Scarabelot, Vanesssa Leal
   Stroher, Roberta
   Macedo, Isabel Cristina
   Souza, Andressa
   Lopes, Bettega Costa
   Caumo, Wolnei
   Silva Torres, Iraci Lucena
TI Hypercaloric diet and chronic stress desynchronizes the temporal pattern
   of rats' insulin release
SO BIOLOGICAL RHYTHM RESEARCH
LA English
DT Article
DE Circadian rhythms; metabolic disorders; high-fat foods; environmental
   factors; hormonal biomarkers
ID HIGH-FAT DIET; SUPRACHIASMATIC NUCLEUS CONTROLS; CLOCK MUTANT MICE;
   METABOLIC SYNDROME; CIRCADIAN-RHYTHMS; DIABETES-MELLITUS;
   FEEDING-BEHAVIOR; INDUCED OBESITY; ENERGY-BALANCE; BODY-WEIGHT
AB This study evaluated the effects of the association between obesity and chronic stress on the temporal pattern of serum levels of biochemical and hormonal markers. Obesity model was achieved by hypercaloric diet exposure. Wistar rats were divided into four groups: standard chow (C), hypercaloric diet (HD), stress + standard chow (S), and stress + hypercaloric diet (SHD) and analysed at three time points: ZTO, ZT12 and ZT18. Chronic stress was performed 1 h/per day, 5 days/per week, during 80 days. The presence of temporal pattern in naive animals' insulin release was accomplished. Hypercaloric diet induced obesity, increasing rats' insulin and glucose levels; while chronic stress reduced insulin levels. There were interactions between chronic stress and obesity in serum insulin and glucose levels; and between time points and obesity in insulin levels. In conclusion, long exposure to hypercaloric diet and chronic stress were able to desynchronize temporal pattern of insulin release, contributing to the pathophysiology of obesity and its complications.
C1 [De Oliveira, Cleverson Moraes; De Oliveira, Carla; Souza, Andressa; Caumo, Wolnei; Silva Torres, Iraci Lucena] Univ Fed Rio Grande do Sul, Programa Posgrad Ciencias Med, Porto Alegre, Brazil.
   [De Oliveira, Cleverson Moraes; De Oliveira, Carla; Scarabelot, Vanesssa Leal; Stroher, Roberta; Macedo, Isabel Cristina; Souza, Andressa; Lopes, Bettega Costa; Silva Torres, Iraci Lucena] Univ Fed Rio Grande do Sul, Dept Farmacol ICBS, Lab Farmacol Dor & Neuromodulacao Invest Preclin, Porto Alegre, RS, Brazil.
   [De Oliveira, Cleverson Moraes; De Oliveira, Carla; Scarabelot, Vanesssa Leal; Stroher, Roberta; Souza, Andressa; Lopes, Bettega Costa; Silva Torres, Iraci Lucena] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Unidade Expt Anim, Porto Alegre, RS, Brazil.
   [De Oliveira, Cleverson Moraes; De Oliveira, Carla; Scarabelot, Vanesssa Leal; Stroher, Roberta; Souza, Andressa; Lopes, Bettega Costa; Silva Torres, Iraci Lucena] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Grp Pesquisa & Posgrad, Porto Alegre, RS, Brazil.
   [Scarabelot, Vanesssa Leal] Univ Oeste Parana UNIOESTE, CCBS, Cascavel, Brazil.
   [Stroher, Roberta; Silva Torres, Iraci Lucena] Univ Fed Rio Grande do Sul, ICBS, Programa Posgrad Ciencias Biol Farmacol & Terapeu, Porto Alegre, RS, Brazil.
   [Macedo, Isabel Cristina] Univ Fed Pampa, Dept Ciencias Biol, Sao Gabriel, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Universidade Federal do Rio
   Grande do Sul; Hospital de Clinicas de Porto Alegre; Universidade
   Federal do Rio Grande do Sul; Universidade Federal do Rio Grande do Sul;
   Hospital de Clinicas de Porto Alegre; Universidade Estadual do Oeste do
   Parana; Universidade Federal do Rio Grande do Sul; Universidade Federal
   do Pampa
RP De Oliveira, C; Torres, ILS (corresponding author), Univ Fed Rio Grande do Sul, Programa Posgrad Ciencias Med, Porto Alegre, Brazil.; De Oliveira, C; Torres, ILS (corresponding author), Univ Fed Rio Grande do Sul, Dept Farmacol ICBS, Lab Farmacol Dor & Neuromodulacao Invest Preclin, Porto Alegre, RS, Brazil.; De Oliveira, C; Torres, ILS (corresponding author), Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Unidade Expt Anim, Porto Alegre, RS, Brazil.; De Oliveira, C; Torres, ILS (corresponding author), Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Grp Pesquisa & Posgrad, Porto Alegre, RS, Brazil.; Torres, ILS (corresponding author), Univ Fed Rio Grande do Sul, ICBS, Programa Posgrad Ciencias Biol Farmacol & Terapeu, Porto Alegre, RS, Brazil.
EM carla.doliveira@yahoo.com.br; iltorres@hcpa.edu.br
RI IC, Macedo/B-3151-2015; Costa Lopes, Bettega/AAG-5974-2020; Oliveira,
   Carla/F-6351-2015; caumo, wolnei/Q-8728-2016; de Souza,
   Andressa/Q-2446-2016; Oliveira, Cleverson/HPE-1938-2023; Torres, Iraci
   LS/G-6693-2012
OI Caumo, Wolnei/0000-0002-5083-4658; Costa Lopes,
   Bettega/0000-0002-8090-0273; Oliveira, Cleverson/0000-0003-0861-6136;
   Torres, Iraci LS/0000-0002-3081-115X
CR Arble DM, 2010, BEST PRACT RES CL EN, V24, P785, DOI 10.1016/j.beem.2010.08.003
   Atkinson HC, 2006, J NEUROENDOCRINOL, V18, P526, DOI 10.1111/j.1365-2826.2006.01444.x
   Bagnasco M, 2002, ENDOCRINOLOGY, V143, P726, DOI 10.1210/en.143.2.726
   Bartolomucci A, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004331
   Bass J, 2010, SCIENCE, V330, P1349, DOI 10.1126/science.1195027
   Bravo R, 2014, CHRONOBIOL INT, V31, P363, DOI 10.3109/07420528.2013.859151
   Bray GA, 2004, J CLIN ENDOCR METAB, V89, P2583, DOI 10.1210/jc.2004-0535
   Bray MS, 2007, OBES REV, V8, P169, DOI 10.1111/j.1467-789X.2006.00277.x
   Buse JB, 2007, CIRCULATION, V115, P114, DOI 10.1161/CIRCULATIONAHA.106.179294
   Cailotto C, 2005, EUR J NEUROSCI, V22, P2531, DOI 10.1111/j.1460-9568.2005.04439.x
   Coomans CP, 2013, DIABETES, V62, P1102, DOI 10.2337/db12-0507
   Davis S, 2006, CANCER CAUSE CONTROL, V17, P539, DOI 10.1007/s10552-005-9010-9
   de Oliveira C, 2015, STRESS, V18, P514, DOI 10.3109/10253890.2015.1079616
   de Oliveira C, 2014, PEPTIDES, V51, P46, DOI 10.1016/j.peptides.2013.10.024
   DeFronzo RA, 2009, DIABETES, V58, P773, DOI 10.2337/db09-9028
   Ely DR, 1997, PHYSIOL BEHAV, V61, P395, DOI 10.1016/S0031-9384(96)00450-7
   Estadella D, 2004, NUTRITION, V20, P218, DOI 10.1016/j.nut.2003.10.008
   Finger BC, 2012, PSYCHONEUROENDOCRINO, V37, P729, DOI 10.1016/j.psyneuen.2011.06.015
   Flak JN, 2011, PHYSIOL BEHAV, V104, P228, DOI 10.1016/j.physbeh.2011.03.002
   Flood JE, 2006, J AM DIET ASSOC, V106, P1984, DOI 10.1016/j.jada.2006.09.005
   Forbes JM, 2013, J NUTR BIOCHEM, V24, P1251, DOI 10.1016/j.jnutbio.2012.09.009
   Froy O, 2007, FRONT NEUROENDOCRIN, V28, P61, DOI 10.1016/j.yfrne.2007.03.001
   Gamble KL, 2014, NAT REV ENDOCRINOL, V10, P466, DOI 10.1038/nrendo.2014.78
   Garaulet M, 2009, CURR OPIN LIPIDOL, V20, P127, DOI 10.1097/MOL.0b013e3283292399
   Gomez-Abellan Purificacion, 2012, Endocrinol Nutr, V59, P50, DOI 10.1016/j.endonu.2011.08.002
   Gomez-Smith M, 2016, PHYSIOL BEHAV, V167, P382, DOI 10.1016/j.physbeh.2016.09.029
   Hastings M, 2007, J ENDOCRINOL, V195, P187, DOI 10.1677/JOE-07-0378
   Hruby A, 2015, PHARMACOECONOMICS, V33, P673, DOI 10.1007/s40273-014-0243-x
   Kalra SP, 2003, REGUL PEPTIDES, V111, P1, DOI 10.1016/S0167-0115(02)00305-1
   Kalsbeek A, 2014, MOL METAB, V3, P372, DOI 10.1016/j.molmet.2014.03.002
   Khalkhal A, 2012, CR BIOL, V335, P271, DOI 10.1016/j.crvi.2012.03.003
   Kohsaka A, 2007, CELL METAB, V6, P414, DOI 10.1016/j.cmet.2007.09.006
   Koolhaas JM, 2011, NEUROSCI BIOBEHAV R, V35, P1291, DOI 10.1016/j.neubiorev.2011.02.003
   Kudo T, 2007, J PHARMACOL SCI, V103, P139, DOI 10.1254/jphs.FMJ06003X3
   Kumar S, 2011, INDIAN J PHARMACOL, V43, P163, DOI 10.4103/0253-7613.77353
   la Fleur SE, 2001, DIABETES, V50, P1237, DOI 10.2337/diabetes.50.6.1237
   Ledikwe JH, 2005, J NUTR, V135, P273, DOI 10.1093/jn/135.2.273
   Macedo IC, 2012, PEPTIDES, V38, P189, DOI 10.1016/j.peptides.2012.08.007
   Nascimento AF, 2008, ARQ BRAS ENDOCRINOL, V52, P968, DOI 10.1590/S0004-27302008000600007
   O'Neil DS, 2017, AM J OBSTET GYNECOL, V217, DOI 10.1016/j.ajog.2017.03.024
   Oishi K, 2006, FEBS LETT, V580, P127, DOI 10.1016/j.febslet.2005.11.063
   Onat A, 2006, INT J CARDIOL, V108, P89, DOI 10.1016/j.ijcard.2005.06.056
   Ortolani D, 2011, PHYSIOL BEHAV, V103, P487, DOI 10.1016/j.physbeh.2011.03.028
   Phillips CM, 2013, NUTRIENTS, V5, P32, DOI 10.3390/nu5010032
   Piernas C, 2010, J NUTR, V140, P325, DOI 10.3945/jn.109.112763
   Portaluppi F, 2010, CHRONOBIOL INT, V27, P1911, DOI 10.3109/07420528.2010.516381
   Ramsey KM, 2007, ANNU REV NUTR, V27, P219, DOI 10.1146/annurev.nutr.27.061406.093546
   Reddy AB, 2010, TRENDS CELL BIOL, V20, P36, DOI 10.1016/j.tcb.2009.10.005
   Rudic RD, 2004, PLOS BIOL, V2, P1893, DOI 10.1371/journal.pbio.0020377
   Shi SQ, 2013, CURR BIOL, V23, P372, DOI 10.1016/j.cub.2013.01.048
   Solomon MB, 2007, AM J PHYSIOL-REG I, V292, pR283, DOI 10.1152/ajpregu.00330.2006
   Solomon MB, 2011, PHYSIOL BEHAV, V102, P84, DOI 10.1016/j.physbeh.2010.09.024
   Spiegelman BM, 2001, CELL, V104, P531, DOI 10.1016/S0092-8674(01)00240-9
   Stephens MAC, 2012, ALCOHOL RES-CURR REV, V34, P468
   Teegarden SL, 2008, PHYSIOL BEHAV, V93, P713, DOI 10.1016/j.physbeh.2007.11.030
   Thayer JF, 2010, INT J CARDIOL, V141, P122, DOI 10.1016/j.ijcard.2009.09.543
   Tolle V, 2002, ENDOCRINOLOGY, V143, P1353, DOI 10.1210/en.143.4.1353
   Torres SJ, 2007, NUTRITION, V23, P887, DOI 10.1016/j.nut.2007.08.008
   Turek FW, 2005, SCIENCE, V308, P1043, DOI 10.1126/science.1108750
   Ueno N, 2004, ENDOCRINOLOGY, V145, P4176, DOI 10.1210/en.2004-0262
NR 60
TC 0
Z9 0
U1 0
U2 0
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0929-1016
EI 1744-4179
J9 BIOL RHYTHM RES
JI Biol. Rhythm Res.
PY 2018
VL 49
IS 4
BP 643
EP 653
DI 10.1080/09291016.2017.1395528
PG 11
WC Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Physiology
GA GE0VG
UT WOS:000430934200012
DA 2025-06-11
ER

PT J
AU Rangel-Zuñiga, OA
   Haro, C
   Perez-Martinez, P
   Delgado-Lista, J
   Marin, C
   Quintana-Navarro, GM
   Tinahones, FJ
   Malagón, MM
   Lopez-Segura, F
   Lopez-Miranda, J
   Perez-Jimenez, F
   Camargo, A
AF Rangel-Zuniga, Oriol A.
   Haro, Carmen
   Perez-Martinez, Pablo
   Delgado-Lista, Javier
   Marin, Carmen
   Quintana-Navarro, Gracia M.
   Tinahones, Francisco J.
   Malagon, Maria M.
   Lopez-Segura, Fernando
   Lopez-Miranda, Jose
   Perez-Jimenez, Francisco
   Camargo, Antonio
TI Effect of frying oils on the postprandial endoplasmic reticulum stress
   in obese people
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE ER stress; Frying oil; Mononuclear cells; Phenolic compounds;
   Postprandial state
ID METABOLIC SYNDROME; OLIVE; ANTIOXIDANTS; CELLS
AB The addition of antioxidants to frying oil reduces postprandial oxidative stress and the inflammatory response. ER stress may trigger both inflammation and oxidative stress processes. We aimed to determine the biological effects of the intake of four models of frying oils on postprandial ER stress in peripheral blood mononuclear cells. Twenty obese people received four breakfasts following a randomized crossover design, consisting of muffins made with different oils (virgin olive oil (VOO), sunflower oil (SFO), and a mixture of seed oils (SFO/canola oil) with either dimethylpolysiloxane (SOD) or natural antioxidants from olives (SOP) added), which were previously subjected to 20 heating cycles. ER stress was assessed by measuring the mRNA levels of sXBP1, BiP, CRT, and CNX in peripheral blood mononuclear cells. Our study showed that the intake of the muffins made with SFO induced the postprandial increase of the mRNA levels of the ER stress-sensor sXBP1, and the ER stress related chaperones BiP and CRT (all p-values <0.05). The harmful effects associated with the use of SFO as frying oil, in terms of inflammatory response and postprandial oxidative stress, may be partially mediated by the induction of postprandial ER stress.
C1 [Rangel-Zuniga, Oriol A.; Haro, Carmen; Perez-Martinez, Pablo; Delgado-Lista, Javier; Marin, Carmen; Quintana-Navarro, Gracia M.; Lopez-Segura, Fernando; Lopez-Miranda, Jose; Perez-Jimenez, Francisco; Camargo, Antonio] Univ Cordoba, Lipids & Atherosclerosis Unit, IMIBIC, Reina Sofia Univ Hosp, E-14004 Cordoba, Spain.
   [Rangel-Zuniga, Oriol A.; Haro, Carmen; Perez-Martinez, Pablo; Delgado-Lista, Javier; Marin, Carmen; Quintana-Navarro, Gracia M.; Tinahones, Francisco J.; Malagon, Maria M.; Lopez-Segura, Fernando; Lopez-Miranda, Jose; Perez-Jimenez, Francisco; Camargo, Antonio] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBEROBN, Cordoba, Spain.
   [Tinahones, Francisco J.] Hosp Virgen Victoria, Endocrinol & Nutr Serv, Malaga, Spain.
   [Malagon, Maria M.] Univ Cordoba, Dept Cell Biol Physiol & Immunol, IMIBIC, Reina Sofia Univ Hosp, E-14004 Cordoba, Spain.
C3 Universidad de Cordoba; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN; Instituto de Salud Carlos III; Universidad de Cordoba
RP Camargo, A (corresponding author), Univ Cordoba, Lipids & Atherosclerosis Unit, IMIBIC, Reina Sofia Univ Hosp, Ave Menendez Pidal S-N, E-14004 Cordoba, Spain.
EM b92cagaa@uco.es
RI Lopez-Miranda, Jose/Y-8306-2019; Marin Hinojosa, Carmen/AFO-1294-2022;
   Tinahones, Francisco/AAB-2882-2020; Delgado-Lista, Javier/KAM-7412-2024;
   Jimenez, Francisco/AAJ-9559-2021; MALAGON, MARIA M/L-5386-2014; Camargo
   Garcia, Antonio/G-9720-2015; Perez Martinez, Pablo/AEL-6176-2022; HARO,
   CARMEN/P-3104-2016
OI MALAGON, MARIA M/0000-0002-2419-2727; Rangel-Zuniga, Oriol
   Alberto/0000-0003-3495-5705; QUINTANA-NAVARRO, GRACIA
   MARIA/0000-0003-4413-4062; Lopez-Miranda, Jose/0000-0002-8844-0718;
   Camargo Garcia, Antonio/0000-0002-0415-4184; Perez Jimenez,
   Francisco/0000-0001-9808-1280; Perez Martinez,
   Pablo/0000-0001-7716-8117; Delgado Lista, Francisco
   Javier/0000-0002-2982-2716; Tinahones, Francisco J/0000-0001-6871-4403;
   HARO, CARMEN/0000-0002-1355-8359; Perez-Jimenez,
   Francisco/0000-0001-7499-7681
FU Spanish Ministry of Science and Innovation [AGL 2004-07907, AGL
   2006-01979, AGL 2009-12270, SAF07-62005, FIS PI10/01041, PI10/02412];
   Consejeria de Economia, Innovacion y Ciencia, Proyectos de Investigacion
   de Excelencia, Junta de Andalucia [P06-CTS-01425, CTS5015, AGR922];
   Consejeria de Salud, Junta de Andalucia [06/128, 07/43, PI0193/09,
   06/129, 06/127, PI-0252/09, PI-0058/10]; Fondo Europeo de Desarrollo
   Regional (FEDER)
FX The CIBEROBN is an initiative of the Instituto de Salud Carlos III,
   Madrid, Spain. This study was supported in part by research grants from
   the Spanish Ministry of Science and Innovation (AGL 2004-07907, AGL
   2006-01979, and AGL 2009-12270 to J. L.-M., SAF07-62005 to F. P.-J., and
   FIS PI10/01041 to P. P.-M., PI10/02412 to F. P.-J.); Consejeria de
   Economia, Innovacion y Ciencia, Proyectos de Investigacion de
   Excelencia, Junta de Andalucia (P06-CTS-01425 to J. L.-M., CTS5015 and
   AGR922 to F. P.-J.); Consejeria de Salud, Junta de Andalucia (06/128,
   07/43, and PI0193/09 to J. L.-M, 06/129 to F. P.-J., 06/127 to C. M.-H.,
   PI-0252/09 to J. D.-L., and PI-0058/10 to P. P.-M.); Fondo Europeo de
   Desarrollo Regional (FEDER). We would also like to thank Jose Linares
   from DEOLEO, S.A., for providing the SFO used in this research, and the
   Catering School of Bodegas Campos in Cordoba, Spain, for cooperating in
   the standardized heating process of the four oils used in the present
   study.
CR Ansorena D, 2010, J FOOD SCI, V75, pH62, DOI 10.1111/j.1750-3841.2009.01472.x
   Biden TJ, 2014, TRENDS ENDOCRIN MET, V25, P389, DOI 10.1016/j.tem.2014.02.003
   Burczynski ME, 2006, PHARMACOGENOMICS, V7, P187, DOI 10.2217/14622416.7.2.187
   Camargo A, 2013, MOL NUTR FOOD RES, V57, P2166, DOI 10.1002/mnfr.201300036
   Casal S, 2010, FOOD CHEM TOXICOL, V48, P2972, DOI 10.1016/j.fct.2010.07.036
   Deng YF, 2013, J CLIN INVEST, V123, P455, DOI 10.1172/JCI62819
   Giordano E, 2014, MOL NUTR FOOD RES, V58, P954, DOI 10.1002/mnfr.201300465
   Gotoh T, 2011, INT J INFLAMM, V2011, DOI 10.4061/2011/259462
   Guichard C, 2006, CARCINOGENESIS, V27, P1812, DOI 10.1093/carcin/bgl009
   Haslam E, 1996, J NAT PROD, V59, P205, DOI 10.1021/np960040+
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   Mandl J, 2009, TRENDS ENDOCRIN MET, V20, P194, DOI 10.1016/j.tem.2009.01.003
   Marchetti P, 2007, DIABETOLOGIA, V50, P2486, DOI 10.1007/s00125-007-0816-8
   Oliván S, 2014, J NUTR BIOCHEM, V25, P885, DOI 10.1016/j.jnutbio.2014.04.005
   Perez-Herrera A, 2012, MOL NUTR FOOD RES, V56, P510, DOI 10.1002/mnfr.201100533
   Perez-Herrera A, 2013, FOOD CHEM, V138, P2250, DOI 10.1016/j.foodchem.2012.12.023
   Romero FJ, 1998, ENVIRON HEALTH PERSP, V106, P1229, DOI 10.2307/3433990
   Ron D, 2007, NAT REV MOL CELL BIO, V8, P519, DOI 10.1038/nrm2199
   Sage AT, 2012, OBESITY, V20, P748, DOI 10.1038/oby.2011.144
   van Oostrom AJHHM, 2004, ATHEROSCLEROSIS, V177, P175, DOI 10.1016/j.atherosclerosis.2004.07.004
   Velasco J, 2004, J AGR FOOD CHEM, V52, P4438, DOI 10.1021/jf030753f
NR 21
TC 10
Z9 11
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD NOV
PY 2014
VL 58
IS 11
BP 2239
EP 2242
DI 10.1002/mnfr.201400401
PG 4
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA AT8XK
UT WOS:000345212200015
PM 25164487
DA 2025-06-11
ER

PT J
AU Perez-Cornago, A
   Sanchez-Villegas, A
   Bes-Rastrollo, M
   Gea, A
   Molero, P
   Lahortiga-Ramos, F
   Martínez-González, MA
AF Perez-Cornago, Aurora
   Sanchez-Villegas, Almudena
   Bes-Rastrollo, Maira
   Gea, Alfredo
   Molero, Patricio
   Lahortiga-Ramos, Francisca
   Angel Martinez-Gonzalez, Miguel
TI Intake of High-Fat Yogurt, but Not of Low-Fat Yogurt or Prebiotics, Is
   Related to Lower Risk of Depression in Women of the SUN Cohort Study
SO JOURNAL OF NUTRITION
LA English
DT Article
DE depression; yogurt; prebiotics; fiber; probiotics
ID METABOLIC SYNDROME; SEGUIMIENTO-UNIVERSIDAD; DAIRY-PRODUCTS; GUT
   MICROBIOTA; BRAIN AXIS; PROBIOTICS; CONSUMPTION; HEALTH; DIET;
   ASSOCIATION
AB Background: Yogurt and prebiotic consumption has been linked to better health. However, to our knowledge, no longitudinal study has assessed the association of yogurt and prebiotic consumption with depression risk.
   Objective: We longitudinally evaluated the association of yogurt and prebiotic consumption with depression risk in a Mediterranean cohort.
   Methods: The SUN (Seguimiento Universidad de Navarra) Project is a dynamic, prospective cohort of Spanish university graduates. A total of 14,539 men and women (mean age: 37 y) initially free of depression were assessed during a median follow-up period of 9.3 y. Validated food-frequency questionnaires at baseline and after a 10-y follow-up were used to assess prebiotic (fructans and galacto-oligosaccharide) intake and yogurt consumption (<0.5, >= 0.5 to <3, >= 3 to <7, and >= 7 servings/wk). Participants were classified as incident cases of depression when they reported a new clinical diagnosis of depression by a physician (previously validated). Multivariable Cox proportional hazards models were used to calculate HRs and 95% Cls.
   Results: We identified 727 incident cases of depression during follow-up. Whole-fat yogurt intake was associated with reduced depression risk: HR for the highest [>= 7 servings/wk (1 serving = 125 g)] compared with the lowest (<0.5 servings/wk) consumption: 0.78 (95% CI: 0.63, 0.98; P-trend = 0.020). When stratified by sex, this association was significant only in women (HR: 0.66; 95% CI: 0.50, 0.87; P-trend = 0.004). Low-fat yogurt consumption was associated with a higher incidence of depression (HR: 1.32; 95% CI: 1.06, 1.65; P-trend = 0.001), although this association lost significance after the exclusion of early incident cases, suggesting possible reverse causation bias. Prebiotic consumption was not significantly associated with depression risk.
   Conclusions: Our study suggests that high consumption of whole-fat yogurt was related to a lower risk of depression in women of the SUN cohort. No association was observed for prebiotics. Further studies are needed to clarify why the yogurt-depression association may differ by fat content of the yogurt.
C1 [Perez-Cornago, Aurora; Bes-Rastrollo, Maira; Gea, Alfredo; Angel Martinez-Gonzalez, Miguel] Univ Navarra, Dept Prevent Med & Publ Hlth, Pamplona, Spain.
   [Perez-Cornago, Aurora] Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England.
   [Sanchez-Villegas, Almudena] Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci, Nutr Res Grp, Las Palmas Gran Canaria, Spain.
   [Sanchez-Villegas, Almudena; Bes-Rastrollo, Maira; Gea, Alfredo; Angel Martinez-Gonzalez, Miguel] Inst Hlth Carlos III, Biomed Res Ctr Network Obes & Nutr CIBERobn Physi, Madrid, Spain.
   [Bes-Rastrollo, Maira; Gea, Alfredo; Molero, Patricio; Lahortiga-Ramos, Francisca; Angel Martinez-Gonzalez, Miguel] Navarra Inst Hlth Res IdiSNA Pamplona, Pamplona, Spain.
   [Molero, Patricio; Lahortiga-Ramos, Francisca] Univ Navarra Clin, Dept Psychiat & Med Psychol, Pamplona, Spain.
C3 University of Navarra; University of Oxford; Universidad de Las Palmas
   de Gran Canaria; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEROBN; University of Navarra
RP Martínez-González, MA (corresponding author), Univ Navarra, Dept Prevent Med & Publ Hlth, Pamplona, Spain.; Martínez-González, MA (corresponding author), Inst Hlth Carlos III, Biomed Res Ctr Network Obes & Nutr CIBERobn Physi, Madrid, Spain.; Martínez-González, MA (corresponding author), Navarra Inst Hlth Res IdiSNA Pamplona, Pamplona, Spain.
EM mamartinez@unav.es
RI Sanchez-Villegas, Almudena/T-6733-2019; Martínez-González,
   Marina/R-6165-2016; Abad-Gurumeta, Alfredo/M-2337-2019;
   Martinez-Gonzalez, Miguel/AAE-7669-2019; Perez-Cornago,
   Aurora/C-1097-2016; BES-RASTROLLO, MAIRA/A-1329-2009; Molero,
   Patricio/K-8834-2013; Lahortiga-Ramos, Francisca/H-9363-2017
OI Perez-Cornago, Aurora/0000-0002-5652-356X; BES-RASTROLLO,
   MAIRA/0000-0002-9139-4206; Martinez-Gonzalez, Miguel
   A./0000-0002-3917-9808; Molero, Patricio/0000-0002-9287-9635;
   Lahortiga-Ramos, Francisca/0000-0001-7624-6902; Gea,
   Alfredo/0000-0002-2229-4690; Sanchez Villegas,
   Almudena/0000-0001-7733-9238
FU Spanish Government-Instituto de Salud Carlos III [PI01/0619, PI030678,
   PI040233, PI042241, PI050976, PI070240, PI070312, PI081943, PI080819,
   PI1002658, PI1002293, RD06/0045, 2010/087, G03/140]; Navarra Regional
   Government [36/2001, 43/2002, 41/2005, 36/2008, 45/2011]; Formacion de
   Profesorado Universitario FPU fellowship of the Ministerio de Educacion,
   Cultura y Deporte, Spanish Government
FX The SUN Project has received funding from the Spanish
   Government-Instituto de Salud Carlos III (grants PI01/0619, PI030678,
   PI040233, PI042241, PI050976, PI070240, PI070312, PI081943, PI080819,
   PI1002658, PI1002293, RD06/0045, 2010/087, and G03/140), the Navarra
   Regional Government (36/2001, 43/2002, 41/2005, 36/2008, and 45/2011),
   and the University of Navarra AG is supported by an Formacion de
   Profesorado Universitario FPU fellowship of the Ministerio de Educacion,
   Cultura y Deporte, Spanish Government.
CR Adolfsson O, 2004, AM J CLIN NUTR, V80, P245, DOI 10.1093/ajcn/80.2.245
   [Anonymous], CRIT REV FOOD SCI NU
   Babio N, 2015, J NUTR, V145, P2308, DOI 10.3945/jn.115.214593
   Bach A, 2006, PUBLIC HEALTH NUTR, V9, P132, DOI 10.1079/PHN2005936
   Belmaker RH, 2008, NEW ENGL J MED, V358, P55, DOI [10.1056/NEJMra073096, 10.1038/nrdp.2016.65]
   Borre YE, 2014, TRENDS MOL MED, V20, P509, DOI 10.1016/j.molmed.2014.05.002
   Dash S, 2015, CURR OPIN PSYCHIATR, V28, P1, DOI 10.1097/YCO.0000000000000117
   de la Fuente-Arrillaga C, 2010, PUBLIC HEALTH NUTR, V13, P1364, DOI 10.1017/S1368980009993065
   Desbonnet L, 2010, NEUROSCIENCE, V170, P1179, DOI 10.1016/j.neuroscience.2010.08.005
   Ejtahed HS, 2011, J DAIRY SCI, V94, P3288, DOI 10.3168/jds.2010-4128
   El-Abbadi NH, 2014, AM J CLIN NUTR, V99, p1263S, DOI 10.3945/ajcn.113.073957
   Elli M, 2006, APPL ENVIRON MICROB, V72, P5113, DOI 10.1128/AEM.02950-05
   Evrensel A, 2015, CLIN PSYCHOPHARM NEU, V13, P239, DOI 10.9758/cpn.2015.13.3.239
   Fernández-Ballarth JD, 2010, BRIT J NUTR, V103, P1808, DOI 10.1017/S0007114509993837
   Foster JA, 2013, TRENDS NEUROSCI, V36, P305, DOI 10.1016/j.tins.2013.01.005
   Gareau MG, 2007, GUT, V56, P1522, DOI 10.1136/gut.2006.117176
   Gibson GR, 2004, NUTR RES REV, V17, P259, DOI 10.1079/NRR200479
   Guarner F, 2005, BRIT J NUTR, V93, P783, DOI 10.1079/BJN20051428
   Hill C, 2014, NAT REV GASTRO HEPAT, V11, P506, DOI 10.1038/nrgastro.2014.66
   Jacka FN, 2010, AM J PSYCHIAT, V167, P305, DOI 10.1176/appi.ajp.2009.09060881
   Lai JS, 2014, AM J CLIN NUTR, V99, P181, DOI 10.3945/ajcn.113.069880
   Lin Chuan-Sheng, 2014, Biomed J, V37, P259, DOI 10.4103/2319-4170.138314
   Liu XF, 2015, J AGR FOOD CHEM, V63, P7885, DOI 10.1021/acs.jafc.5b02404
   Martinez-Gonzalez MA, 2014, NUTR METAB CARDIOVAS, V24, P1189, DOI 10.1016/j.numecd.2014.05.015
   Martínez-González MA, 2005, PUBLIC HEALTH NUTR, V8, P920, DOI 10.1079/PHN2005745
   Maslowski KM, 2011, NAT IMMUNOL, V12, P5, DOI 10.1038/ni0111-5
   Mehrabani M., 2013, Int. J. Enteric Pathog, V1, P53, DOI [10.17795/ijep14868, DOI 10.17795/IJEP14868]
   Miyake Y, 2015, BJOG-INT J OBSTET GY, V122, P336, DOI 10.1111/1471-0528.12972
   Naseribafrouei A, 2014, NEUROGASTROENT MOTIL, V26, P1155, DOI 10.1111/nmo.12378
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Patel R, 2015, CLIN INFECT DIS, V60, pS108, DOI 10.1093/cid/civ177
   Perez-Cornago A, 2015, AM J CLIN NUTR, V102, P1554, DOI 10.3945/ajcn.115.121202
   Perez-Cornago A, 2014, CLIN NUTR, V33, P1061, DOI 10.1016/j.clnu.2013.11.011
   Perez-Cornago A, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-36
   Rautava S, 2012, NEONATOLOGY, V102, P178, DOI 10.1159/000339182
   Roberfroid M, 2010, BRIT J NUTR, V104, pS1, DOI 10.1017/S0007114510003363
   Sanchez-Villegas A, 2015, BMC MED, V13, DOI 10.1186/s12916-015-0428-y
   Sanchez-Villegas A, 2013, BMC MED, V11, DOI [10.1186/1741-7015-11-3, 10.1186/1741-7015-11-208]
   Sanchez-Villegas A, 2008, BMC PSYCHIATRY, V8, DOI 10.1186/1471-244X-8-43
   Sanders ME, 2008, CLIN INFECT DIS, V46, pS58, DOI 10.1086/523341
   Sarris J, 2015, LANCET PSYCHIAT, V2, P271, DOI 10.1016/S2215-0366(14)00051-0
   Savard P, 2011, INT J FOOD MICROBIOL, V149, P50, DOI 10.1016/j.ijfoodmicro.2010.12.026
   Savignac HM, 2016, BRAIN BEHAV IMMUN, V52, P120, DOI 10.1016/j.bbi.2015.10.007
   Savignac HM, 2013, NEUROCHEM INT, V63, P756, DOI 10.1016/j.neuint.2013.10.006
   Schmidt K, 2015, PSYCHOPHARMACOLOGY, V232, P1793, DOI 10.1007/s00213-014-3810-0
   Seguí-Gómez M, 2006, INT J EPIDEMIOL, V35, P1417, DOI 10.1093/ije/dyl223
   Slavin J, 2013, NUTRIENTS, V5, P1417, DOI 10.3390/nu5041417
   Solomon MB, 2009, PHYSIOL BEHAV, V97, P250, DOI 10.1016/j.physbeh.2009.02.033
   Tedelind S, 2007, WORLD J GASTROENTERO, V13, P2826, DOI 10.3748/wjg.v13.i20.2826
   Tillisch K, 2013, GASTROENTEROLOGY, V144, P1394, DOI 10.1053/j.gastro.2013.02.043
   Viladomiu M, 2013, J NUTR BIOCHEM, V24, P929, DOI 10.1016/j.jnutbio.2013.01.006
   Vos T, 2015, LANCET, V386, P743, DOI 10.1016/S0140-6736(15)60692-4
   Wardle J, 2004, ANN BEHAV MED, V27, P107, DOI 10.1207/s15324796abm2702_5
   Weerathilake W. A. D. V, 2014, International Journal of Scientific and Research Publications, V4, P2250
   Willett W., 2017, Nutritional epidemiology
   Yakoob MY, 2016, CIRCULATION, V133, P1645, DOI 10.1161/CIRCULATIONAHA.115.018410
NR 56
TC 29
Z9 33
U1 0
U2 46
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD SEP
PY 2016
VL 146
IS 9
BP 1731
EP 1739
DI 10.3945/jn.116.233858
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DU7VN
UT WOS:000382422800015
PM 27466606
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Igna, CV
   Julkunen, J
   Vanhanen, H
   Keskivaara, P
   Verkasalo, M
AF Igna, Cornel Victor
   Julkunen, Juhani
   Vanhanen, Hannu
   Keskivaara, Pertti
   Verkasalo, Markku
TI Depressive Symptoms and Serum Lipid Fractions in Middle-Aged Men:
   Physiologic and Health Behavior Links
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE depression; cholesterol; HDL; LDL; cardiovascular diseases; health
   behavior
ID CORONARY-HEART-DISEASE; LIFE-STYLE FACTORS; DENSITY-LIPOPROTEIN
   CHOLESTEROL; RISK-FACTOR; CARDIOVASCULAR-DISEASE; MARITAL TRANSITIONS;
   SMOKING-BEHAVIOR; SUICIDE RISK; FOLLOW-UP; OVERWEIGHT
AB Objective: To investigate alternative hypothetical models that could clarify the relationship between depressive symptoms and serum cholesterol fractions, i.e., high-density lipoprotein (HDL) and low-density lipoprotein (LDL). It was hypothesized that the impact of the depressive symptoms on cholesterol fractions is mediated through health behavior and body mass index, and at the same time there would be a direct link from depression to cholesterol. Methods: The study sample consisted of 893 middle-age men who participated in a trial aimed at preventing the metabolic syndrome, Type 2 diabetes and cardiovascular diseases. Serum cholesterol was measured by the enzymatic method. Participants completed self-report questionnaires assessing health behavior and depressive symptoms. Results: Depressive symptoms consistently correlated statistically significantly with adverse lifestyle factors and, as hypothesized, positively with HDL. Path analyses supported the parallel existence of two main pathways: from depression through adverse health behavior to unfavorable cholesterol fraction balance, and a direct physiological link indicative of beneficial effect of depression on cholesterol levels. Conclusions: It is concluded that, among a sample of men, depressive symptoms are linked to cholesterol fractions through two different pathways. An adverse relationship of depression with serum lipids HDL-LDL balance is partly mediated through harmful health behaviors. At the same time, the results indicate a direct, physiological link between depressive symptoms and cholesterol that has a beneficial influence on the HDL-LDL balance.
C1 [Igna, Cornel Victor; Julkunen, Juhani; Keskivaara, Pertti; Verkasalo, Markku] Univ Helsinki, Dept Psychol, SF-00100 Helsinki, Finland.
   [Vanhanen, Hannu] Finnish Heart Assoc, Helsinki, Finland.
C3 University of Helsinki
RP Julkunen, J (corresponding author), Univ Helsinki, Dept Psychol, Fabianinkatu 28, SF-00100 Helsinki, Finland.
EM juhani.julkunen@helsinki.fi
OI Verkasalo, Markku/0000-0002-4356-9649
FU Finnish Slot Machine Corporation
FX The main study was funded by the Finnish Slot Machine Corporation.
   Received for publication December 10, 2007; revision received June 12,
   2008.
CR Äijänseppä S, 2002, INT J GERIATR PSYCH, V17, P629, DOI 10.1002/gps.666
   Alati R, 2005, ADDICTION, V100, P643, DOI 10.1111/j.1360-0443.2005.01063.x
   [Anonymous], ADV DATA VITAL HLTH
   Ariyo AA, 2000, CIRCULATION, V102, P1773
   Atlantis E, 2006, INT J OBESITY, V30, P1027, DOI 10.1038/sj.ijo.0803286
   Barth J, 2004, PSYCHOSOM MED, V66, P802, DOI 10.1097/01.psy.0000146332.53619.b2
   BECK AT, 1988, CLIN PSYCHOL REV, V8, P77, DOI 10.1016/0272-7358(88)90050-5
   Bots S, 2008, INT J GERIATR PSYCH, V23, P478, DOI 10.1002/gps.1919
   BROWN SL, 1994, BRIT MED J, V308, P1328, DOI 10.1136/bmj.308.6940.1328
   Carney RM, 2002, J PSYCHOSOM RES, V53, P897, DOI 10.1016/S0022-3999(02)00311-2
   Colin A, 2003, ENCEPHALE, V29, P49
   Cooper AR, 2000, EUR J CLIN NUTR, V54, P887, DOI 10.1038/sj.ejcn.1601116
   Coryell WH, 2006, CNS SPECTRUMS, V11, P455, DOI 10.1017/S109285290001467X
   Croezen S., 2007, EUR J CLIN NUTR
   Duvigneaud N, 2007, BMC PUBLIC HEALTH, V7, DOI 10.1186/1471-2458-7-23
   Egusa Genshi, 2004, J Atheroscler Thromb, V11, P304
   Enders CK, 2006, PSYCHOSOM MED, V68, P427, DOI 10.1097/01.psy.0000221275.75056.d8
   Eng PM, 2005, J EPIDEMIOL COMMUN H, V59, P56, DOI 10.1136/jech.2004.020073
   FERNSTROM MH, 1987, BIOL PSYCHIAT, V22, P529, DOI 10.1016/0006-3223(87)90180-6
   Freedland KE, 2005, PSYCHOSOM MED, V67, pS1, DOI 10.1097/01.psy.0000166753.75513.95
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Gary TL, 2000, DIABETES CARE, V23, P23, DOI 10.2337/diacare.23.1.23
   Golden SH, 2004, DIABETES CARE, V27, P429, DOI 10.2337/diacare.27.2.429
   Gump BB, 2005, STROKE, V36, P98, DOI 10.1161/01.STR.0000149626.50127.d0
   Halverstadt A, 2007, METABOLISM, V56, P444, DOI 10.1016/j.metabol.2006.10.019
   Huang TL, 2003, PSYCHIAT RES, V118, P147, DOI 10.1016/S0165-1781(03)00071-4
   John U, 2005, INT J OBESITY, V29, P1289, DOI 10.1038/sj.ijo.0803028
   Jreskog KG., 1993, LISREL 8: Structural Equation Modeling with the SIMPLIS Command Language
   Kelley GA, 2005, INT J OBESITY, V29, P881, DOI 10.1038/sj.ijo.0802959
   Ketola E, 1999, FAM PRACT, V16, P179, DOI 10.1093/fampra/16.2.179
   Kim YK, 2004, J AFFECT DISORDERS, V81, P161, DOI 10.1016/S0165-0327(03)00166-6
   Kline R.B., 2015, Principles and Practice of Structural Equation Modeling, DOI [10.15353/cgjsc.v1i1.3787, DOI 10.15353/CGJSC.V1I1.3787]
   Korhonen T, 2007, PSYCHOL MED, V37, P705, DOI 10.1017/S0033291706009639
   Kubzansky LD, 2005, PSYCHOSOM MED, V67, pS10, DOI 10.1097/01.psy.0000164012.88829.41
   Lee S, 2005, INT J EPIDEMIOL, V34, P69, DOI 10.1093/ije/dyh258
   Lett HS, 2004, PSYCHOSOM MED, V66, P305, DOI 10.1097/01.psy.0000126207.43307.c0
   Liao D, 2002, DIABETES CARE, V25, P1504, DOI 10.2337/diacare.25.9.1504
   Liu CH, 2007, PHYSIOL BEHAV, V92, P748, DOI 10.1016/j.physbeh.2007.05.068
   Manfredini R, 2000, J INT MED RES, V28, P247, DOI 10.1177/147323000002800601
   Martinez-Gonzalez MA, 1998, EUR J EPIDEMIOL, V14, P525, DOI 10.1023/A:1007402521913
   Martini S, 2002, SUBST USE MISUSE, V37, P1853, DOI 10.1081/JA-120014087
   McCaffery JM, 2003, PSYCHOSOM MED, V65, P490, DOI 10.1097/01.PSY.0000041545.52924.82
   Musselman DL, 1998, ARCH GEN PSYCHIAT, V55, P580, DOI 10.1001/archpsyc.55.7.580
   Nicholson A, 2005, PSYCHOSOM MED, V67, P522, DOI 10.1097/01.psy.0000171159.86446.9e
   Nystedt P, 2006, SOC SCI MED, V62, P1427, DOI 10.1016/j.socscimed.2005.08.009
   Pilu Alessandra, 2007, Clin Pract Epidemiol Ment Health, V3, P8, DOI 10.1186/1745-0179-3-8
   Reynolds CR, 1999, CLIN NEUROPSYCHOL, V13, P386, DOI 10.1076/1385-4046(199911)13:04;1-Y;FT386
   Sánchez-Villegas A, 2006, PUBLIC HEALTH NUTR, V9, P1104, DOI 10.1017/S1368980007668578
   Schubert CM, 2006, INT J OBESITY, V30, P251, DOI 10.1038/sj.ijo.0803129
   Smith PJ, 2007, J PSYCHOSOM RES, V63, P463, DOI 10.1016/j.jpsychores.2007.05.011
   Stefanick ML, 1998, NEW ENGL J MED, V339, P12, DOI 10.1056/NEJM199807023390103
   Strike PC, 2004, PROG CARDIOVASC DIS, V46, P337, DOI 10.1016/j.pcad.2003.09.001
   Suarez EC, 1999, PSYCHOSOM MED, V61, P273, DOI 10.1097/00006842-199905000-00004
   Suls J, 2005, PSYCHOL BULL, V131, P260, DOI 10.1037/0033-2909.131.2.260
   Wardle J, 2003, J EPIDEMIOL COMMUN H, V57, P440, DOI 10.1136/jech.57.6.440
   Woo J, 1999, EUR J CLIN NUTR, V53, P461, DOI 10.1038/sj.ejcn.1600777
   Wulsin LR, 2005, PSYCHOSOM MED, V67, P697, DOI 10.1097/01.psy.0000181274.56785.28
   Wulsin LR, 2003, PSYCHOSOM MED, V65, P201, DOI 10.1097/01.PSY.0000058371.50240.E3
   Yamamoto Akira, 2003, J Atheroscler Thromb, V10, P165
   Yang CC, 2003, ARCH INTERN MED, V163, P1926, DOI 10.1001/archinte.163.16.1926
   Yarnell J, 2005, INT J EPIDEMIOL, V34, P268, DOI 10.1093/ije/dyh267
NR 61
TC 20
Z9 26
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD NOV-DEC
PY 2008
VL 70
IS 9
BP 960
EP 966
DI 10.1097/PSY.0b013e318189a942
PG 7
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 375RE
UT WOS:000261130200002
PM 18981271
DA 2025-06-11
ER

PT J
AU Iob, E
   Steptoe, A
AF Iob, Eleonora
   Steptoe, Andrew
TI Cardiovascular Disease and Hair Cortisol: a Novel Biomarker of Chronic
   Stress
SO CURRENT CARDIOLOGY REPORTS
LA English
DT Review
DE Chronic stress; Hair cortisol; Cardiovascular disease; Cardiometabolic
   markers
ID CORONARY-HEART-DISEASE; ADRENAL-AXIS DYSREGULATION; QUALITY-OF-LIFE;
   RISK-FACTORS; SALIVARY CORTISOL; MYOCARDIAL-INFARCTION;
   DIABETES-MELLITUS; URINARY CORTISOL; BLOOD-PRESSURE; ALL-CAUSE
AB Purpose of Review This review focuses on the concentration of cortisol in human hair as a biomarker of chronic stress in cardiovascular disease (CVD). We outline the cardiovascular consequences of cortisol excess and provide a comprehensive overview of recent studies investigating the relationship of hair cortisol with CVD. In addition, clinical implications and limitations of the evidence are discussed, together with directions for future research. Recent Findings Hair cortisol may be a reliable biomarker of chronic stress since it provides quantification of total cortisol secreted into hair over several weeks. A growing body of evidence suggests that elevated hair cortisol levels are associated with both the incidence of CVD and poorer recovery and treatment outcomes. Moreover, increased hair cortisol concentration has been linked with established cardiometabolic risk factors for CVD including high blood pressure, diabetes, and adiposity. Hair cortisol is a promising biomarker of chronic cortisol excess which may contribute to both the pathogenesis and prognosis of CVD. However, the current evidence relies on small-scale cross-sectional studies. Further research adopting longitudinal designs across larger samples of CVD patients and healthy participants is required to inform the development of novel evidence-based interventions.
C1 [Iob, Eleonora; Steptoe, Andrew] UCL, Dept Behav Sci & Hlth, Gower St, London WC1E 6BT, England.
C3 University of London; University College London
RP Iob, E (corresponding author), UCL, Dept Behav Sci & Hlth, Gower St, London WC1E 6BT, England.
EM eleonora.iob.17@ucl.ac.uk; a.steptoe@ucl.ac.uk
RI Iob, Eleonora/AAF-1224-2021; Steptoe, Andrew/Y-2440-2019
OI Iob, Eleonora/0000-0003-3617-0266
FU ESRC-BBSRC Soc-B Centre for Doctoral Training [ES/P000347/1]; ESRC
   [1907703] Funding Source: UKRI
FX E. Iob is supported by the ESRC-BBSRC Soc-B Centre for Doctoral Training
   (ES/P000347/1).
CR Abell JG, 2016, PSYCHONEUROENDOCRINO, V73, P148, DOI 10.1016/j.psyneuen.2016.07.214
   Adam EK, 2017, PSYCHONEUROENDOCRINO, V83, P25, DOI 10.1016/j.psyneuen.2017.05.018
   Adam EK, 2009, PSYCHONEUROENDOCRINO, V34, P1423, DOI 10.1016/j.psyneuen.2009.06.011
   Aguilera G, 2012, HANDBOOK OF NEUROENDOCRINOLOGY, P175, DOI 10.1016/B978-0-12-375097-6.10008-3
   Al-Kubaisy W, 2012, PROCD SOC BEHV, V38, P59, DOI 10.1016/j.sbspro.2012.03.324
   [Anonymous], 2024, IDEXEB/OL
   Argentieri MA, 2017, EBIOMEDICINE, V18, P327, DOI 10.1016/j.ebiom.2017.03.044
   Arnold SV, 2012, J AM COLL CARDIOL, V60, P1756, DOI 10.1016/j.jacc.2012.06.044
   Barahona M-J, 2015, PANVASCULAR MED, P4641
   Barth J, 2010, PSYCHOSOM MED, V72, P229, DOI 10.1097/PSY.0b013e3181d01611
   Barugh AJ, 2014, J NEUROL, V261, P533, DOI 10.1007/s00415-013-7231-5
   Ben Assayag E, 2017, PSYCHONEUROENDOCRINO, V82, P133, DOI 10.1016/j.psyneuen.2017.05.013
   Bennett DA, 2017, HEART, V103, P1400, DOI 10.1136/heartjnl-2016-310605
   Bhattacharyya MR, 2008, J PSYCHOSOM RES, V65, P107, DOI 10.1016/j.jpsychores.2008.03.012
   Bolton JL, 2014, PLOS GENET, V10, DOI 10.1371/journal.pgen.1004474
   Bossé S, 2018, PSYCHOSOM MED, V80, P393, DOI 10.1097/PSY.0000000000000569
   Celano CM, 2015, AM HEART J, V170, P1105, DOI 10.1016/j.ahj.2015.09.013
   Champaneri S, 2012, METABOLISM, V61, P986, DOI 10.1016/j.metabol.2011.11.006
   Colledge F, 2017, NEUROPSYCHOBIOLOGY, V75, P12, DOI 10.1159/000477966
   Crawford AA, 2015, HEART, V101, pA6, DOI 10.1136/heartjnl-2015-308734.19
   Dekker MJHJ, 2008, J CLIN ENDOCR METAB, V93, P3741, DOI 10.1210/jc.2008-0496
   Dowlati Y, 2010, NEUROPSYCH DIS TREAT, V6, P393
   Ezzati M, 2015, NAT REV CARDIOL, V12, P508, DOI 10.1038/nrcardio.2015.82
   Feller S, 2014, PSYCHONEUROENDOCRINO, V39, P132, DOI 10.1016/j.psyneuen.2013.10.007
   Fluharty M, 2017, NICOTINE TOB RES, V19, P3, DOI 10.1093/ntr/ntw140
   Fransson EI, 2012, AM J EPIDEMIOL, V176, P1078, DOI 10.1093/aje/kws336
   Fuchs A, 2018, PSYCHONEUROENDOCRINO, V90, P52, DOI 10.1016/j.psyneuen.2018.02.003
   Gan Y, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/s12888-014-0371-z
   Girod JP, 2004, CARDIOVASC RES, V64, P217, DOI 10.1016/j.cardiores.2004.07.006
   Goldberg SB, 2014, J ALTERN COMPLEM MED, V20, P630, DOI 10.1089/acm.2014.0080
   Greff MJE, 2019, CLIN BIOCHEM, V63, P1, DOI 10.1016/j.clinbiochem.2018.09.010
   Hackett RA, 2017, NAT REV ENDOCRINOL, V13, P547, DOI 10.1038/nrendo.2017.64
   Hackett RA, 2016, J CLIN ENDOCR METAB, V101, P619, DOI 10.1210/jc.2015-2853
   Hackett RA, 2014, J CLIN ENDOCR METAB, V99, P4625, DOI 10.1210/jc.2014-2459
   Hamer Mark, 2012, PLoS One, V7, pe31356, DOI 10.1371/journal.pone.0031356
   Hamer M, 2012, J CLIN ENDOCR METAB, V97, pE29, DOI 10.1210/jc.2011-2132
   Henley P, 2013, THER DRUG MONIT, V35, P595, DOI 10.1097/FTD.0b013e318292eb84
   Hughes K, 2017, LANCET PUBLIC HEALTH, V2, pE356, DOI 10.1016/S2468-2667(17)30118-4
   Hughes MF, 2018, FRONT CARDIOVASC MED, V5, DOI 10.3389/fcvm.2018.00148
   Iob E, 2018, PSYCHONEUROENDOCRINO, V96, P100, DOI 10.1016/j.psyneuen.2018.06.008
   Ito N, 2005, FASEB J, V19, P1332, DOI 10.1096/fj.04-1968fje
   Izawa S, 2019, PSYCHONEUROENDOCRINO, V101, P240, DOI 10.1016/j.psyneuen.2018.11.021
   Khoury JE, 2019, PSYCHONEUROENDOCRINO, V103, P104, DOI 10.1016/j.psyneuen.2019.01.009
   Kirschbaum C, 2009, PSYCHONEUROENDOCRINO, V34, P32, DOI 10.1016/j.psyneuen.2008.08.024
   Kivimäki M, 2018, NAT REV CARDIOL, V15, P215, DOI 10.1038/nrcardio.2017.189
   Kivimäki M, 2017, LANCET PUBLIC HEALTH, V2, pE277, DOI 10.1016/S2468-2667(17)30074-9
   Kuehl LK, 2015, PSYCHONEUROENDOCRINO, V51, P365, DOI 10.1016/j.psyneuen.2014.09.012
   Kumari M, 2011, J CLIN ENDOCR METAB, V96, P1478, DOI 10.1210/jc.2010-2137
   Kunz-Ebrecht SR, 2003, BRAIN BEHAV IMMUN, V17, P373, DOI 10.1016/S0889-1591(03)00029-1
   Landsbergis PA, 2013, AM J PUBLIC HEALTH, V103, pE61, DOI 10.2105/AJPH.2012.301153
   Larkin K.T., 2005, Stress and hypertension: Examining the relation between psychological stress and high blood pressure
   Lehrer HM, 2016, PSYCHONEUROENDOCRINO, V72, P212, DOI 10.1016/j.psyneuen.2016.06.018
   Lewington S, 2002, LANCET, V360, P1903, DOI 10.1016/S0140-6736(02)11911-8
   Lewington S, 2007, LANCET, V370, P1829, DOI 10.1016/S0140-6736(07)61778-4
   Liu H, 2005, CLIN ENDOCRINOL, V63, P642, DOI 10.1111/j.1365-2265.2005.02395.x
   Lupoli R, 2017, ANN MED, V49, P206, DOI 10.1080/07853890.2016.1252055
   Malan L, 2017, HYPERTENS RES, V40, P590, DOI 10.1038/hr.2017.5
   Manenschijn L, 2013, J CLIN ENDOCR METAB, V98, P2078, DOI 10.1210/jc.2012-3663
   Mazgelyte E, 2019, MED SCI MONITOR, V25, P3573, DOI 10.12659/MSM.913532
   McEwen BS, 2007, PHYSIOL REV, V87, P873, DOI 10.1152/physrev.00041.2006
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   Meijer A, 2011, GEN HOSP PSYCHIAT, V33, P203, DOI 10.1016/j.genhosppsych.2011.02.007
   Merswolken M, 2013, INT J BEHAV MED, V20, P461, DOI 10.1007/s12529-012-9233-6
   Mons U, 2015, BMJ-BRIT MED J, V350, DOI 10.1136/bmj.h1551
   Moraes LJ, 2018, PSYCHOL HEALTH MED, V23, P635, DOI 10.1080/13548506.2017.1417607
   Naghavi M, 2017, LANCET, V390, P1151, DOI 10.1016/S0140-6736(17)32152-9
   Nijm J, 2007, J INTERN MED, V262, P375, DOI 10.1111/j.1365-2796.2007.01817.x
   Pascoe MC, 2017, PSYCHONEUROENDOCRINO, V86, P152, DOI 10.1016/j.psyneuen.2017.08.008
   Pascoe MC, 2017, J PSYCHIATR RES, V95, P156, DOI 10.1016/j.jpsychires.2017.08.004
   Pereg D, 2013, PSYCHONEUROENDOCRINO, V38, P2875, DOI 10.1016/j.psyneuen.2013.07.015
   Pereg D, 2011, STRESS, V14, P73, DOI 10.3109/10253890.2010.511352
   Phillips AC, 2010, EUR J ENDOCRINOL, V163, P285, DOI 10.1530/EJE-10-0299
   Pivonello R, 2016, LANCET DIABETES ENDO, V4, P611, DOI 10.1016/S2213-8587(16)00086-3
   Ragnarsson O, 2015, STEROIDS, V101, P71, DOI 10.1016/j.steroids.2015.06.007
   Raul JS, 2004, CLIN BIOCHEM, V37, P1105, DOI 10.1016/j.clinbiochem.2004.02.010
   Reynolds RM, 2009, QJM-INT J MED, V102, P469, DOI 10.1093/qjmed/hcp057
   Reynolds RM, 2010, J CLIN ENDOCR METAB, V95, P1602, DOI 10.1210/jc.2009-2112
   Reynolds RM, 2010, CRIT CARE MED, V38, P973, DOI 10.1097/CCM.0b013e3181cdf6de
   Richards SH, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD002902.pub4
   Rod NH, 2010, INT J EPIDEMIOL, V39, P530, DOI 10.1093/ije/dyp354
   Rodriguez ACI, 2015, PSYCHONEUROENDOCRINO, V62, P301, DOI 10.1016/j.psyneuen.2015.08.014
   Russell E, 2015, THER DRUG MONIT, V37, P71, DOI 10.1097/FTD.0000000000000148
   Russell E, 2012, PSYCHONEUROENDOCRINO, V37, P589, DOI 10.1016/j.psyneuen.2011.09.009
   Saleem Mahwesh, 2013, Cardiovasc Psychiatry Neurol, V2013, P340342, DOI 10.1155/2013/340342
   Sapolsky RM, 2000, ENDOCR REV, V21, P55, DOI 10.1210/er.21.1.55
   Sarwar N, 2010, LANCET, V375, P2215, DOI 10.1016/s0140-6736(10)60484-9
   Sauve B, 2007, CLIN INVEST MED, V30, pE183, DOI 10.25011/cim.v30i5.2894
   Schoorlemmer RMM, 2009, CLIN ENDOCRINOL, V71, P779, DOI 10.1111/j.1365-2265.2009.03552.x
   Smith GD, 2005, CIRCULATION, V112, P332, DOI 10.1161/CIRCULATIONAHA.104.489088
   Stalder T, 2017, PSYCHONEUROENDOCRINO, V77, P261, DOI 10.1016/j.psyneuen.2016.12.017
   Stalder T, 2013, J CLIN ENDOCR METAB, V98, P2573, DOI 10.1210/jc.2013-1056
   Stalder T, 2012, BRAIN BEHAV IMMUN, V26, P1019, DOI 10.1016/j.bbi.2012.02.002
   Staufenbiel SM, 2015, PSYCHONEUROENDOCRINO, V60, P182, DOI 10.1016/j.psyneuen.2015.06.011
   Staufenbiel SM, 2013, PSYCHONEUROENDOCRINO, V38, P1220, DOI 10.1016/j.psyneuen.2012.11.015
   Steptoe A, 2017, PSYCHONEUROENDOCRINO, V86, P122, DOI 10.1016/j.psyneuen.2017.09.016
   Turpeinen U, 2013, BEST PRACT RES CL EN, V27, P795, DOI 10.1016/j.beem.2013.10.008
   Twohig-Bennett C, 2018, ENVIRON RES, V166, P628, DOI 10.1016/j.envres.2018.06.030
   Ullian ME, 1999, CARDIOVASC RES, V41, P55, DOI 10.1016/S0008-6363(98)00230-2
   Valtorta NK, 2016, HEART, V102, P1009, DOI 10.1136/heartjnl-2015-308790
   van Ockenburg SL, 2016, ATHEROSCLEROSIS, V248, P44, DOI 10.1016/j.atherosclerosis.2016.02.030
   Virtanen M, 2018, CURR CARDIOL REP, V20, DOI 10.1007/s11886-018-1049-9
   Vogelzangs N, 2010, J CLIN ENDOCR METAB, V95, P4959, DOI 10.1210/jc.2010-0192
   Vreeburg SA, 2009, PSYCHONEUROENDOCRINO, V34, P1109, DOI 10.1016/j.psyneuen.2009.04.024
   Wahid A, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.115.002495
   Walker BR, 2007, EUR J ENDOCRINOL, V157, P545, DOI 10.1530/EJE-07-0455
   Wardle J, 2011, OBESITY, V19, P771, DOI 10.1038/oby.2010.241
   Wei L, 2004, ANN INTERN MED, V141, P764, DOI 10.7326/0003-4819-141-10-200411160-00007
   Wester VL, 2017, PSYCHONEUROENDOCRINO, V80, P1, DOI 10.1016/j.psyneuen.2017.02.024
   Wester VL, 2015, EUR J ENDOCRINOL, V173, pM1, DOI 10.1530/EJE-15-0313
   Whitworth Judith A, 2005, Vasc Health Risk Manag, V1, P291, DOI 10.2147/vhrm.2005.1.4.291
   Wright KD, 2015, GERONTOLOGIST, V55, pS140, DOI 10.1093/geront/gnu174
   Younge JO, 2015, INT J CARDIOL, V184, P71, DOI 10.1016/j.ijcard.2015.02.005
NR 112
TC 124
Z9 143
U1 2
U2 60
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1523-3782
EI 1534-3170
J9 CURR CARDIOL REP
JI Curr. Cardiol. Rep.
PD OCT
PY 2019
VL 21
IS 10
AR 116
DI 10.1007/s11886-019-1208-7
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA IU8RQ
UT WOS:000483849600005
PM 31471749
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Barbosa-Leiker, C
   Roper, V
   McPherson, S
   Lei, M
   Wright, B
   Hoekstra, T
   Kostick, M
AF Barbosa-Leiker, Celestina
   Roper, Virginia
   McPherson, Sterling
   Lei, Ming
   Wright, Bruce
   Hoekstra, Trynke
   Kostick, Marylynne
TI Cross-sectional and Longitudinal Relationships between Perceived Stress
   and C-reactive Protein in Men and Women
SO STRESS AND HEALTH
LA English
DT Article
DE C-reactive protein; inflammation; perceived stress
ID CARDIOVASCULAR RISK-FACTORS; CYTOKINE PRODUCTION; METABOLIC SYNDROME;
   SEX-DIFFERENCES; OLDER-ADULTS; INFLAMMATION; DISEASE; SENSITIVITY;
   EVENTS; HEALTH
AB To date, an examination of the longitudinal relationship between perceived stress and C-reactive protein (CRP) is limited. We explored the relationship between perceived stress and CRP concurrently and across 2 and 4 years in 383 men and women. Multiple linear regressions examined the cross-sectional and longitudinal relationships between baseline stress and counter-stress scores with CRP at baseline, 2 years after baseline and 4 years after baseline, while controlling for covariates (age, smoking status, anti-inflammatory use, oral contraceptive use, physical activity, menopausal status, years since onset of menopause, post-menopausal hormone use and body mass index). Results indicate that stress and counter-stress were not related to CRP in either men or women at study baseline or 2 years later. Across a 4-year time frame, higher stress values were related to higher CRP values in women, but not men. Counter-stress was not related to CRP values in men or women across the 4 years. This study highlights the importance of examining the cross-sectional and longitudinal relationship between perceived stress and inflammation separately in men and women. Copyright (C) 2013 John Wiley & Sons, Ltd.
C1 [Barbosa-Leiker, Celestina; McPherson, Sterling] Washington State Univ, Coll Nursing, Spokane, WA 99210 USA.
   [Barbosa-Leiker, Celestina; McPherson, Sterling] Washington State Univ, Dept Psychol, Pullman, WA 99164 USA.
   [Roper, Virginia] SUNY Upstate Med Univ, Syracuse, NY 13210 USA.
   [Lei, Ming] Washington State Univ, Edward R Murrow Coll Commun, Pullman, WA 99164 USA.
   [Wright, Bruce] Washington State Univ, Pullman, WA 99164 USA.
   [Hoekstra, Trynke] Vrije Univ Amsterdam, Dept Hlth Sci, Amsterdam, Netherlands.
   [Hoekstra, Trynke] Vrije Univ Amsterdam, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
   [Hoekstra, Trynke] Vrije Univ Amsterdam, Med Ctr, Dept Epidemiol & Biostat, Amsterdam, Netherlands.
   [Hoekstra, Trynke] Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
   [Kostick, Marylynne] Univ Alaska Anchorage, Dept Hlth Sci, Anchorage, AK USA.
C3 Washington State University; Washington State University; State
   University of New York (SUNY) System; State University of New York
   (SUNY) Upstate Medical Center; Washington State University; Washington
   State University; Vrije Universiteit Amsterdam; Vrije Universiteit
   Amsterdam; Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam;
   University of Alaska System; University of Alaska Anchorage
RP Barbosa-Leiker, C (corresponding author), Washington State Univ, Coll Nursing, POB 1495, Spokane, WA 99210 USA.
EM celestina@wsu.edu
RI Wright, Bruce/R-6107-2019; Hoekstra, Trynke/AAG-5901-2020
OI Hoekstra, Trynke/0000-0002-0535-0056
FU E. L. Wiegand Foundation; Washington State University; Providence
   Medical Research Center; Sacred Heart Medical Center
FX The authors would like to thank C. Harold Mielke, MD, J. Paul Shields,
   MD, Dennis Dyck, PhD, and all other members of the Spokane Heart Study
   Steering Committee. Funding sources for the Spokane Heart Study have
   included the E. L. Wiegand Foundation, Washington State University,
   Providence Medical Research Center and Sacred Heart Medical Center.
CR An XQ, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-71
   Asegaonkar SB, 2011, J DIABETES COMPLICAT, V25, P368, DOI 10.1016/j.jdiacomp.2011.10.001
   Bajaj M, 2006, J AM COLL CARDIOL, V48, P1163, DOI 10.1016/j.jacc.2006.06.039
   Barbosa-Leiker C, 2013, STRESS HEALTH, V29, P253, DOI 10.1002/smi.2463
   Barbosa-Leiker C, 2011, ANN EPIDEMIOL, V21, P111, DOI 10.1016/j.annepidem.2010.10.001
   Ben-Yehuda O, 2007, J AM COLL CARDIOL, V49, P2139, DOI 10.1016/j.jacc.2007.04.007
   Black PH, 2002, BRAIN BEHAV IMMUN, V16, P622, DOI 10.1016/S0889-1591(02)00021-1
   Black PH, 2002, J PSYCHOSOM RES, V52, P1, DOI 10.1016/S0022-3999(01)00302-6
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   COHEN S, 1988, CLAR SYMP, P31
   Cushman M, 1999, CIRCULATION, V100, P717, DOI 10.1161/01.CIR.100.7.717
   Datta S, 2011, INDIAN J CLIN BIOCHE, V26, P210, DOI 10.1007/s12291-010-0100-4
   Enders CK, 2001, STRUCT EQU MODELING, V8, P128, DOI 10.1207/S15328007SEM0801_7
   Folkman S, 1997, SOC SCI MED, V45, P1207, DOI 10.1016/S0277-9536(97)00040-3
   Golden-Kreutz DM, 2004, ASSESSMENT, V11, P216, DOI 10.1177/1073191104267398
   Greenfield JR, 2004, CIRCULATION, V109, P3022, DOI 10.1161/01.CIR.0000130640.77501.79
   Hapuarachchi JR, 2003, BEHAV MED, V29, P52, DOI 10.1080/08964280309596057
   HEWITT PL, 1992, J PSYCHOPATHOL BEHAV, V14, P247, DOI 10.1007/BF00962631
   Khera A, 2005, J AM COLL CARDIOL, V46, P464, DOI 10.1016/j.jacc.2005.04.051
   Kudielka BM, 2005, BIOL PSYCHOL, V69, P113, DOI 10.1016/j.biopsycho.2004.11.009
   Lazarus R. S., 1984, Stress, appraisal, and coping, DOI [10.1007/978-3-030-39903-0_215, DOI 10.1007/978-1-4419-1005-9_215]
   Levitzky YS, 2008, ATHEROSCLEROSIS, V201, P217, DOI 10.1016/j.atherosclerosis.2007.12.058
   Lutgendorf SK, 2003, BRAIN BEHAV IMMUN, V17, P225, DOI 10.1016/S0889-1591(03)00033-3
   Main LC, 2009, RES SPORTS MED, V17, P121, DOI 10.1080/15438620802689757
   MARTIN RA, 1995, J PSYCHOPATHOL BEHAV, V17, P81, DOI 10.1007/BF02229205
   McDade TW, 2006, PSYCHOSOM MED, V68, P376, DOI 10.1097/01.psy.0000221371.43607.64
   MCEWEN BS, 1993, ARCH INTERN MED, V153, P2093, DOI 10.1001/archinte.153.18.2093
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   Mendall MA, 1996, BRIT MED J, V312, P1061
   Mielke C., 1999, CVD Prevention, V2, P194
   Mora S, 2009, CLIN CHEM, V55, P219, DOI 10.1373/clinchem.2008.109728
   Ostwald SK, 2009, TOP STROKE REHABIL, V16, P93, DOI 10.1310/tsr1602-93
   Paul K, 2008, J NATL MED ASSOC, V100, P540, DOI 10.1016/S0027-9684(15)31300-6
   Pearson TA, 2003, CIRCULATION, V107, P499, DOI 10.1161/01.CIR.0000052939.59093.45
   Pu LJ, 2006, CARDIOVASC DIABETOL, V5, DOI 10.1186/1475-2840-5-27
   Ridker PM, 1999, CIRCULATION, V100, P713, DOI 10.1161/01.CIR.100.7.713
   Ridker PM, 1997, NEW ENGL J MED, V336, P973, DOI 10.1056/NEJM199704033361401
   Ridker PM, 2002, NEW ENGL J MED, V347, P1557, DOI 10.1056/NEJMoa021993
   Roberti JW, 2006, J COLL COUNS, V9, P135, DOI 10.1002/j.2161-1882.2006.tb00100.x
   Rohleder N, 2001, PSYCHOSOM MED, V63, P966, DOI 10.1097/00006842-200111000-00016
   Ross R, 1999, AM HEART J, V138, pS419, DOI 10.1016/S0002-8703(99)70266-8
   Rutter MK, 2004, CIRCULATION, V110, P380, DOI 10.1161/01.CIR.0000136581.59584.0E
   Smith T., 2002, HDB CLIN HLTH PSYCHO
   Stowell JR, 2001, J BEHAV MED, V24, P323, DOI 10.1023/A:1010630801589
   Tuttle KR, 2009, CLIN J AM SOC NEPHRO, V4, P1968, DOI 10.2215/CJN.01250209
   Vieira VJ, 2007, J AM GERIATR SOC, V55, P747, DOI 10.1111/j.1532-5415.2007.01160.x
   Visser M, 1999, JAMA-J AM MED ASSOC, V282, P2131, DOI 10.1001/jama.282.22.2131
   Wong N D, 2001, Prev Cardiol, V4, P109, DOI 10.1111/j.1520-037X.2001.00570.x
   Wright BR, 2011, J OCCUP ENVIRON MED, V53, P730, DOI 10.1097/JOM.0b013e318220c2da
   Yudkin JS, 2000, ATHEROSCLEROSIS, V148, P209, DOI 10.1016/S0021-9150(99)00463-3
NR 50
TC 10
Z9 11
U1 0
U2 19
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1532-3005
EI 1532-2998
J9 STRESS HEALTH
JI Stress Health
PD APR
PY 2014
VL 30
IS 2
BP 158
EP 165
DI 10.1002/smi.2507
PG 8
WC Psychology, Applied; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA AJ2JO
UT WOS:000337482100009
PM 23818431
DA 2025-06-11
ER

PT J
AU Dehghan, P
   Pourmoradian, S
   Mahdavi, AM
   Sarmadi, B
   Mehralizadeh, S
AF Dehghan, Parvin
   Pourmoradian, Samira
   Mahdavi, Aida Malek
   Sarmadi, Bahareh
   Mehralizadeh, Sajjad
TI RELATIONSHIP BETWEEN PERCEIVED STRESS AND DIETARY INTAKES IN TYPE 2
   DIABETIC PATIENTS
SO CURRENT TOPICS IN NUTRACEUTICAL RESEARCH
LA English
DT Article
DE Diet; Micronutrients; Perceived stress; Type 2 diabetes.
ID FOOD-INTAKE; EATING BEHAVIOR; HEALTH BEHAVIORS; METABOLIC SYNDROME;
   COLLEGE-STUDENTS; CONTROLLED-TRIAL; DOUBLE-BLIND; ADULT MALES; MOOD;
   WOMEN
AB As the major aspect of lifestyle, dietary patterns are concerned with health issues in all conditions including stress. Studies on the association between stress and food choices have resulted conflicting outcomes. This cross-sectional study was conducted on a sample of type 2 diabetic patients (n = 200) who met the inclusion criteria. A 14-item questionnaire was used to measure the perceived stress. Food recall was recorded by a trained dietitian for 24 hours over 2 regular days and 1 holiday. Liner regression results indicated that negative perceived stress had association with carbohydrate intake (B=0.246, P=0.04) which for the Positive perceived stress it was directly associated with mean protein (B=0.14, P=0.04) and fiber intakes (B=0.46, P=0.001). Based on the finding, there was a relationship between micronutrient intake and positive perceived stress. Positive perceived stress leads to healthy food choices while negative perceived stress leads to the unhealthy dietary patterns. A diet with adequate vitamin B complex, vitamin E and antioxidant minerals (selenium, zinc, copper, magnesium) may have positive effects in coping with stress and help positive interpretation of stressful events.
C1 [Dehghan, Parvin] Tabriz Univ Med Sci, Fac Nutr, Nutr Res Ctr, Student Res Comm, Tabriz, Iran.
   [Pourmoradian, Samira] Shahid Beheshti Univ Med Sci & Hlth Serv, Fac Nutr & Food Technol, Dept Community Nutr, Tehran, Iran.
   [Mahdavi, Aida Malek] Tabriz Univ Med Sci, Connect Tissue Dis Res Ctr, Tabriz, Iran.
   [Sarmadi, Bahareh] Dept Nutr & Dietet, Putrajaya, Selangor, Malaysia.
   [Mehralizadeh, Sajjad] Tabriz Univ Med Sci, Tabriz, Iran.
C3 Tabriz University of Medical Science; Shahid Beheshti University Medical
   Sciences; Tabriz University of Medical Science; Tabriz University of
   Medical Science
RP Pourmoradian, S (corresponding author), Shahid Beheshti Univ Med Sci & Hlth Serv, Fac Nutr & Food Technol, Dept Community Nutr, Tehran, Iran.
EM samira.pourmoradian@gmail.com
RI pourmoradian, samira/ABC-8141-2021; Mahdavi, Aida/N-3109-2017; Sarmadi,
   Bahareh/G-1773-2017; Dehghan, Parvin/G-3885-2015
OI Dehghan, Parvin/0000-0001-8929-3302
FU Nutrition Research center; Tabriz University of Medical Sciences
FX The authors are grateful for the financial support of the Nutrition
   Research center, Tabriz University of Medical Sciences. The authors also
   are deeply indebted to all the patients who participated in this study.
CR Abubakari AR, 2008, PUBLIC HEALTH, V122, P173, DOI 10.1016/j.puhe.2007.06.012
   Adams T, 2007, J AM COLL HEALTH, V55, P361, DOI 10.3200/JACH.55.6.361-366
   Aliasgharzadeh A, 2015, BRIT J NUTR, V113, P321, DOI 10.1017/S0007114514003675
   ANISMAN H, 1992, BRIT J PSYCHIAT, V160, P36, DOI 10.1192/S0007125000296669
   Bao B, 2010, AM J CLIN NUTR, V91, P1634, DOI 10.3945/ajcn.2009.28836
   BELLISLE F, 1990, PSYCHOSOM MED, V52, P452, DOI 10.1097/00006842-199007000-00007
   Benton D, 2002, NEUROSCI BIOBEHAV R, V26, P293, DOI 10.1016/S0149-7634(02)00004-0
   Benton D, 1999, PUBLIC HEALTH NUTR, V2, P403, DOI 10.1017/S1368980099000555
   BERNSTEIN AL, 1990, ANN NY ACAD SCI, V585, P250
   Canetti L, 2002, BEHAV PROCESS, V60, P157, DOI 10.1016/S0376-6357(02)00082-7
   Christensen L, 2001, APPETITE, V36, P137, DOI 10.1006/appe.2001.0390
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Conner M, 1999, PSYCHOL HEALTH, V14, P51, DOI 10.1080/08870449908407313
   DEIJEN JB, 1989, J PSYCHIATR RES, V23, P275, DOI 10.1016/0022-3956(89)90033-2
   DELBENDE C, 1992, BRIT J PSYCHIAT, V160, P24, DOI 10.1192/S0007125000296657
   Epel E, 2001, PSYCHONEUROENDOCRINO, V26, P37, DOI 10.1016/S0306-4530(00)00035-4
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   Frederickson CJ, 2000, J NUTR, V130, p1471S, DOI 10.1093/jn/130.5.1471S
   Gibson EL, 2002, NUTR RES REV, V15, P169, DOI 10.1079/NRR200131
   Glade MJ, 2010, NUTRITION, V26, P595, DOI 10.1016/j.nut.2009.09.014
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Hadaegh F, 2008, BMC PUBLIC HEALTH, V8, DOI 10.1186/1471-2458-8-176
   Hellerstedt WL, 1997, INT J EPIDEMIOL, V26, P575, DOI 10.1093/ije/26.3.575
   Holick MF, 2007, NEW ENGL J MED, V357, P266, DOI 10.1056/NEJMra070553
   Hu FB, 2001, NEW ENGL J MED, V345, P790, DOI 10.1056/NEJMoa010492
   Hwang JY, 2010, J AM DIET ASSOC, V110, P779, DOI 10.1016/j.jada.2010.02.004
   Kandiah J, 2006, NUTR RES, V26, P118, DOI 10.1016/j.nutres.2005.11.010
   Karimi P, 2016, ANN NUTR METAB, V68, P85, DOI 10.1159/000441683
   KATZ RL, 1987, J ADOLESCENT HEALTH, V8, P400, DOI 10.1016/0197-0070(87)90227-0
   Liu CH, 2007, PHYSIOL BEHAV, V92, P748, DOI 10.1016/j.physbeh.2007.05.068
   Maes Michael, 1995, P933
   Markus CR, 1998, APPETITE, V31, P49, DOI 10.1006/appe.1997.0155
   Markus R, 2000, PHYSIOL BEHAV, V70, P333, DOI 10.1016/S0031-9384(00)00265-1
   MCCANN BS, 1990, PSYCHOSOM MED, V52, P97, DOI 10.1097/00006842-199001000-00008
   MCLEAN RM, 1994, AM J MED, V96, P63, DOI 10.1016/0002-9343(94)90117-1
   MCLOUGHLIN IJ, 1990, ACTA PSYCHIAT SCAND, V82, P451, DOI 10.1111/j.1600-0447.1990.tb03077.x
   MICHAUD C, 1990, STRESS MEDICINE, V6, P57, DOI 10.1002/smi.2460060112
   Mikolajczyk RT, 2009, NUTR J, V8, DOI 10.1186/1475-2891-8-31
   Mokhber N, 2011, J MATERN-FETAL NEO M, V24, P104, DOI 10.3109/14767058.2010.482598
   MULLER DPR, 1983, LANCET, V1, P225
   Ness AR, 2003, NUTR NEUROSCI, V6, P63, DOI 10.1080/1028415021000056069
   Ng DM, 2003, HEALTH PSYCHOL, V22, P638, DOI 10.1037/0278-6133.22.6.638
   O'Connor DB, 2004, STRESS HEALTH, V20, P279, DOI 10.1002/smi.1028
   Oliver G, 1999, PHYSIOL BEHAV, V66, P511, DOI 10.1016/S0031-9384(98)00322-9
   Patel KA, 2001, APPETITE, V36, P111, DOI 10.1006/appe.2000.0385
   Pollard TM, 1995, INT J BEHAV MED, V2, P299, DOI 10.1207/s15327558ijbm0204_2
   Prasad C, 1998, BRAZ J MED BIOL RES, V31, P1517, DOI 10.1590/S0100-879X1998001200002
   SanlIer N., 2007, Pakistan Journal of Nutrition, V6, P339
   Schlebusch L, 2000, S AFR MED J, V90, P1216
   SEELIG MS, 1994, J AM COLL NUTR, V13, P429
   Shahar A, 2010, MOVEMENT DISORD, V25, P1909, DOI 10.1002/mds.23218
   Singh U, 2004, ANN NY ACAD SCI, V1031, P195, DOI 10.1196/annals.1331.019
   SPRING B, 1987, PSYCHOL BULL, V102, P234, DOI 10.1037/0033-2909.102.2.234
   STONE AA, 1994, PSYCHOL HEALTH, V9, P425, DOI 10.1080/08870449408407469
   Timonen M, 2007, PSYCHOSOM MED, V69, P723, DOI 10.1097/PSY.0b013e318157ad2e
   Tsaluchidu S, 2008, BMC PSYCHIATRY, V8, DOI 10.1186/1471-244X-8-S1-S5
   Wallis DJ, 2009, APPETITE, V52, P355, DOI 10.1016/j.appet.2008.11.007
   Wallis DJ, 2004, APPETITE, V43, P39, DOI 10.1016/j.appet.2004.02.001
   Wardle J, 2000, J PSYCHOSOM RES, V48, P195, DOI 10.1016/S0022-3999(00)00076-3
   Weidner G, 1996, ANXIETY STRESS COPIN, V9, P123, DOI 10.1080/10615809608249396
   Xu Q, 2009, AM J CLIN NUTR, V89, P1857, DOI 10.3945/ajcn.2008.26986
   Zellner DA, 2006, PHYSIOL BEHAV, V87, P789, DOI 10.1016/j.physbeh.2006.01.014
NR 62
TC 2
Z9 2
U1 1
U2 9
PU NEW CENTURY HEALTH PUBLISHERS, LLC
PI COPPELL
PA PO BOX 175, COPPELL, TX 75019 USA
SN 1540-7535
J9 CURR TOP NUTRACEUT R
JI Curr. Top. Nutraceutical Res.
PD AUG
PY 2016
VL 14
IS 3
BP 199
EP 205
PG 7
WC Nutrition & Dietetics; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics; Pharmacology & Pharmacy
GA DY2SS
UT WOS:000384942900003
DA 2025-06-11
ER

PT J
AU Kühnel, A
   Hagenberg, J
   Knauer-Arloth, J
   Ködel, M
   Czisch, M
   Sämann, PG
   Binder, EB
   Kroemer, NB
AF Kuehnel, Anne
   Hagenberg, Jonas
   Knauer-Arloth, Janine
   Koedel, Maik
   Czisch, Michael
   Saemann, Philipp G.
   Binder, Elisabeth B.
   Kroemer, Nils B.
CA BeCOME Working Grp
TI Stress-induced brain responses are associated with BMI in women
SO COMMUNICATIONS BIOLOGY
LA English
DT Article
ID ACUTE PSYCHOSOCIAL STRESS; BODY-MASS INDEX; SEX-DIFFERENCES; FUNCTIONAL
   CONNECTIVITY; GENDER-DIFFERENCES; METABOLIC-SYNDROME; LIMBIC SYSTEM;
   HPA-AXIS; OBESITY; CORTISOL
AB Overweight and obesity are associated with altered stress reactivity and increased inflammation. However, it is not known whether stress-induced changes in brain function scale with BMI and if such associations are driven by peripheral cytokines. Here, we investigate multimodal stress responses in a large transdiagnostic sample using predictive modeling based on spatio-temporal profiles of stress-induced changes in activation and functional connectivity. BMI is associated with increased brain responses as well as greater negative affect after stress and individual response profiles are associated with BMI in females (p(perm)<0.001), but not males. Although stress-induced changes reflecting BMI are associated with baseline cortisol, there is no robust association with peripheral cytokines. To conclude, alterations in body weight and energy metabolism might scale acute brain responses to stress more strongly in females compared to males, echoing observational studies. Our findings highlight sex-dependent associations of stress with differences in endocrine markers, largely independent of peripheral inflammation.
   In humans, brain responses to stress are associated with their body mass index, driven mostly by females. Predictive modeling showed that this link was better explained by changes in endocrine instead of immune systems.
C1 [Kuehnel, Anne; Kroemer, Nils B.] Univ Bonn, Sect Med Psychol, Dept Psychiat & Psychotherapy, Fac Med, Bonn, Germany.
   [Kuehnel, Anne; Hagenberg, Jonas; Knauer-Arloth, Janine; Koedel, Maik; Binder, Elisabeth B.] Max Planck Inst Psychiat, Dept Translat Res Psychiat, Munich, Germany.
   [Kuehnel, Anne; Hagenberg, Jonas] Int Max Planck Res Sch Translat Psychiat IMPRS TP, Munich, Germany.
   [Hagenberg, Jonas; Knauer-Arloth, Janine] Helmholtz Zentrum Munich, Inst Comp Biol, Neuherberg, Germany.
   [Czisch, Michael] Max Planck Inst Psychiat, Munich, Germany.
   [Binder, Elisabeth B.; Kroemer, Nils B.] German Ctr Mental Hlth, Tubingen, Germany.
   [Kroemer, Nils B.] Univ Tubingen, Dept Psychiat & Psychotherapy, Tubingen Ctr Mental Hlth TuCMH, Tubingen, Germany.
C3 University of Bonn; Max Planck Society; Helmholtz Association;
   Helmholtz-Center Munich - German Research Center for Environmental
   Health; Max Planck Society; Eberhard Karls University of Tubingen
RP Kühnel, A (corresponding author), Univ Bonn, Sect Med Psychol, Dept Psychiat & Psychotherapy, Fac Med, Bonn, Germany.; Kühnel, A; Binder, EB (corresponding author), Max Planck Inst Psychiat, Dept Translat Res Psychiat, Munich, Germany.; Kühnel, A (corresponding author), Int Max Planck Res Sch Translat Psychiat IMPRS TP, Munich, Germany.; Binder, EB (corresponding author), German Ctr Mental Hlth, Tubingen, Germany.
EM akuehnel@uni-bonn.de; binder@psych.mpg.de
RI Kroemer, Nils/H-8309-2019; Kuehnel, Anne/NBX-3544-2025
OI Kuhnel, Anne/0000-0003-3066-3801; Knauer-Arloth,
   Janine/0000-0003-3825-4279; Hagenberg, Jonas/0000-0002-1849-1106
FU Deutsche Forschungsgemeinschaft (DFG) [KR 4555/7-1, KR 4555/9-1, IRTG
   2804]; Brain Behaviour Research Foundation (NARSAD Young Investigator
   Grant) [28063]
FX We thank Anna Hetzel and Ines Eidner for their help with data
   acquisition, Manfred Uhr and the team of the Max Planck Institute of
   Psychiatry Biobank for sample processing. N.B.K. received support from
   the Deutsche Forschungsgemeinschaft (DFG) grants KR 4555/7-1, KR
   4555/9-1, and IRTG 2804. V.I.S. has received income from consultations
   and advisory services for Roche. J.K.-A. was supported by the Brain
   Behaviour Research Foundation (NARSAD Young Investigator Grant, #28063).
CR Adam TC, 2007, PHYSIOL BEHAV, V91, P449, DOI 10.1016/j.physbeh.2007.04.011
   Albert K, 2015, PSYCHONEUROENDOCRINO, V59, P14, DOI 10.1016/j.psyneuen.2015.04.022
   Aruldass AR, 2021, BRAIN BEHAV IMMUN, V98, P299, DOI 10.1016/j.bbi.2021.08.226
   Ashburner J, 2007, NEUROIMAGE, V38, P95, DOI 10.1016/j.neuroimage.2007.07.007
   Barrett LF, 2015, NAT REV NEUROSCI, V16, P419, DOI 10.1038/nrn3950
   Beck AT, 1996, San Antonio, DOI 10.1037/t00742-000
   Behzadi Y, 2007, NEUROIMAGE, V37, P90, DOI 10.1016/j.neuroimage.2007.04.042
   Benson S, 2009, PSYCHONEUROENDOCRINO, V34, P181, DOI 10.1016/j.psyneuen.2008.08.019
   Bini J, 2022, NEUROIMAGE-CLIN, V36, DOI 10.1016/j.nicl.2022.103202
   Brückl TM, 2020, BMC PSYCHIATRY, V20, DOI 10.1186/s12888-020-02541-z
   Burch AE, 2014, INT J PSYCHOPHYSIOL, V94, P1, DOI 10.1016/j.ijpsycho.2014.07.002
   Buzgoova K, 2020, STRESS, V23, P248, DOI 10.1080/10253890.2019.1660872
   Cartier A, 2009, AM J CLIN NUTR, V89, P1307, DOI 10.3945/ajcn.2008.27030
   Caslin HL, 2016, PSYCHOPHYSIOLOGY, V53, P151, DOI 10.1111/psyp.12568
   Champaneri S, 2013, OBESITY, V21, pE56, DOI 10.1002/oby.20047
   Chan KL, 2019, PHYSIOLOGY, V34, P123, DOI 10.1152/physiol.00047.2018
   Chen XJ, 2017, PSYCHONEUROENDOCRINO, V78, P168, DOI 10.1016/j.psyneuen.2017.01.035
   Chiappelli J, 2016, PSYCHONEUROENDOCRINO, V63, P86, DOI 10.1016/j.psyneuen.2015.09.010
   Childs E, 2010, PSYCHOPHYSIOLOGY, V47, P550, DOI 10.1111/j.1469-8986.2009.00961.x
   Clark TD, 2022, PHYSIOL BEHAV, V247, DOI 10.1016/j.physbeh.2022.113713
   Cohen JE, 2023, PSYCHIAT RES-NEUROIM, V332, DOI 10.1016/j.pscychresns.2023.111646
   Craig AD, 2009, NAT REV NEUROSCI, V10, P59, DOI 10.1038/nrn2555
   Cunningham-Bussel AC, 2009, PSYCHONEUROENDOCRINO, V34, P694, DOI 10.1016/j.psyneuen.2008.11.011
   de Wit L, 2010, PSYCHIAT RES, V178, P230, DOI 10.1016/j.psychres.2009.04.015
   DeVille DC, 2018, BIOL PSYCHIAT-COGN N, V3, P546, DOI 10.1016/j.bpsc.2018.03.010
   Dockray S, 2009, J ADOLESCENT HEALTH, V45, P344, DOI 10.1016/j.jadohealth.2009.06.014
   Edwards KM, 2010, BRAIN BEHAV IMMUN, V24, P1202, DOI 10.1016/j.bbi.2010.03.011
   Eisenberger NI, 2007, NEUROIMAGE, V35, P1601, DOI 10.1016/j.neuroimage.2007.01.038
   Ekhtiari H, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-36699-0
   Elbau IG, 2018, P NATL ACAD SCI USA, V115, pE10206, DOI 10.1073/pnas.1804340115
   Farb NAS, 2013, CEREB CORTEX, V23, P114, DOI 10.1093/cercor/bhr385
   Farruggia MC, 2020, PHYSIOL BEHAV, V222, DOI 10.1016/j.physbeh.2020.112940
   Finn ES, 2015, NAT NEUROSCI, V18, P1664, DOI 10.1038/nn.4135
   Garawi F, 2014, EUR J CLIN NUTR, V68, P1101, DOI 10.1038/ejcn.2014.86
   Goldfarb EV, 2019, NEUROBIOL STRESS, V11, DOI 10.1016/j.ynstr.2019.100177
   Grady CL, 2021, HUM BRAIN MAPP, V42, P204, DOI 10.1002/hbm.25217
   GRUNBERG NE, 1992, HEALTH PSYCHOL, V11, P97, DOI 10.1037/0278-6133.11.2.97
   Harrison NA, 2009, BIOL PSYCHIAT, V66, P415, DOI 10.1016/j.biopsych.2009.03.007
   Hedley AA, 2004, JAMA-J AM MED ASSOC, V291, P2847, DOI 10.1001/jama.291.23.2847
   Herbison CE, 2016, STRESS, V19, P139, DOI 10.3109/10253890.2016.1146672
   Herhaus B, 2020, TRANSL PSYCHIAT, V10, DOI 10.1038/s41398-020-0729-6
   Herhaus B, 2018, OBESITY FACTS, V11, P491, DOI 10.1159/000493533
   Herman JP, 2005, PROG NEURO-PSYCHOPH, V29, P1201, DOI 10.1016/j.pnpbp.2005.08.006
   Het S, 2007, BEHAV NEUROSCI, V121, P11, DOI 10.1037/0735-7044.121.1.11
   Holmes MV, 2014, AM J HUM GENET, V94, P198, DOI 10.1016/j.ajhg.2013.12.014
   Iliodromiti S, 2018, EUR HEART J, V39, P1514, DOI 10.1093/eurheartj/ehy057
   Ising M, 2008, EUR J NEUROSCI, V28, P389, DOI 10.1111/j.1460-9568.2008.06332.x
   Jackson SE, 2017, OBESITY, V25, P539, DOI 10.1002/oby.21733
   Janke W., 1978, Die Eigenschaftsworterliste: EWL; eine mehrdimensionale Methode zur Beschreibung von Aspekten des Befindens
   Janke W., 1994, Befindlichkeitsskalierung durch Kategorien und Eigenschaftsworter: BSKE (EWL) nach Janke, Debus, Erdmann und Huppe. Test und Handanweisung
   Jollans L, 2019, NEUROIMAGE, V199, P351, DOI 10.1016/j.neuroimage.2019.05.082
   Jones A, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039143
   Kajantie E, 2006, PSYCHONEUROENDOCRINO, V31, P151, DOI 10.1016/j.psyneuen.2005.07.002
   Kappelmann N, 2021, JAMA PSYCHIAT, V78, P161, DOI 10.1001/jamapsychiatry.2020.3436
   Karczewski J, 2018, EUR CYTOKINE NETW, V29, P83, DOI 10.1684/ecn.2018.0415
   Kessler RC, 2003, J AFFECT DISORDERS, V74, P5, DOI 10.1016/S0165-0327(02)00426-3
   Khan SS, 2018, JAMA CARDIOL, V3, P280, DOI 10.1001/jamacardio.2018.0022
   Kirschbaum C, 1999, PSYCHOSOM MED, V61, P154, DOI 10.1097/00006842-199903000-00006
   Klein SL, 2016, NAT REV IMMUNOL, V16, P626, DOI 10.1038/nri.2016.90
   Kogler L, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-17485-w
   Kopf-Beck J, 2020, BMC PSYCHIATRY, V20, DOI 10.1186/s12888-020-02880-x
   Kroemer NB, 2016, NEUROIMAGE, V128, P273, DOI 10.1016/j.neuroimage.2015.12.031
   Kuehn E, 2016, BRAIN STRUCT FUNCT, V221, P1555, DOI 10.1007/s00429-015-0989-8
   Kühnel A, 2022, BIOL PSYCHIAT, V92, P158, DOI 10.1016/j.biopsych.2022.01.008
   Kühnel A, 2020, HUM BRAIN MAPP, V41, P4010, DOI 10.1002/hbm.25106
   Kuhn L, 2023, CEREB CORTEX, V33, P583, DOI 10.1093/cercor/bhac086
   Kuhn L, 2021, J NEURAL TRANSM, V128, P1347, DOI 10.1007/s00702-021-02390-4
   Kunz-Ebrecht SR, 2003, BRAIN BEHAV IMMUN, V17, P373, DOI 10.1016/S0889-1591(03)00029-1
   Lee MR, 2014, NEUROPSYCHOLOGIA, V53, P257, DOI 10.1016/j.neuropsychologia.2013.11.022
   Livneh Y, 2020, NEURON, V105, P1094, DOI 10.1016/j.neuron.2019.12.027
   Macht M, 2007, APPETITE, V49, P667, DOI 10.1016/j.appet.2007.05.004
   Mathieu P, 2010, CLIN PHARMACOL THER, V87, P407, DOI 10.1038/clpt.2009.311
   McEwen BS, 2010, ANN NY ACAD SCI, V1186, P190, DOI 10.1111/j.1749-6632.2009.05331.x
   McEwen BS, 2004, ANN NY ACAD SCI, V1032, P1, DOI 10.1196/annals.1314.001
   McInnis CM, 2014, BRAIN BEHAV IMMUN, V42, P33, DOI 10.1016/j.bbi.2014.07.018
   McLaren DG, 2012, NEUROIMAGE, V61, P1277, DOI 10.1016/j.neuroimage.2012.03.068
   McLean CP, 2011, J PSYCHIATR RES, V45, P1027, DOI 10.1016/j.jpsychires.2011.03.006
   Mejia AF, 2018, NEUROIMAGE, V172, P478, DOI 10.1016/j.neuroimage.2018.01.029
   Meule A, 2018, APPETITE, V120, P442, DOI 10.1016/j.appet.2017.10.003
   Miedl SF, 2016, NEUROIMAGE, V132, P138, DOI 10.1016/j.neuroimage.2016.02.027
   Moller DE, 2005, ANNU REV MED, V56, P45, DOI 10.1146/annurev.med.56.082103.104751
   Monteiro R, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/289645
   Narayan M, 2016, FRONT NEUROSCI-SWITZ, V10, DOI 10.3389/fnins.2016.00108
   Newman E, 2007, PSYCHONEUROENDOCRINO, V32, P125, DOI 10.1016/j.psyneuen.2006.11.006
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Noack H, 2019, J NEURAL TRANSM, V126, P1187, DOI 10.1007/s00702-018-01965-y
   Onat A, 2016, EXPERT REV CARDIOVAS, V14, P513, DOI 10.1586/14779072.2016.1150782
   Ordaz S, 2012, PSYCHONEUROENDOCRINO, V37, P1135, DOI 10.1016/j.psyneuen.2012.01.002
   Park BY, 2020, HUM BRAIN MAPP, V41, P4912, DOI 10.1002/hbm.25167
   Pasquali R, 2008, INT J OBESITY, V32, P1764, DOI 10.1038/ijo.2008.129
   Pervaiz U, 2020, NEUROIMAGE, V211, DOI 10.1016/j.neuroimage.2020.116604
   Power JD, 2014, NEUROIMAGE, V84, P320, DOI 10.1016/j.neuroimage.2013.08.048
   Preiss K, 2013, OBES REV, V14, P906, DOI 10.1111/obr.12052
   Pruessner JC, 2008, BIOL PSYCHIAT, V63, P234, DOI 10.1016/j.biopsych.2007.04.041
   R Core Team, 2019, R LANG ENV STAT COMP
   Rechlin RK, 2022, NAT COMMUN, V13, DOI 10.1038/s41467-022-29903-3
   Rodriguez ACI, 2015, PSYCHONEUROENDOCRINO, V62, P301, DOI 10.1016/j.psyneuen.2015.08.014
   Rodríguez-Liñares L, 2008, ACTAS DE LA III CONFERENCIA IBERICA DE SISTEMAS Y TECNOLOGIAS DE LA INFORMACION, VOL 1, P565
   Rohleder N, 2019, PSYCHONEUROENDOCRINO, V105, P164, DOI 10.1016/j.psyneuen.2019.02.021
   Sandner M, 2020, PSYCHONEUROENDOCRINO, V118, DOI 10.1016/j.psyneuen.2020.104660
   Schmalenberger KM, 2021, PSYCHONEUROENDOCRINO, V123, DOI 10.1016/j.psyneuen.2020.104895
   Schorr M, 2015, J CLIN ENDOCR METAB, V100, P3313, DOI 10.1210/JC.2015-2078
   Shen X, 2013, NEUROIMAGE, V82, P403, DOI 10.1016/j.neuroimage.2013.05.081
   Shenhav A, 2013, NEURON, V79, P217, DOI 10.1016/j.neuron.2013.07.007
   Shi H, 2009, PHYSIOL BEHAV, V97, P199, DOI 10.1016/j.physbeh.2009.02.017
   Shilton AL, 2017, FRONT PSYCHOL, V8, DOI 10.3389/fpsyg.2017.00567
   Srivastava P, 2021, EAT WEIGHT DISORD-ST, V26, P2413, DOI 10.1007/s40519-020-01082-4
   Suridjan I, 2012, J PSYCHIATR RES, V46, P890, DOI 10.1016/j.jpsychires.2012.03.009
   Syan SK, 2021, NEUROSCI BIOBEHAV R, V131, P270, DOI 10.1016/j.neubiorev.2021.08.019
   Symonds CS, 2012, EUR NEUROPSYCHOPHARM, V22, P867, DOI 10.1016/j.euroneuro.2012.03.008
   Therrien F, 2010, BIOL PSYCHOL, V84, P325, DOI 10.1016/j.biopsycho.2010.03.013
   Thorand B, 2006, ATHEROSCLEROSIS, V184, P216, DOI 10.1016/j.atherosclerosis.2005.04.011
   Tramunt B, 2020, DIABETOLOGIA, V63, P453, DOI 10.1007/s00125-019-05040-3
   Vaisvaser S, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00313
   van der Valk ES, 2018, CURR OBES REP, V7, P193, DOI 10.1007/s13679-018-0306-y
   van Oort J, 2017, NEUROSCI BIOBEHAV R, V83, P281, DOI 10.1016/j.neubiorev.2017.10.015
   Varghese M, 2017, ADV EXP MED BIOL, V1043, P65, DOI 10.1007/978-3-319-70178-3_5
   Veer IM, 2011, NEUROIMAGE, V57, P1534, DOI 10.1016/j.neuroimage.2011.05.074
   Vest AN, 2018, PHYSIOL MEAS, V39, DOI 10.1088/1361-6579/aae021
   Vila J, 1997, IEEE ENG MED BIOL, V16, P119, DOI 10.1109/51.620503
   von Dawans B, 2021, PSYCHONEUROENDOCRINO, V126, DOI 10.1016/j.psyneuen.2020.105062
   Winham SJ, 2021, NAT METAB, V3, P1586, DOI 10.1038/s42255-021-00503-7
   Wisse BE, 2004, J AM SOC NEPHROL, V15, P2792, DOI 10.1097/01.ASN.0000141966.69934.21
   Wittchen H. U., 1995, Munchener Composite International Diagnostic Interview (M-CIDI)
   Wust Stefan, 2000, Noise Health, V2, P79
   Yudkin JS, 2007, HORM METAB RES, V39, P707, DOI 10.1055/s-2007-985898
   Zellner DA, 2006, PHYSIOL BEHAV, V87, P789, DOI 10.1016/j.physbeh.2006.01.014
   Zschucke E, 2015, PSYCHONEUROENDOCRINO, V51, P414, DOI 10.1016/j.psyneuen.2014.10.019
NR 128
TC 4
Z9 4
U1 2
U2 9
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
EI 2399-3642
J9 COMMUN BIOL
JI Commun. Biol.
PD OCT 11
PY 2023
VL 6
IS 1
AR 1031
DI 10.1038/s42003-023-05396-8
PG 15
WC Biology; Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Science & Technology - Other
   Topics
GA AB2O6
UT WOS:001115932000001
PM 37821711
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Marcovecchio, ML
   Chiarelli, F
AF Marcovecchio, M. Loredana
   Chiarelli, Francesco
TI ENDOCRINOLOGY The Effects of Acute and Chronic Stress on Diabetes
   Control
SO SCIENCE SIGNALING
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIALS; IMPROVE GLYCEMIC CONTROL; PSYCHOLOGICAL
   INTERVENTIONS; METAANALYSIS
AB Stress is an important contributor to pathological conditions in humans. Hormonal changes that occur during acute and chronic stress situations can affect glucose homeostasis in both healthy people and in those with diabetes. Several studies have reported a negative effect of acute stress on maintenance of blood glucose concentrations in patients with type 1 and type 2 diabetes. The effect of stress on glycemic control in people with diabetes may be related to a direct effect of stress hormones on blood glucose levels and an indirect effect of stress on patient behaviors related to diabetes treatment and monitoring and meal and exercise plans. In contrast, there is no clear evidence that stressful life events promote the development of diabetes in children or in adults. Stress hyperglycemia, the development of hyperglycemia during acute illness, represents another interesting connection between the stress system and glucose homeostasis. A large body of evidence supports an association between stress hyperglycemia and increased morbidity and mortality in critically ill patients. Interestingly, there is some evidence supporting a beneficial effect of insulin in reducing morbidity and mortality in patients admitted to intensive care units. Finally, stress can influence the development of type 2 diabetes indirectly by promoting obesity and metabolic syndrome.
C1 [Marcovecchio, M. Loredana; Chiarelli, Francesco] Univ G dAnnunzio, Dept Paediat, I-66013 Chieti, Italy.
C3 G d'Annunzio University of Chieti-Pescara
RP Chiarelli, F (corresponding author), Univ G dAnnunzio, Dept Paediat, I-66013 Chieti, Italy.
EM chiarelli@unich.it
OI Maria Loredana, Marcovecchio/0000-0002-4415-316X
CR Cosgrove M, 2004, OCCUP MED-OXFORD, V54, P250, DOI 10.1093/occmed/kqh047
   Dungan KM, 2009, LANCET, V373, P1798, DOI 10.1016/S0140-6736(09)60553-5
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Ellahham S, 2010, VASC HEALTH RISK MAN, V6, P1089, DOI 10.2147/VHRM.S14203
   Faulenbach M, 2012, DIABETIC MED, V29, P128, DOI 10.1111/j.1464-5491.2011.03431.x
   GELFAND RA, 1984, J CLIN INVEST, V74, P2238, DOI 10.1172/JCI111650
   Ismail K, 2004, LANCET, V363, P1589, DOI 10.1016/S0140-6736(04)16202-8
   Kyrou I, 2009, CURR OPIN PHARMACOL, V9, P787, DOI 10.1016/j.coph.2009.08.007
   Lloyd CE, 1999, DIABETES CARE, V22, P1278, DOI 10.2337/diacare.22.8.1278
   Mazziotti G, 2011, TRENDS ENDOCRIN MET, V22, P499, DOI 10.1016/j.tem.2011.09.001
   Radahmadi Maryam, 2006, Pathophysiology, V13, P51, DOI 10.1016/j.pathophys.2005.07.001
   SURWIT RS, 1993, PSYCHOSOM MED, V55, P380, DOI 10.1097/00006842-199307000-00005
   Van den Berghe G, 2001, NEW ENGL J MED, V345, P1359, DOI 10.1056/NEJMoa011300
   Viner R, 1996, ARCH DIS CHILD, V74, P418, DOI 10.1136/adc.74.5.418
   Wiesli P, 2005, DIABETES CARE, V28, P1910, DOI 10.2337/diacare.28.8.1910
   WING RR, 1985, PSYCHOSOM MED, V47, P558, DOI 10.1097/00006842-198511000-00005
   Winkley K, 2006, BMJ-BRIT MED J, V333, P65, DOI 10.1136/bmj.38874.652569.55
NR 17
TC 52
Z9 60
U1 0
U2 39
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 1945-0877
EI 1937-9145
J9 SCI SIGNAL
JI Sci. Signal.
PD OCT 23
PY 2012
VL 5
IS 247
AR pt10
DI 10.1126/scisignal.2003508
PG 3
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 028VH
UT WOS:000310451800002
PM 23092890
DA 2025-06-11
ER

PT J
AU Reynolds, RM
AF Reynolds, Rebecca M.
TI Glucocorticoid excess and the developmental origin of disease: Two
   decades of testing the hypothesis-2012 Curt Richter Award Winner
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE Glucocorticoids; Hypothalami- pituitary-adrenal axis; Birthweight;
   Programming; Metabolic syndrome; Cognitive decline
ID CORTICOTROPIN-RELEASING HORMONE; PITUITARY-ADRENAL AXIS;
   LOW-BIRTH-WEIGHT; PLASMA-CORTISOL CONCENTRATIONS; CARDIOVASCULAR
   RISK-FACTORS; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-2; MESSENGER-RNA
   EXPRESSION; RECEPTOR GENE-EXPRESSION; CORONARY-ARTERY-DISEASE; HEALTHY
   ELDERLY-MEN
AB Low birthweight, a marker of an adverse in utero environment, is associated with cardiometabolic disease and brain disorders in adulthood. The adaptive changes made by the fetus in response to the intra-uterine environment result in permanent changes in physiology, structure and metabolism, a phenomenon termed early life programming. One of the key hypotheses to explain programming, namely over exposure of the developing fetus to glucocorticoids, was proposed nearly two decades ago, following the observation that the fetus was protected from high glucocorticoid levels in the mother by the actions of the placental barrier enzyme, 11 beta-hydroxysteroid dehydrogenase, which converts active glucocorticoids into inactive products. Numerous mechanistic studies in animal models have been carried out to test this hypothesis using manipulations to increase maternal glucocorticoids. Overall, these have resulted in offspring of lower birthweight, with an activated hypothalamic-pituitary-adrenal (HPA) axis and an adverse metabolic profile and behavioural phenotype in adulthood.
   Altered glucocorticoid activity or action is a good candidate mechanism in humans to link low birthweight with cardiometabolic and brain disorders. We have carried out detailed studies in men and women showing that high levels of endogenous glucocorticoids, or treatment with exogenous glucocorticoids, is associated with an adverse metabolic profile, increased cardiovascular disease and altered mood and cognitive decline. Our laboratory carried out the first translational studies in humans to test the glucocorticoid hypothesis, firstly demonstrating in studies of adult men and women, that low birthweight was associated with high fasting cortisol levels. We went on to dissect the mechanisms underlying the high fasting cortisol, demonstrating activation of the HPA axis, with increased cortisol responses to stimulation with exogenous adrenocorticotrophin hormone, lack of habituation to the stress of venepuncture, and increased cortisol responses to psychosocial stress. We have developed new dynamic tests to dissect the mechanisms regulating HPA axis central negative feedback sensitivity in humans, and demonstrated that this may be altered in obesity, one component of the metabolic syndrome.
   There are now studies in humans demonstrating that high circulating levels of maternal cortisol during pregnancy correlate negatively with birthweight, suggesting that excess glucocorticoids can by-pass the placental barrier. Deficiencies in the barrier enzyme, potentially increasing fetal glucocorticoid exposure, can also arise in association with maternal stress, malnutrition and disease, and can be inhibited by consumption of liquorice, which contains glycyrrhizin, an HSD inhibitor. Importantly, studies in humans have now demonstrated that high maternal cortisol in pregnancy and/or inhibition of HSD2 are associated with programmed outcomes in childhood including higher blood pressure, behavioural disorders as well as altered brain structure. We are investigating this further, using novel magnetic resonance imaging techniques to study the developing fetal brain in utero.
   The translational studies in support of the glucocorticoid hypothesis, and demonstrating that glucocorticoids are both mediators and targets of programming, are exciting and raise the question of whether this information can be used to identify those individuals most at risk of later life disease. In a recent study we showed that alterations in DNA rnethylation at genes important in regulating cortisol levels, tissue glucocorticoid action, blood pressure and fetal growth, are present in adulthood in association with both early life parameters and cardiometabolic risk factors. These preliminary data add to the limited literature in humans indicating a persisting epigenetic link between early life events and subsequent disease risk. Such findings open novel avenues for further exploration of the contribution of glucocorticoids to later life disease. (C) 2012 Elsevier Ltd. All rights reserved.
C1 Univ BHF Ctr Cardiovasc Sci, Endocrinol Unit, Queens Med Res Inst, Edinburgh EH16 4TJ, Midlothian, Scotland.
C3 University of Edinburgh
RP Reynolds, RM (corresponding author), Univ BHF Ctr Cardiovasc Sci, Endocrinol Unit, Queens Med Res Inst, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, Scotland.
EM R.Reynolds@ed.ac.uk
RI Reynolds, Rebecca M/C-3044-2008
OI Reynolds, Rebecca M/0000-0001-6226-8270
FU Wellcome Trust; Medical Research Council; British Heart Foundation;
   Chief Scientist Office, Scotland
FX The studies reported in this manuscript were supported in part by grants
   from the Wellcome Trust, the Medical Research Council, the British Heart
   Foundation and the Chief Scientist Office, Scotland.
CR Alevizaki M, 2007, METABOLISM, V56, P222, DOI 10.1016/j.metabol.2006.09.017
   Andrews RC, 2002, J CLIN ENDOCR METAB, V87, P5587, DOI 10.1210/jc.2002-020048
   Bamberger CM, 1996, ENDOCR REV, V17, P245, DOI 10.1210/er.17.3.245
   BARKER DJP, 1995, BRIT MED J, V311, P171, DOI 10.1136/bmj.311.6998.171
   BARKER DJP, 1993, LANCET, V341, P938, DOI 10.1016/0140-6736(93)91224-A
   BENEDIKTSSON R, 1993, LANCET, V341, P339, DOI 10.1016/0140-6736(93)90138-7
   Benediktsson R, 1997, CLIN ENDOCRINOL, V46, P161, DOI 10.1046/j.1365-2265.1997.1230939.x
   Bergman K, 2010, BIOL PSYCHIAT, V67, P1026, DOI 10.1016/j.biopsych.2010.01.002
   BERNAL AL, 1980, J STEROID BIOCHEM, V13, P1081, DOI 10.1016/0022-4731(80)90140-5
   Bolten MI, 2011, ARCH WOMEN MENT HLTH, V14, P33, DOI 10.1007/s00737-010-0183-1
   Brown RW, 1996, ENDOCRINOLOGY, V137, P794, DOI 10.1210/en.137.2.794
   Broyd SJ, 2009, NEUROSCI BIOBEHAV R, V33, P279, DOI 10.1016/j.neubiorev.2008.09.002
   Buss C, 2012, P NATL ACAD SCI USA, V109, pE1312, DOI 10.1073/pnas.1201295109
   CAMPBELL EA, 1987, J CLIN ENDOCR METAB, V64, P1054, DOI 10.1210/jcem-64-5-1054
   COLE TJ, 1995, STEROIDS, V60, P93, DOI 10.1016/0039-128X(94)00009-2
   Cottrell EC, 2012, FASEB J, V26, P1866, DOI 10.1096/fj.12-203489
   Cottrell EC, 2009, FRONT BEHAV NEUROSCI, V3, DOI 10.3389/neuro.08.019.2009
   Dalziel SR, 2005, LANCET, V365, P1856, DOI 10.1016/S0140-6736(05)66617-2
   Dave-Sharma S, 1998, J CLIN ENDOCR METAB, V83, P2244, DOI 10.1210/jc.83.7.2244
   Davis EP, 2011, J CHILD PSYCHOL PSYC, V52, P119, DOI 10.1111/j.1469-7610.2010.02314.x
   de Rooij SR, 2006, EUR J ENDOCRINOL, V155, P153, DOI 10.1530/eje.1.02193
   Diego MA, 2006, PSYCHOSOM MED, V68, P747, DOI 10.1097/01.psy.0000238212.21598.7b
   Doyle LW, 2000, CLIN SCI, V98, P137, DOI 10.1042/CS19990211
   Drake AJ, 2012, CLIN ENDOCRINOL, V77, P808, DOI 10.1111/j.1365-2265.2012.04453.x
   EDWARDS CRW, 1993, LANCET, V341, P355, DOI 10.1016/0140-6736(93)90148-A
   Entringer S, 2011, PSYCHOSOM MED, V73, P469, DOI 10.1097/PSY.0b013e31821fbf9a
   Entringer S, 2010, CURR OPIN ENDOCRINOL, V17, P507, DOI 10.1097/MED.0b013e3283405921
   Fall CHD, 2002, J CLIN ENDOCR METAB, V87, P2001, DOI 10.1210/jc.87.5.2001
   Filiberto AC, 2011, EPIGENETICS-US, V6, P566, DOI 10.4161/epi.6.5.15236
   French NP, 1999, AM J OBSTET GYNECOL, V180, P114, DOI 10.1016/S0002-9378(99)70160-2
   Gardner DS, 1997, HYPERTENSION, V30, P1525, DOI 10.1161/01.HYP.30.6.1525
   Geoffroy M.C., 2011, PSYCHOL MED, V1, P1
   Gitau R, 2004, ARCH DIS CHILD-FETAL, V89, pF29, DOI 10.1136/fn.89.1.F29
   Gitau R, 2001, J CLIN ENDOCR METAB, V86, P104, DOI 10.1210/jc.86.1.104
   Gitau R, 1998, LANCET, V352, P707, DOI 10.1016/S0140-6736(05)60824-0
   Goedhart G, 2010, PSYCHONEUROENDOCRINO, V35, P644, DOI 10.1016/j.psyneuen.2009.10.003
   GOLAND RS, 1994, AM J OBSTET GYNECOL, V171, P1287, DOI 10.1016/0002-9378(94)90149-X
   Haller J, 2008, FRONT NEUROENDOCRIN, V29, P273, DOI 10.1016/j.yfrne.2007.10.004
   Harville E, 2010, OBSTET GYNECOL SURV, V65, P713, DOI 10.1097/OGX.0b013e31820eddbe
   Harville EW, 2009, J WOMENS HEALTH, V18, P1425, DOI 10.1089/jwh.2008.1102
   Herrmann TS, 2001, AM J OBSTET GYNECOL, V185, P403, DOI 10.1067/mob.2001.115863
   Hughes KA, 2010, J CLIN ENDOCR METAB, V95, P4696, DOI 10.1210/jc.2010-0384
   Huh SY, 2008, BMC MED, V6, DOI 10.1186/1741-7015-6-25
   Jung C, 2011, J CLIN ENDOCR METAB, V96, P1533, DOI 10.1210/jc.2010-2395
   Kajantie E, 2004, CLIN ENDOCRINOL, V60, P201, DOI 10.1046/j.1365-2265.2003.01965.x
   Kajantie E, 2003, EUR J ENDOCRINOL, V149, P569, DOI 10.1530/eje.0.1490569
   Kang HJ, 2011, NATURE, V478, P483, DOI 10.1038/nature10523
   Kay HH, 2000, J SOC GYNECOL INVEST, V7, P269, DOI 10.1016/S1071-5576(00)00075-7
   LangleyEvans SC, 1997, J HYPERTENS, V15, P537, DOI 10.1097/00004872-199715050-00010
   LangleyEvans SC, 1996, PLACENTA, V17, P169, DOI 10.1016/S0143-4004(96)80010-5
   Levitt NS, 1996, NEUROENDOCRINOLOGY, V64, P412, DOI 10.1159/000127146
   Levitt NS, 2000, J CLIN ENDOCR METAB, V85, P4611, DOI 10.1210/jc.85.12.4611
   Lindsay JR, 2005, ENDOCR REV, V26, P775, DOI 10.1210/er.2004-0025
   MacLullich AMJ, 2005, PSYCHONEUROENDOCRINO, V30, P505, DOI 10.1016/j.psyneuen.2004.12.005
   Mangos GJ, 2000, AM J HYPERTENS, V13, P1155, DOI 10.1016/S0895-7061(00)01201-2
   Marsit CJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033794
   Mattsson C, 2009, J CLIN ENDOCR METAB, V94, P1347, DOI 10.1210/jc.2008-2054
   McEwen BS, 1999, FRONT NEUROENDOCRIN, V20, P49, DOI 10.1006/frne.1998.0173
   McTernan CL, 2001, J CLIN ENDOCR METAB, V86, P4979, DOI 10.1210/jc.86.10.4979
   Mesiano S, 1997, ENDOCR REV, V18, P378, DOI 10.1210/er.18.3.378
   MURPHY BEP, 1974, AM J OBSTET GYNECOL, V118, P538, DOI 10.1016/S0002-9378(16)33697-3
   Orth D.N., 1992, ADRENAL CORTEX WILLI, P489
   Ozanne SE, 2007, NAT CLIN PRACT ENDOC, V3, P539, DOI 10.1038/ncpendmet0531
   Philip RCM, 2012, NEUROSCI BIOBEHAV R, V36, P901, DOI 10.1016/j.neubiorev.2011.10.008
   Phillips DIW, 1998, J CLIN ENDOCR METAB, V83, P757, DOI 10.1210/jc.83.3.757
   Phillips DIW, 2000, HYPERTENSION, V35, P1301, DOI 10.1161/01.HYP.35.6.1301
   Räikkönen K, 2010, PSYCHONEUROENDOCRINO, V35, P1587, DOI 10.1016/j.psyneuen.2010.04.010
   Räikkönen K, 2009, AM J EPIDEMIOL, V170, P1137, DOI 10.1093/aje/kwp272
   Ravelli ACJ, 1998, LANCET, V351, P173, DOI 10.1016/S0140-6736(97)07244-9
   Reynolds RM, 2009, QJM-INT J MED, V102, P469, DOI 10.1093/qjmed/hcp057
   Reynolds RM, 2007, J CLIN ENDOCR METAB, V92, P2208, DOI 10.1210/jc.2007-0071
   Reynolds RM, 2012, EUR J ENDOCRINOL, V166, P861, DOI 10.1530/EJE-12-0041
   Reynolds RM, 2010, DIABETES CARE, V33, P714, DOI 10.2337/dc09-1796
   Reynolds RM, 2010, J CLIN ENDOCR METAB, V95, P1602, DOI 10.1210/jc.2009-2112
   Reynolds RM, 2001, J CLIN ENDOCR METAB, V86, P1149, DOI 10.1210/jc.86.3.1149
   Reynolds RM, 2001, J CLIN ENDOCR METAB, V86, P245, DOI 10.1210/jc.86.1.245
   Reynolds RM, 2002, JAMA-J AM MED ASSOC, V287, P2505, DOI 10.1001/jama.287.19.2505
   Reynolds RM, 2003, METABOLISM, V52, P524, DOI 10.1053/meta.2003.50090
   Reynolds RM, 2005, EUR J ENDOCRINOL, V152, P249, DOI 10.1530/eje.1.01846
   Reynolds RM, 2003, DIABETES OBES METAB, V5, P5, DOI 10.1046/j.1463-1326.2003.00221.x
   Roberts D, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004454.pub3
   Roseboom T, 2006, EARLY HUM DEV, V82, P485, DOI 10.1016/j.earlhumdev.2006.07.001
   Rosmond R, 1998, J CLIN ENDOCR METAB, V83, P1853, DOI 10.1210/jc.83.6.1853
   Sandeep TC, 2004, P NATL ACAD SCI USA, V101, P6734, DOI 10.1073/pnas.0306996101
   Sandman CA, 2006, PEPTIDES, V27, P1457, DOI 10.1016/j.peptides.2005.10.002
   Seckl JR, 2004, EUR J ENDOCRINOL, V151, pU49, DOI 10.1530/eje.0.151u049
   SECKL JR, 1991, BRAIN RES, V561, P332, DOI 10.1016/0006-8993(91)91612-5
   Smith AK, 2011, CLIN ENDOCRINOL, V75, P90, DOI 10.1111/j.1365-2265.2011.03998.x
   SMITH ID, 1974, J OBSTET GYN BR COMM, V81, P11
   STEWART PM, 1995, J CLIN ENDOCR METAB, V80, P885, DOI 10.1210/jc.80.3.885
   Strandberg TE, 2002, AM J EPIDEMIOL, V156, P803, DOI 10.1093/aje/kwf130
   Strandberg TE, 2001, AM J EPIDEMIOL, V153, P1085, DOI 10.1093/aje/153.11.1085
   Van Dijk AE, 2012, EARLY HUM DEV, V88, P351, DOI 10.1016/j.earlhumdev.2011.09.009
   van Montfoort N, 2005, EUR J ENDOCRINOL, V153, P811, DOI 10.1530/eje.1.02050
   Ward AMV, 2003, CLIN ENDOCRINOL, V58, P500, DOI 10.1046/j.1365-2265.2003.01750.x
   Welberg LAM, 2000, EUR J NEUROSCI, V12, P1047, DOI 10.1046/j.1460-9568.2000.00958.x
   Wüst S, 2005, PSYCHONEUROENDOCRINO, V30, P591, DOI 10.1016/j.psyneuen.2005.01.008
   Yehuda R, 2005, J CLIN ENDOCR METAB, V90, P4115, DOI 10.1210/jc.2005-0550
NR 98
TC 364
Z9 415
U1 0
U2 136
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JAN
PY 2013
VL 38
IS 1
BP 1
EP 11
DI 10.1016/j.psyneuen.2012.08.012
PG 11
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 073RU
UT WOS:000313761000001
PM 22998948
DA 2025-06-11
ER

PT J
AU Bourebaba, N
   Sikora, M
   Qasem, B
   Bourebaba, L
   Marycz, K
AF Bourebaba, Nabila
   Sikora, Mateusz
   Qasem, Badr
   Bourebaba, Lynda
   Marycz, Krzysztof
TI Sex hormone-binding globulin (SHBG) mitigates ER stress and improves
   viability and insulin sensitivity in adipose-derived mesenchymal stem
   cells (ASC) of equine metabolic syndrome (EMS)-affected horses
SO CELL COMMUNICATION AND SIGNALING
LA English
DT Article
DE EMS; ASC; SHBG; ER Stress; Apoptosis; PDIA3; Insulin resistance
ID OXIDATIVE STRESS; DIABETES-MELLITUS; PROTEIN; WOMEN; RESISTANCE;
   KINASES; PATHWAY; RISK
AB BackgroundEquine metabolic syndrome (EMS), which encompasses insulin resistance, low-grade inflammation and predisposition to laminitis is a critical endocrine disorder among the most prevalent conditions affecting horses from different breeds. According to the most recent research, low human sex hormone-binding globulin (SHBG) serum levels correlate with an increased risk of obesity, insulin resistance and diabetes, and may contribute to overall metabolic dysregulations. This study aimed to test whether exogenous SHBG could protect EMS affected adipose-derived stromal stem cells (EqASCEMS) from apoptosis, oxidative stress, ER stress and thus improve insulin sensitivity.MethodsEqASCEMS wells were treated with two different concentrations (50 and 100 nM) of exogenous SHBG, whose biocompatibility was tested after 24, 48 and 72 h of incubation. Several parameters including cell viability, apoptosis, cell cycle, reactive oxygen species levels, ER stress, Pi3K/MAPK activation and insulin transducers expression were analysed.ResultsObtained data demonstrated that exogenous SHBG treatment significantly promoted ASCs cells proliferation, cell cycle and survival with reduced expression of p53 and p21 pro-apoptotic mediators. Furthermore, SHBG alleviated the oxidative stress caused by EMS and reduced the overaccumulation of intracellular ROS, by reducing ROS + cell percentage and regulating gene expression of endogenous antioxidant enzymes (Sod 1, Cat, GPx), SHBG treatment exhibited antioxidant activity by modulating total nitric oxide (NO) levels in EMS cells as well. SHBG treatment dampened the activation of ER stress sensors and effectors in EqASCEMS cells via the upregulation of MiR-7a-5p, the decrease in the expression levels of ATF-6, CHOP and eiF2A and the restoration of PDIA3 chaperone protein levels. As a consequence, SHBG application substantially improved insulin sensitivity through the modulation of Pi3K/Akt/Glut4 insulin signalling cascades.ConclusionOur results suggest that the SHBG is endowed with crucial beneficial effects on ASCs metabolic activities and could serve as a valuable therapeutic target for the development of efficient EMS treatment protocols.1CMnBWH6nCsmkUsG-EU1vwVideo AbstractConclusionOur results suggest that the SHBG is endowed with crucial beneficial effects on ASCs metabolic activities and could serve as a valuable therapeutic target for the development of efficient EMS treatment protocols.1CMnBWH6nCsmkUsG-EU1vwVideo Abstract
C1 [Bourebaba, Nabila; Sikora, Mateusz; Qasem, Badr; Bourebaba, Lynda] Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, Norwida 27B, PL-50375 Wroclaw, Poland.
   [Marycz, Krzysztof] Univ Calif Davis, Dept Med & Epidemiol, Sch Vet Med, Davis, CA 95616 USA.
   [Marycz, Krzysztof] Univ Calif Davis, Vet Inst Regenerat Cures, Sch Vet Med, Dept Vet Med & Epidemiol, Davis, CA 95616 USA.
C3 Wroclaw University of Environmental & Life Sciences; University of
   California System; University of California Davis; University of
   California System; University of California Davis
RP Marycz, K (corresponding author), Univ Calif Davis, Dept Med & Epidemiol, Sch Vet Med, Davis, CA 95616 USA.; Marycz, K (corresponding author), Univ Calif Davis, Vet Inst Regenerat Cures, Sch Vet Med, Dept Vet Med & Epidemiol, Davis, CA 95616 USA.
EM kmmarycz@ucdavis.edu
RI Bourebaba, Nabila/JRY-9553-2023; Marycz, Krzysztof/A-2249-2017; Qasem,
   Badr/AAF-4418-2019; Bourebaba, Lynda/AAX-7613-2020
OI Qasem, Badr/0000-0001-7085-0287
FU Not Applicable.
FX Not Applicable.
CR BIRKELAND KI, 1993, J CLIN ENDOCR METAB, V76, P275, DOI 10.1210/jc.76.2.275
   Bourebaba L, 2021, STEM CELL RES THER, V12, DOI 10.1186/s13287-020-02102-x
   Bourebaba L, 2019, STEM CELL RES THER, V10, DOI 10.1186/s13287-019-1499-z
   Bourebaba L, 2019, J CLIN MED, V8, DOI 10.3390/jcm8122033
   Bourebaba N, 2022, BIOMED PHARMACOTHER, V153, DOI 10.1016/j.biopha.2022.113261
   Burns TA., 2016, EQUINE LAMINITIS, P49, DOI [10.1002/9781119169239.ch18, DOI 10.1002/9781119169239.CH18]
   Calderon-Margalit R, 2010, J CLIN ENDOCR METAB, V95, P4424, DOI 10.1210/jc.2009-2643
   Catalano KJ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0108693
   Chen C, 2010, MINERVA ENDOCRINOL, V35, P271
   Chi XS, 2020, J OBSTET GYNAECOL RE, V46, P2340, DOI 10.1111/jog.14429
   Cignarelli A, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20030759
   Donnelly N, 2013, CELL MOL LIFE SCI, V70, P3493, DOI 10.1007/s00018-012-1252-6
   Enli Y, 2013, GYNECOL ENDOCRINOL, V29, P1036, DOI 10.3109/09513590.2013.829442
   Feng C, 2018, GYNECOL ENDOCRINOL, V34, P567, DOI 10.1080/09513590.2017.1411474
   Foss-Freitas MC, 2018, DIABETOL METAB SYNDR, V10, DOI 10.1186/s13098-017-0301-6
   Frank N, 2014, EQUINE VET J, V46, P103, DOI 10.1111/evj.12169
   Hemmings BA, 2012, CSH PERSPECT BIOL, V4, DOI 10.1101/cshperspect.a011189
   Hurrle S, 2017, BIOMED J, V40, P257, DOI 10.1016/j.bj.2017.06.007
   Kornicka-Garbowska K, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10040755
   Lebeaupin C, 2018, J HEPATOL, V69, P927, DOI 10.1016/j.jhep.2018.06.008
   Lu ZM, 2006, IUBMB LIFE, V58, P621, DOI 10.1080/15216540600957438
   Macut D, 2011, EXP CLIN ENDOCR DIAB, V119, P451, DOI 10.1055/s-0031-1279740
   Marycz K, 2019, STEM CELL REV REP, V15, P842, DOI 10.1007/s12015-019-09913-3
   Marycz K, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19010165
   Marycz K, 2018, RES VET SCI, V118, P115, DOI 10.1016/j.rvsc.2018.01.015
   Marycz K, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/4710326
   Monserrat-Mesquida M, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9030236
   Morgan R, 2015, VET REC, V177, P173, DOI 10.1136/vr.103226
   Mularczyk M, 2022, BIOMOLECULES, V12, DOI 10.3390/biom12081039
   Muller C, 2013, ANTIOXID REDOX SIGN, V18, P731, DOI 10.1089/ars.2012.4577
   Perry JRB, 2010, HUM MOL GENET, V19, P535, DOI 10.1093/hmg/ddp522
   Qu XQ, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21218191
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Rosner W, 1999, J STEROID BIOCHEM, V69, P481, DOI 10.1016/S0960-0760(99)00070-9
   Sikora M, 2021, J CELL MOL MED, V25, P6634, DOI 10.1111/jcmm.16667
   Smieszek A, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11091437
   Sriram S, 2019, STEM CELL RES THER, V10, DOI 10.1186/s13287-019-1240-y
   Sun Y, 2021, FERTIL STERIL, V116, P1641, DOI 10.1016/j.fertnstert.2021.07.1203
   Targonska S, 2020, ACS BIOMATER SCI ENG, V6, P6148, DOI 10.1021/acsbiomaterials.0c00824
   Tobita M, 2015, STEM CELL RES THER, V6, DOI 10.1186/s13287-015-0217-8
   Tsuji Wakako, 2014, World J Stem Cells, V6, P312, DOI 10.4252/wjsc.v6.i3.312
   Turano C, 2011, CELL MOL BIOL LETT, V16, P539, DOI 10.2478/s11658-011-0022-z
   Ullah A, 2016, SAUDI PHARM J, V24, P547, DOI 10.1016/j.jsps.2015.03.013
   Victor P, 2021, EUR J PHARMACOL, V892, DOI 10.1016/j.ejphar.2020.173749
   Vona R, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8267234
   Watson LS, 2022, DIABETES VASC DIS RE, V19, DOI 10.1177/14791641221118626
   Wu ZD, 1999, MOL CELL, V3, P151, DOI 10.1016/S1097-2765(00)80306-8
   Zhang XQ, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0133882
   Zhong ZH, 2010, J NEUROSCI, V30, P15521, DOI 10.1523/JNEUROSCI.4437-10.2010
NR 49
TC 6
Z9 6
U1 3
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1478-811X
J9 CELL COMMUN SIGNAL
JI Cell Commun. Signal.
PD SEP 11
PY 2023
VL 21
IS 1
AR 230
DI 10.1186/s12964-023-01254-6
PG 19
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA S3IP3
UT WOS:001070141900001
PM 37697311
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mafra, D
   Borges, NA
   Alvarenga, L
   Ribeiro, M
   Fonseca, L
   Leal, VO
   Shiels, PG
   Stenvinkel, P
AF Mafra, D.
   Borges, N. A.
   Alvarenga, L.
   Ribeiro, M.
   Fonseca, L.
   Leal, V. O.
   Shiels, P. G.
   Stenvinkel, P.
TI Fermented food: Should patients with cardiometabolic diseases go back to
   an early neolithic diet?
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Fermented food; gut microbiota; inflammation; oxidative stress;
   cardiometabolic diseases
ID LACTIC-ACID BACTERIA; DOSE-RESPONSE METAANALYSIS; RED WINE POLYPHENOLS;
   DOUBLE-BLIND; LOW-FAT; METABOLIC SYNDROME; OXIDATIVE STRESS; PROBIOTIC
   YOGURT; GUT-MICROBIOTA; LIPID PROFILE
AB Fermentation has been used since the Early Neolithic period to preserve foods. It has inherent organoleptic and nutritive properties that bestow health benefits, including reducing inflammation and oxidative stress, supporting the growth of salutogenic microbiota, enhancing intestinal mucosal protection and promoting beneficial immunometabolic health effects. The fermentation of food with specific microbiota increases the production salutogenic bioactive compounds that can activate Nrf2 mediated cytoprotective responses and mitigate the effects of the 'diseasome of aging' and its associated inflammageing, which presents as a prominent feature of obesity, type-2 diabetes, cardiovascular and chronic kidney disease. This review discusses the importance of fermented food in improving health span, with special reference to cardiometabolic diseases.
C1 [Mafra, D.; Alvarenga, L.; Fonseca, L.] Fed Fluminense Univ, Post Grad Program Med Sci, Niteroi, RJ, Brazil.
   [Mafra, D.; Ribeiro, M.] Fed Univ Rio de Janeiro UFRJ, Physiol, Grad Program Biol Sci, Rio De Janeiro, Brazil.
   [Borges, N. A.] Univ Estado Rio De Janeiro, Inst Nutr, Rio De Janeiro, Brazil.
   [Leal, V. O.] Univ Estado Rio De Janeiro, Pedro Ernesto Univ Hosp, Div Nutr, Rio De Janeiro, Brazil.
   [Shiels, P. G.] Univ Glasgow, Wolfson Wohl Translat Res Ctr, Glasgow, Lanark, Scotland.
   [Stenvinkel, P.] Karolinska Inst, Dept Clin Sci Technol & Intervent, Div Renal Med, Stockholm, Sweden.
C3 Universidade Federal Fluminense; Universidade Federal do Rio de Janeiro;
   Universidade do Estado do Rio de Janeiro; Universidade do Estado do Rio
   de Janeiro; University of Glasgow; Karolinska Institutet
RP Mafra, D (corresponding author), Fed Fluminense Univ, Post Grad Program Med Sci, Niteroi, RJ, Brazil.; Mafra, D (corresponding author), Fed Univ Rio de Janeiro UFRJ, Physiol, Grad Program Biol Sci, Rio De Janeiro, Brazil.
EM dmafra30@gmail.com
RI Borges, Natália/AFU-8397-2022; Leal, Viviane/MZR-0995-2025; Mafra,
   Denise/D-4923-2015
OI ALVARENGA, LIVIA/0000-0002-9347-8139; Fonseca,
   Larissa/0000-0002-9318-080X; Alvarenga Borges,
   Natalia/0000-0003-0898-5118; Shiels, Paul/0000-0002-7577-9843;
   Stenvinkel, Peter/0000-0002-8785-4820; Ferreira Ribeiro, Marcia
   Maria/0000-0002-4957-3630; Mafra, Denise/0000-0001-6752-6056
FU Conselho Nacional de Pesquisa (CNPq) [200162/2020-9]; Fundacao de Amparo
   a Pesquisa do Estado do Rio de Janeiro (FAPERJ) [E-26/202.524/2019]
FX This study was supported by Conselho Nacional de Pesquisa (CNPq) number
   200162/2020-9, and Fundacao de Amparo a Pesquisa do Estado do Rio de
   Janeiro (FAPERJ) number E-26/202.524/2019.
CR Abed DA, 2015, ACTA PHARM SIN B, V5, P285, DOI 10.1016/j.apsb.2015.05.008
   Agagündüz D, 2021, FOODS, V10, DOI 10.3390/foods10123099
   Agista AZ, 2021, NUTRIENTS, V13, DOI 10.3390/nu13061869
   Ahn HY, 2018, NUTR DIABETES, V8, DOI 10.1038/s41387-018-0052-y
   Ahn SB, 2018, J MICROBIOL BIOTECHN, V28, P236, DOI 10.4014/jmb.1707.07061
   Ali OSM, 2020, ENVIRON SCI POLLUT R, V27, P35161, DOI 10.1007/s11356-020-09833-7
   Alvarenga L, 2020, CLIN NUTR, V39, P3594, DOI 10.1016/j.clnu.2020.03.007
   Alvarenga LD, 2019, FOOD FUNCT, V10, P3103, DOI [10.1039/C9FO00375D, 10.1039/c9fo00375d]
   Alvarez AS, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-72161-w
   An SY, 2013, ANN NUTR METAB, V63, P111, DOI 10.1159/000353583
   Ardiansyah, 2015, BIOSCI BIOTECH BIOCH, V79, P1876, DOI 10.1080/09168451.2015.1052772
   Asgharian H, 2020, EUR J NUTR, V59, P205, DOI 10.1007/s00394-019-01900-1
   Aslam H, 2020, NUTR NEUROSCI, V23, P659, DOI 10.1080/1028415X.2018.1544332
   Aune D, 2013, AM J CLIN NUTR, V98, P1066, DOI 10.3945/ajcn.113.059030
   Ba ZY, 2021, MSPHERE, V6, DOI 10.1128/mSphere.00084-21
   Bach S, 2020, M S-MED SCI, V36, P504, DOI 10.1051/medsci/2020077
   Bae CH, 2021, J MED FOOD, V24, P569, DOI 10.1089/jmf.2020.4854
   Baruah R, 2022, J APPL MICROBIOL, V132, P3476, DOI 10.1111/jam.15444
   Bautista-Expósito S, 2019, FOOD CHEM, V274, P750, DOI 10.1016/j.foodchem.2018.09.012
   Béghin L, 2021, CLIN NUTR, V40, P778, DOI 10.1016/j.clnu.2020.07.024
   Bell V, 2018, FOODS, V7, DOI 10.3390/foods7120195
   Bellikci-Koyu E, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092089
   Beltrán-Barrientos LM, 2016, J DAIRY SCI, V99, P4099, DOI 10.3168/jds.2015-10054
   Beltrán-Barrientos LM, 2018, J DAIRY SCI, V101, P2819, DOI 10.3168/jds.2017-13189
   Bousquet J, 2021, ALLERGY, V76, P735, DOI 10.1111/all.14549
   Bücher C, 2021, COMPR REV FOOD SCI F, V20, P4299, DOI 10.1111/1541-4337.12804
   Burton KJ, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010234
   Byun MS, 2016, EUR J CLIN NUTR, V70, P1116, DOI 10.1038/ejcn.2016.77
   Cardoso RR, 2021, FOOD FUNCT, V12, P10813, DOI [10.1039/d1fo02106k, 10.1039/D1FO02106K]
   Cardozo LFMF, 2021, NUTR REV, V79, P1204, DOI 10.1093/nutrit/nuaa129
   Castro-Bravo N, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.02426
   Cha YS, 2014, J MED FOOD, V17, P119, DOI 10.1089/jmf.2013.2877
   Chan KC, 2020, FOOD NUTR RES, V64, DOI 10.29219/fnr.v64.4272
   Chaudhari DD, 2017, INDIAN J MED RES, V146, P409, DOI 10.4103/ijmr.IJMR_802_15
   Checa J, 2020, J INFLAMM RES, V13, P1057, DOI 10.2147/JIR.S275595
   Chen HY, 2016, COMPR REV FOOD SCI F, V15, P1124, DOI 10.1111/1541-4337.12228
   Chen HL, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-47872-4
   Chen M, 2014, BMC MED, V12, DOI 10.1186/s12916-014-0215-1
   Chen Y, 2019, AM J CLIN NUTR, V109, P1611, DOI 10.1093/ajcn/nqy358
   Cheng CF, 2016, J AGR FOOD CHEM, V64, P9326, DOI 10.1021/acs.jafc.6b03700
   Chiu HF, 2019, J FOOD BIOCHEM, V43, DOI 10.1111/jfbc.12994
   Chiva-Blanch G, 2013, CLIN NUTR, V32, P200, DOI 10.1016/j.clnu.2012.08.022
   Cho SK, 2015, FOOD SCI BIOTECHNOL, V24, P1443, DOI 10.1007/s10068-015-0185-x
   Choi IH, 2013, J MED FOOD, V16, P223, DOI 10.1089/jmf.2012.2563
   Craven H, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-92042-0
   Cui JW, 2020, FOOD CHEM, V333, DOI 10.1016/j.foodchem.2020.127527
   Das G, 2020, FOOD RES INT, V134, DOI 10.1016/j.foodres.2020.109269
   Derrien M, 2015, TRENDS MICROBIOL, V23, P354, DOI 10.1016/j.tim.2015.03.002
   Devanthi PVP, 2019, FOOD RES INT, V120, P364, DOI 10.1016/j.foodres.2019.03.010
   Dimidi E, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081806
   Drouin-Chartier JP, 2016, ADV NUTR, V7, P1026, DOI 10.3945/an.115.011403
   Du HP, 2019, J AGR FOOD CHEM, V67, P2839, DOI 10.1021/acs.jafc.8b06927
   Ejtahed HS, 2011, J DAIRY SCI, V94, P3288, DOI 10.3168/jds.2010-4128
   Ejtahed HS, 2012, NUTRITION, V28, P539, DOI 10.1016/j.nut.2011.08.013
   Escudero-López B, 2018, J SCI FOOD AGR, V98, P2777, DOI 10.1002/jsfa.8774
   Fathi Y, 2017, J CLIN LIPIDOL, V11, P136, DOI 10.1016/j.jacl.2016.10.016
   Fuda H, 2019, J AGR FOOD CHEM, V67, P12844, DOI 10.1021/acs.jafc.9b04600
   Gao DQ, 2013, NANOSCALE RES LETT, V8, DOI 10.1186/1556-276X-8-129
   García-Burgos M, 2022, J SCI FOOD AGR, V102, P1114, DOI 10.1002/jsfa.11448
   Garcia-Gonzalez N, 2021, MICROORGANISMS, V9, DOI 10.3390/microorganisms9020349
   Gijsbers L, 2016, AM J CLIN NUTR, V103, P1111, DOI 10.3945/ajcn.115.123216
   Gille D, 2018, NUTRIENTS, V10, DOI 10.3390/nu10040448
   Golan R, 2018, EUR J CLIN NUTR, V72, P871, DOI 10.1038/s41430-018-0091-4
   Golan R, 2017, PUBLIC HEALTH NUTR, V20, P549, DOI 10.1017/S1368980016002597
   Guillemard E, 2021, NUTRIENTS, V13, DOI 10.3390/nu13093171
   Hall KD, 2020, CELL METAB, V32, P690, DOI 10.1016/j.cmet.2020.08.014
   Han K, 2015, MOL NUTR FOOD RES, V59, P1004, DOI 10.1002/mnfr.201400780
   He LX, 2020, NUTRIENTS, V12, DOI 10.3390/nu12082376
   Hove KD, 2015, EUR J ENDOCRINOL, V172, DOI 10.1530/EJE-14-0554
   Hric I, 2021, NUTRIENTS, V13, DOI 10.3390/nu13061753
   Huang Y., 2017, DESTECH T SOCIAL SCI, P1307, DOI 10.12783/dtssehs/icss2016/9181
   Huang ZJ, 2021, INVEST OPHTH VIS SCI, V62, DOI 10.1167/iovs.62.6.25
   Hütt P, 2015, BENEF MICROBES, V6, P233, DOI 10.3920/BM2014.0035
   Islam MS, 2009, J MED FOOD, V12, P292, DOI 10.1089/jmf.2008.0181
   Ito M, 2017, BENEF MICROBES, V8, P171, DOI 10.3920/BM2016.0102
   Jakubowicz D, 2013, J NUTR BIOCHEM, V24, P1, DOI [10.1016/j.jnutbio.2012.07.008, 10.1016/j.jnutbio.2013.06.003]
   Jeong CH, 2018, FOOD SCI BIOTECHNOL, V27, P1419, DOI 10.1007/s10068-018-0370-9
   Jeong JW, 2019, FOODS, V8, DOI 10.3390/foods8080290
   Jespersen T, 2018, NUTR METAB CARDIOVAS, V28, P1133, DOI 10.1016/j.numecd.2018.06.018
   Jhee JH, 2019, AM J KIDNEY DIS, V74, P491, DOI 10.1053/j.ajkd.2019.02.023
   Jung JY, 2015, INT IMMUNOPHARMACOL, V28, P88, DOI 10.1016/j.intimp.2015.05.037
   Jung SM, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020535
   Kageyama S, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124466
   Kårlund A, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041020
   Kaur H, 2021, FOOD FUNCT, V12, P6102, DOI [10.1039/d0fo02641g, 10.1039/D0FO02641G]
   Khan MM, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9100934
   Kim DH, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201700252
   Kim E, 2021, J AGR FOOD CHEM, V69, P15157, DOI 10.1021/acs.jafc.1c05037
   Kim EK, 2011, NUTR RES, V31, P436, DOI 10.1016/j.nutres.2011.05.011
   Kim HY, 2020, FOOD SCI BIOTECHNOL, V29, P569, DOI 10.1007/s10068-019-00690-w
   Kim I, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22115746
   Kim S, 2018, J MED FOOD, V21, P489, DOI 10.1089/jmf.2017.4103
   Kim SY, 2021, FOODS, V10, DOI 10.3390/foods10112807
   Kim SM, 2020, LIFE-BASEL, V10, DOI 10.3390/life10110293
   Kojima A, 2020, J NUTR, V150, P599, DOI 10.1093/jn/nxz292
   Kumar MR, 2021, BMC COMPLEMENT MED, V21, DOI 10.1186/s12906-021-03358-3
   Kumar Naresh, 2019, Biotechnology Reports, V24, pe00370, DOI 10.1016/j.btre.2019.e00370
   La Marca M, 2015, CELL MOL BIOL LETT, V20, P102, DOI 10.1515/cmble-2015-0007
   Lee CS, 2021, J APPL MICROBIOL, V130, P2041, DOI 10.1111/jam.14852
   Lee DY, 2016, J MED FOOD, V19, P1147, DOI 10.1089/jmf.2016.3742
   Lee Y, 2017, J MED FOOD, V20, P610, DOI 10.1089/jmf.2016.3911
   Lin XN, 2018, J FOOD SCI, V83, P1990, DOI 10.1111/1750-3841.14200
   Liu T, 2017, SIGNAL TRANSDUCT TAR, V2, DOI 10.1038/sigtrans.2017.23
   Liu YW, 2021, FOOD FUNCT, V12, P9141, DOI [10.1039/D1FO01423D, 10.1039/d1fo01423d]
   Madjd A, 2016, AM J CLIN NUTR, V103, P323, DOI 10.3945/ajcn.115.120170
   Mafra D, 2021, NAT REV NEPHROL, V17, P153, DOI 10.1038/s41581-020-00345-8
   Mafra D, 2019, NUTRIENTS, V11, DOI 10.3390/nu11030496
   Mamo G, 2016, ADV BIOCHEM ENG BIOT, V156, P433, DOI 10.1007/10_2016_6
   Manzanarez-Quín CG, 2021, J DAIRY SCI, V104, P3766, DOI 10.3168/jds.2020-19256
   Marco ML, 2021, NAT REV GASTRO HEPAT, V18, P196, DOI 10.1038/s41575-020-00390-5
   Marco ML, 2020, J NUTR, V150, P3061, DOI 10.1093/jn/nxaa323
   Marco ML, 2017, CURR OPIN BIOTECH, V44, P94, DOI 10.1016/j.copbio.2016.11.010
   Márquez-Morales L, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051551
   Mathur H, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061679
   Meijers BKI, 2011, NEPHROL DIAL TRANSPL, V26, P759, DOI 10.1093/ndt/gfq818
   Melnik BC, 2021, AGEING RES REV, V67, DOI 10.1016/j.arr.2021.101270
   Merenstein D, 2021, NUTRIENTS, V13, DOI 10.3390/nu13082814
   Migliori M, 2015, BLOOD PURIFICAT, V39, P218, DOI 10.1159/000371570
   Minamiyama Y, 2002, BIOFACTORS, V16, P105, DOI 10.1002/biof.5520160306
   Mohajeri MH, 2018, EUR J NUTR, V57, pS1, DOI 10.1007/s00394-018-1703-4
   Mohamed WA, 2018, DIABETOL METAB SYNDR, V10, DOI 10.1186/s13098-018-0390-x
   Mohammadi-Sartang M, 2018, NUTR METAB CARDIOVAS, V28, P565, DOI 10.1016/j.numecd.2018.03.001
   Monmai C, 2021, FOOD SCI BIOTECHNOL, V30, P1409, DOI 10.1007/s10068-021-00929-5
   Moreno-Fernandez J, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-37649-6
   Moreno-Indias I, 2016, FOOD FUNCT, V7, P1775, DOI [10.1039/C5FO00886G, 10.1039/c5fo00886g]
   Moschen AR, 2012, GUT LIVER, V6, P411, DOI 10.5009/gnl.2012.6.4.411
   Nagino T, 2018, BENEF MICROBES, V9, P209, DOI [10.3920/BM2017.0091, 10.3920/bm2017.0091]
   Nakamura T, 2009, METABOLISM, V58, P1185, DOI 10.1016/j.metabol.2009.03.019
   Nestel PJ, 2022, CURR ATHEROSCLER REP, V24, P33, DOI 10.1007/s11883-022-00984-1
   Nestel PJ, 2013, BRIT J NUTR, V110, P2242, DOI 10.1017/S0007114513001621
   Nielsen ES, 2018, FOOD FUNCT, V9, P5323, DOI [10.1039/c8fo00968f, 10.1039/C8FO00968F]
   Nikooyeh B, 2021, NUTR DIABETES, V11, DOI 10.1038/s41387-021-00168-x
   Noer ER, 2021, OBES RES CLIN PRACT, V15, P339, DOI 10.1016/j.orcp.2021.06.005
   Oerlemans MMP, 2021, J FUNCT FOODS, V76, DOI 10.1016/j.jff.2020.104289
   Oh MR, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-237
   Pan RR, 2020, J FOOD BIOCHEM, V44, DOI 10.1111/jfbc.13471
   Pápai G, 2021, PROBIOTICS ANTIMICRO, V13, P484, DOI 10.1007/s12602-020-09702-2
   Paparo L, 2021, J FUNCT FOODS, V87, DOI 10.1016/j.jff.2021.104787
   Park C, 2020, EXCLI J, V19, P1102, DOI 10.17179/excli2020-2376
   Pothuraju R, 2016, BENEF MICROBES, V7, P375, DOI 10.3920/BM2015.0083
   Poutanen K, 2009, FOOD MICROBIOL, V26, P693, DOI 10.1016/j.fm.2009.07.011
   Prasetyo RV, 2020, BENEF MICROBES, V11, P59, DOI 10.3920/BM2019.0036
   Praznikar ZJ, 2020, J DAIRY SCI, V103, P3961, DOI 10.3168/jds.2019-17696
   Qian Y, 2018, MOLECULES, V23, DOI 10.3390/molecules23113026
   Rai AK, 2017, CRIT REV FOOD SCI, V57, P2789, DOI 10.1080/10408398.2015.1068736
   Razmpoosh E, 2020, CLIN NUTR ESPEN, V35, P194, DOI 10.1016/j.clnesp.2019.10.001
   Rezac S, 2018, FRONT MICROBIOL, V9, DOI 10.3389/fmicb.2018.01785
   Rezazadeh L, 2019, NUTRITION, V62, P162, DOI 10.1016/j.nut.2018.12.011
   Rice BH, 2011, ADV NUTR, V2, P396, DOI 10.3945/an.111.000646
   Rundblad A, 2020, MOL NUTR FOOD RES, V64, DOI 10.1002/mnfr.202000319
   Salari A, 2021, COMPLEMENT THER CLIN, V44, DOI 10.1016/j.ctcp.2021.101443
   Salazar N, 2016, CRIT REV FOOD SCI, V56, P1440, DOI 10.1080/10408398.2013.770728
   Sanlier N, 2019, CRIT REV FOOD SCI, V59, P506, DOI 10.1080/10408398.2017.1383355
   Santurino C, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051315
   Schmidt KA, 2021, AM J CLIN NUTR, V113, P534, DOI 10.1093/ajcn/nqaa301
   Schnorr SL, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4654
   Senger DR, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0148042
   Seo DB, 2017, BRIT J NUTR, V117, P177, DOI [10.1017/S0007114516004621, 10.1017/s0007114516004621]
   Sha J, 2022, FOODS, V11, DOI 10.3390/foods11010080
   Shiels PG, 2021, BIOCHEM J, V478, P2889, DOI 10.1042/BCJ20200958
   Shiels PG, 2017, NAT REV NEPHROL, V13, P471, DOI 10.1038/nrneph.2017.78
   Sibbesson E, 2022, ENVIRON ARCHAEOL, V27, P111, DOI 10.1080/14614103.2018.1563374
   Silva FM, 2022, EUR J NUTR, V61, P859, DOI 10.1007/s00394-021-02686-x
   Sirilun S, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11020305
   Slattery C, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061252
   Snelson M, 2021, SCI ADV, V7, DOI 10.1126/sciadv.abe4841
   Sonnenburg JL, 2019, SCIENCE, V366, P444, DOI 10.1126/science.aaw9255
   Stenvinkel P, 2020, NEPHROL DIAL TRANSPL, V35, P2036, DOI 10.1093/ndt/gfz120
   STRACHAN DP, 1989, BRIT MED J, V299, P1259, DOI 10.1136/bmj.299.6710.1259
   Sun SR, 2017, PHYSIOLOGY, V32, P453, DOI 10.1152/physiol.00016.2017
   Suo HY, 2015, MOLECULES, V20, P19748, DOI 10.3390/molecules201119654
   Szkudelski T, 2011, ANN NY ACAD SCI, V1215, P34, DOI 10.1111/j.1749-6632.2010.05844.x
   Takahashi F, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051488
   Tamang JP, 2022, J APPL MICROBIOL, V132, P3533, DOI 10.1111/jam.15467
   Tenore GC, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010122
   Thorning Tanja K, 2015, Am J Clin Nutr, V102, P573, DOI 10.3945/ajcn.115.109116
   Tobita K, 2022, J FOOD BIOCHEM, V46, DOI 10.1111/jfbc.14046
   Tonolo F, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9121306
   Tonucci LB, 2017, CLIN NUTR, V36, P85, DOI 10.1016/j.clnu.2015.11.011
   Torres S, 2019, EUR J NUTR, V58, P27, DOI 10.1007/s00394-018-1790-2
   Toshimitsu T, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020374
   Turroni S, 2016, SCI REP-UK, V6, DOI 10.1038/srep32826
   Udenigwe CC, 2014, J FUNCT FOODS, V8, P45, DOI 10.1016/j.jff.2014.03.002
   Usinger L, 2010, J HUM HYPERTENS, V24, P678, DOI 10.1038/jhh.2010.4
   Voidarou C, 2021, FOODS, V10, DOI 10.3390/foods10010069
   Wang PH, 2021, FOOD FUNCT, V12, P10263, DOI [10.1039/d1fo01839f, 10.1039/D1FO01839F]
   Wang R, 2021, BENEF MICROBES, V12, P31, DOI 10.3920/BM2020.0023
   Wastyk Hannah C, 2021, Cell, V184, P4137, DOI 10.1016/j.cell.2021.06.019
   Welman AD, 2003, TRENDS BIOTECHNOL, V21, P269, DOI 10.1016/S0167-7799(03)00107-0
   Wu H, 2022, FRONT NUTR, V8, DOI 10.3389/fnut.2021.790765
   Wu PS, 2018, J AGR FOOD CHEM, V66, P5790, DOI 10.1021/acs.jafc.8b00437
   Xi YM, 2020, ANIMALS-BASEL, V10, DOI 10.3390/ani10112139
   Xia T, 2018, NUTRIENTS, V10, DOI 10.3390/nu10070805
   Xiao YX, 2020, BMC MICROBIOL, V20, DOI 10.1186/s12866-020-01874-9
   Yacoub R, 2016, NUTR J, V15, DOI 10.1186/s12937-016-0127-3
   Yang HJ, 2022, FRONT NUTR, V8, DOI 10.3389/fnut.2021.772347
   Yanni AE, 2019, FOOD FUNCT, V10, P7435, DOI [10.1039/C9FO01796H, 10.1039/c9fo01796h]
   Yao KC, 2017, MED SCI MONITOR, V23, DOI 10.12659/MSM.902600
   Yilmaz I, 2019, TURK J GASTROENTEROL, V30, P242, DOI 10.5152/tjg.2018.18227
   Yoo JH, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030808
   Yu SF, 2022, FOOD FUNCT, V13, P3343, DOI [10.1039/d1fo03941e, 10.1039/D1FO03941E]
   Zareian M, 2020, FOOD FUNCT, V11, P4304, DOI [10.1039/c9fo02854d, 10.1039/C9FO02854D]
   Zarrati M, 2019, PROBIOTICS ANTIMICRO, V11, P1202, DOI 10.1007/s12602-018-9470-3
   Zeng XJ, 2021, FOOD FUNCT, V12, P11641, DOI [10.1039/d1fo01729b, 10.1039/D1FO01729B]
   Zhang XM, 2021, NUTRIENTS, V13, DOI 10.3390/nu13072238
   Zhao DY, 2016, J NUTR BIOCHEM, V38, P116, DOI 10.1016/j.jnutbio.2016.09.005
   Zhou F, 2021, J AGR FOOD CHEM, V69, P14530, DOI 10.1021/acs.jafc.1c04553
NR 207
TC 5
Z9 5
U1 5
U2 65
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD NOV 17
PY 2023
VL 63
IS 29
BP 10173
EP 10196
DI 10.1080/10408398.2022.2077300
EA MAY 2022
PG 24
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA HN6E5
UT WOS:000798134100001
PM 35593230
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Linta, AV
   Lolescu, BM
   Ilie, CA
   Vlad, M
   Blidisel, A
   Sturza, A
   Borza, C
   Muntean, DM
   Cretu, OM
AF Linta, Adina V.
   Lolescu, Bogdan M.
   Ilie, Cosmin A.
   Vlad, Mihaela
   Blidisel, Alexandru
   Sturza, Adrian
   Borza, Claudia
   Muntean, Danina M.
   Cretu, Octavian M.
TI Liver and Pancreatic Toxicity of Endocrine-Disruptive Chemicals: Focus
   on Mitochondrial Dysfunction and Oxidative Stress
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE endocrine disruptors; metabolism-disrupting chemicals; liver; pancreas;
   mitochondrial dysfunction; oxidative stress
ID BETA-CELL FUNCTION; BISPHENOL-A; PERINATAL EXPOSURE; FATTY LIVER;
   OBESITY; HEALTH; DAMAGE; RATS; METABOLISM; ATRAZINE
AB In recent years, the worldwide epidemic of metabolic diseases, namely obesity, metabolic syndrome, diabetes and metabolic-associated fatty liver disease (MAFLD) has been strongly associated with constant exposure to endocrine-disruptive chemicals (EDCs), in particular, the ones able to disrupt various metabolic pathways. EDCs have a negative impact on several human tissues/systems, including metabolically active organs, such as the liver and pancreas. Among their deleterious effects, EDCs induce mitochondrial dysfunction and oxidative stress, which are also the major pathophysiological mechanisms underlying metabolic diseases. In this narrative review, we delve into the current literature on EDC toxicity effects on the liver and pancreatic tissues in terms of impaired mitochondrial function and redox homeostasis.
C1 [Linta, Adina V.; Sturza, Adrian; Borza, Claudia; Muntean, Danina M.] Victor Babes Univ Med & Pharm Timisoara, Dept Funct Sci, Chair Pathophysiol, E Murgu Sq 2, Timisoara 300041, Romania.
   [Linta, Adina V.; Lolescu, Bogdan M.; Ilie, Cosmin A.; Sturza, Adrian; Borza, Claudia; Muntean, Danina M.] Victor Babes Univ Med & Pharm Timisoara, Ctr Translat Res & Syst Med, E Murgu Sq 2, Timisoara 300041, Romania.
   [Linta, Adina V.; Lolescu, Bogdan M.] Victor Babes Univ Med & Pharm Timisoara, Doctoral Sch Med Pharm, E Murgu Sq 2, Timisoara 300041, Romania.
   [Ilie, Cosmin A.] Victor Babes Univ Med & Pharm Timisoara, Chair Publ Hlth & Sanit Management, Dept Funct Sci, E Murgu Sq 2, Timisoara 300041, Romania.
   [Vlad, Mihaela] Victor Babes Univ Med & Pharm Timisoara, Chair Endocrinol, Dept Internal Med 2, E Murgu Sq 2, Timisoara 300041, Romania.
   [Blidisel, Alexandru; Cretu, Octavian M.] Victor Babes Univ Med & Pharm Timisoara, Chair Surg Semiot & Thorac Surg, Dept Surg 1, E Murgu Sq 2, Timisoara 300041, Romania.
   [Blidisel, Alexandru; Cretu, Octavian M.] Victor Babes Univ Med & Pharm Timisoara, Ctr Hepatobiliary & Pancreat Surg, E Murgu Sq 2, Timisoara 300041, Romania.
C3 Victor Babes University of Medicine & Pharmacy, Timisoara; Victor Babes
   University of Medicine & Pharmacy, Timisoara; Victor Babes University of
   Medicine & Pharmacy, Timisoara; Victor Babes University of Medicine &
   Pharmacy, Timisoara; Victor Babes University of Medicine & Pharmacy,
   Timisoara; Victor Babes University of Medicine & Pharmacy, Timisoara;
   Victor Babes University of Medicine & Pharmacy, Timisoara
RP Muntean, DM (corresponding author), Victor Babes Univ Med & Pharm Timisoara, Dept Funct Sci, Chair Pathophysiol, E Murgu Sq 2, Timisoara 300041, Romania.; Muntean, DM (corresponding author), Victor Babes Univ Med & Pharm Timisoara, Ctr Translat Res & Syst Med, E Murgu Sq 2, Timisoara 300041, Romania.
EM adina.linta@umft.ro; bogdan.lolescu@umft.ro; ilie.adrian@umft.ro;
   vlad.mihaela@umft.ro; blidy@umft.ro; sturza.adrian@umft.ro;
   borza.claudia@umft.ro; daninamuntean@umft.ro; octavian.cretu@umft.ro
RI Cretu, Octavian/LWH-8125-2024; Vlad, Mihaela/JAN-8553-2023; Sturza,
   Adrian/AAL-8869-2020; Muntean, Danina Mirela/G-3138-2016; Furdui'Linta,
   Adina/LSL-0957-2024; claudia, Borza/ABH-5975-2020
OI Blidisel, Alexandru/0000-0001-6528-7733; Vlad,
   Mihaela/0000-0002-0276-1650
FU The "Victor Babes," University of Medicine and Pharmacy of Timisoara
FX We would like to acknowledge the support of "Victor Babes," University
   of Medicine and Pharmacy of Timisoara, in covering the costs of
   publication for this paper.
CR Afzal G, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/5450421
   Ahn C, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24065342
   Alharbi HF, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph192315918
   Amato AA, 2021, ENDOCR CONNECT, V10, pR87, DOI 10.1530/EC-20-0578
   Antonucci S, 2021, CELL CALCIUM, V94, DOI 10.1016/j.ceca.2020.102344
   Avram VF, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23168852
   Azevedo LF, 2020, ENVIRON RES, V182, DOI 10.1016/j.envres.2019.109080
   Baillie-Hamilton PF, 2002, J ALTERN COMPLEM MED, V8, P185, DOI 10.1089/107555302317371479
   Bansal A, 2017, ENVIRON HEALTH PERSP, V125, DOI 10.1289/EHP1674
   Bergman Å, 2013, ENVIRON HEALTH PERSP, V121, pA104, DOI 10.1289/ehp.1205448
   Bianchi S, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17072580
   Bindhumol V, 2003, TOXICOLOGY, V188, P117, DOI 10.1016/S0300-483X(03)00056-8
   Blajszczak C, 2017, TOXICOLOGY, V391, P84, DOI 10.1016/j.tox.2017.07.013
   Bleier L, 2015, FREE RADICAL BIO MED, V78, P1, DOI 10.1016/j.freeradbiomed.2014.10.511
   Brown RE, 2016, OBES RES CLIN PRACT, V10, P243, DOI 10.1016/j.orcp.2015.08.007
   Carchia E, 2015, CELL DEATH DIS, V6, DOI 10.1038/cddis.2015.319
   Chen H, 2016, ENVIRON TOXICOL PHAR, V42, P38, DOI 10.1016/j.etap.2015.12.016
   Chen J, 2018, ANTIOXID REDOX SIGN, V29, P1361, DOI 10.1089/ars.2017.7346
   Chen TT, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18122507
   Chen YW, 2017, ARCH TOXICOL, V91, P3135, DOI 10.1007/s00204-017-1940-y
   COLBORN T, 1993, ENVIRON HEALTH PERSP, V101, P378, DOI 10.2307/3431890
   Corkey BE, 2023, PHILOS T R SOC B, V378, DOI 10.1098/rstb.2022.0210
   Deng P, 2019, CHEMOSPHERE, V217, P140, DOI 10.1016/j.chemosphere.2018.10.196
   Dhakal K, 2018, ENVIRON SCI POLLUT R, V25, P16277, DOI 10.1007/s11356-017-9694-x
   Domingo JL, 2006, ENVIRON INT, V32, P121, DOI 10.1016/j.envint.2005.05.021
   Dos Santos RS, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24010231
   Duh-Leong C, 2023, NAT REV ENDOCRINOL, DOI 10.1038/s41574-023-00872-x
   Espina C, 2015, CANCER EPIDEMIOL, V39, pS84, DOI 10.1016/j.canep.2015.03.017
   Eweda SM, 2020, EXP THER MED, V19, P33, DOI 10.3892/etm.2019.8193
   Fritsche K, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24032686
   Fu HY, 2024, SCI TOTAL ENVIRON, V928, DOI 10.1016/j.scitotenv.2024.171711
   Grün F, 2006, ENDOCRINOLOGY, V147, pS50, DOI 10.1210/en.2005-1129
   Gupta P, 2018, DRUG DELIV TRANSL RE, V8, P740, DOI 10.1007/s13346-017-0429-9
   Halden RU, 2010, ANNU REV PUBL HEALTH, V31, P179, DOI 10.1146/annurev.publhealth.012809.103714
   Han CY, 2023, ECOTOX ENVIRON SAFE, V257, DOI 10.1016/j.ecoenv.2023.114938
   Han R, 2018, CHEMOSPHERE, V191, P1056, DOI 10.1016/j.chemosphere.2017.08.070
   Hartsoe P, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25052944
   Hassan ZK, 2012, OXID MED CELL LONGEV, V2012, DOI 10.1155/2012/194829
   Hassani FV, 2018, FOOD CHEM TOXICOL, V112, P26, DOI 10.1016/j.fct.2017.12.021
   Heindel JJ, 2024, INT J OBESITY, V48, P449, DOI 10.1038/s41366-024-01460-3
   Heindel JJ, 2019, ANNU REV PHARMACOL, V59, P89, DOI 10.1146/annurev-pharmtox-010818-021304
   Heindel JJ, 2017, REPROD TOXICOL, V68, P3, DOI 10.1016/j.reprotox.2016.10.001
   Hinault C, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24054537
   Huang ZQ, 2020, J BIOSCIENCES, V45, DOI 10.1007/s12038-020-00055-0
   Huc L, 2012, TOXICOL IN VITRO, V26, P709, DOI 10.1016/j.tiv.2012.03.017
   Ijaz MU, 2022, SAUDI J BIOL SCI, V29, P1375, DOI 10.1016/j.sjbs.2021.11.007
   Jaacks LM, 2019, LANCET DIABETES ENDO, V7, P231, DOI 10.1016/S2213-8587(19)30026-9
   Jiang Y, 2014, TOXICOL LETT, V228, P85, DOI 10.1016/j.toxlet.2014.04.013
   Jin YX, 2014, ENVIRON TOXICOL PHAR, V37, P782, DOI 10.1016/j.etap.2014.02.014
   Khan NG, 2023, BBA-MOL CELL RES, V1870, DOI 10.1016/j.bbamcr.2023.119505
   Khan S, 2016, ENVIRON TOXICOL, V31, P1922, DOI 10.1002/tox.22193
   Kim K, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25073818
   Kourouma A., 2015, ADV TOXICOL, V2015, P1, DOI [https://doi.org/10.1155/2015/901983, DOI 10.1155/2015/901983, 10.1155/2015/901983]
   Küblbeck J, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21083021
   La Merrill M, 2011, MT SINAI J MED, V78, P22, DOI 10.1002/msj.20229
   Lang IA, 2008, JAMA-J AM MED ASSOC, V300, P1303, DOI 10.1001/jama.300.11.1303
   Lee CY, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17113802
   Lee JL, 2022, TOXICS, V10, DOI 10.3390/toxics10050208
   Lee KI, 2016, ARCH TOXICOL, V90, P1211, DOI 10.1007/s00204-015-1539-0
   Leung MCK, 2019, REPROD TOXICOL, V89, P83, DOI 10.1016/j.reprotox.2019.07.007
   Li CL, 2024, BIOMEDICINES, V12, DOI 10.3390/biomedicines12040814
   Li G, 2021, ECOTOX ENVIRON SAFE, V228, DOI 10.1016/j.ecoenv.2021.112988
   Li XJ, 2017, TOXICOL RES-UK, V6, P353, DOI 10.1039/c6tx00450d
   Linillos-Pradillo B, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24054585
   Liu KY, 2023, LIFE SCI, V326, DOI 10.1016/j.lfs.2023.121752
   Liu RJ, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23148042
   Lopez-Jimenez F, 2022, EUR J PREV CARDIOL, V29, P2218, DOI 10.1093/eurjpc/zwac187
   Makaji E, 2011, INT J TOXICOL, V30, P410, DOI 10.1177/1091581811405544
   Margina Denisa, 2019, World Acad Sci J, V1, P157, DOI 10.3892/wasj.2019.17
   Marroqui L, 2018, J ENDOCRINOL, V239, pR27, DOI 10.1530/JOE-18-0362
   Massart J, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23031062
   McCann MS, 2021, NEUROTOXICOLOGY, V86, P59, DOI 10.1016/j.neuro.2021.07.001
   Meng ZY, 2019, ENVIRON POLLUT, V247, P935, DOI 10.1016/j.envpol.2019.01.116
   Meyer JN, 2017, TOXICOLOGY, V391, P2, DOI 10.1016/j.tox.2017.06.002
   Monzel AS, 2023, NAT METAB, V5, P546, DOI 10.1038/s42255-023-00783-1
   Moon MK, 2015, J ENDOCRINOL, V226, P35, DOI 10.1530/JOE-14-0714
   Moon MK, 2012, J KOREAN MED SCI, V27, P644, DOI 10.3346/jkms.2012.27.6.644
   Mornagui B, 2022, J CELL PHYSIOL, V237, P3057, DOI 10.1002/jcp.30771
   Mosca A, 2024, METABOLITES, V14, DOI 10.3390/metabo14010071
   Mourokh L, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25052835
   Mukherjee U, 2022, CHEM-BIOL INTERACT, V351, DOI 10.1016/j.cbi.2021.109762
   Muntean DM, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/8254942
   Nagarajan M, 2024, FOOD CHEM TOXICOL, V183, DOI 10.1016/j.fct.2023.114197
   National Center for Biotechnology Information, 2024, PUBCHEM COMPOUND SUM
   National Toxicology Program, 2006, Natl Toxicol Program Tech Rep Ser, P1
   Neel BA, 2011, DIABETES, V60, P1838, DOI 10.2337/db11-0153
   Nickel A, 2014, J MOL CELL CARDIOL, V73, P26, DOI 10.1016/j.yjmcc.2014.03.011
   Ounnas F, 2016, CHEMOSPHERE, V161, P80, DOI 10.1016/j.chemosphere.2016.06.040
   Papalou O, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00112
   Park CG, 2020, COMP BIOCHEM PHYS C, V230, DOI 10.1016/j.cbpc.2020.108704
   Picard M, 2022, CELL METAB, V34, P1620, DOI 10.1016/j.cmet.2022.10.008
   Pirozzi C, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9121201
   Preda A, 2023, REV ENDOCR METAB DIS, V24, P901, DOI 10.1007/s11154-023-09813-5
   Predieri B, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21082937
   Qiu WH, 2016, ECOTOX ENVIRON SAFE, V130, P93, DOI 10.1016/j.ecoenv.2016.04.014
   Rancière F, 2015, ENVIRON HEALTH-GLOB, V14, DOI 10.1186/s12940-015-0036-5
   Reddam A, 2022, CURR ENV HLTH REP, V9, P631, DOI 10.1007/s40572-022-00371-7
   Ribeiro E, 2017, TOXICS, V5, DOI 10.3390/toxics5010005
   Sagarkar S, 2016, INDIAN J PHARMACOL, V48, P200, DOI 10.4103/0253-7613.178842
   Schnegelberger RD, 2021, ACTA PHARM SIN B, V11, P3756, DOI 10.1016/j.apsb.2021.09.002
   Schwartz MW, 2017, ENDOCR REV, V38, P267, DOI 10.1210/er.2017-00111
   Mahim SS, 2021, J BIOCHEM MOL TOXIC, V35, DOI 10.1002/jbt.22820
   Shi R, 2021, IMMUNOPHARM IMMUNOT, V43, P527, DOI 10.1080/08923973.2021.1950179
   Song LQ, 2012, J ENDOCRINOL, V215, P303, DOI 10.1530/JOE-12-0219
   Stefunková N, 2024, LIFE-BASEL, V14, DOI 10.3390/life14010003
   Susiarjo M, 2015, ENDOCRINOLOGY, V156, P2049, DOI 10.1210/en.2014-2027
   Tickner JA, 2001, AM J IND MED, V39, P100, DOI 10.1002/1097-0274(200101)39:1<100::AID-AJIM10>3.0.CO;2-Q
   Tsatsakis A, 2019, TOXICOL LETT, V309, P33, DOI 10.1016/j.toxlet.2018.12.003
   Van den Berg M, 2006, TOXICOL SCI, V93, P223, DOI 10.1093/toxsci/kfl055
   Vandenberg LN, 2009, ENDOCR REV, V30, P75, DOI 10.1210/er.2008-0021
   VanEtten SL, 2021, TOXICOLOGY, V454, DOI 10.1016/j.tox.2021.152744
   Vardakas P, 2022, TOXICS, V10, DOI 10.3390/toxics10040190
   Wang K, 2019, BIOMED PHARMACOTHER, V117, DOI 10.1016/j.biopha.2019.109182
   Wei J, 2011, ENDOCRINOLOGY, V152, P3049, DOI 10.1210/en.2011-0045
   Xia W, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0090443
   Ye CM, 2022, FRONT PHYSIOL, V13, DOI 10.3389/fphys.2022.907906
   Zhang H, 2022, ENVIRON POLLUT, V292, DOI 10.1016/j.envpol.2021.118444
   Zhang Q, 2019, SCI TOTAL ENVIRON, V651, P885, DOI 10.1016/j.scitotenv.2018.09.211
   Zhang R, 2016, J AGR FOOD CHEM, V64, P6630, DOI 10.1021/acs.jafc.6b02656
   Zhao JF, 2016, ARCH TOXICOL, V90, P181, DOI 10.1007/s00204-014-1377-5
NR 120
TC 4
Z9 4
U1 10
U2 22
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL
PY 2024
VL 25
IS 13
AR 7420
DI 10.3390/ijms25137420
PG 25
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA YP4G9
UT WOS:001269670300001
PM 39000526
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Deng, YW
   Liu, F
   Yang, XL
   Xia, YL
AF Deng, Yawen
   Liu, Fei
   Yang, Xiaolei
   Xia, Yunlong
TI The Key Role of Uric Acid in Oxidative Stress, Inflammation, Fibrosis,
   Apoptosis, and Immunity in the Pathogenesis of Atrial Fibrillation
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE uric acid; atrial fibrillation; mechanisms; oxidative stress;
   inflammation
ID MUSCLE-CELL-PROLIFERATION; C-REACTIVE PROTEIN; METABOLIC SYNDROME;
   XANTHINE-OXIDASE; CARDIOVASCULAR-DISEASE; INCREASED PREVALENCE;
   NITRIC-OXIDE; HYPERURICEMIA; ASSOCIATION; PATHOPHYSIOLOGY
AB Atrial fibrillation (AF) is a highly prevalent cardiac arrhythmia that leads to numerous adverse outcomes including stroke, heart failure, and death. Hyperuricemia is an important risk factor that contributes to atrium injury and AF, but the underlying molecular mechanism remains to be elucidated. In this review, we discussed the scientific evidence for clarifying the role of hyperuricemia in the pathogenesis of AF. Experimental and Clinical evidence endorse hyperuricemia as an independent risk factor for the incidence of AF. Various in vivo and in vitro investigations showed that hyperuricemia might play a critical role in the pathogenesis of AF at different UA concentrations through the activation of oxidative stress, inflammation, fibrosis, apoptosis, and immunity.
C1 [Deng, Yawen; Liu, Fei; Yang, Xiaolei; Xia, Yunlong] Dalian Med Univ, Affiliated Hosp 1, Dept Cardiol, Dalian, Peoples R China.
C3 Dalian Medical University
RP Yang, XL; Xia, YL (corresponding author), Dalian Med Univ, Affiliated Hosp 1, Dept Cardiol, Dalian, Peoples R China.
EM 15942456079@yeah.net; yunlong_xia@126.com
CR Anzai N, 2008, J BIOL CHEM, V283, P26834, DOI 10.1074/jbc.C800156200
   Baldwin W, 2011, DIABETES, V60, P1258, DOI 10.2337/db10-0916
   Benjamin EJ, 2019, CIRCULATION, V139, pE56, DOI [10.1161/CIR.0000000000000659, 10.1161/CIR.0000000000000746]
   Chao TF, 2013, INT J CARDIOL, V168, P4027, DOI 10.1016/j.ijcard.2013.06.067
   Chen CC, 2011, AM J PHYSIOL-HEART C, V301, pH1107, DOI 10.1152/ajpheart.01071.2010
   Chen CJ, 2006, J CLIN INVEST, V116, P2262, DOI 10.1172/JCI28075
   Chen PS, 2014, CIRC RES, V114, P1500, DOI 10.1161/CIRCRESAHA.114.303772
   Chen Y, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2017-019037
   Cheng TH, 2010, INT J CARDIOL, V139, P42, DOI 10.1016/j.ijcard.2008.09.004
   Choi HK, 2007, AM J MED, V120, P442, DOI 10.1016/j.amjmed.2006.06.040
   Chugh SS, 2014, CIRCULATION, V129, P837, DOI 10.1161/CIRCULATIONAHA.113.005119
   Convento MS, 2011, UROL RES, V39, P21, DOI 10.1007/s00240-010-0282-5
   Corry DB, 2008, J HYPERTENS, V26, P269, DOI 10.1097/HJH.0b013e3282f240bf
   Doehner W, 2011, SEMIN NEPHROL, V31, P433, DOI 10.1016/j.semnephrol.2011.08.007
   Feig DI, 2008, NEW ENGL J MED, V359, P1811, DOI 10.1056/NEJMra0800885
   Gao G, 2009, ANTIOXID REDOX SIGN, V11, P2265, DOI [10.1089/ars.2009.2595, 10.1089/ARS.2009.2595]
   Gersch C, 2008, NUCLEOS NUCLEOT NUCL, V27, P967, DOI 10.1080/15257770802257952
   Glantzounis GK, 2005, CURR PHARM DESIGN, V11, P4145, DOI 10.2174/138161205774913255
   Han HJ, 2007, AM J PHYSIOL-RENAL, V292, pF373, DOI 10.1152/ajprenal.00104.2006
   Harada M, 2015, CIRC J, V79, P495, DOI 10.1253/circj.CJ-15-0138
   Hart RG, 2007, ANN INTERN MED, V146, P857, DOI 10.7326/0003-4819-146-12-200706190-00007
   Hikita M, 2007, INTERNAL MED, V46, P1353, DOI 10.2169/internalmedicine.46.0045
   Hong M, 2020, EUR J CLIN INVEST, V50, DOI 10.1111/eci.13300
   Hu DE, 2004, CANCER RES, V64, P5059, DOI 10.1158/0008-5472.CAN-04-1586
   Huang G, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-30321-z
   Imazio M, 2014, JAMA-J AM MED ASSOC, V312, P1016, DOI 10.1001/jama.2014.11026
   Jia GH, 2015, HYPERTENSION, V65, P531, DOI 10.1161/HYPERTENSIONAHA.114.04737
   Jia L, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0078284
   Kanellis J, 2003, HYPERTENSION, V41, P1287, DOI 10.1161/01.HYP.0000072820.07472.3B
   Kang DH, 2005, J AM SOC NEPHROL, V16, P3553, DOI 10.1681/ASN.2005050572
   Kang DH, 2005, AM J NEPHROL, V25, P425, DOI 10.1159/000087713
   Kang Duk-Hee, 2014, Electrolyte Blood Press, V12, P1, DOI 10.5049/EBP.2014.12.1.1
   Kawasoe S, 2019, CIRC J, V83, P156, DOI 10.1253/circj.CJ-18-0508
   Khosla UM, 2005, KIDNEY INT, V67, P1739, DOI 10.1111/j.1523-1755.2005.00273.x
   Kivity S, 2013, AM J CARDIOL, V111, P1146, DOI 10.1016/j.amjcard.2012.12.034
   Kleber ME, 2015, J AM SOC NEPHROL, V26, P2831, DOI 10.1681/ASN.2014070660
   Korantzopoulos P, 2018, J ARRYTHM, V34, P394, DOI 10.1002/joa3.12077
   Korantzopoulos P, 2018, FREE RADICAL RES, V52, P1199, DOI 10.1080/10715762.2018.1500696
   Kornej J, 2020, CIRC RES, V127, P4, DOI 10.1161/CIRCRESAHA.120.316340
   Kuwabara M, 2017, INT J CARDIOL, V231, P137, DOI 10.1016/j.ijcard.2016.11.268
   Landmesser U, 2007, ARTERIOSCL THROM VAS, V27, P943, DOI 10.1161/01.ATV.0000258415.32883.bf
   Lee TM, 2016, J PHARMACOL SCI, V131, P28, DOI 10.1016/j.jphs.2016.03.009
   Leyva F, 1997, EUR HEART J, V18, P858
   Li J, 2018, HYPERTENSION, V71, P866, DOI 10.1161/HYPERTENSIONAHA.117.10390
   Li SS, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.119.012020
   Li Z, 2018, CELL PHYSIOL BIOCHEM, V45, P1156, DOI 10.1159/000487356
   Li Z, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0147737
   Li ZH, 2016, MOL MED REP, V13, P4343, DOI 10.3892/mmr.2016.5083
   Liang WY, 2016, NUTR METAB CARDIOVAS, V26, P575, DOI 10.1016/j.numecd.2016.03.011
   Lin WD, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-028007
   Lip GYH, 2014, EUR HEART J, V35, P3365, DOI 10.1093/eurheartj/ehu374
   Liu FZ, 2018, INT J CARDIOL, V258, P103, DOI 10.1016/j.ijcard.2018.01.080
   Liu T, 2011, INTERNAL MED, V50, P799, DOI 10.2169/internalmedicine.50.4587
   Liu Yuansheng, 2014, J Atr Fibrillation, V6, P967, DOI 10.4022/jafib.967
   Liu ZT, 2015, SCI REP-UK, V5, DOI 10.1038/srep14325
   MACGOWAN SW, 1995, ANN THORAC SURG, V60, P1289, DOI 10.1016/0003-4975(95)00616-S
   Maharani N, 2015, CIRC J, V79, P2659, DOI 10.1253/circj.CJ-15-0416
   Mantovani A, 2016, J ENDOCRINOL INVEST, V39, P159, DOI 10.1007/s40618-015-0354-z
   Mazzali M, 2001, HYPERTENSION, V38, P1101, DOI 10.1161/hy1101.092839
   Mazzali M, 2001, TRANSPLANTATION, V71, P900, DOI 10.1097/00007890-200104150-00014
   Murakami N, 2017, OPEN HEART, V4, DOI 10.1136/openhrt-2016-000573
   Netea MG, 1997, BLOOD, V89, P577, DOI 10.1182/blood.V89.2.577
   Ogita M, 2016, J CARDIOL, V68, P179, DOI 10.1016/j.jjcc.2015.11.001
   Papageorgiou N, 2017, CARDIOVASC THER, V35, P10, DOI 10.1111/1755-5922.12226
   Peters SAE, 2019, HEART, V105, P226, DOI 10.1136/heartjnl-2018-313630
   Polovina M, 2018, EUR HEART J, V39, P4030, DOI 10.1093/eurheartj/ehy446
   Rabadi MM, 2012, AM J PHYSIOL-RENAL, V302, pF730, DOI 10.1152/ajprenal.00520.2011
   RAO GN, 1991, J BIOL CHEM, V266, P8604
   Sakabe M, 2012, J CARDIOVASC ELECTR, V23, P1130, DOI 10.1111/j.1540-8167.2012.02356.x
   Sautin YY, 2007, AM J PHYSIOL-CELL PH, V293, pC584, DOI 10.1152/ajpcell.00600.2006
   Sawaya SE, 2007, AM J PHYSIOL-HEART C, V292, pH1561, DOI 10.1152/ajpheart.00285.2006
   Shi Y, 2003, NATURE, V425, P516, DOI 10.1038/nature01991
   Singh JA, 2017, ANN RHEUM DIS, V76, P72, DOI 10.1136/annrheumdis-2015-209008
   Song PG, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-22570-9
   Staerk L, 2017, CIRC RES, V120, P1501, DOI 10.1161/CIRCRESAHA.117.309732
   Sun GZ, 2015, BMC CARDIOVASC DISOR, V15, DOI 10.1186/s12872-015-0089-y
   Virdis A, 2020, HYPERTENSION, V75, P302, DOI 10.1161/HYPERTENSIONAHA.119.13643
   Vural Ü, 2019, BMC CARDIOVASC DISOR, V19, DOI 10.1186/s12872-019-1130-3
   Wang Chang-hua, 2005, Zhonghua Xinxueguanbing Zazhi, V33, P522
   Wang DY, 2021, CARDIOVASC TOXICOL, V21, P192, DOI 10.1007/s12012-020-09611-4
   Watanabe S, 2002, HYPERTENSION, V40, P355, DOI 10.1161/01.HYP.0000028589.66335.AA
   Webb R, 2009, AM J MED SCI, V337, P23, DOI 10.1097/MAJ.0b013e31817727af
   Yan ML, 2018, CELL PHYSIOL BIOCHEM, V45, P2122, DOI 10.1159/000488048
   Yang YJ, 2020, LIFE SCI, V259, DOI 10.1016/j.lfs.2020.118290
   Yang YJ, 2018, J AM HEART ASSOC, V7, DOI 10.1161/JAHA.118.008807
   Yang YL, 2019, RENAL FAILURE, V41, P197, DOI 10.1080/0886022X.2019.1591994
   Yu W, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.582680
   Zhang CH, 2016, CELL PHYSIOL BIOCHEM, V38, P1589, DOI 10.1159/000443099
   Zhang JY, 2020, CLIN EXP PHARMACOL P, V47, P1774, DOI 10.1111/1440-1681.13374
   Zhao JP, 2016, INT J CARDIOL, V204, P103, DOI 10.1016/j.ijcard.2015.11.167
   Zharikov S, 2008, AM J PHYSIOL-CELL PH, V295, pC1183, DOI 10.1152/ajpcell.00075.2008
   Zhou Y, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039738
NR 92
TC 51
Z9 55
U1 3
U2 37
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD FEB 26
PY 2021
VL 8
AR 641136
DI 10.3389/fcvm.2021.641136
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA QU9CQ
UT WOS:000627578200001
PM 33718459
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sarkar, P
   Basak, P
   Ghosh, S
   Kundu, M
   Sil, PC
AF Sarkar, Poulami
   Basak, Priyanka
   Ghosh, Sumit
   Kundu, Mousumi
   Sil, Parames C.
TI Prophylactic role of taurine and its derivatives against diabetes
   mellitus and its related complications
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Review
DE Taurine; Diabetes mellitus; Oxidative stress; Diabetic complications;
   Antioxidant; Hypoglycemic effect
ID GLYCATION END-PRODUCTS; NF-KAPPA-B; ENDOPLASMIC-RETICULUM STRESS;
   ATTENUATES OXIDATIVE STRESS; INDUCED HYPERTROPHIC GROWTH; INDUCED
   INSULIN-SECRETION; HIGH-GLUCOSE; TAUROURSODEOXYCHOLIC ACID;
   NITRIC-OXIDE; BILE-ACID
AB Taurine is a conditionally essential amino acid present in the body in free form. Mammalian taurine is synthesized in the pancreas via the cysteine sulfinic acid pathway. Anti-oxidation and anti-inflammation are two main properties through which it exerts its therapeutic effects. Many studies have shown its excellent therapeutic potential against diabetes mellitus and related complications like diabetic neuropathy, retinopathy, nephropathy, hematological dysfunctions, reproductive dysfunctions, liver and pancreas related complications etc. Not only taurine, a number of its derivatives have also been reported to be important in ameliorating diabetic complications. The present review has been aimed to describe the importance of taurine and its derivatives against diabetic metabolic syndrome and related complications.
C1 [Sarkar, Poulami; Basak, Priyanka; Ghosh, Sumit; Kundu, Mousumi; Sil, Parames C.] Bose Inst, Div Mol Med, P-1-12,CIT Scheme 7 M, Kolkata 700054, W Bengal, India.
C3 Department of Science & Technology (India); Bose Institute
RP Sil, PC (corresponding author), Bose Inst, Div Mol Med, P-1-12,CIT Scheme 7 M, Kolkata 700054, W Bengal, India.
EM parames@jcbose.ac.in
RI Sarkar, Poulami/KIC-9599-2024; Das, Joydeep/AAE-3501-2021; Ghosh,
   Sumit/MIQ-3051-2025
OI Ghosh, Sumit/0000-0002-9199-5941; Sarkar, Poulami/0009-0001-2874-0575
CR Abd El-Twab SM, 2016, CAN J PHYSIOL PHARM, V94, P651, DOI 10.1139/cjpp-2015-0503
   Agca CA, 2014, FOOD CHEM TOXICOL, V71, P116, DOI 10.1016/j.fct.2014.05.023
   Ahn T, 2006, TOXICOL LETT, V166, P27, DOI 10.1016/j.toxlet.2006.05.009
   Aichler M, 2017, CELL METAB, V25, P1334, DOI 10.1016/j.cmet.2017.04.012
   Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
   [Anonymous], 2016, ISBN, V978, P88
   Arany E, 2004, DIABETOLOGIA, V47, P1831, DOI 10.1007/s00125-004-1535-z
   Askwith T, 2012, EXP NEUROL, V233, P154, DOI 10.1016/j.expneurol.2011.09.010
   Askwith T, 2009, AM J PHYSIOL-ENDOC M, V297, pE620, DOI 10.1152/ajpendo.00287.2009
   ATLAS M, 1984, J MOL CELL CARDIOL, V16, P311, DOI 10.1016/S0022-2828(84)80602-1
   BARDE YA, 1989, NEURON, V2, P1525, DOI 10.1016/0896-6273(89)90040-8
   Bhattacharya S, 2013, FOOD CHEM TOXICOL, V60, P328, DOI 10.1016/j.fct.2013.07.051
   Bianchi L, 2012, AMINO ACIDS, V42, P2267, DOI 10.1007/s00726-011-0968-1
   Bolzán AD, 2002, MUTAT RES-REV MUTAT, V512, P121, DOI 10.1016/S1383-5742(02)00044-3
   Brons C, 2004, EUR J CLIN NUTR, V58, P1239, DOI 10.1038/sj.ejcn.1601955
   Budhram R, 2013, ADV EXP MED BIOL, V775, P321, DOI 10.1007/978-1-4614-6130-2_27
   Bulley S, 2013, J PHYSIOL-LONDON, V591, P123, DOI 10.1113/jphysiol.2012.243147
   Caletti G, 2015, BEHAV BRAIN RES, V283, P11, DOI 10.1016/j.bbr.2015.01.018
   Caletti G, 2012, AMINO ACIDS, V43, P1525, DOI 10.1007/s00726-012-1226-x
   Camargo RL, 2013, ADV EXP MED BIOL, V776, P93, DOI 10.1007/978-1-4614-6093-0_10
   Cappelli AP, 2014, LIVER INT, V34, P771, DOI 10.1111/liv.12291
   Carneiro EA, 2009, J NUTR BIOCHEM, V20, P503, DOI 10.1016/j.jnutbio.2008.05.008
   Caro AA, 2004, ANNU REV PHARMACOL, V44, P27, DOI 10.1146/annurev.pharmtox.44.101802.121704
   Chauncey KB, 2003, ADV EXP MED BIOL, V526, P91
   Chen K, 2009, BRAIN RES, V1279, P131, DOI 10.1016/j.brainres.2009.04.054
   Chen W, 2016, FOOD FUNCT, V7, P1849, DOI [10.1039/c5fo01295c, 10.1039/C5FO01295C]
   Chen Y, 2008, AM J NEPHROL, V28, P1014, DOI 10.1159/000148209
   Chowdhury S, 2016, BIOFACTORS, V42, P647, DOI 10.1002/biof.1301
   Chowdhury S, 2016, FOOD CHEM TOXICOL, V97, P187, DOI 10.1016/j.fct.2016.09.011
   CONTRERAS E, 1984, ARCH INT PHARMACOD T, V267, P224
   da-Silva WS, 2011, FEBS LETT, V585, P539, DOI 10.1016/j.febslet.2010.12.044
   Dalaklioglu S, 2014, FUND CLIN PHARMACOL, V28, P394, DOI 10.1111/fcp.12041
   Das J, 2012, FOOD FUNCT, V3, P1251, DOI 10.1039/c2fo30117b
   Das J, 2012, AMINO ACIDS, V43, P1509, DOI 10.1007/s00726-012-1225-y
   Das J, 2012, AMINO ACIDS, V42, P1839, DOI 10.1007/s00726-011-0904-4
   Das J, 2012, TOXICOL APPL PHARM, V258, P296, DOI 10.1016/j.taap.2011.11.009
   Das J, 2011, BIOCHEM PHARMACOL, V81, P891, DOI 10.1016/j.bcp.2011.01.008
   Das J, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012602
   Das J, 2010, TOXICOLOGY, V269, P24, DOI 10.1016/j.tox.2010.01.003
   Das J, 2010, FREE RADICAL RES, V44, P340, DOI 10.3109/10715760903513017
   Das J, 2009, TOXICOL LETT, V187, P201, DOI 10.1016/j.toxlet.2009.03.001
   Das Joydeep, 2008, Pathophysiology, V15, P181, DOI 10.1016/j.pathophys.2008.06.002
   Das J, 2009, DRUG CHEM TOXICOL, V32, P93, DOI 10.1080/01480540802564171
   de la Puerta C, 2010, NUTR HOSP, V25, P910, DOI 10.3305/nh.2010.25.6.4815
   Di Leo MAS, 2003, FREE RADICAL RES, V37, P323, DOI 10.1080/1071576021000055271
   Di Leo MAS, 2002, AMINO ACIDS, V23, P401, DOI 10.1007/s00726-002-0202-2
   Duan LJ, 2017, BIOCHEM BIOPH RES CO, V484, P598, DOI 10.1016/j.bbrc.2017.01.145
   Duman RS, 2014, DEPRESS ANXIETY, V31, P291, DOI 10.1002/da.22227
   DUMOULIN JCM, 1992, J REPROD FERTIL, V94, P373, DOI 10.1530/jrf.0.0940373
   Ejdesjö A, 2012, AM J PHYSIOL-ENDOC M, V302, pE1198, DOI 10.1152/ajpendo.00661.2011
   El Ashry FEZ, 2012, FOOD CHEM TOXICOL, V50, P1159, DOI 10.1016/j.fct.2011.12.020
   El Idrissi A, 2008, NEUROSCIENCE, V156, P693, DOI 10.1016/j.neuroscience.2008.07.055
   El Idrissi A, 2009, ADV EXP MED BIOL, V643, P353, DOI 10.1007/978-0-387-75681-3_36
   El Mesallamy HO, 2010, DIABETOL METAB SYNDR, V2, DOI 10.1186/1758-5996-2-46
   El-Batch M, 2011, J AGR FOOD CHEM, V59, P4995, DOI 10.1021/jf1049547
   El-Serag HB, 2004, GASTROENTEROLOGY, V126, P460, DOI 10.1053/j.gastro.2003.10.065
   Fernández-Sánchez L, 2011, INVEST OPHTH VIS SCI, V52, P4998, DOI 10.1167/iovs.11-7496
   Figueroa ALC, 2016, SCI REP-UK, V6, DOI 10.1038/srep36801
   Foda D., 2016, J App Pharm Sci, V6, P045, DOI [10.7324/JAPS.2016.601006, DOI 10.7324/JAPS.2016.601006]
   Forbes JM, 2008, DIABETES, V57, P1446, DOI 10.2337/db08-0057
   Forbes JM, 2013, PHYSIOL REV, V93, P137, DOI 10.1152/physrev.00045.2011
   Forbes JM, 2012, AMINO ACIDS, V42, P1185, DOI 10.1007/s00726-010-0771-4
   Franconi F, 2004, NEUROCHEM RES, V29, P143, DOI 10.1023/B:NERE.0000010443.05899.2f
   Froger N, 2013, ADV EXP MED BIOL, V775, P69, DOI 10.1007/978-1-4614-6130-2_6
   Gaspar JM, 2013, NEUROSCIENCE, V253, P380, DOI 10.1016/j.neuroscience.2013.08.053
   Ghosh J, 2009, TOXICOL APPL PHARM, V240, P73, DOI 10.1016/j.taap.2009.07.008
   Ghosh M, 2014, TOXICOL RES-UK, V3, P474, DOI 10.1039/c4tx00030g
   Ghosh S, 2015, TOXICOL REP, V2, P365, DOI 10.1016/j.toxrep.2014.12.017
   Ghosh S, 2015, FOOD CHEM TOXICOL, V83, P111, DOI 10.1016/j.fct.2015.05.022
   Ghosh S, 2017, FOOD CHEM TOXICOL, V103, P41, DOI 10.1016/j.fct.2017.02.028
   Gossai D, 2009, ADV EXP MED BIOL, V643, P359, DOI 10.1007/978-0-387-75681-3_37
   Han XB, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0117718
   hang J., 2002, Advances in Experimental Medicine Biology, V483, P571
   Hansen SH, 2001, DIABETES-METAB RES, V17, P330, DOI 10.1002/dmrr.229
   Hara K, 2012, AMINO ACIDS, V43, P397, DOI 10.1007/s00726-011-1094-9
   Hatori M, 2012, CELL METAB, V15, P848, DOI 10.1016/j.cmet.2012.04.019
   He M, 2014, ACTA BIOCH BIOPH SIN, V46, P426, DOI 10.1093/abbs/gmu008
   Higo Satomi, 2008, Kobe J Med Sci, V54, pE35
   Hosseini A, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/168039
   Hsu YW, 2012, EXP EYE RES, V103, P71, DOI 10.1016/j.exer.2012.08.001
   Huang JS, 2007, AM J PHYSIOL-RENAL, V293, pF1072, DOI 10.1152/ajprenal.00020.2007
   Huang JS, 2009, TOXICOL SCI, V111, P109, DOI 10.1093/toxsci/kfp134
   Huang JS, 2008, TOXICOL APPL PHARM, V233, P220, DOI 10.1016/j.taap.2008.09.002
   HUXTABLE RJ, 1992, PHYSIOL REV, V72, P101, DOI 10.1152/physrev.1992.72.1.101
   Imae M, 2014, AMINO ACIDS, V46, P81, DOI 10.1007/s00726-012-1434-4
   Ito T, 2015, J PHARMACOL SCI, V129, P59, DOI 10.1016/j.jphs.2015.08.007
   Ito T, 2012, AMINO ACIDS, V42, P1529, DOI 10.1007/s00726-011-0883-5
   JACOBSEN JG, 1968, PHYSIOL REV, V48, P424, DOI 10.1152/physrev.1968.48.2.424
   Jong CJ, 2012, AMINO ACIDS, V42, P2223, DOI 10.1007/s00726-011-0962-7
   Jurkowska H, 2015, AMINO ACIDS, V47, P1215, DOI 10.1007/s00726-015-1948-7
   Kamata K, 1996, EUR J PHARMACOL, V303, P47, DOI 10.1016/0014-2999(96)00094-5
   Kenny C, 2014, PRIM CARE DIABETES, V8, P3, DOI 10.1016/j.pcd.2013.09.002
   Kertes PJ., 2007, Evidence based eye care
   Kim KS, 2012, EXP MOL MED, V44, P665, DOI 10.3858/emm.2012.44.11.075
   Kim SJ, 2007, CURR DIABETES REV, V3, P165, DOI 10.2174/157339907781368940
   Kitabchi AE, 2009, DIABETES CARE, V32, P1335, DOI 10.2337/dc09-9032
   Kume E, 2004, EXP TOXICOL PATHOL, V55, P467, DOI 10.1078/0940-2993-00351
   L'Amoreaux WJ, 2010, J BIOMED SCI, V17, DOI 10.1186/1423-0127-17-S1-S14
   Lambert P., 2002, Medicine, V30, P1, DOI [DOI 10.1383/MEDC.30.1.1.28264, 10.1383/medc.30.1.1.28264]
   LAMPSON WG, 1983, CAN J PHYSIOL PHARM, V61, P457, DOI 10.1139/y83-070
   Larsen LH, 2013, ADV EXP MED BIOL, V776, P39, DOI 10.1007/978-1-4614-6093-0_5
   Lee EA, 2005, KIDNEY INT, V67, P1762, DOI 10.1111/j.1523-1755.2005.00274.x
   Lee IO, 2010, ACTA PHARMACOL SIN, V31, P907, DOI 10.1038/aps.2010.82
   Li F, 2005, AM J PHYSIOL-ENDOC M, V288, pE29, DOI 10.1152/ajpendo.00168.2004
   Li F, 2006, NEUROBIOL DIS, V22, P669, DOI 10.1016/j.nbd.2006.01.012
   Lieber CS, 1997, PHYSIOL REV, V77, P517, DOI 10.1152/physrev.1997.77.2.517
   Lin SM, 2010, J BIOMED SCI, V17, DOI 10.1186/1423-0127-17-S1-S46
   Liu Y, 2002, IMMUNOL LETT, V80, P27, DOI 10.1016/S0165-2478(01)00291-7
   Lodish H., 1995, MOL CELL BIOL, V3
   Manna P, 2012, BIOCHIMIE, V94, P786, DOI 10.1016/j.biochi.2011.11.010
   Manna P, 2010, FREE RADICAL BIO MED, V48, P1465, DOI 10.1016/j.freeradbiomed.2010.02.025
   Manna P, 2010, TOXICOL APPL PHARM, V244, P114, DOI 10.1016/j.taap.2009.12.024
   Manna P, 2009, CHEM-BIOL INTERACT, V181, P297, DOI 10.1016/j.cbi.2009.08.004
   Manna P, 2009, TOXICOLOGY, V257, P53, DOI 10.1016/j.tox.2008.12.008
   Mantopoulos D, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024245
   Mao Dong-wei, 2004, Zhonghua Fu Chan Ke Za Zhi, V39, P169
   Mathavan S, 2017, EUR J PHARM SCI, V106, P1, DOI 10.1016/j.ejps.2017.05.041
   Mathavan S, 2016, DRUG DELIV, V23, P2869, DOI 10.3109/10717544.2015.1110846
   Mathew E, 2013, ADV EXP MED BIOL, V775, P345, DOI 10.1007/978-1-4614-6130-2_28
   MATURO J, 1988, BIOCHEM PHARMACOL, V37, P3755, DOI 10.1016/0006-2952(88)90411-X
   McCarty M.F., 2017, SUPPLEMENTATION PHYC, P15
   Mochizuki H, 1998, BIOSCI BIOTECH BIOCH, V62, P578, DOI 10.1271/bbb.62.578
   Mohamed N., 2016, LJSR, V5, P1
   Mohamed NA., 2017, BENI SUEF U J BASIC, V6, P247, DOI [10.1016/j.bjbas.2017.04.006, DOI 10.1016/J.BJBAS.2017.04.006]
   Moloney MA, 2010, DIABETES VASC DIS RE, V7, P300, DOI 10.1177/1479164110375971
   Mooranian A, 2015, DRUG DELIV TRANSL RE, V5, P511, DOI 10.1007/s13346-015-0248-9
   Nandhini TA, 2003, CLIN CHIM ACTA, V336, P129, DOI 10.1016/S0009-8981(03)00337-1
   Napoli Z, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/7313162
   Obrosova IG, 1999, INVEST OPHTH VIS SCI, V40, P680
   OGASAWARA M, 1993, CHEM PHARM BULL, V41, P2172
   Oja Simo S, 2007, Proc West Pharmacol Soc, V50, P8
   Oudit GY, 2004, CIRCULATION, V109, P1877, DOI 10.1161/01.CIR.0000124229.40424.80
   Oveson BC, 2011, J NEUROCHEM, V116, P144, DOI 10.1111/j.1471-4159.2010.07092.x
   Pal Pabitra Bikash, 2014, PLoS One, V9, pe107220, DOI 10.1371/journal.pone.0107220
   Pandya KG, 2015, ADV EXP MED BIOL, V803, P227, DOI 10.1007/978-3-319-15126-7_20
   Pandya KG, 2013, ADV EXP MED BIOL, V775, P371, DOI 10.1007/978-1-4614-6130-2_29
   PARK E, 1993, J LEUKOCYTE BIOL, V54, P119, DOI 10.1002/jlb.54.2.119
   Park EJ, 2004, BIOCHEM PHARMACOL, V67, P1089, DOI 10.1016/j.bcp.2003.11.003
   Pase M.P., 2010, AM J CLIN NUTR
   Patel SN, 2016, EXP TOXICOL PATHOL, V68, P103, DOI 10.1016/j.etp.2015.11.002
   Phillips MJ, 2008, INVEST OPHTH VIS SCI, V49, P2148, DOI 10.1167/iovs.07-1012
   Pop-Busui R, 2001, EXP NEUROL, V168, P259, DOI 10.1006/exnr.2000.7591
   Rahmeier FL, 2016, NEUROSCI LETT, V630, P84, DOI 10.1016/j.neulet.2016.07.032
   Rashi K, 2017, BIOCHEM PHARMACOL, V143, P140, DOI 10.1016/j.bcp.2017.07.009
   Rashid K, 2015, TOXICOL APPL PHARM, V282, P297, DOI 10.1016/j.taap.2014.12.003
   Rashid K, 2015, BBA-MOL BASIS DIS, V1852, P70, DOI 10.1016/j.bbadis.2014.11.007
   Rashid K, 2013, FOOD CHEM TOXICOL, V51, P317, DOI 10.1016/j.fct.2012.10.007
   Ribeiro RA, 2009, DIABETES-METAB RES, V25, P370, DOI 10.1002/dmrr.959
   Ribeiro RA, 2012, AMINO ACIDS, V43, P1791, DOI 10.1007/s00726-012-1263-5
   Ripps H, 2012, MOL VIS, V18, P2673
   Ruan YJ, 2016, J SEX MED, V13, P778, DOI 10.1016/j.jsxm.2016.02.164
   Santos-Silva JC, 2015, AMINO ACIDS, V47, P1533, DOI 10.1007/s00726-015-1988-z
   Sarwar N, 2010, LANCET, V375, P2215, DOI 10.1016/s0140-6736(10)60484-9
   Schmidt HD, 2010, NEUROPSYCHOPHARMACOL, V35, P2378, DOI 10.1038/npp.2010.114
   Shivananjappa MM, 2012, REPROD BIOMED ONLINE, V24, P558, DOI 10.1016/j.rbmo.2012.01.016
   Shrilatha B, 2007, REPROD TOXICOL, V23, P578, DOI 10.1016/j.reprotox.2007.02.001
   Simmons RA, 2006, FREE RADICAL BIO MED, V40, P917, DOI 10.1016/j.freeradbiomed.2005.12.018
   Sinha M, 2008, BMB REP, V41, P657, DOI 10.5483/BMBRep.2008.41.9.657
   Sirdah MM, 2015, DIAB MET SYND CLIN R, V9, P55, DOI 10.1016/j.dsx.2014.05.001
   Solon CS, 2012, AMINO ACIDS, V42, P2403, DOI 10.1007/s00726-011-1045-5
   Son HY, 2007, J NUTR SCI VITAMINOL, V53, P324, DOI 10.3177/jnsv.53.324
   Song M., 2012, EVID BASED COMPLEMEN
   Stapleton PP, 1998, JPEN-PARENTER ENTER, V22, P42, DOI 10.1177/014860719802200142
   STEVENS MJ, 1993, DIABETOLOGIA, V36, P608, DOI 10.1007/BF00404069
   Tappia PS, 2013, PHYSIOL RES, V62, P171, DOI 10.33549/physiolres.932388
   Tas S, 2007, ARCH MED RES, V38, P276, DOI 10.1016/j.arcmed.2006.09.018
   Terada T, 2011, CAN J ANESTH, V58, P630, DOI 10.1007/s12630-011-9504-8
   Thadani JM., 2017, J Case Rep, V7, P235, DOI [10.17659/01.2017.0064, DOI 10.17659/01.2017.0064]
   TRACHTMAN H, 1995, AM J PHYSIOL-RENAL, V269, pF429, DOI 10.1152/ajprenal.1995.269.3.F429
   Tripathi BK, 2006, MED SCI MONITOR, V12, pRA130
   Tsounapi P., 2017, ANDROLOGIA
   Tsounapi P, 2012, MOL CELL BIOCHEM, V369, P195, DOI 10.1007/s11010-012-1382-z
   Tuomi T, 2014, LANCET, V383, P1084, DOI 10.1016/S0140-6736(13)62219-9
   Ulrich-Merzenich G, 2007, EUR J NUTR, V46, P431, DOI 10.1007/s00394-007-0682-7
   Verrotti A, 2012, EUR J ENDOCRINOL, V167, P749, DOI 10.1530/EJE-12-0699
   Verzola D, 2002, J INVEST MED, V50, P443, DOI 10.1136/jim-50-06-04
   Vettorazzi JF, 2016, METABOLISM, V65, P54, DOI 10.1016/j.metabol.2015.10.021
   Vilchis C, 1996, NEUROCHEM RES, V21, P1167, DOI 10.1007/BF02532391
   Wang CF, 2016, J ETHNOPHARMACOL, V185, P162, DOI 10.1016/j.jep.2016.03.026
   Wang GG, 2013, CROAT MED J, V54, P171, DOI 10.3325/cmj.2013.54.171
   Wang LJ, 2008, EUR J PHARMACOL, V597, P75, DOI 10.1016/j.ejphar.2008.08.031
   Wang LJ, 2008, RENAL FAILURE, V30, P763, DOI 10.1080/08860220802272563
   WEISS RB, 1982, CANCER TREAT REP, V66, P427
   Winiarska K, 2009, BIOCHIMIE, V91, P261, DOI 10.1016/j.biochi.2008.09.006
   Wolf G, 2004, EUR J CLIN INVEST, V34, P785, DOI 10.1111/j.1365-2362.2004.01429.x
   Wu CW, 2010, J GASTROEN HEPATOL, V25, P1019, DOI 10.1111/j.1440-1746.2010.06279.x
   Wu N, 2010, DIABETES RES CLIN PR, V90, P288, DOI 10.1016/j.diabres.2010.08.020
   Xiao C, 2008, DIABETOLOGIA, V51, P139, DOI 10.1007/s00125-007-0859-x
   YANG CS, 1990, DRUG METAB REV, V22, P147, DOI 10.3109/03602539009041082
   Yao HT, 2009, FOOD CHEM TOXICOL, V47, P1703, DOI 10.1016/j.fct.2009.04.030
   Zeng KH, 2010, MOL CELL NEUROSCI, V45, P192, DOI 10.1016/j.mcn.2010.06.010
   Zeng KH, 2009, NEUROCHEM RES, V34, P244, DOI 10.1007/s11064-008-9763-0
   Zhang J, 2016, NUTRIENTS, V8, DOI 10.3390/nu8100589
   Zhang LX, 2000, CURR EYE RES, V20, P131, DOI 10.1076/0271-3683(200002)20:2;1-D;FT131
   Zhao YT, 2016, INT J MOL MED, V38, P659, DOI 10.3892/ijmm.2016.2645
   Zhou Q, 2016, BIOL TRACE ELEM RES, V170, P348, DOI 10.1007/s12011-015-0474-5
   Zhu Q, 2013, EXP CLIN ENDOCR DIAB, V121, P43, DOI 10.1055/s-0032-1321787
NR 197
TC 51
Z9 52
U1 0
U2 23
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD DEC
PY 2017
VL 110
BP 109
EP 121
DI 10.1016/j.fct.2017.10.022
PG 13
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA FQ2TU
UT WOS:000418211700011
PM 29050977
DA 2025-06-11
ER

PT J
AU Serafini, M
   Peluso, I
AF Serafini, Mauro
   Peluso, Ilaria
TI Functional Foods for Health: The Interrelated Antioxidant and
   Anti-Inflammatory Role of Fruits, Vegetables, Herbs, Spices and Cocoa in
   Humans
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Antioxidants; human; functional foods; inflammation; oxidative stress;
   plant foods
ID C-REACTIVE PROTEIN; GREEN TEA EXTRACT; NF-KAPPA-B; CARDIOVASCULAR
   RISK-FACTORS; RANDOMIZED CONTROLLED-TRIAL; TYPE-2 DIABETES-MELLITUS;
   PLACEBO-CONTROLLED TRIAL; GRAPE SEED EXTRACT; OXIDATIVE STRESS;
   METABOLIC SYNDROME
AB The health benefits of plant food-based diets could be related to both integrated antioxidant and antiinflammatory mechanisms exerted by a wide array of phytochemicals present in fruit, vegetables, herbs and spices. Therefore, there is mounting interest in identifying foods, food extracts and phytochemical formulations from plant sources which are able to efficiently modulate oxidative and inflammatory stress to prevent diet-related diseases. This paper reviews available evidence about the effect of supplementation with selected fruits, vegetables, herbs, spices and their extracts or galenic formulation on combined markers of redox and inflammatory status in humans.
C1 [Serafini, Mauro; Peluso, Ilaria] Council Agr Res & Econ, Ctr Food & Nutr, Funct Foods & Metab Stress Prevent Lab, Via Ardeatina 546, I-00176 Rome, Italy.
C3 Consiglio per la Ricerca in Agricoltura e L'analisi Dell'economia
   Agraria (CREA)
RP Serafini, M (corresponding author), Council Agr Res & Econ, Ctr Food & Nutr, Funct Foods & Metab Stress Prevent Lab, Via Ardeatina 546, I-00176 Rome, Italy.
EM serafini_mauro@yahoo.it
RI Peluso, Ilaria/ABE-3399-2021; Serafini, Mauro/K-6498-2018; Peluso,
   Ilaria/A-8023-2018
OI Serafini, Mauro/0000-0003-0913-936X; Peluso, Ilaria/0000-0002-6210-5241
FU PGT Healthcare
FX Editorial assistance was provided by Luca Giacomelli, PhD, on behalf of
   Content Ed Net; this assistance was funded by PGT Healthcare.
CR [Anonymous], 2012, EVID-BASED COMPL ALT
   [Anonymous], AGING
   [Anonymous], 2017, EUR J CLIN NUTR, DOI DOI 10.1038/ejcn.2016.151
   [Anonymous], 2015, NUTRITION, DOI DOI 10.1016/j.nut.2014.11.020
   [Anonymous], HERBAL MED BIOMOLECU
   Bakker GCM, 2010, AM J CLIN NUTR, V91, P1044, DOI 10.3945/ajcn.2009.28822
   Balogun E, 2003, BIOCHEM J, V371, P887, DOI 10.1042/BJ20021619
   Barona J, 2012, NUTRIENTS, V4, P1945, DOI 10.3390/nu4121945
   Basu A, 2013, J NUTR METAB, V2013, DOI 10.1155/2013/708381
   Basu A, 2014, J NUTR, V144, P830, DOI 10.3945/jn.113.188169
   Basu A, 2011, NUTR RES, V31, P190, DOI 10.1016/j.nutres.2011.02.003
   Basu A, 2009, NUTR J, V8, DOI 10.1186/1475-2891-8-43
   Bogdanski P, 2012, NUTR RES, V32, P421, DOI 10.1016/j.nutres.2012.05.007
   Bower A, 2016, CRIT REV FOOD SCI, V56, P2728, DOI 10.1080/10408398.2013.805713
   Braga M, 2012, NUTRITION, V28, P160, DOI 10.1016/j.nut.2011.05.014
   Burton-Freeman B, 2010, BRIT J NUTR, V104, pS1, DOI 10.1017/S0007114510003909
   Calo LA, 2014, CLIN NUTR, V33, P437, DOI 10.1016/j.clnu.2013.06.010
   Castilla P, 2008, AM J CLIN NUTR, V87, P1053, DOI 10.1093/ajcn/87.4.1053
   Castilla P, 2006, AM J CLIN NUTR, V84, P252, DOI 10.1093/ajcn/84.1.252
   Cichocki M, 2010, TOXICOLOGY, V268, P118, DOI 10.1016/j.tox.2009.12.013
   Clifton PM, 2004, J BIOMED BIOTECHNOL, P272, DOI 10.1155/S1110724304403088
   Simao TNC, 2013, BRIT J NUTR, V110, P1885, DOI 10.1017/S0007114513001207
   Copple IM, 2014, TOXICOL SCI, V140, P462, DOI 10.1093/toxsci/kfu080
   Delui MH, 2013, INT J PREVENTIVE MED, V4, P1045
   Denniss SG, 2008, VASC HEALTH RISK MAN, V4, P213, DOI 10.2147/vhrm.2008.04.01.213
   Deopurkar R, 2010, DIABETES CARE, V33, P991, DOI 10.2337/dc09-1630
   Dickerson R, 2015, ANTIOXID REDOX SIGN, V22, P339, DOI 10.1089/ars.2014.6138
   DiSilvestro RA, 2012, NUTR J, V11, DOI 10.1186/1475-2891-11-79
   Dow CA, 2013, J NUTR, V143, P1586, DOI 10.3945/jn.113.175166
   Drobnic F, 2014, J INT SOC SPORT NUTR, V11, DOI 10.1186/1550-2783-11-31
   Drummond Elaine M., 2013, Journal of Dietary Supplements, V10, P370, DOI 10.3109/19390211.2013.830680
   Eichenberger P, 2010, INT J VITAM NUTR RES, V80, P54, DOI 10.1024/0300-9831/a000006
   Georgiev V, 2014, NUTRIENTS, V6, P391, DOI 10.3390/nu6010391
   Ghosh S, 2015, FOOD CHEM TOXICOL, V83, P111, DOI 10.1016/j.fct.2015.05.022
   Goya L, 2016, NUTRIENTS, V8, DOI 10.3390/nu8040212
   Guarner V, 2015, INTERD T GERONT GERI, V40, P99, DOI 10.1159/000364934
   Gupta H, 2012, PHYTOTHER RES, V26, P265, DOI 10.1002/ptr.3542
   HALLIWELL B, 1994, ENVIRON HEALTH PERSP, V102, P5, DOI 10.2307/3432205
   Han KH, 2016, WORLD J GASTROENTERO, V22, P37, DOI 10.3748/wjg.v22.i1.37
   Hatipoglu M, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0128134
   Hokayem M, 2013, DIABETES CARE, V36, P1454, DOI 10.2337/dc12-1652
   Hosseini B, 2016, COMPLEMENT THER CLIN, V22, P44, DOI 10.1016/j.ctcp.2015.12.003
   Hou CW, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0116387
   Hsu SP, 2007, AM J CLIN NUTR, V86, P1539, DOI 10.1093/ajcn/86.5.1539
   Hu R, 2010, ANTIOXID REDOX SIGN, V13, P1679, DOI 10.1089/ars.2010.3276
   Ishii T, 2009, CHEM RES TOXICOL, V22, P1689, DOI 10.1021/tx900148k
   Jantan I, 2015, FRONT PLANT SCI, V6, DOI 10.3389/fpls.2015.00655
   Jensen GS, 2011, J MED FOOD, V14, P702, DOI 10.1089/jmf.2010.0150
   Jin Y, 2010, MOL NUTR FOOD RES, V54, P1506, DOI 10.1002/mnfr.200900579
   Kar P, 2009, DIABETIC MED, V26, P526, DOI 10.1111/j.1464-5491.2009.02727.x
   Karlsen A, 2010, EUR J NUTR, V49, P345, DOI 10.1007/s00394-010-0092-0
   Kolodziejczyk-Czepas J, 2015, INT J BIOL MACROMOL, V72, P1152, DOI 10.1016/j.ijbiomac.2014.09.032
   Koujan SE, 2015, PHYTOMEDICINE, V22, P290, DOI 10.1016/j.phymed.2014.12.010
   Kumar S., 2015, British Journal of Medicine and Medical Research, V7, P438
   Lamprecht M, 2013, BRIT J NUTR, V110, P1685, DOI 10.1017/S0007114513001001
   Lerman Robert H, 2014, Glob Adv Health Med, V3, P34, DOI 10.7453/gahmj.2013.098
   Lettieri-Barbato D, 2013, BRIT J NUTR, V109, P1544, DOI 10.1017/S0007114513000263
   Li YF, 2015, NUTRITION, V31, P691, DOI 10.1016/j.nut.2014.11.008
   Magrone T, 2013, CAN J PHYSIOL PHARM, V91, P387, DOI 10.1139/cjpp-2012-0307
   Magrone T, 2012, CURR PHARM DESIGN, V18, P1609, DOI 10.2174/138161212799958512
   Mahmoodpoor A, 2010, DARU, V18, P23
   Markovits N, 2009, ISR MED ASSOC J, V11, P598
   Marotta F, 2007, ANN NY ACAD SCI, V1119, P196, DOI 10.1196/annals.1404.011
   Marotta F, 2011, J BIOL REG HOMEOS AG, V25, P37
   Marotta F, 2007, J GASTROEN HEPATOL, V22, P697, DOI 10.1111/j.1440-1746.2007.04937.x
   Martinez-López S, 2014, FOOD FUNCT, V5, P364, DOI 10.1039/c3fo60352k
   Mashhadi NS, 2013, INT J PREVENTIVE MED, V4, pS1
   Mathur S, 2002, J NUTR, V132, P3663, DOI 10.1093/jn/132.12.3663
   Mellen PB, 2010, J AM COLL NUTR, V29, P469, DOI 10.1080/07315724.2010.10719883
   Miglio C, 2014, BRIT J NUTR, V111, P294, DOI 10.1017/S0007114513002407
   Moazen S, 2013, ANN NUTR METAB, V63, P256, DOI 10.1159/000356053
   Morabito G, 2015, ENDOCR METAB IMMUNE, V15, P46, DOI 10.2174/1871530314666141021114325
   Mulero J, 2012, CLIN NUTR, V31, P372, DOI 10.1016/j.clnu.2011.11.014
   Nair S, 2007, ACTA PHARMACOL SIN, V28, P459, DOI 10.1111/j.1745-7254.2007.00549.x
   Namazi N, 2012, Pak J Biol Sci, V15, P98, DOI 10.3923/pjbs.2012.98.102
   Namazi N, 2011, Pak J Biol Sci, V14, P775, DOI 10.3923/pjbs.2011.775.779
   Nemzer BV, 2011, NUTR J, V10, DOI 10.1186/1475-2891-10-67
   Nieman DC, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0072215
   Nieman DC, 2012, PLANT FOOD HUM NUTR, V67, P415, DOI 10.1007/s11130-012-0325-x
   Opara EI, 2014, INT J MOL SCI, V15, P19183, DOI 10.3390/ijms151019183
   Panahi Y, 2015, CLIN NUTR, V34, P1101, DOI 10.1016/j.clnu.2014.12.019
   Pellegrini N, 2003, J NUTR, V133, P2812, DOI 10.1093/jn/133.9.2812
   Pellegrini N, 2006, MOL NUTR FOOD RES, V50, P1030, DOI 10.1002/mnfr.200600067
   Peluso I, 2015, CRIT REV FOOD SCI, V55, P383, DOI 10.1080/10408398.2012.656770
   Peluso I, 2012, CURR PHARM DESIGN, V18, P85, DOI 10.2174/138161212798919020
   Petrosino T, 2014, CRIT REV FOOD SCI, V54, P1202, DOI 10.1080/10408398.2011.630153
   Potter AS, 2011, NUTR J, V10, DOI 10.1186/1475-2891-10-96
   Riso P, 2006, J AGR FOOD CHEM, V54, P2563, DOI 10.1021/jf053033c
   Rivara MB, 2015, J RENAL NUTR, V25, P40, DOI 10.1053/j.jrn.2014.07.006
   Sarriá B, 2014, BRIT J NUTR, V111, P122, DOI 10.1017/S000711451300202X
   Selvi NMK, 2015, INDIAN J CLIN BIOCHE, V30, P180, DOI 10.1007/s12291-014-0436-2
   Serafini M, 2011, CURR TOP MED CHEM, V11, P1821, DOI 10.2174/156802611796235125
   Serafini M, 2010, P NUTR SOC, V69, P273, DOI 10.1017/S002966511000162X
   Serban C, 2015, NUTRITION, V31, P1061, DOI 10.1016/j.nut.2015.02.004
   Shariatpanahi ZV, 2013, J CRIT CARE, V28, DOI 10.1016/j.jcrc.2012.04.017
   Shema-Didi L, 2013, NUTR RES, V33, P442, DOI 10.1016/j.nutres.2013.04.004
   Shema-Didi L, 2012, FREE RADICAL BIO MED, V53, P297, DOI 10.1016/j.freeradbiomed.2012.05.013
   Shidfar Farzad, 2015, J Complement Integr Med, V12, P165, DOI 10.1515/jcim-2014-0021
   Shishehbor F, 2016, INT J ENDOCRINOL MET, V14, DOI 10.5812/ijem.33835
   Shukla SD, 2012, FRONT NEUROSCI-SWITZ, V6, DOI 10.3389/fnins.2012.00112
   Silva RO, 2015, J PHARM PHARMACOL, V67, P1017, DOI 10.1111/jphp.12399
   Sirota R, 2015, REDOX BIOL, V4, P48, DOI 10.1016/j.redox.2014.11.012
   Solà R, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031103
   Son PS, 2010, CARCINOGENESIS, V31, P1442, DOI 10.1093/carcin/bgq099
   Song FL, 2010, INT J MOL SCI, V11, P2362, DOI 10.3390/ijms11062362
   Stote KS, 2012, EUR J CLIN NUTR, V66, P1153, DOI 10.1038/ejcn.2012.101
   Su ZY, 2013, TOP CURR CHEM, V329, P133, DOI 10.1007/128_2012_340
   Trichopoulou A, 2009, BMJ-BRIT MED J, V338, DOI 10.1136/bmj.b2337
   Upadhyay S, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/504253
   Vaid M, 2010, INT J ONCOL, V36, P1053, DOI 10.3892/ijo_00000586
   Vidlar A, 2010, BRIT J NUTR, V104, P1181, DOI 10.1017/S0007114510002059
   Wang LK, 2014, INT J MOL SCI, V15, P16226, DOI 10.3390/ijms150916226
   Weseler AR, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0028460
   Wongcharoen W, 2012, AM J CARDIOL, V110, P40, DOI 10.1016/j.amjcard.2012.02.043
   Wood LG, 2012, AM J CLIN NUTR, V96, P534, DOI 10.3945/ajcn.111.032623
   Wu PT, 2015, J MED FOOD, V18, P941
   Wu RP, 2010, P NATL ACAD SCI USA, V107, P7479, DOI 10.1073/pnas.1002890107
   Xia ZY, 2005, J THORAC CARDIOV SUR, V130, P258, DOI 10.1016/j.jtcvs.2005.02.046
   Yadav VR, 2010, TOXINS, V2, P2428, DOI 10.3390/toxins2102428
   Zhang JY, 2013, J ETHNOPHARMACOL, V148, P563, DOI 10.1016/j.jep.2013.04.053
NR 120
TC 150
Z9 156
U1 4
U2 78
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2016
VL 22
IS 44
BP 6701
EP 6715
DI 10.2174/1381612823666161123094235
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EI9TK
UT WOS:000392851800009
PM 27881064
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Adekunle, OA
   Wang, YS
   Yunusa, I
   Fleming, ML
   Seoane-Vazquez, E
   Brown, LM
AF Adekunle, Olajide A.
   Wang, Yun S.
   Yunusa, Ismaeel
   Fleming, Marc L.
   Seoane-Vazquez, Enrique
   Brown, Lawrence M.
TI Predisposing, enabling, and need factors influencing health-related
   quality of life among people with metabolic syndrome
SO JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION
LA English
DT Article
ID NUTRITION EXAMINATION SURVEY; TYPE-2 DIABETIC-PATIENTS; NATIONAL-HEALTH;
   UNITED-STATES; BEHAVIORAL-MODEL; PREVALENCE; OBESITY; IMPACT; ADULTS;
   LEVEL
AB Background: Metabolic syndrome (MetS) continues to impact the health-related quality of life (HRQoL) of patients despite various available therapeutic interventions. There is a dearth of information on how patient-centered factors holistically predict HRQoL to provide more insights on addressing MetS. Objective: To predict the HRQoL of patients with MetS in the Southern states, using the predisposing, enabling, and need factors. Methods: The study adopted a cross-sectional approach in collecting 706 complete surveys on HRQoL assessment using the EQ-5D-5L survey and demographic characteristics based on the predisposing, enabling, and need factors of Andersen's Behavioral model. The study focused on people with MetS in the southern states of the United States. Multinomial logistic regression was conducted to investigate the relationship between the number of comorbidities and each HRQoL dimension. Ordinal regression was used to explore factors predicting HRQoL. Sensitivity analysis was conducted using bootstrapping analysis to evaluate the regression's robustness. Results: Over 70% were females and 30% had at least a bachelor's degree, while 47% were married. Most respondents (71.1%) had no problem with self-care. However, 20.0% had severe problems with pain, while the highest proportion (8.6%) was observed for extreme problems with anxiety or depression. A unit increase in comorbidities resulted in higher odds of having extreme problems with mobility (odds ratio [OR] = 1.95), usual activities (OR = 1.73), and pain (OR = 1.70). Only 40.8% of the respondents had good HRQoL, compared to 26.2% with poor HRQoL. Age, race, geographical area, marital status, household income, number of prescription drugs, comorbidities, and body mass index were predictors of HRQoL. Conclusion: An increase in comorbidities significantly increased the odds of having challenges with the HRQoL dimensions. Demographic, socioeconomic, and health-related factors significantly predicted HRQoL. Therefore, health care providers must consider these factors as a component of patient-centered care to address health disparities and promote optimal health outcomes among people with MetS. (c) 2024 American Pharmacists Association (R). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Brown, Lawrence M.] Chapman Univ, Sch Pharm, Dept Pharmaceut Econ & Policy, Undergraduate Pharm Programs & Partnerships, 9401 Jeronimo Rd, Irvine, CA 92618 USA.
   [Wang, Yun S.] Chapman Univ, Sch Pharm, Dept Biomed & Pharmaceut Sci, Irvine, CA USA.
   [Yunusa, Ismaeel] Univ South Carolina, Coll Pharm, Clin Pharm & Outcomes Sci CPOS, Columbia, SC USA.
   [Fleming, Marc L.] Chapman Univ, Sch Pharm, Dept Pharmaceut Econ & Policy, Irvine, CA USA.
   [Seoane-Vazquez, Enrique] Chapman Univ, Sch Pharm, Dept Pharmaceut Econ & Policy, Irvine, CA USA.
C3 Chapman University System; Chapman University; Chapman University
   System; Chapman University; University of South Carolina System;
   University of South Carolina Columbia; Chapman University System;
   Chapman University; Chapman University System; Chapman University
RP Brown, LM (corresponding author), Chapman Univ, Sch Pharm, Dept Pharmaceut Econ & Policy, Undergraduate Pharm Programs & Partnerships, 9401 Jeronimo Rd, Irvine, CA 92618 USA.
EM lbbrown@chapman.edu
RI YUN, WANG/AEQ-2146-2022; Yunusa, Ismaeel/X-2390-2019
OI Adekunle, Olajide/0000-0003-2627-300X; WANG, YUN/0000-0001-9438-5586;
   Yunusa, Ismaeel/0000-0002-9107-8561
FU Chapman University
FX The study was supported by Chapman University.
CR Adedokun B O, 2008, Ann Ib Postgrad Med, V6, P33
   Adriaanse MC, 2016, QUAL LIFE RES, V25, P175, DOI 10.1007/s11136-015-1061-0
   Agresti A., 2010, ANAL ORDINAL CATEGOR, DOI [DOI 10.1002/9780470594001, https://doi.org/10.1002/9780470594001]
   Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Alharbi M, 2022, HEALTH QUAL LIFE OUT, V20, DOI 10.1186/s12955-022-02040-7
   Amiri P, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0143167
   Amiri P, 2014, J DIABETES INVEST, V5, P687, DOI 10.1111/jdi.12222
   Amiri P, 2010, J WOMENS HEALTH, V19, P1201, DOI 10.1089/jwh.2009.1710
   ANDERSEN RM, 1995, J HEALTH SOC BEHAV, V36, P1, DOI 10.2307/2137284
   Andersen RM, 2008, MED CARE, V46, P647, DOI 10.1097/MLR.0b013e31817f4d48
   [Anonymous], 2022, Adult obesity prevalence maps
   Babitsch Birgit, 2012, Psychosoc Med, V9, pDoc11, DOI 10.3205/psm000089
   Bazargan M, 2018, BMC GERIATR, V18, DOI 10.1186/s12877-018-0926-9
   Bray GA, 2017, OBES REV, V18, P715, DOI 10.1111/obr.12551
   Cha J, 2020, OSONG PUBLIC HEALTH, V11, P194, DOI 10.24171/j.phrp.2020.11.4.08
   Cheville AL, 2022, ARCH PHYS MED REHAB, V103, pS24, DOI 10.1016/j.apmr.2021.10.031
   Corica F, 2008, INT J OBESITY, V32, P185, DOI 10.1038/sj.ijo.0803687
   DeBoer MD, 2019, PEDIATR OBES, V14, DOI 10.1111/ijpo.12483
   Devlin N PD., 2020, Analysis of EQ-5D Profiles. Methods for Analysing and Reporting EQ-5D Data, P27, DOI DOI 10.1007/978-3-030-47622-9_2
   EuroQOL, EQ-5D
   Faul F, 2007, BEHAV RES METHODS, V39, P175, DOI 10.3758/BF03193146
   Faul F, 2009, BEHAV RES METHODS, V41, P1149, DOI 10.3758/BRM.41.4.1149
   Gholami A, 2018, MED PRIN PRACT, V27, P166, DOI 10.1159/000487397
   Girma M, 2020, DIABET METAB SYND OB, V13, P4529, DOI 10.2147/DMSO.S279306
   Glueck J, 2019, J VALUE INQUIRY, V53, P349, DOI 10.1007/s10790-018-9661-x
   González-Bueno J, 2016, ATEN PRIM, V48, P121, DOI 10.1016/j.aprim.2015.02.012
   González-Chica DA, 2017, QUAL LIFE RES, V26, P1521, DOI 10.1007/s11136-017-1503-y
   Greene SJ, 2021, JAMA CARDIOL, V6, P522, DOI 10.1001/jamacardio.2021.0372
   Gurka MJ, 2018, NUTR DIABETES, V8, DOI 10.1038/s41387-018-0024-2
   Han JH, 2009, INT J CLIN PRACT, V63, P735, DOI 10.1111/j.1742-1241.2009.02021.x
   Hernández-Rubio A, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-06010-3
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Hohls JK, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph182212022
   IBM, 2021, SPSS statistics for Macintosh
   Jahangiry L, 2016, INT J PREVENTIVE MED, V7, DOI 10.4103/2008-7802.174893
   Jahromi AS, 2020, J FAM MED PRIM CARE, V9, P4662, DOI 10.4103/jfmpc.jfmpc_667_20
   Joseph SM, 2013, CIRC-HEART FAIL, V6, P1139, DOI 10.1161/CIRCHEARTFAILURE.113.000359
   Kalyuzhin VV, 2012, TERAPEVT ARKH, V84, P18
   Klompstra L, 2019, BMC GERIATR, V19, DOI 10.1186/s12877-019-1194-z
   Krzeminska S, 2020, DIABET METAB SYND OB, V13, P3773, DOI 10.2147/DMSO.S273339
   Lawson CA, 2023, ECLINICALMEDICINE, V64, DOI 10.1016/j.eclinm.2023.102217
   Le A, 2014, OBESITY, V22, P300, DOI 10.1002/oby.20451
   Lee YJ, 2012, ANN NUTR METAB, V61, P275, DOI 10.1159/000341494
   Liang XP, 2021, EUR HEART J, V42, P2420
   Lidfeldt J, 2003, DIABETES OBES METAB, V5, P106, DOI 10.1046/j.1463-1326.2003.00250.x
   Lin YH, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-99767-y
   Litwin M, 2021, PEDIATR NEPHROL, V36, P825, DOI 10.1007/s00467-020-04579-3
   Malhotra N, 2016, INDIAN J MED RES, V143, P434, DOI 10.4103/0971-5916.184284
   Mannan A, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0267713
   Mannan A, 2022, BMC PUBLIC HEALTH, V22, DOI 10.1186/s12889-022-12562-w
   Marcos-Delgado A, 2020, MED FAM-SEMERGEN, V46, P524, DOI 10.1016/j.semerg.2020.03.003
   Mircosoft Excel, 2022, ABOUT US
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   Ostrovskaya EV, 2019, RUSS OPEN MED J, V8, DOI 10.15275/rusomj.2019.0309
   Pi-Sunyer X, 2009, POSTGRAD MED, V121, P21, DOI 10.3810/pgm.2009.11.2074
   Puteh SEW, 2019, BMC PUBLIC HEALTH, V19, DOI 10.1186/s12889-019-6853-7
   Qualtrics XM, 2023, Survey management platform
   Raj CK, 2023, LARYNGOSCOPE, V133, P801, DOI 10.1002/lary.30295
   Rhubart Danielle C, 2021, Public Policy Aging Rep, V31, P24, DOI 10.1093/ppar/praa034
   Robinson JRM, 2021, CANCER EPIDEM BIOMAR, V30, P1366, DOI 10.1158/1055-9965.EPI-20-1823
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Sepúlveda E, 2015, DIABET METAB SYND OB, V8, P219, DOI 10.2147/DMSO.S80472
   Severino R, 2022, INT J EQUITY HEALTH, V21, DOI 10.1186/s12939-022-01770-w
   Sharmila J B., Indian Journal of Public Health Research and Development, DOI DOI 10.5958/0976-5506.2018.01843.0
   Shi TH, 2020, PREV CHRONIC DIS, V17, DOI 10.5888/pcd17.200020
   Rossi JLS, 2022, DIABETES-METAB RES, V38, DOI 10.1002/dmrr.3502
   Siqeca F, 2022, HEALTH QUAL LIFE OUT, V20, DOI 10.1186/s12955-022-02080-z
   Slagter SN, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0140599
   Stephenson J, 2021, BMC PUBLIC HEALTH, V21, DOI 10.1186/s12889-021-12009-8
   Tesfaye G, 2019, REPROD HEALTH, V16, DOI 10.1186/s12978-019-0829-z
   Travers JL, 2020, BMC GERIATR, V20, DOI 10.1186/s12877-019-1405-7
   Vijay-Kumar M, 2010, SCIENCE, V328, P228, DOI 10.1126/science.1179721
   Yin SM, 2016, POPUL HEALTH METR, V14, DOI 10.1186/s12963-016-0091-3
   Zhang JC, 2022, RISK MANAG HEALTHC P, V15, P1447, DOI 10.2147/RMHP.S373077
   Zhang SZ, 2019, INT J EQUITY HEALTH, V18, DOI 10.1186/s12939-019-0942-1
NR 75
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1544-3191
EI 1544-3450
J9 J AM PHARM ASSOC
JI J. Am. Pharm. Assoc.
PD JAN-FEB
PY 2025
VL 65
IS 1
AR 102255
DI 10.1016/j.japh.2024.102255
EA NOV 2024
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA L4S1W
UT WOS:001350623400001
PM 39384038
DA 2025-06-11
ER

PT J
AU Siqueira, JS
   Palacio, TLN
   Vieira, TA
   Nakandakare-Maia, ET
   Grandini, NA
   Ferron, AJT
   Francisqueti-Ferron, FV
   Correa, CR
AF Siqueira, Juliana Silva
   Palacio, Thiago Luiz Novaga
   Vieira, Taynara Aparecida
   Nakandakare-Maia, Erika Tiemi
   Grandini, Nubia Alves
   Ferron, Artur Junio Togneri
   Francisqueti-Ferron, Fabiane Valentini
   Correa, Camila Renata
TI An overview of the complex interaction between obesity and target organ
   dysfunction: focus on redox-inflammatory state
SO NUTRIRE
LA English
DT Review
DE Inflammation; Oxidative stress; Adipokines
ID NONALCOHOLIC FATTY LIVER; NECROSIS-FACTOR-ALPHA; BROWN ADIPOSE-TISSUE;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; HEART-FAILURE; METABOLIC SYNDROME;
   DISEASE; LEPTIN; MECHANISMS
AB The high consumption of simple carbohydrates and saturated fat is associated with a positive energy balance and fat accumulation. This scenario has been contributing to increase obesity rates in the world population in the last decades. Adipose tissue dysfunction has been associated with early stages of obesity-associated comorbidities due to several direct and indirect mechanisms, such as unregulated adipokine secretion, macrophage infiltration, inflammation, reduced antioxidant defense, and oxidative stress. These conditions can result in several metabolic disorders, among them, hypertension, dyslipidemia, insulin resistance besides with tissue and organ dysfunction. Thus, the better understanding of the processes involved in the pathophysiology of obesity and adipose tissue dysfunction can help in preventive and treatment studies in order to reduce obesity consequences.
C1 [Siqueira, Juliana Silva; Palacio, Thiago Luiz Novaga; Vieira, Taynara Aparecida; Nakandakare-Maia, Erika Tiemi; Grandini, Nubia Alves; Correa, Camila Renata] Sao Paulo State Univ UNESP, Botucatu Med Sch, Prof Montenegro Ave, BR-18618687 Botucatu, Brazil.
   [Ferron, Artur Junio Togneri] Integrated Coll Bauru FIB, Dept Phys Educ, BR-17056100 Bauru, Brazil.
   [Francisqueti-Ferron, Fabiane Valentini] Integrated Coll Bauru FIB, Dept Nutr, BR-17056100 Bauru, Brazil.
C3 Universidade Estadual Paulista
RP Siqueira, JS (corresponding author), Sao Paulo State Univ UNESP, Botucatu Med Sch, Prof Montenegro Ave, BR-18618687 Botucatu, Brazil.
EM juliana.siqueira@unesp.br
RI Correa, Camila/Q-2071-2019; Siqueira, Juliana/AAR-7994-2021; Alves
   Grandini, Nubia/HHZ-5975-2022; Francisqueti- Ferron,
   Fabiane/M-4919-2017; Novaga Palacio, Thiago Luiz/AGP-5802-2022;
   Aparecida Vieira, Taynara/JFK-7958-2023; Ferron, Artur Junio/M-5194-2017
OI Alves Grandini, Nubia/0000-0002-1696-4993; Correa, Camila
   Renata/0000-0001-8493-5329; Francisqueti- Ferron,
   Fabiane/0000-0003-2910-4308; Nakandakare Maia, Erika
   Tiemi/0000-0003-1253-001X; Novaga Palacio, Thiago
   Luiz/0000-0001-9568-7156; Aparecida Vieira, Taynara/0000-0002-5312-0060;
   Ferron, Artur Junio/0000-0001-7089-3033; Silva Siqueira,
   Juliana/0000-0003-3172-2199
FU Sao Paulo Research Foundation (FAPESP) [2021/07282-8]
FX This work is supported by the Sao Paulo Research Foundation (FAPESP),
   grant #2021/07282-8.
CR Al-Banna N, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/761789
   Aldini G, 2007, MED RES REV, V27, P817, DOI 10.1002/med.20073
   [Anonymous], 1931, Hippocrates Hippocrates Volume IV: Nature of Man. Regimen in Health. Humours. Aphorisms. Regimen 1-3. Dreams. Heracleitus: On the Universe, VIV
   Ansell BJ, 2003, CIRCULATION, V108, P2751, DOI 10.1161/01.CIR.0000103624.14436.4B
   Apostolopoulou M, 2018, DIABETES CARE, V41, P1235, DOI 10.2337/dc17-1318
   Arias-Loste MT, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17111878
   Asghar A, 2017, CELL IMMUNOL, V315, P18, DOI 10.1016/j.cellimm.2017.03.001
   Barbatelli G, 2010, AM J PHYSIOL-ENDOC M, V298, pE1244, DOI 10.1152/ajpendo.00600.2009
   Barcik W, 2020, IMMUNITY, V52, P241, DOI 10.1016/j.immuni.2020.01.007
   Barker G, 2021, CURR OPIN LIPIDOL, V32, P315, DOI 10.1097/MOL.0000000000000782
   Bhattacharya I, 2015, BIOCHEM BIOPH RES CO, V461, P287, DOI 10.1016/j.bbrc.2015.04.020
   Cachofeiro V, 2008, KIDNEY INT, V74, pS4, DOI 10.1038/ki.2008.516
   Choi HM, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21041219
   Cui HX, 2017, NAT REV ENDOCRINOL, V13, P338, DOI 10.1038/nrendo.2016.222
   Cypess AM, 2009, NEW ENGL J MED, V360, P1509, DOI 10.1056/NEJMoa0810780
   D'Agati V, 2010, NAT REV NEPHROL, V6, P352, DOI 10.1038/nrneph.2010.54
   D'Agati VD, 2016, NAT REV NEPHROL, V12, P453, DOI 10.1038/nrneph.2016.75
   Da Silva N. I., 2019, Revista EVS - Revista de Ciencias Ambientais e Saude, V46, DOI [10.18224/evs.v46i1.7179, DOI 10.18224/EVS.V46I1.7179]
   Rosa SCD, 2020, PHYSIOL REP, V8, DOI 10.14814/phy2.14607
   De AR, 2022, J HEPATOL, V76, P475, DOI 10.1016/j.jhep.2021.09.002
   Dietrich P, 2014, BEST PRACT RES CL GA, V28, P637, DOI 10.1016/j.bpg.2014.07.008
   DiNicolantonio JJ, 2018, PROG CARDIOVASC DIS, V61, P3, DOI 10.1016/j.pcad.2017.12.001
   Divella R, 2019, INT J BIOL SCI, V15, P610, DOI 10.7150/ijbs.29599
   Dixon AE, 2018, EXPERT REV RESP MED, V12, P755, DOI 10.1080/17476348.2018.1506331
   Drosatos Konstantinos, 2013, Curr Heart Fail Rep, V10, P109, DOI 10.1007/s11897-013-0133-0
   Dutka M, 2020, HEART FAIL REV, V25, P537, DOI 10.1007/s10741-019-09875-1
   Ebong IA, 2014, OBES RES CLIN PRACT, V8, pE540, DOI 10.1016/j.orcp.2013.12.005
   Ezzati M, 2017, LANCET, V390, P2627, DOI [10.1016/S0140-6736(17)32129-3, 10.1016/s0140-6736(17)32129-3]
   de Queiroz JCF, 2009, ARQ BRAS ENDOCRINOL, V53, P582, DOI 10.1590/S0004-27302009000500011
   Fonseca Raposo H., 2020, HU Rev, V46, P1, DOI [10.34019/1982-8047.2020.v46.31268, DOI 10.34019/1982-8047.2020.V46.31268]
   Foster MC, 2008, AM J KIDNEY DIS, V52, P39, DOI 10.1053/j.ajkd.2008.03.003
   Francisco V, 2019, BIOCHEM PHARMACOL, V165, P196, DOI 10.1016/j.bcp.2019.03.030
   Francisqueti F. V., 2015, Nutrire - Revista da Sociedade Brasileira de Alimentacao e Nutricao, V40, P81
   Francisqueti FV, 2017, REV ASSOC MED BRAS, V63, P85
   Francisqueti-Ferron FV, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20133208
   Gajjala PR, 2015, FRONT IMMUNOL, V6, DOI 10.3389/fimmu.2015.00340
   Gomes JMG, 2017, METABOLISM, V68, P133, DOI 10.1016/j.metabol.2016.12.009
   Ghoshal S, 2009, J LIPID RES, V50, P90, DOI 10.1194/jlr.M800156-JLR200
   Godoy-Matos AF, 2020, DIABETOL METAB SYNDR, V12, DOI 10.1186/s13098-020-00570-y
   González-Muniesa P, 2017, NAT REV DIS PRIMERS, V3, DOI 10.1038/nrdp.2017.34
   Grassi L, 2020, ANESTHESIOLOGY, V132, P1246, DOI 10.1097/ALN.0000000000003154
   Gutiérrez-Cuevas J, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10030629
   Hansel NN, 2009, EUR RESPIR J, V34, P103, DOI 10.1183/09031936.00120408
   Henry SL, 2012, INT J BIOCHEM CELL B, V44, P435, DOI 10.1016/j.biocel.2011.12.011
   Hibi M, 2016, INT J OBESITY, V40, P1655, DOI 10.1038/ijo.2016.124
   Hivert MF, 2008, J CLIN ENDOCR METAB, V93, P3165, DOI 10.1210/jc.2008-0425
   Hornung F, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22073456
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Hou KJ, 2022, SIGNAL TRANSDUCT TAR, V7, DOI 10.1038/s41392-022-00974-4
   Hsu PS, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20051078
   Hurrle S, 2017, BIOMED J, V40, P257, DOI 10.1016/j.bj.2017.06.007
   Jung UJ, 2014, INT J MOL SCI, V15, P6184, DOI 10.3390/ijms15046184
   Kaidar-Person O, 2008, OBES SURG, V18, P870, DOI 10.1007/s11695-007-9349-y
   Karmazyn M, 2008, CARDIOVASC RES, V79, P279, DOI 10.1093/cvr/cvn115
   Kim CW, 2017, CELL METAB, V26, P394, DOI 10.1016/j.cmet.2017.07.009
   Koliaki C, 2015, CELL METAB, V21, P739, DOI 10.1016/j.cmet.2015.04.004
   Kramer H, 2005, AM J KIDNEY DIS, V46, P587, DOI 10.1053/j.ajkd.2005.06.007
   La Cava A, 2017, CYTOKINE, V98, P51, DOI 10.1016/j.cyto.2016.10.011
   Lambertucci F, 2018, J NUTR BIOCHEM, V58, P17, DOI 10.1016/j.jnutbio.2018.04.013
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Lau K, 2017, NUTRIENTS, V9, DOI 10.3390/nu9080859
   Lee H, 2013, PEDIATR GASTROENTERO, V16, P143, DOI 10.5223/pghn.2013.16.3.143
   Longo M, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20092358
   Lv YQ, 2021, FRONT CELL DEV BIOL, V9, DOI 10.3389/fcell.2021.645400
   Mohan S, 2018, BIOMED PHARMACOTHER, V108, P1866, DOI 10.1016/j.biopha.2018.10.019
   Monteiro R, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/289645
   Mouzaki M, 2013, HEPATOLOGY, V58, P120, DOI 10.1002/hep.26319
   Murphy SP, 2020, J AM COLL CARDIOL, V75, P1324, DOI 10.1016/j.jacc.2020.01.014
   Myles IA, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-61
   Nita M, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/3164734
   Packer M, 2018, CIRCULATION, V137, P1614, DOI 10.1161/CIRCULATIONAHA.117.032474
   Palma G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23137349
   Peters U, 2018, CHEST, V153, P702, DOI 10.1016/j.chest.2017.07.010
   Petersen MC, 2017, TRENDS PHARMACOL SCI, V38, P649, DOI 10.1016/j.tips.2017.04.004
   Popkin BM, 2012, NUTR REV, V70, P3, DOI 10.1111/j.1753-4887.2011.00456.x
   Raimundo M, 2011, CARDIOL RES PRACT, V2011, DOI 10.4061/2011/747861
   Ramos-Ramírez P, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21238990
   Rao A, 2015, ADV CHRONIC KIDNEY D, V22, P211, DOI 10.1053/j.ackd.2014.12.004
   Reyes-Farias M, 2021, BIOCHEM PHARMACOL, V192, DOI 10.1016/j.bcp.2021.114723
   Richard AJ, 2000, Adipose Tissue: Physiology to Metabolic Dysfunction
   Rosen ED, 2000, GENE DEV, V14, P1293
   Sacks HS, 2011, CLIN EXP PHARMACOL P, V38, P879, DOI 10.1111/j.1440-1681.2011.05601.x
   Sanchez-Rodriguez E, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030605
   Scheithauer TPM, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.571731
   Schenk S, 2008, J CLIN INVEST, V118, P2992, DOI 10.1172/JCI34260
   Schofield JH, 2021, ANTIOXID REDOX SIGN, V34, P517, DOI 10.1089/ars.2020.8058
   Sethi JK, 2021, NAT METAB, V3, P1302, DOI 10.1038/s42255-021-00470-z
   Shirakawa K, 2016, J CLIN INVEST, V126, P4626, DOI 10.1172/JCI88606
   Sies H., 1985, OXIDATIVE STRESS, P1, DOI DOI 10.1016/B978-0-12-642760-8.50005-3
   Siqueira JS, 2021, J BRAS NEFROL, V43, P156, DOI [10.1590/2175-8239-JBN-2020-0169, 10.1590/2175-8239-jbn-2020-0169]
   Song MJ, 2006, BIOCHEM BIOPH RES CO, V346, P739, DOI 10.1016/j.bbrc.2006.05.170
   Sowers JR, 2009, ANN INTERN MED, V150, P776, DOI 10.7326/0003-4819-150-11-200906020-00005
   Stasi A, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.925619
   Stefan N, 2019, LANCET DIABETES ENDO, V7, P313, DOI 10.1016/S2213-8587(18)30154-2
   Suganami T, 2010, J LEUKOCYTE BIOL, V88, P33, DOI 10.1189/jlb.0210072
   Symons JD, 2013, REV ENDOCR METAB DIS, V14, P59, DOI 10.1007/s11154-012-9235-3
   Taouis M, 2021, MOL CELL ENDOCRINOL, V533, DOI 10.1016/j.mce.2021.111341
   Thaiss CA, 2016, NATURE, V535, P65, DOI 10.1038/nature18847
   Trinh T, 2021, STEM CELL REV REP, V17, P511, DOI 10.1007/s12015-021-10132-y
   Tsutsui H, 2011, AM J PHYSIOL-HEART C, V301, pH2181, DOI 10.1152/ajpheart.00554.2011
   Turer AT, 2012, CIRC RES, V111, P1565, DOI [10.1161/CIRCRESAHA.111.262493, 10.1161/circresaha.111.262493]
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Uysal KT, 1998, ENDOCRINOLOGY, V139, P4832, DOI 10.1210/en.139.12.4832
   Vasan RS, 2003, HEART, V89, P1127, DOI 10.1136/heart.89.10.1127
   Vistoli G, 2013, FREE RADICAL RES, V47, P3, DOI 10.3109/10715762.2013.815348
   Wallström P, 2001, AM J CLIN NUTR, V73, P777
   Watt MJ, 2012, DIABETOLOGIA, V55, P2741, DOI 10.1007/s00125-012-2649-3
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   WHO, 2021, Obesity and overweight
   Wu J, 2013, GENE DEV, V27, P234, DOI 10.1101/gad.211649.112
   Zatterale F, 2020, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.01607
   Zhang X, 2017, TRANSL RES, V183, P14, DOI 10.1016/j.trsl.2016.12.004
   ZHANG YY, 1994, NATURE, V372, P425, DOI 10.1038/372425a0
NR 113
TC 4
Z9 4
U1 2
U2 3
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2316-7874
J9 NUTRIRE
JI Nutrire
PD APR 10
PY 2023
VL 48
IS 1
AR 21
DI 10.1186/s41110-023-00206-x
PG 13
WC Food Science & Technology; Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Food Science & Technology; Nutrition & Dietetics
GA XA2E8
UT WOS:001258886600001
DA 2025-06-11
ER

PT J
AU Shi, SB
   Li, L
   Song, LN
   Wang, XR
AF Shi, Shaobo
   Li, Lu
   Song, Lina
   Wang, Xinrui
TI Effect of lamotrigine on cognitive function and serum inflammatory
   factors in patients with depression of recurrent bipolar disorder
SO PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Bipolar disorder; lamotrigine; cognitive function; inflammatory factors
ID METABOLIC SYNDROME; RISK
AB In the present study, an effort was made to investigate the effect of lamotrigine on cognitive function and serum inflammatory factors in patients with depression of recurrent bipolar disorder and to explore its possible mechanism.140 patients with depression of recurrent bipolar disorder, admitted from June 2015 to April 2017, were selected as the research subjects, followed by random division into the research group and the control group with 70 cases (n=70) in each group. The control group was treated with sodium valproate and the research group was treated with lamotrigine. After 2 months of treatment, comparison was made between the two groups for the emotional state, cognitive function and serum inflammatory factors. Results showed that the Hamilton Depression Scale (HAMD) score and Bech-Rafaelsen Mania Rating Scale BRMS score in the research group were significantly lower than in the control group (P<0.05). The time of Trail Making Test-A(TMT-A) and Trail Making Test-B(TMT-B) in the research group was significantly shorter than that of the control group, with a statistically significant difference (P<0.05). The serum levels of MIF, IL-1 beta and IL-6 in the research group were significantly lower than those in the control group and the difference was statistically significant (P<0.05). Research concluded that lamotrigine may help alleviate the clinical symptoms and improve cognitive function in patients with depression of recurrent bipolar disorder.
C1 [Shi, Shaobo; Li, Lu; Song, Lina; Wang, Xinrui] Mental Hlth Ctr Qingdao, Dept Psychiat, Qingdao, Peoples R China.
RP Shi, SB (corresponding author), Mental Hlth Ctr Qingdao, Dept Psychiat, Qingdao, Peoples R China.
EM sci477@aliyun.com
CR Altamura AC, 2008, J AFFECT DISORDERS, V110, P135, DOI 10.1016/j.jad.2008.01.017
   Benedetti F, 2016, J AFFECT DISORDERS, V202, P1, DOI 10.1016/j.jad.2016.05.047
   Bick J, 2015, DEV PSYCHOBIOL, V57, P131, DOI 10.1002/dev.21265
   Green T, 2013, HAREFUAH, V144, P810
   Hatch JK, 2017, J CLIN PSYCHIAT, V78, pE286, DOI 10.4088/JCP.16m10762
   Liège S, 2000, NEUROIMMUNOMODULAT, V7, P189, DOI 10.1159/000026438
   Lin M, 2001, Hua Xi Yi Ke Da Xue Xue Bao, V32, P576
   Malhotra N, 2013, J AFFECT DISORDERS, V150, P653, DOI 10.1016/j.jad.2013.03.010
   McVearry KM, 2009, EPILEPSY BEHAV, V16, P609, DOI 10.1016/j.yebeh.2009.09.024
   Mitchell PB, 2013, CNS SPECTRUMS, V18, P214, DOI 10.1017/S1092852913000291
   Panou T, 2012, BEHAV NEUROL, V25, P311, DOI 10.1155/2012/105471
   Price AL, 2012, AM FAM PHYSICIAN, V85, P483
   Robinson LJ, 2015, J INT NEUROPSYCH SOC, V21, P709, DOI 10.1017/S1355617715000909
   Viguera AC, 2007, AM J PSYCHIAT, V164, P1817, DOI 10.1176/appi.ajp.2007.06101639
   Vuksan-Cusa B, 2010, PSYCHIAT DANUB, V22, P275
NR 15
TC 8
Z9 8
U1 1
U2 4
PU UNIV KARACHI
PI KARACHI
PA UNIV CAMPUS, FAC PHARMACY, KARACHI, 75270, PAKISTAN
SN 1011-601X
J9 PAK J PHARM SCI
JI Pak. J. Pharm. Sci.
PD NOV
PY 2018
VL 31
IS 6
SI SI
BP 2775
EP 2778
PG 4
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HI5KY
UT WOS:000456492100003
PM 30630782
DA 2025-06-11
ER

PT J
AU Reljic, D
   Koller, A
   Herrmann, HJ
   Ekici, AB
   Neurath, MF
   Zopf, Y
AF Reljic, Dejan
   Koller, Adriana
   Herrmann, Hans J.
   Ekici, Arif B.
   Neurath, Markus F.
   Zopf, Yurdagul
TI Differential Effects of Very-Low-Volume Exercise Modalities on Telomere
   Length, Inflammation, and Cardiometabolic Health in Obese Metabolic
   Syndrome Patients: A Subanalysis from Two Randomized Controlled Trials
SO ANTIOXIDANTS
LA English
DT Article
DE telomeres; cellular age; high-intensity interval training; resistance
   training; electromyostimulation; metabolic diseases; oxidative stress;
   inflammatory markers; anti-aging
ID C-REACTIVE PROTEIN; PHYSICAL-ACTIVITY; OXIDATIVE STRESS; PERCEIVED
   EXERTION; GENDER-DIFFERENCES; RISK-FACTORS; WEIGHT-LOSS; INTENSITY;
   ASSOCIATION; ADULTS
AB Oxidative stress (OS) and inflammation are features of metabolic syndrome (MetS) that can contribute to the shortening of telomere length (TL), a marker of cellular ageing. Research indicates that exercise can positively influence MetS-associated conditions and TL. However, the effects of low-volume exercise types on TL are still unknown. We investigated the impact of very-low-volume high-intensity interval training (LV-HIIT), one-set resistance training (1-RT), and whole-body electromyostimulation (WB-EMS) on TL, inflammation, and cardiometabolic indices in 167 MetS patients. Data were derived from two randomized controlled trials where patients were allocated to an exercise group (2 sessions/week, for 12 weeks) or a control group. All groups received standard-care nutritional weight loss counselling. TL was determined as the T/S ratio (telomere to single-copy gene amount). All groups significantly reduced body weight (p < 0.05), but the T/S-ratio (p < 0.001) only increased with LV-HIIT. OS-related inflammatory markers (C-reactive protein, interleukin-6, and lipopolysaccharide-binding protein) only decreased (p < 0.05) following LV-HIIT. The MetS severity z-score improved with LV-HIIT (p < 0.001) and 1-RT (p = 0.014) but not with WB-EMS. In conclusion, very-low-volume exercise modalities have differential effects on telomeres, inflammation, and cardiometabolic health. Only LV-HIIT but not strength-based low-volume exercise increased TL in MetS patients, presumably due to superior effects on OS-related inflammatory markers.
C1 [Reljic, Dejan; Herrmann, Hans J.; Neurath, Markus F.; Zopf, Yurdagul] Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, Dept Med 1, D-91054 Erlangen, Germany.
   [Reljic, Dejan; Herrmann, Hans J.; Zopf, Yurdagul] Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, Hector Ctr Nutr Exercise & Sports, Dept Med 1, D-91054 Erlangen, Germany.
   [Reljic, Dejan; Herrmann, Hans J.; Neurath, Markus F.; Zopf, Yurdagul] Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, German Ctr Immunotherapy DZI, D-91054 Erlangen, Germany.
   [Koller, Adriana] Med Univ Innsbruck, Inst Genet Epidemiol, A-6020 Innsbruck, Austria.
   [Ekici, Arif B.] Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, Inst Human Genet, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg;
   University of Erlangen Nuremberg; Medical University of Innsbruck;
   University of Erlangen Nuremberg
RP Reljic, D (corresponding author), Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, Dept Med 1, D-91054 Erlangen, Germany.; Reljic, D (corresponding author), Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, Hector Ctr Nutr Exercise & Sports, Dept Med 1, D-91054 Erlangen, Germany.; Reljic, D (corresponding author), Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, German Ctr Immunotherapy DZI, D-91054 Erlangen, Germany.
EM dejan.reljic@uk-erlangen.de; adriana.koller@i-med.ac.at;
   hans.herrmann@uk-erlangen.de; arif.ekici@uk-erlangen.de;
   yurdaguel.zopf@uk-erlangen.de
RI Reljic, Dejan/CAG-1377-2022; Ekici, Arif/C-3971-2013
OI Reljic, Dejan/0000-0001-8049-1775; Zopf, Yurdagul/0000-0002-3432-7488;
   Koller, Adriana/0000-0002-5595-4376; Herrmann, Hans
   Joachim/0000-0002-3021-8022; Ekici, Arif/0000-0001-6099-7066
FU The authors greatly appreciate the valuable support of the following
   persons who contributed to the implementation of this study: Walburga
   Dieterich for setting up and supervising the measurements of the
   inflammatory biomarkers; Alisia Gerl, Melanie Klaus
FX The authors greatly appreciate the valuable support of the following
   persons who contributed to the implementation of this study: Walburga
   Dieterich for setting up and supervising the measurements of the
   inflammatory biomarkers; Alisia Gerl, Melanie Klau ss ner, Maike
   Tobschall, and Kerstin Weidlich for supervising and instructing the
   exercise sessions; and Kathinka Faustka and Julia Kratzer for their
   assistance in data collection. We especially thank all patients for
   their willingness to participate in this investigation.
CR Aguiar SS, 2021, EXP GERONTOL, V146, DOI 10.1016/j.exger.2020.111212
   Al-Nimr Rima Itani, 2019, Journal of Nutrition in Gerontology and Geriatrics, V38, P50, DOI 10.1080/21551197.2018.1544533
   Alvarez C, 2016, INT J SPORTS MED, V37, P723, DOI 10.1055/s-0042-104935
   Aristizabal JC, 2021, ANN NUTR METAB, V77, P279, DOI 10.1159/000518909
   Auriemma RS, 2021, J ENDOCRINOL INVEST, V44, P2845, DOI 10.1007/s40618-021-01563-y
   Balan E, 2018, NUTRIENTS, V10, DOI 10.3390/nu10121942
   BEAVER WL, 1986, J APPL PHYSIOL, V60, P2020, DOI 10.1152/jappl.1986.60.6.2020
   Bogdanis GC, 2013, FOOD CHEM TOXICOL, V61, P171, DOI 10.1016/j.fct.2013.05.046
   Borg E, 2006, SCAND J MED SCI SPOR, V16, P57, DOI 10.1111/j.1600-0838.2005.00448.x
   BORG G, 1982, INT J SPORTS MED, V3, P153, DOI 10.1055/s-2008-1026080
   Bosy-Westphal A, 2017, EUR J CLIN NUTR, V71, P1061, DOI 10.1038/ejcn.2017.27
   Carels RA, 2008, ANN BEHAV MED, V35, pS43, DOI 10.1016/j.eatbeh.2007.12.003
   Cavallini M F., 2020, Journal of Physical Activity Research, V5, P100, DOI DOI 10.12691/JPAR-5-2-6
   Cheng FF, 2021, LANCET DIABETES ENDO, V9, P117, DOI 10.1016/S2213-8587(20)30365-X
   Cherkas LF, 2008, ARCH INTERN MED, V168, P154, DOI 10.1001/archinternmed.2007.39
   Cohen J., 1988, STAT POWER ANAL BEHA, DOI [10.4324/9780203771587, DOI 10.4324/9780203771587]
   Colon M, 2019, J AGING PHYS ACTIV, V27, P510, DOI 10.1123/japa.2018-0248
   Crane MM, 2017, AM J MENS HEALTH, V11, P369, DOI 10.1177/1557988316681221
   D'Mello MJJ, 2015, CIRC-CARDIOVASC GENE, V8, P82, DOI 10.1161/CIRCGENETICS.113.000485
   Daniels NF, 2022, CURR DEV NUTR, V6, DOI 10.1093/cdn/nzac011
   Deng YJ, 2022, FRONT CARDIOVASC MED, V9, DOI 10.3389/fcvm.2022.1012615
   Didion SP, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18122563
   Du MM, 2012, AM J EPIDEMIOL, V175, P414, DOI 10.1093/aje/kwr330
   Earnest CP, 2013, MAYO CLIN PROC, V88, P259, DOI 10.1016/j.mayocp.2012.11.006
   Eigendorf J, 2019, EUR J PREV CARDIOL, V26, P1903, DOI 10.1177/2047487319849505
   Escribano BM, 2017, NEUROTHERAPEUTICS, V14, P199, DOI 10.1007/s13311-016-0480-0
   Esposito K, 2012, DIABETES CARE, V35, P2402, DOI 10.2337/dc12-0336
   de la Puente MF, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10101596
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Friedenreich CM, 2018, CANCER EPIDEMIOL, V56, P67, DOI 10.1016/j.canep.2018.07.012
   Galiè S, 2020, ADV NUTR, V11, P576, DOI 10.1093/advances/nmz107
   Garber CE, 2011, MED SCI SPORT EXER, V43, P1334, DOI 10.1249/MSS.0b013e318213fefb
   Gasteyger C, 2009, DIABETES OBES METAB, V11, P596, DOI 10.1111/j.1463-1326.2008.01025.x
   Gavia-García G, 2021, BIOLOGY-BASEL, V10, DOI 10.3390/biology10040253
   Gibala MJ, 2020, J PHYSIOL-LONDON, V598, P61, DOI 10.1113/JP276849
   Gibala MJ, 2014, SPORTS MED, V44, pS127, DOI 10.1007/s40279-014-0259-6
   Gill RS, 2012, CAN J SURG, V55, P239, DOI 10.1503/cjs.035710
   Gillen JB, 2014, APPL PHYSIOL NUTR ME, V39, P409, DOI 10.1139/apnm-2013-0187
   Gormley SE, 2008, MED SCI SPORT EXER, V40, P1336, DOI 10.1249/MSS.0b013e31816c4839
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Guthold R, 2018, LANCET GLOB HEALTH, V6, pE1077, DOI [10.1016/S2214-109X(18)30357-7, 10.1016/s2214-109x(18)30357-7]
   Hagstrom A.D., 2018, J. Funct. Morphol. Kinesiol, V3, DOI [10.3390/jfmk3010009, DOI 10.3390/JFMK3010009]
   Hausmann M, 2007, AKTUEL ERNAHRUNGSMED, V32, P185, DOI 10.1055/s-2007-970920
   Herazo-Beltrán Y, 2017, BRAZ J PHYS THER, V21, P44, DOI 10.1016/j.bjpt.2016.04.003
   Higgs C, 2016, J PRIM HEALTH CARE, V8, P130, DOI 10.1071/HC15038
   Hoare E, 2017, SPORTS, V5, DOI 10.3390/sports5030047
   HOWLEY ET, 1995, MED SCI SPORT EXER, V27, P1292
   Hui WS, 2010, EUR J EPIDEMIOL, V25, P375, DOI 10.1007/s10654-010-9459-z
   Iversen VM, 2021, SPORTS MED, V51, P2079, DOI 10.1007/s40279-021-01490-1
   Johnson JL, 2007, AM J CARDIOL, V100, P1759, DOI 10.1016/j.amjcard.2007.07.027
   Kavanagh T, 2002, CIRCULATION, V106, P666, DOI 10.1161/01.CIR.0000024413.15949.ED
   Kelishadi R, 2007, CLIN CHEM, V53, P456, DOI 10.1373/clinchem.2006.073668
   Kemmler W, 2023, FRONT PHYSIOL, V14, DOI 10.3389/fphys.2023.1174103
   Kemmler W, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.00523
   Kemmler W, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00573
   Knox ECL, 2014, EUR J PUBLIC HEALTH, V24, P195, DOI 10.1093/eurpub/ckt060
   Koller A, 2022, INVEST OPHTH VIS SCI, V63, DOI 10.1167/iovs.63.5.30
   Kordinas V, 2016, GENES-BASEL, V7, DOI 10.3390/genes7090060
   Kraemer WJ, 2002, MED SCI SPORT EXER, V34, P364, DOI 10.1097/00005768-200202000-00027
   Krzysztofik M, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16244897
   Law MR, 2009, BMJ-BRIT MED J, V338, DOI 10.1136/bmj.b1665
   Lejawa M, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10010093
   Little JP, 2011, J APPL PHYSIOL, V111, P1554, DOI 10.1152/japplphysiol.00921.2011
   Liu S, 2023, EXP GERONTOL, V174, DOI 10.1016/j.exger.2023.112132
   Lopez P, 2021, MED SCI SPORT EXER, V53, P1206, DOI 10.1249/MSS.0000000000002585
   Loprinzi PA, 2016, PREV MED, V85, P17, DOI 10.1016/j.ypmed.2016.01.002
   Lu YN, 2021, BIOLOGY-BASEL, V10, DOI 10.3390/biology10121272
   Madsen SM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0133286
   Marott SCW, 2016, J CLIN ENDOCR METAB, V101, P3212, DOI 10.1210/jc.2015-3777
   Marques A, 2020, J SPORT SCI, V38, P1690, DOI 10.1080/02640414.2020.1754739
   Martin Crescent B, 2018, NCHS Data Brief, P1
   Mason C, 2013, OBESITY, V21, pE549, DOI 10.1002/oby.20509
   Mattocks T., 2016, J. Trainol, V5, P6
   Milanovic Z, 2015, SPORTS MED, V45, P1469, DOI 10.1007/s40279-015-0365-0
   Monserrat-Mesquida M, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9030236
   Mosallanezhad Z., 2019, J. Urmia Univ. Med. Sci, V29, P913
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Nannini DR, 2019, CLIN EPIGENETICS, V11, DOI 10.1186/s13148-019-0767-1
   Nettleton JA, 2008, AM J CLIN NUTR, V88, P1405, DOI 10.3945/ajcn.2008.26429
   Nomikos NN, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01798
   Noorimofrad S., 2018, J Basic Res Med Sci, V5, P1
   Noubiap JJ, 2022, DIABETES RES CLIN PR, V188, DOI 10.1016/j.diabres.2022.109924
   Ogawa EF, 2017, MED SCI SPORT EXER, V49, P1371, DOI 10.1249/MSS.0000000000001253
   Okamura M, 2023, HEART FAIL REV, V28, P1113, DOI 10.1007/s10741-023-10316-3
   Pano-Rodriguez A, 2019, BMC COMPLEM ALTERN M, V19, DOI 10.1186/s12906-019-2485-9
   Park S, 2013, CLIN ENDOCRINOL, V79, P65, DOI 10.1111/j.1365-2265.2012.04512.x
   Pauleck S, 2023, CANCERS, V15, DOI 10.3390/cancers15041159
   Aro CEP, 2015, MEDWAVE, V15, DOI 10.5867/medwave.2015.07.6212
   Powers SK, 2020, J SPORT HEALTH SCI, V9, P415, DOI 10.1016/j.jshs.2020.04.001
   Puterman E, 2018, PSYCHONEUROENDOCRINO, V98, P245, DOI 10.1016/j.psyneuen.2018.08.002
   Qiu Y, 2023, J SPORT HEALTH SCI, V12, P8, DOI 10.1016/j.jshs.2022.10.003
   Reljic D, 2021, J PHYSIOL PHARMACOL, V72, P927, DOI 10.26402/jpp.2021.6.10
   Reljic D, 2020, J PHYSIOL PHARMACOL, V71, P89, DOI 10.26402/jpp.2020.1.08
   Reljic D, 2023, HEALTHCARE-BASEL, V11, DOI 10.3390/healthcare11050711
   Reljic D, 2022, NUTRIENTS, V14, DOI 10.3390/nu14101996
   Reljic D, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051640
   Reljic D, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-82372-4
   Reljic D, 2020, J TRANSL MED, V18, DOI 10.1186/s12967-020-02592-6
   Reljic D, 2019, SCAND J MED SCI SPOR, V29, P1288, DOI 10.1111/sms.13452
   Reljic D, 2018, EUR J APPL PHYSIOL, V118, P1153, DOI 10.1007/s00421-018-3845-8
   Ribeiro VB, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph182111274
   Rode L, 2015, JNCI-J NATL CANCER I, V107, DOI 10.1093/jnci/djv074
   Ruijter JM, 2009, NUCLEIC ACIDS RES, V37, DOI 10.1093/nar/gkp045
   Sabag A, 2020, DIABETES CARE, V43, P2371, DOI 10.2337/dc19-2523
   Saenroth D, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0142131
   Saghaei M., 2011, J BIOMED SCI ENG, V4, P734, DOI 10.4236/jbise.2011.411090
   Sagris M, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms232416010
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Schellnegger M, 2022, SPORTS MED-OPEN, V8, DOI 10.1186/s40798-022-00503-1
   Schneider CV, 2022, JAMA INTERN MED, V182, P291, DOI 10.1001/jamainternmed.2021.7804
   Sellami M, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10071035
   Shadyab AH, 2017, J GERONTOL A-BIOL, V72, P1532, DOI 10.1093/gerona/glx037
   Shailendra P, 2022, AM J PREV MED, V63, P277, DOI 10.1016/j.amepre.2022.03.020
   Shin YA, 2008, MECH AGEING DEV, V129, P254, DOI 10.1016/j.mad.2008.01.001
   Shin YA, 2019, J OBES METAB SYNDR, V28, P92, DOI 10.7570/jomes.2019.28.2.92
   Sillanpää E, 2016, AGE, V38, DOI 10.1007/s11357-016-9898-x
   Stenbäck V, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00444
   Strasser B, 2011, J OBES, V2011, DOI 10.1155/2011/482564
   Strauss J.A., 2020, Cochrane Database Syst Rev, V2020, pCD013617, DOI [10.1002/14651858, DOI 10.1002/14651858]
   Taylor JL, 2019, PROG CARDIOVASC DIS, V62, P140, DOI 10.1016/j.pcad.2019.01.004
   Thompson WR., 2010, ACSM's Guidelines for Exercise Testing and Prescription, V8th
   Tosevska A, 2016, SCI REP-UK, V6, DOI 10.1038/srep38084
   Tucker LA, 2017, PREV MED, V100, P145, DOI 10.1016/j.ypmed.2017.04.027
   Tudor-Locke C, 2010, INT J BEHAV NUTR PHY, V7, DOI 10.1186/1479-5868-7-60
   Vaiserman A, 2021, FRONT GENET, V11, DOI 10.3389/fgene.2020.630186
   Werner C, 2009, CIRCULATION, V120, P2438, DOI 10.1161/CIRCULATIONAHA.109.861005
   Werner CM, 2019, EUR HEART J, V40, P34, DOI 10.1093/eurheartj/ehy585
   Westcott WL, 2012, CURR SPORT MED REP, V11, P209, DOI 10.1249/JSR.0b013e31825dabb8
   Whelton PK, 2018, CIRCULATION, V138, pE426, DOI 10.1161/CIR.0000000000000597
   Willeit P, 2010, JAMA-J AM MED ASSOC, V304, P69, DOI 10.1001/jama.2010.897
   Winding KM, 2018, DIABETES OBES METAB, V20, P1131, DOI 10.1111/dom.13198
   Wirth A, 1998, OBES RES, V6, P393, DOI 10.1002/j.1550-8528.1998.tb00370.x
   Xu WW, 2022, FRONT PUBLIC HEALTH, V10, DOI 10.3389/fpubh.2022.885013
   Yin H, 2023, CURR ATHEROSCLER REP, V25, P95, DOI 10.1007/s11883-023-01082-6
   Zhang CL, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0133174
   ,, 2010, Global recommendations on physical activity for health
NR 136
TC 3
Z9 3
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD OCT
PY 2023
VL 12
IS 10
AR 1847
DI 10.3390/antiox12101847
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA X4PY3
UT WOS:001098299300001
PM 37891926
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Schinzari, F
   Tesauro, M
   Rovella, V
   Galli, A
   Mores, N
   Porzio, O
   Lauro, D
   Cardillo, C
AF Schinzari, Francesca
   Tesauro, Manfredi
   Rovella, Valentina
   Galli, Angelica
   Mores, Nadia
   Porzio, Ottavia
   lauro, DaviDe
   Cardillo, Carmine
TI Generalized impairment of vasodilator reactivity during hyperinsulinemia
   in patients with obesity-related metabolic syndrome
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE insulin; oxidative stress; vasodilation
ID TUMOR-NECROSIS-FACTOR; SMOOTH-MUSCLE-CELLS; INSULIN-RESISTANCE;
   PERIVASCULAR FAT; NITRIC-OXIDE; FACTOR-ALPHA; DYSFUNCTION; EXPRESSION;
   HUMANS; HYPERTENSION
AB Defective insulin-dependent vasodilation might contribute importantly to metabolic and vascular abnormalities of the metabolic syndrome (MetS). However, despite extensive investigation, the precise mechanisms involved in insulin's vasoactive effects have not been fully elucidated. Therefore, this study sought to better characterize insulin's physiological actions on vascular reactivity and their potential derangement in the MetS. Forearm blood flow responses to graded doses of acetylcholine, sodium nitroprusside, and verapamil were assessed by strain-gauge plethysmography in patients with obesity-related MetS (n = 20) and in matched controls (n = 18) before and after intra-arterial infusion of insulin (0.2 mU.kg(-1).min(-1)). Possible involvement of increased oxidative stress in the impaired insulin-stimulated vasodilator responsiveness of patients with MetS (n = 12) was also investigated using vitamin C (25 mg/min). In control subjects, significant potentiation of the vasodilator responses to acetylcholine, nitroprusside, and verapamil was observed after insulin infusion (all P < 0.05). However, no significant change in vasodilator reactivity to either of these drugs was observed following hyperinsulinemia in patients with MetS (all P > 0.05). Interestingly, administration of vitamin C to patients with MetS during hyperinsulinemia significantly enhanced the vasodilator responsiveness to acetylcholine, nitroprusside, and verapamil (all P < 0.05 vs. hyperinsulinemia alone). In conclusion, insulin exerts a generalized facilitatory action on vasodilator reactivity, and this effect is impaired in patients with MetS likely because of increased oxidative stress. Given the importance of vasodilator reactivity in affecting glucose disposal and vascular homeostasis, this defect may then contribute to the development of metabolic and vascular complications in insulin-resistant states.
C1 [Schinzari, Francesca; Cardillo, Carmine] Univ Cattolica Sacro Cuore, Sch Med, Dept Internal Med, Rome, Italy.
   [Mores, Nadia] Univ Cattolica Sacro Cuore, Sch Med, Dept Pharmacol, Rome, Italy.
   [Tesauro, Manfredi; Rovella, Valentina; Galli, Angelica; lauro, DaviDe] Univ Roma Tor Vergata, Dept Internal Med, Rome, Italy.
   [Porzio, Ottavia] Univ Roma Tor Vergata, Dept Biochem, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   University of Rome Tor Vergata; University of Rome Tor Vergata
RP Cardillo, C (corresponding author), Univ Cattolica Sacro Cuore, Ist Patol Speciale Med & Semeiot Med, Largo Gemelli 8, I-00168 Rome, Italy.
EM carmine.cardillo@rm.unicatt.it
RI schinzari, francesca/AAB-9982-2019; Rovella, Valentina/AAB-9727-2019
OI MORES, Nadia/0000-0002-4197-0914; PORZIO, OTTAVIA/0000-0001-5931-8679;
   Lauro, Davide/0000-0002-8597-4415; Rovella,
   Valentina/0000-0002-3311-486X; Cardillo, Carmine/0000-0001-5182-3005
FU Universita Cattolica del Sacro Cuore; Italian Ministero dell'Istruzione
FX This work was partially supported by Fondi d'Ateneo grants from the
   Universita Cattolica del Sacro Cuore and by a PRIN 2007 grant from the
   Italian Ministero dell'Istruzione to C. Cardillo.
CR BARON AD, 1995, J CLIN INVEST, V96, P786, DOI 10.1172/JCI118124
   Clark MG, 2008, AM J PHYSIOL-ENDOC M, V295, pE732, DOI 10.1152/ajpendo.90477.2008
   Coggins M, 2001, DIABETES, V50, P2682, DOI 10.2337/diabetes.50.12.2682
   Dimitropoulou C, 2002, AM J PHYSIOL-HEART C, V282, pH908, DOI 10.1152/ajpheart.00382.2001
   Frank GD, 2005, ANTIOXID REDOX SIGN, V7, P1053, DOI 10.1089/ars.2005.7.1053
   Gardner CA, 2003, EXP BIOL MED, V228, P836, DOI 10.1177/15353702-0322807-09
   Greenstein AS, 2009, CIRCULATION, V119, P1661, DOI 10.1161/CIRCULATIONAHA.108.821181
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   HOTAMISLIGIL GS, 1995, J CLIN INVEST, V95, P2409, DOI 10.1172/JCI117936
   Jackson TS, 1998, CIRC RES, V83, P916
   Jonk AM, 2007, PHYSIOLOGY, V22, P252, DOI 10.1152/physiol.00012.2007
   Kahn BB, 2000, J CLIN INVEST, V106, P473, DOI 10.1172/JCI10842
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   Kern PA, 2001, AM J PHYSIOL-ENDOC M, V280, pE745
   Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2448
   Rajsheker S, 2009, CURR OPIN PHARMACOL, V10, P1
   Rask-Madsen C, 2003, CIRCULATION, V108, P1815, DOI 10.1161/01.CIR.0000091406.72832.11
   Saltiel AR, 2001, NATURE, V414, P799, DOI 10.1038/414799a
   Sandu OA, 2000, DIABETES, V49, P2178, DOI 10.2337/diabetes.49.12.2178
   Steinberg HO, 1996, J CLIN INVEST, V97, P2601, DOI 10.1172/JCI118709
   TADDEI S, 1995, CIRCULATION, V92, P2911, DOI 10.1161/01.CIR.92.10.2911
   Tesauro M, 2005, CIRCULATION, V112, P2986, DOI 10.1161/CIRCULATIONAHA.105.553883
   TIRUPATTUR PR, 1993, AM J HYPERTENS, V6, P626, DOI 10.1093/ajh/6.7.626
   Westerbacka J, 2004, ARTERIOSCL THROM VAS, V24, P320, DOI 10.1161/01.ATV.0000110444.59568.56
   Yudkin JS, 2005, LANCET, V365, P1817, DOI 10.1016/S0140-6736(05)66585-3
   Zeng GY, 2000, CIRCULATION, V101, P1539, DOI 10.1161/01.CIR.101.13.1539
   Zhang L, 2003, AM J PHYSIOL-ENDOC M, V285, pE654, DOI 10.1152/ajpendo.00119.2003
NR 27
TC 49
Z9 50
U1 0
U2 1
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD DEC
PY 2010
VL 299
IS 6
BP E947
EP E952
DI 10.1152/ajpendo.00426.2010
PG 6
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 700CN
UT WOS:000285710400010
PM 20923961
DA 2025-06-11
ER

PT J
AU Mohamed, SM
   Shalaby, MA
   El-Shiekh, RA
   Bakr, AF
   Kamel, S
   Emam, SR
   El-Banna, HA
AF Mohamed, Salma Mostafa
   Shalaby, Mostafa Abbas
   El-Shiekh, Riham A.
   Bakr, Alaa F.
   Kamel, Shaimaa
   Emam, Shimaa R.
   El-Banna, Hossny A.
TI Maca roots: A potential therapeutic in the management of metabolic
   disorders through the modulation of metabolic biochemical markers in
   rats fed high-fat high-carbohydrate diet
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Maca roots; Metabolic syndrome; Insulin resistance; Lipid profile; Blood
   glucose; HFCD/STZ rat model
ID EXTRACT
AB Ethnopharmacological relevance: Maca root (Lepidium meyenii Walp.) is a Peruvian plant of the Brassicaceae family. Maca roots are popular food supplements used to treat a variety of ailments described traditionally as enhancing metabolic and health conditions. Aim of the study: Metabolic syndrome (MetS) has been the real scourge globally, affecting more than one-fourth of the global population. MetS causes the development of multi-organ illnesses, including altered blood cholesterol and sugar levels, oxidative stress, and hypertension. This study evaluated maca root total methanolic extract (MTE) as a potential nutraceutical to manage the complications of MetS. Materials and methods: After the first 4 weeks of a high-fat high-carbohydrate diet (HFCD), streptozotocin (STZ) was injected in Wistar rats to induce the MetS model. Animals were treated orally with MTE at 100 mg/kg and 300 mg/kg for 4 weeks compared to metformin at 200 mg/kg after confirmation of diabetes. Results: One month of MTE supplementation in HFCD-fed rats remarkably decreased the elevation of blood glucose and lipids, improved liver function and insulin resistance, additionally it successfully restored the state of inflammatory and oxidative stress. The extract was standardized to contain total phenolics equal to 24.45 +/- 0.96 mu g Gallic acid/mg extract. Conclusions: Our findings suggest that MTE improves MetS by reducing hyperglycemia, hyperlipidemia, inflammation, and oxidative stress. While also improving beta cell secretory functions, implying that MTE could be used as a balancing drug in the prevention and treatment of metabolic abnormalities linked to type 2 diabetes.
C1 [Mohamed, Salma Mostafa; Shalaby, Mostafa Abbas; Emam, Shimaa R.; El-Banna, Hossny A.] Cairo Univ, Fac Vet Med, Dept Pharmacol, 12211 Giza, Egypt.
   [El-Shiekh, Riham A.] Cairo Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11562, Egypt.
   [Bakr, Alaa F.] Cairo Univ, Fac Vet Med, Dept Pathol, Cairo, Egypt.
   [Kamel, Shaimaa] Cairo Univ, Fac Vet Med, Dept Biochem & Mol Biol, Giza 12211, Egypt.
C3 Egyptian Knowledge Bank (EKB); Cairo University; Egyptian Knowledge Bank
   (EKB); Cairo University; Egyptian Knowledge Bank (EKB); Cairo
   University; Egyptian Knowledge Bank (EKB); Cairo University
RP El-Shiekh, RA (corresponding author), Cairo Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11562, Egypt.
EM Salmamostafa14@hotmail.com; m_shalaby_1@outlook.com;
   riham.adel@pharma.cu.edu.eg; alaa.fouad1991@gmail.com;
   shaimaa.kamel@cu.edu.eg; shimaaramadan@cu.edu.eg; drelbanna3@cu.edu.eg
RI Shalaby, Drmostafa/S-9823-2019; R Emam, Shimaa/LQK-0944-2024; El Banna,
   Hossny/AAV-5079-2020; Kamel, Shaimaa/T-6308-2019
OI Ramadan, Shimaa/0000-0003-3860-3571; , Shaimaa/0000-0002-7414-3034;
   ElBanna, Hossny/0000-0003-4476-7775
CR AEBI H, 1984, METHOD ENZYMOL, V105, P121
   Ahire E.D., 2023, The Metabolic Syndrome: A Concerning Area for Future Research, the Metabolic Syndrome, P231
   Ahmed SMU, 2017, BBA-MOL BASIS DIS, V1863, P585, DOI 10.1016/j.bbadis.2016.11.005
   Ahmed YH, 2022, CELL TISSUE RES, V388, P149, DOI 10.1007/s00441-022-03581-5
   Ali N.B., 2023, J. Ethnopharmacol., V319, DOI [10.1016/j. jep.2023.117115, DOI 10.1016/J.JEP.2023.117115]
   Ashour RMS, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-45499-0
   Atta AH, 2023, ENVIRON SCI POLLUT R, V30, P83421, DOI 10.1007/s11356-023-28146-z
   Attard E, 2013, CENT EUR J BIOL, V8, P48, DOI 10.2478/s11535-012-0107-3
   Bashir DW, 2021, NEUROTOXICOLOGY, V86, P37, DOI 10.1016/j.neuro.2021.06.006
   Bawish BM, 2023, INFLAMMOPHARMACOLOGY, V31, P3183, DOI 10.1007/s10787-023-01205-0
   Beharry S, 2018, J ETHNOPHARMACOL, V211, P126, DOI 10.1016/j.jep.2017.08.003
   Birulina JG, 2020, BYULLETEN SIB MED, V19, P14, DOI 10.20538/1682-0363-2020-4-14-20
   Casacchia T, 2019, EUR J NUTR, V58, P965, DOI 10.1007/s00394-018-1609-1
   Chen HW, 2019, J FOOD DRUG ANAL, V27, P736, DOI 10.1016/j.jfda.2018.12.009
   Chen R, 2021, PHYTOTHER RES, V35, P6706, DOI 10.1002/ptr.7257
   Chen WB, 2022, FOOD FUNCT, V13, P3441, DOI [10.1039/d1fo02659c, 10.1039/D1FO02659C]
   Choi J.-G., 2011, Evid Based Complement Alternat Med
   Peres NSL, 2020, FOOD FUNCT, V11, P83, DOI 10.1039/c9fo02732g
   De B, 2019, SN APPL SCI, V1, DOI 10.1007/s42452-019-1518-9
   Dzieciol M, 2023, APPL SCI-BASEL, V13, DOI 10.3390/app13084827
   El Kasas AH, 2022, MOL BIOL REP, V49, P3849, DOI 10.1007/s11033-022-07232-4
   El-Shiekh R.A., 2023, Food Chem. Adv., V3
   El-Shiekh RA, 2019, J ETHNOPHARMACOL, V238, DOI 10.1016/j.jep.2019.111893
   Elkhateeb A, 2019, MED CHEM RES, V28, P505, DOI 10.1007/s00044-019-02309-5
   Elleithy EMM, 2023, TROP ANIM HEALTH PRO, V55, DOI 10.1007/s11250-023-03453-2
   ELLMAN GL, 1959, ARCH BIOCHEM BIOPHYS, V82, P70, DOI 10.1016/0003-9861(59)90090-6
   Finicelli M, 2019, J CELL PHYSIOL, V234, P5807, DOI 10.1002/jcp.27506
   Francini-Pesenti F, 2019, DIABET METAB SYND OB, V12, P1987, DOI 10.2147/DMSO.S214550
   Friedman SL, 2018, NAT MED, V24, P908, DOI 10.1038/s41591-018-0104-9
   Gad MZ, 2010, PAK J PHARM SCI, V23, P305
   Gencoglu H, 2023, ARCH PHYSIOL BIOCHEM, V129, P323, DOI 10.1080/13813455.2020.1821064
   Gonzales GF, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/193496
   Hassan N, 2023, DRUG CHEM TOXICOL, V46, P357, DOI 10.1080/01480545.2022.2039180
   Hassanen EI, 2023, TOXICOLOGY, V484, DOI 10.1016/j.tox.2022.153410
   Huang YP, 2022, ACS OMEGA, DOI 10.1021/acsomega.2c01541
   Hussien Ahmed, 2023, Journal of Advanced Veterinary Research, V13, P94
   Ibrahim RM, 2022, ACS OMEGA, V7, P17339, DOI 10.1021/acsomega.2c01342
   Kang CC, 2018, INT J BIOL MACROMOL, V107, P2611, DOI 10.1016/j.ijbiomac.2017.10.139
   Kumari R, 2019, DIABETES METAB SYND, V13, P2409, DOI 10.1016/j.dsx.2019.06.005
   Li AM, 2021, FOOD SCI NUTR, V9, P2894, DOI 10.1002/fsn3.2246
   Li SR, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21186973
   Miao HuiYing Miao HuiYing, 2012, Journal of Food Safety and Quality, V3, P367
   Nammi S, 2009, BASIC CLIN PHARMACOL, V104, P366, DOI 10.1111/j.1742-7843.2008.00362.x
   Nimrouzi M, 2020, J ETHNOPHARMACOL, V254, DOI 10.1016/j.jep.2020.112721
   Noshy PA, 2023, NEUROTOXICOLOGY, V95, P193, DOI 10.1016/j.neuro.2023.02.005
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   Orhan C, 2022, J FOOD BIOCHEM, V46, DOI 10.1111/jfbc.14159
   Pakdeechote P, 2014, NUTRIENTS, V6, P355, DOI 10.3390/nu6010355
   Prasatthong P, 2021, EUR J NUTR, V60, P833, DOI 10.1007/s00394-020-02291-4
   Radi MH, 2024, INFLAMMOPHARMACOLOGY, V32, P461, DOI 10.1007/s10787-023-01298-7
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Suman R.K., 2016, Int. J. Biomed. Res., V7, P55
   Tonelli C, 2018, ANTIOXID REDOX SIGN, V29, P1727, DOI 10.1089/ars.2017.7342
   Wan WT, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00333
   Wu X, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/3585394
   Ybañez-Julca RO, 2022, PLANT FOOD HUM NUTR, V77, P460, DOI 10.1007/s11130-022-01000-2
   Yi F, 2016, CHIN MED-UK, V11, DOI 10.1186/s13020-016-0112-y
   Zhao LL, 2021, FISH SHELLFISH IMMUN, V119, P308, DOI 10.1016/j.fsi.2021.10.019
   Zheng W, 2018, MEDIAT INFLAMM, V2018, DOI 10.1155/2018/8982756
   Zhu HK, 2022, EUR J PHARMACOL, V917, DOI 10.1016/j.ejphar.2022.174758
NR 60
TC 6
Z9 6
U1 1
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD MAR 1
PY 2024
VL 321
AR 117533
DI 10.1016/j.jep.2023.117533
EA DEC 2023
PG 14
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA DP2Q7
UT WOS:001133198600001
PM 38056538
DA 2025-06-11
ER

PT J
AU Zhu, Y
   Huang, YB
   Santos, HO
   de Oliveira, CVC
   Zhou, H
   Tang, NI
AF Zhu, Ying
   Huang, Yubing
   Santos, Heitor O.
   de Oliveira, Caio V. C.
   Zhou, Hui
   Tang, Nie
TI Effects of purslane supplementation on C-reactive protein levels and
   biomarkers of oxidative stress as marks for metabolic syndrome: A
   systematic review and meta-analysis of randomized controlled trials
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE C-reactive protein; endocrine syndrome; meta-analysis; oxidative stress;
   Portulaca oleracea; purslane
ID PORTULACA-OLERACEA L.; TYPE-2 DIABETES-MELLITUS; SEEDS
AB The antioxidant and antiinflammatory properties of purslane (Portulaca oleracea L.) are known in preclinical studies but further examination is needed to expand their potential into the clinical scenario. A systematic review and meta-analysis of randomized controlled trials were performed to elucidate the effects of purslane supplementation on C-reactive protein (CRP) levels and biomarkers of oxidative stress in metabolic syndrome, its related complications, and other diseases. PubMed/MEDLINE, Web of Science, SCOPUS, and Embase were the databases searched. Heterogeneity was examined using the I-squared (I-2) statistic, in which the source of heterogeneity was determined if the I-2-value was >50%. After all the screening processes, 10 studies met the eligibility criteria and were analyzed. Following purslane supplementation, CRP levels decreased significantly (weighted mean difference [WMD]: -0.33 mg/dl, 95% confidence interval [CI]: -0.66, -0.004, p = .047) but with significant heterogeneity (I-2 = 87.4%, p = .001). Purslane supplementation did not significantly change serum levels of malondialdehyde (MDA) (WMD: -0.353 mu m/L; 95% CI: -0.920, 0.213; I-2 = 50.7%), total antioxidant capacity (TAC) (WMD: 0.090 mm/L, 95% CI: -0.081, 0.262; I-2 = 47.1%), and superoxide dismutase (SOD) (WMD: 6.54 U/ml, 95% CI: -22.150, 35.236; I-2 = 70.7%). Thus, this meta-analysis showed a positive effect of purslane supplementation as a tool to decrease CRP levels, but not to MDA, TAC, and SOD levels.
C1 [Zhu, Ying; Zhou, Hui; Tang, Nie] Univ Elect Sci & Technol China, Chinese Acad Sci, Sichuan Translat Med Res Hosp, Sichuan Prov Peoples Hosp,Dept Endocrinol, Chengdu 610072, Peoples R China.
   [Huang, Yubing] Hainan Med Univ, Hainan Affiliated Hosp, Hainan Gen Hosp, Dept Cardiol, Haikou, Hainan, Peoples R China.
   [Santos, Heitor O.] Fed Univ Uberlandia UFU, Sch Med, Uberlandia, MG, Brazil.
   [de Oliveira, Caio V. C.] Ctr Univ Facisa Unifacisa, Campina Grande, Paraiba, Brazil.
C3 Sichuan Provincial People's Hospital; Chinese Academy of Sciences;
   University of Electronic Science & Technology of China; Hainan Medical
   University; Universidade Federal de Uberlandia
RP Zhou, H; Tang, NI (corresponding author), Univ Elect Sci & Technol China, Chinese Acad Sci, Sichuan Translat Med Res Hosp, Sichuan Prov Peoples Hosp,Dept Endocrinol, Chengdu 610072, Peoples R China.
EM fpxzzhou@163.com; 39tangdawn@sina.com
FU Sichuan Provincial Science and Technology Department [2017FZ0039];
   Sichuan Academy of Medical Sciences/Sichuan Provincial People's Hospital
   [2021QN1]
FX This study was supported by Sichuan Provincial Science and Technology
   Department (No. 2017FZ0039), and Sichuan Academy of Medical
   Sciences/Sichuan Provincial People's Hospital (No. 2021QN1).
CR Abdalla Hussein M Jr, 2010, Malays J Nutr, V16, P419
   Alam MA, 2014, MOL BIOL REP, V41, P7395, DOI 10.1007/s11033-014-3628-1
   Ansari Samani R, 2013, SJKU, V18, P28
   Asbaghi O, 2019, COMPLEMENT THER MED, V46, P210, DOI 10.1016/j.ctim.2019.08.019
   Babakhanian M, 2016, IRAN J PSYCHIATRY BE, V10, DOI 10.17795/ijpbs-2026
   Bataille P., 2001, MED NUTR FRANCE, V3, P103
   Bedakhanian M., 2017, J HLTH SYSTEM RES, V12, P1
   Besong S.A., 2011, International Journal of Nutrition and Metabolism, V3, P43
   Bjorklund G, 2017, NUTRITION, V33, P311, DOI 10.1016/j.nut.2016.07.018
   Boncler M, 2019, MOLECULES, V24, DOI 10.3390/molecules24112062
   Califf RM, 2018, EXP BIOL MED, V243, P213, DOI 10.1177/1535370217750088
   Cals JWL, 2011, J EVAL CLIN PRACT, V17, P1059, DOI 10.1111/j.1365-2753.2010.01472.x
   Dehghan F, 2016, SCI REP-UK, V6, DOI 10.1038/srep25139
   Dkhil MA, 2011, J MED PLANTS RES, V5, P1589
   Egger M, 1997, BMJ-BRIT MED J, V315, P629, DOI 10.1136/bmj.315.7109.629
   El-Sayed MIK, 2011, J ETHNOPHARMACOL, V137, P643, DOI 10.1016/j.jep.2011.06.020
   Esmaillzadeh A, 2015, J RES MED SCI, V20, P47
   Fakoori Jouibari M., 2014, SSU J, V22, P928
   Farzanegi P., 2014, Res. Mol. Med., V2, P34, DOI 10.18869/acadpub.rmm.2.2.34
   Farzanegi P., 2014, MED LAB J, V8, P11
   Frijhoff J, 2015, ANTIOXID REDOX SIGN, V23, P1144, DOI 10.1089/ars.2015.6317
   Gheflati A, 2019, PHYTOTHER RES, V33, P1501, DOI 10.1002/ptr.6342
   Guzik TJ, 2003, J PHYSIOL PHARMACOL, V54, P469
   Hadi A, 2019, PHYTOTHER RES, V33, P3, DOI 10.1002/ptr.6203
   Higgins J, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.ED000049
   Ho E, 2013, REDOX BIOL, V1, P483, DOI 10.1016/j.redox.2013.07.006
   Hozo Stela Pudar, 2005, BMC Med Res Methodol, V5, P13, DOI 10.1186/1471-2288-5-13
   Hussein Mohammed A, 2010, Saudi Pharm J, V18, P27, DOI 10.1016/j.jsps.2009.12.002
   Iranshahy M, 2017, J ETHNOPHARMACOL, V205, P158, DOI 10.1016/j.jep.2017.05.004
   Izzo AA, 2016, PHYTOTHER RES, V30, P691, DOI 10.1002/ptr.5591
   Jackson D, 2010, STAT MED, V29, P1282, DOI 10.1002/sim.3602
   Karimi A, 2018, EFFECT PURSLANE PORT
   Lagrand WK, 1999, CIRCULATION, V100, P96, DOI 10.1161/01.CIR.100.1.96
   Lim YY, 2007, FOOD CHEM, V103, P734, DOI 10.1016/j.foodchem.2006.09.025
   Lou XJ, 2011, AFR J PHARM PHARMACO, V5, P381
   Luan YY, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01302
   Miao LC, 2019, FOOD CHEM, V290, P239, DOI 10.1016/j.foodchem.2019.04.005
   Miladipour AH, 2012, IRAN J KIDNEY DIS, V6, P33
   Mohammadi H, 2019, J MED PLANTS, V2, P255, DOI DOI 10.29252/JMP.4.72.255
   Mohammadzadeh M., 2016, BRAZ J ORAL SCI, V15, P234
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Nehring S.M., 2017, C REACTIVE PROTEIN C
   Nemzer B, 2020, FOOD CHEM, V320, DOI 10.1016/j.foodchem.2020.126621
   Palaniswamy UR, 2004, SCI HORTIC-AMSTERDAM, V102, P267, DOI 10.1016/j.scienta.2004.01.006
   Papoli M, 2019, PROG NUTR, V21, P329, DOI 10.23751/pn.v21i1-S.6210
   Parvin N., 2013, EUR PSYCHIAT, V28, P1
   Rafiei R., 2014, ADV BIOMED RES-INDIA, V29, P235
   Reid D.P., 1987, CHINESE HERBAL MED H
   Vahedi Ghadikolaei M., 2015, EFFECT 8 WEEKS RESIS
   Zakizadeh E, 2015, INT J PREVENTIVE MED, V6, DOI 10.4103/2008-7802.166505
   Zheng GY, 2014, PHYTOCHEM LETT, V7, P77, DOI 10.1016/j.phytol.2013.10.005
   Zhou YX, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/925631
NR 52
TC 14
Z9 14
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD OCT
PY 2021
VL 35
IS 10
BP 5477
EP 5486
DI 10.1002/ptr.7182
EA JUN 2021
PG 10
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA WL6EZ
UT WOS:000659375700001
PM 34109686
DA 2025-06-11
ER

PT J
AU Jialal, I
   Devaraj, S
   Adams-Huet, B
   Chen, XP
   Kaur, H
AF Jialal, Ishwarlal
   Devaraj, Sridevi
   Adams-Huet, Beverley
   Chen, Xinpu
   Kaur, Harmeet
TI Increased Cellular and Circulating Biomarkers of Oxidative Stress in
   Nascent Metabolic Syndrome
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; INSULIN-RESISTANCE; DIABETIC-PATIENTS; OBESITY;
   COMPLICATIONS; NITROTYROSINE; MITOCHONDRIA; INFLAMMATION; ASSOCIATION;
   ACTIVATION
AB Context: Metabolic syndrome (MetS) confers a greater risk for both cardiovascular disease (CVD) and diabetes. Oxidative stress (OS) could contribute to this excess risk. However, there are few data examining both cellular and circulating biomarkers of OS in MetS uncomplicated by diabetes and CVD.
   Objective: The aim of the study was to evaluate both cellular and circulating biomarkers of OS in MetS uncomplicated by diabetes or CVD.
   Design and Setting: At an academic medical center, we compared MetS (n = 43) vs. control subjects (n = 33). Fasting blood was collected for monocyte isolation and assay of OS biomarkers.
   Main Outcome: Monocyte nicotinamide adenine dinucleotide phosphate oxidase activity (p22 phox and p47), superoxide anion release, oxidized-low-density lipoprotein (Ox-LDL), nitrotyrosine, and nuclear factor erythroid 2-related factor were measured.
   Results: There was significantly increased release of superoxide from the monocytes (basal and after activation) of MetS compared with controls adjusted for body mass index. Body mass index-adjusted plasma levels of Ox-LDL and nitrotyrosine were significantly increased in MetS. There was a linear trend between biomarkers of oxidative stress and increasing number of features of MetS. Also, there was a significant increase in nicotinamide adenine dinucleotide phosphate oxidase membrane expression of p22 phox and p47 phox in MetS. The major cellular antioxidant defense, nuclear factor erythroid 2-related factor was significantly decreased. There were significant correlations between homeostasis model assessment insulin resistance index and both Ox-LDL and nitrotyrosine and superoxide and Ox-LDL.
   Conclusions: Collectively, nascent MetS is associated with increased OS as evidenced by both circulating and cellular biomarkers, and this could contribute to the risk for both diabetes and CVD. (J Clin Endocrinol Metab 97: E1844-E1850, 2012)
C1 [Jialal, Ishwarlal] Univ Calif Davis, Med Ctr, Lab Atherosclerosis & Metab Res, Dept Pathol & Lab Med, Sacramento, CA 95817 USA.
   [Jialal, Ishwarlal] Vet Affairs Med Ctr, Mather, CA 95655 USA.
   [Devaraj, Sridevi; Chen, Xinpu] Texas Childrens Hosp, Dept Pathol, Houston, TX 77030 USA.
   Baylor Coll Med, Houston, TX 77030 USA.
   [Adams-Huet, Beverley] Univ Texas SW Med Ctr Dallas, Dept Biostat, Dallas, TX 75390 USA.
C3 University of California System; University of California Davis; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Baylor College of Medicine; Baylor College Medical Hospital; Baylor
   College of Medicine; University of Texas System; University of Texas
   Southwestern Medical Center Dallas
RP Jialal, I (corresponding author), Univ Calif Davis, Med Ctr, Lab Atherosclerosis & Metab Res, Dept Pathol & Lab Med, 4635 2nd Ave,Res 1 Bldg,Room 3000, Sacramento, CA 95817 USA.
EM ijialal@ucdavis.edu
RI Jialal, Ishwarlal/AAG-6218-2019; KAUR, HARMEET/C-7765-2012
FU American Diabetes Association
FX This work was supported by a grant from the American Diabetes
   Association (to I. J.).
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Avogaro A, 2003, J CLIN ENDOCR METAB, V88, P1753, DOI 10.1210/jc.2002-021025
   Bokoch GM, 2003, TRENDS BIOCHEM SCI, V28, P502, DOI 10.1016/S0968-0004(03)00194-4
   Bremer AA, 2011, J CLIN ENDOCR METAB, V96, pE1782, DOI 10.1210/jc.2011-1577
   Ceriello A, 2001, DIABETOLOGIA, V44, P834
   Cheng XH, 2011, ANTIOXID REDOX SIGN, V14, P469, DOI 10.1089/ars.2010.3283
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   Dandona P, 1996, LANCET, V347, P444, DOI 10.1016/S0140-6736(96)90013-6
   Dasu MR, 2008, DIABETES, V57, P3090, DOI 10.2337/db08-0564
   Delbosc S, 2005, ATHEROSCLEROSIS, V179, P43, DOI 10.1016/j.atherosclerosis.2004.10.018
   Devaraj S, 2000, CIRCULATION, V102, P191, DOI 10.1161/01.CIR.102.2.191
   Devaraj S, 2006, J CLIN ENDOCR METAB, V91, P4489, DOI 10.1210/jc.2006-0299
   Devaraj S, 2010, CURR ATHEROSCLER REP, V12, P110, DOI 10.1007/s11883-010-0098-3
   Dikalov S, 2011, FREE RADICAL BIO MED, V51, P1289, DOI 10.1016/j.freeradbiomed.2011.06.033
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Esposito K, 2006, J ENDOCRINOL INVEST, V29, P791, DOI 10.1007/BF03347372
   Fortuño A, 2006, DIABETES, V55, P209, DOI 10.2337/diabetes.55.1.209
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Ghanim H, 2011, J CLIN ENDOCR METAB, V96, P1409, DOI 10.1210/jc.2010-1812
   Giacco F, 2010, CIRC RES, V107, P1058, DOI 10.1161/CIRCRESAHA.110.223545
   Heiss EH, 2009, J BIOL CHEM, V284, P31579, DOI 10.1074/jbc.M109.009175
   Holvoet P, 2008, JAMA-J AM MED ASSOC, V299, P2287, DOI 10.1001/jama.299.19.2287
   Holvoet P, 2008, FUTURE LIPIDOL, V3, P637, DOI 10.2217/17460875.3.6.637
   Huang PL, 2005, CIRC RES, V96, P1129, DOI 10.1161/01.RES.0000170705.56583.45
   Jialal I, 2010, ATHEROSCLEROSIS, V211, P297, DOI 10.1016/j.atherosclerosis.2010.01.036
   Jialal I, 2012, DIABETES CARE, V35, P900, DOI 10.2337/dc11-2375
   Kang KW, 2005, ANTIOXID REDOX SIGN, V7, P1664, DOI 10.1089/ars.2005.7.1664
   Meisinger C, 2005, CIRCULATION, V112, P651, DOI 10.1161/CIRCULATIONAHA.104.529297
   Pi JB, 2010, TOXICOL APPL PHARM, V244, P77, DOI 10.1016/j.taap.2009.05.025
   Shishehbor MH, 2003, JAMA-J AM MED ASSOC, V289, P1675, DOI 10.1001/jama.289.13.1675
   Singh U, 2008, AM J CARDIOL, V102, P321, DOI 10.1016/j.amjcard.2008.03.057
   Sjogren P, 2005, ARTERIOSCL THROM VAS, V25, P2580, DOI 10.1161/01.ATV.0000190675.08857.3d
   Tan Y, 2011, DIABETES, V60, P625, DOI 10.2337/db10-1164
   Weseler AR, 2010, CURR HYPERTENS REP, V12, P154, DOI 10.1007/s11906-010-0103-9
   Whaley-Connell A, 2011, REV CARDIOVASC MED, V12, P21, DOI 10.3909/ricm0555
   Xue MZ, 2008, DIABETES, V57, P2809, DOI 10.2337/db06-1003
   Yamaguchi Y, 2006, NITRIC OXIDE-BIOL CH, V15, P380, DOI 10.1016/j.niox.2006.04.264
   Zalba G, 2005, ARTERIOSCL THROM VAS, V25, P1452, DOI 10.1161/01.ATV.0000168411.72483.08
NR 38
TC 80
Z9 85
U1 0
U2 4
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD OCT 1
PY 2012
VL 97
IS 10
BP E1844
EP E1850
DI 10.1210/jc.2012-2498
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 018MH
UT WOS:000309664400003
PM 22872691
OA Bronze
DA 2025-06-11
ER

PT J
AU Sandstedt, M
   Bergfeldt, L
   Sandstedt, J
   Lundqvist, A
   Fryk, E
   Jansson, PA
   Bergström, G
   Hultén, LM
AF Sandstedt, Mikael
   Bergfeldt, Lennart
   Sandstedt, Joakim
   Lundqvist, Annika
   Fryk, Emanuel
   Jansson, Per-Anders
   Bergstrom, Goran
   Hulten, Lillemor Mattsson
TI Wide QRS-T angles are associated with markers of increased inflammatory
   activity independently of hypertension and diabetes
SO ANNALS OF NONINVASIVE ELECTROCARDIOLOGY
LA English
DT Article
DE cytokines; inflammation; QRS-T angles; sudden cardiac death;
   vectorcardiography; white blood cells
ID SUDDEN CARDIAC DEATH; C-REACTIVE PROTEIN; HEART-FAILURE;
   MYOCARDIAL-INFARCTION; ESTIMATING EQUATION; MYOCYTES; RISK;
   OVEREXPRESSION; PREDICTORS; CELLS
AB Background Wide QRS-T angles and inflammatory activity are markers of future cardiovascular events including sudden cardiac death (SCD). The association between wide QRS-T angles and inflammatory activation is however not fully understood. Methods 1,094 study participants of both sexes, 50-64 years old, were included from a randomly selected population-based cohort as a part of the Swedish CArdioPulmonary bioImage Study (SCAPIS) pilot study. Serum samples were analyzed for markers of inflammation, cardiac wall stress/injury, and the metabolic syndrome. Wide QRS-T angles were defined using Frank vectorcardiography. Variables were analyzed through unsupervised principal component analysis (PCA) as well as Orthogonal Projections to Latent Structures (OPLS) modeling. In addition, a subset of study participants was analyzed in a post hoc matched group design. Results Wide QRS-T angles correlated positively with markers of inflammation, cardiac wall stress/injury, the metabolic syndrome, and male sex in both PCA and OPLS models. In the matched post hoc analysis, participants with wide QRS-T angles had significantly higher counts of white blood cells (WBC) and neutrophils in comparison with matched controls. WBC as well as the number of neutrophils, monocytes, basophils, eosinophils and levels of C-reactive protein, IL-1, IL-4, IL-6, TNF-alpha, and NT-pro-BNP were also significantly higher in comparison with healthy controls. Conclusions Markers of inflammatory activation and cardiac injury/wall stress were significantly higher in the presence of wide QRS-T angles. These results corroborate an association between abnormal electrophysiological function and inflammatory activation and may have implications for the prediction of SCD.
C1 [Sandstedt, Mikael; Sandstedt, Joakim; Hulten, Lillemor Mattsson] Sahlgrens Univ Hosp, Dept Clin Chem, Reg Vastra Gotaland, Gothenburg, Sweden.
   [Sandstedt, Mikael; Sandstedt, Joakim] Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Lab Med, Bruna Straket 16, S-41345 Gothenburg, Sweden.
   [Bergfeldt, Lennart] Sahlgrens Univ Hosp, Dept Cardiol, Reg Vastra Gotaland, Gothenburg, Sweden.
   [Bergfeldt, Lennart; Lundqvist, Annika; Fryk, Emanuel; Jansson, Per-Anders; Bergstrom, Goran; Hulten, Lillemor Mattsson] Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med, Gothenburg, Sweden.
   [Jansson, Per-Anders] Sahlgrens Univ Hosp, Gothia Forum, Reg Vastra Gotaland, Gothenburg, Sweden.
C3 Sahlgrenska University Hospital; University of Gothenburg; Sahlgrenska
   University Hospital; University of Gothenburg; Sahlgrenska University
   Hospital
RP Sandstedt, M (corresponding author), Sahlgrens Univ Hosp, Dept Clin Chem, Reg Vastra Gotaland, Gothenburg, Sweden.; Sandstedt, M (corresponding author), Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Lab Med, Bruna Straket 16, S-41345 Gothenburg, Sweden.
EM mikael.sandstedt@gu.se
RI Sandstedt, Mikael/GRO-7230-2022
OI Bergstrom, Goran/0000-0003-4289-5722
FU Hjart-Lungfonden [20130314, 20190214]; VINNOVA; Knut och Alice
   Wallenbergs Stiftelse; Swedish government [ALFGBG-722431, ALFGBG-74560,
   ALFGBG-813211]; Vetenskapsradet
FX Hjart-Lungfonden, Grant/Award Number: 20130314 and 20190214; VINNOVA;
   Knut och Alice Wallenbergs Stiftelse; Swedish state under the agreement
   between the Swedish government and the county councils, the
   ALF-agreement, Grant/Award Number: ALFGBG-722431, ALFGBG-74560 and
   ALFGBG-813211; Vetenskapsradet
CR Adabi Elham, 2017, Iranian Biomedical Journal, V21, P77, DOI 10.18869/acadpub.ibj.21.2.77
   Al-Khatib SM, 2018, CIRCULATION, V138, pE210, DOI [10.1161/CIR.0000000000000548, 10.1161/CIR.0000000000000549]
   Albert CM, 2002, CIRCULATION, V105, P2595, DOI 10.1161/01.CIR.0000017493.03108.1C
   Bansal SS, 2017, CIRC-HEART FAIL, V10, DOI 10.1161/CIRCHEARTFAILURE.116.003688
   Barisione C, 2010, DIS MARKERS, V28, P115, DOI [10.1155/2010/236405, 10.3233/DMA-2010-0691]
   Baum JR, 2012, AM J PHYSIOL-HEART C, V302, pH790, DOI 10.1152/ajpheart.00498.2011
   Bergström G, 2015, J INTERN MED, V278, P645, DOI 10.1111/joim.12384
   Delhey L, 2020, ANN NONINVAS ELECTRO, V25, DOI 10.1111/anec.12678
   Empana JP, 2010, ARTERIOSCL THROM VAS, V30, P2047, DOI 10.1161/ATVBAHA.110.208785
   Fernández-Velasco M, 2007, AM J PHYSIOL-HEART C, V293, pH238, DOI 10.1152/ajpheart.01122.2006
   Fontes JA, 2015, CYTOKINE, V74, P62, DOI 10.1016/j.cyto.2014.12.024
   FRANK E, 1956, CIRCULATION, V13, P737, DOI 10.1161/01.CIR.13.5.737
   Grubb A, 2014, CLIN CHEM, V60, P974, DOI 10.1373/clinchem.2013.220707
   Gummesson A, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0202666
   Hasselqvist-Ax I, 2015, NEW ENGL J MED, V372, P2307, DOI 10.1056/NEJMoa1405796
   Huikuri HV, 2003, J AM COLL CARDIOL, V42, P652, DOI 10.1016/S0735-1097(03)00783-6
   Hussein AA, 2013, HEART RHYTHM, V10, P1425, DOI 10.1016/j.hrthm.2013.07.004
   Jeppsson JO, 2002, CLIN CHEM LAB MED, V40, P78, DOI 10.1515/CCLM.2002.016
   Korngold EC, 2009, CIRCULATION, V119, P2868, DOI 10.1161/CIRCULATIONAHA.108.832576
   Kucharska-Newton AM, 2009, ARTERIOSCL THROM VAS, V29, P2182, DOI 10.1161/ATVBAHA.109.192740
   Kuribayashi T, 2015, INFLAMMATION, V38, P1401, DOI 10.1007/s10753-015-0114-4
   Lingman M, 2016, INT J CARDIOL, V218, P1, DOI 10.1016/j.ijcard.2016.05.005
   Liu Z, 2019, HEART RHYTHM, V16, P1080, DOI 10.1016/j.hrthm.2019.01.013
   Nyman U, 2014, CLIN CHEM LAB MED, V52, P815, DOI 10.1515/cclm-2013-0741
   Oehler A, 2014, ANN NONINVAS ELECTRO, V19, P534, DOI 10.1111/anec.12206
   Okamoto N, 2014, INT HEART J, V55, P271, DOI 10.1536/ihj.13-343
   Parekh RS, 2008, KIDNEY INT, V74, P1335, DOI 10.1038/ki.2008.449
   Petkova-Kirova PS, 2006, AM J PHYSIOL-HEART C, V290, pH2098, DOI 10.1152/ajpheart.00097.2005
   Schreurs CA, 2010, J ELECTROCARDIOL, V43, P294, DOI 10.1016/j.jelectrocard.2010.03.009
   Singh MV, 2011, J MOL MED, V89, P537, DOI 10.1007/s00109-011-0727-5
   Tsujioka H, 2009, J AM COLL CARDIOL, V54, P130, DOI 10.1016/j.jacc.2009.04.021
   Voulgari C, 2013, CURR CARDIOL REV, V9, P197, DOI 10.2174/1573403X113099990031
   Voulgari C, 2010, METABOLISM, V59, P159, DOI 10.1016/j.metabol.2009.06.028
   Waks JW, 2016, CIRCULATION, V133, P2222, DOI 10.1161/CIRCULATIONAHA.116.021306
   Weirather J, 2014, CIRC RES, V115, P55, DOI 10.1161/CIRCRESAHA.115.303895
   Whang W, 2012, AM J CARDIOL, V109, P981, DOI 10.1016/j.amjcard.2011.11.027
   Yamazaki T, 2005, HEART RHYTHM, V2, P73, DOI 10.1016/j.hrthm.2004.10.040
   Zheng ZJ, 2001, CIRCULATION, V104, P2158, DOI 10.1161/hc4301.098254
NR 38
TC 5
Z9 5
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1082-720X
EI 1542-474X
J9 ANN NONINVAS ELECTRO
JI Ann. Noninvasive Electrocardiol.
PD NOV
PY 2020
VL 25
IS 6
AR e12781
DI 10.1111/anec.12781
EA JUL 2020
PG 14
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA PA5DZ
UT WOS:000546680100001
PM 32638456
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Fernandes, IA
   Sales, ARK
   Rocha, NG
   Silva, BM
   Vianna, LC
   da Nóbrega, ACL
AF Fernandes, Igor A.
   Sales, Allan R. K.
   Rocha, Natalia G.
   Silva, Bruno M.
   Vianna, Lauro C.
   da Nobrega, Antonio C. L.
TI Preserved flow-mediated dilation but delayed time-to-peak diameter in
   individuals with metabolic syndrome
SO CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING
LA English
DT Article
DE doppler; endothelial function; hyperaemia; shear stress; vascular
   reactivity
ID INCIDENT CARDIOVASCULAR EVENTS; ENDOTHELIAL FUNCTION; BRACHIAL-ARTERY;
   SHEAR-STRESS; DYSFUNCTION; RISK; ATHEROSCLEROSIS; DILATATION; HUMANS;
   POPULATION
AB Introduction: Inconsistent evidences of the metabolic syndrome (MetS) impact on vascular reactivity raise questions on flow-mediated dilation (FMD) discriminatory power for disturbances induced by this clustering of risk factors. Previous reports, however, suggest that covariates such as the follow-up of the artery diameter changes, the arterial size and shear stress affect FMD responses and consequently its discriminatory power for distinctive clinical profiles.
   Objective: To determine the impact of MetS on traditional, arterial size-and shear-rate-adjusted FMD, the follow-up-derived time-to-peak diameter (TP), as well as their power for discriminating subjects with this clustering of risk factors from a sample of healthy individuals.
   Methods: Twenty-one MetS and ten healthy subjects underwent an assessment of endothelial function via FMD.
   Results: Traditional and allometrically scaled FMD did not differ between groups (P>0.05) as well as the approach in which the covariate was the peak diameter shear rate. In the existence of MetS, TP was longer (67.7 +/- 16.4 s versus healthy 42.1 +/- 16.3 s, P = 0.001). ROC curve analysis indicated that TP (AUC = 0.871 [95% CI, 0.718-1.000]) had greater power of discrimination for MetS than FMD approaches. In addition, TP presented a moderate and significant association with sE-selectin (r = 0.458, P = 0.048).
   Conclusion: Time-to-peak diameter (TP) rather than FMD distinguished MetS from a healthy profile. Therefore, at least in subjects with MetS, TP may provide insights into the impact of this clustering of risk factors on the vascular phenotype.
C1 [Fernandes, Igor A.; Sales, Allan R. K.; Rocha, Natalia G.; Vianna, Lauro C.; da Nobrega, Antonio C. L.] Univ Fed Fluminense, Lab Exercise Sci, Dept Physiol & Pharmacol, BR-24210130 Niteroi, RJ, Brazil.
   [Silva, Bruno M.] Univ Fed Sao Paulo, Exercise Physiol Sect, Dept Physiol, Sao Paulo, Brazil.
C3 Universidade Federal Fluminense; Universidade Federal de Sao Paulo
   (UNIFESP)
RP da Nóbrega, ACL (corresponding author), Univ Fed Fluminense, Lab Exercise Sci, Dept Physiol & Pharmacol, Rua Prof Hernani Pires de Melo,106,Sala 101, BR-24210130 Niteroi, RJ, Brazil.
EM anobrega@id.uff.br
RI da Nobrega, Antonio/O-5107-2019; Sales, Allan/ABA-8691-2021; Vianna,
   Lauro/A-8188-2008; Silva, Bruno/F-7781-2010; Fernandes, Igor
   Alexandre/G-9589-2012; Rocha, Natalia Galito/AAN-7903-2020
OI Vianna, Lauro/0000-0002-5747-0295; Silva, Bruno/0000-0003-0473-3706;
   Fernandes, Igor Alexandre/0000-0003-3873-2656; Fernandes, Igor
   Alexandre/0000-0002-0206-6316; Rocha, Natalia Galito/0000-0002-1990-9834
FU Coordination for the Improvement of Higher Education Personnel (CAPES);
   Brazilian National Council for Scientific and Technological Development
   - CNPq; Foundation for Research Support of the State of Rio de Janeiro
   (FAPERJ); Brazilian Financing Agency of Studies and Projects (FINEP)
FX This study was supported by the Coordination for the Improvement of
   Higher Education Personnel (CAPES), Brazilian National Council for
   Scientific and Technological Development - CNPq, Foundation for Research
   Support of the State of Rio de Janeiro (FAPERJ) and the Brazilian
   Financing Agency of Studies and Projects (FINEP).
CR Aizawa K, 2009, DIABETES VASC DIS RE, V6, P181, DOI 10.1177/1479164109336375
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Atkinson G, 2013, ATHEROSCLEROSIS, V226, P425, DOI 10.1016/j.atherosclerosis.2012.11.027
   Atkinson G, 2013, J HYPERTENS, V31, P287, DOI 10.1097/HJH.0b013e32835b8164
   Balligand JL, 2009, PHYSIOL REV, V89, P481, DOI 10.1152/physrev.00042.2007
   Berry KL, 2000, CLIN SCI, V99, P261, DOI 10.1042/CS20000028
   Black MA, 2008, HYPERTENSION, V51, P203, DOI 10.1161/HYPERTENSIONAHA.107.101014
   Black MA, 2009, AM J PHYSIOL-HEART C, V297, pH1109, DOI 10.1152/ajpheart.00226.2009
   Carson RT, 1999, J IMMUNOL METHODS, V227, P41, DOI 10.1016/S0022-1759(99)00069-1
   Hamed SA, 2010, J STROKE CEREBROVASC, V19, P92, DOI 10.1016/j.jstrokecerebrovasdis.2009.04.007
   Higashi Y, 2009, CIRC J, V73, P411, DOI 10.1253/circj.CJ-08-1102
   Irace C, 2008, ATHEROSCLEROSIS, V200, P439, DOI 10.1016/j.atherosclerosis.2007.12.036
   Kizhakekuttu TJ, 2010, J APPL PHYSIOL, V109, P959, DOI 10.1152/japplphysiol.00532.2010
   Lind L, 2008, ATHEROSCLEROSIS, V196, P795, DOI 10.1016/j.atherosclerosis.2007.01.014
   Liuni A, 2010, AM J PHYSIOL-HEART C, V299, pH939, DOI 10.1152/ajpheart.00271.2010
   McNeill AM, 2005, DIABETES CARE, V28, P385, DOI 10.2337/diacare.28.2.385
   Padilla J, 2009, J VASC RES, V46, P592, DOI 10.1159/000226227
   Parker BA, 2011, AM J PHYSIOL-HEART C, V301, pH1118, DOI 10.1152/ajpheart.00400.2011
   Pyke KE, 2007, J APPL PHYSIOL, V102, P1510, DOI 10.1152/japplphysiol.01024.2006
   Skogstrand K, 2005, CLIN CHEM, V51, P1854, DOI 10.1373/clinchem.2005.052241
   Suzuki T, 2008, AM HEART J, V156, P405, DOI 10.1016/j.ahj.2008.02.022
   Thijssen DHJ, 2008, AM J PHYSIOL-HEART C, V295, pH1927, DOI 10.1152/ajpheart.00405.2008
   Thijssen DHJ, 2011, AM J PHYSIOL-HEART C, V300, pH2, DOI 10.1152/ajpheart.00471.2010
   Title LM, 2008, VASC MED, V13, P263, DOI 10.1177/1358863X08095154
   Yeboah J, 2007, CIRCULATION, V115, P2390, DOI 10.1161/CIRCULATIONAHA.106.678276
   Yeboah J, 2009, CIRCULATION, V120, P502, DOI 10.1161/CIRCULATIONAHA.109.864801
   Zhang CH, 2008, BASIC RES CARDIOL, V103, P398, DOI 10.1007/s00395-008-0733-0
NR 27
TC 25
Z9 28
U1 0
U2 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1475-0961
EI 1475-097X
J9 CLIN PHYSIOL FUNCT I
JI Clin. Physiol. Funct. Imaging
PD JUL
PY 2014
VL 34
IS 4
BP 270
EP 276
DI 10.1111/cpf.12092
PG 7
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA AN4PH
UT WOS:000340569600004
PM 24119214
DA 2025-06-11
ER

PT J
AU Schumacher, L
   Abbott, LC
AF Schumacher, Lauren
   Abbott, Louise C.
TI Effects of methyl mercury exposure on pancreatic beta cell development
   and function
SO JOURNAL OF APPLIED TOXICOLOGY
LA English
DT Review
DE Methyl mercury; pancreas; oxidative stress; pancreatic beta cells; type
   2 diabetes; metabolic syndrome; insulin resistance; antioxidants
ID ENDOPLASMIC-RETICULUM STRESS; PERSISTENT ORGANIC POLLUTANTS; CHRONIC
   OXIDATIVE STRESS; METABOLIC SYNDROME; GLUCOSE TOXICITY; GENE-EXPRESSION;
   HEAVY-METALS; VEGF-A; METHYLMERCURY; CHLORIDE
AB Methyl mercury is an environmental contaminant of worldwide concern. Since the discovery of methyl mercury exposure due to eating contaminated fish as the underlying cause of the Minamata disaster, the scientific community has known about the sensitivity of the developing central nervous system to mercury toxicity. Warnings are given to pregnant women and young children to limit consumption of foods containing methyl mercury to protect the embryonic, fetal and postnatally developing central nervous system. However, evidence also suggests that exposure to methyl mercury or various forms of inorganic mercury may also affect development and function of other organs. Numerous reports indicate a worldwide increase in diabetes, particularly type 2 diabetes. Quite recently, methyl mercury has been shown to have adverse effects on pancreatic beta () cell development and function, resulting in insulin resistance and hyperglycemia and may even lead to the development of diabetes. This review discusses possible mechanisms by which methyl mercury exposure may adversely affect pancreatic cell development and function, and the role that methyl mercury exposure may have in the reported worldwide increase in diabetes, particularly type 2 diabetes. While additional information is needed regarding associations between mercury exposure and specific mechanisms of the pathogenesis of diabetes in the human population, methyl mercury's adverse effects on the body's natural sources of antioxidants suggest that one possible therapeutic strategy could involve supplementation with antioxidants. Thus, it is important that additional investigation be undertaken into the role of methyl mercury exposure and reduced pancreatic cell function. Copyright (c) 2016 John Wiley & Sons, Ltd.
C1 [Schumacher, Lauren; Abbott, Louise C.] Texas A&M Univ, Coll Vet Med, Dept Vet Integrat Biosci, 4458 TAMU, College Stn, TX 77843 USA.
C3 Texas A&M University System; Texas A&M University College Station
RP Abbott, LC (corresponding author), Texas A&M Univ, Coll Vet Med, Dept Vet Integrat Biosci, 4458 TAMU, College Stn, TX 77843 USA.
EM labbott@cvm.tamu.edu
RI Abbott, Louise/AAC-4392-2022
CR Abdelouahab N, 2008, ENVIRON RES, V107, P380, DOI 10.1016/j.envres.2008.01.006
   ALLY A, 1984, TOXICOL APPL PHARM, V76, P207, DOI 10.1016/0041-008X(84)90001-2
   [Anonymous], MERCURY TIME TO ACT
   Aschner M, 2002, MOL PSYCHIATR, V7, pS40, DOI 10.1038/sj.mp.4001176
   Banhegyi G, 2007, ANN NY ACAD SCI, V1113, P58, DOI 10.1196/annals.1391.007
   Basseri S, 2012, BIOCHEM RES INT, V2012, DOI 10.1155/2012/841362
   Baynes JW, 1999, DIABETES, V48, P1, DOI 10.2337/diabetes.48.1.1
   BLOOM GD, 1972, BIOCHEM J, V129, P241, DOI 10.1042/bj1290241
   Bourdineaud JP, 2011, ENVIRON INT, V37, P303, DOI 10.1016/j.envint.2010.09.003
   Caito SW, 2015, ANTIOXID REDOX SIGN, V23, P578, DOI 10.1089/ars.2015.6289
   Carpenter David O., 2011, Reviews on Environmental Health, V26, P61, DOI 10.1515/REVEH.2011.009
   Carranza-Rosales P, 2005, TOXICOLOGY, V210, P111, DOI 10.1016/j.tox.2005.01.006
   Carratu MR, 2015, OPEN ACC TOXICOL, V1, P1
   Castoldi AF, 2008, REGUL TOXICOL PHARM, V51, P215, DOI 10.1016/j.yrtph.2008.03.005
   Chang JW, 2011, J HAZARD MATER, V185, P749, DOI 10.1016/j.jhazmat.2010.09.084
   Chen CY, 2006, SCI TOTAL ENVIRON, V366, P627, DOI 10.1016/j.scitotenv.2005.12.021
   Chen CY, 2006, ENVIRON HEALTH PERSP, V114, P297, DOI 10.1289/ehp.7861
   Chen W, 2009, ENDOCRINOLOGY, V150, P570, DOI 10.1210/en.2008-1009
   Chen YW, 2006, CHEM RES TOXICOL, V19, P1080, DOI 10.1021/tx0600705
   Chen YW, 2006, DIABETES, V55, P1614, DOI 10.2337/db06-0029
   Chen YW, 2009, ISLETS, V1, P169, DOI 10.4161/isl.1.3.9262
   Chen YW, 2010, TOXICOL APPL PHARM, V243, P323, DOI 10.1016/j.taap.2009.11.024
   Cho JH, 2011, J DIABETES INVEST, V2, P6, DOI 10.1111/j.2040-1124.2010.00072.x
   Choi SM, 2004, J TOXICOL ENV HEAL B, V7, P1, DOI 10.1080/10937400490253229
   Cnop M, 2005, DIABETES, V54, pS97, DOI 10.2337/diabetes.54.suppl_2.S97
   Cnop M, 2012, TRENDS MOL MED, V18, P59, DOI 10.1016/j.molmed.2011.07.010
   Courcoulas AP, 2014, JAMA SURG, V149, P1323, DOI 10.1001/jamasurg.2014.2440
   Crespo-López ME, 2009, PHARMACOL RES, V60, P212, DOI 10.1016/j.phrs.2009.02.011
   De Leu N, 2014, DIABETOLOGIA, V57, P140, DOI 10.1007/s00125-013-3076-9
   DeRosa C, 1998, J TOXICOL ENV HEAL B, V1, P3, DOI 10.1080/10937409809524541
   Drevnick PE, 2007, ENVIRON SCI TECHNOL, V41, P7266, DOI 10.1021/es0712322
   Ellingsen DG, 2000, J APPL TOXICOL, V20, P483, DOI 10.1002/1099-1263(200011/12)20:6<483::AID-JAT722>3.0.CO;2-I
   Eom SY, 2014, INT ARCH OCC ENV HEA, V87, P501, DOI 10.1007/s00420-013-0891-8
   Farina M, 2011, LIFE SCI, V89, P555, DOI 10.1016/j.lfs.2011.05.019
   Favre D, 2011, DIABETOLOGIA, V54, P2337, DOI 10.1007/s00125-011-2165-x
   Fujimura M, 2009, NEUROTOXICOLOGY, V30, P1000, DOI 10.1016/j.neuro.2009.08.001
   Futatsuka M, 1996, J Epidemiol, V6, P204
   Gassó S, 2001, J NEUROSCI RES, V66, P135, DOI 10.1002/jnr.1205
   GILMOUR CC, 1991, ENVIRON POLLUT, V71, P131, DOI 10.1016/0269-7491(91)90031-Q
   Gleason CE, 2000, AM J PHYSIOL-ENDOC M, V279, pE997, DOI 10.1152/ajpendo.2000.279.5.E997
   Gochfeld M, 2003, ECOTOX ENVIRON SAFE, V56, P174, DOI 10.1016/S0147-6513(03)00060-5
   Goering PL, 1999, TOXICOL LETT, V105, P183, DOI 10.1016/S0378-4274(99)00002-8
   Gray J.E., 2003, Geologic studies of mercury by the US Geological Survey
   Grotto D, 2009, ARCH TOXICOL, V83, P249, DOI 10.1007/s00204-008-0353-3
   HARE MF, 1995, J PHARMACOL EXP THER, V272, P1016
   Harmon JS, 2005, J BIOL CHEM, V280, P11107, DOI 10.1074/jbc.M410345200
   He K, 2013, DIABETES CARE, V36, P1584, DOI 10.2337/dc12-1842
   He X, 2013, HYPERTENSION, V62, pA479
   Hirooka T, 2013, J TOXICOL SCI, V38, P837
   Hsi HC, 2014, CHEMOSPHERE, V100, P71, DOI 10.1016/j.chemosphere.2013.12.068
   Jeppesen C, 2015, ENVIRON RES, V143, P192, DOI 10.1016/j.envres.2015.10.013
   Johnson JD, 2010, ADV EXP MED BIOL, V654, P447, DOI 10.1007/978-90-481-3271-3_19
   Kaneto H, 1999, DIABETES, V48, P2398, DOI 10.2337/diabetes.48.12.2398
   Kaneto H, 2005, INT J BIOCHEM CELL B, V37, P1595, DOI 10.1016/j.biocel.2005.04.003
   Kaneto Hideaki, 2005, Am J Ther, V12, P529, DOI 10.1097/01.mjt.0000178773.31525.c2
   Kawasaki E, 2004, DIABETES RES CLIN PR, V66, pS27, DOI 10.1016/j.diabres.2003.09.015
   KUBISCH HM, 1994, P NATL ACAD SCI USA, V91, P9956, DOI 10.1073/pnas.91.21.9956
   Kuo CC, 2013, CURR DIABETES REP, V13, P831, DOI 10.1007/s11892-013-0432-6
   Lammert E, 2001, SCIENCE, V294, P564, DOI 10.1126/science.1064344
   Lee BK, 2013, AM J IND MED, V56, P682, DOI 10.1002/ajim.22107
   Leino O, 2013, FOOD CHEM TOXICOL, V54, P50, DOI 10.1016/j.fct.2011.06.052
   Lenzen S, 2008, BIOCHEM SOC T, V36, P343, DOI 10.1042/BST0360343
   Lind PM, 2013, ENVIRON INT, V55, P1, DOI 10.1016/j.envint.2013.01.017
   Liu H, 2010, EYE, V24, P137, DOI 10.1038/eye.2009.20
   Liu W, 2014, FREE RADICAL RES, V48, P849, DOI 10.3109/10715762.2014.916039
   Lu TH, 2011, TOXICOL LETT, V204, P71, DOI 10.1016/j.toxlet.2011.04.013
   Lui KO, 2014, CURR STEM CELL RES T, V9, P396, DOI 10.2174/1574888X09666140710100603
   Mahboob M, 2001, J ENVIRON SCI HEAL B, V36, P687, DOI 10.1081/PFC-100106195
   Moon SS, 2014, ENDOCRINE, V46, P263, DOI 10.1007/s12020-013-0061-5
   MURTI R, 1984, ECOTOX ENVIRON SAFE, V8, P284, DOI 10.1016/0147-6513(84)90032-0
   Myers GJ, 2009, NEUROTOXICOLOGY, V30, P338, DOI 10.1016/j.neuro.2009.01.005
   NAKAGAWA R, 1995, CHEMOSPHERE, V30, P135, DOI 10.1016/0045-6535(94)00383-6
   Newsholme P, 2007, J PHYSIOL-LONDON, V583, P9, DOI 10.1113/jphysiol.2007.135871
   Nikolova G, 2003, CELL TISSUE RES, V314, P33, DOI 10.1007/s00441-003-0739-8
   Osto M, 2013, GEN COMP ENDOCR, V182, P48, DOI 10.1016/j.ygcen.2012.11.019
   Pal S, 2013, DIABETES METAB, V39, P497, DOI 10.1016/j.diabet.2013.01.006
   Park SB, 2009, BIOL TRACE ELEM RES, V130, P218, DOI 10.1007/s12011-009-8336-7
   Qian YC, 2003, NEUROCHEM RES, V28, P153, DOI 10.1023/A:1021664632393
   Qu MY, 2013, BRAIN RES, V1540, P92, DOI 10.1016/j.brainres.2013.10.005
   Rains JL, 2011, FREE RADICAL BIO MED, V50, P567, DOI 10.1016/j.freeradbiomed.2010.12.006
   Rand MD, 2009, NEUROTOXICOLOGY, V30, P794, DOI 10.1016/j.neuro.2009.04.006
   Robertson RP, 2007, CELL BIOCHEM BIOPHYS, V48, P139, DOI 10.1007/s12013-007-0026-5
   Robertson RP, 2004, J BIOL CHEM, V279, P42351, DOI 10.1074/jbc.R400019200
   Rolo AP, 2006, TOXICOL APPL PHARM, V212, P167, DOI 10.1016/j.taap.2006.01.003
   Roos DH, 2011, TOXICOL APPL PHARM, V252, P28, DOI 10.1016/j.taap.2011.01.010
   Scoville DW, 2015, DIABETES, V64, P3772, DOI 10.2337/db15-0281
   Selph S, 2015, ANN INTERN MED, V162, P765, DOI 10.7326/M14-2221
   Seymour Philip A, 2014, Rev Diabet Stud, V11, P51, DOI 10.1900/RDS.2014.11.51
   Sharma SK, 2008, BIOCHEM BIOPH RES CO, V372, P341, DOI 10.1016/j.bbrc.2008.05.052
   Shigenaga K, 1976, Kumamoto Med J, V29, P67
   Skalnaya MG, 2007, J TRACE ELEM MED BIO, V21, P59, DOI 10.1016/j.jtemb.2007.09.019
   Skalnaya MG, 2014, BIOL TRACE ELEM RES, V161, P13, DOI 10.1007/s12011-014-0082-9
   SLACK JMW, 1995, DEVELOPMENT, V121, P1569
   Stacchiotti A, 2009, FOOD CHEM TOXICOL, V47, P2834, DOI 10.1016/j.fct.2009.09.003
   Stacchiotti A, 2009, TOXICOLOGY, V264, P215, DOI 10.1016/j.tox.2009.08.014
   STOHS SJ, 1995, FREE RADICAL BIO MED, V18, P321, DOI 10.1016/0891-5849(94)00159-H
   Sweet LI, 2001, J TOXICOL ENV HEAL B, V4, P161, DOI 10.1080/109374001300339809
   TAKAHASHI A, 1994, BRAIN RES BULL, V34, P47, DOI 10.1016/0361-9230(94)90185-6
   Takeuchi T., 1977, Minamata Disease: Methylmercury poisoning in Minamata and Niigata, Japan, P103
   Talavera-Adame Dodanim, 2015, World J Exp Med, V5, P40, DOI 10.5493/wjem.v5.i2.40
   Tarallo V, 2015, INT J BIOCHEM CELL B, V64, P185, DOI 10.1016/j.biocel.2015.04.008
   Thorens B, 2014, DIABETES OBES METAB, V16, P87, DOI 10.1111/dom.12346
   Tinkov AA, 2015, BIOMETALS, V28, P231, DOI 10.1007/s10534-015-9823-2
   Truong J, 2015, TOXICOL IN VITRO, V29, P953, DOI 10.1016/j.tiv.2015.03.016
   Ueno N, 1999, GASTROENTEROLOGY, V117, P1427, DOI 10.1016/S0016-5085(99)70293-3
   Usuki F, 2004, ACTA NEUROPATHOL, V108, P1, DOI 10.1007/s00401-004-0844-0
   Usuki F, 2000, BIOCHEM BIOPH RES CO, V267, P739, DOI 10.1006/bbrc.1999.2026
   Usuki F, 2013, SCI REP-UK, V3, DOI 10.1038/srep02346
   van Wijngaarden E, 2014, ANN EPIDEMIOL, V24, P273, DOI 10.1016/j.annepidem.2014.01.002
   Vanni E, 2010, DIGEST LIVER DIS, V42, P320, DOI 10.1016/j.dld.2010.01.016
   Wathen JB, 2015, CHEMOSPHERE, V122, P52, DOI 10.1016/j.chemosphere.2014.11.005
   Wong CSC, 2006, SCI TOTAL ENVIRON, V368, P649, DOI 10.1016/j.scitotenv.2005.11.024
   Wu JX, 2015, EXP THER MED, V9, P653, DOI 10.3892/etm.2014.2163
   Xie ZG, 2014, CLIN REV ALLERG IMMU, V47, P174, DOI 10.1007/s12016-014-8422-2
   Yamamoto M, 2014, J APPL TOXICOL, V34, P914, DOI 10.1002/jat.2954
   Yang TY, 2015, ENVIRON TOXICOL PHAR, V39, P157, DOI 10.1016/j.etap.2014.11.020
   Yu XZ, 2010, TOXICOL SCI, V114, P356, DOI 10.1093/toxsci/kfq003
NR 117
TC 31
Z9 34
U1 4
U2 41
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0260-437X
EI 1099-1263
J9 J APPL TOXICOL
JI J. Appl. Toxicol.
PD JAN
PY 2017
VL 37
IS 1
BP 4
EP 12
DI 10.1002/jat.3381
PG 9
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA EC7DF
UT WOS:000388295300001
PM 27594070
DA 2025-06-11
ER

PT J
AU Kim, HJ
   Norton, CE
   Zawieja, SD
   Castorena-Gonzalez, JA
   Davis, MJ
AF Kim, Hae Jin
   Norton, Charles E.
   Zawieja, Scott D.
   Castorena-Gonzalez, Jorge A.
   Davis, Michael J.
TI Acute Metabolic Stress Induces Lymphatic Dysfunction Through
   KATP Channel Activation
SO FUNCTION
LA English
DT Article
DE contractile dysfunction; lymph pump; metabolic syndrome; reactive oxygen
   species; action potential; mitochondrial electron transport chain
ID OXYGEN-FREE RADICALS; REACTIVE OXYGEN; CA2+ CHANNEL; POTASSIUM CHANNELS;
   5-HYDROXYDECANOATE; CONTRACTILITY; MITOCHONDRIA; MECHANISMS; HEART; FLOW
AB Lymphatic dysfunction is an underlying component of multiple metabolic diseases, including diabetes, obesity, and metabolic syndrome. We investigated the roles of KATP channels in lymphatic contractile dysfunction in response to acute metabolic stress induced by inhibition of the mitochondrial electron transport chain. Ex vivo popliteal lymphatic vessels from mice were exposed to the electron transport chain inhibitors antimycin A and rotenone, or the oxidative phosphorylation inhibitor/protonophore, CCCP. Each inhibitor led to a significant reduction in the frequency of spontaneous lymphatic contractions and calculated pump flow, without a significant change in contraction amplitude. Contraction frequency was restored by the K-ATP channel inhibitor, glibenclamide. Lymphatic vessels from mice with global Kir6.1 deficiency or expressing a smooth muscle-specific dominant negative Kir6.1 channel were resistant to inhibition. Antimycin A inhibited the spontaneous action potentials generated in lymphatic muscle and this effect was reversed by glibenclamide, confirming the role of KATP channels. Antimycin A, but not rotenone or CCCP, increased dihydrorhodamine fluorescence in lymphatic muscle, indicating ROS production. Pretreatment with tiron or catalase prevented the effect of antimycin A on wild-type lymphatic vessels, consistent with its action being mediated by ROS. Our results support the conclusion that KATP channels in lymphatic muscle can be directly activated by reduced mitochondrial ATP production or ROS generation, consequent to acute metabolic stress, leading to contractile dysfunction through inhibition of the ionic pacemaker controlling spontaneous lymphatic contractions. We propose that a similar activation of K-ATP channels contributes to lymphatic dysfunction in metabolic disease.
C1 [Kim, Hae Jin; Norton, Charles E.; Zawieja, Scott D.; Davis, Michael J.] Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO 65212 USA.
   [Castorena-Gonzalez, Jorge A.] Tulane Univ, Sch Med, Dept Pharmacol, New Orleans, LA 70112 USA.
C3 University of Missouri System; University of Missouri Columbia; Tulane
   University
RP Davis, MJ (corresponding author), Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO 65212 USA.
EM davismj@health.missouri.edu
RI Norton, Charles/ABF-5088-2022
FU National Institutes of Health [R01HL-141107, HL-122578, R01 HL-168568,
   R00 HL-143198]; National Research Foundation of Korea
   [NRF-2020R1A6A3A03037151]
FX This research was supported by the National Institutes of Health grants
   R01HL-141107 and HL-122578 to M.J.D., R01 HL-168568 to J.A.C.-G., and
   R00 HL-143198 to S.D.Z.; H.J.K. was supported in part by the National
   Research Foundation of Korea grant NRF-2020R1A6A3A03037151.
CR Aittoniemi J, 2009, PHILOS T R SOC B, V364, P257, DOI 10.1098/rstb.2008.0142
   Akl TJ, 2011, AM J PHYSIOL-HEART C, V301, pH1828, DOI 10.1152/ajpheart.00538.2011
   Angeli V, 2004, IMMUNITY, V21, P561, DOI 10.1016/j.immuni.2004.09.003
   Baines CP, 2010, ANNU REV PHYSIOL, V72, P61, DOI 10.1146/annurev-physiol-021909-135929
   Bhatti JS, 2017, BBA-MOL BASIS DIS, V1863, P1066, DOI 10.1016/j.bbadis.2016.11.010
   BIAN K, 1994, J VASC RES, V31, P256, DOI 10.1159/000159051
   Blum KS, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094713
   Bohlen HG, 2011, AM J PHYSIOL-HEART C, V301, pH1897, DOI 10.1152/ajpheart.00260.2011
   Brayden JE, 2002, CLIN EXP PHARMACOL P, V29, P312, DOI 10.1046/j.1440-1681.2002.03650.x
   Cao E, 2021, NAT METAB, V3, P1175, DOI 10.1038/s42255-021-00457-w
   Castorena-Gonzalez JA, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.823266
   Castorena-Gonzalez JA, 2018, CIRC RES, V123, P964, DOI 10.1161/CIRCRESAHA.117.312576
   Chen Q, 2003, J BIOL CHEM, V278, P36027, DOI 10.1074/jbc.M304854200
   Chen YX, 2017, MICROCIRCULATION, V24, DOI 10.1111/micc.12364
   Czepielewski RS, 2021, IMMUNITY, V54, P2795, DOI 10.1016/j.immuni.2021.10.003
   D'hahan N, 1999, P NATL ACAD SCI USA, V96, P12162, DOI 10.1073/pnas.96.21.12162
   Davis Michael J, 2023, Zenodo, DOI 10.5281/ZENODO.8286119
   Davis Michael J, 2023, Zenodo, DOI 10.5281/ZENODO.8286107
   Davis MJ, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-42877-6
   Davis MJ, 2023, FUNCTION, V4, DOI 10.1093/function/zqad017
   Davis MJ, 2023, FRONT PHYSIOL, V13, DOI 10.3389/fphys.2022.1098408
   Davis MJ, 2022, AM J PHYSIOL-CELL PH, V323, pC1018, DOI 10.1152/ajpcell.00137.2022
   Davis MJ, 2020, J PHYSIOL-LONDON, V598, P3107, DOI 10.1113/JP279612
   Davis MJ, 2005, MICROCIRCULATION, V12, P361, DOI 10.1080/10739680590934772
   Davis MJ., 2024, J Physiol
   Foster MN, 2016, PHYSIOL REV, V96, P177, DOI 10.1152/physrev.00003.2015
   Gardenier JC, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms14345
   Gasheva OY, 2007, MICROCIRCULATION, V14, P827, DOI 10.1080/10739680701444065
   Gasheva OY, 2006, J PHYSIOL-LONDON, V575, P821, DOI 10.1113/jphysiol.2006.115212
   González-Loyola A, 2021, ADV DRUG DELIVER REV, V169, P63, DOI 10.1016/j.addr.2020.12.005
   Halestrap AP, 2007, BBA-BIOENERGETICS, V1767, P1007, DOI 10.1016/j.bbabio.2007.05.008
   Hancock EJ, 2023, J GEN PHYSIOL, V155, DOI 10.1085/jgp.202313355
   Hanley PJ, 2005, J PHYSIOL-LONDON, V562, P307, DOI 10.1113/jphysiol.2004.073932
   Hanley PJ, 2002, J PHYSIOL-LONDON, V542, P735, DOI 10.1113/jphysiol.2002.023960
   Hu H, 1999, MOL PHARMACOL, V55, P1000, DOI 10.1124/mol.55.6.1000
   Ichinari K, 1996, J MOL CELL CARDIOL, V28, P1867, DOI 10.1006/jmcc.1996.0179
   Kalyanaraman B, 2012, FREE RADICAL BIO MED, V52, P1, DOI 10.1016/j.freeradbiomed.2011.09.030
   Kim HJ, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-41995-5
   Kim HJ, 2021, BRIT J PHARMACOL, V178, P4119, DOI 10.1111/bph.15602
   Lee SY, 2005, J PHARMACOL EXP THER, V312, P61, DOI 10.1124/jpet.104.074369
   Levick JR, 2010, CARDIOVASC RES, V87, P198, DOI 10.1093/cvr/cvq062
   Li NY, 2003, J BIOL CHEM, V278, P8516, DOI 10.1074/jbc.M210432200
   Li XT, 2010, BBA-GEN SUBJECTS, V1800, P385, DOI 10.1016/j.bbagen.2009.11.012
   Liao S, 2011, P NATL ACAD SCI USA, V108, P18784, DOI 10.1073/pnas.1116152108
   Lim HY, 2009, AM J PATHOL, V175, P1328, DOI 10.2353/ajpath.2009.080963
   Machnik A, 2009, NAT MED, V15, P545, DOI 10.1038/nm.1960
   Malester B, 2007, FASEB J, V21, P2162, DOI 10.1096/fj.06-7821com
   Marino A, 2021, FREE RADICAL BIO MED, V166, P238, DOI 10.1016/j.freeradbiomed.2021.02.047
   Mathias R, 2013, AM J PHYSIOL-GASTR L, V304, pG623, DOI 10.1152/ajpgi.00392.2012
   Nagai T, 2011, MICROCIRCULATION, V18, P463, DOI 10.1111/j.1549-8719.2011.00107.x
   Nichols CG, 2006, NATURE, V440, P470, DOI 10.1038/nature04711
   Nitti MD, 2016, J PHYSIOL-LONDON, V594, P7073, DOI 10.1113/JP273061
   Nores GDG, 2016, INT J OBESITY, V40, P1582, DOI 10.1038/ijo.2016.96
   Norton CE, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12071433
   Norton CE, 2020, AM J PHYSIOL-CELL PH, V318, pC627, DOI 10.1152/ajpcell.00342.2019
   Olszewski WL, 2002, ANN NY ACAD SCI, V979, P52, DOI 10.1111/j.1749-6632.2002.tb04867.x
   Paggio A, 2019, NATURE, V572, P609, DOI 10.1038/s41586-019-1498-3
   Quayle JM, 1997, PHYSIOL REV, V77, P1165, DOI 10.1152/physrev.1997.77.4.1165
   Rehal S, 2018, AM J PHYSIOL-GASTR L, V314, pG408, DOI 10.1152/ajpgi.00340.2017
   Rehal S, 2015, PROSTAG OTH LIPID M, V116, P37, DOI 10.1016/j.prostaglandins.2014.11.001
   Rockson S G, 2008, Lymphat Res Biol, V6, P63, DOI 10.1089/lrb.2008.6201
   Rockson SG, 2018, JCI INSIGHT, V3, DOI 10.1172/jci.insight.123775
   Rossitto G, 2020, J AM COLL CARDIOL, V76, P2817, DOI 10.1016/j.jacc.2020.10.022
   Rossitto G, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-17820-2
   SADRAEI H, 1995, BRIT J PHARMACOL, V115, P1447, DOI 10.1111/j.1476-5381.1995.tb16636.x
   Scallan JP, 2016, J PHYSIOL-LONDON, V594, P5749, DOI 10.1113/JP272088
   Scallan JP, 2015, CARDIOVASC RES, V107, P89, DOI 10.1093/cvr/cvv117
   Scallan JP, 2013, J PHYSIOL-LONDON, V591, P2139, DOI 10.1113/jphysiol.2012.250662
   Scallan JP, 2021, Frontiers in Physiology, V12
   Shi Y, 2007, BRIT J PHARMACOL, V152, P1033, DOI 10.1038/sj.bjp.0707439
   Shi Y, 2001, ARTERIOSCL THROM VAS, V21, P739, DOI 10.1161/01.ATV.21.5.739
   Tian W, 2017, SCI TRANSL MED, V9, DOI 10.1126/scitranslmed.aal3920
   Tokube K, 1996, AM J PHYSIOL-HEART C, V271, pH478, DOI 10.1152/ajpheart.1996.271.2.H478
   Zawieja SD, 2019, J GEN PHYSIOL, V151, P532, DOI 10.1085/jgp.201812294
   Zawieja SD, 2018, AM J PHYSIOL-HEART C, V314, pH991, DOI 10.1152/ajpheart.00499.2017
   Zawieja SD, 2016, MICROCIRCULATION, V23, P558, DOI 10.1111/micc.12307
   Zawieja SD, 2012, AM J PHYSIOL-HEART C, V302, pH643, DOI 10.1152/ajpheart.00606.2011
   Zhang F, 2018, SCIENCE, V361, P599, DOI 10.1126/science.aap9331
   Zhang YQ, 2016, BRIT J PHARMACOL, V173, DOI 10.1111/bph.13578
   Zuberek M, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23169076
NR 80
TC 1
Z9 1
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
EI 2633-8823
J9 FUNCTION
JI Function
PD SEP 10
PY 2024
VL 5
IS 5
AR zqae033
DI 10.1093/function/zqae033
PG 16
WC Cell Biology; Physiology
WE Emerging Sources Citation Index (ESCI)
SC Cell Biology; Physiology
GA F4L2H
UT WOS:001309542500007
PM 39075985
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zeid, AAA
   Raafat, IR
   Ahmed, AG
AF Abo Zeid, Abeer A.
   Rowida Raafat, Ibrahim
   Ahmed, Abeer G.
TI Berberine alleviates monosodium glutamate induced postnatal metabolic
   disorders associated vascular endothelial dysfunction in newborn rats:
   possible role of matrix metalloproteinase-1
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Monosodium glutamate; metabolic syndrome; endothelin-1; matrix
   metalloproteinase; vascular disorder; berberine
ID LOW-DENSITY-LIPOPROTEIN; SMOOTH-MUSCLE-CELLS; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; PROTEIN-KINASE; DIET; EXPRESSION; OBESITY;
   ANTIOXIDANT; MODULATION
AB Excessive food additives Monosodium glutamate (MSG) results in metabolic disorders with increased Cardiovascular diseases CVD. We aimed to emphasise berberine (BBR) effect on MSG induced metabolic syndrome (MetS) and its associated endothelial dysfunction. Newborn rats were divided into control group, MSG group (4 mg/g) each other day for the first 14 days of life and MSG + BBR group that was given MSG then BBR in dose 150 mg/kg/day for 6 weeks. Body weight, food intake, systolic blood pressure, biochemical metabolic and oxidative stress markers were evaluated. Aortic tissue homogenate Endothelin -1 (ET-1) and matrix metalloproteinase -1 (MMP-1) assessment, in addition to histological and EM examination were done. Newborn rats MSG exposure results in typical adult life MetS and oxidative stress with significant increase in ET-1 and MMP-1with aortic vasculopathy. BBR significantly improved all the disturbed parameters; suppress increased body weight (BW), food intake (FI) and partly improved the aortic vasculopathy lesions, holding a promise for BBR as a defending agent against MSG metabolic and vascular disorders.HIGH LIGHT MSG MSG is frequently consumed as a flavour enhancer especially between children and adolescent Excessive utilisation MSG is associated MS with vascular endothelial dysfunction MMP-1 may be involved in atherosclerotic plaque formation BBR has beneficial outcome for metabolic disorders induced by MSG among newly born rats BBR has a role in management vascular inflammation and remodelling
C1 [Abo Zeid, Abeer A.] Tanta Univ, Dept Physiol, Fac Med, Tanta, Egypt.
   [Rowida Raafat, Ibrahim] Tanta Univ, Fac Med, Dept Med Biochem & Mol Biol, El Geesh St, Tanta 31511, Egypt.
   [Ahmed, Abeer G.] Alexandria Univ, Fac Med, Dept Anat, Alexandria, Egypt.
C3 Egyptian Knowledge Bank (EKB); Tanta University; Egyptian Knowledge Bank
   (EKB); Tanta University; Egyptian Knowledge Bank (EKB); Alexandria
   University
RP Raafat, IR (corresponding author), Tanta Univ, Fac Med, Dept Med Biochem & Mol Biol, El Geesh St, Tanta 31511, Egypt.
EM rowaida.yousef@med.tanta.edu.eg
RI Ibrahim, Rowida/AAD-4234-2021
OI Raafat, Rowida/0000-0002-6500-8156
CR Amin M, 2016, FRONT BIOSCI-LANDMRK, V21, P89, DOI 10.2741/4378
   [Anonymous], 2012, EURASIP J ADV SIGNAL, DOI DOI 10.1002/0471704091
   Boden G, 2008, DIABETES, V57, P476, DOI 10.2337/db07-1261
   Böhm F, 2007, CARDIOVASC RES, V76, P8, DOI 10.1016/j.cardiores.2007.06.004
   Butoi E, 2016, BBA-MOL CELL RES, V1863, P1568, DOI 10.1016/j.bbamcr.2016.04.001
   Cao SJ, 2019, J CELL BIOCHEM, V120, P1340, DOI 10.1002/jcb.27102
   Castrogiovanni D, 2008, NEUROENDOCRINOLOGY, V88, P227, DOI 10.1159/000124131
   Chang WG, 2015, BIOCHEM CELL BIOL, V93, P479, DOI 10.1139/bcb-2014-0107
   Chang WG, 2013, METABOLISM, V62, P1159, DOI 10.1016/j.metabol.2013.02.007
   Chatuphonprasert W, 2014, PHARM BIOL, V52, P419, DOI 10.3109/13880209.2013.839714
   Chi LY, 2014, INT J MOL MED, V34, P283, DOI 10.3892/ijmm.2014.1748
   Collison KS, 2009, J LIPID RES, V50, P1521, DOI 10.1194/jlr.M800418-JLR200
   Dalleau S, 2013, CELL DEATH DIFFER, V20, P1615, DOI 10.1038/cdd.2013.138
   Dobiásová M, 2004, CLIN CHEM, V50, P1113, DOI 10.1373/clinchem.2004.033175
   Dong SF, 2015, NAT PROD COMMUN, V10, P895
   El Agamy DF, 2019, BMC UROL, V19, DOI 10.1186/s12894-019-0534-9
   Fatehi-Hassanabad Z, 2005, PHYTOTHER RES, V19, P222, DOI 10.1002/ptr.1661
   Feng XJ, 2019, THERANOSTICS, V9, P1923, DOI 10.7150/thno.30787
   Fussenegger D, 2008, OBES REV, V9, P76, DOI 10.1111/j.1467-789X.2007.00405.x
   Gobatto C. A., 2002, Research Communications in Molecular Pathology and Pharmacology, V111, P89
   Grove KL, 2005, PHYSIOL BEHAV, V86, P646, DOI 10.1016/j.physbeh.2005.08.063
   He K, 2011, AM J CLIN NUTR, V93, P1328, DOI 10.3945/ajcn.110.008870
   Hermanussen M, 2006, EUR J CLIN NUTR, V60, P25, DOI 10.1038/sj.ejcn.1602263
   Hernández-Bautista RJ, 2014, INT J MOL SCI, V15, P11473, DOI 10.3390/ijms150711473
   Horne BD, 2007, AM HEART J, V154, P751, DOI 10.1016/j.ahj.2007.06.030
   Hsieh YS, 2007, J AGR FOOD CHEM, V55, P10437, DOI 10.1021/jf071868c
   Hu XF, 2018, AM J TRANSL RES, V10, P3322
   Huang HL, 2013, BMC MED GENET, V14, DOI 10.1186/1471-2350-14-30
   Huang ZQ, 2013, MOL MED REP, V7, P461, DOI 10.3892/mmr.2012.1236
   Jablonska E, 2007, ADV MED SCI-POLAND, V52, P154
   Kang YE, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0154003
   Kephart WC, 2017, NUTRIENTS, V9, DOI 10.3390/nu9091019
   Kong WJ, 2009, METABOLISM, V58, P109, DOI 10.1016/j.metabol.2008.08.013
   Koracevic D, 2001, J CLIN PATHOL, V54, P356, DOI 10.1136/jcp.54.5.356
   Lam CKL, 2011, DIABETES, V60, P107, DOI 10.2337/db10-0994
   Leung JWC, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026994
   Li L, 2005, DIABETES, V54, P2227, DOI 10.2337/diabetes.54.7.2227
   Li Z, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/289264
   Liu SJ, 2014, BMB REP, V47, P388, DOI 10.5483/BMBRep.2014.47.7.186
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   Ma L, 2015, EUR J PHARMACOL, V755, P102, DOI 10.1016/j.ejphar.2015.02.039
   Ma XA, 2010, METABOLISM, V59, P1619, DOI 10.1016/j.metabol.2010.03.009
   Macarie RD, 2018, J CELL MOL MED, V22, P4366, DOI 10.1111/jcmm.13728
   Magenta A, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/193095
   Maquoi E, 2002, DIABETES, V51, P1093, DOI 10.2337/diabetes.51.4.1093
   Matthews D.R., 1985, DIAETOLOGIA, V28, P214
   Miksztowicz V, 2014, NUTR METAB CARDIOVAS, V24, P294, DOI 10.1016/j.numecd.2013.08.007
   Moeen SS., 2018, Int J Adv Res Bio Sci, V5, P118, DOI [10.22192/ijarbs.2018.05.06.011, DOI 10.22192/IJARBS.2018.05.06.011]
   Munshi RP, 2014, INDIAN J PHARMACOL, V46, P270, DOI 10.4103/0253-7613.132156
   Nègre-Salvayre A, 2017, FREE RADICAL BIO MED, V111, P127, DOI 10.1016/j.freeradbiomed.2016.12.038
   Nho YK, 2008, CLIN CHIM ACTA, V396, P14, DOI 10.1016/j.cca.2008.06.012
   Padilla J, 2018, AM J PHYSIOL-HEART C, V314, pH52, DOI 10.1152/ajpheart.00478.2017
   Park Jonghoon, 2014, J Exerc Nutrition Biochem, V18, P133, DOI 10.5717/jenb.2014.18.2.133
   Pelantová H, 2016, ANAL BIOANAL CHEM, V408, P567, DOI 10.1007/s00216-015-9133-0
   Rathi B, 2013, ANC SCI LIFE, V32, P234, DOI 10.4103/0257-7941.131981
   Srivastava S, 2015, EXCLI J, V14, P247, DOI 10.17179/excli2014-399
   Sun HL, 2016, OBESITY FACTS, V9, P365, DOI 10.1159/000449507
   Titford M, 2009, J HISTOTECHNOL, V32, P9
   Walker R, 2000, J NUTR, V130, p1049S, DOI 10.1093/jn/130.4.1049S
   Wang LX, 2018, EXP THER MED, V15, P1225, DOI 10.3892/etm.2017.5575
   Xu JH, 2017, MOL MED REP, V15, P2765, DOI 10.3892/mmr.2017.6321
   Zhang M, 2013, NEURAL PLAST, V2013, DOI 10.1155/2013/424651
   Zhang Xiao-Dan, 2008, Zhongguo Zhong Yao Za Zhi, V33, P818
   Zhang Y, 2016, ACTA PHARMACOL SIN, V37, P463, DOI 10.1038/aps.2015.147
   Zhu QW, 2016, EXP THER MED, V11, P978, DOI 10.3892/etm.2016.3018
NR 65
TC 5
Z9 5
U1 0
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD MAY 4
PY 2022
VL 128
IS 3
BP 818
EP 829
DI 10.1080/13813455.2020.1729815
EA FEB 2020
PG 12
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA 1U8AJ
UT WOS:000514890600001
PM 32072839
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Shukla, P
   Mukherjee, S
AF Shukla, Pallavi
   Mukherjee, Srabani
TI Mitochondrial dysfunction: An emerging link in the pathophysiology of
   polycystic ovary syndrome
SO MITOCHONDRION
LA English
DT Review
DE Polycystic Ovary syndrome; Mitochondrion; Mitochondrial dysfunction;
   Oxidative stress; Subfertility
ID ENDOPLASMIC-RETICULUM STRESS; NUCLEAR RESPIRATORY FACTORS; TRANSFER-RNA
   GENES; DNA COPY NUMBER; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   SKELETAL-MUSCLE; METABOLIC SYNDROME; MOUSE MODEL; ESSENTIAL-HYPERTENSION
AB Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by irregular menstrual cycles, hyperandrogenism and subfertility. Due to its complex manifestation, the pathogenic mechanism of PCOS is not well defined. Cumulative effect of altered genetic and epigenetic factors along with environmental factors may play a role in the manifestation of PCOS leading to systemic malfunction. With failure of genome-wide association study (GWAS) and other studies performed on nuclear genome to provide any clue for precise mechanism of PCOS pathogenesis, attention has been diverted to mitochondria. Mitochondrion plays an important role in cellular metabolic functions and is linked to Insulin Resistance (IR). Recently, increasing reports suggest that mitochondrial dysfunction may be a contributing factor in the pathogenesis of PCOS. Hence, in this review, we have discussed mitochondrial biology in brief and emphasizes on genetic and epigenetic aspects of mitochondrial dysfunction studied in PCOS women and PCOS-like animal models. We also highlight underlying mechanism behind mitochondrial dysfunction contributing to PCOS and its related complications such as obesity, diabetes, cardiovascular diseases, metabolic syndrome, non-alcoholic fatty liver disease (NAFLD) and cancer. Furthermore, contrasting remarks against involvement of mitochondrial dysfunction in PCOS pathophysiology have also been presented. This review enhances our understanding in relation to mitochondrial dysfunction in the etiology of PCOS and stimulates further research to explore a clear link between mitochondrial dysfunction and PCOS pathogenesis and progression. Understanding pathogenic mechanisms underlying PCOS will open new windows to develop promising therapeutic strategies against PCOS.
C1 [Shukla, Pallavi; Mukherjee, Srabani] ICMR Natl Inst Res Reprod Hlth NIRRH, Dept Mol Endocrinol, Mumbai, Maharashtra, India.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute for
   Research in Reproductive & Child Health (NIRRCH)
RP Shukla, P (corresponding author), ICMR Natl Inst Res Reprod Hlth NIRRH, Dept Mol Endocrinol, Mumbai, Maharashtra, India.
EM shuklap@nirrh.res.in
RI Mukherjee, Srabani/AGZ-9170-2022
OI Shukla, Pallavi/0000-0001-7979-6651
FU National Institute for Research in Reproductive Health and Indian
   Council of Medical Research (ICMR) [REV/797/09-2019]
FX The authors acknowledge the National Institute for Research in
   Reproductive Health and Indian Council of Medical Research (ICMR) for
   providing necessary support (REV/797/09-2019).
CR Achard CS, 2012, ENDOCRINOLOGY, V153, P2164, DOI 10.1210/en.2011-1881
   Ashrafian H, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1001000
   Azhary JMK, 2019, ENDOCRINOLOGY, V160, P119, DOI 10.1210/en.2018-00675
   Bandyopadhyay GK, 2006, DIABETES, V55, P2277, DOI 10.2337/db06-0062
   Bañuls C, 2017, METABOLISM, V71, P153, DOI 10.1016/j.metabol.2017.02.012
   Beckman JS, 1996, AM J PHYSIOL-CELL PH, V271, pC1424
   Bernard-Marissal N, 2018, CELL DEATH DIS, V9, DOI 10.1038/s41419-017-0125-1
   Bohnsack MT, 2018, CELL MOL LIFE SCI, V75, P241, DOI 10.1007/s00018-017-2598-6
   Brenjian S, 2020, AM J REPROD IMMUNOL, V83, DOI 10.1111/aji.13186
   Bruce CR, 2012, DIABETES, V61, P3148, DOI 10.2337/db12-0029
   Chen CC, 2012, J BIOL CHEM, V287, P33116, DOI 10.1074/jbc.C112.406975
   Chen H, 2012, RESTOR NEUROL NEUROS, V30, P237, DOI 10.3233/RNN-2012-110223
   Chinnery PF, 2013, BRIT MED BULL, V106, P135, DOI 10.1093/bmb/ldt017
   Cook KL, 2016, CANCER RES, V76, P5657, DOI 10.1158/0008-5472.CAN-15-2616
   Coppieters N, 2014, NEUROBIOL AGING, V35, P1334, DOI 10.1016/j.neurobiolaging.2013.11.031
   Craven L, 2017, ANNU REV GENOM HUM G, V18, P257, DOI 10.1146/annurev-genom-091416-035426
   Cree-Green M, 2017, J ENDOCR SOC, V1, P931, DOI 10.1210/js.2017-00192
   D'Onofrio N, 2018, ANTIOXID REDOX SIGN, V28, P711, DOI 10.1089/ars.2017.7178
   de Brito OM, 2008, NATURE, V456, P605, DOI 10.1038/nature07534
   Deniaud A, 2008, ONCOGENE, V27, P285, DOI 10.1038/sj.onc.1210638
   Diao FY, 2004, J MOL ENDOCRINOL, V33, P59, DOI 10.1677/jme.0.0330059
   Ding Y, 2018, GENE, V642, P299, DOI 10.1016/j.gene.2017.11.049
   Ding Y, 2017, AM J TRANSL RES, V9, P2984
   Ding Y, 2016, INT J CLIN EXP MED, V9, P4873
   Ding Y, 2016, MOL MED REP, V13, P3169, DOI 10.3892/mmr.2016.4916
   Ding Y, 2016, REPROD SCI, V23, P228, DOI 10.1177/1933719115602777
   Dorn GW, 2015, GENE DEV, V29, P1981, DOI 10.1101/gad.269894.115
   Dorn GW, 2013, BBA-MOL CELL RES, V1833, P233, DOI 10.1016/j.bbamcr.2012.03.008
   Dufour CR, 2007, CELL METAB, V5, P345, DOI 10.1016/j.cmet.2007.03.007
   Dumesic DA, 2016, J CLIN ENDOCR METAB, V101, P4178, DOI 10.1210/jc.2016-2586
   Elgass K, 2013, BBA-MOL CELL RES, V1833, P150, DOI 10.1016/j.bbamcr.2012.05.002
   Eriksen MB, 2011, J CLIN ENDOCR METAB, V96, pE1298, DOI 10.1210/jc.2011-0278
   Feno S, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/9324018
   Díaz-Villanueva JF, 2015, INT J MOL SCI, V16, P17193, DOI 10.3390/ijms160817193
   Filali M, 2009, Reprod Biomed Online, V19 Suppl 4, P4309
   Ghaffarzad A, 2016, INT J FERTIL STERIL, V10, P29
   Giacomello M, 2016, CELL DEATH DIFFER, V23, P1417, DOI 10.1038/cdd.2016.52
   Giorgi C, 2009, INT J BIOCHEM CELL B, V41, P1817, DOI 10.1016/j.biocel.2009.04.010
   Gleyzer N, 2005, MOL CELL BIOL, V25, P1354, DOI 10.1128/MCB.25.4.1354-1366.2005
   Glintborg D, 2016, DAN MED J, V63
   Groenendyk J, 2005, ACTA BIOCHIM POL, V52, P381
   Guzel E, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18040792
   Hager L, 2012, J BIOL CHEM, V287, P20755, DOI 10.1074/jbc.M112.340919
   HOLTE J, 1994, CLIN ENDOCRINOL, V41, P463, DOI 10.1111/j.1365-2265.1994.tb02577.x
   Hsueh WA, 2004, HYPERTENSION, V43, P297, DOI 10.1161/01.HYP.0000113626.76571.5b
   Huss JM, 2004, CIRC RES, V95, P568, DOI 10.1161/01.RES.0000141774.29937.e3
   Hussain T, 2012, INT J MOL CELL MED, V1, P75
   Hutchison SK, 2012, DIABETOLOGIA, V55, P1424, DOI 10.1007/s00125-011-2442-8
   Infantino V, 2011, MOL GENET METAB, V102, P378, DOI 10.1016/j.ymgme.2010.11.166
   Jansen E, 2004, MOL ENDOCRINOL, V18, P3050, DOI 10.1210/me.2004-0074
   Jia LF, 2016, SCI REP-UK, V6, DOI 10.1038/srep19436
   Jornayvaz FR, 2010, ESSAYS BIOCHEM, V47, P69, DOI [10.1042/bse0470069, 10.1042/BSE0470069]
   Kaufman RJ, 2014, BBA-MOL CELL RES, V1843, P2233, DOI 10.1016/j.bbamcr.2014.03.022
   Kim SY, 2016, CURR OPIN CARDIOL, V31, P255, DOI 10.1097/HCO.0000000000000276
   KOCH GLE, 1990, BIOESSAYS, V12, P527, DOI 10.1002/bies.950121105
   Konopka AR, 2015, DIABETES, V64, P2104, DOI 10.2337/db14-1701
   Kusçu NK, 2009, ACTA OBSTET GYN SCAN, V88, P612, DOI 10.1080/00016340902859315
   Lambertini L, 2017, FRONT ENDOCRINOL, V8, DOI 10.3389/fendo.2017.00352
   Lee SH, 2011, METABOLISM, V60, P1677, DOI 10.1016/j.metabol.2011.04.010
   Leonie E, 2012, ENDOCRINOLOGY, V153, P2861, DOI 10.1210/en.2011-1754
   Li W, 2017, J HUAZHONG U SCI-MED, V37, P210, DOI 10.1007/s11596-017-1717-9
   Liu BJ, 2016, SCI REP-UK, V6, DOI 10.1038/srep23421
   Liu Jin, 2012, Sichuan Da Xue Xue Bao Yi Xue Ban, V43, P187
   Liu Q, 2019, TAIWAN J OBSTET GYNE, V58, P447, DOI 10.1016/j.tjog.2019.05.003
   Lu B, 2013, MOL CELL, V49, P121, DOI 10.1016/j.molcel.2012.10.023
   Manev Hari, 2013, Biomol Concepts, V4, P381, DOI 10.1515/bmc-2013-0005
   Mannera S. H. L., 2011, ENDOCRINOLOGY, V152, P332
   Marchi S, 2017, ADV EXP MED BIOL, V997, P49, DOI 10.1007/978-981-10-4567-7_4
   Marshall JC, 2012, FERTIL STERIL, V97, P18, DOI 10.1016/j.fertnstert.2011.11.036
   McLaughlin T, 2011, J CLIN ENDOCR METAB, V96, pE1756, DOI 10.1210/jc.2011-0615
   McMullen PD, 2014, CHEM-BIOL INTERACT, V209, P14, DOI 10.1016/j.cbi.2013.11.006
   Meyers DE, 2013, TEX HEART I J, V40, P385
   Mishra JS, 2018, BIOL REPROD, V98, P520, DOI 10.1093/biolre/ioy017
   Mlinar B, 2011, J STEROID BIOCHEM, V123, P127, DOI 10.1016/j.jsbmb.2010.12.002
   Montgomery MK, 2015, ENDOCR CONNECT, V4, DOI 10.1530/EC-14-0092
   Mposhi A, 2017, FRONT BIOSCI-LANDMRK, V22, P1099, DOI 10.2741/4535
   Muniyappa R, 2013, REV ENDOCR METAB DIS, V14, P5, DOI 10.1007/s11154-012-9229-1
   Navarro A, 2007, AM J PHYSIOL-CELL PH, V292, pC670, DOI 10.1152/ajpcell.00213.2006
   Nita M, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/3164734
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Paixao L, 2017, REPROD BIOL ENDOCRIN, V15, DOI 10.1186/s12958-017-0231-z
   Palmieri VO, 2011, NUTRITION, V27, P773, DOI 10.1016/j.nut.2010.08.016
   Pan JX, 2018, CLIN EPIGENETICS, V10, DOI 10.1186/s13148-018-0442-y
   Piperi C, 2012, J CLIN ENDOCR METAB, V97, P2231, DOI 10.1210/jc.2011-3408
   Rabol R, 2011, EUR J ENDOCRINOL, V165, P631, DOI 10.1530/EJE-11-0419
   Radi R, 2002, BIOL CHEM, V383, P401, DOI 10.1515/BC.2002.044
   Rasmussen KD, 2016, GENE DEV, V30, P733, DOI 10.1101/gad.276568.115
   Rebelo-Guiomar P, 2019, BBA-GENE REGUL MECH, V1862, P429, DOI 10.1016/j.bbagrm.2018.11.005
   Reddy TV, 2019, MITOCHONDRION, V44, P35, DOI 10.1016/j.mito.2017.12.010
   Reddy TV, 2018, GENE, V641, P129, DOI 10.1016/j.gene.2017.10.010
   Rizzo M, 2009, HUM REPROD, V24, P2286, DOI 10.1093/humrep/dep121
   ROBINSON S, 1992, BRIT J OBSTET GYNAEC, V99, P232, DOI 10.1111/j.1471-0528.1992.tb14505.x
   Rosas C, 2016, REPROD SCI, V23, P761, DOI 10.1177/1933719115618283
   Sabuncu T, 2001, CLIN BIOCHEM, V34, P407, DOI 10.1016/S0009-9120(01)00245-4
   Saini SK, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-01743-y
   Samocha-Bonet D, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036320
   Santos JM, 2014, EXP EYE RES, V121, P168, DOI 10.1016/j.exer.2014.02.010
   Satoh JI, 2013, GENE REGUL SYST BIO, V7, P139, DOI 10.4137/GRSB.S13204
   Scarpulla RC, 2012, TRENDS ENDOCRIN MET, V23, P459, DOI 10.1016/j.tem.2012.06.006
   Scarpulla RC, 2008, ANN NY ACAD SCI, V1147, P321, DOI 10.1196/annals.1427.006
   Schmandt RE, 2011, AM J OBSTET GYNECOL, V205, P518, DOI 10.1016/j.ajog.2011.05.042
   Schmitz-Peiffer C, 1999, J BIOL CHEM, V274, P24202, DOI 10.1074/jbc.274.34.24202
   Schon EA, 2012, NAT REV GENET, V13, P878, DOI 10.1038/nrg3275
   Schönthal AH, 2012, SCIENTIFICA, V2012, DOI 10.6064/2012/857516
   Scott I, 2010, ESSAYS BIOCHEM, V47, P85, DOI [10.1042/BSE0470085, 10.1042/bse0470085]
   Seillier M, 2015, EMBO MOL MED, V7, P802, DOI 10.15252/emmm.201404318
   Selen ES, 2015, J PROTEOME RES, V14, P3284, DOI 10.1021/acs.jproteome.5b00307
   Sharma H, 2005, CANCER CELL INT, V5, DOI 10.1186/1475-2867-5-34
   Shen F, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076967
   Shock LS, 2011, P NATL ACAD SCI USA, V108, P3630, DOI 10.1073/pnas.1012311108
   Sirmans SM, 2014, CLIN EPIDEMIOL, V6, P1, DOI 10.2147/CLEP.S37559
   Sisinni L, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20040857
   Skov V, 2007, DIABETES, V56, P2349, DOI 10.2337/db07-0275
   Spritzer PM, 2015, REPRODUCTION, V149, pR219, DOI 10.1530/REP-14-0435
   Stone SJ, 2000, J BIOL CHEM, V275, P34534, DOI 10.1074/jbc.M002865200
   Sugii S, 2011, FEBS LETT, V585, P2121, DOI 10.1016/j.febslet.2011.05.007
   Takahashi N, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-11252-7
   Tan L, 2012, DEVELOPMENT, V139, P1895, DOI 10.1242/dev.070771
   Tang S, 2010, MITOCHONDRION, V10, P350, DOI 10.1016/j.mito.2010.02.003
   Torroni A, 1997, AM J HUM GENET, V60, P1107
   Tripathi YB, 2012, FRONT IMMUNOL, V3, DOI 10.3389/fimmu.2012.00240
   Truban D, 2017, J PARKINSON DIS, V7, P13, DOI 10.3233/JPD-160989
   Tuppen HAL, 2010, BBA-BIOENERGETICS, V1797, P113, DOI 10.1016/j.bbabio.2009.09.005
   Turrens JF, 2003, J PHYSIOL-LONDON, V552, P335, DOI 10.1113/jphysiol.2003.049478
   Uguccioni G, 2010, PPAR RES, V2010, DOI 10.1155/2010/937123
   van der Meer DLM, 2010, NUCLEIC ACIDS RES, V38, P2839, DOI 10.1093/nar/gkq012
   Van Haute L, 2015, J INHERIT METAB DIS, V38, P655, DOI 10.1007/s10545-015-9859-z
   van Tienen FHJ, 2012, J CLIN ENDOCR METAB, V97, P3261, DOI 10.1210/jc.2011-3454
   Venter M, 2017, J AFR, V28, P1
   Ventura-Clapier R, 2008, CARDIOVASC RES, V79, P208, DOI 10.1093/cvr/cvn098
   Victor VM, 2011, J CLIN ENDOCR METAB, V96, P3115, DOI 10.1210/jc.2011-0651
   Victor VM, 2009, J CLIN ENDOCR METAB, V94, P3505, DOI 10.1210/jc.2009-0466
   Wallace DC, 2010, ANNU REV PATHOL-MECH, V5, P297, DOI 10.1146/annurev.pathol.4.110807.092314
   Wang HD, 2015, J STEROID BIOCHEM, V154, P254, DOI 10.1016/j.jsbmb.2015.09.003
   Wang QY, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015479
   Wang T, 2019, INT J BIOL SCI, V15, P714, DOI 10.7150/ijbs.31425
   Wang T, 2015, MOL CELL BIOL, V35, P1281, DOI 10.1128/MCB.01156-14
   Wei YZ, 2008, WORLD J GASTROENTERO, V14, P193, DOI 10.3748/wjg.14.193
   Wild RA, 2011, FERTIL STERIL, V95, P1073, DOI 10.1016/j.fertnstert.2010.12.027
   Wood JR, 2003, J BIOL CHEM, V278, P26380, DOI 10.1074/jbc.M300688200
   Wu LDL, 2012, MOL ENDOCRINOL, V26, P562, DOI 10.1210/me.2011-1362
   Xiao B, 2017, J BIOL CHEM, V292, P16697, DOI 10.1074/jbc.M117.787739
   Xu N, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027286
   Xu WM, 2004, NAT CELL BIOL, V6, P1129, DOI 10.1038/ncb1188
   Zhao HC, 2017, FERTIL STERIL, V107, P467, DOI 10.1016/j.fertnstert.2016.10.039
   Zhao HC, 2015, FREE RADICAL BIO MED, V86, P295, DOI 10.1016/j.freeradbiomed.2015.05.013
   Zhou S, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00748
   Zhou TY, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19020417
   Zhu HY, 2009, CLIN CHIM ACTA, V410, P64, DOI 10.1016/j.cca.2009.09.023
   Zhuo GC, 2012, ARCH GYNECOL OBSTET, V286, P653, DOI 10.1007/s00404-012-2358-7
   Zhuo GC, 2010, BIOCHEM GENET, V48, P157, DOI 10.1007/s10528-009-9308-5
   Zorov DB, 2014, PHYSIOL REV, V94, P909, DOI 10.1152/physrev.00026.2013
   Zuo T, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/8589318
NR 153
TC 51
Z9 56
U1 0
U2 16
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1567-7249
EI 1872-8278
J9 MITOCHONDRION
JI Mitochondrion
PD MAY
PY 2020
VL 52
BP 24
EP 39
DI 10.1016/j.mito.2020.02.006
PG 16
WC Cell Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Genetics & Heredity
GA LJ5UC
UT WOS:000530229300004
PM 32081727
DA 2025-06-11
ER

PT J
AU El-Shinnawi, U
   Soory, M
AF El-Shinnawi, U.
   Soory, M.
TI Actions of Adjunctive Nutritional Antioxidants in Periodontitis and
   Prevalent Systemic Inflammatory Diseases
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Article
DE Chronic inflammatory diseases; mechanisms of action; metabolic syndrome;
   nutritional antioxidants; oxidative stress; periodontitis; therapeutic
   adjuncts
ID VIRGIN OLIVE OIL; IMPROVES ENDOTHELIAL FUNCTION; C-REACTIVE PROTEIN;
   OXIDATIVE STRESS; MEDITERRANEAN DIET; BLOOD-PRESSURE; DOCOSAHEXAENOIC
   ACID; VITAMIN-D; ANTIINFLAMMATORY ACTIVITY; CARDIOVASCULAR-DISEASE
AB Common risk markers for periodontitis and prevalent systemic comorbidities indicate similarities in their progression and molecular mechanisms involved. Resultant pro-oxidant disease profiles provide scope for attenuating their pathogeneses with appropriate adjunctive antioxidants. Levels of oxidative stress markers 8-hydroxy-deoxguanosine (8-HOdG) and malondialdehyde (MDA) are significantly higher in periodontitis and other chronic inflammatory conditions. There is a clear link between periodontitis and diseases associated with significant systemic inflammatory loading, such as metabolic syndrome. Micro-and macro-nutrients have proven to be effective in curbing molecular mechanisms that generate reactive oxygen and nitrogen species. A Mediterranean diet rich in fruits, vegetables, legumes, whole grain, nuts, fish, olive oil and red wine in moderation, could be attributed to the lower occurrence of cardiovascular disease, insulin resistance and other inflammatory diseases in this region. A significant number of naturally occurring flavonoids have been identified in these products. Flavonoids comprising flavonols, flavones and isoflavones are potent free radical scavengers, effective in inhibiting lipid peroxidation, with anti-atherosclerotic and antihypertensive effects. The phenolic compound oleocanthal isolated in virgin olive oil has similar anti-inflammatory actions to that of ibuprofen. The anti-atherogenic effects of MUFA and PUFA in nuts, enhance endothelial function by reducing total cholesterol, oxidized LDL, hs-CRP, sVCAM-1 levels, lipids, lipoproteins and inflammatory markers. Epigenetics influenced by environmental factors and interactions between genes and nutrients, are important considerations in influencing these effects. Using antioxidants as therapeutic adjuncts could enhance the antioxidant capacity of an inherent glutathione system and overcome oxidative effects, thereby mitigating therapeutic side-effects.
C1 [El-Shinnawi, U.] Mansoura Univ, Fac Dent, Periodontol & Oral Med, Mansoura, Egypt.
   [Soory, M.] Kings Coll London, Inst Dent, Periodontol, London SE5 9RW, England.
C3 Egyptian Knowledge Bank (EKB); Mansoura University; University of
   London; King's College London
RP Soory, M (corresponding author), Kings Coll London, Inst Dent, Periodontol, Denmark Hill, London SE5 9RW, England.
EM mena.soory@kcl.ac.uk
CR Alexiadou K, 2011, EUR J INTERN MED, V22, P141, DOI 10.1016/j.ejim.2010.11.008
   Alshouibi EN, 2013, J DENT RES, V92, P689, DOI 10.1177/0022034513495239
   de Menezes AMA, 2012, J PERIODONTOL, V83, P514, DOI 10.1902/jop.2011.110332
   [Anonymous], INT J CIRCUMPOLAR HL
   Arab L, 2009, STROKE, V40, P1786, DOI 10.1161/STROKEAHA.108.538470
   Armutcu F, 2008, CLIN CHEM LAB MED, V46, P785, DOI 10.1515/CCLM.2008.166
   Asher GN, 2012, BMC COMPLEM ALTERN M, V12, DOI 10.1186/1472-6882-12-26
   Baliga MS, 2012, FOOD FUNCT, V3, P1109, DOI 10.1039/c2fo30097d
   Baltacioglu E, 2014, J PERIODONTOL, V85, P1432, DOI 10.1902/jop.2014.130654
   Bassaganya-Riera J, 2010, CURR OPIN CLIN NUTR, V13, P569, DOI 10.1097/MCO.0b013e32833b648e
   Beaudoin MS, 2013, AM J PHYSIOL-REG I, V305, pR542, DOI 10.1152/ajpregu.00200.2013
   Belludi Sphoorthi Anup, 2013, J Contemp Dent Pract, V14, P1054
   Berryman CE, 2013, J NUTR, V143, P788, DOI 10.3945/jn.112.170993
   Bogdanski P, 2012, NUTR RES, V32, P421, DOI 10.1016/j.nutres.2012.05.007
   Brandolini A., 2013, J SCI FOOD AGR
   Buitrago-Lopez A, 2011, BMJ-BRIT MED J, V343, DOI 10.1136/bmj.d4488
   Bulló M, 2011, CURR TOP MED CHEM, V11, P1797, DOI 10.2174/156802611796235062
   Bullon P, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0074234
   Chandra RV, 2012, QUINTESSENCE INT, V43, P401
   Chapple ILC, 2007, J CLIN PERIODONTOL, V34, P103, DOI 10.1111/j.1600-051X.2006.01029.x
   Chapple ILC, 2007, PERIODONTOL 2000, V43, P160, DOI 10.1111/j.1600-0757.2006.00178.x
   Cheng XH, 2013, FREE RADICAL BIO MED, V64, P4, DOI 10.1016/j.freeradbiomed.2013.07.025
   Cicerale S, 2012, CURR OPIN BIOTECH, V23, P129, DOI 10.1016/j.copbio.2011.09.006
   Corega C., 2014, MINERVA STOMATOL
   Dalcico R, 2013, J PERIODONTOL, V84, P1145, DOI 10.1902/jop.2012.120114
   Dar SA, 2013, PHARM BIOL, V51, P170, DOI 10.3109/13880209.2012.715172
   Dreher ML, 2012, NUTR REV, V70, P234, DOI 10.1111/j.1753-4887.2011.00467.x
   Edirisinghe I, 2008, CLIN SCI, V114, P331, DOI 10.1042/CS20070264
   EI-Sharkawy H, 2010, J PERIODONTOL, V81, P1635, DOI 10.1902/jop.2010.090628
   Eilat-Adar S, 2013, NUTRIENTS, V5, P3646, DOI 10.3390/nu5093646
   El-Shinnawi U, 2013, RECENT PATENTS ENDOC, V7, P169, DOI 10.2174/18715303113139990040
   Engelhard YN, 2006, AM HEART J, V151, DOI 10.1016/j.ahj.2005.05.008
   Esen Ç, 2012, J PERIODONTOL, V83, P773, DOI 10.1902/jop.2011.110420
   Estruch R, 2013, NEW ENGL J MED, V368, P1279, DOI 10.1056/NEJMoa1200303
   Mesas AE, 2011, AM J CLIN NUTR, V94, P1113, DOI 10.3945/ajcn.111.016667
   Feghali K, 2012, J AGR FOOD CHEM, V60, P5728, DOI 10.1021/jf203304v
   Figuero E, 2006, STEROIDS, V71, P1062, DOI 10.1016/j.steroids.2006.09.003
   Gans JMD, 2010, ARTERIOSCL THROM VAS, V30, P1665, DOI 10.1161/ATVBAHA.109.201939
   Garcia MN, 2011, J PERIODONTOL, V82, P25, DOI 10.1902/jop.2010.100207
   Gokhale Neeraja H., 2013, Journal of Dietary Supplements, V10, P93, DOI 10.3109/19390211.2013.790332
   Cernadas LG, 2014, NUTR HOSP, V29, P237, DOI 10.3305/nh.2014.29.2.7067
   Grosso G, 2014, CURR PHARM DESIGN, V20, P5039, DOI 10.2174/1381612819666131206112144
   Harland JI, 2012, NUTR RES REV, V25, P249, DOI 10.1017/S0954422412000170
   Harpenau Lisa A, 2011, J Calif Dent Assoc, V39, P309
   Hattersley JG, 2014, J CLIN ENDOCR METAB, V99, pE2599, DOI 10.1210/jc.2014-2302
   Holick M.F., 2012, DERMATOENDOCRINOLOGY, V4, P83
   Hooper L, 2012, AM J CLIN NUTR, V95, P740, DOI 10.3945/ajcn.111.023457
   Houston M, 2014, WORLD J CARDIOL, V6, P38, DOI 10.4330/wjc.v6.i2.38
   Houston MC, 2013, ALTERN THER HEALTH M, V19, P32
   Hur SJ, 2012, NUTR RES, V32, P801, DOI 10.1016/j.nutres.2012.09.013
   Jung HA, 2013, FOOD CHEM TOXICOL, V59, P199, DOI 10.1016/j.fct.2013.05.061
   Kang YM, 2013, ENVIRON TOXICOL PHAR, V35, P395, DOI 10.1016/j.etap.2013.01.009
   Karatzi K, 2012, J CLIN HYPERTENS, V14, P630, DOI 10.1111/j.1751-7176.2012.00649.x
   Katz DL, 2012, J AM COLL NUTR, V31, P415, DOI 10.1080/07315724.2012.10720468
   Kawaguchi K, 2011, CURR TOP MED CHEM, V11, P1767, DOI 10.2174/156802611796235152
   Ksouri R, 2012, CRIT REV BIOTECHNOL, V32, P289, DOI 10.3109/07388551.2011.630647
   Kuzmanova D, 2012, J CLIN PERIODONTOL, V39, P905, DOI 10.1111/j.1600-051X.2012.01927.x
   Larson A, 2012, NUTR RES, V32, P557, DOI 10.1016/j.nutres.2012.06.018
   Liu KN, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039878
   Liu XM, 2004, LIFE SCI, V74, P855, DOI 10.1016/j.lfs.2003.07.037
   Lucas L, 2011, CURR PHARM DESIGN, V17, P754, DOI 10.2174/138161211795428911
   Maranhao PA, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-32
   Marchetti E, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-88
   Martina V, 2008, DIABETES CARE, V31, P940, DOI 10.2337/dc07-2251
   Maruyama T, 2011, ARCH ORAL BIOL, V56, P48, DOI 10.1016/j.archoralbio.2010.08.015
   Masi S, 2011, FREE RADICAL BIO MED, V50, P730, DOI 10.1016/j.freeradbiomed.2010.12.031
   Meisel P, 2014, J PERIODONTOL, V85, pE160, DOI 10.1902/jop.2013.130456
   Miricescu D, 2014, ACTA ODONTOL SCAND, V72, P42, DOI 10.3109/00016357.2013.795659
   Mobasheri A, 2013, ANN NY ACAD SCI, V1290, P59, DOI 10.1111/nyas.12145
   Mouzaoui S, 2012, INT IMMUNOPHARMACOL, V12, P302, DOI 10.1016/j.intimp.2011.10.010
   Muley A, 2012, CURR DIABETES REV, V8, P162, DOI 10.2174/157339912800564016
   Ng N, 2014, J PERIODONTOL, V85, P1042, DOI 10.1902/jop.2013.130179
   Nibali L, 2013, J CLIN ENDOCR METAB, V98, P913, DOI 10.1210/jc.2012-3552
   Niki E, 2014, FREE RADICAL BIO MED, V66, P3, DOI 10.1016/j.freeradbiomed.2013.03.022
   Nishi SK, 2014, NUTR METAB CARDIOVAS, V24, P845, DOI 10.1016/j.numecd.2014.04.001
   Ochiai R, 2009, HYPERTENS RES, V32, P969, DOI 10.1038/hr.2009.132
   Oliver E, 2012, J NUTR BIOCHEM, V23, P1192, DOI 10.1016/j.jnutbio.2011.06.014
   Orem A, 2013, J CLIN LIPIDOL, V7, P123, DOI 10.1016/j.jacl.2012.10.005
   Ozdemir H, 2012, J PERIODONTAL RES, V47, P74, DOI 10.1111/j.1600-0765.2011.01406.x
   Pal S, 2013, OBES REV, V14, P324, DOI 10.1111/obr.12005
   Palatini P, 2009, J HYPERTENS, V27, P1594, DOI 10.1097/HJH.0b013e32832ba850
   Paran E, 2009, CARDIOVASC DRUG THER, V23, P145, DOI 10.1007/s10557-008-6155-2
   Park SY, 2011, INT IMMUNOPHARMACOL, V11, P1907, DOI 10.1016/j.intimp.2011.07.023
   Patki G, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0074522
   Pauwels EKJ, 2010, MED PRIN PRACT, V20, P103, DOI 10.1159/000321197
   Pendyala G, 2013, N AM J MED SCI, V5, P51, DOI 10.4103/1947-2714.106208
   Perk J, 2012, Eur Heart J, V33, P1635
   Pons E, 2014, PLANT BIOTECHNOL J, V12, P17, DOI 10.1111/pbi.12112
   Poulsen MM, 2013, ANN NY ACAD SCI, V1290, P74, DOI 10.1111/nyas.12141
   Raederstorff D, 2013, ANN NY ACAD SCI, V1290, P136, DOI 10.1111/nyas.12147
   Rahman ST, 2012, J CARDIOVASC PHARM T, V17, P139, DOI 10.1177/1074248411413282
   Rahman Z. A., 2006, Endocrine Metabolic & Immune Disorders-Drug Targets, V6, P279, DOI 10.2174/187153006778250037
   Raitakari OT, 2000, FREE RADICAL BIO MED, V28, P1100, DOI 10.1016/S0891-5849(00)00201-X
   Ramyaa P., 2013, BIOCHIM BIOPHYS ACTA, V1840, P681
   Rees K., 2012, COCHRANE DB SYST REV, V8
   Reinhart KM, 2008, ANN PHARMACOTHER, V42, P1766, DOI 10.1345/aph.1L319
   Reuland DJ, 2013, EXERC SPORT SCI REV, V41, P162, DOI 10.1097/JES.0b013e3182948a1e
   Rosenfeldt FL, 2007, J HUM HYPERTENS, V21, P297, DOI 10.1038/sj.jhh.1002138
   Sacchi R, 2014, CANCER TREAT RES, V159, P325, DOI 10.1007/978-3-642-38007-5_19
   Santos FL, 2012, OBES REV, V13, P1048, DOI 10.1111/j.1467-789X.2012.01021.x
   Sapadin AN, 2006, J AM ACAD DERMATOL, V54, P258, DOI 10.1016/j.jaad.2005.10.004
   Sato M, 2002, ANN NUTR METAB, V46, P259, DOI 10.1159/000066495
   Saw C.L., 2013, FOOD CHEM TOXICOL
   Schwartz N, 2012, J AM GERIATR SOC, V60, P676, DOI 10.1111/j.1532-5415.2011.03866.x
   Sezer U, 2013, J PERIODONTOL, V84, P785, DOI 10.1902/jop.2012.120179
   Shai I, 2010, CIRCULATION, V121, P1200, DOI 10.1161/CIRCULATIONAHA.109.879254
   Sharma N., 2012, International Journal of Oral and Maxillofacial Pathology, V3, P21
   Singh-Dang T, 2014, PERIODONTOL 2000, V64, P154, DOI 10.1111/prd.12001
   Sofi F, 2010, AM J CLIN NUTR, V92, P1189, DOI 10.3945/ajcn.2010.29673
   Soory M., 2015, GLUTATHIONE DIETARY, P45
   Soory Mena, 2012, Infectious Disorders - Drug Targets, V12, P301
   Staudte H, 2012, QUINTESSENCE INT, V43, P907
   Stulnig G, 2013, ATHEROSCLEROSIS, V230, P406, DOI 10.1016/j.atherosclerosis.2013.08.002
   Sugiyama S, 2012, J CLIN BIOCHEM NUTR, V51, P108, DOI 10.3164/jcbn.11-103
   Surra JC, 2013, BRIT J NUTR, V109, P202, DOI 10.1017/S000711451200092X
   Tabbaa M, 2013, NUTRIENTS, V5, P3299, DOI 10.3390/nu5083299
   Tamaki N, 2011, CLIN ORAL INVEST, V15, P953, DOI 10.1007/s00784-010-0458-y
   Tilakaratne A., 2014, Infectious Disorders - Drug Targets, V14, P14
   Tilakaratne A, 2014, OPEN DENT J, V8, P109, DOI 10.2174/1874210601408010109
   Tilakaratne A, 2012, RECENT PATENTS ENDOC, V6, P73, DOI 10.2174/187221412799015281
   Tinti F, 2014, REDOX BIOL, V2, P36, DOI 10.1016/j.redox.2013.11.008
   Tinti F, 2012, SCI REP-UK, V2, DOI 10.1038/srep00566
   Torres A, 2012, ARCH LATINOAM NUTR, V62, P381
   Trimarco V, 2012, HIGH BLOOD PRESS CAR, V19, P117, DOI 10.2165/11632160-000000000-00000
   Tsai KL, 2012, J NUTR BIOCHEM, V23, P458, DOI 10.1016/j.jnutbio.2011.01.011
   Urpi-Sarda M, 2012, PHARMACOL RES, V65, P577, DOI 10.1016/j.phrs.2012.03.006
   Van der Velden U, 2011, J CLIN PERIODONTOL, V38, P142, DOI 10.1111/j.1600-051X.2010.01663.x
   Vilskersts R, 2011, PHARMACOL REP, V63, P752, DOI 10.1016/S1734-1140(11)70587-4
   Vinson JA, 2012, FOOD FUNCT, V3, P134, DOI 10.1039/c2fo10152a
   Wang L, 2013, EUR J NUTR, V52, P1771, DOI 10.1007/s00394-012-0480-8
   Wang ZM, 2011, AM J CLIN NUTR, V93, P506, DOI 10.3945/ajcn.110.005363
   Wong RHX, 2013, ANN NY ACAD SCI, V1290, P52, DOI 10.1111/nyas.12155
   Wood N, 2004, J CLIN PERIODONTOL, V31, P574, DOI 10.1111/j.1600-051X.2004.00531.x
   Zibadi S, 2008, NUTR RES, V28, P315, DOI 10.1016/j.nutres.2008.03.003
NR 134
TC 9
Z9 9
U1 1
U2 10
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2015
VL 15
IS 4
BP 261
EP 276
DI 10.2174/1871530315666150429125041
PG 16
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA CY8NW
UT WOS:000366666500002
PM 25922082
DA 2025-06-11
ER

PT J
AU Kong, ASY
   Lai, KS
   Hee, CW
   Loh, JY
   Lim, SHE
   Sathiya, M
AF Kong, Amanda Shen-Yee
   Lai, Kok Song
   Hee, Cheng-Wan
   Loh, Jiun Yan
   Lim, Swee Hua Erin
   Sathiya, Maran
TI Oxidative Stress Parameters as Biomarkers of Cardiovascular Disease
   towards the Development and Progression
SO ANTIOXIDANTS
LA English
DT Review
DE reactive oxygen species; oxidative stress; oxidant; cardiovascular;
   biomarkers
ID SPIN-RESONANCE SPECTROSCOPY; ASYMMETRIC DIMETHYLARGININE; METABOLIC
   SYNDROME; INFLAMMATION; MYELOPEROXIDASE; DYSFUNCTION; CHILDREN; HEART;
   DAMAGE; ANTIOXIDANTS
AB Cardiovascular disease (CVD) remains the leading cause of death globally, with unhealthy lifestyles today greatly increasing the risk. Over the decades, scientific investigation has been carried out on reactive oxygen species (ROS) and their resultant oxidative stress based on their changes made on biological targets such as lipids, proteins, and DNA. Since the existing clinical studies with antioxidants failed to provide relevant findings on CVD prediction, the focus has shifted towards recognition of oxidised targets as biomarkers to predict prognosis and response to accurate treatment. The identification of redox markers could help clinicians in providing risk stratification for CVD events beyond the traditional prognostic and diagnostic targets. This review will focus on how oxidant-related parameters can be applied as biomarkers for CVD based on recent clinical evidence.
C1 [Kong, Amanda Shen-Yee; Sathiya, Maran] Monash Univ Malaysia, Sch Pharm, Jalan Lagoon Selatan, Bandar Sunway 47500, Subang Jaya, Malaysia.
   [Lai, Kok Song; Lim, Swee Hua Erin] Abu Dhabi Womens Coll, Higher Coll Technol, Hlth Sci Div, Abu Dhabi 41012, U Arab Emirates.
   [Hee, Cheng-Wan] INTI Int Univ, Fac Hlth & Life Sci, Putra Nilai 71800, Nilai, Malaysia.
   [Loh, Jiun Yan] UCSI Univ, Ctr Res Adv Aquaculture CORAA, Kuala Lumpur 56000, Malaysia.
C3 Monash University; Monash University Malaysia; Higher Colleges of
   Technology - United Arab Emirates; INTI International University; UCSI
   University
RP Sathiya, M (corresponding author), Monash Univ Malaysia, Sch Pharm, Jalan Lagoon Selatan, Bandar Sunway 47500, Subang Jaya, Malaysia.
EM kong.amanda0811@gmail.com; lkoksong@hct.ac.ae;
   wanhee.cheng@newinti.edu.my; lohjy@ucsiuniversity.edu.my;
   lerin@hct.ac.ae; sathiya.maran@monash.edu
RI Loh, Jiun/AAI-9818-2020; Lai, Kok/AAR-8772-2020; Kong, Amanda
   Shen-Yee/GOV-5527-2022
OI Kong, Amanda Shen-Yee/0000-0002-6967-6928; Loh, Jiun
   Yan/0000-0003-2857-9184; Maran, Sathiya/0000-0001-5617-901X
CR Afshinnia F, 2017, AM J NEPHROL, V46, P73, DOI 10.1159/000477766
   Aimo A, 2020, EUR J PREV CARDIOL, V27, P494, DOI 10.1177/2047487319870344
   Alamdari DH, 2008, CLIN BIOCHEM, V41, P375, DOI 10.1016/j.clinbiochem.2007.12.008
   Amioka N, 2019, J CARDIOL, V74, P258, DOI 10.1016/j.jjcc.2019.02.012
   Anderson C, 2018, FREE RADICAL BIO MED, V115, P229, DOI 10.1016/j.freeradbiomed.2017.12.006
   Appel D, 2020, J INT MED RES, V48, DOI 10.1177/0300060520940450
   ARAUJO FB, 1995, ATHEROSCLEROSIS, V117, P61, DOI 10.1016/0021-9150(94)05558-Z
   Bakker SJL, 2000, ATHEROSCLEROSIS, V148, P17, DOI 10.1016/S0021-9150(99)00329-9
   Barbin LE, 2008, J ENDODONT, V34, P1508, DOI 10.1016/j.joen.2008.08.032
   Biswas SK, 2007, FREE RADICAL RES, V41, P216, DOI 10.1080/10715760601059672
   Blaskovicová J, 2018, ELECTROANAL, V30, P698, DOI 10.1002/elan.201700648
   Boarescu PM, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23031438
   Cai H, 2019, FREE RADICAL BIO MED, V134, P526, DOI 10.1016/j.freeradbiomed.2019.01.044
   Calmarza P, 2018, ARCH CARDIOL MEX, V88, P391, DOI 10.1016/j.acmx.2017.11.003
   Castro-Diehl C, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0251308
   Charkiewicz AE, 2021, ADV MED SCI-POLAND, V66, P185, DOI 10.1016/j.advms.2021.02.004
   Chen QM, 2018, PHYSIOL GENOMICS, V50, P77, DOI 10.1152/physiolgenomics.00041.2017
   Cordts K, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9070277
   Csonka C, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/3863726
   Csont T, 2007, CARDIOVASC RES, V76, P100, DOI 10.1016/j.cardiores.2007.06.006
   Dai HJ, 2022, EUR HEART J-QUAL CAR, V8, P50, DOI 10.1093/ehjqcco/qcaa076
   Daiber A, 2021, REDOX BIOL, V42, DOI 10.1016/j.redox.2021.101875
   Duanghathaipornsuk S, 2021, BIOSENSORS-BASEL, V11, DOI 10.3390/bios11020030
   Erdogan M, 2020, TURK J MED SCI, V50, P1323, DOI 10.3906/sag-1909-183
   Forman HJ, 2021, NAT REV DRUG DISCOV, V20, P689, DOI 10.1038/s41573-021-00233-1
   Galougahi KK, 2015, EUR HEART J, V36, P1576, DOI 10.1093/eurheartj/ehv126
   Ganjali S, 2021, J CLIN MED, V10, DOI 10.3390/jcm10245867
   Gao F, 2022, ESC HEART FAIL, V9, P2259, DOI 10.1002/ehf2.13815
   González-Jiménez E, 2016, BIOFACTORS, V42, P163, DOI 10.1002/biof.1258
   Hartley A, 2019, TRENDS CARDIOVAS MED, V29, P22, DOI 10.1016/j.tcm.2018.05.010
   He WW, 2014, J FOOD DRUG ANAL, V22, P49, DOI 10.1016/j.jfda.2014.01.004
   Petek TH, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11050894
   Ho E, 2013, REDOX BIOL, V1, P483, DOI 10.1016/j.redox.2013.07.006
   Jiang SY, 2022, ANAL CHEM, V94, P5634, DOI 10.1021/acs.analchem.1c05647
   Kalyanaraman B, 2018, REDOX BIOL, V15, P347, DOI 10.1016/j.redox.2017.12.012
   Kelly Aaron S, 2006, J Cardiometab Syndr, V1, P248, DOI 10.1111/j.1559-4564.2006.05758.x
   Mangge H, 2014, WORLD J CARDIOL, V6, P462, DOI 10.4330/wjc.v6.i6.462
   Mathew AV, 2018, DIABETES CARE, V41, P2431, DOI 10.2337/dc18-0049
   Miripour ZS, 2022, J PHARMACEUT BIOMED, V209, DOI 10.1016/j.jpba.2021.114488
   Nishihara T, 2021, J AM HEART ASSOC, V10, DOI 10.1161/JAHA.120.016765
   Olza J, 2015, ANN NUTR METAB, V66, P72, DOI 10.1159/000369981
   Omran Mohamed M, 2018, J Immunoassay Immunochem, V39, P337, DOI 10.1080/15321819.2018.1492423
   Pellegrino Daniela, 2016, Diseases, V4, DOI 10.3390/diseases4010011
   Peoples JN, 2019, EXP MOL MED, V51, DOI 10.1038/s12276-019-0355-7
   Petrulioniene Z, 2019, J CLIN LIPIDOL, V13, P887, DOI 10.1016/j.jacl.2019.09.009
   Premkumar J, 2020, CHEMMEDCHEM, V15, P1187, DOI 10.1002/cmdc.202000084
   Ramachandra CJA, 2021, FREE RADICAL BIO MED, V166, P297, DOI 10.1016/j.freeradbiomed.2021.02.040
   Ramachandra CJA, 2022, CARDIOVASC RES, V118, P517, DOI 10.1093/cvr/cvab077
   Ramachandra CJA, 2020, ANTIOXID REDOX SIGN, V32, P1135, DOI 10.1089/ars.2019.7971
   Martínez SR, 2016, CHEM PHARM BULL, V64, P135, DOI 10.1248/cpb.c15-00682
   Romuk E, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/9246138
   Schmidt HHHW, 2015, ANTIOXID REDOX SIGN, V23, P1130, DOI 10.1089/ars.2015.6393
   Seckin D, 2006, DIABETES RES CLIN PR, V73, P191, DOI 10.1016/j.diabres.2006.01.001
   Senoner T, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092090
   Sharma G, 2013, FREE RADICAL BIO MED, V55, P54, DOI 10.1016/j.freeradbiomed.2012.09.012
   Shields HJ, 2021, FRONT CELL DEV BIOL, V9, DOI 10.3389/fcell.2021.628157
   Sies H, 2017, ANNU REV BIOCHEM, V86, P715, DOI 10.1146/annurev-biochem-061516-045037
   Singh Shiv Vardan, 2016, Journal of Basic and Clinical Physiology and Pharmacology, V27, P121, DOI 10.1515/jbcpp-2015-0017
   Sladowska-Kozlowska J, 2015, PEDIATR NEPHROL, V30, P2189, DOI 10.1007/s00467-015-3164-9
   Soubhye J, 2020, EXPERT OPIN THER PAT, V30, P595, DOI 10.1080/13543776.2020.1780210
   Stokes KY, 2002, FREE RADICAL BIO MED, V33, P1026, DOI 10.1016/S0891-5849(02)01015-8
   Stoppa-Vaucher S, 2012, OBESITY, V20, P1662, DOI 10.1038/oby.2012.85
   Tsutsui H, 2011, AM J PHYSIOL-HEART C, V301, pH2181, DOI 10.1152/ajpheart.00554.2011
   Utsumi H, 2006, J PHARMACOL EXP THER, V317, P228, DOI 10.1124/jpet.105.095166
   Varga ZV, 2013, J MOL CELL CARDIOL, V62, P111, DOI 10.1016/j.yjmcc.2013.05.009
   Wang GS, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0193782
   Wang WJ, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9121292
   Wang XS, 2016, ARCH BIOCHEM BIOPHYS, V612, P103, DOI 10.1016/j.abb.2016.10.013
   Wojtala A., 2014, METHODS ENZYMOLOGY C
   World Health Organisation, Noncommunicable diseases
   Xu H, 2019, CHIN J INTEGR MED, V25, P327, DOI 10.1007/s11655-019-2701-y
   Xuan Y, 2019, EUR J EPIDEMIOL, V34, P471, DOI 10.1007/s10654-018-0457-x
   Xuan Y, 2018, INT J CARDIOL, V273, P223, DOI 10.1016/j.ijcard.2018.08.002
   Ye JF, 2021, NITRIC OXIDE-BIOL CH, V109, P50, DOI 10.1016/j.niox.2021.03.002
   Yilmaz MI, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-65528-6
   Zhang N, 2022, FRONT MED-LAUSANNE, V9, DOI 10.3389/fmed.2022.828174
   Zhang SY, 2021, PHYTOTHER RES, V35, P2945, DOI 10.1002/ptr.7002
   Zhao X, 2018, PERS MED, V15, P521, DOI 10.2217/pme-2018-0046
   Zhao X, 2018, BIOMARKERS, V23, P647, DOI 10.1080/1354750X.2018.1474256
NR 79
TC 21
Z9 22
U1 2
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUN
PY 2022
VL 11
IS 6
AR 1175
DI 10.3390/antiox11061175
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 2K1AN
UT WOS:000816076300001
PM 35740071
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vo, T
   Hardy, DB
AF Vo, Thin
   Hardy, Daniel B.
TI Molecular mechanisms underlying the fetal programming of adult disease
SO JOURNAL OF CELL COMMUNICATION AND SIGNALING
LA English
DT Review
DE Fetal Programming; Epigenetics; microRNA; Posttranslational Histone
   Modifications; DNA Methylation; ER Stress; Nuclear Receptors
ID ENDOPLASMIC-RETICULUM STRESS; ACTIVATED-RECEPTOR-GAMMA; LOW-PROTEIN
   DIET; INTRAUTERINE GROWTH RESTRICTION; HEPATIC PHOSPHOENOLPYRUVATE
   CARBOXYKINASE; FOLIC-ACID SUPPLEMENTATION; SYSTOLIC BLOOD-PRESSURE;
   ISCHEMIC-HEART-DISEASE; ENZYME GENE-EXPRESSION; GLUCOCORTICOID-RECEPTOR
AB Adverse events in utero can be critical in determining quality of life and overall health. It is estimated that up to 50 % of metabolic syndrome diseases can be linked to an adverse fetal environment. However, the mechanisms linking impaired fetal development to these adult diseases remain elusive. This review uncovers some of the molecular mechanisms underlying how normal physiology may be impaired in fetal and postnatal life due to maternal insults in pregnancy. By understanding the mechanisms, which include epigenetic, transcriptional, endoplasmic reticulum (ER) stress, and reactive oxygen species (ROS), we also highlight how intervention in fetal and neonatal life may be able to prevent these diseases long-term.
C1 [Vo, Thin; Hardy, Daniel B.] Univ Western Ontario, Dept Physiol & Pharmacol, London, ON N6A 5C1, Canada.
   [Vo, Thin; Hardy, Daniel B.] Univ Western Ontario, Dept Obstet & Gynecol, London, ON N6A 5C1, Canada.
   [Vo, Thin; Hardy, Daniel B.] Childrens Hlth Res Inst, London, ON N6C 2V5, Canada.
   [Vo, Thin; Hardy, Daniel B.] Lawson Hlth Res Inst, London, ON N6A 4V2, Canada.
C3 Western University (University of Western Ontario); Western University
   (University of Western Ontario); Western University (University of
   Western Ontario); University Western Ontario Hospital
RP Hardy, DB (corresponding author), Univ Western Ontario, Dept Physiol & Pharmacol, London, ON N6A 5C1, Canada.
EM daniel.hardy@schulich.uwo.ca
RI Hardy, Daniel/GYU-8976-2022
OI Hardy, Daniel/0000-0001-5445-273X; Vo, Thin Xuan/0000-0002-2131-5701
FU CIHR Operating Grant; Natural Sciences and Engineering Research Council
   of Canada
FX Supported by: CIHR Operating Grant and Natural Sciences and Engineering
   Research Council of Canada
CR Altmann S, 2012, EPIGENETICS-US, V7, P239, DOI 10.4161/epi.7.3.19183
   Angione AR, 2011, SKELET MUSCLE, V1, DOI 10.1186/2044-5040-1-33
   APFEL R, 1994, MOL CELL BIOL, V14, P7025, DOI 10.1128/MCB.14.10.7025
   Barak Y, 2002, P NATL ACAD SCI USA, V99, P303, DOI 10.1073/pnas.012610299
   BARKER DJP, 1990, BRIT MED J, V301, P1111, DOI 10.1136/bmj.301.6761.1111
   Barker DJP, 2002, INT J EPIDEMIOL, V31, P1235, DOI 10.1093/ije/31.6.1235
   Barnes PJ, 1998, CLIN SCI, V94, P557, DOI 10.1042/cs0940557
   Barth TK, 2010, TRENDS BIOCHEM SCI, V35, P618, DOI 10.1016/j.tibs.2010.05.006
   Bateson P, 2004, NATURE, V430, P419, DOI 10.1038/nature02725
   Bayol SA, 2005, J PHYSIOL-LONDON, V567, P951, DOI 10.1113/jphysiol.2005.088989
   Begum G, 2012, FASEB J, V26, P1694, DOI 10.1096/fj.11-198762
   BENEDIKTSSON R, 1993, LANCET, V341, P339, DOI 10.1016/0140-6736(93)90138-7
   Bertram C, 2001, ENDOCRINOLOGY, V142, P2841, DOI 10.1210/en.142.7.2841
   Bispham J, 2005, ENDOCRINOLOGY, V146, P3943, DOI 10.1210/en.2005-0246
   Blondeau B, 2001, AM J PHYSIOL-ENDOC M, V281, pE592, DOI 10.1152/ajpendo.2001.281.3.E592
   Brennecke J, 2005, PLOS BIOL, V3, P404, DOI 10.1371/journal.pbio.0030085
   Burdge GC, 2008, BRIT J NUTR, V99, P540, DOI 10.1017/S0007114507815819
   Burdge GC, 2007, BRIT J NUTR, V97, P1036, DOI 10.1017/S0007114507682920
   Burdge GC, 2007, BRIT J NUTR, V97, P435, DOI 10.1017/S0007114507352392
   Burdge GC, 2009, J NUTR, V139, P1054, DOI 10.3945/jn.109.104653
   Carter AM, 2000, PLACENTA, V21, pS31, DOI 10.1053/plac.1999.0513
   CASCIO S, 1991, DEVELOPMENT, V113, P217
   Chamson-Reig A, 2009, EXP BIOL MED, V234, P1425, DOI 10.3181/0902-RM-69
   Chinetti G, 2000, INFLAMM RES, V49, P497, DOI 10.1007/s000110050622
   Cooper WN, 2012, FASEB J, V26, P1782, DOI 10.1096/fj.11-192708
   Covarrubias L, 2008, DEV BIOL, V320, P1, DOI 10.1016/j.ydbio.2008.04.041
   Curhan GC, 1996, CIRCULATION, V94, P1310, DOI 10.1161/01.CIR.94.6.1310
   Curhan GC, 1996, CIRCULATION, V94, P3246, DOI 10.1161/01.CIR.94.12.3246
   DAHRI S, 1991, DIABETES, V40, P115, DOI 10.2337/diab.40.2.S115
   Desai M, 1997, BIOL REV, V72, P329, DOI 10.1017/S0006323196005026
   Duffield JA, 2009, PEDIATR RES, V66, P59, DOI 10.1203/PDR.0b013e3181a7c121
   Dumortier O, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025576
   Einstein F, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008887
   Farmer SR, 2006, CELL METAB, V4, P263, DOI 10.1016/j.cmet.2006.07.001
   Fluhr JW, 2005, J INVEST DERMATOL, V125, P1206, DOI 10.1111/j.0022-202X.2005.23964.x
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   Franco MD, 2002, J CARDIOVASC PHARM, V40, P501, DOI 10.1097/00005344-200210000-00002
   Gesina E, 2004, DIABETES, V53, P2322, DOI 10.2337/diabetes.53.9.2322
   Giussani DA, 2001, PEDIATR RES, V49, P490, DOI 10.1203/00006450-200104000-00009
   Giussani DA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031017
   Gómez-Valadés AG, 2008, DIABETES, V57, P2199, DOI 10.2337/db07-1087
   GREENGARD O, 1972, J CELL BIOL, V52, P261, DOI 10.1083/jcb.52.2.261
   Gregor MF, 2009, DIABETES, V58, P693, DOI 10.2337/db08-1220
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Gruppuso PA, 1997, IN VITRO CELL DEV-AN, V33, P562
   Gualdi R, 1996, GENE DEV, V10, P1670, DOI 10.1101/gad.10.13.1670
   Guan HY, 2005, AM J PHYSIOL-ENDOC M, V288, pE663, DOI 10.1152/ajpendo.00461.2004
   Habib S, 2011, AM J HYPERTENS, V24, P96, DOI 10.1038/ajh.2010.177
   HALES CN, 1991, BMJ-BRIT MED J, V303, P1019, DOI 10.1136/bmj.303.6809.1019
   Hewitt KN, 2004, ENDOCRINOLOGY, V145, P1842, DOI 10.1210/en.2003-1369
   Hewitt KN, 2003, ENDOCRINOLOGY, V144, P3895, DOI 10.1210/en.2003-0244
   Hockaday TD, 2003, DIABETOLOGIA, V35, P595
   Hockaday TDR, 2003, DIABETOLOGIA, V46, P303, DOI 10.1007/s00125-002-1024-1
   Huxley R, 2007, AM J CLIN NUTR, V85, P1244, DOI 10.1093/ajcn/85.5.1244
   Imai T, 2004, P NATL ACAD SCI USA, V101, P4543, DOI 10.1073/pnas.0400356101
   ISSEMANN I, 1990, NATURE, V347, P645, DOI 10.1038/347645a0
   Jackson AA, 2002, CLIN SCI, V103, P633, DOI 10.1042/cs1030633
   Janowski BA, 1996, NATURE, V383, P728, DOI 10.1038/383728a0
   Jaquet D, 2000, J CLIN ENDOCR METAB, V85, P1401, DOI 10.1210/jc.85.4.1401
   Jenuwein T, 2001, SCIENCE, V293, P1074, DOI 10.1126/science.1063127
   Karowicz-Bilinska Agata, 2002, Med Sci Monit, V8, pCR211
   Ke X, 2006, PHYSIOL GENOMICS, V25, P16, DOI 10.1152/physiolgenomics.00093.2005
   KELLER H, 1993, P NATL ACAD SCI USA, V90, P2160, DOI 10.1073/pnas.90.6.2160
   Keyes LE, 2003, PEDIATR RES, V54, P20, DOI 10.1203/01.PDR.0000069846.64389.DC
   Khorram O, 2010, AM J PHYSIOL-REG I, V298, pR1366, DOI 10.1152/ajpregu.00704.2009
   Kim YI, 1997, AM J CLIN NUTR, V65, P46, DOI 10.1093/ajcn/65.1.46
   KLIEWER SA, 1992, NATURE, V358, P771, DOI 10.1038/358771a0
   KNIGHT DB, 1994, AM J OBSTET GYNECOL, V171, P11, DOI 10.1016/S0002-9378(94)70070-2
   Kung JWC, 2010, J BIOMED BIOTECHNOL, DOI 10.1155/2010/984248
   LANGLEY SC, 1994, COMP BIOCHEM PHYS A, V109, P223, DOI 10.1016/0300-9629(94)90124-4
   LangleyEvans SC, 1997, J HYPERTENS, V15, P537, DOI 10.1097/00004872-199715050-00010
   Law MR, 2003, BRIT MED J, V326, P1423, DOI 10.1136/bmj.326.7404.1423
   Leader JE, 2006, ANN NY ACAD SCI, V1089, P73, DOI 10.1196/annals.1386.047
   Lefebvre P, 2006, J CLIN INVEST, V116, P571, DOI 10.1172/JCI27989
   Lehmann JM, 1997, J BIOL CHEM, V272, P3137, DOI 10.1074/jbc.272.6.3137
   Lenzen S, 1996, FREE RADICAL BIO MED, V20, P463, DOI 10.1016/0891-5849(96)02051-5
   Lesage J, 2001, ENDOCRINOLOGY, V142, P1692, DOI 10.1210/en.142.5.1692
   Levitt NS, 1996, NEUROENDOCRINOLOGY, V64, P412, DOI 10.1159/000127146
   Lewis RM, 2001, BRIT J NUTR, V85, P193, DOI 10.1079/BJN2000247
   Li TG, 2008, J LIPID RES, V49, P1981, DOI 10.1194/jlr.M800140-JLR200
   LIGGINS GC, 1972, PEDIATRICS, V50, P515
   Lillycrop KA, 2005, J NUTR, V135, P1382, DOI 10.1093/jn/135.6.1382
   Lillycrop KA, 2008, BRIT J NUTR, V100, P278, DOI 10.1017/S0007114507894438
   Lillycrop KA, 2007, BRIT J NUTR, V97, P1064, DOI 10.1017/S000711450769196X
   Liu JB, 2011, MOL BIOL REP, V38, P3849, DOI 10.1007/s11033-010-0500-9
   Lloyd-Jones D, 2010, CIRCULATION, V121, P948, DOI 10.1161/CIRCULATIONAHA.109.192666
   Lopez AD, 2006, LANCET, V367, P1747, DOI 10.1016/S0140-6736(06)68770-9
   Lu NZ, 2005, MOL CELL, V18, P331, DOI 10.1016/j.molcel.2005.03.025
   Lucas A, 1996, BRIT J NUTR, V76, P605, DOI 10.1079/BJN19960066
   Lund EG, 2006, BIOCHEM PHARMACOL, V71, P453, DOI 10.1016/j.bcp.2005.11.004
   Luquet S, 2003, FASEB J, V17, P2299, DOI 10.1096/fj.03-0269fje
   MANGELSDORF DJ, 1995, CELL, V83, P835, DOI 10.1016/0092-8674(95)90199-X
   Manolio TA, 2009, NATURE, V461, P747, DOI 10.1038/nature08494
   Marmorstein R, 2009, BBA-GENE REGUL MECH, V1789, P58, DOI 10.1016/j.bbagrm.2008.07.009
   McGuire S, 2011, ADV NUTR, V2, P368, DOI 10.3945/an.111.000497
   Michalik L, 2006, PHARMACOL REV, V58, P726, DOI 10.1124/pr.58.4.5
   Mitro N, 2007, HEPATOLOGY, V46, P885, DOI 10.1002/hep.21819
   Mitro N, 2007, NATURE, V445, P219, DOI 10.1038/nature05449
   Moore LG, 1998, YEARB PHYS ANTHROPOL, V41, P25
   Mouillet JF, 2010, PLACENTA, V31, P781, DOI 10.1016/j.placenta.2010.07.001
   Muhlhausler BS, 2007, ENDOCRINOLOGY, V148, P878, DOI 10.1210/en.2006-1115
   Murrell A, 2001, EMBO REP, V2, P1101, DOI 10.1093/embo-reports/kve248
   NAKAZONO K, 1991, P NATL ACAD SCI USA, V88, P10045, DOI 10.1073/pnas.88.22.10045
   Nestel P, 2007, ASIA PAC J CLIN NUTR, V16, P362
   Nijland MJ, 2010, J PHYSIOL-LONDON, V588, P1349, DOI 10.1113/jphysiol.2009.184168
   Nilsson PM, 1997, J HYPERTENS, V15, P1627, DOI 10.1097/00004872-199715120-00064
   Nyirenda MJ, 1998, J CLIN INVEST, V101, P2174, DOI 10.1172/JCI1567
   Oakley RH, 1996, J BIOL CHEM, V271, P9550, DOI 10.1074/jbc.271.16.9550
   Ogden CL, 2012, JAMA-J AM MED ASSOC, V307, P483, DOI [10.1001/jama.2012.39, 10.1001/jama.2012.40]
   Ozaki T, 2001, J PHYSIOL-LONDON, V530, P141, DOI 10.1111/j.1469-7793.2001.0141m.x
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Parimi PS, 2004, PEDIATR RES, V56, P423, DOI 10.1203/01.PDR.0000136277.10365.84
   Peters JM, 2000, MOL CELL BIOL, V20, P5119, DOI 10.1128/MCB.20.14.5119-5128.2000
   Peterside IE, 2003, AM J PHYSIOL-ENDOC M, V285, pE1258, DOI 10.1152/ajpendo.00437.2002
   Petrik J, 1999, ENDOCRINOLOGY, V140, P4861, DOI 10.1210/en.140.10.4861
   Pinney SE, 2011, DIABETOLOGIA, V54, P2606, DOI 10.1007/s00125-011-2250-1
   Prüfer K, 2007, J CELL BIOCHEM, V100, P69, DOI 10.1002/jcb.21006
   Raab EL, 2009, AM J PHYSIOL-REG I, V297, pR1785, DOI 10.1152/ajpregu.00519.2009
   RAY A, 1994, P NATL ACAD SCI USA, V91, P752, DOI 10.1073/pnas.91.2.752
   Reckelhoff JF, 2001, HYPERTENSION, V37, P1199, DOI 10.1161/01.HYP.37.5.1199
   Rees WD, 2000, J NUTR, V130, P1821, DOI 10.1093/jn/130.7.1821
   Regnault TRH, 2010, PPAR RES, V2010, DOI 10.1155/2010/129173
   Repa JJ, 2000, ANNU REV CELL DEV BI, V16, P459, DOI 10.1146/annurev.cellbio.16.1.459
   Reynolds RM, 2010, J STEROID BIOCHEM, V122, P3, DOI 10.1016/j.jsbmb.2010.01.009
   Rhen T, 2005, NEW ENGL J MED, V353, P1711, DOI 10.1056/NEJMra050541
   Robertson RP, 2003, DIABETES, V52, P581, DOI 10.2337/diabetes.52.3.581
   Samuelsson AM, 2008, HYPERTENSION, V51, P383, DOI 10.1161/HYPERTENSIONAHA.107.101477
   Sapolsky RM, 2000, ENDOCR REV, V21, P55, DOI 10.1210/er.21.1.55
   Schaiff WT, 2007, ENDOCRINOLOGY, V148, P3625, DOI 10.1210/en.2007-0211
   Schuler M, 2006, CELL METAB, V4, P407, DOI 10.1016/j.cmet.2006.10.003
   Seckl JR, 2004, EUR J ENDOCRINOL, V151, pU49, DOI 10.1530/eje.0.151u049
   Simmons R, 2005, TRENDS ENDOCRIN MET, V16, P390, DOI 10.1016/j.tem.2005.08.004
   Simmons RA, 2005, J BIOL CHEM, V280, P28785, DOI 10.1074/jbc.M505695200
   Sohi G, 2012, REPROD SCI, V19, p91A
   Sohi G, 2011, REPROD SCI, V18, p220A
   Sohi G, 2011, MOL ENDOCRINOL, V25, P785, DOI 10.1210/me.2010-0395
   SONG C, 1994, P NATL ACAD SCI USA, V91, P10809, DOI 10.1073/pnas.91.23.10809
   Stevens A, 2010, ENDOCRINOLOGY, V151, P3652, DOI 10.1210/en.2010-0094
   Stoffers DA, 2003, DIABETES, V52, P734, DOI 10.2337/diabetes.52.3.734
   Talens RP, 2010, FASEB J, V24, P3135, DOI 10.1096/fj.09-150490
   Talukdar S, 2006, J LIPID RES, V47, P2451, DOI 10.1194/jlr.M600276-JLR200
   Thomassin H, 2001, EMBO J, V20, P1974, DOI 10.1093/emboj/20.8.1974
   Thorn SR, 2009, ENDOCRINOLOGY, V150, P3021, DOI 10.1210/en.2008-1789
   Tiedge M, 1997, DIABETES, V46, P1733, DOI 10.2337/diabetes.46.11.1733
   TONTONOZ P, 1994, GENE DEV, V8, P1224, DOI 10.1101/gad.8.10.1224
   Torrens C, 2006, HYPERTENSION, V47, P982, DOI 10.1161/01.HYP.0000215580.43711.d1
   Unterberger A, 2009, J MED PRIMATOL, V38, P219, DOI 10.1111/j.1600-0684.2008.00320.x
   VALERA A, 1994, P NATL ACAD SCI USA, V91, P9151, DOI 10.1073/pnas.91.19.9151
   Valtat B, 2011, DIABETOLOGIA, V54, P350, DOI 10.1007/s00125-010-1898-2
   van Straten EME, 2010, AM J PHYSIOL-REG I, V298, pR275, DOI 10.1152/ajpregu.00413.2009
   Vo TX, 2012, REPROD SCI, V19, p118A
   Von Bergen NH, 2009, CLIN SCI, V116, P659, DOI 10.1042/CS20080474
   Wang YX, 2004, PLOS BIOL, V2, P1532, DOI 10.1371/journal.pbio.0020294
   Wang ZH, 2009, AM J PHYSIOL-HEART C, V296, pH1321, DOI 10.1152/ajpheart.00440.2008
   Waterland RA, 2006, J NUTR, V136, p1706S, DOI 10.1093/jn/136.6.1706S
   Whorwood CB, 2001, ENDOCRINOLOGY, V142, P2854, DOI 10.1210/en.142.7.2854
   WILLY PJ, 1995, GENE DEV, V9, P1033, DOI 10.1101/gad.9.9.1033
   WILSON MJ, 1984, BIOCHEM J, V218, P987, DOI 10.1042/bj2180987
   Woodall SM, 1996, PEDIATR RES, V40, P438, DOI 10.1203/00006450-199609000-00012
   Woods LL, 2004, KIDNEY INT, V65, P1339, DOI 10.1111/j.1523-1755.2004.00511.x
   Xu CW, 2010, EUR J CANCER, V46, P2828, DOI 10.1016/j.ejca.2010.06.127
   Yamagata K, 1996, NATURE, V384, P458, DOI 10.1038/384458a0
   Yan X, 2011, BIOL REPROD, V85, P172, DOI 10.1095/biolreprod.110.089649
   YOUNG BK, 1980, AM J OBSTET GYNECOL, V138, P203, DOI 10.1016/0002-9378(80)90036-8
   Yung HW, 2012, FASEB J, V26, P1970, DOI 10.1096/fj.11-190082
   Yung HW, 2008, AM J PATHOL, V173, P451, DOI 10.2353/ajpath.2008.071193
   Zhang JL, 2005, AM J PHYSIOL-REG I, V288, pR104, DOI 10.1152/ajpregu.00343.2004
   Zhang JL, 2009, BMC GENOMICS, V10, DOI 10.1186/1471-2164-10-478
   Zhang ZD, 2004, GENOME RES, V14, P580, DOI 10.1101/gr.2160004
NR 169
TC 36
Z9 48
U1 0
U2 5
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1873-9601
EI 1873-961X
J9 J CELL COMMUN SIGNAL
JI J. Cell Commun. Signal
PD AUG
PY 2012
VL 6
IS 3
BP 139
EP 153
DI 10.1007/s12079-012-0165-3
PG 15
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA V39ON
UT WOS:000209420400003
PM 22623025
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Rizzo, M
   Kotur-Stevuljevic, J
   Berneis, K
   Spinas, G
   Rini, GB
   Jelic-Ivanovic, Z
   Spasojevic-Kalimanovska, V
   Vekic, J
AF Rizzo, Manfredi
   Kotur-Stevuljevic, Jelena
   Berneis, Kaspar
   Spinas, Giatgen
   Rini, Giovam Battista
   Jelic-Ivanovic, Zorana
   Spasojevic-Kalimanovska, Vesna
   Vekic, Jelena
TI Atherogenic dyslipidemia and oxidative stress: a new look
SO TRANSLATIONAL RESEARCH
LA English
DT Review
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-ARTERY-DISEASE; INTIMA-MEDIA
   THICKNESS; NITRIC-OXIDE SYNTHASE; LDL PARTICLE-SIZE; LIPID-PEROXIDATION;
   METABOLIC SYNDROME; HEART-DISEASE; OXIDIZED LDL; CLINICAL-SIGNIFICANCE
AB Although results from in vitro studies and clinical trials demonstrate strong associations between oxidative stress and cardiovascular risk, to date still no convincing data are available to suggest that treatment with antioxidants might reduce vascular events. Oxidative modifications of low-density lipoproteins (LDL) represent an early stage of atherosclerosis, and small, dense LDL are more susceptible to oxidation than larger, more buoyant particles. Oxidized LDL are independent predictors of subclinical and clinical atherosclerosis. Recent studies suggested that novel therapeutic strategies may take into account the removal of such particles from circulation. Future research is required to explore the potential synergistic impact of markers of oxidative stress and atherogenic dyslipidemia, particularly small dense LDL, on cardiovascular risk. (Translational Research 2009; 153:217-223)
C1 Univ Palermo, Dept Internal Med & Emerging Dis, I-90127 Palermo, Italy.
   Fac Pharm, Inst Med Biochem, Belgrade, Serbia.
   Univ Zurich Hosp, Div Endocrinol Diabet & Clin Nutr, CH-8091 Zurich, Switzerland.
C3 University of Palermo; University of Belgrade; University of Zurich;
   University Zurich Hospital
RP Rizzo, M (corresponding author), Univ Palermo, Dipartimento Med Clin & Patol Emergenti, Via Vespro 141, I-90127 Palermo, Italy.
EM mrizzo@unipa.it
RI RIZZO, MANFREDI/GZL-0551-2022
OI RIZZO, Manfredi/0000-0002-9549-8504; Vekic, Jelena/0000-0001-7445-0504
FU Ministry of Science and Environmental Protection, Republic of Serbia
   [145036B]
FX Jelena Kotur-Stevuljevic, Zorana Jelic-Ivanovic, Vesna
   Spasojevic-Kalimanovska, and Jelena Vekic are supported by a grant from
   the Ministry of Science and Environmental Protection, Republic of Serbia
   (Project No. 145036B).
CR Aeberli I, 2007, AM J CLIN NUTR, V86, P1174, DOI 10.1093/ajcn/86.4.1174
   Akkus I, 1996, CLIN CHIM ACTA, V244, P173, DOI 10.1016/0009-8981(95)06192-4
   Albertini R., 2002, Current Molecular Medicine (Hilversum), V2, P579, DOI 10.2174/1566524023362177
   Alp NJ, 2004, ARTERIOSCL THROM VAS, V24, P413, DOI 10.1161/01.ATV.0000110785.96039.f6
   AUSTIN MA, 1990, CIRCULATION, V82, P495, DOI 10.1161/01.CIR.82.2.495
   Babior BM, 2002, ARCH BIOCHEM BIOPHYS, V397, P342, DOI 10.1006/abbi.2001.2642
   Barter P, 2006, EUR HEART J SUPPL, V8, pF47, DOI 10.1093/eurheartj/sul041
   Berneis K, 2005, METABOLISM, V54, P227, DOI 10.1016/j.metabol.2004.08.017
   Berneis K, 2007, J CLIN ENDOCR METAB, V92, P186, DOI 10.1210/jc.2006-1705
   Berneis KK, 2002, J LIPID RES, V43, P1363, DOI 10.1194/jlr.R200004-JLR200
   Bokemark L, 2001, J INTERN MED, V249, P59, DOI 10.1046/j.1365-2796.2001.00735.x
   BRIDGES AB, 1992, CLIN CARDIOL, V15, P169, DOI 10.1002/clc.4960150307
   Carmena R, 2005, AM HEART J, V150, P859, DOI 10.1016/j.ahj.2005.04.027
   Channon KM, 2002, J PHYSIOL PHARMACOL, V53, P515
   Clempus RE, 2006, CARDIOVASC RES, V71, P216, DOI 10.1016/j.cardiores.2006.02.033
   Cominacini L, 1997, FREE RADICAL BIO MED, V22, P117, DOI 10.1016/S0891-5849(96)00271-7
   Cyrus T, 2001, CIRCULATION, V103, P2277
   Dalle-Donne I, 2006, CLIN CHEM, V52, P601, DOI 10.1373/clinchem.2005.061408
   Galeano NF, 1998, J LIPID RES, V39, P1263
   Gazi I, 2006, METABOLISM, V55, P885, DOI 10.1016/j.metabol.2006.02.015
   Gazi IF, 2007, EXPERT OPIN BIOL TH, V7, P53, DOI 10.1517/14712598.7.1.53
   Gentile M, 2008, CLIN CHIM ACTA, V388, P179, DOI 10.1016/j.cca.2007.10.033
   Griendling KK, 2003, CIRCULATION, V108, P1912, DOI 10.1161/01.CIR.0000093660.86242.BB
   Griendling KK, 2000, CIRC RES, V86, P494, DOI 10.1161/01.RES.86.5.494
   GRIFFIN BA, 1990, ATHEROSCLEROSIS, V83, P59, DOI 10.1016/0021-9150(90)90131-2
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Guzik TJ, 2006, DRUG DISCOV TODAY, V11, P524, DOI 10.1016/j.drudis.2006.04.003
   HAFFNER SM, 1995, DIABETOLOGIA, V38, P1328
   Hallman DM, 2004, BIOMARKERS, V9, P190, DOI 10.1080/13547500410001720758
   Hansson GK, 2005, NEW ENGL J MED, V352, P1685, DOI 10.1056/NEJMra043430
   Harrison DG, 1997, CLIN CARDIOL, V20, P11
   Heermeier K, 2001, J AM SOC NEPHROL, V12, P456, DOI 10.1681/ASN.V123456
   Hulthe J, 2002, ARTERIOSCL THROM VAS, V22, P1162, DOI 10.1161/01.ATV.0000021150.63480.CD
   Inoue T, 2001, J AM COLL CARDIOL, V37, P775, DOI 10.1016/S0735-1097(00)01199-2
   Ishigaki Y, 2008, CIRCULATION, V118, P75, DOI 10.1161/CIRCULATIONAHA.107.745174
   Ishii H, 1996, J BIOL CHEM, V271, P8458, DOI 10.1074/jbc.271.14.8458
   Julius U, 2007, INT J CLIN PRACT, V61, P1798, DOI 10.1111/j.1742-1241.2007.01507.x
   Jung HH, 2004, AM J NEPHROL, V24, P537, DOI 10.1159/000081731
   Kaminski P. M., 1994, Microcirculation (New York), V1, P231, DOI 10.3109/10739689409146750
   KATSIKI N, 2009, CLIN NUTR IN PRESS
   Kotur-Stevuljevic J, 2007, CLIN BIOCHEM, V40, P181, DOI 10.1016/j.clinbiochem.2006.09.007
   Krauss RM, 2004, DIABETES CARE, V27, P1496, DOI 10.2337/diacare.27.6.1496
   Krayenbuehl PA, 2008, SWISS MED WKLY, V138, P275, DOI 2008/19/smw-12124
   Kutuk O, 2003, TRENDS MOL MED, V9, P549, DOI 10.1016/j.molmed.2003.10.007
   Lamarche B, 1999, DIABETES METAB, V25, P199
   Lambeth JD, 2004, NAT REV IMMUNOL, V4, P181, DOI 10.1038/nri1312
   Landmesser U, 2003, J CLIN INVEST, V111, P1201, DOI 10.1172/JCI200314172
   Landmesser U, 2000, CIRCULATION, V101, P2264, DOI 10.1161/01.CIR.101.19.2264
   Landray MJ, 1998, QJM-MON J ASSOC PHYS, V91, P345, DOI 10.1093/qjmed/91.5.345
   Liu ML, 2002, STROKE, V33, P1255, DOI 10.1161/01.STR.0000014924.29238.E1
   Mahapatra S, 1998, J Indian Med Assoc, V96, P39
   Matsuura E, 2008, AUTOIMMUN REV, V7, P558, DOI 10.1016/j.autrev.2008.04.018
   McNally JS, 2003, AM J PHYSIOL-HEART C, V285, pH2290, DOI 10.1152/ajpheart.00515.2003
   Meisinger C, 2005, CIRCULATION, V112, P651, DOI 10.1161/CIRCULATIONAHA.104.529297
   Memon L, 2006, TOHOKU J EXP MED, V209, P197, DOI 10.1620/tjem.209.197
   Miyazaki T, 2005, ATHEROSCLEROSIS, V179, P139, DOI 10.1016/j.atherosclerosis.2004.09.013
   Montuschi P, 2004, FASEB J, V18, P1791, DOI 10.1096/fj.04-2330rev
   Mueller CFH, 2005, ARTERIOSCL THROM VAS, V25, P274, DOI 10.1161/01.ATV.0000149143.04821.eb
   Nesto Richard W, 2005, Am J Cardiovasc Drugs, V5, P379, DOI 10.2165/00129784-200505060-00005
   O'Neal DN, 1998, ATHEROSCLEROSIS, V136, P1, DOI 10.1016/S0021-9150(97)00175-5
   OHARA Y, 1993, J CLIN INVEST, V91, P2546, DOI 10.1172/JCI116491
   Packard CJ, 2006, CURR OPIN LIPIDOL, V17, P412, DOI 10.1097/01.mol.0000236367.42755.c1
   Rankinen T, 2000, THROMB RES, V99, P453, DOI 10.1016/S0049-3848(00)00271-1
   Rizzo M, 2007, INT J CLIN PRACT, V61, P1949, DOI 10.1111/j.1742-1241.2007.01596.x
   Rizzo M, 2006, QJM-INT J MED, V99, P1, DOI 10.1093/qjmed/hci154
   Rizzo M, 2008, DIABETIC MED, V25, P1406, DOI 10.1111/j.1464-5491.2008.02613.x
   RIZZO M, 2009, INT J CARDI IN PRESS
   RIZZO M, 2009, CLIN ENDOCR IN PRESS
   Rizzo M, 2008, ARCH MED SCI, V4, P215
   Rizzo M, 2008, ATHEROSCLEROSIS, V197, P237, DOI 10.1016/j.atherosclerosis.2007.03.034
   Rizzo M, 2007, EUR J ENDOCRINOL, V156, P361, DOI 10.1530/EJE-06-0652
   Rizzo M, 2007, DIABETES-METAB RES, V23, P14, DOI 10.1002/dmrr.694
   Sacks FM, 2003, J CLIN ENDOCR METAB, V88, P4525, DOI 10.1210/jc.2003-030636
   Sattar N, 1998, ATHEROSCLEROSIS, V138, P229, DOI 10.1016/S0021-9150(98)00037-9
   Skoglund-Andersson C, 1999, ARTERIOSCL THROM VAS, V19, P2422, DOI 10.1161/01.ATV.19.10.2422
   Sorescu D, 2001, TRENDS CARDIOVAS MED, V11, P124, DOI 10.1016/S1050-1738(01)00097-4
   Spiekermann S, 2003, CIRCULATION, V107, P1383, DOI 10.1161/01.CIR.0000056762.69302.46
   Superko HR, 1996, CIRCULATION, V94, P2351, DOI 10.1161/01.CIR.94.10.2351
   Tarpey MM, 2004, AM J PHYSIOL-REG I, V286, pR431, DOI 10.1152/ajpregu.00361.2003
   Toshima S, 2000, ARTERIOSCL THROM VAS, V20, P2243, DOI 10.1161/01.ATV.20.10.2243
   Tribble DL, 2001, AM J MED, V110, P103, DOI 10.1016/S0002-9343(00)00700-2
   TRIBBLE DL, 1995, J LIPID RES, V36, P662
   Turrens JF, 2003, J PHYSIOL-LONDON, V552, P335, DOI 10.1113/jphysiol.2003.049478
   Uchida K, 2003, AMINO ACIDS, V25, P249, DOI 10.1007/s00726-003-0015-y
   van Tits LJH, 2004, J INVEST MED, V52, P177, DOI 10.1136/jim-52-03-32
   Vekic J, 2007, EUR J CLIN INVEST, V37, P715, DOI 10.1111/j.1365-2362.2007.01849.x
   Vekic J, 2009, ATHEROSCLEROSIS, V203, P236, DOI 10.1016/j.atherosclerosis.2008.05.047
   Wallenfeldt K, 2004, STROKE, V35, P2248, DOI 10.1161/01.STR.0000140629.65145.3c
   Wang XL, 1998, ARTERIOSCL THROM VAS, V18, P1915, DOI 10.1161/01.ATV.18.12.1915
   Watanabe T, 2004, METABOLISM, V53, P476, DOI 10.1016/j.metabol.2003.11.020
   Yamashita H, 2007, CIRC J, V71, P681, DOI 10.1253/circj.71.681
   Zhang RL, 2002, J BIOL CHEM, V277, P46116, DOI 10.1074/jbc.M209124200
NR 93
TC 109
Z9 118
U1 2
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1931-5244
EI 1878-1810
J9 TRANSL RES
JI Transl. Res.
PD MAY
PY 2009
VL 153
IS 5
BP 217
EP 223
DI 10.1016/j.trsl.2009.01.008
PG 7
WC Medical Laboratory Technology; Medicine, General & Internal; Medicine,
   Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology; General & Internal Medicine; Research &
   Experimental Medicine
GA 441GF
UT WOS:000265756600002
PM 19375682
DA 2025-06-11
ER

PT J
AU Kim, M
   Shin, D
AF Kim, Minyeong
   Shin, Dayeon
TI Effects of the Interaction Between Oxidative Balance Score and Polygenic
   Risk Scores on Incidence of Metabolic Syndrome in Middle-Aged Korean
   Adults
SO ANTIOXIDANTS
LA English
DT Article
DE metabolic syndrome; oxidative balance score; polygenic risk score
ID INSULIN-RESISTANCE; NATIONAL-HEALTH; STRESS STATUS; ASSOCIATION;
   POPULATION; PREVALENCE; VARIANTS; DISEASE; DIETARY; ATHEROSCLEROSIS
AB Oxidative stress is implicated in insulin resistance, obesity, and metabolic syndromes (MetSs). However, the interplay between oxidative stress and genetic predisposition during the development of MetS remains unclear. In this study, we aimed to investigate the effects of the interaction between oxidative balance score (OBS) and polygenic risk score (PRS) on the incidence of MetS in middle-aged Korean adults. We analyzed data from 25,879 participants aged >= 40 years from the Health Examinees Cohort of the Korean Genome and Epidemiology Study. The OBS was calculated using 11 antioxidant and five pro-oxidant factors. A genome-wide association study and clumping analysis identified 16 independent single-nucleotide polymorphisms associated with MetS that were used to calculate individual PRSs. Multivariable Cox proportional hazard models adjusted for confounding variables were used to assess the impact of OBS and PRS on the incidence of MetS. During a mean follow-up period of 4.3 years, we recorded 3153 cases of MetS. In both men and women, the group with the lowest OBS and a high PRS had a 1.50-fold (hazard ratio [HR] 1.50, 95% confidence interval [CI] 1.07-2.11) and 1.89-fold (HR 1.89, 95% CI 1.40-2.56) higher incidence, respectively, of MetS compared to those with the highest OBS and a low PRS. Among women with a high PRS, the HRs decreased significantly across OBS quintiles 1 through 5 (p for trend = 0.009). These findings suggest that managing the oxidative balance may be particularly crucial for individuals with a high genetic risk for MetS.
C1 [Kim, Minyeong; Shin, Dayeon] Inha Univ, Dept Food & Nutr, 100 Inha Ro, Incheon 22212, South Korea.
C3 Inha University
RP Shin, D (corresponding author), Inha Univ, Dept Food & Nutr, 100 Inha Ro, Incheon 22212, South Korea.
EM kmy000923@naver.com; dyshin@inha.ac.kr
OI Kim, Minyeong/0009-0000-4445-3827
FU National Research Foundation of Korea grant funded by the Korean
   Government (MSIT) [RS-2024-00340086]; National Research Foundation of
   Korea - Korean Government (MSIT)
FX This work was supported by a National Research Foundation of Korea grant
   funded by the Korean Government (MSIT) (RS-2024-00340086).
CR Ahn SeoEun Ahn SeoEun, 2017, Journal of Nutrition and Health, V50, P313, DOI 10.4163/jnh.2017.50.4.313
   Angelico F, 2023, INTERN EMERG MED, V18, P1007, DOI 10.1007/s11739-023-03226-7
   Bacchetti T, 2019, NUTRITION, V61, P164, DOI 10.1016/j.nut.2018.10.034
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Chainy GBN, 2020, FREE RADICAL RES, V54, P1, DOI 10.1080/10715762.2019.1702656
   Chen AQ, 2024, BBA-REV CANCER, V1879, DOI 10.1016/j.bbcan.2024.189175
   Chen K, 2024, FRONT NUTR, V11, DOI 10.3389/fnut.2024.1374992
   Chen ZS, 2021, G3-GENES GENOM GENET, V11, DOI 10.1093/g3journal/jkaa056
   임열리, 2003, Korean Journal of Family Medicine, V24, P135
   Choi SW, 2020, NAT PROTOC, V15, P2759, DOI 10.1038/s41596-020-0353-1
   Colak E, 2021, J MED BIOCHEM, V40, P1, DOI 10.5937/jomb0-24652
   Dandona P, 2010, EXP MOL MED, V42, P245, DOI 10.3858/emm.2010.42.4.033
   Dash C, 2015, AM J EPIDEMIOL, V181, P584, DOI 10.1093/aje/kwu318
   De Paoli M, 2021, AM J PATHOL, V191, P1490, DOI 10.1016/j.ajpath.2021.05.011
   de Sousa CV, 2017, SPORTS MED, V47, P277, DOI 10.1007/s40279-016-0566-1
   Dubois V, 2016, ENDOCRINOLOGY, V157, P648, DOI 10.1210/en.2015-1713
   Fernando SM, 2010, ENDOCRINOLOGY, V151, P3125, DOI 10.1210/en.2010-0018
   Forrester SJ, 2018, CIRC RES, V122, P877, DOI 10.1161/CIRCRESAHA.117.311401
   Ghanim H, 2009, DIABETES CARE, V32, P2281, DOI 10.2337/dc09-0979
   Gregorio KCR, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10010099
   Guardiola M, 2017, CURR ATHEROSCLER REP, V19, DOI 10.1007/s11883-017-0665-y
   Hadarits F, 2012, MOL BIOL REP, V39, P1949, DOI 10.1007/s11033-011-0942-8
   Han TS., 2015, Medicine, V43, P80, DOI DOI 10.1016/J.MPMED.2014.11.006
   Health Examinees Study Group, 2015, Asian Pac J Cancer Prev, V16, P1591
   Heinlein CA, 2002, ENDOCR REV, V23, P175, DOI 10.1210/er.23.2.175
   Ho NT, 2024, NUTR METAB CARDIOVAS, V34, P326, DOI 10.1016/j.numecd.2023.10.002
   Hosseini Z, 2016, NUTR RES REV, V29, P152, DOI 10.1017/S095442241600007X
   Huang MC, 2009, J FORMOS MED ASSOC, V108, P560, DOI 10.1016/S0929-6646(09)60374-0
   Iorga A, 2017, BIOL SEX DIFFER, V8, DOI 10.1186/s13293-017-0152-8
   Kapoor D, 2005, CLIN ENDOCRINOL, V63, P239, DOI 10.1111/j.1365-2265.2005.02299.x
   Katsimardou A, 2020, CURR HYPERTENS REV, V16, P12, DOI 10.2174/1573402115666190415161813
   Kefi R, 2017, ANN ENDOCRINOL-PARIS, V78, P146, DOI 10.1016/j.ando.2017.01.005
   Kim M, 2013, METABOLISM, V62, P554, DOI 10.1016/j.metabol.2012.10.006
   Kim Y, 2017, INT J EPIDEMIOL, V46, DOI 10.1093/ije/dyv316
   Kong S, 2019, BMC MED GENET, V20, DOI 10.1186/s12881-019-0830-y
   Lee G, 2022, LIPIDS HEALTH DIS, V21, DOI 10.1186/s12944-022-01736-5
   Lee HS, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/6873197
   Lee SR, 2013, INT J CARDIOL, V166, P633, DOI 10.1016/j.ijcard.2011.11.095
   Li J, 2009, MATURITAS, V63, P142, DOI 10.1016/j.maturitas.2009.03.008
   Liu YY, 2023, FRONT IMMUNOL, V14, DOI 10.3389/fimmu.2023.1139589
   Liu ZF, 2016, J DIABETES, V8, P324, DOI 10.1111/1753-0407.12296
   Lloyd-Jones LR, 2017, AM J HUM GENET, V100, P228, DOI 10.1016/j.ajhg.2016.12.008
   Lobene AJ, 2023, JACC-ASIA, V3, P503, DOI 10.1016/j.jacasi.2023.05.004
   Lobo RA, 2008, MATURITAS, V60, P10, DOI 10.1016/j.maturitas.2008.02.008
   Lu Y, 2024, FRONT NUTR, V11, DOI 10.3389/fnut.2024.1375060
   Mahjoub S, 2012, CASP J INTERN MED, V3, P386
   Masenga SK, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24097898
   Mayne ST, 2003, J NUTR, V133, p933S, DOI 10.1093/jn/133.3.933S
   Mirzababaei A, 2018, DIABETOL METAB SYNDR, V10, DOI 10.1186/s13098-018-0372-z
   Mohamed S.M., 2023, Food Chem Adv, V3, DOI 10.1016/j.focha.2023.100335
   Moon ME, 2024, EXP GERONTOL, V193, DOI 10.1016/j.exger.2024.112475
   Moon S, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-37832-9
   Nurmohamed NS, 2022, CARDIOVASC RES, V118, P2919, DOI 10.1093/cvr/cvab350
   Ouatou S, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-60
   Park HG, 2023, BMJ OPEN DIAB RES CA, V11, DOI 10.1136/bmjdrc-2023-003649
   Park S, 2023, NUTRITION, V111, DOI 10.1016/j.nut.2023.112007
   Park S, 2015, NUTRITION, V31, P111, DOI 10.1016/j.nut.2014.05.011
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Piko P, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms241210281
   Poljsak B, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/671539
   Povel CM, 2011, OBES REV, V12, P952, DOI 10.1111/j.1467-789X.2011.00907.x
   Povel CM, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-133
   Ranasinghe P, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4041-1
   Raut SK, 2023, MOL CELL BIOCHEM, V478, P185, DOI 10.1007/s11010-022-04496-z
   Roche HM, 2005, P NUTR SOC, V64, P371, DOI 10.1079/PNS2005445
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sánchez-Moreno C, 2011, J NUTR, V141, P380, DOI 10.3945/jn.110.130344
   Schwartz CC, 2004, J LIPID RES, V45, P1594, DOI 10.1194/jlr.M300511-JLR200
   Seo YS, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12091732
   Sies H, 2005, J NUTR, V135, P969, DOI 10.1093/jn/135.5.969
   Society of Metabolic Health Practitioners, 2022, Clinical practice guidelines for obesity 2022
   Son KY, 2015, LIPIDS HEALTH DIS, V14, DOI 10.1186/s12944-015-0111-5
   Srivastava R.K., 2015, J. Appl. Pharm. Sci, V5, P008, DOI [10.7324/JAPS.2015.50602, DOI 10.7324/JAPS.2015.50602]
   St-Pierre J, 2022, FRONT GENET, V13, DOI 10.3389/fgene.2022.900595
   Tao TT, 2022, BMC ENDOCR DISORD, V22, DOI 10.1186/s12902-022-00965-0
   Tian ZJ, 2024, medRxiv, DOI [10.1101/2024.03.04.24303751, 10.1101/2024.03.04.24303751, DOI 10.1101/2024.03.04.24303751]
   Uebi T, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0037803
   Valavanidis A, 2009, INT J ENV RES PUB HE, V6, P445, DOI 10.3390/ijerph6020445
   Wang HY, 2020, CLIN EXP HYPERTENS, V42, P81, DOI 10.1080/10641963.2019.1590383
   Wei J, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0130876
   Wranicz JK, 2005, INT J CARDIOL, V101, P105, DOI 10.1016/j.ijcard.2004.07.010
   Wu XL, 2010, J NUTR, V140, P1628, DOI 10.3945/jn.110.123927
   Xiong Y, 2021, AGING MALE, V24, P148, DOI 10.1080/13685538.2021.1998432
   Yan Q, 2023, J TRANSL MED, V21, DOI 10.1186/s12967-023-04361-7
   Yeh KH, 2022, GENES-BASEL, V13, DOI 10.3390/genes13081366
   Zhang H, 2024, METABOLISM, V160, DOI 10.1016/j.metabol.2024.155999
NR 86
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD DEC
PY 2024
VL 13
IS 12
AR 1556
DI 10.3390/antiox13121556
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA Q4D6M
UT WOS:001384212200001
PM 39765884
OA gold
DA 2025-06-11
ER

PT J
AU Leclercq, IA
   Morais, ADS
   Schroyen, B
   Van Hul, N
   Geerts, A
AF Leclercq, Isabelle A.
   Morais, Alain Da Silva
   Schroyen, Ben
   Van Hul, Noml
   Geerts, Albert
TI Insulin resistance in hepatocytes and sinusoidal liver cells: Mechanisms
   and consequences
SO JOURNAL OF HEPATOLOGY
LA English
DT Review
ID HEPATIC STELLATE CELLS; GLYCATION END-PRODUCTS; NONALCOHOLIC FATTY
   LIVER; NECROSIS-FACTOR-ALPHA; TISSUE GROWTH-FACTOR; ADIPOSE-TISSUE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; SIGNALING PATHWAYS;
   LIPID-METABOLISM
AB Hepatic insulin resistance is an important underlying cause of the metabolic syndrome that manifests itself in diseases such as diabetes type II, atherosclerosis or non-alcoholic fatty liver disease (NAFLD). In this paper, we summarize comprehensively the current state of knowledge pertaining to the molecular mechanisms that lead to insulin resistance in hepatocytes and sinusoidal liver cells.
   In hepatocytes, the insulin resistant state is brought about by at least one, but more likely by a combination, of the following pathological alterations: hyperglycaemia and hyperinsulinaemia, formation of advanced glycation end-products, increased free fatty acids and their metabolites, oxidative stress and altered profiles of adipocytokines. Insulin resistance in hepatocytes distorts directly glucose metabolism, especially the control over glucose output into the circulation and interferes with cell survival and proliferation, while hepatic fatty acid synthesis remains stimulated by compensatory hyperinsulinaemia, resulting in steatosis.
   Very few studies have addressed insulin resistance in sinusoidal liver cells. These cells are not simply bystanders and passive witnesses of the changes affecting the hepatocytes. They are target cells that will respond to the pathological alterations occurring in the insulin resistant state. They are also effector cells that may exacerbate insulin resistance in hepatocytes by increasing oxidative stress and by secreting cytokines such as TNF and IL-6. Moreover, activation of sinusoidal endothelial cells, Kupffer cells and stellate cells will lead to chemo-attraction of inflammatory cells. Finally, activation of stellate cells will set in motion a fibrogenic response that paves the way to cirrhosis. (c) 2007 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
C1 Catholic Univ Louvain, Fac Med, Gastrointestinal Lab, B-1200 Brussels, Belgium.
   Vrije Univ Brussel, Dept Cell Biol, Brussels, Belgium.
C3 Universite Catholique Louvain; Vrije Universiteit Brussel
RP Leclercq, IA (corresponding author), Catholic Univ Louvain, Fac Med, Gastrointestinal Lab, GAEN 53-79,Ave Mounier 53, B-1200 Brussels, Belgium.
EM isabelle.leclercq@uclouvain.be
RI Van Hul, Noemi/AAB-7985-2020; da Silva Morais, Alain/M-5574-2013
OI da Silva Morais, Alain/0000-0001-5057-0819; Van Hul,
   Noemi/0000-0003-1410-8808
CR AbdelWahab YHA, 1996, DIABETES, V45, P1489, DOI 10.2337/diabetes.45.11.1489
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Aleffi S, 2005, HEPATOLOGY, V42, P1339, DOI 10.1002/hep.20965
   Anderson PJ, 2001, INT J OBESITY, V25, P1782, DOI 10.1038/sj.ijo.0801837
   Arkan MC, 2005, NAT MED, V11, P191, DOI 10.1038/nm1185
   Baroni GS, 1998, HEPATOLOGY, V27, P720
   Basta G, 2006, J CLIN ENDOCR METAB, V91, P4628, DOI 10.1210/jc.2005-2559
   Bataller R, 2005, J CLIN INVEST, V115, P209, DOI 10.1172/JCI200524282
   BAYNES JW, 1991, DIABETES, V40, P405, DOI 10.2337/diabetes.40.4.405
   Biddinger SB, 2006, ANNU REV PHYSIOL, V68, P123, DOI 10.1146/annurev.physiol.68.040104.124723
   Blüher M, 2002, DEV CELL, V3, P25, DOI 10.1016/S1534-5807(02)00199-5
   Bruning JC, 1998, MOL CELL, V2, P559, DOI 10.1016/S1097-2765(00)80155-0
   Bugianesi E, 2005, HEPATOLOGY, V42, P987, DOI 10.1002/hep.20920
   Bugianesi E, 2005, J CLIN ENDOCR METAB, V90, P3498, DOI 10.1210/jc.2004-2240
   Cai DS, 2003, J BIOL CHEM, V278, P25323, DOI 10.1074/jbc.M212430200
   Cai DS, 2005, NAT MED, V11, P183, DOI 10.1038/nm1166
   Cao Q, 2004, J BIOL CHEM, V279, P4292, DOI 10.1074/jbc.M308351200
   Carrillo MC, 2001, LIFE SCI, V68, P1417, DOI 10.1016/S0024-3205(01)00936-5
   Choi SS, 2006, HEPATOLOGY, V44, P1267, DOI 10.1002/hep.21375
   De Meyts P, 2002, NAT REV DRUG DISCOV, V1, P769, DOI 10.1038/nrd917
   DeAngelis RA, 2005, HEPATOLOGY, V42, P1148, DOI 10.1002/hep.20879
   DEFRONZO RA, 1979, AM J PHYSIOL, V237, pE214
   Delerive P, 2000, J BIOL CHEM, V275, P36703, DOI 10.1074/jbc.M004045200
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Ding XK, 2005, AM J PATHOL, V166, P1655, DOI 10.1016/S0002-9440(10)62476-5
   Elinav E, 2006, J PATHOL, V209, P121, DOI 10.1002/path.1950
   Emanuelli B, 2001, J BIOL CHEM, V276, P47944, DOI 10.1074/jbc.M104602200
   Fehrenbach H, 2001, HEPATOLOGY, V34, P943, DOI 10.1053/jhep.2001.28788
   Flier JS, 2004, CELL, V116, P337, DOI 10.1016/S0092-8674(03)01081-X
   Foufelle F, 2002, BIOCHEM J, V366, P377, DOI 10.1042/BJ20020430
   Friedman SL, 2003, J HEPATOL, V38, pS38, DOI 10.1016/S0168-8278(02)00429-4
   Geerts A, 2001, SEMIN LIVER DIS, V21, P311, DOI 10.1055/s-2001-17550
   Gentilini A, 2000, J HEPATOL, V32, P227, DOI 10.1016/S0168-8278(00)80067-7
   George J, 2006, J GASTROEN HEPATOL, V21, pA315
   Goudriaan JR, 2003, J LIPID RES, V44, P2270, DOI 10.1194/jlr.M300143-JLR200
   Gual P, 2005, BIOCHIMIE, V87, P99, DOI 10.1016/j.biochi.2004.10.019
   Guerre-Millo M, 2004, DIABETES METAB, V30, P13, DOI 10.1016/S1262-3636(07)70084-8
   Hickman IJ, 2002, GUT, V51, P89, DOI 10.1136/gut.51.1.89
   Hofmann SM, 2002, DIABETES, V51, P2082, DOI 10.2337/diabetes.51.7.2082
   Horie Y, 2004, J CLIN INVEST, V113, P1774, DOI 10.1172/JCI200420513
   Horton JD, 2002, J CLIN INVEST, V109, P1125, DOI 10.1172/JCI200215593
   Horton JD, 2003, P NATL ACAD SCI USA, V100, P12027, DOI 10.1073/pnas.1534923100
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Ikejima K, 2002, GASTROENTEROLOGY, V122, P1399, DOI 10.1053/gast.2002.32995
   Ikejima K, 2001, HEPATOLOGY, V34, P288, DOI 10.1053/jhep.2001.26518
   Ip E, 2004, HEPATOLOGY, V39, P1286, DOI 10.1002/hep.20170
   Kadowaki T, 2006, J CLIN INVEST, V116, P1784, DOI 10.1172/JCI29126
   Kamada Y, 2003, GASTROENTEROLOGY, V125, P1796, DOI 10.1053/j.gastro.2003.08.029
   Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2548, DOI 10.1210/jc.2004-0395
   Kersten S, 1999, J CLIN INVEST, V103, P1489, DOI 10.1172/JCI6223
   Kim JK, 2000, J CLIN INVEST, V105, P1791, DOI 10.1172/JCI8305
   Kim JK, 2001, P NATL ACAD SCI USA, V98, P7522, DOI 10.1073/pnas.121164498
   Kim JK, 2001, J CLIN INVEST, V108, P437, DOI 10.1172/JCI11559
   Kim S, 2000, J NUTR, V130, p3110S
   Klover PJ, 2003, DIABETES, V52, P2784, DOI 10.2337/diabetes.52.11.2784
   Klover PJ, 2005, ENDOCRINOLOGY, V146, P3417, DOI 10.1210/en.2004-1468
   Lawler JF, 1998, J BIOL CHEM, V273, P5053, DOI 10.1074/jbc.273.9.5053
   Leclercq IA, 2003, GASTROENTEROLOGY, V124, P1451, DOI 10.1016/S0016-5085(03)00270-1
   Leclercq IA, 2002, J HEPATOL, V37, P206, DOI 10.1016/S0168-8278(02)00102-2
   Leclercq IA, 2000, J CLIN INVEST, V105, P1067, DOI 10.1172/JCI8814
   LECLERCQ IA, 2005, LAB INVEST, P143
   Leclercq IA, 2006, LAB INVEST, V86, P1161, DOI 10.1038/labinvest.3700474
   Lee Y, 2001, J BIOL CHEM, V276, P5629, DOI 10.1074/jbc.M008553200
   Maher JJ, 2001, SEMIN LIVER DIS, V21, P417, DOI 10.1055/s-2001-17555
   MARTIN KA, 1976, ADV CANCER RES, V25, P1429
   Michael MD, 2000, MOL CELL, V6, P87, DOI 10.1016/S1097-2765(00)00010-1
   Naito Makoto, 2004, Medical Electron Microscopy, V37, P16, DOI 10.1007/s00795-003-0228-x
   Nandi A, 2004, PHYSIOL REV, V84, P623, DOI 10.1152/physrev.00032.2003
   Nawano M, 1999, BIOCHEM BIOPH RES CO, V266, P252, DOI 10.1006/bbrc.1999.1797
   Oku A, 2001, AM J PHYSIOL-ENDOC M, V280, pE816, DOI 10.1152/ajpendo.2001.280.5.E816
   Ozawa K, 2005, DIABETES, V54, P657, DOI 10.2337/diabetes.54.3.657
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Paradis V, 2001, HEPATOLOGY, V34, P738, DOI 10.1053/jhep.2001.28055
   Paradis V, 2002, LAB INVEST, V82, P767, DOI 10.1097/01.LAB.0000017365.18894.D3
   Park P, 2006, J GASTROEN HEPATOL, V21, pS30, DOI 10.1111/j.1440-1746.2006.04580.x
   Parola M, 2001, J HEPATOL, V35, P297, DOI 10.1016/S0168-8278(01)00142-8
   POLI G, 1993, MOL ASPECTS MED, V14, P259, DOI 10.1016/0098-2997(93)90013-4
   Prentki M, 2006, J CLIN INVEST, V116, P1802, DOI 10.1172/JCI29103
   Previs SF, 2000, J BIOL CHEM, V275, P38990, DOI 10.1074/jbc.M006490200
   Ramasamy R, 2005, GLYCOBIOLOGY, V15, p16R, DOI 10.1093/glycob/cwi053
   Rask-Madsen C, 2007, NAT CLIN PRACT ENDOC, V3, P46, DOI 10.1038/ncpendmet0366
   REAVEN GM, 1995, PHYSIOL REV, V75, P473, DOI 10.1152/physrev.1995.75.3.473
   Reddy JK, 2006, AM J PHYSIOL-GASTR L, V290, pG852, DOI 10.1152/ajpgi.00521.2005
   Riboulet-Chavey A, 2006, DIABETES, V55, P1289, DOI 10.2337/db05-0857
   Roskams T, 2003, AM J PATHOL, V163, P1301, DOI 10.1016/S0002-9440(10)63489-X
   Ruan H, 2002, DIABETES, V51, P3176, DOI 10.2337/diabetes.51.11.3176
   Rui LY, 2001, J CLIN INVEST, V107, P181, DOI 10.1172/JCI10934
   Rui LY, 2002, J BIOL CHEM, V277, P42394, DOI 10.1074/jbc.C200444200
   Samuel VT, 2004, J BIOL CHEM, V279, P32345, DOI 10.1074/jbc.M313478200
   SAMUEL VT, 2004, FATTY LIVER DIS, P38
   Sandu O, 2005, DIABETES, V54, P2314, DOI 10.2337/diabetes.54.8.2314
   Sanyal AJ, 2001, GASTROENTEROLOGY, V120, P1183, DOI 10.1053/gast.2001.23256
   Saxena NK, 2004, FASEB J, V18, P1612, DOI 10.1096/fj.04-1847fje
   Saxena NK, 2002, HEPATOLOGY, V35, P762, DOI 10.1053/jhep.2002.32029
   Schalkwijk CG, 2005, CLIN SCI, V109, P143, DOI 10.1042/CS20050025
   Schattenberg JM, 2006, HEPATOLOGY, V43, P163, DOI 10.1002/hep.20999
   Schattenberg JRM, 2005, J BIOL CHEM, V280, P9887, DOI 10.1074/jbc.M410310200
   Senn JJ, 2003, J BIOL CHEM, V278, P13740, DOI 10.1074/jbc.M210689200
   Shen JH, 2005, LIFE SCI, V77, P1502, DOI 10.1016/j.lfs.2005.04.004
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   SHULMAN GI, 2000, J CLIN INVEST, V106, P171, DOI [DOI 10.1172/JCI10583, 10.1172/jci10583]
   Smedsrod B, 1997, BIOCHEM J, V322, P567, DOI 10.1042/bj3220567
   SODA R, 1983, EXP CELL RES, V145, P389, DOI 10.1016/0014-4827(83)90017-4
   STARZL TE, 1976, METABOLISM, V25, P1429, DOI 10.1016/S0026-0495(76)80158-8
   Svegliati-Baroni G, 1999, HEPATOLOGY, V29, P1743, DOI 10.1002/hep.510290632
   Taniguchi CM, 2006, NAT REV MOL CELL BIO, V7, P85, DOI 10.1038/nrm1837
   Taniguchi CM, 2005, J CLIN INVEST, V115, P718, DOI 10.1172/JCI200523187
   Teufelhofer O, 2005, CARCINOGENESIS, V26, P319, DOI 10.1093/carcin/bgh320
   Thakur V, 2006, AM J PHYSIOL-GASTR L, V290, pG998, DOI 10.1152/ajpgi.00553.2005
   Tsukamoto H, 2006, HEPATOLOGY, V44, p227A
   Ueki K, 2004, P NATL ACAD SCI USA, V101, P10422, DOI 10.1073/pnas.0402511101
   Uysal KT, 1997, NATURE, V389, P610, DOI 10.1038/39335
   Vinciguerra Manlio, 2006, Archives of Physiology and Biochemistry, V112, P89, DOI 10.1080/13813450600711359
   Voshol PJ, 2003, ENDOCRINOLOGY, V144, P3456, DOI 10.1210/en.2002-0036
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   White MF, 2002, AM J PHYSIOL-ENDOC M, V283, pE413, DOI 10.1152/ajpendo.00514.2001
   WISSE E, 1970, J ULTRA MOL STRUCT R, V31, P125, DOI 10.1016/S0022-5320(70)90150-4
   Yamauchi T, 2002, NAT MED, V8, P1288, DOI 10.1038/nm788
   Yang SQ, 2004, HEPATOLOGY, V39, P403, DOI 10.1002/hep.20082
   Yin MJ, 1998, NATURE, V396, P77, DOI 10.1038/23948
   Yki-Järvinen H, 2005, ANN MED, V37, P347, DOI 10.1080/07853890510037383
   Yu CL, 2002, J BIOL CHEM, V277, P50230, DOI 10.1074/jbc.M200958200
   Yuan MS, 2001, SCIENCE, V293, P1673, DOI 10.1126/science.1061620
NR 124
TC 271
Z9 313
U1 2
U2 30
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0168-8278
EI 1600-0641
J9 J HEPATOL
JI J. Hepatol.
PD JUL
PY 2007
VL 47
IS 1
BP 142
EP 156
DI 10.1016/j.jhep.2007.04.002
PG 15
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 185JG
UT WOS:000247706700021
PM 17512085
OA Bronze
DA 2025-06-11
ER

PT J
AU Lee, WS
   Ham, W
   Kim, J
AF Lee, Wang-Soo
   Ham, Woojin
   Kim, Jaetaek
TI Roles of NAD(P)H:quinone Oxidoreductase 1 in Diverse Diseases
SO LIFE-BASEL
LA English
DT Article
DE NAD(P)H; quinone oxidoreductase 1; oxidative stress; human diseases
ID MEMBRANE REDOX SYSTEM; INDUCED DNA-DAMAGE; HIGH-FAT DIET; DT-DIAPHORASE;
   OXIDATIVE STRESS; NAD(P)H-QUINONE OXIDOREDUCTASE; QUINONE
   OXIDOREDUCTASE; BETA-LAPACHONE; PROTEASOMAL DEGRADATION;
   CRYSTAL-STRUCTURE
AB NAD(P)H:quinone oxidoreductase (NQO) is an antioxidant flavoprotein that catalyzes the reduction of highly reactive quinone metabolites by employing NAD(P)H as an electron donor. There are two NQO enzymes-NQO1 and NQO2-in mammalian systems. In particular, NQO1 exerts many biological activities, including antioxidant activities, anti-inflammatory effects, and interactions with tumor suppressors. Moreover, several recent studies have revealed the promising roles of NQO1 in protecting against cardiovascular damage and related diseases, such as dyslipidemia, atherosclerosis, insulin resistance, and metabolic syndrome. In this review, we discuss recent developments in the molecular regulation and biochemical properties of NQO1, and describe the potential beneficial roles of NQO1 in diseases associated with oxidative stress.
C1 [Lee, Wang-Soo] Chung Ang Univ, Div Cardiol, Dept Internal Med, Coll Med, Seoul 06974, South Korea.
   [Ham, Woojin; Kim, Jaetaek] Chung Ang Univ, Div Endocrinol & Metab, Dept Internal Med, Coll Med, Seoul 06974, South Korea.
C3 Chung Ang University; Chung Ang University Hospital; Chung Ang
   University; Chung Ang University Hospital
RP Lee, WS (corresponding author), Chung Ang Univ, Div Cardiol, Dept Internal Med, Coll Med, Seoul 06974, South Korea.; Kim, J (corresponding author), Chung Ang Univ, Div Endocrinol & Metab, Dept Internal Med, Coll Med, Seoul 06974, South Korea.
EM wslee1227@cau.ac.kr; dglyue5@cau.ac.kr; jtkim@cau.ac.kr
RI Lee, Wang-Soo/AAS-1477-2021
OI Lee, Wang-Soo/0000-0002-8264-0866
FU Chung-Ang University Research Scholarship Grants 2020; Basic Science
   Research Program through the National Research Foundation of Korea
   [2020R1A2C1009647]
FX This study was supported by Chung-Ang University Research Scholarship
   Grants 2020 to W.H., and by the Basic Science Research Program through
   the National Research Foundation of Korea to W.-S.L. (2020R1A2C1009647).
CR Adamovich Y, 2013, MOL CELL BIOL, V33, P2603, DOI 10.1128/MCB.01672-12
   Alard A, 2010, MOL CELL BIOL, V30, P1097, DOI 10.1128/MCB.00868-09
   Anwar A, 2003, J BIOL CHEM, V278, P10368, DOI 10.1074/jbc.M211981200
   Asher G, 2005, MOL CELL, V17, P645, DOI 10.1016/j.molcel.2005.01.020
   Asher G, 2005, GENE DEV, V19, P316, DOI 10.1101/gad.319905
   Asher G, 2001, P NATL ACAD SCI USA, V98, P1188, DOI 10.1073/pnas.021558898
   Asher G, 2006, BIOCHEMISTRY-US, V45, P6372, DOI 10.1021/bi0600087
   ATALLAH AS, 1988, BIOCHEM PHARMACOL, V37, P2451, DOI 10.1016/0006-2952(88)90373-5
   Awadallah NS, 2008, APPL IMMUNOHISTO M M, V16, P24, DOI 10.1097/pai.0b013e31802e91d0
   Bailey SM, 1998, BIOCHEM PHARMACOL, V56, P613, DOI 10.1016/S0006-2952(97)00661-8
   Bair JS, 2010, J AM CHEM SOC, V132, P5469, DOI 10.1021/ja100610m
   BEALL HD, 1994, CANCER RES, V54, P3196
   Bey EA, 2007, P NATL ACAD SCI USA, V104, P11832, DOI 10.1073/pnas.0702176104
   Bey EA, 2013, MOL CANCER THER, V12, P2110, DOI 10.1158/1535-7163.MCT-12-0962
   Beyer RE, 1996, P NATL ACAD SCI USA, V93, P2528, DOI 10.1073/pnas.93.6.2528
   Bianchet MA, 2004, METHOD ENZYMOL, V382, P144
   BINDOLI A, 1985, BIOCHEM INT, V10, P753
   BOOTHMAN DA, 1993, P NATL ACAD SCI USA, V90, P7200, DOI 10.1073/pnas.90.15.7200
   CADENAS E, 1995, BIOCHEM PHARMACOL, V49, P127, DOI 10.1016/S0006-2952(94)00333-5
   Cadenas S, 2018, FREE RADICAL BIO MED, V117, P76, DOI 10.1016/j.freeradbiomed.2018.01.024
   Cao ZX, 2004, BIOCHEM BIOPH RES CO, V317, P1080, DOI 10.1016/j.bbrc.2004.03.156
   Cassagnes LE, 2015, FREE RADICAL BIO MED, V89, P126, DOI 10.1016/j.freeradbiomed.2015.07.150
   Castello A, 2012, CELL, V149, P1393, DOI 10.1016/j.cell.2012.04.031
   Cavalieri E, 2006, BBA-REV CANCER, V1766, P63, DOI 10.1016/j.bbcan.2006.03.001
   Chakrabarti G, 2015, SCI REP-UK, V5, DOI 10.1038/srep17066
   Chandrasena REP, 2008, CHEM RES TOXICOL, V21, P1324, DOI 10.1021/tx8000797
   Chang P, 2005, NAT CELL BIOL, V7, P1133, DOI 10.1038/ncb1322
   Chartoumpekis DV, 2018, AM J PHYSIOL-ENDOC M, V315, pE180, DOI 10.1152/ajpendo.00311.2017
   Chartoumpekis DV, 2013, CURR DIABETES REV, V9, P137, DOI 10.2174/1573399811309020005
   CHEN S, 1994, PROTEIN SCI, V3, P51
   Chen SA, 1999, MOL PHARMACOL, V56, P272, DOI 10.1124/mol.56.2.272
   Chen XL, 2003, J BIOL CHEM, V278, P703, DOI 10.1074/jbc.M203161200
   CHESIS PL, 1984, P NATL ACAD SCI-BIOL, V81, P1696, DOI 10.1073/pnas.81.6.1696
   Chhetri J, 2018, CURR ALZHEIMER RES, V15, P56, DOI 10.2174/1567205014666170203095802
   Choudry GA, 2001, BRIT J CANCER, V85, P1137, DOI 10.1054/bjoc.2001.2056
   Covarrubias AJ, 2021, NAT REV MOL CELL BIO, V22, P119, DOI 10.1038/s41580-020-00313-x
   DANIELSON L, 1962, NATURE, V194, P155, DOI 10.1038/194155a0
   De Cabo R, 2004, EXP GERONTOL, V39, P297, DOI 10.1016/j.exger.2003.12.003
   Dehn DL, 2005, J PHARMACOL EXP THER, V313, P771, DOI 10.1124/jpet.104.081380
   Dehn DL, 2004, CLIN CANCER RES, V10, P3147, DOI 10.1158/1078-0432.CCR-03-0411
   DELONG MJ, 1986, P NATL ACAD SCI USA, V83, P787
   Di Francesco A, 2016, FREE RADICAL BIO MED, V99, P225, DOI 10.1016/j.freeradbiomed.2016.08.005
   Diaz-Ruiz A, 2019, J GERONTOL A-BIOL, V74, P155, DOI 10.1093/gerona/gly112
   Diaz-Ruiz A, 2018, AGING CELL, V17, DOI 10.1111/acel.12767
   Digby EM, 2020, CHEM-EUR J, V26, P2713, DOI 10.1002/chem.201904607
   Dinkova-Kostova AT, 2010, ARCH BIOCHEM BIOPHYS, V501, P116, DOI 10.1016/j.abb.2010.03.019
   Dovinova I, 2020, PHYSIOL RES, V69, pS541, DOI 10.33549/physiolres.934612
   ERNSTER L, 1958, ANNU REV PHYSIOL, V20, P13, DOI 10.1146/annurev.ph.20.030158.000305
   ERNSTER L, 1987, CHEM SCRIPTA, V27A, P1
   Ernster L., 1967, Methods Enzymol, V10, P309
   Faig M, 2000, P NATL ACAD SCI USA, V97, P3177, DOI 10.1073/pnas.050585797
   Foster CE, 1999, BIOCHEMISTRY-US, V38, P9881, DOI 10.1021/bi990799v
   Gaedigk A, 1998, PHARMACOGENETICS, V8, P305, DOI 10.1097/00008571-199808000-00004
   Gaikwad A, 2001, J BIOL CHEM, V276, P22559, DOI 10.1074/jbc.M101053200
   Garate M, 2008, EMBO REP, V9, P576, DOI 10.1038/embor.2008.48
   García N, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/5853238
   Guo WC, 2005, CANCER RES, V65, P10006, DOI 10.1158/0008-5472.CAN-05-2029
   Han SJ, 2009, MOL GENET METAB, V97, P85, DOI 10.1016/j.ymgme.2009.01.012
   Herrera A, 2017, ACS CHEM NEUROSCI, V8, P702, DOI 10.1021/acschemneuro.7b00034
   HOSODA S, 1974, J BIOL CHEM, V249, P6416
   Hu LT, 1996, CANCER RES, V56, P5253
   Huang BH, 2010, ORG LETT, V12, P1384, DOI 10.1021/ol1002626
   Huang NY, 2018, ACTA BIOCH BIOPH SIN, V50, P733, DOI 10.1093/abbs/gmy063
   Hur KY, 2010, ATHEROSCLEROSIS, V211, P69, DOI 10.1016/j.atherosclerosis.2010.01.035
   Hwang JH, 2009, DIABETES, V58, P965, DOI 10.2337/db08-1183
   Hyun DH, 2006, P NATL ACAD SCI USA, V103, P19908, DOI 10.1073/pnas.0608008103
   Hyun DH, 2006, AGEING RES REV, V5, P209, DOI 10.1016/j.arr.2006.03.005
   Imai S, 2016, NPJ AGING MECH DIS, V2, DOI 10.1038/npjamd.2016.17
   Isbir CS, 2008, CELL BIOCHEM FUNCT, V26, P534, DOI 10.1002/cbf.1456
   Iskander K, 2005, CANCER RES, V65, P2054, DOI 10.1158/0008-5472.CAN-04-3157
   IYANAGI T, 1970, BIOCHIM BIOPHYS ACTA, V216, P282, DOI 10.1016/0005-2728(70)90220-3
   JAISWAL AK, 1994, J BIOL CHEM, V269, P14502
   JAISWAL AK, 1990, BIOCHEMISTRY-US, V29, P1899, DOI 10.1021/bi00459a034
   Kang HJ, 2018, FREE RADICAL BIO MED, V126, P358, DOI 10.1016/j.freeradbiomed.2018.08.009
   Kelsey KT, 1997, BRIT J CANCER, V76, P852, DOI 10.1038/bjc.1997.474
   Kiffmeyer WR, 2004, CANCER-AM CANCER SOC, V100, P411, DOI 10.1002/cncr.11913
   Kim HJ, 2014, CELL DEATH DIS, V5, DOI 10.1038/cddis.2014.255
   Kim HJ, 2019, AGING CELL, V18, DOI 10.1111/acel.13016
   Kim SY, 2009, CIRC RES, V104, P842, DOI 10.1161/CIRCRESAHA.108.189837
   Kim YH, 2011, CARDIOVASC RES, V91, P519, DOI 10.1093/cvr/cvr110
   KOHAR I, 1995, FREE RADICAL BIO MED, V19, P197, DOI 10.1016/0891-5849(95)00010-U
   Kristiansen OP, 1999, HUM MUTAT, V14, P67, DOI 10.1002/(SICI)1098-1004(1999)14:1<67::AID-HUMU8>3.0.CO;2-5
   Lee JS, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047122
   Lee SO, 2007, CARDIOVASC RES, V76, P331, DOI 10.1016/j.cardiores.2007.06.030
   Li BW, 2017, J MATER CHEM B, V5, P2635, DOI 10.1039/c7tb00266a
   Li LS, 2011, CLIN CANCER RES, V17, P275, DOI 10.1158/1078-0432.CCR-10-1983
   LI RB, 1995, P NATL ACAD SCI USA, V92, P8846, DOI 10.1073/pnas.92.19.8846
   Li WP, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9010069
   LIEBLER DC, 1993, CRIT REV TOXICOL, V23, P147, DOI 10.3109/10408449309117115
   Lienhart WD, 2017, FEBS J, V284, P1233, DOI 10.1111/febs.14051
   LIND C, 1982, ARCH BIOCHEM BIOPHYS, V216, P178, DOI 10.1016/0003-9861(82)90202-8
   LIND C, 1990, METHOD ENZYMOL, V186, P287
   Liu PL, 2015, CHEM COMMUN, V51, P9567, DOI 10.1039/c5cc02149a
   Ludtmann MHR, 2014, BIOCHEM J, V457, P415, DOI 10.1042/BJ20130863
   Luo JR, 2016, INT J NEUROSCI, V126, P199, DOI 10.3109/00207454.2015.1004573
   Julia LM, 2018, BIOMED PHARMACOTHER, V108, P1553, DOI 10.1016/j.biopha.2018.09.159
   Martens CR, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-03421-7
   Martin NJ, 2009, MUTAT RES-GEN TOX EN, V674, P93, DOI 10.1016/j.mrgentox.2008.09.009
   Martínez-Limón A, 2016, P NATL ACAD SCI USA, V113, P12156, DOI 10.1073/pnas.1611994113
   Meakin PJ, 2014, MOL CELL BIOL, V34, P3305, DOI [10.1128/MCB.00677-14, 10.1128/MCB.00677-1]
   Milkovic L, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8091001
   Montano MM, 2005, FRONT BIOSCI-LANDMRK, V10, P1440, DOI 10.2741/1630
   Montano MM, 1998, J BIOL CHEM, V273, P25443, DOI 10.1074/jbc.273.39.25443
   Nebert DW, 2002, GENET MED, V4, P62, DOI 10.1097/00125817-200203000-00003
   Niemann B, 2017, J AM COLL CARDIOL, V70, P230, DOI 10.1016/j.jacc.2017.05.043
   Nioi P, 2004, MUTAT RES-FUND MOL M, V555, P149, DOI 10.1016/j.mrfmmm.2004.05.023
   North BJ, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000784
   Oh ET, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms13593
   Oh GS, 2016, BIOMED RES INT, V2016, DOI 10.1155/2016/4048390
   Palming J, 2007, J CLIN ENDOCR METAB, V92, P2346, DOI 10.1210/jc.2006-2476
   Pan SS, 2002, PHARMACOGENETICS, V12, P479, DOI 10.1097/00008571-200208000-00009
   Pardo M, 2020, CHEM RES TOXICOL, V33, P1110, DOI 10.1021/acs.chemrestox.0c00007
   Pey AL, 2014, BBA-MOL BASIS DIS, V1842, P2163, DOI 10.1016/j.bbadis.2014.08.011
   Pink JJ, 2000, J BIOL CHEM, V275, P5416, DOI 10.1074/jbc.275.8.5416
   Pink JJ, 2000, EXP CELL RES, V255, P144, DOI 10.1006/excr.1999.4790
   POWIS G, 1987, PHARMACOL THERAPEUT, V35, P57, DOI 10.1016/0163-7258(87)90105-7
   PROCHASKA HJ, 1987, J BIOL CHEM, V262, P1931
   Raina AK, 1999, REDOX REP, V4, P23, DOI 10.1179/135100099101534701
   Reuter S, 2010, FREE RADICAL BIO MED, V49, P1603, DOI 10.1016/j.freeradbiomed.2010.09.006
   Rokah OH, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011401
   ROSS D, 1993, CANCER METAST REV, V12, P83, DOI 10.1007/BF00689803
   Ross D, 2004, DRUG METAB REV, V36, P639, DOI 10.1081/DMR-200033465
   Ross D, 2000, CHEM-BIOL INTERACT, V129, P77, DOI 10.1016/S0009-2797(00)00199-X
   Ross D, 1996, BRIT J CANCER, V74, pS1
   Ross D, 2021, REDOX BIOL, V41, DOI 10.1016/j.redox.2021.101950
   Ross David, 2018, Current Opinion in Toxicology, V7, P67, DOI 10.1016/j.cotox.2017.10.005
   Ross D, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00595
   SantaCruz KS, 2004, NEUROBIOL AGING, V25, P63, DOI 10.1016/S0197-4580(03)00117-9
   Saxena A, 2002, HUM MOL GENET, V11, P2319, DOI 10.1093/hmg/11.19.2319
   Sekiguchi M, 2020, NPJ PRECIS ONCOL, V4, DOI 10.1038/s41698-020-0125-y
   Sharma K, 2013, ORG LETT, V15, P2636, DOI 10.1021/ol400884v
   Sharma RS, 2018, CELL MOL GASTROENTER, V5, P367, DOI 10.1016/j.jcmgh.2017.11.016
   Shin WS, 2016, BIOCONJUGATE CHEM, V27, P1419, DOI 10.1021/acs.bioconjchem.6b00184
   Shyu HY, 2010, CLIN CHIM ACTA, V411, P840, DOI 10.1016/j.cca.2010.02.071
   Siegel D, 1997, MOL PHARMACOL, V52, P300, DOI 10.1124/mol.52.2.300
   SIEGEL D, 1990, CANCER RES, V50, P7483
   Siegel D, 2004, MOL PHARMACOL, V65, P1238, DOI 10.1124/mol.65.5.1238
   SIEGEL D, 1990, CANCER RES, V50, P7293
   Siegel D, 2021, REDOX BIOL, V39, DOI 10.1016/j.redox.2020.101840
   Siegel D, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0190717
   Siegel D, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0044861
   Sieger D, 2000, FREE RADICAL BIO MED, V29, P246, DOI 10.1016/S0891-5849(00)00310-5
   Skelly JV, 1999, J MED CHEM, V42, P4325, DOI 10.1021/jm991060m
   Starcher CL, 2020, FRONT ONCOL, V10, DOI 10.3389/fonc.2020.01575
   Sun XL, 2020, DIABET METAB SYND OB, V13, P4281, DOI 10.2147/DMSO.S274315
   Sverdlov AL, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.115.002555
   Tada M, 2005, J HEPATOL, V42, P511, DOI 10.1016/j.jhep.2004.11.024
   TEDESCHI G, 1995, J BIOL CHEM, V270, P1198, DOI 10.1074/jbc.270.3.1198
   THOR H, 1982, J BIOL CHEM, V257, P2419
   Tönnies E, 2017, J ALZHEIMERS DIS, V57, P1105, DOI 10.3233/JAD-161088
   Traver RD, 1997, BRIT J CANCER, V75, P69, DOI 10.1038/bjc.1997.11
   Uruno A, 2013, MOL CELL BIOL, V33, P2996, DOI 10.1128/MCB.00225-13
   Vanni A, 1998, MUTAT RES-FUND MOL M, V401, P55, DOI 10.1016/S0027-5107(97)00273-X
   Varghese JF, 2018, CURR CARDIOL REV, V14, P4, DOI 10.2174/1573403X13666171009112250
   Vasileva LV, 2020, PHARMACOL RES, V156, DOI 10.1016/j.phrs.2020.104760
   Vatolin S, 2019, NPJ AGING MECH DIS, V5, DOI 10.1038/s41514-018-0032-4
   Verdin E, 2015, SCIENCE, V350, P1208, DOI 10.1126/science.aac4854
   Volpato M, 2007, MOL CANCER THER, V6, P3122, DOI 10.1158/1535-7163.MCT-07-0519
   Vomund S, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18122772
   Wang GY, 2006, BIOCHEM BIOPH RES CO, V341, P310, DOI 10.1016/j.bbrc.2005.12.195
   Wang MX, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.649785
   Wang YX, 2000, NEUROBIOL AGING, V21, P525, DOI 10.1016/S0197-4580(00)00114-7
   WEFERS H, 1983, ARCH BIOCHEM BIOPHYS, V224, P568, DOI 10.1016/0003-9861(83)90244-8
   Whaley-Connell A, 2011, REV CARDIOVASC MED, V12, P21, DOI 10.3909/ricm0555
   Winski SL, 2002, CANCER RES, V62, P1420
   Wu YL, 2013, FREE RADICAL BIO MED, V65, P632, DOI 10.1016/j.freeradbiomed.2013.07.037
   Xu ST, 2017, EUR J MED CHEM, V132, P310, DOI 10.1016/j.ejmech.2017.03.055
   Yagishita Y, 2019, J ENDOCRINOL, V240, P403, DOI 10.1530/JOE-18-0355
   Yao X, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0139416
   Yates A, 2016, NUCLEIC ACIDS RES, V44, pD710, DOI 10.1093/nar/gkv1157
   Zhang X, 2018, ORG LETT, V20, P3635, DOI 10.1021/acs.orglett.8b01409
   Zhang ZG, 2015, REV ENDOCR METAB DIS, V16, P35, DOI 10.1007/s11154-014-9305-9
   Zhao QJ, 1997, P NATL ACAD SCI USA, V94, P1669, DOI 10.1073/pnas.94.5.1669
   Zhu H, 2007, CARDIOVASC TOXICOL, V7, P202, DOI 10.1007/s12012-007-9001-z
   Zhu H, 2012, CARDIOVASC TOXICOL, V12, P39, DOI 10.1007/s12012-011-9136-9
NR 175
TC 32
Z9 33
U1 1
U2 18
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD DEC
PY 2021
VL 11
IS 12
AR 1301
DI 10.3390/life11121301
PG 20
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA YA3SI
UT WOS:000738256800001
PM 34947831
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mohamed, AI
   Erukainure, OL
   Salau, VF
   Islam, MS
AF Mohamed, Almahi I.
   Erukainure, Ochuko L.
   Salau, Veronica F.
   Islam, Md Shahidul
TI Impact of coffee and its bioactive compounds on the risks of type 2
   diabetes and its complications: A comprehensive review
SO DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
LA English
DT Review
DE Coffee; Diabetes; Hyperglycemia; Obesity; Oxidative stress
ID DNA STRAND BREAKS; OXIDATIVE STRESS; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; CHLOROGENIC ACID; ENDOTHELIAL DYSFUNCTION;
   ANTIOXIDANT ACTIVITY; INSULIN-RESISTANCE; CLIMATE-CHANGE; HEART-FAILURE
AB Background: Coffee beans have a long history of use as traditional medicine by various indigenous people. Recent focus has been given to the health benefits of coffee beans and its bioactive compounds. Research on the bioactivities, applications, and effects of processing methods on coffee beans' phytochemical composition and activities has been conducted extensively. The current review attempts to provide an update on the biological effects of coffee on type 2 diabetes (T2D) and its comorbidities. Methods: Comprehensive literature search was carried out on peer-reviewed published data on biological activities of coffee on in vitro, in vivo and epidemiological research results published from January 2015 to December 2022, using online databases such as PubMed, Google Scholar and ScienceDirect for our searches. Results: The main findings were: firstly, coffee may contribute to the prevention of oxidative stress and T2Drelated illnesses such as cardiovascular disease, retinopathy, obesity, and metabolic syndrome; secondly, consuming up to 400 mg/day (1-4 cups per day) of coffee is associated with lower risks of T2D; thirdly, caffeine consumed between 0.5 and 4 h before a meal may inhibit acute metabolic rate; and finally, both caffeinated and decaffeinated coffee are associated with reducing the risks of T2D. Conclusion: Available evidence indicates that long-term consumption of coffee is associated with decreased risk of T2D and its complications as well as decreased body weight. This has been attributed to the consumption of coffee with the abundance of bioactive chemicals.
C1 [Mohamed, Almahi I.; Erukainure, Ochuko L.; Salau, Veronica F.; Islam, Md Shahidul] Univ KwaZulu Natal, Dept Biochem, Westville Campus, ZA-4000 Durban, South Africa.
   [Erukainure, Ochuko L.] Univ KwaZulu Natal, Dept Microbiol, Westville Campus, ZA-4000 Durban, South Africa.
   [Salau, Veronica F.] Univ Free State, Dept Pharmacol, ZA-9300 Bloemfontein, South Africa.
C3 University of Kwazulu Natal; University of Kwazulu Natal; University of
   the Free State
RP Islam, MS (corresponding author), Univ KwaZulu Natal, Dept Biochem, Westville Campus, ZA-4000 Durban, South Africa.
EM islamd@ukzn.ac.za
RI Islam, Shahidul/N-5897-2013; Erukainure, Ochuko/G-9888-2014; Salau,
   Veronica/GQZ-7764-2022
OI Erukainure, Ochuko/0000-0003-0489-338X
FU National Research Foundation (NRF), Pretoria; University of
   KwaZulu-Natal, Durban, South Africa
FX This work was supported by a Incentive Grant for Rated Researchers from
   the National Research Foundation (NRF), Pretoria; and Research Rewards
   from the University of KwaZulu-Natal, Durban, South Africa.
CR Abidah RS, 2017, Heal Notions, V1, P330
   Adegbola P, 2017, AM J CARDIOVASC DIS, V7, P19
   Adepoju A. F., 2017, IOSR-JAVS, V10, P57, DOI [10.9790/2380-1007035762, DOI 10.9790/2380-1007035762]
   Ahangarpour A, 2019, DIABETES METAB SYND, V13, P854, DOI 10.1016/j.dsx.2018.11.051
   Ahmad JB, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/6679185
   Akpertey A, 2022, PLANT BREEDING, V141, P286, DOI 10.1111/pbr.13005
   Al Reef T, 2018, IMMUNOBIOLOGY, V223, P818, DOI 10.1016/j.imbio.2018.08.011
   Alemu Kumlachew, 2016, Archives of Phytopathology and Plant Protection, V49, P421, DOI 10.1080/03235408.2016.1228736
   Alongi M, 2021, FOOD CHEM, V342, DOI 10.1016/j.foodchem.2020.128289
   Alongi M, 2018, FOOD RES INT, V111, P480, DOI 10.1016/j.foodres.2018.05.061
   Alsunni AA, 2015, INT J HEALTH SCI-IJH, V9, P468, DOI 10.12816/0031237
   Aluka P, 2016, The diversity of green bean biochemical compounds in robusta coffee (Coffea canephora Pierre ex A. Froehner) as evaluated by near infrared spectroscopy
   Alvim RO, 2015, AN ACAD BRAS CIENC, V87, P351, DOI 10.1590/0001-3765201520140225
   Angeloni S, 2021, MOLECULES, V26, DOI 10.3390/molecules26133856
   Anisa A, 2017, INT FOOD RES J, V24, P2285
   Aprioku JS, 2022, DRUG CHEM TOXICOL, V45, P1012, DOI 10.1080/01480545.2020.1802479
   Arauz J, 2017, NUTR RES, V40, P65, DOI 10.1016/j.nutres.2017.03.008
   Asbaghi O, 2021, COMPLEMENT THER CLIN, V43, DOI 10.1016/j.ctcp.2021.101349
   Asgary S, 2018, J AM COLL NUTR, V37, P429, DOI 10.1080/07315724.2017.1410867
   Ashihara H, 2017, PROG CHEM ORG NAT PR, V105, P1, DOI 10.1007/978-3-319-49712-9_1
   Babova O, 2016, PHYTOCHEMISTRY, V123, P33, DOI 10.1016/j.phytochem.2016.01.016
   Bacon CM, 2017, WORLD DEV, V93, P136, DOI 10.1016/j.worlddev.2016.12.025
   Bae IK, 2015, FOOD CHEM, V172, P469, DOI 10.1016/j.foodchem.2014.09.050
   Bakuradze T, 2015, EUR J NUTR, V54, P149, DOI 10.1007/s00394-014-0696-x
   Bakuradze T, 2016, MOL NUTR FOOD RES, V60, P682, DOI 10.1002/mnfr.201500668
   Balaji R, 2019, Drug Invent Today, V12
   Balakumar P, 2016, PHARMACOL RES, V113, P600, DOI 10.1016/j.phrs.2016.09.040
   Bao LP, 2018, INT IMMUNOPHARMACOL, V54, P245, DOI 10.1016/j.intimp.2017.11.021
   Barbosa JB, 2016, CIENC SAUDE COLETIVA, V21, P1123, DOI 10.1590/1413-81232015214.10472015
   Barrea L, 2023, CRIT REV FOOD SCI, V63, P1238, DOI 10.1080/10408398.2021.1963207
   Batiha GE, 2020, ANTIBIOTICS-BASEL, V9, DOI 10.3390/antibiotics9060353
   Bazal P, 2021, EUR J PREV CARDIOL, V28, P648, DOI 10.1177/2047487320909065
   Belachew K, 2020, TROP PLANT PATHOL, V45, P511, DOI 10.1007/s40858-020-00383-4
   Belandria V, 2016, INNOV FOOD SCI EMERG, V37, P145, DOI 10.1016/j.ifset.2016.07.022
   Bernea EG, 2018, P ROMANIAN ACAD S B, V20, P121
   Bhatwadekar AD, 2021, GENES-BASEL, V12, DOI 10.3390/genes12081200
   Bodis KB, 2021, Lipid and energy metabolism of white adipose tissue in insulin-resistant humans
   Boerdery A, 2021, Farmers Wkly, V2021, P44
   Annette B, 2017, BBA-MOL BASIS DIS, V1863, P1026, DOI 10.1016/j.bbadis.2017.01.016
   Bonzemo SB, 2022, J Agric Environ Sci, V11, P1
   Bray GA, 2017, OBES REV, V18, P715, DOI 10.1111/obr.12551
   Bunn C, 2015, CLIMATIC CHANGE, V129, P89, DOI 10.1007/s10584-014-1306-x
   Burgos-Morón E, 2019, J CLIN MED, V8, DOI 10.3390/jcm8091385
   Cahyono ED, 2020, LAND-BASEL, V9, DOI 10.3390/land9100363
   Cainzos-Achirica M, 2018, CURR CARDIOVASC RISK, V12, DOI 10.1007/s12170-018-0567-8
   Camargo M.A.F., 2019, Open Access Libr. J, V6, P1, DOI [10.4236/oalib, DOI 10.4236/OALIB.1105265, 10.4236/oalib.1105265]
   Cantley J, 2015, BMC BIOL, V13, DOI 10.1186/s12915-015-0140-6
   Caporaso N, 2018, J FOOD ENG, V227, P18, DOI 10.1016/j.jfoodeng.2018.01.009
   Caracostea L.-M., 2021, Eur. J. Nat. Sci. Med, V4, P67, DOI [10.26417/425qba31z, DOI 10.26417/425QBA31Z]
   Cardin R, 2013, DIGEST LIVER DIS, V45, P499, DOI 10.1016/j.dld.2012.10.021
   Carlström M, 2018, NUTR REV, V76, P395, DOI 10.1093/nutrit/nuy014
   Casal S, 2017, CURR MED CHEM, V24, P376, DOI 10.2174/0929867323666161003123717
   Castaldo L, 2021, FOODS, V10, DOI 10.3390/foods10081837
   Castillo NET, 2020, SCI TOTAL ENVIRON, V738, DOI 10.1016/j.scitotenv.2020.140225
   Cavalcanti MH, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0262270
   Chen SJ, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10071092
   Chen XM, 2018, ENDOCRINE, V60, P83, DOI 10.1007/s12020-018-1525-4
   Cheneke B, 2019, Adapt Gener Agric Technol, V26, P286
   Chieng D, 2022, TRENDS CARDIOVAS MED, V32, P399, DOI 10.1016/j.tcm.2021.08.004
   Choi S, 2018, NUTRIENTS, V10, DOI 10.3390/nu10030363
   Clifford MN, 2020, COMPR REV FOOD SCI F, V19, P1299, DOI 10.1111/1541-4337.12518
   Conti F, 2022, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.824885
   Cortes A, 2016, Molecular aspects. Neuropathol. Drug addict. Subst. Misuse, P741
   Costabile A, 2018, J FUNCT FOODS, V45, P409, DOI 10.1016/j.jff.2018.04.011
   Cui WQ, 2020, WORLD J GASTRO ONCOL, V12, DOI 10.4251/wjgo.v12.i2.149
   Curti V, 2020, EFOOD, V1, P140, DOI 10.2991/efood.k.190802.001
   Czarniecka-Skubina E, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18083948
   Dadi D, 2019, INT J RECYCLING ORG, V8, P263, DOI 10.1007/s40093-019-0256-8
   Dadi D, 2018, ECOHYDROL HYDROBIOL, V18, P201, DOI 10.1016/j.ecohyd.2017.10.007
   DaMatta FM, 2019, CLIMATIC CHANGE, V152, P167, DOI 10.1007/s10584-018-2346-4
   Das AK, 2020, TRENDS FOOD SCI TECH, V99, P323, DOI 10.1016/j.tifs.2020.03.010
   Davis AP, 2021, NAT PLANTS, V7, P413, DOI 10.1038/s41477-021-00891-4
   Pereira GVD, 2020, ADV FOOD NUTR RES, V91, P65, DOI 10.1016/bs.afnr.2019.10.002
   Déchamp E, 2015, METHODS MOL BIOL, V1224, P275, DOI 10.1007/978-1-4939-1658-0_22
   DEENI YY, 1991, J ETHNOPHARMACOL, V35, P91, DOI 10.1016/0378-8741(91)90137-3
   del Castillo MD, 2002, J AGR FOOD CHEM, V50, P3698, DOI 10.1021/jf011702q
   DePaula J, 2019, BEVERAGES, V5, DOI 10.3390/beverages5020037
   Desideri E, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081926
   Dietz C, 2017, CURR PHARM DESIGN, V23, P2876, DOI 10.2174/1381612823666170105151800
   Dirks-Naylor AJ, 2015, LIFE SCI, V143, P182, DOI 10.1016/j.lfs.2015.11.005
   Ditano-Vázquez P, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112833
   Doepker C, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101536
   Scholz MBD, 2016, EUPHYTICA, V209, P429, DOI 10.1007/s10681-016-1653-y
   Duangjai A, 2021, PREV NUTR FOOD SCI, V26, P338, DOI 10.3746/pnf.2021.26.3.338
   Eghbaliferiz S, 2016, PHYTOTHER RES, V30, P1379, DOI 10.1002/ptr.5643
   Eguchi N, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22041509
   Ehlers A, 2019, FOOD CHEM TOXICOL, V130, P109, DOI 10.1016/j.fct.2019.05.028
   Eisma JH, 2015, WORLD J DIABETES, V6, P312, DOI 10.4239/wjd.v6.i2.312
   Elnour MAA, 2019, BMC RES NOTES, V12, DOI 10.1186/s13104-019-4838-3
   Elwahab HA, 2017, The role of the GSH system in regulating the levels of ROS neutralisation in the endothelial cells of the blood-brain barrier
   Esposito K, 2009, ANN INTERN MED, V151, P591, DOI 10.7326/0003-4819-151-8-200910200-00026
   Evans PL, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102432
   Farah A., 2015, COFFEE HLTH DIS PREV, P789, DOI 10.1016/B978-0-12-409517-5.00087-5
   Faraji H, 2018, INT J PREVENTIVE MED, V9, DOI 10.4103/ijpvm.IJPVM_343_17
   Farhat G, 2017, PHYTOTHER RES, V31, P1005, DOI 10.1002/ptr.5830
   Farias-Pereira R, 2019, FOOD SCI BIOTECHNOL, V28, P1287, DOI 10.1007/s10068-019-00662-0
   Flambeau KJ, 2017, FOOD SCI BIOTECHNOL, V26, P1245, DOI 10.1007/s10068-017-0168-1
   Fratantonio D, 2017, BIOFACTORS, V43, P54, DOI 10.1002/biof.1312
   Gao F, 2018, NUTR METAB, V15, DOI 10.1186/s12986-018-0321-8
   García-Gutiérrez N, 2017, J FUNCT FOODS, V30, P237, DOI 10.1016/j.jff.2017.01.014
   Gaschler MM, 2017, BIOCHEM BIOPH RES CO, V482, P419, DOI 10.1016/j.bbrc.2016.10.086
   Ghamdi A, 2020, bioRxiv
   Girma B., 2021, Agricul. Forestry Fisheries, V10, P208, DOI [10.11648/j.aff.20211006.11, DOI 10.11648/J.AFF.20211006.11]
   Goodarzi MO, 2018, LANCET DIABETES ENDO, V6, P223, DOI 10.1016/S2213-8587(17)30200-0
   Gorji Z, 2019, PHYTOMEDICINE, V63, DOI 10.1016/j.phymed.2019.153018
   Greenberg JA, 2006, AM J CLIN NUTR, V84, P682, DOI 10.1093/ajcn/84.4.682
   Greenway F L, 2001, Obes Rev, V2, P199, DOI 10.1046/j.1467-789x.2001.00038.x
   Gunning Y, 2018, FOOD CHEM, V248, P52, DOI 10.1016/j.foodchem.2017.12.034
   Gurley BJ, 2015, CLIN THER, V37, P275, DOI 10.1016/j.clinthera.2014.08.012
   Haida Z, 2019, FOOD SCI NUTR, V7, P1555, DOI 10.1002/fsn3.1012
   Hameed A., 2020, COEVOLUTION SECONDAR, P641, DOI [10.1007/978-3-319-96397-6_21, DOI 10.1007/978-3-319-96397-6_21]
   Hang D, 2020, DIABETES CARE, V43, P2588, DOI 10.2337/dc20-0800
   Haskell-Ramsay CF, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101386
   Herrera JC, 2017, CRAFT AND SCIENCE OF COFFEE, P1, DOI 10.1016/B978-0-12-803520-7.00001-3
   Hirono-hara Yoko, 2021, Bioresource Technology Reports, V15, DOI 10.1016/j.biteb.2021.100777
   Ho YCL, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph182010907
   Holohan KE, 2015, Collecting the new world at the Spanish habsburg court, P1519
   Hopkins ND, 2015, J APPL PHYSIOL, V119, P926, DOI 10.1152/japplphysiol.01113.2014
   Hussain A, 2016, ARCH PHARM PRACT, V7, P30, DOI 10.4103/2045-080X.174943
   Ighodaro OM, 2018, BIOMED PHARMACOTHER, V108, P656, DOI 10.1016/j.biopha.2018.09.058
   Imamura F, 2019, J NUTR, V149, P1985, DOI 10.1093/jn/nxz156
   Incalza MA, 2018, VASC PHARMACOL, V100, P1, DOI 10.1016/j.vph.2017.05.005
   International Diabetes Federation, 2017, IDF Diabetes Atlas, V8th
   Inzucchi SE, 2015, DIABETES CARE, V38, P140, DOI 10.2337/dc14-2441
   Jaiswal N, 2019, MOL METAB, V28, P1, DOI 10.1016/j.molmet.2019.08.001
   Jang H, 2015, MOL NUTR FOOD RES, V59, P1918, DOI 10.1002/mnfr.201400897
   Jeon JS, 2017, J CHROMATOGR B, V1064, P115, DOI 10.1016/j.jchromb.2017.08.041
   Jokura H, 2015, NUTR RES, V35, P873, DOI 10.1016/j.nutres.2015.07.005
   Jung S, 2017, J MED FOOD, V20, P626, DOI 10.1089/jmf.2017.3935
   Kaatabi H, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0113486
   Karevanpour F, 2022, ANDROLOGIA, V54, DOI 10.1111/and.14560
   Kath J, 2021, CLIM RISK MANAG, V32, DOI 10.1016/j.crm.2021.100281
   Kennedy L, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10101429
   Kenny HC, 2019, CIRC RES, V124, P121, DOI 10.1161/CIRCRESAHA.118.311371
   Kiwuka C., 2020, Genetic diversity and phenotypic variation of wild, feral and cultivated Coffea canephora in relation to drought stress
   Klingel T, 2020, FOODS, V9, DOI 10.3390/foods9050665
   Kobayashi M, 2017, J NUTR SCI VITAMINOL, V63, P200, DOI 10.3177/jnsv.63.200
   Kouli GM, 2017, NUTR METAB CARDIOVAS, V27, P881, DOI 10.1016/j.numecd.2017.06.015
   Król K, 2020, EUR FOOD RES TECHNOL, V246, P33, DOI 10.1007/s00217-019-03388-9
   Kumar Naresh, 2019, Biotechnology Reports, V24, pe00370, DOI 10.1016/j.btre.2019.e00370
   Kumsa L, 2016, GLOB ECOL CONSERV, V8, P230, DOI 10.1016/j.gecco.2016.09.012
   Kwok MK, 2016, SCI REP-UK, V6, DOI 10.1038/srep36500
   Lara-Guzmán OJ, 2021, FREE RADICAL BIO MED, V176, P345, DOI 10.1016/j.freeradbiomed.2021.10.012
   Lee AH, 2016, NUTR DIABETES, V6, DOI 10.1038/nutd.2016.19
   Lee A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061274
   Lee HJ, 2022, SCI REP-UK, V12, DOI [10.1038/s41598-022-07192-6, 10.1109/SC41404.2022.00056]
   Lee J, 2017, NUTRIENTS, V9, DOI 10.3390/nu9121340
   Lee JH, 2016, KOREAN J FAM MED, V37, P7, DOI 10.4082/kjfm.2016.37.1.7
   Leung PS, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030147
   Leyva-López N, 2021, MOLECULES, V26, DOI 10.3390/molecules26206195
   Li X, 2021, FOOD CHEM, V358, DOI 10.1016/j.foodchem.2021.129837
   Liang NJ, 2019, MOL CELL BIOCHEM, V457, P105, DOI 10.1007/s11010-019-03516-9
   Liang N, 2016, NUTRIENTS, V8, DOI 10.3390/nu8010016
   Lin DR, 2016, MOLECULES, V21, DOI 10.3390/molecules21101374
   Lopez M. E., 2021, Beverage Plant Res., V1, P1, DOI DOI 10.48130/BPR-2021-0013
   Loureiro LMR, 2021, NUTRIENTS, V13, DOI 10.3390/nu13103335
   Lu HJ, 2020, COMPR REV FOOD SCI F, V19, P3130, DOI 10.1111/1541-4337.12620
   Lukitasari M, 2020, F1000Research, V9
   Ma Y, 2016, Handb. Funct. Beverages hum. Heal, P701
   Magliano DJ, 2015, Int Textb Diabetes Mellit, P1
   Mansour A, 2021, NUTR J, V20, DOI 10.1186/s12937-021-00694-5
   Maranta F, 2021, ADV EXP MED BIOL, V1307, P129, DOI 10.1007/5584_2020_514
   Martini D, 2021, NUTRIENTS, V13, DOI 10.3390/nu13072399
   Martini D, 2021, EUR J NUTR, V60, P1453, DOI 10.1007/s00394-020-02347-5
   Martini D, 2016, MOLECULES, V21, DOI 10.3390/molecules21080979
   Martins IJ., 2017, J Diabetes Metab Disord, V4, P1, DOI DOI 10.24966/DMD-201X/100019
   Marventano S, 2016, CLIN NUTR, V35, P1269, DOI 10.1016/j.clnu.2016.03.012
   Mathieu-Fritz A, 2017, REV ANTHROPOL CONNAI, V11, DOI 10.3917/rac.037.k
   Mbata O, 2017, WORLD J DIABETES, V8, P317, DOI 10.4239/wjd.v8.i7.317
   McFarland B J., 2018, Conservation of Tropical Rainforests, P7, DOI DOI 10.1007/978-3-319-63236-0_2
   Melik Z, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0214919
   Metwally DM, 2020, J FUNCT FOODS, V75, DOI 10.1016/j.jff.2020.104202
   Milanlouei S, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-19888-2
   Miranda AM, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030276
   Mirmiran R, 2018, NUTR METAB CARDIOVAS, V28, P1261, DOI 10.1016/j.numecd.2018.09.001
   Moeenfard M, 2020, FOOD RES INT, V134, DOI 10.1016/j.foodres.2020.109207
   Molehin OR, 2020, Role of Oxidative Stress in Pathophysiology of Diseases, P277, DOI [10.1007/978-981-15-1568-2_16, DOI 10.1007/978-981-15-1568-2_16]
   Moon SM, 2021, NUTRIENTS, V13, DOI 10.3390/nu13113976
   Morris Jonathan., 2018, COFFEE GLOBAL HIST
   Mozaffarian D, 2016, CIRCULATION, V133, P187, DOI 10.1161/CIRCULATIONAHA.115.018585
   Muschler RG, 2016, TROPICAL FORESTRY HANDBOOK, 2ND EDITION, P2013, DOI 10.1007/978-3-642-54601-3_300
   Nabavi SF, 2017, CURR NEUROPHARMACOL, V15, P471, DOI 10.2174/1570159X14666160325120625
   Nakazawa Y, 2019, EXP THER MED, V17, P1420, DOI 10.3892/etm.2018.7092
   Navarro AM, 2018, AM J CLIN NUTR, V108, P1113, DOI 10.1093/ajcn/nqy198
   Naylor LH, 2021, AM J CLIN NUTR, V113, P370, DOI 10.1093/ajcn/nqaa312
   Nemzer B, 2021, MOLECULES, V26, DOI 10.3390/molecules26144306
   Nogaim QA, 2020, TOXICOL REP, V7, P142, DOI 10.1016/j.toxrep.2019.11.015
   Nop Ranking, 2022, World obesity Atlas 2022
   Nordestgaard AT, 2016, INT J EPIDEMIOL, V45, P1938, DOI 10.1093/ije/dyw325
   Nordestgaard AT, 2015, INT J EPIDEMIOL, V44, P551, DOI 10.1093/ije/dyv083
   Ogurtsova K, 2017, DIABETES RES CLIN PR, V128, P40, DOI 10.1016/j.diabres.2017.03.024
   Ohishi T, 2021, MOLECULES, V26, DOI 10.3390/molecules26020453
   Omer T., 2020, Advances in Obesity, Weight Management Control, V10, P90, DOI [10.15406/aowmc.2020.10.00312, DOI 10.15406/AOWMC.2020.10.00312]
   Padovan MP, 2015, AGROFOREST SYST, V89, P857, DOI 10.1007/s10457-015-9820-z
   Pahlke G, 2019, J FUNCT FOODS, V55, P285, DOI 10.1016/j.jff.2019.02.008
   Palatini P, 2015, EUR J EPIDEMIOL, V30, P209, DOI 10.1007/s10654-015-9990-z
   Pan MH, 2016, FOOD FUNCT, V7, P4481, DOI 10.1039/c6fo01168c
   Panzella L, 2016, ACS SUSTAIN CHEM ENG, V4, P1169, DOI 10.1021/acssuschemeng.5b01234
   Patay EB, 2017, Coffea arabica: a plant with rich content in caffeine, V27
   Patil S, 2022, PLANTA, V255, DOI 10.1007/s00425-022-03846-x
   Peleli M, 2017, MOL ASPECTS MED, V55, P4, DOI 10.1016/j.mam.2016.12.002
   Perdani CG, 2019, IOP C SER EARTH ENV, V230, DOI 10.1088/1755-1315/230/1/012093
   Pimpley V, 2020, PREP BIOCHEM BIOTECH, V50, P969, DOI 10.1080/10826068.2020.1786699
   Poisson L, 2017, CRAFT AND SCIENCE OF COFFEE, P273, DOI 10.1016/B978-0-12-803520-7.00012-8
   Pouvreau C, 2018, J INFLAMM RES, V11, P61, DOI 10.2147/JIR.S148911
   Powers SK, 2016, FREE RADICAL BIO MED, V98, P208, DOI 10.1016/j.freeradbiomed.2016.02.021
   Poznyak A, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21051835
   Prakash NS, 2018, BURL DODDS AGR SCI, V39, P115, DOI 10.19103/AS.2017.0022.06
   Priftis A, 2019, FOOD CHEM TOXICOL, V125, P305, DOI 10.1016/j.fct.2019.01.012
   Qi QB, 2014, BMJ-BRIT MED J, V348, DOI 10.1136/bmj.g1610
   Qiao Y, 2022, J FOOD SCI, V87, P1672, DOI 10.1111/1750-3841.16098
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   Reis CEG, 2019, J TRADIT COMPL MED, V9, P184, DOI 10.1016/j.jtcme.2018.01.001
   Reis CEG, 2015, Diabetol Metab Syndrome, V7, P1
   Ren YQ, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20174238
   Robertson TM, 2015, P NUTR SOC, V74, pE79, DOI 10.1017/S0029665115000944
   Robertson TM, 2015, BRIT J NUTR, V114, P1218, DOI 10.1017/S0007114515002640
   Loureiro LMR, 2018, INT J SPORT NUTR EXE, V28, P284, DOI 10.1123/ijsnem.2017-0342
   Vegro CLR, 2020, WOODH PUBL SER CONS, P3, DOI 10.1016/B978-0-12-814721-4.00001-9
   Rodríguez-Artalejo F, 2018, J AGR FOOD CHEM, V66, P5257, DOI 10.1021/acs.jafc.7b04506
   Rostagno M.A., 2015, Coffee in Health and Disease Prevention, P137, DOI [DOI 10.1016/B978-0-12-409517-5.00015-2, 10.1016/B978-0-12-409517-5.00015-2]
   Rufian-Henares J. A., 2015, Coffee in health and disease prevention, P853
   Russell WR, 2016, CRIT REV FOOD SCI, V56, P541, DOI 10.1080/10408398.2013.792772
   Salas-Salvadó J, 2019, ADV NUTR, V10, pS320, DOI 10.1093/advances/nmy102
   Salinas-Rios T, 2015, SMALL RUMINANT RES, V123, P17, DOI 10.1016/j.smallrumres.2014.09.008
   Sandoval DA, 2015, PHYSIOL REV, V95, P513, DOI 10.1152/physrev.00013.2014
   Sant'Ana GC, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-017-18800-1
   Santos RMM, 2016, EUR J NUTR, V55, P1345, DOI 10.1007/s00394-016-1206-0
   Schiebinger Londa., 2004, PLANTS EMPIRE COLONI
   Schipp D, 2019, EUR J NUTR, V58, P3199, DOI 10.1007/s00394-018-1863-2
   Schubert MM, 2017, INT J FOOD SCI NUTR, V68, P901, DOI 10.1080/09637486.2017.1320537
   Setti Thiago, 2021, J Clin Orthop Trauma, V15, P145, DOI 10.1016/j.jcot.2020.09.006
   Shahmohammadi HA, 2017, HEPAT MON, V17, DOI 10.5812/hepatmon.45609
   Shahriari Reza, 2020, Traditional Medicine Research, V5, P433, DOI 10.53388/TMR20200603191
   Shao YC, 2017, J DIABETES RES, V2017, DOI 10.1155/2017/2804178
   Shaposhnikov S, 2018, EUR J NUTR, V57, P533, DOI 10.1007/s00394-016-1336-4
   Shateri Z, 2016, J Clin Nutr Diet, V2, P3
   Shi XQ, 2016, NUTR J, V15, DOI 10.1186/s12937-016-0220-7
   Shin S, 2022, INT J EPIDEMIOL, V51, P626, DOI 10.1093/ije/dyab161
   Shokouh P, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092074
   Silveira H. R. de O., 2016, Coffee Science, V11, P318
   Soares PV, 2019, NUTR CANCER, V71, P615, DOI 10.1080/01635581.2018.1506489
   Stefanello N, 2019, FOOD CHEM TOXICOL, V123, P298, DOI 10.1016/j.fct.2018.10.005
   Stojkovski K, 2022, 0 Order, P1
   Stutz B, 2018, NUTR METAB CARDIOVAS, V28, P470, DOI 10.1016/j.numecd.2018.01.011
   Susilawati I. D. A., 2019, IOP Conference Series: Earth and Environmental Science, V293, DOI 10.1088/1755-1315/293/1/012022
   Tagliazucchi D., 2015, Coffee in Health and Disease Prevention, P859, DOI 10.1016/B978- 0-12-409517-5.00095-4
   Tagliazucchi D, 2015, AMINO ACIDS, V47, P1077, DOI 10.1007/s00726-015-1951-z
   Tajik N, 2017, EUR J NUTR, V56, P2215, DOI 10.1007/s00394-017-1379-1
   Tamura H, 2020, YAKUGAKU ZASSHI, V140, P1351, DOI 10.1248/yakushi.20-00150
   Tangvarasittichai S, 2015, WORLD J DIABETES, V6, P456, DOI 10.4239/wjd.v6.i3.456
   Taso O.V., 2019, Annals of Research Hospitals, V3, P2, DOI [DOI 10.21037/ARH.2018.12.02, 10.21037/arh.2018.12.02]
   Teodoro JS, 2020, TOXICOL MECH METHOD, V30, P536, DOI 10.1080/15376516.2020.1780361
   Tesfa M., 2019, J Environ Earth Sci, V9, P30, DOI [10.7176/jees/9-12-04, DOI 10.7176/JEES/9-12-04, 10.7176/JEES/9-12-04]
   Tolessa K, 2017, J SCI FOOD AGR, V97, P2849, DOI 10.1002/jsfa.8114
   Torres-Collado L, 2021, NUTRIENTS, V13, DOI 10.3390/nu13041241
   Tsai KL, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700928
   Tung WC, 2020, ARCH BIOCHEM BIOPHYS, V694, DOI 10.1016/j.abb.2020.108589
   Tverdal A, 2020, EUR J PREV CARDIOL, V27, P1986, DOI 10.1177/2047487320914443
   ul Haq ME, 2020, ENVIRON TOXICOL PHAR, V78, DOI 10.1016/j.etap.2020.103387
   Ullah A, 2016, SAUDI PHARM J, V24, P547, DOI 10.1016/j.jsps.2015.03.013
   Um N., 2015, Asia Inside Out: Changing Times, V1, P112
   van der Vossen H, 2015, EUPHYTICA, V204, P243, DOI 10.1007/s10681-015-1398-z
   Van Long N., 2015, Engineering, V7, P742, DOI DOI 10.4236/ENG.2015.711015
   Vázquez-Sánchez K, 2018, FOOD CHEM, V261, P253, DOI 10.1016/j.foodchem.2018.04.064
   Vendrov AE, 2015, ANTIOXID REDOX SIGN, V23, P1389, DOI 10.1089/ars.2014.6221
   Vidal OL, 2020, INT J BIOL MACROMOL, V146, P730, DOI 10.1016/j.ijbiomac.2019.10.123
   Vlavcheski F, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19051321
   Wang TG, 2017, BMC MED, V15, DOI 10.1186/s12916-017-0862-0
   Wann JW, 2018, SUSTAINABILITY-BASEL, V10, DOI 10.3390/su10072396
   Wei F., 2015, Coffee in health and disease prevention, P83, DOI DOI 10.1016/B978-0-12-409517-5.00010-3
   Wellman FrederickL., 1961, COFFEE BOT CULTIVATI
   Williamson G, 2017, NUTR BULL, V42, P226, DOI 10.1111/nbu.12278
   Williamson G, 2020, NUTRIENTS, V12, DOI 10.3390/nu12103135
   Willson C, 2018, TOXICOL REP, V5, P1140, DOI 10.1016/j.toxrep.2018.11.002
   Winaldi A, 2021, Food Res, V5, P107
   Wolska J, 2017, BIOL TRACE ELEM RES, V179, P327, DOI 10.1007/s12011-017-0963-9
   Worku M, 2015, SMALL-SCALE FOR, V14, P531, DOI 10.1007/s11842-015-9305-y
   Yadessa Abebe, 2020, African Journal of Plant Science, V14, P213, DOI 10.5897/AJPS2020.1976
   Yancy CW, 2018, J AM COLL CARDIOL, V71, P201, DOI 10.1016/j.jacc.2017.11.025
   Yanovski SZ, 2018, JAMA-J AM MED ASSOC, V319, P223, DOI 10.1001/jama.2017.20051
   Yao WQ, 2021, J FUNCT FOODS, V85, DOI 10.1016/j.jff.2021.104615
   Yin X, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/4566949
   Yuan S, 2021, NUTRIENTS, V13, DOI 10.3390/nu13072218
   Zatorski H, 2015, N-S ARCH PHARMACOL, V388, P643, DOI 10.1007/s00210-015-1110-9
   Zeng Z, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201900457
   Zhang ZF, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18010031
   Zheng HT, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.842856
   Zulli A, 2016, EUR J NUTR, V55, P1331, DOI 10.1007/s00394-016-1179-z
NR 289
TC 4
Z9 4
U1 5
U2 12
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1871-4021
EI 1878-0334
J9 DIAB MET SYND CLIN R
JI DIABET. METAB. SYNDR. CLIN. RES. REV.
PD JUL
PY 2024
VL 18
IS 7
AR 103075
DI 10.1016/j.dsx.2024.103075
EA JUL 2024
PG 17
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA A6K2Q
UT WOS:001283597900001
PM 39067326
OA hybrid
DA 2025-06-11
ER

PT J
AU Soto-Angona, O
   Anmella, G
   Valdés-Florido, MJ
   De Uribe-Viloria, N
   Carvalho, AF
   Penninx, BWJH
   Berk, M
AF Soto-Angona, Oscar
   Anmella, Gerard
   Valdes-Florido, Maria Jose
   De Uribe-Viloria, Nieves
   Carvalho, Andre F.
   Penninx, Brenda W. J. H.
   Berk, Michael
TI Non-alcoholic fatty liver disease (NAFLD) as a neglected metabolic
   companion of psychiatric disorders: common pathways and future
   approaches
SO BMC MEDICINE
LA English
DT Review
DE Non-alcoholic fatty liver disease; Metabolic syndrome; Mental disorders;
   Psychiatry; Non-alcoholic steatohepatitis; Non-communicable disorders;
   Lifestyle; Inflammation; Oxidative stress; Mitochondrial
ID BIPOLAR DISORDER; OXIDATIVE STRESS; MENTAL-DISORDERS; RISK-FACTORS;
   HISTOLOGICAL SEVERITY; GLOBAL EPIDEMIOLOGY; PSYCHOTIC DISORDERS;
   GENDER-DIFFERENCES; PHYSICAL-ACTIVITY; GUT-MICROBIOTA
AB Background Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis in over 5% of the parenchyma in the absence of excessive alcohol consumption. It is more prevalent in patients with diverse mental disorders, being part of the comorbidity driving loss of life expectancy and quality of life, yet remains a neglected entity. NAFLD can progress to non-alcoholic steatohepatitis (NASH) and increases the risk for cirrhosis and hepatic carcinoma. Both NAFLD and mental disorders share pathophysiological pathways, and also present a complex, bidirectional relationship with the metabolic syndrome (MetS) and related cardiometabolic diseases. Main text This review compares the demographic data on NAFLD and NASH among the global population and the psychiatric population, finding differences that suggest a higher incidence of this disease among the latter. It also analyzes the link between NAFLD and psychiatric disorders, looking into common pathophysiological pathways, such as metabolic, genetic, and lifestyle factors. Finally, possible treatments, tailored approaches, and future research directions are suggested. Conclusion NAFLD is part of a complex system of mental and non-communicable somatic disorders with a common pathogenesis, based on shared lifestyle and environmental risks, mediated by dysregulation of inflammation, oxidative stress pathways, and mitochondrial function. The recognition of the prevalent comorbidity between NAFLD and mental disorders is required to inform clinical practice and develop novel interventions to prevent and treat these complex and interacting disorders.
C1 [Soto-Angona, Oscar] Vall dHebron Univ Hosp, Dept Psychiat, Passeig Vall dHebron,119-129, Barcelona 08035, Catalonia, Spain.
   [Soto-Angona, Oscar; Anmella, Gerard; De Uribe-Viloria, Nieves; Carvalho, Andre F.; Berk, Michael] Deakin Univ, Inst Mental & Phys Hlth & Clin Translat, Sch Med, IMPACT,Barwon Hlth, Geelong, Vic, Australia.
   [Anmella, Gerard] Univ Barcelona, Bipolar & Depress Disorders Unit, Inst Neurosci, Hosp Clin,IDIBAPS,CIBERSAM, 170 Villarroel St,12-0, Barcelona 08036, Catalonia, Spain.
   [Valdes-Florido, Maria Jose] Hosp Univ Virgen Macarena, UGC Salud Mental, Seville, Spain.
   [De Uribe-Viloria, Nieves] Hosp Clin Univ Valladolid, Dept Psychiat, Valladolid, Castilla & Leon, Spain.
   [Carvalho, Andre F.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Carvalho, Andre F.] Ctr Addict & Mental Hlth CAMH, Toronto, ON, Canada.
   [Penninx, Brenda W. J. H.] Vrije Univ, Amsterdam Univ, Dept Psychiat, Amsterdam Publ Hlth,Med Ctr, Amsterdam, Netherlands.
   [Penninx, Brenda W. J. H.] Vrije Univ, Amsterdam Univ, Med Ctr, Amsterdam Neurosci, Amsterdam, Netherlands.
   [Berk, Michael] GGZinGeest, Amsterdam, Netherlands.
   [Berk, Michael] Univ Melbourne, Natl Ctr Excellence Youth Mental Hlth, Dept Psychiat, Orygen, Parkville, Vic, Australia.
   [Berk, Michael] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia.
C3 Hospital Universitari Vall d'Hebron; Barwon Health; Deakin University;
   CIBER - Centro de Investigacion Biomedica en Red; CIBERSAM; University
   of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Hospital
   Universitario Virgen Macarena; Universidad de Valladolid; University
   Hospital of Valladolid; University of Toronto; University of Toronto;
   Centre for Addiction & Mental Health - Canada; University of Amsterdam;
   Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; University
   of Amsterdam; Orygen, The National Centre of Excellence in Youth Mental
   Health; University of Melbourne; Florey Institute of Neuroscience &
   Mental Health; University of Melbourne
RP Soto-Angona, O (corresponding author), Vall dHebron Univ Hosp, Dept Psychiat, Passeig Vall dHebron,119-129, Barcelona 08035, Catalonia, Spain.; Soto-Angona, O (corresponding author), Deakin Univ, Inst Mental & Phys Hlth & Clin Translat, Sch Med, IMPACT,Barwon Hlth, Geelong, Vic, Australia.
EM osoto@vhebron.net
RI Berk, Michael/AGH-9427-2022; Diaz, Gerard/AAB-7311-2021; Carvalho,
   Andre/AEZ-4001-2022; Berk, Michael/M-7891-2013; Penninx, Brenda
   WJH/S-7627-2017
OI Berk, Michael/0000-0002-5554-6946; Penninx, Brenda
   WJH/0000-0001-7779-9672; Valdes-Florido, Maria Jose/0000-0001-6036-842X;
   Soto-Angona, Oscar/0000-0003-0234-4280
FU NHMRC Senior Principal Research Fellowship [1156072]
FX MB is supported by a NHMRC Senior Principal Research Fellowship
   (1156072).
CR Ajmera V, 2017, HEPATOLOGY, V65, P65, DOI 10.1002/hep.28776
   Alural B, 2017, PROG NEURO-PSYCHOPH, V73, P87, DOI 10.1016/j.pnpbp.2016.03.010
   Angulo P, 2002, NEW ENGL J MED, V346, P1221, DOI 10.1038/nrdp.2015.80
   [Anonymous], 2017, INT J MOL SCI, DOI DOI 10.3390/ijms18030651
   Anty R, 2019, PRESSE MED, V48, P1468, DOI 10.1016/j.lpm.2019.09.051
   Araújo AR, 2018, LIVER INT, V38, P47, DOI 10.1111/liv.13643
   Armstrong MJ, 2010, NEW ENGL J MED, V363, P1185, DOI 10.1056/NEJMc1006581
   Ballestri S, 2019, EXPERT REV GASTROENT, V13, P667, DOI 10.1080/17474124.2019.1621164
   Barbuti M, 2017, J AFFECT DISORDERS, V221, P97, DOI 10.1016/j.jad.2017.06.019
   Bedogni G, 2006, BMC GASTROENTEROL, V6, DOI 10.1186/1471-230X-6-33
   Bellentani S, 2017, LANCET GASTROENTEROL, V2, P547, DOI 10.1016/S2468-1253(17)30146-2
   DUARTE Sebastião Mauro Bezerra, 2019, Arq. Gastroenterol., V56, P431, DOI [10.1590/S0004-2803.201900000-67, 10.1590/s0004-2803.201900000-67]
   Black CN, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.5
   Black CN, 2017, PSYCHONEUROENDOCRINO, V80, P56, DOI 10.1016/j.psyneuen.2017.03.003
   Black CN, 2015, PSYCHONEUROENDOCRINO, V51, P164, DOI 10.1016/j.psyneuen.2014.09.025
   Black N, 2019, LANCET PSYCHIAT, V6, P995, DOI 10.1016/S2215-0366(19)30401-8
   Boyle M, 2018, J HEPATOL, V68, P251, DOI 10.1016/j.jhep.2017.11.006
   Bremmer MA, 2008, J AFFECT DISORDERS, V106, P249, DOI 10.1016/j.jad.2007.07.002
   Buch S, 2015, NAT GENET, V47, P1443, DOI 10.1038/ng.3417
   Buzzetti E, 2016, METABOLISM, V65, P1038, DOI 10.1016/j.metabol.2015.12.012
   Caldwell SH, 1999, J HEPATOL, V31, P430, DOI 10.1016/S0168-8278(99)80033-6
   Cenit MC, 2017, WORLD J GASTROENTERO, V23, P5486, DOI 10.3748/wjg.v23.i30.5486
   Carpita B, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/3717215
   Carrier P, 2016, HEPAT MON, V16, DOI 10.5812/hepatmon.41564
   Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI 10.1002/hep.29367
   Chesney E, 2014, WORLD PSYCHIATRY, V13, P153, DOI 10.1002/wps.20128
   Colca J, 2020, EXPERT OPIN INV DRUG, V29, P191, DOI 10.1080/13543784.2020.1715940
   Cooper ME, 2014, BRIT J CLIN PHARMACO, V77, P21, DOI 10.1111/bcp.12102
   Cortez-Pinto H, 1999, JAMA-J AM MED ASSOC, V282, P1659, DOI 10.1001/jama.282.17.1659
   Czarny P, 2018, PROG NEURO-PSYCHOPH, V80, P309, DOI 10.1016/j.pnpbp.2017.06.036
   Dash S, 2015, CURR OPIN PSYCHIATR, V28, P1, DOI 10.1097/YCO.0000000000000117
   Davis J, 2016, NEUROSCI BIOBEHAV R, V65, P185, DOI 10.1016/j.neubiorev.2016.03.017
   Hert M, 2012, NAT REV ENDOCRINOL, V8, P114, DOI 10.1038/nrendo.2011.156
   Dinan TG, 2017, PSYCHOSOM MED, V79, P920, DOI 10.1097/PSY.0000000000000519
   Dongiovanni P, 2015, J HEPATOL, V63, P705, DOI 10.1016/j.jhep.2015.05.006
   Dongiovanni P, 2013, CURR PHARM DESIGN, V19, P5219, DOI 10.2174/13816128113199990381
   Druss Benjamin G, 2011, Synth Proj Res Synth Rep, P1
   EASL, 2016, OBESITY FACTS, V9, P65, DOI [10.1159/000443344, 10.1007/s00125-016-3902-y, 10.1016/j.jhep.2015.11.004]
   Elwing JE, 2006, PSYCHOSOM MED, V68, P563, DOI 10.1097/01.psy.0000221276.17823.df
   Eslam M, 2020, J HEPATOL, V73, P202, DOI 10.1016/j.jhep.2020.03.039
   Eslam M, 2018, J HEPATOL, V68, P268, DOI 10.1016/j.jhep.2017.09.003
   Filiou MD, 2019, TRENDS NEUROSCI, V42, P573, DOI 10.1016/j.tins.2019.07.002
   Fraguas D, 2017, INT J NEUROPSYCHOPH, V20, P435, DOI 10.1093/ijnp/pyx015
   Fuller BE, 2011, GEN HOSP PSYCHIAT, V33, P232, DOI 10.1016/j.genhosppsych.2011.03.006
   Fung TC, 2017, NAT NEUROSCI, V20, P145, DOI 10.1038/nn.4476
   Gibson D, 2019, PSYCHIAT CLIN N AM, V42, P263, DOI 10.1016/j.psc.2019.01.009
   Green J, 2019, AUST NZ J PSYCHIAT, V53, P732, DOI 10.1177/0004867419839776
   Hsu JH, 2016, GEN HOSP PSYCHIAT, V42, P54, DOI 10.1016/j.genhosppsych.2016.07.006
   Jantaratnotai N, 2017, OBES RES CLIN PRACT, V11, P1, DOI 10.1016/j.orcp.2016.07.003
   Morlán-Coarasa MJ, 2016, PSYCHOPHARMACOLOGY, V233, P3947, DOI 10.1007/s00213-016-4422-7
   Kenneson A, 2017, J AFFECT DISORDERS, V209, P93, DOI 10.1016/j.jad.2016.11.035
   Kim N, 2018, J MICROBIOL, V56, P172, DOI 10.1007/s12275-018-8032-4
   Kim SW, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00103
   Koehler EM, 2012, J HEPATOL, V57, P1305, DOI 10.1016/j.jhep.2012.07.028
   Köhler CA, 2018, J PSYCHIATR RES, V103, P189, DOI 10.1016/j.jpsychires.2018.05.020
   Kolodziejczyk AA, 2019, EMBO MOL MED, V11, DOI 10.15252/emmm.201809302
   Konttinen H, 2010, AM J CLIN NUTR, V92, P1031, DOI 10.3945/ajcn.2010.29732
   Lonardo A., 2020, Explor Med, V1, P85
   Lonardo A, 2020, ANN HEPATOL, V19, P359, DOI 10.1016/j.aohep.2020.03.001
   Lonardo A, 2020, HEPATOBIL SURG NUTR, V9, P374, DOI 10.21037/hbsn.2019.11.12
   Lonardo A, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20112841
   Lonardo A, 2018, J HEPATOL, V68, P335, DOI 10.1016/j.jhep.2017.09.021
   Loomba R, 2015, GASTROENTEROLOGY, V149, P1784, DOI 10.1053/j.gastro.2015.08.011
   Ma JL, 2017, NUTRIENTS, V9, DOI 10.3390/nu9101124
   Maas DA, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/tp.2017.138
   Macavei B, 2016, EUR REV MED PHARMACO, V20, P5081
   Machado MV, 2013, J HEPATOL, V58, P1007, DOI 10.1016/j.jhep.2012.11.021
   Marx W, 2017, P NUTR SOC, V76, P427, DOI 10.1017/S0029665117002026
   Masarone M, 2014, REV RECENT CLIN TRIA, V9, P126, DOI 10.2174/1574887109666141216111143
   Menghini-Müller S, 2019, EUR PSYCHIAT, V59, P52, DOI 10.1016/j.eurpsy.2019.04.007
   Mikkelsen K, 2017, MATURITAS, V106, P48, DOI 10.1016/j.maturitas.2017.09.003
   Milaneschi Y, 2020, BIOL PSYCHIAT, V88, P369, DOI 10.1016/j.biopsych.2020.01.014
   Milaneschi Y, 2019, MOL PSYCHIATR, V24, P18, DOI 10.1038/s41380-018-0017-5
   Miller MW, 2018, HARVARD REV PSYCHIAT, V26, P57, DOI 10.1097/HRP.0000000000000167
   Momen NC, 2020, NEW ENGL J MED, V382, P1721, DOI 10.1056/NEJMoa1915784
   Morris G, 2017, NEUROSCI BIOBEHAV R, V74, P1, DOI 10.1016/j.neubiorev.2017.01.014
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Moulton CD, 2018, PSYCHONEUROENDOCRINO, V94, P91, DOI 10.1016/j.psyneuen.2018.05.010
   Muneer Ather, 2016, Chonnam Med J, V52, P18, DOI 10.4068/cmj.2016.52.1.18
   Oni ET, 2015, AM J CARDIOL, V115, P34, DOI 10.1016/j.amjcard.2014.09.044
   Pan JJ, 2014, WORLD J HEPATOL, V6, P274, DOI 10.4254/wjh.v6.i5.274
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Pereira C, 2018, INT J NEUROPSYCHOPH, V21, P550, DOI 10.1093/ijnp/pyy018
   Povero D, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0113651
   Riecher-Rössler A, 2018, ARCH WOMEN MENT HLTH, V21, P627, DOI 10.1007/s00737-018-0847-9
   Rinella ME, 2015, JAMA-J AM MED ASSOC, V313, P2263, DOI 10.1001/jama.2015.5370
   Rosenblat JD, 2017, BRAIN SCI, V7, DOI 10.3390/brainsci7110144
   Sahota PKC, 2008, J CLIN PSYCHIAT, V69, P800, DOI 10.4088/JCP.v69n0513
   Salazar P, 2019, MOL NEUROBIOL, V56, P2952, DOI 10.1007/s12035-018-1270-y
   Salk RH, 2017, PSYCHOL BULL, V143, P783, DOI 10.1037/bul0000102
   Sanyal AJ, 2001, GASTROENTEROLOGY, V120, P1183, DOI 10.1053/gast.2001.23256
   Satapathy SK, 2015, SEMIN LIVER DIS, V35, P221, DOI 10.1055/s-0035-1562943
   Scott KM, 2016, JAMA PSYCHIAT, V73, P150, DOI 10.1001/jamapsychiatry.2015.2688
   Shah AG, 2009, CLIN GASTROENTEROL H, V7, P1104, DOI 10.1016/j.cgh.2009.05.033
   Sheka AC, 2020, JAMA-J AM MED ASSOC, V323, P1175, DOI 10.1001/jama.2020.2298
   Sinha RA, 2018, NAT REV ENDOCRINOL, V14, P259, DOI 10.1038/nrendo.2018.10
   Smaga I, 2015, PHARMACOL REP, V67, P569, DOI 10.1016/j.pharep.2014.12.015
   Solmi M, 2018, EUR J CLIN INVEST, V48, DOI 10.1111/eci.12982
   Sookoian S, 2011, HEPATOLOGY, V53, P1883, DOI 10.1002/hep.24283
   Stefan N, 2019, LANCET DIABETES ENDO, V7, P313, DOI 10.1016/S2213-8587(18)30154-2
   Stefan N, 2017, CELL METAB, V26, P292, DOI 10.1016/j.cmet.2017.07.008
   Stewart KE, 2015, LIVER INT, V35, P936, DOI 10.1111/liv.12483
   Tan YW, 2014, PLOS ONE, V9, DOI [10.1371/journal.pone.0105192, 10.1371/journal.pone.0094264]
   Upthegrove R, 2020, CURR TOP BEHAV NEURO, V44, P49, DOI 10.1007/7854_2018_88
   Vallet-Pichard A, 2019, PRESSE MED, V48, P1459, DOI 10.1016/j.lpm.2019.08.008
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Weinstein AA, 2016, PM&R, V8, P28, DOI 10.1016/j.pmrj.2015.06.001
   Weinstein AA, 2011, PSYCHOSOMATICS, V52, P127, DOI 10.1016/j.psym.2010.12.019
   White DL, 2012, CLIN GASTROENTEROL H, V10, P1342, DOI 10.1016/j.cgh.2012.10.001
   Wiesner G, 2004, J ENDOCRINOL, V180, pR1, DOI 10.1677/joe.0.180R001
   Wong RJ, 2014, HEPATOLOGY, V59, P2188, DOI 10.1002/hep.26986
   Wu H, 2016, GUT, V65, P1850, DOI 10.1136/gutjnl-2014-308430
   Yan J, 2017, NEUROPSYCH DIS TREAT, V13, P1493, DOI 10.2147/NDT.S137183
   Younossi ZM, 2019, CLIN GASTROENTEROL H, V17, P2093, DOI 10.1016/j.cgh.2019.01.001
   Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431
   Youssef NA, 2013, LIVER INT, V33, P1062, DOI 10.1111/liv.12165
   Zarrinpar A, 2016, GUT, V65, P1546, DOI 10.1136/gutjnl-2015-309456
NR 117
TC 75
Z9 77
U1 3
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1741-7015
J9 BMC MED
JI BMC Med.
PD OCT 1
PY 2020
VL 18
IS 1
AR 261
DI 10.1186/s12916-020-01713-8
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA NZ2PR
UT WOS:000576939100001
PM 32998725
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Eirin, A
   Woollard, JR
   Ferguson, CM
   Jordan, KL
   Tang, H
   Textor, SC
   Lerman, A
   Lerman, LO
AF Eirin, Alfonso
   Woollard, John R.
   Ferguson, Christopher M.
   Jordan, Kyra L.
   Tang, Hui
   Textor, Stephen C.
   Lerman, Amir
   Lerman, Lilach O.
TI The metabolic syndrome induces early changes in the swine renal
   medullary mitochondria
SO TRANSLATIONAL RESEARCH
LA English
DT Article
ID GLOMERULAR-FILTRATION-RATE; OXYGEN SPECIES GENERATION; OXIDATIVE STRESS;
   KIDNEY-DISEASE; BOLD MRI; REVASCULARIZATION; HYPERFILTRATION; APOPTOSIS;
   HEMODYNAMICS; PROTECTION
AB The metabolic syndrome (MetS) is associated with nutrient surplus and kidney hyperfiltration, accelerating chronic renal failure. Mitochondria can be overwhelmed by substrate excess, leading to inefficient energy production and thereby tissue hypoxia. Mitochondrial dysfunction is emerging as an important determinant of renal damage, but whether it contributes to MetS-induced renal injury remains unknown. We hypothesized that early MetS induces kidney mitochondrial abnormalities and dysfunction, which would be notable in the vulnerable renal medulla. Pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with the mitochondria-targeted peptide elami-pretide (0.1 mg/kg SC q.d), and Lean controls (n = 7 each). Single-kidney renal blood flow, glomerular filtration rate, and oxygenation were measured in-vivo, whereas cortical and medullary mitochondrial structure and function and renal injurious pathways were studied ex-vivo. Blood pressure was slightly elevated in MetS pigs, and their renal blood flow and glomerular filtration rate were elevated. Blood oxygen level-dependent magnetic resonance imaging demonstrated that this was associated with medullary hypoxia, whereas cortical oxygenation remained intact. MetS decreased renal content of the inner mitochondrial membrane cardiolipin, particularly the tetra-linoleoyl (C18:2) cardiolipin species, and altered mitochondrial morphology and function, particularly in the medullary thick ascending limb. MetS also increased renal cytochrome-c-induced apoptosis, oxidative stress, and tubular injury. Chronic mitoprotection restored mitochondrial structure, ATP synthesis, and antioxidant defenses and decreased mitochondrial oxidative stress, medullary hypoxia, and renal injury. These findings implicate medullary mitochondrial damage in renal injury in experimental MetS, and position the mitochondria as a therapeutic target.
C1 [Lerman, Lilach O.] Mayo Clin, Div Nephrol & Hypertens, 200 First St SW, Rochester, MN 55905 USA.
   Mayo Clin, Cardiovasc Dis, Rochester, MN USA.
C3 Mayo Clinic; Mayo Clinic
RP Lerman, LO (corresponding author), Mayo Clin, Div Nephrol & Hypertens, 200 First St SW, Rochester, MN 55905 USA.
EM Lerman.Lilach@Mayo.Edu
RI Lerman, Lilach/M-4962-2017; Eirin, Alfonso/N-9873-2013
OI Eirin, Alfonso/0000-0002-3864-9644
FU Stealth Biotherapeutics, Inc; NIH [DK73608, DK106427, DK104273,
   HL123160, DK102325]
FX This work was supported by a research grant from Stealth
   Biotherapeutics, Inc, and from the NIH (DK73608, DK106427, DK104273,
   HL123160, and DK102325).
CR Beltowski J, 2010, J PHARMACOL EXP THER, V334, P358, DOI 10.1124/jpet.110.166637
   Birk AV, 2013, J AM SOC NEPHROL, V24, P1250, DOI 10.1681/ASN.2012121216
   Bonegio R, 2002, CURR OPIN NEPHROL HY, V11, P301, DOI 10.1097/00041552-200205000-00006
   Brown DA, 2014, J CARDIOVASC PHARM T, V19, P121, DOI 10.1177/1074248413508003
   Cameron AJ, 2004, ENDOCRIN METAB CLIN, V33, P351, DOI 10.1016/j.ecl.2004.03.005
   Ebrahimi B, 2012, INVEST RADIOL, V47, P175, DOI 10.1097/RLI.0b013e318234e75b
   Eirin A, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.115.003118
   Eirin A, 2014, CARDIOVASC RES, V103, P461, DOI 10.1093/cvr/cvu157
   Eirin A, 2012, HYPERTENSION, V60, P1242, DOI 10.1161/HYPERTENSIONAHA.112.199919
   Eirin A, 2012, CIRC-CARDIOVASC INTE, V5, P720, DOI 10.1161/CIRCINTERVENTIONS.112.972596
   Eirin A, 2012, STEM CELLS, V30, P1030, DOI 10.1002/stem.1047
   Eirin A, 2011, AM J PHYSIOL-RENAL, V300, pF1394, DOI 10.1152/ajprenal.00697.2010
   ELMOTAL SMA, 1985, ENDOCRINOLOGY, V116, P2337, DOI 10.1210/endo-116-6-2337
   Ferraro PM, 2011, METAB SYNDR RELAT D, V9, P381, DOI 10.1089/met.2011.0040
   Gloviczki ML, 2011, CURR HYPERTENS REP, V13, P370, DOI 10.1007/s11906-011-0218-7
   Higgins GC, 2014, BRIT J PHARMACOL, V171, P1917, DOI 10.1111/bph.12503
   Huang QH, 2015, CIRCULATION, V131, P1082, DOI 10.1161/CIRCULATIONAHA.114.012725
   Jialal I, 2012, J CLIN ENDOCR METAB, V97, pE1844, DOI 10.1210/jc.2012-2498
   Kaminski M, 2004, MICROSC RES TECHNIQ, V64, P255, DOI 10.1002/jemt.20083
   Kloner RA, 2012, J AM HEART ASSOC, V1, DOI 10.1161/JAHA.112.001644
   Krier JD, 2001, AM J PHYSIOL-RENAL, V281, pF630, DOI 10.1152/ajprenal.2001.281.4.F630
   Li ZL, 2014, AM J PHYSIOL-HEART C, V306, pH1087, DOI 10.1152/ajpheart.00052.2013
   Li ZL, 2011, AM J PHYSIOL-RENAL, V301, pF1078, DOI 10.1152/ajprenal.00333.2011
   Martins D, 2010, J NUTR METAB, V2010, DOI 10.1155/2010/167162
   McFarland R, 2007, CURR TOP DEV BIOL, V77, P113, DOI 10.1016/S0070-2153(06)77005-3
   Möllsten A, 2007, DIABETES, V56, P265, DOI 10.2337/db06-0698
   Nishio Y, 2004, ANN NY ACAD SCI, V1011, P78, DOI 10.1196/annals.1293.009
   Palacios R, 2006, ANTIVIR THER, V11, P529
   Parra V, 2014, DIABETES, V63, P75, DOI 10.2337/db13-0340
   Pawar AS, 2015, OBESITY, V23, P399, DOI 10.1002/oby.20971
   Persson MF, 2012, DIABETOLOGIA, V55, P1535, DOI 10.1007/s00125-012-2469-5
   PFALLER W, 1980, INT J BIOCHEM, V12, P17, DOI 10.1016/0020-711X(80)90035-X
   Pi JB, 2007, DIABETES, V56, P1783, DOI 10.2337/db06-1601
   Saha JK, 2005, EXP BIOL MED, V230, P777, DOI 10.1177/153537020523001012
   SANFORD TD, 1980, LAB ANIM SCI, V30, P519
   Schlame M, 2008, J LIPID RES, V49, P1607, DOI 10.1194/jlr.R700018-JLR200
   Shahzad K, 2015, KIDNEY INT, V87, P74, DOI 10.1038/ki.2014.271
   Szeto HH, 2016, KIDNEY INT, V90, P997, DOI 10.1016/j.kint.2016.06.013
   Szeto HH, 2015, AM J PHYSIOL-RENAL, V308, pF11, DOI 10.1152/ajprenal.00366.2014
   Szeto HH, 2014, BRIT J PHARMACOL, V171, P2029, DOI 10.1111/bph.12461
   Textor SC, 2012, AM J KIDNEY DIS, V59, P229, DOI 10.1053/j.ajkd.2011.09.023
   Thomas G, 2011, CLIN J AM SOC NEPHRO, V6, P2364, DOI 10.2215/CJN.02180311
   Tomaszewski M, 2007, KIDNEY INT, V71, P816, DOI 10.1038/sj.ki.5002160
   Urbieta-Caceres VH, 2012, ATHEROSCLEROSIS, V221, P350, DOI 10.1016/j.atherosclerosis.2011.10.005
   Vervoort G, 2005, EUR J CLIN INVEST, V35, P330, DOI 10.1111/j.1365-2362.2005.01497.x
   Wang C, 2013, FREE RADICAL BIO MED, V65, P1417, DOI 10.1016/j.freeradbiomed.2013.10.005
   Zhang H, 2011, J PINEAL RES, V51, P338, DOI 10.1111/j.1600-079X.2011.00894.x
   Zhang X, 2014, HYPERTENSION, V64, P87, DOI 10.1161/HYPERTENSIONAHA.113.02151
   Zhang X, 2013, AM J PHYSIOL-RENAL, V305, pF265, DOI 10.1152/ajprenal.00043.2013
NR 49
TC 30
Z9 33
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1931-5244
EI 1878-1810
J9 TRANSL RES
JI Transl. Res.
PD JUN
PY 2017
VL 184
BP 45
EP 56
DI 10.1016/j.trsl.2017.03.002
PG 12
WC Medical Laboratory Technology; Medicine, General & Internal; Medicine,
   Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology; General & Internal Medicine; Research &
   Experimental Medicine
GA EW1BH
UT WOS:000402224400005
PM 28363084
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Nair, AR
   Elks, CM
   Vila, J
   Del Piero, F
   Paulsen, DB
   Francis, J
AF Nair, Anand R.
   Elks, Carrie M.
   Vila, Jorge
   Del Piero, Fabio
   Paulsen, Daniel B.
   Francis, Joseph
TI A Blueberry-Enriched Diet Improves Renal Function and Reduces Oxidative
   Stress in Metabolic Syndrome Animals: Potential Mechanism of TLR4-MAPK
   Signaling Pathway
SO PLOS ONE
LA English
DT Article
ID CHRONIC KIDNEY-DISEASE; NF-KAPPA-B; MESSENGER-RNA EXPRESSION;
   TUBULOINTERSTITIAL INJURY; INSULIN-RESISTANCE; HYPERTENSIVE-RATS;
   ANGIOTENSIN-II; IN-VIVO; PROTEIN; OBESITY
AB Background: Metabolic syndrome (MetS) is characterized by a cluster of health factors that indicate a higher risk for cardiorenal diseases. Recent evidence indicates that antioxidants from berries are alternative to attenuate oxidative stress and inflammation. We tested the hypothesis that inflammation-induced renal damage is triggered by the activation of TLR4, and subsequent modulation of redox-sensitive molecules and mitogen-activated protein kinase (MAPK) pathway.
   Methods: Five-week old lean and obese Zucker rats (LZR and OZR) were fed a blueberry-enriched diet or an isocaloric control diet for 15 weeks. A glucose tolerance test and acute renal clearance experiments were performed. Gene and protein expression levels for TLR4, cytokines and phosphorylation of ERK and p38MAPK were measured. Kidney redox status and urinary albumin levels were quantified. Renal pathology was evaluated histologically.
   Results: Control OZR exhibited lower glucose tolerance; exacerbated renal function parameters; increased oxidative stress. Gene and protein expression levels of TLR4 were higher and this was accompanied by increased renal pathology with extensive albuminuria and deterioration in antioxidant levels in OZR. In addition, OZR had increased phosphorylation of ERK and p38MAPK. Blueberry-fed OZR exhibited significant improvements in all these parameters compared to OZR.
   Conclusion: TLR4-MAPK signaling pathway is a key to the renal structural injury and dysfunction in MetS and blueberry (BB) protect against this damage by inhibiting TLR4.
   Significance: This is the first study to put forth a potential mechanism of TLR4-induced kidney damage in a model of MetS and to elucidate a downstream mechanism by which blueberry exert their reno-protective effects.
C1 [Nair, Anand R.; Elks, Carrie M.; Vila, Jorge; Del Piero, Fabio; Paulsen, Daniel B.; Francis, Joseph] Louisiana State Univ, Sch Vet Med, Baton Rouge, LA 70803 USA.
   [Elks, Carrie M.] Pennington Biomed Res Ctr, Adipocyte Biol Lab, Baton Rouge, LA 70808 USA.
C3 Louisiana State University School of Veterinary Medicine; Louisiana
   State University System; Louisiana State University; Louisiana State
   University System; Louisiana State University; Pennington Biomedical
   Research Center
RP Francis, J (corresponding author), Louisiana State Univ, Sch Vet Med, Baton Rouge, LA 70803 USA.
EM jfrancis@vetmed.lsu.edu
RI Elks, Carrie/N-1961-2017; Francis, Joseph/I-4984-2012
OI Francis, Joseph/0000-0002-9502-4579
CR Adelman RD, 2001, J PEDIATR-US, V138, P481, DOI 10.1067/mpd.2001.113006
   Aksu U, 2011, CONTRIB NEPHROL, V174, P119, DOI 10.1159/000329249
   Bellezza Ilaria, 2010, Cancers (Basel), V2, P483, DOI 10.3390/cancers2020483
   Cai H, 2000, CIRC RES, V87, P840, DOI 10.1161/01.RES.87.10.840
   Cha JJ, 2013, ENDOCRINOLOGY, V154, P2144, DOI 10.1210/en.2012-2080
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Cui XL, 2006, FREE RADICAL BIO MED, V41, P213, DOI 10.1016/j.freeradbiomed.2006.02.004
   Eguchi K., 2014, Journal of atherosclerosis and thrombosis
   El-Atat FA, 2004, J AM SOC NEPHROL, V15, P2816, DOI 10.1097/01.ASN.0000133698.80390.37
   Elks CM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024028
   Elks CM, 2009, AM J PHYSIOL-RENAL, V296, pF298, DOI 10.1152/ajprenal.90628.2008
   Elks CM, 2013, BIOACTIVES FRUIT HLT, DOI [10.1002/9781118635551.ch11, DOI 10.1002/9781118635551.CH11]
   Ervin R Bethene, 2009, Natl Health Stat Report, P1
   Freeman LR, 2013, FREE RADICAL BIO MED, V56, P226, DOI 10.1016/j.freeradbiomed.2012.08.577
   Fukuyama N, 1997, FREE RADICAL BIO MED, V22, P771, DOI 10.1016/S0891-5849(96)00401-7
   Good DW, 2009, AM J PHYSIOL-RENAL, V297, pF866, DOI 10.1152/ajprenal.00335.2009
   Ha HJ, 1999, FREE RADICAL BIO MED, V26, P944, DOI 10.1016/S0891-5849(98)00276-7
   Hall AM, 2014, QJM-INT J MED, V107, P261, DOI 10.1093/qjmed/hct258
   Hardy OT, 2013, PEDIATR OBES, V8, pe19, DOI 10.1111/j.2047-6310.2012.00098.x
   Hisada Y, 1999, J CLIN INVEST, V103, P627, DOI 10.1172/JCI2454
   Itoh K, 2003, GENES CELLS, V8, P379, DOI 10.1046/j.1365-2443.2003.00640.x
   Johns BR, 2012, NEPHROL DIAL TRANSPL, V27, P1410, DOI 10.1093/ndt/gfr498
   Jung KJ, 2013, FREE RADICAL BIO MED, V61, P206, DOI 10.1016/j.freeradbiomed.2013.04.005
   Kambham N, 2001, KIDNEY INT, V59, P1498, DOI 10.1046/j.1523-1755.2001.0590041498.x
   Khoo Michael C K, 2013, IEEE Rev Biomed Eng, V6, P143, DOI 10.1109/RBME.2012.2232651
   Khoo NKH, 2012, FREE RADICAL BIO MED, V52, P2312, DOI 10.1016/j.freeradbiomed.2012.04.011
   Kim D, 2013, INT J MOL MED, V32, P1293, DOI 10.3892/ijmm.2013.1508
   Koc M, 2011, NEPHROL DIAL TRANSPL, V26, P955, DOI 10.1093/ndt/gfq500
   Leask A, 2004, FASEB J, V18, P816, DOI 10.1096/fj.03-1273rev
   Lepenies J, 2011, NEPHRON CLIN PRACT, V119, pC97, DOI 10.1159/000324765
   Long HD, 2013, J ENDOCRINOL INVEST, V36, P923, DOI 10.3275/8946
   Mariappan N, 2007, AM J PHYSIOL-HEART C, V293, pH2726, DOI 10.1152/ajpheart.00376.2007
   Medzhitov R, 1997, NATURE, V388, P394, DOI 10.1038/41131
   Medzhitov R, 1998, MOL CELL, V2, P253, DOI 10.1016/S1097-2765(00)80136-7
   Mogensen TH, 2009, CLIN MICROBIOL REV, V22, P240, DOI 10.1128/CMR.00046-08
   Moss NG, 2013, AM J PHYSIOL-RENAL, V305, pF830, DOI 10.1152/ajprenal.00048.2013
   Muzio M, 1998, J EXP MED, V187, P2097, DOI 10.1084/jem.187.12.2097
   Nair AR, 2014, FREE RADICAL BIO MED, V71, P16, DOI 10.1016/j.freeradbiomed.2014.03.012
   Nangaku M, 2006, J AM SOC NEPHROL, V17, P17, DOI 10.1681/ASN.2005070757
   Neri M, 2007, J CELL MOL MED, V11, P156, DOI 10.1111/j.1582-4934.2007.00009.x
   Pamidimukkala J, 2004, CLIN EXP HYPERTENS, V26, P55, DOI 10.1081/CEH-120027331
   Pedruzzi LM, 2012, BIOCHIMIE, V94, P2461, DOI 10.1016/j.biochi.2012.07.015
   Peng H, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0058339
   Peroval MY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0051243
   Polichnowski AJ, 2010, HYPERTENSION, V55, P1425, DOI 10.1161/HYPERTENSIONAHA.110.151332
   Queisser N, 2012, FREE RADICAL BIO MED, V53, P314, DOI 10.1016/j.freeradbiomed.2012.05.011
   Rodrigo R, 2002, FREE RADICAL BIO MED, V33, P409, DOI 10.1016/S0891-5849(02)00908-5
   Slyvka Y, 2009, ENDOCRINE, V35, P89, DOI 10.1007/s12020-008-9121-7
   Ta NN, 2010, ATHEROSCLEROSIS, V213, P429, DOI 10.1016/j.atherosclerosis.2010.08.064
   Tabet F, 2004, J CARDIOVASC PHARM, V44, P200, DOI 10.1097/00005344-200408000-00009
   Tan Y, 2011, DIABETES, V60, P625, DOI 10.2337/db10-1164
   Thobe BM, 2007, J CELL PHYSIOL, V210, P667, DOI 10.1002/jcp.20860
   Thomas G, 2011, CLIN J AM SOC NEPHRO, V6, P2364, DOI 10.2215/CJN.02180311
   Wahba IM, 2007, CLIN J AM SOC NEPHRO, V2, P550, DOI 10.2215/CJN.04071206
   Wang C, 2013, FREE RADICAL BIO MED, V65, P1417, DOI 10.1016/j.freeradbiomed.2013.10.005
   Wilson C.B., 2014, Behavioural brain research
   Wilson CB, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076146
   Xi LA, 2011, HEPATOLOGY, V53, P127, DOI 10.1002/hep.24011
   Xu XH, 2001, CIRCULATION, V104, P3103, DOI 10.1161/hc5001.100631
   Yang SM, 2014, FREE RADIC BIOL MED
   Youn J.Y., 2014, Diabetes
NR 61
TC 38
Z9 40
U1 0
U2 16
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 5
PY 2014
VL 9
IS 11
AR e111976
DI 10.1371/journal.pone.0111976
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AS9IQ
UT WOS:000344556900099
PM 25372283
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Monserrat-Mesquida, M
   Quetglas-Llabrés, M
   Bouzas, C
   Montemayor, S
   Mascaró, CM
   Casares, M
   Llompart, I
   Gámez, JM
   Tejada, S
   Martínez, JA
   Tur, JA
   Sureda, A
AF Monserrat-Mesquida, Margalida
   Quetglas-Llabres, Magdalena
   Bouzas, Cristina
   Montemayor, Sofia
   Mascaro, Catalina M.
   Casares, Miguel
   Llompart, Isabel
   Gamez, Jose M.
   Tejada, Silvia
   Alfredo Martinez, J.
   Tur, Josep A.
   Sureda, Antoni
TI A Greater Improvement of Intrahepatic Fat Contents after 6 Months of
   Lifestyle Intervention Is Related to a Better Oxidative Stress and
   Inflammatory Status in Non-Alcoholic Fatty Liver Disease
SO ANTIOXIDANTS
LA English
DT Article
DE NAFLD; IFC; aerobic capacity; oxidative stress; inflammation; biomarkers
ID METABOLIC SYNDROME; WEIGHT-LOSS; LONG-TERM; MEDITERRANEAN DIET; HEPATIC
   STEATOSIS; PHYSICAL-ACTIVITY; NAFLD; PATHOGENESIS; PROGRESSION;
   STEATOHEPATITIS
AB Non-alcoholic fatty liver disease (NAFLD) is a disorder characterized by the excessive accumulation of lipids in the liver parenchyma. To date, there is no effective pharmacological treatment against NAFLD. Objective: To assess the relationship between the improvement of the intrahepatic fat content (IFC) in patients with NAFLD and metabolic syndrome and biomarkers of oxidative stress and inflammation after 6 months of lifestyle intervention. Patients diagnosed with NAFLD (n = 60 adults; 40-60 years old) residing in the Balearic Islands, Spain, were distributed in tertiles attending the improvement of IFC calculated by magnetic resonance imaging (MRI). Anthropometrics, blood pressure, maximal oxygen uptake, and pro/antioxidant and inflammatory biomarkers were determined in plasma before and after the lifestyle intervention. The improvement in IFC levels was higher in tertile 3 with respect to tertiles 2 and 1. The greatest improvement in IFC is related to cardiorespiratory fitness and adherence to the Mediterranean diet (ADM). Higher reductions in weight, body mass index (BMI), and alanine aminotransferase (ALT) were observed in tertile 3 with respect to tertile 1 after 6 months of intervention. The improvement in catalase, irisin, and cytokeratin 18 plasma levels were higher in tertile 3, whereas no differences were observed in superoxide dismutase activity. Malondialdehyde and protein carbonyl levels, as biomarkers of oxidative damage, remained unchanged in all groups. The present data show that the reduction of IFC is associated with an improvement in pro/antioxidant and pro-inflammatory status and a better cardiorespiratory fitness in NAFLD patients.
C1 [Monserrat-Mesquida, Margalida; Quetglas-Llabres, Magdalena; Bouzas, Cristina; Montemayor, Sofia; Mascaro, Catalina M.; Llompart, Isabel; Gamez, Jose M.; Tejada, Silvia; Tur, Josep A.; Sureda, Antoni] Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.
   [Monserrat-Mesquida, Margalida; Quetglas-Llabres, Magdalena; Bouzas, Cristina; Llompart, Isabel; Gamez, Jose M.; Tejada, Silvia; Tur, Josep A.; Sureda, Antoni] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain.
   [Monserrat-Mesquida, Margalida; Bouzas, Cristina; Montemayor, Sofia; Mascaro, Catalina M.; Llompart, Isabel; Tejada, Silvia; Tur, Josep A.; Sureda, Antoni] Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain.
   [Casares, Miguel] Red Asistencial Juaneda, Radiodiag Serv, Palma De Mallorca 07011, Spain.
   [Llompart, Isabel] Univ Hosp Son Espases, Clin Anal Serv, Palma De Mallorca 07198, Spain.
   [Gamez, Jose M.] Univ Hosp Son Llatzer, Cardiol Serv, Palma De Mallorca 07010, Spain.
   [Tejada, Silvia] Univ Balearic Isl, Dept Biol, Lab Neurophysiol, Palma De Mallorca 07122, Spain.
   [Alfredo Martinez, J.] Inst Madrileno Estudios Avanzados Alimentac IMDEA, Cardiomet Precis Nutr Program, Madrid 28049, Spain.
C3 Institut Investigacio Sanitaria Illes Balears (IdISBa); CIBER - Centro
   de Investigacion Biomedica en Red; CIBEROBN; Hospital Universitari Son
   Espases; Hospital Universitari Son Llatzer; Universitat de les Illes
   Balears
RP Tur, JA (corresponding author), Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Tur, JA (corresponding author), Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain.; Tur, JA (corresponding author), Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain.
EM margalida.monserrat@uib.es; m.quetglas@uib.es; cristinabouzas@uib.es;
   sofiamf16@gmail.com; c.mascaro@uib.es; casaresmiguel@gmail.com;
   isabel.llompart@ssib.es; jmgamez@hsll.es; silvia.tejada@uib.es;
   jalfredo.martinez@imdea.org; pep.tur@uib.es; antoni.sureda@uib.es
RI Tur, Josep/AAE-5748-2020; Martínez, J./K-8709-2014; Sureda,
   Antoni/N-9588-2019; Mesquida, Margalida/AAB-4773-2019; Quetglas Llabrés,
   Maria/AAA-4412-2019; Tejada, Silvia/L-7297-2014; Bouzas,
   Cristina/AAE-2069-2019; Tur, Josep/F-5576-2014
OI , Antoni/0000-0001-8656-6838; Monserrat Mesquida,
   Margalida/0000-0002-8856-135X; Tur, Josep/0000-0002-6940-0761;
   Montemayor, Sofia/0000-0001-7833-2118; Bouzas Velasco,
   Cristina/0000-0002-1407-8461
FU Fundacio La Marato TV3 (Spain) [201630.10]; Instituto de Salud Carlos
   III through the Fondo de Investigacion para la Salud [CIBEROBN
   CB12/03/30038, CIBER OBN18PI03]; European Regional Development Fund;
   EU-COST Action [CA16112]; IDISBA Grant (FOLIUM); Spanish Ministry of
   Education; IDISBA grant; IDISBA Grant (PRIMUS); IDISBA Grant (SYNERGIA);
   IDISBA Grant (LIBERI)
FX Fundacio La Marato TV3 (Spain) project ref. 201630.10. Instituto de
   Salud Carlos III through the Fondo de Investigacion para la Salud
   (CIBEROBN CB12/03/30038 and Proyecto Intramural CIBER OBN18PI03), which
   are co-funded by the European Regional Development Fund. Other funding
   received: EU-COST Action CA16112 and IDISBA Grants (FOLIUM, PRIMUS,
   SYNERGIA, and LIBERI). M.Q.-L. was granted by IDISBA grant. C.M.M.
   received an FPU Ph.D. Grant from the Spanish Ministry of Education. The
   funding sponsors had no role in the design of the study, in the
   collection, analyses, or interpretation of the data; in the writing of
   the manuscript, or in the decision to publish the results.
CR Abbate M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020629
   Abenavoli L, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16173011
   Al-Dayyat HM, 2018, DIABETES METAB SYND, V12, P569, DOI 10.1016/j.dsx.2018.03.016
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alkhouri Naim, 2009, Expert Rev Gastroenterol Hepatol, V3, P445, DOI 10.1586/egh.09.32
   Altaf B, 2020, J PAK MED ASSOC, V70, P2128, DOI 10.47391/JPMA.689
   Alvarez-Alvarez I, 2019, REV ESP CARDIOL, V72, P925, DOI 10.1016/j.rec.2018.08.010
   [Anonymous], 1984, METHOD ENZYMOL
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Brouwers B, 2018, AM J PHYSIOL-ENDOC M, V314, pE165, DOI 10.1152/ajpendo.00266.2017
   Buckley JP, 2004, BRIT J SPORT MED, V38, P197, DOI 10.1136/bjsm.2003.005389
   Byers T, 2015, ENDOCR-RELAT CANCER, V22, pR125, DOI 10.1530/ERC-14-0580
   Carter-Kent C, 2008, AM J GASTROENTEROL, V103, P1036, DOI 10.1111/j.1572-0241.2007.01709.x
   Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI 10.1002/hep.29367
   Chen Z, 2020, FREE RADICAL BIO MED, V152, P116, DOI 10.1016/j.freeradbiomed.2020.02.025
   Berkovic MC, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.734859
   Dallio M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051679
   de la Iglesia R, 2014, BRIT J NUTR, V111, P643, DOI 10.1017/S0007114513002778
   EASL, 2016, OBESITY FACTS, V9, P65, DOI [10.1159/000443344, 10.1007/s00125-016-3902-y, 10.1016/j.jhep.2015.11.004]
   El-Din Sayed H Seif, 2014, J Egypt Soc Parasitol, V44, P295
   Estruch R, 2013, NEW ENGL J MED, V368, P1279, DOI 10.1056/NEJMoa1200303
   Fabbrini E, 2008, GASTROENTEROLOGY, V134, P424, DOI 10.1053/j.gastro.2007.11.038
   Farzanegi P, 2019, EUR J SPORT SCI, V19, P994, DOI 10.1080/17461391.2019.1571114
   Finck BN, 2018, DIABETES, V67, P2485, DOI 10.2337/dbi18-0024
   FLOHE L, 1984, METHOD ENZYMOL, V105, P93
   Friedman SL, 2018, NAT MED, V24, P908, DOI 10.1038/s41591-018-0104-9
   Gelli C, 2017, WORLD J GASTROENTERO, V23, P3150, DOI 10.3748/wjg.v23.i17.3150
   Greenberg I, 2009, J AM COLL NUTR, V28, P159, DOI 10.1080/07315724.2009.10719767
   Hajighasem A, 2019, ARCH PHYSIOL BIOCHEM, V125, P142, DOI 10.1080/13813455.2018.1441872
   Harrison SA, 2008, GUT, V57, P1441, DOI 10.1136/gut.2007.146019
   Heinecke JW, 1997, CURR OPIN LIPIDOL, V8, P268, DOI 10.1097/00041433-199710000-00005
   Houttu V, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.716783
   Hu J, 2020, GASTROENT RES PRACT, V2020, DOI 10.1155/2020/8818191
   Izquierdo MC, 2019, HYPERTENS RES, V42, P2021, DOI 10.1038/s41440-019-0316-5
   Kawanaka M, 2015, ANN HEPATOL, V14, P837, DOI 10.5604/16652681.1171767
   Kwak MS, 2018, KOREAN J INTERN MED, V33, P64, DOI 10.3904/kjim.2017.343
   Lazo M, 2010, DIABETES CARE, V33, P2156, DOI 10.2337/dc10-0856
   Liu ZQ, 2021, DIGEST LIVER DIS, V53, P1435, DOI 10.1016/j.dld.2021.07.009
   Ma XF, 2020, BMC GASTROENTEROL, V20, DOI 10.1186/s12876-020-1165-z
   Mardinoglu A, 2018, CELL METAB, V27, P559, DOI 10.1016/j.cmet.2018.01.005
   Masarone M, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/9547613
   Mascaró CM, 2022, NUTRIENTS, V14, DOI 10.3390/nu14091813
   Monserrat-Mesquida M, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9080759
   Montemayor S, 2022, NUTRIENTS, V14, DOI 10.3390/nu14112223
   Moore LL, 2005, ARCH INTERN MED, V165, P1298, DOI 10.1001/archinte.165.11.1298
   Musso G, 2011, ANN MED, V43, P617, DOI 10.3109/07853890.2010.518623
   Noureddin M, 2020, HEPATOLOGY, V71, P1940, DOI 10.1002/hep.30967
   Patterson RE, 2016, AM J PHYSIOL-ENDOC M, V310, pE484, DOI 10.1152/ajpendo.00492.2015
   Perakakis N, 2017, NAT REV ENDOCRINOL, V13, P324, DOI 10.1038/nrendo.2016.221
   Perdomo CM, 2019, NUTRIENTS, V11, DOI 10.3390/nu11030677
   Polyzos SA, 2018, ENDOCRINE, V59, P260, DOI 10.1007/s12020-017-1476-1
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   Reeder SB, 2010, MAGN RESON IMAGING C, V18, P337, DOI 10.1016/j.mric.2010.08.013
   Roeb E, 2015, Z GASTROENTEROL, V53, P668, DOI 10.1055/s-0035-1553193
   Romero-Gómez M, 2017, J HEPATOL, V67, P829, DOI 10.1016/j.jhep.2017.05.016
   Safarian M, 2019, DIABETES METAB SYND, V13, P989, DOI 10.1016/j.dsx.2019.01.005
   Salomone F, 2016, LIVER INT, V36, P5, DOI 10.1111/liv.12975
   Stine JG, 2021, DIGEST DIS SCI, V66, P3604, DOI 10.1007/s10620-020-06673-w
   Swiderska M, 2019, FREE RADICAL RES, V53, P841, DOI 10.1080/10715762.2019.1635691
   Than NN, 2015, CLIN MED, V15, P186, DOI 10.7861/clinmedicine.15-2-186
   U.S. Department of Health and Human Services U.S. Department of Agriculture, 2015, DIETRY GUIDLINES AME, V8th
   Ucar F, 2013, REDOX REP, V18, P127, DOI 10.1179/1351000213Y.0000000050
   Vanni E, 2010, DIGEST LIVER DIS, V42, P320, DOI 10.1016/j.dld.2010.01.016
   Westerbacka J, 2004, DIABETOLOGIA, V47, P1360, DOI 10.1007/s00125-004-1460-1
   Williams KH, 2013, ENDOCR REV, V34, P84, DOI 10.1210/er.2012-1009
   Wing R, 2013, NEW ENGL J MED, V369, P145, DOI 10.1056/NEJMoa1212914
   Worm N, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051316
   Ye Q, 2020, LANCET GASTROENTEROL, V5, P739, DOI 10.1016/S2468-1253(20)30077-7
   Younossi ZM, 2019, J HEPATOL, V70, P531, DOI 10.1016/j.jhep.2018.10.033
   Zulet MA, 2011, NUTR HOSP, V26, P16, DOI 10.3305/nh.2011.26.1.5050
NR 70
TC 9
Z9 9
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUL
PY 2022
VL 11
IS 7
AR 1266
DI 10.3390/antiox11071266
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 3L0KV
UT WOS:000834460700001
PM 35883758
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dludla, PV
   Nkambule, BB
   Nyambuya, TM
   Ziqubu, K
   Mabhida, SE
   Mxinwa, V
   Mokgalaboni, K
   Ndevahoma, F
   Hanser, S
   Mazibuko-Mbeje, SE
   Basson, AK
   Sabbatinelli, J
   Tiano, L
AF Dludla, Phiwayinkosi V. V.
   Nkambule, Bongani B. B.
   Nyambuya, Tawanda M. M.
   Ziqubu, Khanyisani
   Mabhida, Sihle E. E.
   Mxinwa, Vuyolwethu
   Mokgalaboni, Kabelo
   Ndevahoma, Fransina
   Hanser, Sidney
   Mazibuko-Mbeje, Sithandiwe E. E.
   Basson, Albertus K. K.
   Sabbatinelli, Jacopo
   Tiano, Luca
TI Vitamin C intake potentially lowers total cholesterol to improve
   endothelial function in diabetic patients at increased risk of
   cardiovascular disease: A systematic review of randomized controlled
   trials
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE vitamin C; dietary supplements; antioxidants; diabetes mellitus;
   metabolic syndrome; cardiovascular diseases
ID OXIDATIVE STRESS; ASCORBIC-ACID; DIETARY-SUPPLEMENTS; GLYCEMIC CONTROL;
   BLOOD-PRESSURE; INSULIN SENSITIVITY; MELLITUS; METAANALYSIS; EXERCISE;
   HEALTH
AB Background: Vitamin C is one of the most consumed dietary compounds and contains abundant antioxidant properties that could be essential in improving metabolic function. Thus, the current systematic review analyzed evidence on the beneficial effects of vitamin C intake on cardiovascular disease (CVD)-related outcomes in patients with diabetes or metabolic syndrome. Methods: To identify relevant randomized control trials (RCTs), a systematic search was run using prominent search engines like PubMed and Google Scholar, from beginning up to March 2022. The modified Black and Downs checklist was used to assess the quality of evidence. Results: Findings summarized in the current review favor the beneficial effects of vitamin C intake on improving basic metabolic parameters and lowering total cholesterol levels to reduce CVD-risk in subjects with type 2 diabetes or related metabolic diseases. Moreover, vitamin C intake could also reduce the predominant markers of inflammation and oxidative stress like C-reactive protein, interleukin-6, and malondialdehyde. Importantly, these positive outcomes were consistent with improved endothelial function or increased blood flow in these subjects. Predominantly effective doses were 1,000 mg/daily for 4 weeks up to 12 months. The included RCTs presented with the high quality of evidence. Conclusion: Clinical evidence on the beneficial effects of vitamin C intake or its impact on improving prominent markers of inflammation and oxidative stress in patients with diabetes is still limited. Thus, more RCTs are required to solidify these findings, which is essential to better manage diabetic patients at increased risk of developing CVD.
C1 [Dludla, Phiwayinkosi V. V.; Mabhida, Sihle E. E.] South African Med Res Council, Biomed Res & Innovat Platform, Tygerberg, South Africa.
   [Dludla, Phiwayinkosi V. V.; Basson, Albertus K. K.] Univ Zululand, Dept Biochem & Microbiol, Kwa Dlangezwa, South Africa.
   [Nkambule, Bongani B. B.; Mxinwa, Vuyolwethu; Mokgalaboni, Kabelo] Univ KwaZulu Natal, Sch Lab Med & Med Sci, Durban, South Africa.
   [Nyambuya, Tawanda M. M.; Ndevahoma, Fransina] Namibia Univ Sci & Technol, Dept Hlth Sci, Windhoek, Namibia.
   [Ziqubu, Khanyisani; Mazibuko-Mbeje, Sithandiwe E. E.] North West Univ, Dept Biochem, Mmabatho, South Africa.
   [Mokgalaboni, Kabelo] Univ South Africa, Dept Life & Consumer Sci, Florida Campus, Roodepoort, South Africa.
   [Hanser, Sidney] Univ Limpopo, Dept Physiol & Environm Hlth, Sovenga, South Africa.
   [Sabbatinelli, Jacopo] Polytech Univ Marche, Dept Clin & Mol Sci, Ancona, Italy.
   [Tiano, Luca] Polytech Univ Marche, Dept Life & Environm Sci, Ancona, Italy.
C3 South African Medical Research Council; University of Zululand;
   University of Kwazulu Natal; Namibia University of Science & Technology;
   North West University - South Africa; University of South Africa;
   University of Limpopo; Marche Polytechnic University; Marche Polytechnic
   University
RP Dludla, PV (corresponding author), South African Med Res Council, Biomed Res & Innovat Platform, Tygerberg, South Africa.; Dludla, PV (corresponding author), Univ Zululand, Dept Biochem & Microbiol, Kwa Dlangezwa, South Africa.
EM pdludla@mrc.ac.za
RI Nyambuya, Tawanda Maurice/GLU-4124-2022; Nkambule,
   Bongani/ABD-7943-2022; Mazibuko-Mbeje, Sithandiwe/HPG-1119-2023;
   Mokgalaboni, Kabelo/ACZ-1282-2022; Tiano, Luca/ABC-2341-2020;
   Sabbatinelli, Jacopo/U-1851-2018
OI Mokgalaboni, Kabelo/0000-0002-3224-7433; Sabbatinelli,
   Jacopo/0000-0001-9947-6778; Mabhida, Sihle/0000-0002-8388-132X;
   Nyambuya, Tawanda Maurice/0000-0002-3288-9524; Nkambule,
   Bongani/0000-0001-8846-1992
FU South African Medical Research Council (SAMRC); National Research
   Foundation [117829];  [141929]
FX This work was supported in part by baseline funding from the Biomedical
   Research and Innovation Platform of the South African Medical Research
   Council (SAMRC) and the National Research Foundation (Grant numbers:
   141929 and 117829).
CR Afkhami-Ardekani M, 2007, INDIAN J MED RES, V126, P471
   American Heart Association [AHA], 2022, CARDIOVASCULAR DIS D
   Amini L, 2021, PAIN RES MANAG, V2021, DOI 10.1155/2021/5529741
   Anderson RA, 2006, DIABETIC MED, V23, P258, DOI 10.1111/j.1464-5491.2005.01767.x
   Ansley DM, 2013, J PATHOL, V229, P232, DOI 10.1002/path.4113
   Ashor AW, 2017, EUR J CLIN NUTR, V71, P1371, DOI 10.1038/ejcn.2017.24
   Ashor AW, 2019, NUTR RES, V61, P1, DOI 10.1016/j.nutres.2018.08.005
   Ashor AW, 2014, ATHEROSCLEROSIS, V235, P9, DOI 10.1016/j.atherosclerosis.2014.04.004
   Aune D, 2017, INT J EPIDEMIOL, V46, P1029, DOI 10.1093/ije/dyw319
   Blekkenhorst LC, 2018, NUTRIENTS, V10, DOI 10.3390/nu10050595
   Boonthongkaew C, 2021, CHINESE J PHYSIOL, V64, P16, DOI 10.4103/cjp.cjp_95_20
   Boudina S, 2010, REV ENDOCR METAB DIS, V11, P31, DOI 10.1007/s11154-010-9131-7
   Calvano A, 2019, FOOD FUNCT, V10, P6227, DOI [10.1039/C9FO01426H, 10.1039/c9fo01426h]
   Chaudhury A, 2017, FRONT ENDOCRINOL, V8, DOI 10.3389/fendo.2017.00006
   Chen C, 2021, ASIA PAC J CLIN NUTR, V30, P715, DOI 10.6133/apjcn.202112_30(4).0018
   Chen H, 2006, AM J PHYSIOL-HEART C, V290, pH137, DOI 10.1152/ajpheart.00768.2005
   Darko D, 2002, CLIN SCI, V103, P339, DOI 10.1042/cs1030339
   Davison GW, 2008, DIABETOLOGIA, V51, P2049, DOI 10.1007/s00125-008-1101-1
   De Blasio MJ, 2015, FREE RADICAL BIO MED, V87, P137, DOI 10.1016/j.freeradbiomed.2015.04.028
   Derosa G, 2014, ARCH MED SCI, V10, P336, DOI 10.5114/aoms.2014.42587
   Dludla PV, 2021, CLIN NUTR ESPEN, V41, P77, DOI 10.1016/j.clnesp.2020.11.006
   Dludla PV, 2018, AM J CARDIOVASC DRUG, V18, P283, DOI 10.1007/s40256-018-0275-2
   Dludla PV, 2017, NUTR METAB, V14, DOI 10.1186/s12986-017-0200-8
   Downs SH, 1998, J EPIDEMIOL COMMUN H, V52, P377, DOI 10.1136/jech.52.6.377
   Einarson TR, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0728-6
   El Messaoudi S, 2011, CURR OPIN LIPIDOL, V22, P445, DOI 10.1097/MOL.0b013e32834ae1a7
   Ellulu MS, 2015, DRUG DES DEV THER, V9, P3405, DOI 10.2147/DDDT.S83144
   Gordon DS, 2020, TOP COMPANION ANIM M, V39, DOI 10.1016/j.tcam.2020.100432
   Gutierrez AD, 2013, ENDOCR PRACT, V19, P785, DOI 10.4158/EP12431.OR
   International Diabetes Federation (IDF), 2022, IDF Diabetes Atlas, V10th, DOI DOI 10.1016/S0140-6736(55)92135-8
   Jiang Z, 2022, EMBO J, V41, DOI 10.15252/embj.2020106825
   Johansen JS, 2005, CARDIOVASC DIABETOL, V4, DOI 10.1186/1475-2840-4-5
   Kahal H, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-61531-z
   Kawashima A, 2015, REPROD SCI, V22, P783, DOI 10.1177/1933719114561561
   KLEIN F, 1995, SCAND J CLIN LAB INV, V55, P53, DOI 10.3109/00365519509075378
   Kong MJ, 2021, BIOMED PHARMACOTHER, V133, DOI 10.1016/j.biopha.2020.110975
   Krajcovicova-Kudlackova M., 2004, Central European Journal of Public Health, V12, P46
   Lee DH, 2004, AM J CLIN NUTR, V80, P1194, DOI 10.1093/ajcn/80.5.1194
   Levine M, 1999, JAMA-J AM MED ASSOC, V281, P1415, DOI 10.1001/jama.281.15.1415
   Lopez-Moreno J, 2018, J GERONTOL A-BIOL, V73, P340, DOI 10.1093/gerona/glw214
   Lu Q, 2005, CLIN SCI, V108, P507, DOI 10.1042/CS20040291
   Mahmoud AM, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/5484138
   Mason SA, 2021, DIABETES CARE, V44, P618, DOI 10.2337/dc20-1893
   Mason SA, 2019, DIABETES OBES METAB, V21, P674, DOI 10.1111/dom.13571
   Mason SA, 2016, FREE RADICAL BIO MED, V93, P227, DOI 10.1016/j.freeradbiomed.2016.01.006
   MayerDavis EJ, 1997, PREV MED, V26, P277, DOI 10.1006/pmed.1997.0145
   Mazloom Zohreh, 2011, Pak J Biol Sci, V14, P900, DOI 10.3923/pjbs.2011.900.904
   McAuliffe AV, 1998, NEPHRON, V80, P277, DOI 10.1159/000045187
   Morel O, 2003, J THROMB HAEMOST, V1, P171, DOI 10.1046/j.1538-7836.2003.00010.x
   Morelli MB, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9121227
   Mullan BA, 2002, HYPERTENSION, V40, P804, DOI 10.1161/01.HYP.0000039961.13718.00
   Mullan BA, 2004, AM J PHYSIOL-HEART C, V287, pH1262, DOI 10.1152/ajpheart.00153.2003
   National Library of Medicine through National Centre for Biotechnology Information., 2022, VIT C DIAB
   Ng KW, 2012, CIRCULATION, V125, P721, DOI 10.1161/CIRCULATIONAHA.111.063784
   O'Connor Sean R, 2015, BMC Res Notes, V8, P224, DOI 10.1186/s13104-015-1181-1
   Özerkan D, 2021, BIOTECH HISTOCHEM, V96, P347, DOI 10.1080/10520295.2020.1795718
   Padayatty SJ, 2016, ORAL DIS, V22, P463, DOI 10.1111/odi.12446
   Pandey A, 2011, J PHARM BIOALLIED SC, V3, P504, DOI 10.4103/0975-7406.90103
   PAOLISSO G, 1995, J AM COLL NUTR, V14, P387
   Park EJ, 2015, BBA-MOL BASIS DIS, V1852, P1071, DOI 10.1016/j.bbadis.2015.01.014
   Pitsavos Christos, 2006, Review of Diabetic Studies, V3, P118, DOI 10.1900/RDS.2006.3.118
   Riccardi G, 2004, CLIN NUTR, V23, P447, DOI 10.1016/j.clnu.2004.02.006
   Ryan MJ, 2010, EXP GERONTOL, V45, P882, DOI 10.1016/j.exger.2010.08.002
   Sesso HD, 2008, JAMA-J AM MED ASSOC, V300, P2123, DOI 10.1001/jama.2008.600
   Skeie G, 2009, EUR J CLIN NUTR, V63, pS226, DOI 10.1038/ejcn.2009.83
   Soare A, 2014, AGING-US, V6, P149
   Song YQ, 2009, AM J CLIN NUTR, V90, P429, DOI 10.3945/ajcn.2009.27491
   Tapsell Linda C, 2006, Med J Aust, V185, pS1
   Tareke AA, 2021, DIABETOL METAB SYNDR, V13, DOI 10.1186/s13098-021-00640-9
   Tousoulis D, 2003, DIABETES CARE, V26, P2749, DOI 10.2337/diacare.26.10.2749
   Traber MG, 2011, FREE RADICAL BIO MED, V51, P1000, DOI 10.1016/j.freeradbiomed.2011.05.017
   Upritchard JE, 2000, DIABETES CARE, V23, P733, DOI 10.2337/diacare.23.6.733
   Wold LE, 2004, BIOCHEM BIOPH RES CO, V318, P1066, DOI 10.1016/j.bbrc.2004.04.138
   World Health Organization, 2020, TOP 10 CAUS DEATH
   World Health Organization [WHO], 2022, WHO MOD LISTS ESS ME
   Yeh GY, 2003, DIABETES CARE, V26, P1277, DOI 10.2337/diacare.26.4.1277
   Zheng J, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00472
   Zhu N, 2021, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.591337
NR 78
TC 20
Z9 20
U1 3
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD OCT 31
PY 2022
VL 9
AR 1011002
DI 10.3389/fnut.2022.1011002
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 6H4BS
UT WOS:000885387900001
PM 36386907
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Xu, ZQ
   Elrashidy, RA
   Li, B
   Liu, GM
AF Xu, Zhenqun
   Elrashidy, Rania A.
   Li, Bo
   Liu, Guiming
TI Oxidative Stress: A Putative Link Between Lower Urinary Tract Symptoms
   and Aging and Major Chronic Diseases
SO FRONTIERS IN MEDICINE
LA English
DT Review
DE lower urinary tract symptoms (LUTS); oxidative stress; aging; chronic
   diseases; bladder
ID BENIGN PROSTATIC HYPERPLASIA; BLADDER OUTLET OBSTRUCTION;
   QUALITY-OF-LIFE; METABOLIC SYNDROME; OVERACTIVE BLADDER;
   PARKINSONS-DISEASE; SLEEP-APNEA; ANTIOXIDANT ENZYMES; URETHRAL
   SPHINCTER; ALZHEIMERS-DISEASE
AB Aging and major chronic diseases are risk factors for lower urinary tract symptoms (LUTS). On the other hand, oxidative stress (OS) is one of the fundamental mechanisms of aging and the development of chronic diseases. Therefore, OS might be a candidate mechanism linking these two clinical entities. This article aims to summarize the studies on the prevalence of LUTS, the role of OS in aging and chronic diseases, and the potential mechanisms supporting the putative link. A comprehensive literature search was performed to identify recent reports investigating LUTS and OS in major chronic diseases. In addition, studies on the impact of OS on the lower urinary tract, including bladder, urethra, and prostate, were collected and summarized. Many studies showed LUTS are prevalent in aging and major chronic diseases, including obesity, metabolic syndrome, diabetes, cardiovascular disease, hypertension, obstructive sleep apnea, autoimmune diseases, Alzheimer's disease, and Parkinson's disease. At the same time, OS is a key component in the pathogenesis of those chronic diseases and conditions. Recent studies also provided evidence that exacerbated OS can cause functional and/or structural changes in the bladder, urethra, and prostate, leading to LUTS. The reviewed data support the concept that OS is involved in multiple risk factors-associated LUTS, although further studies are needed to confirm the causative relationship. The specific ROS/RNS and corresponding reactions/pathways involved in chronic diseases and associated LUTS should be identified in the future and could serve as therapeutic targets.
C1 [Xu, Zhenqun; Li, Bo; Liu, Guiming] Case Western Reserve Univ, Dept Surg, MetroHlth Med Ctr, Cleveland, OH 44106 USA.
   [Xu, Zhenqun; Li, Bo] China Med Univ, Shengjing Hosp, Dept Urol, Shenyang, Peoples R China.
   [Elrashidy, Rania A.] Zagazig Univ, Fac Pharm, Dept Biochem, Zagazig, Egypt.
C3 University System of Ohio; Case Western Reserve University; MetroHealth
   System; China Medical University; Egyptian Knowledge Bank (EKB); Zagazig
   University
RP Liu, GM (corresponding author), Case Western Reserve Univ, Dept Surg, MetroHlth Med Ctr, Cleveland, OH 44106 USA.
EM guiming.liu@case.edu
RI Elrashidy, Rania/HLW-2856-2023
OI Elrashidy, Rania/0000-0001-8383-8383
FU National Institutes of Health (NIH) NIDDK [R01-DK110567]
FX Funding GL was supported by the National Institutes of Health (NIH)
   NIDDK grant R01-DK110567.
CR Abolhassani N, 2017, MECH AGEING DEV, V161, P95, DOI 10.1016/j.mad.2016.05.005
   Abrams P, 2002, NEUROUROL URODYNAM, V21, P167, DOI 10.1002/nau.10052
   Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Aharony SM, 2017, CUAJ-CAN UROL ASSOC, V11, P61, DOI 10.5489/cuaj.4058
   Alexandre EC, 2018, EUR J PHARMACOL, V836, P25, DOI 10.1016/j.ejphar.2018.08.010
   Anatoliotakis N, 2013, CURR TOP MED CHEM, V13, P115, DOI 10.2174/1568026611313020004
   Aydin A, 2006, CLIN BIOCHEM, V39, P176, DOI 10.1016/j.clinbiochem.2005.11.018
   Ayik S, 2014, TURK J MED SCI, V44, P249, DOI 10.3906/sag-1210-20
   Azadzoi KM, 2007, J UROLOGY, V178, P710, DOI 10.1016/j.juro.2007.03.096
   Bang WJ, 2014, UROLOGY, V84, P670, DOI 10.1016/j.urology.2014.05.017
   Baradaran A, 2014, J RES MED SCI, V19, P358
   Benli E, 2016, TURK J MED SCI, V46, P1665, DOI 10.3906/sag-1507-148
   Bernell S, 2016, FRONT PUBLIC HEALTH, V4, DOI 10.3389/fpubh.2016.00159
   Beshay E, 2004, UROLOGY, V64, P1062, DOI 10.1016/j.urology.2004.06.021
   Birder LA, 2021, WORLD J UROL, V39, P2685, DOI 10.1007/s00345-020-03492-6
   Bouwman II, 2014, BMC FAM PRACT, V15, DOI 10.1186/1471-2296-15-9
   Bouwman II, 2015, WORLD J UROL, V33, P1911, DOI 10.1007/s00345-015-1560-1
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Burke JP, 2006, UROLOGY, V67, P22, DOI 10.1016/j.urology.2005.08.010
   Butterfield DA, 2019, NAT REV NEUROSCI, V20, P148, DOI 10.1038/s41583-019-0132-6
   Cakir OO, 2012, CURR UROL REP, V13, P407, DOI 10.1007/s11934-012-0281-x
   Camoes J, 2015, UROL INT, V95, P373, DOI 10.1159/000437336
   Campos-Sousa RN, 2003, ARQ NEURO-PSIQUIAT, V61, P359, DOI 10.1590/S0004-282X2003000300007
   Cao NL, 2019, INT NEUROUROL J, V23, P91, DOI 10.5213/inj.1938050.025
   Carlisle RE, 2016, J HYPERTENS, V34, P1556, DOI 10.1097/HJH.0000000000000943
   Carpagnano GE, 2003, CHEST, V124, P1386, DOI 10.1378/chest.124.4.1386
   Changolkar AK, 2005, J UROLOGY, V173, P309, DOI 10.1097/01.ju.0000141583.31183.7a
   Cheraghi M, 2019, REP BIOCHEM MOL BIOL, V8, P49
   Chong C, 2012, PROSTATE CANCER P D, V15, P273, DOI 10.1038/pcan.2011.69
   Chung SD, 2016, SLEEP BREATH, V20, P1203, DOI 10.1007/s11325-016-1336-x
   Cox L, 2016, CURR OPIN UROL, V26, P328, DOI 10.1097/MOU.0000000000000283
   Cui Hang, 2012, J Signal Transduct, V2012, P646354, DOI 10.1155/2012/646354
   Daneshgari F, 2017, AM J PHYSIOL-RENAL, V312, pF887, DOI 10.1152/ajprenal.00489.2016
   Denys MA, 2016, NEUROUROL URODYNAM, V35, P278, DOI 10.1002/nau.22765
   Dias V, 2013, J PARKINSON DIS, V3, P461, DOI 10.3233/JPD-130230
   Dikalova AE, 2010, CIRC RES, V107, P106, DOI 10.1161/CIRCRESAHA.109.214601
   Dragonieri S, 2020, MEDICINA-LITHUANIA, V56, DOI 10.3390/medicina56050208
   Ekin S, 2021, SLEEP BREATH, V25, P529, DOI 10.1007/s11325-020-02093-2
   Elahi MM, 2009, OXID MED CELL LONGEV, V2, P259, DOI 10.4161/oxim.2.5.9441
   Elrashidy RA, 2019, EXP MOL PATHOL, V111, DOI 10.1016/j.yexmp.2019.104304
   Elrashidy RA, 2019, AM J PHYSIOL-RENAL, V317, pF906, DOI 10.1152/ajprenal.00221.2019
   Fitzgerald MP, 2007, EUR UROL, V52, P407, DOI 10.1016/j.eururo.2007.03.014
   Fode M, 2016, EUR UROL, V70, P797, DOI 10.1016/j.eururo.2016.07.030
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gacci M, 2016, EUR UROL, V70, P788, DOI 10.1016/j.eururo.2016.07.007
   Gacci M, 2016, CURR UROL REP, V17, DOI 10.1007/s11934-016-0620-4
   Gacci M, 2015, BJU INT, V115, P24, DOI 10.1111/bju.12728
   Gal A, 2017, LUTS, V9, P15, DOI 10.1111/luts.12102
   Gandaglia G, 2013, BJU INT, V112, P432, DOI 10.1111/bju.12118
   Garcia-Garcia A, 2012, ANTIOXID REDOX SIGN, V17, P1764, DOI 10.1089/ars.2011.4501
   Gecit I, 2015, REDOX REP, V20, P163, DOI 10.1179/1351000214Y.0000000121
   Gella A, 2009, CELL ADHES MIGR, V3, P88, DOI 10.4161/cam.3.1.7402
   Gracia KC, 2017, J CLIN MED, V6, DOI 10.3390/jcm6020022
   Groutz A, 2017, NEUROUROL URODYNAM, V36, P636, DOI 10.1002/nau.22980
   Guan JZ, 2015, MOL CELL BIOCHEM, V400, P183, DOI 10.1007/s11010-014-2274-1
   Gutierrez-Lopez L, 2012, OBESITY FACTS, V5, P12, DOI 10.1159/000336526
   Guzelsoy M, 2014, UROL J, V11, P1447
   Haarala M, 2000, INT UROGYNECOL J PEL, V11, P84, DOI 10.1007/s001920050075
   Haidinger G, 2000, EUR UROL, V37, P413, DOI 10.1159/000020162
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Harlow BL, 2018, J WOMENS HEALTH, V27, P283, DOI 10.1089/jwh.2017.6566
   He Q, 2016, PROSTATE CANCER P D, V19, P7, DOI 10.1038/pcan.2015.43
   He QQ, 2016, PROSTATE, V76, P964, DOI 10.1002/pros.23185
   He QQ, 2014, AGING MALE, V17, P223, DOI 10.3109/13685538.2014.967671
   Hebert LE, 2013, NEUROLOGY, V80, P1778, DOI 10.1212/WNL.0b013e31828726f5
   Higgins P, 2012, CARDIOVASC THER, V30, P217, DOI 10.1111/j.1755-5922.2011.00277.x
   Ho CH, 2010, NEUROUROL URODYNAM, V29, P424, DOI 10.1002/nau.20727
   Hobson P, 2003, PARKINSONISM RELAT D, V10, P67, DOI 10.1016/j.parkreldis.2003.07.001
   Huang WJ, 2016, BIOMED REP, V4, P519, DOI 10.3892/br.2016.630
   Hwang EC, 2015, LUTS, V7, P32, DOI 10.1111/luts.12046
   Hwang Onyou, 2013, Exp Neurobiol, V22, P11, DOI 10.5607/en.2013.22.1.11
   Irer B, 2018, UROLOGY, V121, P86, DOI 10.1016/j.urology.2018.08.001
   Irwin DE, 2009, EUR UROL, V56, P14, DOI 10.1016/j.eururo.2009.02.026
   Ito H, 2012, LUTS, V4, P68, DOI 10.1111/j.1757-5672.2011.00115.x
   Jialal I, 2012, J CLIN ENDOCR METAB, V97, pE1844, DOI 10.1210/jc.2012-2498
   Jiang F, 2011, REDOX REP, V16, P223, DOI 10.1179/174329211X13049558293713
   Jiménez-Osorio AS, 2014, INT J MOL SCI, V15, P20290, DOI 10.3390/ijms151120290
   Jung HB, 2017, INT BRAZ J UROL, V43, P256, DOI [10.1590/S1677-5538.IBJU.2015.0664, 10.1590/s1677-5538.ibju.2015.0664]
   Kamat PK, 2016, MOL NEUROBIOL, V53, P648, DOI 10.1007/s12035-014-9053-6
   Kanika ND, 2011, BJU INT, V107, P1676, DOI 10.1111/j.1464-410X.2010.09655.x
   Kapoor S, 2013, INT J UROL, V20, P79, DOI 10.1111/j.1442-2042.2012.03220.x
   Kasapoglu M, 2001, EXP GERONTOL, V36, P209, DOI 10.1016/S0531-5565(00)00198-4
   Kennedy BK, 2014, CELL, V159, P708, DOI 10.1016/j.cell.2014.10.039
   Kim JH, 2017, SURG OBES RELAT DIS, V13, P836, DOI 10.1016/j.soard.2017.01.047
   Kim JH, 2016, SURG OBES RELAT DIS, V12, P1585, DOI 10.1016/j.soard.2016.04.027
   Kim JW, 2013, J UROLOGY, V189, P2371, DOI 10.1016/j.juro.2012.12.101
   Kim TH, 2014, INT NEUROUROL J, V18, P126, DOI 10.5213/inj.2014.18.3.126
   Kim-Howard X, 2014, HUM MOL GENET, V23, P1656, DOI 10.1093/hmg/ddt532
   Konior A, 2014, ANTIOXID REDOX SIGN, V20, P2794, DOI 10.1089/ars.2013.5607
   Kotur-Stevuljevic J, 2015, ATHEROSCLEROSIS, V241, P192, DOI 10.1016/j.atherosclerosis.2015.05.016
   Kozakiewicz M, 2019, CLIN INTERV AGING, V14, P763, DOI 10.2147/CIA.S201250
   Kracochansky M, 2012, INT BRAZ J UROL, V38, P277, DOI 10.1590/S1677-55382012000200017
   Kullisaar T, 2012, PROSTATE, V72, P977, DOI 10.1002/pros.21502
   Kupelian V, 2009, J UROLOGY, V181, P694, DOI 10.1016/j.juro.2008.10.039
   Kupelian V, 2006, ARCH INTERN MED, V166, P2381, DOI 10.1001/archinte.166.21.2381
   Kupelian V, 2015, J UROLOGY, V193, P581, DOI 10.1016/j.juro.2014.08.097
   Kupelian V, 2013, J UROLOGY, V189, pS107, DOI 10.1016/j.juro.2012.11.026
   Laakso JT, 2004, J HYPERTENS, V22, P1333, DOI 10.1097/01.hjh.0000125441.28861.9f
   Laursen JB, 2001, CIRCULATION, V103, P1282
   Lawrence JM, 2007, DIABETES CARE, V30, P2536, DOI 10.2337/dc07-0262
   Lee HY, 2017, AM J ALZHEIMERS DIS, V32, P51, DOI 10.1177/1533317516680900
   Lee RK, 2012, BJU INT, V110, P540, DOI 10.1111/j.1464-410X.2011.10819.x
   Lee YC, 2017, NEUROUROL URODYNAM, V36, P1503, DOI 10.1002/nau.23165
   Liguori I, 2018, CLIN INTERV AGING, V13, P757, DOI 10.2147/CIA.S158513
   Lin ATL, 2005, NEUROUROL URODYNAM, V24, P282, DOI 10.1002/nau.20109
   Lin WY, 2012, BJU INT, V110, P1208, DOI 10.1111/j.1464-410X.2012.11185.x
   Link CL, 2011, J UROLOGY, V185, P955, DOI 10.1016/j.juro.2010.10.048
   Lip GYH, 2002, J HUM HYPERTENS, V16, P333, DOI 10.1038/sj/jhh/1001386
   Liu GM, 2008, NEUROUROL URODYNAM, V27, P429, DOI 10.1002/nau.20543
   Liu GM, 2015, AM J PHYSIOL-CELL PH, V309, pC169, DOI 10.1152/ajpcell.00046.2015
   Liu GM, 2014, CHINESE MED J-PEKING, V127, P1357, DOI 10.3760/cma.j.issn.0366-6999.20132407
   Liu XL, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/4323198
   Lyons MM, 2020, RESPIROLOGY, V25, P690, DOI 10.1111/resp.13838
   Madan A, 2017, INT J NEUROSCI, V127, P1136, DOI 10.1080/00207454.2017.1327857
   Manna P, 2015, METAB SYNDR RELAT D, V13, P423, DOI 10.1089/met.2015.0095
   Mannikarottu AS, 2005, J UROLOGY, V174, P360, DOI 10.1097/01.ju.0000161602.18671.c7
   Manzanero S, 2013, NEUROCHEM INT, V62, P712, DOI 10.1016/j.neuint.2012.11.009
   Mariappan P, 2006, BJU INT, V98, P1264, DOI 10.1111/j.1464-410X.2006.06525.x
   Maserejian NN, 2014, J UROLOGY, V191, P107, DOI 10.1016/j.juro.2013.07.005
   Masuda H, 2008, BJU INT, V101, P775, DOI 10.1111/j.1464-410X.2007.07310.x
   Matsui T, 2012, INT J UROL, V19, P669, DOI 10.1111/j.1442-2042.2012.03000.x
   Matsumoto S, 2010, PHYTOTHER RES, V24, P301, DOI 10.1002/ptr.2909
   McDonald C, 2017, PARKINSONISM RELAT D, V35, P8, DOI 10.1016/j.parkreldis.2016.10.024
   Milanlioglu A, 2016, WIEN KLIN WOCHENSCHR, V128, P169, DOI 10.1007/s00508-015-0742-6
   Milsom I, 2009, CURR OPIN UROL, V19, P337, DOI 10.1097/MOU.0b013e32832b659d
   Minciullo PL, 2015, UROL INT, V94, P249, DOI 10.1159/000366210
   Miyazaki T, 2015, CIRC J, V79, P2632, DOI 10.1253/circj.CJ-15-0654
   Miyazato M, 2017, NEUROUROL URODYNAM, V36, P1890, DOI 10.1002/nau.23206
   Miyazato M, 2017, NEUROUROL URODYNAM, V36, P376, DOI 10.1002/nau.22936
   Mondul AM, 2014, J UROLOGY, V191, P715, DOI 10.1016/j.juro.2013.08.110
   Mongiu Anne K, 2009, Curr Urol Rep, V10, P247
   Montezano AC, 2012, ANN MED, V44, pS2, DOI 10.3109/07853890.2011.653393
   Morgan PE, 2009, FREE RADICAL RES, V43, P117, DOI 10.1080/10715760802623896
   Moriyarna Y, 2008, UROLOGY, V71, P1096, DOI 10.1016/j.urology.2008.02.038
   Na HR, 2015, ASIA-PAC PSYCHIAT, V7, P113, DOI 10.1111/appy.12007
   Nanetti L, 2011, EUR J CLIN INVEST, V41, P1318, DOI 10.1111/j.1365-2362.2011.02546.x
   Newsholme P, 2012, J ENDOCRINOL, V214, P11, DOI 10.1530/JOE-12-0072
   Ngai HY, 2017, ASIAN J UROL, V4, P164, DOI 10.1016/j.ajur.2017.05.001
   Nomiya M, 2013, BJU INT, V112, pE221, DOI 10.1111/j.1464-410X.2012.11746.x
   Nomiya M, 2012, NEUROUROL URODYNAM, V31, P185, DOI 10.1002/nau.21191
   Norheim KB, 2012, FREE RADICAL RES, V46, P141, DOI 10.3109/10715762.2011.645206
   Novakovic ZS, 2017, SCAND J UROL, V51, P470, DOI 10.1080/21681805.2017.1354912
   Ohl K, 2016, EXP NEUROL, V277, P58, DOI 10.1016/j.expneurol.2015.11.010
   Oliver JL, 2013, J UROLOGY, V190, P1511, DOI 10.1016/j.juro.2013.02.025
   Ostchega Yechiam, 2020, NCHS Data Brief, P1
   Osuga Y, 2013, GERIATR GERONTOL INT, V13, P1010, DOI 10.1111/ggi.12048
   Ozben S, 2014, EUR J CLIN INVEST, V44, P1045, DOI 10.1111/eci.12338
   Oztura I, 2006, SLEEP MED, V7, P362, DOI 10.1016/j.sleep.2005.10.004
   Pandey KB, 2010, CLIN BIOCHEM, V43, P508, DOI 10.1016/j.clinbiochem.2009.11.011
   Parsons JK, 2008, UROLOGY, V72, P318, DOI 10.1016/j.urology.2008.03.057
   Patel RS, 2016, CIRCULATION, V133, P361, DOI 10.1161/CIRCULATIONAHA.115.019790
   Pedro-Botet J, 2000, J HUM HYPERTENS, V14, P343, DOI 10.1038/sj.jhh.1001034
   Penson DF, 2011, J UROLOGY, V186, P2316, DOI 10.1016/j.juro.2011.07.067
   Silva RPE, 2019, LUPUS, V28, P27, DOI 10.1177/0961203318811605
   Phelan S, 2012, J UROLOGY, V187, P939, DOI 10.1016/j.juro.2011.10.139
   Plata M, 2017, ACTAS UROL ESP, V41, P522, DOI [10.1016/j.acuroe.2017.07.006, 10.1016/j.acuro.2016.12.009]
   Plata M, 2019, NEUROUROL URODYNAM, V38, P200, DOI 10.1002/nau.23828
   Poeckel D, 2010, CARDIOVASC RES, V86, P243, DOI 10.1093/cvr/cvq016
   Poprac P, 2017, TRENDS PHARMACOL SCI, V38, P592, DOI 10.1016/j.tips.2017.04.005
   Pöyhönen A, 2016, UROLOGY, V95, P164, DOI 10.1016/j.urology.2016.06.023
   Przydacz M, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-76846-0
   Raghupathi W, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15030431
   Raheem OA, 2014, UROL ANNALS, V6, P31, DOI 10.4103/0974-7796.127019
   Rajda C, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18020353
   Reddy PH, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8050488
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Robinson JP, 2013, J NEUROSCI NURS, V45, P382, DOI 10.1097/JNN.0b013e3182a3cf67
   Rochette L, 2014, BBA-GEN SUBJECTS, V1840, P2709, DOI 10.1016/j.bbagen.2014.05.017
   Rohrmann S, 2005, INT J OBESITY, V29, P310, DOI 10.1038/sj.ijo.0802881
   Rohrmann S, 2016, UROLOGY, V95, P158, DOI 10.1016/j.urology.2016.06.021
   Russo GI, 2018, BJU INT, V121, P799, DOI 10.1111/bju.14007
   Salehi B, 2018, BIOMEDICINES, V6, DOI 10.3390/biomedicines6030091
   Sarma Aruna V, 2009, Curr Urol Rep, V10, P267
   Savini I, 2013, INT J MOL SCI, V14, P10497, DOI 10.3390/ijms140510497
   Schulz R, 2000, AM J RESP CRIT CARE, V162, P566, DOI 10.1164/ajrccm.162.2.9908091
   Strzyz P, 2016, NAT REV MOL CELL BIO, V17, P536, DOI 10.1038/nrm.2016.108
   Sugaya K, 2003, INT J UROL, V10, P569, DOI 10.1046/j.1442-2042.2003.00707.x
   Tai HC, 2016, J DIABETES COMPLICAT, V30, P415, DOI 10.1016/j.jdiacomp.2016.01.002
   Takahashi O, 2012, J AM GERIATR SOC, V60, P2370, DOI 10.1111/jgs.12004
   Tam CA, 2017, UROLOGY, V105, P141, DOI 10.1016/j.urology.2017.03.040
   Taylor BC, 2006, UROLOGY, V68, P804, DOI 10.1016/j.urology.2006.04.019
   Tian YD, 2016, LUTS, V8, P91, DOI 10.1111/luts.12078
   Tibaek S, 2008, NEUROUROL URODYNAM, V27, P763, DOI 10.1002/nau.20605
   Tóthová L, 2019, SLEEP BREATH, V23, P857, DOI 10.1007/s11325-018-01777-0
   Vahabi B, 2017, NEUROUROL URODYNAM, V36, P854, DOI 10.1002/nau.23035
   Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
   Van den Eeden SK, 2013, BMC UROL, V13, DOI 10.1186/1471-2490-13-12
   Van Guilder GP, 2006, OBESITY, V14, P2127, DOI 10.1038/oby.2006.248
   Vaughan CP, 2013, J UROLOGY, V189, P1377, DOI 10.1016/j.juro.2012.10.058
   Vávrová L, 2013, OBESITY FACTS, V6, P39, DOI 10.1159/000348569
   Vedanayagam M, 2017, BMJ-BRIT MED J, V357, DOI 10.1136/bmj.j1493
   Vicari E, 2020, INT J MED SCI, V17, P1864, DOI 10.7150/ijms.44443
   Vignozzi L, 2016, NAT REV UROL, V13, P108, DOI 10.1038/nrurol.2015.301
   Vital P, 2016, PROSTATE, V76, P58, DOI 10.1002/pros.23100
   Wang MS, 2018, BIOMED RES INT, V2018, DOI 10.1155/2018/2925985
   Wehrberger C, 2011, UROLOGY, V78, P1063, DOI 10.1016/j.urology.2011.05.065
   Wei JT, 2005, J UROLOGY, V173, P1256, DOI 10.1097/01.ju.0000155709.37840.fe
   Wei ZX, 2018, FRONT MOL NEUROSCI, V11, DOI 10.3389/fnmol.2018.00236
   Weidling IW, 2020, EXP NEUROL, V330, DOI 10.1016/j.expneurol.2020.113321
   Wessells H, 2018, DIABETES CARE, V41, P2170, DOI 10.2337/dc18-0255
   Witte LP, 2018, NEUROUROL URODYNAM, V37, P354, DOI 10.1002/nau.23301
   Xiao N, 2013, J UROLOGY, V189, P1130, DOI 10.1016/j.juro.2012.08.222
   Yang H, 2011, CLIN CHEM LAB MED, V49, P1773, DOI 10.1515/CCLM.2011.250
   Yang ZG, 2007, J UROLOGY, V178, P2213, DOI 10.1016/j.juro.2007.06.042
   Yazdany T, 2020, FEMALE PELVIC MED RE, V26, P16, DOI 10.1097/SPV.0000000000000802
   Yeo L, 2012, INT UROL NEPHROL, V44, P415, DOI 10.1007/s11255-011-9969-y
   Yilmaz SD, 2016, J WOUND OSTOMY CONT, V43, P523, DOI 10.1097/WON.0000000000000259
   Yokoyama O, 2017, J UROLOGY, V197, P423, DOI 10.1016/j.juro.2016.08.087
   Yoshimura K, 2004, INT J UROL, V11, P282, DOI 10.1111/j.1442-2042.2004.00791.x
   Zamuner M, 2014, ADV UROL, V2014, DOI 10.1155/2014/203854
   Zecca C, 2016, EUR J NEUROL, V23, P1228, DOI 10.1111/ene.13010
   Zhang B, 2018, EXP THER MED, V15, P1053, DOI 10.3892/etm.2017.5499
   Zhang HQ, 2015, FREE RADICAL BIO MED, V88, P314, DOI 10.1016/j.freeradbiomed.2015.05.036
NR 213
TC 20
Z9 20
U1 1
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD MAR 10
PY 2022
VL 9
AR 812967
DI 10.3389/fmed.2022.812967
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 0F4GV
UT WOS:000777320300001
PM 35360727
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sanchez-Lozada, LG
   Andres-Hernando, A
   Garcia-Arroyo, FE
   Cicerchi, C
   Li, NX
   Kuwabara, M
   Roncal-Jimenez, CA
   Johnson, RJ
   Lanaspa, MA
AF Sanchez-Lozada, Laura G.
   Andres-Hernando, Ana
   Garcia-Arroyo, Fernando E.
   Cicerchi, Christina
   Li, Nanxing
   Kuwabara, Masanari
   Roncal-Jimenez, Carlos A.
   Johnson, Richard J.
   Lanaspa, Miguel A.
TI Uric acid activates aldose reductase and the polyol pathway for
   endogenous fructose and fat production causing development of fatty
   liver in rats
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
DE fructose; uric acid; metabolic syndrome; liver metabolism; fatty acid;
   aldose reductase; polyol pathway; sorbitol
ID TRANSCRIPTIONAL ACTIVATOR; CELL-PROLIFERATION; METABOLIC SYNDROME;
   HYPERTONIC STRESS; DIETARY FRUCTOSE; OXIDATIVE STRESS; EXPRESSION;
   DISEASE; CONSUMPTION; CHILDREN
AB Dietary, fructose-containing sugars have been strongly associated with the development of nonalcoholic fatty liver disease (NAFLD). Recent studies suggest that fructose also can be produced via the polyol pathway in the liver, where it may induce hepatic fat accumulation. Moreover, fructose metabolism yields uric acid, which is highly associated with NAFLD. Here, using biochemical assays, reporter gene expression, and confocal fluorescence microscopy, we investigated whether uric acid regulates aldose reductase, a key enzyme in the polyol pathway. We evaluated whether soluble uric acid regulates aldose reductase expression both in cultured hepatocytes (HepG2 cells) and in the liver of hyperuricemic rats and whether this stimulation is associated with endogenous fructose production and fat accumulation. Uric acid dose-dependently stimulated aldose reductase expression in the HepG2 cells, and this stimulation was associated with endogenous fructose production and triglyceride accumulation. This stimulatory mechanism was mediated by uric acid-induced oxidative stress and stimulation of the transcription factor nuclear factor of activated T cells 5 (NFAT5). Uric acid also amplified the effects of elevated glucose levels to stimulate hepatocyte triglyceride accumulation. Hyperuricemic rats exhibited elevated hepatic aldose reductase expression, endogenous fructose accumulation, and fat buildup that was significantly reduced by co-administration of the xanthine oxidase inhibitor allopurinol. These results suggest that uric acid generated during fructose metabolism may act as a positive feedback mechanism that stimulates endogenous fructose production by stimulating aldose reductase in the polyol pathway. Our findings suggest an amplifying mechanism whereby soft drinks rich in glucose and fructose can induce NAFLD.
C1 [Sanchez-Lozada, Laura G.; Garcia-Arroyo, Fernando E.] Inst Nacl Cardiol Ignacio Chavez, Lab Renal Physiopathol, Mexico City 14080, DF, Mexico.
   [Andres-Hernando, Ana; Cicerchi, Christina; Li, Nanxing; Kuwabara, Masanari; Roncal-Jimenez, Carlos A.; Johnson, Richard J.; Lanaspa, Miguel A.] Univ Colorado, Sch Med, Div Renal Dis & Hypertens, Aurora, CO 80045 USA.
C3 National Institute of Cardiology - Mexico; University of Colorado
   System; University of Colorado Anschutz Medical Campus
RP Lanaspa, MA (corresponding author), Univ Colorado, Sch Med, Div Renal Dis & Hypertens, Aurora, CO 80045 USA.
EM miguel.lanaspagarcia@ucdenver.edu
RI Sanchez-Lozada, Laura/AAS-2104-2021; Lanaspa, Miguel/AAO-4971-2020;
   Kuwabara, Masanari/O-9844-2017
OI Kuwabara, Masanari/0000-0002-6601-4347; Garcia Arroyo, Fernando
   Enrique/0000-0003-1545-9765; Sanchez-Lozada,
   Laura-Gabriela/0000-0003-0348-9617; Andres-Hernando,
   Ana/0000-0002-0676-0188; Lanaspa, Miguel/0000-0002-1163-1831
FU National Institutes of Health [NIDDK 1R01DK109408-01A1, NIDDK R01
   DK108859-01]
FX This work was supported by National Institutes of Health Grants NIDDK
   1R01DK109408-01A1 and NIDDK R01 DK108859-01. Some of the authors are
   members of Colorado Research Partners LLC, a start-up company developing
   inhibitors of fructose metabolism (M. A. L., A. A.-H., C. A. R.-J., R.
   J. J., and L. G. S.-L.). Dr. Johnson also has equity with a start-up
   company (XORT Therapeutics) developing novel xanthine oxidase
   inhibitors. The content is solely the responsibility of the authors and
   does not necessarily represent the official views of the National
   Institutes of Health.
CR Abdelmalek MF, 2012, HEPATOLOGY, V56, P952, DOI 10.1002/hep.25741
   Abdelmalek MF, 2010, HEPATOLOGY, V51, P1961, DOI 10.1002/hep.23535
   Abid A, 2009, J HEPATOL, V51, P918, DOI 10.1016/j.jhep.2009.05.033
   Ackerman Z, 2005, HYPERTENSION, V45, P1012, DOI 10.1161/01.HYP.0000164570.20420.67
   Al-attar R, 2017, PEERJ, V5, DOI 10.7717/peerj.2797
   AMES BN, 1981, P NATL ACAD SCI-BIOL, V78, P6858, DOI 10.1073/pnas.78.11.6858
   Andres-Hernando A, 2008, J BIOL CHEM, V283, P25082, DOI 10.1074/jbc.M802381200
   Brown KE, 2005, HISTOL HISTOPATHOL, V20, P429, DOI 10.14670/HH-20.429
   Choi YJ, 2014, LAB INVEST, V94, P1114, DOI 10.1038/labinvest.2014.98
   Collison KS, 2009, OBESITY, V17, P2003, DOI 10.1038/oby.2009.58
   Ferreira VSG, 2010, ARQ BRAS ENDOCRINOL, V54, P362, DOI 10.1590/S0004-27302010000400004
   García-Arroyo FE, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0202901
   Gersch C, 2009, NUCLEOS NUCLEOT NUCL, V28, P118, DOI 10.1080/15257770902736400
   Hodgkinson AD, 2001, KIDNEY INT, V60, P211, DOI 10.1046/j.1523-1755.2001.00788.x
   Huang ZY, 2017, CELL COMMUN SIGNAL, V15, DOI 10.1186/s12964-016-0158-6
   Imaram W, 2010, FREE RADICAL BIO MED, V49, P275, DOI 10.1016/j.freeradbiomed.2010.04.010
   Ishimoto T, 2012, P NATL ACAD SCI USA, V109, P4320, DOI 10.1073/pnas.1119908109
   Jensen T, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-30267-2
   Jensen T, 2018, J HEPATOL, V68, P1063, DOI 10.1016/j.jhep.2018.01.019
   Jin R, 2012, J CLIN ENDOCR METAB, V97, pE1088, DOI 10.1210/jc.2012-1370
   Kang DH, 2005, J AM SOC NEPHROL, V16, P3553, DOI 10.1681/ASN.2005050572
   Kang DH, 2002, J AM SOC NEPHROL, V13, P2888, DOI 10.1097/01.ASN.0000034910.58454.FD
   Kang DH, 2005, AM J NEPHROL, V25, P425, DOI 10.1159/000087713
   Kim NH, 2014, EUR J IMMUNOL, V44, P2721, DOI 10.1002/eji.201343669
   Kuwabara M, 2018, INT J CARDIOL, V261, P183, DOI 10.1016/j.ijcard.2018.03.045
   Lanaspa MA, 2008, P NATL ACAD SCI USA, V105, P15797, DOI 10.1073/pnas.0805761105
   Lanaspa MA, 2018, P NATL ACAD SCI USA, V115, P3138, DOI 10.1073/pnas.1713837115
   Lanaspa MA, 2014, J AM SOC NEPHROL, V25, P2526, DOI 10.1681/ASN.2013080901
   Lanaspa MA, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3434
   Lanaspa MA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048801
   Lanaspa MA, 2012, J BIOL CHEM, V287, P40732, DOI 10.1074/jbc.M112.399899
   Lanaspa MA, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0047948, 10.1371/journal.pone.0048801]
   Lanaspa MA, 2010, J BIOL CHEM, V285, P31694, DOI 10.1074/jbc.M109.093690
   Lee JW, 2010, GUT LIVER, V4, P378, DOI 10.5009/gnl.2010.4.3.378
   Li YM, 2009, J HEPATOL, V50, P1029, DOI 10.1016/j.jhep.2008.11.021
   Lim JS, 2010, NAT REV GASTRO HEPAT, V7, P251, DOI 10.1038/nrgastro.2010.41
   LIN LR, 1993, INVEST OPHTH VIS SCI, V34, P2352
   López-Rodríguez C, 2004, P NATL ACAD SCI USA, V101, P2392, DOI 10.1073/pnas.0308703100
   Maersk M, 2012, AM J CLIN NUTR, V95, P283, DOI 10.3945/ajcn.111.022533
   Mohandas R, 2014, EXP CELL RES, V326, P136, DOI 10.1016/j.yexcr.2014.05.025
   Mosca A, 2017, J HEPATOL, V66, P1031, DOI 10.1016/j.jhep.2016.12.025
   Na KY, 2003, J AM SOC NEPHROL, V14, P283, DOI 10.1097/01.ASN.0000045050.19544.B2
   Nakatsu Y, 2015, AM J PHYSIOL-GASTR L, V309, pG42, DOI 10.1152/ajpgi.00443.2014
   Nomura K, 2012, J NUTR BIOCHEM, V23, P203, DOI 10.1016/j.jnutbio.2011.09.006
   O'Connor T, 1999, BIOCHEM J, V343, P487, DOI 10.1042/0264-6021:3430487
   Ouyang X, 2008, J HEPATOL, V48, P993, DOI 10.1016/j.jhep.2008.02.011
   Paschos P, 2018, CURR VASC PHARMACOL, V16, P269, DOI 10.2174/1570161115666170621082237
   Petta S, 2011, ALIMENT PHARM THER, V34, P757, DOI 10.1111/j.1365-2036.2011.04788.x
   Qiu LX, 2012, EXP DIABETES RES, DOI 10.1155/2012/789730
   Rittner HL, 1999, J CLIN INVEST, V103, P1007, DOI 10.1172/JCI4711
   Ruepp B, 1996, P NATL ACAD SCI USA, V93, P8624, DOI 10.1073/pnas.93.16.8624
   Sánchez-Lozada LG, 2008, AM J PHYSIOL-RENAL, V295, pF1134, DOI 10.1152/ajprenal.00104.2008
   Sánchez-Lozada LG, 2012, NEPHRON EXP NEPHROL, V121, pE71, DOI 10.1159/000345509
   Sautin YY, 2007, AM J PHYSIOL-CELL PH, V293, pC584, DOI 10.1152/ajpcell.00600.2006
   Schwarz JM, 2017, GASTROENTEROLOGY, V153, P743, DOI 10.1053/j.gastro.2017.05.043
   Shah VO, 1997, J CLIN ENDOCR METAB, V82, P2294, DOI 10.1210/jc.82.7.2294
   Sirota JC, 2013, METABOLISM, V62, P392, DOI 10.1016/j.metabol.2012.08.013
   Sylvia S., 2016, 9 EUR GASTR C OCT 24
   Vos MB, 2012, J PEDIATR GASTR NUTR, V54, P90, DOI 10.1097/MPG.0b013e318229da1a
   Woo SK, 2002, PFLUG ARCH EUR J PHY, V444, P579, DOI 10.1007/s00424-002-0849-2
   Xu CF, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011578
   Yu MA, 2010, J HYPERTENS, V28, P1234, DOI 10.1097/HJH.0b013e328337da1d
   Zhou XM, 2005, AM J PHYSIOL-RENAL, V289, pF377, DOI 10.1152/ajprenal.00463.2004
NR 63
TC 83
Z9 93
U1 2
U2 44
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI ROCKVILLE
PA 11200 ROCKVILLE PIKE, SUITE 302, ROCKVILLE, MD, UNITED STATES
SN 0021-9258
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 15
PY 2019
VL 294
IS 11
BP 4272
EP 4281
DI 10.1074/jbc.RA118.006158
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA HP7FZ
UT WOS:000461854400036
PM 30651350
OA Green Published
DA 2025-06-11
ER

PT J
AU Papaccio, F
   Ottaviani, M
   Truglio, M
   D'Arino, A
   Caputo, S
   Pacifico, A
   Iacovelli, P
   Di Nardo, A
   Picardo, M
   Bellei, B
AF Papaccio, Federica
   Ottaviani, Monica
   Truglio, Mauro
   D'Arino, Andrea
   Caputo, Silvia
   Pacifico, Alessia
   Iacovelli, Paolo
   Di Nardo, Anna
   Picardo, Mauro
   Bellei, Barbara
TI Markers of Metabolic Abnormalities in Vitiligo Patients
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE vitiligo; comorbidities; metabolic syndrome; inflammation
ID POLYUNSATURATED FATTY-ACIDS; OXIDATIVE STRESS; SUPEROXIDE-DISMUTASE;
   INSULIN-RESISTANCE; SERUM; PATHOGENESIS; ASSOCIATION; PLASMA; IL-17;
   HOMOCYSTEINE
AB While vitiligo is primarily caused by melanocyte deficiency or dysfunction, recent studies have revealed a notable prevalence of metabolic syndrome (MetS) among patients with vitiligo. This suggests shared pathogenic features between the two conditions. Individuals with vitiligo often exhibit variations in triglyceride levels, cholesterol, and blood pressure, which are also affected in MetS. Given the similarities in their underlying mechanisms, genetic factors, pro-inflammatory signalling pathways, and increased oxidative stress, this study aims to highlight the common traits between vitiligo and metabolic systemic disorders. Serum analyses confirmed increased low-density lipoprotein (LDL) levels in patients with vitiligo, compared to physiological values. In addition, we reported significant decreases in folate and vitamin D (Vit D) levels. Oxidative stress is one of the underlying causes of the development of metabolic syndromes and is related to the advancement of skin diseases. This study found high levels of inflammatory cytokines, such as interleukin-6 (IL-6) and chemokine 10 (CXCL10), which are markers of inflammation and disease progression. The accumulation of insulin growth factor binding proteins 5 (IGFBP5) and advanced glycation end products (AGEs) entailed in atherosclerosis and diabetes onset, respectively, were also disclosed in vitiligo. In addition, the blood-associated activity of the antioxidant enzymes catalase (Cat) and superoxide dismutase (SOD) was impaired. Moreover, the plasma fatty acid (FAs) profile analysis showed an alteration in composition and specific estimated activities of FAs biosynthetic enzymes resembling MetS development, resulting in an imbalance towards pro-inflammatory n6-series FAs. These results revealed a systemic metabolic alteration in vitiligo patients that could be considered a new target for developing a more effective therapeutic approach.
C1 [Papaccio, Federica; Ottaviani, Monica; Caputo, Silvia; Di Nardo, Anna; Bellei, Barbara] IRCCS, Lab Cutaneous Physiopathol, I-00144 Rome, Italy.
   [Papaccio, Federica; Ottaviani, Monica; Caputo, Silvia; Di Nardo, Anna; Bellei, Barbara] IRCCS, San Gallicano Dermatol Inst, Integrated Ctr Metabol Res, I-00144 Rome, Italy.
   [Truglio, Mauro] IRCCS, San Gallicano Dermatol Inst, Microbiol & Virol, I-00144 Rome, Italy.
   [D'Arino, Andrea] IRCCS, San Gallicano Dermatol Inst, Oncol & Preventat Dermatol, I-00144 Rome, Italy.
   [Pacifico, Alessia; Iacovelli, Paolo] IRCCS, San Gallicano Dermatol Inst, Phototherapy Unit, Clin Dermatol, I-00144 Rome, Italy.
   [Picardo, Mauro] IDI IRCCS, Ist Dermopat Immacolata, I-00167 Rome, Italy.
C3 IRCCS Istituti Fisioterapici Ospitalieri (IFO); IRCCS San Gallicano
   Dermatological Institute (ISG); IRCCS Istituti Fisioterapici Ospitalieri
   (IFO); IRCCS San Gallicano Dermatological Institute (ISG); IRCCS
   Istituti Fisioterapici Ospitalieri (IFO); IRCCS San Gallicano
   Dermatological Institute (ISG); IRCCS Istituti Fisioterapici Ospitalieri
   (IFO); IRCCS San Gallicano Dermatological Institute (ISG); IRCCS
   Istituto Dermopatico dell'Immacolata (IDI)
RP Papaccio, F (corresponding author), IRCCS, Lab Cutaneous Physiopathol, I-00144 Rome, Italy.; Papaccio, F (corresponding author), IRCCS, San Gallicano Dermatol Inst, Integrated Ctr Metabol Res, I-00144 Rome, Italy.
EM federica.papaccio@ifo.it; monica.ottaviani@ifo.it
RI Papaccio, Federica/M-4127-2018; Truglio, Mauro/GWC-0198-2022; di nardo,
   anna/AAI-1629-2020; D'Arino, Andrea/AAB-2065-2021; Caputo,
   Silvia/Y-7341-2018; Ottaviani, Monica/J-3183-2016; Bellei,
   Barbara/K-5288-2016
OI D'Arino, Andrea/0000-0002-0669-1442; Di Nardo, Anna/0000-0002-5575-9968;
   Ottaviani, Monica/0000-0002-6613-2570; Truglio,
   Mauro/0000-0003-3046-3922; Bellei, Barbara/0000-0002-3883-5500
FU Italian Ministry of Health (Ricerca Corrente 2024) [2024]; Italian
   Ministry of Health
FX This research was supported by a grant from the Italian Ministry of
   Health (Ricerca Corrente 2024).
CR Abdallah M, 2018, PIGM CELL MELANOMA R, V31, DOI 10.1111/pcmr.12667
   Abdelmagid SA, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0116195
   Abou Elela M, 2013, EUR J DERMATOL, V23, P350, DOI 10.1684/ejd.2013.2023
   Acharya P, 2020, AUSTRALAS J DERMATOL, V61, pE208, DOI 10.1111/ajd.13233
   Afkhami-Ardekani M, 2014, INT J DERMATOL, V53, P956, DOI 10.1111/ijd.12148
   Agarwal K, 2023, INDIAN J DERMATOL, V68, P274, DOI 10.4103/ijd.ijd_418_23
   Al-Shobaili HA, 2011, INT J HEALTH SCI-IJH, V5, P167
   Albracht-Schulte K, 2018, J NUTR BIOCHEM, V58, P1, DOI 10.1016/j.jnutbio.2018.02.012
   Atas H, 2017, BALK MED J, V34, P219, DOI 10.4274/balkanmedj.2016.1005
   Atas H, 2015, J PHOTOCH PHOTOBIO B, V148, P174, DOI 10.1016/j.jphotobiol.2015.04.005
   Bassiouny DA, 2011, CLIN EXP DERMATOL, V36, P292, DOI 10.1111/j.1365-2230.2010.03972.x
   Bellei B, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059782
   Bergqvist C, 2021, J DERMATOL, V48, P252, DOI 10.1111/1346-8138.15743
   Bhatti JS, 2017, BBA-MOL BASIS DIS, V1863, P1066, DOI 10.1016/j.bbadis.2016.11.010
   Bickers DR, 2006, J INVEST DERMATOL, V126, P2565, DOI 10.1038/sj.jid.5700340
   Calder PC, 2002, EUR J CLIN NUTR, V56, pS14, DOI 10.1038/sj.ejcn.1601478
   Calder PC, 2006, PROSTAG LEUKOTR ESS, V75, P197, DOI 10.1016/j.plefa.2006.05.012
   Carillon J, 2013, PHARM RES-DORDR, V30, P2718, DOI 10.1007/s11095-013-1113-5
   Chang HC, 2019, J AM ACAD DERMATOL, V81, P1442, DOI 10.1016/j.jaad.2019.06.022
   Chang WL, 2023, CELLS-BASEL, V12, DOI 10.3390/cells12060936
   Chiu HH, 2020, J FOOD DRUG ANAL, V28, P60, DOI 10.1016/j.jfda.2019.10.003
   D'Arino A, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22168820
   Dell'Anna ML, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-13961-5
   Dell'Anna ML, 2003, PIGM CELL RES, V16, P553, DOI 10.1034/j.1600-0749.2003.00087.x
   Denisenko YK, 2020, J OBES, V2020, DOI 10.1155/2020/5762395
   Esmaeili B, 2011, IRAN J ALLERGY ASTHM, V10, P81, DOI 010.02/ijaai.8189
   Ezzedine K, 2012, PIGM CELL MELANOMA R, V25, pE1, DOI 10.1111/j.1755-148X.2012.00997.x
   Ezzedine K, 2015, LANCET, V386, P74, DOI 10.1016/S0140-6736(14)60763-7
   Fischer F, 2004, CLIN ENDOCRINOL, V61, P595, DOI 10.1111/j.1365-2265.2004.02136.x
   Frisoli ML, 2020, ANNU REV IMMUNOL, V38, P621, DOI 10.1146/annurev-immunol-100919-023531
   Gilroy DW, 2019, BRIT J PHARMACOL, V176, P1009, DOI 10.1111/bph.14587
   Gisondi P, 2018, CLIN DERMATOL, V36, P21, DOI 10.1016/j.clindermatol.2017.09.005
   Gopal K V T, 2014, Indian Dermatol Online J, V5, P456, DOI 10.4103/2229-5178.142493
   HALLIWELL B, 1995, CRIT REV FOOD SCI, V35, P7, DOI 10.1080/10408399509527682
   Hao Y, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.711060
   Hasibuan Dina R U, 2017, Open Access Maced J Med Sci, V5, P332, DOI 10.3889/oamjms.2017.066
   Hu ZH, 2023, FRONT MED-LAUSANNE, V10, DOI 10.3389/fmed.2023.1072837
   Jain A, 2011, INDIAN J CLIN BIOCHE, V26, P78, DOI 10.1007/s12291-010-0045-7
   Karadag AS, 2011, ACTA DERM-VENEREOL, V91, P541, DOI 10.2340/00015555-1141
   Kassab A, 2023, J CLIN MED, V12, DOI 10.3390/jcm12185861
   Katz EL, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.624517
   Khalid M, 2022, BIOMOLECULES, V12, DOI 10.3390/biom12040542
   Khan R, 2012, J AM ACAD DERMATOL, V66, P510, DOI 10.1016/j.jaad.2011.07.018
   Khan R, 2009, ARCH DERMATOL RES, V301, P731, DOI 10.1007/s00403-009-0964-4
   Koca R, 2004, CLIN EXP DERMATOL, V29, P406, DOI 10.1111/j.1365-2230.2004.01524.x
   Kovacs D, 2018, J INVEST DERMATOL, V138, P394, DOI 10.1016/j.jid.2017.06.033
   Le TVT, 2021, DERMAT RES PRACT, V2021, DOI 10.1155/2021/5524566
   Lee J, 2022, NUTRIENTS, V14, DOI 10.3390/nu14153086
   Lepoittevin M, 2023, CELL MOL BIOL LETT, V28, DOI 10.1186/s11658-023-00452-x
   Lepretti M, 2018, NUTRIENTS, V10, DOI 10.3390/nu10030350
   Lyu C, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.1055958
   Marchioro HZ, 2022, AN BRAS DERMATOL, V97, P478, DOI 10.1016/j.abd.2021.09.008
   Mascarenhas MRM, 2024, AN BRAS DERMATOL, V99, P196, DOI 10.1016/j.abd.2023.03.007
   Mason P J, 1997, Medsurg Nurs, V6, P216
   Mathachan SR, 2021, J COSMET DERMATOL-US, V20, P352, DOI 10.1111/jocd.13499
   Mayneris-Perxachs J, 2014, CLIN NUTR, V33, P90, DOI 10.1016/j.clnu.2013.03.001
   Moretti S, 2002, PIGM CELL RES, V15, P87, DOI 10.1034/j.1600-0749.2002.1o049.x
   Namazi N, 2021, DERMATOL THER, V34, DOI 10.1111/dth.14803
   Nigam A, 2009, NUTR METAB CARDIOVAS, V19, P264, DOI 10.1016/j.numecd.2008.07.008
   Osman AM, 2015, INDIAN J DERMATOL, V60, DOI 10.4103/0019-5154.169136
   Page S, 2011, OBES REV, V12, pe21, DOI 10.1111/j.1467-789X.2010.00773.x
   Papaccio F, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11223583
   Parwani K, 2023, ARCH PHYSIOL BIOCHEM, V129, P95, DOI 10.1080/13813455.2020.1797106
   Picardo M, 2015, NAT REV DIS PRIMERS, V1, DOI 10.1038/nrdp.2015.11
   Pietrzak A, 2012, DERMATOL THER, V25, pS41, DOI 10.1111/dth.12012
   Planas A, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23116234
   Rahman I, 2006, EUR J PHARMACOL, V533, P222, DOI 10.1016/j.ejphar.2005.12.087
   Randhawa M, 2009, FASEB J, V23, P835, DOI 10.1096/fj.08-116327
   Raveendra L, 2017, INDIAN J DERMATOL, V62, P168, DOI 10.4103/ijd.IJD_360_16
   Rehman K, 2016, J BIOMED SCI, V23, DOI 10.1186/s12929-016-0303-y
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Salama AH, 2023, CUREUS J MED SCIENCE, V15, DOI 10.7759/cureus.45030
   Samson SL, 2014, ENDOCRIN METAB CLIN, V43, P1, DOI 10.1016/j.ecl.2013.09.009
   Serhan CN, 2018, MOL ASPECTS MED, V64, P1, DOI 10.1016/j.mam.2017.08.002
   Shen CB, 2016, FRONT GENET, V7, DOI 10.3389/fgene.2016.00003
   Shi MH, 2017, CLIN EXP DERMATOL, V42, P21, DOI 10.1111/ced.12950
   Simopoulos AP, 1999, AM J CLIN NUTR, V70, p560S, DOI 10.1093/ajcn/70.3.560s
   Singh RK, 2016, AUTOIMMUN REV, V15, P397, DOI 10.1016/j.autrev.2016.01.004
   Singh S, 2011, J CLIN LAB ANAL, V25, P110, DOI 10.1002/jcla.20442
   Singh VP, 2014, KOREAN J PHYSIOL PHA, V18, P1, DOI 10.4196/kjpp.2014.18.1.1
   Speeckaert R, 2017, AM J CLIN DERMATOL, V18, P733, DOI 10.1007/s40257-017-0298-5
   Sravani PV, 2009, INDIAN J DERMATOL VE, V75, P268, DOI 10.4103/0378-6323.48427
   Tanacan E, 2020, AN BRAS DERMATOL, V95, P165, DOI 10.1016/j.abd.2019.07.006
   Tsai TY, 2019, J AM ACAD DERMATOL, V80, P646, DOI 10.1016/j.jaad.2018.08.029
   Turkcu UO, 2014, GENE, V536, P129, DOI 10.1016/j.gene.2013.11.055
   Vaccaro M, 2017, ARCH DERMATOL RES, V309, P485, DOI 10.1007/s00403-017-1746-z
   Xia Joyce, 2022, JMIR Dermatol, V5, pe34772, DOI 10.2196/34772
   Zhang XJ, 2005, J DERMATOL SCI, V39, P137, DOI 10.1016/j.jdermsci.2005.06.004
   Zhu Y, 2015, AGING CELL, V14, P644, DOI 10.1111/acel.12344
NR 89
TC 6
Z9 6
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP
PY 2024
VL 25
IS 18
AR 10201
DI 10.3390/ijms251810201
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA H5E7Y
UT WOS:001323679100001
PM 39337683
OA gold
DA 2025-06-11
ER

PT J
AU Patel, TP
   Rawal, K
   Bagchi, AK
   Akolkar, G
   Bernardes, N
   Dias, DD
   Gupta, S
   Singal, PK
AF Patel, Tushar P.
   Rawal, Komal
   Bagchi, Ashim K.
   Akolkar, Gauri
   Bernardes, Nathalia
   Dias, Danielle da Silva
   Gupta, Sarita
   Singal, Pawan K.
TI Insulin resistance: an additional risk factor in the pathogenesis of
   cardiovascular disease in type 2 diabetes
SO HEART FAILURE REVIEWS
LA English
DT Article
DE Insulin resistance; CVD; Dyslipidemia; Metabolic syndrome; Oxidative
   stress; Inflammation
ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; MITOCHONDRIAL SUPEROXIDE-PRODUCTION;
   CARDIAC AUTONOMIC NEUROPATHY; NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS;
   ENDOTHELIAL DYSFUNCTION; ADIPOSE-TISSUE; ANGIOTENSIN-II; POTENTIAL ROLE;
   GENE-EXPRESSION
AB Sedentary life style and high calorie dietary habits are prominent leading cause of metabolic syndrome in modern world. Obesity plays a central role in occurrence of various diseases like hyperinsulinemia, hyperglycemia and hyperlipidemia, which lead to insulin resistance and metabolic derangements like cardiovascular diseases (CVDs) mediated by oxidative stress. The mortality rate due to CVDs is on the rise in developing countries. Insulin resistance (IR) leads to micro or macro angiopathy, peripheral arterial dysfunction, hampered blood flow, hypertension, as well as the cardiomyocyte and the endothelial cell dysfunctions, thus increasing risk factors for coronary artery blockage, stroke and heart failure suggesting that there is a strong association between IR and CVDs. The plausible linkages between these two pathophysiological conditions are altered levels of insulin signaling proteins such as IR-beta, IRS-1, PI3K, Akt, Glut4 and PGC-1 alpha that hamper insulin-mediated glucose uptake as well as other functions of insulin in the cardiomyocytes and the endothelial cells of the heart. Reduced AMPK, PFK-2 and elevated levels of NADP(H)-dependent oxidases produced by activated M1 macrophages of the adipose tissue and elevated levels of circulating angiotensin are also cause of CVD in diabetes mellitus condition. Insulin sensitizers, angiotensin blockers, superoxide scavengers are used as therapeutics in the amelioration of CVD. It evidently becomes important to unravel the mechanisms of the association between IR and CVDs in order to formulate novel efficient drugs to treat patients suffering from insulin resistance-mediated cardiovascular diseases. The possible associations between insulin resistance and cardiovascular diseases are reviewed here.
C1 [Patel, Tushar P.; Rawal, Komal; Gupta, Sarita] Maharaja Sayajirao Univ Baroda, Fac Sci, Dept Biochem, Mol Endocrinol & Stem Cell Res Lab, Vadodara 390002, Gujarat, India.
   [Bagchi, Ashim K.; Akolkar, Gauri; Bernardes, Nathalia; Dias, Danielle da Silva; Singal, Pawan K.] Univ Manitoba, Inst Cardiovasc Sci, St Boniface Res Ctr, Dept Physiol & Pathophysiol,Fac Hlth Sci, Winnipeg, MB R2H 2A6, Canada.
C3 Maharaja Sayajirao University Baroda; University of Manitoba; Saint
   Boniface Hospital; Children's Hospital Research Institute of Manitoba
RP Gupta, S (corresponding author), Maharaja Sayajirao Univ Baroda, Fac Sci, Dept Biochem, Mol Endocrinol & Stem Cell Res Lab, Vadodara 390002, Gujarat, India.
EM sglmescrl@gmail.com
RI da Silva Dias, Danielle/AAN-7618-2020; Patel, Tushar/AFL-3979-2022;
   Bagchi, Ashim/AAY-8074-2020; Bernardes, Nathalia/L-7460-2015; Patel,
   Tushar P/G-4006-2013
OI Patel, Tushar P/0000-0002-7823-2579
FU St. Boniface Hospital and Research Foundation
FX Prof. Sarita Gupta was a visiting scientist in Institute of
   Cardiovascular Sciences. Nathalia Bernardes and Danielle da Silva Dias
   were exchange students, under the Canada-Brazil Training program. Dr.
   Pawan Singal is the holder of the Dr. Naranjan S. Dhalla Chair in
   Cardiovascular Research supported by St. Boniface Hospital and Research
   Foundation.
CR [Anonymous], 1993, DIABETES CARE, V16, P1394
   Astrup AS, 2006, DIABETES CARE, V29, P334, DOI 10.2337/diacare.29.02.06.dc05-1242
   Bertrand L, 2008, CARDIOVASC RES, V79, P238, DOI 10.1093/cvr/cvn093
   Borén J, 2013, J INTERN MED, V274, P25, DOI 10.1111/joim.12071
   Brown NJ, 2000, J CLIN ENDOCR METAB, V85, P336, DOI 10.1210/jc.85.1.336
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Bugianesi E, 2005, HEPATOLOGY, V42, P987, DOI 10.1002/hep.20920
   Bugiardini R, 2004, CIRCULATION, V109, P2518, DOI 10.1161/01.CIR.0000128208.22378.E3
   Calles-Escandon J, 1998, DIABETES, V47, P290, DOI 10.2337/diabetes.47.2.290
   CASTELLO A, 1994, J BIOL CHEM, V269, P5905
   Ceriello A, 2003, DIABETES CARE, V26, P1589, DOI 10.2337/diacare.26.5.1589
   Ceriello A, 2005, DIABETES, V54, P1, DOI 10.2337/diabetes.54.1.1
   Chen H, 2003, J BIOL CHEM, V278, P45021, DOI 10.1074/jbc.M307878200
   Chen YQ, 1998, J BIOL CHEM, V273, P8225, DOI 10.1074/jbc.273.14.8225
   De Marchi E, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/564961
   DeFronzo RA, 2009, DIABETES CARE, V32, pS157, DOI 10.2337/dc09-S302
   Desouza CV, 2010, DIABETES CARE, V33, P1389, DOI 10.2337/dc09-2082
   Després JP, 2006, EUR HEART J SUPPL, V8, pB4, DOI 10.1093/eurheartj/sul002
   Despres JP, 1996, NEW ENGL J MED, V334, P952, DOI 10.1056/NEJM199604113341504
   Dimmeler S, 1999, NATURE, V399, P601, DOI 10.1038/21224
   Dong F, 2007, DIABETES, V56, P2201, DOI 10.2337/db06-1596
   Dröge W, 2002, PHYSIOL REV, V82, P47, DOI 10.1152/physrev.00018.2001
   Duncan BB, 2003, DIABETES, V52, P1799, DOI 10.2337/diabetes.52.7.1799
   El-Osta A, 2008, J EXP MED, V205, P2409, DOI 10.1084/jem.20081188
   Eriksson P, 1998, ARTERIOSCL THROM VAS, V18, P20, DOI 10.1161/01.ATV.18.1.20
   Farahmand F., 2003, Atherosclerosis, hypertension, and diabetes, P427, DOI [10.1007/978-1-4419-9232-1_32, DOI 10.1007/978-1-4419-9232-1_32.]
   Fowler MJ., 2008, CLIN DIABETES, V26, P77, DOI DOI 10.2337/DIACLIN.26.2.77
   Frier BM, 2011, DIABETES CARE, V34, pS132, DOI 10.2337/dc11-s220
   Garcia M, 1972, ADV METAB DISORD S2, V2, P493
   Garcia-Roves P, 2007, P NATL ACAD SCI USA, V104, P10709, DOI 10.1073/pnas.0704024104
   Garnier A, 2003, J PHYSIOL-LONDON, V551, P491, DOI 10.1113/jphysiol.2003.045104
   Ginsberg HN, 2000, J CLIN INVEST, V106, P453, DOI 10.1172/JCI10762
   GOLAY A, 1987, J CLIN ENDOCR METAB, V65, P512, DOI 10.1210/jcem-65-3-512
   Goto A, 2013, BMJ-BRIT MED J, V347, DOI 10.1136/bmj.f4533
   Greene DA, 1999, EUR J PHARMACOL, V375, P217, DOI 10.1016/S0014-2999(99)00356-8
   GROOP LC, 1989, J CLIN INVEST, V84, P205, DOI 10.1172/JCI114142
   Gyurko R, 2006, J IMMUNOL, V177, P7250, DOI 10.4049/jimmunol.177.10.7250
   HAMSTEN A, 1985, NEW ENGL J MED, V313, P1557, DOI 10.1056/NEJM198512193132501
   Han S, 2006, CELL METAB, V3, P257, DOI 10.1016/j.cmet.2006.02.008
   Hancock CR, 2008, P NATL ACAD SCI USA, V105, P7815, DOI 10.1073/pnas.0802057105
   Heineke J, 2006, NAT REV MOL CELL BIO, V7, P589, DOI 10.1038/nrm1983
   Hink U, 2001, CIRC RES, V88, pE14
   Huo L, 2001, MOL CELL BIOL, V21, P644, DOI 10.1128/MCB.21.2.644-654.2001
   Huss JM, 2004, CIRC RES, V95, P568, DOI 10.1161/01.RES.0000141774.29937.e3
   KANNEL WB, 1974, AM J CARDIOL, V34, P29, DOI 10.1016/0002-9149(74)90089-7
   Kelly DP, 2004, GENE DEV, V18, P357, DOI 10.1101/gad.1177604
   Kern PA, 1997, J NUTR, V127, pS1917, DOI 10.1093/jn/127.9.1917S
   Khamaisi M, 1997, METABOLISM, V46, P763, DOI 10.1016/S0026-0495(97)90120-7
   Kim JA, 2008, CIRC RES, V102, P401, DOI 10.1161/CIRCRESAHA.107.165472
   Kim YJ, 2008, NUTR RES, V28, P414, DOI 10.1016/j.nutres.2008.03.015
   Koh KK, 2005, J AM COLL CARDIOL, V45, P1649, DOI 10.1016/j.jacc.2005.02.052
   Kuboki K, 2000, CIRCULATION, V101, P676, DOI 10.1161/01.CIR.101.6.676
   Laine M, 1998, J CLIN INVEST, V101, P1156, DOI 10.1172/JCI1065
   Langin D, 2005, DIABETES, V54, P3190, DOI 10.2337/diabetes.54.11.3190
   Lehman JJ, 2000, J CLIN INVEST, V106, P847, DOI 10.1172/JCI10268
   Lowell BB, 2005, SCIENCE, V307, P384, DOI 10.1126/science.1104343
   Lum H, 2001, AM J PHYSIOL-CELL PH, V280, pC719
   Lumeng CN, 2007, J CLIN INVEST, V117, P175, DOI 10.1172/JCI29881
   Mather KJ, 2004, DIABETES, V53, P2060, DOI 10.2337/diabetes.53.8.2060
   McFarlane SI, 2001, J CLIN ENDOCR METAB, V86, P713, DOI 10.1210/jc.86.2.713
   Mehta PK, 2007, AM J PHYSIOL-CELL PH, V292, pC82, DOI 10.1152/ajpcell.00287.2006
   Mitchell TH, 1997, AM J MED, V102, P531, DOI 10.1016/S0002-9343(97)00051-X
   Mootha VK, 2003, NAT GENET, V34, P267, DOI 10.1038/ng1180
   Morino K, 2006, DIABETES, V55, pS9, DOI 10.2337/db06-S002
   Nishikawa T, 2000, NATURE, V404, P787, DOI 10.1038/35008121
   Ogihara T, 2004, DIABETOLOGIA, V47, P794, DOI 10.1007/s00125-004-1391-x
   Patti ME, 2003, P NATL ACAD SCI USA, V100, P8466, DOI 10.1073/pnas.1032913100
   Paz K, 1997, J BIOL CHEM, V272, P29911, DOI 10.1074/jbc.272.47.29911
   Permana PA, 2006, BIOCHEM BIOPH RES CO, V341, P507, DOI 10.1016/j.bbrc.2006.01.012
   Pessler D, 2001, DIABETOLOGIA, V44, P2156, DOI 10.1007/s001250100024
   Petersen KF, 2004, NEW ENGL J MED, V350, P664, DOI 10.1056/NEJMoa031314
   Poirier P, 2006, CIRCULATION, V113, P898, DOI 10.1161/CIRCULATIONAHA.106.171016
   Potashnik R, 2003, DIABETOLOGIA, V46, P639, DOI 10.1007/s00125-003-1097-5
   Proud CG, 2007, BIOCHEM J, V403, P217, DOI 10.1042/BJ20070024
   Pyorala K, 1979, Diabetes Care, V2, P131, DOI 10.2337/diacare.2.2.131
   Ramkhelawon B, 2014, NAT MED, V20, P377, DOI 10.1038/nm.3467
   RANDLE PJ, 1988, DIABETES METAB REV, V4, P623, DOI 10.1002/dmr.5610040702
   RANDLE PJ, 1963, LANCET, V1, P785
   REAVEN GM, 1991, AM J HYPERTENS, V4, P34, DOI 10.1093/ajh/4.1.34
   Reaven GM, 1996, NEW ENGL J MED, V334, P374, DOI 10.1056/NEJM199602083340607
   Renard CB, 2004, J CLIN INVEST, V114, P659, DOI 10.1172/JCI200417867
   Ridker PM, 1997, NEW ENGL J MED, V336, P973, DOI 10.1056/NEJM199704033361401
   Ritz P, 2005, DIABETES METAB, V31, pS67, DOI 10.1016/S1262-3636(05)73654-5
   Ruan H, 2002, DIABETES, V51, P1319, DOI 10.2337/diabetes.51.5.1319
   Russell LK, 2004, CIRC RES, V94, P525, DOI 10.1161/01.RES.0000117088.36577.EB
   SADUR CN, 1984, J CLIN ENDOCR METAB, V59, P1176, DOI 10.1210/jcem-59-6-1176
   Savage DB, 2005, HYPERTENSION, V45, P828, DOI 10.1161/01.HYP.0000163475.04421.e4
   Schächinger V, 2000, CIRCULATION, V101, P1899, DOI 10.1161/01.CIR.101.16.1899
   Schram MT, 2003, DIABETES CARE, V26, P2165, DOI 10.2337/diacare.26.7.2165
   SECHI LA, 1992, METABOLISM, V41, P1261, DOI 10.1016/0026-0495(92)90019-7
   Seidell JC, 2001, AM J CLIN NUTR, V74, P315
   Sell H, 2012, NAT REV ENDOCRINOL, V8, P709, DOI 10.1038/nrendo.2012.114
   SHEN DC, 1988, J CLIN ENDOCR METAB, V66, P580, DOI 10.1210/jcem-66-3-580
   Shulman GI, 2000, J CLIN INVEST, V106, P171, DOI 10.1172/JCI10583
   Sommerfield AJ, 2007, AM J PHYSIOL-ENDOC M, V293, pE1274, DOI 10.1152/ajpendo.00114.2007
   SOWERS JR, 1994, J LAB CLIN MED, V123, P647
   Spallone V, 2011, DIABETES-METAB RES, V27, P639, DOI 10.1002/dmrr.1239
   STALDER M, 1981, DIABETOLOGIA, V21, P544
   Steinberg HO, 1996, J CLIN INVEST, V97, P2601, DOI 10.1172/JCI118709
   Steinberger J, 2003, CIRCULATION, V107, P1448, DOI 10.1161/01.CIR.0000060923.07573.F2
   Stojiljkovic MP, 2002, J HYPERTENS, V20, P1215, DOI 10.1097/00004872-200206000-00036
   Suzuki M, 1996, HYPERTENSION, V28, P593, DOI 10.1161/01.HYP.28.4.593
   Ting HH, 1996, J CLIN INVEST, V97, P22, DOI 10.1172/JCI118394
   Turer AT, 2012, CIRC RES, V111, P1565, DOI [10.1161/CIRCRESAHA.111.262493, 10.1161/circresaha.111.262493]
   TURNER RC, 1993, J HYPERTENS, V11, P309
   Van Gaal LF, 2006, NATURE, V444, P875, DOI 10.1038/nature05487
   Versari D, 2009, DIABETES CARE, V32, pS314, DOI 10.2337/dc09-S330
   Watts GF, 1998, ATHEROSCLEROSIS, V141, P17, DOI 10.1016/S0021-9150(98)00170-1
   Westerbacka J, 1999, DIABETES, V48, P821, DOI 10.2337/diabetes.48.4.821
   Whaley-Connell A, 2007, AM J PHYSIOL-ENDOC M, V293, pE355, DOI 10.1152/ajpendo.00632.2006
   Wiman B, 2000, ARTERIOSCL THROM VAS, V20, P2019, DOI 10.1161/01.ATV.20.8.2019
   Witte DR, 2005, DIABETOLOGIA, V48, P164, DOI 10.1007/s00125-004-1617-y
   WOLFF SP, 1987, BIOCHEM J, V245, P243, DOI 10.1042/bj2450243
   Yamagishi SI, 2001, J BIOL CHEM, V276, P25096, DOI 10.1074/jbc.M007383200
   Yan SD, 1997, EUR J CLIN INVEST, V27, P179, DOI 10.1046/j.1365-2362.1996.00072.x
   Yang RH, 2007, CIRC RES, V101, P545, DOI 10.1161/CIRCRESAHA.107.156596
   Zick Yehiel, 2005, Sci STKE, V2005, ppe4, DOI 10.1126/stke.2682005pe4
NR 117
TC 178
Z9 198
U1 0
U2 40
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1382-4147
EI 1573-7322
J9 HEART FAIL REV
JI Heart Fail. Rev.
PD JAN
PY 2016
VL 21
IS 1
BP 11
EP 23
DI 10.1007/s10741-015-9515-6
PG 13
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DB0FH
UT WOS:000368183500002
PM 26542377
DA 2025-06-11
ER

PT J
AU Zhang, YM
   Zhang, ZY
   Wang, RX
AF Zhang, Yu-Min
   Zhang, Zhen-Ye
   Wang, Ru-Xing
TI Protective Mechanisms of Quercetin Against Myocardial Ischemia
   Reperfusion Injury
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE quercetin; ischemia; reperfusion injury; oxidative stress;
   vasodilatation; calcium overload
ID OXIDATIVE STRESS; NITRIC-OXIDE; NADPH OXIDASES; ETB RECEPTORS;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; CORONARY-ARTERIES;
   UP-REGULATION; IN-VITRO; APOPTOSIS
AB Quercetin has attracted more attention in recent years due to its protective role against ischemia/reperfusion injury. Quercetin can alleviate oxidative stress injury through the inhibition of NADPH oxidase and xanthine oxidase, blockage of the Fenton reaction, and scavenging of reactive oxygen species. Quercetin can also exert anti-inflammatory and anti-apoptotic effects by reducing the response to inflammatory factors and inhibiting cell apoptosis. Moreover, it can induce vasodilation effects through the inhibition of endothelin-1 receptors, the enhancement of NO stimulation and the activation of the large-conductance calcium-activated potassium channels. Finally, Quercetin can also antagonize the calcium overload. These multifaceted activities of Quercetin make it a potential therapeutic alternative for the treatment of ischemia/reperfusion injury.
C1 [Zhang, Yu-Min; Zhang, Zhen-Ye; Wang, Ru-Xing] Nanjing Med Univ, Wuxi Peoples Hosp, Dept Cardiol, Wuxi, Jiangsu, Peoples R China.
C3 Nanjing Medical University; Jiangnan University
RP Wang, RX (corresponding author), Nanjing Med Univ, Wuxi Peoples Hosp, Dept Cardiol, Wuxi, Jiangsu, Peoples R China.
EM ruxingw@aliyun.com
RI Zhang, Zhenye/AAC-6226-2022
FU National Natural Science Foundation of China [81770331]; Natural Science
   Foundation of Jiangsu Province [BK20151110]
FX This study was supported in part by grants from the National Natural
   Science Foundation of China (81770331) and the Natural Science
   Foundation of Jiangsu Province (BK20151110).
CR Akcaboy M, 2016, PEDIATR NEPHROL, V31, P473, DOI 10.1007/s00467-015-3223-2
   Akhlaghi M, 2009, J MOL CELL CARDIOL, V46, P309, DOI 10.1016/j.yjmcc.2008.12.003
   Amiot MJ, 2016, OBES REV, V17, P573, DOI 10.1111/obr.12409
   Andres S, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700447
   Anilkumar N, 2009, FRONT BIOSCI-LANDMRK, V14, P3168, DOI 10.2741/3443
   Arkat S, 2016, FREE RADICAL BIO MED, V97, P489, DOI 10.1016/j.freeradbiomed.2016.06.019
   Babenkova IV, 2018, B EXP BIOL MED+, V165, P347, DOI 10.1007/s10517-018-4167-x
   Bahem R, 2015, PLANTA MED, V81, P670, DOI 10.1055/s-0034-1383408
   Barteková M, 2015, INT J MOL SCI, V16, P8168, DOI 10.3390/ijms16048168
   Becker LB, 2004, CARDIOVASC RES, V61, P461, DOI 10.1016/j.cardiores.2003.10.025
   Benito S, 2002, BRIT J PHARMACOL, V135, P910, DOI 10.1038/sj.bjp.0704534
   Brandes RP, 2014, FREE RADICAL BIO MED, V76, P208, DOI 10.1016/j.freeradbiomed.2014.07.046
   Breitenbach M, 2018, WIEN MED WOCHENSCHR, V168, P286, DOI 10.1007/s10354-018-0640-4
   Brosková Z, 2013, PHYTOTHER RES, V27, P1018, DOI 10.1002/ptr.4825
   Burak C, 2019, NUTRITION, V58, P47, DOI 10.1016/j.nut.2018.06.012
   Cao H, 2017, BIOMED PHARMACOTHER, V95, P938, DOI 10.1016/j.biopha.2017.08.128
   Chen X, 2018, FOOD RES INT, V114, P30, DOI 10.1016/j.foodres.2018.07.062
   Chen YW, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/364519
   Chouchani ET, 2014, NATURE, V515, P431, DOI 10.1038/nature13909
   Cogolludo A, 2007, CARDIOVASC RES, V73, P424, DOI 10.1016/j.cardiores.2006.09.008
   Dabeek WM, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102288
   Dammanahalli KJ, 2008, CLIN EXP PHARMACOL P, V35, P2, DOI 10.1111/j.1440-1681.2007.04830.x
   Dhiman P, 2018, CURR TOP MED CHEM, V18, P1857, DOI 10.2174/1568026618666181115095204
   Dian LH, 2014, NANOSCALE RES LETT, V9, DOI 10.1186/1556-276X-9-684
   Drummond GR, 2014, TRENDS ENDOCRIN MET, V25, P452, DOI 10.1016/j.tem.2014.06.012
   Duarte J, 2004, PHYSIOL RES, V53, P595, DOI 10.33549/physiolres.930000.53.595
   Eitah HE, 2019, TOXICOL APPL PHARM, V365, P30, DOI 10.1016/j.taap.2018.12.011
   Ekoue DN, 2017, BBA-BIOENERGETICS, V1858, P628, DOI 10.1016/j.bbabio.2017.01.006
   Grande F, 2016, EUR J PHARM SCI, V82, P161, DOI 10.1016/j.ejps.2015.11.021
   Guichard C, 2006, M S-MED SCI, V22, P953, DOI 10.1051/medsci/20062211953
   Guo XP, 2018, MOL NUTR FOOD RES, V62, DOI [10.1002/mnfr.201700772, 10.1002/mnfr.201870045]
   He SF, 2017, BIOMED PHARMACOTHER, V91, P1106, DOI 10.1016/j.biopha.2017.05.003
   Hinchy EC, 2018, J BIOL CHEM, V293, P17208, DOI 10.1074/jbc.RA118.002579
   Hou XM, 2014, PLANTA MED, V80, P465, DOI 10.1055/s-0034-1368320
   Huang CH, 2015, EUR J CARDIO-THORAC, V48, P382, DOI 10.1093/ejcts/ezu453
   Huang JQ, 2011, FOOD CHEM TOXICOL, V49, P1943, DOI 10.1016/j.fct.2011.04.029
   Iglarz M, 2015, J CARDIOVASC PHARM, V66, P332, DOI 10.1097/FJC.0000000000000283
   Iskender H, 2017, BIOMED PHARMACOTHER, V90, P500, DOI 10.1016/j.biopha.2017.03.102
   Jia LJ, 2018, LIFE SCI, V208, P123, DOI 10.1016/j.lfs.2018.07.027
   Jiang W, 2018, ACS APPL MATER INTER, V10, P34513, DOI 10.1021/acsami.8b13487
   Jomova K, 2017, FOOD CHEM TOXICOL, V110, P340, DOI 10.1016/j.fct.2017.10.042
   Joshi T, 2019, J CELL PHYSIOL, V234, P17212, DOI 10.1002/jcp.28528
   Jung CH, 2013, PHYTOTHER RES, V27, P139, DOI 10.1002/ptr.4687
   Kaoukis A, 2013, CURR TOP MED CHEM, V13, P95, DOI 10.2174/1568026611313020003
   Lee FY, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19092782
   Lei CS, 2018, J NUTR BIOCHEM, V51, P105, DOI 10.1016/j.jnutbio.2017.09.011
   Leiherer A, 2016, NUTRIENTS, V8, DOI 10.3390/nu8050282
   Li J, 2012, J MOL CELL CARDIOL, V52, P865, DOI 10.1016/j.yjmcc.2011.08.027
   Li PG, 2012, PHARMACOLOGY, V89, P220, DOI 10.1159/000337182
   Li YB, 2019, J CELL BIOCHEM, V120, P13680, DOI 10.1002/jcb.28641
   Lichtenauer M, 2017, CLIN HEMORHEOL MICRO, V67, P101, DOI 10.3233/CH-170273
   Liu H, 2012, MOLECULES, V17, P4281, DOI 10.3390/molecules17044281
   Loke WM, 2008, AM J CLIN NUTR, V88, P1018, DOI 10.1093/ajcn/88.4.1018
   Lu XL, 2017, BIOMED PHARMACOTHER, V85, P658, DOI 10.1016/j.biopha.2016.11.077
   Martyn KD, 2006, CELL SIGNAL, V18, P69, DOI 10.1016/j.cellsig.2005.03.023
   Maurya AK, 2015, TUMOR BIOL, V36, P8913, DOI 10.1007/s13277-015-3634-5
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Nettore IC, 2019, J NUTR BIOCHEM, V69, P151, DOI 10.1016/j.jnutbio.2019.03.019
   Patel RV, 2018, EUR J MED CHEM, V155, P889, DOI 10.1016/j.ejmech.2018.06.053
   Perez-Vizcaino F, 2018, ARCH BIOCHEM BIOPHYS, V646, P107, DOI 10.1016/j.abb.2018.03.022
   Rauf A, 2018, PHYTOTHER RES, V32, P2109, DOI 10.1002/ptr.6155
   Rendig SV, 2001, J CARDIOVASC PHARM, V38, P219, DOI 10.1097/00005344-200108000-00007
   Rocca C, 2018, ACTA PHYSIOL, V223, DOI 10.1111/apha.13067
   Rocca C, 2019, CELL MOL LIFE SCI, V76, P3969, DOI 10.1007/s00018-019-03195-1
   Rohrbach S, 2015, IUBMB LIFE, V67, P110, DOI 10.1002/iub.1352
   Romero M, 2009, ATHEROSCLEROSIS, V202, P58, DOI 10.1016/j.atherosclerosis.2008.03.007
   Sakanashi Y, 2008, LIFE SCI, V83, P164, DOI 10.1016/j.lfs.2008.05.009
   Sánchez M, 2006, J HYPERTENS, V24, P75, DOI 10.1097/01.hjh.0000198029.22472.d9
   Sarkar A, 2012, J MOL MODEL, V18, P2621, DOI 10.1007/s00894-011-1274-2
   Seidlmayer LK, 2015, CARDIOVASC RES, V106, P237, DOI 10.1093/cvr/cvv097
   Siasos G, 2013, CURR MED CHEM, V20, P2641, DOI 10.2174/0929867311320210003
   Silberman GA, 2010, CIRCULATION, V121, P519, DOI 10.1161/CIRCULATIONAHA.109.883777
   Simmonds MJ, 2014, BIORHEOLOGY, V51, P121, DOI 10.3233/BIR-140653
   Skovsted GF, 2014, BRIT J PHARMACOL, V171, P2726, DOI 10.1111/bph.12606
   Son M, 2014, J NEUROL SCI, V336, P1, DOI 10.1016/j.jns.2013.11.004
   Stein WD, 2002, INT REV CYTOL, V215, P231
   Steinbrenner H, 2016, ARCH BIOCHEM BIOPHYS, V595, P113, DOI 10.1016/j.abb.2015.06.024
   Sugamura K, 2011, FREE RADICAL BIO MED, V51, P978, DOI 10.1016/j.freeradbiomed.2011.05.004
   Suganthy N, 2016, BIOMED PHARMACOTHER, V84, P892, DOI 10.1016/j.biopha.2016.10.011
   Suri S, 2010, BRIT J PHARMACOL, V159, P566, DOI 10.1111/j.1476-5381.2009.00556.x
   Tang L, 2013, MOL CELL BIOCHEM, V382, P145, DOI 10.1007/s11010-013-1729-0
   Tang ST, 2017, VASC PHARMACOL, V88, P48, DOI 10.1016/j.vph.2016.12.002
   Tawani A, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-03906-3
   Terao J, 2017, BIOCHEM PHARMACOL, V139, P15, DOI 10.1016/j.bcp.2017.03.021
   Thomas C, 2009, REDOX REP, V14, P102, DOI 10.1179/135100009X392566
   Tu CC, 2020, LIFE SCI, V247, DOI 10.1016/j.lfs.2019.116560
   Van den Eynde MDG, 2018, J NUTR, V148, P1911, DOI 10.1093/jn/nxy236
   Wackenfors A, 2004, EUR J PHARMACOL, V484, P103, DOI 10.1016/j.ejphar.2003.11.001
   Wan LL, 2009, CARDIOVASC THER, V27, P28, DOI 10.1111/j.1755-5922.2009.00071.x
   Wang LR, 2019, J PHOTOCH PHOTOBIO B, V196, DOI 10.1016/j.jphotobiol.2019.05.005
   Wilson AJ, 2018, HEART, V104, P293, DOI 10.1136/heartjnl-2017-311448
   Wu MY, 2018, CELL PHYSIOL BIOCHEM, V46, P1650, DOI 10.1159/000489241
   Xu D, 2019, MOLECULES, V24, DOI 10.3390/molecules24061123
   Yang YJ, 2018, J AM HEART ASSOC, V7, DOI 10.1161/JAHA.118.008807
   Yu LM, 2017, APOPTOSIS, V22, P942, DOI 10.1007/s10495-017-1378-y
   Zhang C, 2018, INT J BIOL MACROMOL, V112, P405, DOI 10.1016/j.ijbiomac.2018.01.190
   Zhang LM, 2018, J AGR FOOD CHEM, V66, P1723, DOI 10.1021/acs.jafc.8b00054
   Zhao DJ, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/6437467
   Zou CL, 2018, J PHARMACOL SCI, V138, P161, DOI 10.1016/j.jphs.2018.09.008
NR 99
TC 70
Z9 76
U1 0
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD JUL 31
PY 2020
VL 11
AR 956
DI 10.3389/fphys.2020.00956
PG 12
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA ND1KH
UT WOS:000561664400001
PM 32848878
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ma, SL
   Ju, PJ
   Xia, QR
   Pan, ZD
   Gao, JL
   Zhang, LF
   Gao, H
   Yan, JW
   Zhang, J
   Wang, KM
   Li, C
   Xie, W
   Zhu, CZ
AF Ma, Shenglan
   Ju, Peijun
   Xia, Qingrong
   Pan, Zhongde
   Gao, Jianliang
   Zhang, Loufeng
   Gao, Hua
   Yan, Junwei
   Zhang, Jie
   Wang, Keming
   Li, Chao
   Xie, Wen
   Zhu, Cuizhen
TI Automatic Thoughts, Self-Stigma, and Resilience Among Schizophrenia
   Patients with Metabolic Syndrome: A Cross-Sectional Study
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Article
DE years of education; negative symptoms; waist circumstance
ID QUALITY-OF-LIFE; INTERNALIZED STIGMA; DRUG-NAIVE; PEOPLE; PSYCHOSIS;
   ILLNESS; SCALE
AB Purpose: The study aims to clarify the negative psychological state and resilience impairments of schizophrenia (SCZ) with metabolic syndrome (MetS) while evaluating their potential as risk factors.Patients and Methods: We recruited 143 individuals and divided them into three groups. Participants were evaluated using the Positive and Negative Syndrome Scale (PANSS), Hamilton Depression Rating Scale (HAMD)-24, Hamilton Anxiety Rating Scale (HAMA)-14, Automatic Thoughts Questionnaire (ATQ), Stigma of Mental Illness scale and Connor-Davidson Resilience Scale (CDRISC). Serum biochemical parameters were measured by automatic biochemistry analyzer.Results: The score of ATQ was highest in the MetS group (F = 14.5, p < 0.001), and the total score of CD-RISC, subscale tenacity score and subscale strength score of CD-RISC were lowest in the MetS group (F = 8.54, p < 0.001; F = 5.79, p = 0.004; F = 10.9, p < 0.001). A stepwise regression analysis demonstrated that a negative correlation was observed among the ATQ with employment status, high-density lipoprotein (HDL-C), and CD-RISC (13=-0.190, t=-2.297, p = 0.023; 13=-0.278, t=-3.437, p = 0.001; 13=-0.238, t= -2.904, p = 0.004). A positive correlation was observed among the ATQ with waist, TG, WBC, and stigma (13=0.271, t = 3.340, p = 0.001; 13=0.283, t = 3.509, p = 0.001; 13=0.231, t = 2.815, p = 0.006; 13=0.251, t=-2.504, p = 0.014). The area under the receiveroperating characteristic curve analysis showed that among all independent predictors of ATQ, the TG, waist, HDL-C, CD-RISC, and stigma presented excellent specificity at 0.918, 0.852, 0.759, 0.633, and 0.605, respectively.Conclusion: Results suggested that the non-MetS and MetS groups had grievous sense of stigma, particularly, high degree of ATQ and resilience impairment was shown by the MetS group. The TG, waist, HDL-C of metabolic parameters, CD-RISC, and stigma presented excellent specificity to predict ATQ, and the waist showed excellent specificity to predict low resilience level.
C1 [Ma, Shenglan; Xia, Qingrong; Gao, Jianliang; Zhang, Loufeng; Gao, Hua; Yan, Junwei; Zhang, Jie; Wang, Keming; Li, Chao; Xie, Wen; Zhu, Cuizhen] Anhui Med Univ, Affiliated Psychol Hosp, 316 Huangshan Rd, Hefei 230022, Anhui, Peoples R China.
   [Ma, Shenglan; Xia, Qingrong; Gao, Jianliang; Zhang, Loufeng; Gao, Hua; Yan, Junwei; Zhang, Jie; Wang, Keming; Li, Chao; Xie, Wen; Zhu, Cuizhen] Hefei Fourth Peoples Hosp, Clin Ctr Psychiat & Mental Hlth, Hefei 230022, Peoples R China.
   [Ma, Shenglan; Xia, Qingrong; Gao, Jianliang; Zhang, Loufeng; Gao, Hua; Yan, Junwei; Zhang, Jie; Wang, Keming; Li, Chao; Xie, Wen; Zhu, Cuizhen] Anhui Mental Hlth Ctr, Hefei, Peoples R China.
   [Ju, Peijun] Shanghai Jiao Tong Univ, Shanghai Inst Tradit Chinese Med Mental Hlth, Sch Med, Shanghai Mental Hlth Ctr, Shanghai, Peoples R China.
   [Pan, Zhongde] Acad Forens Sci, Shanghai Key Lab Forens Med, Shanghai, Peoples R China.
C3 Anhui Medical University; Shanghai Jiao Tong University
RP Xie, W; Zhu, CZ (corresponding author), Anhui Med Univ, Affiliated Psychol Hosp, 316 Huangshan Rd, Hefei 230022, Anhui, Peoples R China.
EM xiewen0808@sina.com; zhucuizhen88@126.com
RI Wang, Keming/AAY-8013-2021
FU central public welfare research institutes [GY2020G-3]; Applied medicine
   research project of Hefei Health Committee [Hwk2020zd0016]; Applied
   medicine research project of Anhui Health Committee [AHWJ2021a036]; Key
   research and development plan projects in Anhui Province [2022e07020002]
FX Acknowledgments This study was supported by funding of central public
   welfare research institutes (grant number: GY2020G-3) , Applied medicine
   research project of Hefei Health Committee (grant number: Hwk2020zd0016)
   and Applied medicine research project of Anhui Health Committee (grant
   number: AHWJ2021a036) and Key research and development plan projects in
   Anhui Province (grant number: 2022e07020002) . The funding sources had
   no involvement in study design, collection, analysis, writing of this
   paper and publication.
CR Altun ÖS, 2022, PERSPECT PSYCHIATR C, V58, P1819, DOI 10.1111/ppc.12994
   Anonymous, 2007, Zhonghua Xinxueguanbing Zazhi, V35, P390
   Boyd JE, 2014, COMPR PSYCHIAT, V55, P221, DOI 10.1016/j.comppsych.2013.06.005
   Bozikas VP, 2016, J NERV MENT DIS, V204, P578, DOI 10.1097/NMD.0000000000000541
   Brohan E, 2010, BMC HEALTH SERV RES, V10, DOI 10.1186/1472-6963-10-80
   Carney R, 2016, SCHIZOPHR RES, V170, P290, DOI 10.1016/j.schres.2016.01.010
   Connor KM, 2003, DEPRESS ANXIETY, V18, P76, DOI 10.1002/da.10113
   Corrigan PW, 2014, PSYCHIAT RES, V218, P35, DOI 10.1016/j.psychres.2014.04.028
   Dai J, 2018, SCHIZOPHR RES, V193, P182, DOI 10.1016/j.schres.2017.06.029
   Emul M, 2015, NEUROPSYCH DIS TREAT, V11, P2493, DOI 10.2147/NDT.S50006
   First MB, 2013, J NERV MENT DIS, V201, P727, DOI 10.1097/NMD.0b013e3182a2168a
   Gross J, 2016, DISABIL REHABIL, V38, P123, DOI 10.3109/09638288.2015.1024343
   Haig GM, 2018, J CLIN PSYCHIAT, V79, DOI 10.4088/JCP.16m11162
   Hasnain M, 2010, CURR DIABETES REP, V10, P209, DOI 10.1007/s11892-010-0112-8
   Hofer A, 2016, SCHIZOPHR RES, V171, P86, DOI 10.1016/j.schres.2016.01.027
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Ijaz Sharea, 2020, Focus (Am Psychiatr Publ), V18, P482, DOI 10.1176/appi.focus.18307
   Ivezic SS, 2017, PSYCHIAT DANUB, V29, P66
   Komatsu H, 2021, BMC PSYCHIATRY, V21, DOI 10.1186/s12888-021-03472-z
   Küçükkubas N, 2019, SCI SPORT, V34, pE259, DOI 10.1016/j.scispo.2018.11.006
   Kucukkubas N, 2019, International Journal of Sport, Exercise & Training Sciences, V5, P68, DOI [10.18826/useeabd.517037, DOI 10.18826/USEEABD.517037]
   Laursen TM, 2012, CURR OPIN PSYCHIATR, V25, P83, DOI 10.1097/YCO.0b013e32835035ca
   Li JF, 2020, J NURS RES, V28, DOI 10.1097/jnr.0000000000000380
   Lin P, 2022, GEN PSYCHIAT, V35, DOI 10.1136/gpsych-2021-100685
   Liu JC, 2022, MEDICINE, V101, DOI 10.1097/MD.0000000000029775
   Malan-Müller S, 2016, SCHIZOPHR RES, V170, P1, DOI 10.1016/j.schres.2015.11.011
   Malhotra Nidhi, 2013, Indian J Psychol Med, V35, P227, DOI 10.4103/0253-7176.119471
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Mizuno Y, 2018, ACTA PSYCHIAT SCAND, V137, P316, DOI 10.1111/acps.12838
   Mosanya TJ, 2014, INT J SOC PSYCHIATR, V60, P377, DOI 10.1177/0020764013491738
   North HF, 2021, TRANSL PSYCHIAT, V11, DOI 10.1038/s41398-021-01742-8
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Popa CO, 2022, J CLIN MED, V11, DOI 10.3390/jcm11030871
   Ringen PA, 2014, FRONT PSYCHIATRY, V5, DOI 10.3389/fpsyt.2014.00137
   Sahpolat M, 2021, CLIN PSYCHOPHARM NEU, V19, P112, DOI 10.9758/cpn.2021.19.1.112
   Sahpolat M, 2021, NORD J PSYCHIAT, V75, P73, DOI 10.1080/08039488.2020.1815080
   Sahpolat M, 2020, CLIN PSYCHOPHARM NEU, V18, P109, DOI 10.9758/cpn.2020.18.1.109
   SENORMANCI G, 2022, TURK PSIKIYATR DERG, V33, P1, DOI 10.5080/u25738
   Sevi OM, 2013, Anatol J Clin Investig, V7, P1
   [司天梅 SI Tian-Mei], 2009, [中国心理卫生杂志, Chinese Mental Health Journal], V23, P493
   Spor U., 2019, International Journal of Sport, Exercise Training Sciences, V5, P15, DOI [https://doi.org/10.18826/USEEABD.510426, DOI 10.18826/USEEABD.510426]
   Sugawara N, 2016, NEUROPSYCH DIS TREAT, V12, P427, DOI 10.2147/NDT.S98711
   Sun LY, 2022, GEN PSYCHIAT, V35, DOI 10.1136/gpsych-2022-100889
   Sun MJ, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17186700
   Takeda T, 2019, NEUROPSYCH DIS TREAT, V15, P293, DOI 10.2147/NDT.S190381
   Thakore JH, 2002, INT J OBESITY, V26, P137, DOI 10.1038/sj.ijo.0801840
   Valery KM, 2020, PSYCHIAT RES, V290, DOI 10.1016/j.psychres.2020.113068
   Wong DFK, 2007, INT J GROUP PSYCHOTH, V57, P367, DOI 10.1521/ijgp.2007.57.3.367
   Wu BJ, 2015, SCHIZOPHR RES, V169, P489, DOI 10.1016/j.schres.2015.09.011
   Yaprak Y, 2020, PROG NUTR, V22, DOI 10.23751/pn.v22i3.9334
   Zhang XY, 2022, NEUROPSYCH DIS TREAT, V18, P1087, DOI 10.2147/NDT.S367392
NR 51
TC 3
Z9 3
U1 4
U2 12
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2023
VL 19
BP 1195
EP 1206
DI 10.2147/NDT.S407662
PG 12
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA H2KX0
UT WOS:000994316200001
PM 37220563
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bitzer, J
   Platano, G
   Tschudin, S
   Alder, J
AF Bitzer, Johannes
   Platano, Giacomo
   Tschudin, S.
   Alder, Judith
TI Sexual counseling for women in the context of physical diseases - A
   teaching model for physicians
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE sexual dysfunction; physical diseases; pathogenetic model; diagnostic
   workup; training module
ID BREAST-CANCER SURVIVORS; QUALITY-OF-LIFE; RADICAL HYSTERECTOMY;
   BODY-IMAGE; DYSFUNCTION; POPULATION; ADJUSTMENT; DESIRE; ASSOCIATION;
   PREVALENCE
AB Introduction. Chronic medical conditions are frequently associated with sexual difficulties and problems, which are often underreported and underdiagnosed. Patients may feel that sexual problems in the context of disease are not important enough to be mentioned to their physicians, and physicians may feel uncomfortable and sometimes incompetent. Furthermore, the diagnostic criteria of Diagnostic and Statistical Manual of Mental Disorders-IV and International Classification of Diseases-10 are focused on the phenomenology of the sexual response without any specificity regarding diseases.
   Aim. To facilitate access for patients and physicians, we wanted to develop a tool for assessment and discussion of sexual problems in the context of disease. This tool should be broadly applicable, easy to use and learn for nonmental health professionals.
   Main Outcome Measures. Content analysis with respect to the integration of general sexological and disease-specific dimensions. Formulation of a diagnostic and therapeutic algorithm that can be used as a teaching tool.
   Methods. Based on our experience as a liaison-consultation sexological division of the university hospital of Basel, we analyzed the sexological diagnostic workup performed with the following group of female patients: women with benign gynecologic conditions; women with incontinence; oncological patients (mammary carcinoma, genital carcinoma); neurological patients (multiple sclerosis, spine injury, Parkinson's); patients with metabolic and endocrine disorders (diabetes, metabolic syndrome, polycystic ovarian syndrome); and patients with mental health disorders (depression, anxiety disorder, schizophrenia). We extracted the commonly used steps in the workup to construct a tool with easy-to-remember elements, which would help the physician to evaluate patients' sexual problems and plan for referral or therapy.
   Results. We could differentiate three diagnostic dimensions. The first were person-related preexisting factors, such as sexual satisfaction and function, age, body image, and general well-being. The second were the disease-specific implications, which could be summarized under the 8 Ds: Danger, Destruction, Disfigurement, Disability and pain, Dysfunction, Dysregulation, Disease load, and Drugs. The third was the patient's and partner's general response to the disease determined by affective response, coping style, body image impact, and changes in relationship dynamics.
   Conclusion. Sexual problems are frequent in many clinical conditions, but are not yet a routine part of diagnostic workup and therapeutic planning. We have developed a tool to help physicians in different clinical settings to evaluate sexual problems of the female patients with specific clinical conditions in order to facilitate access to recognition and possible treatment.
C1 Univ Basel Hosp, Dept Obstet & Gynecol, CH-4031 Basel, Switzerland.
   Univ Basel Hosp, Dept Gynecol Social Med & Psychosomat, CH-4031 Basel, Switzerland.
   Univ Basel Hosp, Dept Clin Psychol & Psychotherapy, CH-4031 Basel, Switzerland.
C3 University of Basel; University of Basel; University of Basel
RP Bitzer, J (corresponding author), Univ Basel Hosp, Dept Obstet & Gynecol, Spitalstr 21, CH-4031 Basel, Switzerland.
EM jbitzer@uhbs.ch
CR Althof SE, 2005, J SEX MED, V2, P793, DOI 10.1111/j.1743-6109.2005.00145.x
   *AM PSYCH ASS, 1996, DIAGN STAT MAN DIS
   Amsterdam A, 2006, J SEX MED, V3, P292, DOI 10.1111/j.1743-6109.2005.00172.x
   ANDERSEN B, 1989, J CONSULT CLIN PSYCH, V75, P683
   ANDERSEN BL, 1985, CANCER-AM CANCER SOC, V55, P1835, DOI 10.1002/1097-0142(19850415)55:8<1835::AID-CNCR2820550832>3.0.CO;2-K
   Bassetto A, 2004, J HIGH ENERGY PHYS
   Basson R, 2003, J PSYCHOSOM OBST GYN, V24, P221, DOI 10.3109/01674820309074686
   Basson R, 2006, NEW ENGL J MED, V354, P1497, DOI 10.1056/NEJMcp050154
   Basson R, 2005, J SEX MED, V2, P291, DOI 10.1111/j.1743-6109.2005.20346.x
   Basson R, 2004, J SEX MED, V1, P24, DOI 10.1111/j.1743-6109.2004.10105.x
   Bloom JR, 2004, PSYCHO-ONCOL, V13, P147, DOI 10.1002/pon.794
   Butler-Manuel SA, 2000, CANCER-AM CANCER SOC, V89, P834, DOI 10.1002/1097-0142(20000815)89:4<834::AID-CNCR16>3.0.CO;2-7
   Cundiff GW, 2004, OBSTET GYNECOL, V104, P1403, DOI 10.1097/01.AOG.0000147598.50638.15
   Davis SR, 2004, J SEX MED, V1, P82, DOI 10.1111/j.1743-6109.2004.10112.x
   Dennerstein L, 2004, J SEX MARITAL THER, V30, P173, DOI 10.1080/00926230490262375
   Devine D, 2003, PSYCHO-ONCOLOGY, V12, P453, DOI 10.1002/pon.656
   Dunn KM, 1999, J EPIDEMIOL COMMUN H, V53, P144, DOI 10.1136/jech.53.3.144
   Fokdal L, 2004, RADIOTHER ONCOL, V72, P139, DOI 10.1016/j.radonc.2004.05.006
   Ganz PA, 1996, BREAST CANCER RES TR, V38, P183, DOI 10.1007/BF01806673
   Graziottin A, 2004, MENOPAUSE, V11, P766, DOI 10.1097/01.GME.0000139926.02689.A1
   Graziottin A., 2000, MANAGE MENOP ANN REV, P211
   Gutweniger S, 1999, CLIN EXP RHEUMATOL, V17, P413
   Hatzichristou D, 2004, J SEX MED, V1, P49, DOI 10.1111/j.1743-6109.2004.10108.x
   HAWTON K, 1994, ARCH SEX BEHAV, V23, P375, DOI 10.1007/BF01541404
   HAYES Richard., 2006, Womens Sexual Function and Dysfuncion: Study, Diagnosis and Treatment, P245
   Heinemann LAJ, 2005, J SEX MED, V2, P82, DOI 10.1111/j.1743-6109.2005.20108.x
   Hennessey A, 1999, J NEUROL, V246, P1027, DOI 10.1007/s004150050508
   Jensen PT, 2004, CANCER, V100, P97, DOI 10.1002/cncr.11877
   Juraskova I, 2003, PSYCHO-ONCOLOGY, V12, P267, DOI 10.1002/pon.639
   KANG D, 2006, WOMENS SEXUAL FUNCTI, P721
   Kornblith AB, 2003, SEMIN ONCOL, V30, P799, DOI 10.1053/j.seminoncol.2003.08.025
   Krebs M, 2006, EXPERT OPIN PHARMACO, V7, P1005, DOI 10.1517/14656566.7.8.1005
   Lewis RW, 2004, J SEX MED, V1, P35, DOI 10.1111/j.1743-6109.2004.10106.x
   McKee AL, 2001, CANCER-AM CANCER SOC, V92, P1008, DOI 10.1002/1097-0142(20010815)92:4+<1008::AID-CNCR1413>3.0.CO;2-2
   Moreira ED, 2006, J SEX MED, V3, P201, DOI 10.1111/j.1743-6109.2006.00210.x
   Nappi R, 2005, J SEX MED, V2, P4, DOI 10.1111/j.1743-6109.2005.20102.x
   Northouse L L, 1994, J Natl Cancer Inst Monogr, P183
   Okeahialam BN, 2006, J NATL MED ASSOC, V98, P638
   Panush RS, 2000, B RHEUM DIS, V49, P1
   Parish SJ, 2002, 20 COMMON PROBLEMS B, P143
   Quirk F, 2005, J SEX MED, V2, P469, DOI 10.1111/j.1743-6109.2005.00076.x
   SALONIA A, 2002, INT J IMPOT RES S4, V14, P80
   SCHOVER LR, 1995, CANCER-AM CANCER SOC, V75, P54, DOI 10.1002/1097-0142(19950101)75:1<54::AID-CNCR2820750111>3.0.CO;2-I
   Schultz WW, 2005, J SEX MED, V2, P301, DOI 10.1111/j.1743-6109.2005.20347.x
   Segraves R, 2006, J SEX MED, V3, P408, DOI 10.1111/j.1743-6109.2006.00246.x
   Sheppard Caren, 2006, J Br Menopause Soc, V12, P24, DOI 10.1258/136218006775997216
   SIPSKI ML, 1993, ARCH PHYS MED REHAB, V74, P1025, DOI 10.1016/0003-9993(93)90056-G
   Stead ML, 2001, BRIT MED J, V323, P836, DOI 10.1136/bmj.323.7317.836
   Walker B L, 1997, Cancer Pract, V5, P92
   Wiegel M., 2006, WOMENS SEXUAL FUNCTI, P85
   Yu M, 2004, AM J GERIAT PSYCHIAT, V12, P221, DOI 10.1176/appi.ajgp.12.2.221
NR 51
TC 55
Z9 63
U1 0
U2 20
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 1743-6095
J9 J SEX MED
JI J. Sex. Med.
PD JAN
PY 2007
VL 4
IS 1
BP 29
EP 37
DI 10.1111/j.1743-6109.2006.00395.x
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Urology & Nephrology
GA 119PI
UT WOS:000243023900004
PM 17233774
DA 2025-06-11
ER

PT J
AU Shaaban, HH
   Alzaim, I
   El-Mallah, A
   Aly, RG
   El-Yazbi, AF
   Wahid, A
AF Shaaban, Hager H.
   Alzaim, Ibrahim
   El-Mallah, Ahmed
   Aly, Rania G.
   El-Yazbi, Ahmed F.
   Wahid, Ahmed
TI Metformin, pioglitazone, dapagliflozin and their combinations ameliorate
   manifestations associated with NAFLD in rats via anti-inflammatory,
   anti-fibrotic, anti-oxidant and anti-apoptotic mechanisms
SO LIFE SCIENCES
LA English
DT Article
DE NAFLD; Metabolic syndrome; Metformin; Pioglitazone; Dapagliflozin
ID NONALCOHOLIC FATTY LIVER; SELECTIVE INHIBITOR IPRAGLIFLOZIN; HEPATIC
   INSULIN-RESISTANCE; TYPE-2 DIABETES-MELLITUS; ACTIVATED PROTEIN-KINASE;
   TUMOR-NECROSIS-FACTOR; OXIDATIVE STRESS; GENE-EXPRESSION; VITAMIN-E;
   ENDOPLASMIC-RETICULUM
AB Non-alcoholic fatty liver disease (NAFLD) is an important health threat that is strongly linked to components of metabolic syndrome, particularly the low-grade inflammatory changes. Significantly, several of the available anti-diabetic drug classes demonstrate a considerable anti-inflammatory effect, and hence might be of benefit for NAFLD patients. In this study, we used a rat model of diet-induced NAFLD to examine the potential effect of metformin, pioglitazone, dapagliflozin and their combinations on NAFLD manifestations. Rats were fed an atherogenic diet containing 1.25 % cholesterol, 0.5 % cholic acid and 60 % cocoa butter for 6 weeks causing a number of metabolic and hepatic alterations including insulin resistance, dyslipidemia, systemic inflammation, increased hepatic oxidative stress and lipid peroxidation, hepatic steatosis, lobular inflammation, as well as increased markers of liver inflammation and hepatocyte apoptosis. Drug treatment, which started at the third week of NAFLD induction and continued for three weeks, not only ameliorated the observed metabolic impairment, but also functional and structural manifestations of NAFLD. Specifically, anti-diabetic drug treatment reversed markers of systemic and hepatic inflammation, oxidative stress, hepatic fibrosis, and hepatocyte apoptosis. Our findings propose that anti-diabetic drugs with a potential anti-inflammatory effect can ameliorate the manifestations of NAFLD, and thus may provide a therapeutic option for such a condition that is closely associated with metabolic diseases. The detailed pharmacology of these classes in aspects linked to the observed impact on NAFLD requires to be further investigated and translated into clinical studies for tailored therapy specifically targeting NAFLD.
C1 [Shaaban, Hager H.; El-Mallah, Ahmed; El-Yazbi, Ahmed F.] Alexandria Univ, Dept Pharmacol & Toxicol, Fac Pharm, Alexandria, Egypt.
   [Alzaim, Ibrahim] Amer Univ Beirut, Dept Biochem & Mol Genet, Fac Med, Beirut, Lebanon.
   [Alzaim, Ibrahim] Amer Univ Beirut, Dept Pharmacol & Toxicol, Fac Med, Beirut, Lebanon.
   [Aly, Rania G.] Alexandria Univ, Dept Pathol, Fac Med, Alexandria, Egypt.
   [El-Yazbi, Ahmed F.] Al Alamein Int Univ, Fac Pharm, Alamein, Egypt.
   [Wahid, Ahmed] Alexandria Univ, Dept Pharmaceut Biochem, Fac Pharm, Alexandria, Egypt.
C3 Egyptian Knowledge Bank (EKB); Alexandria University; American
   University of Beirut; American University of Beirut; Egyptian Knowledge
   Bank (EKB); Alexandria University; Alamein International University
   (AIU); Egyptian Knowledge Bank (EKB); Alexandria University
RP Shaaban, HH (corresponding author), Alexandria Univ, Dept Pharmacol & Toxicol, Fac Pharm, Alexandria, Egypt.; El-Yazbi, AF (corresponding author), Al Alamein Int Univ, Fac Pharm, Alamein, Egypt.; Wahid, A (corresponding author), Alexandria Univ, Dept Pharmaceut Biochem, Fac Pharm, Alexandria, Egypt.
EM hager.h.shaaban@alexu.edu.eg; Ahmed.fawzy.aly@alexu.edu.eg;
   ahmed.wahid@alexu.edu.eg
RI El-Yazbi, Ahmed/AAT-6837-2021; Gaber Aly, Rania/HGD-5586-2022; AlZaim,
   Ibrahim/IXD-6084-2023
OI El-Yazbi, Ahmed/0000-0003-3432-3038; Gaber, Rania/0000-0003-1227-6357;
   AlZaim, Ibrahim/0000-0001-6677-4365
FU Academic Thesis Research Fund (ATRF), Faculty of Pharmacy, Alexandria
   University
FX The research was funded by the Academic Thesis Research Fund (ATRF),
   Faculty of Pharmacy, Alexandria University
CR Adams LA, 2005, GASTROENTEROLOGY, V129, P113, DOI 10.1053/j.gastro.2005.04.014
   Akcam M, 2011, INT J VITAM NUTR RES, V81, P398, DOI 10.1024/0300-9831/a000086
   Alers S, 2012, MOL CELL BIOL, V32, P2, DOI 10.1128/MCB.06159-11
   AlZaim I, 2020, FRONT CARDIOVASC MED, V7, DOI 10.3389/fcvm.2020.602088
   Androutsakos T, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23063107
   Arai T, 2021, THER ADV ENDOCRINOL, V12, DOI 10.1177/20420188211000243
   Bajaj M, 2004, J CLIN ENDOCR METAB, V89, P200, DOI 10.1210/jc.2003-031315
   Bellentani S, 2000, ANN INTERN MED, V132, P112, DOI 10.7326/0003-4819-132-2-200001180-00004
   Birben E, 2012, WORLD ALLERGY ORGAN, V5, P9, DOI 10.1097/WOX.0b013e3182439613
   Björnsson E, 2007, SCAND J GASTROENTERO, V42, P1023, DOI 10.1080/00365520701514529
   Breckenridge DG, 2003, ONCOGENE, V22, P8608, DOI 10.1038/sj.onc.1207108
   BROUCKAERT P, 1993, IMMUNOBIOLOGY, V187, P317, DOI 10.1016/S0171-2985(11)80347-5
   Brunt EM, 2015, NAT REV DIS PRIMERS, V1, DOI 10.1038/nrdp.2015.80
   Bugianesi E, 2010, CURR PHARM DESIGN, V16, P1941, DOI 10.2174/138161210791208875
   Buzzetti E, 2016, METABOLISM, V65, P1038, DOI 10.1016/j.metabol.2015.12.012
   Cacciapuoti F, 2013, WORLD J HEPATOL, V5, P109, DOI 10.4254/wjh.v5.i3.109
   Choi DH, 2018, ENDOCRINOL METAB, V33, P387, DOI 10.3803/EnM.2018.33.3.387
   Clichici S, 2015, J MED FOOD, V18, P290, DOI 10.1089/jmf.2013.0179
   Cohen DE, 2008, J CLIN LIPIDOL, V2, pS1, DOI 10.1016/j.jacl.2008.01.004
   Colell A, 2003, J BIOL CHEM, V278, P33928, DOI 10.1074/jbc.M210943200
   Côté I, 2013, EUR J NUTR, V52, P1523, DOI 10.1007/s00394-012-0459-5
   Crespo J, 2001, HEPATOLOGY, V34, P1158, DOI 10.1053/jhep.2001.29628
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   Del Gaudio A, 2002, OBES SURG, V12, P802, DOI 10.1381/096089202320995592
   Deng W, 2017, CANCER BIOMARK, V20, P411, DOI 10.3233/CBM-170157
   Dwaib HS, 2022, MOL PHARMACOL, V102, P60, DOI 10.1124/molpharm.121.000338
   Dwaib HS, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.626313
   Elkhatib MAW, 2019, TRANSL RES, V214, P121, DOI 10.1016/j.trsl.2019.07.009
   ElMahdy MK, 2020, INT IMMUNOPHARMACOL, V86, DOI 10.1016/j.intimp.2020.106730
   Esposito K, 2004, NUTR METAB CARDIOVAS, V14, P228, DOI 10.1016/S0939-4753(04)80048-6
   Euh W, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.613389
   Fang YL, 2018, WORLD J GASTROENTERO, V24, P2974, DOI 10.3748/wjg.v24.i27.2974
   Federico A, 2006, GUT, V55, P901, DOI 10.1136/gut.2006.091967
   Feng B, 2003, NAT CELL BIOL, V5, P781, DOI 10.1038/ncb1035
   Feng D, 2019, NUTR METAB, V16, DOI 10.1186/s12986-019-0410-3
   Fernández-Galilea M, 2014, OBESITY, V22, P2210, DOI 10.1002/oby.20846
   Flora K, 1998, AM J GASTROENTEROL, V93, P139, DOI 10.1111/j.1572-0241.1998.00139.x
   Fukuda A, 2019, PATHOL RES PRACT, V215, DOI 10.1016/j.prp.2019.152599
   Gao B, 2016, GASTROENTEROLOGY, V150, P1704, DOI 10.1053/j.gastro.2016.01.025
   Ghatei N, 2017, IRAN J BASIC MED SCI, V20, P1037, DOI 10.22038/IJBMS.2017.9273
   Gillessen A, 2020, ADV THER, V37, P1279, DOI 10.1007/s12325-020-01251-y
   Gloire G, 2006, BIOCHEM PHARMACOL, V72, P1493, DOI 10.1016/j.bcp.2006.04.011
   Greco D, 2008, AM J PHYSIOL-GASTR L, V294, pG1281, DOI 10.1152/ajpgi.00074.2008
   Hammoud SH, 2021, BIOCHEM PHARMACOL, V186, DOI 10.1016/j.bcp.2021.114491
   Hardwick RN, 2010, DRUG METAB DISPOS, V38, P2293, DOI 10.1124/dmd.110.035006
   Hardy T, 2016, ANNU REV PATHOL-MECH, V11, P451, DOI 10.1146/annurev-pathol-012615-044224
   Hasanvand A, 2022, INFLAMMOPHARMACOLOGY, V30, P775, DOI 10.1007/s10787-022-00980-6
   He L, 2009, CELL, V137, P635, DOI 10.1016/j.cell.2009.03.016
   Honda Y, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0146337
   Huang DIQ, 2021, NAT REV GASTRO HEPAT, V18, P223, DOI 10.1038/s41575-020-00381-6
   Jojima T, 2016, DIABETOL METAB SYNDR, V8, DOI 10.1186/s13098-016-0169-x
   Kainuma M, 2006, J GASTROENTEROL, V41, P971, DOI 10.1007/s00535-006-1883-1
   Kaplan A, 2018, HEART FAIL REV, V23, P419, DOI 10.1007/s10741-017-9665-9
   Khalaf HM, 2019, CLIN EXP HEPATOL, V5, P65, DOI 10.5114/ceh.2019.83159
   Koek GH, 2011, CLIN CHIM ACTA, V412, P1297, DOI 10.1016/j.cca.2011.04.013
   LETTERON P, 1990, BIOCHEM PHARMACOL, V39, P2027, DOI 10.1016/0006-2952(90)90625-U
   Li LR, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.589273
   Lluis JM, 2003, GASTROENTEROLOGY, V124, P708, DOI 10.1053/gast.2003.50089
   Loomba R, 2009, ALIMENT PHARM THER, V29, P172, DOI 10.1111/j.1365-2036.2008.03869.x
   Malhi H, 2008, GASTROENTEROLOGY, V134, P1641, DOI 10.1053/j.gastro.2008.03.002
   Manco M, 2017, CHILDREN-BASEL, V4, DOI 10.3390/children4080074
   Manne V, 2018, CLIN LIVER DIS, V22, P23, DOI 10.1016/j.cld.2017.08.007
   Mantovani A, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22052350
   Marí M, 2006, CELL METAB, V4, P185, DOI 10.1016/j.cmet.2006.07.006
   Matsuzawa N, 2007, HEPATOLOGY, V46, P1392, DOI 10.1002/hep.21874
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Nakano S, 2015, J CLIN EXP HEPATOL, V5, P190, DOI 10.1016/j.jceh.2015.02.005
   Nobili V, 2005, CLIN CHIM ACTA, V355, P105, DOI 10.1016/j.cccn.2004.12.022
   Ozsurekci Y, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/2768365
   Parasuraman S, 2010, J PHARMACOL PHARMACO, V1, P87, DOI 10.4103/0976-500X.72350
   Parthasarathy G, 2020, HEPATOL COMMUN, V4, P478, DOI 10.1002/hep4.1479
   Paschos P, 2009, HIPPOKRATIA, V13, P9
   Pfützner A, 2005, HORM METAB RES, V37, P510, DOI 10.1055/s-870320
   Qiang S, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/s13098-015-0102-8
   Rafeh R, 2020, CLIN SCI, V134, P827, DOI 10.1042/CS20190227
   Rakoski MO, 2010, ALIMENT PHARM THER, V32, P1211, DOI 10.1111/j.1365-2036.2010.04467.x
   Ramos CAF, 2015, TOXICOL REP, V2, P482, DOI 10.1016/j.toxrep.2015.01.001
   Raza S, 2021, FRONT BIOSCI-LANDMRK, V26, P206, DOI 10.2741/4892
   Saha AK, 2004, BIOCHEM BIOPH RES CO, V314, P580, DOI 10.1016/j.bbrc.2003.12.120
   Salminen A, 2011, J MOL MED, V89, P667, DOI 10.1007/s00109-011-0748-0
   Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929
   Seki E, 2007, NAT MED, V13, P1324, DOI 10.1038/nm1663
   Shaker E, 2010, FOOD CHEM TOXICOL, V48, P803, DOI 10.1016/j.fct.2009.12.011
   Shen L, 2003, WORLD J GASTROENTERO, V9, P1106
   Shimizu M, 2019, DIABETES OBES METAB, V21, P285, DOI 10.1111/dom.13520
   Shyangdan D, 2011, HEALTH TECHNOL ASSES, V15, P1, DOI 10.3310/hta15380
   Sies H, 2015, REDOX BIOL, V4, P180, DOI 10.1016/j.redox.2015.01.002
   Surapaneni KM, 2014, J PHYSIOL PHARMACOL, V65, P67
   Tacelli M, 2018, PHARMACEUTICALS-BASE, V11, DOI 10.3390/ph11040121
   Tahara A, 2014, J PHARM PHARMACOL, V66, P975, DOI 10.1111/jphp.12223
   Tahara A, 2013, EUR J PHARMACOL, V715, P246, DOI 10.1016/j.ejphar.2013.05.014
   Takahashi H, 2022, HEPATOL COMMUN, V6, P120, DOI 10.1002/hep4.1696
   Tannock LR, 2005, CIRCULATION, V111, P3058, DOI 10.1161/CIRCULATIONAHA.104.506188
   Teratani T, 2012, GASTROENTEROLOGY, V142, P152, DOI 10.1053/j.gastro.2011.09.049
   Tiikkainen M, 2004, DIABETES, V53, P2169, DOI 10.2337/diabetes.53.8.2169
   Tobita H, 2017, CURR THER RES CLIN E, V87, P13, DOI 10.1016/j.curtheres.2017.07.002
   Tous M, 2006, BIOCHEM BIOPH RES CO, V340, P1078, DOI 10.1016/j.bbrc.2005.12.109
   Tsai KF, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10081166
   Tsuchida T, 2017, NAT REV GASTRO HEPAT, V14, P397, DOI 10.1038/nrgastro.2017.38
   Uchil Deepa, 2009, J Assoc Physicians India, V57, P201
   UCHIYAMA M, 1978, ANAL BIOCHEM, V86, P271, DOI 10.1016/0003-2697(78)90342-1
   Vallim TQD, 2013, CELL METAB, V17, P657, DOI 10.1016/j.cmet.2013.03.013
   van der Veen JN, 2016, AM J PHYSIOL-GASTR L, V310, pG526, DOI 10.1152/ajpgi.00243.2015
   Vargas-Mendoza N, 2014, WORLD J HEPATOL, V6, P144, DOI 10.4254/wjh.v6.i3.144
   Vergnes L, 2003, J BIOL CHEM, V278, P42774, DOI 10.1074/jbc.M306022200
   Vernon G, 2011, ALIMENT PHARM THER, V34, P274, DOI 10.1111/j.1365-2036.2011.04724.x
   Wang W, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076538
   Wang Y, 2013, EXP THER MED, V6, P77, DOI 10.3892/etm.2013.1090
   Wouters K, 2008, HEPATOLOGY, V48, P474, DOI 10.1002/hep.22363
   Xu ZJ, 2010, DIGEST DIS SCI, V55, P931, DOI 10.1007/s10620-009-0815-3
   Yamauchi T, 2002, NAT MED, V8, P1288, DOI 10.1038/nm788
   Zhang EX, 2021, HEPATOL COMMUN, V5, P736, DOI 10.1002/hep4.1611
   Zhang W, 2013, DIGEST DIS SCI, V58, P3198, DOI 10.1007/s10620-013-2775-x
NR 113
TC 22
Z9 23
U1 3
U2 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD NOV 1
PY 2022
VL 308
AR 120956
DI 10.1016/j.lfs.2022.120956
PG 14
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 7Q6WX
UT WOS:000909530600001
PM 36103959
DA 2025-06-11
ER

PT J
AU Waye, MMY
AF Waye, Mary Miu Yee
TI New insights into how adenovirus might lead to obesity: An oxidative
   stress theory
SO FREE RADICAL RESEARCH
LA English
DT Review
DE Adenovirus 36; oxidation; metabolic syndrome; anti-oxidant; infection
ID SKELETAL-MUSCLE CELLS; IGF-I ACTIVITY; HELICOBACTER-PYLORI; GENE
   POLYMORPHISMS; GLUCOSE-UPTAKE; ASSOCIATION; INFECTION; RESVERATROL;
   ANTIOXIDANT; ADIPOSITY
AB Obesity has become a worldwide epidemic that leads to many serious weight-related disorders. Recently, infection by viruses has been proposed as a possible cause of the obesity epidemic. Of the many viruses screened, adenovirus 36 has been found to be a strong candidate virus that is associated with obesity, based on evidence in various model systems as well as clinical data. The mechanism of how the adenovirus could lead to obesity is not known and this paper proposes some new insights into how oxidative stress could be a possible mechanism of how adenovirus might lead to obesity. This paper reviews the relevant literature of both the effect of adenovirus on cells' anti-oxidant response and the link between obesity and oxidative stress.
C1 Chinese Univ Hong Kong, Croucher Lab Human Genom, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong
RP Waye, MMY (corresponding author), Chinese Univ Hong Kong, Croucher Lab Human Genom, Sch Biomed Sci, MMW Bldg,Rm 608, Shatin, Hong Kong, Peoples R China.
EM mary-waye@cuhk.edu.hk
RI 韋妙宜教授, Mary/A-9674-2008
OI Waye, Mary Miu Yee/0000-0002-2582-4917
FU Food and Health Bureau; Research Fund for the Control of Infectious
   Diseases of Hong Kong
FX The author wishes to thank the Food and Health Bureau and the Research
   Fund for the Control of Infectious Diseases of Hong Kong for financial
   Support. The author reports no conflicts of interest. The author alone
   is responsible for the content and writing of the paper.
CR Ando K, 2008, NUCLEIC ACIDS RES, V36, P4327, DOI 10.1093/nar/gkn416
   Atkinson RL, 2007, MAYO CLIN PROC, V82, P1192, DOI 10.4065/82.10.1192
   Atkinson RL, 2011, OBESITY, V19, P2, DOI 10.1038/oby.2010.107
   Atkinson RL, 2010, INT J PEDIATR OBES, V5, P157, DOI 10.3109/17477160903111789
   Atkinson RL, 2005, INT J OBESITY, V29, P281, DOI 10.1038/sj.ijo.0802830
   Barlan AU, 2011, J VIROL, V85, P146, DOI 10.1128/JVI.01265-10
   Baur JA, 2006, NATURE, V444, P337, DOI 10.1038/nature05354
   Beher D, 2009, CHEM BIOL DRUG DES, V74, P619, DOI 10.1111/j.1747-0285.2009.00901.x
   Blaser MJ, 2010, GASTROENTEROLOGY, V139, P1819, DOI 10.1053/j.gastro.2010.10.037
   Broderick MP, 2010, INT J OBESITY, V34, P302, DOI 10.1038/ijo.2009.224
   CARTER JK, 1983, INFECT IMMUN, V39, P410, DOI 10.1128/IAI.39.1.410-422.1983
   Chaturvedi R, 2010, J BIOL CHEM, V285, P30389, DOI 10.1074/jbc.M110.135251
   CHRISTENSEN D, 1999, IS YOUR STOMACH BUGG
   Chrysohoou C, 2007, NUTR METAB CARDIOVAS, V17, P590, DOI 10.1016/j.numecd.2006.05.007
   De Jong JC, 1999, J CLIN MICROBIOL, V37, P3940, DOI 10.1128/JCM.37.12.3940-3945.1999
   Dhurandhar N.V., 1990, J BOMBAY VET COLL, V2, P131
   Dhurandhar NV, 2001, INT J OBESITY, V25, P990, DOI 10.1038/sj.ijo.0801668
   Dhurandhar NV, 2002, J NUTR, V132, P3155, DOI 10.1093/jn/131.10.3155
   Dhurandhar NV, 2000, INT J OBESITY, V24, P989, DOI 10.1038/sj.ijo.0801319
   Dillingham B.L., 2009, Int JNM, V4, P23
   Duffy AM, 2010, METHODS MOL BIOL, V594, P381, DOI 10.1007/978-1-60761-411-1_27
   Echavarría M, 2008, CLIN MICROBIOL REV, V21, P704, DOI 10.1128/CMR.00052-07
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gabbert CC, 2009, OBESITY, V17, pS60
   GOMPF SG, 2010, ADENOVIRUSES
   Goossens VJ, 2011, OBESITY, V19, P3, DOI 10.1038/oby.2010.108
   Goossens VJ, 2011, OBESITY, V19, P220, DOI 10.1038/oby.2009.452
   Hsu CL, 2010, J AGR FOOD CHEM, V58, P2150, DOI 10.1021/jf903557c
   HUNT M, 2000, MICROBIOL IMMUNOL, pCH3
   Icyuz M, 2009, TRANSPLANTATION, V87, P821, DOI 10.1097/TP.0b013e318199c686
   Imamura S, 2010, J GASTROEN HEPATOL, V25, P1244, DOI 10.1111/j.1440-1746.2010.06307.x
   Inberg A, 2010, J BIOL CHEM, V285, P25686, DOI 10.1074/jbc.M110.109751
   KIM YS, 1987, J INFECT DIS, V156, P402, DOI 10.1093/infdis/156.2.402
   Kolesar JM, 2000, J CHROMATOGR B, V744, P1, DOI 10.1016/S0378-4347(00)00219-X
   Lenzen S, 2008, BIOCHEM SOC T, V36, P343, DOI 10.1042/BST0360343
   Leong CW, 2007, BIOCHEM BIOPH RES CO, V360, P173, DOI 10.1016/j.bbrc.2007.06.025
   Li S, 2009, ONCOGENE, V28, P390, DOI 10.1038/onc.2008.393
   Lonn E, 2005, JAMA-J AM MED ASSOC, V293, P1338, DOI 10.1001/jama.293.11.1338
   LYONS MJ, 1982, SCIENCE, V216, P82, DOI 10.1126/science.7038878
   McCarty MF, 2010, MED HYPOTHESES, V74, P18, DOI 10.1016/j.mehy.2009.04.052
   Mendall MA, 1998, BRIT MED J, V316, P953, DOI 10.1136/bmj.316.7136.953
   Mong JLY, 2009, INT J OBESITY, V33, P1446, DOI 10.1038/ijo.2009.186
   Mong JLY, 2010, CLIN ENDOCRINOL, V73, P313, DOI 10.1111/j.1365-2265.2010.03786.x
   Na HN, 2010, INT J OBESITY, V34, P89, DOI 10.1038/ijo.2009.207
   Nam JK, 2010, J GENE MED, V12, P453, DOI 10.1002/jgm.1457
   NARAYAN O, 1983, SCIENCE, V220, P1401, DOI 10.1126/science.6602380
   Pacholec M, 2010, J BIOL CHEM, V285, P8340, DOI 10.1074/jbc.M109.088682
   PENCHEV GI, 2011, RES VET SCI, V90, P196, DOI DOI 10.1016/J.RVSC.2010.05.023
   Perry S, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008804
   Pickup JC, 2004, DIABETES CARE, V27, P813, DOI 10.2337/diacare.27.3.813
   Ristow M, 2009, P NATL ACAD SCI USA, V106, P8665, DOI 10.1073/pnas.0903485106
   Rogers PM, 2008, INT J OBESITY, V32, P397, DOI 10.1038/sj.ijo.0803748
   Rogers PM, 2008, DIABETES, V57, P2321, DOI 10.2337/db07-1311
   Salehian B, 2010, EMERG INFECT DIS, V16, P850, DOI 10.3201/eid1605.091271
   So PW, 2005, INT J OBESITY, V29, P603, DOI 10.1038/sj.ijo.0802917
   Speliotes EK, 2010, NAT GENET, V42, P937, DOI 10.1038/ng.686
   Trovato GM, 2009, INT J OBESITY, V33, P1402, DOI 10.1038/ijo.2009.196
   Trovato GM, 2010, LIVER INT, V30, P184, DOI 10.1111/j.1478-3231.2009.02127.x
   Vangipuram SD, 2007, INT J OBESITY, V31, P87, DOI 10.1038/sj.ijo.0803366
   Vangipuram SD, 2004, OBES RES, V12, P770, DOI 10.1038/oby.2004.93
   Vasilakopoulou A, 2007, INT J OBESITY, V31, P1350, DOI 10.1038/sj.ijo.0803623
   Vincent HK, 2006, OBESITY, V14, P2224, DOI 10.1038/oby.2006.261
   Walsh MP, 2010, J CLIN MICROBIOL, V48, P991, DOI 10.1128/JCM.01694-09
   Wang YF, 2008, OBESITY, V16, P2323, DOI 10.1038/oby.2008.351
   Wang ZQ, 2010, INT J OBESITY, V34, P1355, DOI 10.1038/ijo.2010.77
   Wang ZQ, 2008, DIABETES, V57, P1805, DOI 10.2337/db07-1313
   Waye MMY, 2010, PHARMACEUTICALS-BASE, V3, P3343, DOI 10.3390/ph3103343
   Willer CJ, 2008, NAT GENET, V40, P161, DOI 10.1038/ng.76
   Zhang HJ, 2002, J VIROL, V76, P355, DOI 10.1128/JVI.76.1.355-363.2002
   Zuin A, 2010, AGING-US, V2, P231, DOI 10.18632/aging.100133
NR 70
TC 7
Z9 7
U1 1
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PD AUG
PY 2011
VL 45
IS 8
BP 880
EP 887
DI 10.3109/10715762.2011.571684
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 790CJ
UT WOS:000292565800003
PM 21615271
DA 2025-06-11
ER

PT J
AU Kampoli, AM
   Tousoulis, D
   Briasoulis, A
   Latsios, G
   Papageorgiou, N
   Stefanadis, C
AF Kampoli, Anna-Maria
   Tousoulis, Dimitris
   Briasoulis, Alexandros
   Latsios, George
   Papageorgiou, Nikolaos
   Stefanadis, Christodoulos
TI Potential Pathogenic Inflammatory Mechanisms of Endothelial Dysfunction
   Induced by Type 2 Diabetes Mellitus
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Inflammation; diabetes mellitus; atherosclerosis
ID NITRIC-OXIDE SYNTHASE; C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA;
   ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE; MYOCARDIAL-INFARCTION;
   METABOLIC SYNDROME; OXIDATIVE STRESS; PROGENITOR CELLS; VITAMIN-C
AB Insulin resistance and the vascular complications of diabetes include activation of the inflammation cascade, endothelial dysfunction, and oxidative stress. The comorbidities of diabetes, namely obesity, insulin resistance, hyperglycemia, hypertension and dyslipidemia collectively aggravate these processes while antihyperglycemic interventions tend to correct them. Increased C-reactive protein, interleukin 6, tumor necrosis factor alpha and especially interstitial cellular adhesion molecule-1, vascular cellular adhesion molecule-1, and E-selectin are associated with cardiovascular and non-cardiovascular complications of both type 1 and type 2 diabetes. We sought to review the clinical implications of the inflammation theory, including the relevance of inflammation markers as predictors of type 2 diabetes in clinical studies, and the potential treatments of diabetes, inferred from the pathophysiology.
C1 [Kampoli, Anna-Maria; Tousoulis, Dimitris; Briasoulis, Alexandros; Latsios, George; Papageorgiou, Nikolaos; Stefanadis, Christodoulos] Univ Athens, Sch Med, Cardiol Unit 1, Hippokrat Hosp, GR-11527 Athens, Greece.
C3 National & Kapodistrian University of Athens; Hippokration General
   Hospital; Athens Medical School
RP Kampoli, AM (corresponding author), Univ Athens, Sch Med, Cardiol Unit 1, Hippokrat Hosp, GR-11527 Athens, Greece.
EM kampoliannamaria@yahoo.gr
RI PAPAGEORGIOU MD PhD, NIKOLAOS/AFV-3660-2022; Briasoulis,
   Alexandros/AAD-3965-2019; Stefanadis, Christodoulos/ABH-2232-2020
OI Briasoulis, Alexandros/0000-0002-5740-9670; Stefanadis,
   Christodoulos/0000-0001-5974-6454; Papageorgiou,
   Nikolaos/0000-0002-2063-2510
CR Alderton WK, 2001, BIOCHEM J, V357, P593, DOI 10.1042/0264-6021:3570593
   Alp NJ, 2003, J CLIN INVEST, V112, P725, DOI 10.1172/JCI200317786
   Antoniades C, 2004, DIABETIC MED, V21, P552, DOI 10.1111/j.1464-5491.2004.01201.x
   Antoniades C, 2007, CLIN CARDIOL, V30, P295, DOI 10.1002/clc.20101
   Antuna-Puente B, 2008, DIABETES METAB, V34, P2, DOI 10.1016/j.diabet.2007.09.004
   Aversa A, 2008, DIABETIC MED, V25, P37, DOI 10.1111/j.1464-5491.2007.02298.x
   Balletshofer BM, 2000, CIRCULATION, V101, P1780, DOI 10.1161/01.CIR.101.15.1780
   Bastard JP, 2006, EUR CYTOKINE NETW, V17, P4
   BATH PMW, 1991, ARTERIOSCLER THROMB, V11, P254, DOI 10.1161/01.ATV.11.2.254
   Beckman JA, 2003, AM J PHYSIOL-HEART C, V285, pH2392, DOI 10.1152/ajpheart.00403.2003
   Beckman JA, 2002, CIRC RES, V90, P107, DOI 10.1161/hh0102.102359
   Beckman JA, 2010, J CLIN ENDOCR METAB, V95, P3783, DOI 10.1210/jc.2010-0286
   Betteridge DJ, 2007, AM J CARDIOL, V100, P1245, DOI 10.1016/j.amjcard.2007.05.044
   Blanco-Colio LM, 2007, AM HEART J, V153, P881, DOI 10.1016/j.ahj.2007.02.029
   Böger CA, 2005, KIDNEY INT, V68, P217, DOI 10.1111/j.1523-1755.2005.00396.x
   Böni-Schnetzler M, 2008, J CLIN ENDOCR METAB, V93, P4065, DOI 10.1210/jc.2008-0396
   Braga MFB, 2009, AM J CARDIOL, V104, P835, DOI 10.1016/j.amjcard.2009.05.015
   Brand MD, 2004, FREE RADICAL BIO MED, V37, P755, DOI 10.1016/j.freeradbiomed.2004.05.034
   Cai DS, 2005, NAT MED, V11, P183, DOI 10.1038/nm1166
   Cardozo AK, 2005, DIABETES, V54, P452, DOI 10.2337/diabetes.54.2.452
   Chang JL, 2010, DIABETES, V59, P2949, DOI 10.2337/db10-0582
   Chen JF, 2010, MOL CELL BIOCHEM, V335, P137, DOI 10.1007/s11010-009-0250-y
   Chen K, 2004, J BIOL CHEM, V279, P35079, DOI 10.1074/jbc.M404859200
   Chen Q, 2009, BIOCHEM BIOPH RES CO, V381, P192, DOI 10.1016/j.bbrc.2009.02.040
   Chilton R, 2011, AM J MED, V124, pS35, DOI 10.1016/j.amjmed.2010.11.004
   Clarkson P, 1996, J AM COLL CARDIOL, V28, P573, DOI 10.1016/0735-1097(96)82380-1
   Darley-Usmar V, 2004, FREE RADICAL BIO MED, V37, P753, DOI 10.1016/j.freeradbiomed.2004.05.026
   Kater ALD, 2010, METABOLISM, V59, P921, DOI 10.1016/j.metabol.2010.02.011
   Derosa G, 2010, HORM METAB RES, V42, P663, DOI 10.1055/s-0030-1255036
   Desrois M, 2010, AM J PHYSIOL-HEART C, V299, pH1679, DOI 10.1152/ajpheart.00998.2009
   Dimmeler S, 1999, NATURE, V399, P601, DOI 10.1038/21224
   Dobarro D., 2009, Cardiovascular & Hematological Agents in Medicinal Chemistry, V7, P212
   Donath MY, 2011, NAT REV IMMUNOL, V11, P98, DOI 10.1038/nri2925
   Duchen MR, 2004, DIABETES, V53, pS96, DOI 10.2337/diabetes.53.2007.S96
   Duncan ER, 2008, DIABETES, V57, P3307, DOI 10.2337/db07-1111
   Dursun H, 2007, ACTA DIABETOL, V44, P1, DOI 10.1007/s00592-007-0233-y
   Etoh T, 2003, DIABETOLOGIA, V46, P1428, DOI 10.1007/s00125-003-1205-6
   Federici M, 2004, CIRCULATION, V109, P399, DOI 10.1161/01.CIR.0000109498.77895.6F
   FEINSTEIN R, 1993, J BIOL CHEM, V268, P26055
   Fève B, 2009, NAT REV ENDOCRINOL, V5, P305, DOI 10.1038/nrendo.2009.62
   Ford ES, 1999, DIABETES CARE, V22, P1971, DOI 10.2337/diacare.22.12.1971
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   García-Cardeña G, 1998, NATURE, V392, P821, DOI 10.1038/33934
   GARG UC, 1989, J CLIN INVEST, V83, P1774, DOI 10.1172/JCI114081
   Geisler T, 2010, CLIN RES CARDIOL, V99, P743, DOI 10.1007/s00392-010-0179-x
   Ghanim H, 2007, DIABETOLOGIA, V50, P278, DOI 10.1007/s00125-006-0508-9
   Gordin D, 2008, ANN MED, V40, P627, DOI 10.1080/07853890802126547
   GRAY RP, 1993, BRIT HEART J, V70, P530
   Gupte S, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011800
   Hamdy NM, 2009, J DIABETES COMPLICAT, V23, P167, DOI 10.1016/j.jdiacomp.2007.10.006
   Hamed S, 2010, THROMB RES, V126, P166, DOI 10.1016/j.thromres.2010.03.002
   Hartell NA, 2005, BIOCHEM PHARMACOL, V69, P781, DOI 10.1016/j.bcp.2004.11.022
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Hovens MMC, 2008, DIABETES OBES METAB, V10, P668, DOI 10.1111/j.1463-1326.2007.00794.x
   Hsueh WA, 2004, AM J MED, V117, P109, DOI 10.1016/j.amjmed.2004.02.042
   Hsueh WA., 2003, Am J Cardiol, V92, p10J17J
   Hu FB, 2004, DIABETES, V53, P693, DOI 10.2337/diabetes.53.3.693
   Hu Y, 2009, DIABETES VASC DIS RE, V6, P262, DOI 10.1177/1479164109339966
   IGNARRO LJ, 1991, BLOOD VESSELS, V28, P67
   IGNARRO LJ, 1990, ANNU REV PHARMACOL, V30, P535, DOI 10.1146/annurev.pa.30.040190.002535
   Jain SK, 2010, MOL NUTR FOOD RES, V54, P1371, DOI 10.1002/mnfr.200900177
   Jankovec Z, 2009, WIEN KLIN WOCHENSCHR, V121, P459, DOI 10.1007/s00508-009-1203-x
   Jiang ZY, 1999, J CLIN INVEST, V104, P447, DOI 10.1172/JCI5971
   Kashyap SR, 2010, METAB SYNDR RELAT D, V8, P459, DOI 10.1089/met.2010.0018
   Kim F, 2007, CIRC RES, V100, P1589, DOI 10.1161/CIRCRESAHA.106.142851
   KNOWLES RG, 1994, BIOCHEM J, V298, P249, DOI 10.1042/bj2980249
   Krumenacker J, 2004, BRAIN RES BULL, V62, P505, DOI 10.1016/S0361-9230(03)00102-3
   Krysiak R, 2011, AM J CARDIOL    0126
   KUBES P, 1991, P NATL ACAD SCI USA, V88, P4651, DOI 10.1073/pnas.88.11.4651
   Kuboki K, 2000, CIRCULATION, V101, P676, DOI 10.1161/01.CIR.101.6.676
   Larsen CM, 2007, NEW ENGL J MED, V356, P1517, DOI 10.1056/NEJMoa065213
   Lee KM, 2009, ATHEROSCLEROSIS, V207, P391, DOI 10.1016/j.atherosclerosis.2009.06.016
   Leinonen E, 2003, ATHEROSCLEROSIS, V166, P387, DOI 10.1016/S0021-9150(02)00371-4
   Lin CW, 2010, DIABETES RES CLIN PR, V90, P167, DOI 10.1016/j.diabres.2010.08.002
   Liu YP, 2003, CIRC RES, V93, P573, DOI 10.1161/01.RES.0000091261.19387.AE
   Makimattila S, 1996, CIRCULATION, V94, P1276, DOI 10.1161/01.CIR.94.6.1276
   Manning PJ, 2004, DIABETES CARE, V27, P2509, DOI 10.2337/diacare.27.10.2509
   MARLETTA MA, 1994, CELL, V78, P927, DOI 10.1016/0092-8674(94)90268-2
   Mehta NN, 2009, CARDIOVASC DRUG THER, V23, P17, DOI 10.1007/s10557-008-6144-5
   Michel JB, 1997, J BIOL CHEM, V272, P15583, DOI 10.1074/jbc.272.25.15583
   Milne JC, 2007, NATURE, V450, P712, DOI 10.1038/nature06261
   MONCADA S, 1991, PHARMACOL REV, V43, P109
   Montagnani M, 2002, J BIOL CHEM, V277, P1794, DOI 10.1074/jbc.M103728200
   Montagnani M, 2001, J BIOL CHEM, V276, P30392, DOI 10.1074/jbc.M103702200
   Muniyappa R, 2007, ENDOCR REV, V28, P463, DOI 10.1210/er.2007-0006
   Nacci C, 2009, INTERN EMERG MED, V4, P107, DOI 10.1007/s11739-009-0234-7
   NAKAKI T, 1990, EUR J PHARM-MOLEC PH, V189, P347, DOI 10.1016/0922-4106(90)90031-R
   Nakanishi S, 2003, DIABETES CARE, V26, P2754, DOI 10.2337/diacare.26.10.2754
   Nakano S, 2010, J ATHEROSCLER THROMB, V17, P410, DOI 10.5551/jat.1891
   Nyström T, 2006, CLIN SCI, V110, P673, DOI 10.1042/CS20050353
   Oliveira Paulo J, 2002, Rev Port Cardiol, V21, P759
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Paiva MSM, 2008, J INTERV CARDIOL, V21, P403, DOI 10.1111/j.1540-8183.2008.00385.x
   Palsamy P, 2010, CHEM-BIOL INTERACT, V186, P200, DOI 10.1016/j.cbi.2010.03.028
   Pecoits-Filho R, 2002, NEPHROL DIAL TRANSPL, V17, P1684, DOI 10.1093/ndt/17.9.1684
   Pickup JC, 1997, DIABETOLOGIA, V40, P1286, DOI 10.1007/s001250050822
   Pieper GM, 1997, J CARDIOVASC PHARM, V29, P8, DOI 10.1097/00005344-199701000-00002
   Pirot P, 2006, DIABETOLOGIA, V49, P1229, DOI 10.1007/s00125-006-0214-7
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Pu LJ, 2006, CARDIOVASC DIABETOL, V5, DOI 10.1186/1475-2840-5-27
   Quagliaro L, 2005, ATHEROSCLEROSIS, V183, P259, DOI 10.1016/j.atherosclerosis.2005.03.015
   Quiñones MJ, 2004, ANN INTERN MED, V140, P700, DOI 10.7326/0003-4819-140-9-200405040-00009
   RADOMSKI MW, 1990, P NATL ACAD SCI USA, V87, P5193, DOI 10.1073/pnas.87.13.5193
   Rajagopalan S, 1996, CIRCULATION, V94, P240, DOI 10.1161/01.CIR.94.3.240
   Ramachandran A, 2002, FREE RADICAL BIO MED, V33, P1465, DOI 10.1016/S0891-5849(02)01142-5
   Rizzuto Rosario, 2002, Trends in Pharmacological Sciences, V23, P348, DOI 10.1016/S0165-6147(02)02063-1
   Rubio-Guerra AF, 2008, CLIN EXP HYPERTENS, V30, P682, DOI 10.1080/10641960802251941
   Saely CH, 2008, CLIN CHIM ACTA, V396, P18, DOI 10.1016/j.cca.2008.06.015
   Sanchez-Zamora Y, 2010, FASEB J, V24, P2583, DOI 10.1096/fj.09-147066
   Schnell O, 2010, DIABETES VASC DIS RE, V7, P225, DOI 10.1177/1479164110372641
   Shaul PW, 1996, J BIOL CHEM, V271, P6518, DOI 10.1074/jbc.271.11.6518
   Shen GX, 2010, CAN J PHYSIOL PHARM, V88, P241, DOI 10.1139/Y10-018
   Shi Y, 2009, J DIABETES, V1, P151, DOI 10.1111/j.1753-0407.2009.00030.x
   Sobel BE, 2005, CORONARY ARTERY DIS, V16, P31, DOI 10.1097/00019501-200502000-00006
   Spranger J, 2003, DIABETES, V52, P812, DOI 10.2337/diabetes.52.3.812
   Tabit CE, 2010, REV ENDOCR METAB DIS, V11, P61, DOI 10.1007/s11154-010-9134-4
   TANG SB, 1994, BRIT J OPHTHALMOL, V78, P370, DOI 10.1136/bjo.78.5.370
   Tousoulis D, 2003, DIABETES CARE, V26, P2749, DOI 10.2337/diacare.26.10.2749
   Tousoulis D, 2007, HEART, V93, P244, DOI 10.1136/hrt.2006.093112
   Tousoulis D, 2006, ENDOTHELIUM-J ENDOTH, V13, P411, DOI 10.1080/10623320601061714
   Tousoulis D, 2010, EXPERT OPIN INV DRUG, V19, P1395, DOI 10.1517/13543784.2010.522989
   TSAO PS, 1994, CIRCULATION, V89, P2176, DOI 10.1161/01.CIR.89.5.2176
   van Doorn M, 2006, BRIT J CLIN PHARMACO, V62, P391, DOI 10.1111/j.1365-2125.2005.02532.x
   Vásquez-Vivar J, 1998, P NATL ACAD SCI USA, V95, P9220, DOI 10.1073/pnas.95.16.9220
   Vicent D, 2003, J CLIN INVEST, V111, P1373, DOI 10.1172/JCI200315211
   Wago T, 2010, HYPERTENS RES, V33, P796, DOI 10.1038/hr.2010.107
   Weng CM, 2010, HEART VESSELS, V25, P386, DOI 10.1007/s00380-009-1218-2
   Wheatcroft SB, 2003, DIABETIC MED, V20, P255, DOI 10.1046/j.1464-5491.2003.00869.x
   Wheatcroft SB, 2004, DIABETES, V53, P2645, DOI 10.2337/diabetes.53.10.2645
   Woodman RJ, 2002, ATHEROSCLEROSIS, V163, P175, DOI 10.1016/S0021-9150(01)00770-5
   Yang SNY, 2010, J DIABETES, V2, P233, DOI 10.1111/j.1753-0407.2010.00089.x
   Yasuda K, 2002, CLIN EXP PHARMACOL P, V29, P1001, DOI 10.1046/j.1440-1681.2002.03757.x
   Zeng GY, 2000, CIRCULATION, V101, P1539, DOI 10.1161/01.CIR.101.13.1539
   Zorena K, 2008, SCAND J IMMUNOL, V67, P204, DOI 10.1111/j.1365-3083.2007.02054.x
   Zou MH, 2004, J BIOL CHEM, V279, P43940, DOI 10.1074/jbc.M404421200
NR 136
TC 67
Z9 72
U1 0
U2 9
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD DEC
PY 2011
VL 17
IS 37
BP 4147
EP 4158
DI 10.2174/138161211798764825
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 941AX
UT WOS:000303935300006
PM 22204375
DA 2025-06-11
ER

PT J
AU Dube, L
   Spahis, S
   Lachaine, K
   Lemieux, A
   Monhem, H
   Poulin, SM
   Randoll, C
   Travaillaud, E
   Ould-Chikh, NE
   Marcil, V
   Delvin, E
   Levy, E
AF Dube, Laurent
   Spahis, Schohraya
   Lachaine, Karelle
   Lemieux, Andreanne
   Monhem, Hanine
   Poulin, Sarah-Maude
   Randoll, Carolane
   Travaillaud, Eva
   Ould-Chikh, Nour-El-Houda
   Marcil, Valerie
   Delvin, Edgard
   Levy, Emile
TI Specialized Pro-Resolving Mediators Derived from N-3 Polyunsaturated
   Fatty Acids: Role in Metabolic Syndrome and Related Complications
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
DE pro-resolving lipid mediators; fatty acids; metabolism; oxidative
   stress; inflammation; microbiota
ID INTESTINAL ALKALINE-PHOSPHATASE; ASPIRIN-TRIGGERED LIPOXINS; INDUCED
   INSULIN-RESISTANCE; CORD SYNAPTIC PLASTICITY; EICOSAPENTAENOIC ACID;
   LIPID MEDIATORS; MARESIN 1; DOCOSAHEXAENOIC ACID; OXIDATIVE STRESS;
   ANTIINFLAMMATORY ACTIONS
AB Significance: Metabolic syndrome (MetS) prevalence continues to grow and represents a serious public health issue worldwide. This multifactorial condition carries the risk of hastening the development of type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD), and cardiovascular diseases (CVD). Another troubling aspect of MetS is the requirement of poly-pharmacological therapy not devoid of side effects. Therefore, there is an urgent need for prospecting alternative nutraceuticals as effective therapeutic agents for MetS.Recent Advances: Currently, there is an increased interest in understanding the regulation of metabolic derangements by specialized pro-resolving lipid mediators (SPMs), especially those derived from the long chain n-3 polyunsaturated fatty acids.Critical Issues: The SPMs are recognized as efficient modulators that are capable of inhibiting the production of pro-inflammatory cytokines, blocking neutrophil activation/recruitment, and inducing non-phlogistic (anti-inflammatory) activation of macrophage engulfment and removal of apoptotic inflammatory cells and debris. The aim of the present review is precisely to first underline key concepts relative to SPM functions before focusing on their status and actions on MetS components (e.g., obesity, glucose dysmetabolism, hyperlipidemia, hypertension) and complications such as T2D, NAFLD, and CVD.Future Directions: Valuable data from preclinical and clinical investigations have emphasized the SPM functions and influence on oxidative stress- and inflammation-related MetS. Despite these promising findings obtained without compromising host defense, additional efforts are needed to evaluate their potential therapeutic applications and further develop practical tools to monitor their bioavailability to cope with cardiometabolic disorders. Antioxid. Redox Signal. 37, 54-83.
C1 [Dube, Laurent; Spahis, Schohraya; Ould-Chikh, Nour-El-Houda; Marcil, Valerie; Delvin, Edgard; Levy, Emile] Univ Montreal, St Justine Hosp, Res Ctr, Montreal, PQ, Canada.
   [Dube, Laurent; Spahis, Schohraya; Lachaine, Karelle; Lemieux, Andreanne; Monhem, Hanine; Poulin, Sarah-Maude; Randoll, Carolane; Travaillaud, Eva; Marcil, Valerie; Levy, Emile] Univ Montreal, Dept Nutr, Montreal, PQ, Canada.
   [Spahis, Schohraya; Marcil, Valerie; Levy, Emile] Laval Univ, Inst Nutr & Funct Foods, Quebec City, PQ, Canada.
   [Delvin, Edgard] Univ Montreal, Dept Biochem, Montreal, PQ, Canada.
   [Levy, Emile] Univ Montreal, Dept Pediat, Gastroenterol & Hepatol Unit, Montreal, PQ, Canada.
   [Levy, Emile] Univ Montreal, St Justine Hosp, Res Ctr, 3175 Ste Catherine Rd,4-17-005, Montreal, PQ H3T 1C5, Canada.
C3 Universite de Montreal; Centre Hospitalier Universitaire Sainte-Justine;
   Universite de Montreal; Laval University; Universite de Montreal;
   Universite de Montreal; Universite de Montreal; Centre Hospitalier
   Universitaire Sainte-Justine
RP Levy, E (corresponding author), Univ Montreal, St Justine Hosp, Res Ctr, 3175 Ste Catherine Rd,4-17-005, Montreal, PQ H3T 1C5, Canada.
EM emile.levy.hsj@ssss.gouv.qc.ca
OI Spahis, Schohraya/0000-0003-4130-4994
FU J. A. DeSe`ve Research Chair in Nutrition
FX This study was supported by the J. A. DeSe`ve Research Chair in
   Nutrition.
CR Abete I, 2011, NUTR METAB CARDIOVAS, V21, pB1, DOI 10.1016/j.numecd.2011.05.001
   Allahverdian S, 2018, CARDIOVASC RES, V114, P540, DOI 10.1093/cvr/cvy022
   Amos D, 2019, BBA-MOL CELL BIOL L, V1864, P466, DOI 10.1016/j.bbalip.2019.01.002
   Arita M, 2005, J EXP MED, V201, P713, DOI 10.1084/jem.20042031
   Arita M, 2007, J IMMUNOL, V178, P3912, DOI 10.4049/jimmunol.178.6.3912
   Arnardottir HH, 2016, J IMMUNOL, V197, P2362, DOI 10.4049/jimmunol.1502268
   Aursnes M, 2014, J NAT PROD, V77, P910, DOI 10.1021/np4009865
   Bang S, 2012, BRIT J PHARMACOL, V165, P683, DOI 10.1111/j.1476-5381.2011.01568.x
   Bang S, 2010, BRIT J PHARMACOL, V161, P707, DOI 10.1111/j.1476-5381.2010.00909.x
   Bang SS, 2018, J CLIN INVEST, V128, P3568, DOI 10.1172/JCI99888
   Bannenberg G, 2004, BRIT J PHARMACOL, V143, P43, DOI 10.1038/sj.bjp.0705912
   Bannenberg G, 2010, BBA-MOL CELL BIOL L, V1801, P1260, DOI 10.1016/j.bbalip.2010.08.002
   Barbosa-Sicard E, 2005, BIOCHEM BIOPH RES CO, V329, P1275, DOI 10.1016/j.bbrc.2005.02.103
   Barden A, 2018, PROSTAG LEUKOTR ESS, V133, P29, DOI 10.1016/j.plefa.2018.04.004
   Bashir S, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0223070
   Basil MC, 2016, NAT REV IMMUNOL, V16, P51, DOI 10.1038/nri.2015.4
   Bendor CD, 2020, CARDIOVASC DIABETOL, V19, DOI 10.1186/s12933-020-01052-1
   Bento AF, 2011, J IMMUNOL, V187, P1957, DOI 10.4049/jimmunol.1101305
   Blaszczak AM, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/8124563
   Bloch-Damti A, 2005, ANTIOXID REDOX SIGN, V7, P1553, DOI 10.1089/ars.2005.7.1553
   Börgeson E, 2013, CURR OPIN PHARMACOL, V13, P618, DOI 10.1016/j.coph.2013.05.011
   BOGARDUS C, 1984, J CLIN INVEST, V74, P1238, DOI 10.1172/JCI111533
   Brennan EP, 2018, DIABETES, V67, P2657, DOI 10.2337/db17-1317
   Caesar R, 2015, CELL METAB, V22, P658, DOI 10.1016/j.cmet.2015.07.026
   Campbell EL, 2010, P NATL ACAD SCI USA, V107, P14298, DOI 10.1073/pnas.0914730107
   Campo GM, 2004, LIFE SCI, V74, P1289, DOI 10.1016/j.lfs.2003.08.010
   Cao LJ, 2021, EXP THER MED, V22, DOI 10.3892/etm.2021.10656
   Carracedo M, 2019, SEMIN IMMUNOPATHOL, V41, P757, DOI 10.1007/s00281-019-00767-y
   Carracedo M, 2019, CARDIOVASC RES, V115, P1557, DOI 10.1093/cvr/cvy316
   Cawood AL, 2010, ATHEROSCLEROSIS, V212, P252, DOI 10.1016/j.atherosclerosis.2010.05.022
   Cefalu WT, 2019, DIABETES CARE, V42, pS46, DOI 10.2337/dc19-S005
   Cezar TLC, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-39584-6
   Chalasani N, 2012, GASTROENTEROLOGY, V142, P1592, DOI 10.1053/j.gastro.2012.04.001
   Chawla A, 2011, NAT REV IMMUNOL, V11, P738, DOI 10.1038/nri3071
   Chen P, 2009, FEBS LETT, V583, P3478, DOI 10.1016/j.febslet.2009.10.004
   Chiang N, 2000, J EXP MED, V191, P1197, DOI 10.1084/jem.191.7.1197
   Chiang N, 2005, PROSTAG LEUKOTR ESS, V73, P163, DOI 10.1016/j.plefa.2005.05.003
   Chiang N, 2006, METH MOL B, V341, P227
   Chiang N, 2020, ESSAYS BIOCHEM, V64, P443, DOI 10.1042/EBC20200018
   Chiang N, 2019, J CLIN INVEST, V129, P5294, DOI 10.1172/JCI129448
   Chiang N, 2015, J EXP MED, V212, P1203, DOI 10.1084/jem.20150225
   Chiang N, 2012, NATURE, V484, P524, DOI 10.1038/nature11042
   Chiurchiù V, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.00038
   Cho J, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18041892
   CLARIA J, 1995, P NATL ACAD SCI USA, V92, P9475, DOI 10.1073/pnas.92.21.9475
   Clària J, 2012, J IMMUNOL, V189, P2597, DOI 10.4049/jimmunol.1201272
   Colas RA, 2018, CIRC RES, V122, P855, DOI 10.1161/CIRCRESAHA.117.312472
   Colas RA, 2016, J IMMUNOL, V197, P4444, DOI 10.4049/jimmunol.1600837
   Colin S, 2014, IMMUNOL REV, V262, P153, DOI 10.1111/imr.12218
   Crouch MJ, 2019, J LEUKOCYTE BIOL, V106, P241, DOI 10.1002/JLB.3HI1017-405RR
   Dalli J, 2016, P NATL ACAD SCI USA, V113, P12232, DOI 10.1073/pnas.1607003113
   Dalli J, 2015, FASEB J, V29, P2120, DOI 10.1096/fj.14-268441
   Dalli J, 2013, FASEB J, V27, P2573, DOI 10.1096/fj.13-227728
   Dalli J, 2013, SCI REP-UK, V3, DOI 10.1038/srep01940
   Dalli J, 2012, BLOOD, V120, pE60, DOI 10.1182/blood-2012-04-423525
   de la Rosa X, 2018, AM J PATHOL, V188, P950, DOI 10.1016/j.ajpath.2018.01.004
   Deng B, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0102362
   Döcke S, 2013, EUR J ENDOCRINOL, V169, P547, DOI 10.1530/EJE-13-0112
   Dossi CG, 2018, FOOD FUNCT, V9, P4847, DOI [10.1039/C8FO00969D, 10.1039/c8fo00969d]
   Drechsler M, 2015, CIRC RES, V116, P827, DOI 10.1161/CIRCRESAHA.116.305825
   Drouin G, 2019, BIOCHIMIE, V159, P36, DOI 10.1016/j.biochi.2019.01.022
   Ebert T, 2021, ANTIOXID REDOX SIGN, V35, P1426, DOI 10.1089/ars.2020.8184
   Echeverría F, 2019, J NUTR BIOCHEM, V63, P35, DOI 10.1016/j.jnutbio.2018.09.012
   Eckel RH, 2010, LANCET, V375, P181, DOI 10.1016/S0140-6736(09)61794-3
   Engin A, 2017, ADV EXP MED BIOL, V960, P1, DOI 10.1007/978-3-319-48382-5_1
   Estaki M, 2014, WORLD J GASTROENTERO, V20, P15650, DOI 10.3748/wjg.v20.i42.15650
   Fawley J, 2016, J SURG RES, V202, P225, DOI 10.1016/j.jss.2015.12.008
   Flak MB, 2020, J CLIN INVEST, V130, P359, DOI 10.1172/JCI131609
   Flemming JA, 2021, HEPATOLOGY, V74, P3330, DOI 10.1002/hep.32032
   Fredman G, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms12859
   González-Périz A, 2009, FASEB J, V23, P1946, DOI 10.1096/fj.08-125674
   Grenon SM, 2015, J AM HEART ASSOC, V4, DOI 10.1161/JAHA.115.002034
   Grevengoed TJ, 2021, J CLIN INVEST, V131, DOI 10.1172/JCI143861
   Gronert K, 1998, J EXP MED, V187, P1285, DOI 10.1084/jem.187.8.1285
   Han YH, 2019, J CLIN INVEST, V129, P1684, DOI 10.1172/JCI124219
   Harrison SA, 2007, GUT, V56, P1760, DOI 10.1136/gut.2006.112094
   Hasturk H, 2015, ARTERIOSCL THROM VAS, V35, P1123, DOI 10.1161/ATVBAHA.115.305324
   Hellmann J, 2011, FASEB J, V25, P2399, DOI 10.1096/fj.10-178657
   Heshmati J, 2019, PHARMACOL RES, V149, DOI 10.1016/j.phrs.2019.104462
   Hiram R, 2015, AM J PHYSIOL-LUNG C, V309, pL776, DOI 10.1152/ajplung.00177.2015
   Hiram R, 2014, AM J PHYSIOL-HEART C, V307, pH1547, DOI 10.1152/ajpheart.00452.2014
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Horrillo R, 2010, J IMMUNOL, V184, P3978, DOI 10.4049/jimmunol.0901355
   Hu XO, 2019, LIFE SCI, V218, P38, DOI 10.1016/j.lfs.2018.12.028
   Irish A, 2009, BMC NEPHROL, V10, DOI 10.1186/1471-2369-10-1
   Ishida T, 2010, INFLAMM BOWEL DIS, V16, P87, DOI 10.1002/ibd.21029
   Isobe Y, 2012, J BIOL CHEM, V287, P10525, DOI 10.1074/jbc.M112.340612
   Itoh M, 2007, ARTERIOSCL THROM VAS, V27, P1918, DOI 10.1161/ATVBAHA.106.136853
   Jang H, 2020, CLIN NUTR, V39, P765, DOI 10.1016/j.clnu.2019.03.032
   Grilli DJ, 2019, ANAEROBE, V56, P1, DOI 10.1016/j.anaerobe.2019.01.001
   Joffre J, 2021, ANTIOXID REDOX SIGN, V35, P1291, DOI 10.1089/ars.2021.0027
   Jouvene CC, 2019, FASEB J, V33, P13794, DOI 10.1096/fj.201902003R
   Jung TW, 2017, CELL SIGNAL, V34, P133, DOI 10.1016/j.cellsig.2017.03.013
   Kang ES, 2011, FREE RADICAL BIO MED, V50, P680, DOI 10.1016/j.freeradbiomed.2010.12.021
   Kang JX, 2004, NATURE, V427, P504, DOI 10.1038/427504a
   Kang YE, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0154003
   Kim YS, 2016, EUR J NUTR, V55, P1707, DOI 10.1007/s00394-015-0989-8
   Kosaraju R, 2017, J IMMUNOL, V198, P4738, DOI 10.4049/jimmunol.1601031
   Kozyra M, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-32722-6
   Krishnamoorthy S, 2012, AM J PATHOL, V180, P2018, DOI 10.1016/j.ajpath.2012.01.028
   Krishnamoorthy S, 2010, P NATL ACAD SCI USA, V107, P1660, DOI 10.1073/pnas.0907342107
   Kure I, 2010, J PHARMACOL EXP THER, V332, P541, DOI 10.1124/jpet.109.159046
   Kuzumoto T, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0250862
   Laguna-Fernandez A, 2018, CIRCULATION, V138, P1693, DOI 10.1161/CIRCULATIONAHA.117.032801
   Lai YHL, 2013, CLIN NUTR, V32, P966, DOI 10.1016/j.clnu.2013.05.002
   Laiglesia LM, 2018, INT J OBESITY, V42, P572, DOI 10.1038/ijo.2017.226
   Lee CO, 2021, ANN MED, V53, P1065, DOI 10.1080/07853890.2021.1943514
   Lee SE, 2015, J CARDIOVASC PHARM, V66, P108, DOI 10.1097/FJC.0000000000000251
   Lee Y, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0183028
   León IC, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8081156
   Leoni G, 2015, MUCOSAL IMMUNOL, V8, P959, DOI 10.1038/mi.2015.63
   Leung KS, 2021, FREE RADICAL BIO MED, V162, DOI 10.1016/j.freeradbiomed.2020.11.025
   Levental KR, 2016, BIOPHYS J, V110, P1800, DOI 10.1016/j.bpj.2016.03.012
   Levy BD, 2001, NAT IMMUNOL, V2, P612, DOI 10.1038/89759
   Li RD, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/9203716
   Loomba R, 2013, NAT REV GASTRO HEPAT, V10, P686, DOI 10.1038/nrgastro.2013.171
   Lopategi A, 2019, J LEUKOCYTE BIOL, V105, P25, DOI 10.1002/JLB.3HI0517-206RR
   López-Vicario C, 2019, FASEB J, V33, P7072, DOI 10.1096/fj.201802587R
   Lorente-Cebrián S, 2013, J PHYSIOL BIOCHEM, V69, P633, DOI 10.1007/s13105-013-0265-4
   Lv CJ, 2019, MED SCI MONITOR, V25, P8181, DOI 10.12659/MSM.917380
   Malo MS, 2015, EBIOMEDICINE, V2, P2016, DOI 10.1016/j.ebiom.2015.11.027
   Marcon R, 2013, J IMMUNOL, V191, P4288, DOI 10.4049/jimmunol.1202743
   Marcos-Delgado A, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18030887
   Martínez-Fernández L, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201900358
   Martínez-Fernández L, 2017, FASEB J, V31, P2135, DOI 10.1096/fj.201600859R
   Masterton GS, 2010, ALIMENT PHARM THER, V31, P679, DOI 10.1111/j.1365-2036.2010.04230.x
   Miao ZJ, 2021, BIOMED RES INT, V2021, DOI 10.1155/2021/6657646
   Mirmiran P, 2012, NUTRITION, V28, P856, DOI 10.1016/j.nut.2011.11.031
   MOI P, 1994, P NATL ACAD SCI USA, V91, P9926, DOI 10.1073/pnas.91.21.9926
   Morgan A, 2021, EUR J HEALTH ECON, V22, P505, DOI 10.1007/s10198-020-01256-y
   Morgan MJ, 2007, ANTIOXID REDOX SIGN, V9, P1471, DOI 10.1089/ars.2007.1658
   Mori TA, 2003, FREE RADICAL BIO MED, V35, P772, DOI 10.1016/S0891-5849(03)00407-6
   Mori TA, 2000, REDOX REP, V5, P45, DOI 10.1179/rer.2000.5.1.45
   Morin C, 2015, AM J PHYSIOL-HEART C, V309, pH93, DOI 10.1152/ajpheart.00823.2014
   Morin C, 2012, AM J HYPERTENS, V25, P756, DOI 10.1038/ajh.2012.45
   MORRIS MC, 1993, CIRCULATION, V88, P523, DOI 10.1161/01.CIR.88.2.523
   Nenseter MS, 1996, CURR OPIN LIPIDOL, V7, P8, DOI 10.1097/00041433-199602000-00003
   Neuenschwander M, 2020, PLOS MED, V17, DOI 10.1371/journal.pmed.1003347
   Neuhofer A, 2013, DIABETES, V62, P1945, DOI 10.2337/db12-0828
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Oh DY, 2010, CELL, V142, P687, DOI 10.1016/j.cell.2010.07.041
   Oh SF, 2012, J IMMUNOL, V188, P4527, DOI 10.4049/jimmunol.1103652
   Oh SF, 2011, J CLIN INVEST, V121, P569, DOI 10.1172/JCI42545
   Pal A, 2020, FASEB J, V34, P10640, DOI 10.1096/fj.202000830R
   Palmer CD, 2011, J LEUKOCYTE BIOL, V90, P459, DOI 10.1189/jlb.0311145
   Pamplona FA, 2012, P NATL ACAD SCI USA, V109, P21134, DOI 10.1073/pnas.1202906109
   Park CK, 2011, J NEUROSCI, V31, P18433, DOI 10.1523/JNEUROSCI.4192-11.2011
   Park CK, 2011, J NEUROSCI, V31, P15072, DOI 10.1523/JNEUROSCI.2443-11.2011
   Park J, 2020, ACS PHARMACOL TRANSL, V3, P88, DOI 10.1021/acsptsci.9b00075
   Paulweber B, 2010, HORM METAB RES, V42, pS3, DOI 10.1055/s-0029-1240928
   Perreault M, 2001, NAT MED, V7, P1138, DOI 10.1038/nm1001-1138
   Petri MH, 2017, BRIT J PHARMACOL, V174, P4043, DOI 10.1111/bph.13707
   Petri MH, 2015, INT J CARDIOL, V179, P370, DOI 10.1016/j.ijcard.2014.11.010
   Pillai S., 2005, International Journal of Cosmetic Science, V27, P17, DOI 10.1111/j.1467-2494.2004.00241.x
   Pohl R, 2015, EXP MOL PATHOL, V98, P295, DOI 10.1016/j.yexmp.2015.02.005
   Qiu WH, 2014, EXP THER MED, V7, P1481, DOI 10.3892/etm.2014.1641
   Quiros M, 2019, TRENDS MOL MED, V25, P124, DOI 10.1016/j.molmed.2018.12.004
   Rajamäki K, 2016, ARTERIOSCL THROM VAS, V36, P1937, DOI 10.1161/ATVBAHA.115.307312
   Ramirez JL, 2019, J SURG RES, V238, P164, DOI 10.1016/j.jss.2019.01.038
   RIEHL TE, 1994, AM J PHYSIOL-GASTR L, V267, pG687, DOI 10.1152/ajpgi.1994.267.4.G687
   Rius B, 2017, FASEB J, V31, P5384, DOI 10.1096/fj.201700394R
   Rius B, 2014, FASEB J, V28, P836, DOI 10.1096/fj.13-235614
   Rius B, 2012, FRONT IMMUNOL, V3, DOI 10.3389/fimmu.2012.00257
   Salic K, 2016, ATHEROSCLEROSIS, V250, P158, DOI 10.1016/j.atherosclerosis.2016.05.001
   Samuel VT, 2012, CELL, V148, P852, DOI 10.1016/j.cell.2012.02.017
   Sato A, 2010, DIABETES, V59, P2495, DOI 10.2337/db09-1554
   Sato M, 2019, FASEB J, V33, P12750, DOI 10.1096/fj.201900283R
   Saw CLL, 2013, FOOD CHEM TOXICOL, V62, P869, DOI 10.1016/j.fct.2013.10.023
   Schaller MS, 2020, J AM HEART ASSOC, V9, DOI 10.1161/JAHA.120.016113
   Schaller MS, 2017, J CLIN LIPIDOL, V11, P1289, DOI 10.1016/j.jacl.2017.06.011
   Schulte F, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-75353-6
   Scuteri A, 2015, EUR J PREV CARDIOL, V22, P486, DOI 10.1177/2047487314525529
   Serhan CN, 2018, J IMMUNOL, V201, P3161, DOI 10.4049/jimmunol.1800806
   Serhan CN, 2018, J CLIN INVEST, V128, P2657, DOI 10.1172/JCI97943
   Serhan CN, 2014, NATURE, V510, P92, DOI 10.1038/nature13479
   Serhan CN, 2012, FASEB J, V26, P1755, DOI 10.1096/fj.11-201442
   Serhan CN, 2011, CHEM REV, V111, P5922, DOI 10.1021/cr100396c
   Serhan CN, 2009, J EXP MED, V206, P15, DOI 10.1084/jem.20081880
   Serhan CN, 2006, J IMMUNOL, V176, P1848, DOI 10.4049/jimmunol.176.3.1848
   Serhan CN, 2005, PROSTAG LEUKOTR ESS, V73, P141, DOI 10.1016/j.plefa.2005.05.002
   Serhan CN, 2002, J EXP MED, V196, P1025, DOI 10.1084/jem.20020760
   Serhan CN, 2000, J EXP MED, V192, P1197, DOI 10.1084/jem.192.8.1197
   Silverman ES, 1999, P ASSOC AM PHYSICIAN, V111, P525, DOI 10.1046/j.1525-1381.1999.t01-1-99231.x
   Sima C, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-13185-7
   Simopoulos AP, 2021, MOL ASPECTS MED, V77, DOI 10.1016/j.mam.2021.100943
   Skarke C, 2015, J LIPID RES, V56, P1808, DOI 10.1194/jlr.M060392
   Spahis S, 2017, ANTIOXID REDOX SIGN, V26, P445, DOI 10.1089/ars.2016.6756
   Spahis S, 2017, ANTIOXID REDOX SIGN, V26, P519, DOI 10.1089/ars.2016.6776
   Spite M, 2009, BRIT J PHARMACOL, V158, P1062, DOI 10.1111/j.1476-5381.2009.00234.x
   Spite M, 2009, NATURE, V461, P1287, DOI 10.1038/nature08541
   Steyn NP, 2004, PUBLIC HEALTH NUTR, V7, P147, DOI 10.1079/PHN2003586
   Sulciner ML, 2018, J EXP MED, V215, P115, DOI 10.1084/jem.20170681
   Sun QC, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/9634803
   Sun ZP, 2019, INT IMMUNOPHARMACOL, V75, DOI 10.1016/j.intimp.2019.105825
   Tamargo JA, 2021, AM J CLIN NUTR, V113, P593, DOI 10.1093/ajcn/nqaa362
   Tang YN, 2013, DIABETES, V62, P618, DOI 10.2337/db12-0684
   Teague H, 2013, J LIPID RES, V54, P3130, DOI 10.1194/jlr.M042457
   Titos E, 2016, J IMMUNOL, V197, P3360, DOI 10.4049/jimmunol.1502522
   Tungen JE, 2020, J NAT PROD, V83, P2255, DOI 10.1021/acs.jnatprod.0c00385
   Tungen JE, 2014, CHEM-EUR J, V20, P14575, DOI 10.1002/chem.201404721
   Vemuri Madhuri, 2007, Metabolic Syndrome and Related Disorders, V5, P315, DOI 10.1089/met.2007.0007
   Viola JR, 2016, CIRC RES, V119, P1030, DOI 10.1161/CIRCRESAHA.116.309492
   Wang HG, 2016, AM J TRANSL RES, V8, P2758
   Wanninger J, 2012, MOL CELL ENDOCRINOL, V349, P248, DOI 10.1016/j.mce.2011.10.032
   Warner DR, 2019, J LIPID RES, V60, P2034, DOI 10.1194/jlr.RA119000200
   White PJ, 2010, DIABETES, V59, P3066, DOI 10.2337/db10-0054
   Yanai Hidekatsu, 2018, J Clin Med Res, V10, P281, DOI 10.14740/jocmr3362w
   Yang ML, 2020, OCUL SURF, V18, P470, DOI 10.1016/j.jtos.2020.04.011
   Yary T, 2017, J HUM NUTR DIET, V30, P506, DOI 10.1111/jhn.12437
   Zgorzynska E, 2017, PHARMACOL REP, V69, P935, DOI 10.1016/j.pharep.2017.04.009
   Zhang F, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0113107
   Zhang G, 2012, J CLIN ENDOCR METAB, V97, pE973, DOI 10.1210/jc.2011-2997
   Zhao QF, 2016, J TRANSL MED, V14, DOI 10.1186/s12967-016-0835-7
NR 214
TC 7
Z9 7
U1 3
U2 11
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD JUL 1
PY 2022
VL 37
IS 1-3
BP 54
EP 83
DI 10.1089/ars.2021.0156
PG 30
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 2U1SW
UT WOS:000822943600004
PM 35072542
DA 2025-06-11
ER

PT J
AU Cahova, M
   Chrastina, P
   Hansikova, H
   Drahota, Z
   Trnovska, J
   Skop, V
   Spacilova, J
   Malinska, H
   Oliyarnyk, O
   Papackova, Z
   Palenickova, E
   Kazdova, L
AF Cahova, Monika
   Chrastina, Petr
   Hansikova, Hana
   Drahota, Zdenek
   Trnovska, Jaroslava
   Skop, Vojtech
   Spacilova, Jana
   Malinska, Hana
   Oliyarnyk, Olena
   Papackova, Zuzana
   Palenickova, Eliska
   Kazdova, Ludmila
TI Carnitine supplementation alleviates lipid metabolism derangements and
   protects against oxidative stress in non-obese hereditary
   hypertriglyceridemic rats
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE metabolic syndrome; insulin resistance; antioxidant; liver steatosis;
   mass spectrometry
ID INSULIN SENSITIVITY; ANTIOXIDANT; RESISTANCE; PRODUCTS; PROFILE; WEIGHT
AB The aim of this study was to estimate the effect of carnitine supplementation on lipid disorders and peripheral tissue insulin sensitivity in a non-obese animal model of insulin resistance, the hereditary hypertriglyceridemic (HHTg) rat. Male HHTg rats were fed a standard diet, and half of them received daily doses of carnitine (500 mg.kg(-1) body weight) for 8 weeks. Rats of the original Wistar strain were used for comparison. HHTg rats exhibited increased urinary excretion of free carnitine and reduced carnitine content in the liver and blood. Carnitine supplementation compensated for this shortage and promoted urinary excretion of acetylcarnitine without any signs of (acyl) carnitine accumulation in skeletal muscle. Compared with their untreated littermates, carnitine-treated HHTg rats exhibited lower weight gain, reduced liver steatosis, lower fasting triglyceridemia, and greater reduction of serum free fatty acid content after glucose load. Carnitine treatment was associated with increased mitochondrial biogenesis and oxidative capacity for fatty acids, amelioration of oxidative stress, and restored substrate switching in the liver. In skeletal muscle (diaphragm), carnitine supplementation was associated with significantly higher palmitate oxidation and a more favorable complete to incomplete oxidation products ratio. Carnitine supplementation further enhanced insulin sensitivity ex vivo. No effects on whole-body glucose tolerance were observed. Our data suggest that some metabolic syndrome-related disorders, particularly fatty acid oxidation, steatosis, and oxidative stress in the liver, could be attenuated by carnitine supplementation. The effect of carnitine could be explained, at least partly, by enhanced substrate oxidation and increased fatty acid transport from tissues in the form of short-chain acylcarnitines.
C1 [Cahova, Monika; Trnovska, Jaroslava; Skop, Vojtech; Malinska, Hana; Oliyarnyk, Olena; Papackova, Zuzana; Palenickova, Eliska; Kazdova, Ludmila] Inst Clin & Expt Med, Ctr Med Expt, Videnska 1958-9, Prague 4, Czech Republic.
   [Chrastina, Petr] Charles Univ Prague, Fac Med 1, Inst Inherited Metab Disorders, Prague 2, Czech Republic.
   [Chrastina, Petr; Hansikova, Hana; Trnovska, Jaroslava] Gen Univ Hosp Prague, Prague 2, Czech Republic.
   [Hansikova, Hana; Spacilova, Jana] Charles Univ Prague, Fac Med 1, Dept Pediat & Adolescent Med, Prague, Czech Republic.
   [Drahota, Zdenek] Acad Sci Czech Republ, Inst Physiol, Prague 4, Czech Republic.
   [Skop, Vojtech] Inst Chem Technol, Dept Biochem & Microbiol, CR-16628 Prague, Czech Republic.
   [Palenickova, Eliska] Charles Univ Prague, Fac Sci, Dept Cell Biol, Prague 2, Czech Republic.
C3 Institute for Clinical & Experimental Medicine (IKEM); Charles
   University Prague; General University Hospital Prague; Charles
   University Prague; Czech Academy of Sciences; Institute of Physiology of
   the Czech Academy of Sciences; University of Chemistry & Technology,
   Prague; Charles University Prague
RP Cahova, M (corresponding author), Inst Clin & Expt Med, Ctr Med Expt, Videnska 1958-9, Prague 4, Czech Republic.
EM monika.cahova@ikem.cz
RI Oliyarnyk, Olena/Q-6380-2019; Cahova, Monika/Z-1568-2018; Drahota,
   Zdenek/F-8296-2014; Krizova, Jana/E-8721-2017; Chrastina,
   Petr/K-8981-2017; Hansikova, Hana/E-9350-2017; Skop,
   Vojtech/LBI-2231-2024
OI Drahota, Zdenek/0000-0003-2117-6809; Cahova, Monika/0000-0003-2640-5084;
   Trnovska, Jaroslava/0000-0001-6468-8244; Krizova,
   Jana/0000-0003-1841-7341; Chrastina, Petr/0000-0003-4404-6513;
   Hansikova, Hana/0000-0002-2734-225X; Skop, Vojtech/0000-0002-4685-4429;
   Oliyarnyk, Olena/0000-0002-4912-6187
FU MH CR-DRO ("Institute for Clinical and Experimental Medicine - IKEM) [IN
   00023001]; MH CZ-DRO VFN [64165]; ERC CZ program [LL 1204]; Grant Agency
   of the Czech Republic [14-36804G]
FX This study was supported by MH CR-DRO ("Institute for Clinical and
   Experimental Medicine - IKEM, IN 00023001"), MH CZ-DRO VFN 64165, grant
   No. LL 1204 (within the ERC CZ program), and project 14-36804G from the
   Grant Agency of the Czech Republic.
CR Aebi H, 1974, METHODS ENZYM ANAL, V2nd, P673, DOI [10.1016/B978-0-12-091302-2.50032-3, DOI 10.1016/B978-0-12-091302-2.50032-3]
   Augustyniak A, 2009, ALCOHOL, V43, P217, DOI 10.1016/j.alcohol.2008.12.005
   Bianchi PB, 1996, J NUTR, V126, P2873
   Bloomer RJ, 2009, NUTR METAB, V6, DOI 10.1186/1743-7075-6-25
   Cahova M, 2004, EXP CLIN ENDOCR DIAB, V112, P549, DOI 10.1055/s-2004-830398
   Cao Y, 2011, TOHOKU J EXP MED, V224, P209, DOI 10.1620/tjem.224.209
   Derin N, 2004, J PHYSIOL PHARMACOL, V55, P595
   Derosa G, 2003, CLIN THER, V25, P1429, DOI 10.1016/S0149-2918(03)80130-3
   Derosa G, 2010, ENDOCR J, V57, P777, DOI 10.1507/endocrj.K10E-049
   Derosa G, 2010, INTERNAL MED, V49, P1717, DOI 10.2169/internalmedicine.49.3401
   Drahota Z, 2014, PHYSIOL RES, V63, P1, DOI 10.33549/physiolres.932600
   Dudkova Z, 1995, KLIN BIOCH METAB, V3, P178
   Galloway SDR, 2011, AMINO ACIDS, V41, P507, DOI 10.1007/s00726-010-0770-5
   Gomez-Amores L, 2007, J NUTR BIOCHEM, V18, P533, DOI 10.1016/j.jnutbio.2006.10.004
   González-Ortiz M, 2008, ANN NUTR METAB, V52, P335, DOI 10.1159/000151488
   Gülçin I, 2006, LIFE SCI, V78, P803, DOI 10.1016/j.lfs.2005.05.103
   Kang JS, 2011, PHYTOTHER RES, V25, P1789, DOI 10.1002/ptr.3476
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   KAWAMURA N, 1981, J NEUROCHEM, V36, P1786, DOI 10.1111/j.1471-4159.1981.tb00432.x
   Koves TR, 2008, CELL METAB, V7, P45, DOI 10.1016/j.cmet.2007.10.013
   Koves TR, 2005, J BIOL CHEM, V280, P33588, DOI 10.1074/jbc.M507621200
   Liang Y, 1998, Asia Pac J Clin Nutr, V7, P192
   Marcovina SM, 2013, TRANSL RES, V161, P73, DOI 10.1016/j.trsl.2012.10.006
   Mingorance C, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034268
   Mingorance C, 2009, BRIT J NUTR, V102, P1145, DOI 10.1017/S0007114509389230
   Molfino A, 2010, JPEN-PARENTER ENTER, V34, P295, DOI 10.1177/0148607109353440
   Muoio DM, 2012, CELL METAB, V15, P764, DOI 10.1016/j.cmet.2012.04.005
   Noland RC, 2009, J BIOL CHEM, V284, P22840, DOI 10.1074/jbc.M109.032888
   Power RA, 2007, DIABETOLOGIA, V50, P824, DOI 10.1007/s00125-007-0605-4
   Rahbar AR, 2005, EUR J CLIN NUTR, V59, P592, DOI 10.1038/sj.ejcn.1602109
   Rajasekar P., 2006, DIABETOL CROAT, V34, P87
   Ringseis R, 2012, EUR J NUTR, V51, P1, DOI 10.1007/s00394-011-0284-2
   SACHAN DS, 1984, AM J CLIN NUTR, V39, P738, DOI 10.1093/ajcn/39.5.738
   Skop V, 2012, PHYSIOL RES, V61, P287, DOI 10.33549/physiolres.932285
   Vidal-Casariego A, 2013, EXP CLIN ENDOCR DIAB, V121, P234, DOI 10.1055/s-0033-1333688
   Voulgari C, 2011, J AM COLL CARDIOL, V58, P1343, DOI 10.1016/j.jacc.2011.04.047
   VRANA A, 1993, ANN NY ACAD SCI, V683, P57, DOI 10.1111/j.1749-6632.1993.tb35692.x
   VRANA A, 1990, TRANSPLANT P, V22, P2579
   WARD PA, 1985, J CLIN INVEST, V76, P517, DOI 10.1172/JCI112001
   Yapar K, 2007, EXP TOXICOL PATHOL, V59, P121, DOI 10.1016/j.etp.2007.02.009
NR 40
TC 16
Z9 19
U1 1
U2 23
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD MAR
PY 2015
VL 40
IS 3
BP 280
EP 291
DI 10.1139/apnm-2014-0163
PG 12
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA CE6LX
UT WOS:000351949000011
PM 25723909
DA 2025-06-11
ER

PT J
AU Sun, J
   Jin, XL
   Li, YL
AF Sun, Jing
   Jin, Xiuli
   Li, Yiling
TI Current strategies for nonalcoholic fatty liver disease treatment
   (Review)
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Review
DE NAFLD; NASH; insulin resistance; oxidative stress; inflammation; lipid
   accumulation
ID ENDOPLASMIC-RETICULUM STRESS; HEPATIC LIPID-ACCUMULATION; VITAMIN-D;
   METABOLIC SYNDROME; DOUBLE-BLIND; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   GUT MICROBIOTA; UP-REGULATION; SYNBIOTIC SUPPLEMENTATION
AB Nonalcoholic fatty liver disease (NAFLD), the most common chronic hepatic disease, has become a leading health problem worldwide. The present review summarized the methods and mechanisms to treat NAFLD, including the Mediterranean diet, physical activity and exercise, bariatric surgery and specific therapeutic agents, including statins, peroxisome proliferator-activated receptor agonists, cenicriviroc and farnesoid X receptor agonists. Biologically active substances, such as peptides, alkaloids, polyphenolic compounds, silymarin, antibiotics, fatty acids, vitamins, probiotics, synbiotics and lamiaceae have also demonstrated actions that combat NAFLD. Considering their different mechanisms of action, combining some of them may prove an efficacious treatment for NAFLD. In this light, the present review describes recent progress and future prospects in treating NAFLD.
C1 [Sun, Jing; Jin, Xiuli; Li, Yiling] China Med Univ, Dept Gastroenterol, Hosp 1, 155 Nanjing North St, Shenyang 110002, Liaoning, Peoples R China.
C3 China Medical University
RP Li, YL (corresponding author), China Med Univ, Dept Gastroenterol, Hosp 1, 155 Nanjing North St, Shenyang 110002, Liaoning, Peoples R China.
EM lyl-72@163.com
RI Li, Yiling/HGF-0094-2022
FU General Program of Educational Department of Liaoning Province
FX Not applicable.
CR Abdel-Razik A, 2018, EUR J GASTROEN HEPAT, V30, P1237, DOI 10.1097/MEG.0000000000001232
   Abenavoli L, 2018, PHARMACEUTICALS-BASE, V11, DOI 10.3390/ph11040104
   Abenavoli L, 2018, PHYTOTHER RES, V32, P2202, DOI 10.1002/ptr.6171
   Albracht-Schulte K, 2018, J NUTR BIOCHEM, V58, P1, DOI 10.1016/j.jnutbio.2018.02.012
   Aldoheyan T, 2017, SURG ENDOSC, V31, P1142, DOI 10.1007/s00464-016-5082-8
   Alisi A, 2014, ALIMENT PHARM THER, V39, P1276, DOI 10.1111/apt.12758
   Alonso-Domínguez R, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010162
   Amanullah I, 2019, POSTGRAD MED J, V95, P601, DOI 10.1136/postgradmedj-2018-136364
   Martínez-González MA, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph192013653
   Arai N, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-20296-3
   Armstrong MJ, 2016, LANCET, V387, P679, DOI 10.1016/S0140-6736(15)00803-X
   Asadipooya K, 2019, INT J ENDOCRINOL, V2019, DOI 10.1155/2019/2151302
   Baidal JAW, 2016, SCI TRANSL MED, V8, DOI 10.1126/scitranslmed.aad8390
   Ballestri S, 2016, J GASTROEN HEPATOL, V31, P936, DOI 10.1111/jgh.13264
   Barbosa-da-Silva S, 2015, LIFE SCI, V127, P73, DOI 10.1016/j.lfs.2015.02.003
   Barchetta I, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113302
   Battista F, 2021, OBES REV, V22, DOI 10.1111/obr.13269
   Bea JW, 2015, METABOLISM, V64, P447, DOI 10.1016/j.metabol.2014.11.010
   Romero LBM, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.778740
   Boubia B, 2018, J MED CHEM, V61, P2246, DOI 10.1021/acs.jmedchem.7b01285
   Brandt A, 2017, NUTRIENTS, V9, DOI 10.3390/nu9091013
   Brault M, 2014, METABOLISM, V63, P735, DOI 10.1016/j.metabol.2014.02.014
   Brunner KT, 2019, CURR OBES REP, V8, P220, DOI 10.1007/s13679-019-00345-1
   Cabré N, 2019, METABOLISM, V99, P81, DOI 10.1016/j.metabol.2019.07.002
   Cai LY, 2015, FRONT MICROBIOL, V6, DOI 10.3389/fmicb.2015.00981
   Caiazzo R, 2014, ANN SURG, V260, P893, DOI 10.1097/SLA.0000000000000945
   Cassard AM, 2018, CLIN MOL HEPATOL, V24, P100, DOI 10.3350/cmh.2017.0067
   Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI 10.1002/hep.29367
   Chen C, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700483
   Chen L, 2021, FOOD CHEM TOXICOL, V154, DOI 10.1016/j.fct.2021.112314
   Chen Q, 2017, NUTRIENTS, V9, DOI 10.3390/nu9020096
   Chen SH, 2015, DIGEST LIVER DIS, V47, P226, DOI 10.1016/j.dld.2014.11.015
   Cheng C, 2020, EUR J PHARMACOL, V870, DOI 10.1016/j.ejphar.2020.172922
   Chiang WD, 2014, J FUNCT FOODS, V11, P482, DOI 10.1016/j.jff.2014.08.003
   Cho Y, 2022, BMC MED, V20, DOI 10.1186/s12916-022-02288-2
   Choudhary NS, 2019, J CLIN EXP HEPATOL, V9, P731, DOI 10.1016/j.jceh.2019.06.004
   Cui CX, 2017, J ETHNOPHARMACOL, V208, P24, DOI 10.1016/j.jep.2017.06.030
   Cui HX, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/8930374
   Curcio A, 2020, MEDICINA-LITHUANIA, V56, DOI 10.3390/medicina56100544
   Cusi K, 2016, ANN INTERN MED, V165, P305, DOI 10.7326/M15-1774
   Da Silva HE, 2014, J ACAD NUTR DIET, V114, P1181, DOI 10.1016/j.jand.2014.01.009
   Diab F, 2022, MOLECULES, V27, DOI 10.3390/molecules27155043
   Dongiovanni P, 2021, EUR J CLIN INVEST, V51, DOI 10.1111/eci.13519
   Du WW, 2015, MOL THER, V23, P1222, DOI 10.1038/mt.2015.64
   Dumeus S, 2018, CELL PHYSIOL BIOCHEM, V48, P1942, DOI 10.1159/000492518
   EASL, 2016, OBESITY FACTS, V9, P65, DOI [10.1159/000443344, 10.1007/s00125-016-3902-y, 10.1016/j.jhep.2015.11.004]
   Ebrahimpour S, 2020, AGEING RES REV, V62, DOI 10.1016/j.arr.2020.101095
   Reyes-Quiroz ME, 2014, EUR J NUTR, V53, P1707, DOI 10.1007/s00394-014-0677-0
   Eliades M, 2015, WORLD J GASTROENTERO, V21, P1718, DOI 10.3748/wjg.v21.i6.1718
   Eslam M, 2020, J HEPATOL, V73, P202, DOI 10.1016/j.jhep.2020.03.039
   Eslamparast T, 2014, AM J CLIN NUTR, V99, P535, DOI 10.3945/ajcn.113.068890
   Faghihzadeh F, 2015, BRIT J NUTR, V114, P796, DOI 10.1017/S0007114515002433
   Famouri F, 2017, J PEDIATR GASTR NUTR, V64, P413, DOI 10.1097/MPG.0000000000001422
   Fang YY, 2020, FRONT CELL DEV BIOL, V8, DOI 10.3389/fcell.2020.602574
   Farrag SM, 2018, LIFE SCI, V203, P129, DOI 10.1016/j.lfs.2018.04.034
   Feng WH, 2019, DIABETES-METAB RES, V35, DOI 10.1002/dmrr.3138
   Fernández-Martínez E, 2019, J FOOD BIOCHEM, V43, DOI 10.1111/jfbc.12986
   Figueiredo PS, 2018, MOLECULES, V23, DOI 10.3390/molecules23040877
   Fiorucci S, 2020, EXPERT OPIN INV DRUG, V29, P623, DOI 10.1080/13543784.2020.1763302
   Flint A, 2021, ALIMENT PHARM THER, V54, P1150, DOI 10.1111/apt.16608
   Friedman SL, 2018, HEPATOLOGY, V67, P1754, DOI 10.1002/hep.29477
   Fujinaga Y, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21155589
   Gawrieh S, 2021, HEPATOLOGY, V74, P1809, DOI 10.1002/hep.31843
   Giannini EG, 2018, DIGEST DIS SCI, V63, P1946, DOI 10.1007/s10620-018-5052-1
   Glen J, 2016, BMJ-BRIT MED J, V354, DOI 10.1136/bmj.i4428
   Gold-Smith F, 2016, NUTRIENTS, V8, DOI 10.3390/nu8070396
   Gu LY, 2015, HORM METAB RES, V47, P259, DOI 10.1055/s-0034-1384569
   Gu M, 2016, FRONT PHARMACOL, V7, DOI 10.3389/fphar.2016.00345
   Gu XQ, 2019, MOL MED REP, V20, P2450, DOI 10.3892/mmr.2019.10457
   Guo T, 2016, SCI REP-UK, V6, DOI 10.1038/srep22612
   Gutiérrez-Grijalva EP, 2019, FOOD RES INT, V116, P676, DOI 10.1016/j.foodres.2018.08.096
   Hashida R, 2017, J HEPATOL, V66, P142, DOI 10.1016/j.jhep.2016.08.023
   Hassanian M, 2014, SAUDI J GASTROENTERO, V20, P270, DOI 10.4103/1319-3767.141684
   He WX, 2019, DIGEST DIS SCI, V64, P3182, DOI 10.1007/s10620-019-05657-9
   He ZY, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.745609
   Helsley RN, 2020, CURR DIABETES REP, V20, DOI 10.1007/s11892-020-01342-8
   Hernandez ED, 2019, HEPATOL COMMUN, V3, P1085, DOI 10.1002/hep4.1368
   Hinrichs H, 2023, ENDOCRINOLOGY, V164, DOI 10.1210/endocr/bqad010
   Hofmann J, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms221910276
   Hosseini H, 2020, INT J BIOCHEM CELL B, V119, DOI 10.1016/j.biocel.2019.105667
   Hu QC, 2021, PHARMACOL RES, V165, DOI 10.1016/j.phrs.2021.105444
   Husain NE, 2015, EXPERT OPIN DRUG SAF, V14, P1445, DOI 10.1517/14740338.2015.1063613
   Inoue Y, 2018, CURR OBES REP, V7, P276, DOI 10.1007/s13679-018-0317-8
   Jain MR, 2018, LIVER INT, V38, P1084, DOI 10.1111/liv.13634
   Jeyapal S, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-29222-y
   Jian J, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.841132
   Jiang XF, 2020, FRONT MED-LAUSANNE, V7, DOI 10.3389/fmed.2020.00361
   Jin LL, 2021, PEPTIDES, V143, DOI 10.1016/j.peptides.2021.170597
   Sáez-Lara MJ, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17060928
   Karlsson C, 2020, J CLIN ENDOCR METAB, V105, DOI 10.1210/clinem/dgaa558
   Kasper P, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10051247
   Khalesi S, 2018, EUR J NUTR, V57, P2037, DOI 10.1007/s00394-017-1568-y
   Khalil M, 2019, J ETHNOPHARMACOL, V239, DOI 10.1016/j.jep.2019.111919
   Kheong CW, 2017, CLIN GASTROENTEROL H, V15, P1940, DOI 10.1016/j.cgh.2017.04.016
   Klaebel JH, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9090808
   Klaebel JH, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112834
   Koopman KE, 2014, HEPATOLOGY, V60, P545, DOI 10.1002/hep.27149
   Koperska A, 2022, NUTRIENTS, V14, DOI 10.3390/nu14173459
   Korsholm AS, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18030554
   Kostapanos MS, 2014, DRUG SAFETY, V37, P481, DOI 10.1007/s40264-014-0169-4
   Kuchay MS, 2020, DIABETOLOGIA, V63, P2434, DOI 10.1007/s00125-020-05265-7
   Lazarus JV, 2021, JHEP REP, V3, DOI 10.1016/j.jhepr.2021.100234
   Lee JI, 2021, AM J GASTROENTEROL, V116, P116, DOI 10.14309/ajg.0000000000000845
   Lefebvre E, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0158156
   Leong PK, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/6171658
   Li DH, 2017, PHARMACOGN MAG, V13, P677, DOI 10.4103/pm.pm_584_16
   Li GY, 2017, BIOMED PHARMACOTHER, V89, P536, DOI 10.1016/j.biopha.2017.02.024
   Li H, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.843872
   Li P, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.917329
   Liang LP, 2022, INT IMMUNOPHARMACOL, V104, DOI 10.1016/j.intimp.2021.108306
   Liao CC, 2014, J SCI FOOD AGR, V94, P1154, DOI 10.1002/jsfa.6386
   Liss KHH, 2017, BIOCHIMIE, V136, P65, DOI 10.1016/j.biochi.2016.11.009
   Liu XJ, 2015, ENDOCRINOLOGY, V156, P2103, DOI 10.1210/en.2014-2037
   Liu YY, 2019, ACTA PHARM SIN B, V9, P745, DOI 10.1016/j.apsb.2019.02.006
   Liu YY, 2020, LIFE SCI, V241, DOI 10.1016/j.lfs.2019.117086
   Lonardo A, 2018, J HEPATOL, V68, P335, DOI 10.1016/j.jhep.2017.09.021
   Loomba R, 2020, HEPATOLOGY, V72, P1219, DOI 10.1002/hep.31121
   Lopez-Moreno J, 2018, J GERONTOL A-BIOL, V73, P340, DOI 10.1093/gerona/glw214
   Velázquez AM, 2022, MOL NUTR FOOD RES, V66, DOI 10.1002/mnfr.202101115
   Mahmoudi A, 2022, NUTRIENTS, V14, DOI 10.3390/nu14071331
   Majidzadeh H, 2020, COLLOID SURFACE B, V194, DOI 10.1016/j.colsurfb.2020.111188
   Malo FC, 2020, OBES SURG, V30, P5047, DOI 10.1007/s11695-020-04968-5
   Mantovani A, 2020, METABOLISM, V111, DOI 10.1016/j.metabol.2020.154170
   Marin V, 2017, NUTRIENTS, V9, DOI 10.3390/nu9091006
   Mato JM, 2019, WORLD J GASTROENTERO, V25, P3009, DOI 10.3748/wjg.v25.i24.3009
   Medina-Urrutia A, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-01283-x
   Méndez-del Villar M, 2014, METAB SYNDR RELAT D, V12, P497, DOI 10.1089/met.2014.0082
   Miyake T, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10102540
   Mofidi F, 2017, BRIT J NUTR, V117, P662, DOI 10.1017/S0007114517000204
   Mohammadi S, 2022, INT J CLIN PRACT, V2022, DOI 10.1155/2022/9925267
   Mokgalaboni K, 2021, FOOD FUNCT, V12, P12235, DOI [10.1039/d1fo02696h, 10.1039/D1FO02696H]
   Moreira GV, 2018, J NUTR BIOCHEM, V62, P143, DOI 10.1016/j.jnutbio.2018.07.009
   Moreira RJ, 2020, MOL NUTR FOOD RES, V64, DOI 10.1002/mnfr.201900833
   Mossanen JC, 2016, HEPATOLOGY, V64, P1667, DOI 10.1002/hep.28682
   Musazadeh V, 2021, INT J CLIN PRACT, V75, DOI 10.1111/ijcp.14744
   Muscogiuri G, 2014, EUR J ENDOCRINOL, V171, pR101, DOI 10.1530/EJE-14-0158
   Neuschwander-Tetri BA, 2015, LANCET, V385, P956, DOI 10.1016/S0140-6736(14)61933-4
   Newsome P, 2019, ALIMENT PHARM THER, V50, P193, DOI 10.1111/apt.15316
   Newsome PN, 2021, NEW ENGL J MED, V384, P1113, DOI 10.1056/NEJMoa2028395
   Nguyen NT, 2017, NAT REV GASTRO HEPAT, V14, P160, DOI 10.1038/nrgastro.2016.170
   Ni XJ, 2016, AM J TRANSL RES, V8, P1073
   Nobili V, 2018, J PEDIATR-US, V194, P100, DOI 10.1016/j.jpeds.2017.10.036
   Ortiz-López N, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.954869
   Ou Q, 2018, DIGEST DIS SCI, V63, P3398, DOI 10.1007/s10620-018-5268-0
   Pacifico L, 2014, MINI-REV MED CHEM, V14, P791
   Pan QL, 2019, BBA-MOL BASIS DIS, V1865, P525, DOI 10.1016/j.bbadis.2018.12.014
   Panahi Y, 2017, DRUG RES, V67, P244, DOI 10.1055/s-0043-100019
   Panahi Y, 2016, BIOMED PHARMACOTHER, V82, P578, DOI 10.1016/j.biopha.2016.05.037
   Panahi Y, 2015, CLIN NUTR, V34, P1101, DOI 10.1016/j.clnu.2014.12.019
   Papatheodoridi M, 2018, CURR PHARM DESIGN, V24, P4574, DOI 10.2174/1381612825666190117102111
   Pardo V, 2015, FOOD CHEM TOXICOL, V80, P298, DOI 10.1016/j.fct.2015.03.029
   Parker HM, 2012, J HEPATOL, V56, P944, DOI 10.1016/j.jhep.2011.08.018
   Pasavei AG, 2020, MALAYS J MED SCI, V27, P57, DOI 10.21315/mjms2020.27.1.6
   Pastori D, 2022, BRIT J CLIN PHARMACO, V88, P441, DOI 10.1111/bcp.14943
   Pereira ENGD, 2022, NUTRIENTS, V14, DOI 10.3390/nu14030716
   Peters JM, 2015, TRENDS ENDOCRIN MET, V26, P595, DOI 10.1016/j.tem.2015.09.004
   Petroni ML, 2021, BMJ-BRIT MED J, V372, DOI 10.1136/bmj.m4747
   Pittala S, 2019, MOL THER, V27, P1848, DOI 10.1016/j.ymthe.2019.06.017
   Porras D, 2017, FREE RADICAL BIO MED, V102, P188, DOI 10.1016/j.freeradbiomed.2016.11.037
   Powell EE, 2021, LANCET, V397, P2212, DOI 10.1016/S0140-6736(20)32511-3
   Presa N, 2019, BBA-MOL BASIS DIS, V1865, P14, DOI 10.1016/j.bbadis.2018.10.010
   Rahmani S, 2016, PHYTOTHER RES, V30, P1540, DOI 10.1002/ptr.5659
   Ratziu V, 2020, HEPATOLOGY, V72, P892, DOI 10.1002/hep.31108
   Ratziu V, 2016, GASTROENTEROLOGY, V150, P1147, DOI 10.1053/j.gastro.2016.01.038
   Rau M, 2021, EXPERT REV CLIN PHAR, V14, P333, DOI 10.1080/17512433.2021.1884068
   Rey E, 2020, LIVER INT, V40, P2553, DOI 10.1111/liv.14519
   Rodrigues PO, 2014, BRIT J NUTR, V112, P309, DOI 10.1017/S0007114514000853
   Romero-Gómez M, 2017, J HEPATOL, V67, P829, DOI 10.1016/j.jhep.2017.05.016
   Rotman Y, 2017, GUT, V66, P180, DOI 10.1136/gutjnl-2016-312431
   Russo MF, 2021, J CLIN ENDOCR METAB, V106, P750, DOI 10.1210/clinem/dgaa892
   Saha S, 2016, BIOFACTORS, V42, P459, DOI 10.1002/biof.1292
   Sahebkar A, 2014, EXPERT OPIN PHARMACO, V15, P493, DOI 10.1517/14656566.2014.876992
   Santos-Sánchez G, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10081222
   Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929
   Sebastiani G, 2020, AIDS, V34, P237, DOI 10.1097/QAD.0000000000002412
   Seo SH, 2022, GASTROENTEROL REP, V10, DOI 10.1093/gastro/goac037
   Sfikas G, 2021, CURR VASC PHARMACOL, V19, P572, DOI 10.2174/1570161118666201015152921
   Sharifi N, 2014, ENDOCRINE, V47, P70, DOI 10.1007/s12020-014-0336-5
   Sharifi-Rad J, 2023, Z NATURFORSCH C, V78, P9, DOI 10.1515/znc-2022-0076
   Sharma L, 2018, FOOD CHEM TOXICOL, V121, P283, DOI 10.1016/j.fct.2018.09.011
   Shim P, 2017, ANN NUTR METAB, V70, P303, DOI 10.1159/000475605
   Silva-Veiga FM, 2018, MOL CELL ENDOCRINOL, V474, P227, DOI 10.1016/j.mce.2018.03.013
   Smíd V, 2022, HEPATOL COMMUN, V6, P1336, DOI 10.1002/hep4.1906
   Suk KT, 2019, EXPERT REV GASTROENT, V13, P193, DOI 10.1080/17474124.2019.1569513
   Sumida Y, 2018, J GASTROENTEROL, V53, P362, DOI 10.1007/s00535-017-1415-1
   Sun YX, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-11860-3
   Tacke F, 2018, EXPERT OPIN INV DRUG, V27, P301, DOI 10.1080/13543784.2018.1442436
   Talavera-Urquijo E, 2020, SURG OBES RELAT DIS, V16, P1361, DOI 10.1016/j.soard.2020.03.013
   Tao L, 2022, MOLECULES, V27, DOI 10.3390/molecules27134275
   Tapia G, 2014, MOL NUTR FOOD RES, V58, P1333, DOI 10.1002/mnfr.201300458
   Targher G, 2018, NAT REV ENDOCRINOL, V14, P99, DOI 10.1038/nrendo.2017.173
   Tejada S, 2021, CURR PHARM DESIGN, V27, P2558, DOI 10.2174/1381612826666200417165801
   Torres-Collado L, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.997975
   Tosti V, 2018, J GERONTOL A-BIOL, V73, P318, DOI 10.1093/gerona/glx227
   Uribarri J, 2015, ADV NUTR, V6, P461, DOI 10.3945/an.115.008433
   Van Dalem J, 2021, HEPATOLOGY, V74, P2467, DOI 10.1002/hep.32012
   van der Veen JN, 2016, AM J PHYSIOL-GASTR L, V310, pG526, DOI 10.1152/ajpgi.00243.2015
   Vilar-Gomez E, 2015, GASTROENTEROLOGY, V149, P367, DOI 10.1053/j.gastro.2015.04.005
   Vivoli E, 2016, CLIN SCI, V130, P1793, DOI 10.1042/CS20160400
   Wang M, 2019, CRIT REV FOOD SCI, V59, pS116, DOI 10.1080/10408398.2018.1544542
   Wang QQ, 2021, NUTR J, V20, DOI 10.1186/s12937-021-00690-9
   Wei XY, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/3593951
   Wettstein G, 2017, HEPATOL COMMUN, V1, P524, DOI 10.1002/hep4.1057
   Wong VWS, 2018, J HEPATOL, V69, P1349, DOI 10.1016/j.jhep.2018.08.011
   Woodhouse CA, 2018, ALIMENT PHARM THER, V47, P192, DOI 10.1111/apt.14397
   Xie ZQ, 2022, FRONT NUTR, V8, DOI 10.3389/fnut.2021.795391
   Xin JY, 2022, BMC MED, V20, DOI 10.1186/s12916-022-02366-5
   Xu XH, 2022, SIGNAL TRANSDUCT TAR, V7, DOI 10.1038/s41392-022-01119-3
   Xue L, 2017, SCI REP-UK, V7, DOI 10.1038/srep45176
   Yaghoubi M, 2017, EUR J GASTROEN HEPAT, V29, P1385, DOI 10.1097/MEG.0000000000000981
   Yang H, 2019, PHYTOTHER RES, V33, P3140, DOI 10.1002/ptr.6486
   Yang MY, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00432
   Yao ZC, 2022, J FUNCT FOODS, V93, DOI 10.1016/j.jff.2022.105063
   Yarahmadi S, 2023, DNA CELL BIOL, V42, P82, DOI 10.1089/dna.2022.0581
   Ye JN, 2022, MAR DRUGS, V20, DOI 10.3390/md20050312
   Younossi ZM, 2022, CLIN GASTROENTEROL H, V20, P2050, DOI 10.1016/j.cgh.2021.07.020
   Younossi ZM, 2019, J HEPATOL, V71, P793, DOI 10.1016/j.jhep.2019.06.021
   Yu HH, 2019, DIABET METAB SYND OB, V12, P149, DOI 10.2147/DMSO.S190631
   Zelber-Sagi S, 2017, LIVER INT, V37, P936, DOI 10.1111/liv.13435
   Zeng YL, 2020, AM J PHYSIOL-GASTR L, V318, pG542, DOI 10.1152/ajpgi.00286.2019
   Zhan Z, 2019, PEERJ, V7, DOI 10.7717/peerj.6645
   Zhang HJ, 2017, DIABETES OBES METAB, V19, P284, DOI 10.1111/dom.12809
   Zhang JL, 2017, CHEM-BIOL INTERACT, V278, P189, DOI 10.1016/j.cbi.2017.10.010
   Zhang N, 2015, PHARMACOLOGY, V95, P173, DOI 10.1159/000380952
   Zhang XL, 2022, DIABETES METAB J, V46, P391, DOI 10.4093/dmj.2022.0048
   Zhang X, 2015, SCI REP-UK, V5, DOI 10.1038/srep14405
   Zhang Y, 2021, J IMMUNOL RES, V2021, DOI 10.1155/2021/4084566
   Zhao JV, 2021, NUTRIENTS, V13, DOI 10.3390/nu13082550
   Zhong DD, 2018, CELL PHYSIOL BIOCHEM, V49, P1204, DOI 10.1159/000493297
   Zhu XP, 2019, FREE RADICAL BIO MED, V141, P192, DOI 10.1016/j.freeradbiomed.2019.06.019
   Zhu XH, 2018, FOOD CHEM TOXICOL, V114, P52, DOI 10.1016/j.fct.2018.02.019
NR 231
TC 4
Z9 4
U1 8
U2 21
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD OCT
PY 2024
VL 54
IS 4
AR 88
DI 10.3892/ijmm.2024.5412
PG 15
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA D3X1E
UT WOS:001295538200001
PM 39129305
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Remels, AH
   Gosker, HR
   Schrauwen, P
   Langen, RC
   Schols, AM
AF Remels, A. H.
   Gosker, H. R.
   Schrauwen, P.
   Langen, R. C.
   Schols, A. M.
TI Peroxisome proliferator-activated receptors: a therapeutic target in
   COPD?
SO EUROPEAN RESPIRATORY JOURNAL
LA English
DT Article
DE chronic obstructive pulmonary disease; inflammation; oxidative stress;
   peroxisome proliferator-activated receptors; skeletal muscle
ID OBSTRUCTIVE PULMONARY-DISEASE; NF-KAPPA-B; FATTY-ACID CATABOLISM; DELTA
   PPAR-DELTA; SKELETAL-MUSCLE; NITRIC-OXIDE; OXIDATIVE STRESS; METABOLIC
   SYNDROME; INFLAMMATORY RESPONSES; ALPHA ACTIVATION
AB Extrapulmonary pathology significantly impairs clinical outcome in chronic obstructive pulmonary disease (COPD).
   The peroxisome proliferator-activated receptors (PPARs) are implicated in the regulation of several hallmarks of systemic COPD pathology, including cachexia, decreased oxidative muscle metabolism, oxidative stress and systemic inflammation.
   Recently, expression of PPARs and related cofactors was shown to be reduced in peripheral skeletal muscle of patients with moderate-to-severe COPD and muscle weakness.
   The current authors hypothesise that impaired peroxisome proliferator-activated receptor signalling may underlie some of the muscular disturbances in chronic obstructive pulmonary disease. Proposed mechanisms will be outlined in the present article, as well as the therapeutic potential of peroxisome proliferator-activated receptor modulation in the treatment of skeletal muscle dysfunction.
C1 [Remels, A. H.; Gosker, H. R.; Langen, R. C.; Schols, A. M.] Univ Maastricht, Dept Resp Med, NUTRIM Sch Nutr Toxicol & Metab, NL-6202 AZ Maastricht, Netherlands.
   [Schrauwen, P.] Univ Maastricht, Dept Human Biol, NUTRIM Sch Nutr Toxicol & Metab, NL-6202 AZ Maastricht, Netherlands.
C3 Maastricht University; Maastricht University Medical Centre (MUMC);
   Maastricht University; Maastricht University Medical Centre (MUMC)
RP Remels, AH (corresponding author), Univ Maastricht, Dept Resp Med, NUTRIM Sch Nutr Toxicol & Metab, POB 5800, NL-6202 AZ Maastricht, Netherlands.
EM a.remels@pul.unimaas.nl
RI Remels, Alexander/NBX-8148-2025; schrauwen, patrick/KRR-1274-2024
OI Gosker, Harry/0000-0002-7659-0225; schrauwen,
   patrick/0000-0002-0973-847X
CR Agustí A, 2004, THORAX, V59, P483, DOI 10.1136/thx.2003.017640
   Agusti Alvar G N, 2005, Proc Am Thorac Soc, V2, P367, DOI 10.1513/pats.200504-026SR
   Akiyama Taro E, 2005, Curr Diab Rep, V5, P45, DOI 10.1007/s11892-005-0067-3
   Balasubramanian VP, 2006, CURR OPIN PULM MED, V12, P106, DOI 10.1097/01.mcp.0000208449.73101.ac
   Baldán A, 2004, NUCLEIC ACIDS RES, V32, P4742, DOI 10.1093/nar/gkh806
   Barreiro E, 2003, AM J RESP CELL MOL, V29, P771, DOI 10.1165/rcmb.2003-0138OC
   Barreiro E., 2007, Thorax
   Becker J, 2006, FUND CLIN PHARMACOL, V20, P429, DOI 10.1111/j.1472-8206.2006.00425.x
   Beltowski J, 2002, J PHYSIOL PHARMACOL, V53, P463
   Blanquart C, 2003, J STEROID BIOCHEM, V85, P267, DOI 10.1016/S0960-0760(03)00214-0
   Broekhuizen R, 2005, THORAX, V60, P376, DOI 10.1136/thx.2004.030858
   Buck M, 1996, EMBO J, V15, P1753, DOI 10.1002/j.1460-2075.1996.tb00524.x
   Cai DS, 2004, CELL, V119, P285, DOI 10.1016/j.cell.2004.09.027
   Carey AL, 2006, DIABETOLOGIA, V49, P1000, DOI 10.1007/s00125-006-0178-7
   Castrillo A, 2000, MOL CELL BIOL, V20, P1692, DOI 10.1128/MCB.20.5.1692-1698.2000
   Chawla A, 2001, NAT MED, V7, P48, DOI 10.1038/83336
   Cresci S, 1996, AM J PHYSIOL-CELL PH, V270, pC1413, DOI 10.1152/ajpcell.1996.270.5.C1413
   Dandona P, 2002, AM J CARDIOL, V90, p27G
   de Lange P, 2004, FASEB J, V18, DOI 10.1096/fj.03-0342fje
   de Oca MM, 2005, EUR RESPIR J, V26, P390, DOI 10.1183/09031936.05.00107404
   Delayre-Orthez C, 2005, RESP RES, V6, DOI 10.1186/1465-9921-6-91
   Delerive P, 2001, J ENDOCRINOL, V169, P453, DOI 10.1677/joe.0.1690453
   Doherty Dennis E, 2004, Clin Cornerstone, VSuppl 2, pS29
   Fredenrich A, 2004, CURR OPIN CLIN NUTR, V7, P377, DOI 10.1097/01.mco.0000134370.93686.0a
   Fritz T, 2006, DIABETES-METAB RES, V22, P492, DOI 10.1002/dmrr.656
   Garnier A, 2003, J PHYSIOL-LONDON, V551, P491, DOI 10.1113/jphysiol.2003.045104
   Girnun GD, 2002, MOL ENDOCRINOL, V16, P2793, DOI 10.1210/me.2002-0020
   Gosker HR, 2007, THORAX, V62, P944, DOI 10.1136/thx.2007.078980
   Gosker HR, 2003, EUR RESPIR J, V22, P280, DOI 10.1183/09031936.03.00012803
   Grimaldi PA, 2003, BIOCHEM SOC T, V31, P1130
   Guttridge DC, 2000, SCIENCE, V289, P2363, DOI 10.1126/science.289.5488.2363
   Harris RA, 2004, BIOCHEM BIOPH RES CO, V313, P391, DOI 10.1016/j.bbrc.2003.11.007
   Holst D, 2003, BBA-MOL CELL BIOL L, V1633, P43, DOI 10.1016/S1388-1981(03)00071-4
   Horowitz JF, 2000, AM J PHYSIOL-ENDOC M, V279, pE348, DOI 10.1152/ajpendo.2000.279.2.E348
   Inoue I, 1998, LIFE SCI, V63, P135, DOI 10.1016/S0024-3205(98)00249-5
   Jiang CY, 1998, NATURE, V391, P82, DOI 10.1038/34184
   Jobgen WS, 2006, J NUTR BIOCHEM, V17, P571, DOI 10.1016/j.jnutbio.2005.12.001
   Kersten S, 2000, NATURE, V405, P421, DOI 10.1038/35013000
   Koechlin C, 2004, EUR RESPIR J, V23, P538, DOI 10.1183/09031936.04.00069004
   Langen RCJ, 2006, AM J RESP CELL MOL, V35, P689, DOI 10.1165/rcmb.2006-0103OC
   Langen RCJ, 2002, AM J PHYSIOL-CELL PH, V283, pC714, DOI 10.1152/ajpcell.00418.2001
   Langen RCJ, 2001, FASEB J, V15, P1169, DOI 10.1096/fj.00-0463
   Leone TC, 1999, P NATL ACAD SCI USA, V96, P7473, DOI 10.1073/pnas.96.13.7473
   Li M, 2000, MOL CELL BIOL, V20, P4699, DOI 10.1128/MCB.20.13.4699-4707.2000
   Lin J, 2002, NATURE, V418, P797, DOI 10.1038/nature00904
   Luquet S, 2004, BIOCHIMIE, V86, P833, DOI 10.1016/j.biochi.2004.09.024
   Luquet S, 2003, FASEB J, V17, P2299, DOI 10.1096/fj.03-0269fje
   Luquet S, 2005, BBA-MOL BASIS DIS, V1740, P313, DOI 10.1016/j.bbadis.2004.11.011
   MacNee W, 2000, CHEST, V117, p303S, DOI 10.1378/chest.117.5_suppl_1.303S-a
   MacNee William, 2005, Current Drug Targets - Inflammation and Allergy, V4, P627, DOI 10.2174/156801005774912815
   Mador MJ, 2002, AM J RESP CRIT CARE, V166, P787, DOI 10.1164/rccm.2206003
   Maltais F, 1996, AM J RESP CRIT CARE, V154, P442, DOI 10.1164/ajrccm.154.2.8756820
   Muoio DM, 2002, J BIOL CHEM, V277, P26089, DOI 10.1074/jbc.M203997200
   Narravula S, 2001, J IMMUNOL, V166, P7543, DOI 10.4049/jimmunol.166.12.7543
   Nisoli E, 2003, SCIENCE, V299, P896, DOI 10.1126/science.1079368
   Poynter ME, 1998, J BIOL CHEM, V273, P32833, DOI 10.1074/jbc.273.49.32833
   Rabe KF, 2007, AM J RESP CRIT CARE, V176, P532, DOI 10.1164/rccm.200703-456SO
   Rabinovich RA, 2007, EUR RESPIR J, V29, P643, DOI 10.1183/09031936.00086306
   Remels AH, 2007, EUR RESPIR J, V30, P245, DOI 10.1183/09031936.00144106
   Rieusset J, 2002, MOL ENDOCRINOL, V16, P2628, DOI 10.1210/me.2002-0036
   Roden M, 2005, INT J OBESITY, V29, pS111, DOI 10.1038/sj.ijo.0803102
   Sandri M, 2006, P NATL ACAD SCI USA, V103, P16260, DOI 10.1073/pnas.0607795103
   Satta A, 1997, EUR RESPIR J, V10, P2853, DOI 10.1183/09031936.97.10122853
   Schulz R, 2007, AM J PHYSIOL-HEART C, V293, pH11, DOI 10.1152/ajpheart.00345.2007
   Shiojiri T, 2002, EUR J PHARMACOL, V448, P231, DOI 10.1016/S0014-2999(02)01946-5
   Spears M, 2006, CLIN EXP ALLERGY, V36, P1494, DOI 10.1111/j.1365-2222.2006.02604.x
   Staels B, 1998, NATURE, V393, P790, DOI 10.1038/31701
   Stangel M, 1996, J NEUROPATH EXP NEUR, V55, P36, DOI 10.1097/00005072-199601000-00004
   Sung CK, 2004, AM J PHYSIOL-GASTR L, V286, pG722, DOI 10.1152/ajpgi.00411.2003
   Takahashi M, 2002, AM J PHYSIOL-GASTR L, V282, pG338, DOI 10.1152/ajpgi.00376.2001
   Tanaka T, 2003, P NATL ACAD SCI USA, V100, P15924, DOI 10.1073/pnas.0306981100
   Tao L, 2003, CIRCULATION, V108, P2805, DOI 10.1161/01.CIR.0000097003.49585.5E
   Tham DM, 2002, PHYSIOL GENOMICS, V11, P21, DOI 10.1152/physiolgenomics.00062.2002
   Toyama T, 2004, BIOCHEM BIOPH RES CO, V324, P697, DOI 10.1016/j.bbrc.2004.09.110
   Vergès B, 2004, DIABETES METAB, V30, P7, DOI 10.1016/S1262-3636(07)70083-6
   Wang YX, 2003, CELL, V113, P159, DOI 10.1016/S0092-8674(03)00269-1
   Woo CH, 2006, J BIOL CHEM, V281, P32164, DOI 10.1074/jbc.M602369200
   Xiao CC, 2005, ADV EXP MED BIOL, V560, P41
NR 78
TC 34
Z9 38
U1 0
U2 7
PU EUROPEAN RESPIRATORY SOC JOURNALS LTD
PI SHEFFIELD
PA 442 GLOSSOP RD, SHEFFIELD S10 2PX, ENGLAND
SN 0903-1936
EI 1399-3003
J9 EUR RESPIR J
JI Eur. Resp. J.
PD MAR
PY 2008
VL 31
IS 3
BP 502
EP 508
DI 10.1183/09031936.00068207
PG 7
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA 272RA
UT WOS:000253876000005
PM 18310397
OA Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Mahmoud, AAA
   Elshazly, SM
AF Mahmoud, Amr A. A.
   Elshazly, Shimaa M.
TI Ursodeoxycholic Acid Ameliorates Fructose-Induced Metabolic Syndrome in
   Rats
SO PLOS ONE
LA English
DT Article
ID IMPROVES INSULIN SENSITIVITY; CORONARY-HEART-DISEASE; FATTY
   LIVER-DISEASE; ENDOTHELIAL DYSFUNCTION; NITRIC-OXIDE; HYPERTENSIVE-RATS;
   DIETARY FRUCTOSE; OXIDATIVE STRESS; RESISTANCE; FENOFIBRATE
AB The metabolic syndrome (MS) is characterized by insulin resistance, dyslipidemia and hypertension. It is associated with increased risk of cardiovascular diseases and type-2 diabetes. Consumption of fructose is linked to increased prevalence of MS. Ursodeoxycholic acid (UDCA) is a steroid bile acid with antioxidant, anti-inflammatory activities and has been shown to improve insulin resistance. The current study aims to investigate the effect of UDCA (150 mg/kg) on MS induced in rats by fructose administration (10%) in drinking water for 12 weeks. The effects of UDCA were compared to fenofibrate (100 mg/kg), an agonist of PPAR-a receptors. Treatment with UDCA or fenofibrate started from the 6 th week after fructose administration once daily. Fructose administration resulted in significant increase in body weight, elevations of blood glucose, serum insulin, cholesterol, triglycerides, advanced glycation end products (AGEs), uric acid levels, insulin resistance index and blood pressure compared to control rats. Moreover, fructose increased oxidative stress in aortic tissues indicated by significant increases of malondialdehyde (MDA), expression of iNOS and reduction of reduced glutathione (GSH) content. These disturbances were associated with decreased eNOS expression, increased infiltration of leukocytes and loss of aortic vascular elasticity. Treatment with UDCA successfully ameliorated the deleterious effects of fructose. The protective effect of UDCA could be attributed to its ability to decrease uric acid level, improve insulin resistance and diminish oxidative stress in vascular tissues. These results might support possible clinical application of UDCA in MS patients especially those present with liver diseases, taking into account its tolerability and safety. However, further investigations on human subjects are needed before the clinical application of UDCA for this indication.
C1 [Mahmoud, Amr A. A.; Elshazly, Shimaa M.] Zagazig Univ, Fac Pharm, Dept Pharmacol, Zagazig, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University
RP Elshazly, SM (corresponding author), Zagazig Univ, Fac Pharm, Dept Pharmacol, Zagazig, Egypt.
EM shimaa_elshazly@yahoo.com
RI Mahmoud, Amr/Y-7062-2019
OI Mahmoud, Amr/0000-0003-2959-0692
CR Angulo Paul, 2002, Curr Gastroenterol Rep, V4, P37, DOI 10.1007/s11894-002-0036-9
   Ardestani A, 2007, INT J BIOL MACROMOL, V41, P572, DOI 10.1016/j.ijbiomac.2007.07.014
   Beckman JS, 1996, AM J PHYSIOL-CELL PH, V271, pC1424
   BEUTLER E, 1963, J LAB CLIN MED, V61, P882
   Bray GA, 2004, AM J CLIN NUTR, V79, P537
   Cavarape A, 2001, J ENDOCRINOL INVEST, V24, P838, DOI 10.1007/BF03343940
   Chou CL, 2011, ARCH MED SCI, V7, P882, DOI 10.5114/aoms.2011.25566
   Comar KM, 2006, ALIMENT PHARM THER, V23, P207, DOI 10.1111/j.1365-2036.2006.02751.x
   DECAESTECKER JS, 1991, GUT, V32, P1061, DOI 10.1136/gut.32.9.1061
   Delbosc S, 2005, ATHEROSCLEROSIS, V179, P43, DOI 10.1016/j.atherosclerosis.2004.10.018
   Elliott SS, 2002, AM J CLIN NUTR, V76, P911, DOI 10.1093/ajcn/76.5.911
   Goldin A, 2006, CIRCULATION, V114, P597, DOI 10.1161/CIRCULATIONAHA.106.621854
   Guerre-Millo M, 2000, J BIOL CHEM, V275, P16638, DOI 10.1074/jbc.275.22.16638
   HALLFRISCH J, 1990, FASEB J, V4, P2652, DOI 10.1096/fasebj.4.9.2189777
   Hempfling W, 2003, ALIMENT PHARM THER, V18, P963, DOI 10.1046/j.1365-2036.2003.01792.x
   Hink U, 2001, CIRC RES, V88, pE14
   Ho Chiu-Yung, 2004, J Chin Med Assoc, V67, P245
   Hodel C, 2002, TOXICOL LETT, V128, P159, DOI 10.1016/S0378-4274(02)00010-3
   HULMAN S, 1994, PEDIATR RES, V36, P95, DOI 10.1203/00006450-199407001-00017
   Hunt KJ, 2004, CIRCULATION, V110, P1251, DOI 10.1161/01.CIR.0000140762.04598.F9
   HWANG IS, 1987, HYPERTENSION, V10, P512, DOI 10.1161/01.HYP.10.5.512
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   IYER SN, 1994, LIFE SCI, V55, pPL139, DOI 10.1016/0024-3205(94)00750-0
   Juan CC, 1998, J HYPERTENS, V16, P1775, DOI 10.1097/00004872-199816120-00010
   Kars M, 2010, DIABETES, V59, P1899, DOI 10.2337/db10-0308
   Khosla UM, 2005, KIDNEY INT, V67, P1739, DOI 10.1111/j.1523-1755.2005.00273.x
   Koh KK, 2005, DIABETES CARE, V28, P1419, DOI 10.2337/diacare.28.6.1419
   Kondrackiene J, 2005, GASTROENTEROLOGY, V129, P894, DOI 10.1053/j.gastro.2005.06.019
   Laville M, 2009, OBES REV, V10, P24, DOI 10.1111/j.1467-789X.2008.00562.x
   Lê KA, 2006, CURR OPIN CLIN NUTR, V9, P469, DOI 10.1097/01.mco.0000232910.61612.4d
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   Lorenzo C, 2003, DIABETES CARE, V26, P3153, DOI 10.2337/diacare.26.11.3153
   Luketic V A, 1994, Gastroenterologist, V2, P74
   Ma J, 2003, EUR J PHARMACOL, V464, P79, DOI 10.1016/S0014-2999(03)01373-6
   Mahmoud MF, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0063784
   Mahmoud MF, 2012, ARCH PHARM RES, V35, P155, DOI 10.1007/s12272-012-0117-8
   Makino I, 1998, J GASTROEN HEPATOL, V13, P659, DOI 10.1111/j.1440-1746.1998.tb00707.x
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Matsui HR, 1997, DIABETES, V46, P348, DOI 10.2337/diabetes.46.3.348
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Miller A, 2008, CURR OPIN GASTROEN, V24, P204, DOI 10.1097/MOG.0b013e3282f3f4c4
   Miller AW, 1999, J VASC RES, V36, P385, DOI 10.1159/000025678
   Nakagawa T, 2005, NAT CLIN PRACT NEPHR, V1, P80, DOI 10.1038/ncpneph0019
   Nakagawa T, 2006, AM J PHYSIOL-RENAL, V290, pF625, DOI 10.1152/ajprenal.00140.2005
   Okada M, 2009, TOXICOL PATHOL, V37, P517, DOI 10.1177/0192623309336151
   Polizio AH, 2006, CLIN EXP PHARMACOL P, V33, P734, DOI 10.1111/j.1440-1681.2006.04426.x
   Ratziu V, 2011, J HEPATOL, V54, P1011, DOI 10.1016/j.jhep.2010.08.030
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   RIGAL J, 1989, REV MED INTERNE, V10, P65, DOI 10.1016/S0248-8663(89)80119-5
   Roy D, 1998, AM J PHYSIOL-ENDOC M, V274, pE692, DOI 10.1152/ajpendo.1998.274.4.E692
   Ryan KE, 2007, ATHEROSCLEROSIS, V194, pE123, DOI 10.1016/j.atherosclerosis.2006.11.007
   Sampathkumar R, 2005, METABOLISM, V54, P1002, DOI 10.1016/j.metabol.2005.02.017
   Sánchez-Lozada LG, 2008, AM J PHYSIOL-RENAL, V294, pF710, DOI 10.1152/ajprenal.00454.2007
   Sanchez-Lozada LG, 2007, AM J PHYSIOL-RENAL, V292, pF423, DOI 10.1152/ajprenal.00124.2006
   SATOH K, 1978, CLIN CHIM ACTA, V90, P37
   Shinozaki K, 1999, DIABETES, V48, P2437, DOI 10.2337/diabetes.48.12.2437
   Sinisalo J, 1999, BRIT J CLIN PHARMACO, V47, P661, DOI 10.1046/j.1365-2125.1999.00940.x
   Sokolovic D, 2013, DRUG CHEM TOXICOL, V36, P141, DOI 10.3109/01480545.2012.658919
   Spiekermann S, 2003, CIRCULATION, V107, P1383, DOI 10.1161/01.CIR.0000056762.69302.46
   Tabernero Antonia, 2002, BMC Pharmacol, V2, P10, DOI 10.1186/1471-2210-2-10
   Tessari P, 2009, NUTR METAB CARDIOVAS, V19, P291, DOI 10.1016/j.numecd.2008.12.015
   Thirunavukkarasu V, 2004, NUTR METAB CARDIOVAS, V14, P351, DOI 10.1016/S0939-4753(04)80025-5
   TOBEY TA, 1982, METABOLISM, V31, P608, DOI 10.1016/0026-0495(82)90100-7
   Tran LT, 2009, MOL CELL BIOCHEM, V332, P145, DOI 10.1007/s11010-009-0184-4
   Tsuchida T, 2012, METABOLISM, V61, P944, DOI 10.1016/j.metabol.2011.10.023
   Ülker S, 2003, CARDIOVASC RES, V59, P488, DOI 10.1016/S0008-6363(03)00424-3
   Vamecq J, 1999, LANCET, V354, P141, DOI 10.1016/S0140-6736(98)10364-1
   Verma S, 1999, EUR J PHARMACOL, V373, pR1, DOI 10.1016/S0014-2999(99)00301-5
   Vlassara H, 2001, DIABETES-METAB RES, V17, P436, DOI 10.1002/dmrr.233
   Ye JM, 2001, DIABETES, V50, P411, DOI 10.2337/diabetes.50.2.411
   Zimmet P, 2001, NATURE, V414, P782, DOI 10.1038/414782a
NR 71
TC 55
Z9 58
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 9
PY 2014
VL 9
IS 9
AR e106993
DI 10.1371/journal.pone.0106993
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AQ3IF
UT WOS:000342684500059
PM 25202970
OA Green Published, Green Submitted, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Bourebaba, L
   Bedjou, F
   Röcken, M
   Marycz, K
AF Bourebaba, Lynda
   Bedjou, Fatiha
   Roecken, Michael
   Marycz, Krzysztof
TI Nortropane alkaloids as pharmacological chaperones in the rescue of
   equine adipose-derived mesenchymal stromal stem cells affected by
   metabolic syndrome through mitochondrial potentiation, endoplasmic
   reticulum stress mitigation and insulin resistance alleviation
SO STEM CELL RESEARCH & THERAPY
LA English
DT Article
DE EMS; ASCs; Hyoscyamus albus; Calystegines; Iminosugars; Insulin
   resistance
ID OXIDATIVE STRESS; GENE-EXPRESSION; CALYSTEGINES; APOPTOSIS; AUTOPHAGY;
   DIFFERENTIATION; DYSFUNCTION; IMINOSUGARS; INHIBITION; MECHANISMS
AB ObjectivesEquine metabolic syndrome (EMS) refers to a cluster of associated abnormalities and metabolic disorders, including insulin resistance and adiposity. The numerous biological properties of mesenchymal stem cells (MSCs), including self-renewal and multipotency, have been the subject of many in-depth studies, for the management of EMS; however, it has been shown that this cell type may be affected by the condition, impairing thus seriously their therapeutic potential. Therefore, an attempt to rescue EMS adipose-derived stem cells (ASCs) with calystegines (polyhydroxylated alkaloids) that are endowed with strong antioxidant and antidiabetic abilities was performed.MethodsASCs isolated from EMS horses were subsequently treated with various concentrations of total calystegines. Different parameters were then assessed using flow cytometry, confocal as well as SE microscopy, and RT-qPCR.ResultsOur results clearly demonstrated that calystegines could improve EqASC viability and proliferation and significantly reduce apoptosis, via improvement of mitochondrial potentiation and functionality, regulation of pro- and anti-apoptotic pathways, and suppression of ER stress. Furthermore, nortropanes positively upregulated GLUT4 and IRS transcripts, indicating a possible sensitizing or mimetic effect to insulin. Most interesting finding in this investigation lies in the modulatory effect of autophagy, a process that allows the maintenance of cellular homeostasis; calystegines acted as pharmacological chaperones to promote cell survival.ConclusionObtained data open new perspectives in the development of new drugs, which may improve the metabolic dynamics of cells challenged by MS.
C1 [Bourebaba, Lynda; Marycz, Krzysztof] Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, Norwida 27B, PL-50375 Wroclaw, Poland.
   [Roecken, Michael; Marycz, Krzysztof] Justus Liebig Univ, Equine Clin Equine Surg, Fac Vet Med, D-35392 Giessen, Germany.
   [Bedjou, Fatiha] Univ Bejaia, Fac Sci Nat & Vie, Lab Biotechnol Vegetales & Ethnobot, Bejaia, Algeria.
   [Bourebaba, Lynda; Marycz, Krzysztof] Int Inst Translat Med, Jesionowa 11, PL-55114 Malin, Wisznia Mala, Poland.
C3 Wroclaw University of Environmental & Life Sciences; Justus Liebig
   University Giessen; Universite de Bejaia
RP Bourebaba, L; Marycz, K (corresponding author), Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, Norwida 27B, PL-50375 Wroclaw, Poland.; Marycz, K (corresponding author), Justus Liebig Univ, Equine Clin Equine Surg, Fac Vet Med, D-35392 Giessen, Germany.; Bourebaba, L; Marycz, K (corresponding author), Int Inst Translat Med, Jesionowa 11, PL-55114 Malin, Wisznia Mala, Poland.
EM lynda.bourebaba@upwr.edu.pl; krzysztof.marycz@upwr.edu.pl
RI Bourebaba, Lynda/AAX-7613-2020
FU National Science Centre in Poland [2016/21/B/NZ7/01111]
FX This project is financed in the framework of the grant entitled
   "Modulation mitochondrial metabolism and dynamics and targeting DNA
   methylation of adipose-derived mesenchymal stromal stem cell (ASC) using
   RES and 5-azacytydin as a therapeutic strategy in the course of EMS"
   (grant no. 2016/21/B/NZ7/01111) attributed by The National Science
   Centre in Poland.
CR Aerts JM, 2007, DIABETES, V56, P1341, DOI 10.2337/db06-1619
   [Anonymous], ISRN CELL BIOL
   Argo C., 2015, Acta Vet Scand, V57, pK2, DOI [10.1186/1751-0147-57-S1-K2, DOI 10.1186/1751-0147-57-S1-K2]
   Asano N, 1997, EUR J BIOCHEM, V248, P296, DOI 10.1111/j.1432-1033.1997.00296.x
   Bhatti JS, 2017, BBA-MOL BASIS DIS, V1863, P1066, DOI 10.1016/j.bbadis.2016.11.010
   Bourebaba L, 2016, IND CROP PROD, V89, P316, DOI 10.1016/j.indcrop.2016.04.067
   Bourebaba L, 2016, BIOMED PHARMACOTHER, V82, P337, DOI 10.1016/j.biopha.2016.05.011
   Brunelle JK, 2009, J CELL SCI, V122, P437, DOI 10.1242/jcs.031682
   Chakraborty C, 2006, CURR PROTEIN PEPT SC, V7, P113, DOI 10.2174/138920306776359759
   Clément K, 2004, FASEB J, V18, P1657, DOI 10.1096/fj.04-2204com
   Del Bue M, 2008, VET RES COMMUN, V32, pS51, DOI 10.1007/s11259-008-9093-3
   Frank N, 2010, J VET INTERN MED, V24, P467, DOI 10.1111/j.1939-1676.2010.0503.x
   Geor RJ, 2008, J EQUINE VET SCI, V28, P753, DOI 10.1016/j.jevs.2008.10.016
   Harper ME, 2004, ACTA PHYSIOL SCAND, V182, P321, DOI 10.1111/j.1365-201X.2004.01370.x
   Hu CX, 2018, J CELL MOL MED, V22, P1428, DOI 10.1111/jcmm.13492
   Hu F, 2011, CELL SIGNAL, V23, P1528, DOI 10.1016/j.cellsig.2011.05.008
   Johnson P. J., 2004, Compendium on Continuing Education for the Practicing Veterinarian, V26, P122
   Kastelan M, 2009, ACTA DERMATOVENER CR, V17, P182
   Kato A, 2014, BIOORGAN MED CHEM, V22, P2435, DOI 10.1016/j.bmc.2014.02.057
   Kim JB, 2017, INT J ANTENN PROPAG, V2017, DOI 10.1155/2017/1862391
   Kim KH, 2014, NAT REV ENDOCRINOL, V10, P322, DOI 10.1038/nrendo.2014.35
   King K, 2015, J BIOL CHEM, V290, P26235, DOI 10.1074/jbc.M115.672097
   Kowaltowski AJ, 2009, FREE RADICAL BIO MED, V47, P333, DOI 10.1016/j.freeradbiomed.2009.05.004
   Kvasnicka F, 2008, J CHROMATOGR A, V1181, P137, DOI 10.1016/j.chroma.2007.12.037
   Lamothe B, 1998, BIOCHEM J, V335, P193, DOI 10.1042/bj3350193
   Lee HK, 2010, BBA-GEN SUBJECTS, V1800, P282, DOI 10.1016/j.bbagen.2009.11.010
   Lee J, 2014, J BIOL CHEM, V289, P1203, DOI 10.1074/jbc.R113.534743
   Li JP, 2002, AM J PHYSIOL-ENDOC M, V282, pE1334, DOI 10.1152/ajpendo.00516.2001
   Li RW, 2006, LIFE SCI, V79, P365, DOI 10.1016/j.lfs.2006.01.023
   Liu QP, 2015, MOLECULES, V20, P21700, DOI 10.3390/molecules201219794
   Marycz K, 2018, STEM CELLS INT, V2018, DOI 10.1155/2018/5340756
   Marycz K, 2018, J CELL MOL MED, V22, P4771, DOI 10.1111/jcmm.13731
   Marycz K, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19010165
   Marycz K, 2017, MAR DRUGS, V15, DOI 10.3390/md15120385
   Marycz K, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/4710326
   Marycz K, 2016, J CELL MOL MED, V20, P2384, DOI 10.1111/jcmm.12932
   Meirelles LD, 2009, CYTOKINE GROWTH F R, V20, P419, DOI 10.1016/j.cytogfr.2009.10.002
   Meng Y, 2018, CELL TRANSPLANT, V27, P1495, DOI 10.1177/0963689718795692
   Minutolo A, 2012, CELL DEATH DIS, V3, DOI 10.1038/cddis.2012.97
   Mohammadi A, 2014, IRAN J BASIC MED SCI, V17, P263
   Muoio DM, 2008, NAT REV MOL CELL BIO, V9, P193, DOI 10.1038/nrm2327
   Nair SVG, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/637098
   Nash RJ, 2011, FUTURE MED CHEM, V3, P1513, DOI [10.4155/FMC.11.117, 10.4155/fmc.11.117]
   Nawrocka D, 2017, MAR DRUGS, V15, DOI 10.3390/md15080237
   Nejadhabibvash F., 2012, International Journal of Agriculture and Crop Sciences (IJACS), V4, P1300
   Ozcan L, 2012, ANNU REV MED, V63, P317, DOI 10.1146/annurev-med-043010-144749
   Pugazhenthi S, 2000, J BIOL CHEM, V275, P10761, DOI 10.1074/jbc.275.15.10761
   Rajgopal A, 2015, J MED FOOD, V18, P370, DOI 10.1089/jmf.2014.0096
   Ramos-Romero S, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201800373
   Rícny J, 2002, PHYSIOL RES, V51, P131, DOI 10.33549/physiolres.930094
   Roberts CK, 2013, COMPR PHYSIOL, V3, P1, DOI 10.1002/cphy.c110062
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Ron D, 2007, NAT REV MOL CELL BIO, V8, P519, DOI 10.1038/nrm2199
   Saben JL, 2016, CELL REP, V16, P1, DOI 10.1016/j.celrep.2016.05.065
   Saelens X, 2004, ONCOGENE, V23, P2861, DOI 10.1038/sj.onc.1207523
   Sakamuru S, 2012, PHYSIOL GENOMICS, V44, P495, DOI 10.1152/physiolgenomics.00161.2011
   Stofkova A, 2009, Endocr Regul, V43, P99
   Tadros EM, 2013, AM J VET RES, V74, P1010, DOI 10.2460/ajvr.74.7.1010
   Turban S, 2011, FEBS LETT, V585, P269, DOI 10.1016/j.febslet.2010.12.022
   Udalamaththa VL, 2016, STEM CELL RES THER, V7, DOI 10.1186/s13287-016-0366-4
   Wang LH, 2017, TZU CHI MED J, V29, P159, DOI 10.4103/tcmj.tcmj_60_17
   Yadav A, 2013, CLIN CHIM ACTA, V417, P80, DOI 10.1016/j.cca.2012.12.007
   Yang JL, 2018, J AGR FOOD CHEM, V66, P9418, DOI 10.1021/acs.jafc.8b03244
   Zang L, 2017, DIABETOL METAB SYNDR, V9, DOI 10.1186/s13098-017-0233-1
   Zhu JJ, 2014, EUR J PHARMACOL, V731, P65, DOI 10.1016/j.ejphar.2014.03.013
   Zierath JB, 1997, DIABETES, V46, P215, DOI 10.2337/diabetes.46.2.215
NR 66
TC 12
Z9 13
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1757-6512
J9 STEM CELL RES THER
JI Stem Cell Res. Ther.
PD JUN 18
PY 2019
VL 10
AR 178
DI 10.1186/s13287-019-1292-z
PG 20
WC Cell & Tissue Engineering; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA IE0YP
UT WOS:000472113100003
PM 31215461
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Merhi, Z
   Kandaraki, EA
   Diamanti-Kandarakis, E
AF Merhi, Zaher
   Kandaraki, Eleni A.
   Diamanti-Kandarakis, Evanthia
TI Implications and Future Perspectives of AGEs in PCOS Pathophysiology
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID GLYCATION END-PRODUCTS; POLYCYSTIC-OVARY-SYNDROME; ANTI-MULLERIAN
   HORMONE; DIETARY GLYCOTOXINS; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   GRANULOSA-CELLS; METABOLIC SYNDROME; FOLLICULAR-FLUID; RECEPTOR
AB Human, animal, and in vitro studies provide evidence that advanced glycation end-products (AGEs) may contribute to the pathogenesis of polycystic ovary syndrome (PCOS) and its metabolic and reproductive consequences. AGEs are able to induce, via activation of key intracellular signaling pathways, the generation of oxidative stress and proinflammatory cytokines, thus contributing to the adverse health impact of PCOS. This review presents the implications of AGEs in several disease pathophysiologies, including PCOS, as well as the cellular and systemic effects of AGEs on insulin resistance (IR), hyperandrogenemia, endoplasmic reticulum (ER) stress, hypoxia, and ovarian function. The gaps in our knowledge will serve as launching pad for future developments ranging from dietary and lifestyle changes to pharmaceutical interventions aiming at potential applications in women with PCOS.
C1 [Merhi, Zaher] NYU, Dept Obstet & Gynecol, Sch Med, New York, NY 10016 USA.
   [Merhi, Zaher] Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10467 USA.
   [Kandaraki, Eleni A.] St Bartholomews Hosp, Dept Endocrinol, London EC1A 7BE, England.
   [Diamanti-Kandarakis, Evanthia] Univ Athens, Sch Med, GR-11527 Athens, Greece.
   [Diamanti-Kandarakis, Evanthia] Hygeia Hosp, Endocrinol & Diabet Dept, Athens 15123, Greece.
C3 New York University; Montefiore Medical Center; Albert Einstein College
   of Medicine; Yeshiva University; University of London; Queen Mary
   University London; Athens Medical School; National & Kapodistrian
   University of Athens; Hygeia Hospital
RP Merhi, Z (corresponding author), NYU, Dept Obstet & Gynecol, Sch Med, New York, NY 10016 USA.; Merhi, Z (corresponding author), Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10467 USA.
EM zom00@hotmail.com
FU American Society for Reproductive Medicine (ASRM)
FX This work was funded by a grant from the American Society for
   Reproductive Medicine (ASRM) to Z.M.
CR ARAKI N, 1995, EUR J BIOCHEM, V230, P408, DOI 10.1111/j.1432-1033.1995.0408h.x
   Baranova A, 2011, ALIMENT PHARM THER, V33, P801, DOI 10.1111/j.1365-2036.2011.04579.x
   BROWNLEE M, 1995, ANNU REV MED, V46, P223, DOI 10.1146/annurev.med.46.1.223
   BROWNLEE M, 1986, SCIENCE, V232, P1629, DOI 10.1126/science.3487117
   Cai WJ, 2002, MOL MED, V8, P337, DOI 10.1007/BF03402014
   Carmina E, 1999, J CLIN ENDOCR METAB, V84, P1897, DOI 10.1210/jc.84.6.1897
   Carvajal R, 2013, HUM REPROD, V28, P2235, DOI 10.1093/humrep/det116
   Cassese A, 2008, J BIOL CHEM, V283, P36088, DOI 10.1074/jbc.M801698200
   Catteau-Jonard S, 2008, J CLIN ENDOCR METAB, V93, P4456, DOI 10.1210/jc.2008-1231
   Cerami C, 1997, P NATL ACAD SCI USA, V94, P13915, DOI 10.1073/pnas.94.25.13915
   Charikleia C, 2011, HORM-INT J ENDOCRINO, V10, P292, DOI 10.14310/horm.2002.1320
   Chatzigeorgiou A, 2013, J ENDOCRINOL, V218, P331, DOI 10.1530/JOE-13-0175
   Corti R, 2004, J THROMB THROMBOLYS, V17, P35, DOI 10.1023/B:THRO.0000036027.39353.70
   Cussons AJ, 2006, ATHEROSCLEROSIS, V185, P227, DOI 10.1016/j.atherosclerosis.2005.10.007
   Dewailly D, 2014, HUM REPROD UPDATE, V20, P370, DOI 10.1093/humupd/dmt062
   Diamanti-Kandarakis E, 2006, EUR J CLIN INVEST, V36, P691, DOI 10.1111/j.1365-2362.2006.01712.x
   Diamanti-Kandarakis E, 2005, CLIN ENDOCRINOL, V62, P37, DOI 10.1111/j.1365-2265.2004.02170.x
   Diamanti-Kandarakis E, 1999, J CLIN ENDOCR METAB, V84, P4006, DOI 10.1210/jc.84.11.4006
   Diamanti-Kandarakis E, 2008, CLIN ENDOCRINOL, V69, P634, DOI 10.1111/j.1365-2265.2008.03247.x
   Diamanti-Kandarakis Evanthia, 2008, Expert Reviews in Molecular Medicine, V10, P1, DOI 10.1017/S1462399408000598
   Diamanti-Kandarakis E, 2007, J MOL MED-JMM, V85, P1413, DOI 10.1007/s00109-007-0246-6
   Diamanti-Kandarakis E, 2007, HISTOCHEM CELL BIOL, V127, P581, DOI 10.1007/s00418-006-0265-3
   Diamanti-Kandarakis E, 2007, METABOLISM, V56, P129, DOI 10.1016/j.metabol.2006.09.006
   Diamanti-Kandarakis E, 2016, EXP BIOL MED, V241, P1438, DOI 10.1177/1535370215584937
   Diamanti-Kandarakis E, 2012, ENDOCR REV, V33, P981, DOI 10.1210/er.2011-1034
   Diamanti-Kandarakis E, 2009, EUR J ENDOCRINOL, V160, P847, DOI 10.1530/EJE-08-0510
   Diamanti-Kandarakis E, 2006, HUM REPROD, V21, P1426, DOI 10.1093/humrep/del003
   Dunaif A, 2001, AM J PHYSIOL-ENDOC M, V281, pE392, DOI 10.1152/ajpendo.2001.281.2.E392
   Durlinger ALL, 2002, ENDOCRINOLOGY, V143, P1076, DOI 10.1210/en.143.3.1076
   Fornes R, 2010, MOL MED, V16, P129, DOI 10.2119/molmed.2009.00118
   Förster A, 2005, ANN NY ACAD SCI, V1043, P474, DOI 10.1196/annals.1333.054
   Garg D, 2017, J ASSIST REPROD GEN, V34, P1507, DOI 10.1007/s10815-017-1011-6
   Grimm S, 2012, BIOCHEM J, V448, P127, DOI 10.1042/BJ20120298
   Guleria AK, 2014, GYNECOL ENDOCRINOL, V30, P26, DOI 10.3109/09513590.2013.831835
   He CJ, 1999, DIABETES, V48, P1308, DOI 10.2337/diabetes.48.6.1308
   Heijnen EMEW, 2006, HUM REPROD UPDATE, V12, P13, DOI 10.1093/humupd/dmi036
   Henmi H, 2001, BIOL REPROD, V64, P157
   Jinno M, 2011, HUM REPROD, V26, P604, DOI 10.1093/humrep/deq388
   Josso N, 2003, TRENDS ENDOCRIN MET, V14, P91, DOI 10.1016/S1043-2760(03)00005-5
   Josso N, 2001, MOL CELL ENDOCRINOL, V179, P25, DOI 10.1016/S0303-7207(01)00467-1
   Kandaraki E, 2012, MOL MED, V18, P1183, DOI 10.2119/molmed.2012.00293
   Kandaraki EA, 2018, EXP BIOL MED, V243, P29, DOI 10.1177/1535370217731288
   Karoli Ritu, 2012, Indian J Endocrinol Metab, V16, P1004, DOI 10.4103/2230-8210.103021
   Karuputhula NB, 2013, SYST BIOL REPROD MED, V59, P91, DOI 10.3109/19396368.2012.743197
   Kasper M, 2001, ARCH GERONTOL GERIAT, V32, P233, DOI 10.1016/S0167-4943(01)00103-0
   Kayampilly PP, 2009, ENDOCRINOLOGY, V150, P929, DOI 10.1210/en.2008-1032
   Lambert EA, 2015, CLIN ENDOCRINOL, V83, P812, DOI 10.1111/cen.12803
   Lander HM, 1997, J BIOL CHEM, V272, P17810, DOI 10.1074/jbc.272.28.17810
   Liao Y, 2017, REPROD BIOL ENDOCRIN, V15, DOI 10.1186/s12958-017-0227-8
   Mak W, 2009, SEMIN THROMB HEMOST, V35, P613, DOI 10.1055/s-0029-1242715
   Meghnani V, 2014, INT J BIOCHEM CELL B, V57, P54, DOI 10.1016/j.biocel.2014.10.001
   Merhi Z, 2016, FERTIL STERIL, V106, pE76, DOI 10.1016/j.fertnstert.2016.07.224
   Merhi Z, 2015, FERTIL STERIL, V104, pE106, DOI 10.1016/j.fertnstert.2015.07.325
   Miele C, 2003, J BIOL CHEM, V278, P47376, DOI 10.1074/jbc.M301088200
   Monden M, 2013, DIABETES, V62, P478, DOI 10.2337/db11-1116
   Nakajima K, 2000, J BIOL CHEM, V275, P20880, DOI 10.1074/jbc.M905410199
   Orio F, 2004, J CLIN ENDOCR METAB, V89, P4588, DOI 10.1210/jc.2003-031867
   Ott C, 2014, REDOX BIOL, V2, P411, DOI 10.1016/j.redox.2013.12.016
   Papachroni KK, 2010, J CELL MOL MED, V14, P2460, DOI 10.1111/j.1582-4934.2009.00841.x
   Papalou O, 2016, CURR PHARM DESIGN, V22, P2709, DOI 10.2174/1381612822666160216151852
   Park JH, 2016, INT J MED SCI, V13, P451, DOI 10.7150/ijms.15389
   Pellatt L, 2007, J CLIN ENDOCR METAB, V92, P240, DOI 10.1210/jc.2006-1582
   Pellatt L, 2010, REPRODUCTION, V139, P825, DOI 10.1530/REP-09-0415
   Peppa M, 2010, J BIOMED BIOTECHNOL, DOI 10.1155/2010/527850
   Pertynska-Marczewska M, 2015, METABOLISM, V64, P1564, DOI 10.1016/j.metabol.2015.08.010
   Piperi C, 2012, J CLIN ENDOCR METAB, V97, P2231, DOI 10.1210/jc.2011-3408
   Pullerits R, 2009, RHEUMATOLOGY, V48, P785, DOI 10.1093/rheumatology/kep079
   Rajendran S, 2009, ATHEROSCLEROSIS, V204, P509, DOI 10.1016/j.atherosclerosis.2008.09.010
   Ramasamy R, 2012, AMINO ACIDS, V42, P1151, DOI 10.1007/s00726-010-0773-2
   Raucci A, 2008, FASEB J, V22, P3716, DOI 10.1096/fj.08-109033
   Rizvi AA, 2009, AM J MED SCI, V338, P310, DOI 10.1097/MAJ.0b013e3181a4158c
   Rosas C, 2010, HUM REPROD, V25, P2870, DOI 10.1093/humrep/deq232
   Rutkowska AZ, 2016, CURR PHARM DESIGN, V22, P5558, DOI 10.2174/1381612822666160714094404
   Schmidt AM, 2015, VASC PHARMACOL, V72, P1, DOI 10.1016/j.vph.2015.06.011
   Sharma C, 2015, J FOOD SCI TECH MYS, V52, P7561, DOI 10.1007/s13197-015-1851-y
   Singh R, 2001, DIABETOLOGIA, V44, P129, DOI 10.1007/s001250051591
   Soman S, 2013, J CELL COMMUN SIGNAL, V7, P19, DOI 10.1007/s12079-012-0181-3
   Sparvero LJ, 2009, J TRANSL MED, V7, DOI 10.1186/1479-5876-7-17
   Sprung VS, 2013, CLIN ENDOCRINOL, V78, P438, DOI 10.1111/j.1365-2265.2012.04490.x
   Su YQ, 2002, ENDOCRINOLOGY, V143, P2221, DOI 10.1210/en.143.6.2221
   Tanaka N, 2000, J BIOL CHEM, V275, P25781, DOI 10.1074/jbc.M001235200
   Tantalaki E, 2014, HORM-INT J ENDOCRINO, V13, P65, DOI 10.1007/BF03401321
   Tatone C, 2013, FERTIL STERIL, V99, P12, DOI 10.1016/j.fertnstert.2012.11.029
   Teng HW, 2013, GYNECOL ENDOCRINOL, V29, P238, DOI 10.3109/09513590.2012.736553
   Thornalley Paul J., 2008, Drug Metabolism and Drug Interactions, V23, P125
   Unoki H, 2008, CURR PHARM DESIGN, V14, P987, DOI 10.2174/138161208784139747
   Uribarri J, 2005, ANN NY ACAD SCI, V1043, P461, DOI 10.1196/annals.1333.052
   Uribarri J, 2007, J GERONTOL A-BIOL, V62, P427, DOI 10.1093/gerona/62.4.427
   Vlassara H, 2002, J INTERN MED, V251, P87, DOI 10.1046/j.1365-2796.2002.00932.x
   Vlassara H, 2002, P NATL ACAD SCI USA, V99, P15596, DOI 10.1073/pnas.242407999
   Wang BJ, 2017, REPRODUCTION, V153, P285, DOI 10.1530/REP-16-0359
   Wang J, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000008183
   Wood JR, 2007, J CLIN ENDOCR METAB, V92, P705, DOI 10.1210/jc.2006-2123
   Yamagishi S, 2005, CURR DIABETES REV, V1, P93, DOI 10.2174/1573399052952631
   Yonekura H, 2003, BIOCHEM J, V370, P1097, DOI 10.1042/BJ20021371
   Zhai J, 2012, BIOL REPROD, V87, DOI 10.1095/biolreprod.112.099788
   Zhang L, 2008, J BIOL CHEM, V283, P35507, DOI 10.1074/jbc.M806948200
NR 97
TC 47
Z9 49
U1 0
U2 33
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD MAR
PY 2019
VL 30
IS 3
BP 150
EP 162
DI 10.1016/j.tem.2019.01.005
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HM0HR
UT WOS:000459128600003
PM 30712978
DA 2025-06-11
ER

PT J
AU Ndrepepa, G
   Colleran, R
   Kastrati, A
AF Ndrepepa, Gjin
   Colleran, Roisin
   Kastrati, Adnan
TI Gamma-glutamyl transferase and the risk of atherosclerosis and coronary
   heart disease
SO CLINICA CHIMICA ACTA
LA English
DT Review
DE Atherosclerosis; Coronary heart disease; Gamma-glutamyl transferase;
   Mortality
ID FATTY LIVER-DISEASE; CHRONIC KIDNEY-DISEASE; ELEVATION
   MYOCARDIAL-INFARCTION; HEPATIC INSULIN-RESISTANCE; YOUNG-ADULTS CARDIA;
   CARDIOVASCULAR-DISEASE; ALCOHOL-CONSUMPTION; OXIDATIVE STRESS; ARTERY
   CALCIFICATION; METABOLIC SYNDROME
AB Gamma-glutamyl transferase (GGT) is a ubiquitous cell surface enzyme that cleaves extracellular glutathione (G-SH) or other gamma-glutamyl compounds. GGT serves to increase the availability of amino acids, primarily cysteine, for intracellular G-SH synthesis and plays a crucial role in maintaining G-SH homeostasis and defense against oxidative stress in organisms. Measurement of circulating GGT activity is widely used for the diagnosis of liver and obstructive biliary diseases and as an indicator of alcohol consumption. Epidemiological studies suggest an association between elevated GGT activity level and a risk of incident coronary heart disease (CHD) or CHD-related mortality. Elevated GGT activity level is associated with a plethora of cardio-metabolic risk factors, including traditional cardiovascular risk factors, metabolic syndrome, systemic inflammation, oxidative stress burden and various comorbidities that incur a negative impact on patient risk profile and prognosis. Experimental studies and studies of human atherosclerotic plaques have revealed not only the presence of catalytically active GGT in atherosclerotic plaques, but also a correlation between GGT activity and indices of plaque instability, suggesting direct involvement in the pathophysiology of atherosclerosis and related clinical events via promotion of pro-oxidant reactions by the enzyme. However, it remains unknown whether GGT plays a direct role in the pathophysiology of atherosclerosis and CHD or is merely a correlate of coexisting cardiovascular risk factors. The exact molecular mechanisms of GGT participation in atherosclerosis or CHD and assessment of GGT-lowering therapies, as well as their impact on clinical outcomes, remain to be investigated in longitudinal studies.
C1 [Ndrepepa, Gjin; Colleran, Roisin; Kastrati, Adnan] Tech Univ Munich, Deutsch Herzzentrum Munchen, Dept Adult Cardiol, Munich, Germany.
   [Kastrati, Adnan] DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany.
C3 Technical University of Munich; German Heart Centre Munich; German
   Centre for Cardiovascular Research; Munich Heart Alliance
RP Ndrepepa, G (corresponding author), Deutsch Herzzentrum Munich, Lazarettstr 36, D-80636 Munich, Germany.
EM ndrepepa@dhm.mhn.de
RI , Kastrati/Y-2389-2019
OI Colleran, Roisin/0000-0002-9603-9502
CR Akpek M, 2012, ANGIOLOGY, V63, P579, DOI 10.1177/0003319711431880
   Aksakal E, 2012, ATHEROSCLEROSIS, V221, P596, DOI 10.1016/j.atherosclerosis.2012.01.044
   Ali SS, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0097-7
   [Anonymous], 2015, OXID MED CELL LONGEV
   Arinc H, 2013, UPSALA J MED SCI, V118, P228, DOI 10.3109/03009734.2013.814734
   Bell S, 2017, BMJ-BRIT MED J, V356, DOI 10.1136/bmj.j909
   BINKLEY F, 1948, J BIOL CHEM, V173, P411
   Bonnet F, 2011, DIABETES, V60, P1660, DOI 10.2337/db10-1806
   Bose T, 2009, EXP BIOL MED, V234, P1519, DOI 10.3181/0903-RM-115
   Breitling LP, 2010, ATHEROSCLEROSIS, V210, P649, DOI 10.1016/j.atherosclerosis.2009.12.037
   Brien SE, 2011, BMJ-BRIT MED J, V342, DOI 10.1136/bmj.d636
   BULLE F, 1990, HEPATOLOGY, V11, P545, DOI 10.1002/hep.1840110404
   Bulusu S, 2016, ANN CLIN BIOCHEM, V53, P312, DOI 10.1177/0004563215597010
   Carmiel-Haggai M, 2003, GASTROENTEROLOGY, V125, P1818, DOI 10.1053/j.gastro.2003.09.019
   Castellano I, 2013, MOL BIOL, VVIII, P1
   Celik O, 2014, CLIN CARDIOL, V37, P552, DOI 10.1002/clc.22307
   Chen J, 2017, JAMA CARDIOL, V2, P635, DOI 10.1001/jamacardio.2017.0363
   Cho YK, 2015, ATHEROSCLEROSIS, V243, P300, DOI 10.1016/j.atherosclerosis.2015.09.027
   Çiftçi Ö, 2013, CORONARY ARTERY DIS, V24, P201, DOI 10.1097/MCA.0b013e32835e5c86
   Collins JE, 1997, GENOME RES, V7, P522, DOI 10.1101/gr.7.5.522
   Demir B, 2012, KARDIOL POL, V70, P31
   DEMIROVIC J, 1993, CIRCULATION, V88, P2787, DOI 10.1161/01.CIR.88.6.2787
   Di Q, 2017, NEW ENGL J MED, V376, P2513, DOI 10.1056/NEJMoa1702747
   Dominici S, 2005, METHOD ENZYMOL, V401, P484, DOI 10.1016/S0076-6879(05)01029-3
   Dominici S, 2003, BIOFACTORS, V17, P187, DOI 10.1002/biof.5520170118
   Drozdz R, 1998, FREE RADICAL BIO MED, V25, P786, DOI 10.1016/S0891-5849(98)00127-0
   Du GL, 2013, PREV MED, V57, P31, DOI 10.1016/j.ypmed.2013.03.011
   Emdin M, 2002, STROKE, V33, P1163, DOI 10.1161/01.STR.0000012344.35312.13
   Emdin M, 2001, EUR HEART J, V22, P1802, DOI 10.1053/euhj.2001.2807
   Fargion S, 2014, WORLD J GASTROENTERO, V20, P13306, DOI 10.3748/wjg.v20.i37.13306
   FIGLEWICZ DA, 1993, GENOMICS, V17, P299, DOI 10.1006/geno.1993.1325
   Fornaciari I, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0088532
   Franzini M, 2008, ANAL BIOCHEM, V374, P1, DOI 10.1016/j.ab.2007.10.025
   Franzini M, 2013, CLIN CHIM ACTA, V417, P19, DOI 10.1016/j.cca.2012.12.002
   Franzini M, 2009, ATHEROSCLEROSIS, V202, P119, DOI 10.1016/j.atherosclerosis.2008.03.023
   Fraser A, 2007, ARTERIOSCL THROM VAS, V27, P2729, DOI 10.1161/ATVBAHA.107.152298
   GJERDE H, 1987, BRIT J ADDICT, V82, P1027
   Godsland IF, 2008, METABOLISM, V57, P1190, DOI 10.1016/j.metabol.2008.04.010
   HAMMOND JW, 1995, J INHERIT METAB DIS, V18, P82, DOI 10.1007/BF00711381
   HANES CS, 1952, BIOCHEM J, V51, P25, DOI 10.1042/bj0510025
   Hanigan MH, 2014, ADV CANCER RES, V122, P103, DOI 10.1016/B978-0-12-420117-0.00003-7
   HEISTERKAMP N, 1991, P NATL ACAD SCI USA, V88, P6303, DOI 10.1073/pnas.88.14.6303
   Heisterkamp N, 2008, HUM GENET, V123, P321, DOI 10.1007/s00439-008-0487-7
   Hietala J, 2005, ALCOHOL ALCOHOLISM, V40, P511, DOI 10.1093/alcalc/agh201
   HILL AB, 1965, P ROY SOC MED, V58, P295, DOI 10.1177/003591576505800503
   Hogg N, 1997, BIOCHEM J, V323, P477, DOI 10.1042/bj3230477
   Husain Kazim, 2015, World J Biol Chem, V6, P209, DOI 10.4331/wjbc.v6.i3.209
   HUSEBY NE, 1982, CLIN CHIM ACTA, V124, P113, DOI 10.1016/0009-8981(82)90325-4
   Janszky I, 2004, ATHEROSCLEROSIS, V176, P311, DOI 10.1016/j.atherosclerosis.2004.05.012
   Jiang SY, 2013, EXP CLIN CARDIOL, V18, P53
   Jung CH, 2011, CLIN ENDOCRINOL, V75, P328, DOI 10.1111/j.1365-2265.2011.04060.x
   Kaufman JD, 2016, LANCET, V388, P696, DOI 10.1016/S0140-6736(16)00378-0
   Kawamoto R, 2010, CARDIOVASC DIABETOL, V9, DOI 10.1186/1475-2840-9-87
   Kazemi-Shirazi L, 2007, CLIN CHEM, V53, P940, DOI 10.1373/clinchem.2006.081620
   Kengne AP, 2012, J HEPATOL, V57, P1083, DOI 10.1016/j.jhep.2012.06.034
   Korpilahti K, 1998, EUR HEART J, V19, P711, DOI 10.1053/euhj.1997.0869
   Kozakova M, 2012, HEPATOLOGY, V55, P1406, DOI 10.1002/hep.25555
   KRISTENSON H, 1981, AM J EPIDEMIOL, V114, P862, DOI 10.1093/oxfordjournals.aje.a113256
   Kunutsor SK, 2015, INT J CLIN PRACT, V69, P136, DOI 10.1111/ijcp.12507
   Kunutsor SK, 2016, LIVER INT, V36, P1723, DOI 10.1111/liv.13221
   Kunutsor SK, 2015, ATHEROSCLEROSIS, V238, P356, DOI 10.1016/j.atherosclerosis.2014.12.045
   Kunutsor SK, 2014, ATHEROSCLEROSIS, V236, P7, DOI 10.1016/j.atherosclerosis.2014.06.006
   Lee DH, 2005, ATHEROSCLEROSIS, V178, P327, DOI 10.1016/j.atherosclerosis.2004.08.027
   Lee DH, 2004, FREE RADICAL RES, V38, P535, DOI 10.1080/10715760410001694026
   Lee DH, 2004, AM J CLIN NUTR, V79, P600
   Lee DH, 2003, CLIN CHEM, V49, P1358, DOI 10.1373/49.8.1358
   Lee DH, 2003, DIABETOLOGIA, V46, P359, DOI 10.1007/s00125-003-1036-5
   Lee DS, 2007, ARTERIOSCL THROM VAS, V27, P127, DOI 10.1161/01.ATV.0000251993.20372.40
   Lee DH, 2009, FREE RADICAL RES, V43, P533, DOI 10.1080/10715760902893324
   LEGGETT BA, 1990, CLIN CHEM, V36, P1350
   Li G, 2014, BMC CARDIOVASC DISOR, V14, DOI 10.1186/1471-2261-14-145
   Lieberman MW, 1996, P NATL ACAD SCI USA, V93, P7923, DOI 10.1073/pnas.93.15.7923
   Lim JS, 2007, CLIN CHEM, V53, P1092, DOI 10.1373/clinchem.2006.079814
   Lim JS, 2004, FREE RADICAL BIO MED, V37, P1018, DOI 10.1016/j.freeradbiomed.2004.06.032
   Lim S, 2015, INT J CARDIOL, V201, P408, DOI 10.1016/j.ijcard.2015.08.107
   MARNELA KM, 1985, J NEUROCHEM, V44, P752, DOI 10.1111/j.1471-4159.1985.tb12878.x
   Mayatepek E, 2004, J LIPID RES, V45, P900, DOI 10.1194/jlr.M300462-JLR200
   McClelland RL, 2008, AM J CLIN NUTR, V88, P1593, DOI 10.3945/ajcn.2008.26420
   MEISTER A, 1973, SCIENCE, V180, P33, DOI 10.1126/science.180.4081.33
   Meneghini R, 1997, FREE RADICAL BIO MED, V23, P783, DOI 10.1016/S0891-5849(97)00016-6
   NAKAJIMA T, 1994, AM J CLIN NUTR, V60, P87, DOI 10.1093/ajcn/60.1.87
   Ndrepepa G, 2016, ANN TRANSL MED, V4, DOI 10.21037/atm.2016.12.27
   Ndrepepa G, 2016, AM J CARDIOL, V117, P1427, DOI 10.1016/j.amjcard.2016.02.004
   Ndrepepa G, 2016, CLIN CHIM ACTA, V452, P155, DOI 10.1016/j.cca.2015.11.013
   Nigro J, 2006, ENDOCR REV, V27, P242, DOI 10.1210/er.2005-0007
   NILSSEN O, 1990, AM J EPIDEMIOL, V132, P318, DOI 10.1093/oxfordjournals.aje.a115661
   NYSTROM E, 1988, ACTA MED SCAND, V224, P79
   Oksuz F, 2015, AM J CARDIOL, V116, P711, DOI 10.1016/j.amjcard.2015.05.042
   Ozcan F, 2012, J INVEST MED, V60, P1186, DOI 10.2310/JIM.0b013e31826d9043
   Paolicchi A, 1999, J INVEST MED, V47, P151
   Paolicchi A, 2004, CIRCULATION, V109, P1440, DOI 10.1161/01.CIR.0000120558.41356.E6
   Paschos P, 2012, WORLD J HEPATOL, V4, P327, DOI 10.4254/wjh.v4.i12.327
   PAWLAK A, 1988, J BIOL CHEM, V263, P9913
   Pucci A, 2014, ATHEROSCLEROSIS, V237, P307, DOI 10.1016/j.atherosclerosis.2014.09.028
   Puukka K, 2006, AM J CLIN NUTR, V83, P1351, DOI 10.1093/ajcn/83.6.1351
   RAJPERTDEMEYTS E, 1988, P NATL ACAD SCI USA, V85, P8840, DOI 10.1073/pnas.85.23.8840
   ROLLASON JG, 1972, CLIN CHIM ACTA, V39, P75, DOI 10.1016/0009-8981(72)90301-4
   Ruttmann E, 2005, CIRCULATION, V112, P2130, DOI 10.1161/CIRCULATIONAHA.105.552547
   Ryu S, 2007, CLIN CHEM, V53, P71, DOI 10.1373/clinchem.2006.078980
   Saely CH, 2008, CLIN CHIM ACTA, V397, P82, DOI 10.1016/j.cca.2008.07.024
   Schiffrin EL, 2007, CIRCULATION, V116, P85, DOI 10.1161/CIRCULATIONAHA.106.678342
   Schroeder EF, 1935, J BIOL CHEM, V110, P181
   Sen N, 2009, TURK KARDIYOL DERN A, V37, P168
   Sesti G, 2013, NUTR METAB CARDIOVAS, V23, P1182, DOI 10.1016/j.numecd.2013.01.006
   STARK AA, 1993, CARCINOGENESIS, V14, P183, DOI 10.1093/carcin/14.2.183
   Stepanova M, 2012, CLIN GASTROENTEROL H, V10, P646, DOI 10.1016/j.cgh.2011.12.039
   Stocker R, 2004, PHYSIOL REV, V84, P1381, DOI 10.1152/physrev.00047.2003
   Stocker R, 2005, J THROMB HAEMOST, V3, P1825, DOI 10.1111/j.1538-7836.2005.01370.x
   Stojakovic T, 2010, ATHEROSCLEROSIS, V208, P564, DOI 10.1016/j.atherosclerosis.2009.07.026
   Strasak AM, 2008, ARTERIOSCL THROM VAS, V28, P1857, DOI 10.1161/ATVBAHA.108.170597
   Sung KC, 2015, CLIN CHEM, V61, P1173, DOI 10.1373/clinchem.2015.240424
   Targher G, 2008, J AM SOC NEPHROL, V19, P1564, DOI 10.1681/ASN.2007101155
   Targher G, 2015, ARTERIOSCL THROM VAS, V35, P2290, DOI 10.1161/ATVBAHA.115.305235
   Terzyan SS, 2015, J BIOL CHEM, V290, P17576, DOI 10.1074/jbc.M115.659680
   Toshikuni N, 2015, J ATHEROSCLER THROMB, V22, P1051, DOI 10.5551/jat.28274
   Ulus T, 2007, ATHEROSCLEROSIS, V195, P348, DOI 10.1016/j.atherosclerosis.2006.09.025
   Vasan RS, 2006, CIRCULATION, V113, P2335, DOI 10.1161/CIRCULATIONAHA.104.482570
   Vliegenthart R, 2004, ARCH INTERN MED, V164, P2355, DOI 10.1001/archinte.164.21.2355
   WANNAMETHEE G, 1995, AM J EPIDEMIOL, V142, P699, DOI 10.1093/oxfordjournals.aje.a117699
   Wei D, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/741731
   West MB, 2013, ANTIOXID REDOX SIGN, V19, P1877, DOI 10.1089/ars.2012.4997
   West MB, 2013, J BIOL CHEM, V288, P31902, DOI 10.1074/jbc.M113.498139
   Whitfield JB, 2002, CLIN CHEM, V48, P1426
   Whitfield JB, 2001, CRIT REV CL LAB SCI, V38, P263, DOI 10.1080/20014091084227
   Wickham S, 2011, ANAL BIOCHEM, V414, P208, DOI 10.1016/j.ab.2011.03.026
   Yagmur J, 2010, ACTA CARDIOL, V65, P515, DOI 10.1080/AC.65.5.2056237
   Zhang HQ, 2009, AM J RESP CELL MOL, V41, P509, DOI 10.1165/rcmb.2009-0169TR
NR 127
TC 124
Z9 130
U1 1
U2 27
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD JAN
PY 2018
VL 476
BP 130
EP 138
DI 10.1016/j.cca.2017.11.026
PG 9
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA FT2WN
UT WOS:000423006800021
PM 29175647
DA 2025-06-11
ER

PT J
AU Palanisamy, N
   Viswanathan, P
   Ravichandran, MK
   Anuradha, CV
AF Palanisamy, Nallasamy
   Viswanathan, Periyasamy
   Ravichandran, Mambakkam Katchapeswaran
   Anuradha, Carani Venkataraman
TI Renoprotective and blood pressure-lowering effect of dietary soy protein
   via protein kinase C βII inhibition in a rat model of metabolic syndrome
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE blood pressure; casein; protein kinase C beta II; fructose; soy protein;
   kinins; nitric oxide
ID ANGIOTENSIN-CONVERTING-ENZYME; FRUCTOSE-INDUCED HYPERTENSION; URINARY
   ALBUMIN EXCRETION; INSULIN-RESISTANCE; NITRIC-OXIDE;
   DIABETIC-NEPHROPATHY; GLOMERULAR INJURY; OXIDATIVE STRESS; LIPID
   PROFILE; L-CARNITINE
AB We studied whether substitution of soy protein for casein (an improve insulin sensitivity, lower blood pressure (BP), and inhibit protein kinase C beta II (PKC beta II) activation in kidney in an acquired model of metabolic syndrome. Adult male rats were fed 4 different diets: (i) starch (60%) and casein (200/v) (CCD), (ii) fructose (60%) and casein (20%) (FCD), (iii) fructose (60%) and soy protein (20%) (FSD), and (iv) starch (60%) and soy protein (20%) (CSD). Renal function parameters, BP, pressor mechanisms, PKC beta II expression, oxidative stress, and renal histology were evaluated after 60 days. FCD rats displayed insulin resistance and significant changes in body weight, kidney weight, urine volume, plasma and urine electrolytes accompanied by significant changes in renal function parameters compared with CCD rats. Elevated BP, plasma angiotensin-converting enzyme (ACE) activity, renal oxidative stress, and reduced nitrite (NO) and kallikrein activity were observed. Western blot analysis revealed enhanced renal expression of membrane-associated PKC beta II in the FCD group. Histology showed fatty infiltration and thickening of glomeruli while urinary protein profile revealed a 5-fold increase in albumin. Substitution of soy protein for casein improved insulin sensitivity, lowered BP and PKC beta II activation and restored renal function. Antioxidant action, inhibitory effect on ACE and PKC beta II activation, and increased availability of kinins and NO could be contributing mechanisms for the benefits of dietary soy protein.
C1 [Palanisamy, Nallasamy; Anuradha, Carani Venkataraman] Annamalai Univ, Fac Sci, Dept Biochem & Biotechnol, Annamalainagar 608002, Tamil Nadu, India.
   [Viswanathan, Periyasamy] Annamalai Univ, Dept Pathol, Fac Med, Rajah Muthaih Med Coll, Annamalainagar 608002, Tamil Nadu, India.
   [Ravichandran, Mambakkam Katchapeswaran] Annamalai Univ, Fac Sci, Dept Stat, Annamalainagar 608002, Tamil Nadu, India.
C3 Annamalai University; Annamalai University; Annamalai University
RP Anuradha, CV (corresponding author), Annamalai Univ, Fac Sci, Dept Biochem & Biotechnol, Annamalainagar 608002, Tamil Nadu, India.
EM cvaradha@hotmail.com
RI Venkatraman, Anuradha/U-8717-2019; Nallasamy, Palanisamy/AAH-7727-2021
OI NALLASAMY, PALANISAMY/0000-0001-8962-2487
FU Indian Council of Medical Research (ICMR), New Delhi
FX The financial support in the form of a Senior Research Fellowship to Mr.
   N. Palanisamy from the Indian Council of Medical Research (ICMR), New
   Delhi, is gratefully acknowledged. The authors thank Mr. M. Manikam,
   Managing Director, Sakthi Suvars Pvt. Ltd., a division of Sakthi Soya
   Pvt. Ltd., Coimbatore, India, for providing soy protein concentrate.
CR ARAKI E, 1991, J BIOL CHEM, V266, P3944
   Azadbakht L, 2003, EUR J CLIN NUTR, V57, P1292, DOI 10.1038/sj.ejcn.1601688
   Bhanot S, 1999, AM J PHYSIOL-ENDOC M, V277, pE299, DOI 10.1152/ajpendo.1999.277.2.E299
   Catena C, 2003, KIDNEY INT, V64, P2163, DOI 10.1046/j.1523-1755.2003.00313.x
   Chen ST, 2006, BRIT J NUTR, V96, P435, DOI 10.1079/BJN20061751
   DEFRONZO RA, 1991, DIABETES CARE, V14, P173, DOI 10.2337/diacare.14.3.173
   El Midaoui A, 2008, CAN J PHYSIOL PHARM, V86, P752, DOI 10.1139/Y08-090
   ELLMAN GL, 1959, ARCH BIOCHEM BIOPHYS, V82, P70, DOI 10.1016/0003-9861(59)90090-6
   Galipeau D, 2001, HYPERTENSION, V38, P872, DOI 10.1161/hyp.38.4.872
   Ganz MB, 1997, EXP NEPHROL, V5, P225
   Girillo P, 2006, J AM SOC NEPHROL, V17, pS165, DOI 10.1681/ASN.2006080909
   Gutt M, 2000, DIABETES RES CLIN PR, V47, P177, DOI 10.1016/S0168-8227(99)00116-3
   HALLER H, 1995, KIDNEY INT, V47, P1057, DOI 10.1038/ki.1995.152
   Higashiura KS, 2000, AM J HYPERTENS, V13, P290, DOI 10.1016/S0895-7061(99)00174-0
   HOLMQUIST B, 1979, ANAL BIOCHEM, V95, P540, DOI 10.1016/0003-2697(79)90769-3
   HWANG IS, 1987, HYPERTENSION, V10, P512, DOI 10.1161/01.HYP.10.5.512
   IKENAGA H, 1993, KIDNEY INT, V43, P205, DOI 10.1038/ki.1993.33
   Jiang JH, 2005, MOL CELL BIOCHEM, V280, P69, DOI 10.1007/s11010-005-8053-2
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   Kelly DJ, 2003, DIABETES, V52, P512, DOI 10.2337/diabetes.52.2.512
   KONTESSIS P, 1990, KIDNEY INT, V38, P136, DOI 10.1038/ki.1990.178
   Koya D, 1998, DIABETES, V47, P859, DOI 10.2337/diabetes.47.6.859
   Lavigne C, 2000, AM J PHYSIOL-ENDOC M, V278, pE491, DOI 10.1152/ajpendo.2000.278.3.E491
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   Martin DS, 2001, AM J PHYSIOL-REG I, V281, pR553, DOI 10.1152/ajpregu.2001.281.2.R553
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   NARITA I, 1995, P NATL ACAD SCI USA, V92, P4552, DOI 10.1073/pnas.92.10.4552
   NIEHAUS WG, 1968, EUR J BIOCHEM, V6, P126, DOI 10.1111/j.1432-1033.1968.tb00428.x
   Nishimoto Y, 2002, HYPERTENSION, V40, P190, DOI 10.1161/01.HYP.0000024267.71656.0D
   Ohtake K, 2007, NITRIC OXIDE-BIOL CH, V17, P75, DOI 10.1016/j.niox.2007.06.004
   Oshida Y, 2000, HORM METAB RES, V32, P339, DOI 10.1055/s-2007-978649
   Palanisamy N, 2008, RENAL FAILURE, V30, P645, DOI 10.1080/08860220802134532
   Parvanova AI, 2006, DIABETES, V55, P1456, DOI 10.2337/db05-1484
   Pfaff IL, 2002, KIDNEY BLOOD PRESS R, V25, P329, DOI 10.1159/000066789
   Pfaff IL, 1999, J AM SOC NEPHROL, V10, P1861
   Rajasekar P, 2008, DIABETES OBES METAB, V10, P171, DOI 10.1111/j.1463-1326.2007.00825.x
   Rajasekar P, 2007, CLIN EXP HYPERTENS, V29, P517, DOI 10.1080/10641960701743998
   Reungjui S, 2007, J AM SOC NEPHROL, V18, P2724, DOI 10.1681/ASN.2007040416
   Rock Edmond, 1995, Magnesium Research, V8, P237
   Sánchez-Lozada LG, 2008, AM J PHYSIOL-RENAL, V294, pF710, DOI 10.1152/ajprenal.00454.2007
   Sanchez-Lozada LG, 2007, AM J PHYSIOL-RENAL, V292, pF423, DOI 10.1152/ajprenal.00124.2006
   Teixeira SR, 2004, J NUTR, V134, P1874, DOI 10.1093/jn/134.8.1874
   Tovar AR, 2002, J NUTR, V132, P2562, DOI 10.1093/jn/132.9.2562
   Trautschold I, 1974, METHOD ENZYMAT AN, V2, P1031
   VARLEY H, 2004, PRACTICAL CLIN BIOCH, V10, P168
   Vasdev S, 2002, MOL CELL BIOCHEM, V241, P107, DOI 10.1023/A:1020835229591
   Vasdev S, 2004, CLIN BIOCHEM, V37, P1, DOI 10.1016/j.clinbiochem.2003.09.003
   Yang HY, 2008, HYPERTENS RES, V31, P957, DOI 10.1291/hypres.31.957
   Yuan J, 2007, J RENIN-ANGIO-ALDO S, V8, P118, DOI 10.3317/jraas.2007.014
NR 49
TC 13
Z9 16
U1 0
U2 6
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD JAN
PY 2010
VL 88
IS 1
BP 28
EP 37
DI 10.1139/Y09-110
PG 10
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 565FE
UT WOS:000275273800005
PM 20130736
DA 2025-06-11
ER

PT J
AU Sharkey, D
   Gardner, DS
   Fainberg, HP
   Sébert, S
   Bos, P
   Wilson, V
   Bell, R
   Symonds, ME
   Budge, H
AF Sharkey, Don
   Gardner, David S.
   Fainberg, Hernan P.
   Sebert, Sylvain
   Bos, Petra
   Wilson, Vicky
   Bell, Rhonda
   Symonds, Michael E.
   Budge, Helen
TI Maternal nutrient restriction during pregnancy differentially alters the
   unfolded protein response in adipose and renal tissue of obese juvenile
   offspring
SO FASEB JOURNAL
LA English
DT Article
DE endoplasmic reticulum; inflammation; fetus; metabolic syndrome
ID ENDOPLASMIC-RETICULUM STRESS; METABOLIC SYNDROME; DEVELOPMENTAL ORIGINS;
   MACROPHAGE INFILTRATION; GLUCOSE-HOMEOSTASIS; ADIPOCYTE DEATH;
   KIDNEY-DISEASE; ER STRESS; EXPRESSION; DIET
AB Maternal diet during pregnancy can program an offspring's risk of disease in later life. Obesity adversely alters renal and adipose tissue function, resulting in chronic kidney disease and insulin resistance, respectively, the latter associated with dysregulation of the unfolded protein response (UPR). In view of the current obesity epidemic, we explored the combined effects of in utero early-to midgestational nutrient restriction and postnatal obesity on the UPR in ovine juvenile offspring. Nutrient restriction was coincident with fetal kidney development but prior to exponential adipose tissue deposition. Nutrient restricted (NR) and normal diet (control) offspring were exposed to an obesogenic environment throughout adolescence, resulting in similar degrees of juvenile obesity. NR offspring showed enhanced adipose tissue dysregulation characterized by activation of the UPR, perturbed insulin signaling, and marked inflammation, as demonstrated by increased abundance of crownlike structures and proinflammatory genes. Conversely, in renal tissue NR offspring had marked attenuation of cellular stress and inflammation evident as reduced activation of the UPR, down-regulation of proinflammatory genes, and less histological damage. In conclusion, obesity-related activation of the UPR can be determined by the in utero nutritional environment, demonstrating organ-specific effects dependent on the developmental phase targeted within the fetus.-Sharkey, D., Gardner, D. S., Fainberg, H. P., Sebert, S., Bos, P., Wilson, V., Bell, R., Symonds, M. E., Budge, H. Maternal nutrient restriction during pregnancy differentially alters the unfolded protein response in adipose and renal tissue of obese juvenile offspring. FASEB J. 23, 1314-1324 (2009)
C1 [Sharkey, Don; Fainberg, Hernan P.; Sebert, Sylvain; Bos, Petra; Wilson, Vicky; Symonds, Michael E.; Budge, Helen] Univ Nottingham, Inst Clin Res, Ctr Reprod & Early Life, Nottingham NG7 2RD, England.
   [Gardner, David S.] Univ Nottingham, Sch Vet Med & Sci, Loughborough, England.
   [Bell, Rhonda] Univ Alberta, Alberta Inst Human Nutr, Edmonton, AB, Canada.
C3 University of Nottingham; University of Nottingham; University of
   Alberta
RP Symonds, ME (corresponding author), Univ Hosp, Sch Clin Sci, Div Human Dev, E Floor E Block,Derby Rd, Nottingham NG7 2UH, England.
EM michael.symonds@nottingham.ac.uk
RI Fainberg, Hernan/A-2449-2012; Gardner, David S/A-7484-2010
OI Fainberg, Hernan Pablo/0000-0001-9330-9047; Fainberg,
   Hernan/0000-0003-3742-3165; Symonds, Michael/0000-0001-9649-8963;
   Sebert, Sylvain/0000-0001-6681-6983; Bell, Rhonda
   C./0000-0002-4298-9641; Sharkey, Don/0000-0002-4989-8697; Gardner, David
   S/0000-0002-6490-2412
FU British Heart Foundation [FS/05/098/19942, BS/03/01]; European Union
   Sixth Framework for Research and Technical Development of the European
   Community [FOOD-CT-2005-007036]
FX This work was support by a British Heart Foundation clinical fellowship
   (D. S., FS/05/098/19942) and lectureship (D. S. G., BS/03/01) and the
   European Union Sixth Framework for Research and Technical Development of
   the European Community, the Early Nutrition Programming Project
   (FOOD-CT-2005-007036).
CR Alderman G., 1996, Energy and Protein Requirements of Ruminants
   Bedard K, 2004, BASIC CLIN PHARMACOL, V94, P124, DOI 10.1111/j.1742-7843.2004.pto940305.x
   Boden G, 2008, DIABETES, V57, P2438, DOI 10.2337/db08-0604
   Bogacka I, 2005, DIABETES, V54, P1392, DOI 10.2337/diabetes.54.5.1392
   Cameron AJ, 2004, ENDOCRIN METAB CLIN, V33, P351, DOI 10.1016/j.ecl.2004.03.005
   Cinti S, 2005, J LIPID RES, V46, P2347, DOI 10.1194/jlr.M500294-JLR200
   Dunphy J, 2001, VET IMMUNOL IMMUNOP, V82, P153, DOI 10.1016/S0165-2427(01)00356-7
   Eckersall PD, 2008, BMC VET RES, V4, DOI 10.1186/1746-6148-4-1
   Gluckman PD, 2008, NEW ENGL J MED, V359, P61, DOI 10.1056/NEJMra0708473
   Gopalakrishnan GS, 2005, BRIT J NUTR, V94, P938, DOI 10.1079/BJN20051559
   Gregor MF, 2007, J LIPID RES, V48, P1905, DOI 10.1194/jlr.R700007-JLR200
   Hall JE, 1999, ANN NY ACAD SCI, V892, P91, DOI 10.1111/j.1749-6632.1999.tb07788.x
   Harman-Boehm I, 2007, J CLIN ENDOCR METAB, V92, P2240, DOI 10.1210/jc.2006-1811
   Henegar JR, 2001, J AM SOC NEPHROL, V12, P1211, DOI 10.1681/ASN.V1261211
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Inagi R, 2005, KIDNEY INT, V68, P2639, DOI 10.1111/j.1523-1755.2005.00736.x
   Inagi R, 2008, J AM SOC NEPHROL, V19, P915, DOI 10.1681/ASN.2007070745
   Ingelfinger JR, 2005, J AM SOC NEPHROL, V16, P2533, DOI 10.1681/ASN.2005060622
   Johann AM, 2007, FASEB J, V21, P2704, DOI 10.1096/fj.06-7815com
   Kaaman M, 2007, DIABETOLOGIA, V50, P2526, DOI 10.1007/s00125-007-0818-6
   Kanda H, 2006, J CLIN INVEST, V116, P1494, DOI 10.1172/JCI26498
   Kelishadi R, 2007, CLIN CHEM, V53, P456, DOI 10.1373/clinchem.2006.073668
   KELLY T, 2008, INT J OBES IN PRESS
   Kern PA, 2001, AM J PHYSIOL-ENDOC M, V280, pE745
   Koh EH, 2007, DIABETES, V56, P2973, DOI 10.2337/db07-0510
   Lomax MA, 2007, ENDOCRINOLOGY, V148, P461, DOI 10.1210/en.2006-0918
   Lumeng CN, 2007, DIABETES, V56, P16, DOI 10.2337/db06-1076
   McMillen IC, 2005, PHYSIOL REV, V85, P571, DOI 10.1152/physrev.00053.2003
   Moritz KM, 2003, BIOESSAYS, V25, P212, DOI 10.1002/bies.10240
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Ozanne SE, 2007, NAT CLIN PRACT ENDOC, V3, P539, DOI 10.1038/ncpendmet0531
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Pan Y, 2008, J AM DIET ASSOC, V108, P276, DOI 10.1016/j.jada.2007.10.049
   Pfaffl MW, 2001, NUCLEIC ACIDS RES, V29, DOI 10.1093/nar/29.9.e45
   Plisov SY, 2000, GENESIS, V27, P22, DOI 10.1002/1526-968X(200005)27:1<22::AID-GENE40>3.0.CO;2-V
   SEBERT SP, 2008, ENDOCRINOLO IN PRESS
   Serra A, 2008, KIDNEY INT, V73, P947, DOI 10.1038/sj.ki.5002796
   Spalding KL, 2008, NATURE, V453, P783, DOI 10.1038/nature06902
   Strissel KJ, 2007, DIABETES, V56, P2910, DOI 10.2337/db07-0767
   Symonds ME, 2003, J ENDOCRINOL, V179, P293, DOI 10.1677/joe.0.1790293
   Taylor PD, 2005, AM J PHYSIOL-REG I, V288, pR134, DOI 10.1152/ajpregu.00355.2004
   Weisberg SP, 2006, J CLIN INVEST, V116, P115, DOI 10.1172/JCI24335
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Weiss R, 2004, NEW ENGL J MED, V350, P2362, DOI 10.1056/NEJMoa031049
   Westerbacka J, 2008, AM J PHYSIOL-ENDOC M, V294, pE841, DOI 10.1152/ajpendo.00653.2006
   Williams PJ, 2007, KIDNEY INT, V72, P279, DOI 10.1038/sj.ki.5002276
   Wood CE, 2005, AM J PHYSIOL-REG I, V289, pR613, DOI 10.1152/ajpregu.00722.2004
   Zandi-Nejad K, 2006, HYPERTENSION, V47, P502, DOI 10.1161/01.HYP.0000198544.09909.1a
   Zhao LH, 2006, CURR OPIN CELL BIOL, V18, P444, DOI 10.1016/j.ceb.2006.06.005
NR 49
TC 38
Z9 42
U1 0
U2 7
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD MAY
PY 2009
VL 23
IS 5
BP 1314
EP 1324
DI 10.1096/fj.08-114330
PG 11
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 453ZP
UT WOS:000266651700008
PM 19103646
DA 2025-06-11
ER

PT J
AU Ebenezer, PJ
   Mariappan, N
   Elks, CM
   Haque, M
   Soltani, Z
   Reisin, E
   Francis, J
AF Ebenezer, Philip J.
   Mariappan, Nithya
   Elks, Carrie M.
   Haque, Masudul
   Soltani, Zohreh
   Reisin, Efrain
   Francis, Joseph
TI Effects of pyrrolidine dithiocarbamate on high-fat diet-induced
   metabolic and renal alterations in rats
SO LIFE SCIENCES
LA English
DT Article
DE Metabolic syndrome; Oxidative stress; Kidney; Diet
ID FACTOR-KAPPA-B; MITOCHONDRIAL OXIDATIVE STRESS; OBESE ZUCKER RAT;
   DIABETIC-NEPHROPATHY; INSULIN SENSITIVITY; HEART-FAILURE;
   PARAVENTRICULAR NUCLEUS; PROTEIN; ALPHA; HYPERTENSION
AB Aims: We investigated the effects of the nuclear factor kappa B (NF kappa B) blocker pyrrolidine dithiocarbamate (PDTC) on high-fat diet (HFD)-induced metabolic and renal alterations in obese and lean Zucker rats (OZR and LZR, respectively).
   Main methods: Rats were fed a HFD resembling the typical "Western" diet or a regular diet (RD) and allowed free access to tap water or tap water containing PDTC (150 mg/kg body weight) for 10 weeks: rats were then sacrificed. Total ROS production rates were measured using electron paramagnetic resonance spectroscopy, and superoxide production was measured with lucigenin assay. Blood, plasma, and urine were analyzed. Semi-quantitative reverse transcriptase-polymerase chain reaction and electrophoretic mobility shift assay were conducted to assess NF kappa B mRNA levels and DNA binding activities, respectively: immunofluorescence was performed to assess protein levels.
   Key findings: OZR-HFD rats exhibited significantly higher levels of total renal cortical reactive oxygen species production, plasma lipids, insulin, C-reactive protein, blood urea nitrogen, creatinine, and urinary albumin excretion than all other groups (p < 0.05); these changes were accompanied by a significant decrease in plasma high density lipoprotein levels (p < 0.05). Gene expression levels of desmin, cytokine and oxidative stress genes were significantly higher in the renal cortical tissues of OZR-HFD; NF kappa B p65 DNA binding activity was also significantly higher in these animals. PDTC attenuated these changes.
   Significance: Our data suggest that NF kappa B blockade may prove beneficial in treating the nephropathy often associated with metabolic syndrome. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Ebenezer, Philip J.; Mariappan, Nithya; Elks, Carrie M.; Haque, Masudul; Francis, Joseph] Louisiana State Univ, Sch Vet Med, Dept Comparat Biomed Sci, Baton Rouge, LA 70803 USA.
   [Soltani, Zohreh; Reisin, Efrain] Louisiana State Univ, Hlth Sci Ctr, Sect Nephrol & Hypertens, New Orleans, LA 70112 USA.
C3 Louisiana State University System; Louisiana State University; Louisiana
   State University School of Veterinary Medicine; Louisiana State
   University System; Louisiana State University Health Sciences Center New
   Orleans
RP Francis, J (corresponding author), Louisiana State Univ, Sch Vet Med, Dept Comparat Biomed Sci, Baton Rouge, LA 70803 USA.
EM jfrancis@lsu.edu
RI Francis, Joseph/I-4984-2012; Elks, Carrie/N-1961-2017
OI Francis, Joseph/0000-0002-9502-4579
FU National Heart Lung and Blood Institute [RO1 HL080544-01]
FX These studies were supported by a grant from the National Heart Lung and
   Blood Institute (RO1 HL080544-01) for Dr. Joseph Francis. We sincerely
   thank Dr. Olga Borkhsenious for conducting TEM studies, and Ms. Sherry
   Ring for her assistance with tissue sectioning.
CR Bae JH, 2001, ATHEROSCLEROSIS, V155, P517, DOI 10.1016/S0021-9150(00)00601-8
   Banday AA, 2005, DIABETES, V54, P2219, DOI 10.2337/diabetes.54.7.2219
   Blackwell TS, 1997, AM J RESP CELL MOL, V17, P3, DOI 10.1165/ajrcmb.17.1.f132
   Ceriello A, 2008, DIABETES CARE, V31, pS181, DOI 10.2337/dc08-s245
   Chander PN, 2004, J AM SOC NEPHROL, V15, P2391, DOI 10.1097/01.ASN.0000135971.88164.2C
   Christman JW, 1998, INTENS CARE MED, V24, P1131, DOI 10.1007/s001340050735
   Christman JW, 2000, BRAIN PATHOL, V10, P153
   Coimbra TM, 2000, KIDNEY INT, V57, P167, DOI 10.1046/j.1523-1755.2000.00836.x
   Cornelussen RNM, 2001, J MOL CELL CARDIOL, V33, P1447, DOI 10.1006/jmcc.2001.1406
   Coughlan MT, 2007, ENDOCRINOLOGY, V148, P886, DOI 10.1210/en.2006-1300
   DANIS RP, 1993, INVEST OPHTH VIS SCI, V34, P2367
   de Mello VDF, 2008, DIABETOLOGIA, V51, P2060, DOI 10.1007/s00125-008-1132-7
   EBENEZER PJ, 2009, DIET INDUCED RENAL C
   Elks CM, 2009, AM J PHYSIOL-RENAL, V296, pF298, DOI 10.1152/ajprenal.90628.2008
   Fortuño A, 2006, DIABETES, V55, P209, DOI 10.2337/diabetes.55.1.209
   Friedman EA, 2007, NEPHROL DIAL TRANSPL, V22, P681, DOI 10.1093/ndt/gfl735
   Gassler N, 2001, KIDNEY INT, V60, P106, DOI 10.1046/j.1523-1755.2001.00777.x
   Giugliano D, 2006, J AM COLL CARDIOL, V48, P677, DOI 10.1016/j.jacc.2006.03.052
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Guggilam A, 2007, AM J PHYSIOL-HEART C, V293, pH599, DOI 10.1152/ajpheart.00286.2007
   Guijarro C, 2001, KIDNEY INT, V59, P415, DOI 10.1046/j.1523-1755.2001.059002415.x
   Inoguchi T, 2000, DIABETES, V49, P1939, DOI 10.2337/diabetes.49.11.1939
   Isomaa B, 2003, LIFE SCI, V73, P2395, DOI 10.1016/S0024-3205(03)00646-5
   KASISKE BL, 1985, J LAB CLIN MED, V106, P598
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Khaleduzzaman M, 2007, J VIROL, V81, P12307, DOI 10.1128/JVI.01002-07
   Kidambi S, 2007, HYPERTENSION, V49, P704, DOI 10.1161/01.HYP.0000253258.36141.c7
   Kris-Etherton P, 2001, CIRCULATION, V103, P1823, DOI 10.1161/01.CIR.103.13.1823
   Lavaud S, 1996, J AM SOC NEPHROL, V7, P2604
   LI Y, 2008, J BIOL CHEM
   Li YL, 2007, CARDIOVASC RES, V75, P546, DOI 10.1016/j.cardiores.2007.04.006
   Mansouri RM, 2008, CIRC RES, V103, P450, DOI 10.1161/CIRCRESAHA.108.179861
   Mariappan N, 2007, AM J PHYSIOL-HEART C, V293, pH2726, DOI 10.1152/ajpheart.00376.2007
   Meyer C, 2004, AM J PHYSIOL-ENDOC M, V287, pE1049, DOI 10.1152/ajpendo.00041.2004
   Mori S, 1996, DIABETES RES CLIN PR, V33, P145, DOI 10.1016/0168-8227(96)01290-9
   Morishima A, 2003, J BIOL CHEM, V278, P38188, DOI 10.1074/jbc.M306336200
   Mundy AL, 2007, CARDIOVASC RES, V73, P368, DOI 10.1016/j.cardiores.2006.11.019
   Nishikawa T, 2000, NATURE, V404, P787, DOI 10.1038/35008121
   Picchi A, 2006, CIRC RES, V99, P69, DOI 10.1161/01.RES.0000229685.37402.80
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Riccardi G, 2004, CLIN NUTR, V23, P447, DOI 10.1016/j.clnu.2004.02.006
   Ridker PM, 2004, CIRCULATION, V109, P2818, DOI 10.1161/01.CIR.0000132467.45278.59
   Ritz E, 1996, AM J KIDNEY DIS, V27, P167, DOI 10.1016/S0272-6386(96)90538-7
   Ruan XZ, 2008, AM J PHYSIOL-RENAL, V294, pF1032, DOI 10.1152/ajprenal.00152.2007
   Russo I, 2008, ENDOCRINOLOGY, V149, P1480, DOI 10.1210/en.2007-0920
   Schena FP, 2005, J AM SOC NEPHROL, V16, pS30, DOI 10.1681/ASN.2004110970
   Yamazaki Y, 2008, LIFE SCI, V82, P290, DOI 10.1016/j.lfs.2007.11.016
   Yu Y, 2007, HYPERTENSION, V49, P511, DOI 10.1161/01.HYP.0000257356.20527.c5
NR 48
TC 22
Z9 26
U1 0
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD AUG 26
PY 2009
VL 85
IS 9-10
BP 357
EP 364
DI 10.1016/j.lfs.2009.06.019
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 491RI
UT WOS:000269596500003
PM 19631668
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Behl, T
   Sehgal, A
   Bala, R
   Chadha, S
AF Behl, Tapan
   Sehgal, Aayush
   Bala, Rajni
   Chadha, Swati
TI Understanding the molecular mechanisms and role of autophagy in obesity
SO MOLECULAR BIOLOGY REPORTS
LA English
DT Review
DE Obesity; Autophagy; Metabolic syndrome; Cardiac autophagy; Insulin
   resistance
ID ADIPOSE-TISSUE AUTOPHAGY; ENDOPLASMIC-RETICULUM STRESS;
   INSULIN-RESISTANCE; BECLIN 1; CARDIAC-HYPERTROPHY; CELL-DEATH; ER
   STRESS; HEALTH; FAT; ACTIVATION
AB Vital for growth, proliferation, subsistence, and thermogenesis, autophagy is the biological cascade, which confers defence against aging and various pathologies. Current research has demonstrated de novo activity of autophagy in stimulation of biological events. There exists a significant association between autophagy activation and obesity, encompassing expansion of adipocytes which facilitates beta cell activity. The main objective of the manuscript is to enumerate intrinsic role of autophagy in obesity and associated complications. The peer review articles published till date were searched using medical databases like PubMed and MEDLINE for research, primarily in English language. Obesity is characterized by adipocytic hypertrophy and hyperplasia, which leads to imbalance of lipid absorption, free fatty acid release, and mitochondrial activity. Detailed evaluation of obesity progression is necessary for its treatment and related comorbidities. Data collected in regard to etiological sustaining of obesity, has revealed hypothesized energy misbalance and neuro-humoral dysfunction, which is stimulated by autophagy. Autophagy regulates chief salvaging events for protein clustering, excessive triglycerides, and impaired mitochondria which is accompanied by oxidative and genotoxic stress in mammals. Autophagy is a homeostatic event, which regulates biological process by eliminating lethal cells and reprocessing physiological constituents, comprising of proteins and fat. Unquestionably, autophagy impairment is involved in metabolic syndromes, like obesity. According to an individual's metabolic outline, autophagy activation is essential for metabolism and activity of the adipose tissue and to retard metabolic syndrome i.e. obesity. The manuscript summarizes the perception of current knowledge on autophagy stimulation and its effect on the obesity.
C1 [Behl, Tapan; Sehgal, Aayush; Bala, Rajni; Chadha, Swati] Chitkara Univ, Chitkara Coll Pharm, Chandigarh, Punjab, India.
C3 Chitkara University, Punjab
RP Behl, T (corresponding author), Chitkara Univ, Chitkara Coll Pharm, Chandigarh, Punjab, India.
EM tapanbehl31@gmail.com
RI Behl, Tapan/W-3523-2019
OI bala, rajni/0000-0002-6960-3403
CR Abdellatif M, 2020, PROG MOL BIOL TRANSL, V172, P87, DOI 10.1016/bs.pmbts.2020.04.022
   Abu Salman L, 2020, CURR CARDIOL REP, V22, DOI 10.1007/s11886-020-1257-y
   Afshin A, 2017, NEW ENGL J MED, V377, P13, DOI 10.1056/NEJMoa1614362
   Aoyagi K, 2016, DIABETES, V65, P1648, DOI 10.2337/db15-1207
   Ashkenazi A, 2017, NATURE, V545, P108, DOI 10.1038/nature22078
   Barros JAS, 2020, TRENDS PLANT SCI, V25, P1141, DOI 10.1016/j.tplants.2020.05.004
   Bartolomeo R, 2017, J CLIN INVEST, V127, P3717, DOI 10.1172/JCI94130
   Ben-Sahra I, 2016, SCIENCE, V351, P728, DOI 10.1126/science.aad0489
   Bento CF, 2016, ANNU REV BIOCHEM, V85, P685, DOI 10.1146/annurev-biochem-060815-014556
   Bhattacharya B, 2014, BRIT J PHARMACOL, V171, P3255, DOI 10.1111/bph.12668
   Birnbaum A, 2021, FRONT AGING NEUROSCI, V12, DOI 10.3389/fnagi.2020.567861
   Boström P, 2012, NATURE, V481, P463, DOI 10.1038/nature10777
   Burscha W, 2008, TOXICOLOGY, V254, P147, DOI 10.1016/j.tox.2008.07.048
   Castañeda D, 2019, OBESITY, V27, P1050, DOI 10.1002/oby.22455
   Cheng J W., 2014, PLoS One, V9
   Chesmore K, 2018, HUM GENET, V137, P39, DOI 10.1007/s00439-017-1854-z
   Choi JA, 2020, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.03147
   Chrostowska M, 2013, BEST PRACT RES CL EN, V27, P147, DOI 10.1016/j.beem.2013.01.004
   Chu KY, 2015, DIABETOLOGIA, V58, P2074, DOI 10.1007/s00125-015-3665-x
   Clemente-Postigo M, 2020, METABOLITES, V10, DOI 10.3390/metabo10050179
   Cnop M, 2005, DIABETES, V54, pS97, DOI 10.2337/diabetes.54.suppl_2.S97
   Codogno P, 2010, CELL METAB, V11, P449, DOI 10.1016/j.cmet.2010.05.006
   Di Malta C, 2017, SCIENCE, V356, P1188, DOI 10.1126/science.aag2553
   Dikic I, 2018, NAT REV MOL CELL BIO, V19, P349, DOI 10.1038/s41580-018-0003-4
   Formica V, ENDOCRINE METABOLIC
   Fujitani Y, 2010, AM J PHYSIOL-CELL PH, V299, pC1, DOI 10.1152/ajpcell.00084.2010
   Galluzzi L, 2014, CELL, V159, P1263, DOI 10.1016/j.cell.2014.11.006
   Gonzalez CD, 2011, AUTOPHAGY, V7, P2, DOI 10.4161/auto.7.1.13044
   Grundy SM, 2016, TRENDS CARDIOVAS MED, V26, P364, DOI 10.1016/j.tcm.2015.10.004
   Gu X, 2017, SCIENCE, V358, P813, DOI 10.1126/science.aao3265
   Hadi NR, 2017, INT J CARDIOL, V230, P269, DOI 10.1016/j.ijcard.2016.12.127
   Hariharan N, 2010, CIRC RES, V107, P1470, DOI 10.1161/CIRCRESAHA.110.227371
   He CC, 2013, CELL, V154, P1085, DOI 10.1016/j.cell.2013.07.035
   He H, 2014, CELL DEATH DIS, V5, DOI 10.1038/cddis.2013.533
   He Q, 2016, BIOCHEM BIOPH RES CO, V476, P196, DOI 10.1016/j.bbrc.2016.05.086
   Hill SM, 2019, CELL DEATH DIFFER, V26, P617, DOI 10.1038/s41418-018-0254-9
   Hirota M, 2020, PANCREAS, V49, P493, DOI 10.1097/MPA.0000000000001519
   Holczer M, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-75030-8
   Hubler MJ, 2016, J NUTR BIOCHEM, V34, P1, DOI 10.1016/j.jnutbio.2015.11.002
   Jaishy B, 2015, J LIPID RES, V56, P546, DOI 10.1194/jlr.M055152
   Jeckel KM, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-92
   Johansen T, 2020, J MOL BIOL, V432, P80, DOI 10.1016/j.jmb.2019.07.016
   Jung HS, 2008, CELL METAB, V8, P318, DOI 10.1016/j.cmet.2008.08.013
   Kaushik S, 2012, EMBO REP, V13, P258, DOI 10.1038/embor.2011.260
   Kaushik S, 2011, CELL METAB, V14, P173, DOI 10.1016/j.cmet.2011.06.008
   Kim KH, 2013, NAT MED, V19, P83, DOI 10.1038/nm.3014
   Kosacka J, 2015, MOL CELL ENDOCRINOL, V409, P21, DOI 10.1016/j.mce.2015.03.015
   Kouroumalis E, 2021, WORLD J HEPATOL, V13, DOI 10.4254/wjh.v13.i1.6
   Kovsan J, 2011, J CLIN ENDOCR METAB, V96, pE268, DOI 10.1210/jc.2010-1681
   Kwak HJ, 2016, CELL SIGNAL, V28, P788, DOI 10.1016/j.cellsig.2016.03.015
   Lee HY, 2016, AUTOPHAGY, V12, P1390, DOI 10.1080/15548627.2016.1184799
   Levine B, 2019, CELL, V176, P11, DOI 10.1016/j.cell.2018.09.048
   Levine B, 2015, J CLIN INVEST, V125, P14, DOI 10.1172/JCI73938
   Lim YM, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms5934
   Lin CW, 2013, J HEPATOL, V58, P993, DOI 10.1016/j.jhep.2013.01.011
   Liu GY, 2020, NAT REV MOL CELL BIO, V21, P183, DOI 10.1038/s41580-019-0199-y
   Lu S, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.567238
   Maejima Y, 2016, J MOL CELL CARDIOL, V95, P19, DOI 10.1016/j.yjmcc.2015.10.032
   Maïano C, 2016, OBES REV, V17, P599, DOI 10.1111/obr.12408
   Mao YQ, 2015, CELL PHYSIOL BIOCHEM, V37, P563, DOI 10.1159/000430377
   Marcelin G, 2020, AUTOPHAGY, V16, P2156, DOI 10.1080/15548627.2020.1717129
   Martens S, 2020, CELL DISCOV, V6, DOI 10.1038/s41421-020-0155-1
   Matsuura N, 2015, INT J CARDIOL, V179, P360, DOI 10.1016/j.ijcard.2014.11.099
   Meng QY, 2011, J BIOL CHEM, V286, P32324, DOI 10.1074/jbc.M111.254417
   Menikdiwela KR, 2020, CELL DEATH DIS, V11, DOI 10.1038/s41419-020-2275-9
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   Mozaffarian D, 2015, CIRCULATION, V131, pE29, DOI 10.1161/CIR.0000000000000152
   Nalliah CJ, 2016, EUR HEART J, V37, P1565, DOI 10.1093/eurheartj/ehv486
   Nishida K, 2016, J MOL CELL CARDIOL, V95, P11, DOI 10.1016/j.yjmcc.2015.12.003
   Nuñez CE, 2013, INT J OBESITY, V37, P1473, DOI 10.1038/ijo.2013.27
   Osborn O, 2010, CELL METAB, V12, P553, DOI 10.1016/j.cmet.2010.11.017
   Öst A, 2010, MOL MED, V16, P235, DOI 10.2119/molmed.2010.00023
   Pagano AF, 2014, MED SCI SPORT EXER, V46, P1314, DOI 10.1249/MSS.0000000000000237
   Papácková Z, 2014, PHYSIOL RES, V63, P409, DOI 10.33549/physiolres.932684
   Pietrocola F, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10010102
   Prieur X, 2011, DIABETES, V60, P797, DOI 10.2337/db10-0705
   Quan W, 2012, DIABETOLOGIA, V55, P392, DOI 10.1007/s00125-011-2350-y
   Rabar S, 2014, BMJ-BRIT MED J, V349, DOI 10.1136/bmj.g4356
   Ren SY, 2015, BBA-MOL BASIS DIS, V1852, P225, DOI 10.1016/j.bbadis.2014.04.029
   Rubinsztein DC, 2012, EMBO REP, V13, P173, DOI 10.1038/embor.2012.5
   Saxton RA, 2017, CELL, V168, P960, DOI [10.1016/j.cell.2017.02.004, 10.1016/j.cell.2017.03.035]
   Schiavi A, 2014, EXP GERONTOL, V56, P147, DOI 10.1016/j.exger.2014.02.015
   Schirone L, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/3920195
   Schroeder K, 2021, OBES REV, V22, DOI 10.1111/obr.13204
   Sciarretta S, 2014, HIGH BLOOD PRESS CAR, V21, P21, DOI 10.1007/s40292-013-0029-9
   Sekizkardes H, 2020, J CLIN INVEST, V130, P3592, DOI 10.1172/JCI135431
   Shen TT, 2019, FOOD CHEM TOXICOL, V131, DOI 10.1016/j.fct.2019.05.035
   Slutsky N, 2016, INT J OBESITY, V40, P912, DOI 10.1038/ijo.2016.5
   Soussi H, 2016, AUTOPHAGY, V12, P588, DOI 10.1080/15548627.2015.1106667
   Sung Joong Kyung, 2010, Korean Circ J, V40, P55, DOI 10.4070/kcj.2010.40.2.55
   Takahara T, 2020, J BIOMED SCI, V27, DOI 10.1186/s12929-020-00679-2
   Tanner MA, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21228507
   Tao T, 2020, ADV EXP MED BIOL, V1207, P445, DOI 10.1007/978-981-15-4272-5_32
   Thapalia BA, 2016, AM J TRANSL RES, V8, P3251
   Uchinaka A, 2017, PHARMACOL RES PERSPE, V5, DOI 10.1002/prp2.331
   Unsöld B, 2015, OBESITY, V23, P90, DOI 10.1002/oby.20888
   Wang Z, 2015, METABOLISM, V64, P917, DOI 10.1016/j.metabol.2015.04.010
   Winter JN, 2011, AM J PHYSIOL-CELL PH, V300, pC1172, DOI 10.1152/ajpcell.00504.2010
   Wondmkun YT, 2020, DIABET METAB SYND OB, V13, P3611, DOI 10.2147/DMSO.S275898
   Woo Y, 2017, ONCOL LETT, V13, P3579, DOI 10.3892/ol.2017.5872
   World Health Organization (WHO), Obesity and overweight
   Yang C, 2020, TRENDS GENET, V36, P676, DOI 10.1016/j.tig.2020.06.013
   Yang L, 2010, CELL METAB, V11, P467, DOI 10.1016/j.cmet.2010.04.005
   Yang Y, 2020, CELL DEATH DIFFER, V27, P858, DOI 10.1038/s41418-019-0480-9
   Ye JP, 2013, FRONT MED-PRC, V7, P14, DOI 10.1007/s11684-013-0262-6
   Yin JJ, 2012, AUTOPHAGY, V8, P158, DOI 10.4161/auto.8.2.18807
   Yu JT, 2014, NEUROBIOL AGING, V35, DOI [10.1016/j.neurobiolaging.2013.11.019, 10.1016/j.neurobiolaging.2013.10.075]
   Zhang J, 2020, THERANOSTICS, V10, P8315, DOI 10.7150/thno.45922
   Zhang J, 2012, CIRC RES, V110, pE29, DOI 10.1161/CIRCRESAHA.111.255950
   Zhang YP, 2016, PROG MOL BIOL TRANSL, V140, P185, DOI 10.1016/bs.pmbts.2016.02.003
   Zhang YM, 2018, NAT REV ENDOCRINOL, V14, P356, DOI 10.1038/s41574-018-0009-1
   Zheng J, 2021, PHARM BIOL, V59, P183, DOI 10.1080/13880209.2021.1878238
   Zhu HX, 2015, CURR CARDIOL REV, V11, P229, DOI 10.2174/1573403X10666141106104606
   Zuo ZC, 2020, CURR OPIN STRUC BIOL, V62, P166, DOI 10.1016/j.sbi.2020.01.013
NR 114
TC 9
Z9 9
U1 0
U2 10
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-4851
EI 1573-4978
J9 MOL BIOL REP
JI Mol. Biol. Rep.
PD MAR
PY 2021
VL 48
IS 3
BP 2881
EP 2895
DI 10.1007/s11033-021-06298-w
EA APR 2021
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA RQ2VW
UT WOS:000636166700002
PM 33797660
DA 2025-06-11
ER

PT J
AU Vesterdal, LK
   Danielsen, PH
   Folkmann, JK
   Jespersen, LF
   Aguilar-Pelaez, K
   Roursgaard, M
   Loft, S
   Moller, P
AF Vesterdal, Lise K.
   Danielsen, Pernille H.
   Folkmann, Janne K.
   Jespersen, Line F.
   Aguilar-Pelaez, Karin
   Roursgaard, Martin
   Loft, Steffen
   Moller, Peter
TI Accumulation of lipids and oxidatively damaged DNA in hepatocytes
   exposed to particles
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Comet assay; DNA damage; Inflammation; Nanoparticles; Oxidative stress;
   Steatosis
ID FATTY LIVER-DISEASE; ADHESION MOLECULE EXPRESSION; INSOLUBLE IRIDIUM
   PARTICLES; DIESEL EXHAUST PARTICLES; INSULIN-RESISTANCE; CARBON-BLACK;
   HEPATIC STEATOSIS; AMBIENT AIR; WOOD SMOKE; IN-VITRO
AB Exposure to particles has been suggested to generate hepatosteatosis by oxidative stress mechanisms. We investigated lipid accumulation in cultured human hepatocytes (HepG2) and rat liver after exposure to four different carbon-based particles. HepG2 cells were exposed to particles for 3 h and subsequently incubated for another 18 h to manifest lipid accumulation. In an animal model of metabolic syndrome we investigated the association between intake of carbon black (CB, 14 nm) particles and hepatic lipid accumulation, inflammation and gene expression of Srebp-1, Fasn and Scd-1 involved in lipid synthesis. There was a concentration-dependent increase in intracellular lipid content after exposure to CB in HepG2 cells, which was only observed after co-exposure to oleic/palmitic acid. Similar results were observed in HepG2 cells after exposure to diesel exhaust particles, fullerenes C-60 or pristine single-walled carbon nanotubes. All four types of particles also generated oxidatively damaged DNA, assessed as formamidopyrimidine DNA glycosylase (FPG) sensitive sites, in HepG2 cells after 3 h exposure. The animal model of metabolic syndrome showed increased lipid load in the liver after one oral exposure to 6.4 mg/kg of CB in lean Zucker rats. This was not associated with increased iNOS staining in the liver, indicating that the oral CB exposure was associated with hepatic steatosis rather than steatohepatitis. The lipid accumulation did not seem to be related to increased lipogenesis because there were unaltered gene expression levels in both the HepG2 cells and rat livers. Collectively, exposure to particles is associated with oxidative stress and steatosis in hepatocytes. (C) 2013 Published by Elsevier Inc.
C1 [Vesterdal, Lise K.; Danielsen, Pernille H.; Folkmann, Janne K.; Jespersen, Line F.; Aguilar-Pelaez, Karin; Roursgaard, Martin; Loft, Steffen; Moller, Peter] Univ Copenhagen, Environm Hlth Sect, Dept Publ Hlth, DK-1014 Copenhagen K, Denmark.
C3 University of Copenhagen
RP Moller, P (corresponding author), Univ Copenhagen, Environm Hlth Sect, Dept Publ Hlth, Oster Farimagsgade 5A, DK-1014 Copenhagen K, Denmark.
EM pemo@sund.ku.dk
RI Vesterdal, Lars/D-5227-2011; Roursgaard, Martin/D-7320-2016
OI Roursgaard, Martin/0000-0002-7206-0032; Loft,
   Steffen/0000-0001-9552-8518; Danielsen, Pernille
   Hogh/0000-0001-7212-7818
FU Center for Pharmaceutical Nanomedicine and Nanotoxicology; Lundbeck
   Foundation 'Center for Biomembranes in Nanomedicine'
FX The study was funded by grants from the Center for Pharmaceutical
   Nanomedicine and Nanotoxicology and the Lundbeck Foundation 'Center for
   Biomembranes in Nanomedicine'.
CR Amacher DE, 2011, EXPERT OPIN DRUG MET, V7, P949, DOI 10.1517/17425255.2011.577740
   Araujo JA, 2008, CIRC RES, V102, P589, DOI 10.1161/CIRCRESAHA.107.164970
   Araya J, 2004, CLIN SCI, V106, P635, DOI 10.1042/CS20030326
   Bhatia LS, 2012, EUR HEART J, V33, P1190, DOI 10.1093/eurheartj/ehr453
   Carr KE, 2012, PROG HISTOCHEM CYTO, V46, P185, DOI 10.1016/j.proghi.2011.11.001
   Collins A, 1997, ENVIRON MOL MUTAGEN, V30, P139, DOI 10.1002/(SICI)1098-2280(1997)30:2<139::AID-EM6>3.0.CO;2-I
   Cui W, 2010, AM J TRANSL RES, V2, P95
   Danielsen PH, 2008, MUTAT RES-FUND MOL M, V637, P49, DOI 10.1016/j.mrfmmm.2007.06.011
   Danielsen PH, 2011, CHEM RES TOXICOL, V24, P168, DOI 10.1021/tx100407m
   Danielsen PH, 2010, TOXICOL SCI, V118, P574, DOI 10.1093/toxsci/kfq290
   Danielsen PH, 2009, MUTAT RES-GEN TOX EN, V674, P116, DOI 10.1016/j.mrgentox.2008.10.014
   Danielsen PH, 2008, PART FIBRE TOXICOL, V5, DOI 10.1186/1743-8977-5-6
   Demetriou CA, 2012, OCCUP ENVIRON MED, V69, P619, DOI 10.1136/oemed-2011-100566
   den Boer M, 2004, ARTERIOSCL THROM VAS, V24, P644, DOI 10.1161/01.ATV.0000116217.57583.6e
   EFSA Panel on food additives and nutrition sources aaded to food (ANS), 2013, EFSA J, V10, P1292, DOI DOI 10.2903/J.EFSA2012.2592
   ESKELSON CD, 1987, ENVIRON RES, V44, P260, DOI 10.1016/S0013-9351(87)80235-9
   Folkmann JK, 2009, ENVIRON HEALTH PERSP, V117, P703, DOI 10.1289/ehp.11922
   Folkmann JK, 2012, TOXICOL SCI, V129, P98, DOI 10.1093/toxsci/kfs180
   Forchhammer L, 2012, TOXICOL LETT, V209, P121, DOI 10.1016/j.toxlet.2011.12.003
   Forchhammer L, 2010, MUTAGENESIS, V25, P113, DOI 10.1093/mutage/gep048
   Frikke-Schmidt H, 2011, TOXICOL LETT, V203, P181, DOI 10.1016/j.toxlet.2011.03.011
   Fujimura H, 2009, J APPL TOXICOL, V29, P356, DOI 10.1002/jat.1420
   Gómez-Lechón MJ, 2007, CHEM-BIOL INTERACT, V165, P106, DOI 10.1016/j.cbi.2006.11.004
   Hemmingsen JG, 2011, ENVIRON SCI TECHNOL, V45, P8545, DOI 10.1021/es200956p
   Jacobsen NR, 2008, MUTAT RES-FUND MOL M, V641, P54, DOI 10.1016/j.mrfmmm.2008.03.001
   Jacobsen NR, 2008, ENVIRON MOL MUTAGEN, V49, P476, DOI 10.1002/em.20406
   Jacobsen NR, 2007, ENVIRON MOL MUTAGEN, V48, P451, DOI 10.1002/em.20300
   Jantzen K, 2012, MUTAGENESIS, V27, P693, DOI 10.1093/mutage/ges035
   Johnston H, 2013, CRIT REV TOXICOL, V43, P1, DOI 10.3109/10408444.2012.738187
   Karpe F, 2011, DIABETES, V60, P2441, DOI 10.2337/db11-0425
   Khandoga A, 2004, CIRCULATION, V109, P1320, DOI 10.1161/01.CIR.0000118524.62298.E8
   Kreyling WG, 2002, J TOXICOL ENV HEAL A, V65, P1513, DOI 10.1080/00984100290071649
   Kuehl PJ, 2012, INHAL TOXICOL, V24, P27, DOI 10.3109/08958378.2011.632787
   Leach CL, 2012, ANN ALLERG ASTHMA IM, V108, P195, DOI 10.1016/j.anai.2012.01.010
   Matsunami T, 2010, INT J CLIN EXP PATHO, V3, P472
   McMillian MK, 2001, IN VITRO MOL TOXICOL, V14, P177, DOI 10.1089/109793301753407948
   Mendez-Gonzalez J., 2011, BIOCHIM BIOPHYS ACTA, V1811, P186
   Moller P, 2012, CURR MOL MED, V12, P732, DOI 10.2174/156652412800792624
   Moller P, 2013, CRIT REV TOXICOL, V43, P96, DOI 10.3109/10408444.2012.756456
   Moller P, 2012, FREE RADICAL RES, V46, P541, DOI 10.3109/10715762.2011.644241
   Moller P, 2011, CRIT REV TOXICOL, V41, P339, DOI 10.3109/10408444.2010.533152
   Moller P, 2010, ENVIRON HEALTH PERSP, V118, P1126, DOI 10.1289/ehp.0901725
   Moller P, 2010, FREE RADICAL RES, V44, P1, DOI 10.3109/10715760903300691
   Negre-Salvayre A, 2010, FREE RADICAL RES, V44, P1125, DOI 10.3109/10715762.2010.498478
   Neuschwander-Tetri BA, 2010, HEPATOLOGY, V52, P774, DOI 10.1002/hep.23719
   Preiss D, 2008, CLIN SCI, V115, P141, DOI 10.1042/CS20070402
   Raubenheimer PJ, 2006, DIABETES, V55, P2015, DOI 10.2337/db06-0097
   Rinella ME, 2008, J LIPID RES, V49, P1068, DOI 10.1194/jlr.M800042-JLR200
   Sekiya M, 2008, BIOCHEM BIOPH RES CO, V375, P602, DOI 10.1016/j.bbrc.2008.08.068
   Semmler M, 2004, INHAL TOXICOL, V16, P453, DOI 10.1080/08958370490439650
   Sturm R, 2007, COMPUT BIOL MED, V37, P680, DOI 10.1016/j.compbiomed.2006.06.004
   Su K, 2012, J BIOL CHEM, V287, P28564, DOI 10.1074/jbc.M112.360081
   Tan HH, 2009, J IMMUNOTOXICOL, V6, P266, DOI 10.1080/15476910903241704
   Tilg H, 2010, HEPATOLOGY, V52, P1836, DOI 10.1002/hep.24001
   Tilg H, 2008, TRENDS ENDOCRIN MET, V19, P371, DOI 10.1016/j.tem.2008.08.005
   Tomaru M, 2007, INT J MOL MED, V19, P17
   Vendemiale G, 2001, HEPATOLOGY, V33, P808, DOI 10.1053/jhep.2001.23060
   Vesterdal LK, 2012, TOXICOL LETT, V214, P19, DOI 10.1016/j.toxlet.2012.07.022
   Xu XH, 2011, TOXICOL SCI, V124, P88, DOI 10.1093/toxsci/kfr211
   Xu ZB, 2011, PART FIBRE TOXICOL, V8, DOI 10.1186/1743-8977-8-20
   Zhao L, 2011, J GASTROEN HEPATOL, V26, P875, DOI 10.1111/j.1440-1746.2010.06560.x
NR 61
TC 59
Z9 62
U1 1
U2 43
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD JAN 15
PY 2014
VL 274
IS 2
BP 350
EP 360
DI 10.1016/j.taap.2013.10.001
PG 11
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA 298OE
UT WOS:000330333000018
PM 24121055
DA 2025-06-11
ER

PT J
AU Geetha, R
   Yogalakshmi, B
   Sreeja, S
   Bhavani, K
   Anuradha, CV
AF Geetha, Rajagopalan
   Yogalakshmi, Baskaran
   Sreeja, S.
   Bhavani, K.
   Anuradha, Carani Venkatraman
TI Troxerutin suppresses lipid abnormalities in the heart of
   high-fat-high-fructose diet-fed mice
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE High-fat-high-fructose diet; Heart lipids; Oxidative stress; Troxerutin
ID INSULIN SENSITIVITY; METABOLIC SYNDROME; OXIDATIVE STRESS; INDUCED
   HYPERTENSION; ACID; ALPHA; EXPRESSION; LIVER; RATS; TRANSPORTERS
AB The reversal effect of troxerutin (TX) on obesity, insulin resistance, lipid accumulation, oxidative damage, and hypertension induced in the high-fat-high-fructose diet (HFFD)-fed mice model of metabolic syndrome was investigated. Adult male Mus musculus mice of body weight 25-30 g were fed either control diet or HFFD. Each group was divided into two and treated or untreated with TX (150 mg/kg bw, p.o.) from the 16th day. Assays were done in plasma and heart after 30 and 60 days of the experimental period. Significant increase in the levels of glucose and insulin, blood pressure (BP), and oxidative stress were observed after 30 days of HFFD feeding as compared to control. Animals fed HFFD for 60 days developed more severe changes in the above parameters compared to those fed for 30 days. Hearts of HFFD-fed mice registered downregulation of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor gamma coactivator-1 alpha, carnitine palmitoyl transferse-1b and AMP-activated protein kinase; and upregulation of cluster of differentiation 36, fatty acid-binding protein-1, and sterol regulatory element-binding protein-1c after 60 days. TX administration restricted obesity (as seen by Lee's index); improved whole body insulin sensitivity; reduced BP, lipid accumulation, and oxidative damage; upregulated fatty acid (FA) oxidation; and downregulated FA transport and lipogenesis. Histology of heart revealed that TX diminishes inflammatory cell infiltration and fatty degeneration in HFFD-fed mice. The antioxidant property of TX and its ability to influence lipid regulatory genes could be the underlying mechanisms for its beneficial effects.
C1 [Geetha, Rajagopalan; Yogalakshmi, Baskaran; Sreeja, S.; Anuradha, Carani Venkatraman] Annamalai Univ, Dept Biochem & Biotechnol, Annamalainagar 608002, Tamil Nadu, India.
   [Bhavani, K.] Mahatma Gandhi Med Coll & Res Inst, Dept Pathol, Pondicherry, India.
C3 Annamalai University; Mahatma Gandhi Medical College & Research
   Institute
RP Anuradha, CV (corresponding author), Annamalai Univ, Dept Biochem & Biotechnol, Annamalainagar 608002, Tamil Nadu, India.
EM cvaradha@hotmail.com
RI Venkatraman, Anuradha/U-8717-2019; S, SREEJA/KIK-7275-2024
OI Carani Venkatraman, Anuradha/0000-0001-9924-2533; S,
   SREEJA/0000-0002-1667-7492
FU Indian Council of Medical Research, New Delhi, India
FX The first author Mrs. Rajagopalan Geetha is a recipient of Senior
   Research Fellowship from the Indian Council of Medical Research, New
   Delhi, India.
CR Aasum E, 2008, J MOL CELL CARDIOL, V44, P201, DOI 10.1016/j.yjmcc.2007.08.020
   Anitha Nandhini A T, 2002, J Biochem Mol Biol Biophys, V6, P129, DOI 10.1080/10258140290027261
   Barger PM, 2000, TRENDS CARDIOVAS MED, V10, P238, DOI 10.1016/S1050-1738(00)00077-3
   Bhuvaneswari S, 2010, PROCESS BIOCHEM, V45, P1406, DOI 10.1016/j.procbio.2010.05.016
   BLASIG IE, 1987, BIOMED BIOCHIM ACTA, V46, pS539
   BLASIG IE, 1988, BIOMED BIOCHIM ACTA, V47, pS252
   BOISSEAU MR, 1995, J CARDIOVASC SURG, V36, P369
   BRACCO EF, 1983, P SOC EXP BIOL MED, V174, P143
   Bray GA, 2004, AM J CLIN NUTR, V79, P537
   Carley A. N., 2007, Archives of Physiology and Biochemistry, V113, P65, DOI 10.1080/13813450701422617
   Chicco A, 1999, NUTR RES, V19, P281, DOI 10.1016/S0271-5317(98)00191-2
   Deng JY, 2007, AM J PHYSIOL-HEART C, V293, pH978, DOI 10.1152/ajpheart.01002.2006
   Erion DM, 2010, NAT MED, V16, P400, DOI 10.1038/nm0410-400
   Fan SH, 2009, INT IMMUNOPHARMACOL, V9, P91, DOI 10.1016/j.intimp.2008.10.008
   Francini F, 2010, LIFE SCI, V86, P965, DOI 10.1016/j.lfs.2010.05.005
   Glatz JFC, 2010, PHYSIOL REV, V90, P367, DOI 10.1152/physrev.00003.2009
   Grassi G, 1999, J HYPERTENS, V17, P719, DOI 10.1097/00004872-199917060-00001
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Guerre-Millo M, 2000, J BIOL CHEM, V275, P16638, DOI 10.1074/jbc.275.22.16638
   Haluzík MM, 2006, PHYSIOL RES, V55, P115, DOI 10.33549/physiolres.930744
   Huang HY, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/943020
   JIANG ZY, 1992, ANAL BIOCHEM, V202, P384, DOI 10.1016/0003-2697(92)90122-N
   Kannappan S, 2010, EUR J PHARMACOL, V645, P177, DOI 10.1016/j.ejphar.2010.07.015
   Karthik D, 2011, J CARDIOVASC PHARM, V58, P514, DOI 10.1097/FJC.0b013e31822c265d
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   Kessler M, 2002, J DERMATOL TREAT, V13, P133, DOI 10.1080/09546630260199505
   Khullar M, 2010, CAN J PHYSIOL PHARM, V88, P233, DOI 10.1139/Y10-016
   Kim NH, 2008, BIOFACTORS, V33, P49, DOI 10.1002/biof.5520330105
   Ko HJ, 2009, DIABETES, V58, P2536, DOI 10.2337/db08-1361
   Kondo T, 2009, J AGR FOOD CHEM, V57, P5982, DOI 10.1021/jf900470c
   Li CJ, 2009, CHINESE MED J-PEKING, V122, P2580, DOI 10.3760/cma.j.issn.0366-6999.2009.21.010
   Liang HY, 2006, ADV PHYSIOL EDUC, V30, P145, DOI 10.1152/advan.00052.2006
   Liu CM, 2010, FOOD CHEM TOXICOL, V48, P2809, DOI 10.1016/j.fct.2010.07.011
   Lu J, 2011, BRAIN, V134, P783, DOI 10.1093/brain/awq376
   Luiken JJFP, 2004, PFLUG ARCH EUR J PHY, V448, P1, DOI 10.1007/s00424-003-1199-4
   Marfella R, 2009, J LIPID RES, V50, P2314, DOI 10.1194/jlr.P900032-JLR200
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Maurya DK, 2005, MOL CELL BIOCHEM, V280, P57, DOI 10.1007/s11010-005-8052-3
   McGavock JM, 2006, ANN INTERN MED, V144, P517, DOI 10.7326/0003-4819-144-7-200604040-00011
   Miranda PJ, 2005, AM HEART J, V149, P33, DOI 10.1016/j.ahj.2004.07.013
   Mooradian AD, 2009, NAT CLIN PRACT ENDOC, V5, P150, DOI 10.1038/ncpendmet1066
   Odermatt A, 2011, AM J PHYSIOL-RENAL, V301, pF919, DOI 10.1152/ajprenal.00068.2011
   Ouwens DM, 2007, DIABETOLOGIA, V50, P1938, DOI 10.1007/s00125-007-0735-8
   Panchal SK, 2011, J NUTR, V141, P1062, DOI 10.3945/jn.111.137877
   Pandey S, 2009, INT J DIABETES DEV C, V29, P52, DOI 10.4103/0973-3930.53120
   Potenza MV, 2009, NUTR CLIN PRACT, V24, P560, DOI 10.1177/0884533609342436
   Qin BL, 2010, MOL NUTR FOOD RES, V54, pS14, DOI 10.1002/mnfr.200900306
   RAO P, 1990, ANAL BIOCHEM, V189, P178, DOI 10.1016/0003-2697(90)90103-G
   Rault-Nania MH, 2008, CLIN NUTR, V27, P276, DOI 10.1016/j.clnu.2008.01.015
   Seddon M, 2007, HEART, V93, P903, DOI 10.1136/hrt.2005.068270
   Seo HY, 2013, ENDOCRINOLOGY, V154, P1722, DOI 10.1210/en.2012-2009
   Singh AK, 2008, KIDNEY INT, V74, P438, DOI 10.1038/ki.2008.184
   Sun SY, 2012, CLIN LAB, V58, P81
   Suwannaphet W, 2010, FOOD CHEM TOXICOL, V48, P1853, DOI 10.1016/j.fct.2010.04.021
   Thirunavukkarasu V, 2004, NUTR METAB CARDIOVAS, V14, P351, DOI 10.1016/S0939-4753(04)80025-5
   TONTONOZ P, 1993, MOL CELL BIOL, V13, P4753, DOI 10.1128/MCB.13.8.4753
   Vanithadevi B., 2008, INT J DIABETES METAB, V16, P35, DOI DOI 10.1159/000497651
   Wada T, 2010, ENDOCRINOLOGY, V151, P2040, DOI 10.1210/en.2009-0869
   Wenisch C, 2001, CURR MED RES OPIN, V17, P123, DOI 10.1185/030079901317010784
   Ye JM, 2001, DIABETES, V50, P411, DOI 10.2337/diabetes.50.2.411
NR 60
TC 38
Z9 38
U1 0
U2 18
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD FEB
PY 2014
VL 387
IS 1-2
BP 123
EP 134
DI 10.1007/s11010-013-1877-2
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA AA1AN
UT WOS:000330828600013
PM 24173620
DA 2025-06-11
ER

PT J
AU Page, GLJ
   Laight, D
   Cummings, MH
AF Page, G. L. J.
   Laight, D.
   Cummings, M. H.
TI Thiamine deficiency in diabetes mellitus and the impact of thiamine
   replacement on glucose metabolism and vascular disease
SO INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
LA English
DT Review
ID HIGH-DOSE THIAMINE; GLYCATION END-PRODUCTS; ENDOTHELIAL DYSFUNCTION;
   DOUBLE-BLIND; INTESTINAL TRANSPORT; OXIDATIVE STRESS; PHOSPHATE-ESTERS;
   WHOLE-BLOOD; BENFOTIAMINE; CELLS
AB P>Despite the targeting of traditional risk factors for cardiovascular disease, disease burden has not been completely eliminated. Thiamine is an essential cofactor in carbohydrate metabolism and individuals with diabetes are thiamine deficient. The pathophysiology of recognised complications of thiamine deficiency is similar to that underlying atherosclerosis and the metabolic syndrome, namely oxidative stress, inflammation and endothelial dysfunction. This review examines the mechanisms by which thiamine deficiency occurs in individuals with diabetes, how this deficiency leads to hyperglycaemic-induced damage, and the effect of thiamine replacement on vascular disease, endothelial function and oxidative stress. Thiamine administration can prevent the formation of harmful by-products of glucose metabolism, reduce oxidative stress and improve endothelial function. The potential benefit of long-term replacement in those with diabetes is not yet known but may reduce cardiovascular risk and angiopathic complications.
C1 [Page, G. L. J.; Cummings, M. H.] Queen Alexandra Hosp, Acad Dept Diabet & Endocrinol, Portsmouth, Hants, England.
   [Laight, D.] Univ Portsmouth, Sch Pharm & Biomed Sci, Portsmouth, Hants, England.
C3 Portsmouth Hospitals NHS Trust; Queen Alexandra Hospital; University of
   Portsmouth
RP Page, GLJ (corresponding author), Queen Alexandra Hosp, Acad Dept Diabet & Endocrinol, Southwick Hill Rd, Portsmouth, Hants, England.
EM georgina.page@porthosp.nhs.uk
CR Alkhalaf A, 2010, DIABETES CARE, V33, P1598, DOI 10.2337/dc09-2241
   [Anonymous], SAFE UPPER LEVELS VI
   Arora S, 2006, ANN VASC SURG, V20, P653, DOI 10.1007/s10016-006-9055-6
   Ascher E, 2001, SURGERY, V130, P851, DOI 10.1067/msy.2001.117194
   Ashokkumar B, 2006, AM J PHYSIOL-RENAL, V291, pF796, DOI 10.1152/ajprenal.00078.2006
   Babaei-Jadidi R, 2004, DIABETOLOGIA, V47, P2235, DOI 10.1007/s00125-004-1582-5
   Babaei-Jadidi R, 2003, DIABETES, V52, P2110, DOI 10.2337/diabetes.52.8.2110
   Balakumar P, 2008, PHARMACOL RES, V58, P356, DOI 10.1016/j.phrs.2008.09.012
   Balakumar P, 2009, MOL CELL BIOCHEM, V320, P149, DOI 10.1007/s11010-008-9917-z
   Beltramo E, 2009, DIABETES-METAB RES, V25, P647, DOI 10.1002/dmrr.1008
   Berrone E, 2006, J BIOL CHEM, V281, P9307, DOI 10.1074/jbc.M600418200
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   DAY E, 2004, COCHRANE DB SYST REV, DOI DOI 10.1002/14651858.CD004033.PUB2
   De Palma C, 2008, J NEUROCHEM, V106, P193, DOI 10.1111/j.1471-4159.2008.05351.x
   Du X, 2008, DIABETOLOGIA, V51, P1930, DOI 10.1007/s00125-008-1100-2
   González-Ortiz M, 2011, EUR J NUTR, V50, P145, DOI 10.1007/s00394-010-0123-x
   Hammes HP, 2003, NAT MED, V9, P294, DOI 10.1038/nm834
   Hartge MM, 2006, ENDOCRIN METAB CLIN, V35, P551, DOI 10.1016/j.ecl.2006.06.006
   Hazell AS, 2009, ALCOHOL ALCOHOLISM, V44, P141, DOI 10.1093/alcalc/agn120
   Jermendy Gyorgy, 2006, Diab Vasc Dis Res, V3, P120, DOI 10.3132/dvdr.2006.014
   Karachalias N, 2010, DIABETOLOGIA, V53, P1506, DOI 10.1007/s00125-010-1722-z
   LaSelva M, 1996, DIABETOLOGIA, V39, P1263
   LEMOINE A, 1980, AM J CLIN NUTR, V33, P2595, DOI 10.1093/ajcn/33.12.2595
   Lu J, 2008, CLIN CHEM, V54, P901, DOI 10.1373/clinchem.2007.099077
   Lukienko PI, 2000, B EXP BIOL MED+, V130, P874, DOI 10.1023/A:1015318413076
   Martinez-Villaluenga C, 2009, J FOOD SCI, V74, pC49, DOI 10.1111/j.1750-3841.2008.01008.x
   Mee L, 2009, AM J PHYSIOL-GASTR L, V297, pG197, DOI 10.1152/ajpgi.00092.2009
   Moallem Seyed Adel, 2008, Iran Biomed J, V12, P173
   Pácal L, 2011, NEPHROL DIAL TRANSPL, V26, P1229, DOI 10.1093/ndt/gfq550
   Patrini C, 1996, J PHYSIOL-LONDON, V493P, pS100
   Rabbani N, 2009, DIABETOLOGIA, V52, P208, DOI 10.1007/s00125-008-1224-4
   Riaz S, 2011, J PHARMACEUT BIOMED, V54, P817, DOI 10.1016/j.jpba.2010.11.008
   Rindi G, 2000, P SOC EXP BIOL MED, V224, P246, DOI 10.1046/j.1525-1373.2000.22428.x
   SAITO N, 1987, J NUTR SCI VITAMINOL, V33, P421, DOI 10.3177/jnsv.33.421
   Sánchez-Ramírez GM, 2006, EUR J PHARMACOL, V530, P48, DOI 10.1016/j.ejphar.2005.11.016
   Schmid U, 2008, DIABETES-METAB RES, V24, P371, DOI 10.1002/dmrr.860
   Schreeb KH, 1997, EUR J CLIN PHARMACOL, V52, P319
   Schupp N, 2008, N-S ARCH PHARMACOL, V378, P283, DOI 10.1007/s00210-008-0310-y
   Stehouwer CDA, 1996, EUR J CLIN INVEST, V26, P535, DOI 10.1046/j.1365-2362.1996.1780527.x
   Stehouwer CDA, 2006, J AM SOC NEPHROL, V17, P2106, DOI 10.1681/ASN.2005121288
   Stirban A, 2006, DIABETES CARE, V29, P2064, DOI 10.2337/dc06-0531
   Stracke H, 2008, EXP CLIN ENDOCR DIAB, V116, P600, DOI 10.1055/s-2008-1065351
   Tallaksen CME, 1997, METHOD ENZYMOL, V279, P67
   Talwar D, 2000, CLIN CHEM, V46, P704
   Thomson AD, 2002, ALCOHOL ALCOHOLISM, V37, P513, DOI 10.1093/alcalc/37.6.513
   Thornalley PJ, 2007, DIABETOLOGIA, V50, P2164, DOI 10.1007/s00125-007-0771-4
   THORNALLEY PJ, 2010, DIABETIC MED, V27, P74
   Valerio G, 1999, ACTA DIABETOL, V36, P73, DOI 10.1007/s005920050148
   Verma S, 2010, BIOL TRACE ELEM RES, V137, P96, DOI 10.1007/s12011-009-8567-7
   Vindedzis SA, 2008, DIABETES VASC DIS RE, V5, P215, DOI 10.3132/dvdr.2008.035
   Wong CY, 2008, MOL NUTR FOOD RES, V52, P1421, DOI 10.1002/mnfr.200800056
NR 51
TC 102
Z9 113
U1 0
U2 10
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-5031
J9 INT J CLIN PRACT
JI Int. J. Clin. Pract.
PD JUN
PY 2011
VL 65
IS 6
BP 684
EP 690
DI 10.1111/j.1742-1241.2011.02680.x
PG 7
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA 762OF
UT WOS:000290488600013
PM 21564442
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU D'Angelo, S
AF D'Angelo, Stefania
TI Diet and Aging: The Role of Polyphenol-Rich Diets in Slow Down the
   Shortening of Telomeres: A Review
SO ANTIOXIDANTS
LA English
DT Review
DE Mediterranean diet; oxidative stress; antioxidant; telomere length;
   polyphenol; aging; nutrition; longevity
ID MEDITERRANEAN DIET; LIFE-STYLE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   TEA CONSUMPTION; FOOD GROUPS; BLACK TEA; LENGTH; BIOAVAILABILITY;
   RESVERATROL
AB The ends of human chromosomes are defended by DNA-protein complexes named telomeres, which inhibit the chromosomes from fusing with each other and from being known as a double-strand break by DNA reparation proteins. Telomere length is a marker of biological aging, and disfunction of telomeres is related to age-related syndromes. Telomere attrition has been shown to be accelerated by oxidative stress and inflammation. Telomere length has been proven to be positively linked with nutritional status in human and animal scientific research as several nutrients influence it through mechanisms that imitate their function in cellular roles including oxidative stress and inflammation. Data reported in this article support the idea that following a low-in-fat and rich-plant polyphenols food diet seems to be able to slow down the shortening of telomeres.
C1 [D'Angelo, Stefania] Parthenope Univ, Dept Med Movement & Wellbeing Sci, I-80133 Naples, Italy.
C3 Parthenope University Naples
RP D'Angelo, S (corresponding author), Parthenope Univ, Dept Med Movement & Wellbeing Sci, I-80133 Naples, Italy.
EM stefania.dangelo@uniparthenope.it
RI D'Angelo, Stefania/AAI-2594-2019
OI D'Angelo, Stefania/0000-0001-7585-5052
FU Miur
FX No Statement Available
CR Abbott A, 2009, NATURE, V461, P706, DOI 10.1038/461706a
   Ahmad FB, 2021, JAMA-J AM MED ASSOC, V325, P1829, DOI 10.1001/jama.2021.5469
   Alasalvar C, 2021, COMPR REV FOOD SCI F, V20, P2382, DOI 10.1111/1541-4337.12730
   Arsenis NC, 2017, ONCOTARGET, V8, P45008, DOI 10.18632/oncotarget.16726
   Augimeri Giuseppina, 2023, Oxidative Medicine and Cellular Longevity, V2023, P1555942, DOI 10.1155/2023/1555942
   Aunan JR, 2016, BRIT J SURG, V103, pE29, DOI 10.1002/bjs.10053
   Aviv A., 2004, SCI AGING KNOWLEDGE, V2004, pp
   Aviv A, 2009, AM J EPIDEMIOL, V169, P323, DOI 10.1093/aje/kwn338
   Berry EM, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092229
   Boccardi V, 2016, AGING-US, V8, P12, DOI 10.18632/aging.100886
   Boccardi V, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0062781
   Boccellino M, 2021, CURR NUTR FOOD SCI, V17, P111, DOI 10.2174/1573401316999200504093028
   Boccellino M, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21165642
   Cai ZY, 2018, MOLECULES, V23, DOI 10.3390/molecules23092346
   Calado RT, 2009, NEW ENGL J MED, V361, P2353, DOI 10.1056/NEJMra0903373
   Canudas S, 2020, ADV NUTR, V11, P1544, DOI 10.1093/advances/nmaa079
   Carbonell-Capella JM, 2014, COMPR REV FOOD SCI F, V13, P155, DOI 10.1111/1541-4337.12049
   Cardona F, 2013, J NUTR BIOCHEM, V24, P1415, DOI 10.1016/j.jnutbio.2013.05.001
   Andreo-López MC, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24054491
   Barbosa MC, 2019, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00790
   Cassidy A, 2010, AM J CLIN NUTR, V91, P1273, DOI 10.3945/ajcn.2009.28947
   Chakravarti D, 2021, CELL, V184, P306, DOI 10.1016/j.cell.2020.12.028
   Chan R, 2010, BRIT J NUTR, V103, P107, DOI 10.1017/S0007114509991383
   Chow HHS, 2011, PHARMACOL RES, V64, P105, DOI 10.1016/j.phrs.2011.05.007
   Cory H, 2018, FRONT NUTR, V5, DOI 10.3389/fnut.2018.00087
   Crous-Bou M, 2019, ADV NUTR, V10, pS296, DOI 10.1093/advances/nmz026
   Crous-Bou M, 2014, BMJ-BRIT MED J, V349, DOI 10.1136/bmj.g6674
   D'Angelo S, 2020, CURR NUTR FOOD SCI, V16, P1170, DOI 10.2174/1573401316999200714160126
   D'Angelo S, 2020, CURR SPORT MED REP, V19, P260, DOI 10.1249/JSR.0000000000000729
   D'Angelo Stefania, 2020, Sport Science, V13, P29
   D'Angelo Stefania, 2020, Sport Science, V13, P7
   D'Angelo Stefania, 2020, Sport Science, V13, P58
   D'Angelo S, 2019, CURR NUTR FOOD SCI, V15, P745, DOI 10.2174/1573401315666190206142025
   D'Angelo S, 2017, INT J ONCOL, V51, P939, DOI 10.3892/ijo.2017.4088
   D'Angelo S, 2015, CURR NUTR FOOD SCI, V11, P248, DOI 10.2174/1573401311666150610210529
   da Costa JP, 2016, AGEING RES REV, V29, P90, DOI 10.1016/j.arr.2016.06.005
   da Luz PL, 2012, ATHEROSCLEROSIS, V224, P136, DOI 10.1016/j.atherosclerosis.2012.06.007
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   De Bacquer D, 2006, ATHEROSCLEROSIS, V189, P428, DOI 10.1016/j.atherosclerosis.2005.12.028
   de Vos-Houben JMJ, 2012, MECH AGEING DEV, V133, P373, DOI 10.1016/j.mad.2012.04.003
   Di Daniele N, 2017, ONCOTARGET, V8, P8947, DOI 10.18632/oncotarget.13553
   Di Lorenzo C, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010273
   Dinu M, 2018, EUR J CLIN NUTR, V72, P30, DOI 10.1038/ejcn.2017.58
   Dominguez LJ, 2021, NUTRIENTS, V13, DOI 10.3390/nu13062028
   Eleftheriou D, 2018, BRIT J NUTR, V120, P1081, DOI 10.1017/S0007114518002593
   Fang J, 2014, DRUG METAB REV, V46, P508, DOI 10.3109/03602532.2014.978080
   Farhan M, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms231810713
   Ferrara L., 2021, J. Phys. Educ. Sport, V21, P425, DOI DOI 10.7752/JPES.2021.01042
   Ferrara Luigi, 2023, Journal of Physical Education and Sport, V23, P2274, DOI 10.7752/jpes.2023.09261
   Ferrara L, 2022, CURR NUTR FOOD SCI, V18, P785, DOI 10.2174/1573401318666220317140717
   Ferrara L, 2022, CURR NUTR FOOD SCI, V18, P618, DOI 10.2174/1573401318666220407101325
   Ferro M, 2021, THER ADV UROL, V13, DOI 10.1177/17562872211026404
   Almeida AF, 2018, COMPR REV FOOD SCI F, V17, P714, DOI 10.1111/1541-4337.12342
   Freitas-Simoes TM, 2016, METABOLISM, V65, P406, DOI 10.1016/j.metabol.2015.11.004
   García-Calzón S, 2016, CLIN NUTR, V35, P1399, DOI 10.1016/j.clnu.2016.03.013
   Gardner EJ, 2007, EUR J CLIN NUTR, V61, P3, DOI 10.1038/sj.ejcn.1602489
   Giacosa A, 2016, CRIT REV FOOD SCI, V56, P635, DOI 10.1080/10408398.2012.747484
   Godos J, 2017, INT J FOOD SCI NUTR, V68, P138, DOI 10.1080/09637486.2016.1221900
   Gomes EC, 2012, OXID MED CELL LONGEV, V2012, DOI 10.1155/2012/756132
   Gomez-Delgado F, 2018, J GERONTOL A-BIOL, V73, P327, DOI 10.1093/gerona/glw194
   Gong YH, 2018, CLIN NUTR, V37, P1232, DOI 10.1016/j.clnu.2017.05.005
   Grosso G, 2017, CRIT REV FOOD SCI, V57, P3218, DOI 10.1080/10408398.2015.1107021
   Gu Y, 2015, AGE, V37, DOI 10.1007/s11357-015-9758-0
   Guasch-Ferré M, 2021, J INTERN MED, V290, P549, DOI 10.1111/joim.13333
   He SJ, 2022, RENAL FAILURE, V44, P171, DOI 10.1080/0886022X.2022.2029488
   Hohensinner PJ, 2011, AGING DIS, V2, P524
   Hornsby PJ, 2007, EXP GERONTOL, V42, P575, DOI 10.1016/j.exger.2007.03.007
   Huang PX, 2015, ONCOTARGET, V6, P10812, DOI 10.18632/oncotarget.3580
   Hussain T, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/7432797
   Jayasena T, 2013, AGEING RES REV, V12, P867, DOI 10.1016/j.arr.2013.06.003
   Jin KL, 2010, AGING DIS, V1, P72
   Karimi B, 2018, AM J MENS HEALTH, V12, P479, DOI 10.1177/1557988317743385
   Kiani Aysha Karim, 2022, J Prev Med Hyg, V63, pE36, DOI 10.15167/2421-4248/jpmh2022.63.2S3.2745
   Lassale C, 2019, MOL PSYCHIATR, V24, P965, DOI 10.1038/s41380-018-0237-8
   Lee JY, 2015, EUR J CLIN NUTR, V69, P1048, DOI 10.1038/ejcn.2015.58
   Lee Ronald, 2017, Finance Dev, V54, P7
   Li YR, 2018, BIOFACTORS, V44, P69, DOI 10.1002/biof.1400
   Ling ZX, 2022, CRIT REV FOOD SCI, V62, P3509, DOI 10.1080/10408398.2020.1867054
   López-Otin C, 2023, CELL, V186, P243, DOI 10.1016/j.cell.2022.11.001
   López-Otín C, 2013, CELL, V153, P1194, DOI 10.1016/j.cell.2013.05.039
   Luo CH, 2022, MOLECULES, V27, DOI 10.3390/molecules27217377
   Maleki M, 2020, LIFE SCI, V259, DOI 10.1016/j.lfs.2020.118341
   Manach C, 2005, AM J CLIN NUTR, V81, p230S, DOI 10.1093/ajcn/81.1.230S
   Marin C, 2012, AGE, V34, P1309, DOI 10.1007/s11357-011-9305-6
   Martín-Peláez S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12082236
   Martínez-González MA, 2019, CIRC RES, V124, P779, DOI 10.1161/CIRCRESAHA.118.313348
   Martínez-González MA, 2015, PROG CARDIOVASC DIS, V58, P50, DOI 10.1016/j.pcad.2015.04.003
   Martino E, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-49631-x
   McGrattan AM, 2019, CURR NUTR REP, V8, P53, DOI 10.1007/s13668-019-0271-4
   McHugh D, 2018, J CELL BIOL, V217, P65, DOI 10.1083/jcb.201708092
   Meccariello R, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10040507
   Mentella MC, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092059
   Milte CM, 2018, EUR J NUTR, V57, P363, DOI 10.1007/s00394-016-1326-6
   Min KB, 2017, EUR J NUTR, V56, P1045, DOI 10.1007/s00394-016-1152-x
   Mocciaro G, 2018, INT J FOOD SCI NUTR, V69, P524, DOI 10.1080/09637486.2017.1391752
   Moghadam D, 2023, MOL BIOL REP, V50, P77, DOI 10.1007/s11033-022-08031-7
   Morselli E, 2010, CELL DEATH DIS, V1, DOI 10.1038/cddis.2009.8
   Müezzinler A, 2013, AGEING RES REV, V12, P509, DOI 10.1016/j.arr.2013.01.003
   Nettleton JA, 2008, AM J CLIN NUTR, V88, P1405, DOI 10.3945/ajcn.2008.26429
   Nisticò S, 2015, J BIOL REG HOMEOS AG, V29, P723
   Oeseburg H, 2010, PFLUG ARCH EUR J PHY, V459, P259, DOI 10.1007/s00424-009-0728-1
   Omidifar N, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/7501424
   Ornish D, 2008, LANCET ONCOL, V9, P1048, DOI 10.1016/S1470-2045(08)70234-1
   Paul L, 2011, J NUTR BIOCHEM, V22, P895, DOI 10.1016/j.jnutbio.2010.12.001
   Pereira QC, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24065508
   Pérez-Jiménez J, 2011, AM J CLIN NUTR, V93, P1220, DOI 10.3945/ajcn.110.007096
   Pes GM, 2022, MATURITAS, V164, P31, DOI 10.1016/j.maturitas.2022.06.004
   Pizza V., 2013, Curr. Neurobiol, V4, P93
   Pizza V, 2020, MEDICINA-LITHUANIA, V56, DOI 10.3390/medicina56050218
   Porquet D, 2013, AGE, V35, P1851, DOI 10.1007/s11357-012-9489-4
   Rafie N, 2017, EUR J CLIN NUTR, V71, P151, DOI 10.1038/ejcn.2016.149
   Real H, 2020, INT J FOOD SCI NUTR, V71, P1, DOI 10.1080/09637486.2019.1617838
   Rein MJ, 2013, BRIT J CLIN PHARMACO, V75, P588, DOI 10.1111/j.1365-2125.2012.04425.x
   Rajoka MSR, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10101563
   Salehi A., 2019, Journal of Mazandaran University of Medical Sciences, V28, P211
   Santhakumar AB, 2018, FOOD CHEM TOXICOL, V113, P49, DOI 10.1016/j.fct.2018.01.022
   Santos-Buelga C, 2021, MOLECULES, V26, DOI 10.3390/molecules26185537
   Scalbert A, 2000, J NUTR, V130, p2073S, DOI 10.1093/jn/130.8.2073S
   Schmidt JC, 2015, GENE DEV, V29, P1095, DOI 10.1101/gad.263863.115
   Schwingshackl L, 2015, PUBLIC HEALTH NUTR, V18, P1292, DOI 10.1017/S1368980014001542
   Sepich-Poore GD, 2021, SCIENCE, V371, P1331, DOI 10.1126/science.abc4552
   Shakoor H, 2021, NUTRIENTS, V13, DOI 10.3390/nu13030728
   Shay JW, 2007, J PATHOL, V211, P114, DOI 10.1002/path.2090
   Shay JW, 2019, NAT REV GENET, V20, P299, DOI 10.1038/s41576-019-0099-1
   Sheng R, 2013, INT J CARDIOL, V162, P199, DOI 10.1016/j.ijcard.2011.07.083
   Shi John, 2003, Journal of Medicinal Food, V6, P291, DOI 10.1089/109662003772519831
   Siervo M, 2015, BRIT J NUTR, V113, P1, DOI 10.1017/S0007114514003341
   Singla RK, 2019, J AOAC INT, V102, P1397, DOI [10.1093/jaoac/102.5.1397, 10.5740/jaoacint.19-0133]
   Sorrenti V, 2023, ADV NUTR, V14, P1111, DOI 10.1016/j.advnut.2023.05.014
   Sorrenti V, 2020, NUTRIENTS, V12, DOI 10.3390/nu12071908
   Sorrenti V, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051265
   Swallah MS, 2020, INT J FOOD SCI, V2020, DOI 10.1155/2020/9081686
   Teng H, 2019, CRIT REV FOOD SCI, V59, P2040, DOI 10.1080/10408398.2018.1437023
   Thomas P, 2009, MUTAT RES-FUND MOL M, V661, P25, DOI 10.1016/j.mrfmmm.2008.10.016
   Tosti V, 2018, J GERONTOL A-BIOL, V73, P318, DOI 10.1093/gerona/glx227
   Trichopoulou A, 2003, NEW ENGL J MED, V348, P2599, DOI 10.1056/NEJMoa025039
   Tucker LA, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051415
   Uchiumi Fumiaki, 2011, Curr Aging Sci, V4, P1
   Vasto S, 2014, CURR VASC PHARMACOL, V12, P735
   von Zglinicki T, 2002, TRENDS BIOCHEM SCI, V27, P339, DOI 10.1016/S0968-0004(02)02110-2
   Vuoso DC, 2020, CURR NUTR FOOD SCI, V16, P1149, DOI 10.2174/1573401316666200217113808
   Vuoso DC, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-73092-2
   Walter J, 2011, ANNU REV MICROBIOL, V65, P411, DOI 10.1146/annurev-micro-090110-102830
   Wang XB, 2011, CHINESE MED J-PEKING, V124, P4310, DOI 10.3760/cma.j.issn.0366-6999.2011.24.033
   Warden BA, 2001, J NUTR, V131, P1731, DOI 10.1093/jn/131.6.1731
   Williamson G, 2017, NUTR BULL, V42, P226, DOI 10.1111/nbu.12278
   Wu BJ, 2011, J PHARM SCI-US, V100, P3655, DOI 10.1002/jps.22568
   Yabuta S, 2016, J NUTR HEALTH AGING, V20, P267, DOI 10.1007/s12603-015-0577-x
   Zbeida M, 2014, J NUTR HEALTH AGING, V18, P411, DOI 10.1007/s12603-014-0003-9
   Zole E, 2018, BIOGERONTOLOGY, V19, P189, DOI 10.1007/s10522-018-9748-6
NR 150
TC 16
Z9 16
U1 3
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD DEC
PY 2023
VL 12
IS 12
AR 2086
DI 10.3390/antiox12122086
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA DH2A0
UT WOS:001131060300001
PM 38136206
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Li, C
   Liu, Q
   Xie, LQ
AF Li, Chen
   Liu, Qing
   Xie, Liqun
TI Suppressing NLRP2 expression accelerates hepatic steatosis: A mechanism
   involving inflammation and oxidative stress
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE NAFLD; NLRP2; Inflammation; Oxidative stress; Nrf2
ID NF-KAPPA-B; FATTY LIVER-DISEASE; NAFLD; ACTIVATION; HEPATOCYTES;
   PATHWAY; PROTEIN; NRF2; MICE
AB Nonalcoholic fatty liver disease (NAFLD) is characterized by lipid accumulation and inflammation in the liver, contributing to a broad spectrum of severe pathologies, such as metabolic syndrome and hepatocellular carcinoma. Presently, the pathogenesis that attributes to NAFLD has not been fully understood. NLRP2 has been shown to inhibit the NF-kappa B signaling, and thus may contribute to regulate the inflammatory response. However, its role in NAFLD is largely unclear. In the study, we found that NLRP2 was markedly decreased in liver tissues of individuals with severe steatosis, or in a genetic deficiency (ob/ob) mice. High fat diet (HFD) feeding also led to a significant reduction of NLRP2 in liver of mice. Then, the wild type (WT) and NLRP2 knockout (KO) mice were used to further explore the role of NLRP2 in the NAFLD progression. NLRP2 knockout mice exhibited severer metabolic syndrome and hepatic steatosis after HFD administration, as evidenced by the increased body weight, liver histological changes and lipid accumulation. Moreover, HFD feeding-induced inflammation was significantly accelerated by the loss of NLRP2, as evidenced by the increased expression of pro-inflammatory cytokines and activation of nuclear factor kappa B (NF-kappa B) pathway. In addition, oxidative stress triggered by HFD was further promoted by NLRP2 deletion through repressing NF-E2-related factor 2 (Nrf2) pathway. In vitro, we surprisingly found that promoting Nrf2 activation could attenuate NLRP2 knockout-accelerated inflammation and reactive oxygen species (ROS) generation. Therefore, our study indicated that NLRP2 might be a potential target for developing effective therapeutic strategy to prevent NAFLD progression. (C) 2018 Published by Elsevier Inc.
C1 [Li, Chen] Nanjing Univ Chinese Med, Xuzhou TCM Hosp, Dept Gastroenterol, Xuzhou 221000, Jiangsu, Peoples R China.
   [Liu, Qing] Nanjing Univ Chinese Med, Xuzhou TCM Hosp, Dept Oncol, Xuzhou 221000, Jiangsu, Peoples R China.
   [Xie, Liqun] Nanjing Med Univ, Affiliated Hosp 1, Dept Tradit Chinese Med, Nanjing 210009, Jiangsu, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine; Nanjing Medical University
RP Xie, LQ (corresponding author), Nanjing Med Univ, Affiliated Hosp 1, Dept Tradit Chinese Med, Nanjing 210009, Jiangsu, Peoples R China.
EM liqunxienmu@foxmail.com
FU 4th China National TCM Excellent Talents Training Projects; Jiangsu
   Province TCM Excellent Talents Training Projects 2017 of China; Program
   for youth medical reserve talents of Jiangsu Province of China
   [QNRC2016394]; Project of Administration of Traditional Chinese Medicine
   of Jiang Su Province of China [YB2017088, YB2015085]; Project of Xuzhou
   Science and Technology Bureau of Jiang Su Province of China [KC15SH035];
   Program for Xuzhou youth medical reserve talents of China
FX This work was supported by The 4th China National TCM Excellent Talents
   Training Projects 2017; The Jiangsu Province TCM Excellent Talents
   Training Projects 2017 of China; Program for youth medical reserve
   talents of Jiangsu Province of China (ID: QNRC2016394); Project of
   Administration of Traditional Chinese Medicine of Jiang Su Province of
   China (ID:YB2015085); Project of Administration of Traditional Chinese
   Medicine of Jiang Su Province of China (ID:YB2017088); Project of Xuzhou
   Science and Technology Bureau of Jiang Su Province of China
   (ID:KC15SH035); Program for Xuzhou youth medical reserve talents of
   China.
CR Alfonso-Loeches S, 2014, FRONT CELL NEUROSCI, V8, DOI 10.3389/fncel.2014.00216
   Ballestri S, 2016, ADV THER, V33, P291, DOI 10.1007/s12325-016-0306-9
   Bruey JM, 2004, J BIOL CHEM, V279, P51897, DOI 10.1074/jbc.M406741200
   Brunt EM, 2009, HEPATOLOGY, V49, P809, DOI 10.1002/hep.22724
   Catrysse L, 2017, TRENDS CELL BIOL, V27, P417, DOI 10.1016/j.tcb.2017.01.006
   Cichoz-Lach H, 2014, WORLD J GASTROENTERO, V20, P8082, DOI 10.3748/wjg.v20.i25.8082
   Corridoni D, 2014, FRONT IMMUNOL, V5, DOI 10.3389/fimmu.2014.00317
   De Nicola GM, 2011, NATURE, V475, P106, DOI 10.1038/nature10189
   Dela Peña A, 2005, GASTROENTEROLOGY, V129, P1663, DOI 10.1053/j.gastro.2005.09.004
   Fontalba A, 2007, J IMMUNOL, V179, P8519, DOI 10.4049/jimmunol.179.12.8519
   Henao-Mejia J, 2012, NATURE, V482, P179, DOI 10.1038/nature10809
   Kim DY, 2009, J AGR FOOD CHEM, V57, P1532, DOI 10.1021/jf802867b
   Kinoshita T, 2005, J BIOL CHEM, V280, P21720, DOI 10.1074/jbc.M410057200
   Kuchmiy AA, 2016, J EXP MED, V213, P2851, DOI 10.1084/jem.20160900
   Lin MJ, 2017, ONCOTARGET, V8, P108802, DOI 10.18632/oncotarget.22163
   Martin SD, 2014, MOL METAB, V3, P408, DOI 10.1016/j.molmet.2014.02.001
   Meyer E, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000423
   Minutoli Letteria, 2016, Oxid Med Cell Longev, V2016, P2183026, DOI 10.1155/2016/2183026
   Miura K, 2010, GASTROENTEROLOGY, V139, P323, DOI 10.1053/j.gastro.2010.03.052
   Ni HM, 2013, AM J PATHOL, V183, P1815, DOI 10.1016/j.ajpath.2013.08.011
   Niu BL, 2018, MOL MED REP, V18, P1609, DOI 10.3892/mmr.2018.9088
   Parola M, 2016, J HEPATOL, V65, P470, DOI 10.1016/j.jhep.2016.05.042
   Pasarín M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0032785
   Shoelson SE, 2007, GASTROENTEROLOGY, V132, P2169, DOI 10.1053/j.gastro.2007.03.059
   Siti HN, 2015, VASC PHARMACOL, V71, P40, DOI 10.1016/j.vph.2015.03.005
   Sun SB, 2018, REDOX BIOL, V14, P338, DOI 10.1016/j.redox.2017.09.011
   Thaiss CA, 2016, NATURE, V535, P65, DOI 10.1038/nature18847
   Tian YL, 2016, MOL CELL BIOCHEM, V422, P75, DOI 10.1007/s11010-016-2807-x
   Tilburgs T, 2017, BIOL REPROD, V96, P831, DOI 10.1093/biolre/iox009
   Wang XB, 2015, EUR J PHARMACOL, V764, P94, DOI 10.1016/j.ejphar.2015.06.044
   Xin Y, 2018, REDOX BIOL, V15, P405, DOI 10.1016/j.redox.2017.12.016
   Y. Guo, 2017, J MOL ENDOCRINOL
   Yang X, 2017, REDOX BIOL, V12, P264, DOI 10.1016/j.redox.2017.02.020
   Younossi ZM, 2017, HEPATOLOGY
   Younossi Z, 2018, NAT REV GASTRO HEPAT, V15, P11, DOI 10.1038/nrgastro.2017.109
   Younossi ZM, 2015, HEPATOLOGY, V62, P1723, DOI 10.1002/hep.28123
   Zhao XJ, 2018, REDOX BIOL, V18, P124, DOI 10.1016/j.redox.2018.07.002
NR 37
TC 16
Z9 18
U1 4
U2 25
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD DEC 9
PY 2018
VL 507
IS 1-4
BP 22
EP 29
DI 10.1016/j.bbrc.2018.10.132
PG 8
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA HD8OM
UT WOS:000452816400004
PM 30454891
DA 2025-06-11
ER

PT J
AU Gerber, PA
   Rutter, GA
AF Gerber, Philipp A.
   Rutter, Guy A.
TI The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell
   Dysfunction in Diabetes Mellitus
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
DE insulin secretion; hypoxia; zinc; diabetes; beta cell
ID GENOME-WIDE ASSOCIATION; GLYCEROL-PHOSPHATE DEHYDROGENASE; IMPAIRED
   INSULIN-SECRETION; TRANSCRIPTION FACTOR PDX-1; OXYGEN SPECIES
   PRODUCTION; OBSTRUCTIVE SLEEP-APNEA; GLUTATHIONE REDOX STATE;
   FATTY-ACID-METABOLISM; CHELATING-AGENT TPEN; FREE CYTOSOLIC ZN2+
AB Significance: Metabolic syndrome is a frequent precursor of type 2 diabetes mellitus (T2D), a disease that currently affects similar to 8% of the adult population worldwide. Pancreatic beta-cell dysfunction and loss are central to the disease process, although understanding of the underlying molecular mechanisms is still fragmentary.
   Recent Advances: Oversupply of nutrients, including glucose and fatty acids, and the subsequent overstimulation of beta cells, are believed to be an important contributor to insulin secretory failure in T2D. Hypoxia has also recently been implicated in beta-cell damage. Accumulating evidence points to a role for oxidative stress in both processes. Although the production of reactive oxygen species (ROS) results from enhanced mitochondrial respiration during stimulation with glucose and other fuels, the expression of antioxidant defense genes is unusually low (or disallowed) in beta cells.
   Critical Issues: Not all subjects with metabolic syndrome and hyperglycemia go on to develop full-blown diabetes, implying an important role in disease risk for gene-environment interactions. Possession of common risk alleles at the SLC30A8 locus, encoding the beta-cell granule zinc transporter ZnT8, may affect cytosolic Zn2+ concentrations and thus susceptibility to hypoxia and oxidative stress.
   Future Directions: Loss of normal beta-cell function, rather than total mass, is increasingly considered to be the major driver for impaired insulin secretion in diabetes. Better understanding of the role of oxidative changes, its modulation by genes involved in disease risk, and effects on beta-cell identity may facilitate the development of new therapeutic strategies to this disease.
C1 [Gerber, Philipp A.] Univ Zurich Hosp, Dept Endocrinol, Diabet & Clin Nutr, Zurich, Switzerland.
   [Rutter, Guy A.] Imperial Coll London, Dept Med, Sect Cell Biol & Funct Genom, Hammersmith Campus, London W12 0NN, England.
C3 University of Zurich; University Zurich Hospital; Imperial College
   London
RP Rutter, GA (corresponding author), Imperial Coll London, Dept Med, Sect Cell Biol & Funct Genom, Hammersmith Campus, London W12 0NN, England.
EM g.rutter@imperial.ac.uk
RI Gerber, Philipp/C-2145-2015
OI Gerber, Philipp/0000-0002-2476-7076; Rutter, Guy/0000-0001-6360-0343
FU Wellcome Trust (Senior Investigator Award) [WT098424AIA]; MRC Programme
   Grant [MR/J0003042/1]; Biotechnology and Biological Sciences Research
   Council [BB/J015873/1]; Diabetes UK [11/0004210]; Imperial Confidence in
   Concept (ICiC) grant; Royal Society Wolfson Research Merit Award;
   Foundation of Diabetes Research at the University Hospital Zurich;
   Innovative Medicines Initiative Joint Undertaking (IMIDIA) [155005];
   European Union's SeventhFramework Programme (FP7); European Federation
   of Pharmaceutical Industries and Associations (EFPIA) companies; BBSRC
   [BB/J015873/1] Funding Source: UKRI; MRC [MR/K001981/1] Funding Source:
   UKRI
FX GAR is supported by grants from the Wellcome Trust (Senior Investigator
   Award, WT098424AIA), an MRC Programme Grant (MR/J0003042/1),
   Biotechnology and Biological Sciences Research Council (BB/J015873/1)
   and Diabetes UK (11/0004210) project grants, an Imperial Confidence in
   Concept (ICiC) grant, and a Royal Society Wolfson Research Merit Award.
   PG was supported by the Foundation of Diabetes Research at the
   University Hospital Zurich. This work was also supported by the
   Innovative Medicines Initiative Joint Undertaking under grant agreement
   155005 (IMIDIA), resources of which are composed of financial
   contribution from the European Union's SeventhFramework Programme
   (FP7/2007-2013), and European Federation of Pharmaceutical Industries
   and Associations (EFPIA) companies.
CR Affourtit C, 2011, FREE RADICAL BIO MED, V50, P609, DOI 10.1016/j.freeradbiomed.2010.12.020
   Alcazar O, 2000, BIOCHEM J, V352, P373, DOI 10.1042/0264-6021:3520373
   Aly HF, 2012, EUR REV MED PHARMACO, V16, P66
   Armstrong JS, 2010, FASEB J, V24, P2152, DOI 10.1096/fj.09-143222
   Ashcroft FM, 2012, CELL, V148, P1160, DOI 10.1016/j.cell.2012.02.010
   Avgoustiniatos ES, 1997, ANN NY ACAD SCI, V831, P145
   Avila J, 2005, AM J TRANSPLANT, V5, P2830, DOI 10.1111/j.1600-6143.2005.01109.x
   Banting FG, 2007, INDIAN J MED RES, V125, pA251
   BEGINHEICK N, 1985, DIABETES, V34, P179, DOI 10.2337/diabetes.34.2.179
   Bellomo EA, 2011, J BIOL CHEM, V286, P25778, DOI 10.1074/jbc.M111.246082
   Bensellam M, 2012, MOL CELL ENDOCRINOL, V364, P1, DOI 10.1016/j.mce.2012.08.003
   Bensellam M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0029807
   Bloch K, 2012, HISTOCHEM CELL BIOL, V137, P801, DOI 10.1007/s00418-012-0925-4
   BLUNDELL TL, 1972, DIABETES, V21, P492, DOI 10.2337/diab.21.2.S492
   Bodiga VL, 2015, J INORG BIOCHEM, V153, P49, DOI 10.1016/j.jinorgbio.2015.09.010
   Boesgaard TW, 2008, DIABETOLOGIA, V51, P816, DOI 10.1007/s00125-008-0955-6
   BONNERWEIR S, 1982, DIABETES, V31, P883, DOI 10.2337/diabetes.31.10.883
   Botros N, 2009, AM J MED, V122, P1122, DOI 10.1016/j.amjmed.2009.04.026
   Bottino R, 2004, DIABETES, V53, P2559, DOI 10.2337/diabetes.53.10.2559
   Bottino R, 2002, DIABETES, V51, P2561, DOI 10.2337/diabetes.51.8.2561
   Brand MD, 2005, CELL METAB, V2, P85, DOI 10.1016/j.cmet.2005.06.002
   BRAY TM, 1990, FREE RADICAL BIO MED, V8, P281, DOI 10.1016/0891-5849(90)90076-U
   Brouwers B, 2014, CELL METAB, V20, P979, DOI 10.1016/j.cmet.2014.11.004
   Butler AE, 2003, DIABETES, V52, P102, DOI 10.2337/diabetes.52.1.102
   Cantley J, 2009, J CLIN INVEST, V119, P125, DOI 10.1172/JCI26934
   Carlsson C, 1999, ENDOCRINOLOGY, V140, P3422, DOI 10.1210/en.140.8.3422
   Carocho M, 2013, FOOD CHEM TOXICOL, V51, P15, DOI 10.1016/j.fct.2012.09.021
   Chang I, 2003, DIABETOLOGIA, V46, P1220, DOI 10.1007/s00125-003-1171-z
   Cheng K, 2010, J CLIN INVEST, V120, P2171, DOI 10.1172/JCI35846
   Chimienti F, 2005, BIOMETALS, V18, P313, DOI 10.1007/s10534-005-3687-9
   Cnop M, 2013, J NEUROCHEM, V126, P94, DOI 10.1111/jnc.12216
   Cnop M, 2012, ANN NEUROL, V72, P971, DOI 10.1002/ana.23698
   CORNELIUS JG, 1993, FREE RADICAL BIO MED, V14, P409, DOI 10.1016/0891-5849(93)90090-H
   Cousins RJ, 2006, J BIOL CHEM, V281, P24085, DOI 10.1074/jbc.R600011200
   Del Guerra S, 2005, DIABETES, V54, P727, DOI 10.2337/diabetes.54.3.727
   DENTON RM, 1988, J CARDIOVASC PHARM, V12, pS69
   Di Paola M, 2000, BIOCHEMISTRY-US, V39, P6660, DOI 10.1021/bi9924415
   Dubé A, 2011, BIOCHEM CELL BIOL, V89, P562, DOI [10.1139/o11-063, 10.1139/O11-063]
   Dunn MF, 2005, BIOMETALS, V18, P295, DOI 10.1007/s10534-005-3685-y
   Eide DJ, 2006, BBA-MOL CELL RES, V1763, P711, DOI 10.1016/j.bbamcr.2006.03.005
   Eizirik DL, 1996, HORM METAB RES, V28, P302, DOI 10.1055/s-2007-979799
   EIZIRIK DL, 1994, P NATL ACAD SCI USA, V91, P9253, DOI 10.1073/pnas.91.20.9253
   El Khattabi I, 2013, MOL ENDOCRINOL, V27, P1078, DOI 10.1210/me.2012-1346
   Elsner M, 2011, DIABETES, V60, P200, DOI 10.2337/db09-1401
   Fabbrini E, 2009, OBESITY, V17, P25, DOI 10.1038/oby.2008.494
   Fang Y, 2014, NUTR DIABETES, V4, DOI 10.1038/nutd.2014.28
   FINOCCHIARO G, 1988, NEUROLOGY, V38, P1292, DOI 10.1212/WNL.38.8.1292
   FORMBY B, 1984, DIABETES, V33, P229, DOI 10.2337/diabetes.33.3.229
   FOSTER MC, 1993, BIOPHYS J, V64, P525, DOI 10.1016/S0006-3495(93)81397-3
   Foster M, 2014, J TRACE ELEM MED BIO, V28, P448, DOI 10.1016/j.jtemb.2014.07.012
   Gannon M, 2000, GENESIS, V26, P139, DOI 10.1002/(SICI)1526-968X(200002)26:2<139::AID-GENE12>3.0.CO;2-7
   Gehrmann W, 2015, CELL PHYSIOL BIOCHEM, V36, P852, DOI 10.1159/000430261
   Gerber PA, 2014, DIABETOLOGIA, V57, P1635, DOI 10.1007/s00125-014-3266-0
   Giuliani M, 2005, CELL TRANSPLANT, V14, P67, DOI 10.3727/000000005783983287
   GOLD G, 1984, EXPERIENTIA, V40, P1105, DOI 10.1007/BF01971458
   González M, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0122398
   Grarup N, 2014, DIABETOLOGIA, V57, P1528, DOI 10.1007/s00125-014-3270-4
   Gray JP, 2010, TOXICOL MECH METHOD, V20, P167, DOI 10.3109/15376511003695181
   Greijer AE, 2004, J CLIN PATHOL, V57, P1009, DOI 10.1136/jcp.2003.015032
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Gudz TI, 1997, J BIOL CHEM, V272, P24154, DOI 10.1074/jbc.272.39.24154
   Gunasekara P, 2011, DIABET METAB SYND OB, V4, P53, DOI 10.2147/DMSO.S16691
   Gunton JE, 2005, CELL, V122, P337, DOI 10.1016/j.cell.2005.05.027
   Harmon JS, 2009, ENDOCRINOLOGY, V150, P4855, DOI 10.1210/en.2009-0708
   Harmon JS, 2005, J BIOL CHEM, V280, P11107, DOI 10.1074/jbc.M410345200
   Henquin JC, 2000, DIABETES, V49, P1751, DOI 10.2337/diabetes.49.11.1751
   Hessels AM, 2015, ACS CHEM BIOL, V10, P2126, DOI 10.1021/acschembio.5b00211
   HILL CP, 1991, BIOCHEMISTRY-US, V30, P917, DOI 10.1021/bi00218a006
   Hou N, 2008, ENDOCRINOLOGY, V149, P1654, DOI 10.1210/en.2007-0988
   HUTTON JC, 1983, BIOCHEM J, V210, P297, DOI 10.1042/bj2100297
   Inoguchi T, 2000, DIABETES, V49, P1939, DOI 10.2337/diabetes.49.11.1939
   Ishihara H, 1999, J CLIN INVEST, V104, P1621, DOI 10.1172/JCI7515
   Ivarsson R, 2005, DIABETES, V54, P2132, DOI 10.2337/diabetes.54.7.2132
   Jacob S, 1999, DIABETES, V48, P1113, DOI 10.2337/diabetes.48.5.1113
   Jansson L, 2002, DIABETOLOGIA, V45, P749, DOI 10.1007/s00125-002-0827-4
   JANSSON L, 1994, DIABETES METAB REV, V10, P407, DOI 10.1002/dmr.5610100405
   JENSEN MD, 1989, J CLIN INVEST, V83, P1168, DOI 10.1172/JCI113997
   Jiang BH, 1996, J BIOL CHEM, V271, P17771, DOI 10.1074/jbc.271.30.17771
   Kahn SE, 2014, LANCET, V383, P1068, DOI 10.1016/S0140-6736(13)62154-6
   Kambe T, 2014, CELL MOL LIFE SCI, V71, P3281, DOI 10.1007/s00018-014-1617-0
   Kaneto H, 1999, DIABETES, V48, P2398, DOI 10.2337/diabetes.48.12.2398
   Kaneto H, 2002, J BIOL CHEM, V277, P30010, DOI 10.1074/jbc.M202066200
   Kanoni S, 2011, DIABETES, V60, P2407, DOI 10.2337/db11-0176
   Karpe F, 2011, DIABETES, V60, P2441, DOI 10.2337/db11-0425
   Kawamori D, 2006, J BIOL CHEM, V281, P1091, DOI 10.1074/jbc.M508510200
   Kawamori D, 2003, DIABETES, V52, P2896, DOI 10.2337/diabetes.52.12.2896
   Keane KN, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/181643
   Kim BJ, 2000, DIABETES, V49, P367, DOI 10.2337/diabetes.49.3.367
   Kim HG, 2009, TOXICOL SCI, V112, P435, DOI 10.1093/toxsci/kfp230
   Kim JW, 2006, CELL METAB, V3, P177, DOI 10.1016/j.cmet.2006.02.002
   Kirchhoff K, 2008, DIABETOLOGIA, V51, P597, DOI 10.1007/s00125-008-0926-y
   Kojima I, 2009, KIDNEY INT, V75, P268, DOI 10.1038/ki.2008.488
   Kondo T, 2009, MOL ENDOCRINOL, V23, P1281, DOI 10.1210/me.2008-0482
   Koshkin V, 2003, J BIOL CHEM, V278, P19709, DOI 10.1074/jbc.M209709200
   Krssak M, 1999, DIABETOLOGIA, V42, P113, DOI 10.1007/s001250051123
   Lau J, 2009, CURR OPIN ORGAN TRAN, V14, P688, DOI 10.1097/MOT.0b013e32833239ff
   Lee SC, 2009, J ENDOCRINOL, V203, P33, DOI 10.1677/JOE-09-0117
   Lehmann R, 2015, DIABETES CARE, V38, P752, DOI 10.2337/dc14-1686
   Leloup C, 2009, DIABETES, V58, P673, DOI 10.2337/db07-1056
   Lenaz G, 2001, IUBMB LIFE, V52, P159, DOI 10.1080/15216540152845957
   Lenzen S, 1996, FREE RADICAL BIO MED, V20, P463, DOI 10.1016/0891-5849(96)02051-5
   Lenzen S, 2014, J BIOL CHEM, V289, P12189, DOI 10.1074/jbc.R114.557314
   Li N, 2008, BIOCHEM SOC T, V36, P930, DOI 10.1042/BST0360930
   Li XQ, 2006, DIABETES, V55, P2965, DOI 10.2337/db06-0733
   Li XY, 2004, J BIOL CHEM, V279, P765, DOI 10.1074/jbc.M307907200
   LIFSON N, 1985, AM J PHYSIOL, V249, pE43, DOI 10.1152/ajpendo.1985.249.1.E43
   Liu Z, 2015, J TRACE ELEM MED BIO, V31, P45, DOI 10.1016/j.jtemb.2015.03.003
   Llanos P, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0129238
   Maechler P, 1999, J BIOL CHEM, V274, P27905, DOI 10.1074/jbc.274.39.27905
   Marmolino D, 2011, BRAIN RES REV, V67, P311, DOI 10.1016/j.brainresrev.2011.04.001
   Marselli L, 2014, DIABETOLOGIA, V57, P362, DOI 10.1007/s00125-013-3098-3
   Martens GA, 2005, J BIOL CHEM, V280, P20389, DOI 10.1074/jbc.M411869200
   Matsuoka T, 1997, J CLIN INVEST, V99, P144, DOI 10.1172/JCI119126
   Matsuoka T, 2004, P NATL ACAD SCI USA, V101, P2930, DOI 10.1073/pnas.0306233101
   Matsuoka T, 2015, J BIOL CHEM, V290, P7647, DOI 10.1074/jbc.M114.595579
   Maxwell PH, 1999, NATURE, V399, P271, DOI 10.1038/20459
   McCulloch LJ, 2011, MOL GENET METAB, V104, P648, DOI 10.1016/j.ymgme.2011.08.026
   McGarry JD, 2002, DIABETES, V51, P7, DOI 10.2337/diabetes.51.1.7
   Medvedeva YV, 2009, J NEUROSCI, V29, P1105, DOI 10.1523/JNEUROSCI.4604-08.2009
   MILTHORPE BK, 1977, BIOCHIM BIOPHYS ACTA, V495, P195, DOI 10.1016/0005-2795(77)90376-2
   Mitchell RK, 2016, MOL ENDOCRINOL, V30, P77, DOI 10.1210/me.2015-1227
   Morgan D, 2007, DIABETOLOGIA, V50, P359, DOI 10.1007/s00125-006-0462-6
   Moritz W, 2002, FASEB J, V16, P745, DOI 10.1096/fj.01-0403fje
   Mühlenhoff U, 2002, HUM MOL GENET, V11, P2025, DOI 10.1093/hmg/11.17.2025
   Murphy BJ, 2008, MOL CANCER RES, V6, P483, DOI 10.1158/1541-7786.MCR-07-0341
   Newsholme P, 2007, J PHYSIOL-LONDON, V583, P9, DOI 10.1113/jphysiol.2007.135871
   Newsholme P, 2012, J ENDOCRINOL, V214, P11, DOI 10.1530/JOE-12-0072
   Nicolson TJ, 2009, DIABETES, V58, P2070, DOI 10.2337/db09-0551
   OHLSSON H, 1993, EMBO J, V12, P4251, DOI 10.1002/j.1460-2075.1993.tb06109.x
   Olsson R, 2006, ADV EXP MED BIOL, V578, P263
   Olsson R, 2011, DIABETES, V60, P2350, DOI 10.2337/db09-0490
   Olsson R, 2011, DIABETES, V60, P2068, DOI 10.2337/db09-0877
   Outten CE, 2001, SCIENCE, V292, P2488, DOI 10.1126/science.1060331
   Pacher P, 2007, PHYSIOL REV, V87, P315, DOI 10.1152/physrev.00029.2006
   Padmasekar M, 2013, ENDOCRINOLOGY, V154, P1424, DOI 10.1210/en.2012-1983
   Pan DA, 1997, DIABETES, V46, P983, DOI 10.2337/diabetes.46.6.983
   PANTEN U, 1982, ENDOCRINOLOGY, V111, P1595, DOI 10.1210/endo-111-5-1595
   Papandreou I, 2006, CELL METAB, V3, P187, DOI 10.1016/j.cmet.2006.01.012
   Peppard PE, 2013, AM J EPIDEMIOL, V177, P1006, DOI 10.1093/aje/kws342
   Perry DK, 1997, J BIOL CHEM, V272, P18530, DOI 10.1074/jbc.272.30.18530
   Pi J, 2010, DIABETES OBES METAB, V12, P141, DOI 10.1111/j.1463-1326.2010.01269.x
   Pi JB, 2009, ENDOCRINOLOGY, V150, P3040, DOI 10.1210/en.2008-1642
   Pileggi A, 2001, DIABETES, V50, P1983, DOI 10.2337/diabetes.50.9.1983
   Pong K, 2002, BRAIN RES, V950, P218, DOI 10.1016/S0006-8993(02)03040-8
   Porter AG, 1999, CELL DEATH DIFFER, V6, P99, DOI 10.1038/sj.cdd.4400476
   Prasad AS, 2008, MOL MED, V14, P353, DOI 10.2119/2008-00033.Prasad
   Priou P, 2012, DIABETES CARE, V35, P1902, DOI 10.2337/dc11-2538
   Produit-Zengaffinen N, 2007, DIABETOLOGIA, V50, P84, DOI 10.1007/s00125-006-0499-6
   Proteggente AR, 2002, FREE RADICAL RES, V36, P157, DOI 10.1080/10715760290006475
   Pullen TJ, 2013, DIABETES OBES METAB, V15, P503, DOI 10.1111/dom.12029
   Pullen TJ, 2010, ISLETS, V2, P89, DOI 10.4161/isl.2.2.11025
   Puri S, 2009, DIABETES, V58, P433, DOI 10.2337/db08-0749
   Rashidi A, 2009, MECH AGEING DEV, V130, P216, DOI 10.1016/j.mad.2008.12.007
   Rharass T, 2014, J BIOL CHEM, V289, P27937, DOI 10.1074/jbc.M114.573519
   Ristow M, 2003, J CLIN INVEST, V112, P527, DOI 10.1172/JCI200318107
   Rizzo MA, 2003, J CELL BIOL, V161, P243, DOI 10.1083/jcb.200301063
   Robertson RP, 2007, FEBS LETT, V581, P3743, DOI 10.1016/j.febslet.2007.03.087
   Robertson RP, 2006, CURR OPIN PHARMACOL, V6, P615, DOI 10.1016/j.coph.2006.09.002
   Robson-Doucette CA, 2011, DIABETES, V60, P2710, DOI 10.2337/db11-0132
   Roma LP, 2012, BIOCHEM J, V441, P971, DOI 10.1042/BJ20111770
   Ronksley PE, 2009, THORAX, V64, P834, DOI 10.1136/thx.2009.115105
   Rutter GA, 2014, DIABETIC MED, V31, P1480, DOI 10.1111/dme.12579
   Rutter GA, 2004, DIABETOLOGIA, V47, P1861, DOI 10.1007/s00125-004-1541-1
   RUTTER GA, 1992, BIOCHIM BIOPHYS ACTA, V1175, P107, DOI 10.1016/0167-4889(92)90016-5
   Rutter GA, 2016, P NUTR SOC, V75, P61, DOI 10.1017/S0029665115003237
   Rutter GA, 2015, BIOCHEM J, V466, P203, DOI 10.1042/BJ20141384
   Rutter GA, 2015, DIABETOLOGIA, V58, P31, DOI 10.1007/s00125-014-3405-7
   Ryu JR, 2002, EXP BRAIN RES, V143, P257, DOI 10.1007/s00221-001-0991-7
   Sampson SR, 2010, APOPTOSIS, V15, P1165, DOI 10.1007/s10495-010-0517-5
   Sarre A, 2012, FREE RADICAL BIO MED, V52, P142, DOI 10.1016/j.freeradbiomed.2011.10.437
   Sato Y, 2011, J BIOL CHEM, V286, DOI 10.1074/jbc.M110.194738
   Saxena R, 2007, SCIENCE, V316, P1331, DOI 10.1126/science.1142358
   Schönfeld P, 2007, BBA-BIOENERGETICS, V1767, P1032, DOI 10.1016/j.bbabio.2007.04.005
   Schuit F, 1997, J BIOL CHEM, V272, P18572, DOI 10.1074/jbc.272.30.18572
   Scott DA, 1938, J CLIN INVEST, V17, P725, DOI 10.1172/JCI101000
   SEKINE N, 1994, J BIOL CHEM, V269, P4895
   Semenza GL, 2004, PHYSIOLOGY, V19, P176, DOI 10.1152/physiol.00001.2004
   Semenza GL, 1996, J BIOL CHEM, V271, P32529, DOI 10.1074/jbc.271.51.32529
   Sensi SL, 2003, P NATL ACAD SCI USA, V100, P6157, DOI 10.1073/pnas.1031598100
   Shapiro AMJ, 2006, NEW ENGL J MED, V355, P1318, DOI 10.1056/NEJMoa061267
   Shapiro AMJ, 2000, NEW ENGL J MED, V343, P230, DOI 10.1056/NEJM200007273430401
   Sherwani SI, 2013, SLEEP, V36, P1849, DOI 10.5665/sleep.3214
   Sladek R, 2007, NATURE, V445, P881, DOI 10.1038/nature05616
   Solaini G, 2010, BBA-BIOENERGETICS, V1797, P1171, DOI 10.1016/j.bbabio.2010.02.011
   Sowter HM, 2001, CANCER RES, V61, P6669
   Starkov AA, 2002, J NEUROCHEM, V83, P220, DOI 10.1046/j.1471-4159.2002.01153.x
   Steiner DF, 2011, J BIOL CHEM, V286, P17399, DOI 10.1074/jbc.X111.244764
   Stokes RA, 2013, CELL TRANSPLANT, V22, P253, DOI 10.3727/096368912X647180
   Stork CJ, 2009, J CEREBR BLOOD F MET, V29, P1399, DOI 10.1038/jcbfm.2009.64
   Suksomboon N, 2011, J CLIN PHARM THER, V36, P53, DOI 10.1111/j.1365-2710.2009.01154.x
   Tabák AG, 2009, LANCET, V373, P2215, DOI 10.1016/S0140-6736(09)60619-X
   Takahashi HK, 2014, BIOCHEM J, V460, P411, DOI 10.1042/BJ20131361
   Tanaka Y, 1999, P NATL ACAD SCI USA, V96, P10857, DOI 10.1073/pnas.96.19.10857
   Tarasov AI, 2013, PFLUG ARCH EUR J PHY, V465, P543, DOI 10.1007/s00424-012-1177-9
   Tarasov AI, 2012, CELL CALCIUM, V52, P28, DOI 10.1016/j.ceca.2012.03.003
   Thorens B, 2015, DIABETOLOGIA, V58, P221, DOI 10.1007/s00125-014-3451-1
   Thorrez L, 2011, GENOME RES, V21, P95, DOI 10.1101/gr.109173.110
   Tonooka N, 2007, CLIN TRANSPLANT, V21, P767, DOI 10.1111/j.1399-0012.2007.00736.x
   Turner RC, 1998, DIABETES CARE, V21, pC35, DOI 10.2337/diacare.21.3.C35
   Turrens JF, 2003, J PHYSIOL-LONDON, V552, P335, DOI 10.1113/jphysiol.2003.049478
   VALLEE BL, 1993, PHYSIOL REV, V73, P79, DOI 10.2466/pr0.1993.73.1.79
   Vinkenborg JL, 2009, NAT METHODS, V6, P737, DOI [10.1038/NMETH.1368, 10.1038/nmeth.1368]
   Viswanath K, 2011, BIOMETALS, V24, P171, DOI 10.1007/s10534-010-9371-8
   Wang WM, 2015, CNS NEUROSCI THER, V21, P708, DOI 10.1111/cns.12428
   WELSH N, 1995, MOL MED, V1, P806, DOI 10.1007/BF03401895
   Wicksteed B, 2010, DIABETES, V59, P3090, DOI 10.2337/db10-0624
   Wiseman DA, 2011, J BIOL CHEM, V286, DOI 10.1074/jbc.M110.214031
   Yoshikawa Y, 2011, CHEM PHARM BULL, V59, P972, DOI 10.1248/cpb.59.972
   Yu JH, 2006, ANN NY ACAD SCI, V1090, P292, DOI 10.1196/annals.1378.031
   Zehetner J, 2008, GENE DEV, V22, P3135, DOI 10.1101/gad.496908
   Zhang C, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0049257
   Zhang CY, 2001, CELL, V105, P745, DOI 10.1016/S0092-8674(01)00378-6
   Zhao C, 2001, DIABETES, V50, P361, DOI 10.2337/diabetes.50.2.361
   Zheng X, 2012, CELL DEATH DIS, V3, DOI 10.1038/cddis.2012.66
   Zraika S, 2006, DIABETOLOGIA, V49, P1254, DOI 10.1007/s00125-006-0212-9
NR 215
TC 457
Z9 501
U1 4
U2 126
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD APR
PY 2017
VL 26
IS 10
BP 501
EP +
DI 10.1089/ars.2016.6755
PG 19
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA EP7PX
UT WOS:000397570800002
PM 27225690
OA Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Manente, L
   Lucariello, A
   Costanzo, C
   Viglietti, R
   Parrella, G
   Parrella, R
   Gargiulo, M
   De Luca, A
   Chirianni, A
   Esposito, V
AF Manente, Lucrezia
   Lucariello, Angela
   Costanzo, Carmelina
   Viglietti, Rosaria
   Parrella, Giovanni
   Parrella, Roberto
   Gargiulo, Miriam
   De Luca, Antonio
   Chirianni, Antonio
   Esposito, Vincenzo
TI Suppression of Pre Adipocyte Differentiation and Promotion of Adipocyte
   Death by Anti-HIV Drugs
SO IN VIVO
LA English
DT Article
DE HAART; HIV infection; lipodystrophy; adipocyte differentiation;
   metabolic syndrome; oxidative stress; saquinavir; efavirenz; stavudine;
   antiretroviral therapies
ID PROTEASE INHIBITORS; INSULIN-RESISTANCE; HEME OXYGENASE; STEM-CELL;
   LIPODYSTROPHY; ACCUMULATION; EXPRESSION; STRESS
AB In the present study, we investigated the ability of anti-HIV drugs to interfere with normal cell cycle progression and to induce oxidative stress by perturbing the redox environment. Our results provide evidence that anti-HIV drugs have a differential effect on adipocyte cell cycle and differentiation, being able to modify the response to oxidative stress through an increase of reactive oxygen species (ROS) that compromises the induction of phase-2 and antioxidant enzymes. In detail, saquinavir, efavirenz, and stavudine exert antiadipogenic influences on the model 3T3-L1 cell line, perturbing the oxidative response and inducing of apoptosis. When considered together, the effects of anti-HIV drugs on 3T3-L1 pre adipocytes are distinct but commonly antiadipogenic, thus suggesting another additional possible mechanism by which antiretroviral therapies could contribute to lipoatrophy.
C1 [Manente, Lucrezia; Lucariello, Angela; Costanzo, Carmelina; De Luca, Antonio] Univ Naples 2, Dept Med & Publ Hlth, Sect Human Anat, Naples, Italy.
   [Viglietti, Rosaria; Parrella, Giovanni; Parrella, Roberto; Gargiulo, Miriam; Chirianni, Antonio; Esposito, Vincenzo] Third Div Cotugno Hosp, Naples, Italy.
C3 Universita della Campania Vanvitelli
RP Esposito, V (corresponding author), Terza Div Malattie Infett AO Cotugno, Via G Quagliariello 54, I-80131 Naples, Italy.
EM esposvin@libero.it
RI Lucariello, Angela/AAT-6447-2020; De Luca, Antonio/AAD-9562-2020
OI Esposito, Vincenzo/0000-0003-4696-2363
CR Abraham NG, 2008, PHARMACOL REV, V60, P79, DOI 10.1124/pr.107.07104
   Adachi T, 2009, REDOX REP, V14, P34, DOI 10.1179/135100009X392467
   Carr A, 1998, AIDS, V12, pF51, DOI 10.1097/00002030-199807000-00003
   Dowell P, 2000, J BIOL CHEM, V275, P41325, DOI 10.1074/jbc.M006474200
   Dube MP, 1997, LANCET, V350, P713, DOI 10.1016/S0140-6736(05)63513-1
   Eastone JA, 1997, ANN INTERN MED, V127, P948, DOI 10.7326/0003-4819-127-10-199711150-00017
   Eriksson JW, 2007, FEBS LETT, V581, P3734, DOI 10.1016/j.febslet.2007.06.044
   Esposito V, 2009, DIFFERENTIATION, V77, P148, DOI 10.1016/j.diff.2008.09.016
   Hengel RL, 1998, LANCET, V352, P319
   Miller KD, 1998, LANCET, V351, P871, DOI 10.1016/S0140-6736(97)11518-5
   Mondal Debasis, 2004, Cardiovasc Toxicol, V4, P287, DOI 10.1385/CT:4:3:287
   Otto TC, 2005, CRIT REV BIOCHEM MOL, V40, P229, DOI 10.1080/10409230591008189
   Vanella L, 2010, BONE, V46, P236, DOI 10.1016/j.bone.2009.10.012
   Vincent S, 2004, JAIDS-J ACQ IMM DEF, V37, P1556, DOI 10.1097/00126334-200412150-00003
   Wagener FADTG, 2003, PHARMACOL REV, V55, P551, DOI 10.1124/pr.55.3.5
   Walli R, 1998, AIDS, V12, pF167, DOI 10.1097/00002030-199815000-00001
   Yanovski JA, 1999, J CLIN ENDOCR METAB, V84, P1925, DOI 10.1210/jc.84.6.1925
NR 17
TC 7
Z9 7
U1 0
U2 1
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22,
   ATHENS 19014, GREECE
SN 0258-851X
J9 IN VIVO
JI In Vivo
PD MAR-APR
PY 2012
VL 26
IS 2
BP 287
EP 291
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 899ET
UT WOS:000300798800017
PM 22351671
DA 2025-06-11
ER

PT J
AU McClung, CA
AF McClung, Colleen A.
TI How Might Circadian Rhythms Control Mood? Let Me Count the Ways ...
SO BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Bipolar disorder; circadian rhythms; depression; immune system;
   metabolism; neurogenesis
ID MAJOR DEPRESSION; IMMUNE-SYSTEM; CLOCK GENE; ADULT-RAT; KAPPA-B;
   HIPPOCAMPAL NEUROGENESIS; SUPRACHIASMATIC NUCLEUS; METABOLIC SYNDROME;
   SIGNALING PATHWAY; SOCIAL DEFEAT
AB Mood disorders are serious diseases that affect a large portion of the population. There have been many hypotheses put forth over the years to explain the development of major depression, bipolar disorder, and other mood disorders. These hypotheses include disruptions in monoamine transmission, hypothalamus-pituitary-adrenal axis function, immune function, neurogenesis, mitochondrial dysfunction, and neuropeptide signaling (to name a few). Nearly all people suffering from mood disorders have significant disruptions in circadian rhythms and the sleep/wake cycle. In fact, altered sleep patterns are one of the major diagnostic criteria for these disorders. Moreover, environmental disruptions to circadian rhythms, including shift work, travel across time zones, and irregular social schedules, tend to precipitate or exacerbate mood-related episodes. Recent studies have found that molecular clocks are found throughout the brain and body where they participate in the regulation of most physiological processes, including those thought to be involved in mood regulation. This review will summarize recent data that implicate the circadian system as a vital regulator of a variety of systems that are thought to play a role in the development of mood disorders.
C1 [McClung, Colleen A.] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA 15219 USA.
   [McClung, Colleen A.] Univ Pittsburgh, Sch Med, Translat Neurosci Program, Pittsburgh, PA 15219 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh
RP McClung, CA (corresponding author), Univ Pittsburgh, Sch Med, Dept Psychiat, 450 Technol Dr,Suite 223, Pittsburgh, PA 15219 USA.
EM mcclungca@upmc.edu
RI McClung, Colleen/AAA-5943-2019
FU National Institute of Mental Health [MH082876]; National Institute on
   Drug Abuse [DA023988]; McKnight Foundation; National Alliance for
   Research in Schizophrenia and Affective Disorders
FX Work from our group was funded by National Institute of Mental Health
   (MH082876) and National Institute on Drug Abuse (DA023988), as well as
   the McKnight Foundation and National Alliance for Research in
   Schizophrenia and Affective Disorders.
CR Adamantidis A, 2008, TRENDS ENDOCRIN MET, V19, P362, DOI 10.1016/j.tem.2008.08.007
   Albrecht U, 2012, NEURON, V74, P246, DOI 10.1016/j.neuron.2012.04.006
   Arey R, 2013, MOL PSYCHIAT
   Baglioni C, 2012, CURR PSYCHIAT REP, V14, P511, DOI 10.1007/s11920-012-0308-5
   Bechtold DA, 2010, TRENDS PHARMACOL SCI, V31, P191, DOI 10.1016/j.tips.2010.01.002
   Becker C, 2008, MOL PSYCHIATR, V13, P1079, DOI 10.1038/sj.mp.4002097
   Bellet MM, 2011, COLD SH Q B, V76, P31, DOI 10.1101/sqb.2011.76.010520
   Beynon AL, 2010, CHRONOBIOL INT, V27, P1546, DOI 10.3109/07420528.2010.501927
   Borgs L, 2009, BMC NEUROSCI, V10, DOI 10.1186/1471-2202-10-30
   Buhr ED, 2010, SCIENCE, V330, P379, DOI 10.1126/science.1195262
   Cagampang FR, 2012, BRIT J NUTR, V108, P381, DOI 10.1017/S0007114512002139
   Carvalho LA, 2010, EUR NEUROPSYCHOPHARM, V20, P379, DOI 10.1016/j.euroneuro.2010.02.006
   Charmandari E, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025612
   Chaudhury D, 2013, NATURE, V493, P532, DOI 10.1038/nature11713
   Chenu F, 2013, NEUROPSYCHOPHARMACOL, V38, P275, DOI 10.1038/npp.2012.140
   Clay HB, 2011, INT J DEV NEUROSCI, V29, P311, DOI 10.1016/j.ijdevneu.2010.08.007
   Coque L, 2011, NEUROPSYCHOPHARMACOL, V36, P1478, DOI 10.1038/npp.2011.33
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   Delerive P, 2001, EMBO REP, V2, P42, DOI 10.1093/embo-reports/kve007
   Dockray GJ, 2012, CURR OPIN ENDOCRINOL, V19, P8, DOI 10.1097/MED.0b013e32834eb77d
   Dolci C, 2003, BRAIN RES, V994, P67, DOI 10.1016/j.brainres.2003.09.018
   EHLERS CL, 1988, ARCH GEN PSYCHIAT, V45, P948
   Eisch AJ, 2012, SCIENCE, V338, P72, DOI 10.1126/science.1222941
   Etain B, 2011, EUR NEUROPSYCHOPHARM, V21, pS676, DOI 10.1016/j.euroneuro.2011.07.007
   Eyre H, 2012, PSYCHONEUROENDOCRINO, V37, P1397, DOI 10.1016/j.psyneuen.2012.03.019
   Feillet CA, 2010, J NEUROENDOCRINOL, V22, P620, DOI 10.1111/j.1365-2826.2010.01998.x
   Frodl T, 2013, NEUROBIOL DIS, V52, P24, DOI 10.1016/j.nbd.2012.03.012
   Fulton S, 2006, NEURON, V51, P811, DOI 10.1016/j.neuron.2006.09.006
   Gallagher PJ, 2012, AM J PSYCHIAT, V169, P1065, DOI 10.1176/appi.ajp.2012.11091325
   Gibbs JE, 2012, P NATL ACAD SCI USA, V109, P582, DOI 10.1073/pnas.1106750109
   Gibson EM, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015267
   Gilhooley MJ, 2011, NEUROSCI LETT, V489, P177, DOI 10.1016/j.neulet.2010.12.011
   Guo BY, 2012, FASEB J, V26, P3453, DOI 10.1096/fj.12-205781
   Hampp G, 2008, CURR BIOL, V18, P678, DOI 10.1016/j.cub.2008.04.012
   Hampp Gabriele, 2008, Commun Integr Biol, V1, P1
   Hannibal J, 2010, EUR J NEUROSCI, V32, P1006, DOI 10.1111/j.1460-9568.2010.07385.x
   Hemmerle AM, 2012, EXP NEUROL, V233, P79, DOI 10.1016/j.expneurol.2011.09.035
   Hernando F, 1996, EUR J PHARMACOL, V318, P221, DOI 10.1016/S0014-2999(96)00773-X
   Huang GJ, 2006, BIOL PSYCHIAT, V59, P619, DOI 10.1016/j.biopsych.2005.09.016
   Huang WY, 2011, J CLIN INVEST, V121, P2133, DOI 10.1172/JCI46043
   Imeri L, 2009, NAT REV NEUROSCI, V10, P199, DOI 10.1038/nrn2576
   Jerlhag E, 2007, ADDICT BIOL, V12, P6, DOI 10.1111/j.1369-1600.2006.00041.x
   Kasahara T, 2006, MOL PSYCHIATR, V11, P577, DOI 10.1038/sj.mp.4001824
   Keers R, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038263
   King DP, 1997, CELL, V89, P641, DOI 10.1016/S0092-8674(00)80245-7
   Koo JW, 2010, P NATL ACAD SCI USA, V107, P2669, DOI 10.1073/pnas.0910658107
   Kott J, 2012, NEUROSCI LETT, V515, P177, DOI 10.1016/j.neulet.2012.03.048
   Krishnan V, 2007, CELL, V131, P391, DOI 10.1016/j.cell.2007.09.018
   Kronenberg Sefi, 2011, Expert Rev Clin Pharmacol, V4, P575, DOI 10.1586/ecp.11.47
   Kumar J, 2013, APPETITE, V64, P81, DOI 10.1016/j.appet.2012.12.023
   Kumar S, 2012, GENE DEV, V26, P1224, DOI 10.1101/gad.186338.111
   Lamia KA, 2011, NATURE, V480, P552, DOI 10.1038/nature10700
   Li J, 2010, J CEREBR BLOOD F MET, V30, P480, DOI 10.1038/jcbfm.2009.255
   Libert S, 2011, CELL, V147, P1459, DOI 10.1016/j.cell.2011.10.054
   Lin JD, 2009, MOL ENDOCRINOL, V23, P2, DOI 10.1210/me.2008-0344
   Logan RW, 2012, MOL CELL ENDOCRINOL, V349, P82, DOI 10.1016/j.mce.2011.06.039
   Lucassen EA, 2012, ANN NY ACAD SCI, V1264, P110, DOI 10.1111/j.1749-6632.2012.06655.x
   Lutter M, 2008, NAT NEUROSCI, V11, P752, DOI 10.1038/nn.2139
   Manber R, 2009, CURR PSYCHIAT REP, V11, P437, DOI 10.1007/s11920-009-0066-1
   Manji H, 2012, NAT REV NEUROSCI, V13, P293, DOI 10.1038/nrn3229
   McClung CA, 2005, P NATL ACAD SCI USA, V102, P9377, DOI 10.1073/pnas.0503584102
   McClung CA, 2007, PHARMACOL THERAPEUT, V114, P222, DOI 10.1016/j.pharmthera.2007.02.003
   McClung CA, 2011, EUR NEUROPSYCHOPHARM, V21, pS683, DOI 10.1016/j.euroneuro.2011.07.008
   Meyer JH, 2008, SEMIN NUCL MED, V38, P287, DOI 10.1053/j.semnuclmed.2008.02.007
   Milhiet V, 2011, J PHYSIOL-PARIS, V105, P183, DOI 10.1016/j.jphysparis.2011.07.002
   Miller AH, 2009, BIOL PSYCHIAT, V65, P732, DOI 10.1016/j.biopsych.2008.11.029
   Monje FJ, 2011, J NEUROSCI, V31, P9075, DOI 10.1523/JNEUROSCI.1537-11.2011
   Mukherjee S, 2010, BIOL PSYCHIAT, V68, P503, DOI 10.1016/j.biopsych.2010.04.031
   Müller N, 2006, MOL PSYCHIATR, V11, P680, DOI 10.1038/sj.mp.4001805
   Nakahata Y, 2008, CELL, V134, P329, DOI 10.1016/j.cell.2008.07.002
   Nakahata Y, 2009, SCIENCE, V324, P654, DOI 10.1126/science.1170803
   Narasimamurthy R, 2012, P NATL ACAD SCI USA, V109, P12662, DOI 10.1073/pnas.1209965109
   Nishino S, 2010, ACTA PHYSIOL, V198, P209, DOI 10.1111/j.1748-1716.2009.02012.x
   Ogaya M, 2011, PEPTIDES, V32, P1606, DOI 10.1016/j.peptides.2011.07.001
   Pae CU, 2008, BIOMED PHARMACOTHER, V62, P308, DOI 10.1016/j.biopha.2007.12.005
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pimentel GD, 2013, METABOLISM, V62, P171, DOI 10.1016/j.metabol.2012.07.001
   Pinnock SB, 2008, EUR J NEUROSCI, V27, P2493, DOI 10.1111/j.1460-9568.2008.06250.x
   Prickaerts J, 2006, J NEUROSCI, V26, P9022, DOI 10.1523/JNEUROSCI.5216-05.2006
   Raison CL, 2011, CURR PSYCHIAT REP, V13, P467, DOI 10.1007/s11920-011-0232-0
   Rotzinger S, 2003, J PSYCHIATR NEUROSCI, V28, P171
   Roybal K, 2007, P NATL ACAD SCI USA, V104, P6406, DOI 10.1073/pnas.0609625104
   Rush AJ, 2006, AM J PSYCHIAT, V163, P1905, DOI 10.1176/appi.ajp.163.11.1905
   Schaaf MJM, 2000, MOL BRAIN RES, V75, P342, DOI 10.1016/S0169-328X(99)00314-9
   Son GH, 2011, FRONT NEUROENDOCRIN, V32, P451, DOI 10.1016/j.yfrne.2011.07.003
   Spencer S, 2013, EUR J NEUROSCI, V37, P242, DOI 10.1111/ejn.12010
   Spencer SJ, 2012, BIOL PSYCHIAT, V72, P457, DOI 10.1016/j.biopsych.2012.03.010
   Spengler ML, 2012, P NATL ACAD SCI USA, V109, pE2457, DOI 10.1073/pnas.1206274109
   Tamai SI, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003835
   Turek FW, 2005, SCIENCE, V308, P1043, DOI 10.1126/science.1108750
   Tye KM, 2013, NATURE, V493, P537, DOI 10.1038/nature11740
   Tyring S, 2006, LANCET, V367, P29, DOI 10.1016/S0140-6736(05)67763-X
   Um JH, 2007, J BIOL CHEM, V282, P20794, DOI 10.1074/jbc.C700070200
   Voleti B, 2012, CLIN PHARMACOL THER, V91, P333, DOI 10.1038/clpt.2011.296
   Warner-Schmidt JL, 2011, P NATL ACAD SCI USA, V108, P9262, DOI 10.1073/pnas.1104836108
   Weber M, 2004, NEUROSCI LETT, V358, P17, DOI 10.1016/j.neulet.2003.12.053
   Wirz-Justice A, 2006, INT CLIN PSYCHOPHARM, V21, pS11, DOI 10.1097/01.yic.0000195660.37267.cf
   Wolkowitz OM, 2009, ANN NY ACAD SCI, V1179, P19, DOI 10.1111/j.1749-6632.2009.04980.x
   Zwanzger P, 2012, DEPRESS ANXIETY, V29, P762, DOI 10.1002/da.21919
NR 99
TC 358
Z9 391
U1 1
U2 149
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD AUG 15
PY 2013
VL 74
IS 4
BP 242
EP 249
DI 10.1016/j.biopsych.2013.02.019
PG 8
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 201PY
UT WOS:000323156100004
PM 23558300
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kohen, I
   Lester, PE
   Lam, S
AF Kohen, Izchak
   Lester, Paula E.
   Lam, Sum
TI Antipsychotic treatments for the elderly: efficacy and safety of
   aripiprazole
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Article
DE aripiprazole; antipsychotics; elderly; adverse drug reaction
ID MAJOR DEPRESSIVE DISORDER; LATE-LIFE DEPRESSION; DOUBLE-BLIND;
   ALZHEIMERS-DISEASE; RISK-FACTORS; METABOLIC SYNDROME; INTRAMUSCULAR
   ARIPIPRAZOLE; SCHIZOAFFECTIVE DISORDER; CEREBROVASCULAR EVENTS; BIPOLAR
   DISORDER
AB Delusions, hallucinations and other psychotic symptoms can accompany a number of conditions in late life. As such, elderly patients are commonly prescribed antipsychotic medications for the treatment of psychosis in both acute and chronic conditions. Those conditions include schizophrenia, bipolar disorder, depression and dementia. Elderly patients are at an increased risk of adverse events from antipsychotic medications because of age-related pharmacodynamic and pharmacokinetic changes as well as polypharmacy. Drug selection should be individualized to the patient's previous history of antipsychotic use, current medical conditions, potential drug interactions, and potential side effects of the antipsychotic. Specifically, metabolic side effects should be closely monitored in this population. This paper provides a review of aripiprazole, a newer second generation antipsychotic agent, for its use in a variety of psychiatric disorders in the elderly including schizophrenia, bipolar disorder, dementia, Parkinson's disease and depression. We will review the pharmacokinetics and pharmacodynamics of aripiprazole as well as dosing, diagnostic indications, efficacy studies, and tolerability including its metabolic profile. We will also detail patient focused perspectives including quality of life, patient satisfaction and adherence.
C1 [Kohen, Izchak] N Shore LIJ Hlth Syst, Zucker Hillside Hosp, Div Geriatr Psychiat, Ambulatory Care Pavil, Glen Oaks, NY 11004 USA.
   [Lester, Paula E.] Winthrop Univ Hosp, Div Geriatr Med, Mineola, NY 11501 USA.
   [Lam, Sum] St Johns Univ, Coll Pharm & Allied Hlth Profess, Div Pharm & Geriatr, Queens, NY USA.
C3 Northwell Health; Winthrop University Hospital; Saint John's University
RP Kohen, I (corresponding author), N Shore LIJ Hlth Syst, Zucker Hillside Hosp, Div Geriatr Psychiat, Ambulatory Care Pavil, Room 2106,75-59 263rd St, Glen Oaks, NY 11004 USA.
EM ikohen@nshs.edu
CR ALEXOPOULOS GS, 2004, J CLIN PSYCHIAT S2, V65
   Andrezina R, 2006, PSYCHOPHARMACOLOGY, V188, P281, DOI 10.1007/s00213-006-0541-x
   [Anonymous], INT J NEUROPSYCHOP S
   [Anonymous], QUAL LIF COMP
   Basson BR, 2001, J CLIN PSYCHIAT, V62, P231, DOI 10.4088/JCP.v62n0404
   BELITSKY R, 1993, SCHIZOPHRENIA BULL, V19, P683, DOI 10.1093/schbul/19.4.683
   Berman RM, 2007, J CLIN PSYCHIAT, V68, P843, DOI 10.4088/JCP.v68n0604
   Boulton DW, 2008, CLIN PHARMACOKINET, V47, P475, DOI 10.2165/00003088-200847070-00004
   Briesacher BA, 2005, ARCH INTERN MED, V165, P1280, DOI 10.1001/archinte.165.11.1280
   Bruce ML, 2004, JAMA-J AM MED ASSOC, V291, P1081, DOI 10.1001/jama.291.9.1081
   BURNS A, 1990, BRIT J PSYCHIAT, V157, P86, DOI 10.1192/bjp.157.1.86
   Burris KD, 2002, J PHARMACOL EXP THER, V302, P381, DOI 10.1124/jpet.102.033175
   Casey Daniel E, 2005, Am J Med, V118 Suppl 2, p15S
   Casey DE, 2003, PSYCHOPHARMACOLOGY, V166, P391, DOI 10.1007/s00213-002-1344-3
   CASTLE DJ, 1993, SCHIZOPHRENIA BULL, V19, P691, DOI 10.1093/schbul/19.4.691
   Citrome L, 2007, J CLIN PSYCHOPHARM, V27, P279, DOI 10.1097/jcp.0b013e318056f309
   Coley KC, 2009, J PSYCHIATR PRACT, V15, P150, DOI 10.1097/01.pra.0000348369.19172.ba
   Copeland JRM, 1998, SCHIZOPHRENIA BULL, V24, P153, DOI 10.1093/oxfordjournals.schbul.a033307
   Corriss DJ, 1999, PSYCHIAT RES, V89, P269, DOI 10.1016/S0165-1781(99)00111-0
   Crismon LM., 2008, Pharmacotherapy: A Pathophysiologic Approach, V7th ed, P1099
   Cummings J.L., 1992, Dementia: A clinical approach
   Cutler AJ, 2006, CNS SPECTRUMS, V11, P691, DOI 10.1017/S1092852900014784
   DAVIDSON M, 1995, AM J PSYCHIAT, V152, P197
   De Deyn P, 2005, J CLIN PSYCHOPHARM, V25, P463, DOI 10.1097/01.jcp.0000178415.22309.8f
   De Hert M, 2007, SCHIZOPHRENIA BULL, V33, P823, DOI 10.1093/schbul/sbl037
   DeLeon A, 2004, CLIN THER, V26, P649, DOI 10.1016/S0149-2918(04)90066-5
   Dewa CS, 2002, CLIN THER, V24, P1466, DOI 10.1016/S0149-2918(02)80050-9
   El-Sayeh HG, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004578.pub3
   *FDA, FDA PUBL HLTH ADV
   Freedman R, 2003, NEW ENGL J MED, V349, P1738, DOI 10.1056/NEJMra035458
   Friedman J, 1999, NEW ENGL J MED, V340, P757
   Friedman JH, 2000, MOVEMENT DISORD, V15, P201, DOI 10.1002/1531-8257(200003)15:2<201::AID-MDS1001>3.0.CO;2-D
   Friedman JH, 2006, MOVEMENT DISORD, V21, P2078, DOI 10.1002/mds.21091
   Gildengers AG, 2005, AM J GERIAT PSYCHIAT, V13, P319
   GREEN JH, 1988, HOSP COMMUNITY PSYCH, V39, P963
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Hanssens L, 2008, BMC PSYCHIATRY, V8, DOI 10.1186/1471-244X-8-95
   Heaton RK, 2001, ARCH GEN PSYCHIAT, V58, P24, DOI 10.1001/archpsyc.58.1.24
   Hildrum B, 2007, BMC PUBLIC HEALTH, V7, DOI 10.1186/1471-2458-7-220
   Hirschfeld RMA, 2003, J CLIN PSYCHIAT, V64, P53, DOI 10.4088/JCP.v64n0111
   Howard R, 2000, AM J PSYCHIAT, V157, P172, DOI 10.1176/appi.ajp.157.2.172
   Howard RJ, 1997, BRIT J PSYCHIAT, V170, P511, DOI 10.1192/bjp.170.6.511
   Huber G, 1997, SCHIZOPHR RES, V28, P177, DOI 10.1016/S0920-9964(97)00113-8
   Jeste DV, 2008, NEUROPSYCHOPHARMACOL, V33, P957, DOI 10.1038/sj.npp.1301492
   Jeste DV, 2000, AM J GERIAT PSYCHIAT, V8, P29, DOI 10.1097/00019442-200002000-00004
   Jeste DV, 2004, TXB GERIATRIC PSYCHI, P269
   Kane JM, 2002, J CLIN PSYCHIAT, V63, P763, DOI 10.4088/JCP.v63n0903
   Kasper S, 2003, PSYCHONEUROENDOCRINO, V28, P27, DOI 10.1016/S0306-4530(02)00115-4
   Kasper S, 2003, INT J NEUROPSYCHOPH, V6, P325, DOI 10.1017/S1461145703003651
   KAY SR, 1987, SCHIZOPHRENIA BULL, V13, P261, DOI 10.1093/schbul/13.2.261
   Keck PE, 2006, J CLIN PSYCHIAT, V67, P626, DOI 10.4088/JCP.v67n0414
   Keck PE, 2003, AM J PSYCHIAT, V160, P1651, DOI 10.1176/appi.ajp.160.9.1651
   KEITH SJ, 1991, SCHIZOPHRENIC DISORD
   KELLY GR, 1990, MED CARE, V28, P1181, DOI 10.1097/00005650-199012000-00006
   Kern RS, 2006, PSYCHOPHARMACOLOGY, V187, P312, DOI 10.1007/s00213-006-0428-x
   Lopez OL, 1999, ARCH NEUROL-CHICAGO, V56, P1266, DOI 10.1001/archneur.56.10.1266
   Ltd OPC, 2009, PROD INF ABILIFY R O
   Lublin H, 2005, INT CLIN PSYCHOPHARM, V20, P183, DOI 10.1097/00004850-200507000-00001
   Madhusoodanan S, 2004, CNS SPECTRUMS, V9, P862, DOI 10.1017/S1092852900002273
   Madhusoodanan S, 2008, CLIN INTERV AGING, V3, P491, DOI 10.2147/CIA.S3351
   Madhusoodanan S, 2007, CNS DRUGS, V21, P101, DOI 10.2165/00023210-200721020-00002
   Magura S, 2002, PSYCHIAT SERV, V53, P310, DOI 10.1176/appi.ps.53.3.310
   Mallikaarjun S, 2008, CLIN PHARMACOKINET, V47, P533, DOI 10.2165/00003088-200847080-00003
   Marder SR, 2003, SCHIZOPHR RES, V61, P123, DOI 10.1016/S0920-9964(03)00050-1
   McEvoy JP, 2007, J PSYCHIATR RES, V41, P895, DOI 10.1016/j.jpsychires.2007.05.002
   McGavin JK, 2002, CNS DRUGS, V16, P779, DOI 10.2165/00023210-200216110-00008
   McQuade RD, 2004, J CLIN PSYCHIAT, V65, P47
   Mintzer JE, 2007, AM J GERIAT PSYCHIAT, V15, P918, DOI 10.1097/JGP.0b013e3181557b47
   Mortimer AM, 2007, BRIT J PSYCHIAT, V191, pS7, DOI 10.1192/bjp.191.50.s7
   Newcomer JW, 2008, J CLIN PSYCHIAT, V69, P1046, DOI 10.4088/JCP.v69n0702
   Olfson M, 2000, PSYCHIATR SERV, V51, P216, DOI 10.1176/appi.ps.51.2.216
   Östling S, 2002, ARCH GEN PSYCHIAT, V59, P53, DOI 10.1001/archpsyc.59.1.53
   Palmer BW, 2001, HARVARD REV PSYCHIAT, V9, P51, DOI 10.1093/hrp/9.2.51
   Papakostas GI, 2007, J CLIN PSYCHIAT, V68, P826, DOI 10.4088/JCP.v68n0602
   Park S, 2008, J GERONTOL A-BIOL, V63, P1119, DOI 10.1093/gerona/63.10.1119
   Paulsen JS, 2000, NEUROLOGY, V54, P1965, DOI 10.1212/WNL.54.10.1965
   PETRIE JL, 1997, EUR NEUROPSYCHOPHA S, V7, pS227
   Pigott TA, 2003, J CLIN PSYCHIAT, V64, P1048, DOI 10.4088/JCP.v64n0910
   Potkin SG, 2003, ARCH GEN PSYCHIAT, V60, P681, DOI 10.1001/archpsyc.60.7.681
   RAM R, 1992, SCHIZOPHRENIA BULL, V18, P185, DOI 10.1093/schbul/18.2.185
   Ropacki SA, 2005, AM J PSYCHIAT, V162, P2022, DOI 10.1176/appi.ajp.162.11.2022
   Rutherford B, 2007, INT J GERIATR PSYCH, V22, P986, DOI 10.1002/gps.1775
   Sachs G, 2006, J PSYCHOPHARMACOL, V20, P536, DOI 10.1177/0269881106059693
   Sajatovic M, 2008, J CLIN PSYCHIAT, V69, P41, DOI 10.4088/JCP.v69n0106
   Schoen MD, 2001, PHARMACOTHERAPY, V21, P1455, DOI 10.1592/phco.21.20.1455.34473
   Sheffrin M, 2009, J CLIN PSYCHIAT, V70, P208, DOI 10.4088/JCP.07m03805
   Solomon D K, 1998, J Am Pharm Assoc (Wash), V38, P574
   Stewart KJ, 2005, AM J PREV MED, V28, P9, DOI 10.1016/j.amepre.2004.09.006
   Street JS, 2000, ARCH GEN PSYCHIAT, V57, P968, DOI 10.1001/archpsyc.57.10.968
   Streim JE, 2004, 157 AM PSYCH ASS M
   Sun SX, 2007, CURR MED RES OPIN, V23, P2305, DOI 10.1185/030079907X226050
   Taylor D, 2008, EUR PSYCHIAT, V23, P336, DOI 10.1016/j.eurpsy.2008.03.006
   Tran-Johnson TK, 2007, J CLIN PSYCHIAT, V68, P111, DOI 10.4088/JCP.v68n0115
   Unützer J, 2002, JAMA-J AM MED ASSOC, V288, P2836, DOI 10.1001/jama.288.22.2836
   Waade RB, 2009, THER DRUG MONIT, V31, P233, DOI 10.1097/FTD.0b013e3181956726
   WEIDEN PJ, 1995, SCHIZOPHRENIA BULL, V21, P419, DOI 10.1093/schbul/21.3.419
   Wooltorton E, 2002, CAN MED ASSOC J, V167, P1269
   Wooltorton E, 2004, CAN MED ASSOC J, V170, P1395, DOI 10.1503/cmaj.1040539
   Worrel JA, 2000, AM J HEALTH-SYST PH, V57, P238, DOI 10.1093/ajhp/57.3.238
   YOUNG RC, 1978, BRIT J PSYCHIAT, V133, P429, DOI 10.1192/bjp.133.5.429
NR 100
TC 33
Z9 38
U1 0
U2 11
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2010
VL 6
BP 47
EP 58
PG 12
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 821CV
UT WOS:000294953300006
PM 20361061
DA 2025-06-11
ER

PT J
AU Gherghina, ME
   Peride, I
   Tiglis, M
   Neagu, TP
   Niculae, A
   Checherita, IA
AF Gherghina, Mihai-Emil
   Peride, Ileana
   Tiglis, Mirela
   Neagu, Tiberiu Paul
   Niculae, Andrei
   Checherita, Ionel Alexandru
TI Uric Acid and Oxidative Stress-Relationship with Cardiovascular,
   Metabolic, and Renal Impairment
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE uric acid; cardiovascular risk; oxidative stress; chronic kidney
   disease; outcome
ID CHRONIC KIDNEY-DISEASE; C-REACTIVE PROTEIN; SERUM URATE; LOWERING
   THERAPY; ASYMPTOMATIC HYPERURICEMIA; MULTIPLE-SCLEROSIS;
   CELL-PROLIFERATION; GOUT; RISK; PROGRESSION
AB Background: The connection between uric acid (UA) and renal impairment is well known due to the urate capacity to precipitate within the tubules or extra-renal system. Emerging studies allege a new hypothesis concerning UA and renal impairment involving a pro-inflammatory status, endothelial dysfunction, and excessive activation of renin-angiotensin-aldosterone system (RAAS). Additionally, hyperuricemia associated with oxidative stress is incriminated in DNA damage, oxidations, inflammatory cytokine production, and even cell apoptosis. There is also increasing evidence regarding the association of hyperuricemia with chronic kidney disease (CKD), cardiovascular disease, and metabolic syndrome or diabetes mellitus. Conclusions: Important aspects need to be clarified regarding hyperuricemia predisposition to oxidative stress and its effects in order to initiate the proper treatment to determine the optimal maintenance of UA level, improving patients' long-term prognosis and their quality of life.
C1 [Gherghina, Mihai-Emil; Peride, Ileana; Niculae, Andrei; Checherita, Ionel Alexandru] Carol Davila Univ Med & Pharm Bucharest, Dept Nephrol, Bucharest 020021, Romania.
   [Tiglis, Mirela] Carol Davila Univ Med & Pharm Bucharest, Dept Anesthesiol & Intens Care, Bucharest 020021, Romania.
   [Neagu, Tiberiu Paul] Carol Davila Univ Med & Pharm Bucharest, Dept Plast Surg & Reconstruct Microsurg, Bucharest 020021, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy; Carol Davila University of Medicine & Pharmacy
RP Peride, I (corresponding author), Carol Davila Univ Med & Pharm Bucharest, Dept Nephrol, Bucharest 020021, Romania.
EM gherghina_mihai92@yahoo.com; ileana_peride@yahoo.com;
   mirelatiglis@gmail.com; dr.neagupaul@gmail.com; niculaeandrei@yahoo.com;
   al.checherita@gmail.com
RI peride, ileana/G-6503-2014; Tiglis, Mirela/AFP-1980-2022; Checherita,
   Ionel/AAX-6544-2021
OI Peride, Ileana/0000-0002-4912-6590; Neagu, Tiberiu
   Paul/0000-0002-4319-1965; Tiglis, Mirela/0000-0003-3542-3217;
   Checherita, Ionel Alexandru/0000-0002-9741-5530
CR Adomako E, 2020, SEMIN NEPHROL, V40, P564, DOI 10.1016/j.semnephrol.2020.12.003
   Agarwal V, 2013, J CLIN HYPERTENS, V15, P435, DOI 10.1111/j.1751-7176.2012.00701.x
   Aktas G, 2022, POSTGRAD MED, V134, P297, DOI 10.1080/00325481.2022.2039007
   Baer PC, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21020391
   Bailey CJ, 2019, DIABETES OBES METAB, V21, P1291, DOI 10.1111/dom.13670
   Bolayir A, 2021, BRATISL MED J, V122, P357, DOI 10.4149/BLL_2021_060
   Borghi C, 2015, J HYPERTENS, V33, P1729, DOI 10.1097/HJH.0000000000000701
   Bose B, 2014, NEPHROL DIAL TRANSPL, V29, P406, DOI 10.1093/ndt/gft378
   Bove M, 2017, CURR HYPERTENS REP, V19, DOI 10.1007/s11906-017-0793-3
   Bove M, 2017, VASC HEALTH RISK MAN, V13, P23, DOI 10.2147/VHRM.S115080
   Caliceti C, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040395
   Carbone A, 2018, MINERVA UROL NEFROL, V70, P393, DOI 10.23736/S0393-2249.18.03113-2
   Chen Q, 2020, CLIN J AM SOC NEPHRO, V15, P1576, DOI 10.2215/CJN.05190420
   Chino Y, 2022, J CLIN PHARMACOL, V62, P366, DOI 10.1002/jcph.1970
   Choi HK, 2005, ANN INTERN MED, V143, P499, DOI 10.7326/0003-4819-143-7-200510040-00009
   Choi HK, 2007, ARTHRIT RHEUM-ARTHR, V57, P816, DOI 10.1002/art.22762
   Chonchol M, 2007, AM J KIDNEY DIS, V50, P239, DOI 10.1053/j.ajkd.2007.05.013
   Corry DB, 2008, J HYPERTENS, V26, P269, DOI 10.1097/HJH.0b013e3282f240bf
   Dekkers CCJ, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-0992-6
   Dekkers CCJ, 2018, DIABETES OBES METAB, V20, P1988, DOI 10.1111/dom.13301
   Dinour D, 2010, J AM SOC NEPHROL, V21, P64, DOI 10.1681/ASN.2009040406
   Dogru S, 2022, J RECEPT SIG TRANSD, V42, P293, DOI 10.1080/10799893.2021.1931320
   Egan BM, 2000, AM J MED SCI, V320, P233, DOI 10.1097/00000441-200010000-00002
   Ejaz AA, 2020, SEMIN NEPHROL, V40, P574, DOI 10.1016/j.semnephrol.2020.12.004
   Ejaz AA, 2019, NEPHRON, V142, P275, DOI 10.1159/000499939
   El Ridi R, 2017, J ADV RES, V8, P487, DOI 10.1016/j.jare.2017.03.003
   FANELLI G M JR, 1970, American Journal of Physiology, V218, P627
   FitzGerald JD, 2020, ARTHRITIS RHEUMATOL, V72, P879, DOI 10.1002/art.41247
   Flisinski M, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23010203
   Franco Álvaro de Oliveira, 2019, Braz. J. Nephrol., V41, P103, DOI [10.1590/2175-8239-JBN-2018-0033, 10.1590/2175-8239-jbn-2018-0033]
   Furuhashi M, 2020, AM J PHYSIOL-ENDOC M, V319, pE827, DOI 10.1152/ajpendo.00378.2020
   GALVAN AQ, 1995, AM J PHYSIOL-ENDOC M, V268, pE1, DOI 10.1152/ajpendo.1995.268.1.E1
   Gaubert M, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21114066
   GERSHON SL, 1974, J LAB CLIN MED, V84, P179
   Giandalia A, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22115808
   Goicoechea M, 2010, CLIN J AM SOC NEPHRO, V5, P1388, DOI 10.2215/CJN.01580210
   GOLDFINGER S, 1965, NEW ENGL J MED, V272, P351, DOI 10.1056/NEJM196502182720705
   Golmohammadi S, 2017, IRAN J KIDNEY DIS, V11, P286
   Grayson PC, 2011, ARTHRIT CARE RES, V63, P102, DOI 10.1002/acr.20344
   Gruszka K., 2022, BLOOD PRESS MONIT
   Guthikonda S, 2003, CIRCULATION, V107, P416, DOI 10.1161/01.CIR.0000046448.26751.58
   Hanna RM, 2020, BLOOD PURIFICAT, V49, P202, DOI 10.1159/000504240
   Heda R, 2021, WORLD J GASTROENTERO, V27, P1864, DOI 10.3748/wjg.v27.i17.1864
   Hsu YSO, 2020, CLIN PHARMACOL THER, V107, P1159, DOI 10.1002/cpt.1697
   Hu JH, 2021, REPROD BIOL ENDOCRIN, V19, DOI 10.1186/s12958-021-00748-7
   Hughes K, 2014, KIDNEY INT, V85, P344, DOI 10.1038/ki.2013.353
   Hui JY, 2012, ARTHRITIS RES THER, V14, DOI 10.1186/ar3769
   Isaka Y, 2016, NEPHROL DIAL TRANSPL, V31, P890, DOI 10.1093/ndt/gfv024
   Jakse B, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081736
   Jin M, 2012, FRONT BIOSCI-LANDMRK, V17, P656, DOI 10.2741/3950
   Johnson RJ, 2018, AM J KIDNEY DIS, V71, P851, DOI 10.1053/j.ajkd.2017.12.009
   Joosten LAB, 2020, NAT REV RHEUMATOL, V16, P75, DOI 10.1038/s41584-019-0334-3
   Jutabha P, 2010, J BIOL CHEM, V285, P35123, DOI 10.1074/jbc.M110.121301
   Kang DH, 2005, J AM SOC NEPHROL, V16, P3553, DOI 10.1681/ASN.2005050572
   Keenan RT, 2020, SEMIN ARTHRITIS RHEU, V50, pS2, DOI 10.1016/j.semarthrit.2020.04.007
   Kielstein JT, 2020, CURR HYPERTENS REP, V22, DOI 10.1007/s11906-020-01116-3
   Kim KM, 2009, J CHROMATOGR B, V877, P2032, DOI 10.1016/j.jchromb.2009.05.037
   Kimura Y, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222212394
   Kleber ME, 2015, J AM SOC NEPHROL, V26, P2831, DOI 10.1681/ASN.2014070660
   Köttgen A, 2013, NAT GENET, V45, P145, DOI 10.1038/ng.2500
   Kuriyama S, 2020, CLIN EXP NEPHROL, V24, P1, DOI 10.1007/s10157-019-01811-9
   Lee JW, 2019, INT UROL NEPHROL, V51, P467, DOI 10.1007/s11255-018-2051-2
   Li X, 2017, BMJ-BRIT MED J, V357, DOI 10.1136/bmj.j2376
   Limirio LS, 2021, J RENAL NUTR, V31, P637, DOI 10.1053/j.jrn.2020.11.009
   Lin TC, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000016311
   Liu XM, 2018, RENAL FAILURE, V40, P289, DOI 10.1080/0886022X.2018.1456463
   Lu N, 2016, ANN RHEUM DIS, V75, P547, DOI 10.1136/annrheumdis-2014-206917
   Luo QM, 2019, BMC NEPHROL, V20, DOI 10.1186/s12882-018-1143-7
   Lv Q, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0056864
   Ma J, 2022, MEDICINE, V101, DOI 10.1097/MD.0000000000028442
   Maesaka JK, 1998, AM J KIDNEY DIS, V32, P917, DOI 10.1016/S0272-6386(98)70067-8
   Mahaffey KW, 2019, DIABETOLOGIA, V62, pS340
   Maiuolo J, 2016, INT J CARDIOL, V213, P8, DOI 10.1016/j.ijcard.2015.08.109
   Major TJ, 2018, BMJ-BRIT MED J, V363, DOI 10.1136/bmj.k3951
   Mallamaci F, 2014, J HYPERTENS, V32, P1621, DOI 10.1097/HJH.0000000000000224
   Mandal AK, 2015, ANNU REV PHYSIOL, V77, P323, DOI 10.1146/annurev-physiol-021113-170343
   Mauer M, 2020, J NEPHROL, V33, P995, DOI 10.1007/s40620-020-00796-z
   Miao Y, 2011, HYPERTENSION, V58, P2, DOI 10.1161/HYPERTENSIONAHA.111.171488
   Miller SG, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21010088
   Moccia M, 2015, J NEUROL, V262, P961, DOI 10.1007/s00415-015-7666-y
   Moriwaki Y, 2002, METABOLISM, V51, P893, DOI 10.1053/meta.2002.32801
   Nakagawa T, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.694457
   NAKASHIMA M, 1992, EUR J CLIN PHARMACOL, V42, P333
   Nigam SK, 2018, CURR OPIN NEPHROL HY, V27, P305, DOI 10.1097/MNH.0000000000000427
   Niu SW, 2022, J PERS MED, V12, DOI 10.3390/jpm12010028
   Novak S, 2007, CURR MED RES OPIN, V23, P623, DOI 10.1185/030079906X167651
   Oikonen M, 2012, ATHEROSCLEROSIS, V223, P497, DOI 10.1016/j.atherosclerosis.2012.05.036
   Palmer TM, 2013, BMJ-BRIT MED J, V347, DOI 10.1136/bmj.f4262
   Park JH, 2020, KOREAN J INTERN MED, V35, P1291, DOI 10.3904/kjim.2020.410
   Petreski T, 2020, RENAL FAILURE, V42, P978, DOI 10.1080/0886022X.2020.1822185
   Rana P, 2021, ACTA PHARM SIN B, V11, P3857, DOI 10.1016/j.apsb.2021.05.028
   Rapa SF, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21010263
   Roch-Ramel F, 1999, NEWS PHYSIOL SCI, V14, P80
   Roumeliotis S, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081911
   Ruggiero C, 2007, AM J CARDIOL, V100, P115, DOI 10.1016/j.amjcard.2007.02.065
   Sampson AL, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009460.pub2
   Sedaghat S, 2014, HYPERTENSION, V64, P1061, DOI 10.1161/HYPERTENSIONAHA.114.03757
   Shaffner J, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.749010
   Shen CH, 2013, CAN J NEUROL SCI, V40, P73, DOI 10.1017/S0317167100012981
   Shi YJ, 2012, KIDNEY BLOOD PRESS R, V35, P153, DOI 10.1159/000331453
   Singh JA, 2018, ANN RHEUM DIS, V77, P317, DOI [10.1136/annrheumdis-2017-211975, 10.1136/annrheumdis-2017-211418]
   Su HY, 2020, BIOMED RES INT, V2020, DOI 10.1155/2020/5817348
   Su XL, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0187550
   Takata T, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22094374
   Tsai CW, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0170393
   Uetake D, 2010, INTERNAL MED, V49, P89, DOI 10.2169/internalmedicine.49.2597
   van Bommel EJM, 2017, CLIN J AM SOC NEPHRO, V12, P700, DOI 10.2215/CJN.06080616
   Vanholder R, 2018, TOXINS, V10, DOI 10.3390/toxins10010033
   Viazzi F, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0176058
   Viggiano D, 2018, KIDNEY BLOOD PRESS R, V43, P606, DOI 10.1159/000489145
   Waheed Y, 2021, KOREAN J INTERN MED, V36, P1281, DOI 10.3904/kjim.2020.340
   Wang J, 2014, PLOS ONE, V9, DOI [10.1371/journal.pone.0105125, 10.1371/journal.pone.0114259]
   Wong K, 2016, BBA-MOL CELL RES, V1863, P19, DOI 10.1016/j.bbamcr.2015.10.002
   Woodward OM, 2013, P NATL ACAD SCI USA, V110, P5223, DOI 10.1073/pnas.1214530110
   Woodward OM, 2009, P NATL ACAD SCI USA, V106, P10338, DOI 10.1073/pnas.0901249106
   Wu W, 2011, MOL PHARMACOL, V79, P795, DOI 10.1124/mol.110.070607
   Xin P, 2021, Zhonghua Liu Xing Bing Xue Za Zhi, V42, P1076, DOI 10.3760/cma.j.cn112338-20200806-01029
   Yamanaka H, 2011, NUCLEOS NUCLEOT NUCL, V30, P1018, DOI 10.1080/15257770.2011.596496
   Yang T, 2016, RHEUMATOL INT, V36, P561, DOI 10.1007/s00296-016-3429-z
   Zanoli L, 2019, J AM SOC NEPHROL, V30, P918, DOI 10.1681/ASN.2019020117
   Zhang X, 2019, INT UROL NEPHROL, V51, P2273, DOI 10.1007/s11255-019-02318-8
   Zhou Y, 2020, EXP THER MED, V20, P1682, DOI 10.3892/etm.2020.8812
   Zhou Y, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000013108
   Zhu YY, 2012, AM J MED, V125, P679, DOI 10.1016/j.amjmed.2011.09.033
NR 124
TC 210
Z9 225
U1 36
U2 123
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2022
VL 23
IS 6
AR 3188
DI 10.3390/ijms23063188
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 0C4GZ
UT WOS:000775275000001
PM 35328614
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Seo, HA
   Lee, IK
AF Seo, Hyun-Ae
   Lee, In-Kyu
TI The Role of Nrf2: Adipocyte Differentiation, Obesity, and Insulin
   Resistance
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID ARYL-HYDROCARBON RECEPTOR; DIET-INDUCED OBESITY; OXIDATIVE STRESS;
   METABOLIC SYNDROME; ADIPOSE-TISSUE; ENERGY-METABOLISM; CARNOSIC ACID;
   3T3-L1 CELLS; IN-VITRO; INDUCTION
AB Metabolic diseases, such as type 2 diabetes and obesity, are increasing globally, and much work has been performed to elucidate the regulatory mechanisms of these diseases. Nuclear factor E2-related factor 2 (Nrf2) is a basic leucine zipper transcription factor that serves as a primary cellular defense against the cytotoxic effects of oxidative stress. Recent studies have proposed a close relationship between oxidative stress and energy metabolism-associated disease. The Nrf2 pathway, as a master regulator of cellular defense against oxidative stress, has emerged as a critical target of energy metabolism; however, its effects are controversial. This review examines the current state of research on the role of Nrf2 on energy metabolism, specifically with respect to its participation in adipocyte differentiation, obesity, and insulin resistance, and discusses the possibility of using Nrf2 as a therapeutic target in the clinic.
C1 [Seo, Hyun-Ae] Daegu Fatima Hosp, Dept Internal Med, Taegu 701600, South Korea.
   [Seo, Hyun-Ae; Lee, In-Kyu] Kyungpook Natl Univ, Sch Med, Dept Internal Med, Res Inst Aging & Metab,WCU Program, Taegu 700721, South Korea.
   [Seo, Hyun-Ae; Lee, In-Kyu] Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Res Inst Aging & Metab,WCU Program, Taegu 700721, South Korea.
C3 Daegu Fatima Hospital; Kyungpook National University (KNU); Kyungpook
   National University (KNU)
RP Lee, IK (corresponding author), Kyungpook Natl Univ, Sch Med, Dept Internal Med, Res Inst Aging & Metab,WCU Program, 50 Samduk-2Ga, Taegu 700721, South Korea.
EM leei@knu.ac.kr
RI Lee, In-Kyu/AAR-6374-2021
FU National Research Foundation [2012R1A2A1A03670452]; Ministry of
   Education, Science, and Technology; Korea Health Technology RD Project;
   Ministry of Health and Welfare, Republic of Korea [A111345]; Kyungpook
   National University Research Fund
FX This work was supported by Grants from the National Research Foundation
   (2012R1A2A1A03670452 and WCU program R32-10064) funded by the Ministry
   of Education, Science, and Technology and a Grant of the Korea Health
   Technology R&D Project, Ministry of Health and Welfare, Republic of
   Korea (A111345), and supported by Kyungpook National University Research
   Fund, 2012.
CR Aleksunes LM, 2010, J PHARMACOL EXP THER, V333, P140, DOI 10.1124/jpet.109.162271
   Alexander DL, 1998, J CELL SCI, V111, P3311
   Bagul PK, 2012, PHARMACOL RES, V66, P260, DOI 10.1016/j.phrs.2012.05.003
   Balogun E, 2003, BIOCHEM J, V371, P887, DOI 10.1042/BJ20021619
   Bloch-Damti A, 2005, ANTIOXID REDOX SIGN, V7, P1553, DOI 10.1089/ars.2005.7.1553
   Chartoumpekis DV, 2011, DIABETES, V60, P2465, DOI 10.2337/db11-0112
   Cheng AS, 2012, J AGR FOOD CHEM, V60, P9180, DOI 10.1021/jf302831d
   Collins AR, 2012, ARTERIOSCL THROM VAS, V32, P2839, DOI 10.1161/ATVBAHA.112.300345
   de Ferranti S, 2008, CLIN CHEM, V54, P945, DOI 10.1373/clinchem.2007.100156
   Findeisen HM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0018532
   Frisard M, 2006, ENDOCRINE, V29, P27, DOI 10.1385/ENDO:29:1:27
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gavin JR, 2000, DIABETES CARE, V23, pS4
   Gregoire FM, 1998, PHYSIOL REV, V78, P783, DOI 10.1152/physrev.1998.78.3.783
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   He HJ, 2012, WORLD J DIABETES, V3, P94, DOI 10.4239/wjd.v3.i5.94
   Hou YY, 2012, FREE RADICAL BIO MED, V52, P462, DOI 10.1016/j.freeradbiomed.2011.10.453
   Ishii T, 2000, J BIOL CHEM, V275, P16023, DOI 10.1074/jbc.275.21.16023
   Itoh K, 1999, GENE DEV, V13, P76, DOI 10.1101/gad.13.1.76
   Itoh K, 1997, BIOCHEM BIOPH RES CO, V236, P313, DOI 10.1006/bbrc.1997.6943
   Kaspar JW, 2009, FREE RADICAL BIO MED, V47, P1304, DOI 10.1016/j.freeradbiomed.2009.07.035
   Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2548, DOI 10.1210/jc.2004-0395
   Leow MKS, 2003, J CLIN ENDOCR METAB, V88, P1961, DOI 10.1210/jc.2002-021704
   Meher AK, 2012, FREE RADICAL BIO MED, V52, P1708, DOI 10.1016/j.freeradbiomed.2012.02.022
   MOI P, 1994, P NATL ACAD SCI USA, V91, P9926, DOI 10.1073/pnas.91.21.9926
   Panchal SK, 2013, EUR J NUTR, V52, P559, DOI 10.1007/s00394-012-0358-9
   Panchal SK, 2012, J NUTR, V142, P1026, DOI 10.3945/jn.111.157263
   Pi JB, 2002, ENVIRON HEALTH PERSP, V110, P331, DOI 10.1289/ehp.02110331
   PROCTOR PH, 1984, PHYSIOL CHEM PHYS ME, V16, P175
   Rosen ED, 2006, NAT REV MOL CELL BIO, V7, P885, DOI 10.1038/nrm2066
   Salazar M, 2006, J BIOL CHEM, V281, P14841, DOI 10.1074/jbc.M513737200
   Sankhla M, 2012, CLIN LAB, V58, P385
   Satoh T, 2008, J NEUROCHEM, V104, P1116, DOI 10.1111/j.1471-4159.2007.05039.x
   Shimba S, 2001, J CELL SCI, V114, P2809
   Shin S, 2007, MOL CELL BIOL, V27, P7188, DOI 10.1128/MCB.00915-07
   Shin S, 2009, EUR J PHARMACOL, V620, P138, DOI 10.1016/j.ejphar.2009.08.022
   Skalicky J, 2009, BRATISL MED J, V110, P152
   Takahashi T, 2009, BIOCHEM BIOPH RES CO, V382, P549, DOI 10.1016/j.bbrc.2009.03.059
   Tan Y, 2011, DIABETES, V60, P625, DOI 10.2337/db10-1164
   Tuzcu M, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-28
   Weisberg SP, 2008, ENDOCRINOLOGY, V149, P3549, DOI 10.1210/en.2008-0262
   Wozniak SE, 2009, DIGEST DIS SCI, V54, P1847, DOI 10.1007/s10620-008-0585-3
   Xu JL, 2012, DIABETES, V61, P3208, DOI 10.2337/db11-1716
   Xue P, 2011, BIOCHEM BIOPH RES CO, V407, P360, DOI 10.1016/j.bbrc.2011.03.024
   Yokota T, 2013, DIABETES CARE, V36, P1341, DOI 10.2337/dc12-1161
   Yu Z, 2011, DIABETOLOGIA, V54, P922, DOI 10.1007/s00125-010-2001-8
   Zhang YKJ, 2012, TOXICOL APPL PHARM, V264, P305, DOI 10.1016/j.taap.2012.09.014
NR 47
TC 75
Z9 85
U1 1
U2 26
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2013
VL 2013
AR 184598
DI 10.1155/2013/184598
PG 7
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 222TS
UT WOS:000324755100001
PM 24194976
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Owens, J
AF Owens, Judith
CA Adolescent Sleep Working Grp
   Comm Adolescence
TI Insufficient Sleep in Adolescents and Young Adults: An Update on Causes
   and Consequences
SO PEDIATRICS
LA English
DT Article
DE adolescents; caffeine; car crashes; media use; obesity; sleep loss;
   sleepiness
ID SECONDARY-SCHOOL CHILDREN; BODY-MASS INDEX; INADEQUATE SLEEP;
   COLLEGE-STUDENTS; COMPUTER GAME; PRESCRIPTION STIMULANTS;
   CARDIOMETABOLIC RISK; CAFFEINE CONSUMPTION; JAPANESE ADOLESCENTS;
   DAYTIME SLEEPINESS
AB Chronic sleep loss and associated sleepiness and daytime impairments in adolescence are a serious threat to the academic success, health, and safety of our nation's youth and an important public health issue. Understanding the extent and potential short-and long-term repercussions of sleep restriction, as well as the unhealthy sleep practices and environmental factors that contribute to sleep loss in adolescents, is key in setting public policies to mitigate these effects and in counseling patients and families in the clinical setting. This report reviews the current literature on sleep patterns in adolescents, factors contributing to chronic sleep loss (ie, electronic media use, caffeine consumption), and health-related consequences, such as depression, increased obesity risk, and higher rates of drowsy driving accidents. The report also discusses the potential role of later school start times as a means of reducing adolescent sleepiness.
OI Adelman, William/0009-0007-6425-3196; Marcell, Arik/0000-0001-9873-478X
FU NIGMS NIH HHS [U54 GM104942] Funding Source: Medline
CR Åkerstedt T, 2001, J SLEEP RES, V10, P105, DOI 10.1046/j.1365-2869.2001.00248.x
   Al Mamun A, 2007, AM J EPIDEMIOL, V166, P1368, DOI 10.1093/aje/kwm224
   Al-Disi D, 2010, ENDOCR J, V57, P915, DOI 10.1507/endocrj.K10E-145
   American Academy of Pediatrics, 2014, PEDIATRICS, V134, P620
   An H, 2010, PSYCHIAT RES, V177, P318, DOI 10.1016/j.psychres.2010.03.007
   [Anonymous], J PSYCHOSOC NURS MEN
   [Anonymous], 2006, Sleep in America Polls
   Arora T, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0072406
   Beebe DW, 2007, J PEDIATR PSYCHOL, V32, P69, DOI 10.1093/jpepsy/jsj104
   Beebe DW, 2011, PEDIATR CLIN N AM, V58, P649, DOI 10.1016/j.pcl.2011.03.002
   Berkey CS, 2008, J PEDIATR, V153, P635, DOI 10.1016/j.jpeds.2008.04.072
   Bernstein GA, 2002, DRUG ALCOHOL DEPEN, V66, P1, DOI 10.1016/S0376-8716(01)00181-8
   Boivin DB, 1996, NATURE, V379, P540, DOI 10.1038/379540a0
   Brand S, 2009, J ADOLESCENCE, V32, P1189, DOI 10.1016/j.adolescence.2009.01.010
   Cain N, 2010, SLEEP MED, V11, P735, DOI 10.1016/j.sleep.2010.02.006
   Calamaro CJ, 2010, J SLEEP RES, V19, P559, DOI 10.1111/j.1365-2869.2010.00840.x
   Calamaro CJ, 2009, PEDIATRICS, V123, pE1005, DOI 10.1542/peds.2008-3641
   Cappuccio FP, 2008, SLEEP, V31, P619, DOI 10.1093/sleep/31.5.619
   CARSKADON MA, 1993, SLEEP, V16, P258, DOI 10.1093/sleep/16.3.258
   Carskadon MA, 1998, SLEEP, V21, P871, DOI 10.1093/sleep/21.8.871
   Carskadon MA, 2002, SLEEP, V25, P606, DOI 10.1093/sleep/25.6.606
   Catrett CD, 2009, J GENET PSYCHOL, V170, P287, DOI 10.1080/00221320903218331
   Chen MC, 2012, J SLEEP RES, V21, P68, DOI 10.1111/j.1365-2869.2011.00934.x
   Choi K, 2009, PSYCHIAT CLIN NEUROS, V63, P455, DOI 10.1111/j.1440-1819.2009.01925.x
   Clinkinbeard SS, 2011, J YOUTH ADOLESCENCE, V40, P916, DOI 10.1007/s10964-010-9594-6
   Collins L.M., 1997, The science of prevention: Methodological advances from alcohol and substance abuse research, P79, DOI DOI 10.1037/10222-003
   Connor J, 2002, BRIT MED J, V324, P1125, DOI 10.1136/bmj.324.7346.1125
   Connor J, 2001, ACCIDENT ANAL PREV, V33, P31, DOI 10.1016/S0001-4575(00)00013-0
   Coulombe JA, 2010, J PEDIATR PSYCHOL, V35, P790, DOI 10.1093/jpepsy/jsp097
   Countryman AJ, 2013, ANN BEHAV MED, V45, P121, DOI 10.1007/s12160-012-9428-8
   Crowley SJ, 2010, CHRONOBIOL INT, V27, P1469, DOI 10.3109/07420528.2010.503293
   Dahl RE, 1996, BIOL PSYCHIAT, V39, P400, DOI 10.1016/0006-3223(95)00190-5
   Daniel LC, 2012, ANN ALLERG ASTHMA IM, V109, P41, DOI 10.1016/j.anai.2012.05.015
   Danner F, 2008, J CLIN SLEEP MED, V4, P533
   Dexter Donn, 2003, WMJ, V102, P44
   Dodor BA, 2010, NUTR RES PRACT, V4, P528, DOI 10.4162/nrp.2010.4.6.528
   Dollman I, 2007, ACTA PAEDIATR, V96, P1011, DOI 10.1111/j.1651-2227.2007.00278.x
   Dworak M, 2007, PEDIATRICS, V120, P978, DOI 10.1542/peds.2007-0476
   Eaton DK, 2010, J ADOLESCENT HEALTH, V46, P399, DOI 10.1016/j.jadohealth.2009.10.011
   Eggermont S, 2006, J PAEDIATR CHILD H, V42, P428, DOI 10.1111/j.1440-1754.2006.00892.x
   Epstein R, 1998, SLEEP, V21, P250, DOI 10.1093/sleep/21.3.250
   Fitzgerald CT, 2011, J CLIN SLEEP MED, V7, P351, DOI 10.5664/JCSM.1188
   Garbarino S, 2001, SLEEP, V24, P203
   Garnier-Dykstra LM, 2012, J AM COLL HEALTH, V60, P226, DOI 10.1080/07448481.2011.589876
   Gau SSF, 2004, SLEEP, V27, P512
   Glozier N, 2010, SLEEP, V33, P1139, DOI 10.1093/sleep/33.9.1139
   Gromov I, 2009, CHILD ADOL PSYCH CL, V18, P929, DOI 10.1016/j.chc.2009.04.004
   Gupta NK, 2002, AM J HUM BIOL, V14, P762, DOI 10.1002/ajhb.10093
   Gupta R, 2008, INDIAN PEDIATR, V45, P183
   Harrison Y, 2000, J EXP PSYCHOL-APPL, V6, P236, DOI 10.1037//1076-898X.6.3.236
   Hasler G, 2004, SLEEP, V27, P661, DOI 10.1093/sleep/27.4.661
   Higuchi S, 2005, J SLEEP RES, V14, P267, DOI 10.1111/j.1365-2869.2005.00463.x
   Higuchi S, 2003, J APPL PHYSIOL, V94, P1773, DOI 10.1152/japplphysiol.00616.2002
   Huang YS, 2010, SLEEP MED, V11, P1035, DOI 10.1016/j.sleep.2010.04.009
   Hutchens L, 2008, ACCIDENT ANAL PREV, V40, P869, DOI 10.1016/j.aap.2007.10.001
   Ingram DG, 2013, SLEEP MED, V14, P172, DOI 10.1016/j.sleep.2012.11.011
   Jaehne A, 2009, SLEEP MED REV, V13, P363, DOI 10.1016/j.smrv.2008.12.003
   James JE, 2011, J ADOLESCENCE, V34, P665, DOI 10.1016/j.adolescence.2010.09.006
   Jenni OG, 2005, SLEEP, V28, P1446, DOI 10.1093/sleep/28.11.1446
   Johnson JG, 2004, ARCH PEDIAT ADOL MED, V158, P562, DOI 10.1001/archpedi.158.6.562
   Kang KT, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0078666
   Kheirandish-Gozal L, 2013, SLEEP MED, V14, P526, DOI 10.1016/j.sleep.2013.02.010
   Knutson KL, 2005, J PEDIATR-US, V147, P830, DOI 10.1016/j.jpeds.2005.07.019
   Knutson KL, 2007, PEDIATRICS, V119, pE1056, DOI 10.1542/peds.2006-2597
   Knutson KL, 2009, J PEDIATR-US, V154, P426, DOI 10.1016/j.jpeds.2008.08.035
   Kristjansson A. L., 2011, Journal of Caffeine Research, V1, P75
   Leproult R, 2010, ENDOCR DEV, V17, P11, DOI 10.1159/000262524
   Liou YM, 2010, J ADV NURS, V66, P1246, DOI 10.1111/j.1365-2648.2010.05293.x
   Liu XC, 2006, CURR OPIN PSYCHIATR, V19, P288, DOI 10.1097/01.yco.0000218600.40593.18
   Liu XC, 2004, SLEEP, V27, P1351, DOI 10.1093/sleep/27.7.1351
   Loessl B, 2008, CHILD CARE HLTH DEV, V34, P549, DOI 10.1111/j.1365-2214.2008.00845.x
   Lofthouse N, 2009, CHILD ADOL PSYCH CL, V18, P893, DOI 10.1016/j.chc.2009.04.007
   Lookatch SJ, 2012, J PSYCHOACTIVE DRUGS, V44, P86, DOI 10.1080/02791072.2012.662083
   Lopez J, 2010, J AM ACAD CHILD PSY, V49, P934, DOI 10.1016/j.jaac.2010.05.014
   Lowden A, 2009, ACCIDENT ANAL PREV, V41, P1001, DOI 10.1016/j.aap.2009.05.014
   Ludden AB, 2010, HEALTH EDUC BEHAV, V37, P330, DOI 10.1177/1090198109341783
   Lufi D, 2011, J CLIN SLEEP MED, V7, P137
   Lund HG, 2010, J ADOLESCENT HEALTH, V46, P124, DOI 10.1016/j.jadohealth.2009.06.016
   Majori S, 2009, J Prev Med Hyg, V50, P102
   Marco CA, 2012, BEHAV SLEEP MED, V10, P70, DOI 10.1080/15402002.2012.636298
   Marczinski CA, 2012, EXP CLIN PSYCHOPHARM, V20, P129, DOI 10.1037/a0026136
   Martin CA, 2008, THESCIENTIFICWORLDJO, V8, P513, DOI 10.1100/tsw.2008.82
   Martinez-Gomez D, 2011, SLEEP MED, V12, P997, DOI 10.1016/j.sleep.2011.05.009
   Matthews KA, 2012, SLEEP, V35, P1353, DOI 10.5665/sleep.2112
   McHale SM, 2011, J YOUTH ADOLESCENCE, V40, P666, DOI 10.1007/s10964-010-9574-x
   Mednick SC, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009775
   Miller Michael Craig, 2005, Harv Ment Health Lett, V22, P8
   Millman RP, 2005, PEDIATRICS, V115, P1774, DOI 10.1542/peds.2005-0772
   Moore M, 2011, SLEEP MED, V12, P239, DOI 10.1016/j.sleep.2010.07.020
   Munezawa T, 2011, SLEEP, V34, P1013, DOI 10.5665/SLEEP.1152
   Noland H, 2009, J SCHOOL HEALTH, V79, P224, DOI 10.1111/j.1746-1561.2009.00402.x
   O'Brien Erin M, 2005, Behav Sleep Med, V3, P113, DOI 10.1207/s15402010bsm0303_1
   O'Dea JA, 2003, HEALTH EDUC RES, V18, P98, DOI 10.1093/her/18.1.98
   Okun ML, 2011, J AFFECT DISORDERS, V130, P378, DOI 10.1016/j.jad.2010.07.015
   Olds T, 2010, SLEEP, V33, P1381, DOI 10.1093/sleep/33.10.1381
   Orbeta RL, 2006, J ADOLESCENT HEALTH, V38, P451, DOI 10.1016/j.jadohealth.2005.05.014
   Owens JA, 2010, ARCH PEDIAT ADOL MED, V164, P608, DOI 10.1001/archpediatrics.2010.96
   Pack AI, 1995, ACCIDENT ANAL PREV, V27, P769, DOI 10.1016/0001-4575(95)00034-8
   Pallesen S, 2011, J ADOLESCENCE, V34, P391, DOI 10.1016/j.adolescence.2010.02.005
   Patel NP, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-475
   Pérez A, 2010, PREV CHRONIC DIS, V7
   Philip P, 2006, SLEEP MED REV, V10, P347, DOI 10.1016/j.smrv.2006.04.002
   Pizza F, 2010, J CLIN SLEEP MED, V6, P41
   Pollak CP, 2003, PEDIATRICS, V111, P42, DOI 10.1542/peds.111.1.42
   Punamäki RL, 2007, J ADOLESCENCE, V30, P569, DOI 10.1016/j.adolescence.2006.07.004
   Randler C, 2009, J PSYCHOL, V143, P509, DOI 10.3200/JRL.143.5.509-520
   Regestein Q, 2010, PSYCHIAT RES, V176, P34, DOI 10.1016/j.psychres.2008.11.006
   Reissig CJ, 2009, DRUG ALCOHOL DEPEN, V99, P1, DOI 10.1016/j.drugalcdep.2008.08.001
   Roberts RE, 2009, J ADOLESCENCE, V32, P1045, DOI 10.1016/j.adolescence.2009.03.007
   Roehrs T, 2008, SLEEP MED REV, V12, P153, DOI 10.1016/j.smrv.2007.07.004
   Roenneberg T, 2004, CURR BIOL, V14, pR1038, DOI 10.1016/j.cub.2004.11.039
   Sagaspe P, 2007, SLEEP, V30, P1808, DOI 10.1093/sleep/30.12.1808
   Seicean A, 2007, SLEEP BREATH, V11, P285, DOI 10.1007/s11325-007-0108-z
   Shochat T, 2010, ACTA PAEDIATR, V99, P1396, DOI 10.1111/j.1651-2227.2010.01821.x
   Singleton RA, 2009, J STUD ALCOHOL DRUGS, V70, P355, DOI 10.15288/jsad.2009.70.355
   Sleep Health, HLTH PEOPL 2020 TOP
   Smith-Coggins R, 2006, ANN EMERG MED, V48, P596, DOI 10.1016/j.annemergmed.2006.02.005
   Snell EK, 2007, CHILD DEV, V78, P309, DOI 10.1111/j.1467-8624.2007.00999.x
   Spilsbury JC, 2004, ARCH PEDIAT ADOL MED, V158, P988, DOI 10.1001/archpedi.158.10.988
   STRAIN EC, 1995, J ROY SOC MED, V88, P437
   Sun YC, 2009, J EPIDEMIOL, V19, P303, DOI 10.2188/jea.JE20080095
   Taylor DJ, 2010, J ADOLESCENT HEALTH, V46, P610, DOI 10.1016/j.jadohealth.2009.12.010
   Taylor DJ, 2005, J SLEEP RES, V14, P239, DOI 10.1111/j.1365-2869.2005.00467.x
   TENNANT FS, 1976, PREV MED, V5, P70, DOI 10.1016/0091-7435(76)90010-4
   Urner M, 2009, CHRONOBIOL INT, V26, P1222, DOI 10.1080/07420520903244600
   Van Cauter E, 2008, SLEEP MED, V9, pS23, DOI 10.1016/S1389-9457(08)70013-3
   Van Cauter E, 2008, EUR J ENDOCRINOL, V159, pS59, DOI 10.1530/EJE-08-0298
   Van den Bulck J, 2004, SLEEP, V27, P101, DOI 10.1093/sleep/27.1.101
   Van den Bulck J, 2007, SLEEP, V30, P1220, DOI 10.1093/sleep/30.9.1220
   Van Hoorenbeeck K, 2013, OBESITY, V21, P1446, DOI 10.1002/oby.20337
   Vorona RD, 2011, J CLIN SLEEP MED, V7, P145
   Wahlstrom K., 2002, NASSP BULL, V86, P3, DOI DOI 10.1177/019263650208663302
   Weiss A, 2010, SLEEP, V33, P1201, DOI 10.1093/sleep/33.9.1201
   Whalen DJ, 2008, J PEDIATR PSYCHOL, V33, P358, DOI 10.1093/jpepsy/jsm086
   Wolfson A.R., 2005, NASSP BULL, V89, P47, DOI DOI 10.1177/019263650508964205
   Wolfson Amy R, 2007, Behav Sleep Med, V5, P194
   Yang CK, 2005, PEDIATRICS, V115, P250, DOI 10.1542/peds.2004-0815G
   Zeitzer JM, 2000, J PHYSIOL-LONDON, V526, P695, DOI 10.1111/j.1469-7793.2000.00695.x
NR 138
TC 991
Z9 1102
U1 36
U2 627
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
EI 1098-4275
J9 PEDIATRICS
JI Pediatrics
PD SEP
PY 2014
VL 134
IS 3
BP E921
EP E932
DI 10.1542/peds.2014-1696
PG 12
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA AO5DN
UT WOS:000341362600038
PM 25157012
OA Green Published
DA 2025-06-11
ER

PT J
AU Pascoe, MC
   Thompson, DR
   Ski, CF
AF Pascoe, Michaela C.
   Thompson, David R.
   Ski, Chantal F.
TI Yoga, mindfulness-based stress reduction and stress-related
   physiological measures: A meta-analysis
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE Yoga; Mindfulness-based stress reduction; Stress; Inflammation; Exercise
ID RANDOMIZED CONTROLLED-TRIAL; BREAST-CANCER SURVIVORS; LIFE-STYLE
   MODIFICATION; HEART-RATE-VARIABILITY; BLOOD-PRESSURE; MAJOR DEPRESSION;
   HATHA-YOGA; METABOLIC SYNDROME; RESTORATIVE YOGA; DIURNAL CORTISOL
AB Background and objectives: Practices that include yoga asanas and mindfulness-based stress reduction for the management of stress are increasingly popular; however, the neurobiological effects of these practices on stress reactivity are not well understood. Many studies investigating the effects of such practices fail to include an active control group. Given the frequency with which people are selecting such interventions as a form of self management, it is important to determine their effectiveness. Thus, this review investigates the effects of practices that include yoga asanas, with and without mindfulness-based stress reduction, compared to an active control, on physiological markers of stress.
   Materials and methods: A systematic review and meta-analysis of randomised controlled trials published in English compared practices that included yoga asanas, with and without mindfulness-based stress reduction, to an active control, on stress-related physiological measures. The review focused on studies that measured physiological parameters such as blood pressure, heart rate, cortisol and peripheral cytokine expression. MEDLINE, AMED, CINAHL, PsycINFO, SocINDEX, PubMed, and Scopus were searched in May 2016 and updated in December 2016. Randomised controlled trials were included if they assessed at least one of the following outcomes: heart rate, blood pressure, heart rate variability, mean arterial pressure, C-reactive, protein, interleukins or cortisol. Risk of bias assessments included sequence generation, allocation-concealment, blinding of assessors, incomplete outcome data, selective outcome reporting and other sources of bias. Meta-analysis was undertaken using Comprehensive Meta-Analysis Software Version 3. Sensitivity analyses were performed using 'one-study removed' analysis. Subgroup analysis was conducted for different yoga and control group types, including mindfulness-based stress reduction versus non-mindfulness-based stress reduction based interventions, different populations, length of intervention, and method of data analysis. A random-effects model was used in all analyses.
   Results: Forty two studies were included in the meta-analysis. Interventions that included yoga asanas were associated with reduced evening cortisol, waking cortisol, ambulatory systolic blood pressure, resting heart rate, high frequency heart rate variability, fasting blood glucose, cholesterol and low density lipoprotein, compared to active control. However, the reported interventions were heterogeneous.
   Conclusions: Practices that include yoga asanas appear to be associated with improved regulation of the sympathetic nervous system and hypothalamic-pituitary-adrenal system in various populations.
C1 [Pascoe, Michaela C.] Peter MacCallum Canc Ctr, Dept Canc Experiences, 305 Grattan St, Melbourne, Vic 3000, Australia.
   [Thompson, David R.; Ski, Chantal F.] Univ Melbourne, Dept Psychiat, Melbourne, Vic 3010, Australia.
   [Thompson, David R.] Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic 3000, Australia.
C3 Peter Maccallum Cancer Center; University of Melbourne; Monash
   University
RP Pascoe, MC (corresponding author), Peter MacCallum Canc Ctr, Dept Canc Experiences, 305 Grattan St, Melbourne, Vic 3000, Australia.
EM Michaela.Pascoe@petermac.org; David.Thompson@unimelb.edu.au;
   Chantal.Ski@unimelb.edu.au
RI Ski, Chantal/HNS-2574-2023; Thompson, David/E-2431-2018
OI Pascoe, Michaela/0000-0002-3831-5660; Ski, Chantal/0000-0003-1324-2933;
   Thompson, David/0000-0001-8518-6307
CR Agelink MW, 2002, PSYCHIAT RES, V113, P139, DOI 10.1016/S0165-1781(02)00225-1
   Alesci S, 2005, J CLIN ENDOCR METAB, V90, P2522, DOI 10.1210/jc.2004-1667
   Teofilo MMA, 2014, J PSYCHIATR RES, V58, P181, DOI 10.1016/j.jpsychires.2014.07.030
   [Anonymous], 2016, EVOLUTIONARY ORIGINS
   [Anonymous], CLIN J PAIN
   Babbar S, 2016, AM J OBSTET GYNECOL, V214, DOI 10.1016/j.ajog.2015.12.032
   Bagga O P, 1983, Indian Heart J, V35, P39
   Billman GE, 2013, FRONT PHYSIOL, V4, DOI 10.3389/fphys.2013.00026
   Billman GE, 2011, FRONT PHYSIOL, V2, DOI 10.3389/fphys.2011.00086
   BLUMENTHAL JA, 1991, AM J CARDIOL, V67, P633, DOI 10.1016/0002-9149(91)90904-Y
   Borenstein M, 2021, Introduction to Meta-Analysis
   Bower JE, 2016, BRAIN BEHAV IMMUN, V51, P1, DOI 10.1016/j.bbi.2015.06.012
   Bower JE, 2014, PSYCHONEUROENDOCRINO, V43, P20, DOI 10.1016/j.psyneuen.2014.01.019
   Bowman AJ, 1997, EUR J CLIN INVEST, V27, P443, DOI 10.1046/j.1365-2362.1997.1340681.x
   Brown ES, 2004, BIOL PSYCHIAT, V55, P1, DOI 10.1016/S0006-3223(03)00473-6
   Camm AJ, 1996, EUR HEART J, V17, P354
   Carlson LE, 2015, CANCER-AM CANCER SOC, V121, P476, DOI 10.1002/cncr.29063
   Carlson LE, 2013, J CLIN ONCOL, V31, P3119, DOI 10.1200/JCO.2012.47.5210
   Chacko SA, 2016, COMPLEMENT THER MED, V28, P13, DOI 10.1016/j.ctim.2016.07.001
   Clarke Tainya C, 2015, Natl Health Stat Report, P1
   Cohen DL, 2016, J CLIN HYPERTENS, V18, P809, DOI 10.1111/jch.12772
   Cohen DL, 2011, EVID-BASED COMPL ALT, V2011, P1, DOI 10.1093/ecam/nep130
   Corey SM, 2014, PSYCHONEUROENDOCRINO, V49, P260, DOI 10.1016/j.psyneuen.2014.07.012
   Cornelissen VA, 2005, HYPERTENSION, V46, P667, DOI 10.1161/01.HYP.0000184225.05629.51
   Cramer H, 2013, DEPRESS ANXIETY, V30, P1068, DOI 10.1002/da.22166
   Creswell JD, 2016, BIOL PSYCHIAT, V80, P53, DOI 10.1016/j.biopsych.2016.01.008
   Creswell JD, 2012, BRAIN BEHAV IMMUN, V26, P1095, DOI 10.1016/j.bbi.2012.07.006
   CUSUMANO JA, 1993, APPL PSYCHOL-INT REV, V42, P77, DOI 10.1111/j.1464-0597.1993.tb00725.x
   Ding Ding, 2014, BMC Res Notes, V7, P172, DOI 10.1186/1756-0500-7-172
   Dortland AKBV, 2010, J CLIN PSYCHIAT, V71, P729, DOI 10.4088/JCP.08m04865blu
   Ebnezar John, 2012, Int J Yoga, V5, P28, DOI 10.4103/0973-6131.91708
   Farmer Jared., 2012, Reviews in American History, V40, P145
   Feldman C, 2016, CHEST, V149, P603, DOI 10.1016/j.chest.2015.11.002
   Field T, 2013, J BODYW MOV THER, V17, P397, DOI 10.1016/j.jbmt.2013.03.010
   Franco A, 2014, SCIENCE, V345, P1502, DOI 10.1126/science.1255484
   Gard T, 2014, FRONT HUM NEUROSCI, V8, DOI 10.3389/fnhum.2014.00770
   Gold PW, 2015, MOL PSYCHIATR, V20, P32, DOI 10.1038/mp.2014.163
   Goldberg SB, 2014, J ALTERN COMPLEM MED, V20, P630, DOI 10.1089/acm.2014.0080
   Goldstein DS, 2011, EXP PHYSIOL, V96, P1255, DOI 10.1113/expphysiol.2010.056259
   Goodyer IM, 2000, BRIT J PSYCHIAT, V177, P499, DOI 10.1192/bjp.177.6.499
   Gothe NP, 2016, BIOL PSYCHOL, V121, P109, DOI 10.1016/j.biopsycho.2016.10.010
   Granath Jens, 2006, Cognitive Behaviour Therapy, V35, P3, DOI 10.1080/16506070500401292
   Hagins M, 2014, J CLIN HYPERTENS, V16, P54, DOI 10.1111/jch.12244
   Hagins M, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/607134
   Hannestad J, 2011, NEUROPSYCHOPHARMACOL, V36, P2452, DOI 10.1038/npp.2011.132
   Harinath K, 2004, J ALTERN COMPLEM MED, V10, P261, DOI 10.1089/107555304323062257
   Hayney MS, 2014, HUM VACC IMMUNOTHER, V10, P83, DOI 10.4161/hv.26661
   Henriksen EJ, 2011, FREE RADICAL BIO MED, V51, P993, DOI 10.1016/j.freeradbiomed.2010.12.005
   Higgins J, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.ED000049
   Hughes JW, 2013, PSYCHOSOM MED, V75, P721, DOI 10.1097/PSY.0b013e3182a3e4e5
   Innes KE, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/294058
   Iwata M, 2013, BRAIN BEHAV IMMUN, V31, P105, DOI 10.1016/j.bbi.2012.12.008
   Jedel S, 2014, DIGESTION, V89, P142, DOI 10.1159/000356316
   Jones SMW, 2016, COMPLEMENT THER MED, V26, P66, DOI 10.1016/j.ctim.2016.03.001
   Jung HY, 2015, NURS HEALTH SCI, V17, P516, DOI 10.1111/nhs.12229
   Kahn Steven E., 2000, American Journal of Medicine, V108, p2S, DOI 10.1016/S0002-9343(00)00336-3
   Kalupahana NS, 2012, MOL ASPECTS MED, V33, P26, DOI 10.1016/j.mam.2011.10.011
   Kanaya AM, 2014, J DIABETES COMPLICAT, V28, P406, DOI 10.1016/j.jdiacomp.2013.12.001
   Kiecolt-Glaser JK, 2014, J CLIN ONCOL, V32, P1040, DOI 10.1200/JCO.2013.51.8860
   Kiecolt-Glaser JK, 2010, PSYCHOSOM MED, V72, P113, DOI 10.1097/PSY.0b013e3181cb9377
   Lanfranchi PA, 2002, AM J PHYSIOL-REG I, V283, pR815, DOI 10.1152/ajpregu.00051.2002
   LeMoult J, 2015, J ABNORM PSYCHOL, V124, P850, DOI 10.1037/abn0000087
   Li AW, 2012, ALTERN MED REV, V17, P21
   Macleod MR, 2015, PLOS BIOL, V13, DOI 10.1371/journal.pbio.1002273
   Maes M, 2008, NEUROENDOCRINOL LETT, V29, P287
   Malarkey WB, 2013, BRAIN BEHAV IMMUN, V27, P145, DOI 10.1016/j.bbi.2012.10.009
   Michalsen A, 2005, MED SCI MONITOR, V11, pCR555
   MILLER JJ, 1995, GEN HOSP PSYCHIAT, V17, P192, DOI 10.1016/0163-8343(95)00025-M
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Nerurkar A, 2011, ARCH INTERN MED, V171, P862, DOI 10.1001/archinternmed.2011.160
   Nidhi R, 2012, INT J GYNECOL OBSTET, V118, P37, DOI 10.1016/j.ijgo.2012.01.027
   Olefsky JM, 2010, ANNU REV PHYSIOL, V72, P219, DOI 10.1146/annurev-physiol-021909-135846
   Ospina Maria B, 2007, Evid Rep Technol Assess (Full Rep), P1
   Palta P, 2012, J URBAN HEALTH, V89, P308, DOI 10.1007/s11524-011-9654-6
   Pariante CM, 2003, J NEUROENDOCRINOL, V15, P811
   Parma DL, 2015, SPRINGERPLUS, V4, DOI 10.1186/s40064-015-0912-z
   Pascoe MC, 2015, J PSYCHIATR RES, V68, P270, DOI 10.1016/j.jpsychires.2015.07.013
   Patil SG, 2015, COMPLEMENT THER MED, V23, P562, DOI 10.1016/j.ctim.2015.06.002
   Penman Stephen, 2012, Int J Yoga, V5, P92, DOI 10.4103/0973-6131.98217
   Pflueger LW, 2011, RELIG STUD REV, V37, P235, DOI 10.1111/j.1748-0922.2011.01543_4.x
   Praissman S, 2008, J AM ACAD NURSE PRAC, V20, P212, DOI 10.1111/j.1745-7599.2008.00306.x
   Pruessner M, 2003, PSYCHOSOM MED, V65, P92, DOI 10.1097/01.PSY.0000040950.22044.10
   Pullen PR, 2008, J CARD FAIL, V14, P407, DOI 10.1016/j.cardfail.2007.12.007
   Pullen PR, 2010, MED SCI SPORT EXER, V42, P651, DOI 10.1249/MSS.0b013e3181bf24c4
   Raghavendra RM, 2009, INTEGR CANCER THER, V8, P37, DOI 10.1177/1534735409331456
   Rao Raghavendra M, 2008, Int J Yoga, V1, P11, DOI [10.4103/0973-6131.36795, 10.4103/0973-6131.36789]
   Ray US, 2001, INDIAN J MED RES, V114, P215
   Riley K.E., 2015, HEALTH PSYCHOL REV, V9, P379, DOI DOI 10.1080/17437199.2014.981778
   Ruby M, 2016, J PHYS ACT HEALTH, V13, P754, DOI 10.1123/jpah.2015-0493
   Saptharishi Lg, 2009, Indian J Community Med, V34, P329, DOI 10.4103/0970-0218.58393
   Sawane Manish Vinayak, 2015, Int J Yoga, V8, P96, DOI 10.4103/0973-6131.154069
   Sieverdes JC, 2014, J ALTERN COMPLEM MED, V20, P241, DOI 10.1089/acm.2013.0139
   Tall AR, 2015, NAT REV IMMUNOL, V15, P104, DOI 10.1038/nri3793
   Telles S., 1998, INT J REHABIL HLTH, V4, P17
   Thayer JF, 2011, HANDBOOK OF BEHAVIORAL MEDICINE: METHODS AND APPLICATIONS, P723, DOI 10.1007/978-0-387-09488-5_47
   Thiyagarajan R, 2015, HYPERTENS RES, V38, P48, DOI 10.1038/hr.2014.126
   Travis F, 2000, INT J NEUROSCI, V100, P77, DOI 10.3109/00207450008999678
   Ventriglio A, 2015, CURR PHARM DESIGN, V21, P1379, DOI 10.2174/1381612821666150105121244
   Wardle Jon, 2014, Int J Yoga, V7, P9, DOI 10.4103/0973-6131.123471
   Wesseling K.H., 1985, PSYCHOPHYSIOLOGY CAR, P69
   Wysokinski A, 2015, DIABETES METAB SYND, V9, P168, DOI 10.1016/j.dsx.2015.04.004
   Yang K, 2011, EVID-BASED COMPL ALT, V2011, P1, DOI 10.1093/ecam/nep117
   Ziv A, 2013, J HUM HYPERTENS, V27, P594, DOI 10.1038/jhh.2013.29
NR 103
TC 259
Z9 291
U1 10
U2 180
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD DEC
PY 2017
VL 86
BP 152
EP 168
DI 10.1016/j.psyneuen.2017.08.008
PG 17
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA FN1WG
UT WOS:000415781300019
PM 28963884
DA 2025-06-11
ER

PT J
AU Zaman, CF
   Sultana, J
   Dey, P
   Dutta, J
   Mustarin, S
   Tamanna, N
   Roy, A
   Bhowmick, N
   Khanam, M
   Sultana, S
   Chowdhury, S
   Khanam, F
   Sakibuzzaman, M
   Dutta, P
AF Zaman, Chowdhury F.
   Sultana, Jakia
   Dey, Proma
   Dutta, Jui
   Mustarin, Sadia
   Tamanna, Nuzhat
   Roy, Aditi
   Bhowmick, Nisha
   Khanam, Mousumi
   Sultana, Sadia
   Chowdhury, Selia
   Khanam, Farjana
   Sakibuzzaman, Md
   Dutta, Priyata
TI A Multidisciplinary Approach and Current Perspective of Nonalcoholic
   Fatty Liver Disease: A Systematic Review
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE nafld; nonalcoholic fatty liver disease; covid-19; gut microbiota;
   hepatocellular carcinoma (hcc); metabolic syndrome; obesity;
   nonalcoholic fatty liver disease (nafld)
ID HEPATOCELLULAR-CARCINOMA; MEDITERRANEAN DIET; PATHOGENESIS; PREVENTION;
   MANAGEMENT; FUTURE
AB In recent times, nonalcoholic fatty liver disease (NAFLD) has been considered one of the major causes of liver disease across the world. NAFLD is defined as the deposition of triglycerides in the liver and is associated with obesity and metabolic syndrome. Hyperinsulinemia, insulin resistance (IR), fatty liver, hepatocyte injury, unbalanced proinflammatory cytokines, mitochondrial dysfunction, oxidative stress, liver inflammation, and fibrosis are the main pathogenesis in NAFLD. Recent studies suggest that the action of intestinal microbiota through chronic inflammation, increased intestinal permeability, and energy uptake plays a vital role in NAFLD. Moreover, polycystic ovarian syndrome also causes NAFLD development through IR. Age, gender, race, ethnicity, sleep, diet, sedentary lifestyle, and genetic and epigenetic pathways are some contributing factors of NAFLD that can exacerbate the risk of liver cirrhosis and hepatocellular carcinoma (HCC) and eventually lead to death. NAFLD has various presentations, including fatigue, unexplained weight loss, bloating, upper abdominal pain, decreased appetite, headache, anxiety, poor sleep, increased thirst, palpitation, and a feeling of warmth. Some studies have shown that NAFLD with severe coronavirus disease 2019 (COVID-19) has poor outcomes. The gold standard for NAFLD diagnosis is liver biopsy. Other diagnostic tools are imaging tests, serum biomarkers, microbiota markers, and tests for extrahepatic complications. There are no specific treatments for NAFLD. Therefore, the main concern for NAFLD is treating the comorbid conditions such as anti-diabetic agents for type 2 diabetes mellitus, statins to reduce HCC progression, antioxidants to prevent hepatocellular damage, and bariatric surgery for patients with a BMI of >40 kg/m(2) and >35 kg/m(2) with comorbidities. Lifestyle and dietary changes are considered preventive strategies against NAFLD advancement. Inadequate treatment of NAFLD further leads to cardiac consequences, sleep apnea, chronic kidney disease, and inflammatory bowel disease. In this systematic review, we have briefly discussed the risk factors, pathogenesis, clinical features, and numerous consequences of NAFLD. We have also reviewed various guidelines for NAFLD diagnosis along with existing therapeutic strategies for the management and prevention of the disease.
C1 [Zaman, Chowdhury F.] Jahurul Islam Med Coll & Hosp, Med & Surg, Kishoreganj, Bangladesh.
   [Sultana, Jakia; Dutta, Jui] Cumilla Med Coll, Med, Cumilla, Bangladesh.
   [Dey, Proma] Chittagong Med Coll, Internal Med, Chattogram, Bangladesh.
   [Mustarin, Sadia] Mymensingh Med Coll, Med, Mymensingh, Bangladesh.
   [Tamanna, Nuzhat] Rangpur Med Coll & Hosp, Med, Rangpur, Bangladesh.
   [Roy, Aditi] Sher E Bangla Med Coll, Med, Barisal, Bangladesh.
   [Bhowmick, Nisha] Shaheed Ziaur Rahman Med Coll, Med, Bogra, Bangladesh.
   [Khanam, Mousumi; Chowdhury, Selia] Dhaka Med Coll, Internal Med, Dhaka, Bangladesh.
   [Sultana, Sadia] Anwer Khan Modern Med Coll, Med, Dhaka, Bangladesh.
   [Khanam, Farjana] Cent Med Coll, Med, Cumilla, Bangladesh.
   [Sakibuzzaman, Md] Univ Toledo, Neurol, 2801 W Bancroft St, Toledo, OH 43606 USA.
   [Sakibuzzaman, Md] Univ Mississippi, Med Ctr, Internal Med, Jackson, MS 39216 USA.
   [Sakibuzzaman, Md] Sir Salimullah Med Coll, Internal Med, Dhaka, Bangladesh.
   [Sakibuzzaman, Md] Mayo Clin, Expt Pathol Canc Biol, Rochester, MN USA.
   [Dutta, Priyata] St Joseph Mercy Ann Arbor, Internal Med, Trinity Hlth, Ann Arbor, MI USA.
C3 Chittagong Medical College; Mymensingh Medical College; Rangpur Medical
   College; Sher-E-Bangla Medical College (SBMC); Dhaka Medical College;
   University System of Ohio; University of Toledo; University of
   Mississippi Medical Center; University of Mississippi; Sir Salimullah
   Medical College; Mayo Clinic; Saint Joseph Mercy Health System (SJMHS)
RP Dey, P (corresponding author), Chittagong Med Coll, Internal Med, Chattogram, Bangladesh.
EM proma.dey.cmc@gmail.com
RI Dutta, Priyata/KSM-6252-2024
OI Dutta, Priyata/0000-0001-7954-9511
CR Al-Dayyat HM, 2018, DIABETES METAB SYND, V12, P569, DOI 10.1016/j.dsx.2018.03.016
   Argyrou C, 2017, J BUON, V22, P6
   Bedossa P, 2017, LIVER INT, V37, P85, DOI 10.1111/liv.13301
   Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI 10.1002/hep.29367
   Cotter TG, 2020, GASTROENTEROLOGY, V158, P1851, DOI 10.1053/j.gastro.2020.01.052
   Doumas M, 2018, CURR PHARM DESIGN, V24, P4587, DOI 10.2174/1381612825666190117114305
   Elhence A, 2020, INDIAN J GASTROENTER, V39, P22, DOI 10.1007/s12664-020-01021-2
   Gelli C, 2017, WORLD J GASTROENTERO, V23, P3150, DOI 10.3748/wjg.v23.i17.3150
   Issa D, 2018, LIVER INT, V38, P56, DOI 10.1111/liv.13676
   Karaivazoglou K, 2020, EUR J GASTROEN HEPAT, V32, P903, DOI 10.1097/MEG.0000000000001679
   Khoonsari Mahmoodreza, 2017, Iran J Pathol, V12, P99
   Kumarendran B, 2018, PLOS MED, V15, DOI 10.1371/journal.pmed.1002542
   Lang S, 2020, CELL HOST MICROBE, V28, P233, DOI 10.1016/j.chom.2020.07.007
   Leoni S, 2018, WORLD J GASTROENTERO, V24, P3361, DOI 10.3748/wjg.v24.i30.3361
   Liu K, 2018, ADV EXP MED BIOL, V1061, P3, DOI 10.1007/978-981-10-8684-7_2
   Lonardo A, 2019, HEPATOLOGY, V70, P1457, DOI 10.1002/hep.30626
   Macut D, 2018, CURR PHARM DESIGN, V24, P4593, DOI 10.2174/1381612825666190117100751
   Major Piotr, 2017, Pol Przegl Chir, V89, P1, DOI 10.5604/01.3001.0009.6003
   Mansour A, 2019, J DIGEST DIS, V20, P271, DOI 10.1111/1751-2980.12751
   Mazhar K, 2019, MED CLIN N AM, V103, P57, DOI 10.1016/j.mcna.2018.08.005
   Moore JB, 2019, P NUTR SOC, V78, P290, DOI 10.1017/S0029665119000570
   Mundi MS, 2020, NUTR CLIN PRACT, V35, P72, DOI 10.1002/ncp.10449
   Muthiah MD, 2022, DIABETES OBES METAB, V24, P3, DOI 10.1111/dom.14521
   Neuschwander-Tetri BA, 2017, BMC MED, V15, DOI 10.1186/s12916-017-0806-8
   Page MJ, 2021, PLOS MED, V18, DOI 10.1371/journal.pmed.1003583
   Papatheodoridi M, 2018, CURR PHARM DESIGN, V24, P4574, DOI 10.2174/1381612825666190117102111
   Patel SS, 2019, DRUGS, V79, P75, DOI 10.1007/s40265-018-1040-1
   Portincasa P, 2020, EUR J CLIN INVEST, V50, DOI 10.1111/eci.13338
   Reeves HL, 2016, DIGEST DIS SCI, V61, P1234, DOI 10.1007/s10620-016-4085-6
   Rojas-Feria M, 2013, WORLD J GASTROENTERO, V19, P7327, DOI 10.3748/wjg.v19.i42.7327
   Ruissen MM, 2020, EUR J ENDOCRINOL, V183, pR57, DOI 10.1530/EJE-20-0065
   Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012
   Schwenger KJP, 2019, EUR J NUTR, V58, P1771, DOI 10.1007/s00394-018-1844-5
   Singh A, 2021, DIAB MET SYND CLIN R, V15, P813, DOI 10.1016/j.dsx.2021.03.019
   Tanaka N, 2019, WORLD J GASTROENTERO, V25, P163, DOI 10.3748/wjg.v25.i2.163
   Targher G, 2021, LANCET GASTROENTEROL, V6, pS78, DOI 10.1016/S2468-1253(21)00020-0
   Targher G, 2021, DIABETES METAB, V47, DOI 10.1016/j.diabet.2020.101215
   Ullah R, 2019, INT J BIOL SCI, V15, P265, DOI 10.7150/ijbs.30121
   Valenti LVC, 2018, CURR PHARM DESIGN, V24, P4566, DOI 10.2174/1381612825666190119113836
   Vranic L, 2021, MEDICINA-LITHUANIA, V57, DOI 10.3390/medicina57101057
   Wijarnpreecha K, 2021, CLIN MOL HEPATOL, V27, P221, DOI 10.3350/cmh.2020.0239
   Xu YL, 2021, LIPIDS HEALTH DIS, V20, DOI 10.1186/s12944-021-01564-z
   Younossi ZM, 2019, J HEPATOL, V70, P531, DOI 10.1016/j.jhep.2018.10.033
   Zhang X, 2018, ADV EXP MED BIOL, V1061, P55, DOI 10.1007/978-981-10-8684-7_5
   Zhou JH, 2019, WORLD J GASTROENTERO, V25, P1307, DOI 10.3748/wjg.v25.i11.1307
NR 45
TC 10
Z9 10
U1 1
U2 27
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD SEP 27
PY 2022
VL 14
IS 9
AR e29657
DI 10.7759/cureus.29657
PG 12
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA 5M5CF
UT WOS:000871112300003
PM 36320966
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cernackova, A
   Durackova, Z
   Trebaticka, J
   Mravec, B
AF Cernackova, Alena
   Durackova, Zdenka
   Trebaticka, Jana
   Mravec, Boris
TI Neuroinflammation and depressive disorder: The role of the hypothalamus
SO JOURNAL OF CLINICAL NEUROSCIENCE
LA English
DT Review
DE Inflammation; Hypothalamus; HPA axis; Stress; Depressive disorder
ID SOCIAL DEFEAT PROMOTES; CHRONIC STRESS; MESSENGER-RNA; IMMUNE-SYSTEM;
   HPA AXIS; KAPPA-B; INFLAMMATION; INTERLEUKIN-1-BETA; ACTIVATION;
   MICROGLIA
AB Data accumulated over the last two decades has demonstrated that hypothalamic inflammation plays an important role in the etiopathogenesis of the most prevalent diseases, such as cardiovascular diseases, metabolic syndrome, and even cancer. Recent findings indicate that hypothalamic inflammation is also associated with stress exposure and certain psychiatric diseases, such as depressive disorder. Mechanistic studies have shown that intense and/or chronic stress exposure is accompanied by the synthesis of inflammatory molecules in the hypothalamus, altered hypothalamic-pituitary-adrenal axis activity, and development of glucocorticoid resistance. Consequently, these factors might play a role in the etiopathogenesis of psychiatric disorders. We propose that hypothalamic inflammation represents an interconnection between somatic diseases and depressive disorder. These assumptions are discussed in this mini-review in the light of available data from studies focusing on hypothalamic inflammation. (C) 2020 Elsevier Ltd. All rights reserved.
C1 [Cernackova, Alena; Mravec, Boris] Comenius Univ, Fac Med, Inst Physiol, Bratislava, Slovakia.
   [Cernackova, Alena; Mravec, Boris] Slovak Acad Sci, Inst Expt Endocrinol, Biomed Res Ctr, Bratislava, Slovakia.
   [Durackova, Zdenka] Comenius Univ, Fac Med, Inst Med Chem Biochem & Clin Biochem, Bratislava, Slovakia.
   [Trebaticka, Jana] Comenius Univ, Fac Med, Dept Child & Adolescent Psychiat, Bratislava, Slovakia.
   [Trebaticka, Jana] Child Univ Hosp, Bratislava, Slovakia.
C3 Comenius University Bratislava; Slovak Academy of Sciences; Slovak
   Academy of Sciences; Biomedical Research Center, SAS; Institute of
   Experimental Endocrinology, SAS; Comenius University Bratislava;
   Comenius University Bratislava
RP Cernackova, A (corresponding author), Fac Med, Inst Physiol, Sasinkova 2, Bratislava 81372, Slovakia.
EM cernackova1@uniba.sk
RI Ďuračková, Zdenka/ABD-1310-2021; Cernackova, Alena/HLX-2024-2023
OI Mravec, Boris/0000-0002-3177-6819
FU Slovak Research and Development Agency [APVV-17-0090, APVV 15-0063];
   Interreg, Slovakia-Austria; European Regional Development Fund [V-A
   SK-AT V014 -NutriAging]
FX This work was supported by the Slovak Research and Development Agency
   (APVV-17-0090, APVV 15-0063) Interreg, Slovakia-Austria, European
   Regional Development Fund: V-A SK-AT V014 -NutriAging.
CR Audet MC, 2011, BRAIN BEHAV IMMUN, V25, P1197, DOI 10.1016/j.bbi.2011.03.010
   Black DS, 2016, ANN NY ACAD SCI, V1373, P13, DOI 10.1111/nyas.12998
   Blandino P, 2009, BRAIN BEHAV IMMUN, V23, P958, DOI 10.1016/j.bbi.2009.04.013
   Bremner P, 2002, J PHARM PHARMACOL, V54, P453, DOI 10.1211/0022357021778637
   Burfeind KG, 2016, SEMIN CELL DEV BIOL, V54, P42, DOI 10.1016/j.semcdb.2015.10.038
   Busillo JM, 2011, J BIOL CHEM, V286, P38703, DOI 10.1074/jbc.M111.275370
   Calcia MA, 2016, PSYCHOPHARMACOLOGY, V233, P1637, DOI 10.1007/s00213-016-4218-9
   Capuron L, 2002, MOL PSYCHIATR, V7, P468, DOI 10.1038/sj.mp.4000995
   Cohen S, 2012, P NATL ACAD SCI USA, V109, P5995, DOI 10.1073/pnas.1118355109
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   de Git KCG, 2015, OBES REV, V16, P207, DOI 10.1111/obr.12243
   Diniz BS, 2010, AM J GERIAT PSYCHIAT, V18, P172, DOI 10.1097/JGP.0b013e3181c2947f
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Duque ED, 2016, FRONT ENDOCRINOL, V7, DOI 10.3389/fendo.2016.00078
   Durackova Z, 2018, TARGETING MITOCHONDR, P293
   Escoll P, 2015, MEDIAT INFLAMM, V2015, DOI 10.1155/2015/347965
   Eton O, 2002, CANCER, V95, P127, DOI 10.1002/cncr.10631
   Frank MG, 2014, PSYCHONEUROENDOCRINO, V40, P191, DOI 10.1016/j.psyneuen.2013.11.006
   Galecki P, 2018, PROG NEURO-PSYCHOPH, V80, P291, DOI 10.1016/j.pnpbp.2017.03.016
   Goldstein DS, 2017, AUTON NEUROSCI-BASIC, V208, P15, DOI 10.1016/j.autneu.2017.09.001
   Goshen I, 2008, MOL PSYCHIATR, V13, P717, DOI 10.1038/sj.mp.4002055
   Goshen I, 2009, FRONT NEUROENDOCRIN, V30, P30, DOI 10.1016/j.yfrne.2008.10.001
   Heim C, 2008, PSYCHONEUROENDOCRINO, V33, P693, DOI 10.1016/j.psyneuen.2008.03.008
   Hestad KA, 2017, FRONT PSYCHOL, V8, DOI 10.3389/fpsyg.2017.01561
   Husted KS, 2016, MEDICINA-LITHUANIA, V52, P139, DOI 10.1016/j.medici.2016.05.003
   Kennedy Sidney H, 2008, Dialogues Clin Neurosci, V10, P271
   Kiecolt-Glaser JK, 2010, PSYCHOSOM MED, V72, P113, DOI 10.1097/PSY.0b013e3181cb9377
   Kopp BL, 2013, PHYSIOL BEHAV, V122, P246, DOI 10.1016/j.physbeh.2013.05.030
   Lehnardt S, 2002, MOL BIOL CELL, V13, p537A
   Levine J, 1999, NEUROPSYCHOBIOLOGY, V40, P171, DOI 10.1159/000026615
   LINTHORST ACE, 1994, ENDOCRINOLOGY, V135, P520, DOI 10.1210/en.135.2.520
   Lira FS, 2011, NUTR METAB, V8
   Liu YZ, 2017, FRONT HUM NEUROSCI, V11, DOI 10.3389/fnhum.2017.00316
   Lotrich FE, 2007, J PSYCHOSOM RES, V63, P131, DOI 10.1016/j.jpsychores.2007.05.013
   Martinac M, 2017, PSYCHIAT DANUB, V29, P39, DOI 10.24869/psyd.2017.39
   McEwen BS, 2007, PHYSIOL REV, V87, P873, DOI 10.1152/physrev.00041.2006
   Merkulov VM, 2017, BIOCHEMISTRY-MOSCOW+, V82, P351, DOI 10.1134/S0006297917030142
   MINAMI M, 1991, NEUROSCI LETT, V123, P254, DOI 10.1016/0304-3940(91)90944-O
   Mooventhan A, 2017, J CLIN NEUROSCI, V43, P61, DOI 10.1016/j.jocn.2017.05.012
   Mravec B, 2019, CELL MOL NEUROBIOL, V39, P11, DOI 10.1007/s10571-018-0631-4
   Murray CJL, 1997, LANCET, V349, P1436, DOI 10.1016/S0140-6736(96)07495-8
   Myint AM, 2007, J AFFECT DISORDERS, V98, P143, DOI 10.1016/j.jad.2006.07.013
   Niciu MJ, 2012, PHARMACOL BIOCHEM BE, V100, P656, DOI 10.1016/j.pbb.2011.08.008
   Ogyu K, 2018, NEUROSCI BIOBEHAV R, V90, P16, DOI 10.1016/j.neubiorev.2018.03.023
   Olson JK, 2004, J IMMUNOL, V173, P3916, DOI 10.4049/jimmunol.173.6.3916
   Pimentel GD, 2014, MOL CELL ENDOCRINOL, V397, P15, DOI 10.1016/j.mce.2014.06.005
   Rahman MH, 2018, BIOCH PHARM
   Ropelle ER, 2010, PLOS BIOL, V8, DOI 10.1371/journal.pbio.1000465
   Sawicki CM, 2015, NEUROSCIENCE, V302, P151, DOI 10.1016/j.neuroscience.2014.10.004
   Shelton RC, 2011, MOL PSYCHIATR, V16, P751, DOI 10.1038/mp.2010.52
   SHINTANI F, 1993, J NEUROSCI, V13, P3574
   Silverman MN, 2005, VIRAL IMMUNOL, V18, P41, DOI 10.1089/vim.2005.18.41
   Slavich GM, 2014, PSYCHOL BULL, V140, P774, DOI 10.1037/a0035302
   Sudheimer K, 2015, NEUROPSYCHOPHARMACOL, V40, P849, DOI 10.1038/npp.2014.259
   Tafet GE, 2016, J NEUROPSYCH CLIN N, V28, P77, DOI 10.1176/appi.neuropsych.15030053
   Tatomir Alexandru, 2014, Clujul Med, V87, P3, DOI 10.15386/cjm.2014.8872.871.at1cm2
   Trebatická J, 2017, CHILD ADOL PSYCH MEN, V11, DOI 10.1186/s13034-017-0167-2
   Valdearcos M, 2015, ANNU REV PHYSIOL, V77, P131, DOI 10.1146/annurev-physiol-021014-071656
   Varghese Femina P., 2001, Prim Care Companion J Clin Psychiatry, V3, P151
   Viatour P, 2005, TRENDS BIOCHEM SCI, V30, P43, DOI 10.1016/j.tibs.2004.11.009
   Webster JC, 2001, P NATL ACAD SCI USA, V98, P6865, DOI 10.1073/pnas.121455098
   Wohleb ES, 2012, PSYCHONEUROENDOCRINO, V37, P1491, DOI 10.1016/j.psyneuen.2012.02.003
   Wohleb ES, 2011, J NEUROSCI, V31, P6277, DOI 10.1523/JNEUROSCI.0450-11.2011
   Zhang YX, 2018, J CLIN NEUROSCI, V47, P1, DOI 10.1016/j.jocn.2017.09.022
NR 64
TC 47
Z9 49
U1 0
U2 16
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0967-5868
EI 1532-2653
J9 J CLIN NEUROSCI
JI J. Clin. Neurosci.
PD MAY
PY 2020
VL 75
BP 5
EP 10
DI 10.1016/j.jocn.2020.03.005
PG 6
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA LG7IU
UT WOS:000528270700002
PM 32217047
DA 2025-06-11
ER

PT J
AU Shao, D
   Oka, SI
   Liu, T
   Zhai, P
   Ago, T
   Sciarretta, S
   Li, H
   Sadoshima, J
AF Shao, Dan
   Oka, Shin-ichi
   Liu, Tong
   Zhai, Peiyong
   Ago, Tetsuro
   Sciarretta, Sebastiano
   Li, Hong
   Sadoshima, Junichi
TI A Redox-Dependent Mechanism for Regulation of AMPK Activation by
   Thioredoxin1 during Energy Starvation
SO CELL METABOLISM
LA English
DT Article
ID PROTEIN-KINASE; OXIDATIVE STRESS; MYOCARDIAL-ISCHEMIA;
   CARDIAC-HYPERTROPHY; METABOLIC SYNDROME; APOPTOSIS; AUTOPHAGY; PREVENTS;
   PATHWAY; DISEASE
AB 5'-AMP-activated protein kinase (AMPK) is a key regulator of metabolism and survival during energy stress. Dysregulation of AMPK is strongly associated with oxidative-stress-related disease. However, whether and how AMPK is regulated by intracellular redox status remains unknown. Here we show that the activity of AMPK is negatively regulated by oxidation of Cys130 and Cys174 in its a subunit, which interferes with the interaction between AMPK and AMPK kinases (AMPKK). Reduction of Cys130/Cys174 is essential for activation of AMPK during energy starvation. Thioredoxin1 (Trx1), an important reducing enzyme that cleaves disulfides in proteins, prevents AMPK oxidation, serving as an essential cofactor for AMPK activation. High-fat diet consumption downregulates Trx1 and induces AMPK oxidation, which enhances cardiomyocyte death during myocardial ischemia. Thus, Trx1 modulates activation of the cardioprotective AMPK pathway during ischemia, functionally linking oxidative stress and metabolism in the heart.
C1 [Shao, Dan; Oka, Shin-ichi; Zhai, Peiyong; Ago, Tetsuro; Sciarretta, Sebastiano; Sadoshima, Junichi] Rutgers Biomed & Hlth Sci, Dept Cell Biol & Mol Med, Cardiovasc Res Inst, New Jersey Med Sch, Newark, NJ 07103 USA.
   [Liu, Tong; Li, Hong] Rutgers Biomed & Hlth Sci, Ctr Adv Prote Res, Newark, NJ 07103 USA.
   [Liu, Tong; Li, Hong] Rutgers Biomed & Hlth Sci, Dept Biochem & Mol Biol, Ctr Canc, New Jersey Med Sch, Newark, NJ 07103 USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences; Rutgers University System;
   Rutgers University New Brunswick; Rutgers University Biomedical & Health
   Sciences; Rutgers University System; Rutgers University New Brunswick;
   Rutgers University Biomedical & Health Sciences
RP Sadoshima, J (corresponding author), Rutgers Biomed & Hlth Sci, Dept Cell Biol & Mol Med, Cardiovasc Res Inst, New Jersey Med Sch, Newark, NJ 07103 USA.
EM sadoshju@njms.rutgers.edu
RI Li, Hong/K-8436-2013; Sciarretta, Sebastiano/K-5161-2016
OI Li, Hong/0000-0001-5731-5335; Sadoshima, Junichi/0000-0003-3724-4132;
   Ago, Tetsuro/0000-0003-4560-6594; Sciarretta,
   Sebastiano/0000-0002-8633-6896
FU U.S. Public Health Service [HL67724, HL91469, HL102738, HL112330,
   AG23039]; Foundation of Leducq Transatlantic Network of Excellence; NIH
   [NS046593]
FX We thank Daniela Zablocki and Christopher D. Brady for critical reading
   of the manuscript. This work was supported in part by U.S. Public Health
   Service Grants HL67724, HL91469, HL102738, HL112330, and AG23039 (J.S.)
   and the Foundation of Leducq Transatlantic Network of Excellence (J.S.).
   The Orbitrap mass spectrometer used in this study is supported in part
   by NIH grant NS046593 (H. L.) for the support of a New Jersey Medical
   School Cancer Center Neuroproteomics Core Facility, Rutgers Biomedical
   and Health Sciences.
CR Abdulla J, 2008, EUR HEART J, V29, P594, DOI 10.1093/eurheartj/ehn010
   Ago T, 2008, CELL, V133, P978, DOI 10.1016/j.cell.2008.04.041
   Arner E.S., 1995, J BIOL CHEM, V270, P3479
   Berndt C, 2007, AM J PHYSIOL-HEART C, V292, pH1227, DOI 10.1152/ajpheart.01162.2006
   Cao C, 2008, J BIOL CHEM, V283, P28897, DOI 10.1074/jbc.M804144200
   Dolinsky VW, 2009, CIRCULATION, V119, P1643, DOI 10.1161/CIRCULATIONAHA.108.787440
   Finkel T, 2003, CURR OPIN CELL BIOL, V15, P247, DOI 10.1016/S0955-0674(03)00002-4
   Fu CX, 2009, MOL CELL PROTEOMICS, V8, P1674, DOI 10.1074/mcp.M800580-MCP200
   Han YY, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015420
   Hardie DG, 2008, FEBS LETT, V582, P81, DOI 10.1016/j.febslet.2007.11.018
   Hawley SA, 1996, J BIOL CHEM, V271, P27879, DOI 10.1074/jbc.271.44.27879
   Hisabori T, 2005, J EXP BOT, V56, P1463, DOI 10.1093/jxb/eri170
   KALLIS GB, 1980, J BIOL CHEM, V255, P261
   Kuster GM, 2005, CIRCULATION, V111, P1192, DOI 10.1161/01.CIR.0000157148.59308.F5
   Lillig CH, 2007, ANTIOXID REDOX SIGN, V9, P25, DOI 10.1089/ars.2007.9.25
   Mustacich D, 2000, BIOCHEM J, V346, P1, DOI 10.1042/0264-6021:3460001
   Nayak V, 2006, STRUCTURE, V14, P477, DOI 10.1016/j.str.2005.12.008
   Oakhill JS, 2011, SCIENCE, V332, P1433, DOI 10.1126/science.1200094
   Qin J, 2000, ANTIOXID REDOX SIGN, V2, P827, DOI 10.1089/ars.2000.2.4-827
   Reznick RM, 2007, CELL METAB, V5, P151, DOI 10.1016/j.cmet.2007.01.008
   Russell RR, 2004, J CLIN INVEST, V114, P495, DOI 10.1172/JCI200419297
   Saberi B, 2008, AM J PHYSIOL-CELL PH, V295, pC50, DOI 10.1152/ajpcell.90654.2007
   Saitoh M, 1998, EMBO J, V17, P2596, DOI 10.1093/emboj/17.9.2596
   Sciarretta S, 2013, CIRC RES, V113, P1253, DOI 10.1161/CIRCRESAHA.113.301787
   Sciarretta S, 2012, CIRCULATION, V125, P1134, DOI 10.1161/CIRCULATIONAHA.111.078212
   Sriwijitkamol A, 2007, DIABETES, V56, P836, DOI 10.2337/db06-1119
   Tao L, 2004, P NATL ACAD SCI USA, V101, P11471, DOI 10.1073/pnas.0402941101
   Verdoucq L, 1999, J BIOL CHEM, V274, P19714, DOI 10.1074/jbc.274.28.19714
   Yamamoto M, 2003, J CLIN INVEST, V112, P1395, DOI 10.1172/JCI200317700
   Zmijewski JW, 2010, J BIOL CHEM, V285, P33154, DOI 10.1074/jbc.M110.143685
   Zschauer TC, 2011, ARTERIOSCL THROM VAS, V31, P650, DOI 10.1161/ATVBAHA.110.218982
NR 31
TC 185
Z9 215
U1 2
U2 31
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD FEB 4
PY 2014
VL 19
IS 2
BP 232
EP 245
DI 10.1016/j.cmet.2013.12.013
PG 14
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 304CE
UT WOS:000330722600009
PM 24506865
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Rajakumar, S
   Nachiappan, V
AF Rajakumar, Selvaraj
   Nachiappan, Vasanthi
TI Lipid droplets alleviate cadmium induced cytotoxicity in
   Saccharomyces cerevisiae
SO TOXICOLOGY RESEARCH
LA English
DT Article
ID INDUCED APOPTOSIS; OXIDATIVE STRESS; NEUTRAL LIPIDS; YEAST;
   TRIACYLGLYCEROL; ACYLTRANSFERASE; TOXICITY; CELLS;
   PHOSPHATIDYLETHANOLAMINE; SCHIZOSACCHAROMYCES
AB Cadmium (Cd) induces oxidative stress that generates reactive oxygen species (ROS) and increased lipid accumulation. However, very little is known about the role of oxidative stress in triacylglycerol (TAG) accumulation. TAG accumulation is deleterious to health and may result in obesity-associated metabolic syndrome. Hence TAG accumulation plays an important role in Cd induced cytotoxicity. The exposure of Wild-type (WT) cells to Cd, resulted in TAG accumulation and also enhanced viability when compared to TAG mutants (dga1 Delta, lro1 Delta and are2 Delta). The inhibition of lipolysis also increased the tolerance of the cells to Cd. Fluorescence microscopy observations using acridine orange and DHR123 staining demonstrated that the TAG deficient mutants showed enhanced cell death and ROS production. The over expression of DGA1 and LRO1 rescued the Cd induced cytotoxicity by enhancing the formation of LDs. Results of this study revealed the possible metabolic link between LDs and oxidative stress in S. cerevisiae.
C1 [Rajakumar, Selvaraj; Nachiappan, Vasanthi] Bharathidasan Univ, Biomembrane Lab, Dept Biochem, Ctr Excellence Life Sci, Tiruchirappalli 620024, Tamil Nadu, India.
C3 Bharathidasan University
RP Nachiappan, V (corresponding author), Bharathidasan Univ, Biomembrane Lab, Dept Biochem, Ctr Excellence Life Sci, Tiruchirappalli 620024, Tamil Nadu, India.
EM vasanthibch@gmail.com
RI Selvaraj, Rajakumar/AAO-6358-2020
OI Nachiappan, Vasanthi/0000-0001-9891-3657
FU Rajiv Gandhi National Fellowship Scheme from UGC, India
FX Infrastructure facility by DST-FIST, Biochemistry Department and
   confocal microscopy facility by DST-PURSE at Bharathidasan University is
   gratefully acknowledged. SR is supported by a fellowship from the Rajiv
   Gandhi National Fellowship Scheme from UGC, India. We thank Prof. Ram
   Rajasekharan, CSIR-CFTRI, Mysore, India, Prof. Daum Gunther, Dr K.
   Athenstaedt, University of Graz, Austria, and Prof. Sten. Stymne,
   Germany, for providing mutant strains for this work. We also acknowledge
   Central Instruments Facility and Services (CIFS), CFTRI, Mysore, India
   for helping us to conduct the GC-MS study.
CR Athenstaedt K, 2005, J BIOL CHEM, V280, P37301, DOI 10.1074/jbc.M507261200
   Athenstaedt K, 2003, J BIOL CHEM, V278, P23317, DOI 10.1074/jbc.M302577200
   Baskic D, 2006, CELL BIOL INT, V30, P924, DOI 10.1016/j.cellbi.2006.06.016
   Belyaeva EA, 2003, TOXICOL APPL PHARM, V192, P56, DOI 10.1016/S0041-008X(03)00255-2
   BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911
   Carmona-Gutierrez D, 2010, CELL DEATH DIFFER, V17, P763, DOI 10.1038/cdd.2009.219
   Czabany T, 2007, BBA-MOL CELL BIOL L, V1771, P299, DOI 10.1016/j.bbalip.2006.07.001
   Dahlqvist A, 2000, P NATL ACAD SCI USA, V97, P6487, DOI 10.1073/pnas.120067297
   Daum G, 2007, BIOCHIMIE, V89, P243, DOI 10.1016/j.biochi.2006.06.018
   Duke RC, 1996, SCI AM, V275, P80, DOI 10.1038/scientificamerican1296-80
   Fakas S, 2011, J BIOL CHEM, V286, P1464, DOI 10.1074/jbc.M110.194308
   Feng B, 2003, P NATL ACAD SCI USA, V100, P10423, DOI 10.1073/pnas.1732494100
   Ferreira TC, 2011, FEMS YEAST RES, V11, P408, DOI 10.1111/j.1567-1364.2011.00729.x
   Fujimoto T, 2008, HISTOCHEM CELL BIOL, V130, P263, DOI 10.1007/s00418-008-0449-0
   Garbarino J, 2009, J BIOL CHEM, V284, P30994, DOI 10.1074/jbc.M109.050443
   Holland WL, 2007, CELL METAB, V5, P167, DOI 10.1016/j.cmet.2007.01.002
   Horvath SE, 2011, BBA-MOL CELL BIOL L, V1811, P1030, DOI 10.1016/j.bbalip.2011.08.007
   Kalantari F, 2010, MOL MEMBR BIOL, V27, P462, DOI 10.3109/09687688.2010.538936
   Kurat CF, 2006, J BIOL CHEM, V281, P491, DOI 10.1074/jbc.M508414200
   Lemarié A, 2004, FREE RADICAL BIO MED, V36, P1517, DOI 10.1016/j.freeradbiomed.2004.03.020
   Ligr M, 1998, FEBS LETT, V438, P61, DOI 10.1016/S0014-5793(98)01227-7
   Listenberger LL, 2001, J BIOL CHEM, V276, P14890, DOI 10.1074/jbc.M010286200
   Nguyen LN, 2011, CELL CYCLE, V10, DOI 10.4161/cc.10.18.16932
   Low CP, 2005, FEMS YEAST RES, V5, P1199, DOI 10.1016/j.femsyr.2005.07.004
   Madeo F, 1997, J CELL BIOL, V139, P729, DOI 10.1083/jcb.139.3.729
   Manon S, 2004, ANTIOXID REDOX SIGN, V6, P259, DOI 10.1089/152308604322899323
   Marone Maria, 2001, Biological Procedures Online, V3, P19, DOI 10.1251/bpo20
   MORRISON WR, 1964, J LIPID RES, V5, P600
   MULLER L, 1986, TOXICOLOGY, V40, P285, DOI 10.1016/0300-483X(86)90061-2
   Muthukumar K, 2013, CELL BIOCHEM BIOPHYS, V67, P1353, DOI 10.1007/s12013-013-9667-8
   Muthukumar K, 2011, ANTON LEEUW INT J G, V99, P761, DOI 10.1007/s10482-011-9550-9
   Newairy AA, 2007, TOXICOLOGY, V242, P23, DOI 10.1016/j.tox.2007.09.001
   Oelkers P, 2000, J BIOL CHEM, V275, P15609, DOI 10.1074/jbc.C000144200
   Oelkers P, 2002, J BIOL CHEM, V277, P8877, DOI 10.1074/jbc.M111646200
   Petschnigg J, 2009, J BIOL CHEM, V284, P30981, DOI 10.1074/jbc.M109.024752
   Rockenfeller P, 2010, CELL CYCLE, V9, P2836, DOI 10.4161/cc.9.14.12346
   Schmidt C, 2014, BBA-MOL CELL BIOL L, V1841, P1393, DOI 10.1016/j.bbalip.2014.07.001
   Sheibani S, 2014, CELL CYCLE, V13, P138, DOI 10.4161/cc.26885
   Shivapurkar N, 2003, J CELL BIOCHEM, V88, P885, DOI 10.1002/jcb.10440
   Sorger D, 2002, J BACTERIOL, V184, P519, DOI 10.1128/JB.184.2.519-524.2002
   Vandenabeele S, 2004, PLANT J, V39, P45, DOI 10.1111/j.1365-313X.2004.02105.x
   Wang CW, 2015, CELL MOL LIFE SCI, V72, P2677, DOI 10.1007/s00018-015-1903-5
   Wang JC, 2014, J VET SCI, V15, P485, DOI 10.4142/jvs.2014.15.4.485
   Wolinski Heimo, 2008, V457, P151, DOI 10.1007/978-1-59745-261-8_11
   Zhang Q, 2003, J BIOL CHEM, V278, P47145, DOI 10.1074/jbc.M306998200
NR 45
TC 9
Z9 10
U1 2
U2 13
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2045-452X
EI 2045-4538
J9 TOXICOL RES-UK
JI Toxicol. Res.
PD JAN 1
PY 2017
VL 6
IS 1
BP 30
EP 41
DI 10.1039/c6tx00187d
PG 12
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA EI9GZ
UT WOS:000392817200003
PM 30090475
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Sutin, AR
   Terracciano, A
   Deiana, B
   Uda, M
   Schlessinger, D
   Lakatta, EG
   Costa, PT
AF Sutin, Angelina R.
   Terracciano, Antonio
   Deiana, Barbara
   Uda, Manuela
   Schlessinger, David
   Lakatta, Edward G.
   Costa, Paul T., Jr.
TI Cholesterol, triglycerides, and the Five-Factor Model of personality
SO BIOLOGICAL PSYCHOLOGY
LA English
DT Article
DE Personality; Depression; Impulsivity; Cholesterol; Triglycerides
ID CORONARY-HEART-DISEASE; NEO-PI-R; MIDDLE-AGED MEN; DEPRESSIVE SYMPTOMS;
   METABOLIC SYNDROME; YOUNG-ADULTS; A-BEHAVIOR; SERUM-CHOLESTEROL;
   HOSTILITY; TRAITS
AB Unhealthy lipid levels are among the leading controllable risk factors for coronary heart disease. To identify the psychological factors associated with dyslipidemia, this study investigates the personality correlates of cholesterol (total, LDL, and HDL) and triglycerides. A community-based sample (N = 5532) from Sardinia, Italy, had their cholesterol and triglyceride levels assessed and completed a comprehensive personality questionnaire, the NEO-PI-R. All analyses controlled for age, sex, BMI, smoking, drinking, hypertension, and diabetes. Low Conscientiousness and traits related to impulsivity were associated with lower HDL cholesterol and higher triglycerides. Compared to the lowest 10%, those who scored in top 10% on Impulsivity had a 2.5 times greater risk of exceeding the clinical threshold for elevated triglycerides (OR = 2.51, CI = 1.56-4.07). In addition, sex moderated the association between trait depression (a component of Neuroticism) and HDL cholesterol, such that trait depression was associated with lower levels of HDL cholesterol in women but not men. When considering the connection between personality and health, unhealthy lipid profiles may be one intermediate biomarker between personality and morbidity and mortality. Published by Elsevier B.V.
C1 [Sutin, Angelina R.] NIA, Lab Personal & Cognit, NIH, DHHS, Baltimore, MD 21224 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA)
RP Sutin, AR (corresponding author), NIA, Lab Personal & Cognit, NIH, DHHS, 251 Bayview Blvd, Baltimore, MD 21224 USA.
EM sutina@mail.nih.gov
RI Lakatta, Edward/AAL-1447-2020; Uda, Manuela/AAC-2645-2019; Costa,
   Paul/AAH-6594-2019; Terracciano, Antonio/H-7403-2019
OI Terracciano, Antonio/0000-0001-5799-8885; Costa,
   Paul/0000-0003-4375-1712; UDA, MANUELA/0000-0002-4890-6456; Lakatta,
   Edward/0000-0002-4772-0035
FU NIH; National Institute on Aging
FX This research was supported in part by the Intramural Research Program
   of the NIH, National Institute on Aging. Paul Costa receives royalties
   from the Revised NEO Personality Inventory.
CR Aiken LS., 1991, Multiple regression: Testing and interpreting interactions
   ALMADA SJ, 1991, PSYCHOSOM MED, V53, P165, DOI 10.1097/00006842-199103000-00006
   *ASS AH, 2001, 2000 HEART STROK STA
   Atmaca M, 2002, NEUROPSYCHOBIOLOGY, V45, P167, DOI 10.1159/000063665
   Avorn J, 1998, JAMA-J AM MED ASSOC, V279, P1458, DOI 10.1001/jama.279.18.1458
   Beasley CL, 2005, BIPOLAR DISORD, V7, P449, DOI 10.1111/j.1399-5618.2005.00239.x
   Benjamin Lily, 2005, Eat Behav, V6, P197, DOI 10.1016/j.eatbeh.2003.08.001
   BOOTHKEWLEY S, 1987, PSYCHOL BULL, V101, P343, DOI 10.1037/0033-2909.101.3.343
   Chapman BP, 2007, PSYCHOSOM MED, V69, P277, DOI 10.1097/PSY.0b013e3180313975
   Chen CC, 2001, PSYCHIAT RES, V102, P153, DOI 10.1016/S0165-1781(01)00231-1
   Chida Y, 2009, J AM COLL CARDIOL, V53, P936, DOI 10.1016/j.jacc.2008.11.044
   Costa P., 1992, Revised NEO Personality Inventory (NEOPIR) and NEO FiveFactor Inventory (NEOFFI) professional manual
   Costa PT, 2007, BEHAV GENET, V37, P376, DOI 10.1007/s10519-006-9103-6
   DEMBROSKI TM, 1989, PSYCHOSOM MED, V51, P514, DOI 10.1097/00006842-198909000-00003
   FEINGOLD KR, 1992, DIABETES, V41, P97, DOI 10.2337/diab.41.2.S97
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Giltay EJ, 2009, J AFFECT DISORDERS, V115, P471, DOI 10.1016/j.jad.2008.10.004
   Goodwin RD, 2006, J HEALTH PSYCHOL, V11, P643, DOI 10.1177/1359105306066610
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Herva A, 2006, PSYCHOSOM MED, V68, P213, DOI 10.1097/01.psy.0000203172.02305.ea
   Horsten M, 1997, PSYCHOSOM MED, V59, P521, DOI 10.1097/00006842-199709000-00009
   Hoyt AL, 2009, PSYCHOL SPORT EXERC, V10, P565, DOI 10.1016/j.psychsport.2009.02.008
   Ikeda A, 2008, INT J EPIDEMIOL, V37, P1395, DOI 10.1093/ije/dyn124
   Jow GM, 2006, J AFFECT DISORDERS, V90, P21, DOI 10.1016/j.jad.2005.09.015
   Kern ML, 2008, HEALTH PSYCHOL, V27, P505, DOI 10.1037/0278-6133.27.5.505
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Liberopoulos EN, 2008, EXPERT OPIN DRUG SAF, V7, P717, DOI [10.1517/14740330802396984, 10.1517/14740330802396984 ]
   Löckenhoff CE, 2008, J RES PERS, V42, P1334, DOI 10.1016/j.jrp.2008.05.006
   McCaffery JM, 2003, PSYCHOSOM MED, V65, P490, DOI 10.1097/01.PSY.0000041545.52924.82
   McCrae R.R., 2003, Personality in adulthood, V2nd
   McCrae RR, 2002, J PERS SOC PSYCHOL, V83, P1456, DOI 10.1037//0022-3514.83.6.1456
   Nabi H, 2008, INT J EPIDEMIOL, V37, P386, DOI 10.1093/ije/dyn013
   Pilia G, 2006, PLOS GENET, V2, P1207, DOI 10.1371/journal.pgen.0020132
   Rhodes RE, 2006, BRIT J SPORT MED, V40, P958, DOI 10.1136/bjsm.2006.028860
   Richards JC, 2000, HEALTH PSYCHOL, V19, P393, DOI 10.1037//0278-6133.19.4.393
   Rush CC, 2009, PSYCHOL ADDICT BEHAV, V23, P140, DOI 10.1037/a0013167
   Saliba AJ, 2009, FOOD QUAL PREFER, V20, P572, DOI 10.1016/j.foodqual.2009.05.009
   SCHERWITZ LW, 1992, AM J EPIDEMIOL, V136, P136, DOI 10.1093/oxfordjournals.aje.a116480
   SHEKELLE RB, 1985, AM J EPIDEMIOL, V122, P559, DOI 10.1093/oxfordjournals.aje.a114135
   Shin JY, 2008, ANN BEHAV MED, V36, P33, DOI 10.1007/s12160-008-9045-8
   Shively CA, 2008, PSYCHOSOM MED, V70, P637, DOI 10.1097/PSY.0b013e31817eaf0b
   Simons LA, 1996, MED J AUSTRALIA, V164, P208, DOI 10.5694/j.1326-5377.1996.tb94138.x
   SMITH TW, 1992, HEALTH PSYCHOL, V11, P139, DOI 10.1037/0278-6133.11.3.139
   Steegmans PHA, 2000, PSYCHOSOM MED, V62, P205, DOI 10.1097/00006842-200003000-00009
   Stewart RA, 2000, ARCH INTERN MED, V160, P3144, DOI 10.1001/archinte.160.20.3144
   Stilley CS, 2004, ANN BEHAV MED, V27, P117, DOI 10.1207/s15324796abm2702_6
   Suarez EC, 1999, PSYCHOSOM MED, V61, P273, DOI 10.1097/00006842-199905000-00004
   Sutin AR, 2010, PSYCHOL MED, V40, P1485, DOI 10.1017/S0033291709992029
   Terracciano A, 2005, PSYCHOL AGING, V20, P493, DOI 10.1037/0882-7974.20.3.493
   Terracciano A, 2004, ADDICTION, V99, P472, DOI 10.1111/j.1360-0443.2004.00687.x
   Terracciano A, 2003, PERS INDIV DIFFER, V35, P1859, DOI 10.1016/S0191-8869(03)00035-7
   Terracciano A, 2008, BMC PSYCHIATRY, V8, DOI 10.1186/1471-244X-8-22
   Terracciano A, 2008, PSYCHOSOM MED, V70, P621, DOI 10.1097/PSY.0b013e31817b9371
   Terracciano A, 2009, PSYCHOSOM MED, V71, P682, DOI 10.1097/PSY.0b013e3181a2925b
   Toker S, 2008, DEPRESS ANXIETY, V25, P661, DOI 10.1002/da.20379
   Troisi A, 2009, NEUROSCI BIOBEHAV R, V33, P125, DOI 10.1016/j.neubiorev.2008.09.003
   Whiteside SP, 2001, PERS INDIV DIFFER, V30, P669, DOI 10.1016/S0191-8869(00)00064-7
   WILLIAMS RB, 1980, PSYCHOSOM MED, V42, P539, DOI 10.1097/00006842-198011000-00002
   Wilson RS, 2004, J GERONTOL B-PSYCHOL, V59, pP110, DOI 10.1093/geronb/59.3.P110
   Young-Xu Y, 2003, J AM COLL CARDIOL, V42, P690, DOI 10.1016/S0735-1097(03)00785-X
NR 60
TC 79
Z9 83
U1 2
U2 25
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0301-0511
EI 1873-6246
J9 BIOL PSYCHOL
JI Biol. Psychol.
PD MAY
PY 2010
VL 84
IS 2
BP 186
EP 191
DI 10.1016/j.biopsycho.2010.01.012
PG 6
WC Psychology, Biological; Behavioral Sciences; Psychology; Psychology,
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA 616GQ
UT WOS:000279197500004
PM 20109519
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Vrany, EA
   Berntson, JM
   Khambaty, T
   Stewart, JC
AF Vrany, Elizabeth A.
   Berntson, Jessica M.
   Khambaty, Tasneem
   Stewart, Jesse C.
TI Depressive Symptoms Clusters and Insulin Resistance: Race/Ethnicity as a
   Moderator in 2005-2010 NHANES Data
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Depression; Depressive symptom clusters; Insulin resistance; Diabetes;
   Race/ethnicity; NHANES
ID HOMEOSTASIS MODEL ASSESSMENT; PATIENT HEALTH QUESTIONNAIRE; TYPE-2
   DIABETES-MELLITUS; ARTERY RISK DEVELOPMENT; C-REACTIVE PROTEIN;
   METABOLIC SYNDROME; DIFFERENTIAL ASSOCIATION; COGNITIVE SYMPTOMS;
   RESIDUAL SYMPTOMS; MAJOR DEPRESSION
AB Background Although depression has been linked to insulin resistance, few studies have examined depressive symptom clusters.
   Purpose We examined whether certain depressive symptom clusters are more strongly associated with insulin resistance in a nationally representative sample, and we evaluated potential moderators and mediators.
   Methods Respondents were 4487 adults from NHANES 2005-2010. Depressive symptoms were measured with the Patient Health Questionnaire-9 (PHQ-9), and insulin resistance was indexed by the homeostatic model assessment (HOMA) score.
   Results Positive relationships between PHQ-9 total, somatic, and cognitive-affective scores and HOMA score were detected (ps <0.001). In a simultaneous model, the somatic (p= 0.017), but not the cognitive-affective (p= 0.071), score remained associated with HOMA score. We observed evidence of (a) moderation by race/ethnicity (relationships stronger in non-Hispanic Whites) and (b) mediation by body mass and inflammation.
   Conclusions The depressive symptoms-insulin resistance link may be strongest among non-Hispanic Whites and may be driven slightly more by the somatic symptoms.
C1 [Vrany, Elizabeth A.; Berntson, Jessica M.; Khambaty, Tasneem; Stewart, Jesse C.] Indiana Univ Purdue Univ, Dept Psychol, 402 North Blackford St,LD 100E, Indianapolis, IN 46202 USA.
C3 Purdue University System; Purdue University; Purdue University in
   Indianapolis
RP Stewart, JC (corresponding author), Indiana Univ Purdue Univ, Dept Psychol, 402 North Blackford St,LD 100E, Indianapolis, IN 46202 USA.
EM jstew@iupui.edu
RI Khambaty, Tasneem/JED-6735-2023
OI Vrany, Elizabeth/0000-0003-1452-705X
CR Amer Diabet Assoc, 2009, DIABETES CARE, V32, pS62, DOI [10.2337/dc09-S062, 10.2337/dc10-s062]
   Austin AW, 2014, DIABETIC MED, V31, P994, DOI 10.1111/dme.12465
   Baliunas DO, 2009, DIABETES CARE, V32, P2123, DOI 10.2337/dc09-0227
   Barbour LA, 2007, DIABETES CARE, V30, pS112, DOI 10.2337/dc07-s202
   Blaine B, 2008, J HEALTH PSYCHOL, V13, P1190, DOI 10.1177/1359105308095977
   Bonora E, 2000, DIABETES CARE, V23, P57, DOI 10.2337/diacare.23.1.57
   Bunt JC, 2007, DIABETES-METAB RES, V23, P304, DOI 10.1002/dmrr.686
   Cameron IM, 2011, BRIT J GEN PRACT, V61, DOI 10.3399/bjgp11X583209
   Carney RM, 2012, PSYCHOSOM MED, V74, P33, DOI 10.1097/PSY.0b013e3182405ac4
   Case SM, 2014, BRAIN BEHAV IMMUN, V41, P101, DOI 10.1016/j.bbi.2014.04.004
   Chilcot J, 2013, J PSYCHOSOM RES, V75, P60, DOI 10.1016/j.jpsychores.2012.12.012
   Conradi HJ, 2011, PSYCHOL MED, V41, P1165, DOI 10.1017/S0033291710001911
   Davidson KW, 2005, PSYCHOSOM MED, V67, pS6, DOI 10.1097/01.psy.0000162257.19266.fc
   De Jonge P, 2007, PSYCHOSOM MED, V69, P735, DOI 10.1097/PSY.0b013e31815743ca
   Deverts DJ, 2010, PSYCHOSOM MED, V72, P734, DOI 10.1097/PSY.0b013e3181ec4b98
   Duivis HE, 2013, PSYCHONEUROENDOCRINO, V38, P1573, DOI 10.1016/j.psyneuen.2013.01.002
   Eliasson B, 2003, PROG CARDIOVASC DIS, V45, P405, DOI 10.1053/pcad.2003.00103
   Esteghamati A, 2010, NUTR METAB, V7, DOI 10.1186/1743-7075-7-26
   Everson-Rose SA, 2004, DIABETES CARE, V27, P2856, DOI 10.2337/diacare.27.12.2856
   Fisher L, 2008, DIABETIC MED, V25, P1096, DOI 10.1111/j.1464-5491.2008.02533.x
   Fisher L, 2014, DIABETIC MED, V31, P764, DOI 10.1111/dme.12428
   Freedland KE, 2005, PSYCHOSOM MED, V67, pS42, DOI 10.1097/01.psy.0000162255.55629.9c
   Gallagher EJ, 2008, ENDOCRIN METAB CLIN, V37, P559, DOI 10.1016/j.ecl.2008.05.002
   Ginsberg HN, 2000, J CLIN INVEST, V106, P453, DOI 10.1172/JCI10762
   Golden SH, 2007, CURR DIABETES REV, V3, P252, DOI 10.2174/157339907782330021
   Golden SH, 2008, JAMA-J AM MED ASSOC, V299, P2751, DOI 10.1001/jama.299.23.2751
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Huang FY, 2006, J GEN INTERN MED, V21, P547, DOI 10.1111/j.1525-1497.2006.00409.x
   Hybels CF, 2005, INT J GERIATR PSYCH, V20, P1196, DOI 10.1002/gps.1418
   Ismail K., 2010, DEPRESSION DIABETES
   Kahn SE, 2006, NATURE, V444, P840, DOI 10.1038/nature05482
   Kan C, 2013, DIABETES CARE, V36, P480, DOI 10.2337/dc12-1442
   Katon W, 2008, J GEN INTERN MED, V23, P1571, DOI 10.1007/s11606-008-0731-9
   Khambaty T, 2014, PSYCHOSOM MED, V76, P363, DOI 10.1097/PSY.0000000000000063
   Kiecolt-Glaser JK, 2002, J PSYCHOSOM RES, V53, P873, DOI 10.1016/S0022-3999(02)00309-4
   Knol MJ, 2006, DIABETOLOGIA, V49, P837, DOI 10.1007/s00125-006-0159-x
   Krause JS, 2008, REHABIL PSYCHOL, V53, P513, DOI 10.1037/a0013354
   Kroenke K, 2002, PSYCHIAT ANN, V32, P509, DOI 10.3928/0048-5713-20020901-06
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Liao MT, 2012, J BIOMED BIOTECHNOL, DOI 10.1155/2012/691369
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Manea L, 2012, CAN MED ASSOC J, V184, pE191, DOI 10.1503/cmaj.110829
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Michal M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0072014
   Miranda PJ, 2005, AM HEART J, V149, P33, DOI 10.1016/j.ahj.2004.07.013
   Nouwen A, 2010, DIABETOLOGIA, V53, P2480, DOI 10.1007/s00125-010-1874-x
   Patten SB, 2009, COMPR PSYCHIAT, V50, P26, DOI 10.1016/j.comppsych.2008.05.012
   Raison CL, 2006, TRENDS IMMUNOL, V27, P24, DOI 10.1016/j.it.2005.11.006
   Reinehr T, 2004, HORM RES, V62, P107, DOI 10.1159/000079841
   Renn BN, 2011, CLIN PSYCHOL REV, V31, P1239, DOI 10.1016/j.cpr.2011.08.001
   Roy T, 2012, J AFFECT DISORDERS, V142, pS8, DOI 10.1016/S0165-0327(12)70004-6
   Rustad JK, 2011, PSYCHONEUROENDOCRINO, V36, P1276, DOI 10.1016/j.psyneuen.2011.03.005
   Ryan JP, 2012, PSYCHOSOM MED, V74, P476, DOI 10.1097/PSY.0b013e31824d0865
   Shepherd PR, 1999, NEW ENGL J MED, V341, P248, DOI 10.1056/NEJM199907223410406
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Silva N, 2012, CURR PSYCHIAT REP, V14, P8, DOI 10.1007/s11920-011-0245-8
   Stewart JC, 2012, CIRCULATION, V126, P410, DOI 10.1161/CIRCULATIONAHA.112.094946
   Stewart JC, 2009, BRAIN BEHAV IMMUN, V23, P936, DOI 10.1016/j.bbi.2009.04.011
   Sullivan LE, 2005, AM J MED, V118, P330, DOI 10.1016/j.amjmed.2005.01.007
   Twist K, 2013, PSYCHOSOM MED, V75, P791, DOI 10.1097/PSY.0b013e3182a2b108
   Utzschneider KM, 2006, J CLIN ENDOCR METAB, V91, P4753, DOI 10.1210/jc.2006-0587
   Van der Kooy K, 2007, INT J GERIATR PSYCH, V22, P613, DOI 10.1002/gps.1723
   Vgontzas AN, 2006, ANN NY ACAD SCI, V1083, P329, DOI 10.1196/annals.1367.023
   Wallace TM, 2004, DIABETES CARE, V27, P1487, DOI 10.2337/diacare.27.6.1487
   Wallace TM, 2002, DIABETIC MED, V19, P527, DOI 10.1046/j.1464-5491.2002.00745.x
   Wiltink J, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-223
   Wittkampf KA, 2007, GEN HOSP PSYCHIAT, V29, P388, DOI 10.1016/j.genhosppsych.2007.06.004
   Yin JH, 2013, DIABETOL METAB SYNDR, V5, DOI 10.1186/1758-5996-5-71
NR 69
TC 21
Z9 24
U1 1
U2 10
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD FEB
PY 2016
VL 50
IS 1
BP 1
EP 11
DI 10.1007/s12160-015-9725-0
PG 11
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA DI6VU
UT WOS:000373639100001
PM 26318593
OA Bronze
DA 2025-06-11
ER

PT J
AU Salimi, Z
   Rostami, M
   Milasi, YE
   Mafi, A
   Raoufinia, R
   Kiani, A
   Sakhaei, F
   Ghezelbash, B
   Butler, AE
   Mohammad-Sadeghipour, M
   Sahebkar, A
AF Salimi, Zohreh
   Rostami, Mehdi
   Milasi, Yaser Eshaghi
   Mafi, Alireza
   Raoufinia, Ramin
   Kiani, Amirhossein
   Sakhaei, Fariba
   Ghezelbash, Behrooz
   Butler, Alexandra E.
   Mohammad-Sadeghipour, Maryam
   Sahebkar, Amirhossein
TI Unfolded Protein Response Signaling in Hepatic Stem Cell Activation in
   Liver Fibrosis
SO CURRENT PROTEIN & PEPTIDE SCIENCE
LA English
DT Review
DE Stresses; endoplasmic reticulum; hepatic satellite cells; unfolded
   protein response; liver fibrosis; drug therapy
ID ENDOPLASMIC-RETICULUM STRESS; ER-STRESS; OXIDATIVE STRESS; STELLATE
   CELLS; MESSENGER-RNA; MITOCHONDRIAL DYNAMICS; BAX INHIBITOR-1;
   AUTOPHAGY; APOPTOSIS; DEATH
AB Frequent exposure to various external and internal adverse forces (stresses) disrupts ell protein homeostasis through endoplasmic reticulum (ER) capacity saturation. his process leads to the unfolded protein response (UPR), which aims to re-establish/maintain ptimal cellular equilibrium. This complex mechanism is involved in the pathogenesis of various disorders, such as metabolic syndrome, ibrotic diseases, neurodegeneration, and cancer, by altering cellular metabolic changes integral to ctivating the hepatic stellate cells (HSCs). The development of hepatic fibrosis is one of he consequences of UPR activation. Therefore, novel therapies that target the UPR pathway effectively and pecifically are being studied. This article covers the involvement of the UPR signaling pathway in cellular damage in liver fibrosis. Investigating the pathogenic pathways related to the ER/UPR stress axis that contribute to liver fibrosis can help to guide future drug therapy approaches.
C1 [Salimi, Zohreh; Milasi, Yaser Eshaghi; Mafi, Alireza; Sakhaei, Fariba] Isfahan Univ Med Sci, Dept Clin Biochem, Sch Pharm & Pharmaceut Sci, Esfahan, Iran.
   [Rostami, Mehdi] Mashhad Univ Med Sci, Fac Med, Dept Clin Biochem, Mashhad, Iran.
   [Mafi, Alireza] Isfahan Univ Med Sci, Nutr & Food Secur Res Ctr, Esfahan, Iran.
   [Raoufinia, Ramin] Mashhad Univ Med Sci, Sch Med, Med Genet & Mol Med Dept, Mashhad, Iran.
   [Raoufinia, Ramin] Neyshabur Univ Med Sci, Neyshabur, Iran.
   [Kiani, Amirhossein] Ahvaz Jundishapur Univ Med Sci, Fac Med, Dept Immunol, Ahvaz, Iran.
   [Ghezelbash, Behrooz] Isfahan Univ Med Sci, Dept Immunol, Sch Med, Esfahan, Iran.
   [Butler, Alexandra E.] Royal Coll Surg Ireland, Res Dept, POB 15503, Busaiteen, Adliya, Bahrain.
   [Mohammad-Sadeghipour, Maryam] Kerman Univ Med Sci, Afzalipoor Fac Med, Dept Clin Biochem, Kerman, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
C3 Isfahan University of Medical Sciences; Mashhad University of Medical
   Sciences; Isfahan University of Medical Sciences; Mashhad University of
   Medical Sciences; Ahvaz Jundishapur University of Medical Sciences
   (AJUMS); Isfahan University of Medical Sciences; Royal College of
   Surgeons - Ireland; Royal College of Surgeons in Ireland - Medical
   University of Bahrain; Kerman University of Medical Sciences; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences
RP Mohammad-Sadeghipour, M (corresponding author), Kerman Univ Med Sci, Afzalipoor Fac Med, Dept Clin Biochem, Kerman, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
EM M.Sadeghipour65@yahoo.com; amir_saheb2000@yahoo.com
RI Mafi, Alireza/AAT-6866-2021; Mohammad-Sadeghipour, Maryam/AAX-6052-2021;
   Sahebkar, Amirhossein/B-5124-2018
FU Kerman University of Medical Sciences (KUMS) of Iran; Isfahan University
   of Medical Sciences (IUMS), Isfahan, Iran
FX The authors thank the Kerman University of Medical Sciences (KUMS) of
   Iran and Isfahan University of Medical Sciences (IUMS), Isfahan, Iran,
   for their cooperation.
CR Aboutwerat A, 2003, BBA-MOL BASIS DIS, V1637, P142, DOI 10.1016/S0925-4439(02)00225-9
   Adolph TE, 2013, NATURE, V503, P272, DOI 10.1038/nature12599
   Aghaei M, 2021, LIFE-BASEL, V11, DOI 10.3390/life11010001
   Alizadeh J, 2019, METHODS MOL BIOL, V1854, P87, DOI 10.1007/7651_2017_84
   Alizadeh J, 2018, BBA-MOL CELL RES, V1865, P749, DOI 10.1016/j.bbamcr.2018.02.007
   Almanza A, 2019, FEBS J, V286, P241, DOI 10.1111/febs.14608
   Amin-Wetzel N, 2019, ELIFE, V8, DOI 10.7554/eLife.50793
   Anckar J, 2011, ANNU REV BIOCHEM, V80, P1089, DOI 10.1146/annurev-biochem-060809-095203
   Arsène F, 2000, INT J FOOD MICROBIOL, V55, P3, DOI 10.1016/S0168-1605(00)00206-3
   B'chir W, 2013, NUCLEIC ACIDS RES, V41, P7683, DOI 10.1093/nar/gkt563
   Belmont PJ, 2012, J MOL CELL CARDIOL, V52, P1176, DOI 10.1016/j.yjmcc.2012.01.017
   Bertolotti A, 2000, NAT CELL BIOL, V2, P326, DOI 10.1038/35014014
   Bultynck G, 2012, J BIOL CHEM, V287, P2544, DOI 10.1074/jbc.M111.275354
   Carrara M, 2015, ELIFE, V4, DOI 10.7554/eLife.03522
   Casey AK, 2017, J BIOL CHEM, V292, P21193, DOI 10.1074/jbc.M117.799296
   Cavener DR, 2010, TRENDS ENDOCRIN MET, V21, P714, DOI 10.1016/j.tem.2010.08.005
   Cederbaum AI, 2009, ARCH TOXICOL, V83, P519, DOI 10.1007/s00204-009-0432-0
   Chen X, 2021, NAT REV CANCER, V21, P71, DOI 10.1038/s41568-020-00312-2
   Cnop M, 2017, MOL METAB, V6, P1024, DOI 10.1016/j.molmet.2017.06.001
   Cullinan SB, 2006, INT J BIOCHEM CELL B, V38, P317, DOI 10.1016/j.biocel.2005.09.018
   Cullinan SB, 2004, J BIOL CHEM, V279, P20108, DOI 10.1074/jbc.M314219200
   Czaja AJ, 2014, WORLD J GASTROENTERO, V20, P2515, DOI 10.3748/wjg.v20.i10.2515
   Czochra P, 2006, J HEPATOL, V45, P419, DOI 10.1016/j.jhep.2006.04.010
   Dai XZ, 2020, TRENDS MOL MED, V26, P185, DOI 10.1016/j.molmed.2019.09.007
   Darling NJ, 2014, BBA-MOL CELL RES, V1843, P2150, DOI 10.1016/j.bbamcr.2014.01.009
   Dastghaib S, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9112339
   Dastghaib S, 2021, AM J RESP CELL MOL, V64, P29, DOI 10.1165/rcmb.2019-0235TR
   Deegan S, 2013, CELL MOL LIFE SCI, V70, P2425, DOI 10.1007/s00018-012-1173-4
   Delépine M, 2000, NAT GENET, V25, P406, DOI 10.1038/78085
   Deng XM, 2001, J BIOL CHEM, V276, P23681, DOI 10.1074/jbc.M100279200
   Dhar D, 2020, EXP BIOL MED, V245, P96, DOI 10.1177/1535370219898141
   DORNER AJ, 1989, J BIOL CHEM, V264, P20602
   Friedman SL, 2008, GASTROENTEROLOGY, V134, P1655, DOI 10.1053/j.gastro.2008.03.003
   Fu J, 2020, BIOMED PHARMACOTHER, V131, DOI 10.1016/j.biopha.2020.110658
   Gaddam D, 2013, MOL BIOL CELL, V24, P14, DOI 10.1091/mbc.E12-06-0491
   Ghavami S, 2012, CELL DEATH DIS, V3, DOI 10.1038/cddis.2012.61
   Ghavami S, 2014, BBA-MOL CELL RES, V1843, P1259, DOI 10.1016/j.bbamcr.2014.03.006
   Groenendyk J, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0159682
   Haberzettl P, 2013, REDOX BIOL, V1, P56, DOI 10.1016/j.redox.2012.10.003
   Ham H, 2014, J BIOL CHEM, V289, P36059, DOI 10.1074/jbc.M114.612515
   Han D, 2009, CELL, V138, P562, DOI 10.1016/j.cell.2009.07.017
   He LW, 2016, PHARM BIOL, V54, P3237, DOI 10.1080/13880209.2016.1223143
   Heindryckx F, 2016, EMBO MOL MED, V8, P729, DOI 10.15252/emmm.201505925
   Hernández-Gea V, 2013, J HEPATOL, V59, P98, DOI 10.1016/j.jhep.2013.02.016
   Hetz C, 2006, SCIENCE, V312, P572, DOI 10.1126/science.1123480
   Hitomi J, 2004, NEUROSCI LETT, V357, P127, DOI 10.1016/j.neulet.2003.12.080
   Hollien J, 2006, SCIENCE, V313, P104, DOI 10.1126/science.1129631
   Hombach-Klonisch S, 2018, PHARMACOL THERAPEUT, V184, P13, DOI 10.1016/j.pharmthera.2017.10.017
   Huang Y, 2014, MOL CELL BIOCHEM, V394, P1, DOI 10.1007/s11010-014-2073-8
   Iracheta-Vellve A, 2016, J BIOL CHEM, V291, P26794, DOI 10.1074/jbc.M116.736991
   Ishikawa T, 2011, CELL DEATH DIFFER, V18, P1271, DOI 10.1038/cdd.2011.59
   Iwawaki T, 2009, P NATL ACAD SCI USA, V106, P16657, DOI 10.1073/pnas.0903775106
   Jiang Joy X, 2013, Curr Pathobiol Rep, V1, P215
   Kapoor A, 2009, CLIN LIVER DIS, V13, P581, DOI 10.1016/j.cld.2009.07.004
   Kawamura K, 2017, BMC PULM MED, V17, P23, DOI 10.1186/s12890-017-0437-z
   Kelsen SG, 2016, ANN AM THORAC SOC, V13, pS138, DOI 10.1513/AnnalsATS.201506-320KV
   Kim BJ, 2006, J BIOL CHEM, V281, P21256, DOI 10.1074/jbc.M510644200
   Kim I, 2008, NAT REV DRUG DISCOV, V7, P1013, DOI 10.1038/nrd2755
   Kim RS, 2016, SCI REP-UK, V6, DOI 10.1038/srep39342
   Kim SR, 2015, ALLERGY ASTHMA IMMUN, V7, P106, DOI 10.4168/aair.2015.7.2.106
   Kimata Y, 2007, J CELL BIOL, V179, P75, DOI 10.1083/jcb.200704166
   Koo JH, 2016, GASTROENTEROLOGY, V150, P181, DOI 10.1053/j.gastro.2015.09.039
   Kroemer G, 2010, MOL CELL, V40, P280, DOI 10.1016/j.molcel.2010.09.023
   Lebeau J, 2018, CELL REP, V22, P2827, DOI 10.1016/j.celrep.2018.02.055
   Lee K, 2002, GENE DEV, V16, P452, DOI 10.1101/gad.964702
   Li G, 2009, J CELL BIOL, V186, P783, DOI 10.1083/jcb.200904060
   Li S, 2015, INT J MOL SCI, V16, P26087, DOI 10.3390/ijms161125942
   Li XH, 2015, INFLAMM RES, V64, P1, DOI 10.1007/s00011-014-0772-y
   Li YJ, 2017, INT J MOL MED, V40, P1405, DOI 10.3892/ijmm.2017.3145
   Lin JH, 2007, SCIENCE, V318, P944, DOI 10.1126/science.1146361
   Logue SE, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05763-8
   Mahameed M, 2019, CELL DEATH DIS, V10, DOI 10.1038/s41419-019-1523-3
   Maiers JL, 2019, SEMIN LIVER DIS, V39, P235, DOI 10.1055/s-0039-1681032
   Maiers JL, 2017, HEPATOLOGY, V65, P983, DOI 10.1002/hep.28921
   Mandic A, 2003, J BIOL CHEM, V278, P9100, DOI 10.1074/jbc.M210284200
   McCullough KD, 2001, MOL CELL BIOL, V21, P1249, DOI 10.1128/MCB.21.4.1249-1259.2001
   McGrath EP, 2018, CANCERS, V10, DOI 10.3390/cancers10100344
   McMahon M, 2017, AM J PHYSIOL-CELL PH, V313, pC243, DOI 10.1152/ajpcell.00293.2016
   Mehrbod P, 2019, VIRULENCE, V10, P376, DOI 10.1080/21505594.2019.1605803
   Morishima N, 2004, J BIOL CHEM, V279, P50375, DOI 10.1074/jbc.M408493200
   Morishima N, 2002, J BIOL CHEM, V277, P34287, DOI 10.1074/jbc.M204973200
   Novo E, 2014, ARCH BIOCHEM BIOPHYS, V548, P20, DOI 10.1016/j.abb.2014.02.015
   Novoa I, 2001, J CELL BIOL, V153, P1011, DOI 10.1083/jcb.153.5.1011
   Oikawa D, 2009, EXP CELL RES, V315, P2496, DOI 10.1016/j.yexcr.2009.06.009
   Okamura K, 2000, BIOCHEM BIOPH RES CO, V279, P445, DOI 10.1006/bbrc.2000.3987
   Oyadomari S, 2004, CELL DEATH DIFFER, V11, P381, DOI 10.1038/sj.cdd.4401373
   Ozgur R, 2018, J EXP BOT, V69, P3333, DOI 10.1093/jxb/ery040
   Parola M, 2008, MOL ASPECTS MED, V29, P58, DOI 10.1016/j.mam.2007.09.002
   Preissler S, 2019, CSH PERSPECT BIOL, V11, DOI 10.1101/cshperspect.a033894
   Preissler S, 2017, NAT STRUCT MOL BIOL, V24, P23, DOI 10.1038/nsmb.3337
   Puthalakath H, 2007, CELL, V129, P1337, DOI 10.1016/j.cell.2007.04.027
   Rainbolt TK, 2014, TRENDS ENDOCRIN MET, V25, P528, DOI 10.1016/j.tem.2014.06.007
   Rizzuto R, 1998, SCIENCE, V280, P1763, DOI 10.1126/science.280.5370.1763
   Roy B, 1999, NUCLEIC ACIDS RES, V27, P1437, DOI 10.1093/nar/27.6.1437
   de Galarreta MR, 2016, BBA-MOL CELL RES, V1863, P2115, DOI 10.1016/j.bbamcr.2016.05.002
   Rutkowski DT, 2006, PLOS BIOL, V4, P2024, DOI 10.1371/journal.pbio.0040374
   Rutkowski DT, 2010, J CELL BIOL, V189, P783, DOI 10.1083/jcb.201003138
   Sakurai M, 2005, J THORAC CARDIOV SUR, V130, P640, DOI 10.1016/j.jtcvs.2005.01.007
   Salminen A, 2010, AGEING RES REV, V9, P211, DOI 10.1016/j.arr.2010.04.003
   Sano R, 2013, BBA-MOL CELL RES, V1833, P3460, DOI 10.1016/j.bbamcr.2013.06.028
   Sano R, 2012, GENE DEV, V26, P1041, DOI 10.1101/gad.184325.111
   Sato H, 2017, CELL STRUCT FUNCT, V42, P61, DOI 10.1247/csf.17002
   Schröder M, 2008, CELL MOL LIFE SCI, V65, P862, DOI 10.1007/s00018-007-7383-5
   Scorrano L, 2003, SCIENCE, V300, P135, DOI 10.1126/science.1081208
   Senft D, 2015, TRENDS BIOCHEM SCI, V40, P141, DOI 10.1016/j.tibs.2015.01.002
   Shih YC, 2018, CIRC RES, V122, P1052, DOI 10.1161/CIRCRESAHA.117.312130
   Shojaei S, 2020, VIRULENCE, V11, P805, DOI 10.1080/21505594.2020.1780088
   Shojaei S, 2020, FEBS J, V287, P1005, DOI 10.1111/febs.15069
   Shore GC, 2011, CURR OPIN CELL BIOL, V23, P143, DOI 10.1016/j.ceb.2010.11.003
   Shutt TE, 2013, BBA-MOL CELL RES, V1833, P417, DOI 10.1016/j.bbamcr.2012.05.024
   Srinivasan V, 2020, FRONT CELL NEUROSCI, V14, DOI 10.3389/fncel.2020.554548
   Sundaram A, 2018, MOL BIOL CELL, V29, P1376, DOI 10.1091/mbc.E17-10-0594
   Sundaram A, 2017, ELIFE, V6, DOI 10.7554/eLife.27187
   Sureda A, 2020, EUR J PHARMACOL, V882, DOI 10.1016/j.ejphar.2020.173288
   Szegezdi E, 2006, EMBO REP, V7, P880, DOI 10.1038/sj.embor.7400779
   Tiao Mao-Meng, 2009, Chang Gung Med J, V32, P346
   Tinhofer I, 2002, FASEB J, V16, P1295, DOI 10.1096/fj.02-0020fje
   Toosi AEK, 2015, ROM J INTERN MED, V53, P304, DOI 10.1515/rjim-2015-0039
   Tsubouchi K, 2017, AUTOPHAGY, V13, P1420, DOI 10.1080/15548627.2017.1328348
   Tsuru A, 2013, P NATL ACAD SCI USA, V110, P2864, DOI 10.1073/pnas.1212484110
   Upton JP, 2012, SCIENCE, V338, P818, DOI 10.1126/science.1226191
   Van de Craen M, 1997, FEBS LETT, V403, P61, DOI 10.1016/S0014-5793(97)00026-4
   Varadarajan S, 2012, CELL DEATH DIFFER, V19, P1896, DOI 10.1038/cdd.2012.108
   Veyron S, 2018, PATHOG DIS, V76, DOI 10.1093/femspd/fty012
   Wai T, 2016, TRENDS ENDOCRIN MET, V27, P105, DOI 10.1016/j.tem.2015.12.001
   Walter P, 2011, SCIENCE, V334, P1081, DOI 10.1126/science.1209038
   Wang C, 2016, SCI REP-UK, V6, DOI 10.1038/srep34330
   Wang M, 2016, NATURE, V529, P326, DOI 10.1038/nature17041
   Wang M, 2009, ANTIOXID REDOX SIGN, V11, P2307, DOI [10.1089/ars.2009.2485, 10.1089/ARS.2009.2485]
   Wang XZ, 1996, SCIENCE, V272, P1347, DOI 10.1126/science.272.5266.1347
   Wei W, 2018, PARASITE VECTOR, V11, DOI 10.1186/s13071-018-2835-3
   Wei YJ, 2008, MOL CELL, V30, P678, DOI 10.1016/j.molcel.2008.06.001
   Wek RC, 2007, ANTIOXID REDOX SIGN, V9, P2357, DOI 10.1089/ars.2007.1764
   Yanagitani K, 2009, MOL CELL, V34, P191, DOI 10.1016/j.molcel.2009.02.033
   Yeganeh B, 2015, WORLD J GASTROENTERO, V21, P13225, DOI 10.3748/wjg.v21.i47.13225
   Yeganeh B, 2013, IRAN J ALLERGY ASTHM, V12, P1, DOI 012.01/ijaai.117
   Yie Q, 2002, HEPATOLOGY, V36, P592, DOI 10.1053/jhep.2002.35441
   Yoshida H, 2001, CELL, V107, P881, DOI 10.1016/S0092-8674(01)00611-0
   Zhao G, 2014, GUT, V63, P1159, DOI 10.1136/gutjnl-2013-305507
NR 139
TC 1
Z9 1
U1 1
U2 15
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-2037
EI 1875-5550
J9 CURR PROTEIN PEPT SC
JI Curr. Protein Pept. Sci.
PY 2024
VL 25
IS 1
BP 59
EP 70
DI 10.2174/1389203724666230822085951
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA HU5Q6
UT WOS:001162037200001
PM 37608655
DA 2025-06-11
ER

PT J
AU Qian, X
   Li, XJ
   Tan, L
   Lee, JH
   Xia, Y
   Cai, QS
   Zheng, YH
   Wang, HX
   Lorenzi, PL
   Lu, ZM
AF Qian, Xu
   Li, Xinjian
   Tan, Lin
   Lee, Jong-Ho
   Xia, Yan
   Cai, Qingsong
   Zheng, Yanhua
   Wang, Hongxia
   Lorenzi, Philip L.
   Lu, Zhimin
TI Conversion of PRPS Hexamer to Monomer by AMPK-Mediated Phosphorylation
   Inhibits Nucleotide Synthesis in Response to Energy Stress
SO CANCER DISCOVERY
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE; NOVO PYRIMIDINE SYNTHESIS; ENZYMATIC
   SYNTHESIS; METABOLIC SYNDROME; BETA-CATENIN; CANCER; HOMEOSTASIS;
   SYNTHETASE; APOPTOSIS; GROWTH
AB Tumors override energy stress to grow. However, how nucleotide synthesis is regulated under energy stress is unclear. We demonstrate here that glucose deprivation or hypoxia results in the AMPK-mediated phosphorylation of phosphoribosyl pyrophosphate synthetase 1 (PRPS1) S180 and PRPS2 S183, leading to conversion of PRPS hexamers to monomers and thereby inhibiting PRPS1/2 activity, nucleotide synthesis, and nicotinamide adenine dinucleotide (NAD) production. Knock-in of nonphosphorylatable PRPS1/2 mutants, which have uninhibited activity, in brain tumor cells under energy stress exhausts cellular ATP and NADPH and increases reactive oxygen species levels, thereby promoting cell apoptosis. The expression of those mutants inhibits brain tumor formation and enhances the inhibitory effect of the glycolysis inhibitor 2-deoxy-D-glucose on tumor growth. Our findings highlight the significance of recalibrating tumor cell metabolism by fine-tuning nucleotide and NAD synthesis in tumor growth. (c) 2017 AACR.
C1 [Qian, Xu; Li, Xinjian; Lee, Jong-Ho; Xia, Yan; Cai, Qingsong; Zheng, Yanhua; Lu, Zhimin] Univ Texas MD Anderson Canc Ctr, Brain Tumor Ctr, Houston, TX 77030 USA.
   [Qian, Xu; Li, Xinjian; Lee, Jong-Ho; Xia, Yan; Cai, Qingsong; Zheng, Yanhua; Lu, Zhimin] Univ Texas MD Anderson Canc Ctr, Dept Neurooncol, Houston, TX 77030 USA.
   [Tan, Lin; Lorenzi, Philip L.] Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA.
   [Tan, Lin; Lorenzi, Philip L.] Univ Texas MD Anderson Canc Ctr, Prote & Metab Core Facil, Houston, TX 77030 USA.
   [Wang, Hongxia] Shanghai Jiao Tong Univ, Inst Cell Metab & Dis, Shanghai Gen Hosp, Shanghai Key Lab Pancreat Canc,Sch Med, Shanghai, Peoples R China.
   [Lu, Zhimin] Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA.
   [Lu, Zhimin] Univ Texas MD Anderson Canc Ctr, Canc Biol Program, UT Hlth Grad Sch Biomed Sci, Houston, TX 77030 USA.
C3 University of Texas System; UTMD Anderson Cancer Center; University of
   Texas System; UTMD Anderson Cancer Center; University of Texas System;
   UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson
   Cancer Center; Shanghai Jiao Tong University; University of Texas
   System; UTMD Anderson Cancer Center; University of Texas System; UTMD
   Anderson Cancer Center
RP Lu, ZM (corresponding author), Univ Texas MD Anderson Canc Ctr, 1515 Holcombe Blvd,Unit 1002, Houston, TX 77030 USA.
EM zhiminlu@mdanderson.org
RI Lu, Zhimin/LZF-0860-2025; Wang, Hongxia/AAU-5674-2021
FU National Institute of Neurological Disorders and Stroke [R01 NS089754];
   National Cancer Institute [2R01 CA109035, R01 CA169603]; Brain Cancer
   SPORE [2P50 CA127001]; MD Anderson's Cancer Center Support Grant
   [CA016672]; National Natural Science Foundation of China (NSFC)
   [816228011, 81572499, 81572700]
FX This work was supported by National Institute of Neurological Disorders
   and Stroke grant R01 NS089754 (Z. Lu), National Cancer Institute grants
   2R01 CA109035 (Z. Lu) and R01 CA169603 (Z. Lu), 2P50 CA127001 (Brain
   Cancer SPORE), MD Anderson's Cancer Center Support Grant CA016672, and
   the National Natural Science Foundation of China (NSFC) 816228011 (H.
   Wang), 81572499, and 81572700. Z. Lu is a Ruby E. Rutherford
   Distinguished Professor.
CR Ben-Sahra I, 2016, SCIENCE, V351, P728, DOI 10.1126/science.aad0489
   Ben-Sahra I, 2013, SCIENCE, V339, P1323, DOI 10.1126/science.1228792
   Browne GJ, 2004, J BIOL CHEM, V279, P12220, DOI 10.1074/jbc.M309773200
   Bungard D, 2010, SCIENCE, V329, P1201, DOI 10.1126/science.1191241
   Cairns RA, 2011, NAT REV CANCER, V11, P85, DOI 10.1038/nrc2981
   Cantó C, 2015, CELL METAB, V22, P31, DOI 10.1016/j.cmet.2015.05.023
   Chen PZ, 2015, INT J COMPUT GAMES T, V2015, DOI 10.1155/2015/695874
   Crute BE, 1998, J BIOL CHEM, V273, P35347, DOI 10.1074/jbc.273.52.35347
   Cunningham JT, 2014, CELL, V157, P1088, DOI 10.1016/j.cell.2014.03.052
   Eguchi Y, 1997, CANCER RES, V57, P1835
   Fang DX, 2007, J BIOL CHEM, V282, P11221, DOI 10.1074/jbc.M611871200
   Gwinn DM, 2008, MOL CELL, V30, P214, DOI 10.1016/j.molcel.2008.03.003
   Hardie DG, 2016, TRENDS CELL BIOL, V26, P190, DOI 10.1016/j.tcb.2015.10.013
   Hardie DG, 2012, NAT REV MOL CELL BIO, V13, P251, DOI 10.1038/nrm3311
   Heiden MGV, 2009, SCIENCE, V324, P1029, DOI 10.1126/science.1160809
   Horman S, 2008, J BIOL CHEM, V283, P18505, DOI 10.1074/jbc.M802053200
   HOVEJENSEN B, 1988, J BACTERIOL, V170, P1148, DOI 10.1128/jb.170.3.1148-1152.1988
   Ingram-Smith C, 2006, BIOCHEMISTRY-US, V45, P11482, DOI 10.1021/bi061023e
   Ishimoto T, 2012, P NATL ACAD SCI USA, V109, P4320, DOI 10.1073/pnas.1119908109
   Jeon SM, 2012, NATURE, V485, P661, DOI 10.1038/nature11066
   Johanns M, 2017, CELL SIGNAL, V36, P212, DOI 10.1016/j.cellsig.2017.05.010
   Jordan A, 1998, ANNU REV BIOCHEM, V67, P71, DOI 10.1146/annurev.biochem.67.1.71
   KHORANA HG, 1958, J BIOL CHEM, V230, P941
   Kleinstiver BP, 2016, NATURE, V529, P490, DOI 10.1038/nature16526
   Koppenol WH, 2011, NAT REV CANCER, V11, P325, DOI 10.1038/nrc3038
   KORNBERG A, 1955, J BIOL CHEM, V215, P389
   Lane AN, 2015, NUCLEIC ACIDS RES, V43, P2466, DOI 10.1093/nar/gkv047
   Leist M, 1997, J EXP MED, V185, P1481, DOI 10.1084/jem.185.8.1481
   Li BS, 2015, NAT MED, V21, P563, DOI 10.1038/nm.3840
   Li S, 2007, BIOCHEM J, V401, P39, DOI 10.1042/BJ20061066
   Li XJ, 2016, CELL CYCLE, V15, P2689, DOI 10.1080/15384101.2016.1204861
   Li XJ, 2016, NAT CELL BIOL, V18, P561, DOI 10.1038/ncb3338
   Li XJ, 2016, MOL CELL, V61, P705, DOI 10.1016/j.molcel.2016.02.009
   Lin RT, 2015, NAT CELL BIOL, V17, P1484, DOI 10.1038/ncb3255
   Liu LD, 2012, NATURE, V483, P608, DOI 10.1038/nature10927
   Lu ZM, 2009, ANNU REV BIOCHEM, V78, P435, DOI 10.1146/annurev.biochem.013008.092711
   Lu ZM, 1998, MOL CELL BIOL, V18, P839, DOI 10.1128/MCB.18.2.839
   Lyssiotis CA, 2014, CELL, V159, P1492, DOI 10.1016/j.cell.2014.12.009
   Lyssiotis CA, 2013, NATURE, V502, P181, DOI 10.1038/502181a
   Mannava S, 2008, CELL CYCLE, V7, P2392, DOI 10.4161/cc.6390
   McMahon Steven B, 2008, Cell Cycle, V7, P2275
   NOSAL JM, 1993, J BIOL CHEM, V268, P10168
   Pettersen EF, 2004, J COMPUT CHEM, V25, P1605, DOI 10.1002/jcc.20084
   Robitaille AM, 2013, SCIENCE, V339, P1320, DOI 10.1126/science.1228771
   Shackelford DB, 2009, NAT REV CANCER, V9, P563, DOI 10.1038/nrc2676
   Tanaka H, 2000, NATURE, V404, P42, DOI 10.1038/35003506
   WAGNER TC, 1994, ANAL BIOCHEM, V222, P417, DOI 10.1006/abio.1994.1511
   Wang YL, 2000, TRENDS BIOCHEM SCI, V25, P300, DOI 10.1016/S0968-0004(00)01561-9
   Xia Y, 2007, MOL CELL, V25, P219, DOI 10.1016/j.molcel.2007.01.005
   Yang M, 2016, NAT REV CANCER, V16, P650, DOI 10.1038/nrc.2016.81
   Yang WW, 2013, CELL CYCLE, V12, P3154, DOI 10.4161/cc.26182
   Yang WW, 2011, NATURE, V480, P118, DOI 10.1038/nature10598
NR 52
TC 63
Z9 69
U1 3
U2 27
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 2159-8274
EI 2159-8290
J9 CANCER DISCOV
JI Cancer Discov.
PD JAN
PY 2018
VL 8
IS 1
BP 94
EP 107
DI 10.1158/2159-8290.CD-17-0712
PG 14
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA FS1PR
UT WOS:000419549800026
PM 29074724
OA Green Accepted, Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Tomaipitinca, L
   Mandatori, S
   Mancinelli, R
   Giulitti, F
   Petrungaro, S
   Moresi, V
   Facchiano, A
   Ziparo, E
   Gaudio, E
   Giampietri, C
AF Tomaipitinca, Luana
   Mandatori, Sara
   Mancinelli, Romina
   Giulitti, Federico
   Petrungaro, Simonetta
   Moresi, Viviana
   Facchiano, Antonio
   Ziparo, Elio
   Gaudio, Eugenio
   Giampietri, Claudia
TI The Role of Autophagy in Liver Epithelial Cells and Its Impact on
   Systemic Homeostasis
SO NUTRIENTS
LA English
DT Review
DE autophagy; liver; lipid droplets; metabolism; oxidative stress; cancer
ID OXIDATIVE STRESS; ENDOTHELIAL-CELL; ER STRESS; CHOLANGIOCYTE AUTOPHAGY;
   HEPATIC AUTOPHAGY; SHEAR-STRESS; MELANOMA; DISEASE; PROTEIN; OBESITY
AB Autophagy plays a role in several physiological and pathological processes as it controls the turnover rate of cellular components and influences cellular homeostasis. The liver plays a central role in controlling organisms' metabolism, regulating glucose storage, plasma proteins and bile synthesis and the removal of toxic substances. Liver functions are particularly sensitive to autophagy modulation. In this review we summarize studies investigating how autophagy influences the hepatic metabolism, focusing on fat accumulation and lipids turnover. We also describe how autophagy affects bile production and the scavenger function within the complex homeostasis of the liver. We underline the role of hepatic autophagy in counteracting the metabolic syndrome and the associated cardiovascular risk. Finally, we highlight recent reports demonstrating how the autophagy occurring within the liver may affect skeletal muscle homeostasis as well as different extrahepatic solid tumors, such as melanoma.
C1 [Tomaipitinca, Luana; Mandatori, Sara; Mancinelli, Romina; Giulitti, Federico; Petrungaro, Simonetta; Moresi, Viviana; Ziparo, Elio; Gaudio, Eugenio; Giampietri, Claudia] Sapienza Univ Rome, Dept Anat Histol Forens Med & Orthoped Sci, I-00161 Rome, Italy.
   [Facchiano, Antonio] IRCCS, IDI, Mol Oncol Lab, I-00167 Rome, Italy.
C3 Sapienza University Rome; IRCCS Istituto Dermopatico dell'Immacolata
   (IDI)
RP Giampietri, C (corresponding author), Sapienza Univ Rome, Dept Anat Histol Forens Med & Orthoped Sci, I-00161 Rome, Italy.
EM luana.tomaipitinca@uniroma1.it; sara.mandatori@uniroma1.it;
   romina.mancinelli@uniroma1.it; federico.giulitti@uniroma1.it;
   simonetta.petrungaro@uniroma1.it; viviana.moresi@uniroma1.it;
   a.facchiano@idi.it; elio.ziparo@uniroma1.it; eugenio.gaudio@uniroma1.it;
   claudia.giampietri@uniroma1.it
RI Facchiano, Antonio/J-4744-2012; Tomaipitinca, Luana/AAC-2165-2019;
   Moresi, Viviana/N-7977-2013; Mancinelli, Romina/Y-4540-2018; Facchiano,
   Antonio/K-5984-2016
OI Giampietri, Claudia/0000-0002-5025-5365; Moresi,
   viviana/0000-0003-1912-0339; Mancinelli, Romina/0000-0003-2040-0581;
   Tomaipitinca, Luana/0000-0002-3862-7787; Mandatori,
   Sara/0000-0002-4666-2021; Facchiano, Antonio/0000-0002-4243-2392;
   petrungaro, simonetta/0000-0001-7283-4977
FU Ricerca Scientifica Sapienza 2015 grant; Ricerca Scientifica Sapienza
   2018 grant; "Cooperation with developing countries Sapienza 2017"
FX This research was funded by "Ricerca Scientifica Sapienza 2015 and 2018"
   grants to E.Z. and C.G. and by "Cooperation with developing countries
   Sapienza 2017" grant to C.G.
CR Adams Paul, 2008, Gastroenterol Hepatol (N Y), V4, P333
   Allaire M, 2019, J HEPATOL, V70, P985, DOI 10.1016/j.jhep.2019.01.026
   Bai YS, 2019, BIOCHEM BIOPH RES CO, V508, P997, DOI 10.1016/j.bbrc.2018.12.039
   Baldi A, 2005, CLIN CANCER RES, V11, P3175, DOI 10.1158/1078-0432.CCR-04-0631
   Beau I, 2008, TRENDS CELL BIOL, V18, P311, DOI 10.1016/j.tcb.2008.05.001
   Bogdan AR, 2016, TRENDS BIOCHEM SCI, V41, P274, DOI 10.1016/j.tibs.2015.11.012
   Boteon YL, 2017, WORLD J GASTROENTERO, V23, P8443, DOI 10.3748/wjg.v23.i48.8443
   Boutouja F, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18122541
   BOUWENS L, 1992, ENZYME, V46, P155, DOI 10.1159/000468782
   Brasaemle DL, 2007, J LIPID RES, V48, P2547, DOI 10.1194/jlr.R700014-JLR200
   Brasaemle DL, 2012, J BIOL CHEM, V287, P2273, DOI 10.1074/jbc.R111.309088
   Castorina Sergio, 2008, Italian Journal of Anatomy and Embryology, V113, P199
   Chen N, 2011, CANCER BIOL THER, V11, P157, DOI 10.4161/cbt.11.2.14622
   Cheng YJ, 2015, CELL PHYSIOL BIOCHEM, V36, P1163, DOI 10.1159/000430287
   CHIANG HL, 1989, SCIENCE, V246, P382, DOI 10.1126/science.2799391
   Cingolani F, 2016, TRENDS ENDOCRIN MET, V27, P696, DOI 10.1016/j.tem.2016.06.003
   Clement E, 2017, PIGM CELL MELANOMA R, V30, P294, DOI 10.1111/pcmr.12584
   Conti S, 2016, CELL SIGNAL, V28, P1262, DOI 10.1016/j.cellsig.2016.06.003
   Cuervo AM, 2008, TRENDS GENET, V24, P604, DOI 10.1016/j.tig.2008.10.002
   D'Arcangelo D, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/1471682
   DETER RL, 1967, J CELL BIOL, V35, pC11, DOI 10.1083/jcb.35.2.C11
   Di Leo L, 2019, ONCOGENE, V38, P1860, DOI 10.1038/s41388-018-0545-0
   Ding SB, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0183541
   Ding WX, 2010, GASTROENTEROLOGY, V139, P1740, DOI 10.1053/j.gastro.2010.07.041
   Dixon LJ, 2013, COMPR PHYSIOL, V3, P785, DOI 10.1002/cphy.c120026
   Dobbins M, 2013, ISRN Prev Med, V2013, P680536, DOI 10.5402/2013/680536
   Dooley HC, 2014, MOL CELL, V55, P238, DOI 10.1016/j.molcel.2014.05.021
   Elmansi AM, 2017, ANN HEPATOL, V16, P607, DOI 10.5604/01.3001.0010.0307
   Ezaki J, 2011, AUTOPHAGY, V7, P727, DOI 10.4161/auto.7.7.15371
   Filomeni G, 2015, CELL DEATH DIFFER, V22, P377, DOI 10.1038/cdd.2014.150
   Fraczek J, 2013, ARCH TOXICOL, V87, P577, DOI 10.1007/s00204-012-0983-3
   Gaudio E, 1997, DIGEST DIS SCI, V42, P167, DOI 10.1023/A:1018813911469
   Gera S, 2017, WORLD J HEPATOL, V9, P300, DOI 10.4254/wjh.v9.i6.300
   Giampietri C, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18061271
   González-Rodríguez A, 2014, CELL DEATH DIS, V5, DOI 10.1038/cddis.2014.162
   Goodall EF, 2008, J NEUROL, V255, P1652, DOI 10.1007/s00415-008-0945-0
   Grumati P, 2018, J CELL SCI, V131, DOI 10.1242/jcs.217364
   Guo FX, 2014, ANN BIOMED ENG, V42, P1978, DOI 10.1007/s10439-014-1033-5
   Han YY, 2014, AM J PHYSIOL-GASTR L, V307, pG894, DOI 10.1152/ajpgi.00288.2014
   Hase K, 2015, NUCLEIC ACIDS RES, V43, P6439, DOI 10.1093/nar/gkv579
   Hayes AJ, 2018, LANCET ONCOL, V19, P269, DOI 10.1016/S1470-2045(18)30077-9
   Hildebrand D, 2018, FRONT CELL INFECT MI, V8, DOI 10.3389/fcimb.2018.00241
   Hosokawa N, 2009, MOL BIOL CELL, V20, P1981, DOI 10.1091/mbc.E08-12-1248
   Hou W, 2016, AUTOPHAGY, V12, P1425, DOI 10.1080/15548627.2016.1187366
   Jiang F, 2016, CLIN EXP PHARMACOL P, V43, P1021, DOI 10.1111/1440-1681.12649
   Jiao M, 2014, CELL DEATH DIS, V5, DOI 10.1038/cddis.2014.361
   Jin Y, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19113445
   Kaushik S, 2010, DIABETES OBES METAB, V12, P4, DOI 10.1111/j.1463-1326.2010.01263.x
   Kaushik S, 2018, NAT REV MOL CELL BIO, V19, P365, DOI 10.1038/s41580-018-0001-6
   Key TJ, 2007, EUR J CLIN NUTR, V61, pS112, DOI 10.1038/sj.ejcn.1602941
   Khan SA, 2015, DIABETES, V64, P418, DOI 10.2337/db14-0325
   Kharbanda KK, 1995, BBA-GEN SUBJECTS, V1245, P421, DOI 10.1016/0304-4165(95)00121-2
   Kim HM, 2018, NUTRITION, V55-56, P63, DOI 10.1016/j.nut.2018.03.010
   Klionsky DJ, 2016, AUTOPHAGY, V12, P1, DOI 10.1080/15548627.2015.1100356
   Kmiec Z, 2001, ADV ANAT EMBRYOL CEL, V161, P1
   Kon M, 2010, FEBS LETT, V584, P1399, DOI 10.1016/j.febslet.2009.12.025
   Korenblat KM, 2008, GASTROENTEROLOGY, V134, P1369, DOI 10.1053/j.gastro.2008.01.075
   Kuzu OF, 2016, CANCER RES, V76, P2063, DOI 10.1158/0008-5472.CAN-15-2613
   Kuzu OF, 2014, MOL CANCER THER, V13, P1690, DOI 10.1158/1535-7163.MCT-13-0868
   Kwon DH, 2018, MOL CELLS, V41, P27, DOI 10.14348/molcells.2018.2274
   Lee IH, 2008, P NATL ACAD SCI USA, V105, P3374, DOI 10.1073/pnas.0712145105
   Lee JM, 2014, NATURE, V516, P112, DOI 10.1038/nature13961
   Lee YK, 2016, BMB REP, V49, P424, DOI 10.5483/BMBRep.2016.49.8.081
   Lim S, 2019, OBES REV, V20, P599, DOI 10.1111/obr.12820
   Liu XR, 2018, MOL CANCER, V17, DOI 10.1186/s12943-018-0838-5
   Luo XY, 2018, CELL DEATH DIS, V9, DOI 10.1038/s41419-018-0567-0
   Luo Y, 2016, CHEM-BIOL INTERACT, V255, P55, DOI 10.1016/j.cbi.2016.03.007
   Mancias JD, 2014, NATURE, V509, P105, DOI 10.1038/nature13148
   Mancinelli R, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/4629495
   Marini ES, 2015, CELL DEATH DIFFER, V22, P1131, DOI 10.1038/cdd.2014.197
   Masouminia M, 2018, J SEX MED, V15, P1678, DOI 10.1016/j.jsxm.2018.09.019
   Masyuk AI, 2018, HEPATOLOGY, V67, P1088, DOI 10.1002/hep.29577
   McQuade JL, 2018, LANCET ONCOL, V19, P310, DOI 10.1016/S1470-2045(18)30078-0
   Mizushima N, 2007, GENE DEV, V21, P2861, DOI 10.1101/gad.1599207
   Mizushima N, 2018, NAT CELL BIOL, V20, P521, DOI 10.1038/s41556-018-0092-5
   Montagna C, 2016, FEBS J, V283, P3857, DOI 10.1111/febs.13736
   Nadjar Y, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0045034
   Nakamura S, 2017, J CELL SCI, V130, P1209, DOI 10.1242/jcs.196352
   Nakatani Kazuki, 2004, Medical Electron Microscopy, V37, P29, DOI 10.1007/s00795-003-0229-9
   Ohsumi Y, 2001, NAT REV MOL CELL BIO, V2, P211, DOI 10.1038/35056522
   Oku M, 2018, BIOESSAYS, V40, DOI 10.1002/bies.201800008
   Paquette M, 2018, CANCERS, V10, DOI 10.3390/cancers10010018
   Petibone DM, 2017, J APPL TOXICOL, V37, P23, DOI 10.1002/jat.3393
   Pfluger PT, 2008, P NATL ACAD SCI USA, V105, P9793, DOI 10.1073/pnas.0802917105
   Poirot M, 2018, BIOCHEM PHARMACOL, V153, P75, DOI 10.1016/j.bcp.2018.01.046
   Ren LF, 2019, BIOL TRACE ELEM RES, V191, P443, DOI 10.1007/s12011-019-1641-x
   Rout AK, 2014, J BIOL CHEM, V289, P35111, DOI 10.1074/jbc.M114.609446
   Roux PP, 2018, MOL CELL BIOL, V38, DOI 10.1128/MCB.00070-18
   Ruart M, 2019, J HEPATOL, V70, P458, DOI 10.1016/j.jhep.2018.10.015
   Salemi S, 2012, CELL RES, V22, P432, DOI 10.1038/cr.2011.200
   Sanchez-Roman I, 2013, EXP GERONTOL, V48, P1030, DOI 10.1016/j.exger.2013.02.021
   Sasaki M, 2017, DIGEST DIS, V35, P210, DOI 10.1159/000450913
   Sato K, 2018, BBA-MOL BASIS DIS, V1864, P1262, DOI 10.1016/j.bbadis.2017.06.017
   Schneider JL, 2014, CELL METAB, V20, P417, DOI 10.1016/j.cmet.2014.06.009
   Schroeder B, 2015, HEPATOLOGY, V61, P1896, DOI 10.1002/hep.27667
   Schulze RJ, 2017, HEPATOL COMMUN, V1, P140, DOI 10.1002/hep4.1021
   Sedlackova L, 2019, BBA-MOL CELL RES, V1866, P575, DOI 10.1016/j.bbamcr.2018.12.012
   Sekiya M, 2008, BIOCHEM BIOPH RES CO, V375, P602, DOI 10.1016/j.bbrc.2008.08.068
   Sevim DG, 2016, MELANOMA RES, V26, P164, DOI 10.1097/CMR.0000000000000226
   Sharma L, 2018, FOOD CHEM TOXICOL, V121, P283, DOI 10.1016/j.fct.2018.09.011
   Sharp KPH, 2018, JGH OPEN, V2, P59, DOI 10.1002/jgh3.12040
   Singh R., 2012, INT J CELL BIOL
   Singh R, 2009, NATURE, V458, P1131, DOI 10.1038/nature07976
   Sorensen KK, 2015, COMPR PHYSIOL, V5, P1751, DOI 10.1002/cphy.c140078
   Stefanadi EC, 2018, DIABETOL METAB SYNDR, V10, DOI 10.1186/s13098-018-0311-z
   Takiguchi M, 1998, INT J EXP PATHOL, V79, P369, DOI 10.1046/j.1365-2613.1998.00082.x
   Tang MZ, 2018, J CELL PHYSIOL, V233, P9179, DOI 10.1002/jcp.26954
   Tanimizu N, 2016, HEPATOL RES, V46, P964, DOI 10.1111/hepr.12654
   Thomes PG, 2017, J NUTR BIOCHEM, V43, P141, DOI 10.1016/j.jnutbio.2017.02.008
   Thomes PG, 2015, ALCOHOL CLIN EXP RES, V39, P2354, DOI 10.1111/acer.12904
   Todde V, 2009, BBA-MOL BASIS DIS, V1792, P3, DOI 10.1016/j.bbadis.2008.10.016
   Tsai TH, 2017, AUTOPHAGY, V13, P1130, DOI 10.1080/15548627.2017.1319544
   TSUKADA M, 1993, FEBS LETT, V333, P169, DOI 10.1016/0014-5793(93)80398-E
   Vegliante R, 2018, CELL DEATH DIS, V9, DOI 10.1038/s41419-018-0345-z
   Wang X, 2017, MOLECULES, V22, DOI 10.3390/molecules22081315
   Wang YF, 2018, BBA-MOL CELL BIOL L, V1863, P726, DOI 10.1016/j.bbalip.2018.04.005
   Weiskirchen R, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8010016
   Willett W, 2019, LANCET, V393, P447, DOI 10.1016/S0140-6736(18)31788-4
   Yan SM, 2017, AMINO ACIDS, V49, P1965, DOI 10.1007/s00726-017-2429-y
   Yang L, 2010, CELL METAB, V11, P467, DOI 10.1016/j.cmet.2010.04.005
   Yang Q, 2016, ANN BIOMED ENG, V44, P2218, DOI 10.1007/s10439-015-1491-4
   Zechner R, 2009, J LIPID RES, V50, P3, DOI 10.1194/jlr.R800031-JLR200
   Zeng JX, 2016, CELL CYCLE, V15, P1602, DOI 10.1080/15384101.2016.1181234
   Zhang EX, 2016, SCI REP-UK, V6, DOI 10.1038/srep38138
   Zhang ZL, 2018, BIOMED PHARMACOTHER, V97, P339, DOI 10.1016/j.biopha.2017.07.168
   Zhu XF, 2017, INT J ONCOL, V50, P835, DOI 10.3892/ijo.2017.3873
   Zhuang J, 2019, J NUTR BIOCHEM, V65, P35, DOI 10.1016/j.jnutbio.2018.10.015
   Zientara-Rytter K, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8010040
   Zong YW, 2009, DEVELOPMENT, V136, P1727, DOI 10.1242/dev.029140
NR 129
TC 21
Z9 22
U1 2
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2019
VL 11
IS 4
AR 827
DI 10.3390/nu11040827
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HX9SX
UT WOS:000467749800120
PM 30979078
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Fachin, A
   Silva, RKS
   Noschang, CG
   Pettenuzzo, L
   Bertinetti, L
   Billodre, MN
   Peres, W
   Busnello, F
   Dalmaz, C
AF Fachin, Andrelisa
   S. Silva, Rachel Krolow
   Noschang, Cristie G.
   Pettenuzzo, Leticia
   Bertinetti, Liane
   Billodre, Mauro Nor
   Peres, William
   Busnello, Fernanda
   Dalmaz, Carla
TI Stress effects on rats chronically receiving a highly palatable diet are
   sex-specific
SO APPETITE
LA English
DT Article
DE Chronic stress; Palatable diet; Chocolate; Sex; Abdominal fat; Insulin;
   Plasma lipids
ID CHRONIC RESTRAINT STRESS; FEEDING-BEHAVIOR; METABOLIC SYNDROME;
   PLASMA-GLUCOSE; LEPTIN; FEMALE; GLUCOCORTICOIDS; OBESITY;
   NEUROENDOCRINE; CHOLESTEROL
AB The stress response is known to lead to behavioral and metabolic changes. Exposure to chronic stress can promote the development of physiological and behavioral dysfunctions, including alterations in feeding behavior. The aim of this study was to verify whether chronic restraint stress alters the consumption of a highly palatable, highly caloric diet (chocolate), chronically offered to the animals. Male rats ate more chocolate than females. and they also exhibited a higher weight gain, abdominal fat deposition, and higher plasma levels of total cholesterol, LDL-cholesterol and glucose. The stress exposure decreased body weight, increased adrenal weight and decreased plasma insulin levels. Overall, female rats had lower plasma insulin levels and chocolate consumption prevented the increased adrenal :gland weight after exposure to chronic stress, suggesting a reduction of stress effects induced by palatable food consumption. Taken together, these results suggest a peculiar metabolic pattern, related to energy store and expenditure, in stressed animals receiving a palatable diet. Since these effects were sex-specific, we may also propose that females and males subjected to restraint stress and chocolate consumption are differentially affected. (c) 2008 Elsevier Ltd. All rights reserved.
C1 [Fachin, Andrelisa; S. Silva, Rachel Krolow; Noschang, Cristie G.; Pettenuzzo, Leticia; Bertinetti, Liane; Billodre, Mauro Nor; Peres, William; Dalmaz, Carla] Univ Fed Rio Grande do Sul, Dept Bioquim, Inst Ciencias Basicas Saude, BR-90035003 Porto Alegre, RS, Brazil.
   [Fachin, Andrelisa; Busnello, Fernanda] FFFCMPA, Nutr, Porto Alegre, RS, Brazil.
   [Peres, William] Univ Catolica Pelotas, Dept Biochem, Pelotas, RS, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Universidade Federal de
   Pelotas; Universidade Catolica de Pelotas
RP Dalmaz, C (corresponding author), Univ Fed Rio Grande do Sul, Dept Bioquim, Inst Ciencias Basicas Saude, Ramiro Barcelos 2600 Anexo Lab 11, BR-90035003 Porto Alegre, RS, Brazil.
EM carladalmaz@yahoo.com.br
RI dalmaz, carla/M-2069-2014; Peres, William/ABG-7413-2021; Busnello,
   Fernanda/AEX-2991-2022; bertinetti, luca/M-8242-2016; Pettenuzzo,
   Leticia/N-9293-2017
OI Michielin Busnello, Fernanda/0000-0001-9091-142X; bertinetti,
   luca/0000-0002-4666-9610; Pettenuzzo, Leticia/0000-0001-6740-6177;
   Dalmaz, Carla/0000-0001-5397-2792
FU National Research Council of Brazil (CNPq); FAPERGS-PRONEX; FINEP/Rede
   IBN [01.06.0842-00]
FX National Research Council of Brazil (CNPq), FAPERGS-PRONEX and
   FINEP/Rede IBN 01.06.0842-00.
CR Adam TC, 2007, PHYSIOL BEHAV, V91, P449, DOI 10.1016/j.physbeh.2007.04.011
   APPLE JK, 1995, J ANIM SCI, V73, P2295
   Attia DM, 2003, AM J PHYSIOL-RENAL, V284, pF718, DOI 10.1152/ajprenal.00009.2002
   Baranowska B, 2008, NEUROENDOCRINOL LETT, V29, P37
   Benetti CDS, 2007, PEDIATR RES, V62, P405, DOI 10.1203/PDR.0b013e31813cbe8b
   Benoit SC, 2004, RECENT PROG HORM RES, V59, P267, DOI 10.1210/rp.59.1.267
   Berthoud HR, 2008, ANNU REV PSYCHOL, V59, P55, DOI 10.1146/annurev.psych.59.103006.093551
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   Bodnar RJ, 2006, PEPTIDES, V27, P3391, DOI 10.1016/j.peptides.2006.07.011
   Boswell KJ, 2006, PHARMACOL BIOCHEM BE, V84, P84, DOI 10.1016/j.pbb.2006.04.010
   Boullu-Ciocca S, 2005, DIABETES, V54, P197, DOI 10.2337/diabetes.54.1.197
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   CHROUSOS GP, 1992, JAMA-J AM MED ASSOC, V267, P1244, DOI 10.1001/jama.267.9.1244
   Coy RT, 2006, NUTR NEUROSCI, V9, P131, DOI 10.1080/10284150600895881
   Dallman MF, 2005, BRAIN BEHAV IMMUN, V19, P275, DOI 10.1016/j.bbi.2004.11.004
   Dallman MF, 2003, P NATL ACAD SCI USA, V100, P11696, DOI 10.1073/pnas.1934666100
   Duclos M, 2005, OBES RES, V13, P1157, DOI 10.1038/oby.2005.137
   Ely DR, 1997, PHYSIOL BEHAV, V61, P395, DOI 10.1016/S0031-9384(96)00450-7
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Gamaro GD, 2003, PHARMACOL BIOCHEM BE, V76, P327, DOI 10.1016/j.pbb.2003.08.002
   HALTER JB, 1984, AM J PHYSIOL, V247, pE47, DOI 10.1152/ajpendo.1984.247.1.E47
   Harris RBS, 2004, PHYSIOL BEHAV, V81, P557, DOI 10.1016/j.physbeh.2004.01.017
   Holness MJ, 2007, AM J PHYSIOL-ENDOC M, V292, pE1087, DOI 10.1152/ajpendo.00375.2006
   KANT GJ, 1983, PSYCHONEUROENDOCRINO, V8, P421, DOI 10.1016/0306-4530(83)90021-5
   KANT GJ, 1993, PHYSIOL BEHAV, V54, P499, DOI 10.1016/0031-9384(93)90242-8
   KIROU I, 2006, ENDOCRINOL METAB, V1083, P77
   Kmiec Z, 2005, GERONTOLOGY, V51, P357, DOI 10.1159/000088698
   Kvetnansky R, 1995, ANN NY ACAD SCI, V771, P131, DOI 10.1111/j.1749-6632.1995.tb44676.x
   la Fleur SE, 2006, PHYSIOL BEHAV, V89, P110, DOI 10.1016/j.physbeh.2006.01.028
   Lemberger T, 1996, J BIOL CHEM, V271, P1764, DOI 10.1074/jbc.271.3.1764
   Levin BE, 2000, AM J PHYSIOL-REG I, V279, pR1357, DOI 10.1152/ajpregu.2000.279.4.R1357
   LEVINE AS, 1981, AM J PHYSIOL, V241, pR72, DOI 10.1152/ajpregu.1981.241.1.R72
   Makino S, 2002, BRAIN RES, V943, P216, DOI 10.1016/S0006-8993(02)02647-1
   Martin B, 2007, ENDOCRINOLOGY, V148, P4318, DOI 10.1210/en.2007-0161
   Morita M, 2000, CELL STRUCT FUNCT, V25, P309, DOI 10.1247/csf.25.309
   MORLEY JE, 1983, LIFE SCI, V32, P2169
   Oliver G, 2000, PSYCHOSOM MED, V62, P853, DOI 10.1097/00006842-200011000-00016
   Parker G, 2006, J AFFECT DISORDERS, V92, P149, DOI 10.1016/j.jad.2006.02.007
   Pecoraro N, 2005, PSYCHONEUROENDOCRINO, V30, P815, DOI 10.1016/j.psyneuen.2005.03.010
   Pecoraro N, 2004, ENDOCRINOLOGY, V145, P3754, DOI 10.1210/en.2004-0305
   PORTERFIELD S.P., 2001, Endocrine Physiology, Vsecond
   Sabban EL, 2007, STRESS, V10, P137, DOI 10.1080/10253890701404078
   Shigemura N, 2004, ENDOCRINOLOGY, V145, P839, DOI 10.1210/en.2003-0602
   Torres ILS, 2002, NEUROCHEM RES, V27, P519, DOI 10.1023/A:1019856821430
   Torres ILS, 2001, BRAZ J MED BIOL RES, V34, P111, DOI 10.1590/S0100-879X2001000200012
   Torres SJ, 2007, NUTRITION, V23, P887, DOI 10.1016/j.nut.2007.08.008
   Tsigos C, 2002, J PSYCHOSOM RES, V53, P865, DOI 10.1016/S0022-3999(02)00429-4
   Uhley VE, 1997, PHYSIOL BEHAV, V62, P617, DOI 10.1016/S0031-9384(97)00176-5
   YAMADA F, 1993, ENDOCRINOLOGY, V132, P2199, DOI 10.1210/en.132.5.2199
   Young JB, 2000, AM J PHYSIOL-REG I, V279, pR1745, DOI 10.1152/ajpregu.2000.279.5.R1745
   Zardooz H, 2006, PHYSIOL BEHAV, V89, P373, DOI 10.1016/j.physbeh.2006.06.023
   Zellner DA, 2006, PHYSIOL BEHAV, V87, P789, DOI 10.1016/j.physbeh.2006.01.014
   Zylan Kathleen D., 1996, Physiology and Behavior, V59, P165, DOI 10.1016/0031-9384(95)02039-X
NR 53
TC 21
Z9 25
U1 0
U2 11
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0195-6663
EI 1095-8304
J9 APPETITE
JI Appetite
PD NOV
PY 2008
VL 51
IS 3
BP 592
EP 598
DI 10.1016/j.appet.2008.04.016
PG 7
WC Behavioral Sciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Nutrition & Dietetics
GA 358PV
UT WOS:000259930900026
PM 18524415
DA 2025-06-11
ER

PT J
AU Godala, M
   Materek-Kusmierkiewicz, I
   Moczulski, D
   Rutkowski, M
   Szatko, F
   Gaszynska, E
   Tokarski, S
   Kowalski, J
AF Godala, Malgorzata
   Materek-Kusmierkiewicz, Izabela
   Moczulski, Dariusz
   Rutkowski, Maciej
   Szatko, Franciszek
   Gaszynska, Ewelina
   Tokarski, Slawomir
   Kowalski, Jan
TI The risk of plasma vitamin A, C, E and D deficiency in patients with
   metabolic syndrome: A case-control study
SO ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE metabolic syndrome; antioxidant vitamins; vitamin D deficiency
ID HYPOVITAMINOSIS-D; OXIDATIVE STRESS; ANTIOXIDANT CONCENTRATIONS;
   SUPPLEMENTATION; DIETARY; CAROTENOIDS; POPULATION; DISEASE; ADULTS;
   HEALTH
AB Background. The increasing incidence of metabolic diseases such as obesity or diabetes have made them a major public health problem. Increasing oxidative stress induced by reactive oxygen species, which initiate the oxidative adverse changes in the cell, is mentioned, among other risk factors, to underlie these diseases. Vitamin A, C and E are listed among the non-enzymatic mechanisms counteracting this phenomenon. Vitamin D deficiency is also associated with cardiovascular diseases.
   Objectives. The aim of the study was to assess the risk of vitamin A, C, E and D deficit in the plasma of metabolic syndrome (MS) patients.
   Material and methods. The study included 191 patients with MS and 98 subjects without MS. Log-linear analysis was used in the assessment of mutual interactions between the vitamin concentration and the analysis of classification by ROC curves to predict the frequency of vitamin deficiency in MS patients.
   Results. A correlation was found between the plasma level of vitamins in the group of MS patients. Vitamin A concentration correlated with that of vitamin C (r = 0.51, p = 0.0000), vitamin D (r = 0.49, p = 0.0000) and E (r = 0.32, p = 0.0001). The plasma level of vitamin D correlated with the level of vitamin E (r = 0.46, p = 0.00000) and vitamin C (r = 0.37, p = 0.0000). Regression analysis showed a correlation between the concentration of the tested vitamins in patients with MS. Interactions were observed between vitamins C and A and between C and D. HDL cholesterol level was lower in patients with vitamin A deficiency compared to patients with its normal level.
   Conclusions. The plasma levels of vitamin A, C, E and D were significantly lower in patients with MS than in healthy subjects and they mutually correlated with each other. The normalization of glucose and HDL level may contribute to the regulation of the concentration of vitamin A in patients with MS.
C1 [Godala, Malgorzata] Med Univ Lodz, Dept Nutr & Epidemiol, Chair Hyg & Epidemiol, Lodz, Poland.
   [Materek-Kusmierkiewicz, Izabela; Moczulski, Dariusz] Med Univ Lodz, Dept Internal Med & Nephrodiabetol, Chair Internal Dis & Cardiol, Lodz, Poland.
   [Rutkowski, Maciej] Med Univ Lodz, Dept Mil Toxicol & Radiol Protect, Lodz, Poland.
   [Szatko, Franciszek; Gaszynska, Ewelina] Med Univ Lodz, Chair Hyg & Epidemiol, Dept Hyg & Hlth Promot, Lodz, Poland.
   [Tokarski, Slawomir] Univ Rzeszow, Fac Med, Rzeszow, Poland.
   [Kowalski, Jan] Med Univ Lodz, Dept Internal & Infect Dis, Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz; Medical University
   Lodz; Medical University Lodz; University of Rzeszow; Medical University
   Lodz
RP Godala, M (corresponding author), Med Univ Lodz, Dept Nutr & Epidemiol, Chair Hyg & Epidemiol, Lodz, Poland.
EM malgorzata.godala@umed.lodz.pl
RI Godala, Malgorzata/S-9597-2016; Gaszynska, Ewelina/S-9946-2016;
   Kowalski, Jan/HDM-3504-2022
OI Tokarski, Slawomir/0000-0003-1153-0667; Moczulski,
   Dariusz/0000-0002-0926-9909; Godala, Malgorzata/0000-0003-3579-8537;
   Materek-Kusmierkiewicz, Izabela/0000-0001-5912-4516; Gaszynska,
   Ewelina/0000-0001-7568-3502
FU Medical University of Lodz [502-03/6-024-02/502-64-050]
FX The study was financed by the Medical University of Lodz (research task
   No: 502-03/6-024-02/502-64-050).
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Bergström T, 2011, MUTAGENESIS, V26, P735, DOI 10.1093/mutage/ger041
   Beydoun MA, 2011, J NUTR, V141, P903, DOI 10.3945/jn.110.136580
   Botella-Carretero JI, 2007, CLIN NUTR, V26, P573, DOI 10.1016/j.clnu.2007.05.009
   Cahill L, 2009, AM J EPIDEMIOL, V170, P464, DOI 10.1093/aje/kwp156
   Chiu KC, 2004, AM J CLIN NUTR, V79, P820
   Czernichow S, 2009, AM J CLIN NUTR, V90, P329, DOI 10.3945/ajcn.2009.27635
   Edge R, 1997, J PHOTOCH PHOTOBIO B, V41, P189, DOI 10.1016/S1011-1344(97)00092-4
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Forrest KYZ, 2011, NUTR RES, V31, P48, DOI 10.1016/j.nutres.2010.12.001
   Hyppönen E, 2007, AM J CLIN NUTR, V85, P860, DOI 10.1093/ajcn/85.3.860
   Illison VK, 2011, INT J VITAM NUTR RES, V81, P12, DOI 10.1024/0300-9831/a000046
   John WG, 2005, AM J CLIN NUTR, V82, P517, DOI 10.1093/ajcn/82.3.517
   Li Y, 2007, J NUTR, V137, P2171, DOI 10.1093/jn/137.10.2171
   Mayne ST, 2013, CANCER EPIDEM BIOMAR, V22, P2145, DOI 10.1158/1055-9965.EPI-13-1026
   Muldowney S, 2011, ANN NUTR METAB, V58, P85, DOI 10.1159/000324600
   Muscogiuri G, 2012, NUTR METAB CARDIOVAS, V22, P81, DOI 10.1016/j.numecd.2011.11.001
   Odum E P, 2012, Niger Postgrad Med J, V19, P199
   Palace VP, 1999, FREE RADICAL BIO MED, V26, P746, DOI 10.1016/S0891-5849(98)00266-4
   Pludowski P, 2013, ENDOKRYNOL POL, V64, P319, DOI 10.5603/EP.2013.0012
   Pocobelli G, 2009, AM J EPIDEMIOL, V170, P472, DOI 10.1093/aje/kwp167
   Rutkowski M, 2004, Z NATURFORSCH C, V59, P762
   Rutkowski M., 2006, Journal of Physiology and Pharmacology, V57, P221
   Rutkowski M., 2005, DIAGN LAB, V41, P375
   Sharma P, 2005, INDIAN J CLIN BIOCHE, V20, P145, DOI 10.1007/BF02893061
   SINGH RB, 1995, AM J CARDIOL, V76, P1233, DOI 10.1016/S0002-9149(99)80348-8
   Soni MG, 2010, TOXICOL SCI, V118, P348, DOI 10.1093/toxsci/kfq293
   Trasino SE, 2015, J BIOL CHEM, V290, P1456, DOI 10.1074/jbc.M114.616763
   Vacek JL, 2012, AM J CARDIOL, V109, P359, DOI 10.1016/j.amjcard.2011.09.020
   Vivekananthan DP, 2003, LANCET, V361, P2017, DOI 10.1016/S0140-6736(03)13637-9
NR 30
TC 53
Z9 59
U1 0
U2 11
PU WROCLAW MEDICAL UNIV
PI WROCLAW
PA UL K MARCINKOWSKIEGO 2-6, WROCLAW, 50-368, POLAND
SN 1899-5276
EI 2451-2680
J9 ADV CLIN EXP MED
JI Adv. Clin. Exp. Med.
PD JUL
PY 2017
VL 26
IS 4
BP 581
EP 586
DI 10.17219/acem/62453
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FF1MN
UT WOS:000408663700004
PM 28691410
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Durak, A
   Bitirim, CV
   Turan, B
AF Durak, Aysegul
   Bitirim, Ceylan, V
   Turan, Belma
TI Titin and CK2α are New Intracellular Targets in Acute Insulin
   Application-Associated Benefits on Electrophysiological Parameters of
   Left Ventricular Cardiomyocytes From Insulin-Resistant Metabolic
   Syndrome Rats
SO CARDIOVASCULAR DRUGS AND THERAPY
LA English
DT Article
DE Heart function; Left ventricular cardiomyocytes; Insulin resistance;
   Metabolic syndrome; Nitrosative stress; Cardiac electrophysiology
ID OXIDATIVE STRESS; HEART-RATE; CARDIOVASCULAR-DISEASE; CARDIAC
   DYSFUNCTION; DIABETES-MELLITUS; MESSENGER-RNA; RISK-FACTORS; GLUCOSE;
   REPERFUSION; EXPRESSION
AB Background Previous studies have demonstrated that a high-carbohydrate intake could induce metabolic syndrome (MetS) in male rats with marked cardiac functional abnormalities. In addition, studies mentioned some benefits of insulin application on these complications, but there are considerable disagreements among their findings. Therefore, we aimed to extend our knowledge on the in-vitro influence of insulin on left ventricular dysfunction and also in the isolated cardiomyocytes from MetS rats. Results At the organ function level, an acute insulin application (100-nM) provided an important beneficial effect on the left ventricular developed pressure in MetS rats. Furthermore, to treat the freshly isolated cardiomyocytes from MetS rats with insulin provided marked recoveries in elevated resting intracellular Ca2+-level, as well as significant prevention of prolonged action potential through an augmentation in depressed K+-channel currents. Insulin also normalized the cellular levels of increased ROS and phosphorylation of PKC alpha, together with normalizations of apoptotic markers in MetS cardiomyocytes through the insulin-mediated regulation of phospho-Akt. Since not only elevated PKC alpha-activity but also reductions in phospho-Akt are key modulators of titin-based cardiomyocyte stiffening in hyperglycemia, insulin treatment of the cardiomyocytes prevented the activation of titin via the above pathways. Furthermore, CK2 alpha-activation and NOS-phosphorylation could be prevented with insulin treatment. Mechanistically, we found that impaired insulin signaling and elevated PKC alpha and CK2 alpha activities, as well as depressed Akt phosphorylation, are key modulators of titin-based cardiomyocyte stiffening in MetS rats. Conclusion We propose that restoring normal kinase activities and also increases in phospho-Akt by insulin can contribute marked recoveries in MetS heart function, indicating a promising approach to modulate titin-associated factors in heart dysfunction associated with type-2 diabetes mellitus.
   Graphical
C1 [Durak, Aysegul; Turan, Belma] Ankara Univ, Fac Med, Dept Biophys, Ankara, Turkey.
   [Bitirim, Ceylan, V] Ankara Univ, Stem Cell Inst, Ankara, Turkey.
C3 Ankara University; Ankara University
RP Turan, B (corresponding author), Ankara Univ, Fac Med, Dept Biophys, Ankara, Turkey.
EM belma.turan@medicine.ankara.edu.tr
RI TURAN, Belma/AAG-8084-2020; BITIRIM, VERDA/A-6731-2018; durak,
   aysegul/AAA-7647-2022
OI Bitirim, Ceylan Verda/0000-0002-7979-0679
FU TUBITAK [SBAG214S254]
FX This study was funded by TUBITAK SBAG214S254 to Belma Turan.
CR AHMED SS, 1978, J CLIN INVEST, V61, P1123, DOI 10.1172/JCI109027
   [Anonymous], 2010, J BIOMED BIOTECHNOL, DOI 10.1155/2010/753675
   [Anonymous], 2016, CIRC RES, DOI DOI 10.1161/CIRCRESAHA.116.306206
   Aroor AR, 2012, HEART FAIL CLIN, V8, P609, DOI 10.1016/j.hfc.2012.06.005
   Bellavere F, 1996, DIABETIC MED, V13, P709, DOI 10.1002/(SICI)1096-9136(199608)13:8<709::AID-DIA158>3.0.CO;2-8
   Bilginoglu A, 2013, CARDIOVASC TOXICOL, V13, P138, DOI 10.1007/s12012-012-9192-9
   Bonds DE, 2010, BMJ-BRIT MED J, V340, DOI 10.1136/bmj.b4909
   Boudina S, 2009, CIRCULATION, V119, P1272, DOI 10.1161/CIRCULATIONAHA.108.792101
   Brenner RR, 2003, LIPIDS, V38, P733, DOI 10.1007/s11745-003-1121-x
   Brien SE, 2006, APPL PHYSIOL NUTR ME, V31, P40, DOI 10.1139/H05-024
   Cameron AJ, 2008, J INTERN MED, V264, P177, DOI 10.1111/j.1365-2796.2008.01935.x
   Castro JP, 2003, CURR HYPERTENS REP, V5, P393, DOI 10.1007/s11906-003-0085-y
   Cazorla O, 2000, CIRC RES, V86, P59, DOI 10.1161/01.RES.86.1.59
   Chinali M, 2008, J AM COLL CARDIOL, V52, P932, DOI 10.1016/j.jacc.2008.04.013
   DeBosch B, 2006, J BIOL CHEM, V281, P32841, DOI 10.1074/jbc.M513087200
   Degirmenci S, 2018, J TRACE ELEM MED BIO, V48, P202, DOI 10.1016/j.jtemb.2018.04.014
   Desrois M, 2004, CARDIOVASC RES, V61, P288, DOI 10.1016/j.cardiores.2003.11.021
   Dubó S, 2016, FRONT PHYSIOL, V7, DOI 10.3389/fphys.2016.00074
   Durak A, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0790-0
   Durak A, 2017, CAN J PHYSIOL PHARM, V95, P1335, DOI 10.1139/cjpp-2017-0054
   EBERLI FR, 1991, CIRC RES, V68, P466, DOI 10.1161/01.RES.68.2.466
   ECKEL J, 1980, BIOCHIM BIOPHYS ACTA, V629, P510, DOI 10.1016/0304-4165(80)90156-7
   Einhorn Daniel, 2003, Endocr Pract, V9, P237
   Eom GH, 2011, CIRCULATION, V123, P2392, DOI 10.1161/CIRCULATIONAHA.110.003665
   Fleming I, 1999, CARDIOVASC RES, V43, P532, DOI 10.1016/S0008-6363(99)00094-2
   Galassetti P, 2012, EXP DIABETES RES, DOI 10.1155/2012/943706
   Grundy SM, 2004, J CLIN ENDOCR METAB, V89, P2595, DOI 10.1210/jc.2004-0372
   Guo W, 2018, INT J BIOL SCI, V14, P369, DOI 10.7150/ijbs.24117
   Hansen BC, 1999, ANN NY ACAD SCI, V892, P1, DOI 10.1111/j.1749-6632.1999.tb07782.x
   Hausenloy DJ, 2007, HEART FAIL REV, V12, P217, DOI 10.1007/s10741-007-9026-1
   Hedhli N, 2005, CARDIOVASC RES, V68, P186, DOI 10.1016/j.cardiores.2005.06.025
   HENRY PD, 1974, AM J PHYSIOL, V226, P309, DOI 10.1152/ajplegacy.1974.226.2.309
   Holman RR, 2009, NEW ENGL J MED, V361, P1736, DOI 10.1056/NEJMoa0905479
   Huisamen B, 2003, MOL CELL BIOCHEM, V249, P31, DOI 10.1023/A:1024749614222
   Ilkun O, 2013, CURR PHARM DESIGN, V19, P4806, DOI 10.2174/1381612811319270003
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Ji LL, 2010, AM J PHYSIOL-ENDOC M, V298, pE871, DOI 10.1152/ajpendo.00623.2009
   Jonassen AK, 2001, CIRC RES, V89, P1191, DOI 10.1161/hh2401.101385
   Kizhakekuttu TJ, 2010, CARDIOVASC THER, V28, pe20, DOI 10.1111/j.1755-5922.2010.00137.x
   Klein LJ, 2010, NETH HEART J, V18, P255, DOI 10.1007/BF03091772
   Kolaczynski JW, 1996, DIABETES, V45, P699, DOI 10.2337/diabetes.45.5.699
   Korkmaz GG, 2013, METABOLISM, V62, P828, DOI 10.1016/j.metabol.2013.01.002
   Korkmaz-Icöz S, 2016, AM J PHYSIOL-HEART C, V311, pH958, DOI 10.1152/ajpheart.00956.2015
   Laaksonen DE, 2002, AM J EPIDEMIOL, V156, P1070, DOI 10.1093/aje/kwf145
   LAMANNA VR, 1981, AM J PHYSIOL, V240, pH636, DOI 10.1152/ajpheart.1981.240.4.H636
   Lebovitz HE, 2011, DIABETES CARE, V34, pS225, DOI 10.2337/dc11-s225
   LeWinter MM, 2014, J CARDIOVASC PHARM, V63, P207, DOI 10.1097/FJC.0000000000000007
   Li G, 2008, AM J PHYSIOL-HEART C, V294, pH74, DOI 10.1152/ajpheart.00675.2007
   Maier S, 1999, CARDIOVASC RES, V44, P390, DOI 10.1016/S0008-6363(99)00229-1
   Malik VS, 2010, CIRCULATION, V121, P1356, DOI 10.1161/CIRCULATIONAHA.109.876185
   Matsuzawa Y, 2011, J ATHEROSCLER THROMB, V18, P629, DOI 10.5551/jat.7922
   Meigs JB, 2002, AM J MANAG CARE, V8, pS283
   MOGENSEN CE, 1980, DIABETOLOGIA, V18, P453
   Morovati A, 2019, PHYTOTHER RES, V33, P3261, DOI 10.1002/ptr.6500
   Mozaffarian D, 2011, NEW ENGL J MED, V364, P2392, DOI 10.1056/NEJMoa1014296
   Okatan EN, 2016, CAN J PHYSIOL PHARM, V94, P1064, DOI 10.1139/cjpp-2015-0531
   Okatan EN, 2015, CAN J PHYSIOL PHARM, V93, P517, DOI 10.1139/cjpp-2014-0507
   Olgar Y, 2018, EXP GERONTOL, V110, P172, DOI 10.1016/j.exger.2018.06.012
   Ouwens DM, 2005, DIABETOLOGIA, V48, P1229, DOI 10.1007/s00125-005-1755-x
   Pagliassotti MJ, 1996, AM J PHYSIOL-REG I, V271, pR1319, DOI 10.1152/ajpregu.1996.271.5.R1319
   Palmer JL, 2008, ADV THER, V25, P752, DOI 10.1007/s12325-008-0080-4
   Qiao Q, 2007, ANN CLIN BIOCHEM, V44, P232, DOI 10.1258/000456307780480963
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Ruiz-Ramírez A, 2011, AM J PHYSIOL-ENDOC M, V301, pE1198, DOI 10.1152/ajpendo.00631.2010
   Springwald Anna, 2019, Pediatr Endocrinol Diabetes Metab, V25, P17, DOI 10.5114/pedm.2019.84711
   Srivastava AK, 2012, INDIAN J PHARMACOL, V44, P155, DOI 10.4103/0253-7613.93579
   SUTHERLAND C, 1993, BIOCHEM J, V296, P15, DOI 10.1042/bj2960015
   Szabó Z, 2001, CLIN SCI, V101, P37, DOI 10.1042/CS20010005
   Teshima Y, 2000, J MOL CELL CARDIOL, V32, P655, DOI 10.1006/jmcc.2000.1107
   Tian R, 2006, CIRC RES, V99, P3, DOI 10.1161/01.RES.0000233142.26369.f6
   Tumiel E, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00566
   Tuncay E, 2017, DIABETES, V66, P1346, DOI 10.2337/db16-1099
   Turan B, 1996, CARDIOVASC RES, V32, P351, DOI 10.1016/0008-6363(96)00071-5
   Vincent JL, 2010, CRIT CARE, V14, DOI 10.1186/cc8866
   von Lewinski D, 2005, CIRCULATION, V111, P2588, DOI 10.1161/CIRCULATIONAHA.104.497461
   Voulgari C, 2010, DIABETES-METAB RES, V26, P121, DOI 10.1002/dmrr.1063
   Wang TJ, 2007, CIRCULATION, V115, P1345, DOI 10.1161/CIRCULATIONAHA.106.655142
   Wilson PWF, 1999, ARCH INTERN MED, V159, P1104, DOI 10.1001/archinte.159.10.1104
   Wilson PWF, 2005, CIRCULATION, V112, P3066, DOI 10.1161/CIRCULATIONAHA.105.539528
   Yaras N, 2005, DIABETES, V54, P3082, DOI 10.2337/diabetes.54.11.3082
   Zhu CQ, 2017, BBA-MOL BASIS DIS, V1863, P2056, DOI 10.1016/j.bbadis.2016.11.008
NR 82
TC 9
Z9 9
U1 0
U2 3
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0920-3206
EI 1573-7241
J9 CARDIOVASC DRUG THER
JI Cardiovasc. Drugs Ther.
PD AUG
PY 2020
VL 34
IS 4
BP 487
EP 501
DI 10.1007/s10557-020-06974-2
EA MAY 2020
PG 15
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA MF1HU
UT WOS:000530768600001
PM 32377826
DA 2025-06-11
ER

PT J
AU Coskun, ZM
AF Coskun, Zeynep Mine
TI ER Stress Amelioration by Saxagliptin Protects the Liver Against
   Fructose-induced Insulin Resistance
SO ARCHIVES OF MEDICAL RESEARCH
LA English
DT Article
DE ER stress; Immunohistochemistry; Inflammation; Insulin resistance;
   Saxagliptin
ID ENDOPLASMIC-RETICULUM STRESS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   MODEL
AB Background/Aim. The study is aimed to demonstrate whether saxagliptin treatment may reduce endoplasmic reticulum (ER) stress, oxidative damage, and inflammation in the liver of fructose-induced insulin resistance (IR) rats.
   Material and Methods. Twenty-eight rats were divided as control, IR, saxagliptin treatment (ST) and IR+ST groups. IR caused by fructose (10%) administration for 10 weeks and, ST was administered for 15 d. The liver tissues were obtained from rats. ER stress markers were analyzed using Real-Time PCR. Oxidative stress was measured. The inflammation in the liver was detected by the streptavidin-biotin immunostaining method.
   Results. The values of total oxidant/antioxidant status were the same between control and IR rats. The numbers of IL-6, NF-kappa B and PPAR gamma immune(+) cells showed significant changes in the liver among four groups. The increased mRNA expression levels of ER stress and apoptosis markers as GRP78, PERK, IRE1 alpha, ATF-4 and -6, CHOP, Caspase-3, -8, -9 and -12 in IR reduced with ST.
   Conclusion. These findings indicate that saxagliptin treatment may ameliorate IR by reducing ER stress rather than inflammation and oxidative stress in the liver. (C) 2020 IMSS. Published by Elsevier Inc.
C1 [Coskun, Zeynep Mine] Demiroglu Bilim Univ, Fac Arts & Sci, Dept Mol Biol & Genet, TR-34394 Istanbul, Turkey.
C3 Demiroglu Bilim University
RP Coskun, ZM (corresponding author), Demiroglu Bilim Univ, Fac Arts & Sci, Dept Mol Biol & Genet, TR-34394 Istanbul, Turkey.
EM zeynepminecoskun@gmail.com
RI coskun, zeynep/AAV-1778-2021
OI COSKUN YAZICI, Zeynep Mine/0000-0003-4791-6537
FU Istanbul University; Cerrahpasa; Demiroglu Bilim University
FX The author thanks Istanbul University, Cerrahpasa and Demiroglu Bilim
   University for their supports.
CR BEUTLER E, 1963, J LAB CLIN MED, V61, P882
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Castro MC, 2015, LIFE SCI, V137, P1, DOI 10.1016/j.lfs.2015.07.010
   Chen KL, 2018, METAB SYNDR RELAT D, V16, P336, DOI 10.1089/met.2018.0010
   Chen L, 2015, INT J ENDOCRINOL, V2015, DOI 10.1155/2015/508409
   Cioffi F, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040323
   Czerska M, 2015, MED PR, V66, P393, DOI 10.13075/mp.5893.00137
   El-Fawal R, 2018, BIOMED PHARMACOTHER, V102, P930, DOI 10.1016/j.biopha.2018.03.162
   Elrod HA, 2008, PPAR RES, V2008, DOI 10.1155/2008/704165
   Farooqui AA, 2012, CELL MOL LIFE SCI, V69, P741, DOI 10.1007/s00018-011-0840-1
   Flamment M, 2012, TRENDS ENDOCRIN MET, V23, P381, DOI 10.1016/j.tem.2012.06.003
   Ghemrawi R, 2018, CELLS-BASEL, V7, DOI 10.3390/cells7060063
   Helal MG, 2019, LIFE SCI, V239, DOI 10.1016/j.lfs.2019.117017
   Hussain T, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/7432797
   Iurlaro R, 2016, FEBS J, V283, P2640, DOI 10.1111/febs.13598
   Jegatheesan P, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030230
   Jensen T, 2018, J HEPATOL, V68, P1063, DOI 10.1016/j.jhep.2018.01.019
   Jung YA, 2014, DIABETES RES CLIN PR, V105, P47, DOI 10.1016/j.diabres.2014.04.028
   Kennedy D, 2015, METHODS MOL BIOL, V1292, P3, DOI 10.1007/978-1-4939-2522-3_1
   LEDWOZYW A, 1986, CLIN CHIM ACTA, V155, P275, DOI 10.1016/0009-8981(86)90247-0
   Lepretti M, 2018, NUTRIENTS, V10, DOI 10.3390/nu10030350
   Nephan G, 2018, CELL BIOCHEM FUNCT, V36, P212, DOI 10.1002/cbf.3333
   Nourooz-Zadeh J, 1999, METHOD ENZYMOL, V300, P58
   Onyango AN, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/4321714
   Pan Y, 2018, PHARMACOL RES, V130, P438, DOI 10.1016/j.phrs.2018.02.020
   Pfaffl MW, 2001, NUCLEIC ACIDS RES, V29, DOI 10.1093/nar/29.9.e45
   Plaisance V, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0163046
   Pujadas G, 2017, ENDOCRINE, V56, P509, DOI 10.1007/s12020-016-1052-0
   REZNICK AZ, 1994, METHOD ENZYMOL, V233, P357
   Roberts CK, 2013, COMPR PHYSIOL, V3, P1, DOI 10.1002/cphy.c110062
   Ryoo HD, 2016, FEBS J, V283, P3718, DOI 10.1111/febs.13755
   SEDLAK J, 1968, ANAL BIOCHEM, V25, P192, DOI 10.1016/0003-2697(68)90092-4
   SUN Y, 1988, CLIN CHEM, V34, P497
   Tappy L, 2018, J EXP BIOL, V221, DOI 10.1242/jeb.164202
   Taylor R, 2012, DIABETES, V61, P778, DOI 10.2337/db12-0073
   Wang NN, 2018, J NUTR BIOCHEM, V57, P180, DOI 10.1016/j.jnutbio.2018.03.018
   Wang YY, 2014, CHINESE MED J-PEKING, V127, P1744, DOI 10.3760/cma.j.issn.0366-6999.20132924
   Xu CY, 2005, J CLIN INVEST, V115, P2656, DOI 10.1172/JCI26373
   Yi SY, 2017, FRONT NEUROSCI-SWITZ, V11, DOI 10.3389/fnins.2017.00152
   Yilmaz S, 2015, REDOX REP, V20, P97, DOI 10.1179/1351000214Y.0000000110
   Zhang KZ, 2008, NATURE, V454, P455, DOI 10.1038/nature07203
   Zhang XQ, 2014, WORLD J GASTROENTERO, V20, P1768, DOI 10.3748/wjg.v20.i7.1768
NR 42
TC 5
Z9 5
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0188-4409
EI 1873-5487
J9 ARCH MED RES
JI Arch. Med. Res.
PD MAY
PY 2020
VL 51
IS 4
BP 303
EP 309
DI 10.1016/j.arcmed.2020.03.007
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA LW0CE
UT WOS:000538813800003
PM 32223915
DA 2025-06-11
ER

PT J
AU Makhtoomi, M
   Shateri, Z
   Mashoufi, A
   Nouri, M
   Honarvar, B
   Keshani, P
AF Makhtoomi, Maede
   Shateri, Zainab
   Mashoufi, Ava
   Nouri, Mehran
   Honarvar, Behnam
   Keshani, Parisa
TI The association between dietary polyphenol intake and the odds of
   metabolic syndrome
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Polyphenols; Metabolic syndrome; Waist circumference; Triglyceride;
   Fasting blood sugar; High-density lipoprotein cholesterol; Blood
   pressure
ID CARDIOVASCULAR RISK-FACTORS; MEDITERRANEAN DIET; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; FLAVONOID INTAKE; GLYCEMIC CONTROL; METAANALYSIS;
   MECHANISMS; WOMEN; HEALTH
AB Oxidative stress plays a role in the pathophysiology of metabolic syndrome (MetS), and one of the most important features of polyphenols is their antioxidant properties. However, there is no universal consensus on the effectiveness of polyphenols in treating Mets. Therefore, the present study aimed to investigate the association between polyphenols and MetS in an Iranian sample. This cross-sectional study was conducted on an adult population sample from Shiraz, in southern Iran. MetS was calculated using the criteria of the Adult Treatment Panel III (ATP III), which defines MetS as the presence of three or more of the specified risk factors. A validated food frequency questionnaire (FFQ) was used to measure the participant's food intake. The association between polyphenol intake and the odds on MetS and its components was assessed using logistic regression. In both univariate and multivariate models, the association between polyphenol intake and the risk of MetS was not significant. However, after adjusting for potential confounders in the multivariate model, each unit change in flavonol, flavanone and isoflavones intake was associated with a lower, higher, and higher odds of MetS, respectively (flavonols: odds ratio (OR) = 0.926, 95% confidence interval (CI) 0.891-0.963, P < 0.001-flavanones: OR = 1.007, 95% CI: 1.001-1.014, P = 0.034-isoflavones: OR = 4.920, 95% CI: 1.057-22.894, P = 0.042). Additionally, no significant association was found between polyphenol intake and the risk of MetS components. However, in the multivariate model, after adjusting for potential confounders, a significant association was observed between polyphenol intake and lower odds of high waist circumference (OR = 0.998, 95% CI: 0.996-0.999, P = 0.032). The present study did not reveal a significant association between overall polyphenol intake and the odds of MetS. However, certain subclasses of polyphenols appear to be associated with the likelihood of MetS and its components.
C1 [Makhtoomi, Maede] Shiraz Univ, Med Sci, Student Res Comm, Shiraz, Iran.
   [Makhtoomi, Maede; Honarvar, Behnam; Keshani, Parisa] Shiraz Univ Med Sci, Inst Hlth, Hlth Policy Res Ctr, Shiraz, Iran.
   [Shateri, Zainab] Ilam Univ Med Sci, Sch Med, Dept Nutr & Biochem, Ilam, Iran.
   [Mashoufi, Ava] Shiraz Univ Med Sci, Dept Community Nutr, Sch Nutr & Food Sci, Shiraz, Iran.
   [Nouri, Mehran] Babol Univ Med Sci, Hlth Res Inst, Cellular & Mol Biol Res Ctr, Babol, Iran.
C3 Shiraz University; Shiraz University of Medical Science; Shiraz
   University of Medical Science; Babol University of Medical Sciences
RP Keshani, P (corresponding author), Shiraz Univ Med Sci, Inst Hlth, Hlth Policy Res Ctr, Shiraz, Iran.; Nouri, M (corresponding author), Babol Univ Med Sci, Hlth Res Inst, Cellular & Mol Biol Res Ctr, Babol, Iran.
EM mehran_nouri71@yahoo.com; parisa.keshani@gmail.com
RI Honarvar, Behnam/K-1623-2013
OI Shateri, Zainab/0000-0003-3725-6686
CR Akilen R, 2012, CLIN NUTR, V31, P609, DOI 10.1016/j.clnu.2012.04.003
   Amiot MJ, 2016, OBES REV, V17, P573, DOI 10.1111/obr.12409
   Andriantsitohaina R, 2012, BRIT J NUTR, V108, P1532, DOI 10.1017/S0007114512003406
   Basu A, 2011, NUTRITION, V27, P206, DOI 10.1016/j.nut.2010.01.015
   Cassidy A, 2011, AM J CLIN NUTR, V93, P338, DOI 10.3945/ajcn.110.006783
   Chiva-Blanch G, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/5812401
   de Kleijn MJJ, 2002, J NUTR, V132, P276, DOI 10.1093/jn/132.2.276
   Del Rio D, 2013, ANTIOXID REDOX SIGN, V18, P1818, DOI 10.1089/ars.2012.4581
   Driessen MT, 2009, EUR J CLIN NUTR, V63, P536, DOI 10.1038/ejcn.2008.6
   Farmanfarma KK, 2019, DIABETES METAB SYND, V13, P792, DOI 10.1016/j.dsx.2018.11.055
   Finicelli M, 2019, J CELL PHYSIOL, V234, P5807, DOI 10.1002/jcp.27506
   Fraga LN, 2021, FOOD FUNCT, V12, P11278, DOI [10.1039/d1fo02664j, 10.1039/D1FO02664J]
   Goodman-Gruen D, 2001, J NUTR, V131, P1202, DOI 10.1093/jn/131.4.1202
   Grosso G, 2017, EUR J NUTR, V56, P1409, DOI 10.1007/s00394-016-1187-z
   Grosso G, 2014, CURR PHARM DESIGN, V20, P5039, DOI 10.2174/1381612819666131206112144
   Grosso G, 2014, CRIT REV FOOD SCI, V54, P593, DOI 10.1080/10408398.2011.596955
   Hejazi J, 2022, INT J FOOD SCI NUTR, V73, P116, DOI 10.1080/09637486.2021.1928008
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Jung UJ, 2003, CLIN NUTR, V22, P561, DOI 10.1016/S0261-5614(03)00059-1
   Kim K, 2016, BRIT J NUTR, V115, P1481, DOI 10.1017/S0007114516000519
   Knekt P, 2002, AM J CLIN NUTR, V76, P560, DOI 10.1093/ajcn/76.3.560
   Lakka TA, 2003, MED SCI SPORT EXER, V35, P1279, DOI 10.1249/01.MSS.0000079076.74931.9A
   Landberg R, 2011, J NUTR, V141, P618, DOI 10.3945/jn.110.133843
   Lee SH, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081755
   Liu IM, 2007, LIFE SCI, V81, P1479, DOI 10.1016/j.lfs.2007.08.045
   Liu K, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/6713194
   Liu YJ, 2014, CLIN NUTR, V33, P59, DOI 10.1016/j.clnu.2013.03.011
   Marseglia L, 2015, INT J MOL SCI, V16, P378, DOI 10.3390/ijms16010378
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   Medina-Remón A, 2017, BRIT J CLIN PHARMACO, V83, P114, DOI 10.1111/bcp.12986
   Mirmiran P, 2010, PUBLIC HEALTH NUTR, V13, P654, DOI 10.1017/S1368980009991698
   Munir KM, 2013, AM J PHYSIOL-ENDOC M, V305, pE679, DOI 10.1152/ajpendo.00377.2013
   Nolan Paul B, 2017, Prev Med Rep, V7, P211, DOI 10.1016/j.pmedr.2017.07.004
   Oh JS, 2016, NUTR RES PRACT, V10, P67, DOI 10.4162/nrp.2016.10.1.67
   Onakpoya IJ, 2015, J HUM HYPERTENS, V29, P77, DOI 10.1038/jhh.2014.46
   Popiolek-Kalisz J, 2023, NUTRIENTS, V15, DOI 10.3390/nu15040854
   Rizza S, 2011, J CLIN ENDOCR METAB, V96, pE782, DOI 10.1210/jc.2010-2879
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Rodrigo R, 2012, ADV CLIN CHEM, V58, P225, DOI 10.1016/B978-0-12-394383-5.00014-X
   Rothwell JA, 2013, DATABASE-OXFORD, DOI 10.1093/database/bat070
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Torres S, 2019, EUR J NUTR, V58, P27, DOI 10.1007/s00394-018-1790-2
   van der Schouw YT, 2005, J NUTR, V135, P260, DOI 10.1093/jn/135.2.260
   Xu Q, 2012, NUTR RES, V32, P648, DOI 10.1016/j.nutres.2012.07.002
   Zhang JN, 2018, J AGR FOOD CHEM, V66, P12412, DOI 10.1021/acs.jafc.8b03574
   Zhang YB, 2013, NUTRITION, V29, P8, DOI 10.1016/j.nut.2012.03.019
   Zhao ZL, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1195107
   Zheng XX, 2013, AM J CLIN NUTR, V97, P750, DOI 10.3945/ajcn.111.032573
NR 48
TC 1
Z9 1
U1 2
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD OCT 26
PY 2024
VL 14
IS 1
AR 25559
DI 10.1038/s41598-024-77335-4
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA K4P0V
UT WOS:001343699800015
PM 39462087
OA gold
DA 2025-06-11
ER

PT J
AU Simao, ANC
   Lozovoy, MAB
   Simao, TNC
   Venturini, D
   Barbosa, DS
   Dichi, JB
   Matsuo, T
   Cecchini, R
   Dichi, I
AF Simao, A. N. C.
   Lozovoy, M. A. B.
   Simao, T. N. C.
   Venturini, D.
   Barbosa, D. S.
   Dichi, J. B.
   Matsuo, T.
   Cecchini, R.
   Dichi, I.
TI Immunological and biochemical parameters of patients with metabolic
   syndrome and the participation of oxidative and nitroactive stress
SO BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
LA English
DT Article
DE Metabolic syndrome; Uric acid; Inflammation; Adiponectin; Nitric oxide;
   Lipoperoxidation
ID NITRIC-OXIDE METABOLITES; TUMOR-NECROSIS-FACTOR; URIC-ACID;
   INSULIN-RESISTANCE; OBESITY; INTERLEUKIN-6; ADIPONECTIN; MARKERS;
   INFLAMMATION; REDUCTION
AB Metabolic syndrome (MS) is a multifactorial disease involving inflammatory activity and endothelial dysfunction. The aim of the present study was to evaluate the relationship between the changes in lipoperoxidation, in immunological and biochemical parameters and in nitric oxide metabolite (NOx) levels in MS patients. Fifty patients with MS (4 males/46 females) and 50 controls (3 males/47 females) were studied. Compared to control (Mann-Whitney test), MS patients presented higher serum levels (P < 0.05) of fibrinogen: 314 (185-489) vs 262 (188-314) mg/dL, C-reactive protein (CRP): 7.80 (1.10-46.50) vs 0.70 (0.16-5.20) mg/dL, interleukin-6: 3.96 (3.04-28.18) vs 3.33 (2.55-9.63) pg/mL, uric acid: 5.45 (3.15-9.65) vs 3.81 (2.70-5.90) mg/dL, and hydroperoxides: 20,689 (19,076-67,182) vs 18,636 (15,926-19,731) cpm. In contrast, they presented lower (P < 0.05) adiponectin: 7.11 (3.19-18.22) vs 12.31 (9.11-27.27) mu g/mL, and NOx levels: 5.69 (2.36-8.18) vs 6.72 (5.14-12.43) mu M. NOx was inversely associated (Spearman's rank correlation) with body mass index (r = -0.2858, P = 0.0191), insulin resistance determined by the homeostasis model assessment (r = -0.2530, P = 0.0315), CRP (r = -0.2843, P = 0.0171) and fibrinogen (r = -0.2464, P = 0.0413), and positively correlated with hydroperoxides (r = 0.2506, P = 0.0408). In conclusion, NOx levels are associated with obesity, insulin resistance, oxidative stress, and inflammatory markers. The high uric acid levels together with reactive oxygen species generation may be responsible for the reduced NO levels, which in turn lead to endothelial dysfunction. The elevated plasma chemiluminescence reflecting both increased plasma oxidation and reduced antioxidant capacity may play a role in the MS mechanism.
C1 [Simao, A. N. C.; Venturini, D.; Barbosa, D. S.] Univ Estadual Londrina, Dept Patol Anal Clin & Toxicol, BR-86038440 Londrina, PR, Brazil.
   [Lozovoy, M. A. B.] Univ Norte Parana, Dept Anal Clin, Londrina, PR, Brazil.
   [Simao, T. N. C.] Univ Norte Parana, Dept Clin Nutr, Londrina, PR, Brazil.
   [Dichi, J. B.; Dichi, I.] Univ Estadual Londrina, Dept Clin Med, BR-86038440 Londrina, PR, Brazil.
   [Matsuo, T.] Univ Estadual Londrina, Dept Estat, BR-86038440 Londrina, PR, Brazil.
   [Cecchini, R.] Univ Estadual Londrina, Dept Ciencias Patol, BR-86038440 Londrina, PR, Brazil.
C3 Universidade Estadual de Londrina; University Norte Parana; University
   Norte Parana; Universidade Estadual de Londrina; Universidade Estadual
   de Londrina; Universidade Estadual de Londrina
RP Simao, ANC (corresponding author), Univ Estadual Londrina, Dept Patol Anal Clin & Toxicol, Ave Robert Koch 60, BR-86038440 Londrina, PR, Brazil.
EM deianame@yahoo.com.br
RI Venturini, Danielle/HPH-1330-2023; Lozovoy, Marcell/AAM-4897-2021;
   Simão, Andrea/AAM-4892-2021; Barbosa, Décio/AAE-6351-2019; Cecchini,
   Rubens/D-9811-2013
OI Cecchini, Rubens/0000-0001-9941-2344
FU CNPq
FX Research supported by CNPq.
CR Asl SZ, 2008, CLIN BIOCHEM, V41, P1342, DOI 10.1016/j.clinbiochem.2008.08.076
   Casado MF, 2007, FOOD CHEM TOXICOL, V45, P945, DOI 10.1016/j.fct.2006.12.001
   CECCHINI R, 1990, FREE RADICAL RES COM, V10, P245, DOI 10.3109/10715769009149893
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Simao ANC, 2008, NUTRITION, V24, P675, DOI 10.1016/j.nut.2008.03.021
   Esposito K, 2006, J ENDOCRINOL INVEST, V29, P791, DOI 10.1007/BF03347372
   FLECHA BG, 1991, FREE RADICAL BIO MED, V10, P93
   Fried SK, 1998, J CLIN ENDOCR METAB, V83, P847, DOI 10.1210/jc.83.3.847
   Gersch C, 2008, NUCLEOS NUCLEOT NUCL, V27, P967, DOI 10.1080/15257770802257952
   Ghasemi A, 2010, CLIN BIOCHEM, V43, P89, DOI 10.1016/j.clinbiochem.2009.09.011
   Guevara I, 1998, CLIN CHIM ACTA, V274, P177, DOI 10.1016/S0009-8981(98)00060-6
   Gunnett CA, 2003, STROKE, V34, P2970, DOI 10.1161/01.STR.0000099123.55171.3F
   Haffner SM, 2003, AM J CARDIOL, V92, p18J, DOI 10.1016/S0002-9149(03)00612-X
   Imaram W, 2010, FREE RADICAL BIO MED, V49, P275, DOI 10.1016/j.freeradbiomed.2010.04.010
   Johnson RJ, 2009, AM J HYPERTENS, V22, P952, DOI 10.1038/ajh.2009.117
   Kern PA, 2001, AM J PHYSIOL-ENDOC M, V280, pE745
   Lee KU, 2001, DIABETES RES CLIN PR, V54, pS29, DOI 10.1016/S0168-8227(01)00332-1
   Li R, 2007, AM J PHYSIOL-ENDOC M, V293, pE1703, DOI 10.1152/ajpendo.00462.2007
   Lin LY, 2007, ATHEROSCLEROSIS, V190, P436, DOI 10.1016/j.atherosclerosis.2006.02.033
   Matsushita K, 2006, ARTERIOSCL THROM VAS, V26, P871, DOI 10.1161/01.ATV.0000208363.85388.8f
   Mohamed-Ali V, 1997, J CLIN ENDOCR METAB, V82, P4196, DOI 10.1210/jc.82.12.4196
   Nakagawa T, 2006, AM J PHYSIOL-RENAL, V290, pF625, DOI 10.1152/ajprenal.00140.2005
   Nathan C, 1997, J CLIN INVEST, V100, P2417, DOI 10.1172/JCI119782
   Navarro-Gonzálvez JA, 1998, CLIN CHEM, V44, P679
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Santos AC, 2005, INT J OBESITY, V29, P1452, DOI 10.1038/sj.ijo.0803035
   Skalicky J, 2008, CLIN CHEM LAB MED, V46, P499, DOI 10.1515/CCLM.2008.096
   Sun Ya-xun, 2006, Zhejiang Da Xue Xue Bao Yi Xue Ban, V35, P315
   Tao L, 2007, CIRCULATION, V115, P1408, DOI 10.1161/CIRCULATIONAHA.106.666941
   Urakawa H, 2003, J CLIN ENDOCR METAB, V88, P4673, DOI 10.1210/jc.2003-030202
   Williams IL, 2002, INT J OBESITY, V26, P754, DOI 10.1038/sj.ijo.0801995
   Yamaguchi Y, 2006, NITRIC OXIDE-BIOL CH, V15, P380, DOI 10.1016/j.niox.2006.04.264
   Zharikov S, 2008, AM J PHYSIOL-CELL PH, V295, pC1183, DOI 10.1152/ajpcell.00075.2008
NR 33
TC 15
Z9 15
U1 0
U2 5
PU ASSOC BRAS DIVULG CIENTIFICA
PI RIBEIRAO PRETO
PA FACULDADE MEDICINA, CASA 10, 14049 RIBEIRAO PRETO, RIBEIRAO PRETO, SP
   14049, BRAZIL
SN 0100-879X
EI 1414-431X
J9 BRAZ J MED BIOL RES
JI Brazilian J. Med. Biol. Res.
PD JUL
PY 2011
VL 44
IS 7
BP 707
EP 712
DI 10.1590/S0100-879X2011007500069
PG 6
WC Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Research & Experimental
   Medicine
GA 804KC
UT WOS:000293651700015
PM 21625822
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kiran, TR
   Otlu, O
   Karabulut, AB
AF Kiran, Tugba Raika
   Otlu, Onder
   Karabulut, Aysun Bay
TI Oxidative stress and antioxidants in health and disease
SO JOURNAL OF LABORATORY MEDICINE
LA English
DT Review
DE antioxidants; diseases; free radicals; nitrogen oxygen species;
   oxidative stress; reactive oxygen species
ID NITRIC-OXIDE; GLUTATHIONE-PEROXIDASE; FREE-RADICALS; MITOCHONDRIA;
   DAMAGE; MECHANISMS; GENERATION; ROS
AB The increase in the formation of reactive oxygen and reactive nitrogen species of endogenous or exogenous origin causes oxidative stress due to pro-oxidant and antioxidant imbalance that causes cellular damage in metabolism. This can increase inflammation of cells, apoptosis and necrosis, damage to DNA base damage, DNA and protein cross-links, lipid membrane peroxidation, and mitochondrial dysfunction. Antioxidants can be described as a system that protects biomolecules and the organism against the harmful effects of free radicals, reduces or repairs the damage done by reactive oxygen species (ROS) to the target molecule, and this is called antioxidant defense. It is known that the mechanisms caused by the increase in ROS resulting from oxidative stress are positively related to the pathology of many diseases such as cancer, metabolic syndrome, atherosclerosis, malaria, Alzheimer's disease, rheumatoid arthritis, neurodegenerative diseases and preeclampsia.
C1 [Kiran, Tugba Raika; Otlu, Onder] Malatya Turgut Ozal Univ, Med Biochem Dept, Fac Med, Malatya, Turkiye.
   [Karabulut, Aysun Bay] Ankara Yildirim Beyazit Univ, Med Biochem Dept, Fac Med, Ankara, Turkiye.
C3 Malatya Turgut Ozal University; Ankara Yildirim Beyazit University
RP Kiran, TR (corresponding author), Malatya Turgut Ozal Univ, Med Biochem Dept, Fac Med, Malatya, Turkiye.
EM raika.kiran@ozal.edu.tr
RI KIRAN, TUGBA/AAA-8224-2021; Otlu, Onder/W-3887-2018
OI KIRAN, TUGBA RAIKA/0000-0002-3724-0249; Otlu, Onder/0000-0001-5958-7609
CR Allegra M, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10121955
   Ally A, 2020, NITRIC OXIDE-BIOL CH, V102, P52, DOI 10.1016/j.niox.2020.06.004
   Ansari MY, 2020, BIOMED PHARMACOTHER, V129, DOI 10.1016/j.biopha.2020.110452
   Antunes F, 2002, FREE RADICAL BIO MED, V33, P1260, DOI 10.1016/S0891-5849(02)01016-X
   Arfin S, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10050642
   Asantewaa G, 2021, CURR OPIN BIOTECH, V68, P292, DOI 10.1016/j.copbio.2021.03.001
   Avery SV, 2011, BIOCHEM J, V434, P201, DOI 10.1042/BJ20101695
   Baek J, 2016, REDOX REP, V21, P164, DOI 10.1179/1351000215Y.0000000015
   Ballatori N, 2009, BIOL CHEM, V390, P191, DOI 10.1515/BC.2009.033
   Barber D A, 1994, Am Pharm, VNS34, P26
   Benchoam D, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8020048
   Betteridge DJ, 2000, METABOLISM, V49, P3, DOI 10.1016/S0026-0495(00)80077-3
   Biller JD, 2018, AN ACAD BRAS CIENC, V90, P3403, DOI 10.1590/0001-3765201820170730
   BISBY RH, 1990, FREE RADICAL RES COM, V8, P299, DOI 10.3109/10715769009053363
   Bjorklund G, 2020, MOL NEUROBIOL, V57, P2314, DOI 10.1007/s12035-019-01742-2
   Brigelius-Flohé R, 2013, BBA-GEN SUBJECTS, V1830, P3289, DOI 10.1016/j.bbagen.2012.11.020
   Bruckdorfer Richard, 2005, Molecular Aspects of Medicine, V26, P3, DOI 10.1016/j.mam.2004.09.002
   Chattopadhyay M, 2015, MOL CELL BIOCHEM, V399, P95, DOI 10.1007/s11010-014-2236-7
   Cho KJ, 2011, MOL CELLS, V32, P1, DOI 10.1007/s10059-011-1021-7
   Couto N, 2016, FREE RADICAL BIO MED, V95, P27, DOI 10.1016/j.freeradbiomed.2016.02.028
   Daenen K, 2019, PEDIATR NEPHROL, V34, P975, DOI 10.1007/s00467-018-4005-4
   Davies MJ, 2003, BIOCHEM BIOPH RES CO, V305, P761, DOI 10.1016/S0006-291X(03)00817-9
   De Luca MN, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10081283
   Dubois-Deruy E, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9090864
   Fleury C, 2002, BIOCHIMIE, V84, P131, DOI 10.1016/S0300-9084(02)01369-X
   FLORENCE TM, 1995, AUST NZ J OPHTHALMOL, V23, P3, DOI 10.1111/j.1442-9071.1995.tb01638.x
   Forman Henry Jay, 2008, P1, DOI 10.1007/978-1-4020-8399-0_1
   Fujii J, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11030501
   Garcia V, 2019, BRIT J PHARMACOL, V176, P189, DOI 10.1111/bph.14522
   Gebicka L, 2019, J INORG BIOCHEM, V197, DOI 10.1016/j.jinorgbio.2019.110699
   Gensert JM, 2006, ANTIOXID REDOX SIGN, V8, P919, DOI 10.1089/ars.2006.8.919
   Gromer S, 2004, MED RES REV, V24, P40, DOI 10.1002/med.10051
   Gulcin I, 2020, ARCH TOXICOL, V94, P651, DOI 10.1007/s00204-020-02689-3
   Guler C, 2015, ANGLE ORTHOD, V85, P239, DOI 10.2319/110113-798.1
   Gyurászová M, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/5478708
   Hacisevki A., 2009, J. Fac. Pharm, V38, P233, DOI [DOI 10.1501/ECZFAK0000000528, DOI 10.1501/ECZFAK_0000000528]
   Hajam YA, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11030552
   Halliwell B, 2007, BIOCHEM SOC T, V35, P1147, DOI 10.1042/BST0351147
   Halliwell B., 2015, Free Radicals in Biology and Medicine
   Hao Y, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.711060
   Hauck AK, 2019, J BIOL CHEM, V294, P1083, DOI 10.1074/jbc.R118.003214
   Hayes JD, 2005, ANNU REV PHARMACOL, V45, P51, DOI 10.1146/annurev.pharmtox.45.120403.095857
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   Hougland JL, 2013, MOLECULAR BASIS OF OXIDATIVE STRESS: CHEMISTRY, MECHANISMS, AND DISEASE PATHOGENESIS, P71
   Ito F, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8030072
   Juan CA, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22094642
   Karabulut AB, 2014, FOOD CHEM TOXICOL, V70, P128, DOI 10.1016/j.fct.2014.04.036
   Kawata A, 2018, IN VIVO, V32, P255, DOI 10.21873/invivo.11232
   Konno T, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10020233
   Koppers AJ, 2008, J CLIN ENDOCR METAB, V93, P3199, DOI 10.1210/jc.2007-2616
   Kurus M, 2017, ANDROLOGIA, V49, DOI 10.1111/and.12674
   Lakey-Beitia J, 2021, J ALZHEIMERS DIS, V82, pS335, DOI 10.3233/JAD-200185
   Le NA, 2016, REACTIVE OXYGEN SPEC, P67
   Li XY, 2013, J HEMATOL ONCOL, V6, DOI 10.1186/1756-8722-6-19
   Liaudet Lucas, 2009, Front Biosci (Landmark Ed), V14, P4809, DOI 10.2741/3569
   Lopert P, 2014, J BIOL CHEM, V289, P15611, DOI 10.1074/jbc.M113.533653
   Manna P, 2015, METAB SYNDR RELAT D, V13, P423, DOI 10.1089/met.2015.0095
   Margis R, 2008, FEBS J, V275, P3959, DOI 10.1111/j.1742-4658.2008.06542.x
   Martemucci G., 2022, Oxygen, V2, P48, DOI [10.3390/oxygen2020006, DOI 10.3390/OXYGEN2020006, 10.3390/]
   Martín-Sierra C, 2019, REDOX BIOL, V23, DOI 10.1016/j.redox.2019.101103
   Mateen S, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0152925
   Mieyal JJ, 2008, ANTIOXID REDOX SIGN, V10, P1941, DOI 10.1089/ars.2008.2089
   Mohammadi M, 2019, INT J PREVENTIVE MED, V10, DOI 10.4103/ijpvm.IJPVM_576_17
   Niki E, 2005, BIOCHEM BIOPH RES CO, V338, P668, DOI 10.1016/j.bbrc.2005.08.072
   NIKI E, 1991, AM J CLIN NUTR, V54, pS1119, DOI 10.1093/ajcn/54.6.1119s
   Pacher P, 2007, PHYSIOL REV, V87, P315, DOI 10.1152/physrev.00029.2006
   Perrotte M, 2016, OXID STRESS APPL BAS, P377, DOI 10.1007/978-3-319-33486-8_19
   Pham-Huy L.A., 2008, INT J BIOMED SCI, V4, P89, DOI DOI 10.59566/IJBS.2008.4089
   Phaniendra A, 2015, INDIAN J CLIN BIOCHE, V30, P11, DOI 10.1007/s12291-014-0446-0
   Pisoschi AM, 2021, EUR J MED CHEM, V209, DOI 10.1016/j.ejmech.2020.112891
   PIZZINO G, 2017, OXID MED CELL LONGEV, V2017, DOI DOI 10.1155/2017/8416763
   Pompella A, 2003, BIOCHEM PHARMACOL, V66, P1499, DOI 10.1016/S0006-2952(03)00504-5
   Radi R, 2018, P NATL ACAD SCI USA, V115, P5839, DOI 10.1073/pnas.1804932115
   Raza H, 2011, FEBS J, V278, P4243, DOI 10.1111/j.1742-4658.2011.08358.x
   Sabharwal SS, 2014, NAT REV CANCER, V14, P709, DOI 10.1038/nrc3803
   Sahiner UM, 2018, PEDIAT ALLERG IMM-UK, V29, P789, DOI 10.1111/pai.12965
   Sandalio Luisa M, 2013, Subcell Biochem, V69, P231, DOI 10.1007/978-94-007-6889-5_13
   Schallreuter KU, 2007, BIOCHEM BIOPH RES CO, V360, P70, DOI 10.1016/j.bbrc.2007.05.218
   Schneider Cláudia Dornelles, 2004, Rev Bras Med Esporte, V10, P308, DOI 10.1590/S1517-86922004000400008
   Schrader M, 2006, BBA-MOL CELL RES, V1763, P1755, DOI 10.1016/j.bbamcr.2006.09.006
   Selvam MKP, 2022, ADV EXP MED BIOL, V1358, P63, DOI 10.1007/978-3-030-89340-8_4
   Sharifi-Rad M, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.00694
   Shnayder NA, 2021, MOLECULES, V26, DOI 10.3390/molecules26092431
   Singh A, 2019, MOLECULES, V24, DOI 10.3390/molecules24081583
   SLATER TF, 1984, BIOCHEM J, V222, P1
   Taysi S, 2022, MINI-REV MED CHEM, V22, P1847, DOI 10.2174/1389557522666220104151225
   Taysi S, 2019, MINI-REV MED CHEM, V19, P178, DOI 10.2174/1389557518666181015151350
   Thomas DD, 2008, FREE RADICAL BIO MED, V45, P18, DOI 10.1016/j.freeradbiomed.2008.03.020
   Underbakke E.S., 2013, COMPREHENSIVE INORGA, P241
   Villamena FA, 2013, MOLECULAR BASIS OF OXIDATIVE STRESS: CHEMISTRY, MECHANISMS, AND DISEASE PATHOGENESIS, P1
   Vona R, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8267234
   Xue QJ, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19123805
   Zargari F, 2022, J XENOBIOTICS, V12, P214, DOI 10.3390/jox12030016
   Zeeshan HMA, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17030327
   Zhou YW, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.650214
   Zhu H, 2013, MOLECULAR BASIS OF OXIDATIVE STRESS: CHEMISTRY, MECHANISMS, AND DISEASE PATHOGENESIS, P113
NR 96
TC 61
Z9 64
U1 27
U2 73
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 2567-9430
EI 2567-9449
J9 J LAB MED
JI J. Lab. Med.
PD FEB 23
PY 2023
VL 47
IS 1
BP 1
EP 11
DI 10.1515/labmed-2022-0108
PG 11
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA S2DH9
UT WOS:001069321700001
OA gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Reddy, MTK
   Kolalapudi, SA
   Praveen, S
   Konala, S
   Rasajna, GL
   Khutate, SS
AF Reddy, M. Thanoj K.
   Kolalapudi, Seetharam A.
   Praveen, Seva
   Konala, Subhashini
   Rasajna, Gunnam L.
   Khutate, Saloni S.
TI Clinical and Laboratory Parameters of Metabolic Syndrome in Chronic
   Spontaneous Urticaria: A Cross-Sectional Study
SO INDIAN DERMATOLOGY ONLINE JOURNAL
LA English
DT Article
DE Chronic spontaneous urticaria; metabolic syndrome; oxidative stress
AB Background: Chronic spontaneous urticaria (CSU) appears to share some pathomechanisms with metabolic syndrome (MS), such as proinflammatory state, increased oxidative stress, changes in adipokine profile, and coagulation system activation. Aim and Objectives: To evaluate clinical and laboratory parameters of MS in CSU patients and to assess relationship of MS with duration and severity of CSU, Ig-E, thyroid-stimulating hormone (TSH), C-reactive protein (CRP), and autologous serum skin test (ASST). Materials and Methods: A hospital-based cross-sectional study was conducted on 131 CSU cases and 131 controls who were age- and sex-matched. Duration of the CSU and urticaria activity score (UAS) were noted. Waist circumference (WC), blood pressure, fasting blood sugar, high-density lipoprotein (HDL), triglycerides (TG), CRP, TSH, IgE, and ASST were noted. MS was considered according to Harmonization Asian criteria. Results: The percentage of patients with elevated clinical and laboratory parameters of MS was higher in cases compared to controls, in which WC, HDL, and TG were significantly elevated. MS was positive in 25.19% and 14.50% of cases and controls, respectively (P = 0.044). Cases with MS had a significant higher mean duration (16.60 months) than those without MS (8.81 months) (P = 0.004). MS was positive in 15.2%, 32.3%, and 36.4% of mild, moderate, and severe UAS patients, respectively (P = 0.095). Patients with increased TSH and CRP had a significantly higher percentage of MS (68.4% and 40.7%, respectively) than with normal TSH and CRP (15% and 19.4%, respectively) (P < 0.05), while it was not significant with respect to IgE and ASST. Limitations: Small sample size and it was a hospital-based study, therefore, all controls were from the patients attending our outpatient department only and could not be compared with the general population. Conclusion: MS is not uncommon in CSU patients. The duration of CSU, CRP levels, and TSH levels have a significant positive correlation with MS. Screening, along with regular surveillance of CSU patients, aids in the early detection of MS and minimizes the risk of cardiovascular disease.
C1 [Reddy, M. Thanoj K.; Kolalapudi, Seetharam A.; Praveen, Seva; Konala, Subhashini; Rasajna, Gunnam L.; Khutate, Saloni S.] GSL Med Coll & Gen Hosp, Dept Dermatol Venereol & Leprosy, Rajahmahendravaram 533296, Andhra Pradesh, India.
RP Konala, S (corresponding author), GSL Med Coll & Gen Hosp, Dept Dermatol Venereol & Leprosy, Rajahmahendravaram 533296, Andhra Pradesh, India.
EM subha.konala@gmail.com
FU IADVL postgraduate thesis research grant
FX Our study was supported by IADVL postgraduate thesis research grant.
CR Adusumilli NC, 2021, J DRUGS DERMATOL, V20, P354, DOI [10.36849/JDD.0421, 10.36849/JDD.2021.NVRM0421]
   Akça HM, 2017, TURK DERMATOL DERG, V11, P17, DOI 10.4274/tdd.3118
   Bhor Urmila, 2006, Indian J Dermatol Venereol Leprol, V72, P315
   Bracken SJ, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.00627
   Choudhary D., 2020, Birat J Health Sci, V5, P1087, DOI [10.3126/bjhs.v5i2.31411, DOI 10.3126/BJHS.V5I2.31411]
   Gupta P, 2023, ARCH DERMATOL RES, V315, P2445, DOI 10.1007/s00403-023-02636-z
   Harikrishnan S, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0192372
   Kessel A, 2010, INT ARCH ALLERGY IMM, V153, P288, DOI 10.1159/000314370
   Mandel V. D., 2020, European Medical Journal, V5, P29
   Park BW, 2019, DERMATOL SIN, V37, P67, DOI 10.4103/ds.ds_13_18
   Plavsic A, 2021, POSTEP DERM ALERGOL, V38, P1017, DOI 10.5114/ada.2021.112276
   Sawant A, 2011, CHOLESTEROL, DOI 10.1155/2011/920983
   Shalom G, 2018, J EUR ACAD DERMATOL, V32, P276, DOI 10.1111/jdv.14548
   Vena GA, 2017, EUR ANN ALLERGY CLIN, V49, P208, DOI 10.23822/EurAnnACI.1764-1489.12
   Ye YM, 2013, ACTA DERM-VENEREOL, V93, P156, DOI 10.2340/00015555-1443
NR 15
TC 0
Z9 0
U1 0
U2 0
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 2229-5178
EI 2249-5673
J9 INDIAN DERMATOL ONL
JI Indian Dermatol. Online J.
PD JAN-FEB
PY 2025
VL 16
IS 1
BP 105
EP 109
DI 10.4103/idoj.idoj_945_24
PG 5
WC Dermatology
WE Emerging Sources Citation Index (ESCI)
SC Dermatology
GA Q5C0R
UT WOS:001384847100025
PM 39850703
OA gold
DA 2025-06-11
ER

PT J
AU Zheng, NN
   Ding, XD
   Wei, D
   Dai, B
   Zheng, LY
   Sumi, R
   Hu, DH
   Jahane, R
   Sun, LN
AF Zheng, Ningning
   Ding, Xudong
   Wei, Dan
   Dai, Bo
   Zheng, Lanyan
   Sumi, Ryo
   Hu, Dahai
   Jahane, Rabita
   Sun, Luning
TI Therapeutic Effects of Coccomyxagloeobotrydiformis on the Metabolic
   Syndrome in Rats
SO CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Metabolic Syndrome; Cardiovascular Disease; Mitochondrial Respiratory
   Chain; Oxidative Stress
ID COCCOMYXA GLOEOBOTRYDIFORMIS; INSULIN-RESISTANCE; TROPOMODULIN1;
   EXPRESSION; LEIOMODIN; FILAMENTS; PATHWAY; HEART; END
AB Background/Aims: The metabolic syndrome (MS) is a cluster of metabolic changes that carry a high risk of cardiovascular disease (CVD). A newly discovered microalga, coccomyxagloeobotrydiformis (CGD), has been reported to improve ischemic stroke and metabolism-related indicators. We observed the therapeutic effects of CGD on MS and postulated the underlying mechanism. Methods: A diet-induced MS model in rats was used to observe the therapeutic effects of CGD on MS. Blood-glucose and lipid indices were measured using enzymatic colorimetric kits. A biologic data acquisition and analysis system (BL-420F) was used to evaluate cardiac function. Expression of mitochondrial respiratory chain (MRC) enzymes was measured by immunofluorescence staining. The proteins associated with oxidative stress, apoptosis and inflammation were detected by western blotting. Results: Body weight, abdominal circumference, fasting blood glucose, blood pressure as well as serum levels of total cholesterol, triglycerides and low-density lipoprotein-cholesterol were decreased whereas serum levels of high-density lipoprotein-cholesterol was increased in CGD-treated MS rats. CGD increased left-ventricular systolic pressure, left-ventricular end-diastolic pressure, left-ventricular systolic pressure maximum rate of increase and left-ventricular diastolic pressure maximum rate of decrease in MS rats with cardiovascular complications. CGD up-regulated expression of adenosine monophosphate-activated protein kinase and peroxisome proliferator activated receptor gamma coactivator 1-alpha in the heart, adipose tissue and skeletal muscle. Expression of the MRC subunits of ATPase 6, cytochrome b and succinate dehydrogenase complex, subunit-A was increased whereas that of uncoupling protein-2 decreased in different tissues. CGD showed anti-oxidation effects by increasing expression of superoxide dismutase and decreasing that of malondialdehyde. High expression of Bcl-2 and low expression of Bax and caspase-3 supported the anti-apoptotic effect of CGD on the cardiovascular complications of MS. Conclusion: CGD has a therapeutic effect on MS and associated cardiovascular complications by eliciting mitochondrial protection and having anti-oxidation and anti-apoptosis effects. CGD could be used for MS treatment. (c) 2018 The Author(s) Published by S. Karger AG, Basel
C1 [Zheng, Ningning; Sun, Luning] China Med Univ, Coll Basic Med Sci, Dept Pathophysiol, Shenyang, Liaoning, Peoples R China.
   [Ding, Xudong] China Med Univ, Shengjing Hosp, Dept Anesthesiol, Shenyang, Liaoning, Peoples R China.
   [Wei, Dan; Dai, Bo] China Med Univ, Grad Sch, Dept Pathophysiol, Shenyang, Liaoning, Peoples R China.
   [Zheng, Lanyan] China Med Univ, Coll Basic Med Sci, Dept Pathogen Biol, Shenyang, Liaoning, Peoples R China.
   [Sumi, Ryo] Nikken Sohonsha Corp Japan, Tanaka Mem Lab, Gifu, Japan.
   [Hu, Dahai] Univ Sci & Technol China, Sch Management, Dept Stat & Finance, Hefei, Anhui, Peoples R China.
   [Jahane, Rabita] China Med Univ, Int Educ Sch, Shenyang, Liaoning, Peoples R China.
C3 China Medical University; China Medical University; China Medical
   University; China Medical University; Chinese Academy of Sciences;
   University of Science & Technology of China, CAS; China Medical
   University
RP Sun, LN (corresponding author), Coll Basic Med Sci, Dept Pathophysiol, 77 Puhe Rd, Shenyang 110122, Liaoning, Peoples R China.
EM lnsun@cmu.edu.cn
RI Zheng, Ningning/KHU-0389-2024; yang, xuekang/IUP-2564-2023
FU Nikken Sohonsha Corporation of Japan (FDN) [201701]
FX This research was funded by Nikken Sohonsha Corporation of Japan
   (FDN#201701).
CR Aral C, 2011, HORM-INT J ENDOCRINO, V10, P298, DOI 10.14310/horm.2002.1321
   Arany Z, 2008, P NATL ACAD SCI USA, V105, P4721, DOI 10.1073/pnas.0800979105
   Cenik BK, 2015, J CLIN INVEST, V125, P1569, DOI 10.1172/JCI80115
   Chandra D, 2005, J BIOL CHEM, V280, P19051, DOI 10.1074/jbc.M501391200
   Chereau D, 2008, SCIENCE, V320, P239, DOI 10.1126/science.1155313
   Chu X, 2003, AM J PHYSIOL-HEART C, V284, pH1827, DOI 10.1152/ajpheart.00947.2002
   Dimroth P, 2000, J EXP BIOL, V203, P51
   Dugan LL, 2013, J CLIN INVEST, V123, P4888, DOI 10.1172/JCI66218
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Fritz-Six KL, 2003, J CELL BIOL, V163, P1033, DOI 10.1083/jcb.200308164
   Fuster V, 2012, MT SINAI J MED, V79, P625, DOI 10.1002/msj.21344
   Green DR, 2004, SCIENCE, V305, P626, DOI 10.1126/science.1099320
   Grundy SM, 2012, J AM COLL CARDIOL, V59, P635, DOI 10.1016/j.jacc.2011.08.080
   HAFFNER SM, 1992, DIABETES, V41, P715, DOI 10.2337/diabetes.41.6.715
   HOCKENBERY DM, 1993, CELL, V75, P241, DOI 10.1016/0092-8674(93)80066-N
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Ishida Y, 2012, J AGR FOOD CHEM, V60, P4222, DOI 10.1021/jf2048542
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Juo SHH, 2010, MITOCHONDRION, V10, P294, DOI 10.1016/j.mito.2010.01.001
   Kerner J, 2000, BBA-MOL CELL BIOL L, V1486, P1, DOI 10.1016/S1388-1981(00)00044-5
   Kim Y, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/3165396
   Krauss S, 2005, NAT REV MOL CELL BIO, V6, P248, DOI 10.1038/nrm1592
   Kumari M, 2018, SEMIN IMMUNOPATHOL, V40, P189, DOI 10.1007/s00281-017-0668-3
   Lee-Young RS, 2011, INT J OBESITY, V35, P982, DOI 10.1038/ijo.2010.220
   Ly T, 2016, MOL BIOL CELL, V27, P2565, DOI 10.1091/mbc.E16-03-0200
   Ma WJ, 2015, AM J CLIN NUTR, V101, P153, DOI 10.3945/ajcn.114.092601
   Mandavia CH, 2012, METABOLISM, V61, P1205, DOI 10.1016/j.metabol.2012.02.013
   McKeown CR, 2008, CIRC RES, V103, P1241, DOI 10.1161/CIRCRESAHA.108.178749
   Mozaffarian D, 2015, CIRCULATION, V131, pE29, DOI 10.1161/CIR.0000000000000152
   Nguemeni C, 2010, PHARMACOL RES, V61, P226, DOI 10.1016/j.phrs.2009.12.007
   Nibbs RJB, 2013, NAT REV IMMUNOL, V13, P815, DOI 10.1038/nri3544
   Palmieri VO, 2011, NUTRITION, V27, P773, DOI 10.1016/j.nut.2010.08.016
   Perry RJ, 2016, NATURE, V534, P213, DOI 10.1038/nature18309
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Sun F, 2005, CELL, V121, P1043, DOI 10.1016/j.cell.2005.05.025
   Sun LN, 2015, INT J BIOL SCI, V11, P825, DOI 10.7150/ijbs.10861
   Sun LN, 2013, INT J BIOL SCI, V9, P811, DOI 10.7150/ijbs.6734
   Tian WL, 2015, FEBS LETT, V589, P1847, DOI 10.1016/j.febslet.2015.05.020
   Tsukada T, 2010, J CELL SCI, V123, P3136, DOI 10.1242/jcs.071837
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Yan WJ, 2013, BASIC RES CARDIOL, V108, DOI 10.1007/s00395-013-0329-1
   Yuan JY, 2006, MOL CELL, V23, P1, DOI 10.1016/j.molcel.2006.06.008
   Yuen M, 2014, J CLIN INVEST, V124, P4693, DOI 10.1172/JCI75199
   Zhang ZL, 1998, NATURE, V392, P677, DOI 10.1038/33612
   Zheng NN, 2015, CELL PHYSIOL BIOCHEM, V36, P1903, DOI 10.1159/000430159
NR 46
TC 5
Z9 5
U1 1
U2 10
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1015-8987
EI 1421-9778
J9 CELL PHYSIOL BIOCHEM
JI Cell. Physiol. Biochem.
PY 2018
VL 48
IS 4
BP 1519
EP 1529
DI 10.1159/000492262
PG 11
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA GS4LR
UT WOS:000443615100010
PM 30071531
OA gold
DA 2025-06-11
ER

PT J
AU Lee, SY
   Chen, SL
   Chang, YH
   Chen, PS
   Huang, SY
   Tzeng, NS
   Wang, CL
   Wang, LJ
   Lee, IH
   Wang, TY
   Chen, KC
   Yang, YK
   Hong, JS
   Lu, RB
AF Lee, S. -Y.
   Chen, S. -L.
   Chang, Y. -H.
   Chen, P. -S.
   Huang, S. -Y.
   Tzeng, N. -S.
   Wang, C. -L.
   Wang, L. -J.
   Lee, I. -H.
   Wang, T. -Y.
   Chen, K. -C.
   Yang, Y. -K.
   Hong, J. -S.
   Lu, R. -B.
TI Correlation of plasma brain-derived neurotrophic factor and metabolic
   profiles in drug-naive patients with bipolar II disorder after a
   twelve-week pharmacological intervention
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE bipolar II disorder; body mass index; metabolic syndrome; brain-derived
   neurotrophic factor
ID FACTOR BDNF; DEPRESSED-PATIENTS; HUMAN PLATELETS; MOOD EPISODES; SERUM;
   LITHIUM; NGF; RESTRICTION; PLASTICITY; GENDER
AB ObjectiveBrain-derived neurotrophic factor (BDNF) is thought to be involved in the pathophysiology of bipolar disorder (BD) and metabolic syndrome. We investigated the correlation between plasma BDNF with mood symptoms and metabolic indices in patients with BD-II over a 12-week pharmacological intervention.
   MethodDrug-naive patients with BD-II (n=117) were recruited. Metabolic profiles [cholesterol, triglyceride, HbA1C, fasting serum glucose, body mass index (BMI)] and plasma BDNF wtrun "tblautotrun "tblsctrun "tbl_contere measured at baseline and 2, 8, and 12weeks after beginning medication. To adjust within-subject dependence over repeated assessments, multiple linear regressions with generalized estimating equation methods were used.
   ResultsSeventy-six (65.0%) patients completed the intervention. Plasma BDNF levels were significantly associated with BMI (P=9.6E-5), low-density lipoprotein (P=0.034) and total (P=0.001) cholesterol, but not with the Hamilton Depression Rating Scale-17 and Young Mania Rating Scale scores over the 12-week treatment.
   ConclusionWe found initial evidence of a positive correlation between plasma BDNF levels and BMI, low-density lipoprotein and total cholesterol in drug-naive patients with BD-II. The specific function of BDNF in regulating and maintaining peripheral metabolic health requires additional investigation.
C1 [Lee, S. -Y.] Kaohsiung Vet Gen Hosp, Dept Psychiat, Kaohsiung, Taiwan.
   [Lee, S. -Y.; Chen, S. -L.; Chang, Y. -H.; Chen, P. -S.; Wang, C. -L.; Lee, I. -H.; Chen, K. -C.; Yang, Y. -K.; Lu, R. -B.] Natl Cheng Kung Univ, Dept Psychiat, Coll Med, Tainan 70428, Taiwan.
   [Chen, S. -L.; Lu, R. -B.] Kaohsiung Med Univ, Sch Med, Dept Neurol, Kaohsiung, Taiwan.
   [Chang, Y. -H.] Natl Cheng Kung Univ, Inst Allied Hlth Sci, Coll Med & Hosp, Tainan 70428, Taiwan.
   [Huang, S. -Y.; Tzeng, N. -S.] Triserv Gen Hosp, Natl Def Med Ctr, Dept Psychiat, Taipei, Taiwan.
   [Wang, L. -J.] Kaohsiung Chang Gung Mem Hosp, Dept Child & Adolescent Psychiat, Kaohsiung, Taiwan.
   [Wang, L. -J.] Chang Gung Univ, Coll Med, Kaohsiung, Taiwan.
   [Wang, T. -Y.] Tainan Hosp, Dept Hlth, Dept Psychiat, Tainan, Taiwan.
   [Chen, K. -C.; Lu, R. -B.] Natl Cheng Kung Univ Hosp, Dept Psychiat, Yunlin, Taiwan.
   [Yang, Y. -K.] Natl Cheng Kung Univ, Addict Res Ctr, Tainan 70428, Taiwan.
   [Hong, J. -S.] NIEHS, Lab Toxicol & Pharmacol, NIH, Res Triangle Pk, NC 27709 USA.
   [Lu, R. -B.] Inst Behav Med, Tainan, Taiwan.
   [Lu, R. -B.] Natl Hlth Res Inst, Ctr Neuropsychiat Res, Miaoli, Taiwan.
C3 Kaohsiung Veterans General Hospital; National Cheng Kung University;
   Kaohsiung Medical University; National Cheng Kung University; National
   Defense Medical Center; Tri-Service General Hospital; Chang Gung
   Memorial Hospital; Chang Gung University; National Cheng Kung
   University; National Cheng Kung University Hospital; National Cheng Kung
   University; National Institutes of Health (NIH) - USA; NIH National
   Institute of Environmental Health Sciences (NIEHS); National Health
   Research Institutes - Taiwan
RP Lu, RB (corresponding author), Natl Cheng Kung Univ, Inst Behav Med, Dept Psychiat, Addict Ctr,Coll Med & Hosp, 138 Sheng Li Rd, Tainan 70428, Taiwan.
EM rblu@mail.ncku.edu.tw
RI Chen, Chih-Ping/D-1416-2014; Chen, Shiou/AEV-7272-2022; Wang,
   Liang-Jen/AAR-1089-2020; Chen, Po/AAA-6492-2021; Tzeng,
   Nian-Sheng/AAU-4945-2021; Hong, Jau-Shyong/F-1920-2019
OI Hong, Jau-Shyong/0000-0002-3056-8401; Chang,
   Yun-Hsuan/0000-0001-8662-2457
FU Taiwan National Science Council [NSC98-2314-B-006-022-MY3,
   NSC100-2314-B-075B-010-MY3]; Taiwan Department of Health [DOH
   95-TD-M-113-055]; Taiwan National Health Research Institute
   [NHRI-EX-97-9738NI]; National Cheng Kung University Project for
   Promoting Academic Excellence and Developing World Class Research
   Centers
FX This work was supported in part by grant NSC98-2314-B-006-022-MY3 (to
   RBL) and NSC100-2314-B-075B-010-MY3 (to SYL) from the Taiwan National
   Science Council, grant DOH 95-TD-M-113-055 (to RBL) from the Taiwan
   Department of Health, grant NHRI-EX-97-9738NI (to RBL) from the Taiwan
   National Health Research Institute, and the National Cheng Kung
   University Project for Promoting Academic Excellence and Developing
   World Class Research Centers.
CR Akiskal H, 2007, ACTA PSYCHIAT SCAND, V116, P395, DOI 10.1111/j.1600-0447.2007.01115.x
   Angst J, 2012, EUR ARCH PSY CLIN N, V262, P3, DOI 10.1007/s00406-011-0228-0
   Angst J, 2007, BRIT J PSYCHIAT, V190, P189, DOI 10.1192/bjp.bp.106.030957
   Angst J, 2011, ARCH GEN PSYCHIAT, V68, P791, DOI 10.1001/archgenpsychiatry.2011.87
   [Anonymous], 1996, G POWER PRIORI POST
   Araya AV, 2008, ENDOCRINE, V33, P300, DOI 10.1007/s12020-008-9090-x
   Barbosa IG, 2013, REV BRAS PSIQUIATR, V35, P67, DOI 10.1016/j.rbp.2012.05.011
   Barbosa IG, 2012, J AFFECT DISORDERS, V137, P151, DOI 10.1016/j.jad.2011.12.034
   Barbosa IG, 2010, NEUROSCI LETT, V475, P95, DOI 10.1016/j.neulet.2010.03.055
   Benazzi F, 2003, J AFFECT DISORDERS, V73, P33, DOI 10.1016/S0165-0327(02)00327-0
   Beumer W, 2012, PSYCHONEUROENDOCRINO, V37, P1901, DOI 10.1016/j.psyneuen.2012.04.001
   Bocchio-Chiavetto L, 2006, EUR NEUROPSYCHOPHARM, V16, P620, DOI 10.1016/j.euroneuro.2006.04.010
   Bulló M, 2007, EUR J ENDOCRINOL, V157, P303, DOI 10.1530/EJE-06-0716
   Bus BAA, 2011, PSYCHONEUROENDOCRINO, V36, P228, DOI 10.1016/j.psyneuen.2010.07.013
   Chaldakov GN, 2004, PROG BRAIN RES, V146, P279, DOI 10.1016/S0079-6123(03)46018-4
   Cirulli F, 2009, PSYCHONEUROENDOCRINO, V34, P172, DOI 10.1016/j.psyneuen.2008.08.020
   Corripio R, 2012, CLIN ENDOCRINOL, V77, P715, DOI 10.1111/j.1365-2265.2012.04431.x
   Cotman CW, 2002, TRENDS NEUROSCI, V25, P295, DOI 10.1016/S0166-2236(02)02143-4
   Pellegrinelli KD, 2013, ACTA PSYCHIAT SCAND, V127, P153, DOI 10.1111/acps.12007
   de Oliveira GS, 2009, J PSYCHIATR RES, V43, P1171, DOI 10.1016/j.jpsychires.2009.04.002
   Drancourt N, 2013, ACTA PSYCHIAT SCAND, V127, P136, DOI 10.1111/j.1600-0447.2012.01917.x
   Duman RS, 2002, MOL PSYCHIATR, V7, pS29, DOI 10.1038/sj.mp.4001016
   ENDICOTT J, 1978, ARCH GEN PSYCHIAT, V35, P837
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   Faul F, 2009, BEHAV RES METHODS, V41, P1149, DOI 10.3758/BRM.41.4.1149
   Fernandes BS, 2011, J PSYCHIATR RES, V45, P995, DOI 10.1016/j.jpsychires.2011.03.002
   Fernandes BS, 2009, J PSYCHIATR RES, V43, P1200, DOI 10.1016/j.jpsychires.2009.04.010
   Ghaemi SN, 2000, COMPR PSYCHIAT, V41, P167, DOI 10.1016/S0010-440X(00)90043-9
   Goldberg JF, 2009, AM J PSYCHIAT, V166, P173, DOI 10.1176/appi.ajp.2008.08050746
   Golden E, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010099
   Grande I, 2014, ACTA PSYCHIAT SCAND, V129, P393, DOI 10.1111/acps.12192
   Grande I, 2012, J PSYCHIATR RES, V46, P1511, DOI 10.1016/j.jpsychires.2012.08.017
   HAMILTON M, 1967, Br J Soc Clin Psychol, V6, P278
   Huang SY, 2004, ALCOHOL CLIN EXP RES, V28, P374, DOI 10.1097/01.ALC.0000117832.62901.61
   Judd LL, 2003, J AFFECT DISORDERS, V73, P19, DOI 10.1016/S0165-0327(02)00324-5
   Karege F, 2005, BIOL PSYCHIAT, V57, P1068, DOI 10.1016/j.biopsych.2005.01.008
   Kerschensteiner M, 1999, J EXP MED, V189, P865, DOI 10.1084/jem.189.5.865
   Krabbe KS, 2007, DIABETOLOGIA, V50, P431, DOI 10.1007/s00125-006-0537-4
   Krabbe KS, 2009, J AM GERIATR SOC, V57, P1447, DOI 10.1111/j.1532-5415.2009.02345.x
   Laske C, 2006, THROMB HAEMOSTASIS, V96, P102
   Lim CS, 2013, NEUROSCI BIOBEHAV R, V37, P418, DOI 10.1016/j.neubiorev.2013.01.003
   Lin PY, 2009, NEUROSCI LETT, V466, P139, DOI 10.1016/j.neulet.2009.09.044
   Lommatzsch M, 2005, AM J RESP CRIT CARE, V171, P115, DOI 10.1164/rccm.200406-758OC
   Lommatzsch M, 2005, NEUROBIOL AGING, V26, P115, DOI 10.1016/j.neurobiolaging.2004.03.002
   Lyons WE, 1999, P NATL ACAD SCI USA, V96, P15239, DOI 10.1073/pnas.96.26.15239
   Machado-Vieira R, 2007, BIOL PSYCHIAT, V61, P142, DOI 10.1016/j.biopsych.2006.03.070
   Malhi GS, 2013, CNS DRUGS, V27, P135, DOI 10.1007/s40263-013-0039-0
   Manni L, 2005, INT J CARDIOL, V102, P169, DOI 10.1016/j.ijcard.2004.10.041
   Martin B, 2007, ENDOCRINOLOGY, V148, P4318, DOI 10.1210/en.2007-0161
   Matthews VB, 2009, DIABETOLOGIA, V52, P1409, DOI 10.1007/s00125-009-1364-1
   Merhi ZO, 2009, FERTIL STERIL, V91, P1544, DOI 10.1016/j.fertnstert.2008.09.032
   Pan WH, 1998, NEUROPHARMACOLOGY, V37, P1553, DOI 10.1016/S0028-3908(98)00141-5
   Pillai A, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039358
   Pillai A, 2010, INT J NEUROPSYCHOPH, V13, P535, DOI 10.1017/S1461145709991015
   Radka SF, 1996, BRAIN RES, V709, P122, DOI 10.1016/0006-8993(95)01321-0
   Ricken R, 2013, J CLIN PSYCHOPHARM, V33, P806, DOI 10.1097/JCP.0b013e3182a412b8
   Schwarz E, 2008, EXPERT REV MOL DIAGN, V8, P209, DOI 10.1586/14737159.8.2.209
   Sen S, 2008, BIOL PSYCHIAT, V64, P527, DOI 10.1016/j.biopsych.2008.05.005
   Shen CW, 2012, BIOMETRICS, V68, P1046, DOI 10.1111/j.1541-0420.2012.01758.x
   Shimizu E, 2003, BIOL PSYCHIAT, V54, P70, DOI 10.1016/S0006-3223(03)00181-1
   Soeiro-de-Souza MG, 2012, ACTA PSYCHIAT SCAND, V126, P332, DOI 10.1111/j.1600-0447.2012.01889.x
   Suwalska A, 2010, NEUROPSYCHOBIOLOGY, V62, P229, DOI 10.1159/000319949
   Taylor V, 2006, J CLIN PSYCHIAT, V67, P1034, DOI 10.4088/JCP.v67n0704
   Vieta E, 2008, BIPOLAR DISORD, V10, P163, DOI 10.1111/j.1399-5618.2007.00561.x
   YAMAMOTO H, 1990, J NEUROSCI, V10, P3469
   YOUNG RC, 1978, BRIT J PSYCHIAT, V133, P429, DOI 10.1192/bjp.133.5.429
   ZEGER SL, 1988, BIOMETRICS, V44, P1049, DOI 10.2307/2531734
NR 67
TC 13
Z9 13
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
EI 1600-0447
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD FEB
PY 2015
VL 131
IS 2
BP 120
EP 128
DI 10.1111/acps.12324
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AY1SS
UT WOS:000347372900005
PM 25131388
OA Bronze
DA 2025-06-11
ER

PT J
AU Trovato, E
   Rubegni, P
   Prignano, F
AF Trovato, Emanuele
   Rubegni, Pietro
   Prignano, Francesca
TI Place in therapy of anti-IL-17 and 23 in psoriasis according to the
   severity of comorbidities: a focus on cardiovascular disease and
   metabolic syndrome
SO EXPERT OPINION ON BIOLOGICAL THERAPY
LA English
DT Article
DE Psoriasis; biologics; cardiovascular disease; obesity; atherosclerosis
ID VASCULAR INFLAMMATION; ATHEROSCLEROSIS; INTERLEUKIN-17A; MODERATE;
   OUTCOMES; RISK
AB Introduction Psoriasis is an inflammatory disease nowadays considered not only as a cutaneous but as a systemic disease. Among the numerous comorbidities, psoriatic arthritis (PsA), depression, obesity, and cardiovascular disease (CVD) are considered the most frequent. In addition, metabolic syndrome (MetS), which involves hypertension, dyslipidemia, obesity, and atherosclerosis, has presented a higher prevalence in recent years, especially in psoriatic patients. Areas covered The mechanism linking anti-tumor necrosis factor (TNF) to MetS and CVD has been widely explained, while there are unknowns about inhibitors of interleukin (IL)-17 and -23. Considering the growing incidence of CVD in the world's population and in particular the strict correlation in patients with psoriasis, it is important to identify therapeutic options able to avoid a negative impact on patients with both conditions. The aim of this paper is to perform a review of the scientific literature with a focus on the pathogenetic mechanism linking psoriasis to CVD and MetS. Expert opinion The scientific evidence currently available allows us to consider and support the use of anti-IL-17 and anti-IL-23 as a first-line therapy choice in psoriatic patients with high risk of CVDs or MetS.
C1 [Trovato, Emanuele; Rubegni, Pietro] Univ Siena, Dept Med Surg & Neurol Sci, Unit Dermatol, Siena, Italy.
   [Prignano, Francesca] Univ Florence, Dept Hlth Sci, Dermatol Sect, Florence, Italy.
C3 University of Siena; University of Florence
RP Trovato, E (corresponding author), Univ Siena, Dept Med Surg & Neurol Sci, Unit Dermatol, Siena, Italy.
EM trovato.ema@gmail.com
OI Trovato, Emanuele/0000-0001-8301-9206
CR Abbas A, 2015, STROKE, V46, P793, DOI 10.1161/STROKEAHA.114.006516
   Akhavanpoor M, 2017, CURR DRUG TARGETS, V18, P863, DOI 10.2174/1389450117666161229142155
   Amin M, 2018, AM J CLIN DERMATOL, V19, P1, DOI 10.1007/s40257-017-0328-3
   Armstrong A, 2020, DERMATOLOGY THER, V10, P133, DOI 10.1007/s13555-019-00340-3
   Augustin M, 2022, BRIT J DERMATOL, V186, P942, DOI 10.1111/bjd.20971
   Bettelli E, 2006, NATURE, V441, P235, DOI 10.1038/nature04753
   Booth A, 2016, HORM MOL BIOL CLIN I, V26, P25, DOI 10.1515/hmbci-2015-0073
   Borroni RG, 2021, ACTA DERM-VENEREOL, V101, DOI 10.2340/actadv.v101.283
   Burhans MS, 2019, COMPR PHYSIOL, V9, P1, DOI 10.1002/cphy.c170040
   Cao H, 2021, LIPIDS HEALTH DIS, V20, DOI 10.1186/s12944-021-01441-9
   Carneiro AB, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076233
   Chehimi M, 2017, J CLIN MED, V6, DOI 10.3390/jcm6070068
   Choi H, 2020, CIRC-CARDIOVASC IMAG, V13, DOI 10.1161/CIRCIMAGING.120.011199
   de Brito M, 2021, AM J CLIN DERMATOL, V22, P587, DOI 10.1007/s40257-021-00612-9
   Dowlatshahi EA, 2013, J INVEST DERMATOL, V133, P2347, DOI 10.1038/jid.2013.131
   Egeberg A, 2017, J AM ACAD DERMATOL, V77, P650, DOI 10.1016/j.jaad.2017.06.028
   Elnabawi YA, 2019, CARDIOVASC RES, V115, P721, DOI 10.1093/cvr/cvz009
   Fernández-Armenteros JM, 2019, J EUR ACAD DERMATOL, V33, P128, DOI 10.1111/jdv.15159
   Galluzzo M, 2022, EXPERT OPIN BIOL TH, V22, P367, DOI 10.1080/14712598.2022.1988566
   Gisondi P, 2022, ITAL J DERMATOL VENE, V157, P1, DOI 10.23736/S2784-8671.21.07132-2
   Gisondi P, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00117
   Gisondi P, 2015, FRONT MED-LAUSANNE, V2, DOI 10.3389/fmed.2015.00001
   Gyldenlove M, 2015, J AM ACAD DERMATOL, V72, P599, DOI 10.1016/j.jaad.2015.01.004
   Hansel K, 2021, J EUR ACAD DERMATOL, V35, pE169, DOI 10.1111/jdv.17003
   Inaba Y, 2010, INT J CARDIOVAS IMAG, V26, P631, DOI 10.1007/s10554-010-9616-1
   Jia Y, 2018, J DERMATOL SCI, V89, P112, DOI 10.1016/j.jdermsci.2017.11.006
   Kasikara C, 2018, J CLIN INVEST, V128, P2713, DOI 10.1172/JCI97950
   Liu-Wu Y, 1998, ATHEROSCLEROSIS, V137, P351, DOI 10.1016/S0021-9150(97)00295-5
   Madhur MS, 2011, ARTERIOSCL THROM VAS, V31, P1565, DOI 10.1161/ATVBAHA.111.227629
   Mazzoccoli G, 2010, INTERN EMERG MED, V5, P495, DOI 10.1007/s11739-010-0458-6
   Mehta NN, 2011, ARCH DERMATOL, V147, P1031, DOI 10.1001/archdermatol.2011.119
   Mehta NN, 2010, EUR HEART J, V31, P1000, DOI 10.1093/eurheartj/ehp567
   Naik HB, 2015, ARTERIOSCL THROM VAS, V35, P2667, DOI 10.1161/ATVBAHA.115.306460
   Nordlohne J, 2019, CYTOKINE, V122, DOI 10.1016/j.cyto.2017.06.016
   Pirro F, 2021, CLIN DRUG INVEST, V41, P917, DOI 10.1007/s40261-021-01080-z
   Ramonda R, 2014, JOINT BONE SPINE, V81, P421, DOI 10.1016/j.jbspin.2014.02.005
   Reich K, 2020, J AM ACAD DERMATOL, V82, P936, DOI 10.1016/j.jaad.2019.11.040
   Rigopoulos D, 2020, SKIN APPENDAGE DISOR, V6, P134, DOI 10.1159/000507298
   Simon T, 2013, EUR HEART J, V34, P570, DOI 10.1093/eurheartj/ehs263
   Smith E, 2010, CIRCULATION, V121, P1746, DOI 10.1161/CIRCULATIONAHA.109.924886
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Stanescu AMA, 2021, J PERS MED, V11, DOI 10.3390/jpm11040251
   Thatiparthi A, 2021, AM J CLIN DERMATOL, V22, P425, DOI 10.1007/s40257-021-00603-w
   von Stebut E, 2020, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.03096
   von Stebut E, 2019, J INVEST DERMATOL, V139, P1054, DOI 10.1016/j.jid.2018.10.042
   Wan MT, 2018, J AM ACAD DERMATOL, V78, P315, DOI 10.1016/j.jaad.2017.10.050
   Wu L, 2014, J EXP MED, V211, P1441, DOI 10.1084/jem.20132126
   Yong K, 2013, AM J HYPERTENS, V26, P159, DOI 10.1093/ajh/hps032
   Zhou Q, 2009, FREE RADICAL BIO MED, V47, P891, DOI 10.1016/j.freeradbiomed.2009.06.033
   Zwain A, 2021, EUR CARDIOL REV, V16, DOI 10.15420/ecr.2020.15.R2
NR 50
TC 20
Z9 20
U1 0
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1471-2598
EI 1744-7682
J9 EXPERT OPIN BIOL TH
JI Expert Opin. Biol. Ther.
PD DEC 2
PY 2022
VL 22
IS 12
SI SI
BP 1443
EP 1448
DI 10.1080/14712598.2022.2093106
EA JUN 2022
PG 6
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 7C5SA
UT WOS:000817237100001
PM 35726639
DA 2025-06-11
ER

PT J
AU Chae, JS
   Kim, OY
   Paik, JK
   Kang, R
   Seo, WJ
   Jeong, TS
   Sweeney, G
   Lee, SH
   Lee, JH
AF Chae, Jey Sook
   Kim, Oh Yoen
   Paik, Jean Kyung
   Kang, Ryungwoo
   Seo, Woo Ju
   Jeong, Tae-Sook
   Sweeney, Gary
   Lee, Sang-Hyun
   Lee, Jong Ho
TI Association of Lp-PLA2 activity and LDL size with
   interleukin-6, an inflammatory cytokine and oxidized LDL, a marker of
   oxidative stress, in women with metabolic syndrome
SO ATHEROSCLEROSIS
LA English
DT Article
DE Lp-PLA(2) activity; Interleukin-6; Oxidized LDL; LDL size; Metabolic
   syndrome; Women
ID ACTIVATING-FACTOR-ACETYLHYDROLASE; PHOSPHOLIPASE A(2) ACTIVITY;
   LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; RISK; ATHEROSCLEROSIS;
   EPIDEMIOLOGY
AB Objective: We investigated an association between lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) activity, inflammation, and oxidative stress in women with metabolic syndrome (MS).
   Methods: We performed a case-control study in MS women (n = 368) and non-MS women (n = 854). Lp-PLA(2) activity LDL particle size; leukocyte number; ox-LDL, LDL-cholesterol, TNF-alpha, IL-6, and CRP levels were measured.
   Results: MS women had smaller LDL particle size; higher plasma ox-LDL levels and Lp-PLA(2) activity; and higher serum TNF-alpha, IL-6, and CRP, than non-MS women. In controls, Lp-PLA(2) activity weakly but significantly correlated with LDL-cholesterol; in MS women, Lp-PLA(2) activity positively correlated with LDL-cholesterol, ox-LDL, TNF-alpha, and IL-6 after adjusting for age and BMI. The relationship between Lp-PLA(2) activity and ox-LDL still maintained after further adjustment for LDL-cholesterol. Additionally, Lp-PLA(2) activity together with LDL particle size were significant independent predictors of MS (multivariate analysis), and ox-LDL was a major contributor to the increase in Lp-PLA(2) activity in MS women (multiple stepwise regression). In a subgroup analysis, Lp-PLA(2) activity was negatively associated with IL-6 levels in non-MS postmenopausal women, but positively with IL-6 in both postmenopausal and premenopausal women with MS. Postmenopausal women with MS had significantly higher Lp-PLA(2) activity, ox-LDL and IL-6 than those without MS, and premenopausal women with or without MS, after the adjustment.
   Conclusions: Elevated plasma Lp-PLA(2) activity was associated with an increase in inflammatory cytokines, particularly IL-6 and ox-LDL in MS women. This association was also affected by menopause status, suggesting that Lp-PLA(2) may represent a novel marker for oxidation and inflammation in MS. Crown Copyright (C) 2011 Published by Elsevier Ireland Ltd. All rights reserved.
C1 [Lee, Jong Ho] Yonsei Univ, Dept Food & Nutr, Coll Human Ecol, Natl Res Lab Clin Nutrigenet Nutrigen, Seoul 120749, South Korea.
   [Chae, Jey Sook; Kim, Oh Yoen; Paik, Jean Kyung; Kang, Ryungwoo; Seo, Woo Ju; Lee, Jong Ho] Yonsei Univ, Res Inst Sci Aging, Seoul 120749, South Korea.
   [Kang, Ryungwoo; Lee, Jong Ho] Yonsei Univ, Coll Human, Brain Korea 21 Project, Dept Food & Nutr, Seoul 120749, South Korea.
   [Jeong, Tae-Sook] Korea Res Inst Biosci & Biotechnol, Natl Res Lab Lipid Metab & Atherosclerosis, Taejon, South Korea.
   [Sweeney, Gary] Inst Pasteur Korea, Seoul, South Korea.
   [Sweeney, Gary] York Univ, Dept Biol, Toronto, ON M3J 2R7, Canada.
   [Lee, Sang-Hyun] Natl Hlth Insurance Corp Ilsan Hosp, Dept Family Practice, Goyang Si, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University; Korea Research
   Institute of Bioscience & Biotechnology (KRIBB); Institut Pasteur Korea;
   York University - Canada
RP Lee, JH (corresponding author), Yonsei Univ, Dept Food & Nutr, Coll Human Ecol, Natl Res Lab Clin Nutrigenet Nutrigen, 134 Shinchon Ding, Seoul 120749, South Korea.
EM jhleeb@yonsei.ac.kr
RI Kim, Oh/AAA-6492-2022; Lee, Sang-Hyun/ABR-3363-2022
FU National Research Foundation, Ministry of Education, Science and
   Technology Republic of Korea [2010-0015017, 2010-0000317]
FX This work was supported by the National Research Foundation, Ministry of
   Education, Science and Technology (Mid-career Researcher Program:
   2010-0015017, and 2010-0000317) Republic of Korea.
CR Ahonen T, 2009, MEDIAT INFLAMM, V2009, DOI 10.1155/2009/959281
   Atik B, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011026
   Ballantyne CM, 2004, CIRCULATION, V109, P837, DOI 10.1161/01.CIR.0000116763.91992.F1
   Carlquist JF, 2007, EXPERT REV MOL DIAGN, V7, P511, DOI 10.1586/14737159.7.5.511
   De Keyzer D, 2009, ARTERIOSCL THROM VAS, V29, P2041, DOI 10.1161/ATVBAHA.109.196592
   Derbent A, 2011, GYNECOL ENDOCRINOL, V27, P128, DOI 10.3109/09513590.2010.487612
   Detopoulou P, 2009, LIPIDS HEALTH DIS, V8, DOI 10.1186/1476-511X-8-19
   Furberg CD, 2008, J AM GERIATR SOC, V56, P792, DOI 10.1111/j.1532-5415.2008.01667.x
   Gazi I, 2005, CLIN CHEM, V51, P2264, DOI 10.1373/clinchem.2005.058404
   Gazi I, 2006, METABOLISM, V55, P885, DOI 10.1016/j.metabol.2006.02.015
   Gong HP, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-13
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Iribarren C, 2005, ARTERIOSCL THROM VAS, V25, P216, DOI 10.1161/01.ATV.0000148322.89911.44
   Kim JY, 2008, AM J CLIN NUTR, V88, P630, DOI 10.1093/ajcn/88.3.630
   Koh KK, 2005, J AM COLL CARDIOL, V46, P1978, DOI 10.1016/j.jacc.2005.06.082
   Macphee CH, 1999, BIOCHEM J, V338, P479, DOI 10.1042/0264-6021:3380479
   Mohler ER, 2008, J AM COLL CARDIOL, V51, P1632, DOI 10.1016/j.jacc.2007.11.079
   Papanicolaou DA, 2000, J CLIN ENDOCR METAB, V85, P1331, DOI 10.1210/jc.85.3.1331
   Persson M, 2007, ARTERIOSCL THROM VAS, V27, P1411, DOI 10.1161/ATVBAHA.107.142679
   Persson M, 2007, ATHEROSCLEROSIS, V190, P388, DOI 10.1016/j.atherosclerosis.2006.02.016
   Rachon D, 2002, J ENDOCRINOL, V172, P387, DOI 10.1677/joe.0.1720387
   Rader DJ, 2000, NEW ENGL J MED, V343, P1179, DOI 10.1056/NEJM200010193431609
   Rizzo M, 2006, QJM-INT J MED, V99, P1, DOI 10.1093/qjmed/hci154
   Rizzo M, 2009, CLIN ENDOCRINOL, V70, P870, DOI 10.1111/j.1365-2265.2008.03407.x
   Shi Y, 2007, ATHEROSCLEROSIS, V191, P54, DOI 10.1016/j.atherosclerosis.2006.05.001
   Tsimihodimos V, 2002, J LIPID RES, V43, P256
   Wang WY, 2010, CARDIOVASC RES, V85, P845, DOI 10.1093/cvr/cvp367
   Wierzbicki AS, 2007, INT J CLIN PRACT, V61, P1779
   Zalewski A, 2005, ARTERIOSCL THROM VAS, V25, P923, DOI 10.1161/01.ATV.0000160551.21962.a7
NR 29
TC 25
Z9 25
U1 0
U2 9
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD OCT
PY 2011
VL 218
IS 2
BP 499
EP 506
DI 10.1016/j.atherosclerosis.2011.06.036
PG 8
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 836WJ
UT WOS:000296147600073
PM 21762913
DA 2025-06-11
ER

PT J
AU Wittbrodt, MT
   Moazzami, K
   Shah, AJ
   Lima, BB
   Hammadah, M
   Mehta, PK
   Quyyumi, AA
   Vaccarino, V
   Nye, JA
   Bremner, JD
AF Wittbrodt, Matthew T.
   Moazzami, Kasra
   Shah, Amit J.
   Lima, Bruno B.
   Hammadah, Muhammad
   Mehta, Puja K.
   Quyyumi, Arshed A.
   Vaccarino, Viola
   Nye, Jonathon A.
   Bremner, J. Douglas
TI Neural responses during acute mental stress are associated with angina
   pectoris
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Angina; Coronary artery disease; Mental stress; Frontal lobe;
   Cardiovascular
ID INDUCED MYOCARDIAL-ISCHEMIA; CHEST-PAIN; PSYCHOMETRIC PROPERTIES; HEALTH
   BEHAVIORS; SYNDROME-X; HEART; DISORDER; BRAIN; METAANALYSIS; STIMULATION
AB Angina pectoris is associated with increased risk of adverse cardiovascular events in coronary artery disease (CAD) patients, an effect not entirely attributable to the severity of CAD.
   Objective: Examine brain correlates of mental stress in patients with CAD with and without a history of angina.
   Methods: Participants (n = 170) with stable CAD completed the Seattle Angina Questionnaire along with other psychometric assessments. In this cross-sectional study, participants underwent laboratory-based mental stress testing using mental arithmetic and public speaking tasks along with control conditions in conjunction with positron emission tomography brain imaging using radiolabeled water. Brain activity during mental stress was compared between participants who did or did not report chest pain/angina in the previous month. A factor analysis was coupled with dominance analysis to identify brain regions associated with angina.
   Results: Participants reporting angina in the past month experienced greater (p<.005) activations within the left: frontal lobe (z = 4.01), temporal gyrus (z = 3.32), parahippocampal gyrus (z = 3.16), precentral gyrus (z = 3.14), right fusiform gyrus (z = 3.07), and bilateral cerebellum (z = 3.50) and deactivations within the right frontal gyrus (z = 3.67), left precuneus (z = 3.19), and left superior temporal gyrus (z = 3.11) during mental stress. A factor containing the left motor areas, inferior frontal lobe, and operculum (average McFadden's number addition = 0.057) in addition to depression severity (0.10) and adulthood trauma exposure (0.064) correlated with angina history.
   Conclusions: Self-reported angina in patients with stable CAD is associated with increased neural responses to stress in a network including the inferior frontal lobe, motor areas, and operculum, potentially indicating an upregulated pain perception response.
C1 [Wittbrodt, Matthew T.; Bremner, J. Douglas] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA.
   [Moazzami, Kasra; Shah, Amit J.; Lima, Bruno B.; Hammadah, Muhammad; Vaccarino, Viola] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA.
   [Moazzami, Kasra; Shah, Amit J.; Lima, Bruno B.; Hammadah, Muhammad; Mehta, Puja K.; Quyyumi, Arshed A.; Vaccarino, Viola] Emory Univ, Sch Med, Dept Med, Div Cardiol, Atlanta, GA USA.
   [Nye, Jonathon A.; Bremner, J. Douglas] Emory Univ, Sch Med, Dept Radiol, Atlanta, GA 30322 USA.
   [Shah, Amit J.; Bremner, J. Douglas] Atlanta VA Med Ctr, Decatur, GA USA.
C3 Emory University; Emory University; Rollins School Public Health; Emory
   University; Emory University; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); Atlanta VA Health Care System;
   Atlanta VA Medical Center
RP Wittbrodt, MT (corresponding author), 1821 Clifton Rd,Room 214, Atlanta, GA 30307 USA.
EM mattwittbrodt@emory.edu
RI Lima, Bruno/AAB-2807-2021; Vaccarino, Viola/AAW-5600-2020; Wittbrodt,
   Matt/AAW-3858-2020; Bremner, James/B-1632-2013
OI Vaccarino, Laura Viola/0000-0002-9054-0654; Wittbrodt,
   Matthew/0000-0002-9533-8041
FU National Institute of Health [P01 HL101398, HL088726, MH076955,
   MH067547-01, MH56120, RR016917, HL077506, HL068630, HL109413, HL125246,
   HL127251, K23 HL127251]
FX This study was supported by National Institute of Health (P01 HL101398,
   HL088726, MH076955, MH067547-01, MH56120, RR016917, HL077506, HL068630,
   HL109413, HL125246, HL127251, and K23 HL127251. Funding sources had no
   involvement in study design, data collection, data analysis,
   interpretation of data, writing of the report, or decision to submit the
   article.
CR Aasted CM, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0165226
   Adamaszek M, 2017, CEREBELLUM, V16, P552, DOI 10.1007/s12311-016-0815-8
   Algladi T, 2015, PAIN, V156, P1348, DOI 10.1097/j.pain.0000000000000187
   [Anonymous], 2011, CARDIOVASC PSYCHIAT, DOI [DOI 10.1155/2011/134040, 10.1155/2011/134040]
   Azen R, 2003, PSYCHOL METHODS, V8, P129, DOI 10.1037/1082-989X.8.2.129
   Azen R, 2009, J EDUC BEHAV STAT, V34, P319, DOI 10.3102/1076998609332754
   Beck A.T., 1996, BDI-II
   Bekkouche NS, 2013, PSYCHOSOM MED, V75, P413, DOI 10.1097/PSY.0b013e31828c4cb4
   Blefari ML, 2017, EUR J NEUROSCI, V45, P1300, DOI 10.1111/ejn.13567
   Bremner JD, 2007, J NERV MENT DIS, V195, P211, DOI 10.1097/01.nmd.0000243824.84651.6c
   Bremner JD, 2018, PSYCHOSOM MED, V80, P515, DOI 10.1097/PSY.0000000000000597
   Bremner JD, 2000, DEPRESS ANXIETY, V12, P1, DOI 10.1002/1520-6394(2000)12:1<1::AID-DA1>3.0.CO;2-W
   Bremner JD, 2003, PSYCHONEUROENDOCRINO, V28, P733, DOI 10.1016/S0306-4530(02)00067-7
   Cameron OG, 2001, PSYCHOSOM MED, V63, P697, DOI 10.1097/00006842-200109000-00001
   Chouchou F, 2019, HUM BRAIN MAPP, V40, P2611, DOI 10.1002/hbm.24548
   Costello A.B., 2019, Practical Assessment, Research, and Evaluation, V10, P7, DOI DOI 10.7275/JYJ1-4868
   Critchley HD, 2000, J PHYSIOL-LONDON, V523, P259, DOI 10.1111/j.1469-7793.2000.t01-1-00259.x
   Danese A, 2012, PHYSIOL BEHAV, V106, P29, DOI 10.1016/j.physbeh.2011.08.019
   Davidson Karina W, 2008, Cleve Clin J Med, V75 Suppl 2, pS15
   de la Vega A, 2016, J NEUROSCI, V36, P6553, DOI 10.1523/JNEUROSCI.4402-15.2016
   DEANFIELD JE, 1984, LANCET, V2, P1001
   Derbyshire Stuart W G, 2007, Curr Pain Headache Rep, V11, P178, DOI 10.1007/s11916-007-0188-2
   Dixon ML, 2017, PSYCHOL BULL, V143, P1033, DOI 10.1037/bul0000096
   Eisen A, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.116.004080
   Fanaroff AC, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.117.007007
   First MB, 2004, Comprehensive Handbook of Psychological Assessment, Vol 2: Personality Assessment, V2, P134, DOI [10.1002/9781118625392.wbecp351, DOI 10.1002/CPP]
   Foreman RD, 2015, COMPR PHYSIOL, V5, P929, DOI 10.1002/cphy.c140032
   Ganos C, 2019, NEUROLOGY, V93, P750, DOI 10.1212/WNL.0000000000008372
   García-Larrea L, 1999, PAIN, V83, P259, DOI 10.1016/S0304-3959(99)00114-1
   Gl_ascher J, 2008, CONTRAST WEIGHTS FLE, P1
   Hammadah M, 2017, PSYCHOSOM MED, V79, P311, DOI 10.1097/PSY.0000000000000442
   Hayek SS, 2017, INT J CARDIOL, V230, P420, DOI 10.1016/j.ijcard.2016.12.091
   Jespersen L, 2012, EUR HEART J, V33, P734, DOI 10.1093/eurheartj/ehr331
   Kano M, 2013, AM J PHYSIOL-GASTR L, V304, pG687, DOI 10.1152/ajpgi.00385.2012
   Kasher N, 2019, BIOL SEX DIFFER, V10, DOI 10.1186/s13293-019-0248-4
   Kimble Laura P, 2002, Heart Dis, V4, P206, DOI 10.1097/00132580-200207000-00002
   Kircher T, 2013, BIOL PSYCHIAT, V73, P93, DOI 10.1016/j.biopsych.2012.07.026
   Kloner RA, 2017, J CARDIOVASC PHARM T, V22, P199, DOI 10.1177/1074248416679733
   Koziol LF, 2014, CEREBELLUM, V13, P151, DOI 10.1007/s12311-013-0511-x
   Kraynak TE, 2018, CURR CARDIOL REP, V20, DOI 10.1007/s11886-018-1071-y
   Kronish IM, 2012, J PSYCHIATR RES, V46, P1595, DOI 10.1016/j.jpsychires.2012.06.011
   Kyriazos T. A., 2018, Psychology, V9, P2044, DOI [DOI 10.4236/PSYCH.2018.98117, 10.4236/psych.2018.98117]
   Lane RD, 1997, AM J PSYCHIAT, V154, P926
   LEINER HC, 1989, BEHAV NEUROSCI, V103, P998, DOI 10.1037/0735-7044.103.5.998
   Lewin B, 1997, J PSYCHOSOM RES, V43, P453, DOI 10.1016/S0022-3999(97)00143-8
   Lupien SJ, 2009, NAT REV NEUROSCI, V10, P434, DOI 10.1038/nrn2639
   McFadden D., 1974, J. Public Econ., V3, P303
   Menard S, 2004, AM STAT, V58, P218, DOI 10.1198/000313004X946
   Mulcahy JS, 2019, NEUROIMAGE, V202, DOI 10.1016/j.neuroimage.2019.116072
   Neeland IJ, 2012, AM HEART J, V164, P547, DOI 10.1016/j.ahj.2012.07.007
   Pai PY, 2003, JPN HEART J, V44, P145, DOI 10.1536/jhj.44.145
   Pimple P, 2018, AM J MED, V131, P540, DOI 10.1016/j.amjmed.2017.11.026
   Pimple P, 2015, J PSYCHOSOM RES, V78, P433, DOI 10.1016/j.jpsychores.2015.02.007
   Reiman EM, 1997, AM J PSYCHIAT, V154, P918
   Rolls ET, 2004, BRAIN COGNITION, V55, P11, DOI 10.1016/s0278-2626(03)00277-x
   Rolls ET, 2003, CEREB CORTEX, V13, P308, DOI 10.1093/cercor/13.3.308
   ROSEN SD, 1994, LANCET, V344, P147, DOI 10.1016/S0140-6736(94)92755-3
   Rosen SD, 1996, ANN INTERN MED, V124, P939, DOI 10.7326/0003-4819-124-11-199606010-00001
   Rosen SD, 2002, HEART, V87, P513, DOI 10.1136/heart.87.6.513
   Rosen SD, 2000, ANN MED, V32, P350, DOI 10.3109/07853890008995938
   Rosen SD, 2012, CAN J CARDIOL, V28, pS7, DOI 10.1016/j.cjca.2011.09.010
   Rugulies R, 2002, AM J PREV MED, V23, P51, DOI 10.1016/S0749-3797(02)00439-7
   Saab CY, 2001, EXP BRAIN RES, V140, P122
   Schmand M, 1999, IEEE NUCL SCI CONF R, P1067, DOI 10.1109/NSSMIC.1999.845845
   Scott JC, 2015, PSYCHOL BULL, V141, P105, DOI 10.1037/a0038039
   Sheffield D, 1999, AM J CARDIOL, V83, P106, DOI 10.1016/S0002-9149(98)00790-5
   Sheps DS, 1999, J AM COLL CARDIOL, V33, P1855, DOI 10.1016/S0735-1097(99)00099-6
   Spertus JA, 2002, CIRCULATION, V106, P43, DOI 10.1161/01.CIR.0000020688.24874.90
   SPERTUS JA, 1995, J AM COLL CARDIOL, V25, P333, DOI 10.1016/0735-1097(94)00397-9
   Strigo IA, 2003, J NEUROPHYSIOL, V89, P3294, DOI 10.1152/jn.01048.2002
   Sullivan MD, 2008, PAIN, V139, P551, DOI 10.1016/j.pain.2008.06.009
   Sun SS, 2001, J NEUROIMAGING, V11, P148, DOI 10.1111/j.1552-6569.2001.tb00025.x
   TAKAYANAGI K, 1992, JPN HEART J, V33, P25
   Takizawa R, 2014, CEREB CORTEX, V24, P1858, DOI 10.1093/cercor/bht036
   Talairach G., 1988, Planar Stereotaxic Atlas of the Human Brain
   Tzourio-Mazoyer N, 2002, NEUROIMAGE, V15, P273, DOI 10.1006/nimg.2001.0978
   Urien L, 2019, PSYCHOSOM MED, V81, P851, DOI 10.1097/PSY.0000000000000744
   Vaccarino V, 2013, BIOL PSYCHIAT, V74, P790, DOI 10.1016/j.biopsych.2013.10.002
   Vaccarino V, 2013, J AM COLL CARDIOL, V62, P970, DOI 10.1016/j.jacc.2013.04.085
   Vaccarino V, 2009, ARCH INTERN MED, V169, P1668, DOI 10.1001/archinternmed.2009.330
   Wei JK, 2014, AM J CARDIOL, V114, P187, DOI 10.1016/j.amjcard.2014.04.022
   Whooley MA, 2008, JAMA-J AM MED ASSOC, V300, P2379, DOI 10.1001/jama.2008.711
   Wittbrodt MT, 2020, HEALTH PSYCHOL, V39, P679, DOI 10.1037/hea0000856
   Wittbrodt MT, 2019, J AFFECT DISORDERS, V254, P49, DOI 10.1016/j.jad.2019.05.018
   Zen AL, 2012, HEALTH PSYCHOL, V31, P194, DOI 10.1037/a0025989
NR 85
TC 9
Z9 9
U1 0
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD JUL
PY 2020
VL 134
AR 110110
DI 10.1016/j.jpsychores.2020.110110
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA LU3NS
UT WOS:000537666700002
PM 32345456
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Obulhasim, G
   Yasen, M
   Kajino, K
   Mogushi, K
   Tanaka, S
   Mizushima, H
   Tanaka, H
   Arii, S
   Hino, O
AF Obulhasim, Gulanbar
   Yasen, Mahmut
   Kajino, Kazunori
   Mogushi, Kaoru
   Tanaka, Shinji
   Mizushima, Hiroshi
   Tanaka, Hiroshi
   Arii, Shigeki
   Hino, Okio
TI Up-regulation of dbpA mRNA in hepatocellular carcinoma associated with
   metabolic syndrome
SO HEPATOLOGY INTERNATIONAL
LA English
DT Article
DE Hepatocellular carcinoma; Metabolic syndrome; dbpA expression; Oxidative
   stress
ID BOX-BINDING PROTEIN; NONALCOHOLIC STEATOHEPATITIS; METHYLATION STATUS;
   NATURAL-HISTORY; LIVER-DISEASE; HEPATITIS; CIRRHOSIS; RISK; OBESITY;
   INCREASES
AB Metabolic syndrome (MS) is a group of recognized risk factors for the development of hepatocellular carcinoma (HCC) in patients with chronic liver disease. The aim of this study was to analyze the clinicopathological characteristics of HCC patients with MS and the risk factors for recurrence. Also, the aim was to investigate the cold shock protein: DNA-binding protein A (dbpA) expression in HCC patients with MS.
   A total of 243 patients who underwent curative resections for HCC were classified into two groups. dbpA expression was investigated in 66 HCC patients with MS and in 30 patients without MS by using real-time RT-PCR. Promoter methylation status was examined by using MS-PCR.
   The incidence of metabolic factors affect the HCC significantly higher in non-B non-C patients than in hepatitis B virus (HBV) or hepatitis C virus (HCV) patients (P < 0.001). Univariate analysis of HCC patients with MS recurrence revealed aspartate amino transferase (AST), multiple tumors, liver damage, hepatic vein invasion, advanced cancer stages (P < 0.01), alpha-fetoprotein (AFP) and diabetes mellitus type II (P < 0.05) as risk factors. Multivariate analysis, AST, multiple tumors, and hepatic vein invasion (P < 0.01) were identified as independent factors for the recurrence. dbpA mRNA was higher in patients with MS than in those without MS (P = 0.016), and it was mostly upregulated in non-B non-C HCC patients with MS than in non-B non-C HCC patients without HBV or HCV. Especially, in HCC patients with diabetes mellitus type II, the mRNA and protein levels were highly upregulated. The dbpA expression was regulated by promoter methylation status (P < 0.05).
   This study identifies that dbpA may accelerate the hepatocarcinogenesis in HCC patients with MS via inflammation-induced and oxidative stress pathways. The demethylation-related epigenetic activation may be one of the regulating factors for HCC patients with MS.
C1 [Obulhasim, Gulanbar; Kajino, Kazunori; Hino, Okio] Juntendo Univ, Sch Med, Dept Pathol & Oncol, Bunkyo Ku, Tokyo 1138421, Japan.
   [Obulhasim, Gulanbar; Yasen, Mahmut] Xinjiang Med Univ, Xinjiang Uyghur Tumor Hosp, Dept Surg, Urumqi 830011, Xinjiang, Peoples R China.
   [Yasen, Mahmut; Tanaka, Shinji; Arii, Shigeki] Tokyo Med & Dent Univ, Dept Hepatobiliary Pancreat Surg, Bunkyo Ku, Tokyo 1138510, Japan.
   [Mogushi, Kaoru; Mizushima, Hiroshi; Tanaka, Hiroshi] Tokyo Med & Dent Univ, Dept Computat Biol & Bioinformat, Bunkyo Ku, Tokyo 1138510, Japan.
C3 Juntendo University; Xinjiang Medical University; Institute of Science
   Tokyo; Tokyo Medical & Dental University (TMDU); Institute of Science
   Tokyo; Tokyo Medical & Dental University (TMDU)
RP Yasen, M (corresponding author), Tokyo Med & Dent Univ, Dept Hepatobiliary Pancreat Surg, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138510, Japan.
EM mahmut@bioinfo.tmd.ac.jp
OI Mogushi, Kaoru/0000-0002-2618-8684
FU Special Coordination Funds for Promoting Science and Technology (Japan
   Science and Technology Agency); Ministry of Education, Culture, Sports,
   Science and Technology of Japan
FX This work was supported by Special Coordination Funds for Promoting
   Science and Technology (Japan Science and Technology Agency), and a
   Grant-in-Aid from Ministry of Education, Culture, Sports, Science and
   Technology of Japan.
CR Arakawa Y, 2004, BIOCHEM BIOPH RES CO, V322, P297, DOI 10.1016/j.bbrc.2004.04.208
   Bosch FX, 2004, GASTROENTEROLOGY, V127, pS5, DOI 10.1053/j.gastro.2004.09.011
   Brugts MP, 2010, DIABETES, V59, P505, DOI 10.2337/db09-0583
   Bugianesi E, 2002, GASTROENTEROLOGY, V123, P134, DOI 10.1053/gast.2002.34168
   Caldwell SH, 2004, GASTROENTEROLOGY, V127, pS97, DOI 10.1053/j.gastro.2004.09.021
   El-Serag HB, 2004, GASTROENTEROLOGY, V126, P460, DOI 10.1053/j.gastro.2003.10.065
   El-Serag HB, 1999, NEW ENGL J MED, V340, P745, DOI 10.1056/NEJM199903113401001
   Herman JG, 1996, P NATL ACAD SCI USA, V93, P9821, DOI 10.1073/pnas.93.18.9821
   Hind O, 2002, J GASTROENTEROL, V37, P883, DOI 10.1007/s005350200149
   Hui JM, 2003, HEPATOLOGY, V38, P420, DOI 10.1053/jhep.2003.50320
   Kajino K, 2001, INTERVIROLOGY, V44, P311, DOI 10.1159/000050063
   Lagiou P, 2000, J NATL CANCER I, V92, P1096, DOI 10.1093/jnci/92.13.1096
   MARKS F, 1978, CARCINOGENESIS, V2, P97
   Marrero JA, 2002, HEPATOLOGY, V36, P1349, DOI 10.1053/jhep.2002.36939
   Paradis V, 2009, HEPATOLOGY, V49, P851, DOI 10.1002/hep.22734
   POWELL EE, 1990, HEPATOLOGY, V11, P74, DOI 10.1002/hep.1840110114
   Ratziu V, 2002, HEPATOLOGY, V35, P1485, DOI 10.1053/jhep.2002.33324
   Regimbeau Jean M, 2004, Liver Transpl, V10, pS69, DOI 10.1002/lt.20033
   SAKURA H, 1988, GENE, V73, P499
   Siegel AB, 2009, CANCER-AM CANCER SOC, V115, P5651, DOI 10.1002/cncr.24687
   Tarao K, 1997, CANCER, V79, P688, DOI 10.1002/(SICI)1097-0142(19970215)79:4<688::AID-CNCR5>3.0.CO;2-A
   Tellez-Avila FI, 2008, WORLD J GASTROENTERO, V14, P4771, DOI 10.3748/wjg.14.4771
   Tobita H, 2006, INT J ONCOL, V29, P673
   Umeda T, 2002, ONCOLOGY-BASEL, V62, P38, DOI 10.1159/000048274
   WOLFFE AP, 1992, NEW BIOL, V4, P290
   Wong GLH, 2009, GUT, V58, P111, DOI 10.1136/gut.2008.157735
   Yasen M, 2005, CLIN CANCER RES, V11, P7354, DOI 10.1158/1078-0432.CCR-05-1027
   Yasen M, 2012, INT J ONCOL, V40, P789, DOI 10.3892/ijo.2011.1282
   Yu MC, 2004, GASTROENTEROLOGY, V127, pS72, DOI 10.1016/j.gastro.2004.09.018
   Yuan JM, 2004, CANCER, V101, P1009, DOI 10.1002/cncr.20427
   Zen Y, 2001, PATHOL INT, V51, P127, DOI 10.1046/j.1440-1827.2001.01174.x
NR 31
TC 3
Z9 3
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1936-0533
EI 1936-0541
J9 HEPATOL INT
JI Hepatol. Int.
PD MAR
PY 2013
VL 7
IS 1
BP 215
EP 225
DI 10.1007/s12072-012-9357-4
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 109FC
UT WOS:000316350600026
PM 26201636
DA 2025-06-11
ER

PT J
AU Saxbe, D
   Corner, GW
   Khaled, M
   Horton, K
   Wu, B
   Khoddam, HL
AF Saxbe, Darby
   Corner, Geoffrey W.
   Khaled, Mona
   Horton, Katelyn
   Wu, Brian
   Khoddam, Hannah Lyden
TI The weight of fatherhood: identifying mechanisms to explain paternal
   perinatal weight gain
SO HEALTH PSYCHOLOGY REVIEW
LA English
DT Article
DE Fathers; weight; obesity; adiposity; paternal; testosterone; HPA axis;
   sleep; physical activity; exercise; mood disorders; couples
ID SHORT-SLEEP DURATION; BODY-MASS INDEX; STRESSFUL LIFE EVENTS; 12 MONTHS
   POSTPARTUM; PHYSICAL-ACTIVITY; UNITED-STATES; SERUM TESTOSTERONE;
   METABOLIC SYNDROME; CHILDHOOD OBESITY; INDIVIDUAL VARIATION
AB Men appear to gain weight during the transition to parenthood, and fathers are heavier than non-fathers. Paternal perinatal weight gain may set weight trajectories in midlife and have long-term health implications. Since men do not undergo the physical demands of pregnancy and breastfeeding, the specific mechanisms underlying weight gain in new fathers warrant investigation. This review aims to stimulate research on paternal perinatal weight gain by suggesting testable potential mechanisms that (1) show change across the transition to parenthood and (2) play a role in weight and body composition. We identify seven mechanisms, within three categories: behavioural mechanisms (sleep, physical activity, and diet), hormonal mechanisms (testosterone and cortisol), and psychological mechanisms (depression and stress). We also discuss direct effects of partner pregnancy influences (e.g., couvade syndrome') on men's body weight. In presenting each mechanism, we discuss how it may be affected by the transition to parenthood, and then review its role in body composition and weight. Next, we describe bidirectional and interactive effects, discuss timing, and present three broad research questions to propel theoretical development.
C1 [Saxbe, Darby; Corner, Geoffrey W.; Khaled, Mona; Horton, Katelyn; Khoddam, Hannah Lyden] Univ Southern Calif, Dept Psychol, Los Angeles, CA 90007 USA.
   [Wu, Brian] Univ Southern Calif, Keck Sch Med, Los Angeles, CA USA.
C3 University of Southern California; University of Southern California
RP Saxbe, D (corresponding author), Univ Southern Calif, Dept Psychol, Los Angeles, CA 90007 USA.
EM dsaxbe@usc.edu
FU National Science Foundation CAREER Award [1552452]; National Science
   Foundation Graduate Research Fellowship; Division Of Behavioral and
   Cognitive Sci; Direct For Social, Behav & Economic Scie [1552452]
   Funding Source: National Science Foundation
FX This work was funded by the National Science Foundation CAREER Award to
   D. S. [grant number 1552452], and a National Science Foundation Graduate
   Research Fellowship to G. W. C.
CR Abraham SB, 2013, OBESITY, V21, pE105, DOI 10.1002/oby.20083
   Acebo C, 2005, SLEEP, V28, P1568, DOI 10.1093/sleep/28.12.1568
   Barry D, 2008, PREV MED, V47, P498, DOI 10.1016/j.ypmed.2008.08.006
   Bellows-Riecken KH, 2008, PREV MED, V46, P99, DOI 10.1016/j.ypmed.2007.08.003
   Berge JM, 2011, PEDIATRICS, V127, P881, DOI 10.1542/peds.2010-3218
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   Björntorp P, 2000, NUTRITION, V16, P924, DOI 10.1016/S0899-9007(00)00422-6
   Blaak E, 2001, CURR OPIN CLIN NUTR, V4, P499, DOI 10.1097/00075197-200111000-00006
   Blaine B, 2008, J HEALTH PSYCHOL, V13, P1190, DOI 10.1177/1359105308095977
   Bojesen A, 2006, DIABETES CARE, V29, P1591, DOI 10.2337/dc06-0145
   Braga-Basaria M, 2006, J CLIN ONCOL, V24, P3979, DOI 10.1200/JCO.2006.05.9741
   Braveman PA, 2010, AM J PUBLIC HEALTH, V100, pS186, DOI 10.2105/AJPH.2009.166082
   Brennan A, 2007, J REPROD INFANT PSYC, V25, P18, DOI 10.1080/02646830601117142
   Burgard SA, 2013, AM SOCIOL REV, V78, P51, DOI 10.1177/0003122412472048
   Buxton OM, 2010, SOC SCI MED, V71, P1027, DOI 10.1016/j.socscimed.2010.05.041
   Cappuccio FP, 2008, SLEEP, V31, P619, DOI 10.1093/sleep/31.5.619
   Caspersen CJ, 2000, MED SCI SPORT EXER, V32, P1601
   Chaput JP, 2007, OBESITY, V15, P253, DOI 10.1038/oby.2007.512
   Chen XL, 2008, OBESITY, V16, P265, DOI 10.1038/oby.2007.63
   Chida Y, 2009, BIOL PSYCHOL, V80, P265, DOI 10.1016/j.biopsycho.2008.10.004
   Clark MM, 2000, ANIM BEHAV, V59, P801, DOI 10.1006/anbe.1999.1365
   Cogswell ME, 1999, OBSTET GYNECOL, V94, P616, DOI 10.1016/S0029-7844(99)00375-0
   Craig L, 2010, J MARRIAGE FAM, V72, P1344, DOI 10.1111/j.1741-3737.2010.00769.x
   Davison KK, 2018, PREV MED, V111, P170, DOI 10.1016/j.ypmed.2018.02.029
   Edelstein RS, 2015, AM J HUM BIOL, V27, P317, DOI 10.1002/ajhb.22670
   Edvardsson K, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-923
   Engberg E, 2012, SPORTS MED, V42, P433, DOI 10.2165/11597610-000000000-00000
   Epel E, 2001, PSYCHONEUROENDOCRINO, V26, P37, DOI 10.1016/S0306-4530(00)00035-4
   Finkelstein JS, 2013, NEW ENGL J MED, V369, P1011, DOI 10.1056/NEJMoa1206168
   Fleming AS, 2002, HORM BEHAV, V42, P399, DOI 10.1006/hbeh.2002.1840
   Freeman E, 2012, INT J OBESITY, V36, P12, DOI 10.1038/ijo.2011.198
   Gardner B, 2011, OBES REV, V12, pE602, DOI 10.1111/j.1467-789X.2011.00884.x
   Garfield CF, 2016, AM J MENS HEALTH, V10, pN158, DOI 10.1177/1557988315596224
   Genesoni L, 2009, BIRTH-ISS PERINAT C, V36, P305, DOI 10.1111/j.1523-536X.2009.00358.x
   Gettler LT, 2017, EVOL MED PUBLIC HLTH, P67, DOI 10.1093/emph/eox005
   Gettler LT, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041559
   Gettler LT, 2011, P NATL ACAD SCI USA, V108, P16194, DOI 10.1073/pnas.1105403108
   Goodlin-Jones BL, 2001, J DEV BEHAV PEDIATR, V22, P226, DOI 10.1097/00004703-200108000-00003
   Gore SA, 2003, ANN BEHAV MED, V26, P149, DOI 10.1207/S15324796ABM2602_07
   Gray PB, 2007, HORM BEHAV, V52, P499, DOI 10.1016/j.yhbeh.2007.07.005
   Greaves C, 2017, HEALTH PSYCHOL REV, V11, P145, DOI 10.1080/17437199.2017.1299583
   Gunderson EP, 2008, OBESITY, V16, P1078, DOI 10.1038/oby.2008.40
   Hagen EW, 2013, AM J EPIDEMIOL, V177, P394, DOI 10.1093/aje/kws246
   Handelsman DJ, 2013, NEW ENGL J MED, V369, P1058, DOI 10.1056/NEJMe1305307
   Harsch IA, 2003, EUR RESPIR J, V22, P251, DOI 10.1183/09031936.03.00010103
   Henderson JMT, 2011, SLEEP MED REV, V15, P211, DOI 10.1016/j.smrv.2010.08.003
   Herring SJ, 2008, OBESITY, V16, P1296, DOI 10.1038/oby.2008.71
   Hull EE, 2010, J PHYS ACT HEALTH, V7, P577, DOI 10.1123/jpah.7.5.577
   Jackson SE, 2017, OBESITY, V25, P539, DOI 10.1002/oby.21733
   Jackson SE, 2016, OBESITY, V24, P2515, DOI 10.1002/oby.21657
   Jeffery RW, 2002, OBES RES, V10, P809, DOI 10.1038/oby.2002.109
   Katan MB, 2010, JAMA-J AM MED ASSOC, V303, P65, DOI 10.1001/jama.2009.1912
   Kelly DM, 2015, OBES REV, V16, P581, DOI 10.1111/obr.12282
   Kim P, 2014, SOC NEUROSCI-UK, V9, P522, DOI 10.1080/17470919.2014.933713
   Krueger PM, 2009, AM J EPIDEMIOL, V169, P1052, DOI 10.1093/aje/kwp023
   Kumari M, 2010, J CLIN ENDOCR METAB, V95, P4415, DOI 10.1210/jc.2009-2105
   Kuo PX, 2016, DEV PSYCHOBIOL, V58, P303, DOI 10.1002/dev.21370
   LEMASTERS EE, 1957, MARRIAGE FAM LIVING, V19, P352, DOI 10.2307/347802
   LIPKIN M, 1982, ANN INTERN MED, V96, P509, DOI 10.7326/0003-4819-96-4-509
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Mary R., 2014, COUVADE SYNDROME MAL
   McDaniel BT, 2012, J FAM PSYCHOL, V26, P886, DOI 10.1037/a0030707
   Mezuk B, 2010, AM J EPIDEMIOL, V172, P1238, DOI 10.1093/aje/kwq283
   Nasuti G, 2014, J ACAD NUTR DIET, V114, P450, DOI 10.1016/j.jand.2013.07.042
   Navarro G, 2015, OBESITY, V23, P713, DOI 10.1002/oby.21033
   Nishiura C, 2010, SLEEP, V33, P753, DOI 10.1093/sleep/33.6.753
   Nyberg ST, 2012, J INTERN MED, V272, P65, DOI 10.1111/j.1365-2796.2011.02482.x
   Ohlsson C, 2011, J AM COLL CARDIOL, V58, P1674, DOI 10.1016/j.jacc.2011.07.019
   Ostbye T, 2009, AM J PREV MED, V37, P173, DOI 10.1016/j.amepre.2009.05.016
   Ostbye T, 2011, INT J EPIDEMIOL, V40, P240, DOI 10.1093/ije/dyq142
   Patel SR, 2008, OBESITY, V16, P643, DOI 10.1038/oby.2007.118
   Paulson JF, 2010, JAMA-J AM MED ASSOC, V303, P1961, DOI 10.1001/jama.2010.605
   Pedersen P, 2011, OBESITY, V19, P639, DOI 10.1038/oby.2010.175
   PERRIGO G, 1991, PHYSIOL BEHAV, V50, P287, DOI 10.1016/0031-9384(91)90068-Y
   Phelan S, 2014, AM J CLIN NUTR, V99, P302, DOI 10.3945/ajcn.113.070151
   Phillips J, 2014, J REPROD INFANT PSYC, V32, P25, DOI 10.1080/02646838.2013.845873
   Prather AA, 2017, ANN BEHAV MED, V51, P137, DOI 10.1007/s12160-016-9835-3
   Rhoades GK, 2012, J FAM ISSUES, V33, P369, DOI 10.1177/0192513X11420940
   Rhodes RE, 2014, J BEHAV MED, V37, P533, DOI 10.1007/s10865-013-9508-7
   Rodriguez ACI, 2015, PSYCHONEUROENDOCRINO, V62, P301, DOI 10.1016/j.psyneuen.2015.08.014
   Rogers SL, 2016, CLIN ENDOCRINOL, V85, P881, DOI 10.1111/cen.13150
   Rooney BL, 2005, OBSTET GYNECOL, V106, P1349, DOI 10.1097/01.AOG.0000185480.09068.4a
   Saltzman W, 2014, J NEUROENDOCRINOL, V26, P685, DOI 10.1111/jne.12176
   Sandman CA, 2006, PEPTIDES, V27, P1457, DOI 10.1016/j.peptides.2005.10.002
   Saxbe D, 2010, J PERS SOC PSYCHOL, V98, P92, DOI 10.1037/a0016959
   Saxbe DE, 2017, HORM BEHAV, V90, P39, DOI 10.1016/j.yhbeh.2016.07.005
   Saxbe DE, 2016, ANN BEHAV MED, V50, P862, DOI 10.1007/s12160-016-9815-7
   Saxbe DE, 2015, PSYCHONEUROENDOCRINO, V62, P121, DOI 10.1016/j.psyneuen.2015.08.006
   Siega-Riz AM, 2010, OBESITY, V18, P1996, DOI 10.1038/oby.2009.458
   Soczynska JK, 2011, NEUROMOL MED, V13, P93, DOI 10.1007/s12017-010-8140-8
   Spiegel K, 2004, ANN INTERN MED, V141, P846, DOI 10.7326/0003-4819-141-11-200412070-00008
   Stamatakis KA, 2010, CHEST, V137, P95, DOI 10.1378/chest.09-0791
   Storey AE, 2000, EVOL HUM BEHAV, V21, P79, DOI 10.1016/S1090-5138(99)00042-2
   Storey AE, 2011, HORM BEHAV, V60, P353, DOI 10.1016/j.yhbeh.2011.07.001
   Straub H, 2016, MATERN CHILD HLTH J, V20, P1375, DOI 10.1007/s10995-016-1934-z
   Strine TW, 2008, GEN HOSP PSYCHIAT, V30, P127, DOI 10.1016/j.genhosppsych.2007.12.008
   Taheri S, 2004, PLOS MED, V1, P210, DOI 10.1371/journal.pmed.0010062
   Tang JCH, 2016, HEALTH PSYCHOL REV, V10, P358, DOI 10.1080/17437199.2016.1172979
   Taveras EM, 2011, OBESITY, V19, P171, DOI 10.1038/oby.2010.117
   Thangaratinam S, 2012, BMJ-BRIT MED J, V344, DOI 10.1136/bmj.e2088
   Torres SJ, 2007, NUTRITION, V23, P887, DOI 10.1016/j.nut.2007.08.008
   Travison TG, 2007, CLIN ENDOCRINOL, V67, P71, DOI 10.1111/j.1365-2265.2007.02837.x
   Tyagi Vineet, 2017, Rev Urol, V19, P16
   Umberson D, 2011, SOC SCI MED, V73, P1323, DOI 10.1016/j.socscimed.2011.08.014
   van Anders SM, 2012, HORM BEHAV, V61, P31, DOI 10.1016/j.yhbeh.2011.09.012
   van den Beld AW, 2000, J CLIN ENDOCR METAB, V85, P3276, DOI 10.1210/jc.85.9.3276
   Weng HLH, 2004, J WOMENS HEALTH, V13, P85, DOI 10.1089/154099904322836492
   Whitaker K, 2014, MATERN CHILD HLTH J, V18, P2209, DOI 10.1007/s10995-014-1470-7
   Williams PT, 2006, INT J OBESITY, V30, P543, DOI 10.1038/sj.ijo.0803172
   WILLIAMSON DF, 1993, INT J OBESITY, V17, P279
   World Obesity Federation, 2017, WORLD OB DAY CAMP TO
   Wynne-Edwards KE, 2001, HORM BEHAV, V40, P139, DOI 10.1006/hbeh.2001.1699
   Young MD, 2017, AM J LIFESTYLE MED, V11, P212, DOI 10.1177/1559827616689544
   Ziegler TE, 2006, BIOL LETT-UK, V2, P181, DOI 10.1098/rsbl.2005.0426
   Zitzmann M, 2006, J CLIN ENDOCR METAB, V91, P4335, DOI 10.1210/jc.2006-0401
NR 115
TC 26
Z9 26
U1 0
U2 27
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1743-7199
EI 1743-7202
J9 HEALTH PSYCHOL REV
JI Health Psychol. Rev.
PY 2018
VL 12
IS 3
BP 294
EP 311
DI 10.1080/17437199.2018.1463166
PG 18
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA GP7DK
UT WOS:000441052500005
PM 29712505
DA 2025-06-11
ER

PT J
AU Kolb, H
   Martin, S
AF Kolb, Hubert
   Martin, Stephan
TI Environmental/lifestyle factors in the pathogenesis and prevention of
   type 2 diabetes
SO BMC MEDICINE
LA English
DT Review
DE Type 2 diabetes; Environment; Lifestyle; Diabetes risk factors; Diabetes
   prevention; Diet; Physical activity; beta-cells
ID BETA-CELL FUNCTION; Y GASTRIC BYPASS; DOSE-RESPONSE METAANALYSIS; FATTY
   LIVER-DISEASE; C-REACTIVE PROTEIN; ALL-CAUSE MORTALITY; LONG-TERM
   EXPOSURE; LOW-CALORIE DIET; INSULIN SENSITIVITY; METABOLIC SYNDROME
AB Background: Environmental and lifestyle changes, in addition to the ageing of populations, are generally believed to account for the rapid global increase in type 2 diabetes prevalence and incidence in recent decades.
   Discussion: In this review, we present a comprehensive overview of factors contributing to diabetes risk, including aspects of diet quality and quantity, little physical activity, increased monitor viewing time or sitting in general, exposure to noise or fine dust, short or disturbed sleep, smoking, stress and depression, and a low socioeconomic status. In general, these factors promote an increase in body mass index. Since loss of beta-cell function is the ultimate cause of developing overt type 2 diabetes, environmental and lifestyle changes must have resulted in a higher risk of beta-cell damage in those at genetic risk. Multiple mechanistic pathways may come into play.
   Conclusions: Strategies of diabetes prevention should aim at promoting a 'diabetes-protective lifestyle' whilst simultaneously enhancing the resistance of the human organism to pro-diabetic environmental and lifestyle factors. More research on diabetes-protective mechanisms seems warranted.
C1 [Kolb, Hubert; Martin, Stephan] Univ Duesseldorf, Fac Med, Dusseldorf, Germany.
   [Kolb, Hubert; Martin, Stephan] Duesseldorf Catholic Hosp Grp, West German Ctr Diabet & Hlth, Hohensandweg 37, D-40591 Dusseldorf, Germany.
RP Kolb, H (corresponding author), Univ Duesseldorf, Fac Med, Dusseldorf, Germany.; Kolb, H (corresponding author), Duesseldorf Catholic Hosp Grp, West German Ctr Diabet & Hlth, Hohensandweg 37, D-40591 Dusseldorf, Germany.
EM hubert.kolb@uni-duesseldorf.de
FU Gesellschaft von Freunden und Forderern der Heinrich-Heine-Universitat
   Dusseldorf e.V.
FX This work was supported by the Gesellschaft von Freunden und Forderern
   der Heinrich-Heine-Universitat Dusseldorf e.V.
CR Agardh E, 2011, INT J EPIDEMIOL, V40, P804, DOI 10.1093/ije/dyr029
   Almgren M, 2014, ANN MED, V46, P539, DOI 10.3109/07853890.2014.935469
   Almgren M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0041652
   Amyot J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036200
   [Anonymous], LIVER INT
   Atallah R, 2014, CIRC-CARDIOVASC QUAL, V7, P815, DOI 10.1161/CIRCOUTCOMES.113.000723
   Au B, 2014, J PSYCHOSOM RES, V77, P180, DOI 10.1016/j.jpsychores.2014.07.012
   Aune D, 2015, EUR J EPIDEMIOL, V30, P529, DOI 10.1007/s10654-015-0056-z
   Ballestri S, 2016, J GASTROEN HEPATOL, V31, P936, DOI 10.1111/jgh.13264
   Bao Y, 2013, NEW ENGL J MED, V369, P2001, DOI 10.1056/NEJMoa1307352
   Berchtold LA, 2016, ADV CLIN CHEM, V75, P99, DOI 10.1016/bs.acc.2016.02.001
   Bergmann N, 2014, ENDOCR CONNECT, V3, pR55, DOI 10.1530/EC-14-0031
   Berk M, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-74
   Biswas A, 2015, ANN INTERN MED, V162, P123, DOI 10.7326/M14-1651
   Blüher M, 2014, EUR J ENDOCRINOL, V171, pR209, DOI 10.1530/EJE-14-0540
   Boets E, 2017, J PHYSIOL-LONDON, V595, P541, DOI 10.1113/JP272613
   Bonnefond A, 2015, CELL METAB, V21, P357, DOI 10.1016/j.cmet.2014.12.020
   Brandsma E, 2015, CURR OPIN LIPIDOL, V26, P73, DOI 10.1097/MOL.0000000000000154
   Brewer Rachel A, 2016, Nutr Healthy Aging, V4, P31, DOI 10.3233/NHA-160007
   Brun T, 2016, BBA-MOL CELL RES, V1863, P2540, DOI 10.1016/j.bbamcr.2016.03.012
   Buettner Dan., 2005, The Secrets of Long Life
   Butler AE, 2016, J CLIN ENDOCR METAB, V101, P523, DOI 10.1210/jc.2015-3566
   Cai D, 2016, NUTRIENTS, V8, DOI 10.3390/nu8090564
   Cao Y, 2016, J DIABETES COMPLICAT, V30, P178, DOI 10.1016/j.jdiacomp.2015.08.022
   Carter A, 2016, ANNU REV NUTR, V36, P105, DOI 10.1146/annurev-nutr-071715-050909
   Cespedes EM, 2016, AM J EPIDEMIOL, V183, P622, DOI 10.1093/aje/kwv241
   Chaston TB, 2008, INT J OBESITY, V32, P619, DOI 10.1038/sj.ijo.0803761
   Chatterjee S, 2017, LANCET, V389, P2239, DOI 10.1016/S0140-6736(17)30058-2
   Chen JC, 2008, ENVIRON HEALTH PERSP, V116, P612, DOI 10.1289/ehp.10565
   Chennaoui M, 2011, CYTOKINE, V56, P318, DOI 10.1016/j.cyto.2011.06.002
   Choi J, 2013, OBES REV, V14, P232, DOI 10.1111/obr.12003
   Cosgrove MP, 2012, OCCUP MED-OXFORD, V62, P167, DOI 10.1093/occmed/kqs002
   de Vries MA, 2014, ADV EXP MED BIOL, V824, P161, DOI 10.1007/978-3-319-07320-0_12
   Delahanty LM, 2014, DIABETES CARE, V37, P2738, DOI 10.2337/dc14-0018
   Delzenne NM, 2015, DIABETOLOGIA, V58, P2206, DOI 10.1007/s00125-015-3712-7
   Demakakos P, 2014, PSYCHOSOM MED, V76, P555, DOI 10.1097/PSY.0000000000000082
   Dempsey PC, 2016, CURR DIABETES REP, V16, DOI 10.1007/s11892-016-0797-4
   Ding C, 2016, CURR OPIN CLIN NUTR, V19, P408, DOI 10.1097/MCO.0000000000000317
   Ding M, 2014, DIABETES CARE, V37, P569, DOI 10.2337/dc13-1203
   DiPietro L, 2013, DIABETES CARE, V36, P3262, DOI 10.2337/dc13-0084
   Donga E, 2010, J CLIN ENDOCR METAB, V95, P2963, DOI 10.1210/jc.2009-2430
   Dooko CBA, 2014, JAIDS-J ACQ IMM DEF, V67, P538, DOI 10.1097/QAI.0000000000000354
   Dzhambov AM, 2015, NOISE HEALTH, V17, P23, DOI 10.4103/1463-1741.149571
   Ertunc ME, 2016, J LIPID RES, V57, P2099, DOI 10.1194/jlr.R066514
   Esparza-Romero J, 2015, DIABETES CARE, V38, P2075, DOI 10.2337/dc15-0089
   Eze IC, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0130337
   Fardet A, 2014, NUTR REV, V72, P741, DOI 10.1111/nure.12153
   Festi D, 2014, WORLD J GASTROENTERO, V20, P16079, DOI 10.3748/wjg.v20.i43.16079
   Ford AH, 2015, AM J GERIAT PSYCHIAT, V23, P872, DOI 10.1016/j.jagp.2014.10.010
   Forouhi Nita G, 2014, Curr Nutr Rep, V3, P355
   Fuchsberger C, 2016, NATURE, V536, P41, DOI 10.1038/nature18642
   Gabel L, 2016, PEDIATR OBES, V11, P194, DOI 10.1111/ijpo.12045
   Gallagher D, 2014, DIABETES CARE, V37, P3325, DOI 10.2337/dc14-1585
   Gepner Y, 2015, ANN INTERN MED, V163, P569, DOI 10.7326/M14-1650
   Gjevestad GO, 2015, CURR CARDIOVASC RISK, V9, DOI 10.1007/s12170-015-0463-4
   Gnauck A, 2016, INT REV IMMUNOL, V35, P189, DOI 10.3109/08830185.2015.1087518
   Golubic R, 2015, INT J OBESITY, V39, P142, DOI 10.1038/ijo.2014.66
   Gong QH, 2015, INTERNAL MED, V54, P303, DOI 10.2169/internalmedicine.54.2745
   Greenwood DC, 2014, BRIT J NUTR, V112, P725, DOI 10.1017/S0007114514001329
   Hamilton MT, 2014, MED SPORT SCI, V60, P11, DOI 10.1159/000357332
   Hardoon SL, 2010, DIABETES CARE, V33, P1494, DOI 10.2337/dc09-2295
   Hasan SS, 2014, DIABETES METAB SYND, V8, P82, DOI 10.1016/j.dsx.2014.04.023
   Heidemann C, 2014, DIABETIC MED, V31, P1269, DOI 10.1111/dme.12480
   Henson J, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0078350
   Herder C, 2015, TRENDS ENDOCRIN MET, V26, P551, DOI 10.1016/j.tem.2015.08.001
   Herieka M, 2014, MOL NUTR FOOD RES, V58, P136, DOI 10.1002/mnfr.201300104
   Hill AM, 2015, AM J CLIN NUTR, V102, P757, DOI 10.3945/ajcn.114.104026
   Howells L, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2016-013806
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Isbell JM, 2010, DIABETES CARE, V33, P1438, DOI 10.2337/dc09-2107
   Jannasch F, 2017, J NUTR, V147, P1174, DOI 10.3945/jn.116.242552
   Johns DJ, 2014, J ACAD NUTR DIET, V114, P1557, DOI 10.1016/j.jand.2014.07.005
   Jorgensen NB, 2015, J CLIN ENDOCR METAB, V100, pE396, DOI 10.1210/jc.2014-1658
   Kaneto H, 2015, CURR DIABETES REV, V11, P2, DOI 10.2174/1573399811666141216160217
   Keating SE, 2012, J HEPATOL, V57, P157, DOI 10.1016/j.jhep.2012.02.023
   Keith RJ, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0157592
   Kempf K, 2014, J HUM NUTR DIET, V27, P21, DOI 10.1111/jhn.12145
   Kempf K, 2015, EUR J NUTR, V54, P845, DOI 10.1007/s00394-014-0763-3
   Khambaty T, 2017, J AM GERIATR SOC, V65, P294, DOI 10.1111/jgs.14454
   Kiecolt-Glaser JK, 2015, AM J PSYCHIAT, V172, P1075, DOI 10.1176/appi.ajp.2015.15020152
   Knott C, 2015, DIABETES CARE, V38, P1804, DOI 10.2337/dc15-0710
   Kodavanti UP, 2016, BBA-GEN SUBJECTS, V1860, P2880, DOI 10.1016/j.bbagen.2016.05.010
   Kolb H, 2010, DIABETOLOGIA, V53, P10, DOI 10.1007/s00125-009-1573-7
   Kolb H, 2012, NAT REV ENDOCRINOL, V8, P183, DOI 10.1038/nrendo.2011.158
   Korner J, 2007, SURG OBES RELAT DIS, V3, P597, DOI 10.1016/j.soard.2007.08.004
   Kowall B, 2016, SLEEP MED, V21, P35, DOI 10.1016/j.sleep.2015.12.017
   Kruyt ND, 2012, DIABETES TECHNOL THE, V14, P311, DOI 10.1089/dia.2011.0171
   Kuwabara M, 2017, J CARDIOL, V70, P107, DOI 10.1016/j.jjcc.2016.10.008
   Lanki T, 2015, ENVIRON HEALTH PERSP, V123, P785, DOI 10.1289/ehp.1408224
   Lao XQ, 2015, INT J OBESITY, V39, P288, DOI 10.1038/ijo.2014.95
   Leng Y, 2016, NUTR METAB CARDIOVAS, V26, P996, DOI 10.1016/j.numecd.2016.06.006
   Leong A, 2014, BMC MED, V12, DOI 10.1186/1741-7015-12-12
   Levine JA, 2000, AM J CLIN NUTR, V72, P1451
   Levine JA, 2015, DIABETOLOGIA, V58, P1751, DOI 10.1007/s00125-015-3624-6
   Li T, 2015, FREE RADICAL RES, V49, P1269, DOI 10.3109/10715762.2015.1066784
   Li XH, 2016, AM J CLIN NUTR, V103, P818, DOI 10.3945/ajcn.115.114389
   Li YP, 2016, DIABETOLOGIA, V59, P719, DOI 10.1007/s00125-015-3860-9
   Lim EL, 2011, DIABETOLOGIA, V54, P2506, DOI 10.1007/s00125-011-2204-7
   Lindström J, 2013, DIABETOLOGIA, V56, P284, DOI 10.1007/s00125-012-2752-5
   Lips MA, 2014, DIABETES CARE, V37, P3150, DOI 10.2337/dc14-0195
   Lips MA, 2014, CLIN ENDOCRINOL, V81, P862, DOI 10.1111/cen.12496
   Lips MA, 2014, CLIN ENDOCRINOL, V80, P834, DOI 10.1111/cen.12254
   Loef M, 2012, PREV MED, V55, P163, DOI 10.1016/j.ypmed.2012.06.017
   Löfvenborg JE, 2016, EUR J ENDOCRINOL, V175, P605, DOI 10.1530/EJE-16-0376
   Longo VD, 2014, CELL METAB, V19, P181, DOI 10.1016/j.cmet.2013.12.008
   López-Lluch G, 2016, J PHYSIOL-LONDON, V594, P2043, DOI 10.1113/JP270543
   Ma RCW, 2013, ANN NY ACAD SCI, V1281, P64, DOI 10.1111/nyas.12098
   Ma Y, 2016, LANCET DIABETES ENDO, V4, P105, DOI 10.1016/S2213-8587(15)00477-5
   de Rezende LFM, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-333
   Maffei A, 2015, MOL ENDOCRINOL, V29, P542, DOI 10.1210/me.2014-1273
   Maki KC, 2015, J NUTR, V145, P159, DOI 10.3945/jn.114.195149
   Malandrucco I, 2012, AM J CLIN NUTR, V95, P609, DOI 10.3945/ajcn.111.023697
   Mariño G, 2014, AUTOPHAGY, V10, P1879, DOI 10.4161/auto.36413
   Martinez-Gomez D, 2012, J PEDIATR-US, V160, P104, DOI 10.1016/j.jpeds.2011.06.037
   Martinussen C, 2015, AM J PHYSIOL-ENDOC M, V308, pE535, DOI 10.1152/ajpendo.00506.2014
   McNelis JC, 2014, IMMUNITY, V41, P36, DOI 10.1016/j.immuni.2014.05.010
   Meisinger C, 2009, PSYCHOSOM MED, V71, P784, DOI 10.1097/PSY.0b013e3181ae5770
   Melamed S, 2006, PSYCHOSOM MED, V68, P863, DOI 10.1097/01.psy.0000242860.24009.f0
   Miedema Henk M E, 2007, Behav Sleep Med, V5, P1, DOI 10.1207/s15402010bsm0501_1
   Miele L, 2009, HEPATOLOGY, V49, P1877, DOI 10.1002/hep.22848
   Moisey LL, 2008, AM J CLIN NUTR, V87, P1254, DOI 10.1093/ajcn/87.5.1254
   Nannipieri M, 2011, J CLIN ENDOCR METAB, V96, pE1372, DOI 10.1210/jc.2011-0446
   Nathan DM, 2015, LANCET DIABETES ENDO, V3, P866, DOI 10.1016/S2213-8587(15)00291-0
   Neeland IJ, 2012, JAMA-J AM MED ASSOC, V308, P1150, DOI 10.1001/2012.jama.11132
   Negro F, 2014, J HEPATOL, V61, pS69, DOI 10.1016/j.jhep.2014.08.003
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Nguyen KT, 2014, CURR DIABETES REP, V14, DOI 10.1007/s11892-014-0481-5
   Novak M, 2013, DIABETIC MED, V30, pE8, DOI 10.1111/dme.12037
   Ohnaka K, 2012, J NUTR METAB, V2012, DOI 10.1155/2012/207426
   Pall Martin L., 2015, Shengli Xuebao, V67, P1
   Pan A, 2015, LANCET DIABETES ENDO, V3, P958, DOI 10.1016/S2213-8587(15)00316-2
   Parker L, 2017, FRONT PHYSIOL, V7, DOI 10.3389/fphys.2016.00661
   Pasarica M, 2006, OBESITY, V14, P1905, DOI 10.1038/oby.2006.222
   Peinado JR, 2014, PROTEOMICS, V14, P452, DOI 10.1002/pmic.201300376
   Phillips CM, 2013, REV ENDOCR METAB DIS, V14, P219, DOI 10.1007/s11154-013-9252-x
   Polyzogopoulou EV, 2003, DIABETES, V52, P1098, DOI 10.2337/diabetes.52.5.1098
   Pouwer F, 2010, DISCOV MED, V9, P112
   Priyadarshini M, 2016, TRENDS ENDOCRIN MET, V27, P653, DOI 10.1016/j.tem.2016.03.011
   Qin S, 2016, MOL NUTR FOOD RES, V60, P1731, DOI 10.1002/mnfr.201501017
   Rakvaag E, 2016, EUR J NUTR, V55, P2221, DOI 10.1007/s00394-015-1032-9
   Rao MN, 2015, J CLIN ENDOCR METAB, V100, P1664, DOI 10.1210/jc.2014-3911
   Reynolds AC, 2010, PROG BRAIN RES, V185, P91, DOI 10.1016/B978-0-444-53702-7.00006-3
   Roberson LL, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-14
   Robertson TM, 2015, BRIT J NUTR, V114, P1218, DOI 10.1017/S0007114515002640
   Rockette-Wagner B, 2015, DIABETOLOGIA, V58, P1198, DOI 10.1007/s00125-015-3565-0
   Rodieux F, 2008, OBESITY, V16, P298, DOI 10.1038/oby.2007.83
   Rodriguez AR, 2015, CELL IMMUNOL, V295, P83, DOI 10.1016/j.cellimm.2015.03.010
   Rodriguez-Ramiro I, 2016, P NUTR SOC, V75, P47, DOI 10.1017/S0029665115004218
   Rutters F, 2015, STRESS, V18, P507, DOI 10.3109/10253890.2015.1064891
   Sacerdote C, 2012, INT J EPIDEMIOL, V41, P1162, DOI 10.1093/ije/dys091
   Salas-Salvadó J, 2011, DIABETES CARE, V34, P14, DOI 10.2337/dc10-1288
   Satija A, 2016, PLOS MED, V13, DOI 10.1371/journal.pmed.1002039
   Sattar N, 2014, BMC MED, V12, DOI 10.1186/s12916-014-0123-4
   Schwingshackl L, 2017, EUR J EPIDEMIOL, V32, P363, DOI 10.1007/s10654-017-0246-y
   Shadyab AH, 2015, AGEING RES REV, V19, P1, DOI 10.1016/j.arr.2014.10.005
   Shan ZL, 2015, DIABETES CARE, V38, P529, DOI 10.2337/dc14-2073
   Shen XM, 2015, MOL CELL ENDOCRINOL, V412, P1, DOI 10.1016/j.mce.2015.05.014
   Sjöholm K, 2016, DIABETES CARE, V39, P625, DOI 10.2337/dc15-1407
   Smith AD, 2016, DIABETOLOGIA, V59, P2527, DOI 10.1007/s00125-016-4079-0
   Sommer I, 2015, BMC PUBLIC HEALTH, V15, DOI 10.1186/s12889-015-2227-y
   Sorensen M, 2013, ENVIRON HEALTH PERSP, V121, P217, DOI 10.1289/ehp.1205503
   Souza AD, 2015, CURR TOP BEHAV NEURO, V25, P65, DOI 10.1007/7854_2014_360
   Stefanson AL, 2014, NUTRIENTS, V6, P3777, DOI 10.3390/nu6093777
   Stringhini S, 2016, SCI REP-UK, V6, DOI 10.1038/srep24780
   Supale S, 2012, TRENDS ENDOCRIN MET, V23, P477, DOI 10.1016/j.tem.2012.06.002
   Svendsen PF, 2012, SCAND J CLIN LAB INV, V72, P410, DOI 10.3109/00365513.2012.691542
   Swerdlow DI, 2016, CARDIOVASC DRUG THER, V30, P51, DOI 10.1007/s10557-016-6638-5
   Tay J, 2014, DIABETES CARE, V37, P2909, DOI 10.2337/dc14-0845
   Thorand B, 2006, ATHEROSCLEROSIS, V184, P216, DOI 10.1016/j.atherosclerosis.2005.04.011
   Tobias DK, 2015, LANCET DIABETES ENDO, V3, P968, DOI 10.1016/S2213-8587(15)00367-8
   Tuomilehto Jaakko, 2001, New England Journal of Medicine, V344, P1343, DOI 10.1056/NEJM200105033441801
   Unnikrishnan R, 2014, DIABETES, V63, P53, DOI 10.2337/db13-1592
   Valenti L, 2016, LIVER INT, V36, P1563, DOI 10.1111/liv.13185
   Vasto S, 2014, GERONTOLOGY, V60, P508, DOI 10.1159/000363060
   Virtanen M, 2014, DIABETES CARE, V37, P2091, DOI 10.2337/dc13-2725
   Wang M, 2015, J DIABETES INVEST, V6, P360, DOI 10.1111/jdi.12309
   Wang YF, 2005, AM J CLIN NUTR, V81, P555
   Wedick NM, 2011, NUTR J, V10, DOI 10.1186/1475-2891-10-93
   Weinmayr G, 2015, ENVIRON HEALTH-GLOB, V14, DOI 10.1186/s12940-015-0031-x
   Willcox DC, 2014, MECH AGEING DEV, V136, P148, DOI 10.1016/j.mad.2014.01.002
   Willi C, 2007, JAMA-J AM MED ASSOC, V298, P2654, DOI 10.1001/jama.298.22.2654
   Williams ED, 2010, DIABETOLOGIA, V53, P2538, DOI 10.1007/s00125-010-1888-4
   Xi B, 2014, SLEEP MED REV, V18, P293, DOI 10.1016/j.smrv.2013.06.001
   Xiao SM, 2014, FEMS MICROBIOL ECOL, V87, P357, DOI 10.1111/1574-6941.12228
   Yancy WS Jr, 2015, ANN INTERN MED, V162, P805, DOI 10.7326/M14-2358
   Yang J, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2014-005632
   Yang WS, 2014, BRIT J NUTR, V111, P1329, DOI 10.1017/S0007114513003887
   Yates T, 2015, PREV MED, V76, P79, DOI 10.1016/j.ypmed.2015.04.005
   You TJ, 2013, SPORTS MED, V43, P243, DOI 10.1007/s40279-013-0023-3
   Zhang LX, 2011, DIABETES CARE, V34, P892, DOI 10.2337/dc10-2087
   Zheng XX, 2013, AM J CLIN NUTR, V97, P750, DOI 10.3945/ajcn.111.032573
   Zhou B, 2016, LANCET, V387, P1513, DOI 10.1016/S0140-6736(16)00618-8
   Zong G, 2016, PLOS MED, V13, DOI 10.1371/journal.pmed.1002052
NR 193
TC 462
Z9 520
U1 9
U2 183
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1741-7015
J9 BMC MED
JI BMC Med.
PD JUL 19
PY 2017
VL 15
AR 131
DI 10.1186/s12916-017-0901-x
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FA8LC
UT WOS:000405696500001
PM 28720102
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Buckingham, JC
AF Buckingham, JC
TI Glucocorticoids: exemplars of multi-tasking
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE glucocorticoids; HPA axis; glucocorticoid receptors
ID RECEPTOR; CORTICOSTERONE; PITUITARY; CORTISOL; STRESS; CORTICOTROPIN;
   ANNEXIN-1; RESPONSES; HORMONE; MICE
AB Well over 80 years ago Philip Smith described the beneficial clinical effects of adrenocortical extracts in animal models of adrenal insufficiency. In the ensuing years, scientists across the globe have sought to understand the mechanisms by which adrenal hormones and their synthetic analogues produce their complex and varied actions. Particular attention has focused on the glucocorticoids, partly because they have a vital place in the treatment of inflammatory and autoimmune disorders but also because dysregulation of the secretion and/or activity of endogenous glucocorticoids is increasingly implicated in a number of common disorders that pose a growing clinical burden, such as obesity, type II diabetes, the metabolic syndrome, hypertension and depression. This review considers some of the key advances that have been made in Our understanding of the physiology, pathology and pharmacology of the glucocorticoids. Emphasis is placed on the molecular mechanisms of glucocorticoid signalling and the complex mechanisins that regulate the access of steroids in the systemic circulation to their receptors in their various target cells and tissues. In addition, consideration is given to the irreversible 4 organisational' actions of glucocorticoids in perinatal life and to the potential role of the steroids in the aetiology of disease.
C1 Univ London Imperial Coll Sci Technol & Med, Div Neurosci & Mental Hlth, Dept Cellular & Mol Neurosci, London W12 0NN, England.
C3 Imperial College London
RP Univ London Imperial Coll Sci Technol & Med, Div Neurosci & Mental Hlth, Dept Cellular & Mol Neurosci, London W12 0NN, England.
EM j.buckingham@imperial.ac.uk
FU Biotechnology and Biological Sciences Research Council [BB/E52708X/1]
   Funding Source: Medline
CR BARKER DJP, 1989, BMJ-BRIT MED J, V298, P564, DOI 10.1136/bmj.298.6673.564
   Barnes PJ, 2003, ANN INTERN MED, V139, P359, DOI 10.7326/0003-4819-139-5_Part_1-200309020-00012
   BEATO M, 1995, CELL, V83, P851, DOI 10.1016/0092-8674(95)90201-5
   BENESOVA O, 1989, NEUROPHARMACOLOGY, V28, P89, DOI 10.1016/0028-3908(89)90073-7
   Brown SD, 1996, J CRIT CARE, V11, P2, DOI 10.1016/S0883-9441(96)90014-3
   BUCKINGHAM JC, 1974, J ENDOCRINOL, V63, P213, DOI 10.1677/joe.0.0630213
   Buckingham JC, 1997, DEV BRAIN DYSFUNCT, V10, P482
   Chapman L, 2002, ENDOCRINOLOGY, V143, P4330, DOI 10.1210/en.2002-220529
   Croxtall JD, 2003, BIOCHEM J, V371, P927, DOI 10.1042/BJ20021856
   De Kloet ER, 1998, ENDOCR REV, V19, P269, DOI 10.1210/er.19.3.269
   Diaz R, 1997, NEUROSCIENCE, V81, P129, DOI 10.1016/S0306-4522(97)00141-3
   Draper N, 2003, NAT GENET, V34, P434, DOI 10.1038/ng1214
   Edwards CRW, 1996, STEROIDS, V61, P263, DOI 10.1016/0039-128X(96)00033-5
   FLOWER RJ, 1979, NATURE, V278, P456, DOI 10.1038/278456a0
   Funder JW, 2005, HEART FAIL REV, V10, P15, DOI 10.1007/s10741-005-2344-2
   Gold PW, 2002, BIOL PSYCHIAT, V52, P381, DOI 10.1016/S0006-3223(02)01480-4
   Goulding NJ, 2004, CURR OPIN PHARMACOL, V4, P629, DOI 10.1016/j.coph.2004.06.009
   Hannon R, 2002, FASEB J, V16, P253, DOI 10.1096/fj.02-0239fje
   John CD, 2004, TRENDS ENDOCRIN MET, V15, P103, DOI 10.1016/j.tem.2004.02.001
   Kofman O, 2002, NEUROSCI BIOBEHAV R, V26, P457, DOI 10.1016/S0149-7634(02)00015-5
   Kotelevtsev Y, 1999, J CLIN INVEST, V103, P683, DOI 10.1172/JCI4445
   Maier C, 2005, J CELL SCI, V118, P3353, DOI 10.1242/jcs.02462
   Meijer OC, 2003, J ENDOCRINOL, V178, P13, DOI 10.1677/joe.0.1780013
   Müller MB, 2004, NEUROENDOCRINOLOGY, V79, P1, DOI 10.1159/000076041
   MUNCK A, 1992, MOL CELL ENDOCRINOL, V90, pC1, DOI 10.1016/0303-7207(92)90091-J
   MURPHY BEP, 2002, ENCY STRESS, P244
   O'Regan D, 2004, AM J PHYSIOL-ENDOC M, V287, pE863, DOI 10.1152/ajpendo.00137.2004
   OLTON DS, 1975, DEV PSYCHOBIOL, V8, P55, DOI 10.1002/dev.420080108
   Pariante CM, 2004, PSYCHONEUROENDOCRINO, V29, P423, DOI 10.1016/j.psyneuen.2003.10.009
   Perretti M, 2003, TRENDS PHARMACOL SCI, V24, P574, DOI 10.1016/j.tips.2003.09.010
   Reichardt HM, 1998, CELL, V93, P531, DOI 10.1016/S0092-8674(00)81183-6
   Ridder S, 2005, J NEUROSCI, V25, P6243, DOI 10.1523/JNEUROSCI.0736-05.2005
   Sapolsky RM, 2000, ENDOCR REV, V21, P55, DOI 10.1210/er.21.1.55
   SECKL JR, 2004, EUR J ENDOCRINOL S3, V4, P597
   Stevens A, 2004, CLIN ENDOCRINOL, V61, P327, DOI 10.1111/j.1365-2265.2004.02097.x
   STEWART PM, 1988, J CLIN INVEST, V82, P340, DOI 10.1172/JCI113592
   Wintermantel TA, 2005, J STEROID BIOCHEM, V93, P107, DOI 10.1016/j.jsbmb.2004.12.033
NR 37
TC 196
Z9 251
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD JAN
PY 2006
VL 147
SU 1
BP S258
EP S268
DI 10.1038/sj.bjp.0706456
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 009BZ
UT WOS:000235087400030
PM 16402112
OA Green Published
DA 2025-06-11
ER

PT J
AU Ahmadnezhad, M
   Arefhosseini, SR
   Parizadeh, MR
   Tavallaie, S
   Tayefi, M
   Darroudi, S
   Ghazizadeh, H
   Moohebati, M
   Ebrahimi, M
   Heidari-Bakavoli, A
   Azarpajouh, MR
   Ferns, GA
   Mogharebzadeh, V
   Ghayour-Mobarhan, M
AF Ahmadnezhad, Mahsa
   Arefhosseini, Seyed Rafie
   Parizadeh, Mohammad Reza
   Tavallaie, Shima
   Tayefi, Maryam
   Darroudi, Susan
   Ghazizadeh, Hamideh
   Moohebati, Mohsen
   Ebrahimi, Mahmoud
   Heidari-Bakavoli, Alireza
   Azarpajouh, Mahmoud Reza
   Ferns, Gordon A.
   Mogharebzadeh, Vahid
   Ghayour-Mobarhan, Majid
TI Association between serum uric acid, high sensitive C-reactive protein
   and pro-oxidant-antioxidant balance in patients with metabolic syndrome
SO BIOFACTORS
LA English
DT Article
DE pro-oxidant; antioxidant; PAB; metabolic syndrome; hs-CRP; uric acid
ID OXIDATIVE STRESS MARKERS; RISK-FACTORS; INSULIN-RESISTANCE; IKK-BETA;
   VITAMIN; DISEASE; INFLAMMATION; POPULATION; OBESITY; IMPACT
AB There is persuasive evidence that oxidative stress and inflammation are features of the metabolic syndrome (MetS). We have investigated the relationship between serum pro-oxidant-antioxidant balance (PAB), serum uric acid, and high sensitive C-reactive protein (hs-CRP) in 7,208 participants from the MASHAD study cohort, who were categorized as having MetS, or not, using International Diabetes Foundation (IDF) criteria. Serum hs-CRP was measured by Polyethylene glycol (PEG)-enhanced immunoturbidimetry method using an Alycon analyzer (ABBOTT, Chicago, IL, USA). A colorimetric method was used to determine serum PAB. Serum PAB values were significantly higher in the individuals with MetS compared to those without (P<0.001). Furthermore, there was a step-wise increase in mean serum PAB concentrations as the number of components of the MetS increased. The combination of features of MetS had different association with serum PAB and hs-CRP. Multiple linear regression analysis showed that body mass index (BMI, B=2.04, P<0.001), physical activity level (PAL, B=18.728, P=0.001), serum uric acid (B=-1.545, P=0.003), and serum C-reactive protein (B=0.663, P<0.001) were associated with serum PAB in individuals with MetS. Multiple logistic regression analysis showed that serum PAB (B=0.002, P<0.001, CI=1.001-1.003), serum C-reactive protein (B=0.007, P< 0.015, CI=1.001-1.013), and serum uric acid (B=0.207, P<0.001, CI=1.186-1.277) were all significantly associated with MetS. Serum PAB was strongly associated with serum uric acid and serum hs-CRP. Moreover, serum PAB as well as serum uric acid and serum hs-CRP were independently associated with MetS. Individual features of MetS were also associated with serum hs-CRP and PAB. (c) 2018 BioFactors, 44(3):263-271, 2018
C1 [Ahmadnezhad, Mahsa] Tabriz Univ Med Sci, Dept Community Nutr, Nutr Res Ctr, Tabriz, Iran.
   [Ahmadnezhad, Mahsa] Mashhad Univ Med Sci, Student Res Comm, Fac Med, Mashhad, Iran.
   [Arefhosseini, Seyed Rafie] Tabriz Univ Med Sci, Dept Nutr Biochem, Tabriz, Iran.
   [Parizadeh, Mohammad Reza; Tavallaie, Shima; Tayefi, Maryam; Darroudi, Susan; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Fac Med, Mashhad, Iran.
   [Ghazizadeh, Hamideh] Mashhad Univ Med Sci, Sch Med, Dept Modern Sci & Technol, Mol Med Grp, Mashhad, Iran.
   [Moohebati, Mohsen; Ebrahimi, Mahmoud; Heidari-Bakavoli, Alireza; Azarpajouh, Mahmoud Reza] Mashhad Univ Med Sci, Cardiovasc Res Ctr, Fac Med, Mashhad, Iran.
   [Ferns, Gordon A.] Brighton & Sussex Med Sch, Div Med Educ, Brighton BN1 9PH, Sussex, England.
   [Mogharebzadeh, Vahid] Mazandaran Univ Med Sci, Fac Hlth, Dept Biostat, Sari, Iran.
C3 Tabriz University of Medical Science; Mashhad University of Medical
   Sciences; Tabriz University of Medical Science; Mashhad University of
   Medical Sciences; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences; University of Brighton; University of
   Sussex; Mazandaran University of Medical Sciences
RP Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Fac Med, Mashhad, Iran.; Arefhosseini, SR (corresponding author), Sch Nutr & Food Sci, Nutr Biochem, Tabriz, Iran.
EM arefhosseini@gmail.com; ghayourm@mums.ac.ir
RI Ghayour-Mobarhan, Majid/AAY-5963-2020; Ghazizadeh,
   Hamideh/ABE-8941-2020; Ebrahimi, Mehrzad/AAO-9791-2021; mohebati,
   mohsen/AAR-2016-2021
OI tayefi, maryam/0000-0003-4637-7754
FU Tabriz University of Medical Science; Mashhad University of Medical
   Sciences
FX This study was support by grant from Tabriz University of Medical
   Science and Mashhad University of Medical Sciences.
CR Alamdari DH, 2008, CLIN BIOCHEM, V41, P375, DOI 10.1016/j.clinbiochem.2007.12.008
   Alamdari DH, 2007, CLIN BIOCHEM, V40, P248, DOI 10.1016/j.clinbiochem.2006.10.017
   Alamdari DH, 2009, IRAN J BASIC MED SCI, V12, P93
   Alvarez-Lario B, 2011, QJM-INT J MED, V104, P1015, DOI 10.1093/qjmed/hcr159
   Arkan MC, 2005, NAT MED, V11, P191, DOI 10.1038/nm1185
   Carocho M, 2013, FOOD CHEM TOXICOL, V51, P15, DOI 10.1016/j.fct.2012.09.021
   Donath MY, 2011, NAT REV IMMUNOL, V11, P98, DOI 10.1038/nri2925
   Dröge W, 2002, PHYSIOL REV, V82, P47, DOI 10.1152/physrev.00018.2001
   Fadini GP, 2008, EUR J CARDIOV PREV R, V15, P190, DOI 10.1097/HJR.0b013e3282f17bc3
   Fadini GP, 2010, ATHEROSCLEROSIS, V210, P45, DOI 10.1016/j.atherosclerosis.2010.02.021
   Finkel T, 2000, NATURE, V408, P239, DOI 10.1038/35041687
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Guallar E, 2013, ANN INTERN MED, V159, P850, DOI 10.7326/0003-4819-159-12-201312170-00011
   Huang ZY, 2017, CELL COMMUN SIGNAL, V15, DOI 10.1186/s12964-016-0158-6
   Kang DH, 2005, J AM SOC NEPHROL, V16, P3553, DOI 10.1681/ASN.2005050572
   Kelishadi R, 2007, CLIN CHEM, V53, P456, DOI 10.1373/clinchem.2006.073668
   Korkmaz GG, 2013, METABOLISM, V62, P828, DOI 10.1016/j.metabol.2013.01.002
   Liou Teh-Ling, 2006, J Chin Med Assoc, V69, P104, DOI 10.1016/S1726-4901(09)70186-8
   Maeda S, 2003, IMMUNITY, V19, P725, DOI 10.1016/S1074-7613(03)00301-7
   Mataix J, 1998, FREE RADICAL BIO MED, V24, P511, DOI 10.1016/S0891-5849(97)00288-8
   Nathan C, 2010, CELL, V140, DOI 10.1016/j.cell.2010.03.008
   Palmieri VO, 2006, J NUTR, V136, P3022, DOI 10.1093/jn/136.12.3022
   Papezíková I, 2013, FREE RADICAL RES, V47, P82, DOI 10.3109/10715762.2012.747677
   Razavi A, 2013, CLIN LAB, V59, P257, DOI 10.7754/Clin.Lab.2012.120403
   Razavi A, 2013, ANN CLIN BIOCHEM, V50, P115, DOI 10.1258/acb.2012.012104
   Rehman K, 2016, J BIOMED SCI, V23, DOI 10.1186/s12929-016-0303-y
   Reimann MA, 2008, ATHEROSCLEROSIS, V197, P638, DOI 10.1016/j.atherosclerosis.2007.09.011
   Ren XM, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-017-0531-9
   Russell JW, 2002, FASEB J, V16, P1738, DOI 10.1096/fj.01-1027com
   Schwedler S, 2001, KIDNEY INT, V59, pS32, DOI 10.1046/j.1523-1755.2001.59780032.x
   Sies H, 1997, EXP PHYSIOL, V82, P291, DOI 10.1113/expphysiol.1997.sp004024
   Trotti R, 2001, HAEMATOLOGICA, V86, P85
   Uttara B, 2009, CURR NEUROPHARMACOL, V7, P65, DOI 10.2174/157015909787602823
   Yang HK, 2015, DIABETES METAB, V41, P282, DOI 10.1016/j.diabet.2015.03.005
   Young AJ, 2001, ARCH BIOCHEM BIOPHYS, V385, P20, DOI 10.1006/abbi.2000.2149
NR 35
TC 26
Z9 27
U1 1
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-6433
EI 1872-8081
J9 BIOFACTORS
JI Biofactors
PD MAY-JUN
PY 2018
VL 44
IS 3
BP 263
EP 271
DI 10.1002/biof.1424
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA GK0BO
UT WOS:000435770800007
PM 29638023
DA 2025-06-11
ER

PT J
AU Khlifi, R
   Dhaouefi, Z
   Ben Toumia, I
   Lahmar, A
   Sioud, F
   Bouhajeb, R
   Bellalah, A
   Chekir-Ghedira, L
AF Khlifi, Rihab
   Dhaouefi, Zaineb
   Ben Toumia, Imene
   Lahmar, Aida
   Sioud, Fairouz
   Bouhajeb, Rim
   Bellalah, Ahlem
   Chekir-Ghedira, Leila
TI Erica multiflora extract rich in quercetin-3-O-glucoside and
   kaempferol-3-O-glucoside alleviates high fat and fructose diet-induced
   fatty liver disease by modulating metabolic and inflammatory pathways in
   Wistar rats
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Erica multiflora; LC-MS/MS; High-fat-fructose diet; Metabolic syndrome;
   Oxidative stress; Inflammation
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; ANTIOXIDANT ACTIVITY;
   NITRIC-OXIDE; IN-VITRO; QUERCETIN; ACID; HYPERLIPIDEMIA; FLAVONOIDS;
   STEATOSIS
AB The wide morbidity of obesity has heightened interest in providing natural and safe compounds to maintain optimal health. The present study was designed to determine the chemical constituents and the effects of methanol leaf extract from Erica multiflora (M-EML) on mitigating high-fat and high-fructose diet (HFFD)-induced metabolic syndrome (MS).
   LC-MS/MS characterization of M-EML allowed the identification of 14 secondary metabolites and showed that quercetin-3-O-glucoside and kaempferol-3-O-glucoside were the main compounds of our extract. In the in vivo study, the oral administration of M-EML (250 mg/kg) during the last 4 weeks of the experimentation alleviated HFFD-induced obesity, insulin resistance (IR) and cardiovascular diseases. Thus, M-EML treatment significantly normalized body and liver weight, allowed to a sharp decline in plasma levels of TC, TG and LDL-c by 32%, 35% and 66%, respectively. Moreover, hepatic enzymes, total and direct bilirubin, lipase and uric acid levels have been diminished in treated group. Histopathology of the liver confirmed the changes induced by HFFD and the hepatoprotective effect of M-EML. The supply of M-EML reduced NO production and cellular lysosomal enzyme activity by 44% and 60%, respectively compared to HFFD. Besides, M-EML showed decreased pro-inflammatory cytokines levels (259.5 +/- 47.35 pg/ml and 56.08 +/- 1.56 pg/ml) of TNF-alpha and IL-6, respectively.
   In addition, M-EML reduced liver malondialdehyde (MDA) content and enhanced superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities. In contrast, these enzymatic activities have been disrupted in HFFD rats.
   Overall, M-EML prevented obesity through the modulation of metabolic syndrome, reducing inflammation and promoting antioxidant enzymes activities. (C) 2020 Elsevier Inc. All rights reserved.
C1 [Khlifi, Rihab; Dhaouefi, Zaineb; Ben Toumia, Imene; Lahmar, Aida; Sioud, Fairouz; Bouhajeb, Rim; Chekir-Ghedira, Leila] Univ Monastir, Fac Dent Med, Unity Bioact & Nat Subst & Biotechnol UR17ES49, Avicenna St, Monastir 5000, Tunisia.
   [Khlifi, Rihab] Higher Inst Biotechnol Monastir, Ave Tahar Hadded,BP 74, Monastir 5000, Tunisia.
   [Ben Toumia, Imene; Sioud, Fairouz; Bouhajeb, Rim] Univ Monastir, Fac Pharm, Avicenna St, Monastir 5000, Tunisia.
   [Bellalah, Ahlem] Fattouma Bourguiba Univ Hosp, Dept Pathol, Monastir, Tunisia.
C3 Universite de Monastir; Universite de Monastir; Universite de Monastir;
   Universite de Monastir; Hopital Fattouma Bourguiba
RP Khlifi, R (corresponding author), Univ Monastir, Fac Dent Med, Unity Bioact & Nat Subst & Biotechnol UR17ES49, Avicenna St, Monastir 5000, Tunisia.
EM rihabkhlifi@gmail.com
OI dhaouefi, zaineb/0000-0002-2004-0953
FU Ministry of Higher Education, Scientific Research and Technology,
   Tunisia
FX We acknowledge the "Ministry of Higher Education, Scientific Research
   and Technology, Tunisia", for the support of this study.
CR Adiga S., 2019, INT J GREEN PHARM IJ, P13
   Akaberi M, 2016, PHYTOTHER RES, V30, P540, DOI 10.1002/ptr.5570
   AL-Ishaq RK, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9090430
   [Anonymous], 1984, METHOD ENZYMOL
   Attia RT, 2019, BIOMED PHARMACOTHER, V110, P500, DOI 10.1016/j.biopha.2018.11.079
   Boukef M.K., 1986, PLANTES MED TRADITIO
   CAREVIC O, 1988, AGENTS ACTIONS, V25, P124, DOI 10.1007/BF01969103
   Casagrande BP, 2019, INFLAMM RES, V68, P359, DOI 10.1007/s00011-019-01223-1
   Castro MC, 2020, J ETHNOPHARMACOL, V247, DOI 10.1016/j.jep.2019.112263
   Dower JI, 2015, AM J CLIN NUTR, V101, P914, DOI 10.3945/ajcn.114.098590
   Rubio-Ruiz ME, 2019, MOLECULES, V24, DOI 10.3390/molecules24071297
   Faudzi SMM, 2015, MEDCHEMCOMM, V6, P1069, DOI 10.1039/c4md00541d
   Feillet-Coudray C, 2019, LIPIDS, V54, P81, DOI 10.1002/lipd.12128
   Ferder L, 2010, CURR HYPERTENS REP, V12, P105, DOI 10.1007/s11906-010-0097-3
   Fraga CG, 2019, FOOD FUNCT, V10, P514, DOI [10.1039/c8fo01997e, 10.1039/C8FO01997E]
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   GREEN LC, 1982, ANAL BIOCHEM, V126, P131, DOI 10.1016/0003-2697(82)90118-X
   Gu Z, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0927-x
   Guendouze-Bouchefa N, 2015, IND CROP PROD, V70, P459, DOI 10.1016/j.indcrop.2015.03.053
   Guo XX, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071697
   HARBORNE JB, 1973, BOT J LINN SOC, V66, P37, DOI 10.1111/j.1095-8339.1973.tb02159.x
   Harnafi H, 2007, J ETHNOPHARMACOL, V109, P156, DOI 10.1016/j.jep.2006.09.017
   HAVSTEEN B, 1983, BIOCHEM PHARMACOL, V32, P1141, DOI 10.1016/0006-2952(83)90262-9
   Ibrahim SM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0117516
   Jayachandran M, 2019, CHEM-BIOL INTERACT, V303, P62, DOI 10.1016/j.cbi.2019.02.017
   Juonala M, 2020, INT J OBESITY, V44, P82, DOI 10.1038/s41366-019-0457-2
   Kalaivani A, 2019, ARCH PHYSIOL BIOCHEM, V125, P228, DOI 10.1080/13813455.2018.1452036
   Kamada C, 2005, FREE RADICAL RES, V39, P185, DOI 10.1080/10715760400019638
   Kawano M, 2009, J NAT MED-TOKYO, V63, P335, DOI 10.1007/s11418-009-0324-x
   Khlifi R, 2019, REGUL TOXICOL PHARM, V107, DOI 10.1016/j.yrtph.2019.104404
   Khlifi R, 2018, INT IMMUNOPHARMACOL, V61, P317, DOI 10.1016/j.intimp.2018.06.010
   Kilani-Jaziri S, 2016, TUMOR BIOL, V37, P6571, DOI 10.1007/s13277-015-4541-5
   Kobori M, 2009, MOL NUTR FOOD RES, V53, P859, DOI 10.1002/mnfr.200800310
   Krisnamurti DGB, 2019, AIP CONF PROC, V2193, DOI 10.1063/1.5139351
   Kristinová V, 2009, J AGR FOOD CHEM, V57, P10377, DOI 10.1021/jf901072t
   Kuate D, 2015, LIPIDS HEALTH DIS, V14, DOI 10.1186/s12944-015-0051-0
   Leclercq IA, 2007, J HEPATOL, V47, P142, DOI 10.1016/j.jhep.2007.04.002
   Li S, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/4234061
   Liu CM, 2017, NUTRIENTS, V9, DOI 10.3390/nu9090959
   Liu SS, 2018, BBA-MOL BASIS DIS, V1864, P3257, DOI 10.1016/j.bbadis.2018.07.012
   Maatouk M, 2016, CELL STRESS CHAPERON, V21, P1101, DOI 10.1007/s12192-016-0734-0
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McConell GK, 2008, CLIN EXP PHARMACOL P, V35, P1488, DOI 10.1111/j.1440-1681.2008.05038.x
   Hoang MH, 2015, J NUTR BIOCHEM, V26, P868, DOI 10.1016/j.jnutbio.2015.03.005
   Mokdad-Bzeouich I, 2016, CELL STRESS CHAPERON, V21, P773, DOI 10.1007/s12192-016-0702-8
   Muthulakshmi S, 2013, MOL CELL BIOCHEM, V377, P23, DOI 10.1007/s11010-013-1566-1
   Nasri R, 2018, RSC ADV, V8, P9383, DOI 10.1039/c7ra13102j
   Nworu CS, 2010, IMMUNOPHARM IMMUNOT, V32, P28, DOI 10.3109/08923970903062587
   Ohashi T, 2018, FOOD CHEM TOXICOL, V118, P190, DOI 10.1016/j.fct.2018.05.006
   Oktay M, 2003, LEBENSM-WISS TECHNOL, V36, P263, DOI 10.1016/S0023-6438(02)00226-8
   Othman A.I., 2019, Clinical Phytoscience, V5, P48, DOI DOI 10.1186/S40816-019-0140-0
   Panchal SK, 2012, J NUTR, V142, P1026, DOI 10.3945/jn.111.157263
   Pavlovic DR, 2013, RIV ITAL SOSTANZE GR, V90, P255
   Perdicaro DJ, 2017, FOOD FUNCT, V8, P3501, DOI [10.1039/C7FO01062A, 10.1039/c7fo01062a]
   Porras D, 2017, FREE RADICAL BIO MED, V102, P188, DOI 10.1016/j.freeradbiomed.2016.11.037
   Pottier-Alapetite G., 1979, FLORE TUNISIE ANGIOS
   Rafiei H, 2018, J FUNCT FOODS, V44, P173, DOI 10.1016/j.jff.2018.02.033
   Rahman HA, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1640-4
   Rivera L, 2008, OBESITY, V16, P2081, DOI 10.1038/oby.2008.315
   Ross SA, 2004, CHEM REV, V104, P1255, DOI 10.1021/cr0204653
   ROTRUCK JT, 1973, SCIENCE, V179, P588, DOI 10.1126/science.179.4073.588
   Sadashiva S.A., 2014, ASIAN J BIOCH PHARM, V4, P2231
   Sadki C, 2017, PROG UROL, V27, P1058, DOI 10.1016/j.purol.2017.09.011
   Sami Khaza M., 2013, Karbala J Med, V6, P1506
   Shen YB, 2019, BIOMED PHARMACOTHER, V111, P579, DOI 10.1016/j.biopha.2018.12.074
   Sies H, 2017, REDOX BIOL, V11, P613, DOI 10.1016/j.redox.2016.12.035
   Sobrecases H, 2010, DIABETES METAB, V36, P244, DOI 10.1016/j.diabet.2010.03.003
   Stanhope KL, 2008, CURR OPIN LIPIDOL, V19, P16, DOI 10.1097/MOL.0b013e3282f2b24a
   Sun NN, 2016, MOLECULES, V21, DOI 10.3390/molecules21101351
   Tamer F, 2020, FOOD CHEM TOXICOL, V135, DOI 10.1016/j.fct.2019.110914
   Tappy L, 2018, J EXP BIOL, V221, DOI 10.1242/jeb.164202
   Tchoumtchoua J, 2014, TOXICOL REP, V1, P877, DOI 10.1016/j.toxrep.2014.10.003
   Thomas S, 2015, IRAN J MED SCI, V40, P45
   Tilg H, 2006, GASTROENTEROLOGY, V131, P934, DOI 10.1053/j.gastro.2006.05.054
   Tramontin ND, 2020, PHYTOTHER RES, V34, P1282, DOI 10.1002/ptr.6619
   Tsiaoussis J, 2019, TOXICOL LETT, V312, P72, DOI 10.1016/j.toxlet.2019.04.014
   Uno M, 2008, HEPATOLOGY, V48, P109, DOI 10.1002/hep.22338
   Villareal MO, 2013, PLANTA MED, V79, P236, DOI 10.1055/s-0032-1328189
   Wada T, 2010, ENDOCRINOLOGY, V151, P2040, DOI 10.1210/en.2009-0869
   Wang O, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0118135
   Wang S, 2018, BIOMED PHARMACOTHER, V108, P1181, DOI 10.1016/j.biopha.2018.09.150
   Woods A, 2017, CELL REP, V18, P3043, DOI 10.1016/j.celrep.2017.03.011
   Yun JW, 2010, PHYTOCHEMISTRY, V71, P1625, DOI 10.1016/j.phytochem.2010.07.011
   Yuruk AA, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0618-z
   Zaki SM, 2019, FOLIA MORPHOL, V78, P124, DOI 10.5603/FM.a2018.0063
   Zang YQ, 2015, FOOD FUNCT, V6, P834, DOI [10.1039/c4fo00844h, 10.1039/C4FO00844H]
   Zhang Y, 2020, FOOD RES INT, V128, DOI 10.1016/j.foodres.2019.108785
NR 87
TC 36
Z9 38
U1 2
U2 29
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD DEC
PY 2020
VL 86
AR 108490
DI 10.1016/j.jnutbio.2020.108490
PG 11
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA OP2IL
UT WOS:000587904600006
PM 32920086
DA 2025-06-11
ER

PT J
AU Walrabenstein, W
   Wagenaar, CA
   van de Put, M
   van der Leeden, M
   Gerritsen, M
   Twisk, JWR
   van der Esch, M
   van Middendorp, H
   Weijs, PJM
   Roorda, LD
   van Schaardenburg, D
AF Walrabenstein, Wendy
   Wagenaar, Carlijn A.
   van de Put, Marieke
   van der Leeden, Marike
   Gerritsen, Martijn
   Twisk, Jos W. R.
   van der Esch, Martin
   van Middendorp, Henriet
   Weijs, Peter J. M.
   Roorda, Leo D.
   van Schaardenburg, Dirkjan
TI A multidisciplinary lifestyle program for metabolic syndrome-associated
   osteoarthritis: the "Plants for Joints" randomized controlled trial
SO OSTEOARTHRITIS AND CARTILAGE
LA English
DT Article
DE Osteoarthritis"; Diet; Physical activity; Stress management; Metabolic
   syndrome
ID PATIENT-REPORTED OUTCOMES; FAT VEGAN DIET; KNEE OSTEOARTHRITIS; HIP
   OSTEOARTHRITIS; OBESE ADULTS; WEIGHT-LOSS; RISK; INFLAMMATION;
   OVERWEIGHT; MANAGEMENT
AB Objective: To determine the effectiveness of the "Plants for Joints" multidisciplinary lifestyle program in patients with metabolic syndrome-associated osteoarthritis (MSOA).Design: Patients with hip or knee MSOA were randomized to the intervention or control group. The intervention group followed a 16-week program in addition to usual care based on a whole food plant-based diet, physical activity, and stress management. The control group received usual care. The patient-reported Western Ontario and McMasters Universities Osteoarthritis Index (WOMAC) total score (range 0-96) was the primary outcome. Secondary outcomes included other patient-reported, anthropometric, and metabolic measures. An intention-to-treat analysis with a linear-mixed model adjusted for baseline values was used to analyze between-group differences.Results: Of the 66 people randomized, 64 completed the study. Participants (84% female) had a mean (SD) age of 63 (6) years and body mass index of 33 (5) kg/m2. After 16 weeks, the intervention group (n = 32) had a mean 11-point larger improvement in WOMAC-score (95% CI 6-16; p = 0.0001) compared to the control group. The intervention group also lost more weight (-5 kg), fat mass (-4 kg), and waist circumference (-6 cm) compared to the control group. Patient-Reported Outcomes Measurement Information System (PROMIS) fatigue, pain interference, C-reactive protein, hemoglobin A1c, fasting glucose, and low-density lipoproteins improved in the intervention versus the control group, while other PROMIS measures, blood pressure, high-density lipoproteins, and triglycerides did not differ significantly between the groups.Conclusion: The "Plants for Joints" lifestyle program reduced stiffness, relieved pain, and improved physical function in people with hip or knee MSOA compared to usual care.(c) 2023 The Authors. Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
C1 [Walrabenstein, Wendy; Wagenaar, Carlijn A.; van de Put, Marieke; van der Leeden, Marike; Gerritsen, Martijn; van der Esch, Martin; Roorda, Leo D.; van Schaardenburg, Dirkjan] Reade Ctr Rheumatol & Rehabil, Amsterdam, Netherlands.
   [Walrabenstein, Wendy; Wagenaar, Carlijn A.; van Schaardenburg, Dirkjan] Univ Amsterdam, Amsterdam UMC, Dept Clin Immunol & Rheumatol, Amsterdam, Netherlands.
   [Walrabenstein, Wendy; Wagenaar, Carlijn A.; Gerritsen, Martijn; van Schaardenburg, Dirkjan] Amsterdam Rheumatol & Immunol Ctr, Amsterdam, Netherlands.
   [Walrabenstein, Wendy] Amsterdam Univ Appl Sci, Ctr Expertise Urban Vital, Dept Nutr & Dietet, Amsterdam, Netherlands.
   [van der Leeden, Marike] Vrije Univ, Amsterdam UMC, Dept Rehabil Med, Amsterdam, Netherlands.
   [van der Leeden, Marike; Weijs, Peter J. M.] Amsterdam Movement Sci Res Inst, Amsterdam, Netherlands.
   [Twisk, Jos W. R.] Vrije Univ, Amsterdam UMC, Dept Epidemiol & Data Sci, Amsterdam, Netherlands.
   [van der Esch, Martin] Amsterdam Univ Appl Sci, Fac Hlth, Ctr Expertise Urban Vital, Amsterdam, Netherlands.
   [van Middendorp, Henriet] Leiden Univ, Inst Psychol, Hlth Med & Neuropsychol Unit, Leiden, Netherlands.
   [Weijs, Peter J. M.] Vrije Univ, Amsterdam UMC, Dept Nutr & Dietet, Amsterdam, Netherlands.
   [Walrabenstein, Wendy; Wagenaar, Carlijn A.; van de Put, Marieke; van der Leeden, Marike; Gerritsen, Martijn; Twisk, Jos W. R.; van der Esch, Martin; van Middendorp, Henriet; Weijs, Peter J. M.; Roorda, Leo D.; van Schaardenburg, Dirkjan] Amsterdam Rehabil Res Ctr Reade, Amsterdam, Netherlands.
   [Walrabenstein, Wendy] Reade Ctr Rheumatol & Rehabil, Dr Jan Breemenstr 2, NL-1056 AB Amsterdam, Netherlands.
C3 University of Amsterdam; Vrije Universiteit Amsterdam; University of
   Amsterdam; Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam;
   University of Amsterdam; Leiden University; Leiden University - Excl
   LUMC; Vrije Universiteit Amsterdam; University of Amsterdam
RP Walrabenstein, W (corresponding author), Reade Ctr Rheumatol & Rehabil, Dr Jan Breemenstr 2, NL-1056 AB Amsterdam, Netherlands.
EM w.walrabenstein@reade.nl
RI van Middendorp, Henriet/B-8300-2013
OI van Middendorp, Henriet/0000-0003-4575-0895; Walrabenstein,
   Wendy/0000-0002-2428-2845; Wagenaar, Carlijn/0000-0002-0937-4450
FU Reade (Amsterdam, the Netherlands); Reade Foundation (Amsterdam, the
   Netherlands); Stichting Vermeer 14 (private foundation, Amsterdam, the
   Netherlands); W.M. de Hoop Stichting (private foundation, Bussum, the
   Netherlands); Netherlands Organisation for Health Research and
   Development (ZonMw) [555003210]
FX The RCT is funded by Reade (Amsterdam, the Netherlands) , Reade
   Foundation (Amsterdam, the Netherlands) , Stichting Vermeer 14 (private
   foundation, Amsterdam, the Netherlands) , and W.M. de Hoop Stichting
   (private foundation, Bussum, the Netherlands) . The position of Carlijn
   Wagenaar is funded by The Netherlands Organisation for Health Research
   and Development (ZonMw) no. 555003210.
CR ALTMAN R, 1991, ARTHRITIS RHEUM, V34, P505, DOI 10.1002/art.1780340502
   ALTMAN R, 1986, ARTHRITIS RHEUM-US, V29, P1039, DOI 10.1002/art.1780290816
   Alwarith J, 2019, FRONT NUTR, V6, DOI 10.3389/fnut.2019.00141
   Barnard ND, 2009, J AM DIET ASSOC, V109, P263, DOI 10.1016/j.jada.2008.10.049
   Barnard ND, 2009, AM J CLIN NUTR, V89, pS1588, DOI 10.3945/ajcn.2009.26736H
   Bennell KL, 2022, ANN INTERN MED, V175, P198, DOI 10.7326/M21-2388
   Buckland-Wright C, 2006, BEST PRACT RES CL RH, V20, P39, DOI 10.1016/j.berh.2005.08.002
   Burrows TL, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00850
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Clinton C, 2015, ARTHRITIS, DOI 10.1155/2015/708152
   Courties A, 2017, CURR OPIN RHEUMATOL, V29, P214, DOI 10.1097/BOR.0000000000000373
   de Brouwer SJM, 2013, ARTHRITIS RES THER, V15, DOI 10.1186/ar4390
   Eyles JP, 2019, OSTEOARTHR CARTILAGE, V27, P1270, DOI 10.1016/j.joca.2019.05.015
   Fernandes L, 2013, ANN RHEUM DIS, V72, P1125, DOI 10.1136/annrheumdis-2012-202745
   Fffff K.F., 2010, FFFBMC MED, V8, DOI [10.1186/1741-7015-8-18ffff, DOI 10.1186/1741-7015-8-18FFFF]
   Frampton J, 2021, J CACHEXIA SARCOPENI, V12, P2134, DOI 10.1002/jcsm.12820
   Furman D, 2019, NAT MED, V25, P1822, DOI 10.1038/s41591-019-0675-0
   Genel F, 2020, J NUTR SCI, V9, DOI 10.1017/jns.2020.31
   Geyer M, 2018, CURR RHEUMATOL REV, V14, P98, DOI 10.2174/1573397113666170807122312
   Global Burden of Disease Collaborative Network, Global Burden of Disease Study 2021 (GBD 2021) Socio-Demographic Index (SDI) 1950-2021
   Grundy SM, 2004, CIRCULATION, V109, P551, DOI 10.1161/01.CIR.0000112379.88385.67
   Hall KD, 2021, NAT MED, V27, P344, DOI 10.1038/s41591-020-01209-1
   Hayek MN, 2021, NAT SUSTAIN, V4, P21, DOI 10.1038/s41893-020-00603-4
   healthdata, Global Burden of Disease Study 2019 (GBD 2019) Disability Weights
   Hunter DJ, 2019, LANCET, V393, P1745, DOI 10.1016/S0140-6736(19)30417-9
   Kahleova H, 2017, NUTRIENTS, V9, DOI 10.3390/nu9080848
   KELLGREN JH, 1957, ANN RHEUM DIS, V16, P494, DOI 10.1136/ard.16.4.494
   Kromhout D, 2016, EUR J CLIN NUTR, V70, P869, DOI 10.1038/ejcn.2016.52
   Lee AC, 2017, ARCH PHYS MED REHAB, V98, P2265, DOI 10.1016/j.apmr.2017.04.014
   Melina V, 2016, J ACAD NUTR DIET, V116, P1970, DOI 10.1016/j.jand.2016.09.025
   Menzel J, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-78426-8
   Messier SP, 2004, ARTHRITIS RHEUM-US, V50, P1501, DOI 10.1002/art.20256
   Messier SP, 2013, JAMA-J AM MED ASSOC, V310, P1263, DOI 10.1001/jama.2013.277669
   Miller GD, 2006, OBESITY, V14, P1219, DOI 10.1038/oby.2006.139
   Mobasheri A, 2017, NAT REV RHEUMATOL, V13, P302, DOI 10.1038/nrrheum.2017.50
   Ocké M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13041135
   Ornish D, 1998, JAMA-J AM MED ASSOC, V280, P2001, DOI 10.1001/jama.280.23.2001
   Ornish D, 2013, LANCET ONCOL, V14, P1112, DOI 10.1016/S1470-2045(13)70366-8
   Puenpatom RA, 2009, POSTGRAD MED, V121, P9, DOI 10.3810/pgm.2009.11.2073
   Reyes C, 2016, ARTHRITIS RHEUMATOL, V68, P1869, DOI 10.1002/art.39707
   richtlijnendatabase nl, Conservatieve behandeling van artrose in heup of knie
   Rizzo NS, 2011, DIABETES CARE, V34, P1225, DOI 10.2337/dc10-1221
   Roorda LD, 2004, ANN RHEUM DIS, V63, P36, DOI 10.1136/ard.2002.001784
   Salis Z, 2023, ARTHRITIS RHEUMATOL, V75, P533, DOI 10.1002/art.42307
   Sarin HV, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-40107-6
   Terwee CB, 2014, QUAL LIFE RES, V23, P1733, DOI 10.1007/s11136-013-0611-6
   Terwee CB, 2021, QUAL LIFE RES, V30, P2729, DOI 10.1007/s11136-021-02925-y
   Tubach F, 2005, ANN RHEUM DIS, V64, P29, DOI 10.1136/ard.2004.022905
   Turkiewicz A, 2014, OSTEOARTHR CARTILAGE, V22, P1826, DOI 10.1016/j.joca.2014.07.015
   vtv2018 nl, Public Health Foresight Study 2018. (VTV-2018): Diseases
   Walrabenstein W, 2021, TRIALS, V22, DOI 10.1186/s13063-021-05682-y
   Wang HR, 2016, SCI REP-UK, V6, DOI 10.1038/srep39672
   Weggemans RM, 2018, INT J BEHAV NUTR PHY, V15, DOI 10.1186/s12966-018-0661-9
   Willett W, 2019, LANCET, V393, P447, DOI 10.1016/S0140-6736(18)31788-4
NR 54
TC 18
Z9 18
U1 1
U2 6
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1063-4584
EI 1522-9653
J9 OSTEOARTHR CARTILAGE
JI Osteoarthritis Cartilage
PD NOV
PY 2023
VL 31
IS 11
BP 1491
EP 1500
DI 10.1016/j.joca.2023.05.014
EA OCT 2023
PG 10
WC Orthopedics; Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rheumatology
GA Y6LL0
UT WOS:001106353200001
PM 37328047
OA hybrid
DA 2025-06-11
ER

PT J
AU Patel, SA
   Dhillon, PK
   Kondal, D
   Jeemon, P
   Kahol, K
   Manimunda, SP
   Purty, AJ
   Deshpande, A
   Negi, PC
   Ladhani, S
   Toteja, GS
   Patel, V
   Prabhakaran, D
AF Patel, Shivani A.
   Dhillon, Preet K.
   Kondal, Dimple
   Jeemon, Panniyammakal
   Kahol, Kashvi
   Manimunda, Sathya Prakash
   Purty, Anil J.
   Deshpande, Ajit
   Negi, P. C.
   Ladhani, Sulaiman
   Toteja, Gurudayal Singh
   Patel, Vikram
   Prabhakaran, Dorairaj
TI Chronic disease concordance within Indian households: A cross-sectional
   study
SO PLOS MEDICINE
LA English
DT Article
ID METABOLIC SYNDROME; FAMILIAL AGGREGATION; SPOUSAL CONCORDANCE;
   MARRIED-COUPLES; CORONARY RISK; HEALTH; HEART; COMPONENTS; ADULTS
AB Background
   The household is a potentially important but understudied unit of analysis and intervention in chronic disease research. We sought to estimate the association between living with someone with a chronic condition and one's own chronic condition status.
   Methods and findings
   We conducted a cross-sectional analysis of population-based household-and individual-level data collected in 4 socioculturally and geographically diverse settings across rural and urban India in 2013 and 2014. Of 10,703 adults ages 18 years and older with coresiding household members surveyed, data from 7,522 adults (mean age 39 years) in 2,574 households with complete covariate information were analyzed. The main outcome measures were diabetes (fasting plasma glucose >= 126 mg/dL or taking medication), common mental disorder (General Health Questionnaire score >= 12), hypertension (blood pressure >= 140/90 mmHg or taking medication), obesity (body mass index >= 30 kg/m(2)), and high cholesterol (total blood cholesterol >= 240 mg/dL or taking medication). Logistic regression with generalized estimating equations was used to model associations with adjustment for a participant's age, sex, education, marital status, religion, and study site. Inverse probability weighting was applied to account for missing data. We found that 44% of adults had 1 or more of the chronic conditions examined. Irrespective of familial relationship, adults who resided with another adult with any chronic condition had 29% higher adjusted relative odds of having 1 or more chronic conditions themselves (adjusted odds ratio [aOR] = 1.29; 95% confidence interval [95% CI] 1.10-1.50). We also observed positive statistically significant associations of diabetes, common mental disorder, and hypertension with any chronic condition (aORs ranging from 1.19 to 1.61) in the analysis of all coresiding household members. Associations, however, were stronger for concordance of certain chronic conditions among coresiding household members. Specifically, we observed positive statistically significant associations between living with another adult with diabetes (aOR = 1.60; 95% CI 1.23-2.07), common mental disorder (aOR = 2.69; 95% CI 2.12-3.42), or obesity (aOR = 1.82; 95% CI 1.33-2.50) and having the same condition. Among separate analyses of dyads of parents and their adult children and dyads of spouses, the concordance between the chronic disease status was striking. The associations between common mental disorder, hypertension, obesity, and high cholesterol in parents and those same conditions in their adult children were aOR = 2.20 (95% CI 1.28-3.77), 1.58 (95% CI 1.15-2.16), 4.99 (95% CI 2.71-9.20), and 2.57 (95% CI 1.15-5.73), respectively. The associations between diabetes and common mental disorder in husbands and those same conditions in their wives were aORs = 2.28 (95% CI 1.52-3.42) and 3.01 (95% CI 2.01-4.52), respectively. Relative odds were raised even across different chronic condition phenotypes; specifically, we observed positive statistically significant associations between hypertension and obesity in the total sample of all coresiding adults (aOR = 1.24; 95% CI 1.02-1.52), high cholesterol and diabetes in the adult-parent sample (aOR = 2.02; 95% CI 1.08-3.78), and hypertension and diabetes in the spousal sample (aOR = 1.51; 95% CI 1.05-2.17). Of all associations examined, only the relationship between hypertension and diabetes in the adult-parent dyads was statistically significantly negative (aOR = 0.62; 95% CI 0.40-0.94). Relatively small samples in the dyadic analysis and site-specific analysis call for caution in interpreting qualitative differences between associations among different dyad types and geographical locations.
   Because of the cross-sectional nature of the analysis, the findings do not provide information on the etiology of incident chronic conditions among household members.
   Conclusions
   We observed strong concordance of chronic conditions within coresiding adults across diverse settings in India. These data provide early evidence that a household-based approach to chronic disease research may advance public health strategies to prevent and control chronic conditions.
C1 [Patel, Shivani A.; Kondal, Dimple; Prabhakaran, Dorairaj] Ctr Chron Dis Control, Gurugram, Haryana, India.
   [Patel, Shivani A.] Emory Univ, Hubert Dept Global Hlth, Atlanta, GA 30322 USA.
   [Dhillon, Preet K.; Kondal, Dimple; Jeemon, Panniyammakal; Kahol, Kashvi; Patel, Vikram; Prabhakaran, Dorairaj] Publ Hlth Fdn India, Gurugram, Haryana, India.
   [Manimunda, Sathya Prakash] Indian Council Med Res, Natl Ctr Dis Informat & Res, Bengaluru, India.
   [Purty, Anil J.] Pondicherry Inst Med Sci, Kalapet, Puducherry, India.
   [Deshpande, Ajit] Sri Aurobindo Inst Med Sci, Indore, Madhya Pradesh, India.
   [Negi, P. C.] Indira Gandhi Med Coll, Shimla, Himachal Prades, India.
   [Ladhani, Sulaiman] Aga Khan Hlth Serv, Bombay, Maharashtra, India.
   [Toteja, Gurudayal Singh] Indian Council Med Res, New Delhi, India.
   [Patel, Vikram] Harvard Med Sch, Dept Global Hlth & Social Med, Boston, MA USA.
   [Jeemon, Panniyammakal] Sree Chitra Tirunal Inst Med Sci & Technol, Trivandrum, Kerala, India.
C3 Emory University; Public Health Foundation of India; Indian Council of
   Medical Research (ICMR); ICMR - National Centre for Disease Informatics
   & Research (NCDIR); Pondicherry Institute of Medical Sciences; Indira
   Gandhi Medical College & Hospital Shimla; Indian Council of Medical
   Research (ICMR); Harvard University; Harvard Medical School; Department
   of Science & Technology (India); Sree Chitra Tirunal Institute for
   Medical Sciences Technology (SCTIMST)
RP Patel, SA (corresponding author), Ctr Chron Dis Control, Gurugram, Haryana, India.; Patel, SA (corresponding author), Emory Univ, Hubert Dept Global Hlth, Atlanta, GA 30322 USA.
EM s.a.patel@emory.edu
RI Patel, Vikram/ADE-3787-2022; Prabhakaran, Dorairaj/B-4147-2011
OI Patel, Shivani/0000-0003-0082-5857; Jeemon,
   Panniyammakal/0000-0003-4172-4307; Prabhakaran,
   Dorairaj/0000-0002-3172-834X
FU Division of Reproductive Health and Nutrition of Indian Council of
   Medical Research [RHN/NTF/4/2011-2012]; Division of Reproductive Health
   and Nutrition of Indian Council of Medical Research
   [RHN/NTF/4/2011-2012]
FX The data collection was funded by the Division of Reproductive Health
   and Nutrition of Indian Council of Medical Research
   (http://icmr.nic.in/) vide grant RFC NO: RHN/NTF/4/2011-2012 dated
   28.03.2012. The authors received no specific funding for this
   manuscript.
CR Amer Diabet Assoc, 2014, DIABETES CARE, V37, pS14, DOI 10.2337/dc14-S014
   [Anonymous], WORLD FAM MAP 2014 M
   [Anonymous], 2012, INDIAS GROWTH SPILLO
   Chatterji S, 2008, HEALTH AFFAIR, V27, P1052, DOI 10.1377/hlthaff.27.4.1052
   Chen W, 2001, ANN EPIDEMIOL, V11, P522, DOI 10.1016/S1047-2797(01)00228-9
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cobb LK, 2016, AM J EPIDEMIOL, V183, P435, DOI 10.1093/aje/kwv112
   Desai S. B., 2010, Human Development in India: Challenges for a Society in Transition
   Di Castelnuovo A, 2009, AM J EPIDEMIOL, V169, P1, DOI 10.1093/aje/kwn234
   Falba TA, 2008, HEALTH SERV RES, V43, P96, DOI 10.1111/j.1475-6773.2007.00754.x
   Gupta S, 2013, J BIOSOC SCI, V45, P1, DOI 10.1017/S0021932012000478
   Hippisley-Cox J, 2002, BMJ-BRIT MED J, V325, P636, DOI 10.1136/bmj.325.7365.636
   Hirst M, 2005, SOC SCI MED, V61, P697, DOI 10.1016/j.socscimed.2005.01.001
   Hu Y, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-686
   James PA, 2014, JAMA-J AM MED ASSOC, V311, P1809, DOI [10.1001/jama.2013.284427, 10.1001/jama.2014.4346]
   Jeemon P, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-2891-6
   Jurj AL, 2006, ANN EPIDEMIOL, V16, P285, DOI 10.1016/j.annepidem.2005.07.060
   Kassebaum NJ, 2016, LANCET, V388, P1603, DOI 10.1016/S0140-6736(16)31460-X
   Kim HC, 2006, ANN EPIDEMIOL, V16, P292, DOI 10.1016/j.annepidem.2005.07.052
   Kuruvilla A, 1999, Indian J Psychiatry, V41, P217
   Lee C, 2014, J AGING HEALTH, V26, P952, DOI 10.1177/0898264314534894
   Lee KE, 2003, BMC GENET, V4, DOI 10.1186/1471-2156-4-S1-S94
   Lee MH, 2011, DIABETES RES CLIN PR, V93, P430, DOI 10.1016/j.diabres.2011.06.002
   LIANG KY, 1986, BIOMETRIKA, V73, P13, DOI 10.1093/biomet/73.1.13
   Lichtenstein AH, 2006, ARTERIOSCL THROM VAS, V26, P2186, DOI 10.1161/01.ATV.0000238352.25222.5e
   Meyler D, 2007, SOC SCI MED, V64, P2297, DOI 10.1016/j.socscimed.2007.02.007
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Murray CJL, 2015, LANCET, V386, P2145, DOI 10.1016/S0140-6736(15)61340-X
   Park HS, 2006, ATHEROSCLEROSIS, V186, P215, DOI 10.1016/j.atherosclerosis.2005.07.019
   Patel V, 2008, PSYCHOL MED, V38, P221, DOI 10.1017/S0033291707002334
   Patel V, 2011, LANCET, V377, P413, DOI 10.1016/S0140-6736(10)61188-9
   Pearlin LI, 1997, J HEALTH SOC BEHAV, V38, P223, DOI 10.2307/2955368
   Pi-Sunyer FX, 1998, OBES RES, V6, p51S
   Pyke SDM, 1997, ARCH FAM MED, V6, P354, DOI 10.1001/archfami.6.4.354
   Rothman K J, 1990, Epidemiology, V1, P43, DOI 10.1097/00001648-199001000-00010
   Ruggles S, 2008, POPUL DEV REV, V34, P253, DOI 10.1111/j.1728-4457.2008.00219.x
   SCHULZ R, 1995, GERONTOLOGIST, V35, P771, DOI 10.1093/geront/35.6.771
   Seaman SR, 2013, STAT METHODS MED RES, V22, P278, DOI 10.1177/0962280210395740
   Siegel KR, 2014, BRIT MED BULL, V111, P31, DOI 10.1093/bmb/ldu018
   SMITH KR, 1994, DEMOGRAPHY, V31, P81, DOI 10.2307/2061909
   UMBERSON D, 1987, J HEALTH SOC BEHAV, V28, P306, DOI 10.2307/2136848
   Vaezghasemi M, 2016, INT J EQUITY HEALTH, V15, DOI 10.1186/s12939-016-0388-7
   Wilson SE, 2002, SOC SCI MED, V55, P1157, DOI 10.1016/S0277-9536(01)00253-2
   Feng Y, 2008, OBESITY, V16, P125, DOI 10.1038/oby.2007.22
   Yoon PW, 2002, GENET MED, V4, P304, DOI 10.1097/00125817-200207000-00009
NR 45
TC 40
Z9 44
U1 0
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1549-1277
EI 1549-1676
J9 PLOS MED
JI PLos Med.
PD SEP
PY 2017
VL 14
IS 9
AR e1002395
DI 10.1371/journal.pmed.1002395
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA FI4TS
UT WOS:000411970300015
PM 28961237
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Fazelian, S
   Paknahad, Z
   Khajehali, L
   Kheiri, S
   Amani, R
AF Fazelian, Siavash
   Paknahad, Zamzam
   Khajehali, Leila
   Kheiri, Soleiman
   Amani, Reza
TI The effects of supplementation with vitamin D on inflammatory
   biomarkers, omentin, and vaspin in women with type 2 diabetes: A
   randomized double-blind placebo-controlled clinical trial
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE diabetes; hs-CRP; Omentin; vaspin; vitamin D; women
ID ADIPOSE-TISSUE; INSULIN-RESISTANCE; METABOLIC SYNDROME; GLYCEMIC
   CONTROL; ANXIETY; ADIPOCYTOKINE; ASSOCIATION; POPULATION; PREVALENCE;
   CALCIUM
AB Type 2 diabetes (T2DM) is a global problem that increases the risk of inflammation and hormonal dysfunction. The purpose of this study was to determine the effect of vitamin D on inflammatory biomarkers, omentin, and vaspin in diabetic women with anxiety. In this study, 51 women with T2DM were allocated to receive one oral pearl of 50,000 IU vitamin D-3(26) or a placebo (25) fortnightly for 16 weeks. Anthropometric indices, dietary intake, high sensitivity C-reactive protein (hs-CRP), Interleukin 10 (IL-10), vaspin, and omentin were measured at the baseline and after 16-weeks supplementation. Serum hs-CRP was reduced (p = 0.01) and IL-10 concentrations was increased (p = 0.04) in intervention group. Vitamin D marginally increased serum levels of omentin (p = 0.06), however, vaspin did not change post-intervention. According to subgroup analysis, omentin levels increased significantly in participants with lower baseline serum vitamin D (p = 0.008). Vitamin D can improve anti-inflammatory biomarkers in diabetic patients.
C1 [Fazelian, Siavash; Paknahad, Zamzam; Amani, Reza] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Food Secur Res Ctr, Dept Clin Nutr, Esfahan, Iran.
   [Khajehali, Leila] Imam Ali Hosp Farokhshahr, Social Secur Org, Shahrekord, Iran.
   [Kheiri, Soleiman] Shahrekord Univ Med Sci, Sch Hlth, Dept Epidemiol, Shahrekord, Iran.
   [Kheiri, Soleiman] Shahrekord Univ Med Sci, Sch Hlth, Dept Biostat, Shahrekord, Iran.
C3 Isfahan University of Medical Sciences; Shahrekord University Medical
   Sciences; Shahrekord University Medical Sciences
RP Amani, R (corresponding author), Isfahan Univ Med Sci, Sch Nutr & Food Sci, Food Secur Res Ctr, Dept Clin Nutr, Esfahan, Iran.
EM r_amani@nutr.mui.ac.ir
RI paknahad, zamzam/E-6191-2012; Kheiri, Soleiman/K-2401-2017; Amani,
   Reza/U-7483-2017
OI Amani, Reza/0000-0002-0074-4080; paknahad, zamzam/0000-0002-1864-2576
FU Isfahan University of Medical Sciences
FX This paper was a part of Siavash Fazelain's Ph.D dissertation. The costs
   of laboratory tests were covered by a grant provided by Vice-Chancellor
   for Research, Isfahan University of Medical Sciences. Hereby, the
   authors wish to acknowledge all participants for their kind cooperation.
CR Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
   Asemi Z, 2014, DIABETOLOGIA, V57, P1798, DOI 10.1007/s00125-014-3293-x
   Asghari A., 2008, Int J Psychol, V2, P82
   Ashtari F, 2015, NEUROIMMUNOMODULAT, V22, P400, DOI 10.1159/000439278
   Assadi M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024240
   Barker T, 2015, CYTOKINE, V71, P132, DOI 10.1016/j.cyto.2014.09.012
   Batista CMDS, 2007, DIABETES, V56, P1655, DOI 10.2337/db06-1506
   Bellia A, 2013, INTERN EMERG MED, V8, P33, DOI 10.1007/s11739-011-0559-x
   Bertoni AG, 2010, DIABETES CARE, V33, P804, DOI 10.2337/dc09-1679
   Brito V, 2015, ARCH CARDIOL MEX, V85, P124, DOI 10.1016/j.acmx.2014.11.005
   Chen YZ, 2011, ARCH BIOCHEM BIOPHYS, V507, P241, DOI 10.1016/j.abb.2010.12.020
   Dikker O, 2018, EXP CLIN ENDOCR DIAB, V126, P316, DOI 10.1055/s-0043-120110
   Ding C, 2012, BRIT J NUTR, V108, P1915, DOI 10.1017/S0007114512003285
   Fogelholm M, 2006, MED SCI SPORT EXER, V38, P753, DOI 10.1249/01.mss.0000194075.16960.20
   Gao D, 2011, J CELL PHYSIOL, V226, P2869, DOI 10.1002/jcp.22630
   Garcia C, 2010, DIABETES METAB, V36, P327, DOI 10.1016/j.diabet.2010.07.001
   George PS, 2012, DIABETIC MED, V29, pE142, DOI 10.1111/j.1464-5491.2012.03672.x
   Grigsby AB, 2002, J PSYCHOSOM RES, V53, P1053, DOI 10.1016/S0022-3999(02)00417-8
   Hejazi E., 2014, MULT SCLER INT, V2014, P1
   Hida K, 2005, P NATL ACAD SCI USA, V102, P10610, DOI 10.1073/pnas.0504703102
   Holick Michael F, 2011, J Clin Endocrinol Metab, V96, P1911, DOI 10.1210/jc.2011-0385
   Husemoen LLN, 2012, DIABETES CARE, V35, P1695, DOI 10.2337/dc11-1309
   Jafari T, 2016, CLIN NUTR, V35, P67, DOI 10.1016/j.clnu.2015.02.014
   Jaganathan R, 2018, CAN J DIABETES, V42, P446, DOI 10.1016/j.jcjd.2017.10.040
   Jamilian M, 2017, NUTRIENTS, V9, DOI 10.3390/nu9121280
   Kovacs P., 2016, UDIPOKINES, V135
   Li GW, 2014, J CLIN ENDOCR METAB, V99, P757, DOI 10.1210/jc.2013-3450
   McGill A, 2009, OBESITY METABOLISM, V6, P52, DOI DOI 10.14341/2071-8713-4887
   Moradi S, 2016, EUR J NUTR, V55, P1297, DOI 10.1007/s00394-015-0948-4
   Mousa A, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201700488
   Newby PK, 2004, AM J CLIN NUTR, V80, P504, DOI 10.1093/ajcn/80.2.504
   Pan HY, 2010, DIABETES RES CLIN PR, V88, P29, DOI 10.1016/j.diabres.2010.01.013
   Pinelli NR, 2010, DIABETES CARE, V33, P1373, DOI 10.2337/dc09-2199
   Prietl B, 2013, NUTRIENTS, V5, P2502, DOI 10.3390/nu5072502
   Rahimlou M, 2016, DIABETES METAB SYND, V10, pS60, DOI 10.1016/j.dsx.2015.09.015
   Salekzamani S, 2016, J ENDOCRINOL INVEST, V39, P1303, DOI 10.1007/s40618-016-0507-8
   Samani S., 2007, Journal of Social Sciences and Humanities, V26, P65
   Sharifi N, 2016, EXP BIOL MED, V241, P830, DOI 10.1177/1535370216629009
   Song YQ, 2013, DIABETES CARE, V36, P1422, DOI 10.2337/dc12-0962
   Suda T, 2003, J CELL BIOCHEM, V88, P259, DOI 10.1002/jcb.10331
   Tan BK, 2010, TRENDS CARDIOVAS MED, V20, P143, DOI 10.1016/j.tcm.2010.12.002
   Tayefi M, 2017, PSYCHONEUROENDOCRINO, V81, P63, DOI 10.1016/j.psyneuen.2017.02.035
   Thomas J, 2003, DIABETES CARE, V26, P2311, DOI 10.2337/diacare.26.8.2311
   Weaver CM, 2016, OSTEOPOROSIS INT, V27, P2641, DOI 10.1007/s00198-016-3525-7
   Webb AR, 2006, PROG BIOPHYS MOL BIO, V92, P17, DOI 10.1016/j.pbiomolbio.2006.02.004
   World Medical Association General Assembly, 2004, J Int Bioethique, V15, P124
   Yang RZ, 2006, AM J PHYSIOL-ENDOC M, V290, pE1253, DOI 10.1152/ajpendo.00572.2004
   Yang RZ, 2003, DIABETES, V52, pA1
   Zabetian-Targhi F, 2016, J AM COLL NUTR, V35, P670, DOI 10.1080/07315724.2015.1126207
   Zhang JY, 2017, STEM CELLS DEV, V26, P1749, DOI 10.1089/scd.2017.0119
   Zittermann A, 2009, AM J CLIN NUTR, V89, P1321, DOI 10.3945/ajcn.2008.27004
   Zorlu M, 2016, EXP CLIN ENDOCR DIAB, V124, P440, DOI 10.1055/s-0042-108853
NR 52
TC 8
Z9 8
U1 0
U2 8
PU WILEY-HINDAWI
PI LONDON
PA ADAM HOUSE, 3RD FL, 1 FITZROY SQ, LONDON, WIT 5HE, ENGLAND
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD DEC
PY 2018
VL 42
IS 6
AR e12631
DI 10.1111/jfbc.12631
PG 9
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA HJ1RP
UT WOS:000456942100006
OA gold
DA 2025-06-11
ER

PT J
AU Agusti, A
   Moya-Pérez, A
   Campillo, I
   Montserrat-de la Paz, S
   Cerrudo, V
   Perez-Villalba, A
   Sanz, Y
AF Agusti, Ana
   Moya-Perez, A.
   Campillo, I.
   Montserrat-de la Paz, S.
   Cerrudo, V.
   Perez-Villalba, A.
   Sanz, Yolanda
TI Bifidobacterium pseudocatenulatum CECT 7765 Ameliorates
   Neuroendocrine Alterations Associated with an Exaggerated Stress
   Response and Anhedonia in Obese Mice
SO MOLECULAR NEUROBIOLOGY
LA English
DT Article
DE Obesity; Bifidobacterium; Microbiota; Depression; Stress; Serotonin;
   TLR2
ID MAJOR DEPRESSIVE DISORDER; UNPREDICTABLE MILD STRESS;
   IRRITABLE-BOWEL-SYNDROME; HIGH-FAT-DIET; BEHAVIORAL ALTERATIONS;
   INTESTINAL MICROBIOTA; METABOLIC SYNDROME; GENE-EXPRESSION; GUT
   MICROBIOTA; SOCIAL STRESS
AB Obesity, besides being a problem of metabolic dysfunction, constitutes a risk factor for psychological disorders. Experimental models of diet-induced obesity have revealed that obese animals are prone to anxious and depressive-like behaviors. The present study aimed to evaluate whether Bifidobacterium pseudocatenulatum CECT 7765 could reverse the neurobehavioral consequences of obesity in a high-fat diet (HFD) fed mouse model via regulation of the gut-brain axis. Adult male wild-type C57BL-6 mice were fed a standard diet or HFD, supplemented with either placebo or the bifidobacterial strain for 13 weeks. Behavioral tests were performed, and immune and neuroendocrine parameters were analyzed including leptin and corticosterone and their receptors, Toll-like receptor 2 (TLR2) and neurotransmitters. We found that obese mice showed anhedonia (p < 0.050) indicative of a depressive-like behavior and an exaggerated hypothalamic-pituitary axis (HPA)-mediated stress response to acute physical (p < 0.001) and social stress (p < 0.050), but these alterations were ameliorated by B. pseudocatenulatum CECT 7765 (p < 0.050). These behavioral effects were parallel to reductions of the obesity-associated hyperleptinemia (p < 0.001) and restoration of leptin signaling (p < 0.050), along with fat mass loss (p < 0.010). B. pseudocatenulatum CECT 7765 administration also led to restoration of the obesity-induced reductions in adrenaline in the hypothalamus (p < 0.010), involved in the hypothalamic control of energy balance. Furthermore, the bifidobacterial strain reduced the obesity-induced upregulation of TLR2 protein or gene expression in the intestine (p < 0.010) and the hippocampus (p < 0.050) and restored the alterations of 5-HT levels in the hippocampus (p < 0.050), which could contribute to attenuating the obesity-associated depressive-like behavior (p < 0.050). In summary, the results indicate that B. pseudocatenulatum CECT 7765 could play a role in depressive behavior comorbid with obesity via regulation of endocrine and immune mediators of the gut-brain axis.
C1 [Agusti, Ana; Moya-Perez, A.; Campillo, I.; Montserrat-de la Paz, S.; Cerrudo, V.; Perez-Villalba, A.; Sanz, Yolanda] CNR, Inst Agrochem & Food Technol, Nutr & Hlth Res Unit, Microbial Ecol,IATA CSIC, C Catedrat Agustin Escardino 7, Paterna Valencia 46980, Spain.
   [Agusti, Ana; Moya-Perez, A.; Campillo, I.; Montserrat-de la Paz, S.; Cerrudo, V.; Perez-Villalba, A.; Sanz, Yolanda] Univ Valencia, Cell Biol Dept, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Valencia, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); Instituto de
   Agroquimica y Tecnologia de los Alimentos (IATA); University of
   Valencia; CIBERNED
RP Agusti, A; Sanz, Y (corresponding author), CNR, Inst Agrochem & Food Technol, Nutr & Hlth Res Unit, Microbial Ecol,IATA CSIC, C Catedrat Agustin Escardino 7, Paterna Valencia 46980, Spain.; Agusti, A; Sanz, Y (corresponding author), Univ Valencia, Cell Biol Dept, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Valencia, Spain.
EM aagusti@iata.csic.es; yolsanz@iata.csic.es
RI Feliu, Ana/AAB-1445-2020; Perez-Villalba, Ana/HTT-4372-2023; la Paz,
   Sergio/Z-3447-2019; Perez, Ana/L-9214-2014; Sanz, Yolanda/H-5498-2012
OI Montserrat-de la Paz, Sergio/0000-0001-5400-3192; Perez,
   Ana/0000-0002-5330-2374; Agusti, Ana/0000-0001-9005-574X; Sanz,
   Yolanda/0000-0002-1615-1976; Cerrudo, Victor/0000-0003-1678-990X
FU Spanish Ministry of Economy and Competitiveness (MINECO)
   [AGL2014-52101-P]; MECD; MINECO; CIBERNED
FX This work and the contract of AA were supported by grant AGL2014-52101-P
   from the Spanish Ministry of Economy and Competitiveness (MINECO). The
   scholarship of AM from MECD and the PTA contract of IC from MINECO are
   also fully acknowledged. CIBERNED funding AP is also acknowledged.
CR Barouei J, 2015, BENEF MICROBES, V6, P83, DOI 10.3920/BM2013.0011
   Boukouvalas G, 2010, CELL MOL NEUROBIOL, V30, P521, DOI 10.1007/s10571-009-9476-1
   Buyse M, 2001, EUR J NEUROSCI, V14, P64, DOI 10.1046/j.0953-816x.2001.01628.x
   Carvalho AF, 2014, J PSYCHIATR RES, V59, P28, DOI 10.1016/j.jpsychires.2014.08.002
   Castagné V, 2009, FRONT NEUROSCI, P103
   Colelli V, 2014, NEUROBIOL LEARN MEM, V111, P49, DOI 10.1016/j.nlm.2014.03.004
   Collins SM, 2012, NAT REV MICROBIOL, V10, P735, DOI 10.1038/nrmicro2876
   Cooke AA, 2016, EUR J PHARMACOL, V785, P207, DOI 10.1016/j.ejphar.2016.04.021
   CRAWLEY J, 1980, PHARMACOL BIOCHEM BE, V13, P167, DOI 10.1016/0091-3057(80)90067-2
   Dale E, 2016, CNS SPECTRUMS, V21, P143, DOI 10.1017/S1092852915000425
   de Kloet ER, 2005, NAT REV NEUROSCI, V6, P463, DOI 10.1038/nrn1683
   De Miguel Z, 2011, BEHAV BRAIN RES, V225, P554, DOI 10.1016/j.bbr.2011.08.011
   De Palma G, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8735
   De Souza CT, 2005, ENDOCRINOLOGY, V146, P4192, DOI 10.1210/en.2004-1520
   DENENBERG VH, 1969, ANN NY ACAD SCI, V159, P852, DOI 10.1111/j.1749-6632.1969.tb12983.x
   Duncko R, 2001, CELL MOL NEUROBIOL, V21, P403, DOI 10.1023/A:1012658222954
   Farshim P, 2016, SCI REP-UK, V6, DOI 10.1038/srep21958
   Cano PG, 2013, OBESITY, V21, P2310, DOI 10.1002/oby.20330
   Gotthardt JD, 2016, ENDOCRINOLOGY, V157, P679, DOI 10.1210/en.2015-1622
   Hageman I, 2009, BEHAV BRAIN RES, V196, P71, DOI 10.1016/j.bbr.2008.07.037
   Hamer M, 2012, MOL PSYCHIATR, V17, P940, DOI 10.1038/mp.2012.30
   Hanstock TL, 2010, PHYSIOL BEHAV, V101, P653, DOI 10.1016/j.physbeh.2010.09.018
   Hayward Jin Hee, 2014, Exp Neurobiol, V23, P138, DOI 10.5607/en.2014.23.2.138
   Himes RW, 2010, FASEB J, V24, P731, DOI 10.1096/fj.09-141929
   Hwang DH, 2016, EUR J PHARMACOL, V785, P24, DOI 10.1016/j.ejphar.2016.04.024
   Jeon BT, 2012, DIABETES, V61, P1444, DOI 10.2337/db11-1498
   Kempuraj D, 2016, J Neurol Neurosurg Spine, V1
   Kesby JP, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0140034
   Kim C, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms2534
   Latorre E, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0169303
   Liu CS, 2014, CNS NEUROL DISORD-DR, V13, P1693
   Liu J, 2016, INT J NEUROPSYCHOPH, V19, DOI 10.1093/ijnp/pyv115
   Logan AC, 2005, MED HYPOTHESES, V64, P533, DOI 10.1016/j.mehy.2004.08.019
   Lopresti AL, 2014, PROG NEURO-PSYCHOPH, V48, P102, DOI 10.1016/j.pnpbp.2013.09.017
   Lu XY, 2006, P NATL ACAD SCI USA, V103, P1593, DOI 10.1073/pnas.0508901103
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Ma J, 2010, OBESITY, V18, P347, DOI 10.1038/oby.2009.213
   MAFFEI M, 1995, NAT MED, V1, P1155, DOI 10.1038/nm1195-1155
   Mahanti S, 2013, BRAIN BEHAV IMMUN, V28, P115, DOI 10.1016/j.bbi.2012.11.001
   Maniam J, 2010, PSYCHONEUROENDOCRINO, V35, P1553, DOI 10.1016/j.psyneuen.2010.05.012
   Mawe GM, 2013, NAT REV GASTRO HEPAT, V10, P473, DOI 10.1038/nrgastro.2013.105
   Moratalla A, 2016, J HEPATOL, V64, P135, DOI 10.1016/j.jhep.2015.08.020
   Moratalla A, 2014, LIVER INT, V34, P850, DOI 10.1111/liv.12380
   Morris G, 2017, MOL NEUROBIOL, V54, P4432, DOI 10.1007/s12035-016-0004-2
   Moya-Pérez A, 2017, BRAIN BEHAV IMMUN, V65, P43, DOI 10.1016/j.bbi.2017.05.011
   Moya-Pérez A, 2014, NUTR METAB CARDIOVAS, V24, P57, DOI 10.1016/j.numecd.2013.04.011
   Moya-Pérez A, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0126976
   Needham BL, 2010, AM J PUBLIC HEALTH, V100, P1040, DOI 10.2105/AJPH.2009.172809
   Pan A, 2012, INT J OBESITY, V36, P595, DOI 10.1038/ijo.2011.111
   PORSOLT RD, 1977, ARCH INT PHARMACOD T, V229, P327
   Puig KL, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030378
   Reimann M, 2017, INT J OBESITY, V41, P714, DOI 10.1038/ijo.2017.36
   Sanz Y, 2016, ENCY FOOD HLTH
   Sanz Y, 2014, ADV EXP MED BIOL, V817, P291, DOI 10.1007/978-1-4939-0897-4_14
   Schroeder FA, 2007, BIOL PSYCHIAT, V62, P55, DOI 10.1016/j.biopsych.2006.06.036
   Seibenhener ML, 2015, JOVE-J VIS EXP, DOI 10.3791/52434
   Shadnoush M, 2013, IRAN J PHARM RES, V12, P929
   Sharma A, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012147
   Sharma S, 2013, INT J OBESITY, V37, P382, DOI 10.1038/ijo.2012.48
   Sharma S, 2012, SCI REP-UK, V2, DOI 10.1038/srep00431
   Slyepchenko A, 2017, PSYCHOTHER PSYCHOSOM, V86, P31, DOI 10.1159/000448957
   Spiller R, 2008, NEUROPHARMACOLOGY, V55, P1072, DOI 10.1016/j.neuropharm.2008.07.016
   Stepanichev MY, 2016, ACTA NEUROBIOL EXP, V76, P324, DOI 10.21307/ane-2017-031
   Stetz J, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055967
   Stieg MR, 2015, PSYCHONEUROENDOCRINO, V51, P47, DOI 10.1016/j.psyneuen.2014.09.004
   Tamashiro KLK, 2005, FRONT NEUROENDOCRIN, V26, P27, DOI 10.1016/j.yfrne.2005.03.001
   Tana C, 2010, NEUROGASTROENT MOTIL, V22, P512, DOI 10.1111/j.1365-2982.2009.01427.x
   Tanaka M, 2000, EUR J PHARMACOL, V405, P397, DOI 10.1016/S0014-2999(00)00569-0
   Vogelzangs N, 2014, NEUROPSYCHOPHARMACOL, V39, P1624, DOI 10.1038/npp.2014.9
   Wilkening JL, 2016, ECOL EVOL, V6, P502, DOI 10.1002/ece3.1857
   WILLNER P, 1987, PSYCHOPHARMACOLOGY, V93, P358
   Yamada N, 2011, ENDOCRINOLOGY, V152, P2634, DOI 10.1210/en.2011-0004
   Yang JL, 2016, SCI REP-UK, V6, DOI 10.1038/srep35239
   Yano JM, 2015, CELL, V161, P264, DOI 10.1016/j.cell.2015.02.047
NR 74
TC 63
Z9 69
U1 1
U2 34
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0893-7648
EI 1559-1182
J9 MOL NEUROBIOL
JI Mol. Neurobiol.
PD JUN
PY 2018
VL 55
IS 6
BP 5337
EP 5352
DI 10.1007/s12035-017-0768-z
PG 16
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GF5FI
UT WOS:000431991500064
PM 28921462
DA 2025-06-11
ER

PT J
AU Crosta, ML
   Caldarola, G
   Fraietta, S
   Craba, A
   Benedetti, C
   Coco, V
   Janiri, L
   Rinaldi, L
   De Simone, C
AF Crosta, M. L.
   Caldarola, G.
   Fraietta, S.
   Craba, A.
   Benedetti, C.
   Coco, V.
   Janiri, L.
   Rinaldi, L.
   De Simone, C.
TI Psychopathology and eating disorders in patients with psoriasis
SO GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
LA English
DT Article
DE Psoriasis; Eating disorders; Psychopathology; Obesity
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; DEPRESSION; OBESITY; COMORBIDITIES;
   ASSOCIATION; PREVALENCE; INVENTORY
AB Aim. Psoriasis is a multifactorial chronic inflammatory skin disease that often occurs in patients who are overweight or obese. In literature the connections between obesity and eating disorders are well known, but few studies have investigated the link between eating disorders and psoriasis.
   We hypothesized that Eating Disorders (ED) can be considered a psychogenic cofactors, which contribute to the development of obesity and metabolic syndrome in psoriatic patients, who are frequently prone to psychiatric comorbidity.
   Methods. From January to April 2011 we enrolled 100 consecutive psoriatic outpatients and a control group of 100 selected non-psoriatic outpatients, matched by age, gender, and BMI to the study group. The assessment battery was composed by the Psoriasis Area Severity Index (PASI) score, the Eating Disorder Inventory (EDI) and the Symptom Checklist-90 Revised (SCL-90-R (R)).
   Results. Our data showed that most of EDI and SCL-90R subscales was mostly altered in psoriatic population compared to patients without psoriasis. Moreover, we noticed in patients with psoriasis an association between the progressive weight increase and an impairment on most of EDI subscales.
   Conclusion. Psoriasis is associated with psychopathological traits, which are frequently found in EDs. Since obesity makes psoriasis less susceptible to therapy and weight loss improves drug response, dermatologists should be alert to suspect the presence of this condition.
C1 [Crosta, M. L.; Fraietta, S.; Craba, A.; Janiri, L.; Rinaldi, L.] Univ Cattolica Sacro Cuore, Inst Psychiat, I-00168 Rome, Italy.
   [Caldarola, G.; Benedetti, C.; Coco, V.; De Simone, C.] Univ Cattolica Sacro Cuore, Inst Dermatol, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Caldarola, G (corresponding author), Sacro Cuore Catholic Univ, Dept Dermatol, Lgo F Vito 8, I-00168 Rome, Italy.
EM giacomocaldarola@libero.it
RI Caldarola, Giacomo/K-9676-2016; Coco, Valeria/ACH-1880-2022
OI Caldarola, Giacomo/0000-0002-8837-9232; Coco,
   Valeria/0000-0001-7557-5587; de simone, clara/0000-0002-0898-0045
CR Altunay I, 2011, CLIN COSMET INV DERM, V4, P139, DOI 10.2147/CCID.S24165
   [Anonymous], 2012, Diagnostic and statistical manual of mental disorders, V4th
   Anzieu D, 1987, IO PELLE
   Anzieu D., 1997, INVOLUCRI PSICHICI
   Anzieu D., 1992, EPIDERMIDE NOMADE PE
   Anzieu D., 1996, IO PELLE ALLIO PENSA
   Armstrong AW, 2012, NUTR DIABETES, V2, DOI 10.1038/nutd.2012.26
   Azfar RS, 2008, CURR OPIN RHEUMATOL, V20, P416, DOI 10.1097/BOR.0b013e3283031c99
   Bremmer S, 2010, J AM ACAD DERMATOL, V63, P1058, DOI 10.1016/j.jaad.2009.09.053
   Christophers E, 2007, CLIN DERMATOL, V25, P529, DOI 10.1016/j.clindermatol.2007.08.006
   Dauden E, 2012, Actas Dermosifiliogr, V103 Suppl 1, P1, DOI 10.1016/S0001-7310(12)70001-7
   Derogatis LR, 1977, SCL9OR SCH MED
   Elomaa AP, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-2
   FREDRIKSSON T, 1978, DERMATOLOGICA, V157, P238, DOI 10.1159/000250839
   GARNER DM, 1983, INT J EAT DISORDER, V2, P15, DOI 10.1002/1098-108X(198321)2:2<15::AID-EAT2260020203>3.0.CO;2-6
   Gottlieb AB, 2009, AM J MED, V122, DOI 10.1016/j.amjmed.2009.06.021
   Gupta MA, 2003, AM J CLIN DERMATOL, V4, P833, DOI 10.2165/00128071-200304120-00003
   Hayes J, 2010, DERMATOL THER, V23, P174, DOI 10.1111/j.1529-8019.2010.01312.x
   Kiec-Swierczynska Marta, 2006, Medycyna Pracy, V57, P551
   Kimball AB, 2012, J AM ACAD DERMATOL, V67, P651, DOI 10.1016/j.jaad.2011.11.948
   Kurd SK, 2010, ARCH DERMATOL, V146, P891, DOI 10.1001/archdermatol.2010.186
   Milos G, 2004, CAN J PSYCHIAT, V49, P179, DOI 10.1177/070674370404900305
   Misery L, 2012, ANN DERMATOL VENER, V139, pS53, DOI 10.1016/S0151-9638(12)70111-4
   Paller AS, 2013, JAMA DERMATOL, V149, P166, DOI 10.1001/jamadermatol.2013.1078
   Parafianowicz K, 2010, PSYCHIATR POL, V44, P119
   Rieder E, 2012, INT J DERMATOL, V51, P12, DOI 10.1111/j.1365-4632.2011.05071.x
   Rieger E, 2005, INT J EAT DISORDER, V37, P234, DOI 10.1002/eat.20101
   Russo Paul A J, 2004, Australas J Dermatol, V45, P155, DOI 10.1111/j.1440-0960.2004.00078.x
   Schauenburg H, 1999, PSYCHOTHER PSYCHOSOM, V68, P199, DOI 10.1159/000012333
   Schauenburg H, 1998, PSYCHOTHER PSYCH MED, V48, P257
   Sommer DM, 2006, ARCH DERMATOL RES, V298, P321, DOI 10.1007/s00403-006-0703-z
   Sterry W, 2007, BRIT J DERMATOL, V157, P649, DOI 10.1111/j.1365-2133.2007.08068.x
   Stunkard AJ, 2011, PSYCHIAT CLIN N AM, V34, P765, DOI 10.1016/j.psc.2011.08.010
   Van Voorhees AS, 2009, POSTGRAD MED, V121, P154, DOI 10.3810/pgm.2009.07.2040
   Villarejo C, 2012, EUR EAT DISORD REV, V20, P250, DOI 10.1002/erv.2166
   Wilfley DE, 2003, INT J EAT DISORDER, V34, pS96, DOI 10.1002/eat.10209
NR 36
TC 14
Z9 14
U1 0
U2 4
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0392-0488
EI 1827-1820
J9 GIORN ITAL DERMAT V
JI G. Ital. Dermatol. Venereol.
PD JUN
PY 2014
VL 149
IS 3
BP 355
EP 361
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology
GA AM6YP
UT WOS:000340012200010
PM 24819764
DA 2025-06-11
ER

PT J
AU Astiz, M
   Oster, H
AF Astiz, Mariana
   Oster, Henrik
TI Perinatal Programming of Circadian Clock-Stress Crosstalk
SO NEURAL PLASTICITY
LA English
DT Review
ID PITUITARY-ADRENAL AXIS; PRENATAL RESTRAINT STRESS; EARLY-LIFE STRESS;
   REV-ERB-ALPHA; GENE-EXPRESSION; GLUCOCORTICOID-RECEPTOR; SUPRACHIASMATIC
   NUCLEUS; EMBRYONIC-DEVELOPMENT; METABOLIC SYNDROME; PERIPHERAL CLOCKS
AB An intact communication between circadian clocks and the stress system is important for maintaining physiological homeostasis under resting conditions and in response to external stimuli. There is accumulating evidence for a reciprocal interaction between both-from the systemic to the molecular level. Disruption of this interaction by external factors such as shiftwork, jetlag, or chronic stress increases the risk of developing metabolic, immune, or mood disorders. From experiments in rodents, we know that both systems maturate during the perinatal period. During that time, exogenous factors such as stress or alterations in the external photoperiod may critically affect-or program-physiological functions later in life. This developmental programming process has been attributed to maternal stress signals reaching the embryo, which lastingly change gene expression through the induction of epigenetic mechanisms. Despite the well-known function of the adult circadian system in temporal coordination of physiology and behavior, the role of maternal and embryonic circadian clocks during pregnancy and postnatal development is still poorly defined. A better understanding of the circadian-stress crosstalk at different periods of development may help to improve stress resistance and devise preventive and therapeutic strategies against chronic stress-associated disorders.
C1 [Astiz, Mariana; Oster, Henrik] Univ Lubeck, Ctr Brain Behav & Metab, Inst Neurobiol, Marie Curie St, D-23562 Lubeck, Germany.
C3 University of Lubeck
RP Oster, H (corresponding author), Univ Lubeck, Ctr Brain Behav & Metab, Inst Neurobiol, Marie Curie St, D-23562 Lubeck, Germany.
EM henrik.oster@uksh.de
RI Oster, Henrik/O-4426-2019; Oster, Henrik/D-2335-2013
OI Astiz, Mariana/0000-0001-9912-1686; Oster, Henrik/0000-0002-1414-7068
FU German Research Foundation (DFG) [SFB-134, GRK-1957]; Volkswagen
   Foundation; European Molecular Biology Organization (EMBO);
   International Brain Research Organization (IBRO)
FX The authors thank Drs. C.E. Koch and M.E. Solano for the critical
   revision of the manuscript. This work was supported by grants of the
   German Research Foundation (DFG; SFB-134 and GRK-1957) and the
   Volkswagen Foundation to Henrik Oster and by fellowships of the European
   Molecular Biology Organization (EMBO) and International Brain Research
   Organization (IBRO) to Mariana Astiz.
CR Albrecht U, 2017, FRONT NEUROL, V8, DOI 10.3389/fneur.2017.00030
   Alexander N, 2016, J CLIN ENDOCR METAB, V101, P581, DOI 10.1210/jc.2015-2453
   Alikhani-Koopaei R, 2004, J CLIN INVEST, V114, P1146, DOI 10.1172/JCI200421647
   [Anonymous], 2004, EUR J ENDOCRINOL S3
   Asztalos E, 2012, J NUTR METAB, V2012, DOI 10.1155/2012/930591
   Balsalobre A, 2000, SCIENCE, V289, P2344, DOI 10.1126/science.289.5488.2344
   Barclay JL, 2012, PROG BRAIN RES, V199, P163, DOI 10.1016/B978-0-444-59427-3.00030-7
   Beijers R, 2014, EUR CHILD ADOLES PSY, V23, P943, DOI 10.1007/s00787-014-0566-3
   Borniger JC, 2014, PHYSIOL BEHAV, V133, P99, DOI 10.1016/j.physbeh.2014.05.012
   BRADBURY MJ, 1991, ENDOCRINOLOGY, V128, P680, DOI 10.1210/endo-128-2-680
   Brandon DH, 2002, J PEDIATR-US, V140, P192, DOI 10.1067/mpd.2002.121932
   Brunton PJ, 2015, J NEUROENDOCRINOL, V27, P468, DOI 10.1111/jne.12265
   Burd L, 2004, AM J MED GENET C, V127C, P51, DOI 10.1002/ajmg.c.30016
   Carpentier R, 2008, J NEUROCHEM, V104, P777, DOI 10.1111/j.1471-4159.2007.05055.x
   Chen J, 2012, J NEUROENDOCRINOL, V24, P1055, DOI 10.1111/j.1365-2826.2012.02306.x
   Chen YC, 2008, J NEUROSCI, V28, P2903, DOI 10.1523/JNEUROSCI.0225-08.2008
   Cho K, 2000, J NEUROSCI, V20, part. no.
   Christ E, 2012, PROG BRAIN RES, V199, P105, DOI 10.1016/B978-0-444-59427-3.00006-X
   Chung S, 2014, CELL, V157, P858, DOI 10.1016/j.cell.2014.03.039
   Claustrat B, 2008, HORM METAB RES, V40, P398, DOI 10.1055/s-2008-1065330
   COLE TJ, 1995, GENE DEV, V9, P1608, DOI 10.1101/gad.9.13.1608
   Coleman G, 2017, FRONT NEUROSCI-SWITZ, V11, DOI 10.3389/fnins.2017.00046
   Coleman G, 2016, EUR J NEUROSCI, V44, P2807, DOI 10.1111/ejn.13388
   Conway-Campbell BL, 2010, J NEUROENDOCRINOL, V22, P1093, DOI 10.1111/j.1365-2826.2010.02051.x
   Cottrell EC, 2014, ACTA PHYSIOL, V210, P288, DOI 10.1111/apha.12187
   DALLMAN MF, 1987, RECENT PROG HORM RES, V43, P113
   Darnaudéry M, 2006, NEUROBIOL AGING, V27, P119, DOI 10.1016/j.neurobiolaging.2005.01.008
   de Kloet ER, 2005, NAT REV NEUROSCI, V6, P463, DOI 10.1038/nrn1683
   de Weerth C, 2003, EARLY HUM DEV, V73, P39, DOI 10.1016/S0378-3782(03)00074-4
   Di Segni M., 2017, SEMINARS CE IN PRESS
   Dibner C, 2010, ANNU REV PHYSIOL, V72, P517, DOI 10.1146/annurev-physiol-021909-135821
   Dickmeis T, 2013, MOL CELL ENDOCRINOL, V380, P2, DOI 10.1016/j.mce.2013.05.012
   Dong YL, 2016, HISTOL HISTOPATHOL, V31, P415, DOI 10.14670/HH-11-684
   Dumbell R, 2016, FRONT ENDOCRINOL, V7, DOI 10.3389/fendo.2016.00037
   DUNN J, 1972, AM J PHYSIOL, V223, P402, DOI 10.1152/ajplegacy.1972.223.2.402
   Ehrhart-Bornstein M, 1998, ENDOCR REV, V19, P101, DOI 10.1210/er.19.2.101
   Galliher-Beckley AJ, 2008, MOL CELL BIOL, V28, P7309, DOI 10.1128/MCB.00808-08
   GIBBS FP, 1970, AM J PHYSIOL, V219, P288, DOI 10.1152/ajplegacy.1970.219.2.288
   GOLDMAN L, 1973, NEUROENDOCRINOLOGY, V12, P199, DOI 10.1159/000122169
   Gray JD, 2017, NAT REV ENDOCRINOL, V13, P661, DOI 10.1038/nrendo.2017.97
   GRINO M, 1989, ENDOCRINOLOGY, V124, P60, DOI 10.1210/endo-124-1-60
   Guo HN, 2005, P NATL ACAD SCI USA, V102, P3111, DOI 10.1073/pnas.0409734102
   Hampp G, 2008, CURR BIOL, V18, P678, DOI 10.1016/j.cub.2008.04.012
   HOLMES MC, 1995, MOL BRAIN RES, V28, P186, DOI 10.1016/0169-328X(94)00207-U
   Hoshino K, 2006, ENDOCRINOLOGY, V147, P1916, DOI 10.1210/en.2005-1343
   Huang CCJ, 2012, ENDOCRINOLOGY, V153, P4749, DOI 10.1210/en.2012-1258
   Hulshof HJ, 2011, BEHAV BRAIN RES, V216, P552, DOI 10.1016/j.bbr.2010.08.038
   Husse J, 2015, BIOESSAYS, V37, P1119, DOI 10.1002/bies.201500026
   Husse J, 2014, FASEB J, V28, P4950, DOI 10.1096/fj.14-256594
   Ishida A, 2005, CELL METAB, V2, P297, DOI 10.1016/j.cmet.2005.09.009
   Ivy AS, 2008, NEUROSCIENCE, V154, P1132, DOI 10.1016/j.neuroscience.2008.04.019
   Jin LZ, 2004, J OCCUP ENVIRON MED, V46, P1144, DOI 10.1097/01.jom.0000145168.21614.21
   Joëls M, 2004, ANN NY ACAD SCI, V1032, P301, DOI 10.1196/annals.1314.046
   Joseph V, 2002, J PHYSIOL-LONDON, V543, P387, DOI 10.1113/jphysiol.2002.022236
   Jud C, 2006, J BIOL RHYTHM, V21, P149, DOI [10.1177/0748730406286264, 10.1177/0748730405286264]
   Kabrita CS, 2008, BRAIN RES, V1195, P20, DOI 10.1016/j.brainres.2007.12.020
   Kalsbeek A, 2003, J NEUROENDOCRINOL, V15, P1144, DOI 10.1111/j.1365-2826.2003.01112.x
   Kaneshi Y, 2016, SCI REP-UK, V6, DOI 10.1038/srep21680
   Karlsson B, 2001, OCCUP ENVIRON MED, V58, P747, DOI 10.1136/oem.58.11.747
   Khashan AS, 2008, ARCH GEN PSYCHIAT, V65, P146, DOI 10.1001/archgenpsychiatry.2007.20
   Kiessling S, 2010, J CLIN INVEST, V120, P2600, DOI 10.1172/JCI41192
   Koch CE, 2017, NEUROBIOL STRESS, V6, P57, DOI 10.1016/j.ynstr.2016.09.001
   Koch CE, 2016, J ENDOCRINOL, V231, P209, DOI 10.1530/JOE-16-0163
   Koehl M, 2000, BRAIN RES, V882, P196, DOI 10.1016/S0006-8993(00)02803-1
   Kolber BJ, 2008, STRESS, V11, P321, DOI 10.1080/10253890701821081
   Lamia KA, 2008, P NATL ACAD SCI USA, V105, P15172, DOI 10.1073/pnas.0806717105
   Lamia KA, 2011, NATURE, V480, P552, DOI 10.1038/nature10700
   Landgraf D, 2015, CHRONOBIOL INT, V32, P416, DOI 10.3109/07420528.2014.986576
   Landgraf D, 2014, FRONT NEUROANAT, V8, DOI 10.3389/fnana.2014.00143
   Lee JJ, 2005, J STEROID BIOCHEM, V96, P31, DOI 10.1016/j.jsbmb.2005.01.026
   Lee JH, 2007, NEUROSCI RES, V58, P32, DOI 10.1016/j.neures.2007.01.008
   LeGates TA, 2012, NATURE, V491, P594, DOI 10.1038/nature11673
   Leliavski A, 2014, ENDOCRINOLOGY, V155, P133, DOI 10.1210/en.2013-1531
   Lesage J, 2004, J ENDOCRINOL, V181, P291, DOI 10.1677/joe.0.1810291
   Levi F, 2007, ANNU REV PHARMACOL, V47, P593, DOI 10.1146/annurev.pharmtox.47.120505.105208
   LEVINE S, 1994, ANN NY ACAD SCI, V746, P275, DOI 10.1111/j.1749-6632.1994.tb39245.x
   LEWY AJ, 1987, SCIENCE, V235, P352, DOI 10.1126/science.3798117
   Maccari S, 2007, PSYCHONEUROENDOCRINO, V32, pS10, DOI 10.1016/j.psyneuen.2007.06.005
   Mairesse Jerome, 2015, Adv Neurobiol, V10, P27, DOI 10.1007/978-1-4939-1372-5_2
   Mairesse J, 2013, INT J NEUROPSYCHOPH, V16, P323, DOI 10.1017/S1461145711001970
   Meaney MJ, 2000, J NEUROSCI, V20, P3926, DOI 10.1523/JNEUROSCI.20-10-03926.2000
   Mendez N, 2016, ENDOCRINOLOGY, V157, P4654, DOI 10.1210/en.2016-1282
   MEYER JS, 1983, EXP NEUROL, V82, P432, DOI 10.1016/0014-4886(83)90415-6
   Moisiadis VG, 2014, NAT REV ENDOCRINOL, V10, P391, DOI 10.1038/nrendo.2014.73
   Morley-Fletcher S, 2003, BRAIN RES, V989, P246, DOI 10.1016/S0006-8993(03)03293-1
   Nader N, 2010, TRENDS ENDOCRIN MET, V21, P277, DOI 10.1016/j.tem.2009.12.011
   Nader N, 2009, FASEB J, V23, P1572, DOI 10.1096/fj.08-117697
   Navailles S, 2010, DEV NEUROSCI-BASEL, V32, P139, DOI 10.1159/000293989
   Nicolaides NC, 2014, ANN NY ACAD SCI, V1318, P71, DOI 10.1111/nyas.12464
   O'Connor TG, 2005, BIOL PSYCHIAT, V58, P211, DOI 10.1016/j.biopsych.2005.03.032
   Ohta H, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002601
   Oishi K, 2005, DNA RES, V12, P191, DOI 10.1093/dnares/dsi003
   Okabe T, 2016, J CELL SCI, V129, P4143, DOI 10.1242/jcs.190959
   Okatani Y, 1998, J PINEAL RES, V25, P129, DOI 10.1111/j.1600-079X.1998.tb00550.x
   Opperhuizen AL, 2015, FRONT PHARMACOL, V6, DOI 10.3389/fphar.2015.00050
   Oster H, 2006, CELL METAB, V4, P163, DOI 10.1016/j.cmet.2006.07.002
   Pezük P, 2012, ENDOCRINOLOGY, V153, P4775, DOI 10.1210/en.2012-1486
   Rakers F., 2017, NEUROSCIENC IN PRESS
   RALPH MR, 1990, SCIENCE, V247, P975, DOI 10.1126/science.2305266
   Reddy AB, 2007, HEPATOLOGY, V45, P1478, DOI 10.1002/hep.21571
   REPPERT SM, 1983, SCIENCE, V220, P969, DOI 10.1126/science.6844923
   Roberts D, 2017, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004454.pub3
   Ryan J, 2017, EPIGENOMICS-UK, V9, P313, DOI 10.2217/epi-2016-0118
   Santarelli S, 2017, PSYCHONEUROENDOCRINO, V78, P213, DOI 10.1016/j.psyneuen.2017.01.021
   Sapolsky RM, 2000, ENDOCR REV, V21, P55, DOI 10.1210/er.21.1.55
   Schibler U, 2003, J BIOL RHYTHM, V18, P250, DOI 10.1177/0748730403018003007
   Schmidt M, 2003, INT J DEV NEUROSCI, V21, P125, DOI 10.1016/S0736-5748(03)00030-3
   Seckl JR, 2007, PROG BRAIN RES, V167, P17, DOI 10.1016/S0079-6123(07)67002-2
   Sekaran S, 2005, CURR BIOL, V15, P1099, DOI 10.1016/j.cub.2005.05.053
   Seron-Ferre Maria, 2007, Birth Defects Research, V81, P204, DOI 10.1002/bdrc.20101
   Shearman LP, 2001, J BIOL RHYTHM, V16, P531, DOI 10.1177/074873001129002222
   Sickmann H. M., 2017, J DEV ORIG HLTH DIS, V29, P1
   Simons SSH, 2015, PSYCHONEUROENDOCRINO, V62, P292, DOI 10.1016/j.psyneuen.2015.08.024
   Smarr BL, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-03406-4
   So AYL, 2009, P NATL ACAD SCI USA, V106, P17582, DOI 10.1073/pnas.0909733106
   Son GH, 2008, P NATL ACAD SCI USA, V105, P20970, DOI 10.1073/pnas.0806962106
   STANTON ME, 1990, DEV PSYCHOBIOL, V23, P411, DOI 10.1002/dev.420230504
   Sumová A, 2006, CHRONOBIOL INT, V23, P237, DOI 10.1080/07420520500522523
   Surjit M, 2011, CELL, V145, P224, DOI 10.1016/j.cell.2011.03.027
   Tahara Y, 2017, J PHYSIOL SCI, V67, P1, DOI 10.1007/s12576-016-0450-7
   Tahara Y, 2015, SCI REP-UK, V5, DOI 10.1038/srep11417
   Takabe S, 2008, ARCH BIOCHEM BIOPHYS, V475, P1, DOI 10.1016/j.abb.2008.03.036
   Thomas L, 2002, J PINEAL RES, V33, P218, DOI 10.1034/j.1600-079X.2002.02921.x
   TORRELLAS A, 1981, PHYSIOL BEHAV, V26, P129, DOI 10.1016/0031-9384(81)90088-3
   Torres-Farfan C, 2006, ENDOCRINOLOGY, V147, P4618, DOI 10.1210/en.2006-0628
   Tractenberg SG, 2016, NEUROSCI BIOBEHAV R, V68, P489, DOI 10.1016/j.neubiorev.2016.06.021
   Tsang AH, 2017, FRONT ENDOCRINOL, V8, DOI 10.3389/fendo.2017.00027
   Turek FW, 2005, SCIENCE, V308, P1043, DOI 10.1126/science.1108750
   Tzanoulinou S, 2017, CURR TOP BEHAV NEURO, V30, P411, DOI 10.1007/7854_2015_430
   UGRUMOV MV, 1991, INT REV CYTOL, V129, P207
   Van Waes V, 2006, EUR J NEUROSCI, V24, P1193, DOI 10.1111/j.1460-9568.2006.04973.x
   Varcoe TJ, 2016, CHRONOBIOL INT, V33, P1171, DOI 10.1080/07420528.2016.1207661
   Varcoe TJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0053800
   Vetter C, 2017, CURR BIOL, V27, pR656, DOI 10.1016/j.cub.2017.05.057
   Voiculescu SE, 2016, BRAIN RES, V1650, P51, DOI 10.1016/j.brainres.2016.08.031
   WALKER CD, 1986, ENDOCRINOLOGY, V119, P1816, DOI 10.1210/endo-119-4-1816
   Wan QR, 2014, BEHAV BRAIN RES, V271, P1, DOI 10.1016/j.bbr.2014.05.031
   Weaver ICG, 2004, NAT NEUROSCI, V7, P847, DOI 10.1038/nn1276
   Wharfe MD, 2011, ENDOCRINOLOGY, V152, P3552, DOI 10.1210/en.2011-0081
   Wood CE, 2016, COMPR PHYSIOL, V6, P33, DOI 10.1002/cphy.c150005
   Wood CE, 2013, CLIN OBSTET GYNECOL, V56, P610, DOI 10.1097/GRF.0b013e31829e5b15
   Wu YH, 2014, ENDOCRINOLOGY, V155, P1751, DOI 10.1210/en.2013-1868
   Wyrwoll CS, 2009, ENDOCRINOLOGY, V150, P1287, DOI 10.1210/en.2008-1100
   Yang ST, 2009, ENDOCRINOLOGY, V150, P2153, DOI 10.1210/en.2008-0705
   Yeh TF, 2004, NEW ENGL J MED, V350, P1304, DOI 10.1056/NEJMoa032089
   Yoo SH, 2004, P NATL ACAD SCI USA, V101, P5339, DOI 10.1073/pnas.0308709101
   Zhang R, 2014, P NATL ACAD SCI USA, V111, P16219, DOI 10.1073/pnas.1408886111
NR 147
TC 22
Z9 25
U1 0
U2 13
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2090-5904
EI 1687-5443
J9 NEURAL PLAST
JI Neural. Plast.
PY 2018
VL 2018
AR 5689165
DI 10.1155/2018/5689165
PG 12
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA FW6JD
UT WOS:000425423400001
PM 29593783
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Lynskey, SJ
   Ling, ZH
   Ziemann, M
   Gill, SD
   McGee, SL
   Page, RS
AF Lynskey, Samuel J.
   Ling, Zihui
   Ziemann, Mark
   Gill, Stephen D.
   McGee, Sean L.
   Page, Richard S.
TI Loosening the Lid on Shoulder Osteoarthritis: How the Transcriptome and
   Metabolic Syndrome Correlate with End-Stage Disease
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE transcriptomic analysis; metabolic syndrome; OA; cuff-tear arthropathy;
   rotator cuff arthropathy; ageing
ID KNEE OSTEOARTHRITIS; OSTEOGENIC DIFFERENTIATION; ARTICULAR CHONDROCYTES;
   PLASMA ADIPONECTIN; POSSIBLE MECHANISM; OXIDATIVE STRESS; CROSS-LINKING;
   JOINT DISEASE; STEM-CELL; CARTILAGE
AB Metabolic syndrome (MetS) associated with Osteoarthritis (OA) is an increasingly recognised entity. Whilst the degenerative pattern in cuff-tear arthropathy (CTA) has been well documented, the biological processes behind primary shoulder OA and CTA remain less understood. This study investigates transcriptomic differences in these conditions, alongside the impact of MetS in patients undergoing total shoulder replacement. In a multi-centre study, 20 OA patients undergoing total shoulder replacement were included based on specific treatment indications for OA and cuff-tear arthropathy as well as 25 patients undergoing rotator cuff repair (RCR) as a comparator group. Tissues from subchondral bone, capsule (OA and RCR), and synovium were biopsied, and RNA sequencing was performed using Illumina platforms. Differential gene expression was conducted using DESeq2, adjusting for demographic factors, followed by pathway enrichment using the mitch package. Gene expressions in CTA and primary OA was differentially affected. CTA showed mitochondrial dysfunction, GATD3A downregulation, and increased cartilage degradation, while primary OA was marked by upregulated inflammatory and catabolic pathways. The effect of MetS on these pathologies was further shown. MetS further disrupted WNT/beta-catenin signalling in CTA, and in OA. Genes such as ACAN, PANX3, CLU, and VAT1L were upregulated, highlighting potential biomarkers for early OA detection. This transcriptomic analysis reveals key differences between end-stage CTA and primary glenohumeral OA. CTA shows heightened metabolic/protein synthesis activity with less immune-driven inflammation. Under MetS, mitochondrial dysfunction (including GATD3A downregulation) and altered Wnt/beta-catenin signalling intensify cartilage and bone damage. In contrast, primary OA features strong complement activation, inflammatory gene expression, and collagen remodelling. MetS worsens both conditions via oxidative stress, advanced glycation end products, and ECM disruption-particularly, increased CS/DS degradation. These distinctions support targeted treatments, from antioxidants and Wnt modulators to aggrecanase inhibitors or clusterin augmentation. Addressing specific molecular disruptions, especially those amplified by MetS, may preserve shoulder function, delay surgical intervention, and improve long-term patient outcomes.
C1 [Lynskey, Samuel J.; Gill, Stephen D.; Page, Richard S.] Geelong Univ Hosp, Dept Orthopaed Surg, Geelong, Vic 3220, Australia.
   [Lynskey, Samuel J.; McGee, Sean L.] Deakin Univ, Fac Hlth, Sch Med, Geelong, Vic 3220, Australia.
   [Ling, Zihui] Peninsula Hlth, 2 Hastings Rd, Frankston, Vic 3199, Australia.
   [Ziemann, Mark] Burnet Inst, Melbourne, Vic 3004, Australia.
   [Ziemann, Mark] Deakin Univ, Sch Life & Environm Sci, Pigdons Rd, Geelong, Vic 3216, Australia.
   [Gill, Stephen D.; Page, Richard S.] St John God Hosp, Barwon Ctr Orthopaed Res & Educ BCORE, Geelong, Vic 3220, Australia.
   [Gill, Stephen D.; Page, Richard S.] Deakin Univ, IMPACT Inst Mental & Phys Hlth & Clin Translat, Barwon Hlth, Geelong, Vic 3220, Australia.
C3 Barwon Health; Geelong Hospital; Deakin University; Peninsula Health;
   Burnet Institute; Deakin University; St John of God Health Care; Deakin
   University; Barwon Health
RP Lynskey, SJ (corresponding author), Geelong Univ Hosp, Dept Orthopaed Surg, Geelong, Vic 3220, Australia.; Lynskey, SJ (corresponding author), Deakin Univ, Fac Hlth, Sch Med, Geelong, Vic 3220, Australia.
EM slynskey@deakin.edu.au
RI Page, Richard/K-6327-2015; Ziemann, Mark/ADY-8719-2022; Gill,
   Stephen/AFH-8626-2022
OI Gill, Stephen/0000-0001-8722-0572
FU Australian Orthopaedic Association Research Foundation (AOARF);  [I.D.:
   25-Reg]
FX Funding support for this work was obtained from the Australian
   Orthopaedic Association Research Foundation (AOARF), Grant I.D.: 25-Reg.
CR Abed É, 2011, ARTHRITIS RHEUM-US, V63, P3865, DOI 10.1002/art.30625
   Abramson SB, 2004, J RHEUMATOL, V31, P70, DOI 10.1097/BOR.0b013e328349c2b1
   Adamczyk M, 2017, AMINO ACIDS, V49, P625, DOI 10.1007/s00726-016-2305-1
   Aleem AW, 2023, J BONE JOINT SURG AM, V105, P990, DOI 10.2106/JBJS.22.01124
   Alikhani M, 2007, BONE, V40, P345, DOI 10.1016/j.bone.2006.09.011
   Alvarez-Garcia O, 2016, OSTEOARTHR CARTILAGE, V24, P1639, DOI 10.1016/j.joca.2016.04.015
   Alvarez-Garcia O, 2017, ARTHRITIS RHEUMATOL, V69, P1418, DOI 10.1002/art.40104
   Ansari MY, 2020, J CELL SCI, V133, DOI 10.1242/jcs.247353
   Assirelli E, 2016, OSTEOARTHR CARTILAGE, V24, pS383, DOI 10.1016/j.joca.2016.01.686
   Bar Oz M, 2016, AGING CELL, V15, P499, DOI 10.1111/acel.12456
   Bay-Jensen AC, 2022, CURR OPIN RHEUMATOL, V34, P54, DOI 10.1097/BOR.0000000000000845
   Bhatti JS, 2017, BBA-MOL BASIS DIS, V1863, P1066, DOI 10.1016/j.bbadis.2016.11.010
   Bihlet AR, 2024, ACR OPEN RHEUMATOL, V6, P205, DOI 10.1002/acr2.11610
   Blanco FJ, 2018, NAT REV RHEUMATOL, V14, P327, DOI 10.1038/s41584-018-0001-0
   Bray NL, 2016, NAT BIOTECHNOL, V34, P525, DOI 10.1038/nbt.3519
   Casagrande D, 2015, J SHOULDER ELB SURG, V24, P382, DOI 10.1016/j.jse.2014.11.039
   Chapman K, 2012, BONE, V51, P258, DOI 10.1016/j.bone.2011.11.026
   Chen JN, 2023, GENES DIS, V10, P2097, DOI 10.1016/j.gendis.2022.12.016
   Chen Q, 2021, OPEN MED-WARSAW, V16, P540, DOI 10.1515/med-2021-0241
   Chen X, 2020, J GENE MED, V22, DOI 10.1002/jgm.3231
   Choi WS, 2019, NATURE, V566, P254, DOI 10.1038/s41586-019-0920-1
   Clevers H, 2012, CELL, V149, P1192, DOI 10.1016/j.cell.2012.05.012
   Coenye T, 2021, BIOFILM, V3, DOI 10.1016/j.bioflm.2021.100043
   Coltell O, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020541
   Connor JR, 2001, OSTEOARTHR CARTILAGE, V9, P727, DOI 10.1053/joca.2001.0475
   Courties A, 2015, OSTEOARTHR CARTILAGE, V23, P1955, DOI 10.1016/j.joca.2015.05.016
   Cuffaro D, 2022, J MED CHEM, V65, P13505, DOI 10.1021/acs.jmedchem.2c01177
   Cui D, 2014, ONCOGENE, V33, P2225, DOI 10.1038/onc.2013.170
   Dalmao-Fernández A, 2021, CYTOTHERAPY, V23, P399, DOI 10.1016/j.jcyt.2020.08.010
   Dayal AA, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21218122
   de Boer TN, 2012, OSTEOARTHR CARTILAGE, V20, P846, DOI 10.1016/j.joca.2012.05.002
   Deshmukh V, 2018, OSTEOARTHR CARTILAGE, V26, P18, DOI 10.1016/j.joca.2017.08.015
   Drygalski K, 2023, DIABETES, V72, P159, DOI 10.2337/db22-0676
   Dubin RL, 2001, BONE, V28, P617, DOI 10.1016/S8756-3282(01)00463-X
   Eajazi A, 2015, AM J ROENTGENOL, V205, pW502, DOI 10.2214/AJR.14.13815
   Eaton CB, 2013, OSTEOARTHR CARTILAGE, V21, pS165, DOI 10.1016/j.joca.2013.02.354
   Ewels P, 2016, BIOINFORMATICS, V32, P3047, DOI 10.1093/bioinformatics/btw354
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Fernández-Moreno M, 2008, CURR GENOMICS, V9, P542, DOI 10.2174/138920208786847953
   Frankish A, 2021, NUCLEIC ACIDS RES, V49, pD916, DOI 10.1093/nar/gkaa1087
   Fu GK, 2014, P NATL ACAD SCI USA, V111, P1891, DOI 10.1073/pnas.1323732111
   Geng N, 2022, ANN RHEUM DIS, V81, P1161, DOI 10.1136/annrheumdis-2022-eular.4384
   Geyer M, 2009, OSTEOARTHR CARTILAGE, V17, P328, DOI 10.1016/j.joca.2008.07.010
   Gillespie M, 2022, NUCLEIC ACIDS RES, V50, pD687, DOI 10.1093/nar/gkab1028
   Giordano R, 2020, CLIN J PAIN, V36, P229, DOI 10.1097/AJP.0000000000000804
   Grotle M, 2008, BMC MUSCULOSKEL DIS, V9, DOI 10.1186/1471-2474-9-132
   Gupta A, 2014, BMC MUSCULOSKEL DIS, V15, DOI 10.1186/1471-2474-15-425
   Haasper C, 2008, EXP TOXICOL PATHOL, V59, P355, DOI [10.1016/j.etp.2007.11.013, 10.1016/j.etp.2007.11.008]
   Hacking C.Y.J., 2015, Rotator Cuff Tear Arthropathy: Radiopaedia.org
   HAMADA K, 1990, CLIN ORTHOP RELAT R, P92
   Hamada K, 2011, CLIN ORTHOP RELAT R, V469, P2452, DOI 10.1007/s11999-011-1896-9
   Han YH, 2016, BIOCHEM BIOPH RES CO, V478, P683, DOI 10.1016/j.bbrc.2016.08.007
   Hao H, 2021, ARTHRITIS RES THER, V23, DOI 10.1186/s13075-021-02682-w
   Hattori K, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-94938-3
   Hoffmann BR, 2017, ARTERIOSCL THROM VAS, V37, P433, DOI 10.1161/ATVBAHA.116.307787
   Hu KZ, 2017, BIOMED PHARMACOTHER, V91, P841, DOI 10.1016/j.biopha.2017.04.094
   Inoue D, 2004, J BIOL CHEM, V279, P49795, DOI 10.1074/jbc.M404096200
   Ishikawa M, 2017, J DENT RES, V96, P372, DOI 10.1177/0022034516678203
   Jeffries MA, 2019, OSTEOARTHR CARTILAGE, V27, P371, DOI 10.1016/j.joca.2018.10.004
   Jiang HS, 2014, BMC BIOINFORMATICS, V15, DOI 10.1186/1471-2105-15-182
   Jin QM, 2023, ARTHRITIS RES THER, V25, DOI 10.1186/s13075-023-03011-z
   Kacso IM, 2012, SCAND J CLIN LAB INV, V72, P333, DOI 10.3109/00365513.2012.668928
   Kalvaityte U, 2022, J ORTHOP TRANSL, V32, P77, DOI 10.1016/j.jot.2021.10.001
   Karlsen TA, 2014, STEM CELLS DEV, V23, P290, DOI 10.1089/scd.2013.0209
   Kaspi A, 2020, BMC GENOMICS, V21, DOI 10.1186/s12864-020-06856-9
   Kaur G, 2022, GLYCOBIOLOGY, V32, P720, DOI 10.1093/glycob/cwac029
   Kawatsu M, 2021, BONE, V149, DOI 10.1016/j.bone.2021.115969
   Khan NM, 2018, FREE RADICAL BIO MED, V116, P159, DOI 10.1016/j.freeradbiomed.2018.01.013
   Kim JH, 2015, P NATL ACAD SCI USA, V112, P9424, DOI 10.1073/pnas.1505700112
   Kim KA, 2006, CELL CYCLE, V5, P23, DOI 10.4161/cc.5.1.2305
   Kim P, 2022, NAT COMMUN, V13, DOI 10.1038/s41467-022-31697-3
   Kluzek S, 2015, BRIT MED BULL, V115, P111, DOI 10.1093/bmb/ldv028
   Ko JY, 2024, BIOMED J, V47, DOI 10.1016/j.bj.2023.100629
   Kovács B, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20184653
   Kovacs P, 2023, FRONT IMMUNOL, V14, DOI 10.3389/fimmu.2023.1103097
   Krakowski P, 2024, HEALTHCARE-BASEL, V12, DOI 10.3390/healthcare12161648
   Laurberg TB, 2009, J RHEUMATOL, V36, P1885, DOI 10.3899/jrheum.080907
   Leask M, 2019, FRONT GENET, V9, DOI 10.3389/fgene.2018.00733
   Lee H, 2021, AGING-US, V13, P4881, DOI 10.18632/aging.202617
   Lenihan CR, 2013, BIOCHEM SOC T, V41, P657, DOI 10.1042/BST20120345
   Li DD, 2021, CLIN EPIGENETICS, V13, DOI 10.1186/s13148-021-01096-4
   Liu F, 2023, J ORTHOP SURG RES, V18, DOI 10.1186/s13018-023-03656-1
   Liu GQ, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.893301
   Loeser RF, 2009, OSTEOARTHR CARTILAGE, V17, P971, DOI 10.1016/j.joca.2009.03.002
   Loughlin J, 2004, P NATL ACAD SCI USA, V101, P9757, DOI 10.1073/pnas.0403456101
   Loughlin J, 2015, CURR OPIN RHEUMATOL, V27, P284, DOI 10.1097/BOR.0000000000000171
   Love MI, 2014, GENOME BIOL, V15, DOI 10.1186/s13059-014-0550-8
   Lu JF, 2020, PHARMAZIE, V75, P500, DOI 10.1691/ph.2020.0591
   Lu YH, 2023, J TRANSL MED, V21, DOI 10.1186/s12967-023-04173-9
   Lui KY, 2017, BMC CANCER, V17, DOI 10.1186/s12885-017-3628-3
   Luo Y, 2024, BONE RES, V12, DOI 10.1038/s41413-024-00334-8
   Lynskey SJ, 2024, BMC RES NOTES, V17, DOI 10.1186/s13104-024-07035-9
   Ma BC, 2020, BIOCHEM BIOPH RES CO, V524, P163, DOI 10.1016/j.bbrc.2020.01.060
   Ma Q, 2013, ANNU REV PHARMACOL, V53, P401, DOI 10.1146/annurev-pharmtox-011112-140320
   Ma YH, 2018, INT J MOL MED, V42, P61, DOI 10.3892/ijmm.2018.3587
   Mahjoub S, 2012, CASP J INTERN MED, V3, P386
   Maldonado M, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/284873
   Mao XJ, 2020, FRONT MED-LAUSANNE, V7, DOI 10.3389/fmed.2020.581402
   Masenga SK, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24097898
   Meurot C, 2022, J ORTHOP TRANSL, V32, P121, DOI 10.1016/j.jot.2022.02.001
   Moon PM, 2021, ARTHRITIS RHEUMATOL, V73, P1178, DOI 10.1002/art.41651
   Moon PM, 2015, J MOL MED, V93, P845, DOI 10.1007/s00109-015-1311-1
   Mucientes A, 2020, ANN RHEUM DIS, V79, P1334, DOI 10.1136/annrheumdis-2020-eular.4569
   Mucientes A, 2020, ARTHRITIS RHEUMATOL, V72
   Nagase H, 2003, ARTHRITIS RES THER, V5, P94, DOI 10.1186/ar630
   Nalesso G, 2017, ANN RHEUM DIS, V76, P218, DOI 10.1136/annrheumdis-2015-208577
   Nishikawa K, 2010, J CLIN INVEST, V120, P3455, DOI 10.1172/JCI42528
   Nong SQ, 2021, BIOMED RES INT, V2021, DOI 10.1155/2021/9972011
   Onkarappa RS, 2020, INDIAN J ORTHOP, V54, P20, DOI 10.1007/s43465-020-00145-z
   Page RS, 2019, BMC MUSCULOSKEL DIS, V20, DOI 10.1186/s12891-019-2536-x
   Pang K, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-13852-5
   Puenpatom RA, 2009, POSTGRAD MED, V121, P9, DOI 10.3810/pgm.2009.11.2073
   Pulkkinen L., 2010, INT J PEPT PROT RES, V2010, P248948, DOI [10.1155/2010/248948, DOI 10.1155/2010/248948]
   Qu RZ, 2018, FASEB J, V32, P1044, DOI 10.1096/fj.201700265R
   Quicke JG, 2022, OSTEOARTHR CARTILAGE, V30, P196, DOI 10.1016/j.joca.2021.10.003
   Rajasekaran S, 2022, SPINE J, V22, P19, DOI 10.1016/j.spinee.2021.07.003
   Reynard LN, 2020, OSTEOARTHR CARTILAGE, V28, P275, DOI 10.1016/j.joca.2019.11.010
   Roughley Peter J, 2014, J Exp Orthop, V1, P8, DOI 10.1186/s40634-014-0008-7
   Schneider CV, 2021, MED-CAMBRIDGE, V2, P851, DOI 10.1016/j.medj.2021.04.011
   Schubert T, 2010, EXP MOL MED, V42, P166, DOI 10.3858/emm.2010.42.3.017
   Sharma L, 2021, NEW ENGL J MED, V384, P51, DOI 10.1056/NEJMcp1903768
   Shkhyan R, 2018, ANN RHEUM DIS, V77, P760, DOI 10.1136/annrheumdis-2017-212037
   Shu LL, 2022, BLOOD, V140, P12466, DOI 10.1182/blood-2022-169581
   Simon A., A Quality Control Analysis Tool for High Throughput Sequencing Data
   Simonaro CM, 2008, AM J PATHOL, V172, P112, DOI 10.2353/ajpath.2008.070564
   Simonaro CM, 2001, LAB INVEST, V81, P1319, DOI 10.1038/labinvest.3780345
   Smith AJ, 2022, BMC BIOL, V20, DOI 10.1186/s12915-022-01267-6
   Song ZM, 2021, FRONT CELL DEV BIOL, V9, DOI 10.3389/fcell.2021.786546
   Steinberg J, 2021, ANN RHEUM DIS, V80, P1070, DOI 10.1136/annrheumdis-2020-219760
   Sun K, 2017, CANCER LETT, V388, P198, DOI 10.1016/j.canlet.2016.12.004
   Svensson KJ, 2008, CANCER RES, V68, P9291, DOI 10.1158/0008-5472.CAN-08-2340
   Tang CH, 2007, J IMMUNOL, V179, P5483, DOI 10.4049/jimmunol.179.8.5483
   Tang ZF, 2024, MOL CELL BIOCHEM, V479, P2323, DOI 10.1007/s11010-023-04842-9
   Tarquini C, 2020, AGING-US, V12, P10129, DOI 10.18632/aging.103310
   Tashjian RZ, 2020, ORTHOP J SPORTS MED, V8, DOI 10.1177/2325967120927480
   Thornalley Paul J., 2008, Drug Metabolism and Drug Interactions, V23, P125
   Tong KM, 2011, J CELL BIOCHEM, V112, P1431, DOI 10.1002/jcb.23059
   Tootsi K, 2016, INT J RHEUMATOL, V2016, DOI 10.1155/2016/6402963
   Tscheudschilsuren G, 2006, EXP CELL RES, V312, P63, DOI 10.1016/j.yexcr.2005.09.017
   Ungsudechachai T, 2024, CTS-CLIN TRANSL SCI, V17, DOI 10.1111/cts.13881
   Ungsudechachai T, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-14295-7
   Ungsudechachai T, 2021, CARTILAGE, V13, p1557S, DOI 10.1177/1947603520958149
   Usami Y, 2016, LAB INVEST, V96, P186, DOI 10.1038/labinvest.2015.142
   van der Crabben SN, 2016, J CLIN INVEST, V126, P2881, DOI 10.1172/JCI82890
   van der Kraan PM, 2012, OSTEOARTHR CARTILAGE, V20, P223, DOI 10.1016/j.joca.2011.12.003
   Verzijl N, 2002, ARTHRITIS RHEUM, V46, P114, DOI 10.1002/1529-0131(200201)46:1<114::AID-ART10025>3.0.CO;2-P
   VONDERMARK K, 1992, ARTHRITIS RHEUM-US, V35, P806, DOI 10.1002/art.1780350715
   Wallace IJ, 2017, P NATL ACAD SCI USA, V114, P9332, DOI 10.1073/pnas.1703856114
   Wang GL, 2022, ASIAN BIOMED, V16, P169, DOI 10.2478/abm-2022-0021
   Wang MN, 2011, ANN NY ACAD SCI, V1240, P61, DOI 10.1111/j.1749-6632.2011.06258.x
   Wang X, 2015, OSTEOARTHR CARTILAGE, V23, P22, DOI 10.1016/j.joca.2014.10.002
   Wang YD, 2019, CELL COMMUN SIGNAL, V17, DOI 10.1186/s12964-019-0411-x
   Wen CY, 2012, OSTEOARTHR CARTILAGE, V20, P916, DOI 10.1016/j.joca.2012.04.018
   Whitehead JP, 2006, DIABETES OBES METAB, V8, P264, DOI 10.1111/j.1463-1326.2005.00510.x
   Won Y, 2021, ARTHRITIS RHEUMATOL, V73, P1451, DOI 10.1002/art.41679
   Xin LJ, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1151691
   Xu JW, 2022, BMC MUSCULOSKEL DIS, V23, DOI 10.1186/s12891-022-05453-z
   Xue JF, 2017, BIOMED PHARMACOTHER, V89, P1252, DOI 10.1016/j.biopha.2017.01.130
   Yang B, 2020, ANN PALLIAT MED, V9, P1896, DOI 10.21037/apm-20-929
   Yazici Y, 2019, OSTEOARTHR CARTILAGE, V27, pS503, DOI 10.1016/j.joca.2019.02.566
   Yu SQ, 2020, ONCOTARGETS THER, V13, P709, DOI 10.2147/OTT.S223304
   Yu WM, 2013, CELL STEM CELL, V12, P62, DOI 10.1016/j.stem.2012.11.022
   Zhang CY, 2014, MOL MED REP, V10, P82, DOI 10.3892/mmr.2014.2201
   Zhang SW, 2014, DEVELOPMENT, V141, P4794, DOI 10.1242/dev.115691
   Zheng X, 2023, EXP THER MED, V25, DOI 10.3892/etm.2023.11876
   Zhou YC, 2017, CURR RHEUMATOL REP, V19, DOI 10.1007/s11926-017-0679-z
   Zhu HJ, 2020, COMPUT MATH METHOD M, V2020, DOI 10.1155/2020/9602016
   Zhu ZY, 2020, ARCH MED SCI, V16, P898, DOI 10.5114/aoms.2020.95667
   Zhuo Q, 2012, NAT REV RHEUMATOL, V8, P729, DOI 10.1038/nrrheum.2012.135
NR 169
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR 28
PY 2025
VL 26
IS 7
AR 3145
DI 10.3390/ijms26073145
PG 32
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 1FO7J
UT WOS:001463847900001
PM 40243895
DA 2025-06-11
ER

PT J
AU Kim, OY
   Song, J
AF Kim, Oh. Yoen
   Song, Juhyun
TI Important roles of linoleic acid and α-linolenic acid in regulating
   cognitive impairment and neuropsychiatric issues in metabolic-related
   dementia
SO LIFE SCIENCES
LA English
DT Article
DE Linoleic acid (LA); alpha-Linolenic acid (ALA); Dementia; Metabolic
   syndrome (MetS); Cognitive impairment
ID POLYUNSATURATED FATTY-ACIDS; HIPPOCAMPAL SYNAPTIC-TRANSMISSION;
   CARDIOVASCULAR RISK-FACTORS; BRAIN-BARRIER PERMEABILITY; TRIGLYCERIDE
   GLUCOSE INDEX; INDUCED INSULIN-RESISTANCE; ALZHEIMERS-DISEASE;
   DOCOSAHEXAENOIC ACID; DIETARY-INTAKE; SATURATED FAT
AB Metabolic syndrome (MetS), which is characterized by insulin resistance, high blood glucose, obesity, and dyslipidemia, is known to increase the risk of dementia accompanied by memory loss and depression. The direct pathways and specific mechanisms in the central nervous system (CNS) for addressing fatty acid imbalances in MetS have not yet been fully elucidated. Among polyunsaturated acids, linoleic acid (LA, n6-PUFA) and alpha-linolenic acid (ALA, n3-PUFA), which are two essential fatty acids that should be provided by food sources (e. g., vegetable oils and seeds), have been reported to regulate various cellular mechanisms including apoptosis, inflammatory responses, mitochondrial biogenesis, and insulin signaling. Furthermore, inadequate intake of LA and ALA is reported to be involved in neuropathology and neuropsychiatric diseases as well as imbalanced metabolic conditions. Herein, we review the roles of LA and ALA on metabolic-related dementia focusing on insulin resistance, dyslipidemia, synaptic plasticity, cognitive function, and neuropsychiatric issues. This review suggests that LA and ALA are important fatty acids for concurrent treatment of both MetS and neurological problems.
C1 [Kim, Oh. Yoen] Dong Univ, Dept Food Sci & Nutr, Pusan, South Korea.
   [Kim, Oh. Yoen] Dong A Univ, Grad Sch, Dept Hlth Sci, Pusan, South Korea.
   [Song, Juhyun] Chonnam Natl Univ, Dept Anat, Med Sch, Seoul, South Korea.
   [Song, Juhyun] Chonnam Natl Univ, Dept Anat, Med Sch, Hwasun 58128, Jeonranamdo, South Korea.
C3 Dong-Eui University; Dong A University; Chonnam National University;
   Chonnam National University
RP Song, J (corresponding author), Chonnam Natl Univ, Dept Anat, Med Sch, Seoul, South Korea.; Song, J (corresponding author), Chonnam Natl Univ, Dept Anat, Med Sch, Hwasun 58128, Jeonranamdo, South Korea.
EM oykim@dau.ac.kr; juhyunsong@chonnam.ac.kr
RI Kim, Oh/AAA-6492-2022
FU National Research Foundation of Korea (NRF) , South Korea
   [NRF-2022R1A2C1006125, NRF-2022R1A2C1010398]
FX This study was supported by grant NRF-2022R1A2C1006125 (Juhyun Song) and
   NRF-2022R1A2C1010398 (Oh Yoen Kim) from the National Research Foundation
   of Korea (NRF) , South Korea. The authors thank Biorender for making the
   figures.
CR Abbott NJ, 2010, NEUROBIOL DIS, V37, P13, DOI 10.1016/j.nbd.2009.07.030
   Saleh RA, 2022, J AM GERIATR SOC, V70, P3021, DOI 10.1111/jgs.17985
   Akaneya Y, 2007, GENE REGUL SYST BIO, V1, P83
   Ali W, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9030667
   Ali YM, 2012, PHARM BIOL, V50, P712, DOI 10.3109/13880209.2011.621714
   Allen NJ, 2017, NEURON, V96, P697, DOI 10.1016/j.neuron.2017.09.056
   Amick KA, 2022, FRONT AGING NEUROSCI, V14, DOI 10.3389/fnagi.2022.954090
   Anderson EJ, 2009, J CLIN INVEST, V119, P573, DOI 10.1172/JCI37048
   Anderson T, 2024, J NEUROCHEM, V168, P801, DOI 10.1111/jnc.15900
   Andreone BJ, 2017, NEURON, V94, P581, DOI 10.1016/j.neuron.2017.03.043
   Andrieu S, 2017, LANCET NEUROL, V16, P377, DOI 10.1016/S1474-4422(17)30040-6
   Appleton KM, 2010, AM J CLIN NUTR, V91, P757, DOI 10.3945/ajcn.2009.28313
   Armstrong NM, 2019, NEUROBIOL AGING, V75, P178, DOI 10.1016/j.neurobiolaging.2018.10.024
   Arnold SE, 2018, NAT REV NEUROL, V14, P168, DOI 10.1038/nrneurol.2017.185
   Azemi NA, 2023, METABOLITES, V13, DOI 10.3390/metabo13010053
   Bai F, 2016, ONCOTARGET, V7, P15315, DOI 10.18632/oncotarget.8100
   Baker EJ, 2016, PROG LIPID RES, V64, P30, DOI 10.1016/j.plipres.2016.07.002
   Barak Y, 2007, PPAR RES, V2007, DOI 10.1155/2007/12781
   Barisano G, 2022, J EXP MED, V219, DOI 10.1084/jem.20221137
   Barnes S, 2021, BRAIN BEHAV, V11, DOI 10.1002/brb3.2273
   Barón-Mendoza I, 2022, NUTR NEUROSCI, V25, P387, DOI 10.1080/1028415X.2020.1755793
   Barupal DK, 2019, ALZH DEMENT-DADM, V11, P619, DOI 10.1016/j.dadm.2019.07.002
   Bazinet RP, 2014, NAT REV NEUROSCI, V15, P771, DOI 10.1038/nrn3820
   Bazinet RP, 2009, BIOCHEM SOC T, V37, P1104, DOI 10.1042/BST0371104
   Bedse G, 2017, BIOL PSYCHIAT, V82, P488, DOI 10.1016/j.biopsych.2017.03.002
   Beeharry N, 2003, MUTAT RES-FUND MOL M, V530, P27, DOI 10.1016/S0027-5107(03)00134-9
   Belury MA, 2018, PROSTAG LEUKOTR ESS, V132, P30, DOI 10.1016/j.plefa.2018.03.001
   Belury MA, 2016, MOL NUTR FOOD RES, V60, P1206, DOI 10.1002/mnfr.201500744
   Belury MA, 2023, CURR OPIN CLIN NUTR, V26, P288, DOI 10.1097/MCO.0000000000000919
   Berger ME, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/tp.2017.190
   Bernal-Morales B, 2017, BIOMED RES INT, V2017, DOI 10.1155/2017/8798546
   Bernardo A, 2008, PPAR RES, V2008, DOI 10.1155/2008/864140
   Bialas AR, 2017, NATURE, V546, P539, DOI 10.1038/nature22821
   Bierhaus A, 2003, P NATL ACAD SCI USA, V100, P1920, DOI 10.1073/pnas.0438019100
   BITRAN D, 1995, J NEUROENDOCRINOL, V7, P171, DOI 10.1111/j.1365-2826.1995.tb00744.x
   Blanchard HC, 2015, PROSTAG LEUKOTR ESS, V96, P25, DOI 10.1016/j.plefa.2015.01.002
   Blasbalg TL, 2011, AM J CLIN NUTR, V93, P950, DOI 10.3945/ajcn.110.006643
   Blondeau N, 2002, NEUROSCIENCE, V109, P231, DOI 10.1016/S0306-4522(01)00473-0
   Blondeau N, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/519830
   Blondeau N, 2009, NEUROPSYCHOPHARMACOL, V34, P2548, DOI 10.1038/npp.2009.84
   Bocchio-Chiavetto L, 2010, WORLD J BIOL PSYCHIA, V11, P763, DOI 10.3109/15622971003611319
   Boneva NB, 2011, J PHARMACOL SCI, V116, P163, DOI 10.1254/jphs.10R34FM
   Bormann J, 2000, TRENDS PHARMACOL SCI, V21, P16, DOI 10.1016/S0165-6147(99)01413-3
   Boyce G, 2018, J BIOMED RES, V32, P164, DOI 10.7555/JBR.31.20160103
   Brenna JT, 2016, NUTR REV, V74, P329, DOI 10.1093/nutrit/nuw007
   Brunello CA, 2020, CELL MOL LIFE SCI, V77, P1721, DOI 10.1007/s00018-019-03349-1
   BULL AW, 1991, PROSTAGLANDINS, V41, P43, DOI 10.1016/0090-6980(91)90103-M
   Byelashov Oleksandr A, 2015, Lipid Technol, V27, P79, DOI 10.1002/lite.201500013
   Caldwell CC, 2015, NEUROTHERAPEUTICS, V12, P66, DOI 10.1007/s13311-014-0324-8
   Cao DH, 2009, J NEUROCHEM, V111, P510, DOI 10.1111/j.1471-4159.2009.06335.x
   Cardel M, 2015, J NUTR, V145, P2146, DOI 10.3945/jn.115.212365
   Carey AN, 2020, INFLAMMATION, V43, P241, DOI 10.1007/s10753-019-01113-y
   Carvalho C, 2012, DIABETES, V61, P1234, DOI 10.2337/db11-1186
   Cavedo E, 2018, ALZHEIMERS DEMENT, V14, P1204, DOI 10.1016/j.jalz.2018.05.014
   Chambenoit O, 2001, J BIOL CHEM, V276, P9955, DOI 10.1074/jbc.M010265200
   Chang L, 2003, J CLIN PSYCHIAT, V64, P7
   da Silva SMCS, 2023, BRIT J NUTR, V129, P2199, DOI 10.1017/S0007114522002835
   Chen CT, 2008, PROSTAG LEUKOTR ESS, V79, P85, DOI 10.1016/j.plefa.2008.09.003
   Chen John Xi, 2007, Expert Rev Neurother, V7, P1517, DOI 10.1586/14737175.7.11.1517
   Chen XR, 2018, J NEUROINFLAMM, V15, DOI [10.1186/s12974-018-1151-3, 10.1186/s12974-017-0917-3]
   Cheng Q, 2015, BIOCHEM PHARMACOL, V97, P439, DOI 10.1016/j.bcp.2015.07.015
   Chornenkyy Y, 2019, BRAIN PATHOL, V29, P3, DOI 10.1111/bpa.12655
   Chroni A, 2003, J BIOL CHEM, V278, P6719, DOI 10.1074/jbc.M205232200
   Chudobaa C, 2019, BIOL CHEM, V400, P991, DOI 10.1515/hsz-2018-0477
   Chung CP, 2018, NEUROIMAGE, V181, P627, DOI 10.1016/j.neuroimage.2018.07.049
   Citri A, 2008, NEUROPSYCHOPHARMACOL, V33, P18, DOI 10.1038/sj.npp.1301559
   Cole RM, 2020, CURR DEV NUTR, V4, DOI 10.1093/cdn/nzaa136
   Coleman SL, 2011, EUR J NUTR, V50, P323, DOI 10.1007/s00394-010-0140-9
   Cuciniello R, 2022, FREE RADICAL BIO MED, V191, P48, DOI 10.1016/j.freeradbiomed.2022.08.027
   Cunnane SC, 1999, PROSTAG LEUKOTR ESS, V60, P387, DOI 10.1016/S0952-3278(99)80018-0
   Cunnane SC, 2000, J LIPID RES, V41, P1808
   Cutuli D, 2017, CURR NEUROPHARMACOL, V15, P534, DOI 10.2174/1570159X14666160614091311
   Daley C, 2015, PUBLIC HEALTH NUTR, V18, P546, DOI 10.1017/S1368980014000561
   Das UN, 2005, MED SCI MONITOR, V11, pRA233
   Das Undurti N., 2006, Biotechnology Journal, V1, P420, DOI 10.1002/biot.200600012
   Davidson RJ, 2002, BIOL PSYCHIAT, V51, P68, DOI 10.1016/S0006-3223(01)01328-2
   de Bruijn RFAG, 2014, BMC MED, V12, DOI 10.1186/s12916-014-0130-5
   DeMar JC, 2006, BBA-MOL CELL BIOL L, V1761, P1050, DOI 10.1016/j.bbalip.2006.06.006
   Desale SE, 2021, MOL BIOMED, V2, DOI 10.1186/s43556-021-00028-1
   Desale SE, 2021, CELL ADHES MIGR, V15, P84, DOI 10.1080/19336918.2021.1898727
   Detka J, 2013, PHARMACOL REP, V65, P1591, DOI 10.1016/S1734-1140(13)71520-2
   Dhavale H S, 2013, J Assoc Physicians India, V61, P896
   Di Domenico F, 2017, FREE RADICAL BIO MED, V111, P253, DOI 10.1016/j.freeradbiomed.2016.10.490
   Di Miceli M, 2020, P NUTR SOC, V79, P388, DOI 10.1017/S0029665120000129
   Dorningues A, 2007, NEUROCHEM INT, V50, P872, DOI 10.1016/j.neuint.2007.03.001
   dos Santos MAB, 2014, REV BRAS PSIQUIATR, V36, P298, DOI 10.1590/1516-4446-2013-1230
   Dragano NRV, 2017, J NEUROINFLAMM, V14, DOI 10.1186/s12974-017-0869-7
   Drevets WC, 2002, EUR NEUROPSYCHOPHARM, V12, P527, DOI 10.1016/S0924-977X(02)00102-5
   Dubin MJ, 2016, J PSYCHIATR NEUROSCI, V41, pE37, DOI 10.1503/jpn.150223
   Duffy CM, 2017, MOL CELL NEUROSCI, V80, P52, DOI 10.1016/j.mcn.2017.02.004
   Dyall SC, 2017, LIPIDS, V52, P885, DOI 10.1007/s11745-017-4292-8
   Ebert D, 2003, J NEUROSCI, V23, P5928
   Echeverría F, 2016, PROSTAG LEUKOTR ESS, V114, P28, DOI 10.1016/j.plefa.2016.10.001
   Ekici F, 2014, TURK J MED SCI, V44, P535, DOI 10.3906/sag-1305-13
   Enna S J, 2013, Curr Protoc Pharmacol, V63, DOI 10.1002/0471141755.ph0107s63
   Fan R, 2020, J NUTR BIOCHEM, V76, DOI 10.1016/j.jnutbio.2019.108285
   Farvid MS, 2015, CIRCULATION, V132, pE23, DOI 10.1161/CIRCULATIONAHA.115.015526
   Farvid MS, 2014, CIRCULATION, V130, P1568, DOI 10.1161/CIRCULATIONAHA.114.010236
   Fedorova I, 2007, PROSTAG LEUKOTR ESS, V77, P269, DOI 10.1016/j.plefa.2007.10.013
   Fernandez ML, 2005, J NUTR, V135, P2075, DOI 10.1093/jn/135.9.2075
   FERNANDEZGUASTI A, 1995, EUR J PHARMACOL, V281, P113, DOI 10.1016/0014-2999(95)00311-8
   Ferrari CC, 2011, PARKINSONS DIS-US, V2011, DOI 10.4061/2011/436813
   Fogaça MV, 2019, FRONT CELL NEUROSCI, V13, DOI 10.3389/fncel.2019.00087
   Forouhi NG, 2016, PLOS MED, V13, DOI 10.1371/journal.pmed.1002094
   Rodríguez-Landa JF, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/121794
   Froyen E, 2020, NUTRIENTS, V12, DOI 10.3390/nu12082329
   Fuhrmann H, 2007, ANN NUTR METAB, V51, P155, DOI 10.1159/000103276
   Fujita S, 2001, BRIT J PHARMACOL, V132, P1417, DOI 10.1038/sj.bjp.0703970
   Fukui K, 2016, J BIOL CHEM, V291, P15910, DOI 10.1074/jbc.A115.664367
   Gabbouj S, 2019, FRONT NEUROSCI-SWITZ, V13, DOI 10.3389/fnins.2019.00629
   Galizzi G, 2022, BIOLOGY-BASEL, V11, DOI 10.3390/biology11060943
   Gambrill AC, 2011, P NATL ACAD SCI USA, V108, P5855, DOI 10.1073/pnas.1012676108
   Gao HQ, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0528-0
   Gao H, 2016, MOL NEUROBIOL, V53, P4772, DOI 10.1007/s12035-015-9393-x
   Géraldine M, 2010, NEUROCHEM INT, V56, P94, DOI 10.1016/j.neuint.2009.09.006
   Gibson RA, 2011, MATERN CHILD NUTR, V7, P17, DOI 10.1111/j.1740-8709.2011.00299.x
   Goddard AW, 2001, ARCH GEN PSYCHIAT, V58, P556, DOI 10.1001/archpsyc.58.6.556
   Grintal B, 2009, NEUROCHEM INT, V54, P535, DOI 10.1016/j.neuint.2009.02.018
   Grosso G, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0096905
   Grygiel-Górniak B, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-17
   Guasch-Ferré M, 2018, AM J CLIN NUTR, V108, P174, DOI 10.1093/ajcn/nqy091
   Guo ZY, 2017, SCI REP-UK, V7, DOI 10.1038/srep45971
   Gurung P, 2015, TRENDS MOL MED, V21, P193, DOI 10.1016/j.molmed.2014.11.008
   Gustafsson SB, 2013, ARCH TOXICOL, V87, P1939, DOI 10.1007/s00204-013-1051-3
   Gustavsson M, 2010, NUTR RES, V30, P279, DOI 10.1016/j.nutres.2010.04.005
   Hadjighassem M, 2015, NUTR J, V14, DOI 10.1186/s12937-015-0012-5
   Halcox JP, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0115270
   Hamano H, 1996, J NEUROPHYSIOL, V75, P1264, DOI 10.1152/jn.1996.75.3.1264
   Hanzel CE, 2014, NEUROBIOL AGING, V35, P2249, DOI 10.1016/j.neurobiolaging.2014.03.026
   Hartmann M, 2001, EMBO J, V20, P5887, DOI 10.1093/emboj/20.21.5887
   Hebert-Chatelain E, 2016, NATURE, V539, P555, DOI 10.1038/nature20127
   Heni M, 2015, NAT REV ENDOCRINOL, V11, P701, DOI 10.1038/nrendo.2015.173
   Hennebelle M, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-02914-7
   Heurteaux C, 2004, EMBO J, V23, P2684, DOI 10.1038/sj.emboj.7600234
   Heurteaux C, 2006, NEUROSCIENCE, V137, P241, DOI 10.1016/j.neuroscience.2005.08.083
   Heverin M, 2004, J LIPID RES, V45, P186, DOI 10.1194/jlr.M300320-JLR200
   HIBBELN JR, 1995, AM J CLIN NUTR, V62, P1
   Hong S, 2021, ALZHEIMERS RES THER, V13, DOI 10.1186/s13195-020-00758-4
   Horman T, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061847
   Hsu TM, 2014, FRONT AGING NEUROSCI, V6, DOI 10.3389/fnagi.2014.00088
   Hu L, 2022, IMMUN INFLAMM DIS, V10, DOI 10.1002/iid3.707
   Hunt WT, 2010, J NEUROCHEM, V115, P123, DOI 10.1111/j.1471-4159.2010.06908.x
   Hussein N, 2005, J LIPID RES, V46, P269, DOI 10.1194/jlr.M400225-JLR200
   IACONO JM, 1991, AM J CLIN NUTR, V53, P660, DOI 10.1093/ajcn/53.3.660
   Ikeguchi S, 2018, J PHARMACOL SCI, V138, P9, DOI 10.1016/j.jphs.2018.06.015
   Ikram M, 2019, MOL NEUROBIOL, V56, P6293, DOI 10.1007/s12035-019-1512-7
   Innis Sheila M, 2007, Curr Opin Endocrinol Diabetes Obes, V14, P359, DOI 10.1097/MED.0b013e3282be90b9
   Ioannou MS, 2019, CELL, V177, P1522, DOI 10.1016/j.cell.2019.04.001
   Jacka FN, 2013, BRIT J NUTR, V109, P2059, DOI 10.1017/S0007114512004102
   Jadoon A, 2012, J AFFECT DISORDERS, V136, P918, DOI 10.1016/j.jad.2011.09.007
   Jelenik T, 2010, DIABETES, V59, P2737, DOI 10.2337/db09-1716
   Jellinger Paul S, 2012, Endocr Pract, V18 Suppl 1, P1
   Jiang XY, 2008, J NEUROSCI, V28, P1118, DOI 10.1523/JNEUROSCI.2262-07.2008
   Jin P, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0705-9
   Joe EH, 2018, EXP NEUROBIOL, V27, P77, DOI 10.5607/en.2018.27.2.77
   Johnson GH, 2012, J ACAD NUTR DIET, V112, P1029, DOI 10.1016/j.jand.2012.03.029
   Jones DT, 2016, BRAIN, V139, P547, DOI 10.1093/brain/awv338
   Jones KL, 2013, BEHAV BRAIN RES, V238, P193, DOI 10.1016/j.bbr.2012.10.028
   Jump DB, 2012, J LIPID RES, V53, P2525, DOI 10.1194/jlr.R027904
   Vasques ACJ, 2011, DIABETES RES CLIN PR, V93, pE98, DOI 10.1016/j.diabres.2011.05.030
   Kadry H, 2020, FLUIDS BARRIERS CNS, V17, DOI 10.1186/s12987-020-00230-3
   Kapoor B, 2021, CURR NUTR REP, V10, P232, DOI 10.1007/s13668-021-00363-3
   Karthick C, 2019, NEUROL RES, V41, P139, DOI 10.1080/01616412.2018.1544745
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kaur N, 2014, J FOOD SCI TECH MYS, V51, P2289, DOI 10.1007/s13197-012-0677-0
   Kelly T, 2008, INT J OBESITY, V32, P1431, DOI 10.1038/ijo.2008.102
   Khairallah RJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034402
   Khan MS, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/7860650
   Kinney Jefferson W, 2018, Alzheimers Dement (N Y), V4, P575, DOI 10.1016/j.trci.2018.06.014
   Kleinridders A, 2015, P NATL ACAD SCI USA, V112, P3463, DOI 10.1073/pnas.1500877112
   Kleinridders A, 2014, DIABETES, V63, P2232, DOI 10.2337/db14-0568
   Kleinridders A, 2013, J CLIN INVEST, V123, P4667, DOI 10.1172/JCI67615
   Kojro E, 2001, P NATL ACAD SCI USA, V98, P5815, DOI 10.1073/pnas.081612998
   Kosukegawa S, 2023, J ORAL SCI, V65, P77, DOI 10.2334/josnusd.22-0438
   Koyama A, 2013, J GERONTOL A-BIOL, V68, P433, DOI 10.1093/gerona/gls187
   Kra G, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-32433-7
   Kris-Etherton PM, 2000, AM J CLIN NUTR, V71, p179S, DOI 10.1093/ajcn/71.1.179S
   Krstic D, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-151
   Kummer MP, 2008, PPAR RES, V2008, DOI 10.1155/2008/403896
   Kuo YT, 2010, NEUROIMAGE, V50, P1384, DOI 10.1016/j.neuroimage.2010.01.057
   Lamkanfi M, 2014, CELL, V157, P1013, DOI 10.1016/j.cell.2014.04.007
   LANEUVILLE O, 1995, J BIOL CHEM, V270, P19330, DOI 10.1074/jbc.270.33.19330
   Lanza IR, 2013, AM J PHYSIOL-ENDOC M, V304, pE1391, DOI 10.1152/ajpendo.00584.2012
   Larrieu T, 2014, TRANSL PSYCHIAT, V4, DOI 10.1038/tp.2014.77
   Laudisi F, 2013, J IMMUNOL, V191, P1006, DOI 10.4049/jimmunol.1300489
   Lauritzen I, 2000, EMBO J, V19, P1784, DOI 10.1093/emboj/19.8.1784
   Leaf A, 2002, PROSTAG LEUKOTR ESS, V67, P113, DOI 10.1054/plef.2002.0407
   Lee HM, 2013, DIABETES, V62, P194, DOI 10.2337/db12-0420
   Leikin-Frenkel A, 2022, NUTRIENTS, V14, DOI 10.3390/nu14235091
   Leung JWC, 2003, CNS NEUROL DISORD-DR, V2, P363, DOI 10.2174/1568007033482715
   Li D, 2020, NUTRITION, V71, DOI 10.1016/j.nut.2019.110602
   Liao WX, 2017, ONCOTARGET, V8, P76214, DOI 10.18632/oncotarget.19185
   Lin HY, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-89494-9
   Litwiniuk A, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/8908901
   Liu CC, 2013, NAT REV NEUROL, V9, P106, DOI 10.1038/nrneurol.2012.263
   Long JM, 2019, CELL, V179, P312, DOI 10.1016/j.cell.2019.09.001
   Lopez-Garcia E, 2004, J NUTR, V134, P1806, DOI 10.1093/jn/134.7.1806
   López-Vicente M, 2019, J PEDIATR-US, V209, P204, DOI 10.1016/j.jpeds.2019.02.022
   Lowry JR, 2020, MOL CELL NEUROSCI, V109, DOI 10.1016/j.mcn.2020.103569
   Lucas M, 2011, AM J CLIN NUTR, V93, P1337, DOI 10.3945/ajcn.111.011817
   Luo RC, 2020, AUTOPHAGY, V16, P52, DOI 10.1080/15548627.2019.1596488
   Lykhmus O, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0122706
   Ma MT, 2010, NEUROSCI LETT, V476, P36, DOI 10.1016/j.neulet.2010.03.078
   Ma NN, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11010055
   Magnan C, 2015, MOL CELL ENDOCRINOL, V418, P3, DOI 10.1016/j.mce.2015.09.019
   Mamounis KJ, 2017, J NUTR BIOCHEM, V40, P122, DOI 10.1016/j.jnutbio.2016.10.016
   Manosalva C, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0119715
   Mariamenatu AH, 2021, J LIPIDS, V2021, DOI 10.1155/2021/8848161
   Massaro M, 2006, P NATL ACAD SCI USA, V103, P15184, DOI 10.1073/pnas.0510086103
   Matravadia S, 2014, AM J PHYSIOL-ENDOC M, V307, pE102, DOI 10.1152/ajpendo.00032.2014
   Mazucanti CH, 2019, JCI INSIGHT, V4, DOI 10.1172/jci.insight.131682
   Mazzocchi-Jones D, 2015, BRAIN RES BULL, V111, P69, DOI 10.1016/j.brainresbull.2014.12.010
   McCann RF, 2017, BIOL PSYCHIAT, V82, pE11, DOI 10.1016/j.biopsych.2017.05.020
   McElroy SL, 2004, J CLIN PSYCHIAT, V65, P634
   McNamara RK, 2006, PROSTAG LEUKOTR ESS, V75, P329, DOI 10.1016/j.plefa.2006.07.010
   Mensink RP, 2003, AM J CLIN NUTR, V77, P1146, DOI 10.1093/ajcn/77.5.1146
   Meyer BJ, 2003, LIPIDS, V38, P391, DOI 10.1007/s11745-003-1074-0
   Michailidis M, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23052687
   Michalik L, 2006, PHARMACOL REV, V58, P726, DOI 10.1124/pr.58.4.5
   Mirnikjoo B, 2001, J BIOL CHEM, V276, P10888, DOI 10.1074/jbc.M008150200
   Misra A, 2004, J Assoc Physicians India, V52, P137
   Mohammadi S, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.841282
   Monaco A, 2018, J LIPID RES, V59, P48, DOI 10.1194/jlr.M079400
   Montagne A, 2020, NATURE, V581, P70, DOI 10.1038/s41586-020-2247-3
   Mooradian AD, 2009, NAT CLIN PRACT ENDOC, V5, P150, DOI 10.1038/ncpendmet1066
   Moret Chantal, 2011, Neuropsychiatr Dis Treat, V7, P9, DOI 10.2147/NDT.S19619
   Mosconi L, 2011, Q J NUCL MED MOL IM, V55, P250
   Mukerjee S, 2021, MEMBRANES-BASEL, V11, DOI 10.3390/membranes11070479
   Santos FRM, 2013, DIABETOL METAB SYNDR, V5, DOI 10.1186/1758-5996-5-55
   Muniyappa R, 2013, MOL CELL ENDOCRINOL, V378, P59, DOI 10.1016/j.mce.2012.05.017
   Murru E, 2021, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.587140
   Nabekura J, 1998, J BIOL CHEM, V273, P11056, DOI 10.1074/jbc.273.18.11056
   Nagano M, 2019, COMMUN BIOL, V2, DOI 10.1038/s42003-019-0670-5
   Nakagawa K, 2015, J NUTR SCI VITAMINOL, V61, pS78, DOI 10.3177/jnsv.61.S78
   Nakamura S, 2009, J BIOL CHEM, V284, P14809, DOI 10.1074/jbc.M901488200
   Nallathamby N, 2016, NAT PROD COMMUN, V11, P1485
   Nasehi M, 2018, BEHAV BRAIN RES, V351, P152, DOI 10.1016/j.bbr.2018.06.002
   Naveed S, 2020, PUBLIC HEALTH NUTR, V23, P1657, DOI 10.1017/S1368980019003860
   Nemeroff Charles B, 2003, Psychopharmacol Bull, V37, P133
   Nemeth M, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0140485
   Nemoto T, 2014, CELL SIGNAL, V26, P253, DOI 10.1016/j.cellsig.2013.11.017
   Neth BJ, 2017, FRONT AGING NEUROSCI, V9, DOI 10.3389/fnagi.2017.00345
   Nuss P, 2015, NEUROPSYCH DIS TREAT, V11, P165, DOI 10.2147/NDT.S58841
   Nutt DJ, 2002, INT J NEUROPSYCHOPH, V5, P315, DOI 10.1017/S1461145702003048
   Obinata H, 2005, J BIOL CHEM, V280, P40676, DOI 10.1074/jbc.M507787200
   Oellingrath IM, 2014, PUBLIC HEALTH NUTR, V17, P2554, DOI 10.1017/S1368980013002747
   Offermanns S, 2014, ANNU REV PHARMACOL, V54, P407, DOI 10.1146/annurev-pharmtox-011613-135945
   Ohsawa M, 2008, ATHEROSCLEROSIS, V201, P184, DOI 10.1016/j.atherosclerosis.2008.01.008
   Ohue-Kitano R, 2018, FASEB J, V32, P304, DOI 10.1096/fj.201700273R
   Orr SK, 2013, J NEUROCHEM, V127, P378, DOI 10.1111/jnc.12392
   PACIFICI EHK, 1994, FREE RADICAL BIO MED, V17, P285, DOI 10.1016/0891-5849(94)90015-9
   Palomba L, 2009, GLIA, V57, P1672, DOI 10.1002/glia.20879
   Pan A, 2012, AM J CLIN NUTR, V96, P1262, DOI 10.3945/ajcn.112.044040
   Panov A, 2014, BIOMED RES INT-UK, V2014, DOI 10.1155/2014/472459
   Papassotiropoulos A, 2002, J PSYCHIAT RES, V36, P27, DOI 10.1016/S0022-3956(01)00050-4
   Pauls SD, 2018, J NUTR BIOCHEM, V57, P121, DOI 10.1016/j.jnutbio.2018.03.020
   Perica MM, 2011, NUTR CLIN PRACT, V26, P409, DOI 10.1177/0884533611411306
   Petersen J.D., 2017, Int. J. Alzheimers Dis., V2017
   Petersen MC, 2018, PHYSIOL REV, V98, P2133, DOI 10.1152/physrev.00063.2017
   Pocivavsek A, 2009, J NEUROIMMUNOL, V214, P25, DOI 10.1016/j.jneuroim.2009.06.010
   Poletto AC, 2015, MOL CELL ENDOCRINOL, V401, P65, DOI 10.1016/j.mce.2014.12.001
   Qiao H, 2016, NEURAL PLAST, V2016, DOI 10.1155/2016/8056370
   Raison CL, 2006, TRENDS IMMUNOL, V27, P24, DOI 10.1016/j.it.2005.11.006
   Rammes G, 2018, NEUROPHARMACOLOGY, V140, P184, DOI 10.1016/j.neuropharm.2018.07.021
   Ramsden CE, 2017, SCI SIGNAL, V10, DOI 10.1126/scisignal.aal5241
   Ramsden CE, 2016, MOL PAIN, V12, DOI 10.1177/1744806916636386
   Ramsden CE, 2016, BMJ-BRIT MED J, V353, DOI 10.1136/bmj.i1246
   Ramsden CE, 2013, PAIN, V154, P2441, DOI 10.1016/j.pain.2013.07.028
   Ramsden CE, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.e8707
   Ramsden CE, 2012, PROSTAG LEUKOTR ESS, V87, P135, DOI 10.1016/j.plefa.2012.08.004
   Rand D, 2021, NEURAL REGEN RES, V16, P2390, DOI 10.4103/1673-5374.313031
   Rao J, 2015, NEURODEGENER DIS, V15, P38, DOI 10.1159/000369214
   Rasmusson AM, 2002, NEUROPSYCHOPHARMACOL, V27, P133, DOI 10.1016/S0893-133X(02)00286-5
   Reaven GM, 2005, ANNU REV NUTR, V25, P391, DOI 10.1146/annurev.nutr.24.012003.132155
   Refolo LM, 2001, NEUROBIOL DIS, V8, P890, DOI 10.1006/nbdi.2001.0422
   Ressler KJ, 2000, DEPRESS ANXIETY, V12, P2, DOI 10.1002/1520-6394(2000)12:1+<2::AID-DA2>3.3.CO;2-W
   Rey C, 2018, PROSTAG LEUKOTR ESS, V133, P1, DOI 10.1016/j.plefa.2018.04.003
   Rhea EM, 2019, FRONT NEUROSCI-SWITZ, V13, DOI 10.3389/fnins.2019.00521
   Risérus U, 2009, PROG LIPID RES, V48, P44, DOI 10.1016/j.plipres.2008.10.002
   Rosqvist F, 2014, DIABETES, V63, P2356, DOI 10.2337/db13-1622
   Ruan H, 2016, J MOL CELL BIOL, V8, P101, DOI 10.1093/jmcb/mjw014
   Rukadikar C, 2023, CUREUS J MED SCIENCE, V15, DOI 10.7759/cureus.42926
   Ryan JP, 2012, PSYCHOSOM MED, V74, P476, DOI 10.1097/PSY.0b013e31824d0865
   Saba F, 2019, NUTR NEUROSCI, V22, P207, DOI 10.1080/1028415X.2017.1367130
   Sala-Vila A, 2022, ADV NUTR, V13, P1584, DOI 10.1093/advances/nmac016
   Salem N, 2001, J MOL NEUROSCI, V16, P299, DOI 10.1385/JMN:16:2-3:299
   Salgado-Mendialdúa V, 2018, BIOCHEM PHARMACOL, V157, P159, DOI 10.1016/j.bcp.2018.08.026
   Sambra V, 2021, NUTRIENTS, V13, DOI 10.3390/nu13030986
   Sanders TAB, 1997, ARTERIOSCL THROM VAS, V17, P3449, DOI 10.1161/01.ATV.17.12.3449
   Sang N, 2005, J NEUROSCI, V25, P9858, DOI 10.1523/JNEUROSCI.2392-05.2005
   Schell M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051518
   Schneider C, 2004, CHEM RES TOXICOL, V17, P937, DOI 10.1021/tx049913n
   Schuster S, 2018, J LIPID RES, V59, P1597, DOI 10.1194/jlr.M083741
   Serrano-Pozo A, 2011, CSH PERSPECT MED, V1, DOI 10.1101/cshperspect.a006189
   Sheikh AM, 2009, GLIA, V57, P898, DOI 10.1002/glia.20815
   Shinjyo N, 2013, J NEUROSCI RES, V91, P943, DOI 10.1002/jnr.23231
   Shiri M, 2017, CAN J PHYSIOL PHARM, V95, P382, DOI 10.1139/cjpp-2016-0274
   Simopoulos AP, 2002, BIOMED PHARMACOTHER, V56, P365, DOI 10.1016/S0753-3322(02)00253-6
   Simopoulos AP, 2008, EXP BIOL MED, V233, P674, DOI 10.3181/0711-MR-311
   Simopoulos AP, 2011, WORLD REV NUTR DIET, V102, P10, DOI 10.1159/000327785
   Simopoulos AP, 2011, MOL NEUROBIOL, V44, P203, DOI 10.1007/s12035-010-8162-0
   Sinha S, 2004, J BIOL CHEM, V279, P41294, DOI 10.1074/jbc.M406514200
   Siracusa R, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.01114
   Skelly DT, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0069123
   Soares JKB, 2013, NEUROSCI LETT, V552, P25, DOI 10.1016/j.neulet.2013.07.028
   Solomon A, 2009, DEMENT GERIATR COGN, V28, P75, DOI 10.1159/000231980
   Sontrop J, 2008, PAEDIATR PERINAT EP, V22, P389, DOI 10.1111/j.1365-3016.2008.00941.x
   Souza GFP, 2016, SCI REP-UK, V6, DOI 10.1038/srep29290
   Stroupe C, 2018, FRONT CELL DEV BIOL, V6, DOI 10.3389/fcell.2018.00129
   Stukas S, 2014, CELL METAB, V19, P574, DOI 10.1016/j.cmet.2014.01.003
   Su HQ, 2021, J EXTRACELL VESICLES, V10, DOI 10.1002/jev2.12089
   Sublette ME, 2009, PROSTAG LEUKOTR ESS, V80, P57, DOI 10.1016/j.plefa.2008.11.004
   Summers LKM, 2002, DIABETOLOGIA, V45, P369, DOI 10.1007/s00125-001-0768-3
   Suridjan I, 2015, MOL PSYCHIATR, V20, P1579, DOI 10.1038/mp.2015.1
   Swardfager W, 2010, BIOL PSYCHIAT, V68, P930, DOI 10.1016/j.biopsych.2010.06.012
   Sweeney MD, 2018, NAT REV NEUROL, V14, P133, DOI 10.1038/nrneurol.2017.188
   Swerdlow RH, 2004, MED HYPOTHESES, V63, P8, DOI 10.1016/j.mehy.2003.12.045
   Tackenberg C, 2013, CELL DEATH DIS, V4, DOI 10.1038/cddis.2013.129
   Taha AY, 2020, NPJ SCI FOOD, V4, DOI 10.1038/s41538-019-0061-9
   Taha AY, 2018, PROSTAG LEUKOTR ESS, V138, P71, DOI 10.1016/j.plefa.2016.05.004
   Talbot K, 2012, J CLIN INVEST, V122, P1316, DOI 10.1172/JCI59903
   Teng ZJ, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.970122
   Thambisetty M, 2012, J CEREBR BLOOD F MET, V32, P676, DOI 10.1038/jcbfm.2011.171
   Theparambil SM, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-18756-3
   Tofighi N, 2021, NEUROTOXICOLOGY, V85, P245, DOI 10.1016/j.neuro.2021.06.002
   Toledo JB, 2013, BRAIN, V136, P2697, DOI 10.1093/brain/awt188
   Tosi F, 2014, ADV EXP MED BIOL, V824, P61, DOI 10.1007/978-3-319-07320-0_7
   Tracey TJ, 2018, FRONT MOL NEUROSCI, V11, DOI 10.3389/fnmol.2018.00010
   Trousson A, 2009, J NEUROCHEM, V109, P945, DOI 10.1111/j.1471-4159.2009.06009.x
   Tu TH, 2019, BIOCHEM BIOPH RES CO, V513, P201, DOI 10.1016/j.bbrc.2019.03.047
   Tu WC, 2010, PROSTAG LEUKOTR ESS, V83, P61, DOI 10.1016/j.plefa.2010.04.001
   Turovsky EA, 2021, Int J. Mol. Sci., V22
   Tynkkynen J, 2018, ALZHEIMERS DEMENT, V14, P723, DOI 10.1016/j.jalz.2018.01.003
   Valdearcos M, 2018, CELL METAB, V27, P1356, DOI 10.1016/j.cmet.2018.04.019
   Valdearcos M, 2014, CELL REP, V9, P2124, DOI 10.1016/j.celrep.2014.11.018
   Valenzuela R, 2024, BIOFACTORS, V50, P89, DOI 10.1002/biof.1992
   Valverde O, 2012, NEUROSCIENCE, V204, P193, DOI 10.1016/j.neuroscience.2011.09.031
   van Himbergen TM, 2012, ARCH NEUROL-CHICAGO, V69, P594, DOI 10.1001/archneurol.2011.670
   Vandal M, 2014, J NEUROCHEM, V129, P516, DOI 10.1111/jnc.12640
   Venna VR, 2009, PSYCHONEUROENDOCRINO, V34, P199, DOI 10.1016/j.psyneuen.2008.08.025
   Vicario CM, 2017, NEUROSCI BIOBEHAV R, V80, P185, DOI 10.1016/j.neubiorev.2017.05.008
   Videla LA, 2022, PROSTAG LEUKOTR ESS, V181, DOI 10.1016/j.plefa.2022.102441
   Voss S, 1997, Z ERNAHRUNGSWISS, V36, P229, DOI 10.1007/BF01623369
   Wang DD, 2016, JAMA INTERN MED, V176, P1134, DOI 10.1001/jamainternmed.2016.2417
   Wang H, 2016, MILITARY MED RES, V3, DOI 10.1186/s40779-016-0095-0
   Wang Q, 2022, J TRANSL MED, V20, DOI 10.1186/s12967-022-03786-w
   Wang S, 2009, BRIT J NUTR, V102, P497, DOI 10.1017/S0007114509231758
   Wang TD, 2020, BEHAV BRAIN RES, V384, DOI 10.1016/j.bbr.2020.112545
   Warensjö E, 2006, AM J CLIN NUTR, V84, P442
   Warner DR, 2017, AM J PATHOL, V187, P2232, DOI 10.1016/j.ajpath.2017.06.008
   Weyman-Vela Y, 2022, ENDOCR RES, V47, P89, DOI 10.1080/07435800.2022.2061508
   Whelan J, 2013, ADV NUTR, V4, P311, DOI 10.3945/an.113.003772
   Whitaker BN, 2018, J PEDIATR HEALTH CAR, V32, pE37, DOI 10.1016/j.pedhc.2017.09.008
   Willette AA, 2015, ALZHEIMERS DEMENT, V11, P504, DOI 10.1016/j.jalz.2014.03.011
   Willis LM, 2010, INFLAMMATION, V33, P325, DOI 10.1007/s10753-010-9189-0
   Wong MW, 2017, ALZHEIMERS DEMENT, V13, P810, DOI 10.1016/j.jalz.2017.01.008
   Wu JHY, 2017, LANCET DIABETES ENDO, V5, P965, DOI [10.1016/s2213-8587(17)30307-8, 10.1016/S2213-8587(17)30307-8]
   Wu JHY, 2012, BRIT J NUTR, V107, pS214, DOI 10.1017/S0007114512001602
   Wynn TA, 2013, NATURE, V496, P445, DOI 10.1038/nature12034
   Xu HL, 2015, MOL CELL BIOL, V35, P1055, DOI 10.1128/MCB.01122-14
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Xu JH, 2007, J IMMUNOL, V178, P1904, DOI 10.4049/jimmunol.178.3.1904
   Yaguchi T, 2010, NEUROCHEM RES, V35, P712, DOI 10.1007/s11064-010-0124-4
   Yamada D, 2014, NEUROPSYCHOPHARMACOL, V39, P1852, DOI 10.1038/npp.2014.32
   Yamamoto S, 2005, NEUROSCIENCE, V130, P207, DOI 10.1016/j.neuroscience.2004.09.016
   Yamashita A, 2017, J AFFECT DISORDERS, V218, P306, DOI 10.1016/j.jad.2017.04.062
   Yang Y, 2014, ACTA PHARMACOL SIN, V35, P1285, DOI 10.1038/aps.2014.64
   Yau SY, 2022, BEHAV BRAIN RES, V416, DOI 10.1016/j.bbr.2021.113538
   Yin HY, 2012, FREE RADICAL RES, V46, P959, DOI 10.3109/10715762.2012.676642
   Yoneyama S, 2007, J EPIDEMIOL, V17, P86, DOI 10.2188/jea.17.86
   Young VM, 1998, METABOLISM, V47, P566, DOI 10.1016/S0026-0495(98)90241-4
   Yuan MS, 2001, SCIENCE, V293, P1673, DOI 10.1126/science.1061620
   Yuan XY, 2023, BRIT J NUTR, V129, P737, DOI 10.1017/S0007114522001325
   Zarrouk A, 2018, CURR ALZHEIMER RES, V15, P303, DOI 10.2174/1567205014666170505101426
   Zhang H, 2015, DIABETES, V64, P1025, DOI 10.2337/db14-1000
   Zhang RZ, 2013, J NEUROIMMUNOL, V256, P38, DOI 10.1016/j.jneuroim.2013.01.002
   Zhang T, 2016, J ALZHEIMERS DIS, V50, P455, DOI 10.3233/JAD-150810
   Zhang Y, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-122
   Zhang Y, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-81
   Zhao GX, 2007, AM J CLIN NUTR, V85, P385, DOI 10.1093/ajcn/85.2.385
   Zhao GX, 2004, J NUTR, V134, P2991, DOI 10.1093/jn/134.11.2991
   Zhao QF, 2016, J AFFECT DISORDERS, V190, P264, DOI 10.1016/j.jad.2015.09.069
   Zhao YY, 2022, NAT COMMUN, V13, DOI 10.1038/s41467-022-28769-9
   Zhou JW, 2022, BRIT J NUTR, V127, P1386, DOI 10.1017/S0007114521002300
   Zhu Y, 2019, J ALZHEIMERS DIS, V70, P843, DOI 10.3233/JAD-190254
NR 385
TC 30
Z9 30
U1 8
U2 29
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JAN 15
PY 2024
VL 337
AR 122356
DI 10.1016/j.lfs.2023.122356
EA DEC 2023
PG 17
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA EZ2A2
UT WOS:001142681000001
PM 38123015
OA hybrid
DA 2025-06-11
ER

PT J
AU Eriksson, BE
   Tyni-Lennè, R
   Svedenhag, J
   Hallin, R
   Jensen-Urstad, K
   Jensen-Urstad, M
   Bergman, K
   Sylvén, C
AF Eriksson, BE
   Tyni-Lennè, R
   Svedenhag, J
   Hallin, R
   Jensen-Urstad, K
   Jensen-Urstad, M
   Bergman, K
   Sylvén, C
TI Physical training in Syndrome X -: Physical training counteracts
   deconditioning and pain in Syndrome X
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
ID NORMAL CORONARY ARTERIOGRAMS; CHEST PAIN; ANGINA-PECTORIS;
   ATHEROSCLEROSIS; ANGIOGRAMS; ADENOSINE; ARTERIES; STRESS
AB OBJECTIVES The aim of this study was to evaluate the effects of exercise training and body-awareness training in female patients with Syndrome X.
   BACKGROUND Patients with Syndrome X, defined as effort-induced angina pectoris, a positive exercise test and a normal coronary angiogram, suffer from a chronic pain disorder. We hypothesized that this disorder results in physical deconditioning with decreased exertional pain threshold.
   METHODS Twenty-six patients were randomly assigned to two training groups (A, B) and a control group (C). Group A (n = 8) started, after baseline measurements, with eight weeks of body-awareness training followed by eight weeks of exercise training on a bicycle ergometer three times a week for 30 min at an intensity of 50% of peak work rate. Group B (n = 8) performed only eight weeks of exercise training. Group C (n = 10) acted as controls without any intervention whatsoever. The effects on exercise performance, hormonal secretion, vascular function, adenosine sensitivity and quality of life were evaluated.
   RESULTS Body-awareness training did not change the pain response. The two training groups did not differ in effects of exercise training. Exercise capacity before training was below the gender- and age-matched reference range and improved by 34% with training to a level not different from the reference range. Onset of pain was delayed by 100% from 3 +/- 2 to 6 +/- 3 min (p ( < 0.05) while maximum pain did not change. Thus the: pain-response-to-exercise curve was shifted to the right. Syndrome X patients showed a hypersensitivity to loll-dose adenosine infusion compared to healthy age- and gender-matched controls (p < 0.0001) that did not change with exercise training. Endothelium-dependent blood flow increase was at baseline within reference range and tended to increase (p < 0.06) following training. In Group A the concentration of cortisol in urine decreased by 53% after body-awareness training (p < 0.05), and this change from baseline remained after physical exercise training (p < 0.05). A similar decrease occurred with only exercise training (Group B).
   CONCLUSIONS Physical deconditioning with lower exertional threshold for pain is a prominent feature in Syndrome X. Physical training in Syndrome X results in an increased exercise capacity with lesser anginal pain. We suggest physical training as an effective treatment in Syndrome X. (C) 2000 by the American College of Cardiology.
C1 Huddinge Univ Hosp, Dept Cardiol, S-14189 Stockholm, Sweden.
   Huddinge Univ Hosp, Dept Physiotherapy, S-14189 Stockholm, Sweden.
   Huddinge Univ Hosp, Dept Clin Physiol, S-14189 Stockholm, Sweden.
   Huddinge Univ Hosp, Dept Neurophysiol, S-14189 Stockholm, Sweden.
   South Hosp, Dept Clin Physiol, Stockholm, Sweden.
C3 Karolinska Institutet; Karolinska Institutet; Karolinska Institutet;
   Karolinska Institutet
RP Eriksson, BE (corresponding author), Huddinge Univ Hosp, Dept Cardiol, S-14189 Stockholm, Sweden.
CR ASTROM H, 1976, BRIT HEART J, V3, P289
   CANNON RO, 1990, J AM COLL CARDIOL, V16, P1359, DOI 10.1016/0735-1097(90)90377-2
   CANNON RO, 1992, CIRCULATION, V85, P883, DOI 10.1161/01.CIR.85.3.883
   CANNON RO, 1994, NEW ENGL J MED, V330, P1411, DOI 10.1056/NEJM199405193302003
   CELERMAJER DS, 1992, LANCET, V340, P1111, DOI 10.1016/0140-6736(92)93147-F
   CHAUHAN A, 1994, J AM COLL CARDIOL, V24, P329, DOI 10.1016/0735-1097(94)90284-4
   Clarkson P, 1999, J AM COLL CARDIOL, V33, P1379, DOI 10.1016/S0735-1097(99)00036-4
   CLINE MA, 1989, BRAIN, V112, P621, DOI 10.1093/brain/112.3.621
   DALLMAN MF, 1993, TRENDS ENDOCRIN MET, V4, P62, DOI 10.1016/S1043-2760(05)80017-7
   EGASHIRA K, 1993, NEW ENGL J MED, V328, P1659, DOI 10.1056/NEJM199306103282302
   ELIASSON T, 1993, CORONARY ARTERY DIS, V4, P819
   Eriksson BE, 1999, AM J CARDIOL, V84, P176, DOI 10.1016/S0002-9149(99)00230-1
   ERIKSSON BE, 1995, AM J CARDIOL, V75, P2241
   EWART CK, 1983, AM J CARDIOL, V51, P2
   Frankenhaeuser M., 1983, BIOBEHAVIORAL BASES, P91
   JensenUrstad KJ, 1996, DIABETES, V45, P1253, DOI 10.2337/diabetes.45.9.1253
   KEMP HG, 1973, AM J CARDIOL, V32, P375, DOI 10.1016/S0002-9149(73)80150-X
   KUCHEL O, 1991, NEUROENDOCRINOLOGY S
   LAGERQVIST B, 1992, BRIT HEART J, V68, P282
   LICHTLEN PR, 1995, J AM COLL CARDIOL, V25, P1013, DOI 10.1016/0735-1097(94)00519-V
   NORDENFELT I, 1985, CLIN PHYSIOL, V5, P161, DOI 10.1111/j.1475-097X.1985.tb00592.x
   Panza JA, 1997, J AM COLL CARDIOL, V29, P293, DOI 10.1016/S0735-1097(96)00481-0
   PROUDFIT WL, 1980, CIRCULATION, V62, P712, DOI 10.1161/01.CIR.62.4.712
   ROSANO GMC, 1990, CLIN SCI, V8, P9
   SAX FL, 1987, NEW ENGL J MED, V317, P1366, DOI 10.1056/NEJM198711263172202
   Sylven C, 1996, NEUROREPORT, V7, P1521, DOI 10.1097/00001756-199606170-00017
   Wilmore J., 1994, Human Kinetics
NR 27
TC 72
Z9 77
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 USA
SN 0735-1097
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD NOV 1
PY 2000
VL 36
IS 5
BP 1619
EP 1625
DI 10.1016/S0735-1097(00)00931-1
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 371GY
UT WOS:000165171500026
PM 11079667
DA 2025-06-11
ER

PT J
AU Zhu, LY
   Ruan, XY
   Wang, JQ
   Yan, YX
   Tang, CY
   Xu, YW
AF Zhu, Linying
   Ruan, Xiaoyi
   Wang, Jianqi
   Yan, Yongxing
   Tang, Chunyuan
   Xu, Yuanwen
TI Higher oxidative balance score is linearly associated with reduced
   prevalence of chronic kidney disease in individuals with metabolic
   syndrome: evidence from NHANES 1999-2018
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE oxidative balance score; oxidative stress; metabolic syndrome; chronic
   kidney disease; NHANES
ID RISK; DEFINITION; MORTALITY; SMOKING
AB Background: Oxidative stress is a key contributor to the development of chronic kidney disease (CKD) in individuals with metabolic syndrome (MetS). The oxidative balance score (OBS) is an emerging composite assessment tool for dietary and lifestyle oxidative balance. We aimed to explore the association of OBS with CKD prevalence in MetS in this national cross-sectional analysis. Methods: This was a national cross-sectional analysis. Eligible MetS participants >= 20 years of age from NHANES 1999-2018 were included. OBS was assessed according to previous well-validated methods and consisted of 16 dietary components and 4 lifestyle components. MetS was diagnosed by NCEP-ATP III criteria, while CKD was diagnosed by KDIGO 2021 Clinical Practice Guideline. Multivariate logistic regression models were used to explore the association of OBS with CKD in MetS in this national cross-sectional analysis. Results: A total of 8,095 MetS participants were included, with a CKD prevalence of 24.8%. In fully adjusted models, each score increases in OBS, dietary OBS, and lifestyle OBS was associated with a 2, 1.7, and 7.3% reduction in the prevalence of CKD, respectively. Higher OBS, dietary OBS, and lifestyle OBS were all associated with significantly lower odds of CKD (p for trend all <0.05). Restricted cubic spline analysis showed that these associations all exhibited inverse dose-response. Interaction analyses indicated that cardiovascular disease (CVD) status significantly influenced the impact of OBS and dietary OBS, and these associations were only present in CVD-free subjects. Defining MetS using the IDF criteria did not significantly change the results. Conclusion: OBS was inversely associated with the prevalence of CKD in MetS, especially in CVD-free settings. These findings emphasize that adherence to an antioxidant diet and lifestyle contributes to the early prevention of CKD in the MetS population and necessitates attention to CVD interactions. Future prospective cohort studies are needed to confirm these results.
C1 [Zhu, Linying; Yan, Yongxing] Guangdong Med Univ, Sch Obstet & Pediat, Zhanjiang, Guangdong, Peoples R China.
   [Ruan, Xiaoyi; Wang, Jianqi] Guangdong Med Univ, Clin Coll 1, Zhanjiang, Guangdong, Peoples R China.
   [Tang, Chunyuan; Xu, Yuanwen] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou, Guangdong, Peoples R China.
C3 Guangdong Medical University; Guangdong Medical University; Sun Yat Sen
   University
RP Tang, CY; Xu, YW (corresponding author), Sun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou, Guangdong, Peoples R China.
EM tchuny@mail.sysu.edu.cn; xuyw@mail.sysu.edu.cn
RI Wang, Jianqi/M-6380-2013
CR Åberg F, 2023, J HEPATOL, V78, P191, DOI 10.1016/j.jhep.2022.08.030
   Abraham NG, 2007, ANN NY ACAD SCI, V1113, P256, DOI 10.1196/annals.1391.015
   Adair KE, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041007
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Asghari G, 2018, EUR J NUTR, V57, P2377, DOI 10.1007/s00394-017-1511-2
   Caliri AW, 2021, MUTAT RES-REV MUTAT, V787, DOI 10.1016/j.mrrev.2021.108365
   Cena H, 2011, NUTR REV, V69, P745, DOI 10.1111/j.1753-4887.2011.00446.x
   Daenen K, 2019, PEDIATR NEPHROL, V34, P975, DOI 10.1007/s00467-018-4005-4
   Esposito K, 2012, DIABETES CARE, V35, P2402, DOI 10.2337/dc12-0336
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Gluba A, 2013, INT J CARDIOL, V164, P141, DOI 10.1016/j.ijcard.2012.01.013
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Hernández-Ruiz A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11040774
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Ilori TO, 2017, AM J NEPHROL, V45, P338, DOI 10.1159/000464257
   Ilori TO, 2015, AM J NEPHROL, V42, P320, DOI 10.1159/000441623
   Jomova K, 2023, ARCH TOXICOL, V97, P2499, DOI 10.1007/s00204-023-03562-9
   Joo YS, 2020, MAYO CLIN PROC, V95, P293, DOI 10.1016/j.mayocp.2019.06.014
   Kadowaki T, 2022, DIABETES OBES METAB, V24, P2283, DOI 10.1111/dom.14829
   Levey AS, 2009, ANN INTERN MED, V150, P604, DOI 10.7326/0003-4819-150-9-200905050-00006
   Lin LR, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.904001
   Liu YB, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1276940
   Lu Y, 2024, FRONT NUTR, V11, DOI 10.3389/fnut.2024.1375060
   Masenga SK, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24097898
   Molina P, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.654250
   Moreno-Fernández S, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101502
   Nashar K, 2014, DIABET METAB SYND OB, V7, P421, DOI 10.2147/DMSO.S45183
   Ndumele CE, 2023, CIRCULATION, V148, P1636, DOI 10.1161/CIR.0000000000001186
   Ndumele CE, 2023, CIRCULATION, V148, P1606, DOI 10.1161/CIR.0000000000001184
   Noruzi Z, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/5593919
   Park HM, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1226107
   Peng L, 2024, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1320238
   Pingitore A, 2015, NUTRITION, V31, P916, DOI 10.1016/j.nut.2015.02.005
   Rovin BH, 2021, KIDNEY INT, V100, pS1, DOI 10.1016/j.kint.2021.05.021
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Samson SL, 2014, ENDOCRIN METAB CLIN, V43, P1, DOI 10.1016/j.ecl.2013.09.009
   Scurt FG, 2024, OBES REV, V25, DOI 10.1111/obr.13649
   Sebastian SA, 2024, CURR PROB CARDIOLOGY, V49, DOI 10.1016/j.cpcardiol.2023.102344
   Son D, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12020335
   Stevens PE, 2024, KIDNEY INT, V105, pS117, DOI 10.1016/j.kint.2023.10.018
   Tan BL, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112579
   Van Hoydonck PGA, 2002, J NUTR, V132, P756, DOI 10.1093/jn/132.4.756
   Wei J, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0130876
   Xu ZX, 2024, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1233145
   Xu ZX, 2023, FRONT NUTR, V9, DOI 10.3389/fnut.2022.961950
   Yang LX, 2022, NUTRIENTS, V14, DOI 10.3390/nu14030409
   Zammit AR, 2016, CARDIORENAL MED, V6, P108, DOI 10.1159/000441624
   Zhang X, 2017, TRANSL RES, V183, P14, DOI 10.1016/j.trsl.2016.12.004
   Zhou Q, 2024, PREV MED REP, V41, DOI 10.1016/j.pmedr.2024.102704
   Zhu QZ, 2018, NAT REV NEPHROL, V14, P105, DOI 10.1038/nrneph.2017.157
NR 50
TC 0
Z9 0
U1 3
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD SEP 30
PY 2024
VL 11
AR 1442274
DI 10.3389/fnut.2024.1442274
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA J2M1P
UT WOS:001335450800001
PM 39403399
OA gold
DA 2025-06-11
ER

PT J
AU Alokail, MS
   Al-Daghri, N
   Abdulkareem, A
   Draz, HM
   Yakout, SM
   Alnaami, AM
   Sabico, S
   Alenad, AM
   Chrousos, GP
AF Alokail, Majed S.
   Al-Daghri, Nasser
   Abdulkareem, Amal
   Draz, Hossam M.
   Yakout, Sobhy M.
   Alnaami, Abdullah M.
   Sabico, Shaun
   Alenad, Amal M.
   Chrousos, George P.
TI Metabolic syndrome biomarkers and early breast cancer in Saudi women:
   evidence for the presence of a systemic stress response and/or a
   pre-existing metabolic syndrome-related neoplasia risk?
SO BMC CANCER
LA English
DT Article
DE Breast cancer; Saudi women; Adiponectin; Leptin; HDL
ID DENSITY-LIPOPROTEIN CHOLESTEROL; RENIN-ANGIOTENSIN SYSTEM;
   POSTMENOPAUSAL WOMEN; INSULIN-RESISTANCE; INFLAMMATORY MARKERS;
   ADIPONECTIN LEVELS; DIABETES-MELLITUS; ADIPOSE-TISSUE; OBESITY; COHORT
AB Background: Obesity has been linked to many adverse health consequences, including breast cancer. This study aims to determine adipocytokine and other biological changes in recently diagnosed breast cancer patients before therapy is started.
   Methods: A total of 109 female Saudi subjects [56 newly diagnosed, treatment-naive, histologically-confirmed breast cancer cases and 53 age- and BMI-matched controls] were enrolled in this study. Anthropometric data were collected. Serum insulin, adipocytokines and plasminogen activator inhibitor-1 (PAI-1) concentrations were measured using a customized multiplex Luminex assay. Hypersensitive C-Reactive Protein (CRP), tumor necrosis factor-alpha (TNF-alpha), and angiotensin II (ANG II) were measured using ELISA.
   Results: A few days in the diagnosis, breast cancer subjects had significantly higher systolic blood pressure (p = 0.03), glucose (p = 0.01), triglycerides (p = 0.001), leptin (p = 0.044), resistin (p = 0.04), ANG II (p = 0.02), TNF-alpha (p = 0.045), and CRP (p = 0.04) than the controls. On the other hand, HDL (p = 0.01) and adiponectin (p = 0.02) were significantly lower in cancer subjects than controls. A significant association was found between elevated triglycerides (TG) and breast cancer [OR (95% CI), 6.1(1.8, 15.6), p = 0.004], as well as elevated ANG II [OR (95% CI), 5.2(1.2, 14.3), p = 0.03]. On the other hand, aPAI and HDL correlated negatively with breast cancer [OR (95% CI), 0.076(0.01, 0.34), p = 0.001; 0.30(0.09, 0.95), p 0.04, respectively].
   Conclusion: Circulating ANGII and triglycerides were positively associated with early breast cancer. In contrast, HDL-cholesterol correlated negatively with ANG II and aPAI in these patients. This suggests that patients with recently diagnosed breast cancer have biochemical changes consistent with an activated stress response and/or that patients with metabolic syndrome manifestations have a higher risk of developing this disease.
C1 [Alokail, Majed S.; Al-Daghri, Nasser; Draz, Hossam M.; Yakout, Sobhy M.; Alnaami, Abdullah M.; Sabico, Shaun; Chrousos, George P.] King Saud Univ, Coll Sci, Dept Biochem, Biomarkers Res Program, Riyadh 11451, Saudi Arabia.
   [Alokail, Majed S.; Al-Daghri, Nasser] King Saud Univ, Ctr Excellence Biotechnol, Riyadh 11451, Saudi Arabia.
   [Abdulkareem, Amal] King Saud Univ, Coll Med, Dept Surg, Riyadh 11472, Saudi Arabia.
   [Draz, Hossam M.] Natl Res Ctr, Dept Biochem, Cairo 12311, Egypt.
   [Alenad, Amal M.] Univ Southampton, Sch Biol Sci, Southampton SO17 1BJ, Hants, England.
   [Chrousos, George P.] Univ Athens, Sch Med, Dept Pediat 1, Athens 11527, Greece.
   [Al-Daghri, Nasser] King Saud Univ, Coll Sci, Dept Biochem, Riyadh 11451, Saudi Arabia.
C3 King Saud University; King Saud University; King Saud University;
   Egyptian Knowledge Bank (EKB); National Research Centre (NRC);
   University of Southampton; National & Kapodistrian University of Athens;
   Athens Medical School; King Saud University
RP Al-Daghri, N (corresponding author), King Saud Univ, Coll Sci, Dept Biochem, Biomarkers Res Program, Riyadh 11451, Saudi Arabia.
EM aldaghri2011@gmail.com
RI Alnaami, Abdullah/LOR-5409-2024; Al-Daghri, Nasser/A-8360-2011; YAKOUT,
   SOBHY/F-1106-2019; Alenad, Amal/MXM-4730-2025; Al-okail,
   Majed/E-5565-2016; Chrousos, George/G-8702-2011; Sabico,
   Shaun/C-9086-2011
OI Sabico, Shaun/0000-0002-5248-2350; Al-Daghri,
   Nasser/0000-0001-5472-1725; Draz, Hossam/0000-0002-7351-3339
FU King Abdul Aziz City for Science and Technology (KACST), Riyadh, Saudi
   Arabia [AT-28-94]
FX This study was generously funded by King Abdul Aziz City for Science and
   Technology (KACST), (project # AT-28-94) Riyadh, Saudi Arabia. The
   authors thank Mr. Benjamin Vinodson and Mr. SaimUlhaq for the
   statistical analyses of the data.
CR Agnoli C, 2010, NUTR METAB CARDIOVAS, V20, P41, DOI 10.1016/j.numecd.2009.02.006
   Albuquerque K V, 1995, Eur J Surg Oncol, V21, P504, DOI 10.1016/S0748-7983(95)96935-7
   Alokail MS, 2009, CARDIOVASC DIABETOL, V8, DOI 10.1186/1475-2840-8-33
   [Anonymous], 2006, BREAST CANC FACTS FI
   Bozcuk H, 2004, CYTOKINE, V27, P58, DOI 10.1016/j.cyto.2004.04.002
   Calle EE, 2003, NEW ENGL J MED, V348, P1625, DOI 10.1056/NEJMoa021423
   Carmichael AR, 2006, OBES REV, V7, P333, DOI 10.1111/j.1467-789X.2006.00261.x
   Chong YM, 2006, ANTICANCER RES, V26, P167
   Chrousos GP, 2009, NAT REV ENDOCRINOL, V5, P374, DOI 10.1038/nrendo.2009.106
   Dalamaga M, 2011, MENOPAUSE, V18, P1198, DOI 10.1097/gme.0b013e31821e21f5
   Daling JR, 2001, CANCER, V92, P720, DOI 10.1002/1097-0142(20010815)92:4<720::AID-CNCR1375>3.0.CO;2-T
   Deshayes F, 2005, TRENDS ENDOCRIN MET, V16, P293, DOI 10.1016/j.tem.2005.07.009
   Dirat B, 2010, ENDOCR DEV, V19, P45, DOI 10.1159/000316896
   Fischer S, 2002, ACTA DIABETOL, V39, P105, DOI 10.1007/s005920200027
   Furberg AS, 2004, J NATL CANCER I, V96, P1152, DOI 10.1093/jnci/djh216
   George AJ, 2010, NAT REV CANCER, V10, P745, DOI 10.1038/nrc2945
   Gunter MJ, 2009, JNCI-J NATL CANCER I, V101, P48, DOI 10.1093/jnci/djn415
   Haluzík M, 2004, PHYSIOL RES, V53, P123, DOI 10.33549/physiolres.930479
   Han CZ, 2005, ENDOCRINE, V26, P19, DOI 10.1385/ENDO:26:1:019
   Il'yasova D, 2005, CANCER EPIDEM BIOMAR, V14, P2413, DOI 10.1158/1055-9965.EPI-05-0316
   Jafri H, 2010, J AM COLL CARDIOL, V55, P2846, DOI 10.1016/j.jacc.2009.12.069
   Körner A, 2007, J CLIN ENDOCR METAB, V92, P1041, DOI 10.1210/jc.2006-1858
   Krebs EE, 2006, J AM GERIATR SOC, V54, P63, DOI 10.1111/j.1532-5415.2005.00541.x
   Kucharska-Newton AM, 2008, ANN EPIDEMIOL, V18, P671, DOI 10.1016/j.annepidem.2008.06.006
   Larsson SC, 2007, INT J CANCER, V121, P856, DOI 10.1002/ijc.22717
   Macciò A, 2009, OBES REV, V10, P660, DOI 10.1111/j.1467-789X.2009.00592.x
   Melvin JC, 2012, CANC EPIDEMIOL BIOMA
   Michels KB, 2006, ARCH INTERN MED, V166, P2395, DOI 10.1001/archinte.166.21.2395
   Muniyappa R, 2012, MOL CELL ENDOCRINOL
   Muti P, 2002, CANCER EPIDEM BIOMAR, V11, P1361
   Oh SW, 2011, BREAST CANCER RES, V13, DOI 10.1186/bcr2856
   Peeters PHM, 2000, J HYPERTENS, V18, P249, DOI 10.1097/00004872-200018030-00002
   Pichard C, 2008, MATURITAS, V60, P19, DOI 10.1016/j.maturitas.2008.03.002
   Pisani Paola, 2008, Archives of Physiology and Biochemistry, V114, P63, DOI [10.1080/13813450801954451, 10.1080/13813450801954451 ]
   Rapp K, 2006, DIABETOLOGIA, V49, P945, DOI 10.1007/s00125-006-0207-6
   Rodrigues-Ferreira S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035667
   Rolland YM, 2006, METABOLISM, V55, P1630, DOI 10.1016/j.metabol.2006.07.026
   Soler M, 1999, HYPERTENSION, V34, P320, DOI 10.1161/01.HYP.34.2.320
   Tworoger SS, 2007, J CLIN ENDOCR METAB, V92, P1510, DOI 10.1210/jc.2006-1975
   World Health Organisation, 2012, OB OV FACT SHEET
   Xue F, 2007, AM J CLIN NUTR, V86, p823S, DOI 10.1093/ajcn/86.3.823S
   Yuan GY, 2006, DIABETES RES CLIN PR, V72, P244, DOI 10.1016/j.diabres.2005.10.025
   Yvan-Charvet L, 2011, KIDNEY INT, V79, P162, DOI 10.1038/ki.2010.391
   Zhang GJ, 1999, ANTICANCER RES, V19, P1427
NR 44
TC 43
Z9 47
U1 0
U2 17
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2407
J9 BMC CANCER
JI BMC Cancer
PD FEB 4
PY 2013
VL 13
AR 54
DI 10.1186/1471-2407-13-54
PG 6
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 088BE
UT WOS:000314808000001
PM 23374911
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Riccardi, G
   Aggett, P
   Brighenti, F
   Delzenne, N
   Frayn, K
   Nieuwenhuizen, A
   Pannemans, D
   Theis, S
   Tuijtelaars, S
   Vessby, B
AF Riccardi, G
   Aggett, P
   Brighenti, F
   Delzenne, N
   Frayn, K
   Nieuwenhuizen, A
   Pannemans, D
   Theis, S
   Tuijtelaars, S
   Vessby, B
TI PASSCLAIM - Body weight regulation, insulin sensitivity and diabetes
   risk
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Review
DE diet; functional foods; insulin sensitivity; insulin resistance;
   obesity; metabolic syndrome; type 2 diabetes
ID CORONARY-HEART-DISEASE; FREE FATTY-ACIDS; MUSCLE GLYCOGEN-SYNTHESIS;
   ENDOTHELIAL DYSFUNCTION; ENERGY-EXPENDITURE; GLUCOSE-METABOLISM;
   OXIDATIVE STRESS; GLYCEMIC INDEX; ADIPOSE-TISSUE; SKELETAL-MUSCLE
AB Background Insulin sensitivity is a key function in human metabolism because it has a crucial role in the development of disease that are increasingly common in modern society. Impaired insulin sensitivity is an important determinant of type 2 diabetes; moreover, it has been proposed as an independent risk factor for cardiovascular disease. Thus, reduced insulin sensitivity is strongly associated with the metabolic syndrome, which represents a cluster of metabolic abnormalities and cardiovascular risk factor. Insulin sensitivity can be modulated by different environmental factors, including dietary habits. Obesity, especially if associated with abdominal adiposity, impairs insulin-sensitivity while physical activity can improve it; however, the composition of the habitual diet is clearly an important regulator of this function. Aim To evaluate methodologies and markers that can be used to substantiate existing and potential claims of beneficial effects of foods on relevant functions connected with body fat deposition, insulin sensitivity and blood glucose regulation. Results We have reviewed the scientific basis for existing and potential claims, based not only on modifications of the target functions (body fat deposition, insulin sensitivity and blood glucose regulation) but also on modifications of other relevant associated functions (energy intake, energy expenditure, fat storage and oxidation, lipotoxicity, body fat composition, inflammation, oxidative stress, vascular function, glucose production and utilization). In this context we have identified a number of markers and evaluated appropriate method to measure and validate them. Conclusions Relevant functions contributing to overweight, the metabolic syndrome and diabetes have been identified. The evidence reviewed indicates that in this field the link between nutrition, biological responses and diseases is clearly established. Therefore, there is a stromg potential to develop functional food science. The major gap in the evidence continues to be the lack of diet based intervention trials of sufficient duration to be relevant for affecting the natural history of these conditions.
C1 ILSI Europe, B-1200 Brussels, Belgium.
   Uppsala Univ, Dept Publ Hlth & Caring Sci Geriatr, Unit Clin Nutr Res, S-75125 Uppsala, Sweden.
   Sudzucker AG, ZAFES, D-67283 Obrigheim, Germany.
   Univ Naples Federico II, Dipartimento Med Clin & Sperimentale, I-80131 Naples, Italy.
   Univ Cent Lancashire, Lancashire Sch Hlth & Postgrad Med, Preston PR1 2HE, Lancs, England.
   Univ Parma, Inst Hyg, Chair Human Nutr, I-43100 Parma, Italy.
   Catholic Univ Louvain, Dept Pharmaceut Sci, Unite PMNT, B-1200 Brussels, Belgium.
   Univ Oxford, Churchill Hosp, Oxford OX3 7LJ, England.
   Numico Res, NL-6700 CA Wageningen, Netherlands.
C3 Uppsala University; University of Naples Federico II; University of
   Central Lancashire; University of Parma; Universite Catholique Louvain;
   University of Oxford; Danone Nutricia; Royal Numico N.V.
RP ILSI Europe, Ave F Mounier 83,Box 6, B-1200 Brussels, Belgium.
EM publications@ilsieurope.be
RI Delzenne, Nathalie/AAC-4628-2019; riccardi, gabriele/A-9269-2012;
   brighenti, furio/E-4174-2010
OI Frayn, Keith/0000-0001-7281-1863; Delzenne,
   Nathalie/0000-0003-2115-6082; brighenti, furio/0000-0001-8441-4611;
   Nieuwenhuizen, Arie/0000-0003-0999-5422
CR ABATE N, 1995, J CLIN INVEST, V96, P88, DOI 10.1172/JCI118083
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Alberti KGMM, 1996, DIABETIC MED, V13, P927, DOI 10.1002/(SICI)1096-9136(199611)13:11<927::AID-DIA279>3.3.CO;2-5
   ALBU J, 1995, DIABETES REV, V3, P335
   Alford F. P., 1999, Journal of Endocrinological Investigation, V22, P28
   Althuis MD, 2002, AM J CLIN NUTR, V76, P148, DOI 10.1093/ajcn/76.1.148
   Altshuler D, 2000, NAT GENET, V26, P76, DOI 10.1038/79216
   Anderson RA, 2000, DIABETES METAB, V26, P22
   Anderson RA, 1997, DIABETES, V46, P1786, DOI 10.2337/diabetes.46.11.1786
   Anderson RA, 2000, NUTR REV, V58, pS10
   Andrews RC, 1999, CLIN SCI, V96, P513, DOI 10.1042/cs0960513
   [Anonymous], 1995, DIABETES, V44, P968
   Astrup A, 2001, Public Health Nutr, V4, P499
   Astrup A, 1999, BEST PRACT RES CL EN, V13, P109, DOI 10.1053/beem.1999.0009
   Atkinson MA, 2001, LANCET, V358, P221, DOI 10.1016/S0140-6736(01)05415-0
   Aydin A, 2001, CLIN BIOCHEM, V34, P65, DOI 10.1016/S0009-9120(00)00199-5
   Bagchi D, 2002, TOXICOLOGY, V180, P5, DOI 10.1016/S0300-483X(02)00378-5
   Balkau B, 1999, DIABETIC MED, V16, P442
   Balkau B, 2002, DIABETES METAB, V28, P364
   Balletshofer BM, 2001, HORM METAB RES, V33, P428, DOI 10.1055/s-2001-16235
   BARBERA A, 1994, J BIOL CHEM, V269, P20047
   Baron AD, 2000, DIABETES, V49, P768, DOI 10.2337/diabetes.49.5.768
   Basu A, 2001, DIABETES, V50, P1351, DOI 10.2337/diabetes.50.6.1351
   BAUMGARTNER RN, 1991, AM J CLIN NUTR, V53, P1345, DOI 10.1093/ajcn/53.6.1345
   Bell SJ, 2002, CRIT REV FOOD SCI, V42, P163, DOI 10.1080/10408690290825501
   Bellisle F, 1998, BRIT J NUTR, V80, pS173, DOI 10.1079/BJN19980109
   Beltowski Jerzy, 2003, Med Sci Monit, V9, pRA55
   BERGMAN RN, 1981, J CLIN INVEST, V68, P1456, DOI 10.1172/JCI110398
   BJORNTORP P, 1992, ANN MED, V24, P15, DOI 10.3109/07853899209164140
   Björntorp P, 2000, INT J OBESITY, V24, pS80, DOI 10.1038/sj.ijo.0801285
   Björntorp P, 1999, ANN NY ACAD SCI, V892, P297, DOI 10.1111/j.1749-6632.1999.tb07803.x
   BLUNDELL JE, 1991, ENCY HUMAN BIOL, V6, P723
   BODEN G, 1994, J CLIN INVEST, V93, P2438, DOI 10.1172/JCI117252
   Boden G, 1996, METABOLISM, V45, P1130, DOI 10.1016/S0026-0495(96)90013-X
   Boden G, 2001, DIABETES, V50, P1612, DOI 10.2337/diabetes.50.7.1612
   Boden G, 2002, EUR J CLIN INVEST, V32, P14, DOI 10.1046/j.1365-2362.32.s3.3.x
   BONADONNA RC, 1991, DIABETES METAB, V17, P112
   BONADONNA RC, 1993, J CLIN INVEST, V92, P486, DOI 10.1172/JCI116592
   Bonnefont-Rousselot D, 2002, CURR OPIN CLIN NUTR, V5, P561, DOI 10.1097/00075197-200209000-00016
   Borch-Johnsen K, 1999, LANCET, V354, P617
   BROWN RO, 1986, DIGEST DIS SCI, V31, P661, DOI 10.1007/BF01318699
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   BUTLER PC, 1989, ENDOCRIN METAB CLIN, V18, P1
   Calles-Escandon J, 2001, ENDOCR REV, V22, P36, DOI 10.1210/er.22.1.36
   Ceddia RB, 2001, FRONT BIOSCI-LANDMRK, V6, pD90, DOI 10.2741/ceddia
   Ceriello A, 2000, METABOLISM, V49, P27, DOI 10.1016/S0026-0495(00)80082-7
   Ceriello A, 2002, CIRCULATION, V106, P1211, DOI 10.1161/01.CIR.0000027569.76671.A8
   Chagnon YC, 2003, OBES RES, V11, P313, DOI 10.1038/oby.2003.47
   Chausmer AB, 1998, J AM COLL NUTR, V17, P109, DOI 10.1080/07315724.1998.10718735
   Chiasson JL, 2002, LANCET, V359, P2072, DOI 10.1016/S0140-6736(02)08905-5
   Choi BCK, 2001, DIABETOLOGIA, V44, P1221, DOI 10.1007/s001250100648
   Christensen JO, 1998, INT J OBESITY, V22, P195, DOI 10.1038/sj.ijo.0800566
   Clark MG, 2003, AM J PHYSIOL-ENDOC M, V284, pE241, DOI 10.1152/ajpendo.00408.2002
   Clasey JL, 1999, J APPL PHYSIOL, V86, P1728, DOI 10.1152/jappl.1999.86.5.1728
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cline GW, 1999, NEW ENGL J MED, V341, P240, DOI 10.1056/NEJM199907223410404
   Coppack SW, 1996, CLIN SCI, V90, P409, DOI 10.1042/cs0900409
   Cota D, 2003, INT J OBESITY, V27, P289, DOI 10.1038/sj.ijo.0802250
   Cracowski JL, 2002, TRENDS PHARMACOL SCI, V23, P360, DOI 10.1016/S0165-6147(02)02053-9
   Cummings DE, 2003, ANNU REV MED, V54, P513, DOI 10.1146/annurev.med.54.101601.152147
   Cusi K, 2001, J CLIN ENDOCR METAB, V86, P1410, DOI 10.1210/jc.86.3.1410
   Daly ME, 1998, AM J CLIN NUTR, V67, P1186, DOI 10.1093/ajcn/67.6.1186
   Dandona P, 2002, AM J CARDIOL, V90, p27G
   Das UN, 2001, NUTRITION, V17, P953, DOI 10.1016/S0899-9007(01)00672-4
   de Vegt F, 2001, JAMA-J AM MED ASSOC, V285, P2109, DOI 10.1001/jama.285.16.2109
   DEFRONZO RA, 1989, METABOLISM, V38, P387, DOI 10.1016/0026-0495(89)90129-7
   DEFRONZO RA, 1979, AM J PHYSIOL, V237, pE214
   DEURENBERG P, 1991, BRIT J NUTR, V65, P105, DOI 10.1079/BJN19910073
   Dhillo Waljit S., 2001, Current Opinion in Pharmacology, V1, P651, DOI 10.1016/S1471-4892(01)00110-2
   Doucet E, 1997, EUR J CLIN NUTR, V51, P846, DOI 10.1038/sj.ejcn.1600497
   DRAZNIN B, 1993, AM J KIDNEY DIS, V21, P32
   Drucker DJ, 2001, ENDOCRINOLOGY, V142, P521, DOI 10.1210/en.142.2.521
   Drucker DJ, 2002, GASTROENTEROLOGY, V122, P531, DOI 10.1053/gast.2002.31068
   Dye L, 2002, BRIT J NUTR, V88, pS187, DOI 10.1079/BJN2002684
   Edelstein SL, 1997, DIABETES, V46, P701, DOI 10.2337/diabetes.46.4.701
   EIBL NL, 1995, DIABETES CARE, V18, P188, DOI 10.2337/diacare.18.2.188
   Farkas K, 2000, DIABETES NUTR METAB, V13, P287
   FAURE P, 1992, BIOL TRACE ELEM RES, V32, P305, DOI 10.1007/BF02784615
   FAURE P, 1991, DIABETES METAB, V17, P325
   FERRANNINI E, 1983, J CLIN INVEST, V72, P1737, DOI 10.1172/JCI111133
   FERY F, 1990, AM J PHYSIOL, V259, pE770, DOI 10.1152/ajpendo.1990.259.6.E770
   FERY F, 1993, METABOLISM, V42, P522, DOI 10.1016/0026-0495(93)90113-3
   FERY F, 1994, DIABETES, V43, P1418, DOI 10.2337/diabetes.43.12.1418
   Feskens EJM, 2001, DIABETES CARE, V24, P1517, DOI 10.2337/diacare.24.9.1517
   Flint A, 1998, J CLIN INVEST, V101, P515, DOI 10.1172/JCI990
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Forouhi NG, 1999, DIABETOLOGIA, V42, P932, DOI 10.1007/s001250051250
   Frayn Keith N., 1997, P101
   Frayn KN, 1996, CLIN SCI, V90, P243, DOI 10.1042/cs0900243
   FURNSINN C, 1997, AM J PHYSIOL, V273, P514
   Gavin JR, 1997, DIABETES CARE, V20, P1183
   Giacco R, 2003, INT J OBESITY, V27, P790, DOI 10.1038/sj.ijo.0802306
   Giacco R, 2001, BRIT J NUTR, V85, P33, DOI 10.1079/BJN2000218
   Gillum RF, 2000, J CLIN EPIDEMIOL, V53, P511, DOI 10.1016/S0895-4356(99)00208-5
   GLATZ PCG, 1989, AM J CLIN NUTR, V49, P296
   Golay A, 1997, INT J OBESITY, V21, pS2
   Goldstein DE, 2004, DIABETES CARE, V27, P1761, DOI 10.2337/diacare.27.7.1761
   Goran MI, 2000, MED CLIN N AM, V84, P347, DOI 10.1016/S0025-7125(05)70225-X
   GOTO T, 1995, INT J OBESITY, V19, P841
   GRIFFITHS HR, 2002, BIOMARKERS MOL ASPEC, V1, P101
   Grimble RF, 2002, CURR OPIN CLIN NUTR, V5, P551, DOI 10.1097/00075197-200209000-00015
   Grundy SM, 1999, AM J CARDIOL, V83, p25F
   Haffner SM, 1998, NEW ENGL J MED, V339, P229, DOI 10.1056/NEJM199807233390404
   Haffner SM, 2000, INT J OBESITY, V24, pS56, DOI 10.1038/sj.ijo.0801279
   HAK A, 2000, J CLIN ENDOCR METAB, V86, P4398
   Hauner H, 2001, INT J OBESITY, V25, pS102, DOI 10.1038/sj.ijo.0801711
   Hauptman J, 2000, ENDOCRINE, V13, P201, DOI 10.1385/ENDO:13:2:201
   Havel PJ, 2002, CURR OPIN LIPIDOL, V13, P51, DOI 10.1097/00041433-200202000-00008
   Heidland A, 2001, AM J KIDNEY DIS, V38, pS100, DOI 10.1053/ajkd.2001.27414
   HENRY RR, 1986, DIABETES, V35, P990, DOI 10.2337/diabetes.35.9.990
   HEYMSFIELD SB, 1990, AM J CLIN NUTR, V52, P52, DOI 10.1093/ajcn/52.1.52
   HILL AJ, 1990, PHYSIOL BEHAV, V48, P241, DOI 10.1016/0031-9384(90)90307-P
   Hill JO, 2002, BRIT J NUTR, V88, pS213, DOI [10.1079/BJN2002685, 10.1079/BJNBJN2002604]
   Himaya A, 1997, AM J CLIN NUTR, V65, P1410, DOI 10.1093/ajcn/65.5.1410
   Hirashima O, 2000, J AM COLL CARDIOL, V35, P1860, DOI 10.1016/S0735-1097(00)00616-1
   Hofbauer K, 2002, INT J OBESITY, V26, pS18, DOI 10.1038/sj.ijo.0802124
   Holt RIG, 2003, DIABETIC MED, V20, P3, DOI 10.1046/j.1464-5491.2003.00827.x
   HOLT SHA, 1995, EUR J CLIN NUTR, V49, P675
   Hu FB, 2001, DIABETOLOGIA, V44, P805, DOI 10.1007/s001250100547
   Huerta Milagros G, 2002, Curr Diab Rep, V2, P396, DOI 10.1007/s11892-002-0103-5
   Inouye M, 2000, ATHEROSCLEROSIS, V148, P197, DOI 10.1016/S0021-9150(99)00263-4
   JACKSON AS, 1978, BRIT J NUTR, V40, P497, DOI 10.1079/BJN19780152
   JACKSON AS, 1980, MED SCI SPORT EXER, V12, P175
   Jacob S, 1996, DIABETES, V45, P1024, DOI 10.2337/diabetes.45.8.1024
   JENKINS DJA, 1981, AM J CLIN NUTR, V34, P362, DOI 10.1093/ajcn/34.3.362
   JEQUIER E, 1987, BAILLIERE CLIN ENDOC, V1, P911, DOI 10.1016/S0950-351X(87)80011-3
   Jones RD, 2000, FREE RADICAL BIO MED, V29, P416, DOI 10.1016/S0891-5849(00)00320-8
   JUHEL C, 2000, J NUTR BIOCH, V11, pS51
   Kañková K, 2001, J DIABETES COMPLICAT, V15, P185, DOI 10.1016/S1056-8727(00)00135-5
   Karpe F, 2002, DIABETES, V51, P2467, DOI 10.2337/diabetes.51.8.2467
   Kataria J. M., 1997, Indian Journal of Comparative Microbiology, Immunology and Infectious Diseases, V18, P38
   Katusic ZS, 2001, AM J PHYSIOL-HEART C, V281, pH981, DOI 10.1152/ajpheart.2001.281.3.H981
   Kelley DE, 1996, J CLIN INVEST, V97, P2705, DOI 10.1172/JCI118724
   Kersten S, 2000, NATURE, V405, P421, DOI 10.1038/35013000
   King H, 1998, DIABETES CARE, V21, P1414, DOI 10.2337/diacare.21.9.1414
   KISSEBAH AH, 1994, PHYSIOL REV, V74, P761, DOI 10.1152/physrev.1994.74.4.761
   KISSILEFF HR, 1981, AM J CLIN NUTR, V34, P154, DOI 10.1093/ajcn/34.2.154
   Knowler William C, 2002, N Engl J Med, V346, P393, DOI 10.1056/NEJMoa012512
   Koyama K, 1997, AM J PHYSIOL-ENDOC M, V273, pE708, DOI 10.1152/ajpendo.1997.273.4.E708
   LAGER I, 1991, J INTERN MED, V229, P41
   Landsberg L, 1999, ANN NY ACAD SCI, V892, P84, DOI 10.1111/j.1749-6632.1999.tb07787.x
   Lee HM, 2002, ENDOCRINOLOGY, V143, P185, DOI 10.1210/en.143.1.185
   Levine JA, 2000, AM J CLIN NUTR, V72, P1451
   Levine James A., 1999, Science (Washington D C), V283, P212, DOI 10.1126/science.283.5399.212
   LILLIOJA S, 1993, NEW ENGL J MED, V329, P1988, DOI 10.1056/NEJM199312303292703
   Lima MDL, 1998, DIABETES CARE, V21, P682, DOI 10.2337/diacare.21.5.682
   Lissner L, 2000, BRIT J NUTR, V83, pS21
   Little P, 1999, J EPIDEMIOL COMMUN H, V53, P165, DOI 10.1136/jech.53.3.165
   Liu SM, 2000, AM J CLIN NUTR, V71, P1455
   Livingstone C, 2002, CLIN SCI, V102, P151, DOI 10.1042/cs1020151
   Ludwig DS, 2001, LANCET, V357, P505, DOI 10.1016/S0140-6736(00)04041-1
   Ludwig DS, 2002, JAMA-J AM MED ASSOC, V287, P2414, DOI 10.1001/jama.287.18.2414
   LUKASKI HC, 1986, J APPL PHYSIOL, V60, P1327, DOI 10.1152/jappl.1986.60.4.1327
   MA J, 1995, AM J CLIN NUTR, V62, P564, DOI 10.1093/ajcn/62.3.564
   Maggio CA, 1997, DIABETES CARE, V20, P1744, DOI 10.2337/diacare.20.11.1744
   Masuzaki H, 2001, SCIENCE, V294, P2166, DOI 10.1126/science.1066285
   Mather KJ, 2001, J CLIN ENDOCR METAB, V86, P5457, DOI 10.1210/jc.86.11.5457
   MATSUDA M, 1997, CLIN RES DIABETES OB, V1, P23
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mayer-Davis EJ, 2002, DIABETES CARE, V25, P2172, DOI 10.2337/diacare.25.12.2172
   McCrory MA, 1997, AM J CLIN NUTR, V66, P18, DOI 10.1093/ajcn/66.1.18
   McMinn J E, 2000, Obes Rev, V1, P37, DOI 10.1046/j.1467-789x.2000.00007.x
   McVeigh Gary E, 2003, Curr Diab Rep, V3, P87, DOI 10.1007/s11892-003-0059-0
   Mechoulam R, 2001, NATURE, V410, P763, DOI 10.1038/35071214
   Mensink RP, 2003, EUR J NUTR, V42, P6, DOI 10.1007/s00394-003-1102-2
   MOLLER N, 1991, HORM RES, V36, P32, DOI 10.1159/000182185
   Montagne CT, 2000, DIABETES, V49, P883, DOI 10.2337/diabetes.49.6.883
   Muccioli G, 2002, EUR J PHARMACOL, V440, P235, DOI 10.1016/S0014-2999(02)01432-2
   Muñoz MC, 2001, DIABETES, V50, P131, DOI 10.2337/diabetes.50.1.131
   NAGI DK, 1995, DIABETOLOGIA, V38, P187, DOI 10.1007/BF00400093
   Nakazato M, 2001, NATURE, V409, P194, DOI 10.1038/35051587
   National Institutes of Health, 2000, NIH PUBL, P1
   NIKKARI T, 1995, ANN MED, V27, P491, DOI 10.3109/07853899509002458
   Oliver WR, 2001, P NATL ACAD SCI USA, V98, P5306, DOI 10.1073/pnas.091021198
   PAOLISSO G, 1995, J AM COLL NUTR, V14, P387
   PAOLISSO G, 1989, DIABETES CARE, V12, P265, DOI 10.2337/diacare.12.4.265
   Pérez-Jiménez F, 2001, DIABETOLOGIA, V44, P2038, DOI 10.1007/s001250100009
   Perticone F, 2001, DIABETES, V50, P159, DOI 10.2337/diabetes.50.1.159
   Phillips DIW, 1996, METABOLISM, V45, P947, DOI 10.1016/S0026-0495(96)90260-7
   PIERSON RN, 1984, AM J PHYSIOL, V246, pF234, DOI 10.1152/ajprenal.1984.246.2.F234
   Pleiner J, 2002, J CLIN ENDOCR METAB, V87, P2913, DOI 10.1210/jc.87.6.2913
   POLONSKY KS, 2001, ENDOCRINOLOGY
   RABEN A, 1994, AM J PHYSIOL-ENDOC M, V267, pE549, DOI 10.1152/ajpendo.1994.267.4.E549
   RANDLE PJ, 1963, LANCET, V1, P785
   Ravussin E, 2002, ANN NY ACAD SCI, V967, P363
   RAVUSSIN E, 1991, AM J PHYSIOL, V261, pE402, DOI 10.1152/ajpendo.1991.261.3.E402
   REACH G, 1979, DIABETES METAB, V5, P63
   REAVEN GM, 1985, J CLIN ENDOCR METAB, V61, P32, DOI 10.1210/jcem-61-1-32
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   REAVEN GM, 1988, DIABETES, V37, P1020, DOI 10.2337/diabetes.37.8.1020
   Reaven GM., 2001, Handbook of physiology. Section 7: The endocrine system. Vol. II: The endocrine pancreas and regulation of metabolism, VII, P1169
   Riccardi G, 2003, NUTR REV, V61, pS56, DOI 10.1301/nr.2003.may.S56-S60
   RIZZA RA, 2000, MAYO CLIN P, V75, P61
   Roberts SB, 2000, NUTR REV, V58, P163, DOI 10.1111/j.1753-4887.2000.tb01855.x
   Rodríguez-Morán M, 2003, DIABETES CARE, V26, P1147, DOI 10.2337/diacare.26.4.1147
   Rolls BJ, 2000, J NUTR, V130, p268S, DOI 10.1093/jn/130.2.268S
   Ross R, 1996, CAN J PHYSIOL PHARM, V74, P778, DOI 10.1139/cjpp-74-6-778
   ROSSNER S, 1990, INT J OBESITY, V14, P893
   Ruhe RC, 2001, J AM COLL NUTR, V20, p363S, DOI 10.1080/07315724.2001.10719169
   Ryysy L, 2000, DIABETES, V49, P749, DOI 10.2337/diabetes.49.5.749
   Salmeron J, 1997, JAMA-J AM MED ASSOC, V277, P472, DOI 10.1001/jama.277.6.472
   Saltiel AR, 2001, NATURE, V414, P799, DOI 10.1038/414799a
   SALTZMAN E, 1995, NUTR REV, V53, P209, DOI 10.1111/j.1753-4887.1995.tb01554.x
   Samaras K, 2000, DIABETES CARE, V23, P441, DOI 10.2337/diacare.23.4.441
   SanchezLugo L, 1997, AM J CLIN NUTR, V66, P1224, DOI 10.1093/ajcn/66.5.1224
   SARIS WH, 1998, INT J OBES RELAT S2, V22, pW15
   Saris WHM, 1998, BRIT J NUTR, V80, pS47, DOI 10.1079/BJN19980105
   Saris WHM, 2003, EUR J NUTR, V42, P50, DOI [10.1007/s00394-003-1104-0, 10.1007/s00394-003-0399-1]
   Sato J, 2002, ATHEROSCLEROSIS, V161, P327, DOI 10.1016/S0021-9150(01)00649-9
   SCHOELLER DA, 1988, J NUTR, V118, P1278, DOI 10.1093/jn/118.11.1278
   Schoeller DA, 1998, AM J CLIN NUTR, V68, p956S, DOI 10.1093/ajcn/68.4.956S
   Schrauwen P, 1999, OBES RES, V7, P97, DOI 10.1002/j.1550-8528.1999.tb00396.x
   Schutz Y, 1997, Z ERNAHRUNGSWISS, V36, P255, DOI 10.1007/BF01617794
   SCHUTZ Y, 1995, METABOLISM, V44, P7, DOI 10.1016/0026-0495(95)90311-9
   Seppälä-Lindroos A, 2002, J CLIN ENDOCR METAB, V87, P3023, DOI 10.1210/jc.87.7.3023
   SHAMOON H, 1993, NEW ENGL J MED, V329, P977, DOI 10.1056/NEJM199307293290502
   Sherwin Robert S, 2003, Diabetes Care, V26 Suppl 1, pS62
   SHILS M.E., 1994, MODERN NUTR HLTH DIS, V8th
   SHULMAN GI, 1990, NEW ENGL J MED, V322, P223, DOI 10.1056/NEJM199001253220403
   Sievenpiper JL, 2001, AM J CLIN NUTR, V73, P567
   SKARFORS ET, 1991, BRIT MED J, V303, P755, DOI 10.1136/bmj.303.6805.755
   Soonthornpun S, 2003, J CLIN ENDOCR METAB, V88, P1019, DOI 10.1210/jc.2002-021127
   STAMLER J, 1993, DIABETES CARE, V16, P434, DOI 10.2337/diacare.16.2.434
   Stapleton SR, 2000, CELL MOL LIFE SCI, V57, P1874, DOI 10.1007/PL00000669
   Stearns DM, 1995, FASEB J, V9, P1643, DOI 10.1096/fasebj.9.15.8529845
   Stefan N, 2002, HORM METAB RES, V34, P469, DOI 10.1055/s-2002-34785
   STEIL GM, 1993, DIABETES, V42, P250, DOI 10.2337/diabetes.42.2.250
   Steppan CM, 2001, NATURE, V409, P307, DOI 10.1038/35053000
   Storlien LH, 2000, BRIT J NUTR, V83, pS85
   STORLIEN LH, 1991, DIABETES, V40, P280, DOI 10.2337/diabetes.40.2.280
   STRIFFLER JS, 1995, METABOLISM, V44, P1314, DOI 10.1016/0026-0495(95)90036-5
   Stubbs J, 2000, CRIT REV FOOD SCI, V40, P481, DOI 10.1080/10408690091189248
   Stubbs RJ, 1999, NUTRITION, V15, P614, DOI 10.1016/S0899-9007(99)00098-2
   Summers LKM, 2002, DIABETOLOGIA, V45, P369, DOI 10.1007/s00125-001-0768-3
   Svensson J, 2002, J CLIN ENDOCR METAB, V87, P2121, DOI 10.1210/jc.87.5.2121
   Teegarden D, 2003, J NUTR, V133, p249S, DOI 10.1093/jn/133.1.249S
   Temelkova-Kurktschiev T, 2002, METABOLISM, V51, P743, DOI 10.1053/meta.2002.32804
   Trabulsi J, 2001, AM J PHYSIOL-ENDOC M, V281, pE891, DOI 10.1152/ajpendo.2001.281.5.E891
   TRAN ZV, 1988, HUM BIOL, V60, P167
   TRAN ZV, 1989, MED SCI SPORT EXER, V21, P101, DOI 10.1249/00005768-198902000-00018
   Tripathy D, 2003, DIABETOLOGIA, V46, P300, DOI 10.1007/s00125-002-1027-y
   Tschöp M, 2002, ENDOCRINOLOGY, V143, P558, DOI 10.1210/en.143.2.558
   Tuomilehto J, 2001, NEW ENGL J MED, V344, P1343, DOI 10.1056/NEJM200105033441801
   Turner RC, 1998, LANCET, V352, P837, DOI 10.1016/s0140-6736(98)07019-6
   Ukkola O, 2002, EUR J ENDOCRINOL, V147, P571, DOI 10.1530/eje.0.1470571
   *UKPDS 23, 1998, BMJ-BRIT MED J, V16, P823
   Unger R H, 1982, Compr Ther, V8, P53
   UUSITUPA MIJ, 1993, DIABETOLOGIA, V36, P1175, DOI 10.1007/BF00401063
   Vaccaro O, 2000, INT J OBESITY, V24, P1195, DOI 10.1038/sj.ijo.0801366
   Valtuena S, 1997, INT J OBESITY, V21, P811, DOI 10.1038/sj.ijo.0800480
   van Dam RM, 2002, ANN INTERN MED, V136, P201, DOI 10.7326/0003-4819-136-3-200202050-00008
   VANITALLIE TB, 1985, ANN INTERN MED, V103, P983, DOI 10.7326/0003-4819-103-6-983
   VANKREEL BK, 1994, CLIN CHIM ACTA, V231, P117
   VanKreel BK, 1996, J MASS SPECTROM, V31, P108
   Verma S, 1998, J AM COLL NUTR, V17, P11, DOI 10.1080/07315724.1998.10718730
   Vessby B, 2000, BRIT J NUTR, V83, pS91
   Vessby B, 2002, ANN NY ACAD SCI, V967, P183
   Vessby B, 2001, DIABETOLOGIA, V44, P312, DOI 10.1007/s001250051620
   Vincent JB, 2000, J NUTR, V130, P715, DOI 10.1093/jn/130.4.715
   Virtanen KA, 2001, DIABETOLOGIA, V44, P2171, DOI 10.1007/s001250100026
   Walker BR, 2001, BEST PRACT RES CL EN, V15, P111, DOI 10.1053/beem.2000.0123
   WALKER M, 1997, INT TXB DIABETES MEL, P595
   Wang GY, 2002, REGUL PEPTIDES, V105, P75, DOI 10.1016/S0167-0115(02)00012-5
   Wang J, 2003, AM J CLIN NUTR, V77, P379, DOI 10.1093/ajcn/77.2.379
   WANG ZM, 1995, AM J CLIN NUTR, V61, P457, DOI 10.1093/ajcn/61.3.457
   Wang ZM, 1999, AM J PHYSIOL-ENDOC M, V276, pE995, DOI 10.1152/ajpendo.1999.276.6.E995
   Weck M., 1998, Aktuelle Ernahrungsmedizin, V23, P166
   WEIR JBD, 1949, J PHYSIOL-LONDON, V109, P1, DOI 10.1113/jphysiol.1949.sp004363
   Westerterp KR, 2002, CURR OPIN CLIN NUTR, V5, P489, DOI 10.1097/00075197-200209000-00006
   WILLIAMS DP, 1992, AM J HUM BIOL, V4, P595, DOI 10.1002/ajhb.1310040505
   Wolf G, 2002, NUTR REV, V60, P148
   Wolk A, 2001, J NUTR, V131, P828, DOI 10.1093/jn/131.3.828
   World Health Organization, 1999, WHO Technical Report Series, V894
   WORM D, 1994, J CLIN ENDOCR METAB, V78, P717, DOI 10.1210/jc.78.3.717
   Yao MJ, 2001, NUTR REV, V59, P247
   Yasunari K, 2002, HYPERTENSION, V39, P777, DOI 10.1161/hy0302.104670
   Yeh GY, 2003, DIABETES CARE, V26, P1277, DOI 10.2337/diacare.26.4.1277
   YOUNG JB, 1992, INT J OBESITY, V16, P959
   Yuen K, 2002, CLIN ENDOCRINOL, V57, P333, DOI 10.1046/j.1365-2265.2002.01601.x
   Zemel MB, 2003, J NUTR, V133, p252S, DOI 10.1093/jn/133.1.252S
   ZEMEL MB, 1995, J NUTR, V125, pS1738
   Zethelius B, 2003, DIABETOLOGIA, V46, pA76
NR 282
TC 35
Z9 39
U1 1
U2 13
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD JUN
PY 2004
VL 43
SU 2
BP 7
EP 46
DI 10.1007/s00394-004-1202-7
PG 40
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 918QU
UT WOS:000228563500002
PM 15221353
DA 2025-06-11
ER

PT J
AU Zhou, YW
   Li, HG
   Xia, N
AF Zhou, Yawen
   Li, Huige
   Xia, Ning
TI The Interplay Between Adipose Tissue and Vasculature: Role of Oxidative
   Stress in Obesity
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE reactive oxygen species; adipokines; antioxidant; perivascular adipose
   tissue; vascular dysfunction
ID NITRIC-OXIDE SYNTHASE; BOUND INHIBITOR BAMBI; HIGH-FAT; ENDOTHELIAL
   DYSFUNCTION; INSULIN-RESISTANCE; BODY-WEIGHT; MITOCHONDRIAL DYSFUNCTION;
   NUTRITIONAL DEFICIENCIES; PROTEIN CARBONYLATION; HYDROGEN-PEROXIDE
AB Cardiovascular diseases (CVDs) rank the leading cause of morbidity and mortality globally. Obesity and its related metabolic syndrome are well-established risk factors for CVDs. Therefore, understanding the pathophysiological role of adipose tissues is of great importance in maintaining cardiovascular health. Oxidative stress, characterized by excessive formation of reactive oxygen species, is a common cellular stress shared by obesity and CVDs. While plenty of literatures have illustrated the vascular oxidative stress, very few have discussed the impact of oxidative stress in adipose tissues. Adipose tissues can communicate with vascular systems, in an endocrine and paracrine manner, through secreting several adipocytokines, which is largely dysregulated in obesity. The aim of this review is to summarize current understanding of the relationship between oxidative stress in obesity and vascular endothelial dysfunction. In this review, we briefly describe the possible causes of oxidative stress in obesity, and the impact of obesity-induced oxidative stress on adipose tissue function. We also summarize the crosstalk between adipose tissue and vasculature mediated by adipocytokines in vascular oxidative stress. In addition, we highlight the potential target mediating adipose tissue oxidative stress.
C1 [Zhou, Yawen; Li, Huige; Xia, Ning] Johannes Gutenberg Univ Med Ctr, Dept Pharmacol, Mainz, Germany.
C3 Johannes Gutenberg University of Mainz
RP Xia, N (corresponding author), Johannes Gutenberg Univ Med Ctr, Dept Pharmacol, Mainz, Germany.
EM xianing@uni-mainz.de
RI Zhou, Chunyan/H-1529-2016; Li, Huige/M-2662-2013; Xia, Dr.,
   Ning/P-3535-2015
OI Li, Huige/0000-0003-3458-7391; Xia, Dr., Ning/0000-0002-5553-1752
FU Deutsche Forschungsgemeinschaft (DFG), Bonn, Germany [LI-1042/1-1,
   LI-1042/3-1, LI-1042/5-1, XI 139/2-1]; Boehringer Ingelheim Foundation
FX Original works from the authors' laboratory contributing to this review
   were supported by grants LI-1042/1-1, LI-1042/3-1, LI-1042/5-1, and XI
   139/2-1 from the Deutsche Forschungsgemeinschaft (DFG), Bonn, Germany.
   HL and NX were supported by a research grant from the Boehringer
   Ingelheim Foundation for the collaborative research consortium Novel and
   neglected cardiovascular risk factors: molecular mechanisms and
   therapeutic implications.
CR Abraham TM, 2015, CIRCULATION, V132, P1639, DOI 10.1161/CIRCULATIONAHA.114.015000
   Agil A, 2011, J PINEAL RES, V50, P207, DOI 10.1111/j.1600-079X.2010.00830.x
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alcalá M, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-16463-6
   Aldiss P., 2019, BIORXIV, P649061, DOI 10.1101/649061
   Aldiss P, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00097
   Anderson EJ, 2009, J CLIN INVEST, V119, P573, DOI 10.1172/JCI37048
   [Anonymous], 2006, OB OV
   [Anonymous], 2017, OXID MED CELL LONGEV, DOI DOI 10.1155/2017/9410954
   Antoniades C, 2009, OBES REV, V10, P269, DOI 10.1111/j.1467-789X.2009.00571.x
   Antonopoulos AS, 2015, DIABETES, V64, P2207, DOI 10.2337/db14-1011
   Arkin JM, 2008, AM J CARDIOL, V101, P98, DOI 10.1016/j.amjcard.2007.07.055
   Awata WMC, 2019, EUR J PHARMACOL, V863, DOI 10.1016/j.ejphar.2019.172706
   Bailey-Downs LC, 2013, J GERONTOL A-BIOL, V68, P780, DOI 10.1093/gerona/gls238
   Bakker SJL, 2000, ATHEROSCLEROSIS, V148, P17, DOI 10.1016/S0021-9150(99)00329-9
   Bartelt A, 2011, NAT MED, V17, P200, DOI 10.1038/nm.2297
   Bedard K, 2007, PHYSIOL REV, V87, P245, DOI 10.1152/physrev.00044.2005
   Blüher M, 2019, NAT REV ENDOCRINOL, V15, P288, DOI 10.1038/s41574-019-0176-8
   Bonnefont-Rousselot D, 2014, ENDOCR METAB IMMUNE, V14, P159, DOI 10.2174/1871530314666140604151452
   Bordicchia M, 2012, J CLIN INVEST, V122, P1022, DOI 10.1172/JCI59701
   Bouloumié A, 1999, FASEB J, V13, P1231, DOI 10.1096/fasebj.13.10.1231
   Boyer F, 2016, BIOCHEM BIOPH RES CO, V473, P154, DOI 10.1016/j.bbrc.2016.03.068
   Brown NK, 2014, ARTERIOSCL THROM VAS, V34, P1621, DOI 10.1161/ATVBAHA.114.303029
   Cadenas S, 2018, BBA-BIOENERGETICS, V1859, P940, DOI 10.1016/j.bbabio.2018.05.019
   Cao J, 2012, HYPERTENSION, V60, P467, DOI 10.1161/HYPERTENSIONAHA.112.193805
   Chang L, 2018, CIRCULATION, V138, P67, DOI 10.1161/CIRCULATIONAHA.117.029972
   Chang L, 2013, CIRC J, V77, P11, DOI 10.1253/circj.CJ-12-1393
   Chang L, 2012, CIRCULATION, V126, P1067, DOI 10.1161/CIRCULATIONAHA.112.104489
   Chattopadhyay M, 2015, MOL CELL BIOCHEM, V399, P95, DOI 10.1007/s11010-014-2236-7
   Chen H, 2003, J BIOL CHEM, V278, P45021, DOI 10.1074/jbc.M307878200
   Chen XC, 2021, J BIOL CHEM, V296, DOI 10.1074/jbc.RA120.014793
   Chouchani ET, 2017, J BIOL CHEM, V292, P16810, DOI 10.1074/jbc.R117.789628
   Chouchani ET, 2016, NATURE, V532, P112, DOI 10.1038/nature17399
   Cipolla-Neto J, 2014, J PINEAL RES, V56, P371, DOI 10.1111/jpi.12137
   Costa RM, 2016, VASC PHARMACOL, V84, P28, DOI 10.1016/j.vph.2016.05.008
   Curtis JM, 2010, DIABETES, V59, P1132, DOI 10.2337/db09-1105
   Cybularz M, 2017, ATHEROSCLEROSIS SUPP, V30, P149, DOI 10.1016/j.atherosclerosissup.2017.05.042
   da Costa RM, 2017, BRIT J PHARMACOL, V174, P3527, DOI 10.1111/bph.13687
   de Mello AH, 2018, LIFE SCI, V192, P26, DOI 10.1016/j.lfs.2017.11.019
   Den Hartigh LJ, 2017, ARTERIOSCL THROM VAS, V37, P466, DOI 10.1161/ATVBAHA.116.308749
   Enerbäck S, 2009, NEW ENGL J MED, V360, P2021, DOI 10.1056/NEJMcibr0809610
   Fernández-Alfonso MS, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/402053
   Fisher FM, 2012, GENE DEV, V26, P271, DOI 10.1101/gad.177857.111
   Fontaine KR, 2003, JAMA-J AM MED ASSOC, V289, P187, DOI 10.1001/jama.289.2.187
   Friederich-Persson M, 2017, ARTERIOSCL THROM VAS, V37, P455, DOI 10.1161/ATVBAHA.116.308659
   Friedman JM, 1998, NATURE, V395, P763, DOI 10.1038/27376
   Frohnert BI, 2011, OBESITY, V19, P1735, DOI 10.1038/oby.2011.115
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gao CL, 2010, MOL CELL ENDOCRINOL, V320, P25, DOI 10.1016/j.mce.2010.01.039
   Gao YJ, 2007, BRIT J PHARMACOL, V151, P323, DOI 10.1038/sj.bjp.0707228
   Gao YJ, 2005, J THORAC CARDIOV SUR, V130, P1130, DOI 10.1016/j.jtcvs.2005.05.028
   Gao YJ, 2006, CARDIOVASC RES, V71, P363, DOI 10.1016/j.cardiores.2006.03.013
   GBDO AA, 2017, N Engl J Med, V377, P13, DOI [DOI 10.1056/NEJMOA1614362, 10.1056/NEJMoa1614362]
   Genoux A, 2020, ANN BIOL CLIN-PARIS, V78, P253, DOI 10.1684/abc.2020.1548
   Gil-Ortega M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0095312
   Gil-Ortega M, 2010, ENDOCRINOLOGY, V151, P3299, DOI 10.1210/en.2009-1464
   Gollasch M, 2004, TRENDS PHARMACOL SCI, V25, P647, DOI 10.1016/j.tips.2004.10.005
   Greenstein AS, 2009, CIRCULATION, V119, P1661, DOI 10.1161/CIRCULATIONAHA.108.821181
   Han CY, 2016, DIABETES METAB J, V40, P272
   Han CY, 2012, J BIOL CHEM, V287, P10379, DOI 10.1074/jbc.M111.304998
   Han F, 2018, CLIN EXP PHARMACOL P, V45, P50, DOI 10.1111/1440-1681.12851
   Han YH, 2016, DIABETES, V65, P2639, DOI 10.2337/db16-0283
   Hardeland R, 2012, J PINEAL RES, V52, P139, DOI 10.1111/j.1600-079X.2011.00934.x
   Harms M, 2013, NAT MED, V19, P1252, DOI 10.1038/nm.3361
   Hashimoto M, 1998, INT J OBESITY, V22, P477, DOI 10.1038/sj.ijo.0800620
   Hauck AK, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9121210
   Hauck AK, 2019, J BIOL CHEM, V294, P1083, DOI 10.1074/jbc.R118.003214
   Hauck AK, 2018, J BIOL CHEM, V293, P13464, DOI 10.1074/jbc.RA118.003469
   Hildebrand S, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00070
   Hoshino S, 2020, FEBS OPEN BIO, V10, P306, DOI 10.1002/2211-5463.12795
   Hosick PA, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18030611
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Huh JY, 2012, ANTIOXID REDOX SIGN, V16, P229, DOI [10.1089/ars.2011.3952, 10.1089/ars.2010.3766]
   Inoguchi T, 2000, DIABETES, V49, P1939, DOI 10.2337/diabetes.49.11.1939
   Jiménez-Aranda A, 2013, J PINEAL RES, V55, P416, DOI 10.1111/jpi.12089
   Kaidar-Person O, 2008, OBES SURG, V18, P1028, DOI 10.1007/s11695-007-9350-5
   Kaidar-Person O, 2008, OBES SURG, V18, P870, DOI 10.1007/s11695-007-9349-y
   Ketonen J, 2010, CIRC J, V74, P1479, DOI 10.1253/circj.CJ-09-0661
   Kim HR, 2020, ACTA DIABETOL, V57, P151, DOI 10.1007/s00592-019-01388-5
   Kim MH, 2020, CELL BIOL INT, V44, P2086, DOI 10.1002/cbin.11417
   King AL, 2014, P NATL ACAD SCI USA, V111, P3182, DOI 10.1073/pnas.1321871111
   Klisic A, 2020, EAT WEIGHT DISORD-ST, V25, P9, DOI 10.1007/s40519-018-0490-5
   Knudson JD, 2005, AM J PHYSIOL-HEART C, V289, pH48, DOI 10.1152/ajpheart.01159.2004
   Kobayashi M, 2019, BIOCHEM BIOPH RES CO, V508, P117, DOI 10.1016/j.bbrc.2018.11.127
   Korda M, 2008, AM J PHYSIOL-HEART C, V295, pH1514, DOI 10.1152/ajpheart.00479.2008
   Kumar RK, 2019, PHARMACOL RES, V140, P43, DOI 10.1016/j.phrs.2018.08.024
   Le Lay S, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/908539
   Leandro A, 2021, FREE RADICAL BIO MED, V162, P233, DOI 10.1016/j.freeradbiomed.2020.10.021
   Lee H, 2009, J BIOL CHEM, V284, P10601, DOI 10.1074/jbc.M808742200
   Lee YC, 2011, CIRCULATION, V124, P1160, DOI 10.1161/CIRCULATIONAHA.111.027375
   Leitner BP, 2017, P NATL ACAD SCI USA, V114, P8649, DOI 10.1073/pnas.1705287114
   Li HG, 2013, TRENDS PHARMACOL SCI, V34, P313, DOI 10.1016/j.tips.2013.03.007
   Li RM, 2017, METAB SYNDR RELAT D, V15, P450, DOI 10.1089/met.2017.0074
   Lin Y, 2005, J BIOL CHEM, V280, P4617, DOI 10.1074/jbc.M411863200
   Loh K, 2009, CELL METAB, V10, P260, DOI 10.1016/j.cmet.2009.08.009
   Long EK, 2013, FREE RADICAL BIO MED, V63, P390, DOI 10.1016/j.freeradbiomed.2013.05.030
   Luo X, 2012, DIABETES, V61, P124, DOI 10.2337/db11-0998
   Ma LQ, 2010, HYPERTENS RES, V33, P446, DOI 10.1038/hr.2010.11
   Mai Y, 2014, BIOCHEM CELL BIOL, V92, P172, DOI 10.1139/bcb-2014-0011
   Man AWC, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9070574
   Manna P, 2015, METAB SYNDR RELAT D, V13, P423, DOI 10.1089/met.2015.0095
   Margaritis M, 2013, CIRCULATION, V127, P2209, DOI 10.1161/CIRCULATIONAHA.112.001133
   Merry TL, 2016, DIABETOLOGIA, V59, P2632, DOI 10.1007/s00125-016-4084-3
   Mueller CFH, 2005, ARTERIOSCL THROM VAS, V25, P274, DOI 10.1161/01.ATV.0000149143.04821.eb
   Nakamura K, 2014, J CARDIOL, V63, P250, DOI 10.1016/j.jjcc.2013.11.006
   Neves KB, 2014, CLIN SCI, V127, P111, DOI 10.1042/CS20130286
   Nguyen T, 2009, J BIOL CHEM, V284, P13291, DOI 10.1074/jbc.R900010200
   Oikonomou EK, 2019, NAT REV CARDIOL, V16, P83, DOI 10.1038/s41569-018-0097-6
   Oikonomou EK, 2018, ANTIOXID REDOX SIGN, V29, P313, DOI 10.1089/ars.2017.7017
   Okuno Y, 2018, DIABETES, V67, P1113, DOI 10.2337/db17-1032
   Onichtchouk D, 1999, NATURE, V401, P480, DOI 10.1038/46794
   Ouchi N, 2012, CIRCULATION, V125, P3066, DOI 10.1161/CIRCULATIONAHA.112.114181
   Paglialunga S, 2015, DIABETOLOGIA, V58, P1071, DOI 10.1007/s00125-015-3531-x
   Parikh NI, 2009, OBESITY, V17, P2054, DOI 10.1038/oby.2009.60
   Parlee SD, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051072
   Patel C, 2007, J CLIN ENDOCR METAB, V92, P4476, DOI 10.1210/jc.2007-0778
   Pechanova O, 2014, INT J MOL SCI, V15, P17920, DOI 10.3390/ijms151017920
   Pepping JK, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0181500
   Peris E, 2019, J BIOL CHEM, V294, P2340, DOI 10.1074/jbc.RA118.004253
   Perkins A, 2014, BIOCHEMISTRY-US, V53, P7693, DOI 10.1021/bi5013222
   Pfeifer A, 2015, ANNU REV PHARMACOL, V55, P207, DOI 10.1146/annurev-pharmtox-010814-124346
   Piao L, 2019, ANTIOXID REDOX SIGN, V31, P1339, DOI 10.1089/ars.2018.7614
   Piché ME, 2020, CIRC RES, V126, P1477, DOI 10.1161/CIRCRESAHA.120.316101
   Picoli CD, 2020, J APPL PHYSIOL, V129, P66, DOI 10.1152/japplphysiol.00742.2019
   Pou KM, 2007, CIRCULATION, V116, P1234, DOI 10.1161/CIRCULATIONAHA.107.710509
   Procopio C, 2009, ENDOCRINOLOGY, V150, P3584, DOI 10.1210/en.2008-0921
   Prunet-Marcassus B, 2003, ENDOCRINOLOGY, V144, P5347, DOI 10.1210/en.2003-0693
   Rahmouni K, 2007, HYPERTENSION, V49, P647, DOI 10.1161/01.HYP.0000254827.59792.b2
   Reitman A, 2002, ISRAEL MED ASSOC J, V4, P590
   Rudich A, 1998, DIABETES, V47, P1562, DOI 10.2337/diabetes.47.10.1562
   Rutkowski JM, 2015, J CELL BIOL, V208, P501, DOI 10.1083/jcb.201409063
   Saito M, 2009, DIABETES, V58, P1526, DOI 10.2337/db09-0530
   Sakurai T, 2009, BIOCHEM BIOPH RES CO, V379, P605, DOI 10.1016/j.bbrc.2008.12.127
   Salgado-Somoza A, 2010, AM J PHYSIOL-HEART C, V299, pH202, DOI 10.1152/ajpheart.00120.2010
   Schulz TJ, 2013, NATURE, V495, P379, DOI 10.1038/nature11943
   Sena CM, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01668
   Shin SK, 2020, REDOX BIOL, V37, DOI 10.1016/j.redox.2020.101749
   Sies H, 2017, REDOX BIOL, V11, P613, DOI 10.1016/j.redox.2016.12.035
   Skalicky J, 2008, CLIN CHEM LAB MED, V46, P499, DOI 10.1515/CCLM.2008.096
   Stanford KI, 2013, J CLIN INVEST, V123, P215, DOI 10.1172/JCI62308
   Strissel KJ, 2007, DIABETES, V56, P2910, DOI 10.2337/db07-0767
   Sun XD, 2020, ANTIOXID REDOX SIGN, V32, P173, DOI 10.1089/ars.2019.7769
   Szasz T, 2012, CLIN SCI, V122, P1, DOI 10.1042/CS20110151
   Takaoka M, 2010, ARTERIOSCL THROM VAS, V30, P1576, DOI 10.1161/ATVBAHA.110.207175
   Tan DX, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17122124
   Taubes G, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f1050
   Thomou T, 2017, NATURE, V542, P450, DOI 10.1038/nature21365
   Tsushima Y, 2013, J BIOL CHEM, V288, P27138, DOI 10.1074/jbc.M113.485094
   Vaziri ND, 2006, NAT CLIN PRACT NEPHR, V2, P582, DOI 10.1038/ncpneph0283
   Villarroya F, 2017, NAT REV ENDOCRINOL, V13, P26, DOI 10.1038/nrendo.2016.136
   Wajchenberg BL, 2000, ENDOCR REV, V21, P697, DOI 10.1210/er.21.6.697
   Watts SW, 2013, ARTERIOSCL THROM VAS, V33, P1320, DOI 10.1161/ATVBAHA.113.301476
   WHO, 2017, NONCOMMUNICABLE DIS
   Wolden-Hanson T, 2000, ENDOCRINOLOGY, V141, P487, DOI 10.1210/en.141.2.487
   Wonisch W, 2012, AGING MALE, V15, P159, DOI 10.3109/13685538.2012.669436
   Woo KS, 2004, INT J OBESITY, V28, P852, DOI 10.1038/sj.ijo.0802539
   Wood ZA, 2003, TRENDS BIOCHEM SCI, V28, P32, DOI 10.1016/S0968-0004(02)00003-8
   Xia N, 2016, ARTERIOSCL THROM VAS, V36, P78, DOI 10.1161/ATVBAHA.115.306263
   Xie ZL, 2018, J AM HEART ASSOC, V7, DOI 10.1161/JAHA.117.007442
   Yamagishi SI, 2001, J BIOL CHEM, V276, P25096, DOI 10.1074/jbc.M007383200
NR 160
TC 55
Z9 56
U1 1
U2 19
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD MAR 4
PY 2021
VL 8
AR 650214
DI 10.3389/fcvm.2021.650214
PG 14
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA QY0RC
UT WOS:000629751600001
PM 33748199
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mrowietz, U
   Lauffer, F
   Sondermann, W
   Gerdes, S
   Sewerin, P
AF Mrowietz, Ulrich
   Lauffer, Felix
   Sondermann, Wiebke
   Gerdes, Sascha
   Sewerin, Philipp
TI Psoriasis as a Systemic Disease
SO DEUTSCHES ARZTEBLATT INTERNATIONAL
LA English
DT Review
ID ARTHRITIS; RISK
AB Background: Psoriasis was long regarded as an inflammatory disease limited to the skin. Data from dermatologic, rheumatologic and cardiologic research now show it to be a systemic disease, for which the term psoriatic disease is used. Methods: This paper is based on a selective literature search with special attention to the findings of clinical trials and other current publications, as well as the recommendations of international guidelines. Results: Immunologically mediated inflammation of the skin, arteries, bones, and joints is a central feature of psoriatic disease. Other diseases that are known to be associated with psoriatic disease include hypertension, metabolic syndrome, and depression. The main risk factor for the development of psoriatic disease is obesity, which also increases the likelihood of psoriatic arthritis. The main known trigger factors are stress, infection, and, less commonly, medication. Psoriatic disease is characterized by complex genetics and by a characteristic pattern of inflammation that involves elements of both innate and acquired immunity and, in particular, the cytokines interleukin 17 and 23. The inflammatory processes underlying psoriatic disease can now be targeted with modern biologic and other therapies. Conclusion: In view of the complexity of psoriatic disease, structured management is now recommended so that physicians and patients can work together to determine the optimal treatment strategy.
C1 [Mrowietz, Ulrich; Gerdes, Sascha] Univ Med Ctr Schleswig Holstein, Psoriasis Ctr, Dept Dermatol, Campus Kiel, Kiel, Germany.
   [Lauffer, Felix] Tech Univ Munich, Dept Dermatol & Allergol, Munich, Germany.
   [Sondermann, Wiebke] Univ Hosp Essen, Univ Duisburg Essen, Dept Dermatol, Venereol,Allergol, Essen, Germany.
   [Sewerin, Philipp] Ruhr Univ Bochum, Rheumatol Ctr Ruhr Area, Herne, Germany.
C3 University of Kiel; Schleswig Holstein University Hospital; Technical
   University of Munich; University of Duisburg Essen; Ruhr University
   Bochum
RP Mrowietz, U (corresponding author), Univ Klinikum Schleswig Holstein, Psoriasis Zentrum Zentrum Entzundl Hauterkrankunge, Klin Dermatol Venerol & Allergol, Campus Kiel Arnold Heller Str 3,Haus U27, D-24105 Kiel, Germany.
EM umrowietz@dermatology.uni-kiel.de
RI Sewerin, Philipp/AAG-7717-2020; Gerdes, Sascha/J-4308-2017; Sondermann,
   Wiebke/ACA-9208-2022; mrowietz, ulrich/B-1645-2010
OI mrowietz, ulrich/0000-0002-9539-0712; Mohammed, Shan/0009-0001-8046-1653
FU Novartis; Galapagos; MorphoSys; Almirall; Bristol-Myers-Squibb; AbbVie;
   Lilly; Janssen; Amgen
FX FL has received financial support from Novartis, Galapagos, MorphoSys,
   Almirall, Bristol-Myers-Squibb, AbbVie, Lilly, Janssen, and Amgen. He
   has received honoraria for lectures, presentations, manuscript
   preparation, and continuing medical education events from AbbVie,
   Novartis, LEO Pharma, Lilly, Almirall, Janssen, Amgen, UCB,
   Bristol-Myers-Squibb, and Biogen. He has received reimbursement of
   travel expenses and meeting participation fees from Janssen and UCB. He
   serves on the advisory boards of AbbVie, Novartis, LEO Pharma, Lilly,
   Almirall, Janssen, Amgen, UCB, Bristol-Myers-Squibb, and Union
   Therapeutics.
CR Felquer MLA, 2022, ANN RHEUM DIS, V81, P74, DOI 10.1136/annrheumdis-2021-220865
   Augustin M, 2010, BRIT J DERMATOL, V162, P633, DOI 10.1111/j.1365-2133.2009.09593.x
   Bellinato F, 2022, J ENDOCRINOL INVEST, V45, P1277, DOI 10.1007/s40618-022-01755-0
   Cheuk S, 2014, J IMMUNOL, V192, P3111, DOI 10.4049/jimmunol.1302313
   Coates LC, 2022, NAT REV RHEUMATOL, V18, P465, DOI 10.1038/s41584-022-00798-0
   Davis GK, 2021, CURR HYPERTENS REP, V23, DOI 10.1007/s11906-021-01128-7
   Egeberg A, 2017, JAMA SURG, V152, P344, DOI 10.1001/jamasurg.2016.4610
   Elnabawi YA, 2019, JAMA CARDIOL, V4, P885, DOI 10.1001/jamacardio.2019.2589
   Gelfand JM, 2006, JAMA-J AM MED ASSOC, V296, P1735, DOI 10.1001/jama.296.14.1735
   Girolimetto N, 2021, J CLIN MED, V10, DOI 10.3390/jcm10122604
   Gottlieb AB, 2021, J AM ACAD DERMATOL, V84, P92, DOI 10.1016/j.jaad.2020.05.089
   Griffiths CEM, 2021, LANCET, V397, P1301, DOI 10.1016/S0140-6736(20)32549-6
   Hagenström K, 2024, J DTSCH DERMATOL GES, V22, P45, DOI [10.1111/ddg.15269, 10.1111/ddg.15269_g]
   HENSELER T, 1995, J AM ACAD DERMATOL, V32, P982, DOI 10.1016/0190-9622(95)91336-X
   Kim J, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.1005115
   Kimball AB, 2010, J EUR ACAD DERMATOL, V24, P989, DOI 10.1111/j.1468-3083.2010.03705.x
   Kocaaga A, 2022, GLOB MED GENET, V09, P82, DOI 10.1055/s-0042-1743259
   Kuiper JJ, 2023, ANN RHEUM DIS, V82, P887, DOI 10.1136/ard-2022-222852
   Langley RG, 2021, J AM ACAD DERMATOL, V84, P60, DOI 10.1016/j.jaad.2020.08.032
   Maglio C, 2017, OBESITY, V25, P2068, DOI 10.1002/oby.21955
   Malavazos AE, 2023, ENDOCR DIAB MET C R, V2023, DOI 10.1530/EDM-23-0017
   Mrowietz U, 2023, J EUR ACAD DERMATOL, DOI 10.1111/jdv.19192
   Mrowietz U, 2021, J EUR ACAD DERMATOL, V35, P2027, DOI 10.1111/jdv.17434
   Mrowietz U, 2014, EXP DERMATOL, V23, P705, DOI 10.1111/exd.12437
   Najarian DJ, 2003, J AM ACAD DERMATOL, V48, P805, DOI 10.1067/mjd.2003.540
   Nast A, 2021, J Dtsch Dermatol Ges, V19, P934, DOI [10.1111/ddg.14508g, DOI 10.1111/DDG.14508G]
   Patrick MT, 2022, NAT COMMUN, V13, DOI 10.1038/s41467-022-34323-4
   Prinz I, 2020, J EXP MED, V217, DOI 10.1084/jem.20191397
   Puig L, 2022, BRIT J DERMATOL, V186, P773, DOI 10.1111/bjd.20963
   Schäkel K, 2023, J EUR ACAD DERMATOL, V37, P2016, DOI 10.1111/jdv.19236
   Schett G, 2022, NAT REV RHEUMATOL, V18, P311, DOI 10.1038/s41584-022-00776-6
   Sivasami P, 2023, IMMUNITY, V56, P1844, DOI 10.1016/j.immuni.2023.06.021
   Sommer R, 2020, J EUR ACAD DERMATOL, V34, P2846, DOI 10.1111/jdv.16436
   van de Kerkhof PCM, 2015, J EUR ACAD DERMATOL, V29, P2002, DOI 10.1111/jdv.13150
   Vata D, 2023, LIFE-BASEL, V13, DOI 10.3390/life13101947
   von Stebut E, 2019, J INVEST DERMATOL, V139, P1054, DOI 10.1016/j.jid.2018.10.042
   Wittenberg GM, 2020, MOL PSYCHIATR, V25, P1275, DOI 10.1038/s41380-019-0471-8
   Yee D, 2023, J AM ACAD DERMATOL, V89, P920, DOI 10.1016/j.jaad.2023.03.039
   Zabotti A, 2023, ANN RHEUM DIS, V82, P1162, DOI 10.1136/ard-2023-224148
   Zhou WN, 2020, J AM HEART ASSOC, V9, DOI 10.1161/JAHA.119.017417
NR 40
TC 8
Z9 8
U1 1
U2 2
PU DEUTSCHER AERZTE-VERLAG GMBH
PI COLOGNE
PA DIESELSTRABE 2, POSTFACH 400265, D-50859 COLOGNE, GERMANY
SN 1866-0452
J9 DTSCH ARZTEBL INT
JI Dtsch. Arztebl. Int.
PD JUL 12
PY 2024
VL 121
IS 14
DI 10.3238/arztebl.m2024.0064
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA I4H7U
UT WOS:001329890800007
PM 38657176
DA 2025-06-11
ER

PT J
AU Ahmad, P
   Shah, ARN
   Waiz, M
   Chaturvedi, CP
   Alvi, SS
   Khan, MS
AF Ahmad, Parvej
   Shah, Arunim
   Waiz, Mohd
   Chaturvedi, Chandra P.
   Alvi, Sahir Sultan
   Khan, M. Salman
TI Organosulfur Compounds, S-Allyl-L-Cysteine and
   S-Ethyl-L-Cysteine, Target PCSK-9/LDL-R-Axis to Ameliorate
   Cardiovascular, Hepatic, and Metabolic Changes in High Carbohydrate and
   High Fat Diet-Induced Metabolic Syndrome in Rats
SO PHYTOTHERAPY RESEARCH
LA English
DT Article; Early Access
DE high carbohydrate high fat (HCHF)-diet; inflammation; metabolic
   syndrome; organosulfur compounds (OSCs); PCSK-9-LDL-R axis;
   S-Allyl-L-Cysteine and S-Ethyl-L-Cysteine
ID OXIDATIVE-STRESS; IN-VITRO; EXTRACT; LYCOPENE; PCSK-9; ASSAY;
   HYPERTRIGLYCERIDEMIA; ACTIVATION; EXPRESSION; EFFICACY
AB Metabolic syndrome (MetS) is an ever-evolving set of diseases that poses a serious health risk in many countries worldwide. Existing evidence illustrates that individuals with MetS have a 30%-40% higher chance of acquiring type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), or both. This study was undertaken to uncover the regulatory role of natural organosulfur compounds (OSCs), S-allyl-L-cysteine (SAC), and S-ethyl-L-cysteine (SEC), in targeting high carbohydrate high fat (HCHF)-diet-induced MetS-associated risk management. Our findings suggested that SAC and SEC ameliorated HCHF-diet-induced diabetic profiles, plasma lipid and lipoprotein level, liver function, oxidative-stress, inflammatory cytokines, and chemokines including monocyte chemoattractant protein-1 (MCP-1), lipid peroxidation, plasma proprotein convertase subtilisin/kexin type-9 (PCSK-9), and high-sensitivity C-reactive protein (hs-CRP). Moreover, the assessment of the hepatic mRNA expression of the key genes involved in cholesterol homeostasis depicted that SAC and SEC downregulated the PCSK-9 mRNA expression via targeting the expression of HNF-1 alpha, a transcriptional activator of PCSK-9. On the other hand, the LDL-receptor (LDL-R) expression was upregulated through the activation of its transcriptional regulator sterol regulatory element binding protein-2 (SREBP-2). In addition, the activity and the mRNA expression of 3-hydroxy-3-methylglutaryl coenzyme-A reductases (HMG-R) and peroxisome proliferator-activated receptors (PPARs) were also improved by the treatment of SAC and SEC. We concluded that SAC and SEC can protect against MetS via improving the lipid and lipoprotein content, glycemic indices, hepatic function, targeting the inflammatory cascades, and oxidative imbalance, regulation of the mRNA expression of PCSK-9, LDL-R, SREBP-2, HNF-1 alpha, PPARs, and inflammatory biomarkers.
C1 [Ahmad, Parvej; Waiz, Mohd; Alvi, Sahir Sultan; Khan, M. Salman] Integral Univ, Integral Informat & Res Ctr IIRC 5, Dept Biosci, Clin Biochem & Nat Prod Res Lab, Lucknow, Uttar Pradesh, India.
   [Ahmad, Parvej; Shah, Arunim; Chaturvedi, Chandra P.] Sanjay Gandhi Postgrad Inst Med Sci SGPGIMS, Stem Cell Res Ctr, Dept Hematol, Lucknow, Uttar Pradesh, India.
   [Alvi, Sahir Sultan] Univ Texas Rio Grande Valley, Sch Med, Dept Med & Oncol ISU, Mcallen, TX 78503 USA.
   [Alvi, Sahir Sultan] Univ Texas Rio Grande Valley, South Texas Ctr Excellence Canc Res, Sch Med, Mcallen, TX 78503 USA.
   [Khan, M. Salman] Era Univ, Dept Biotechnol, Lucknow, Uttar Pradesh, India.
C3 Integral University; Sanjay Gandhi Postgraduate Institute of Medical
   Sciences; University of Texas System; University of Texas Rio Grande
   Valley; University of Texas System; University of Texas Rio Grande
   Valley
RP Alvi, SS; Khan, MS (corresponding author), Integral Univ, Integral Informat & Res Ctr IIRC 5, Dept Biosci, Clin Biochem & Nat Prod Res Lab, Lucknow, Uttar Pradesh, India.; Alvi, SS (corresponding author), Univ Texas Rio Grande Valley, Sch Med, Dept Med & Oncol ISU, Mcallen, TX 78503 USA.; Alvi, SS (corresponding author), Univ Texas Rio Grande Valley, South Texas Ctr Excellence Canc Res, Sch Med, Mcallen, TX 78503 USA.; Khan, MS (corresponding author), Era Univ, Dept Biotechnol, Lucknow, Uttar Pradesh, India.
EM sahir.alvi@utrgv.edu; contactskhan@gmail.com
RI Ahmad, Parvej/AAS-7196-2020
OI Ahmad, Parvej/0000-0002-3102-4369; Alvi, Sahir
   Sultan/0000-0002-5650-748X
FU Young Scientist Award, Department of Health Research (DHR), Ministry of
   Health & Family Welfare (MoHFW), Government of India
   [R.12014/13/2019-HR]
FX This study was supported by the Young Scientist Award, Department of
   Health Research (DHR), Ministry of Health & Family Welfare (MoHFW),
   Government of India, R.12014/13/2019-HR.
CR Adouni K, 2018, J FUNCT FOODS, V47, P521, DOI 10.1016/j.jff.2018.06.006
   Ahmad P, 2024, NAT PROD RES, V38, P3924, DOI 10.1080/14786419.2023.2269465
   Ahmad P, 2022, REV BRAS FARMACOGN, V32, P962, DOI 10.1007/s43450-022-00330-1
   Ahmad P, 2021, MED CHEM RES, V30, P2184, DOI 10.1007/s00044-021-02799-2
   Ahmad P, 2019, NATURAL BIO-ACTIVE COMPOUNDS, VOL 1: PRODUCTION AND APPLICATIONS, P561, DOI 10.1007/978-981-13-7154-7_20
   Ahmad P, 2020, LIFE SCI, V254, DOI 10.1016/j.lfs.2020.117756
   Ahmad S, 2022, INT J BIOL MACROMOL, V213, P663, DOI 10.1016/j.ijbiomac.2022.05.198
   Ahmadian M, 2013, NAT MED, V19, P557, DOI 10.1038/nm.3159
   Akhter F, 2019, BIOMED RES THER, V6, P3293, DOI 10.15419/bmrat.v6i7.556
   Akhter N, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms221910519
   Alvi SS, 2017, BIOMED PHARMACOTHER, V96, P1082, DOI 10.1016/j.biopha.2017.11.116
   Alvi SS, 2017, FREE RADICAL BIO MED, V108, P394, DOI 10.1016/j.freeradbiomed.2017.04.012
   Alvi SS, 2016, NAT PROD RES, V30, P2111, DOI 10.1080/14786419.2015.1108977
   Ayub A, 1999, ARTERIOSCL THROM VAS, V19, P330, DOI 10.1161/01.ATV.19.2.330
   Babiker Amir, 2017, Sudan J Paediatr, V17, P11, DOI 10.24911/SJP.2017.2.12
   Benzie IFF, 1996, ANAL BIOCHEM, V239, P70, DOI 10.1006/abio.1996.0292
   Berger J, 2002, ANNU REV MED, V53, P409, DOI 10.1146/annurev.med.53.082901.104018
   Besseling J, 2014, ATHEROSCLEROSIS, V233, P219, DOI 10.1016/j.atherosclerosis.2013.12.020
   Castrillo A, 2004, J CLIN INVEST, V114, P1538, DOI 10.1172/JCI200423705
   Castrillo A, 2004, ANNU REV CELL DEV BI, V20, P455, DOI 10.1146/annurev.cellbio.20.012103.134432
   Chen SCC, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-04631-7
   Chiu HF, 2016, PHYTOTHER RES, V30, P380, DOI 10.1002/ptr.5537
   de Almeida-Souza CB, 2021, METAB SYNDR RELAT D, V19, P296, DOI 10.1089/met.2020.0116
   Moreira NCD, 2020, DIABETES METAB SYND, V14, P1217, DOI 10.1016/j.dsx.2020.05.043
   Duan YJ, 2012, J BIOL CHEM, V287, P23667, DOI 10.1074/jbc.M112.350181
   Duval C, 2002, TRENDS MOL MED, V8, P422, DOI 10.1016/S1471-4914(02)02385-7
   Gambaro SE, 2018, J NUTR BIOCHEM, V61, P173, DOI 10.1016/j.jnutbio.2018.08.004
   Farag MM, 2020, DUBAI MED J, V3, P76, DOI 10.1159/000506899
   Feingold KR, 2008, BIOCHEM BIOPH RES CO, V374, P341, DOI 10.1016/j.bbrc.2008.07.023
   Francis MR, 2023, INT IMMUNOPHARMACOL, V115, DOI 10.1016/j.intimp.2023.109688
   Goldstein JL, 2015, CELL, V161, P161, DOI 10.1016/j.cell.2015.01.036
   HABIG WH, 1974, J BIOL CHEM, V249, P7130
   HAFEMAN DG, 1974, J NUTR, V104, P580, DOI 10.1093/jn/104.5.580
   Hashim A, 2019, PAK J PHARM SCI, V32, P2697, DOI 10.36721/PJPS.2019.32.6.REG.2697-2708.1
   Hu FB, 2002, JAMA-J AM MED ASSOC, V288, P2569, DOI 10.1001/jama.288.20.2569
   Ibitoye OB, 2018, ARCH PHYSIOL BIOCHEM, V124, P410, DOI 10.1080/13813455.2017.1415938
   Jahan F., 2022, Pharmacol. Res. Modern Chin. Med., V5, DOI [10.1016/j.prmcm.2022.100184, DOI 10.1016/J.PRMCM.2022.100184]
   Jain MR, 2015, PHARMACOL RES PERSPE, V3, DOI 10.1002/prp2.136
   KAKKAR P, 1984, INDIAN J BIOCHEM BIO, V21, P130
   Khushtar M, 2023, INDIAN J PHARM SCI, V85, P176
   Kumari D, 2023, HELIYON, V9, DOI 10.1016/j.heliyon.2023.e22051
   Li X, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.704145
   Lingappan Krithika, 2018, Current Opinion in Toxicology, V7, P81, DOI 10.1016/j.cotox.2017.11.002
   Mohanan PP., 2016, Hypertens J, V2, P1, DOI 10.5005/jp-journals-10043-0021
   Müller TD, 2022, NAT REV DRUG DISCOV, V21, P201, DOI 10.1038/s41573-021-00337-8
   Nabi R, 2021, ARCH BIOL SCI, V73, P265, DOI 10.2298/ABS210316021N
   Nabi R, 2023, ARCH PHYSIOL BIOCHEM, V129, P831, DOI 10.1080/13813455.2021.1874996
   Nabi R, 2020, ARCH BIOCHEM BIOPHYS, V686, DOI 10.1016/j.abb.2020.108373
   Nabi R, 2019, LIFE SCI, V235, DOI 10.1016/j.lfs.2019.116823
   Nabi R, 2019, CURR DIABETES REV, V15, P213, DOI 10.2174/1573399814666180924113442
   Nabi R, 2018, INT J BIOL MACROMOL, V116, P983, DOI 10.1016/j.ijbiomac.2018.05.115
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   Pai Vikas, 2014, J Diabetes Sci Technol, V8, P132
   Panchal SK, 2011, J BIOMED BIOTECHNOL, DOI 10.1155/2011/351982
   Park JM, 2014, J GASTROEN HEPATOL, V29, P80, DOI 10.1111/jgh.12730
   Qatmosh SA, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4782-x
   Ranasinghe P, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4041-1
   RAO AV, 1975, CLIN CHEM, V21, P1523
   Roberts CK, 2006, METABOLISM, V55, P928, DOI 10.1016/j.metabol.2006.02.022
   Sai VN., 2020, Journal of Drug Delivery and Therapeutics, V10, P208, DOI DOI 10.22270/JDDT.V10I2.3941
   Sampson M, 2020, JAMA CARDIOL, V5, P540, DOI 10.1001/jamacardio.2020.0013
   Santhosha SG, 2013, FOOD BIOSCI, V3, P59, DOI 10.1016/j.fbio.2013.07.001
   Schäfer G, 2014, ANTI-CANCER AGENT ME, V14, P233, DOI 10.2174/18715206113136660370
   Rossi JLS, 2022, DIABETES-METAB RES, V38, DOI 10.1002/dmrr.3502
   SINHA AK, 1972, ANAL BIOCHEM, V47, P389, DOI 10.1016/0003-2697(72)90132-7
   Son J, 2023, EXP MOL MED, V55, P1652, DOI 10.1038/s12276-023-01043-8
   Sosale A, 2015, DIABET METAB SYND OB, V8, P189, DOI 10.2147/DMSO.S49592
   Viswanathan V, 2014, INDIAN J PHARM SCI, V76, P256
   Vona R, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8267234
   Waiz M, 2024, CLIN LAB, V70, P286, DOI 10.7754/Clin.Lab.2023.230602
   Waiz M, 2023, FREE RADICAL RES, V57, P294, DOI 10.1080/10715762.2023.2237180
   Waiz M, 2022, EXCLI J, V21, P47, DOI 10.17179/excli2021-4453
   Wang G, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/7284767
NR 73
TC 2
Z9 2
U1 4
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD 2024 SEP 3
PY 2024
DI 10.1002/ptr.8323
EA SEP 2024
PG 21
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA E6O1D
UT WOS:001304169000001
PM 39225240
OA Bronze
DA 2025-06-11
ER

PT J
AU Khan, RJ
   Gebreab, SY
   Sims, M
   Riestra, P
   Xu, RH
   Davis, SK
AF Khan, Rumana J.
   Gebreab, Samson Y.
   Sims, Mario
   Riestra, Pia
   Xu, Ruihua
   Davis, Sharon K.
TI Prevalence, associated factors and heritabilities of metabolic syndrome
   and its individual components in African Americans: the Jackson Heart
   Study
SO BMJ OPEN
LA English
DT Article
DE Metabolic Syndrome; African Americans; Heritability
ID CARDIOVASCULAR RISK; INSULIN-RESISTANCE; EUROPEAN-AMERICAN; CENTRAL
   OBESITY; SYNDROME TRAITS; PREDICTION; HOMOCYSTEINE; ADIPONECTIN;
   DEFINITION; GENETICS
AB Objective Both environmental and genetic factors play important roles in the development of metabolic syndrome (MetS). Studies about its associated factors and genetic contribution in African Americans (AA) are sparse. Our aim was to report the prevalence, associated factors and heritability estimates of MetS and its components in AA men and women.
   Participants and setting Data of this cross-sectional study come from a large community-based Jackson Heart Study (JHS). We analysed a total of 5227 participants, of whom 1636 from 281 families were part of a family study subset of JHS.
   Methods Participants were classified as having MetS according to the Adult Treatment Panel III criteria. Multiple logistic regression analysis was performed to isolate independently associated factors of MetS (n=5227). Heritability was estimated from the family study subset using variance component methods (n=1636).
   Results About 27% of men and 40% of women had MetS. For men, associated factors with having MetS were older age, lower physical activity, higher body mass index, and higher homocysteine and adiponectin levels (p<0.05 for all). For women, in addition to all these, lower education, current smoking and higher stress were also significant (p<0.05 for all). After adjusting for covariates, the heritability of MetS was 32% (p<0.001). Heritability ranged from 14 to 45% among its individual components. Relatively higher heritability was estimated for waist circumference (45%), high density lipoprotein-cholesterol (43%) and triglycerides (42%). Heritability of systolic blood pressure (BP), diastolic BP and fasting blood glucose was 16%, 15% and 14%, respectively.
   Conclusions Stress and low education were associated with having MetS in AA women, but not in men. Higher heritability estimates for lipids and waist circumference support the hypothesis of lipid metabolism playing a central role in the development of MetS and encourage additional efforts to identify the underlying susceptibility genes for this syndrome in AA.
C1 [Khan, Rumana J.; Gebreab, Samson Y.; Riestra, Pia; Xu, Ruihua; Davis, Sharon K.] NHGRI, Cardiovasc Sect, Cardiovasc & Inflammatory Dis Genom Branch, NIH, Bethesda, MD 20892 USA.
   [Sims, Mario] Univ Mississippi, Med Ctr, Dept Internal Med, Div Hypertens, Jackson, MS 39216 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Human Genome
   Research Institute (NHGRI); University of Mississippi Medical Center;
   University of Mississippi
RP Khan, RJ (corresponding author), NHGRI, Cardiovasc Sect, Cardiovasc & Inflammatory Dis Genom Branch, NIH, Bethesda, MD 20892 USA.
EM rumana.khan@nih.gov
RI Xu, Rui-Hua/AAW-4766-2021
OI Xu, Rui-Hua/0000-0001-9771-8534
FU National Institutes of Health; National Heart, Lung, and Blood Institute
   [HHSN2682013000 46C, HHSN2682013000 47C, HHSN268201300048C,
   HHSN268201300049C, HHSN268201300050C]; National Institute on Minority
   Health and Health Disparities
FX This research was supported by the Intramural Research Program of the
   National Institutes of Health. The Jackson Heart Study is supported by
   contracts HHSN2682013000 46C, HHSN2682013000 47C, HHSN268201300048C,
   HHSN268201300049C, HHSN268201300050C from the National Heart, Lung, and
   Blood Institute and the National Institute on Minority Health and Health
   Disparities.
CR Akbartabartoori M, 2004, INT J OBES LOND, V29, P236
   [Anonymous], 2011, SAS 9.3
   Barazzoni R, 2014, NUTR CLIN PRACT, V29, P215, DOI 10.1177/0884533613516168
   Bayoumi RA, 2007, OBESITY, V15, P551, DOI 10.1038/oby.2007.555
   Bellia A, 2009, NUTR METAB CARDIOVAS, V19, P455, DOI 10.1016/j.numecd.2008.11.002
   Berlin I, 2012, TOB INDUC DIS, V10, DOI 10.1186/1617-9625-10-9
   Bhargava Alok, 2003, Popul Health Metr, V1, P3, DOI 10.1186/1478-7954-1-3
   Bosy-Westphal A, 2007, INT J OBESITY, V31, P784, DOI 10.1038/sj.ijo.0803481
   Brunner EJ, 1997, DIABETOLOGIA, V40, P1341, DOI 10.1007/s001250050830
   Cankurtaran M, 2006, ARCH GERONTOL GERIAT, V42, P35, DOI 10.1016/j.archger.2005.05.004
   Carnethon MR, 2004, DIABETES CARE, V27, P2707, DOI 10.2337/diacare.27.11.2707
   Carpenter MA, 2004, AM J MED SCI, V328, P131, DOI 10.1097/00000441-200409000-00001
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   de Edelenyi FS, 2008, GENES NUTR, V3, P173, DOI 10.1007/s12263-008-0097-y
   Dubbert PM, 2005, ETHN DIS S6, V15, P56
   Duggirala R, 1997, GENET EPIDEMIOL, V14, P987, DOI 10.1002/(SICI)1098-2272(1997)14:6<987::AID-GEPI71>3.0.CO;2-G
   Esteghamati A, 2014, J CARDIOL, V64, P290, DOI 10.1016/j.jjcc.2014.02.001
   Filozof C, 2004, Obes Rev, V5, P95, DOI 10.1111/j.1467-789X.2004.00131.x
   Ford ES, 2010, J DIABETES, V2, P180, DOI 10.1111/j.1753-0407.2010.00078.x
   Freeman MS, 2002, DIABETIC MED, V19, P994, DOI 10.1046/j.1464-5491.2002.00843.x
   Go AS, 2013, CIRCULATION, V127, pE6, DOI 10.1161/CIR.0b013e31828124ad
   Groop L, 1996, DIABETES, V45, P1585, DOI 10.2337/diabetes.45.11.1585
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Hajer GR, 2007, HEART, V93, P216, DOI 10.1136/hrt.2006.093971
   Henneman P, 2008, J MED GENET, V45, P572, DOI 10.1136/jmg.2008.058388
   Iliadou A, 2005, TWIN RES HUM GENET, V8, P492, DOI 10.1375/twin.8.5.492
   Joy T, 2008, CURR DIABETES REP, V8, P141, DOI 10.1007/s11892-008-0025-y
   Juonala M, 2011, ATHEROSCLEROSIS, V217, P234, DOI 10.1016/j.atherosclerosis.2011.03.016
   Kim JY, 2013, DIABETES CARE, V36, P1547, DOI 10.2337/dc12-0223
   Kristiansson K, 2012, CIRC-CARDIOVASC GENE, V5, P242, DOI 10.1161/CIRCGENETICS.111.961482
   Lin HF, 2005, DIABETOLOGIA, V48, P2006, DOI 10.1007/s00125-005-1892-2
   LUEPKER RV, 1993, CIRCULATION, V88, P2172, DOI 10.1161/01.CIR.88.5.2172
   Luke A, 2001, INT J OBESITY, V25, P1034, DOI 10.1038/sj.ijo.0801650
   Lyssenko V, 2008, DIABETES METAB SYND, V2, P245, DOI 10.1016/j.dsx.2008.07.002
   Mackenbach JP, 2008, NEW ENGL J MED, V358, P2468, DOI 10.1056/NEJMsa0707519
   Metelskaya VA, 2012, ARCH GERONTOL GERIAT, V55, P231, DOI 10.1016/j.archger.2011.09.005
   Mokán M, 2008, DIABETES RES CLIN PR, V81, P238, DOI 10.1016/j.diabres.2008.04.002
   Monda Keri L., 2010, Endocrine Metabolic & Immune Disorders-Drug Targets, V10, P86
   Poulsen P, 2001, DIABETOLOGIA, V44, P537, DOI 10.1007/s001250051659
   Povel CM, 2011, OBES REV, V12, P952, DOI 10.1111/j.1467-789X.2011.00907.x
   Price RA, 2000, OBES RES, V8, P360, DOI 10.1038/oby.2000.43
   Sabo RT, 2012, AM J CLIN NUTR, V96, P461, DOI 10.3945/ajcn.111.025635
   Santos DM, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/314823
   Sun K, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047791
   Taylor HA, 2005, ETHNIC DIS, V15, pS4
   Taylor HA, 2005, ETHNIC DIS, V15, pS1
   van Dongen J, 2013, J LIPID RES, V54, P2914, DOI 10.1194/jlr.P041673
   Vattikuti S, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002637
   Wilson JG, 2005, ETHNIC DIS, V15, pS30
   Feng Y, 2008, OBESITY, V16, P125, DOI 10.1038/oby.2007.22
NR 51
TC 37
Z9 40
U1 0
U2 8
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2015
VL 5
IS 10
AR e008675
DI 10.1136/bmjopen-2015-008675
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CX1PH
UT WOS:000365467600068
PM 26525420
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU McCarty, MF
AF McCarty, Mark F.
TI Salsalate may have broad utility in the prevention and treatment of
   vascular disorders and the metabolic syndrome
SO MEDICAL HYPOTHESES
LA English
DT Article
ID NF-KAPPA-B; INDUCED INSULIN-RESISTANCE; ABDOMINAL AORTIC-ANEURYSMS;
   NONACETYLATED SALICYLATE; OXIDATIVE STRESS; PYRROLIDINE DITHIOCARBAMATE;
   DIABETIC-RETINOPATHY; ATRIAL-FIBRILLATION; SODIUM-SALICYLATE; NAD(P)H
   OXIDASE
AB In the high proportion of vascular disorders associated with excessive oxidative stress and production of pro-inflammatory cytokines, activation of NF-kappaB plays a key pathogenic role. Thus, there is considerable evidence that NF-kappaB is a mediator of atherogenesis, plaque destabilization, ischemia-reperfusion damage, cardiac remodeling, atrial fibrillation, and aneurysm formation and rupture; some studies suggest that it may also play a role in the microvascular complications of diabetes. IkappaB kinase-beta (IKKbeta) is the upstream kinase that appears to be primarily responsible for NF-kappaB activation in these disorders; moreover, chronic IKKbeta activation plays a prominent role in induction of insulin resistance in the metabolic syndrome. Salicylate inhibits IKKbeta in concentrations that are achievable with dose schedules traditionally used in treating rheumatoid arthritis (3-4.5 g daily); indeed, this is likely to be the mechanism responsible for salicylate's utility in this disorder. Salicylate, unlike aspirin, is only a very weak, reversible inhibitor of cyclooxygenase in clinical doses, and thus is not associated with the potentially dangerous side effects seen with NSAIDs; fully reversible ototoxicity, the dose-limiting side effect in salicylate therapy, can be avoided in most patients by dosage adjustment. Hence, it is proposed that salicylate may have practical utility in the prevention or management of a wide range of vascular disorders as well as of metabolic syndrome and diabetes; its efficacy in these regards would likely be complemented by effective antioxidant measures, which would lessen the stimulus to NF-kappaB activation while providing benefits independent of NF-kappaB activity. Salsalate, consisting of two salicylate molecules united by an ester bond, is a venerable drug that may be the best tolerated delivery vehicle for salicylate. Appropriate rodent studies should pave the way for clinical trials with salsalate in patients at vascular risk. (C) 2010 Elsevier Ltd. All rights reserved.
C1 NutriGuard Res, San Diego, CA 92024 USA.
RP McCarty, MF (corresponding author), NutriGuard Res, 1051 Hermes Ave,811 B Nahant Ct, San Diego, CA 92024 USA.
EM mccarty@pantox.com
CR Adam O, 2007, J AM COLL CARDIOL, V50, P359, DOI 10.1016/j.jacc.2007.03.041
   [Anonymous], 1991, OPHTHALMOLOGY, V98, P757
   Aoki T, 2007, CIRCULATION, V116, P2830, DOI 10.1161/CIRCULATIONAHA.107.728303
   Aoki T, 2009, ARTERIOSCL THROM VAS, V29, P1080, DOI 10.1161/ATVBAHA.108.180760
   ATKINSON MH, 1995, CLIN THER, V17, P827, DOI 10.1016/0149-2918(95)80061-1
   BAUDOIN C, 1989, DIABETES, V38, P491
   BOMBARDIER C, 1995, J RHEUMATOL, V22, P617
   Bond M, 1999, BIOCHEM BIOPH RES CO, V264, P561, DOI 10.1006/bbrc.1999.1551
   Bond M, 1998, FEBS LETT, V435, P29, DOI 10.1016/S0014-5793(98)01034-5
   Bondeson J, 1999, J IMMUNOL, V162, P2939
   Bonizzi G, 2004, EMBO J, V23, P4202, DOI 10.1038/sj.emboj.7600391
   BRIEN JA, 1993, DRUG SAFETY, V9, P143, DOI 10.2165/00002018-199309020-00006
   Cai DS, 2005, NAT MED, V11, P183, DOI 10.1038/nm1166
   Calzado MA, 2007, CURR MED CHEM, V14, P367, DOI 10.2174/092986707779941113
   Cameron NE, 2008, CURR DRUG TARGETS, V9, P60, DOI 10.2174/138945008783431718
   Carroll W W, 1972, Ann Ophthalmol, V4, P1019
   Chase AJ, 2002, ARTERIOSCL THROM VAS, V22, P765, DOI 10.1161/01.ATV.0000015078.09208.92
   Chen F, 2005, INT J MOL MED, V15, P57
   Chen LF, 2001, SCIENCE, V293, P1653, DOI 10.1126/science.1062374
   Chen M, 2007, AM J PHYSIOL-CELL PH, V292, pC1493, DOI 10.1152/ajpcell.00016.2006
   Chiarugi A, 2003, J NEUROCHEM, V85, P306, DOI 10.1046/j.1471-4159.2003.01684.x
   de Alvaro C, 2004, J BIOL CHEM, V279, P17070, DOI 10.1074/jbc.M312021200
   de Winther MPJ, 2005, ARTERIOSCL THROM VAS, V25, P904, DOI 10.1161/01.ATV.0000160340.72641.87
   Ding Helin, 2002, Zhonghua Nei Ke Za Zhi, V41, P605
   DROMGOOLE SH, 1984, J PHARM SCI, V73, P1657, DOI 10.1002/jps.2600731147
   Dudley S, 2009, ANTIOXID REDOX SIGNA
   Dudley SC, 2005, CIRCULATION, V112, P1266, DOI 10.1161/CIRCULATIONAHA.105.538108
   Ferreira V, 2007, ATHEROSCLEROSIS, V192, P283, DOI 10.1016/j.atherosclerosis.2006.07.018
   Fleischman A, 2008, DIABETES CARE, V31, P289, DOI 10.2337/dc07-1338
   Frantz S, 2003, CARDIOVASC RES, V57, P749, DOI 10.1016/S0008-6363(02)00723-X
   Frantz S, 2006, FASEB J, V20, P1918, DOI 10.1096/fj.05-5133fje
   Freund C, 2005, CIRCULATION, V111, P2319, DOI 10.1161/01.CIR.0000164237.58200.5A
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gao ZG, 2002, J BIOL CHEM, V277, P48115, DOI 10.1074/jbc.M209459200
   Gareus R, 2008, CELL METAB, V8, P372, DOI 10.1016/j.cmet.2008.08.016
   Ghosh A, 2007, P NATL ACAD SCI USA, V104, P18754, DOI 10.1073/pnas.0704908104
   Goldfine AB, 2008, CTS-CLIN TRANSL SCI, V1, P36, DOI 10.1111/j.1752-8062.2008.00026.x
   Gong N, 2008, NEUROPHARMACOLOGY, V54, P454, DOI 10.1016/j.neuropharm.2007.10.017
   Guitton MJ, 2003, J NEUROSCI, V23, P3944
   Gupta S, 2005, AM J PHYSIOL-HEART C, V289, pH20, DOI 10.1152/ajpheart.00082.2005
   Hajra L, 2000, P NATL ACAD SCI USA, V97, P9052, DOI 10.1073/pnas.97.16.9052
   Hilder TL, 2003, FEBS LETT, V553, P63, DOI 10.1016/S0014-5793(03)00972-4
   Hotamisligil GS, 1996, SCIENCE, V271, P665, DOI 10.1126/science.271.5249.665
   Inoguchi T, 2000, DIABETES, V49, P1939, DOI 10.2337/diabetes.49.11.1939
   Inoguchi T, 2005, CURR DRUG TARGETS, V6, P495, DOI 10.2174/1389450054021927
   Inoguchi T, 2007, JAMA-J AM MED ASSOC, V298, P1398, DOI 10.1001/jama.298.12.1398-b
   Irwin C, 2008, J VASC SURG, V48, P1278, DOI 10.1016/j.jvs.2008.06.056
   Iwamoto M, 2005, TOHOKU J EXP MED, V206, P163, DOI 10.1620/tjem.206.163
   Jawien J, 2005, J PHYSIOL PHARMACOL, V56, P483
   Kabashima K, 2004, FEBS LETT, V578, P36, DOI 10.1016/j.febslet.2004.10.065
   Kabay B, 2007, WORLD J SURG, V31, P1707, DOI 10.1007/s00268-007-9112-5
   Kang JL, 2006, TOXICOL SCI, V90, P470, DOI 10.1093/toxsci/kfj096
   Kanters E, 2003, J CLIN INVEST, V112, P1176, DOI 10.1172/JCI18580
   Karin M, 2000, SEMIN IMMUNOL, V12, P85, DOI 10.1006/smim.2000.0210
   Kim DS, 2006, CANCER RES, V66, P10936, DOI 10.1158/0008-5472.CAN-06-1521
   Kim HS, 2007, EXP MOL MED, V39, P106, DOI 10.1038/emm.2007.12
   Kim JK, 2001, J CLIN INVEST, V108, P437, DOI 10.1172/JCI11559
   Kim YM, 2005, CIRC RES, V97, P629, DOI 10.1161/01.RES.0000183735.09871.61
   KOPP E, 1994, SCIENCE, V265, P956, DOI 10.1126/science.8052854
   Koska J, 2009, DIABETOLOGIA, V52, P385, DOI 10.1007/s00125-008-1239-x
   Kouba DJ, 1999, J IMMUNOL, V162, P4226
   Kuang PP, 2002, AM J PHYSIOL-CELL PH, V283, pC58, DOI 10.1152/ajpcell.00314.2001
   Kutuk O, 2003, TRENDS MOL MED, V9, P549, DOI 10.1016/j.molmed.2003.10.007
   Lee JM, 2004, J BIOL CHEM, V279, P53725, DOI 10.1074/jbc.M407627200
   Lu YG, 2009, BR J PHARM
   Mahabeleshwar GH, 2003, J BIOL CHEM, V278, P52598, DOI 10.1074/jbc.M308941200
   McCarty M.F., 2009, Med Hypotheses
   McCarty MF, 2007, J MED FOOD, V10, P566, DOI 10.1089/jmf.2007.621
   McCarty MF, 2010, MED HYPOTHE IN PRESS
   McCarty MF, 2008, NUTRACEUTICALS GLYCE
   Miyake T, 2006, GENE THER, V13, P695, DOI 10.1038/sj.gt.3302704
   Miyake T, 2007, CIRC RES, V101, P1175, DOI 10.1161/CIRCRESAHA.107.148668
   Monaco C, 2004, P NATL ACAD SCI USA, V101, P5634, DOI 10.1073/pnas.0401060101
   Monaco C, 2004, CARDIOVASC RES, V61, P671, DOI 10.1016/j.cardiores.2003.11.038
   MORRIS HG, 1985, THER DRUG MONIT, V7, P435, DOI 10.1097/00007691-198512000-00012
   Najbauer J, 2000, NEUROSCIENCE, V99, P107, DOI 10.1016/S0306-4522(00)00158-5
   Newby AC, 2008, ARTERIOSCL THROM VAS, V28, P2108, DOI 10.1161/ATVBAHA.108.173898
   Nichols TC, 2004, DRUG NEWS PERSPECT, V17, P99, DOI 10.1358/dnp.2004.17.2.829042
   Onai Y, 2007, AM J PHYSIOL-HEART C, V292, pH530, DOI 10.1152/ajpheart.00549.2006
   Park CW, 2000, DIABETOLOGIA, V43, P1544, DOI 10.1007/s001250051567
   Park E, 2007, J ENDOCRINOL, V195, P323, DOI 10.1677/JOE-07-0005
   Parodi FE, 2005, J VASC SURG, V41, P479, DOI 10.1016/j.jvs.2004.12.030
   Pierce GL, 2009, CIRCULATION, V119, P1284, DOI 10.1161/CIRCULATIONAHA.108.804294
   POWELL EDU, 1964, LANCET, V2, P17
   Raffetto JD, 2008, J VASC SURG, V48, P447, DOI 10.1016/j.jvs.2008.03.004
   Raffetto JD, 2008, CURR VASC PHARMACOL, V6, P158, DOI 10.2174/157016108784911957
   Ritchie NE, 1998, CIRCULATION, V98, P1707, DOI 10.1161/01.CIR.98.17.1707
   ROBERT A, 1981, PROSTAGLANDINS, V21, P139, DOI 10.1016/0090-6980(81)90130-1
   Romeo G, 2002, DIABETES, V51, P2241, DOI 10.2337/diabetes.51.7.2241
   ROTH S, 1990, SEMIN ARTHRITIS RHEU, V19, P11
   Shang LL, 2008, AM J PHYSIOL-CELL PH, V294, pC372, DOI 10.1152/ajpcell.00186.2007
   SHIMOKAWA T, 1992, J BIOL CHEM, V267, P12387
   Shoelson SE, 2003, INT J OBESITY, V27, pS49, DOI 10.1038/sj.ijo.0802501
   SINGLETON PT, 1980, CLIN THER, V3, P80
   Takatsuna H, 2005, BIOMED PHARMACOTHER, V59, P318, DOI 10.1016/j.biopha.2005.01.011
   Takemoto M, 2001, J CLIN INVEST, V108, P1429, DOI 10.1172/JCI13350
   Talior I, 2005, AM J PHYSIOL-ENDOC M, V288, pE405, DOI 10.1152/ajpendo.00378.2004
   Timmers S, 2008, PHYSIOL BEHAV, V94, P242, DOI 10.1016/j.physbeh.2007.12.002
   Trescher K, 2006, CARDIOVASC RES, V69, P746, DOI 10.1016/j.cardiores.2005.11.027
   Vermeulen L, 2003, EMBO J, V22, P1313, DOI 10.1093/emboj/cdg139
   Xu MQ, 2005, WORLD J GASTROENTERO, V11, P6960, DOI 10.3748/wjg.v11.i44.6960
   Yang JYO, 2009, AM J PHYSIOL-HEART C, V296, pH1850, DOI 10.1152/ajpheart.01199.2008
   Yang WH, 2008, P NATL ACAD SCI USA, V105, P17345, DOI 10.1073/pnas.0806198105
   Yin MJ, 1998, NATURE, V396, P77, DOI 10.1038/23948
   Yoshida A, 1999, INVEST OPHTH VIS SCI, V40, pS704
   Yoshimura S, 2003, SCAND J IMMUNOL, V58, P165, DOI 10.1046/j.1365-3083.2003.01246.x
   Yuan MS, 2001, SCIENCE, V293, P1673, DOI 10.1126/science.1061620
   Zheng L, 2007, DIABETES, V56, P337, DOI 10.2337/db06-0789
   Zhou B, 2009, BMC MED GENET, V10, DOI 10.1186/1471-2350-10-47
   Ziegler Dan, 2004, Treat Endocrinol, V3, P173, DOI 10.2165/00024677-200403030-00005
   Zund G, 1998, EUR J CARDIO-THORAC, V13, P293, DOI 10.1016/S1010-7940(97)00318-7
NR 111
TC 19
Z9 20
U1 0
U2 10
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD SEP
PY 2010
VL 75
IS 3
BP 276
EP 281
DI 10.1016/j.mehy.2009.12.027
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 647IF
UT WOS:000281611100002
PM 20080359
DA 2025-06-11
ER

PT J
AU Lohse, B
   Nguyen, B
   Drees, BM
   Bailey-Davis, L
   Masters, KS
   Nicklas, JM
   Daniels, BT
   Ruder, EH
   Trabold, N
AF Lohse, Barbara
   Nguyen, Bong
   Drees, Betty M.
   Bailey-Davis, Lisa
   Masters, Kevin S.
   Nicklas, Jacinda M.
   Daniels, Bryce T.
   Ruder, Elizabeth H.
   Trabold, Nicole
TI Examination of eating competence in a geo-diverse sample with metabolic
   syndrome
SO APPETITE
LA English
DT Article
DE Eating behavior; Eating competence; Metabolic syndrome; Mindfulness;
   Quality-of-life; Waist circumference
ID BEHAVIORS; DIET; QUESTIONNAIRE; OVERWEIGHT; VALIDITY; PROGRAM; SUPPORT;
   QUALITY; IMPACT; FRUIT
AB Eating competence (EatC) is an intra-individual approach to eating attitudes and behaviors associated with greater well-being. EatC research has not included persons with confirmed metabolic syndrome (MetS). Therefore, EatC of persons with MetS was explored to identify unique associations and inform implementation of MetS lifestyle interventions using baseline data from a multisite, randomized trial of a 2-year lifestyle intervention with MetS. EatC, measured with the Satter Eating Competence Inventory 2.0 (ecSI 2.0 (TM)), was examined for relationships with bioclinical measures (e.g., blood pressure, lipids), medication use, BMI, waist circumference, fruit/vegetable intake, and psychosocial factors, (e.g., stress, mindfulness). Data were collected in person and video call by trained research personnel. EatC was examined as a continuous score and as a categorical variable with ecSI 2.0 (TM) scores >= 32 considered eating competent. Participants (n = 618) were predominantly female (76%), White (74%), college educated (60%). Mean age was 55.5 +/- 11 y. Mean ecSI 2.0 (TM) was 29.9 +/- 7.4 and 42% were eating competent. EatC was greater for males, persons who were older and food secure. Competent eaters (vs. non-eating competent) had lower waist circumference (112.7 +/- 12.5 cm vs.116.8 +/- 16.0 cm; P < 0.001) and BMI (35.0 +/- 6.1 vs. 37.5 +/- 7.3; P < 0.001). Serum triglycerides, HDL-cholesterol, fasting blood glucose, HbA1c, and blood pressure did not differ by EatC status. Compared to non-eating competent persons, competent eaters perceived less stress, were more mindful, indicated better physical function, and more habitual vegetable intake (all P < 0.001) and sensory awareness (P < 0.05). EatC in MetS paralleled the non-MetS profile. EatC was associated with a healthier psychosocial profile, waist circumference and BMI. Findings support further research to examine the mediational or moderating influence of EatC in the treatment of MetS.
C1 [Lohse, Barbara; Ruder, Elizabeth H.; Trabold, Nicole] Rochester Inst Technol, 180 Lomb Mem Dr, Rochester, NY 14623 USA.
   [Nguyen, Bong; Drees, Betty M.] Univ Missouri, Sch Med, 2411 Holmes St, Kansas City, MO 64108 USA.
   [Bailey-Davis, Lisa] Geisinger Hlth Syst, 100 N Acad Ave, Danville, PA 17822 USA.
   [Masters, Kevin S.; Nicklas, Jacinda M.] Univ Colorado Denver, 13001 E 17th Pl, Aurora, CO 80045 USA.
   [Daniels, Bryce T.] Rush Univ, Med Ctr, 1700 W Van Buren St,Suite 470, Chicago, IL 60612 USA.
   [Trabold, Nicole] Syracuse VA Med Ctr, Ctr Integrated Healthcare, Syracuse, NY 13210 USA.
C3 Rochester Institute of Technology; University of Missouri System;
   University of Missouri Kansas City; Geisinger Health System; University
   of Colorado System; University of Colorado Anschutz Medical Campus;
   Children's Hospital Colorado; Rush University; Syracuse University
RP Lohse, B (corresponding author), Rochester Inst Technol, 180 Lomb Mem Dr, Rochester, NY 14623 USA.
EM balihst@rit.edu; bong.nguyen@umkc.edu; dreesb@umkc.edu;
   ldbaileydavis@geisinger.edu; Kevin.Masters@ucdenver.edu;
   jacinda.nicklas@ucdenver.edu; Bryce_Daniels@rush.edu; ehrihst@rit.edu;
   nxtihst@rit.edu
RI Nguyen, Bong/LZH-0438-2025
FU William G. McGowan Charitable Fund; Wegmans School of Health and
   Nutrition at the Rochester Institute of Technology
FX This work was supported by a grant from the William G. McGowan
   Charitable Fund and by the Wegmans School of Health and Nutrition at the
   Rochester Institute of Technology.
CR Adler NE, 2000, HEALTH PSYCHOL, V19, P586, DOI 10.1037/0278-6133.19.6.586
   Ahern AL, 2016, BRIT J GEN PRACT, V66, pE258, DOI 10.3399/bjgp16X684337
   Aittola K, 2021, NUTRIENTS, V13, DOI 10.3390/nu13114030
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Ali R, 2002, ADDICTION, V97, P1183
   [Anonymous], 2016, National Health and Nutrition Examination Survey (NHANES), 2009-2010
   Baer RA, 2006, ASSESSMENT, V13, P27, DOI 10.1177/1073191105283504
   Baer RA, 2008, ASSESSMENT, V15, P329, DOI 10.1177/1073191107313003
   Boeira Caroline Frois, 2023, Int J Environ Res Public Health, V20, DOI 10.3390/ijerph20043488
   Castro-Barquero S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12102983
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Coleman-Jensen A., 2014, HOUSEHOLD FOOD SECUR
   Cornier MA, 2008, ENDOCR REV, V29, P777, DOI 10.1210/er.2008-0024
   Crane MM, 2020, TRIALS, V21, DOI 10.1186/s13063-020-04500-1
   de Oliveira PM, 2022, NUTRIENTS, V14, DOI 10.3390/nu14142815
   de Queiroz FLN, 2020, NUTRIENTS, V12, DOI 10.3390/nu12103218
   Economic Research Service United States Department of Agriculture, 2012, Adult food security survey module
   Evans KM, 2023, NEUROGASTROENT MOTIL, V35, DOI 10.1111/nmo.14584
   Godleski S, 2019, J NUTR EDUC BEHAV, V51, P1003, DOI 10.1016/j.jneb.2019.05.287
   Greene GW, 2012, AM J HEALTH PROMOT, V27, pE47, DOI 10.4278/ajhp.110606-QUAN-239
   Järvelä-Reijonen E, 2016, APPETITE, V103, P249, DOI 10.1016/j.appet.2016.04.023
   Krall JS, 2011, INT J BEHAV NUTR PHY, V8, DOI 10.1186/1479-5868-8-26
   Krall JS, 2015, J COMMUN HEALTH, V40, P448, DOI 10.1007/s10900-014-9955-2
   Kroenke K, 2009, J AFFECT DISORDERS, V114, P163, DOI 10.1016/j.jad.2008.06.026
   Lee KI, 2017, ASIA PAC J CLIN NUTR, V26, P175, DOI 10.6133/apjcn.052016.01
   Lohse B, 2007, J NUTR EDUC BEHAV, V39, pS154, DOI 10.1016/j.jneb.2007.04.371
   Lohse B, 2022, PREV CHRONIC DIS, V19, DOI 10.5888/pcd19.220206
   Lohse B, 2021, J NUTR EDUC BEHAV, V53, P211, DOI 10.1016/j.jneb.2020.11.007
   Lohse B, 2020, NUTRIENTS, V12, DOI 10.3390/nu12092667
   Lohse Barbara, 2019, J Dent Hyg, V93, P42
   Lohse B, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071501
   Lohse B, 2018, AM J HEALTH PROMOT, V32, P718, DOI 10.1177/0890117117692201
   Lohse B, 2015, J NUTR EDUC BEHAV, V47, P265, DOI 10.1016/j.jneb.2015.01.006
   Lohse B, 2015, APPETITE, V87, P223, DOI 10.1016/j.appet.2014.12.228
   Lohse B, 2013, BMC WOMENS HEALTH, V13, DOI 10.1186/1472-6874-13-12
   Lohse B, 2013, J NUTR EDUC BEHAV, V45, P69, DOI 10.1016/j.jneb.2012.06.006
   Lohse B, 2012, J NUTR, V142, P1903, DOI 10.3945/jn.112.164269
   Lohse B, 2012, APPETITE, V58, P645, DOI 10.1016/j.appet.2011.11.022
   Lohse B, 2010, J NUTR, V140, P1322, DOI 10.3945/jn.109.120188
   Lynch CJ, 2023, AM J CLIN NUTR, V118, P10, DOI 10.1016/j.ajcnut.2023.04.027
   Martin SS, 2013, JAMA-J AM MED ASSOC, V310, P2061, DOI 10.1001/jama.2013.280532
   Murphy S, 2021, NUTRIENTS, V13, DOI 10.3390/nu13072388
   de Queiroz FLN, 2021, FOODS, V10, DOI 10.3390/foods10092001
   National Cancer Institute Division of Cancer Control & Population Sciences, 2021, Scoring the all-day screener
   Odoms-Young A, 2024, AM J CLIN NUTR, V119, P850, DOI 10.1016/j.ajcnut.2023.12.019
   Park S., 2013, Module 5. CDCP A data user's guide to the BRFSS sugarsweetened beverage questions
   Psota TL, 2007, J NUTR EDUC BEHAV, V39, pS171, DOI 10.1016/j.jneb.2007.05.004
   Quest Diagnostics, 2023, Lipid panel, standard
   Quick V, 2016, BEHAV SLEEP MED, V14, P565, DOI 10.1080/15402002.2015.1065411
   Quick V, 2015, EAT BEHAV, V19, P15, DOI 10.1016/j.eatbeh.2015.06.012
   Rounds T, 2019, AM J MENS HEALTH, V13, DOI 10.1177/1557988319832120
   SALLIS JF, 1987, PREV MED, V16, P825, DOI 10.1016/0091-7435(87)90022-3
   Satter E., 2008, Secrets of feeding a healthy family: How to eat, how to raise good eaters, how to cook, V2nd
   Satter E, 2007, J NUTR EDUC BEHAV, V39, pS189, DOI 10.1016/j.jneb.2007.04.177
   Satter E, 2007, J NUTR EDUC BEHAV, V39, pS142, DOI 10.1016/j.jneb.2007.01.006
   Tanja TT, 2015, NUTRIENTS, V7, P3828, DOI 10.3390/nu7053828
   Thompson FE, 2000, AM J CLIN NUTR, V71, P1503
   Tilles-Tirkkonen T, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010104
   van der Valk ES, 2018, CURR OBES REP, V7, P193, DOI 10.1007/s13679-018-0306-y
   Verplanken B, 2003, J APPL SOC PSYCHOL, V33, P1313, DOI 10.1111/j.1559-1816.2003.tb01951.x
   Volpp KG, 2023, CIRCULATION, V148, P1417, DOI 10.1161/CIR.0000000000001182
   WARE JE, 1992, MED CARE, V30, P473, DOI 10.1097/00005650-199206000-00002
   Yasuzato M, 2021, JPN J NURS SCI, V18, DOI 10.1111/jjns.12393
NR 63
TC 0
Z9 0
U1 0
U2 1
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0195-6663
EI 1095-8304
J9 APPETITE
JI Appetite
PD AUG 1
PY 2024
VL 199
AR 107373
DI 10.1016/j.appet.2024.107373
EA MAY 2024
PG 12
WC Behavioral Sciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Nutrition & Dietetics
GA TQ2P5
UT WOS:001242662800001
PM 38677621
OA hybrid
DA 2025-06-11
ER

PT J
AU Bengmark, S
AF Bengmark, S
TI Acute and "chronic" phase reaction - a mother of disease
SO CLINICAL NUTRITION
LA English
DT Review
DE acute phase esponse; chronic phase response; metabolic syndrome;
   cellular membranes; endothelial cells; abdominal obesity; insulin
   resistance; growth hormones; free fatty acids; Alzheimer disease;
   Parkinson disease; neurodegenerative iseases; arteriosclerosis;
   coronary-vascular diseases; cancer; breast cancer; colorectal cancer;
   prostatic cancer; diabetes; cirrhosis; fatty liver; gallbladder disease;
   chronic renal disease; chroncic locomotor disease; gout; rheumatoid
   arthritis; Crohn's disease; ulcerative disease; inflammatory bowel
   disease; irritable bowel syndrome; polycystic ovary syndrome
ID FREE FATTY-ACID; CORONARY-HEART-DISEASE; PLASMINOGEN-ACTIVATOR
   INHIBITOR-1; INSULIN-RESISTANCE; CELL-MEMBRANE; ENDOTHELIAL DYSFUNCTION;
   HOMOCYSTEINE LEVELS; DIABETES-MELLITUS; ENERGY-METABOLISM; LIVER
   STEATOSIS
AB The world is increasingly threatened by a global epidemy of chronic diseases. Almost half of the global morbidity and almost two thirds of global mortality is due to these diseases-approximately 35 million die each year from chronic diseases. And they continue to increase. Increasing evidence suggest that these diseases are associated with lifestyle, stress, lack of physical exercise, over-consumption of calorie-condensed foods rich in saturated fat, sugar and starch, but also under-consumption of antioxidant-rich fruits and vegetables. As a result the function of the innate immune system is severe impaired. This review discusses the changes induced in response to mental and physical stress and their association with the subsequent development of metabolic syndrome, and its association with various chronic diseases. The endothelial cells and their function appears to be of great importance, and the function of their cellular membranes of special importance to the function of the underlying cells; their ability to obtain nutrients and antioxidants and to eliminate waste products. The abdominal adipocytes seen to play a key role, as they have the ability to in stressful situations release much of proinflammatory cytokines, PAI-1 and free fatty acids compared to elsewhere in the body. The load on the liver of these various substances in often of greater magnitude than the liver can handle. Some of the most common chronic diseases and their potential association with acute and "chronic" phase response, and with metabolic syndrome are discussed separately. The need for studies with lifestyle modifications is especially emphasized. (C) 2004 Elsevier Ltd. All rights reserved.
C1 UCL, Dept Surg & Liver Inst, London, England.
C3 University of London; University College London
RP UCL, Dept Surg & Liver Inst, London, England.
EM S.bengmark@ucl.ac.uk
OI Bengmark, Stig/0000-0003-1809-8889
CR Alessi MC, 1997, DIABETES, V46, P860, DOI 10.2337/diabetes.46.5.860
   Bazzano LA, 2002, STROKE, V33, P1183, DOI 10.1161/01.STR.0000014607.90464.88
   BENGMAR.S, 1969, DIGESTION, V2, P304, DOI 10.1159/000196955
   Bengmark S, 2001, NUTRITION, V17, P489, DOI 10.1016/S0899-9007(01)00581-0
   BOYLE JP, 2002, NEPHROL DIAL TRANS S, V17, pS28
   BRANDTZAEG P, 1989, GASTROENTEROLOGY, V97, P1562, DOI 10.1016/0016-5085(89)90406-X
   BROWN RE, 1983, J IMMUNOL, V131, P1011
   Bruunsgaard H, 2002, EUR CYTOKINE NETW, V13, P389
   Bruunsgaard H, 2001, CURR OPIN HEMATOL, V8, P131, DOI 10.1097/00062752-200105000-00001
   Camejo G, 2002, ATHEROSCLEROSIS SUPP, V3, P3, DOI 10.1016/S1567-5688(01)00005-8
   Camus J P, 1966, Rev Rhum Mal Osteoartic, V33, P10
   Caprari P, 1999, EXP GERONTOL, V34, P47, DOI 10.1016/S0531-5565(98)00055-2
   Capristo E, 1999, ALIMENT PHARM THERAP, V13, P209
   Cigolini M, 1996, THROMB HAEMOSTASIS, V76, P69
   Clarke R, 1998, ARCH NEUROL-CHICAGO, V55, P1449, DOI 10.1001/archneur.55.11.1449
   COOPER RA, 1977, NEW ENGL J MED, V297, P371
   Corkins MR, 2003, J PEDIATR GASTR NUTR, V36, P228, DOI 10.1097/00005176-200302000-00014
   Corry DB, 2001, CURR OPIN NEPHROL HY, V10, P507, DOI 10.1097/00041552-200107000-00005
   De Almeida IT, 2002, CLIN NUTR, V21, P219, DOI 10.1054/clnu.2001.0529
   Demir H, 1999, SCAND J RHEUMATOL, V28, P41
   Dessein PH, 2002, J RHEUMATOL, V29, P462
   Diehl AK, 2000, HEPATOLOGY, V31, P528, DOI 10.1002/hep.510310238
   Dixon JB, 2001, GASTROENTEROLOGY, V121, P91, DOI 10.1053/gast.2001.25540
   Duncan B B, 2001, Sao Paulo Med J, V119, P122
   DUNDER K, 2003, BMJ-BRIT MED J, V326, P680
   Facchini FS, 2001, J CLIN ENDOCR METAB, V86, P3574, DOI 10.1210/jc.86.8.3574
   Fliser D, 1998, KIDNEY INT, V53, P1343, DOI 10.1046/j.1523-1755.1998.00898.x
   Frame LT, 1998, ENVIRON HEALTH PERSP, V106, P313
   FRANKS S, 1995, NEW ENGL J MED, V333, P853, DOI 10.1056/NEJM199509283331307
   Fried SK, 1998, J CLIN ENDOCR METAB, V83, P847, DOI 10.1210/jc.83.3.847
   Genesca J, 1999, AM J GASTROENTEROL, V94, P169
   Giovannucci E, 2001, J NUTR, V131, p3109S, DOI 10.1093/jn/131.11.3109S
   Gonzalez F, 1999, METABOLISM, V48, P437, DOI 10.1016/S0026-0495(99)90100-2
   Hadigan C, 2002, METABOLISM, V51, P1143, DOI 10.1053/meta.2002.34704
   Hammarsten J, 2001, EUR UROL, V39, P151, DOI 10.1159/000052430
   Hammarsten J, 1998, PROSTATE CANCER P D, V1, P157, DOI 10.1038/sj.pcan.4500221
   HAUGAARD SB, 2004, UNPUB AM J PHYSL END
   Henderson ST, 2004, MED HYPOTHESES, V62, P689, DOI 10.1016/j.mehy.2003.11.028
   Hendrickson SC, 1997, MOL CELL BIOCHEM, V166, P85, DOI 10.1023/A:1006886601825
   Himsworth HP, 1936, LANCET, V1, P127
   HOLM LE, 1993, J NATL CANCER I, V85, P32, DOI 10.1093/jnci/85.1.32
   Holmes MD, 2002, CANCER EPIDEM BIOMAR, V11, P852
   Hoppu U, 2000, EUR J CLIN NUTR, V54, P702, DOI 10.1038/sj.ejcn.1601079
   Ibáñez L, 2002, PEDIATR RES, V51, P244, DOI 10.1203/00006450-200202000-00019
   IRISH A, 1998, ATHEROSCLEROSIS, V53, P1343
   JAIN M, 1994, J NATL CANCER I, V86, P1390, DOI 10.1093/jnci/86.18.1390
   KANNEL WB, 1990, AM HEART J, V120, P672, DOI 10.1016/0002-8703(90)90026-T
   Katz AM, 2002, CIRCULATION, V105, P669, DOI 10.1161/circ.105.6.669
   Kelly CJG, 2002, J CLIN ENDOCR METAB, V87, P3287, DOI 10.1210/jc.87.7.3287
   Kohler HP, 2000, NEW ENGL J MED, V342, P1792, DOI 10.1056/NEJM200006153422406
   Larsen TB, 2002, PATHOPHYSIOL HAEMO T, V32, P92, DOI 10.1159/000065082
   Lawrance IC, 2001, INFLAMM BOWEL DIS, V7, P16, DOI 10.1097/00054725-200102000-00003
   LEGASPI A, 1987, METABOLISM, V36, P958, DOI 10.1016/0026-0495(87)90132-6
   Legro RS, 2001, AM J MED, V111, P607, DOI 10.1016/S0002-9343(01)00948-2
   Legro RS, 2001, MOL CELL ENDOCRINOL, V184, P87, DOI 10.1016/S0303-7207(01)00640-2
   Lemaitre RN, 2002, CIRCULATION, V105, P697, DOI 10.1161/hc0602.103583
   Lind L, 1994, Clin Intensive Care, V5, P100
   Liu L, 2002, CLIN CARDIOL, V25, P219, DOI 10.1002/clc.4950250505
   Liuba P, 2000, CIRCULATION, V102, P1039, DOI 10.1161/01.CIR.102.9.1039
   Lommi J, 1998, AM J CARDIOL, V81, P45, DOI 10.1016/S0002-9149(97)00804-7
   Loverro G, 2002, GYNECOL OBSTET INVES, V53, P157, DOI 10.1159/000058367
   Lowe FC, 1999, UROLOGY, V53, P671, DOI 10.1016/S0090-4295(98)00664-5
   Marchesini G, 2002, HEPATOLOGY, V35, P497, DOI 10.1053/jhep.2002.31551
   Mattson MP, 1999, ANN NY ACAD SCI, V893, P154, DOI 10.1111/j.1749-6632.1999.tb07824.x
   McCarty MF, 2003, MED HYPOTHESES, V61, P167, DOI 10.1016/S0306-9877(02)00236-0
   Meininger G, 2002, METABOLISM, V51, P260, DOI 10.1053/meta.2002.29999
   Meydani SN, 1998, Z ERNAHRUNGSWISS, V37, P35
   MORTENSEN R, 1994, MACROPHAGE PATHOGEN, P143
   Nehra V, 2001, DIGEST DIS SCI, V46, P2347, DOI 10.1023/A:1012338828418
   NISHIDA Y, 1975, CLIN CHIM ACTA, V62, P103, DOI 10.1016/0009-8981(75)90285-5
   Oomen CM, 2001, LANCET, V357, P746, DOI 10.1016/S0140-6736(00)04166-0
   Outwater JL, 1997, MED HYPOTHESES, V48, P453, DOI 10.1016/S0306-9877(97)90110-9
   PECOITSFILHO R, 2001, JAMA-J AM MED ASSOC, V286, P327
   Pickup JC, 1998, DIABETOLOGIA, V41, P1241, DOI 10.1007/s001250051058
   Pollak M, 2000, EUR J CANCER, V36, P1224, DOI 10.1016/S0959-8049(00)00102-7
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   PRADHAN AD, 2001, DIABETES CARE, V24, P1936
   Prasad MR, 1998, NEUROCHEM RES, V23, P81, DOI 10.1023/A:1022457605436
   Preston T, 1998, J NUTR, V128, P1355, DOI 10.1093/jn/128.8.1355
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   REAVEN GM, 1988, DIABETES, V37, P1020, DOI 10.2337/diabetes.37.8.1020
   Reynish W, 2001, J GERONTOL A-BIOL, V56, pM675, DOI 10.1093/gerona/56.11.M675
   ROWE JW, 1987, SCIENCE, V237, P143, DOI 10.1126/science.3299702
   Rutkowski B, 1999, MINER ELECTROL METAB, V25, P65, DOI 10.1159/000057422
   Salmerón J, 2001, AM J CLIN NUTR, V73, P1019
   Schippling S, 2000, FREE RADICAL BIO MED, V28, P351, DOI 10.1016/S0891-5849(99)00247-6
   SCHOOK LB, 1976, INFECT IMMUN, V14, P564, DOI 10.1128/IAI.14.2.564-570.1976
   SCRAGG RKR, 1984, BMJ-BRIT MED J, V289, P521, DOI 10.1136/bmj.289.6444.521
   Sobel BE, 1999, P ASSOC AM PHYSICIAN, V111, P313, DOI 10.1046/j.1525-1381.1999.99231.x
   STEEL DM, 1994, IMMUNOL TODAY, V15, P81, DOI 10.1016/0167-5699(94)90138-4
   Stenvinkel P, 2002, KIDNEY INT, V62, P1791, DOI 10.1046/j.1523-1755.2002.00637.x
   Stoll BA, 2002, INT J OBESITY, V26, P747, DOI 10.1038/sj.ijo.0801998
   Stulnig TM, 2000, FASEB J, V14, P939, DOI 10.1096/fasebj.14.7.939
   SVENSON KLG, 1988, METABOLISM, V37, P125, DOI 10.1016/S0026-0495(98)90005-1
   Thomas EL, 1998, J APPL PHYSIOL, V85, P1778, DOI 10.1152/jappl.1998.85.5.1778
   Tucker KL, 2002, AM J CLIN NUTR, V76, P245, DOI 10.1093/ajcn/76.1.245
   VANNONI D, 1986, BIOMED PHARMACOTHER, V40, P348
   Vogel RA, 1997, AM J CARDIOL, V79, P350, DOI 10.1016/S0002-9149(96)00760-6
   Watson GS, 2003, CNS DRUGS, V17, P27, DOI 10.2165/00023210-200317010-00003
   WILLETT WC, 1993, LANCET, V341, P581, DOI 10.1016/0140-6736(93)90350-P
   Wilson DM, 1997, AM J PATHOL, V150, P2181
   Young-Hyman D, 2001, DIABETES CARE, V24, P1359, DOI 10.2337/diacare.24.8.1359
   Yu H, 2000, JNCI-J NATL CANCER I, V92, P1472, DOI 10.1093/jnci/92.18.1472
NR 103
TC 47
Z9 50
U1 0
U2 10
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD DEC
PY 2004
VL 23
IS 6
BP 1256
EP 1266
DI 10.1016/j.clnu.2004.07.016
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 879NJ
UT WOS:000225724200002
PM 15556248
DA 2025-06-11
ER

PT J
AU Pan, Y
   Kong, LD
AF Pan, Ying
   Kong, Ling-Dong
TI High fructose diet-induced metabolic syndrome: Pathophysiological
   mechanism and treatment by traditional Chinese medicine
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Traditional Chinese medicine (TCM); Fructose; Metabolic syndrome (MetS)
ID FATTY LIVER-DISEASE; NLRP3 INFLAMMASOME ACTIVATION; INDUCED
   INSULIN-RESISTANCE; INDUCED HEPATIC STEATOSIS; NECROSIS-FACTOR-ALPHA;
   NF-KAPPA-B; TANG-KE-LI; URIC-ACID; OXIDATIVE STRESS; LIPID-ACCUMULATION
AB Fructose is a natural monosaccharide broadly used in modern society. Over the past few decades, epidemiological studies have demonstrated that high fructose intake is an etiological factor of metabolic syndrome (MetS). This review highlights research advances on fructose-induced MetS, especially the underlying pathophysiological mechanism as well as pharmacotherapy by traditional Chinese medicine (TCM), using the PubMed, Web of science, China National Knowledge Infrastructure, China Science and Technology Journal and Wanfang Data. This review focuses on de novo lipogenesis (DNL) and uric acid (UA) production, two unique features of fructolysis different from glucose glycolysis. High level of DNL and UA production can result in insulin resistance, the key pathological event in developing MetS, mostly through oxidative stress and inflammation. Some other pathologies like the disturbance in brain and gut microbiota in the development of fructose-induced MetS in the past years, are also discussed. In management of MetS, TCM is an excellent representative in alternative and complementary medicine with a complete theory system and substantial herbal remedies. TCMs against MetS or MetS components, including Chinese patent medicines, TCM compound formulas, single TCM herbs and active compounds of TCM herbs, are reviewed on their effects and molecular mechanisms. TCMs with hypouricemic activity, which specially target fructose-induced MetS, are highlighted. And new technologies and strategies (such as high-throughput assay and systems biology) in this field are further discussed. In summary, fructose-induced MetS is a multifactorial disorder with the underlying complex mechanisms. Current clinical and pre-clinical evidence supports the potential of TCMs in management of MetS. Additionally, TCMs may show some advantages against complex MetS as their holistic feature through multiple target actions. However, further work is needed to confirm the effectivity and safety of TCMs by high-standard clinical trials, clarify the molecular mechanisms, and develop new anti-MetS drugs by development and application of optimized and feasible strategies and methods (C) 2018 Elsevier Ltd. All rights reserved.
C1 [Pan, Ying; Kong, Ling-Dong] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China.
C3 Nanjing University
RP Kong, LD (corresponding author), Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China.
EM kongld@nju.edu.cn
FU National Natural Science Foundation of China [81730105]
FX This work was supported by Grant from National Natural Science
   Foundation of China (No. 81730105) to Ling-Dong Kong.
CR Abdel-Megeid A. A. E. A., 2009, AGRICULTURA, V7, P24
   Aeberli I, 2011, AM J CLIN NUTR, V94, P479, DOI 10.3945/ajcn.111.013540
   Alwahsh SM, 2017, ARCH TOXICOL, V91, P1545, DOI 10.1007/s00204-016-1892-7
   [Anonymous], 2016, SIC REP
   Aroor AR, 2015, DIABETES, V64, P1988, DOI 10.2337/db14-0804
   Baena M, 2016, SCI REP-UK, V6, DOI 10.1038/srep26149
   Balakumar M, 2016, MOL CELL BIOCHEM, V423, P93, DOI 10.1007/s11010-016-2828-5
   Bao LD, 2016, EXP THER MED, V11, P1417, DOI 10.3892/etm.2016.3038
   Benetti E, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/509502
   Bergman RN, 2000, TRENDS ENDOCRIN MET, V11, P351, DOI 10.1016/S1043-2760(00)00323-4
   Bettaieb A, 2015, GASTROENTEROLOGY, V149, P468, DOI 10.1053/j.gastro.2015.04.009
   Bettaieb A, 2014, FREE RADICAL BIO MED, V72, P247, DOI 10.1016/j.freeradbiomed.2014.04.011
   Bierhaus A, 2005, J MOL MED, V83, P876, DOI 10.1007/s00109-005-0688-7
   Bouchard C, 2012, PROG MOL BIOL TRANSL, V108, P1, DOI 10.1016/B978-0-12-398397-8.00001-0
   Boulangé CL, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0303-2
   Bray GA, 2004, AM J CLIN NUTR, V79, P537
   Brozinick JT, 2013, INT J OBESITY, V37, P1064, DOI 10.1038/ijo.2012.191
   Brun P, 2007, AM J PHYSIOL-GASTR L, V292, pG518, DOI 10.1152/ajpgi.00024.2006
   Bursac BN, 2014, J NUTR BIOCHEM, V25, P446, DOI 10.1016/j.jnutbio.2013.12.005
   Cha SH, 2008, P NATL ACAD SCI USA, V105, P16871, DOI 10.1073/pnas.0809255105
   Chao Yung-Mei, 2016, Shengli Xuebao, V68, P557, DOI 10.13294/j.aps.2016.0064
   Chen KC, 2012, J BIOMOL STRUCT DYN, V30, P662, DOI 10.1080/07391102.2012.689699
   Chen LY, 2013, FOOD CHEM TOXICOL, V52, P28, DOI 10.1016/j.fct.2012.10.037
   Choi CS, 2008, P NATL ACAD SCI USA, V105, P19926, DOI 10.1073/pnas.0810339105
   Choi YJ, 2014, FASEB J, V28, P3197, DOI 10.1096/fj.13-247148
   Cirillo P, 2015, J THROMB THROMBOLYS, V40, P444, DOI 10.1007/s11239-015-1243-1
   Cox CL, 2012, EUR J CLIN NUTR, V66, P201, DOI 10.1038/ejcn.2011.159
   Crescenzo R, 2014, EXP PHYSIOL, V99, P1203, DOI 10.1113/expphysiol.2014.079632
   Crescenzo R, 2013, BRIT J NUTR, V110, P1996, DOI 10.1017/S0007114513001566
   Crescenzo R, 2013, EUR J NUTR, V52, P537, DOI 10.1007/s00394-012-0356-y
   Rodrigues MED, 2017, BRAIN BEHAV IMMUN, V59, P158, DOI 10.1016/j.bbi.2016.08.021
   Dekker MJ, 2013, ATHEROSCLEROSIS, V228, P98, DOI 10.1016/j.atherosclerosis.2013.01.041
   Di Luccia B, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0134893
   Ding XQ, 2015, MOL NUTR FOOD RES, V59, P2355, DOI 10.1002/mnfr.201500370
   Dirlewanger M, 2000, AM J PHYSIOL-ENDOC M, V279, pE907, DOI 10.1152/ajpendo.2000.279.4.E907
   Dogan S, 2012, GASTROENTEROLOGY, V143, pE29, DOI 10.1053/j.gastro.2012.07.012
   Duarte N, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/984578
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Fan CY, 2014, J NUTR BIOCHEM, V25, P353, DOI 10.1016/j.jnutbio.2013.11.010
   Feldstein AE, 2004, HEPATOLOGY, V40, P185, DOI 10.1002/hep.20283
   Fu J. Z., 2017, WORLD J TRADIT CHIN, V3, P1, DOI DOI 10.1080/14680629.2017.1373142
   Gaspers LD, 2010, BIOPHYS J, V98, p376A
   Ge CX, 2016, EUR J PHARMACOL, V770, P154, DOI 10.1016/j.ejphar.2015.11.043
   Gugliucci A, 2017, ADV NUTR, V8, P54, DOI 10.3945/an.116.013912
   Hamilton JA, 2007, PROSTAG LEUKOTR ESS, V77, P355, DOI 10.1016/j.plefa.2007.10.020
   Han X, 2016, CHEM-BIOL INTERACT, V257, P132, DOI 10.1016/j.cbi.2016.08.002
   Hirabara SM, 2012, J BIOMED BIOTECHNOL, DOI 10.1155/2012/379024
   Honma K, 2013, BIOSCI BIOTECH BIOCH, V77, P2188, DOI 10.1271/bbb.130300
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Hsieh CC, 2016, J FOOD DRUG ANAL, V24, P754, DOI 10.1016/j.jfda.2016.03.005
   Hsu JH, 2007, J ETHNOPHARMACOL, V112, P577, DOI 10.1016/j.jep.2007.05.013
   Hu QH, 2012, BIOCHEM PHARMACOL, V84, P113, DOI 10.1016/j.bcp.2012.03.005
   Hu QH, 2009, AM J PHYSIOL-RENAL, V297, pF1080, DOI 10.1152/ajprenal.90767.2008
   Hu QL, 2017, PHARMACOL RES, V119, P371, DOI 10.1016/j.phrs.2017.02.025
   Hu XC, 2014, INT CONF DIGIT SIG, P1, DOI 10.1109/ICDSP.2014.6900715
   Huang JP, 2017, J DIABETES, V9, P936, DOI 10.1111/1753-0407.12505
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Ibrahim SM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0117516
   Inoguchi T, 2000, DIABETES, V49, P1939, DOI 10.2337/diabetes.49.11.1939
   Jaiswal N, 2015, APOPTOSIS, V20, P930, DOI 10.1007/s10495-015-1128-y
   Jiang LR, 2016, J ETHNOPHARMACOL, V194, P288, DOI 10.1016/j.jep.2016.09.009
   Jiménez-Maldonado A, 2018, BBA-MOL BASIS DIS, V1864, P24, DOI 10.1016/j.bbadis.2017.10.012
   Jin CJ, 2017, J GASTROEN HEPATOL, V32, P708, DOI 10.1111/jgh.13488
   Jin X, 2010, J ETHNOPHARMACOL, V128, P672, DOI 10.1016/j.jep.2010.02.019
   Johnson RJ, 2013, J EQUINE VET SCI, V33, P120, DOI 10.1016/j.jevs.2012.05.004
   Jones HF, 2011, AM J PHYSIOL-GASTR L, V300, pG202, DOI 10.1152/ajpgi.00457.2010
   Jürgens H, 2005, OBES RES, V13, P1146, DOI 10.1038/oby.2005.136
   Kannappan S, 2010, EUR J PHARMACOL, V645, P177, DOI 10.1016/j.ejphar.2010.07.015
   Kanuri G, 2011, J NUTR BIOCHEM, V22, P527, DOI 10.1016/j.jnutbio.2010.04.007
   Kelany ME, 2017, CAN J PHYSIOL PHARM, V95, P140, DOI 10.1139/cjpp-2016-0152
   Kim SM, 2015, AM J PHYSIOL-RENAL, V308, pF993, DOI 10.1152/ajprenal.00637.2014
   Kinote A, 2012, ENDOCRINOLOGY, V153, P3633, DOI 10.1210/en.2012-1341
   Kovacevic S, 2017, EUR J NUTR, V56, P151, DOI 10.1007/s00394-015-1065-0
   Kyriazis GA, 2012, P NATL ACAD SCI USA, V109, pE524, DOI 10.1073/pnas.1115183109
   Lanaspa MA, 2012, J BIOL CHEM, V287, P40732, DOI 10.1074/jbc.M112.399899
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Li JM, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/303902
   Li JM, 2010, HEPATOLOGY, V51, P1555, DOI 10.1002/hep.23524
   Li RW, 2006, J ETHNOPHARMACOL, V104, P24, DOI 10.1016/j.jep.2005.08.045
   Li SZ, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0159230
   Li WF, 2016, FOOD FUNCT, V7, P2420, DOI 10.1039/c6fo00038j
   Li Y, 2000, HYPERTENS RES, V23, P101, DOI 10.1291/hypres.23.101
   Lim JS, 2010, NAT REV GASTRO HEPAT, V7, P251, DOI 10.1038/nrgastro.2010.41
   LIU C, 2013, EVID-BASED COMPL ALT, V2013
   Liu IM, 2011, EVID-BASED COMPL ALT, V2011
   Liu J, 2014, FOOD FUNCT, V5, P1038, DOI 10.1039/c3fo60524h
   Liu J, 2014, CLIN EXP PHARMACOL P, V41, P482, DOI 10.1111/1440-1681.12241
   Liu QF, 2014, J ETHNOPHARMACOL, V151, P287, DOI 10.1016/j.jep.2013.10.031
   Liu Q, 2010, J STEROID BIOCHEM, V120, P155, DOI 10.1016/j.jsbmb.2010.03.090
   Liu XX, 2015, ASIAN PAC J TROP MED, V8, P162, DOI 10.1016/S1995-7645(14)60309-6
   Livesey G, 2008, AM J CLIN NUTR, V88, P1419, DOI 10.3945/ajcn.2007.25700
   Lowette Katrien, 2015, Front Nutr, V2, P5, DOI 10.3389/fnut.2015.00005
   Ma CH, 2015, J ETHNOPHARMACOL, V172, P108, DOI 10.1016/j.jep.2015.06.015
   Madlala HP, 2016, NUTR REV, V74, P259, DOI 10.1093/nutrit/nuv111
   Maessen DEM, 2015, CLIN SCI, V128, P839, DOI 10.1042/CS20140683
   Maithilikarpagaselvi N, 2016, PHARM BIOL, V54, P2857, DOI 10.1080/13880209.2016.1187179
   Maithilikarpagaselvi N, 2016, CHEM-BIOL INTERACT, V244, P187, DOI 10.1016/j.cbi.2015.12.012
   MAYES PA, 1993, AM J CLIN NUTR, V58, P754
   Miller A, 2008, CURR OPIN GASTROEN, V24, P204, DOI 10.1097/MOG.0b013e3282f3f4c4
   Miyamoto T, 2012, CELL, V151, P1113, DOI 10.1016/j.cell.2012.10.024
   Moreno JA, 2013, NUTR METAB CARDIOVAS, V23, P536, DOI 10.1016/j.numecd.2011.10.008
   Morimoto Yasuo, 2001, Folia Pharmacologica Japonica, V117, P77, DOI 10.1254/fpj.117.77
   Nakagawa T, 2006, AM J PHYSIOL-RENAL, V290, pF625, DOI 10.1152/ajprenal.00140.2005
   Ohashi K, 2015, BIOCHEM BIOPH RES CO, V468, P185, DOI 10.1016/j.bbrc.2015.10.134
   Oppelt SA, 2017, BRAIN RES, V1657, P312, DOI 10.1016/j.brainres.2016.12.022
   Page KA, 2013, JAMA-J AM MED ASSOC, V309, P63, DOI 10.1001/jama.2012.116975
   Palanisamy N, 2011, EUR J PHARMACOL, V667, P355, DOI 10.1016/j.ejphar.2011.06.011
   Pan Y., 2016, WORLD SCI TECHNOL MO, V09, P1441
   Parekh PJ, 2015, CLIN TRANSL GASTROEN, V6, DOI 10.1038/ctg.2015.16
   Payne AN, 2012, OBES REV, V13, P799, DOI 10.1111/j.1467-789X.2012.01009.x
   Pektas MB, 2016, BIOMED RES INT, V2016, DOI 10.1155/2016/8014252
   Pham TX, 2012, NUTRIENTS, V4, P1868, DOI 10.3390/nu4121868
   Porto ML, 2015, TOXICOL IN VITRO, V29, P1977, DOI 10.1016/j.tiv.2015.08.006
   Posey KA, 2009, AM J PHYSIOL-ENDOC M, V296, pE1003, DOI 10.1152/ajpendo.90377.2008
   Prakash P, 2014, EUR J PHARMACOL, V727, P15, DOI 10.1016/j.ejphar.2014.01.038
   Qiao YJ, 2018, TOXICOL LETT, V284, P37, DOI 10.1016/j.toxlet.2017.11.031
   Qiu J, 2007, NATURE, V448, P126, DOI 10.1038/448126a
   Rajasekar P, 2008, DIABETES OBES METAB, V10, P171, DOI 10.1111/j.1463-1326.2007.00825.x
   Ramkissoon JS, 2016, ASIAN PAC J TROP BIO, V6, P492, DOI 10.1016/j.apjtb.2016.01.016
   Rivero-Gutiérrez B, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600622
   Rizkalla SW, 2010, NUTR METAB, V7, DOI 10.1186/1743-7075-7-82
   Roncal-Jimenez CA, 2011, METABOLISM, V60, P1259, DOI 10.1016/j.metabol.2011.01.008
   Roskoski R, 2017, PHARMACOL RES, V119, P240, DOI 10.1016/j.phrs.2017.02.005
   Sánchez I, 2015, GENES NUTR, V10, DOI 10.1007/s12263-015-0471-5
   Sánchez-Lozada LG, 2012, NEPHRON EXP NEPHROL, V121, pE71, DOI 10.1159/000345509
   Santos F., 2017, FASEB J S, V1, P853
   Sautin YY, 2007, AM J PHYSIOL-CELL PH, V293, pC584, DOI 10.1152/ajpcell.00600.2006
   Schwarz JM, 2017, J AM OSTEOPATH ASSOC, V117, P520, DOI 10.7556/jaoa.2017.102
   SCHWARZ JM, 1989, AM J CLIN NUTR, V49, P667, DOI 10.1093/ajcn/49.4.667
   Sellmann C, 2015, J NUTR BIOCHEM, V26, P1183, DOI 10.1016/j.jnutbio.2015.05.011
   Shi LJ, 2013, EUR J PHARMACOL, V714, P89, DOI 10.1016/j.ejphar.2013.06.013
   Sievenpiper JL, 2014, CURR OPIN LIPIDOL, V25, P8, DOI 10.1097/MOL.0000000000000042
   Sievenpiper JL, 2012, ANN INTERN MED, V156, P291, DOI 10.7326/0003-4819-156-4-201202210-00007
   Spruss A, 2009, HEPATOLOGY, V50, P1094, DOI 10.1002/hep.23122
   Stanhope KL, 2009, J CLIN INVEST, V119, P1322, DOI 10.1172/JCI37385
   Stanhope KL, 2008, AM J CLIN NUTR, V88, p1733S, DOI 10.3945/ajcn.2008.25825D
   Sud N, 2017, J NUTR BIOCHEM, V43, P125, DOI 10.1016/j.jnutbio.2017.02.003
   Tan Y, 2011, CLIN SCI, V120, P297, DOI 10.1042/CS20100441
   TAPPY L, 1986, AM J PHYSIOL, V250, pE718, DOI 10.1152/ajpendo.1986.250.6.E718
   Thuy S, 2008, J NUTR, V138, P1452, DOI 10.1093/jn/138.8.1452
   Tschopp J, 2011, EUR J IMMUNOL, V41, P1196, DOI 10.1002/eji.201141436
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Umekawa T, 2003, NEPHROL DIAL TRANSPL, V18, P664, DOI 10.1093/ndt/gfg140
   van Buul VJ, 2014, NUTR RES REV, V27, P119, DOI 10.1017/S0954422414000067
   Vilà L, 2008, HEPATOLOGY, V48, P1506, DOI 10.1002/hep.22523
   Vos MB, 2009, HEPATOLOGY, V50, P1004, DOI 10.1002/hep.23212
   Wan XY, 2016, J HEPATOL, V64, P925, DOI 10.1016/j.jhep.2015.11.022
   Wang L, 2003, HYPERTENS RES, V26, P527, DOI 10.1291/hypres.26.527
   Wang L, 2001, HYPERTENS RES, V24, P303, DOI 10.1291/hypres.24.303
   Wang M, 2005, PHYTOTHER RES, V19, P173, DOI 10.1002/ptr.1624
   Wang MX, 2016, J AGR FOOD CHEM, V64, P7899, DOI 10.1021/acs.jafc.6b03031
   Wang W, 2015, FREE RADICAL BIO MED, V83, P214, DOI 10.1016/j.freeradbiomed.2015.02.029
   Wang X, 2013, BIOCHEM PHARMACOL, V86, P1791, DOI 10.1016/j.bcp.2013.10.005
   Wang Y., 2015, EVID-BASED COMPL ALT, V2015
   Wang YQ, 2015, MED SCI MONITOR, V21, P2163, DOI 10.12659/MSM.893972
   Wen HT, 2011, NAT IMMUNOL, V12, P408, DOI 10.1038/ni.2022
   Xing XM, 2014, TOXICOL APPL PHARM, V280, P207, DOI 10.1016/j.taap.2014.08.001
   Xu F, 2017, EUR J INTEGR MED, V14, P32, DOI 10.1016/j.eujim.2017.08.008
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Xu MX, 2016, BRAIN BEHAV IMMUN, V58, P69, DOI 10.1016/j.bbi.2016.01.001
   Yamazaki M, 2016, LIFE SCI, V149, P146, DOI 10.1016/j.lfs.2016.02.020
   Yang Y, 2015, J ETHNOPHARMACOL, V169, P49, DOI 10.1016/j.jep.2015.04.011
   Yin Jun, 2008, Endocrine Metabolic & Immune Disorders-Drug Targets, V8, P99, DOI 10.2174/187153008784534330
   Yuan L, 2016, J AGR FOOD CHEM, V64, P2682, DOI 10.1021/acs.jafc.6b00290
   Zeng XY, 2012, BIOCHEM PHARMACOL, V84, P830, DOI 10.1016/j.bcp.2012.07.003
   Zhang DM, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040335
   Zhang DM, 2012, FOOD CHEM, V134, P2184, DOI 10.1016/j.foodchem.2012.04.026
   Zhang QY, 2014, J NUTR BIOCHEM, V25, P420, DOI 10.1016/j.jnutbio.2013.11.014
   Zhang X, 2015, ANTIOXID REDOX SIGN, V22, P848, DOI 10.1089/ars.2014.5868
   Zhang XQ, 2008, CELL, V135, P61, DOI 10.1016/j.cell.2008.07.043
   Zhao YY, 2015, J TRANSL MED, V13, DOI 10.1186/s12967-015-0529-6
   Zhu YZ, 2014, BIOCHEM BIOPH RES CO, V447, P707, DOI 10.1016/j.bbrc.2014.04.080
NR 172
TC 55
Z9 58
U1 3
U2 77
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
J9 PHARMACOL RES
JI Pharmacol. Res.
PD APR
PY 2018
VL 130
BP 438
EP 450
DI 10.1016/j.phrs.2018.02.020
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GG9JN
UT WOS:000433016900038
PM 29471102
DA 2025-06-11
ER

PT J
AU Rosenbaum, S
   Stubbs, B
   Ward, PB
   Steel, Z
   Lederman, O
   Vancampfort, D
AF Rosenbaum, Simon
   Stubbs, Brendon
   Ward, Philip B.
   Steel, Zachary
   Lederman, Oscar
   Vancampfort, Davy
TI The prevalence and risk of metabolic syndrome and its components among
   people with posttraumatic stress disorder: a systematic review and
   meta-analysis
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Review
DE PTSD; Metabolic syndrome; Glucose; Cardiovascular disease; Lipids
ID 3RD NATIONAL-HEALTH; US ADULTS; ABNORMALITIES; SCHIZOPHRENIA; MORTALITY;
   DISEASE; HEART; PTSD; ASSOCIATION; POPULATION
AB Objective. People with posttraumatic stress disorder (PTSD) have a higher mortality than the general population, mainly due to cardiovascular diseases (CVD). Metabolic syndrome (MetS) and its components are highly predictive of CVD. The aim of this meta-analysis was to describe pooled frequencies of MetS and its components in people with PTSD and to compare MetS prevalence in PTSD versus the general population.
   Method. Medline, PsycARTICLES, Embase and CINAHL were searched until 02/2015 for cross-sectional and baseline data of longitudinal studies in adults with PTSD. Two independent reviewers conducted the searches and extracted data. Random effects meta-analysis with a relative risk, subgroups and meta-regression analyses were employed.
   Results. Overall, 9 studies met the inclusion criteria including 9,673 individuals in midlife with PTSD and 6852 general population controls. The pooled MetS prevalence was 38.7% (95% CI = 32.1%-45.6%; Q = 52.1, p < 0.001; N = 9; n = 9,673; age range = 44-61 years). Abdominal obesity was observed in 49.3% (95% CI = 29.7%-69.0%), hyperglycemia in 36.1% (95% CI = 18.8%-55.6%), hypertriglyceridemia in 45.9% (95% CI = 12.2%-81.9%), low high density-lipoprotein-cholesterol in 46.4% (95% CI = 26.4%-67.0%) and hypertension in 76.9% (95% CI = 67.9%-84.8%). The MetS prevalence was consistently high across geographical regions, settings or populations (war veterans or not). Compared with matched general population controls, people with PTSD had an almost double increased risk for MetS (RR = 1.82; 95% CI = 1.72-1.92; p <0.001). Most analyses were not statistically heterogeneous.
   Conclusions. MetS is highly prevalent in people with PTSD. Routine screening and multidisciplinary management of medical and behavioral conditions is needed. Future research should focus on how cardio-metabolic outcomes are moderated by clinical and treatment characteristics and genetic factors. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Rosenbaum, Simon; Ward, Philip B.; Steel, Zachary; Lederman, Oscar] Univ New S Wales, Sch Psychiat, Sydney, NSW, Australia.
   [Stubbs, Brendon] Univ Greenwich, Sch Hlth & Social Care, London SE18 6PF, England.
   [Vancampfort, Davy] KU Leuven Univ Leuven, UPC KU Leuven, Dept Neurosci, B-3070 Kortenberg, Belgium.
   [Vancampfort, Davy] KU Leuven Univ Leuven, Dept Rehabil Sci, Leuven, Belgium.
C3 University of New South Wales Sydney; University of Greenwich; KU
   Leuven; KU Leuven
RP Vancampfort, D (corresponding author), KU Leuven Univ Leuven, UPC KU Leuven, Dept Neurosci, Campus Kortenberg,Leuvensesteenweg 517, B-3070 Kortenberg, Belgium.
EM davy.vancampfort@uc-kortenberg.be
RI Vancampfort, Davy/AAD-1987-2019; Stubbs, Brendon/X-1904-2018; Rosenbaum,
   Simon/Y-3241-2019; Steel, Zachary/MEQ-2709-2025; Ward,
   Philip/JCE-6293-2023; Stubbs, Brendon/C-5696-2015
OI Ward, Philip/0000-0002-5779-7722; Rosenbaum, Simon/0000-0002-8984-4941;
   Stubbs, Brendon/0000-0001-7387-3791; Berle, David/0000-0002-4861-2220;
   Lederman, Oscar/0000-0002-0321-5723; Steel, Zachary/0000-0002-5048-2920
FU Research Foundation-Flanders (FWO-Vlaanderen)
FX Dr. Vancampfort has received grant support from the Research
   Foundation-Flanders (FWO-Vlaanderen). The other authors have no
   disclosures to report. The current work was not funded.
CR Ahmadi N, 2011, AM J CARDIOL, V108, P29, DOI 10.1016/j.amjcard.2011.02.340
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   [Anonymous], ICD 10 CLASS MENT BE
   [Anonymous], 2019, DIAGN STAT MAN MENT
   [Anonymous], EFFECT ANTIDEPRESSAN
   [Anonymous], J NEUROPSYCH CLIN N
   Babic R, 2013, PSYCHIAT DANUB, V25, P45
   Bartoli F, 2013, METAB SYNDR RELAT D, V11, P301, DOI 10.1089/met.2013.0010
   BEGG CB, 1994, BIOMETRICS, V50, P1088, DOI 10.2307/2533446
   Blanco C, 2013, DRUG ALCOHOL DEPEN, V132, P630, DOI 10.1016/j.drugalcdep.2013.04.016
   Boscarino JA, 2006, ANN EPIDEMIOL, V16, P248, DOI 10.1016/j.annepidem.2005.03.009
   Boscarino JA, 2004, ANN NY ACAD SCI, V1032, P141, DOI 10.1196/annals.1314.011
   Boscarino JA, 2008, J NERV MENT DIS, V196, P100, DOI 10.1097/NMD.0b013e318162a9f5
   Carmassi C, 2015, PSYCHIAT RES, V225, P64, DOI 10.1016/j.psychres.2014.10.008
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Davidson Jonathan R T, 2010, J Clin Psychiatry, V71 Suppl E1, pe04, DOI 10.4088/JCP.9058se1c.04gry
   Dedert EA, 2010, ANN BEHAV MED, V39, P61, DOI 10.1007/s12160-010-9165-9
   DERSIMONIAN R, 1986, CONTROL CLIN TRIALS, V7, P177, DOI 10.1016/0197-2456(86)90046-2
   Egger M, 1997, BMJ-BRIT MED J, V315, P629, DOI 10.1136/bmj.315.7109.629
   Eraly SA, 2014, JAMA PSYCHIAT, V71, P423, DOI 10.1001/jamapsychiatry.2013.4374
   Farr OM, 2014, METABOLISM, V63, P1463, DOI 10.1016/j.metabol.2014.08.009
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Fu SS, 2007, NICOTINE TOB RES, V9, P1071, DOI 10.1080/14622200701488418
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Gavin JR, 1997, DIABETES CARE, V20, P1183
   Godfrey KM, 2013, ANN GEN PSYCHIATR, V12, DOI 10.1186/1744-859X-12-30
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hennings JM, 2012, CURR PHARM DESIGN, V18, P5900
   Heppner PS, 2009, BMC MED, V7, DOI 10.1186/1741-7015-7-1
   Jakovljevic M, 2008, PSYCHIAT DANUB, V20, P406
   Jin H, 2009, J CLIN PSYCHOPHARM, V29, P210, DOI 10.1097/JCP.0b013e3181a45ed0
   Knol MJ, 2008, PHARMACOEPIDEM DR S, V17, P577, DOI 10.1002/pds.1608
   Leslie DL, 2009, PSYCHIAT SERV, V60, P1174, DOI 10.1176/ps.2009.60.9.1175
   Li H, 2014, FRONT NEUROL, V5, DOI 10.3389/fneur.2014.00164
   Linnville S, 2011, MIL MED, V176, P369, DOI 10.7205/MILMED-D-10-00367
   Maslov B, 2008, PSYCHIAT DANUB, V20, P384
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P295, DOI 10.1093/schbul/sbs082
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Mojtabai R, 2013, PSYCHOPHARMACOLOGY, V227, P467, DOI 10.1007/s00213-013-2972-5
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Nevell L, 2014, PSYCHONEUROENDOCRINO, V43, P62, DOI 10.1016/j.psyneuen.2014.01.013
   Pacella ML, 2013, J ANXIETY DISORD, V27, P33, DOI 10.1016/j.janxdis.2012.08.004
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Rosenbaum S, 2015, ACTA PSYCHIAT SCAND, V131, P350, DOI 10.1111/acps.12371
   Stroup DF, 2000, JAMA-J AM MED ASSOC, V283, P2008, DOI 10.1001/jama.283.15.2008
   Vaccarino V, 2013, J AM COLL CARDIOL, V62, P970, DOI 10.1016/j.jacc.2013.04.085
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vancampfort D, 2013, WORLD PSYCHIATRY, V12, P240, DOI 10.1002/wps.20069
   Vancampfort D, 2013, AM J PSYCHIAT, V170, P265, DOI 10.1176/appi.ajp.2012.12050620
   Violanti John M, 2006, Int J Emerg Ment Health, V8, P227
   Weiss T, 2011, GEN HOSP PSYCHIAT, V33, P135, DOI 10.1016/j.genhosppsych.2011.01.002
   Xue Y, 2012, AM J CARDIOL, V109, P1215, DOI 10.1016/j.amjcard.2011.11.063
   Zen AL, 2012, HEALTH PSYCHOL, V31, P194, DOI 10.1037/a0025989
NR 56
TC 172
Z9 183
U1 0
U2 22
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD AUG
PY 2015
VL 64
IS 8
BP 926
EP 933
DI 10.1016/j.metabol.2015.04.009
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CK7HB
UT WOS:000356402300009
PM 25982700
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Dai, WY
   Wagh, SA
   Chettiar, S
   Zhou, GD
   Roy, R
   Qiao, XY
   Visich, PS
   Hoffman, EP
AF Dai, Weiying
   Wagh, Swanand A.
   Chettiar, Steffi
   Zhou, Grace D.
   Roy, Runia
   Qiao, Xingye
   Visich, Paul S.
   Hoffman, Eric P.
TI Blunted circadian cortisol in children is associated with poor
   cardiovascular health and may reflect circadian misalignment
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Circadian rhythm; Blood pressure; Metabolic syndrome; Cortisol
ID EARLY SOCIAL DEPRIVATION; DISEASE RISK-FACTORS; BLOOD-PRESSURE;
   METABOLIC SYNDROME; SERUM CORTISOL; LTC RELATION; OBESITY; STRESS;
   INFLAMMATION; ADOLESCENTS
AB Objectives: Circadian cues in children (sunlight, exercise, diet patterns) may be associated with health outcomes. The primary objective was to assess associations of daily cortisol fluctuations (morning, night) with cardiovascular health outcomes. A secondary objective was to determine if 1-year longitudinal changes in circadian cortisol levels are associated with longitudinal changes in health outcomes.
   Study design: The Cardiovascular Health Intervention Program (CHIP) was a cross-sectional and longitudinal study of cardiovascular risk profiles in public elementary school children in Southern Maine. Participants were 689 students in 4th grade (baseline; age = 9.20 +/- 0.41 years), and 647 students in 5th grade (age = 10.53 +/- 0.52 years). Longitudinal data (4th and 5th grade) was available for 347 participants. Clinical outcomes were blood pressure, hip/waist ratios, body mass index, percent fat. Laboratory measures were fasting glucose, lipids, and salivary cortisol measures (morning and evening).
   Results: Lower first-in-morning diurnal cortisol levels were associated with increased blood pressure beta -0.23 +/- 0.05; p < 0.001), increased body fat (beta -0.22 +/- 0.05; p < 0.001), and poor lipid profiles (beta -0.15 +/- 0.07; p < 0.05). Inclusion of night cortisol in the model (stress-related) improved associations of the model with bodyfat composition (morning beta -0.27 +/- 0.05; p < 0.001; night beta +0.16 +/- 0.06; p < 0.01). Adjustments for potential confounding variables improved associations of morning cortisol with lipids (beta -0.19 +/- 0.07; p < 0.01). Longitudinal analysis showed that lower morning diurnal cortisol in 4th grade was associated with increases in blood pressure a year later (beta -0.18 +/- 0.08; p = 0.017) after adjusting for confounding variables.
   Conclusion: Data presented suggest adding circadian misalignment (lower amplitude of first-in-morning cortisol) to existing models of metabolic syndrome in children. Further, circadian misalignment may be a factor contributing to high blood pressure.
C1 [Dai, Weiying; Wagh, Swanand A.; Chettiar, Steffi] SUNY Binghamton, Dept Comp Sci, Binghamton, NY 13902 USA.
   [Zhou, Grace D.; Roy, Runia; Hoffman, Eric P.] SUNY Binghamton, Dept Pharmaceut Sci, Binghamton, NY 13902 USA.
   [Roy, Runia] SUNY Binghamton, Dept Biomed Engn, Binghamton, NY 13902 USA.
   [Qiao, Xingye] SUNY Binghamton, Dept Math Sci, Binghamton, NY 13902 USA.
   [Visich, Paul S.] Univ New England, Exercise & Sport Performance Dept, Biddeford, ME USA.
C3 State University of New York (SUNY) System; Binghamton University, SUNY;
   State University of New York (SUNY) System; Binghamton University, SUNY;
   State University of New York (SUNY) System; Binghamton University, SUNY;
   State University of New York (SUNY) System; Binghamton University, SUNY;
   University of New England - Maine
RP Hoffman, EP (corresponding author), SUNY Binghamton, Dept Pharmaceut Sci, Binghamton, NY 13902 USA.
EM ehoffman@binghamton.edu
RI Zhou, Grace/KBA-5091-2024; Qiao, Xingye/P-6321-2019; Hoffman,
   Eric/KYP-6390-2024
OI Qiao, Xingye/0000-0003-0937-9822
CR Alibhai FJ, 2017, J MOL CELL CARDIOL, V105, P24, DOI 10.1016/j.yjmcc.2017.01.008
   Apter-Levi Y, 2016, PSYCHONEUROENDOCRINO, V64, P47, DOI 10.1016/j.psyneuen.2015.11.006
   Barnes PJ, 2006, BRIT J PHARMACOL, V148, P245, DOI 10.1038/sj.bjp.0706736
   Benchimol EI, 2014, INFLAMM BOWEL DIS, V20, P1761, DOI 10.1097/MIB.0000000000000103
   Berenson GS, 2002, AM J CARDIOL, V90, p3L, DOI 10.1016/S0002-9149(02)02953-3
   Bosma-den Boer MM, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-32
   Doane LD, 2015, PSYCHONEUROENDOCRINO, V55, P21, DOI 10.1016/j.psyneuen.2015.01.017
   Ehlers A, 2018, MUCOSAL IMMUNOL, V11, P97, DOI 10.1038/mi.2017.24
   Feder A, 2004, BIOL PSYCHIAT, V56, P198, DOI 10.1016/j.biopsych.2004.05.005
   Filipovsky J, 1996, J HYPERTENS, V14, P229, DOI 10.1097/00004872-199602000-00012
   Filipovsky J., 2018, INT J ENV RES PUB HE, V15, P15
   Fries ABW, 2008, DEV PSYCHOBIOL, V50, P588, DOI 10.1002/dev.20319
   Gombert M, 2019, TRANSL RES, V206, P107, DOI 10.1016/j.trsl.2018.12.001
   Haahtela T, 2019, CLIN TRANSL ALLERGY, V9, DOI 10.1186/s13601-019-0295-2
   Hellhammer J, 2007, PSYCHONEUROENDOCRINO, V32, P80, DOI 10.1016/j.psyneuen.2006.10.005
   Hostinar CE, 2015, DEV PSYCHOL, V51, P1597, DOI 10.1037/dev0000029
   Hu LT, 1999, STRUCT EQU MODELING, V6, P1, DOI 10.1080/10705519909540118
   Inokawa H, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-59541-y
   Jakubowicz D, 2019, DIABETES CARE, V42, P2171, DOI 10.2337/dc19-1142
   Kushner MR, 2016, J ABNORM CHILD PSYCH, V44, P859, DOI 10.1007/s10802-015-0087-7
   Lee CJ, 2020, ANN NY ACAD SCI, V1461, P37, DOI 10.1111/nyas.14107
   Liu XJ, 2017, INFLAMM BOWEL DIS, V23, P1741, DOI 10.1097/MIB.0000000000001265
   Lundbäck B, 2016, EXPERT REV RESP MED, V10, P39, DOI 10.1586/17476348.2016.1114417
   McAloon CJ, 2016, INT J CARDIOL, V224, P256, DOI 10.1016/j.ijcard.2016.09.026
   Morris CJ, 2016, P NATL ACAD SCI USA, V113, pE1402, DOI 10.1073/pnas.1516953113
   Ng SC, 2017, LANCET, V390, P2769, DOI 10.1016/S0140-6736(17)32448-0
   Papafotiou C, 2017, STRESS, V20, P217, DOI 10.1080/10253890.2017.1303830
   Prodam F, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-44
   Reynolds RM, 2003, METABOLISM, V52, P524, DOI 10.1053/meta.2003.50090
   Rice M, 2018, BIOL RES NURS, V20, P25, DOI 10.1177/1099800417726598
   Ricotti R, 2020, EUR J ENDOCRINOL, V182, P255, DOI 10.1530/EJE-19-0792
   Sallam N, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/7239639
   Saltiel AR, 2017, J CLIN INVEST, V127, P1, DOI [10.1172/JCI92035, 10.1172/jci92035]
   Serebrisky D, 2019, ANN GLOB HEALTH, V85, DOI 10.5334/aogh.2416
   Soriano-Rodríguez P, 2010, PEDIATR RES, V68, P452, DOI 10.1203/PDR.0b013e3181efc310
   Stroud CB, 2016, DEV PSYCHOBIOL, V58, P700, DOI 10.1002/dev.21410
   Tahara Y, 2017, J PHYSIOL SCI, V67, P1, DOI 10.1007/s12576-016-0450-7
   Ticinesi A, 2019, EXERC IMMUNOL REV, V25, P8
   Trott AJ, 2018, PLOS GENET, V14, DOI 10.1371/journal.pgen.1007156
   Veldhorst MAB, 2014, J CLIN ENDOCR METAB, V99, P285, DOI 10.1210/jc.2013-2924
   Walker BR, 2000, J INTERN MED, V247, P198, DOI 10.1046/j.1365-2796.2000.00609.x
   Ward AMV, 2003, CLIN ENDOCRINOL, V58, P500, DOI 10.1046/j.1365-2265.2003.01750.x
   Weigensberg MJ, 2008, J CLIN ENDOCR METAB, V93, P1372, DOI 10.1210/jc.2007-2309
   White D, 2017, J PEDIATR-US, V190, P38, DOI 10.1016/j.jpeds.2017.07.034
   Yeung EW, 2016, PSYCHONEUROENDOCRINO, V71, P110, DOI 10.1016/j.psyneuen.2016.05.013
   Zhang JH, 2016, SCI REP-UK, V6, DOI 10.1038/srep22531
   Zhou B, 2016, LANCET, V387, P1513, DOI 10.1016/S0140-6736(16)00618-8
NR 47
TC 8
Z9 8
U1 2
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JUL
PY 2021
VL 129
AR 105252
DI 10.1016/j.psyneuen.2021.105252
EA MAY 2021
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA SR9ZR
UT WOS:000661403000013
PM 34049197
OA hybrid
DA 2025-06-11
ER

PT J
AU Cheng, H
   Zhou, JY
   Sun, YT
   Zhan, QP
   Zhang, DF
AF Cheng, Hao
   Zhou, Jingyang
   Sun, Yutong
   Zhan, Qipeng
   Zhang, Dunfang
TI High fructose diet: A risk factor for immune system dysregulation
SO HUMAN IMMUNOLOGY
LA English
DT Review
DE Fructose; Inflammation; Autoimmunity; Cancer; Microbiota
ID TOLL-LIKE RECEPTOR; INTESTINAL BARRIER FUNCTION; CHAIN FATTY-ACIDS;
   OXIDATIVE STRESS; URIC-ACID; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   HEPATIC STEATOSIS; LIVER; INFLAMMATION
AB Excessive intake of sweets is a predisposing factor for metabolic disorders, and fructose, as one of the major dietary sugars in the diet, has been shown to be a major cause of obesity, diabetes, and metabolic syndrome. These disorders are usually associated with immune dysfunction. Therefore, exploring the effects of a high fructose diet on the immune system may provide insight into the underlying mechanisms of these diseases. We synthesized the available evidence to suggest that excessive fructose intake disrupts the body's immune homeostasis by promoting immune cell metabolic rearrangements, alterations in gut microbial community structure, and intestinal barrier permeability. Indeed, not only does fructose itself affect immune system homeostasis, but its metabolites also have a profound influence. The metabolites from fructolysis are mainly produced in the small intestine and liver and subsequently enter the systemic circulation. Elevated levels of fructose metabolites, such as uric acid, FFAs, and lactate, are closely associated with oxidative stress and local tissue and organ inflammatory responses. In this review, we will focus on the link between fructose and inflammatory responses. In the meanwhile, we will also briefly summarize the studies of cancer development and immune escape mediated by fructose, as it might be beneficial for cancer immunotherapy. (c) 2022 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
C1 [Zhang, Dunfang] Sichuan Univ, State Key Lab Biotherapy, Dept Biotherapy, Chengdu, Sichuan, Peoples R China.
   Sichuan Univ, West China Hosp, Canc Ctr, Chengdu, Sichuan, Peoples R China.
C3 Sichuan University; Sichuan University
RP Zhang, DF (corresponding author), Sichuan Univ, State Key Lab Biotherapy, Dept Biotherapy, Chengdu, Sichuan, Peoples R China.
EM izdf@163.com
RI Zhou, Jingyang/AAO-1184-2021
OI Zhang, Dunfang/0000-0001-7545-9930; Zhan, Qipeng/0009-0008-8510-6758
FU National Natural Science Foundation of China [82171829]; Key Project of
   the Science and Technology Department of Sichuan Province [2022YFH0100];
   1<SUP>.</SUP>3 5 Project for Disciplines of Excellence, West China
   Hospital, Sichuan University [ZYYC21012]; Fundamental Research Funds for
   the Central Universities, China [20822041E4084]
FX This work was supported by the National Natural Science Foundation of
   China (NO. 82171829), the Key Project of the Science and Technology
   Department of Sichuan Province (NO. 2022YFH0100), the
   1<SUP>.</SUP>3<SUP>.</SUP>5 Project for Disciplines of Excellence, West
   China Hospital, Sichuan University (NO. ZYYC21012), and the Fundamental
   Research Funds for the Central Universities, China (20822041E4084). DZ
   sincerely wants to commemorate Dr. SangA Park, who passed away suddenly
   on January 22, 2018.
CR Abdelmalek MF, 2010, HEPATOLOGY, V51, P1961, DOI 10.1002/hep.23535
   Afshin A, 2017, NEW ENGL J MED, V377, P1496, DOI 10.1056/NEJMc1710026
   Al Bander Z, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17207618
   Anthoney N, 2018, DEVELOPMENT, V145, DOI 10.1242/dev.156018
   Bergheim I, 2008, J HEPATOL, V48, P983, DOI 10.1016/j.jhep.2008.01.035
   Boden G, 2011, CURR OPIN ENDOCRINOL, V18, P139, DOI 10.1097/MED.0b013e3283444b09
   Brand A, 2016, CELL METAB, V24, P657, DOI 10.1016/j.cmet.2016.08.011
   Bray GA, 2010, CURR OPIN LIPIDOL, V21, P51, DOI 10.1097/MOL.0b013e3283346ca2
   Bu PC, 2018, CELL METAB, V27, P1249, DOI 10.1016/j.cmet.2018.04.003
   Caliceti C, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040395
   Castro MC, 2015, LIFE SCI, V137, P1, DOI 10.1016/j.lfs.2015.07.010
   Certo M, 2021, NAT REV IMMUNOL, V21, P151, DOI 10.1038/s41577-020-0406-2
   Chang PV, 2014, P NATL ACAD SCI USA, V111, P2247, DOI 10.1073/pnas.1322269111
   Chen LY, 2013, FOOD CHEM TOXICOL, V52, P28, DOI 10.1016/j.fct.2012.10.037
   Chen WL, 2016, CANCER CELL, V30, P779, DOI 10.1016/j.ccell.2016.09.006
   Cheon SY, 2021, J MOL MED, V99, P1497, DOI 10.1007/s00109-021-02117-8
   Chiang SK, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20010039
   Cho YE, 2021, HEPATOLOGY, V73, P2180, DOI 10.1002/hep.30652
   Choi YJ, 2014, FASEB J, V28, P3197, DOI 10.1096/fj.13-247148
   Coleman OI, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.02825
   den Besten G, 2013, AM J PHYSIOL-GASTR L, V305, pG900, DOI 10.1152/ajpgi.00265.2013
   DeNardo DG, 2007, BREAST CANCER RES, V9, DOI 10.1186/bcr1746
   DiNicolantonio JJ, 2018, PROG CARDIOVASC DIS, V61, P3, DOI 10.1016/j.pcad.2017.12.001
   Do MH, 2018, NUTRIENTS, V10, DOI 10.3390/nu10060761
   Doridot L, 2021, NUTRIENTS, V13, DOI 10.3390/nu13103642
   Düvel K, 2010, MOL CELL, V39, P171, DOI 10.1016/j.molcel.2010.06.022
   Durán RV, 2012, MOL CELL, V47, P349, DOI 10.1016/j.molcel.2012.05.043
   Feng J, 2017, ONCOGENE, V36, P5829, DOI 10.1038/onc.2017.188
   Fitzgerald KA, 2020, CELL, V180, P1044, DOI 10.1016/j.cell.2020.02.041
   FROESCH ER, 1972, ACTA MED SCAND, P37
   Gibbons GF, 2000, BBA-MOL CELL BIOL L, V1483, P37, DOI 10.1016/S1388-1981(99)00182-1
   Ginhoux F, 2014, NAT REV IMMUNOL, V14, P392, DOI 10.1038/nri3671
   Goncalves MD, 2019, SCIENCE, V363, P1345, DOI 10.1126/science.aat8515
   Haas R, 2015, PLOS BIOL, V13, DOI 10.1371/journal.pbio.1002202
   Hannou SA, 2018, J CLIN INVEST, V128, P545, DOI 10.1172/JCI96702
   Hansen IS, 2019, INFLAMM RES, V68, P775, DOI 10.1007/s00011-019-01261-9
   HEINZ F, 1968, J CLIN INVEST, V47, P1826, DOI 10.1172/JCI105872
   Hoque R, 2014, GASTROENTEROLOGY, V146, P1763, DOI 10.1053/j.gastro.2014.03.014
   Hudson BI, 2018, ANNU REV MED, V69, P349, DOI 10.1146/annurev-med-041316-085215
   Ibrahimi A, 2002, CURR OPIN CLIN NUTR, V5, P139, DOI 10.1097/00075197-200203000-00004
   Inoguchi T, 2003, J AM SOC NEPHROL, V14, pS227, DOI 10.1097/01.ASN.0000077407.90309.65
   Ishimoto T, 2012, P NATL ACAD SCI USA, V109, P4320, DOI 10.1073/pnas.1119908109
   Jaiswal N, 2019, CLIN EXP IMMUNOL, V197, P237, DOI 10.1111/cei.13299
   Jang C, 2020, NAT METAB, V2, P586, DOI 10.1038/s42255-020-0222-9
   Jang C, 2018, CELL METAB, V27, P351, DOI 10.1016/j.cmet.2017.12.016
   Jegatheesan P, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030230
   Jensen T, 2018, J HEPATOL, V68, P1063, DOI 10.1016/j.jhep.2018.01.019
   Jeong S, 2021, CELL METAB, V33, P145, DOI 10.1016/j.cmet.2020.12.005
   Jia GH, 2014, CURR HYPERTENS REP, V16, DOI 10.1007/s11906-014-0434-z
   Jiang HF, 2021, J GENET GENOMICS, V48, P531, DOI 10.1016/j.jgg.2021.06.006
   Jin R, 2014, INT J HEPATOL, V2014, DOI 10.1155/2014/560620
   Jing YH, 2010, DIABETES-METAB RES, V26, P212, DOI 10.1002/dmrr.1076
   Jones N, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-21461-4
   Joosten LAB, 2020, NAT REV RHEUMATOL, V16, P75, DOI 10.1038/s41584-019-0334-3
   Kaneko C, 2017, BBA-GEN SUBJECTS, V1861, P559, DOI 10.1016/j.bbagen.2016.11.042
   Kim J, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-19263-1
   Konkel JE, 2017, IMMUNITY, V46, P660, DOI 10.1016/j.immuni.2017.03.015
   Krause N, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9122635
   Kuehm LM, 2021, CANCER IMMUNOL RES, V9, P227, DOI 10.1158/2326-6066.CIR-20-0396
   Kuhn KA, 2018, MUCOSAL IMMUNOL, V11, P357, DOI 10.1038/mi.2017.55
   Lambertz J, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.01159
   Lanaspa MA, 2012, J BIOL CHEM, V287, P40732, DOI 10.1074/jbc.M112.399899
   Leite TC, 2011, FEBS LETT, V585, P92, DOI 10.1016/j.febslet.2010.11.009
   Li JM, 2019, MICROBIOME, V7, DOI 10.1186/s40168-019-0713-7
   Linke M, 2017, FEBS LETT, V591, P3089, DOI 10.1002/1873-3468.12711
   Liu L, 2020, CELL METAB, V32, P605, DOI 10.1016/j.cmet.2020.07.018
   Loftus RM, 2016, J BIOL CHEM, V291, P1, DOI 10.1074/jbc.R115.693903
   Lu Y, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.00072
   MAENPAA PH, 1968, SCIENCE, V161, P1253, DOI 10.1126/science.161.3847.1253
   Maersk M, 2012, AM J CLIN NUTR, V95, P283, DOI 10.3945/ajcn.111.022533
   Mirtschink P, 2018, EUR HEART J, V39, P2497, DOI 10.1093/eurheartj/ehx518
   Miura K, 2017, J OBES METAB SYNDR, V26, P86, DOI 10.7570/jomes.2017.26.2.86
   Morgan ME, 2014, MUCOSAL IMMUNOL, V7, P1266, DOI 10.1038/mi.2014.16
   Muriel P, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22136969
   Nakagawa T, 2006, AM J PHYSIOL-RENAL, V290, pF625, DOI 10.1152/ajprenal.00140.2005
   Nergiz-Unal R, 2020, NUTRITION, V79-80, DOI 10.1016/j.nut.2020.110954
   Novelle MG, 2021, ISCIENCE, V24, DOI 10.1016/j.isci.2021.102071
   NOZAKI S, 1995, J CLIN INVEST, V96, P1859, DOI 10.1172/JCI118231
   Venegas DP, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.00277
   Park YM, 2009, J CLIN INVEST, V119, P136, DOI 10.1172/JCI35535
   Pasqualli T, 2020, J FOOD BIOCHEM, V44, DOI 10.1111/jfbc.13496
   Pearce EL, 2013, IMMUNITY, V38, P633, DOI 10.1016/j.immuni.2013.04.005
   Perez-Pozo SE, 2010, INT J OBESITY, V34, P454, DOI 10.1038/ijo.2009.259
   Porto ML, 2015, TOXICOL IN VITRO, V29, P1977, DOI 10.1016/j.tiv.2015.08.006
   Pucino V, 2018, EXPERT OPIN THER TAR, V22, P735, DOI 10.1080/14728222.2018.1511706
   Pucino V, 2017, EUR J IMMUNOL, V47, P14, DOI 10.1002/eji.201646477
   Rai AK, 2019, J NUTR BIOCHEM, V71, P35, DOI 10.1016/j.jnutbio.2019.05.016
   Roland CL, 2014, CANCER RES, V74, P5301, DOI 10.1158/0008-5472.CAN-14-0319
   Rosset R, 2017, AM J CLIN NUTR, V105, P609, DOI 10.3945/ajcn.116.138214
   Rouhiainen Ari, 2013, Methods Mol Biol, V963, P239, DOI 10.1007/978-1-62703-230-8_15
   Ruggiero C, 2006, EUR HEART J, V27, P1174, DOI 10.1093/eurheatj/ehi879
   Rysman E, 2010, CANCER RES, V70, P8117, DOI 10.1158/0008-5472.CAN-09-3871
   Samuvel DJ, 2009, J IMMUNOL, V182, P2476, DOI 10.4049/jimmunol.0802059
   Sanchez-Lozada LG, 2019, J BIOL CHEM, V294, P4272, DOI 10.1074/jbc.RA118.006158
   Schröder M, 2005, MUTAT RES-FUND MOL M, V569, P29, DOI 10.1016/j.mrfmmm.2004.06.056
   Sellmann C, 2015, J NUTR BIOCHEM, V26, P1183, DOI 10.1016/j.jnutbio.2015.05.011
   Shi H, 2006, J CLIN INVEST, V116, P3015, DOI 10.1172/JCI28898
   Shomali N, 2021, BIOTECHNOL APPL BIOC, V68, P404, DOI 10.1002/bab.1938
   Sicard JF, 2017, FRONT CELL INFECT MI, V7, DOI 10.3389/fcimb.2017.00387
   Smith PM, 2013, SCIENCE, V341, P569, DOI 10.1126/science.1241165
   Spruss A, 2009, HEPATOLOGY, V50, P1094, DOI 10.1002/hep.23122
   Stanhope KL, 2011, J CLIN ENDOCR METAB, V96, pE1596, DOI 10.1210/jc.2011-1251
   Stelzner K, 2016, EUR J IMMUNOL, V46, P2043, DOI 10.1002/eji.201546263
   Su CH, 2018, BIOCHEM BIOPH RES CO, V500, P462, DOI 10.1016/j.bbrc.2018.04.103
   Sun MM, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-05901-2
   Sun MM, 2017, J GASTROENTEROL, V52, P1, DOI 10.1007/s00535-016-1242-9
   Tan JY, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201801402
   Tan R, 2021, FRONT CELL INFECT MI, V11, DOI 10.3389/fcimb.2021.654074
   Taskinen MR, 2019, NUTRIENTS, V11, DOI 10.3390/nu11091987
   Taylor SR, 2021, NATURE, V597, P263, DOI [10.1038/s41586-021-03827-2, https://doi.org/10.1038/d41586-021-02195-1]
   Tian KM, 2020, CURR ATHEROSCLER REP, V22, DOI 10.1007/s11883-020-00870-8
   Todoric J, 2020, NAT METAB, V2, P1034, DOI 10.1038/s42255-020-0261-2
   Varma V, 2015, METABOLITES, V5, P364, DOI 10.3390/metabo5020364
   Volynets V, 2017, J NUTR, V147, P770, DOI 10.3945/jn.116.242859
   Morano AEV, 2020, J CELL PHYSIOL, V235, P3169, DOI 10.1002/jcp.29228
   Wagnerberger S, 2012, BRIT J NUTR, V107, P1727, DOI 10.1017/S0007114511004983
   Walker BR, 2006, ANN NY ACAD SCI, V1083, P165, DOI 10.1196/annals.1367.012
   Wang W, 2015, FREE RADICAL BIO MED, V83, P214, DOI 10.1016/j.freeradbiomed.2015.02.029
   Wang Y, 2020, MEDIAT INFLAMM, V2020, DOI 10.1155/2020/6672636
   Weng YY, 2018, CELL DEATH DISCOV, V4, DOI 10.1038/s41420-018-0038-5
   Wu W, 2017, MUCOSAL IMMUNOL, V10, P946, DOI 10.1038/mi.2016.114
   Zhang DM, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040335
   Zhang WL, 2017, BIOTECHNOL ADV, V35, P267, DOI 10.1016/j.biotechadv.2017.01.004
   Zhang Y, 2016, BIOCHEM BIOPH RES CO, V473, P388, DOI 10.1016/j.bbrc.2016.02.111
   Zhao S, 2020, NATURE, V579, P586, DOI 10.1038/s41586-020-2101-7
   Zhou GY, 2016, BIOMED PHARMACOTHER, V81, P318, DOI 10.1016/j.biopha.2016.04.013
NR 126
TC 19
Z9 21
U1 6
U2 35
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0198-8859
EI 1879-1166
J9 HUM IMMUNOL
JI Hum. Immunol.
PD JUN
PY 2022
VL 83
IS 6
BP 538
EP 546
DI 10.1016/j.humimm.2022.03.007
EA MAY 2022
PG 9
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 1T5TW
UT WOS:000804791600010
PM 35414462
DA 2025-06-11
ER

PT J
AU Martínez, AD
   Ruelas, L
   Granger, DA
AF Martinez, Airin D.
   Ruelas, Lillian
   Granger, Douglas A.
TI Household fear of deportation in Mexican-origin families: Relation to
   body mass index percentiles and salivary uric acid
SO AMERICAN JOURNAL OF HUMAN BIOLOGY
LA English
DT Article
ID NUTRITION EXAMINATION SURVEY; 3RD NATIONAL-HEALTH; METABOLIC SYNDROME;
   FOOD INSECURITY; UNITED-STATES; CHOLESTEROL VARIABILITY; IMMIGRATION
   POLICIES; PSYCHOSOCIAL STRESS; LATINO IMMIGRANTS; PUBLIC-HEALTH
AB ObjectiveFear of deportation (FOD) is a prevalent concern among mixed-status families. Yet, our understanding of how FOD shapes human health and development is in its infancy. To begin to address this knowledge gap, we examined the relationship between household FOD, body mass index (BMI) percentiles and salivary uric acid (sUA), a biomarker related to oxidative stress/hypertension/metabolic syndrome, among 111 individuals living in Mexican-origin families.
   MethodsParticipants were 65 children (2 months-17 years, 49% female) and 46 adults (20-58 years, 71% female) living in 30 Mexican-origin families with at least one immigrant parent in Phoenix, AZ. We recruited families using cluster probability sampling of 30 randomly selected census tracts with a high proportion of Hispanic/Latino immigrants. The head of household completed a survey containing demographic, FOD, and psychosocial measures. All family members provided saliva (later assayed for sUA) and anthropometric measures. Relationships between household FOD, BMI percentile, and sUA levels were estimated using multilevel models.
   ResultsHigher levels of household FOD were associated with lower BMI percentiles and lower sUA levels between families, after controlling for social support and socioeconomic proxies.
   ConclusionKey features of the social ecology in which mixed-status families are embedded are associated with individual differences in biological processes linked to increased risk for chronic disease.
C1 [Martinez, Airin D.; Ruelas, Lillian] Arizona State Univ, Sch Transborder Studies, Tempe, AZ USA.
   [Martinez, Airin D.] Yale Univ, Ethn Race & Migrat Program & Amer Studies, New Haven, CT USA.
   [Granger, Douglas A.] Univ Calif Irvine, Inst Interdisciplinary Salivary Biosci Res, Irvine, CA USA.
   [Granger, Douglas A.] Johns Hopkins Univ, Sch Med, Sch Nursing, Baltimore, MD USA.
   [Granger, Douglas A.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA.
   [Granger, Douglas A.] Univ Nebraska, Saliva Biosci Lab, Lincoln, NE USA.
   [Granger, Douglas A.] Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA.
C3 Arizona State University; Arizona State University-Tempe; Yale
   University; University of California System; University of California
   Irvine; Johns Hopkins University; Johns Hopkins University; Johns
   Hopkins Bloomberg School of Public Health; University of Nebraska
   System; University of Nebraska Lincoln; University of Nebraska System;
   University of Nebraska Lincoln
RP Martínez, AD (corresponding author), Arizona State Univ, Sch Transborder Studies, Coll Liberal Arts & Sci, Tempe, AZ 85782 USA.
EM admarti1@mainex1.asu.edu
FU ASU College of Liberal Arts and Sciences Seed Funding Mechanism; Program
   for Transborder Communities seed grant
FX This project received funding from the ASU College of Liberal Arts and
   Sciences Seed Funding Mechanism and the Program for Transborder
   Communities seed grant.
CR ANDERSEN BL, 1994, AM PSYCHOL, V49, P389, DOI 10.1037/0003-066X.49.5.389
   ANDERSON N B, 1991, Ethnicity and Disease, V1, P154
   Aranda E, 2015, SOCIOL RACE ETHNIC, V1, P88, DOI 10.1177/2332649214551097
   Arbona C, 2010, HISPANIC J BEHAV SCI, V32, P362, DOI 10.1177/0739986310373210
   Aschbacher K, 2013, PSYCHONEUROENDOCRINO, V38, P1698, DOI 10.1016/j.psyneuen.2013.02.004
   Baldree L. A., 1997, PEDIATR CLIN N AM, V37, P391
   Barrera M, 1981, SOCIAL NETWORKS SOCI, P69
   Becerra D., 2013, RACE SOC PROBL, V5, P65, DOI [DOI 10.1007/S12552-012-9084-4, https://doi.org/10.1007/s12552-012-9084-4]
   Bohnert ASB, 2009, ADDICTION, V104, P1210, DOI 10.1111/j.1360-0443.2009.02615.x
   Candelario G.E.B., 2007, Companion to Latina/o Studies, P337
   Cavazos-Rehg PA, 2007, J NATL MED ASSOC, V99, P1126
   Choi HK, 2005, ARTHRITIS RHEUM-US, V52, P283, DOI 10.1002/art.20761
   Choi JWJ, 2008, ARTHRIT RHEUM-ARTHR, V59, P109, DOI 10.1002/art.23245
   Clark R., 2012, RACE ETHNICITY HLTH, V2nd, P79
   Cook S, 2003, ARCH PEDIAT ADOL MED, V157, P821, DOI 10.1001/archpedi.157.8.821
   De Genova NP, 2002, ANNU REV ANTHROPOL, V31, P419, DOI 10.1146/annurev.anthro.31.040402.085432
   de Oliveira EP, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-11
   de Oliveira EP, 2012, DIABETOL METAB SYNDR, V4, DOI 10.1186/1758-5996-4-12
   Dressler WW, 2005, ANNU REV ANTHROPOL, V34, P231, DOI 10.1146/annurev.anthro.34.081804.120505
   Enders C.K., 2010, APPL MISSING DATA
   Epel ES, 2009, HORM-INT J ENDOCRINO, V8, P7, DOI 10.14310/horm.2002.1217
   Flegal KM, 2005, JAMA-J AM MED ASSOC, V293, P1861, DOI 10.1001/jama.293.15.1861
   Ford ES, 2007, CIRCULATION, V115, P2526, DOI 10.1161/CIRCULATIONAHA.106.657627
   Goodman AM, 2016, NEUROSCIENCE, V339, P396, DOI 10.1016/j.neuroscience.2016.10.002
   GORODISCHER R, 1994, THER DRUG MONIT, V16, P437, DOI 10.1097/00007691-199410000-00001
   Granger DA, 2007, PHYSIOL BEHAV, V92, P583, DOI 10.1016/j.physbeh.2007.05.004
   Granger DA, 2012, J ADOLESCENCE, V35, P1081, DOI 10.1016/j.adolescence.2012.01.005
   Hardy LJ, 2012, AM J PUBLIC HEALTH, V102, P1250, DOI 10.2105/AJPH.2011.300541
   Harrell CJP, 2011, DU BOIS REV, V8, P143, DOI 10.1017/S1742058X11000178
   Holmes LM, 2012, HEALTH PLACE, V18, P683, DOI 10.1016/j.healthplace.2011.11.006
   Ishizaka Y, 2014, NEPHRON CLIN PRACT, V128, P49, DOI 10.1159/000362456
   Jones DP, 2008, PEDIATR RES, V64, P556, DOI 10.1203/PDR.0b013e318183fd7c
   Juraschek SP, 2013, ARTHRIT CARE RES, V65, P127, DOI 10.1002/acr.21791
   Kalil A, 2008, NEW DIR CHILD ADOLES, V121, P43, DOI 10.1002/cd.222
   KASL SV, 1975, PSYCHOSOM MED, V37, P106, DOI 10.1097/00006842-197503000-00002
   Kaur J, 2015, J ACAD NUTR DIET, V115, P751, DOI 10.1016/j.jand.2015.01.003
   Kesebir S, 2014, J AFFECT DISORDERS, V165, P131, DOI 10.1016/j.jad.2014.04.053
   Krieger N, 2012, AM J PUBLIC HEALTH, V102, P936, DOI 10.2105/AJPH.2011.300544
   Kuchan MJ, 2000, J AM COLL NUTR, V19, P16, DOI 10.1080/07315724.2000.10718909
   Kuczmarski R J, 2000, Adv Data, P1
   Landale NS, 2015, J HEALTH SOC BEHAV, V56, P2, DOI 10.1177/0022146514567896
   Lazarus R. S., 1984, Stress, appraisal, and coping, DOI [10.1007/978-3-030-39903-0_215, DOI 10.1007/978-1-4419-1005-9_215]
   Lorenzi TM, 2010, J AFFECT DISORDERS, V121, P161, DOI 10.1016/j.jad.2009.05.023
   Lyngdoh T, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076336
   Macht M, 2008, APPETITE, V50, P1, DOI 10.1016/j.appet.2007.07.002
   Magana Lisa., 2013, Latino Politics and Arizona's Immigration Law SB 1070
   Martínez AD, 2017, DEV PSYCHOBIOL, V59, P225, DOI 10.1002/dev.21492
   Martínez AD, 2014, GLOBALIZATION HEALTH, V10, DOI 10.1186/1744-8603-10-57
   Martinez O, 2015, J IMMIGR MINOR HEALT, V17, P947, DOI 10.1007/s10903-013-9968-4
   Massey D., 2015, Hispanics in America: A report card on poverty, mobility, and assimilation, P3
   McClure HH, 2010, AM J HUM BIOL, V22, P421, DOI 10.1002/ajhb.21002
   McClure HH., 2013, Advances in Anthropology, V03, DOI [DOI 10.4236/AA.2013.32015, DOI 10.1016/j.psyneuen.2015.12.016]
   Mellen PB, 2006, HYPERTENSION, V48, P1037, DOI 10.1161/01.HYP.0000249768.26560.66
   Moriwaki Y., 2014, J BIOEQUIVALENCE BIO, V6, P10, DOI [DOI 10.4172/JBB.1000173, 10.4172/jbb.1000173]
   MUELLER EF, 1970, PSYCHOL BULL, V73, P238, DOI 10.1037/h0028961
   Núñez GG, 2007, HUM ORGAN, V66, P354, DOI 10.17730/humo.66.4.v32mp32167k8l705
   Ogden CL, 2012, JAMA-J AM MED ASSOC, V307, P483, DOI [10.1001/jama.2012.39, 10.1001/jama.2012.40]
   Quiroga SS, 2014, AM BEHAV SCI, V58, P1723, DOI 10.1177/0002764214537270
   RAHE RH, 1967, J AMER MED ASSOC, V202, P1052, DOI 10.1001/jama.202.11.1052
   RAHE RH, 1968, J AMER MED ASSOC, V206, P2875, DOI 10.1001/jama.206.13.2875
   Read-Wahidi MR, 2017, MED ANTHROPOL Q, V31, P572, DOI 10.1111/maq.12372
   Rhodes SD, 2015, AM J PUBLIC HEALTH, V105, P329, DOI 10.2105/AJPH.2014.302218
   Rodriguez M.A., 2015, CREATING CONDITIONS
   Salas LM, 2013, J COMMUNITY PSYCHOL, V41, P1005, DOI 10.1002/jcop.21589
   Salimetrics, SAL UR AC ENZ ASS KI
   Selye H., 1976, The Stress of Life, VRev
   Sharkey J., 2012, INFLUENCE COMMUNITY
   Sun H., 2015, PLOS ONE, V10
   Suro RobertoMarcelo M Suarez-Orozco Stephanie Canizales., 2015, Removing Insecurity: How American Children Will Benefit From President Obama's Executive Action on Immigration
   Sutin AR, 2014, BIOL PSYCHIAT, V75, P31, DOI 10.1016/j.biopsych.2013.02.024
   Theodore N., 2013, Insecure Communities: Latino Perceptions of Police Involvement in Immigration Enforcement
   THOMAS PD, 1985, AM J PSYCHIAT, V142, P735
   Van Hook J, 2006, SOC SCI RES, V35, P228, DOI 10.1016/j.ssresearch.2004.09.001
   Vargas ED, 2017, J HEALTH POLIT POLIC, V42, P459, DOI 10.1215/03616878-3802940
   Viazzi F., 2015, ITALIAN J PEDIAT, V41, P72
   Wang JY, 2012, J PEDIATR-US, V161, P753, DOI 10.1016/j.jpeds.2012.03.036
   Yoshikawa H., 2013, Unauthorized immigrant parents and their children's development: A summary of the evidence
   Yoshikawa H, 2008, NEW DIR CHILD ADOLES, V121, P63, DOI 10.1002/cd.223
   Zhao JX, 2015, CLIN CHIM ACTA, V450, P115, DOI 10.1016/j.cca.2015.08.005
   ZIR LM, 1973, ARCH INTERN MED, V132, P808, DOI 10.1001/archinte.132.6.808
NR 80
TC 20
Z9 20
U1 1
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1042-0533
EI 1520-6300
J9 AM J HUM BIOL
JI Am. J. Hum. Biol.
PD NOV-DEC
PY 2017
VL 29
IS 6
AR e23044
DI 10.1002/ajhb.23044
PG 14
WC Anthropology; Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Anthropology; Life Sciences & Biomedicine - Other Topics
GA FM6VO
UT WOS:000415199300014
PM 28726338
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Johnson, RJ
   Lanaspa, MA
   Sanchez-Lozada, LG
   Tolan, D
   Nakagawa, T
   Ishimoto, T
   Andres-Hernando, A
   Rodriguez-Iturbe, B
   Stenvinkel, P
AF Johnson, Richard J.
   Lanaspa, Miguel A.
   Sanchez-Lozada, L. Gabriela
   Tolan, Dean
   Nakagawa, Takahiko
   Ishimoto, Takuji
   Andres-Hernando, Ana
   Rodriguez-Iturbe, Bernardo
   Stenvinkel, Peter
TI The fructose survival hypothesis for obesity
SO PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
LA English
DT Review
DE obesity; fructose; metabolic syndrome; sugar; diabetes; uric acid
ID URIC-ACID; METABOLIC SYNDROME; MEAT INTAKE; GLOMERULAR HYPERTENSION;
   OXIDATIVE STRESS; DIETARY FRUCTOSE; FATTY LIVER; MITOCHONDRIAL
   DYSFUNCTION; DIABETES-MELLITUS; ENERGY-METABOLISM
AB The fructose survival hypothesis proposes that obesity and metabolic disorders may have developed from over-stimulation of an evolutionary-based biologic response (survival switch) that aims to protect animals in advance of crisis. The response is characterized by hunger, thirst, foraging, weight gain, fat accumulation, insulin resistance, systemic inflammation and increased blood pressure. The process is initiated by the ingestion of fructose or by stimulating endogenous fructose production via the polyol pathway. Unlike other nutrients, fructose reduces the active energy (adenosine triphosphate) in the cell, while blocking its regeneration from fat stores. This is mediated by intracellular uric acid, mitochondrial oxidative stress, the inhibition of AMP kinase and stimulation of vasopressin. Mitochondrial oxidative phosphorylation is suppressed, and glycolysis stimulated. While this response is aimed to be modest and short-lived, the response in humans is exaggerated due to gain of 'thrifty genes' coupled with a western diet rich in foods that contain or generate fructose. We propose excessive fructose metabolism not only explains obesity but the epidemics of diabetes, hypertension, non-alcoholic fatty liver disease, obesity-associated cancers, vascular and Alzheimer's dementia, and even ageing. Moreover, the hypothesis unites current hypotheses on obesity. Reducing activation and/or blocking this pathway and stimulating mitochondrial regeneration may benefit health-span.This article is part of a discussion meeting issue 'Causes of obesity: theories, conjectures and evidence (Part I)'.
C1 [Johnson, Richard J.; Lanaspa, Miguel A.; Andres-Hernando, Ana] Univ Colorado, Anschutz Med Ctr, Dept Med, Aurora, CO 80016 USA.
   [Sanchez-Lozada, L. Gabriela] Inst Nacl Cardiol Ignacio Chavez, Dept Cardiorenal Physiopathol, Mexico City 14080, Mexico.
   [Tolan, Dean] Boston Univ, Biol Dept, Boston, MA 02215 USA.
   [Nakagawa, Takahiko] Rakuwakai Otowa Hosp, Dept Nephrol, Kyoto 6078062, Japan.
   [Ishimoto, Takuji] Aichi Med Univ, Dept Nephrol & Rheumatol, Nagakute, Aichi 4801103, Japan.
   [Rodriguez-Iturbe, Bernardo] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Nephrol & Mineral Metab, Mexico City 14080, Mexico.
   [Stenvinkel, Peter] Karolinska Inst, Dept Renal Med, S-17177 Stockholm, Sweden.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; National Institute of Cardiology - Mexico; Boston University;
   Aichi Medical University; Instituto Nacional de Ciencias Medicas y
   Nutricion Salvador Zubiran - Mexico; Karolinska Institutet
RP Johnson, RJ (corresponding author), Univ Colorado, Anschutz Med Ctr, Dept Med, Aurora, CO 80016 USA.
EM richard.johnson@cuanschutz.edu
RI Sanchez-Lozada, Laura/AAS-2104-2021; Rodriguez-Iturbe,
   Bernardo/KFX-2910-2024; Lanaspa, Miguel/AAO-4971-2020; Ishimoto,
   Takuji/M-4873-2014
OI Tolan, Dean/0000-0002-0598-7241; Andres-Hernando,
   Ana/0000-0002-0676-0188; Johnson, Richard/0000-0003-3312-8193
FU NIH [R01 DK121496, U01 AA027997]
FX Support for this study comes from NIH grants R01 DK121496 (R.J.J. and
   M.A.L.) and U01 AA027997 (R.J.J.).
CR Abdelmalek MF, 2012, HEPATOLOGY, V56, P952, DOI 10.1002/hep.25741
   Abdelmalek MF, 2010, HEPATOLOGY, V51, P1961, DOI 10.1002/hep.23535
   Abegglen LM, 2015, JAMA-J AM MED ASSOC, V314, P1850, DOI 10.1001/jama.2015.13134
   Agrawal R, 2016, J CEREBR BLOOD F MET, V36, P941, DOI 10.1177/0271678X15606719
   Ahsan Ejaz A., Integratice Med. Nephrol. Androl., V9, P8, DOI [10.4103/2773-0387, DOI 10.4103/2773-0387, DOI 10.4103/2773-0387.348714]
   Al-Ozairi E, 2020, J DIABETES, V12, P197, DOI 10.1111/1753-0407.12984
   Amani S, 2020, CURR DIABETES REV, V16, P962, DOI 10.2174/1389450121666200204115751
   Andres-Hernando A, 2021, NAT METAB, V3, P1189, DOI 10.1038/s42255-021-00454-z
   Andres-Hernando A, 2021, JCI INSIGHT, V6, DOI 10.1172/jci.insight.140848
   Andres-Hernando A, 2020, AM J PHYSIOL-ENDOC M, V319, pE276, DOI 10.1152/ajpendo.00529.2019
   Andres-Hernando A, 2020, CELL METAB, V32, P117, DOI 10.1016/j.cmet.2020.05.012
   Andres-Hernando A, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms14181
   Andrews C, 2021, ROY SOC OPEN SCI, V8, DOI 10.1098/rsos.211099
   Bake T, 2021, J NEUROENDOCRINOL, V33, DOI 10.1111/jne.12997
   Bawden SJ, 2016, CLIN NUTR, V35, P645, DOI 10.1016/j.clnu.2015.04.001
   Benner SA, 2002, SCIENCE, V296, P864, DOI 10.1126/science.1069863
   Benner S, 2017, ACCOUNTS CHEM RES, V50, P498, DOI 10.1021/acs.accounts.6b00496
   Bessesen DH, 2011, PHYSIOL BEHAV, V104, P599, DOI 10.1016/j.physbeh.2011.05.006
   Blundell JE, 2015, PHYSIOL BEHAV, V152, P473, DOI 10.1016/j.physbeh.2015.05.031
   Braga TT, 2017, SCI REP-UK, V7, DOI 10.1038/srep39884
   Bray GA, 2004, AM J CLIN NUTR, V79, P537
   Brown CM, 2008, AM J PHYSIOL-REG I, V294, pR730, DOI 10.1152/ajpregu.00680.2007
   Cabral PD, 2014, HYPERTENSION, V63, pE68, DOI 10.1161/HYPERTENSIONAHA.113.02564
   Cantu-Medellin N, 2013, REDOX BIOL, V1, P353, DOI 10.1016/j.redox.2013.05.002
   Cha SH, 2008, P NATL ACAD SCI USA, V105, P16871, DOI 10.1073/pnas.0809255105
   Chao HH, 2008, ACTA PHARMACOL SIN, V29, P1301, DOI 10.1111/j.1745-7254.2008.00877.x
   Chapman CL, 2019, AM J PHYSIOL-REG I, V316, pR189, DOI 10.1152/ajpregu.00351.2018
   Choi HK, 2004, NEW ENGL J MED, V350, P1093, DOI 10.1056/NEJMoa035700
   Choi YJ, 2014, LAB INVEST, V94, P1114, DOI 10.1038/labinvest.2014.98
   Cicerchi C, 2014, FASEB J, V28, P3339, DOI 10.1096/fj.13-243634
   Cirillo P, 2009, J AM SOC NEPHROL, V20, P545, DOI 10.1681/ASN.2008060576
   CONLEE RK, 1987, ANN NUTR METAB, V31, P126, DOI 10.1159/000177259
   Cox CL, 2012, EUR J CLIN NUTR, V66, P201, DOI 10.1038/ejcn.2011.159
   Cristóbal-Garcia M, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/535686
   Diamond J, 2003, NATURE, V423, P599, DOI 10.1038/423599a
   Enhörning S, 2011, J CLIN ENDOCR METAB, V96, pE1065, DOI 10.1210/jc.2010-2981
   Evershed RP, 2022, NATURE, V608, P336, DOI 10.1038/s41586-022-05010-7
   Feig DI, 2008, JAMA-J AM MED ASSOC, V300, P924, DOI 10.1001/jama.300.8.924
   FEIGELSON M, 1966, J BIOL CHEM, V241, P5819
   Fini MA, 2021, CANCER METAB, V9, DOI 10.1186/s40170-021-00268-3
   Florant GL, 2012, J COMP PHYSIOL B, V182, P451, DOI 10.1007/s00360-011-0630-y
   Flynn TJ, 2015, BMC MUSCULOSKEL DIS, V16, DOI 10.1186/s12891-015-0661-8
   Francey C, 2019, CLIN NUTR ESPEN, V29, P125, DOI 10.1016/j.clnesp.2018.11.008
   FRANK CL, 1994, ECOLOGY, V75, P458, DOI 10.2307/1939549
   Fung TT, 2004, ARCH INTERN MED, V164, P2235, DOI 10.1001/archinte.164.20.2235
   García-Arroyo FE, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22052431
   García-Arroyo FE, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9100601
   GELFAND RA, 1986, METABOLISM, V35, P37, DOI 10.1016/0026-0495(86)90093-4
   Glushakova O, 2008, J AM SOC NEPHROL, V19, P1712, DOI 10.1681/ASN.2007121304
   Goldberg EL, 2017, CELL REP, V18, P2077, DOI 10.1016/j.celrep.2017.02.004
   Goncalves MD, 2019, SCIENCE, V363, P1345, DOI 10.1126/science.aat8515
   Grabek KR, 2019, COMMUN BIOL, V2, DOI 10.1038/s42003-019-0719-5
   Guasch-Ferré M, 2017, AM J CLIN NUTR, V105, P723, DOI 10.3945/ajcn.116.142034
   GUTMAN AB, 1973, AM J MED, V54, P713, DOI 10.1016/0002-9343(73)90057-0
   Hahn K, 2022, MED HYPOTHESES, V160, DOI 10.1016/j.mehy.2022.110796
   Harchaoui KEL, 2009, CURR CARDIOL REV, V5, P216, DOI 10.2174/157340309788970315
   Hayasaki T, 2019, J NUTR BIOCHEM, V71, P54, DOI 10.1016/j.jnutbio.2019.05.017
   Helsley RN, 2023, J HEPATOL, V79, DOI 10.1016/j.jhep.2023.02.010
   Herman MA, 2021, CELL METAB, V33, P2329, DOI 10.1016/j.cmet.2021.09.010
   Hernández-Ríos R, 2013, EXP CLIN ENDOCR DIAB, V121, P535, DOI 10.1055/s-0033-1349144
   Hill CM, 2019, CELL REP, V27, P2934, DOI 10.1016/j.celrep.2019.05.022
   HOYER S, 1992, MOL CHEM NEUROPATHOL, V16, P207, DOI 10.1007/BF03159971
   Hoyer S, 2000, EXP GERONTOL, V35, P1363, DOI 10.1016/S0531-5565(00)00156-X
   Hwang JJ, 2017, JCI INSIGHT, V2, DOI 10.1172/jci.insight.90508
   Ishimoto T, 2013, HEPATOLOGY, V58, P1632, DOI 10.1002/hep.26594
   Ishimoto T, 2013, PEDIATR NEPHROL, V28, P1803, DOI 10.1007/s00467-013-2498-4
   Jansson JO, 2018, P NATL ACAD SCI USA, V115, P427, DOI 10.1073/pnas.1715687114
   Jensen T, 2018, J HEPATOL, V68, P1063, DOI 10.1016/j.jhep.2018.01.019
   Johnson RJ, 2020, J INTERN MED, V287, P252, DOI 10.1111/joim.12993
   Johnson RJ, 2007, AM J CLIN NUTR, V86, P899
   Johnson RJ, 2023, AM J CLIN NUTR, V117, P455, DOI 10.1016/j.ajcnut.2023.01.002
   Johnson RJ, 2022, OBESITY, V30, P1917, DOI 10.1002/oby.23540
   Johnson RJ, 2021, EVOL HUM BEHAV, V42, P194, DOI 10.1016/j.evolhumbehav.2020.09.006
   Johnson RJ, 2021, OBESITY, V29, P11, DOI 10.1002/oby.23028
   Johnson RJ, 2020, FRONT AGING NEUROSCI, V12, DOI 10.3389/fnagi.2020.560865
   Johnson RJ, 2017, ADV NUTR, V8, P412, DOI 10.3945/an.116.014654
   Johnson RJ, 2016, J AM SOC NEPHROL, V27, P2247, DOI 10.1681/ASN.2015121314
   Johnson RJ, 2015, SCI AM, V313, P64, DOI 10.1038/scientificamerican1015-64
   Johnson RJ, 2013, J RHEUMATOL, V40, P1794, DOI 10.3899/jrheum.130531
   Johnson RJ, 2013, OBESITY, V21, P659, DOI 10.1002/oby.20026
   Johnson RJ, 2010, EVOL ANTHROPOL, V19, P250, DOI 10.1002/evan.20266
   Johnson RJ, 2009, ENDOCR REV, V30, P96, DOI 10.1210/er.2008-0033
   Johnson RJ, 2005, SEMIN NEPHROL, V25, P3, DOI 10.1016/j.semnephrol.2004.09.002
   Johnson TA, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.00098
   Kanbay M, 2023, CURR NUTR REP, V12, P181, DOI 10.1007/s13668-023-00452-5
   Kanbay M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13061916
   Kaneko K, 2008, NUCLEOS NUCLEOT NUCL, V27, P628, DOI 10.1080/15257770802138681
   Kanellis J, 2003, HYPERTENSION, V41, P1287, DOI 10.1161/01.HYP.0000072820.07472.3B
   Kang DH, 2005, J AM SOC NEPHROL, V16, P3553, DOI 10.1681/ASN.2005050572
   Kataoka H, 2015, EUR J PHARMACOL, V746, P174, DOI 10.1016/j.ejphar.2014.11.013
   Keesey RE, 2008, APPETITE, V51, P442, DOI 10.1016/j.appet.2008.06.009
   Klauser AS, 2019, JAMA CARDIOL, V4, P1019, DOI 10.1001/jamacardio.2019.3201
   Kleber ME, 2015, J AM SOC NEPHROL, V26, P2831, DOI 10.1681/ASN.2014070660
   Ko J, 2019, FASEB J, V33, P13334, DOI 10.1096/fj.201901148R
   Kono H, 2010, J CLIN INVEST, V120, P1939, DOI 10.1172/JCI40124
   Kratzer JT, 2014, P NATL ACAD SCI USA, V111, P3763, DOI 10.1073/pnas.1320393111
   Kuo CF, 2013, RHEUMATOLOGY, V52, P127, DOI 10.1093/rheumatology/kes223
   Lachapelle MY, 2011, GENETICA, V139, P199, DOI 10.1007/s10709-010-9537-x
   Lanaspa MA, 2018, P NATL ACAD SCI USA, V115, P3138, DOI 10.1073/pnas.1713837115
   Lanaspa MA, 2018, J CLIN INVEST, V128, P2226, DOI 10.1172/JCI94427
   Lanaspa MA, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0123509
   Lanaspa MA, 2014, J AM SOC NEPHROL, V25, P2526, DOI 10.1681/ASN.2013080901
   Lanaspa MA, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3434
   Lanaspa MA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048801
   Lanaspa MA, 2012, J BIOL CHEM, V287, P40732, DOI 10.1074/jbc.M112.399899
   Lanaspa MA, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0047948, 10.1371/journal.pone.0048801]
   Lee JH, 2022, FRONT NUTR, V8, DOI 10.3389/fnut.2021.748847
   Levi B, 1998, J NUTR, V128, P1442, DOI 10.1093/jn/128.9.1442
   Levy O, 2016, AM NAT, V188, P205, DOI 10.1086/687246
   Lew QLJ, 2017, J AM SOC NEPHROL, V28, P304, DOI [10.1681/ASN.2016030248, 10.1681/asn.2016030248]
   Li MT, 2022, NATURE, V610, P722, DOI 10.1038/s41586-022-05266-z
   Li Q, 2021, NAT MED, V27, P1941, DOI 10.1038/s41591-021-01501-8
   Ludwig DS, 2021, AM J CLIN NUTR, V114, P1873, DOI 10.1093/ajcn/nqab270
   Luengo A, 2021, MOL CELL, V81, P691, DOI 10.1016/j.molcel.2020.12.012
   Luukkonen PK, 2018, DIABETES CARE, V41, P1732, DOI 10.2337/dc18-0071
   MAENPAA PH, 1968, SCIENCE, V161, P1253, DOI 10.1126/science.161.3847.1253
   Maier S, 2021, REV ENDOCR METAB DIS, V22, P351, DOI 10.1007/s11154-020-09621-1
   Marton A, 2021, NAT REV NEPHROL, V17, P65, DOI 10.1038/s41581-020-00350-x
   MATTHAEI C, 1976, BEITR PATHOL, V157, P56, DOI 10.1016/S0005-8165(76)80148-5
   Minami S, 2011, MAR BIOTECHNOL, V13, P1140, DOI 10.1007/s10126-011-9377-4
   Mirtschink P, 2018, EUR HEART J, V39, P2497, DOI 10.1093/eurheartj/ehx518
   Mirtschink P, 2016, BBA-MOL CELL RES, V1863, P1822, DOI 10.1016/j.bbamcr.2016.02.011
   Mirtschink P, 2015, NATURE, V522, P444, DOI 10.1038/nature14508
   Monteiro CA, 2013, OBES REV, V14, P21, DOI 10.1111/obr.12107
   MROSOVSKY N, 1980, SCIENCE, V207, P837, DOI 10.1126/science.6928327
   Nair S, 2003, AM J GASTROENTEROL, V98, P466, DOI 10.1016/S0002-9270(02)05889-6
   Nakagawa T, 2006, AM J PHYSIOL-RENAL, V290, pF625, DOI 10.1152/ajprenal.00140.2005
   Nakagawa T, 2023, HYPERTENS RES, V46, P646, DOI 10.1038/s41440-022-01121-w
   Nakagawa T, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.694457
   Nakagawa T, 2020, CANCER METAB, V8, DOI 10.1186/s40170-020-00222-9
   Nakayama T, 2010, AM J PHYSIOL-RENAL, V298, pF712, DOI 10.1152/ajprenal.00433.2009
   Nardi V, 2022, HYPERTENSION, V79, P1814, DOI 10.1161/HYPERTENSIONAHA.122.19247
   Nardocci M, 2021, CAN J PUBLIC HEALTH, V112, P421, DOI 10.17269/s41997-020-00429-9
   NEEL JV, 1962, AM J HUM GENET, V14, P353
   Ng SW, 2012, J ACAD NUTR DIET, V112, P1828, DOI 10.1016/j.jand.2012.07.009
   Ohlsson C, 2020, ECLINICALMEDICINE, V22, DOI 10.1016/j.eclinm.2020.100338
   Ortiz RM, 2001, J EXP BIOL, V204, P1831
   Page KA, 2013, JAMA-J AM MED ASSOC, V309, P63, DOI 10.1001/jama.2012.116975
   Park TJ, 2017, SCIENCE, V356, P305, DOI 10.1126/science.aab3896
   Perez-Pozo SE, 2010, INT J OBESITY, V34, P454, DOI 10.1038/ijo.2009.259
   PERHEENT.J, 1967, LANCET, V2, P528
   Purnell JQ, 2011, DIABETES OBES METAB, V13, P229, DOI 10.1111/j.1463-1326.2010.01340.x
   RAIVIO KO, 1975, METABOLISM, V24, P861, DOI 10.1016/0026-0495(75)90133-X
   Raubenheimer D, 2019, OBESITY, V27, P1225, DOI 10.1002/oby.22531
   Reungjui S, 2007, J AM SOC NEPHROL, V18, P2724, DOI 10.1681/ASN.2007040416
   Ridker PM, 2020, J AM COLL CARDIOL, V76, P1774, DOI 10.1016/j.jacc.2020.08.052
   Rodriguez-Iturbe B, 2022, AM J PHYSIOL-REG I, V322, pR347, DOI 10.1152/ajpregu.00238.2021
   Rodriguez-Iturbe B, 2017, PHYSIOL REV, V97, P1127, DOI 10.1152/physrev.00031.2016
   Roncal-Jimenez CA, 2016, AM J PHYSIOL-RENAL, V311, pF722, DOI 10.1152/ajprenal.00306.2016
   Roncal-Jimenez CA, 2011, METABOLISM, V60, P1259, DOI 10.1016/j.metabol.2011.01.008
   Rorabaugh JM, 2015, NEUROSCIENCE, V301, P213, DOI 10.1016/j.neuroscience.2015.06.015
   Rorabaugh JM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0095019
   RUMESSEN JJ, 1986, GUT, V27, P1161, DOI 10.1136/gut.27.10.1161
   San-Millan I, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.809485
   Sánchez-Lozada LG, 2008, AM J PHYSIOL-RENAL, V295, pF1134, DOI 10.1152/ajprenal.00104.2008
   Sanchez-Lozada LG, 2007, AM J PHYSIOL-RENAL, V292, pF423, DOI 10.1152/ajprenal.00124.2006
   Sanchez-Lozada LG, 2019, J BIOL CHEM, V294, P4272, DOI 10.1074/jbc.RA118.006158
   Sánchez-Lozada LG, 2012, NEPHRON EXP NEPHROL, V121, pE71, DOI 10.1159/000345509
   Sánchez-Lozada LG, 2005, KIDNEY INT, V67, P237, DOI 10.1111/j.1523-1755.2005.00074.x
   Sánchez-Lozada LG, 2003, KIDNEY INT, V64, pS9, DOI 10.1046/j.1523-1755.64.s86.3.x
   Sas KM, 2016, JCI INSIGHT, V1, DOI 10.1172/jci.insight.86976
   Sautin YY, 2007, AM J PHYSIOL-CELL PH, V293, pC584, DOI 10.1152/ajpcell.00600.2006
   Schulte P, 2010, SCIENCE, V327, P1214, DOI 10.1126/science.1177265
   Schulze MB, 2003, DIABETOLOGIA, V46, P1465, DOI 10.1007/s00125-003-1220-7
   Sclafani A, 2022, PHYSIOL BEHAV, V246, DOI 10.1016/j.physbeh.2022.113695
   Seaquist ER, 2001, DIABETES, V50, P2203, DOI 10.2337/diabetes.50.10.2203
   Shapiro A, 2008, AM J PHYSIOL-REG I, V295, pR1370, DOI 10.1152/ajpregu.00195.2008
   Shapiro A, 2011, BRIT J NUTR, V106, P390, DOI 10.1017/S000711451100033X
   Sharma K, 2013, J AM SOC NEPHROL, V24, P1901, DOI 10.1681/ASN.2013020126
   SHEPHARD RJ, 1973, EUR J APPL PHYSIOL O, V32, P3, DOI 10.1007/BF00422425
   Shi C, 2022, NEUROREPORT, V33, P109, DOI 10.1097/WNR.0000000000001762
   SHIMIZU T, 1971, JPN J MED SCI BIOL, V24, P271, DOI 10.7883/yoken1952.24.271
   Softic S, 2019, CELL METAB, V30, P735, DOI 10.1016/j.cmet.2019.09.003
   Softic S, 2018, J CLIN INVEST, V128, P1199, DOI 10.1172/JCI99009
   Softic S, 2017, J CLIN INVEST, V127, P4059, DOI 10.1172/JCI94585
   Soleimani M, 2011, ACTA PHYSIOL, V201, P55, DOI 10.1111/j.1748-1716.2010.02167.x
   Song Y, 2004, DIABETES CARE, V27, P2108, DOI 10.2337/diacare.27.9.2108
   Song ZL, 2017, J NEUROPHYSIOL, V117, P646, DOI 10.1152/jn.00781.2016
   Speakman JR, 2018, J EXP BIOL, V221, DOI 10.1242/jeb.167254
   Stanhope KL, 2009, J CLIN INVEST, V119, P1322, DOI 10.1172/JCI37385
   STAVRIC B, 1976, EXPERIENTIA, V32, P373, DOI 10.1007/BF01940847
   Stenvinkel P, 2020, J INTERN MED, V287, P238, DOI 10.1111/joim.12982
   Stenvinkel P, 2020, NEPHROL DIAL TRANSPL, V35, P2036, DOI 10.1093/ndt/gfz120
   STIRPE F, 1970, LANCET, V2, P1310
   Stookey JD, 2007, EUR J CLIN NUTR, V61, P190, DOI 10.1038/sj.ejcn.1602521
   Stookey JD, 2020, NUTRIENTS, V12, DOI 10.3390/nu12040905
   Sun SZ, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-89
   Sundborn G, 2019, OBESITY, V27, P879, DOI 10.1002/oby.22472
   Szendroedi J, 2009, HEPATOLOGY, V50, P1079, DOI 10.1002/hep.23093
   Tan SX, 2015, J BIOL CHEM, V290, P11337, DOI 10.1074/jbc.M114.623686
   Tapia E, 2013, AM J PHYSIOL-RENAL, V304, pF727, DOI 10.1152/ajprenal.00485.2012
   Taylor SR, 2021, NATURE, V597, P263, DOI [10.1038/s41586-021-03827-2, https://doi.org/10.1038/d41586-021-02195-1]
   Tharabenjasin P, 2014, AM J PHYSIOL-GASTR L, V306, pG1, DOI 10.1152/ajpgi.00263.2013
   USHIJIMA K, 1995, J NUTR, V125, P2156, DOI 10.1093/jn/125.8.2156
   van Dam RM, 2002, DIABETES CARE, V25, P417, DOI 10.2337/diacare.25.3.417
   van der Klaauw AA, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms13055
   VANDENBERGHE G, 1977, BIOCHEM J, V162, P601, DOI 10.1042/bj1620601
   Vellekoop J, 2014, P NATL ACAD SCI USA, V111, P7537, DOI 10.1073/pnas.1319253111
   Vercammen KA, 2020, J ACAD NUTR DIET, V120, P1974, DOI 10.1016/j.jand.2020.07.012
   Wang M, 2020, HEPATOLOGY, V72, P1617, DOI 10.1002/hep.31197
   Wang Y, 2009, INT J OBESITY, V33, P621, DOI 10.1038/ijo.2009.45
   Watanabe S, 2002, HYPERTENSION, V40, P355, DOI 10.1161/01.HYP.0000028589.66335.AA
   Waters DL, 2003, MECH AGEING DEV, V124, P301, DOI 10.1016/S0047-6374(02)00197-5
   WOLF JP, 1992, HORM METAB RES, V24, P379, DOI 10.1055/s-2007-1003340
   Wong SK, 2020, INT J MED SCI, V17, P1625, DOI 10.7150/ijms.47103
   Yang QH, 2014, JAMA INTERN MED, V174, P516, DOI 10.1001/jamainternmed.2013.13563
   Youn JH., 1987, J BIOL CHEM, V262, p11 470, DOI [10.1016/S0021-9258(18)60830-0, DOI 10.1016/S0021-9258(18)60830-0]
   Yu MA, 2010, J HYPERTENS, V28, P1234, DOI 10.1097/HJH.0b013e328337da1d
   Zhao S, 2020, NATURE, V579, P586, DOI 10.1038/s41586-020-2101-7
NR 209
TC 24
Z9 25
U1 2
U2 18
PU ROYAL SOC
PI LONDON
PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND
SN 0962-8436
EI 1471-2970
J9 PHILOS T R SOC B
JI Philos. Trans. R. Soc. B-Biol. Sci.
PD SEP 11
PY 2023
VL 378
IS 1885
AR 20220230
DI 10.1098/rstb.2022.0230
PG 16
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA N1JE3
UT WOS:001034651600009
PM 37482773
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Maneesai, P
   Wattanathorn, J
   Potue, P
   Khamseekaew, J
   Rattanakanokchai, S
   Thukham-Mee, W
   Muchimapura, S
   Pakdeechote, P
AF Maneesai, Putcharawipa
   Wattanathorn, Jintanaporn
   Potue, Prapassorn
   Khamseekaew, Juthamas
   Rattanakanokchai, Siwayu
   Thukham-Mee, Wipawee
   Muchimapura, Supaporn
   Pakdeechote, Poungrat
TI Cardiovascular complications are resolved by tuna protein hydrolysate
   supplementation in rats fed with a high-fat diet
SO SCIENTIFIC REPORTS
LA English
DT Article
ID NF-KAPPA-B; ANGIOTENSIN-II; METABOLIC SYNDROME; CARDIAC-HYPERTROPHY;
   NADPH OXIDASE; ASIATIC ACID; INFLAMMATION; ANTIOXIDANT; METFORMIN;
   EXPRESSION
AB This study is aimed to investigate whether tuna protein hydrolysate (TPH) supplementation could alleviate cardiovascular complications induced by a high-fat diet (HFD) in rats. Rats were fed a HFD for 16 weeks and given TPH (100 mg/kg, 300 mg/kg, or 500 mg/kg) or metformin (100 mg/kg) (n = 8) for the last four weeks. TPH had the following effects: resolved their impaired glucose tolerance, hyperglycemia, dyslipidemia, obesity, and hypertension (p < 0.05); alleviated left ventricular dysfunction and hypertrophy (p < 0.05), and vascular dysfunction and hypertrophy (p < 0.05); adipocyte hypertrophy; increases in circulating leptin and tumor necrosis factor (TNF-& alpha;) were mitigated (p < 0.05); increased renin-angiotensin system (RAS), oxidative stress, and decreased nitric oxide metabolites were modulated (p < 0.05). TPH restored the expression of angiotensin II receptor type 1 (AT1R)/NADPH oxidase 2 (NOX2), endothelial nitric oxide synthase (eNOS), nuclear factor erythroid 2-related factor (Nrf2)/heme oxygenase-1 (HO-1), and peroxisome proliferator-activated receptor & gamma; (PPAR & gamma;)/the nuclear factor kappa B (NF-& kappa;B) protein in cardiovascular tissue (p < 0.05). In metabolic syndrome (MS) rats, metformin and TPH had comparable effects. In conclusion, TPH alleviated cardiovascular complications related to MS. It suppressed RAS, oxidative stress, and inflammation that were associated with modulation of AT1R/NOX2, eNOS, Nrf2/HO-1, and PPAR & gamma;/NF-& kappa;B expression.
C1 [Maneesai, Putcharawipa; Wattanathorn, Jintanaporn; Potue, Prapassorn; Khamseekaew, Juthamas; Thukham-Mee, Wipawee; Muchimapura, Supaporn; Pakdeechote, Poungrat] Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
   [Wattanathorn, Jintanaporn; Thukham-Mee, Wipawee; Muchimapura, Supaporn; Pakdeechote, Poungrat] Khon Kaen Univ, Res Inst Human High Performance & Hlth Promot, Khon Kaen 40002, Thailand.
   [Rattanakanokchai, Siwayu] Khon Kaen Univ, Fac Vet Med, Khon Kaen 40002, Thailand.
C3 Khon Kaen University; Khon Kaen University; Khon Kaen University
RP Pakdeechote, P (corresponding author), Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.; Pakdeechote, P (corresponding author), Khon Kaen Univ, Res Inst Human High Performance & Hlth Promot, Khon Kaen 40002, Thailand.
EM ppoung@kku.ac.th
RI Maneesai, Putcharawipa/AAK-4258-2021
OI Maneesai, Putcharawipa/0000-0003-0889-6211
FU Program Management Unit Competitiveness (PMUC), Thailand
FX This study was supported by the Program Management Unit Competitiveness
   (PMUC), Thailand. We would like to thank Thai Union Group PCL for
   providing tuna protein hydrolysate and its composition data.
CR Bashir KMI, 2020, FOOD CHEM, V323, DOI 10.1016/j.foodchem.2020.126809
   Bendall JK, 2002, CIRCULATION, V105, P293, DOI 10.1161/hc0302.103712
   Byrne JA, 2003, CIRC RES, V93, P802, DOI 10.1161/01.RES.0000099504.30207.F5
   Chaihongsa N, 2021, LIFE SCI, V285, DOI 10.1016/j.lfs.2021.119965
   Chaklader MR, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-84660-5
   Chalamaiah M, 2012, FOOD CHEM, V135, P3020, DOI 10.1016/j.foodchem.2012.06.100
   Chen BH, 2023, LIFE SCI, V312, DOI 10.1016/j.lfs.2022.121092
   DAHLOF B, 1995, J HUM HYPERTENS, V9, pS37
   Dai J, 2018, J RENIN-ANGIO-ALDO S, V19, DOI 10.1177/1470320318778898
   Daskalaki MG, 2021, MAR DRUGS, V19, DOI 10.3390/md19060312
   El-Domiaty HF, 2022, FRONT MED-LAUSANNE, V9, DOI 10.3389/fmed.2022.904756
   Elaziz MA, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-10890-1
   Farhangi MA, 2017, BMC CARDIOVASC DISOR, V17, DOI 10.1186/s12872-017-0597-z
   Feng XH, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.565726
   Feriani A, 2021, ECOTOX ENVIRON SAFE, V222, DOI 10.1016/j.ecoenv.2021.112461
   Guarner-Lans V, 2016, INT J HYPERTENS, V2016, DOI 10.1155/2016/5830192
   Hattori T, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.114.001312
   Hilzendeger AM, 2010, J MOL MED, V88, P899, DOI 10.1007/s00109-010-0649-7
   Je JY, 2009, FOOD RES INT, V42, P1266, DOI 10.1016/j.foodres.2009.06.013
   Jin L, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-15925-1
   Joukar S, 2010, CARDIOVASC TOXICOL, V10, P66, DOI 10.1007/s12012-010-9063-1
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kristinsson HG, 2000, CRIT REV FOOD SCI, V40, P43, DOI 10.1080/10408690091189266
   Lasker S, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-56538-0
   Li XX, 2015, BIOL PHARM BULL, V38, P862, DOI 10.1248/bpb.b14-00828
   Li XX, 2008, J ETHNOPHARMACOL, V119, P259, DOI 10.1016/j.jep.2008.07.019
   Liu F, 2021, EUR J PHARMACOL, V909, DOI 10.1016/j.ejphar.2021.174377
   López-Acosta O, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/5835072
   Lu FJ, 1996, EXPERIENTIA, V52, P141, DOI 10.1007/BF01923359
   Maneesai P, 2017, N-S ARCH PHARMACOL, V390, P1073, DOI 10.1007/s00210-017-1408-x
   Maneesai P, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1100-6
   Martínez-Alvarez O, 2016, FOOD FUNCT, V7, P2066, DOI [10.1039/C5FO01603G, 10.1039/c5fo01603g]
   Meephat S, 2021, FOOD FUNCT, V12, P1469, DOI [10.1039/d0fo02744h, 10.1039/D0FO02744H]
   Mongkonkamthorn N, 2021, J AQUAT FOOD PROD T, V30, P1090, DOI 10.1080/10498850.2021.1974138
   Nakmareong S, 2011, N-S ARCH PHARMACOL, V383, P519, DOI 10.1007/s00210-011-0624-z
   Obafemi TO, 2021, TOXICOL REP, V8, P1419, DOI 10.1016/j.toxrep.2021.07.011
   Obunai K, 2007, MED CLIN N AM, V91, P1169, DOI 10.1016/j.mcna.2007.06.003
   OPARIL S, 1985, J AM COLL CARDIOL, V5, pB57, DOI 10.1016/S0735-1097(85)80528-3
   Pakdeechote P, 2014, NUTRIENTS, V6, P355, DOI 10.3390/nu6010355
   Parolini C, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0097598
   Pei ZH, 2021, METABOLISM, V122, DOI 10.1016/j.metabol.2021.154840
   Pernicova I, 2014, NAT REV ENDOCRINOL, V10, P143, DOI 10.1038/nrendo.2013.256
   Pezeshk S, 2019, PROBIOTICS ANTIMICRO, V11, P1015, DOI 10.1007/s12602-018-9483-y
   Piacenza L, 2022, PHYSIOL REV, V102, P1881, DOI 10.1152/physrev.00005.2022
   Poasakate A, 2022, BIOMED PHARMACOTHER, V146, DOI 10.1016/j.biopha.2021.112601
   Poasakate A, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10020237
   Prasad A, 2004, CIRCULATION, V110, P1507, DOI 10.1161/01.CIR.0000141736.76561.78
   Prasatthong P, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10050769
   Qiao QQ, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.868681
   Ramalingam A, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.01493
   Ranjbar T, 2020, J FOOD BIOCHEM, V44, DOI 10.1111/jfbc.13242
   Renna NF, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0106563
   López YR, 2016, CURR DRUG DELIV, V13, P158, DOI 10.2174/156720181301160314151554
   Song NN, 2011, HEART, V97, DOI 10.1136/heartjnl-2011-300867.182
   Sun XW, 2014, BRIT J NUTR, V112, P477, DOI 10.1017/S0007114514001056
   Sung NY, 2012, FISHERIES SCI, V78, P381, DOI 10.1007/s12562-011-0461-5
   Suo SK, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.957778
   Tran N, 2022, Am J Biomed Sci Res, V15, P153
   Tuzcu Z, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/1583098
   Xia H, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph191912093
   Zayed EA, 2018, J BIOCHEM MOL TOXIC, V32, DOI 10.1002/jbt.22218
   Zhang Q, 2021, J ADV RES, V34, P43, DOI 10.1016/j.jare.2021.06.023
   Zhang Y, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0087343
   Zhou F, 2022, FOOD RES INT, V161, DOI 10.1016/j.foodres.2022.111788
   Zhu CF, 2010, APPL PHYSIOL NUTR ME, V35, P797, DOI 10.1139/H10-075
NR 65
TC 5
Z9 5
U1 1
U2 8
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUL 28
PY 2023
VL 13
IS 1
AR 12280
DI 10.1038/s41598-023-39538-z
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA O1OR5
UT WOS:001041587900034
PM 37507421
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rauchová, H
   Neprasová, B
   Maletínská, L
   Kunes, J
AF Rauchova, Hana
   Neprasova, Barbora
   Maletinska, Lenka
   Kunes, Jaroslav
TI Glutathione Levels and Lipid Oxidative Damage in Selected Organs of
   Obese Koletsky and Lean Spontaneously Hypertensive Rats
SO PHYSIOLOGICAL RESEARCH
LA English
DT Article
DE Thiobarbituric acid-reactive substances; Heart; Renal cortex; Renal
   medulla; Liver
ID SEX-DIFFERENCES; BLOOD-PRESSURE; RECEPTOR; GLUCOSE
AB Koletsky rats, the genetically obese strain of spontaneously hypertensive rats (SHROB), are the well-accepted animal model of human metabolic syndrome. They are characterized by early onset obesity, spontaneous hypertension, hyperinsulinemia, hyperlipidemia, proteinuria and shortened life-span. One of the factors in the pathogenesis of metabolic syndrome is oxidative stress. The aim of the present study was to compare two parameters related to oxidative stress: the levels of the main intracellular antioxidant, reduced glutathione as well as the indirect indicator of lipid peroxidation damage, thiobarbituric acid-reactive substances (TBARS) in heart, renal cortex and medulla and liver in male lean spontaneously hypertensive rats (SHR) and obese Koletsky rats. We did not find any significant differences in these markers in heart and kidneys. However, we found significantly lower glutathione level in Koletsky rat liver compared with SHR (5.03 +/- 0.23 vs. 5.83 +/- 0.14 mu mol/g tissue, respectively). On the contrary, we observed significantly higher TBARS levels in Koletsky rat liver compared with SHR (28.56 +/- 2.15 vs. 21.83 +/- 1.60 nmol/mg protein, respectively). We conclude that the liver is the most sensitive tissue to oxidative damage with the significantly decreased concentration of glutathione and the significantly increased concentration of TBARS in obese Koletsky rats in comparison with lean control SHR.
C1 [Rauchova, Hana; Kunes, Jaroslav] Czech Acad Sci, Inst Physiol, Lab Expt Hypertens, Videnska 1083, CZ-14220 Prague 4, Czech Republic.
   [Neprasova, Barbora; Maletinska, Lenka; Kunes, Jaroslav] Czech Acad Sci, Inst Organ Chem & Biochem, Prague, Czech Republic.
C3 Czech Academy of Sciences; Institute of Physiology of the Czech Academy
   of Sciences; Czech Academy of Sciences; Institute of Organic Chemistry &
   Biochemistry of the Czech Academy of Sciences
RP Rauchová, H (corresponding author), Czech Acad Sci, Inst Physiol, Lab Expt Hypertens, Videnska 1083, CZ-14220 Prague 4, Czech Republic.
EM Hana.Rauchova@fgu.cas.cz
RI Kunes, Jaroslav/B-7079-2012; Rauchova, Hana/B-8288-2012
OI Rauchova, Hana/0000-0002-5807-3662
FU Institute of Physiology , Czech Academy of Sciences [RV0 67985823];
   Institute of Organic Chemistry and Biochemistry , Czech Academy of
   Sciences [RV0 61388963]; Project of National Institute for Research of
   Metabolic and Cardiovascular Diseases (Programme EXCELES) - European
   Union - Next Generation EU [LX22NPO5104]
FX This study was supported by the Institute of Physiology (grant number:
   RV0 67985823) and Institute of Organic Chemistry and Biochemistry (grant
   number: RV0 61388963) , Czech Academy of Sciences and the project of
   National Institute for Research of Metabolic and Cardiovascular Diseases
   (Programme EXCELES, ID Project No. LX22NPO5104) - Funded by the European
   Union - Next Generation EU.
CR de Artiñano AA, 2009, BRIT J NUTR, V102, P1246, DOI 10.1017/S0007114509990729
   Aquilano K, 2014, FRONT PHARMACOL, V5, DOI 10.3389/fphar.2014.00196
   Dong QM, 2018, BIOL SEX DIFFER, V9, DOI 10.1186/s13293-018-0202-x
   ELLMAN GL, 1959, ARCH BIOCHEM BIOPHYS, V82, P70, DOI 10.1016/0003-9861(59)90090-6
   Friedman Jacob E., 1997, American Journal of Physiology, V273, pE1014
   KOLETSKY S, 1975, AM J PATHOL, V80, P129
   KOLETSKY S, 1973, EXP MOL PATHOL, V19, P53, DOI 10.1016/0014-4800(73)90040-3
   Méndez L, 2014, J PROTEOMICS, V106, P246, DOI 10.1016/j.jprot.2014.04.036
   Mikulásková B, 2018, NUTR DIABETES, V8, DOI 10.1038/s41387-017-0015-8
   Molinar-Toribio E, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0104637
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   Rauchová H, 2020, PHYSIOL RES, V69, P245, DOI 10.33549/physiolres.934369
   Rauchová H, 2018, PHYSIOL RES, V67, P307, DOI 10.33549/physiolres.933834
   Rauchová H, 2023, PHYSIOL RES, V72, P167, DOI 10.33549/physiolres.935059
   Takaya K, 1996, NAT GENET, V14, P130, DOI 10.1038/ng1096-130
   Ulrich K, 2019, FREE RADICAL BIO MED, V140, P14, DOI 10.1016/j.freeradbiomed.2019.05.035
   Vokurková M, 2015, PHYSIOL RES, V64, P303, DOI 10.33549/physiolres.933054
NR 17
TC 0
Z9 0
U1 0
U2 1
PU ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
PI PRAGUE 4
PA VIDENSKA 1083, PRAGUE 4 142 20, CZECH REPUBLIC
SN 0862-8408
EI 1802-9973
J9 PHYSIOL RES
JI Physiol. Res.
PD JUN
PY 2024
VL 73
IS 3
BP 481
EP 484
DI 10.33549/physiolres.935319
PG 4
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA YK0V9
UT WOS:001268274800014
PM 39027962
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Barrea, L
   Pugliese, G
   Frias-Toral, E
   El Ghoche, M
   Castellucci, B
   Chapela, SP
   Carignano, MD
   Laudisio, D
   Savastano, S
   Colao, A
   Muscogiuri, G
AF Barrea, Luigi
   Pugliese, Gabriella
   Frias-Toral, Evelyn
   El Ghoche, Marwan
   Castellucci, Bianca
   Pablo Chapela, Sebastian
   de los Angeles Carignano, Maria
   Laudisio, Daniela
   Savastano, Silvia
   Colao, Annamaria
   Muscogiuri, Giovanna
TI Coffee consumption, health benefits and side effects: a narrative review
   and update for dietitians and nutritionists
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Coffee; caffeine; obesity; metabolic syndrome; nutritionist
ID POLYCYCLIC AROMATIC-HYDROCARBONS; DOSE-RESPONSE METAANALYSIS; HEPATIC
   LIPID-METABOLISM; INDUCED OXIDATIVE STRESS; CHLOROGENIC ACID; TEA
   CONSUMPTION; GREEN COFFEE; GEOGRAPHICAL ORIGIN; DIABETES-MELLITUS;
   GLUCOSE-TOLERANCE
AB Coffee is one of the most popular beverages worldwide; however, its impact on health outcomes and adverse effects is not fully understood. The current review aims to establish an update about the benefits of coffee consumption on health outcomes highlighting its side effects, and finally coming up with an attempt to provide some recommendations on its doses. A literature review using the PubMed/Medline database was carried out and the data were summarized by applying a narrative approach using the available evidence based on the literature. The main findings were the following: first, coffee may contribute to the prevention of inflammatory and oxidative stress-related diseases, such as obesity, metabolic syndrome and type 2 diabetes; second, coffee consumption seems to be associated with a lower incidence of several types of cancer and with a reduction in the risk of all-cause mortality; finally, the consumption of up to 400 mg/day (1-4 cups per day) of caffeine is safe. However, the time gap between coffee consumption and some drugs should be taken into account in order to avoid interaction. However, most of the data were based on cross-sectional or/and observational studies highlighting an association of coffee intake and health outcomes; thus, randomized controlled studies are needed in order to identify a causality link.
C1 [Barrea, Luigi] Univ Telemat Pegaso, Dipartimento Sci Umanist, Via Porzio,Isola F2, I-80143 Naples, Italy.
   [Barrea, Luigi; Pugliese, Gabriella; Castellucci, Bianca; Laudisio, Daniela; Savastano, Silvia; Colao, Annamaria; Muscogiuri, Giovanna] Univ Med Sch Naples, Ctr Italiano Cura & Benessere Paziente Obesita CI, Dept Clin Med & Surg, Endocrinol Unit, Via Sergio Pansini 5, I-80131 Naples, Italy.
   [Pugliese, Gabriella; Laudisio, Daniela; Savastano, Silvia; Colao, Annamaria; Muscogiuri, Giovanna] Univ Naples Federico II, Unit Endocrinol, Dipartimento Med Clin & Chirurg, Med Sch Naples, Via Sergio Pansini 5, I-80131 Naples, Italy.
   [Frias-Toral, Evelyn] Univ Catolica Santiago Guayaquil, Sch Med, Guayaquil, Ecuador.
   [El Ghoche, Marwan] Beirut Arab Univ, Fac Hlth Sci, Dept Nutr & Dietet, POB 11-5020 Riad El Solh, Beirut 11072809, Lebanon.
   [Pablo Chapela, Sebastian] Univ Buenos Aires, Fac Med, Dept Bioquim Humana, Buenos Aires, DF, Argentina.
   [Pablo Chapela, Sebastian] Hosp Britan Buenos Aires, Dept Terapia Intens, Buenos Aires, DF, Argentina.
   [de los Angeles Carignano, Maria] Sanatorio Franchin, Intens Care Unit, Bartolome Mitre 3565, Buenos Aires, DF, Argentina.
   [Colao, Annamaria; Muscogiuri, Giovanna] Univ Federico II, Cattedra Unesco Educ Salute & Allo Sviluppo Soste, Naples, Italy.
C3 Pegaso Online University; University of Naples Federico II; Beirut Arab
   University; University of Buenos Aires; Hospital Britanico de Buenos
   Aires; University of Naples Federico II
RP Barrea, L (corresponding author), Univ Telemat Pegaso, Dipartimento Sci Umanist, Via Porzio,Isola F2, I-80143 Naples, Italy.; Barrea, L (corresponding author), Univ Med Sch Naples, Ctr Italiano Cura & Benessere Paziente Obesita CI, Dept Clin Med & Surg, Endocrinol Unit, Via Sergio Pansini 5, I-80131 Naples, Italy.
EM luigi.barrea@unipegaso.it
RI Colao, Annamaria/A-7671-2011; Barrea, Luigi/K-6551-2016; Frias-Toral,
   Evelyn/AAZ-7346-2020; Savastano, Silvia/K-6546-2016
OI Barrea, Luigi/0000-0001-9054-456X; Castellucci,
   Bianca/0000-0001-7297-7492; Frias-Toral, Evelyn/0000-0002-2228-0141; ,
   Gabriella/0000-0002-8127-1755; Chapela, Sebastian
   Pablo/0000-0002-8083-1714; El Ghoch, Marwan/0000-0003-4277-4752;
   Savastano, Silvia/0000-0002-3211-4307
CR Abreu RV, 2011, PHARMACOL BIOCHEM BE, V99, P659, DOI 10.1016/j.pbb.2011.06.010
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alharbi WDM, 2018, METAB BRAIN DIS, V33, P1203, DOI 10.1007/s11011-018-0230-6
   Alonso-Salces RM, 2009, J AGR FOOD CHEM, V57, P4224, DOI 10.1021/jf8037117
   Angeloni G, 2019, FOOD RES INT, V116, P1327, DOI 10.1016/j.foodres.2018.10.022
   Asbaghi O, 2020, NUTR J, V19, DOI 10.1186/s12937-020-00587-z
   Asbaghi O, 2020, COMPLEMENT THER MED, V51, DOI 10.1016/j.ctim.2020.102424
   ASTRUP A, 1990, AM J CLIN NUTR, V51, P759, DOI 10.1093/ajcn/51.5.759
   Bae JH, 2014, INTEGR MED RES, V3, P189
   Bae Jong Myon, 2020, Dement Neurocogn Disord, V19, P108, DOI 10.12779/dnd.2020.19.3.108
   BAK AAA, 1989, NEW ENGL J MED, V321, P1432, DOI 10.1056/NEJM198911233212103
   Quintana JLB, 2007, NEUROL RES, V29, P91, DOI 10.1179/174313206X152546
   Barrea L, 2021, CRIT REV FOOD SCI, V61, P25, DOI 10.1080/10408398.2020.1714542
   Barrea L, 2021, PANMINERVA MED, V63, P349, DOI 10.23736/S0031-0808.21.04213-0
   Barrea L, 2020, J TRANSL MED, V18, DOI 10.1186/s12967-020-02465-y
   Beghi E, 2011, AM J EPIDEMIOL, V174, P1002, DOI 10.1093/aje/kwr229
   Belayneh A, 2020, BIOMED RES INT, V2020, DOI 10.1155/2020/7909703
   Binello A, 2021, FOOD CHEM, V344, DOI 10.1016/j.foodchem.2020.128631
   Bitter NQ, 2020, FOOD CHEM, V320, DOI 10.1016/j.foodchem.2020.126602
   Boekema PJ, 1999, SCAND J GASTROENTERO, V34, P35, DOI 10.1080/003655299750025525
   Borota D, 2014, NAT NEUROSCI, V17, P201, DOI 10.1038/nn.3623
   Bouchard DR, 2010, OBESITY FACTS, V3, P345, DOI 10.1159/000322915
   Bravi F, 2017, EUR J CANCER PREV, V26, P368, DOI [10.1097/cej.0000000000000252, 10.1097/CEJ.0000000000000252]
   Broderick Pamela J, 2005, J Okla State Med Assoc, V98, P380
   Buratti S, 2015, J SCI FOOD AGR, V95, P2192, DOI 10.1002/jsfa.6933
   Cappelletti S, 2018, NUTRIENTS, V10, DOI 10.3390/nu10050611
   Cappelletti S, 2015, CURR NEUROPHARMACOL, V13, P71, DOI 10.2174/1570159X13666141210215655
   Caprioli G, 2015, INT J FOOD SCI NUTR, V66, P505, DOI 10.3109/09637486.2015.1064871
   Carlström M, 2018, NUTR REV, V76, P395, DOI 10.1093/nutrit/nuy014
   Carrillo JA, 2000, CLIN PHARMACOKINET, V39, P127, DOI 10.2165/00003088-200039020-00004
   Chai T, 2020, MINERVA ENDOCRINOL, V45, P12, DOI 10.23736/S0391-1977.18.02832-8
   Cho AS, 2010, FOOD CHEM TOXICOL, V48, P937, DOI 10.1016/j.fct.2010.01.003
   Choi BK, 2016, ASIAN PAC J TROP MED, V9, P616, DOI 10.1016/j.apjtm.2016.05.017
   Ciaramelli C, 2019, FOOD CHEM, V278, P47, DOI 10.1016/j.foodchem.2018.11.063
   Coffeeandhealth, COFF HLTH I SCIENT I
   Crippa A, 2014, AM J EPIDEMIOL, V180, P763, DOI 10.1093/aje/kwu194
   D'Elia L, 2019, EUR J NUTR, V58, P271, DOI 10.1007/s00394-017-1591-z
   Dankowska A, 2017, TALANTA, V172, P215, DOI 10.1016/j.talanta.2017.05.036
   Davidson MH, 2006, AM J CARDIOL, V98, p27I, DOI 10.1016/j.amjcard.2005.12.024
   Davis AP, 2006, BOT J LINN SOC, V152, P465, DOI 10.1111/j.1095-8339.2006.00584.x
   de Mejia EG, 2014, TRENDS ENDOCRIN MET, V25, P489, DOI 10.1016/j.tem.2014.07.003
   Pereira GVD, 2020, ADV FOOD NUTR RES, V91, P65, DOI 10.1016/bs.afnr.2019.10.002
   Pereira GVD, 2019, FOOD CHEM, V272, P441, DOI 10.1016/j.foodchem.2018.08.061
   Déchamp E, 2015, METHODS MOL BIOL, V1224, P275, DOI 10.1007/978-1-4939-1658-0_22
   Derkinderen P, 2014, MOVEMENT DISORD, V29, P976, DOI 10.1002/mds.25882
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Ding M, 2015, CIRCULATION, V132, P2305, DOI 10.1161/CIRCULATIONAHA.115.017341
   Ding M, 2014, CIRCULATION, V129, P643, DOI 10.1161/CIRCULATIONAHA.113.005925
   Dunwiddie TV, 2001, ANNU REV NEUROSCI, V24, P31, DOI 10.1146/annurev.neuro.24.1.31
   Mesas AE, 2011, AM J CLIN NUTR, V94, P1113, DOI 10.3945/ajcn.111.016667
   Farias-Pereira R, 2019, FOOD SCI BIOTECHNOL, V28, P1287, DOI 10.1007/s10068-019-00662-0
   Federico S, 2012, EXPERT OPIN THER PAT, V22, P369, DOI 10.1517/13543776.2012.669375
   dos Santos MKF, 2018, N-S ARCH PHARMACOL, V391, P1301, DOI 10.1007/s00210-018-1570-9
   Ferguson KK, 2017, ENVIRON SCI TECHNOL, V51, P4652, DOI 10.1021/acs.est.7b01252
   Fisone G, 2004, CELL MOL LIFE SCI, V61, P857, DOI 10.1007/s00018-003-3269-3
   Flambeau KJ, 2017, FOOD SCI BIOTECHNOL, V26, P1245, DOI 10.1007/s10068-017-0168-1
   Freedman ND, 2012, NEW ENGL J MED, V366, P1891, DOI 10.1056/NEJMoa1112010
   Gao S, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/7649080
   Gapstur SM, 2017, CANCER EPIDEM BIOMAR, V26, P1477, DOI [10.1158/1055-9965.EPI-17-0353, 10.1158/1055-9965.epi-17-0353]
   Gebremedhin D, 2010, J CEREBR BLOOD F MET, V30, P1777, DOI 10.1038/jcbfm.2010.70
   Ghavami HS, 2021, BMC CARDIOVASC DISOR, V21, DOI 10.1186/s12872-021-02058-7
   Giesbrecht T, 2010, NUTR NEUROSCI, V13, P283, DOI 10.1179/147683010X12611460764840
   Gökcen BB, 2019, CRIT REV FOOD SCI, V59, P336, DOI 10.1080/10408398.2017.1369391
   González S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051287
   Gorji Z, 2019, PHYTOMEDICINE, V63, DOI 10.1016/j.phymed.2019.153018
   Grgic J, 2020, BRIT J SPORT MED, V54, P681, DOI 10.1136/bjsports-2018-100278
   Grosso G, 2017, NUTRIENTS, V9, DOI 10.3390/nu9080890
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Gunter MJ, 2017, ANN INTERN MED, V167, P236, DOI 10.7326/M16-2945
   Gurwara S, 2019, NUTRIENTS, V11, DOI 10.3390/nu11030613
   Han TJ, 2016, IRAN J PUBLIC HEALTH, V45, P1126
   HAN X, 1988, LYMPHOKINE RES, V7, P227
   Hang D, 2019, AM J CLIN NUTR, V109, P635, DOI 10.1093/ajcn/nqy295
   Hearn JK, 2020, J AM ACAD PSYCHIATRY, V48, P376, DOI 10.29158/JAAPL.003923-20
   Heckman MA, 2010, J FOOD SCI, V75, pR77, DOI 10.1111/j.1750-3841.2010.01561.x
   Henkler Frank, 2012, Exp Suppl, V101, P107, DOI 10.1007/978-3-7643-8340-4_5
   Henry-Vitrac C, 2010, J AGR FOOD CHEM, V58, P4141, DOI 10.1021/jf9044827
   Higdon JV, 2006, CRIT REV FOOD SCI, V46, P101, DOI 10.1080/10408390500400009
   Hildebrand F, 2013, GENOME BIOL, V14, DOI 10.1186/gb-2013-14-1-r4
   Hino A, 2007, DIABETES RES CLIN PR, V76, P383, DOI 10.1016/j.diabres.2006.09.033
   Hiramatsu T, 2013, CLIN CHEM LAB MED, V51, P1233, DOI 10.1515/cclm-2012-0700
   Hosseinabadi S, 2020, COMPLEMENT THER MED, V49, DOI 10.1016/j.ctim.2019.102290
   Hu G, 2007, MOVEMENT DISORD, V22, P2242, DOI 10.1002/mds.21706
   Huang K, 2015, J SCI FOOD AGR, V95, P1903, DOI 10.1002/jsfa.6896
   Huxley R, 2009, ARCH INTERN MED, V169, P2053, DOI 10.1001/archinternmed.2009.439
   Ikram M, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9090902
   Iriondo-DeHond A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010088
   Iriondo-DeHond A, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10091219
   Iwai K, 2012, FOOD SCI TECHNOL RES, V18, P849, DOI 10.3136/fstr.18.849
   James JE, 2004, PSYCHOSOM MED, V66, P63, DOI 10.1097/10.PSY.0000107884.78247.F9
   Jee SH, 2001, AM J EPIDEMIOL, V153, P353, DOI 10.1093/aje/153.4.353
   Jiang WJ, 2013, GYNECOL ONCOL, V129, P620, DOI 10.1016/j.ygyno.2013.03.014
   Jiménez-Zamora A, 2015, LWT-FOOD SCI TECHNOL, V61, P12, DOI 10.1016/j.lwt.2014.11.031
   Jin T, 2020, NUTRIENTS, V12, DOI 10.3390/nu12082228
   Johnston KL, 2003, AM J CLIN NUTR, V78, P728, DOI 10.1093/ajcn/78.4.728
   Jomova K, 2011, TOXICOLOGY, V283, P65, DOI 10.1016/j.tox.2011.03.001
   Juliano LM, 2004, PSYCHOPHARMACOLOGY, V176, P1, DOI 10.1007/s00213-004-2000-x
   Kahathuduwa CN, 2017, NUTR NEUROSCI, V20, P369, DOI [10.1080/1028415x.2016.1144845, 10.1080/1028415X.2016.1144845]
   Kalra S., 2020, MINERVA ENDOCRINOL, DOI [10.23736/S0391-1977.20.03353-2, DOI 10.23736/S0391-1977.20.03353-2]
   Kempf K, 2010, AM J CLIN NUTR, V91, P950, DOI 10.3945/ajcn.2009.28548
   Kerimi A, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-76558-5
   Kim HJ, 2016, BMB REP, V49, P111, DOI 10.5483/BMBRep.2016.49.2.128
   Kim JY, 2006, BIOFACTORS, V26, P17, DOI 10.1002/biof.5520260103
   Kim JY, 2004, FEBS LETT, V569, P321, DOI 10.1016/j.febslet.2004.05.070
   Kim SA, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122992
   Kim Y, 2019, EUR J EPIDEMIOL, V34, P731, DOI 10.1007/s10654-019-00524-3
   Klingel T, 2020, FOODS, V9, DOI 10.3390/foods9050665
   Kumar VHS, 2019, CHILDREN-BASEL, V6, DOI 10.3390/children6110118
   Lara DR, 2010, J ALZHEIMERS DIS, V20, pS239, DOI 10.3233/JAD-2010-1378
   Laudisio D, 2018, EUR J OBSTET GYN R B, V230, P217, DOI 10.1016/j.ejogrb.2018.03.050
   Lee A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061274
   Lee KJ, 2007, TOXICOL LETT, V173, P80, DOI 10.1016/j.toxlet.2007.06.008
   Leviton A, 2002, FOOD CHEM TOXICOL, V40, P1271, DOI 10.1016/S0278-6915(02)00092-3
   Liu CW, 2018, AM J PHYSIOL-ENDOC M, V314, pE433, DOI 10.1152/ajpendo.00094.2017
   Liu JB, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0147056
   Liu YJ, 2019, CNS NEUROSCI THER, V25, P899, DOI 10.1111/cns.13190
   Loftfield E, 2015, AM J EPIDEMIOL, V182, P1010, DOI 10.1093/aje/kwv146
   Ludwig IA, 2014, FOOD FUNCT, V5, P1695, DOI [10.1039/c4fo00042k, 10.1039/C4FO00042K]
   Lv XW, 2010, INFLAMM RES, V59, P635, DOI 10.1007/s00011-010-0176-6
   Martini D, 2016, MOLECULES, V21, DOI 10.3390/molecules21080979
   Marventano S, 2016, CLIN NUTR, V35, P1269, DOI 10.1016/j.clnu.2016.03.012
   Marx B, 2016, M S-MED SCI, V32, P485, DOI 10.1051/medsci/20163205015
   Matsui T, 2001, J AGR FOOD CHEM, V49, P1948, DOI 10.1021/jf001251u
   McEvoy CT, 2014, J ACAD NUTR DIET, V114, P1759, DOI 10.1016/j.jand.2014.05.001
   McGaugh JL, 2000, SCIENCE, V287, P248, DOI 10.1126/science.287.5451.248
   Mena P, 2017, TRIALS, V18, DOI 10.1186/s13063-017-2271-2
   Metro D, 2017, J CLIN TRANSL ENDOCR, V10, P22, DOI 10.1016/j.jcte.2017.10.001
   Micek A, 2018, INT J FOOD SCI NUTR, V69, P417, DOI 10.1080/09637486.2017.1373752
   Mills CE, 2015, BRIT J NUTR, V113, P1220, DOI 10.1017/S0007114514003948
   Miranda AM, 2021, CLIN NUTR, V40, P542, DOI 10.1016/j.clnu.2020.05.052
   Mormile R, 2019, MINERVA ENDOCRINOL, V44, P331, DOI 10.23736/S0391-1977.18.02816-X
   Morvaridi M, 2020, J DIABETES METAB DIS, V19, P645, DOI 10.1007/s40200-020-00536-x
   Mostofsky E, 2012, CIRC-HEART FAIL, V5, P401, DOI 10.1161/CIRCHEARTFAILURE.112.967299
   Moura-Nunes N, 2009, INT J FOOD SCI NUTR, V60, P173, DOI 10.1080/09637480903158893
   Murase T, 2011, AM J PHYSIOL-ENDOC M, V300, pE122, DOI 10.1152/ajpendo.00441.2010
   Muscogiuri G, 2022, CRIT REV FOOD SCI, V62, P6947, DOI 10.1080/10408398.2021.1908223
   Muscogiuri G, 2019, CRIT REV FOOD SCI, V59, P2158, DOI 10.1080/10408398.2018.1506979
   Narita Y, 2009, J AGR FOOD CHEM, V57, P9218, DOI 10.1021/jf9017383
   Nehlig A, 2018, PHARMACOL REV, V70, P384, DOI 10.1124/pr.117.014407
   Nehlig Astrid, 2010, Dialogues Clin Neurosci, V12, P255
   Nie KC, 2016, MINERVA MED, V107, P270
   Nieber K, 2017, PLANTA MED, V83, P1256, DOI 10.1055/s-0043-115007
   Nordestgaard AT, 2015, INT J EPIDEMIOL, V44, P551, DOI 10.1093/ije/dyv083
   Oh JK, 2015, INT J CANCER, V137, P1979, DOI 10.1002/ijc.29569
   Ong KW, 2013, BIOCHEM PHARMACOL, V85, P1341, DOI 10.1016/j.bcp.2013.02.008
   Ongo EA, 2020, FOOD RES INT, V134, DOI 10.1016/j.foodres.2020.109227
   Paiva CLRS, 2019, CRIT REV FOOD SCI, V59, P652, DOI 10.1080/10408398.2017.1386159
   Pan MH, 2016, FOOD FUNCT, V7, P4481, DOI 10.1039/c6fo01168c
   Papakonstantinou E, 2016, NUTR J, V15, DOI 10.1186/s12937-016-0146-0
   Park SY, 2018, CANCER EPIDEM BIOMAR, V27, P928, DOI 10.1158/1055-9965.EPI-18-0093
   Park SY, 2017, ANN INTERN MED, V167, P228, DOI 10.7326/M16-2472
   Paschou SA, 2019, MINERVA ENDOCRINOL, V44, P333, DOI 10.23736/S0391-1977.19.03040-2
   Peerapen P, 2018, ADV NUTR, V9, P419, DOI 10.1093/advances/nmy016
   Pellegrini N, 2003, J NUTR, V133, P2812, DOI 10.1093/jn/133.9.2812
   Poole R, 2017, BMJ-BRIT MED J, V359, DOI 10.1136/bmj.j5024
   Ren XP, 2020, FRONT NEUROSCI-SWITZ, V14, DOI 10.3389/fnins.2020.602697
   Ricketts ML, 2007, MOL ENDOCRINOL, V21, P1603, DOI 10.1210/me.2007-0133
   Riise T, 2003, NEUROLOGY, V61, P1122, DOI 10.1212/01.WNL.0000081305.66687.D2
   Ríos-Hoyo A, 2016, CURR OBES REP, V5, P262, DOI 10.1007/s13679-016-0214-y
   Rogers PJ, 2010, NEUROPSYCHOPHARMACOL, V35, P1973, DOI 10.1038/npp.2010.71
   Ruggeri RM, 2021, THYROID, V31, P96, DOI 10.1089/thy.2020.0299
   Saeed M, 2019, CRIT REV FOOD SCI, V59, P3293, DOI 10.1080/10408398.2018.1489368
   Salari-Moghaddam A, 2019, J CLIN ENDOCR METAB, V104, P5346, DOI 10.1210/jc.2019-00637
   Salazar-Martinez E, 2004, ANN INTERN MED, V140, P1, DOI 10.7326/0003-4819-140-1-200401060-00005
   Santos RMM, 2016, EUR J NUTR, V55, P1345, DOI 10.1007/s00394-016-1206-0
   Sartorelli DS, 2010, AM J CLIN NUTR, V91, P1002, DOI 10.3945/ajcn.2009.28741
   Savanelli MC, 2016, ENDOCRINE, V52, P111, DOI 10.1007/s12020-015-0779-3
   Schmit SL, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-72993-6
   Schouten MA, 2020, CRIT REV FOOD SCI, V60, P3807, DOI 10.1080/10408398.2019.1708264
   Schwarzschild Michael A., 2003, Neurology, V61, pS55
   Serra F, 2005, RAPID COMMUN MASS SP, V19, P2111, DOI 10.1002/rcm.2034
   Setiawan VW, 2015, GASTROENTEROLOGY, V148, P118, DOI 10.1053/j.gastro.2014.10.005
   Shang F, 2016, DIABETES METAB, V42, P80, DOI 10.1016/j.diabet.2015.09.001
   Shimamoto T, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0065996
   Shimoda H., 2006, BMC COMPLEM ALTERN M, V6, DOI [10.1186/1472-6882-6-9, DOI 10.1186/1472-6882-6-9]
   Sinha RA, 2014, HEPATOLOGY, V59, P1366, DOI 10.1002/hep.26667
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   SONG SJ, 2014, EVID-BASED COMPL ALT, V2014, DOI DOI 10.1155/2014/718379
   Stefan N, 2020, LANCET DIABETES ENDO, V8, P616, DOI 10.1016/S2213-8587(20)30110-8
   Steffen M, 2012, J HYPERTENS, V30, P2245, DOI 10.1097/HJH.0b013e3283588d73
   Sudeep HV, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1258-y
   Tajik N, 2017, EUR J NUTR, V56, P2215, DOI 10.1007/s00394-017-1379-1
   Takami H, 2013, J EPIDEMIOL, V23, P12, DOI 10.2188/jea.JE20120053
   Temple JL, 2017, FRONT PSYCHIATRY, V8, DOI 10.3389/fpsyt.2017.00080
   Thorn CF, 2012, PHARMACOGENET GENOM, V22, P389, DOI 10.1097/FPC.0b013e3283505d5e
   Tian T, 2017, J AGR FOOD CHEM, V65, P2784, DOI 10.1021/acs.jafc.6b04716
   Turnbull D, 2017, REGUL TOXICOL PHARM, V89, P165, DOI 10.1016/j.yrtph.2017.07.025
   Um CY, 2020, CANCER EPIDEMIOL, V67, DOI 10.1016/j.canep.2020.101730
   Valdez RC, 2011, J PEDIATR-US, V158, P38, DOI 10.1016/j.jpeds.2010.06.051
   van Dam RM, 2020, NEW ENGL J MED, V383, P369, DOI 10.1056/NEJMra1816604
   Vignoli JA, 2014, FOOD RES INT, V61, P279, DOI 10.1016/j.foodres.2013.06.006
   Voskoboinik A, 2019, TRENDS CARDIOVAS MED, V29, P345, DOI 10.1016/j.tcm.2018.09.019
   Wang LF, 2016, AUST NZ J PSYCHIAT, V50, P228, DOI 10.1177/0004867415603131
   Watanabe S, 2017, METAB SYNDR RELAT D, V15, P170, DOI 10.1089/met.2016.0114
   Williamson G, 2020, FOOD FUNCT, V11, P4826, DOI [10.1039/D0FO01168A, 10.1039/d0fo01168a]
   Willson C, 2018, TOXICOL REP, V5, P1140, DOI 10.1016/j.toxrep.2018.11.002
   Winiarska-Mieczan A, 2021, BIOL TRACE ELEM RES, V199, P2420, DOI 10.1007/s12011-020-02332-3
   Wondmkun YT, 2020, DIABET METAB SYND OB, V13, P3611, DOI 10.2147/DMSO.S275898
   Worku M, 2019, FOOD CHEM, V290, P295, DOI 10.1016/j.foodchem.2019.03.135
   Xie Y, 2016, EUR J CLIN NUTR, V70, P199, DOI 10.1038/ejcn.2015.96
   Yan R, 2018, P NATL ACAD SCI USA, V115, pE12053, DOI 10.1073/pnas.1813365115
   Yang LL, 2017, ENVIRON POLLUT, V223, P305, DOI 10.1016/j.envpol.2017.01.027
   Yenisetti SC, 2016, AIMS PUBLIC HEALTH, V3, P407, DOI 10.3934/publichealth.2016.2.407
   Zhang Y, 2011, NUTR METAB CARDIOVAS, V21, P418, DOI 10.1016/j.numecd.2009.10.020
   Zhao YY, 2012, HYPERTENS RES, V35, P370, DOI 10.1038/hr.2011.195
   Zheng GD, 2014, BRIT J NUTR, V112, P1034, DOI 10.1017/S0007114514001652
   Zhou Q, 2015, SCI REP-UK, V5, DOI 10.1038/srep13410
   Zuñiga LY, 2018, J MED FOOD, V21, P469, DOI 10.1089/jmf.2017.0110
NR 208
TC 64
Z9 64
U1 3
U2 66
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD APR 3
PY 2023
VL 63
IS 9
BP 1238
EP 1261
DI 10.1080/10408398.2021.1963207
EA AUG 2021
PG 24
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA D4AH4
UT WOS:000690826100001
PM 34455881
DA 2025-06-11
ER

PT J
AU Laudermilk, LT
   Harper, KM
   Moy, SS
   Runyon, S
   Zhou, B
   Koller, B
   Maitra, R
AF Laudermilk, Lucas T.
   Harper, Kathryn M.
   Moy, Sheryl S.
   Runyon, Scott
   Zhou, Bin
   Koller, Beverly
   Maitra, Rangan
TI Aplnr knockout mice display sex-specific changes in conditioned fear
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Apelin; receptor; behavior; conditioned fear; PTSD
ID ORPHAN RECEPTOR APJ; APELIN RECEPTOR; ENDOGENOUS LIGAND; PEPTIDE APELIN;
   SUPPRESSES APOPTOSIS; CONTEXTUAL FEAR; BLOOD-PRESSURE; EXPRESSION;
   EXTINCTION; KINASE
AB The G-protein-coupled receptor APLNR and its ligands apelin and ELABELA/TODDLER/apela comprise the apelinergic system, a signaling pathway that is critical during development and physiological homeostasis. Targeted regulation of the receptor has been proposed to treat several important diseases including heart failure, pulmonary arterial hypertension and metabolic syndrome. The apelinergic system is widely expressed within the central nervous system (CNS). However, the role of this system in the CNS has not been completely elucidated.
   Utilizing an Aplnr knockout mouse model, we report here results from tests of sensory ability, locomotion, reward preference, social preference, learning and memory, and anxiety. We find that knockout of Aplnr leads to significant effects on acoustic startle response and sex-specific effects on conditioned fear responses without significant changes in baseline anxiety. In particular, male Aplnr knockout mice display enhanced context- and cue-dependent fear responses. Our results complement previous reports that exogenous Apelin administration reduced conditioned fear and freezing responses in rodent models, and future studies will explore the therapeutic benefit of APLNR-targeted drugs in rodent models of PTSD.
C1 [Laudermilk, Lucas T.; Runyon, Scott; Maitra, Rangan] RTI Int, Ctr Drug Discovery, Res Triangle Pk, NC USA.
   [Harper, Kathryn M.; Moy, Sheryl S.] Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA.
   [Harper, Kathryn M.; Moy, Sheryl S.] Univ N Carolina, Carolina Inst Dev Disabil, Chapel Hill, NC 27599 USA.
   [Zhou, Bin] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, 320 Yueyang Rd,Life Sci Res Bldg A-2112, Shanghai 200031, Peoples R China.
   [Koller, Beverly] Univ N Carolina, Sch Med, Dept Genet, Chapel Hill, NC 27599 USA.
C3 Research Triangle Institute; University of North Carolina; University of
   North Carolina Chapel Hill; University of North Carolina; University of
   North Carolina Chapel Hill; Chinese Academy of Sciences; Center for
   Excellence in Molecular Cell Science, CAS; University of North Carolina
   School of Medicine; University of North Carolina; University of North
   Carolina Chapel Hill
RP Maitra, R (corresponding author), POB 12194, Res Triangle Pk, NC 27709 USA.
EM rmaitra@rti.org
RI Ezzell, Jennifer/ABF-6317-2021
OI Ezzell, Jennifer/0000-0002-5142-4685; Laudermilk,
   Lucas/0000-0001-6181-0136; Harper, Kathryn/0000-0002-6297-0032
FU RTI International; NIH [U01HG004085]; CSD Consortium [U01HG004080];
   CHORI [U42RR024244]; Eunice Kennedy Shriver National Institute of Child
   Health and Human Development (NICHD) [U54 HD079124];  [R01DK103625];
   National Institute of Diabetes and Digestive and Kidney Diseases
   [R01DK103625] Funding Source: NIH RePORTER
FX This work has been supported by R01DK103625 to R.M. and internal funding
   from RTI International.The knockout mouse strain used for this research
   project was generated by the trans-NIH Knock-Out Mouse Project (KOMP)
   and obtained from the KOMP Repository (www.komp.org).NIH grants to
   Velocigene at Regeneron Inc (U01HG004085) and the CSD Consortium
   (U01HG004080) funded the generation of gene-targeted ES cells for 8500
   genes in the KOMP Program and archived and distributed by the KOMP
   Repository at UC Davis and CHORI (U42RR024244).The UNC CIDD Mouse
   Behavioral Phenotyping Laboratory is funded by the Eunice Kennedy
   Shriver National Institute of Child Health and Human Development (NICHD;
   U54 HD079124).Histological services provided by the Histology Research
   Core Facility in the Department of Cell Biology and Physiology at the
   University of North Carolina, Chapel Hill NC.
CR Alexander GM, 2019, NEUROBIOL LEARN MEM, V163, DOI 10.1016/j.nlm.2019.107044
   Ashley EA, 2005, CARDIOVASC RES, V65, P73, DOI 10.1016/j.cardiores.2004.08.018
   Attané C, 2012, DIABETES, V61, P310, DOI 10.2337/db11-0100
   Bai B, 2008, ACTA BIOCH BIOPH SIN, V40, P311, DOI 10.1111/j.1745-7270.2008.00403.x
   Bernier BE, 2017, J NEUROSCI, V37, P6359, DOI 10.1523/JNEUROSCI.3029-16.2017
   Boyer NP, 2018, ENEURO, V5, DOI 10.1523/ENEURO.0186-18.2018
   Castan-Laurell I, 2008, EUR J ENDOCRINOL, V158, P905, DOI 10.1530/EJE-08-0039
   Charo DN, 2009, AM J PHYSIOL-HEART C, V297, pH1904, DOI 10.1152/ajpheart.00686.2009
   Dai TT, 2018, NEUROSCIENCE, V390, P151, DOI 10.1016/j.neuroscience.2018.08.018
   Deslauriers J, 2018, BIOL PSYCHIAT, V83, P895, DOI 10.1016/j.biopsych.2017.11.019
   Devic E, 1999, MECH DEVELOP, V84, P199, DOI 10.1016/S0925-4773(99)00081-7
   Dray C, 2008, CELL METAB, V8, P437, DOI 10.1016/j.cmet.2008.10.003
   Duan JL, 2019, J NEUROINFLAMM, V16, DOI 10.1186/s12974-019-1406-7
   Flahault A, 2017, FRONT ENDOCRINOL, V8, DOI 10.3389/fendo.2017.00120
   Gresack JE, 2009, NEUROSCIENCE, V159, P451, DOI 10.1016/j.neuroscience.2009.01.009
   Habata Y, 1999, BBA-MOL CELL RES, V1452, P25, DOI 10.1016/S0167-4889(99)00114-7
   Han L, 2016, NEUROCHEM RES, V41, P2345, DOI 10.1007/s11064-016-1948-3
   Higuchi K, 2007, ENDOCRINOLOGY, V148, P2690, DOI 10.1210/en.2006-1270
   Hoskins M, 2015, BRIT J PSYCHIAT, V206, P93, DOI 10.1192/bjp.bp.114.148551
   Hwangbo C, 2017, SCI TRANSL MED, V9, DOI 10.1126/scitranslmed.aad4000
   Kagiyama S, 2005, REGUL PEPTIDES, V125, P55, DOI 10.1016/j.regpep.2004.07.033
   Kang YJ, 2013, CIRC RES, V113, P22, DOI 10.1161/CIRCRESAHA.113.301324
   Keiser AA, 2017, NEUROPSYCHOPHARMACOL, V42, P397, DOI 10.1038/npp.2016.174
   Kuba K, 2007, CIRC RES, V101, pE32, DOI 10.1161/CIRCRESAHA.107.158659
   Lein ES, 2007, NATURE, V445, P168, DOI 10.1038/nature05453
   Liu QZ, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms7020
   Madisen L, 2010, NAT NEUROSCI, V13, P133, DOI 10.1038/nn.2467
   Maguire JJ, 2009, HYPERTENSION, V54, P598, DOI 10.1161/HYPERTENSIONAHA.109.134619
   Masri B, 2004, FASEB J, V18, P1909, DOI 10.1096/fj.04-1930fje
   Masri B, 2002, BIOCHEM BIOPH RES CO, V290, P539, DOI 10.1006/bbrc.2001.6230
   Masri B, 2006, J BIOL CHEM, V281, P18317, DOI 10.1074/jbc.M600606200
   Matsuda S, 2015, NEUROBIOL LEARN MEM, V123, P117, DOI 10.1016/j.nlm.2015.05.009
   Medhurst AD, 2003, J NEUROCHEM, V84, P1162, DOI 10.1046/j.1471-4159.2003.01587.x
   Narayanan S, 2020, BIOORGAN MED CHEM, V28, DOI 10.1016/j.bmc.2019.115237
   Narayanan S, 2015, J MED CHEM, V58, P7913, DOI 10.1021/acs.jmedchem.5b00527
   Newson MJF, 2013, J ENDOCRINOL, V216, P99, DOI 10.1530/JOE-12-0375
   O'Carroll AM, 2000, BBA-GENE STRUCT EXPR, V1492, P72, DOI 10.1016/S0167-4781(00)00072-5
   O'Carroll AM, 2003, J NEUROENDOCRINOL, V15, P1095, DOI 10.1046/j.1365-2826.2003.01102.x
   O'Carroll AM, 2013, J ENDOCRINOL, V219, pR13, DOI 10.1530/JOE-13-0227
   O'Donnell LA, 2007, J NEUROCHEM, V102, P1905, DOI 10.1111/j.1471-4159.2007.04645.x
   ODOWD BF, 1993, GENE, V136, P355, DOI 10.1016/0378-1119(93)90495-O
   Olney JJ, 2018, PHARMACOL BIOCHEM BE, V168, P1, DOI 10.1016/j.pbb.2018.03.006
   Pang H, 2014, INT J MOL MED, V34, P756, DOI 10.3892/ijmm.2014.1829
   Pope GR, 2012, PEPTIDES, V33, P139, DOI 10.1016/j.peptides.2011.12.005
   Regard JB, 2008, CELL, V135, P561, DOI 10.1016/j.cell.2008.08.040
   Roberts EM, 2009, J ENDOCRINOL, V202, P453, DOI 10.1677/JOE-09-0134
   Sandal S, 2015, NEUROSCI LETT, V602, P133, DOI 10.1016/j.neulet.2015.06.059
   Slouzkey I, 2016, LEARN MEMORY, V23, P723, DOI 10.1101/lm.041806.116
   Spanos M, 2012, BEHAV BRAIN RES, V230, P158, DOI 10.1016/j.bbr.2012.02.010
   Stout DM, 2019, BIOL PSYCHIAT, V86, P874, DOI 10.1016/j.biopsych.2019.09.026
   Sui L, 2008, LEARN MEMORY, V15, P762, DOI 10.1101/lm.1067808
   Szokodi I, 2002, CIRC RES, V91, P434, DOI 10.1161/01.RES.0000033522.37861.69
   Taheri S, 2002, BIOCHEM BIOPH RES CO, V291, P1208, DOI 10.1006/bbrc.2002.6575
   Tang SY, 2007, PEPTIDES, V28, P708, DOI 10.1016/j.peptides.2006.10.005
   Tatemoto K, 2001, REGUL PEPTIDES, V99, P87, DOI 10.1016/S0167-0115(01)00236-1
   Tekin S, 2017, ARCH PHYSIOL BIOCHEM, V123, P9, DOI 10.1080/13813455.2016.1211709
   Tronson NC, 2019, TRENDS NEUROSCI, V42, P680, DOI 10.1016/j.tins.2019.07.009
   VanElzakker MB, 2014, NEUROBIOL LEARN MEM, V113, P3, DOI 10.1016/j.nlm.2013.11.014
   Wang ZF, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-15729-4
   Xie H, 2006, REGUL PEPTIDES, V134, P118, DOI 10.1016/j.regpep.2006.02.004
   Xie H, 2007, APOPTOSIS, V12, P247, DOI 10.1007/s10495-006-0489-7
   Yeganeh-Hajahmadi M, 2017, HYPERTENS RES, V40, P732, DOI 10.1038/hr.2017.28
   Yu Z, 2019, BIOL PSYCHIAT, V86, P899, DOI 10.1016/j.biopsych.2019.05.027
   Yue P, 2010, AM J PHYSIOL-ENDOC M, V298, pE59, DOI 10.1152/ajpendo.00385.2009
   Zeng XJ, 2010, EXP CELL RES, V316, P1773, DOI 10.1016/j.yexcr.2010.02.005
   Zhao H, 2018, CELL REP, V25, P1241, DOI 10.1016/j.celrep.2018.10.015
NR 66
TC 1
Z9 1
U1 0
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD FEB 26
PY 2021
VL 400
AR 113059
DI 10.1016/j.bbr.2020.113059
PG 10
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA PT4SQ
UT WOS:000608605300001
PM 33309737
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sorrentino, SA
   Besler, C
   Rohrer, L
   Meyer, M
   Heinrich, K
   Bahlmann, FH
   Mueller, M
   Horváth, T
   Doerries, C
   Heinemann, M
   Flemmer, S
   Markowski, A
   Manes, C
   Bahr, MJ
   Haller, H
   von Eckardstein, A
   Drexler, H
   Landmesser, U
AF Sorrentino, Sajoscha A.
   Besler, Christian
   Rohrer, Lucia
   Meyer, Martin
   Heinrich, Kathrin
   Bahlmann, Ferdinand H.
   Mueller, Maja
   Horvath, Tibor
   Doerries, Carola
   Heinemann, Mariko
   Flemmer, Stella
   Markowski, Andrea
   Manes, Costantina
   Bahr, Matthias J.
   Haller, Hermann
   von Eckardstein, Arnold
   Drexler, Helmut
   Landmesser, Ulf
TI Endothelial-Vasoprotective Effects of High-Density Lipoprotein Are
   Impaired in Patients With Type 2 Diabetes Mellitus but Are Improved
   After Extended-Release Niacin Therapy
SO CIRCULATION
LA English
DT Article
DE diabetes mellitus; endothelium; free radicals; lipids; nitric oxide
ID REVERSE CHOLESTEROL TRANSPORT; PROGENITOR-CELL MOBILIZATION; VASCULAR
   OXIDATIVE STRESS; SCAVENGER RECEPTOR-BI; NITRIC-OXIDE SYNTHASE;
   DOUBLE-BLIND; METABOLIC SYNDROME; HDL CHOLESTEROL; TORCETRAPIB;
   SIMVASTATIN
AB Background-High-density lipoprotein (HDL)-raising therapies are currently under intense evaluation, but the effects of HDL may be highly heterogeneous. We therefore compared the endothelial effects of HDL from healthy subjects and from patients with type 2 diabetes mellitus and low HDL (meeting the criteria for metabolic syndrome), who are frequently considered for HDL-raising therapies. Moreover, in diabetic patients, we examined the impact of extended-release (ER) niacin therapy on the endothelial effects of HDL.
   Methods and Results-HDL was isolated from healthy subjects (n = 10) and patients with type 2 diabetes (n = 33) by sequential ultracentrifugation. Effects of HDL on endothelial nitric oxide and superoxide production were characterized by electron spin resonance spectroscopy analysis. Effects of HDL on endothelium-dependent vasodilation and early endothelial progenitor cell-mediated endothelial repair were examined. Patients with diabetes were randomized to a 3-month therapy with ER niacin (1500 mg/d) or placebo, and endothelial effects of HDL were characterized. HDL from healthy subjects stimulated endothelial nitric oxide production, reduced endothelial oxidant stress, and improved endothelium-dependent vasodilation and early endothelial progenitor cell-mediated endothelial repair. In contrast, these beneficial endothelial effects of HDL were not observed in HDL from diabetic patients, which suggests markedly impaired endothelial-protective properties of HDL. ER niacin therapy improved the capacity of HDL to stimulate endothelial nitric oxide, to reduce superoxide production, and to promote endothelial progenitor cell-mediated endothelial repair. Further measurements suggested increased lipid oxidation of HDL in diabetic patients, and a reduction after ER niacin therapy.
   Conclusions-HDL from patients with type 2 diabetes mellitus and metabolic syndrome has substantially impaired endothelial-protective effects compared with HDL from healthy subjects. ER niacin therapy not only increases HDL plasma levels but markedly improves endothelial-protective functions of HDL in these patients, which is potentially more important.
C1 [Sorrentino, Sajoscha A.; Besler, Christian; Meyer, Martin; Mueller, Maja; Horvath, Tibor; Doerries, Carola; Heinemann, Mariko; Flemmer, Stella; Markowski, Andrea; Manes, Costantina; Drexler, Helmut; Landmesser, Ulf] Hannover Med Sch, Klin Kardiol & Angiol, D-30623 Hannover, Germany.
   [Sorrentino, Sajoscha A.; Bahlmann, Ferdinand H.; Haller, Hermann] Hannover Med Sch, Klin Nieren & Hochdruck Erkrankungen, D-30623 Hannover, Germany.
   [Markowski, Andrea; Bahr, Matthias J.] Hannover Med Sch, Klin Gastroenterol Hepatol & Endokrinol, D-30623 Hannover, Germany.
   [Besler, Christian; Meyer, Martin; Heinrich, Kathrin; Mueller, Maja; Doerries, Carola; Manes, Costantina; Landmesser, Ulf] Univ Zurich Hosp, Ctr Cardiovasc, CH-8091 Zurich, Switzerland.
   [Rohrer, Lucia; von Eckardstein, Arnold] Univ Zurich, Inst Clin Chem, Zurich, Switzerland.
   [Besler, Christian; Rohrer, Lucia; von Eckardstein, Arnold; Landmesser, Ulf] Univ Zurich, Zurich Ctr Integrated Human Physiol, Zurich, Switzerland.
C3 Hannover Medical School; Hannover Medical School; Hannover Medical
   School; University of Zurich; University Zurich Hospital; University of
   Zurich; University of Zurich; Zurich Center Integrative Human Physiology
   (ZIHP)
RP Landmesser, U (corresponding author), Univ Zurich Hosp, Ctr Cardiovasc, Ramistr 100,C Hof 111, CH-8091 Zurich, Switzerland.
EM Ulf.Landmesser@usz.ch
RI Landmesser, Ulf/NJT-0954-2025; Bahr, Matthias/AGR-8512-2022; Meyer,
   Martin/H-4307-2012
OI Bahr, Matthias J./0000-0001-6242-5299
FU Deutsche Forschungsgemeinschaft [LA 1432/4-1]; Merck (Darmstadt,
   Germany); Swiss National Research Foundation [3100A0-116404/1]; European
   Union [LSHM-C-2006-037631]; Zurich Center of Integrated Human Physiology
   (University of Zurich, Zurich, Switzerland)
FX This work was supported by the Deutsche Forschungsgemeinschaft (LA
   1432/4-1) and a research grant from Merck (Darmstadt, Germany).
   Furthermore, the project was supported by the Swiss National Research
   Foundation (grant 3100A0-116404/1), a European Union grant
   (LSHM-C-2006-037631), and the Zurich Center of Integrated Human
   Physiology (University of Zurich, Zurich, Switzerland).
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Ansell BJ, 2003, CIRCULATION, V108, P2751, DOI 10.1161/01.CIR.0000103624.14436.4B
   Asahara T, 1997, SCIENCE, V275, P964, DOI 10.1126/science.275.5302.964
   Ashen MD, 2005, NEW ENGL J MED, V353, P1252, DOI 10.1056/NEJMcp044370
   Bahlmann FH, 2004, BLOOD, V103, P921, DOI 10.1182/blood-2003-04-1284
   Barter P, 2007, NEW ENGL J MED, V357, P1301, DOI 10.1056/NEJMoa064278
   Barter PJ, 2007, NEW ENGL J MED, V357, P2109, DOI 10.1056/NEJMoa0706628
   Bisoendial RJ, 2003, CIRCULATION, V107, P2944, DOI 10.1161/01.CIR.0000070934.69310.1A
   Bots ML, 2007, LANCET, V370, P153, DOI 10.1016/S0140-6736(07)61088-5
   Brouchet L, 2001, CIRCULATION, V103, P423
   Brown BG, 2001, NEW ENGL J MED, V345, P1583, DOI 10.1056/NEJMoa011090
   Carmeliet P, 1997, AM J PATHOL, V150, P761
   ESTERBAUER H, 1989, FREE RADICAL RES COM, V6, P67, DOI 10.3109/10715768909073429
   Francis GA, 2000, BBA-MOL CELL BIOL L, V1483, P217, DOI 10.1016/S1388-1981(99)00181-X
   Goldberg A, 2000, AM J CARDIOL, V85, P1100, DOI 10.1016/S0002-9149(00)00703-7
   Green PS, 2008, CIRCULATION, V118, P1259, DOI 10.1161/CIRCULATIONAHA.108.770669
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   HAVEL RJ, 1955, J CLIN INVEST, V34, P1345, DOI 10.1172/JCI103182
   Kleschyov AL, 2000, BIOCHEM BIOPH RES CO, V275, P672, DOI 10.1006/bbrc.2000.3361
   Krishna R, 2007, LANCET, V370, P1907, DOI 10.1016/S0140-6736(07)61813-3
   LAEMMLI UK, 1970, NATURE, V227, P680, DOI 10.1038/227680a0
   Landmesser U, 2003, J CLIN INVEST, V111, P1201, DOI 10.1172/JCI200314172
   Landmesser U, 2002, HYPERTENSION, V40, P511, DOI 10.1161/01.HYP.0000032100.23772.98
   Landmesser U, 2002, CIRCULATION, V106, P3073, DOI 10.1161/01.CIR.0000041431.57222.AF
   Landmesser U, 2004, CIRCULATION, V110, P1933, DOI 10.1161/01.CIR.0000143232.67642.7A
   Landmesser U, 2005, CIRCULATION, V111, P2356, DOI 10.1161/01.CIR.0000164260.82417.3F
   LINDNER V, 1993, CIRC RES, V73, P792, DOI 10.1161/01.RES.73.5.792
   Linke A, 2009, ATHEROSCLEROSIS, V205, P207, DOI 10.1016/j.atherosclerosis.2008.11.026
   Liu HR, 2009, CARDIOVASC RES, V81, P344, DOI 10.1093/cvr/cvn308
   Marsche G, 2008, CARDIOVASC RES, V79, P187, DOI 10.1093/cvr/cvn051
   MILLER NE, 1977, LANCET, V1, P965, DOI 10.1016/S0140-6736(77)92274-7
   NAGANO Y, 1991, P NATL ACAD SCI USA, V88, P6457, DOI 10.1073/pnas.88.15.6457
   Nicholls SJ, 2005, CIRCULATION, V111, P1543, DOI 10.1161/01.CIR.0000159351.95399.50
   Nissen SE, 2007, NEW ENGL J MED, V356, P1304, DOI 10.1056/NEJMoa070635
   NOBLE RP, 1968, J LIPID RES, V9, P693
   Nofer JR, 2004, J CLIN INVEST, V113, P569, DOI 10.1172/JCI200418004
   Persegol L, 2006, DIABETOLOGIA, V49, P1380, DOI 10.1007/s00125-006-0244-1
   Rader DJ, 2007, NAT CLIN PRACT CARD, V4, P102, DOI 10.1038/ncpcardio0768
   RIFICI VA, 1994, ATHEROSCLEROSIS, V107, P99, DOI 10.1016/0021-9150(94)90145-7
   Rohrer L, 2009, CIRC RES, V104, P1142, DOI 10.1161/CIRCRESAHA.108.190587
   Rubic T, 2004, BIOCHEM PHARMACOL, V67, P411, DOI 10.1016/j.bcp.2003.09.014
   Shao BH, 2008, P NATL ACAD SCI USA, V105, P12224, DOI 10.1073/pnas.0802025105
   Sorrentino SA, 2007, CIRCULATION, V116, P163, DOI 10.1161/CIRCULATIONAHA.106.684381
   Spieker LE, 2002, CIRCULATION, V105, P1399, DOI 10.1161/01.CIR.0000013424.28206.8F
   STEINBRECHER UP, 1987, J BIOL CHEM, V262, P3603
   Sumi M, 2007, ARTERIOSCL THROM VAS, V27, P813, DOI 10.1161/01.ATV.0000259299.38843.64
   Taylor AJ, 2004, CIRCULATION, V110, P3512, DOI 10.1161/01.CIR.0000148955.19792.8D
   Thum T, 2007, DIABETES, V56, P666, DOI 10.2337/db06-0699
   Tso C, 2006, ARTERIOSCL THROM VAS, V26, P1144, DOI 10.1161/01.ATV.0000216600.37436.cf
   Vita JA, 2004, CIRCULATION, V110, P1134, DOI 10.1161/01.CIR.0000140262.20831.8F
   Yuhanna IS, 2001, NAT MED, V7, P853, DOI 10.1038/89986
   Zhang ZL, 2001, JAMA-J AM MED ASSOC, V286, P2136, DOI 10.1001/jama.286.17.2136
   Zheng LM, 2004, J CLIN INVEST, V114, P529, DOI 10.1172/JCI200421109
NR 53
TC 333
Z9 353
U1 1
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD JAN 5
PY 2010
VL 121
IS 1
BP 110
EP 122
DI 10.1161/CIRCULATIONAHA.108.836346
PG 13
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 539PH
UT WOS:000273267700015
PM 20026785
OA Green Accepted, Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Nieto-Martinez, R
   De Oliveira-Gomes, D
   Gonzalez-Rivas, JP
   Al-Rousan, T
   Mechanick, JI
   Danaei, G
AF Nieto-Martinez, Ramfis
   De Oliveira-Gomes, Diana
   Gonzalez-Rivas, Juan P.
   Al-Rousan, Tala
   Mechanick, Jeffrey I.
   Danaei, Goodarz
TI Telehealth and cardiometabolic-based chronic disease: optimizing
   preventive care in forcibly displaced migrant populations
SO JOURNAL OF HEALTH POPULATION AND NUTRITION
LA English
DT Review
DE Cardiometabolic; Chronic Disease; Hypertension; Migrants; Preventive
   medicine; Telehealth; Type 2 diabetes
ID CLINICAL ENDOCRINOLOGISTS; AMERICAN ASSOCIATION; HEALTH-CARE; ADIPOSITY
AB The number of migrants, which includes forcibly displaced refugees, asylum seekers, and undocumented persons, is increasing worldwide. The global migrant population is heterogeneous in terms of medical conditions and vulnerability resulting from non-optimal metabolic risk factors in the country of origin (e.g., abnormal adiposity, dysglycemia, hypertension, and dyslipidemia), adverse travel conditions and the resulting stress, poverty, and anxiety, and varying effects of acculturation and access to healthcare services in the country of destination. Therefore, many of these migrants develop a high risk for cardiovascular disease and face the significant challenge of overcoming economic and health system barriers to accessing quality healthcare. In the host countries, healthcare professionals experience difficulties providing care to migrants, including cultural and language barriers, and limited institutional capacities, especially for those with non-legal status. Telehealth is an effective strategy to mitigate cardiometabolic risk factors primarily by promoting healthy lifestyle changes and pharmacotherapeutic adjustments. In this descriptive review, the role of telehealth in preventing the development and progression of cardiometabolic disease is explored with a specific focus on type 2 diabetes and hypertension in forcibly displaced migrants. Until now, there are few studies showing that culturally adapted telehealth services can decrease the burden of T2D and HTN. Despite study limitations, telehealth outcomes are comparable to those of traditional health care with the advantages of having better accessibility for difficult-to-reach populations such as forcibly displaced migrants and reducing healthcare associated costs. More prospective studies implementing telemedicine strategies to treat cardiometabolic disease burden in migrant populations are needed.
C1 [Nieto-Martinez, Ramfis] Precis Care Clin Corp, St Cloud, FL 34769 USA.
   [Nieto-Martinez, Ramfis; Gonzalez-Rivas, Juan P.; Danaei, Goodarz] Harvard TH Chan Sch Publ Hlth, Dept Global Hlth & Populat & Epidemiol, Boston, MA 02115 USA.
   [Nieto-Martinez, Ramfis; De Oliveira-Gomes, Diana; Gonzalez-Rivas, Juan P.] Fdn Clin Publ Hlth Epidemiol Res Venezuela FISPEVE, Caracas, Venezuela.
   [De Oliveira-Gomes, Diana] Univ Texas Southwestern Med Ctr, Dept Internal Med, Dallas, TX USA.
   [Gonzalez-Rivas, Juan P.] St Annes Univ Hosp Brno FNUSA, Int Clin Res Ctr ICRC, Brno, Czech Republic.
   [Al-Rousan, Tala] Univ Calif San Diego, Herbert Wertheim Sch Publ Hlth & Human Longev Sci, La Jolla, CA USA.
   [Mechanick, Jeffrey I.] Icahn Sch Med Mt Sinai, Marie Josee & Henry R Kravis Ctr Cardiovasc Hlth M, New York, NY USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health;
   University of Texas System; University of Texas Southwestern Medical
   Center Dallas; University of California System; University of California
   San Diego; Icahn School of Medicine at Mount Sinai
RP Nieto-Martinez, R (corresponding author), Precis Care Clin Corp, St Cloud, FL 34769 USA.; Nieto-Martinez, R (corresponding author), Harvard TH Chan Sch Publ Hlth, Dept Global Hlth & Populat & Epidemiol, Boston, MA 02115 USA.; Nieto-Martinez, R (corresponding author), Fdn Clin Publ Hlth Epidemiol Res Venezuela FISPEVE, Caracas, Venezuela.
EM nietoramfis@hsph.harvard.edu
RI Danaei, Goodarz/B-6085-2008; Gonzalez Rivas, Juan Pablo/HZK-6756-2023;
   Martinez, Andrea/KHX-0081-2024
OI De Oliveira, Diana/0000-0002-1207-1784; Danaei,
   Goodarz/0000-0003-2456-5463; Al-Rousan, Tala/0000-0001-8274-924X;
   mechanick, jeffrey/0000-0002-0657-588X; Nieto-Martinez,
   Ramfis/0000-0002-0575-7534
FU Not applicable.
FX Not applicable.
CR Abbas M, 2018, ANTIMICROB RESIST IN, V7, DOI 10.1186/s13756-018-0403-4
   Abubakar I, 2018, LANCET, V392, P2606, DOI 10.1016/S0140-6736(18)32114-7
   Al-Rousan T, 2022, INT J CARDIOL CARDIO, V12, DOI 10.1016/j.ijcrp.2022.200126
   Aldridge RW, 2018, LANCET, V392, P2553, DOI 10.1016/S0140-6736(18)32781-8
   Ben-Assuli O, 2022, INT J MED INFORM, V163, DOI 10.1016/j.ijmedinf.2022.104764
   Borsari L, 2018, J IMMIGR MINOR HEALT, V20, P1128, DOI 10.1007/s10903-017-0669-2
   Burke GV, 2023, TELEMED E-HEALTH, V29, P109, DOI 10.1089/tmj.2021.0597
   Choi TST, 2017, NUTR DIET, V74, P253, DOI 10.1111/1747-0080.12339
   de Kreutzenberg SV, 2022, HIGH BLOOD PRESS CAR, V29, P319, DOI 10.1007/s40292-022-00524-7
   Correia ETD, 2023, HEART FAIL REV, V28, P47, DOI 10.1007/s10741-022-10233-x
   Doraiswamy S, 2020, J MED INTERNET RES, V22, DOI 10.2196/24087
   Driscoll S, 2021, NUTRIENTS, V13, DOI 10.3390/nu13114078
   Fien S, 2022, PUBLIC HEALTH, V207, P119, DOI 10.1016/j.puhe.2022.04.007
   Foreman J, 2022, J HEALTH CARE POOR U, V33, P221, DOI 10.1353/hpu.2022.0017
   Garner SL, 2022, CIN-COMPUT INFORM NU, V40, P269, DOI 10.1097/CIN.0000000000000807
   Gonzalez-Rivas JP, 2021, OBES SCI PRACT, V7, P535, DOI 10.1002/osp4.496
   Gonzalez-Rivas JP, 2021, ENDOCR PRACT, V27, P455, DOI 10.1016/j.eprac.2020.10.003
   Hernández-Vásquez Akram, 2019, Rev. perú. med. exp. salud publica, V36, P583, DOI 10.17843/rpmesp.2019.360.4654
   Imai C, 2022, BJGP OPEN, V6, DOI 10.3399/BJGPO.2021.0200
   info, Plataforma de Coordinacion Interagencial para Refugiados y Migrantes de Venezuela
   Kavukcu N, 2019, PREHOSP DISASTER MED, V34, P188, DOI 10.1017/S1049023X19000190
   Kehlenbrink S, 2019, LANCET DIABETES ENDO, V7, P590, DOI 10.1016/S2213-8587(19)30197-4
   Kumar GS, 2021, J IMMIGR MINOR HEALT, V23, P813, DOI 10.1007/s10903-021-01146-2
   Kumar GS, 2020, PLOS MED, V17, DOI 10.1371/journal.pmed.1003118
   Kuziemsky Craig, 2019, Yearb Med Inform, V28, P35, DOI 10.1055/s-0039-1677897
   Lebano A, 2020, BMC PUBLIC HEALTH, V20, DOI 10.1186/s12889-020-08749-8
   Li Y, 2022, POPUL HEALTH MANAG, V25, P317, DOI 10.1089/pop.2021.0260
   Malacarne M, 2009, TELEMED J E-HEALTH, V15, P80, DOI 10.1089/tmj.2008.0066
   Mangrio E, 2017, BMC HEALTH SERV RES, V17, DOI 10.1186/s12913-017-2731-0
   Mechanick JI, 2020, J AM COLL CARDIOL, V75, P539, DOI 10.1016/j.jacc.2019.11.046
   Mechanick JI, 2020, J AM COLL CARDIOL, V75, P525, DOI 10.1016/j.jacc.2019.11.044
   Mechanick JI, 2017, ENDOCR PRACT, V23, P372, DOI 10.4158/EP161688.PS
   Mechanick JI, 2016, J AM COLL CARDIOL, V68, P1785, DOI 10.1016/j.jacc.2016.06.072
   Mechanick JL, 2018, ENDOCR PRACT, V24, P995, DOI 10.4158/PS-2018-0139
   Nieto-Martínez R, 2021, JPEN-PARENTER ENTER, V45, P85, DOI 10.1002/jpen.2264
   Nieto-Martínez R, 2018, ENDOCR PRACT, V24, P6, DOI 10.4158/EP161644.OR
   Nieto-Martínez R, 2016, ENDOCRIN METAB CLIN, V45, P967, DOI 10.1016/j.ecl.2016.06.002
   Nieto-Martinez RG-RJP., 2020, Creating a lifestyle medicine center
   Oni T, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-575
   Pavlovska I, 2021, ENDOCR PRACT, V27, P571, DOI 10.1016/j.eprac.2021.03.004
   Price M, 2013, J MED INTERNET RES, V15, DOI 10.2196/jmir.2500
   Reeves MM, 2021, NUTRIENTS, V13, DOI 10.3390/nu13114091
   Riza E, 2021, HEALTHCARE-BASEL, V9, DOI 10.3390/healthcare9101284
   Rosenthal T, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0872-0
   Sakakibara BM, 2022, INT J STROKE, V17, P455, DOI 10.1177/17474930211017699
   Sanabria TJ, 2012, TELEMED E-HEALTH, V18, P544, DOI 10.1089/tmj.2011.0192
   Santos DS, 2022, DIABETOL METAB SYNDR, V14, DOI 10.1186/s13098-022-00846-5
   Sapkota Sanjeeb, 2022, J Oral Biol Craniofac Res, V12, P299, DOI 10.1016/j.jobcr.2021.12.001
   Schrauben SJ, 2022, J RENAL NUTR, V32, P39, DOI 10.1053/j.jrn.2021.08.006
   Shahin W, 2021, ETHNIC HEALTH, V26, P756, DOI 10.1080/13557858.2018.1557118
   Silbermann Michael, 2016, J Glob Oncol, V2, P422, DOI 10.1200/JGO.2016.005173
   Söderström E, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19042328
   Suleman S, 2018, J PUBLIC HEALTH POL, V39, P407, DOI 10.1057/s41271-018-0140-1
   Suphanchaimat R, 2015, BMC HEALTH SERV RES, V15, DOI 10.1186/s12913-015-1065-z
   Tchang BG, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.793290
   The UN Refugee Agency, 2022, Refugee Data Finder
   Trummer U, 2017, EUR J PUBLIC HEALTH, V27, P590, DOI 10.1093/eurpub/ckx087
   United Nations Department of Economic and Social Affairs Population Division, 2019, International Migration 2019: Report (ST/ESA/SERA/438)
   Watt K, 2016, BMC FAM PRACT, V17, DOI 10.1186/s12875-016-0560-6
   Weller Sophie J, 2019, Wellcome Open Res, V4, P109, DOI 10.12688/wellcomeopenres.15358.1
   WHO, 2022, World Health Organization emergency appeal: Ukraine & refugee receiving and hosting countries
   who, 2019, Seventy-second World Health Assembly in May 2019. Promoting the health of refugees and migrants
   WHO. World Health Organization, 2022, Refugee and migrant health
NR 63
TC 3
Z9 4
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1606-0997
EI 2072-1315
J9 J HEALTH POPUL NUTR
JI J. Heatlh Popul. Nutr.
PD SEP 4
PY 2023
VL 42
IS 1
AR 93
DI 10.1186/s41043-023-00418-x
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA Q8AB4
UT WOS:001059684200001
PM 37667387
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Biganeh, J
   Kalantari, V
   Shekaftik, SO
   Sheikhmozafari, MJ
   Talebi, SS
   Ebrahimi, MH
AF Biganeh, Jamal
   Kalantari, Vanoushe
   Shekaftik, Soqrat Omari
   Sheikhmozafari, Mohammad Javad
   Talebi, Seyedeh Solmaz
   Ebrahimi, Mohammad Hossein
TI Assessment of Public Health Indicators Among Professional Drivers in
   Shahroud City: A Cross-Sectional Survey
SO JOURNAL OF HEALTH AND SAFETY AT WORK
LA English
DT Article
DE Professional driver; Driving; Public health; Accident
ID COMMERCIAL TRUCK DRIVERS; METABOLIC SYNDROME; PREVALENCE; STRESS; SLEEP;
   RELIABILITY; VALIDITY; VERSION
AB Introduction: Driving has various harmful factors due to its nature, which affect drivers' health directly and indirectly. Therefore, it is necessary to know the situation and prevalence of these factors in drivers to implement preventive measures. Material and Methods: This cross-sectional study is a part of a cohort study conducted (2016 to 2018) among the professional drivers of Shahroud, Iran. Data related to background information, blood pressure, performance indicators, sleep disorders, and accidents were collected from the participants with standard tools and methods. Results: This study examined 1461 male professional drivers with an average age of 37.30 +/- 6.96 years. A total of 426 participants had metabolic syndrome. 797 and 942 people had different degrees of hearing loss, respectively, in the right and left ear. About 129 people had obstructive sleep apnea, and 1330 people had insomnia. Investigations showed that 351 drivers had at least one accident. Conclusion: This study showed the prevalence of health risk factors in professional drivers at the examined time point. Considering the vital role of drivers in transportation and the country's economy, it seems necessary to pay more attention to the health of this occupational group. Regular health screening, healthy lifestyle training, improvement of working conditions, and stress management are some interventions that can effectively improve drivers' health.
C1 [Biganeh, Jamal; Shekaftik, Soqrat Omari; Sheikhmozafari, Mohammad Javad] Univ Tehran Med Sci, Sch Publ Hlth, Dept Occupat Hlth, Tehran, Iran.
   [Biganeh, Jamal; Ebrahimi, Mohammad Hossein] Shahroud Univ Med Sci, Environm & Occupat Hlth Res Ctr, Shahroud, Iran.
   [Kalantari, Vanoushe] Shahroud Univ Med Sci, Student Res Comm, Sch Med, Shahroud, Iran.
   [Shekaftik, Soqrat Omari] Univ Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran.
   [Talebi, Seyedeh Solmaz] Shahroud Univ Med Sci, Sch Publ Hlth, Dept Epidemiol, Shahroud, Iran.
C3 Tehran University of Medical Sciences; Shahroud University Medical
   Sciences; Shahroud University Medical Sciences; Tehran University of
   Medical Sciences; Shahroud University Medical Sciences
RP Ebrahimi, MH (corresponding author), Shahroud Univ Med Sci, Environm & Occupat Hlth Res Ctr, Shahroud, Iran.
EM ebrahimi_mh@hotmail.com
RI Omari Shekaftik, Soqrat/AHA-7280-2022; sheikhmozafari, mohammad
   javad/HLW-0578-2023; Biganeh, Jamal/IVH-5940-2023; Ebrahimi, Mohammad
   Hossein/I-3124-2017
OI Ebrahimi, Mohammad Hossein/0000-0002-1725-861X
CR Alahmari MD, 2019, TRAFFIC INJ PREV, V20, P498, DOI 10.1080/15389588.2019.1608975
   Anastasopoulos PC, 2012, ACCIDENT ANAL PREV, V45, P628, DOI 10.1016/j.aap.2011.09.015
   Arakawa T., 2017, J Institute Ind Appl Eng., V5, P136, DOI 10.12792/JIIAE.5
   Atanasovska A., 2023, Arch Public Health, V15, P16, DOI [10.3889/aph.2023.6091, DOI 10.3889/APH.2023.6091]
   Bacon SL, 2004, SPORTS MED, V34, P307, DOI 10.2165/00007256-200434050-00003
   Bhatti JA, 2016, TRAFFIC INJ PREV, V17, P604, DOI 10.1080/15389588.2015.1134793
   Cunningham ML, 2016, ROAD TRANSP RES, V25, P40
   Dalton Brian H., 2007, Occupational Ergonomics, V7, P143
   Delhomme P, 2021, J SAFETY RES, V79, P341, DOI 10.1016/j.jsr.2021.10.001
   Ford ES, 2003, DIABETES CARE, V26, P575, DOI 10.2337/diacare.26.3.575
   Gallegos-Gonzalez G, 2021, AM J HEALTH BEHAV, V45, P1091, DOI 10.5993/AJHB.45.6.12
   Garbarino S, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15091852
   Pasandi HG, 2022, INT J OCCUP SAF ERGO, V28, P1994, DOI 10.1080/10803548.2021.1943154
   Guest AJ, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2020-038993
   Guglielmi O, 2018, SOC PSYCH PSYCH EPID, V53, P531, DOI 10.1007/s00127-017-1474-x
   Haghighi KS, 2013, SLEEP BREATH, V17, P419, DOI 10.1007/s11325-012-0646-x
   Han TS, 2016, JRSM CARDIOVASC DIS, V5, DOI 10.1177/2048004016633371
   Harith SH, 2019, P INT C IND ENG OP M
   Heidari A, 2010, Women Cult Sci Res Q
   Izadi N, 2021, J DIABETES METAB DIS, V20, P2015, DOI 10.1007/s40200-021-00928-7
   Joewono TB, 2021, SUSTAINABILITY-BASEL, V13, DOI 10.3390/su131910834
   Joseph L, 2023, HUM FACTORS, V65, P62, DOI 10.1177/00187208211006500
   Joseph L, 2020, J OCCUP HEALTH, V62, DOI 10.1002/1348-9585.12150
   Kim SJ, 2019, J SAFETY RES, V68, P27, DOI 10.1016/j.jsr.2018.11.001
   Kwon S, 2019, J TRANSP HEALTH, V14, DOI 10.1016/j.jth.2019.100572
   Luzzi V, 2022, J CLIN MED, V11, DOI 10.3390/jcm11143971
   Mabry JE, 2016, J TRANSP HEALTH, V3, P413, DOI 10.1016/j.jth.2016.06.012
   Mohammadiyan M., 2023, Int. J. Environ. Health Eng., V12, P6
   Mohebbi I, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031790
   Moturi WO, 2019, Food choices as an occupation hazard: Food choice and purchase behavior among long-haul truck drivers
   Nam JY, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-3617-5
   Pourabdian S, 2020, J OCCUP HEALTH, V62, DOI 10.1002/1348-9585.12114
   Rahmani R, 2022, HELIYON, V8, DOI 10.1016/j.heliyon.2022.e10329
   Rivero-Yeverino Daniela, 2019, Rev. alerg. Méx., V66, P76, DOI 10.29262/ram.v66i1.536
   Robbins RB, 2020, J OCCUP ENVIRON MED, V62, P453, DOI 10.1097/JOM.0000000000001863
   Sadeghniiat-Haghighi K, 2015, QUAL LIFE RES, V24, P2025, DOI 10.1007/s11136-015-0923-9
   Schiza SE, 2020, BREATHE, V16, DOI 10.1183/20734735.0364-2019
   Sekhon NK, 2020, INT J AUDIOL, V59, P948, DOI 10.1080/14992027.2020.1780485
   Serrano-Fernández MJ, 2019, J TRANSP HEALTH, V14, DOI 10.1016/j.jth.2019.100576
   Sharwood LN, 2011, J AUSTRALAS COLL ROA, V22, P24
   Stern HS, 2019, ACCIDENT ANAL PREV, V126, P37, DOI 10.1016/j.aap.2018.02.021
   Syndrome Components by WHO E IDF III N-A., Int J Res Med.
   Thorslund B, 2014, Effects of hearing loss on traffic safety and mobility
   Unger T, 2020, J HYPERTENS, V38, P982, DOI [10.1097/HJH.0000000000002453, 10.1161/HYPERTENSIONAHA.120.15026]
   Wang XM, 2021, PHYSIOL BEHAV, V229, DOI 10.1016/j.physbeh.2020.113247
   Wong RY, 2023, CUREUS J MED SCIENCE, V15, DOI 10.7759/cureus.41186
   World Health Organization, Hearing impairment grades.
   Yau YHC, 2013, MINERVA ENDOCRINOL, V38, P255
   Yazdi Z, 2012, MALAYS J MED SCI, V19, P31
NR 49
TC 0
Z9 0
U1 1
U2 1
PU IRANIAN OCCUPATIONAL HEALTH ASSOC
PI TEHRAN
PA DEPT OCCUPATIONAL HEALTH, SCH PUBLIC HEALTH, PO BOX 13155-119, TEHRAN,
   00000, IRAN
SN 2251-807X
EI 2383-2088
J9 J HEALTH SAF WORK
JI J. Health Saf. Work
PY 2024
VL 14
IS 2
BP 349
EP 366
PG 18
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA YH6K4
UT WOS:001267634800007
DA 2025-06-11
ER

PT J
AU Trzepizur, W
   Khalyfa, A
   Qiao, ZH
   Popko, B
   Gozal, D
AF Trzepizur, Wojciech
   Khalyfa, Abdelnaby
   Qiao, Zhuanhong
   Popko, Brian
   Gozal, David
TI Integrated stress response activation by sleep fragmentation during late
   gestation in mice leads to emergence of adverse metabolic phenotype in
   offspring
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Gestational sleep fragmentation; Integrated stress response; Metabolic
   syndrome; Insulin-resistance; Exosomes
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE;
   INSULIN-RESISTANCE; ADIPOSE-TISSUE; OBESITY; DEPRIVATION; DISORDERS;
   EXOSOMES; HOMEOSTASIS; DYSFUNCTION
AB Background. Late gestational sleep fragmentation (SF) is highly prevalent particularly in obese women, and induces metabolic dysfunction in adult offspring mice. SF induces activation of the integrated stress response (ISR), which might be involved in metabolic disorders. We hypothesized that adult offspring of double mutant mice (DM) involving the critical ISR genes CHOP and GADD34 would be protected from developing obesity and insulin resistance following SF.
   Methods. Time-pregnant CHOP/GADD34 DM and wild type (WT) mice were randomly assigned to sleep control (SC) or SF conditions during the last 5 days of gestation. At 24-weeks of age, body weight, fat mass, and HOMA-IR were assessed in the offspring. Tregs lymphocytes, Lyc6c(high), M1 and M2 macrophages were examined in visceral white adipose tissues (vWAT) using flow cytometry. The effects of plasma exosomes on adipocyte cell line proliferation, differentiation and insulin sensitivity were also evaluated.
   Results. SF-WT male showed significant increases in body weight, vWAT mass and HOMA-IR compared to SC-WT mice, while SF had no effect in SF-DM mice. Inflammatory macrophages (Ly-6c(high)) and the ratio of MI/M2 macrophages were increased while FoxP3+ Tregs counts were decreased in SF-WT but not in SF-DM mice. Exosomes from SF-WT, but not from the SF-DM offspring increased pre-adipocyte proliferation and differentiation, and decreased in vitro adipocyte insulin sensitivity.
   Conclusion. Activation of the ISR during late gestation, as induced by late gestational SF, appears to underlie some of the transgenerational modifications in metabolic genes ultimately contributing to a metabolic syndrome phenotype in adult offspring. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Trzepizur, Wojciech; Khalyfa, Abdelnaby; Qiao, Zhuanhong; Gozal, David] Univ Chicago, Div Biol Sci, Sect Sleep Med, Dept Pediat,Pritzker Sch Med, Chicago, IL 60637 USA.
   [Popko, Brian] Univ Chicago, Univ Chicago Ctr Peripheral Neuropathy, Dept Neurol, Chicago, IL 60637 USA.
C3 University of Chicago; University of Chicago
RP Gozal, D (corresponding author), Univ Chicago, Pritzker Sch Med, Dept Pediat, Sect Pediat Sleep Med,KCBD, Room 4100 900 E 57th St,Mailbox 4, Chicago, IL 60637 USA.
EM dgozal@uchicago.edu
RI Gozal, David/ABH-3805-2020; qiao, Zhuanhong/A-1117-2009; Khalyfa,
   Abdelnaby/M-9498-2017
OI Popko, Brian/0000-0001-9948-2553
FU Le Fonds de Dotation "Recherche en Sante Respiratoire" et La Fondation
   du Souffle; National Institutes of Health [NS034939]; Herbert T. Abelson
   Chair
FX d WT was supported by grants from Le Fonds de Dotation "Recherche en
   Sante Respiratoire" et La Fondation du Souffle. BP is supported by
   National Institutes of Health NS034939. This study was supported by the
   Herbert T. Abelson Chair to DG.
CR Calegare BFA, 2010, PSYCHONEUROENDOCRINO, V35, P775, DOI 10.1016/j.psyneuen.2009.11.004
   [Anonymous], 2011, NCHS DATA BRIEF
   Aswad H, 2014, DIABETOLOGIA, V57, P2155, DOI 10.1007/s00125-014-3337-2
   Basseri S, 2012, BIOCHEM RES INT, V2012, DOI 10.1155/2012/841362
   Bourjeily G, 2011, CLIN CHEST MED, V32, P175, DOI 10.1016/j.ccm.2010.11.003
   Chen L, 2014, HEPATOLOGY, V59, P1118, DOI 10.1002/hep.26768
   Cortese R, 2015, INT J OBESITY, V39, P1135, DOI 10.1038/ijo.2015.38
   Edgar JR, 2016, BMC BIOL, V14, DOI 10.1186/s12915-016-0268-z
   Elshenawy S, 2016, MOL CELL ENDOCRINOL, V435, P2, DOI 10.1016/j.mce.2016.07.002
   Flegal KM, 2010, JAMA-J AM MED ASSOC, V303, P235, DOI 10.1001/jama.2009.2014
   Ghigliotti G, 2014, INFLAMMATION, V37, P1337, DOI 10.1007/s10753-014-9914-1
   Hakim F, 2015, SLEEP, V38, P31, DOI 10.5665/sleep.4320
   Hasnain SZ, 2016, J MOL ENDOCRINOL, V56, pR33, DOI 10.1530/JME-15-0232
   Hutchison BL, 2012, BMC PREGNANCY CHILDB, V12, DOI 10.1186/1471-2393-12-144
   Kapsimalis F, 2009, J WOMENS HEALTH, V18, P1211, DOI 10.1089/jwh.2008.1054
   Khalyfa A., 2016, AM J RESP CRIT CARE
   Khalyfa A, 2016, ONCOTARGET, V7, P54676, DOI 10.18632/oncotarget.10578
   Khalyfa A, 2014, DIABETES, V63, P3230, DOI 10.2337/db14-0202
   Klieser E, 2015, ANTICANCER RES, V35, P6127
   Kojima E, 2003, FASEB J, V17, P1573, DOI 10.1096/fj.02-1184fje
   Li J, 2012, J HEPATOL, V56, P900, DOI 10.1016/j.jhep.2011.10.018
   Lumeng CN, 2007, DIABETES, V56, P16, DOI 10.2337/db06-1076
   Lumeng CN, 2007, J CLIN INVEST, V117, P175, DOI 10.1172/JCI29881
   Luque-Fernandez MA, 2013, DIABETES CARE, V36, P3353, DOI 10.2337/dc13-0778
   Mans M., 2012, DIABETOLOGIA, V55, P1167, DOI DOI 10.1007/S00195-011-2427-7
   Marciniak SJ, 2004, GENE DEV, V18, P3066, DOI 10.1101/gad.1250704
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mutskov V, 2015, AM J PHYSIOL-REG I, V308, pR419, DOI 10.1152/ajpregu.00426.2014
   Naidoo N, 2005, J NEUROCHEM, V92, P1150, DOI 10.1111/j.1471-4159.2004.02952.x
   Naidoo N, 2008, J NEUROSCI, V28, P6539, DOI 10.1523/JNEUROSCI.5685-07.2008
   Naidoo N, 2014, AGING CELL, V13, P131, DOI 10.1111/acel.12158
   Nair D, 2011, AM J RESP CRIT CARE, V184, P1305, DOI 10.1164/rccm.201107-1173OC
   Nicholas LM, 2016, INT J OBESITY, V40, P229, DOI 10.1038/ijo.2015.178
   Nishio N, 2015, SCI REP-UK, V5, DOI 10.1038/srep13519
   O'Brien LM, 2013, SLEEP, V36, P1625, DOI 10.5665/sleep.3112
   O'Keeffe M, 2013, INT J OBESITY, V37, P765, DOI 10.1038/ijo.2012.142
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Ramesh V, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-91
   Sahota PK, 2003, CURR OPIN PULM MED, V9, P477, DOI 10.1097/00063198-200311000-00005
   Simmons R, 2008, SEMIN PERINATOL, V32, P371, DOI 10.1053/j.semperi.2008.08.004
   Srivastava SP, 1998, J BIOL CHEM, V273, P2416, DOI 10.1074/jbc.273.4.2416
   van 't Wout EFA, 2014, AM J RESP CELL MOL, V50, P1005, DOI 10.1165/rcmb.2014-0019TR
   Winer S, 2009, NAT MED, V15, P921, DOI 10.1038/nm.2001
   Yang JY, 2014, BIOMARK RES, V2, DOI 10.1186/2050-7771-2-1
   Yung HW, 2016, DIABETOLOGIA, V59, P2240, DOI 10.1007/s00125-016-4040-2
   Zhu Y, 2008, J NEUROSCI, V28, P2168, DOI 10.1523/JNEUROSCI.5232-07.2008
NR 46
TC 18
Z9 18
U1 0
U2 10
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD APR
PY 2017
VL 69
BP 188
EP 198
DI 10.1016/j.metabol.2017.01.026
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EP9MN
UT WOS:000397697800020
PM 28139216
DA 2025-06-11
ER

PT J
AU Afifi, AHM
   El-Bitar, HI
   Ahmed, MA
AF Afifi, Abdel-Halim M.
   El-Bitar, Hussein I.
   Ahmed, Marwa A.
TI EVALUATION OF POTENTIAL PROTECTIVE EFFECTS OF CURCUMIN VERSUS METFORMIN
   IN EXPERIMENTALLY-INDUCED METABOLIC SYNDROME IN RATS
SO BULLETIN OF PHARMACEUTICAL SCIENCES
LA English
DT Article
AB Metabolic syndrome (MetSyn) is the clustering of various interrelated risk factors of metabolic origin that increased incidence of cardiovascular diseases and type 2 diabetes. In this study the effectiveness of curcumin was evaluated in comparison with metformin in fructose-induced MetSyn disease in rats. Fructose was fed (10% solution in drinking water) for 8 weeks during which groups of rats were administered once daily vehicle (2% carboxy methyl cellulose), curcumin (40 and 80 mg/kg), metformin (100 and 200 mg/kg), their combinations and compared with group received tap water instead of fructose. The results revealed that induction of MetSyn was associated with glucose intolerance, insulin resistance alongside with increased weights of body and visceral fats. This was accompanied with an elevation of arterial blood pressure. Meanwhile, it caused disturbances in lipid profile (triglyceride, total cholesterol, HDL-C and LDL-C) and both oxidative stress (malondialdehyde, 8-iso-PGF(2 alpha) and superoxide dismutase) and inflammatory status (tumor necrosis factor-alpha interleukin-6, C-reactive protein and adiponectin) parameters. Each of curcumin and metformin significantly prevents, to variable extents, the progression of most of these signs of MetSyn. Furthermore, the efficacy of each of the two drugs in question was significantly augmented upon their concurrent administration. These protective effects of the two drugs under investigation presumably may be relevant to their ability to reduce the oxidative stress and to ameliorate the inflammatory processes.
C1 [Afifi, Abdel-Halim M.; El-Bitar, Hussein I.; Ahmed, Marwa A.] Assiut Univ, Dept Pharmacol, Fac Med, Assiut 71526, Egypt.
C3 Egyptian Knowledge Bank (EKB); Assiut University
RP Ahmed, MA (corresponding author), Assiut Univ, Dept Pharmacol, Fac Med, Assiut 71526, Egypt.
EM marwaabdelraheim@yahoo.com
CR Abdullah MM, 2007, LIPIDS, V42, P855, DOI 10.1007/s11745-007-3096-7
   Aggarwal BB, 2009, TRENDS PHARMACOL SCI, V30, P85, DOI 10.1016/j.tips.2008.11.002
   Aggarwal BB, 2009, INT J BIOCHEM CELL B, V41, P40, DOI 10.1016/j.biocel.2008.06.010
   de Artiñano AA, 2009, BRIT J NUTR, V102, P1246, DOI 10.1017/S0007114509990729
   Arita Y, 1999, BIOCHEM BIOPH RES CO, V257, P79, DOI 10.1006/bbrc.1999.0255
   Bagatini MD, 2011, HEART VESSELS, V26, P55, DOI 10.1007/s00380-010-0029-9
   BERNARDIS LL, 1968, J ENDOCRINOL, V40, P527, DOI 10.1677/joe.0.0400527
   Bonnefont-Rousselot A., 2003, METABOLISM, V52, P58
   Busserolles J, 2002, BRIT J NUTR, V87, P337, DOI 10.1079/BJNBJN2002524
   Caballero AE, 2004, J CLIN ENDOCR METAB, V89, P3943, DOI 10.1210/jc.2004-0019
   Chattopadhyay I, 2004, CURR SCI INDIA, V87, P44
   Cool B, 2006, CELL METAB, V3, P403, DOI 10.1016/j.cmet.2006.05.005
   DAI S, 1995, J PHARMACOL TOX MET, V33, P101, DOI 10.1016/1056-8719(94)00063-A
   Ejaz A, 2009, J NUTR, V139, P919, DOI 10.3945/jn.108.100966
   Evans JL, 2005, ANTIOXID REDOX SIGN, V7, P1040, DOI 10.1089/ars.2005.7.1040
   Faizal P, 2009, INDIAN J CLIN BIOCHE, V24, P82, DOI 10.1007/s12291-009-0014-1
   Festing Michael F W, 2002, ILAR J, V43, P244
   Fontbonne A, 2009, DIABETES METAB, V35, P385, DOI 10.1016/j.diabet.2009.03.005
   GIUGLIANO D, 1993, EUR J CLIN PHARMACOL, V44, P107, DOI 10.1007/BF00315466
   Gomez-Garcia A, 2007, REV ESP CARDIOL, V60, P1242, DOI 10.1157/13113929
   Gunton JE, 2003, J CLIN ENDOCR METAB, V88, P1323, DOI 10.1210/jc.2002-021394
   Gupta SC, 2011, NAT PROD REP, V28, P1937, DOI 10.1039/c1np00051a
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Houston MC, 2009, PROG CARDIOVASC DIS, V52, P61, DOI 10.1016/j.pcad.2009.02.002
   Johansen K, 1999, DIABETES CARE, V22, P33, DOI 10.2337/diacare.22.1.33
   Kahn C R, 1979, Diabetes Care, V2, P283
   Katakam PVG, 2000, HYPERTENSION, V35, P108, DOI 10.1161/01.HYP.35.1.108
   Khan SH, 2007, PAK J MED SCI, V23, P903
   Kusaka I, 2008, DIABETES OBES METAB, V10, P1039, DOI 10.1111/j.1463-1326.2008.00857.x
   Lin JG, 2011, MOL CELL ENDOCRINOL, V333, P160, DOI 10.1016/j.mce.2010.12.028
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mlinar B, 2007, CLIN CHIM ACTA, V375, P20, DOI 10.1016/j.cca.2006.07.005
   Moller DE, 2005, ANNU REV MED, V56, P45, DOI 10.1146/annurev.med.56.082103.104751
   Na LX, 2011, NUTR METAB CARDIOVAS, V21, P526, DOI 10.1016/j.numecd.2009.11.009
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   Ouchi N, 2000, CIRCULATION, V102, P1296, DOI 10.1161/01.CIR.102.11.1296
   Ouslimani N, 2005, METABOLISM, V54, P829, DOI 10.1016/j.metabol.2005.01.029
   Owen MR, 2000, BIOCHEM J, V348, P607, DOI 10.1042/0264-6021:3480607
   Pauline M., 2011, Al Ameen Journal of Medical Sciences, V4, P365
   Raso GM, 2009, EUR J PHARMACOL, V604, P125, DOI 10.1016/j.ejphar.2008.12.013
   Ridker PM, 2000, NEW ENGL J MED, V342, P836, DOI 10.1056/NEJM200003233421202
   Rungseesantivanon S, 2010, BMC COMPLEM ALTERN M, V10, DOI 10.1186/1472-6882-10-57
   Schultes B, 2003, J CLIN ENDOCR METAB, V88, P1133, DOI 10.1210/jc.2002-021450
   Seo KI, 2008, MOL NUTR FOOD RES, V52, P995, DOI 10.1002/mnfr.200700184
   SHANKAR P, 2003, JIACM, V4, P275
   Singh U., 2010, FREE RADIC RES, V45
   Soudamini K. K., 1992, Indian Journal of Physiology and Pharmacology, V36, P239
   Sugiura K, 2008, INT J CARDIOL, V130, P159, DOI 10.1016/j.ijcard.2008.01.006
   Tacconelli S, 2010, METHODS MOL BIOL, V644, P165, DOI 10.1007/978-1-59745-364-6_14
   Tappy L, 2010, PHYSIOL REV, V90, P23, DOI 10.1152/physrev.00019.2009
   TRINDER P, 1969, J CLIN PATHOL, V22, P158, DOI 10.1136/jcp.22.2.158
   Usharani P, 2008, DRUGS R&D, V9, P243, DOI 10.2165/00126839-200809040-00004
   Verma S, 1999, EUR J PHARMACOL, V373, pR1, DOI 10.1016/S0014-2999(99)00301-5
   Waki H, 2007, ANNU REV PATHOL-MECH, V2, P31, DOI 10.1146/annurev.pathol.2.010506.091859
   Wulffelé MG, 2004, J INTERN MED, V256, P1, DOI 10.1111/j.1365-2796.2004.01328.x
NR 55
TC 0
Z9 0
U1 1
U2 2
PU ASSIUT UNIV, FAC PHARMACY
PI ASSIUT
PA C/O DR SAMYA M EL-SAYED, ASSIUT, 00000, EGYPT
SN 1110-0052
J9 B PHARM SCI
JI Bull. Pharm. Sci.
PD DEC
PY 2014
VL 37
BP 77
EP 90
PN 2
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA V47BR
UT WOS:000209927800002
DA 2025-06-11
ER

PT J
AU Benjamin, S
   Prakasan, P
   Sreedharan, S
   Wright, ADG
   Spener, F
AF Benjamin, Sailas
   Prakasan, Priji
   Sreedharan, Sajith
   Wright, Andre-Denis G.
   Spener, Friedrich
TI Pros and cons of CLA consumption: an insight from clinical evidences
SO NUTRITION & METABOLISM
LA English
DT Review
DE Conjugated linoleic acids; CLA; Review; Clinical evidences
ID CONJUGATED LINOLEIC-ACID; C-REACTIVE PROTEIN; REDUCES BODY-FAT;
   POSTMENOPAUSAL BREAST-CANCER; LIPID PROFILE; WEIGHT-LOSS; INSULIN
   SENSITIVITY; METABOLIC SYNDROME; GENE-EXPRESSION; IMMUNE FUNCTION
AB This comprehensive review critically evaluates whether supposed health benefits propounded upon human consumption of conjugated linoleic acids (CLAs) are clinically proven or not. With a general introduction on the chemistry of CLA, major clinical evidences pertaining to intervention strategies, body composition, cardio-vascular health, immunity, asthma, cancer and diabetes are evaluated. Supposed adverse effects such as oxidative stress, insulin resistance, irritation of intestinal tract and milk fat depression are also examined. It seems that no consistent result was observed even in similar studies conducted at different laboratories, this may be due to variations in age, gender, racial and geographical disparities, coupled with type and dose of CLA supplemented. Thus, supposed promising results reported in mechanistic and pre-clinical studies cannot be extrapolated with humans, mainly due to the lack of inconsistency in analyses, prolonged intervention studies, follow-up studies and international co-ordination of concerted studies. Briefly, clinical evidences accumulated thus far show that CLA is not eliciting significantly promising and consistent health effects so as to uphold it as neither a functional nor a medical food.
C1 [Benjamin, Sailas; Prakasan, Priji; Sreedharan, Sajith] Univ Calicut, Div Biotechnol, Dept Bot, Technol Enzymat Lab, Calicut 673635, Kerala, India.
   [Wright, Andre-Denis G.] Univ Arizona, Sch Anim & Comparat Biomed Sci, Tucson, AZ 85721 USA.
   [Spener, Friedrich] Graz Univ, Dept Mol Biosci, A-8010 Graz, Austria.
C3 University of Calicut; University of Arizona; University of Graz
RP Benjamin, S (corresponding author), Univ Calicut, Div Biotechnol, Dept Bot, Technol Enzymat Lab, Calicut 673635, Kerala, India.
EM benjamin@uoc.ac.in
RI WRIGHT, ANDRE-DENIS/ABI-2584-2020
FU Department of Biotechnology (DBT), Ministry of Science and Technology,
   Government of India [BT/PR 12714/FNS/20/411/2009]
FX The authors gratefully acknowledge the Department of Biotechnology
   (DBT), Ministry of Science and Technology, Government of India, for a
   research grant (No. BT/PR 12714/FNS/20/411/2009).
CR Adams Roger E, 2006, J Int Soc Sports Nutr, V3, P28, DOI 10.1186/1550-2783-3-2-28
   Albers R, 2003, EUR J CLIN NUTR, V57, P595, DOI 10.1038/sj.ejcn.1601585
   Alonso L, 2003, J DAIRY SCI, V86, P1941, DOI 10.3168/jds.S0022-0302(03)73781-3
   [Anonymous], 1999, CHARACTER AGR L
   Aro A, 2000, NUTR CANCER, V38, P151, DOI 10.1207/S15327914NC382_2
   Atkinson RL, 1999, ADVANCES IN CONJUGATED LINOLEIC ACID RESEARCH, VOL 1, P348
   Basu S, 2000, CLIN SCI, V99, P511, DOI [10.1042/CS20000116, 10.1042/cs0990511]
   Basu S, 2000, FEBS LETT, V468, P33, DOI 10.1016/S0014-5793(00)01193-5
   Bauman D. E., 2003, Advances in conjugated linoleic acid research, volume 2, P146
   Bauman D.E., 2000, J ANIM SCI, V77, P1, DOI [DOI 10.2527/JAS2000.77E-SUPPL1F, 10.2527/jas2000.77ESuppl1f]
   Baumgard LH, 2001, J NUTR, V131, P1764, DOI 10.1093/jn/131.6.1764
   Benito P, 2001, LIPIDS, V36, P229, DOI 10.1007/s11745-001-0712-x
   Benjamin S, 2005, EUR J LIPID SCI TECH, V107, P706, DOI 10.1002/ejlt.200401041
   Benjamin S, 2013, J ZHEJIANG UNIV-SC B, V14, P115, DOI 10.1631/jzus.B1200175
   Benjamin S, 2009, NUTR METAB, V6, DOI 10.1186/1743-7075-6-36
   Berven G, 2000, EUR J LIPID SCI TECH, V102, P455, DOI 10.1002/1438-9312(200008)102:7<455::AID-EJLT455>3.0.CO;2-V
   Bhattacharya A, 2006, J NUTR BIOCHEM, V17, P789, DOI 10.1016/j.jnutbio.2006.02.009
   Blankson H, 2000, J NUTR, V130, P2943, DOI 10.1093/jn/130.12.2943
   Borg P, 2002, INT J OBESITY, V26, P676, DOI 10.1038/sj.ijo.0801962
   Bray GA, 2004, J CLIN ENDOCR METAB, V89, P2583, DOI 10.1210/jc.2004-0535
   Brown A, 2008, THESIS IOWA STATE U, P89
   Butler G, 2011, J DAIRY SCI, V94, P24, DOI 10.3168/jds.2010-3331
   CADE J, 1991, BRIT J GEN PRACT, V41, P147
   Caroprese M, 2010, J DAIRY SCI, V93, P2580, DOI 10.3168/jds.2008-2003
   Chajès V, 2003, NUTR CANCER, V45, P17, DOI 10.1207/S15327914NC4501_2
   Chajès V, 2002, CANCER EPIDEM BIOMAR, V11, P672
   Chen CA, 1998, J ORG CHEM, V63, P9620, DOI 10.1021/jo981905m
   Chen SC, 2012, NUTRITION, V28, P559, DOI 10.1016/j.nut.2011.09.008
   Choi YJ, 2000, J NUTR, V130, P1920, DOI 10.1093/jn/130.8.1920
   Christie W. W., 2003, Advances in conjugated linoleic acid research, volume 2, P1
   Close RN, 2007, AM J CLIN NUTR, V86, P797, DOI 10.1093/ajcn/86.3.797
   Cornish SM, 2009, INT J SPORT NUTR EXE, V19, P79, DOI 10.1123/ijsnem.19.1.79
   DEFRONZO RA, 1979, AM J PHYSIOL, V237, pE214
   Dehghan A, 2007, DIABETES CARE, V30, P2695, DOI 10.2337/dc07-0348
   DELORGERIL M, 1994, LANCET, V343, P1454, DOI 10.1016/S0140-6736(94)92580-1
   Desroches S, 2005, AM J CLIN NUTR, V82, P309, DOI 10.1093/ajcn/82.2.309
   Devillard E, 2007, J BACTERIOL, V189, P2566, DOI 10.1128/JB.01359-06
   Dhiman TR, 2000, J DAIRY SCI, V83, P1016, DOI 10.3168/jds.S0022-0302(00)74966-6
   Dobson G., 2003, Advances in conjugated linoleic acid research, volume 2, P13
   Eyjolfson V, 2004, MED SCI SPORT EXER, V36, P814, DOI 10.1249/01.MSS.0000126391.42896.31
   Gaullier JM, 2007, BRIT J NUTR, V97, P550, DOI 10.1017/S0007114507381324
   Gaullier JM, 2005, J NUTR, V135, P778
   Gaullier JM, 2002, LIPIDS, V37, P1019, DOI 10.1007/s11745-002-0995-y
   Gaullier JM, 2004, AM J CLIN NUTR, V79, P1118
   Gelone S, 2010, PRINCIPLES GOOD CLIN, P91
   Griinari JM, 2000, J NUTR, V130, P2285, DOI 10.1093/jn/130.9.2285
   HA YL, 1987, CARCINOGENESIS, V8, P1881, DOI 10.1093/carcin/8.12.1881
   Halliwell B, 2007, BIOCHEM J, V401, P1, DOI 10.1042/BJ20061131
   Hasin A, 2007, LIPIDS, V42, P835, DOI 10.1007/s11745-007-3086-9
   Henriksen EJ, 2003, AM J PHYSIOL-ENDOC M, V285, pE98, DOI 10.1152/ajpendo.00013.2003
   Herrera JA, 2006, AM J HYPERTENS, V19, P381, DOI 10.1016/j.amjhyper.2005.11.004
   Hoffmann K, 2005, LIPIDS, V40, P309, DOI 10.1007/s11745-005-1387-z
   Hommelberg PPH, 2010, MOL NUTR FOOD RES, V54, P1763, DOI 10.1002/mnfr.201000103
   Hu FB, 1999, AM J CLIN NUTR, V69, P890
   Hunter DJ, 1996, NEW ENGL J MED, V334, P356, DOI 10.1056/NEJM199602083340603
   Ivan M, 2013, BR J NUTR, V1, P1
   Jaudszus A, 2005, BBA-MOL CELL BIOL L, V1737, P111, DOI 10.1016/j.bbalip.2005.11.001
   Jenkins NDM, 2014, J STRENGTH COND RES, V28, P2127, DOI 10.1519/JSC.0000000000000513
   Joseph SV, 2011, J NUTR, V141, P1286, DOI 10.3945/jn.110.135087
   Kamphuis MMJW, 2003, EUR J CLIN NUTR, V57, P1268, DOI 10.1038/sj.ejcn.1601684
   Kamphuis MMJW, 2003, INT J OBESITY, V27, P840, DOI 10.1038/sj.ijo.0802304
   Kang JX, 1996, CIRCULATION, V94, P1774, DOI 10.1161/01.CIR.94.7.1774
   Katzman MA, 2007, LIPIDS HEALTH DIS, V6, DOI 10.1186/1476-511X-6-14
   Kelley DS, 2001, LIPIDS, V36, P669, DOI 10.1007/s11745-001-0771-z
   Kelley DS, 2000, LIPIDS, V35, P1065, DOI 10.1007/s11745-000-0620-0
   Kelsey JA, 2003, J DAIRY SCI, V86, P2588, DOI 10.3168/jds.S0022-0302(03)73854-5
   Kim J.-H., 2008, Prev Nutr Food Sci, V13, P146, DOI DOI 10.3746/JFN.2008.13.3.146
   Kraft J, 2003, LIPIDS, V38, P657, DOI 10.1007/s11745-003-1111-z
   Kreider RB, 2002, J STRENGTH COND RES, V16, P325
   Kritchevsky D, 2004, LIPIDS, V39, P611, DOI 10.1007/s11745-004-1273-8
   Kuhnt K, 2009, EUR J LIPID SCI TECH, V111, P442, DOI 10.1002/ejlt.200800217
   Lai KL, 2005, LIPIDS, V40, P1107, DOI 10.1007/s11745-005-1474-1
   Lamarche B, 2004, AM J CLIN NUTR, V79, p1149S, DOI 10.1093/ajcn/79.6.1149S
   Lambert EV, 2007, BRIT J NUTR, V97, P1001, DOI 10.1017/S0007114507172822
   LARSON BL, 1950, J DAIRY SCI, V33, P896, DOI 10.3168/jds.S0022-0302(50)91987-4
   Larsson SC, 2005, AM J CLIN NUTR, V82, P894, DOI 10.1093/ajcn/82.4.894
   Larsson SC, 2009, AM J CLIN NUTR, V90, P556, DOI 10.3945/ajcn.2009.27480
   Laso N, 2007, BRIT J NUTR, V98, P860, DOI 10.1017/S0007114507750882
   Lock AL, 2004, J NUTR, V134, P2698, DOI 10.1093/jn/134.10.2698
   Macaluso F, 2012, J STRENGTH COND RES, V26, P1667, DOI 10.1519/JSC.0b013e318231ab78
   MacRedmond R, 2010, CLIN EXP ALLERGY, V40, P1071, DOI 10.1111/j.1365-2222.2010.03531.x
   Malpuech-Brugère C, 2004, OBES RES, V12, P591, DOI 10.1038/oby.2004.68
   Masters N, 2002, LIPIDS, V37, P133, DOI 10.1007/s11745-002-0872-8
   McCann SE, 2004, CANCER EPIDEM BIOMAR, V13, P1480
   McGuire M.A., 2000, J ANIM SCI, V77, P1, DOI DOI 10.2527/JAS2000.00218812007700ES0033X
   McLeod RS, 2004, AM J CLIN NUTR, V79, p1169S, DOI 10.1093/ajcn/79.6.1169S
   Medina EA, 2000, LIPIDS, V35, P783, DOI 10.1007/s11745-000-0586-y
   Moloney F, 2004, AM J CLIN NUTR, V80, P887
   Mosley SA, 2007, LIPIDS, V42, P723, DOI 10.1007/s11745-007-3087-8
   Mougios V, 2001, J NUTR BIOCHEM, V12, P585, DOI 10.1016/S0955-2863(01)00177-2
   Nazare JA, 2007, BRIT J NUTR, V97, P273, DOI 10.1017/S0007114507191911
   Nicolosi RJ, 1997, ARTERY, V22, P266
   Noone EJ, 2002, BRIT J NUTR, V88, P243, DOI 10.1079/BJN2002615
   Norris LE, 2009, AM J CLIN NUTR, V90, P468, DOI 10.3945/ajcn.2008.27371
   Nugent AP, 2005, EUR J CLIN NUTR, V59, P742, DOI 10.1038/sj.ejcn.1602132
   O'Donnell-Megaro AM, 2011, J DAIRY SCI, V94, P59, DOI 10.3168/jds.2010-3571
   Ode JJ, 2007, MED SCI SPORT EXER, V39, P403, DOI 10.1249/01.mss.0000247008.19127.3e
   OWEN S, 1991, NEW ENGL J MED, V325, P586
   Pariza MW, 2001, PROG LIPID RES, V40, P283, DOI 10.1016/S0163-7827(01)00008-X
   Park Y, 1999, LIPIDS, V34, P243, DOI 10.1007/s11745-999-0359-7
   Patel HJ, 2003, J IMMUNOL, V170, P2663, DOI 10.4049/jimmunol.170.5.2663
   Penedo LA, 2013, J NUTR BIOCHEM, V24, P2144, DOI 10.1016/j.jnutbio.2013.08.006
   Petridou A, 2003, LIPIDS, V38, P805, DOI 10.1007/s11745-003-1129-2
   Pfeuffer M, 2011, J AM COLL NUTR, V30, P19, DOI 10.1080/07315724.2011.10719940
   Pinkoski C, 2006, MED SCI SPORT EXER, V38, P339, DOI 10.1249/01.mss.0000183860.42853.15
   Pintus S, 2013, BRIT J NUTR, V109, P1453, DOI 10.1017/S0007114512003224
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Racine NM, 2010, AM J CLIN NUTR, V91, P1157, DOI 10.3945/ajcn.2009.28404
   Raff M, 2009, J NUTR, V139, P1347, DOI 10.3945/jn.109.104471
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   Risérus U, 2004, AM J CLIN NUTR, V80, P279
   Risérus U, 2004, DIABETOLOGIA, V47, P1016, DOI 10.1007/s00125-004-1421-8
   Risérus U, 2002, DIABETES CARE, V25, P1516, DOI 10.2337/diacare.25.9.1516
   Risérus U, 2002, CIRCULATION, V106, P1925, DOI 10.1161/01.CIR.0000033589.15413.48
   Rist L, 2007, BRIT J NUTR, V97, P735, DOI 10.1017/S0007114507433074
   Gutiérrez GR, 2009, GRASAS ACEITES, V60, P28, DOI 10.3989/gya.086308
   Rosberg-Cody E, 2004, APPL ENVIRON MICROB, V70, P4635, DOI 10.1128/AEM.70.8.4635-4641.2004
   Ryder JW, 2001, DIABETES, V50, P1149, DOI 10.2337/diabetes.50.5.1149
   Shadman Z, 2013, J DIABETES METAB DIS, V12, DOI 10.1186/2251-6581-12-42
   Shahar E, 2003, STROKE, V34, P623, DOI 10.1161/01.STR.0000057812.51734.FF
   Sluijs I, 2010, AM J CLIN NUTR, V91, P175, DOI 10.3945/ajcn.2009.28192
   Smedman A, 2005, BRIT J NUTR, V94, P791, DOI 10.1079/BJN20041419
   Sneddon AA, 2008, OBESITY, V16, P1019, DOI 10.1038/oby.2008.41
   Song HJ, 2005, EUR J CLIN NUTR, V59, P508, DOI 10.1038/sj.ejcn.1602102
   St-Onge MP, 2004, J GERONTOL A-BIOL, V59, P796
   Stanton C., 2003, Advances in conjugated linoleic acid research, volume 2, P123
   Steck SE, 2007, J NUTR, V137, P1188, DOI 10.1093/jn/137.5.1188
   Stickford JL, 2011, INT J SPORT NUTR EXE, V21, P40, DOI 10.1123/ijsnem.21.1.40
   Syvertsen C, 2007, INT J OBESITY, V31, P1148, DOI 10.1038/sj.ijo.0803482
   Tajmanesh M., 2014, Razi Journal of Medical Sciences, V20, P45
   Tarnopolsky MA, 2008, APPL PHYSIOL NUTR ME, V33, P213, DOI 10.1139/H07-142
   Tholstrup T, 2008, J NUTR, V138, P1445, DOI 10.1093/jn/138.8.1445
   Thom E, 2001, J INT MED RES, V29, P392, DOI 10.1177/147323000102900503
   Tricon S, 2006, AM J CLIN NUTR, V83, P744, DOI 10.1093/ajcn/83.4.744
   Tricon S, 2004, AM J CLIN NUTR, V80, P1626, DOI 10.1093/ajcn/80.6.1626
   Tricon S, 2004, AM J CLIN NUTR, V80, P614
   Turpeinen AM, 2002, AM J CLIN NUTR, V76, P504, DOI 10.1093/ajcn/76.3.504
   Vemuri M, 2010, NUTR HEALTH SER, P133, DOI 10.1007/978-1-60327-571-2_9
   Venkatramanan S, 2010, J AM COLL NUTR, V29, P152, DOI 10.1080/07315724.2010.10719829
   Voorrips LE, 2002, AM J CLIN NUTR, V76, P873, DOI 10.1093/ajcn/76.4.873
   Wanders AJ, 2010, FOOD CHEM TOXICOL, V48, P587, DOI 10.1016/j.fct.2009.11.036
   Wang Y, 2013, BRIT J NUTR, V110, P1369, DOI 10.1017/S0007114513001086
   Watras AC, 2007, INT J OBESITY, V31, P481, DOI 10.1038/sj.ijo.0803437
   Whigham LD, 2004, FOOD CHEM TOXICOL, V42, P1701, DOI 10.1016/j.fct.2004.06.008
   Whigham LD, 2002, AM J PHYSIOL-REG I, V282, pR1104, DOI 10.1152/ajpregu.00075.2001
   Whigham LD, 2001, AM J PHYSIOL-REG I, V280, pR908, DOI 10.1152/ajpregu.2001.280.3.R908
   Whigham LD, 2000, PHARMACOL RES, V42, P503, DOI 10.1006/phrs.2000.0735
   Yang TS, 2004, J AGR FOOD CHEM, V52, P5079, DOI 10.1021/jf0401017
   Zambell KL, 2000, LIPIDS, V35, P777, DOI 10.1007/s11745-000-0585-z
   Zlatanos SN, 2008, LIPIDS HEALTH DIS, V7, DOI 10.1186/1476-511X-7-34
NR 150
TC 89
Z9 92
U1 0
U2 55
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD FEB 3
PY 2015
VL 12
AR 4
DI 10.1186/1743-7075-12-4
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CC6SZ
UT WOS:000350500000001
PM 25972911
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Machado, FVC
   Pitta, F
   Hernandes, NA
   Bertolini, GL
AF Cavallari Machado, Felipe Vilaca
   Pitta, Fabio
   Hernandes, Nidia Aparecida
   Bertolini, Gisele Lopes
TI Physiopathological relationship between chronic obstructive pulmonary
   disease and insulin resistance
SO ENDOCRINE
LA English
DT Review
DE Pulmonary disease; Chronic obstructive; Insulin resistance; Diabetes
   mellitus; Risk factors
ID METABOLIC SYNDROME; INHALED CORTICOSTEROIDS; DIABETES-MELLITUS;
   CIGARETTE-SMOKING; PHYSICAL-ACTIVITY; SYSTEMIC INFLAMMATION;
   GLUCOSE-TOLERANCE; OXIDATIVE STRESS; LIPID-METABOLISM; SKELETAL-MUSCLE
AB Chronic obstructive pulmonary disease (COPD) is characterized by persistent and progressive airflow obstruction that is associated with an abnormal chronic inflammatory response in the airways and lungs to noxious particles. COPD often leads to physical inactivity and deconditioning that added to inappropriate/excessive inflammatory responses leads to systemic consequences. Studies have shown that metabolic syndrome and manifested diabetes are more frequent in COPD than in healthy subjects; a possible explanation is that different pathophysiological aspects of COPD can lead to insulin resistance. Thus, this mini-review aims to present the main studies suggesting a pathophysiological relationship between COPD and insulin resistance.
   A review of literature was conducted using PubMed and Web of Science databases with the aim of searching for studies supporting a relationship between COPD and insulin resistance.
   A physiopathological relationship between COPD and insulin resistance was found, supported in part due to common risk factors presented by these two conditions, such as smoking and physical inactivity. Also, systemic effects (worsening of physical inactivity and sedentary behavior, inflammation and oxidative stress, body composition abnormalities) and the corticosteroid treatment of patients with COPD may play a role.
   Patients with COPD should be screened for abnormalities in insulin sensitivity in order to reduce morbidity and improve health status in this population.
C1 [Cavallari Machado, Felipe Vilaca; Pitta, Fabio; Hernandes, Nidia Aparecida] State Univ Londrina UEL, Dept Physiotherapy, Lab Res Resp Physiotherapy LFIP, Londrina, Parana, Brazil.
   [Bertolini, Gisele Lopes] State Univ Londrina UEL, Dept Physiol Sci, Londrina, Parana, Brazil.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina
RP Bertolini, GL (corresponding author), State Univ Londrina UEL, Dept Physiol Sci, Londrina, Parana, Brazil.
EM giselebertolini@uel.br
RI Bertolini, Gisele/LZI-2896-2025; Hernandes, Nidia/AAY-9196-2021; Pitta,
   Fabio/D-7875-2013; Machado, Felipe/AAA-7851-2020
OI Pitta, Fabio/0000-0002-3369-6660; Lopes Bertolini,
   Gisele/0000-0002-0161-937X; Machado, Felipe/0000-0003-1910-7695
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES),
   Brazil
FX Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES),
   Brazil.
CR Arciero PJ, 1998, J APPL PHYSIOL, V84, P1365, DOI 10.1152/jappl.1998.84.4.1365
   Barnes PJ, 2009, EUR RESPIR J, V33, P1165, DOI 10.1183/09031936.00128008
   Barnes PJ, 2016, J ALLERGY CLIN IMMUN, V138, P16, DOI 10.1016/j.jaci.2016.05.011
   Beijers RJHCG, 2017, J AM MED DIR ASSOC, V18, P533, DOI 10.1016/j.jamda.2016.12.081
   Bergman BC, 2012, DIABETES, V61, P3156, DOI 10.2337/db12-0418
   Blackburn D, 2002, J GEN INTERN MED, V17, P717, DOI 10.1046/j.1525-1497.2002.10649.x
   Bolton C E, 2007, COPD, V4, P121, DOI 10.1080/15412550701341053
   Borst SE, 2004, ENDOCRINE, V23, P177, DOI 10.1385/ENDO:23:2-3:177
   Castro AAM, 2012, CLINICS, V67, P319, DOI 10.6061/clinics/2012(04)04
   Cena H, 2013, DIABETOL METAB SYNDR, V5, DOI 10.1186/1758-5996-5-28
   Dendukuri N, 2002, BRIT J CLIN PHARMACO, V54, P59, DOI 10.1046/j.1365-2125.2002.01610.x
   Dennis RJ, 2010, BMC PULM MED, V10, DOI 10.1186/1471-2466-10-38
   FACCHINI FS, 1992, LANCET, V339, P1128, DOI 10.1016/0140-6736(92)90730-Q
   Frati AC, 1996, DIABETES CARE, V19, P112, DOI 10.2337/diacare.19.2.112
   Geer EB, 2014, ENDOCRIN METAB CLIN, V43, P75, DOI 10.1016/j.ecl.2013.10.005
   Gläser S, 2015, RESPIRATION, V89, P253, DOI 10.1159/000369863
   Global Initiative for Chronic Obstructive Lung Disease (GOLD), 2017, GLOBAL STRATEGY DIAG
   Goossens GH, 2008, PHYSIOL BEHAV, V94, P206, DOI 10.1016/j.physbeh.2007.10.010
   Green HJ, 2008, J APPL PHYSIOL, V105, P879, DOI 10.1152/japplphysiol.90458.2008
   Hamburg N. M., 2008, ARTERIOSCL THROM VAS, V27, P2650
   Hernandes NA, 2009, J BRAS PNEUMOL, V35, P949, DOI 10.1590/S1806-37132009001000002
   Ijiri N, 2015, RESPIROLOGY, V20, P612, DOI 10.1111/resp.12513
   Joppa P, 2016, J AM MED DIR ASSOC, V17, P712, DOI 10.1016/j.jamda.2016.03.020
   Keane KN, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/181643
   Kirkham PA, 2013, CHEST, V144, P266, DOI 10.1378/chest.12-2664
   Lavie L, 2009, EUR RESPIR J, V33, P1467, DOI 10.1183/09031936.00086608
   Lawlor DA, 2004, DIABETOLOGIA, V47, P195, DOI 10.1007/s00125-003-1310-6
   Lipovec NC, 2016, COPD, V13, P399, DOI 10.3109/15412555.2016.1140732
   Lira VA, 2010, AM J PHYSIOL-ENDOC M, V299, pE145, DOI 10.1152/ajpendo.00755.2009
   Maltais F, 2014, AM J RESP CRIT CARE, V189, P1121, DOI 10.1164/rccrn.201402-0373ST
   Manson JE, 2000, AM J MED, V109, P538, DOI 10.1016/S0002-9343(00)00568-4
   Minas M, 2011, COPD, V8, P414, DOI 10.3109/15412555.2011.619600
   Miranda PJ, 2005, AM HEART J, V149, P33, DOI 10.1016/j.ahj.2004.07.013
   Niewoehner DE, 1999, NEW ENGL J MED, V340, P1941, DOI 10.1056/NEJM199906243402502
   O'Byrne PM, 2012, RESP MED, V106, P1487, DOI 10.1016/j.rmed.2012.07.011
   Park KH, 2013, J CLIN ENDOCR METAB, V98, P4899, DOI 10.1210/jc.2013-2373
   Park SK, 2014, J CARDIOVASC NURS, V29, P499, DOI 10.1097/JCN.0000000000000096
   Pedersen BK, 2012, NAT REV ENDOCRINOL, V8, P457, DOI 10.1038/nrendo.2012.49
   Piazzolla G, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0186708
   Pitta F, 2005, AM J RESP CRIT CARE, V171, P972, DOI 10.1164/rccm.200407-855OC
   Saltiel AR, 2001, NATURE, V414, P799, DOI 10.1038/414799a
   Schäcke H, 2002, PHARMACOL THERAPEUT, V96, P23, DOI 10.1016/S0163-7258(02)00297-8
   Singh S, 2016, AM J PHYSIOL-LUNG C, V310, pL837, DOI 10.1152/ajplung.00091.2015
   Smorawinski J, 2000, J PHYSIOL PHARMACOL, V51, P279
   Spranger J, 2003, DIABETES, V52, P812, DOI 10.2337/diabetes.52.3.812
   Spruit MA, 2013, AM J RESP CRIT CARE, V188, pE13, DOI 10.1164/rccm.201309-1634ST
   STUART CA, 1988, METABOLISM, V37, P802, DOI 10.1016/0026-0495(88)90018-2
   Suissa S, 2010, AM J MED, V123, P1001, DOI 10.1016/j.amjmed.2010.06.019
   Sun K, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047791
   Velloso M, 2013, INT J CHRONIC OBSTR, V8, P187, DOI 10.2147/COPD.S36606
   Vorrink SNW, 2011, RESP RES, V12, DOI 10.1186/1465-9921-12-33
   Wada T, 2007, INTERNAL MED, V46, P1079, DOI 10.2169/internalmedicine.46.0026
   Watz H, 2009, CHEST, V136, P1039, DOI 10.1378/chest.09-0393
   Wells CE, 2016, RESPIROLOGY, V21, P689, DOI 10.1111/resp.12716
   Willi C, 2007, JAMA-J AM MED ASSOC, V298, P2654, DOI 10.1001/jama.298.22.2654
NR 55
TC 31
Z9 31
U1 0
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD JUL
PY 2018
VL 61
IS 1
BP 17
EP 22
DI 10.1007/s12020-018-1554-z
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GJ2UQ
UT WOS:000435129400004
PM 29512058
DA 2025-06-11
ER

PT J
AU Venkatesan, V
   Madhira, SL
   Malakapalli, VM
   Chalasani, M
   Shaik, SN
   Seshadri, V
   Kodavalla, V
   Bhonde, RR
   Nappanveettil, G
AF Venkatesan, Vijayalakshmi
   Madhira, Soundarya L.
   Malakapalli, Venkata M.
   Chalasani, Maniprabha
   Shaik, Sarfaraz N.
   Seshadri, Vasudevan
   Kodavalla, Venkaiah
   Bhonde, Ramesh R.
   Nappanveettil, Giridharan
TI Obesity, Insulin Resistance, and Metabolic Syndrome: A Study in WNIN/Ob
   Rats from a Pancreatic Perspective
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; DIABETIC FATTY RATS; BETA-CELL MASS;
   OXIDATIVE STRESS; GENE-EXPRESSION; ANIMAL-MODELS; ISLET; SECRETION;
   LEPTIN; INFLAMMATION
AB Alterations in pancreatic milieu to adapt to physiological shifts occurring in conditions of obesity and metabolic syndrome (MS) have been documented, though mechanisms leading to such a state have remained elusive so far. The data presented here tries to look at the gravity of metabolic insult during the early and prolonged phases of obesity/insulin resistance (IR) depicted in WNIN/Ob strain of rats-an obese euglycemic mutant rat model developed indigenously at our institute which is highly vulnerable for a variety of degenerative diseases. The present results in situ show the participation of several confounding factors in the pancreatic milieu that collectively coprecipitates for a state of profound inflammation in the pancreas (among Mutant compared to Lean/Control) which gets worsened with age. These include hypertrophy, macrophage infiltration (CD11b/TNF alpha/IL6), apoptosis, beta-cell vacuolation, hyperinsulinemia (HI), and stressmarkers (RL-77/HSP104/TBARS) all of which correlated well with indices for obesity (2-3 fold), IR (1.5-3 fold), and HI (2-3 fold). Further, supportive data was also obtained from in vitro studies using islet cell cultures amongst phenotypes. Taken together, these results advocate that inflammation was the major precipitating factor to cause islet cell dysfunctions (in situ and in vitro) in these Mutant rats compared to their Lean littermates and parental Control.
C1 [Venkatesan, Vijayalakshmi; Madhira, Soundarya L.; Malakapalli, Venkata M.; Chalasani, Maniprabha; Shaik, Sarfaraz N.] Indian Council Med Res, Natl Inst Nutr, Dept Biochem Stem Cell Res, Hyderabad 500007, Andhra Pradesh, India.
   [Seshadri, Vasudevan] Natl Ctr Cell Sci, Lab 12, Pune 411007, Maharashtra, India.
   [Kodavalla, Venkaiah] Natl Inst Nutr, Div Community Studies, Hyderabad 500007, Andhra Pradesh, India.
   [Bhonde, Ramesh R.] Manipal Inst Regenerat Med, Bangalore 560065, Karnataka, India.
   [Nappanveettil, Giridharan] Natl Inst Nutr, Natl Ctr Lab Anim Sci, Hyderabad 500007, Andhra Pradesh, India.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute of
   Nutrition (NIN); Department of Biotechnology (DBT) India; National
   Centre for Cell Science, Pune (NCCS); Indian Council of Medical Research
   (ICMR); ICMR - National Institute of Nutrition (NIN); Manipal Academy of
   Higher Education (MAHE); Indian Council of Medical Research (ICMR); ICMR
   - National Institute of Nutrition (NIN); ICMR - National Animal Resource
   Facility for Biomedical Research (NARFBR)
RP Venkatesan, V (corresponding author), Indian Council Med Res, Natl Inst Nutr, Dept Biochem Stem Cell Res, Jamai Osmania PO, Hyderabad 500007, Andhra Pradesh, India.
EM v.venkateshan@gmail.com
RI BHONDE, RAMESH/C-1233-2009; Nawaz, Sarfaraz/N-8784-2019
OI Venkatesan, Vijayalakhsmi/0000-0002-3142-9657; Nawaz, Shaik
   Sarfaraz/0000-0002-2606-4112
FU National Institute of Nutrition, Indian Council of Medical Research,
   Hyderabad
FX The authors wish to thank the Director of the National Institute of
   Nutrition, Indian Council of Medical Research (Flagship Project),
   Hyderabad, for extending grant support to execute this work. They also
   thank Dr. NV Giridharan and Dr. P Suresh, the former and present,
   respectively, person in charge of NCLAS, for extending support to carry
   out the animal experiments. They deeply acknowledge help extended by Dr.
   P. Uday Kumar (Pathology Head) and his team for providing them with
   tissue sections.
CR Alemzadeh R, 2004, ENDOCRINOLOGY, V145, P5476, DOI 10.1210/en.2003-1523
   Amoli MM, 2005, CYTOTECHNOLOGY, V48, P75, DOI 10.1007/s10616-005-3586-5
   [Anonymous], 2011, ISRN ENDOCRINOL
   Bandaru P., 2013, ENDOCRINOL METAB, V2, P116
   Bandaru P, 2011, VACCINE, V29, P3038, DOI 10.1016/j.vaccine.2011.01.107
   Bastard JP, 2006, EUR CYTOKINE NETW, V17, P4
   Cefalu WT, 2006, ILAR J, V47, P186, DOI 10.1093/ilar.47.3.186
   Chairmandurai A., 2010, GASTROENTEROLOGY RES, V3, P1918
   Challa SS, 2011, TISSUE CELL, V43, P266, DOI 10.1016/j.tice.2011.03.007
   CHEN NG, 1993, J NUTR, V123, P1567, DOI 10.1093/jn/123.9.1567
   Chentouf M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0022954
   Cnop M, 2005, DIABETES, V54, pS97, DOI 10.2337/diabetes.54.suppl_2.S97
   Cui YF, 2005, WORLD J GASTROENTERO, V11, P545, DOI 10.3748/wjg.v11.i4.545
   Cunha DA, 2008, J CELL SCI, V121, P2308, DOI 10.1242/jcs.026062
   De Rosa V, 2007, IMMUNITY, V26, P241, DOI 10.1016/j.immuni.2007.01.011
   Ding YL, 2010, EXP BIOL MED, V235, P40, DOI 10.1258/ebm.2009.009100
   Donath MY, 2010, TRENDS ENDOCRIN MET, V21, P261, DOI 10.1016/j.tem.2009.12.010
   Donath MY, 2009, PHYSIOLOGY, V24, P325, DOI 10.1152/physiol.00032.2009
   Dorisetty RK, 2008, WORLD J GASTROENTERO, V14, P7112, DOI 10.3748/wjg.14.7112
   Dussault AA, 2006, BIOL PROCED ONLINE, V8, P1, DOI 10.1251/bpo114
   Ehses JA, 2007, DIABETES, V56, P2356, DOI 10.2337/db06-1650
   Finegood DT, 2001, DIABETES, V50, P1021, DOI 10.2337/diabetes.50.5.1021
   Giridharan N. V., 2010, P CMJ J, V96
   Giridharan NV, 1998, INDIAN J MED RES, V108, P225
   Gobe Glenda, 2009, V466, P175, DOI 10.1007/978-1-59745-352-3_13
   Harishankar N, 2011, INDIAN J MED RES, V134, P330
   Hemalatha Rajkumar P.B., 2013, Endocrinol. Metab. Syndr, DOI [10.4172/2161-1017.1000113, DOI 10.4172/2161-1017.1000113]
   Hsieh CH, 2006, INDIAN J MED RES, V124, P527
   Kalashikam RR, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0077679
   Kaneko K, 2010, CELL METAB, V12, P619, DOI 10.1016/j.cmet.2010.11.005
   Kaneto H, 2009, ADV DRUG DELIVER REV, V61, P489, DOI 10.1016/j.addr.2008.12.015
   Kaufman RJ, 2010, DIABETES OBES METAB, V12, P99, DOI 10.1111/j.1463-1326.2010.01281.x
   Kawamori D, 2003, DIABETES, V52, P2896, DOI 10.2337/diabetes.52.12.2896
   Kewalramani G, 2010, CURR OPIN CLIN NUTR, V13, P382, DOI 10.1097/MCO.0b013e32833aabd9
   Kikkawa R, 2000, BRIT J NUTR, V84, pS183
   Kim HE, 2008, J ENDOCRINOL, V198, P549, DOI 10.1677/JOE-08-0131
   Kiran SG, 2011, EXP BIOL MED, V236, P456, DOI 10.1258/ebm.2011.010361
   Kristiansen OP, 2005, DIABETES, V54, pS114, DOI 10.2337/diabetes.54.suppl_2.S114
   Lipson KL, 2006, CELL METAB, V4, P245, DOI 10.1016/j.cmet.2006.07.007
   Madhira SL, 2011, MOL CELL BIOCHEM, V357, P217, DOI 10.1007/s11010-011-0892-4
   Madhira SL, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048061
   Mishima K, 2000, P NATL ACAD SCI USA, V97, P8484, DOI 10.1073/pnas.150239497
   Mitsuhashi T, 2011, JACC-CARDIOVASC IMAG, V4, P392, DOI 10.1016/j.jcmg.2011.02.004
   Nieman DC, 1996, INT J OBESITY, V20, P353
   Nugent DA, 2008, TOXICOL PATHOL, V36, P529, DOI 10.1177/0192623308318209
   O'Shea D, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008660
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Procaccini C, 2012, MOL ASPECTS MED, V33, P35, DOI 10.1016/j.mam.2011.10.012
   Qatanani M, 2007, GENE DEV, V21, P1443, DOI 10.1101/gad.1550907
   Quan W, 2012, EXP MOL MED, V44, P81, DOI 10.3858/emm.2012.44.2.030
   Reddy GB, 2009, INVEST OPHTH VIS SCI, V50, P3456, DOI 10.1167/iovs.08-2498
   Roma LP, 2012, DIABETOLOGIA, V55, P2226, DOI 10.1007/s00125-012-2581-6
   Rui LY, 2001, J CLIN INVEST, V107, P181, DOI 10.1172/JCI10934
   Saisho Y, 2013, DIABETES CARE, V36, P111, DOI 10.2337/dc12-0421
   Sánchez-Pozo C, 2003, CLIN EXP IMMUNOL, V134, P464, DOI 10.1111/j.1365-2249.2003.02321.x
   Seufert J, 2004, DIABETES, V53, pS152, DOI 10.2337/diabetes.53.2007.S152
   Singotamu L, 2005, Scanning, V27, P160
   Tataranni PA, 2005, DIABETES, V54, P917, DOI 10.2337/diabetes.54.4.917
   Thanumalayan S., 2008, Indian Journal of Veterinary Pathology, V32, P242
   Üçkaya G, 2005, J ENDOCRINOL, V184, P505, DOI 10.1677/joe.1.05818
   Venkatesan V, 2012, CYTOTECHNOLOGY, V64, P139, DOI 10.1007/s10616-011-9409-y
   Vijayalakshmi V, 1997, BIOCHEM MOL BIOL INT, V43, P1041
   Vincent HK, 2006, INT J OBESITY, V30, P400, DOI 10.1038/sj.ijo.0803177
   Wang DH, 2010, IEEE PEDG 2010: THE 2ND INTERNATIONAL SYMPOSIUM ON POWER ELECTRONICS FOR DISTRIBUTED GENERATION SYSTEMS, P1, DOI 10.1109/PEDG.2010.5545769
   Wellen KE, 2003, J CLIN INVEST, V112, P1785, DOI 10.1172/JCI20514
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
NR 66
TC 18
Z9 18
U1 0
U2 2
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT-UK
JI Biomed Res. Int.
PY 2013
VL 2013
AR 617569
DI 10.1155/2013/617569
PG 19
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 280KK
UT WOS:000329028200001
PM 24455710
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Kolb, H
   Mandrup-Poulsen, T
AF Kolb, H.
   Mandrup-Poulsen, T.
TI The global diabetes epidemic as a consequence of lifestyle-induced
   low-grade inflammation
SO DIABETOLOGIA
LA English
DT Review
DE Beta cell; Cytokines; Inflammation; Insulin resistance; Lifestyle;
   Macrophage; Pathogenesis; Review; Type 2 diabetes
ID C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA; FACTOR-KAPPA-B; INDUCED
   INSULIN-RESISTANCE; SKELETAL-MUSCLE CELLS; WHITE ADIPOSE-TISSUE;
   HIGH-FAT-DIET; HEALTHY-SUBJECTS; BETA-CELLS; METABOLIC SYNDROME
AB The recent major increase in the global incidence of type 2 diabetes suggests that most cases of this disease are caused by changes in environment and lifestyle. All major risk factors for type 2 diabetes (overnutrition, low dietary fibre, sedentary lifestyle, sleep deprivation and depression) have been found to induce local or systemic low-grade inflammation that is usually transient or milder in individuals not at risk for type 2 diabetes. By contrast, inflammatory responses to lifestyle factors are more pronounced and prolonged in individuals at risk of type 2 diabetes and appear to occur also in the pancreatic islets. Chronic low-grade inflammation will eventually lead to overt diabetes if counter-regulatory circuits to inflammation and metabolic stress are compromised because of a genetic and/or epigenetic predisposition. Hence, it is not the lifestyle change per se but a deficient counter-regulatory response in predisposed individuals which is crucial to disease pathogenesis. Novel approaches of intervention may target these deficient defence mechanisms.
C1 [Kolb, H.; Mandrup-Poulsen, T.] Hagedorn Res Inst, DK-2820 Gentofte, Denmark.
   [Mandrup-Poulsen, T.] Univ Copenhagen, Fac Hlth Sci, Inst Biomed Sci, Ctr Med Res Methodol, Copenhagen, Denmark.
   [Mandrup-Poulsen, T.] Karolinska Inst, Dept Med & Surg, Stockholm, Sweden.
C3 Novo Nordisk; Hagedorn Research Institute; University of Copenhagen;
   Karolinska Institutet
RP Kolb, H (corresponding author), Hagedorn Res Inst, DK-2820 Gentofte, Denmark.
EM hubert.kolb@gmx.com
OI Mandrup-Poulsen, Thomas/0000-0002-3215-9273
CR Aarnes M, 2002, BIOCHEM BIOPH RES CO, V296, P189, DOI 10.1016/S0006-291X(02)00819-7
   Aksentijevich I, 2009, NEW ENGL J MED, V360, P2426, DOI 10.1056/NEJMoa0807865
   Aljada A, 2004, AM J CLIN NUTR, V79, P682
   [Anonymous], DTSCH GESUNDHEITSBER
   Arkan MC, 2005, NAT MED, V11, P191, DOI 10.1038/nm1185
   Beasley LE, 2009, OBESITY, V17, P1062, DOI 10.1038/oby.2008.627
   Berchtold LA, 2009, EUR CYTOKINE NETW, V20, P81, DOI 10.1684/ecn.2009.0152
   Blackburn P, 2006, OBESITY, V14, P1747, DOI 10.1038/oby.2006.201
   Böni-Schnetzler M, 2008, J CLIN ENDOCR METAB, V93, P4065, DOI 10.1210/jc.2008-0396
   Burkart V, 2002, J IMMUNOL, V168, P1730, DOI 10.4049/jimmunol.168.4.1730
   Cai DS, 2005, NAT MED, V11, P183, DOI 10.1038/nm1166
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Chandalia M, 2003, J CLIN ENDOCR METAB, V88, P3773, DOI 10.1210/jc.2003-030301
   Channual J, 2009, DERMATOL THER, V22, P61, DOI 10.1111/j.1529-8019.2008.01217.x
   Chao W, 2009, AM J PHYSIOL-HEART C, V296, pH1, DOI 10.1152/ajpheart.00995.2008
   Cheung D, 2009, J AM ACAD DERMATOL, V60, P1032, DOI 10.1016/j.jaad.2008.12.012
   Clément K, 2004, FASEB J, V18, P1657, DOI 10.1096/fj.04-2204com
   Dasu MR, 2008, DIABETES, V57, P3090, DOI 10.2337/db08-0564
   Dasu MR, 2007, AM J PHYSIOL-ENDOC M, V293, pE337, DOI 10.1152/ajpendo.00718.2006
   Devaraj S, 2005, DIABETES, V54, P85, DOI 10.2337/diabetes.54.1.85
   Dickinson S, 2008, AM J CLIN NUTR, V87, P1188
   Donath MY, 2008, ENDOCR REV, V29, P334, DOI 10.1210/er.2007-0033
   El-Osta A, 2008, J EXP MED, V205, P2409, DOI 10.1084/jem.20081188
   Esposito K, 2003, AM J CLIN NUTR, V78, P1135, DOI 10.1093/ajcn/78.6.1135
   Esposito K, 2002, CIRCULATION, V106, P2067, DOI 10.1161/01.CIR.0000034509.14906.AE
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   Fernández-Real JM, 2008, J CLIN ENDOCR METAB, V93, P2523, DOI 10.1210/jc.2007-1212
   Fleischman A, 2008, DIABETES CARE, V31, P289, DOI 10.2337/dc07-1338
   Franceschi C, 2007, MECH AGEING DEV, V128, P92, DOI 10.1016/j.mad.2006.11.016
   Fung TT, 2005, AM J CLIN NUTR, V82, P163
   Grunnet LG, 2009, DIABETES, V58, P1807, DOI 10.2337/db08-0178
   Hamdy O, 2006, CURR DIABETES REV, V2, P367, DOI 10.2174/1573399810602040367
   Haubner F, 2007, BIOCHEM BIOPH RES CO, V360, P560, DOI 10.1016/j.bbrc.2007.06.044
   Haus JM, 2009, DIABETES, V58, P337, DOI 10.2337/db08-1228
   Herder C, 2009, DIABETOLOGIA, V52, P433, DOI 10.1007/s00125-008-1243-1
   Holick MF, 2008, CURR DIABETES REP, V8, P393, DOI 10.1007/s11892-008-0068-0
   Hotamisligil GS, 2008, NAT REV IMMUNOL, V8, P923, DOI 10.1038/nri2449
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Huey KA, 2008, J NEUROIMMUNOL, V199, P56, DOI 10.1016/j.jneuroim.2008.05.004
   Hundal RS, 2002, J CLIN INVEST, V109, P1321, DOI 10.1172/JCI200214955
   Irwin MR, 2008, BIOL PSYCHIAT, V64, P538, DOI 10.1016/j.biopsych.2008.05.004
   Kahn SE, 2009, DIABETOLOGIA, V52, P1003, DOI 10.1007/s00125-009-1321-z
   Kempf K, 2007, J MOL MED, V85, P389, DOI 10.1007/s00109-006-0132-7
   Kim EK, 2007, INT J BIOCHEM CELL B, V39, P1260, DOI 10.1016/j.biocel.2007.04.005
   Kim HJ, 2004, DIABETES, V53, P1060, DOI 10.2337/diabetes.53.4.1060
   Kintscher U, 2008, ARTERIOSCL THROM VAS, V28, P1304, DOI 10.1161/ATVBAHA.108.165100
   Knol MJ, 2006, DIABETOLOGIA, V49, P837, DOI 10.1007/s00125-006-0159-x
   Kolb H, 2005, DIABETOLOGIA, V48, P1038, DOI 10.1007/s00125-005-1764-9
   Koska J, 2009, DIABETOLOGIA, V52, P385, DOI 10.1007/s00125-008-1239-x
   Laine PS, 2007, BIOCHEM BIOPH RES CO, V358, P150, DOI 10.1016/j.bbrc.2007.04.092
   Lambertucci RH, 2008, J CELL PHYSIOL, V216, P796, DOI 10.1002/jcp.21463
   Larsen CM, 2007, NEW ENGL J MED, V356, P1517, DOI 10.1056/NEJMoa065213
   Larsen CM, 2009, DIABETES CARE, V32, P1663, DOI 10.2337/dc09-0533
   Li L, 2009, CYTOKINE, V45, P12, DOI 10.1016/j.cyto.2008.10.006
   Lumeng CN, 2007, AM J PHYSIOL-ENDOC M, V292, pE166, DOI 10.1152/ajpendo.00284.2006
   Lupi R, 2004, AM J PHYSIOL-ENDOC M, V286, pE560, DOI 10.1152/ajpendo.00561.2002
   Maedler K, 2002, J CLIN INVEST, V110, P851, DOI 10.1172/JCI200215318
   Maedler K, 2004, P NATL ACAD SCI USA, V101, P8138, DOI 10.1073/pnas.0305683101
   Maedler K, 2001, DIABETES, V50, P69, DOI 10.2337/diabetes.50.1.69
   Manco M, 2007, J CLIN ENDOCR METAB, V92, P483, DOI 10.1210/jc.2006-0960
   Manning PJ, 2004, DIABETES CARE, V27, P2509, DOI 10.2337/diacare.27.10.2509
   Maraldi C, 2007, ARCH INTERN MED, V167, P1137, DOI 10.1001/archinte.167.11.1137
   Mathur N, 2008, MEDIAT INFLAMM, V2008, DOI 10.1155/2008/109502
   McAfoose J, 2009, NEUROSCI BIOBEHAV R, V33, P355, DOI 10.1016/j.neubiorev.2008.10.005
   Meier-Ewert HK, 2004, J AM COLL CARDIOL, V43, P678, DOI 10.1016/j.jacc.2003.07.050
   Milanski M, 2009, J NEUROSCI, V29, P359, DOI 10.1523/JNEUROSCI.2760-08.2009
   Mohanty P, 2000, J CLIN ENDOCR METAB, V85, P2970, DOI 10.1210/jc.85.8.2970
   Müller S, 2002, DIABETOLOGIA, V45, P805, DOI 10.1007/s00125-002-0829-2
   Nappo F, 2002, J AM COLL CARDIOL, V39, P1145, DOI 10.1016/S0735-1097(02)01741-2
   North CJ, 2009, EUR J CLIN NUTR, V63, P921, DOI 10.1038/ejcn.2009.8
   Ohashi K, 2000, J IMMUNOL, V164, P558, DOI 10.4049/jimmunol.164.2.558
   Okada T, 2007, P NATL ACAD SCI USA, V104, P8977, DOI 10.1073/pnas.0608703104
   Pachco YA, 2008, J NUTR BIOCHEM, V19, P200, DOI 10.1016/j.jnutbio.2007.03.002
   PALMER JP, 1989, DIABETES, V38, P1211, DOI 10.2337/diabetes.38.10.1211
   Patel C, 2007, J CLIN ENDOCR METAB, V92, P4476, DOI 10.1210/jc.2007-0778
   Peterson JM, 2009, J APPL PHYSIOL, V106, P130, DOI 10.1152/japplphysiol.90584.2008
   Pfleger C, 2008, DIABETES, V57, P929, DOI 10.2337/db07-1697
   Piconi L, 2004, J THROMB HAEMOST, V2, P1453, DOI 10.1111/j.1538-7836.2004.00835.x
   Poggi M, 2007, DIABETOLOGIA, V50, P1267, DOI 10.1007/s00125-007-0654-8
   Poppitt SD, 2008, NUTRITION, V24, P322, DOI 10.1016/j.nut.2007.12.012
   Puglisi MJ, 2008, J NUTR, V138, P2293, DOI 10.3945/jn.108.097188
   Pulkki-Råback L, 2009, HEALTH PSYCHOL, V28, P108, DOI 10.1037/a0012646
   Raison CL, 2009, BIOL PSYCHIAT, V65, P296, DOI 10.1016/j.biopsych.2008.08.010
   Schaeffler A, 2009, IMMUNOLOGY, V126, P233, DOI 10.1111/j.1365-2567.2008.02892.x
   Schenk S, 2008, J CLIN INVEST, V118, P2992, DOI 10.1172/JCI34260
   Schmitz G, 2008, PROG LIPID RES, V47, P147, DOI 10.1016/j.plipres.2007.12.004
   Shi H, 2006, J CLIN INVEST, V116, P3015, DOI 10.1172/JCI28898
   Silva LA, 2008, INT J SPORT NUTR EXE, V18, P379, DOI 10.1123/ijsnem.18.4.379
   Strissel KJ, 2007, DIABETES, V56, P2910, DOI 10.2337/db07-0767
   Su SY, 2009, PSYCHOSOM MED, V71, P152, DOI 10.1097/PSY.0b013e31819082ef
   Tasali E, 2009, PROG CARDIOVASC DIS, V51, P381, DOI 10.1016/j.pcad.2008.10.002
   Tousoulis D, 2009, INT J CARDIOL, V134, P238, DOI 10.1016/j.ijcard.2008.02.013
   Tripathy D, 2003, DIABETES, V52, P2882, DOI 10.2337/diabetes.52.12.2882
   Uribarri J, 2005, ANN NY ACAD SCI, V1043, P461, DOI 10.1196/annals.1333.052
   Velloso LA, 2008, NEUROIMMUNOMODULAT, V15, P189, DOI 10.1159/000153423
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yu HY, 2001, DIABETOLOGIA, V44, P614, DOI 10.1007/s001250051668
   Yuen DYC, 2009, DIABETES, V58, P1086, DOI 10.2337/db08-0775
NR 100
TC 227
Z9 262
U1 0
U2 31
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
J9 DIABETOLOGIA
JI Diabetologia
PD JAN
PY 2010
VL 53
IS 1
BP 10
EP 20
DI 10.1007/s00125-009-1573-7
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 529PV
UT WOS:000272530600003
PM 19890624
OA Bronze
DA 2025-06-11
ER

PT J
AU Shao, D
   Fry, JL
   Han, JY
   Hou, XY
   Pimentel, DR
   Matsui, R
   Cohen, RA
   Bachschmid, MM
AF Shao, Di
   Fry, Jessica L.
   Han, Jingyan
   Hou, Xiuyun
   Pimentel, David R.
   Matsui, Reiko
   Cohen, Richard A.
   Bachschmid, Markus M.
TI A Redox-resistant Sirtuin-1 Mutant Protects against Hepatic Metabolic
   and Oxidant Stress
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
DE Glutathionylation; Metabolic Diseases; Oxidative Stress; Polyphenols;
   Resveratrol; Glutathiolation; High Fat High Sucrose Diet; Reactive
   Oxygen and Nitrogen Species
ID HIGH-FAT DIET; NF-KAPPA-B; REGULATES SIRT1; CELL-SURVIVAL; HEPATOCYTE
   APOPTOSIS; ANTIOXIDANT STATUS; LIVER; P53; EXPRESSION; PHOSPHORYLATION
AB Background: Sirtuin-1 improves metabolic disease, but oxidants may inhibit it. Results: Metabolic stress increased glutathione adducts, inactivated endogenous Sirtuin-1, and promoted apoptosis. A novel Sirtuin-1 oxidation-insensitive mutant or glutaredoxin-1 prevented metabolic dysregulation and apoptosis. Conclusion: A novel Sirtuin-1 mutant circumvents oxidation and more effectively inhibits metabolic dysregulation and apoptosis. Significance: Oxidative inactivation of Sirtuin-1 contributes to metabolic disease.
   Sirtuin-1 (SirT1), a member of the NAD(+)-dependent class III histone deacetylase family, is inactivated in vitro by oxidation of critical cysteine thiols. In a model of metabolic syndrome, SirT1 activation attenuated apoptosis of hepatocytes and improved liver function including lipid metabolism. We show in SirT1-overexpressing HepG2 cells that oxidants (nitrosocysteine and hydrogen peroxide) or metabolic stress (high palmitate and high glucose) inactivated SirT1 by reversible oxidative post-translational modifications (OPTMs) on three cysteines. Mutating these oxidation-sensitive cysteines to serine preserved SirT1 activity and abolished reversible OPTMs. Overexpressed mutant SirT1 maintained deacetylase activity and attenuated proapoptotic signaling, whereas overexpressed wild type SirT1 was less protective in metabolically or oxidant-stressed cells. To prove that OPTMs of SirT1 are glutathione (GSH) adducts, glutaredoxin-1 was overexpressed to remove this modification. Glutaredoxin-1 overexpression maintained endogenous SirT1 activity and prevented proapoptotic signaling in metabolically stressed HepG2 cells. The in vivo significance of oxidative inactivation of SirT1 was investigated in livers of high fat diet-fed C57/B6J mice. SirT1 deacetylase activity was decreased in the absence of changes in SirT1 expression and associated with a marked increase in OPTMs. These results indicate that glutathione adducts on specific SirT1 thiols may be responsible for dysfunctional SirT1 associated with liver disease in metabolic syndrome.
C1 [Shao, Di; Fry, Jessica L.; Han, Jingyan; Hou, Xiuyun; Matsui, Reiko; Cohen, Richard A.; Bachschmid, Markus M.] Boston Univ, Sch Med, Vasc Biol Sect, Boston, MA 02118 USA.
   [Pimentel, David R.] Boston Univ, Sch Med, Whitaker Cardiovasc Inst, Myocardial Biol Unit, Boston, MA 02118 USA.
   [Cohen, Richard A.; Bachschmid, Markus M.] Boston Univ, Sch Med, Cardiovasc Proteom Ctr, Boston, MA 02118 USA.
C3 Boston University; Boston University; Boston University
RP Bachschmid, MM (corresponding author), Boston Univ, Sch Med, Whitaker Cardiovasc Inst, Vasc Biol Sect, Boston, MA 02118 USA.
EM bach@bu.edu
RI Shao, Di/F-9758-2016; han, jingyan/HJG-6568-2022
OI Fry, Jessica/0000-0003-2748-0334; /0000-0002-1070-6408; Bachschmid,
   Markus Michael/0000-0002-0748-5528
FU National Institutes of Health [PO1 HL 068758, R37 HL104017]; NHLBI,
   National Institutes of Health, Department of Health and Human Services
   [HHSN268201000031C]; National Institutes of Health Cardiovascular
   Post-doctoral Training Grant [HL007224]
FX This work was supported, in whole or in part, by National Institutes of
   Health Grants PO1 HL 068758 and R37 HL104017 and the NHLBI, National
   Institutes of Health, Department of Health and Human Services under
   Contract HHSN268201000031C.Supported by National Institutes of Health
   Cardiovascular Post-doctoral Training Grant HL007224.
CR Abdelmohsen K, 2007, MOL CELL, V25, P543, DOI 10.1016/j.molcel.2007.01.011
   Ahmadian M, 2013, NAT MED, V19, P557, DOI 10.1038/nm.3159
   Ahn BH, 2008, P NATL ACAD SCI USA, V105, P14447, DOI 10.1073/pnas.0803790105
   Caito S, 2010, FASEB J, V24, P3145, DOI 10.1096/fj.09-151308
   Cao J, 2012, MOL CELL BIOCHEM, V364, P115, DOI 10.1007/s11010-011-1211-9
   Caton PW, 2013, DIABETOLOGIA, V56, P1068, DOI 10.1007/s00125-013-2851-y
   Chen WY, 2005, CELL, V123, P437, DOI 10.1016/j.cell.2005.08.011
   Cheng HL, 2003, P NATL ACAD SCI USA, V100, P10794, DOI 10.1073/pnas.1934713100
   Costantini S, 2013, BMC EVOL BIOL, V13, DOI 10.1186/1471-2148-13-60
   Deng XQ, 2007, LIVER INT, V27, P708, DOI 10.1111/j.1478-3231.2007.01497.x
   Elliott PJ, 2008, CURR OPIN INVEST DR, V9, P371
   Escande C, 2010, J CLIN INVEST, V120, P545, DOI 10.1172/JCI39319
   Feldstein AE, 2003, GASTROENTEROLOGY, V125, P437, DOI 10.1016/S0016-5085(03)00907-7
   Fulco M, 2003, MOL CELL, V12, P51, DOI 10.1016/S1097-2765(03)00226-0
   Furukawa A, 2007, CELL PHYSIOL BIOCHEM, V20, P45, DOI 10.1159/000104152
   Gao ZG, 2011, J BIOL CHEM, V286, P22227, DOI 10.1074/jbc.M111.228874
   Gerhart-Hines Z, 2011, MOL CELL, V44, P851, DOI 10.1016/j.molcel.2011.12.005
   Guo XM, 2010, J BIOL CHEM, V285, P13223, DOI 10.1074/jbc.M110.102574
   Haeussler DJ, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023160
   Haigis MC, 2006, CELL, V126, P941, DOI 10.1016/j.cell.2006.06.057
   Haigis MC, 2010, ANNU REV PATHOL-MECH, V5, P253, DOI 10.1146/annurev.pathol.4.110807.092250
   Hou XY, 2008, J BIOL CHEM, V283, P20015, DOI 10.1074/jbc.M802187200
   Hubbard BP, 2013, SCIENCE, V339, P1216, DOI 10.1126/science.1231097
   Ishikawa S, 2013, BMC VET RES, V9, DOI 10.1186/1746-6148-9-187
   Joshi-Barve S, 2007, HEPATOLOGY, V46, P823, DOI 10.1002/hep.21752
   Jung SK, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0080115
   Kendrick AA, 2011, BIOCHEM J, V433, P505, DOI 10.1042/BJ20100791
   Kornberg MD, 2010, NAT CELL BIOL, V12, P1094, DOI 10.1038/ncb2114
   Koruk M, 2004, ANN CLIN LAB SCI, V34, P57
   Kwon HS, 2008, TRENDS BIOCHEM SCI, V33, P517, DOI 10.1016/j.tibs.2008.08.001
   Langley E, 2002, EMBO J, V21, P2383, DOI 10.1093/emboj/21.10.2383
   Li S., 2010, PLoS One, V5
   Li Y, 2011, CELL METAB, V13, P376, DOI 10.1016/j.cmet.2011.03.009
   Luo JY, 2001, CELL, V107, P137, DOI 10.1016/S0092-8674(01)00524-4
   Madan K, 2006, J CLIN GASTROENTEROL, V40, P930, DOI 10.1097/01.mcg.0000212608.59090.08
   Mieyal JJ, 2008, ANTIOXID REDOX SIGN, V10, P1941, DOI 10.1089/ars.2008.2089
   Mostoslavsky R, 2006, CELL, V124, P315, DOI 10.1016/J.CEL.2005.11.044
   Nasrin N, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0008414
   Nemoto S, 2005, J BIOL CHEM, V280, P16456, DOI 10.1074/jbc.M501485200
   Nin V, 2012, J BIOL CHEM, V287, P23489, DOI 10.1074/jbc.M112.365874
   Nogueiras R, 2012, PHYSIOL REV, V92, P1479, DOI 10.1152/physrev.00022.2011
   North BJ, 2003, MOL CELL, V11, P437, DOI 10.1016/S1097-2765(03)00038-8
   Olmos Y, 2013, ANTIOXID REDOX SIGN, V19, P1507, DOI 10.1089/ars.2012.4713
   Park SJ, 2012, CELL, V148, P421, DOI 10.1016/j.cell.2012.01.017
   Peck B, 2010, MOL CANCER THER, V9, P844, DOI 10.1158/1535-7163.MCT-09-0971
   Pfluger PT, 2008, P NATL ACAD SCI USA, V105, P9793, DOI 10.1073/pnas.0802917105
   Potente M, 2008, CELL CYCLE, V7, P2117, DOI 10.4161/cc.7.14.6267
   Prozorovski T, 2008, NAT CELL BIOL, V10, P385, DOI 10.1038/ncb1700
   Purushotham A, 2009, CELL METAB, V9, P327, DOI 10.1016/j.cmet.2009.02.006
   Qin FZ, 2012, CIRCULATION, V125, P1757, DOI 10.1161/CIRCULATIONAHA.111.067801
   Ribeiro PS, 2004, AM J GASTROENTEROL, V99, P1708, DOI 10.1111/j.1572-0241.2004.40009.x
   Roy A, 2010, NAT PROTOC, V5, P725, DOI 10.1038/nprot.2010.5
   Ruifrok AC, 2001, ANAL QUANT CYTOL, V23, P291
   Ruiz-Ramírez A, 2011, AM J PHYSIOL-ENDOC M, V301, pE1198, DOI 10.1152/ajpendo.00631.2010
   Sasaki T, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0004020
   Shin JY, 2013, CELL REP, V5, P654, DOI 10.1016/j.celrep.2013.10.007
   Strum JC, 2009, MOL ENDOCRINOL, V23, P1876, DOI 10.1210/me.2009-0117
   Tanno M, 2007, J BIOL CHEM, V282, P6823, DOI 10.1074/jbc.M609554200
   Vaziri H, 2001, CELL, V107, P149, DOI 10.1016/S0092-8674(01)00527-X
   Ward JJ, 2004, J MOL BIOL, V337, P635, DOI 10.1016/j.jmb.2004.02.002
   Westphal CH, 2007, TRENDS BIOCHEM SCI, V32, P555, DOI 10.1016/j.tibs.2007.09.008
   Xu SQ, 2011, J CARDIOVASC PHARM, V58, P263, DOI 10.1097/FJC.0b013e3182239eb7
   Yamazaki Y, 2009, AM J PHYSIOL-ENDOC M, V297, pE1179, DOI 10.1152/ajpendo.90997.2008
   Yang YH, 2007, NAT CELL BIOL, V9, P1253, DOI 10.1038/ncb1645
   Yeung F, 2004, EMBO J, V23, P2369, DOI 10.1038/sj.emboj.7600244
   You M, 2008, J NUTR, V138, P497, DOI 10.1093/jn/138.3.497
   Yu J, 2003, P NATL ACAD SCI USA, V100, P1931, DOI 10.1073/pnas.2627984100
   Yu JJ, 2013, SCI REP-UK, V3, DOI 10.1038/srep02806
   Zang MW, 2004, J BIOL CHEM, V279, P47898, DOI 10.1074/jbc.M408149200
   Zee RS, 2010, ANTIOXID REDOX SIGN, V13, P1023, DOI 10.1089/ars.2010.3251
   Zhang YH, 2004, P NATL ACAD SCI USA, V101, P7891, DOI 10.1073/pnas.0401167101
   Zschoernig B, 2009, BIOCHEM BIOPH RES CO, V381, P372, DOI 10.1016/j.bbrc.2009.02.085
NR 72
TC 60
Z9 62
U1 0
U2 14
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 14
PY 2014
VL 289
IS 11
BP 7293
EP 7306
DI 10.1074/jbc.M113.520403
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA AC8CV
UT WOS:000332761500004
PM 24451382
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Yokota, T
   Kinugawa, S
   Yamato, M
   Hirabayashi, K
   Suga, T
   Takada, S
   Harada, K
   Morita, N
   Oyama-Manabe, N
   Kikuchi, Y
   Okita, K
   Tsutsui, H
AF Yokota, Takashi
   Kinugawa, Shintaro
   Yamato, Mayumi
   Hirabayashi, Kagami
   Suga, Tadashi
   Takada, Shingo
   Harada, Kuniaki
   Morita, Noriteru
   Oyama-Manabe, Noriko
   Kikuchi, Yasuka
   Okita, Koichi
   Tsutsui, Hiroyuki
TI Systemic Oxidative Stress Is Associated With Lower Aerobic Capacity and
   Impaired Skeletal Muscle Energy Metabolism in Patients With Metabolic
   Syndrome
SO DIABETES CARE
LA English
DT Article
ID LOW CARDIORESPIRATORY FITNESS; INSULIN-RESISTANCE; MITOCHONDRIAL
   DYSFUNCTION; DIABETES-MELLITUS; WEIGHT-LOSS; MORTALITY; OBESITY;
   INDIVIDUALS; RESPIRATION; EXERCISE
AB OBJECTIVE-Systemic oxidative stress is associated with insulin resistance and obesity. We tested the hypothesis that systemic oxidative stress is linked to lower aerobic capacity and skeletal muscle dysfunction in metabolic syndrome (MetS).
   RESEARCH DESIGN AND METHODS-The incremental exercise testing with cycle ergometer was performed in 14 male patients with MetS and 13 age-, sex-, and activity-matched healthy subjects. Systemic lipid peroxidation was assessed by serum thiobarbituric acid reactive substances (TBARS), and systemic antioxidant defense capacity was assessed by serum total thiols and enzymatic activity of superoxide dismutase (SOD). To assess skeletal muscle energy metabolism, we measured high-energy phosphates in the calf muscle during plantar flexion exercise and intramyocellular lipid (IMCL) in the resting leg muscle, using P-31- and (1)proton-magnetic resonance spectroscopy, respectively.
   RESULTS-Serum TBARS were elevated (12.4 +/- 7.1 vs. 3.7 +/- 1.1 mu mol/L; P < 0.01), and serum total thiols and SOD activity were decreased (290.8 +/- 51.2 vs. 398.7 +/- 105.2 mu mol/L, P < 0.01; and 22.2 +/- 8.4 vs. 31.5 +/- 8.5 units/L, P < 0.05, respectively) in patients with MetS compared with healthy subjects. Peak VO2 and anaerobic threshold normalized to body weight were significantly lower in MetS patients by 25 and 31%, respectively, and inversely correlated with serum TBARS (r = -0.49 and r = -0.50, respectively). Moreover, muscle phosphocreatine loss during exercise was 1.4-fold greater in patients with MetS (P < 0.05), and IMCL content was 2.9-fold higher in patients with MetS (P < 0.01), indicating impaired skeletal muscle energy metabolism, and these indices positively correlated with serum TBARS (r = 0.45 and r = 0.63, respectively).
   CONCLUSIONS-Systemic oxidative stress was associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in patients with MetS.
C1 [Yokota, Takashi; Kinugawa, Shintaro; Hirabayashi, Kagami; Suga, Tadashi; Takada, Shingo; Tsutsui, Hiroyuki] Hokkaido Univ Grad Sch Med, Dept Cardiovasc Med, Sapporo, Hokkaido, Japan.
   [Yokota, Takashi] Univ Copenhagen, Ctr Hlth Aging, Dept Biomed Sci, Copenhagen, Denmark.
   [Yamato, Mayumi] Kyushu Univ, Innovat Ctr Med Redox Nav, Fukuoka 812, Japan.
   [Suga, Tadashi; Takada, Shingo] Japan Soc Promot Sci, Tokyo, Japan.
   [Harada, Kuniaki] Sapporo Med Univ, Div Radiol, Sapporo, Hokkaido, Japan.
   [Morita, Noriteru] Hokkaido Univ, Dept Sports Educ, Iwamizawa, Japan.
   [Oyama-Manabe, Noriko; Kikuchi, Yasuka] Hokkaido Univ Hosp, Dept Diagnost & Intervent Radiol, Sapporo, Hokkaido 060, Japan.
   [Okita, Koichi] Hokusho Univ, Grad Sch Program Lifelong Learning Studies, Ebetsu, Hokkaido, Japan.
C3 Hokkaido University; University of Copenhagen; Kyushu University; Japan
   Society for the Promotion of Science; Sapporo Medical University;
   Hokkaido University; Hokkaido University
RP Kinugawa, S (corresponding author), Hokkaido Univ Grad Sch Med, Dept Cardiovasc Med, Sapporo, Hokkaido, Japan.
EM tuckahoe@med.hokudai.ac.jp
RI Kinugawa, Shintaro/E-1268-2012; Morita, Noriteru/U-1189-2019; 真鍋,
   徳子/JZD-4246-2024
OI Morita, Noriteru/0000-0003-3427-7174
FU Ministry of Education, Culture, Sports, Science, and Technology of Japan
   [18790487, 17390223, 20117004, 21390236]; Meiji Yasuda Life Foundation
   of Health and Welfare; Mitsui Life Social Welfare Foundation; Uehara
   Memorial Foundation; Grants-in-Aid for Scientific Research [18790487,
   21390236, 25882041, 17390223, 23500784, 20117004] Funding Source: KAKEN
FX This study was supported by grants from the Ministry of Education,
   Culture, Sports, Science, and Technology of Japan (18790487, 17390223,
   20117004, and 21390236), Meiji Yasuda Life Foundation of Health and
   Welfare, Mitsui Life Social Welfare Foundation, and the Uehara Memorial
   Foundation.
CR ANDO Y, 1973, BIOCHIM BIOPHYS ACTA, V311, P26, DOI 10.1016/0005-2736(73)90251-4
   BEAVER WL, 1986, J APPL PHYSIOL, V60, P2020, DOI 10.1152/jappl.1986.60.6.2020
   Befroy DE, 2007, DIABETES, V56, P1376, DOI 10.2337/db06-0783
   Bonnard C, 2008, J CLIN INVEST, V118, P789, DOI 10.1172/JCI32601
   Dalle-Donne I, 2006, CLIN CHEM, V52, P601, DOI 10.1373/clinchem.2005.061408
   Carneiro JLD, 2009, J CANCER RES CLIN, V135, P997, DOI 10.1007/s00432-008-0535-7
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   Gao CL, 2010, MOL CELL ENDOCRINOL, V320, P25, DOI 10.1016/j.mce.2010.01.039
   GOPAUL NK, 1995, FEBS LETT, V368, P225, DOI 10.1016/0014-5793(95)00649-T
   Inoue T, 2009, FREE RADICAL RES, V43, P37, DOI 10.1080/10715760802534820
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Kelley DE, 1999, AM J PHYSIOL-ENDOC M, V277, pE1130
   Kemp M, 2008, FREE RADICAL BIO MED, V44, P921, DOI 10.1016/j.freeradbiomed.2007.11.008
   Kikuchi A, 2002, NEUROBIOL DIS, V9, P244, DOI 10.1006/nbdi.2002.0466
   Kim JA, 2008, CIRC RES, V102, P401, DOI 10.1161/CIRCRESAHA.107.165472
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Meigs JB, 2007, DIABETES CARE, V30, P2529, DOI 10.2337/dc07-0817
   Mogensen M, 2007, DIABETES, V56, P1592, DOI 10.2337/db06-0981
   Morgan PE, 2009, FREE RADICAL RES, V43, P117, DOI 10.1080/10715760802623896
   Moro C, 2009, J CLIN ENDOCR METAB, V94, P3440, DOI 10.1210/jc.2009-0053
   Paolisso G, 1996, J CLIN ENDOCR METAB, V81, P4244, DOI 10.1210/jc.81.12.4244
   Perseghin G, 2005, CURR OPIN LIPIDOL, V16, P416, DOI 10.1097/01.mol.0000174401.07056.56
   Petersen KF, 2004, NEW ENGL J MED, V350, P664, DOI 10.1056/NEJMoa031314
   Rains JL, 2011, FREE RADICAL BIO MED, V50, P567, DOI 10.1016/j.freeradbiomed.2010.12.006
   Rector RS, 2007, AM J PHYSIOL-ENDOC M, V293, pE500, DOI 10.1152/ajpendo.00116.2007
   Russell AP, 2003, FEBS LETT, V551, P104, DOI 10.1016/S0014-5793(03)00875-5
   Schrauwen P, 2004, DIABETES, V53, P1412, DOI 10.2337/diabetes.53.6.1412
   Slatter DA, 2000, DIABETOLOGIA, V43, P550, DOI 10.1007/s001250051342
   Van Guilder GP, 2006, OBESITY, V14, P2127, DOI 10.1038/oby.2006.248
   Wei M, 2000, ANN INTERN MED, V132, P605, DOI 10.7326/0003-4819-132-8-200004180-00002
   Wei M, 1999, JAMA-J AM MED ASSOC, V282, P1547, DOI 10.1001/jama.282.16.1547
   Wei YZ, 2006, J BIOL CHEM, V281, P35137, DOI 10.1074/jbc.M601320200
   Yang M, 2006, AM J HYPERTENS, V19, P587, DOI 10.1016/j.amjhyper.2005.11.017
   Yokota T, 2011, HYPERTENS RES, V34, P1029, DOI 10.1038/hr.2011.78
   Yokota T, 2009, AM J PHYSIOL-HEART C, V297, pH1069, DOI 10.1152/ajpheart.00267.2009
NR 35
TC 50
Z9 54
U1 0
U2 12
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD MAY
PY 2013
VL 36
IS 5
BP 1341
EP 1346
DI 10.2337/dc12-1161
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 155WW
UT WOS:000319782100044
PM 23393211
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Chan, MY
   Lee, BJ
   Chang, PS
   Hsiao, HY
   Hsu, LP
   Chang, CH
   Lin, PT
AF Chan, Man-Yee
   Lee, Bor-Jen
   Chang, Po-Sheng
   Hsiao, Han-Yu
   Hsu, Li-Ping
   Chang, Chia-Hua
   Lin, Ping-Ting
TI The risks of ubiquinone and β-carotene deficiency and metabolic
   disorders in patients with oral cancer
SO BMC CANCER
LA English
DT Article
DE Ubiquinone; beta-Carotene; Antioxidant vitamins; Metabolic disorders;
   Oral cancer
ID ANTIOXIDANT STATUS; OXIDATIVE STRESS; ALPHA-TOCOPHEROL; SUBSEQUENT RISK;
   SERUM; BLOOD; INFLAMMATION; PRECANCER; CAPACITY; VITAMINS
AB BackgroundCancer development is mediated by oxidative stress and inflammation, which may correlate with metabolic disorders. The aim of this study was to evaluate antioxidant vitamins status and metabolic parameters in patients with oral cancer according to tumor-node-metastasis (TNM) stages.MethodsA total of 194 patients with oral cancer were enrolled in this study. The patients were stratified for four groups according to cancer stages and that the statistics are comparisons across these groups. The levels of antioxidant vitamins (ubiquinone, beta -carotene, vitamin A and E), metabolic parameters, oxidative stress, antioxidant enzymes activity, and inflammatory markers were measured.ResultsMore than half of the subjects had high blood pressure, central obesity, hyperglycemia, and hyperlipidemia regardless of TNM stage. With regard to antioxidant vitamins status, 46 and 94% of patients had beta -carotene and ubiquinone deficiency, respectively. Patients in T3 and T4 stages had significantly lower antioxidant enzyme (catalase, p=0.03) activity and higher inflammatory markers levels (high sensitivity C-reactive protein and interleukin-6, p<0.01) than patients in the other stages. In addition, the level of -carotene was negatively associated with waist circumference, and ubiquinone was positively associated with the level of high-density lipoprotein cholesterol (p<0.05). Higher -carotene and ubiquinone levels were negatively associated with hypertriglyceridemia and the risk of metabolic syndrome (p<0.05).ConclusionsA high proportion of patients with oral cancer had ubiquinone or -carotene deficiency and metabolic disorders. The level of ubiquinone or beta -carotene was negatively associated with the risk of central obesity, hypertriglyceridemia, and metabolic syndrome. Since patients with oral cancer suffer from high oxidative stress and inflammation (particularly in the T3 and T4 stages), supplementation with antioxidant vitamins such as ubiquinone or beta -carotene could be preferentially applied.
C1 [Chan, Man-Yee; Hsiao, Han-Yu] Taichung Vet Gen Hosp, Div Oral & Maxillofacial Surg, Dept Stomatol, Taichung 407204, Taiwan.
   [Chan, Man-Yee] Chung Shan Med Univ, Sch Dent, Coll Oral Med, Taichung 402367, Taiwan.
   [Lee, Bor-Jen] Tungs Taichung Metro Harbor Hosp, Dept Internal Med, Taichung 433402, Taiwan.
   [Lee, Bor-Jen] Chung Shan Med Univ, Sch Med, Taichung 402367, Taiwan.
   [Chang, Po-Sheng; Hsu, Li-Ping; Chang, Chia-Hua; Lin, Ping-Ting] Chung Shan Med Univ, Dept Nutr, Taichung 402367, Taiwan.
   [Chang, Po-Sheng] Chung Shan Med Univ, Grad Program Nutr, Taichung 402367, Taiwan.
   [Lin, Ping-Ting] Chung Shan Med Univ Hosp, Dept Nutr, Taichung 402367, Taiwan.
C3 Taichung Veterans General Hospital; Chung Shan Medical University; Chung
   Shan Medical University; Chung Shan Medical University; Chung Shan
   Medical University; Chung Shan Medical University; Chung Shan Medical
   University Hospital
RP Lin, PT (corresponding author), Chung Shan Med Univ, Dept Nutr, Taichung 402367, Taiwan.; Lin, PT (corresponding author), Chung Shan Med Univ Hosp, Dept Nutr, Taichung 402367, Taiwan.
EM apt810@csmu.edu.tw
FU Ministry of Health and Welfare, Taiwan [MOHW103-TD-B-111-10,
   MOHW104-TDU-B-211-124004, MOHW105-TDU-B-211-134002,
   MOHW106-TDU-B-211-144002]; Taichung Veterans General Hospital
   [TCVGH-1085606C]
FX This study was supported by a grant from the Ministry of Health and
   Welfare, Taiwan (MOHW103-TD-B-111-10, MOHW104-TDU-B-211-124004,
   MOHW105-TDU-B-211-134002 and MOHW106-TDU-B-211-144002), and the Taichung
   Veterans General Hospital (TCVGH-1085606C). The funders had no role in
   the design of the study, collection, analysis, and interpretation of
   data or in writing the manuscript.
CR AEBI H, 1984, METHOD ENZYMOL, V105, P121
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Athirajan V, 2014, ASIAN PAC J CANCER P, V15, P8183, DOI 10.7314/APJCP.2014.15.19.8183
   Beydoun MA, 2011, J NUTR, V141, P903, DOI 10.3945/jn.110.136580
   Chang CC, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2015-008788
   Chen SS, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0050456, 10.1371/journal.pone.0049275, 10.1371/journal.pone.0045763, 10.1371/journal.pone.0036784]
   Chippagiri P, 2014, J CLIN DIAGN RES, V8, pZC1, DOI 10.7860/JCDR/2014/7534.4211
   Choudhari SK, 2014, ORAL ONCOL, V50, P10, DOI 10.1016/j.oraloncology.2013.09.011
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Crane FL, 2001, J AM COLL NUTR, V20, P591, DOI 10.1080/07315724.2001.10719063
   Folkers K, 1997, BIOCHEM BIOPH RES CO, V234, P296, DOI 10.1006/bbrc.1997.6522
   GAREWAL HS, 1995, ARCH OTOLARYNGOL, V121, P141
   Godala M, 2017, ADV CLIN EXP MED, V26, P581, DOI 10.17219/acem/62453
   Godala MM, 2016, ADV CLIN EXP MED, V25, P689, DOI 10.17219/acem/41049
   Gokul S, 2010, ORAL DIS, V16, P29, DOI 10.1111/j.1601-0825.2009.01598.x
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Han Y, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/825065
   Hsu CC, 2016, EXP BIOL MED, V241, P1281, DOI 10.1177/1535370216641787
   Kand'ár R, 2013, J CHEM-NY, V2013, DOI 10.1155/2013/460242
   Karpinska J, 2006, J PHARMACEUT BIOMED, V42, P232, DOI 10.1016/j.jpba.2006.03.037
   Katakwar P, 2016, J CANCER RES THER, V12, P438, DOI 10.4103/0973-1482.151935
   Korde SD, 2011, ONCOLOGY-BASEL, V80, P382, DOI 10.1159/000329811
   Ksiezakowska-Lakoma K, 2014, MENOPAUSE REV, V13, P136, DOI 10.5114/pm.2014.42717
   Kundu JK, 2012, FREE RADICAL BIO MED, V52, P2013, DOI 10.1016/j.freeradbiomed.2012.02.035
   Lass A, 1998, ARCH BIOCHEM BIOPHYS, V352, P229, DOI 10.1006/abbi.1997.0606
   Lawal AO, 2012, NIGER J CLIN PRACT, V15, P30, DOI 10.4103/1119-3077.94093
   Lee BJ, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/9303094
   Li YR, 2013, ASIA PAC J CLIN NUTR, V22, P60, DOI 10.6133/apjcn.2013.22.1.06
   Littarru G.P., 2007, U.S. Patent, Patent No. 7303921
   Liu HT, 2017, NUTRIENTS, V9, DOI 10.3390/nu9010029
   Liu HT, 2016, NUTR J, V15, DOI 10.1186/s12937-016-0205-6
   Liu SA, 2006, HEAD NECK-J SCI SPEC, V28, P998, DOI 10.1002/hed.20461
   MARKLUND S, 1974, EUR J BIOCHEM, V47, P469
   Ministry of Health and Welfare, 2018, 2013 2016 NAT NUTR S
   Molyneux Sarah L, 2008, Clin Biochem Rev, V29, P71
   PAGLIA DE, 1967, J LAB CLIN MED, V70, P158
   Palan PR, 2003, EUR J CANCER PREV, V12, P321, DOI 10.1097/00008469-200308000-00013
   Reuter S, 2010, FREE RADICAL BIO MED, V49, P1603, DOI 10.1016/j.freeradbiomed.2010.09.006
   STOYANOVSKY DA, 1995, ARCH BIOCHEM BIOPHYS, V323, P343, DOI 10.1006/abbi.1995.9955
   TATUM VL, 1990, LIPIDS, V25, P226, DOI 10.1007/BF02535752
   WALD NJ, 1988, BRIT J CANCER, V57, P428, DOI 10.1038/bjc.1988.97
   Yen CH, 2018, BRIT J NUTR, V120, P57, DOI [10.1017/S0007114518001241, 10.1017/s0007114518001241]
   Yen CH, 2013, SCI WORLD J, DOI 10.1155/2013/767968
   Zhang ZW, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/6859523
   ZHENG W, 1993, CANCER RES, V53, P795
NR 45
TC 10
Z9 11
U1 1
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2407
J9 BMC CANCER
JI BMC Cancer
PD APR 15
PY 2020
VL 20
IS 1
DI 10.1186/s12885-020-06839-9
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA LK9OA
UT WOS:000531187700009
PM 32293339
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Román-Malo, L
   Bullon, P
AF Roman-Malo, Lourdes
   Bullon, Pedro
TI Influence of the Periodontal Disease, the Most Prevalent Inflammatory
   Event, in Peroxisome Proliferator-Activated Receptors Linking Nutrition
   and Energy Metabolism
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE periodontitis; inflammasome; mitochondria; autophagy; atherosclerosis;
   diabetes; metabolic syndrome
ID GAMMA GENE POLYMORPHISM; BONE-MINERAL DENSITY; PORPHYROMONAS-GINGIVALIS;
   OXIDATIVE STRESS; ADIPOSE-TISSUE; FREE-RADICALS; PPAR; EXPRESSION;
   OBESITY; LIPOPOLYSACCHARIDE
AB Periodontal disease is considered one of the main pathologic diseases occurring in humans. Its pathologic process involves inflammatory reactions producing periodontal bone resorption and the tooth loss. But some patients do not present an evident clinical inflammation with bone resorption, and in others, the inflammation is prominent without bone resorption. A key question could be to investigate a different way of responding to aggression. Inflammation requires a complex intracellular metabolic process, starting with the harmful recognition and activation of the inflammasome, continues the energy supply with the alteration of oxidative stress conditions, and finishes with the elimination of the aggression with autophagy/apoptosis mechanisms, then concludes with recovery. Peroxisome proliferator-activated receptors (PPARs) are essential molecules produced in inflammation, and its genes and its activation have been related to periodontal disease. Also, an important aspect is the influence of PPARs in bone metabolism; the main periodontitis symptom is bone loss and PPAR gamma activation that can downregulate the bone resorption in experimental periodontitis, PPAR gamma-coated titanium dental implant surfaces could carry the antiinflammatory gene and restrain inflammation. PPARs could be one of the meeting background points with atherosclerosis/cardiovascular disease, diabetes and metabolic syndrome showing a modified proinflammatory statement such as it is described in periodontitis.
C1 [Roman-Malo, Lourdes; Bullon, Pedro] Univ Seville, Dept Estomatol, Lab Invest, C Avicena S-N, E-41009 Seville, Spain.
C3 University of Sevilla
RP Bullon, P (corresponding author), Univ Seville, Dept Estomatol, Lab Invest, C Avicena S-N, E-41009 Seville, Spain.
EM lvrmalo@gmail.com; pbullon@us.es
RI Bullon, Pedro/E-6319-2010
OI Bullon, Pedro/0000-0003-4873-4196
CR Al Habashneh R, 2010, J PERIODONTOL, V81, P1613, DOI 10.1902/jop.2010.100190
   Andriankaja OM, 2012, J DENT RES, V91, P1160, DOI 10.1177/0022034512465292
   Andrukhov O, 2014, ACTA ODONTOL SCAND, V72, P337, DOI 10.3109/00016357.2013.834535
   Armitage GC, 2004, PERIODONTOL 2000, V34, P9, DOI 10.1046/j.0906-6713.2002.003421.x
   Armitage GC, 2003, J PERIODONTOL, V74, P1237, DOI 10.1902/jop.2003.74.8.1237
   Baltacioglu E, 2008, ARCH ORAL BIOL, V53, P716, DOI 10.1016/j.archoralbio.2008.02.002
   Battino M, 1999, CRIT REV ORAL BIOL M, V10, P458, DOI 10.1177/10454411990100040301
   Bhattarai G, 2013, CLIN ORAL IMPLAN RES, V24, P1101, DOI 10.1111/j.1600-0501.2012.02517.x
   Blanchard PG, 2012, J LIPID RES, V53, P1117, DOI 10.1194/jlr.M021485
   Brennan-Calanan RM, 2008, J DENT RES, V87, P323, DOI 10.1177/154405910808700403
   Briguglio E, 2010, PPAR RES, V2010, DOI 10.1155/2010/193019
   Bullón P, 2015, PHARMACOL RES, V91, P1, DOI 10.1016/j.phrs.2014.10.007
   Bullon P, 2014, PERIODONTOL 2000, V64, P139, DOI 10.1111/j.1600-0757.2012.00455.x
   Bullon P, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-122
   Buset SL, 2016, J CLIN PERIODONTOL, V43, P333, DOI 10.1111/jcpe.12517
   Chung JH, 2008, AGEING RES REV, V7, P126, DOI 10.1016/j.arr.2008.01.001
   Croasdell A, 2015, PPAR RES, V2015, DOI 10.1155/2015/549691
   Dagenais M, 2012, CELL DEATH DIFFER, V19, P5, DOI 10.1038/cdd.2011.159
   Dandona P, 2004, TRENDS IMMUNOL, V25, P4, DOI 10.1016/j.it.2003.10.013
   Delerive P, 1999, J BIOL CHEM, V274, P32048, DOI 10.1074/jbc.274.45.32048
   Desreumaux P, 2001, J EXP MED, V193, P827, DOI 10.1084/jem.193.7.827
   Di Paola R, 2006, J DENT RES, V85, P156, DOI 10.1177/154405910608500208
   Di Paola R, 2011, MEDIAT INFLAMM, V2011, DOI 10.1155/2011/787159
   Ding GL, 2006, J MOL CELL CARDIOL, V40, P821, DOI 10.1016/j.yjmcc.2006.03.422
   Emilsson V, 2008, NATURE, V452, P423, DOI 10.1038/nature06758
   EVANS RM, 1988, SCIENCE, V240, P889, DOI 10.1126/science.3283939
   Ferretti F, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0141834
   Folwaczny M, 2011, INNATE IMMUN-LONDON, V17, P541, DOI 10.1177/1753425910392089
   Garaulet M, 2011, MOL NUTR FOOD RES, V55, P1771, DOI 10.1002/mnfr.201100437
   Harslof T, 2011, OSTEOPOROSIS INT, V22, P2655, DOI 10.1007/s00198-010-1491-z
   Hassumi MY, 2009, INT IMMUNOPHARMACOL, V9, P1150, DOI 10.1016/j.intimp.2009.06.002
   Hirano E, 2010, J PERIODONTOL, V81, P897, DOI 10.1902/jop.2010.090669
   Iglesias J, 2017, MOL NEUROBIOL, V54, P2518, DOI 10.1007/s12035-016-9833-2
   Jenkins WMM, 2001, PERIODONTOL 2000, V26, P16, DOI 10.1034/j.1600-0757.2001.2260102.x
   Jung CH, 2010, FEBS LETT, V584, P1287, DOI 10.1016/j.febslet.2010.01.017
   Jung WK, 2009, LIFE SCI, V85, P46, DOI 10.1016/j.lfs.2009.04.010
   Kim HJ, 2013, J LEUKOCYTE BIOL, V94, P99, DOI 10.1189/jlb.1112601
   Kim K, 2016, J PERIODONTOL, V87, pE148, DOI 10.1902/jop.2016.150693
   König J, 2010, EUR J DENT EDUC, V14, P4, DOI 10.1111/j.1600-0579.2010.00620.x
   Kroemer G, 2010, MOL CELL, V40, P280, DOI 10.1016/j.molcel.2010.09.023
   Lee HJ, 2015, WORLD J GASTROENTERO, V21, P12787, DOI 10.3748/wjg.v21.i45.12787
   Lendvai A, 2016, AM J PHYSIOL-ENDOC M, V310, pE797, DOI 10.1152/ajpendo.00372.2015
   Levine B, 2008, CELL, V132, P27, DOI 10.1016/j.cell.2007.12.018
   Lin Q, 2009, FEBS J, V276, P2348, DOI 10.1111/j.1742-4658.2009.06967.x
   Lu Y, 2013, J NANOMATER, V2013, P8, DOI [10.1155/2013/984831, DOI 10.1155/2013/984831, DOI 10.1371/J0URNAL.P0NE.0070754]
   Madianos P, 2016, J CLIN PERIODONTOL, V43, P472, DOI 10.1111/jcpe.12551
   Maeda A, 2004, J CLIN LAB ANAL, V18, P317, DOI 10.1002/jcla.20045
   Mendes L, 2015, VIRULENCE, V6, P208, DOI 10.4161/21505594.2014.984566
   Michalik L, 2005, MOL ENDOCRINOL, V19, P2335, DOI 10.1210/me.2005-0068
   Michalik L, 2006, PHARMACOL REV, V58, P726, DOI 10.1124/pr.58.4.5
   Monsalve FA, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/549627
   Nareika A, 2007, J PERIODONTAL RES, V42, P31, DOI 10.1111/j.1600-0765.2006.00911.x
   Olsen I, 2016, J ORAL MICROBIOL, V8, DOI 10.3402/jom.v8.30385
   Palomer X, 2016, BBA-MOL CELL BIOL L, V1861, P1569, DOI 10.1016/j.bbalip.2016.01.019
   Pedra JHF, 2009, CURR OPIN IMMUNOL, V21, P10, DOI 10.1016/j.coi.2009.01.006
   Pepelassi E, 2012, ORAL DIS, V18, P353, DOI 10.1111/j.1601-0825.2011.01881.x
   Rinaudo P, 2012, ANNU REV PHYSIOL, V74, P107, DOI 10.1146/annurev-physiol-020911-153245
   Rühl R, 2016, MOL NUTR FOOD RES, V60, P175, DOI 10.1002/mnfr.201500619
   Salvi G E, 1998, Ann Periodontol, V3, P40, DOI 10.1902/annals.1998.3.1.40
   Santoni G, 2015, J NEUROINFLAMM, V12, DOI 10.1186/s12974-015-0239-2
   Scherz-Shouval R, 2007, TRENDS CELL BIOL, V17, P422, DOI 10.1016/j.tcb.2007.07.009
   Schroder K, 2010, CELL, V140, P821, DOI 10.1016/j.cell.2010.01.040
   Siddhivarn C, 2007, J PERIODONTAL RES, V42, P383, DOI 10.1111/j.1600-0765.2006.00965.x
   Siddhivarn C, 2006, J PERIODONTAL RES, V41, P92, DOI 10.1111/j.1600-0765.2005.00834.x
   SIES H, 1986, ANGEW CHEM INT EDIT, V25, P1058, DOI 10.1002/anie.198610581
   Stafford P, 2013, MOL ORAL MICROBIOL, V28, P366, DOI 10.1111/omi.12030
   Tain YL, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17010020
   Takanabe R, 2008, BIOCHEM BIOPH RES CO, V376, P728, DOI 10.1016/j.bbrc.2008.09.050
   Tan NS, 2001, GENE DEV, V15, P3263, DOI 10.1101/gad.207501
   Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
   Varela-Lopez A, 2016, J GERONTOL A-BIOL, V71, P593, DOI 10.1093/gerona/glv063
   Varela-López A, 2015, ANTIOXIDANTS, V4, P322, DOI 10.3390/antiox4020322
   Wan YH, 2007, NAT MED, V13, P1496, DOI 10.1038/nm1672
   Wang Y, 2013, ORAL DIS, V19, P501, DOI 10.1111/odi.12032
   Wang YM, 2016, GERODONTOLOGY, V33, P44, DOI 10.1111/ger.12110
   Wang YM, 2015, INFLAMMATION, V38, P1080, DOI 10.1007/s10753-014-0073-1
   Yessoufou A, 2010, Swiss Med Wkly, V140, pw13071, DOI 10.4414/smw.2010.13071
   Yoshihara A, 2004, J CLIN PERIODONTOL, V31, P680, DOI 10.1111/j.1600-051X.2004.00548.x
   Yoshihara A, 2015, J PERIODONTOL, V86, P955, DOI 10.1902/jop.2015.140472
   Zhou RB, 2011, NATURE, V469, P221, DOI 10.1038/nature09663
NR 80
TC 19
Z9 20
U1 3
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL
PY 2017
VL 18
IS 7
AR 1438
DI 10.3390/ijms18071438
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA FF2SJ
UT WOS:000408746800108
PM 28678155
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Hiuge-Shimizu, A
   Maeda, N
   Hirata, A
   Nakatsuji, H
   Nakamura, K
   Okuno, A
   Kihara, S
   Funahashi, T
   Shimomura, I
AF Hiuge-Shimizu, Aki
   Maeda, Norikazu
   Hirata, Ayumu
   Nakatsuji, Hideaki
   Nakamura, Kouichi
   Okuno, Akira
   Kihara, Shinji
   Funahashi, Tohru
   Shimomura, Iichiro
TI Dynamic Changes of Adiponectin and S100A8 Levels by the Selective
   Peroxisome Proliferator-Activated Receptor-γ Agonist Rivoglitazone
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE adiponectin; inflammation; oxidative stress; peroxisome
   proliferator-activated receptor; S100A8
ID METABOLIC SYNDROME; OXIDATIVE STRESS; MYOCARDIAL-INFARCTION;
   INSULIN-RESISTANCE; NUCLEAR RECEPTORS; T-CELLS; INFLAMMATION; LIGANDS;
   PROTEIN; MICE
AB Objective-Accumulating evidence indicates that the regimen to increase adiponectin will provide a novel therapeutic strategy for metabolic syndrome. Here, we tested the effect of a potent and selective peroxisome proliferator-activated receptor-gamma agonist, rivoglitazone (Rivo), a newly synthesized thiazolidinedione derivative, on adiponectin, insulin resistance, and atherosclerosis.
   Methods and Results-ob/ob mice, apolipoprotein E knockout (apoE KO) mice, and apoE and adiponectin double knockout mice were administered pioglitazone, Rivo, or no compound. Remarkable elevation of plasma adiponectin was observed, especially in Rivo-treated ob/ob mice. Rivo ameliorated insulin resistance in ob/ob mice and reduced atherosclerotic areas in apoE KO mice compared with the pioglitazone group but failed to decrease atherosclerotic areas in double knockout mice. Among adipose mRNAs, adipose S100A8, which activates Toll-like receptor 4-dependent signal transduction cascades and locates upstream of inflammation, was markedly increased in ob/ob mice, and its increase was completely reversed by Rivo treatment. In RAW264.7 macrophage cells and 3T3-L1 adipocytes, Rivo significantly reduced S100A8 mRNA levels.
   Conclusion-The peroxisome proliferator-activated receptor-gamma agonist Rivo remarkably enhanced adiponectin in plasma and decreased adipose S100A8 mRNA levels in obese mice. Rivo treatment apparently ameliorated insulin resistance in ob/ob mice and reduced atherosclerosis in apoE KO mice, partly through adiponectin. (Arterioscler Thromb Vasc Biol. 2011;31:792-799.)
C1 [Hiuge-Shimizu, Aki; Maeda, Norikazu; Hirata, Ayumu; Nakatsuji, Hideaki; Kihara, Shinji; Funahashi, Tohru; Shimomura, Iichiro] Osaka Univ, Grad Sch Med, Dept Metab Med, Suita, Osaka 5650871, Japan.
   [Nakamura, Kouichi] Daiichi Sankyo Co Ltd, Drug Metab & Pharmacokinet Res Labs, Tokyo, Japan.
   [Okuno, Akira] Daiichi Sankyo Co Ltd, R&D Planning Dept, Tokyo, Japan.
C3 The University of Osaka; Daiichi Sankyo Company Limited; Daiichi Sankyo
   Company Limited
RP Maeda, N (corresponding author), Osaka Univ, Grad Sch Med, Dept Metab Med, 2-2,B5 Yamada Oka, Suita, Osaka 5650871, Japan.
EM norikazu_maeda@endmet.med.osaka-u.ac.jp
RI Kihara, Shinji/AAW-2015-2021; Maeda, Norikazu/LZI-4561-2025
FU [19390249];  [22590979]; Grants-in-Aid for Scientific Research
   [22590978, 22590979] Funding Source: KAKEN
FX This work was supported in part by Grants-in-Aid for Scientific Research
   B 19390249 (to T.F.) and C 22590979 (to N.M.).
CR Boyd JH, 2008, CIRC RES, V102, P1239, DOI 10.1161/CIRCRESAHA.107.167544
   Croce K, 2009, CIRCULATION, V120, P427, DOI 10.1161/CIRCULATIONAHA.108.814582
   Curtis JM, 2010, DIABETES, V59, P1132, DOI 10.2337/db09-1105
   Desmots F, 1998, BIOCHEM J, V336, P437, DOI 10.1042/bj3360437
   Ehlermann P, 2006, CARDIOVASC DIABETOL, V5, DOI 10.1186/1475-2840-5-6
   Ehrchen JM, 2009, J LEUKOCYTE BIOL, V86, P557, DOI 10.1189/jlb.1008647
   Fujita K, 2008, ARTERIOSCL THROM VAS, V28, P863, DOI 10.1161/ATVBAHA.107.156687
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Glass CK, 2010, NAT REV IMMUNOL, V10, P365, DOI 10.1038/nri2748
   Grimsrud PA, 2008, J BIOL CHEM, V283, P21837, DOI 10.1074/jbc.R700019200
   Hiratsuka S, 2008, NAT CELL BIOL, V10, P1349, DOI 10.1038/ncb1794
   Hiuge A, 2007, ARTERIOSCL THROM VAS, V27, P635, DOI 10.1161/01.ATV.0000256469.06782.d5
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Huang W, 2010, ARTERIOSCL THROM VAS, V30, P1542, DOI 10.1161/ATVBAHA.109.191189
   Iwaki M, 2003, DIABETES, V52, P1655, DOI 10.2337/diabetes.52.7.1655
   Jowsey IR, 2003, BIOCHEM BIOPH RES CO, V312, P1226, DOI 10.1016/j.bbrc.2003.11.068
   Kanda S, 2009, J PHARMACOL SCI, V111, P155, DOI 10.1254/jphs.09084FP
   Lindsay RS, 2002, LANCET, V360, P57, DOI 10.1016/S0140-6736(02)09335-2
   Loser K, 2010, NAT MED, V16, P713, DOI 10.1038/nm.2150
   Maeda N, 2002, NAT MED, V8, P731, DOI 10.1038/nm724
   Maeda N, 2001, DIABETES, V50, P2094, DOI 10.2337/diabetes.50.9.2094
   Matsuda M, 2002, J BIOL CHEM, V277, P37487, DOI 10.1074/jbc.M206083200
   Matsuzawa Y, 2006, NAT CLIN PRACT CARD, V3, P35, DOI 10.1038/ncpcardio0380
   Matsuzawa Y, 2004, ARTERIOSCL THROM VAS, V24, P29, DOI 10.1161/01.ATV.0000099786.99623.EF
   Morrow DA, 2008, AM HEART J, V155, P49, DOI 10.1016/j.ahj.2007.08.018
   Nagashima K, 2005, J CLIN INVEST, V115, P1323, DOI 10.1172/JCI200523219
   Nawrocki AR, 2010, ARTERIOSCL THROM VAS, V30, P1159, DOI 10.1161/ATVBAHA.109.195826
   Ohashi K, 2007, ARTERIOSCL THROM VAS, V27, P1910, DOI 10.1161/ATVBAHA.107.147645
   Ohashi K, 2010, J BIOL CHEM, V285, P6153, DOI 10.1074/jbc.M109.088708
   Okamoto Y, 2002, CIRCULATION, V106, P2767, DOI 10.1161/01.CIR.0000042707.50032.19
   Okuno A, 1998, J CLIN INVEST, V101, P1354, DOI 10.1172/JCI1235
   Pischon T, 2004, JAMA-J AM MED ASSOC, V291, P1730, DOI 10.1001/jama.291.14.1730
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Truitt KE, 2010, CURR MED RES OPIN, V26, P1321, DOI 10.1185/03007991003715079
   Vogl T, 2007, NAT MED, V13, P1042, DOI 10.1038/nm1638
NR 35
TC 38
Z9 41
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD APR
PY 2011
VL 31
IS 4
BP 792
EP 799
DI 10.1161/ATVBAHA.110.221747
PG 8
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 735SP
UT WOS:000288437800014
PM 21233451
DA 2025-06-11
ER

PT J
AU Janczura, M
   Bochenek, G
   Nowobilski, R
   Dropinski, J
   Kotula-Horowitz, K
   Laskowicz, B
   Stanisz, A
   Lelakowski, J
   Domagala, T
AF Janczura, Miroslaw
   Bochenek, Grazyna
   Nowobilski, Roman
   Dropinski, Jerzy
   Kotula-Horowitz, Katarzyna
   Laskowicz, Bartosz
   Stanisz, Andrzej
   Lelakowski, Jacek
   Domagala, Teresa
TI The Relationship of Metabolic Syndrome with Stress, Coronary Heart
   Disease and Pulmonary Function - An Occupational Cohort-Based Study
SO PLOS ONE
LA English
DT Article
ID INTIMA-MEDIA THICKNESS; INCIDENT CARDIOVASCULAR EVENTS; REDUCED
   LUNG-FUNCTION; PHYSICAL-ACTIVITY; INSULIN-RESISTANCE; ARTERY-DISEASE;
   JOB STRAIN; PSYCHOSOCIAL STRESS; BLOOD-PRESSURE; YOUNG-ADULTS
AB Background and Aims
   Higher levels of stress impact the prevalence of metabolic syndrome (MetS) and coronary heart disease. The association between MetS, impaired pulmonary function and low level of physical activity is still pending assessment in the subjects exposed to stress. The study aimed to examine whether higher levels of stress might be related to MetS and the plaque presence, as well as whether MetS might affect pulmonary function.
   Design and Methods
   The study embraced 235 police officers (mean age 40.97 years) from the south of Poland. The anthropometrics and biochemical variables were measured; MetS was diagnosed using the International Diabetes Federation criteria. Computed tomography coronary angiography of coronary arteries, exercise ECG, measurements of brachial flow-mediated dilation, and carotid artery intima-media thickness were completed. In order to measure the self-perception of stress, 10-item Perceived Stress Scale (PSS-10) was applied. Pulmonary function and physical activity levels were also addressed. Multivariate logistic regression analyses were applied to determine the relationships between: 1/incidence of coronary plaque and MetS per se, MetS components and the number of classical cardiovascular risk factors, 2/perceived stress and MetS, 3/MetS and pulmonary function parameters.
   Results
   Coronary artery atherosclerosis was less associated with MetS (OR = 2.62, 95% CI 1.24-5.52; p = 0.011) than with a co-existence of classical cardiovascular risk factors (OR = 5.67, 95% CI 1.07-29.85, p = 0.03; for 3 risk factors and OR = 9.05; 95% CI 1.24-66.23, p = 0.02; for 6 risk factors, respectively). Perceived stress increased MetS prevalence (OR = 1.07, 95% CI 1.03-1.13; p = 0.03), and impacted coronary plaque prevalence (OR = 1.05, 95% CI 1.001-1.10; p = 0.04). Leisure-time physical activity reduced the chances of developing MetS (OR = 0.98 95% CI 0.96-0.99; p = 0.02). MetS subjects had significantly lower values of certain pulmonary function parameters.
   Conclusions
   Exposure to job-specific stress among police officers increased the prevalence of MetS and impacted coronary plaque presence. MetS subjects had worse pulmonary function parameters. Early-stage, comprehensive therapeutic intervention may reduce overall risk of cardiovascular events and prevent pulmonary function impairment in this specific occupational population.
C1 [Janczura, Miroslaw] John Paul 2 Hosp, Dept Anesthesiol & Intens Pulm Care, Krakow, Poland.
   [Bochenek, Grazyna; Nowobilski, Roman; Dropinski, Jerzy; Kotula-Horowitz, Katarzyna; Domagala, Teresa] Jagiellonian Univ, Sch Med, Dept Internal Med, Krakow, Poland.
   [Nowobilski, Roman] Jagiellonian Univ, Sch Med, Fac Publ Hlth, Unit Rehabil Internal Dis, Krakow, Poland.
   [Laskowicz, Bartosz] John Paul 2 Hosp, Dept Radiol & Diagnost Imaging, Krakow, Poland.
   [Stanisz, Andrzej] Jagiellonian Univ, Sch Med, Dept Bioinformat & Telemed, Krakow, Poland.
   [Lelakowski, Jacek] John Paul 2 Hosp, Inst Cardiol, Dept Electrocardiol, Krakow, Poland.
C3 Jagiellonian University; Jagiellonian University; Jagiellonian
   University; Jagiellonian University; Collegium Medicum Jagiellonian
   University
RP Domagala, T (corresponding author), Jagiellonian Univ, Sch Med, Dept Med Biochem, Krakow, Poland.
EM domagala32@yahoo.com
RI Janczura, Miroslaw/HSE-9726-2023
OI Janczura, Miroslaw/0000-0001-8485-0683; Domagala,
   Teresa/0000-0003-0747-5757
FU Leading National Research Centre
FX Project co-financed by the Leading National Research Centre 2012-2017.
CR Achenbach S, 2008, EUR RADIOL, V18, P1188, DOI 10.1007/s00330-008-0883-3
   Ahluwalia N, 2006, ATHEROSCLEROSIS, V186, P345, DOI 10.1016/j.atherosclerosis.2005.07.021
   Ahmadi A, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0118998
   Ainsworth BE, 2011, MED SCI SPORT EXER, V43, P1575, DOI 10.1249/MSS.0b013e31821ece12
   Al Suwaidi J, 2000, CIRCULATION, V101, P948, DOI 10.1161/01.CIR.101.9.948
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   [Anonymous], 2015, PLOS ONE, DOI 10.1371/journal.pone.0120632
   Arcari A, 2013, EUR J PREV CARDIOL, V20, P862, DOI 10.1177/2047487312447904
   Brotman DJ, 2007, LANCET, V370, P1089, DOI 10.1016/S0140-6736(07)61305-1
   BRUCE RA, 1971, ANN CLIN RES, V3, P323
   Brunner EJ, 2007, AM J EPIDEMIOL, V165, P828, DOI 10.1093/aje/kwk058
   Butler J, 2008, AM J CARDIOL, V101, P1127, DOI 10.1016/j.amjcard.2007.12.012
   Cameron A, 2010, MATURITAS, V65, P117, DOI 10.1016/j.maturitas.2009.11.026
   Can SH, 2014, IND HEALTH, V52, P240, DOI 10.2486/indhealth.2013-0237
   Carson Tiffany L, 2015, J Obes, V2015, P203164, DOI 10.1155/2015/203164
   CELERMAJER DS, 1992, LANCET, V340, P1111, DOI 10.1016/0140-6736(92)93147-F
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Chandola T, 2008, EUR HEART J, V29, P640, DOI 10.1093/eurheartj/ehm584
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   COHEN S, 1988, CLAR SYMP, P31
   Den Ruijter HM, 2012, JAMA-J AM MED ASSOC, V308, P796, DOI 10.1001/jama.2012.9630
   Ezzati M, 2005, CIRCULATION, V112, P489, DOI 10.1161/CIRCULATIONAHA.104.521708
   Fimognari FL, 2007, J GERONTOL A-BIOL, V62, P760, DOI 10.1093/gerona/62.7.760
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   Franke WD, 1998, J OCCUP ENVIRON MED, V40, P441, DOI 10.1097/00043764-199805000-00006
   Fransson EI, 2012, AM J EPIDEMIOL, V176, P1078, DOI 10.1093/aje/kws336
   Galobardes B, 2006, ANN EPIDEMIOL, V16, P91, DOI 10.1016/j.annepidem.2005.06.053
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Grundy SM, 2006, J AM COLL CARDIOL, V47, P1093, DOI 10.1016/j.jacc.2005.11.046
   Guimont C, 2006, AM J PUBLIC HEALTH, V96, P1436, DOI 10.2105/AJPH.2004.057679
   Hamburg NM, 2008, AM J CARDIOL, V101, P82, DOI 10.1016/j.amjcard.2007.07.053
   Hamer M, 2012, PSYCHOSOM MED, V74, P896, DOI 10.1097/PSY.0b013e31827457f4
   Hartley Tara A, 2011, Int J Emerg Ment Health, V13, P243
   Hartley TA, 2011, J OCCUP ENVIRON MED, V53, P553, DOI 10.1097/JOM.0b013e3182171995
   Hsiao FC, 2010, METABOLISM, V59, P848, DOI 10.1016/j.metabol.2009.10.001
   Juonala M, 2004, CIRCULATION, V110, P2918, DOI 10.1161/01.CIR.0000147540.88559.00
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   Kibler JL, 2014, WORLD J CARDIOL, V6, P455, DOI 10.4330/wjc.v6.i6.455
   Kivimäki M, 2006, SCAND J WORK ENV HEA, V32, P431, DOI 10.5271/sjweh.1049
   Konstantinou DM, 2010, METAB SYNDR RELAT D, V8, P201, DOI 10.1089/met.2009.0059
   Koskinen J, 2010, CIRCULATION, V121, P392, DOI 10.1161/CIRCULATIONAHA.109.894584
   Kozey S, 2010, J PHYS ACT HEALTH, V7, P508, DOI 10.1123/jpah.7.4.508
   Kukkonen-Harjula K, 2007, SCAND J WORK ENV HEA, V33, P401, DOI 10.5271/sjweh.1161
   Lee CMY, 2008, DIABETES RES CLIN PR, V81, P377, DOI 10.1016/j.diabres.2008.05.011
   Lee IM, 2012, LANCET, V380, P219, DOI 10.1016/S0140-6736(12)61031-9
   Leone N, 2009, AM J RESP CRIT CARE, V179, P509, DOI 10.1164/rccm.200807-1195OC
   Li J, 2012, INT J ENV RES PUB HE, V9, P391, DOI 10.3390/ijerph9020391
   Lim SY, 2010, J KOREAN MED SCI, V25, P1480, DOI 10.3346/jkms.2010.25.10.1480
   Lin WY, 2006, OBESITY, V14, P1654, DOI 10.1038/oby.2006.190
   Lind L, 2008, ATHEROSCLEROSIS, V196, P795, DOI 10.1016/j.atherosclerosis.2007.01.014
   Mattsson N, 2008, EUR HEART J, V29, P784, DOI 10.1093/eurheartj/ehm576
   McClean KM, 2008, THORAX, V63, P649, DOI 10.1136/thx.2007.086801
   Mellen PB, 2006, ARTERIOSCL THROM VAS, V26, P189, DOI 10.1161/01.ATV.0000191656.71812.7c
   Miller MR, 2005, EUR RESPIR J, V26, P319, DOI 10.1183/09031936.05.00034805
   Mons U, 2014, HEART, V100, P1043, DOI 10.1136/heartjnl-2013-305242
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Nakajima K, 2008, CHEST, V134, P712, DOI 10.1378/chest.07-3003
   Niu L, 2013, PLOS ONE, V8, DOI [10.1371/journal.pone.0067809, DOI 10.1371/ANNOTATION/8941AEE3-4BB8-42A0-B09A-E7C416BEEEF7]
   Oginska-Bulik N, 2009, NARZEDZIA POMIARU ST
   Öhlin B, 2004, EUR HEART J, V25, P867, DOI 10.1016/j.ehj.2004.03.003
   Paek YJ, 2010, METABOLISM, V59, P1300, DOI 10.1016/j.metabol.2009.12.005
   Park HY, 2010, RESP MED, V104, P1326, DOI 10.1016/j.rmed.2010.02.024
   Petersen CB, 2014, PREV MED, V69, P5, DOI 10.1016/j.ypmed.2014.08.022
   Pigna G, 2011, ATHEROSCLEROSIS, V215, P417, DOI 10.1016/j.atherosclerosis.2010.12.038
   Prasad A, 2000, J AM COLL CARDIOL, V36, P1467, DOI 10.1016/S0735-1097(00)00892-5
   Ramey SL, 2011, AAOHN J, V59, P221, DOI 10.3928/08910162-20110418-02
   Rask-Madsen C, 2012, ARTERIOSCL THROM VAS, V32, P2052, DOI 10.1161/ATVBAHA.111.241919
   Rogliani P, 2010, RESP MED, V104, P47, DOI 10.1016/j.rmed.2009.08.009
   Rosengren A, 2004, LANCET, V364, P953, DOI 10.1016/S0140-6736(04)17019-0
   Sattar N, 2008, INT J OBESITY, V32, pS30, DOI 10.1038/ijo.2008.33
   Sattar N, 2008, LANCET, V371, P1927, DOI 10.1016/S0140-6736(08)60602-9
   Scuteri A, 2004, J AM COLL CARDIOL, V43, P1388, DOI 10.1016/j.jacc.2003.10.061
   Sin DD, 2005, CHEST, V127, P1952, DOI 10.1378/chest.127.6.1952
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Steptoe A, 2012, NAT REV CARDIOL, V9, P360, DOI 10.1038/nrcardio.2012.45
   Sundström J, 2006, BMJ-BRIT MED J, V332, P878, DOI 10.1136/bmj.38766.624097.1F
   Sygnowska E, 2012, KARDIOL POL, V70, P718
   Tharkar Shabana, 2008, J Assoc Physicians India, V56, P845
   Thayer JF, 2010, INT J CARDIOL, V141, P122, DOI 10.1016/j.ijcard.2009.09.543
   Title LM, 2008, VASC MED, V13, P263, DOI 10.1177/1358863X08095154
   U. S. Department of Health and Human Services, 2008, PHYS ACT GUID AM
   Violanti John M, 2006, Int J Emerg Ment Health, V8, P227
   Wanahita N, 2010, J OCCUP ENVIRON MED, V52, P661, DOI 10.1097/JOM.0b013e3181e36457
   Wang Z, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0028610
   Wiernik E, 2013, HYPERTENSION, V61, P571, DOI 10.1161/HYPERTENSIONAHA.111.00302
   Wongpakaran N, 2010, BIOPSYCHOSOC MED, V4, DOI 10.1186/1751-0759-4-6
   Yarnell J, 2008, EUR HEART J, V29, P579, DOI 10.1093/eurheartj/ehm641
   Yeboah J, 2009, CIRCULATION, V120, P502, DOI 10.1161/CIRCULATIONAHA.109.864801
   Zdrojewski T, 2013, KARDIOL POL, V71, P381, DOI 10.5603/KP.2013.0066
NR 89
TC 52
Z9 61
U1 1
U2 14
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 14
PY 2015
VL 10
IS 8
AR e0133750
DI 10.1371/journal.pone.0133750
PG 20
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA CO9KD
UT WOS:000359493600016
PM 26274823
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Jiraskova, A
   Skrha, J
   Vitek, L
AF Jiraskova, Alena
   Skrha, Jan
   Vitek, Libor
TI Association of Low Serum Bilirubin Concentrations and Promoter
   Variations in the UGT1A1 and HMOX1 Genes with Type 2
   Diabetes Mellitus in the Czech Population
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE benign hyperbilirubinemia; bilirubin; Gilbert syndrome; heme oxygenase;
   HMOX1; type 2 diabetes mellitus
ID GILBERT-SYNDROME; METABOLIC SYNDROME; OXIDATIVE STRESS; DISEASE;
   POLYMORPHISMS; PREVALENCE
AB Bilirubin has potent biological beneficial effects, protecting against atherosclerosis, obesity, and metabolic syndrome. The aim of this study was to assess serum bilirubin concentrations and (TA)(n) and (GT)(n) microsatellite variations in the promoter regions of the UGT1A1 and HMOX1 genes, respectively, in patients with type 2 diabetes mellitus (T2DM). The study was carried out in 220 patients with T2DM and 231 healthy control subjects, in whom standard biochemical tests were performed. The (TA)(n) and (GT)(n) dinucleotide variations were determined by means of fragment (size-based) analysis using an automated capillary DNA sequencer. Compared to controls, both male and female patients with T2DM had lower serum bilirubin concentrations (9.9 vs. 12.9 & mu;mol/L, and 9.0 vs. 10.6 & mu;mol/L, in men and women, respectively, p < 0.001). Phenotypic Gilbert syndrome was much less prevalent in T2DM patients, as was the frequency of the (TA)(7/7) UGT1A1 genotype in male T2DM patients. (GT)(n) HMOX1 genetic variations did not differ between diabetic patients and controls. Our results demonstrate that the manifestation of T2DM is associated with lower serum bilirubin concentrations. Consumption of bilirubin due to increased oxidative stress associated with T2DM seems to be the main explanation, although (TA)(n) repeat variations in UGT1A1 partially contribute to this phenomenon.
C1 [Jiraskova, Alena; Vitek, Libor] Charles Univ Prague, Gen Univ Hosp Prague, Inst Med Biochem & Lab Diagnost, Fac Med 1, Katerinska 32, Prague 12000, Czech Republic.
   [Skrha, Jan] Charles Univ Prague, Gen Univ Hosp Prague, Fac Med 1, Dept Internal Med 3, Katerinska 32, Prague 12000, Czech Republic.
   [Vitek, Libor] Charles Univ Prague, Gen Univ Hosp Prague, Fac Med 1, Dept Internal Med 4, Katerinska 32, Prague 12000, Czech Republic.
C3 Charles University Prague; General University Hospital Prague; General
   University Hospital Prague; Charles University Prague; General
   University Hospital Prague; Charles University Prague
RP Vitek, L (corresponding author), Charles Univ Prague, Gen Univ Hosp Prague, Inst Med Biochem & Lab Diagnost, Fac Med 1, Katerinska 32, Prague 12000, Czech Republic.
EM alena.jiraskova@immunai.com; jan.skrha@lf1.cuni.cz; vitek@cesnet.cz
RI Vitek, Libor/A-2645-2008
OI Vitek, Libor/0000-0002-5318-0151
FU Czech Ministry of Health [MH CZ-DRO-VFN64165]; Cooperatio Program,
   research area DIAG; National Institute for Research of Metabolic and
   Cardiovascular Diseases - European Union-Next Generation EU
   [LX22NPO5104]
FX This study was supported by grants MH CZ-DRO-VFN64165 from the Czech
   Ministry of Health; Cooperatio Program, research area DIAG given by
   Charles University, and the project National Institute for Research of
   Metabolic and Cardiovascular Diseases (Programme EXCELES LX22NPO5104)
   funded by the European Union-Next Generation EU.
CR Alouffi S, 2023, ELECTRON J GEN MED, V20, DOI 10.29333/ejgm/12777
   Bao W, 2010, AM J EPIDEMIOL, V172, P631, DOI 10.1093/aje/kwq162
   BOSMA PJ, 1995, NEW ENGL J MED, V333, P1171, DOI 10.1056/NEJM199511023331802
   Chen YH, 2008, DIABETES CARE, V31, P1615, DOI 10.2337/dc07-2126
   Choi SH, 2013, NUTR METAB CARDIOVAS, V23, P31, DOI 10.1016/j.numecd.2011.03.001
   Eremiasova L, 2020, CIRC J, V84, P1779, DOI 10.1253/circj.CJ-20-0192
   Exner M, 2004, FREE RADICAL BIO MED, V37, P1097, DOI 10.1016/j.freeradbiomed.2004.07.008
   Fu J, 2022, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.792795
   Fu YY, 2010, TOHOKU J EXP MED, V222, P265, DOI 10.1620/tjem.222.265
   Gordon DM, 2019, PHYSIOL GENOMICS, V51, P234, DOI 10.1152/physiolgenomics.00028.2019
   Inoguchi T, 2007, JAMA-J AM MED ASSOC, V298, P1398, DOI 10.1001/jama.298.12.1398-b
   Jenko-Praznikar Z, 2013, METABOLISM, V62, P976, DOI 10.1016/j.metabol.2013.01.011
   Jin CH, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.948338
   Jirásková A, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/9478946
   Jiraskova A, 2010, CLIN BIOCHEM, V43, P697, DOI 10.1016/j.clinbiochem.2010.01.006
   Ko G T, 1996, J Cardiovasc Risk, V3, P459
   Lee EY, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000001825
   Lin JP, 2010, CLIN CHEM, V56, P1535, DOI 10.1373/clinchem.2010.151043
   Mölzer C, 2016, SCI REP-UK, V6, DOI 10.1038/srep30051
   Novotny L, 2003, EXP BIOL MED, V228, P568, DOI 10.1177/15353702-0322805-29
   Petrtyl J, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10122000
   Schwertner HA, 2008, ATHEROSCLEROSIS, V198, P1, DOI 10.1016/j.atherosclerosis.2008.01.001
   Stec DE, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0153427
   Vítek L, 2017, PHYSIOL RES, V66, pS11, DOI 10.33549/physiolres.933581
   Vítek L, 2002, ATHEROSCLEROSIS, V160, P449, DOI 10.1016/S0021-9150(01)00601-3
   Vitek L, 2023, TRENDS MOL MED, V29, P315, DOI 10.1016/j.molmed.2023.01.007
   Vítek L, 2007, ADV CLIN CHEM, V43, P1, DOI 10.1016/S0065-2423(06)43001-8
   Vítek L, 2021, J HEPATOL, V75, P1485, DOI 10.1016/j.jhep.2021.06.010
   Vítek L, 2020, MED RES REV, V40, P1335, DOI 10.1002/med.21660
   Vitek L, 2019, CLIN PHARMACOL THER, V106, P568, DOI 10.1002/cpt.1341
   Vítek L, 2013, J APPL BIOMED, V11, P209, DOI 10.2478/v10136-012-0030-y
   Vítek L, 2012, FRONT PHARMACOL, V3, DOI 10.3389/fphar.2012.00055
   Wagner KH, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10091474
   Wagner KH, 2015, CLIN SCI, V129, P1, DOI 10.1042/CS20140566
   Wei Y, 2021, DIABETOL METAB SYNDR, V13, DOI 10.1186/s13098-021-00762-0
   Wu YH, 2011, J DIABETES, V3, P217, DOI 10.1111/j.1753-0407.2011.00138.x
   Yao Q, 2019, PHARMACOL RES, V145, DOI 10.1016/j.phrs.2019.104256
   Zhang F, 2020, INT J ENDOCRINOL, V2020, DOI 10.1155/2020/5681296
   Ziberna L, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10091352
   Zucker SD, 2004, HEPATOLOGY, V40, P827, DOI [10.1002/hep.20407, 10.1002/hep.1840400412]
NR 40
TC 2
Z9 2
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL
PY 2023
VL 24
IS 13
AR 10614
DI 10.3390/ijms241310614
PG 9
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA M8WN2
UT WOS:001032964000001
PM 37445792
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Heit, C
   Marshall, S
   Singh, S
   Yu, XQ
   Charkoftaki, G
   Zhao, HY
   Orlicky, DJ
   Fritz, KS
   Thompson, DC
   Vasiliou, V
AF Heit, Claire
   Marshall, Stephanie
   Singh, Surrendra
   Yu, Xiaoqing
   Charkoftaki, Georgia
   Zhao, Hongyu
   Orlicky, David J.
   Fritz, Kristofer S.
   Thompson, David C.
   Vasiliou, Vasilis
TI Catalase deletion promotes prediabetic phenotype in mice
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Catalase; Obesity; Metabolism; Steatosis; Diabetes
ID ADIPOSE-TISSUE DISTRIBUTION; INDUCED HEPATIC STEATOSIS; TYPE-2
   DIABETES-MELLITUS; INSULIN-RESISTANCE; HYDROGEN-PEROXIDE; OXIDATIVE
   STRESS; PPAR-GAMMA; GENE-EXPRESSION; BETA-CELLS; METABOLIC SYNDROME
AB Hydrogen peroxide is produced endogenously and can be toxic to living organisms by inducing oxidative stress and cell damage. However, it has also been identified as a signal transduction molecule. By metabolizing hydrogen peroxide, catalase protects cells and tissues against oxidative damage and may also influence signal transduction mechanisms. Studies suggest that acatalasemic individuals (ie., those with very low catalase activity) have a higher risk for the development of diabetes. We now report catalase knockout (Cat(-/-)) mice, when fed a normal (6.5% lipid) chow, exhibit an obese phenotype that manifests as an increase in body weight that becomes more pronounced with age. The mice demonstrate altered hepatic and muscle lipid deposition, as well as increases in serum and hepatic triglycerides (TGs), and increased hepatic transcription and protein expression of PPAR gamma. Liver morphology revealed steatosis with inflammation. Cat(-/-) mice also exhibited pancreatic morphological changes that correlated with impaired glucose tolerance and increased fasting serum insulin levels, conditions consistent with pre-diabetic status. RNA-seq analyses revealed a differential expression of pathways and genes in Cat(-/)- mice, many of which are related to metabolic syndrome, diabetes, and obesity, such as Pparg and Cidee.
   In conclusion, the results of the present study show mice devoid of catalase develop an obese, pre-diabetic phenotype and provide compelling evidence for catalase (or its products) being integral in metabolic regulation.
C1 [Heit, Claire; Fritz, Kristofer S.] Univ Colorado Denver, Sch Pharm, Dept Pharmaceut Sci, Anschutz Med Campus,12850 East Montview Blvd, Aurora, CO 80045 USA.
   [Marshall, Stephanie; Singh, Surrendra; Charkoftaki, Georgia; Vasiliou, Vasilis] Yale Univ, Yale Sch Publ Hlth, Dept Environm Hlth Serv, 60 Coll St, New Haven, CT 06520 USA.
   [Yu, Xiaoqing; Zhao, Hongyu] Yale Univ, Yale Sch Publ Hlth, Dept Biostat, New Haven, CT 06520 USA.
   [Orlicky, David J.] Univ Colorado, Sch Med, Dept Pathol, Anschutz Med Campus, Aurora, CO USA.
   [Thompson, David C.] Univ Colorado, Sch Pharm, Dept Clin Pharm, Anschutz Med Campus,12850 East Montview Blvd, Aurora, CO 80045 USA.
C3 Children's Hospital Colorado; University of Colorado System; University
   of Colorado Anschutz Medical Campus; Yale University; Yale University;
   University of Colorado System; University of Colorado Anschutz Medical
   Campus; University of Colorado System; University of Colorado Anschutz
   Medical Campus
RP Vasiliou, V (corresponding author), Yale Univ, Yale Sch Publ Hlth, Dept Environm Hlth Serv, 60 Coll St, New Haven, CT 06520 USA.
EM vasilis.vasiliou@yale.edu
RI Zhao, Hongyu/KTH-9411-2024; Charkoftaki, Georgia/AAI-6517-2020; Yu,
   Xiaoqing/E-2388-2013
OI Fritz, Kristofer/0000-0002-1499-6174; vasiliou,
   vasilis/0000-0003-2552-3118
FU NIH grants [AA022057, AA021724]; Cancer Center Support Grant
   [P30CA046934]; NIAAA [F32 FAA023699A]
FX We would like to thank Dr. Ying Chen of Yale School of Public Health and
   Peter Harris of University of Colorado Department of Pharmaceutical
   Science for their assistance, expertise and support with this project.
   This work is supported in part by NIH grants AA022057 (VV), AA021724
   (VV), Cancer Center Support Grant (P30CA046934). SM was supported by the
   NIAAA F32 FAA023699A.
CR Alberts Johnson Lewis., 2002, Garland Science
   Anders S, 2015, BIOINFORMATICS, V31, P166, DOI 10.1093/bioinformatics/btu638
   BAETENS D, 1978, DIABETES, V27, P1, DOI 10.2337/diabetes.27.1.1
   Bai Liang, 2016, Zhejiang Da Xue Xue Bao Yi Xue Ban, V45, P68
   Basciano Heather, 2005, Nutr Metab (Lond), V2, P5, DOI 10.1186/1743-7075-2-5
   Bermúdez V, 2010, AM J THER, V17, P274, DOI 10.1097/MJT.0b013e3181c08081
   Botezelli JD, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-78
   Brunt EM, 1999, AM J GASTROENTEROL, V94, P2467, DOI 10.1111/j.1572-0241.1999.01377.x
   Butler AE, 2003, DIABETES, V52, P2304, DOI 10.2337/diabetes.52.9.2304
   Camhi S L, 1995, New Horiz, V3, P170
   Cavarape A, 2001, J ENDOCRINOL INVEST, V24, P838, DOI 10.1007/BF03343940
   Chen BY, 2009, ARCH MED RES, V40, P241, DOI 10.1016/j.arcmed.2009.03.007
   Chen Y, 2016, SCI REP-UK, V6, DOI 10.1038/srep29743
   Chung SS, 2011, AM J PHYSIOL-ENDOC M, V301, pE912, DOI 10.1152/ajpendo.00120.2011
   Day C, 1999, DIABETIC MED, V16, P179, DOI 10.1046/j.1464-5491.1999.00023.x
   Dedoussis George V Z, 2007, Rev Diabet Stud, V4, P13, DOI 10.1900/RDS.2007.4.13
   Elsner M, 2011, DIABETES, V60, P200, DOI 10.2337/db09-1401
   Evans JL, 2005, ANTIOXID REDOX SIGN, V7, P1040, DOI 10.1089/ars.2005.7.1040
   Francini F, 2010, LIFE SCI, V86, P965, DOI 10.1016/j.lfs.2010.05.005
   Frohnert BI, 2011, OBESITY, V19, P1735, DOI 10.1038/oby.2011.115
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gervois P, 2007, NAT CLIN PRACT ENDOC, V3, P145, DOI 10.1038/ncpendmet0397
   Goodpaster BH, 2000, AM J CLIN NUTR, V71, P885
   Goodpaster BH, 2003, DIABETES CARE, V26, P372, DOI 10.2337/diacare.26.2.372
   Góth L, 2000, LANCET, V356, P1820, DOI 10.1016/S0140-6736(00)03238-4
   Goth Laszlo, 2004, Mol Diagn, V8, P141
   Góth L, 2013, MUTAT RES-REV MUTAT, V753, P147, DOI 10.1016/j.mrrev.2013.08.002
   GRANKVIST K, 1981, BIOCHEM J, V199, P393, DOI 10.1042/bj1990393
   Grimsrud PA, 2008, J BIOL CHEM, V283, P21837, DOI 10.1074/jbc.R700019200
   Groeger G, 2009, ANTIOXID REDOX SIGN, V11, P2655, DOI [10.1089/ars.2009.2728, 10.1089/ARS.2009.2728]
   Ho YS, 2004, J BIOL CHEM, V279, P32804, DOI 10.1074/jbc.M404800200
   Hoehn KL, 2009, P NATL ACAD SCI USA, V106, P17787, DOI 10.1073/pnas.0902380106
   HUMMEL KP, 1966, SCIENCE, V153, P1127, DOI 10.1126/science.153.3740.1127
   Hwang I, 2012, DIABETES, V61, P728, DOI 10.2337/db11-0584
   Ikemura M, 2010, MOL PHARMACEUT, V7, P2069, DOI 10.1021/mp100110c
   INGALLS AM, 1950, J HERED, V41, P317, DOI 10.1093/oxfordjournals.jhered.a106073
   Ruiz-Ojeda FJ, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0152550
   Kikumoto Y., 2010, BIOCH BIOPHYS ACTA, V1802
   Kim D, 2013, GENOME BIOL, V14, DOI 10.1186/gb-2013-14-4-r36
   Klebanov S, 2005, J ENDOCRINOL, V186, P203, DOI 10.1677/joe.1.06150
   Kobayashi K, 2000, METABOLISM, V49, P22, DOI 10.1016/S0026-0495(00)90588-2
   Lanaspa MA, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3434
   Langmead B, 2009, GENOME BIOL, V10, DOI 10.1186/gb-2009-10-3-r25
   Lee YJ, 2012, P NATL ACAD SCI USA, V109, P13656, DOI 10.1073/pnas.1203218109
   Li Q, 2015, J CELL MOL MED, V19, P198, DOI 10.1111/jcmm.12417
   Lubos E, 2011, ANTIOXID REDOX SIGN, V15, P1957, DOI 10.1089/ars.2010.3586
   Maithili Karpaga Selvi Nachimuthu, 2015, Sci Pharm, V83, P159, DOI 10.3797/scipharm.1408-16
   Matsusue K, 2008, CELL METAB, V7, P302, DOI 10.1016/j.cmet.2008.03.003
   MAY JM, 1979, J BIOL CHEM, V254, P9017
   Oliveira JM, 2014, CAN J PHYSIOL PHARM, V92, P613, DOI 10.1139/cjpp-2014-0114
   Morán-Salvador E, 2011, FASEB J, V25, P2538, DOI 10.1096/fj.10-173716
   Murano I, 2008, J LIPID RES, V49, P1562, DOI 10.1194/jlr.M800019-JLR200
   OBrien RM, 1996, PHYSIOL REV, V76, P1109, DOI 10.1152/physrev.1996.76.4.1109
   Park YS, 2016, MEDIAT INFLAMM, V2016, DOI 10.1155/2016/8675905
   Pearson WR, 1997, GENOMICS, V46, P24, DOI 10.1006/geno.1997.4995
   Reuter S, 2010, FREE RADICAL BIO MED, V49, P1603, DOI 10.1016/j.freeradbiomed.2010.09.006
   Rizos C.V., 2016, ARCH TOXICOL
   Robertson RP, 2003, DIABETES, V52, P581, DOI 10.2337/diabetes.52.3.581
   Robinson MD, 2008, BIOSTATISTICS, V9, P321, DOI 10.1093/biostatistics/kxm030
   Robinson MD, 2007, BIOINFORMATICS, V23, P2881, DOI 10.1093/bioinformatics/btm453
   Robinson MD, 2012, GENOME RES, V22, P2489, DOI 10.1101/gr.139055.112
   Robinson MD, 2010, GENOME BIOL, V11, DOI 10.1186/gb-2010-11-3-r25
   Robinson MD, 2010, BIOINFORMATICS, V26, P139, DOI 10.1093/bioinformatics/btp616
   Roma LP, 2009, FREE RADICAL BIO MED, V47, P1386, DOI 10.1016/j.freeradbiomed.2009.08.010
   Takahara S, 1978, Monogr Hum Genet, V10, P205
   Terauchi Y, 2003, J BIOL CHEM, V278, P14284, DOI 10.1074/jbc.M211045200
   Veal EA, 2007, MOL CELL, V26, P1, DOI 10.1016/j.molcel.2007.03.016
   Wu L, 2004, J BIOL CHEM, V279, P12126, DOI 10.1074/jbc.M307097200
   Xu B, 1999, FREE RADICAL BIO MED, V27, P830, DOI 10.1016/S0891-5849(99)00130-6
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yu ST, 2003, J BIOL CHEM, V278, P498, DOI 10.1074/jbc.M210062200
NR 71
TC 52
Z9 60
U1 2
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD FEB
PY 2017
VL 103
BP 48
EP 56
DI 10.1016/j.freeradbiomed.2016.12.011
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA EJ2BJ
UT WOS:000393014600005
PM 27939935
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Peluso, I
   Manafikhi, H
   Reggi, R
   Palmery, M
AF Peluso, Ilaria
   Manafikhi, Husseen
   Reggi, Raffaella
   Palmery, Maura
TI Effects of red wine on postprandial stress: potential implication in
   non-alcoholic fatty liver disease development
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Review
DE Postprandial stress; Red wine; Non-alcoholic fatty liver disease
ID FACTOR-KAPPA-B; PLASMA ANTIOXIDANT CAPACITY; OXYGEN SPECIES GENERATION;
   MODERATE ALCOHOL INTAKE; OXIDATIVE STRESS; ENDOTHELIAL FUNCTION;
   MONONUCLEAR-CELLS; MIXED MEAL; CONSUMPTION; INCREASE
AB Red wine consumption is considered to be protective against oxidative stress. Diet strongly influences non-alcoholic fatty liver disease, which is associated with oxidative stress and is considered the hepatic manifestation of the metabolic syndrome.
   We reviewed the available evidence that investigated the effects of red wine on the postprandial-induced metabolic and oxidative stress in humans.
   After red wine consumption with meal, despite the improvement in non-enzymatic antioxidant capacity and lipoperoxidation markers, the influence of confounding factors such as uric acid should be taken into account. Both uric acid and triglycerides increases, induced by ethanol, could cause liver damage. On the other hand, further researches are required in order to understand the meaning of the induction of antioxidant enzymes by red wine and red wine polyphenols in the context of non-alcoholic fatty liver disease.
   In conclusion, inconsistent and contrasting findings exist regarding the potential benefits of red wine consumption against postprandial stress.
C1 [Peluso, Ilaria] Agr Res Council CRA NUT, Ctr Food & Nutr, I-00178 Rome, Italy.
   [Manafikhi, Husseen; Reggi, Raffaella; Palmery, Maura] Univ Roma La Sapienza, Dept Physiol & Pharmacol V Erspamer, I-00185 Rome, Italy.
C3 Consiglio per la Ricerca in Agricoltura e L'analisi Dell'economia
   Agraria (CREA); Sapienza University Rome
RP Palmery, M (corresponding author), Univ Roma La Sapienza, Dept Physiol & Pharmacol V Erspamer, Ple Aldo Moro 5, I-00185 Rome, Italy.
EM physio_pharm@yahoo.it
RI Peluso, Ilaria/ABE-3399-2021; Peluso, Ilaria/A-8023-2018
OI Peluso, Ilaria/0000-0002-6210-5241
CR Abu-Shanab A, 2010, NAT REV GASTRO HEPAT, V7, P691, DOI 10.1038/nrgastro.2010.172
   Aljada A, 2004, AM J CLIN NUTR, V79, P682
   Augustin LSA, 2004, EPIDEMIOLOGY, V15, P767, DOI 10.1097/01.ede.0000142146.36594.9a
   Avogaro A, 2002, J CLIN ENDOCR METAB, V87, P1233, DOI 10.1210/jc.87.3.1233
   Bantle AE, 2008, METABOLISM, V57, P241, DOI 10.1016/j.metabol.2007.09.007
   Bataille AM, 2012, CLIN PHARMACOL THER, V92, P340, DOI 10.1038/clpt.2012.110
   Belia S, 2014, AM J MED SCI, V348, P30, DOI 10.1097/MAJ.0000000000000191
   Benzie IFF, 1996, ANAL BIOCHEM, V239, P70, DOI 10.1006/abio.1996.0292
   Blackhurst DM, 2006, NUTR METAB CARDIOVAS, V16, P550, DOI 10.1016/j.numecd.2005.09.006
   Blanco-Colio LM, 2000, CIRCULATION, V102, P1020, DOI 10.1161/01.CIR.102.9.1020
   Böhm T, 2013, J HEPATOL, V59, P563, DOI 10.1016/j.jhep.2013.04.025
   Brand-Miller JC, 2007, AM J CLIN NUTR, V85, P1545, DOI 10.1093/ajcn/85.6.1545
   Caccetta RAA, 2001, FREE RADICAL BIO MED, V30, P636, DOI 10.1016/S0891-5849(00)00497-4
   Cao G, 2000, J APPL PHYSIOL, V89, P877, DOI 10.1152/jappl.2000.89.3.877
   Cao GH, 1998, J NUTR, V128, P2383, DOI 10.1093/jn/128.12.2383
   Carvalhana S, 2012, CURR OPIN CLIN NUTR, V15, P468, DOI 10.1097/MCO.0b013e3283566614
   Castilla P, 2008, AM J CLIN NUTR, V87, P1053, DOI 10.1093/ajcn/87.4.1053
   Cederbaum AI, 2006, J GASTROEN HEPATOL, V21, pS22, DOI 10.1111/j.1440-1746.2006.04595.x
   Ceriello A, 1999, DIABETES CARE, V22, P2084, DOI 10.2337/diacare.22.12.2084
   Ceriello A, 2001, EUR J CLIN INVEST, V31, P322, DOI 10.1046/j.1365-2362.2001.00818.x
   Chaves AA, 2009, VASC PHARMACOL, V50, P20, DOI 10.1016/j.vph.2008.08.004
   Chung BH, 2003, AM J CLIN NUTR, V78, P391, DOI 10.1093/ajcn/78.3.391
   Clemente-Postigo M, 2013, AM J CLIN NUTR, V97, P1053, DOI 10.3945/ajcn.112.051128
   Covas MI, 2003, DRUG EXP CLIN RES, V29, P217
   Cowpland C, 2006, CLIN EXP PHARMACOL P, V33, P183, DOI 10.1111/j.1440-1681.2006.04337.x
   Dalgaard M, 2004, METABOLISM, V53, P77, DOI 10.1016/j.metabol.2003.08.011
   DAY A, 1995, CLIN CHEM, V41, P1319
   Dhindsa S, 2004, METABOLISM, V53, P330, DOI 10.1016/j.metabol.2003.10.013
   Di Renzo L, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/681318
   Djoussé L, 1999, AM J CARDIOL, V84, P660, DOI 10.1016/S0002-9149(99)00412-9
   Dunn W, 2008, HEPATOLOGY, V47, P1947, DOI 10.1002/hep.22292
   Ellinger S, 2008, ANN NUTR METAB, V52, P288, DOI 10.1159/000146275
   Fernández-Pachón MS, 2005, J AGR FOOD CHEM, V53, P5024, DOI 10.1021/jf0501995
   Flanagan DEH, 2000, EUR J CLIN INVEST, V30, P297
   Flores-Mateo G, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0105881
   Garcia-Alonso M, 2009, J NUTR BIOCHEM, V20, P521, DOI 10.1016/j.jnutbio.2008.05.011
   Ghanim H, 2011, J CLIN ENDOCR METAB, V96, P1409, DOI 10.1210/jc.2010-1812
   Ghanim H, 2009, DIABETES CARE, V32, P2281, DOI 10.2337/dc09-0979
   GHISELLI A, 1995, FREE RADICAL BIO MED, V18, P29, DOI 10.1016/0891-5849(94)00102-P
   Gorelik S, 2008, J AGR FOOD CHEM, V56, P5002, DOI 10.1021/jf703700d
   Gorelik S, 2008, FASEB J, V22, P41, DOI 10.1096/fj.07-9041com
   Greenfield JR, 2005, J CLIN ENDOCR METAB, V90, P661, DOI 10.1210/jc.2004-1511
   Hampton SM, 2010, J HUM NUTR DIET, V23, P120, DOI 10.1111/j.1365-277X.2009.01021.x
   Hardwick RN, 2010, DRUG METAB DISPOS, V38, P2293, DOI 10.1124/dmd.110.035006
   Hätönen KA, 2012, AM J CLIN NUTR, V96, P44, DOI 10.3945/ajcn.111.031682
   Hausenblas HA, 2015, MOL NUTR FOOD RES, V59, P147, DOI 10.1002/mnfr.201400173
   Hendriks HFJ, 1998, ALCOHOL ALCOHOLISM, V33, P403
   Covas MI, 2010, ATHEROSCLEROSIS, V208, P297, DOI 10.1016/j.atherosclerosis.2009.06.031
   Jhang JJ, 2015, CELL MOL IMMUNOL, V12, P424, DOI 10.1038/cmi.2014.65
   Knasmüller S, 2008, BRIT J NUTR, V99, pES3, DOI 10.1017/S0007114508965752
   Kokavec A, 2003, ALCOHOL CLIN EXP RES, V27, P1718, DOI 10.1097/01.ALC.0000093600.86673.9C
   Laugerette F, 2011, BIOCHIMIE, V93, P39, DOI 10.1016/j.biochi.2010.04.016
   Lettieri-Barbato D, 2013, BRIT J NUTR, V109, P1544, DOI 10.1017/S0007114513000263
   Lieber CS, 2004, HEPATOL RES, V28, P1, DOI 10.1016/j.hepres.2003.08.001
   Mager DR, 2013, JPEN-PARENTER ENTER, V37, P517, DOI 10.1177/0148607112467820
   MAXWELL S, 1994, LANCET, V344, P193, DOI 10.1016/S0140-6736(94)92795-2
   Miglio C, 2013, EUR J NUTR, V52, P1107, DOI 10.1007/s00394-012-0420-7
   Modun D, 2008, ATHEROSCLEROSIS, V197, P250, DOI 10.1016/j.atherosclerosis.2007.04.002
   Mudráková E, 2013, NUTR METAB CARDIOVAS, V23, P183, DOI 10.1016/j.numecd.2011.05.003
   Na HK, 2008, FOOD CHEM TOXICOL, V46, P1271, DOI 10.1016/j.fct.2007.10.006
   Naissides M, 2004, ATHEROSCLEROSIS, V177, P401, DOI 10.1016/j.atherosclerosis.2004.07.025
   Napoli R, 2004, METABOLISM, V53, P1081, DOI 10.1016/j.metabol.2004.02.018
   Natella F, 2001, FREE RADICAL BIO MED, V30, P1036, DOI 10.1016/S0891-5849(01)00504-4
   Natella F, 2011, BRIT J NUTR, V105, P1718, DOI 10.1017/S0007114510005544
   Natella F, 2002, J AGR FOOD CHEM, V50, P7720, DOI 10.1021/jf020346o
   Numminen H, 2000, ALCOHOL ALCOHOLISM, V35, P594, DOI 10.1093/alcalc/35.6.594
   Pal S, 2004, INT J OBESITY, V28, P324, DOI 10.1038/sj.ijo.0802577
   Pastori D, 2015, DIGEST LIVER DIS, V47, P4, DOI 10.1016/j.dld.2014.07.170
   Patel C, 2007, J CLIN ENDOCR METAB, V92, P4476, DOI 10.1210/jc.2007-0778
   Peluso I., 2014, CLIN IMMUNOLOGY ENDO, V1, P27
   Peluso Ilaria, 2012, Endocrine Metabolic & Immune Disorders-Drug Targets, V12, P351
   Peluso I, 2012, CURR PHARM DESIGN, V18, P85, DOI 10.2174/138161212798919020
   Perlemuter G, 2005, LIVER INT, V25, P946, DOI 10.1111/j.1478-3231.2005.01126.x
   Pignatelli P, 2006, ATHEROSCLEROSIS, V188, P77, DOI 10.1016/j.atherosclerosis.2005.10.025
   Piver B, 2001, TOXICOL LETT, V125, P83, DOI 10.1016/S0378-4274(01)00418-0
   Prior RL, 2007, J AM COLL NUTR, V26, P170, DOI 10.1080/07315724.2007.10719599
   Rodrigo R, 2011, CLIN CHIM ACTA, V412, P410, DOI 10.1016/j.cca.2010.11.034
   Ruiz AG, 2007, OBES SURG, V17, P1374
   Schrieks IC, 2013, ALCOHOL ALCOHOLISM, V48, P153, DOI 10.1093/alcalc/ags086
   Shai I, 2007, DIABETES CARE, V30, P3011, DOI 10.2337/dc07-1103
   Sumida Y, 2013, FREE RADICAL RES, V47, P869, DOI 10.3109/10715762.2013.837577
   Tang Y, 2011, CLIN EXP IMMUNOL, V166, P281, DOI 10.1111/j.1365-2249.2011.04471.x
   Thiel G, 2014, MOL NUTR FOOD RES, V58, P1402, DOI 10.1002/mnfr.201300913
   Turner BC, 2001, DIABETES CARE, V24, P1888, DOI 10.2337/diacare.24.11.1888
   Ursini F, 1998, FREE RADICAL BIO MED, V25, P250, DOI 10.1016/S0891-5849(98)00044-6
   Van der Gaag MS, 2000, J WOMEN HEALTH GEN-B, V9, P607, DOI 10.1089/15246090050118134
   Vanni E, 2010, DIGEST LIVER DIS, V42, P320, DOI 10.1016/j.dld.2010.01.016
   Ventura P, 2004, INT J VITAM NUTR RES, V74, P137, DOI 10.1024/0300-9831.74.2.137
   Vespasiani-Gentilucci U, 2015, LIVER INT, V35, P569, DOI 10.1111/liv.12531
   Volynets V, 2012, DIGEST DIS SCI, V57, P1932, DOI 10.1007/s10620-012-2112-9
   Wedick NM, 2012, AM J CLIN NUTR, V95, P925, DOI 10.3945/ajcn.111.028894
   Williams MJA, 2004, METABOLISM, V53, P318, DOI 10.1016/j.metabol.2003.10.012
   Xie YL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0067152
   Cesena FHY, 2011, J CLIN LIPIDOL, V5, P294, DOI 10.1016/j.jacl.2011.04.007
   Zhang JW, 2014, CLIN LAB, V60, P1301, DOI 10.7754/Clin.Lab.2013.130516
   Zhang WF, 2014, ANN HEPATOL, V13, P489, DOI 10.1016/S1665-2681(19)31247-5
   Zhu LX, 2013, HEPATOLOGY, V57, P601, DOI 10.1002/hep.26093
NR 97
TC 10
Z9 10
U1 2
U2 25
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD JUN
PY 2015
VL 54
IS 4
BP 497
EP 507
DI 10.1007/s00394-015-0877-2
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CI4KG
UT WOS:000354716500001
PM 25772634
DA 2025-06-11
ER

PT J
AU Wolk, R
   Shamsuzzaman, ASM
   Somers, VK
AF Wolk, R
   Shamsuzzaman, ASM
   Somers, VK
TI Obesity, sleep apnea, and hypertension
SO HYPERTENSION
LA English
DT Review
DE hypertension, obesity; sleep apnea syndromes; sympathetic nervous
   system; insulin resistance
ID POSITIVE AIRWAY PRESSURE; C-REACTIVE PROTEIN; ENDOTHELIUM-DEPENDENT
   VASODILATION; SYMPATHETIC-NERVOUS-SYSTEM; INDEPENDENT RISK-FACTOR;
   BLOOD-PRESSURE; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; NEURAL MECHANISMS
AB Obesity has a high and rising prevalence and represents a major public health problem. Obstructive sleep apnea ( OSA) is also common, affecting an estimated 15 million Americans, with a prevalence that is probably also rising as a consequence of increasing obesity. Epidemiologic data support a link between obesity and hypertension as well as between OSA and hypertension. For example, untreated OSA predisposes to an increased risk of new hypertension, and treatment of OSA lowers blood pressure, even during the daytime. Possible mechanisms whereby OSA may contribute to hypertension in obese individuals include sympathetic activation, hyperleptinemia, insulin resistance, elevated angiotensin II and aldosterone levels, oxidative and inflammatory stress, endothelial dysfunction, impaired baroreflex function, and perhaps by effects on renal function. The coexistence of OSA and obesity may have more widespread implications for cardiovascular control and dysfunction in obese individuals and may contribute to some of the clustering of abnormalities broadly defined as the metabolic syndrome. From the clinical and therapeutic perspectives, the presence of resistant hypertension and the absence of a nocturnal decrease in blood pressure in obese individuals should prompt the clinician to consider the diagnosis of OSA, especially if clinical symptoms suggestive of OSA ( such as poor sleep quality, witnessed apnea, excessive daytime somnolence, and so forth) are also present.
C1 Mayo Clin, Rochester, MN USA.
C3 Mayo Clinic
RP St Marys Hosp, Mayo Fdn, DO-4-350,1216 2nd St SW, Rochester, MN 55902 USA.
EM somers.virend@mayo.edu
CR Abate N, 2000, J DIABETES COMPLICAT, V14, P154, DOI 10.1016/S1056-8727(00)00067-2
   Aizawa-Abe M, 2000, J CLIN INVEST, V105, P1243, DOI 10.1172/JCI8341
   Al Suwaidi J, 2001, J AM COLL CARDIOL, V37, P1523, DOI 10.1016/S0735-1097(01)01212-8
   Alvarez GE, 2002, CIRCULATION, V106, P2533, DOI 10.1161/01.CIR.0000041244.79165.25
   Bautista LE, 2001, J HYPERTENS, V19, P857, DOI 10.1097/00004872-200105000-00004
   Becker HF, 2003, CIRCULATION, V107, P68, DOI 10.1161/01.CIR.0000042706.47107.7A
   Beske SD, 2002, AM J PHYSIOL-HEART C, V282, pH630, DOI 10.1152/ajpheart.00642.2001
   BRAY GA, 1989, VITAM HORM, V45, P1
   BRAY GA, 1991, PROG OBES R, P61
   Carlson JT, 1996, AM J RESP CRIT CARE, V154, P1490, DOI 10.1164/ajrccm.154.5.8912770
   Carlyle M, 2002, HYPERTENSION, V39, P496, DOI 10.1161/hy0202.104398
   Carr MC, 2003, J CLIN ENDOCR METAB, V88, P2404, DOI 10.1210/jc.2003-030242
   Chin KZ, 1999, CIRCULATION, V100, P706, DOI 10.1161/01.CIR.100.7.706
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   Considine RV, 1996, NEW ENGL J MED, V334, P292, DOI 10.1056/NEJM199602013340503
   Dancey DR, 2001, CHEST, V120, P151, DOI 10.1378/chest.120.1.151
   Das UN, 2001, NUTRITION, V17, P953, DOI 10.1016/S0899-9007(01)00672-4
   Dobrian AD, 2001, HYPERTENSION, V37, P554, DOI 10.1161/01.HYP.37.2.554
   Dyugovskaya L, 2002, AM J RESP CRIT CARE, V165, P934, DOI 10.1164/ajrccm.165.7.2104126
   Engeli S, 2001, J MOL MED, V79, P21, DOI 10.1007/s001090000144
   Faccenda JF, 2001, AM J RESP CRIT CARE, V163, P344, DOI 10.1164/ajrccm.163.2.2005037
   GARRISON RJ, 1987, PREV MED, V16, P235, DOI 10.1016/0091-7435(87)90087-9
   Grassi G, 2000, HYPERTENSION, V36, P538, DOI 10.1161/01.HYP.36.4.538
   GRASSI G, 1995, HYPERTENSION, V25, P560, DOI 10.1161/01.HYP.25.4.560
   Hall J E, 2000, Curr Hypertens Rep, V2, P139, DOI 10.1007/s11906-000-0073-4
   Hall JE, 1999, ANN NY ACAD SCI, V892, P91, DOI 10.1111/j.1749-6632.1999.tb07788.x
   Halli RW, 1997, ANQ-Q J SHORT ART N, V10, P55
   Higashi Y, 2001, AM J HYPERTENS, V14, P1038, DOI 10.1016/S0895-7061(01)02191-4
   Ip MSM, 2002, AM J RESP CRIT CARE, V165, P670, DOI 10.1164/ajrccm.165.5.2103001
   Ip MSM, 2000, AM J RESP CRIT CARE, V162, P2166, DOI 10.1164/ajrccm.162.6.2002126
   JONES DW, 1994, J HYPERTENS, V12, P1433, DOI 10.1097/00004872-199412000-00018
   KANNEL WB, 1967, ANN INTERN MED, V67, P48, DOI 10.7326/0003-4819-67-1-48
   Kannel WB, 1999, AM HEART J, V138, pS205, DOI 10.1016/S0002-8703(99)70311-X
   KASSAB S, 1995, HYPERTENSION, V25, P893, DOI 10.1161/01.HYP.25.4.893
   Kato M, 2000, CIRCULATION, V102, P2607
   Kuczmarski RJ, 2000, AM J CLIN NUTR, V72, P1074
   Lerman LO, 2001, HYPERTENSION, V37, P541, DOI 10.1161/01.HYP.37.2.541
   Mark AL, 2002, J HYPERTENS, V20, P1245, DOI 10.1097/00004872-200207000-00001
   Moller DS, 2003, AM J HYPERTENS, V16, P274, DOI 10.1016/S0895-7061(02)03267-3
   Narkiewicz K, 1998, CIRCULATION, V98, P772, DOI 10.1161/01.CIR.98.8.772
   Narkiewicz K, 1998, CIRCULATION, V98, P1071, DOI 10.1161/01.CIR.98.11.1071
   Narkiewicz K, 1998, HYPERTENSION, V32, P1039, DOI 10.1161/01.HYP.32.6.1039
   Nieto FJ, 2000, JAMA-J AM MED ASSOC, V283, P1829, DOI 10.1001/jama.283.14.1829
   O'Donnell CP, 2000, RESP PHYSIOL, V119, P163, DOI 10.1016/S0034-5687(99)00111-5
   Parati G, 1997, J HYPERTENS, V15, P1621, DOI 10.1097/00004872-199715120-00063
   Parati G, 1998, J HYPERTENS, V16, pS25
   Parrinello G, 1996, AM J HYPERTENS, V9, P1186, DOI 10.1016/S0895-7061(96)00259-2
   Peker Y, 2002, AM J RESP CRIT CARE, V166, P159, DOI 10.1164/rccm.2105124
   Peppard PE, 2000, JAMA-J AM MED ASSOC, V284, P3015, DOI 10.1001/jama.284.23.3015
   Peppard PE, 2000, NEW ENGL J MED, V342, P1378, DOI 10.1056/NEJM200005113421901
   Pepperell JCT, 2002, LANCET, V359, P204, DOI 10.1016/S0140-6736(02)07445-7
   Perticone F, 2001, DIABETES, V50, P159, DOI 10.2337/diabetes.50.1.159
   Phillips BG, 1999, J HYPERTENS, V17, P1297, DOI 10.1097/00004872-199917090-00009
   Phillips BG, 2000, AM J PHYSIOL-HEART C, V279, pH234, DOI 10.1152/ajpheart.2000.279.1.H234
   Pickering TG, 2001, CURR OPIN NEPHROL HY, V10, P611, DOI 10.1097/00041552-200109000-00010
   Poirier B, 2000, NEPHROL DIAL TRANSPL, V15, P467, DOI 10.1093/ndt/15.4.467
   Punjabi NM, 2002, AM J RESP CRIT CARE, V165, P677, DOI 10.1164/ajrccm.165.5.2104087
   Rahmouni K, 2002, HYPERTENSION, V39, P486, DOI 10.1161/hy0202.102836
   Reckelhoff JF, 2003, AM J PHYSIOL-REG I, V284, pR893, DOI 10.1152/ajpregu.00491.2002
   Rumantir MS, 1999, J HYPERTENS, V17, P1125, DOI 10.1097/00004872-199917080-00012
   Sasaki S, 2002, AM J HYPERTENS, V15, P302, DOI 10.1016/S0895-7061(01)02322-6
   SCHERRER U, 1994, CIRCULATION, V89, P2634, DOI 10.1161/01.CIR.89.6.2634
   Schulz R, 2000, AM J RESP CRIT CARE, V162, P566, DOI 10.1164/ajrccm.162.2.9908091
   SCHWARTZ AR, 1991, AM REV RESPIR DIS, V144, P494, DOI 10.1164/ajrccm/144.3_Pt_1.494
   Shamsuzzaman ASM, 2002, CIRCULATION, V105, P2462, DOI 10.1161/01.CIR.0000018948.95175.03
   Shek EW, 1998, HYPERTENSION, V31, P409, DOI 10.1161/01.HYP.31.1.409
   Singh JP, 1998, HYPERTENSION, V32, P293, DOI 10.1161/01.HYP.32.2.293
   SMITH PL, 1985, ANN INTERN MED, V103, P850, DOI 10.7326/0003-4819-103-6-850
   Somers M J, 1999, Curr Hypertens Rep, V1, P102, DOI 10.1007/s11906-999-0080-z
   Somers VK, 1999, J HYPERTENS, V17, P1061, DOI 10.1097/00004872-199917080-00003
   SOMERS VK, 1995, J CLIN INVEST, V96, P1897, DOI 10.1172/JCI118235
   Sung KC, 2003, AM J HYPERTENS, V16, P429, DOI 10.1016/S0895-7061(03)00566-1
   Tishler PV, 2003, JAMA-J AM MED ASSOC, V289, P2230, DOI 10.1001/jama.289.17.2230
   TROISI RJ, 1991, HYPERTENSION, V17, P669, DOI 10.1161/01.HYP.17.5.669
   TUCK ML, 1992, HYPERTENSION, V19, pI67, DOI 10.1161/01.HYP.19.1_Suppl.I67
   Vaz M, 1997, CIRCULATION, V96, P3423
   VGONTZAS AN, 1994, ARCH INTERN MED, V154, P1705, DOI 10.1001/archinte.154.15.1705
   Wilcox CS, 2002, CURR HYPERTENS REP, V4, P160, DOI 10.1007/s11906-002-0041-2
   Wilcox I, 1998, THORAX, V53, pS25
   Wyss JM, 2003, CURR HYPERTENS REP, V5, P241, DOI 10.1007/s11906-003-0027-8
   Young T, 2002, AM J RESP CRIT CARE, V165, P1217, DOI 10.1164/rccm.2109080
   Young T, 2003, AM J RESP CRIT CARE, V167, P1181, DOI 10.1164/rccm.200209-1055OC
   YOUNG T, 1993, NEW ENGL J MED, V328, P1230, DOI 10.1056/NEJM199304293281704
   ZHANG YY, 1994, NATURE, V372, P425, DOI 10.1038/372425a0
NR 84
TC 354
Z9 407
U1 1
U2 29
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD DEC
PY 2003
VL 42
IS 6
BP 1067
EP 1074
DI 10.1161/01.HYP.0000101686.98973.A3
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 752TR
UT WOS:000187183700001
PM 14610096
OA Bronze
DA 2025-06-11
ER

PT J
AU Foss, B
   Dyrstad, SM
AF Foss, Brynjar
   Dyrstad, Sindre M.
TI Stress in obesity: Cause or consequence?
SO MEDICAL HYPOTHESES
LA English
DT Article
ID PITUITARY-ADRENAL-AXIS; LOW-GRADE INFLAMMATION; METABOLIC SYNDROME;
   EATING BEHAVIOR; ABDOMINAL OBESITY; CORTISOL; WOMEN; PERSPECTIVE;
   ILLNESS; LEPTIN
AB Obesity is a global public health challenge that increases the risk of various diseases including type 2 diabetes mellitus, hypertension and cancer, and will in the future cause further increases in the incidence of chronic disease. Understanding the mechanisms of obesity is critical if we are to prevent and treat this pandemic challenge. Diet and physical activity have traditionally been the major tasks in preventing and treating obesity. However, other mechanisms are now also being considered in the quest for knowledge and understanding of obesity, including the body's stress system and cortisol release. While it seems evident that stress is a cause of obesity, whether stress is also a consequence of obesity has up to now only briefly been discussed. The aim of this article is to elucidate how stress and obesity might be linked and discuss the cause/consequence relationship between the stress response and obesity. Our hypothesis is that stress and obesity interfere by positive feedback. This may be an important issue in both our understanding and coping of obesity. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Foss, Brynjar] Univ Stavanger, Dept Hlth Studies, N-4036 Stavanger, Norway.
   [Dyrstad, Sindre M.] Univ Stavanger, Dept Educ, N-4036 Stavanger, Norway.
C3 Universitetet i Stavanger; Universitetet i Stavanger
RP Foss, B (corresponding author), Univ Stavanger, Dept Hlth Studies, N-4036 Stavanger, Norway.
EM brynjar.foss@uis.no
RI Dyrstad, Sindre/HLX-1452-2023
OI Foss, Brynjar/0000-0002-3182-4497; Dyrstad, Sindre
   M./0000-0002-7862-2657
CR Anagnostis P, 2009, J CLIN ENDOCR METAB, V94, P2692, DOI 10.1210/jc.2009-0370
   Björntorp P, 2000, NUTRITION, V16, P924, DOI 10.1016/S0899-9007(00)00422-6
   Bose M, 2009, CURR OPIN ENDOCRINOL, V16, P340, DOI 10.1097/MED.0b013e32832fa137
   Boyle CD, 2008, CURR OPIN DRUG DISC, V11, P495
   Cancello R, 2006, BJOG-INT J OBSTET GY, V113, P1141, DOI 10.1111/j.1471-0528.2006.01004.x
   Charmandari E, 2005, ANNU REV PHYSIOL, V67, P259, DOI 10.1146/annurev.physiol.67.040403.120816
   De Vriendt T, 2009, NUTR METAB CARDIOVAS, V19, P511, DOI 10.1016/j.numecd.2009.02.009
   Dockray S, 2009, J ADOLESCENT HEALTH, V45, P344, DOI 10.1016/j.jadohealth.2009.06.014
   Drapeau V, 2003, PANMINERVA MED, V45, P189
   Duclos M, 2005, OBES RES, V13, P1157, DOI 10.1038/oby.2005.137
   Friedman JM, 2004, NAT MED, V10, P563, DOI 10.1038/nm0604-563
   GALVAOTELES A, 1976, ACTA ENDOCRINOL-COP, V81, P321, DOI 10.1530/acta.0.0810321
   George SA, 2010, PSYCHONEUROENDOCRINO, V35, P607, DOI 10.1016/j.psyneuen.2009.09.017
   Ghizzoni L, 2001, J CLIN ENDOCR METAB, V86, P3729, DOI 10.1210/jc.86.8.3729
   Gluck ME, 2004, ANN NY ACAD SCI, V1032, P202, DOI 10.1196/annals.1314.021
   Holmes ME, 2010, OBES REV, V11, P492, DOI 10.1111/j.1467-789X.2009.00680.x
   Kraak VI, 2010, J AM DIET ASSOC, V110, P192, DOI 10.1016/j.jada.2009.10.036
   Kuo LE, 2007, NAT MED, V13, P803, DOI 10.1038/nm1611
   Lamberts SWJ, 1997, NEW ENGL J MED, V337, P1285, DOI 10.1056/NEJM199710303371807
   MAFFEI M, 1995, NAT MED, V1, P1155, DOI 10.1038/nm1195-1155
   Mastorakos George, 2005, Hormones (Athens), V4, P73
   Newman E, 2007, PSYCHONEUROENDOCRINO, V32, P125, DOI 10.1016/j.psyneuen.2006.11.006
   Nieuwenhuizen AG, 2008, PHYSIOL BEHAV, V94, P169, DOI 10.1016/j.physbeh.2007.12.011
   Nishitani N, 2009, NUTRITION, V25, P45, DOI 10.1016/j.nut.2008.07.008
   OCONNELL M, 1973, J CLIN ENDOCR METAB, V36, P323, DOI 10.1210/jcem-36-2-323
   Pasquali R, 2008, INT J OBESITY, V32, P1764, DOI 10.1038/ijo.2008.129
   Tam CS, 2010, OBES REV, V11, P118, DOI 10.1111/j.1467-789X.2009.00674.x
   Torres SJ, 2007, NUTRITION, V23, P887, DOI 10.1016/j.nut.2007.08.008
   Travison TG, 2007, CLIN ENDOCRINOL, V67, P71, DOI 10.1111/j.1365-2265.2007.02837.x
   Vicennati V, 2009, OBESITY, V17, P1678, DOI 10.1038/oby.2009.76
   Wallerius S, 2003, J ENDOCRINOL INVEST, V26, P616, DOI 10.1007/BF03347017
NR 31
TC 87
Z9 109
U1 1
U2 65
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
J9 MED HYPOTHESES
JI Med. Hypotheses
PD JUL
PY 2011
VL 77
IS 1
BP 7
EP 10
DI 10.1016/j.mehy.2011.03.011
PG 4
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 788FM
UT WOS:000292430800004
PM 21444159
DA 2025-06-11
ER

PT J
AU Li, A
   Tang, Z
   Zhu, PJ
   van den Bosch, F
   Chen, YT
   Xu, SL
   Tjakkes, GHE
AF Li, An
   Tang, Zhi
   Zhu, Peijun
   van den Bosch, Florien
   Chen, Yuntao
   Xu, Shulan
   Tjakkes, Geerten-Has E.
TI Serum Antioxidant Vitamins Mediate the Association between Periodontitis
   and Metabolically Unhealthy Overweight/Obesity
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; overweight and obesity; periodontitis; serum
   antioxidants; systemic inflammation
ID ADIPOSE-TISSUE; OXIDATIVE STRESS; HEALTHY OBESE; INFLAMMATION; RISK;
   POPULATION; PREVALENCE; CONSEQUENCES; THERAPY; DISEASE
AB Background: Periodontal disease is associated with metabolic syndrome and obesity. This cross-sectional study aimed to investigate whether serum antioxidant vitamins could mediate the association between periodontitis and a metabolically unhealthy phenotype in the overweight and obese population; Methods: We included 6158 Americans (body mass index (BMI) >= 25 kg/m(2)) from the Third National Health and Nutrition Examination Survey (NHANES III). Periodontitis was defined using a half-reduced CDC/AAP (Centers for Disease Control and Prevention/American Academy of Periodontology) definition. Having two or more metabolic abnormalities was defined as a metabolically unhealthy overweight and obese (MUO) phenotype. Mediation analysis of four oxidative stress biomarkers (serum antioxidant vitamins A, C, D, and E) was conducted; Results: Of participants with overweight and obesity, 2052 (33.3%) Americans were categorized as having periodontitis. Periodontitis increased dyslipidemia risk and systemic inflammation in the overweight and obese population. In the multivariable logistic regression model, periodontitis was positively associated with MUO (adjusted odds ratio = 1.238; 95% confidence interval: 1.091 to 1.406). These findings were validated in an independent cohort. Serum vitamins C and D were estimated to mediate 19.3% and 8.4% of the periodontitis-MUO association. Conclusions: Periodontitis might decrease serum vitamins C and D and induce a metabolically unhealthy state among adults with overweight and obesity.
C1 [Li, An; Zhu, Peijun; Xu, Shulan] Southern Med Univ, Stomatol Hosp, Ctr Oral Implantol, Guangzhou 510280, Peoples R China.
   [Li, An; van den Bosch, Florien; Tjakkes, Geerten-Has E.] Univ Groningen, Univ Med Ctr Groningen UMCG, Ctr Dent & Oral Hyg, Dept Periodontol, NL-9713 AV Groningen, Netherlands.
   [Tang, Zhi] Southern Med Univ, Zhujiang Hosp, Dept Stomatol, Guangzhou 510280, Peoples R China.
   [Chen, Yuntao] UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England.
   [Chen, Yuntao] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Med Stat & Decis Making, NL-9713 AV Groningen, Netherlands.
C3 Southern Medical University - China; University of Groningen; Southern
   Medical University - China; University of London; University College
   London; University of Groningen
RP Xu, SL (corresponding author), Southern Med Univ, Stomatol Hosp, Ctr Oral Implantol, Guangzhou 510280, Peoples R China.
EM xushulan_672588@smu.edu.cn
RI Li, An/AAW-8494-2021; Xu, shulan/GZM-8844-2022
OI Li, An/0000-0001-5750-526X; Chen, Simon/0000-0002-2536-3524
FU Science Research Cultivation Program of Stomatological Hospital,
   Southern Medical University, China [PY2021007]; Clinical Research
   Initiation Plan of Stomatological Hospital, Southern Medical University,
   China [KQIIT2021001]
FX This research was funded by the Science Research Cultivation Program of
   Stomatological Hospital, Southern Medical University, China (No.
   PY2021007) and the Clinical Research Initiation Plan of Stomatological
   Hospital, Southern Medical University, China (No. KQIIT2021001).
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Akinyemiju T, 2018, OBESITY, V26, P193, DOI 10.1002/oby.22067
   Al-khalidi B, 2019, CLIN NUTR, V38, P820, DOI 10.1016/j.clnu.2018.02.025
   Al-Rawi N, 2017, J DIABETES RES, V2017, DOI 10.1155/2017/2643079
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Altay U, 2013, J PERIODONTOL, V84, P13, DOI 10.1902/jop.2012.110646
   Benn M, 2023, CARDIOVASC RES, V118, P3576, DOI 10.1093/cvr/cvab368
   Blüher M, 2010, CURR OPIN LIPIDOL, V21, P38, DOI 10.1097/MOL.0b013e3283346ccc
   Brock GR, 2004, J CLIN PERIODONTOL, V31, P515, DOI 10.1111/j.1600-051X.2004.00509.x
   Bullon P, 2014, PERIODONTOL 2000, V64, P139, DOI 10.1111/j.1600-0757.2012.00455.x
   Colas R, 2011, DIABETOLOGIA, V54, P2931, DOI 10.1007/s00125-011-2272-8
   Costacurta M, 2022, NUTRIENTS, V14, DOI 10.3390/nu14102002
   Dai HJ, 2020, PLOS MED, V17, DOI 10.1371/journal.pmed.1003198
   Eke PI, 2012, J PERIODONTOL, V83, P1449, DOI 10.1902/jop.2012.110664
   Ezzati T M, 1992, Vital Health Stat 2, P1
   Farhangi MA, 2017, INFLAMMATION, V40, P1688, DOI 10.1007/s10753-017-0610-9
   Framke E, 2020, EUR HEART J, V41, P1164, DOI 10.1093/eurheartj/ehz870
   Gómez-Ambrosi J, 2014, DIABETES CARE, V37, P2813, DOI 10.2337/dc14-0937
   Gossweiler AG, 2020, MONOGR ORAL SCI, V28, P59, DOI 10.1159/000455372
   Grenier D, 2016, J PERIODONTAL RES, V51, P359, DOI 10.1111/jre.12315
   Gunawardena HP, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/9471697
   Hajishengallis G, 2021, NAT REV IMMUNOL, V21, P426, DOI 10.1038/s41577-020-00488-6
   Herrera-Balandrano DD, 2021, REDOX BIOL, V46, DOI 10.1016/j.redox.2021.102100
   Hinnouho GM, 2015, EUR HEART J, V36, P551, DOI 10.1093/eurheartj/ehu123
   Jepsen S, 2020, PERIODONTOL 2000, V83, P125, DOI 10.1111/prd.12326
   Jih J, 2014, PREV MED, V65, P1, DOI 10.1016/j.ypmed.2014.04.010
   Jimenez M, 2012, OBESITY, V20, P1718, DOI 10.1038/oby.2011.291
   Jung CH, 2015, J CLIN ENDOCR METAB, V100, P934, DOI 10.1210/jc.2014-3885
   Kataoka K, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17111907
   Kinane DF, 2017, NAT REV DIS PRIMERS, V3, DOI 10.1038/nrdp.2017.38
   Kumar J, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00693
   Kweon S, 2014, INT J EPIDEMIOL, V43, P69, DOI 10.1093/ije/dyt228
   Lakkis D, 2012, J PERIODONTOL, V83, P684, DOI 10.1902/jop.2011.110230
   Li A, 2022, J PERIODONTOL, V93, P1302, DOI 10.1002/JPER.21-0620
   Li A, 2022, J PERIODONTOL, V93, P888, DOI 10.1002/JPER.21-0292
   Li A, 2021, J GERONTOL A-BIOL, V76, P1309, DOI 10.1093/gerona/glaa223
   Lim U, 2019, GASTROENTEROLOGY, V156, P966, DOI 10.1053/j.gastro.2018.11.021
   López NJ, 2012, J PERIODONTOL, V83, P267, DOI 10.1902/jop.2011.110227
   Manna P, 2017, ARCH BIOCHEM BIOPHYS, V615, P22, DOI 10.1016/j.abb.2017.01.002
   Martinon P, 2021, J CLIN MED, V10, DOI 10.3390/jcm10020197
   Montero E, 2021, J CLIN PERIODONTOL, V48, P38, DOI 10.1111/jcpe.13391
   Aguilera EM, 2021, J INTERN MED, V289, P532, DOI 10.1111/joim.13180
   Nebel D, 2015, J PERIODONTAL RES, V50, P666, DOI 10.1111/jre.12249
   Orlandi M, 2022, J CLIN PERIODONTOL, V49, P314, DOI 10.1111/jcpe.13554
   Ouchi N, 2011, NAT REV IMMUNOL, V11, P85, DOI 10.1038/nri2921
   Papageorgiou SN, 2015, J CLIN PERIODONTOL, V42, P247, DOI 10.1111/jcpe.12365
   Park YM, 2016, INT J OBESITY, V40, P1541, DOI 10.1038/ijo.2016.114
   Park YMM, 2019, CLIN NUTR, V38, P682, DOI 10.1016/j.clnu.2018.04.002
   Ranasinghe P, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4041-1
   Romandini M, 2020, J CLIN PERIODONTOL, V47, P429, DOI 10.1111/jcpe.13248
   Sharma P, 2021, J CLIN PERIODONTOL, V48, P357, DOI 10.1111/jcpe.13414
   Smith GI, 2019, J CLIN INVEST, V129, P3978, DOI 10.1172/JCI129186
   Sniderman AD, 2007, INT J EPIDEMIOL, V36, P220, DOI 10.1093/ije/dyl245
   Stefan N, 2020, LANCET DIABETES ENDO, V8, P616, DOI 10.1016/S2213-8587(20)30110-8
   Sun XY, 2017, J CLIN PERIODONTOL, V44, P463, DOI 10.1111/jcpe.12711
   Szymczak-Pajor I, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020956
   Vo TTT, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9121211
   Tran DT, 2014, J CLIN PERIODONTOL, V41, P846, DOI 10.1111/jcpe.12285
   Veljovic T, 2022, J CLIN MED, V11, DOI 10.3390/jcm11133617
   Ward ZJ, 2019, NEW ENGL J MED, V381, P2440, DOI 10.1056/NEJMsa1909301
   Wildman RP, 2008, ARCH INTERN MED, V168, P1617, DOI 10.1001/archinte.168.15.1617
   Winn DM, 1999, J PUBLIC HEALTH DENT, V59, P73, DOI 10.1111/j.1752-7325.1999.tb03238.x
   Zembic A, 2021, JAMA NETW OPEN, V4, DOI 10.1001/jamanetworkopen.2021.8505
   Zuza EC, 2020, J PERIODONTOL, V91, P1123, DOI 10.1002/JPER.19-0534
NR 64
TC 5
Z9 6
U1 3
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2022
VL 14
IS 22
AR 4939
DI 10.3390/nu14224939
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 6K8OE
UT WOS:000887753300001
PM 36432625
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pattnaik, B
   Bodas, M
   Bhatraju, NK
   Ahmad, T
   Pant, R
   Guleria, R
   Ghosh, B
   Agrawal, A
AF Pattnaik, Bijay
   Bodas, Manish
   Bhatraju, Naveen Kumar
   Ahmad, Tanveer
   Pant, Richa
   Guleria, Randeep
   Ghosh, Balaram
   Agrawal, Anurag
TI IL-4 promotes asymmetric dimethylarginine accumulation, oxo-nitrative
   stress, and hypoxic response-induced mitochondrial loss in airway
   epithelial cells
SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
LA English
DT Article
DE IL-4; ADMA; hypoxic response; mitochondrial transcription factor A;
   mitochondria
ID TRANSCRIPTION FACTOR-A; METABOLIC SYNDROME; ARGININE METABOLISM; COPY
   NUMBER; ASTHMA; INFLAMMATION; EXPRESSION; MODEL
AB Background: Obesity is known to increase asthma risk and severity. Increased levels of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, are associated with mitochondrial toxicity, asthma, and metabolic syndrome. IL-4 upregulates the expression of protein arginine methyltransferases, which are essential for ADMA formation. Importantly, cross-talk between IL-4, ADMA, and mitochondrial dysfunction could explain how obesity and IL-4 can synergize to exacerbate allergic inflammation.
   Objective: We sought to investigate how IL-4, a key asthma-associated cytokine, can influenceADMA-related effects on lungs.
   Methods: BEAS2B (bronchial epithelial) cells were treated with IL-4 followed by ADMA and investigated for oxo-nitrative stress and resultant mitochondrial toxicity after 48 hours by using flow cytometry, confocal imaging, immunoblotting, and fluorimetric assays.
   Results: IL-4-induced mitotoxicity in BEAS2B cells was significantly higher in the presence of exogenous ADMA. IL-4 treatment led to proteolytic degradation of dimethylarginine dimethylaminohydrolase 2, which catabolizes ADMA. IL-4 pretreatment was associated with increased intracellular ADMA accumulation and increased ADMA-induced mitotoxicity. Airway epithelial cells treated with IL-4 followed by ADMA showed exaggerated oxo-nitrative stress and potent induction of the cellular hypoxic response, despite normoxic conditions. The hypoxic response was associated with reduced mitochondrial function but was reversible by overexpression of the mitochondrial biogenesis factor, mitochondrial transcription factor A.
   Conclusion: We conclude that IL-4 promotes intracellular ADMA accumulation, leading to mitochondrial loss through oxo-nitrative stress and hypoxic response. This provides a novel understanding of how obesity, with high ADMA levels, and asthma, with high IL-4 levels, might potentiate each other and highlights the potential of mitochondrial-targeted therapeutics in obese subjects with asthma.
C1 [Pattnaik, Bijay; Bodas, Manish; Bhatraju, Naveen Kumar; Ahmad, Tanveer; Pant, Richa; Ghosh, Balaram; Agrawal, Anurag] CSIR, Inst Genom & Integrat Biol, Immunogenet Mol Lab, Mall Rd, Delhi 110007, India.
   [Pattnaik, Bijay; Bodas, Manish; Bhatraju, Naveen Kumar; Ahmad, Tanveer; Pant, Richa; Ghosh, Balaram; Agrawal, Anurag] CSIR, Inst Genom & Integrat Biol, Ctr Excellence Translat Res Asthma & Lung Dis, Delhi, India.
   [Guleria, Randeep] All India Inst Med Sci, Dept Pulm Med & Sleep Disorders, New Delhi, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Institute of Genomics & Integrative Biology (IGIB); Council of
   Scientific & Industrial Research (CSIR) - India; CSIR - Institute of
   Genomics & Integrative Biology (IGIB); All India Institute of Medical
   Sciences (AIIMS) New Delhi
RP Agrawal, A (corresponding author), CSIR, Inst Genom & Integrat Biol, Immunogenet Mol Lab, Mall Rd, Delhi 110007, India.
EM a.agrawal@igib.in
RI Agrawal, Anurag/GZL-5821-2022; Bodas, Manish/AAE-4016-2020; Pattnaik,
   Bijay Ranjan/GOK-0878-2022
OI Bhatraju, Naveen Kumar/0000-0002-6248-7956; Pattnaik,
   Bijay/0000-0003-3534-7410; Agrawal, Anurag/0000-0002-0340-5252; Ahmad,
   Tanveer/0000-0002-8384-5273; BODAS, MANISH/0000-0002-1046-9799
FU Council of Scientific and Industrial Research (CSIR), India [MLP 5502,
   BSC 0116, MLP 1201]; Swarnajayanti Fellowship; Department of Science and
   Technology (DST), India; Department of Science and Technology,
   Government of India [GAP 0069]; Council of Scientific and Industrial
   Research, Government of India [MLP 5502, BSC 0116]
FX Supported by grants from the Council of Scientific and Industrial
   Research (CSIR), India (MLP 5502, BSC 0116, and MLP 1201); the
   Swarnajayanti Fellowship; and the Department of Science and Technology
   (DST), India. Research was supported by grant GAP 0069 (Swarnajayanti
   Project) from the Department of Science and Technology, Government of
   India, and grant MLP 5502 and BSC 0116 from the Council of Scientific
   and Industrial Research, Government of India.
CR Aggarwal S, 2014, AM J RESP CELL MOL, V50, P614, DOI 10.1165/rcmb.2013-0193OC
   Agrawal A, 2014, IMMUNOL ALLERGY CLIN, V34, P785, DOI 10.1016/j.iac.2014.07.004
   Agrawal A, 2011, AM J RESP CELL MOL, V44, P270, DOI 10.1165/rcmb.2010-0141TR
   Ahmad T, 2013, CELL DEATH DIS, V4, DOI 10.1038/cddis.2012.213
   Ahmad T, 2014, EMBO J, V33, P994, DOI 10.1002/embj.201386030
   Ahmad T, 2012, AM J RESP CELL MOL, V47, P1, DOI 10.1165/rcmb.2011-0203OC
   Ahmad T, 2010, AM J RESP CELL MOL, V42, P3, DOI 10.1165/rcmb.2009-0137RC
   Arnandis T, 2012, CELL DEATH DIFFER, V19, P1536, DOI 10.1038/cdd.2012.46
   Barnes PJ, 2008, J CLIN INVEST, V118, P3546, DOI 10.1172/JCI36130
   Böger RH, 2004, J NUTR, V134, p2842S, DOI 10.1093/jn/134.10.2842S
   Carraro S, 2013, CHEST, V144, P405, DOI 10.1378/chest.12-2379
   Chakrabarty S, 2014, MITOCHONDRION, V15, P52, DOI 10.1016/j.mito.2014.01.002
   Chua BT, 2000, J BIOL CHEM, V275, P5131, DOI 10.1074/jbc.275.7.5131
   Diaz J, 2014, IMMUNOL ALLERGY CLIN, V34, P739, DOI 10.1016/j.iac.2014.07.008
   Dillon LM, 2012, IUBMB LIFE, V64, P231, DOI 10.1002/iub.608
   duVerle DA, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019035
   Ekstrand MI, 2004, HUM MOL GENET, V13, P935, DOI 10.1093/hmg/ddh109
   Fiedler L, 2008, CELL ADHES MIGR, V2, P149, DOI 10.4161/cam.2.3.6819
   Hiramitsu M, 2014, SCI REP-UK, V4, DOI 10.1038/srep03708
   Kips JC, 2001, EUR RESPIR J, V18, p24S, DOI 10.1183/09031936.01.00229601
   Klein E, 2010, AM J PHYSIOL-LUNG C, V299, pL816, DOI 10.1152/ajplung.00188.2010
   Krishnan J, 2009, CELL METAB, V9, P512, DOI 10.1016/j.cmet.2009.05.005
   Larsson NG, 1998, NAT GENET, V18, P231, DOI 10.1038/ng0398-231
   Leishangthem Geeta Devi, 2013, ISRN Allergy, V2013, P261297, DOI 10.1155/2013/261297
   Li J, 2013, LAB INVEST, V93, P242, DOI 10.1038/labinvest.2012.164
   Liu XY, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/619207
   Mabalirajan Ulaganathan, 2013, J Allergy (Cairo), V2013, P340476, DOI 10.1155/2013/340476
   Mabalirajan U, 2010, INT IMMUNOPHARMACOL, V10, P1514, DOI 10.1016/j.intimp.2010.08.025
   Mabalirajan U, 2010, J ALLERGY CLIN IMMUN, V125, P626, DOI 10.1016/j.jaci.2009.10.065
   Movafagh S, 2015, J CELL BIOCHEM, V116, P696, DOI 10.1002/jcb.25074
   Papandreou I, 2006, CELL METAB, V3, P187, DOI 10.1016/j.cmet.2006.01.012
   Scharte M, 2006, FEBS LETT, V580, P6399, DOI 10.1016/j.febslet.2006.10.053
   Scott JA, 2014, IMMUNOL ALLERGY CLIN, V34, P767, DOI 10.1016/j.iac.2014.07.007
   Serafino-Agrusa L, 2015, WORLD J CLIN CASES, V3, P285, DOI 10.12998/wjcc.v3.i3.285
   Sharma P, 2008, IMMUNITY, V29, P551, DOI 10.1016/j.immuni.2008.07.019
   Singh VP, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0129850
   Staab EB, 2015, J IMMUNOTOXICOL, V12, P273, DOI 10.3109/1547691X.2014.961619
   Sun QZ, 2012, J IMMUNOL, V188, P3506, DOI 10.4049/jimmunol.1102635
   Takamatsu C, 2002, EMBO REP, V3, P451, DOI 10.1093/embo-reports/kvf099
   Townley RG, 2007, ANN ALLERG ASTHMA IM, V99, P215, DOI 10.1016/S1081-1206(10)60656-4
   Tran CTL, 2003, ATHEROSCLEROSIS SUPP, V4, P33, DOI 10.1016/S1567-5688(03)00032-1
   Vallance P, 2004, ARTERIOSCL THROM VAS, V24, P1023, DOI 10.1161/01.ATV.0000128897.54893.26
   Viader A, 2011, J NEUROSCI, V31, P10128, DOI 10.1523/JNEUROSCI.0884-11.2011
   Wells SM, 2007, AM J RESP CELL MOL, V36, P520, DOI 10.1165/rcmb.2006-0302SM
   Wells SM, 2009, AM J RESP CELL MOL, V40, P179, DOI 10.1165/rcmb.2008-0148OC
   Zhu LY, 2010, CELL RES, V20, P676, DOI 10.1038/cr.2010.46
NR 46
TC 32
Z9 33
U1 0
U2 15
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0091-6749
EI 1097-6825
J9 J ALLERGY CLIN IMMUN
JI J. Allergy Clin. Immunol.
PD JUL
PY 2016
VL 138
IS 1
BP 130
EP +
DI 10.1016/j.jaci.2015.11.036
PG 21
WC Allergy; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Allergy; Immunology
GA DR1IL
UT WOS:000379659100015
PM 26915676
DA 2025-06-11
ER

PT J
AU Singh, U
   Devaraj, S
   Jialal, I
   Siegel, D
AF Singh, Uma
   Devaraj, Sridevi
   Jialal, Ishwarlal
   Siegel, David
TI Comparison effect of atorvastatin (10 versus 80 mg) on biomarkers of
   inflammation and oxidative stress in subjects with metabolic syndrome
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID C-REACTIVE PROTEIN; ACUTE CORONARY SYNDROMES; MYOCARDIAL-INFARCTION;
   UNSTABLE ANGINA; ELEVATED LEVELS; ARTERY-DISEASE; ACTIVATION; STATINS;
   MATRIX-METALLOPROTEINASE-9; SIMVASTATIN
AB Metabolic syndrome (MS), characterized by low-grade inflammation, confers an increased risk for cardiovascular disease. Statins, in addition to having lipid-lowering effects, have pleiotropic effects and decrease biomarkers of inflammation and oxidative stress. The Treating to New Target Study showed a greater decrease in low-density lipoprotein (LDL) cholesterol and cardiovascular events with atorvastatin 80 mg versus 10 mg in patients with MS with coronary heart disease. However, part of this benefit could be caused by the greater pleiotropic effects of the higher dose of atorvastatin. The dose-response effect of atorvastatin on biomarkers of inflammation and oxidative stress has not been investigated in subjects with MS. Thus, the dose-response effect of atorvastatin on biomarkers of inflammation (high-sensitivity C-reactive protein [hs-CRP], matrix metalloproteinase-9, and nuclear factor-kappa B [NF-kB] activity) and oxidative stress (oxidized LDL, urinary nitrotyrosine, F2-isoprostanes, and monocyte superoxide release) was tested in a randomized double-blind clinical trial in subjects with MS. Seventy subjects were randomly assigned to receive placebo or atorvastatin 10 or 80 mg/day for 12 weeks. A strong dose-response (atorvastatin 10 compared with 80 mg, p <0.05) was observed for changes in total, LDL (32% and 44% reduction), non-high-density lipoprotein (28% and 40% reduction), and oxidized LDL cholesterol (24% and 39% reduction) at atorvastatin 10 and 80 mg, respectively. Hs-CRP, matrix metalloproteinase-9, and NF-kB significantly decreased in the 80-mg atorvastatin group compared with baseline. In conclusion, this randomized trial of subjects with MS showed the superiority of atorvastatin 80 mg compared with its 10-mg dose in decreasing oxidized LDL, hs-CRP, matrix metalloproteinase-9, and NF-kB activity. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Singh, Uma; Devaraj, Sridevi; Jialal, Ishwarlal; Siegel, David] Univ Calif Davis, Med Ctr, Dept Pathol & Lab Med, Lab Atherosclerosis & Metab Res, Sacramento, CA 95817 USA.
C3 University of California System; University of California Davis
RP Jialal, I (corresponding author), Univ Calif Davis, Med Ctr, Dept Pathol & Lab Med, Lab Atherosclerosis & Metab Res, Sacramento, CA 95817 USA.
EM ishwarlal.jialal@ucdmc.ucdavis.edu
RI Jialal, Ishwarlal/AAG-6218-2019
FU NCCIH NIH HHS [K24 AT000596, K24 AT00596] Funding Source: Medline
CR Alber HF, 2006, AM HEART J, V151, DOI 10.1016/j.ahj.2005.10.006
   Aviram M, 1998, ATHEROSCLEROSIS, V138, P271, DOI 10.1016/S0021-9150(98)00032-X
   Bierhaus A, 2001, DIABETES, V50, P2792, DOI 10.2337/diabetes.50.12.2792
   Chu CS, 2006, ACTA CARDIOL, V61, P263, DOI 10.2143/AC.61.3.2014826
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   de Winther MPJ, 2005, ARTERIOSCL THROM VAS, V25, P904, DOI 10.1161/01.ATV.0000160340.72641.87
   Deedwania P, 2006, LANCET, V368, P919, DOI 10.1016/S0140-6736(06)69292-1
   Devaraj S, 2006, J CLIN ENDOCR METAB, V91, P4489, DOI 10.1210/jc.2006-0299
   Ehara S, 2001, CIRCULATION, V103, P1955, DOI 10.1161/01.cir.103.15.1955
   Fukuda D, 2006, AM J CARDIOL, V97, P175, DOI 10.1016/j.amjcard.2005.08.020
   Ghanim H, 2004, CIRCULATION, V110, P1564, DOI 10.1161/01.CIR.0000142055.53122.FA
   Hilgendorff A, 2003, INT J CLIN PHARM TH, V41, P397
   Holvoet P, 2004, DIABETES, V53, P1068, DOI 10.2337/diabetes.53.4.1068
   Jialal I, 2001, CIRCULATION, V103, P1933
   Kinlay S, 2003, CIRCULATION, V108, P1560, DOI 10.1161/01.CIR.0000091404.09558.AF
   LIAO JK, 2003, INT J CLIN PRACT S, V135, pS51
   Liuzzo G, 2007, J AM COLL CARDIOL, V49, P185, DOI 10.1016/j.jacc.2006.07.071
   Meredith KG, 2007, AM J CARDIOL, V99, P149, DOI 10.1016/j.amjcard.2006.07.079
   Nicholls SJ, 2006, AM J CARDIOL, V97, P1553, DOI 10.1016/j.amjcard.2005.12.042
   Ozaki K, 2006, J ATHEROSCLER THROMB, V13, P216, DOI 10.5551/jat.13.216
   Penny WF, 2001, J AM COLL CARDIOL, V37, P766, DOI 10.1016/S0735-1097(00)01180-3
   Rosenson RS, 1998, JAMA-J AM MED ASSOC, V279, P1643, DOI 10.1001/jama.279.20.1643
   Shishehbor MH, 2003, CIRCULATION, V108, P426, DOI 10.1161/01.CIR.0000080895.05158.8B
   Shishehbor MH, 2003, JAMA-J AM MED ASSOC, V289, P1675, DOI 10.1001/jama.289.13.1675
   Tsimikas S, 2004, CIRCULATION, V110, P1406, DOI 10.1161/01.CIR.0000141728.23033.B5
   Verma S, 2006, CIRCULATION, V113, P2135
   Wæhre T, 2004, CIRCULATION, V109, P1966, DOI 10.1161/01.CIR.0000125700.33637.B1
   Wæhre T, 2003, J AM COLL CARDIOL, V41, P1460, DOI 10.1016/S0735-1097(03)00263-8
   Yasuda S, 2007, CLIN SCI, V112, P43, DOI 10.1042/CS20060110
   Zeng B, 2005, INTERN MED J, V35, P331, DOI 10.1111/j.1445-5994.2005.00822.x
NR 30
TC 67
Z9 76
U1 0
U2 0
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
EI 1879-1913
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD AUG 1
PY 2008
VL 102
IS 3
BP 321
EP 325
DI 10.1016/j.amjcard.2008.03.057
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 331LD
UT WOS:000258012800013
PM 18638594
OA Green Accepted
DA 2025-06-11
ER

PT S
AU Han, J
   Kaufman, RJ
AF Han, Jaeseok
   Kaufman, Randal J.
BE MacDougald, OA
TI Measurement of the Unfolded Protein Response to Investigate Its Role in
   Adipogenesis and Obesity
SO METHODS OF ADIPOSE TISSUE BIOLOGY, PT B
SE Methods in Enzymology
LA English
DT Review; Book Chapter
ID ENDOPLASMIC-RETICULUM STRESS; ER-STRESS; ADIPOSE-TISSUE;
   GENE-EXPRESSION; ATF6; PHOSPHORYLATION; PROTEOLYSIS; RESISTANCE;
   APOPTOSIS; IMPACT
AB The endoplasmic reticulum (ER) is the cellular organelle responsible for the folding of proteins destined for secretion and the intramembrane system of the cell, biosynthesis of lipids, and storage of calcium for regulated release. Extracellular stimuli and changes in intracellular homeostasis can alter the protein-folding environment of the ER and cause the accumulation of misfolded or unfolded proteins, a stress condition called ER stress. To resolve protein misfolding, cells have evolved a collection of adaptive signaling pathways, called the unfolded protein response (UPR). It is now recognized that ER stress contributes to many pathophysiological conditions. Increasing lines of evidence suggest that obesity/insulin resistance and subsequent type 2 diabetes are associated with ER stress and UPR activation in adipose tissue. However, whether and/or how ER stress and the UPR contribute to the pathogenesis of metabolic syndrome and obesity is not entirely clear. In this section, we describe how the UPR may contribute to the pathology of obesity, methods to measure UPR induction, and approaches to investigate the role of the UPR during adipocyte differentiation and in mature adipose tissue.
C1 [Han, Jaeseok; Kaufman, Randal J.] Sanford Burnham Med Res Inst, Ctr Neurosci Aging & Stem Cell Res, La Jolla, CA USA.
C3 Sanford Burnham Prebys Medical Discovery Institute
RP Kaufman, RJ (corresponding author), Sanford Burnham Med Res Inst, Ctr Neurosci Aging & Stem Cell Res, La Jolla, CA USA.
EM rkaufman@sanfordburnham.org
RI Han, Jaeseok/AAE-6872-2020; Kaufman, Randal/LGY-4753-2024
FU NHLBI NIH HHS [HL052173, HL057346] Funding Source: Medline; NIDDK NIH
   HHS [DK088227, DK042394] Funding Source: Medline
CR Back SH, 2012, ANNU REV BIOCHEM, V81, P767, DOI 10.1146/annurev-biochem-072909-095555
   Back SH, 2009, CELL METAB, V10, P13, DOI 10.1016/j.cmet.2009.06.002
   Basseri S, 2009, J LIPID RES, V50, P2486, DOI 10.1194/jlr.M900216-JLR200
   Boden G, 2008, DIABETES, V57, P2438, DOI 10.2337/db08-0604
   Calfon M, 2002, NATURE, V415, P92, DOI 10.1038/415092a
   Cao SS, 2013, GASTROENTEROLOGY, V144, P989, DOI 10.1053/j.gastro.2013.01.023
   Cencic R, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005223
   Gregor MF, 2009, DIABETES, V58, P693, DOI 10.2337/db08-1220
   Guo W, 2007, AM J PHYSIOL-ENDOC M, V293, pE576, DOI 10.1152/ajpendo.00523.2006
   Han J, 2013, DIABETOLOGIA, V56, P911, DOI 10.1007/s00125-012-2809-5
   Han J, 2013, NAT CELL BIOL, V15, P481, DOI 10.1038/ncb2738
   Harding HP, 2000, MOL CELL, V6, P1099, DOI 10.1016/S1097-2765(00)00108-8
   Harding HP, 2003, MOL CELL, V11, P619, DOI 10.1016/S1097-2765(03)00105-9
   Haze K, 1999, MOL BIOL CELL, V10, P3787, DOI 10.1091/mbc.10.11.3787
   Hosogai N, 2007, DIABETES, V56, P901, DOI 10.2337/db06-0911
   Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2548, DOI 10.1210/jc.2004-0395
   Kimball SR, 1999, INT J BIOCHEM CELL B, V31, P25, DOI 10.1016/S1357-2725(98)00128-9
   Krokowski D, 2013, J BIOL CHEM, V288, P17202, DOI 10.1074/jbc.M113.466920
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   Lu PD, 2004, EMBO J, V23, P169, DOI 10.1038/sj.emboj.7600030
   Marciniak SJ, 2004, GENE DEV, V18, P3066, DOI 10.1101/gad.1250704
   Nguyen MTA, 2005, J BIOL CHEM, V280, P35361, DOI 10.1074/jbc.M504611200
   Novoa I, 2001, J CELL BIOL, V153, P1011, DOI 10.1083/jcb.153.5.1011
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Ozean U, 2008, MOL CELL, V29, P541, DOI [10.1016/j.moicel.2007.12.023, 10.1016/j.molcel.2007.12.023]
   Scheuner D, 2001, MOL CELL, V7, P1165, DOI 10.1016/S1097-2765(01)00265-9
   Shen JS, 2002, DEV CELL, V3, P99, DOI 10.1016/S1534-5807(02)00203-4
   Shen XH, 2001, CELL, V107, P893, DOI 10.1016/S0092-8674(01)00612-2
   Szkudelski T, 2007, PHYSIOL RES, V56, P503, DOI 10.33549/physiolres.931038
   Walter P, 2011, SCIENCE, V334, P1081, DOI 10.1126/science.1209038
   Wang SY, 2012, J CELL BIOL, V197, P857, DOI 10.1083/jcb.201110131
   Wu J, 2007, DEV CELL, V13, P351, DOI 10.1016/j.devcel.2007.07.005
   Yoshida H, 2000, MOL CELL BIOL, V20, P6755, DOI 10.1128/MCB.20.18.6755-6767.2000
   Yoshida H, 2006, J CELL BIOL, V172, P565, DOI 10.1083/jcb.200508145
   Zhang KZ, 2008, NATURE, V454, P455, DOI 10.1038/nature07203
NR 36
TC 9
Z9 10
U1 0
U2 10
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0076-6879
BN 978-0-12-800280-3
J9 METHOD ENZYMOL
JI Methods Enzymol.
PY 2014
VL 538
BP 135
EP 150
DI 10.1016/B978-0-12-800280-3.00008-6
PG 16
WC Biochemical Research Methods; Biochemistry & Molecular Biology; Cell
   Biology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA BA2GT
UT WOS:000333378700008
PM 24529437
DA 2025-06-11
ER

PT J
AU Xie, ZX
   Xia, SF
   Qiao, Y
   Shi, YH
   Le, GW
AF Xie, Z. X.
   Xia, S. F.
   Qiao, Y.
   Shi, Y. H.
   Le, G. W.
TI Effect of GABA on oxidative stress in the skeletal muscles and plasma
   free amino acids in mice fed high-fat diet
SO JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
LA English
DT Article
DE metabolic syndrome; obesity; oxidative stress; protein oxidation;
   gamma-aminobutyric acid; plasma free amino acid
ID INSULIN-RESISTANCE; DIABETES-MELLITUS; NONNEURAL TISSUES; OBESITY;
   METABOLISM; TARGET; RAT; RECEPTORS; LEUCINE; HUMANS
AB Increased levels of plasma free amino acids (pFAAs) can disturb the blood glucose levels in patients with obesity, diabetes mellitus and metabolic syndrome (MS) and are associated with enhanced protein oxidation. Oxidation of proteins, especially in the muscles, can promote protein degradation and elevate the levels of pFAAs. Gamma-aminobutyric acid (GABA), a food additive, can reduce high-fat diet (HFD)-induced hyperglycaemia; however, the mechanisms remain unclear. The aim of this study was to evaluate the effects of GABA on protein oxidation and pFAAs changes. One hundred male C57BL/6 mice were randomly divided into five groups that were fed with control diet, HFD and HFD supplied with 0.2%, 0.12% and 0.06% GABA in drinking water for 20weeks respectively. HFD feeding led to muscular oxidative stress, protein oxidation, pFAA disorders, hyperglycaemia and augmented plasma GABA levels. Treatment with GABA restored normally fasting blood glucose level and dose-dependently inhibited body weight gains, muscular oxidation and protein degradation. While medium and low doses of GABA mitigated HFD-induced pFAA disorders, the high dose of GABA deteriorated the pFAA disorders. Medium dose of GABA increased the levels of GABA, but high dose of GABA reduced the levels of plasma GABA and increased the activity of succinic semialdehyde dehydrogenase in the liver. Therefore, treatment with GABA mitigated HFD-induced hyperglycaemia probably by repairing HFD-induced muscular oxidative stress and pFAA disorders in mice. Our data also suggest that an optimal dose of GABA is crucial for the prevention of excess GABA-related decrease in the levels of pFAA and GABA as well as obesity.
C1 [Xie, Z. X.; Xia, S. F.; Qiao, Y.; Shi, Y. H.; Le, G. W.] Jiangnan Univ, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, Wuxi 214122, Peoples R China.
C3 Jiangnan University
RP Le, GW (corresponding author), Jiangnan Univ, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, Wuxi 214122, Peoples R China.
EM lgw@jiangnan.edu.cn
RI SHI, YH/HLG-1159-2023
FU 12th Five-year Plan for Science and Technology Development [2012BAD
   33B05]
FX This work was supported by 12th Five-year Plan for Science and
   Technology Development (No. 2012BAD 33B05).
CR Abdou AM, 2006, BIOFACTORS, V26, P201, DOI 10.1002/biof.5520260305
   Atabek ME, 2006, EUR J PEDIATR, V165, P753, DOI 10.1007/s00431-006-0165-5
   Barry R. I., 2009, BIOCHEM J, V424, P491
   BERGSTROM J, 1974, J APPL PHYSIOL, V36, P693, DOI 10.1152/jappl.1974.36.6.693
   CHAMBLISS KL, 1995, J NEUROCHEM, V65, P851
   Clavel S, 2006, MECH AGEING DEV, V127, P794, DOI 10.1016/j.mad.2006.07.005
   Codoñer-Franch P, 2010, ACTA PAEDIATR, V99, P1841, DOI 10.1111/j.1651-2227.2010.01903.x
   FELIG P, 1970, DIABETES, V19, P727, DOI 10.2337/diab.19.10.727
   FELIG P, 1969, NEW ENGL J MED, V281, P811, DOI 10.1056/NEJM196910092811503
   Gladkevich A, 2006, AUTON NEUROSCI-BASIC, V124, P1, DOI 10.1016/j.autneu.2005.11.002
   Grimble RF, 1998, NUTRITION, V14, P605, DOI 10.1016/S0899-9007(98)80041-5
   He HJ, 2012, WORLD J DIABETES, V3, P94, DOI 10.4239/wjd.v3.i5.94
   Holguin Fernando, 2013, J Allergy (Cairo), V2013, P714595, DOI 10.1155/2013/714595
   Houten SM, 2013, HUM MOL GENET, V22, P5249, DOI 10.1093/hmg/ddt382
   Ito T, 2012, AMINO ACIDS, V42, P1529, DOI 10.1007/s00726-011-0883-5
   Kanagasabapathy G, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/185259
   Kobayashi H, 2001, J ANDROL, V22, P568
   Koopmans SJ, 2011, BMC BIOCHEM, V12, DOI 10.1186/1471-2091-12-25
   Kovacic P, 2009, OXID MED CELL LONGEV, V2, P52, DOI 10.4161/oxim.2.1.7859
   Krebs M, 2002, DIABETES, V51, P599, DOI 10.2337/diabetes.51.3.599
   LEVINE RL, 1990, METHOD ENZYMOL, V186, P464
   Li X, 2013, MOL NUTR FOOD RES, V57, P1067, DOI 10.1002/mnfr.201200311
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   Lu FF, 2012, MOL BRAIN, V5, DOI 10.1186/1756-6606-5-41
   Meaney E, 2008, CLIN EXP PHARMACOL P, V35, P895, DOI 10.1111/j.1440-1681.2008.04920.x
   Menge BA, 2010, REGUL PEPTIDES, V160, P75, DOI 10.1016/j.regpep.2009.08.001
   Mochida T, 2011, MOL GENET METAB, V103, P406, DOI 10.1016/j.ymgme.2011.05.002
   Roth F. C., 2012, NEURAL PLAST, V2012, P805
   Sailer M., 2013, PLOS ONE, V8, pe639
   She PX, 2007, AM J PHYSIOL-ENDOC M, V293, pE1552, DOI 10.1152/ajpendo.00134.2007
   Smuder AJ, 2010, FREE RADICAL BIO MED, V49, P1152, DOI 10.1016/j.freeradbiomed.2010.06.025
   Stefanovic A, 2008, DIABETES RES CLIN PR, V79, P156, DOI 10.1016/j.diabres.2007.07.019
   SZYDLOWSKA H, 1976, FOL HISTOCH CYTOCHEM, V14, P257
   Tahara A, 2013, EUR J PHARMACOL, V715, P246, DOI 10.1016/j.ejphar.2013.05.014
   Terjesen BF, 2004, J NUTR, V134, P2930, DOI 10.1093/jn/134.11.2930
   Thanapreedawat P, 2013, BIOSCI BIOTECH BIOCH, V77, P660, DOI 10.1271/bbb.120808
   Tian J, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025338
   TILLAKARATNE NJK, 1995, COMP BIOCHEM PHYS A, V112, P247, DOI 10.1016/0300-9629(95)00099-2
   Wang TJ, 2011, NAT MED, V17, P448, DOI 10.1038/nm.2307
   Wijekoon EP, 2004, CAN J PHYSIOL PHARM, V82, P506, DOI [10.1139/y04-067, 10.1139/Y04-067]
NR 40
TC 35
Z9 39
U1 2
U2 48
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0931-2439
EI 1439-0396
J9 J ANIM PHYSIOL AN N
JI J. Anim. Physiol. Anim. Nutr.
PD JUN
PY 2015
VL 99
IS 3
BP 492
EP 500
DI 10.1111/jpn.12254
PG 9
WC Agriculture, Dairy & Animal Science; Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Veterinary Sciences
GA CG5UD
UT WOS:000353360500012
PM 25266692
DA 2025-06-11
ER

PT J
AU Ehx, G
   Gérin, S
   Mathy, G
   Franck, F
   Oliveira, HC
   Vercesi, AE
   Sluse, FE
AF Ehx, Gregory
   Gerin, Stephanie
   Mathy, Gregory
   Franck, Fabrice
   Oliveira, Helena C. F.
   Vercesi, Anibal E.
   Sluse, Francis E.
TI Liver proteomic response to hypertriglyceridemia in human-apolipoprotein
   C-III transgenic mice at cellular and mitochondrial compartment levels
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
ID TRIGLYCERIDE-RICH LIPOPROTEINS; IN-GEL ELECTROPHORESIS; FERRITIN
   MESSENGER-RNA; NONALCOHOLIC STEATOHEPATITIS; OXIDATIVE STRESS; APO-CIII;
   METABOLIC SYNDROME; FATTY LIVER; IRON; TRANSPORT
AB Background: Hypertriglyceridemia (HTG) is defined as a triglyceride (TG) plasma level exceeding 150 mg/dl and is tightly associated with atherosclerosis, metabolic syndrome, obesity, diabetes and acute pancreatitis. The present study was undertaken to investigate the mitochondrial, sub-mitochondrial and cellular proteomic impact of hypertriglyceridemia in the hepatocytes of hypertriglyceridemic transgenic mice (overexpressing the human apolipoproteinC-III).
   Methods: Quantitative proteomics (2D-DIGE) analysis was carried out on both "low-expressor" (LE) and "high-expressor" (HE) mice, respectively exhibiting moderate and severe HTG, to characterize the effect of the TG plasma level on the proteomic response.
   Results: The mitoproteome analysis has revealed a large-scale phenomenon in transgenic mice, i.e. a general down-regulation of matricial proteins and up-regulation of inner membrane proteins. These data also demonstrate that the magnitude of proteomic changes strongly depends on the TG plasma level. Our different analyses indicate that, in HE mice, the capacity of several metabolic pathways is altered to promote the availability of acetyl-CoA, glycerol-3-phosphate, ATP and NADPH for TG de novo biosynthesis. The up-regulation of several cytosolic ROS detoxifying enzymes has also been observed, suggesting that the cytoplasm of HTG mice is subjected to oxidative stress. Moreover, our results suggest that iron over-accumulation takes place in the cytosol of HE mice hepatocytes and may contribute to enhance oxidative stress and to promote cellular proliferation.
   Conclusions: These results indicate that the metabolic response to HTG in human apolipoprotein C-III overexpressing mice may support a high TG production rate and that the cytosol of hepatocytes is subjected to an important oxidative stress, probably as a result of FFA over-accumulation, iron overload and enhanced activity of some ROS-producing catabolic enzymes.
C1 [Ehx, Gregory; Gerin, Stephanie; Mathy, Gregory; Franck, Fabrice; Sluse, Francis E.] Univ Liege, Dept Life Sci, Lab Bioenerget B22, B-4000 Liege, Belgium.
   [Oliveira, Helena C. F.] Univ Estadual Campinas, Inst Biol, Dept Fisiol & Biofis, BR-13083887 Campinas, SP, Brazil.
   [Vercesi, Anibal E.] Univ Estadual Campinas UNICAMP, Fac Ciencias Med, Dept Patol Clin, BR-13083 Sao Paulo, Brazil.
C3 University of Liege; Universidade Estadual de Campinas; Universidade de
   Sao Paulo; Universidade Estadual de Campinas
RP Sluse, FE (corresponding author), Univ Liege, Dept Life Sci, Lab Bioenerget B22, Blvd rectorat 27, B-4000 Liege, Belgium.
EM f.sluse@ulg.ac.be
RI Vercesi, Aníbal/C-8767-2012; Oliveira, Helena/C-1343-2013; Ehx,
   Gregory/AAH-1706-2021
OI Oliveira, Helena/0000-0003-0119-6992; Ehx, Gregory/0000-0002-7018-1770;
   Vercesi, Anibal Eugenio/0000-0001-6671-7125
FU Fond de la Recherche Fondamentale et Collective grant [FRFC 2.4597.11];
   Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [2011/50400-0]; FRS-FNRS
FX This work was supported by a Fond de la Recherche Fondamentale et
   Collective grant (FRFC 2.4597.11) and by the Fundacao de Amparo a
   Pesquisa do Estado de Sao Paulo (FAPESP) - grant #2011/50400-0. GE and
   SG are recipients of FRS-FNRS doctoral fellowships. FF is a Research
   Director of the FRS-FNRS. We would like to thank Dr. Luciane Alberici
   for providing us with biological samples and Dr. Pierre Leprince and
   Prof. Edwin de Pauw for providing us with access to proteomic and mass
   spectrometry platforms.
CR AALTOSETALA K, 1992, J CLIN INVEST, V90, P1889, DOI 10.1172/JCI116066
   Alberici LC, 2003, J BIOENERG BIOMEMBR, V35, P451, DOI 10.1023/A:1027343915452
   Alberici LC, 2006, GASTROENTEROLOGY, V131, P1228, DOI 10.1053/j.gastro.2006.07.021
   Alberici LC, 2011, J BIOENERG BIOMEMBR, V43, P19, DOI 10.1007/s10863-011-9326-y
   Alberici LC, 2009, FREE RADICAL BIO MED, V47, P1432, DOI 10.1016/j.freeradbiomed.2009.08.013
   Amaral MEC, 2002, HORM METAB RES, V34, P21, DOI 10.1055/s-2002-19962
   Bonnard C, 2008, J CLIN INVEST, V118, P789, DOI 10.1172/JCI32601
   Caldwell SH, 2009, HEPATOLOGY, V49, P1888, DOI 10.1002/hep.22851
   Callister SJ, 2006, J PROTEOME RES, V5, P277, DOI 10.1021/pr050300l
   Cardoso AR, 2010, BBA-BIOENERGETICS, V1797, P832, DOI 10.1016/j.bbabio.2009.12.017
   Dansen TB, 2001, IUBMB LIFE, V51, P223
   Dongiovanni P, 2011, J HEPATOL, V55, P920, DOI 10.1016/j.jhep.2011.05.008
   Douette P, 2005, J PROTEOME RES, V4, P2024, DOI 10.1021/pr050187z
   Fodor IK, 2005, BIOINFORMATICS, V21, P3733, DOI 10.1093/bioinformatics/bti612
   Garlid KD, 2003, BBA-BIOENERGETICS, V1606, P23, DOI 10.1016/S0005-2728(03)00108-7
   GINSBERG HN, 1986, J CLIN INVEST, V78, P1287, DOI 10.1172/JCI112713
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Hayes JD, 2005, ANNU REV PHARMACOL, V45, P51, DOI 10.1146/annurev.pharmtox.45.120403.095857
   Haynes CM, 2013, TRENDS CELL BIOL, V23, P311, DOI 10.1016/j.tcb.2013.02.002
   HENTZE MW, 1987, SCIENCE, V238, P1570, DOI 10.1126/science.3685996
   HURKMAN WJ, 1986, PLANT PHYSIOL, V81, P802, DOI 10.1104/pp.81.3.802
   ITO Y, 1990, SCIENCE, V249, P790, DOI 10.1126/science.2167514
   Jong MC, 2001, J LIPID RES, V42, P1578
   Knowles MR, 2003, PROTEOMICS, V3, P1162, DOI 10.1002/pmic.200300437
   Koek GH, 2011, CLIN CHIM ACTA, V412, P1297, DOI 10.1016/j.cca.2011.04.013
   Krawczyk M, 2010, BEST PRACT RES CL GA, V24, P695, DOI 10.1016/j.bpg.2010.08.005
   Leclercq IA, 2000, J CLIN INVEST, V105, P1067, DOI 10.1172/JCI8814
   Lee HY, 2011, HEPATOLOGY, V54, P1650, DOI 10.1002/hep.24571
   Li Lei O, 2010, Mol Endocrinol, V24, P657, DOI 10.1210/me.2009-0152
   MacGarvey NC, 2012, AM J RESP CRIT CARE, V185, P851, DOI 10.1164/rccm.201106-1152OC
   Mackenzie EL, 2008, ANTIOXID REDOX SIGN, V10, P997, DOI 10.1089/ars.2007.1893
   MAEDA N, 1994, J BIOL CHEM, V269, P23610
   Mann CJ, 1997, J BIOL CHEM, V272, P31348, DOI 10.1074/jbc.272.50.31348
   Marouga R, 2005, ANAL BIOANAL CHEM, V382, P669, DOI 10.1007/s00216-005-3126-3
   Mathy G, 2006, J PROTEOME RES, V5, P339, DOI 10.1021/pr050346e
   Mathy G, 2008, BBA-BIOENERGETICS, V1777, P1072, DOI 10.1016/j.bbabio.2008.04.042
   Ng DS, 2004, J BIOL CHEM, V279, P7636, DOI 10.1074/jbc.M309439200
   Petrak J, 2007, AM J PHYSIOL-GASTR L, V292, pG1490, DOI 10.1152/ajpgi.00455.2006
   Piao CS, 2010, PHARMACOL RES, V61, P342, DOI 10.1016/j.phrs.2009.11.009
   Räisänen SR, 1999, FASEB J, V13, P513, DOI 10.1096/fasebj.13.3.513
   Ray PD, 2012, CELL SIGNAL, V24, P981, DOI 10.1016/j.cellsig.2012.01.008
   REAVEN GM, 1994, J LIPID RES, V35, P820
   Reid AE, 2001, GASTROENTEROLOGY, V121, P710, DOI 10.1053/gast.2001.27126
   Rhee SG, 2005, FREE RADICAL BIO MED, V38, P1543, DOI 10.1016/j.freeradbiomed.2005.02.026
   ROUAULT TA, 1988, SCIENCE, V241, P1207, DOI 10.1126/science.3413484
   Salerno AG, 2007, INT J OBESITY, V31, P1586, DOI 10.1038/sj.ijo.0803646
   Shevchenko A, 1996, BIOCHEM SOC T, V24, P893, DOI 10.1042/bst0240893
   SHOULDERS CC, 1991, ATHEROSCLEROSIS, V87, P239, DOI 10.1016/0021-9150(91)90026-Y
   Sickmann A, 2003, P NATL ACAD SCI USA, V100, P13207, DOI 10.1073/pnas.2135385100
   SOTTOCASA GL, 1967, J CELL BIOL, V32, P415, DOI 10.1083/jcb.32.2.415
   Thomas A, 2012, PROTEOMICS, V12, P1437, DOI 10.1002/pmic.201100628
   TOSKES PP, 1990, GASTROENTEROL CLIN N, V19, P783
   WANG CS, 1985, J CLIN INVEST, V75, P384, DOI 10.1172/JCI111711
   WINDLER E, 1985, J LIPID RES, V26, P556
   Zhang YKJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059122
   Zheng J, 2011, BMC CANCER, V11, DOI 10.1186/1471-2407-11-251
NR 56
TC 8
Z9 9
U1 2
U2 6
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD JUL 21
PY 2014
VL 13
AR 116
DI 10.1186/1476-511X-13-116
PG 16
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA AM0DF
UT WOS:000339512800001
PM 25047818
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pajer, KA
AF Pajer, Kathleen A.
TI Cardiovascular disease risk factors in adolescents: do negative emotions
   and hypothalamic-pituitary-adrenal axis function play a role?
SO CURRENT OPINION IN PEDIATRICS
LA English
DT Review
DE adolescents; cardiovascular disease risk; depression; hostility/anger;
   hypothalamic-pituitary-adrenal axis
ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; SALIVARY CORTISOL;
   DEPRESSIVE SYMPTOMS; CONDUCT DISORDER; ARTERY-DISEASE; METABOLIC
   SYNDROME; MAJOR DEPRESSION; HYPERCORTISOLEMIC DEPRESSION;
   PROINFLAMMATORY CYTOKINES
AB Purpose of review Negative emotions such as depression and hostility/anger are important risk factors for cardiovascular disease in adults, but are often neglected in treatment or prevention programs. Adolescence is a stage of life when negative emotions often first become problematic and is also a time when the pathogenesis of cardiovascular disease appears I to accelerate. The literature on negative emotions and cardiovascular disease risk factors in adolescents is reviewed here.
   Recent findings Research indicates that negative emotions are associated with cardiovascular disease risk factors in adolescence. Negative emotions are also associated with several types of hypothalamic-pituitary-adrenal axis dysregulation. Such dysregulation appears to have a facilitatory effect on cardiovascular disease development and progression in adults. Thus, it is possible that negative emotions in adolescents may be risk factors for the development of cardiovascular disease via dysiregulation of the hypothalamic-pituitary-adrenal axis. Although this hypothesis has not been directly tested, some studies indirectly support the hypothesis.
   Summary Negative emotions are associated with cardiovascular disease risk factors in adolescents; it is possible that hypothalamic-pituitary-adrenal axis dysiregulation is an important mechanism. This hypothesis merits further research, If the hypothesis is valid, it has significant implications for early prevention of cardiovascular disease.
C1 Ohio State Univ, Coll Med, Columbus Childrens Res Inst, Dept Pediat, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University
RP Pajer, KA (corresponding author), Ohio State Univ, Coll Med, Columbus Childrens Res Inst, Dept Pediat, Timken Hall G354,700 Childrens Dr, Columbus, OH 43205 USA.
EM pajerk@pediatrics.ohio-state.edu
FU NIMH NIH HHS [R01 MH 066003] Funding Source: Medline
CR Adam EK, 2006, PSYCHONEUROENDOCRINO, V31, P664, DOI 10.1016/j.psyneuen.2006.01.010
   Alesci S, 2005, J CLIN ENDOCR METAB, V90, P2522, DOI 10.1210/jc.2004-1667
   Anderson DA, 2002, APPETITE, V38, P13, DOI 10.1006/appe.2001.0459
   [Anonymous], 2000, J ALLERGY CLIN IMMUN
   Beaglehole R, 2002, INT J EPIDEMIOL, V31, P1117, DOI 10.1093/ije/31.6.1117
   BERENSON GS, 1992, AM J CARDIOL, V70, P851, DOI 10.1016/0002-9149(92)90726-F
   Björntorp P, 2000, NUTRITION, V16, P924, DOI 10.1016/S0899-9007(00)00422-6
   Black PH, 2002, J PSYCHOSOM RES, V52, P1, DOI 10.1016/S0022-3999(01)00302-6
   Broadley AJM, 2002, HEART, V88, P521, DOI 10.1136/heart.88.5.521
   Bunde J, 2006, HEALTH PSYCHOL, V25, P493, DOI 10.1037/0278-6133.25.4.493
   Calcagni E, 2006, ANN NY ACAD SCI, V1069, P62, DOI 10.1196/annals.1351.006
   Chrapko WE, 2004, BIOL PSYCHIAT, V56, P129, DOI 10.1016/j.biopsych.2004.03.003
   CHROUSOS GP, 1992, JAMA-J AM MED ASSOC, V267, P1244, DOI 10.1001/jama.267.9.1244
   Cyranowski JM, 2007, BRAIN BEHAV IMMUN, V21, P229, DOI 10.1016/j.bbi.2006.07.005
   Dahl R E, 2001, CNS Spectr, V6, P60
   Danner M, 2003, PSYCHOSOM MED, V65, P347, DOI 10.1097/01.PSY.0000041542.29808.01
   De Genna NM, 2006, J DEV BEHAV PEDIATR, V27, P297, DOI 10.1097/00004703-200608000-00004
   Dorn LD, 1996, J AM ACAD CHILD PSY, V35, P764, DOI 10.1097/00004583-199606000-00016
   Duclos M, 2005, J NEUROENDOCRINOL, V17, P740, DOI 10.1111/j.1365-2826.2005.01367.x
   FEMANDER AF, 2006, ETHNIC DIS, V16, P41
   Flinn MV, 1997, AM J PHYS ANTHROPOL, V102, P33
   Ford DE, 2004, ARCH INTERN MED, V164, P1010, DOI 10.1001/archinte.164.9.1010
   Goodyer IM, 2003, PSYCHOL MED, V33, P601, DOI 10.1017/S0033291702007286
   Goodyer IM, 1996, PSYCHOL MED, V26, P245, DOI 10.1017/S0033291700034644
   Gordis EB, 2006, PSYCHONEUROENDOCRINO, V31, P976, DOI 10.1016/j.psyneuen.2006.05.010
   Gottdiener JS, 2003, AM J CARDIOL, V92, P687, DOI 10.1016/S0002-9149(03)00823-3
   Groner JA, 2006, PEDIATRICS, V118, P1683, DOI 10.1542/peds.2005-2992
   Grunbaum JA, 1997, ANN BEHAV MED, V19, P179, DOI 10.1007/BF02883335
   Gump BB, 1999, HEALTH PSYCHOL, V18, P140, DOI 10.1037/0278-6133.18.2.140
   Hasler G, 2005, MOL PSYCHIATR, V10, P842, DOI 10.1038/sj.mp.4001671
   Kop WJ, 1999, PSYCHOSOM MED, V61, P476, DOI 10.1097/00006842-199907000-00012
   Kop WJ, 2002, AM J CARDIOL, V89, P419, DOI 10.1016/S0002-9149(01)02264-0
   Kubzansky LD, 2005, PSYCHOSOM MED, V67, pS10, DOI 10.1097/01.psy.0000164012.88829.41
   KUROU I, 2006, ANN NY ACAD SCI, V1083, P77
   Lett HS, 2004, PSYCHOSOM MED, V66, P305, DOI 10.1097/01.psy.0000126207.43307.c0
   Loney BR, 2006, J CHILD PSYCHOL PSYC, V47, P30, DOI 10.1111/j.1469-7610.2005.01444.x
   Luby JL, 2003, ARCH GEN PSYCHIAT, V60, P1248, DOI 10.1001/archpsyc.60.12.1248
   Matthews KA, 2005, AM PSYCHOL, V60, P783, DOI 10.1037/0003-066X.60.8.783
   MATTHEWS KA, 1977, J CHRON DIS, V30, P489, DOI 10.1016/0021-9681(77)90071-6
   Matthews K, 2006, PSYCHOSOM MED, V68, P657, DOI 10.1097/01.psy.0000244071.42939.0e
   Matthews KA, 2007, PSYCHOSOM MED, V69, P124, DOI 10.1097/01.psy.0000256574.30389.1b
   McBurnett K, 2000, ARCH GEN PSYCHIAT, V57, P38, DOI 10.1001/archpsyc.57.1.38
   MCBURNETT K, 1991, J AM ACAD CHILD PSY, V30, P192, DOI 10.1097/00004583-199103000-00005
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   McGill HC, 2000, AM J CLIN NUTR, V72, p1307S, DOI 10.1093/ajcn/72.5.1307s
   Miller TQ, 1996, PSYCHOL BULL, V119, P322, DOI 10.1037/0033-2909.119.2.322
   MOSS HB, 1995, BIOL PSYCHIAT, V38, P547, DOI 10.1016/0006-3223(94)00382-D
   Mustillo S, 2003, PEDIATRICS, V111, P851, DOI 10.1542/peds.111.4.851
   Oosterlaan J, 2005, PSYCHIAT RES, V134, P1, DOI 10.1016/j.psychres.2004.12.005
   Pajer K, 2002, BRAIN BEHAV IMMUN, V16, P747, DOI 10.1016/S0889-1591(02)00027-2
   Pajer K, 2001, J CHILD ADOLES SUBST, V10, P65, DOI 10.1300/J029v10n04_07
   Pajer K, 2001, ARCH GEN PSYCHIAT, V58, P297, DOI 10.1001/archpsyc.58.3.297
   Pajer K, 2006, PSYCHONEUROENDOCRINO, V31, P1245, DOI 10.1016/j.psyneuen.2006.09.005
   Panagiotakos DB, 2004, EUR HEART J, V25, P492, DOI 10.1016/j.ehj.2004.01.018
   Pine DS, 1996, PSYCHOSOM MED, V58, P342, DOI 10.1097/00006842-199607000-00007
   Pine DS, 1997, AM J PUBLIC HEALTH, V87, P1303, DOI 10.2105/AJPH.87.8.1303
   Pollitt RA, 2005, J BEHAV MED, V28, P53, DOI 10.1007/s10865-005-2563-y
   Räikkönen K, 2003, HEALTH PSYCHOL, V22, P279, DOI 10.1037/0278-6133.22.3.279
   Ravaja N, 1996, HEALTH PSYCHOL, V15, P18, DOI 10.1037/0278-6133.15.1.18
   Richardson LP, 2006, GEN HOSP PSYCHIAT, V28, P313, DOI 10.1016/j.genhosppsych.2006.03.007
   Rosmond R, 2000, J INTERN MED, V247, P188, DOI 10.1046/j.1365-2796.2000.00603.x
   Roy MP, 2001, PSYCHONEUROENDOCRINO, V26, P375, DOI 10.1016/S0306-4530(00)00061-5
   Rozanski A, 2005, J AM COLL CARDIOL, V45, P637, DOI 10.1016/j.jacc.2004.12.005
   Rozanski A, 1999, CIRCULATION, V99, P2192, DOI 10.1161/01.CIR.99.16.2192
   Rugulies R, 2002, AM J PREV MED, V23, P51, DOI 10.1016/S0749-3797(02)00439-7
   Rybakowski JK, 2006, BIOL PSYCHIAT, V60, P889, DOI 10.1016/j.biopsych.2006.03.025
   Sapolsky RM, 2000, ENDOCR REV, V21, P55, DOI 10.1210/er.21.1.55
   Suarez EC, 2004, PSYCHOSOM MED, V66, P684, DOI 10.1097/01.psy.0000138281.73634.67
   Suarez EC, 2003, PSYCHOSOM MED, V65, P362, DOI 10.1097/01.PSY.0000035719.79068.2B
   Suarez EC, 2002, BRAIN BEHAV IMMUN, V16, P675, DOI 10.1016/S0889-1591(02)00019-3
   Suls J, 2005, PSYCHOL BULL, V131, P260, DOI 10.1037/0033-2909.131.2.260
   Sutton-Tyrrell K, 2005, CIRCULATION, V111, P1242, DOI 10.1161/01.CIR.0000157697.54255.CE
   Tanofsky-Kraff M, 2006, PEDIATRICS, V117, P1203, DOI 10.1542/peds.2005-1329
   TENNES K, 1985, PSYCHOSOM MED, V47, P451, DOI 10.1097/00006842-198509000-00005
   TENNES K, 1986, J AM ACAD CHILD PSY, V25, P764, DOI 10.1016/S0002-7138(09)60193-X
   Thom T, 2006, CIRCULATION, V113, pE85, DOI 10.1161/CIRCULATIONAHA.105.171600
   van Goozen SHM, 1998, BIOL PSYCHIAT, V43, P531, DOI 10.1016/S0006-3223(97)00253-9
   VANYUKOV MM, 1993, PSYCHIAT RES, V46, P9, DOI 10.1016/0165-1781(93)90003-Y
   Vogelzangs N, 2007, PSYCHONEUROENDOCRINO, V32, P151, DOI 10.1016/j.psyneuen.2006.11.009
   Waller MW, 2006, ARCH WOMEN MENT HLTH, V9, P139, DOI 10.1007/s00737-006-0121-4
   Weber-Hamann B, 2002, PSYCHOSOM MED, V64, P274, DOI 10.1097/00006842-200203000-00010
   WOODMAN DD, 1978, J PSYCHOSOM RES, V22, P133, DOI 10.1016/0022-3999(78)90040-5
NR 82
TC 6
Z9 6
U1 1
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1040-8703
J9 CURR OPIN PEDIATR
JI CURR. OPIN. PEDIATR.
PD OCT
PY 2007
VL 19
IS 5
BP 559
EP 564
DI 10.1097/MOP.0b013e3282ef443a
PG 6
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA 217HG
UT WOS:000249938400006
PM 17885475
DA 2025-06-11
ER

PT J
AU Hurtado-Roca, Y
   Bueno, H
   Fernandez-Ortiz, A
   Ordovas, JM
   Ibañez, B
   Fuster, V
   Rodriguez-Artalejo, F
   Laclaustra, M
AF Hurtado-Roca, Yamilee
   Bueno, Hector
   Fernandez-Ortiz, Antonio
   Maria Ordovas, Jose
   Ibanez, Borja
   Fuster, Valentin
   Rodriguez-Artalejo, Fernando
   Laclaustra, Martin
TI Oxidized LDL Is Associated With Metabolic Syndrome Traits Independently
   of Central Obesity and Insulin Resistance
SO DIABETES
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; ACTIVATED SIGNALING PATHWAYS; OXIDATIVE STRESS
   MARKERS; SUBCLINICAL ATHEROSCLEROSIS; CARDIOVASCULAR-DISEASE;
   ANTIOXIDANT ENZYMES; PLASMA-GLUCOSE; RISK; MECHANISMS; BIOMARKERS
AB This study assesses whether oxidative stress, using oxidized LDL (ox-LDL) as a proxy, is associated with metabolic syndrome (MS), whether ox-LDL mediates the association between central obesity and MS, and whether insulin resistance mediates the association between ox-LDL and MS. We examined baseline data from 3,987 subjects without diabetes in the Progression of Early Subclinical Atherosclerosis (PESA) Study. For the second, third, and fourth ox-LDL quartiles versus the first, the odds ratios (95% CI) for MS were 0.84 (0.52, 1.36), 1.47 (0.95, 2.32), and 2.57 (1.66, 4.04) (P < 0.001 for trend) once adjusted for age, sex, smoking, LDL-cholesterol, BMI, waist circumference, and HOMA-insulin resistance (HOMA-IR). Results showing the same trend were found for all MS components except glucose concentration. Ox-LDL mediated 13.9% of the association of waist circumference with triglycerides and only 1-3% of the association with HDL-cholesterol, blood pressure, and insulin concentration. HOMA-IR did not mediate the association between ox-LDL and MS components. This study found higher ox-LDL concentrations were associated with MS and its components independently of central obesity and insulin resistance. Ox-LDL may reflect core mechanisms through which MS components develop and progress in parallel with insulin resistance and could be a clinically relevant predictor of MS development.
C1 [Hurtado-Roca, Yamilee; Bueno, Hector; Fernandez-Ortiz, Antonio; Maria Ordovas, Jose; Ibanez, Borja; Fuster, Valentin; Laclaustra, Martin] Ctr Nacl Invest Cardiovasc Carlos III, Madrid, Spain.
   [Hurtado-Roca, Yamilee; Rodriguez-Artalejo, Fernando; Laclaustra, Martin] Univ Autonoma Madrid Idipaz, Ctr Invest Biomed Red Epidemiol & Salud Publ, Madrid, Spain.
   [Hurtado-Roca, Yamilee; Rodriguez-Artalejo, Fernando; Laclaustra, Martin] Univ Autonoma Madrid Idipaz, Sch Med, Dept Prevent Med & Publ Hlth, Madrid, Spain.
   [Hurtado-Roca, Yamilee] Boca Raton Clin Res Global Peru, Lima, Peru.
   [Bueno, Hector] Hosp 12 Octubre, Madrid, Spain.
   [Fernandez-Ortiz, Antonio] Univ Complutense, Hosp Clin San Carlos, Madrid, Spain.
   [Maria Ordovas, Jose] Tufts Univ, USDA, Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
   [Ibanez, Borja] Univ Autonoma Madrid, Inst Invest, Fdn Jimenez Diaz Hosp, Madrid, Spain.
   [Fuster, Valentin] Icahn Sch Med Mt Sinai, New York, NY 10029 USA.
   [Laclaustra, Martin] St Louis Univ, Dept Epidemiol, St Louis, MO 63103 USA.
C3 Centro Nacional de Investigaciones Cardiovasculares (CNIC); CIBER -
   Centro de Investigacion Biomedica en Red; CIBERESP; Hospital
   Universitario 12 de Octubre; Hospital Clinico San Carlos; Complutense
   University of Madrid; United States Department of Agriculture (USDA);
   Tufts University; Autonomous University of Madrid; Icahn School of
   Medicine at Mount Sinai; Saint Louis University
RP Laclaustra, M (corresponding author), Ctr Nacl Invest Cardiovasc Carlos III, Madrid, Spain.; Laclaustra, M (corresponding author), Univ Autonoma Madrid Idipaz, Ctr Invest Biomed Red Epidemiol & Salud Publ, Madrid, Spain.; Laclaustra, M (corresponding author), Univ Autonoma Madrid Idipaz, Sch Med, Dept Prevent Med & Publ Hlth, Madrid, Spain.; Laclaustra, M (corresponding author), St Louis Univ, Dept Epidemiol, St Louis, MO 63103 USA.
EM martin.laclaustra@uam.es
RI Fuster, Valentin/H-4319-2015; Laclaustra, Martin/C-6709-2015;
   Fernandez-Ortiz, Antonio/B-2227-2017; Ibanez, Borja/J-6993-2014; BUENO,
   HECTOR/I-3910-2015
OI Fuster, Valentin/0000-0002-9043-9986; Laclaustra,
   Martin/0000-0003-3963-0846; HURTADO-ROCA, YAMILEE/0000-0003-1993-6223;
   Fernandez-Ortiz, Antonio/0000-0002-3239-1910; Ibanez,
   Borja/0000-0002-5036-254X; BUENO, HECTOR/0000-0003-0277-7596
FU Republic of Peru and the Inter-American Development Bank through FINCyT
   Science and Technology Program Scholarships [088-FINCyT-BDE-2014,
   1663/OC-PE]; Institute de Salud Carlos III; European Regional
   Development Fund/European Social Fund, "Investing in Your Future"
   [PI10/00021, PI14/00009]; CNIC and Santander Bank; Spanish Ministry of
   Economy and Competitiveness (MINECO); Pro-CNIC Foundation and is a
   Severo Ochoa Center of Excellence (MINECO) [SEV-2015-0505]
FX Y.H.-R. received support from Republic of Peru and the Inter-American
   Development Bank through FINCyT Science and Technology Program
   Scholarships No. 088-FINCyT-BDE-2014 under agreement 1663/OC-PE. M.L.
   received partial support from the Institute de Salud Carlos III,
   cofunded by the European Regional Development Fund/European Social Fund,
   "Investing in Your Future" grants PI10/00021 and PI14/00009. The PESA
   study is supported by a noncompetitive unrestricted grant shared between
   the CNIC and Santander Bank. The CNIC is supported by the Spanish
   Ministry of Economy and Competitiveness (MINECO) and the Pro-CNIC
   Foundation and is a Severo Ochoa Center of Excellence (MINECO award
   SEV-2015-0505).
CR Abdilla N, 2007, J HUM HYPERTENS, V21, P68, DOI 10.1038/sj.jhh.1002105
   Abramov AY, 2007, J NEUROSCI, V27, P1129, DOI 10.1523/JNEUROSCI.4468-06.2007
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   [Anonymous], 2015, OB OV
   Ascaso JF, 2003, DIABETES CARE, V26, P3320, DOI 10.2337/diacare.26.12.3320
   Barbosa KBF, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-61
   Berneis KK, 2002, J LIPID RES, V43, P1363, DOI 10.1194/jlr.R200004-JLR200
   Boyer F, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/534873
   Castro JP, 2016, BIOL CHEM
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Ceriello A, 1996, DIABETES, V45, P471, DOI 10.2337/diabetes.45.4.471
   Chandel NS, 2000, J BIOL CHEM, V275, P25130, DOI 10.1074/jbc.M001914200
   Chen NG, 2000, ATHEROSCLEROSIS, V152, P203, DOI 10.1016/S0021-9150(99)00460-8
   Dalle-Donne I, 2006, CLIN CHEM, V52, P601, DOI 10.1373/clinchem.2005.061408
   Dugan LL, 1999, FREE RADICALS HYPOXI
   El Assaad MA, 2002, BLOOD PRESS MONIT, V7, P237, DOI 10.1097/00126097-200208000-00006
   Evans JL, 2003, DIABETES, V52, P1, DOI 10.2337/diabetes.52.1.1
   Evans JL, 2002, ENDOCR REV, V23, P599, DOI 10.1210/er.2001-0039
   Evans JL, 2005, ANTIOXID REDOX SIGN, V7, P1040, DOI 10.1089/ars.2005.7.1040
   Fernández-Friera L, 2015, CIRCULATION, V131, P2104, DOI 10.1161/CIRCULATIONAHA.114.014310
   Fernández-Ortiz A, 2013, AM HEART J, V166, P990, DOI 10.1016/j.ahj.2013.08.024
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
   Holvoet P, 2006, AM J CLIN NUTR, V83, P1438, DOI 10.1093/ajcn/83.6.1438
   Holvoet P, 2004, DIABETES, V53, P1068, DOI 10.2337/diabetes.53.4.1068
   Holvoet P, 2008, JAMA-J AM MED ASSOC, V299, P2287, DOI 10.1001/jama.299.19.2287
   Husain Kazim, 2015, World J Biol Chem, V6, P209, DOI 10.4331/wjbc.v6.i3.209
   Kawada T, 2012, INT J CARDIOL, V157, P119, DOI 10.1016/j.ijcard.2012.03.107
   KAWAMURA M, 1994, J CLIN INVEST, V94, P771, DOI 10.1172/JCI117396
   Kotani K, 2009, ATHEROSCLEROSIS, V204, P526, DOI 10.1016/j.atherosclerosis.2008.09.017
   Lapointe A, 2007, ATHEROSCLEROSIS, V191, P362, DOI 10.1016/j.atherosclerosis.2006.03.036
   Liguori A, 2001, EUR HEART J, V22, P2075, DOI 10.1053/euhj.2001.2655
   Linna MS, 2015, ANN MED, V47, P394, DOI 10.3109/07853890.2015.1043939
   Maiolino G, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/714653
   Manna P, 2015, METAB SYNDR RELAT D, V13, P423, DOI 10.1089/met.2015.0095
   Matsuda M, 2013, OBES RES CLIN PRACT, V7, pE330, DOI 10.1016/j.orcp.2013.05.004
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Matusik P, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/315747
   Netzer N, 2015, BIOMOLECULES, V5, P1143, DOI 10.3390/biom5021143
   Njajou OT, 2009, DIABETES-METAB RES, V25, P733, DOI 10.1002/dmrr.1011
   Ordovas JM, 2008, KIDNEY INT, V74, pS10, DOI 10.1038/ki.2008.517
   R Core Team, 2013, LANG ENV STAT COMP
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   Roberts CK, 2006, METABOLISM, V55, P928, DOI 10.1016/j.metabol.2006.02.022
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Solaini G, 2010, BBA-BIOENERGETICS, V1797, P1171, DOI 10.1016/j.bbabio.2010.02.011
   Srikanthan K, 2016, INT J MED SCI, V13, P25, DOI 10.7150/ijms.13800
   Tangvarasittichai S, 2015, WORLD J DIABETES, V6, P456, DOI 10.4239/wjd.v6.i3.456
   Tingley D, 2014, J STAT SOFTW, V59
   Trpkovic A, 2015, CRIT REV CL LAB SCI, V52, P70, DOI 10.3109/10408363.2014.992063
   Ueba T, 2009, ATHEROSCLEROSIS, V203, P243, DOI 10.1016/j.atherosclerosis.2008.05.048
   Vincent HK, 2006, INT J OBESITY, V30, P400, DOI 10.1038/sj.ijo.0803177
   Weinbrenner T, 2006, AM J CLIN NUTR, V83, P30
NR 53
TC 43
Z9 45
U1 0
U2 19
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD FEB
PY 2017
VL 66
IS 2
BP 474
EP 482
DI 10.2337/db16-0933
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EI7PS
UT WOS:000392691000024
PM 27993926
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Tamura, Y
   Omura, T
   Toyoshima, K
   Araki, A
AF Tamura, Yoshiaki
   Omura, Takuya
   Toyoshima, Kenji
   Araki, Atsushi
TI Nutrition Management in Older Adults with Diabetes: A Review on the
   Importance of Shifting Prevention Strategies from Metabolic Syndrome to
   Frailty
SO NUTRIENTS
LA English
DT Review
DE diabetes mellitus; nutrition management; elderly; frailty; cognitive
   impairment
ID MILD COGNITIVE IMPAIRMENT; VITAMIN-D SUPPLEMENTATION; JAPANESE
   ELDERLY-PATIENTS; BONE-MINERAL DENSITY; BODY-MASS INDEX;
   QUALITY-OF-LIFE; SARCOPENIC OBESITY; CARDIOVASCULAR-DISEASE; OXIDATIVE
   STRESS; MUSCLE MASS
AB The increasing prevalence of older adults with diabetes has become a major social burden. Diabetes, frailty, and cognitive dysfunction are closely related to the mechanisms of aging. Insulin resistance, arteriosclerosis, chronic inflammation, oxidative stress, and mitochondrial dysfunction may be common mechanisms shared by frailty and cognitive impairment. Hyperglycemia, hypoglycemia, obesity, vascular factors, physical inactivity, and malnutrition are important risk factors for cognitive impairment and frailty in older adults with diabetes. The impact of nutrients on health outcomes varies with age; thus, shifting diet therapy strategies from the treatment of obesity/metabolic syndrome to frailty prevention may be necessary in patients with diabetes who are over 75 years of age, have frailty or sarcopenia, and experience malnutrition. For the prevention of frailty, optimal energy intake, sufficient protein and vitamin intake, and healthy dietary patterns should be recommended. The treatment of diabetes after middle age should include the awareness of proper glycemic control aimed at extending healthy life expectancy with proper nutrition, exercise, and social connectivity. Nutritional therapy in combination with exercise, optimal glycemic and metabolic control, and social participation/support for frailty prevention can extend healthy life expectancy and maintain quality of life in older adults with diabetes mellitus.
C1 [Tamura, Yoshiaki; Omura, Takuya; Toyoshima, Kenji; Araki, Atsushi] Tokyo Metropolitan Geriatr Hosp, Dept Diabet Metab & Endocrinol, Itabashi Ku, 35-2 Sakae Cho, Tokyo 1730015, Japan.
C3 Tokyo Metropolitan Institute of Gerontology
RP Araki, A (corresponding author), Tokyo Metropolitan Geriatr Hosp, Dept Diabet Metab & Endocrinol, Itabashi Ku, 35-2 Sakae Cho, Tokyo 1730015, Japan.
EM tamurayo@tmghig.jp; takuya_omura@tmghig.jp; kenji_toyoshima@tmghig.jp;
   aaraki@tmghig.jp
RI Omura, Takuya/X-4839-2019; Araki, Atsushi/JVE-0081-2024
OI Omura, Takuya/0000-0001-5490-8653; Araki, Atsushi/0000-0001-9088-2841;
   toyoshima, kenji/0000-0002-1220-273X
FU National Center for Geriatrics and Gerontology [30-1, 28-30];
   Grants-in-Aid for Scientific Research [20K19737] Funding Source: KAKEN
FX This study was supported by a grant from the Research Funding for
   Longevity Sciences (28-30, 30-1) from the National Center for Geriatrics
   and Gerontology.
CR Abbatecola AM, 2006, NEUROLOGY, V67, P235, DOI 10.1212/01.wnl.0000224760.22802.e8
   Abdelhafiz AH, 2015, AGING DIS, V6, P156, DOI 10.14336/AD.2014.0330
   Alfonso-Rosa RM, 2013, J NUTR HEALTH AGING, V17, P315, DOI 10.1007/s12603-013-0028-5
   [Anonymous], 2017, J Diabetes Investig, V8, P126, DOI 10.1111/jdi.12599
   [Anonymous], 2019, Pensions at a Glance 2019, DOI DOI 10.1787/B6D3DCFC-EN
   [Anonymous], 2020, NAT NUTR HLTH SURV 2
   [Anonymous], MAN OLD PROPL TYP 2
   Arai H, 2020, GERIATR GERONTOL INT, V20, P14, DOI 10.1111/ggi.13831
   Araki A, 2017, GERIATR GERONTOL INT, V17, P1168, DOI 10.1111/ggi.12843
   Araki A, 2012, GERIATR GERONTOL INT, V12, P7, DOI 10.1111/j.1447-0594.2011.00808.x
   Araki E, 2020, DIABETOL INT, V11, P165, DOI [10.1111/jdi.13306, 10.1007/s13340-020-00439-5]
   Atkins JL, 2014, J AM GERIATR SOC, V62, P253, DOI 10.1111/jgs.12652
   Balboa-Castillo T, 2018, AGE AGEING, V47, P872, DOI 10.1093/ageing/afy105
   Bauer JM, 2015, J AM MED DIR ASSOC, V16, P740, DOI 10.1016/j.jamda.2015.05.021
   Bays HE, 2013, AM J CARDIOVASC DRUG, V13, P37, DOI 10.1007/s40256-012-0002-3
   Benedict C, 2018, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00215
   Bhatt DL, 2019, NEW ENGL J MED, V380, P11, DOI 10.1056/NEJMoa1812792
   Bhatti JS, 2017, BBA-MOL BASIS DIS, V1863, P1066, DOI 10.1016/j.bbadis.2016.11.010
   Blaum CS, 2007, J GERONTOL A-BIOL, V62, P766, DOI 10.1093/gerona/62.7.766
   Bo YC, 2019, CLIN NUTR, V38, P159, DOI 10.1016/j.clnu.2017.12.020
   Bolzetta F, 2018, EXP GERONTOL, V101, P1, DOI 10.1016/j.exger.2017.11.007
   Bonaccio M, 2018, BRIT J NUTR, V120, P841, DOI 10.1017/S0007114518002179
   Brainard JS, 2020, J AM MED DIR ASSOC, V21, P1439, DOI 10.1016/j.jamda.2020.02.022
   Brown AE, 2016, CURR CARDIOL REP, V18, DOI 10.1007/s11886-016-0755-4
   Byrn MA, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/5696391
   Cangussu LM, 2015, OSTEOPOROSIS INT, V26, P2413, DOI 10.1007/s00198-015-3151-9
   Carney Erin, 2006, Nutr Clin Pract, V21, P188, DOI 10.1177/0115426506021002188
   Cederholm T, 2019, CLIN NUTR, V38, P1, DOI [10.1002/jcsm.12383, 10.1016/j.clnu.2018.08.002, 10.1016/j.clnu.2019.02.033, 10.1002/jpen.1440]
   Cefalu WT, 2019, DIABETES CARE, V42, pS139, DOI [10.2337/dc19-S012, 10.2337/dc19s012]
   Charvat H, 2015, J DIABETES INVEST, V6, P533, DOI 10.1111/jdi.12333
   Chatterjee S, 2016, DIABETES CARE, V39, P300, DOI 10.2337/dc15-1588
   Chen LK, 2020, J AM MED DIR ASSOC, V21, P300, DOI 10.1016/j.jamda.2019.12.012
   Chhetri JK, 2017, BMC GERIATR, V17, DOI 10.1186/s12877-017-0439-y
   Chitnis T, 2017, J CLIN INVEST, V127, P3577, DOI 10.1172/JCI90609
   Cleasby ME, 2016, J ENDOCRINOL, V229, pR67, DOI 10.1530/JOE-15-0533
   Coelho HJ, 2018, NUTRIENTS, V10, DOI 10.3390/nu10091330
   Cox DJ, 2005, DIABETES CARE, V28, P71, DOI 10.2337/diacare.28.1.71
   Cruz-Jentoft AJ, 2019, AGE AGEING, V48, P16, DOI 10.1093/ageing/afy169
   Cui Hang, 2012, J Signal Transduct, V2012, P646354, DOI 10.1155/2012/646354
   Cukierman-Yaffe T, 2014, LANCET DIABETES ENDO, V2, P562, DOI 10.1016/S2213-8587(14)70062-2
   Dass AS, 2018, J ADV PHARM TECHNOL, V9, P32, DOI 10.4103/japtr.JAPTR_309_17
   de Abreu D.A. Fernandes., 2009, Psychoneuroendocrinology, V34, pS265
   de Oliveira MC, 2018, CIRCULATION, V138, pE160, DOI 10.1161/CIR.0000000000000595
   Devore EE, 2013, AM J EPIDEMIOL, V177, P33, DOI 10.1093/aje/kws202
   Devore EE, 2009, DIABETES CARE, V32, P635, DOI 10.2337/dc08-1741
   Dik MG, 2007, DIABETES CARE, V30, P2655, DOI 10.2337/dc06-1190
   Dorcely B, 2021, CURR DIABETES REV, V17, P243, DOI 10.2174/1573399816666200316112709
   Dvoretskiy S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030715
   Dympna G., 1999, COMMITTEE MILITARY N
   Ebadi SA, 2018, DIAB MET SYND CLIN R, V12, P893, DOI 10.1016/j.dsx.2018.05.011
   El Hajj C, 2018, ARCH OSTEOPOROS, V14, DOI 10.1007/s11657-018-0553-2
   Eyles DW, 2005, J CHEM NEUROANAT, V29, P21, DOI 10.1016/j.jchemneu.2004.08.006
   Fard NRP, 2019, NUTR REV, V77, P498, DOI 10.1093/nutrit/nuz007
   Ferrucci L, 2018, NAT REV CARDIOL, V15, P505, DOI 10.1038/s41569-018-0064-2
   Forbes SC, 2015, CAN GERIATR J, V18, P231, DOI 10.5770/cgj.18.189
   Freeman J, 2019, POSTGRAD MED, V131, P241, DOI 10.1080/00325481.2019.1578590
   Fried LP, 2001, J GERONTOL A-BIOL, V56, pM146, DOI 10.1093/gerona/56.3.M146
   Gale CR, 2017, J AM GERIATR SOC, V65, P1289, DOI 10.1111/jgs.14787
   García-Esquinas E, 2015, J AM MED DIR ASSOC, V16, P748, DOI 10.1016/j.jamda.2015.04.008
   Geller AI, 2014, JAMA INTERN MED, V174, P678, DOI 10.1001/jamainternmed.2014.136
   Goodwill AM, 2017, J AM GERIATR SOC, V65, P2161, DOI 10.1111/jgs.15012
   Granic A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11040745
   Gregg EW, 2018, DIABETES CARE, V41, P1040, DOI 10.2337/dc17-2110
   Guh DP, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-88
   Han ES, 2014, INT PSYCHOGERIATR, V26, P155, DOI 10.1017/S1041610213001841
   Hanach NI, 2019, ADV NUTR, V10, P59, DOI 10.1093/advances/nmy065
   Haroon NN, 2015, DIABETES CARE, V38, P1868, DOI 10.2337/dc15-0491
   Hillier TA, 2005, DIABETES CARE, V28, P2258, DOI 10.2337/diacare.28.9.2258
   Hirani V, 2017, AGE AGEING, V46, P413, DOI 10.1093/ageing/afw214
   Hirata Y, 2019, JCI INSIGHT, V4, DOI 10.1172/jci.insight.124952
   Hong SH, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21020494
   Houston DK, 2018, J GERONTOL A-BIOL, V73, P1552, DOI 10.1093/gerona/glx204
   Hutchins-Wiese HL, 2013, J NUTR HEALTH AGING, V17, P76, DOI 10.1007/s12603-012-0415-3
   Iimuro S, 2012, GERIATR GERONTOL INT, V12, P59, DOI 10.1111/j.1447-0594.2011.00813.x
   Isanejad M, 2020, EUR J NUTR, V59, P1181, DOI 10.1007/s00394-019-01978-7
   Jang HC, 2016, DIABETES METAB J, V40, P182, DOI 10.4093/dmj.2016.40.3.182
   Jayanama K, 2020, NUTRITION, V70, DOI 10.1016/j.nut.2019.110610
   Ju SY, 2018, BMC GERIATR, V18, DOI 10.1186/s12877-018-0904-2
   Kalyani RR, 2017, DIABETES CARE, V40, P440, DOI 10.2337/dci17-0005
   Katakami N, 2018, J ATHEROSCLER THROMB, V25, P27, DOI 10.5551/jat.RV17014
   Kim TN, 2010, DIABETES CARE, V33, P1497, DOI 10.2337/dc09-2310
   Kodl CT, 2008, ENDOCR REV, V29, P494, DOI 10.1210/er.2007-0034
   Kojima G, 2018, J AM GERIATR SOC, V66, P783, DOI 10.1111/jgs.15251
   Kojima G, 2016, J AM MED DIR ASSOC, V17, P881, DOI 10.1016/j.jamda.2016.05.013
   Komulainen P, 2007, DEMENT GERIATR COGN, V23, P29, DOI 10.1159/000096636
   Kong SH, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-017-18998-0
   Kwok T, 2017, CLIN NUTR, V36, P1509, DOI 10.1016/j.clnu.2016.10.018
   Laudisio A, 2014, CLIN NUTR, V33, P626, DOI 10.1016/j.clnu.2013.08.005
   Lee AK, 2020, J CLIN ENDOCR METAB, V105, P152, DOI 10.1210/clinem/dgz045
   Lejri I, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/9695412
   Levine ME, 2014, CELL METAB, V19, P407, DOI 10.1016/j.cmet.2014.02.006
   Li Y, 2020, J NUTR HEALTH AGING, V24, P223, DOI 10.1007/s12603-020-1317-4
   Littlejohns TJ, 2014, NEUROLOGY, V83, P920, DOI 10.1212/WNL.0000000000000755
   Liu GX, 2017, GERIATR GERONTOL INT, V17, P2485, DOI 10.1111/ggi.13110
   Lopez-Garcia E, 2018, AM J CLIN NUTR, V107, P763, DOI 10.1093/ajcn/nqy026
   Low S, 2020, CLIN NUTR, V39, P2274, DOI 10.1016/j.clnu.2019.10.019
   Maciejczyk M, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20040874
   Malara A, 2014, CLIN INTERV AGING, V9, P105, DOI 10.2147/CIA.S54611
   Marseglia A, 2019, DIABETES CARE, V42, P232, DOI 10.2337/dc18-1428
   Martínez-González MA, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0103246
   Mattei J, 2019, DIABETES CARE, V42, P1372, DOI 10.2337/dc19-0130
   McIntosh EC, 2019, DIABETES CARE, V42, P972, DOI 10.2337/dc18-1399
   Mitnitski A, 2011, J NUTR HEALTH AGING, V15, P863, DOI 10.1007/s12603-011-0066-9
   Miyazawa I, 2018, ENDOCR J, V65, P527, DOI [10.1507/endocrj.EJ17-0415, 10.1507/endocrj.ej17-0415]
   Moghaddam HS, 2019, FRONT NEUROENDOCRIN, V55, DOI 10.1016/j.yfrne.2019.100782
   Mohseni Simin, 2014, Handb Clin Neurol, V126, P513, DOI 10.1016/B978-0-444-53480-4.00036-9
   Monami M, 2008, J GERONTOL A-BIOL, V63, P646, DOI 10.1093/gerona/63.6.646
   Moore EM, 2013, DIABETES CARE, V36, P2981, DOI 10.2337/dc13-0229
   Morris MC, 2006, J ALZHEIMERS DIS, V9, P435
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Mozaffarian D, 2011, J AM COLL CARDIOL, V58, P2047, DOI 10.1016/j.jacc.2011.06.063
   multicenter collaboration group of Department of S Technology of Guangdong P Health Commission of Guangdong Province for chloroquine in the treatment of novel coronavirus p, 2020, ZHONGHUA JIE HE HE H, V43, pE019, DOI DOI 10.2337/DC20-S012
   Murphy MP, 2009, BIOCHEM J, V417, P1, DOI 10.1042/BJ20081386
   Muscariello E, 2016, CLIN INTERV AGING, V11, DOI 10.2147/CIA.S96017
   Nakamura K, 2021, J EPIDEMIOL, V31, P320, DOI 10.2188/jea.JE20190289
   Nam GE, 2019, DIABETES CARE, V42, P1217, DOI 10.2337/dc18-1667
   Namba M, 2018, J DIABETES INVEST, V9, P642, DOI 10.1111/jdi.12790
   Neergaard JS, 2017, DIABETES, V66, P1957, DOI 10.2337/db16-1444
   Oda E, 2012, ACTA DIABETOL, V49, P89, DOI 10.1007/s00592-011-0309-6
   Ogama N, 2019, J CLIN MED, V8, DOI 10.3390/jcm8030319
   Okamura T, 2020, J CLIN BIOCHEM NUTR, V66, P233, DOI 10.3164/jcbn.19-85
   Omura T, 2020, GERIATR GERONTOL INT, V20, P59, DOI 10.1111/ggi.13820
   Osuka Y, 2019, J NUTR HEALTH AGING, V23, P425, DOI 10.1007/s12603-019-1166-1
   Otsuka R, 2019, J NUTR HEALTH AGING, V23, P89, DOI 10.1007/s12603-018-1124-3
   Otto MCD, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0141341
   Palta P, 2014, J INT NEUROPSYCH SOC, V20, P278, DOI 10.1017/S1355617713001483
   Park JM, 2019, J NUTR HEALTH AGING, V23, P930, DOI 10.1007/s12603-019-1249-z
   Park Y, 2018, AM J CLIN NUTR, V108, P1026, DOI 10.1093/ajcn/nqy214
   Patel P, 2017, J CHEM NEUROANAT, V85, P36, DOI 10.1016/j.jchemneu.2017.06.007
   Pedersen BK, 2009, J PHYSIOL-LONDON, V587, P5559, DOI 10.1113/jphysiol.2009.179515
   Pilemann-Lyberg S, 2015, DIABETES RES CLIN PR, V110, P202, DOI 10.1016/j.diabres.2015.09.006
   Praticò D, 2002, ARCH NEUROL-CHICAGO, V59, P972, DOI 10.1001/archneur.59.6.972
   Rahi B, 2016, EUR J NUTR, V55, P1729, DOI 10.1007/s00394-015-0991-1
   Rawlings AM, 2017, DIABETES CARE, V40, P879, DOI 10.2337/dc16-2203
   Rawlings AM, 2014, ANN INTERN MED, V161, P785, DOI 10.7326/M14-0737
   Roberts RO, 2012, J ALZHEIMERS DIS, V32, P329, DOI 10.3233/JAD-2012-120862
   Rockwood K, 2005, CAN MED ASSOC J, V173, P489, DOI 10.1503/cmaj.050051
   Rodríguez-Mañas L, 2021, CLIN NUTR, V40, P1192, DOI 10.1016/j.clnu.2020.07.032
   Rubenstein LZ, 2001, J GERONTOL A-BIOL, V56, pM366, DOI 10.1093/gerona/56.6.M366
   Sakurai T, 2012, GERIATR GERONTOL INT, V12, P117, DOI 10.1111/j.1447-0594.2011.00819.x
   Sakurai T, 2010, GERONTOLOGY, V56, P141, DOI 10.1159/000246970
   Sanada F, 2018, FRONT CARDIOVASC MED, V5, DOI 10.3389/fcvm.2018.00012
   París AS, 2013, NUTR HOSP, V28, P592, DOI 10.3305/nh.2013.28.3.6472
   Satake S, 2016, GERIATR GERONTOL INT, V16, P709, DOI 10.1111/ggi.12543
   Sato E, 2004, DIABETES CARE, V27, P1271, DOI 10.2337/diacare.27.6.1271
   Schaap LA, 2013, EPIDEMIOL REV, V35, P51, DOI 10.1093/epirev/mxs006
   Schloot NC, 2016, DIABETES-METAB RES, V32, P316, DOI 10.1002/dmrr.2722
   Schoufour JD, 2019, BRIT J NUTR, V121, P393, DOI 10.1017/S0007114518003367
   Scicchitano BM, 2018, MECH AGEING DEV, V170, P37, DOI 10.1016/j.mad.2017.08.009
   Scott D, 2017, J BONE MINER RES, V32, P575, DOI 10.1002/jbmr.3016
   Scott D, 2016, CALCIFIED TISSUE INT, V99, P30, DOI 10.1007/s00223-016-0123-9
   Scott D, 2010, CLIN ENDOCRINOL, V73, P581, DOI 10.1111/j.1365-2265.2010.03858.x
   Sfyri P, 2017, J BIOMED SCI, V24, DOI 10.1186/s12929-017-0346-8
   Shokolenko I, 2009, NUCLEIC ACIDS RES, V37, P2539, DOI 10.1093/nar/gkp100
   Sieber CC, 2019, AGING CLIN EXP RES, V31, P793, DOI 10.1007/s40520-019-01170-1
   Silva R, 2018, J NUTR HEALTH AGING, V22, P655, DOI 10.1007/s12603-017-0993-1
   Smith GI, 2015, AM J CLIN NUTR, V102, P115, DOI 10.3945/ajcn.114.105833
   Sone H, 2002, HORM METAB RES, V34, P509, DOI 10.1055/s-2002-34791
   Suh SW, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041168
   Suh SW, 2003, J NEUROSCI, V23, P10681
   Tamura Y, 2021, J DIABETES INVEST, V12, P633, DOI 10.1111/jdi.13379
   Tamura Y, 2017, FRONT AGING NEUROSCI, V9, DOI 10.3389/fnagi.2017.00220
   Tamura Y, 2015, GERIATR GERONTOL INT, V15, P34, DOI 10.1111/ggi.12666
   Tanaka S, 2014, J CLIN ENDOCR METAB, V99, pE2692, DOI 10.1210/jc.2014-1855
   Tepper S, 2018, NUTRIENTS, V10, DOI 10.3390/nu10060767
   Thein FS, 2018, POSTGRAD MED, V130, P561, DOI 10.1080/00325481.2018.1491779
   Aung T, 2018, JAMA CARDIOL, V3, P225, DOI 10.1001/jamacardio.2017.5205
   Tieland M, 2017, J NUTR HEALTH AGING, V21, P994, DOI 10.1007/s12603-017-0896-1
   Toyoshima K, 2020, GERIATR GERONTOL INT, V20, P1157, DOI 10.1111/ggi.14057
   Toyoshima K, 2018, GERIATR GERONTOL INT, V18, P1458, DOI 10.1111/ggi.13512
   Tsalamandris S, 2019, EUR CARDIOL REV, V14, P50, DOI 10.15420/ecr.2018.33.1
   Turnbull P J, 2002, J Nutr Health Aging, V6, P185
   Ullah A, 2016, SAUDI PHARM J, V24, P547, DOI 10.1016/j.jsps.2015.03.013
   Umegaki H, 2015, J DIABETES INVEST, V6, P623, DOI 10.1111/jdi.12365
   Umegaki H, 2012, GERIATR GERONTOL INT, V12, P110, DOI 10.1111/j.1447-0594.2011.00818.x
   Uretsky S, 2007, AM J MED, V120, P863, DOI 10.1016/j.amjmed.2007.05.011
   Valenzuela PL, 2020, AGEING RES REV, V62, DOI 10.1016/j.arr.2020.101108
   Valls-Pedret C, 2015, JAMA INTERN MED, V175, P1094, DOI 10.1001/jamainternmed.2015.1668
   Vellas B, 1999, NUTRITION, V15, P116, DOI 10.1016/S0899-9007(98)00171-3
   Verlaan S, 2017, J AM MED DIR ASSOC, V18, P374, DOI 10.1016/j.jamda.2016.12.074
   Volkert D, 2019, CLIN NUTR, V38, P10, DOI 10.1016/j.clnu.2018.05.024
   Walston J, 2002, ARCH INTERN MED, V162, P2333, DOI 10.1001/archinte.162.20.2333
   Watanabe D, 2021, J GERONTOL A-BIOL, V76, P876, DOI 10.1093/gerona/glaa133
   Watanabe D, 2020, J CLIN MED, V9, DOI 10.3390/jcm9051367
   Watanabe D, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111744
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Wengreen HJ, 2007, J NUTR HEALTH AGING, V11, P230
   Whitmer RA, 2007, CURR ALZHEIMER RES, V4, P117, DOI 10.2174/156720507780362065
   Whitmer RA, 2009, JAMA-J AM MED ASSOC, V301, P1565, DOI 10.1001/jama.2009.460
   Wintermeyer E, 2016, NUTRIENTS, V8, DOI 10.3390/nu8060319
   Wong E, 2013, LANCET DIABETES ENDO, V1, P106, DOI 10.1016/S2213-8587(13)70046-9
   World Health Organization, 2019, Risk reduction of cognitive decline and dementia: WHO guidelines
   Wu L, 2017, SCI REP-UK, V7, DOI 10.1038/srep41317
   Xue M, 2019, AGEING RES REV, V55, DOI 10.1016/j.arr.2019.100944
   Yabe D, 2017, DIABETES OBES METAB, V19, P739, DOI 10.1111/dom.12848
   Yaffe K, 2007, J AM GERIATR SOC, V55, P758, DOI 10.1111/j.1532-5415.2007.01139.x
   Yamaoka T, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061629
   Yanase T, 2018, ENDOCR J, V65, P1, DOI 10.1507/endocrj.EJ17-0390
   Yogi-Morren Divya, 2014, Cardiovasc Psychiatry Neurol, V2014, P656341, DOI 10.1155/2014/656341
   Yoshimura Y, 2012, GERIATR GERONTOL INT, V12, P29, DOI 10.1111/j.1447-0594.2011.00810.x
   Zhang X, 2004, INT J OBESITY, V28, P734, DOI 10.1038/sj.ijo.0802634
   Zhang XW, 2016, AGING CLIN EXP RES, V28, P165, DOI 10.1007/s40520-015-0381-9
NR 202
TC 131
Z9 136
U1 10
U2 64
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2020
VL 12
IS 11
AR 3367
DI 10.3390/nu12113367
PG 29
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA OY8RQ
UT WOS:000594508600001
PM 33139628
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bowden-Davies, K
   Connolly, J
   Burghardt, P
   Koch, LG
   Britton, SL
   Burniston, JG
AF Bowden-Davies, Kelly
   Connolly, Joanne
   Burghardt, Paul
   Koch, Lauren G.
   Britton, Steven L.
   Burniston, Jatin G.
TI Label-free profiling of white adipose tissue of rats exhibiting high or
   low levels of intrinsic exercise capacity
SO PROTEOMICS
LA English
DT Article
DE Adipokines; Aerobic capacity; Animal proteomics; Label-free
   quantitation; Metabolic syndrome; Obesity
ID LOW AEROBIC CAPACITY; HIGH-FAT DIET; DATA-INDEPENDENT ANALYSIS;
   ARTIFICIAL SELECTION; ADIPOCYTE PROTEOME; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; RUNNING CAPACITY; SKELETAL-MUSCLE
AB Divergent selection has created rat phenotypes of high- and low-capacity runners (HCR and LCR, respectively) that have differences in aerobic capacity and correlated traits such as adiposity. We analyzed visceral adipose tissue of HCR and LCR using label-free high-definition MS (elevated energy) profiling. The running capacity of HCR was ninefold greater than LCR. Proteome profiling encompassed 448 proteins and detected 30 significant (p <0.05; false discovery rate <10%, calculated using q-values) differences. Approximately half of the proteins analyzed were of mitochondrial origin, but there were no significant differences in the abundance of proteins involved in aerobic metabolism. Instead, adipose tissue of LCR rats exhibited greater abundances of proteins associated with adipogenesis (e.g. cathepsin D), ER stress (e.g. 78 kDa glucose response protein), and inflammation (e.g. Ig gamma-2B chain C region). Whereas the abundance antioxidant enzymes such as superoxide dismutase [Cu-Zn] was greater in HCR tissue. Putative adipokines were also detected, in particular protein S100-B, was 431% more abundant in LCR adipose tissue. These findings reveal low running capacity is associated with a pathological profile in visceral adipose tissue proteome despite no detectable differences in mitochondrial protein abundance.
C1 [Bowden-Davies, Kelly; Burniston, Jatin G.] Liverpool John Moores Univ, Res Inst Sport & Exercise Sci, Liverpool L3 3AF, Merseyside, England.
   [Connolly, Joanne] Waters MSHQ, Manchester, Lancs, England.
   [Burghardt, Paul; Koch, Lauren G.; Britton, Steven L.] Univ Michigan, Dept Anaesthesiol, Ann Arbor, MI 48109 USA.
   [Britton, Steven L.] Norwegian Univ Sci & Technol, KG Jebsen Ctr Exercise Med, Dept Circulat & Med Imaging, N-7034 Trondheim, Norway.
C3 Liverpool John Moores University; Waters UK; University of Michigan
   System; University of Michigan; Norwegian University of Science &
   Technology (NTNU)
RP Burniston, JG (corresponding author), Liverpool John Moores Univ, Res Inst Sport & Exercise Sci, Muscle Physiol & Prote Lab, Tom Reilly Bldg,Byrom St, Liverpool L3 3AF, Merseyside, England.
EM j.burniston@ljmu.ac.uk
RI Burniston, Jatin/AAB-8831-2020; Koch, Lauren/D-1258-2010
OI Ballantyne (Connolly), Joanne/0009-0008-6815-6198; Bowden Davies, Kelly
   A/0000-0002-9448-0732
FU Office of Research Infrastructure Programs/OD [R24OD010950]; National
   Institutes of Health [R01DK099034, R01DK077200, R01GM104194]; National
   Institute of Diabetes and Digestive and Kidney Diseases [P30DK020572]
   Funding Source: NIH RePORTER
FX The LCR-HCR rat model system was funded by the Office of Research
   Infrastructure Programs/OD grant R24OD010950 and by grant R01DK099034
   (to L.G.K. and S.L.B.) from the National Institutes of Health. S.L.B.
   was also supported by National Institutes of Health grants R01DK077200,
   and R01GM104194. We acknowledge the expert care of the rat colony
   provided by Molly Kalahar and Lori Heckenkamp. Contact L.G.K.
   (lgkoch@med.umich.edu) or S.L.B. (brittons@umich.edu) for information on
   the LCR and HCR rats: these rat models are maintained as an
   international resource with support from the Department of
   Anaesthesiology at the University of Michigan, Ann Arbor, MI, USA.
CR Adachi J, 2007, MOL CELL PROTEOMICS, V6, P1257, DOI 10.1074/mcp.M600476-MCP200
   Basseri S, 2009, J LIPID RES, V50, P2486, DOI 10.1194/jlr.M900216-JLR200
   Bowman TA, 2010, ENDOCRINOLOGY, V151, P5157, DOI 10.1210/en.2010-0176
   Bull VH, 2012, ELECTROPHORESIS, V33, P1814, DOI 10.1002/elps.201100565
   Burniston JG, 2011, PROTEOMICS, V11, P3369, DOI 10.1002/pmic.201000593
   Csordas A, 2012, DATABASE-OXFORD, DOI 10.1093/database/bas004
   DeFuria J, 2013, P NATL ACAD SCI USA, V110, P5133, DOI 10.1073/pnas.1215840110
   DeMarco VG, 2012, AM J PHYSIOL-HEART C, V302, pH1667, DOI 10.1152/ajpheart.01027.2011
   Deng JN, 2012, J BIOL CHEM, V287, P6240, DOI 10.1074/jbc.M111.299115
   Després JP, 2008, ARTERIOSCL THROM VAS, V28, P1039, DOI 10.1161/ATVBAHA.107.159228
   Duffaut C, 2009, BIOCHEM BIOPH RES CO, V384, P482, DOI 10.1016/j.bbrc.2009.05.002
   Franceschini A, 2013, NUCLEIC ACIDS RES, V41, pD808, DOI 10.1093/nar/gks1094
   Fujiya A, 2014, OBESITY, V22, P371, DOI 10.1002/oby.20532
   Gustafson B, 2007, ARTERIOSCL THROM VAS, V27, P2276, DOI 10.1161/ATVBAHA.107.147835
   Gutierrez-Aguilar R, 2012, OBESITY, V20, P306, DOI 10.1038/oby.2011.236
   Huang DW, 2009, NAT PROTOC, V4, P44, DOI 10.1038/nprot.2008.211
   Huang DW, 2009, NUCLEIC ACIDS RES, V37, P1, DOI 10.1093/nar/gkn923
   Jager J, 2010, DIABETES, V59, P61, DOI 10.2337/db09-0470
   Koch LG, 2011, CIRC RES, V109, P1162, DOI 10.1161/CIRCRESAHA.111.253807
   Koch LG, 2001, PHYSIOL GENOMICS, V5, P45, DOI 10.1152/physiolgenomics.2001.5.1.45
   Lass A, 2006, CELL METAB, V3, P309, DOI 10.1016/j.cmet.2006.03.005
   Lehr S, 2012, MOL CELL PROTEOMICS, V11, DOI 10.1074/mcp.M111.010504
   Lessard SJ, 2011, AM J PHYSIOL-REG I, V300, pR175, DOI 10.1152/ajpregu.00338.2010
   Levin Y, 2011, PROTEOMICS, V11, P3273, DOI 10.1002/pmic.201000661
   Li GZ, 2009, PROTEOMICS, V9, P1696, DOI 10.1002/pmic.200800564
   Liu XJ, 2009, J PROTEOME RES, V8, P1255, DOI 10.1021/pr800850a
   Masson O, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016452
   Morris EM, 2009, AM J NEPHROL, V30, P112, DOI 10.1159/000204362
   Naples SP, 2010, APPL PHYSIOL NUTR ME, V35, P151, DOI 10.1139/H09-139
   Noland RC, 2007, AM J PHYSIOL-ENDOC M, V293, pE31, DOI 10.1152/ajpendo.00500.2006
   Novak CM, 2010, HORM BEHAV, V58, P355, DOI 10.1016/j.yhbeh.2010.03.013
   Pham N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012691
   Rivas DA, 2011, AM J PHYSIOL-REG I, V300, pR835, DOI 10.1152/ajpregu.00659.2010
   Roca-Rivada A, 2011, J PROTEOMICS, V74, P1068, DOI 10.1016/j.jprot.2011.03.010
   Rosenow A, 2010, J PROTEOME RES, V9, P5389, DOI 10.1021/pr100621g
   Silva JC, 2006, MOL CELL PROTEOMICS, V5, P144, DOI 10.1074/mcp.M500230-MCP200
   Steiner J, 2010, CARDIOVASC PSYCHIAT, V2010
   Steiner J, 2010, PSYCHONEUROENDOCRINO, V35, P321, DOI 10.1016/j.psyneuen.2009.07.012
   Stephenson EJ, 2013, AM J PHYSIOL-ENDOC M, V305, pE429, DOI 10.1152/ajpendo.00544.2012
   Svensson A, 2009, CELL MOL BIOL LETT, V14, P128, DOI 10.2478/s11658-008-0039-0
   Thyfault JP, 2009, J PHYSIOL-LONDON, V587, P1805, DOI 10.1113/jphysiol.2009.169060
   Tweedie C, 2011, AM J PHYSIOL-REG I, V300, pR544, DOI 10.1152/ajpregu.00250.2010
   Winer DA, 2011, NAT MED, V17, P610, DOI 10.1038/nm.2353
   Wisloff U, 2005, SCIENCE, V307, P418, DOI 10.1126/science.1108177
   Xie XT, 2010, J PROTEOME RES, V9, P4521, DOI 10.1021/pr100268f
   ZUCKER LM, 1961, J HERED, V52, P275, DOI 10.1093/oxfordjournals.jhered.a107093
NR 46
TC 9
Z9 13
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1615-9853
EI 1615-9861
J9 PROTEOMICS
JI Proteomics
PD JUL
PY 2015
VL 15
IS 13
BP 2342
EP 2349
DI 10.1002/pmic.201400537
PG 8
WC Biochemical Research Methods; Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CL9BA
UT WOS:000357267700022
PM 25758023
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Botezelli, JD
   Cambri, LT
   Ghezzi, AC
   Dalia, RA
   Scariot, PPM
   Ribeiro, C
   Voltarelli, FA
   Mello, MAR
AF Botezelli, Jose D.
   Cambri, Lucieli T.
   Ghezzi, Ana C.
   Dalia, Rodrigo A.
   Scariot, Pedro P. M.
   Ribeiro, Carla
   Voltarelli, Fabricio A.
   Mello, Maria A. R.
TI Different exercise protocols improve metabolic syndrome markers, tissue
   triglycerides content and antioxidant status in rats
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Physical exercise; liver damage; oxidative stress; rats
ID LACTATE STEADY-STATE; INSULIN-RESISTANCE; OXIDATIVE STRESS; WEIGHT-LOSS;
   OBESITY; LIVER; OVERWEIGHT; DISEASE; GLUCOSE; WOMEN
AB Background: An increase in the prevalence of obesity entails great expenditure for governments. Physical exercise is a powerful tool in the combat against obesity and obesity-associated diseases. This study sought to determine the effect of three different exercise protocols on metabolic syndrome and lipid peroxidation markers and the activity of antioxidant enzymes in adult Wistar rats (120 days old).
   Methods: Animals were randomly divided into four groups: the control (C) group was kept sedentary throughout the study; the aerobic group (A) swam1 h per day, 5 days per week, at 80% lactate threshold intensity; the strength group (S) performed strength training with four series of 10 jumps, 5 days per week; and the Concurrent group (AS) was trained using the aerobic protocol three days per week and the strength protocol two days per week.
   Results: Groups A and S exhibited a reduction in body weight compared to group C. All exercised animals showed a reduction in triglyceride concentrations in fatty tissues and the liver. Exercised animals also exhibited a reduction in lipid peroxidation markers (TBARS) and an increase in serum superoxide dismutase activity. Animals in group A had increased levels of liver catalase and superoxide dismutase activities.
   Conclusions: We concluded that all physical activity protocols improved the antioxidant systems of the animals and decreased the storage of triglycerides in the investigated tissues.
C1 [Botezelli, Jose D.; Cambri, Lucieli T.; Ghezzi, Ana C.; Dalia, Rodrigo A.; Scariot, Pedro P. M.; Ribeiro, Carla; Mello, Maria A. R.] Sao Paulo State Univ UNESP, Dept Phys Educ, BR-13607331 Rio Claro, Brazil.
   [Voltarelli, Fabricio A.] Mato Grosso Fed Univ UFMT, Dept Phys Educ, BR-78550000 Culaba, Brazil.
C3 Universidade Estadual Paulista; Universidade Federal de Mato Grosso do
   Sul
RP Botezelli, JD (corresponding author), Sao Paulo State Univ UNESP, Dept Phys Educ, 24-A Av 1515, BR-13607331 Rio Claro, Brazil.
EM jdbotezelli@yahoo.com.br
RI Cambri, Lucieli/I-5964-2012; Scariot, Pedro/W-3268-2017; Voltarelli,
   Fabrício/M-6496-2019
OI Scariot, Pedro/0000-0003-2976-8999
CR Aebi H, 1984, Methods Enzymol, V105, P121
   [Anonymous], METODOS BIOQUIMICA C
   Behzad MK, 2010, INT J ENDOCRINOL MET, V8, P206
   Billat VL, 2003, SPORTS MED, V33, P407, DOI 10.2165/00007256-200333060-00003
   Botezelli JD, 2010, DIABETOL METAB SYNDR, V2, P1
   Botezelli JD, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-116
   Botezelli JD, 2010, MOTRIZ, V16, P231
   Brooks Naomi, 2006, Int J Med Sci, V4, P19
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   de Araujo GG, 2007, COMP BIOCHEM PHYS A, V148, P888, DOI 10.1016/j.cbpa.2007.09.002
   Dhalla NS, 2000, J HYPERTENS, V18, P655, DOI 10.1097/00004872-200018060-00002
   DOGAN P, 1994, CLIN BIOCHEM, V27, P413, DOI 10.1016/0009-9120(94)90046-9
   Donnelly JE, 2003, ARCH INTERN MED, V163, P1343, DOI 10.1001/archinte.163.11.1343
   Dyck DJ, 1998, AM J PHYSIOL-ENDOC M, V275, pE888, DOI 10.1152/ajpendo.1998.275.5.E888
   ENGEL PC, 1978, ANAL BIOCHEM, V88, P475, DOI 10.1016/0003-2697(78)90447-5
   Ervin R Bethene, 2009, Natl Health Stat Report, P1
   Franks PW, 2006, J HUM HYPERTENS, V20, P837, DOI 10.1038/sj.jhh.1002059
   Girard A, 2006, NUTRITION, V22, P758, DOI 10.1016/j.nut.2006.05.006
   Gobatto CA, 2001, COMP BIOCHEM PHYS A, V130, P21, DOI 10.1016/S1095-6433(01)00362-2
   Griffin ME, 1999, DIABETES, V48, P1270, DOI 10.2337/diabetes.48.6.1270
   Hammond RA, 2010, DIABETES METAB SYNDR, V3, P285, DOI [10.2147/DMSOTT.S7384, 10.2147/DMSO.S7384]
   Hanley AJG, 2005, DIABETES, V54, P3140, DOI 10.2337/diabetes.54.11.3140
   Ivy J L, 1997, Sports Med, V24, P321
   Jakicic JM, 2003, JAMA-J AM MED ASSOC, V290, P1323, DOI 10.1001/jama.290.10.1323
   Kakkar R, 1998, CLIN SCI, V94, P623, DOI 10.1042/cs0940623
   Kelley GL, 2004, ENDOCRINOLOGY, V145, P548, DOI 10.1210/en.2003-1167
   Kim D, 2006, SOC SCI MED, V63, P1045, DOI 10.1016/j.socscimed.2006.02.017
   Koh KK, 2005, J AM COLL CARDIOL, V46, P1978, DOI 10.1016/j.jacc.2005.06.082
   Kraemer WJ, 1997, J APPL PHYSIOL, V83, P270, DOI 10.1152/jappl.1997.83.1.270
   Kraus WE, 2002, NEW ENGL J MED, V347, P1483, DOI 10.1056/NEJMoa020194
   Lehninger AL, 1993, PRINCIPLES BIOCH, V2
   Lundbaeck K, 1961, BMJ-BRIT MED J, V2, P1507
   MARTIN WH, 1993, AM J PHYSIOL, V265, pE708, DOI 10.1152/ajpendo.1993.265.5.E708
   MATTHEWS JNS, 1990, BMJ-BRIT MED J, V300, P230, DOI 10.1136/bmj.300.6719.230
   McAardle WD, 1998, FISIOLOGIA EXERCICIO, V4
   MIDDLETON JE, 1959, BRIT MED J, V1, P824, DOI 10.1136/bmj.1.5125.824
   Perseghin G, 1996, NEW ENGL J MED, V335, P1357, DOI 10.1056/NEJM199610313351804
   POEHLMAN ET, 1991, AM J PHYSIOL, V261, pE233, DOI 10.1152/ajpendo.1991.261.2.E233
   Robatto GP, 2001, BRAZILIAN J PHYS S2, V6, P39
   Rogatto GP, 2001, MOTRIZ S2, V7, P75
   Samuel VT, 2004, J BIOL CHEM, V279, P32345, DOI 10.1074/jbc.M313478200
   SCHULZ LO, 1994, AM J CLIN NUTR, V60, P676, DOI 10.1093/ajcn/60.5.676
   TEGTBUR U, 1993, MED SCI SPORT EXER, V25, P620
   Voltarelli FA, 2002, BRAZ J MED BIOL RES, V35, P1389, DOI 10.1590/S0100-879X2002001100018
   WASOWICZ W, 1993, CLIN CHEM, V39, P2522
   Young JC, 1997, LIFE SCI, V61, P335, DOI 10.1016/S0024-3205(97)00390-1
NR 46
TC 22
Z9 25
U1 0
U2 12
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD DEC 19
PY 2011
VL 3
AR 35
DI 10.1186/1758-5996-3-35
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 915UW
UT WOS:000302053900001
PM 22182600
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nair, AR
   Mariappan, N
   Stull, AJ
   Francis, J
AF Nair, Anand R.
   Mariappan, Nithya
   Stull, April J.
   Francis, Joseph
TI Blueberry supplementation attenuates oxidative stress within monocytes
   and modulates immune cell levels in adults with metabolic syndrome: a
   randomized, double-blind, placebo-controlled trial
SO FOOD & FUNCTION
LA English
DT Article
ID DENDRITIC CELLS; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASES;
   VASCULAR FUNCTION; BLOOD-PRESSURE; DNA-DAMAGE; CONSUMPTION; OBESE;
   INFLAMMATION; STIMULATION
AB Background: Blueberries (BB) have been shown to improve insulin sensitivity and endothelial function in obese and pre-diabetic humans, and decrease oxidative stress and inflammation, and ameliorate cardiorenal damage in rodents. This indicates that blueberries have a systemic effect and are not limited to a particular organ system. In order for blueberries to exert beneficial effects on the whole body, the mechanism would logically have to operate through modulation of cellular humoral factors. Objective: This study investigated the role of blueberries in modulating immune cell levels and attenuating circulatory and monocyte inflammation and oxidative stress in metabolic syndrome (MetS) subjects. Design: A double-blind, randomized and placebo-controlled study was conducted in adults with MetS, in which they received a blueberry (22.5 g freeze-dried) or placebo smoothie twice daily for six weeks. Free radical production in the whole blood and monocytes, dendritic cell (DC) levels, expression of cytokines in monocytes and serum inflammatory markers were assessed pre-and post-intervention. Results: Baseline free radical levels in MetS subjects' samples were not different between groups. Treatment with blueberries markedly decreased superoxide and total reactive oxygen species (ROS) in whole blood and monocytes compared to the placebo (p <= 0.05). The baseline DC numbers in MetS subjects' samples in both groups were not different, however treatment with blueberries significantly increased myeloid DC (p = 0.05) and had no effect on plasmacytoid cells. Blueberry treatment decreased monocyte gene expression of TNF alpha, IL-6, TLR4 and reduced serum GMCSF in MetS subjects when compared to the placebo treatment (p <= 0.05). Conclusions: The findings of the current study demonstrate that blueberries exert immunomodulatory effects and attenuate oxidative stress and inflammation in adults with MetS.
C1 [Nair, Anand R.; Mariappan, Nithya; Francis, Joseph] Louisiana State Univ, Sch Vet Med, Comparat Biomed Sci, Baton Rouge, LA 70803 USA.
   [Stull, April J.] Univ Maryland Eastern Shore, Dept Human Ecol, Princess Anne, MD 21853 USA.
   [Stull, April J.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
   [Mariappan, Nithya] UAB, Sch Med, Div Mol & Translat Biomed, Dept Anesthesiol & Perioperat Med, Birmingham, AL 35294 USA.
C3 Louisiana State University School of Veterinary Medicine; Louisiana
   State University System; Louisiana State University; University System
   of Maryland; University of Maryland Eastern Shore; Louisiana State
   University System; Louisiana State University; Pennington Biomedical
   Research Center; University of Alabama System; University of Alabama
   Birmingham
RP Francis, J (corresponding author), Louisiana State Univ, Sch Vet Med, Comparat Biomed Sci, Baton Rouge, LA 70803 USA.
EM jfrancis@lsu.edu
RI Francis, Joseph/I-4984-2012
OI Francis, Joseph/0000-0002-9502-4579
FU United States Highbush Blueberry Council; National Center for
   Complementary and Integrative Health of the National Institutes of
   Health [K01AT006975, P50AT00277]; NORC Center Grant [2 P30
   DK072476-11A1]
FX Research reported in this publication was supported by the United States
   Highbush Blueberry Council (JF) and the National Center for
   Complementary and Integrative Health of the National Institutes of
   Health under award numbers K01AT006975 (AJS) and P50AT00277 (Botanical
   Dietary Supplements Research Center). This project used facilities that
   are supported in part by a NORC Center Grant # 2 P30 DK072476-11A1
   entitled "Pennington/Louisiana NORC". The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the United States Highbush Blueberry Council and the
   National Institutes of Health.
CR Ahmet I, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005954
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Astrup A, 2014, AM J CLIN NUTR, V99, p1235S, DOI 10.3945/ajcn.113.073015
   Banchereau J, 1998, NATURE, V392, P245, DOI 10.1038/32588
   Basu A, 2010, J NUTR, V140, P1582, DOI 10.3945/jn.110.124701
   Bedard K, 2007, PHYSIOL REV, V87, P245, DOI 10.1152/physrev.00044.2005
   Biswas SK, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/5698931
   Burdo TH, 2010, PLOS PATHOG, V6, DOI 10.1371/journal.ppat.1000842
   Cai H, 2000, CIRC RES, V87, P840, DOI 10.1161/01.RES.87.10.840
   Cai YH, 2015, J LEUKOCYTE BIOL, V97, P1147, DOI 10.1189/jlb.4A0914-441R
   Carlos Timothy M., 1994, Blood, V84, P2068
   Christ A, 2013, CIRCULATION, V128, P2603, DOI 10.1161/CIRCULATIONAHA.113.003364
   Dauer M, 2003, J IMMUNOL, V170, P4069, DOI 10.4049/jimmunol.170.8.4069
   DeFuria J, 2009, J NUTR, V139, P1510, DOI 10.3945/jn.109.105155
   Del Bo' C, 2013, NUTR RES, V33, P220, DOI 10.1016/j.nutres.2012.12.009
   DIEDERICH D, 1994, HYPERTENSION, V23, P957, DOI 10.1161/01.HYP.23.6.957
   Dizdaroglu M, 2012, CANCER LETT, V327, P26, DOI 10.1016/j.canlet.2012.01.016
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Elks CM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024028
   Faivre V, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047209
   Faria A, 2005, J AGR FOOD CHEM, V53, P6896, DOI 10.1021/jf0511300
   Freeman LR, 2013, FREE RADICAL BIO MED, V56, P226, DOI 10.1016/j.freeradbiomed.2012.08.577
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Hasegawa A, 2009, BLOOD, V114, P2917, DOI 10.1182/blood-2009-02-204263
   Italiani P, 2014, FRONT IMMUNOL, V5, DOI 10.3389/fimmu.2014.00514
   Johnson SA, 2015, J ACAD NUTR DIET, V115, P369, DOI 10.1016/j.jand.2014.11.001
   Kayserova J, 2014, CLIN IMMUNOL, V153, P49, DOI 10.1016/j.clim.2014.03.018
   Khoo Michael C K, 2013, IEEE Rev Biomed Eng, V6, P143, DOI 10.1109/RBME.2012.2232651
   Ludewig B, 1998, J EXP MED, V188, P1493, DOI 10.1084/jem.188.8.1493
   Masson GS, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0122850
   Masson GS, 2015, AM J PHYSIOL-HEART C, V309, pH1115, DOI 10.1152/ajpheart.00349.2015
   Mozaffarian D, 2015, CIRCULATION, V131, pE29, DOI 10.1161/CIR.0000000000000152
   Mykkänen OT, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0114790
   Nair AR, 2015, EXP CELL RES, V335, P238, DOI 10.1016/j.yexcr.2015.05.011
   Nair AR, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0111976
   Nair AR, 2014, FREE RADICAL BIO MED, V71, P16, DOI 10.1016/j.freeradbiomed.2014.03.012
   POBER JS, 1990, TRANSPLANTATION, V50, P537, DOI 10.1097/00007890-199010000-00001
   Rahman K, 2007, CLIN INTERV AGING, V2, P219
   Rice Beth H, 2014, Curr Nutr Rep, V3, P130
   Riso P, 2013, EUR J NUTR, V52, P949, DOI 10.1007/s00394-012-0402-9
   Rodriguez-Mateos A, 2013, AM J CLIN NUTR, V98, P1179, DOI 10.3945/ajcn.113.066639
   Sriramula S, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0138372
   Stull AJ, 2015, NUTRIENTS, V7, P4107, DOI 10.3390/nu7064107
   Stull AJ, 2010, J NUTR, V140, P1764, DOI 10.3945/jn.110.125336
   Sunderkötter C, 2004, J IMMUNOL, V172, P4410, DOI 10.4049/jimmunol.172.7.4410
   Tan JKH, 2005, J LEUKOCYTE BIOL, V78, P319, DOI 10.1189/jlb.1104664
   Van Brussel I, 2011, CLIN SCI, V120, P415, DOI 10.1042/CS20100440
   Vendrame S, 2013, J NUTR BIOCHEM, V24, P1508, DOI 10.1016/j.jnutbio.2012.12.010
   WANG P, 1995, J BIOL CHEM, V270, P9558, DOI 10.1074/jbc.270.16.9558
   Whaley-Connell A, 2011, REV CARDIOVASC MED, V12, P21, DOI 10.3909/ricm0555
   Wilson CB, 2014, BEHAV BRAIN RES, V268, P72, DOI 10.1016/j.bbr.2014.03.029
   Zellner M, 2002, WIEN KLIN WOCHENSCHR, V114, P102
   Zlotnikov-Klionsky Y, 2015, IMMUNITY, V43, P776, DOI 10.1016/j.immuni.2015.08.015
NR 53
TC 45
Z9 49
U1 0
U2 17
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD NOV
PY 2017
VL 8
IS 11
BP 4118
EP 4128
DI 10.1039/c7fo00815e
PG 11
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA FM9HW
UT WOS:000415578600027
PM 29019365
DA 2025-06-11
ER

PT J
AU Farah, D
   Nunes, J
   Sartori, M
   Dias, DD
   Sirvente, R
   Silva, MB
   Fiorino, P
   Morris, M
   Llesuy, S
   Farah, V
   Irigoyen, MC
   De Angelis, KT
AF Farah, Daniela
   Nunes, Jonas
   Sartori, Michelle
   Dias, Danielle da Silva
   Sirvente, Raquel
   Silva, Maikon B.
   Fiorino, Patricia
   Morris, Mariana
   Llesuy, Susana
   Farah, Vera
   Irigoyen, Maria-Claudia
   De Angelis, Katia
TI Exercise Training Prevents Cardiovascular Derangements Induced by
   Fructose Overload in Developing Rats
SO PLOS ONE
LA English
DT Article
ID RENIN-ANGIOTENSIN SYSTEM; OXIDATIVE STRESS; METABOLIC SYNDROME;
   BLOOD-PRESSURE; LIPID-PEROXIDATION; INSULIN-RESISTANCE;
   EXPERIMENTAL-MODEL; PHYSICAL-ACTIVITY; AUTONOMIC CONTROL; DYSFUNCTION
AB The risks of chronic diseases associated with the increasing consumption of fructose-laden foods are amplified by the lack of regular physical activity and have become a serious public health issue worldwide. Moreover, childhood eating habits are strongly related to metabolic syndrome in adults. Thus, we aimed to investigate the preventive role of exercise training undertaken concurrently with a high fructose diet on cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in male rats after weaning. Male Wistar rats were divided into 4 groups (n = 8/group):Sedentary control (SC), Trained control (TC), Sedentary Fructose (SF) and Trained Fructose (TF). Training was performed on a treadmill (8 weeks, 40-60% of maximum exercise test). Evaluations of cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in plasma and in left ventricle (LV) were performed. Chronic fructose overload induced glucose intolerance and an increase in white adipose tissue (WAT) weight, in myocardial performance index (MPI) (SF:0.42 +/- 0.04 vs. SC:0.24 +/- 0.05) and in arterial pressure (SF:122 +/- 3 vs. SC:113 +/- 1 mmHg) associated with increased cardiac and vascular sympathetic modulation. Fructose also induced unfavorable changes in oxidative stress profile (plasmatic protein oxidationSF: 3.30 +/- 0.09 vs. SC:1.45 +/- 0.08 nmol/mg prot; and LV total antioxidant capacity (TRAP)SF: 2.5 +/- 0.5 vs. SC:12.7 +/- 1.7 uM trolox). The TF group showed reduced WAT, glucose intolerance, MPI (0.35 +/- 0.04), arterial pressure (118 +/- 2mmHg), sympathetic modulation, plasmatic protein oxidation and increased TRAP when compared to SF group. Therefore, our findings indicate that cardiometabolic dysfunctions induced by fructose overload early in life may be prevented by moderate aerobic exercise training.
C1 [Farah, Daniela; Nunes, Jonas; Fiorino, Patricia; Farah, Vera] Univ Presbiteriana Mackenzie, Lab Metab Cardiovasc & Renal Physiopharmacol, Sao Paulo, Brazil.
   [Farah, Daniela; Sartori, Michelle; Sirvente, Raquel; Silva, Maikon B.; Irigoyen, Maria-Claudia] Sao Paulo Univ FMUSP, Sch Med, Lab Expt Hypertens,Heart Inst INCOR, Sao Paulo, Brazil.
   [Sartori, Michelle; Dias, Danielle da Silva; De Angelis, Katia] Univ Nove de Julho, Lab Translat Physiol, Sao Paulo, Brazil.
   [Morris, Mariana] Nova Southeastern Univ, Inst Neuro Immune Med, Ft Lauderdale, FL USA.
   [Llesuy, Susana] Univ Buenos Aires, Dept Gen & Inorgan Chem, Buenos Aires, DF, Argentina.
C3 Universidade Presbiteriana Mackenzie; Universidade de Sao Paulo;
   Universidade Nove de Julho; Nova Southeastern University; University of
   Buenos Aires
RP De Angelis, KT (corresponding author), Univ Nove de Julho, Lab Translat Physiol, Sao Paulo, Brazil.
EM kangelis@uni9.pro.br
RI da Silva Dias, Danielle/AAN-7618-2020; Farah, Vera/ABA-1171-2021; DE
   ANGELIS, KATIA/I-6098-2016; Irigoyen, maria Claudia/N-6880-2014
OI Farah, Daniela/0000-0002-9727-9460; Francisca Llesuy,
   Susana/0000-0001-6818-051X; Farah, Vera/0000-0002-5439-3079; DE ANGELIS,
   KATIA/0000-0002-3640-9049; Irigoyen, maria Claudia/0000-0003-2097-3662
FU CNPq [457200/2014-6, 309292/2014-0]; FAPESP [2015/11223-6,
   2012/01873-5]; CAPES [88881.062178/2014-01]; CNPq Fellowship (CNPq-BPQ);
   Vinnova [2012-01873] Funding Source: Vinnova
FX This study was supported by CNPq (457200/2014-6; 309292/2014-0) and
   FAPESP (2015/11223-6; 2012/01873-5); CAPES (88881.062178/2014-01). Katia
   De Angelis and Maria-Claudia Irigoyen are recipients of CNPq Fellowship
   (CNPq-BPQ). The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
CR Aebi H, 1984, Methods Enzymol, V105, P121
   ALESSIO HM, 1988, J APPL PHYSIOL, V64, P1333, DOI 10.1152/jappl.1988.64.4.1333
   Amaral SL, 2000, J HYPERTENS, V18, P1563, DOI 10.1097/00004872-200018110-00006
   Araujo IC, 2016, EUR J NUTR, V55, P83, DOI 10.1007/s00394-014-0826-5
   Bassuk SS, 2005, J APPL PHYSIOL, V99, P1193, DOI 10.1152/japplphysiol.00160.2005
   Bertagnolli M, 2006, J HYPERTENS, V24, P2437, DOI 10.1097/01.hjh.0000251905.08547.17
   Bidwell AJ, 2014, MED SCI SPORT EXER, V46, P2091, DOI 10.1249/MSS.0000000000000343
   BLAIR SN, 1989, JAMA-J AM MED ASSOC, V262, P2395, DOI 10.1001/jama.262.17.2395
   Boa BCS, 2014, MICROVASC RES, V93, P34, DOI 10.1016/j.mvr.2014.02.012
   Borovikova LV, 2000, NATURE, V405, P458, DOI 10.1038/35013070
   Bray GA, 2004, AM J CLIN NUTR, V79, P537
   Brito JO, 2008, BRAZ J MED BIOL RES, V41, P804, DOI 10.1590/S0100-879X2008005000030
   Buege J A, 1978, Methods Enzymol, V52, P302
   Camm AJ, 1996, CIRCULATION, V93, P1043
   Conti FF, 2014, BMC CARDIOVASC DISOR, V14, DOI 10.1186/1471-2261-14-185
   De Angelis K, 2012, AM J PHYSIOL-REG I, V302, pR950, DOI 10.1152/ajpregu.00450.2011
   De Angelis KLD, 2000, BRAZ J MED BIOL RES, V33, P635, DOI 10.1590/S0100-879X2000000600004
   DeAngelis KLD, 1997, HYPERTENSION, V30, P767, DOI 10.1161/01.HYP.30.3.767
   DELMAESTRO RF, 1985, CRC HDB METHODS OXYG, P294
   Duffey KJ, 2010, AM J CLIN NUTR, V92, P954, DOI 10.3945/ajcn.2010.29478
   Evelson P, 2001, ARCH BIOCHEM BIOPHYS, V388, P261, DOI 10.1006/abbi.2001.2292
   Farah V, 2006, AUTON NEUROSCI-BASIC, V130, P41, DOI 10.1016/j.autneu.2006.05.006
   Farah VMA, 2004, PHYSIOL BEHAV, V83, P135, DOI 10.1016/j.physbeh.2004.08.004
   Giacchetti G, 2000, J HYPERTENS, V18, P695, DOI 10.1097/00004872-200018060-00006
   Girard A, 2006, NUTRITION, V22, P758, DOI 10.1016/j.nut.2006.05.006
   Huston JM, 2006, J EXP MED, V203, P1623, DOI 10.1084/jem.20052362
   Janssen BJA, 2000, AM J PHYSIOL-REG I, V278, pR215, DOI 10.1152/ajpregu.2000.278.1.R215
   Kamide K, 2002, AM J HYPERTENS, V15, P66, DOI 10.1016/S0895-7061(01)02232-4
   KOKKINOS PF, 1995, NEW ENGL J MED, V333, P1462, DOI 10.1056/NEJM199511303332204
   La Rovere MT, 2002, CIRCULATION, V106, P945, DOI 10.1161/01.CIR.0000027565.12764.E1
   Lalande S, 2013, APPL PHYSIOL NUTR ME, V38, P545, DOI 10.1139/apnm-2012-0383
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   Machi JF, 2013, EUR J APPL PHYSIOL, V113, P41, DOI 10.1007/s00421-012-2411-z
   MALLIANI A, 1991, CIRCULATION, V84, P482, DOI 10.1161/01.CIR.84.2.482
   Marriott BP, 2009, J NUTR, V139, pS1228, DOI 10.3945/jn.108.098277
   MISRA HP, 1972, J BIOL CHEM, V247, P3170
   Mizuno T, 2004, INT J CARDIOL, V97, P455, DOI 10.1016/j.ijcard.2003.10.035
   Moraes-Silva IC, 2013, J APPL PHYSIOL, V114, P786, DOI 10.1152/japplphysiol.00586.2012
   Morris M, 2012, CLIN EXP PHARMACOL P, V39, P57, DOI 10.1111/j.1440-1681.2011.05636.x
   Mostarda C, 2012, CLINICS, V67, P815
   Mostarda CT, 2014, J DIABETES COMPLICAT, V28, P273, DOI 10.1016/j.jdiacomp.2013.12.005
   NEGRAO CE, 1992, J APPL PHYSIOL, V72, P1749, DOI 10.1152/jappl.1992.72.5.1749
   Nestorov J, 2014, NUTR RES, V34, P646, DOI 10.1016/j.nutres.2014.06.006
   Quinteiro H, 2015, MENOPAUSE, V22, P534, DOI [10.1097/GME.0000000000000344, 10.1097/gme.0000000000000344]
   REZNICK AZ, 1994, METHOD ENZYMOL, V233, P357
   Rodrigues B, 2007, CARDIOVASC DIABETOL, V6, DOI 10.1186/1475-2840-6-38
   Sanches IC, 2009, BRAZ J MED BIOL RES, V42, P942, DOI 10.1590/S0100-879X2009001000011
   Sanches IC, 2012, MENOPAUSE, V19, P562, DOI 10.1097/gme.0b013e3182358c9c
   Shinozaki K, 2004, HYPERTENSION, V43, P255, DOI 10.1161/01.HYP.0000111136.86976.26
   SMITH ML, 1989, MED SCI SPORT EXER, V21, P40, DOI 10.1249/00005768-198902000-00008
   Thirunavukkarasu V, 2004, DIABETES OBES METAB, V6, P200, DOI 10.1111/j.1462-8902.2004.00332.x
   Verma S, 1997, AM J HYPERTENS, V10, P1010, DOI 10.1016/S0895-7061(97)00107-6
   Wichi R, 2007, CARDIOVASC DIABETOL, V6, DOI 10.1186/1475-2840-6-14
   Xu L, 1999, HORM METAB RES, V31, P278, DOI 10.1055/s-2007-978733
NR 54
TC 18
Z9 19
U1 0
U2 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 8
PY 2016
VL 11
IS 12
AR e0167291
DI 10.1371/journal.pone.0167291
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EE4OA
UT WOS:000389580900023
PM 27930685
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Ro, SH
   Bae, J
   Jang, Y
   Myers, JF
   Chung, SK
   Yu, JJ
   Natarajan, SK
   Franco, R
   Song, HS
AF Ro, Seung-Hyun
   Bae, Jiyoung
   Jang, Yura
   Myers, Jacob F.
   Chung, Soonkyu
   Yu, Jiujiu
   Natarajan, Sathish Kumar
   Franco, Rodrigo
   Song, Hyun-Seob
TI Arsenic Toxicity on Metabolism and Autophagy in Adipose and Muscle
   Tissues
SO ANTIOXIDANTS
LA English
DT Review
DE arsenic; adipose; muscle; autophagy; oxidative stress; mitochondrial
   dysfunction; metabolism; metabolic syndrome; metabolic disease
ID STIMULATED INSULIN-SECRETION; INDUCED OXIDATIVE STRESS; SKELETAL-MUSCLE;
   DRINKING-WATER; TRIVALENT ARSENICALS; DIABETES-MELLITUS;
   LIPID-METABOLISM; UNITED-STATES; NADPH OXIDASE; EXPOSURE
AB Arsenic, a naturally occurring metalloid derived from the environment, has been studied worldwide for its causative effects in various cancers. However, the effects of arsenic toxicity on the development and progression of metabolic syndrome, including obesity and diabetes, has received less attention. Many studies suggest that metabolic dysfunction and autophagy dysregulation of adipose and muscle tissues are closely related to the development of metabolic disease. In the USA, arsenic contamination has been reported in some ground water, soil and grain samples in major agricultural regions, but the effects on adipose and muscle tissue metabolism and autophagy have not been investigated much. Here, we highlight arsenic toxicity according to the species, dose and exposure time and the effects on adipose and muscle tissue metabolism and autophagy. Historically, arsenic was used as both a poison and medicine, depending on the dose and treatment time. In the modern era, arsenic intoxication has significantly increased due to exposure from water, soil and food, which could be a contributing factor in the development and progression of metabolic disease. From this review, a better understanding of the pathogenic mechanisms by which arsenic alters metabolism and autophagy regulation could become a cornerstone leading to the development of therapeutic strategies against arsenic-induced toxicity and metabolic disease.
C1 [Ro, Seung-Hyun; Bae, Jiyoung; Jang, Yura; Myers, Jacob F.] Univ Nebraska Lincoln, Dept Biochem, Lincoln, NE 68588 USA.
   [Ro, Seung-Hyun; Bae, Jiyoung; Jang, Yura; Myers, Jacob F.] Univ Nebraska Lincoln, Redox Biol Ctr, Lincoln, NE 68588 USA.
   [Bae, Jiyoung] Univ Wisconsin, Dept Cell & Regenerat Biol, Sch Med & Publ Hlth, Madison, WI 53705 USA.
   [Jang, Yura] Johns Hopkins Univ, Inst Cell Engn, Dept Neurol, Sch Med, Baltimore, MD 21205 USA.
   [Jang, Yura] US FDA, Ctr Drug Evaluat & Res, Off Biotechnol Prod, Immunol Lab, Silver Spring, MD 20993 USA.
   [Myers, Jacob F.] Thomas Jefferson Univ, Dept Microbiol & Immunol, Sidney Kimmel Med Coll, Philadelphia, PA 19107 USA.
   [Myers, Jacob F.] Thomas Jefferson Univ, Jefferson Coll Life Sci, MD PhD Program, Philadelphia, PA 19107 USA.
   [Yu, Jiujiu; Natarajan, Sathish Kumar] Univ Nebraska Lincoln, Dept Nutr & Hlth Sci, Lincoln, NE 68583 USA.
   [Franco, Rodrigo] Univ Nebraska Lincoln, Sch Vet Med & Biomed Sci, Lincoln, NE 68583 USA.
   [Franco, Rodrigo] Univ Nebraska Lincoln, Redox Biol Ctr, Lincoln, NE 68583 USA.
   [Song, Hyun-Seob] Univ Nebraska Lincoln, Dept Biol Syst Engn, Lincoln, NE 68583 USA.
   [Song, Hyun-Seob] Univ Nebraska Lincoln, Nebraska Food Hlth Ctr, Dept Food Sci & Technol, Lincoln, NE 68588 USA.
C3 University of Nebraska System; University of Nebraska Lincoln;
   University of Nebraska System; University of Nebraska Lincoln;
   University of Wisconsin System; University of Wisconsin Madison; Johns
   Hopkins University; US Food & Drug Administration (FDA); Thomas
   Jefferson University; Thomas Jefferson University; University of
   Nebraska System; University of Nebraska Lincoln; University of Nebraska
   System; University of Nebraska Lincoln; University of Nebraska System;
   University of Nebraska Lincoln; University of Nebraska System;
   University of Nebraska Lincoln; University of Nebraska System;
   University of Nebraska Lincoln
RP Ro, SH (corresponding author), Univ Nebraska Lincoln, Dept Biochem, Lincoln, NE 68588 USA.; Ro, SH (corresponding author), Univ Nebraska Lincoln, Redox Biol Ctr, Lincoln, NE 68588 USA.
EM shro@unl.edu; jbae42@wisc.edu; abc211@hanmail.net;
   jacob.myers@students.jefferson.edu; soonkyuchung@umass.edu;
   jyu18@unl.edu; snatarajan2@unl.edu; rodrigo.franco@unl.edu;
   hsong5@unl.edu
RI Song, Hyun-Seob/IAQ-0503-2023; Bae, Jiyoung/AAL-1829-2021; Song,
   Hyun-Seob/C-4802-2018; Franco, Rodrigo/D-9470-2013
OI Natarajan, Sathish kumar/0000-0001-7491-8592; BAE,
   JIYOUNG/0000-0003-2367-7578; Song, Hyun-Seob/0000-0002-2154-6358; Myers,
   Jacob/0000-0002-2395-1576; Franco, Rodrigo/0000-0003-3241-8615
FU National Science Foundation (NSF)-REU site in the form of Training in
   Redox Biology grant [DBI-1757951]; National Institute of Health
   (NIH)/National Heart, Lung and Blood Institute (NHLBI) grant under Ruth
   L. Kirschstein National Research Service Award (NRSA) from the
   University of Wisconsin Cardiovascular Research Center [T32 HL007936];
   University of Nebraska Collaboration Initiative Team Formation and
   Publication Grant; University of Nebraska ARD/ORED/BIOC; Nebraska
   Tobacco Settlement Biomedical Research enhancement funds; Nebraska
   Center for the Prevention of Obesity Diseases (NPOD) Program Seed Grant
   from the National Institute of General Medical Sciences (NIGMS) of the
   NIH [P20 GM104320]; University of Nebraska Collaboration Initiative Team
   Seed Grant
FX This work was supported by National Science Foundation (NSF)-REU site in
   the form of Training in Redox Biology (DBI-1757951) grant to J.F.M.; the
   National Institute of Health (NIH)/National Heart, Lung and Blood
   Institute (NHLBI) grant under Ruth L. Kirschstein National Research
   Service Award (NRSA) (T32 HL007936) from the University of Wisconsin
   Cardiovascular Research Center to J.B.; the University of Nebraska
   Collaboration Initiative Team Formation and Publication Grant to S.-H.R.
   and Samuel M. Cohen; the University of Nebraska Collaboration Initiative
   Team Seed Grant to S.-H.R. and H.-S.S.; and the University of Nebraska
   ARD/ORED/BIOC grants and Nebraska Tobacco Settlement Biomedical Research
   enhancement funds to S.-H.R. and H.-S.S. This research was supported in
   part by the Nebraska Center for the Prevention of Obesity Diseases
   (NPOD) Program Seed Grant from the National Institute of General Medical
   Sciences (NIGMS) of the NIH under award number P20 GM104320.
CR Abdul KSM, 2015, ENVIRON TOXICOL PHAR, V40, P828, DOI 10.1016/j.etap.2015.09.016
   Afolabi OK, 2015, BMC PHARMACOL TOXICO, V16, DOI 10.1186/s40360-015-0015-z
   Ahmed Mahmoud, 2018, Oncotarget, V9, P15526, DOI 10.18632/oncotarget.24506
   Ajees AA, 2015, GEOMICROBIOL J, V32, P570, DOI 10.1080/01490451.2014.908983
   Ajees AA, 2012, BIOCHEMISTRY-US, V51, P5476, DOI 10.1021/bi3004632
   Ambrosio F, 2014, FREE RADICAL BIO MED, V74, P64, DOI 10.1016/j.freeradbiomed.2014.06.012
   Andersen H, 2005, DIABETIC MED, V22, P1401, DOI 10.1111/j.1464-5491.2005.01649.x
   Andersen H, 2004, DIABETES CARE, V27, P2382, DOI 10.2337/diacare.27.10.2382
   [Anonymous], 1999, ARS DRINK WAT
   Argos M, 2010, LANCET, V376, P252, DOI 10.1016/S0140-6736(10)60481-3
   Armendariz AL, 2016, PLANT PHYSIOL BIOCH, V98, P119, DOI 10.1016/j.plaphy.2015.11.021
   Athyros VG, 2018, HORM-INT J ENDOCRINO, V17, P61, DOI 10.1007/s42000-018-0014-8
   Au W. Y., 2011, Hong Kong Medical Journal, V17, P507
   Ayotte JD, 2017, ENVIRON SCI TECHNOL, V51, P12443, DOI 10.1021/acs.est.7b02881
   Azad MB, 2009, ANTIOXID REDOX SIGN, V11, P777, DOI [10.1089/ars.2008.2270, 10.1089/ARS.2008.2270]
   Bae J, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-50965-9
   Baerga R, 2009, AUTOPHAGY, V5, P1118, DOI 10.4161/auto.5.8.9991
   Bessho M, 2013, CARDIOVASC TOXICOL, V13, P267, DOI 10.1007/s12012-013-9206-2
   Bjorklund G, 2020, ARCH TOXICOL, V94, P1879, DOI 10.1007/s00204-020-02739-w
   Blanco AEC, 2021, J AGR FOOD CHEM, V69, P2287, DOI 10.1021/acs.jafc.0c06853
   Blasiak J, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21144994
   Bräuner EV, 2014, ENVIRON HEALTH PERSP, V122, P1059, DOI 10.1289/ehp.1408198
   Carlin DJ, 2016, ENVIRON HEALTH PERSP, V124, P890, DOI 10.1289/ehp.1510209
   Carlson P, 2014, AQUAT TOXICOL, V153, P66, DOI 10.1016/j.aquatox.2013.10.006
   Castriota F, 2018, ENVIRON RES, V167, P248, DOI 10.1016/j.envres.2018.07.022
   Chen CM, 2020, MOLECULES, V25, DOI 10.3390/molecules25133057
   Chen H, 2004, CARCINOGENESIS, V25, P1779, DOI 10.1093/carcin/bgh161
   Chen J, 2020, FRONT ENV SCI-SWITZ, V8, DOI 10.3389/fenvs.2020.00043
   Cheng TJ, 2011, TOXICOL APPL PHARM, V256, P146, DOI 10.1016/j.taap.2011.08.001
   Chi L, 2019, ENVIRON HEALTH PERSP, V127, DOI 10.1289/EHP4415
   Chiesa LM, 2019, FOOD ADDIT CONTAM A, V36, P1228, DOI 10.1080/19440049.2019.1619944
   Chiu CY, 2020, TOXICOL IN VITRO, V65, DOI 10.1016/j.tiv.2020.104829
   Cohen S, 1989, GROUNDW MONIT REMEDI, V9, P57, DOI [10.1111/j.1745-6592.1989.tb01010.x, DOI 10.1111/J.1745-6592.1989.TB01010.X]
   CRANE RK, 1953, J BIOL CHEM, V201, P235
   D'Souza DM, 2013, FRONT PHYSIOL, V4, DOI 10.3389/fphys.2013.00379
   Diaz-Villaseñor A, 2007, TOXICOL APPL PHARM, V225, P123, DOI 10.1016/j.taap.2007.08.019
   Divya SP, 2015, TOXICOL SCI, V146, P290, DOI 10.1093/toxsci/kfv089
   Dodson M, 2018, MOL CELL BIOL, V38, DOI 10.1128/MCB.00595-17
   Douillet C, 2013, TOXICOL APPL PHARM, V267, P11, DOI 10.1016/j.taap.2012.12.007
   Dover EN, 2018, ARCH TOXICOL, V92, P693, DOI 10.1007/s00204-017-2074-y
   Drobna Z., 2009, CURRENT PROTOCOLS TO, p4.31. 1
   Drobná Z, 2010, ARCH TOXICOL, V84, P3, DOI 10.1007/s00204-009-0499-7
   Farkhondeh T, 2019, J CELL PHYSIOL, V234, P12516, DOI 10.1002/jcp.28112
   Farzad R, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0217043
   Fisher AT, 2017, J PUBLIC HEALTH POL, V38, P395, DOI 10.1057/s41271-017-0087-7
   Fricke M, 2007, ANAL CHIM ACTA, V583, P78, DOI 10.1016/j.aca.2006.09.048
   Galluzzi L, 2017, EMBO J, V36, P1811, DOI 10.15252/embj.201796697
   Galluzzi L, 2014, CELL, V159, P1263, DOI 10.1016/j.cell.2014.11.006
   Garciafigueroa DY, 2013, TOXICOL SCI, V134, P335, DOI 10.1093/toxsci/kft108
   Gosselin David C., 2006, Great Plains Research, V16, P137
   Herath I, 2018, ENVIRON INT, V115, P370, DOI 10.1016/j.envint.2018.03.027
   Hilton TN, 2008, PHYS THER, V88, P1336, DOI 10.2522/ptj.20080079
   Hong GM, 2012, TOXICOL SCI, V129, P146, DOI 10.1093/toxsci/kfs186
   Hosseini MJ, 2013, IRAN J PHARM RES, V12, P119
   Hou YY, 2013, ENVIRON HEALTH PERSP, V121, P237, DOI 10.1289/ehp.1205731
   Huang SY, 1998, BRIT J HAEMATOL, V103, P1092, DOI 10.1046/j.1365-2141.1998.01079.x
   Hughes MF, 2002, TOXICOL LETT, V133, P1, DOI 10.1016/S0378-4274(02)00084-X
   Hughes MF, 2006, ENVIRON HEALTH PERSP, V114, P1790, DOI 10.1289/ehp.9058
   Jensen TJ, 2009, TOXICOL APPL PHARM, V241, P221, DOI 10.1016/j.taap.2009.08.019
   Jiao JQ, 2017, CURR OPIN PHARMACOL, V34, P1, DOI 10.1016/j.coph.2017.03.009
   Jomova K, 2011, J APPL TOXICOL, V31, P95, DOI 10.1002/jat.1649
   Kala SV, 2000, J BIOL CHEM, V275, P33404, DOI 10.1074/jbc.M007030200
   Karagas Margaret R, 2015, Curr Environ Health Rep, V2, P52, DOI 10.1007/s40572-014-0040-x
   Khairul I, 2017, ONCOTARGET, V8, P23905, DOI 10.18632/oncotarget.14733
   Kim DD, 2016, VALUE HEALTH, V19, P602, DOI 10.1016/j.jval.2016.02.008
   Kitchin KT, 2001, TOXICOL APPL PHARM, V172, P249, DOI 10.1006/taap.2001.9157
   Kleiman NJ, 2016, J TOXICOL ENV HEAL A, V79, P339, DOI 10.1080/15287394.2016.1151392
   Klein CB, 2007, TOXICOL APPL PHARM, V222, P289, DOI 10.1016/j.taap.2006.12.033
   Kloska A, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21176113
   Kosacka J, 2015, MOL CELL ENDOCRINOL, V409, P21, DOI 10.1016/j.mce.2015.03.015
   Kovsan J, 2011, J CLIN ENDOCR METAB, V96, pE268, DOI 10.1210/jc.2010-1681
   Kuivenhoven M., 2021, Arsenic Toxicity
   Kuo CC, 2018, ENVIRON INT, V118, P97, DOI 10.1016/j.envint.2018.05.033
   Kuo CC, 2017, ENVIRON HEALTH PERSP, V125, DOI 10.1289/EHP577
   LANSDOWN ABG, 1995, CRIT REV TOXICOL, V25, P397, DOI 10.3109/10408449509049339
   Latowski A.K.a.D, 2016, MOL BIOPHY BIOCH, V1, P9, DOI [10.15761/MBB.1000103, DOI 10.15761/MBB.1000103]
   Lau A, 2013, MOL CELL BIOL, V33, P2436, DOI 10.1128/MCB.01748-12
   Levine B, 2008, CELL, V132, P27, DOI 10.1016/j.cell.2007.12.018
   Levine B, 2017, P NATL ACAD SCI USA, V114, P201, DOI 10.1073/pnas.1619876114
   Liu J, 2008, J PHARMACOL EXP THER, V326, P363, DOI 10.1124/jpet.108.139543
   Liu ZJ, 2006, ENVIRON HEALTH PERSP, V114, P527, DOI 10.1289/ehp.8600
   Marette A, 2014, REV ENDOCR METAB DIS, V15, P299, DOI 10.1007/s11154-014-9296-6
   Martinez VD, 2011, J TOXICOL-US, V2011, DOI 10.1155/2011/431287
   Maull EA, 2012, ENVIRON HEALTH PERSP, V120, P1658, DOI 10.1289/ehp.1104579
   Mazumder DNG, 2001, J TOXICOL-CLIN TOXIC, V39, P665, DOI 10.1081/CLT-100108507
   McDowell HE, 1997, EUR J BIOCHEM, V247, P306, DOI 10.1111/j.1432-1033.1997.00306.x
   Meliker JR, 2007, ENVIRON HEALTH-GLOB, V6, DOI 10.1186/1476-069X-6-4
   Mizushima N, 2008, NATURE, V451, P1069, DOI 10.1038/nature06639
   Mizushima N, 2011, CELL, V147, P728, DOI 10.1016/j.cell.2011.10.026
   Moon KA, 2017, INT J EPIDEMIOL, V46, P1924, DOI 10.1093/ije/dyx202
   Naranmandura H, 2011, CHEM RES TOXICOL, V24, P1586, DOI 10.1021/tx200291p
   Naujokas MF, 2013, ENVIRON HEALTH PERSP, V121, P295, DOI 10.1289/ehp.1205875
   Navas-Acien A, 2006, ENVIRON HEALTH PERSP, V114, P641, DOI 10.1289/ehp.8551
   Navas-Acien A, 2008, JAMA-J AM MED ASSOC, V300, P814, DOI 10.1001/jama.300.7.814
   NDA, 2020, NEBR DEP AGR REP
   Noda NN, 2015, ANNU REV BIOPHYS, V44, P101, DOI 10.1146/annurev-biophys-060414-034248
   Nurchi VM, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10020235
   Pallauf K, 2013, AGEING RES REV, V12, P237, DOI 10.1016/j.arr.2012.03.008
   Palma-Lara I, 2020, REGUL TOXICOL PHARM, V110, DOI 10.1016/j.yrtph.2019.104539
   Parsons JG, 2008, CHEMOSPHERE, V70, P2076, DOI 10.1016/j.chemosphere.2007.08.069
   Partridge MA, 2007, CANCER RES, V67, P5239, DOI 10.1158/0008-5472.CAN-07-0074
   Paul DS, 2007, TOXICOL APPL PHARM, V222, P305, DOI 10.1016/j.taap.2007.01.010
   Pei J, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16050757
   Petrick JS, 2001, CHEM RES TOXICOL, V14, P651, DOI 10.1021/tx000264z
   Planer-Friedrich B, 2007, ENVIRON SCI TECHNOL, V41, P5245, DOI 10.1021/es070273v
   Prakash C, 2016, BIOL TRACE ELEM RES, V173, P87, DOI 10.1007/s12011-016-0622-6
   Preston SH, 2018, P NATL ACAD SCI USA, V115, P957, DOI 10.1073/pnas.1716802115
   Rabinowitz JD, 2010, SCIENCE, V330, P1344, DOI 10.1126/science.1193497
   Ramanathan K, 2003, J NUTR BIOCHEM, V14, P416, DOI 10.1016/S0955-2863(03)00076-7
   Ratnaike RN, 2003, POSTGRAD MED J, V79, P391, DOI 10.1136/pmj.79.933.391
   Ravenscroft B.H., 2009, ARSENIC POLLUTION GL
   Rehman MYA, 2022, ENVIRON POLLUT, V292, DOI 10.1016/j.envpol.2021.118279
   Reichard JF, 2007, BIOCHEM BIOPH RES CO, V352, P188, DOI 10.1016/j.bbrc.2006.11.001
   Renu K, 2018, TOXICOL LETT, V284, P86, DOI 10.1016/j.toxlet.2017.11.032
   Rivas-Santiago C, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/4978018
   Ro SH, 2018, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00022
   Roy NK, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10091351
   Rubin SSCD, 2014, ENVIRON HEALTH PERSP, V122, P817, DOI 10.1289/ehp.1307759
   Salazard B, 2004, CELL BIOL TOXICOL, V20, P375, DOI 10.1007/s10565-004-1471-1
   Samanta G, 2004, SCI TOTAL ENVIRON, V326, P33, DOI 10.1016/j.scitotenv.2003.12.006
   Sarker MK, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18189730
   SCOTT N, 1993, CHEM RES TOXICOL, V6, P102, DOI 10.1021/tx00031a016
   Shao K, 2021, TOXICOLOGY, V455, DOI 10.1016/j.tox.2021.152752
   Sidhu MS, 2015, TOXICOLOGY, V331, P78, DOI 10.1016/j.tox.2015.02.008
   Smith KR, 2001, AM J PHYSIOL-LUNG C, V280, pL442, DOI 10.1152/ajplung.2001.280.3.L442
   Song XB, 2017, BIOL TRACE ELEM RES, V179, P140, DOI 10.1007/s12011-017-0950-1
   Soni M, 2018, APPL BIOCHEM BIOTECH, V186, P27, DOI 10.1007/s12010-018-2723-5
   Soussi H, 2015, DIABETES, V64, P3452, DOI 10.2337/db14-1933
   Spratlen MJ, 2018, AM J EPIDEMIOL, V187, P1598, DOI 10.1093/aje/kwy048
   Steinmaus C, 2009, EPIDEMIOLOGY, V20, P807, DOI 10.1097/EDE.0b013e3181b0fd29
   Straub AC, 2008, J CLIN INVEST, V118, P3980, DOI 10.1172/JCI35092
   Sun YZ, 2016, J ENVIRON SCI, V49, P59, DOI 10.1016/j.jes.2016.08.016
   Szymkowicz DB, 2018, AQUAT TOXICOL, V198, P276, DOI 10.1016/j.aquatox.2018.03.015
   Trouba KJ, 2000, TOXICOL APPL PHARM, V168, P25, DOI 10.1006/taap.2000.9012
   Uddin AN, 2005, CARCINOGENESIS, V26, P2179, DOI 10.1093/carcin/bgi180
   Vahidnia A, 2007, HUM EXP TOXICOL, V26, P823, DOI 10.1177/0960327107084539
   Walton FS, 2004, TOXICOL APPL PHARM, V198, P424, DOI 10.1016/j.taap.2003.10.026
   Wang JJ, 2020, NAT GEOSCI, V13, P282, DOI 10.1038/s41561-020-0533-1
   Wang YC, 2011, LANCET, V378, P815, DOI 10.1016/S0140-6736(11)60814-3
   Wang Y, 2018, J INORG BIOCHEM, V188, P1, DOI 10.1016/j.jinorgbio.2018.08.001
   Wang Y, 2018, CHEMOSPHERE, V206, P597, DOI 10.1016/j.chemosphere.2018.05.013
   Wang ZX, 2005, CELL RES, V15, P379, DOI 10.1038/sj.cr.7290305
   Wauson EM, 2002, TOXICOL SCI, V65, P211, DOI 10.1093/toxsci/65.2.211
   Waxman S, 2001, ONCOLOGIST, V6, P3, DOI 10.1634/theoncologist.6-suppl_2-3
   Wells GD, 2008, CAN J NEUROL SCI, V35, P31, DOI 10.1017/S0317167100007538
   Yang L, 2019, INT J BIOCHEM CELL B, V112, P50, DOI 10.1016/j.biocel.2019.05.001
   Zhang CQ, 2016, STEM CELLS, V34, P732, DOI 10.1002/stem.2232
   Zhang Y, 2012, PHARMACOL RES, V66, P505, DOI 10.1016/j.phrs.2012.09.004
   Zuo Z, 2019, SCI TOTAL ENVIRON, V668, P310, DOI 10.1016/j.scitotenv.2019.03.008
NR 149
TC 10
Z9 11
U1 1
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD APR
PY 2022
VL 11
IS 4
AR 689
DI 10.3390/antiox11040689
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 0S1LA
UT WOS:000786041900001
PM 35453374
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Oltman, CL
   Richou, LL
   Davidson, EP
   Coppey, LJ
   Lund, DD
   Yorek, MA
AF Oltman, Christine L.
   Richou, Laura L.
   Davidson, Eric P.
   Coppey, Lawrence J.
   Lund, Donald D.
   Yorek, Mark A.
TI Progression of coronary and mesenteric vascular dysfunction in Zucker
   obese and Zucker diabetic fatty rats
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE metabolic syndrome; Type 2 diabetes; oxidative stress; acetylcholine
ID NERVE CONDUCTION-VELOCITY; ENDONEURIAL BLOOD-FLOW; EPINEURIAL
   ARTERIOLES; ARACHIDONIC-ACID; OXIDANT STRESS; SCIATIC-NERVE; REACTIVITY;
   VASODILATION; INSULIN; MECHANISM
AB We investigated the progression of vascular dysfunction associated with the metabolic syndrome with and without hyperglycemia in lean, Zucker obese, and Zucker diabetic fatty (ZDF) rats. Responses of aorta and small coronary and mesenteric arteries were measured to endothelium-dependent and -independent vasodilators. Indices of oxidative stress were increased in serum from ZDF rats throughout the study, whereas values were increased in Zucker obese rats later in the study [thiobarbituric acid reactive substances: 0.45 +/- 0.02, 0.59 +/- 0.03 (P < 0.05), and 0.58 +/- 0.03 (P < 0.05) mu g/ml in serum from 28- to 40-wk-old lean, Zucker obese, and ZDF rats, respectively]. Acetylcholine (ACh)-induced relaxation was not altered in vessels from lean animals from 8-40 wk. ACh-induced relaxation was nearly abolished in coronary arteries from 28 to 36-wk-old Zucker obese rats and by 16-36 wk in ZDF rats and was attenuated in aorta and mesenteric vessels from ZDF rats [%relaxation to 10 mu M ACh: 72.2 +/- 7.1, 17.9 +/- 5.9 (P < 0.05), and 23.0 +/- 4.5 (P < 0.05) in coronary vessels; and 67.9 +/- 9.2, 50.1 +/- 5.5, and 42.3 +/- 4.7 (P < 0.05) in mesenteric vessels from 28- to 40-wk-old lean, Zucker obese, and ZDF rats, respectively]. The attenuated ACh-induced relaxation was improved when vessels were incubated with tiron, suggesting superoxide as a mechanism of endothelial dysfunction. Sodium nitroprusside-induced relaxation was not altered in aorta or coronary arteries and was potentiated in mesenteric arteries from Zucker obese rats. Our data suggest that diabetes enhances the progression of vascular dysfunction. Increases in indices of oxidative stress precede the development of dysfunction and may serve as a marker of endothelial damage.
C1 Iowa Dept Vet Affairs, Iowa City, IA USA.
   Univ Iowa, Coll Med, Dept Internal Med, Iowa City, IA 52242 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Iowa City VA Health Care System; University of Iowa
RP Oltman, CL (corresponding author), VA Med Ctr, Rm 204,Bld 40,Highway 6 W, Iowa City, IA 52246 USA.
EM christine-oltman@uiowa.edu
RI Yorek, Mark/AAC-3136-2021
OI Yorek, Mark/0000-0001-7737-5554
CR Amos A F, 1997, Diabet Med, V14 Suppl 5, pS1
   Arvola P, 1999, CARDIOVASC RES, V43, P992, DOI 10.1016/S0008-6363(99)00141-8
   Brandes RP, 2000, HYPERTENSION, V35, P231, DOI 10.1161/01.HYP.35.1.231
   Coppey LJ, 2002, DIABETES-METAB RES, V18, P49, DOI 10.1002/dmrr.257
   Coppey LJ, 2001, DIABETES, V50, P1927, DOI 10.2337/diabetes.50.8.1927
   Erdös B, 2004, DIABETES, V53, P1352, DOI 10.2337/diabetes.53.5.1352
   Frisbee JC, 2002, AM J PHYSIOL-HEART C, V283, pH2160, DOI 10.1152/ajpheart.00379.2002
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Katakam PVG, 2005, AM J PHYSIOL-HEART C, V288, pH854, DOI 10.1152/ajpheart.00715.2004
   MIHARA M, 1980, BIOCHEM MED METAB B, V23, P302, DOI 10.1016/0006-2944(80)90040-X
   MONCADA S, 1991, P NATL ACAD SCI USA, V88, P2166, DOI 10.1073/pnas.88.6.2166
   Okon EB, 2003, J VASC RES, V40, P520, DOI 10.1159/000075238
   Oltman CL, 1997, CARDIOVASC RES, V34, P179, DOI 10.1016/S0008-6363(97)00016-3
   Oltman CL, 2000, AM J PHYSIOL-ENDOC M, V279, pE176, DOI 10.1152/ajpendo.2000.279.1.E176
   Oltman CL, 2005, AM J PHYSIOL-ENDOC M, V289, pE113, DOI 10.1152/ajpendo.00594.2004
   Oltman CL, 2003, AM J PHYSIOL-HEART C, V285, pH2309, DOI 10.1152/ajpheart.00456.2003
   Oltman CL, 2001, AM J PHYSIOL-HEART C, V281, pH1553, DOI 10.1152/ajpheart.2001.281.4.H1553
   Peterson R.G., 1990, ILAR NEWS, V32, P16, DOI DOI 10.1093/ILAR.32.3.16
   Phillips SA, 2005, AM J PHYSIOL-REG I, V288, pR522, DOI 10.1152/ajpregu.00655.2004
   Romanko OP, 2005, AM J PHYSIOL-HEART C, V289, pH2097, DOI 10.1152/ajpheart.00213.2005
   Siman CM, 1997, DIABETOLOGIA, V40, P1416, DOI 10.1007/s001250050844
   Sparks JD, 2000, METABOLISM, V49, P1424, DOI 10.1053/meta.2000.17736
   Stepp DW, 2002, AM J PHYSIOL-HEART C, V282, pH816, DOI 10.1152/ajpheart.00695.2001
   Subramanian R, 2003, EUR J PHARMACOL, V477, P143, DOI 10.1016/j.ejphar.2003.08.003
   Zhang CX, 2004, DIABETES, V53, P2950, DOI 10.2337/diabetes.53.11.2950
NR 25
TC 117
Z9 130
U1 0
U2 2
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD OCT
PY 2006
VL 291
IS 4
BP H1780
EP H1787
DI 10.1152/ajpheart.01297.2005
PG 8
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 084CP
UT WOS:000240509700035
PM 16714356
DA 2025-06-11
ER

PT J
AU Dokras, A
AF Dokras, Anuja
TI Noncontraceptive use of oral combined hormonal contraceptives in
   polycystic ovary syndrome-risks versus benefits
SO FERTILITY AND STERILITY
LA English
DT Review
DE Polycystic ovary syndrome; hormonal contraceptives; lipids; metabolic
   syndrome
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; ANDROGEN EXCESS; CANCER-RISK;
   FLUTAMIDE-METFORMIN; CYPROTERONE-ACETATE; ENDOMETRIAL CANCER;
   INSULIN-RESISTANCE; ETHINYL ESTRADIOL; BREAST-CANCER
AB The use of steroid sex hormones for noncontraceptive benefits has been endorsed by several medical societies. In women with polycystic ovary syndrome (PCOS), hormonal contraceptives are first-line therapy for concurrent treatment of menstrual irregularity, acne, and hirsutism. The association of PCOS with obesity, diabetes, and dyslipidemia frequently brings up the debate regarding risks versus benefits of hormonal contraceptives in this population. In women with PCOS, the lack of large-scale studies evaluating the risks with varying doses of ethinyl estradiol, types of progestins, and presence of confounding factors such as obesity, smoking, and other cardiometabolic comorbidities is a significant limitation in these deliberations. Although it is important to assess the absolute risk for major morbidities including cardiovascular events, currently, there are a paucity of long-term data for these outcomes in PCOS. Most of the current studies do not suggest an increase in risk of prediabetes/diabetes, clinically significant dyslipidemia, inflammatory changes, or depressive/anxiety symptoms with oral contraceptive pill use. Screening of women with PCOS for cardiometabolic and psychiatric comorbidities is routinely recommended. This information should be used by health care providers to individualize the choice of hormonal contraceptive treatment, adequately counsel patients regarding risks and benefits, and formulate an appropriate follow-up plan. (C) 2016 by American Society for Reproductive Medicine.
C1 [Dokras, Anuja] Univ Penn, Dept Obstet & Gynecol, 3701 Market St, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania
RP Dokras, A (corresponding author), Univ Penn, Dept Obstet & Gynecol, 3701 Market St, Philadelphia, PA 19104 USA.
EM adokras@obgyn.upenn.edu
CR [Anonymous], 2010, Medical eligibility criteria for contraceptive use, V4th
   [Anonymous], 2016, US MED ELIGIBILITY C
   [Anonymous], COCHRANE DATABASE SY
   [Anonymous], CONTRACEPTION
   Archer JS, 2004, BEST PRACT RES CL OB, V18, P737, DOI 10.1016/j.bpobgyn.2004.05.007
   Aydin K, 2013, CONTRACEPTION, V87, P358, DOI 10.1016/j.contraception.2012.07.005
   Baird DT, 2005, HUM REPROD UPDATE, V11, P513, DOI 10.1093/humupd/dmi019
   BALL MJ, 1990, CONTRACEPTION, V41, P363, DOI 10.1016/0010-7824(90)90036-U
   Barry JA, 2014, HUM REPROD UPDATE, V20, P748, DOI 10.1093/humupd/dmu012
   Barter PJ, 2007, NEW ENGL J MED, V357, P2109, DOI 10.1056/NEJMoa0706628
   Battaglia C, 2010, FERTIL STERIL, V94, P1417, DOI 10.1016/j.fertnstert.2009.05.044
   Bhattacharya SM, 2012, FERTIL STERIL, V98, P1053, DOI 10.1016/j.fertnstert.2012.06.035
   Bird ST, 2013, CAN MED ASSOC J, V185, pE115, DOI 10.1503/cmaj.120677
   Carmina E, 2007, J CLIN ENDOCR METAB, V92, P2500, DOI 10.1210/jc.2006-2725
   ChasanTaber L, 1997, DIABETES CARE, V20, P330, DOI 10.2337/diacare.20.3.330
   Chittenden BG, 2009, REPROD BIOMED ONLINE, V19, P398, DOI 10.1016/S1472-6483(10)60175-7
   Christakou C, 2014, HORM-INT J ENDOCRINO, V13, P488, DOI 10.14310/horm.2002.1553
   Cinar N, 2012, HUM REPROD, V27, P1840, DOI 10.1093/humrep/des113
   Corbould A, 2008, DIABETES-METAB RES, V24, P520, DOI 10.1002/dmrr.872
   de Bastos M, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010813.pub2
   Díaz M, 2012, J CLIN ENDOCR METAB, V97, P3630, DOI 10.1210/jc.2012-1754
   Dieudonné MN, 1998, AM J PHYSIOL-CELL PH, V274, pC1645, DOI 10.1152/ajpcell.1998.274.6.C1645
   Dokras A, 2005, OBSTET GYNECOL, V106, P131, DOI 10.1097/01.AOG.0000167408.30893.6b
   Dokras A, 2016, J CLIN ENDOCR METAB, V101, P2966, DOI 10.1210/jc.2016-1896
   Dokras A, 2013, STEROIDS, V78, P773, DOI 10.1016/j.steroids.2013.04.009
   Dokras A, 2012, FERTIL STERIL, V97, P225, DOI 10.1016/j.fertnstert.2011.10.022
   Dokras A, 2011, OBSTET GYNECOL, V117, P145, DOI 10.1097/AOG.0b013e318202b0a4
   Dumesic DA, 2013, STEROIDS, V78, P782, DOI 10.1016/j.steroids.2013.04.004
   Escobar-Morreale HF, 2011, FERTIL STERIL, V95, P1048, DOI 10.1016/j.fertnstert.2010.11.036
   Fauser BCJM, 2012, FERTIL STERIL, V97, P28, DOI 10.1016/j.fertnstert.2011.09.024
   Gallo MF, 2014, COCHRANE DB SYST REV, V29
   Glintborg D, 2014, J ENDOCRINOL INVEST, V37, P757, DOI 10.1007/s40618-014-0103-8
   Goodman NF, 2015, ENDOCR PRACT, V21, P1291, DOI 10.4158/EP15748.DSC
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Halperin IJ, 2011, HUM REPROD, V26, P191, DOI 10.1093/humrep/deq301
   Hannaford PC, 2007, BRIT MED J, V335, P651, DOI 10.1136/bmj.39289.649410.55
   Haoula Z, 2012, HUM REPROD, V27, P1327, DOI 10.1093/humrep/des042
   Harris-Glocker M, 2010, FERTIL STERIL, V93, P1016, DOI 10.1016/j.fertnstert.2009.08.006
   Ibáñez L, 2004, J CLIN ENDOCR METAB, V89, P1592, DOI 10.1210/jc.2003-031281
   Ibánez L, 2013, J CLIN ENDOCR METAB, V98, pE902, DOI 10.1210/jc.2013-1041
   Khera AV, 2013, J AM COLL CARDIOL, V62, P1909, DOI 10.1016/j.jacc.2013.07.025
   Krintus M, 2010, CLIN BIOCHEM, V43, P626, DOI 10.1016/j.clinbiochem.2009.12.013
   Kriplani A, 2010, CONTRACEPTION, V82, P139, DOI 10.1016/j.contraception.2010.02.009
   Lara-Castro C, 2006, DIABETES, V55, P249, DOI 10.2337/diabetes.55.01.06.db05-1105
   Legro RS, 2008, J CLIN ENDOCR METAB, V93, P420, DOI 10.1210/jc.2007-2287
   Legro RS, 2015, J CLIN ENDOCR METAB, V100, P4048, DOI 10.1210/jc.2015-2778
   Lidegaard O, 2012, NEW ENGL J MED, V366, P2257, DOI 10.1056/NEJMoa1111840
   Lim SS, 2013, OBES REV, V14, P95, DOI 10.1111/j.1467-789X.2012.01053.x
   Lopez LM, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006133.pub5
   Martin KA, 2008, J CLIN ENDOCR METAB, V93, P1105, DOI 10.1210/jc.2007-2437
   Mendoza N, 2014, GYNECOL ENDOCRINOL, V30, P850, DOI 10.3109/09513590.2014.943725
   Moran LJ, 2010, J ENDOCRINOL INVEST, V33, P258, DOI [10.1007/BF03345790, 10.3275/6563]
   Moran LJ, 2010, HUM REPROD UPDATE, V16, P347, DOI 10.1093/humupd/dmq001
   Navaratnarajah R, 2008, SEMIN REPROD MED, V26, P62, DOI 10.1055/s-2007-992926
   Okoroh EM, 2012, AM J OBSTET GYNECOL, V207, DOI 10.1016/j.ajog.2012.08.007
   Orio F, 2016, CLIN ENDOCRINOL, V85, P764, DOI 10.1111/cen.13112
   Panidis D, 2012, HUM REPROD, V27, P541, DOI 10.1093/humrep/der418
   Puder JJ, 2005, J CLIN ENDOCR METAB, V90, P6014, DOI 10.1210/jc.2005-1002
   RIMM EB, 1992, DIABETOLOGIA, V35, P967, DOI 10.1007/BF00401427
   Schlesselman JJ, 1997, HUM REPROD, V12, P1851, DOI 10.1093/humrep/12.9.1851
   Shen CC, 2015, ONCOLOGIST, V20, P45, DOI 10.1634/theoncologist.2014-0311
   Sitruk-Ware R., 2016, FERTIL STERIL
   Soini T, 2014, OBSTET GYNECOL, V124, P292, DOI 10.1097/AOG.0000000000000356
   Thomson RL, 2010, FERTIL STERIL, V94, P1812, DOI 10.1016/j.fertnstert.2009.11.001
   Toulis KA, 2009, HUM REPROD UPDATE, V15, P297, DOI 10.1093/humupd/dmp006
   van de Woestijne AP, 2011, OBES REV, V12, P829, DOI 10.1111/j.1467-789X.2011.00900.x
   van Rooijen M, 2006, J THROMB HAEMOST, V4, P77, DOI 10.1111/j.1538-7836.2005.01690.x
   van Rooijen M, 2002, AM J OBSTET GYNECOL, V186, P44, DOI 10.1067/mob.2002.119179
   Vessey M, 2006, BRIT J CANCER, V95, P385, DOI 10.1038/sj.bjc.6603260
   Virtue S, 2010, BBA-MOL CELL BIOL L, V1801, P338, DOI 10.1016/j.bbalip.2009.12.006
   Vrbíková J, 2005, HUM REPROD UPDATE, V11, P277, DOI 10.1093/humupd/dmi005
   WALSH BW, 1991, NEW ENGL J MED, V325, P1196, DOI 10.1056/NEJM199110243251702
   Wannamethee SG, 2005, ARCH INTERN MED, V165, P2644, DOI 10.1001/archinte.165.22.2644
   WATANABE RM, 1994, J CLIN ENDOCR METAB, V79, P1277, DOI 10.1210/jc.79.5.1277
   Wild RA, 2011, FERTIL STERIL, V95, P1073, DOI 10.1016/j.fertnstert.2010.12.027
   Wild RA, 2010, J CLIN ENDOCR METAB, V95, P2038, DOI 10.1210/jc.2009-2724
   Yildiz BO, 2015, J CLIN ENDOCR METAB, V100, P794, DOI 10.1210/jc.2014-3196
   Zegro RS, 2013, J CLIN ENDOCR METAB, V98, P4565
NR 78
TC 19
Z9 21
U1 0
U2 36
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0015-0282
EI 1556-5653
J9 FERTIL STERIL
JI Fertil. Steril.
PD DEC
PY 2016
VL 106
IS 7
BP 1572
EP 1579
DI 10.1016/j.fertnstert.2016.10.027
PG 8
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA EF9RU
UT WOS:000390668400006
PM 27817838
OA Bronze
DA 2025-06-11
ER

PT J
AU Eichers, ER
   Abd-El-Barr, MM
   Paylor, R
   Lewis, RA
   Bi, WM
   Lin, XD
   Meehan, TP
   Stockton, DW
   Wu, SM
   Lindsay, E
   Justice, MJ
   Beales, PL
   Katsanis, N
   Lupski, JR
AF Eichers, Erica R.
   Abd-El-Barr, Muhammad M.
   Paylor, Richard
   Lewis, Richard Alan
   Bi, Weimin
   Lin, Xiaodi
   Meehan, Thomas P.
   Stockton, David W.
   Wu, Samuel M.
   Lindsay, Elizabeth
   Justice, Monica J.
   Beales, Philip L.
   Katsanis, Nicholas
   Lupski, James R.
TI Phenotypic characterization of Bbs4 null mice reveals
   age-dependent penetrance and variable expressivity
SO HUMAN GENETICS
LA English
DT Article
ID BARDET-BIEDL-SYNDROME; MCKUSICK-KAUFMAN-SYNDROME; BEHAVIORAL-TEST
   BATTERIES; HUMAN OBESITY SYNDROME; TRIALLELIC INHERITANCE; METABOLIC
   SYNDROME; KNOCKOUT MICE; SYNDROME GENE; MOUSE MODELS; MUTATIONS
AB Bardet-Biedl syndrome (BBS) is a rare oligogenic disorder exhibiting both clinical and genetic heterogeneity. Although the BBS phenotype is variable both between and within families, the syndrome is characterized by the hallmarks of developmental and learning difficulties, post-axial polydactylia, obesity, hypogenitalism, renal abnormalities, retinal dystrophy, and several less frequently observed features. Eleven genes mutated in BBS patients have been identified, and more are expected to exist, since about 20-30% of all families cannot be explained by the known loci. To investigate the etiopathogenesis of BBS, we created a mouse null for one of the murine homologues, Bbs4, to assess the contribution of one gene to the pleiotropic murine Bbs phenotype. Bbs4 null mice, although initially runted compared to their littermates, ultimately become obese in a gender-dependent manner, females earlier and with more severity than males. Blood chemistry tests indicated abnormal lipid profiles, signs of liver dysfunction, and elevated insulin and leptin levels reminiscent of metabolic syndrome. As in patients with BBS, we found age-dependent retinal dystrophy. Behavioral assessment revealed that mutant mice displayed more anxiety-related responses and reduced social dominance. We noted the rare occurrence of birth defects, including neural tube defects and hydrometrocolpos, in the null mice. Evaluations of these null mice have uncovered phenotypic features with age-dependent penetrance and variable expressivity, partially recapitulating the human BBS phenotype.
C1 Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
   Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA.
   Baylor Coll Med, Dept Ophthalmol, Houston, TX 77030 USA.
   Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA.
   Baylor Coll Med, Dept Med, Houston, TX 77030 USA.
   Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA.
   Texas Childrens Hosp, Houston, TX 77030 USA.
   UCL, Inst Child Hlth, Mol Med Unit, London WC1N 1EH, England.
   Johns Hopkins Univ, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA.
   Johns Hopkins Univ, Wilmer Eye Inst, Baltimore, MD 21205 USA.
C3 Baylor College of Medicine; Baylor College of Medicine; Baylor College
   of Medicine; Baylor College of Medicine; Baylor College of Medicine;
   Baylor College of Medicine; Baylor College of Medicine; Baylor College
   Medical Hospital; University of London; University College London; Johns
   Hopkins University; Johns Hopkins University; Johns Hopkins Medicine
RP Lupski, JR (corresponding author), Baylor Coll Med, Dept Mol & Human Genet, 1 Baylor Pl Room 604B, Houston, TX 77030 USA.
EM jlupski@bcm.edu
RI Katsanis, Nicholas/E-1837-2012; Beales, Philip/C-7367-2009
OI Abd-El-Barr, Muhammad/0000-0001-7151-2861; Katsanis,
   Nicholas/0000-0002-2480-0171
FU Medical Research Council [G0801843] Funding Source: Medline; NEI NIH HHS
   [EY02520, R01 EY016859, EY0446] Funding Source: Medline; NICHD NIH HHS
   [R01 HD42601, U01 HD39372] Funding Source: Medline; NIDDK NIH HHS [R01
   DK072301] Funding Source: Medline; Wellcome Trust Funding Source:
   Medline
CR Ansley SJ, 2003, NATURE, V425, P628, DOI 10.1038/nature02030
   Badano JL, 2006, NATURE, V439, P326, DOI 10.1038/nature04370
   Badano JL, 2003, HUM MOL GENET, V12, P1651, DOI 10.1093/hmg/ddg188
   Badano JL, 2003, AM J HUM GENET, V72, P650, DOI 10.1086/368204
   Barnett S, 2002, J Med Genet, V39, pe76, DOI 10.1136/jmg.39.12.e76
   Beales PL, 1999, J MED GENET, V36, P437
   Beales PL, 2003, AM J HUM GENET, V72, P1187, DOI 10.1086/375178
   BERSON EL, 1968, ARCH OPHTHALMOL-CHIC, V80, P68
   Bouwknecht J. Adriaan, 2002, Behavioural Brain Research, V136, P489, DOI 10.1016/S0166-4328(02)00200-0
   Bramblett DE, 2004, NEURON, V43, P779, DOI 10.1016/j.neuron.2004.08.032
   Chiang AP, 2006, P NATL ACAD SCI USA, V103, P6287, DOI 10.1073/pnas.0600158103
   Chiang AP, 2004, AM J HUM GENET, V75, P475, DOI 10.1086/423903
   COPPER AJ, 1976, BIOL NEONATE, V29, P56
   COPPOLA DM, 1994, PHYSIOL BEHAV, V56, P729, DOI 10.1016/0031-9384(94)90234-8
   CRAIGEN WJ, 2001, METABOLIC MOL BASES, V1, P379
   Crawley JN, 1997, HORM BEHAV, V31, P197, DOI 10.1006/hbeh.1997.1382
   David A, 1999, J MED GENET, V36, P599
   DEKABAN AS, 1969, J GENET HUM, V17, P289
   DELANEY V, 1978, Q J MED, V47, P281
   EDWARDS DA, 1972, BEHAV BIOL, V7, P823, DOI 10.1016/S0091-6773(72)80174-3
   Eichers ER, 2004, ANN MED, V36, P262, DOI 10.1080/07853890410026214
   Fan YL, 2004, NAT GENET, V36, P989, DOI 10.1038/ng1414
   Fath MA, 2005, HUM MOL GENET, V14, P1109, DOI 10.1093/hmg/ddi123
   Franks PW, 2005, OBES RES, V13, P1476, DOI 10.1038/oby.2005.178
   GREEN JS, 1989, NEW ENGL J MED, V321, P1002, DOI 10.1056/NEJM198910123211503
   Héon E, 2005, AM J MED GENET A, V132A, P283, DOI 10.1002/ajmg.a.30466
   Hongo T, 2000, BIOL NEONATE, V78, P293, DOI 10.1159/000014282
   Hood DC, 1996, J OPT SOC AM A, V13, P623, DOI 10.1364/JOSAA.13.000623
   Iannello S, 2002, Obes Rev, V3, P123, DOI 10.1046/j.1467-789X.2002.00055.x
   JACOBSON SG, 1990, AM J OPHTHALMOL, V109, P676, DOI 10.1016/S0002-9394(14)72436-5
   Jawién J, 2004, J PHYSIOL PHARMACOL, V55, P503
   Katsanis N, 2001, SCIENCE, V293, P2256, DOI 10.1126/science.1063525
   Katsanis N, 2002, AM J HUM GENET, V71, P22, DOI 10.1086/341031
   Katsanis N, 2000, NAT GENET, V26, P67, DOI 10.1038/79201
   Kim JC, 2004, NAT GENET, V36, P462, DOI 10.1038/ng1352
   Kulaga HM, 2004, NAT GENET, V36, P994, DOI 10.1038/ng1418
   LAVY T, 1995, J PEDIATR OPHTHALMOL, V32, P364
   Li JB, 2004, CELL, V117, P541, DOI 10.1016/S0092-8674(04)00450-7
   Liebenauer LL, 1996, PHYSIOL BEHAV, V60, P403, DOI 10.1016/S0031-9384(96)80011-4
   McIlwain KL, 2001, PHYSIOL BEHAV, V73, P705, DOI 10.1016/S0031-9384(01)00528-5
   MCKUSICK VA, 1964, JAMA-J AM MED ASSOC, V189, P813
   MEEKER WR, 1971, AM J SURG, V122, P822, DOI 10.1016/0002-9610(71)90454-5
   Mehrotra N, 1997, AM J MED GENET, V69, P220, DOI 10.1002/(SICI)1096-8628(19970317)69:2<220::AID-AJMG21>3.0.CO;2-M
   Mykytyn K, 2004, P NATL ACAD SCI USA, V101, P8664, DOI 10.1073/pnas.0402354101
   Mykytyn K, 2002, NAT GENET, V31, P435, DOI 10.1038/ng935
   Mykytyn K, 2001, NAT GENET, V28, P188, DOI 10.1038/88925
   Nishimura DY, 2005, AM J HUM GENET, V77, P1021, DOI 10.1086/498323
   Nishimura DY, 2004, P NATL ACAD SCI USA, V101, P16588, DOI 10.1073/pnas.0405496101
   Nishimura DY, 2001, HUM MOL GENET, V10, P865, DOI 10.1093/hmg/10.8.865
   PAGON RA, 1982, AM J MED GENET, V13, P373, DOI 10.1002/ajmg.1320130405
   Paylor R, 2006, PHYSIOL BEHAV, V87, P95, DOI 10.1016/j.physbeh.2005.09.002
   Pennesi ME, 2003, P NATL ACAD SCI USA, V100, P6783, DOI 10.1073/pnas.1130102100
   Pepperberg DR, 1997, VISUAL NEUROSCI, V14, P73, DOI 10.1017/S0952523800008774
   Proesmans W, 1975, Clin Nephrol, V3, P160
   Riise R, 1996, ACTA OPHTHALMOL SCAN, V74, P618, DOI 10.1111/j.1600-0420.1996.tb00747.x
   Riise R, 1996, ACTA OPHTHALMOL SCAN, V74, P612, DOI 10.1111/j.1600-0420.1996.tb00746.x
   RIZZO JF, 1986, OPHTHALMOLOGY, V93, P1452
   Ross AJ, 2005, NAT GENET, V37, P1135, DOI 10.1038/ng1644
   ROSS CF, 1956, J PATHOL BACTERIOL, V72, P161, DOI 10.1002/path.1700720122
   Schaap C, 1998, EUR J PEDIATR, V157, P170
   Shawkat FS, 1996, EYE, V10, P53, DOI 10.1038/eye.1996.8
   Slavotinek AM, 2000, NAT GENET, V26, P15, DOI 10.1038/79116
   Spencer CM, 2005, GENES BRAIN BEHAV, V4, P420, DOI 10.1111/j.1601-183X.2005.00123.x
   Stoetzel C, 2006, NAT GENET, V38, P521, DOI 10.1038/ng1771
   STOLER JM, 1995, AM J MED GENET, V55, P276, DOI 10.1002/ajmg.1320550306
   Stone DL, 2000, NAT GENET, V25, P79, DOI 10.1038/75637
   TEICHER MH, 1978, PHYSIOL BEHAV, V21, P553, DOI 10.1016/0031-9384(78)90130-0
   TSUCHIYA R, 1977, ARCH SURG-CHICAGO, V112, P82
   Walz K, 2004, HUM MOL GENET, V13, P367, DOI 10.1093/hmg/ddh044
   Zimmet P, 1999, ANN NY ACAD SCI, V892, P25, DOI 10.1111/j.1749-6632.1999.tb07783.x
NR 70
TC 87
Z9 104
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0340-6717
J9 HUM GENET
JI Hum. Genet.
PD SEP
PY 2006
VL 120
IS 2
BP 211
EP 226
DI 10.1007/s00439-006-0197-y
PG 16
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA 073GF
UT WOS:000239730300008
PM 16794820
DA 2025-06-11
ER

PT J
AU Santamaría, R
   Díaz-Tocados, JM
   de Mier, MVPR
   Robles, A
   Salmerón-Rodríguez, MD
   Ruiz, E
   Vergara, N
   Aguilera-Tejero, E
   Raya, A
   Ortega, R
   Felsenfeld, A
   Muñoz-Castañeda, JR
   Martín-Malo, A
   Aljama, P
   Rodríguez, M
AF Santamaria, Rafael
   Diaz-Tocados, Juan M.
   Pendon-Ruiz de Mier, M. Victoria
   Robles, Ana
   Dolores Salmeron-Rodriguez, M.
   Ruiz, Erena
   Vergara, Noemi
   Aguilera-Tejero, Escolastico
   Raya, Ana
   Ortega, Rosa
   Felsenfeld, Arnold
   Munoz-Castaneda, Juan R.
   Martin-Malo, Alejandro
   Aljama, Pedro
   Rodriguez, Mariano
TI Increased Phosphaturia Accelerates The Decline in Renal Function: A
   Search for Mechanisms
SO SCIENTIFIC REPORTS
LA English
DT Article
ID CHRONIC KIDNEY-DISEASE; MORTALITY; DIETARY; PHOSPHORUS; METABOLISM;
   TOXICITY; RISK
AB In chronic kidney disease (CKD), high serum phosphate concentration is associated with cardiovascular disease and deterioration in renal function. In early CKD, the serum phosphate concentration is normal due to increased fractional excretion of phosphate. Our premise was that high phosphate intake even in patients with early CKD would result in an excessive load of phosphate causing tubular injury and accelerating renal function deterioration. In CKD 2-3 patients, we evaluated whether increased phosphaturia accelerates CKD progression. To have a uniform group of patients with early CKD, 95 patients with metabolic syndrome without overt proteinuria were followed for 2.7 +/- 1.6 years. The median decline in eGFR was 0.50 ml/min/1.73m(2)/year. Patients with a more rapid decrease in eGFR had greater phosphaturia. Moreover, the rate of decrease in eGFR inversely correlated with the degree of phosphaturia. Additionally, phosphaturia independently predicted renal function deterioration. In heminephrectomized rats, a high phosphate diet increased phosphaturia resulting in renal tubular damage associated with inflammation, oxidative stress and low klotho expression. Moreover, in rats with hyperphosphatemia and metabolic syndrome antioxidant treatment resulted in attenuation of renal lesions. In HEK-293 cells, high phosphate promoted oxidative stress while melatonin administration reduced ROS generation. Our findings suggest that phosphate loading in early CKD, results in renal damage and a more rapid decrease in renal function due to renal tubular injury.
C1 [Santamaria, Rafael; Pendon-Ruiz de Mier, M. Victoria; Robles, Ana; Dolores Salmeron-Rodriguez, M.; Ruiz, Erena; Vergara, Noemi; Munoz-Castaneda, Juan R.; Martin-Malo, Alejandro; Aljama, Pedro; Rodriguez, Mariano] Reina Sofia Univ Hosp, Serv Nephrol, Cordoba, Spain.
   [Santamaria, Rafael; Diaz-Tocados, Juan M.; Pendon-Ruiz de Mier, M. Victoria; Dolores Salmeron-Rodriguez, M.; Ruiz, Erena; Vergara, Noemi; Aguilera-Tejero, Escolastico; Raya, Ana; Munoz-Castaneda, Juan R.; Martin-Malo, Alejandro; Aljama, Pedro; Rodriguez, Mariano] Maimonides Biomed Res Inst Cordoba IMIBIC, Res Unit, Cordoba, Spain.
   [Santamaria, Rafael; Diaz-Tocados, Juan M.; Pendon-Ruiz de Mier, M. Victoria; Dolores Salmeron-Rodriguez, M.; Ruiz, Erena; Vergara, Noemi; Aguilera-Tejero, Escolastico; Raya, Ana; Munoz-Castaneda, Juan R.; Martin-Malo, Alejandro; Aljama, Pedro; Rodriguez, Mariano] Univ Cordoba, Cordoba, Spain.
   [Ortega, Rosa] Reina Sofia Univ Hosp, Dept Pathol, Cordoba, Spain.
   [Felsenfeld, Arnold] Univ Calif Los Angeles, Serv Nephrol, West Los Angeles VA, Los Angeles, CA USA.
   [Santamaria, Rafael; Martin-Malo, Alejandro; Aljama, Pedro; Rodriguez, Mariano] ISCIII, Red Invest Renal RedInRen, Madrid, Spain.
   [Santamaria, Rafael; Martin-Malo, Alejandro; Aljama, Pedro; Rodriguez, Mariano] EUTOX, Madrid, Spain.
C3 Hospital Universitario Reina Sofia - Cordoba; Universidad de Cordoba;
   Hospital Universitario Reina Sofia - Cordoba; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); West Los Angeles VA
   Medical Center; University of California System; University of
   California Los Angeles; Instituto de Salud Carlos III
RP Muñoz-Castañeda, JR (corresponding author), Reina Sofia Univ Hosp, Serv Nephrol, Cordoba, Spain.; Muñoz-Castañeda, JR (corresponding author), Maimonides Biomed Res Inst Cordoba IMIBIC, Res Unit, Cordoba, Spain.; Muñoz-Castañeda, JR (corresponding author), Univ Cordoba, Cordoba, Spain.
RI Santamaria, Rafael/P-5819-2019; Segarra, Ana/C-6219-2017;
   Muñoz-Castañeda, Juan/AFQ-3443-2022; Díaz Tocados, Juan/I-8254-2018;
   Raya, Ana/A-9548-2017
OI Munoz-Castaneda, Juan R/0000-0002-9341-0724; Raya Bermudez, Ana
   Isabel/0000-0002-4489-9447; Rodriguez, Mariano/0000-0002-9380-6614;
   Santamaria, Rafael/0000-0002-2627-1445; Diaz Tocados, Juan
   Miguel/0000-0001-5192-5212
FU Spanish Government Grant from Programa Nacional I + D + I 2008-2011 from
   Instituto de Salud Carlos III [PI14/00638, PI14/00467]; European Funds
   (FEDER); Consejeria de Economia, Innovacion, Ciencia y Empleo from the
   Junta de Andalucia [CVI-7925]; REDINREN from Instituto de Salud Carlos
   III (ISCIII); EUTOX; Junta de Andalucia [PI-0311-2014]; EUTOX
   [PI12/01866]; Nicolas Monardes Programme, Consejeria de Salud-SAS (Junta
   de Andalucia)
FX This work has been partially supported by a Spanish Government Grant
   from the Programa Nacional I + D + I 2008-2011 from the Instituto de
   Salud Carlos III (PI14/00638 and PI14/00467) with co-financing from
   European Funds (FEDER), Consejeria de Economia, Innovacion, Ciencia y
   Empleo from the Junta de Andalucia (CVI-7925) and REDINREN from
   Instituto de Salud Carlos III (ISCIII) and EUTOX. This work was also
   supported by PI-0311-2014 Junta de Andalucia and PI12/01866 and EUTOX.
   JR Munoz-Castaneda is a senior researcher supported by the Nicolas
   Monardes Programme, Consejeria de Salud-SAS (Junta de Andalucia).
CR Block GA, 2004, J AM SOC NEPHROL, V15, P2208, DOI 10.1097/01.ASN.0000133041.27682.A2
   Block GA, 2013, AM J KIDNEY DIS, V62, P457, DOI 10.1053/j.ajkd.2013.03.042
   Dhingra R, 2007, ARCH INTERN MED, V167, P879, DOI 10.1001/archinte.167.9.879
   Di Iorio BR, 2013, NEPHROL DIAL TRANSPL, V28, P632, DOI 10.1093/ndt/gfs477
   HAUT LL, 1980, KIDNEY INT, V17, P722, DOI 10.1038/ki.1980.85
   Isakova T, 2011, JAMA-J AM MED ASSOC, V305, P2432, DOI 10.1001/jama.2011.826
   Kestenbaum B, 2007, SEMIN DIALYSIS, V20, P286, DOI 10.1111/j.1525-139X.2007.00303.x
   Levey AS, 2009, ANN INTERN MED, V150, P604, DOI 10.7326/0003-4819-150-9-200905050-00006
   Loniewski I, 2014, KIDNEY INT, V85, P529, DOI 10.1038/ki.2013.401
   Martin KJ, 2011, CLIN J AM SOC NEPHRO, V6, P440, DOI 10.2215/CJN.05130610
   Martínez-Moreno JM, 2017, CLIN SCI, V131, P1449, DOI 10.1042/CS20160807
   Moe SM., 2017, Kidney Int, V76, pS1, DOI DOI 10.1038/KI.2009.188
   Muñoz-Castañeda JR, 2017, FASEB J, V31, P3858, DOI 10.1096/fj.201700006R
   Ohnishi M, 2010, FASEB J, V24, P3562, DOI 10.1096/fj.09-152488
   Rodriguez-Benot A, 2005, AM J KIDNEY DIS, V46, P68, DOI 10.1053/j.ajkd.2005.04.006
   Sakaguchi Y, 2015, KIDNEY INT, V88, P833, DOI 10.1038/ki.2015.165
   Selamet U, 2016, KIDNEY INT, V89, P176, DOI 10.1038/ki.2015.284
   Sherman RA, 2007, SEMIN DIALYSIS, V20, P16, DOI 10.1111/j.1525-139X.2007.00204.x
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Uribarri J, 2013, ANN NY ACAD SCI, V1301, P11, DOI 10.1111/nyas.12201
   Zhou D, 2017, J AM SOC NEPHROL, V28, P2322, DOI 10.1681/ASN.2016080902
NR 21
TC 39
Z9 40
U1 0
U2 9
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 12
PY 2018
VL 8
AR 13701
DI 10.1038/s41598-018-32065-2
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GT3CK
UT WOS:000444377500021
PM 30209259
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Radman, M
   McGuire, J
   Zimmerman, J
AF Radman, Monique
   McGuire, John
   Zimmerman, Jerry
TI Childhood Obesity, Endothelial Cell Activation, and Critical Illness
SO FRONTIERS IN PEDIATRICS
LA English
DT Review
DE obesity; endothelial; activation; dysfunction; critical illness;
   inflammation; pediatric
ID CARDIOVASCULAR RISK-FACTORS; NITRIC-OXIDE SYNTHASE; BODY-MASS INDEX;
   METABOLIC SYNDROME; OXIDATIVE STRESS; PROGENITOR CELLS; SUBLINGUAL
   MICROCIRCULATION; CARDIOPULMONARY BYPASS; ADHESION MOLECULES; EXERCISE
   CAPACITY
AB Pediatric obesity is increasing in prevalence and is frequently an antecedent to adult obesity and adult obesity-associated morbidities such as atherosclerosis, type II diabetes, and chronic metabolic syndrome. Endothelial cell activation, one aspect of inflammation, is present in the early stages of atherosclerosis, often prior to the onset of symptoms. Endothelial activation is a pathological condition in which vasoconstricting, pro-thrombotic, and proliferative mediators predominate protective vasodilating, anti-thrombogenic, and anti-mitogenic mediators. Many studies report poor outcomes among obese children with systemic endothelial activation. Likewise, the link between childhood obesity and poor outcomes in critical illness is well-established. However, the link between obesity and severity of endothelial activation specifically in the setting of critical illness is largely unstudied. Although endothelial cell activation is believed to worsen disease in critically ill children, the nature and extent of this response is poorly understood due to the difficulty in measuring endothelial cell dysfunction and destruction. Based on the data available for the obese, asymptomatic population and the obese, critically ill population, the authors posit that obesity, and obesity-associated chronic inflammation, including oxidative stress and insulin resistance, may contribute to endothelial activation and associated worse outcomes among critically ill children. A research agenda to examine this hypothesis is suggested.
C1 [Radman, Monique; McGuire, John; Zimmerman, Jerry] Univ Washington, Seattle Childrens Hosp, Pediat Crit Care, Seattle, WA 98195 USA.
C3 University of Washington; University of Washington Seattle; Seattle
   Children's Hospital
RP Radman, M (corresponding author), Univ Washington, Seattle Childrens Hosp, Pediat Crit Care, Seattle, WA 98195 USA.
EM monique.radman@seattlechildrens.org
RI Radman, Monique/JEP-5684-2023
FU Seattle Children's Hospital Department of Critical Care Medicine and
   Seattle Children's Research Institute Indirect Cost Return Allocation
FX Open access publication fees provided by the Seattle Children's Hospital
   Department of Critical Care Medicine and Seattle Children's Research
   Institute Indirect Cost Return Allocation.
CR Adawi M, 2019, QJM-INT J MED, V112, P161, DOI 10.1093/qjmed/hcy204
   Aicher A, 2003, NAT MED, V9, P1370, DOI 10.1038/nm948
   Aird WC, 2003, BLOOD, V101, P3765, DOI 10.1182/blood-2002-06-1887
   Alaedeen DI, 2006, J PEDIATR SURG, V41, P239, DOI 10.1016/j.jpedsurg.2005.10.045
   ANDERSON TJ, 1995, NEW ENGL J MED, V332, P488, DOI 10.1056/NEJM199502233320802
   [Anonymous], 2011, Pediatrics, V128, pS213, DOI [DOI 10.1542/peds.2009-2107C, 10.1542/peds.2009-2107C, DOI 10.1542/PEDS.2009-2107C]
   Bark BP, 2013, CRIT CARE MED, V41, P857, DOI 10.1097/CCM.0b013e318274157e
   Barr FE, 2003, J PEDIATR-US, V142, P26, DOI 10.1067/mpd.2003.mpd0311
   Barr FE, 2007, J THORAC CARDIOV SUR, V134, P319, DOI 10.1016/j.jtcvs.2007.02.043
   Beuk RJ, 2000, ANN SURG, V231, P96, DOI 10.1097/00000658-200001000-00014
   Bonetti PO, 2003, EUR HEART J, V24, P225, DOI 10.1016/S0195-668X(02)00419-0
   Boura-Halfon S, 2009, AM J PHYSIOL-ENDOC M, V296, pE581, DOI 10.1152/ajpendo.90437.2008
   Boyle EM, 1996, ANN THORAC SURG, V62, P1868, DOI 10.1016/S0003-4975(96)00950-2
   Boyle EM, 1996, ANN THORAC SURG, V62, P1549, DOI 10.1016/0003-4975(96)00836-3
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Burnier M, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0848-0
   Carroll CL, 2006, PEDIATR CRIT CARE ME, V7, P527, DOI 10.1097/01.PCC.0000243749.14555.E8
   CELERMAJER DS, 1992, LANCET, V340, P1111, DOI 10.1016/0140-6736(92)93147-F
   Cohen MS, 2010, AM HEART J, V160, P1092, DOI 10.1016/j.ahj.2010.07.039
   Caixeta DMD, 2013, CLINICS, V68, P1061, DOI 10.6061/clinics/2013(07)26
   da Silva MR, 2020, PHYSIOL BEHAV, V213, DOI 10.1016/j.physbeh.2019.112728
   Deanfield JE, 2007, CIRCULATION, V115, P1285, DOI 10.1161/CIRCULATIONAHA.106.652859
   Dimmeler S, 1996, FEBS LETT, V399, P71, DOI 10.1016/S0014-5793(96)01289-6
   Dupuis J, 1999, CIRCULATION, V99, P3227, DOI 10.1161/01.CIR.99.25.3227
   Evans JL, 2002, ENDOCR REV, V23, P599, DOI 10.1210/er.2001-0039
   Fernández-Sarmiento J, 2020, PEDIATR CRIT CARE ME, V21, pE291, DOI 10.1097/PCC.0000000000002266
   Flammer AJ, 2012, CIRCULATION, V126, P753, DOI 10.1161/CIRCULATIONAHA.112.093245
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   Förstermann U, 2006, CIRCULATION, V113, P1708, DOI 10.1161/CIRCULATIONAHA.105.602532
   García-Cardeña G, 2000, ANN NY ACAD SCI, V902, P294
   Ghosh S, 2002, CELL, V109, pS81, DOI 10.1016/S0092-8674(02)00703-1
   Gimbrone MA, 1999, AM J PATHOL, V155, P1, DOI 10.1016/S0002-9440(10)65090-0
   Giordano P, 2017, INT J CARDIOL, V228, P621, DOI 10.1016/j.ijcard.2016.11.025
   Glowinska-Olszewska B, 2007, J PEDIATR ENDOCR MET, V20, P1125, DOI 10.1515/JPEM.2007.20.10.1125
   Goldberg DJ, 2020, CIRCULATION, V141, P641, DOI 10.1161/CIRCULATIONAHA.119.044352
   Goldstein BH, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.116.004258
   Goldstein BH, 2011, AM J CARDIOL, V108, P428, DOI 10.1016/j.amjcard.2011.03.064
   Goldstein BH, 2010, AM J CARDIOL, V105, P1169, DOI 10.1016/j.amjcard.2009.12.020
   Govers R, 2001, AM J PHYSIOL-RENAL, V280, pF193, DOI 10.1152/ajprenal.2001.280.2.F193
   Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
   Griendling KK, 2000, CIRC RES, V86, P494, DOI 10.1161/01.RES.86.5.494
   Hannon TS, 2006, PEDIATR RES, V60, P759, DOI 10.1203/01.pdr.0000246097.73031.27
   Hazelzet JA, 1998, INFECT IMMUN, V66, P5350, DOI 10.1128/IAI.66.11.5350-5356.1998
   Hoffman TM, 2003, CIRCULATION, V107, P996, DOI 10.1161/01.CIR.0000051365.81920.28
   Järvisalo MJ, 2002, ARTERIOSCL THROM VAS, V22, P1323, DOI 10.1161/01.ATV.0000024222.06463.21
   Job KM, 2016, ANESTH ANALG, V123, P382, DOI 10.1213/ANE.0000000000001284
   John S, 1998, CIRCULATION, V98, P211, DOI 10.1161/01.CIR.98.3.211
   Juonala M, 2011, NEW ENGL J MED, V365, P1876, DOI 10.1056/NEJMoa1010112
   Kapiotis S, 2006, ARTERIOSCL THROM VAS, V26, P2541, DOI 10.1161/01.ATV.0000245795.08139.70
   Karnik S, 2012, INT J PREVENTIVE MED, V3, P1
   Kelly AS, 2007, METABOLISM, V56, P1005, DOI 10.1016/j.metabol.2007.03.009
   Krueger M, 2007, INTENS CARE MED, V33, P359, DOI 10.1007/s00134-006-0453-6
   Kuboki K, 2000, CIRCULATION, V101, P676, DOI 10.1161/01.CIR.101.6.676
   Kuiper JW, 2016, CRIT CARE, V20, DOI 10.1186/s13054-016-1496-x
   KUPINSKI AM, 1993, AM J PHYSIOL, V264, pH901, DOI 10.1152/ajpheart.1993.264.3.H901
   Kurose I, 1997, AM J PHYSIOL-HEART C, V272, pH2976, DOI 10.1152/ajpheart.1997.272.6.H2976
   Kyle UG, 2012, JPEN-PARENTER ENTER, V36, P177, DOI 10.1177/0148607111415108
   Laufs U, 2004, CIRCULATION, V109, P220, DOI 10.1161/01.CIR.0000109141.48980.37
   Long E, 2018, PEDIATR CRIT CARE ME, V19, P513, DOI 10.1097/PCC.0000000000001534
   López M, 2012, AIDS REV, V14, P223
   Maitoza LA, 2020, PEDIATR CRIT CARE ME, V21, P373, DOI 10.1097/PCC.0000000000002201
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Mallat Z, 2000, CIRCULATION, V101, P841, DOI 10.1161/01.CIR.101.8.841
   Mauras N, 2010, J CLIN ENDOCR METAB, V95, P1060, DOI 10.1210/jc.2009-1887
   McCrindle BW, 2007, ARCH DIS CHILD, V92, P509, DOI 10.1136/adc.2006.105239
   Meyer AA, 2006, J AM COLL CARDIOL, V48, P1865, DOI 10.1016/j.jacc.2006.07.035
   Moncada S, 2002, NAT REV MOL CELL BIO, V3, P214, DOI 10.1038/nrm762
   MONCADA S, 1977, LANCET, V1, P18
   Monostori P, 2010, EUR J PEDIATR, V169, P1369, DOI 10.1007/s00431-010-1234-3
   Montero D, 2012, OBES REV, V13, P441, DOI 10.1111/j.1467-789X.2011.00956.x
   Mulivor AW, 2004, AM J PHYSIOL-HEART C, V286, pH1672, DOI 10.1152/ajpheart.00832.2003
   Murphy ECS, 2009, INT J PEDIATR OBES, V4, P205, DOI 10.3109/17477160902846187
   Nadel S, 2007, LANCET, V369, P836, DOI 10.1016/S0140-6736(07)60411-5
   Nafiu OO, 2007, PEDIATR ANESTH, V17, P426, DOI 10.1111/j.1460-9592.2006.02140.x
   Nakamura T, 2010, CELL, V140, P338, DOI 10.1016/j.cell.2010.01.001
   Ogden CL, 2012, JAMA-J AM MED ASSOC, V307, P483, DOI [10.1001/jama.2012.39, 10.1001/jama.2012.40]
   OLIVER MG, 1991, INFLAMMATION, V15, P331, DOI 10.1007/BF00917350
   Op den Buijs J, 2004, AM J PHYSIOL-HEART C, V287, pH2651, DOI 10.1152/ajpheart.00332.2004
   Oragui EE, 2000, CRIT CARE MED, V28, P3002, DOI 10.1097/00003246-200008000-00054
   Paize F, 2012, INTENS CARE MED, V38, P863, DOI 10.1007/s00134-012-2476-5
   Pérez-Navero JL, 2009, AN PEDIATR, V70, P424, DOI 10.1016/j.anpedi.2009.01.019
   Pickkers P, 2005, SHOCK, V24, P508, DOI 10.1097/01.shk.0000190827.36406.6e
   Pierce RW, 2017, PEDIATRICS, V140, DOI 10.1542/peds.2017-0355
   Reitsma S, 2007, PFLUG ARCH EUR J PHY, V454, P345, DOI 10.1007/s00424-007-0212-8
   Rhee SG, 2006, SCIENCE, V312, P1882, DOI 10.1126/science.1130481
   Rossano JW, 2007, J HEART LUNG TRANSPL, V26, P718, DOI 10.1016/j.healun.2007.05.001
   Saghizadeh M, 1996, J CLIN INVEST, V97, P1111, DOI 10.1172/JCI118504
   Schächinger V, 2000, Z KARDIOL, V89, P70
   Schlager O, 2011, VASC MED, V16, P97, DOI 10.1177/1358863X11400780
   Skillman HE, 2008, JPEN-PARENTER ENTER, V32, P520, DOI 10.1177/0148607108322398
   Solinas G, 2010, FASEB J, V24, P2596, DOI 10.1096/fj.09-151340
   Song JW, 2017, J PHARMACOL EXP THER, V361, P115, DOI 10.1124/jpet.116.239509
   Spiekermann S, 2003, CIRCULATION, V107, P1383, DOI 10.1161/01.CIR.0000056762.69302.46
   Srinivasan V, 2010, PEDIATRICS, V125, pE481, DOI 10.1542/peds.2009-1324
   Stofkova Andrea, 2019, Bioelectron Med, V5, P14, DOI 10.1186/s42234-019-0030-2
   Sudano I, 2010, SWISS MED WKLY, V140, P139, DOI [10.4414/smw.2010.13122, smw-12966]
   Tinken TM, 2010, HYPERTENSION, V55, P312, DOI 10.1161/HYPERTENSIONAHA.109.146282
   Tjonna AE, 2009, CLIN SCI, V116, P317, DOI 10.1042/CS20080249
   TREASURE CB, 1995, NEW ENGL J MED, V332, P481, DOI 10.1056/NEJM199502233320801
   Uzark K, 2008, PEDIATRICS, V121, pE1060, DOI 10.1542/peds.2006-3778
   van Ierssel SH, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/985813
   Vasa M, 2001, CIRC RES, V89, pE1, DOI 10.1161/hh1301.093953
   Verrier ED, 1998, ANN THORAC SURG, V66, pS17, DOI 10.1016/S0003-4975(98)00965-5
   Virdis A, 2010, PFLUG ARCH EUR J PHY, V459, P1015, DOI 10.1007/s00424-009-0783-7
   Walter DH, 2002, AM J CARDIOL, V89, P1, DOI 10.1016/S0002-9149(01)02153-1
   Wassmann S, 2001, HYPERTENSION, V37, P1450, DOI 10.1161/01.HYP.37.6.1450
   Watts K, 2004, J PEDIATR-US, V144, P620, DOI 10.1016/j.jpeds.2004.02.027
   Wellnitz K, 2015, EUR J CLIN NUTR, V69, P1105, DOI 10.1038/ejcn.2015.68
   Whalen MJ, 2000, CRIT CARE MED, V28, P2600, DOI 10.1097/00003246-200007000-00070
   Whitney JE, 2020, CRIT CARE MED, V48, P344, DOI 10.1097/CCM.0000000000004091
   Wilson PWF, 2005, CIRCULATION, V112, P3066, DOI 10.1161/CIRCULATIONAHA.105.539528
   Woywodt A, 2002, NEPHROL DIAL TRANSPL, V17, P1728, DOI 10.1093/ndt/17.10.1728
   Zeng Y, 2014, AM J PHYSIOL-HEART C, V306, pH363, DOI 10.1152/ajpheart.00687.2013
NR 113
TC 7
Z9 7
U1 0
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-2360
J9 FRONT PEDIATR
JI Front. Pediatr.
PD AUG 5
PY 2020
VL 8
AR 441
DI 10.3389/fped.2020.00441
PG 9
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA NF4PW
UT WOS:000563280900001
PM 32850554
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU De Couck, M
   Mravec, B
   Gidron, Y
AF De Couck, Marijke
   Mravec, Boris
   Gidron, Yori
TI You may need the vagus nerve to understand pathophysiology and to treat
   diseases
SO CLINICAL SCIENCE
LA English
DT Article
DE Alzheimer's disease; cancer; cardiovascular disease; heart rate
   variability; neuromodulation; vagus nerve
ID HEART-RATE-VARIABILITY; C-REACTIVE PROTEIN; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; DAMAGE; RISK;
   ATHEROSCLEROSIS; STIMULATION; MODULATION
AB Can different pathophysiological mechanisms and risk factors leading to various diseases be linked with altered transmission of signals by one common pathway? The present article provides evidence for the hypothesis that adequate vagal nerve activity reduces the risk of major diseases, via common basic mechanisms and interim risk factors. These diseases include cardiovascular disease, cancer, Alzheimer's disease and the metabolic syndrome. Three basic mechanisms contribute to such illnesses: local oxidative stress and DNA damage, inflammatory reactions and excessive sympathetic responses, all of which are inhibited by vagal nerve activity. Efferent vagal activity that can be non-invasively measured by HRV (heart rate variability), derived from an ECG, is inversely related to all three basic mechanisms, to various risk factors (e.g. diabetes and dyslipidaemia) and, more broadly, to the diseases as well. Finally, vagal activity is proposed to moderate the effects of risk factors on developing such illnesses. By proposing an integrative neurobiological model of major diseases, identifying people at risk for, and treating patients with, such diseases may be done more efficiently. People with low HRV may be identified and subsequently treated by vagus nerve activation to possibly prevent or treat such illnesses. This proposed disease paradigm may have important preventative and therapeutic implications, whose clinical effects need to be investigated.
C1 [De Couck, Marijke; Gidron, Yori] Vrije Univ Brussel, Fac Med & Pharm, Brussels, Belgium.
   [Mravec, Boris] Comenius Univ, Fac Med, Inst Pathophysiol, Bratislava, Slovakia.
   [Mravec, Boris] Slovak Acad Sci, Inst Expt Endocrinol, Bratislava, Slovakia.
C3 Vrije Universiteit Brussel; Comenius University Bratislava; Slovak
   Academy of Sciences; Institute of Experimental Endocrinology, SAS
RP Gidron, Y (corresponding author), Vrije Univ Brussel, Fac Med & Pharm, Brussels, Belgium.
EM Yori.Gidron@vub.ac.be
OI Mravec, Boris/0000-0002-3177-6819
FU Reliable Cancer Therapies
FX This work was supported by Reliable Cancer Therapies (to Y.G.).
CR Aisen PS, 2002, LANCET NEUROL, V1, P279, DOI 10.1016/S1474-4422(02)00133-3
   [Anonymous], 2003, The world health report 2003: shaping the future
   Ärnlöv J, 2010, CIRCULATION, V121, P230, DOI 10.1161/CIRCULATIONAHA.109.887521
   Cherubini A, 2005, FREE RADICAL BIO MED, V39, P841, DOI 10.1016/j.freeradbiomed.2005.06.025
   Chiang JK, 2010, J PAIN SYMPTOM MANAG, V39, P673, DOI 10.1016/j.jpainsymman.2009.09.014
   Toledo MAD, 2010, CLIN AUTON RES, V20, P11, DOI 10.1007/s10286-009-0035-0
   Downing JEG, 2000, IMMUNOL TODAY, V21, P281, DOI 10.1016/S0167-5699(00)01635-2
   Dzau VJ, 2006, CIRCULATION, V114, P2850, DOI 10.1161/CIRCULATIONAHA.106.655688
   Ek M, 1998, J NEUROSCI, V18, P9471
   Entschladen F, 2004, LANCET ONCOL, V5, P254, DOI 10.1016/S1470-2045(04)01431-7
   Erin N, 2008, REGUL PEPTIDES, V151, P35, DOI 10.1016/j.regpep.2008.03.012
   Gidron Y, 2005, LANCET ONCOL, V6, P245, DOI 10.1016/S1470-2045(05)70096-6
   Goodarzi MT, 2010, J CLIN LAB ANAL, V24, P72, DOI 10.1002/jcla.20328
   He LY, 2010, NEUROL RES, V32, P530, DOI 10.1179/174313209X431110
   Janszky I, 2004, J INTERN MED, V256, P421, DOI 10.1111/j.1365-2796.2004.01403.x
   Johansen D, 2010, CANCER EPIDEM BIOMAR, V19, P2307, DOI 10.1158/1055-9965.EPI-10-0234
   Kawada T, 2006, AM J PHYSIOL-HEART C, V291, pH2187, DOI 10.1152/ajpheart.00175.2006
   Kraus T, 2007, J NEURAL TRANSM, V114, P1485, DOI 10.1007/s00702-007-0755-z
   Kruman I, 1997, J NEUROSCI, V17, P5089
   Kuo TBJ, 2005, J CARDIOVASC ELECTR, V16, P864, DOI 10.1111/j.1540-8167.2005.40656.x
   Kupper NHM, 2004, CIRCULATION, V110, P2792, DOI 10.1161/01.CIR.0000146334.96820.6E
   La Rovere MT, 1998, LANCET, V351, P478
   Lee ST, 2010, BRAIN RES, V1309, P164, DOI 10.1016/j.brainres.2009.10.076
   Licht CMM, 2010, J CLIN ENDOCR METAB, V95, P2458, DOI 10.1210/jc.2009-2801
   Loreti S, 2007, NEURON GLIA BIOL, V3, P269, DOI 10.1017/S1740925X08000045
   Mantovani A, 2008, NATURE, V454, P436, DOI 10.1038/nature07205
   Mathers CD, 2009, BRIT MED BULL, V92, P7, DOI 10.1093/bmb/ldp028
   Nagayoshi Y, 2005, AM J CARDIOL, V95, P514, DOI 10.1016/j.amjcard.2004.09.062
   Ottani A, 2009, J CEREBR BLOOD F MET, V29, P512, DOI 10.1038/jcbfm.2008.140
   Ozgocmen S, 2006, RHEUMATOL INT, V26, P585, DOI 10.1007/s00296-005-0078-z
   Remme WJ, 1998, EUR HEART J, V19, pF62
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Sajadieh A, 2006, J INTERN MED, V260, P377, DOI 10.1111/j.1365-2796.2006.01701.x
   Schlereth T, 2008, NEUROMOL MED, V10, P141, DOI 10.1007/s12017-007-8018-6
   Tal, 1999, Curr Rev Pain, V3, P440
   Tan G, 2009, PAIN MED, V10, P1237, DOI 10.1111/j.1526-4637.2009.00712.x
   Tarride Jean-Eric, 2009, Can J Cardiol, V25, pe195
   Tracey KJ, 2009, NAT REV IMMUNOL, V9, P418, DOI 10.1038/nri2566
   Tsutsumi T, 2008, CARDIOVASC RES, V77, P713, DOI 10.1093/cvr/cvm092
   Valko M, 2004, MOL CELL BIOCHEM, V266, P37, DOI 10.1023/B:MCBI.0000049134.69131.89
   Van Beek AHEA, 2011, BEHAV BRAIN RES, V221, P537, DOI 10.1016/j.bbr.2009.12.047
   Vlcek M, 2008, AUTON NEUROSCI-BASIC, V143, P53, DOI 10.1016/j.autneu.2008.08.001
   Voronov E, 2003, P NATL ACAD SCI USA, V100, P2645, DOI 10.1073/pnas.0437939100
   Westhuyzen J, 1997, ANN CLIN LAB SCI, V27, P1
   Zhao YJ, 2011, HEPATOLOGY, V53, P493, DOI 10.1002/hep.24079
NR 46
TC 66
Z9 71
U1 0
U2 28
PU PORTLAND PRESS LTD
PI LONDON
PA CHARLES DARWIN HOUSE, 12 ROGER STREET, LONDON WC1N 2JU, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD APR
PY 2012
VL 122
IS 7-8
BP 323
EP 328
DI 10.1042/CS20110299
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 926JQ
UT WOS:000302827700002
PM 22150254
DA 2025-06-11
ER

PT J
AU Eller, OC
   Morris, EM
   Thyfault, JP
   Christianson, JA
AF Eller, Olivia C.
   Morris, E. Matthew
   Thyfault, John P.
   Christianson, Julie A.
TI Early life stress reduces voluntary exercise and its prevention of
   diet-induced obesity and metabolic dysfunction in mice
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Metabolic syndrome; Obesity; Exercise; Early life stress; Diet;
   Inflammation
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; ADIPOSE-TISSUE;
   INSULIN-RESISTANCE; MATERNAL SEPARATION; BODY-WEIGHT; TREADMILL
   EXERCISE; MATHEMATICAL-MODEL; GLUCOSE-TOLERANCE; MAST-CELLS; FAT INTAKE
AB The development of obesity-related metabolic syndrome (MetS) involves a complex interaction of genetic and environmental factors. One environmental factor found to be significantly associated with MetS is early life stress (ELS). We have previously reported on our mouse model of ELS, induced by neonatal maternal separation (NMS), that displays altered regulation of the hypothalamic-pituitary-adrenal (HPA) axis and increased sensitivity in the urogenital organs, which was attenuated by voluntary wheel running. Here, we are using our NMS model to determine if ELS-induced changes in the HPA axis also influence weight gain and MetS. Naive (non-stressed) and NMS male mice were given free access to a running wheel and a low-fat control diet at 4-weeks of age. At 16-weeks of age, half of the mice were transitioned to a high fat/sucrose (HFS) diet to investigate if NMS influences the effectiveness of voluntary exercise to prevent diet-induced obesity and MetS. Overall, we observed a greater impact of voluntary exercise on prevention of HFS diet-induced outcomes in naive mice, compared to NMS mice. Although body weight and fat mass were still significantly higher, exercise attenuated fasting insulin levels and mRNA levels of inflammatory markers in epididymal adipose tissue in HFS diet-fed naive mice. Only moderate changes were observed in exercised NMS mice on a HFS diet, although this could partially be explained by reduced running distance within this group. Interestingly, sedentary NMS mice on a control diet displayed impaired glucose homeostasis and moderately increased pro-inflammatory mRNA levels in epididymal adipose, suggesting that early life stress alone impairs metabolic function and negatively impacts the therapeutic effect of voluntary exercise.
C1 [Eller, Olivia C.; Christianson, Julie A.] Univ Kansas, Sch Med, Dept Anat & Cell Biol, Med Ctr, Kansas City, KS 66160 USA.
   [Morris, E. Matthew; Thyfault, John P.] Univ Kansas, Sch Med, Dept Mol & Integrat Physiol, Med Ctr, Kansas City, KS 66160 USA.
C3 University of Kansas; University of Kansas Medical Center; University of
   Kansas; University of Kansas Medical Center
RP Christianson, JA (corresponding author), Univ Kansas, Dept Anat & Cell Biol, Med Ctr, 3901 Rainbow Blvd,MS 3038, Kansas City, KS 66160 USA.
EM jchristianson@kumc.edu
RI Eller-Smith, Olivia/IWE-4667-2023; Thyfault, John/JMB-3070-2023
OI Eller, Olivia/0000-0001-7694-855X; Thyfault, John/0000-0001-7920-7466
FU National Institutes of Health (NIH) [R01DK099611, R01DK103872,
   R01AR071263, K01DK112967, T32HD057850]; Idea Network of Biomedical
   Research Excellence (INBRE) Program [P20GM103418]; Kansas IDDRC
   [U54HD090216]; VA Merit Review [1I01BX002567]
FX This work was funded by the National Institutes of Health (NIH) grants
   R01DK099611 (JAC), R01DK103872 (JAC), R01AR071263 (JPT), K01DK112967
   (EMM), T32HD057850 (OCE), P20GM103418 (Idea Network of Biomedical
   Research Excellence (INBRE) Program), U54HD090216 (Kansas IDDRC), and VA
   Merit Review 1I01BX002567 (JPT).
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Ahima RS, 1998, J CLIN INVEST, V101, P1020, DOI 10.1172/JCI1176
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Altintas MM, 2011, J LIPID RES, V52, P480, DOI 10.1194/jlr.M011338
   Armitage JA, 2004, J PHYSIOL-LONDON, V561, P355, DOI 10.1113/jphysiol.2004.072009
   Booth FW, 2012, COMPR PHYSIOL, V2, P1143, DOI 10.1002/cphy.c110025
   BORKMAN M, 1991, J CLIN ENDOCR METAB, V72, P432, DOI 10.1210/jcem-72-2-432
   Bouret SG, 2006, CLIN GENET, V70, P295, DOI 10.1111/j.1399-0004.2006.00684.x
   Bray GA, 1998, AM J CLIN NUTR, V68, P1157, DOI 10.1093/ajcn/68.6.1157
   Brown William Virgil, 2004, Clin Cornerstone, V6 Suppl 3, pS30, DOI 10.1016/S1098-3597(04)80095-4
   Bryce CA, 2016, NEUROPSYCHOPHARMACOL, V41, P2147, DOI 10.1038/npp.2016.15
   Casteilla Louis, 2008, V456, P23, DOI 10.1007/978-1-59745-245-8_2
   CHROUSOS GP, 1992, JAMA-J AM MED ASSOC, V267, P1244, DOI 10.1001/jama.267.9.1244
   Danese A, 2014, MOL PSYCHIATR, V19, P544, DOI 10.1038/mp.2013.54
   Desbriere R, 2006, OBESITY, V14, P794, DOI 10.1038/oby.2006.92
   DiPietro L, 1999, INT J OBESITY, V23, P432, DOI 10.1038/sj.ijo.0800848
   Divoux A, 2012, J CLIN ENDOCR METAB, V97, pE1677, DOI 10.1210/jc.2012-1532
   Drake AJ, 2005, ENDOCRINOLOGY, V146, P913, DOI 10.1210/en.2004-1063
   Drewnowski A, 1997, NUTR REV, V55, P31, DOI 10.1111/j.1753-4887.1997.tb01593.x
   Fisher BE, 2013, NEUROREPORT, V24, P509, DOI 10.1097/WNR.0b013e328361dc13
   Friedman TC, 1996, ENDOCR J, V43, P645, DOI 10.1507/endocrj.43.645
   Fuentes IM, 2018, FRONT SYST NEUROSCI, V11, DOI 10.3389/fnsys.2017.00097
   Gollisch KSC, 2009, AM J PHYSIOL-ENDOC M, V297, pE495, DOI 10.1152/ajpendo.90424.2008
   Greenwood BN, 2011, BEHAV BRAIN RES, V217, P354, DOI 10.1016/j.bbr.2010.11.005
   Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
   Gurung P, 2019, AM J PHYSIOL-ENDOC M, V316, pE504, DOI 10.1152/ajpendo.00462.2018
   Hess PL, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.117.006103
   Holemans K, 2003, J PHYSIOL-LONDON, V547, P11, DOI 10.1113/jphysiol.2002.036582
   Hu FB, 1997, NEW ENGL J MED, V337, P1491, DOI 10.1056/NEJM199711203372102
   Jeanrenaud B, 2000, INT J OBESITY, V24, pS74, DOI 10.1038/sj.ijo.0801283
   Kaufman D, 2007, DIABETES, V56, P1382, DOI 10.2337/db06-1409
   Ke Z, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016643
   Kleinert M, 2018, NAT REV ENDOCRINOL, V14, P140, DOI 10.1038/nrendo.2017.161
   Leasure JL, 2008, NEUROSCIENCE, V156, P456, DOI 10.1016/j.neuroscience.2008.07.041
   Lesage J, 2004, J ENDOCRINOL, V181, P291, DOI 10.1677/joe.0.1810291
   LISSAU I, 1994, LANCET, V343, P324, DOI 10.1016/S0140-6736(94)91163-0
   Liu J, 2009, NAT MED, V15, P940, DOI 10.1038/nm.1994
   Lovallo WR, 2013, INT J PSYCHOPHYSIOL, V90, P8, DOI 10.1016/j.ijpsycho.2012.10.006
   Machado MV, 2017, EXP PHYSIOL, V102, P1716, DOI [10.1113/EP086416, 1]
   Maniam J, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00073
   Marrocco J, 2019, FRONT BEHAV NEUROSCI, V13, DOI 10.3389/fnbeh.2019.00157
   MCMURRY MP, 1991, NEW ENGL J MED, V325, P1704, DOI 10.1056/NEJM199112123252405
   Medzhitov R, 2008, NATURE, V454, P428, DOI 10.1038/nature07201
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   Morton NM, 2004, ENDOCRINOLOGY, V145, P2707, DOI 10.1210/en.2003-1674
   Murphy MO, 2018, INT J OBESITY, V42, P1354, DOI 10.1038/s41366-018-0035-z
   Nishikawa S, 2007, EXP ANIM TOKYO, V56, P263, DOI 10.1538/expanim.56.263
   Ostman C, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-017-0590-y
   Park YM, 2017, MED SCI SPORT EXER, V49, P254, DOI 10.1249/MSS.0000000000001101
   Pfaffl MW, 2001, NUCLEIC ACIDS RES, V29, DOI 10.1093/nar/29.9.e45
   Pierce AN, 2014, NEUROSCIENCE, V263, P216, DOI 10.1016/j.neuroscience.2014.01.022
   Pierce AN, 2018, NEUROUROL URODYNAM, V37, P1623, DOI 10.1002/nau.23530
   Pierce AN, 2016, BRAIN RES, V1639, P58, DOI 10.1016/j.brainres.2016.02.039
   Rask E, 2002, J CLIN ENDOCR METAB, V87, P3330, DOI 10.1210/jc.87.7.3330
   Rector RS, 2008, WORLD J GASTROENTERO, V14, P185, DOI 10.3748/wjg.14.185
   Remmers F, 2011, ENDOCR REV, V32, P272, DOI 10.1210/er.2009-0028
   Roberts CK, 2005, J APPL PHYSIOL, V98, P3, DOI 10.1152/japplphysiol.00852.2004
   Salzmann C, 2004, ENDOCRINOLOGY, V145, P1810, DOI 10.1210/en.2003-1514
   Scherer PE, 2016, DIABETES, V65, P1452, DOI 10.2337/db16-0339
   Schmidt MV, 2006, J NEUROENDOCRINOL, V18, P865, DOI 10.1111/j.1365-2826.2006.01482.x
   SISCOVICK DS, 1985, PUBLIC HEALTH REP, V100, P180
   SURWIT RS, 1995, METABOLISM, V44, P645, DOI 10.1016/0026-0495(95)90123-X
   Svensson M, 2016, NEUROBIOL STRESS, V5, P8, DOI 10.1016/j.ynstr.2016.09.002
   TAI MM, 1994, DIABETES CARE, V17, P152, DOI 10.2337/diacare.17.2.152
   Tarullo AR, 2006, HORM BEHAV, V50, P632, DOI 10.1016/j.yhbeh.2006.06.010
   Thyfault JP, 2011, CURR OPIN CLIN NUTR, V14, P374, DOI 10.1097/MCO.0b013e3283468e69
   Tomlinson JW, 2004, ENDOCR REV, V25, P831, DOI 10.1210/er.2003-0031
   Torjesen PA, 1997, DIABETES CARE, V20, P26, DOI 10.2337/diacare.20.1.26
   Touati S, 2011, MED SCI SPORT EXER, V43, P398, DOI 10.1249/MSS.0b013e3181eeb12d
   Uysal KT, 1997, NATURE, V389, P610, DOI 10.1038/39335
   Van Craenenbroeck K, 2005, MOL CELL ENDOCRINOL, V245, P10, DOI 10.1016/j.mce.2005.10.007
   Vanltallie TB, 2002, METABOLISM, V51, P40, DOI 10.1053/meta.2002.33191
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Williamson DF, 2002, INT J OBESITY, V26, P1075, DOI 10.1038/sj.ijo.0802038
   Winzell MS, 2004, DIABETES, V53, pS215, DOI 10.2337/diabetes.53.suppl_3.S215
   Wise RA, 2002, NEURON, V36, P229, DOI 10.1016/S0896-6273(02)00965-0
   Xu XH, 2011, AM J PHYSIOL-REG I, V300, pR1115, DOI 10.1152/ajpregu.00806.2010
   Yajnik CS, 2004, J NUTR, V134, P205, DOI 10.1093/jn/134.1.205
   Yam KY, 2017, PSYCHONEUROENDOCRINO, V77, P186, DOI 10.1016/j.psyneuen.2016.12.012
NR 80
TC 18
Z9 18
U1 0
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD SEP 1
PY 2020
VL 223
AR 113000
DI 10.1016/j.physbeh.2020.113000
PG 10
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA MN0ZU
UT WOS:000550576800040
PM 32512033
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Thörn, K
   Hovsepyan, M
   Bergsten, P
AF Thorn, Kristofer
   Hovsepyan, Meri
   Bergsten, Peter
TI Reduced levels of SCD1 accentuate palmitate-induced stress in
   insulin-producing β-cells
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
ID STEAROYL-COA DESATURASE-1; ENDOPLASMIC-RETICULUM STRESS; COENZYME-A
   DESATURASE; FATTY-ACID OXIDATION; PROTECTS MICE; EXPRESSION; MUSCLE;
   SENSITIVITY; INHIBITORS; APOPTOSIS
AB Background: Stearoyl-CoA desaturase 1 (SCD1) is an ER resident enzyme introducing a double-bond in saturated fatty acids. Global knockout of SCD1 in mouse increases fatty acid oxidation and insulin sensitivity which makes the animal resistant to diet-induced obesity. Inhibition of SCD1 has therefore been proposed as a potential therapy of the metabolic syndrome. Much of the work has focused on insulin target tissue and very little is known about how reduced levels of SCD1 would affect the insulin-producing beta-cell, however. The aim of the present study was therefore to investigate how reduced levels of SCD1 affect the beta-cell.
   Results: Insulin-secreting MIN6 cells with reduced levels of SCD1 were established by siRNA mediated knockdown. When fatty acid oxidation was measured, no difference between cells with reduced levels of SCD1 and mock-transfected cells were found. Also, reducing levels of SCD1 did not affect insulin secretion in response to glucose. To investigate how SCD1 knockdown affected cellular mechanisms, differentially regulated proteins were identified by a proteomic approach. Cells with reduced levels of SCD1 had higher levels of ER chaperones and components of the proteasome. The higher amounts did not protect the beta-cell from palmitate-induced ER stress and apoptosis. Instead, rise in levels of p-eIF2 alpha and CHOP after palmitate exposure was 2-fold higher in cells with reduced levels of SCD1 compared to mock-transfected cells. Accordingly, apoptosis rose to higher levels after exposure to palmitate in cells with reduced levels of SCD1 compared to mock-transfected cells.
   Conclusions: In conclusion, reduced levels of SCD1 augment palmitate-induced ER stress and apoptosis in the beta-cell, which is an important caveat when considering targeting this enzyme as a treatment of the metabolic syndrome.
C1 [Thorn, Kristofer; Hovsepyan, Meri; Bergsten, Peter] Uppsala Univ, Dept Med Cell Biol, S-75123 Uppsala, Sweden.
   [Hovsepyan, Meri] Armenian Natl Acad Sci, Inst Mol Biol, Yerevan 0014, Armenia.
C3 Uppsala University; National Academy of Sciences of Armenia; Institute
   of Molecular Biology - NAS RA
RP Thörn, K (corresponding author), Uppsala Univ, Dept Med Cell Biol, BMC Box 571, S-75123 Uppsala, Sweden.
EM kristofer.thorn@mcb.uu.se
FU Swedish Medical Research Council [72X-14019]; European Foundation for
   the Study of Diabetes; Swedish Diabetes Association; Swedish Medical
   Association; Family Ernfors Fund
FX This work was supported by grants from the Swedish Medical Research
   Council (72X-14019), the European Foundation for the Study of Diabetes,
   the Swedish Diabetes Association, the Swedish Medical Association and
   Family Ernfors Fund.
CR Ariyama H, 2010, J BIOL CHEM, V285, P22027, DOI 10.1074/jbc.M110.126870
   Attie AD, 2002, J LIPID RES, V43, P1899, DOI 10.1194/jlr.M200189-JLR200
   BERGSTEN P, 1993, BIOCHEM BIOPH RES CO, V192, P1182, DOI 10.1006/bbrc.1993.1541
   Borge PD, 2002, DIABETES, V51, pS427, DOI 10.2337/diabetes.51.2007.S427
   Brown JM, 2010, CURR OPIN LIPIDOL, V21, P192, DOI 10.1097/MOL.0b013e32833854ac
   Busch AK, 2005, DIABETES, V54, P2917, DOI 10.2337/diabetes.54.10.2917
   Diakogiannaki E, 2008, BIOCHEM SOC T, V36, P959, DOI 10.1042/BST0360959
   Dobrzyn P, 2004, P NATL ACAD SCI USA, V101, P6409, DOI 10.1073/pnas.0401627101
   Dobrzyn P, 2008, AM J PHYSIOL-ENDOC M, V294, pE357, DOI 10.1152/ajpendo.00471.2007
   Eizirik DL, 2008, ENDOCR REV, V29, P42, DOI 10.1210/er.2007-0015
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   Herbert TP, 2007, BIOCHEM SOC T, V35, P1205, DOI 10.1042/BST0351205
   HOVSEPYAN M, 2010, J PROTEOMICS
   Hulver MW, 2005, CELL METAB, V2, P251, DOI 10.1016/j.cmet.2005.09.002
   Issandou M, 2009, EUR J PHARMACOL, V618, P28, DOI 10.1016/j.ejphar.2009.07.004
   Jiang GQ, 2005, J CLIN INVEST, V115, P1030, DOI 10.1172/JCI200523962
   Karaskov E, 2006, ENDOCRINOLOGY, V147, P3398, DOI 10.1210/en.2005-1494
   Li CS, 2009, BIOORG MED CHEM LETT, V19, P5214, DOI 10.1016/j.bmcl.2009.07.015
   Liu G, 2009, EXPERT OPIN THER PAT, V19, P1169, DOI 10.1517/13543770903061311
   Liu XQ, 2010, ARTERIOSCL THROM VAS, V30, P31, DOI 10.1161/ATVBAHA.109.195636
   Miyazaki M, 2006, J LIPID RES, V47, P700, DOI 10.1194/jlr.C500025-JLR200
   Miyazaki M, 2003, PROSTAG LEUKOTR ESS, V68, P113, DOI 10.1016/S0952-3278(02)00261-2
   Ntambi JM, 2002, P NATL ACAD SCI USA, V99, P11482, DOI 10.1073/pnas.132384699
   Peter A, 2009, DIABETES, V58, P1757, DOI 10.2337/db09-0188
   Rahman SM, 2003, P NATL ACAD SCI USA, V100, P11110, DOI 10.1073/pnas.1934571100
   Rockett BD, 2010, J LIPID RES, V51, P1284, DOI 10.1194/jlr.M000851
   Sampath H, 2007, J BIOL CHEM, V282, P2483, DOI 10.1074/jbc.M610158200
   Sampath H, 2009, J BIOL CHEM, V284, P19961, DOI 10.1074/jbc.M109.014225
   Song BB, 2008, J CLIN INVEST, V118, P3378, DOI 10.1172/JCI34587
   Wang J, 2005, BIOCHEM BIOPH RES CO, V332, P735, DOI 10.1016/j.bbrc.2005.05.013
   Wei Y, 2007, MOL CELL BIOCHEM, V303, P105, DOI 10.1007/s11010-007-9461-2
   Zhang L, 1999, BIOCHEM J, V340, P255, DOI 10.1042/0264-6021:3400255
NR 32
TC 35
Z9 39
U1 0
U2 11
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD SEP 29
PY 2010
VL 9
AR 108
DI 10.1186/1476-511X-9-108
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 667EC
UT WOS:000283174500001
PM 20920255
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Slyepchenko, A
   Maes, M
   Jacka, FN
   Köhler, CA
   Barichello, T
   McIntyre, RS
   Berk, M
   Grande, I
   Foster, JA
   Vieta, E
   Carvalho, AF
AF Slyepchenko, Anastasiya
   Maes, Michael
   Jacka, Felice N.
   Koehler, Cristiano A.
   Barichello, Tatiana
   McIntyre, Roger S.
   Berk, Michael
   Grande, Iria
   Foster, Jane A.
   Vieta, Eduard
   Carvalho, Andre F.
TI Gut Microbiota, Bacterial Translocation, and Interactions with Diet:
   Pathophysiological Links between Major Depressive Disorder and Non
   Communicable Medical Comorbidities
SO PSYCHOTHERAPY AND PSYCHOSOMATICS
LA English
DT Article
DE Mood disorders; Obesity; Depression; Diabetes; Microbiota; Chronic
   fatigue syndrome; Inflammation; Psychiatry; Irritable bowel syndrome;
   Oxidative stress
ID IRRITABLE-BOWEL-SYNDROME; CHRONIC-FATIGUE-SYNDROME; GRAM-NEGATIVE
   ENTEROBACTERIA; MESENTERIC LYMPH-NODES; C-REACTIVE PROTEIN; NITROSATIVE
   STRESS; OXIDATIVE STRESS; ADIPOSE-TISSUE; IMMUNE-SYSTEM; METABOLIC
   SYNDROME
AB Background: Persistent low-grade immune-inflammatory processes, oxidative and nitrosative stress (O&NS), and hypothalamic-pituitary-adrenal axis activation are integral to the pathophysiology of major depressive disorder (MDD). The microbiome, intestinal compositional changes, and resultant bacterial translocation add a new element to the bidirectional interactions of the gut -brain axis; new evidence implicates these pathways in the patho-aetiology of MDD. In addition, abnormalities in the gut-brain axis are associated with several chronic non-communicable disorders, which frequently co-occur in individuals with MDD, including but not limited to irritable bowel syndrome (IBS), chronic fatigue syndrome (CFS), obesity, and type 2 diabetes mellitus (T2DM). Methods: We searched the PubMed/MEDLINE database up until May 1, 2016 for studies which investigated intestinal dysbiosis and bacterial translocation (the 'leaky gut') in the pathophysiology of MDD and co-occurring somatic comorbidities with an emphasis on IBS, CFS, obesity, and T2DM. Results: The composition of the gut microbiota is influenced by several genetic and environmental factors (e.g. diet). Several lines of evidence indicate that gut-microbiotadiet interactions play a significant pathophysiological role in MDD and related medical comorbidities. Gut dysbiosis and the leaky gut may influence several pathways implicated in the biology of MDD, including but not limited to immune activation, O&NS, and neuroplasticity cascades. However, methodological inconsistencies and limitations limit comparisons across studies. Conclusions: Intestinal dysbiosis and the leaky gut may constitute a key pathophysiological link between MDD and its medical comorbidities. This emerging literature opens relevant preventative and therapeutic perspectives. (C) 2016 S. Karger AG, Basel
C1 [Slyepchenko, Anastasiya] McMaster Univ, McMaster Integrat Neurosci Discovery & Study MiND, Hamilton, ON, Canada.
   [Maes, Michael; Jacka, Felice N.; Berk, Michael] Deakin Univ, Sch Med & Barwon Hlth, IMPACT Strateg Res Ctr, Geelong, Vic, Australia.
   [Maes, Michael] Chulalongkorn Univ, Dept Psychiat, Fac Med, Bangkok, Thailand.
   [Maes, Michael] Univ Estadual Londrina, Dept Psychiat, Fac Med, Londrina, Brazil.
   [Maes, Michael] Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria.
   [Maes, Michael] Revitalis, Waalre, Netherlands.
   [Jacka, Felice N.] Univ Melbourne, Dept Psychiat, Parkville, Vic, Australia.
   [Jacka, Felice N.] Murdoch Childrens Res Inst, Ctr Adolescent Hlth, Melbourne, Vic, Australia.
   [Jacka, Felice N.] Black Dog Inst, Sydney, NSW, Australia.
   [Koehler, Cristiano A.; Carvalho, Andre F.] Univ Fed Ceara, Dept Clin Med, Fortaleza, Ceara, Brazil.
   [Koehler, Cristiano A.] Univ Fed Ceara, Translat Psychiat Res Grp, Fac Med, Fortaleza, Ceara, Brazil.
   [Barichello, Tatiana] Univ Texas Hlth Sci Ctr Houston UTHlth, McGovern Med Sch, Dept Psychiat & Behav Sci, Translat Psychiat Program, Houston, TX USA.
   [McIntyre, Roger S.] Univ Toronto, Univ Hlth Network, Dept Psychiat, Mood Disorder Psychopharmacol Unit, Toronto, ON, Canada.
   [Berk, Michael] Univ Melbourne, Orygen, Natl Ctr Excellence Youth Mental Hlth, Dept Psychiat, Parkville, Vic, Australia.
   [Berk, Michael] Univ Melbourne, Ctr Youth Mental Hlth, Dept Psychiat, Parkville, Vic, Australia.
   [Berk, Michael] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia.
   [Grande, Iria; Vieta, Eduard] Univ Barcelona, CIBERSAM, IDIBAPS, Bipolar Disorder Unit,Inst Neurosci,Hosp Clin, Barcelona, Spain.
   [Foster, Jane A.] McMaster Univ, Brain Body Inst, St Josephs Healthcare, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada.
C3 McMaster University; Deakin University; Chulalongkorn University;
   Universidade Estadual de Londrina; Medical University Plovdiv;
   University of Melbourne; Murdoch Children's Research Institute; Black
   Dog Institute; Universidade Federal do Ceara; Universidade Federal do
   Ceara; University of Texas System; University of Texas Health Science
   Center Houston; Baylor College of Medicine; Baylor College Medical
   Hospital; University of Toronto; University Health Network Toronto;
   Orygen, The National Centre of Excellence in Youth Mental Health;
   University of Melbourne; University of Melbourne; Orygen, The National
   Centre of Excellence in Youth Mental Health; Florey Institute of
   Neuroscience & Mental Health; University of Melbourne; University of
   Barcelona; Hospital Clinic de Barcelona; IDIBAPS; CIBER - Centro de
   Investigacion Biomedica en Red; CIBERSAM; McMaster University
RP Carvalho, AF (corresponding author), Univ Fed Ceara, Dept Clin Med, Fac Med, Rua Prof Costa Mendes 1608,4 Andar, BR-60430040 Fortaleza, CE, Brazil.
EM andrefc7@terra.com.br
RI McIntyre, Roger/AAU-1000-2020; Grande, Iria/AAF-9342-2021; Foster,
   Jane/AAW-7163-2021; Slyepchenko, Anastasiya/AAK-6000-2021; Jacka,
   Felice/ABE-6322-2020; Barichello, Tatiana/E-2725-2013; Berk,
   Michael/AGH-9427-2022; Carvalho, Andre/AEZ-4001-2022; Vieta,
   Eduard/Y-2919-2019; Maes, Michael/B-8546-2011; Berk,
   Michael/M-7891-2013; Vieta, Eduard/I-6330-2013
OI Berk, Michael/0000-0002-5554-6946; Maes, Michael/0000-0002-2012-871X;
   Vieta, Eduard/0000-0002-0548-0053; Foster, Jane/0000-0002-8579-4705;
   Barichello, Tatiana/0000-0001-7776-8454; Slyepchenko,
   Anastasiya/0000-0003-0179-2129
FU CAPES (Brazil); National Health and Medical Research Council (NHMRC)
   Senior Principal Research Fellowship [1059660]; Juan Rodes research
   contract at the Instituto de Salud Carlos III, Spanish Ministry of
   Economy and Competiveness, Barcelona (Spain) [JR15/00012]; Instituto de
   Salud Carlos III; Spanish Ministry of Economy and Competiveness;
   CIBERSAM [PI12/00912]; Grups Consolidats de Recerca [SGR 398]; Seventh
   European Framework Programme (ENBREC); Stanley Medical Research
   Institute; CNPq (Brazil)
FX C.A.K. is supported by a postdoctoral research fellowship from CAPES
   (Brazil). M.B. is supported by a National Health and Medical Research
   Council (NHMRC) Senior Principal Research Fellowship (1059660). I.G. has
   received a Juan Rodes research contract (JR15/00012) at the Instituto de
   Salud Carlos III, Spanish Ministry of Economy and Competiveness,
   Barcelona (Spain). E.V. thanks the Instituto de Salud Carlos III,
   Spanish Ministry of Economy and Competiveness, CIBERSAM (PI12/00912),
   the Grups Consolidats de Recerca 2014 (SGR 398), the Seventh European
   Framework Programme (ENBREC), and the Stanley Medical Research Institute
   for their support. A.F.C. is supported by a research fellowship award
   from CNPq (Brazil).
CR Ali S, 2006, DIABETIC MED, V23, P1165, DOI 10.1111/j.1464-5491.2006.01943.x
   An S, 2016, NEUROGASTROENT MOTIL, V28, P1083, DOI 10.1111/nmo.12811
   Bansal AS, 2012, BRAIN BEHAV IMMUN, V26, P24, DOI 10.1016/j.bbi.2011.06.016
   Baranyi A, 2013, PSYCHOTHER PSYCHOSOM, V82, P332, DOI 10.1159/000348587
   Benros ME, 2013, JAMA PSYCHIAT, V70, P812, DOI 10.1001/jamapsychiatry.2013.1111
   Benton D, 2007, EUR J CLIN NUTR, V61, P355, DOI 10.1038/sj.ejcn.1602546
   BERG RD, 1979, INFECT IMMUN, V23, P403, DOI 10.1128/IAI.23.2.403-411.1979
   Berk M, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-74
   Biasucci G, 2010, EARLY HUM DEV, V86, pS13, DOI 10.1016/j.earlhumdev.2010.01.004
   Boren J, 2003, J BIOL CHEM, V278, P28395, DOI 10.1074/jbc.M302932200
   Brandt LJ, 2002, AM J GASTROENTEROL, V97, pS7
   Braniste V, 2014, SCI TRANSL MED, V6, DOI 10.1126/scitranslmed.3009759
   Brunoni AR, 2008, INT J NEUROPSYCHOPH, V11, P1169, DOI 10.1017/S1461145708009309
   Cani PD, 2009, GUT, V58, P1091, DOI 10.1136/gut.2008.165886
   Chadwick VS, 2002, GASTROENTEROLOGY, V122, P1778, DOI 10.1053/gast.2002.33579
   Chan ED, 2001, AM J PHYSIOL-CELL PH, V280, pC441, DOI 10.1152/ajpcell.2001.280.3.C441
   Check J, 2010, MOL IMMUNOL, V47, P756, DOI 10.1016/j.molimm.2009.10.012
   Chen R, 2008, J INT MED RES, V36, P867, DOI 10.1177/147323000803600501
   Choi J, 2013, OBES REV, V14, P232, DOI 10.1111/obr.12003
   Clark Jeanne M, 2002, Curr Diab Rep, V2, P210, DOI 10.1007/s11892-002-0085-3
   Clavel T, 2010, INT J SYST EVOL MICR, V60, P1527, DOI 10.1099/ijs.0.015016-0
   Collins SM, 2009, DIGEST LIVER DIS, V41, P850, DOI 10.1016/j.dld.2009.07.023
   Creely SJ, 2007, AM J PHYSIOL-ENDOC M, V292, pE740, DOI 10.1152/ajpendo.00302.2006
   Cryan JF, 2012, NAT REV NEUROSCI, V13, P701, DOI 10.1038/nrn3346
   Dash S, 2015, CURR OPIN PSYCHIATR, V28, P1, DOI 10.1097/YCO.0000000000000117
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   Debnath M, 2016, OBES RES CLIN PRACT, V10, P103, DOI 10.1016/j.orcp.2015.10.012
   Dhiman RK, 2013, METAB BRAIN DIS, V28, P321, DOI 10.1007/s11011-013-9388-0
   Didari T, 2015, WORLD J GASTROENTERO, V21, P3072, DOI 10.3748/wjg.v21.i10.3072
   Diehl GE, 2013, NATURE, V494, P116, DOI 10.1038/nature11809
   Dinan TG, 2006, GASTROENTEROLOGY, V130, P304, DOI 10.1053/j.gastro.2005.11.033
   Dipnall JF, 2015, J AFFECT DISORDERS, V174, P215, DOI 10.1016/j.jad.2014.11.030
   Dirmaier J, 2010, PSYCHOTHER PSYCHOSOM, V79, P172, DOI 10.1159/000296135
   Distrutti E, 2016, WORLD J GASTROENTERO, V22, P2219, DOI 10.3748/wjg.v22.i7.2219
   Dlugosz A, 2015, NEUROGASTROENT MOTIL, V27, P1747, DOI 10.1111/nmo.12670
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Drossman DA, 2002, GASTROENTEROLOGY, V123, P2108, DOI 10.1053/gast.2002.37095
   Drossman DA, 2000, AM J GASTROENTEROL, V95, P974
   Duck LW, 2007, INFLAMM BOWEL DIS, V13, P1191, DOI 10.1002/ibd.20237
   Duncan SH, 2002, INT J SYST EVOL MICR, V52, P2141, DOI [10.1099/ijs.0.02241-0, 10.1099/00207713-52-6-2141]
   Dvorak K, 2007, GUT, V56, P763, DOI 10.1136/gut.2006.103697
   Elinav E, 2011, CELL, V145, P745, DOI 10.1016/j.cell.2011.04.022
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Fava GA, 2014, PSYCHOTHER PSYCHOSOM, V83, P136, DOI 10.1159/000360348
   Fleissner CK, 2010, BRIT J NUTR, V104, P919, DOI 10.1017/S0007114510001303
   Fletcher MA, 2009, J TRANSL MED, V7, DOI 10.1186/1479-5876-7-96
   Fond G, 2015, PATHOL BIOL, V63, P35, DOI 10.1016/j.patbio.2014.10.003
   Foster JA, 2013, TRENDS NEUROSCI, V36, P305, DOI 10.1016/j.tins.2013.01.005
   Frémont M, 2013, ANAEROBE, V22, P50, DOI 10.1016/j.anaerobe.2013.06.002
   Gaab J, 2005, PSYCHONEUROENDOCRINO, V30, P188, DOI 10.1016/j.psyneuen.2004.06.008
   Gawryluk JW, 2011, INT J NEUROPSYCHOPH, V14, P123, DOI 10.1017/S1461145710000805
   Gecse K, 2012, DIGESTION, V85, P40, DOI 10.1159/000333083
   Gerard Philippe, 2013, Pathogens, V3, P14, DOI 10.3390/pathogens3010014
   Ghanizadeh A, 2013, MED GAS RES, V3, DOI 10.1186/2045-9912-3-11
   Gnauck A, 2015, INT REV IMMUNOL, P1
   Grant RW, 2015, OBESITY, V23, P512, DOI 10.1002/oby.21003
   Griffith James P, 2008, Prim Care Companion J Clin Psychiatry, V10, P120
   Grigoleit JS, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0028330
   Hall DM, 2001, AM J PHYSIOL-HEART C, V280, pH509, DOI 10.1152/ajpheart.2001.280.2.H509
   Haro C, 2015, J CLIN ENDOCR METAB, V101, P233
   Harte AL, 2012, DIABETES CARE, V35, P375, DOI 10.2337/dc11-1593
   Herder C, 2005, GESUNDHEITSWESEN, V67, pS115, DOI 10.1055/s-2005-858252
   Hersoug LG, 2016, OBES REV, V17, P297, DOI 10.1111/obr.12370
   Hildebrandt MA, 2009, GASTROENTEROLOGY, V137, P1716, DOI 10.1053/j.gastro.2009.08.042
   Hiles SA, 2016, DEPRESS ANXIETY, V33, P754, DOI 10.1002/da.22512
   Hill C, 2014, NAT REV GASTRO HEPAT, V11, P506, DOI 10.1038/nrgastro.2014.66
   Huang XL, 2016, EUR J INTERN MED, V27, P37, DOI 10.1016/j.ejim.2015.11.016
   Iovine NM, 2008, INFECT IMMUN, V76, P986, DOI 10.1128/IAI.01063-07
   Iseme RA, 2014, NEUROSCI BIOBEHAV R, V40, P62, DOI 10.1016/j.neubiorev.2014.01.008
   Jacka FN, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/1471-244X-14-132
   Jacka FN, 2012, PSYCHOTHER PSYCHOSOM, V81, P196, DOI 10.1159/000334910
   Jakobsson HE, 2014, GUT, V63, P559, DOI 10.1136/gutjnl-2012-303249
   Janssens KAM, 2015, PSYCHOSOM MED, V77, P449, DOI 10.1097/PSY.0000000000000161
   Jiang HY, 2015, BRAIN BEHAV IMMUN, V48, P186, DOI 10.1016/j.bbi.2015.03.016
   Johnston BC, 2014, JAMA-J AM MED ASSOC, V312, P923, DOI 10.1001/jama.2014.10397
   Jones A, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039143
   Karlsson CLJ, 2012, OBESITY, V20, P2257, DOI 10.1038/oby.2012.110
   Karlsson FH, 2013, NATURE, V498, P99, DOI 10.1038/nature12198
   Kashtanova DA, 2016, NUTRITION, V32, P620, DOI 10.1016/j.nut.2015.12.037
   Kassinen A, 2007, GASTROENTEROLOGY, V133, P24, DOI 10.1053/j.gastro.2007.04.005
   Kiecolt-Glaser JK, 2015, AM J PSYCHIAT, V172, P1075, DOI 10.1176/appi.ajp.2015.15020152
   Kimura I, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms2852
   Kobyliak N, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0067-0
   Kohlgruber A, 2015, CURR DIABETES REP, V15, DOI 10.1007/s11892-015-0670-x
   Lai JS, 2014, AM J CLIN NUTR, V99, P181, DOI 10.3945/ajcn.113.069880
   Lakhan SE, 2010, NUTR METAB, V7, DOI 10.1186/1743-7075-7-79
   LANE TJ, 1991, AM J MED, V91, P335, DOI 10.1016/0002-9343(91)90150-V
   Lasserre AM, 2014, JAMA PSYCHIAT, V71, P880, DOI 10.1001/jamapsychiatry.2014.411
   Lee CC, 2009, DIABETOLOGIA, V52, P1040, DOI 10.1007/s00125-009-1338-3
   Leonard B, 2012, NEUROSCI BIOBEHAV R, V36, P764, DOI 10.1016/j.neubiorev.2011.12.005
   LEWIS CE, 1990, IMMUNOLOGY, V69, P402
   Lewis K, 2010, INFLAMM BOWEL DIS, V16, P1138, DOI 10.1002/ibd.21177
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Li B, 2015, MOL NEUROBIOL
   Liebregts T, 2007, GASTROENTEROLOGY, V132, P913, DOI 10.1053/j.gastro.2007.01.046
   Lin HP, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0035240, 10.1371/journal.pone.0031286]
   Lin WN, 2011, BRIT J PHARMACOL, V163, P1691, DOI 10.1111/j.1476-5381.2011.01312.x
   Liu CS, 2014, CNS NEUROL DISORD-DR, V13, P1693
   Liu Y, 2012, J AFFECT DISORDERS, V139, P230, DOI 10.1016/j.jad.2011.08.003
   Logan AC, 2003, MED HYPOTHESES, V60, P915, DOI 10.1016/S0306-9877(03)00096-3
   Lorenzi M, 2015, VALUE HEALTH, V18, pA598, DOI 10.1016/j.jval.2015.09.2049
   Lorusso L, 2009, AUTOIMMUN REV, V8, P287, DOI 10.1016/j.autrev.2008.08.003
   Lotrich FE, 2015, BRAIN RES, V1617, P113, DOI 10.1016/j.brainres.2014.06.032
   Lucas K, 2013, MOL NEUROBIOL, V48, P190, DOI 10.1007/s12035-013-8425-7
   Macfarlane GT., 1997, GASTROINTESTINAL MIC, P269, DOI DOI 10.1007/978-1-4615-4111-0_9
   Maes M, 2013, ACTA PSYCHIAT SCAND, V127, P344, DOI 10.1111/j.1600-0447.2012.01908.x
   Maes M, 2008, NEUROENDOCRINOL LETT, V29, P287
   Maes M, 2008, NEUROENDOCRINOL LETT, V29, P117
   Maes M, 2007, NEUROENDOCRINOL LETT, V28, P861
   Maes M, 2007, NEUROENDOCRINOL LETT, V28, P463
   Maes M, 2007, J AFFECT DISORDERS, V99, P237, DOI 10.1016/j.jad.2006.08.021
   Maes M, 2006, NEUROENDOCRINOL LETT, V27, P615
   Maes M, 2013, J AFFECT DISORDERS, V150, P223, DOI 10.1016/j.jad.2013.03.029
   Maes M, 2012, J AFFECT DISORDERS, V141, P55, DOI 10.1016/j.jad.2012.02.023
   Maes M, 2012, PSYCHOTHER PSYCHOSOM, V81, P286, DOI 10.1159/000336803
   Maes M, 2012, J AFFECT DISORDERS, V136, P909, DOI 10.1016/j.jad.2011.09.010
   Maes M, 2009, NEUROENDOCRINOL LETT, V30, P715
   Mahajan S, 2014, PSYCHOTHER PSYCHOSOM, V83, P308, DOI 10.1159/000358527
   McIntyre RS, 2013, BEHAV BRAIN RES, V237, P164, DOI 10.1016/j.bbr.2012.09.021
   Mehlhase J, 2000, IUBMB LIFE, V50, P331, DOI 10.1080/15216540051081137
   Moayyedi P, 2015, CLIN TRANSL GASTROEN, V6, DOI 10.1038/ctg.2015.21
   Monk JM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0049739
   Moreno-Indias I, 2016, FOOD FUNCT, V7, P1775, DOI [10.1039/C5FO00886G, 10.1039/c5fo00886g]
   Morris G, 2015, BMC MED, V13, DOI 10.1186/s12916-015-0310-y
   Morris G, 2014, CURR NEUROPHARMACOL, V12, P168, DOI 10.2174/1570159X11666131120224653
   Morris G, 2014, MOL NEUROBIOL, V49, P741, DOI 10.1007/s12035-013-8553-0
   Moylan S, 2013, MOL PSYCHIATR, V18, P595, DOI 10.1038/mp.2012.33
   Moylan S, 2015, LANCET PSYCHIAT, V2, P1044, DOI 10.1016/S2215-0366(15)00475-7
   Moylan S, 2014, NEUROSCI BIOBEHAV R, V45, P46, DOI 10.1016/j.neubiorev.2014.05.007
   Mujica-Parodi LR, 2009, INT J OBESITY, V33, P157, DOI 10.1038/ijo.2008.218
   Murphy EA, 2015, CURR OPIN CLIN NUTR, V18, P515, DOI 10.1097/MCO.0000000000000209
   Myhill S, 2009, INT J CLIN EXP MED, V2, P1
   Nakao M, 1998, PSYCHOTHER PSYCHOSOM, V67, P43, DOI 10.1159/000012258
   Naseribafrouei A, 2014, NEUROGASTROENT MOTIL, V26, P1155, DOI 10.1111/nmo.12378
   Nemeroff CB, 2005, J CLIN PSYCHIAT, V66, P5
   Nishikawa T, 2000, NATURE, V404, P787, DOI 10.1038/35008121
   O'Keefe SJD, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms7342
   O'Mahony C, 2008, PLOS PATHOG, V4, DOI 10.1371/journal.ppat.1000112
   O'Mahony L, 2005, GASTROENTEROLOGY, V128, P541, DOI 10.1053/j.gastro.2004.11.050
   O'Neil A, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-114
   Ogawa H, 2003, BIOCHEM BIOPH RES CO, V309, P512, DOI 10.1016/j.bbrc.2003.08.026
   Ogbonnaya ES, 2015, BIOL PSYCHIAT, V78, pE7, DOI 10.1016/j.biopsych.2014.12.023
   Öhman L, 2009, NEUROGASTROENT MOTIL, V21, DOI 10.1111/j.1365-2982.2009.01272.x
   Öhman L, 2009, AM J GASTROENTEROL, V104, P1205, DOI 10.1038/ajg.2009.116
   Opie RS, 2015, PUBLIC HEALTH NUTR, V18, P2074, DOI 10.1017/S1368980014002614
   Opie RS, 2015, NUTR NEUROSCI
   PAI K, 1991, Indian Journal of Experimental Biology, V29, P910
   Palmer C, 2007, PLOS BIOL, V5, P1556, DOI 10.1371/journal.pbio.0050177
   Palsson AS, 2005, GASTROENTEROL CLIN N, V34, P281, DOI 10.1016/j.gtc.2005.02.004
   Pariante Carmine M, 2006, J Psychopharmacol, V20, P79, DOI 10.1177/1359786806066063
   Pasco JA, 2015, PSYCHOTHER PSYCHOSOM, V84, P384, DOI 10.1159/000381831
   Patterson E, 2016, POSTGRAD MED J, V92, P286, DOI 10.1136/postgradmedj-2015-133285
   Peng LY, 2009, J NUTR, V139, P1619, DOI 10.3945/jn.109.104638
   Peng TQ, 2004, FASEB J, V18, P293, DOI 10.1096/fj.04-2289fje
   Phillips JGP, 1910, J MENT SCI, V56, P422, DOI 10.1192/bjp.56.234.422
   Pickup JC, 1997, DIABETOLOGIA, V40, P1286, DOI 10.1007/s001250050822
   Pineiro M, 2008, J CLIN GASTROENTEROL, V42, pS156, DOI 10.1097/MCG.0b013e31817f184e
   Prakash S, 2011, BIOL-TARGETS THER, V5, P71, DOI 10.2147/BTT.S19099
   Qin JJ, 2010, NATURE, V464, P59, DOI 10.1038/nature08821
   Quigley EMM, 2003, SCAND J GASTROENTERO, V38, P1, DOI 10.1080/00855910310001403
   Rajilic-Stojanovic M, 2011, GASTROENTEROLOGY, V141, P1792, DOI 10.1053/j.gastro.2011.07.043
   Rakoff-Nahoum S, 2004, CELL, V118, P229, DOI 10.1016/j.cell.2004.07.002
   Rao AV, 2009, GUT PATHOG, V1, DOI 10.1186/1757-4749-1-6
   REUS VI, 1982, NEW ENGL J MED, V306, P238
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Ridlon JM, 2006, J LIPID RES, V47, P241, DOI 10.1194/jlr.R500013-JLR200
   Roberfroid M, 2002, DIGEST LIVER DIS, V34, pS105, DOI 10.1016/S1590-8658(02)80176-1
   Roger LC, 2010, MICROBIOL-SGM, V156, P3329, DOI 10.1099/mic.0.043224-0
   Rupérez AI, 2014, INT J MOL SCI, V15, P3118, DOI 10.3390/ijms15023118
   Sah SP, 2011, INDIAN J PHARMACOL, V43, P192, DOI 10.4103/0253-7613.77365
   Sanchez-Villegas A, 2013, BMC MED, V11, DOI [10.1186/1741-7015-11-3, 10.1186/1741-7015-11-208]
   Sarris J, 2015, LANCET PSYCHIAT, V2, P271, DOI 10.1016/S2215-0366(14)00051-0
   Saulnier DM, 2011, GASTROENTEROLOGY, V141, P1782, DOI 10.1053/j.gastro.2011.06.072
   Shen W, 2014, J NUTR, V144, P1181, DOI 10.3945/jn.114.194332
   Slyepchenko A, 2016, NEUROSCI BIOBEHAV R, V64, P83, DOI 10.1016/j.neubiorev.2016.02.002
   Slyepchenko A, 2014, CNS NEUROL DISORD-DR, V13, P1770
   Song YL, 2006, INT J SYST EVOL MICR, V56, P1985, DOI 10.1099/ijs.0.64318-0
   Spranger J, 2003, DIABETES, V52, P812, DOI 10.2337/diabetes.52.3.812
   Steenbergen L, 2015, BRAIN BEHAV IMMUN, V48, P258, DOI 10.1016/j.bbi.2015.04.003
   Stetler C, 2011, PSYCHOSOM MED, V73, P114, DOI 10.1097/PSY.0b013e31820ad12b
   Stokes PE, 1995, EUR NEUROPSYCHOPHARM, V5, P77, DOI 10.1016/0924-977X(95)00039-R
   Sun J, 2015, ANN MED, V47, P430, DOI 10.3109/07853890.2015.1071872
   Tazoe H, 2008, J PHYSIOL PHARMACOL, V59, P251
   Thompson WG, 2000, GUT, V46, P78, DOI 10.1136/gut.46.1.78
   Tsigos C, 1999, METABOLISM, V48, P1332, DOI 10.1016/S0026-0495(99)90277-9
   Turnbaugh PJ, 2012, NATURE, V487, P47, DOI 10.1038/487047a
   Tyagi E, 2010, EUR J PHARMACOL, V640, P206, DOI 10.1016/j.ejphar.2010.04.041
   Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
   Vancampfort D, 2015, DEPRESS ANXIETY, V32, P763, DOI 10.1002/da.22387
   VanderJagt DJ, 2001, CLIN BIOCHEM, V34, P265, DOI 10.1016/S0009-9120(01)00204-1
   Walker AW, 2005, APPL ENVIRON MICROB, V71, P3692, DOI 10.1128/AEM.71.7.3692-3700.2005
   Whitehead WE, 2002, GASTROENTEROLOGY, V122, P1140, DOI 10.1053/gast.2002.32392
   WHORWELL PJ, 1987, GUT, V28, P423, DOI 10.1136/gut.28.4.423
   Wiest R, 2005, HEPATOLOGY, V41, P422, DOI 10.1002/hep.20632
   Wischmeyer PE, 2006, CURR OPIN CLIN NUTR, V9, P607, DOI 10.1097/01.mco.0000241672.09676.03
   Wu GD, 2011, SCIENCE, V334, P105, DOI 10.1126/science.1208344
   Wu M, 2015, SCIENCE, V350, DOI 10.1126/science.aac5992
   Yoo JY, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030173
   Yu YB, 2012, GUT, V61, P685, DOI 10.1136/gutjnl-2011-300265
   Zhang CH, 2012, ISME J, V6, P1848, DOI 10.1038/ismej.2012.27
   Zhang XY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071108
   Zheng P, 2016, MOL PSYCHIATR, V21, P786, DOI 10.1038/mp.2016.44
   Zhou QQ, 2009, PAIN, V146, P41, DOI 10.1016/j.pain.2009.06.017
NR 204
TC 181
Z9 198
U1 0
U2 138
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0033-3190
EI 1423-0348
J9 PSYCHOTHER PSYCHOSOM
JI Psychother. Psychosom.
PY 2017
VL 86
IS 1
BP 31
EP 46
DI 10.1159/000448957
PG 16
WC Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA EF1KL
UT WOS:000390083600005
PM 27884012
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Torghabeh, FD
   Javadi, B
   Sahebkar, A
AF Torghabeh, Fatemeh Dehbashizadeh
   Javadi, Behjat
   Sahebkar, Amirhossein
TI Dietary anethole: a systematic review of its protective effects against
   metabolic syndrome
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Review
DE Metabolic syndrome; Dietary anethole; Obesity; Diabetes; Dyslipidemia;
   Systematic review
ID TRANS-ANETHOLE; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; HYPERTENSION; IMPACT
AB BackgroundMetabolic syndrome (MetS) is a cluster of physiological, biochemical, clinical, and metabolic conditions that aggravate the risk of severe diseases such as cardiovascular disease, type 2 diabetes mellitus, and fatty liver. Several dietary molecules have been considered preventive compounds for MetS. Anethole, a natural phenylpropanoid, has been found to protect against MetS and its associated components.AimThis systematic review aims to provide an overview of the preclinical evidence supporting the protective effects of dietary anethole against MetS and the associated diseases.MethodsA literature search was performed using Web of Sciences, PubMed, Scopus, and Google Scholar to identify studies reporting the protective effects of dietary anethole against MetS, without any time restrictions. Review articles, letters to editors, editorials, unpublished results, and non-English papers were excluded from the study.ResultsThe results showed that anethole has the potential to effectively protect against the key features of MetS via various mechanisms, including antioxidant and anti-inflammatory effects, stimulating insulin secretion from beta-cells, mediating oxidative stress, modulation of the mTOR/PPAR gamma axis, arterial remodeling, and improvement of vascular relaxation.ConclusionAnethole modulates several molecular pathways that are implicated in the pathogenesis of MetS. Future in vitro and animal investigations should be conducted to explore other anti-MetS signaling pathways of anethole. Additionally, well-designed clinical studies are warranted to determine the optimal human dose, bioavailability, and pharmacokinetic characteristics of this dietary compound.
C1 [Torghabeh, Fatemeh Dehbashizadeh; Javadi, Behjat] Mashhad Univ Med Sci, Sch Pharm, Dept Tradit Pharm, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
EM amir_saheb2000@yahoo.com
RI Sahebkar, Amirhossein/B-5124-2018; Javadi, Behjat/AAC-5468-2020
FU Research Council of Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences
FX The authors would like to thank Mashhad University of Medical Sciences
   for supporting the present study.
CR Afshari AR, 2021, CURR MED CHEM, V28, P377, DOI 10.2174/0929867327666200130104757
   Ahad A, 2016, PHARM BIOL, V54, P1042, DOI 10.3109/13880209.2015.1100639
   Ahmadi A, 2022, PHARMACOL RES, V184, DOI 10.1016/j.phrs.2022.106414
   Aprotosoaie AC, 2016, ADV EXP MED BIOL, V929, P247, DOI 10.1007/978-3-319-41342-6_11
   Balan Y, 2022, ARCH MED SCI, V18, P459, DOI 10.5114/aoms.2020.96344
   Bielecka-Dabrowa A, 2023, ARCH MED SCI, V19, P841, DOI 10.5114/aoms/167799
   Black PH, 2003, BRAIN BEHAV IMMUN, V17, P350, DOI 10.1016/S0889-1591(03)00048-5
   Bounds SV, 1996, DRUG METAB DISPOS, V24, P717
   Carratù B, 2010, ANN I SUPER SANITA, V46, P370, DOI 10.4415/ANN_10_04_05
   Das UN, 2004, CURR HYPERTENS REP, V6, P66, DOI 10.1007/s11906-004-0014-8
   Derosa G, 2018, J CELL PHYSIOL, V233, P153, DOI 10.1002/jcp.25804
   Dobrowolski P, 2022, ARTER HYPERTENS, V26, DOI [10.5603/AH.a2022.0012, 10.5114/aoms/152921]
   Dongare V, 2012, FOOD CHEM, V132, P385, DOI 10.1016/j.foodchem.2011.11.005
   Enayati A, 2022, BIOMED PHARMACOTHER, P146
   Enayati A, 2021, CURR MED CHEM, V28, P1197, DOI 10.2174/0929867327666200505084620
   Fève B, 2009, NAT REV ENDOCRINOL, V5, P305, DOI 10.1038/nrendo.2009.62
   Ghaderi MA, MINI-REV MED CHEM
   Gutch Manish, 2015, Indian J Endocrinol Metab, V19, P160, DOI 10.4103/2230-8210.146874
   Hosseini A, 2021, CURR MED CHEM, V28, P8595, DOI 10.2174/0929867328666210614113116
   Hosseini SA, 2021, BIOFACTORS, V47, P250, DOI 10.1002/biof.1713
   Hussain MF, 2020, FEBS J, V287, P3370, DOI 10.1111/febs.15331
   Iranshahy M, 2022, PHYTOTHER RES, V36, P1952, DOI 10.1002/ptr.7425
   Jafari F, 2022, J ETHNOPHARMACOL, V294, DOI 10.1016/j.jep.2022.115340
   Kang NH, 2018, BIOCHIMIE, V151, P1, DOI 10.1016/j.biochi.2018.05.009
   Kilkenny C, 2010, PLOS BIOL, V8, DOI 10.1371/journal.pbio.1000412
   Kim KY, 2017, BIOMED PHARMACOTHER, V91, P925, DOI 10.1016/j.biopha.2017.05.032
   Kumar AS, 2019, ANN PHYS REHABIL MED, V62, P98, DOI 10.1016/j.rehab.2018.11.001
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lukic L, 2014, INT J ENV RES PUB HE, V11, P3586, DOI 10.3390/ijerph110403586
   Marinov V., 2015, Scr Sci Pharm, V2, P14
   Matboli M, 2022, BIOMED PHARMACOTHER, V150, DOI 10.1016/j.biopha.2022.113070
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   Meigs JB, 2007, DIABETES CARE, V30, P1219, DOI 10.2337/dc06-2484
   Mokhtari-Zaer A, 2019, J CELL PHYSIOL, V234, P214, DOI 10.1002/jcp.26848
   Newberne P, 1999, FOOD CHEM TOXICOL, V37, P789, DOI 10.1016/S0278-6915(99)00037-X
   Otani H, 2011, ANTIOXID REDOX SIGN, V15, P1911, DOI 10.1089/ars.2010.3739
   Park SK, 2020, CANCER-AM CANCER SOC, V126, P1979, DOI 10.1002/cncr.32737
   Petan T, 2018, MOLECULES, V23, DOI 10.3390/molecules23081941
   Razavi BM, 2014, J ENDOCRINOL INVEST, V37, P1031, DOI 10.1007/s40618-014-0150-1
   Rezazadeh L, 2021, CLIN NUTR ESPEN, V41, P136, DOI 10.1016/j.clnesp.2020.12.003
   Rhee YH, 2018, BMC CELL BIOL, V19, DOI 10.1186/s12860-018-0163-2
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Rodríguez-Hernández H, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/678159
   Roubenne L., 2021, REV MAL RESPIR, V38, P582, DOI [10.1016/j.rmr.2021.02.030, DOI 10.1016/J.RMR.2021.02.030]
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Samadi-Noshahr Z, 2021, FOOD SCI NUTR, V9, P1121, DOI 10.1002/fsn3.2090
   Sarbijani HM, 2016, DIABETES METAB SYND, V10, pS86, DOI 10.1016/j.dsx.2015.09.024
   Seo E, 2018, BIOMED PHARMACOTHER, V102, P249, DOI 10.1016/j.biopha.2018.03.081
   Shahbodi M, 2022, CELL BIOCHEM BIOPHYS, V80, P771, DOI 10.1007/s12013-022-01095-z
   Sheikh BA, 2015, BIOCHIMIE, V112, P57, DOI 10.1016/j.biochi.2015.02.008
   Soltani F, 2021, S AFR J BOT, V140, P11, DOI 10.1016/j.sajb.2021.03.029
   Song AR, 2020, MOLECULES, V25, DOI 10.3390/molecules25214946
   Tawfik MK, 2023, ARCH MED SCI, V19, P1508, DOI 10.5114/aoms/158534
   Ulrey A, 2021, ALTEX-ALTERN ANIM EX, V38, P316, DOI 10.14573/altex.2102261
   Younis NS, 2022, CHEM-BIOL INTERACT, V360, DOI 10.1016/j.cbi.2022.109947
   Yu CY, 2021, POULTRY SCI, V100, DOI 10.1016/j.psj.2021.101484
   Zafar U, 2018, HORM-INT J ENDOCRINO, V17, P299, DOI 10.1007/s42000-018-0051-3
   Zhang CC, 2022, CLIN RES HEPATOL GAS, V46, DOI 10.1016/j.clinre.2021.101833
   Zhao C, 2020, BIORXIV
NR 59
TC 3
Z9 3
U1 0
U2 3
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD JUN
PY 2024
VL 23
IS 1
BP 619
EP 631
DI 10.1007/s40200-023-01322-1
EA DEC 2023
PG 13
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA I8H6K
UT WOS:001131885500001
PM 38932801
DA 2025-06-11
ER

PT J
AU Reverri, EJ
   Randolph, JM
   Steinberg, FM
   Kappagoda, CT
   Edirisinghe, I
   Burton-Freeman, BM
AF Reverri, Elizabeth J.
   Randolph, Jody M.
   Steinberg, Francene M.
   Kappagoda, C. Tissa
   Edirisinghe, Indika
   Burton-Freeman, Britt M.
TI Black Beans, Fiber, and Antioxidant Capacity Pilot Study: Examination of
   Whole Foods vs. Functional Components on Postprandial Metabolic,
   Oxidative Stress, and Inflammation in Adults with Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
ID HIGH-FAT; NONFASTING TRIGLYCERIDES; HEART-DISEASE; ENDOTHELIAL FUNCTION;
   INSULIN SENSITIVITY; PHASEOLUS-VULGARIS; HIGH-CARBOHYDRATE;
   HEALTHY-SUBJECTS; DIETARY FIBER; OLIVE OIL
AB Beans (Phaseolus vulgaris) contain bioactive components with functional properties that may modify cardiovascular risk. The aims of this pilot study were to evaluate the ability of black beans to attenuate postprandial metabolic, oxidative stress, and inflammatory responses and determine relative contribution of dietary fiber and antioxidant capacity of beans to the overall effect. In this randomized, controlled, crossover trial, 12 adults with metabolic syndrome (MetS) consumed one of three meals (black bean (BB), fiber matched (FM), and antioxidant capacity matched (AM)) on three occasions that included blood collection before (fasting) and five hours postprandially. Insulin was lower after the BB meal, compared to the FM or AM meals (p < 0.0001). A significant meal x time interaction was observed for plasma antioxidant capacity (p = 0.002) revealing differences over time: AM > BB > FM. Oxidized LDL (oxLDL) was not different by meal, although a trend for declining oxLDL was observed after the BB and AM meals at five hours compared to the FM meal. Triglycerides and interleukin-6 (IL-6) increased in response to meals (p < 0.0001). Inclusion of black beans with a typical Western-style meal attenuates postprandial insulin and moderately enhances postprandial antioxidant endpoints in adults with MetS, which could only be partly explained by fiber content and properties of antioxidant capacity.
C1 [Reverri, Elizabeth J.; Randolph, Jody M.; Steinberg, Francene M.; Burton-Freeman, Britt M.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Kappagoda, C. Tissa] Univ Calif Davis, Davis Hlth Syst, Lawrence J Ellis Ambulatory Care Ctr, Dept Cardiovasc Med, Sacramento, CA 95817 USA.
   [Kappagoda, C. Tissa] Univ Calif Davis, Davis Hlth Syst, Lawrence J Ellis Ambulatory Care Ctr, Dept Cardiol, Sacramento, CA 95817 USA.
   [Kappagoda, C. Tissa] Univ Calif Davis, Davis Hlth Syst, Lawrence J Ellis Ambulatory Care Ctr, Dept Internal Med, Sacramento, CA 95817 USA.
   [Edirisinghe, Indika; Burton-Freeman, Britt M.] IIT, Inst Food Safety & Hlth, Ctr Nutr Res, Bedford Pk, IL 60501 USA.
C3 University of California System; University of California Davis;
   University of California System; University of California Davis;
   University of California System; University of California Davis;
   University of California System; University of California Davis;
   Illinois Institute of Technology
RP Burton-Freeman, BM (corresponding author), Univ Calif Davis, Dept Nutr, One Shields Ave, Davis, CA 95616 USA.
EM ebjordan@ucdavis.edu; jmrandolph@ucdavis.edu; fmsteinberg@ucdavis.edu;
   iedirisi@iit.edu; bburton@iit.edu
RI Reverri, Elizabeth/H-3840-2014
OI Reverri, Elizabeth/0000-0001-7692-0901
FU USDA Agricultural Research Service (CRIS) [CA-D*NTR-6316-H]; UC Davis
   Jastro Research Award [GGNBEJ3]; US Dry Bean Council
FX Study funding was provided by the USDA Agricultural Research Service
   (CRIS # CA-D*NTR-6316-H), UC Davis Jastro Research Award (grant number
   GGNBEJ3), and US Dry Bean Council. Polyphenolics donated GSE lot
   20392508-1.
CR Bansal S, 2007, JAMA-J AM MED ASSOC, V298, P309, DOI 10.1001/jama.298.3.309
   Blacker BC, 2013, BRIT J NUTR, V109, P1670, DOI 10.1017/S0007114512003650
   Bohn T, 2014, NUTR REV, V72, P429, DOI 10.1111/nure.12114
   Bourdon I, 2001, J NUTR, V131, P1485, DOI 10.1093/jn/131.5.1485
   Burton-Freeman B, 2012, MOL NUTR FOOD RES, V56, P622, DOI 10.1002/mnfr.201100649
   Burton-Freeman B, 2010, J AM COLL NUTR, V29, P46, DOI 10.1080/07315724.2010.10719816
   Chusak C, 2014, AM J CHINESE MED, V42, P315, DOI 10.1142/S0192415X14500219
   Cortés B, 2006, J AM COLL CARDIOL, V48, P1666, DOI 10.1016/j.jacc.2006.06.057
   Cox-York KA, 2013, METABOLISM, V62, P244, DOI 10.1016/j.metabol.2012.08.003
   Devaraj S, 2008, METABOLISM, V57, P867, DOI 10.1016/j.metabol.2008.02.016
   Edirisinghe I, 2012, FUNCT FOODS HEALTH D, V2, P508, DOI 10.31989/ffhd.v2i12.68
   Edirisinghe I, 2011, BRIT J NUTR, V106, P913, DOI 10.1017/S0007114511001176
   Esposito K, 2003, AM J CLIN NUTR, V78, P1135, DOI 10.1093/ajcn/78.6.1135
   Fuentes F, 2008, BRIT J NUTR, V100, P159, DOI 10.1017/S0007114508888708
   Go AS, 2014, CIRCULATION, V129, pE28, DOI 10.1161/01.cir.0000441139.02102.80
   Haddad EH, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-4
   Herieka M, 2014, MOL NUTR FOOD RES, V58, P136, DOI 10.1002/mnfr.201300104
   Hudthagosol C, 2011, J NUTR, V141, P56, DOI 10.3945/jn.110.121269
   Hutchins AM, 2012, BRIT J NUTR, V108, pS52, DOI 10.1017/S0007114512000761
   Jackson KG, 2012, ATHEROSCLEROSIS, V220, P22, DOI 10.1016/j.atherosclerosis.2011.08.012
   Jefferis BJMH, 2011, ATHEROSCLEROSIS, V217, P227, DOI 10.1016/j.atherosclerosis.2011.03.015
   Jennings A, 2014, J NUTR, V144, P202, DOI 10.3945/jn.113.184358
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   Kay CD, 2002, BRIT J NUTR, V88, P389, DOI 10.1079/BJN2002665
   Kolovou GD, 2006, EUR J CARDIOV PREV R, V13, P661, DOI 10.1097/01.hjr.0000224490.10845.26
   Lairon D, 2007, EUR J CLIN NUTR, V61, P1145, DOI 10.1038/sj.ejcn.1602749
   Lairon D, 2007, J NUTR BIOCHEM, V18, P217, DOI 10.1016/j.jnutbio.2006.08.001
   Li D, 2015, J NUTR, V145, P742, DOI 10.3945/jn.114.205674
   Lindman AS, 2010, EUR J EPIDEMIOL, V25, P789, DOI 10.1007/s10654-010-9501-1
   Lutsey PL, 2008, CIRCULATION, V117, P754, DOI 10.1161/CIRCULATIONAHA.107.716159
   Marathe SA, 2011, FOOD CHEM TOXICOL, V49, P2005, DOI 10.1016/j.fct.2011.04.039
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McCleary BV, 2012, J AOAC INT, V95, P824, DOI 10.5740/jaoacint.CS2011_25
   Messina V, 2014, AM J CLIN NUTR, V100, p437S, DOI 10.3945/ajcn.113.071472
   Miglio C, 2013, EUR J NUTR, V52, P1107, DOI 10.1007/s00394-012-0420-7
   Nappo F, 2002, J AM COLL CARDIOL, V39, P1145, DOI 10.1016/S0735-1097(02)01741-2
   Neri S, 2010, EUR J NUTR, V49, P409, DOI 10.1007/s00394-010-0099-6
   Nilsson A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059985
   Nordestgaard BG, 2007, JAMA-J AM MED ASSOC, V298, P299, DOI 10.1001/jama.298.3.299
   Oda E, 2012, ACTA DIABETOL, V49, P89, DOI 10.1007/s00592-011-0309-6
   Olmedilla-Alonso B, 2013, J SCI FOOD AGR, V93, P1076, DOI 10.1002/jsfa.5852
   Pachco YA, 2008, J NUTR BIOCHEM, V19, P200, DOI 10.1016/j.jnutbio.2007.03.002
   Payette C, 2009, METABOLISM, V58, P1593, DOI 10.1016/j.metabol.2009.05.011
   Perez-Martinez P, 2010, ATHEROSCLEROSIS, V209, P533, DOI 10.1016/j.atherosclerosis.2009.09.023
   Prior RL, 2003, J AGR FOOD CHEM, V51, P3273, DOI 10.1021/jf0262256
   Prior RL, 2007, J AM COLL NUTR, V26, P170, DOI 10.1080/07315724.2007.10719599
   Skulas-Ray AC, 2011, J NUTR, V141, P1451, DOI 10.3945/jn.111.138966
   Snyder SM, 2011, NUTR RES, V31, P519, DOI 10.1016/j.nutres.2011.06.006
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Spadafranca A, 2013, BRIT J NUTR, V109, P1789, DOI 10.1017/S0007114512003741
   Stull AJ, 2010, J NUTR, V140, P1764, DOI 10.3945/jn.110.125336
   Thompson SV, 2012, NUTR J, V11, DOI 10.1186/1475-2891-11-23
   Troseid M, 2010, CARDIOVASC DIABETOL, V9, DOI 10.1186/1475-2840-9-11
   Williamson G, 2013, MOL NUTR FOOD RES, V57, P48, DOI 10.1002/mnfr.201200511
   Winham DM, 2007, J AM COLL NUTR, V26, P243, DOI 10.1080/07315724.2007.10719607
   Wu XL, 2006, J AGR FOOD CHEM, V54, P4069, DOI 10.1021/jf060300l
   Zhao Y, 2014, FOOD CHEM, V152, P462, DOI 10.1016/j.foodchem.2013.12.006
NR 57
TC 50
Z9 52
U1 1
U2 33
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2015
VL 7
IS 8
BP 6139
EP 6154
DI 10.3390/nu7085273
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CQ4PQ
UT WOS:000360587500006
PM 26225995
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Kyrou, L
   Tsigos, C
AF Kyrou, Loannis
   Tsigos, Constantine
TI Chronic stress, visceral obesity and gonadal dysfunction
SO HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE Abdominal obesity; Adipokines; Gonads; Hypogonadism;
   Hypothalamic-pituitary-adrenal axis; Obesity; Sex-steroids; Stress
ID RECOMBINANT HUMAN INTERLEUKIN-6; HORMONE GENE-EXPRESSION;
   NECROSIS-FACTOR-ALPHA; ADIPOSE-TISSUE; METABOLIC SYNDROME; LEPTIN;
   REPRODUCTION; INFLAMMATION; IMPACT; ENDOCRINOLOGY
AB Chronic stress represents a prolonged state of dyshomeostasis caused by intense and frequently imposed stressors. Obesity constitutes a chronic dysmetabolic state, leading progressively to a spectrum of metabolic complications, such as diabetes, dyslipidemia, hypertension and cardiovascular disease. A growing body of evidence supports the existence of significant interactions between stress and obesity, with chronic stress promoting weight gain, and consequently excessive fat accumulation especially visceral, all these factors contributing to the development of a chronic stressful state. Maintaining body homeostasis is a prerequisite for normal reproductive function, which is vital for the survival of the species and an important process of natural selection. Under chronic stress, reproductive function is suspended and disrupted due to central and peripheral actions of hormones, adipokines and pro-inflammatory cytokines that inhibit the activity of the hypothalamic-pituitary gonadal (HPG) axis at various levels. Clinical and experimental data link both obesity and chronic stress to dysregulation of the gonadal axis, via independent and synergistic mechanisms, which may chronically lead to reproductive dysfunction and reduced fertility.
C1 [Kyrou, Loannis; Tsigos, Constantine] Univ Athens, Sch Med, Evgenid Hosp, Endocrinol Metab & Diabet Unit, GR-11527 Athens, Greece.
   [Kyrou, Loannis] Univ Warwick, Warwick Med Sch, Univ Hosp Coventry, WISDEM,Unit Diabet & Metab, Coventry CV4 7AL, W Midlands, England.
   [Kyrou, Loannis] Univ Warwick, Warwick Med Sch, Univ Hosp Warwickshire, WISDEM,Unit Diabet & Metab, Coventry CV4 7AL, W Midlands, England.
C3 Athens Medical School; National & Kapodistrian University of Athens;
   University of Warwick; University of Warwick
RP Tsigos, C (corresponding author), 82 Vas Sophias Ave, GR-11528 Athens, Greece.
EM ctsigos@gmail.com
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Balen Adam H, 2007, Hum Fertil (Camb), V10, P195, DOI 10.1080/14647270701731290
   BLOHER S, 2007, CURR OPIN ENDOCRINOL, V14, P458
   Bray George A., 1997, Human Reproduction (Oxford), V12, P26
   Brunner EJ, 2007, AM J EPIDEMIOL, V165, P828, DOI 10.1093/aje/kwk058
   Cavagnini F, 2000, INT J OBESITY, V24, pS77, DOI 10.1038/sj.ijo.0801284
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Charmandari E, 2005, ANNU REV PHYSIOL, V67, P259, DOI 10.1146/annurev.physiol.67.040403.120816
   Chrousos George P., 1998, Annals of Internal Medicine, V129, P229
   Chrousos GP, 2007, SLEEP MED CLIN, V2, P125, DOI 10.1016/j.jsmc.2007.04.004
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   CHROUSOS GP, 1992, JAMA-J AM MED ASSOC, V267, P1244, DOI 10.1001/jama.267.9.1244
   Dallman MF, 2006, PROG BRAIN RES, V153, P75, DOI 10.1016/S0079-6123(06)53004-3
   Dallman MF, 2003, P NATL ACAD SCI USA, V100, P11696, DOI 10.1073/pnas.1934666100
   Fischer-Posovszky P, 2007, HORM METAB RES, V39, P314, DOI 10.1055/s-2007-976539
   Gao Q, 2008, AM J PHYSIOL-ENDOC M, V294, pE817, DOI 10.1152/ajpendo.00733.2007
   Goulis DG, 2008, GYNECOL ENDOCRINOL, V24, P33, DOI 10.1080/09513590701582273
   Haffner SM, 2000, INT J OBESITY, V24, pS56, DOI 10.1038/sj.ijo.0801279
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   HOTAMISLIGIL GS, 1994, DIABETES, V43, P1271, DOI 10.2337/diabetes.43.11.1271
   Kalra SP, 1999, ENDOCR REV, V20, P68, DOI 10.1210/er.20.1.68
   KAYE WH, 1990, ARCH GEN PSYCHIAT, V47, P548
   Kokkoris P, 2003, ENDOCRIN METAB CLIN, V32, P895, DOI 10.1016/S0889-8529(03)00078-1
   Kyrou I, 2007, HORM METAB RES, V39, P430, DOI 10.1055/s-2007-981462
   Kyrou I, 2006, ANN NY ACAD SCI, V1083, P77, DOI 10.1196/annals.1367.008
   Lado-Abeal J, 2002, SEMIN REPROD MED, V20, P145, DOI 10.1055/s-2002-32506
   Lee CMY, 2008, J CLIN EPIDEMIOL, V61, P646, DOI 10.1016/j.jclinepi.2007.08.012
   LUGER A, 1987, NEW ENGL J MED, V316, P1309, DOI 10.1056/NEJM198705213162105
   MACCONNIE SE, 1986, NEW ENGL J MED, V315, P411, DOI 10.1056/NEJM198608143150702
   Margetic S, 2002, INT J OBESITY, V26, P1407, DOI 10.1038/sj.ijo.0802142
   Metwally M, 2007, OBES REV, V8, P515, DOI 10.1111/j.1467-789X.2007.00406.x
   Mitchell M, 2005, REPRODUCTION, V130, P583, DOI 10.1530/rep.1.00521
   Nelson SM, 2007, CURR OPIN OBSTET GYN, V19, P384, DOI 10.1097/GCO.0b013e32825e1d70
   Nestler JE, 2000, INT J OBESITY, V24, pS71, DOI 10.1038/sj.ijo.0801282
   Norman RJ, 1998, REPROD FERT DEVELOP, V10, P55, DOI 10.1071/R98010
   Pasquali R, 2002, J ENDOCRINOL INVEST, V25, P893, DOI 10.1007/BF03344053
   Pasquali Renato, 2007, Curr Opin Endocrinol Diabetes Obes, V14, P482, DOI 10.1097/MED.0b013e3282f1d6cb
   RABIN DS, 1990, J CLIN ENDOCR METAB, V71, P1158, DOI 10.1210/jcem-71-5-1158
   RIVIER C, 1986, SCIENCE, V231, P607, DOI 10.1126/science.3003907
   Scherer PE, 2006, DIABETES, V55, P1537, DOI 10.2337/db06-0263
   Snijder MB, 2004, INT J OBESITY, V28, P402, DOI 10.1038/sj.ijo.0802567
   Tchernof A, 2000, HORM METAB RES, V32, P526, DOI 10.1055/s-2007-978681
   Tena-Sempere M, 2002, MOL CELL ENDOCRINOL, V188, P9, DOI 10.1016/S0303-7207(02)00008-4
   Torres SJ, 2007, NUTRITION, V23, P887, DOI 10.1016/j.nut.2007.08.008
   Trayhurn P, 2004, BRIT J NUTR, V92, P347, DOI 10.1079/BJN20041213
   Trujillo ME, 2006, ENDOCR REV, V27, P798, DOI 10.1210/er.2006-0033
   Tsigos C, 1999, J INTERF CYTOK RES, V19, P1271, DOI 10.1089/107999099312948
   Tsigos C, 1999, METABOLISM, V48, P1332, DOI 10.1016/S0026-0495(99)90277-9
   Tsigos C, 1997, J CLIN ENDOCR METAB, V82, P4167, DOI 10.1210/jc.82.12.4167
   Tsigos C, 2002, J PSYCHOSOM RES, V53, P865, DOI 10.1016/S0022-3999(02)00429-4
   VAMVAKOPOULOS NC, 1993, J CLIN INVEST, V92, P1896, DOI 10.1172/JCI116782
   VAMVAKOPOULOS NC, 1994, ENDOCR REV, V15, P409, DOI 10.1210/er.15.4.409
   Yudkin JS, 2007, HORM METAB RES, V39, P707, DOI 10.1055/s-2007-985898
NR 53
TC 47
Z9 53
U1 0
U2 11
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1109-3099
EI 2520-8721
J9 HORM-INT J ENDOCRINO
JI Horm.-Int. J. Endocrinol. Metab.
PD OCT-DEC
PY 2008
VL 7
IS 4
BP 287
EP 293
DI 10.14310/horm.2002.1209
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 381VU
UT WOS:000261564800001
PM 19121989
OA Bronze
DA 2025-06-11
ER

PT J
AU Quesada, I
   Cejas, J
   García, R
   Cannizzo, B
   Redondo, A
   Castro, C
AF Quesada, Isabel
   Cejas, Jimena
   Garcia, Rodrigo
   Cannizzo, Beatriz
   Redondo, Analia
   Castro, Claudia
TI Vascular dysfunction elicited by a cross talk between periaortic adipose
   tissue and the vascular wall is reversed by pioglitazone
SO CARDIOVASCULAR THERAPEUTICS
LA English
DT Article
DE adipose tissue; atherosclerosis; oxidative stress; pioglitazone
ID PROLIFERATOR-ACTIVATED RECEPTOR; TYPE-2 DIABETES-MELLITUS; NADPH OXIDASE
   ACTIVITY; ENDOTHELIAL DYSFUNCTION; PPAR-GAMMA; CAROTID ATHEROSCLEROSIS;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS
AB Aim: Perivascular adipose tissue (PVAT) is in intimate contact with the vessel wall and extravascular PVAT-derived inflammatory mediators may adversely influence atherosclerotic plaque formation and stability through outside-to-inside signaling. We sought to investigate the role of PVAT on the atheroma development in an experimental animal model of metabolic syndrome (MS) associated with oxidative stress and low-grade inflammatory state. We also studied the effect of pioglitazone an insulin sensitizer, on the aortic wall and its surrounding PVAT, considering a bi-directional communication between both layers.
   Methods: Apolipoprotein E-deficient mice (ApoE(-/-)) were fed with standard diet (CD, control diet) or fructose overload (10% w/v) (FD, fructose diet) for 8weeks and treated with or without pioglitazone the latest 4weeks.
   Results: Biochemical variables show that glycemia and lipid peroxidation determined by thiobarbituric acid reactive species (TBARS) significantly increased in FD-fed ApoE(-/-) mice. FD significantly increased aortic PVAT expression of oxidative stress associated genes: p22(phox), Nox1, Nox2, Nox4 and p47(phox), and proinflammatory genes: Visfatin, MCP-1, and MMP-9. Pioglitazone diminished PVAT-oxidative damage elicited by fructose treatment and markedly down-regulated proinflammatory markers. Even pioglitazone did not prevent the development of the aortic atheroma plaques stimulated by FD, significantly diminished VCAM-1 expression, MMP-9 expression and activity in aortic media wall and significantly reduced the accumulation of lipids and macrophages in atheroma plaques.
   Conclusion: Our results support the fact that PVAT contributes to the development and progression of cardiovascular disease by underlying mechanisms elicited by outside-in signaling. Treatment with pioglitazone may offer a new effect on the whole vessel wall, promoting the stability of advanced atherosclerotic plaques.
C1 [Quesada, Isabel; Cejas, Jimena; Cannizzo, Beatriz; Redondo, Analia; Castro, Claudia] Natl Univ Cuyo, Vasc Biol Lab, Inst Expt Med & Biol Cuyo IMBECU, CONICET,Sch Med Sci, Mendoza, Argentina.
   [Garcia, Rodrigo] Consejo Nacl Invest Cient & Tecn, Lab Cardiovasc Physiopathol, Inst Expt Med & Biol Cuyo IMBECU, Mendoza, Argentina.
   [Cannizzo, Beatriz] Genzyme Argentina AS, Boulogne, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   Instituto de Medicina y BiologIa Experimental de Cuyo (IMBECU);
   University Nacional Cuyo Mendoza; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Instituto de Medicina y BiologIa
   Experimental de Cuyo (IMBECU)
RP Castro, C (corresponding author), Consejo Nacl Invest Cient & Tecn, Inst Expt Med & Biol Cuyo IMBECU, Mendoza, Argentina.
EM ccastro@fcm.uncu.edu.ar
RI GARCIA, RODRIGO DAMIAN/IUN-1823-2023
OI Castro, Claudia/0000-0002-8428-2484; Garcia, Rodrigo
   Damian/0000-0002-6654-214X
FU Secretary of Science and Technology [06/J431]; National University of
   Cuyo; PIP-CONICET; CONICET
FX This work was supported by grant 06/J431 2013-2015 from Secretary of
   Science and Technology, National University of Cuyo, and PIP-CONICET
   2012-2014 (to C Castro). JC is a recipient of a fellowship from National
   University of Cuyo and RG, BC, and AR were granted by a doctoral
   fellowship from CONICET.
CR Abu Bakar H, 2017, CARDIOVASC RES, V113, P962, DOI 10.1093/cvr/cvx062
   Antonopoulos AS, 2017, SCI TRANSL MED, V9, DOI 10.1126/scitranslmed.aal2658
   Antonopoulos AS, 2015, DIABETES, V64, P2207, DOI 10.2337/db14-1011
   Bril F, 2017, DIABETES CARE, V40, P419, DOI 10.2337/dc16-1787
   Brown NK, 2014, ARTERIOSCL THROM VAS, V34, P1621, DOI 10.1161/ATVBAHA.114.303029
   Cannizzo B, 2014, FREE RADICAL RES, V48, P526, DOI 10.3109/10715762.2014.889295
   Cannizzo B, 2012, EXP DIABETES RES, DOI 10.1155/2012/941304
   Cejková S, 2017, PHYSIOL RES, V66, P633, DOI 10.33549/physiolres.933352
   Chang K, 2010, ARTERIOSCL THROM VAS, V30, P1933, DOI 10.1161/ATVBAHA.110.206342
   Cornier MA, 2008, ENDOCR REV, V29, P777, DOI 10.1210/er.2008-0024
   Dolezalová R, 2007, PHYSIOL RES, V56, P741, DOI 10.33549/physiolres.931060
   Even SEL, 2014, HORM MOL BIOL CLIN I, V19, P89, DOI 10.1515/hmbci-2014-0013
   Forst T, 2011, EXPERT OPIN PHARMACO, V12, P1571, DOI 10.1517/14656566.2011.567266
   Fuster JJ, 2016, CIRC RES, V118, P1786, DOI 10.1161/CIRCRESAHA.115.306885
   Galili O, 2007, AM J PHYSIOL-HEART C, V292, pH904, DOI 10.1152/ajpheart.00628.2006
   Gastaldelli A, 2009, HEPATOLOGY, V50, P1087, DOI 10.1002/hep.23116
   Gu P, 2013, REV ENDOCR METAB DIS, V14, P49, DOI 10.1007/s11154-012-9230-8
   Hulsmans M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0062253
   Jiang CY, 1998, NATURE, V391, P82, DOI 10.1038/34184
   Ketonen J, 2010, CIRC J, V74, P1479, DOI 10.1253/circj.CJ-09-0661
   Kintscher U, 2000, EUR J PHARMACOL, V401, P259, DOI 10.1016/S0014-2999(00)00461-1
   Kong X, 2014, J RENIN-ANGIO-ALDO S, V15, P259, DOI 10.1177/1470320313489061
   Kralisch S, 2007, Minerva Endocrinol, V32, P161
   Lastra G, 2015, HORM MOL BIOL CLIN I, V22, P19, DOI 10.1515/hmbci-2015-0010
   Liu SW, 2009, CLIN ENDOCRINOL, V71, P202, DOI 10.1111/j.1365-2265.2008.03453.x
   Liu XL, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033497
   Molshanski-Mor Shahar, 2007, V412, P385, DOI 10.1007/978-1-59745-467-4_25
   Neve BP, 2000, BIOCHEM PHARMACOL, V60, P1245, DOI 10.1016/S0006-2952(00)00430-5
   Nicholson AC, 2004, VASC PHARMACOL, V41, P139, DOI 10.1016/j.vph.2004.08.003
   Padilla J, 2015, DIABETES, V64, P1904, DOI 10.2337/db15-0096
   Rajsheker S, 2010, CURR OPIN PHARMACOL, V10, P191, DOI 10.1016/j.coph.2009.11.005
   Rebolledo A, 2010, CARDIOVASC DIABETOL, V9, DOI 10.1186/1475-2840-9-65
   Redondo S, 2005, DIABETES, V54, P811, DOI 10.2337/diabetes.54.3.811
   Spiroglou SG, 2010, J ATHEROSCLER THROMB, V17, P115
   Tan CH, 2014, ATHEROSCLEROSIS, V232, P199, DOI 10.1016/j.atherosclerosis.2013.11.040
   Teissier E, 2004, CIRC RES, V95, P1174, DOI 10.1161/01.RES.0000150594.95988.45
   Wang S, 2014, ISRN ENDOCRINOL, V2014
   Yau H, 2013, CURR DIABETES REP, V13, P329, DOI 10.1007/s11892-013-0378-8
NR 38
TC 27
Z9 29
U1 2
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1755-5914
EI 1755-5922
J9 CARDIOVASC THER
JI Cardiovasc. Ther.
PD JUN
PY 2018
VL 36
IS 3
AR e12322
DI 10.1111/1755-5922.12322
PG 9
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA GF4ZL
UT WOS:000431973600002
PM 29464937
OA Green Published
DA 2025-06-11
ER

PT J
AU Esteves, CL
   Kelly, V
   Bégay, V
   Man, TY
   Morton, NM
   Leutz, A
   Seckl, JR
   Chapman, KE
AF Esteves, Cristina L.
   Kelly, Val
   Begay, Valerie
   Man, Tak Y.
   Morton, Nicholas M.
   Leutz, Achim
   Seckl, Jonathan R.
   Chapman, Karen E.
TI Regulation of Adipocyte 11β-Hydroxysteroid Dehydrogenase Type 1
   (11β-HSD1) by CCAAT/Enhancer-Binding Protein (C/EBP) β Isoforms, LIP and
   LAP
SO PLOS ONE
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; TRANSCRIPTIONAL INHIBITORY PROTEIN;
   ADIPOSE-TISSUE; GENE-TRANSCRIPTION; METABOLIC SYNDROME;
   GLUCOSE-PRODUCTION; VISCERAL OBESITY; MICE; EXPRESSION; ALPHA
AB 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) catalyses intracellular regeneration of active glucocorticoids, notably in liver and adipose tissue. 11 beta-HSD1 is increased selectively in adipose tissue in human obesity, a change implicated in the pathogenesis of metabolic syndrome. With high fat (HF)-feeding, adipose tissue 11 beta-HSD1 is down-regulated in mice, plausibly to counteract metabolic disease. Transcription of 11 beta-HSD1 is directly regulated by members of the CCAAT/enhancer binding protein (C/EBP) family. Here we show that while total C/EBP beta in adipose tissue is unaltered by HF diet, the ratio of the C/EBP beta isoforms liver-enriched inhibitor protein (LIP) and liver-enriched activator protein (LAP) (C/EBP beta-LIP:LAP) is increased in subcutaneous adipose. This may cause changes in 11 beta-HSD1 expression since genetically modified C/EBP beta((+/L)) mice, with increased C/EBP beta-LIP:LAP ratio, have decreased subcutaneous adipose 11 beta-HSD1 mRNA levels, whereas C/EBP beta(Delta uORF) mice, with decreased C/EBP beta-LIP:LAP ratio, show increased subcutaneous adipose 11 beta-HSD1. C/EBP beta-LIP:LAP ratio is regulated by endoplasmic reticulum (ER) stress and mTOR signalling, both of which are altered in obesity. In 3T3-L1 adipocytes, 11 beta-HSD1 mRNA levels were down-regulated following induction of ER stress by tunicamycin but were up-regulated following inhibition of mTOR by rapamycin. These data point to a central role for C/EBP beta and its processing to LIP and LAP in transcriptional regulation of 11 beta-HSD1 in adipose tissue. Down-regulation of 11 beta-HSD1 by increased C/EBP beta-LIP:LAP in adipocytes may be part of a nutrient-sensing mechanism counteracting nutritional stress generated by HF diet.
C1 [Esteves, Cristina L.; Kelly, Val; Man, Tak Y.; Seckl, Jonathan R.; Chapman, Karen E.] Univ Edinburgh, Queens Med Res Inst, Univ BHF Ctr Cardiovasc Sci, Endocrinol Unit, Edinburgh, Midlothian, Scotland.
   [Morton, Nicholas M.] Univ Edinburgh, Queens Med Res Inst, Univ BHF Ctr Cardiovasc Sci, Mol Metab Grp, Edinburgh, Midlothian, Scotland.
   [Begay, Valerie; Leutz, Achim] Max Delbrueck Ctr Mol Med, Berlin, Germany.
C3 University of Edinburgh; University of Edinburgh; Helmholtz Association;
   Max Delbruck Center for Molecular Medicine
RP Esteves, CL (corresponding author), Univ Edinburgh, Queens Med Res Inst, Univ BHF Ctr Cardiovasc Sci, Endocrinol Unit, Edinburgh, Midlothian, Scotland.
EM Karen.Chapman@ed.ac.uk
RI Seckl, Jonathan/C-3555-2013; Esteves, Cristina/Y-5577-2019; Morton,
   NICHOLAS/ABF-3774-2020; Leutz, Achim/K-9643-2013
OI Leutz, Achim/0000-0001-8259-927X; Chapman, Karen/0000-0001-7777-6817
FU Wellcome Trust Programme Grant [WT083184]; Wellcome Trust Career
   Development Fellowship [079660/z/06/z]; Wellcome Trust [079660/Z/06/Z]
   Funding Source: Wellcome Trust
FX This work was supported by a Wellcome Trust Programme Grant (grant
   number WT083184 to JRS and KEC). NMM was funded by a Wellcome Trust
   Career Development Fellowship (grant 079660/z/06/z). The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
CR Arai N, 2007, ENDOCRINOLOGY, V148, P5268, DOI 10.1210/en.2007-0349
   Ariyama Y, 2007, OBESITY, V15, P1647, DOI 10.1038/oby.2007.197
   Arizmendi C, 1999, J BIOL CHEM, V274, P13033, DOI 10.1074/jbc.274.19.13033
   Calkhoven CF, 2000, GENE DEV, V14, P1920
   CAO ZD, 1991, GENE DEV, V5, P1538, DOI 10.1101/gad.5.9.1538
   CHRISTY RJ, 1991, P NATL ACAD SCI USA, V88, P2593, DOI 10.1073/pnas.88.6.2593
   Cucinotta M, 2008, J BIOL CHEM, V283, P29760, DOI 10.1074/jbc.M803145200
   Drake AJ, 2005, ENDOCRINOLOGY, V146, P913, DOI 10.1210/en.2004-1063
   Duong DT, 2002, J BIOL CHEM, V277, P32234, DOI 10.1074/jbc.M204873200
   Gout J, 2006, BIOCHIMIE, V88, P1115, DOI 10.1016/j.biochi.2006.05.020
   Gregor MF, 2007, J LIPID RES, V48, P1905, DOI 10.1194/jlr.R700007-JLR200
   Hermanowski-Vosatka A, 2005, J EXP MED, V202, P517, DOI 10.1084/jem.20050119
   Lee ES, 2007, FEBS LETT, V581, P4325, DOI 10.1016/j.febslet.2007.08.001
   Li Y, 2008, J BIOL CHEM, V283, P22443, DOI 10.1074/jbc.M801046200
   LIN FT, 1993, P NATL ACAD SCI USA, V90, P9606, DOI 10.1073/pnas.90.20.9606
   Lindsay RS, 2003, J CLIN ENDOCR METAB, V88, P2738, DOI 10.1210/jc.2002-030017
   Liu S, 1999, J CLIN INVEST, V103, P207, DOI 10.1172/JCI4243
   Man TY, 2011, AM J PHYSIOL-ENDOC M, V300, pE1076, DOI 10.1152/ajpendo.00531.2010
   Masaki T, 2006, BIOCHEM J, V397, P345, DOI 10.1042/BJ20051863
   Masuzaki H, 2003, J CLIN INVEST, V112, P83, DOI [10.1172/JCI200317845, 10.1172/JCI17845]
   Masuzaki H, 2001, SCIENCE, V294, P2166, DOI 10.1126/science.1066285
   Millward CA, 2007, DIABETES, V56, P161, DOI 10.2337/db06-0310
   Morton NM, 2004, DIABETES, V53, P931, DOI 10.2337/diabetes.53.4.931
   Morton NM, 2004, ENDOCRINOLOGY, V145, P2707, DOI 10.1210/en.2003-1674
   Napolitano A, 1998, J STEROID BIOCHEM, V64, P251, DOI 10.1016/S0960-0760(97)00200-8
   OSSIPOW V, 1993, P NATL ACAD SCI USA, V90, P8219, DOI 10.1073/pnas.90.17.8219
   Otto TC, 2005, CRIT REV BIOCHEM MOL, V40, P229, DOI 10.1080/10409230591008189
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Payne VA, 2007, J BIOL CHEM, V282, P21005, DOI 10.1074/jbc.M702871200
   Rahman SM, 2007, HEPATOLOGY, V45, P1108, DOI 10.1002/hep.21614
   RON D, 1992, GENE DEV, V6, P439, DOI 10.1101/gad.6.3.439
   Rosenstock J, 2010, DIABETES CARE, V33, P1516, DOI 10.2337/dc09-2315
   Sai S, 2008, MOL ENDOCRINOL, V22, P2049, DOI 10.1210/me.2007-0489
   Seckl JR, 2004, RECENT PROG HORM RES, V59, P359, DOI 10.1210/rp.59.1.359
   Siu F, 2001, J BIOL CHEM, V276, P48100, DOI 10.1074/jbc.M109533200
   Smink JJ, 2009, EMBO J, V28, P1769, DOI 10.1038/emboj.2009.127
   Tanaka T, 1997, EMBO J, V16, P7432, DOI 10.1093/emboj/16.24.7432
   Wake DJ, 2003, J CLIN ENDOCR METAB, V88, P3983, DOI 10.1210/jc.2003-030286
   WANG ND, 1995, SCIENCE, V269, P1108, DOI 10.1126/science.7652557
   Welm AL, 1999, MOL CELL BIOL, V19, P1695
   Wethmar K, GENES DEV, V24, P15
   Williams LJS, 2000, J BIOL CHEM, V275, P30232, DOI 10.1074/jbc.M001286200
   Yang Z, 2007, J ENDOCRINOL, V195, P241, DOI 10.1677/JOE-07-0303
   Yang Z, 2009, ENDOCRINE, V36, P404, DOI 10.1007/s12020-009-9245-4
NR 44
TC 20
Z9 22
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 25
PY 2012
VL 7
IS 5
AR e37953
DI 10.1371/journal.pone.0037953
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 959UY
UT WOS:000305342300145
PM 22662254
OA Green Published, Green Submitted, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Brunner, EJ
   Hemingway, H
   Walker, BR
   Page, M
   Clarke, P
   Juneja, M
   Shipley, MJ
   Kumari, M
   Andrew, R
   Seckl, JR
   Papadopoulos, A
   Checkley, S
   Rumley, A
   Lowe, GDO
   Stansfeld, SA
   Marmot, MG
AF Brunner, EJ
   Hemingway, H
   Walker, BR
   Page, M
   Clarke, P
   Juneja, M
   Shipley, MJ
   Kumari, M
   Andrew, R
   Seckl, JR
   Papadopoulos, A
   Checkley, S
   Rumley, A
   Lowe, GDO
   Stansfeld, SA
   Marmot, MG
TI Adrenocortical, autonomic, and inflammatory causes of the metabolic
   syndrome - Nested case-control study
SO CIRCULATION
LA English
DT Article
DE norepinephrine; coronary disease; stress; metabolism; heart rate
ID CORONARY-HEART-DISEASE; INSULIN-RESISTANCE; ATHEROSCLEROSIS RISK;
   RATE-VARIABILITY; STRESS; CORTISOL; OBESITY; DETERMINANTS; FIBRINOLYSIS;
   INEQUALITIES
AB Background-The causes of metabolic syndrome (MS), which may be a precursor of coronary disease, are uncertain. We hypothesize that disturbances in neuroendocrine and cardiac autonomic activity (CAA) contribute to development of MS. We examine reversibility and the power of psychosocial and behavioral factors to explain the neuroendocrine adaptations that accompany MS.
   Methods and Results-This was a double-blind case-control study of working men aged 45 to 63 years drawn from the Whitehall II cohort. MS cases (n = 30) were compared with healthy controls (n = 153). Cortisol secretion, sensitivity, and 24-hour cortisol metabolite and catecholamine output were measured over 2 days. CAA was obtained from power spectral analysis of heart rate variability (HRV) recordings. Twenty-four-hour cortisol metabolite and normetanephrine (3-methoxynorepinephrine) outputs were higher among cases than controls (+0.49, +0.45 SD, respectively). HRV and total power were lower among cases (both -0.72 SD). Serum interleukin-6, plasma C-reactive protein, and viscosity were higher among cases (+0.89, +0.51, and +0.72 SD). Lower HRV was associated with higher normetanephrine output (r=-0.19; P=0.03). Among former cases (MS 5 years previously, n=23), cortisol output, heart rate, and interleukin-6 were at the level of controls. Psychosocial factors accounted for 37% of the link between MS and normetanephrine output, and 7% to 19% for CAA. Health-related behaviors accounted for 5% to 18% of neuroendocrine differences.
   Conclusions-Neuroendocrine stress axes are activated in MS. There is relative cardiac sympathetic predominance. The neuroendocrine changes may be reversible. This case-control study provides the first evidence that chronic stress may be a cause of MS. Confirmatory prospective studies are required.
C1 UCL, Dept Epidemiol & Publ Hlth, Int Ctr Hlth & Society, London, England.
   Univ Edinburgh, Western Gen Hosp, Endocrinol Unit, Edinburgh EH8 9YL, Midlothian, Scotland.
   Bethlem Royal & Maudsley Hosp, Inst Psychiat, London, England.
   Univ Glasgow, Royal Infirm, Dept Med, Glasgow G12 8QQ, Lanark, Scotland.
   Queen Mary Univ London, Dept Community Psychiat, London, England.
C3 University of London; University College London; University of
   Edinburgh; South London & Maudsley NHS Trust; Bethlem Royal Hospital;
   University of London; King's College London; Royal Infirmary of
   Edinburgh; University of Glasgow; University of London; Queen Mary
   University London
RP UCL, Dept Epidemiol & Publ Hlth, Int Ctr Hlth & Society, 1-19 Torrington Pl, London, England.
EM e.brunner@ucl.ac.uk
RI Andrew, Ruth/C-2727-2008; Seckl, Jonathan/C-3555-2013; Brunner,
   Eric/H-2114-2011; Marmot, Michael/Y-3920-2019; Hemingway,
   Harry/C-1219-2009
OI Marmot, Michael/0000-0002-2431-6419; Andrew, Ruth/0000-0002-6916-2994;
   Brunner, Eric/0000-0002-0595-4474; Hemingway, Harry/0000-0003-2279-0624;
   Kumari, Meena/0000-0001-9716-1035
FU AHRQ HHS [HS06516] Funding Source: Medline; Medical Research Council
   [G8802774, G0100222, G19/35] Funding Source: Medline; NHLBI NIH HHS
   [HL36310] Funding Source: Medline; NIA NIH HHS [AG13196] Funding Source:
   Medline
CR Andrew R, 1998, J CLIN ENDOCR METAB, V83, P1806, DOI 10.1210/jc.83.5.1806
   Bearn J, 2001, ADDICT BIOL, V6, P157, DOI 10.1080/13556210020040235
   BERNE C, 1992, DIABETOLOGIA, V35, P873, DOI 10.1007/BF00399935
   Björntorp P, 1999, DIABETIC MED, V16, P373, DOI 10.1046/j.1464-5491.1999.00067.x
   Brunner E, 1996, LANCET, V347, P1008, DOI 10.1016/S0140-6736(96)90147-6
   Brunner E, 1997, BMJ-BRIT MED J, V314, P1472, DOI 10.1136/bmj.314.7092.1472
   Brunner EJ, 1997, DIABETOLOGIA, V40, P1341, DOI 10.1007/s001250050830
   Camm AJ, 1996, CIRCULATION, V93, P1043
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Curtin F, 1996, J AFFECT DISORDERS, V38, P173, DOI 10.1016/0165-0327(96)00011-0
   Danesh J, 1998, JAMA-J AM MED ASSOC, V279, P1477, DOI 10.1001/jama.279.18.1477
   Duncan BB, 2000, OBES RES, V8, P279, DOI 10.1038/oby.2000.33
   Hemingway H, 1999, BMJ-BRIT MED J, V318, P1460, DOI 10.1136/bmj.318.7196.1460
   Hemingway H, 2001, EUR HEART J, V22, P1082, DOI 10.1053/euhj.2000.2534
   KAWACHI I, 1995, AM J CARDIOL, V75, P882, DOI 10.1016/S0002-9149(99)80680-8
   KUPER H, IN PRESS J EPIDEMIOL
   Liao DP, 1998, DIABETES CARE, V21, P2116, DOI 10.2337/diacare.21.12.2116
   Liao DP, 1997, AM J EPIDEMIOL, V145, P696, DOI 10.1093/aje/145.8.696
   Marmot M, 2001, NEW ENGL J MED, V345, P134, DOI 10.1056/NEJM200107123450210
   MARMOT MG, 1991, LANCET, V337, P1387, DOI 10.1016/0140-6736(91)93068-K
   Marmot MG, 1997, LANCET, V350, P235, DOI 10.1016/S0140-6736(97)04244-X
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   Phillips DIW, 1998, J CLIN ENDOCR METAB, V83, P757, DOI 10.1210/jc.83.3.757
   Reaven GM, 1996, NEW ENGL J MED, V334, P374, DOI 10.1056/NEJM199602083340607
   Sakkinen PA, 2000, AM J EPIDEMIOL, V152, P897, DOI 10.1093/aje/152.10.897
   Schafer JL, 1997, ANAL INCOMPLETE MULT
   Schmidt MI, 1999, LANCET, V353, P1649, DOI 10.1016/S0140-6736(99)01046-6
   von Känel R, 2001, PSYCHOSOM MED, V63, P531, DOI 10.1097/00006842-200107000-00003
   Walker BR, 1998, HYPERTENSION, V31, P891, DOI 10.1161/01.HYP.31.4.891
   Yarnell JWG, 2000, ARTERIOSCL THROM VAS, V20, P271, DOI 10.1161/01.ATV.20.1.271
   Yudkin JS, 2000, ATHEROSCLEROSIS, V148, P209, DOI 10.1016/S0021-9150(99)00463-3
NR 31
TC 409
Z9 460
U1 0
U2 27
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD NOV 19
PY 2002
VL 106
IS 21
BP 2659
EP 2665
DI 10.1161/01.CIR.0000038364.26310.BD
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 618LX
UT WOS:000179420500009
PM 12438290
OA Bronze
DA 2025-06-11
ER

PT J
AU Huang, YJ
   Tsai, SY
   Chung, KH
   Chen, PH
   Huang, SH
   Kuo, CJ
AF Huang, Yu-Jui
   Tsai, Shang-Ying
   Chung, Kuo-Hsuan
   Chen, Pao-Huan
   Huang, Shou-Hung
   Kuo, Chian-Jue
TI State-dependent alterations of lipid profiles in patients with bipolar
   disorder
SO INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE
LA English
DT Article
DE bipolar disorder; mania; depression; cholesterol; triglyceride
ID METABOLIC SYNDROME; MEMBRANE CHOLESTEROL; SERUM-LIPIDS; RECEPTOR;
   INSULIN; LEPTIN; SCHIZOPHRENIA; INFLAMMATION; DEPRESSION; GLUCOSE
AB Objective Serum lipid levels may be associated with the affective severity of bipolar disorder, but data on lipid profiles in Asian patients with bipolar disorder and the lipid alterations in different states of opposite polarities are scant. We investigated the lipid profiles of patients in the acute affective, partial, and full remission state in bipolar mania and depression.
   Methods The physically healthy patients aged between 18 and 45 years with bipolar I disorder, as well as age-matched healthy normal controls were enrolled. We compared the fasting blood levels of glucose, cholesterol, triglyceride, low-density lipoprotein, and high-density lipoprotein of manic or depressed patients in the acute phase and subsequent partial and full remission with those of their normal controls.
   Results A total of 32 bipolar manic patients (12 women and 20 men), 32 bipolar depressed participants (18 women and 14 men), and 64 healthy control participants took part in this study. The mean cholesterol level in acute mania was significantly lower than that in acute depression (p<0.025). The lowest rate of dyslipidemia (hypertriglyceridemia or low high-density lipoprotein cholesterol) was observed in acute bipolar mania.
   Conclusion Circulating lipid profiles may be easily affected by affective states. The acute manic state may be accompanied by state-dependent lower cholesterol and triglyceride levels relative to that in other mood states.
C1 [Huang, Yu-Jui; Tsai, Shang-Ying; Chung, Kuo-Hsuan; Chen, Pao-Huan; Huang, Shou-Hung] Taipei Med Univ Hosp, Dept Psychiat, Taipei, Taiwan.
   [Huang, Yu-Jui; Tsai, Shang-Ying; Chung, Kuo-Hsuan; Chen, Pao-Huan; Huang, Shou-Hung] Taipei Med Univ Hosp, Psychiat Res Ctr, Taipei, Taiwan.
   [Tsai, Shang-Ying; Chung, Kuo-Hsuan; Chen, Pao-Huan; Huang, Shou-Hung; Kuo, Chian-Jue] Taipei Med Univ, Coll Med, Sch Med, Dept Psychiat, Taipei, Taiwan.
   [Kuo, Chian-Jue] Taipei City Hosp, Songde Branch, Taipei City Psychiat Ctr, Taipei, Taiwan.
C3 Taipei Medical University; Taipei Medical University Hospital; Taipei
   Medical University; Taipei Medical University Hospital; Taipei Medical
   University; Taipei City Hospital
RP Tsai, SY (corresponding author), 252 Wu Hsing St, Taipei 110, Taiwan.
EM tmcpsyts@tmu.edu.tw
RI Chen, Pao-Huan/ABG-5963-2020
OI Chung, Kuo-Hsuan/0000-0002-5570-3972; TSAI,
   SHANGYING/0000-0001-5662-0055
CR Abulrob A, 2005, J NEUROCHEM, V92, P1477, DOI 10.1111/j.1471-4159.2005.03001.x
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Atmaca M, 2002, NEUROPSYCHOBIOLOGY, V46, P176, DOI 10.1159/000067809
   Butchbach MER, 2004, J BIOL CHEM, V279, P34388, DOI 10.1074/jbc.M403938200
   Cassidy F, 2002, EUR ARCH PSY CLIN N, V252, P110, DOI 10.1007/s00406-002-0367-4
   CHENG TA, 1986, PSYCHOL MED, V16, P415, DOI 10.1017/S0033291700009247
   Chung KH, 2007, PSYCHIAT CLIN NEUROS, V61, P428, DOI 10.1111/j.1440-1819.2007.01689.x
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   Fiedorowicz JG, 2010, PSYCHIAT RES, V175, P78, DOI 10.1016/j.psychres.2009.01.001
   Frank C, 2004, FEBS LETT, V566, P25, DOI 10.1016/j.febslet.2004.03.113
   Ghaemi SN, 2000, BIPOLAR DISORD, V2, P60, DOI 10.1034/j.1399-5618.2000.020109.x
   Goldsmith DR, 2016, MOL PSYCHIATR, V21, P1696, DOI 10.1038/mp.2016.3
   Grimble RF, 2002, CURR OPIN CLIN NUTR, V5, P551, DOI 10.1097/00075197-200209000-00015
   HAMILTON M, 1967, Br J Soc Clin Psychol, V6, P278
   Hwang LC, 2007, EUR J EPIDEMIOL, V22, P899, DOI 10.1007/s10654-007-9183-5
   Kilbourne AM, 2004, BIPOLAR DISORD, V6, P368, DOI 10.1111/j.1399-5618.2004.00138.x
   McElroy SL, 2002, J CLIN PSYCHIAT, V63, P207, DOI 10.4088/JCP.v63n0306
   Muneer A, 2016, PSYCHIAT INVEST, V13, P18, DOI 10.4306/pi.2016.13.1.18
   Pae CU, 2004, J AFFECT DISORDERS, V83, P79, DOI 10.1016/j.jad.2004.04.010
   Rosso G, 2015, J AFFECT DISORDERS, V184, P293, DOI 10.1016/j.jad.2015.06.006
   Sagud M, 2007, J AFFECT DISORDERS, V97, P247, DOI 10.1016/j.jad.2006.05.030
   Sooksawate T, 2001, BRIT J PHARMACOL, V134, P1303, DOI 10.1038/sj.bjp.0704360
   Sooksawate T, 2001, NEUROPHARMACOLOGY, V40, P178, DOI 10.1016/S0028-3908(00)00159-3
   Tsai SY, 2014, BIPOLAR DISORD, V16, P800, DOI 10.1111/bdi.12240
   Tsai SY, 2012, J AFFECT DISORDERS, V136, P110, DOI 10.1016/j.jad.2011.08.022
   Tsai SY, 1999, BIOL PSYCHIAT, V45, P989, DOI 10.1016/S0006-3223(98)00159-0
   Tsai SYM, 2001, J AFFECT DISORDERS, V64, P185, DOI 10.1016/S0165-0327(00)00252-4
   van Winkel R, 2008, BIPOLAR DISORD, V10, P342, DOI 10.1111/j.1399-5618.2007.00520.x
   Wysokinski A, 2015, DIABETES METAB SYND, V9, P168, DOI 10.1016/j.dsx.2015.04.004
   YOUNG RC, 1978, BRIT J PSYCHIAT, V133, P429, DOI 10.1192/bjp.133.5.429
   Yumru M, 2007, J AFFECT DISORDERS, V98, P247, DOI 10.1016/j.jad.2006.08.009
NR 31
TC 24
Z9 26
U1 0
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0091-2174
EI 1541-3527
J9 INT J PSYCHIAT MED
JI Int. J. Psychiatr. Med.
PD JUL
PY 2018
VL 53
IS 4
BP 273
EP 281
DI 10.1177/0091217417749786
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GH6FH
UT WOS:000433538600003
PM 29280686
DA 2025-06-11
ER

PT J
AU Sletten, AC
   Davidson, JW
   Yagabasan, B
   Moores, S
   Schwaiger-Haber, M
   Fujiwara, H
   Gale, S
   Jiang, XT
   Sidhu, R
   Gelman, S
   Zhao, S
   Patti, G
   Ory, DS
   Schaffer, JE
AF Sletten, Arthur C.
   Davidson, Jessica W.
   Yagabasan, Busra
   Moores, Samantha
   Schwaiger-Haber, Michaela
   Fujiwara, Hideji
   Gale, Sarah
   Jiang, Xuntian
   Sidhu, Rohini
   Gelman, Susan
   Zhao, Shuang
   Patti, Gary
   Ory, Daniel S.
   Schaffer, Jean E.
TI Loss of SNORA73 reprograms cellular metabolism and protects against
   steatohepatitis
SO NATURE COMMUNICATIONS
LA English
DT Article
ID SMALL NUCLEOLAR RNAS; PRE-RIBOSOMAL-RNA; HEPATIC STEATOSIS;
   MITOCHONDRIAL DYSFUNCTION; OXIDATIVE-STRESS; ACTIVATION; GLUCOSE; MODEL;
   LIVER; MICE
AB Lipid induced stress contributes to metabolic diseases. Here the authors identify small nucleolar RNA 73 (SNORA73) in a screen for genes that protect against lipotoxicity and show that deficiency of SNORA73 reprograms oxidative metabolism and protects against steatohepatitis in mice.
   Dyslipidemia and resulting lipotoxicity are pathologic signatures of metabolic syndrome and type 2 diabetes. Excess lipid causes cell dysfunction and induces cell death through pleiotropic mechanisms that link to oxidative stress. However, pathways that regulate the response to metabolic stress are not well understood. Herein, we show that disruption of the box H/ACA SNORA73 small nucleolar RNAs encoded within the small nucleolar RNA hosting gene 3 (Snhg3) causes resistance to lipid-induced cell death and general oxidative stress in cultured cells. This protection from metabolic stress is associated with broad reprogramming of oxidative metabolism that is dependent on the mammalian target of rapamycin signaling axis. Furthermore, we show that knockdown of SNORA73 in vivo protects against hepatic steatosis and lipid-induced oxidative stress and inflammation. Our findings demonstrate a role for SNORA73 in the regulation of metabolism and lipotoxicity.
C1 [Sletten, Arthur C.; Fujiwara, Hideji; Gale, Sarah; Jiang, Xuntian; Sidhu, Rohini; Zhao, Shuang; Ory, Daniel S.] Washington Univ, Dept Med, St Louis, MO USA.
   [Davidson, Jessica W.; Yagabasan, Busra; Moores, Samantha; Schaffer, Jean E.] Harvard Med Sch, Joslin Diabet Ctr, Boston, MA 02115 USA.
   [Schwaiger-Haber, Michaela; Gelman, Susan; Patti, Gary] Washington Univ, Dept Chem, St Louis, MO USA.
C3 Washington University (WUSTL); Harvard University; Harvard University
   Medical Affiliates; Joslin Diabetes Center, Inc.; Harvard Medical
   School; Washington University (WUSTL)
RP Schaffer, JE (corresponding author), Harvard Med Sch, Joslin Diabet Ctr, Boston, MA 02115 USA.
EM jean.schaffer@joslin.harvard.edu
RI Ory, Daniel/IAP-9009-2023; Sidhu, Rohini/G-3547-2012
OI Yagabasan, Busra/0000-0003-4351-6165; Schwaiger-Haber,
   Michaela/0000-0002-2715-753X
FU NIH [R01 DK108357, R01 DK064989, F30 DK120141, T32 HL007275, T32
   GM07200]; Washington University Diabetes Research Center [P30 DK020579];
   Joslin Diabetes Research Center [P30 DK036836]; National Institute of
   Diabetes and Digestive and Kidney Diseases [F30DK120141, R01DK064989]
   Funding Source: NIH RePORTER
FX This work was supported by the following grants from the NIH: R01
   DK108357 and R01 DK064989 (J.E.S.); F30 DK120141, T32 HL007275, and T32
   GM07200 (A.C.S.); the Washington University Diabetes Research Center P30
   DK020579 and the Joslin Diabetes Research Center P30 DK036836 (Flow
   Cytometry and Molecular Phenotyping & Genotyping Cores). We thank the
   Joslin Bioinformatics and Biostatistics Core for assistance in analysis
   of RNA sequence data and Dr. James Remington for providing a roGFP
   plasmid.
CR Ahn WS, 2013, METAB ENG, V15, P34, DOI 10.1016/j.ymben.2012.10.001
   Antinozzi PA, 1998, J BIOL CHEM, V273, P16146, DOI 10.1074/jbc.273.26.16146
   Atzorn V, 2004, MOL CELL BIOL, V24, P1769, DOI 10.1128/MCB.24.4.1769-1778.2004
   Betz C, 2013, P NATL ACAD SCI USA, V110, P12526, DOI 10.1073/pnas.1302455110
   Borradaile NM, 2006, J LIPID RES, V47, P2726, DOI 10.1194/jlr.M600299-JLR200
   Borradaile NM, 2006, MOL BIOL CELL, V17, P770, DOI 10.1091/mbc.E05-08-0742
   Bray NL, 2016, NAT BIOTECHNOL, V34, P525, DOI 10.1038/nbt.3519
   Brookheart RT, 2009, J BIOL CHEM, V284, P7446, DOI 10.1074/jbc.M806209200
   Browning JD, 2004, J CLIN INVEST, V114, P147, DOI 10.1172/JCI200422422
   Cantó C, 2015, CELL METAB, V22, P31, DOI 10.1016/j.cmet.2015.05.023
   Chaurasia B, 2015, TRENDS ENDOCRIN MET, V26, P538, DOI 10.1016/j.tem.2015.07.006
   Chen J, 2009, NUCLEIC ACIDS RES, V37, pW305, DOI 10.1093/nar/gkp427
   Chen SF, 2018, BIOINFORMATICS, V34, P884, DOI 10.1093/bioinformatics/bty560
   Circu ML, 2010, FREE RADICAL BIO MED, V48, P749, DOI 10.1016/j.freeradbiomed.2009.12.022
   Cunningham JT, 2007, NATURE, V450, P736, DOI 10.1038/nature06322
   Dooley CT, 2004, J BIOL CHEM, V279, P22284, DOI 10.1074/jbc.M312847200
   Enright CA, 1996, RNA, V2, P1094
   Ertunc ME, 2016, J LIPID RES, V57, P2099, DOI 10.1194/jlr.R066514
   Fan WW, 2008, SCIENCE, V319, P958, DOI 10.1126/science.1147786
   Gerashchenko MV, 2021, METHODS MOL BIOL, V2252, P189, DOI 10.1007/978-1-0716-1150-0_8
   Gu XF, 2020, CANCER MED-US, V9, P5719, DOI 10.1002/cam4.3275
   Guo Y, 2008, NATURE, V453, P657, DOI 10.1038/nature06928
   Heiden MGV, 2009, SCIENCE, V324, P1029, DOI 10.1126/science.1160809
   Henras AK, 2015, WIRES RNA, V6, P225, DOI 10.1002/wrna.1269
   Hesselink MKC, 2016, NAT REV ENDOCRINOL, V12, P633, DOI 10.1038/nrendo.2016.104
   Hue L, 2009, AM J PHYSIOL-ENDOC M, V297, pE578, DOI 10.1152/ajpendo.00093.2009
   Iadevaia V, 2012, NUCLEIC ACIDS RES, V40, P2527, DOI 10.1093/nar/gkr1040
   Inoguchi T, 2000, DIABETES, V49, P1939, DOI 10.2337/diabetes.49.11.1939
   Ito M, 2007, HEPATOL RES, V37, P50, DOI 10.1111/j.1872-034X.2007.00008.x
   Jinn S, 2015, CELL METAB, V21, P855, DOI 10.1016/j.cmet.2015.04.010
   Koves TR, 2008, CELL METAB, V7, P45, DOI 10.1016/j.cmet.2007.10.013
   Langmead B, 2012, NAT METHODS, V9, P357, DOI [10.1038/NMETH.1923, 10.1038/nmeth.1923]
   Law CW, 2014, GENOME BIOL, V15, DOI 10.1186/gb-2014-15-2-r29
   Lee JY, 2016, J CLIN INVEST, V126, P4616, DOI 10.1172/JCI88069
   LEE Y, 1994, P NATL ACAD SCI USA, V91, P10878, DOI 10.1073/pnas.91.23.10878
   Lempiäinen H, 2009, MOL CELL, V33, P704, DOI 10.1016/j.molcel.2009.01.034
   Li H, 2009, BIOINFORMATICS, V25, P2078, DOI 10.1093/bioinformatics/btp352
   Liang XH, 2011, NUCLEIC ACIDS RES, V39, DOI 10.1093/nar/gkq1121
   Listenberger LL, 2001, J BIOL CHEM, V276, P14890, DOI 10.1074/jbc.M010286200
   Listenberger LL, 2003, P NATL ACAD SCI USA, V100, P3077, DOI 10.1073/pnas.0630588100
   Liu R, 2014, NUCLEIC ACIDS RES, V42, P5083, DOI 10.1093/nar/gku130
   Lowell BB, 2005, SCIENCE, V307, P384, DOI 10.1126/science.1104343
   Machado MV, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0127991
   MacLean B, 2010, BIOINFORMATICS, V26, P966, DOI 10.1093/bioinformatics/btq054
   Mailloux RJ, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/7857251
   Matsusue K, 2003, J CLIN INVEST, V111, P737, DOI 10.1172/JCI200317223
   Michel CI, 2011, CELL METAB, V14, P33, DOI 10.1016/j.cmet.2011.04.009
   Moore T, 2013, J CHROMATOGR B, V929, P51, DOI 10.1016/j.jchromb.2013.04.004
   Morita M, 2013, CELL METAB, V18, P698, DOI 10.1016/j.cmet.2013.10.001
   Murphy MP, 2013, CELL METAB, V18, P145, DOI 10.1016/j.cmet.2013.07.006
   O'Leary NA, 2016, NUCLEIC ACIDS RES, V44, pD733, DOI 10.1093/nar/gkv1189
   Ostrander DB, 2001, J BIOL CHEM, V276, P25262, DOI 10.1074/jbc.M103689200
   Ott M, 2007, APOPTOSIS, V12, P913, DOI 10.1007/s10495-007-0756-2
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Piccolis M, 2019, MOL CELL, V74, P32, DOI 10.1016/j.molcel.2019.01.036
   Porter FD, 2010, SCI TRANSL MED, V2, DOI 10.1126/scitranslmed.3001417
   Quiros Pedro M, 2017, Curr Protoc Mouse Biol, V7, P47, DOI 10.1002/cpmo.21
   Ramanathan A, 2009, P NATL ACAD SCI USA, V106, P22229, DOI 10.1073/pnas.0912074106
   Rinella ME, 2008, J LIPID RES, V49, P1068, DOI 10.1194/jlr.M800042-JLR200
   Ritchie ME, 2015, NUCLEIC ACIDS RES, V43, DOI 10.1093/nar/gkv007
   Robinson MD, 2010, GENOME BIOL, V11, DOI 10.1186/gb-2010-11-3-r25
   Robinson MD, 2015, F1000RES, V4, P1521, DOI DOI 10.12688/F1000RESEARCH.7563.1
   Rosario FJ, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-36265-8
   Ruggles KV, 2014, J BIOL CHEM, V289, P4417, DOI 10.1074/jbc.M113.515197
   Sadidi M, 2009, BIOCHIMIE, V91, P577, DOI 10.1016/j.biochi.2009.01.010
   Saxton RA, 2017, CELL, V168, P960, DOI [10.1016/j.cell.2017.02.004, 10.1016/j.cell.2017.03.035]
   Schilling JD, 2013, J IMMUNOL, V190, P1285, DOI 10.4049/jimmunol.1202208
   Schuster S, 2018, NAT REV GASTRO HEPAT, V15, P349, DOI 10.1038/s41575-018-0009-6
   Scruggs BS, 2012, MOL CELL BIOL, V32, P4092, DOI 10.1128/MCB.00022-12
   Shabgah AG, 2021, NUTR METAB, V18, DOI 10.1186/s12986-021-00552-5
   Su XY, 2017, ANAL CHEM, V89, P5941, DOI 10.1021/acs.analchem.7b00396
   Thorpe GW, 2004, P NATL ACAD SCI USA, V101, P6564, DOI 10.1073/pnas.0305888101
   Tsang CK, 2010, CELL CYCLE, V9, P953, DOI 10.4161/cc.9.5.10876
   Volkmann X, 2007, HEPATOLOGY, V46, P1498, DOI 10.1002/hep.21846
   Wang MS, 2011, NUCLEIC ACIDS RES, V39, P1811, DOI 10.1093/nar/gkq1050
   Wang XB, 2016, CELL METAB, V24, P848, DOI 10.1016/j.cmet.2016.09.016
   Weber MJ, 2006, PLOS GENET, V2, P1984, DOI 10.1371/journal.pgen.0020205
   Winterbourn CC, 2008, FREE RADICAL BIO MED, V45, P549, DOI 10.1016/j.freeradbiomed.2008.05.004
   Wu J, 2019, ONCOTARGETS THER, V12, P6623, DOI 10.2147/OTT.S196630
   Yamaguchi K, 2007, HEPATOLOGY, V45, P1366, DOI 10.1002/hep.21655
   Yu YT, 2014, RNA BIOL, V11, P1483, DOI 10.4161/15476286.2014.972855
   Zhang PF, 2019, J CELL PHYSIOL, V234, P2788, DOI 10.1002/jcp.27095
   Zhao Q, 2019, TOHOKU J EXP MED, V249, P43, DOI 10.1620/tjem.249.43
   Zhu XG, 2019, MOL CELL, V74, P45, DOI 10.1016/j.molcel.2019.01.037
   Zinzalla V, 2011, CELL, V144, P757, DOI 10.1016/j.cell.2011.02.014
NR 85
TC 23
Z9 24
U1 3
U2 13
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
EI 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD SEP 1
PY 2021
VL 12
IS 1
AR 5214
DI 10.1038/s41467-021-25457-y
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA UL1FX
UT WOS:000692406100020
PM 34471131
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Radajewska, A
   Szyller, J
   Niewiadomska, J
   Noszczyk-Nowak, A
   Bil-Lula, I
AF Radajewska, Anna
   Szyller, Jakub
   Niewiadomska, Joanna
   Noszczyk-Nowak, Agnieszka
   Bil-Lula, Iwona
TI Punica granatum L. Polyphenolic Extract as an Antioxidant to
   Prevent Kidney Injury in Metabolic Syndrome Rats
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID DIABETIC-NEPHROPATHY; LIPID-PEROXIDATION; OXIDATIVE STRESS; MOLECULE-1
   KIM-1; BLOOD-VISCOSITY; POMEGRANATE; OBESITY; DISEASE; ASSOCIATION;
   GLUTATHIONE
AB Introduction. Obesity and metabolic syndrome (MetS) constitute a rapidly increasing health problem and contribute to the development of multiple comorbidities like acute and chronic kidney disease. Insulin resistance, inappropriate lipolysis, and excess of free fatty acids (FFAs) are associated with glomerulus hyperfiltration and atherosclerosis. The important component of MetS, oxidative stress, is also involved in the destabilization of kidney function and the progression of kidney injury. Natural polyphenols have the ability to reduce the harmful effect of reactive oxygen and nitrogen species (ROS/RNS). Extract derived from Punica granatum L. is rich in punicalagin that demonstrates positive effects in MetS and its associated diseases. The aim of the study was to investigate the effect of bioactive substances of pomegranate peel to kidney damage associated with the MetS. Methods. In this study, we compared biomarkers of oxidative stress in kidney tissue of adult male Zucker Diabetic Fatty (ZDF) rats with MetS and healthy controls that were treated with Punica granatum L. extract at a dose of 100 or 200 mg/kg. Additionally, we evaluated the effect of polyphenolic extract on kidney injury markers and remodeling. The concentration of ROS/RNS, oxLDL, glutathione (GSH), kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), metalloproteinase 2 and 9 (MMP-2, MMP-9), and the activity of superoxide dismutase (SOD) and catalase (CAT) were measured. Results. The data showed significant differences in oxidative stress markers between treated and untreated MetS rats. ROS/RNS levels, oxLDL concentration, and SOD activity were lower, whereas CAT activity was higher in rats with MetS receiving polyphenolic extract. After administration of the extract, markers for kidney injury (NGAL, KIM-1) decreased. Conclusion. Our study confirmed the usefulness of pomegranate polyphenols in the treatment of MetS and the prevention of kidney damage. However, further, more detailed research is required to establish the mechanism of polyphenol protection.
C1 [Radajewska, Anna; Szyller, Jakub; Bil-Lula, Iwona] Wroclaw Med Univ, Fac Pharm, Dept Med Lab Diag, Div Clin Chem & Lab Hematol, Borowska 211A, PL-50556 Wroclaw, Poland.
   [Niewiadomska, Joanna; Noszczyk-Nowak, Agnieszka] Univ Environm & Life Sci, Dept Internal Med, Grunwaldzki Sq 47, PL-50366 Wroclaw, Poland.
   [Niewiadomska, Joanna; Noszczyk-Nowak, Agnieszka] Univ Environm & Life Sci, Fac Vet Med, Clin Dis Horses Dogs & Cats, Grunwaldzki Sq 47, PL-50366 Wroclaw, Poland.
C3 Wroclaw Medical University; Wroclaw University of Environmental & Life
   Sciences; Wroclaw University of Environmental & Life Sciences
RP Bil-Lula, I (corresponding author), Wroclaw Med Univ, Fac Pharm, Dept Med Lab Diag, Div Clin Chem & Lab Hematol, Borowska 211A, PL-50556 Wroclaw, Poland.
EM anna.radajewska@student.umw.edu.pl; jakub.szyller@umw.edu.pl;
   joanna.niewiadomska@upwr.edu.pl; agnieszka.noszczyk-nowak@upwr.edu.pl;
   iwona.bil-lula@umw.edu.pl
RI Noszczyk-Nowak, Agnieszka/AAF-8041-2020; Szyller, Jakub/AAZ-1156-2021;
   Bil-Lula, Iwona/ABA-2361-2021; Noszczyk-Nowak, Agnieszka/G-9438-2017
OI Szyller, Jakub/0000-0002-1320-4112; Noszczyk-Nowak,
   Agnieszka/0000-0001-7899-3936; Niewiadomska, Joanna/0000-0001-7102-0779;
   Bil-Lula, Iwona/0000-0002-2769-0166; Radajewska,
   Anna/0000-0003-1639-3155
FU Wroclaw Medical University [SUBK.D010.22.010]
FX AcknowledgmentsThis study was supported by the Wroclaw Medical
   University Grant no. SUBK.D010.22.010.
CR Al-Kuraishy H.M., 2019, Asian Journal of Pharmaceutical and Clinical Research, V12, P1, DOI DOI 10.22159/AJPCR.2019.V12I3.30894
   Al-kuraishy HM, 2023, CLIN EXP MED, V23, P679, DOI 10.1007/s10238-022-00836-x
   Al-kuraishy HM, 2019, J CONTEMP MED SCI, V5, P35
   Aladaileh SH, 2021, LIFE SCI, V286, DOI 10.1016/j.lfs.2021.120071
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Ali BH, 2016, CELL PHYSIOL BIOCHEM, V38, P248, DOI 10.1159/000438626
   Alorabi M, 2022, BIOMED PHARMACOTHER, V152, DOI 10.1016/j.biopha.2022.113225
   An X, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051516
   Atale N, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/8839479
   Bakhtiari A, 2017, BIOMED REP, V7, P331, DOI 10.3892/br.2017.964
   Banaszkiewicz M, 2022, CARDIOVASC THER, V2022, DOI 10.1155/2022/9729018
   Bi H, 2014, INT J CLIN EXP MED, V7, P4448
   Calabriso N, 2016, MOLECULES, V21, DOI 10.3390/molecules21091147
   Cao HM, 2014, J ENDOCRINOL, V220, pT47, DOI 10.1530/JOE-13-0339
   Cheng ZY, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18040776
   Crascì L, 2018, CRIT REV FOOD SCI, V58, P893, DOI 10.1080/10408398.2016.1229657
   DeVallance E, 2019, ANTIOXID REDOX SIGN, V31, P687, DOI 10.1089/ars.2018.7674
   Eo H, 2017, J AGR FOOD CHEM, V65, P3811, DOI 10.1021/acs.jafc.7b00357
   Fouad AA, 2016, TOXICOL MECH METHOD, V26, P538, DOI 10.1080/15376516.2016.1211207
   Fuhrman B, 2005, J NUTR BIOCHEM, V16, P570, DOI 10.1016/j.jnutbio.2005.02.009
   Funamoto M, 2016, ANN THORAC SURG, V101, P1507, DOI 10.1016/j.athoracsur.2015.09.080
   Garud MS, 2018, CHEM-BIOL INTERACT, V282, P69, DOI 10.1016/j.cbi.2018.01.010
   Ghasemi H, 2019, IRAN J BASIC MED SCI, V22, P376, DOI 10.22038/ijbms.2019.31922.7674
   Gnasso A, 2018, CLIN HEMORHEOL MICRO, V68, P45, DOI 10.3233/CH-170288
   Go AS, 2004, NEW ENGL J MED, V351, P1296, DOI 10.1056/NEJMoa041031
   Grundy SM, 2004, CIRCULATION, V109, P551, DOI 10.1161/01.CIR.0000112379.88385.67
   Gyawali P, 2012, CLIN LIPIDOL, V7, P709, DOI 10.2217/CLP.12.65
   Hall JE, 2004, ADV RENAL REPLACE TH, V11, P41, DOI 10.1053/j.arrt.2003.10.007
   Hanefeld M., 2005, METABOLIC SYNDROME B, P347, DOI [10.1016/B978-84-8174-892-5.50021-8, DOI 10.1016/B978-84-8174-892-5.50021-8]
   Hou C, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201800773
   Husi Holger, 2015, J Inj Violence Res, V7, P75, DOI 10.5249/jivr.v7i2.615
   Ichimura T, 1998, J BIOL CHEM, V273, P4135, DOI 10.1074/jbc.273.7.4135
   Jin D, 2020, FOOD FUNCT, V11, P10617, DOI [10.1039/d0fo01275k, 10.1039/D0FO01275K]
   Kaplan M, 2001, J NUTR, V131, P2082, DOI 10.1093/jn/131.8.2082
   Kellum JA, 2021, NAT REV DIS PRIMERS, V7, DOI 10.1038/s41572-021-00284-z
   Kopple JD, 2011, J RENAL NUTR, V21, P66, DOI 10.1053/j.jrn.2010.10.009
   Kopple JD, 2010, J RENAL NUTR, V20, pS29, DOI 10.1053/j.jrn.2010.05.008
   Korshunov SS, 1997, FEBS LETT, V416, P15, DOI 10.1016/S0014-5793(97)01159-9
   Krzywonos-Zawadzka A, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/9617087
   Kulkarni AP, 2004, FOOD CHEM, V87, P551, DOI 10.1016/j.foodchem.2004.01.006
   Lakkis JI, 2018, PROG CARDIOVASC DIS, V61, P157, DOI 10.1016/j.pcad.2018.07.005
   Landecho MF, 2011, REV ESP CARDIOL, V64, P373, DOI 10.1016/j.recesp.2010.11.011
   Lash LH, 2005, TOXICOL APPL PHARM, V204, P329, DOI 10.1016/j.taap.2004.10.004
   Li AN, 2014, NUTRIENTS, V6, P6020, DOI 10.3390/nu6126020
   Li Cavoli G, 2015, BIOIMPACTS, V5, P155, DOI 10.15171/bi.2015.13
   Liu K, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/6713194
   Liu XY, 2019, FREE RADICAL BIO MED, V135, P251, DOI 10.1016/j.freeradbiomed.2019.03.011
   Liu Z., 2021, NRF 2 PLAY PROTECTIV, DOI [10.21203/RS.3.RS-482347/V1, DOI 10.21203/RS.3.RS-482347/V1]
   Locatelli F, 2006, J AM SOC NEPHROL, V17, pS81, DOI 10.1681/ASN.2005121332
   Magtanong L, 2016, CELL DEATH DIFFER, V23, P1099, DOI 10.1038/cdd.2016.25
   Mahesar SA, 2019, FRUIT OILS: CHEMISTRY AND FUNCTIONALITY, P691, DOI 10.1007/978-3-030-12473-1_37
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   Medjakovic S, 2013, FOOD FUNCT, V4, P19, DOI 10.1039/c2fo30034f
   Moilanen J, 2016, PHYTOCHEMISTRY, V125, P65, DOI 10.1016/j.phytochem.2016.02.008
   Mojzer EB, 2016, MOLECULES, V21, DOI 10.3390/molecules21070901
   Nagase M, 2006, J AM SOC NEPHROL, V17, P3438, DOI 10.1681/ASN.2006080944
   Nath KA, 2000, AM J MED, V109, P665, DOI 10.1016/S0002-9343(00)00612-4
   Navaneethan SD, 2010, SEMIN NEPHROL, V30, P51, DOI 10.1016/j.semnephrol.2009.10.008
   Nishida Y, 1999, KIDNEY INT, V56, pS51, DOI 10.1046/j.1523-1755.1999.07113.x
   Oelrichs Peter B., 1994, Natural Toxins, V2, P144, DOI 10.1002/nt.2620020311
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Rodrigo R, 2006, COMP BIOCHEM PHYS C, V142, P317, DOI 10.1016/j.cbpc.2005.11.002
   Rodríguez-Fierros FL, 2021, MOLECULES, V26, DOI 10.3390/molecules26072074
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Santangelo F, 2004, NEPHROL DIAL TRANSPL, V19, P1951, DOI 10.1093/ndt/gfh266
   Sarbijani HM, 2016, DIABETES METAB SYND, V10, pS86, DOI 10.1016/j.dsx.2015.09.024
   Schiffl H, 2017, INT UROL NEPHROL, V49, P461, DOI 10.1007/s11255-016-1451-4
   Scuteri A, 2015, EUR J PREV CARDIOL, V22, P486, DOI 10.1177/2047487314525529
   Shaygannia E, 2016, J EVID-BASED INTEGR, V21, P221, DOI 10.1177/2156587215598039
   Shin JA, 2013, J DIABETES INVEST, V4, P334, DOI 10.1111/jdi.12075
   Siddiqui K, 2020, DIABET METAB SYND OB, V13, P5103, DOI 10.2147/DMSO.S282166
   Silva Junior Geraldo Bezerra da, 2017, Braz. J. Nephrol., V39, P65
   Su LJ, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/5080843
   Tang CY, 2021, NAT REV NEPHROL, V17, P299, DOI 10.1038/s41581-020-00369-0
   Tang JM, 2017, MOL MED REP, V16, P1439, DOI 10.3892/mmr.2017.6687
   Tian C, 2016, SCI REP-UK, V6, DOI 10.1038/srep24353
   Tian C, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0053796
   Tuttle KR, 2005, DIABETES CARE, V28, P2686, DOI 10.2337/diacare.28.11.2686
   Ueno Y, 2002, J NUTR, V132, P897, DOI 10.1093/jn/132.5.897
   Xu J, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11010029
   Yanai H, 2008, NUTR J, V7, DOI 10.1186/1475-2891-7-10
   Yu SMW, 2018, ADV CHRONIC KIDNEY D, V25, P166, DOI 10.1053/j.ackd.2017.12.005
   Zhao Hong, 2013, World J Nephrol, V2, P84, DOI 10.5527/wjn.v2.i3.84
NR 84
TC 14
Z9 14
U1 2
U2 17
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD JAN 5
PY 2023
VL 2023
AR 6144967
DI 10.1155/2023/6144967
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 8C9SG
UT WOS:000917940100006
PM 36644578
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Baughman, P
   Andrew, ME
   Burchfiel, CM
   Fekedulegn, D
   Hartley, TA
   Violanti, JM
   Miller, DB
AF Baughman, Penelope
   Andrew, Michael E.
   Burchfiel, Cecil M.
   Fekedulegn, Desta
   Hartley, Tara A.
   Violanti, John M.
   Miller, Diane B.
TI High-Protein Meal Challenge Reveals the Association Between the Salivary
   Cortisol Response and Metabolic Syndrome in Police Officers
SO AMERICAN JOURNAL OF HUMAN BIOLOGY
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; CARDIOVASCULAR-DISEASE; RISK-FACTORS; ABDOMINAL
   OBESITY; WORK STRESS; POSTTRAUMATIC-STRESS; MEN; NEUROENDOCRINE;
   ATHEROSCLEROSIS; ABNORMALITIES
AB Objectives: Policing is considered a high-stress occupation and officers have elevated cardiovascular morbidity and mortality. To investigate a potential connection, we evaluated the association between salivary cortisol response to a high-protein meal challenge and the metabolic syndrome (MetSyn), a subclinical disorder associated with increased cardiovascular risk.
   Methods: Cross-sectional data were from the Buffalo Cardio-Metabolic Occupational Police Stress (BCOPS) Study (2004-2009). MetSyn was defined as having >= 3 components: abdominal obesity, hypertension, elevated triglycerides, reduced high-density lipoprotein cholesterol, and glucose intolerance. Officers provided five saliva samples for cortisol analysis, one before challenge (high-protein shake) and four at 15-min intervals thereafter, where the usual response is increase. Regression models were used to examine trends in mean number of MetSyn components across quartiles of area under the curve (AUC) salivary cortisol. Patterns of mean cortisol response were assessed by MetSyn status using repeated-measures analysis of covariance.
   Results: Prevalence of MetSyn was 25.7% among 373 officers (74.0% male). The mean count of MetSyn components decreased (1.89, 1.75, 1.55, 1.37; P < 0.01) across increasing quartiles of AUC salivary cortisol. Mean salivary cortisol decreased from baseline (5.55, 4.58, 4.47, 4.79, 4.75 nmol/l) in officers with MetSyn and increased (5.08, 5.82, 5.92, 5.82, 5.60 nmol/l) in their counterparts. The test for interaction between MetSyn status and time of saliva collection was statistically significant (P < 0.001).
   Conclusions: Reduced cortisol response to a high-protein meal challenge may be associated with MetSyn. Future longitudinal studies could provide useful evidence for planning intervention studies on cardiovascular risk among police officers. (C) 2015 Wiley Periodicals, Inc.
C1 [Baughman, Penelope; Andrew, Michael E.; Burchfiel, Cecil M.; Fekedulegn, Desta; Hartley, Tara A.] NIOSH, Biostat & Epidemiol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV USA.
   [Baughman, Penelope] Ctr Dis Control & Prevent, Epidem Intelligence Serv Program, Atlanta, GA USA.
   [Violanti, John M.] SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Epidemiol & Environm Hlth, Buffalo, NY 14260 USA.
   [Miller, Diane B.] NIOSH, Toxicol & Mol Biol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV USA.
C3 Centers for Disease Control & Prevention - USA; National Institute for
   Occupational Safety & Health (NIOSH); Centers for Disease Control &
   Prevention - USA; State University of New York (SUNY) System; University
   at Buffalo, SUNY; Centers for Disease Control & Prevention - USA;
   National Institute for Occupational Safety & Health (NIOSH)
RP Baughman, P (corresponding author), NIOSH, 1095 Willowdale Rd,MS 4050, Morgantown, WV 26505 USA.
EM pbaughman@cdc.gov
OI Baughman, Penelope/0000-0002-5384-3621
FU National Institute for Occupational Safety and Health [200-2003-01580]
FX Contract grant sponsor: National Institute for Occupational Safety and
   Health; Contract grant number: 200-2003-01580.
CR Anagnostis P, 2009, J CLIN ENDOCR METAB, V94, P2692, DOI 10.1210/jc.2009-0370
   [Anonymous], DHHS NIOSH PUBL
   [Anonymous], 1981, HUMAN RESOURCES I MO
   Björntorp P, 2000, INT J OBESITY, V24, pS80, DOI 10.1038/sj.ijo.0801285
   Björntorp P, 2000, BRIT J NUTR, V83, pS49, DOI 10.1017/S0007114500000957
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   de Kloet CS, 2006, J PSYCHIATR RES, V40, P550, DOI 10.1016/j.jpsychires.2005.08.002
   DeSantis AS, 2011, J CLIN ENDOCR METAB, V96, P3483, DOI 10.1210/jc.2011-0483
   DRESSENDORFER RA, 1992, J STEROID BIOCHEM, V43, P683, DOI 10.1016/0960-0760(92)90294-S
   Duclos M, 2005, OBES RES, V13, P1157, DOI 10.1038/oby.2005.137
   Fekedulegn DB, 2007, PSYCHOSOM MED, V69, P651, DOI 10.1097/PSY.0b013e31814c405c
   FOLLENIUS M, 1982, J CLIN ENDOCR METAB, V55, P757, DOI 10.1210/jcem-55-4-757
   Franke WD, 2002, J OCCUP ENVIRON MED, V44, P1182, DOI 10.1097/00043764-200212000-00014
   Gade Wayne, 2010, Clin Lab Sci, V23, P51
   Gershon RRM, 2002, J OCCUP ENVIRON MED, V44, P160, DOI 10.1097/00043764-200202000-00011
   Gibson EL, 1999, PSYCHOSOM MED, V61, P214, DOI 10.1097/00006842-199903000-00014
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hartley Tara A, 2011, Int J Emerg Ment Health, V13, P243
   Hartley Tara A, 2011, Int J Emerg Ment Health, V13, P211
   Joseph PN, 2009, J OCCUP ENVIRON MED, V51, P700, DOI 10.1097/JOM.0b013e3181a02252
   Joseph PN, 2010, J OCCUP ENVIRON MED, V52, P1004, DOI 10.1097/JOM.0b013e3181f4385c
   KIRSCHBAUM C, 1994, PSYCHONEUROENDOCRINO, V19, P313, DOI 10.1016/0306-4530(94)90013-2
   Lee MJ, 2014, BBA-MOL BASIS DIS, V1842, P473, DOI 10.1016/j.bbadis.2013.05.029
   Ljung T, 2000, OBES RES, V8, P487, DOI 10.1038/oby.2000.61
   Marmar CR, 2006, ANN NY ACAD SCI, V1071, P1, DOI 10.1196/annals.1364.001
   McEwen BS, 1998, ANN NY ACAD SCI, V840, P33, DOI 10.1111/j.1749-6632.1998.tb09546.x
   Peter R, 1998, J EPIDEMIOL COMMUN H, V52, P540, DOI 10.1136/jech.52.9.540
   QUIGLEY ME, 1979, J CLIN ENDOCR METAB, V49, P945, DOI 10.1210/jcem-49-6-945
   Rosmond R, 1998, METABOLISM, V47, P1187, DOI 10.1016/S0026-0495(98)90321-3
   Rosmond R, 1998, J CLIN ENDOCR METAB, V83, P1853, DOI 10.1210/jc.83.6.1853
   Rosmond R, 2000, J INTERN MED, V247, P188, DOI 10.1046/j.1365-2796.2000.00603.x
   Sharp DS, 2013, AM J HUM BIOL, V25, P499, DOI 10.1002/ajhb.22397
   Siegrist J, 1997, J INTERN MED, V242, P149, DOI 10.1046/j.1365-2796.1997.00167.x
   U.S. Bureau of Labor Statistics, 2012, OCC OUTL HDB POL DET
   Vrijkotte TGM, 1999, PSYCHOSOM MED, V61, P796, DOI 10.1097/00006842-199911000-00012
   Zimmerman FH, 2012, CARDIOL REV, V20, P159, DOI 10.1097/CRD.0b013e318248d631
NR 38
TC 9
Z9 10
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1042-0533
EI 1520-6300
J9 AM J HUM BIOL
JI Am. J. Hum. Biol.
PD JAN-FEB
PY 2016
VL 28
IS 1
BP 138
EP 144
DI 10.1002/ajhb.22748
PG 7
WC Anthropology; Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Anthropology; Life Sciences & Biomedicine - Other Topics
GA DB4RO
UT WOS:000368501000015
PM 26088798
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Powell, CR
   Kim, A
   Roth, J
   Byrd, JP
   Mohammad, K
   Alloosh, M
   Vittal, R
   Sturek, M
AF Powell, Charles R.
   Kim, Albert
   Roth, Joshua
   Byrd, James P.
   Mohammad, Khalid
   Alloosh, Mouhamad
   Vittal, Ragini
   Sturek, Michael
TI Ossabaw Pig Demonstrates Detrusor Fibrosis and Detrusor Underactivity
   Associated with Oxidative Stress in Metabolic Syndrome
SO COMPARATIVE MEDICINE
LA English
DT Article
ID BLADDER DYSFUNCTION; DIABETES-MELLITUS; WOMEN; MODEL; DIET
AB Metabolic Syndrome (MetS) has detrimental effects on the bladder, including detrusor underactivity. The progression and mechanism of disease are poorly understood. A swine model for diabetic bladder dysfunction (DBD) was established because of the pig's human-sized bladder and its ability to develop MetS by dietary modification alone. The hypothesis of this study is that this swine model will demonstrate oxidative stress associated with MetS, which contributes to both bladder fibrosis and detrusor underactivity (DU). Ossabaw pigs underwent dietary modification consisting of a hypercaloric, atherogenic diet for 10 mo to induce MetS, and were compared with a group of control (lean) pigs. Urodynamic studies were performed in both groups to confirm DU. Thiobarbituric acid reactive substances (TBARS) detected in the urine were used to measure oxidative stress activity in the urinary tract, and urinary IL17a was used to detect profibrotic activity. MetS was confirmed by assessing body weight, blood pressure, glucose tolerance, total cholesterol, and triglycerides. The MetS group exhibited an increase in the relative levels of urinary TBARS and IL17a. Bladder pressures at capacity were lower in the MetS group, suggesting DU. Histologic analysis of a cohort of control (lean) and MetS pigs revealed that as compared with the control pigs, the MetS pigs had significantly more collagen in the muscularis layer, but not in the submucosa or mucosa layer. In conclusion, the Ossabaw pig model for diet-induced MetS is associated with oxidative stress and profibrotic activity in the bladder, which results in DU. This has previously been shown in mice and rats, but never in pigs. This novel model will better represent human MetS and DBD because the mechanism and size of the pig bladder more closely resemble that of a human, resulting in a more valid model and facilitating further study into the signaling mechanisms responsible for this impairment.
C1 [Powell, Charles R.; Roth, Joshua] Indiana Univ, Sch Med, Dept Urol, Indianapolis, IN 46202 USA.
   [Kim, Albert] Temple Univ, Coll Engn, Philadelphia, PA USA.
   [Byrd, James P.; Alloosh, Mouhamad; Sturek, Michael] Indiana Univ, Sch Med, Dept Anat Cell Biol & Physiol, Indianapolis, IN USA.
   [Mohammad, Khalid] Indiana Univ, Sch Med, Dept Med, Endocrinol Div, Indianapolis, IN USA.
   [Sturek, Michael] Purdue Univ, Purdue Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA.
   [Vittal, Ragini] Univ Michigan, Dept Pulm & Crit Care Med, Ann Arbor, MI USA.
C3 Indiana University System; Indiana University Indianapolis; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Temple University;
   Indiana University System; Indiana University Indianapolis; Indiana
   University System; Indiana University Indianapolis; Purdue University
   System; Purdue University; University of Michigan System; University of
   Michigan
RP Powell, CR (corresponding author), Indiana Univ, Sch Med, Dept Urol, Indianapolis, IN 46202 USA.
EM crpowell@iupui.edu
RI Mohammad, Khalid/AFE-4205-2022; Sturek, Michael/CAH-2948-2022; VITTAL,
   RAGINI/AAE-9052-2020; Kim, Albert/Q-9686-2017
OI Kim, Albert/0000-0003-1539-1246; Sturek, Michael/0000-0002-2920-7406; ,
   Khalid/0009-0006-9708-2111
FU Project Development Team within the ICTSI NIH/NCRR Grant [RR025761];
   NIDDK DiaComp Pilot & Feasibility project [DK076169]; NIH [HL062552, UL1
   RR025761, P30 DK097512]; NIH NHLBI [R01HL109288]
FX All authors have read the journal's authorship agreement and policy on
   disclosure of potential conflicts of interest. This project was
   supported by a Project Development Team within the ICTSI NIH/NCRR Grant
   Number RR025761 (Powell, PI) and NIDDK DiaComp Pilot & Feasibility
   project, sub-award DK076169 (Powell, PI) and NIH grant HL062552 (Sturek,
   PI), NIH UL1 RR025761 (Sturek, CO-I), NIH P30 DK097512 (Sturek Co-I),
   NIH NHLBI R01HL109288 (Vittal, PI).
CR [Anonymous], 2011, GUIDE CARE USE LAB A
   Bansal R, 2011, UROLOGY, V77, P699, DOI 10.1016/j.urology.2010.04.062
   Beaver BV, 2001, J AM VET MED ASSOC, V218, P669, DOI 10.2460/javma.2001.218.669
   Beltrán-Sánchez H, 2013, J AM COLL CARDIOL, V62, P697, DOI 10.1016/j.jacc.2013.05.064
   Chang HY, 2008, AM J PHYSIOL-RENAL, V295, pF1248, DOI 10.1152/ajprenal.90259.2008
   Changolkar AK, 2005, J UROLOGY, V173, P309, DOI 10.1097/01.ju.0000141583.31183.7a
   Comeglio P, 2014, PROSTATE, V74, P10, DOI 10.1002/pros.22723
   Daneshgari F, 2006, AM J PHYSIOL-REG I, V290, pR1728, DOI 10.1152/ajpregu.00654.2005
   Daneshgari F, 2009, J UROLOGY, V182, pS8, DOI 10.1016/j.juro.2009.07.084
   Danforth KN, 2009, J UROLOGY, V181, P193, DOI 10.1016/j.juro.2008.09.007
   Fletter Paul C., 2009, 2009 Sixth International Conference on Networked Sensing Systems (INSS), P1, DOI [10.1109/INSS.2009.5409917, DOI 10.1109/INSS.2009.5409917]
   Gasbarro G, 2010, AM J PHYSIOL-RENAL, V298, pF72, DOI 10.1152/ajprenal.00309.2009
   Hanna-Mitchell AT, 2013, AM J PHYSIOL-REG I, V304, pR84, DOI 10.1152/ajpregu.00129.2012
   He CX, 2014, INT UROGYNECOL J, V25, P979, DOI 10.1007/s00192-014-2354-5
   Hong GS, 2010, KOREAN J UROL, V51, P631, DOI 10.4111/kju.2010.51.9.631
   Jiang YH, 2017, J UROLOGY, V197, P197, DOI 10.1016/j.juro.2016.07.071
   Klee NS, 2018, FRONT SURG, V5, DOI 10.3389/fsurg.2018.00072
   Lee SS, 2013, 7 INT C MICR MED BIO
   Lee WC, 2009, J UROLOGY, V181, P198, DOI 10.1016/j.juro.2008.09.021
   Li WJ, 2010, NEUROUROL URODYNAM, V29, P1332, DOI 10.1002/nau.20869
   Liu GM, 2005, AM J PHYSIOL-RENAL, V288, pF1220, DOI 10.1152/ajprenal.00449.2004
   Mattern HM, 2007, MOL CELL BIOCHEM, V302, P43, DOI 10.1007/s11010-007-9423-8
   Morelli A, 2012, J STEROID BIOCHEM, V132, P80, DOI 10.1016/j.jsbmb.2012.02.007
   Otis CR, 2003, COMPARATIVE MED, V53, P53
   PANEPINTO LM, 1982, J NUTR, V112, P2307, DOI 10.1093/jn/112.12.2307
   Philyppov Igor B, 2016, J Smooth Muscle Res, V52, P1, DOI 10.1540/jsmr.52.1
   Powell CR, 2014, CURR BLADDER DYSFUNC, V9, P261, DOI 10.1007/s11884-014-0255-6
   PRYOR WA, 1991, AM J CLIN NUTR, V53, pS391, DOI 10.1093/ajcn/53.1.391S
   Roth J, 2016, J UROLOGY, V195, pE799, DOI 10.1016/j.juro.2016.02.865
   STEERS WD, 1990, J UROLOGY, V143, P1032, DOI 10.1016/S0022-5347(17)40177-7
   Su XL, 2004, AM J PHYSIOL-RENAL, V287, pF690, DOI 10.1152/ajprenal.00027.2004
   Tai HC, 2010, J CLIN ENDOCR METAB, V95, P1143, DOI 10.1210/jc.2009-1492
NR 32
TC 6
Z9 6
U1 0
U2 0
PU AMER ASSOC LABORATORY ANIMAL SCIENCE
PI MEMPHIS
PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA
SN 1532-0820
J9 COMPARATIVE MED
JI Comparative Med.
PD OCT
PY 2020
VL 70
IS 5
BP 329
EP 334
DI 10.30802/AALAS-CM-20-000004
PG 6
WC Veterinary Sciences; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences; Zoology
GA PX0TD
UT WOS:000611076900003
PM 32972487
OA Green Published
DA 2025-06-11
ER

PT J
AU Tarantino, G
   Caputi, A
AF Tarantino, Giovanni
   Caputi, Armando
TI JNKs, insulin resistance and inflammation: A possible link between NAFLD
   and coronary artery disease
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Non-alcoholic fatty liver disease; c-Jun amino-terminal kinase;
   Cardiovascular disease
ID FATTY LIVER-DISEASE; N-TERMINAL KINASE; ENDOPLASMIC-RETICULUM STRESS;
   JUN NH2-TERMINAL KINASE; NONALCOHOLIC STEATOHEPATITIS; CARDIOVASCULAR
   RISK; SIGNALING PATHWAYS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   LIPID-METABOLISM
AB The incidence of obesity has dramatically increased in recent years. Consequently, obesity and associated disorders such as nonalcoholic fatty liver disease constitute a serious problem. Therefore, the contribution of adipose tissue to metabolic homeostasis has become a focus of interest. In this review, we discuss the latest discoveries that support the role of lipids in nonalcoholic fatty liver disease. We describe the common mechanisms (c-Jun amino-terminal kinases, endoplasmic reticulum stress, unfolded protein response, ceramide, low-grade chronic inflammation) by which lipids and their derivatives impair insulin responsiveness and contribute to inflammatory liver and promote plaque instability in the arterial wall. Presenting the molecular mechanism of lipid activation of pro-inflammatory pathways, we attempt to find a link between nonalcoholic fatty liver disease, metabolic syndrome and cardiovascular diseases. Describing the common mechanisms by which lipid derivatives, through modulation of macrophage function, promote plaque instability in the arterial wall, impair insulin responsiveness and contribute to inflammatory liver and discussing the molecular mechanism of lipid activation of pro-inflammatory pathways, the key roles played by the proliferator-activated receptor and liver X receptor alpha, nuclear receptors-lipid sensors that link lipid metabolism and inflammation, should be emphasized. Further studies are warranted of anti-inflammatory drugs such as aspirin, anti-interleukin-6 receptors, immune-modulators (calcineurin inhibitors), substances enhancing the expression of heat shock proteins (which protect cells from endoplasmic reticulum stress-induced apoptosis), and anti- c-Jun amino-terminal kinases in well-designed trials to try to minimize the high impact of these illnesses, and the different expressions of the diseases, on the whole population. (C) 2011 Baishideng. All rights reserved.
C1 [Tarantino, Giovanni] Univ Naples Federico II, Med Sch Naples, Dept Clin & Expt Med, I-80131 Naples, Italy.
   [Caputi, Armando] Univ Naples Federico II, Med Sch Naples, Dept Clin Med Cardiovasc & Immunol Sci, I-80131 Naples, Italy.
C3 University of Naples Federico II; University of Naples Federico II
RP Tarantino, G (corresponding author), Univ Naples Federico II, Med Sch Naples, Dept Clin & Expt Med, Via Sergio Pansini 5, I-80131 Naples, Italy.
EM tarantin@unina.it
RI Tarantino, Giovanni/AAW-2007-2021
CR Abdelli S, 2004, DIABETES, V53, P2815, DOI 10.2337/diabetes.53.11.2815
   Baker AR, 2009, J CLIN ENDOCR METAB, V94, P261, DOI 10.1210/jc.2007-2579
   Belgardt BF, 2010, AGING-US, V2, P621, DOI 10.18632/aging.100192
   Bennett BL, 2003, CURR OPIN PHARMACOL, V3, P420, DOI 10.1016/S1471-4892(03)00068-7
   Berdichevsky A, 2010, J BIOL CHEM, V285, P21581, DOI 10.1074/jbc.M109.093633
   Bode AM, 2007, MOL CARCINOGEN, V46, P591, DOI 10.1002/mc.20348
   Boden G, 2008, DIABETES, V57, P2438, DOI 10.2337/db08-0604
   Chen WQ, 2010, HEPATOLOGY, V52, P1134, DOI 10.1002/hep.23812
   Cheung O, 2008, SEMIN LIVER DIS, V28, P351, DOI 10.1055/s-0028-1091979
   Cho H, 2008, AM J PHYSIOL-ENDOC M, V295, pE1142, DOI 10.1152/ajpendo.90298.2008
   Choi SS, 2008, CURR OPIN LIPIDOL, V19, P295, DOI 10.1097/MOL.0b013e3282ff5e55
   Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI23621
   Flamment M, 2010, CURR OPIN LIPIDOL, V21, P239, DOI 10.1097/MOL.0b013e3283395e5c
   Gubern A, 2009, J BIOL CHEM, V284, P32359, DOI 10.1074/jbc.M109.061515
   Hahn C, 2009, CIRC RES, V104, P995, DOI 10.1161/CIRCRESAHA.108.186486
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Jaeschke A, 2005, P NATL ACAD SCI USA, V102, P6931, DOI 10.1073/pnas.0502143102
   Johnson GL, 2007, BBA-MOL CELL RES, V1773, P1341, DOI 10.1016/j.bbamcr.2006.12.009
   Kaneto H, 2002, J BIOL CHEM, V277, P30010, DOI 10.1074/jbc.M202066200
   Kodama Y, 2009, GASTROENTEROLOGY, V137, P1467, DOI 10.1053/j.gastro.2009.06.045
   Komiya K, 2010, BIOCHEM BIOPH RES CO, V401, P561, DOI 10.1016/j.bbrc.2010.09.101
   Lass A, 2011, PROG LIPID RES, V50, P14, DOI 10.1016/j.plipres.2010.10.004
   Levitan EB, 2009, CIRC-HEART FAIL, V2, P202, DOI 10.1161/CIRCHEARTFAILURE.108.794099
   Maedler K, 2008, FASEB J, V22, P1905, DOI 10.1096/fj.07-101824
   Malhi H, 2006, J BIOL CHEM, V281, P12093, DOI 10.1074/jbc.M510660200
   Martinon F, 2011, CURR OPIN IMMUNOL, V23, P35, DOI 10.1016/j.coi.2010.10.016
   Mottillo EP, 2010, BBA-MOL CELL BIOL L, V1801, P1048, DOI 10.1016/j.bbalip.2010.04.012
   Nguyen MTA, 2005, J BIOL CHEM, V280, P35361, DOI 10.1074/jbc.M504611200
   Nogueira TCA, 2009, PANCREAS, V38, P585, DOI 10.1097/MPA.0b013e31819fef03
   Oktay K, 2008, CELL CYCLE, V7, P533, DOI 10.4161/cc.7.4.5660
   Olive DM, 2004, EXPERT REV PROTEOMIC, V1, P327, DOI 10.1586/14789450.1.3.327
   Park Seung Ha, 2004, Korean Journal of Internal Medicine, V19, P75
   Petersen KF, 2006, AM J MED, V119, p10S, DOI 10.1016/j.amjmed.2006.01.009
   Popa C, 2007, J LIPID RES, V48, P751, DOI 10.1194/jlr.R600021-JLR200
   Prieur X, 2010, BBA-MOL CELL BIOL L, V1801, P327, DOI 10.1016/j.bbalip.2009.09.017
   Putcha GV, 2003, NEURON, V38, P899, DOI 10.1016/S0896-6273(03)00355-6
   Romeo S, 2010, CURR OPIN LIPIDOL, V21, P247, DOI 10.1097/MOL.0b013e328338ca61
   Ruvolo PP, 2001, LEUKEMIA, V15, P1153, DOI 10.1038/sj.leu.2402197
   Sanyal AJ, 2001, GASTROENTEROLOGY, V120, P1183, DOI 10.1053/gast.2001.23256
   Schattenberg JM, 2006, HEPATOLOGY, V43, P163, DOI 10.1002/hep.20999
   Soon RK, 2010, GASTROENTEROLOGY, V139, P1730, DOI 10.1053/j.gastro.2010.07.046
   Swindell WR, 2009, AGING-US, V1, P573, DOI 10.18632/aging.100058
   Tan Ying, 2009, Zhonghua Gan Zang Bing Za Zhi, V17, P821
   Tanti JF, 2009, CURR OPIN PHARMACOL, V9, P753, DOI 10.1016/j.coph.2009.07.004
   Tarantino G, 2010, INT J IMMUNOPATH PH, V23, P1303, DOI 10.1177/039463201002300440
   Tarantino G, 2007, WORLD J GASTROENTERO, V13, P4669, DOI 10.3748/wjg.v13.i35.4669
   Tarantino G, 2007, J GASTROEN HEPATOL, V22, P293, DOI 10.1111/j.1440-1746.2007.04824.x
   Tarantino G, 2009, EUR J GASTROEN HEPAT, V21, P504, DOI 10.1097/MEG.0b013e3283229b40
   Tarantino G, 2008, J TRANSL MED, V6, DOI 10.1186/1479-5876-6-72
   Teramoto H, 1996, J BIOL CHEM, V271, P25731, DOI 10.1074/jbc.271.42.25731
   Tsai J, 2007, ARTERIOSCL THROM VAS, V27, P211, DOI 10.1161/01.ATV.0000249861.80471.96
   Urano F, 2000, SCIENCE, V287, P664, DOI 10.1126/science.287.5453.664
   Wang Y, 2008, J NUTR, V138, P1866, DOI 10.1093/jn/138.10.1866
   Weickert MO, 2006, DIABETOLOGIA, V49, P1732, DOI 10.1007/s00125-006-0295-3
   Yu XX, 2008, AM J PHYSIOL-ENDOC M, V295, pE436, DOI 10.1152/ajpendo.00629.2007
   Zhang CX, 2008, EUR J NUTR, V47, P244, DOI 10.1007/s00394-008-0718-7
NR 56
TC 116
Z9 127
U1 0
U2 15
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD SEP 7
PY 2011
VL 17
IS 33
BP 3785
EP 3794
DI 10.3748/wjg.v17.i33.3785
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 834OM
UT WOS:000295971500003
PM 21987620
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Selvaraju, V
   Joshi, M
   Suresh, S
   Sanchez, JA
   Maulik, N
   Maulik, G
AF Selvaraju, Vaithinathan
   Joshi, Mandip
   Suresh, Sumanth
   Sanchez, Juan A.
   Maulik, Nilanjana
   Maulik, Gautam
TI Diabetes, oxidative stress, molecular mechanism, and cardiovascular
   disease - an overview
SO TOXICOLOGY MECHANISMS AND METHODS
LA English
DT Review
DE Oxidative stress; diabetes; hyperglycemia; cardiovascular disease;
   reactive oxygen species
ID TUMOR-NECROSIS-FACTOR; ENDOTHELIAL DYSFUNCTION; LIPID-PEROXIDATION;
   METABOLIC SYNDROME; NAD(P)H OXIDASE; FREE-RADICALS; KAPPA-B; RATS;
   ANTIOXIDANT; CARDIOMYOPATHY
AB In recent years, diabetes and its associated complications have come to represent a major public health concern. It is a complex disease characterized by multiple metabolic derangements and is known to impair cardiac function by disrupting the balance between pro-oxidants and antioxidants at the cellular level. The subsequent generation of reactive oxygen species (ROS) and accompanying oxidative stress are hallmarks of the molecular mechanisms responsible for cardiovascular disease. Among several oxidative stress-mediated mechanisms that have been proposed, ROS-mediated oxidative stress has received the most attention. ROS have been shown to interact with proteins, lipids, and DNA, causing damage to the cellular macromolecules and subsequently, deterioration of cellular function. Induction of thioredoxin-1 (Trx1) gene expression has been demonstrated to protect the diabetic myocardium from dysfunction by reducing oxidative stress and enhancing the expression of heme oxygenase-1 (HO-1) and vascular endothelial growth factor (VEGF). The failure of antioxidants to consistently demonstrate clinical benefit necessitates further investigation of the role of oxidative stress in diabetes-mediated cardiovascular disease.
C1 [Maulik, Gautam] Harvard Univ, Sch Med, Dept Radiol, Boston, MA 02115 USA.
   [Selvaraju, Vaithinathan; Joshi, Mandip; Suresh, Sumanth; Sanchez, Juan A.; Maulik, Nilanjana] Univ Connecticut, Ctr Hlth, Dept Surg, Mol Cardiol & Angiogenesis Lab, Farmington, CT USA.
C3 Harvard University; Harvard Medical School; University of Connecticut
RP Maulik, G (corresponding author), Harvard Univ, Sch Med, Dept Radiol, 200 Longwood Ave, Boston, MA 02115 USA.
RI Vaithinathan, Selvaraju/D-4277-2013; Sanchez, Juan/AAQ-1488-2020;
   Sanchez, Juan/I-1936-2016
OI Sanchez, Juan/0000-0002-6789-3208
CR Adluri RS, 2011, J MOL CELL CARDIOL, V50, P239, DOI 10.1016/j.yjmcc.2010.11.002
   Anderson RA, 2001, J AM COLL NUTR, V20, P212, DOI 10.1080/07315724.2001.10719034
   Aragno M, 2004, DIABETES, V53, P1082, DOI 10.2337/diabetes.53.4.1082
   Aragno M, 2000, DIABETES, V49, P1924, DOI 10.2337/diabetes.49.11.1924
   BARTELS GL, 1992, J CARDIOVASC PHARM, V20, P157, DOI 10.1097/00005344-199207000-00020
   Battiprolu P.K., 2010, DRUG DISCOV TODAY DI, V7, pe135, DOI DOI 10.1016/J.DDMEC.2010.08.001
   Boudina S, 2007, CIRCULATION, V115, P3213, DOI 10.1161/CIRCULATIONAHA.106.679597
   Brignardello E, 2000, J ENDOCRINOL, V166, P401, DOI 10.1677/joe.0.1660401
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Brownlee M, 2005, DIABETES, V54, P1615, DOI 10.2337/diabetes.54.6.1615
   BUCALA R, 1993, P NATL ACAD SCI USA, V90, P6434, DOI 10.1073/pnas.90.14.6434
   Cave AC, 2006, ANTIOXID REDOX SIGN, V8, P691, DOI 10.1089/ars.2006.8.691
   Ceriello A, 2003, DIABETES CARE, V26, P1589, DOI 10.2337/diacare.26.5.1589
   Coughlin Steven S., 1994, Annals of Epidemiology, V4, P67
   De Rekeneire N, 2006, J NUTR HEALTH AGING, V10, P285
   Di Wu Q, 1999, AM J PHYSIOL-CELL PH, V277, pC1229, DOI 10.1152/ajpcell.1999.277.6.C1229
   Esposito K, 2002, CIRCULATION, V106, P2067, DOI 10.1161/01.CIR.0000034509.14906.AE
   Farahmand F, 2003, ATHEROSCLEROSIS HYPE
   Fuliang HU, 2005, PHARMACOL RES, V51, P147, DOI 10.1016/j.phrs.2004.06.011
   Gao L, 2009, CARDIOVASC RES, V82, P9, DOI 10.1093/cvr/cvp031
   Gao X, 2007, CIRCULATION, V115, P245, DOI 10.1161/CIRCULATIONAHA.106.650671
   Green K, 2004, DIABETES, V53, pS110, DOI 10.2337/diabetes.53.2007.S110
   Hallenbeck JM, 2002, NAT MED, V8, P1363, DOI 10.1038/nm1202-1363
   Halliwell B, 1996, ANNU REV NUTR, V16, P33, DOI 10.1146/annurev.nu.16.070196.000341
   Hansson GK, 2005, NEW ENGL J MED, V352, P1685, DOI 10.1056/NEJMra043430
   Hink U, 2001, CIRC RES, V88, pE14
   Ichikawa T, 1999, INT J ANDROL, V22, P37
   Indulekha K, 2011, CLIN BIOCHEM, V44, P281, DOI 10.1016/j.clinbiochem.2010.12.015
   Inoguchi T, 2000, DIABETES, V49, P1939, DOI 10.2337/diabetes.49.11.1939
   Ishii H, 1998, J MOL MED, V76, P21, DOI 10.1007/s109-1998-8101-y
   Ishii H, 1996, SCIENCE, V272, P728, DOI 10.1126/science.272.5262.728
   Iwasaki Y, 2004, J CLIN ENDOCR METAB, V89, P3449, DOI 10.1210/jc.2003-031441
   Johansen JS, 2005, CARDIOVASC DIABETOL, V4, DOI 10.1186/1475-2840-4-5
   KAKKAR R, 1995, MOL CELL BIOCHEM, V151, P113, DOI 10.1007/BF01322333
   Kaul N, 1996, MOL CELL BIOCHEM, V161, P283, DOI 10.1007/BF00240060
   Kaul N, 1995, NUTRITION, V11, P551
   King H, 1998, DIABETES CARE, V21, P1414, DOI 10.2337/diacare.21.9.1414
   Lipinski B, 2011, OXID MED CELL LONGEV, V2011, DOI 10.1155/2011/809696
   Luther JM, 2011, TRENDS PHARMACOL SCI, V32, P734, DOI 10.1016/j.tips.2011.07.006
   Maack C, 2003, CIRCULATION, V108, P1567, DOI 10.1161/01.CIR.0000091084.46500.BB
   Matsui H, 1997, CAN J CARDIOL, V13, P373
   Mauldin JP, 2008, CIRCULATION, V117, P2785, DOI 10.1161/CIRCULATIONAHA.107.741314
   Menke T, 2008, PEDIATR DIABETES, V9, P540, DOI 10.1111/j.1399-5448.2008.00389.x
   Miwa S, 2005, ENDOCR J, V52, P259, DOI 10.1507/endocrj.52.259
   Natali A, 2000, DIABETOLOGIA, V43, P632, DOI 10.1007/s001250051352
   Newsholme P, 2007, J PHYSIOL-LONDON, V583, P9, DOI 10.1113/jphysiol.2007.135871
   Nishikawa T, 2000, KIDNEY INT, V58, pS26, DOI 10.1046/j.1523-1755.2000.07705.x
   OHKUWA T, 1995, LIFE SCI, V56, P1789, DOI 10.1016/0024-3205(95)00150-5
   Park Y, 2008, AM J PHYSIOL-HEART C, V295, pH1982, DOI 10.1152/ajpheart.01261.2007
   Picchi A, 2006, CIRC RES, V99, P69, DOI 10.1161/01.RES.0000229685.37402.80
   Qian SH, 2011, J ETHNOPHARMACOL, V137, P985, DOI 10.1016/j.jep.2011.07.018
   Rahman I, 2002, MOL CELL BIOCHEM, V234, P239, DOI 10.1023/A:1015905010086
   Ramasamy R, 2009, J LEUKOCYTE BIOL, V86, P505, DOI 10.1189/jlb.0409230
   Rauscher FM, 2001, J BIOCHEM MOL TOXIC, V15, P41, DOI 10.1002/1099-0461(2001)15:1<41::AID-JBT5>3.3.CO;2-Q
   Roebuck KA, 1999, INT J MOL MED, V4, P223
   RUBLER S, 1972, AM J CARDIOL, V30, P595, DOI 10.1016/0002-9149(72)90595-4
   Samuel SM, 2010, CIRCULATION, V121, P1244, DOI 10.1161/CIRCULATIONAHA.109.872481
   SINGAL PK, 1988, MOL CELL BIOCHEM, V84, P121, DOI 10.1007/BF00421045
   Son SM, 2007, DIABETES RES CLIN PR, V77, pS65, DOI 10.1016/j.diabres.2007.01.036
   Taddei S, 1998, CIRCULATION, V97, P2222, DOI 10.1161/01.CIR.97.22.2222
   Tan KCB, 2002, DIABETES CARE, V25, P1055, DOI 10.2337/diacare.25.6.1055
   Taniguchi N, 1996, DIABETES, V45, pS81, DOI 10.2337/diab.45.3.S81
   Touyz RM, 2004, HYPERTENSION, V44, P248, DOI 10.1161/01.HYP.0000138070.47616.9d
   Tripathy D, 2003, DIABETES, V52, P2882, DOI 10.2337/diabetes.52.12.2882
   Vinik A, 2002, J DIABETES COMPLICAT, V16, P235, DOI 10.1016/S1056-8727(01)00212-4
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Westermann D, 2007, BASIC RES CARDIOL, V102, P500, DOI 10.1007/s00395-007-0673-0
   Wu JHY, 2007, CLIN CHEM, V53, P511, DOI 10.1373/clinchem.2006.076992
   Yamagishi S, 2001, DIABETES, V50, P1491, DOI 10.2337/diabetes.50.6.1491
   Yiginer O, 2008, CLIN RES CARDIOL, V97, P334, DOI 10.1007/s00392-007-0636-3
   Yorek MA, 2002, AM J PHYSIOL-ENDOC M, V283, pE1067, DOI 10.1152/ajpendo.00173.2002
NR 71
TC 81
Z9 96
U1 0
U2 43
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1537-6516
EI 1537-6524
J9 TOXICOL MECH METHOD
JI Toxicol. Mech. Methods
PD JUN
PY 2012
VL 22
IS 5
BP 330
EP 335
DI 10.3109/15376516.2012.666648
PG 6
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA 939SQ
UT WOS:000303835200003
PM 22394340
DA 2025-06-11
ER

PT J
AU Pomngen, I
   Sirisatayawong, P
   Kumsaiyai, W
   Kaunnil, A
   Srikhamjak, T
AF Pomngen, Ilada
   Sirisatayawong, Pornpen
   Kumsaiyai, Warunee
   Kaunnil, Anuchart
   Srikhamjak, Tiam
TI Relationships between sensory processing patterns and metabolic risk
   factors among community dwelling people with metabolic syndrome: A
   cross-sectional and correlational research design
SO PLOS ONE
LA English
DT Article
ID PHYSICAL-ACTIVITY; SEDENTARY BEHAVIOR; BLOOD-PRESSURE; SENSITIVITY;
   STRESS; TIME; ASSOCIATIONS; PERCEPTION; HEALTH; LIFE
AB Background Metabolic Syndrome (MetS) increases the risk of other serious health problems, particularly cardiovascular diseases and stroke. Sensory processing patterns (SPPs) are internal factors shaping behaviors and emotions, both healthy and unhealthy. There is a lack of studies directly examining the relationship between the SPPs and metabolic risk factors. Method This study aimed to investigate SPPs and their association with metabolic risk factors in individuals with metabolic syndrome (MetS). One hundred and seventeen individuals with MetS completed questionnaires on demographic characteristics and the Thai Sensory Patterns Assessment-adult version. Data on metabolic risk factors, including fasting blood glucose, blood pressure, and waist circumference, were collected. Results The findings revealed high arousal levels in proprioceptive and auditory senses among the participants. The fasting blood glucose was significantly correlated with a preference in the tactile sense (r = -0.150, P<0.05), while waist circumference was associated with arousal level in the auditory and smell-taste senses (r = 0.140, -0.160, P<0.05). Moreover, the GLMM revealed that fasting blood glucose was associated with preferences in tactile, vestibular, and proprioceptive senses (r = -0.481, 0.726, -0.386, P<0.05). Furthermore, diastolic blood pressure was associated with preferences in vestibular sense (r = 0.099; P<0.05). Conclusion The SPPs might be related to metabolic risk factors, so it is important to recognize how individual SPPs relate to metabolic risk factors. However, further studies using a larger sample may be needed to deeply explore the mechanisms underlying these associations.
C1 [Pomngen, Ilada; Sirisatayawong, Pornpen; Kaunnil, Anuchart; Srikhamjak, Tiam] Chiang Mai Univ, Fac Associated Med Sci, Dept Occupat Therapy, Chiang Mai, Thailand.
   [Kumsaiyai, Warunee] Chiang Mai Univ, Fac Associated Med Sci, Dept Med Technol, Chiang Mai, Thailand.
C3 Chiang Mai University; Chiang Mai University
RP Srikhamjak, T (corresponding author), Chiang Mai Univ, Fac Associated Med Sci, Dept Occupat Therapy, Chiang Mai, Thailand.
EM tiamsrikhamjak@gmail.com
RI KAUNNIL, ANUCHART/B-1818-2016
OI KAUNNIL, ANUCHART/0000-0002-8178-6513; pomngen,
   ilada/0000-0003-0280-6297
FU Faculty of Associated Medical Sciences, Chiang Mai University;
   Department of Occupational Therapy, Faculty of Associated Medical
   Sciences, Chiang Mai University
FX This research was supported by the Department of Occupational Therapy,
   Faculty of Associated Medical Sciences, Chiang Mai University.
CR Aekplakorn W, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-854
   Al Suwaidi J, 2010, J CLIN HYPERTENS, V12, P890, DOI 10.1111/j.1751-7176.2010.00371.x
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Aljuhani O, 2020, RISK MANAG HEALTHC P, V13, P1839, DOI 10.2147/RMHP.S267575
   Aron EN, 2012, PERS SOC PSYCHOL REV, V16, P262, DOI 10.1177/1088868311434213
   Bai J, 2021, BIOMED ENVIRON SCI, V34, P963, DOI 10.3967/bes2021.132
   Beales PF, 2000, T ROY SOC TROP MED H, V94, pS1
   Benham G, 2006, PERS INDIV DIFFER, V40, P1433, DOI 10.1016/j.paid.2005.11.021
   Boongerd P., 2018, Dementia Association of Thailand, V10, P1
   Boongerd P, Dementia Association of Thailand Newslette Internet
   Brown C, 2001, AM J OCCUP THER, V55, P75, DOI 10.5014/ajot.55.1.75
   Brown C., 2002, Occupational Therapy in Mental Health, V17, P115, DOI DOI 10.1300/J004V17N03_08
   Brunda NSS., 2019, Natl J Physiol Pharm Pharmacol, V9, P276
   Campbell S, 2020, J RES NURS, V25, P652, DOI 10.1177/1744987120927206
   Corbett BA, 2009, AUTISM RES, V2, P39, DOI 10.1002/aur.64
   Dunn W, 2001, AM J OCCUP THER, V55, P608, DOI 10.5014/ajot.55.6.608
   Dunn W., 1997, Occupational therapy: Enabling function and well-being, P182
   Dunn W., 2008, Living sensationally
   Engel-Yeger B, 2017, CAN J OCCUP THER, V84, P10, DOI 10.1177/0008417417690415
   Engel-Yeger B, 2011, BRIT J OCCUP THER, V74, P456, DOI 10.4276/030802211X13182481841868
   Ershova RV, 2018, ELECTRON J GEN MED, V15, DOI 10.29333/ejgm/100634
   Fallah Z, 2022, BMC NUTR, V8, DOI 10.1186/s40795-022-00609-5
   FISHER W, 1992, J APPL BEHAV ANAL, V25, P491, DOI 10.1901/jaba.1992.25-491
   Fritschi C, 2016, BIOL RES NURS, V18, P160, DOI 10.1177/1099800415600065
   Goldberg A, 2018, J PEDIATR NURS, V38, pE35, DOI 10.1016/j.pedn.2017.10.015
   Guembe MJ, 2020, CARDIOVASC DIABETOL, V19, DOI 10.1186/s12933-020-01166-6
   Hebert KR, 2018, BRIT J OCCUP THER, V81, P162, DOI 10.1177/0308022617743708
   Just T, 2008, APPETITE, V51, P622, DOI 10.1016/j.appet.2008.04.271
   Kanchanawong T., 2022, PREPRINT, DOI [10.1101/2022.06.05.22275861v2.full, DOI 10.1101/2022.06.05.22275861V2.FULL]
   Kidd T, 2023, HEALTH PSYCHOL REV, V17, P60, DOI 10.1080/17437199.2022.2143854
   Kuo WC, 2019, OBES REV, V20, P1651, DOI 10.1111/obr.12915
   Lawson LM, 2016, AM J OCCUP THER, V70, DOI 10.5014/ajot.2016.021535
   Lemes IR, 2019, PUBLIC HEALTH, V167, P96, DOI 10.1016/j.puhe.2018.11.007
   Li X, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.704145
   Lin HL, 2017, HYPERTENSION, V69, P806, DOI [10.1161/HYPERTENSIONAHA.116.08839, 10.1161/hypertensionaha.116.08839]
   Liu J, 2022, FOOD QUAL PREFER, V100, DOI 10.1016/j.foodqual.2022.104624
   Lundy-Ekman L., 2013, NEUROSCIENCE FUNDAME, V4
   Machingura T., 2019, Irish Journal of Occupational Therapy, DOI [DOI 10.1108/IJOT-12-2018-0025, 10.1108/IJOT-12-2018-0025]
   Nadon Genevieve, 2011, Autism Res Treat, V2011, P541926, DOI 10.1155/2011/541926
   Naish KR, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043622
   Navarrete-Muñoz EM, 2020, NUTRIENTS, V12, DOI 10.3390/nu12123684
   Ngoc HN., 2021, J Health Sci Med Res JHSMR, V39, P13
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Ogedegbe G, 2010, CARDIOL CLIN, V28, P571, DOI 10.1016/j.ccl.2010.07.006
   Owlasiuk A, 2014, ANN AGR ENV MED, V21, P353, DOI 10.5604/1232-1966.1108604
   PACE GM, 1985, J APPL BEHAV ANAL, V18, P249, DOI 10.1901/jaba.1985.18-249
   Paul R., 2020, J NAT SCI BIOL MED, V11, P111, DOI [10.4103/jnsbm.JNSBM_205_19, DOI 10.4103/JNSBM.JNSBM_205_19]
   Pomngen I., 2020, M. Sc. Thesis
   Rohde K, 2020, DIABETES METAB J, V44, P509, DOI 10.4093/dmj.2020.0058
   Rosmond R, 2005, PSYCHONEUROENDOCRINO, V30, P1, DOI 10.1016/j.psyneuen.2004.05.007
   Sartor F, 2011, APPETITE, V57, P237, DOI 10.1016/j.appet.2011.05.107
   Sergi G, 2017, CRIT REV FOOD SCI, V57, P3684, DOI 10.1080/10408398.2016.1160208
   Skrandies W, 2015, PHYSIOL BEHAV, V142, P1, DOI 10.1016/j.physbeh.2015.01.024
   Srikhamjak T, 2022, EUR J INVEST HEALTH, V12, P1682, DOI 10.3390/ejihpe12110118
   Stern BZ, 2021, J HEALTH PSYCHOL, V26, P2106, DOI 10.1177/1359105319901316
   Sutthachai R, 2022, HEALTHCARE-BASEL, V10, DOI 10.3390/healthcare10101968
   van den Boogert F, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19042043
   Yates BJ, 2014, COMPR PHYSIOL, V4, P851, DOI 10.1002/cphy.c130041
   Zhang FF, 2021, NEUROLOGY, V97, pE695, DOI 10.1212/WNL.0000000000012415
   Zickgraf HF, 2016, FOOD QUAL PREFER, V54, P39, DOI 10.1016/j.foodqual.2016.06.012
NR 60
TC 0
Z9 0
U1 1
U2 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 6
PY 2024
VL 19
IS 9
AR e0308421
DI 10.1371/journal.pone.0308421
PG 19
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA H9O4X
UT WOS:001326653200136
PM 39241047
OA gold
DA 2025-06-11
ER

PT J
AU Wang, AQ
   Liu, M
   Shang, WT
   Liu, JG
   Dai, Z
   Strappe, P
   Zhou, ZK
AF Wang, Anqi
   Liu, Min
   Shang, Wenting
   Liu, Jinguang
   Dai, Zhen
   Strappe, Padraig
   Zhou, Zhongkai
TI Attenuation of metabolic syndrome in the ob/ob mouse model by resistant
   starch intervention is dose dependent
SO FOOD & FUNCTION
LA English
DT Article
ID MECHANISMS LINKING OBESITY; DIET-INDUCED OBESITY; CHAIN FATTY-ACIDS;
   INSULIN-RESISTANCE; WEIGHT; MICE; OVEREXPRESSION; ASSOCIATIONS; STRESS;
   RISK
AB The current study applied an ob/ob mouse model of obesity for investigating the impact of different RS doses in a high-fat (HF) diet on the attenuation of metabolic syndrome. Although a significant reduction of body weight was not achieved, RS intervention significantly decreased liver weight with suppressed lipid accumulation in the liver tissue and reduced adipocyte size in the fat tissue. All levels of RS intervention were associated with significantly enriched pathways for PPAR, NAFLD and cGMP-PKG signaling. In contrast, either a medium or a higher RS intake (MRS and HRS, respectively) led the AMPK signaling pathway to be significantly enriched but not a diet with lower RS intake. More importantly, sphingolipid biosynthesis activity was noted with MRS and HRS intervention, which is highly associated with the improvement in insulin resistance, and the pathway of type II diabetes mellitus was correspondingly significantly enriched in the HRS group, demonstrating a dose-dependent manner. Similarly, there was no significant difference in the ratio of Bacteroidetes and Firmicutes between high-fat diet and RS groups until RS reached a certain level (i.e. in the HRS group). Furthermore, increased profiles of both Prevotellaceae and Coriobacteriaceae in the HF group were noted for the first time with a revised function from RS intervention, which is consistent with the content of lipopolysaccharides in their corresponding serum. Gut microbiota functional analysis showed that primary and secondary bile acid biosynthesis was also noted to be enriched following the RS intervention, benefiting cholesterol homeostasis. This study further highlights the association of RS consumption with the attenuation of metabolic syndrome in an obesity model, and its functionality is characterized by dose-dependence.
C1 [Wang, Anqi; Liu, Min; Shang, Wenting; Liu, Jinguang; Dai, Zhen; Zhou, Zhongkai] Tianjin Univ Sci & Technol, Coll Food Engn & Biotechnol, Tianjin 300457, Peoples R China.
   [Strappe, Padraig] Cent Queensland Univ, Sch Med & Appl Sci, Rockhampton, Qld 4700, Australia.
   [Zhou, Zhongkai] Charles Sturt Univ, ARC Funct Grains Ctr, Wagga Wagga, NSW 2678, Australia.
C3 Tianjin University Science & Technology; Central Queensland University;
   Charles Sturt University
RP Zhou, ZK (corresponding author), Tianjin Univ Sci & Technol, Coll Food Engn & Biotechnol, Tianjin 300457, Peoples R China.; Zhou, ZK (corresponding author), Charles Sturt Univ, ARC Funct Grains Ctr, Wagga Wagga, NSW 2678, Australia.
EM zzhou@csu.edu.au
RI Zhou, Zhongkai/AAC-1412-2019; Dai, Zhen/AAS-4858-2020; Shang,
   Wenting/E-8475-2018; min, liu/AAX-1641-2021
OI Zhou, Zhongkai/0000-0003-1918-413X; Wang, Anqi/0000-0002-7967-570X
FU National Key Research and Development Program [2016YFD0400401-2];
   National Nature Science Foundation of China [U1501214]
FX This work was financially supported by the National Key Research and
   Development Program (2016YFD0400401-2) and the National Nature Science
   Foundation of China (No. U1501214).
CR [Anonymous], J PEDIAT GASTROENTER
   [Anonymous], COCHRANE DATABASE SY
   Ashwar BA, 2016, STARCH-STARKE, V68, P287, DOI 10.1002/star.201500064
   Aziz AA, 2009, J NUTR, V139, P1881, DOI 10.3945/jn.109.110650
   Belobrajdic DP, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-93
   Ben Mohamed A, 2019, J NUTR BIOCHEM, V65, P72, DOI 10.1016/j.jnutbio.2018.12.002
   Byrne CS, 2015, INT J OBESITY, V39, P1331, DOI 10.1038/ijo.2015.84
   Chopra M, 2002, B WORLD HEALTH ORGAN, V80, P952
   Cox LM, 2013, CELL METAB, V17, P883, DOI 10.1016/j.cmet.2013.05.004
   Denis GV, 2013, MOL ASPECTS MED, V34, P59, DOI 10.1016/j.mam.2012.10.004
   Duncan SH, 2008, INT J OBESITY, V32, P1720, DOI 10.1038/ijo.2008.155
   Engelking LJ, 2005, J CLIN INVEST, V115, P2489, DOI 10.1172/JCI25614
   Fabbrini E, 2010, HEPATOLOGY, V51, P679, DOI 10.1002/hep.23280
   Finlayson A, 2015, WORLD J GASTRO ENDOS, V7, P1103, DOI [10.4291/wjgp.v6.i4.110, 10.4253/wjge.v7.i13.1103]
   Flynn MAT, 2006, OBES REV, V7, P7, DOI 10.1111/j.1467-789X.2006.00242.x
   Fu SN, 2011, NATURE, V473, P528, DOI 10.1038/nature09968
   Goldsmith F, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201501025
   Hegele RA, 2001, J HUM GENET, V46, P320, DOI 10.1007/s100380170066
   Jenkins DJA, 2000, CURR OPIN GASTROEN, V16, P178, DOI 10.1097/00001574-200003000-00014
   Kahn SE, 2006, NATURE, V444, P840, DOI 10.1038/nature05482
   Kieffer DA, 2016, J NUTR, V146, P2476, DOI 10.3945/jn.116.238931
   Kimura I, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms2852
   Kirpich IA, 2011, J NUTR BIOCHEM, V22, P38, DOI 10.1016/j.jnutbio.2009.11.009
   Kivipelto M, 2005, ARCH NEUROL-CHICAGO, V62, P1556, DOI 10.1001/archneur.62.10.1556
   Kursawe R, 2013, DIABETES, V62, P837, DOI 10.2337/db12-0889
   Lecomte V, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0126931
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Liu H, 2018, ADV NUTR, V9, P21, DOI 10.1093/advances/nmx009
   Liu YH, 2013, BIOCHEM BIOPH RES CO, V438, P78, DOI 10.1016/j.bbrc.2013.07.029
   Lyte M, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0146406
   Martin GG, 2017, J LIPID RES, V58, P2114, DOI 10.1194/jlr.M077891
   McIntosh AL, 2013, LIPIDS, V48, P435, DOI 10.1007/s11745-013-3777-3
   Ng M, 2014, Lancet (London, England), V384
   Obanda D, 2018, OBESITY, V26, P570, DOI 10.1002/oby.22120
   Ojo B, 2017, BRIT J NUTR, V118, P241, DOI 10.1017/S0007114517002082
   Rossi EL, 2016, CANCER RES, V76, DOI 10.1158/1538-7445.AM2016-2614
   Schwiertz A, 2010, OBESITY, V18, P190, DOI 10.1038/oby.2009.167
   Shang WT, 2017, J FUNCT FOODS, V38, P20, DOI 10.1016/j.jff.2017.08.032
   Sharma P, 2017, INDIAN J CLIN BIOCHE, V32, P371, DOI 10.1007/s12291-017-0699-5
   Shimotoyodome A, 2010, AM J PHYSIOL-ENDOC M, V298, pE652, DOI 10.1152/ajpendo.00468.2009
   Si X, 2017, FOOD FUNCT, V8, P232, DOI 10.1039/c6fo01225f
   Si X, 2017, CARBOHYD POLYM, V157, P834, DOI 10.1016/j.carbpol.2016.10.042
   Takaishi K, 2004, P NATL ACAD SCI USA, V101, P7106, DOI 10.1073/pnas.0401715101
   Tan L, 2006, CHIN J CHROMATOGR, V24, P81
   Unwin N, 2010, DIABETES RES CLIN PR, V87, P2, DOI 10.1016/j.diabres.2009.11.006
   Van Gaal LF, 2006, NATURE, V444, P875, DOI 10.1038/nature05487
   Vital M, 2018, APPL ENVIRON MICROB, V84, DOI 10.1128/AEM.01562-18
   Wall CE, 2016, J MOL ENDOCRINOL, V57, pR49, DOI 10.1530/JME-16-0073
   Wolfenden Luke, 2016, Cochrane Database Syst Rev, V10, pCD011779
   Zhang L, 2019, BIOCHEM PHARMACOL, V164, P368, DOI 10.1016/j.bcp.2019.05.002
NR 51
TC 22
Z9 23
U1 0
U2 31
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD DEC 1
PY 2019
VL 10
IS 12
BP 7940
EP 7951
DI 10.1039/c9fo01771b
PG 12
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA KD1PE
UT WOS:000507643700028
PM 31777896
DA 2025-06-11
ER

PT J
AU Talari, HR
   Rafiee, M
   Farrokhian, A
   Raygan, F
   Bahmani, F
   Mofrad, MD
   Hamidian, Y
   Tamtaji, OR
   Karamali, F
   Asemi, Z
AF Talari, Hamid Reza
   Rafiee, Motahereh
   Farrokhian, Alireza
   Raygan, Fariba
   Bahmani, Fereshteh
   Mofrad, Manijeh Darooghegi
   Hamidian, Yaser
   Tamtaji, Omid Reza
   Karamali, Fatemeh
   Asemi, Zatollah
TI The Effects of Folate Supplementation on Carotid Intima-Media Thickness
   and Metabolic Status in Patients with Metabolic Syndrome
SO ANNALS OF NUTRITION AND METABOLISM
LA English
DT Article
DE Folate; Supplementation; Carotid intima-media thickness; Metabolic
   status; Metabolic syndrome
ID FOLIC-ACID SUPPLEMENTATION; POLYCYSTIC-OVARY-SYNDROME;
   CORONARY-HEART-DISEASE; B-GROUP-VITAMINS; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; CARDIOVASCULAR-DISEASE; ENDOTHELIAL FUNCTION; PLASMA
   HOMOCYSTEINE; ARTERIAL STIFFNESS
AB Background: This study was carried out to evaluate the effects of folate supplementation on carotid intima-media thickness (CIMT) and metabolic status among patients with metabolic syndrome (MetS). Methods: This randomized, double-blind, placebo-controlled trial was conducted among 60 patients with type 2 diabetes mellitus and coronary heart disease. They were all overweight in the age range 40-85 years. Participants were randomly divided into 2 groups: group A (n = 30) received 5 mg folate supplements and group B (n = 30) received placebo for 12 weeks. Results: Folate supplementation resulted in a significant reduction in maximum levels of left CIMT (-0.05 +/- 0.13 vs. +0.02 +/- 0.11 mm, p = 0.01) compared with the placebo. Changes in fasting plasma glucose (-2.2 +/- 37.5 vs. +30.2 +/- 65.8 mg/dl, p = 0.02), serum insulin concentration (-2.0 +/- 10.7 vs. +3.0 +/- 7.6 p = 0.04) and homeostasis of assessment-estimated insulin resistance (-0.6 +/- 2.3 vs. +0.9 +/- 2.3, p = 0.01) in supplemented patients were significantly different from those of patients in the placebo group. Changes in serum triglycerides (p = 0.04), high-density lipoprotein-cholesterol (p = 0.001), high sensitivity C-reactive protein (p = 0.01) and plasma nitric oxide concentrations (p < 0.001) were significantly different between the supplemented patients and placebo group. Conclusions: Overall, 5 mg/day folate supplementation for 12 weeks among patients with MetS had beneficial effects on CIMT and the metabolic status. (C) 2016 S. Karger AG, Basel.
C1 [Talari, Hamid Reza; Rafiee, Motahereh; Hamidian, Yaser] Kashan Univ Med Sci, Dept Radiol, Kashan, Iran.
   [Farrokhian, Alireza; Raygan, Fariba] Kashan Univ Med Sci, Sch Med, Dept Cardiol, Kashan, Iran.
   [Bahmani, Fereshteh; Mofrad, Manijeh Darooghegi; Asemi, Zatollah] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
   [Tamtaji, Omid Reza] Kashan Univ Med Sci, Physiol Res Ctr, Kashan, Iran.
   [Karamali, Fatemeh] Iran Univ Med Sci, Rajaie Cardiovasc Med & Res Ctr, Tehran, Iran.
C3 Iran University of Medical Sciences
RP Asemi, Z (corresponding author), Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
EM asemi_r@yahoo.com
RI Raygan, Fariba/GYU-8723-2022; asemi, zatollah/J-2677-2018; tamtaji,
   M/KWU-3655-2024; Farrokhian, Alireza/G-8864-2017; Asemi,
   Zatollah/G-7393-2017; Talari, Hamidreza/H-7838-2017; Bahmani,
   Fereshteh/G-7641-2017
OI Farrokhian, Alireza/0000-0002-7814-5539; Asemi,
   Zatollah/0000-0001-5265-4792; Talari, Hamidreza/0000-0001-6736-8449;
   Bahmani, Fereshteh/0000-0003-0683-3153; Tamtaji, Omid
   Reza/0000-0003-2492-3996; Raygan, Fariba/0000-0003-3789-5584
FU KUMS
FX This study was supported by a grant from the Vice-chancellor for
   Research, KUMS, and Iran.
CR Ainsworth BE, 2000, MED SCI SPORT EXER, V32, pS498, DOI 10.1097/00005768-200009001-00009
   Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
   Asemi Z, 2014, MOL NUTR FOOD RES, V58, P1465, DOI 10.1002/mnfr.201400033
   Austen SK, 2006, CLIN NEPHROL, V66, P373
   Bahmani F, 2014, CLIN ENDOCRINOL, V81, P582, DOI 10.1111/cen.12451
   Benzie IFF, 1996, ANAL BIOCHEM, V239, P70, DOI 10.1006/abio.1996.0292
   BEUTLER E, 1985, J LAB CLIN MED, V105, P581
   Bots ML, 1997, J CLIN EPIDEMIOL, V50, P801, DOI 10.1016/S0895-4356(97)00059-0
   Bouchi R, 2011, DIABETES CARE, V34, P2570, DOI 10.2337/dc11-1020
   Buettner R, 2010, HORM METAB RES, V42, P769, DOI 10.1055/s-0030-1263122
   Clarke R, 2002, JAMA-J AM MED ASSOC, V288, P2015, DOI 10.1001/jama.288.16.2015
   Durga J, 2011, AM J CLIN NUTR, V93, P941, DOI 10.3945/ajcn.110.006429
   Ford ES, 2002, INT J EPIDEMIOL, V31, P59, DOI 10.1093/ije/31.1.59
   JANERO DR, 1990, FREE RADICAL BIO MED, V9, P515, DOI 10.1016/0891-5849(90)90131-2
   Kawasaki R, 2011, OPHTHALMOLOGY, V118, P860, DOI 10.1016/j.ophtha.2010.08.040
   Kazerooni T, 2008, INT J GYNECOL OBSTET, V101, P156, DOI 10.1016/j.ijgo.2007.10.024
   Kelemen LE, 2004, ATHEROSCLEROSIS, V176, P361, DOI 10.1016/j.atherosclerosis.2004.06.003
   Kim CS, 2015, J DIABETES COMPLICAT, V29, P1085, DOI 10.1016/j.jdiacomp.2015.06.007
   Klein R, 2002, OPHTHALMOLOGY, V109, P1225, DOI 10.1016/S0161-6420(02)01074-6
   Lachin JM, 2016, CLIN TRIALS, V13, P161, DOI 10.1177/1740774515602688
   Liu CS, 2007, EUR J CLIN NUTR, V61, P996, DOI 10.1038/sj.ejcn.1602606
   Marcucci R, 2003, TRANSPLANTATION, V75, P1551, DOI 10.1097/01.TP.0000058810.59825.58
   Mierzecki Artur, 2012, Postepy Hig Med Dosw (Online), V66, P696, DOI 10.5604/17322693.1014655
   Ntaios G, 2010, INT J CARDIOL, V143, P16, DOI 10.1016/j.ijcard.2009.01.023
   Papatheodorou L, 2007, ANTIOXID REDOX SIGN, V9, P1941, DOI 10.1089/ars.2007.1750
   Pisprasert V, 2013, DIABETES CARE, V36, P845, DOI 10.2337/dc12-0840
   Qin XH, 2012, ATHEROSCLEROSIS, V222, P307, DOI 10.1016/j.atherosclerosis.2011.12.007
   Rydén L, 2007, EUR HEART J, V28, P88, DOI [10.1093/eurheartj/ehm124, 10.1093/eurheartj/ehl260]
   Shah AS, 2015, J CLIN ENDOCR METAB, V100, P2751, DOI 10.1210/jc.2014-4562
   Shams M., 2009, Eastern Mediterranean Health Journal, V15, P1285
   Shirodaria C, 2007, CIRCULATION, V115, P2262, DOI 10.1161/CIRCULATIONAHA.106.679084
   Solini A, 2006, INT J OBESITY, V30, P1197, DOI 10.1038/sj.ijo.0803265
   Stephens JW, 2006, CLIN CHEM, V52, P446, DOI 10.1373/clinchem.2005.060194
   Tatsch E, 2011, CLIN BIOCHEM, V44, P348, DOI 10.1016/j.clinbiochem.2010.12.011
   Tenenbaum A, 2007, AM HEART J, V153, P559, DOI 10.1016/j.ahj.2007.01.008
   Till U, 2005, ATHEROSCLEROSIS, V181, P131, DOI 10.1016/j.atherosclerosis.2004.12.043
   Ullegaddi R, 2004, CLIN SCI, V107, P477, DOI 10.1042/CS20040134
   Ullegaddi R, 2006, JPEN-PARENTER ENTER, V30, P108, DOI 10.1177/0148607106030002108
   Verhaar MC, 1999, CIRCULATION, V100, P335, DOI 10.1161/01.CIR.100.4.335
   Villa P, 2005, J CLIN ENDOCR METAB, V90, P4622, DOI 10.1210/jc.2004-1954
   Welles CC, 2014, AM J EPIDEMIOL, V179, P1279, DOI 10.1093/aje/kwu059
   Wotherspoon F, 2008, INT J CLIN PRACT, V62, P569, DOI 10.1111/j.1742-1241.2007.01658.x
   Xie JJ, 2009, J ATHEROSCLER THROMB, V16, P641, DOI 10.5551/jat.1586
   Zhao GX, 2010, DIABETES CARE, V33, P344, DOI 10.2337/dc09-0924
NR 44
TC 27
Z9 27
U1 0
U2 6
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-6807
EI 1421-9697
J9 ANN NUTR METAB
JI Ann. Nutr. Metab.
PY 2016
VL 69
IS 1
BP 41
EP 50
DI 10.1159/000448295
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA DV8WB
UT WOS:000383216300006
PM 27450552
DA 2025-06-11
ER

PT J
AU Gomaraschi, M
   Ossoli, A
   Adorni, MP
   Damonte, E
   Niesor, E
   Veglia, F
   Franceschini, G
   Benghozi, R
   Calabresi, L
AF Gomaraschi, Monica
   Ossoli, Alice
   Adorni, Maria Pia
   Damonte, Elisabetta
   Niesor, Eric
   Veglia, Fabrizio
   Franceschini, Guido
   Benghozi, Renee
   Calabresi, Laura
TI Fenofibrate and extended-release niacin improve the endothelial
   protective effects of HDL in patients with metabolic syndrome
SO VASCULAR PHARMACOLOGY
LA English
DT Article
DE High density lipoprotein; Niacin; Fenofibrate; Endothelial cells; Nitric
   oxide
ID HIGH-DENSITY-LIPOPROTEIN; TYPE-2 DIABETES-MELLITUS; SCAVENGER
   RECEPTOR-BI; NITRIC-OXIDE SYNTHASE; CORONARY-HEART-DISEASE; COMBINED
   HYPERLIPIDEMIA; INFLAMMATORY MARKERS; VASCULAR REACTIVITY; CHOLESTEROL
   LEVELS; OXIDATIVE STRESS
AB Background: Fibrates and niacin are at present the most effective therapies to increase plasma levels of high density lipoprotein-cholesterol (HDL-C); to date, limited data are available on their effects on HDL protective functions.
   Methods and results: Within a multicenter, randomized, open-label, cross-over study, 37 patients with metabolic syndrome received 6 weeks' treatment with fenofibrate or extended-release niacin (ER niacin), with a 4 weeks' wash-out period. HDL ability to preserve endothelial cell homeostasis was assessed by incubating cultured endothelial cells with HDL isolated from patients at baseline and after each treatment. HDL isolated from patients at baseline were as effective as control HDL in inhibiting vascular cell adhesion molecule-1 (VCAM-1) expression, but less efficient in promoting endothelial cell nitric oxide (NO) release. Both fenofibrate and ER niacin increased HDL ability to inhibit TNF alpha-induced VCAM-1 expression (+7% and +11%, respectively). Fenofibrate and ER niacin also improved the impaired HDL ability to induce the expression of endothelial nitric oxide synthase and NO production (+10% and +8%, respectively). Interestingly. HDL isolated after treatment showed an ability to promote endothelial NO release similar to HDL isolated from controls. No differences were observed between the two drugs. With both drugs, HDL function was improved irrespective of baseline HDL-C levels.
   Conclusion: Treatment with fenofibrate or ER niacin in patients with metabolic syndrome not only increased HDL-C levels but also improved the endothelial protective effects of HDL. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Gomaraschi, Monica; Ossoli, Alice; Franceschini, Guido; Calabresi, Laura] Univ Milan, Dipartimento Sci Farmacol & Biomol, Ctr E Grossi Paoletti, I-20133 Milan, Italy.
   [Adorni, Maria Pia] Univ Parma, Dept Pharm, I-43100 Parma, Italy.
   [Damonte, Elisabetta; Niesor, Eric; Benghozi, Renee] F Hoffmann La Roche Ltd, Basel, Switzerland.
   [Veglia, Fabrizio] IRCCS Cardiol Monzino, Milan, Italy.
C3 University of Milan; University of Parma; Roche Holding
RP Calabresi, L (corresponding author), Univ Milan, Dept Pharmacol & Biomol Sci, Via Balzaretti 9, I-20133 Milan, Italy.
EM laura.calabresi@unimi.it
RI Adorni, Maria/C-9887-2012; Veglia, Fabrizio/K-1958-2016; Gomaraschi,
   Monica/A-3601-2014; Ossoli, Alice/K-5917-2016
OI Calabresi, Laura/0000-0001-5042-9532; Veglia,
   Fabrizio/0000-0002-9378-8874; Gomaraschi, Monica/0000-0003-3082-2120;
   Ossoli, Alice/0000-0002-9902-252X; FRANCESCHINI,
   GUIDO/0000-0003-2687-1771
FU F. Hoffmann-La Roche Ltd, Basel, Switzerland [BP20843]
FX The study was supported by F. Hoffmann-La Roche Ltd, Basel, Switzerland
   (BP20843).
CR Avogaro A, 2001, EUR J CLIN INVEST, V31, P603, DOI 10.1046/j.1365-2362.2001.00856.x
   Barter PJ, 2012, J LIPID RES, V53, P1755, DOI 10.1194/jlr.R024075
   Benjó AM, 2006, ATHEROSCLEROSIS, V187, P116, DOI 10.1016/j.atherosclerosis.2005.08.025
   Besler C, 2011, J CLIN INVEST, V121, P2693, DOI 10.1172/JCI42946
   Boden WE, 2011, NEW ENGL J MED, V365, P2255, DOI 10.1056/NEJMoa1107579
   Calabresi L, 2005, ARTERIOSCL THROM VAS, V25, P1972, DOI 10.1161/01.ATV.0000175751.30616.13
   Calabresi L, 2003, ARTERIOSCL THROM VAS, V23, P1724, DOI 10.1161/01.ATV.0000094961.74697.54
   Calabresi L, 2010, CURR PHARM DESIGN, V16, P1494, DOI 10.2174/138161210791050960
   Calabresi L, 2009, ATHEROSCLEROSIS, V205, P506, DOI 10.1016/j.atherosclerosis.2009.01.006
   Calabresi L, 2009, ATHEROSCLEROSIS, V204, P141, DOI 10.1016/j.atherosclerosis.2008.08.038
   Castelli W P, 1992, Ann Epidemiol, V2, P23, DOI 10.1016/1047-2797(92)90033-M
   Chapman MJ, 2010, PHARMACOL THERAPEUT, V126, P314, DOI 10.1016/j.pharmthera.2010.01.008
   Chapman MJ, 2005, CARDIOVASC DRUG THER, V19, P135, DOI 10.1007/s10557-005-1049-z
   COCKERILL GW, 1995, ARTERIOSCL THROM VAS, V15, P1987, DOI 10.1161/01.ATV.15.11.1987
   Cuchel M, 2006, CIRCULATION, V113, P2548, DOI 10.1161/CIRCULATIONAHA.104.475715
   de Beer MC, 2001, J BIOL CHEM, V276, P15832, DOI 10.1074/jbc.M100228200
   Degoma EM, 2008, J AM COLL CARDIOL, V51, P2199, DOI 10.1016/j.jacc.2008.03.016
   Demacker PNM, 2000, ATHEROSCLEROSIS, V153, P483, DOI 10.1016/S0021-9150(00)00432-9
   Di Angelantonio E, 2009, JAMA-J AM MED ASSOC, V302, P1993, DOI 10.1001/jama.2009.1619
   Evans M, 2000, CIRCULATION, V101, P1773, DOI 10.1161/01.CIR.101.15.1773
   Franceschini G, 2013, J CLIN LIPIDOL, V7, P414, DOI 10.1016/j.jacl.2013.06.007
   Ghani RA, 2013, J CLIN LIPIDOL, V7, P446, DOI 10.1016/j.jacl.2013.04.004
   Ginsberg HN, 2010, NEW ENGL J MED, V362, P1563, DOI 10.1056/NEJMoa1001282
   Gomaraschi M, 2007, CIRCULATION, V116, P2165, DOI 10.1161/CIRCULATIONAHA.107.705657
   Gomaraschi M, 2015, HANDB EXP PHARMACOL, V224, P593, DOI 10.1007/978-3-319-09665-0_19
   Gomaraschi M, 2013, CARDIOVASC RES, V100, P36, DOI 10.1093/cvr/cvt169
   GRIZZLE JE, 1965, BIOMETRICS, V21, P467, DOI 10.2307/2528104
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Haynes R, 2013, EUR HEART J, V34, P1279, DOI 10.1093/eurheartj/eht055
   Higashi Y, 2010, AM J PHYSIOL-ENDOC M, V298, pE202, DOI 10.1152/ajpendo.00394.2009
   Igarashi J, 2007, BRIT J PHARMACOL, V150, P470, DOI 10.1038/sj.bjp.0707114
   Keech A, 2005, LANCET, V366, P1849, DOI 10.1016/S0140-6736(05)67667-2
   Kimura T, 2008, J IMMUNOL, V181, P7332, DOI 10.4049/jimmunol.181.10.7332
   Kuvin JT, 2002, AM HEART J, V144, P165, DOI 10.1067/mhj.2002.123145
   Malik J, 2001, CARDIOVASC RES, V52, P290, DOI 10.1016/S0008-6363(01)00382-0
   Martinelli N, 2012, EXP DIABETES RES, DOI 10.1155/2012/231502
   Masana L, 2015, ATHEROSCLEROSIS, V238, P213, DOI 10.1016/j.atherosclerosis.2014.12.006
   Mineo C, 2003, J BIOL CHEM, V278, P9142, DOI 10.1074/jbc.M211394200
   Mineo C, 2006, CIRC RES, V98, P1352, DOI 10.1161/01.RES.0000225982.01988.93
   MURAKAMI T, 1995, ARTERIOSCL THROM VAS, V15, P1819, DOI 10.1161/01.ATV.15.11.1819
   Nofer JR, 2004, J CLIN INVEST, V113, P569, DOI 10.1172/JCI200418004
   OTVOS JD, 1992, CLIN CHEM, V38, P1632
   Paragh G, 2003, DIABETES METAB, V29, P613, DOI 10.1016/S1262-3636(07)70077-0
   Phuntuwate W, 2008, ATHEROSCLEROSIS, V196, P122, DOI 10.1016/j.atherosclerosis.2007.03.001
   Reriani MK, 2011, EUR J CARDIOV PREV R, V18, P704, DOI 10.1177/1741826711398430
   Rinninger F, 2003, ATHEROSCLEROSIS, V166, P31, DOI 10.1016/S0021-9150(02)00311-8
   Sorrentino SA, 2010, CIRCULATION, V121, P110, DOI 10.1161/CIRCULATIONAHA.108.836346
   Speer T, 2013, IMMUNITY, V38, P754, DOI 10.1016/j.immuni.2013.02.009
   Thoenes M, 2007, INT J CLIN PRACT, V61, P1942, DOI 10.1111/j.1742-1241.2007.01597.x
   Wang TD, 2003, ATHEROSCLEROSIS, V170, P315, DOI 10.1016/S0021-9150(03)00296-X
   Yesilbursa Dilek, 2005, Kardiol Pol, V62, P526
   Yuhanna IS, 2001, NAT MED, V7, P853, DOI 10.1038/89986
NR 52
TC 11
Z9 11
U1 1
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1537-1891
EI 1879-3649
J9 VASC PHARMACOL
JI Vasc. Pharmacol.
PD NOV
PY 2015
VL 74
BP 80
EP 86
DI 10.1016/j.vph.2015.06.014
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CY1DE
UT WOS:000366146100008
PM 26133666
DA 2025-06-11
ER

PT J
AU Yao, JM
   Zhao, Y
   Zhang, JW
   Hong, YN
   Lu, HL
   Wu, JP
AF Yao, Jinmei
   Zhao, Ying
   Zhang, Juanwen
   Hong, Yani
   Lu, Huanle
   Wu, Jianping
TI Serum amylase levels are decreased in Chinese non-alcoholic fatty liver
   disease patients
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE NAFLD; Amylase; Metabolic syndrome; Fibrosis
ID ENDOPLASMIC-RETICULUM STRESS; HEPATIC INSULIN-RESISTANCE; METABOLIC
   SYNDROME; RISK-FACTORS; DIABETES-MELLITUS; NATURAL-HISTORY;
   STEATOHEPATITIS; ASSOCIATION; POPULATION; STEATOSIS
AB Background: Low serum amylase levels have been reported in patients with metabolic syndrome (MS), diabetes, and asymptomatic non-alcoholic fatty liver disease (NAFLD). However, no study has yet indicated the serum amylase levels in NAFLD with MS. The aim of the present study was to evaluate serum amylase levels in NAFLD patients with and without MS, and to explore a possible association between serum amylase levels with the components of MS and the degree of hepatic fibrosis in NAFLD patients.
   Methods: Our study included 713 NAFLD participants (180 females and 533 males) and 304 healthy control participants (110 females and 194 males). The diagnosis of NAFLD was based on ultrasonography, and advanced fibrosis was assessed by the FIB-4 index.
   Results: Serum amylase levels were significantly lower in NAFLD patients with MS compared with NAFLD patients without MS and healthy controls (42, 45, and 53 IU/L, respectively). The serum amylase levels of patients with elevated glucose, elevated triglycerides, and low high density lipoprotein cholesterol patients were significantly lower than in case of normal parameters (both p < 0.05). Multivariate logistic regression analysis showed that a relative serum amylase level increase was an independent factor predicting advanced fibrosis (FIB-4 = 1.3) in NAFLD participants (OR: 1.840, 95% CI: 1.117-3.030, p = 0.017).
   Conclusions: Compared with NAFLD patients without MS and healthy controls, serum amylase levels were significantly lower in NAFLD patients with MS. Moreover, a relative serum amylase increase may be an independent factor of more advanced hepatic fibrosis.
C1 [Yao, Jinmei; Zhao, Ying; Zhang, Juanwen; Hong, Yani; Lu, Huanle; Wu, Jianping] Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Lab Med, Hangzhou 310003, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Zhang, JW (corresponding author), Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Lab Med, 79 QingChun Rd, Hangzhou 310003, Zhejiang, Peoples R China.
EM tym2011@yeah.net
RI Wu, Jianping/H-9150-2012
FU Department of Education Foundation of Zhejiang Province, China
   [Y201330146]; Science Foundation of the Health Bureau of Zhejiang
   Province [2013KYB116]; National Natural Science Foundation of China
   [81370008]
FX This work was financially supported by grants from the Department of
   Education Foundation of Zhejiang Province, China (No. Y201330146), the
   Science Foundation of the Health Bureau of Zhejiang Province (No.
   2013KYB116), and the National Natural Science Foundation of China (No.
   81370008).
CR Adams LA, 2011, J GASTROEN HEPATOL, V26, P1536, DOI 10.1111/j.1440-1746.2011.06774.x
   Aughsteen AA, 2005, SAUDI MED J, V26, P73
   Baffy G, 2009, J HEPATOL, V51, P212, DOI 10.1016/j.jhep.2009.03.008
   Blachier M, 2013, J HEPATOL, V58, P593, DOI 10.1016/j.jhep.2012.12.005
   Bugianesi E, 2002, GASTROENTEROLOGY, V123, P134, DOI 10.1053/gast.2002.34168
   Chalasani N, 2012, HEPATOLOGY, V55, P2005, DOI 10.1002/hep.25762
   Chan SMH, 2013, DIABETES, V62, P2095, DOI 10.2337/db12-1397
   Chen BD, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0068780
   Choi CS, 2007, J BIOL CHEM, V282, P22678, DOI 10.1074/jbc.M704213200
   DANDONA P, 1984, J CLIN PATHOL, V37, P302, DOI 10.1136/jcp.37.3.302
   Demir M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0058360
   DOMINGUEZMUNOZ JE, 1993, DIGESTION, V54, P231
   Fan JG, 2005, J HEPATOL, V43, P508, DOI 10.1016/j.jhep.2005.02.042
   Fan JG, 2007, J GASTROEN HEPATOL, V22, P794, DOI 10.1111/j.1440-1746.2007.04952.x
   Gruben N, 2014, BBA-MOL BASIS DIS, V1842, P2329, DOI 10.1016/j.bbadis.2014.08.004
   Hurjui DM, 2012, MED-SURG J, V116, P425
   Jian-gao Fan, 2010, Zhonghua Gan Zang Bing Za Zhi, V18, P163
   Jornayvaz FR, 2012, CELL METAB, V15, P574, DOI 10.1016/j.cmet.2012.03.005
   Kharroubi I, 2004, ENDOCRINOLOGY, V145, P5087, DOI 10.1210/en.2004-0478
   Kim HM, 2013, CLIN MOL HEPATOL, V19, P258, DOI 10.3350/cmh.2013.19.3.258
   Klover PJ, 2004, INT J BIOCHEM CELL B, V36, P753, DOI 10.1016/j.biocel.2003.10.002
   Lann D, 2007, MED CLIN N AM, V91, P1063, DOI 10.1016/j.mcna.2007.06.012
   Lee JG, 2011, CLIN CHIM ACTA, V412, P1848, DOI 10.1016/j.cca.2011.06.023
   Liang W, 2014, LAB INVEST, V94, P491, DOI 10.1038/labinvest.2014.11
   Lonardo A, 2013, CURR PHARM DESIGN, V19, P5177, DOI 10.2174/1381612811319290003
   Maruyama K, 2003, ALCOHOL CLIN EXP RES, V27, p16S, DOI 10.1097/01.ALC.0000078827.46112.76
   Muneyuki T, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-80
   Nakajima K, 2013, BMJ OPEN, V3, DOI 10.1136/bmjopen-2012-002235
   Nakajima Kei, 2011, BMC Res Notes, V4, P419, DOI 10.1186/1756-0500-4-419
   Nakajima K, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-34
   Nascimbeni F, 2013, J HEPATOL, V59, P859, DOI 10.1016/j.jhep.2013.05.044
   Olson DE, 2010, DIABETES CARE, V33, P2184, DOI 10.2337/dc10-0433
   Patel NS, 2013, ALIMENT PHARM THER, V37, P630, DOI 10.1111/apt.12237
   Pitt Henry A, 2007, HPB (Oxford), V9, P92, DOI 10.1080/13651820701286177
   Seki E, 2012, GASTROENTEROLOGY, V143, P307, DOI 10.1053/j.gastro.2012.06.004
   Sepe PS, 2011, GASTROINTEST ENDOSC, V73, P987, DOI 10.1016/j.gie.2011.01.015
   Sumida Y, 2014, WORLD J GASTROENTERO, V20, P475, DOI 10.3748/wjg.v20.i2.475
   Sun XX, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-1045
   Utzschneider KM, 2006, J CLIN ENDOCR METAB, V91, P4753, DOI 10.1210/jc.2006-0587
   van Geenen EJM, 2010, PANCREAS, V39, P1185, DOI 10.1097/MPA.0b013e3181f6fce2
   Vernon G, 2011, ALIMENT PHARM THER, V34, P274, DOI 10.1111/j.1365-2036.2011.04724.x
   Wang Lan, 2008, Zhonghua Gan Zang Bing Za Zhi, V16, P870
   Weiss J, 2014, DTSCH ARZTEBL INT, V111, P447, DOI 10.3238/arztebl.2014.0447
   Wong VWS, 2004, ALIMENT PHARM THER, V20, P45, DOI 10.1111/j.1365-2036.2004.02012.x
   Wu BU, 2013, GASTROENTEROLOGY, V144, P1272, DOI 10.1053/j.gastro.2013.01.075
   Wu WC, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-77
   Xun YH, 2012, J DIGEST DIS, V13, P588, DOI 10.1111/j.1751-2980.2012.00631.x
   Yang Rong-Wei, 2005, Hepatobiliary Pancreat Dis Int, V4, P600
   Zeng MD, 2008, J DIGEST DIS, V9, P108, DOI 10.1111/j.1751-2980.2008.00331.x
   Zhang JW, 2014, SCI REP-UK, V4, DOI 10.1038/srep05832
   Zhang XL, 2008, PANCREAS, V37, pE31, DOI 10.1097/MPA.0b013e3181744b50
   Zhao Y, 2014, SCAND J CLIN LAB INV, V74, P235, DOI 10.3109/00365513.2013.878469
   Zhou YJ, 2007, WORLD J GASTROENTERO, V13, P6419, DOI 10.3748/wjg.13.6419
NR 53
TC 12
Z9 13
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD DEC 7
PY 2014
VL 13
AR 185
DI 10.1186/1476-511X-13-185
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA AX5BP
UT WOS:000346942500001
PM 25481429
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Harrell, JW
   Schrage, WG
AF Harrell, John W.
   Schrage, William G.
TI Cyclooxygenase-derived vasoconstriction restrains hypoxia-mediated
   cerebral vasodilation in young adults with metabolic syndrome
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE metabolic syndrome; cerebral blood flow; cyclooxygenase
ID BRAIN BLOOD-FLOW; OXIDATIVE STRESS; BREATHING STABILITY; NORTHERN
   MANHATTAN; STROKE; RISK; RATS; ARTERIES; ATHEROSCLEROSIS; INDOMETHACIN
AB Poor cerebrovascular function in metabolic syndrome (MetSyn) likely contributes to elevated risk of cerebrovascular disease in this growing clinical population. Younger MetSyn adults without clinical evidence of cerebrovascular disease exhibit preserved hypercapnic vasodilation yet markedly impaired hypoxic vasodilation, but the mechanisms behind reduced hypoxic vasodilation are unknown. Based on data from rats, we tested the hypothesis that younger adults with MetSyn exhibit reduced cerebral hypoxic vasodilation due to loss of vasodilating prostaglandins. Middle cerebral artery velocity (MCAv) was measured with transcranial Doppler ultrasound in adults with MetSyn (n = 13, 33 +/- 3 yr) and healthy controls (n = 15, 31 +/- 2 yr). Isocapnic hypoxia was induced by titrating inspired oxygen to lower arterial saturation to 90% and 80% for 5 min each. Separately, hypercapnia was induced by increasing end-tidal CO2 10 mmHg above baseline levels. Cyclooxygenase inhibition (100 mg indomethacin) was conducted in a randomized double-blind, placebo controlled design. MCAv was normalized for group differences in blood pressure (healthy: 89 +/- 2 mmHg vs. MetSyn: 102 +/- 2 mmHg) as cerebrovascular conductance index (CVCi), and used to assess cerebral vasodilation. Hypoxia increased CVCi in both groups; however, vasodilation was similar to 55% lower in MetSyn at SpO(2) = 80% (P < 0.05). Indomethacin tended to decrease hypoxic vasodilation in healthy controls, and unexpectedly increased dilation in MetSyn (P < 0.05). In contrast to hypoxia, hypercapnia-mediated vasodilation was similar between groups, as was the decrease in vasodilation with indomethacin. These data indicate increased production of vasoconstrictor prostaglandins restrains hypoxic cerebral vasodilation in MetSyn, preventing them from responding appropriately to this important physiological stressor.
C1 [Harrell, John W.; Schrage, William G.] Univ Wisconsin, Dept Kinesiol, Bruno Balke Biodynam Lab, Madison, WI 53706 USA.
C3 University of Wisconsin System; University of Wisconsin Madison
RP Schrage, WG (corresponding author), Univ Wisconsin, Dept Kinesiol, 1149A Natatorium, Madison, WI 53706 USA.
EM wschrage@education.wisc.edu
FU American Heart Association [11PRE7390038]; National Institutes of Health
   [HL-105820]; University of Wisconsin School of Medicine and Public
   Health Shapiro Summer Research Program; American Heart Association (AHA)
   [11PRE7390038] Funding Source: American Heart Association (AHA)
FX Funding for this project was provided by the American Heart Association
   (11PRE7390038, J. W. Harrell), National Institutes of Health (HL-105820,
   W. G. Schrage), and the University of Wisconsin School of Medicine and
   Public Health Shapiro Summer Research Program.
CR Barnes JN, 2012, J APPL PHYSIOL, V112, P1884, DOI 10.1152/japplphysiol.01270.2011
   Boden-Albala B, 2008, STROKE, V39, P30, DOI 10.1161/STROKEAHA.107.496588
   COYLE MG, 1995, AM J PHYSIOL-HEART C, V269, pH1450, DOI 10.1152/ajpheart.1995.269.4.H1450
   Di Carlo A, 2009, AGE AGEING, V38, P4, DOI 10.1093/ageing/afn282
   Erdös B, 2002, AM J PHYSIOL-HEART C, V282, pH2060, DOI 10.1152/ajpheart.01124.2001
   Fan JL, 2011, EUR J APPL PHYSIOL, V111, P601, DOI 10.1007/s00421-010-1679-0
   Fan JL, 2010, AM J PHYSIOL-REG I, V298, pR1648, DOI 10.1152/ajpregu.00721.2009
   Félétou M, 2011, BRIT J PHARMACOL, V164, P894, DOI 10.1111/j.1476-5381.2011.01276.x
   Félétou M, 2010, ADV PHARMACOL, V60, P85, DOI [10.1016/S1054-3589(10)60006-3, 10.1016/B978-0-12-385061-4.00004-0]
   FREDRICKS KT, 1994, AM J PHYSIOL, V267, pH580, DOI 10.1152/ajpheart.1994.267.2.H580
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Giannopoulos S, 2010, EUR J NEUROL, V17, P1457, DOI 10.1111/j.1468-1331.2010.03087.x
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hachinski V, 2006, STROKE, V37, P2220, DOI 10.1161/01.STR.0000237236.88823.47
   Harrell JW, 2013, DIABETES VASC DIS RE, V10, P135, DOI 10.1177/1479164112448875
   Katakam PVG, 2009, AM J PHYSIOL-REG I, V296, pR289, DOI 10.1152/ajpregu.90656.2008
   Kurl S, 2006, STROKE, V37, P806, DOI 10.1161/01.STR.0000204354.06965.44
   Limberg JK, 2013, AM J PHYSIOL-HEART C, V305, pH1230, DOI 10.1152/ajpheart.00291.2013
   Marshall RS, 2003, STROKE, V34, P945, DOI 10.1161/01.STR.0000062351.66804.1C
   McSwain SD, 2010, RESP CARE, V55, P288
   Panza F, 2010, J ALZHEIMERS DIS, V21, P691, DOI 10.3233/JAD-2010-091669
   Phillips SA, 2005, AM J PHYSIOL-REG I, V288, pR522, DOI 10.1152/ajpregu.00655.2004
   Poulin MJ, 1996, STROKE, V27, P2244, DOI 10.1161/01.STR.27.12.2244
   Reichmuth KJ, 2009, AM J RESP CRIT CARE, V180, P1143, DOI 10.1164/rccm.200903-0393OC
   Rodriguez-Colon SM, 2009, STROKE, V40, P200, DOI 10.1161/STROKEAHA.108.523035
   Silvestrini M, 2000, JAMA-J AM MED ASSOC, V283, P2122, DOI 10.1001/jama.283.16.2122
   TADDEI S, 1993, HYPERTENSION, V21, P929, DOI 10.1161/01.HYP.21.6.929
   Tomiyama Y, 1999, STROKE, V30, P1942, DOI 10.1161/01.STR.30.9.1942
   Van Guilder GP, 2006, OBESITY, V14, P2127, DOI 10.1038/oby.2006.248
   Vieira JR, 2011, NEUROEPIDEMIOLOGY, V37, P153, DOI 10.1159/000332208
   Wannamethee SG, 2005, ARCH INTERN MED, V165, P2644, DOI 10.1001/archinte.165.22.2644
   Willie CK, 2012, J PHYSIOL-LONDON, V590, P3261, DOI 10.1113/jphysiol.2012.228551
   Wilson MH, 2011, J CEREBR BLOOD F MET, V31, P2019, DOI 10.1038/jcbfm.2011.81
   Xie AL, 2006, J PHYSIOL-LONDON, V577, P319, DOI 10.1113/jphysiol.2006.110627
   Xie AL, 2009, J APPL PHYSIOL, V106, P850, DOI 10.1152/japplphysiol.90914.2008
NR 35
TC 13
Z9 16
U1 0
U2 2
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD JAN
PY 2014
VL 306
IS 2
BP H261
EP H269
DI 10.1152/ajpheart.00709.2013
PG 9
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 293PG
UT WOS:000329984300012
PM 24213610
OA Green Published
DA 2025-06-11
ER

PT J
AU Durak, A
   Olgar, Y
   Degirmenci, S
   Akkus, E
   Tuncay, E
   Turan, B
AF Durak, Aysegul
   Olgar, Yusuf
   Degirmenci, Sinan
   Akkus, Erman
   Tuncay, Erkan
   Turan, Belma
TI A SGLT2 inhibitor dapagliflozin suppresses prolonged
   ventricular-repolarization through augmentation of mitochondrial
   function in insulin-resistant metabolic syndrome rats
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Diabetes; SGLT2 inhibitors; Heart function; Electrophysiology; Oxidative
   stress; Insulin resistance
ID OXIDATIVE STRESS; NA+/H+ EXCHANGER; DYSFUNCTION; HEART; EMPAGLIFLOZIN;
   OBESITY; CARDIOMYOCYTES; MORTALITY; ZN2+; PATHOPHYSIOLOGY
AB Background: Metabolic syndrome (MetS) is a prevalent risk factor for cardiac dysfunction. Although SGLT2-inhibitors have important cardioprotective effects in hyperglycemia, their underlying mechanisms are complex and not completely understood. Therefore, we examined mechanisms of a SGLT2-inhibitor dapagliflozin (DAPA)-related cardioprotection in overweight insulin-resistant MetS-rats comparison with insulin (INSU), behind its glucose-lowering effect.
   Methods: A 28-week high-carbohydrate diet-induced MetS-rats received DAPA (5 mg/kg), INSU (0.15 mg/kg) or vehicle for 2 weeks. To validate MetS-induction, we monitored all animals weekly by measuring body weight, blood glucose and HOMO-IR index, electrocardiograms, heart rate, systolic and diastolic pressures.
   Results: DAPA-treatment of MetS-rats significantly augmented the increased blood pressure, prolonged Q-R interval, and low heart rate with depressed left ventricular function and relaxation of the aorta. Prolonged-action potentials were preserved with DAPA-treatment, more prominently than INSU-treatment, at most, through the augmentation in depressed voltage-gated K+-channel currents. DAPA, more prominently than INSU-treatment, preserved the depolarized mitochondrial membrane potential, and altered mitochondrial protein levels such as Mfn-1, Mfn-2, and Fis-1 as well as provided significant augmentation in cytosolic Ca2+-homeostasis. Furthermore, DAPA also induced significant augmentation in voltage-gated Na+-currents and intracellular pH, and the cellular levels of increased oxidative stress, protein-thiol oxidation and ADP/ATP ratio in cardiomyocytes from MetS rats. Moreover, DAPA-treatment normalized the increases in the mRNA level of SGLT2 in MetS-rat heart.
   Conclusions: Overall, our data provided a new insight into DAPA-associated cardioprotection in MetS rats, including suppression of prolonged ventricular-repolarization through augmentation of mitochondrial function and oxidative stress followed by improvement of fusion-fission proteins, out of its glucose-lowering effect.
C1 [Durak, Aysegul; Olgar, Yusuf; Degirmenci, Sinan; Tuncay, Erkan; Turan, Belma] Ankara Univ, Dept Biophys, Fac Med, Ankara, Turkey.
   [Akkus, Erman] Ankara Univ, Fac Med, Internal Med, Ankara, Turkey.
C3 Ankara University; Ankara University
RP Turan, B (corresponding author), Ankara Univ, Dept Biophys, Fac Med, Ankara, Turkey.
EM belma.turan@medicine.ankara.edu.tr
RI olğar, yusuf/I-8960-2016; durak, aysegul/AAA-7647-2022; TUNCAY,
   ERKAN/AAG-8065-2020; TURAN, Belma/AAG-8084-2020; Akkus,
   Erman/ADT-1337-2022; Değirmenci, Sinan/M-7694-2013
OI TUNCAY, ERKAN/0000-0002-6675-2534; TURAN, Belma/0000-0003-2583-9294;
   OLGAR, YUSUF/0000-0002-3226-7450
FU TUBITAK [SBAG-214S254]
FX This study was supported by TUBITAK SBAG-214S254 to BT.
CR Aguilar D, 2009, J AM COLL CARDIOL, V54, P422, DOI 10.1016/j.jacc.2009.04.049
   Alpert MA, 2001, AM J MED SCI, V321, P225, DOI 10.1097/00000441-200104000-00003
   Anderson EJ, 2009, J CLIN INVEST, V119, P573, DOI 10.1172/JCI37048
   Ayaz M, 2004, ARCH BIOCHEM BIOPHYS, V426, P83, DOI 10.1016/j.abb.2004.03.030
   Baartscheer A, 2017, DIABETOLOGIA, V60, P568, DOI 10.1007/s00125-016-4134-x
   Bilginoglu A, 2013, CARDIOVASC TOXICOL, V13, P138, DOI 10.1007/s12012-012-9192-9
   Billur D, 2016, BIOL TRACE ELEM RES, V174, P177, DOI 10.1007/s12011-016-0704-5
   Degirmenci S, 2018, J TRACE ELEM MED BIO, V48, P202, DOI 10.1016/j.jtemb.2018.04.014
   DESIMONE G, 1994, HYPERTENSION, V23, P600, DOI 10.1161/01.HYP.23.5.600
   Durak A, 2017, CAN J PHYSIOL PHARM, V95, P1335, DOI 10.1139/cjpp-2017-0054
   Faria A, 2017, PHARMACOL THERAPEUT, V172, P50, DOI 10.1016/j.pharmthera.2016.11.013
   Galloway CA, 2015, ANTIOXID REDOX SIGN, V22, P1545, DOI 10.1089/ars.2015.6293
   Gottdiener JS, 1997, J AM COLL CARDIOL, V29, P651, DOI 10.1016/S0735-1097(96)00554-2
   Habibi J, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-016-0489-z
   Hammoudi N, 2017, CARDIOVASC DRUG THER, V31, P233, DOI 10.1007/s10557-017-6734-1
   Han SP, 2008, DIABETES, V57, P1723, DOI 10.2337/db07-1472
   Hernández-Reséndiz S, 2013, CURR DRUG TARGETS, V14, P586, DOI 10.2174/1389450111314050008
   Ilkun O, 2013, CURR PHARM DESIGN, V19, P4806, DOI 10.2174/1381612811319270003
   Joubert M, 2017, DIABETES, V66, P1030, DOI 10.2337/db16-0733
   Kelley DE, 2002, DIABETES, V51, P2944, DOI 10.2337/diabetes.51.10.2944
   Khalaf KI, 2012, TEX HEART I J, V39, P174
   Kiselyov K, 2016, CELL CALCIUM, V60, P108, DOI 10.1016/j.ceca.2016.03.004
   KREGE JH, 1995, HYPERTENSION, V25, P1111, DOI 10.1161/01.HYP.25.5.1111
   Kusaka H, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-016-0473-7
   Lahnwong S, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0745-5
   Lambert R, 2015, J AM HEART ASSOC, V4, DOI 10.1161/JAHA.115.002183
   LAUER MS, 1992, J AM COLL CARDIOL, V19, P130, DOI 10.1016/0735-1097(92)90063-S
   Lee TM, 2017, FREE RADICAL BIO MED, V104, P298, DOI 10.1016/j.freeradbiomed.2017.01.035
   Litvinova L, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00020
   Mitchell T, 2012, FREE RADICAL BIO MED, V52, P838, DOI 10.1016/j.freeradbiomed.2011.12.014
   Montaigne D, 2014, CIRCULATION, V130, P554, DOI 10.1161/CIRCULATIONAHA.113.008476
   Mustroph J, 2018, ESC HEART FAIL, V5, P642, DOI 10.1002/ehf2.12336
   Okatan EN, 2015, CAN J PHYSIOL PHARM, V93, P517, DOI 10.1139/cjpp-2014-0507
   Olgar Y, 2018, EXP GERONTOL, V110, P172, DOI 10.1016/j.exger.2018.06.012
   Ott C, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-017-0510-1
   Packer M, 2017, CIRCULATION, V136, P1548, DOI 10.1161/CIRCULATIONAHA.117.030418
   Petersen KF, 2003, SCIENCE, V300, P1140, DOI 10.1126/science.1082889
   Pocock SJ, 2006, EUR HEART J, V27, P65, DOI 10.1093/eurheartj/ehi555
   Sa-Nguanmoo P, 2018, BIOMED PHARMACOTHER, V97, P1663, DOI 10.1016/j.biopha.2017.12.021
   Sebastián D, 2012, P NATL ACAD SCI USA, V109, P5523, DOI 10.1073/pnas.1108220109
   Serné EH, 2007, HYPERTENSION, V50, P204, DOI 10.1161/HYPERTENSIONAHA.107.089680
   Shimoni Y, 2005, J PHYSIOL-LONDON, V567, P177, DOI 10.1113/jphysiol.2005.090639
   Sonesson C, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-016-0356-y
   Stojanovski D, 2003, EXP PHYSIOL, V88, P57, DOI 10.1113/eph8802501
   Tanajak P, 2018, J ENDOCRINOL, V236, P69, DOI 10.1530/JOE-17-0457
   Tuncay E, 2016, BIOL TRACE ELEM RES, V169, P294, DOI 10.1007/s12011-015-0423-3
   Turan B, 1996, CARDIOVASC RES, V32, P351, DOI 10.1016/0008-6363(96)00071-5
   Turan B, 2011, CURR PHARM DESIGN, V17, P2155, DOI 10.2174/138161211796957454
   Turner N, 2007, DIABETES, V56, P2085, DOI 10.2337/db07-0093
   Uthman L, 2018, DIABETOLOGIA, V61, P722, DOI 10.1007/s00125-017-4509-7
   Vassort G, 2010, CARDIOVASC TOXICOL, V10, P73, DOI 10.1007/s12012-010-9064-0
   Watanabe H, 2010, HEART RHYTHM, V7, P647, DOI 10.1016/j.hrthm.2010.01.012
   Younis F, 2018, J CARDIOVASC PHARM T, V23, P358, DOI 10.1177/1074248418763808
   Zinman B, 2015, NEW ENGL J MED, V373, P2117, DOI 10.1056/NEJMoa1504720
NR 54
TC 129
Z9 139
U1 0
U2 24
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD NOV 17
PY 2018
VL 17
AR 144
DI 10.1186/s12933-018-0790-0
PG 17
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA HA8HB
UT WOS:000450528800001
PM 30447687
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rector, RS
   Warner, SO
   Liu, Y
   Hinton, PS
   Sun, GY
   Cox, RH
   Stump, CS
   Laughlin, MH
   Dellsperger, KC
   Thomas, TR
AF Rector, R. Scott
   Warner, Shana O.
   Liu, Ying
   Hinton, Pamela S.
   Sun, Grace Y.
   Cox, Richard H.
   Stump, Craig S.
   Laughlin, M. Harold
   Dellsperger, Kevin C.
   Thomas, Tom R.
TI Exercise and diet induced weight loss improves measures of oxidative
   stress and insulin sensitivity in adults with characteristics of the
   metabolic syndrome
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE insulin resistance; oxidized low; density lipoprotein; paraoxonase-1;
   energy restriction
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-ARTERY-DISEASE; SHORT-TERM DIET;
   CHOLESTEROL SUBFRACTIONS; PARAOXONASE ACTIVITY; DIABETES-MELLITUS; HDL
   CHOLESTEROL; PLASMA-GLUCOSE; PARTICLE-SIZE; OXIDIZED LDL
AB Obesity and insulin resistance (IR) increase the risk for coronary heart disease; however, much of this risk is not attributable to traditional risk factors. We sought to determine whether weight loss associated with supervised aerobic exercise beneficially alters biomarkers of oxidative stress and whether these alterations are associated with improvements in measures of insulin resistance. Twenty-five sedentary and overweight to obese [body mass index (BMI) = 33.0 +/- 0.8 kg/m(2)] individuals, with characteristics of the metabolic syndrome, participated in a 4- to 7-mo weight loss program that consisted of energy restriction (reduced by similar to 500 kcal/day) and supervised aerobic exercise (5 days/wk, 45 min/day at 60% Vo(2) max; similar to 375 kcal/day). IR and insulin sensitivity were assessed by the calculation of the homeostasis model assessment (HOMA) and quantitative insulin sensitivity check index (QUICKI), respectively. Oxidative stress was assessed by oxidized LDL (oxLDL), myeloperoxidase (MPO), and low- and high-density lipoprotein (LDL and HDL) lipid hydroperoxide concentrations in serum. Indexes for antioxidative status included apolipoprotein A1 (apoA1) concentrations and paraoxonase-1 (PON1) activity and protein concentrations. Exercise- and diet-induced weight loss (similar to 10%) significantly (P < 0.05) increased insulin sensitivity and reduced IR, oxLDL, and LDL lipid hydroperoxides but did not alter HDL lipid hydroperoxides or MPO concentrations. Lifestyle modification impacted systemic antioxidative status by increasing apoA1 concentrations and reducing serum PON1 protein and activity. Changes in oxidative stress were not associated with alterations in HOMA or QUICKI. Diet- and exercise- induced weight loss (similar to 10%) improves measures of insulin sensitivity and beneficially alters biomarkers of oxidative status.
C1 Univ Missouri, Dept Nutr Sci, Exercise Physiol Program, Columbia, MO 65211 USA.
   Univ Missouri, Dept Biochem, Columbia, MO 65211 USA.
   Univ Missouri, Sch Educ, Columbia, MO 65211 USA.
   Univ Missouri, Dept Biomed Sci, Columbia, MO 65211 USA.
   Univ Missouri, Dept Internal Med, Columbia, MO 65211 USA.
   Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO 65211 USA.
   Univ Arizona, Ctr Diabet Res, Dept Med, Tucson, AZ 85721 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Arizona
RP Thomas, TR (corresponding author), Univ Missouri, Dept Nutr Sci, Exercise Physiol Program, Columbia, MO 65211 USA.
EM thomastr@missouri.edu
OI Hinton, Pamela/0000-0003-0979-0451; Rector, R. Scott/0000-0001-9908-7123
FU NHLBI NIH HHS [R01 HL036088] Funding Source: Medline; NIAMS NIH HHS [T32
   AR48523, T32 AR048523] Funding Source: Medline; NIDDK NIH HHS [R0I
   DK67036, R01 DK067036] Funding Source: Medline
CR ABBOTT CA, 1995, ARTERIOSCL THROM VAS, V15, P1812, DOI 10.1161/01.ATV.15.11.1812
   [Anonymous], ACSMS GUID EX TEST P
   Aviram M, 2000, CIRCULATION, V101, P2510, DOI 10.1161/01.CIR.101.21.2510
   BASIOTIS PP, 2002, HEALTHY EATING INDEX
   BERGMAN RN, 1985, ENDOCR REV, V6, P45, DOI 10.1210/edrv-6-1-45
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   BUCALA R, 1993, P NATL ACAD SCI USA, V90, P6434, DOI 10.1073/pnas.90.14.6434
   Chen NG, 2000, ATHEROSCLEROSIS, V152, P203, DOI 10.1016/S0021-9150(99)00460-8
   CHUNG BH, 1986, METHOD ENZYMOL, V128, P181
   Durrington PN, 2001, ARTERIOSCL THROM VAS, V21, P473, DOI 10.1161/01.ATV.21.4.473
   Ferretti G, 2005, J CLIN ENDOCR METAB, V90, P1728, DOI 10.1210/jc.2004-0486
   Freedman DS, 1998, ARTERIOSCL THROM VAS, V18, P1046, DOI 10.1161/01.ATV.18.7.1046
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Galassetti PR, 2006, J INVEST MED, V54, P67, DOI 10.2310/6650.2005.05024
   Grundy SM, 2005, ARTERIOSCL THROM VAS, V25, P2243, DOI 10.1161/01.ATV.0000189155.75833.c7
   Ho RC, 2002, METABOLISM, V51, P1478, DOI 10.1053/meta.2002.35577
   Holvoet P, 2001, ARTERIOSCL THROM VAS, V21, P844, DOI 10.1161/01.ATV.21.5.844
   Houmard JA, 2004, J APPL PHYSIOL, V96, P101, DOI 10.1152/japplphysiol.00707.2003
   JIANG ZY, 1992, ANAL BIOCHEM, V202, P384, DOI 10.1016/0003-2697(92)90122-N
   KARHAPAA P, 1994, DIABETES, V43, P411, DOI 10.2337/diabetes.43.3.411
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   Katzmarzyk PT, 2003, MED SCI SPORT EXER, V35, P1703, DOI 10.1249/01.MSS.0000089337.73244.9B
   Klein S, 2004, DIABETES CARE, V27, P2067, DOI 10.2337/diacare.27.8.2067
   Laakso M, 1996, ANN MED, V28, P415, DOI 10.3109/07853899608999101
   Maddux BA, 2001, DIABETES, V50, P404, DOI 10.2337/diabetes.50.2.404
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mazière C, 2004, ATHEROSCLEROSIS, V175, P23, DOI 10.1016/j.atherosclerosis.2004.02.006
   Nicholls SJ, 2005, ARTERIOSCL THROM VAS, V25, P1102, DOI 10.1161/01.ATV.0000163262.83456.6d
   PYORALA K, 1987, Diabetes Metabolism Reviews, V3, P463
   Richter B, 2005, THROMB HAEMOSTASIS, V94, P1306, DOI 10.1160/TH05-03-0158
   Roberts CK, 2006, J APPL PHYSIOL, V101, P1727, DOI 10.1152/japplphysiol.00345.2006
   Roberts CK, 2006, J APPL PHYSIOL, V100, P1657, DOI 10.1152/japplphysiol.01292.2005
   Ruaño G, 2006, ATHEROSCLEROSIS, V185, P65, DOI 10.1016/j.atherosclerosis.2005.05.029
   Sentí M, 2003, J CLIN ENDOCR METAB, V88, P5422, DOI 10.1210/jc.2003-030648
   Shao BH, 2006, CURR OPIN CARDIOL, V21, P322, DOI 10.1097/01.hco.0000231402.87232.aa
   Soukharev S, 2004, ANAL BIOCHEM, V327, P140, DOI 10.1016/j.ab.2004.01.001
   Stocker R, 2004, PHYSIOL REV, V84, P1381, DOI 10.1152/physrev.00047.2003
   Thompson PD, 1997, METABOLISM, V46, P217, DOI 10.1016/S0026-0495(97)90305-X
   Tomás M, 2002, J LIPID RES, V43, P713
   Uzun H, 2004, OBES SURG, V14, P659, DOI 10.1381/096089204323093453
   WILLIAMS PT, 1992, METABOLISM, V41, P441, DOI 10.1016/0026-0495(92)90082-L
   Zhang JQ, 1998, J APPL PHYSIOL, V85, P1516, DOI 10.1152/jappl.1998.85.4.1516
   Ziegler S, 2006, ARCH PHYS MED REHAB, V87, P265, DOI 10.1016/j.apmr.2005.09.025
NR 43
TC 103
Z9 118
U1 0
U2 2
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD AUG
PY 2007
VL 293
IS 2
BP E500
EP E506
DI 10.1152/ajpendo.00116.2007
PG 7
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 196CA
UT WOS:000248458100009
PM 17473052
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Braun, JM
   Buckley, JP
   Cecil, KM
   Chen, AM
   Kalkwarf, HJ
   Lanphear, BP
   Xu, YY
   Woeste, A
   Yolton, K
AF Braun, Joseph M.
   Buckley, Jessie P.
   Cecil, Kim M.
   Chen, Aimin
   Kalkwarf, Heidi J.
   Lanphear, Bruce P.
   Xu, Yingying
   Woeste, Anastasia
   Yolton, Kimberly
TI Adolescent follow-up in the Health Outcomes and Measures of the
   Environment (HOME) Study: cohort profile
SO BMJ OPEN
LA English
DT Article
DE epidemiology; paediatrics; toxicology
ID BISPHENOL-A EXPOSURE; PHYSICAL-ACTIVITY; PRENATAL EXPOSURE;
   UNITED-STATES; CORD BLOOD; CHILDREN; BIRTH; AGE; DISORDERS; DISEASE
AB Purpose Environmental chemical exposures may adversely affect an array of adolescent health outcomes. Thus, we used the Health Outcomes and Measures of the Environment (HOME) study, a prospective cohort that recruited pregnant women and conducted longitudinal follow-up on children over the first 12 years of life, to determine if and when chemical exposures affect adolescent health.
   Participants We recruited 468 pregnant women (age range: 18-45 years) from the Cincinnati, Ohio region to participate in a cohort study between March 2003 and January 2006. Follow-up included two clinic and one home visits during pregnancy, a delivery hospital visit, and four home and six clinic visits when children were aged 4 weeks and 1, 2, 3, 4, 5 and 8 years. Of 441 children available for follow-up, 396 (90%) completed at least one follow-up and 256 (58%) completed the most recent follow-up at 12 years of age (range: 11-14).
   Findings to date Our new measures include maternal/child report of internalising symptoms, neuroimaging, dual-energy X-ray absorptiometry-derived estimates of lean/adipose tissue and bone mineral density, and cardiometabolic risk biomarkers. We assessed adolescent exposure to perfluoroalkyl substances, phenols, phthalates and flame retardants. Participants completing follow-up at 12 years of age were similar to the original cohort in terms of baseline factors. Most children had typical and expected values for this age on measures of internalising symptoms, body composition, bone density and cardiometabolic risk markers. Notably, 36% and 11% of children had scores indicative of potential anxiety and depressive disorders, respectively. Approximately 35% of children were overweight or obese, with higher prevalence among girls. Thirty-three per cent of children had borderline or high triglyceride concentrations (>90 mg/dL).
   Future plans We will examine associations of early life environmental chemical exposures with adolescent health measures while considering potential periods of heightened susceptibility and mixture effects.
C1 [Braun, Joseph M.] Brown Univ, Dept Epidemiol, Providence, RI 02912 USA.
   [Buckley, Jessie P.] Johns Hopkins Univ, Dept Environm Hlth & Engn, Bloomberg Sch Publ Hlth, Baltimore, MD USA.
   [Cecil, Kim M.] Cincinnati Childrens Hosp Med Ctr, Dept Radiol, Cincinnati, OH 45229 USA.
   [Chen, Aimin] Univ Penn, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 USA.
   [Kalkwarf, Heidi J.; Xu, Yingying; Woeste, Anastasia; Yolton, Kimberly] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA.
   [Lanphear, Bruce P.] Simon Fraser Univ, Fac Hlth Sci, Burnaby, BC, Canada.
C3 Brown University; Johns Hopkins University; Johns Hopkins Bloomberg
   School of Public Health; Cincinnati Children's Hospital Medical Center;
   University of Pennsylvania; Cincinnati Children's Hospital Medical
   Center; Simon Fraser University
RP Braun, JM (corresponding author), Brown Univ, Dept Epidemiol, Providence, RI 02912 USA.
EM joseph_braun_1@brown.edu; kimberly.yolton@cchmc.org
RI Yunkunis, Kimberly/AAO-5605-2021
OI Yolton, Kimberly/0000-0002-4458-0516
FU National Institutes of Environmental Health Sciences [R01 ES027224, R01
   ES025214, R01 ES028277, R01 ES030078, R01 ES024381, R01 ES020349, P01
   ES011261, R01 ES014575, R01 ES015517]
FX The HOME Study was funded by National Institutes of Environmental Health
   Sciences grants R01 ES027224, R01 ES025214, R01 ES028277, R01 ES030078,
   R01 ES024381, R01 ES020349, P01 ES011261, R01 ES014575, and R01
   ES015517.
CR Akresh R, 2012, J DEV ECON, V99, P330, DOI 10.1016/j.jdeveco.2012.04.001
   [Anonymous], 2017, FAMINES STUNTING ARE
   [Anonymous], 2015, BRIEF RATING INVENTO
   [Anonymous], 1985, PSYCHOPHARMACOL BULL
   [Anonymous], 2017, World population projected to reach 9.8 billion in 2050
   [Anonymous], 2018, Fourth National Report on Human Exposure to Environmental Chemicals
   Arora M, 2013, CURR OPIN PEDIATR, V25, P261, DOI 10.1097/MOP.0b013e32835e9084
   Axelrad DA, 2007, ENVIRON HEALTH PERSP, V115, P609, DOI 10.1289/ehp.9303
   Beck A.T., 1996, BDI-II
   Benowitz NL, 2009, AM J EPIDEMIOL, V169, P236, DOI 10.1093/aje/kwn301
   Berenson GS, 1998, NEW ENGL J MED, V338, P1650, DOI 10.1056/NEJM199806043382302
   Birmaher B, 1999, J AM ACAD CHILD PSY, V38, P1230, DOI 10.1097/00004583-199910000-00011
   Braun JM, 2018, JAMA PEDIATR, V172, P934, DOI 10.1001/jamapediatrics.2018.2382
   Braun JM, 2017, NAT REV ENDOCRINOL, V13, P161, DOI 10.1038/nrendo.2016.186
   Braun JM, 2017, INT J EPIDEMIOL, V46, P24, DOI 10.1093/ije/dyw006
   Braun JM, 2016, OBESITY, V24, P231, DOI 10.1002/oby.21258
   Buckley JP, 2016, EPIDEMIOLOGY, V27, P449, DOI 10.1097/EDE.0000000000000436
   Carnell S, 2007, APPETITE, V48, P104, DOI 10.1016/j.appet.2006.07.075
   CDC, 2009, 2000 CDC GROWTH CHAR
   CfDCaP CDC, 2012, 4 CDCP
   Chandler JL, 2016, PEDIATR OBES, V11, P120, DOI 10.1111/ijpo.12033
   Chen AM, 2014, ENVIRON HEALTH PERSP, V122, P856, DOI 10.1289/ehp.1307562
   Constantino JN., 2012, Western Psychological Services
   Crouter SE, 2015, MED SCI SPORT EXER, V47, P944, DOI 10.1249/MSS.0000000000000502
   Dahlberg LL, 2005, MEASUING VIOLENCE RE
   Derogatis L.R., 2004, Symptom Checklist-90-R
   Dorn LD, 2019, J RES ADOLESCENCE, V29, P155, DOI 10.1111/jora.12431
   Elliott, 2008, SOCIAL SKILLS IMPROV
   Emmett EA, 2006, J OCCUP ENVIRON MED, V48, P759, DOI 10.1097/01.jom.0000232486.07658.74
   Engel SM, 2016, ENVIRON HEALTH PERSP, V124, P822, DOI 10.1289/ehp.1409474
   Etzel TM, 2017, ENVIRON RES, V156, P505, DOI 10.1016/j.envres.2017.04.015
   Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents, 2011, Pediatrics, V128 Suppl 5, pS213, DOI 10.1542/peds.2009-2107C
   Frisbee SJ, 2009, ENVIRON HEALTH PERSP, V117, P1873, DOI 10.1289/ehp.0800379
   GILLMAN MW, 1995, CIRCULATION, V92, P1049, DOI 10.1161/01.CIR.92.4.1049
   Harley KG, 2016, ENVIRON HEALTH PERSP, V124, P1084, DOI 10.1289/ehp.1409362
   Heindel JJ, 2015, ENDOCRINOLOGY, V156, P3416, DOI 10.1210/EN.2015-1394
   HERBST AL, 1971, NEW ENGL J MED, V284, P878, DOI 10.1056/NEJM197104222841604
   Hoover RN, 2011, NEW ENGL J MED, V365, P1304, DOI 10.1056/NEJMoa1013961
   Institute NC, 2017, HLTH EAT IND POP RAT
   Instruments L, GROOVED PEGBOARD
   Jenny NS, 2016, GLOB HEART, V11, P327, DOI 10.1016/j.gheart.2016.07.003
   Juraska JM, 2013, HORM BEHAV, V64, P203, DOI 10.1016/j.yhbeh.2013.05.010
   Kalloo G, 2020, ENVIRON INT, V134, DOI 10.1016/j.envint.2019.105219
   Kamphaus R.W., 2008, PARENTING RELATIONSH
   Kingsley SL, 2019, METABOLOMICS, V15, DOI 10.1007/s11306-019-1560-z
   Kingsley SL, 2017, ENVIRON RES, V158, P174, DOI 10.1016/j.envres.2017.06.013
   Kowalski K., The Physical Activity Questionnaire for Older Children (PAQ-C) and Adolescents (PAQ-A) Manual
   Lanphear BP, 2005, PLOS MED, V2, P203, DOI 10.1371/journal.pmed.0020061
   Li N, 2019, PSYCHONEUROENDOCRINO, V99, P257, DOI 10.1016/j.psyneuen.2018.10.021
   Matthews CE, 2012, MED SCI SPORT EXER, V44, pS68, DOI 10.1249/MSS.0b013e3182399e5b
   McGill HC, 2008, CIRCULATION, V117, P1216, DOI 10.1161/CIRCULATIONAHA.107.717033
   Merikangas KR, 2010, J AM ACAD CHILD PSY, V49, P980, DOI 10.1016/j.jaac.2010.05.017
   Messiah SE, 2011, METAB SYNDR RELAT D, V9, P297, DOI 10.1089/met.2010.0127
   Morrison JA, 2007, PEDIATRICS, V120, P340, DOI 10.1542/peds.2006-1699
   Newschaffer CJ, 2012, J NEURODEV DISORD, V4, DOI 10.1186/1866-1955-4-7
   Ogden Cynthia L, 2011, Natl Health Stat Report, P1
   Paus T, 2008, NAT REV NEUROSCI, V9, P947, DOI 10.1038/nrn2513
   PERLOFF D, 1993, CIRCULATION, V88, P2460, DOI 10.1161/01.CIR.88.5.2460
   Phelan KJ, 2011, ARCH PEDIAT ADOL MED, V165, P339, DOI 10.1001/archpediatrics.2011.29
   Reynolds CK, 2015, BEHAV RATING SYSTEM
   Sears Clara G, 2019, Environ Epidemiol, V3, DOI 10.1097/EE9.0000000000000061
   Sheehan P, 2017, LANCET, V390, P1792, DOI 10.1016/S0140-6736(17)30872-3
   Sherman E.M. S., 2015, Child and Adolescent Memory Profile (ChAMP)
   Shoaff J, 2017, ENVIRON HEALTH PERSP, V125, DOI 10.1289/EHP1022
   Singh AS, 2008, OBES REV, V9, P474, DOI 10.1111/j.1467-789X.2008.00475.x
   Sinha R, 2016, CANCER EPIDEM BIOMAR, V25, P407, DOI 10.1158/1055-9965.EPI-15-0951
   Spanier AJ, 2014, JAMA PEDIATR, V168, P1131, DOI 10.1001/jamapediatrics.2014.1397
   Spanier AJ, 2012, ENVIRON HEALTH PERSP, V120, P916, DOI 10.1289/ehp.1104175
   Spence SH, 1997, J ABNORM PSYCHOL, V106, P280, DOI 10.1037/0021-843X.106.2.280
   Stacy SL, 2017, ENVIRON INT, V107, P258, DOI 10.1016/j.envint.2017.07.021
   Troiano RP, 2008, MED SCI SPORT EXER, V40, P181, DOI 10.1249/mss.0b013e31815a51b3
   Vrijheid M, 2016, INT J HYG ENVIR HEAL, V219, P331, DOI 10.1016/j.ijheh.2016.05.001
   Vuong AM, 2018, HORM BEHAV, V101, P94, DOI 10.1016/j.yhbeh.2017.11.008
   Wardle J, 2001, J CHILD PSYCHOL PSYC, V42, P963, DOI 10.1111/1469-7610.00792
   Weaver CM, 2016, OSTEOPOROSIS INT, V27, P1281, DOI 10.1007/s00198-015-3440-3
   Woodruff TJ, 2011, ENVIRON HEALTH PERSP, V119, P878, DOI 10.1289/ehp.1002727
NR 76
TC 49
Z9 50
U1 1
U2 7
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2020
VL 10
IS 5
AR e034838
DI 10.1136/bmjopen-2019-034838
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA NQ7LS
UT WOS:000571051700004
PM 32385062
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lu, LJ
   Zhao, D
   Li, C
   Sun, YY
   Geng, FX
   Zhang, SW
   Li, WQ
   Wang, SL
   Pan, YP
AF Lu, Lijie
   Zhao, Dan
   Li, Chen
   Sun, Yangyang
   Geng, Fengxue
   Zhang, Shuwei
   Li, Weiqi
   Wang, Songlin
   Pan, Yaping
TI The role of periodontitis in the development of atherosclerotic
   cardiovascular disease in participants with the components of metabolic
   syndrome: a systematic review and meta-analysis
SO CLINICAL ORAL INVESTIGATIONS
LA English
DT Article
DE Periodontitis; Metabolic syndrome; Cardiovascular disease;
   Arteriosclerosis; Dysglycemia
ID CORONARY-HEART-DISEASE; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   RISK-FACTORS; GLOBAL BURDEN; BONE LOSS; ASSOCIATION; OBESITY; HEALTH;
   PREVALENCE
AB Objectives Prevention of atherosclerotic cardiovascular disease (ASCVD) is important in individuals with metabolic syndrome components (MetS), and periodontitis may play an important role in this process. This study aims to evaluate the association between periodontitis and ASCVD in participants with the components of MetS, including obesity, dysglycemia, hypertension, and dyslipidemia. Materials and methods This study conducted followed the MOOSE reporting guidelines and the PRISMA 2020 guidelines. EMBASE, MEDLINE, Web of Science, Cochrane Library, PubMed and OpenGrey were searched for observational studies about the linkage of periodontitis to ASCVD in people with MetS components up to April 9, 2023. Cohort, case-control and cross-sectional studies were included after study selection. Quality evaluation was carried out using the original and modified Newcastle-Ottawa Scale as appropriate. Random-effects model was employed for meta-analysis. Results Nineteen studies were finally included in the quality analysis, and all of them were assessed as moderate to high quality. Meta-analyses among fifteen studies revealed that the participants with periodontitis were more likely to develop ASCVD in those who have dysglycemia (RR = 1.25, 95% CI = 1.13-1.37; p < 0.05), obesity (RR = 1.13, 95% CI = 1.02-1.24; p < 0.05), dyslipidemia (RR = 1.36, 95% CI = 1.13-1.65; p < 0.05), or hypertension (1.20, 95% CI = 1.05-1.36; p < 0.05). Conclusions Periodontitis promotes the development of ASCVD in participants with one MetS component (obesity, dysglycemia, hypertension or dyslipidemia). Clinical relevanceIn people with MetS components, periodontitis may contribute to the ASCVD incidence.
C1 [Lu, Lijie; Li, Chen; Sun, Yangyang; Geng, Fengxue; Zhang, Shuwei; Pan, Yaping] China Med Univ, Sch & Hosp Stomatol, Dept Periodont, Shenyang, Peoples R China.
   [Lu, Lijie; Li, Chen; Sun, Yangyang; Geng, Fengxue; Zhang, Shuwei; Pan, Yaping] Liaoning Prov Key Lab Oral Dis, Shenyang, Peoples R China.
   [Zhao, Dan] Capital Med Univ, Beijing Stomatol Hosp, Dept Implant Dent, Beijing, Peoples R China.
   [Wang, Songlin] Capital Med Univ, Salivary Gland Dis Ctr, Beijing Key Lab Tooth Regenerat & Funct Reconstruc, Beijing 100050, Peoples R China.
   [Wang, Songlin] Capital Med Univ, Beijing Stomatol Hosp, Beijing 100050, Peoples R China.
   [Li, Weiqi] Sichuan Univ, West China Hosp Stomatol, Chinese Acad Med Sci,Res Unit Oral Carcinogenesis, Natl Clin Res Ctr Oral Dis,State Key Lab Oral Dis, Chengdu, Peoples R China.
C3 China Medical University; Capital Medical University; Capital Medical
   University; Capital Medical University; Sichuan University; Chinese
   Academy of Medical Sciences - Peking Union Medical College
RP Pan, YP (corresponding author), China Med Univ, Sch & Hosp Stomatol, Dept Periodont, Shenyang, Peoples R China.; Pan, YP (corresponding author), Liaoning Prov Key Lab Oral Dis, Shenyang, Peoples R China.; Wang, SL (corresponding author), Capital Med Univ, Salivary Gland Dis Ctr, Beijing Key Lab Tooth Regenerat & Funct Reconstruc, Beijing 100050, Peoples R China.; Wang, SL (corresponding author), Capital Med Univ, Beijing Stomatol Hosp, Beijing 100050, Peoples R China.
EM slwang@ccmu.edu.cn; yppan@cmu.edu.cn
RI Zhao, Dan/LIR-1489-2024; Li, Weiqi/KEH-5075-2024; 孙, 洋洋/JPA-6465-2023
OI Zhao, Dan/0000-0002-0037-1464
FU Beijing Stomatological Hospital, Capital Medical University Young
   Scientist Program
FX No Statement Available
CR Abdalla-Aslan R, 2019, J ORAL REHABIL, V46, P647, DOI 10.1111/joor.12798
   Aggarwal K, 2022, QUINTESSENCE INT, V53, P144, DOI 10.3290/j.qi.b2091191
   Ahmadi-Motamayel F, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00189
   Ärnlöv J, 2010, CIRCULATION, V121, P230, DOI 10.1161/CIRCULATIONAHA.109.887521
   Arsiwala LT, 2022, J PERIODONTOL, V93, P943, DOI 10.1002/JPER.21-0342
   Bahekar AA, 2007, AM HEART J, V154, P830, DOI 10.1016/j.ahj.2007.06.037
   Bamba V, 2007, GASTROENTEROLOGY, V132, P2181, DOI 10.1053/j.gastro.2007.03.056
   Boillot A, 2015, J CLIN PERIODONTOL, V42, P342, DOI 10.1111/jcpe.12388
   Brodala N, 2005, ARTERIOSCL THROM VAS, V25, P1446, DOI 10.1161/01.ATV.0000167525.69400.9c
   Bullon P, 2009, J DENT RES, V88, P503, DOI 10.1177/0022034509337479
   Bullon P, 2014, PERIODONTOL 2000, V64, P139, DOI 10.1111/j.1600-0757.2012.00455.x
   Byon MJ, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17197261
   Casarin RCV, 2013, J PERIODONTAL RES, V48, P30, DOI 10.1111/j.1600-0765.2012.01498.x
   Chapman MJ, 2008, PHARMACOL THERAPEUT, V117, P354, DOI 10.1016/j.pharmthera.2007.10.004
   Chen L, 2018, DIABETES RES CLIN PR, V135, P37, DOI 10.1016/j.diabres.2017.10.008
   Cho DH, 2020, ATHEROSCLEROSIS, V297, P96, DOI 10.1016/j.atherosclerosis.2020.02.012
   Cornier MA, 2008, ENDOCR REV, V29, P777, DOI 10.1210/er.2008-0024
   D'Aiuto F, 2006, AM HEART J, V151, P977, DOI 10.1016/j.ahj.2005.06.018
   D'Isidoro O, 2019, AM J DENT, V32, P191
   Desvarieux M, 2010, J HYPERTENS, V28, P1413, DOI 10.1097/HJH.0b013e328338cd36
   Duval S, 2000, BIOMETRICS, V56, P455, DOI 10.1111/j.0006-341X.2000.00455.x
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Ference BA, 2017, EUR HEART J, V38, P2459, DOI 10.1093/eurheartj/ehx144
   Figuero E, 2011, J PERIODONTOL, V82, P1469, DOI 10.1902/jop.2011.100719
   Genco RJ, 2020, PERIODONTOL 2000, V83, P59, DOI 10.1111/prd.12271
   Graziani F, 2018, J CLIN PERIODONTOL, V45, P167, DOI 10.1111/jcpe.12837
   Guyatt G, 2013, J CLIN EPIDEMIOL, V66, P151, DOI 10.1016/j.jclinepi.2012.01.006
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Hong NJ, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.937201
   Hsu PW, 2022, J CHIN MED ASSOC, V85, P1006, DOI 10.1097/JCMA.0000000000000797
   Iso H, 2021, J AM HEART ASSOC, V10, DOI 10.1161/JAHA.121.020760
   Iwasaki Y, 2019, NUTRIENTS, V11, DOI 10.3390/nu11050990
   Jacobi N, 2021, J CLIN MED, V10, DOI 10.3390/jcm10102048
   Jepsen S, 2020, PERIODONTOL 2000, V83, P125, DOI 10.1111/prd.12326
   Jia R, 2013, J DENT RES, V92, P247, DOI 10.1177/0022034513475625
   Joshipura KJ, 2003, STROKE, V34, P47, DOI 10.1161/01.STR.0000052974.79428.0C
   Khouja T, 2019, J DIABETES COMPLICAT, V33, P603, DOI 10.1016/j.jdiacomp.2019.05.025
   Kim HD, 2010, J PERIODONTOL, V81, P658, DOI 10.1902/jop.2010.090614
   Kim J, 2022, J HYPERTENS, V40, P374, DOI 10.1097/HJH.0000000000003022
   LaMonte MJ, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.116.004518
   Lamprecht R, 2022, J PERIODONTAL RES, V57, P824, DOI 10.1111/jre.13021
   Larsson SC, 2022, EBIOMEDICINE, V82, DOI 10.1016/j.ebiom.2022.104154
   Larvin H, 2022, J PERIODONTOL, V93, P1024, DOI 10.1002/JPER.21-0621
   Larvin H, 2021, CLIN EXP DENT RES, V7, P109, DOI 10.1002/cre2.336
   Lassenius MI, 2011, DIABETES CARE, V34, P1809, DOI 10.2337/dc10-2197
   Leira Y, 2017, EUR J EPIDEMIOL, V32, P43, DOI 10.1007/s10654-016-0170-6
   Li WQ, 2022, FRONT ONCOL, V12, DOI 10.3389/fonc.2022.697399
   Li Y, 2015, J DENT RES, V94, P362, DOI 10.1177/0022034514561658
   Lind L, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-82398-8
   Liu J, 2021, J ENDOCRINOL INVEST, V44, P2333, DOI 10.1007/s40618-021-01603-7
   Loos BG, 2000, J PERIODONTOL, V71, P1528, DOI 10.1902/jop.2000.71.10.1528
   Lu JL, 2017, J CLIN ENDOCR METAB, V102, P507, DOI 10.1210/jc.2016-2477
   Maciel SS, 2016, J CLIN PERIODONTOL, V43, P1003, DOI 10.1111/jcpe.12634
   Mahdavi-Roshan M, 2022, INT J ENDOCRINOL MET, V20, DOI 10.5812/ijem-127445
   Megha KB, 2021, PHYTOMEDICINE, V91, DOI 10.1016/j.phymed.2021.153712
   Meigs JB, 2007, DIABETES CARE, V30, P2529, DOI 10.2337/dc07-0817
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Aguilera EM, 2021, J INTERN MED, V289, P532, DOI 10.1111/joim.13180
   Murthy VL, 2020, JAMA CARDIOL, V5, P1144, DOI 10.1001/jamacardio.2020.2686
   Nepomuceno R, 2017, J CLIN PERIODONTOL, V44, P1192, DOI 10.1111/jcpe.12792
   Nibali L, 2019, CLIN ORAL INVEST, V23, P2695, DOI 10.1007/s00784-018-2667-8
   Nibali L, 2013, J CLIN ENDOCR METAB, V98, P913, DOI 10.1210/jc.2012-3552
   Norhammar A, 2019, DIABETES CARE, V42, P1504, DOI 10.2337/dc19-0018
   Page MJ, 2021, BMJ-BRIT MED J, V372, DOI [10.1136/bmj.n71, 10.1136/bmj.n160]
   Pessi T, 2013, CIRCULATION, V127, P1219, DOI 10.1161/CIRCULATIONAHA.112.001254
   Pirih FQ, 2021, PERIODONTOL 2000, V87, P50, DOI 10.1111/prd.12379
   Pirillo A, 2021, NAT REV CARDIOL, V18, P689, DOI 10.1038/s41569-021-00541-4
   Polak-Szczybylo E, 2022, NUTRIENTS, V14, DOI 10.3390/nu14030643
   Powell-Wiley TM, 2021, CIRCULATION, V143, pE984, DOI 10.1161/CIR.0000000000000973
   Puszkarska A, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000015773
   Rangé H, 2014, ATHEROSCLEROSIS, V236, P448, DOI 10.1016/j.atherosclerosis.2014.07.034
   Redón J, 2003, HYPERTENSION, V41, P1096, DOI 10.1161/01.HYP.0000068370.21009.38
   Ren JH, 2022, COMPUT MATH METHOD M, V2022, DOI 10.1155/2022/9349598
   Reyes L, 2013, J CLIN PERIODONTOL, V40, pS30, DOI [10.1111/jcpe.12079, 10.1902/jop.2013.1340012]
   Rho JH, 2021, J DENT RES, V100, P1367, DOI 10.1177/00220345211008811
   Ronksley PE, 2011, BMJ-BRIT MED J, V342, DOI 10.1136/bmj.d671
   Roohafza H, 2022, EUR J CARDIOVASC NUR, V21, P483, DOI 10.1093/eurjcn/zvab110
   Rosenthal T, 2022, CURR HYPERTENS REP, V24, P325, DOI 10.1007/s11906-022-01194-5
   Roth GA, 2020, J AM COLL CARDIOL, V76, P2982, DOI 10.1016/j.jacc.2020.11.010
   Ruan QJ, 2023, FRONT IMMUNOL, V14, DOI 10.3389/fimmu.2023.1103592
   Saito T, 2003, J PERIODONTOL, V74, P1741, DOI 10.1902/jop.2003.74.12.1741
   Sari A, 2022, CLIN ORAL INVEST, V26, P1713, DOI 10.1007/s00784-021-04144-8
   Sen S, 2021, AM HEART J, V235, P36, DOI 10.1016/j.ahj.2021.01.009
   Shao Jing, 2022, Zhejiang Da Xue Xue Bao Yi Xue Ban, V51, P19, DOI 10.3724/zdxbyxb-2021-0377
   Sheiham A, 2000, COMMUNITY DENT ORAL, V28, P399, DOI 10.1034/j.1600-0528.2000.028006399.x
   Shi BC, 2020, ISME J, V14, P519, DOI 10.1038/s41396-019-0544-3
   Shinjo T, 2019, J PERIODONTOL, V90, P565, DOI 10.1002/JPER.18-0735
   Silva MF, 2018, CLIN ORAL INVEST, V22, P47, DOI 10.1007/s00784-017-2164-5
   Sim SJ, 2008, J PERIODONTOL, V79, P1652, DOI 10.1902/jop.2008.080015 
   Song PG, 2020, LANCET GLOB HEALTH, V8, pE721, DOI 10.1016/S2214-109X(20)30117-0
   Song TJ, 2021, DIABETES METAB, V47, DOI 10.1016/j.diabet.2021.101252
   Southerland JH, 2012, ATHEROSCLEROSIS, V222, P196, DOI 10.1016/j.atherosclerosis.2012.01.026
   Spahis S, 2017, ANTIOXID REDOX SIGN, V26, P445, DOI 10.1089/ars.2016.6756
   Stroup DF, 2000, JAMA-J AM MED ASSOC, V283, P2008, DOI 10.1001/jama.283.15.2008
   Thorstensson H, 1996, J CLIN PERIODONTOL, V23, P194, DOI 10.1111/j.1600-051X.1996.tb02076.x
   Tomás I, 2012, J CLIN PERIODONTOL, V39, P213, DOI 10.1111/j.1600-051X.2011.01784.x
   Tonetti MS, 2017, J CLIN PERIODONTOL, V44, P456, DOI 10.1111/jcpe.12732
   Ullah MI, 2021, PAK J MED SCI, V37, P700, DOI 10.12669/pjms.37.3.3897
   Varela-López A, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051405
   Yeh YT, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph191610057
   Yu YH, 2015, J CLIN PERIODONTOL, V42, P21, DOI 10.1111/jcpe.12335
   Zhang J, 1998, JAMA-J AM MED ASSOC, V280, P1690, DOI 10.1001/jama.280.19.1690
   Zhao D, 2018, J PERIODONTAL RES, V53, P682, DOI 10.1111/jre.12565
NR 104
TC 2
Z9 2
U1 2
U2 4
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1432-6981
EI 1436-3771
J9 CLIN ORAL INVEST
JI Clin. Oral Investig.
PD MAY 27
PY 2024
VL 28
IS 6
AR 339
DI 10.1007/s00784-024-05731-1
PG 14
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA SG7J3
UT WOS:001233365800002
PM 38801482
DA 2025-06-11
ER

PT J
AU Hsu, CC
   Cheng, KC
   Li, YX
   Hsu, PH
   Cheng, JT
   Niu, HS
AF Hsu, Chia-Chen
   Cheng, Kai-Chun
   Li, Yingxiao
   Hsu, Ping-Hao
   Cheng, Juei-Tang
   Niu, Ho-Shan
TI TGR5 Expression Is Associated with Changes in the Heart and Urinary
   Bladder of Rats with Metabolic Syndrome
SO LIFE-BASEL
LA English
DT Article
DE metabolic syndrome; TGR5; etanercept; heart; urinary bladder; rats
ID TUMOR-NECROSIS-FACTOR; TRANSCRIPTION 3; SIGNAL TRANSDUCER; OXIDATIVE
   STRESS; INFLAMMATION; ACTIVATOR; OBESITY; ACID; ETANERCEPT; MODEL
AB Adipose-derived cytokines may contribute to the inflammation that occurs in metabolic syndrome (MetS). The Takeda G protein-coupled receptor (TGR5) regulates energy expenditure and affects the production of pro-inflammatory biomarkers in metabolic diseases. Etanercept, which acts as a tumor necrosis factor (TNF)-alpha antagonist, can also block the inflammatory response. Therefore, the interaction between TNF-alpha and TGR5 expression was investigated in rats with high-fat diet (HFD)-induced obesity. Heart tissues isolated from the HFD-induced MetS rats were analyzed. Changes in TGR5 expression were investigated with lithocholic acid (LCA) as the agonist. Betulinic acid (BA) was used to activate TGR5 in urinary bladders. LCA was more effective in the heart tissues of HFD-fed rats, although etanercept alleviated the function of LCA. STAT3 activation and higher TGR5 expression were observed in the heart tissues collected from HFD-fed rats. Thus, cardiac TGR5 expression is promoted by HFD through STAT3 activation in rats. Moreover, the urinary bladders of female rats fed a HFD showed a low response, which was reversed by etanercept. Relaxation by BA in the bladders was more marked in HFD-fed rats. The high TGR5 expression in HFD-fed rats was characterized using a mRNA assay, and the increased cAMP levels were found to be stimulated by BA in the isolated bladders. Therefore, TGR5 expression increases with a HFD in both the hearts and urinary bladders. Collectively, cytokine-medicated TGR5 activation was observed in the hearts and urinary bladders of rats.
C1 [Hsu, Chia-Chen] Chang Gung Univ Sci & Technol, Grad Inst Gerontol & Hlth Care Management, Taoyuan 33303, Taiwan.
   [Hsu, Chia-Chen] Taipei City Hosp, Dept Otorhinolaryngol, Taipei 10341, Taiwan.
   [Hsu, Chia-Chen] Univ Taipei, Dept Exercise & Hlth Sci, Taipei 11153, Taiwan.
   [Cheng, Kai-Chun] Tajen Univ, Coll Pharm, Dept Pharm, Pingtung 90741, Taiwan.
   [Cheng, Kai-Chun] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Psychosomat Internal Med, Pharmacol Dept Herbal Med, Kagoshima 8908544, Japan.
   [Li, Yingxiao; Niu, Ho-Shan] Tzu Chi Univ Sci & Technol, Dept Nursing, Hualien 970302, Taiwan.
   [Hsu, Ping-Hao] Chung Shan Med Univ, Sch Med, Taichung 40201, Taiwan.
   [Cheng, Juei-Tang] Chi Mei Med Ctr, Dept Med Res, Tainan 71004, Taiwan.
C3 Chang Gung University of Science & Technology; Taipei City Hospital;
   University of Taipei; Kagoshima University; Chung Shan Medical
   University; Chi Mei Hospital
RP Niu, HS (corresponding author), Tzu Chi Univ Sci & Technol, Dept Nursing, Hualien 970302, Taiwan.
EM eardoctorhsu@yahoo.com.tw; kc-cheng@tajen.edu.tw;
   sc145@ems.tcust.edu.tw; andy30817@gmail.com; jtcheng5503@gmail.com;
   ts00@ems.tcust.edu.tw
RI CHEN, JUI-YI/AAV-8854-2021; Cheng, Kai-Chun/LIG-6306-2024
OI Kai Chun, Cheng/0000-0003-4983-4666
CR Axen KV, 2003, J NUTR, V133, P2244, DOI 10.1093/jn/133.7.2244
   Balkwill F, 2009, NAT REV CANCER, V9, P361, DOI 10.1038/nrc2628
   Bayramgurler D, 2013, EUR J PHARMACOL, V710, P67, DOI 10.1016/j.ejphar.2013.04.007
   Bharadwaj U, 2020, PHARMACOL REV, V72, P486, DOI 10.1124/pr.119.018440
   Borst SE, 2005, LIFE SCI, V77, P2156, DOI 10.1016/j.lfs.2005.03.021
   Chan RSM, 2010, INT J ENV RES PUB HE, V7, P765, DOI 10.3390/ijerph7030765
   Chen X, 2018, TOXICOL APPL PHARM, V338, P43, DOI 10.1016/j.taap.2017.11.003
   Chen YF, 2020, MEDIAT INFLAMM, V2020, DOI 10.1155/2020/6318520
   Cheng KC, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-40002-0
   Chytilová A, 2015, ACTA PHYSIOL, V214, P97, DOI 10.1111/apha.12489
   Cole MA, 2011, BASIC RES CARDIOL, V106, P447, DOI 10.1007/s00395-011-0156-1
   Dai SP, 2019, ARCH MED SCI, V15, P337, DOI 10.5114/aoms.2018.72609
   Das Arghya, 2011, Endocrine Metabolic & Immune Disorders-Drug Targets, V11, P23
   Desai MS, 2013, HEART, V99, P1629, DOI 10.1136/heartjnl-2013-304546
   Desai MS, 2010, HEPATOLOGY, V51, P2097, DOI 10.1002/hep.23585
   Eblimit Z, 2018, CARDIOVASC THER, V36, DOI 10.1111/1755-5922.12462
   Guo C, 2016, FRONT PHYSIOL, V7, DOI 10.3389/fphys.2016.00646
   Hartupee J, 2017, CIRC-HEART FAIL, V10, DOI 10.1161/CIRCHEARTFAILURE.117.004252
   Huang SL, 2019, METABOLISM, V99, P45, DOI 10.1016/j.metabol.2019.07.003
   Juan YS, 2012, BJU INT, V110, pE236, DOI 10.1111/j.1464-410X.2012.11258.x
   Jung JE, 2005, FASEB J, V19, P1296, DOI 10.1096/fj.04-3099fje
   Kadir SHSA, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009689
   Kuo Y.F., 2019, INTEGR MOL MED, V6, P1, DOI [10.15761/IMM.1000366, DOI 10.15761/IMM.1000366]
   Li JZ, 2020, BIOSCIENCE REP, V40, DOI 10.1042/BSR20193482
   Li Q, 2017, BRAZ J MED BIOL RES, V50, DOI [10.1590/1414-431X20175868, 10.1590/1414-431x20175868]
   Li WX, 2016, SCI REP-UK, V6, DOI 10.1038/srep24580
   Li YX, 2017, DRUG DES DEV THER, V11, P1127, DOI 10.2147/DDDT.S131892
   Liao PC, 2013, INFLAMM RES, V62, P89, DOI 10.1007/s00011-012-0555-2
   Liu KM, 2015, AM J PHYSIOL-RENAL, V309, pF318, DOI 10.1152/ajprenal.00607.2014
   Lo SH, 2016, DRUG DES DEV THER, V10, P2669, DOI 10.2147/DDDT.S113197
   Ma YJ, 2015, PHARM RES-DORDR, V32, P1200, DOI 10.1007/s11095-014-1526-9
   Miller AM, 2011, HEPATOLOGY, V54, P846, DOI 10.1002/hep.24517
   Mori T, 2011, INT IMMUNOL, V23, P701, DOI 10.1093/intimm/dxr077
   Murdaca G, 2014, EXPERT OPIN DRUG MET, V10, P1703, DOI 10.1517/17425255.2014.970165
   Nolan Paul B, 2017, Prev Med Rep, V7, P211, DOI 10.1016/j.pmedr.2017.07.004
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Prabhu SD, 2004, CIRC RES, V95, P1140, DOI 10.1161/01.RES.0000150734.79804.92
   Rocha VZ, 2009, NAT REV CARDIOL, V6, P399, DOI 10.1038/nrcardio.2009.55
   Speyer CL, 2011, J INVEST SURG, V24, P18, DOI 10.3109/08941939.2010.521232
   Tiwari A, 2009, DRUG DISCOV TODAY, V14, P523, DOI 10.1016/j.drudis.2009.02.005
   Wang CM, 2016, J DIABETES COMPLICAT, V30, P1426, DOI 10.1016/j.jdiacomp.2016.07.005
   Yida Z, 2015, J BIOMED SCI, V22, DOI 10.1186/s12929-015-0211-6
   Zgheib Carlos, 2012, JAKSTAT, V1, P101, DOI 10.4161/jkst.19776
   Zhou H, 2020, JCI INSIGHT, V5, DOI 10.1172/jci.insight.138881
   Zhu JX, 2006, CYTOKINE, V34, P96, DOI 10.1016/j.cyto.2006.04.010
   Zhu JZ, 2016, SCI REP-UK, V6, DOI 10.1038/srep21358
NR 46
TC 3
Z9 4
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD JUL
PY 2021
VL 11
IS 7
AR 695
DI 10.3390/life11070695
PG 14
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA TO3PN
UT WOS:000676828200001
PM 34357066
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sewani-Rusike, CR
   Buso, A
   Engwa, GA
   Nkeh-Chungag, BN
AF Sewani-Rusike, Constance R.
   Buso, Andiswa
   Engwa, Godwill A.
   Nkeh-Chungag, Benedicta N.
TI In utero exposure to Hypoxis hemerocallidea Fisch., C.A.Mey. &
   Ave-Lall. improves metabolic syndrome parameters in pregnant rats and
   offspring
SO JOURNAL OF PHARMACY & PHARMACOGNOSY RESEARCH
LA English
DT Article
DE Hypoxis hemerocallidea; intrauterine programming; insulin resistance;
   metabolic syndrome
ID POTATO AQUEOUS EXTRACT; INSULIN-RESISTANCE; BIRTH-WEIGHT; OBESITY; DIET;
   EXPRESSION; CHILDHOOD; STRESS; PLANTS; RISK
AB Context: Intrauterine and early life environments contribute to adult metabolic phenotype. Use of medicinal plants like Hypoxis hemerocallidea during pregnancy raises the question of whether this species may have epigenetic benefits or detriments due to intrauterine-programming, which is phenotypically expressed in the offspring.
   Aims: To evaluate the effect of H. hemerocallidea on selected markers of metabolic syndrome on dams and their pups (offspring).
   Methods: Pregnant female Wistar rats (n=18) were divided into three treatment groups (n=6/group): Ethanol extract of H. hemerocallidea at 150 and 300 mg/kg b.w and the control (distilled water) were administered for 21 days. Body weights were monitored and oral glucose tolerance was determined for dams on day 20 of gestation and for pups 28 days postpartum. Serum total antioxidant capacity (TAC), LDL and HDL were determined 28 days postpartum.
   Results: H. hemerocallidea had no effect on body and organ weights of the treated dams. Pups born to H. hemerocallidea dams had reduced visceral fat compared to the untreated controls. H. hemerocallidea increased the glucose tolerance of treated dams and their pups compared to untreated controls. H. hemerocallidea extract increased serum HDL in treated dams while it decreased LDL in pups born to treated dams. H. hemerocallidea increased TAC in pups born to treated dams.
   Conclusions: H. hemerocallidea protected pregnant dams and their pups from insulin resistance, improved lipid profiles, reduced visceral fat accumulation and boosted total antioxidant capacity in pups. These protective effects of H. hemerocallidea in pups may have resulted from intrauterine programming during pregnancy.
C1 [Sewani-Rusike, Constance R.; Buso, Andiswa] Walter Sisulu Univ, Fac Hlth Sci, Dept Human Biol, PBX1, ZA-5117 Mthatha, South Africa.
   [Engwa, Godwill A.; Nkeh-Chungag, Benedicta N.] Walter Sisulu Univ, Fac Nat Sci, Dept Biol & Environm Sci, PBX1, ZA-5117 Mthatha, South Africa.
C3 Walter Sisulu University; Walter Sisulu University
RP Sewani-Rusike, CR (corresponding author), Walter Sisulu Univ, Fac Hlth Sci, Dept Human Biol, PBX1, ZA-5117 Mthatha, South Africa.
EM crusike@wsu.ac.za
RI Chungag, Benedicta/AAU-8632-2021; Engwa, Godwill/T-1577-2017
OI Sewani-Rusike, Constance/0000-0002-3295-2933
FU South African Medical Research Council (SAMRC)
FX Authors acknowledge the South African Medical Research Council (SAMRC)
   for funding through the Self-Initiated Research (SIR) grant awarded to
   C.R. Sewani-Rusike (MRCRusike).
CR Abdillahi HS, 2013, PLANTA MED, V79, P591, DOI 10.1055/s-0032-1328504
   Adiels M, 2008, ARTERIOSCL THROM VAS, V28, P1225, DOI 10.1161/ATVBAHA.107.160192
   [Anonymous], 2009, 2008 2013 ACTION PLA
   Benzie IFF, 1996, ANAL BIOCHEM, V239, P70, DOI 10.1006/abio.1996.0292
   Boney CM, 2005, PEDIATRICS, V115, pE290, DOI 10.1542/peds.2004-1808
   Buhl ES, 2007, AM J PHYSIOL-ENDOC M, V293, pE1451, DOI 10.1152/ajpendo.00356.2007
   Dalziel SR, 2005, LANCET, V365, P1856, DOI 10.1016/S0140-6736(05)66617-2
   Drewes SE, 2004, S AFR J SCI, V100, P425
   Ebbert JO, 2013, NUTRIENTS, V5, P498, DOI 10.3390/nu5020498
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Godfrey KM, 2010, TRENDS ENDOCRIN MET, V21, P199, DOI 10.1016/j.tem.2009.12.008
   Gregg BE, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-23965-4
   Gutiérrez-Rodelo C, 2017, GAC MED MEX, V153, P214
   Han TS., 2015, Medicine, V43, P80, DOI DOI 10.1016/J.MPMED.2014.11.006
   Henriksen EJ, 2011, FREE RADICAL BIO MED, V51, P993, DOI 10.1016/j.freeradbiomed.2010.12.005
   Inadera H, 2013, ENVIRON HEALTH PREV, V18, P185, DOI 10.1007/s12199-013-0328-8
   Kaido TL, 1997, J ETHNOPHARMACOL, V55, P185, DOI 10.1016/S0378-8741(96)01499-7
   Kooi R. van der, 2006, African Journal of Traditional, Complementary and Alternative Medicines, V3, P11
   Laporta O, 2007, FOOD CHEM, V101, P1425, DOI 10.1016/j.foodchem.2006.03.051
   Levitt NS, 1996, NEUROENDOCRINOLOGY, V64, P412, DOI 10.1159/000127146
   Li SS, 2017, INT J EPIDEMIOL, V46, P1533, DOI [10.1093/ije/dyx211, 10.1093/ije/dyx151]
   Mahomed IM, 2003, METHOD FIND EXP CLIN, V25, P617, DOI 10.1358/mf.2003.25.8.778082
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Ngomane S, 2012, MIDWIFERY, V28, P30, DOI 10.1016/j.midw.2010.11.002
   Nordeng H, 2013, J ETHNOBIOL ETHNOMED, V9, DOI 10.1186/1746-4269-9-67
   Nyakudya TT, 2018, NUTR METAB, V15, DOI 10.1186/s12986-018-0314-7
   Nyinawumuntu A., 2008, J SMOOTH MUSCLE RES, V22, P91
   Nyirenda MJ, 1998, J CLIN INVEST, V101, P2174, DOI 10.1172/JCI1567
   Oguntibeju OO, 2016, EVID-BASED COMPL ALT, V2016, DOI 10.1155/2016/8934362
   Ojewole J A O, 2006, Cardiovasc J S Afr, V17, P166
   Ojewole JAO, 2006, J ETHNOPHARMACOL, V103, P126, DOI 10.1016/j.jep.2005.07.012
   Ormazabal V, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0762-4
   Ouni M, 2015, J CLIN ENDOCR METAB, V100, pE919, DOI 10.1210/jc.2015-1413
   Ozanne SE, 2001, BRIT MED BULL, V60, P143, DOI 10.1093/bmb/60.1.143
   Ozanne SE., 2006, REV GYNAECOL PERINAT, V6, P211, DOI [DOI 10.1016/J.RIGAPP.2006.03.002, DOI 10.1371/journal.pone.0194969]
   Peltzer K, 2008, BMC PUBLIC HEALTH, V8, DOI 10.1186/1471-2458-8-255
   Phillips CM, 2013, NUTRIENTS, V5, P32, DOI 10.3390/nu5010032
   Phillips DIW, 2007, J INTERN MED, V261, P453, DOI 10.1111/j.1365-2796.2007.01801.x
   Phillips DIW, 1996, DIABETOLOGIA, V39, P1119
   Reagan-Shaw S, 2008, FASEB J, V22, P659, DOI 10.1096/fj.07-9574LSF
   Roche HM, 2005, P NUTR SOC, V64, P371, DOI 10.1079/PNS2005445
   SABS, 2008, 103862008 SABS SANS
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Samuel VT, 2016, J CLIN INVEST, V126, P12, DOI 10.1172/JCI77812
   Sen S, 2010, DIABETES, V59, P3058, DOI 10.2337/db10-0301
   Sonagra Amit D, 2014, J Clin Diagn Res, V8, pCC01, DOI 10.7860/JCDR/2014/10068.5081
   Srinivasan M, 2006, AM J PHYSIOL-ENDOC M, V290, pE129, DOI 10.1152/ajpendo.00248.2005
   Stumvoll M, 2000, DIABETES CARE, V23, P295, DOI 10.2337/diacare.23.3.295
   Tiya S, 2017, ANDROLOGIA, V49, DOI 10.1111/and.12742
   Torres-Leal FL, 2010, CELL BIOCHEM FUNCT, V28, P623, DOI 10.1002/cbf.1706
   Tsai PP, 2003, LAB ANIM-UK, V37, P314, DOI 10.1258/002367703322389889
   Vanhees K, 2011, TOXICOLOGY, V290, P350, DOI 10.1016/j.tox.2011.10.017
   Varga CA, 1997, SOC SCI MED, V44, P911, DOI 10.1016/S0277-9536(96)00104-9
   Vega CC, 2016, J PHYSIOL-LONDON, V594, P1483, DOI 10.1113/JP271543
   Vehaskari VM, 2001, KIDNEY INT, V59, P238, DOI 10.1046/j.1523-1755.2001.00484.x
   Wang XQ, 2018, CLIN LAB, V64, P945, DOI 10.7754/Clin.Lab.2018.171214
   Waterland RA, 2004, NUTRITION, V20, P63, DOI 10.1016/j.nut.2003.09.011
NR 57
TC 0
Z9 0
U1 0
U2 6
PU JOURNAL PHARMACY & PHARMACOGNOSY RESEARCH-JPPRES
PI ANTOFAGASTA
PA ANGAMOS 0610, ANTOFAGASTA, 00000, CHILE
SN 0719-4250
J9 J PHARM PHARMACOGN R
JI J. Pharm. Pharmacogn. Res.
PD MAR-APR
PY 2021
VL 9
IS 2
BP 113
EP 125
PG 13
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA PB1PK
UT WOS:000596101200001
DA 2025-06-11
ER

PT J
AU Wang, O
   Liu, J
   Cheng, Q
   Guo, XX
   Wang, Y
   Zhao, L
   Zhou, F
   Ji, BP
AF Wang, Ou
   Liu, Jia
   Cheng, Qian
   Guo, Xiaoxuan
   Wang, Yong
   Zhao, Liang
   Zhou, Feng
   Ji, Baoping
TI Effects of Ferulic Acid and γ-Oryzanol on High-Fat and High-Fructose
   Diet-Induced Metabolic Syndrome in Rats
SO PLOS ONE
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; RICE BRAN OIL; INSULIN-RESISTANCE; PLANT
   STEROLS; HEPATIC STEATOSIS; CARDIOVASCULAR RISK; HIGH-CARBOHYDRATE;
   LIPID-METABOLISM; LIVER-DISEASE; HEPG2 CELLS
AB Background
   The high morbidity of metabolic dysfunction diseases has heightened interest in seeking natural and safe compounds to maintain optimal health. gamma-Oryzanol (OZ), the ferulic acid (FA) ester with phytosterols, mainly present in rice bran has been shown to improve markers of metabolic syndrome. This study investigates the effects of FA and OZ on alleviating high-fat and high-fructose diet (HFFD)-induced metabolic syndrome parameters.
   Methods
   Male SD rats were fed with a regular rodent diet, HFFD, or HFFD supplemented with 0.05% FA or 0.16% OZ (equimolar concentrations) for 13 weeks. Food intake, organ indices, serum lipid profiles, glucose metabolism, insulin resistance (IR) index and cytokine levels were analyzed. The mechanisms were further investigated in oleic acid-stimulated HepG2 cells by analyzing triglyceride (TG) content and lipogenesis-related gene expressions.
   Results
   In the in vivo study, FA and OZ exhibited similar effects in alleviating HFFD-induced obesity, hyperlipidemia, hyperglycemia, and IR. However, only OZ treatment significantly decreased liver index and hepatic TG content, lowered serum levels of C-reactive protein and IL-6, and increased serum concentration of adiponectin. In the in vitro assay, only OZ administration significantly inhibited intracellular TG accumulation and down-regulated expression of stearoyl coenzyme-A desaturase-1, which might facilitate OZ to enhance its hepatoprotective effect.
   Conclusion
   OZ is more effective than FA in inhibiting hepatic fat accumulation and inflammation. Thus, FA and OZ could be used as dietary supplements to alleviate the deleterious effects of HFFD.
C1 [Wang, Ou; Cheng, Qian; Guo, Xiaoxuan; Wang, Yong; Zhao, Liang; Zhou, Feng; Ji, Baoping] China Agr Univ, Coll Food Sci & Nutr Engn, Beijing, Peoples R China.
   [Liu, Jia] China Natl Res Inst Food & Fermentat Ind, Beijing, Peoples R China.
C3 China Agricultural University
RP Ji, BP (corresponding author), China Agr Univ, Coll Food Sci & Nutr Engn, Beijing, Peoples R China.
EM jibp330@hotmail.com
RI Wang, Ou/AAE-1806-2022
OI Zhao, Liang/0000-0003-2542-9279
CR Alwahsh SM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0104220
   Ardiansyah, 2006, J AGR FOOD CHEM, V54, P1914, DOI 10.1021/jf052561l
   Ärnlöv J, 2010, CIRCULATION, V121, P230, DOI 10.1161/CIRCULATIONAHA.109.887521
   Baumgartner S, 2011, CURR PHARM DESIGN, V17, P922, DOI 10.2174/138161211795428795
   Berger A, 2005, EUR J NUTR, V44, P163, DOI 10.1007/s00394-004-0508-9
   Chen SJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0045693
   Chotimarkorn C, 2008, PHYTOMEDICINE, V15, P951, DOI 10.1016/j.phymed.2008.02.014
   Cohen JC, 2011, SCIENCE, V332, P1519, DOI 10.1126/science.1204265
   Currie E, 2013, CELL METAB, V18, P153, DOI 10.1016/j.cmet.2013.05.017
   DILLS WL, 1993, AM J CLIN NUTR, V58, P779, DOI 10.1093/ajcn/58.5.779S
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   Frühbeck G, 2001, AM J PHYSIOL-ENDOC M, V280, pE827, DOI 10.1152/ajpendo.2001.280.6.E827
   FUJIWARA S, 1980, YAKUGAKU ZASSHI, V100, P1011, DOI 10.1248/yakushi1947.100.10_1011
   GARCIA MJL, 2009, FOOD CHEM, V115, P389
   Ghatak SB, 2011, CURR NUTR FOOD SCI, V7, P10, DOI 10.2174/157340111794941120
   GRUNFELD C, 1990, ENDOCRINOLOGY, V127, P46, DOI 10.1210/endo-127-1-46
   Hiratsuka T, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013280
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Huang CCJ, 2003, THESIS LOUISIANA STA
   Johnson RJ, 2007, AM J CLIN NUTR, V86, P899
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Kim HK, 2003, CLIN CHIM ACTA, V327, P129, DOI 10.1016/S0009-8981(02)00344-3
   Kozuka C, 2012, DIABETES, V61, P3084, DOI 10.2337/db11-1767
   Li XM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061499
   Liu J, 2014, FOOD FUNCT, V5, P1038, DOI 10.1039/c3fo60524h
   Lomonaco R, 2012, HEPATOLOGY, V55, P1389, DOI 10.1002/hep.25539
   Marra F, 2008, TRENDS MOL MED, V14, P72, DOI 10.1016/j.molmed.2007.12.003
   Micallef MA, 2009, ATHEROSCLEROSIS, V204, P476, DOI 10.1016/j.atherosclerosis.2008.09.020
   Nashed B, 2005, J NUTR, V135, P2438, DOI 10.1093/jn/135.10.2438
   *NAT RES COUNC, 1985, NIH PUBL, V85, P23
   Othman RA, 2011, NUTR REV, V69, P371, DOI 10.1111/j.1753-4887.2011.00399.x
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Pan ZX, 2011, MOL BIOL REP, V38, P3417, DOI 10.1007/s11033-010-0451-1
   Panchal SK, 2010, J BIOMED BIOTECHNOL, V2011, P1
   Panchal SK, 2011, J CARDIOVASC PHARM, V57, P51, DOI [10.1097/FJC.0b013e3181feb90a, 10.1097/FJC.0b013e31821b1379]
   Pfaffl MW, 2001, NUCLEIC ACIDS RES, V29, DOI 10.1093/nar/29.9.e45
   Popa C, 2007, J LIPID RES, V48, P751, DOI 10.1194/jlr.R600021-JLR200
   Postic C, 2008, DIABETES METAB, V34, P643, DOI 10.1016/S1262-3636(08)74599-3
   Poudyal H, 2010, J NUTR, V140, P946, DOI 10.3945/jn.109.117812
   Saltiel AR, 2001, NATURE, V414, P799, DOI 10.1038/414799a
   Silbernagel G, 2013, CURR OPIN LIPIDOL, V24, P12, DOI 10.1097/MOL.0b013e32835b6271
   Simmons RK, 2010, DIABETOLOGIA, V53, P600, DOI 10.1007/s00125-009-1620-4
   Sloboda DM, 2014, J OBESITY, V2014
   Son MJ, 2011, J FOOD SCI, V76, pH7, DOI 10.1111/j.1750-3841.2010.01907.x
   Son MJ, 2010, J CLIN BIOCHEM NUTR, V46, P150, DOI 10.3164/jcbn.09-98
   Srinivasan M, 2007, J CLIN BIOCHEM NUTR, V40, P92, DOI 10.3164/jcbn.40.92
   Tappy L, 2010, PHYSIOL REV, V90, P23, DOI 10.1152/physrev.00019.2009
   Vidyashankar S, 2013, TOXICOL IN VITRO, V27, P945, DOI 10.1016/j.tiv.2013.01.014
   Wijesekara N, 2010, J BIOL CHEM, V285, P33623, DOI 10.1074/jbc.M109.085084
   Wilson TA, 2007, J NUTR BIOCHEM, V18, P105, DOI 10.1016/j.jnutbio.2006.03.006
   Yamauchi T, 2002, NAT MED, V8, P1288, DOI 10.1038/nm788
   Yamauchi T, 2001, NAT MED, V7, P941, DOI 10.1038/90984
   Zhang HJ, 2009, HORM METAB RES, V41, P40, DOI 10.1055/s-0028-1087187
   Zhao ZH, 2008, FOOD CHEM, V109, P691, DOI 10.1016/j.foodchem.2008.02.039
NR 54
TC 110
Z9 117
U1 0
U2 46
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 3
PY 2015
VL 10
IS 2
AR e0118135
DI 10.1371/journal.pone.0118135
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CA3QZ
UT WOS:000348822600100
PM 25646799
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Moon, SS
AF Moon, Seong-Su
TI Additive effect of heavy metals on metabolic syndrome in the Korean
   population: the Korea National Health and Nutrition Examination Survey
   (KNHANES) 2009-2010
SO ENDOCRINE
LA English
DT Article
DE Metabolic syndrome; Heavy metal; Lead; Mercury; Cadmium; Endocrine
   disruptors
ID PERSISTENT ORGANIC POLLUTANTS; ENDOCRINE-DISRUPTING CHEMICALS;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; SERUM CONCENTRATIONS;
   DIABETES-MELLITUS; BLOOD-PRESSURE; LEAD; CADMIUM; EXPOSURE
AB There have been increasing concerns regarding health problems due to endocrine disrupting chemicals (EDCs). We investigated association of heavy metals, including lead, mercury, and cadmium, with metabolic syndrome (MS) and its individual components in the Korean population. Participants included 1,961 males and 1,989 females 20 years of age or older from the fourth and fifth Korea National Health and Nutritional Examination Surveys of the Korean population (2009 and 2010). We examined the relationship of blood lead, mercury, and cadmium levels with MS and the additive effect of three heavy metals on MS after adjustment for age, sex, body mass index (BMI), region, smoking, alcohol consumption, and regular exercise. Blood concentration of lead showed a significant but modest association with prevalence of MS (P = 0.04). Other heavy metals did not show such a relationship with MS. When the participants were classified according to the sum of category numbers of the three heavy metals, adjusted odds ratios were 1.0, 1.355, 1.638, and 1.556 (P < 0.01). Among components of MS, significant relationship of the sum of heavy metals with hypertension and elevated triglyceride was demonstrated. Blood concentration of lead was positively associated with the prevalence of MS. Of particular interest, cumulative effect of a mixture of lead, mercury, and cadmium on prevalence of MS was stronger than the sum of effect of each heavy metal. Accumulative effect of exposure to heavy metals could be more additive or synergistic than individual exposure in the general population.
C1 [Moon, Seong-Su] Dongguk Univ, Coll Med, Dept Internal Med, Gyeongju 780350, Gyeongbuk Provi, South Korea.
   [Moon, Seong-Su] Dongguk Univ, Inst Med, Gyeongju 780350, Gyeongbuk Provi, South Korea.
C3 Dongguk University; Dongguk University
RP Moon, SS (corresponding author), Dongguk Univ, Coll Med, Dept Internal Med, Dongdae Ro 87, Gyeongju 780350, Gyeongbuk Provi, South Korea.
EM drmoonss@hanmail.net
FU Daegu and Kyungpook local committee of the Korean Diabetes Association;
   Dongguk University research fund
FX This research was supported by a grant from the Daegu and Kyungpook
   local committee of the Korean Diabetes Association and by the Dongguk
   University research fund.
CR Ademuyiwa Oladipo, 2005, Lipids Health Dis, V4, P19, DOI 10.1186/1476-511X-4-19
   Afridi HI, 2008, DIABETES RES CLIN PR, V80, P280, DOI 10.1016/j.diabres.2007.12.021
   BELL RR, 1990, TOXICOL LETT, V54, P199, DOI 10.1016/0378-4274(90)90184-N
   Bhatnagar A, 2006, CIRC RES, V99, P692, DOI 10.1161/01.RES.0000243586.99701.cf
   Brodkin E, 2007, CAN MED ASSOC J, V176, P59
   Chang JW, 2011, J HAZARD MATER, V185, P749, DOI 10.1016/j.jhazmat.2010.09.084
   Chen YW, 2009, ISLETS, V1, P169, DOI 10.4161/isl.1.3.9262
   Choi HS, 2011, J CLIN ENDOCR METAB, V96, P643, DOI 10.1210/jc.2010-2133
   COCCO PL, 1991, RES COMMUN CHEM PATH, V72, P81
   Cornier MA, 2008, ENDOCR REV, V29, P777, DOI 10.1210/er.2008-0024
   Diamanti-Kandarakis E, 2009, ENDOCR REV, V30, P293, DOI 10.1210/er.2009-0002
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Henson MC, 2004, EXP BIOL MED, V229, P383, DOI 10.1177/153537020422900506
   Houston MC, 2007, ALTERN THER HEALTH M, V13, P128
   Houston MC, 2011, J CLIN HYPERTENS, V13, P621, DOI 10.1111/j.1751-7176.2011.00489.x
   Jomova K, 2011, TOXICOLOGY, V283, P65, DOI 10.1016/j.tox.2011.03.001
   Kim NS, 2011, INT ARCH OCC ENV HEA, V84, P53, DOI 10.1007/s00420-010-0522-6
   Kim Y, 2012, ENVIRON RES, V118, P124, DOI 10.1016/j.envres.2012.06.003
   Leasure JL, 2008, ENVIRON HEALTH PERSP, V116, P355, DOI 10.1289/ehp.10862
   Lee BK, 1999, TOXICOL LETT, V108, P149, DOI 10.1016/S0378-4274(99)00083-1
   Lee BK, 2013, AM J IND MED, V56, P682, DOI 10.1002/ajim.22107
   Lee DH, 2008, DIABETOLOGIA, V51, P402, DOI 10.1007/s00125-007-0896-5
   Lee DH, 2006, CLIN CHEM, V52, P1825, DOI 10.1373/clinchem.2006.071563
   Lee DH, 2006, DIABETES CARE, V29, P1638, DOI 10.2337/dc06-0543
   Lee SY, 2007, DIABETES RES CLIN PR, V75, P72, DOI 10.1016/j.diabres.2006.04.013
   LUND BO, 1993, BIOCHEM PHARMACOL, V45, P2017, DOI 10.1016/0006-2952(93)90012-L
   MERCIER M, 1990, Journal of Hygiene Epidemiology Microbiology and Immunology (Prague), V34, P1
   Moon SS, 2013, DIABETIC MED, V30, pe143, DOI 10.1111/dme.12103
   Mordukhovich I, 2012, ENVIRON HEALTH PERSP, V120, P98, DOI 10.1289/ehp.1002805
   Navas-Acien A, 2007, ENVIRON HEALTH PERSP, V115, P472, DOI 10.1289/ehp.9785
   Peters JL, 2012, ENVIRON HEALTH PERSP, V120, P361, DOI 10.1289/ehp.1103467
   Rosin A, 2009, ISR MED ASSOC J, V11, P689
   Satarug S, 2004, ENVIRON HEALTH PERSP, V112, P1099, DOI 10.1289/ehp.6751
   Schug TT, 2011, J STEROID BIOCHEM, V127, P204, DOI 10.1016/j.jsbmb.2011.08.007
   Scinicariello F, 2011, ENVIRON RES, V111, P1249, DOI 10.1016/j.envres.2011.08.011
   Serdar MA, 2009, INT J DIABETES DEV C, V29, P35, DOI 10.4103/0973-3930.50713
   Shenker BJ, 1998, ENVIRON RES, V77, P149, DOI 10.1006/enrs.1997.3816
   Swaddiwudhipong W, 2012, ENVIRON RES, V112, P194, DOI 10.1016/j.envres.2011.10.004
   Weisskopf MG, 2009, CIRCULATION, V120, P1056, DOI 10.1161/CIRCULATIONAHA.108.827121
   Whaley-Connell A, 2011, REV CARDIOVASC MED, V12, P21, DOI 10.3909/ricm0555
   Yoon YS, 2004, AM J CLIN NUTR, V80, P217
   You Chang-Hun, 2011, J Prev Med Public Health, V44, P218, DOI 10.3961/jpmph.2011.44.5.218
NR 42
TC 70
Z9 78
U1 2
U2 33
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD JUN
PY 2014
VL 46
IS 2
BP 263
EP 271
DI 10.1007/s12020-013-0061-5
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AI6IU
UT WOS:000336977400015
PM 24065312
DA 2025-06-11
ER

PT J
AU Barona, J
   Jones, JJ
   Kopec, RE
   Comperatore, M
   Andersen, C
   Schwartz, SJ
   Lerman, RH
   Fernandez, ML
AF Barona, Jacqueline
   Jones, Jennifer J.
   Kopec, Rachel E.
   Comperatore, Michael
   Andersen, Catherine
   Schwartz, Steven J.
   Lerman, Robert H.
   Fernandez, Maria Luz
TI A Mediterranean-style low-glycemic-load diet increases plasma
   carotenoids and decreases LDL oxidation in women with metabolic syndrome
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Mediterranean diet; Plasma carotenoids; Oxidized LDL; Metabolic syndrome
ID CARDIOVASCULAR RISK-FACTORS; LOW-DENSITY-LIPOPROTEIN; BETA-CAROTENE;
   BIOMARKERS; CHOLESTEROL; VEGETABLES; FRUITS; ASSOCIATIONS; RESISTANCE;
   ADHERENCE
AB Thirty-five women with metabolic syndrome and high plasma low-density lipoprotein (LDL) cholesterol (>= 100 mg/dl) participated in a dietary intervention consisting of a Mediterranean-style low-glycemic-load diet for 12 weeks. Participants were randomly allocated to consume diet only (n=15) or diet plus a medical food containing soy protein and plant sterols (n=20). Plasma concentrations of carotenoids, lipoprotein subfractions and oxidized LDL (OxLDL) were measured. Independent of treatment, women had a significant increase in plasma lutein (P<.0001) and beta-carotene (P<.0001), while plasma lycopene was reduced (P<.05) after 12 weeks. Low-density lipoprotein cholesterol was reduced from 138 +/- 35 to 114 +/- 33 mg/dl (P<.0001). In addition, decreases were observed in the atherogenic subfractions: large very low-density lipoprotein (P<.05), small LDL (P<.00001) and medium high-density lipoprotein (P<.05). Oxidized LDL was significantly reduced by 12% in both groups (P<.01). Changes in OxLDL were inversely correlated with plasma lutein (r=-.478, P<.0001). The data indicate that women complied with the dietary regimen by increasing fruits and vegetable intake. Decreased consumption of high-glycemic foods frequently co-consumed with lycopene-rich tomato sauce such as pasta and pizza may be responsible for the lowering of this carotenoid in plasma after 12 weeks. These results also suggest that plasma lutein concentrations may protect against oxidative stress by reducing the concentrations of OxLDL (C) 2012 Elsevier Inc. All rights reserved.
C1 [Barona, Jacqueline; Jones, Jennifer J.; Comperatore, Michael; Andersen, Catherine; Fernandez, Maria Luz] Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
   [Barona, Jacqueline] Univ Antioquia, Escuela Microbiol, Medellin, Colombia.
   [Kopec, Rachel E.; Schwartz, Steven J.] Ohio State Univ, Dept Food Sci & Technol, Columbus, OH 43210 USA.
   [Lerman, Robert H.] Metagenics Inc, Funct Med Res Ctr, Gig Harbor, WA 98332 USA.
C3 University of Connecticut; Universidad de Antioquia; University System
   of Ohio; Ohio State University; Metagenics Inc.
RP Fernandez, ML (corresponding author), Univ Connecticut, Dept Nutr Sci, 3624 Horsebarn Rd Ext, Storrs, CT 06269 USA.
EM maria-luz.fernandez@uconn.edu
RI Acevedo, Maria/A-8759-2019; Kopec, Rachel/A-1533-2017
OI Kopec, Rachel/0000-0002-1368-6713; Barona Acevedo, Maria
   Jacqueline/0000-0002-0592-9324; Andersen, Catherine/0000-0001-9774-5030;
   Schwartz, Steven/0000-0002-1427-5780
FU Metagenics, Inc. (Gig Harbor, WA)
FX This study was supported by Metagenics, Inc. (Gig Harbor, WA).
CR AbuMweis SS, 2008, CURR ATHEROSCLER REP, V10, P467, DOI 10.1007/s11883-008-0073-4
   Adiels M, 2006, DIABETOLOGIA, V49, P755, DOI 10.1007/s00125-005-0125-z
   Al-Delaimy WK, 2005, EUR J CLIN NUTR, V59, P1387, DOI 10.1038/sj.ejcn.1602252
   ALLAIN CC, 1974, CLIN CHEM, V20, P470
   Babio N, 2009, PUBLIC HEALTH NUTR, V12, P1607, DOI 10.1017/S1368980009990449
   Bach-Faig A, 2006, PUBLIC HEALTH NUTR, V9, P1110, DOI 10.1017/S1368980007668499
   Bingham SA, 1997, AM J CLIN NUTR, V65, P1130
   Britton G, 2009, CAROTENOIDS SER, V5, P45
   CAMPBELL DR, 1994, CANCER EPIDEM BIOMAR, V3, P493
   Carroll YL, 2000, EUR J CLIN NUTR, V54, P500, DOI 10.1038/sj.ejcn.1601046
   CLEVIDENCE BA, 1993, METHOD ENZYMOL, V214, P33
   Denova-Gutiérrez E, 2010, J NUTR METAB, V2010, DOI 10.1155/2010/170680
   Djuric Z, 2009, NUTR RES, V29, P156, DOI 10.1016/j.nutres.2009.03.001
   Elhayany A, 2010, DIABETES OBES METAB, V12, P204, DOI 10.1111/j.1463-1326.2009.01151.x
   Esposito K, 2010, METAB SYNDR RELAT D, V8, P197, DOI 10.1089/met.2009.0095
   Estruch R, 2006, ANN INTERN MED, V145, P1, DOI 10.7326/0003-4819-145-1-200607040-00004
   Fernandez ML, 2001, CURR OPIN LIPIDOL, V12, P35, DOI 10.1097/00041433-200102000-00007
   Fitó M, 2007, ARCH INTERN MED, V167, P1195, DOI 10.1001/archinte.167.11.1195
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Goulinet S, 1997, ARTERIOSCL THROM VAS, V17, P786, DOI 10.1161/01.ATV.17.4.786
   Greene CM, 2006, NUTR METAB, V3, DOI 10.1186/1743-7075-3-6
   Hulthe J, 2002, ARTERIOSCL THROM VAS, V22, P1162, DOI 10.1161/01.ATV.0000021150.63480.CD
   Kopec RE, 2010, J AGR FOOD CHEM, V58, P3290, DOI 10.1021/jf100415z
   Levy Y, 2000, ANN NUTR METAB, V44, P54, DOI 10.1159/000012821
   Maiani G, 2009, MOL NUTR FOOD RES, V53, pS194, DOI 10.1002/mnfr.200800053
   Mutungi G, 2010, J NUTR BIOCHEM, V21, P261, DOI 10.1016/j.jnutbio.2008.12.011
   Riccardi G, 2008, AM J CLIN NUTR, V87, p269S, DOI 10.1093/ajcn/87.1.269S
   Riccioni G, 2009, CURR ATHEROSCLER REP, V11, P434, DOI 10.1007/s11883-009-0065-z
   Scott KJ, 1996, BRIT J NUTR, V75, P409, DOI 10.1079/BJN19960143
   Serra-Majem L, 2006, NUTR REV, V64, pS27, DOI [10.1111/j.1753-4887.2006.tb00232.x, 10.1301/nr.2006.feb.S27-S47]
   Silaste ML, 2007, BRIT J NUTR, V98, P1251, DOI 10.1017/S0007114507787445
   Sofi F, 2008, BMJ-BRIT MED J, V337, DOI 10.1136/bmj.a1344
   Steinberg D, 1997, CIRCULATION, V95, P1062
   Subar AF, 2003, AM J EPIDEMIOL, V158, P1, DOI 10.1093/aje/kwg092
   Thompson FE, 2010, J AM DIET ASSOC, V110, P48, DOI 10.1016/j.jada.2009.10.008
   Trichopoulou A, 2003, INT J VITAM NUTR RES, V73, P221, DOI 10.1024/0300-9831.73.3.221
   Wang L, 2008, AM J CLIN NUTR, V88, P747, DOI 10.1093/ajcn/88.3.747
   WARNICK GR, 1982, CLIN CHEM, V28, P1379
   Weidner C, 2008, LIPIDS HEALTH DIS, V7, DOI 10.1186/1476-511X-7-35
   Wood RJ, 2006, J NUTR, V136, P384, DOI 10.1093/jn/136.2.384
NR 40
TC 33
Z9 38
U1 0
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD JUN
PY 2012
VL 23
IS 6
BP 609
EP 615
DI 10.1016/j.jnutbio.2011.02.016
PG 7
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 952IK
UT WOS:000304786000012
PM 21775117
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Langdon, KD
   Clarke, J
   Corbett, D
AF Langdon, K. D.
   Clarke, J.
   Corbett, D.
TI LONG-TERM EXPOSURE TO HIGH FAT DIET IS BAD FOR YOUR BRAIN: EXACERBATION
   OF FOCAL ISCHEMIC BRAIN INJURY
SO NEUROSCIENCE
LA English
DT Article
DE sensorimotor function; Western diet; high fat diet; stroke; animal
   models; metabolic syndrome
ID NEUROTROPHIC FACTOR; METABOLIC SYNDROME; CEREBRAL-ISCHEMIA; COGNITIVE
   PERFORMANCE; OXIDATIVE STRESS; RATS; PLASTICITY; EXERCISE;
   ATHEROSCLEROSIS; IMPAIRMENT
AB A diet consisting of high levels of saturated fat has been linked to a dramatic rise in obesity, type II diabetes, and metabolic syndrome. The effect of these co-morbidities on stroke outcome has not been examined in detail in human or animal studies. In this study we hypothesized that maintaining animals on a high fat, "Western diet" (WD), for an extended period would have a detrimental effect on ischemic outcome. Forty-eight male Sprague-Dawley rats were exposed to 1 month of either WD or control diets initiated at 6 weeks of age (Experiment 1) or 3 months of either WD or control diets initiated at 4 weeks of age (Experiment 2) prior to endothelin-1-induced ischemia. Following ischemia, animals were assessed in the staircase reaching and beam-traversing tests at 2 and 4 weeks post-ischemia and infarct volumes were calculated at 4 weeks post-ischemia. Analysis revealed no difference between animals exposed to either WD or control diets for 1 month in behavioral or histological assessments. In contrast, 3 months of WD diet exposure significantly increased functional impairments in both the staircase and beam-traversing tests as well as increasing the volume of infarction, primarily in the cortex. The results of this study demonstrate that long-term exposure to WD diets are detrimental to ischemic outcome. Consequently, it is important to incorporate disease co-morbidities and/or risk factors in pre-clinical evaluation of neuroprotective or restorative interventions if therapies are to be translated into the clinic. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
C1 [Corbett, D.] Univ Ottawa, Fac Med, Dept Cellular & Mol Med, Ottawa, ON K1H 8M5, Canada.
   [Langdon, K. D.; Clarke, J.; Corbett, D.] Mem Univ Newfoundland, Fac Med, Div BioMed Sci, St John, NF A1B 3V6, Canada.
C3 University of Ottawa; Memorial University Newfoundland
RP Corbett, D (corresponding author), Univ Ottawa, Fac Med, Dept Cellular & Mol Med, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada.
EM dcorbett@uottawa.ca
RI Langdon, Kristopher/JDC-7276-2023; Corbett, Dale/D-6625-2011
OI Corbett, Dale/0000-0003-0217-4576
FU Canadian Institutes of Health Research; Canadian Stroke Network; Heart
   and Stroke Foundation of Canada/CIHR/Canadian Stroke
   Network/Astra-Zeneca Focus on Stroke; Natural Sciences and Engineering
   Research Council of Canada
FX The authors thank Suzanne Evans and Sara Dalley for help with behavioral
   assessments and Shirley Granter-Button and Garry Chernenko for their
   technical assistance. This work was supported by operating grants from
   the Canadian Institutes of Health Research and Canadian Stroke Network
   awarded to D. Corbett who holds a Canada Research Chair in Stroke and
   Neuroplasticity. KD Langdon was supported by the Heart and Stroke
   Foundation of Canada/CIHR/Canadian Stroke Network/Astra-Zeneca Focus on
   Stroke Doctoral Fellowship. J Clarke was supported by a doctoral
   fellowship from the Natural Sciences and Engineering Research Council of
   Canada.
CR Arenillas JF, 2007, STROKE, V38, P2196, DOI 10.1161/STROKEAHA.106.480004
   Arvanitidis AP, 2009, BRAIN RES, V1252, P192, DOI 10.1016/j.brainres.2008.11.058
   Brown AD, 2010, NEUROBIOL AGING, V31, P2047, DOI 10.1016/j.neurobiolaging.2008.11.002
   Clarke J, 2009, NEUROREHAB NEURAL RE, V23, P886, DOI 10.1177/1545968309341067
   Cotman CW, 2002, TRENDS NEUROSCI, V25, P295, DOI 10.1016/S0166-2236(02)02143-4
   Dubinion JH, 2010, J HYPERTENS, V28, P1466, DOI 10.1097/HJH.0b013e328339f20e
   Gomez-Pinilla F, 2002, J NEUROPHYSIOL, V88, P2187, DOI 10.1152/jn.00152.2002
   Greenwood CE, 1996, BEHAV NEUROSCI, V110, P451, DOI 10.1037/0735-7044.110.3.451
   GREENWOOD CE, 1990, BEHAV NEURAL BIOL, V53, P74, DOI 10.1016/0163-1047(90)90831-P
   Greenwood CE, 2005, NEUROBIOL AGING, V26, pS42, DOI 10.1016/j.neurobiolaging.2005.08.017
   Hanley AJG, 2005, CIRCULATION, V112, P3713, DOI 10.1161/CIRCULATIONAHA.105.559633
   Hendrickx H, 2005, NEUROBIOL AGING, V26, pS1, DOI 10.1016/j.neurobiolaging.2005.10.005
   Johnson PM, 2010, NAT NEUROSCI, V13, P635, DOI 10.1038/nn.2519
   Kawai N, 1997, STROKE, V28, P149, DOI 10.1161/01.STR.28.1.149
   McNeill AM, 2005, DIABETES CARE, V28, P385, DOI 10.2337/diacare.28.2.385
   McNeilly AD, 2011, BEHAV BRAIN RES, V217, P134, DOI 10.1016/j.bbr.2010.10.017
   Molteni R, 2002, NEUROSCIENCE, V112, P803, DOI 10.1016/S0306-4522(02)00123-9
   MONTOYA CP, 1991, J NEUROSCI METH, V36, P219, DOI 10.1016/0165-0270(91)90048-5
   Paxinos G., 1998, RAT BRAIN STEROTAXIC, VFourth
   Pialoux V, 2009, HYPERTENSION, V54, P1014, DOI 10.1161/HYPERTENSIONAHA.109.138917
   Ploughman M, 2007, EUR J NEUROSCI, V25, P3453, DOI 10.1111/j.1460-9568.2007.05591.x
   Ploughman M, 2009, STROKE, V40, P1490, DOI 10.1161/STROKEAHA.108.531806
   SAMPEY BP, OBESITY IN PRESS
   Spencer SJ, 2006, J CEREBR BLOOD F MET, V26, P456, DOI 10.1038/sj.jcbfm.9600206
   Wang CY, 2009, SCI SIGNAL, V2, DOI 10.1126/scisignal.2000143
   Welsh JA, 2010, JAMA-J AM MED ASSOC, V303, P1490, DOI 10.1001/jama.2010.449
   Windle V, 2006, EXP NEUROL, V201, P324, DOI 10.1016/j.expneurol.2006.04.012
   Winocur G, 1999, BEHAV BRAIN RES, V101, P153, DOI 10.1016/S0166-4328(98)00147-8
   Wu A, 2003, NEUROSCIENCE, V119, P365, DOI 10.1016/S0306-4522(03)00154-4
   Wu AG, 2004, EUR J NEUROSCI, V19, P1699, DOI 10.1111/j.1460-9568.2004.03246.x
   Zhang XC, 2005, EXP NEUROL, V191, P318, DOI 10.1016/j.expneurol.2004.10.011
NR 31
TC 65
Z9 74
U1 0
U2 14
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
EI 1873-7544
J9 NEUROSCIENCE
JI Neuroscience
PD MAY 19
PY 2011
VL 182
BP 82
EP 87
DI 10.1016/j.neuroscience.2011.03.028
PG 6
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 762FP
UT WOS:000290460600007
PM 21435380
DA 2025-06-11
ER

PT J
AU Senturk, O
   Kocaman, O
   Hulagu, S
   Sahin, T
   Aygun, C
   Konduk, T
   Celebi, A
AF Senturk, O.
   Kocaman, O.
   Hulagu, S.
   Sahin, T.
   Aygun, C.
   Konduk, T.
   Celebi, A.
TI Endothelial dysfunction in Turkish patients with non-alcoholic fatty
   liver disease
SO INTERNAL MEDICINE JOURNAL
LA English
DT Article
DE cardiovascular complication; endothelial-dependent dilatation;
   endothelial-independent dilatation; non-alcoholic fatty liver disease
ID CORONARY-HEART-DISEASE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; RISK-FACTORS; CARDIOVASCULAR-DISEASE; NITRIC-OXIDE;
   STEATOHEPATITIS; GLUCOSE; ARTERY
AB Background: The components of the metabolic syndrome are closely related with endothelial dysfunction, which is a pathophysiological issue of cardiovascular diseases. Non-alcoholic fatty liver disease (NAFLD) is considered as one of the components of the metabolic syndrome. The aim of this study was to evaluate the endothelial-dependent dilatation (EDD) and endothelial-independent dilatation (EID) of the brachial artery in NAFLD.
   Methods: Fifteen non-alcoholic steatohepatitis (NASH), 17 patients with simple steatosis and 16 healthy subjects formed the study group. Non-alcoholic fatty liver disease group was composed of patients admitted to the gastroenterology outpatient clinic because of increased liver enzymes. Endothelial functions of the brachial artery were evaluated by vascular ultrasound. EDD was assessed by establishing reactive hyperaemia, and EID was determined by using sublingual nitrate.
   Results: No statistical difference for the basal diameter of brachial artery was found between the groups (P = 0.49). The values for EDD and EID were significantly different across all three groups (P < 0.0001 and P < 0.0001, respectively). EDD and EID were significantly lower in NASH compared with simple steatosis (P = 0.01 and P < 0.01, respectively). However, there was no statistical significance for EDD and EID in simple steatosis groups compared with controls (P = 0.58 and P = 0.98, respectively).
   Conclusions: Our study showed that patients with NASH had significantly worse endothelial dysfunction compared with patients with simple steatosis and healthy subjects. The treatment strategies with ameliorative effects for endothelial dysfunction might be effective for delaying the development of cardiovascular complications in NAFLD.
C1 [Senturk, O.; Kocaman, O.; Hulagu, S.; Aygun, C.; Konduk, T.; Celebi, A.] Kocaeli Univ, Div Gastroenterol, Fac Med, TR-41380 Kocaeli, Turkey.
   [Sahin, T.] Kocaeli Univ, Fac Med, Dept Cardiol, TR-41380 Kocaeli, Turkey.
C3 Kocaeli University; Kocaeli University
RP Kocaman, O (corresponding author), Kocaeli Univ, Div Gastroenterol, Fac Med, TR-41380 Kocaeli, Turkey.
EM drokocaman@hotmail.com
RI Şahin, Tuğçe/G-2962-2018; Konduk, Buğra/AAH-1079-2020
OI KONDUK, BUGRA/0000-0002-9138-9984; KOCAMAN, ORHAN/0009-0005-7866-3626;
   Senturk, Omer/0000-0003-2342-9136
CR ANDERSON EA, 1989, CIRCULATION, V79, P93, DOI 10.1161/01.CIR.79.1.93
   [Anonymous], 2001, J AM MED ASS
   Arcaro G, 2002, CIRCULATION, V105, P576, DOI 10.1161/hc0502.103333
   Aygun C, 2006, EUR J GASTROEN HEPAT, V18, P175, DOI 10.1097/00042737-200602000-00010
   Bookman ID, 2006, LIVER INT, V26, P566, DOI 10.1111/j.1478-3231.2006.01256.x
   Brunt EM, 1999, AM J GASTROENTEROL, V94, P2467, DOI 10.1111/j.1572-0241.1999.01377.x
   Bugianesi E, 2004, DIGEST LIVER DIS, V36, P165, DOI 10.1016/j.dld.2003.12.008
   Bugiardini R, 2004, CIRCULATION, V109, P2518, DOI 10.1161/01.CIR.0000128208.22378.E3
   CELERMAJER DS, 1992, LANCET, V340, P1111, DOI 10.1016/0140-6736(92)93147-F
   Corretti MC, 2002, J AM COLL CARDIOL, V39, P257, DOI 10.1016/S0735-1097(01)01746-6
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   Dijkhorst-Oei LT, 1999, J CARDIOVASC PHARM, V33, P420, DOI 10.1097/00005344-199903000-00012
   Drexler H, 1999, J MOL CELL CARDIOL, V31, P51, DOI 10.1006/jmcc.1998.0843
   Falck-Ytter Y, 2001, SEMIN LIVER DIS, V21, P17, DOI 10.1055/s-2001-12926
   Federico A, 2006, DIGEST LIVER DIS, V38, P789, DOI 10.1016/j.dld.2006.04.009
   Festi D, 2004, Obes Rev, V5, P27, DOI 10.1111/j.1467-789X.2004.00126.x
   Fonseca V, 2004, ENDOCR REV, V25, P153, DOI 10.1210/er.2002-0034
   Fonseca VA, 2000, ANN INTERN MED, V133, P154, DOI 10.7326/0003-4819-133-2-200007180-00015
   Galli A, 2005, HEPATOLOGY, V41, P1074, DOI 10.1002/hep.20683
   James OFW, 1998, J HEPATOL, V29, P495, DOI 10.1016/S0168-8278(98)80073-1
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   Loguercio C, 2003, FREE RADICAL BIO MED, V34, P1, DOI 10.1016/S0891-5849(02)01167-X
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Mancia G, 2003, J HYPERTENS, V21, P1011, DOI 10.1097/01.hjh.0000059051.65882.32
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mokdad AH, 2003, JAMA-J AM MED ASSOC, V289, P76, DOI 10.1001/jama.289.1.76
   Pessayre D, 2005, J HEPATOL, V42, P928, DOI 10.1016/j.jhep.2005.03.004
   Sanyal Arun J, 2002, Gastroenterology, V123, P1705, DOI 10.1053/gast.2002.36572
   Sarkar K, 2006, CURR OPIN CARDIOL, V21, P316, DOI 10.1097/01.hco.0000231401.87232.71
   SORENSEN KE, 1995, BRIT HEART J, V74, P247
   Steinberg HO, 2002, DIABETOLOGIA, V45, P623, DOI 10.1007/s00125-002-0800-2
   Thomas GN, 2004, ARTERIOSCL THROM VAS, V24, P739, DOI 10.1161/01.ATV.0000118015.26978.07
   Van Guilder GP, 2006, OBESITY, V14, P2127, DOI 10.1038/oby.2006.248
   Villanova N, 2005, HEPATOLOGY, V42, P473, DOI 10.1002/hep.20781
   Vincent MA, 2003, AM J PHYSIOL-ENDOC M, V285, pE123, DOI 10.1152/ajpendo.00021.2003
   Yang ZH, 2006, CLIN MED RES, V4, P53, DOI 10.3121/cmr.4.1.53
   Younossi ZM, 1998, MODERN PATHOL, V11, P560
   Zeng GY, 1996, J CLIN INVEST, V98, P894, DOI 10.1172/JCI118871
NR 38
TC 37
Z9 41
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1444-0903
EI 1445-5994
J9 INTERN MED J
JI Intern. Med. J.
PD MAR
PY 2008
VL 38
IS 3
BP 183
EP 189
DI 10.1111/j.1445-5994.2007.01481.x
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 263ZK
UT WOS:000253254800007
PM 17725609
DA 2025-06-11
ER

PT J
AU Redline, S
   Storfer-Isser, A
   Rosen, CL
   Johnson, NL
   Kirchner, HL
   Emancipator, J
   Kibler, AM
AF Redline, Susan
   Storfer-Isser, Amy
   Rosen, Carol L.
   Johnson, Nathan L.
   Kirchner, H. Lester
   Emancipator, Judith
   Kibler, Anna Marie
TI Association between metabolic syndrome and sleep-disordered breathing in
   adolescents
SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
LA English
DT Article
DE sleep apnea; metabolic syndrome; obesity
ID POSITIVE AIRWAY PRESSURE; 3RD NATIONAL-HEALTH; NUTRITION EXAMINATION
   SURVEY; INSULIN-RESISTANCE; FOLLOW-UP; GLUCOSE-TOLERANCE;
   DIABETES-MELLITUS; PUBERTAL CHANGES; RISK-FACTORS; CHILDREN
AB Rationale: Metabolic syndrome (MetS) affects 4 to 10% of adolescents. Risk factors include overweight, male sex, and Hispanic ethnicity. Although sleep-disordered breathing (SDB) has been implicated as a risk factor for MetS in adults, its association with SDB in adolescents is unknown.
   Objectives: To define the association of SDB with MetS in adolescents.
   Methods: Standardized measurements of SDB, anthropometry and bioassays, were made in 270 adolescents, aged 13.6 +/- 0.7 years. MetS was identified if threshold levels were exceeded in three of five areas: waist circumference, blood pressure, triglyceride level, high-density lipoprotein cholesterol level, and glucose levels.
   Measurements and Main Results: Although 70% of children with SDB (apnea-hypopnea index >= 5) were overweight and 59% had MetS, 16% of children without SDB had MetS. Twenty-five percent of those with MetS had SDB. After adjusting for age, race, sex, and preterm status, children with SDB had a 6.49 (95% confidence interval, 2.52, 16.70) increased odds of MetS compared with children without SDB. Indices of SDB stress associated with MetS included respiratory event frequency, degree of oxygen desaturation, and sleep efficiency. Analyses of individual metabolic parameters showed that, after adjustment for body mass index, SDB was associated with systolic and diastolic blood pressure, low-density lipoprotein cholesterol, and fasting insulin levels.
   Conclusions: A majority of adolescents with SDB are overweight and meet criteria for MetS. The close association between MetS and SDB and their putative interacting pathophysiologies suggests a need to develop screening, prevention, and treatment strategies for both disorders in high-risk, overweight adolescents.
C1 Case Western Reserve Univ, Rainbow Babies & Childrens Hosp, Dept Pediat, Cleveland, OH 44106 USA.
   Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA.
C3 University Hospitals of Cleveland; Rainbow Babies & Children's Hospital;
   University System of Ohio; Case Western Reserve University; Case Western
   Reserve University Hospital; University System of Ohio; Case Western
   Reserve University
RP Redline, S (corresponding author), Case Western Reserve Univ, Rainbow Babies & Childrens Hosp, Dept Pediat, 11100 Euclid Ave, Cleveland, OH 44106 USA.
EM susan.redline@case.edu
FU NCI NIH HHS [1 U54CA116867] Funding Source: Medline; NCRR NIH HHS [M01
   RR00080] Funding Source: Medline; NHLBI NIH HHS [HL07567, HL60957, K23
   HL04426] Funding Source: Medline; NINR NIH HHS [R01 NR02707] Funding
   Source: Medline
CR Al-Delaimy WK, 2002, AM J EPIDEMIOL, V155, P387, DOI 10.1093/aje/155.5.387
   [Anonymous], 2000, ADV DATA, V314, P1
   [Anonymous], 2001, DIABETES CARE
   Babu AR, 2005, ARCH INTERN MED, V165, P447, DOI 10.1001/archinte.165.4.447
   Berenson GS, 1998, NEW ENGL J MED, V338, P1650, DOI 10.1056/NEJM199806043382302
   BONNET MH, 1992, SLEEP, V15, P526
   Bonora E, 2000, DIABETES CARE, V23, P57, DOI 10.2337/diacare.23.1.57
   Cook S, 2003, ARCH PEDIAT ADOL MED, V157, P821, DOI 10.1001/archpedi.157.8.821
   Corbo Giuseppe M., 2001, Pediatrics, V108, P1149, DOI 10.1542/peds.108.5.1149
   CUSHMAN M, 1995, CLIN CHEM, V41, P264
   de Ferranti SD, 2004, CIRCULATION, V110, P2494, DOI 10.1161/01.CIR.0000145117.40114.C7
   de la Eva RC, 2002, J PEDIATR-US, V140, P654, DOI 10.1067/mpd.2002.123765
   Dyugovskaya L, 2002, AM J RESP CRIT CARE, V165, P934, DOI 10.1164/ajrccm.165.7.2104126
   Elmasry A, 2000, J INTERN MED, V248, P13, DOI 10.1046/j.1365-2796.2000.00683.x
   Faux MD, 2004, SLEEP, V27, P1113, DOI 10.1093/sleep/27.6.1113
   Fernández JR, 2004, J PEDIATR-US, V145, P439, DOI 10.1016/j.jpeds.2004.06.044
   FREEDMAN DS, 1985, JAMA-J AM MED ASSOC, V254, P515, DOI 10.1001/jama.254.4.515
   Gottlieb DJ, 2005, ARCH INTERN MED, V165, P863, DOI 10.1001/archinte.165.8.863
   Gozal D, 2002, SLEEP, V25, P59, DOI 10.1093/sleep/25.1.59
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Harsch IA, 2004, AM J RESP CRIT CARE, V169, P156, DOI 10.1164/rccm.200302-206OC
   Hotamisligil GS, 2003, INT J OBESITY, V27, pS53, DOI 10.1038/sj.ijo.0802502
   Ip MSM, 2000, AM J RESP CRIT CARE, V162, P2166, DOI 10.1164/ajrccm.162.6.2002126
   Kaditis AG, 2005, PEDIATR PULM, V40, P515, DOI 10.1002/ppul.20306
   Kimm SYS, 2002, PEDIATRICS, V110, DOI 10.1542/peds.110.5.e54
   KUMP K, 1994, AM J RESP CRIT CARE, V150, P735, DOI 10.1164/ajrccm.150.3.8087345
   Larkin EK, 2005, CIRCULATION, V111, P1978, DOI 10.1161/01.CIR.0000161819.76138.5E
   Marin JM, 2005, LANCET, V365, P1046, DOI 10.1016/S0140-6736(05)71141-7
   MARSHALL WA, 1969, ARCH DIS CHILD, V44, P291, DOI 10.1136/adc.44.235.291
   MARSHALL WA, 1970, ARCH DIS CHILD, V45, P13, DOI 10.1136/adc.45.239.13
   Morrison JA, 2005, PEDIATRICS, V116, P1178, DOI 10.1542/peds.2004-2358
   MUST A, 1992, NEW ENGL J MED, V327, P1350, DOI 10.1056/NEJM199211053271904
   Natl High Blood Pressure Educ Prog, 2004, PEDIATRICS, V114, P555
   Ogden CL, 2002, JAMA-J AM MED ASSOC, V288, P1728, DOI 10.1001/jama.288.14.1728
   Ogden CL, 2006, JAMA-J AM MED ASSOC, V295, P1549, DOI 10.1001/jama.295.13.1549
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   PARKER DJP, 1992, J EPIDEMIOL COMMUN H, V46, P8, DOI 10.1136/jech.46.1.8
   Punjabi NM, 2004, AM J EPIDEMIOL, V160, P521, DOI 10.1093/aje/kwh261
   Rechtschaffen Allan, 1968, MANUAL STANDARDIZED
   Redline S, 1998, SLEEP, V21, P759
   Rosen CL, 2003, J PEDIATR-US, V142, P383, DOI 10.1067/mpd.2003.28
   Rosenbaum M, 1988, Adv Pediatr, V35, P73
   Shahar E, 2001, AM J RESP CRIT CARE, V163, P19, DOI 10.1164/ajrccm.163.1.2001008
   Sinha R, 2002, NEW ENGL J MED, V346, P802, DOI 10.1056/NEJMoa012578
   Slyper AH, 1998, PEDIATRICS, V102, DOI 10.1542/peds.102.1.e4
   Spilsbury JC, 2004, ARCH PEDIAT ADOL MED, V158, P988, DOI 10.1001/archpedi.158.10.988
   Srinivasan SR, 2002, DIABETES, V51, P204, DOI 10.2337/diabetes.51.1.204
   Sulit L, 2006, SLEEP, V29, P777, DOI 10.1093/sleep/29.6.777
   Tauman R, 2005, PEDIATRICS, V116, pE66, DOI 10.1542/peds.2004-2527
   Tauman R, 2004, PEDIATRICS, V113, pE564, DOI 10.1542/peds.113.6.e564
   Troiano RP, 1998, PEDIATRICS, V101, P497
   *US BUR CENS, 1970, CENS CD NEIGHB CHANG
   Van Cauter E, 1998, SLEEP, V21, P553
   Waters KA, 2006, AM J RESP CRIT CARE, V174, P455, DOI 10.1164/rccm.200401-110OC
   Weiss R, 2004, NEW ENGL J MED, V350, P2362, DOI 10.1056/NEJMoa031049
   Wing YK, 2003, ARCH DIS CHILD, V88, P1043, DOI 10.1136/adc.88.12.1043
   YOUNG T, 1993, NEW ENGL J MED, V328, P1230, DOI 10.1056/NEJM199304293281704
NR 57
TC 213
Z9 228
U1 0
U2 5
PU AMER THORACIC SOC
PI NEW YORK
PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA
SN 1073-449X
EI 1535-4970
J9 AM J RESP CRIT CARE
JI Am. J. Respir. Crit. Care Med.
PD AUG 15
PY 2007
VL 176
IS 4
BP 401
EP 408
DI 10.1164/rccm.200703-375OC
PG 8
WC Critical Care Medicine; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Respiratory System
GA 199FR
UT WOS:000248682100015
PM 17541017
OA Green Published
DA 2025-06-11
ER

PT J
AU Adams-Huet, B
   Jialal, I
AF Adams-Huet, Beverley
   Jialal, Ishwarlal
TI An Increasing Triglyceride-Glucose Index Is Associated with a
   Pro-Inflammatory and Pro-Oxidant Phenotype
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE insulin resistance; triglyceride-glucose index; inflammation; metabolic
   syndrome
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; ADIPOSE-TISSUE; SURROGATE;
   CHEMERIN; PRODUCT; DISEASE
AB Background/Objectives: Insulin resistance is crucial in the pathogenesis of Metabolic Syndrome (MetS), type 2 diabetes mellitus (T2DM) and premature atherosclerotic cardiovascular disease (ASCVD). The triglyceride-glucose index (TyG index), a validated measure of insulin resistance, also predicts MetS, T2DM, the severity of albuminuria and ASCVD. There are scant data providing mechanistic insights into these sequalae. Accordingly, we investigated the relationship between the TyG index and biomarkers of inflammation, oxidative stress, free fatty acid (FFA) levels and adipokine dysregulation in a cohort comprising both controls and patients with nascent MetS. Methods: Participants (n = 102) included 59 patients with MetS and 43 controls. People with diabetes, ASCVD, smoking and macro-inflammation were excluded. Fasting blood was obtained for both plasma and monocyte isolation. Results: Receiver Operating Characteristic (ROC) curve analysis revealed that the TyG index was an excellent predictor of MetS with an area under the curve of 0.87, and it correlated with both hepatic and adipose tissue insulin resistance. Both serum RBP-4 levels and non-HDL cholesterol increased significantly over tertiles of the TyG index. Based on the TyG index tertiles and/or correlations, oxidized LDL, nitrotyrosine, C-reactive protein, endotoxin, chemerin, interleukin-6 levels and monocyte toll-like receptor (TLR)-4 and TLR-2 and their cellular signaling were significantly associated with the TyG index. Conclusions: Increased non-HDL-C and, most importantly, a pro-inflammatory and pro-oxidant state could be advanced as potential mechanisms explaining the increased risk for T2DM and ASCVD with an increasing TyG index.
C1 [Adams-Huet, Beverley] UT Southwestern Med Ctr, Dallas, TX 75235 USA.
   [Jialal, Ishwarlal] Univ Calif Davis, Sch Med, 2616 Hepworth Dr, Davis, CA 95618 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center Dallas; University of California System; University of California
   Davis
RP Jialal, I (corresponding author), Univ Calif Davis, Sch Med, 2616 Hepworth Dr, Davis, CA 95618 USA.
EM huet@digitrain.com; kjialal@gmail.com
OI jialal, kenny/0000-0001-9113-2604
FX We thank the volunteers for participating in our study.
CR Adams-Huet B, 2024, J CLIN LIPIDOL, V18, pe518, DOI 10.1016/j.jacl.2024.04.130
   Adams-Huet B, 2014, METAB SYNDR RELAT D, V12, P503, DOI 10.1089/met.2014.0092
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alemany M, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25042251
   [Anonymous], 2000, WILEY PS TX, DOI 10.1002/0471722146
   Bobbert T, 2015, CLIN ENDOCRINOL, V82, P838, DOI 10.1111/cen.12707
   Bremer AA, 2011, J CLIN ENDOCR METAB, V96, pE1782, DOI 10.1210/jc.2011-1577
   D'Elia L, 2024, J CLIN ENDOCR METAB, V110, pe470, DOI 10.1210/clinem/dgae170
   DeFronzo RA, 2010, DIABETOLOGIA, V53, P1270, DOI 10.1007/s00125-010-1684-1
   Falck-Hansen M, 2013, INT J MOL SCI, V14, P14008, DOI 10.3390/ijms140714008
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Guerrero-Romero F, 2010, J CLIN ENDOCR METAB, V95, P3347, DOI 10.1210/jc.2010-0288
   Jialal I, 2016, DIABETES VASC DIS RE, V13, P93, DOI 10.1177/1479164115607829
   Jialal I, 2013, J CLIN ENDOCR METAB, V98, pE514, DOI 10.1210/jc.2012-3673
   Jialal I, 2012, J CLIN ENDOCR METAB, V97, pE1844, DOI 10.1210/jc.2012-2498
   Jialal I, 2012, DIABETES CARE, V35, P900, DOI 10.2337/dc11-2375
   Vasques ACJ, 2011, DIABETES RES CLIN PR, V93, pE98, DOI 10.1016/j.diabres.2011.05.030
   Li R, 2018, J DIABETES INVEST, V9, P411, DOI 10.1111/jdi.12708
   Libby P, 2021, CARDIOVASC RES, V117, P2525, DOI 10.1093/cvr/cvab303
   Lopez-Jaramillo P, 2023, LANCET HEALTH LONGEV, V4, pE23, DOI 10.1016/S2666-7568(22)00247-1
   Lopez-Yus M, 2024, CELLS-BASEL, V13, DOI 10.3390/cells13050380
   Martemucci G, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12122091
   Moon JH, 2023, ENDOCRINOL METAB, V38, P406, DOI 10.3803/EnM.2023.1703
   Nabipoorashra SA, 2022, NUTR METAB CARDIOVAS, V32, P2677, DOI 10.1016/j.numecd.2022.07.024
   Park HM, 2021, DIABETES RES CLIN PR, V180, DOI 10.1016/j.diabres.2021.109042
   Raja V, 2023, ATHEROSCLEROSIS, V383, DOI 10.1016/j.atherosclerosis.2023.117312
   REAVEN GM, 1993, ANNU REV MED, V44, P121, DOI 10.1146/annurev.med.44.1.121
   Reddy P, 2019, CLIN CHIM ACTA, V496, P35, DOI 10.1016/j.cca.2019.06.019
   Shi H, 2006, J CLIN INVEST, V116, P3015, DOI 10.1172/JCI28898
   Simental-Mendia Luis E., 2008, Metabolic Syndrome and Related Disorders, V6, P299, DOI 10.1089/met.2008.0034
   Son DH, 2022, NUTR METAB CARDIOVAS, V32, P596, DOI 10.1016/j.numecd.2021.11.017
   Tan LB, 2023, NUTRIENTS, V15, DOI 10.3390/nu15132878
   Tao LC, 2022, CARDIOVASC DIABETOL, V21, DOI 10.1186/s12933-022-01511-x
   Wang ZX, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1215055
   Welsh C, 2019, CIRCULATION, V140, P542, DOI 10.1161/CIRCULATIONAHA.119.041149
   Xiao SJ, 2023, MEDIAT INFLAMM, V2023, DOI 10.1155/2023/1966680
NR 36
TC 8
Z9 8
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUL
PY 2024
VL 13
IS 13
AR 3941
DI 10.3390/jcm13133941
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA YO0V8
UT WOS:001269319900001
PM 38999506
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Li, PF
   Lin, YJ
   Liang, YJ
   Chen, WL
AF Li, Peng-Fei
   Lin, Yu-Jen
   Liang, Yao-Jen
   Chen, Wei-Liang
TI The Association between Human Epididymis Secretory Protein 4 and
   Metabolic Syndrome
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE human epididymis protein 4; 2 metabolic syndrome components; 3
   carcinogenesis
ID OVARIAN MALIGNANCY ALGORITHM; OXIDATIVE STRESS; SERUM HE-4; CANCER;
   RISK; INFLAMMATION; BIOMARKER; DISEASE; CA125; WOMEN
AB Individuals with metabolic syndrome (MetS) are known to have an increased risk of carcinogenesis. Human epididymis protein 4 (HE4) is a tumor marker and prognostic factor for epithelial ovarian carcinoma (EOC) patients. However, no studies have evaluated the association between MetS and HE4 levels. This study aimed to evaluate the relationship between HE4 levels and MetS in the National Health and Nutrition Examination Survey (NHANES 2001-2002). This cross-sectional analysis assessed all five components of MetS and HE4 levels in 2104 females (age >= 20 years) from the NHANES dataset. MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATPIII) criteria. The analysis indicated MetS in 593 individuals, and the beta coefficient of their HE4 levels was 0.097 (95% CIs, 0.028-0.166, p = 0.006). Specifically, the beta coefficients of the HE4 levels of participants with 1, 2, 3, and >= 4 features of MetS were 0.072 (95% confidence interval (CI): -0.015-0.159), 0.125 (95% CI: 0.030-0.220), 0.161 (95% CI: 0.053-0.270), and 0.242 (95% CI: 0.117-0.368), respectively, and all p values were p-value for the trend was <0.001. There was a significant association between the presence of MetS and HE4 levels. There were positive relationships between HE4 levels and an increased number of MetS components (with 1, 2, 3, and >= 4 features of MetS, all p values <0.001). Among the MetS components, low high-density lipoprotein levels and high triglyceride levels were independently associated with HE4 levels.
C1 [Li, Peng-Fei] Triserv Gen Hosp, Natl Def Med Sch, Div Endocrinol & Metab, Dept Internal Med, Taipei 114, Taiwan.
   [Li, Peng-Fei] Fu Jen Catholic Univ, Grad Inst Appl Sci & Engn, New Taipei 242, Taiwan.
   [Lin, Yu-Jen; Chen, Wei-Liang] Triserv Gen Hosp, Div Family Med, Dept Family & Community Med, Taipei 114, Taiwan.
   [Lin, Yu-Jen; Chen, Wei-Liang] Natl Def Med Ctr, Sch Med, Taipei 114, Taiwan.
   [Liang, Yao-Jen] Fu Jen Catholic Univ, Grad Inst Appl Sci & Engn, New Taipei 242, Taiwan.
   [Liang, Yao-Jen] Fu Jen Catholic Univ, Dept & Inst Life Sci, New Taipei 242, Taiwan.
   [Chen, Wei-Liang] Triserv Gen Hosp, Div Geriatr Med, Dept Family & Community Med, Taipei 114, Taiwan.
   [Chen, Wei-Liang] Natl Def Med Ctr, Dept Biochem, Taipei 114, Taiwan.
C3 National Defense Medical Center; Tri-Service General Hospital; Fu Jen
   Catholic University; Tri-Service General Hospital; National Defense
   Medical Center; Fu Jen Catholic University; Fu Jen Catholic University;
   Tri-Service General Hospital; National Defense Medical Center
RP Chen, WL (corresponding author), Triserv Gen Hosp, Div Family Med, Dept Family & Community Med, Taipei 114, Taiwan.; Chen, WL (corresponding author), Natl Def Med Ctr, Sch Med, Taipei 114, Taiwan.; Chen, WL (corresponding author), Triserv Gen Hosp, Div Geriatr Med, Dept Family & Community Med, Taipei 114, Taiwan.; Chen, WL (corresponding author), Natl Def Med Ctr, Dept Biochem, Taipei 114, Taiwan.
EM milkfly198383@gmail.com; ronyowei@yahoo.com.tw; yjl@mail.fju.edu.tw;
   weiliang0508@gmail.com
RI Li, Jenny/GSD-3780-2022; Li, Pengfei/AFW-1229-2022
OI Li, Peng-Fei/0000-0002-3044-7976; LIN, YU JEN/0000-0001-5720-0458; Chen,
   Wei-liang/0000-0003-0784-230X
CR Bene Z, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.592184
   Bjorge T, 2011, INT J EPIDEMIOL, V40, P1667, DOI 10.1093/ije/dyr130
   Bolstad N, 2012, TUMOR BIOL, V33, P141, DOI 10.1007/s13277-011-0256-4
   Bovolini A, 2021, INT J SPORTS MED, V42, P199, DOI 10.1055/a-1263-0898
   Carrier A, 2017, ANTIOXID REDOX SIGN, V26, P429, DOI 10.1089/ars.2016.6929
   Chang XH, 2011, INT J GYNECOL CANCER, V21, P852, DOI 10.1097/IGC.0b013e31821a3726
   Chen YM, 2016, LIPIDS HEALTH DIS, V15, DOI 10.1186/s12944-016-0256-x
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cowey S, 2006, AM J PATHOL, V169, P1505, DOI 10.2353/ajpath.2006.051090
   Cramer DW, 2021, GYNECOL ONCOL, V161, P282, DOI 10.1016/j.ygyno.2021.01.011
   De Nardo D, 2014, NAT IMMUNOL, V15, P152, DOI 10.1038/ni.2784
   De Rosa S, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00002
   Du R, 2017, J DIABETES, V9, P1040, DOI 10.1111/1753-0407.12523
   Esposito K, 2012, DIABETES CARE, V35, P2402, DOI 10.2337/dc12-0336
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   FEINGOLD KR, 1992, ENDOCRINOLOGY, V130, P10, DOI 10.1210/en.130.1.10
   Galgano MT, 2006, MODERN PATHOL, V19, P847, DOI 10.1038/modpathol.3800612
   Gasiorowska E, 2019, DIS MARKERS, V2019, DOI 10.1155/2019/3890906
   Hertlein L, 2012, CLIN CHEM LAB MED, V50, P2181, DOI 10.1515/cclm-2012-0097
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Huang Y, 2020, LAB MED, V51, P169, DOI 10.1093/labmed/lmz041
   Jia LT, 2016, CLIN TRANSL ONCOL, V18, P233, DOI 10.1007/s12094-015-1365-0
   Kim KN, 2011, J KOREAN MED SCI, V26, P759, DOI 10.3346/jkms.2011.26.6.759
   Lakshmanan M, 2019, INDIAN J CANCER, V56, P216, DOI 10.4103/ijc.IJC_305_18
   Lee S, 2017, J OBSTET GYNAECOL RE, V43, P220, DOI 10.1111/jog.13181
   Macpherson ME, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-45861-1
   Michels KA, 2019, GYNECOL ONCOL, V155, P294, DOI 10.1016/j.ygyno.2019.08.032
   Mohammadi M, 2017, REP BIOCHEM MOL BIOL, V6, P74
   Moore RG, 2010, AM J OBSTET GYNECOL, V203, DOI 10.1016/j.ajog.2010.03.043
   Puente D, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-025365
   Qu WL, 2016, EXPERT REV MOL DIAGN, V16, P1271, DOI 10.1080/14737159.2016.1251317
   Reuter S, 2010, FREE RADICAL BIO MED, V49, P1603, DOI 10.1016/j.freeradbiomed.2010.09.006
   Romagnolo C, 2016, GYNECOL ONCOL, V141, P303, DOI 10.1016/j.ygyno.2016.01.016
   Seyfried TN, 2014, CARCINOGENESIS, V35, P515, DOI 10.1093/carcin/bgt480
   Speeckaert MM, 2013, ADV CLIN CHEM, V59, P1, DOI 10.1016/B978-0-12-405211-6.00001-2
   Tian YP, 2015, J OVARIAN RES, V8, DOI 10.1186/s13048-015-0201-z
   Unterscheider J, 2012, AM J OBSTET GYNECOL, V206, pS309, DOI 10.1016/j.ajog.2011.12.028
   Wang LS, 2018, INT UROL NEPHROL, V50, P2043, DOI 10.1007/s11255-018-1930-x
   Welty FK, 2016, TRANSL RES, V167, P257, DOI 10.1016/j.trsl.2015.06.017
   Yanaranop M, 2017, GYNECOL OBSTET INVES, V82, P47, DOI 10.1159/000446238
   Yuan TF, 2017, LAB MED, V48, P238, DOI 10.1093/labmed/lmx036
   Zhang Miaomiao, 2019, Biomed Res Int, V2019, P4831459, DOI 10.1155/2019/4831459
   Zipf George, 2013, Vital Health Stat 1, P1
NR 43
TC 1
Z9 1
U1 0
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAY
PY 2022
VL 11
IS 9
AR 2362
DI 10.3390/jcm11092362
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 1G8PX
UT WOS:000796113000001
PM 35566488
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Al Akl, NS
   Khalifa, O
   Errafii, K
   Arredouani, A
AF Al Akl, Neyla S.
   Khalifa, Olfa
   Errafii, Khaoula
   Arredouani, Abdelilah
TI Association of dyslipidemia, diabetes and metabolic syndrome with serum
   ferritin levels: a middle eastern population-based cross-sectional study
SO SCIENTIFIC REPORTS
LA English
DT Article
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; IRON; RISK; GLUCOSE; HEALTH
AB Elevated serum ferritin (SFer) levels are implicated in many energy metabolism abnormalities. The association between SFer levels and metabolic disorders has not been studied in Middle Eastern populations. We aimed at exploring the association between SFer levels and serum lipids, diabetes determinants, and metabolic syndrome in a sample of Qatari adults. This study used biochemical parameters obtained from 1928 participants from the Qatar Biobank cohort. We utilized adjusted multivariable logistic regression analysis to estimate the odds ratios (ORs) for dyslipidemia, type 2 diabetes, the homeostasis model assessment of insulin resistance (HOMA-IR), and metabolic syndrome (MetS) according to sex-specific SFer quartiles (Q1 to Q4). Results revealed that the ORs for dyslipidemia increased progressively and significantly across the SFer quartiles, up to two folds in Q4 for women (OR 2.47 (1.68-3.62)) and men (OR 2.24 (1.41-3.55)) versus Q1 (OR:1). Exclusively in women, the ORs for IR (HOMA-IR > 3.58) increased significantly in Q4 (OR 1.79 (1.19-2.70)) versus OR 1 in Q1 as did the ORs for diabetes (OR: 2.03 (1.15-3.57) in Q4 versus OR 1 in Q1). We observed the same result when we pooled the participants with prediabetes and diabetes in one group. The OR for MetS also increased significantly across the Sfer Quartiles from OR: 1 in Q1 to 1.92 (1.06-3.02) in Q4 for women and to 2.07 (1.08-3.98) in Q4 in men. Our results suggest the elevated Sfer levels as a potential risk biomarker for dyslipidemia and MetS in adult Qatari men and women, and diabetes and IR in women only.
C1 [Al Akl, Neyla S.; Khalifa, Olfa; Errafii, Khaoula; Arredouani, Abdelilah] Hamad Bin Khalifa Univ HBKU, Qatar Fdn, Diabet Res Ctr, Qatar Biomed Res Inst QBRI, Doha, Qatar.
   [Errafii, Khaoula; Arredouani, Abdelilah] Hamad Bin Khalifa Univ HBKU, Qatar Fdn, Coll Hlth & Life Sci, Doha, Qatar.
C3 Qatar Foundation (QF); Hamad Bin Khalifa University-Qatar; Qatar
   Biomedical Research Institute (QBRI); Qatar Foundation (QF); Hamad Bin
   Khalifa University-Qatar
RP Arredouani, A (corresponding author), Hamad Bin Khalifa Univ HBKU, Qatar Fdn, Diabet Res Ctr, Qatar Biomed Res Inst QBRI, Doha, Qatar.; Arredouani, A (corresponding author), Hamad Bin Khalifa Univ HBKU, Qatar Fdn, Coll Hlth & Life Sci, Doha, Qatar.
EM aarredouani@hbku.edu.qa
RI arredouani, abdelilah/Q-9650-2019
OI Errafii, Khaoula/0000-0003-4744-2431
FU intermural grant from Qatar Biomedical Research Institute
FX The project was funded by intermural grant from Qatar Biomedical
   Research Institute to AA.
CR Abbaspour N, 2014, J RES MED SCI, V19, P164
   Akter S, 2017, J DIABETES INVEST, V8, P462, DOI 10.1111/jdi.12617
   Al Kuwari H, 2015, BMC PUBLIC HEALTH, V15, DOI 10.1186/s12889-015-2522-7
   Al-Thani MH, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2015-009514
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Ali FMH, 2014, POPUL HEALTH METR, V12, DOI 10.1186/1478-7954-12-18
   [Anonymous], 2003, SCREEN TYP 2 DIAB RE
   [Anonymous], 2017, High cholesterol: Overview
   Aregbesola A, 2015, DIABETES-METAB RES, V31, P507, DOI 10.1002/dmrr.2628
   Aydin O, 2014, BIOCHEM MEDICA, V24, P383, DOI 10.11613/BM.2014.041
   Brochu M, 2001, J CLIN ENDOCR METAB, V86, P1020, DOI 10.1210/jc.86.3.1020
   Brudevold R, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003547
   Chen L, 2017, J DIABETES COMPLICAT, V31, P364, DOI 10.1016/j.jdiacomp.2016.06.018
   Cho MR, 2017, MATURITAS, V103, P3, DOI 10.1016/j.maturitas.2017.06.004
   Fernández-Real JM, 2002, DIABETES, V51, P2348, DOI 10.2337/diabetes.51.8.2348
   Forouhi NG, 2007, DIABETOLOGIA, V50, P949, DOI 10.1007/s00125-007-0604-5
   Gowda S, 2009, PAN AFR MED J, V3, P1
   Hämäläinen P, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-114
   Hevi S, 2003, J BIOL CHEM, V278, P31924, DOI 10.1074/jbc.M303081200
   Hostalek Ulrike, 2019, Clin Diabetes Endocrinol, V5, P5, DOI 10.1186/s40842-019-0080-0
   International Diabetes Federation, 2018, MEMB MIDDL E N AFR
   Kharroubi AT, 2015, WORLD J DIABETES, V6, P850, DOI 10.4239/wjd.v6.i6.850
   Ledesma M, 2015, J CLIN ENDOCR METAB, V100, P2081, DOI 10.1210/jc.2014-4409
   Leiva E, 2013, BIOL TRACE ELEM RES, V151, P1, DOI 10.1007/s12011-012-9525-3
   Li J, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0190310
   Ma H, 2018, BRIT J NUTR, V120, P863, DOI 10.1017/S0007114518002167
   Martinez-Martinez Maria D, 2018, Sultan Qaboos Univ Med J, V18, pe291, DOI 10.18295/squmj.2018.18.03.005
   Messner DJ, 2013, DIGEST DIS SCI, V58, P1899, DOI 10.1007/s10620-013-2648-3
   Najafipour H, 2016, J DIABETES METAB DIS, V15, DOI 10.1186/s40200-016-0268-0
   Nakamura K, 2017, EXP CLIN ENDOCR DIAB, V125, P12, DOI 10.1055/s-0042-118175
   Padwal MK, 2015, J CLIN DIAGN RES, V9, pBC11, DOI 10.7860/JCDR/2015/13480.6564
   Parhofer KG, 2019, DTSCH ARZTEBL INT, V116, P825, DOI 10.3238/arztebl.2019.0825
   Parhofer KG, 2015, DIABETES METAB J, V39, P353
   Qatar Biobank, 2017, QAT BIOB ANN REP 201
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   SALONEN JT, 1992, CIRCULATION, V86, P803, DOI 10.1161/01.CIR.86.3.803
   Shahbaz H., 2021, CREATININE CLEARANCE
   Smith DG, 2007, AM J MANAG CARE, V13, pS68
   Younis A, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-016-0466-6
   Zhang WCB, 2021, BIOMED ENVIRON SCI, V34, P623, DOI 10.3967/bes2021.086
NR 40
TC 14
Z9 14
U1 0
U2 5
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 16
PY 2021
VL 11
IS 1
AR 24080
DI 10.1038/s41598-021-03534-y
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA XP8GQ
UT WOS:000731098600004
PM 34916585
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Machin, PA
   Tsonou, E
   Hornigold, DC
   Welch, HCE
AF Machin, Polly A.
   Tsonou, Elpida
   Hornigold, David C.
   Welch, Heidi C. E.
TI Rho Family GTPases and Rho GEFs in Glucose Homeostasis
SO CELLS
LA English
DT Review
DE Rho GTPase; small G protein; Rho GEF; guanine nucleotide exchange
   factor; glucose homeostasis; metabolic syndrome; type 2 diabetes; GLUT4
   glucose transporter; insulin-stimulated glucose uptake;
   glucose-stimulated insulin secretion
ID GUANINE-NUCLEOTIDE-EXCHANGE; ACTIVATED PROTEIN-KINASE; STIMULATED GLUT4
   TRANSLOCATION; CYCLIN D1 EXPRESSION; ACTIN STRESS FIBERS;
   SKELETAL-MUSCLE; INSULIN-RESISTANCE; P21-ACTIVATED KINASE; SIGNALING
   PATHWAY; RAC-ACTIVATION
AB Dysregulation of glucose homeostasis leading to metabolic syndrome and type 2 diabetes is the cause of an increasing world health crisis. New intriguing roles have emerged for Rho family GTPases and their Rho guanine nucleotide exchange factor (GEF) activators in the regulation of glucose homeostasis. This review summates the current knowledge, focusing in particular on the roles of Rho GEFs in the processes of glucose-stimulated insulin secretion by pancreatic beta cells and insulin-stimulated glucose uptake into skeletal muscle and adipose tissues. We discuss the ten Rho GEFs that are known so far to regulate glucose homeostasis, nine of which are in mammals, and one is in yeast. Among the mammalian Rho GEFs, P-Rex1, Vav2, Vav3, Tiam1, Kalirin and Plekhg4 were shown to mediate the insulin-stimulated translocation of the glucose transporter GLUT4 to the plasma membrane and/or insulin-stimulated glucose uptake in skeletal muscle or adipose tissue. The Rho GEFs P-Rex1, Vav2, Tiam1 and beta-PIX were found to control the glucose-stimulated release of insulin by pancreatic beta cells. In vivo studies demonstrated the involvement of the Rho GEFs P-Rex2, Vav2, Vav3 and PDZ-RhoGEF in glucose tolerance and/or insulin sensitivity, with deletion of these GEFs either contributing to the development of metabolic syndrome or protecting from it. This research is in its infancy. Considering that over 80 Rho GEFs exist, it is likely that future research will identify more roles for Rho GEFs in glucose homeostasis.
C1 [Machin, Polly A.; Tsonou, Elpida; Welch, Heidi C. E.] Babraham Inst, Signalling Programme, Babraham Res Campus, Cambridge CB22 3AT, England.
   [Tsonou, Elpida; Hornigold, David C.] AstraZeneca, BioPharmaceut R&D, Biosci Metab Res & Early Dev Cardiovasc Renal & M, Cambridge CB22 3AT, England.
C3 UK Research & Innovation (UKRI); Biotechnology and Biological Sciences
   Research Council (BBSRC); Babraham Institute; AstraZeneca
RP Welch, HCE (corresponding author), Babraham Inst, Signalling Programme, Babraham Res Campus, Cambridge CB22 3AT, England.
EM polly.machin@babraham.ac.uk; elpida.tsonou1@astrazeneca.com;
   David.Hornigold@astrazeneca.com; heidi.welch@babraham.ac.uk
RI Tsonou, Elpida/NGS-6849-2025
OI Machin, Polly/0000-0002-8481-8488
FU Institute Strategic Programme Grant from the BBSRC [BB/P013384/1];
   BBSRC; AstraZeneca-MedImmune
FX This research was funded by Institute Strategic Programme Grant
   BB/P013384/1 from the BBSRC to the Signalling Programme at the Babraham
   Institute. P.A.M. receives a targeted studentship from the BBSRC. E.T.
   received an iCASE studentship from the BBSRC in collaboration with
   AstraZeneca-MedImmune.
CR ABO A, 1991, NATURE, V353, P668, DOI 10.1038/353668a0
   Ahmed S, 2010, SEMIN CELL DEV BIOL, V21, P350, DOI 10.1016/j.semcdb.2009.11.008
   Alam MR, 1997, J BIOL CHEM, V272, P12667, DOI 10.1074/jbc.272.19.12667
   Amano M, 2010, CYTOSKELETON, V67, P545, DOI 10.1002/cm.20472
   Arias-Romero LE, 2008, BIOL CELL, V100, P97, DOI 10.1042/BC20070109
   Asahara S, 2013, DIABETOLOGIA, V56, P1088, DOI 10.1007/s00125-013-2849-5
   Balamatsias D, 2011, J BIOL CHEM, V286, P43229, DOI 10.1074/jbc.M111.306621
   Batista TM, 2020, CELL METAB, V32, P844, DOI 10.1016/j.cmet.2020.08.007
   Bear JE, 1998, J CELL BIOL, V142, P1325, DOI 10.1083/jcb.142.5.1325
   Bento JL, 2008, GENOMICS, V92, P226, DOI 10.1016/j.ygeno.2008.06.004
   Berg J. M., 2002, BIOCHEMISTRY
   Berthold J, 2008, ACTA PHARMACOL SIN, V29, P285, DOI 10.1111/j.1745-7254.2008.00773.x
   Bogan JS, 2012, ANNU REV BIOCHEM, V81, P507, DOI 10.1146/annurev-biochem-060109-094246
   Boissier P, 2014, CELL SIGNAL, V26, P483, DOI 10.1016/j.cellsig.2013.11.034
   Borst SE, 2001, LIFE SCI, V69, P1497, DOI 10.1016/S0024-3205(01)01225-5
   BURBELO PD, 1995, J BIOL CHEM, V270, P29071, DOI 10.1074/jbc.270.49.29071
   Bustelo XR, 2007, BIOESSAYS, V29, P356, DOI 10.1002/bies.20558
   Bustelo Xose R, 2014, Small GTPases, V5, P9, DOI 10.4161/21541248.2014.973757
   Cash JN, 2016, STRUCTURE, V24, P730, DOI 10.1016/j.str.2016.02.022
   Castillo-Lluva S, 2010, NAT CELL BIOL, V12, P1078, DOI 10.1038/ncb2112
   Chahdi A, 2013, J BIOL CHEM, V288, P34019, DOI 10.1074/jbc.M113.480103
   Chang FM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0028587
   Chang L, 2002, P NATL ACAD SCI USA, V99, P12835, DOI 10.1073/pnas.202495599
   Chang YJ, 2015, ELIFE, V4, DOI 10.7554/eLife.06011
   Chiang SH, 2001, NATURE, V410, P944, DOI 10.1038/35073608
   Chiu TT, 2011, CELL SIGNAL, V23, P1546, DOI 10.1016/j.cellsig.2011.05.022
   Chiu TT, 2013, J BIOL CHEM, V288, P17520, DOI 10.1074/jbc.M113.467647
   Chiu TT, 2010, MOL BIOL CELL, V21, P3529, DOI 10.1091/mbc.E10-04-0316
   Cho H, 2001, SCIENCE, V292, P1728, DOI 10.1126/science.292.5522.1728
   Chou MM, 1996, CELL, V85, P573, DOI 10.1016/S0092-8674(00)81257-X
   ChrzanowskaWodnicka M, 1996, J CELL BIOL, V133, P1403, DOI 10.1083/jcb.133.6.1403
   Chun KH, 2012, ENDOCRINOLOGY, V153, P1649, DOI 10.1210/en.2011-1036
   Clayton NS, 2020, FRONT CELL DEV BIOL, V8, DOI 10.3389/fcell.2020.00222
   Das S, 2015, P NATL ACAD SCI USA, V112, pE267, DOI 10.1073/pnas.1409667112
   DEFRONZO RA, 1992, DIABETES CARE, V15, P318, DOI 10.2337/diacare.15.3.318
   Deng SS, 2014, CELL ADHES MIGR, V8, P49, DOI 10.4161/cam.27480
   Disanza A, 2006, NAT CELL BIOL, V8, P1337, DOI 10.1038/ncb1502
   Donald S, 2004, FEBS LETT, V572, P172, DOI 10.1016/j.febslet.2004.06.096
   Donald S, 2008, P NATL ACAD SCI USA, V105, P4483, DOI 10.1073/pnas.0712324105
   Doody GM, 2001, NAT IMMUNOL, V2, P542, DOI 10.1038/88748
   Eden S, 2002, NATURE, V418, P790, DOI 10.1038/nature00859
   Etienne-Manneville S, 2002, NATURE, V420, P629, DOI 10.1038/nature01148
   Facchini FS, 2001, J CLIN ENDOCR METAB, V86, P3574, DOI 10.1210/jc.86.8.3574
   Fine B, 2009, SCIENCE, V325, P1261, DOI 10.1126/science.1173569
   Forget MA, 2002, BIOCHEM J, V361, P243, DOI 10.1042/0264-6021:3610243
   Frost JA, 1996, MOL CELL BIOL, V16, P3707, DOI 10.1128/mcb.16.7.3707
   Frost JA, 1997, EMBO J, V16, P6426, DOI 10.1093/emboj/16.21.6426
   Fukuhara S, 1999, J BIOL CHEM, V274, P5868, DOI 10.1074/jbc.274.9.5868
   Furukawa N, 2005, CELL METAB, V2, P119, DOI 10.1016/j.cmet.2005.06.011
   Gao Y, 2004, P NATL ACAD SCI USA, V101, P7618, DOI 10.1073/pnas.0307512101
   Garcia-Mata R, 2011, NAT REV MOL CELL BIO, V12, P493, DOI 10.1038/nrm3153
   Garofalo RS, 2003, J CLIN INVEST, V112, P197, DOI 10.1172/JCI200316885
   Gray JL, 2020, ANGEW CHEM INT EDIT, V59, P6342, DOI 10.1002/anie.201900585
   Greiner TU, 2009, BMC DEV BIOL, V9, DOI 10.1186/1471-213X-9-2
   Gupta M, 2013, J BIOL CHEM, V288, P14522, DOI 10.1074/jbc.M112.430371
   Gupton SL, 2007, J CELL SCI, V120, P3475, DOI 10.1242/jcs.006049
   Hansel DE, 2001, J HISTOCHEM CYTOCHEM, V49, P833, DOI 10.1177/002215540104900704
   HART MJ, 1991, NATURE, V354, P311, DOI 10.1038/354311a0
   Hawley SA, 2002, DIABETES, V51, P2420, DOI 10.2337/diabetes.51.8.2420
   He L, 2009, CELL, V137, P635, DOI 10.1016/j.cell.2009.03.016
   Henríquez-Olguin C, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-12523-9
   Hernández-Negrete I, 2007, J BIOL CHEM, V282, P23708, DOI 10.1074/jbc.M703771200
   HILL CS, 1995, CELL, V81, P1159, DOI 10.1016/S0092-8674(05)80020-0
   Hinz M, 1999, MOL CELL BIOL, V19, P2690
   Hodakoski C, 2014, P NATL ACAD SCI USA, V111, P155, DOI 10.1073/pnas.1213773111
   Hodge RG, 2016, NAT REV MOL CELL BIO, V17, P496, DOI 10.1038/nrm.2016.67
   Huang SH, 2007, CELL METAB, V5, P237, DOI 10.1016/j.cmet.2007.03.006
   Ishikawa K, 2005, AM J HUM GENET, V77, P280, DOI 10.1086/432518
   Jaffe AB, 2005, ANNU REV CELL DEV BI, V21, P247, DOI 10.1146/annurev.cellbio.21.020604.150721
   Jaiswal N, 2019, MOL METAB, V28, P1, DOI 10.1016/j.molmet.2019.08.001
   Jebailey L, 2004, MOL ENDOCRINOL, V18, P359, DOI 10.1210/me.2003-0294
   JeBailey L, 2007, DIABETES, V56, P394, DOI 10.2337/db06-0823
   Jiang ZY, 2002, J BIOL CHEM, V277, P509, DOI 10.1074/jbc.M108280200
   Joseph GA, 2017, MOL CELL BIOL, V37, DOI 10.1128/MCB.00222-16
   Kalwat MA, 2013, EXP MOL MED, V45, DOI 10.1038/emm.2013.73
   Karnam P, 1997, J BIOL CHEM, V272, P6136, DOI 10.1074/jbc.272.10.6136
   Kepner EM, 2011, AM J PHYSIOL-ENDOC M, V301, pE1072, DOI 10.1152/ajpendo.00312.2011
   Kesavan G, 2014, DEVELOPMENT, V141, P685, DOI 10.1242/dev.100297
   Duong KHM, 2019, BIOCHEM BIOPH RES CO, V519, P880, DOI 10.1016/j.bbrc.2019.09.083
   Kim C, 2001, J IMMUNOL, V166, P1223, DOI 10.4049/jimmunol.166.2.1223
   Kim W, 2008, PHARMACOL REV, V60, P470, DOI 10.1124/pr.108.000604
   Kimura K, 1996, SCIENCE, V273, P245, DOI 10.1126/science.273.5272.245
   Kleinert M, 2014, MOL METAB, V3, P630, DOI 10.1016/j.molmet.2014.06.004
   KNAUS UG, 1991, SCIENCE, V254, P1512, DOI 10.1126/science.1660188
   KNAUS UG, 1995, SCIENCE, V269, P221, DOI 10.1126/science.7618083
   Koh CG, 2001, J CELL SCI, V114, P4239
   Kowluru RA, 2014, DIABETOLOGIA, V57, P1047, DOI 10.1007/s00125-014-3194-z
   KOZMA R, 1995, MOL CELL BIOL, V15, P1942
   Kuhn Sonja, 2014, Small GTPases, V5, pe29513, DOI 10.4161/sgtp.29513
   Kumar A, 2010, DIABETES, V59, P1397, DOI 10.2337/db09-1061
   Lang P, 1996, EMBO J, V15, P510, DOI 10.1002/j.1460-2075.1996.tb00383.x
   Laurin M, 2014, GENE DEV, V28, P533, DOI 10.1101/gad.236349.113
   Lawler S, 1999, CURR BIOL, V9, pR800, DOI 10.1016/S0960-9822(99)80493-X
   Lee DH, 2009, J BIOL CHEM, V284, P11776, DOI 10.1074/jbc.C900014200
   Lee HJ, 2017, CELL SIGNAL, V29, P150, DOI 10.1016/j.cellsig.2016.10.013
   Lewis JP, 2010, GENOMICS, V96, P211, DOI 10.1016/j.ygeno.2010.07.006
   Li SJ, 2002, J IMMUNOL, V169, P5043, DOI 10.4049/jimmunol.169.9.5043
   Lin MY, 2011, J CELL BIOL, V193, P985, DOI 10.1083/jcb.201103015
   Lucato CM, 2015, J BIOL CHEM, V290, P20827, DOI 10.1074/jbc.M115.660456
   MADAULE P, 1985, CELL, V41, P31, DOI 10.1016/0092-8674(85)90058-3
   Maltas J, 2020, BIOCHEM SOC T, V48, P2703, DOI 10.1042/BST20200481
   Manser E, 1998, MOL CELL, V1, P183, DOI 10.1016/S1097-2765(00)80019-2
   MANSER E, 1994, NATURE, V367, P40, DOI 10.1038/367040a0
   MARCUSOHN J, 1995, CURR BIOL, V5, P1296, DOI 10.1016/S0960-9822(95)00256-9
   Marinissen MT, 2001, GENE DEV, V15, P535, DOI 10.1101/gad.855801
   MARTIN GA, 1995, EMBO J, V14, P1970, DOI 10.1002/j.1460-2075.1995.tb07189.x
   McCulloch LJ, 2011, MOL GENET METAB, V104, P648, DOI 10.1016/j.ymgme.2011.08.026
   Menacho-Márquez M, 2013, CELL METAB, V18, P199, DOI 10.1016/j.cmet.2013.07.001
   Mense SM, 2015, SCI SIGNAL, V8, DOI 10.1126/scisignal.2005840
   Mîinea CP, 2005, BIOCHEM J, V391, P87, DOI 10.1042/BJ20050887
   Miki H, 1998, EMBO J, V17, P6932, DOI 10.1093/emboj/17.23.6932
   Miki H, 1998, NATURE, V391, P93, DOI 10.1038/34208
   Mitin N, 2012, METHODS MOL BIOL, V827, P87, DOI 10.1007/978-1-61779-442-1_6
   Mohammad G, 2019, MOL NEUROBIOL, V56, P8643, DOI 10.1007/s12035-019-01696-5
   Moller LLV, 2020, J PHYSIOL-LONDON, V598, P5351, DOI 10.1113/JP280294
   Moller LLV, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8050434
   Montalvo-Ortiz BL, 2012, J BIOL CHEM, V287, P13228, DOI 10.1074/jbc.M111.334524
   NOBES CD, 1995, CELL, V81, P53, DOI 10.1016/0092-8674(95)90370-4
   Noda K, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0110446
   Oberoi TK, 2012, EMBO J, V31, P14, DOI 10.1038/emboj.2011.423
   Oberoi-Khanuja Tripat Kaur, 2012, Small GTPases, V3, P131, DOI 10.4161/sgtp.19988
   Pandey D, 2009, BLOOD, V114, P415, DOI 10.1182/blood-2008-10-183582
   Paskus JD, 2020, TRENDS NEUROSCI, V43, P505, DOI 10.1016/j.tins.2020.05.002
   Perona R, 1997, GENE DEV, V11, P463, DOI 10.1101/gad.11.4.463
   Pessin JE, 2000, J CLIN INVEST, V106, P165, DOI 10.1172/JCI10582
   POLVERINO A, 1995, J BIOL CHEM, V270, P26067, DOI 10.1074/jbc.270.44.26067
   Porter Andrew P, 2016, Small GTPases, V7, P123, DOI 10.1080/21541248.2016.1173767
   Quevedo C, 2010, MOL BIOL CELL, V21, P1125, DOI 10.1091/mbc.E09-04-0292
   Radhakrishna H, 1999, J CELL SCI, V112, P855
   RIDLEY AJ, 1992, CELL, V70, P389, DOI 10.1016/0092-8674(92)90163-7
   Roberts PJ, 2008, J BIOL CHEM, V283, P25150, DOI 10.1074/jbc.M800882200
   Rodríguez-Fdez S, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-19489-z
   Rosenberger G, 2006, EUR J CELL BIOL, V85, P265, DOI 10.1016/j.ejcb.2005.10.007
   Rossman KL, 2005, NAT REV MOL CELL BIO, V6, P167, DOI 10.1038/nrm1587
   Sahai E, 2002, NAT REV CANCER, V2, P133, DOI 10.1038/nrc725
   Sauzeau V, 2010, J CLIN INVEST, V120, P315, DOI 10.1172/JCI38356
   Saxton RA, 2017, CELL, V168, P960, DOI [10.1016/j.cell.2017.02.004, 10.1016/j.cell.2017.03.035]
   Schmitz HP, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19082186
   Schmitz HP, 2015, MOL MICROBIOL, V96, P306, DOI 10.1111/mmi.12937
   Sha J, 2014, ENDOCRINOL METAB, V29, P363, DOI 10.3803/EnM.2014.29.3.363
   Shimizu T, 2000, J BIOL CHEM, V275, P18311, DOI 10.1074/jbc.M910274199
   Smith U, 2002, INT J OBESITY, V26, P897, DOI 10.1038/sj.ijo.0802028
   Spalding KL, 2008, NATURE, V453, P783, DOI 10.1038/nature06902
   Standaert M, 1998, J BIOL CHEM, V273, P7470, DOI 10.1074/jbc.273.13.7470
   Syed I, 2010, BIOCHEM PHARMACOL, V80, P874, DOI 10.1016/j.bcp.2010.05.006
   Sylow L, 2021, CELL METAB, V33, P758, DOI 10.1016/j.cmet.2021.03.020
   Sylow L, 2017, DIABETES, V66, P1548, DOI 10.2337/db16-1138
   Sylow L, 2016, J PHYSIOL-LONDON, V594, P4997, DOI 10.1113/JP272039
   Sylow L, 2014, CELL SIGNAL, V26, P323, DOI 10.1016/j.cellsig.2013.11.007
   Sylow L, 2013, DIABETES, V62, P1865, DOI 10.2337/db12-1148
   Sylow L, 2013, DIABETES, V62, P1139, DOI 10.2337/db12-0491
   Takenaka N, 2020, FEBS LETT, V594, P4370, DOI 10.1002/1873-3468.13939
   Takenaka N, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20215443
   Takenaka N, 2017, CELL SIGNAL, V39, P108, DOI 10.1016/j.cellsig.2017.08.004
   Teranishi T, 2007, METABOLISM, V56, P1418, DOI 10.1016/j.metabol.2007.06.005
   Thadhani R, 2010, DIABETES CARE, V33, P664, DOI 10.2337/dc09-1745
   Thamilselvan Vijayalakshmi, 2020, Cell Physiol Biochem, V54, P1218, DOI 10.33594/000000310
   Thong FSL, 2007, DIABETES, V56, P414, DOI 10.2337/db06-0900
   Tobón AL, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-27081-1
   Tsakiridis T, 1996, J BIOL CHEM, V271, P19664, DOI 10.1074/jbc.271.33.19664
   Tunduguru R, 2014, BIOCHEM PHARMACOL, V92, P380, DOI 10.1016/j.bcp.2014.08.033
   Turner M, 2002, NAT REV IMMUNOL, V2, P476, DOI 10.1038/nri840
   Ueda H, 2008, J BIOL CHEM, V283, P1946, DOI 10.1074/jbc.M707037200
   Ueda S, 2008, BIOL CELL, V100, P645, DOI 10.1042/BC20070160
   Ueda S, 2010, FASEB J, V24, P2254, DOI 10.1096/fj.09-137380
   Usui I, 2003, J BIOL CHEM, V278, P13765, DOI 10.1074/jbc.M208904200
   Vadlamudi RK, 2005, MOL CELL BIOL, V25, P3726, DOI 10.1128/MCB.25.9.3726-3736.2005
   Vanhaesebroeck B, 2012, NAT REV MOL CELL BIO, V13, P195, DOI 10.1038/nrm3290
   vanLeeuwen FN, 1997, J CELL BIOL, V139, P797, DOI 10.1083/jcb.139.3.797
   Veluthakal R, 2009, BIOCHEM PHARMACOL, V77, P101, DOI 10.1016/j.bcp.2008.09.021
   Veluthakal R, 2016, CELL PHYSIOL BIOCHEM, V39, P760, DOI 10.1159/000445666
   Veluthakal R, 2015, DIABETOLOGIA, V58, P2573, DOI 10.1007/s00125-015-3707-4
   Veluthakal R, 2015, CELL PHYSIOL BIOCHEM, V36, P208, DOI 10.1159/000374065
   Vigil D, 2010, NAT REV CANCER, V10, P842, DOI 10.1038/nrc2960
   Villalonga P, 2006, GROWTH FACTORS, V24, P159, DOI 10.1080/08977190600560651
   VOJTEK AB, 1995, CELL, V82, P527, DOI 10.1016/0092-8674(95)90023-3
   Walker H.K., 1990, CLIN METHODS
   Wang ZX, 2011, J BIOL CHEM, V286, P41359, DOI 10.1074/jbc.M111.291500
   Watanabe N, 1999, NAT CELL BIOL, V1, P136, DOI 10.1038/11056
   Welch HCE, 2002, CELL, V108, P809, DOI 10.1016/S0092-8674(02)00663-3
   Welch Heidi C E, 2015, Small GTPases, V6, P49, DOI 10.4161/21541248.2014.973770
   Welsh CF, 2001, NAT CELL BIOL, V3, P950, DOI 10.1038/ncb1101-950
   Wennerberg K, 2005, J CELL SCI, V118, P843, DOI 10.1242/jcs.01660
   Westwick JK, 1997, MOL CELL BIOL, V17, P1324, DOI 10.1128/MCB.17.3.1324
   Whitehead IP, 1997, BBA-REV CANCER, V1332, pF1, DOI 10.1016/S0304-419X(96)00040-6
   Widera C, 2009, CLIN CHEM, V55, P1794, DOI 10.1373/clinchem.2009.129411
   Wieczorek S, 2006, J HUM GENET, V51, P363, DOI 10.1007/s10038-006-0372-y
   Wilcox Gisela, 2005, Clin Biochem Rev, V26, P19
   Wu CL, 2016, NUCLEIC ACIDS RES, V44, pD313, DOI 10.1093/nar/gkv1104
   Xue RD, 2015, NAT MED, V21, P760, DOI 10.1038/nm.3881
   Yamagishi A, 2004, J BIOL CHEM, V279, P14929, DOI 10.1074/jbc.M309408200
   Yan Y, 2015, CEREB CORTEX, V25, P3487, DOI 10.1093/cercor/bhu182
   You GY, 2013, CELL SIGNAL, V25, P2558, DOI 10.1016/j.cellsig.2013.08.018
   Yue YY, 2021, FASEB J, V35, DOI 10.1096/fj.202001312R
   Yue YY, 2020, AM J PHYSIOL-ENDOC M, V318, pE330, DOI 10.1152/ajpendo.00272.2019
   Zhao Zhuo-Shen, 2012, Cell Logist, V2, P59
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI13505
NR 197
TC 24
Z9 26
U1 0
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD APR
PY 2021
VL 10
IS 4
AR 915
DI 10.3390/cells10040915
PG 27
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA RR1SB
UT WOS:000642885400001
PM 33923452
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cheraghi, Z
   Mirmiran, P
   Mansournia, MA
   Moslehi, N
   Khalili, D
   Nedjat, S
AF Cheraghi, Zahra
   Mirmiran, Parvin
   Mansournia, Mohammad Ali
   Moslehi, Nazanin
   Khalili, Davood
   Nedjat, Saharnaz
TI The association between nutritional exposures and metabolic syndrome in
   the Tehran Lipid and Glucose Study (TLGS): a cohort study
SO PUBLIC HEALTH
LA English
DT Article
DE Metabolic syndrome (MetS); Nutritional exposures; Tehran lipid and
   glucose study; Prospective study
ID FAST-FOOD CONSUMPTION; 3RD NATIONAL-HEALTH; C-REACTIVE PROTEIN;
   BODY-MASS INDEX; RISK-FACTORS; WAIST CIRCUMFERENCE; OXIDATIVE STRESS;
   ADULT-POPULATION; RICE INTAKE; PREVALENCE
AB Objectives: This study was conducted with the goal of investigating the effect of various food consumption on the incidence of metabolic syndrome (MetS).
   Study design: Prospective cohort study.
   Methods: This study conducted on 3616 healthy adults aged >= 20 years, who were not affected with MetS. Nutritional intake was determined at the beginning of the study (2008-2011) by the Food Frequency Questionnaire (FFQ), and the incidence of MetS was investigated after a median of 24.6 months follow-up. Data were analyzed by multiple logistic regression, with 95% confidence interval.
   Results: After adjusting the effect of other variables in the model many foods in the whole grains group - such as Sangak bread (OR = 0.35, 95% CI: 0.11-1.56), multiple types of vegetables and fruits such as peach (OR = 0.11, 95% CI: 0.01-0.75), and mushroom (OR = 0.28, 95% CI: 0.11-0.71) had protective effects against MetS. From the dairy group yoghurt (OR = 0.43, 95% CI: 0.18-1.01) and ice cream (OR = 0.35, 95% CI: 0.12-1.06) had similar such effects.
   Conclusion: Based on our findings, there was a significant rise in the incidence of MetS in Iran. The daily consumption of foods from the whole grains, dairy, vegetable and fruit groups can help reduce the odds of MetS. (C) 2016 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.
C1 [Cheraghi, Zahra; Mansournia, Mohammad Ali] Univ Tehran Med Sci, Dept Epidemiol & Biostat, Sch Publ Hlth, Tehran, Iran.
   [Mirmiran, Parvin; Moslehi, Nazanin] Shahid Beheshti Univ Med Sci, Nutr & Endocrine Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
   [Mirmiran, Parvin] Shahid Beheshti Univ Med Sci, Dept Clin Nutr & Dietet, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, Tehran, Iran.
   [Khalili, Davood] Shahid Beheshti Univ Med Sci, Prevent Metab Disorders Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
   [Khalili, Davood] Shahid Beheshti Univ Med Sci, Sch Publ Hlth, Dept Epidemiol, Tehran, Iran.
   [Nedjat, Saharnaz] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Knowledge Utilizat Res Ctr, Tehran, Iran.
C3 Tehran University of Medical Sciences; Shahid Beheshti University
   Medical Sciences; Shahid Beheshti University Medical Sciences; Shahid
   Beheshti University Medical Sciences; Shahid Beheshti University Medical
   Sciences; Tehran University of Medical Sciences
RP Mirmiran, P (corresponding author), Shahid Beheshti Univ Med Sci, Dept Clin Nutr & Dietet, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, Tehran, Iran.; Nedjat, S (corresponding author), Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Knowledge Utilizat Res Ctr, Tehran, Iran.
EM cheraghiz@ymail.com; mirmiran@endocrine.ac.ir; mansournia_ma@yahoo.com;
   moslehinazanin@yahoo.com; dkhalili@endocrine.ac.ir; nejatsan@tums.ac.ir
RI Cheraghi, Zahra/AAF-6877-2019; Moslehi, Nazanin/R-8154-2019; mansournia,
   Mohammad/AFA-8899-2022; Mirmiran, Parvin/V-1433-2019; Khalili,
   Davood/T-2913-2017; Cheraghi, Zahra/H-6376-2013
OI Khalili, Davood/0000-0003-4956-1039; Cheraghi,
   Zahra/0000-0001-9041-559X; Cheraghi, Zahra/0000-0001-6076-4916;
   Mansournia, Mohammad Ali/0000-0003-3343-2718; Mirmiran,
   Parvin/0000-0003-2391-4924; Moslehi, Nazanin/0000-0001-8441-5200
FU Tehran University of Medical Sciences (TUMS) [912-112-8002]
FX This article is one of the first author's Ph.D. thesis (Thesis code:
   912-112-8002) and supported by Tehran University of Medical Sciences
   (TUMS).
CR Adamson AJ, 2009, EUR J CLIN NUTR, V63, pS6, DOI 10.1038/ejcn.2008.60
   Ahn Y, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-61
   Azizi F, 2002, J HUM HYPERTENS, V16, P305, DOI 10.1038/sj.jhh.1001399
   Azizi F., 2000, Iran J Endocrinol Metabol, V2, P77
   Azizi F, 2010, ARCH IRAN MED, V13, P243
   Bahadoran Z, 2013, EUR J CLIN NUTR, V67, P1303, DOI 10.1038/ejcn.2013.217
   Bahadoran Z, 2014, ARCH IRAN MED, V17, P435, DOI 014176/AIM.0011
   Baty HS, 2008, ANESTHESIOLOGY, V108, P506, DOI 10.1097/ALN.0b013e3181649314
   Boutayeb A, 2006, T ROY SOC TROP MED H, V100, P191, DOI 10.1016/j.trstmh.2005.07.021
   COTTER AA., 2008, INT J DAIRY TECHNOL, V61, P213
   Cruz ML, 2004, J CLIN ENDOCR METAB, V89, P108, DOI 10.1210/jc.2003-031188
   Deshmukh-Taskar PR, PUBLIC HLTH NUTR
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Devaraj S, 2008, METABOLISM, V57, P867, DOI 10.1016/j.metabol.2008.02.016
   Esmaillzadeh A, 2005, EUR J CLIN NUTR, V59, P353, DOI 10.1038/sj.ejcn.1602080
   Esmaillzadeh A, 2006, AM J CLIN NUTR, V84, P1489, DOI 10.1093/ajcn/84.6.1489
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Foster-Powell K, 2002, AM J CLIN NUTR, V76, P5, DOI 10.1093/ajcn/76.1.5
   Fumeron F, J AM COLL NUTR
   Ghotbodin MS, 2014, IJEM, V16, P270
   Giugliano D, 2006, J AM COLL CARDIOL, V48, P677, DOI 10.1016/j.jacc.2006.03.052
   Greenland S., 2008, MODERN EPIDEMIOLOGY, P419
   Grundy SM, 2004, J CLIN ENDOCR METAB, V89, P2595, DOI 10.1210/jc.2004-0372
   Hadaegh F, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076304
   Hadaegh F, 2009, ANN ACAD MED SINGAP, V38, P142
   Hashemi M, 2010, CARDIOL YOUNG, V20, P73, DOI 10.1017/S1047951109990850
   Herring AH, 2010, EPIDEMIOLOGY, V21, pS71, DOI 10.1097/EDE.0b013e3181cf0058
   Hilpert KF, 2005, J NUTR, V135, P1075, DOI 10.1093/jn/135.5.1075
   Hosseinpour-Niazi S, 2015, J HUM NUTR DIET, V28, P236, DOI 10.1111/jhn.12242
   Hunt KJ., 2000, Genet Epidemiol
   Janghorbani M, 2012, ENDOKRYNOL POL, V63, P372
   Jekanowski MD, 2001, J AGR RESOUR ECON, V26, P58
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Maras JE, 2007, THESIS
   Medjakovic S, 2013, FOOD FUNCT, V4, P19, DOI 10.1039/c2fo30034f
   Mirmiran P, 2010, PUBLIC HEALTH NUTR, V13, P654, DOI 10.1017/S1368980009991698
   Mohensi-Takalloo S, 2013, IRANIAN J ENDOCRINOL, V15, P3
   Momenan AA, 2012, ARCH IRAN MED, V15, P279, DOI 012155/AIM.007
   Niemeier HM, 2006, J ADOLESCENT HEALTH, V39, P842, DOI 10.1016/j.jadohealth.2006.07.001
   Noel SE, 2009, J NUTR, V139, P1360, DOI 10.3945/jn.109.105874
   Orellana C, 2014, HYPERTENSION METABOL
   Prentice A M, 2003, Obes Rev, V4, P187, DOI 10.1046/j.1467-789X.2003.00117.x
   Rodríguez MM, 2002, PUBLIC HEALTH NUTR, V5, P691, DOI 10.1079/PHN2002333
   Ruidavets JB, 2007, J EPIDEMIOL COMMUN H, V61, P810, DOI 10.1136/jech.2006.052126
   Schlosser Eric., 2012, Fast Food Nation: The Dark Side of the All-American Meal
   Schröder H, 2007, BRIT J NUTR, V98, P1274, DOI 10.1017/S0007114507781436
   Shi ZM, 2012, ASIA PAC J CLIN NUTR, V21, P35
   Sirdah MM, 2011, DIABETES METAB SYND, V5, P93, DOI 10.1016/j.dsx.2012.02.024
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Song S, 2015, BRIT J NUTR, V113, P479, DOI 10.1017/S0007114514003845
   Soory Mena, 2012, Infectious Disorders - Drug Targets, V12, P388
   Tierney AC, 2011, INT J OBESITY, V35, P800, DOI 10.1038/ijo.2010.209
   Tortosa A, 2007, DIABETES CARE, V30, P2957, DOI 10.2337/dc07-1231
   Wang HF, 2011, OBESITY, V19, P2404, DOI 10.1038/oby.2011.234
   Wirfält E, 2001, AM J EPIDEMIOL, V154, P1150, DOI 10.1093/aje/154.12.1150
   WITTE JS, 1994, EPIDEMIOLOGY, V5, P612, DOI 10.1097/00001648-199411000-00009
   Yang FY, 2008, ASIA PAC J CLIN NUTR, V17, P339
   Zabetian A, 2007, DIABETES RES CLIN PR, V77, P251, DOI 10.1016/j.diabres.2006.12.001
NR 60
TC 14
Z9 15
U1 1
U2 4
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0033-3506
EI 1476-5616
J9 PUBLIC HEALTH
JI Public Health
PD NOV
PY 2016
VL 140
BP 163
EP 171
DI 10.1016/j.puhe.2016.07.003
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA EE2FD
UT WOS:000389398200026
PM 27498945
DA 2025-06-11
ER

PT J
AU Ersoy, K
   Anaforoglu, I
   Algün, E
AF Ersoy, Kerem
   Anaforoglu, Inan
   Algun, Ekrem
TI Serum ischemic modified albumin levels might not be a marker of
   oxidative stress in patients with hypothyroidism
SO ENDOCRINE
LA English
DT Article
DE Hypothyroidism; Subclinical hypothyroidism; Ischemic modified albumin;
   Ischemia
ID BINDING; ASSAY
AB Overt hypothyroidism and subclinical hypothyroidism are thought to be associated with atherosclerosis and a chronic ischemic process. Ischemic modified albumin (IMA) is a novel marker of ischemia. We examined serum IMA levels in patients with subclinical and overt hypothyroidism. We recruited patients who presented to our clinic for thyroid disease control. We compared demographic data, fasting blood sugar, serum lipid levels, and the prevalence of metabolic syndrome by the presence of overt, subclinical, and no hypothyroidism. Cobalt binding to albumin capacity was analyzed using a rapid colorimetric technique and compared among the groups. We assessed 11 men and 74 women with a mean age of 39.9 +/- 12 years. Of these, 48 (56.5 %) were euthyroid, 24 (28.2 %) had subclinical hypothyroidism, and 13 (15.3 %) had overt hypothyroidism. The groups did not differ significantly in terms of age; body mass index; waist circumference; systolic and diastolic blood pressures; levels of fasting and nonfasting blood sugar, high- and low-density lipoproteins, and triglycerides; and the presence of metabolic syndrome. Mean serum IMA level also did not differ significantly among the groups: 0.20 +/- 0.08 absorbance units (ABSU) in the euthyroid participants, 0.18 +/- 0.08 ABSU in those with subclinical hypothyroidism, and 0.20 +/- 0.09 ABSU in those with overt hypothyroidism (P = 0.754). Mean IMA values did not differ significantly by sex, cigarette use, the presence of metabolic syndrome, or the presence of thyroid autoantibodies. Serum IMA levels did not differ among patients with overt or subclinical hypothyroidism in this case-control study.
C1 [Ersoy, Kerem; Algun, Ekrem] Trabzon Numune Egitim & Arastirma Hastanesi, Dept Endocrinol, TR-61000 Trabzon, Turkey.
   [Anaforoglu, Inan] Trabzon Numune Egitim & Arastirma Hastanesi, Endokrinol Klin, TR-61000 Trabzon, Turkey.
C3 Trabzon Kanuni Training & Research Hospital; Trabzon Kanuni Training &
   Research Hospital
RP Anaforoglu, I (corresponding author), Trabzon Numune Egitim & Arastirma Hastanesi, Endokrinol Klin, TR-61000 Trabzon, Turkey.
EM ianaforoglu@hotmail.com
RI ANAFOROĞLU, İNAN/AAG-8413-2021
FU Sanofi-Aventis (Istanbul, Turkey)
FX English language editing of this manuscript was performed by Patricia
   French of Left Lane Communications (Chapel Hill, NC, USA) and funded by
   Sanofi-Aventis (Istanbul, Turkey).
CR Almandoz JP, 2012, MED CLIN N AM, V96, P203, DOI 10.1016/j.mcna.2012.01.005
   Altinova A. E., 2006, METABOLISM, V65, P1380
   Bar-Or D, 2000, J EMERG MED, V19, P311, DOI 10.1016/S0736-4679(00)00255-9
   Bar-Or D, 2001, EUR J BIOCHEM, V268, P42, DOI 10.1046/j.1432-1327.2001.01846.x
   Chang D, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027218
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Coria Mariela Janet, 2009, Acta Biomed, V80, P135
   Gaze DC, 2009, DRUG METAB PHARMACOK, V24, P333, DOI 10.2133/dmpk.24.333
   Isman ÇA, 2003, J ENDOCRINOL, V177, P471, DOI 10.1677/joe.0.1770471
   Ma SG, 2012, ENDOCRINE, V42, P570, DOI 10.1007/s12020-012-9652-9
   Ma SG, 2012, EUR J INTERN MED, V23, pE136, DOI 10.1016/j.ejim.2012.04.011
   Ma SG, 2011, CLINICS, V66, P1677, DOI 10.1590/S1807-59322011001000003
   Moulakakis KG, 2008, IN VIVO, V22, P603
   Mudau M, 2012, CARDIOVASC J AFR, V23, DOI 10.5830/CVJA-2011-068
   Oge A, 2004, ENDOCR RES, V30, P481, DOI 10.1081/ERC-200036185
   Oner FA, 2011, ACTA CARDIOL, V66, P47, DOI 10.2143/AC.66.1.2064966
   Sarandöl E, 2005, CELL BIOCHEM FUNCT, V23, P1, DOI 10.1002/cbf.1119
   SWAROOP A, 1985, BIOCHEM J, V226, P403, DOI 10.1042/bj2260403
   Tian LM, 2010, EUR J INTERN MED, V21, P560, DOI 10.1016/j.ejim.2010.08.005
   Ukinc K, 2009, ENDOCRINE, V36, P425, DOI 10.1007/s12020-009-9236-5
   Valentina VN, 2011, ARQ BRAS ENDOCRINOL, V55, P475, DOI 10.1590/S0004-27302011000700007
   Venditti P, 1997, J ENDOCRINOL, V155, P151, DOI 10.1677/joe.0.1550151
NR 22
TC 10
Z9 10
U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD APR
PY 2013
VL 43
IS 2
BP 430
EP 433
DI 10.1007/s12020-012-9796-7
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 106CX
UT WOS:000316120300027
PM 23001626
DA 2025-06-11
ER

PT J
AU Jang, SJ
   Chu, CM
   Yang, TY
   Lin, YS
   Tsai, MF
   Chang, ST
AF Jang, Shih-Jung
   Chu, Chi-Ming
   Yang, Teng-Yao
   Lin, Yu-Sheng
   Tsai, Ming-Feng
   Chang, Shih-Tai
TI Coronary Artery Phenotypes in Subjects With Negative Myocardial
   Perfusion Imaging and Typical Angina Pectoris
SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES
LA English
DT Article
DE Myocardial perfusion scintigraphy; Coronary artery disease; Metabolic
   syndrome; Obesity
ID PROGNOSTIC VALUE; DIAGNOSTIC-ACCURACY; SEGMENTAL ANALYSIS; STRESS TEST;
   FOLLOW-UP; TL-201; SCINTIGRAPHY; DISEASE; PREDICTORS; EXTENT
AB Introduction: Limited data are available on coronary lesion morphology for patients with false-negative radionuclide findings together with typical angina symptoms. Methods: The study group consisted of 25 subjects with a negative pharmacological thallium (Tl)-201 single-photon emission computed tomography perfusion imaging study but typical angina symptoms and coronary artery disease (CAD) confirmed by coronary angiography. The control group included 690 subjects with a positive pharmacological Tl-201 single-photon emission computed tomography study and CAD. Results: The study group showed a significantly older and higher female ratio than the control group. Significant differences were found between the 2 groups in the presence of current smoking status and hypertension. A noticeably higher percentage of positive metabolic syndrome ratio, number of metabolic syndrome components, high waist-to-hip ratio percentage and high waist circumference percentage in the study group. The study group was noticeably lower in mean numbers of culprit vessel involvement and mean lesion numbers than the control group. There were more individuals with type A classification and a lower proportion of complex stenoses-which contain type B2 and C lesions-in the study group than in the control group. The study group had significantly fewer calcified stenoses and complex morphology stenoses-the latter of which include lesion morphologies with chronic total occlusion, diffuse and calcification-than the control group. Conclusions: For the high probability of CAD lesions that requires interventional therapy, patients with negative myocardial scintigraphy but typical angina symptoms would be beneficial to intensive medical treatment and coronary study.
C1 [Jang, Shih-Jung; Yang, Teng-Yao; Lin, Yu-Sheng; Chang, Shih-Tai] Chiayi Chang Gung Mem Hosp, Div Cardiol, Pu Tz City, Chai Yi Hsien, Taiwan.
   [Tsai, Ming-Feng] Chiayi Chang Gung Mem Hosp, Div Nucl Med, Pu Tz City, Chai Yi Hsien, Taiwan.
   [Jang, Shih-Jung; Yang, Teng-Yao; Lin, Yu-Sheng; Chang, Shih-Tai] Chiayi Sch, Chang Gung Inst Technol, Chiayi Hsien, Taiwan.
   [Jang, Shih-Jung; Yang, Teng-Yao; Lin, Yu-Sheng; Chang, Shih-Tai] Chang Gung Univ, Coll Med, Tao Yuan, Taiwan.
   [Chu, Chi-Ming] Natl Def Med Ctr & Univ, Inst Publ Hlth, Sect Hlth Informat, Taipei, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung Memorial Hospital; Chang Gung
   University of Science & Technology; Chang Gung University; National
   Defense Medical Center
RP Chang, ST (corresponding author), Chiayi Chang Gung Mem Hosp, Div Cardiol, 6 Sec W Chai Pu Rd, Pu Tz City, Chai Yi Hsien, Taiwan.
EM cst1234567@yahoo.com.tw
RI Chu, Christopher/HHN-4195-2022
OI Chu, Cordia/0000-0002-3683-5638
CR BOTVINICK EH, 1980, SEMIN NUCL MED, V10, P157, DOI 10.1016/S0001-2998(80)80018-3
   BROWN KA, 1983, J AM COLL CARDIOL, V1, P994, DOI 10.1016/S0735-1097(83)80100-4
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   DIAMOND GA, 1979, NEW ENGL J MED, V300, P1350, DOI 10.1056/NEJM197906143002402
   ELLIS SG, 1990, CIRCULATION, V82, P1193, DOI 10.1161/01.CIR.82.4.1193
   Fujimoto S, 2006, CIRC J, V70, P297, DOI 10.1253/circj.70.297
   Hansen CL, 2000, AM J CARDIOL, V85, P749, DOI 10.1016/S0002-9149(99)00853-X
   ISKANDRIAN AS, 1985, AM HEART J, V110, P135, DOI 10.1016/0002-8703(85)90527-7
   LADENHEIM ML, 1986, J AM COLL CARDIOL, V7, P464, DOI 10.1016/S0735-1097(86)80454-5
   LENAERS A, 1977, J NUCL MED, V18, P509
   LEPPO J, 1979, CIRCULATION, V59, P714, DOI 10.1161/01.CIR.59.4.714
   MACHECOURT J, 1994, J AM COLL CARDIOL, V23, P1096, DOI 10.1016/0735-1097(94)90597-5
   MAHMARIAN JJ, 1991, AM J CARDIOL, V67, pD2, DOI 10.1016/S0002-9149(05)80002-5
   MARIE PY, 1995, J AM COLL CARDIOL, V26, P879, DOI 10.1016/0735-1097(95)00243-9
   MASSIE BM, 1979, AM J CARDIOL, V44, P616, DOI 10.1016/0002-9149(79)90278-9
   Metz LD, 2007, J AM COLL CARDIOL, V49, P227, DOI 10.1016/j.jacc.2006.08.048
   Navare SM, 2004, J NUCL CARDIOL, V11, P551, DOI 10.1016/j.nuclcard.2004.06.128
   OKADA RD, 1980, AM J CARDIOL, V46, P619, DOI 10.1016/0002-9149(80)90512-3
   PAMELIA FX, 1985, AM J CARDIOL, V55, P920, DOI 10.1016/0002-9149(85)90718-0
   PORT SC, 1985, J AM COLL CARDIOL, V6, P75, DOI 10.1016/S0735-1097(85)80256-4
   RIGO P, 1980, CIRCULATION, V61, P973, DOI 10.1161/01.CIR.61.5.973
   STEINBERG EH, 1993, AM J CARDIOL, V71, P1270, DOI 10.1016/0002-9149(93)90538-N
   TROBAUGH GB, 1978, J NUCL MED, V19, P359
   Vanzetto G, 1999, CIRCULATION, V100, P1521, DOI 10.1161/01.CIR.100.14.1521
NR 24
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9629
EI 1538-2990
J9 AM J MED SCI
JI Am. J. Med. Sci.
PD NOV
PY 2010
VL 340
IS 5
BP 350
EP 355
DI 10.1097/MAJ.0b013e3181ee2f4e
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 675CI
UT WOS:000283802300002
PM 20724904
DA 2025-06-11
ER

PT J
AU Tsou, MT
   Chen, JY
AF Tsou, Meng-Ting
   Chen, Jau-Yuan
TI Burnout and metabolic syndrome among healthcare workers: Is subclinical
   hypothyroidism a mediator?
SO JOURNAL OF OCCUPATIONAL HEALTH
LA English
DT Article
DE burnout; healthcare workers; metabolic syndrome; Taiwan
ID SHIFT WORK; STRESS; RISK; ASSOCIATION; DISEASE
AB Objectives Evidence suggests that subclinical hypothyroidism (SCH) is associated with burnout and metabolic syndrome (MetS). We examined the relationship between burnout and MetS among healthcare workers (HCWs) and investigated the potential mediation of SCH. Methods This cross-sectional study included HCWs from a tertiary medical center; demographic data were obtained using a questionnaire. Burnout was evaluated according to the Chinese version of the Maslach Burnout Inventory-Health Services Survey (MBI-HSS). MetS and thyroid function data were obtained from a physical check-up. Logistic regression models were used to evaluate the adjusted odds ratio (aOR), and mediation analysis was employed to examine the mediation effect. Results Among 945 non-doctor/nurse and 1868 doctor/nurse staff, MetS was 30% and 14%, respectively, and the prevalence of burnout was nearly 6.5%. The results showed that burnout induced higher aOR of MetS in the doctor/nurse group (1.27, 95% confidence interval [CI]: 1.05-3.62). Thyroid-stimulating hormone (TSH) showed a positive association factor of MetS in doctor/nurse group-adjusted burnout (aOR = 1.15, 95% CI: 1.01-4.19). A higher TSH level was associated with an increased odds of MetS in younger doctor/nurse staff with burnout syndrome (aOR = 1.74; 95% CI: 1.04-3.22). There was a borderline significant mediation effect of SCH in the association between burnout and MetS in doctor/nurse staff. Conclusions The results showed that higher TSH levels were positively associated with burnout and MetS in doctor/nurse professionals, especially in the young cohort. Burnout may rely on the borderline mediation effect of SCH, which is likely to affect MetS.
C1 [Tsou, Meng-Ting] MacKay Mem Hosp, Dept Family Med, Taipei, Taiwan.
   [Tsou, Meng-Ting] MacKay Mem Hosp, Dept Occupat Med, Taipei, Taiwan.
   [Tsou, Meng-Ting] Dept MacKay Jr Coll Med Nursing & Management, New Taipei, Taiwan.
   [Chen, Jau-Yuan] Chang Gung Mem Hosp, Linkou Branch, Dept Family Med, 5 Fuxing St, Taoyuan 333, Taiwan.
   [Chen, Jau-Yuan] Chang Gung Univ, Coll Med, Taoyuan, Taiwan.
C3 Mackay Memorial Hospital; Mackay Memorial Hospital; Chang Gung Memorial
   Hospital; Chang Gung University
RP Chen, JY (corresponding author), Chang Gung Mem Hosp, Linkou Branch, Dept Family Med, 5 Fuxing St, Taoyuan 333, Taiwan.
EM welins@cgmh.org.tw
RI Chen, Hsing-yu/C-3979-2011
CR [Anonymous], 2018, ILOSH105M309 ILOSH105M309, V6
   Åsberg M, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0003590
   Bergmann N, 2014, ENDOCR CONNECT, V3, pR55, DOI 10.1530/EC-14-0031
   Bonora BM, 2016, METAB SYNDR RELAT D, V14, P378, DOI 10.1089/met.2016.29009.bon
   Cagampang FR, 2011, BRAIN BEHAV IMMUN, V25, P214, DOI 10.1016/j.bbi.2010.09.005
   Chang CH, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-07004-2
   Cheng YW, 2014, INT J CARDIOL, V171, P419, DOI 10.1016/j.ijcard.2013.12.035
   Cheserek MJ, 2014, INT J OCCUP MED ENV, V27, P175, DOI 10.2478/s13382-014-0240-5
   Chico-Barba G, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16111993
   Chou LP, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2013-004185
   Coppeta Luca, 2020, Endocr Regul, V54, P64, DOI 10.2478/enr-2020-0008
   Danhof-Pont MB, 2011, J PSYCHOSOM RES, V70, P505, DOI 10.1016/j.jpsychores.2010.10.012
   das Merces MC, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16152686
   Felton JS, 1998, OCCUP MED-OXFORD, V48, P237, DOI 10.1093/occmed/48.4.237
   Guo YF, 2017, PSYCHONEUROENDOCRINO, V77, P47, DOI 10.1016/j.psyneuen.2016.11.020
   HAGGERTY JJ, 1993, AM J PSYCHIAT, V150, P508
   Harbeck B, 2015, J OCCUP HEALTH, V57, P438, DOI 10.1539/joh.14-0276-OA
   Hwang LC, 2007, EUR J EPIDEMIOL, V22, P899, DOI 10.1007/s10654-007-9183-5
   Jones DD, 2010, AM J MED, V123, P502, DOI 10.1016/j.amjmed.2009.12.023
   Kim JS, 2018, J CLIN ENDOCR METAB, V103, P1827, DOI 10.1210/jc.2017-01247
   Kobayashi T, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-395
   Lee Lu L., 2005, Res Appl Psychol, V7, P59, DOI DOI 10.12809/HKMJ166143
   Lee MB, 2003, J FORMOS MED ASSOC, V102, P687
   Lin CC, 2007, BMC PUBLIC HEALTH, V7, DOI 10.1186/1471-2458-7-239
   Gómez-Urquiza JL, 2017, CRIT CARE NURSE, V37, pE1, DOI 10.4037/ccn2017508
   Nadolnik L. I., 2010, Biomeditsinskaya Khimiya, V56, P443
   Sánchez-Jiménez B, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15040634
   Schaufeli WB, 2009, CAREER DEV INT, V14, P204, DOI 10.1108/13620430910966406
   Soares JJF, 2007, ARCH WOMEN MENT HLTH, V10, P61, DOI 10.1007/s00737-007-0170-3
   Tingley D, 2014, J STAT SOFTW, V59
   Tsou MT, 2021, J OCCUP HEALTH, V63, DOI 10.1002/1348-9585.12188
   Wang XS, 2011, OCCUP MED-OXFORD, V61, P78, DOI 10.1093/occmed/kqr001
   Wei CY, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/369179
   Wisetborisut A, 2014, OCCUP MED-OXFORD, V64, P279, DOI 10.1093/occmed/kqu009
   Yang LB, 2016, ENDOCR RES, V41, P158, DOI 10.3109/07435800.2015.1108332
   Yeh CJ, 2011, ASIA PAC J CLIN NUTR, V20, P292
   Yeh WC, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000011664
NR 37
TC 4
Z9 4
U1 0
U2 9
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1341-9145
EI 1348-9585
J9 J OCCUP HEALTH
JI J. Occup. Health
PD JAN
PY 2021
VL 63
IS 1
AR e12252
DI 10.1002/1348-9585.12252
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA TK7ZS
UT WOS:000674374000001
PM 34286911
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Morel, S
   Delvin, E
   Marcil, V
   Levy, E
AF Morel, Sophia
   Delvin, Edgard
   Marcil, Valerie
   Levy, Emile
TI Intestinal Dysbiosis and Development of Cardiometabolic Disorders in
   Childhood Cancer Survivors: A Critical Review
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
DE cancer survivors; metabolic syndrome; gut microbiota; dysbiosis;
   oxidative stress; inflammation
ID ACUTE LYMPHOBLASTIC-LEUKEMIA; LONG-TERM SURVIVORS; CARDIOVASCULAR
   RISK-FACTORS; YOUNG-ADULT SURVIVORS; HEMATOPOIETIC-CELL TRANSPLANTATION;
   IMPAIRED GLUCOSE-TOLERANCE; GROWTH-HORMONE DEFICIENCY; METABOLIC
   SYNDROME; INSULIN-RESISTANCE; GUT MICROBIOTA
AB Significance: Survivors of pediatric cancers have a high risk of developing side effects after the end of their treatments. Many potential factors have been associated with the onset of cardiometabolic disorders (CMD), including cancer disease itself, chemotherapy, hormonal treatment, radiotherapy, and genetics. However, the precise etiology and underlying mechanisms of these long-term complications are poorly understood.
   Recent Advances: Greater awareness is currently paid to the role of microbiota in the emergence of cancers and modulation of cancer therapies in both children and adults. Alterations in the composition and diversity of intestinal microbiota can clearly influence tumor development and progression as well as immune responses and clinical output. As dysbiosis is closely linked to the development of host metabolic diseases, including obesity, metabolic syndrome, type 2 diabetes, and non-alcoholic fatty liver disease, it may increase the risk of CMD in cancer populations.
   Critical Issues: Only limited studies targeting the profile of intestinal dysbiosis before and after cancer treatment have been conducted. Further, the exact contribution of intestinal dysbiosis to the development of CMD in cancer survivors is poorly appreciated. This review intends to clarify the influence of gut microbiota on CMD in childhood cancer survivors, elucidate the potential mechanisms, and evaluate the latest research on the interplay between diet/food supplement, microbiota, and cancer-related CMD.
   Future Directions: The implication of intestinal dysbiosis in late metabolic complications of childhood cancer survivors should be clarified. Intervention strategies could be developed to reduce the risk of survivors to CMD.
C1 [Morel, Sophia; Delvin, Edgard; Marcil, Valerie; Levy, Emile] Univ Montreal, St Justine Univ Hosp Hlth Ctr, Res Ctr, Montreal, PQ, Canada.
   [Morel, Sophia; Marcil, Valerie; Levy, Emile] Univ Montreal, Dept Nutr, Montreal, PQ, Canada.
   [Levy, Emile] Univ Montreal, Dept Pediat, Montreal, PQ, Canada.
C3 Universite de Montreal; Universite de Montreal; Universite de Montreal
RP Levy, E (corresponding author), CHU St Justine, Res Ctr, 3175 Cote Ste Catherine, Montreal, PQ H3T 1C5, Canada.
EM emile.levy@recherche-ste-justine.qc.ca
FU Institute of Cancer Research of the Canadian Institutes of Health
   Research; JA deSeve Research Chair in nutrition; FRSQ doctoral
   scholarship award; Cole Foundation Fellowship
FX This work was supported by a grant from the Institute of Cancer Research
   of the Canadian Institutes of Health Research (V.M. and E.L.), the JA
   deSeve Research Chair in nutrition (E.L.), the FRSQ doctoral scholarship
   award, and Cole Foundation Fellowship (S.M.).
CR Akbari V, 2016, NUTR REV, V74, P774, DOI 10.1093/nutrit/nuw039
   Aldhafiri F, 2012, PEDIATR BLOOD CANCER, V59, P133, DOI 10.1002/pbc.24012
   Amar J, 2011, EMBO MOL MED, V3, P559, DOI 10.1002/emmm.201100159
   Ariffin H, 2017, CANCER-AM CANCER SOC, V123, P4207, DOI 10.1002/cncr.30857
   Armenian SH, 2012, BLOOD, V120, P4505, DOI 10.1182/blood-2012-06-437178
   Arvidson J, 2000, PEDIATR HEMAT ONCOL, V17, P285, DOI 10.1080/088800100276271
   Azanan MS, 2016, EUR J IMMUNOL, V46, P1715, DOI 10.1002/eji.201646356
   Bai JB, 2018, SUPPORT CARE CANCER, V26, P427, DOI 10.1007/s00520-017-3982-3
   Bailey MA, 2018, ADV NUTR, V9, P193, DOI 10.1093/advances/nmy013
   Barbosa-Cortés L, 2017, BMC CANCER, V17, DOI 10.1186/s12885-017-3097-8
   Barnea D, 2015, ONCOLOGY-NY, V29, P849
   Basaria S, 2006, CANCER-AM CANCER SOC, V106, P581, DOI 10.1002/cncr.21642
   Beaumont M, 2016, GENOME BIOL, V17, DOI 10.1186/s13059-016-1052-7
   Belle FN, 2018, CANCER-AM CANCER SOC, V124, P3576, DOI 10.1002/cncr.31599
   Bezine E, 2014, CELLS-BASEL, V3, P592, DOI 10.3390/cells3020592
   Bhatt AP, 2017, CA-CANCER J CLIN, V67, P327, DOI 10.3322/caac.21398
   Bizzarri C, 2015, PEDIATR BLOOD CANCER, V62, P1650, DOI 10.1002/pbc.25603
   Blijdorp K, 2013, LEUKEMIA RES, V37, P367, DOI 10.1016/j.leukres.2012.12.008
   Boland AM, 2016, PHYS THER, V96, P1029, DOI 10.2522/ptj.20150507
   Boucher J, 2014, CSH PERSPECT BIOL, V6, DOI 10.1101/cshperspect.a009191
   Boulangé CL, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0303-2
   Buttros DDB, 2013, MENOPAUSE, V20, P448, DOI 10.1097/gme.0b013e318272bd4a
   Byndloss MX, 2017, SCIENCE, V357, P570, DOI 10.1126/science.aam9949
   Canadian Cancer Society National Cancer Institute of Canada, 2008, CAN CANC STAT 2008
   Cani PD, 2018, GUT, V67, P1716, DOI 10.1136/gutjnl-2018-316723
   Cao ST, 2018, J ANIM SCI, V96, P1795, DOI 10.1093/jas/sky104
   Carow B, 2014, FRONT IMMUNOL, V5, DOI 10.3389/fimmu.2014.00058
   Casco S, 2016, HORM CANCER-US, V7, P289, DOI 10.1007/s12672-016-0274-1
   Cerf-Bensussan N, 2010, NAT REV IMMUNOL, V10, P735, DOI 10.1038/nri2850
   Chao C, 2016, J PEDIAT HEMATOL ONC, V38, P123, DOI 10.1097/MPH.0000000000000492
   Chaosuwannakit N, 2010, J CLIN ONCOL, V28, P166, DOI 10.1200/JCO.2009.23.8527
   Chemaitilly W, 2010, ENDOCR-RELAT CANCER, V17, pR141, DOI 10.1677/ERC-10-0002
   Chen MH, 2011, CIRC RES, V108, P619, DOI 10.1161/CIRCRESAHA.110.224519
   Cheung YT, 2015, ANN ONCOL, V26, P1446, DOI 10.1093/annonc/mdv206
   Chow EJ, 2007, CANCER-AM CANCER SOC, V110, P2313, DOI 10.1002/cncr.23050
   Chow EJ, 2010, BIOL BLOOD MARROW TR, V16, P1674, DOI 10.1016/j.bbmt.2010.05.016
   Chua LL, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0250-1
   Chueh HW, 2017, ANN PEDIATR ENDOCRIN, V22, P82, DOI 10.6065/apem.2017.22.2.82
   Conklin Kenneth A, 2004, Integr Cancer Ther, V3, P294, DOI 10.1177/1534735404270335
   Conroy ME, 2009, CURR OPIN ALLERGY CL, V9, P197, DOI 10.1097/ACI.0b013e32832b3f1d
   Cozen W, 2013, BRIT J CANCER, V108, P1163, DOI 10.1038/bjc.2013.60
   Cupit-Link MC, 2017, ESMO OPEN, V2, DOI 10.1136/esmoopen-2017-000250
   Daniel S, 2018, CLIN EPIGENETICS, V10, DOI 10.1186/s13148-018-0561-5
   Dao MC, 2018, EUR J INTERN MED, V48, P18, DOI 10.1016/j.ejim.2017.10.005
   de Haas EC, 2010, LANCET ONCOL, V11, P193, DOI 10.1016/S1470-2045(09)70287-6
   de Luca A, 2017, EPIGENOMICS-UK, V9, P893, DOI 10.2217/epi-2016-0168
   De Silva A, 2012, GUT LIVER, V6, P10, DOI 10.5009/gnl.2012.6.1.10
   Almondes KGD, 2014, NUTRITION, V30, P563, DOI 10.1016/j.nut.2013.10.012
   de Vathaire F, 2012, LANCET ONCOL, V13, P1002, DOI 10.1016/S1470-2045(12)70323-6
   DeSantis CE, 2014, CA-CANCER J CLIN, V64, P252, DOI 10.3322/caac.21235
   Dethlefsen L, 2011, P NATL ACAD SCI USA, V108, P4554, DOI 10.1073/pnas.1000087107
   Duplain H, 2001, CIRCULATION, V104, P342, DOI 10.1161/01.CIR.104.3.342
   Ebbert JO, 2013, NUTRIENTS, V5, P498, DOI 10.3390/nu5020498
   England J, 2017, BMC CANCER, V17, DOI 10.1186/s12885-017-3722-6
   Essig S, 2014, LANCET ONCOL, V15, P841, DOI 10.1016/S1470-2045(14)70265-7
   FABER M, 1995, BIOL TRACE ELEM RES, V47, P117, DOI 10.1007/BF02790108
   Faïs T, 2018, TOXINS, V10, DOI 10.3390/toxins10040151
   Farb MG, 2015, HORM MOL BIOL CLIN I, V21, P125, DOI 10.1515/hmbci-2014-0047
   Felicetti F, 2015, EUR J PREV CARDIOL, V22, P762, DOI 10.1177/2047487314529348
   Fijlstra M, 2015, SUPPORT CARE CANCER, V23, P1513, DOI 10.1007/s00520-014-2487-6
   Follin C, 2006, J CLIN ENDOCR METAB, V91, P1872, DOI 10.1210/jc.2005-2298
   Fournier M, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-40906-x
   Francisqueti FV, 2017, REV ASSOC MED BRAS, V63, P85
   Friedman DN, 2017, BIOL BLOOD MARROW TR, V23, P475, DOI 10.1016/j.bbmt.2016.12.623
   Ganz PA, 2013, BRAIN BEHAV IMMUN, V30, pS99, DOI 10.1016/j.bbi.2012.07.015
   Garmey EG, 2008, J CLIN ONCOL, V26, P4639, DOI 10.1200/JCO.2008.16.3527
   Geenen MM, 2010, PEDIATR BLOOD CANCER, V55, P690, DOI 10.1002/pbc.22518
   Grosso G, 2017, CRIT REV FOOD SCI, V57, P3218, DOI 10.1080/10408398.2015.1107021
   Guarner F, 2003, LANCET, V361, P512, DOI 10.1016/S0140-6736(03)12489-0
   Gunn HM, 2016, J ADOLESC YOUNG ADUL, V5, P24, DOI 10.1089/jayao.2015.0036
   Gurney JG, 2006, CANCER-AM CANCER SOC, V107, P1303, DOI 10.1002/cncr.22120
   Gurney JG, 2012, PEDIATR BLOOD CANCER, V59, P1307, DOI 10.1002/pbc.24134
   Guzzinat S, 2018, BMC CANCER, V18, DOI 10.1186/s12885-018-4053-y
   Haddy TB, 2006, PEDIATR BLOOD CANCER, V46, P258, DOI 10.1002/pbc.20485
   Hald S, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0159223
   Hashimoto M, 1998, INT J OBESITY, V22, P477, DOI 10.1038/sj.ijo.0800620
   Healey GR, 2017, NUTR REV, V75, P1059, DOI 10.1093/nutrit/nux062
   Hendijani F, 2018, CLIN NUTR, V37, P532, DOI 10.1016/j.clnu.2017.02.015
   Hoffman KE, 2008, PEDIATR BLOOD CANCER, V50, P341, DOI 10.1002/pbc.21363
   Houston M, 2014, WORLD J CARDIOL, V6, P38, DOI 10.4330/wjc.v6.i2.38
   Huang YK, 2012, EXP BIOL MED, V237, P305, DOI 10.1258/ebm.2011.011297
   Hurrle S, 2017, BIOMED J, V40, P257, DOI 10.1016/j.bj.2017.06.007
   Janiszewski PM, 2007, J CLIN ENDOCR METAB, V92, P3816, DOI 10.1210/jc.2006-2178
   Järvelä LS, 2013, PEDIATR BLOOD CANCER, V60, P1546, DOI 10.1002/pbc.24565
   Järvelä LS, 2010, J CANCER SURVIV, V4, P339, DOI 10.1007/s11764-010-0131-0
   Jenei Z, 2013, PATHOL ONCOL RES, V19, P375, DOI 10.1007/s12253-012-9589-6
   JENNEY MEM, 1995, MED PEDIATR ONCOL, V24, P222, DOI 10.1002/mpo.2950240403
   Johnson AA, 2012, REJUV RES, V15, P483, DOI 10.1089/rej.2012.1324
   Jung HS, 2012, DIABETES RES CLIN PR, V95, P275, DOI 10.1016/j.diabres.2011.08.029
   Kang YE, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0154003
   Kavey REW, 2006, CIRCULATION, V114, P2710, DOI 10.1161/CIRCULATIONAHA.106.179568
   Kesler S, 2013, BRAIN BEHAV IMMUN, V30, pS109, DOI 10.1016/j.bbi.2012.05.017
   Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213
   Kong C, 2019, SCI CHINA LIFE SCI, V62, P1178, DOI 10.1007/s11427-018-9456-x
   Lazar V, 2019, FRONT NUTR, V6, DOI 10.3389/fnut.2019.00021
   Le Gouill E, 2007, DIABETES, V56, P2690, DOI 10.2337/db06-1228
   Leahy J, 2018, METABOLISM, V85, P151, DOI 10.1016/j.metabol.2018.03.011
   Lega IC, 2018, CAN J DIABETES, V42, P533, DOI 10.1016/j.jcjd.2018.01.004
   Lemay V, 2019, J PEDIAT HEMATOL ONC, V41, pE450, DOI 10.1097/MPH.0000000000001426
   Levy E, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-17716-0
   Li CY, 2015, MED ONCOL, V32, DOI 10.1007/s12032-014-0422-9
   Liu F, 2017, EUR J CLIN NUTR, V71, P9, DOI 10.1038/ejcn.2016.156
   Louis P, 2017, ENVIRON MICROBIOL, V19, P29, DOI 10.1111/1462-2920.13589
   Lyon DE, 2016, J NEUROIMMUNOL, V301, P74, DOI 10.1016/j.jneuroim.2016.11.002
   Malhotra J, 2012, J LIPID RES, V53, P2747, DOI 10.1194/jlr.P029785
   Malvezzi M, 2015, ANN ONCOL, V26, P779, DOI 10.1093/annonc/mdv001
   Manichanh C, 2008, AM J GASTROENTEROL, V103, P1754, DOI 10.1111/j.1572-0241.2008.01868.x
   Mazidi M, 2016, DIAB MET SYND CLIN R, V10, pS150, DOI 10.1016/j.dsx.2016.01.024
   MCNEIL NI, 1984, AM J CLIN NUTR, V39, P338, DOI 10.1093/ajcn/39.2.338
   Meacham LR, 2010, CANCER EPIDEM BIOMAR, V19, P170, DOI 10.1158/1055-9965.EPI-09-0555
   Meacham LR, 2009, ARCH INTERN MED, V169, P1381, DOI 10.1001/archinternmed.2009.209
   Meigs JB, 2006, DIABETES, V55, P530, DOI 10.2337/diabetes.55.02.06.db05-1041
   Meigs JB, 2004, JAMA-J AM MED ASSOC, V291, P1978, DOI 10.1001/jama.291.16.1978
   Mertens AC, 2008, JNCI-J NATL CANCER I, V100, P1368, DOI 10.1093/jnci/djn310
   Miller KD, 2019, CA-CANCER J CLIN, V69, P363, DOI 10.3322/caac.21565
   Miranda JA, 2013, MOL CELL BIOCHEM, V372, P155, DOI 10.1007/s11010-012-1456-y
   Mitrou PN, 2007, ARCH INTERN MED, V167, P2461, DOI 10.1001/archinte.167.22.2461
   Mody R, 2008, BLOOD, V111, P5515, DOI 10.1182/blood-2007-10-117150
   Montassier E, 2015, ALIMENT PHARM THER, V42, P515, DOI 10.1111/apt.13302
   Montassier E, 2014, MICROB ECOL, V67, P690, DOI 10.1007/s00248-013-0355-4
   Morel S, 2017, J LIPID RES, V58, P982, DOI 10.1194/jlr.M072207
   Mostoufi-Moab S, 2015, J BONE MINER RES, V30, P1657, DOI 10.1002/jbmr.2512
   Munford RS, 2016, J LEUKOCYTE BIOL, V100, P687, DOI 10.1189/jlb.3RU0316-151R
   Murray RD, 2002, J CLIN ENDOCR METAB, V87, P129, DOI 10.1210/jc.87.1.129
   Nam YD, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0082659
   Nathan PC, 2016, CAN J CARDIOL, V32, P871, DOI 10.1016/j.cjca.2016.02.065
   Neville KA, 2006, J CLIN ENDOCR METAB, V91, P4401, DOI 10.1210/jc.2006-0128
   Nottage KA, 2014, BRIT J HAEMATOL, V165, P364, DOI 10.1111/bjh.12754
   NYCE J, 1989, CANCER RES, V49, P5829
   Oeffinger KC, 2003, J CLIN ONCOL, V21, P1359, DOI 10.1200/JCO.2003.06.131
   Oeffinger KC, 2001, J PEDIAT HEMATOL ONC, V23, P424, DOI 10.1097/00043426-200110000-00007
   Oeffinger KC, 2009, J CLIN ONCOL, V27, P3698, DOI 10.1200/JCO.2008.19.7251
   Oudin C, 2011, BLOOD, V117, P4442, DOI 10.1182/blood-2010-09-304899
   Papanicolas LE, 2018, TRENDS MICROBIOL, V26, P393, DOI 10.1016/j.tim.2017.10.009
   Parikh NI, 2009, OBESITY, V17, P2054, DOI 10.1038/oby.2009.60
   Parkar SG, 2013, ANAEROBE, V23, P12, DOI 10.1016/j.anaerobe.2013.07.009
   Patterson BC, 2012, J CLIN ENDOCR METAB, V97, P810, DOI 10.1210/jc.2011-2104
   Pietilä S, 2009, PEDIATR BLOOD CANCER, V52, P853, DOI 10.1002/pbc.21936
   Polovina MM, 2014, POSTGRAD MED, V126, P38, DOI 10.3810/pgm.2014.03.2739
   Pomykala KL, 2013, BRAIN IMAGING BEHAV, V7, P511, DOI 10.1007/s11682-013-9243-2
   Pui CH, 2012, BLOOD, V120, P1165, DOI 10.1182/blood-2012-05-378943
   Pusztai L, 2004, CYTOKINE, V25, P94, DOI 10.1016/j.cyto.2003.10.004
   Putze J, 2009, INFECT IMMUN, V77, P4696, DOI 10.1128/IAI.00522-09
   Rajagopala SV, 2016, BMC GENOMICS, V17, DOI 10.1186/s12864-016-2965-y
   Rajani C, 2018, CLIN SCI, V132, P791, DOI 10.1042/CS20171328
   Ramírez-Vélez R, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-3678-5
   Redan BW, 2016, ADV NUTR, V7, P1090, DOI 10.3945/an.116.013029
   Richard ML, 2019, NAT REV GASTRO HEPAT, V16, P331, DOI 10.1038/s41575-019-0121-2
   Robien K, 2008, J PEDIAT HEMATOL ONC, V30, P815, DOI 10.1097/MPH.0b013e31817e4ad9
   Rosen GP, 2013, PEDIATR BLOOD CANCER, V60, P1922, DOI 10.1002/pbc.24703
   Ross JA, 2004, J CLIN ONCOL, V22, P3558, DOI 10.1200/JCO.2004.11.152
   Ruble K, 2015, J PEDIAT HEMATOL ONC, V37, P117, DOI 10.1097/MPH.0000000000000122
   Sabico S, 2019, CLIN NUTR, V38, P1561, DOI 10.1016/j.clnu.2018.08.009
   Saghafian-Hedengren S, 2018, BLOOD REV, V32, P71, DOI 10.1016/j.blre.2017.08.009
   Sanders JE, 2009, BLOOD, V113, P306, DOI 10.1182/blood-2008-08-173005
   Sayed-Ahmed MM, 2010, OXID MED CELL LONGEV, V3, P266, DOI 10.4161/oxim.3.4.12859
   Schwingshackl L, 2015, PUBLIC HEALTH NUTR, V18, P1292, DOI 10.1017/S1368980014001542
   Scott AJ, 2018, ECANCERMEDICALSCIENC, V12, DOI 10.3332/ecancer.2018.869
   Shalitin S, 2014, HORM RES PAEDIAT, V81, P32, DOI 10.1159/000355577
   Shankar SM, 2008, PEDIATRICS, V121, pE387, DOI 10.1542/peds.2007-0575
   Siviero-Miachon AA, 2011, ARQ BRAS ENDOCRINOL, V55, P653, DOI 10.1590/S0004-27302011000800022
   Siviero-Miachon AA, 2008, VASC HEALTH RISK MAN, V4, P825
   Sofi F, 2010, AM J CLIN NUTR, V92, P1189, DOI 10.3945/ajcn.2010.29673
   Sohn Young Bae, 2011, Korean J Pediatr, V54, P253, DOI 10.3345/kjp.2011.54.6.253
   Soultati A, 2012, CANCER TREAT REV, V38, P473, DOI 10.1016/j.ctrv.2011.09.002
   Spahis S, 2017, ANTIOXID REDOX SIGN, V26, P445, DOI 10.1089/ars.2016.6756
   Tarp J, 2019, J PHYS ACT HEALTH, V16, P108, DOI 10.1123/jpah.2017-0678
   Taskinen M, 2000, LANCET, V356, P993, DOI 10.1016/S0140-6736(00)02717-3
   Tell R, 2004, INT J RADIAT ONCOL, V60, P395, DOI 10.1016/j.ijrobp.2004.03.020
   Tian T, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/4535194
   Tichelli A, 2009, EXPERT REV HEMATOL, V2, P583, DOI 10.1586/EHM.09.48
   Tonorezos ES, 2013, CANCER CAUSE CONTROL, V24, P313, DOI 10.1007/s10552-012-0116-6
   Tonorezos ES, 2012, PEDIATR BLOOD CANCER, V58, P31, DOI 10.1002/pbc.22964
   Trimis G, 2007, J PEDIAT HEMATOL ONC, V29, P309, DOI 10.1097/MPH.0b013e318059c249
   Tylavsky FA, 2010, PEDIATR BLOOD CANCER, V55, P1362, DOI 10.1002/pbc.22737
   Urakawa H, 2003, J CLIN ENDOCR METAB, V88, P4673, DOI 10.1210/jc.2003-030202
   Uzunlulu M, 2007, ENDOCR J, V54, P71, DOI 10.1507/endocrj.K06-124
   Valdes Ana M, 2018, BMJ, V361, pk2179, DOI 10.1136/bmj.k2179
   van de Wouw M, 2017, J NUTR, V147, P727, DOI 10.3945/jn.116.240481
   Van Gaal LF, 2006, NATURE, V444, P875, DOI 10.1038/nature05487
   van Vliet MJ, 2010, PLOS PATHOG, V6, DOI 10.1371/journal.ppat.1000879
   van Vliet MJ, 2009, CLIN INFECT DIS, V49, P262, DOI 10.1086/599346
   van Waas M, 2010, ANN ONCOL, V21, P1121, DOI 10.1093/annonc/mdp414
   van Waas M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0052237
   Vatanen A, 2017, BONE MARROW TRANSPL, V52, P600, DOI 10.1038/bmt.2016.334
   Veringa SJE, 2012, PEDIATR BLOOD CANCER, V58, P278, DOI 10.1002/pbc.23251
   Vivarelli F, 2018, INT J FOOD SCI NUTR, V69, P192, DOI 10.1080/09637486.2017.1350940
   Weitkunat K, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-06447-x
   Westerink MDNL, 2016, CRIT REV ONCOL HEMAT, V108, P128, DOI 10.1016/j.critrevonc.2016.10.011
   Williams AM, 2018, J NEUROIMMUNOL, V314, P17, DOI 10.1016/j.jneuroim.2017.10.005
   Wilson CL, 2015, CANCER-AM CANCER SOC, V121, P2262, DOI 10.1002/cncr.29153
   Wu GD, 2011, SCIENCE, V334, P105, DOI 10.1126/science.1208344
   Ye JP, 2013, FRONT MED-PRC, V7, P14, DOI 10.1007/s11684-013-0262-6
   Youmba SB, 2012, J PEDIATR GASTR NUTR, V54, P463, DOI 10.1097/MPG.0b013e318247240d
   Zeng H, 2015, TRENDS IMMUNOL, V36, P3, DOI 10.1016/j.it.2014.08.003
   Zhang FF, 2014, PEDIATR BLOOD CANCER, V61, P1263, DOI 10.1002/pbc.24960
   Zhang QQ, 2016, MEDICINA-LITHUANIA, V52, P28, DOI 10.1016/j.medici.2015.11.008
   Zitvogel L, 2017, NAT REV MICROBIOL, V15, P465, DOI 10.1038/nrmicro.2017.44
   Zwielehner J, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0028654
NR 199
TC 7
Z9 8
U1 0
U2 14
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD JAN 20
PY 2021
VL 34
IS 3
BP 223
EP 251
DI 10.1089/ars.2020.8102
EA JUN 2020
PG 29
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA PP0DR
UT WOS:000538177700001
PM 32390455
DA 2025-06-11
ER

PT J
AU Park, JM
   Lee, JY
   Lee, DC
   Lee, YJ
AF Park, Jae-Min
   Lee, Jee-Yon
   Lee, Duk-Chul
   Lee, Yong-Jae
TI Serum -glutamyltransferase level and metabolic syndrome in children and
   adolescents: Korean National Health and Nutrition Examination Survey
SO JOURNAL OF DIABETES INVESTIGATION
LA English
DT Article
DE -Glutamyltransferase; Childhood obesity; Metabolic syndrome
ID TYPE-2 DIABETES-MELLITUS; GAMMA-GLUTAMYL-TRANSPEPTIDASE; FATTY
   LIVER-DISEASE; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; TRANSFERASE
   LEVELS; OXIDATIVE STRESS; RISK; MEN; WOMEN
AB Aims/IntroductionSerum -glutamyltransferase (GGT) is positively related to cardiometabolic diseases, such as type 2 diabetes mellitus, hypertension and metabolic syndrome (MetS), in adult populations. Our aim was to investigate whether serum GGT is independently associated with MetS and its components in a nationally representative sample of Korean children and adolescents.
   Materials and MethodsThe study included data from 1,618 participants (867 boys, 751 girls) aged 10-18years from the 2010-2011 Korean National Health and Nutrition Examination Survey. MetS was diagnosed by the 2007 International Diabetes Federation criteria for children and adolescents. Participants were stratified using a cut-off value of the 75th percentile of serum GGT levels (19IU/L for boys, 15IU/L for girls). The odds ratios and 95% confidence intervals for MetS and its components were determined with multiple logistic regression analyses.
   ResultsThe mean values of most cardiometabolic variables were significantly higher in the upper stratum. Except for low high-density lipoprotein cholesterol in boys and elevated blood pressure in girls, participants in the upper GGT stratum had significantly higher odds of MetS and its components than those in the lower stratum. The multivariate-adjusted odds ratios for MetS for the upper stratum were 5.79 (95% confidence interval 1.21-27.02) in boys and 6.20 (95% confidence interval 1.71-22.47) in girls, after adjusting for age, household income and residential area.
   ConclusionsSerum GGT was positively associated with MetS and its components in Korean children and adolescents. Serum GGT could be a useful measure for identifying children and adolescents with MetS.
C1 [Park, Jae-Min] Konkuk Univ, Dept Family Med, Seoul, South Korea.
   [Lee, Jee-Yon] CHA Univ, CHA Bundang Med Ctr, Coll Med, Chaum Life Ctr,Dept Family Med, Seoul, South Korea.
   [Lee, Duk-Chul; Lee, Yong-Jae] Yonsei Univ, Coll Med, Dept Family Med, Seoul, South Korea.
C3 Konkuk University; Konkuk University Medical Center; Pochon Cha
   University; Yonsei University; Yonsei University Health System
RP Lee, YJ (corresponding author), Yonsei Univ, Coll Med, Dept Family Med, Seoul, South Korea.
EM ukyjhome@yuhs.ac
RI Lee, Yong Jae/GLR-4153-2022; Lee, Jee-Yon/GER-4141-2022
OI Lee, Jee-Yon/0000-0002-6376-2681; Lee, Duk Chul/0000-0001-9166-1813;
   Lee, Yong-Jae/0000-0002-6697-476X; Park, JaeMin/0000-0001-8873-8832
CR Adiels M, 2006, DIABETOLOGIA, V49, P755, DOI 10.1007/s00125-005-0125-z
   Agirbasli M, 2009, METABOLISM, V58, P1256, DOI 10.1016/j.metabol.2009.03.024
   [Anonymous], 2007 KOR CHILDR AD G
   [Anonymous], KOR NAT HLTH NUTR EX
   Böttner A, 2004, J CLIN ENDOCR METAB, V89, P4053, DOI 10.1210/jc.2004-0303
   Boyraz M, 2014, OBES RES CLIN PRACT, V8, pE356, DOI 10.1016/j.orcp.2013.08.003
   Can U, 2016, J PEDIATR ENDOCR MET, V29, P1277, DOI 10.1515/jpem-2016-0136
   Czaja AJ, 2014, CLIN GASTROENTEROL H, V12, P1430, DOI 10.1016/j.cgh.2013.08.039
   Esposito K, 2012, DIABETES CARE, V35, P2402, DOI 10.2337/dc12-0336
   Friend A, 2013, METAB SYNDR RELAT D, V11, P71, DOI 10.1089/met.2012.0122
   Garcés C, 2010, METABOLISM, V59, P166, DOI 10.1016/j.metabol.2009.06.033
   Hannuksela ML, 2007, CLIN CHEM LAB MED, V45, P953, DOI 10.1515/CCLM.2007.190
   Kikuchi A, 2017, J DIABETES INVEST, V8, P152, DOI 10.1111/jdi.12573
   Ko SH, 2015, WORLD J GASTROENTERO, V21, P7478, DOI 10.3748/wjg.v21.i24.7478
   Kong APS, 2013, PEDIATR OBES, V8, P351, DOI 10.1111/j.2047-6310.2012.00115.x
   Lee CD, 2001, AM J EPIDEMIOL, V154, P758, DOI 10.1093/aje/154.8.758
   Lee DH, 2004, FREE RADICAL RES, V38, P535, DOI 10.1080/10715760410001694026
   Lee SY, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/578693
   Liu CF, 2012, INT J CLIN PRACT, V66, P692, DOI 10.1111/j.1742-1241.2012.02959.x
   Liu CF, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048878
   Lozovoy MAB, 2013, SCAND J RHEUMATOL, V42, P303, DOI 10.3109/03009742.2012.754942
   Moran A, 1999, DIABETES, V48, P2039, DOI 10.2337/diabetes.48.10.2039
   Moriarty-Kelsey M., 2010, Childhood Obesity, V6, P250, DOI 10.1089/chi.2010.0504
   Morrison JA, 2008, J PEDIATR-US, V152, P201, DOI 10.1016/j.jpeds.2007.09.010
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Penke M, 2016, J PEDIATR ENDOCR MET, V29, P1329, DOI 10.1515/jpem-2016-0415
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Ryoo JH, 2014, DIABETIC MED, V31, P455, DOI 10.1111/dme.12315
   Seppälä-Lindroos A, 2002, J CLIN ENDOCR METAB, V87, P3023, DOI 10.1210/jc.87.7.3023
   Shin YH, 2015, SCAND J CLIN LAB INV, V75, P177, DOI 10.3109/00365513.2014.993693
   Stark AA, 2003, BIOFACTORS, V17, P139, DOI 10.1002/biof.5520170114
   Tahan V, 2008, HEPATO-GASTROENTEROL, V55, P1433
   Tiikkainen M, 2002, OBES RES, V10, P859, DOI 10.1038/oby.2002.118
   Wärnberg J, 2008, CURR OPIN LIPIDOL, V19, P11, DOI 10.1097/MOL.0b013e3282f4096b
   Whitfield JB, 2001, CRIT REV CL LAB SCI, V38, P263, DOI 10.1080/20014091084227
   Wilson PWF, 2005, CIRCULATION, V112, P3066, DOI 10.1161/CIRCULATIONAHA.105.539528
   Yasui T, 2008, CLIN CHIM ACTA, V398, P43, DOI 10.1016/j.cca.2008.08.006
   Zimmet P, 2007, PEDIATR DIABETES, V8, P299, DOI 10.1111/j.1399-5448.2007.00271.x
NR 38
TC 10
Z9 10
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2040-1124
J9 J DIABETES INVEST
JI J. Diabetes Investig.
PD MAY
PY 2018
VL 9
IS 3
BP 522
EP 528
DI 10.1111/jdi.12716
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GF1ZE
UT WOS:000431734700011
PM 28741806
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kaya, Z
   Caglayan, S
   Akkiprik, M
   Aral, C
   Ozisik, G
   Ozata, M
   Ozer, A
AF Kaya, Z.
   Caglayan, S.
   Akkiprik, M.
   Aral, C.
   Ozisik, G.
   Ozata, M.
   Ozer, A.
TI Impact of glucocorticoid receptor gene (NR3C1) polymorphisms in Turkish
   patients with metabolic syndrome
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE Metabolic syndrome; Glucocorticoid receptor gene; Glucocorticoid
ID C-REACTIVE PROTEIN; FRAGMENT-LENGTH-POLYMORPHISM; PITUITARY-ADRENAL
   AXIS; IN-VIVO; CHINESE POPULATION; ASSOCIATION; SENSITIVITY; STRESS;
   RISK; BCLI
AB Background The metabolic syndrome (MetS) is characterized by a cluster of metabolic factors, including insulin resistance and type-2 diabetes, abdominal obesity, dyslipidemia, hypertension and microalbuminuria. Impaired glucocorticoid receptor (GR) activity also plays an important role in the etiology of MetS. The objective of our study is to evaluate the effects of GR gene polymorphisms (BclI, N363S, TthIII1 and ER22/23EK) in Turkish patients with MetS.
   Materials and methods Seventy subjects with MetS and 185 healthy controls were enrolled in the study. PCR-RFLP analysis was used for genotyping. Results for each polymorphism have been verified by allele-specific oligonucleotide analysis.
   Results BclI GG genotype was significantly associated with an increased risk of MetS (p = 0.02). Also, only in women, the G allele carriers were significantly associated with higher C-peptide. T allele carriers of TthIII1 polymorphism were significantly associated with higher C-peptide, triglyceride, insulin and C-reactive protein (CRP, p value 0.048, 0.022, 0.005 and 0.022, respectively), and lower fasting blood glucose (FBG, p = 0.02). The combined carriers of BclI polymorphism G allele and TthIII1 polymorphism T allele were significantly associated with higher diastolic blood pressure in all patients, and lower FBG and postprandial blood glucose in only men. All the ER22/23EK polymorphisms coexisted with polymorphic variant of TthIII1 (p = 0.0058).
   Conclusion The presence of homozygote polymorphic variant of BclI might be good predictive markers for the disease susceptibility. The BclI and the TthIII1 polymorphism are associated with sex-specific clinical parameters. Our findings also suggest that the combination of BclI and TthIII1 polymorphisms may play a protective role in blood glucose.
C1 [Kaya, Z.; Akkiprik, M.; Ozer, A.] Marmara Univ, Sch Med, Dept Med Biol, Basibuyuk Mah,Maltepe Basibuyuk Yolu Sok 9-1, TR-34854 Istanbul, Turkey.
   [Kaya, Z.] Yuzuncu Yil Univ, Sch Med, Dept Med Biol, Van, Turkey.
   [Caglayan, S.] Istanbul Medipol Univ, Sch Med, Dept Internal Med, Div Endocrinol & Metab, Istanbul, Turkey.
   [Aral, C.] Namik Kemal Univ, Fac Arts & Sci, Dept Mol Biol, Tekirdag, Turkey.
   [Ozisik, G.] Zorlu Ctr, Mem Wellness Endocrinol & Metab, Istanbul, Turkey.
   [Ozata, M.] Parc 15 Endocrinol & Metab Clin, Istanbul, Turkey.
C3 Marmara University; Yuzuncu Yil University; Istanbul Medipol University;
   Namik Kemal University
RP Ozer, A (corresponding author), Marmara Univ, Sch Med, Dept Med Biol, Basibuyuk Mah,Maltepe Basibuyuk Yolu Sok 9-1, TR-34854 Istanbul, Turkey.
EM aozer@marmara.edu.tr
RI Akkiprik, Mustafa/AAD-6167-2020; Kaya, Zehra/AAE-8135-2020; Akkiprik,
   Mustafa/A-6453-2017
OI Akkiprik, Mustafa/0000-0002-1100-765X; Aral, Cenk/0000-0002-6044-1372;
   Kaya, Zehra/0000-0001-6222-7882
FU Scientific and Technological Research Council of Turkey (TUBITAK)
   [104S272, SBAG-K-60]; Research Foundation of Marmara University (BAPKO)
   [SAG-C-DRP-101011-0286]
FX The authors appreciate Dr. Can Erzik for his critical revision of the
   manuscript. This work was partly supported by a grant (104S272,
   SBAG-K-60 to SC) from the Scientific and Technological Research Council
   of Turkey (TUBITAK) and grants (SAG-C-DRP-101011-0286 to AO) from the
   Research Foundation of Marmara University (BAPKO).
CR Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Bachmann AW, 2005, PSYCHONEUROENDOCRINO, V30, P297, DOI 10.1016/j.psyneuen.2004.08.006
   Bray PJ, 2003, HUM MUTAT, V21, P557, DOI 10.1002/humu.10213
   Buemann B, 1997, OBES RES, V5, P186, DOI 10.1002/j.1550-8528.1997.tb00292.x
   Duan ZX, 2009, INJURY, V40, P479, DOI 10.1016/j.injury.2008.09.025
   Feng JO, 2000, AM J MED GENET, V96, P412, DOI 10.1002/1096-8628(20000612)96:3<412::AID-AJMG33>3.0.CO;2-C
   Grundy SM, 2004, ARTERIOSCL THROM VAS, V24, pE13, DOI 10.1161/01.ATV.0000111245.75752.C6
   Huizenga NATM, 1998, J CLIN ENDOCR METAB, V83, P144, DOI 10.1210/jc.83.1.144
   Ikeda Y, 2001, ENDOCR J, V48, P723, DOI 10.1507/endocrj.48.723
   Koeijvoets KCMC, 2008, J CLIN ENDOCR METAB, V93, P4902, DOI 10.1210/jc.2008-0813
   Koyano Satoru, 2005, Drug Metab Pharmacokinet, V20, P79, DOI 10.2133/dmpk.20.79
   Kumsta R, 2007, BIOL PSYCHIAT, V62, P863, DOI 10.1016/j.biopsych.2007.04.013
   Lee K, 2013, METAB SYNDR RELAT D, V11, P136, DOI 10.1089/met.2012.0098
   Lei SF, 2003, J BONE MINER METAB, V21, P34, DOI 10.1007/s007740300006
   Lin RCY, 2003, OBES RES, V11, P802, DOI 10.1038/oby.2003.111
   LOPAREV VN, 1991, J VIROL METHODS, V34, P105, DOI 10.1016/0166-0934(91)90126-K
   Mahajan A, 2012, ATHEROSCLEROSIS, V220, P275, DOI 10.1016/j.atherosclerosis.2011.10.031
   Manenschijn L, 2014, PHARMACOGENET GENOM, V24, P156, DOI 10.1097/FPC.0000000000000029
   Manenschijn L, 2009, ANN NY ACAD SCI, V1179, P179, DOI 10.1111/j.1749-6632.2009.05013.x
   Melcescu E, 2012, HORM-INT J ENDOCRINO, V11, P166, DOI 10.14310/horm.2002.1344
   Moreira RPP, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0044893
   Rosmond P, 2000, METABOLISM, V49, P1197, DOI 10.1053/meta.2000.7712
   Rosmond R, 2000, OBES RES, V8, P211, DOI 10.1038/oby.2000.24
   Rosmond R, 2002, OBES RES, V10, P1078, DOI 10.1038/oby.2002.146
   Tamashiro KL, 2011, STRESS, V14, P468, DOI 10.3109/10253890.2011.606341
   Tissing WJE, 2005, CLIN CANCER RES, V11, P6050, DOI 10.1158/1078-0432.CCR-04-2097
   Van Rossum EF, J CLIN ENDOCRINOL M, V89, P4004
   van Rossum EFC, 2002, DIABETES, V51, P3128, DOI 10.2337/diabetes.51.10.3128
   van Rossum EFC, 2004, CLIN ENDOCRINOL, V61, P573, DOI 10.1111/j.1365-2265.2004.02132.x
   van Rossum EFC, 2004, AM J MED, V117, P158, DOI 10.1016/j.amjmed.2004.01.027
   van Rossum EFC, 2003, CLIN ENDOCRINOL, V59, P585, DOI 10.1046/j.1365-2265.2003.01888.x
   WEAVER JU, 1992, J MOL ENDOCRINOL, V9, P295, DOI 10.1677/jme.0.0090295
   Yan YX, 2014, ENDOCRINE, V47, P740, DOI 10.1007/s12020-014-0324-9
   Yan YX, 2013, J EPIDEMIOL, V23, P389, DOI 10.2188/jea.JE20130035
   Zhou JG, 2005, STEROIDS, V70, P407, DOI 10.1016/j.steroids.2005.02.006
NR 35
TC 14
Z9 15
U1 0
U2 20
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD MAY
PY 2016
VL 39
IS 5
BP 557
EP 566
DI 10.1007/s40618-015-0409-1
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DJ3KB
UT WOS:000374102700010
PM 26596278
DA 2025-06-11
ER

PT J
AU Polhemus, DJ
   Bradley, JM
   Islam, KN
   Brewster, LP
   Calvert, JW
   Tao, YX
   Chang, CC
   Pipinos, II
   Goodchild, TT
   Lefer, DJ
AF Polhemus, David J.
   Bradley, Jessica M.
   Islam, Kazi N.
   Brewster, Luke P.
   Calvert, John W.
   Tao, Ya-Xiong
   Chang, Carlos C.
   Pipinos, Iraklis I.
   Goodchild, Traci T.
   Lefer, David J.
TI Therapeutic potential of sustained-release sodium nitrite for critical
   limb ischemia in the setting of metabolic syndrome
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE nitric oxide; metabolic syndrome; angiogenesis; peripheral arterial
   disease; Ossabaw swine; endothelial nitric oxide synthase; nitrite
ID PERIPHERAL ARTERIAL-DISEASE; CORONARY-HEART-DISEASE; OXIDE SYNTHASE;
   ENDOTHELIAL DYSFUNCTION; HINDLIMB ISCHEMIA; BLOOD-FLOW; ANGIOGENESIS;
   MODEL; PREVALENCE; SAFETY
AB Nitrite is a storage reservoir of nitric oxide that is readily reduced to nitric oxide under pathological conditions. Previous studies have demonstrated that nitrite levels are significantly reduced in cardiovascular disease states, including peripheral vascular disease. We investigated the cytoprotective and proangiogenic actions of a novel, sustained-release formulation of nitrite (SR-nitrite) in a clinically relevant in vivo swine model of critical limb ischemia (CLI) involving central obesity and metabolic syndrome. CLI was induced in obese Ossabaw swine (n = 18) by unilateral external iliac artery deployment of a full cross-sectional vessel occlusion device positioned within an endovascular expanded polytetrafluoroethylene-lined nitinol stent-graft. At post-CLI day 14, pigs were randomized to placebo (n = 9) or SR-nitrite (80 mg, n = 9) twice daily by mouth for 21 days. SR-nitrite therapy increased nitrite, nitrate, and S-nitrosothiol in plasma and ischemic skeletal muscle. Oxidative stress was reduced in ischemic limb tissue of SR-nitrite- compared with placebo-treated pigs. Ischemic limb tissue levels of proangiogenic growth factors were increased following SR-nitrite therapy compared with placebo. Despite the increases in cytoprotective and angiogenic signals with SR-nitrite therapy, new arterial vessel formation and enhancement of blood flow to the ischemic limb were not different from placebo. Our data clearly demonstrate cytoprotective and proangiogenic signaling in ischemic tissues following SR-nitrite therapy in a very severe model of CLI. Further studies evaluating longer-duration nitrite therapy and/or additional nitrite dosing strategies are warranted to more fully evaluate the therapeutic potential of nitrite therapy in peripheral vascular disease.
C1 [Polhemus, David J.; Bradley, Jessica M.; Islam, Kazi N.; Goodchild, Traci T.; Lefer, David J.] LSU Hlth Sci Ctr, Cardiovasc Ctr Excellence, New Orleans, LA 70112 USA.
   [Polhemus, David J.; Bradley, Jessica M.; Islam, Kazi N.; Goodchild, Traci T.; Lefer, David J.] LSU Hlth Sci Ctr, Dept Pharmacol, New Orleans, LA 70112 USA.
   [Brewster, Luke P.; Calvert, John W.] Emory Univ, Sch Med, Dept Surg, Atlanta, GA 30322 USA.
   [Brewster, Luke P.] Atlanta Vet Affairs Med Ctr, Surg & Res Serv, Decatur, GA USA.
   [Brewster, Luke P.] Georgia Inst Technol, Parker H Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA.
   [Tao, Ya-Xiong] Auburn Univ, Coll Vet Med, Dept Anat Physiol & Pharmacol, Auburn, AL 36849 USA.
   [Chang, Carlos C.] Emory Univ, Labs T3, Atlanta, GA 30322 USA.
   [Pipinos, Iraklis I.] Univ Nebraska, Med Ctr, Dept Cellular & Integrat Physiol, Omaha, NE USA.
C3 Louisiana State University System; Louisiana State University Health
   Sciences Center New Orleans; Louisiana State University System;
   Louisiana State University Health Sciences Center New Orleans; Emory
   University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Atlanta VA Health Care System; University System
   of Georgia; Georgia Institute of Technology; Auburn University System;
   Auburn University; Emory University; University of Nebraska System;
   University of Nebraska Medical Center
RP Lefer, DJ (corresponding author), LSU Hlth Sci Ctr, Cardiovasc Ctr Excellence, 533 Bolivar St,Suite 408, New Orleans, LA 70112 USA.
EM dlefe1@lsuhsc.edu
RI Lefer, David/A-6372-2012; Tao, Ya-Xiong/K-4939-2019; Calvert,
   John/F-4497-2014
OI Tao, Ya-Xiong/0000-0003-4737-749X; Pipinos, Iraklis/0000-0001-6873-6346;
   Lefer, David/0000-0003-2293-7278; Calvert, John/0000-0001-6858-6042
FU National Heart, Lung, and Blood Institute [1R01 HL-092141, 1R01
   HL-093579, 1U24 HL-094373, 1P20 HL-113452, 1K08 HL-119592]; National
   Center for Advancing Translational Sciences Clinical and Translational
   Science Award Program [UL1 TR-000454]; American Heart Association Grant
   [13IRG14740001]; Carlyle Fraser Heart Center at Emory University Midtown
   Hospital; Emory University Department of Surgery; LSU Medical School
   Alumni Association; American Heart Association (AHA) [13IRG14740001]
   Funding Source: American Heart Association (AHA)
FX This work was supported by National Heart, Lung, and Blood Institute
   Grants 1R01 HL-092141, 1R01 HL-093579, 1U24 HL-094373, and 1P20
   HL-113452 (to D. J. Lefer) and 1K08 HL-119592 (to L. P. Brewster) and in
   part by National Center for Advancing Translational Sciences Clinical
   and Translational Science Award Program Grant UL1 TR-000454 (to L. P.
   Brewster) and American Heart Association Grant 13IRG14740001 (to L. P.
   Brewster). Generous funding was provided by the Carlyle Fraser Heart
   Center at Emory University Midtown Hospital, the Emory University
   Department of Surgery, and the LSU Medical School Alumni Association.
CR Amin A, 2012, PFLUG ARCH EUR J PHY, V464, P583, DOI 10.1007/s00424-012-1167-y
   Annex BH, 2013, NAT REV CARDIOL, V10, P387, DOI 10.1038/nrcardio.2013.70
   Bell LN, 2010, AM J PHYSIOL-GASTR L, V298, pG746, DOI 10.1152/ajpgi.00485.2009
   Bender SB, 2009, EXP BIOL MED, V234, P683, DOI 10.3181/0812-RM-350
   Berwick ZC, 2012, J MOL CELL CARDIOL, V52, P912, DOI 10.1016/j.yjmcc.2011.07.004
   Bhushan S, 2014, CIRC RES, V114, P1281, DOI 10.1161/CIRCRESAHA.114.301475
   Bir SC, 2014, DIABETES, V63, P270, DOI 10.2337/db13-0890
   Boger RH, 1997, CIRCULATION, V95, P2068, DOI 10.1161/01.CIR.95.8.2068
   Brevetti LS, 2003, J VASC SURG, V38, P820, DOI 10.1016/S0741-5214(03)00555-X
   Bryan NS, 2008, FREE RADICAL BIO MED, V45, P468, DOI 10.1016/j.freeradbiomed.2008.04.040
   Cai H, 2000, CIRC RES, V87, P840, DOI 10.1161/01.RES.87.10.840
   Cao RH, 2003, NAT MED, V9, P604, DOI 10.1038/nm848
   Christoffersen B, 2013, OBESITY, V21, P149, DOI 10.1002/oby.20249
   Cooke JP, 2002, CIRCULATION, V105, P2133, DOI 10.1161/01.CIR.0000014928.45119.73
   Cosby K, 2003, NAT MED, V9, P1498, DOI 10.1038/nm954
   Couffinhal T, 1998, AM J PATHOL, V152, P1667
   Davignon J, 2004, CIRCULATION, V109, P27, DOI 10.1161/01.CIR.0000131515.03336.f8
   Duranski MR, 2005, J CLIN INVEST, V115, P1232, DOI 10.1172/JCI200522493
   Gorter PM, 2004, ATHEROSCLEROSIS, V173, P363, DOI 10.1016/j.atherosclerosis.2003.12.033
   JACOBSSON L, 1989, ARTERY, V16, P105
   Jude EB, 2001, DIABETES CARE, V24, P1433, DOI 10.2337/diacare.24.8.1433
   KANNER J, 1991, ARCH BIOCHEM BIOPHYS, V289, P130, DOI 10.1016/0003-9861(91)90452-O
   Kevil CG, 2011, FREE RADICAL BIO MED, V51, P576, DOI 10.1016/j.freeradbiomed.2011.04.042
   King AL, 2014, P NATL ACAD SCI USA, V111, P3182, DOI 10.1073/pnas.1321871111
   Kumar D, 2008, P NATL ACAD SCI USA, V105, P7540, DOI 10.1073/pnas.0711480105
   Lassaletta AD, 2012, BASIC RES CARDIOL, V107, DOI 10.1007/s00395-012-0243-y
   Lloyd PG, 2001, AM J PHYSIOL-HEART C, V281, pH2528, DOI 10.1152/ajpheart.2001.281.6.H2528
   LOSCALZO J, 1995, PROG CARDIOVASC DIS, V38, P87, DOI 10.1016/S0033-0620(05)80001-5
   Lundberg JO, 2008, NAT REV DRUG DISCOV, V7, DOI [10.1038/nrd2466-c2, 10.1038/nrd2466]
   Milsom AB, 2010, NITRIC OXIDE-BIOL CH, V22, P141, DOI 10.1016/j.niox.2009.10.010
   Mohler ER, 2014, VASC MED, V19, P9, DOI 10.1177/1358863X13515043
   Murohara T, 1998, J CLIN INVEST, V101, P2567, DOI 10.1172/JCI1560
   Nicholson CK, 2013, J MOL CELL CARDIOL, V64, P1, DOI 10.1016/j.yjmcc.2013.08.002
   Olijhoek JK, 2004, EUR HEART J, V25, P342, DOI 10.1016/j.ehj.2003.12.007
   Pluta RM, 2005, JAMA-J AM MED ASSOC, V293, P1477, DOI 10.1001/jama.293.12.1477
   Powell RJ, 2008, CIRCULATION, V118, P58, DOI 10.1161/CIRCULATIONAHA.107.727347
   Rassaf T, 2014, CIRC RES, V114, P1601, DOI 10.1161/CIRCRESAHA.114.303822
   Saito T, 2013, FEBS LETT, V587, P2179, DOI 10.1016/j.febslet.2013.05.038
   SEIFERT FC, 1985, J CARDIOVASC SURG, V26, P502
   Selvin E, 2004, CIRCULATION, V110, P738, DOI 10.1161/01.CIR.0000137913.26087.F0
   Sindler AL, 2011, AGING CELL, V10, P429, DOI 10.1111/j.1474-9726.2011.00679.x
   TAKESHITA S, 1994, J CLIN INVEST, V93, P662, DOI 10.1172/JCI117018
   TASC Working Group, 2000, EUR J VASC ENDOVASC, V19, pS1
   Vincent KA, 2000, CIRCULATION, V102, P2255
   Yu J, 2005, P NATL ACAD SCI USA, V102, P10999, DOI 10.1073/pnas.0501444102
NR 45
TC 16
Z9 17
U1 0
U2 4
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD JUL 1
PY 2015
VL 309
IS 1
BP H82
EP H92
DI 10.1152/ajpheart.00115.2015
PG 11
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA CM2IG
UT WOS:000357502700008
PM 25910804
OA Green Published
DA 2025-06-11
ER

PT J
AU Lee, MJ
   Jung, CH
   Kang, YM
   Hwang, JY
   Jang, JE
   Leem, J
   Park, JY
   Kim, HK
   Lee, WJ
AF Lee, M. J.
   Jung, C. H.
   Kang, Y. M.
   Hwang, J. Y.
   Jang, J. E.
   Leem, J.
   Park, J. -Y.
   Kim, H. -K.
   Lee, W. J.
TI Serum bilirubin as a predictor of incident metabolic syndrome: A 4-year
   retrospective longitudinal study of 6205 initially healthy Korean men
SO DIABETES & METABOLISM
LA English
DT Article
DE Bilirubin; Metabolic syndrome; Antioxidant
ID CARDIOVASCULAR-DISEASE; ANTIOXIDANT; ADULTS; RISK
AB Aim. - Serum bilirubin is an endogenous antioxidant with anti-inflammatory properties. Several cross-sectional studies have reported that bilirubin was negatively associated with oxidative stress-mediated diseases, including the metabolic syndrome (MetS). However, the clinical relevance of bilirubin as a risk factor for incident MetS remains controversial. For this reason, the longitudinal effects of baseline serum bilirubin concentrations on incident MetS were evaluated in Korean men.
   Methods. This 4-year retrospective longitudinal observational study involved 6205 Korean men without MetS. Subjects underwent routine health examinations in 2007 and returned for a follow-up examination in 2011. Baseline serum bilirubin concentrations were determined using the vanadate oxidation method.
   Results. During the 4-year period, 936 cases of incident MetS (15.1%) were identified. Its incidence decreased across baseline bilirubin quartile categories (P<0.001), with an odds ratio (OR) for developing MetS being significantly lower in the highest quartile group (>= 1.40 mg/dL) compared with the lowest (<= 0.90 mg/dL) after adjusting for all confounding variables [OR = 0.70,95% confidence interval (CI) 0.54-0.90; P for trend = 0.019]. Among individual components of MetS, bilirubin was found to be negatively associated with only the risk of incident hypertriglyceridaemia. The OR (95% CI) for incident hypertriglyceridaemia in the highest vs lowest quartile was 0.75 (0.61-0.91; P for trend = 0.002).
   Conclusion. Serum total bilirubin level was negatively associated with incidence of MetS in healthy Korean men over a 4-year period. (C) 2014 Elsevier Masson SAS. All rights reserved.
C1 [Lee, M. J.; Jung, C. H.; Kang, Y. M.; Jang, J. E.; Leem, J.; Park, J. -Y.; Lee, W. J.] Univ Ulsan Coll Med, Dept Internal Med, Asan Med Ctr, Seoul, South Korea.
   [Hwang, J. Y.; Kim, H. -K.] Univ Ulsan Coll Med, Dept Hlth Screening & Promot Ctr, Asan Med Ctr, Seoul, South Korea.
C3 University of Ulsan; Asan Medical Center; University of Ulsan; Asan
   Medical Center
RP Lee, WJ (corresponding author), Univ Ulsan Coll Med, Dept Internal Med, Asan Med Ctr, Seoul, South Korea.
EM lwjatlas@naver.com
RI Jung, Chang/AAU-7897-2020; Leem, Jaechan/AAQ-6648-2020; Kang,
   Yu/AAW-2935-2020; Jeong, Young-Hoon/F-3476-2015
OI Jung, Chang Hee/0000-0003-4043-2396; Leem, Jaechan/0000-0003-2329-4374
CR ARIAS IM, 1966, MEDICINE, V45, P513, DOI 10.1097/00005792-196645060-00015
   Bulmer AC, 2013, PROG LIPID RES, V52, P193, DOI 10.1016/j.plipres.2012.11.001
   Choi SH, 2013, NUTR METAB CARDIOVAS, V23, P31, DOI 10.1016/j.numecd.2011.03.001
   Djoussé L, 2001, AM J CARDIOL, V87, P1196, DOI 10.1016/S0002-9149(01)01494-1
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hwang HJ, 2010, CLIN CHIM ACTA, V411, P1496, DOI 10.1016/j.cca.2010.06.003
   Jo J, 2011, ENDOCRINE, V39, P182, DOI 10.1007/s12020-010-9417-2
   Jung CH, 2014, METABOLISM, V63, P87, DOI 10.1016/j.metabol.2013.09.011
   Oda E, 2013, ACTA DIABETOL, V50, P417, DOI 10.1007/s00592-012-0447-5
   Ohnaka K, 2010, DIABETES RES CLIN PR, V88, P103, DOI 10.1016/j.diabres.2009.12.022
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Rutter MK, 2004, CIRCULATION, V110, P380, DOI 10.1161/01.CIR.0000136581.59584.0E
   Schwertner HA, 1998, ATHEROSCLEROSIS, V136, P383, DOI 10.1016/S0021-9150(97)00232-3
   STOCKER R, 1987, SCIENCE, V235, P1043, DOI 10.1126/science.3029864
   Swift DL, 2012, MED SCI SPORT EXER, V44, P569, DOI 10.1249/MSS.0b013e3182357dd4
NR 15
TC 40
Z9 41
U1 0
U2 14
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 1262-3636
EI 1878-1780
J9 DIABETES METAB
JI Diabetes Metab.
PD SEP
PY 2014
VL 40
IS 4
BP 305
EP 309
DI 10.1016/j.diabet.2014.04.006
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AQ8MB
UT WOS:000343078500010
PM 24951082
DA 2025-06-11
ER

PT J
AU Lind, L
   Wohlin, M
   Andren, B
   Sundström, J
AF Lind, Lars
   Wohlin, Martin
   Andren, Bertil
   Sundstrom, Johan
TI The echogenicity of the intimamedia complex in the common carotid artery
   is related to insulin resistance measured by the hyperinsulinemic clamp
   in elderly men
SO CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING
LA English
DT Article
DE carotid artery; insulin resistance; metabolic syndrome; obesity;
   ultrasound
ID INDEPENDENT PREDICTOR; METABOLIC SYNDROME; MEDIA THICKNESS;
   MYOCARDIAL-INFARCTION; OXIDATIVE STRESS; RISK; ULTRASOUND; MORTALITY;
   ECHOGENECITY; INFLAMMATION
AB The echogenicity of the intimamedia complex (IM-GSM) has recently been shown to be related to the echogenicity in carotid artery plaque and to predict cardiovascular (CV) mortality. The present study aims to evaluate the relationship between metabolic CV risk factors, with special emphasis on insulin resistance, and IM-GSM in the carotid artery. Carotid artery ultrasound with grey-scale median analysis of the intimamedia complex, IM-GSM, was performed in a population sample of 480 men aged 75years. In these subjects, a euglycemic hyperinsulinemic clamp to investigate insulin resistance was performed together with measurements of conventional CV risk factors at the age of 70. The metabolic syndrome (MetS) was defined by the NCEP/ATPIII-criteria. In univariate analysis, IM-GSM in the common carotid artery was inversely correlated with the intimamedia thickness (IMT), body mass index (BMI), waist/hip ratio, fasting glucose, serum triglycerides, low HDL cholesterol and insulin resistance at the clamp (r=0 center dot 24, P<0 center dot 001). In multiple regression analysis, only insulin resistance at the clamp and BMI were independently related to IM-GSM. Subjects with the MetS (22%) showed a reduced IM-GSM when compared to those without (64 +/- 20 SD versus 68 +/- 19, P<0 center dot 05). Because the echogenicity of the intimamedia complex in the carotid artery is related to obesity and insulin resistance at clamp independently of IMT, this new vascular characteristic would serve as a marker of vascular alterations induced by insulin resistance and the MetS and has the advantage to be obtainable in almost all subjects.
C1 [Lind, Lars; Sundstrom, Johan] Uppsala Univ, Dept Med, S-75185 Uppsala, Sweden.
   [Wohlin, Martin] Uppsala Univ, Dept Geriatr, S-75185 Uppsala, Sweden.
   [Andren, Bertil] Uppsala Univ, Dept Clin Physiol, S-75185 Uppsala, Sweden.
C3 Uppsala University; Uppsala University; Uppsala University
RP Lind, L (corresponding author), Uppsala Univ, Dept Med Sci, S-75185 Uppsala, Sweden.
EM lars.lind@medsci.uu.se
RI Lind, Lars/KAM-1968-2024; Sundström, Johan/IAP-6197-2023
OI Sundstrom, Johan/0000-0003-2247-8454
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Andersson J, 2009, ATHEROSCLEROSIS, V204, P612, DOI 10.1016/j.atherosclerosis.2008.10.038
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   DEFRONZO RA, 1979, AM J PHYSIOL, V237, pE214
   ElBarghouty NM, 1996, EUR J VASC ENDOVASC, V11, P414, DOI 10.1016/S1078-5884(96)80172-9
   Fosse E, 2006, ULTRASOUND MED BIOL, V32, P3, DOI 10.1016/j.ultrasmedbio.2005.09.006
   Gonçalves I, 2004, STROKE, V35, P2795, DOI 10.1161/01.STR.0000147038.12073.59
   GRAYWEALE AC, 1988, J CARDIOVASC SURG, V29, P676
   Ingelsson E, 2005, JAMA-J AM MED ASSOC, V294, P334, DOI 10.1001/jama.294.3.334
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Liang Q, 2000, IEEE T MED IMAGING, V19, P127, DOI 10.1109/42.836372
   Lind L, 2006, ARTERIOSCL THROM VAS, V26, P406, DOI 10.1161/01.ATV.0000197827.12431.d0
   Lind L, 2008, LIPIDS, V43, P133, DOI 10.1007/s11745-007-3125-6
   Lind L, 2007, ATHEROSCLEROSIS, V195, P411, DOI 10.1016/j.atherosclerosis.2007.03.029
   Mathiesen EB, 2001, CIRCULATION, V103, P2171
   O'Leary DH, 1999, NEW ENGL J MED, V340, P14, DOI 10.1056/NEJM199901073400103
   Reaven GM, 1996, NEW ENGL J MED, V334, P374, DOI 10.1056/NEJM199602083340607
   Schmidt C, 2005, ATHEROSCLEROSIS, V181, P125, DOI 10.1016/j.atherosclerosis.2004.12.034
   Spence JD, 2002, STROKE, V33, P2916, DOI 10.1161/01.STR.0000042207.16156.B9
   Sundström J, 2006, BMJ-BRIT MED J, V332, P878, DOI 10.1136/bmj.38766.624097.1F
   Sundström J, 2000, CIRCULATION, V101, P2595, DOI 10.1161/01.CIR.101.22.2595
   Wohlin M, 2007, CYTOKINE, V38, P130, DOI 10.1016/j.cyto.2007.05.014
   Wohlin M, 2003, ATHEROSCLEROSIS, V170, P181, DOI 10.1016/S0021-9150(03)00283-1
   Wohlin M, 2009, ATHEROSCLEROSIS, V205, P486, DOI 10.1016/j.atherosclerosis.2009.01.032
   Zethelius B, 2002, CIRCULATION, V105, P2153, DOI 10.1161/01.CIR.0000015855.04844.E7
NR 25
TC 11
Z9 13
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1475-0961
EI 1475-097X
J9 CLIN PHYSIOL FUNCT I
JI Clin. Physiol. Funct. Imaging
PD MAR
PY 2013
VL 33
IS 2
BP 137
EP 142
DI 10.1111/cpf.12006
PG 6
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 086BQ
UT WOS:000314658400008
PM 23383692
DA 2025-06-11
ER

PT J
AU Relf, BL
   Larkin, EK
   De Torres, C
   Baur, LA
   Christodoulou, J
   Waters, KA
AF Relf, Bronwyn L.
   Larkin, Emma K.
   De Torres, Carina
   Baur, Louise A.
   Christodoulou, John
   Waters, Karen A.
TI Genome-wide linkage of obstructive sleep apnoea and high-density
   lipoprotein cholesterol in a Filipino family: bivariate linkage analysis
   of obstructive sleep apnoea
SO JOURNAL OF SLEEP RESEARCH
LA English
DT Article
DE bivariate; gene; inflammation; metabolic syndrome; obesity; respiratory
   disturbance index
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; SUSCEPTIBILITY LOCUS;
   AFRICAN-AMERICAN; RISK-FACTORS; T-CELLS; SCAN; ASSOCIATION;
   INFLAMMATION; CHILDREN
AB P>Increasing evidence supports an association between obstructive sleep apnoea (OSA) and metabolic syndrome (MeS) in both children and adults, suggesting a genetic component. However, the genetic relationship between the diseases remains unclear. We performed a bivariate linkage scan on a single Filipino family with a high prevalence of OSA and MeS to explore the genetic pathways underlying these diseases. A large rural family (n = 50, 50% adults) underwent a 10-cM genome-wide scan. Fasting blood was used to measure insulin, triglycerides, total cholesterol and high density lipoprotein (HDL) cholesterol. Attended overnight polysomnography was used to quantify the respiratory disturbance index (RDI), a measure of sleep apnoea. Body mass index z-scores and insulin resistance scores were calculated. Bivariate multipoint linkage analyses were performed on RDI and MeS components. OSA prevalence was 46% (n = 23; nine adults, 14 children) in our participants. MeS phenotype was present in 40% of adults (n = 10) and 48% of children (n = 12). Linkage peaks with a logarithm of odds (LOD) score > 3 were demonstrated on chromosome 19q13.4 (LOD = 3.04) for the trait pair RDI and HDL cholesterol. Candidate genes identified in this region include the killer cell immunoglobulin-like receptor genes. These genes are associated with modulating inflammatory responses in reaction to cellular stress and initiation of atherosclerotic plaque formation. We have identified a novel locus for genetic links between RDI and lipid factors associated with MeS in a chromosomal region containing genes associated with inflammatory responses.
C1 [Relf, Bronwyn L.; Baur, Louise A.; Christodoulou, John; Waters, Karen A.] Univ Sydney, Discipline Paediat & Child Hlth, Sydney, NSW 2006, Australia.
   [Larkin, Emma K.] Case Western Reserve Univ, Ctr Clin Invest, Cleveland, OH 44106 USA.
   [Christodoulou, John] Childrens Hosp Westmead, Western Sydney Genet Program, Sydney, NSW, Australia.
   [Waters, Karen A.] Childrens Hosp Westmead, Resp Support Serv, Sydney, NSW, Australia.
C3 University of Sydney; University System of Ohio; Case Western Reserve
   University; NSW Health; The Children's Hospital at Westmead; University
   of Sydney; University of Sydney; NSW Health; The Children's Hospital at
   Westmead
RP Waters, KA (corresponding author), Childrens Hosp, Dept Resp Med, Locked Bag 4001, Westmead, NSW 2145, Australia.
EM karenw2@chw.edu.au
RI Christodoulou, John/E-5866-2015; Waters, Karen/B-2840-2013; Baur,
   Louise/AAE-3413-2021; Christodoulou, John/M-3628-2019
OI Baur, Louise/0000-0002-4521-9482; Christodoulou,
   John/0000-0002-8431-0641; Waters, Karen/0000-0001-8699-2175
FU NHLBL [HL070784]; NHMRC [249403]; NIH [KL2-RR024990]; National Center
   for Research
FX We thank Rose White for performing the DNA extractions, and Sherryn
   Bailey for monitoring and scoring the sleep studies. Funding source:
   NHLBL HL070784 (K. A. W.), NHMRC 249403 (K. A. W.) and NIH: KL2-RR024990
   (E. K. L.). Some of the results of this paper were obtained by using the
   software package S. A. G. E., which is supported by a U. S. Public
   Health Service Resource Grant from the National Center for Research.
CR Almasy L, 1997, GENET EPIDEMIOL, V14, P953, DOI 10.1002/(SICI)1098-2272(1997)14:6<953::AID-GEPI65>3.0.CO;2-K
   Almasy L, 1998, AM J HUM GENET, V62, P1198, DOI 10.1086/301844
   American Academy of Sleep Medicine, 2001, ICSD INT CLASS SLEEP
   Amos CI, 2001, HUM HERED, V51, P133, DOI 10.1159/000053334
   An P, 2005, DIABETES, V54, P909, DOI 10.2337/diabetes.54.3.909
   [Anonymous], 2012, Molecular cloning: a laboratory manual
   Araneta MRG, 2007, OBESITY, V15, P2454, DOI 10.1038/oby.2007.291
   Araneta MRG, 2002, DIABETES CARE, V25, P494, DOI 10.2337/diacare.25.3.494
   Bell CG, 2004, DIABETES, V53, P1857, DOI 10.2337/diabetes.53.7.1857
   *CAS W RES U, 2007, SAGE STAT AN GEN EP, V4, P1
   Chiu YF, 2005, DIABETES, V54, P1200, DOI 10.2337/diabetes.54.4.1200
   Coughlin SR, 2004, EUR HEART J, V25, P735, DOI 10.1016/j.ehj.2004.02.021
   de la Eva RC, 2002, J PEDIATR-US, V140, P654, DOI 10.1067/mpd.2002.123765
   Dyugovskaya L, 2005, EUR RESPIR J, V25, P820, DOI 10.1183/09031936.05.00103204
   Dyugovskaya L, 2003, AM J RESP CRIT CARE, V168, P242, DOI 10.1164/rccm.200210-1226OC
   Elbein SC, 2002, DIABETES, V51, P528, DOI 10.2337/diabetes.51.2.528
   Gottlieb DJ, 2007, BMC MED GENET, V8, DOI 10.1186/1471-2350-8-S1-S9
   Gozal D, 2008, SLEEP MED, V9, P254, DOI 10.1016/j.sleep.2007.04.013
   Ip MSM, 2002, AM J RESP CRIT CARE, V165, P670, DOI 10.1164/ajrccm.165.5.2103001
   Jacobs R, 2001, EUR J IMMUNOL, V31, P3121, DOI 10.1002/1521-4141(2001010)31:10<3121::AID-IMMU3121>3.0.CO;2-4
   Kano M, 2007, CHEST, V131, P1387, DOI 10.1378/chest.06-1807
   Kelley J, 2005, PLOS GENET, V1, P129, DOI 10.1371/journal.pgen.0010027
   KHALYFA A, 2008, SLEEP MED, V10, P66
   Lam B, 2007, INT J TUBERC LUNG D, V11, P2
   Lambert M, 2004, INT J OBESITY, V28, P833, DOI 10.1038/sj.ijo.0802694
   Larkin EK, 2008, ANN HUM GENET, V72, P762, DOI 10.1111/j.1469-1809.2008.00472.x
   Larkin EK, 2006, GENET EPIDEMIOL, V30, P101, DOI 10.1002/gepi.20127
   Larkin EK, 2005, CIRCULATION, V111, P1978, DOI 10.1161/01.CIR.0000161819.76138.5E
   Lavie L, 2003, SLEEP MED REV, V7, P35, DOI 10.1053/smrv.2002.0261
   Loos RJF, 2003, J CLIN ENDOCR METAB, V88, P5935, DOI 10.1210/jc.2003-030553
   Malhotra A, 2007, DIABETES, V56, P890, DOI 10.2337/db06-1057
   Martin LJ, 2004, OBES RES, V12, P669, DOI 10.1038/oby.2004.77
   McArdle N, 2007, AM J RESP CRIT CARE, V175, P190, DOI 10.1164/rccm.200602-270OC
   Morales DD, 2008, DIABETES VASC DIS RE, V5, P36, DOI 10.3132/dvdr.2008.007
   Ng MCY, 2004, DIABETES, V53, P2676, DOI 10.2337/diabetes.53.10.2676
   Nock NL, 2009, SLEEP, V32, P615, DOI 10.1093/sleep/32.5.615
   Palmer LJ, 2004, AM J RESP CRIT CARE, V169, P1314, DOI 10.1164/rccm.200304-493OC
   Palmer LJ, 2003, AM J HUM GENET, V72, P340, DOI 10.1086/346064
   Patel SR, 2005, J APPL PHYSIOL, V99, P1600, DOI 10.1152/japplphysiol.00501.2005
   Peled N, 2007, RESP MED, V101, P1696, DOI 10.1016/j.rmed.2007.02.025
   Redline S, 2007, AM J RESP CRIT CARE, V176, P401, DOI 10.1164/rccm.200703-375OC
   Saar K, 2003, PEDIATRICS, V111, P321, DOI 10.1542/peds.111.2.321
   Sasanabe R, 2006, HYPERTENS RES, V29, P315, DOI 10.1291/hypres.29.315
   Srinivasan SR, 2006, HYPERTENSION, V48, P33, DOI 10.1161/01.HYP.0000226410.11198.f4
   Tam CS, 2006, J PAEDIATR CHILD H, V42, P277, DOI 10.1111/j.1440-1754.2006.00854.x
   Trowsdale J, 2001, IMMUNOL REV, V181, P20, DOI 10.1034/j.1600-065X.2001.1810102.x
   Uhrberg M, 2001, J IMMUNOL, V166, P3923, DOI 10.4049/jimmunol.166.6.3923
   van Tilburg JHO, 2003, J CLIN ENDOCR METAB, V88, P2223, DOI 10.1210/jc.2002-021252
   Villaneuva ATC, 2005, SLEEP MED REV, V9, P419, DOI 10.1016/j.smrv.2005.04.005
   Waters KA, 2007, J SLEEP RES, V16, P388, DOI 10.1111/j.1365-2869.2007.00614.x
   WHO, 2004, LANCET, V363, P902, DOI 10.1016/S0140-6736(03)15268-3
   *WHO, 1999, WHONCDNCS992 DEP NON
NR 52
TC 11
Z9 12
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1105
EI 1365-2869
J9 J SLEEP RES
JI J. Sleep Res.
PD JUN
PY 2010
VL 19
IS 2
BP 349
EP 357
DI 10.1111/j.1365-2869.2009.00797.x
PG 9
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 597UB
UT WOS:000277786300012
PM 20149069
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Wu, YY
   Xu, GQ
   Bai, RX
   Yu, PP
   He, ZX
   Chen, MX
   Hu, YK
   Jiang, T
   Yang, YH
   Liu, DF
   Mei, Y
   Qi, XY
   Cheng, FF
AF Wu, Yuanyuan
   Xu, Guoqiong
   Bai, Ruixue
   Yu, Pingping
   He, Zhongxiang
   Chen, Mengxue
   Hu, Yukun
   Jiang, Tao
   Yang, Yuanhang
   Liu, Dongfang
   Mei, Ying
   Qi, Xiaoya
   Cheng, Feifei
TI Association Between Circulating Zinc Levels and Risk Factors of
   Metabolic Syndrome: Insights from a Bi-directional Mendelian
   Randomization Analysis and Cross-Sectional Study
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Zinc; Metabolic syndrome; Lipids; Obesity; Mendelian randomization
ID INSULIN-RESISTANCE; SERUM ZINC; OXIDATIVE STRESS; SUPPLEMENTATION; MEN;
   MICRONUTRIENT; INFLAMMATION; COMPONENTS; MAGNESIUM; PEOPLE
AB Previous studies on the relationship between zinc and metabolic syndrome (MetS) have yielded inconsistent results. This comprehensive study aimed to elaborately explore the impact of zinc on MetS risk factors. The bi-directional Mendelian randomization (MR) analyses were performed to estimate the causal relationship between zinc and MetS risk factors. Additionally, a retrospective cross-sectional study incorporated 4389 subjects to provide a broader perspective in conjunction with the MR analyses. In the MR analyses, genetically instrumented zinc was positively associated with five of the MetS components in Europeans, including BMI, FBG, HbA1c, TC, and LDL-c (beta (95%CI) = 0.023 (0.019-0.027), 0.019 (0.013-0.025), 0.041 (0.022-0.060), 0.027 (0.013-0.042), and 0.018 (0.010-0.026), respectively). In the cross-sectional study, higher concentration of zinc was strongly associated with increased BMI, LDL-c, and UA (beta (95%CI) = 0.040 (0.010-0.085), 0.026 (0.018-0.035), and 1.529 (0.614-2.445), respectively). Moreover, these unfavorable associations were more obvious in women compared to men, with a borderline significant interaction effect for BMI (P=0.051). Our study showed that higher blood concentration of zinc, an essential trace element, was associated with unfavorable changes of the component metabolic risk factors of MetS, especially with BMI and LDL-c. Notably, these associations seemed to be more pronounced in women rather than in men. Further studies are warranted to elucidate the role of zinc status in the underlying mechanisms of MetS.
C1 [Wu, Yuanyuan; Xu, Guoqiong; Bai, Ruixue; Yu, Pingping; He, Zhongxiang; Chen, Mengxue; Hu, Yukun; Jiang, Tao; Yang, Yuanhang; Mei, Ying; Qi, Xiaoya; Cheng, Feifei] Chongqing Med Univ, Affiliated Hosp 2, Hlth Management Ctr, Chongqing, Peoples R China.
   [Liu, Dongfang] Chongqing Med Univ, Affiliated Hosp 2, Dept Endocrinol & Metab, Chongqing, Peoples R China.
C3 Chongqing Medical University; Chongqing Medical University
RP Qi, XY; Cheng, FF (corresponding author), Chongqing Med Univ, Affiliated Hosp 2, Hlth Management Ctr, Chongqing, Peoples R China.
EM qixiaoya66@cqmu.edu.cn; feifeicheng@hospital.cqmu.edu.cn
RI JIANG, TAO/AAU-5948-2020
FU We would like to acknowledge participants involved in this study. We
   also appreciate the efforts of physicians and nurses in the Department
   of Health Management Center of the Second Affiliated Hospital of
   Chongqing Medical University.; Department of Health Management Center of
   the Second Affiliated Hospital of Chongqing Medical University
FX We would like to acknowledge participants involved in this study. We
   also appreciate the efforts of physicians and nurses in the Department
   of Health Management Center of the Second Affiliated Hospital of
   Chongqing Medical University.
CR Ahn BI, 2014, BIOL TRACE ELEM RES, V160, P169, DOI 10.1007/s12011-014-0045-1
   Bonaventura P, 2015, AUTOIMMUN REV, V14, P277, DOI 10.1016/j.autrev.2014.11.008
   Bowden J, 2017, STAT MED, V36, P1783, DOI 10.1002/sim.7221
   Bowden J, 2015, INT J EPIDEMIOL, V44, P512, DOI 10.1093/ije/dyv080
   Chasapis CT, 2012, ARCH TOXICOL, V86, P521, DOI 10.1007/s00204-011-0775-1
   Choi WS, 2014, BIOL TRACE ELEM RES, V158, P323, DOI 10.1007/s12011-014-9946-2
   Czernichow S, 2009, AM J CLIN NUTR, V90, P329, DOI 10.3945/ajcn.2009.27635
   Davies NM, 2018, BMJ-BRIT MED J, V362, DOI 10.1136/bmj.k601
   Elsworth B, 2020, bioRxiv, DOI [10.1101/2020.08.10.244293, DOI 10.1101/2020.08.10.244293, 10.1101/2020.08.10.244293v1]
   Engin A, 2017, ADV EXP MED BIOL, V960, P1, DOI 10.1007/978-3-319-48382-5_1
   Evans DM, 2013, HUM MOL GENET, V22, P3998, DOI 10.1093/hmg/ddt239
   Fathi M, 2020, J TRACE ELEM MED BIO, V62, DOI 10.1016/j.jtemb.2020.126635
   Freitas EPS, 2017, NUTRIENTS, V9, DOI 10.3390/nu9020175
   Ghasemi A, 2014, ANN HUM BIOL, V41, P436, DOI 10.3109/03014460.2013.870228
   Gibson RS, 2016, FOOD NUTR BULL, V37, P443, DOI 10.1177/0379572116652252
   Girillo P, 2006, J AM SOC NEPHROL, V17, pS165, DOI 10.1681/ASN.2006080909
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Guo DJ, 2022, BIOL TRACE ELEM RES, V200, P2549, DOI 10.1007/s12011-021-02854-4
   Hashemipour M, 2009, HORM-INT J ENDOCRINO, V8, P279, DOI 10.14310/horm.2002.1244
   Hemani G, 2018, ELIFE, V7, DOI 10.7554/eLife.34408
   Hennigar SR, 2018, J NUTR, V148, P1341, DOI 10.1093/jn/nxy105
   Kim HN, 2018, J TRACE ELEM MED BIO, V48, P166, DOI 10.1016/j.jtemb.2018.03.022
   King JC, 2018, J NUTR, V148, P1399, DOI 10.1093/jn/nxy190
   Kloubert V, 2015, FOOD FUNCT, V6, P3195, DOI [10.1039/c5fo00630a, 10.1039/C5FO00630A]
   Kumssa DB, 2015, SCI REP-UK, V5, DOI 10.1038/srep10974
   Kunutsor SK, 2016, J HYPERTENS, V34, P1055, DOI 10.1097/HJH.0000000000000923
   Lear SA, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010015
   Matsui H, 2010, TOXICOLOGY, V276, P27, DOI 10.1016/j.tox.2010.06.011
   Miao X, 2013, FRONT MED-PRC, V7, P31, DOI 10.1007/s11684-013-0251-9
   Motamed Soudabe, 2013, N Am J Med Sci, V5, P377, DOI 10.4103/1947-2714.114171
   Namkoong S, 2013, ANN DERMATOL, V25, P67, DOI 10.5021/ad.2013.25.1.67
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Olechnowicz J, 2018, J PHYSIOL SCI, V68, P19, DOI 10.1007/s12576-017-0571-7
   Otto MCCD, 2011, J NUTR, V141, P1508, DOI 10.3945/jn.111.138115
   Plum LM, 2010, INT J ENV RES PUB HE, V7, P1342, DOI 10.3390/ijerph7041342
   Pushparani D S, 2014, J Indian Soc Periodontol, V18, P187, DOI 10.4103/0972-124X.131322
   Rocks T, 2022, MED J AUSTRALIA, V217, pS7, DOI 10.5694/mja2.51680
   Rotter I, 2015, INT J ENV RES PUB HE, V12, P3944, DOI 10.3390/ijerph120403944
   Ruz M, 2019, BIOL TRACE ELEM RES, V188, P177, DOI 10.1007/s12011-018-1611-8
   Sargazi M, 2013, J TRACE ELEM MED BIO, V27, P242, DOI 10.1016/j.jtemb.2012.12.004
   Seo JA, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0105990
   Soltani Z, 2013, CURR HYPERTENS REP, V15, P175, DOI 10.1007/s11906-013-0344-5
   Suarez-Ortegón MF, 2013, AM J HUM BIOL, V25, P550, DOI 10.1002/ajhb.22408
   Tubek S, 2006, BIOL TRACE ELEM RES, V114, P55, DOI 10.1385/BTER:114:1:55
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Voruganti VS, 2010, J TRACE ELEM MED BIO, V24, P271, DOI 10.1016/j.jtemb.2010.05.001
   Wang XH, 2019, AM J CLIN NUTR, V110, P76, DOI 10.1093/ajcn/nqz041
   Wang ZY, 2023, BRIT J NUTR, V129, P1929, DOI 10.1017/S0007114522002616
   Wessells KR, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0050568
   Xie DX, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2015-008637
   Yary T, 2017, NUTRITION, V37, P43, DOI 10.1016/j.nut.2016.09.004
   Yu YH, 2012, NUTR RES, V32, P71, DOI 10.1016/j.nutres.2011.12.004
   Zhang YY, 2018, NUTRIENTS, V10, DOI 10.3390/nu10050568
   Zhou HQ, 2019, INT J EPIDEMIOL, V48, P743, DOI 10.1093/ije/dyz121
NR 54
TC 2
Z9 2
U1 0
U2 11
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD JUL
PY 2024
VL 202
IS 7
BP 3051
EP 3061
DI 10.1007/s12011-023-03918-3
EA OCT 2023
PG 11
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA TU9Q5
UT WOS:001085337500001
PM 37857990
DA 2025-06-11
ER

PT J
AU Watson, MA
   Brar, H
   Gibbs, ET II
   Wong, HS
   Dighe, PA
   McKibben, B
   Riedmaier, S
   Siu, A
   Polakowski, JS
   Segreti, JA
   Liu, XQ
   Chung, SW
   Pliushchev, YM
   Gesmundo, N
   Wang, Z
   Vortherms, TA
   Brand, MD
AF Watson, Mark A.
   Brar, Harmanmeet
   Gibbs II, Edwin T.
   Wong, Hoi-Shan
   Dighe, Pratiksha A.
   McKibben, Bryan
   Riedmaier, Stephan
   Siu, Amy
   Polakowski, James S.
   Segreti, Jason A.
   Liu, Xiaoqin
   Chung, SeungWon
   Pliushchev, Y. Marina
   Gesmundo, Nathan
   Wang, Zhi
   Vortherms, Timothy A.
   Brand, Martin D.
TI Suppression of superoxide/hydrogen peroxide production at mitochondrial
   site IQ decreases fat accumulation, improves glucose tolerance and
   normalizes fasting insulin concentration in mice fed a high-fat diet
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Mitochondria; S1QEL; Complex I; Glucose tolerance; Insulin; Reactive
   oxygen species
ID HYDROGEN-PEROXIDE; METABOLIC SYNDROME; OXIDATIVE STRESS; LACTIC
   ACIDEMIA; RESISTANCE; EMISSION; FEATURES; H2O2; VIVO
AB We developed S1QEL1.719, a novel bioavailable S1QEL (suppressor of site IQ electron leak). S1QEL1.719 prevented superoxide/hydrogen peroxide production at site IQ of mitochondrial complex I in vitro. The free concentration giving half-maximal suppression (IC50) was 52 nM. Even at 50-fold higher concentrations S1QEL1.719 did not inhibit superoxide/hydrogen peroxide production from other sites. The IC50 for inhibition of complex I electron flow was 500-fold higher than the IC50 for suppression of superoxide/hydrogen peroxide production from site IQ. S1QEL1.719 was used to test the metabolic effects of suppressing superoxide/hydrogen peroxide production from site IQ in vivo. C57BL/6J male mice fed a high-fat chow for one, two or eight weeks had increased body fat, decreased glucose tolerance, and increased fasting insulin concentrations, classic symptoms of metabolic syndrome. Daily prophylactic or therapeutic oral treatment of high-fat-fed animals with S1QEL1.719 decreased fat accumulation, strongly protected against decreased glucose tolerance and prevented or reversed the increase in fasting insulin level. Free exposures in plasma and liver at Cmax were 1-4 fold the IC50 for suppression of superoxide/hydrogen peroxide production at site IQ and substantially below levels that inhibit electron flow through complex I. These results show that the production of superoxide/hydrogen peroxide from mitochondrial site IQ in vivo is necessary for the induction and maintenance of glucose intolerance caused by a high-fat diet in mice. They raise the possibility that oral administration of S1QELs may be beneficial in metabolic syndrome.
C1 [Watson, Mark A.; Brar, Harmanmeet; Gibbs II, Edwin T.; Wong, Hoi-Shan; Dighe, Pratiksha A.; Brand, Martin D.] Buck Inst Res Aging, 8001 Redwood Blvd, Novato, CA 94945 USA.
   [McKibben, Bryan; Riedmaier, Stephan; Siu, Amy; Polakowski, James S.; Segreti, Jason A.; Liu, Xiaoqin; Chung, SeungWon; Pliushchev, Y. Marina; Gesmundo, Nathan; Wang, Zhi; Vortherms, Timothy A.] AbbVie Inc, 1 North Waukegan Rd, N Chicago, IL 60064 USA.
C3 Buck Institute for Research on Aging; AbbVie
RP Brand, MD (corresponding author), Buck Inst Res Aging, 8001 Redwood Blvd, Novato, CA 94945 USA.
EM mwatson@buckinstitute.org; harrmanb@gmail.com; eddygibbs007@yahoo.com;
   helenwonghs@gmail.com; pashadighe@gmail.com; bryan.mckibben@abbvie.com;
   stephan.riedmaier@bms.com; amy.y.siu@gmail.com;
   james.polakoski@abbvie.com; jason.segreti@abbvie.com;
   xiaoquin.liu@abbvie.com; seungwon.chung@abbvie.com;
   marina.pliushchev@abbvie.com; nathan.gesmundo@abbvie.com;
   zhi.wang@abbvie.com; timothy.vortherms@abbvie.com;
   mbrand@buckinstitute.org
RI Brand, Martin/A-9423-2012; Liu, Xiaoqin/AAB-7509-2019
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Anderson EJ, 2009, J CLIN INVEST, V119, P573, DOI 10.1172/JCI37048
   Andrikopoulos S, 2008, AM J PHYSIOL-ENDOC M, V295, pE1323, DOI 10.1152/ajpendo.90617.2008
   Benjamin EJ, 2019, CIRCULATION, V139, pE56, DOI [10.1161/CIR.0000000000000659, 10.1161/CIR.0000000000000746]
   Bhatti JS, 2017, BBA-MOL BASIS DIS, V1863, P1066, DOI 10.1016/j.bbadis.2016.11.010
   Bongard RD, 2013, FREE RADICAL BIO MED, V65, P1455, DOI 10.1016/j.freeradbiomed.2013.07.040
   Brand M.D., CELL METABOL
   Brand MD, 2020, CRIT REV BIOCHEM MOL, V55, P592, DOI 10.1080/10409238.2020.1828258
   Brand MD, 2016, FREE RADICAL BIO MED, V100, P14, DOI 10.1016/j.freeradbiomed.2016.04.001
   Chen LJ, 2008, AGING CELL, V7, P866, DOI 10.1111/j.1474-9726.2008.00432.x
   Fang JQ, 2022, FREE RADICAL BIO MED, V188, P92, DOI 10.1016/j.freeradbiomed.2022.06.225
   Fang JQ, 2020, REDOX BIOL, V37, DOI 10.1016/j.redox.2020.101722
   Feillet-Coudray C, 2014, FREE RADICAL RES, V48, P1232, DOI 10.3109/10715762.2014.945079
   Forrester SJ, 2018, CIRC RES, V122, P877, DOI 10.1161/CIRCRESAHA.117.311401
   Gabriely I, 2002, DIABETES, V51, P2951, DOI 10.2337/diabetes.51.10.2951
   Gibbs ET II, 2023, BIOCHEM J, V480, P363, DOI 10.1042/BCJ20220611
   Goncalve RLS, 2020, REDOX BIOL, V28, DOI 10.1016/j.redox.2019.101341
   Goncalves RLS, 2015, J BIOL CHEM, V290, P209, DOI 10.1074/jbc.M114.619072
   Goodpaster BH, 1999, DIABETES, V48, P839, DOI 10.2337/diabetes.48.4.839
   Gorman GS, 2016, NAT REV DIS PRIMERS, V2, P1, DOI 10.1038/nrdp.2016.80
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Iversen NK, 2012, RESP PHYSIOL NEUROBI, V180, P252, DOI 10.1016/j.resp.2011.11.015
   James AM, 2012, TRENDS ENDOCRIN MET, V23, P429, DOI 10.1016/j.tem.2012.06.008
   Jeong EM, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.115.003046
   Karlsson M, 2016, MITOCHONDRION, V31, P56, DOI 10.1016/j.mito.2016.10.003
   Lee HY, 2017, DIABETES, V66, P2072, DOI 10.2337/db16-1334
   Liu YH, 2013, BIOCHEM BIOPH RES CO, V438, P78, DOI 10.1016/j.bbrc.2013.07.029
   Mao GW, 2010, J NUTR, V140, P1425, DOI 10.3945/jn.110.121715
   Mc Namara K, 2019, INTEGR PHARM RES PRA, V8, P1, DOI 10.2147/IPRP.S133088
   McGuinness OP, 2009, AM J PHYSIOL-ENDOC M, V297, pE849, DOI 10.1152/ajpendo.90996.2008
   Mercer JR, 2012, FREE RADICAL BIO MED, V52, P841, DOI 10.1016/j.freeradbiomed.2011.11.026
   Mookerjee SA, 2015, BBA-BIOENERGETICS, V1847, P171, DOI 10.1016/j.bbabio.2014.10.005
   Ogasawara E, 2010, HUM MOL GENET, V19, P3179, DOI 10.1093/hmg/ddq228
   Orr DL, 2015, NAT CHEM BIOL, V11, P834, DOI [10.1038/nchembio.1910, 10.1038/NCHEMBIO.1910]
   Paglialunga S, 2015, DIABETOLOGIA, V58, P1071, DOI 10.1007/s00125-015-3531-x
   Robinson BH, 2006, MOL GENET METAB, V89, P3, DOI 10.1016/j.ymgme.2006.05.015
   Rodgers JL, 2019, J CARDIOVASC DEV DIS, V6, DOI 10.3390/jcdd6020019
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Watson MA, 2021, AGING CELL, V20, DOI 10.1111/acel.13476
   Watson MA, 2019, BIOCHEM SOC T, V47, P1461, DOI 10.1042/BST20190305
   Williams LM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0106159
   Wong H.-S., FREE RADIC BIOL
   Wong HS, 2019, FREE RADICAL BIO MED, V130, P140, DOI 10.1016/j.freeradbiomed.2018.10.448
   Wong HS, 2017, J BIOL CHEM, V292, P16804, DOI 10.1074/jbc.R117.789271
   Yazdanyar A, 2009, CLIN GERIATR MED, V25, P563, DOI 10.1016/j.cger.2009.07.007
NR 45
TC 6
Z9 6
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD AUG 1
PY 2023
VL 204
BP 276
EP 286
DI 10.1016/j.freeradbiomed.2023.05.022
EA MAY 2023
PG 11
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA K5FG9
UT WOS:001016690200001
PM 37217089
OA hybrid
DA 2025-06-11
ER

PT J
AU Ruz, M
   Carrasco, F
   Rojas, P
   Basfi-fer, K
   Hernández, MC
   Pérez, A
AF Ruz, Manuel
   Carrasco, Fernando
   Rojas, Pamela
   Basfi-fer, Karen
   Catalina Hernandez, Maria
   Perez, Alvaro
TI Nutritional Effects of Zinc on Metabolic Syndrome and Type 2 Diabetes:
   Mechanisms and Main Findings in Human Studies
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Zinc; Metabolic syndrome; Diabetes
ID POLYCYSTIC-OVARY-SYNDROME; INSULIN-RESISTANCE; GLYCEMIC CONTROL;
   DOUBLE-BLIND; SERUM ZINC; ALLIXIN COMPLEXES; OXIDATIVE STRESS;
   TNF-ALPHA; SUPPLEMENTATION; RISK
AB Zinc (Zn) plays crucial roles in mammalian metabolism. There is increasing interest about the potential beneficial effects of Zn on the prevention or treatment of non-communicable diseases. This review critically analyzes the information related to the role of Zn on the metabolic syndrome (MetS) as well as type 2 diabetes (T2D), and summarizes the biological basis of these potential effects of Zn. There are several mechanisms by which Zn may help to prevent the development or progression of MetS and T2D, respectively. Zn is involved in both insulin secretion and action in peripheral tissues. Specifically, Zn has insulin-mimetic properties that increase the activity of the insulin signaling pathway. Zn modulates long-chain polyunsaturated fatty acids levels through its action on the absorption of essential fatty acids in the intestine and its subsequent desaturation. Zn is also involved in both the assembly of chylomicrons and lipoproteins as well as their clearance, and thus, plays a role in lipolysis regulation. Finally, Zn has been found to play a role in redox metabolism, and in turn, on blood pressure. The evidence related to the association between Zn status and occurrence of MetS is inconsistent. Although there are several studies reporting an inverse relationship between Zn status or dietary Zn intake and MetS prevalence, others found a direct relationship between Zn status and MetS prevalence. Intervention studies also provide confusing information about this issue, making it hard to reach firm conclusions. Zn as part of the treatment for patients with T2D has been shown to have positive responses in terms of glucose control outcomes, but only among those with Zn deficiency.
C1 [Ruz, Manuel; Carrasco, Fernando; Rojas, Pamela; Basfi-fer, Karen; Catalina Hernandez, Maria; Perez, Alvaro] Univ Chile, Fac Med, Dept Nutr, Santiago 1027, Chile.
C3 Universidad de Chile
RP Ruz, M (corresponding author), Univ Chile, Fac Med, Dept Nutr, Santiago 1027, Chile.
EM mruz@med.uchile.cl
RI Rojas, Pamela/N-5500-2018; Hernández-Rodas, María/ABG-5275-2021; Perez,
   Alvaro/N-8244-2017
OI Perez, Alvaro/0000-0001-8812-3301; Hernandez Rodas, Maria
   Catalina/0000-0001-9516-4056; Rojas, Pamela/0000-0001-6629-357X;
   Basfi-fer, Karen/0000-0002-9824-0162; Carrasco,
   Fernando/0000-0003-1103-3791
FU National Fund for Development of Science and Technology (FONDECYT)
   [1160792]; National Commission for Research in Science and Technology
   (CONICYT)-Advanced Human Capital Formation Program, National Doctoral
   Fellowship 2016 [21160453]
FX This research was funded by the National Fund for Development of Science
   and Technology (FONDECYT), research project 1160792 and by the National
   Commission for Research in Science and Technology (CONICYT)-Advanced
   Human Capital Formation Program, National Doctoral Fellowship 2016, No.
   21160453 (to MCH).
CR Afkhami-Ardekani M., 2008, Pakistan Journal of Nutrition, V7, P550, DOI 10.3923/pjn.2008.550.553
   Ahn BI, 2014, BIOL TRACE ELEM RES, V160, P169, DOI 10.1007/s12011-014-0045-1
   Al-Daghri NM, 2013, NUTRIENTS, V5, P4587, DOI 10.3390/nu5114587
   Al-Maroof RA, 2006, SAUDI MED J, V27, P344
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Alderton WK, 2001, BIOCHEM J, V357, P593, DOI 10.1042/0264-6021:3570593
   American Diabetes Association, 2018, Diabetes Care, V41, pS13, DOI 10.2337/dc18-S002
   [Anonymous], ENCY FOOD SCI NUTR
   [Anonymous], 2001, DIET REF INT VIT A V
   Arnaud J, 2012, NUTR METAB CARDIOVAS, V22, P517, DOI 10.1016/j.numecd.2010.09.005
   Bao B, 2010, AM J CLIN NUTR, V91, P1634, DOI 10.3945/ajcn.2009.28836
   Bozym RA, 2010, EXP BIOL MED, V235, P741, DOI 10.1258/ebm.2010.009258
   Cameron AR, 2010, METALLOMICS, V2, P195, DOI 10.1039/b914984h
   Chabosseau P, 2016, ARCH BIOCHEM BIOPHYS, V611, P79, DOI 10.1016/j.abb.2016.05.022
   Chimienti F, 2006, J CELL SCI, V119, P4199, DOI 10.1242/jcs.03164
   Choi WS, 2014, BIOL TRACE ELEM RES, V158, P323, DOI 10.1007/s12011-014-9946-2
   CLEJAN S, 1982, LIPIDS, V17, P129, DOI 10.1007/BF02535092
   COFFMAN FD, 1988, BIOCHEMISTRY-US, V27, P6179, DOI 10.1021/bi00416a053
   COULSTON L, 1980, DIABETES, V29, P665, DOI 10.2337/diabetes.29.8.665
   Cuevas A, 2011, CURR OPIN ENDOCRINOL, V18, P134, DOI 10.1097/MED.0b013e3283449167
   Czernichow S, 2009, AM J CLIN NUTR, V90, P329, DOI 10.3945/ajcn.2009.27635
   DiSilvestro RA, 2015, BIOL TRACE ELEM RES, V168, P11, DOI 10.1007/s12011-015-0334-3
   Drake I, 2017, GENES NUTR, V12, DOI 10.1186/s12263-017-0586-y
   Echeverría F, 2016, PROSTAG LEUKOTR ESS, V114, P28, DOI 10.1016/j.plefa.2016.10.001
   El Dib R, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005525.pub3
   Farvid MS, 2011, DIABETES RES CLIN PR, V93, P86, DOI 10.1016/j.diabres.2011.03.016
   Farvid MS, 2005, DIABETES CARE, V28, P2458, DOI 10.2337/diacare.28.10.2458
   Ford ES, 2008, DIABETES CARE, V31, P1898, DOI 10.2337/dc08-0423
   Foroozanfard F, 2015, EXP CLIN ENDOCR DIAB, V123, P215, DOI 10.1055/s-0035-1548790
   Foster M, 2014, J TRACE ELEM MED BIO, V28, P448, DOI 10.1016/j.jtemb.2014.07.012
   Foster M, 2010, ANTIOXID REDOX SIGN, V13, P1549, DOI 10.1089/ars.2010.3111
   Freitas EPS, 2017, NUTRIENTS, V9, DOI 10.3390/nu9020175
   Fruchart J C, 2001, Curr Atheroscler Rep, V3, P83, DOI 10.1007/s11883-001-0015-x
   Fukunaka A, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19020476
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Gammoh NZ, 2017, NUTRIENTS, V9, DOI 10.3390/nu9060624
   Ghasemi A, 2014, ANN HUM BIOL, V41, P436, DOI 10.3109/03014460.2013.870228
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Gunasekara P, 2011, DIABET METAB SYND OB, V4, P53, DOI 10.2147/DMSO.S16691
   Gupta R, 1998, J Assoc Physicians India, V46, P939
   Haase H, 2005, BIOMETALS, V18, P333, DOI 10.1007/s10534-005-3707-9
   Hashemipour M, 2009, HORM-INT J ENDOCRINO, V8, P279, DOI 10.14310/horm.2002.1244
   Hayee M A, 2005, Bangladesh Med Res Counc Bull, V31, P62
   HEGAZI SM, 1992, J CLIN BIOCHEM NUTR, V12, P209
   Heidarzadeh Z, 2017, BIOL TRACE ELEM RES, V175, P271, DOI 10.1007/s12011-016-0788-y
   Hermann Matthias, 2006, J Clin Hypertens (Greenwich), V8, P17, DOI 10.1111/j.1524-6175.2006.06032.x
   Hiromura M, 2008, PURE APPL CHEM, V80, P2727, DOI 10.1351/pac200880122727
   HUANG YS, 1982, ATHEROSCLEROSIS, V41, P193, DOI 10.1016/0021-9150(82)90185-X
   Hussain SA, 2006, SAUDI MED J, V27, P1483
   Islam MR, 2016, DIABETES RES CLIN PR, V115, P39, DOI 10.1016/j.diabres.2016.03.010
   Jamilian M, 2016, BIOL TRACE ELEM RES, V170, P271, DOI 10.1007/s12011-015-0480-7
   Jansen J, 2009, J NUTR BIOCHEM, V20, P399, DOI 10.1016/j.jnutbio.2009.01.009
   Kajanachumpol S, 1995, J Med Assoc Thai, V78, P344
   Kassoff A, 1999, CONTROL CLIN TRIALS, V20, P573
   Kelishadi R, 2010, METAB SYNDR RELAT D, V8, P505, DOI 10.1089/met.2010.0020
   Kelleher SL, 2011, ADV NUTR, V2, P101, DOI 10.3945/an.110.000232
   King JC, 2011, AM J CLIN NUTR, V94, p679S, DOI 10.3945/ajcn.110.005744
   Kroker AJ, 2015, PPAR RES, V2015, DOI 10.1155/2015/816856
   Livingstone C, 2015, NUTR CLIN PRACT, V30, P371, DOI 10.1177/0884533615570376
   Lobene AJ, 2017, J NUTR, V147, P1296, DOI 10.3945/jn.117.248013
   Lowe NM, 2009, AM J CLIN NUTR, V89, p2040S, DOI 10.3945/ajcn.2009.27230G
   Maret W, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18112285
   Maruthur NM, 2015, DIABETOLOGIA, V58, P295, DOI 10.1007/s00125-014-3419-1
   Meigs JB, 2006, J CLIN ENDOCR METAB, V91, P2906, DOI 10.1210/jc.2006-0594
   Miao X, 2013, FRONT MED-PRC, V7, P31, DOI 10.1007/s11684-013-0251-9
   Ministerio de Salud, GOBIERNO CHILE ENCUE
   Mispireta ML, 2017, J DEV ORIG HLTH DIS, V8, P56, DOI 10.1017/S2040174416000568
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Nakayama A, 2008, J BIOL INORG CHEM, V13, P675, DOI 10.1007/s00775-008-0352-0
   Noh SK, 2001, EXP BIOL MED, V226, P342, DOI 10.1177/153537020122600412
   Obeid O, 2008, BIOL TRACE ELEM RES, V123, P58, DOI 10.1007/s12011-008-8112-0
   Oh Hyun-Mee, 2008, Nutr Res Pract, V2, P283, DOI 10.4162/nrp.2008.2.4.283
   Oteiza PI, 2012, FREE RADICAL BIO MED, V53, P1748, DOI 10.1016/j.freeradbiomed.2012.08.568
   Otto MCD, 2012, J NUTR, V142, P526, DOI 10.3945/jn.111.149781
   Parham Mahmoud, 2008, Rev Diabet Stud, V5, P102, DOI 10.1900/RDS.2008.5.102
   Partida-Hernández G, 2006, BIOMED PHARMACOTHER, V60, P161, DOI 10.1016/j.biopha.2006.02.004
   Ramracheya R, 2010, DIABETES, V59, P2198, DOI 10.2337/db09-1505
   RUZ M, 1991, AM J CLIN NUTR, V53, P1295, DOI 10.1093/ajcn/53.5.1295
   Ruz M, 2016, CURR DIABETES REP, V16, DOI 10.1007/s11892-016-0803-x
   Seet RCS, 2011, ATHEROSCLEROSIS, V219, P231, DOI 10.1016/j.atherosclerosis.2011.07.097
   Seo JA, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0105990
   Sladek R, 2007, NATURE, V445, P881, DOI 10.1038/nature05616
   Song YQ, 2011, DIABETES CARE, V34, P108, DOI 10.2337/dc10-1260
   Stewart CP, 2009, J NUTR, V139, P1575, DOI 10.3945/jn.109.106666
   Suarez-Ortegón MF, 2013, AM J HUM BIOL, V25, P550, DOI 10.1002/ajhb.22408
   Sun Q, 2009, DIABETES CARE, V32, P629, DOI 10.2337/dc08-1913
   Tamaki M, 2013, J CLIN INVEST, V123, P4513, DOI 10.1172/JCI68807
   Troche C, 2016, AM J PHYSIOL-ENDOC M, V310, pE258, DOI 10.1152/ajpendo.00421.2015
   Umrani RD, 2014, NANOMEDICINE-UK, V9, P89, DOI 10.2217/nnm.12.205
   Vardatsikos G, 2013, J INORG BIOCHEM, V120, P8, DOI 10.1016/j.jinorgbio.2012.11.006
   Vashum KP, 2013, BMC ENDOCR DISORD, V13, DOI 10.1186/1472-6823-13-40
   von Bülow V, 2007, J IMMUNOL, V179, P4180, DOI 10.4049/jimmunol.179.6.4180
   von Bülow V, 2005, J IMMUNOL, V175, P4697, DOI 10.4049/jimmunol.175.7.4697
   Wei SJ, 2013, CELL MOL LIFE SCI, V70, P4569, DOI 10.1007/s00018-013-1395-0
   Wijesekara N, 2010, DIABETOLOGIA, V53, P1656, DOI 10.1007/s00125-010-1733-9
   Yary T, 2017, NUTRITION, V37, P43, DOI 10.1016/j.nut.2016.09.004
   Yu YH, 2012, NUTR RES, V32, P71, DOI 10.1016/j.nutres.2011.12.004
   Zhou HR, 2007, DIABETES, V56, P1107, DOI 10.2337/db06-1454
   Zou MH, 2002, J CLIN INVEST, V109, P817, DOI 10.1172/JCI200214442
NR 100
TC 59
Z9 68
U1 2
U2 35
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD MAR
PY 2019
VL 188
IS 1
BP 177
EP 188
DI 10.1007/s12011-018-1611-8
PG 12
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA HL3JN
UT WOS:000458610600016
PM 30600497
DA 2025-06-11
ER

PT J
AU Moreno-Fernández, S
   Garcés-Rimón, M
   Vera, G
   Astier, J
   Landrier, JF
   Miguel, M
AF Moreno-Fernandez, Silvia
   Garces-Rimon, Marta
   Vera, Gema
   Astier, Julien
   Landrier, Jean Francois
   Miguel, Marta
TI High Fat/High Glucose Diet Induces Metabolic Syndrome in an Experimental
   Rat Model
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; obesity; diet induced obesity; rat model; high
   glucose; high fructose
ID INDUCED INSULIN-RESISTANCE; HIGH-FRUCTOSE; EXPRESSION; MITOCHONDRIA;
   BIOCHEMISTRY; DYSFUNCTION; OVERWEIGHT; OBESITY
AB Metabolic syndrome (MetS) is defined as a constellation of many metabolic disorders such as hypertension, impaired glucose tolerance, dyslipidemia and obesity, being this last disorder a key factor in the etiology of the syndrome. The widespread of MetS in actual society, mainly in developed countries, is becoming an important health problem and is increasing the need to develop new treatments against this pathology is increasing fast. The main objective of the present study was to evaluate the MetS-associated alterations developed in a new glucose diet-induced-obesity (DIO) rodent model. These alterations were also compared to those alterations developed in a fructose-DIO rodent model. Wistar rats were divided into four groups: Control (C), High-fat (HF), High-fat/high-fructose (HFF) and High-fat/high-glucose (HFG). The animals were fed ad libitum for 20 weeks. At the end of the study, HFG animals showed lower expression of energy expenditure genes when compared to the other DIO groups. Oxidative stress biomarkers such as MDA and mitochondrial RT-qPCR analyses showed an increase of oxidative damage together with mitochondrial dysfunction in HFG group. This group also showed increased insulin and glucose plasma levels, though HFF animals showed the greatest increase on these parameters. All DIO groups showed increased plasma levels of triglycerides. Altogether, our results indicated a better impact of glucose than fructose, when combined with a high-fat diet, to induce most of the alterations associated with MetS in rats. In addition, our research facilitates a new animal model to evaluate future treatments for MetS.
C1 [Moreno-Fernandez, Silvia; Miguel, Marta] UAM, CSIC, Bioact Anal Alimentos, Inst Invest Ciencias Alimentac,CIAL, Madrid 28049, Spain.
   [Moreno-Fernandez, Silvia; Vera, Gema; Miguel, Marta] CSIC, Inst Invest Ciencias Alimentac CIAL, Unidad Asociada IDi, E-28049 Madrid, Spain.
   [Garces-Rimon, Marta] Univ Francisco Vitoria, Inst Invest Biosanitarias, Grp Invest Biotecnol Alimentaria, Madrid 28233, Spain.
   [Vera, Gema] Univ Rey Juan Carlos, Fac Ciencias Salud, Dept Ciencias Basicas, Madrid 28922, Spain.
   [Astier, Julien; Landrier, Jean Francois] Aix Marseille Univ, INSERM, INRA, NORT, F-13385 Marseille, France.
C3 Autonomous University of Madrid; Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC-UAM - Instituto de Investigacion en Ciencias de
   la Alimentacion (CIAL); Consejo Superior de Investigaciones Cientificas
   (CSIC); CSIC-UAM - Instituto de Investigacion en Ciencias de la
   Alimentacion (CIAL); Universidad Francisco de Vitoria; Universidad Rey
   Juan Carlos; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Aix-Marseille Universite; INRAE
RP Miguel, M (corresponding author), UAM, CSIC, Bioact Anal Alimentos, Inst Invest Ciencias Alimentac,CIAL, Madrid 28049, Spain.; Miguel, M (corresponding author), CSIC, Inst Invest Ciencias Alimentac CIAL, Unidad Asociada IDi, E-28049 Madrid, Spain.
EM silvia.moreno@csic.es; marta.garces@ufv.es; gema.vera@urjc.es;
   julien.astier@univ-amu.fr; jean-francois.landrier@univ-amu.fr;
   marta.miguel@csic.es
RI Vera, Gema/AAB-1731-2019; Garces-Rimon, Marta/AAD-3050-2021; MIGUEL
   CASTRO, MARTA/F-6112-2011; Landrier, Jean-Francois/AAH-2757-2019
OI Moreno-Fernandez, Silvia/0000-0002-9316-6477; Garces-Rimon,
   Marta/0000-0002-3888-4150; MIGUEL CASTRO, MARTA/0000-0002-5525-1056;
   Landrier, Jean-Francois/0000-0002-8690-8014; Vera Pasamontes,
   Gema/0000-0002-1838-0975
FU Spanish Ministry of Economy, Industry and Competitiveness (MINECO)
   [AGL2012-32387, AGL2017-89213, CSIC-INTRAMURAL 201570I028,
   BES-2013-065684, EEBB-I-16-11349]
FX This work was supported by the Spanish Ministry of Economy, Industry and
   Competitiveness (MINECO) (under the projects AGL2012-32387,
   AGL2017-89213 and CSIC-INTRAMURAL 201570I028 and under the grant numbers
   BES-2013-065684 and EEBB-I-16-11349).
CR Aslam M, 2017, ENDOCRINE, V58, P59, DOI 10.1007/s12020-017-1403-5
   Assifi M.M., 2012, NUTR DIET CANC
   Aydin S, 2014, NUTRITION, V30, P1, DOI 10.1016/j.nut.2013.05.013
   Bhatti JS, 2017, BBA-MOL BASIS DIS, V1863, P1066, DOI 10.1016/j.bbadis.2016.11.010
   Bonomini F, 2015, AGING DIS, V6, P109, DOI 10.14336/AD.2014.0305
   Boulinguiez A, 2017, BBA-MOL CELL BIOL L, V1862, P901, DOI 10.1016/j.bbalip.2017.05.011
   Crescenzo R, 2015, EUR J NUTR, V54, P183, DOI 10.1007/s00394-014-0699-7
   Delvarianzadeh M, 2017, DIABETES METAB SYND, V11, pS907, DOI 10.1016/j.dsx.2017.07.014
   Fenni S, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201601083
   Garcés-Rimón M, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0151193
   García-Ruiz E, 2015, INT J OBESITY, V39, P1619, DOI 10.1038/ijo.2015.112
   Grundy SM, 2016, J INVEST MED, V64, P1082, DOI 10.1136/jim-2016-000155
   Hafizi Abu Bakar M., 2015, DIABETES-METAB RES, V31, P453, DOI [10.1002/dmrr.260125139820, DOI 10.1002/DMRR.2601]
   Hull P., 2010, Glucose syrups: technology and applications
   Johnston RD, 2013, GASTROENTEROLOGY, V145, P1016, DOI 10.1053/j.gastro.2013.07.012
   Kamencic H, 2000, ANAL BIOCHEM, V286, P35, DOI 10.1006/abio.2000.4765
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   Lupachyk S, 2012, FREE RADICAL BIO MED, V52, P1255, DOI 10.1016/j.freeradbiomed.2012.01.029
   Maithilikarpagaselvi N, 2016, CHEM-BIOL INTERACT, V244, P187, DOI 10.1016/j.cbi.2015.12.012
   Manso MA, 2008, FOOD CHEM, V109, P361, DOI 10.1016/j.foodchem.2007.12.049
   Marcotorchino J, 2014, J NUTR BIOCHEM, V25, P1077, DOI 10.1016/j.jnutbio.2014.05.010
   Merone L, 2017, DIABETES RES CLIN PR, V127, P238, DOI 10.1016/j.diabres.2017.02.019
   Myers KP, 2017, APPETITE, V112, P196, DOI 10.1016/j.appet.2017.01.013
   Panchal SK, 2011, J CARDIOVASC PHARM, V57, P51, DOI [10.1097/FJC.0b013e3181feb90a, 10.1097/FJC.0b013e31821b1379]
   Panchal SK, 2011, J BIOMED BIOTECHNOL, DOI 10.1155/2011/351982
   Pereira RM, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040405
   Popkin BM, 2015, CURR DIABETES REP, V15, DOI 10.1007/s11892-015-0631-4
   Putakala M, 2017, APPL BIOCHEM BIOTECH, V183, P744, DOI 10.1007/s12010-017-2461-0
   Rakhshandehroo M, 2010, PPAR RES, V2010, DOI 10.1155/2010/612089
   Rippe JM, 2016, NUTRIENTS, V8, DOI 10.3390/nu8110697
   Sah SP, 2016, PHARMACOL REP, V68, P1165, DOI 10.1016/j.pharep.2016.07.010
   Schrover IM, 2016, HORM METAB RES, V48, P213, DOI 10.1055/s-0042-103243
   Seo DC, 2017, PREV MED, V97, P100, DOI 10.1016/j.ypmed.2017.01.012
   Shawky NM, 2014, EUR J PHARMACOL, V740, P353, DOI 10.1016/j.ejphar.2014.07.021
   Singh P, 2016, INT J OBESITY, V40, P266, DOI 10.1038/ijo.2015.181
   Tourniaire F, 2015, J LIPID RES, V56, P1100, DOI 10.1194/jlr.M053652
   Trayhurn P, 2017, BIOCHIMIE, V134, P62, DOI 10.1016/j.biochi.2016.09.007
   Tsuchida A, 2004, J BIOL CHEM, V279, P30817, DOI 10.1074/jbc.M402367200
   Vasques ACJ, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0125365
   Vera G, 2007, LIFE SCI, V81, P468, DOI 10.1016/j.lfs.2007.06.012
NR 40
TC 156
Z9 164
U1 2
U2 24
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2018
VL 10
IS 10
AR 1502
DI 10.3390/nu10101502
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GY7UM
UT WOS:000448821300168
PM 30322196
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Park, B
   Lee, YJ
AF Park, Byoungjin
   Lee, Yong-Jae
TI Metabolic syndrome and its components as risk factors for prolonged
   corrected QT interval in apparently healthy Korean men and women
SO JOURNAL OF CLINICAL LIPIDOLOGY
LA English
DT Article
DE Metabolic syndrome; Insulin resistance; QTc interval; Arrhythmia
ID MYOCARDIAL-INFARCTION; CARDIOVASCULAR MORTALITY; DIABETES-MELLITUS;
   OXIDATIVE STRESS; ASSOCIATION; DISPERSION; INSULIN; DYSFUNCTION;
   POPULATION; DYNAMICS
AB BACKGROUND: Metabolic syndrome (MetS) is clinically important because of its association with increased risk of sudden cardiac death, as well as cardiovascular disease-related mortality. Data between MetS and prolonged corrected QT (QTc) intervals, a useful predictor of sudden cardiac death, are limited in apparently healthy adults.
   OBJECTIVE: This study determined the association between MetS and QTc interval in apparently healthy Korean men and women.
   METHODS: We examined the association between MetS and QTc interval in 2157 Korean adults (1317 men and 840 women) in a health examination program but excluded participants with a history of ischemic heart disease, stroke, cardiac arrhythmia, cancer, thyroid, respiratory, renal, hepatobiliary, or rheumatologic disease. The QTc interval was calculated using Bazett's formula (QTc = QT/root RR). Multivariate-adjusted mean QTc values by the number of MetS components were calculated after sex stratification and compared using analysis of covariance test.
   RESULTS: The overall prevalence of MetS was 30.5% in men and 19.8% in women. The QTc interval positively correlated with age, body mass index, blood pressure, fasting plasma glucose, triglycerides, and potassium level in both men and women and negatively correlated with calcium and potassium levels and smoking status in men. The multivariate-adjusted mean QTc value increased proportionally with increasing number of MetS components (P values < 0.001 for both men and women).
   CONCLUSION: We confirmed the arrhythmogenic potential of MetS in apparently healthy Korean men and women. These findings suggest that careful monitoring of electrocardiography is necessary to evaluate possible arrhythmic risk in individuals with MetS. (C) 2018 National Lipid Association. All rights reserved.
C1 [Park, Byoungjin; Lee, Yong-Jae] Yonsei Univ, Coll Med, Dept Family Med, Seoul, South Korea.
   [Park, Byoungjin] Yongin Severance Hosp, Dept Family Med, Yongin, Gyeonggi Do, South Korea.
   [Lee, Yong-Jae] Univ Nevada, Sch Community Hlth Sci, Dept Healthcare Adm & Policy, Las Vegas, NV 89154 USA.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University Health System; Nevada System of Higher Education
   (NSHE); University of Nevada Las Vegas
RP Lee, YJ (corresponding author), Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Family Med, 211 Eonju Ro, Seoul 06273, South Korea.
EM ukyjhome@yuhs.ac
RI Lee, Yong Jae/GLR-4153-2022; Park, Byoungjin/AAV-1810-2020
OI Park, Byoungjin/0000-0003-1733-5301; Lee, Yong-Jae/0000-0002-6697-476X
CR AHNVE S, 1985, AM HEART J, V109, P568, DOI 10.1016/0002-8703(85)90564-2
   AHNVE S, 1985, EUR HEART J, V6, P85, DOI 10.1093/eurheartj/6.suppl_D.85
   Alonso JL, 2005, ANN NONINVAS ELECTRO, V10, P121, DOI 10.1111/j.1542-474X.2005.05583.x
   Arslan E, 2010, POL ARCH MED WEWN, V120, P209, DOI 10.20452/pamw.927
   Chauhan VS, 2002, AM HEART J, V144, P858, DOI 10.1067/mhj.2002.125619
   DEKKER JM, 1994, CIRCULATION, V90, P779, DOI 10.1161/01.CIR.90.2.779
   Dekker JM, 1996, DIABETES, V45, P376, DOI 10.2337/diabetes.45.3.376
   Du XL, 2006, J CLIN INVEST, V116, P1071, DOI 10.1172/JCI23354
   Einhorn Daniel, 2003, Endocr Pract, V9, P237
   Empana JP, 2007, EUR HEART J, V28, P1149, DOI 10.1093/eurheartj/ehm063
   Faramawi MF, 2008, EUR J EPIDEMIOL, V23, P459, DOI 10.1007/s10654-008-9252-4
   Giacco F, 2010, CIRC RES, V107, P1058, DOI 10.1161/CIRCRESAHA.110.223545
   GOLDBERG RJ, 1991, AM J CARDIOL, V67, P55, DOI 10.1016/0002-9149(91)90099-7
   Isik T, 2012, ACTA CARDIOL, V67, P195, DOI 10.2143/AC.67.2.2154210
   Kacheva S, 2017, DIABETES RES CLIN PR, V123, P165, DOI 10.1016/j.diabres.2016.11.021
   Kim E, 2006, EUR J EPIDEMIOL, V21, P653, DOI 10.1007/s10654-006-9034-9
   LEPESCHKIN E, 1952, CIRCULATION, V6, P378, DOI 10.1161/01.CIR.6.3.378
   Li Weiju, 2009, Clin Cardiol, V32, pE93, DOI 10.1002/clc.20416
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Rivera-Fernández R, 2016, J CARDIOVASC MED, V17, P11, DOI 10.2459/JCM.0000000000000015
   ROSSI M, 1989, CLIN SCI, V76, P567, DOI 10.1042/cs0760567
   Rossing P, 2001, DIABETIC MED, V18, P199, DOI 10.1046/j.1464-5491.2001.00446.x
   SCHOUTEN EG, 1991, CIRCULATION, V84, P1516, DOI 10.1161/01.CIR.84.4.1516
   Soydinc S, 2006, ANN NONINVAS ELECTRO, V11, P313, DOI 10.1111/j.1542-474X.2006.00123.x
   Sung KC, 2014, DIABETES RES CLIN PR, V105, P96, DOI 10.1016/j.diabres.2014.04.021
   Tomiyama H, 1998, AM J HYPERTENS, V11, P286, DOI 10.1016/S0895-7061(97)00460-3
   Vrtovec B, 2003, CIRCULATION, V107, P1764, DOI 10.1161/01.CIR.0000057980.84624.95
   Waheed S, 2017, OBES RES CLIN PRACT, V11, P426, DOI 10.1016/j.orcp.2016.09.005
   Wilson PWF, 2005, CIRCULATION, V112, P3066, DOI 10.1161/CIRCULATIONAHA.105.539528
   Wong KYK, 2005, HEART, V91, P1306, DOI 10.1136/hrt.2004.045187
   Yu YX, 2005, AM J MED SCI, V330, P227, DOI 10.1097/00000441-200511000-00005
NR 31
TC 8
Z9 9
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1933-2874
EI 1876-4789
J9 J CLIN LIPIDOL
JI J. Clin. Lipidol.
PD OCT
PY 2018
VL 12
IS 5
BP 1298
EP 1304
DI 10.1016/j.jacl.2018.07.004
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GX5UB
UT WOS:000447815400031
PM 30100158
DA 2025-06-11
ER

PT J
AU Lee, TY
   Martinez-Outschoorn, UE
   Schilder, RJ
   Kim, CH
   Richard, SD
   Rosenblum, NG
   Johnson, JM
AF Lee, Teresa Y.
   Martinez-Outschoorn, Ubaldo E.
   Schilder, Russell J.
   Kim, Christine H.
   Richard, Scott D.
   Rosenblum, Norman G.
   Johnson, Jennifer M.
TI Metformin as a Therapeutic Target in Endometrial Cancers
SO FRONTIERS IN ONCOLOGY
LA English
DT Review
DE tumor microenvironment; metabolism; metformin; endometrial cancer;
   reverse Warburg
ID ACTIVATED PROTEIN-KINASE; METABOLIC SYNDROME; BREAST-CANCER;
   DIABETES-MELLITUS; TUMOR-STROMA; MESENCHYMAL TRANSITION; REPURPOSING
   METFORMIN; CELL-PROLIFERATION; OXIDATIVE STRESS; LACTATE SHUTTLE
AB Endometrial cancer is the most common gynecologic malignancy in developed countries. Its increasing incidence is thought to be related in part to the rise of metabolic syndrome, which has been shown to be a risk factor for the development of hyperestrogenic and hyperinsulinemic states. This has consequently lead to an increase in other hormone-responsive cancers as well e.g., breast and ovarian cancer. The correlation between obesity, hyperglycemia, and endometrial cancer has highlighted the important role of metabolism in cancer establishment and persistence. Tumor-mediated reprogramming of the microenvironment and macroenvironment can range from induction of cytokines and growth factors to stimulation of surrounding stromal cells to produce energy-rich catabolites, fueling the growth, and survival of cancer cells. Such mechanisms raise the prospect of the metabolic microenvironment itself as a viable target for treatment of malignancies. Metformin is a biguanide drug that is a first-line treatment for type 2 diabetes that has beneficial effects on various markers of the metabolic syndrome. Many studies suggest that metformin shows potential as an adjuvant treatment for uterine and other cancers. Here, we review the evidence for metformin as a treatment for cancers of the endometrium. We discuss the available clinical data and the molecular mechanisms by which it may exert its effects, with a focus on how it may alter the tumor microenvironment. The pleiotropic effects of metformin on cellular energy production and usage as well as intercellular and hormone-based interactions make it a promising candidate for reprogramming of the cancer ecosystem. This, along with other treatments aimed at targeting tumor metabolic pathways, may lead to novel treatment strategies for endometrial cancer.
C1 [Lee, Teresa Y.; Martinez-Outschoorn, Ubaldo E.; Schilder, Russell J.; Johnson, Jennifer M.] Thomas Jefferson Univ, Dept Med Oncol, Philadelphia, PA 19107 USA.
   [Kim, Christine H.; Richard, Scott D.; Rosenblum, Norman G.] Thomas Jefferson Univ, Dept Obstet & Gynecol, Philadelphia, PA 19107 USA.
C3 Thomas Jefferson University; Thomas Jefferson University
RP Johnson, JM (corresponding author), Thomas Jefferson Univ, Dept Med Oncol, Philadelphia, PA 19107 USA.
EM jennifer.m.johnson@jefferson.edu
RI Martinet, Wim/I-7375-2015
OI Martinez-Outschoorn, Ubaldo/0000-0003-1483-4551; Lee,
   Teresa/0009-0008-6640-0011
CR Accili D, 2004, CELL, V117, P421, DOI 10.1016/S0092-8674(04)00452-0
   Al Hilli MM, 2016, GYNECOL ONCOL, V140, P270, DOI 10.1016/j.ygyno.2015.11.019
   Anderson KE, 2001, CANCER EPIDEM BIOMAR, V10, P611
   [Anonymous], 2018, FACTS FIG 2018
   [Anonymous], UT NEOPL VERS 1 2018
   Arima R, 2017, GYNECOL ONCOL, V147, P678, DOI 10.1016/j.ygyno.2017.10.014
   Aune D, 2015, ANN ONCOL, V26, P1635, DOI 10.1093/annonc/mdv142
   Barry JA, 2014, HUM REPROD UPDATE, V20, P748, DOI 10.1093/humupd/dmu012
   Becker C, 2013, GYNECOL ONCOL, V129, P565, DOI 10.1016/j.ygyno.2013.03.009
   Bjorge T, 2010, AM J EPIDEMIOL, V171, P892, DOI 10.1093/aje/kwq006
   BOKHMAN JV, 1983, GYNECOL ONCOL, V15, P10, DOI 10.1016/0090-8258(83)90111-7
   Bonuccelli G, 2010, CELL CYCLE, V9, P1960, DOI 10.4161/cc.9.10.11601
   Bray GA, 2009, LANCET, V374, P1677, DOI 10.1016/S0140-6736(09)61457-4
   Byers T, 2015, ENDOCR-RELAT CANCER, V22, pR125, DOI 10.1530/ERC-14-0580
   Byrne FL, 2014, CANCER RES, V74, P5832, DOI 10.1158/0008-5472.CAN-14-0254
   Cai DG, 2016, INT J GYNECOL CANCER, V26, P1667, DOI 10.1097/IGC.0000000000000818
   Calle EE, 2003, NEW ENGL J MED, V348, P1625, DOI 10.1056/NEJMoa021423
   Cantrell LA, 2010, GYNECOL ONCOL, V116, P92, DOI 10.1016/j.ygyno.2009.09.024
   Chae YK, 2016, ONCOTARGET, V7, P40767, DOI 10.18632/oncotarget.8194
   Chandel NS, 2016, CELL METAB, V23, P569, DOI 10.1016/j.cmet.2016.03.010
   Cheong JH, 2011, MOL CANCER THER, V10, P2350, DOI 10.1158/1535-7163.MCT-11-0497
   Chiavarina B, 2010, CELL CYCLE, V9, P3534, DOI 10.4161/cc.9.17.12908
   Coperchini F, 2015, J ENDOCRINOL INVEST, V38, P1047, DOI 10.1007/s40618-015-0370-z
   Curry J, 2017, LARYNGOSCOPE, V127, P1808, DOI 10.1002/lary.26489
   Cust AE, 2007, ENDOCR-RELAT CANCER, V14, P755, DOI 10.1677/ERC-07-0132
   del Carmen MG, 2012, GYNECOL ONCOL, V127, P651, DOI 10.1016/j.ygyno.2012.09.012
   Dong LL, 2012, J OBSTET GYNAECOL RE, V38, P1077, DOI 10.1111/j.1447-0756.2011.01839.x
   Dossus L, 2013, AM J EPIDEMIOL, V177, P787, DOI 10.1093/aje/kws309
   Dowling RJO, 2007, CANCER RES, V67, P10804, DOI 10.1158/0008-5472.CAN-07-2310
   Duska LR, 2001, GYNECOL ONCOL, V83, P388, DOI 10.1006/gyno.2001.6434
   El-Mir MY, 2000, J BIOL CHEM, V275, P223, DOI 10.1074/jbc.275.1.223
   Esposito K, 2014, ENDOCRINE, V45, P28, DOI 10.1007/s12020-013-9973-3
   Esposito K, 2012, DIABETES CARE, V35, P2402, DOI 10.2337/dc12-0336
   Ezewuiro O, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0147145
   Febbraro T, 2014, GYNECOL ONCOL, V135, P614, DOI 10.1016/j.ygyno.2014.10.011
   Fiaschi T, 2012, CANCER RES, V72, P5130, DOI 10.1158/0008-5472.CAN-12-1949
   Fitzmaurice C, 2017, JAMA ONCOL, V3, P524, DOI [10.1001/jamaoncol.2018.2706, 10.1001/jamaoncol.2016.5688]
   Fitzmaurice C, 2015, JAMA ONCOL, V1, P505, DOI 10.1001/jamaoncol.2015.0735
   Franchi M, 2017, EUR J CANCER PREV, V26, P225, DOI 10.1097/CEJ.0000000000000235
   Friberg E, 2007, DIABETOLOGIA, V50, P1365, DOI 10.1007/s00125-007-0681-5
   Friedenreich CM, 2011, CANCER EPIDEM BIOMAR, V20, P2384, DOI 10.1158/1055-9965.EPI-11-0715
   Fu YJ, 2017, ONCOTARGET, V8, P57813, DOI 10.18632/oncotarget.18175
   Gong J, 2016, TARGET ONCOL, V11, P447, DOI 10.1007/s11523-016-0423-z
   Goodwin ML, 2014, CANCER CELL, V26, P851, DOI 10.1016/j.ccell.2014.10.003
   Gupta SC, 2013, TRENDS PHARMACOL SCI, V34, P508, DOI 10.1016/j.tips.2013.06.005
   Hall C, 2016, INT J GYNECOL CANCER, V26, P313, DOI 10.1097/IGC.0000000000000603
   Han JJ, 2015, GYNECOL ONCOL, V138, P668, DOI 10.1016/j.ygyno.2015.06.036
   Hanna RK, 2012, GYNECOL ONCOL, V125, P458, DOI 10.1016/j.ygyno.2012.01.009
   Harwood HJ, 2003, J BIOL CHEM, V278, P37099, DOI 10.1074/jbc.M304481200
   Hernandez AV, 2015, EUR J CANCER, V51, P2747, DOI 10.1016/j.ejca.2015.08.031
   Humber CE, 2007, ANN ONCOL, V18, P409, DOI 10.1093/annonc/mdl417
   Iglesias DA, 2013, MOL CANCER THER, V12, P2847, DOI 10.1158/1535-7163.MCT-13-0439
   Imai A, 2015, ONCOL LETT, V10, P577, DOI 10.3892/ol.2015.3262
   Irie H, 2016, ONCOL LETT, V11, P1287, DOI 10.3892/ol.2016.4075
   Karnevi E, 2013, BMC CANCER, V13, DOI 10.1186/1471-2407-13-235
   KILGORE LC, 1995, GYNECOL ONCOL, V56, P29, DOI 10.1006/gyno.1995.1005
   Kim EH, 2017, NEURO-ONCOLOGY, V19, P197, DOI 10.1093/neuonc/now174
   Ko EM, 2015, GYNECOL ONCOL, V136, P341, DOI 10.1016/j.ygyno.2014.12.001
   Ko EM, 2014, GYNECOL ONCOL, V132, P438, DOI 10.1016/j.ygyno.2013.11.021
   Ko YH, 2011, CANCER BIOL THER, V12, P1085, DOI 10.4161/cbt.12.12.18671
   Kong A, 2012, JNCI-J NATL CANCER I, V104, P1625, DOI 10.1093/jnci/djs374
   Laskov I, 2016, INT J GYNECOL CANCER, V26, P1213, DOI 10.1097/IGC.0000000000000761
   Laskov I, 2014, GYNECOL ONCOL, V134, P607, DOI 10.1016/j.ygyno.2014.06.014
   Latif A, 2017, BMC CLIN PATHOL, V17, DOI 10.1186/s12907-017-0067-7
   Lemanska A, 2015, GINEKOL POL, V86, P419
   Li X, 2014, J CANCER, V5, P173, DOI 10.7150/jca.8009
   Liao CY, 2014, GYNECOL ONCOL, V135, P163, DOI 10.1016/j.ygyno.2014.07.095
   Liu Z, 2016, ONCOTARGET, V7, P21315, DOI 10.18632/oncotarget.7040
   Luo J, 2014, BRIT J CANCER, V111, P1432, DOI 10.1038/bjc.2014.407
   Machado AD, 2016, ONCOL LETT, V12, P3626, DOI 10.3892/ol.2016.5041
   Markowska A, 2013, DIABETOL METAB SYNDR, V5, DOI 10.1186/1758-5996-5-76
   Martinez-Outschoorn UE, 2010, CELL CYCLE, V9, P3256, DOI 10.4161/cc.9.16.12553
   Matsuzaki H, 2003, P NATL ACAD SCI USA, V100, P11285, DOI 10.1073/pnas.1934283100
   Meireles CG, 2017, GYNECOL ONCOL, V147, P167, DOI 10.1016/j.ygyno.2017.07.120
   Mitsuhashi A, 2016, ANN ONCOL, V27, P262, DOI 10.1093/annonc/mdv539
   Mitsuhashi A, 2014, CANCER-AM CANCER SOC, V120, P2986, DOI 10.1002/cncr.28853
   Moir-Meyer GL, 2015, HUM GENET, V134, P269, DOI 10.1007/s00439-014-1507-4
   MOORE TD, 1991, J CLIN ONCOL, V9, P1071, DOI 10.1200/JCO.1991.9.6.1071
   Morice P, 2016, LANCET, V387, P1094, DOI 10.1016/S0140-6736(15)00130-0
   Nevadunsky NS, 2014, GYNECOL ONCOL, V132, P236, DOI 10.1016/j.ygyno.2013.10.026
   Ni J, 2015, CLIN TRANSL ONCOL, V17, P835, DOI 10.1007/s12094-015-1309-8
   Nieman KM, 2011, NAT MED, V17, P1498, DOI 10.1038/nm.2492
   Ning JY, 2010, MOL ENDOCRINOL, V24, P1218, DOI 10.1210/me.2009-0474
   Nout RA, 2010, LANCET, V375, P816, DOI 10.1016/S0140-6736(09)62163-2
   Owen MR, 2000, BIOCHEM J, V348, P607, DOI 10.1042/0264-6021:3480607
   Pavlides S, 2010, AGING-US, V2, P185, DOI 10.18632/aging.100134
   Pavlides S, 2009, CELL CYCLE, V8, P3984, DOI 10.4161/cc.8.23.10238
   Pierotti MA, 2013, ONCOGENE, V32, P1475, DOI 10.1038/onc.2012.181
   Pryor R, 2015, BIOCHEM J, V471, P307, DOI 10.1042/BJ20150497
   Quinn BJ, 2013, CANCER PREV RES, V6, P801, DOI 10.1158/1940-6207.CAPR-13-0058-T
   Quinn MA, 1999, HEMATOL ONCOL CLIN N, V13, P163, DOI 10.1016/S0889-8588(05)70159-3
   Rivadeneira DB, 2018, CLIN CANCER RES, V24, P2473, DOI 10.1158/1078-0432.CCR-17-0894
   Romero IL, 2015, CLIN CANCER RES, V21, P680, DOI 10.1158/1078-0432.CCR-14-2198
   Rosato V, 2011, ANN ONCOL, V22, P884, DOI 10.1093/annonc/mdq464
   Russo A, 2008, EUR J CANCER, V44, P293, DOI 10.1016/j.ejca.2007.11.005
   Sarfstein R, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061537
   Scharping NE, 2017, CANCER IMMUNOL RES, V5, P9, DOI 10.1158/2326-6066.CIR-16-0103
   Schrauwen S, 2015, GYNECOL ONCOL, V138, P378, DOI 10.1016/j.ygyno.2015.06.006
   Schuler KM, 2015, CANCER MED-US, V4, P161, DOI 10.1002/cam4.353
   Secord AA, 2016, GYNECOL ONCOL, V140, P184, DOI 10.1016/j.ygyno.2015.10.020
   Seebacher V, 2016, EUR J OBSTET GYN R B, V203, P291, DOI 10.1016/j.ejogrb.2016.06.013
   Shaw RJ, 2005, SCIENCE, V310, P1642, DOI 10.1126/science.1120781
   Sivalingam VN, 2016, BRIT J CANCER, V114, P281, DOI 10.1038/bjc.2015.453
   Soliman PT, 2016, GYNECOL ONCOL, V143, P466, DOI 10.1016/j.ygyno.2016.10.011
   Sousa CM, 2016, NATURE, V536, P479, DOI 10.1038/nature19084
   Stephenne X, 2011, DIABETOLOGIA, V54, P3101, DOI 10.1007/s00125-011-2311-5
   Stocks T, 2015, INT J EPIDEMIOL, V44, P1353, DOI 10.1093/ije/dyv001
   Tabrizi AD, 2014, ASIAN PAC J CANCER P, V15, P10067, DOI 10.7314/APJCP.2014.15.23.10067
   Takahashi A, 2014, CANCER CELL INT, V14, DOI 10.1186/1475-2867-14-53
   Tan BK, 2011, J CLIN ENDOCR METAB, V96, P808, DOI 10.1210/jc.2010-1803
   Tang YL, 2017, BIOMED RES INT, V2017, DOI 10.1155/2017/5905384
   Tierney BJ, 2014, GYNECOL ONCOL, V135, P133, DOI 10.1016/j.ygyno.2014.07.087
   Trabert B, 2015, CANCER EPIDEM BIOMAR, V24, P261, DOI 10.1158/1055-9965.EPI-14-0923
   Tseng CH, 2015, GYNECOL ONCOL, V138, P147, DOI 10.1016/j.ygyno.2015.03.059
   Uehara T, 2015, ONCOL REP, V33, P744, DOI 10.3892/or.2014.3611
   Viollet B, 2012, CLIN SCI, V122, P253, DOI 10.1042/CS20110386
   Wallbillich JJ, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0170318
   Wang JC, 2018, J CELL MOL MED, V22, P3825, DOI 10.1111/jcmm.13655
   Wang Y, 2018, J EXP CLIN CANC RES, V37, DOI 10.1186/s13046-018-0731-5
   Warburg O, 1927, J GEN PHYSIOL, V8, P519, DOI 10.1085/jgp.8.6.519
   Whitaker-Menezes D, 2011, CELL CYCLE, V10, P1772, DOI 10.4161/cc.10.11.15659
   Wise MR, 2016, AM J OBSTET GYNECOL, V214, DOI 10.1016/j.ajog.2016.01.175
   Würth R, 2016, DRUG DISCOV TODAY, V21, P190, DOI 10.1016/j.drudis.2015.09.017
   Xie Y, 2014, ONCOL LETT, V8, P1993, DOI 10.3892/ol.2014.2466
   Xie Y, 2011, J STEROID BIOCHEM, V126, P113, DOI 10.1016/j.jsbmb.2010.12.006
   Yuan J, 2015, SCI REP-UK, V5, DOI 10.1038/srep17663
   Yun H, 2014, FEBS J, V281, P4421, DOI 10.1111/febs.12949
   Zhang JB, 2017, ONCOL LETT, V14, P4949, DOI 10.3892/ol.2017.6877
   Zhang Y, 2010, GYNECOL ONCOL, V117, P41, DOI 10.1016/j.ygyno.2009.12.029
   Zhang Yu, 2015, Asian Pac J Cancer Prev, V16, P221
   Zhang ZJ, 2014, DIABETES OBES METAB, V16, P707, DOI 10.1111/dom.12267
   Zhang ZB, 2011, INT J GYNECOL CANCER, V21, P213, DOI 10.1097/IGC.0b013e318207dac7
   Zhao LJ, 2013, HUM REPROD, V28, P1324, DOI 10.1093/humrep/det042
   Zhao Y, 2018, GYNECOL ENDOCRINOL, V34, P428, DOI 10.1080/09513590.2017.1409714
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI13505
   Zhuo ZH, 2016, ARCH GYNECOL OBSTET, V294, P1055, DOI 10.1007/s00404-016-4148-0
   Zou JF, 2016, CANCER SCI, V107, P1806, DOI 10.1111/cas.13083
NR 137
TC 62
Z9 64
U1 1
U2 23
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD AUG 28
PY 2018
VL 8
AR 341
DI 10.3389/fonc.2018.00341
PG 14
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA GR7HL
UT WOS:000442859600002
PM 30211120
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, S
   Song, Y
   Lee, JE
   Jun, S
   Shin, S
   Wie, GA
   Cho, YH
   Joung, H
AF Kim, Subeen
   Song, YoonJu
   Lee, Jung Eun
   Jun, Shinyoung
   Shin, Sangah
   Wie, Gyung-Ah
   Cho, Yoon Hee
   Joung, Hyojee
TI Total Antioxidant Capacity from Dietary Supplement Decreases the
   Likelihood of Having Metabolic Syndrome in Korean Adults
SO NUTRIENTS
LA English
DT Article
DE dietary supplements; antioxidant vitamins; total antioxidant capacity;
   metabolic syndrome; Korean adults
ID NUTRITION EXAMINATION SURVEY; RANDOMIZED CONTROLLED-TRIAL; HEALTHY-YOUNG
   ADULTS; C-REACTIVE PROTEIN; SERUM VITAMIN-A; OXIDATIVE STRESS;
   NATIONAL-HEALTH; US ADULTS; BETA-CAROTENE; CENTRAL ADIPOSITY
AB This study was conducted to estimate antioxidant vitamin intake and total antioxidant capacity (TAC) from diet and dietary supplements and to examine their association with metabolic syndrome (MetS) in Korean adults. Out of 6308 adults 19 similar to 64 years old from the 2010 similar to 2011 Korea National Health and Nutrition Examination Survey, 1847 adults were classified as dietary supplement users and the other 4461 adults were classified as non-users. Antioxidant intake and TAC from diet and dietary supplements were estimated using dietary intake data and linked with the antioxidant and TAC database for common Korean foods. The prevalence of MetS was lower in dietary supplement users (odds ratio (OR) = 0.82; 95% confidence interval (CI), 0.68-0.98) than that in non-users. Among dietary supplement users, a lower prevalence of MetS was observed in the highest tertile for vitamin A (OR = 0.72; 95% CI, 0.53-0.99) and vitamin E (OR = 0.74; 95% CI, 0.55-0.99) intake than that in the lowest tertile among non-users. Subjects in the highest tertile of TAC among dietary supplement users showed a lower prevalence of MetS (OR = 0.72; 95% CI, 0.52-0.99) than non-users. The results imply that intake of vitamin A, vitamin E, and TAC from dietary supplements might have a protective effect on MetS among Korean adults.
C1 [Kim, Subeen; Joung, Hyojee] Seoul Natl Univ, Grad Sch Publ Hlth, Dept Publ Hlth, Seoul 08826, South Korea.
   [Song, YoonJu] Catholic Univ Korea, Sch Human Ecol, Food & Nutr, Bucheon 14662, South Korea.
   [Lee, Jung Eun] Seoul Natl Univ, Coll Human Ecol, Dept Food & Nutr, Seoul 08826, South Korea.
   [Jun, Shinyoung] Purdue Univ, Dept Nutr Sci, W Lafayette, IN 47907 USA.
   [Shin, Sangah] Chung Ang Univ, Dept Food & Nutr, Gyeonggi Do 17546, South Korea.
   [Wie, Gyung-Ah] Natl Canc Ctr, Res Inst & Hosp, Dept Clin Nutr, Goyang Si 10408, South Korea.
   [Cho, Yoon Hee] Univ Montana, Dept Biomed & Pharmaceut Sci, Missoula, MT 59812 USA.
   [Joung, Hyojee] Seoul Natl Univ, Inst Hlth & Environm, Seoul 08826, South Korea.
C3 Seoul National University (SNU); Catholic University of Korea; Seoul
   National University (SNU); Purdue University System; Purdue University;
   Chung Ang University; National Cancer Center - Korea (NCC); University
   of Montana System; University of Montana; Seoul National University
   (SNU)
RP Joung, H (corresponding author), Seoul Natl Univ, Grad Sch Publ Hlth, Dept Publ Hlth, Seoul 08826, South Korea.; Joung, H (corresponding author), Seoul Natl Univ, Inst Hlth & Environm, Seoul 08826, South Korea.
EM subeen2466@snu.ac.kr; yjsong@catholic.ac.kr; jungelee@snu.ac.kr;
   jun24@purdue.edu; ivory8320@cau.ac.kr; gawie@ncc.re.kr;
   yoonhee.cho@umontana.edu; hjjoung@snu.ac.kr
RI Lee, Jung/AAC-5634-2020; Song, YoonJu/ABF-4594-2021; Cho,
   Yoon/AAN-6560-2021; Jun, Shinyoung/MUO-2043-2025; Joung,
   Hyojee/AAU-9502-2020; Stefanadis, Christodoulos/ABH-2232-2020
OI Wie, Gyung Ah/0000-0002-1503-3177; Song, YoonJu/0000-0002-4764-5864;
   Stefanadis, Christodoulos/0000-0001-5974-6454; Jun,
   Shinyoung/0000-0003-2452-4709; Cho, Yoon Hee/0000-0002-4290-7140; Lee,
   Jung Eun/0000-0003-1141-878X; Joung, Hyojee/0000-0003-1182-7786
FU 'Research Program for Agricultural Science and Technology Development',
   National Academy of Agricultural Science, Rural Development
   Administration [PJ011637022017]
FX This work was carried out with the support of 'Research Program for
   Agricultural Science and Technology Development', National Academy of
   Agricultural Science, Rural Development Administration (Project No.
   PJ011637022017).
CR Actis-Goretta L, 2004, CLIN CHIM ACTA, V349, P97, DOI 10.1016/j.cccn.2004.06.009
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   [Anonymous], 2011, BRIT J NUTR, DOI DOI 10.1017/S0007114511000109
   Bechor S, 2016, NUTRIENTS, V8, DOI 10.3390/nu8070435
   Beydoun MA, 2011, J NUTR, V141, P903, DOI 10.3945/jn.110.136580
   Tran BT, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-016-3936-6
   Bjorklund G, 2017, NUTRITION, V33, P311, DOI 10.1016/j.nut.2016.07.018
   Bohn T, 2015, MOL NUTR FOOD RES, V59, P1307, DOI 10.1002/mnfr.201400745
   Brighenti F, 2005, BRIT J NUTR, V93, P619, DOI 10.1079/BJN20051400
   Chun OK, 2010, J NUTR, V140, P317, DOI 10.3945/jn.109.114413
   Czernichow S, 2009, AM J CLIN NUTR, V90, P329, DOI 10.3945/ajcn.2009.27635
   Del Rio D, 2011, J NUTR, V141, P118, DOI 10.3945/jn.110.125120
   Edwardson CL, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034916
   Farhangi MA, 2013, ANN CLIN BIOCHEM, V50, P25, DOI 10.1258/acb.2012.012096
   Farooq Wajiha, 2015, Oman Med J, V30, P100, DOI 10.5001/omj.2015.22
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Fujita K, 2006, CIRC J, V70, P1437, DOI 10.1253/circj.70.1437
   Godala MM, 2016, ADV CLIN EXP MED, V25, P689, DOI 10.17219/acem/41049
   Gregório BM, 2016, CURR PHARM DESIGN, V22, P859, DOI 10.2174/1381612822666151209152352
   Grundy SM, 2006, CURR OPIN CARDIOL, V21, P1, DOI 10.1097/01.hco.0000200416.65370.a0
   Guillén S, 2017, FOOD CHEM, V217, P209, DOI 10.1016/j.foodchem.2016.08.067
   Gunanti IR, 2014, J NUTR, V144, P489, DOI 10.3945/jn.113.183137
   Hercberg S, 2004, ARCH INTERN MED, V164, P2335, DOI 10.1001/archinte.164.21.2335
   Hermsdorff HHM, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-59
   Jeyakumar SM, 2015, INDIAN J MED RES, V141, P275, DOI 10.4103/0971-5916.156554
   Jialal I, 2005, J NUTR, V135, P348, DOI 10.1093/jn/135.2.348
   Jun S., 2017, EUR J NUTR
   Jun S, 2016, BRIT J NUTR, V115, P480, DOI 10.1017/S0007114515004006
   Kang M, 2014, EUR J CLIN NUTR, V68, P804, DOI 10.1038/ejcn.2014.77
   Keane D, 2013, CURR VASC PHARMACOL, V11, P842, DOI 10.2174/15701611113116660173
   Kim HS, 2000, BIOCHEM BIOPH RES CO, V270, P76, DOI 10.1006/bbrc.2000.2373
   Kim K, 2016, NUTRIENTS, V8, DOI 10.3390/nu8010015
   Kim M. S., 2004, THESIS
   Kim SeongAh Kim SeongAh, 2016, Journal of Nutrition and Health, V49, P258
   Kofoed CLF, 2015, BRIT J NUTR, V113, P1993, DOI 10.1017/S0007114515001440
   Korean Society for the Study of Obesity, 2012, MAN OB, P130
   Lim S, 2011, DIABETES CARE, V34, P1323, DOI 10.2337/dc10-2109
   Limberg JK, 2013, AM J PHYSIOL-HEART C, V305, pH1230, DOI 10.1152/ajpheart.00291.2013
   Liu SM, 1999, JAMA-J AM MED ASSOC, V282, P1073, DOI 10.1001/jama.282.11.1073
   Lonn E, 2002, DIABETES CARE, V25, P1919, DOI 10.2337/diacare.25.11.1919
   Ministry of Health and Welfare Korea Centers for Disease Control and Prevention, 2016, KOR HLTH STAT 2015
   Mooradian AD, 2014, AM J CARDIOVASC DRUG, V14, P253, DOI 10.1007/s40256-014-0068-1
   Psaltopoulou T, 2011, NUTR METAB CARDIOVAS, V21, P561, DOI 10.1016/j.numecd.2009.11.005
   Radimer K, 2004, AM J EPIDEMIOL, V160, P339, DOI 10.1093/aje/kwh207
   Sacco M, 2003, DIABETES CARE, V26, P3264, DOI 10.2337/diacare.26.12.3264
   Shaish A, 2006, ATHEROSCLEROSIS, V189, P215, DOI 10.1016/j.atherosclerosis.2005.12.004
   Soory Mena, 2012, Infectious Disorders - Drug Targets, V12, P388
   Stephens NG, 1996, LANCET, V347, P781, DOI 10.1016/S0140-6736(96)90866-1
   Sun K, 2014, CLIN NUTR, V33, P596, DOI 10.1016/j.clnu.2013.10.003
   Sun YY, 2012, NUTR RES, V32, P328, DOI 10.1016/j.nutres.2012.03.012
   Tetens I, 2011, FOOD NUTR RES, V55
   Valtuena S, 2008, AM J CLIN NUTR, V87, P1290, DOI 10.1093/ajcn/87.5.1290
   Viroonudomphol D, 2003, ASIA PAC J CLIN NUTR, V12, P73
   Wallström P, 2001, AM J CLIN NUTR, V73, P777
   Wang QZ, 2010, INT J VITAM NUTR RES, V80, P178, DOI 10.1024/0300-9831/a000015
   Wei XP, 2016, ASIA PAC J CLIN NUTR, V25, P563, DOI 10.6133/apjcn.092015.03
   Wen LR, 2017, ANN NY ACAD SCI, V1398, P120, DOI 10.1111/nyas.13350
   Zulet MA, 2008, J NUTR SCI VITAMINOL, V54, P347, DOI 10.3177/jnsv.54.347
NR 58
TC 31
Z9 31
U1 2
U2 8
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2017
VL 9
IS 10
AR 1055
DI 10.3390/nu9101055
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FM0DM
UT WOS:000414629900011
PM 28937597
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Obadia, N
   Lessa, MA
   Daliry, A
   Silvares, RR
   Gomes, F
   Tibiriçá, E
   Estato, V
AF Obadia, Nathalie
   Lessa, Marcos Adriano
   Daliry, Anissa
   Silvares, Raquel Rangel
   Gomes, Fabiana
   Tibirica, Eduardo
   Estato, Vanessa
TI Cerebral microvascular dysfunction in metabolic syndrome is exacerbated
   by ischemia-reperfusion injury
SO BMC NEUROSCIENCE
LA English
DT Article
DE Metabolic syndrome; Laser speckle contrast imaging (LSCI); Cerebral
   microvascular blood flow; Ischemia and reperfusion
ID HIGH-FAT DIET; ADIPOSE-TISSUE; INSULIN-RESISTANCE; BLOOD-FLOW;
   DEFINITION; STROKE; IMPACT; ATTACK; RISK; RATS
AB Background: Metabolic syndrome (MetS) is associated with an increased risk of cerebrovascular diseases, including cerebral ischemia. Microvascular dysfunction is an important feature underlying the pathophysiology of cerebrovascular diseases. In this study, we aimed to investigate the impacts of ischemia and reperfusion (IR) injury on the cerebral microvascular function of rats with high-fat diet-induced MetS.
   Results: We examined Wistar rats fed a high-fat diet (HFD) or normal diet (CTL) for 20 weeks underwent 30 min of bilateral carotid artery occlusion followed by 1 h of reperfusion (IR) or sham surgery. Microvascular blood flow was evaluated on the parietal cortex surface through a cranial window by laser speckle contrast imaging, functional capillary density, endothelial function and endothelial-leukocyte interactions by intravital videomicroscopy. Lipid peroxidation was assessed by TBARs analysis, the expression of oxidative enzymes and inflammatory markers in the brain tissue was analyzed by real-time PCR. The cerebral IR in MetS animals induced a functional capillary rarefaction (HFD IR 117 +/- 17 vs. CTL IR 224 +/- 35 capillary/mm(2); p < 0.05), blunted the endothelial response to acetylcholine (HFD IR -16.93% vs. CTL IR 16.19% from baseline inner diameter p < 0.05) and increased the endothelial-leukocyte interactions in the venules in the brain. The impact of ischemia on the cerebral microvascular blood flow was worsened in MetS animals, with a marked reduction of cerebral blood flow, exposing brain tissue to a higher state of hypoxia.
   Conclusions: Our results demonstrate that during ischemia and reperfusion, animals with MetS are more susceptible to alterations in the cerebral microcirculation involving endothelial dysfunction and oxidative stress events.
C1 [Obadia, Nathalie; Lessa, Marcos Adriano; Daliry, Anissa; Silvares, Raquel Rangel; Gomes, Fabiana; Tibirica, Eduardo; Estato, Vanessa] Fundacao Oswaldo Cruz, Lab Cardiovasc Invest, Ave Brasil 4365, BR-21045900 Rio De Janeiro, RJ, Brazil.
   [Tibirica, Eduardo] Natl Inst Cardiol, Rio De Janeiro, Brazil.
   [Estato, Vanessa] Fundacao Oswaldo Cruz, Inst Drug Technol, Rio De Janeiro, Brazil.
C3 Fundacao Oswaldo Cruz; Fundacao Oswaldo Cruz
RP Estato, V (corresponding author), Fundacao Oswaldo Cruz, Lab Cardiovasc Invest, Ave Brasil 4365, BR-21045900 Rio De Janeiro, RJ, Brazil.
EM estato@ioc.fiocruz.br
RI Daliry, Anissa/F-6256-2014; Estato, Vanessa/AAJ-9060-2020; lessa,
   marcos/JAC-2591-2023
OI Lessa, Marcos/0000-0002-4079-5704; Daliry, Anissa/0000-0001-7303-0030
FU CNPq, Rio de Janeiro, Brazil; FAPERJ, Rio de Janeiro, Brazil; FIOCRUZ,
   Rio de Janeiro, Brazil
FX Support was provided by CNPq, FAPERJ and FIOCRUZ, Rio de Janeiro,
   Brazil.
CR [Anonymous], 2016, Oxid. Med. Cell Longev
   Aoqui C, 2014, CARDIOVASC DIABETOL, V13, DOI 10.1186/1475-2840-13-31
   Arcaro G, 2002, CIRCULATION, V105, P576, DOI 10.1161/hc0502.103333
   Carvalho-Tavares J, 2000, CIRC RES, V87, P1141, DOI 10.1161/01.RES.87.12.1141
   Chantler PD, 2015, MICROCIRCULATION, V22, P435, DOI 10.1111/micc.12209
   Costa RRS, 2011, MICROVASC RES, V82, P416, DOI 10.1016/j.mvr.2011.08.007
   Czernichow S, 2010, HYPERTENS RES, V33, P293, DOI 10.1038/hr.2009.228
   DIRNAGL U, 1994, STROKE, V25, P1028, DOI 10.1161/01.STR.25.5.1028
   DRAPER HH, 1990, METHOD ENZYMOL, V186, P421
   Ducan BB, 2005, REV HCPA, V25, P5
   EKLOF B, 1973, ACTA PHYSIOL SCAND, V87, P69, DOI 10.1111/j.1748-1716.1973.tb05367.x
   Eltzschig HK, 2011, NAT MED, V17, P1391, DOI 10.1038/nm.2507
   Estato V, 2013, MICROVASC RES, V87, P41, DOI 10.1016/j.mvr.2013.02.007
   Gao DK, 2011, MED HYPOTHESES, V76, P911, DOI 10.1016/j.mehy.2011.03.007
   Giorgino F, 2005, ACTA PHYSIOL SCAND, V183, P13, DOI 10.1111/j.1365-201X.2004.01385.x
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Humeau-Heurtier A, 2015, MICROVASC RES, V98, P54, DOI 10.1016/j.mvr.2014.12.003
   Ishikawa M, 2004, FRONT BIOSCI-LANDMRK, V9, P1339, DOI 10.2741/1330
   Koren-Morag N, 2005, STROKE, V36, P1366, DOI 10.1161/01.STR.0000169945.75911.33
   Lakhan Shaheen E, 2009, J Transl Med, V7, P97, DOI 10.1186/1479-5876-7-97
   Lam DW., 2000, Endotext
   Lapi D, 2012, FRONT PHYSIOL, V3, DOI 10.3389/fphys.2012.00099
   LERMAN A, 1992, CIRCULATION, V86, P12
   Li MN, 2013, YONSEI MED J, V54, P283, DOI 10.3349/ymj.2013.54.2.283
   Li ZX, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0154990
   Liu H, 2015, AM J MED SCI, V350, P204, DOI 10.1097/MAJ.0000000000000540
   Liu JK, 2010, J CLIN ENDOCR METAB, V95, P5419, DOI 10.1210/jc.2010-1378
   Lynch CM, 2013, STROKE, V44, P3195, DOI 10.1161/STROKEAHA.113.001366
   Mohamed-Ali V, 1998, INT J OBESITY, V22, P1145, DOI 10.1038/sj.ijo.0800770
   Molina CA, 2009, CEREBROVASC DIS, V27, P162, DOI 10.1159/000200455
   Muniz Luiz Roberto Franklin, 2004, Acta Cir. Bras., V19, P529
   Nascimento AR, 2013, OBESITY, V21, P2046, DOI 10.1002/oby.20358
   Nazzaro P, 2013, EUR J INTERN MED, V24, P183, DOI 10.1016/j.ejim.2012.08.017
   OKADA Y, 1994, STROKE, V25, P202, DOI 10.1161/01.STR.25.1.202
   Ouwens DM, 2005, DIABETOLOGIA, V48, P1229, DOI 10.1007/s00125-005-1755-x
   Panahpour Hamdollah, 2014, Iranian Biomedical Journal, V18, P232, DOI 10.6091/ibj.13672.2014
   Rock RB, 2004, CLIN MICROBIOL REV, V17, P942, DOI 10.1128/CMR.17.4.942-964.2004
   Sacco RL, 2013, STROKE, V44, P2064, DOI 10.1161/STR.0b013e318296aeca
   Shah ZA, 2005, J ETHNOPHARMACOL, V101, P299, DOI 10.1016/j.jep.2005.05.002
   Uchida Y, 2012, CIRC J, V76, P1972, DOI 10.1253/circj.CJ-11-1299
   van Rooy MJ, 2015, THROMB RES, V135, P434, DOI 10.1016/j.thromres.2014.12.030
   VILLRINGER A, 1991, MICROVASC RES, V42, P305, DOI 10.1016/0026-2862(91)90064-I
   Yang T, 2017, AGEING RES REV, V34, P15, DOI 10.1016/j.arr.2016.09.007
   Yasuda Y, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-70
NR 44
TC 28
Z9 28
U1 1
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2202
J9 BMC NEUROSCI
JI BMC Neurosci.
PD SEP 8
PY 2017
VL 18
AR 67
DI 10.1186/s12868-017-0384-x
PG 10
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA FG2DB
UT WOS:000409889300002
PM 28886695
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pérez-Martínez, P
   García-Ríos, A
   Delgado-Lista, J
   Pérez-Jiménez, F
   López-Miranda, J
AF Perez-Martinez, Pablo
   Garcia-Rios, Antonio
   Delgado-Lista, Javier
   Perez-Jimenez, Francisco
   Lopez-Miranda, Jose
TI Mediterranean Diet Rich in Olive Oil and Obesity, Metabolic Syndrome and
   Diabetes Mellitus
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Mediterranean diet; olive oil; metabolic syndrome; diabetes mellitus;
   obesity; functional food; phenolic compounds; inflammation; oxidative
   stress
ID NF-KAPPA-B; RANDOMIZED CONTROLLED-TRIAL; POSTPRANDIAL ENDOTHELIAL
   FUNCTION; MONOUNSATURATED FATTY-ACIDS; CARDIOVASCULAR RISK-FACTORS;
   INSULIN-RESISTANT SUBJECTS; CORONARY-HEART-DISEASE; SUN PROSPECTIVE
   COHORT; BROWN ADIPOSE-TISSUE; BODY-MASS INDEX
AB After decades of epidemiological, clinical and experimental research, it has become clear that consumption of Mediterranean dietary patterns rich in olive oil has a profound influence on health outcomes, including obesity, metabolic syndrome (MetS) and diabetes mellitus. Traditionally, many beneficial properties associated with this oil have been ascribed to its high oleic acid content. Olive oil, however, is a functional food that, besides having high-monounsaturated (MUFA) content, contains other minor components with biological properties. In this line, phenolic compounds have shown antioxidant and antiinflammatory properties, prevent lipoperoxidation, induce favorable changes of lipid profile, improve endothelial function, and disclose antithrombotic properties. Research into the pharmacological properties of the minor components of olive oil is very active and could lead to the formulation of functional food and nutraceuticals. Although more data are mandatory the Mediterranean diet rich in olive oil does not contribute to obesity and appears to be a useful tool in the lifestyle management of the MetS. Moreover there is good scientific support for MUFA diets, especially those based on olive oil, as an alternative approach to low-fat diets for the medical nutritional therapy in diabetes. The objective of this review is to present evidence illustrating the relationship between Mediterranean diet, olive oil and metabolic diseases, including obesity, MetS and diabetes mellitus and to discuss potential mechanisms by which this food can help in disease prevention and treatment.
C1 [Lopez-Miranda, Jose] Univ Cordoba, Reina Sofia Univ Hospital, IMIBIC, Lipid & Atherosclerosis Unit, E-14071 Cordoba, Spain.
   [Lopez-Miranda, Jose] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
C3 Universidad de Cordoba; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN; Instituto de Salud Carlos III
RP López-Miranda, J (corresponding author), Univ Cordoba, Reina Sofia Univ Hospital, IMIBIC, Lipid & Atherosclerosis Unit, E-14071 Cordoba, Spain.
EM jlopezmir@uco.es
RI Lopez-Miranda, Jose/Y-8306-2019; Delgado-Lista, Javier/KAM-7412-2024;
   Jimenez, Francisco/AAJ-9559-2021; Tejada, Silvia/L-7297-2014; Perez
   Martinez, Pablo/AEL-6176-2022
OI Perez-Jimenez, Francisco/0000-0001-7499-7681; Perez Martinez,
   Pablo/0000-0001-7716-8117; Lopez-Miranda, Jose/0000-0002-8844-0718;
   Perez Jimenez, Francisco/0000-0001-9808-1280; Delgado Lista, Francisco
   Javier/0000-0002-2982-2716
FU Spanish Ministry of Science and Innovation [AGL2006-01979/ALI,
   AGL2009-12270, SAF2007/62005, PI10/01041]; Consejeria de Economia,
   Innovacion y Ciencia, Proyectos de Investigacion de Excelencia, Junta de
   Andalucia [CT5015, P06-CTS-01425]; Consejeria de Salud, Junta de
   Andalucia [07/43, PI 0193/09, PI-0252/2009, PI-0058-2010]; Centro de
   Excelencia Investigadora en Aceite de Oliva y Salud (CEAS); FEDER, Fondo
   Social Europeo; ISCIII
FX Ciber Fisiopatologia Obesidad y Nutricion, CIBEROBN, is an initiative of
   ISCIII government of Spain. This study was supported in part by research
   grants from the Spanish Ministry of Science and Innovation
   (AGL2006-01979/ALI, AGL2009-12270 to JL-M, SAF2007/62005 to FP-J and
   PI10/01041 to PP-M), Consejeria de Economia, Innovacion y Ciencia,
   Proyectos de Investigacion de Excelencia, Junta de Andalucia (CT5015 to
   FP-J and P06-CTS-01425 to JL-M); Consejeria de Salud, Junta de Andalucia
   (07/43, PI 0193/09 to JL-M, PI-0252/2009 to JD-L and PI-0058-2010 to
   PP-M). Also supported by Centro de Excelencia Investigadora en Aceite de
   Oliva y Salud (CEAS) and FEDER, Fondo Social Europeo. AG-R is supported
   by a research contract of ISCIII (Programa Rio-Hortega).
CR Agudo A, 2007, AM J CLIN NUTR, V85, P1634, DOI 10.1093/ajcn/85.6.1634
   Anderson RA, 2001, ATHEROSCLEROSIS, V154, P475, DOI 10.1016/S0021-9150(00)00499-8
   Azadbakht L, 2005, DIABETES CARE, V28, P2823, DOI 10.2337/diacare.28.12.2823
   Babio N, 2009, NUTR METAB CARDIOVAS, V19, P563, DOI 10.1016/j.numecd.2008.10.007
   Bae JH, 2003, INT J CARDIOL, V87, P259, DOI 10.1016/S0167-5273(02)00347-9
   Bellido C, 2004, AM J CLIN NUTR, V80, P1487, DOI 10.1093/ajcn/80.6.1487
   Bellido C, 2006, NUTR METAB CARDIOVAS, V16, P524, DOI 10.1016/j.numecd.2005.09.007
   Berry SEE, 2008, J NUTR, V138, P1910, DOI 10.1093/jn/138.10.1910
   Bes-Rastrollo M, 2006, LIPIDS, V41, P249, DOI 10.1007/s11745-006-5094-6
   BEUNZA ETJ, 2010, AM J CLIN NUTR
   Brunelleschi S, 2007, PHARMACOL RES, V56, P542, DOI 10.1016/j.phrs.2007.10.001
   Camargo A, 2010, BMC GENOMICS, V11, DOI 10.1186/1471-2164-11-253
   Cardona F, 2008, EUR J CLIN INVEST, V38, P510, DOI 10.1111/j.1365-2362.2008.01959.x
   Carluccio MA, 1999, ARTERIOSCL THROM VAS, V19, P220, DOI 10.1161/01.ATV.19.2.220
   Chrysohoou C, 2004, J AM COLL CARDIOL, V44, P152, DOI 10.1016/j.jacc.2004.03.039
   Cypess AM, 2009, NEW ENGL J MED, V360, P1509, DOI 10.1056/NEJMoa0810780
   Dai J, 2008, CIRCULATION, V117, P169, DOI 10.1161/CIRCULATIONAHA.107.710699
   Devaraj S, 2008, METABOLISM, V57, P867, DOI 10.1016/j.metabol.2008.02.016
   Esmaillzadeh A, 2007, AM J CLIN NUTR, V85, P910, DOI 10.1093/ajcn/85.3.910
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   Esposito K, 2006, PUBLIC HEALTH NUTR, V9, P1073, DOI 10.1017/S1368980007668529
   Estruch R, 2006, ANN INTERN MED, V145, P1, DOI 10.7326/0003-4819-145-1-200607040-00004
   Fitó M, 2007, ARCH INTERN MED, V167, P1195, DOI 10.1001/archinte.167.11.1195
   Fuentes F, 2008, BRIT J NUTR, V100, P159, DOI 10.1017/S0007114508888708
   Fuentes F, 2001, ANN INTERN MED, V134, P1115, DOI 10.7326/0003-4819-134-12-200106190-00011
   Futterman LG, 2002, AM J CRIT CARE, V11, P482, DOI 10.4037/ajcc2002.11.5.482
   Garg A, 1998, AM J CLIN NUTR, V67, p577S, DOI 10.1093/ajcn/67.3.577S
   Ghanim H, 2004, CIRCULATION, V110, P1564, DOI 10.1161/01.CIR.0000142055.53122.FA
   Ghosh S, 1998, ANNU REV IMMUNOL, V16, P225, DOI 10.1146/annurev.immunol.16.1.225
   Giugliano D, 2008, CURR OPIN LIPIDOL, V19, P63, DOI 10.1097/MOL.0b013e3282f2fa4d
   Goode GK, 1997, CIRCULATION, V96, P2802, DOI 10.1161/01.CIR.96.9.2802
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Halton TL, 2006, NEW ENGL J MED, V355, P1991, DOI 10.1056/NEJMoa055317
   Hao JJ, 2010, J NUTR BIOCHEM, V21, P634, DOI 10.1016/j.jnutbio.2009.03.012
   Hennig B, 2000, METABOLISM, V49, P1006, DOI 10.1053/meta.2000.7736
   Howard BV, 2006, JAMA-J AM MED ASSOC, V295, P655, DOI 10.1001/jama.295.6.655
   Hu FB, 2002, CURR OPIN LIPIDOL, V13, P3, DOI 10.1097/00041433-200202000-00002
   Jellema A, 2004, EUR J CLIN INVEST, V34, P766, DOI 10.1111/j.1365-2362.2004.01414.x
   Jiménez-Gómez Y, 2010, J NUTR, V140, P1595, DOI 10.3945/jn.109.120816
   Jimenez-Gomez Yolanda, 2009, Atherosclerosis, V204, pe70, DOI 10.1016/j.atherosclerosis.2008.09.011
   Khymenets O, 2009, OMICS, V13, P7, DOI 10.1089/omi.2008.0079
   Kishimoto T, 2005, ANNU REV IMMUNOL, V23, P1, DOI 10.1146/annurev.immunol.23.021704.115806
   Konstantinidou V, 2010, FASEB J, V24, P2546, DOI 10.1096/fj.09-148452
   Kris-Etherton PM, 1999, CIRCULATION, V100, P1253, DOI 10.1161/01.CIR.100.11.1253
   Llorente-Cortés V, 2010, ATHEROSCLEROSIS, V208, P442, DOI 10.1016/j.atherosclerosis.2009.08.004
   López S, 2008, AM J CLIN NUTR, V88, P638, DOI 10.1093/ajcn/88.3.638
   López-Miranda J, 2010, NUTR METAB CARDIOVAS, V20, P284, DOI 10.1016/j.numecd.2009.12.007
   Lopez-Miranda J, 2007, MOL NUTR FOOD RES, V51, P1249, DOI 10.1002/mnfr.200600307
   Lutsey PL, 2008, CIRCULATION, V117, P754, DOI 10.1161/CIRCULATIONAHA.107.716159
   Mantena SK, 2006, FREE RADICAL BIO MED, V40, P1603, DOI 10.1016/j.freeradbiomed.2005.12.032
   Martínez-González MA, 2008, BMJ-BRIT MED J, V336, P1348, DOI 10.1136/bmj.39561.501007.BE
   Mata P, 1996, ARTERIOSCL THROM VAS, V16, P1347, DOI 10.1161/01.ATV.16.11.1347
   McManus K, 2001, INT J OBESITY, V25, P1503, DOI 10.1038/sj.ijo.0801796
   Mendez MA, 2006, J NUTR, V136, P2934, DOI 10.1093/jn/136.11.2934
   Mozaffarian D, 2007, LANCET, V370, P667, DOI 10.1016/S0140-6736(07)61343-9
   Núñez-Córdoba JM, 2009, AM J EPIDEMIOL, V169, P339, DOI 10.1093/aje/kwn335
   Orchard TJ, 2005, ANN INTERN MED, V142, P611, DOI 10.7326/0003-4819-142-8-200504190-00009
   Panagiotakos D, 2009, NUTR METAB CARDIOVAS, V19, P253, DOI 10.1016/j.numecd.2008.06.005
   Panagiotakos DB, 2004, AM HEART J, V147, P106, DOI 10.1016/S0002-8703(03)00442-3
   Panagiotakos DB, 2006, NUTRITION, V22, P449, DOI 10.1016/j.nut.2005.11.004
   Panagiotakos DB, 2009, INT J EPIDEMIOL, V38, P856, DOI 10.1093/ije/dyp142
   Paniagua JA, 2007, DIABETES CARE, V30, P1717, DOI 10.2337/dc06-2220
   Paniagua JA, 2007, J AM COLL NUTR, V26, P434, DOI 10.1080/07315724.2007.10719633
   Pereira MA, 2005, LANCET, V365, P36, DOI 10.1016/S0140-6736(04)17663-0
   Pérez-Jiménez F, 1999, ATHEROSCLEROSIS, V145, P351, DOI 10.1016/S0021-9150(99)00116-1
   Perez-Jimenez F, 2005, EUR J CLIN INVEST, V35, P421, DOI 10.1111/j.1365-2362.2005.01516.x
   Pérez-Jiménez F, 2006, PUBLIC HEALTH NUTR, V9, P1083, DOI 10.1017/S1368980007668566
   Pérez-Jiménez F, 2007, MOL NUTR FOOD RES, V51, P1199, DOI [10.1002/mnfr.200600273, 10.1002/mnfr.200790023]
   Perez-Martinez P, 2007, ATHEROSCLEROSIS, V194, pE141, DOI 10.1016/j.atherosclerosis.2006.11.033
   Perez-Martinez P, 2010, CLIN SCI, V119, P251, DOI 10.1042/CS20100015
   Perez-Martinez P, 2010, ATHEROSCLEROSIS, V209, P533, DOI 10.1016/j.atherosclerosis.2009.09.023
   Phillips C, 2006, CURR OPIN CARDIOL, V21, P185, DOI 10.1097/01.hco.0000221579.25878.11
   Piva R, 2006, ANTIOXID REDOX SIGN, V8, P478, DOI 10.1089/ars.2006.8.478
   Psaltopoulou T, 2004, AM J CLIN NUTR, V80, P1012, DOI 10.1093/ajcn/80.4.1012
   Rallidis LS, 2009, AM J CLIN NUTR, V90, P263, DOI 10.3945/ajcn.2008.27290
   Razquin C, 2009, EUR J CLIN NUTR, V63, P1387, DOI 10.1038/ejcn.2009.106
   Riccardi G, 2004, CLIN NUTR, V23, P447, DOI 10.1016/j.clnu.2004.02.006
   Rodríguez VM, 2002, AM J CLIN NUTR, V75, P213, DOI 10.1093/ajcn/75.2.213
   Rojo-Martínez G, 2006, EUR J CLIN NUTR, V60, P1195, DOI 10.1038/sj.ejcn.1602437
   Romaguera D, 2010, AM J CLIN NUTR, V92, P912, DOI 10.3945/ajcn.2010.29482
   Romaguera D, 2009, J NUTR, V139, P1728, DOI 10.3945/jn.109.108902
   Ros E, 2003, AM J CLIN NUTR, V78, p617S, DOI 10.1093/ajcn/78.3.617S
   Ruano J, 2005, J AM COLL CARDIOL, V46, P1864, DOI 10.1016/j.jacc.2005.06.078
   Ruano J, 2007, AM J CLIN NUTR, V86, P341, DOI 10.1093/ajcn/86.2.341
   Salas-Salvadó J, 2008, ARCH INTERN MED, V168, P2449, DOI 10.1001/archinte.168.22.2449
   Sánchez-Tainta A, 2008, EUR J CARDIOV PREV R, V15, P589, DOI 10.1097/HJR.0b013e328308ba61
   Schröder H, 2004, J NUTR, V134, P3355, DOI 10.1093/jn/134.12.3355
   Schwartz GJ, 2008, CELL METAB, V8, P281, DOI 10.1016/j.cmet.2008.08.005
   Sofi F, 2008, BMJ-BRIT MED J, V337, DOI 10.1136/bmj.a1344
   Sofi F, 2008, BRIT MED J, V337, DOI 10.1136/bmj.a346
   Soriguer F, 2009, EUR J CLIN NUTR, V63, P1371, DOI 10.1038/ejcn.2009.65
   Tinker LF, 2008, ARCH INTERN MED, V168, P1500, DOI 10.1001/archinte.168.14.1500
   Tortosa A, 2007, DIABETES CARE, V30, P2957, DOI 10.2337/dc07-1231
   Trichopoulou A, 2005, AM J CLIN NUTR, V82, P935, DOI 10.1093/ajcn/82.5.935
   Trichopoulou A, 2005, ARCH INTERN MED, V165, P929, DOI 10.1001/archinte.165.8.929
   TRICHOPOULOU A, 1995, BMJ-BRIT MED J, V311, P1457, DOI 10.1136/bmj.311.7018.1457
   Trichopoulou A, 2005, BMJ-BRIT MED J, V330, P991, DOI 10.1136/bmj.38415.644155.8F
   Trichopoulou A, 2003, NEW ENGL J MED, V348, P2599, DOI 10.1056/NEJMoa025039
   Tzanavari T, 2010, CURR DIR AUTOIMMUN, V11, P145, DOI 10.1159/000289203
   Ursini F, 1998, FREE RADICAL BIO MED, V25, P250, DOI 10.1016/S0891-5849(98)00044-6
   Wilson-Fritch L, 2004, J CLIN INVEST, V114, P1281, DOI 10.1172/JCI200421752
NR 101
TC 140
Z9 153
U1 2
U2 71
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD MAR
PY 2011
VL 17
IS 8
BP 769
EP 777
DI 10.2174/138161211795428948
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 768PS
UT WOS:000290948400003
PM 21443484
DA 2025-06-11
ER

PT J
AU Shelton, RC
   Papakostas, GI
AF Shelton, Richard C.
   Papakostas, George I.
TI Augmentation of antidepressants with atypical antipsychotics for
   treatment-resistant major depressive disorder
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE major depressive disorder; antidepressants; atypical antipsychotics;
   treatment resistant; augmentation
ID SEROTONIN REUPTAKE INHIBITORS; STAR-ASTERISK-D; DOUBLE-BLIND;
   OLANZAPINE/FLUOXETINE COMBINATION; ARIPIPRAZOLE AUGMENTATION;
   RISPERIDONE AUGMENTATION; DOPAMINERGIC-NEURONS; OPEN-LABEL; ZIPRASIDONE;
   OLANZAPINE
AB Objective: Atypical antipsychotics (AAPs) have been hypothesized to be beneficial in treatment-resistant depression (TRD). This paper will review a biochemical rationale and will summarize the data regarding the effectiveness of AAPs in TRD.
   Method: Studies were identified using searches of Pubmed/Medline, EMBase and the Cochrane databases by cross-referencing the term 'depression' with each of the six AAPs.
   Results: After initial positive, short case reports and clinical trials, larger studies failed to show the effectiveness of AAPs combined with antidepressants for TRD. More recently, larger scale clinical trials have supported the effectiveness of at least some of these medications. While AAPs have gained in popularity for TRD, there are nagging concerns regarding risks such as metabolic syndrome and tardive dyskinesia.
   Conclusion: The existing research provides some support for the beneficial effects of AAPs when combined with SSRI's in TRD. These medications pose significant risks that must be considered in their use.
C1 [Shelton, Richard C.] Vanderbilt Univ, Sch Med, Dept Psychiat, Nashville, TN 37212 USA.
   [Papakostas, George I.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Psychiat, Boston, MA USA.
C3 Vanderbilt University; Harvard University; Harvard Medical School;
   Harvard University Medical Affiliates; Massachusetts General Hospital
RP Shelton, RC (corresponding author), 1500 21st Ave S,Suite 2200, Nashville, TN 37212 USA.
EM richard.shelton@vanderbilt.edu
RI Shelton, Richard/AAC-4137-2022; Papakostas, George/I-6905-2013
FU NIMH NIH HHS [K23 MH069629, K24 MH01741] Funding Source: Medline
CR Barbee James G, 2004, Ann Clin Psychiatry, V16, P189, DOI 10.1080/10401230490521954
   Barbee JG, 2004, J CLIN PSYCHIAT, V65, P975
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   Blier P, 2005, J CLIN PSYCHIAT, V66, P30
   Bymaster FP, 1996, PSYCHOPHARMACOLOGY, V124, P87, DOI 10.1007/BF02245608
   Bymaster FP, 1996, NEUROPSYCHOPHARMACOL, V14, P87, DOI 10.1016/0893-133X(94)00129-N
   Calabrese JR, 2005, AM J PSYCHIAT, V162, P1351, DOI 10.1176/appi.ajp.162.7.1351
   Corya SA, 2006, DEPRESS ANXIETY, V23, P364, DOI 10.1002/da.20130
   Di Mascio M, 1998, BRAIN RES BULL, V46, P547, DOI 10.1016/S0361-9230(98)00054-9
   DiMascio M, 1997, NEUROSCIENCE, V79, P957
   Dunner DL, 2007, J CLIN PSYCHIAT, V68, P1071, DOI 10.4088/JCP.v68n0714
   Fava M, 2003, PSYCHIAT CLIN N AM, V26, P457, DOI 10.1016/S0193-953X(02)00107-7
   FRANK E, 1991, ARCH GEN PSYCHIAT, V48, P851, DOI 10.1001/archpsyc.1991.01810330075011
   Gharabawi G, 2006, INT J NEUROPSYCHOPH, V9, pS236
   Gobert A, 2000, SYNAPSE, V36, P205, DOI 10.1002/(SICI)1098-2396(20000601)36:3<205::AID-SYN5>3.0.CO;2-D
   Goff DC, 1998, J CLIN PSYCHOPHARM, V18, P296, DOI 10.1097/00004714-199808000-00009
   Haddad PM, 2004, DRUGS, V64, P2291, DOI 10.2165/00003495-200464200-00003
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Hellerstein DJ, 2004, PROG NEURO-PSYCHOPH, V28, P1347, DOI 10.1016/j.pnpbp.2004.06.016
   Ichikawa J, 1999, J PHARMACOL EXP THER, V291, P1227
   ICHIKAWA J, 2002, J NEUROCHEM, V1, P2
   Keck PE, 2000, J CLIN PSYCHIAT, V61, P33
   KEITNER GI, 2006, 159 ANN M AM PSYCH A
   Khullar A, 2006, 159 ANN M AM PSYCH A
   LIEGEOIS JF, 2002, BRAIN RES, V30, P947
   Mattingly G, 2006, 159 ANN M AM PSYCH A
   MCINTYRE A, 2006, QUETIAPINE REDUCES R
   MELTZER HY, 1991, SCHIZOPHRENIA BULL, V17, P263, DOI 10.1093/schbul/17.2.263
   MELTZER HY, 1989, EUR ARCH PSY CLIN N, V238, P332, DOI 10.1007/BF00449814
   MELTZER HY, 2003, BIOL PSYCHIAT, V27, P1159, DOI DOI 10.1016/J.PNPBP.2003.09.010
   Miller IW, 1998, J CLIN PSYCHIAT, V59, P608, DOI 10.4088/JCP.v59n1108
   Ostroff RB, 1999, J CLIN PSYCHIAT, V60, P256, DOI 10.4088/JCP.v60n0410
   Papakostas GI, 2005, J CLIN PSYCHIAT, V66, P1326, DOI 10.4088/JCP.v66n1017
   Papakostas GI, 2004, J CLIN PSYCHIAT, V65, P217
   Rapaport MH, 2006, NEUROPSYCHOPHARMACOL, V31, P2505, DOI 10.1038/sj.npp.1301113
   REFERENCE R, 2003, BIOL PSYCHIAT, V54, P573
   Rush AJ, 2006, AM J PSYCHIAT, V163, P1905, DOI 10.1176/appi.ajp.163.11.1905
   Schmidt AW, 2001, EUR J PHARMACOL, V425, P197, DOI 10.1016/S0014-2999(01)01188-8
   Shelton RC, 1999, J CLIN PSYCHIAT, V60, P57
   Shelton RC, 2005, J CLIN PSYCHIAT, V66, P1289, DOI 10.4088/JCP.v66n1012
   Simon JS, 2005, J CLIN PSYCHIAT, V66, P1216, DOI 10.4088/JCP.v66n1002
   Tarazi FI, 2003, J PHARMACOL EXP THER, V306, P1145, DOI 10.1124/jpet.103.052597
   Thase ME, 2007, J CLIN PSYCHIAT, V68, P224, DOI 10.4088/JCP.v68n0207
   Tollefson GD, 1999, BRIT J PSYCHIAT, V174, P30, DOI 10.1192/S0007125000293641
   TOLLEFSON GD, 1999, SCHIZOPHR RES S, V35, P26
   Trivedi MH, 2006, AM J PSYCHIAT, V163, P28, DOI 10.1176/appi.ajp.163.1.28
   Weisstaub NV, 2006, SCIENCE, V313, P536, DOI 10.1126/science.1123432
   Worthington JJ, 2005, INT CLIN PSYCHOPHARM, V20, P9, DOI 10.1097/00004850-200501000-00002
   ZUNG WWK, 1965, ARCH GEN PSYCHIAT, V12, P63, DOI 10.1001/archpsyc.1965.01720310065008
NR 49
TC 87
Z9 92
U1 1
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
EI 1600-0447
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD APR
PY 2008
VL 117
IS 4
BP 253
EP 259
DI 10.1111/j.1600-0447.2007.01130.x
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 270YV
UT WOS:000253757000003
PM 18190674
DA 2025-06-11
ER

PT J
AU Yang, HB
   Chen, MP
   Liu, SS
   Zhang, YL
   Wang, LJ
   Duan, L
   Gong, FY
   Zhu, HJ
   Pan, H
AF Yang, Hongbo
   Chen, Meiping
   Liu, Shanshan
   Zhang, Yuelun
   Wang, Linjie
   Duan, Lian
   Gong, Fengying
   Zhu, Huijuan
   Pan, Hui
TI Association Between the Serum Level of Asprosin and Metabolic Parameters
   in Adult Growth Hormone Deficiency: A Cross-Sectional Study
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
DE adult growth hormone deficiency; asprosin; metabolic syndrome
ID CARDIOVASCULAR RISK; REPLACEMENT THERAPY; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; BODY-COMPOSITION; GH TREATMENT; GLUCOSE; ADIPONECTIN;
   PROFILE; STRESS
AB Objective: Adult growth hormone deficiency (AGHD) is characterized by central adiposity and metabolic disorders. Asprosin, a newly discovered adipokine, plays a crucial role in connecting adipose tissue function with the development of metabolic syndrome. This study aims to evaluate the circulating levels of asprosin in AGHD patients and explore the potential correlation between asprosin levels and various metabolic parameters.Subjects and Methods: Forty male patients with AGHD (mean age: 33.5 +/- 9.5 yrs and mean BMI: 25.0 +/- 4.5 kg/m2) and forty age-, gender-, and BMI-matched non-AGHD controls were enrolled. Medical history, anthropometric parameters (weight, height, waist circumference), and biochemical and hormonal investigations were collected from the electronic medical record system. Fat mass, fat percentage, and fat-free mass (FFM) were evaluated by bioelectrical impedance. Serum levels of asprosin were measured by ELISA.Results: Patients with AGHD demonstrated notably increased waist-to-hip ratios, triglyceride levels, and decreased HDL-cholesterol levels compared with the control group. In additionally, AGHD patients exhibited significantly higher serum levels of asprosin compared with controls (p=0.039). A notable association was observed between serum asprosin levels and FFM, triglycerides, and HDL-cholesterol levels in the whole population.Conclusions: Our study highlights distinct metabolic alterations in AGHD patients when matched for BMI with controls and investigates variations in serum asprosin levels for the first time. These findings have significant implications for identifying potential biomarkers for metabolic syndrome risk in AGHD patients and informing future treatment approaches.
C1 [Yang, Hongbo; Chen, Meiping; Liu, Shanshan; Wang, Linjie; Duan, Lian; Gong, Fengying; Zhu, Huijuan; Pan, Hui] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Endocrinol, Key Lab Endocrinol Natl Hlth Commiss,State Key Lab, 1 Shuaifuyuan, Beijing, Peoples R China.
   [Zhang, Yuelun] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Med Res Ctr, 1 Shuaifuyuan, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital; Peking Union Medical College;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital
RP Zhu, HJ; Pan, H (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Endocrinol, Key Lab Endocrinol Natl Hlth Commiss,State Key Lab, 1 Shuaifuyuan, Beijing, Peoples R China.
EM yanghb@pumch.cn; 13512887609@163.com; liuss320@163.com;
   yuelunzhang@outlook.com; eileenwood@163.com; duanlianpumc@163.com;
   fygong@sina.com; shengxin2004@163.com; panhui@pumch.cn
RI Zhang, Yuelun/HHN-8411-2022
OI Zhang, Yuelun/0000-0001-7990-9003; , hongbo/0000-0003-2985-8265; Zhu,
   Huijuan/0000-0001-5172-6870
FU National Natural Science Foundation of China [81970678]; National High
   Level Hospital Clinical Research Funding [2022-PUMCH-A-249]; CAMS
   Innovation Fund for Medical Sciences [CIFMS 2021-I2M-1-003]
FX This work was supported by the National Natural Science Foundation of
   China (no. 81970678); National High Level <EM><STRONG>
   </STRONG></EM>Hospital Clinical Research Funding (2022-PUMCH-A-249); and
   CAMS Innovation Fund for Medical Sciences (CIFMS 2021-I2M-1-003).
CR Al-Samerria S, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24119556
   Al-Samerria S, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10102664
   Basile U, 2018, BIOFACTORS, V44, P480, DOI 10.1002/biof.1444
   Currò D, 2020, BIOFACTORS, V46, P629, DOI 10.1002/biof.1628
   Di Somma C, 2017, BEST PRACT RES CL EN, V31, P25, DOI 10.1016/j.beem.2017.03.005
   Doycheva I, 2022, HEPATOL COMMUN, V6, P2227, DOI 10.1002/hep4.1953
   Duerrschmid C, 2017, NAT MED, V23, P1444, DOI 10.1038/nm.4432
   Farrag M, 2023, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.1101091
   Feng B, 2023, SCI ADV, V9, DOI 10.1126/sciadv.abq6718
   Fisker S, 1997, METABOLISM, V46, P812, DOI 10.1016/S0026-0495(97)90128-1
   Friedrich N, 2012, DIABETES CARE, V35, P768, DOI 10.2337/dc11-1833
   Fukuda I, 2004, GROWTH HORM IGF RES, V14, P449, DOI 10.1016/j.ghir.2004.06.005
   Gazzaruso C, 2014, J CLIN ENDOCR METAB, V99, P18, DOI 10.1210/jc.2013-2394
   Giovannini L, 2015, ENDOCR J, V62, P1037, DOI 10.1507/endocrj.EJ15-0337
   Götherström G, 2001, J CLIN ENDOCR METAB, V86, P4657, DOI 10.1210/jc.86.10.4657
   Hong T, 2021, INT J ENDOCRINOL, V2021, DOI 10.1155/2021/6622129
   Huang ZX, 2020, TRENDS ENDOCRIN MET, V31, P642, DOI 10.1016/j.tem.2020.04.005
   Joaquin C, 2008, EUR J ENDOCRINOL, V158, P483, DOI 10.1530/EJE-07-0554
   Jung TW, 2019, J CELL PHYSIOL, V234, P20888, DOI 10.1002/jcp.28694
   Ke XA, 2020, INT J ENDOCRINOL, V2020, DOI 10.1155/2020/8855996
   Li EW, 2019, CELL METAB, V30, P319, DOI 10.1016/j.cmet.2019.05.022
   Luger A, 2012, DIABETES CARE, V35, P57, DOI 10.2337/dc11-0449
   Maison P, 2004, J CLIN ENDOCR METAB, V89, P2192, DOI 10.1210/jc.2003-030840
   Mancini A, 2018, ENDOCRINE, V59, P130, DOI 10.1007/s12020-017-1468-1
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mechanick JI, 2016, J AM COLL CARDIOL, V68, P1785, DOI 10.1016/j.jacc.2016.06.072
   Melmed S, 2019, NEW ENGL J MED, V380, P2551, DOI 10.1056/NEJMra1817346
   Mirr M, 2023, BIOMEDICINES, V11, DOI 10.3390/biomedicines11061568
   Molitch ME, 2011, J CLIN ENDOCR METAB, V96, P1587, DOI 10.1210/jc.2011-0179
   Molitch ME, 2006, J CLIN ENDOCR METAB, V91, P1621, DOI 10.1210/jc.2005-2227
   Moller N, 2009, ENDOCR REV, V30, P152, DOI 10.1210/er.2008-0027
   Nor NSM, 2016, PEDIATR DIABETES, V17, P458, DOI 10.1111/pedi.12303
   Orrù S, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18102145
   Romere C, 2016, CELL, V165, P566, DOI 10.1016/j.cell.2016.02.063
   Ugur K, 2022, EUR REV MED PHARMACO, V26, P2124, DOI 10.26355/eurrev_202203_28360
   Unamuno X, 2018, EUR J CLIN INVEST, V48, DOI 10.1111/eci.12997
   Vergani E, 2023, J ENDOCRINOL INVEST, V46, P1187, DOI 10.1007/s40618-022-01974-5
   Wang YT, 2019, ENDOCR PRACT, V25, P446, DOI 10.4158/EP-2018-0541
   Wiecek M, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01782
   Witkowska-Sedek E, 2018, ACTA BIOCHIM POL, V65, P333, DOI 10.18388/abp.2018_2601
   Zhang L, 2019, CLIN CHIM ACTA, V489, P183, DOI 10.1016/j.cca.2017.10.034
   Zhong M, 2023, BMC ENDOCR DISORD, V23, DOI 10.1186/s12902-023-01311-8
   Zhu HJ, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0185561
   Zou J, 2022, J TRANSL MED, V20, DOI 10.1186/s12967-022-03542-0
NR 44
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PD NOV 19
PY 2024
VL 2024
AR 9735508
DI 10.1155/ije/9735508
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA N9G5I
UT WOS:001367335800001
PM 39610397
OA gold
DA 2025-06-11
ER

PT J
AU Nikolic, M
   Lazarevic, N
   Novakovic, J
   Jeremic, N
   Jakovljevic, V
   Zivkovic, V
   Bradic, J
   Pecarski, D
   Tel-Çayan, G
   Glamocija, J
   Sokovic, M
   Gregori, A
   Petrovic, J
AF Nikolic, Marina
   Lazarevic, Nevena
   Novakovic, Jovana
   Jeremic, Nevena
   Jakovljevic, Vladimir
   Zivkovic, Vladimir
   Bradic, Jovana
   Pecarski, Danijela
   Tel-Cayan, Gulsen
   Glamocija, Jasmina
   Sokovic, Marina
   Gregori, Andrej
   Petrovic, Jovana
TI Characterization, In Vitro Biological Activity and In Vivo
   Cardioprotective Properties of Trametes versicolor (L.:Fr.) Quel.
   Heteropolysaccharides in a Rat Model of Metabolic Syndrome
SO PHARMACEUTICALS
LA English
DT Article
DE Trametes versicolor; heteropolysaccharides; antioxidant; antimicrobial
   agent; metabolic syndrome; rat heart; cardioprotection
ID TAIL MEDICINAL MUSHROOM; CORIOLUS-VERSICOLOR; ANTITUMOR-ACTIVITY;
   GANODERMA-LUCIDUM; FRUITING BODIES; POLYSACCHARIDES; PURIFICATION;
   ELUCIDATION; INHIBITION
AB The present study aimed to examine the biological activity and cardioprotective potential of Trametes versicolor heteropolysaccharides (TVH) in a rat model of metabolic syndrome (MetS). This study included 40 Wistar rats divided into 5 groups: CTRL-healthy non-treated rats; MetS-non-treated rats; and H-TV, M-TV and L-TV-rats with MetS treated with either 300, 200 or 100 mg/kg TVH per os for 4 weeks. After finishing the treatment, we conducted an oral glucose tolerance test (OGTT), hemodynamic measurements and the animals were sacrificed, hearts isolated and subjected to the Langendorff technique. Blood samples were used for the determination of oxidative stress parameters, lipid status and insulin levels. We showed that & alpha;-amylase inhibition was not the mode of TVH antidiabetic action, while TVH showed a moderate inhibition of pathogenic microorganisms' growth (MIC 8.00 mg & BULL;mL(-1); MBC/MFC 16.00 mg & BULL;mL(-1)). H-TV and M-TV significantly reduced the level of prooxidants (O-2(-), H2O2, TBARS; p < 0.05), increased antioxidants activity (SOD, CAT, GSH; p < 0.05), reduced blood pressure (p < 0.05), improved glucose homeostasis in the OGTT test (p < 0.05), and ejection fraction (p < 0.05) and cardiac contractility (p < 0.05) compared to MetS (p < 0.05). Moreover, TVH treatment normalized the lipid status and decreased insulin levels compared to MetS rats (p < 0.05). The obtained results demonstrated that the TVH may be considered a useful agent for cardioprotection in MetS conditions.
C1 [Nikolic, Marina; Jakovljevic, Vladimir; Zivkovic, Vladimir] Univ Kragujevac, Fac Med Sci, Dept Physiol, Svetozara Markov 69, Kragujevac 34000, Serbia.
   [Nikolic, Marina; Lazarevic, Nevena; Novakovic, Jovana; Jeremic, Nevena; Jakovljevic, Vladimir; Zivkovic, Vladimir; Bradic, Jovana] Ctr Excellence Redox Balance Res Cardiovasc & Meta, Kragujevac 34000, Serbia.
   [Lazarevic, Nevena; Novakovic, Jovana; Jeremic, Nevena; Bradic, Jovana] Univ Kragujevac, Fac Med Sci, Dept Pharm, Svetozara Markov 69, Kragujevac 34000, Serbia.
   [Lazarevic, Nevena; Jakovljevic, Vladimir] IM Sechenov First Moscow State Med Univ, Dept Human Pathol, Moscow 119146, Russia.
   [Jeremic, Nevena] IM Sechenov First Moscow State Med Univ, Moscow 119991, Russia.
   [Zivkovic, Vladimir] IM Sechenov First Moscow State Med Univ, Inst Biodesign & Complex Syst Modelling, Dept Pharmacol, Moscow 119146, Russia.
   [Pecarski, Danijela] Acad Appl Studies Belgrade, Coll Hlth Sci, Belgrade 11000, Serbia.
   [Tel-Cayan, Gulsen] Mugla Sitki Kocman Univ, Mugla Vocat Sch, Dept Chem & Chem Proc Technol, TR-48000 Mugla, Turkiye.
   [Glamocija, Jasmina; Sokovic, Marina; Petrovic, Jovana] Univ Belgrade, Inst Biol Res Sinisa Stankovic, Natl Inst Republ Serbia, Bulevar Despota Stefana 142, Belgrade 11000, Serbia.
   [Gregori, Andrej] MycoMedica Ltd, Podkoren 72, Kranjska Gora 4280, Slovenia.
C3 University of Kragujevac; University of Kragujevac; Sechenov First
   Moscow State Medical University; Sechenov First Moscow State Medical
   University; Sechenov First Moscow State Medical University; Ministry of
   National Education - Turkey; Mugla Sitki Kocman University; University
   of Belgrade
RP Lazarevic, N (corresponding author), Ctr Excellence Redox Balance Res Cardiovasc & Meta, Kragujevac 34000, Serbia.; Lazarevic, N (corresponding author), Univ Kragujevac, Fac Med Sci, Dept Pharm, Svetozara Markov 69, Kragujevac 34000, Serbia.; Lazarevic, N (corresponding author), IM Sechenov First Moscow State Med Univ, Dept Human Pathol, Moscow 119146, Russia.; Petrovic, J (corresponding author), Univ Belgrade, Inst Biol Res Sinisa Stankovic, Natl Inst Republ Serbia, Bulevar Despota Stefana 142, Belgrade 11000, Serbia.
EM marina.rankovic.95@gmail.com; nevenasdraginic@gmail.com;
   jovana.jeremic@medf.kg.ac.rs; nbarudzic@hotmail.com;
   drvladakgbg@yahoo.com; vladimirziv@gmail.com; jovanabradickg@gmail.com;
   danijela.pecarski@assb.edu.rs; gulsentel@mu.edu.tr;
   jasna@ibiss.bg.ac.rs; marina.sokovic@nitra.gov.rs;
   andrej.gregori@zanaravo.com; jovana0303@ibiss.bg.ac.rs
RI Jeremic, Nevena/U-9443-2019; Zivkovic, Vladimir/AAP-6213-2020; Bradic,
   Jovana/ABH-9126-2020; Petrović, Jovana/ADM-7692-2022; Tel-Çayan,
   Gülsen/AAG-4351-2019; Glamoclija, Jasmina/JNS-9762-2023; Jakovljevic,
   Vladimir/V-1583-2019
OI Bradic, Jovana/0000-0001-5388-6085; Novakovic,
   Jovana/0000-0002-8084-3264; Nikolic, Marina/0000-0001-7829-5812;
   Draginic, Nevena/0000-0002-5386-8116; Glamoclija,
   Jasmina/0000-0001-6823-1137; Tel-Cayan, Gulsen/0000-0002-1916-7391;
   Petrovic, Jovana/0000-0002-9016-9971
FU Ministry of Science, Technological Development and Innovation, Republic
   of Serbia [451-03-47/2023-01/200007, 451-03-47/2023-01/200111]
FX The research was supported by the Ministry of Science, Technological
   Development and Innovation, Republic of Serbia through Grant Agreements
   with University of Belgrade-Institute for Biological Research Sinisa
   Stankovic; National Institute of Republic of Serbia No.
   451-03-47/2023-01/200007, and with University of Kragujevac-Faculty of
   Medical Sciences No. 451-03-47/2023-01/200111.
CR Abdel-Hamid Heba A, 2019, Endocr Regul, V53, P26, DOI 10.2478/enr-2019-0004
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Amirullah NA, 2018, FOOD RES INT, V105, P517, DOI 10.1016/j.foodres.2017.11.023
   Angelova G, 2022, J FUNGI, V8, DOI 10.3390/jof8070738
   Jovanovic JA, 2021, J FUNGI, V7, DOI 10.3390/jof7010058
   Bains A, 2021, MATERIALS, V14, DOI 10.3390/ma14247640
   Bains A, 2020, 3 BIOTECH, V10, DOI 10.1007/s13205-020-02397-w
   Chan SW, 2021, PHARM BIOL, V59, P1161, DOI 10.1080/13880209.2021.1969413
   Chay WY, 2017, J ALTERN COMPLEM MED, V23, P648, DOI 10.1089/acm.2016.0136
   Chen CH, 2015, J AGR FOOD CHEM, V63, P9232, DOI 10.1021/acs.jafc.5b02668
   Cui J, 2007, J IND MICROBIOL BIOT, V34, P393, DOI 10.1007/s10295-007-0209-5
   Deveci E, 2019, J FOOD BIOCHEM, V43, DOI 10.1111/jfbc.12965
   Dordevski N, 2023, PHARMACEUTICALS-BASE, V16, DOI 10.3390/ph16010021
   Draginic ND, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/1344946
   Gao Yihuai, 2004, International Journal of Medicinal Mushrooms, V6, P327
   Habtemariam S, 2020, BIOMEDICINES, V8, DOI 10.3390/biomedicines8050135
   Hossen SMM, 2021, SAUDI J BIOL SCI, V28, P6375, DOI 10.1016/j.sjbs.2021.07.016
   Hsu WK, 2013, CARBOHYD POLYM, V92, P297, DOI 10.1016/j.carbpol.2012.10.001
   Huang ZF, 2020, CURR MICROBIOL, V77, P3526, DOI 10.1007/s00284-020-02156-3
   Jakovljevic V, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20010006
   Janjusevic L, 2018, NAT PROD RES, V32, P963, DOI 10.1080/14786419.2017.1366484
   Janjusevic L, 2017, J ENZYM INHIB MED CH, V32, P355, DOI 10.1080/14756366.2016.1252759
   Jeff IB, 2013, FITOTERAPIA, V84, P338, DOI 10.1016/j.fitote.2012.12.008
   Jeremic J, 2018, CLIN EXP PHARMACOL P, V45, P683, DOI 10.1111/1440-1681.12930
   Jeremic JN, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21239100
   Jeremic JN, 2019, MOL CELL BIOCHEM, V460, P151, DOI 10.1007/s11010-019-03577-w
   Jhan MH, 2016, MOLECULES, V21, DOI 10.3390/molecules21091215
   Jiang X, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00168
   Khan Md Asaduzzaman, 2013, J Complement Integr Med, V10, DOI 10.1515/jcim-2013-0001
   Kifle ZD, 2020, J EVID-BASED INTEGR, V25, DOI 10.1177/2515690X20935827
   Kivrak I, 2020, INT J MED MUSHROOMS, V22, P559, DOI 10.1615/IntJMedMushrooms.2020035027
   Kozarski M, 2012, J FOOD COMPOS ANAL, V26, P144, DOI 10.1016/j.jfca.2012.02.004
   Lian N., 2019, Int J Dermatology Venereol, V2, P89, DOI [10.1097/01.JD9.0000559519.08557.fa, DOI 10.1097/01.JD9.0000559519.08557.FA]
   Liu HC, 2020, FOOD SCI HUM WELL, V9, P71, DOI 10.1016/j.fshw.2019.12.006
   Lo HC, 2020, INT J MED MUSHROOMS, V22, P417, DOI 10.1615/IntJMedMushrooms.2020034560
   Lu YP, 2021, POLYMERS-BASEL, V13, DOI 10.3390/polym13091441
   Meng FX, 2022, J HEALTHC ENG, V2022, DOI 10.1155/2022/7282453
   Pérez-Martínez P, 2017, NUTR REV, V75, P307, DOI 10.1093/nutrit/nux014
   Quagliariello V, 2022, J CARDIOVASC DEV DIS, V9, DOI 10.3390/jcdd9120423
   Raseta M, 2020, CHEM BIODIVERS, V17, DOI 10.1002/cbdv.202000683
   Ren YJ, 2022, NUTRIENTS, V14, DOI 10.3390/nu14112303
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Shi SH, 2022, VIRUSES-BASEL, V14, DOI 10.3390/v14020237
   Stojkovic D, 2019, S AFR J BOT, V120, P100, DOI 10.1016/j.sajb.2018.01.007
   Tang JF, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0201131
   Tel-Çayan G, 2021, J FOOD MEAS CHARACT, V15, P4608, DOI 10.1007/s11694-021-01034-1
   Vetter J, 2023, FOODS, V12, DOI 10.3390/foods12051009
   Wang KF, 2017, J FUNCT FOODS, V37, P90, DOI 10.1016/j.jff.2017.07.034
   Wang YQ, 2019, PHYTOTHER RES, V33, P2737, DOI 10.1002/ptr.6448
   Winska K, 2019, MOLECULES, V24, DOI 10.3390/molecules24224075
   Xie Yi-Zhen, 2016, Oncoscience, V3, P203, DOI 10.18632/oncoscience.316
   Xu LN, 2018, PHARMACOL RES, V130, P451, DOI 10.1016/j.phrs.2018.01.015
   [徐思源 Xu Siyuan], 2016, [南开大学学报. 自然科学版, Acta Scientiarum Naturalium Universitatis Nankaiensis], V49, P81
   Zhang S, 2022, J INTEGR AGR, V21, P1839, DOI 10.1016/S2095-3119(21)63871-6
   Zhang X, 2021, INT J BIOL MACROMOL, V166, P1387, DOI 10.1016/j.ijbiomac.2020.11.018
NR 55
TC 8
Z9 8
U1 2
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1424-8247
J9 PHARMACEUTICALS-BASE
JI Pharmaceuticals
PD JUN
PY 2023
VL 16
IS 6
AR 787
DI 10.3390/ph16060787
PG 20
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA K3WO6
UT WOS:001015777500001
PM 37375735
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Akamine, Y
   Millman, JF
   Uema, T
   Okamoto, S
   Yonamine, M
   Uehara, M
   Kozuka, C
   Kaname, T
   Shimabukuro, M
   Kinjo, K
   Mitsuta, M
   Watanabe, H
   Masuzaki, H
AF Akamine, Yukari
   Millman, Jasmine F.
   Uema, Tsugumi
   Okamoto, Shiki
   Yonamine, Masato
   Uehara, Moriyuki
   Kozuka, Chisayo
   Kaname, Tadashi
   Shimabukuro, Michio
   Kinjo, Kozen
   Mitsuta, Masayo
   Watanabe, Hirosuke
   Masuzaki, Hiroaki
TI Fermented brown rice beverage distinctively modulates the gut microbiota
   in Okinawans with metabolic syndrome: A randomized controlled trial
SO NUTRITION RESEARCH
LA English
DT Article
DE Brown rice; Fermented beverage; Gut microbiota; Short chain fatty acids;
   Metabolic syndrome; Obesity syndrome
ID ENDOPLASMIC-RETICULUM STRESS; HIGH-FAT-DIET; GAMMA-ORYZANOL; INTESTINAL
   MICROBIOTA; WHITE RICE; OBESITY; IMPACT
AB Accumulating evidence to date suggests that brown rice is superior to white rice in regard to its beneficial impact on a number of risk factors of the metabolic syndrome (MetS). However, little is known about the influence of fermented brown rice beverage on the gut microbiota in humans. We therefore hypothesized that its impact would beneficially alter the gut microbiota composition of patients with MetS. Using a 4-week randomized, single-arm study design, subjects (n = 40) were advised to consume a daily fermented brown rice beverage (BA) or fermented white rice beverage (WA) as a replacement of their main meal. Clinical and anthropometric measurements as well as fecal samples were collected at baseline and immediately after completion of the intervention. Gut microbiota was analyzed using 16S ribosomal RNA sequencing and capillary electrophoresis-time-of-flight mass spectrometry was used to measure plasma short-chain fatty acids. Interestingly, ingestion of BA in contrast to WA resulted in a unique elevation in the abundance of number of beneficial species belonging to the Clostridia class, associated with reduced inflammation, and increased short-chain fatty acid production: Lactobacillales bacterium DJF B280 ( P = .005), Butyrate producing bacterium A2 207 ( P = .012), and Firmicutes bacterium DJF VP44 ( P = .038). This study demonstrates that consumption of BA is effective to beneficially modulate the gut microbiota compared with WA in patients with MetS.(c) 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/)
C1 [Akamine, Yukari; Millman, Jasmine F.; Uema, Tsugumi; Okamoto, Shiki; Uehara, Moriyuki; Masuzaki, Hiroaki] Univ Ryukyus, Grad Sch Med, Dept Med 2, Div Endocrinol, Nishihara, Okinawa, Japan.
   [Yonamine, Masato] Univ Tsukuba, Fac Med, Div Clin Med, Lab Lab Sports Med, Tsukuba, Ibaraki, Japan.
   [Kozuka, Chisayo] RIKEN, YCI Lab Metab Epigenet, Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan.
   [Kaname, Tadashi] Natl Ctr Child Hlth & Dev, Dept Genome Med, Tokyo, Japan.
   [Shimabukuro, Michio] Fukushima Med Univ, Sch Med, Dept Diabet Endocrinol & Metab, Fukushima, Japan.
   [Kinjo, Kozen] Okinawa Hlth Promot Fdn, Onna, Okinawa, Japan.
   [Mitsuta, Masayo] Aizu Tenpo Co Ltd, Fukushima, Japan.
   [Watanabe, Hirosuke] Japan Sci & Technol Agcy JST, Ind Acad Collaborat, Fukushima, Japan.
   [Okamoto, Shiki; Masuzaki, Hiroaki] 207 Uehara, Nishihara, Okinawa 9030215, Japan.
C3 University of the Ryukyus; University of Tsukuba; RIKEN; National Center
   for Child Health & Development - Japan; Fukushima Medical University;
   Japan Science & Technology Agency (JST)
RP Okamoto, S; Masuzaki, H (corresponding author), 207 Uehara, Nishihara, Okinawa 9030215, Japan.
EM shiki@med.u-ryukyu.ac.jp; hiroaki@med.u-ryukyu.ac.jp
RI Kozuka, Chisayo/KEZ-9801-2024; Okamoto, Shiki/X-7274-2018
OI Okamoto, Shiki/0000-0002-2802-0527
FU Japan Society for the Promotion of Science (JSPS) , KAKENHI [20K08912];
   Japan Agency for Medical Research and Development (AMED)
   [JP19ek0410049]; Construction of Okinawa Science and Technology
   Innovation System; Setsuro Fuji Memorial the Osaka Foundation for
   Promotion of Fundamental Medical Research; Medical Rice Association;
   Council for Science, Technology and Innovation, Cross-ministerial
   Strategic Innovation Promotion Program, "Technologies for Creating
   Next-generation Agriculture, Forestry and Fisheries."; Grants-in-Aid for
   Scientific Research [20K08912, 21K14819] Funding Source: KAKEN
FX The present study was supported in part by Grants-in-Aid from the Japan
   Society for the Promotion of Science (JSPS) , KAKENHI (grant numbers:
   20K08912, 18K11079) ; Japan Agency for Medical Research and Development
   (AMED) (grant number: JP19ek0410049) ; Construction of Okinawa Science
   and Technology Innovation System; Setsuro Fuji Memorial the Osaka
   Foundation for Promotion of Fundamental Medical Re-search; Medical Rice
   Association and Council for Science, Technology and Innovation,
   Cross-ministerial Strategic Innovation Promotion Program, "Technologies
   for Creating Next-generation Agriculture, Forestry and Fisheries." JSPS,
   AMED, Construction of Okinawa Science and Technology Innovation System,
   Setsuro Fuji Memorial the Osaka Foundation for Promotion of Fundamental
   Medical Research, Medical Rice Association and Council for Science,
   Technology and Innovation, Cross-ministerial Strategic Innovation
   Promotion Program, "Technologies for Creating Next-generation
   Agriculture, Forestry and Fisheries," had no role in the study design,
   collection, analysis, interpretation, or writing of this article.
CR Allen JM, 2018, MED SCI SPORT EXER, V50, P747, DOI [10.1249/MSS.0000000000001495, 10.1249/mss.0000000000001495]
   Brunner E., 2020, HLTH JAPAN
   Chambers ES, 2015, P NUTR SOC, V74, P328, DOI 10.1017/S0029665114001657
   Coppola S, 2021, MOLECULES, V26, DOI 10.3390/molecules26030682
   Dhariwal A, 2017, NUCLEIC ACIDS RES, V45, pW180, DOI 10.1093/nar/gkx295
   Faul F, 2009, BEHAV RES METHODS, V41, P1149, DOI 10.3758/BRM.41.4.1149
   Festi D, 2014, WORLD J GASTROENTERO, V20, P16079, DOI 10.3748/wjg.v20.i43.16079
   Fu JY, 2015, CIRC RES, V117, P817, DOI 10.1161/CIRCRESAHA.115.306807
   Gaike AH, 2020, MSYSTEMS, V5, DOI 10.1128/mSystems.00578-19
   Gill SK, 2021, NAT REV GASTRO HEPAT, V18, P101, DOI 10.1038/s41575-020-00375-4
   Guo PT, 2020, J ANIM SCI BIOTECHNO, V11, DOI 10.1186/s40104-019-0402-1
   Hamajima H, 2019, BIOSCI BIOTECH BIOCH, V83, P1514, DOI 10.1080/09168451.2018.1562877
   Hamajima H, 2016, SPRINGERPLUS, V5, DOI 10.1186/s40064-016-2950-6
   Hirakawa A, 2019, J OBES CHRONIC DIS, P03, DOI [10.17756/jocd.2019-022, DOI 10.17756/JOCD.2019-022]
   Kim SW, 2013, DNA RES, V20, P241, DOI 10.1093/dnares/dst006
   Kohno M, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-65673-y
   Kozuka C, 2017, DIABETOLOGIA, V60, P1502, DOI 10.1007/s00125-017-4305-4
   Kozuka C, 2015, ENDOCRINOLOGY, V156, P1242, DOI 10.1210/en.2014-1748
   Kozuka C, 2012, DIABETES, V61, P3084, DOI 10.2337/db11-1767
   Leeming ER, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122862
   Lin D, 2018, BRIT J NUTR, V120, P1014, DOI 10.1017/S0007114518002465
   Louis P, 2017, ENVIRON MICROBIOL, V19, P29, DOI 10.1111/1462-2920.13589
   Maruki-Uchida H, 2020, BIOSCI BIOTECH BIOCH, V84, P1689, DOI 10.1080/09168451.2020.1756734
   Matsumoto M, 2012, SCI REP-UK, V2, DOI 10.1038/srep00233
   Millman J, 2020, EUR J NUTR, V59, P2411, DOI 10.1007/s00394-019-02088-0
   Morrison DJ, 2016, GUT MICROBES, V7, P189, DOI 10.1080/19490976.2015.1134082
   Nakayama T, 2017, NUTR DIABETES, V7, DOI 10.1038/nutd.2017.26
   Nichols E, 2019, LANCET NEUROL, V18, P88, DOI 10.1016/S1474-4422(18)30403-4
   Nogal A, 2021, GUT MICROBES, V13, DOI 10.1080/19490976.2021.1897212
   Oliphant K, 2019, MICROBIOME, V7, DOI 10.1186/s40168-019-0704-8
   Prasadi VPN, 2020, NUTRIENTS, V12, DOI 10.3390/nu12103045
   Reynolds AC, 2017, MOL METAB, V6, P12, DOI 10.1016/j.molmet.2016.11.004
   Sahyoun NR, 2006, AM J CLIN NUTR, V83, P124
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Salazar J, 2020, NUTRIENTS, V12, DOI 10.3390/nu12103039
   Saleh ASM, 2019, COMPR REV FOOD SCI F, V18, P1070, DOI 10.1111/1541-4337.12449
   San Gabriel A, 2018, NUTRIENTS, V10, DOI 10.3390/nu10020173
   Shen ZH, 2018, WORLD J GASTROENTERO, V24, P5, DOI 10.3748/wjg.v24.i1.5
   Shimabukuro M, 2014, BRIT J NUTR, V111, P310, DOI 10.1017/S0007114513002432
   Sugimoto M, 2010, METABOLOMICS, V6, P78, DOI 10.1007/s11306-009-0178-y
   Sun Q, 2010, ARCH INTERN MED, V170, P961, DOI 10.1001/archinternmed.2010.109
   Vourakis M, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22158074
   Wang C, 2020, DIABETES RES CLIN PR, V162, DOI 10.1016/j.diabres.2020.108116
   Wu H, 2020, CELL METAB, V32, P379, DOI 10.1016/j.cmet.2020.06.011
   Yu CX, 2019, J ENDOCRINOL, V243, P125, DOI 10.1530/JOE-19-0122
NR 45
TC 15
Z9 15
U1 2
U2 26
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
EI 1879-0739
J9 NUTR RES
JI Nutr. Res.
PD JUL
PY 2022
VL 103
BP 68
EP 81
DI 10.1016/j.nutres.2022.03.013
EA APR 2022
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1N0XC
UT WOS:000800385900008
PM 35500381
OA hybrid
DA 2025-06-11
ER

PT J
AU Nibali, L
   Donos, N
   Terranova, V
   Di Pino, A
   Di Marca, S
   Ferrara, V
   Pisano, M
   Scicali, R
   Rabuazzo, AM
   Purrello, F
   Malatino, L
AF Nibali, Luigi
   Donos, Nikos
   Terranova, Valentina
   Di Pino, Antonino
   Di Marca, Salvatore
   Ferrara, Viviana
   Pisano, Marcella
   Scicali, Roberto
   Rabuazzo, Agata Maria
   Purrello, Francesco
   Malatino, Lorenzo
TI Left ventricular geometry and periodontitis in patients with the
   metabolic syndrome
SO CLINICAL ORAL INVESTIGATIONS
LA English
DT Article
DE Metabolic syndrome; Periodontitis; Periodontal medicine; Cardiovascular
   disease
ID INTIMA-MEDIA THICKNESS; CLINICAL-IMPLICATIONS; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; ASSOCIATION; MASS; DISEASE; RISK; ATHEROSCLEROSIS;
   POPULATION
AB ObjectiveThe presence of periodontal disease (PD) in subjects affected by the metabolic syndrome (MetS) may affect their risk of developing cardiovascular disease. The aim of this cross-sectional study was to investigate the systemic impact of PD in MetS, by assessing measures of sub-clinical atherosclerosis and left ventricular mass and geometry.Materials and methodsA total of 103 patients undergoing treatment for MetS were examined for confirmation of diagnosis, blood sampling, and measures of pulse wave velocity (PWV), carotid intima-media thickness (c-IMT), left ventricular mass index (LVM), and relative wall thickness (RWT). All subjects underwent a detailed dental assessment, including measurements of DMFT (decayed-missing-filled teeth) and periodontal parameters.ResultsTen patients (10%) were diagnosed with healthy-mild periodontitis, 38 patients (37%) were diagnosed in the moderate periodontitis group, and 55 (53%) had severe periodontitis. A total of 37% of subjects were affected by dental caries. Linear regression analysis revealed that patients with severe PD had increased average ventricular RWT (adjusted p=0.032). Average full mouth probing pocket depth (PPD) was also associated with RWT (adjusted p=0.006). No associations between PD and c-IMT, PWV, and LVM were detected after adjusted analyses.ConclusionThis study suggests that periodontitis may be associated with concentric left ventricular remodeling, a predictive index of cardiovascular events.Clinical relevanceThe presence of periodontitis in patients with MetS might have an effect on left ventricular geometry. These findings stress the importance of prevention, diagnosis, and management of periodontitis in patients with MetS.Trail registrationNCT03297749
C1 [Nibali, Luigi; Donos, Nikos] Queen Mary Univ London, Barts & London Sch Med & Dent, Inst Dent, Ctr Oral Immunobiol & Regenerat Med, Turner St, London E1 2AD, England.
   [Nibali, Luigi; Donos, Nikos] Queen Mary Univ London, Barts & London Sch Med & Dent, Inst Dent, Ctr Oral Clin Res, Turner St, London E1 2AD, England.
   [Terranova, Valentina; Di Marca, Salvatore; Pisano, Marcella; Malatino, Lorenzo] Univ Catania, Dept Clin & Expt Med, Osped Cannizzaro, Catania, Italy.
   [Di Pino, Antonino; Ferrara, Viviana; Scicali, Roberto; Rabuazzo, Agata Maria; Purrello, Francesco] Univ Catania, Osped Garibaldi Nesima, Dept Clin & Expt Med, Catania, Italy.
C3 University of London; Queen Mary University London; University of
   London; Queen Mary University London; University of Catania; University
   of Catania; Presidio Ospedaliero Garibaldi-Nesima
RP Nibali, L (corresponding author), Queen Mary Univ London, Barts & London Sch Med & Dent, Inst Dent, Ctr Oral Immunobiol & Regenerat Med, Turner St, London E1 2AD, England.; Nibali, L (corresponding author), Queen Mary Univ London, Barts & London Sch Med & Dent, Inst Dent, Ctr Oral Clin Res, Turner St, London E1 2AD, England.
EM l.nibali@qmul.ac.uk
RI Scicali, Roberto/L-9587-2019; Malatino, Lorenzo/I-7319-2018; Di Pino,
   Antonino/ISB-0312-2023; Purrello, Francesco/K-9721-2016
OI Scicali, Roberto/0000-0002-7023-3649; PURRELLO, Francesco
   Salvatore/0000-0003-3313-8543; MALATINO, Lorenzo
   Salvatore/0000-0003-2944-2729
FU Department of Research Plan of the University of Catania, Department of
   Clinical and Experimental Medicine [A]
FX This study was funded by internal University funds and partially by the
   2016/2018 Department of Research Plan of the University of Catania,
   Department of Clinical and Experimental Medicine (project no. A).
CR Amar S, 2003, ARTERIOSCL THROM VAS, V23, P1245, DOI 10.1161/01.ATV.0000078603.90302.4A
   Andriankaja OM, 2010, AUST DENT J, V55, P252, DOI 10.1111/j.1834-7819.2010.01231.x
   Angeli F, 2003, HYPERTENSION, V41, P488, DOI 10.1161/01.HYP.0000056525.17476.D7
   Beck JD, 2001, ARTERIOSCL THROM VAS, V21, P1816, DOI 10.1161/hq1101.097803
   Benguigui C, 2010, J CLIN PERIODONTOL, V37, P601, DOI 10.1111/j.1600-051X.2010.01571.x
   D'Aiuto F, 2008, J CLIN ENDOCR METAB, V93, P3989, DOI 10.1210/jc.2007-2522
   DESIMONE G, 1992, J AM COLL CARDIOL, V20, P1251, DOI 10.1016/0735-1097(92)90385-Z
   Di Tullio MR, 2003, STROKE, V34, P2380, DOI 10.1161/01.STR.0000089680.77236.60
   Eguchi K, 2007, AM HEART J, V154, DOI 10.1016/j.ahj.2007.04.021
   Franek E, 2009, AM J HYPERTENS, V22, P203, DOI 10.1038/ajh.2008.330
   Ganau A, 1995, J HYPERTENS, V13, P1818
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Guerrero A, 2005, J CLIN PERIODONTOL, V32, P1096, DOI 10.1111/j.1600-051X.2005.00814.x
   Han DH, 2012, J PERIODONTOL, V83, P612, DOI 10.1902/jop.2011.110304
   Kebschull M, 2010, J DENT RES, V89, P879, DOI 10.1177/0022034510375281
   Kim YJ, 2010, ACTA CARDIOL, V65, P315, DOI 10.2143/AC.65.3.2050348
   Li Peng, 2011, Beijing Da Xue Xue Bao Yi Xue Ban, V43, P34
   Lorenz MW, 2007, CIRCULATION, V115, P459, DOI 10.1161/CIRCULATIONAHA.106.628875
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mealey BL, 2006, J PERIODONTOL, V77, P1289, DOI 10.1902/jop.2006.050459
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Nibali L, 2013, J CLIN ENDOCR METAB, V98, P913, DOI 10.1210/jc.2012-3552
   Ohnishi T, 2009, J PERIODONTAL RES, V44, P43, DOI 10.1111/j.1600-0765.2007.01060.x
   Orlandi M, 2014, ATHEROSCLEROSIS, V236, P39, DOI 10.1016/j.atherosclerosis.2014.06.002
   Page RC, 2007, J PERIODONTOL, V78, P1387, DOI 10.1902/jop.2007.060264
   Rizzo M, 2008, ATHEROSCLEROSIS, V200, P389, DOI 10.1016/j.atherosclerosis.2007.12.020
   Sarda T, 2016, CONTEMP CLIN DENT, V7, P343, DOI 10.4103/0976-237X.188559
   Schmitt A, 2015, J CLIN PERIODONTOL, V42, P977, DOI 10.1111/jcpe.12467
   Sethi S, 2014, INTEGR BLOOD PRESS C, V7, P29, DOI 10.2147/IBPC.S59535
   Söder B, 2007, J PERIODONTAL RES, V42, P361, DOI 10.1111/j.1600-0765.2006.00957.x
   Tomita Nilce Emy, 2005, J. Appl. Oral Sci., V13, P24
   Tonetti MS, 2007, NEW ENGL J MED, V356, P911, DOI 10.1056/NEJMoa063186
   Tsao CW, 2015, J AM HEART ASSOC, V4, DOI 10.1161/JAHA.115.002188
   Widlansky ME, 2003, J AM COLL CARDIOL, V42, P1149, DOI 10.1016/S0735-1097(03)00994-X
   Zanoli L, 2018, EUR J INTERN MED, V47, P36, DOI 10.1016/j.ejim.2017.08.020
   Zoccali C, 2001, J AM SOC NEPHROL, V12, P2768, DOI 10.1681/ASN.V12122768
NR 36
TC 17
Z9 17
U1 0
U2 3
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1432-6981
EI 1436-3771
J9 CLIN ORAL INVEST
JI Clin. Oral Investig.
PD JUN
PY 2019
VL 23
IS 6
BP 2695
EP 2703
DI 10.1007/s00784-018-2667-8
PG 9
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA HX5ME
UT WOS:000467444800014
PM 30350134
OA hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Ashford, AL
   Dunkley, TPJ
   Cockerill, M
   Rowlinson, RA
   Baak, LM
   Gallo, R
   Balmanno, K
   Goodwin, LM
   Ward, RA
   Lochhead, PA
   Guichard, S
   Hudson, K
   Cook, SJ
AF Ashford, Anne L.
   Dunkley, Tom P. J.
   Cockerill, Mark
   Rowlinson, Rachel A.
   Baak, Lisa M.
   Gallo, Raffaella
   Balmanno, Kathryn
   Goodwin, Louise M.
   Ward, Richard A.
   Lochhead, Pamela A.
   Guichard, Sylvie
   Hudson, Kevin
   Cook, Simon J.
TI Identification of DYRK1B as a substrate of ERK1/2 and characterisation
   of the kinase activity of DYRK1B mutants from cancer and metabolic
   syndrome
SO CELLULAR AND MOLECULAR LIFE SCIENCES
LA English
DT Article
DE DYRK1B; ERK1/2; KRAS; Phosphorylation; Protein kinase; RAF
ID PROTEIN-KINASE; REGULATED KINASE; CYCLIN D1; PANCREATIC-CANCER; MEDIATES
   SURVIVAL; BH3-ONLY PROTEIN; MIRK/DYRK1B; SPECIFICITY; INHIBITOR;
   PHOSPHORYLATION
AB The dual-specificity tyrosine-phosphorylation-regulated kinase, DYRK1B, is expressed de novo during myogenesis, amplified or mutated in certain cancers and mutated in familial cases of metabolic syndrome. DYRK1B is activated by cis auto-phosphorylation on tyrosine-273 (Y273) within the activation loop during translation but few other DYRK1B phosphorylation sites have been characterised to date. Here, we demonstrate that DYRK1B also undergoes trans-autophosphorylation on serine-421 (S421) in vitro and in cells and that this site contributes to DYRK1B kinase activity. Whilst a DYRK1B(S421A) mutant was completely defective for p-S421 in cells, DYRK1B inhibitors caused only a partial loss of p-S421 suggesting the existence of an additional kinase that could also phosphorylate DYRK1B S421. Indeed, a catalytically inactive DYRK1B(D239A) mutant exhibited very low levels of p-S421 in cells but this was increased by KRAS(G12V). In addition, selective activation of the RAF-MEK1/2-ERK1/2 signalling pathway rapidly increased p-S421 in cells whereas activation of the stress kinases JNK or p38 could not. S421 resides within a Ser-Pro phosphoacceptor motif that is typical for ERK1/2 and recombinant ERK2 phosphorylated DYRK1B at S421 in vitro. Our results show that DYRK1B is a novel ERK2 substrate, uncovering new links between two kinases involved in cell fate decisions. Finally, we show that DYRK1B mutants that have recently been described in cancer and metabolic syndrome exhibit normal or reduced intrinsic kinase activity.
C1 [Ashford, Anne L.; Baak, Lisa M.; Gallo, Raffaella; Balmanno, Kathryn; Lochhead, Pamela A.; Cook, Simon J.] Babraham Inst, Signalling Lab, Babraham Res Campus, Cambridge CB22 3AT, England.
   [Dunkley, Tom P. J.; Cockerill, Mark; Rowlinson, Rachel A.; Goodwin, Louise M.; Ward, Richard A.; Guichard, Sylvie; Hudson, Kevin] AstraZeneca, Alderley Pk, Macclesfield SK10 4TG, Cheshire, England.
   [Dunkley, Tom P. J.] Roche Innovat Ctr Basel, Basel, Switzerland.
   [Cockerill, Mark] Univ Manchester, Paterson Inst Canc Res, Manchester M20 4BX, Lancs, England.
   [Guichard, Sylvie] AstraZeneca, Waltham, MA 02451 USA.
C3 UK Research & Innovation (UKRI); Biotechnology and Biological Sciences
   Research Council (BBSRC); Babraham Institute; AstraZeneca; Roche
   Holding; Paterson Institute for Cancer Research; University of
   Manchester; AstraZeneca
RP Ashford, AL; Cook, SJ (corresponding author), Babraham Inst, Signalling Lab, Babraham Res Campus, Cambridge CB22 3AT, England.
EM anne.ashford@babraham.ac.uk; simon.cook@babraham.ac.uk
RI Gallo, Raffaella/IAN-3536-2023
OI Lochhead, Pamela/0000-0001-7498-0177; Baak, Lisa/0000-0001-5274-6371;
   Cook, Simon/0000-0001-9087-1616; Gallo, Raffaella/0000-0003-1234-5551;
   Balmanno, Kathryn/0000-0002-6417-3889
FU Biotechnology and Biological Sciences Research Council (BBSRC)
   [3068901]; BBSRC [BBS/E/B/000C0417, BB/L008793/1]; Association for
   International Cancer Research [AICR09-0257]; Erasmus Programme; BBSRC
   [BBS/E/B/000C0417, BB/L008793/1] Funding Source: UKRI
FX This work was supported by a Biotechnology and Biological Sciences
   Research Council (BBSRC) CASE PhD studentship [grant number 3068901
   (supporting A. A.)] awarded to AstraZeneca and the Babraham Institute
   (to S.C.), a BBSRC Institute Strategic Programme Grant [grant number
   BBS/E/B/000C0417 (to S.C.)], a BBSRC Project Grant [grant number
   BB/L008793/1 (to S.C)] and in part by the Association for International
   Cancer Research via a project grant [grant number AICR09-0257 (to S.C.].
   Lisa Baak, a visiting Masters student from the University of
   Duisburg-Essen, and Raffaella Gallo, were supported by scholarships from
   the Erasmus Programme.
CR Altafaj X, 2001, HUM MOL GENET, V10, P1915, DOI 10.1093/hmg/10.18.1915
   Alvarez M, 2007, MOL BIOL CELL, V18, P1167, DOI 10.1091/mbc.E06-08-0668
   Anjum R, 2008, NAT REV MOL CELL BIO, V9, P747, DOI 10.1038/nrm2509
   Aranda S, 2011, FASEB J, V25, P449, DOI 10.1096/fj.10-165837
   Ashford AL, 2014, BIOCHEM J, V457, P43, DOI 10.1042/BJ20130461
   Becker W, 1999, PROG NUCLEIC ACID RE, V62, P1
   Becker W, 1998, J BIOL CHEM, V273, P25893, DOI 10.1074/jbc.273.40.25893
   Chan DA, 2011, NAT REV DRUG DISCOV, V10, P351, DOI 10.1038/nrd3374
   Chen JY, 2013, MOL CELL, V52, P87, DOI 10.1016/j.molcel.2013.09.009
   Cheng KCC, 2009, CELL, V139, P560, DOI 10.1016/j.cell.2009.08.047
   Davies BR, 2007, MOL CANCER THER, V6, P2209, DOI 10.1158/1535-7163.MCT-07-0231
   Davis SJ, 2013, CLIN CANCER RES, V19, P1411, DOI 10.1158/1078-0432.CCR-12-3433
   Deng XB, 2003, J BIOL CHEM, V278, P41347, DOI 10.1074/jbc.M306780200
   Deng XB, 2009, CANCER RES, V69, P3317, DOI 10.1158/0008-5472.CAN-08-2903
   Dowjat WK, 2007, NEUROSCI LETT, V413, P77, DOI 10.1016/j.neulet.2006.11.026
   Ewings KE, 2007, EMBO J, V26, P2856, DOI 10.1038/sj.emboj.7601723
   Ewton DZ, 2003, INT J CANCER, V103, P21, DOI 10.1002/ijc.10743
   Fotaki V, 2002, MOL CELL BIOL, V22, P6636, DOI 10.1128/MCB.22.18.6636-6647.2002
   Fry DW, 2004, MOL CANCER THER, V3, P1427
   Gao JC, 2013, CANCER CELL INT, V13, DOI 10.1186/1475-2867-13-2
   Gao JC, 2009, CANCER BIOL THER, V8, P1678
   Göckler N, 2009, FEBS J, V276, P6324, DOI 10.1111/j.1742-4658.2009.07346.x
   Greenman C, 2007, NATURE, V446, P153, DOI 10.1038/nature05610
   Guimera J, 1999, GENOMICS, V57, P407, DOI 10.1006/geno.1999.5775
   Han JF, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0029702
   Harlow E, 1988, BIOCHEM EDUC, V17, P220, DOI [10.1016/0307-4412(89)90165-9, DOI 10.1016/0307-4412(89)90165-9]
   Himpel S, 2000, J BIOL CHEM, V275, P2431, DOI 10.1074/jbc.275.4.2431
   Himpel S, 2001, BIOCHEM J, V359, P497, DOI 10.1042/0264-6021:3590497
   Jin K, 2007, CANCER RES, V67, P7247, DOI 10.1158/0008-5472.can-06-4099
   Keramati AR, 2014, NEW ENGL J MED, V370, P1909, DOI 10.1056/NEJMoa1301824
   Kim D, 2004, BIOCHEM BIOPH RES CO, V323, P499, DOI 10.1016/j.bbrc.2004.08.102
   Kornev AP, 2008, P NATL ACAD SCI USA, V105, P14377, DOI 10.1073/pnas.0807988105
   Kuuselo R, 2007, CANCER RES, V67, P1943, DOI 10.1158/0008-5472.CAN-06-3387
   Lauth M, 2010, NAT STRUCT MOL BIOL, V17, P718, DOI 10.1038/nsmb.1833
   Leder S, 2003, BIOCHEM J, V372, P881, DOI 10.1042/BJ20030182
   Lee K, 2000, CANCER RES, V60, P3631
   Ley R, 2003, J BIOL CHEM, V278, P18811, DOI 10.1074/jbc.M301010200
   Ley R, 2004, J BIOL CHEM, V279, P8837, DOI 10.1074/jbc.M311578200
   Lochhead PA, 2005, CELL, V121, P925, DOI 10.1016/j.cell.2005.03.034
   Lochhead PA, 2003, BIOCHEM J, V374, P381, DOI 10.1042/BJ20030500
   Meloche S, 2007, ONCOGENE, V26, P3227, DOI 10.1038/sj.onc.1210414
   Mercer SE, 2005, J BIOL CHEM, V280, P25788, DOI 10.1074/jbc.M413594200
   Mirshahi T, 2014, NEW ENGL J MED, V371, P784, DOI 10.1056/NEJMc1408235
   Moller RS, 2008, AM J HUM GENET, V82, P1165, DOI 10.1016/j.ajhg.2008.03.001
   Morris EJ, 2013, CANCER DISCOV, V3, P742, DOI 10.1158/2159-8290.CD-13-0070
   Najas S, 2015, EBIOMEDICINE, V2, P120, DOI 10.1016/j.ebiom.2015.01.010
   Ogawa Y, 2010, NAT COMMUN, V1, DOI 10.1038/ncomms1090
   Papadopoulos C, 2011, J BIOL CHEM, V286, P5494, DOI 10.1074/jbc.M110.157909
   Sale MJ, 2013, BIOCHEM J, V450, P285, DOI 10.1042/BJ20121212
   Smith DJ, 1997, NAT GENET, V16, P28, DOI 10.1038/ng0597-28
   Soppa U, 2014, CELL CYCLE, V13, P2084, DOI 10.4161/cc.29104
   Soundararajan M, 2013, STRUCTURE, V21, P986, DOI 10.1016/j.str.2013.03.012
   Taira N, 2010, J BIOL CHEM, V285, P4909, DOI 10.1074/jbc.M109.042341
   TEJEDOR F, 1995, NEURON, V14, P287, DOI 10.1016/0896-6273(95)90286-4
   Todd DE, 2004, ONCOGENE, V23, P3284, DOI 10.1038/sj.onc.1207467
   Walte A, 2013, FEBS J, V280, P4495, DOI 10.1111/febs.12411
   Weston CR, 2003, ONCOGENE, V22, P1281, DOI 10.1038/sj.onc.1206261
NR 57
TC 26
Z9 31
U1 0
U2 8
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1420-682X
EI 1420-9071
J9 CELL MOL LIFE SCI
JI Cell. Mol. Life Sci.
PD FEB
PY 2016
VL 73
IS 4
BP 883
EP 900
DI 10.1007/s00018-015-2032-x
PG 18
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA DC9IQ
UT WOS:000369535300013
PM 26346493
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Santos, ABS
   Junges, M
   Silvello, D
   Macari, A
   de Araújo, BS
   Seligman, BG
   Duncan, BB
   Rohde, LEP
   Clausell, N
   Foppa, M
AF Santos, Angela B. S.
   Junges, Mauricio
   Silvello, Daiane
   Macari, Adriana
   de Araujo, Bruno S.
   Seligman, Beatriz G.
   Duncan, Bruce B.
   Rohde, Luis Eduardo P.
   Clausell, Nadine
   Foppa, Murilo
TI Early Change of Extracellular Matrix and Diastolic Parameters in
   Metabolic Syndrome
SO ARQUIVOS BRASILEIROS DE CARDIOLOGIA
LA English
DT Article
DE Metabolic Syndrome; Risk Factors; Extracellular Matrix; Diastole /
   physiopathology
ID ADULTS; ECHOCARDIOGRAPHY; RECOMMENDATIONS; PREVALENCE
AB Background: Metabolic syndrome (MS) is associated with increased cardiovascular risk. It is not clear whether myocardial changes showed in this syndrome, such as diastolic dysfunction, are due to the systemic effects of the syndrome, or to specific myocardial effects.
   Objectives: Compare diastolic function, biomarkers representing extracellular matrix activity (ECM), inflammation and cardiac hemodynamic stress in patients with the MS and healthy controls.
   Methods: MS patients (n = 76) and healthy controls (n=30) were submitted to a clinical assessment, echocardiographic study, and measurement of plasma levels of metalloproteinase-9 (MMP9), tissue inhibitor of metalloproteinase-1 (TIMP1), ultrasensitive-reactive-C-Protein (us-CRP), insulin resistance (HOMA-IR) and natriuretic peptide (NT-proBNP).
   Results: MS group showed lower E'wave (10.1 +/- 3.0 cm/s vs 11.9 +/- 2.6 cm/s, p = 0.005), increased A wave (63.4 +/- 14.1 cm/s vs. 53.1 +/- 8.9 cm/s; p < 0.001), E/E' ratio (8.0 +/- 2.2 vs. 6.3 +/- 1.2; p < 0.001), MMP9 (502.9 +/- 237.1 ng / mL vs. 330.4 +/- 162.7 ng/mL; p < 0.001), us-CRP (p = 0.001) and HOMA-IR (p < 0.001), but no difference for TIMP1 or NT-proBNP levels. In a multivariable analysis, only MMP9 was independently associated with MS.
   Conclusion: MS patients showed differences for echocardiographic measures of diastolic function, ECM activity, us-CRP and HOMA-IR when compared to controls. However, only MMP9 was independently associated with the MS. These findings suggest that there are early effects on ECM activity, which cannot be tracked by routine echocardiographic measures of diastolic function.
C1 [Santos, Angela B. S.; Seligman, Beatriz G.; Rohde, Luis Eduardo P.; Clausell, Nadine; Foppa, Murilo] Hosp Clin Porto Alegre, BR-90035903 Porto Alegre, RS, Brazil.
   [Santos, Angela B. S.; Junges, Mauricio; Silvello, Daiane; Macari, Adriana; de Araujo, Bruno S.; Seligman, Beatriz G.; Duncan, Bruce B.; Rohde, Luis Eduardo P.; Clausell, Nadine; Foppa, Murilo] Univ Fed Rio Grande do Sul, Porto Alegre, RS, Brazil.
C3 Hospital de Clinicas de Porto Alegre; Universidade Federal do Rio Grande
   do Sul
RP Santos, ABS (corresponding author), Hosp Clin Porto Alegre, Div Cardiovasc, Rua Ramiro Barcelos 2350,Sala 2061, BR-90035903 Porto Alegre, RS, Brazil.
EM angelabssantos@yahoo.com.br
RI Clausell, Nadine/C-7813-2016; Silvello, Daiane/U-5515-2019; Santos,
   Angela/V-5871-2019; Foppa, Murilo/V-4845-2019; Rohde, Luis/I-4216-2013;
   Duncan, Bruce/L-4140-2016
OI Duncan, Bruce/0000-0002-7491-2630
FU CNPq; FIPE/HCPA
FX This study was funded by CNPq and FIPE/HCPA.
CR Achong N, 2009, HEART, V95, P813, DOI 10.1136/hrt.2008.159020
   Aijaz B, 2008, MAYO CLIN PROC, V83, P1350, DOI 10.4065/83.12.1350
   Appleton CP, 1997, J AM SOC ECHOCARDIOG, V10, P271, DOI 10.1016/S0894-7317(97)70063-4
   de Kloet AD, 2010, PHYSIOL BEHAV, V100, P525, DOI 10.1016/j.physbeh.2010.03.018
   de las Fuentes L, 2007, EUR HEART J, V28, P553, DOI 10.1093/eurheartj/ehl526
   DESIMONE G, 1995, J AM COLL CARDIOL, V25, P1056, DOI 10.1016/0735-1097(94)00540-7
   Ford ES, 2010, J DIABETES, V2, P180, DOI 10.1111/j.1753-0407.2010.00078.x
   Ford ES, 2005, DIABETES CARE, V28, P2745, DOI 10.2337/diacare.28.11.2745
   Gonçalves FM, 2009, CLIN CHIM ACTA, V403, P173, DOI 10.1016/j.cca.2009.02.013
   Grothues F, 2002, AM J CARDIOL, V90, P29, DOI 10.1016/S0002-9149(02)02381-0
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Huggett RJ, 2004, HYPERTENSION, V44, P847, DOI 10.1161/01.HYP.0000147893.08533.d8
   Lang RM, 2006, EUR J ECHOCARDIOGR, V7, P79, DOI 10.1016/j.euje.2005.12.014
   Li YY, 2000, CARDIOVASC RES, V46, P214, DOI 10.1016/S0008-6363(00)00003-1
   López B, 2010, CIRCULATION, V121, P1645, DOI 10.1161/CIRCULATIONAHA.109.912774
   Maeda K, 1998, AM HEART J, V135, P825, DOI 10.1016/S0002-8703(98)70041-9
   Masugata H, 2006, HYPERTENS RES, V29, P897, DOI 10.1291/hypres.29.897
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Nagueh SF, 2009, EUR J ECHOCARDIOGR, V10, P165, DOI [10.1093/ejechocard/jep007, 10.1016/j.echo.2008.11.023]
   Ommen SR, 2000, CIRCULATION, V102, P1788
   Patel DA, 2009, AM J CARDIOL, V104, P69, DOI 10.1016/j.amjcard.2009.02.063
   Seligman BGS, 2011, METABOLISM, V60, P1736, DOI 10.1016/j.metabol.2011.05.006
   Tamura H, 2011, J CARD FAIL, V17, P210, DOI 10.1016/j.cardfail.2010.10.006
   Tayebjee MH, 2004, AM J HYPERTENS, V17, P770, DOI 10.1016/j.amjhyper.2004.06.023
NR 24
TC 7
Z9 7
U1 0
U2 2
PU ARQUIVOS BRASILEIROS CARDIOLOGIA
PI RIO DE JANEIRO
PA AVENIDA MARECHAL CAMARA 160-330 CENTRO, RIO DE JANEIRO, RJ 20 020-907,
   BRAZIL
SN 0066-782X
EI 1678-4170
J9 ARQ BRAS CARDIOL
JI Arq. Bras. Cardiol.
PD OCT
PY 2013
VL 101
IS 4
BP 311
EP 316
DI 10.5935/abc.20130182
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 278PC
UT WOS:000328901200009
PM 24008653
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tanofsky-Kraff, M
   Shomaker, LB
   Stern, EA
   Miller, R
   Sebring, N
   DellaValle, D
   Yanovski, SZ
   Hubbard, VS
   Yanovski, JA
AF Tanofsky-Kraff, M.
   Shomaker, L. B.
   Stern, E. A.
   Miller, R.
   Sebring, N.
   DellaValle, D.
   Yanovski, S. Z.
   Hubbard, V. S.
   Yanovski, J. A.
TI Children's binge eating and development of metabolic syndrome
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
DE binge eating; metabolic syndrome; children; adolescents; longitudinal
   studies
ID ADOLESCENTS; RISK; WEIGHT; TRIGLYCERIDE; ADIPOSITY; INSULIN;
   DISTRIBUTIONS; BEHAVIORS; OBESITY; STRESS
AB BACKGROUND: Binge eating predisposes children to excessive weight gain. However, it is unknown if pediatric binge eating predicts other obesity-associated adverse health outcomes.
   OBJECTIVE: The objective of this study was to investigate the relationship between binge eating and metabolic syndrome (MetS) in children.
   METHOD: Children aged 5-12 years at high risk for adult obesity, either because they were overweight/obese when first examined or because their parents were overweight/obese, were recruited from Washington, DC and its suburbs. Children completed a questionnaire assessment of binge eating at baseline and underwent measurements of MetS components at baseline and at a follow-up visit approximately 5 years later. Magnetic resonance imaging was used to measure the visceral adipose tissue (VAT) in a subset.
   RESULTS: In all, 180 children were studied between July 1996 and August 2010. Baseline self-reported binge eating presence was associated with a 5.33 greater odds of having MetS at follow-up (95% confidence interval (CI): 1.47, 19.27, P = 0.01). The association between binge eating and body mass index (BMI) only partially explained changes in MetS components: baseline binge eating predicted higher follow-up triglycerides, even after accounting for baseline triglycerides, baseline BMI, BMI change, sex, race, baseline age and time in study (P = 0.05). Also, adjusting for baseline VAT and demographics, baseline binge eating predicted greater follow-up L2-3 VAT (P = 0.01).
   DISCUSSION: Children's reports of binge eating predicted development of MetS, worsening triglycerides and increased VAT. The excessive weight gain associated with children's binge eating partly explained its adverse metabolic health outcomes. Reported binge eating may represent an early behavioral marker upon which to focus interventions for obesity and MetS.
C1 [Tanofsky-Kraff, M.; Shomaker, L. B.; Stern, E. A.; Miller, R.; Yanovski, S. Z.; Yanovski, J. A.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Dev Endocrinol & Genet, Sect Growth & Obes, NIH,DHHS,Hatfield Clin Res Ctr, Bethesda, MD 20892 USA.
   [Tanofsky-Kraff, M.; Shomaker, L. B.; Miller, R.] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA.
   [Sebring, N.; DellaValle, D.] NIH, Ctr Clin, Dept Nutr, Bethesda, MD 20892 USA.
   [Yanovski, S. Z.] NIDDKD, Div Digest Dis & Nutr, Bethesda, MD 20892 USA.
   [Hubbard, V. S.] NIH, Div Nutr Res Coordinat, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver
   National Institute of Child Health & Human Development (NICHD);
   Uniformed Services University of the Health Sciences - USA; National
   Institutes of Health (NIH) - USA; NIH Clinical Center (CC); National
   Institutes of Health (NIH) - USA; NIH National Institute of Diabetes &
   Digestive & Kidney Diseases (NIDDK); National Institutes of Health (NIH)
   - USA
RP Yanovski, JA (corresponding author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Dev Endocrinol & Genet, Sect Growth & Obes, NIH,DHHS,Hatfield Clin Res Ctr, 10 Ctr Dr,Room 1E-3330,MSC 1103, Bethesda, MD 20892 USA.
EM jy15i@nih.gov
OI Yanovski, Jack/0000-0001-8542-1637; Radin, Rachel/0000-0003-3776-9481;
   DellaValle, Diane M./0000-0002-3855-432X
FU NICHD [1F32HD056762, 1ZIAHD000641]; NIMHD
FX The authors' responsibilities were as follows: MTK, LBS, SZY and JAY
   designed the study; MTK, LBS, EAS, RM, NS, DD, SZY, VSH and JAY analyzed
   and interpreted the data and drafted of the manuscript. All authors
   contributed to the collection and assembly of data, provided critical
   revision of the article for content and approved the final version of
   the manuscript. We thank the volunteers who participated for their help
   in completing these studies. The funding organization played no role in
   design and conduct of the study; collection, management, analysis and
   interpretation of the data; nor preparation or review of the manuscript.
   None of the authors declare any conflict of interest. This work was
   supported by National Research Service Award 1F32HD056762 from the NICHD
   (to LBS) and Intramural Research Program Grant 1ZIAHD000641 from the
   NICHD with supplemental funding from NIMHD (to JAY). ClinicalTrials.gov
   IDs: NCT00001522, NCT00001195.
CR Allison P.D., 2009, The SAGE handbook of quantitative methods in psychology
   [Anonymous], 2000, Diagnostic and statistical manual of mental disorders: DSM-IV-TR, V4th
   [Anonymous], 1977, Exploratory data analysis
   Behrens JT, 1997, PSYCHOL METHODS, V2, P131, DOI 10.1037/1082-989X.2.2.131
   Butte NF, 2005, PEDIATR RES, V58, P1243, DOI 10.1203/01.pdr.0000185272.46705.18
   Casazza K, 2009, ACTA PAEDIATR, V98, P1965, DOI 10.1111/j.1651-2227.2009.01474.x
   CHRISTENSEN B, 1980, PEDIATR RES, V14, P194, DOI 10.1203/00006450-198003000-00004
   Cruz ML, 2004, J CLIN ENDOCR METAB, V89, P108, DOI 10.1210/jc.2003-031188
   Epel ES, 2000, PSYCHOSOM MED, V62, P623, DOI 10.1097/00006842-200009000-00005
   Falkner B, 1996, PEDIATRICS, V98, P649
   FARQUHAR JW, 1966, J CLIN INVEST, V45, P1648, DOI 10.1172/JCI105472
   Fernández JR, 2004, J PEDIATR-US, V145, P439, DOI 10.1016/j.jpeds.2004.06.044
   Field AE, 2003, PEDIATRICS, V112, P900, DOI 10.1542/peds.112.4.900
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Gustafson JK, 2009, J CLIN ENDOCR METAB, V94, P4828, DOI 10.1210/jc.2008-2665
   Hickman TB, 1998, PREV MED, V27, P879, DOI 10.1006/pmed.1998.0376
   Huang TTK, 2008, J PEDIATR-US, V152, P185, DOI 10.1016/j.jpeds.2007.08.007
   Hudson JI, 2010, AM J CLIN NUTR, V91, P1568, DOI 10.3945/ajcn.2010.29203
   Johnson WG, 1999, INT J EAT DISORDER, V26, P301, DOI 10.1002/(SICI)1098-108X(199911)26:3<301::AID-EAT8>3.0.CO;2-M
   Kuczmarski RJ, 2002, Advance Data, V11, P1
   Kuo LE, 2008, ANN NY ACAD SCI, V1148, P232, DOI 10.1196/annals.1410.035
   Li SX, 2003, JAMA-J AM MED ASSOC, V290, P2271, DOI 10.1001/jama.290.17.2271
   Lourenço BH, 2008, APPETITE, V50, P223, DOI 10.1016/j.appet.2007.07.004
   Morgan CM, 2002, INT J EAT DISORDER, V31, P430, DOI 10.1002/eat.10038
   Morrison JA, 2008, J PEDIATR-US, V152, P201, DOI 10.1016/j.jpeds.2007.09.010
   Morrison JA, 2007, PEDIATRICS, V120, P340, DOI 10.1542/peds.2006-1699
   National Center for Health Statistics N, 1996, NHANES 3 ANTHR PROC
   Roehrig M, 2009, OBESITY, V17, P481, DOI 10.1038/oby.2008.560
   Schafer JL, 2002, PSYCHOL METHODS, V7, P147, DOI 10.1037//1082-989X.7.2.147
   SEGALL MM, 1970, ARCH DIS CHILD, V45, P393, DOI 10.1136/adc.45.241.393
   Sierra-Johnson J, 2008, OBESITY, V16, P1302, DOI 10.1038/oby.2008.203
   Spitzer R., 1993, QUESTIONNAIRE EATING
   Tanofsky-Kraff M, 2003, INT J EAT DISORDER, V33, P213, DOI 10.1002/eat.10128
   Tanofsky-Kraff M, 2006, PEDIATRICS, V117, P1203, DOI 10.1542/peds.2005-1329
   Tanofsky-Kraff M, 2007, J CONSULT CLIN PSYCH, V75, P901, DOI 10.1037/0022-006X.75.6.901
   Tanofsky-Kraff M, 2007, OBESITY, V15, P1345, DOI 10.1038/oby.2007.162
   Tanofsky-Kraff M, 2008, ISSUES CLIN CHILD PS, P43
   Tanofsky-Kraff M, 2009, AM J CLIN NUTR, V89, P738, DOI 10.3945/ajcn.2008.26886
   Theim Kelly R, 2007, Eat Behav, V8, P258, DOI 10.1016/j.eatbeh.2006.10.001
   Vanhala M, 1999, ANN MED, V31, P236, DOI 10.3109/07853899908995885
   Vikram NK, 2006, ATHEROSCLEROSIS, V186, P193, DOI 10.1016/j.atherosclerosis.2005.07.015
   Whincup PH, 2005, CIRCULATION, V112, P1789, DOI 10.1161/CIRCULATIONAHA.104.532663
   Wormser D, 2011, LANCET, V377, P1085, DOI 10.1016/S0140-6736(11)60105-0
   Yusuf S, 2005, LANCET, V366, P1640, DOI 10.1016/S0140-6736(05)67663-5
NR 44
TC 96
Z9 101
U1 2
U2 21
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD JUL
PY 2012
VL 36
IS 7
BP 956
EP 962
DI 10.1038/ijo.2011.259
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 972JL
UT WOS:000306273300011
PM 22234282
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Valenti, L
   Dongiovanni, P
   Motta, BM
   Swinkels, DW
   Bonara, P
   Rametta, R
   Burdick, L
   Frugoni, C
   Fracanzani, AL
   Fargion, S
AF Valenti, Luca
   Dongiovanni, Paola
   Motta, Benedetta Maria
   Swinkels, Dorine W.
   Bonara, Paola
   Rametta, Raffaela
   Burdick, Larry
   Frugoni, Cecelia
   Fracanzani, Anna Ludovica
   Fargion, Silvia
TI Serum Hepcidin and Macrophage Iron Correlate With MCP-1 Release and
   Vascular Damage in Patients With Metabolic Syndrome Alterations
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE atherosclerosis; cytokines; free radicals/free-radical scavengers;
   macrophages; risk factors; iron
ID CORONARY-HEART-DISEASE; MONOCYTE CHEMOATTRACTANT PROTEIN-1; HFE
   GENE-MUTATIONS; OXIDATIVE STRESS; HEMOCHROMATOSIS; LIVER; RISK;
   EXPRESSION; STORES; ATHEROSCLEROSIS
AB Objective-Increased body iron stores and hepcidin have been hypothesized to promote atherosclerosis by inducing macrophage iron accumulation and release of cytokines, but direct demonstration in human cells is lacking. The aim of this study was to evaluate the effect of iron on cytokine release in monocytes ex vivo and the correlation with vascular damage and to evaluate the relationship among serum levels of hepcidin, cytokines, and vascular damage in patients with metabolic syndrome alterations.
   Methods and Results-Manipulation of iron status with ferric ammonium citrate and hepcidin-25 induced monocyte chemoattractant protein (MCP)-1 and interleukin-6 in human differentiating monocytes of patients with hyperferritinemia associated with the metabolic syndrome (n = 11), but not in subjects with hemochromatosis or HFE mutations impairing iron accumulation (n = 15), and the degree of induction correlated with the presence of carotid plaques, detected by echocolor-Doppler. In monocytes of healthy subjects (n = 7), iron and hepcidin increased the mRNA levels and release of MCP-1, but not of interleukin-6. In 130 patients with metabolic alterations, MCP-1 levels, as detected by ELISA, were correlated with hepcidin-25 measured by time-of-flight mass spectrometry (P = 0.005) and were an independent predictor of the presence of carotid plaques (P = 0.05).
   Conclusion-Hepcidin and macrophage iron correlate with MCP-1 release and vascular damage in high-risk individuals with metabolic alterations. (Arterioscler Thromb Vasc Biol. 2011;31:683-690.)
C1 [Valenti, Luca] Univ Milan, Osped Maggiore Policlin Ca Granda IRCCS, Dept Internal Med, Ctr Malattie Metab Fegato, I-20122 Milan, Italy.
   [Swinkels, Dorine W.] Radboud Univ Nijmegen, Med Ctr, Dept Lab Med, Lab Genet Endocrine & Metab Dis, NL-6525 ED Nijmegen, Netherlands.
C3 University of Milan; IRCCS Ca Granda Ospedale Maggiore Policlinico;
   Radboud University Nijmegen
RP Valenti, L (corresponding author), Univ Milan, Osped Maggiore Policlin Ca Granda IRCCS, Dept Internal Med, Ctr Malattie Metab Fegato, Via F Sforza 35, I-20122 Milan, Italy.
EM luca.valenti@unimi.it
RI Dongiovanni, Paola/AAC-9965-2019; Swinkels, Dorine/H-8098-2014; Motta,
   Benedetta/AAA-8559-2020; Fracanzani, Anna Ludovica/J-8986-2018; Valenti,
   Luca/B-3695-2009
OI Dongiovanni, Paola/0000-0003-4343-7213; rametta,
   raffaela/0000-0003-0091-9394; Fracanzani, Anna
   Ludovica/0000-0001-5918-0171; Motta, Benedetta
   Maria/0000-0002-6681-2170; Valenti, Luca/0000-0001-8909-0345
FU University of Milano; Ricerca Corrente; Progetto a Concorso
FX This work was supported by FIRST/PUR University of Milano 2006-2008;
   Ricerca Corrente 2006, 2007; and Progetto a Concorso 2009-2010
   Fondazione Ospedale Policlinico MaRE IRCCS.
CR Adams PC, 2005, NEW ENGL J MED, V352, P1769, DOI 10.1056/NEJMoa041534
   Agarwal R, 2006, KIDNEY INT, V69, P1259, DOI 10.1038/sj.ki.5000164
   Amasyali B, 2009, INT J CARDIOL, V136, P356, DOI 10.1016/j.ijcard.2008.04.080
   Bekri S, 2006, GASTROENTEROLOGY, V131, P788, DOI 10.1053/j.gastro.2006.07.007
   Cairo G, 1997, BLOOD, V89, P2546, DOI 10.1182/blood.V89.7.2546
   Day SM, 2003, CIRCULATION, V107, P2601, DOI 10.1161/01.CIR.0000066910.02844.D0
   Dongiovanni P, 2008, AM J PATHOL, V172, P738, DOI 10.2353/ajpath.2008.070097
   Duffy SJ, 2001, CIRCULATION, V103, P2799
   Engberink MF, 2010, ATHEROSCLEROSIS, V211, P520, DOI 10.1016/j.atherosclerosis.2010.03.018
   Fargion S, 2001, BLOOD, V97, P3707, DOI 10.1182/blood.V97.12.3707
   Fracanzani AL, 2008, AM J MED, V121, P72, DOI 10.1016/j.amjmed.2007.08.041
   Garuti C, 2010, GASTROENTEROLOGY, V139, P315, DOI 10.1053/j.gastro.2010.03.043
   Gu L, 1998, MOL CELL, V2, P275, DOI 10.1016/S1097-2765(00)80139-2
   Kraml PJ, 2005, METABOLISM, V54, P453, DOI 10.1016/j.metabol.2004.10.012
   Kroot JJC, 2010, CLIN CHEM, V56, P1570, DOI 10.1373/clinchem.2010.149187
   Lapenna D, 2007, FREE RADICAL BIO MED, V42, P492, DOI 10.1016/j.freeradbiomed.2006.11.014
   Lawless MW, 2007, TISSUE ANTIGENS, V70, P294, DOI 10.1111/j.1399-0039.2007.00895.x
   Lee TS, 1999, CIRCULATION, V99, P1222, DOI 10.1161/01.CIR.99.9.1222
   LIAO YL, 1994, AM J EPIDEMIOL, V139, P704, DOI 10.1093/oxfordjournals.aje.a117060
   Luc G, 2003, ARTERIOSCL THROM VAS, V23, P1255, DOI 10.1161/01.ATV.0000079512.66448.1D
   Morita T, 2005, ARTERIOSCL THROM VAS, V25, P1786, DOI 10.1161/01.ATV.0000178169.95781.49
   Munsaka Sody M, 2009, Immunol Immunogenet Insights, V1, P15
   Nagy E, 2010, ARTERIOSCL THROM VAS, V30, P1347, DOI 10.1161/ATVBAHA.110.206433
   NELKEN NA, 1991, J CLIN INVEST, V88, P1121, DOI 10.1172/JCI115411
   Nemeth E, 2004, SCIENCE, V306, P2090, DOI 10.1126/science.1104742
   Pietrangelo A, 2007, HEPATOLOGY, V46, P1291, DOI 10.1002/hep.21886
   PIRART J, 1971, DIABETOLOGIA, V7, P227, DOI 10.1007/BF01211873
   Recalcati S, 2006, HAEMATOLOGICA, V91, P303
   Roest M, 1999, CIRCULATION, V100, P1268, DOI 10.1161/01.CIR.100.12.1268
   Saha P, 2009, CURR OPIN PHARMACOL, V9, P109, DOI 10.1016/j.coph.2008.12.017
   Salonen JT, 1998, AM J EPIDEMIOL, V148, P445
   Scaccabarozzi A, 2000, BRIT J HAEMATOL, V110, P978, DOI 10.1046/j.1365-2141.2000.02280.x
   SEMPOS CT, 1994, NEW ENGL J MED, V330, P1119, DOI 10.1056/NEJM199404213301604
   Silva MCP, 2010, EUR J EPIDEMIOL, V25, P643, DOI 10.1007/s10654-010-9489-6
   Sullivan JL, 2007, EXP BIOL MED, V232, P1014, DOI 10.3181/0703-MR-54
   SULLIVAN JL, 1981, LANCET, V1, P1293
   SWINKELS DW, 2008, EUR IR CLUB SEPT 18
   Theurl I, 2008, BLOOD, V111, P2392, DOI 10.1182/blood-2007-05-090019
   VALENTI L, NUTR METAB IN PRESS
   Valenti L, 2008, HEPATOLOGY, V47, P1794, DOI 10.1002/hep.22059
   Valenti L, 2007, AM J GASTROENTEROL, V102, P1251, DOI 10.1111/j.1572-0241.2007.01192.x
   Valenti L, 2007, AM J NEPHROL, V27, P101, DOI 10.1159/000099635
   Valenti L, 2010, GASTROENTEROLOGY, V138, P905, DOI 10.1053/j.gastro.2009.11.013
   van der A DL, 2006, EUR J CLIN INVEST, V36, P682, DOI 10.1111/j.1365-2362.2006.01711.x
   Wang LJ, 2008, J IMMUNOL, V181, P2723, DOI 10.4049/jimmunol.181.4.2723
   Yuan XM, 2004, FREE RADICAL RES, V38, P1133, DOI 10.1080/10715760400011692
   Zacharski LR, 2007, JAMA-J AM MED ASSOC, V297, P603, DOI 10.1001/jama.297.6.603
   Zager RA, 2005, KIDNEY INT, V68, P1533, DOI 10.1111/j.1523-1755.2005.00565.x
   Zhang WJ, 2010, EXP BIOL MED, V235, P633, DOI 10.1258/ebm.2009.009229
NR 49
TC 81
Z9 87
U1 1
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD MAR
PY 2011
VL 31
IS 3
BP 683
EP 690
DI 10.1161/ATVBAHA.110.214858
PG 8
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 722CZ
UT WOS:000287409900031
PM 21183736
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Mauss, D
   Herr, RM
   Jarczok, MN
   Motoc, I
   Fischer, JE
   Bosch, A
AF Mauss, Daniel
   Herr, Raphael M.
   Jarczok, Marc N.
   Motoc, Irina
   Fischer, Joachim E.
   Bosch, A.
TI The association of cortisol levels with leukocyte distribution is
   disrupted in the metabolic syndrome
SO OBESITY RESEARCH & CLINICAL PRACTICE
LA English
DT Article
DE metabolic syndrome; inflammation; glucocorticoid sensitivity;
   glucocorticoid resistance; cortisol
ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; GLUCOCORTICOID SENSITIVITY;
   SALIVARY CORTISOL; RISK-FACTORS; RESISTANCE; INFLAMMATION; PREVALENCE;
   MECHANISMS; STRESS
AB Background: Leukocyte glucocorticoid sensitivity (GCS) pertains to the responsivity of leukocytes to the regulating actions of glucocorticoids, such as cortisol. Impaired endocrine regulation may link the metabolic syndrome (MetS) to the development of cardiovascular disease. We tested if the physiological association between endogenous cortisol levels and peripheral leukocyte composition becomes disrupted in individuals with MetS. Methods: MetS was assessed among 689 German industrial employees. The covariance between cortisol levels and hematologic parameters (i.e., proportions of neutrophils and lymphocytes) and their ratio was explored, which has been proposed as a proxy for GCS in vivo. Cortisol level before blood collection was assessed by repeated saliva collection, and the area under the curve was calculated. Linear regression models were adjusted for potential confounders including age, gender, BMI, income, and lifestyle factors. Results: Cortisol levels did not differ between subgroups. Participants without MetS (n = 552) showed the expected association of cortisol with hematologic parameters (i3 = 0.207 to 0.216; p values 0.001). No association (i3 = 0.078 to 0.083; p values 0.10) was found among those with MetS (n = 137), consistent with a reduced GCS. Analyses of separate MetS components showed that reduced GCS was associated specifically with decreased high-density lipoprotein and elevated fasting plasma glucose. Conclusions: Utilizing a novel statistical approach to infer GCS, this study provided first epidemiological evidence of aberrant physiological regulation of leukocyte distribution by endogenous cortisol levels among individuals with MetS. These findings underline the idea that MetS may involve disruption of endocrine-immune regulation. (c) 2020 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
C1 [Mauss, Daniel; Herr, Raphael M.; Fischer, Joachim E.] Heidelberg Univ, Med Fac Mannheim, Mannheim Inst Publ Hlth Social & Prevent Med, Ludolf Krehl Str 7, D-68167 Mannheim, Germany.
   [Jarczok, Marc N.] Ulm Univ, Clin Psychosomat Med & Psychotherapy, Albert Einstein Allee 23, D-89081 Ulm, Germany.
   [Motoc, Irina] Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Dept Epidemiol & Biostat, Boelelaan 1117, Amsterdam, Netherlands.
   [Bosch, A.] Univ Amsterdam, Dept Clin Psychol, Postbus 15933, NL-1001 NK Amsterdam, Netherlands.
C3 Ruprecht Karls University Heidelberg; Ulm University; University of
   Amsterdam; University of Amsterdam
RP Mauss, D (corresponding author), Heidelberg Univ, Med Fac Mannheim, Mannheim Inst Publ Hlth Social & Prevent Med, Ludolf Krehl Str 7, D-68167 Mannheim, Germany.
EM dmousetrap@googlemail.com; raphael.herr@medma.uni-heidelberg.de;
   marc.jarczok@uniklinik-ulm.de; i.motoc@amsterdamumc.nl;
   joachim.fischer@medma.uni-heidelberg.de; J.A.Bosch@uva.nl
RI Herr, Raphael/GYU-5115-2022; Jarczok, Marc N./A-2383-2014
OI Motoc, Irina/0000-0002-0046-7837; Jarczok, Marc N./0000-0002-6055-385X
CR [Anonymous], 1993, How to detect and handle outliers
   Barnes PJ, 2009, LANCET, V373, P1905, DOI 10.1016/S0140-6736(09)60326-3
   Bellingrath S, 2013, BIOL PSYCHOL, V92, P403, DOI 10.1016/j.biopsycho.2012.12.003
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   Cohen S, 2012, P NATL ACAD SCI USA, V109, P5995, DOI 10.1073/pnas.1118355109
   Cole SW, 2008, BRAIN BEHAV IMMUN, V22, P1049, DOI 10.1016/j.bbi.2008.02.006
   Dupuy AM, 2007, GERONTOLOGY, V53, P329, DOI 10.1159/000103555
   FAUCI AS, 1976, ANN INTERN MED, V84, P304, DOI 10.7326/0003-4819-84-3-304
   FAUCI AS, 1976, CLIN EXP IMMUNOL, V24, P54
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Herr RM, 2015, PSYCHOSOM MED, V77, P527, DOI 10.1097/PSY.0000000000000185
   Jessop DS, 2001, J CLIN ENDOCR METAB, V86, P4109, DOI 10.1210/jc.86.9.4109
   KIRSCHBAUM C, 1994, PSYCHONEUROENDOCRINO, V19, P313, DOI 10.1016/0306-4530(94)90013-2
   Kivimäki M, 2005, ARCH INTERN MED, V165, P2245, DOI 10.1001/archinte.165.19.2245
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   Miller R, 2016, PSYCHONEUROENDOCRINO, V73, P16, DOI 10.1016/j.psyneuen.2016.07.201
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   Moraitis AG, 2017, J STEROID BIOCHEM, V165, P114, DOI 10.1016/j.jsbmb.2016.03.023
   Noppe G, 2016, INT J OBESITY, V40, P1503, DOI 10.1038/ijo.2016.113
   Pedersen JM, 2016, INT J CARDIOL, V215, P41, DOI 10.1016/j.ijcard.2016.04.076
   Pruessner JC, 2003, PSYCHONEUROENDOCRINO, V28, P916, DOI 10.1016/S0306-4530(02)00108-7
   Quax RA, 2013, NAT REV ENDOCRINOL, V9, P670, DOI 10.1038/nrendo.2013.183
   Ridker PM, 2004, CIRCULATION, V109, P2818, DOI 10.1161/01.CIR.0000132467.45278.59
   Rosmond Roland, 2008, J Cardiometab Syndr, V3, P132, DOI 10.1111/j.1559-4572.2008.00008.x
   Silverman MN, 2012, ANN NY ACAD SCI, V1261, P55, DOI 10.1111/j.1749-6632.2012.06633.x
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Stalder T, 2013, J CLIN ENDOCR METAB, V98, P2573, DOI 10.1210/jc.2013-1056
   Suliga E, 2016, ANN AGR ENV MED, V23, P631, DOI 10.5604/12321966.1226858
   Syed AA, 2006, OBESITY, V14, P759, DOI 10.1038/oby.2006.86
   Valtorta NK, 2016, HEART, V102, P1009, DOI 10.1136/heartjnl-2015-308790
   Walker BR, 2006, DIABETIC MED, V23, P1281, DOI 10.1111/j.1464-5491.2006.01998.x
   Walker BR, 2007, EUR J ENDOCRINOL, V157, P545, DOI 10.1530/EJE-07-0455
   Wang YB, 2013, CURR PHARM DESIGN, V19, P4799, DOI 10.2174/1381612811319270002
   Weinstein Maxine., 2007, Biosocial Surveys
   Wirtz PH, 2004, AM J HYPERTENS, V17, P489, DOI 10.1016/j.amjhyper.2004.01.010
   Zhang Y, 2019, J BIOL REG HOMEOS AG, V33, P427
NR 36
TC 5
Z9 5
U1 0
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-403X
EI 1878-0318
J9 OBES RES CLIN PRACT
JI Obes. Res. Clin. Pract.
PD JAN-FEB
PY 2021
VL 15
IS 1
BP 78
EP 84
DI 10.1016/j.orcp.2020.12.003
EA FEB 2021
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA RB1JY
UT WOS:000631873900013
PM 33371996
DA 2025-06-11
ER

PT J
AU Kara, E
   Kahraman, E
   Dayar, E
   Anacak, GY
   Demir, O
   Gidener, S
   Atabey, N
   Durmus, N
AF Kara, Erkan
   Kahraman, Erkan
   Dayar, Ezgi
   Anacak, Gunay Yetik
   Demir, Omer
   Gidener, Sedef
   Atabey, Nese
   Durmus, Nergiz
TI The role of resistin on metabolic syndrome-induced erectile dysfunction
   and the possible therapeutic effect of Boldine
SO ANDROLOGY
LA English
DT Article
DE metabolic syndrome; erectile dysfunction; resistin; nitric oxide;
   Boldine
ID IMPROVES ENDOTHELIAL FUNCTION; NITRIC-OXIDE SYNTHASE; INSULIN
   SENSITIVITY; OXIDATIVE STRESS; OBESITY; ANTIOXIDANT; PREVALENCE;
   ADIPOKINES; PROTECTS; FRUCTOSE
AB Background Resistin is known as a potential mediator of obesity-associated insulin resistance. The high resistin level disrupts nitric oxide (NO)-mediated relaxation which is also important in erectile function. An antioxidant alkaloid, Boldine, is known as anti-diabetic and protects endothelial functions. Objectives We aimed to investigate resistin expression in penile tissue in the presence of insulin resistance (IR) and the effect of Boldine treatment on erectile functions in the metabolic syndrome (MetS) rat model. Materials and methods Wistar rats were randomly divided into three groups: Control, MetS, and boldine treated MetS group. MetS parameters were assessed by serum triglycerides (TG), uric acid (UA), glucose, insulin levels, HOMA index, and waist circumference (WC)/tibia length (TL) ratio. To evaluate erectile functions, intracavernous pressure (ICP)/mean arterial pressure (MAP) ratio was performed during cavernous nerve stimulation. Protein expressions of resistin, endothelial nitric oxide synthase (eNOS), p(S1177) eNOS, and insulin receptor-beta were evaluated by Western blotting. Results TG, glucose, insulin levels, weight, WC/TL ratio, HOMA index and resistin expression in penile tissue were significantly increased and ICP/MAP values, and p (S1177) eNOS expression in penile tissue were decreased in MetS group. Boldine treatment enhanced ICP/MAP values, insulin receptor-beta and p(S1177) eNOS expressions compared with the MetS group. Discussion and Conclusion MetS caused a deterioration in erectile function accompanied by an increase in resistin expression and a reduction in eNOS enzyme activation in the rat penile tissues. Boldine treatment resulted in an improvement in erectile function, independent of resistin expression.
C1 [Kara, Erkan; Dayar, Ezgi; Gidener, Sedef; Durmus, Nergiz] Dokuz Eylul Univ, Fac Med, Dept Pharmacol, Izmir, Turkey.
   [Kahraman, Erkan; Atabey, Nese] Izmir Biomed & Genome Ctr, Izmir, Turkey.
   [Anacak, Gunay Yetik] Ege Univ, Fac Parmacy, Dept Pharmacol, Izmir, Turkey.
   [Demir, Omer] Dokuz Eylul Univ, Fac Med, Dept Urol, Izmir, Turkey.
C3 Dokuz Eylul University; Izmir Biomedicine & Genome Center; Ege
   University; Dokuz Eylul University
RP Durmus, N (corresponding author), Dokuz Eylul Univ, Fac Med, Dept Pharmacol, Izmir, Turkey.
EM nergiz.durmus@deu.edu.tr
RI Şaman, Ezgi/GRO-3500-2022; gidener, sedef/NJS-8676-2025; Kahraman,
   Erkan/AAE-6696-2019; Yetik Anacak, Gunay/A-1418-2018; Atabey,
   Nese/A-1853-2018; Durmus, Nergiz/KAM-1185-2024
OI Yetik Anacak, Gunay/0000-0002-7788-1657; Atabey,
   Nese/0000-0003-4966-2980; Saman, Ezgi/0000-0001-5567-1408; Durmus,
   Nergiz/0000-0003-4739-9154; Kahraman, Erkan/0000-0003-0051-416X;
   GIDENER, SEDEF/0000-0002-5182-9789
FU Scientific and Technological Research Council of Turkey [114S792]
FX Scientific and Technological Research Council of Turkey, Grant/Award
   Number: 114S792
CR Amidu N, 2013, DIABETOL METAB SYNDR, V5, DOI 10.1186/1758-5996-5-42
   Asencio M, 1999, PHARMACOL BIOCHEM BE, V62, P7, DOI 10.1016/S0091-3057(98)00096-3
   Aslan Y, 2014, AGING MALE, V17, P76, DOI 10.3109/13685538.2014.895318
   Baena M, 2016, SCI REP-UK, V6, DOI 10.1038/srep26149
   Barnes KM, 2009, CURR PROTEIN PEPT SC, V10, P96, DOI 10.2174/138920309787315239
   Burnett MS, 2005, ATHEROSCLEROSIS, V182, P241, DOI 10.1016/j.atherosclerosis.2005.02.014
   Castro GSF, 2011, ACTA CIR BRAS, V26, P45, DOI 10.1590/S0102-86502011000800009
   Chen CY, 2010, AM J PHYSIOL-HEART C, V299, pH193, DOI 10.1152/ajpheart.00431.2009
   Costa IC, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/107869
   Cozma Angela, 2009, Rom J Intern Med, V47, P133
   Demir O, 2010, UROL INT, V85, P112, DOI 10.1159/000296286
   Demir T, 2006, INT J UROL, V13, P385, DOI 10.1111/j.1442-2042.2006.01310.x
   Deng YF, 2010, ANN NY ACAD SCI, V1212, pE1, DOI 10.1111/j.1749-6632.2010.05875.x
   Derosa G, 2015, DIABETES RES CLIN PR, V108, P329, DOI 10.1016/j.diabres.2015.01.037
   Ding QX, 2011, TRENDS CARDIOVAS MED, V21, P20, DOI 10.1016/j.tcm.2012.01.004
   Esposito K, 2005, DIABETES CARE, V28, P1201, DOI 10.2337/diacare.28.5.1201
   Geng FH, 2016, BRIT J PHARMACOL, V173, P1569, DOI 10.1111/bph.13466
   Gentile MT, 2008, DIABETES, V57, P577, DOI 10.2337/db07-0557
   Hernández-Salinas R, 2013, J DIABETES RES, V2013, DOI 10.1155/2013/593672
   Jang YY, 2000, PHARMACOL RES, V42, P361, DOI 10.1006/phrs.2000.0705
   Kim SD, 2013, ASIAN J ANDROL, V15, P395, DOI 10.1038/aja.2012.159
   Kougias P, 2005, J VASC SURG, V41, P691, DOI 10.1016/j.jvs.2004.12.046
   Lau YS, 2013, BRIT J PHARMACOL, V170, P1190, DOI 10.1111/bph.12350
   Lau YS, 2013, BIOCHEM PHARMACOL, V85, P367, DOI 10.1016/j.bcp.2012.11.010
   Lau YS, 2012, EXP BIOL MED, V237, P93, DOI 10.1258/ebm.2011.011145
   Li R, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-12907-1
   Mather K, 2001, J VASC RES, V38, P415, DOI 10.1159/000051074
   Murat N, 2016, J SEX MED, V13, P12, DOI 10.1016/j.jsxm.2015.12.002
   Musicki B, 2009, J ANDROL, V30, P352, DOI 10.2164/jandrol.108.006999
   Nakamura K, 2014, J CARDIOL, V63, P250, DOI 10.1016/j.jjcc.2013.11.006
   O'Brien P, 2006, CHEM-BIOL INTERACT, V159, P1, DOI 10.1016/j.cbi.2005.09.002
   Palanivel R, 2006, DIABETOLOGIA, V49, P183, DOI 10.1007/s00125-005-0060-z
   Pereira RM, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040405
   Riedner CE, 2006, J UROLOGY, V176, P1519, DOI 10.1016/j.juro.2006.06.049
   Rodrigues FL, 2015, CURR DRUG TARGETS, V16, P442, DOI 10.2174/1389450116666150420145757
   Silva FH, 2013, J SEX MED, V10, P960, DOI 10.1111/jsm.12063
   Steppan CM, 2001, NATURE, V409, P307, DOI 10.1038/35053000
   TAKEISHI Y, 2013, J CARDIOVASC DIS DIA, V1, P122, DOI DOI 10.4172/2329-9517.1000122
   Tappy L, 2010, NUTRITION, V26, P1044, DOI 10.1016/j.nut.2010.02.014
   Ukkola O, 2002, EUR J ENDOCRINOL, V147, P571, DOI 10.1530/eje.0.1470571
   Vlachopoulos C, 2007, EUR UROL, V52, P1590, DOI 10.1016/j.eururo.2007.08.004
   Yang XY, 2018, PLANTA MED, V84, P20, DOI 10.1055/s-0043-113447
   Yetik-Anacak G, 2015, BRIT J PHARMACOL, V172, P1434, DOI 10.1111/bph.12700
   YU SM, 1994, N-S ARCH PHARMACOL, V349, P637, DOI 10.1007/BF01258470
   ZETLER G, 1988, ARCH INT PHARMACOD T, V296, P255
NR 45
TC 9
Z9 10
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-2919
EI 2047-2927
J9 ANDROLOGY-US
JI Andrology
PD NOV
PY 2020
VL 8
IS 6
BP 1728
EP 1735
DI 10.1111/andr.12853
EA AUG 2020
PG 8
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ON9KM
UT WOS:000555688800001
PM 32609430
OA Bronze
DA 2025-06-11
ER

PT J
AU Buquicchio, R
   Foti, C
   Loconsole, F
   Polimeno, L
   Ventura, MT
AF Buquicchio, R.
   Foti, C.
   Loconsole, F.
   Polimeno, L.
   Ventura, M. T.
TI CLUSTERIN SERUM LEVEL: HOW DOES IT AFFECT PSORIATIC PATIENTS?
SO JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
LA English
DT Article
DE clusterin; metabolic syndrome; psoriasis
ID KAPPA-B; PROTEIN; DISEASE
AB Psoriasis is a chronic inflammatory skin disease with systemic involvement that might predispose to many psoriasis-related comorbidities, such as metabolic syndrome and cardiovascular disorders. Clusterin (Clu), also known as apolipoprotein J (ApoJ), is a highly conserved disulfide-linked heterodimeric glycoprotein implicated in a great variety of physiological and pathophysiological processes including lipid transportation, tissue remodeling, senescence, cell interaction, stress response, inflammation, apoptosis, diabetes mellitus and metabolic syndrome. Serum levels of Clu were assessed in 15 patients with moderate-to-severe psoriasis defined by the presence of a Psoriasis Area and a Severity Index (PASI) value of 10 or more. It was found that the Clu value was significantly higher in patients than in healthy subjects (p <0.001). Our data confirm that the association of psoriatic disease with some comorbidities, especially metabolic and cardiovascular disease, might support the correlation with increased circulating Clu. In particular, it should be pointed out that, according to the recent literature, the Clu could also have a protective role in the comorbidity of psoriasis patients. In addition, it has been published that Clu protects cardiomyocytes against ischemic cell death and is a potential therapeutic agent in the treatment of myocardial infarction; therefore it can be assumed that an artificial enhancement of Clu in the blood could limit the severity of damage also in respect to skin lesions. Although the increase in serum level of Clu was found in all patients with psoriasis, more studies on a larger cohort of patient samples is necessary to confirm the significance of high serum levels of clusterin/ApoJ and to suggest the use of this glycoprotein as an additional new marker in psoriasis pathogenesis. It could be a possibility to improve the prognosis in patients with psoriasis.
C1 [Buquicchio, R.; Foti, C.; Loconsole, F.] Univ Bari, Sch Med, Dept Biomed Sci & Human Oncol, Dermatol Clin, Bari, Italy.
   [Polimeno, L.] Univ Bari, Sch Med, Dept Interdisciplinary Med, Sect Sci & Technol Lab Med, Bari, Italy.
   [Ventura, M. T.] Univ Bari, Sch Med, Dept Interdisciplinary Med, Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro; Universita degli Studi di Bari Aldo Moro
RP Ventura, MT (corresponding author), Univ Bari, Dept Interdisciplinary Med, Piazza G Cesare 11, I-70124 Bari, Italy.
EM mariateresa.ventura@uniba.it
RI Ventura, Maria/J-8197-2017; buquicchio, rosalba/AAB-9911-2022
OI LOCONSOLE, Francesco/0000-0003-2852-9451; VENTURA, Maria
   Teresa/0000-0002-2637-4583
CR Aronis KN, 2011, METABOLISM, V60, P747, DOI 10.1016/j.metabol.2010.12.013
   Ataseven A, 2014, DIS MARKERS, V2014, DOI 10.1155/2014/541709
   Boehncke WH, 2015, LANCET, V386, P983, DOI 10.1016/S0140-6736(14)61909-7
   Cassano N, 2008, J BIOL REG HOMEOS AG, V22, P207
   Dey AK, 2017, JAMA CARDIOL
   Falgarone G, 2009, ADV CANCER RES, V104, P139, DOI 10.1016/S0065-230X(09)04008-1
   Jabbari A, 2011, GIORN ITAL DERMAT V, V146, P17
   Kurylowicz A, 2008, ACTA BIOCHIM POL, V55, P629
   Lee JY, 2016, ONCOTARGET, V7, P18541, DOI 10.18632/oncotarget.8105
   Newkirk MM, 1999, J RHEUMATOL, V26, P597
   Santilli G, 2003, J BIOL CHEM, V278, P38214, DOI 10.1074/jbc.C300252200
   Trougakos IP, 2002, INT J BIOCHEM CELL B, V34, P1430, DOI 10.1016/S1357-2725(02)00041-9
   van Dijk A, 2010, EUR J CLIN INVEST, V40, P893, DOI 10.1111/j.1365-2362.2010.02345.x
   Vena GA, 2010, DERMATOL THER, V23, P144, DOI 10.1111/j.1529-8019.2010.01308.x
   Zhang YF, 2015, CELL PHYSIOL BIOCHEM, V36, P1890, DOI 10.1159/000430158
NR 15
TC 8
Z9 8
U1 0
U2 3
PU BIOLIFE SAS
PI SILVA MARINA (TE)
PA VIA S STEFANO 39 BIS, 64029 SILVA MARINA (TE), ITALY
SN 0393-974X
EI 1724-6083
J9 J BIOL REG HOMEOS AG
JI J. Biol. Regul. Homeost. Agents
PD JUL-SEP
PY 2017
VL 31
IS 3
BP 785
EP 789
PG 5
WC Endocrinology & Metabolism; Immunology; Medicine, Research &
   Experimental; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Research & Experimental
   Medicine; Physiology
GA FJ4EE
UT WOS:000412687500034
PM 28958138
DA 2025-06-11
ER

PT J
AU Zawieja, SD
   Gasheva, O
   Zawieja, DC
   Muthuchamy, M
AF Zawieja, Scott D.
   Gasheva, Olga
   Zawieja, David C.
   Muthuchamy, Mariappan
TI Blunted flow-mediated responses and diminished nitric oxide synthase
   expression in lymphatic thoracic ducts of a rat model of metabolic
   syndrome
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE metabolic syndrome; lymphatic vessel contraction; lymph flow; nitric
   oxide synthase; lymphatic endothelial cells
ID ENDOTHELIUM-DEPENDENT RELAXATION; MASSIVE LOCALIZED LYMPHEDEMA;
   INCREASED OXIDATIVE STRESS; MESENTERIC LYMPHATICS; INSULIN-RESISTANCE;
   CONTRACTILE ACTIVITY; VESSELS; OBESITY; PUMP; INFLAMMATION
AB Shear-dependent inhibition of lymphatic thoracic duct (TD) contractility is principally mediated by nitric oxide (NO). Endothelial dysfunction and poor NO bioavailability are hallmarks of vasculature dysfunction in states of insulin resistance and metabolic syndrome (MetSyn). We tested the hypothesis that flow-dependent regulation of lymphatic contractility is impaired under conditions of MetSyn. We utilized a 7-wk high-fructose-fed male Sprague-Dawley rat model of MetSyn and determined the stretch-and flow-dependent contractile responses in an isobaric ex vivo TD preparation. TD diameters were tracked and contractile parameters were determined in response to different transmural pressures, imposed flow, exogenous NO stimulation by S-nitro-N-acetylpenicillamine (SNAP), and inhibition of NO synthase (NOS) by L-nitro-arginine methyl ester (L-NAME) and the reactive oxygen species (ROS) scavenging molecule 4-hydroxytempo (tempol). Expression of endothelial NO synthase (eNOS) in TD was determined using Western blot. Approximately 25% of the normal flow-mediated inhibition of contraction frequency was lost in TDs isolated from MetSyn rats despite a comparable SNAP response. Inhibition of NOS with L-NAME abolished the differences in the shear-dependent contraction frequency regulation between control and MetSyn TDs, whereas tempol did not restore the flow responses in MetSyn TDs. We found a significant reduction in eNOS expression in MetSyn TDs suggesting that diminished NO production is partially responsible for impaired flow response. Thus our data provide the first evidence that MetSyn conditions diminish eNOS expression in TD endothelium, thereby affecting the flow-mediated changes in TD lymphatic function.
C1 [Zawieja, Scott D.; Gasheva, Olga; Zawieja, David C.; Muthuchamy, Mariappan] Texas A&M Univ, Texas A&M Hlth Sci Ctr, Div Lymphat Biol, Dept Med Physiol,Coll Med,Cardiovasc Res Inst, 702 SW HK Dodgen Loop, Temple, TX 76504 USA.
C3 Texas A&M University System; Texas A&M University College Station; Texas
   A&M Health Science Center
RP Muthuchamy, M (corresponding author), Texas A&M Univ, Texas A&M Hlth Sci Ctr, Div Lymphat Biol, Dept Med Physiol,Coll Med,Cardiovasc Res Inst, 702 SW HK Dodgen Loop, Temple, TX 76504 USA.
EM marim@tamu.edu
OI Zawieja, David/0000-0002-2644-6524
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [R01-DK-99221]
FX This work was supported by National Institute of Diabetes and Digestive
   and Kidney Diseases Grant R01-DK-99221 (to M. Muthuchamy and D. C.
   Zawieja).
CR Ahmed RL, 2011, BREAST CANCER RES TR, V130, P981, DOI 10.1007/s10549-011-1667-z
   Akl TJ, 2011, AM J PHYSIOL-HEART C, V301, pH1828, DOI 10.1152/ajpheart.00538.2011
   Asch S, 2008, J AM ACAD DERMATOL, V59, pS109, DOI 10.1016/j.jaad.2008.04.009
   Avraham T, 2013, FASEB J, V27, P1114, DOI 10.1096/fj.12-222695
   BENOIT JN, 1989, AM J PHYSIOL, V257, pH2059, DOI 10.1152/ajpheart.1989.257.6.H2059
   Bigazzi R, 2007, J NEPHROL, V20, P10
   Blum KS, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094713
   Bohlen HG, 2011, AM J PHYSIOL-HEART C, V301, pH1897, DOI 10.1152/ajpheart.00260.2011
   Bohlen HG, 2009, AM J PHYSIOL-HEART C, V297, pH1319, DOI 10.1152/ajpheart.00039.2009
   Chopra K, 2015, ANN PLAS SURG, V74, P126, DOI 10.1097/SAP.0b013e31828bb332
   Cozma Angela, 2009, Rom J Intern Med, V47, P133
   Davis MJ, 2005, MICROCIRCULATION, V12, P361, DOI 10.1080/10739680590934772
   Diamant Michaela, 2006, Curr Diab Rep, V6, P279, DOI 10.1007/s11892-006-0061-4
   Fife C, 2014, OSTOMY WOUND MANAG, V60, P30
   Fleming I, 2003, AM J PHYSIOL-REG I, V284, pR1, DOI 10.1152/ajpregu.00323.2002
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gashev AA, 2004, MICROCIRCULATION, V11, P477, DOI 10.1080/10739680490476033
   Gashev AA, 2002, J PHYSIOL-LONDON, V540, P1023, DOI 10.1113/jphysiol.2002.016642
   Gashev AA, 2008, ANN NY ACAD SCI, V1131, P100, DOI 10.1196/annals.1413.009
   Gasheva OY, 2006, J PHYSIOL-LONDON, V575, P821, DOI 10.1113/jphysiol.2006.115212
   Gasheva OY, 2013, J PHYSIOL-LONDON, V591, P4549, DOI 10.1113/jphysiol.2013.258681
   Grundy SM, 2004, J CLIN ENDOCR METAB, V89, P2595, DOI 10.1210/jc.2004-0372
   Hoang HH, 2013, CURR OPIN CLIN NUTR, V16, P76, DOI 10.1097/MCO.0b013e32835ad1ef
   Kim F, 2008, ARTERIOSCL THROM VAS, V28, P1982, DOI 10.1161/ATVBAHA.108.169722
   Kim SK, 2004, AM J CLIN NUTR, V79, P593
   Lee S, 2014, J PHYSIOL-LONDON, V592, P5409, DOI 10.1113/jphysiol.2014.280347
   Lynch LL, 2015, AM J PHYSIOL-HEART C, V308, pH1229, DOI 10.1152/ajpheart.00527.2013
   Marchesi C, 2009, HYPERTENSION, V54, P1384, DOI 10.1161/HYPERTENSIONAHA.109.138305
   Mehrara BJ, 2014, PLAST RECONSTR SURG, V134, p154E, DOI 10.1097/PRS.0000000000000268
   Nizamutdinova IT, 2014, MICROCIRCULATION, V21, P640, DOI 10.1111/micc.12143
   Potenza MA, 2005, AM J PHYSIOL-HEART C, V289, pH813, DOI 10.1152/ajpheart.00092.2005
   Quick CM, 2007, AM J PHYSIOL-REG I, V292, pR1510, DOI 10.1152/ajpregu.00258.2006
   Roberts CK, 2006, METABOLISM, V55, P928, DOI 10.1016/j.metabol.2006.02.022
   Rockson Stanley G, 2012, Curr Treat Options Cardiovasc Med, V14, P184, DOI 10.1007/s11936-012-0170-0
   Savetsky IL, 2014, AM J PHYSIOL-HEART C, V307, pH165, DOI 10.1152/ajpheart.00244.2014
   Scallan JP, 2013, J PHYSIOL-LONDON, V591, P2139, DOI 10.1113/jphysiol.2012.250662
   Shinozaki K, 1999, DIABETES, V48, P2437, DOI 10.2337/diabetes.48.12.2437
   Thangaswamy S, 2012, LYMPHAT RES BIOL, V10, P53, DOI 10.1089/lrb.2011.0022
   Valerio A, 2006, J CLIN INVEST, V116, P2791, DOI [10.1172/JCI28570, 10.1172/JCI28570.]
   von der Weid PY, 2014, LYMPHAT RES BIOL, V12, P66, DOI 10.1089/lrb.2013.0045
   Von Der Weid PY, 2001, ALIMENT PHARM THER, V15, P1115, DOI 10.1046/j.1365-2036.2001.01037.x
   von der Weid PY, 2001, AM J PHYSIOL-HEART C, V280, pH2707, DOI 10.1152/ajpheart.2001.280.6.H2707
   von der Weld PY, 1998, BRIT J PHARMACOL, V125, P17, DOI 10.1038/sj.bjp.0702026
   vonderWeid PY, 1996, J PHYSIOL-LONDON, V493, P563, DOI 10.1113/jphysiol.1996.sp021404
   Weitman ES, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0070703
   Zawieja David C., 2009, Lymphatic Research and Biology, V7, P87, DOI 10.1089/lrb.2009.0007
   ZAWIEJA DC, 1993, LYMPHOLOGY, V26, P135
   ZAWIEJA DC, 1991, AM J PHYSIOL, V260, pH1935, DOI 10.1152/ajpheart.1991.260.6.H1935
   Zawieja SD, 2012, AM J PHYSIOL-HEART C, V302, pH643, DOI 10.1152/ajpheart.00606.2011
NR 49
TC 29
Z9 31
U1 0
U2 6
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD FEB 1
PY 2016
VL 310
IS 3
BP H385
EP H393
DI 10.1152/ajpheart.00664.2015
PG 9
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA DC2PC
UT WOS:000369057600007
PM 26637560
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU El-Bassossy, HM
   Dsokey, N
   Fahmy, A
AF El-Bassossy, Hany M.
   Dsokey, Nora
   Fahmy, Ahmed
TI Characterization of vascular complications in experimental model of
   fructose-induced metabolic syndrome
SO TOXICOLOGY MECHANISMS AND METHODS
LA English
DT Article
DE Aorta; hypertension; metabolic syndrome; vascular reactivity; rat
ID INHIBITION ALLEVIATES HYPERTENSION; INSULIN-RESISTANCE; ENDOTHELIAL
   DYSFUNCTION; DEPENDENT RELAXATION; CARDIOVASCULAR RISK; OXIDATIVE
   STRESS; ANGIOTENSIN-II; YOUNG SUBJECTS; RATS; RESPONSES
AB Vascular dysfunction is an important complication associated with metabolic syndrome (MS). Here we fully characterized vascular complications in a rat model of fructose-induced MS. MS was induced by adding fructose (10%) to drinking water to male Wistar rats of 6 weeks age. Blood pressure (BP) and isolated aorta responses phenylephrine (PE), KCl, acetylcholine (ACh), and sodium nitroprusside (SNP) were recorded after 6, 9, and 12 weeks of fructose administration. In addition, serum levels of glucose, insulin, uric acid, tumor necrosis factor a (TNF alpha), lipids, advanced glycation end products (AGEs), and arginase activity were determined. Furthermore, aortic reactive oxygen species (ROS) generation, hemeoxygenase-1 expression, and collagen deposition were examined. Fructose administration resulted in a significant hyperinslinemia after 6 weeks which continued for 12 weeks. It was also associated with a significant increase in BP after 6 weeks which was stable for 12 weeks. Aorta isolated from MS animals showed exaggerated contractility to PE and KCl and impaired relaxation to ACh compared with control after 6 weeks which were clearer at 12 weeks of fructose administration. In addition, MS animals showed significant increases in serum levels of lipids, uric acid, AGEs, TNFa, and arginase enzyme activity after 12 weeks of fructose administration. Furthermore, aortae isolated from MS animals were characterized by increased ROS generation and collagen deposition. In conclusion, adding fructose (10%) to drinking water produces a model of MS with vascular complications after 12 weeks that are characterized by insulin resistance, hypertension, disturbed vascular reactivity and structure, hyperuricemia, dyslipidemia, and low-grade inflammation.
C1 [El-Bassossy, Hany M.] King Abdulaziz Univ, Fac Pharm, Dept Pharmacol, Jeddah 21589, Saudi Arabia.
   [El-Bassossy, Hany M.; Dsokey, Nora; Fahmy, Ahmed] Zagazig Univ, Fac Pharm, Dept Pharmacol, Zagazig, Egypt.
C3 King Abdulaziz University; Egyptian Knowledge Bank (EKB); Zagazig
   University
RP El-Bassossy, HM (corresponding author), King Abdulaziz Univ, Fac Pharm, Dept Pharmacol, POB 80260, Jeddah 21589, Saudi Arabia.
EM helbassossy@kau.edu.sa
RI El-Bassossy, Hany/NKQ-3705-2025; El-Bassossy, Hany/I-1576-2012
OI El-Bassossy, Hany/0000-0002-6838-6945
FU Science and Technology Development Fund, Egypt [ID1024]
FX The authors state that they have no declaration of interest. This work
   is funded by a research Grant ID1024 provided by the Science and
   Technology Development Fund, Egypt.
CR Abraham NG, 2008, PHARMACOL REV, V60, P79, DOI 10.1124/pr.107.07104
   Balletshofer BM, 2003, ATHEROSCLEROSIS, V171, P303, DOI 10.1016/j.atherosclerosis.2003.08.013
   Beckman JS, 1996, CHEM RES TOXICOL, V9, P836, DOI 10.1021/tx9501445
   Berkowitz DE, 2003, CIRCULATION, V108, P2000, DOI 10.1161/01.CIR.0000092948.04444.C7
   Bimenya Gabriel S, 2003, Afr Health Sci, V3, P23
   Bivalacqua TJ, 2001, BIOCHEM BIOPH RES CO, V283, P923, DOI 10.1006/bbrc.2001.4874
   BLAKELY SR, 1981, J NUTR, V111, P307, DOI 10.1093/jn/111.2.307
   Busija DW, 2006, ANTIOXID REDOX SIGN, V8, P1131, DOI 10.1089/ars.2006.8.1131
   Cao J, 2009, INT J BIOCHEM CELL B, V41, P1025, DOI 10.1016/j.biocel.2008.10.025
   Carmassi F, 2005, THROMB RES, V116, P207, DOI 10.1016/j.thromres.2004.11.026
   Chen H, 2006, PHARMACOL RES, V53, P469, DOI 10.1016/j.phrs.2006.03.003
   Cosenzi A, 1999, J HYPERTENS, V17, P1843, DOI 10.1097/00004872-199917121-00010
   DAI S, 1995, J PHARMACOL TOX MET, V33, P101, DOI 10.1016/1056-8719(94)00063-A
   DANIELSEN R, 1987, AM J CARDIOL, V60, P143, DOI 10.1016/0002-9149(87)91001-0
   De Vriese AS, 2000, BRIT J PHARMACOL, V130, P963, DOI 10.1038/sj.bjp.0703393
   Delbosc S, 2005, ATHEROSCLEROSIS, V179, P43, DOI 10.1016/j.atherosclerosis.2004.10.018
   El-Bassossy HM, 2013, BRIT J PHARMACOL, V169, P693, DOI 10.1111/bph.12144
   El-Bassossy HM, 2012, VASC PHARMACOL, V57, P194, DOI 10.1016/j.vph.2012.01.001
   El-Bassossy HM, 2012, CLIN EXP PHARMACOL P, V39, P643, DOI 10.1111/j.1440-1681.2012.05724.x
   El-Bassossy HM, 2011, FOOD CHEM TOXICOL, V49, P3007, DOI 10.1016/j.fct.2011.07.060
   El-Bassossy HM, 2011, N-S ARCH PHARMACOL, V384, P277, DOI 10.1007/s00210-011-0669-z
   Erdös B, 2002, AM J PHYSIOL-HEART C, V282, pH2060, DOI 10.1152/ajpheart.01124.2001
   FERRANNINI E, 1987, NEW ENGL J MED, V317, P350, DOI 10.1056/NEJM198708063170605
   FOSSATI P, 1980, CLIN CHEM, V26, P227
   Fukuyama N, 2008, J CLIN BIOCHEM NUTR, V43, P1, DOI 10.3164/jcbn.2008036
   Gregoire IP, 2006, ATHEROSCLEROSIS SUPP, V7, P198
   HALLFRISCH J, 1983, J NUTR, V113, P1819, DOI 10.1093/jn/113.9.1819
   Hassan N, 2013, N-S ARCH PHARMACOL, V386, P217, DOI 10.1007/s00210-012-0822-3
   HWANG IS, 1987, HYPERTENSION, V10, P512, DOI 10.1161/01.HYP.10.5.512
   Iyer SN, 1996, CLIN EXP HYPERTENS, V18, P227, DOI 10.3109/10641969609081766
   Katakam PVG, 1998, AM J PHYSIOL-REG I, V275, pR788, DOI 10.1152/ajpregu.1998.275.3.R788
   Lakka HM, 2000, ARCH INTERN MED, V160, P1160, DOI 10.1001/archinte.160.8.1160
   Mahmoud MF, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0063784
   Marks JB, 2000, J DIABETES COMPLICAT, V14, P108, DOI 10.1016/S1056-8727(00)00065-9
   McKendrick JD, 1998, BRIT J PHARMACOL, V124, P361, DOI 10.1038/sj.bjp.0701829
   NAGELE U, 1984, J CLIN CHEM CLIN BIO, V22, P165
   Nisoli E, 2007, CIRC RES, V100, P795, DOI 10.1161/01.RES.0000259591.97107.6c
   Pedersen TR, 1998, AM J CARDIOL, V82, p53T
   REAVEN GM, 1991, AM J MED, V90, pS7, DOI 10.1016/0002-9343(91)90028-V
   Roberts CK, 2000, HYPERTENSION, V36, P423, DOI 10.1161/01.HYP.36.3.423
   Robins SJ, 2001, AM J CARDIOL, V88, p19N
   Romero MJ, 2008, CIRC RES, V102, P95, DOI 10.1161/CIRCRESAHA.107.155028
   Sampathkumar R, 2005, METABOLISM, V54, P1002, DOI 10.1016/j.metabol.2005.02.017
   Shinozaki K, 2004, HYPERTENSION, V43, P255, DOI 10.1161/01.HYP.0000111136.86976.26
   Steinberg HO, 1996, J CLIN INVEST, V97, P2601, DOI 10.1172/JCI118709
   Takagawa Y, 2001, AM J HYPERTENS, V14, P811, DOI 10.1016/S0895-7061(01)01298-5
   Tan HW, 2010, ATHEROSCLEROSIS, V208, P350, DOI 10.1016/j.atherosclerosis.2009.07.053
   TOBEY TA, 1982, METABOLISM, V31, P608, DOI 10.1016/0026-0495(82)90100-7
   Togashi N, 2002, HYPERTENSION, V39, P578, DOI 10.1161/hy0202.103290
   Ugochukwu NH, 2003, CLIN CHIM ACTA, V336, P73, DOI 10.1016/S0009-8981(03)00325-5
   Verma S, 1996, AM J HYPERTENS, V9, P370, DOI 10.1016/0895-7061(95)00392-4
   Viswanad B, 2006, PHARMACOL RES, V53, P209, DOI 10.1016/j.phrs.2005.11.002
   WOLFF SP, 1987, BIOCHEM J, V245, P243, DOI 10.1042/bj2450243
   Zanchetti A, 2001, J HYPERTENS, V19, P1149, DOI 10.1097/00004872-200106000-00021
   ZAVARONI I, 1980, METABOLISM, V29, P970, DOI 10.1016/0026-0495(80)90041-4
NR 55
TC 32
Z9 35
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1537-6516
EI 1537-6524
J9 TOXICOL MECH METHOD
JI Toxicol. Mech. Methods
PD DEC
PY 2014
VL 24
IS 8
BP 536
EP 543
DI 10.3109/15376516.2014.945109
PG 8
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA AS6GU
UT WOS:000344363200002
PM 25046175
DA 2025-06-11
ER

PT J
AU Sengul, C
   Duman, D
AF Sengul, Cihan
   Duman, Dursun
TI The Association of Epicardial Fat Thickness with Blunted Heart Rate
   Recovery in Patients with Metabolic Syndrome
SO TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
LA English
DT Article
DE cardiac stress test; echocardiography; epicardial fat; heart rate
   recovery; metabolic syndrome
ID ENDOTHELIUM-DEPENDENT DILATION; ADIPOSE-TISSUE; SYMPATHETIC ACTIVATION;
   RISK-FACTORS; EXERCISE; DYSFUNCTION; PREDICTOR; EVENTS; VOLUME
AB Epicardial fat tissue has unique endocrine and paracrine functions that affect the cardiac autonomic system. Epicardial fat thickness (EFT) and blunted heart rate recovery (HRR) are newly identified cardiovascular risk factors in patients with metabolic syndrome (MS). The objective of this study is to evaluate the association between EFT and HRR in patients with MS. Forty patients with MS and 36 healthy controls were included in the study. Echocardiographic EFT and HRR at 1min after exercise termination (HRR-1) are measured and compared between the two groups. HRR-1 equal to or lower than 18 beats is considered as blunted HRR. EFT was increased (7.2 +/- 2 vs. 5.6 +/- 1.8 mm; p = 0.001) and HRR-1 was significantly reduced in patients with MS compared to control group (21 +/- 8 vs. 26 +/- 9; p = 0.006). Among the MS patients, subjects with blunted HRR had increased EFT compared to patients without blunted HRR (8.5 +/- 2.0 vs. 5.9 +/- 1.1 mm, p < 0.001). In multivariate analysis, EFT was the only independent predictor of blunted HRR in patients with MS (95% confidence interval = 1.42-3.87, OR = 2.34, p = 0.001). Furthermore, EFT of equal to or thicker than 5.5 mm was associated with the blunted HRR with 84% sensitivity and 52% specificity (ROC area under curve: 0.84, 95% confidence interval = 0.70-0.96, p < 0.001). In conclusion, EFT is an independent predictor of blunted HRR, a novel cardiovascular risk factor, in patients with MS.
C1 [Sengul, Cihan] Goztepe Med Pk Hosp, Dept Cardiol, TR-34220 Istanbul, Turkey.
   [Duman, Dursun] Medipol Univ Med, Dept Cardiol, Istanbul, Turkey.
C3 Medical Park Hospitals Group; Istanbul Medipol University
RP Sengul, C (corresponding author), Goztepe Med Pk Hosp, Dept Cardiol, TR-34220 Istanbul, Turkey.
EM drcsengul@yahoo.com
RI Duman, Dursun/B-5558-2015
CR Aydin H, 2010, METAB SYNDR RELAT D, V8, P229, DOI 10.1089/met.2009.0080
   Bruun JM, 2003, AM J PHYSIOL-ENDOC M, V285, pE527, DOI 10.1152/ajpendo.00110.2003
   CELERMAJER DS, 1994, J AM COLL CARDIOL, V24, P1468, DOI 10.1016/0735-1097(94)90141-4
   Cole CR, 1999, NEW ENGL J MED, V341, P1351, DOI 10.1056/NEJM199910283411804
   Dick GM, 2006, AM J PHYSIOL-HEART C, V291, pH2997, DOI 10.1152/ajpheart.01035.2005
   Gastaldelli A, 2010, NUTR METAB CARDIOVAS, V20, P481, DOI 10.1016/j.numecd.2010.05.005
   Gulati M, 2003, CIRCULATION, V108, P1554, DOI 10.1161/01.CIR.0000091080.57509.E9
   Hijmering ML, 2002, J AM COLL CARDIOL, V39, P683, DOI 10.1016/S0735-1097(01)01786-7
   Huang PH, 2004, AM J CARDIOL, V93, P10, DOI 10.1016/j.amjcard.2003.09.004
   Iacobellis G, 2005, NAT CLIN PRACT CARD, V2, P536, DOI 10.1038/ncpcardio0319
   Iacobellis G, 2005, CYTOKINE, V29, P251, DOI 10.1016/j.cyto.2004.11.002
   Iacobellis G, 2003, J CLIN ENDOCR METAB, V88, P5163, DOI 10.1210/jc.2003-030698
   IMAI K, 1994, J AM COLL CARDIOL, V24, P1529, DOI 10.1016/0735-1097(94)90150-3
   Lang RM, 2005, J AM SOC ECHOCARDIOG, V18, P1440, DOI 10.1016/j.echo.2005.10.005
   Lind L, 2002, AM HEART J, V144, P666, DOI 10.1067/mhj.2002.124836
   Manfrini O, 2003, EUR HEART J, V24, P1560, DOI 10.1016/S0195-668X(03)00345-2
   Manzella D, 2001, J CLIN ENDOCR METAB, V86, P2769, DOI 10.1210/jc.86.6.2769
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Straznicky NE, 2008, CURR HYPERTENS REP, V10, P440, DOI 10.1007/s11906-008-0083-1
   Tan KCB, 2004, J CLIN ENDOCR METAB, V89, P765, DOI 10.1210/jc.2003-031012
   Tartan Z, 2006, TOHOKU J EXP MED, V210, P57, DOI 10.1620/tjem.210.57
   Thomson RL, 2010, FERTIL STERIL, V93, P1173, DOI 10.1016/j.fertnstert.2008.12.003
   Tsuji H, 1996, CIRCULATION, V94, P2850, DOI 10.1161/01.CIR.94.11.2850
   Ueno K, 2009, CIRC J, V73, P1927, DOI 10.1253/circj.CJ-09-0266
   van de Borne P, 1999, AM J PHYSIOL-REG I, V276, pR178, DOI 10.1152/ajpregu.1999.276.1.R178
   Wang CP, 2009, CLIN ENDOCRINOL, V70, P876, DOI 10.1111/j.1365-2265.2008.03411.x
   Watanabe J, 2001, CIRCULATION, V104, P1911, DOI 10.1161/circ.104.16.1911
NR 27
TC 22
Z9 22
U1 0
U2 0
PU TOHOKU UNIV MEDICAL PRESS
PI SENDAI
PA 2-1, SEIRYO-MACHI, AOBA-KU, SENDAI, MIYAGI 980-8575, JAPAN
SN 0040-8727
EI 1349-3329
J9 TOHOKU J EXP MED
JI Tohoku J. Exp. Med.
PD AUG
PY 2011
VL 224
IS 4
BP 257
EP 262
DI 10.1620/tjem.224.257
PG 6
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 812ED
UT WOS:000294273000003
PM 21737994
OA Bronze
DA 2025-06-11
ER

PT J
AU Kawamoto, R
   Kohara, K
   Tabara, Y
   Miki, T
   Otsuka, N
AF Kawamoto, Ryuichi
   Kohara, Katsuhiko
   Tabara, Yasuharu
   Miki, Tetsuro
   Otsuka, Nobuyuki
TI Serum Gamma-Glutamyl Transferase Levels are Associated with Metabolic
   Syndrome in Community-Dwelling Individuals
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Article
DE Gamma-glutamyl transferase; Metabolic syndrome; Risk factor; Insulin
   resistance
ID MIDDLE-AGED MEN; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   TRANSPEPTIDASE; RISK; ATHEROSCLEROSIS; PREDICTOR; HYPERTENSION;
   MORTALITY; OXIDATION
AB Aim: Serum gamma-glutamyl transferase (GGT) activity changes in response to oxidative stress. Metabolic syndrome (MetS) is associated with an increased risk of major cardiovascular events. Few data are available on the association between serum GGT and the prevalence of MetS among community-dwelling individuals in Japan.
   Methods: We recruited 793 men (mean age, 60 +/- 14 years), and 1,073 women (62 +/- 12 years), free from any history relating to cardiovascular disease during their annual health examination, from a single community. We performed a cross-sectional study to examine whether serum GGT was associated with MetS.
   Results: The levels of most confounding characteristics varied with increasing GGT activity After adjustment for age, smoking status, drinking status, low-density lipoprotein cholesterol, uric acid, estimated glomerular filtration rate and alanine aminotransferase, the odds ratios (95% confidence interval) for MetS increased across serum GGT tertiles (1, 2.23 (1.22-4.07), and 2.32 (1.18-4.56) in men; and 1, 1.43 (0.81-2.51), and 2.64 (1.50-4.64) in women). After additional adjustment for insulin resistance markers (immuno-reactive insulin or homoeostasis model assessment of insulin resistance index), the association was attenuated and the linear relation no longer significant in both genders. Furthermore, serum GGT was significantly associated with the presence of individual components of MetS in both genders, except for dyslipidemia in men and hypertension in women.
   Conclusions: These results suggested that higher serum GGT was significantly associated with MetS and its components in the general population. This association was related with insulin resistance but was independent of other confounding factors.
C1 [Kawamoto, Ryuichi; Otsuka, Nobuyuki] Seiyo Municipal Nomura Hosp, Dept Internal Med, Seiyo City, Ehime 7971212, Japan.
   [Kohara, Katsuhiko; Tabara, Yasuharu; Miki, Tetsuro] Ehime Univ, Sch Med, Dept Geriatr Med, Matsuyama, Ehime 790, Japan.
C3 Ehime University
RP Kawamoto, R (corresponding author), Seiyo Municipal Nomura Hosp, Dept Internal Med, 9-53 Nomura,Nomura Cho, Seiyo City, Ehime 7971212, Japan.
EM rykawamo@yahoo.co.jp
FU Foundation for the Development of Community
FX This work was supported in part by a grant-in-aid from the Foundation
   for the Development of Community (2008).
CR André P, 2006, DIABETOLOGIA, V49, P2599, DOI 10.1007/s00125-006-0418-x
   André P, 2007, DIABETES CARE, V30, P2355, DOI 10.2337/dc07-0440
   [Anonymous], 2005, Nihon Naika Gakkai Zasshi, V94, P794
   Emdin M, 2005, CIRCULATION, V112, P2078, DOI 10.1161/CIRCULATIONAHA.105.571919
   Fain JN, 2006, VITAM HORM, V74, P443, DOI 10.1016/S0083-6729(06)74018-3
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Hotamisligil GS, 2003, INT J OBESITY, V27, pS53, DOI 10.1038/sj.ijo.0802502
   IKAI E, 1994, J HUM HYPERTENS, V8, P95
   INOUE K, 1995, LIVER, V15, P70
   *JAP SOC NEPHR, JAP VERS GFR EST
   Kang YH, 2007, DIABETES RES CLIN PR, V77, P306, DOI 10.1016/j.diabres.2006.11.009
   Karp DR, 2001, J BIOL CHEM, V276, P3798, DOI 10.1074/jbc.M008484200
   Kawamoto R, 2007, INTERNAL MED, V46, P1771, DOI 10.2169/internalmedicine.46.0261
   KEKEUCHI H, 2003, J JAPAN DIAB SOC, V46, P739
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lee DH, 2004, J HUM HYPERTENS, V18, P803, DOI 10.1038/sj.jhh.1001742
   Lee DH, 2003, CLIN CHEM, V49, P1358, DOI 10.1373/49.8.1358
   Lee DS, 2007, ARTERIOSCL THROM VAS, V27, P127, DOI 10.1161/01.ATV.0000251993.20372.40
   Lee DH, 2006, EUR HEART J, V27, P2170, DOI 10.1093/eurheartj/ehl086
   Lorenzo C, 2003, DIABETES CARE, V26, P3153, DOI 10.2337/diacare.26.11.3153
   Matsuzawa Y, 2002, CIRC J, V66, P987, DOI 10.1253/circj.66.987
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McNeill AM, 2005, DIABETES CARE, V28, P385, DOI 10.2337/diacare.28.2.385
   Meisinger C, 2006, ATHEROSCLEROSIS, V189, P297, DOI 10.1016/j.atherosclerosis.2006.01.010
   Nakanishi N, 2004, DIABETES CARE, V27, P1427, DOI 10.2337/diacare.27.6.1427
   NILSSEN O, 1994, AM J EPIDEMIOL, V139, P787, DOI 10.1093/oxfordjournals.aje.a117075
   Ota T, 2002, DIABETES CARE, V25, P1252, DOI 10.2337/diacare.25.7.1252
   Paolicchi A, 1999, J INVEST MED, V47, P151
   Poikolainen K, 1997, AM J EPIDEMIOL, V146, P1019, DOI 10.1093/oxfordjournals.aje.a009230
   Rantala AO, 2000, J INTERN MED, V248, P230, DOI 10.1046/j.1365-2796.2000.00723.x
   Sakugawa H, 2004, WORLD J GASTROENTERO, V10, P1052
   Shankar A, 2008, ATHEROSCLEROSIS, V199, P102, DOI 10.1016/j.atherosclerosis.2007.10.009
   Shankar A, 2007, CIRC J, V71, P1567, DOI 10.1253/circj.71.1567
   Shiwaku K, 2005, J OCCUP HEALTH, V47, P126, DOI 10.1539/joh.47.126
   Whitfield JB, 2001, CRIT REV CL LAB SCI, V38, P263, DOI 10.1080/20014091084227
NR 35
TC 30
Z9 32
U1 0
U2 5
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PY 2009
VL 16
IS 4
BP 355
EP 362
DI 10.5551/jat.No414
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 493RF
UT WOS:000269754900006
PM 19755788
OA hybrid
DA 2025-06-11
ER

PT J
AU Ueba, T
   Haze, T
   Sugiyama, M
   Higuchi, M
   Asayama, H
   Karitani, Y
   Nishikawa, T
   Yamashita, K
   Nagami, S
   Nakayama, T
   Kanatani, K
   Nomura, S
AF Ueba, Tetsuya
   Haze, Takane
   Sugiyama, Masaki
   Higuchi, Mami
   Asayama, Hitoshi
   Karitani, Yoshihiro
   Nishikawa, Tomofumi
   Yamashita, Kohsuke
   Nagami, Shuhei
   Nakayama, Takeo
   Kanatani, Kazushi
   Nomura, Shosaku
TI Level, distribution and correlates of platelet-derived microparticles in
   healthy individuals with special reference to the metabolic syndrome
SO THROMBOSIS AND HAEMOSTASIS
LA English
DT Article
DE atherothrombosis; platelet-derived microparticle; metabolic syndrome
ID TRANSIENT ISCHEMIC ATTACKS; REMNANT-LIKE PARTICLE; HIGH-SHEAR-STRESS;
   ENDOTHELIAL MICROPARTICLES; CELLULAR MICROPARTICLES;
   CARDIOVASCULAR-DISEASE; HYPERTENSIVE PATIENTS; PROCOAGULANT ACTIVITY;
   ENZYME-IMMUNOASSAY; ACTIVATION
AB Platelet-derived microparticles (PDMPs), a procoagulant factor, are reportedly elevated in type 2 diabetes mellitus and acute coronary syndrome. The metabolic syndrome (MS) is strongly associated with cardio- and cerebrovascular disease-related atherothrombotic events. To clarify the level, distribution and correlates of PDMPs with special reference to MS, we conducted a cross-sectional study of 467 healthy Japanese volunteers without signs, symptoms, or a history of cardio- or cerebrovascular disease. They were 211 men and 256 women (median age 39 and 35 years, respectively). Using an ELISA kit and monoclonal antibodies against CD42b and CD42a (glycoprotein Ib and IX) we assayed the PDMP levels. Total cholesterol, low-density and high-density lipoprotein cholesterol, remnant cholesterol, triglycerides,C-reactive protein, and traditional cardiovascular risk factors were also recorded. There was a significant difference in the level of PDMPs between men and women. The median value and the interquartile range of PDMPs was 8.3 IU/ml and 6.2 - 10.5 IU/ml and 6.8 IU/ml and 5.2 - 8.6 IU/ml, respectively, in men and women. PDMPs were significantly associated with MS criteria in men (p < 0.001) and women (p=0.040). Logistic regression analysis revealed a significant odds ratio of 3.9 [95% confidence interval (0): 1.4-10.5] in men and of 4.2 [95% CI: 1.6-10.71 in the entire study population. Our results suggest that PDMPs identified by glycoprotein CD42b and CD42a are positively associated with MS.
C1 [Ueba, Tetsuya; Nishikawa, Tomofumi; Yamashita, Kohsuke] Kishiwada City Hosp, Dept Neurosurg, Kishiwada 5968501, Japan.
   [Haze, Takane; Sugiyama, Masaki; Higuchi, Mami; Asayama, Hitoshi] Kishiwada City Hosp, Dept Clin Lab, Kishiwada 5968501, Japan.
   [Karitani, Yoshihiro] Kishiwada City Hosp, Dept Pharm, Kishiwada 5968501, Japan.
   [Nagami, Shuhei] Kishiwada City Hosp, Dept Neurol, Kishiwada 5968501, Japan.
   [Nomura, Shosaku] Kishiwada City Hosp, Dept Hematol, Kishiwada 5968501, Japan.
   [Nakayama, Takeo] Kyoto Univ, Sch Publ Hlth, Dept Hlth Informat, Kyoto, Japan.
   [Kanatani, Kazushi] JIMRO Co Ltd, Diagnost Revis, Gunma, Japan.
C3 Kyoto University
RP Ueba, T (corresponding author), Kishiwada City Hosp, Dept Neurosurg, 1001 Gakuharachou, Kishiwada 5968501, Japan.
EM tueba@kuhp.kyoto-u.ac.jp
RI Ueba, Tetsuya/AFL-6434-2022; NAKAYAMA, Takeo/HCH-0537-2022
OI Nakayama, Takeo/0000-0002-7918-6252
CR Arteaga RB, 2006, AM J CARDIOL, V98, P70, DOI 10.1016/j.amjcard.2006.01.054
   Chironi G, 2006, ARTERIOSCL THROM VAS, V26, P2775, DOI 10.1161/01.ATV.0000249639.36915.04
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Devaraj S, 2004, ENDOCRIN METAB CLIN, V33, P431, DOI 10.1016/j.ecl.2004.03.008
   Diamant M, 2004, EUR J CLIN INVEST, V34, P392, DOI 10.1111/j.1365-2362.2004.01355.x
   Diamant M, 2002, CIRCULATION, V106, P2442, DOI 10.1161/01.CIR.0000036596.59665.C6
   Diamant Michaela, 2006, Curr Diab Rep, V6, P279, DOI 10.1007/s11892-006-0061-4
   Esposito K, 2006, ARTERIOSCL THROM VAS, V26, P1926, DOI 10.1161/01.ATV.0000231512.15115.25
   Freyssinet JM, 2003, J THROMB HAEMOST, V1, P1655, DOI 10.1046/j.1538-7836.2003.00309.x
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Henn V, 1998, NATURE, V391, P591, DOI 10.1038/35393
   Hodis HN, 1999, CIRCULATION, V99, P2852, DOI 10.1161/01.CIR.99.22.2852
   Holme PA, 1997, ARTERIOSCL THROM VAS, V17, P646, DOI 10.1161/01.ATV.17.4.646
   Ishikawa S, 2007, CIRC J, V71, P26, DOI 10.1253/circj.71.26
   KANATANI K, 2007, JPN J THROMB HEMOSTA, V18, P653
   LEE YJ, 1993, THROMB RES, V72, P295, DOI 10.1016/0049-3848(93)90138-E
   Mause SF, 2005, ARTERIOSCL THROM VAS, V25, P1512, DOI 10.1161/01.ATV.0000170133.43608.37
   Miyauchi K, 2005, CLIN CHEM, V51, pA129
   Miyazaki Y, 1996, BLOOD, V88, P3456, DOI 10.1182/blood.V88.9.3456.bloodjournal8893456
   Namba M, 2007, ARTERIOSCL THROM VAS, V27, P255, DOI 10.1161/01.ATV.0000252064.97632.2c
   Nomura S, 2001, INT J HEMATOL, V74, P397, DOI 10.1007/BF02982082
   Nomura S, 2002, J HUM HYPERTENS, V16, P539, DOI 10.1038/sj.jhh.1001447
   Nomura S, 2005, THROMB RES, V115, P277, DOI 10.1016/j.thromres.2004.08.015
   Nomura S, 2005, J THROMB THROMBOLYS, V18, P177, DOI 10.1007/s11239-005-0343-8
   NOMURA S, 1995, ATHEROSCLEROSIS, V116, P235, DOI 10.1016/0021-9150(95)05551-7
   Nomura S, 2001, ATHEROSCLEROSIS, V158, P277, DOI 10.1016/S0021-9150(01)00433-6
   Nomura S, 2003, THROMB HAEMOSTASIS, V89, P506
   Ogura H, 2001, J TRAUMA, V50, P801, DOI 10.1097/00005373-200105000-00005
   Osumi K, 2001, THROMB HAEMOSTASIS, V85, P326, DOI 10.1055/s-0037-1615688
   PAMUK GE, 2007, PLATELETS, V23, P1
   Ray DM, 2008, THROMB HAEMOSTASIS, V99, P86, DOI 10.1160/TH07-05-0328
   Reininger AJ, 2006, BLOOD, V107, P3537, DOI 10.1182/blood-2005-02-0618
   Satoh A, 2005, DIABETES CARE, V28, P2514, DOI 10.2337/diacare.28.10.2514
   Sinauridze EI, 2007, THROMB HAEMOSTASIS, V97, P425, DOI 10.1160/TH06-06-0313
   Straub A, 2007, THROMB HAEMOSTASIS, V97, P608, DOI 10.1160/TH06-10-0563
   Van der Zee PM, 2006, CLIN CHEM, V52, P657, DOI 10.1373/clinchem.2005.057414
   Vidal C, 2001, THROMB HAEMOSTASIS, V86, P784, DOI 10.1055/s-0037-1616132
   Vinik AI, 2001, DIABETES CARE, V24, P1476, DOI 10.2337/diacare.24.8.1476
   Weber AA, 2000, THROMB RES, V98, P461, DOI 10.1016/S0049-3848(00)00192-4
   Whicher J, 2001, CLIN CHEM LAB MED, V39, P1054, DOI 10.1515/CCLM.2001.171
   Wiberg B, 2006, STROKE, V37, P2898, DOI 10.1161/01.STR.0000249056.24657.8b
   Yamazaki M, 2005, THROMB RES, V115, P211, DOI 10.1016/j.thromres.2004.08.029
   Zhao XM, 2007, THROMB HAEMOSTASIS, V98, P908, DOI 10.1160/TH06-12-0738
NR 44
TC 55
Z9 58
U1 0
U2 4
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0340-6245
EI 2567-689X
J9 THROMB HAEMOSTASIS
JI Thromb. Haemost.
PD AUG
PY 2008
VL 100
IS 2
BP 280
EP 285
DI 10.1160/TH07-11-0668
PG 6
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 337SL
UT WOS:000258455700018
PM 18690348
DA 2025-06-11
ER

PT J
AU Tsai, JCR
   Sheu, SH
   Chiu, HC
   Chung, FM
   Chang, DM
   Chen, MP
   Shin, SJ
   Lee, YJ
AF Tsai, Jack C. -R.
   Sheu, Sheng-Hsiung
   Chiu, Herng-Chia
   Chung, Fu-Mei
   Chang, Dao-Ming
   Chen, Miao-Pei
   Shin, Shyi-Jang
   Lee, Yau-Jiunn
TI Association of peripheral total and differential leukocyte counts with
   metabolic syndrome and risk of ischemic cardiovascular diseases in
   patients with type 2 diabetes mellitus
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article
DE monocytes; neutrophil; lymphocyte; metabolic syndrome; atherosclerosis
ID BLOOD-CELL COUNT; CORONARY-HEART-DISEASE; LYMPHOCYTE CONCENTRATION;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; GLUCOSE; LEPTIN; ATHEROSCLEROSIS;
   INFLAMMATION; EXPRESSION
AB Background There is increasing evidence that leukocytes play a central role in obesity, glucose intolerance, type 2 diabetes mellitus (T2DM), and cardiovascular diseases, but the role of differential leukocytes in metabolic syndrome (MetS) and atherosclerosis is largely unknown. The aim of this study was to examine the relationship between the component features of MetS and peripheral leukocyte counts and to explore whether leukocyte counts are associated with clustering of MetS and macrovascular diseases in patients with T2DM.
   Methods 1872 subjects with T2DM who enrolled in a diabetes disease management program were studied. The definition of MetS was modified from that outlined by the criteria of NCEP-ATP III. Areas under the receiveroperating characteristic curve and odds ratios at various intervals of the WBC counts were computed.
   Results The peripheral total leukocyte, monocyte, and neutrophil cell counts are increased parallel to the clustering of components of MetS. When white cell counts were analyzed per quartile and as continuous variables after adjustment for age, sex, and other known risk factors with multiple regression analysis, peripheral total leukocyte, monocyte, neutrophils, and lymphocyte counts were independently and significantly associated with specific features of clustering of MetS and prevalence of ischemic cardiovascular diseases. Leukocyte counts, especially neutrophil/lymphocyte ratio, in addition with MetS is associated with the risk of ischemic cardiovascular diseases.
   Conclusion Our results indicate that differential leukocyte counts are associated with MetS and that peripheral leukocytes may play a role in the pathogenesis of macrovascular complications in patients with T2DM. Copyright (c) 2006 John Wiley & Sons, Ltd.
C1 Pingtung Christian Hosp, Dept Clin Res, Pingtung 90000, Taiwan.
   Kaohsiung Med Univ, Grad Inst Med, Kaohsiung 80307, Taiwan.
C3 Kaohsiung Medical University
RP Lee, YJ (corresponding author), Pingtung Christian Hosp, Dept Clin Res, 60 Da Lien Rd, Pingtung 90000, Taiwan.
EM t3275@ms25.hinet.net
RI Shin, Shyi-Jang/A-1523-2010; Sheu, Sheng-Hsiung/C-7445-2009; Chiu,
   Herng-Chia/D-4490-2009
CR Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Albrecht C, 2004, METABOLISM, V53, P17, DOI 10.1016/j.metabol.2003.07.009
   Alexander CM, 2003, DIABETES, V52, P1210, DOI 10.2337/diabetes.52.5.1210
   BJORNSON BH, 1985, J CLIN INVEST, V76, P924, DOI 10.1172/JCI112091
   Caligiuri G, 2005, ARTERIOSCL THROM VAS, V25, P1659, DOI 10.1161/01.ATV.0000172660.24580.b4
   Chen MP, 2005, ARTERIOSCL THROM VAS, V25, P821, DOI 10.1161/01.ATV.0000157784.25920.a7
   Chung FM, 2005, DIABETES CARE, V28, P1710, DOI 10.2337/diacare.28.7.1710
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Coller BS, 2005, ARTERIOSCL THROM VAS, V25, P658, DOI 10.1161/01.ATV.0000156877.94472.a5
   Diamant M, 2002, CIRCULATION, V106, P2442, DOI 10.1161/01.CIR.0000036596.59665.C6
   Elkind MS, 2001, STROKE, V32, P842, DOI 10.1161/01.STR.32.4.842
   ERNST E, 1987, JAMA-J AM MED ASSOC, V257, P2318, DOI 10.1001/jama.257.17.2318
   Fantuzzi G, 2005, J ALLERGY CLIN IMMUN, V115, P911, DOI 10.1016/j.jaci.2005.02.023
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Gainsford T, 1996, P NATL ACAD SCI USA, V93, P14564, DOI 10.1073/pnas.93.25.14564
   GILLUM RF, 1994, J CLIN EPIDEMIOL, V47, P911, DOI 10.1016/0895-4356(94)90195-3
   Gillum RF, 2005, ANN EPIDEMIOL, V15, P266, DOI 10.1016/j.annepidem.2004.08.009
   Hansson GK, 2005, NEW ENGL J MED, V352, P1685, DOI 10.1056/NEJMra043430
   Hoffman M, 2004, ATHEROSCLEROSIS, V172, P1, DOI 10.1016/S0021-9150(03)00164-3
   Hofmann MA, 1998, DIABETES CARE, V21, P1310, DOI 10.2337/diacare.21.8.1310
   Horne BD, 2005, J AM COLL CARDIOL, V45, P1638, DOI 10.1016/j.jacc.2005.02.054
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   KANNEL WB, 1992, JAMA-J AM MED ASSOC, V267, P1253, DOI 10.1001/jama.267.9.1253
   Kielar D, 2001, CLIN CHEM, V47, P2089
   Laharrague P, 2000, INT J OBESITY, V24, P1212, DOI 10.1038/sj.ijo.0801377
   Nagasawa N, 2004, CIRC J, V68, P892, DOI 10.1253/circj.68.892
   Ohshita K, 2004, DIABETES CARE, V27, P491, DOI 10.2337/diacare.27.2.491
   Ommen SR, 1997, AM J CARDIOL, V79, P812, DOI 10.1016/S0002-9149(96)00878-8
   Ommen SR, 1998, CIRCULATION, V97, P19, DOI 10.1161/01.CIR.97.1.19
   Pearson TA, 2003, CIRCULATION, V107, P499, DOI 10.1161/01.CIR.0000052939.59093.45
   Pertynska-Marczewska M, 2004, CYTOKINE, V28, P35, DOI 10.1016/j.cyto.2004.06.006
   Pratley R E, 1995, Obes Res, V3, P563
   Rao AK, 1999, DIABETES, V48, P1156, DOI 10.2337/diabetes.48.5.1156
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Sabatine MS, 2002, J AM COLL CARDIOL, V40, P1761, DOI 10.1016/S0735-1097(02)02484-1
   Scherberich JE, 2003, INT J CLIN PHARM TH, V41, P459
   Shanmugam N, 2003, DIABETES, V52, P1256, DOI 10.2337/diabetes.52.5.1256
   Shurtz-Swirski R, 2001, DIABETES CARE, V24, P104, DOI 10.2337/diacare.24.1.104
   Tan MS, 2003, J CLIN ENDOCR METAB, V88, P1258, DOI 10.1210/jc.2002-021453
   Tanigawa T, 2004, ATHEROSCLEROSIS, V173, P295, DOI 10.1016/j.atherosclerosis.2003.12.019
   Tong PC, 2004, DIABETES CARE, V27, P216, DOI 10.2337/diacare.27.1.216
   Uehara Y, 2002, DIABETES, V51, P2922, DOI 10.2337/diabetes.51.10.2922
   Van Eck M, 2002, P NATL ACAD SCI USA, V99, P6298, DOI 10.1073/pnas.092327399
   van Oostrom AJHHM, 2003, METABOLISM, V52, P199, DOI 10.1053/meta.2003.50037
   Veronelli A, 2004, DIABETES CARE, V27, P2501, DOI 10.2337/diacare.27.10.2501
   Wabitsch M, 1996, DIABETES, V45, P1435, DOI 10.2337/diabetes.45.10.1435
   Walrand S, 2004, J LEUKOCYTE BIOL, V76, P1104, DOI 10.1189/jlb.0104050
   Wheeler JG, 2004, EUR HEART J, V25, P1287, DOI 10.1016/j.ehj.2004.05.002
   WHISNANT JP, 1990, STROKE, V21, P707, DOI 10.1161/01.STR.21.5.707
   Yasunari K, 2002, HYPERTENSION, V39, P777, DOI 10.1161/hy0302.104670
NR 50
TC 84
Z9 94
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD FEB
PY 2007
VL 23
IS 2
BP 111
EP 118
DI 10.1002/dmrr.647
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 141LL
UT WOS:000244579900004
PM 16703635
DA 2025-06-11
ER

PT J
AU Lehto, SM
   Hintikka, J
   Niskanen, L
   Tolmunen, T
   Koivumaa-Honkanen, H
   Honkalampi, K
   Viinamäki, H
AF Lehto, Soili M.
   Hintikka, Jukka
   Niskanen, Leo
   Tolmunen, Tommi
   Koivumaa-Honkanen, Heli
   Honkalampi, Kirsi
   Viinamaki, Heimo
TI Low HDL cholesterol associates with major depression in a sample with a
   7-year history of depressive symptoms
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE atherogenesis; cholesterol; coronary heart disease; high-density
   lipoprotein cholesterol; major depression
ID DENSITY-LIPOPROTEIN CHOLESTEROL; POLYUNSATURATED FATTY-ACIDS;
   SERUM-LIPID CONCENTRATIONS; CHRONIC-FATIGUE-SYNDROME; METABOLIC
   SYNDROME; PLASMA; MEN; SUBTYPES; DISEASE; BINDING
AB Long-term depression may increase the risk for adverse coronary events. Low levels of high-density lipoprotein cholesterol (HDL-C) have in particular been suggested to underlie this connection. A total of 124 participants with a recorded seven-year history of depressive symptoms (depressed, n=63)or euthymic state (controls, n=61) underwent a Structured Clinical Interview for DSM-IV to confirm their psychiatric diagnosis. Total cholesterol (TC), HDL-C and low-density lipoprotein cholesterol (LDL-C) levels, triglycerides, non-HDL-C and atherogenic indices (LDL-C/HDL-C and TC/HDL-C) were assessed. The HDL-C levels were lower and atherogenic indices higher in the depressed group compared with the controls. Furthermore, those with HDL-C level below the gender-adjusted median (< 1.54 mmol/l in women, <1.16 mmol/l in men) were 2.4-fold more likely to be depressed in a model adjusting for age and non-HDL-C (p=0.019). After further adjustment for educational level, marital status, alcohol use. daily smoking and overweight this association remained significant (p=0.049). These findings suggest that compared with the healthy controls, those with long-term depression may have lower HDL-C values and higher atherogenic indices. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Lehto, Soili M.; Hintikka, Jukka; Tolmunen, Tommi; Honkalampi, Kirsi; Viinamaki, Heimo] Kuopio Univ Hosp, Dept Psychiat, SF-70210 Kuopio, Finland.
   [Lehto, Soili M.; Hintikka, Jukka; Niskanen, Leo; Tolmunen, Tommi; Honkalampi, Kirsi; Viinamaki, Heimo] Univ Kuopio, Kuopio 70210, Finland.
   [Niskanen, Leo] Kuopio Univ Hosp, Dept Med, SF-70210 Kuopio, Finland.
   [Koivumaa-Honkanen, Heli] Univ Oulu, Dept Psychiat, Rovaniemi 97140, Finland.
   [Koivumaa-Honkanen, Heli] Lapland Hosp Dist, Rovaniemi 97140, Finland.
C3 University of Eastern Finland; University of Eastern Finland Hospital;
   Kuopio University Hospital; University of Eastern Finland; University of
   Eastern Finland; University of Eastern Finland Hospital; Kuopio
   University Hospital; University of Oulu
RP Lehto, SM (corresponding author), Kuopio Univ Hosp, Dept Psychiat, SF-70210 Kuopio, Finland.
EM Soili.Lehto@kuh.fi
RI Koivumaa-Honkanen, Heli/L-1274-2015
OI Lehto, Soili/0000-0003-4324-6679
FU Kuopio University Hospital EVO; Orion-Farmos Research Foundation,
   AstraZeneca; Foundation for Psychiatric Research
FX SML was supported by Kuopio University Hospital EVO funding, the Finnish
   Graduate School of Psychiatry and grants from the Orion-Farmos Research
   Foundation, AstraZeneca and the Foundation for Psychiatric Research. The
   authors would like to thank Sari Vaisanen, Ph.D., for providing
   technical details on the laboratory methods.
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Anantharamaiah GM, 2007, J LIPID RES, V48, P1915, DOI 10.1194/jlr.R700010-JLR200
   [Anonymous], MODERN NUTR HLTH DIS
   BARRADAS MA, 1992, LANCET, V339, P1168, DOI 10.1016/0140-6736(92)90768-X
   Barter P, 2007, NEW ENGL J MED, V357, P1301, DOI 10.1056/NEJMoa064278
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   Broadley AJM, 2002, HEART, V88, P521, DOI 10.1136/heart.88.5.521
   Broadley AJM, 2006, J AM COLL CARDIOL, V48, P170, DOI 10.1016/j.jacc.2005.12.078
   Chen CC, 2001, PSYCHIAT RES, V102, P153, DOI 10.1016/S0165-1781(01)00231-1
   De Lorenzo F, 1998, QJM-INT J MED, V91, P475, DOI 10.1093/qjmed/91.7.475
   Deisenhammer EA, 2004, PSYCHIAT RES, V121, P253, DOI 10.1016/j.psychres.2003.09.007
   ENGELBERG H, 1992, LANCET, V339, P727, DOI 10.1016/0140-6736(92)90609-7
   Fountoulakis KN, 2004, PROG NEURO-PSYCHOPH, V28, P537, DOI 10.1016/j.pnpbp.2004.01.006
   Frasure-Smith N, 2008, ARCH GEN PSYCHIAT, V65, P62, DOI 10.1001/archgenpsychiatry.2007.4
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Grippo AJ, 2002, NEUROSCI BIOBEHAV R, V26, P941, DOI 10.1016/S0149-7634(03)00003-4
   Gurer G, 2006, CLIN RHEUMATOL, V25, P300, DOI 10.1007/s10067-005-0004-5
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Huang TL, 2005, J AFFECT DISORDERS, V86, P75, DOI 10.1016/j.jad.2004.11.005
   Huang TL, 2004, PSYCHIAT CLIN NEUROS, V58, P295, DOI 10.1111/j.1440-1819.2004.01235.x
   Huang TL, 2003, PSYCHIAT RES, V118, P147, DOI 10.1016/S0165-1781(03)00071-4
   Iso H, 2006, CIRCULATION, V113, P195, DOI 10.1161/CIRCULATIONAHA.105.581355
   KAPLAN JR, 1994, PSYCHOSOM MED, V56, P479, DOI 10.1097/00006842-199411000-00001
   Kennedy G, 2005, FREE RADICAL BIO MED, V39, P584, DOI 10.1016/j.freeradbiomed.2005.04.020
   Lehto S, 2006, PROG NEURO-PSYCHOPH, V30, P1251, DOI 10.1016/j.pnpbp.2006.03.019
   Lehto SM, 2008, PROG NEURO-PSYCHOPH, V32, P229, DOI 10.1016/j.pnpbp.2007.08.013
   Leon AS, 2001, MED SCI SPORT EXER, V33, pS502, DOI 10.1097/00005768-200106001-00021
   LINDBERG G, 1994, J EPIDEMIOL COMMUN H, V48, P360, DOI 10.1136/jech.48.4.360
   Maes M, 1999, PSYCHIAT RES, V85, P275, DOI 10.1016/S0165-1781(99)00014-1
   MAES M, 1995, J AFFECT DISORDERS, V34, P301, DOI 10.1016/0165-0327(95)00028-L
   MAES M, 1994, ACTA PSYCHIAT SCAND, V90, P252, DOI 10.1111/j.1600-0447.1994.tb01589.x
   Maes M, 1996, J AFFECT DISORDERS, V38, P35, DOI 10.1016/0165-0327(95)00092-5
   Maes M, 1997, ACTA PSYCHIAT SCAND, V95, P212, DOI 10.1111/j.1600-0447.1997.tb09622.x
   McGinn LK, 1996, PSYCHIAT RES, V60, P191, DOI 10.1016/0165-1781(96)02781-3
   Merikangas KR, 2003, ARCH GEN PSYCHIAT, V60, P993, DOI 10.1001/archpsyc.60.9.993
   Mittal VA, 2011, PSYCHIAT RES, V189, P158, DOI 10.1016/j.psychres.2011.06.006
   Olusi SO, 1996, BIOL PSYCHIAT, V40, P1128, DOI 10.1016/S0006-3223(95)00599-4
   POLLOCK BG, 1994, PSYCHOPHARMACOL BULL, V30, P145
   Rajagopalan S, 2001, AM J CARDIOL, V88, P196, DOI 10.1016/S0002-9149(01)01623-X
   Sabine JR., 1977, Cholesterol
   SALTER M, 1992, LANCET, V339, P1169
   Sarandol A, 2006, PROG NEURO-PSYCHOPH, V30, P1103, DOI 10.1016/j.pnpbp.2006.04.012
   SHIH JC, 1983, NEUROCHEM RES, V8, P701, DOI 10.1007/BF00964727
   Sobczak S, 2004, PSYCHOL MED, V34, P103, DOI 10.1017/S0033291703001090
   Sonnenberg LM, 1996, J CLIN EPIDEMIOL, V49, P665, DOI 10.1016/0895-4356(96)00031-5
   Sullivan DH, 1999, JAMA-J AM MED ASSOC, V281, P2013, DOI 10.1001/jama.281.21.2013
   Terao T, 2000, PSYCHIAT RES, V96, P167, DOI 10.1016/S0165-1781(00)00197-9
   Twisk JWR, 2000, MED SCI SPORT EXER, V32, P1455, DOI 10.1097/00005768-200008000-00014
   Vogelzangs N, 2007, PSYCHONEUROENDOCRINO, V32, P151, DOI 10.1016/j.psyneuen.2006.11.009
   Williams JBW, 2003, Structured Interview Guide For the Hamilton Depression Rating Scale with Atypical Depression Supplement
NR 50
TC 70
Z9 77
U1 0
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD AUG 1
PY 2008
VL 32
IS 6
BP 1557
EP 1561
DI 10.1016/j.pnpbp.2008.05.021
PG 5
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 342YJ
UT WOS:000258819200030
PM 18583011
DA 2025-06-11
ER

PT J
AU Parklak, W
   Chuljerm, H
   Kawichai, S
   Fakfum, P
   Jiraya, P
   Kijkuokool, P
   Khiaolaongam, W
   Ngamsang, P
   Ounjaijean, S
   Rerkasem, K
   Kulprachakarn, K
AF Parklak, Wason
   Chuljerm, Hataichanok
   Kawichai, Sawaeng
   Fakfum, Puriwat
   Jiraya, Putita
   Kijkuokool, Praporn
   Khiaolaongam, Wiritphon
   Ngamsang, Pakaphorn
   Ounjaijean, Sakaewan
   Rerkasem, Kittipan
   Kulprachakarn, Kanokwan
TI The Impact of Nutrition and Fine Particulate Matter (PM2.5) on
   Inflammatory Responses in Individuals with Metabolic Syndrome: A Paired
   Case Study from Chiang Mai, Thailand
SO TOXICS
LA English
DT Article
DE PM2.5; nutrition; inflammation; dietary fiber; antioxidant vitamins;
   metabolic syndrome
ID OXIDATIVE STRESS; BLOOD-PRESSURE; AIR-POLLUTION; ANTIOXIDANT; HEALTHY;
   EXPOSURE; PHYTOCHEMICALS; DISEASE; MARKERS; SODIUM
AB Exposure to fine particulate matter (PM2.5) is linked to increased systemic inflammation, particularly in individuals with metabolic syndrome (MS). This study assessed the impact of nutrition and PM2.5 exposure on inflammatory markers in individuals with MS. A total of 50 participants (25 with MS, 25 healthy controls) were monitored during a high-PM2.5 exposure period (HEP) and a low-PM2.5 exposure period (LEP). Dietary intake, health assessments, and inflammatory markers-TNF-alpha, IL-6, and CRP-were evaluated. The MS group had significantly higher BMI, fasting blood glucose, and triglyceride levels and lower HDL-C than the healthy group (p < 0.01), but these parameters did not change significantly between the HEP and LEP. Notably, dietary fiber intake increased in the MS group during the LEP (p < 0.05). CRP levels were higher in the MS group and significantly decreased in both groups during the LEP (p < 0.05). IL-6 was higher in the MS group during the HEP but did not significantly change across periods. TNF-alpha showed no differences. Dietary fiber intake was inversely correlated with IL-6 and CRP in the healthy group and strongly correlated with CRP in the MS group (r = -0.403, p < 0.01). Antioxidant vitamins were inversely correlated with inflammation only in healthy participants. These findings suggest that an increased dietary fiber intake may help reduce PM2.5-induced inflammation, particularly in individuals with MS.
C1 [Parklak, Wason; Chuljerm, Hataichanok; Kawichai, Sawaeng; Fakfum, Puriwat; Jiraya, Putita; Ounjaijean, Sakaewan; Rerkasem, Kittipan; Kulprachakarn, Kanokwan] Chiang Mai Univ, Res Inst Hlth Sci, Res Ctr Noninfect Dis & Environm Hlth, Chiang Mai 50200, Thailand.
   [Chuljerm, Hataichanok; Kijkuokool, Praporn; Khiaolaongam, Wiritphon; Ngamsang, Pakaphorn; Ounjaijean, Sakaewan; Kulprachakarn, Kanokwan] Chiang Mai Univ, Res Inst Hlth Sci, Sch Hlth Sci Res, Chiang Mai 50200, Thailand.
   [Rerkasem, Kittipan] Chiang Mai Univ, Fac Med, Clin Surg Res Ctr, Dept Surg, Chiang Mai 50200, Thailand.
C3 Chiang Mai University; Chiang Mai University; Chiang Mai University
RP Kulprachakarn, K (corresponding author), Chiang Mai Univ, Res Inst Hlth Sci, Res Ctr Noninfect Dis & Environm Hlth, Chiang Mai 50200, Thailand.; Kulprachakarn, K (corresponding author), Chiang Mai Univ, Res Inst Hlth Sci, Sch Hlth Sci Res, Chiang Mai 50200, Thailand.
EM wason.p@cmu.ac.th; hataichanok.ch@cmu.ac.th; sawaeng.kaw@cmu.ac.th;
   nuengpuriwat@gmail.com; putita_jiraya@cmu.ac.th; praporn_k@cmu.ac.th;
   wiritphon_k@cmu.ac.th; pakaporn_ng@cmu.ac.th; sakaewan.o@cmu.ac.th;
   rerkase@gmail.com; kanokwan.kul@cmu.ac.th
RI Ounjaijean, Sakaewan/GQB-2632-2022; Chuljerm, Hataichanok/HZM-0882-2023;
   Kulprachakarn, Kanokwan/P-6170-2019; Kawichai, Sawaeng/AHI-1315-2022
FU Chiang Mai University;  [PM 11/2566]
FX This research was partially supported by Chiang Mai University (grant
   number: PM 11/2566).
CR Agay D, 2005, BURNS, V31, P366, DOI 10.1016/j.burns.2004.11.010
   Ashor AW, 2014, ATHEROSCLEROSIS, V235, P9, DOI 10.1016/j.atherosclerosis.2014.04.004
   Basdeki ED, 2021, NUTRIENTS, V13, DOI 10.3390/nu13082632
   Bowe B, 2019, JAMA NETW OPEN, V2, DOI 10.1001/jamanetworkopen.2019.15834
   Campolim CM, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-67040-3
   Chanda F, 2024, SCI TOTAL ENVIRON, V954, DOI 10.1016/j.scitotenv.2024.176255
   Chen CH, 2007, J GASTROEN HEPATOL, V22, P1482, DOI 10.1111/j.1440-1746.2006.04615.x
   Choi JeongHwa Choi JeongHwa, 2017, Journal of Nutrition and Health, V50, P578, DOI 10.4163/jnh.2017.50.6.578
   Costa APR, 2012, ATHEROSCLEROSIS, V222, P284, DOI 10.1016/j.atherosclerosis.2012.02.037
   Dabass A, 2018, ENVIRON RES, V161, P485, DOI 10.1016/j.envres.2017.11.042
   Delanaye P, 2017, NEPHRON, V136, P302, DOI 10.1159/000469669
   Elbarbary M, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18063258
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Fu HY, 2020, INFLAMMATION, V43, P1948, DOI 10.1007/s10753-020-01269-y
   Guo YL, 2024, NUTR REV, V82, P654, DOI 10.1093/nutrit/nuad077
   Han SC, 2022, ENVIRON RES, V215, DOI 10.1016/j.envres.2022.114340
   Horváth M, 2018, ACTA AGR SCAND A-AN, V68, P152, DOI 10.1080/09064702.2019.1611913
   Hosten AO., 1990, Clinical Methods: The History, Physical, and Laboratory Examinations, V3rd
   Hu HJ, 2016, TOXICOL RES-UK, V5, P946, DOI 10.1039/c5tx00351b
   Huang K, 2023, ENVIRON HEALTH-GLOB, V22, DOI 10.1186/s12940-023-01000-y
   Iyer HS, 2022, ENVIRON RES, V214, DOI 10.1016/j.envres.2022.113810
   Jarernwong K, 2023, ATMOSPHERE-BASEL, V14, DOI 10.3390/atmos14020261
   Ju K, 2023, J CLEAN PROD, V433, DOI 10.1016/j.jclepro.2023.139609
   Kakkar Sahil, 2014, ISRN Pharmacol, V2014, P952943, DOI 10.1155/2014/952943
   Kang HS, 2011, J GASTROEN HEPATOL, V26, P292, DOI 10.1111/j.1440-1746.2010.06481.x
   Karim N, 2024, BMJ OPEN, V14, DOI 10.1136/bmjopen-2023-079826
   Kim Kyoungwoo, 2009, Environmental Health and Preventive Medicine, V14, P60, DOI 10.1007/s12199-008-0060-y
   Klöslová Z, 2016, CENT EUR J PUBL HEAL, V24, P302, DOI 10.21101/cejph.a4179
   Krittanawong C, 2023, CURR PROB CARDIOLOGY, V48, DOI 10.1016/j.cpcardiol.2023.101670
   Li J, 2023, ENVIRON RES, V220, DOI 10.1016/j.envres.2023.115238
   Li RY, 2018, ONCOL LETT, V15, P7506, DOI 10.3892/ol.2018.8355
   Li WL, 2023, ECOTOX ENVIRON SAFE, V262, DOI 10.1016/j.ecoenv.2023.115156
   Liang RJ, 2014, J HYPERTENS, V32, P2130, DOI 10.1097/HJH.0000000000000342
   Lin HL, 2017, HYPERTENSION, V69, P806, DOI [10.1161/HYPERTENSIONAHA.116.08839, 10.1161/hypertensionaha.116.08839]
   Liu CW, 2018, PART FIBRE TOXICOL, V15, DOI 10.1186/s12989-018-0240-x
   Long MH, 2020, ENVIRON POLLUT, V256, DOI 10.1016/j.envpol.2019.113342
   Lu CY, 2007, ENVIRON RES, V103, P331, DOI 10.1016/j.envres.2006.08.009
   Luu HN, 2015, ANTIOXID REDOX SIGN, V22, P951, DOI 10.1089/ars.2014.6212
   Ma YS, 2008, NUTRITION, V24, P941, DOI 10.1016/j.nut.2008.04.005
   Mendes FD, 2020, PEDIAT ALLERG IMM-UK, V31, P290, DOI 10.1111/pai.13185
   Mostafanezhad M, 2025, SINGAPORE J TROP GEO, V46, P186, DOI 10.1111/sjtg.12578
   Nguyen TTU, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222111923
   Niero M, 2023, NUTRIENTS, V15, DOI 10.3390/nu15102365
   O'Donnell M, 2014, CURR CARDIOL REP, V16, DOI 10.1007/s11886-014-0529-9
   Pan K, 2019, ECOTOX ENVIRON SAFE, V179, P290, DOI 10.1016/j.ecoenv.2019.04.038
   Parasin N, 2024, PEERJ, V12, DOI 10.7717/peerj.18055
   Pirard C., 2023, arXiv, DOI [10.31223/X5509C, DOI 10.31223/X5509C]
   Purkins L, 2004, BRIT J CLIN PHARMACO, V57, P199, DOI 10.1046/j.1365-2125.2003.01969.x
   Reifen R, 2002, P NUTR SOC, V61, P397, DOI 10.1079/PNS2002172
   Rodriguez-Casado A, 2016, CRIT REV FOOD SCI, V56, P1097, DOI 10.1080/10408398.2012.755149
   Sabir S, 2025, PEERJ, V13, DOI 10.7717/peerj.19047
   Satheannoppakao Warapone, 2013, Journal of the Medical Association of Thailand, V96, pS161
   Su MZ, 2024, NUTRIENTS, V16, DOI 10.3390/nu16060888
   Sun BY, 2020, J HAZARD MATER, V385, DOI 10.1016/j.jhazmat.2019.121566
   Thangavel P, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19127511
   Tian C, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/7398453
   Ungurianu A, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10050634
   Vega MW, 2020, PEDIATRICS, V146, DOI 10.1542/peds.2019-2828
   WHO, 2021, WHO GLOBAL AIR QUALI
   Yang S, 2021, INT J MOL MED, V47, DOI 10.3892/ijmm.2021.4878
   Yang YS, 2024, BMC PUBLIC HEALTH, V24, DOI 10.1186/s12889-024-19116-2
   Zhang CX, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1212291
   Zhang H, 2016, CURR OPIN FOOD SCI, V8, P33, DOI 10.1016/j.cofs.2016.02.002
   Zhang JJ, 2024, FRONT PUBLIC HEALTH, V12, DOI 10.3389/fpubh.2024.1462548
   Zhang L, 2024, ECOTOX ENVIRON SAFE, V277, DOI 10.1016/j.ecoenv.2024.116386
   Zhang YJ, 2015, MOLECULES, V20, P21138, DOI 10.3390/molecules201219753
   Zhao MQ, 2022, ENVIRON RES, V204, DOI 10.1016/j.envres.2021.112352
   Zhu HD, 2014, PEDIATRICS, V133, pE635, DOI 10.1542/peds.2013-1794
NR 68
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2305-6304
J9 TOXICS
JI Toxics
PD APR 22
PY 2025
VL 13
IS 5
AR 325
DI 10.3390/toxics13050325
PG 23
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA 3BE6L
UT WOS:001496170700001
PM 40423404
OA gold
DA 2025-06-11
ER

PT J
AU Zhong, Y
   Wang, TH
   Huang, LJ
   Hua, YS
AF Zhong, Yuan
   Wang, Tian-Hong
   Huang, Li-Jiang
   Hua, Yu-Si
TI Association between metabolic syndrome and the risk of Parkinson's
   disease: a meta-analysis
SO BMC NEUROLOGY
LA English
DT Review
DE Metabolic syndrome; Parkinson's disease; Risk factors; Meta-analysis
ID C-REACTIVE PROTEIN; OXIDATIVE STRESS; MARKERS; LINK
AB BackgroundThere is still a lack of knowledge about the relationship between metabolic syndrome (MetS) and Parkinson's disease (PD). This study aimed to determine whether MetS increases PD risk.MethodsTo identify relevant clinical studies, databases such as PubMed, Embase, and the Cochrane Library were searched in depth from the inception of databases until March 31, 2024. The study evaluated the correlation between MetS and the likelihood of developing PD through the computation of aggregated relative risks (RR) and their respective 95% confidence intervals (CIs) utilizing selnRR and lnRR.ResultsSeven studies were included in our systematic review. The meta-analysis revealed that patients with MetS have a 0.3-fold increased risk of developing PD (p = 0.001). Furthermore, the analysis revealed a positive correlation between central obesity and the incidence of PD, with an RR of 1.19 (95% CI, 1.16-1.22; p = 0.001), as well as a greater risk of PD in patients with elevated blood pressure, with an RR of 1.13 (95% CI, 1.07-1.19; p = 0.001); elevated serum triglyceride levels, with an RR of 1.09 (95% CI, 1.02-1.15; p = 0.001); lower serum HDL cholesterol levels, with an RR of 1.21 (95% CI, 1.15-1.28; p = 0.001); and elevated plasma fasting glucose levels, with an RR of 1.18 (95% CI, 1.11-1.26; p = 0.001).ConclusionMetS can contribute to the incidence of Parkinson's disease, with individual components of MetS demonstrating comparable effects.
C1 [Zhong, Yuan] Sichuan Univ, West China Hosp, West China Sch Nursing, Dept Anesthesiolo, Chengdu, Sichuan, Peoples R China.
   [Wang, Tian-Hong; Hua, Yu-Si] Sichuan Univ, West China Hosp, Dept Anesthesiol, Chengdu 610041, Peoples R China.
   [Huang, Li-Jiang] Chongqing Med Univ, Peoples Hosp Xiushan Cty, Dept Neurol, Chongqing, Peoples R China.
C3 Sichuan University; Sichuan University; Chongqing Medical University
RP Hua, YS (corresponding author), Sichuan Univ, West China Hosp, Dept Anesthesiol, Chengdu 610041, Peoples R China.
EM yusihua@wchscu.cn
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Armutcu F, 2008, CLIN CHEM LAB MED, V46, P785, DOI 10.1515/CCLM.2008.166
   Blesa J, 2015, FRONT NEUROANAT, V9, DOI 10.3389/fnana.2015.00091
   Jeong E, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-96147-4
   Li LY, 2023, REV NEUROSCIENCE, V34, P719, DOI 10.1515/revneuro-2022-0093
   Mei M, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1243132
   Moreira PI, 2007, J NEUROL SCI, V257, P206, DOI 10.1016/j.jns.2007.01.017
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Naderali EK, 2009, AM J ALZHEIMERS DIS, V24, P445, DOI 10.1177/1533317509348208
   Nam GE, 2018, PLOS MED, V15, DOI 10.1371/journal.pmed.1002640
   Noyce AJ, 2012, ANN NEUROL, V72, P893, DOI 10.1002/ana.23687
   Park SH, 2021, J PARKINSON DIS, V11, P1751, DOI 10.3233/JPD-212589
   Peng ZY, 2018, PARKINSONISM RELAT D, V55, P68, DOI 10.1016/j.parkreldis.2018.05.013
   Ridker PM, 2000, NEW ENGL J MED, V342, P836, DOI 10.1056/NEJM200003233421202
   Roh JH, 2021, METAB SYNDR RELAT D, V19, P1, DOI 10.1089/met.2020.0060
   Sääksjärvi K, 2015, PARKINSONISM RELAT D, V21, P1148, DOI 10.1016/j.parkreldis.2015.07.017
   Stang A, 2010, EUR J EPIDEMIOL, V25, P603, DOI 10.1007/s10654-010-9491-z
   Stroup DF, 2000, JAMA-J AM MED ASSOC, V283, P2008, DOI 10.1001/jama.283.15.2008
   Twelves D, 2003, MOVEMENT DISORD, V18, P19, DOI 10.1002/mds.10305
   Yoo D, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-58306-x
   Zhang P, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/729194
   Zhou C, 2008, ANN NY ACAD SCI, V1147, P93, DOI 10.1196/annals.1427.023
NR 22
TC 2
Z9 2
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2377
J9 BMC NEUROL
JI BMC Neurol.
PD SEP 4
PY 2024
VL 24
IS 1
AR 313
DI 10.1186/s12883-024-03820-y
PG 8
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA E9Y1B
UT WOS:001306473700007
PM 39232681
OA gold
DA 2025-06-11
ER

PT J
AU Xu, HY
   Xu, JY
   Liu, XY
   Song, W
   Lyu, X
   Guo, XA
   Hu, WJ
   Yang, HB
   Wang, LJ
   Pan, H
   Chen, JC
   Xing, XP
   Zhu, HJ
   Sun, W
   Gong, FY
AF Xu, Hanyuan
   Xu, Jiyu
   Liu, Xiaoyan
   Song, Wei
   Lyu, Xiaorui
   Guo, Xiaonan
   Hu, Wenjing
   Yang, Hongbo
   Wang, Linjie
   Pan, Hui
   Chen, Jichun
   Xing, Xiaoping
   Zhu, Huijuan
   Sun, Wei
   Gong, Fengying
TI Serum metabolomics profiling of improved metabolic syndrome is
   characterized by decreased pro-inflammatory biomarkers: A longitudinal
   study in Chinese male adults
SO NUTRITION RESEARCH
LA English
DT Article
DE Metabolic syndrome (MetS); Metabolomics; Prostaglandin E2;
   Neuroprotectin D1; Taxiphyllin; Longitudinal study
ID CYTOKINE PRODUCTION; OBESITY; EXERCISE; DISEASE; DIET; FAT;
   CYCLOOXYGENASE-2; SUPPLEMENTATION; PGE(2); BRAIN
AB Metabolic syndrome (MetS) is a serious global health concern. The objective of this study is to dynamically investigate the changes of metabolic profiles and metabolites in Chinese male MetS subjects after an 18 months diet and exercise intervention. Fifty male MetS patients defined according to International Diabetes Federation 2005 guidelines were sub-jected to diet and exercise counseling for 18 months. Serum samples were taken at baseline, 12 months, and 18 months, respectively, for clinical evaluation and metabolomics analy- ses. Diet and exercise intervention for 18 months achieved significant improvements in the metabolic profiles of all participants. Nineteen subjects (38.0%) exhibited MetS remission at the end of the study. A total of 812 relative features were characterized and 61 were success-fully identified. Furthermore, 17 differential metabolites were of significance at both time points (baseline-12 months, baseline-18 months) and presented nonlinear trends through time. Eight metabolites (47.1%) were predominantly converged to inflammation and oxida-tive stress. Pro-inflammatory biomarkers were remarkably decreased after 18 months of in-tervention, and prostaglandin E2, neuroprotectin D1, and taxiphyllin in combination were firstly found to demonstrate a fair discriminative power (area under curve = 0.911) to predict the improvement of MetS undergone diet and exercise intervention. The significant shift of metabolomic profiling after 18 months of lifestyle counseling provide a novel insight and reveal that earlier inflammation control may be of potential benefit in MetS management.(c) 2023 Published by Elsevier Inc.
C1 [Xu, Hanyuan; Lyu, Xiaorui; Guo, Xiaonan; Hu, Wenjing; Yang, Hongbo; Wang, Linjie; Pan, Hui; Xing, Xiaoping; Zhu, Huijuan; Gong, Fengying] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Key Lab Endocrinol, Natl Hlth Commiss,Dept Endocrinol, Beijing 100730, Peoples R China.
   [Xu, Hanyuan] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Clin Nutr, Beijing 100730, Peoples R China.
   [Xu, Jiyu; Liu, Xiaoyan; Sun, Wei] Chinese Acad Med Sci, Peking Union Med Coll, Sch Basic Med, Inst Basic Med Sci, Beijing, Peoples R China.
   [Song, Wei] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, State Key Lab Complex Severe & Rare Dis, Med Sci Res Ctr, Beijing 100730, Peoples R China.
   [Chen, Jichun] Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Nutr Dept, 167 Beilishi Rd, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Institute of Basic Medical Sciences -
   CAMS; Chinese Academy of Medical Sciences - Peking Union Medical
   College; Peking Union Medical College Hospital; Peking Union Medical
   College; Chinese Academy of Medical Sciences - Peking Union Medical
   College; Fu Wai Hospital - CAMS; Peking Union Medical College
RP Zhu, HJ; Gong, FY (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Key Lab Endocrinol, Natl Hlth Commiss,Dept Endocrinol, Beijing 100730, Peoples R China.; Sun, W (corresponding author), Chinese Acad Med Sci, Peking Union Med Coll, Sch Basic Med, Inst Basic Med Sci, Beijing, Peoples R China.
EM shengxin2004@163.com; sunwei1018@sina.com; fygong@sina.com
RI Liu, XiaoYan/GQA-7216-2022; Song, Wei/GQH-3892-2022
FU CAMS Innovation Fund for Medical Sciences (CIFMS) [2022-I2M-2-002];
   National Natural Science Foundation of China [82270913]; Beijing Natural
   Science Foundation [7222137]; National Key Technology Research and
   Development Program of China during the "11th Five-Year Plan" from the
   Ministry of Science and Technology [2006BAI01A01]; National Key Clinical
   Specialty Capacity Improvement Project; Innovation fund for postgraduate
   students of Peking Union Medical College [2019-1002-26]
FX This work was supported by the CAMS Innovation Fund for Medical Sciences
   (CIFMS) (No. 2022-I2M-2-002), the National Natural Science Foundation of
   China (No.82270913), Beijing Natural Science Foundation (No. 7222137),
   National Key Technology Research and Development Program of China during
   the "11th Five-Year Plan" from the Ministry of Science and Technology
   (2006BAI01A01), National Key Clinical Specialty Capacity Improvement
   Project, and the Innovation fund for postgraduate students of Peking
   Union Medical College (2019-1002-26).
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Allen F, 2014, NUCLEIC ACIDS RES, V42, pW94, DOI 10.1093/nar/gku436
   Anderssen SA, 2007, SCAND J MED SCI SPOR, V17, P687, DOI 10.1111/j.1600-0838.2006.00631.x
   Andou A, 2009, GASTROENTEROLOGY, V136, P564, DOI 10.1053/j.gastro.2008.09.062
   [Anonymous], 2016, CHINESE DIETARY GUID, P57
   Antonini R, 2020, METAB BRAIN DIS, V35, P295, DOI 10.1007/s11011-019-00525-x
   Babizhayev MA, 2009, J DRUG TARGET, V17, P36, DOI 10.1080/10611860802438736 
   Bazan NG, 2005, BRAIN PATHOL, V15, P159
   Brand JS, 2013, DIABETES CARE, V36, P1012, DOI 10.2337/dc12-1020
   Bruzzone C, 2021, CARDIOVASC DIABETOL, V20, DOI 10.1186/s12933-021-01349-9
   Camhi SM, 2010, OBESITY, V18, P548, DOI 10.1038/oby.2009.304
   Chan PC, 2016, FASEB J, V30, P2282, DOI 10.1096/fj.201500127
   Comte B, 2021, EBIOMEDICINE, V69, DOI 10.1016/j.ebiom.2021.103440
   Cornier MA, 2008, ENDOCR REV, V29, P777, DOI 10.1210/er.2008-0024
   DiNicolantonio JJ, 2018, OPEN HEART, V5, DOI 10.1136/openhrt-2017-000676
   Dong LM, 2009, CANCER EPIDEM BIOMAR, V18, P3075, DOI 10.1158/1055-9965.EPI-09-0680
   Fiume MM, 2019, INT J TOXICOL, V38, pS5, DOI 10.1177/1091581819856568
   García-Alonso V, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0153751
   Goldfine AB, 2017, J CLIN INVEST, V127, P83, DOI 10.1172/JCI88884
   Guo Q, 2017, CHIN J NAT MEDICINES, V15, P525, DOI 10.1016/S1875-5364(17)30078-X
   Haley AP, 2012, METAB BRAIN DIS, V27, P513, DOI 10.1007/s11011-012-9306-x
   Higaki T, 2012, CLIN EXP ALLERGY, V42, P1217, DOI 10.1111/j.1365-2222.2012.04015.x
   Horai H, 2008, INT CONF BIOMED, P853, DOI 10.1109/BMEI.2008.339
   Huang CF, 2013, DIABETES CARE, V36, P1729, DOI 10.2337/dc12-1067
   Jiang MX, 2014, J BIOL CHEM, V289, P8086, DOI 10.1074/jbc.M113.535914
   Jing ZW, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.692893
   Katakura M, 2014, MOLECULES, V19, P3247, DOI 10.3390/molecules19033247
   Klevorn CM, 2019, J FOOD SCI, V84, P397, DOI 10.1111/1750-3841.14450
   Klimis H, 2021, AM HEART J, V242, P33, DOI 10.1016/j.ahj.2021.08.009
   Li YR, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0199293
   Lin Z, 2014, ANAL CHIM ACTA, V827, P22, DOI [10.1016/j.aca.2014.04.008, 10.1016/j.aca.2014.04.039]
   Liu X, 2020, FRONT ONCOL, V10, DOI 10.3389/fonc.2020.00717
   Lumeng CN, 2011, J CLIN INVEST, V121, P2111, DOI 10.1172/JCI57132
   Maltais-Payette I, 2019, NUTR METAB CARDIOVAS, V29, P1353, DOI 10.1016/j.numecd.2019.08.015
   Marcheselli VL, 2003, J BIOL CHEM, V278, P43807, DOI 10.1074/jbc.M305841200
   Naska Androniki, 2017, F1000Res, V6, P926, DOI 10.12688/f1000research.10703.1
   Nasrallah R, 2016, J AM SOC NEPHROL, V27, P666, DOI 10.1681/ASN.2015050528
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Oldroyd JC, 2006, DIABETES RES CLIN PR, V72, P117, DOI 10.1016/j.diabres.2005.09.018
   Villumsen SO, 2022, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.742736
   Ormstad H, 2013, J MOL NEUROSCI, V51, P893, DOI 10.1007/s12031-013-0097-2
   Othman A, 2012, DIABETOLOGIA, V55, P421, DOI 10.1007/s00125-011-2384-1
   Palmer MK, 2019, OBESITY, V27, P309, DOI 10.1002/oby.22370
   Pawelzik SC, 2019, PROSTAG OTH LIPID M, V145, DOI 10.1016/j.prostaglandins.2019.106361
   Ramkissoon A, 2013, MOLECULAR BASIS OF OXIDATIVE STRESS: CHEMISTRY, MECHANISMS, AND DISEASE PATHOGENESIS, P234
   Rocha-Rodrigues S, 2017, INT J BIOCHEM CELL B, V87, P114, DOI 10.1016/j.biocel.2017.04.008
   Rudy CC, 2015, AGING DIS, V6, P131, DOI 10.14336/AD.2014.0423
   Schoenberger SD, 2012, INVEST OPHTH VIS SCI, V53, P5906, DOI 10.1167/iovs.12-10410
   Selevsek N, 2011, PROTEOMICS, V11, P1135, DOI 10.1002/pmic.201000599
   Takahashi TA, 2015, MED CLIN N AM, V99, P521, DOI 10.1016/j.mcna.2015.01.006
   Tan SP, 2017, CLIN COSMET INV DERM, V10, P403, DOI 10.2147/CCID.S146760
   van Rees BP, 2002, J PATHOL, V196, P171, DOI 10.1002/path.1033
   Wang J, 2014, NEUROPHARMACOLOGY, V79, P249, DOI 10.1016/j.neuropharm.2013.11.022
   Woods Nancy Fugate, 2005, Am J Med, V118 Suppl 12B, P14
   Xu HY, 2022, DIABETOL METAB SYNDR, V14, DOI 10.1186/s13098-022-00793-1
   Xu YF, 2021, CELL MOL NEUROBIOL, V41, P1483, DOI 10.1007/s10571-020-00911-5
   Yao CC, 2019, BRIT J PHARMACOL, V176, P337, DOI 10.1111/bph.14530
   Yi WJ, 2019, BIOMED PHARMACOTHER, V116, DOI 10.1016/j.biopha.2019.108980
   Yokota T, 2002, J CLIN INVEST, V109, P1303, DOI 10.1172/JCI200214506
   Zeng L, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222212598
   Zhao GH, 2018, INT J BIOL MACROMOL, V108, P550, DOI 10.1016/j.ijbiomac.2017.12.057
NR 61
TC 1
Z9 1
U1 1
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
EI 1879-0739
J9 NUTR RES
JI Nutr. Res.
PD JUL
PY 2023
VL 115
BP 13
EP 25
DI 10.1016/j.nutres.2023.04.006
EA MAY 2023
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA J4JE1
UT WOS:001009284000001
PM 37216838
DA 2025-06-11
ER

PT J
AU Conde-Pipó, J
   Bouzas, C
   Mariscal-Arcas, M
   Tur, JA
AF Conde-Pipo, Javier
   Bouzas, Cristina
   Mariscal-Arcas, Miguel
   Tur, Josep A.
TI Association between Functional Fitness and Health-Related Quality of
   Life in the Balearic Islands' Old Adults with Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; physical activity; fitness; quality of life; older
   adults
ID PHYSICAL-ACTIVITY; MEDITERRANEAN POPULATION; EXERCISE; ADHERENCE;
   QUESTIONNAIRES; DETERMINANTS; PREVALENCE; PROGRAMS; VALIDITY; STRESS
AB Research assessing the relationship between functional fitness (FF) and health-related quality of life (HRQoL) is still scarce. The objective of this research is to assess the association between FF and HRQoL in older adults with metabolic syndrome (MetS) from Balearic Islands (Spain). The design is a cross-sectional, descriptive, and comparative study involving 209 participants (42.2% women). The sociodemographic data and medical history of the participants were collected. Physical activity was evaluated using the Spanish version of the Rapid Assessment of Physical Activity Questionnaire. Anthropometrics and blood pressure were measured. Glucose, total cholesterol, high-density lipoprotein cholesterol, and triglyceride plasma levels were measured. A battery of functional fitness tests was applied. HRQoL was measured with the Spanish version of the SF-36 questionnaire. Adherence to the Mediterranean dietary pattern was assessed. In older subjects with MetS, a higher FF score and, within it, endurance, lower body strength, one-leg balance, and agility are positively associated with lower physical function (p < 0.001; d = 0.56), better general health (p = 0.019; d = 0.35), and better summary physical component of HRQoL (p < 0.001; d = 0.57). The FF score and HRQoL physical component are both positively associated with high levels of physical activity (ORadj = 10.3, IC 4.19-28.2, p < 0.001; ORadj = 3.25, IC 1.44-7.72, p < 0.005). Older adults with MetS should consider practicing physical activity above the general recommendations to improve their functional fitness and health status and quality of life.
C1 [Conde-Pipo, Javier] Univ Granada, Fac Educ Sci, Dept Didact Mus Plast & Corporal, Granada 18071, Spain.
   [Bouzas, Cristina; Tur, Josep A.] Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.
   [Bouzas, Cristina; Tur, Josep A.] Hlth Inst Balearic Isl IDISBA, Palma De Mallorca 07120, Spain.
   [Bouzas, Cristina; Tur, Josep A.] Inst Salud Carlos III ISCIII, CIBEROBN Physiopathol Obes & Nutr CB12 03 30038, Madrid 28029, Spain.
   [Mariscal-Arcas, Miguel] Univ Granada, Sch Pharm, Dept Nutr & Food Sci, Granada 18071, Spain.
C3 University of Granada; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEROBN; University of Granada
RP Tur, JA (corresponding author), Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Tur, JA (corresponding author), Hlth Inst Balearic Isl IDISBA, Palma De Mallorca 07120, Spain.; Tur, JA (corresponding author), Inst Salud Carlos III ISCIII, CIBEROBN Physiopathol Obes & Nutr CB12 03 30038, Madrid 28029, Spain.
EM javiercondepipo@gmail.com; cristina.bouzas@uib.es; mariscal@ugr.es;
   pep.tur@uib.es
RI Bouzas, Cristina/AAE-2069-2019; Tur, Josep/AAE-5748-2020;
   Mariscal-Arcas, Miguel/R-3406-2019; Tur, Josep/F-5576-2014; Conde Pipo,
   Javier/AAH-4848-2020; Mariscal-Arcas, Miguel/K-4150-2017
OI Bouzas Velasco, Cristina/0000-0002-1407-8461; Tur,
   Josep/0000-0002-6940-0761; Conde Pipo, Javier/0000-0003-0646-4044;
   Mariscal-Arcas, Miguel/0000-0001-9852-4950
FU European Regional Development Fund [CB12/03/30038]; IdISBa grant
   (FOLIUM); IdISBa grant (PRIMUS); IdISBa grant (SYNERGIA); IdISBa grant
   (LIBERI)
FX Instituto de Salud Carlos III through CIBEROBN CB12/03/30038, which is
   cofunded by the European Regional Development Fund. Other funding
   received: IdISBa grants (FOLIUM, PRIMUS, SYNERGIA, and LIBERI). The
   funding sponsors had no role in the design of the study; in the
   collection, analyses, or interpretation of the data; in the writing of
   the manuscript; or in the decision to publish the results.
CR ALONSO J, 1995, MED CLIN-BARCELONA, V104, P771
   [Anonymous], 2015, Tablas de Composicion de Alimentos, Guia de Practicas (Spanish Food Com-Position Tables)
   Bouaziz W, 2017, ARCH GERONTOL GERIAT, V69, P110, DOI 10.1016/j.archger.2016.10.012
   Carroll S, 2004, SPORTS MED, V34, P371, DOI 10.2165/00007256-200434060-00004
   Chien MY, 2010, PHYS THER, V90, P1277, DOI 10.2522/ptj.20090322
   Chung PK, 2017, ARCH GERONTOL GERIAT, V68, P44, DOI 10.1016/j.archger.2016.08.007
   Daimiel L, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-59458-6
   Jiménez-García JD, 2019, INT J SPORTS MED, V40, P116, DOI 10.1055/a-0787-1548
   Davies KAB, 2019, THER ADV ENDOCRINOL, V10, DOI 10.1177/2042018819888824
   Brito LVD, 2014, ARCH GERONTOL GERIAT, V59, P367, DOI 10.1016/j.archger.2014.05.010
   Medrano-Ureña MD, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17176343
   Dziegielewska-Gesiak S, 2021, CLIN INTERV AGING, V16, P1057, DOI 10.2147/CIA.S306982
   Engin A, 2017, ADV EXP MED BIOL, V960, P1, DOI 10.1007/978-3-319-48382-5_1
   Fernández-Ballarth JD, 2010, BRIT J NUTR, V103, P1808, DOI 10.1017/S0007114509993837
   Fernández-Bergés D, 2012, REV ESP CARDIOL, V65, P241, DOI [10.1016/j.recesp.2011.10.015, 10.1016/j.rec.2011.10.017]
   Foscolou A, 2018, EXP GERONTOL, V110, P35, DOI 10.1016/j.exger.2018.05.008
   Gallardo-Alfaro L, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16183358
   Gillison FB, 2009, SOC SCI MED, V68, P1700, DOI 10.1016/j.socscimed.2009.02.028
   Goodman JM, 2011, APPL PHYSIOL NUTR ME, V36, pS14, DOI [10.1139/h11-048, 10.1139/H11-048]
   Greco A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020634
   Hsiao MY, 2018, CLIN REHABIL, V32, P473, DOI 10.1177/0269215517730117
   Joseph MS, 2019, DIABET METAB SYND OB, V12, P2395, DOI 10.2147/DMSO.S211776
   Knapik A, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000015984
   Koster A, 2008, J AM GERIATR SOC, V56, P636, DOI 10.1111/j.1532-5415.2007.01632.x
   Ma WY, 2013, DIABETES CARE, V36, P1660, DOI 10.2337/dc12-1452
   Meadows R, 2020, DISABIL REHABIL, V42, P1101, DOI 10.1080/09638288.2018.1516815
   Milanovic Z, 2013, CLIN INTERV AGING, V8, DOI 10.2147/CIA.S44112
   Monserrat-Mesquida M, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9030236
   Myers J, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071652
   Nawrocka A, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16060972
   Nawrocka A, 2017, ANN AGR ENV MED, V24, P632, DOI 10.5604/12321966.1231388
   Ostman C, 2017, CARDIOLOGY, V136, P79, DOI 10.1159/000448088
   Pucci G, 2017, PHARMACOL RES, V120, P34, DOI 10.1016/j.phrs.2017.03.008
   Rijk L, 2020, J ORTHOP, V22, P135, DOI 10.1016/j.jor.2020.03.021
   Rikli RE, 1999, J AGING PHYS ACTIV, V7, P129, DOI 10.1123/japa.7.2.129
   Rosique-Esteban N, 2019, CLIN NUTR, V38, P1324, DOI 10.1016/j.clnu.2018.05.023
   Sánchez-Villegas A, 2002, EUR J NUTR, V41, P249, DOI 10.1007/s00394-002-0382-2
   Serrano-Sánchez JA, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0219798
   Shigematsu R, 2006, AGING CLIN EXP RES, V18, P242
   Stanghelle B, 2018, BMC MUSCULOSKEL DIS, V19, DOI 10.1186/s12891-018-2021-y
   Stokes AC, 2020, SSM-POPUL HLTH, V12, DOI 10.1016/j.ssmph.2020.100644
   Sunde S, 2021, EUR GERIATR MED, V12, P1247, DOI 10.1007/s41999-021-00525-0
   Sureda A, 2018, NUTRIENTS, V10, DOI 10.3390/nu10010062
   Topolski TD, 2006, Preventing Chronic Disease, V3, pA118
   Trichopoulou A, 2003, NEW ENGL J MED, V348, P2599, DOI 10.1056/NEJMoa025039
   van den Bogaard L, 2016, EUR SOCIOL REV, V32, P295, DOI 10.1093/esr/jcv135
   Vega-Lopez Sonia, 2014, BMC Res Notes, V7, P29, DOI 10.1186/1756-0500-7-29
   Vilagut G, 2008, MED CLIN-BARCELONA, V130, P726, DOI 10.1157/13121076
   World Health Organizatin, 2020, WHO guidelines on physical activity and sedentary behaviour
NR 49
TC 7
Z9 7
U1 1
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2022
VL 14
IS 9
AR 1798
DI 10.3390/nu14091798
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA 1E7HQ
UT WOS:000794655200001
PM 35565767
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yao, K
   Bian, C
   Zhao, X
AF Yao, Kui
   Bian, Ce
   Zhao, Xia
TI Association of polycystic ovary syndrome with metabolic syndrome and
   gestational diabetes: Aggravated complication of pregnancy (Review)
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE polycystic ovary syndrome; hyperinsulinemia; cytochrome p450-c17
   alpha-hydroxylase; functional ovarian hyperandrogenism; metabolic
   syndrome; gestational diabetes
ID INSULIN-RESISTANCE; SYNDROME PCOS; DIAGNOSTIC-CRITERIA; ANDROGEN EXCESS;
   WOMEN; HYPERANDROGENISM; PREVALENCE; METFORMIN; MELLITUS; OUTCOMES
AB Polycystic ovary syndrome (PCOS) affects 5-20% of the reproductive age women globally. PCOS is diagnosed by the presence of hyperandrogenism, oligo-anovulation, and polycystic morphology of at least one ovary. Insulin resistance (IR), hyperinsulinemia and associated metabolic abnormalities including metabolic syndrome play a significant role in the development of PCOS. The chances of developing MS in PCOS women was shown to increase by almost 14-fold in patients with increasing body mass index. Even in the absence of overt obesity, a preferential deposition of intra-abdominal fat is noted in PCOS women and this intra-abdominal fat leads to impaired insulin action and functional IR and hyperandrogenism. Functional ovarian hyperandrogenism of ovaries was suggested to be a consequence of IR, which activates androgen synthesizing enzyme, cytochrome p450-c17 alpha-hydroxylase, in ovarian theca cells and causes elevated oxidative stress accompanied by lower antioxidant status in ovaries, which contribute to PCOS pathogenesis. The elevated levels of luteinizing hormone that accompany the early stages of hyperandrogenemia, accelerate ovarian functional deterioration, which is further aggravated by hyperinsulinemia, in PCOS women. The risk of developing gestational diabetes in PCOS women is approximately three times greater, as compared to non-PCOS women, due to IR and hyperinsulinemia. Typical insulin-sensitizing drugs such as metformin, have been used to curtail IR and hyperinsulinemia in pregnant PCOS women, with varying results indicating the complexity of the disease and the need for better controlled studies and additional efforts for PCOS-specific drug discovery.
C1 [Yao, Kui; Bian, Ce; Zhao, Xia] Sichuan Univ, Minist Educ, Key Lab Birth Defects & Related Dis Women & Child, 20 Sect 3,South Renmin Rd, Chengdu 610042, Sichuan, Peoples R China.
   [Yao, Kui; Bian, Ce; Zhao, Xia] West China Second Univ Hosp, Chengdu, Sichuan, Peoples R China.
C3 Ministry of Education - China; Sichuan University
RP Zhao, X (corresponding author), Sichuan Univ, Minist Educ, Key Lab Birth Defects & Related Dis Women & Child, 20 Sect 3,South Renmin Rd, Chengdu 610042, Sichuan, Peoples R China.
EM rxbbjn@163.com
RI Yao, Kui/HGE-6416-2022
FU Scientific Research Project of Sichuan Medical Association [S16053]
FX This study was suppoted by Scientific Research Project of Sichuan
   Medical Association (S16053).
CR Abruzzese GA, 2017, HORM METAB RES, V49, P23, DOI 10.1055/s-0042-113463
   Amato MC, 2015, J ENDOCRINOL INVEST, V38, P1319, DOI 10.1007/s40618-015-0372-x
   [Anonymous], 2012, ACTA OBSTET GYNECOL, V91, P658
   Anttila L, 1998, OBSTET GYNECOL, V92, P13, DOI 10.1016/S0029-7844(98)00133-1
   Apridonidze T, 2005, J CLIN ENDOCR METAB, V90, P1929, DOI 10.1210/jc.2004-1045
   Azziz R, 2005, FERTIL STERIL, V83, P1343, DOI 10.1016/j.fertnstert.2005.01.085
   Azziz R, 2016, NAT REV DIS PRIMERS, V2, DOI 10.1038/nrdp.2016.57
   Azziz R, 2009, FERTIL STERIL, V91, P456, DOI 10.1016/j.fertnstert.2008.06.035
   Baptiste CG, 2010, J STEROID BIOCHEM, V122, P42, DOI 10.1016/j.jsbmb.2009.12.010
   BARBIERI RL, 1986, J CLIN ENDOCR METAB, V62, P904, DOI 10.1210/jcem-62-5-904
   Ben-Haroush A, 2004, DIABETIC MED, V21, P103, DOI 10.1046/j.1464-5491.2003.00985.x
   Bhattacharya SM, 2010, GYNECOL ENDOCRINOL, V26, P516, DOI 10.3109/09513590903367010
   Bil E, 2016, J OBSTET GYNAECOL RE, V42, P837, DOI 10.1111/jog.12985
   Bjercke S, 2002, GYNECOL OBSTET INVES, V54, P94, DOI 10.1159/000067719
   CARA JF, 1988, ENDOCRINOLOGY, V123, P733, DOI 10.1210/endo-123-2-733
   Carmina E, 2006, EUR J ENDOCRINOL, V154, P141, DOI 10.1530/eje.1.02058
   Codner E, 2007, J CLIN ENDOCR METAB, V92, P1209, DOI 10.1210/jc.2006-2641
   Colilla S, 2001, J CLIN ENDOCR METAB, V86, P2027, DOI 10.1210/jc.86.5.2027
   Costello MF, 2003, FERTIL STERIL, V79, P1, DOI 10.1016/S0015-0282(02)04554-5
   de Zegher F, 2009, TRENDS ENDOCRIN MET, V20, P418, DOI 10.1016/j.tem.2009.06.003
   Diamanti-Kandarakis E, 2012, ENDOCR REV, V33, P981, DOI 10.1210/er.2011-1034
   Dumesic DA, 2016, J CLIN ENDOCR METAB, V101, P4178, DOI 10.1210/jc.2016-2586
   Dumesic DA, 2015, ENDOCR REV, V36, P487, DOI 10.1210/er.2015-1018
   DUNAIF A, 1989, DIABETES, V38, P1165, DOI 10.2337/diabetes.38.9.1165
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Ehrmann DA, 2006, J CLIN ENDOCR METAB, V91, P48, DOI 10.1210/jc.2005-1329
   Ehrmann DA, 2004, AM J PHYSIOL-ENDOC M, V287, pE241, DOI 10.1152/ajpendo.00475.2003
   EHRMANN DA, 1992, NEW ENGL J MED, V327, P157, DOI 10.1056/NEJM199207163270304
   Facchinetti F, 2015, EUR J OBSTET GYN R B, V195, P72, DOI 10.1016/j.ejogrb.2015.09.024
   Fauser BCJM, 2012, FERTIL STERIL, V97, P28, DOI 10.1016/j.fertnstert.2011.09.024
   Ford ES, 2004, ATHEROSCLEROSIS, V173, P309, DOI 10.1016/j.atherosclerosis.2003.12.022
   FUTTERWEIT W, 1986, J CLIN ENDOCR METAB, V62, P16, DOI 10.1210/jcem-62-1-16
   Glueck CJ, 2002, FERTIL STERIL, V77, P520, DOI 10.1016/S0015-0282(01)03202-2
   Glueck CJ, 2002, HUM REPROD, V17, P2858, DOI 10.1093/humrep/17.11.2858
   González F, 2006, J CLIN ENDOCR METAB, V91, P336, DOI 10.1210/jc.2005-1696
   Homburg R, 2006, BEST PRACT RES CL EN, V20, P281, DOI 10.1016/j.beem.2006.03.009
   Jakubowicz DJ, 2002, J CLIN ENDOCR METAB, V87, P524, DOI 10.1210/jc.87.2.524
   Kauffman RP, 2006, FERTIL STERIL, V85, P1010, DOI 10.1016/j.fertnstert.2005.09.046
   Legro RS, 2015, J CLIN ENDOCR METAB, V100, P4048, DOI 10.1210/jc.2015-2778
   Madani T, 2016, ARCH ENDOCRIN METAB, V60, P199, DOI 10.1590/2359-3997000000135
   Soares EMM, 2008, FERTIL STERIL, V89, P649, DOI 10.1016/j.fertnstert.2007.03.081
   Mannerås-Holm L, 2011, J CLIN ENDOCR METAB, V96, pE304, DOI 10.1210/jc.2010-1290
   Moghetti P, 2013, J CLIN ENDOCR METAB, V98, pE628, DOI 10.1210/jc.2012-3908
   Nawaz FH, 2008, J OBSTET GYNAECOL RE, V34, P832, DOI 10.1111/j.1447-0756.2008.00856.x
   Nisenblat V, 2009, CURR OPIN ENDOCRINOL, V16, P224, DOI 10.1097/MED.0b013e32832afd4d
   Polak K, 2017, J ENDOCRINOL INVEST, V40, P1, DOI 10.1007/s40618-016-0523-8
   Qin JZ, 2013, REPROD BIOL ENDOCRIN, V11, DOI 10.1186/1477-7827-11-56
   Rodrigues JK, 2015, HUM REPROD, V30, P664, DOI 10.1093/humrep/deu335
   ROSENFIELD RL, 1990, FERTIL STERIL, V53, P785
   ROSENFIELD RL, 1972, J CLIN ENDOCR METAB, V34, P92, DOI 10.1210/jcem-34-1-92
   Rosenfield RL, 2016, ENDOCR REV, V37, P467, DOI 10.1210/er.2015-1104
   Rossi B, 2008, J CLIN ENDOCR METAB, V93, P4780, DOI 10.1210/jc.2008-1198
   Stepto NK, 2013, HUM REPROD, V28, P777, DOI 10.1093/humrep/des463
   Suresh S, 2015, INDIAN J CLIN BIOCHE, V30, P345, DOI 10.1007/s12291-014-0447-z
   Turhan NÖ, 2003, INT J GYNECOL OBSTET, V81, P163, DOI 10.1016/S0020-7292(03)00003-1
   Turkmen S, 2016, OBES SURG, V26, P111, DOI 10.1007/s11695-015-1729-0
   Unger RH, 2010, BBA-MOL CELL BIOL L, V1801, P209, DOI 10.1016/j.bbalip.2009.10.006
   Vural B, 2005, HUM REPROD, V20, P2409, DOI 10.1093/humrep/dei100
   Weerakiet S, 2004, GYNECOL ENDOCRINOL, V19, P134, DOI 10.1080/09513590400007242
   Wu S, 2014, DIABETES, V63, P1270, DOI 10.2337/db13-1514
NR 60
TC 35
Z9 45
U1 0
U2 4
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD AUG
PY 2017
VL 14
IS 2
BP 1271
EP 1276
DI 10.3892/etm.2017.4642
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FB7BY
UT WOS:000406297300054
PM 28810587
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Mehran, L
   Amouzegar, A
   Rahimabad, PK
   Tohidi, M
   Tahmasebinejad, Z
   Azizi, F
AF Mehran, Ladan
   Amouzegar, Atieh
   Rahimabad, Parnian Kheirkhah
   Tohidi, Maryam
   Tahmasebinejad, Zhale
   Azizi, Fereidoun
TI Thyroid Function and Metabolic Syndrome: A Population-Based Thyroid
   Study
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE metabolic syndrome; thyroid; hypothyroidism; hyperthyroidism
ID DENSITY-LIPOPROTEIN CHOLESTEROL; STIMULATING HORMONE-LEVELS; C-REACTIVE
   PROTEIN; INSULIN-RESISTANCE; OXIDATIVE STRESS; ASSOCIATION; DISEASE;
   TSH; HYPOTHYROIDISM; SENSITIVITY
AB The impact of thyroid dysfunction in subclinical ranges on metabolic syndrome (MetS) is not well known. The aim of the present study is to evaluate the association of thyroid dysfunction with MetS and its components. In the cross-sectional population-based Tehran Thyroid Study, out of 5 786 randomly selected participants, aged >= 20 years, subjects with thyroid nodules and cancer or any severe systemic disease, those who were pregnant and those using thyroid medication were excluded, leaving 5422 subjects to be investigated. Body weight, waist circumference, and blood pressure were measured. Fasting blood glucose and concentrations of lipids and lipoproteins, free T4, and TSH were assayed. Mean age of the participants was 40.3 +/- 14.4 of whom 101 (2 %) had overt hypothyroidism, 294 (5 %) subclinical hypothyroidism, 82 (2 %) overt hyperthyroidism, and 178 (3 %) had subclinical hyperthyroidism; 1 704 (32 %) had MetS. Clinically hypothyroid subjects had the highest prevalence of MetS (41.6 %), abdominal obesity (45 %), and hypertriglyceridemia (58 %) compared to other groups (p < 0.05). Significant odds ratio for prevalent MetS was observed only in clinically hypothyroid men [OR: 2.9, 95 % CI: 1.04, 8.4, p = 0.04]. In women, the association between overt hypothyroidism and MetS was marginally significant only in the crude model [OR: 0.068, 95 % CI (0.97-2.42), p = 0.06]. There was higher risk of Mets in subclinically hypothyroid subjects, aged > 50. Overt and subclinical hyperthyroidism had significantly higher odds of hyperglycemia in men and women after full adjustment for age, smoking, and BMI. Overt hypothyroidism and subclinical hypothyroidism especially in the elderly could be associated with MetS. Hyperthyroidism may induce hyperglycemia.
C1 [Mehran, Ladan; Amouzegar, Atieh; Rahimabad, Parnian Kheirkhah; Tahmasebinejad, Zhale; Azizi, Fereidoun] Shahid Beheshti Univ Med Sci, Endocrine Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
   [Tohidi, Maryam] Shahid Beheshti Univ Med Sci, Prevent Metab Disorders Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences
RP Azizi, F (corresponding author), Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Res Ctr, Internal Med & Endocrinol, POB 19395 4763, Tehran, Iran.
EM azizi@endocrine.ac.ir
RI Tohidi, Maryam/V-2261-2019; Amouzegar, Atieh/K-1551-2017; Azizi,
   Fereidoun/ABD-4136-2021
OI amouzegar, atieh/0000-0003-1046-0003; Amouzegar,
   Atieh/0000-0001-9433-9408; Azizi, Fereidoun/0000-0002-6470-2517
FU Research Institute of Endocrine Sciences, Shahid Beheshti University of
   Medical Sciences, Tehran, I. R. Iran
FX The project supported by Research Institute of Endocrine Sciences,
   Shahid Beheshti University of Medical Sciences, Tehran, I. R. Iran. We
   would like to acknowledge the personnel of the laboratory of Research
   Institute for Endocrine Sciences for their collaboration and assistance.
   We also thank Ms. Niloofar Shiva for editing the manuscript.
CR ABRAMS JJ, 1981, J LIPID RES, V22, P307
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Amouzegar A, 2015, DIABETES METAB, V41, P480, DOI 10.1016/j.diabet.2015.04.004
   Amouzegar A, 2013, J ENDOCRINOL INVEST, V36, P950, DOI 10.3275/9033
   Azizi F, 2013, ARCH IRAN MED, V16, P418, DOI 013167/AIM.0011
   Azizi F, 2010, ARCH IRAN MED, V13, P243
   Azizi F, 2009, TRIALS, V10, DOI 10.1186/1745-6215-10-5
   COULOMBE P, 1976, METABOLISM, V25, P973, DOI 10.1016/0026-0495(76)90126-8
   Garduño-Garcia JD, 2010, EUR J ENDOCRINOL, V163, P273, DOI 10.1530/EJE-10-0312
   Delshad H, 2012, THYROID, V22, P415, DOI 10.1089/thy.2011.0156
   Dimitriadis G, 2005, HORM METAB RES, V37, P15, DOI 10.1055/s-2005-861026
   DIMITRIADIS G, 1985, AM J PHYSIOL, V248, pE593, DOI 10.1152/ajpendo.1985.248.5.E593
   Dimitriadis G, 2006, J CLIN ENDOCR METAB, V91, P4930, DOI 10.1210/jc.2006-0478
   Duntas LH, 2002, THYROID, V12, P287, DOI 10.1089/10507250252949405
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   FEEK CM, 1980, J CLIN ENDOCR METAB, V51, P585, DOI 10.1210/jcem-51-3-585
   FERRANNINI E, 1991, DIABETOLOGIA, V34, P416, DOI 10.1007/BF00403180
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   Geer EB, 2009, GENDER MED, V6, P60, DOI 10.1016/j.genm.2009.02.002
   GUYTON AC, 1981, CIRCULATION, V64, P1079, DOI 10.1161/01.CIR.64.6.1079
   Heima NE, 2013, EUR J ENDOCRINOL, V168, P59, DOI 10.1530/EJE-12-0375
   Ittermann T, 2012, J CLIN ENDOCR METAB, V97, P828, DOI 10.1210/jc.2011-2768
   Iwen KA, 2013, EUR THYROID J, V2, P83, DOI 10.1159/000351249
   Jenkins RC, 2000, CLIN ENDOCRINOL, V52, P187, DOI 10.1046/j.1365-2265.2000.00924.x
   Kitahara CM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034979
   Lai YX, 2011, ENDOCR J, V58, P23, DOI 10.1507/endocrj.K10E-272
   LAM KSL, 1986, Q J MED, V59, P513
   Lear SA, 2003, METABOLISM, V52, P1542, DOI 10.1016/j.metabol.2003.07.005
   Lee Yeo Kyung, 2011, Korean Journal of Internal Medicine, V26, P432, DOI 10.3904/kjim.2011.26.4.432
   Liu YY, 2010, TRENDS ENDOCRIN MET, V21, P166, DOI 10.1016/j.tem.2009.11.004
   Maratou E, 2010, EUR J ENDOCRINOL, V163, P625, DOI 10.1530/EJE-10-0246
   Muscogiuri G, 2013, OBESITY, V21, P101, DOI 10.1002/oby.20240
   Oh JY, 2013, KOREAN J INTERN MED, V28, P180, DOI 10.3904/kjim.2013.28.2.180
   Reinehr T, 2008, HORM RES, V70, P51, DOI 10.1159/000129678
   Rossi IA, 2012, EUR J EPIDEMIOL, V27, P379, DOI 10.1007/s10654-012-9671-0
   Santi A, 2010, CLIN CHEM LAB MED, V48, P1635, DOI 10.1515/CCLM.2010.309
   Souza AD, 2011, EUR J ENDOCRINOL, V165, P11, DOI 10.1530/EJE-11-0261
   Stanická S, 2005, CLIN CHEM LAB MED, V43, P715, DOI 10.1515/CCLM.2005.121
   Tancevski I, 2008, ENDOCRINOLOGY, V149, P3708, DOI 10.1210/en.2007-1387
   Thvilum M, 2013, J CLIN ENDOCR METAB, V98, P1069, DOI 10.1210/jc.2012-3375
   van de Ven AC, 2011, J CLIN ENDOCR METAB, V96, pE2014, DOI 10.1210/jc.2011-0680
   Visser WE, 2009, J CLIN ENDOCR METAB, V94, P3487, DOI 10.1210/jc.2009-0782
   Wang CY, 2012, ENDOCR J, V59, P911, DOI 10.1507/endocrj.EJ12-0076
   Waring AC, 2012, CLIN ENDOCRINOL, V76, P911, DOI 10.1111/j.1365-2265.2011.04328.x
   Welt CK, 2004, NEW ENGL J MED, V351, P987, DOI 10.1056/NEJMoa040388
   Yavuz DG, 2004, CLIN ENDOCRINOL, V61, P515, DOI 10.1111/j.1365-2265.2004.02123.x
   Zhu XG, 2010, CURR OPIN ENDOCRINOL, V17, P408, DOI 10.1097/MED.0b013e32833d6d46
NR 47
TC 57
Z9 61
U1 0
U2 27
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD MAR
PY 2017
VL 49
IS 3
BP 192
EP 200
DI 10.1055/s-0042-117279
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EQ7GA
UT WOS:000398251300006
PM 28351085
DA 2025-06-11
ER

PT J
AU Lee, G
   Yang, SJ
   Chee, YK
AF Lee, Guna
   Yang, Sook Ja
   Chee, Yeon Kyung
TI Assessment of healthy behaviors for metabolic syndrome among Korean
   adults: a modified information-motivation-behavioral skills with
   psychological distress
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Metabolic syndrome; Healthy behavior; Information-motivation-behavioral
   skills model (IMB); Psychological Distress
ID LIFE-STYLE; SOCIAL SUPPORT; SELF-EFFICACY; KNOWLEDGE; RISK; PREDICTION;
   EDUCATION; OUTCOMES; STRESS; WOMEN
AB Background: Since the worldwide incidence of metabolic syndrome (Mets) has rapidly increased, healthy behaviors such as weight control, engaging in physical activity, and healthy diet have been crucial in the management of Mets. The purpose of this study was to examine healthy behaviors practice and factors that affect the practice in relation to Mets on the basis of a modified Information-Motivation-Behavioral skills model (IMB) with psychological distress, which is a well-known factor affecting healthy behaviors among individuals with Mets.
   Methods: Study participants were 267 community dwelling adults (M-age: 54.0 +/- 8.1 years) with Mets who were attending public health centers located in Seoul, South Korea. A structured questionnaire was administered in the areas of information, motivation, behavioral skills, and practice of Mets healthy behaviors and levels of psychological distress from May 2014 to September 2014. Structural equation modeling was used to test the modified IMB model.
   Results: The modified IMB model had a good fit with the data, indicating that motivation and behavioral skills directly influenced the practice of Mets healthy behaviors, whereas information and psychological distress directly influenced motivation and influenced the practice of healthy behaviors through behavioral skills. These components of the modified IMB model explained 29.8 % of the variance in healthy behaviors for Mets.
   Conclusion: Findings suggested that strengthening motivation and behavioral skills for healthy behaviors can directly enhance healthy behavior practice. Providing information about Mets related healthy behaviors and strategies for psychological distress management can be used as the first line evidence based intervention to systemically enhance motivation and behavioral skills among individuals with Mets.
C1 [Lee, Guna; Yang, Sook Ja] Ewha Womans Univ, Coll Nursing, Seoul, South Korea.
   [Chee, Yeon Kyung] Ewha Womans Univ, Dept Child Dev, Seoul, South Korea.
C3 Ewha Womans University; Ewha Womans University
RP Yang, SJ (corresponding author), Ewha Womans Univ, Coll Nursing, Seoul, South Korea.
EM yangsj@ewha.ac.kr
CR AJZEN I, 1991, ORGAN BEHAV HUM DEC, V50, P179, DOI 10.1016/0749-5978(91)90020-T
   AJZEN I, 1986, J EXP SOC PSYCHOL, V22, P453, DOI 10.1016/0022-1031(86)90045-4
   Alberti G., 2006, The IDF consensus worldwide definition of the metabolic syndrome
   강세원, 2010, [The Journal of Fundamentals of Nursing, 기본간호학회지], V17, P487
   [Anonymous], 1999, Definition, diagnosis and classification of diabetes mellitus and its complications Report of a WHO consultation Geneva, P31
   [Anonymous], 2012, ARTERIOSCLER THROMB, DOI DOI 10.1161/ATVBAHA.111.241919
   [Anonymous], 2005, KOREAN PUBLIC HLTH R
   [Anonymous], 1996, J Korean Acad Fam Med
   Backman DR, 2002, J NUTR EDUC BEHAV, V34, P184, DOI 10.1016/S1499-4046(06)60092-4
   Bagozzi R.P., 1988, Journal of Academy of marketing science, V16, P74, DOI [10.1007/BF02723327, DOI 10.1007/BF02723327, 10.1177/009207038801600107]
   Becker H., 1993, HLTH VALUES, V17, P42
   Björntorp P, 2001, SCAND CARDIOVASC J, V35, P172, DOI 10.1080/140174301750305045
   Bollen K. A., 1989, STRUCTURAL EQUATIONS, DOI DOI 10.1002/9781118619179
   Bull S, 2006, J ADV NURS, V54, P585, DOI 10.1111/j.1365-2648.2006.03861.x
   Chen AMH, 2014, RES SOC ADMIN PHARM, V10, P378, DOI 10.1016/j.sapharm.2013.07.001
   Choi SH, 2015, NUTR RES PRACT, V9, P150, DOI 10.4162/nrp.2015.9.2.150
   Dalle Grave R, 2010, DIABET METAB SYND OB, V3, P373, DOI 10.2147/DMSOTT.S13860
   Bezares-Sarmiento VD, 2013, NUTR HOSP, V28, P1195, DOI 10.3305/nh.2013.28.4.6518
   Ellis DA, 2010, J DEV BEHAV PEDIATR, V31, P461, DOI 10.1097/DBP.0b013e3181e35337
   FISHER JD, 1992, PSYCHOL BULL, V111, P455, DOI 10.1037/0033-2909.111.3.455
   Fisher WA, 2003, BLACKW SER HLTH PSYC, P82, DOI 10.1002/9780470753552.ch4
   Foreyt JP, 2005, AM J CARDIOL, V96, p11E, DOI 10.1016/j.amjcard.2005.05.009
   FORNELL C, 1981, J MARKETING RES, V18, P39, DOI 10.2307/3151312
   Francis J., 2004, Constructing questionnaires based on the theory of planned behaviour: A manual for health services researchers
   FRANK SH, 1988, J FAM PRACTICE, V26, P533
   Frisman GH, 2008, NURS HEALTH SCI, V10, P300, DOI 10.1111/j.1442-2018.2008.00418.x
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   GLANZ K, 1981, MED CARE, V19, P141, DOI 10.1097/00005650-198102000-00002
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Grundy Scott M, 2004, J Am Coll Cardiol, V44, P720, DOI 10.1016/j.jacc.2004.07.001
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Helgason AR, 2004, EUR J PUBLIC HEALTH, V14, P306, DOI 10.1093/eurpub/14.3.306
   Isomaa B, 2003, LIFE SCI, V73, P2395, DOI 10.1016/S0024-3205(03)00646-5
   KELLY RB, 1991, SOC SCI MED, V32, P311, DOI 10.1016/0277-9536(91)90109-P
   Kim Chun Ja, 2010, [Korean Journal of Adult Nursing, 성인간호학회지], V22, P51
   Kudo Y, 2011, IND HEALTH, V49, P365, DOI 10.2486/indhealth.MS1172
   Lin CH, 2014, WORLDV EVID-BASED NU, V11, P361, DOI 10.1111/wvn.12069
   McKenzie SH, 2013, BMC FAM PRACT, V14, DOI 10.1186/1471-2296-14-166
   MECHANIC D, 1980, PREV MED, V9, P805, DOI 10.1016/0091-7435(80)90023-7
   Mohebi Siamak, 2014, J Educ Health Promot, V3, P21, DOI 10.4103/2277-9531.127608
   Murer M, 2012, SWISS MED WKLY, V142, DOI 10.4414/smw.2012.13691
   Newcomer JW, 1998, ARCH GEN PSYCHIAT, V55, P995, DOI 10.1001/archpsyc.55.11.995
   Oh Eui-Geum, 2007, Taehan Kanho Hakhoe Chi, V37, P790
   김유진, 2012, Journal of Obesity & Metabolic Syndrome, V21, P108, DOI 10.7570/kjo.2012.21.2.108
   Parker WA, 2011, PUBLIC HEALTH NUTR, V14, P1429, DOI 10.1017/S1368980009993272
   Pender N J, 1988, Cardiovasc Nurs, V24, P41
   Poston WSC, 2000, AM FAM PHYSICIAN, V61, P3615
   Seeman TE, 2000, AM J HEALTH PROMOT, V14, P362, DOI 10.4278/0890-1171-14.6.362
   STRECHER VJ, 1986, HEALTH EDUC QUART, V13, P73, DOI 10.1177/109019818601300108
   Sturt Jackie, 2006, BMC Fam Pract, V7, P70, DOI 10.1186/1471-2296-7-70
   Sullivan VK, 2006, J AM DIET ASSOC, V106, P668, DOI 10.1016/j.jada.2006.03.027
   Trouillet R, 2009, AGING MENT HEALTH, V13, P357, DOI 10.1080/13607860802626223
   Yamaoka K, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-138
NR 53
TC 21
Z9 23
U1 1
U2 25
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD JUN 18
PY 2016
VL 16
AR 518
DI 10.1186/s12889-016-3185-8
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA DO7PO
UT WOS:000377974700001
PM 27317425
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jeong, SK
   Kim, YK
   Park, JW
   Shin, YJ
   Kim, DS
AF Jeong, Seul-Ki
   Kim, Young-Kon
   Park, Jin-Woo
   Shin, Yong-Ju
   Kim, Dal-Sik
TI Impact of Visceral Fat on the Metabolic Syndrome and Nonalcoholic Fatty
   Liver Disease
SO JOURNAL OF KOREAN MEDICAL SCIENCE
LA English
DT Article
DE Nonalcoholic Fatly Liver Disease; Metabolic Syndrome; Intra-Abdominal
   Fat; Work Index
ID RISK-FACTORS; INSULIN-RESISTANCE; HEPATIC STEATOSIS; PHYSICAL-ACTIVITY;
   OXIDATIVE STRESS; PREVALENCE; DIAGNOSIS; OBESITY
AB Visceral fat has been reported to be associated with nonalcoholic fatty liver disease (NAFLD) and the metabolic syndrome (MetS). We assessed the prevalence of both NAFLD and the MetS, measured visceral fat thickness (VFT), and estimated the physical activity indexes of 224 relatively healthy hospital workers. We also investigated the associations between both VFT and physical activity index and each of NAFLD and the MetS. The MetS was diagnosed according to the guidelines outlined by the Adult Treatment Panel III, and NAFLD was diagnosed by ultrasonography. Subjects with hepatitis B and C infections and those reporting moderate alcohol consumption were excluded from the study. The prevalence of the MetS was 11.6% and that of NAFLD was 41.5%. Many subjects with the MetS had NAFLD (73.1%), and some subjects with NAFLD (20.4%) also had several components of the MetS (p=0.001). VFT was significantly increased by both the addition of components of the MetS and the severity of NAFLD (p < 0.001). In addition, VFT was independently associated with NAFLD (odds ratio [OR], 1.10; 95% confidence interval [CI], 1.02-1.19) in subjects with more than 2 components of the MetS. In contrast, habitual physical activity was reversely associated with NAFLD (OR, 0.29; 95% Cl, 0.10-0.87). In conclusion, an increased visceral fat content and reduced physical activity could be not only biological markers but also therapeutic targets in the treatment of NAFLD and the MetS.
C1 [Kim, Dal-Sik] Chonbuk Natl Univ, Sch Med, Dept Lab Med, Jeonju 561180, South Korea.
   [Jeong, Seul-Ki] Chonbuk Natl Univ, Sch Med, Dept Neurol, Jeonju, South Korea.
   [Kim, Young-Kon] Chonbuk Natl Univ, Sch Med, Dept Diagnost Radiol, Jeonju, South Korea.
   [Park, Jin-Woo] Chonbuk Natl Univ, Sch Med, Dept Biochem, Jeonju, South Korea.
   [Shin, Yong-Ju] Catholic Med Ctr, Dept Internal Med, Seoul, South Korea.
C3 Jeonbuk National University; Jeonbuk National University; Jeonbuk
   National University; Jeonbuk National University
RP Kim, DS (corresponding author), Chonbuk Natl Univ, Sch Med, Dept Lab Med, San 2-20 Geumam Dong, Jeonju 561180, South Korea.
EM dskim@chonbuk.ac.kr
RI Park, Jinwoo/AAD-1328-2022; Jeong, Seul-Ki/KSL-7574-2024
OI Jeong, Seul-Ki/0000-0002-9868-621X
FU Korean Stroke Society Young Investigator's Award [KSS-2006-002]
FX This work was supported in pan by a grant from the Korean Stroke Society
   Young Investigator's Award (KSS-2006-002).We, the authors, would like to
   extend special thanks to Cho MH and Lee JH, and Kim JH for their
   valuable assistance in the study processes and preparation of this
   manuscript. This work was Supported In part by a grant from the Korean
   Stroke Society Young Investigator's Award (KSS2006-002).
CR Andrade S, 2002, AM J CLIN NUTR, V75, P587, DOI 10.1093/ajcn/75.3.587
   BAECKE JAH, 1982, AM J CLIN NUTR, V36, P936
   Banfi C, 1999, CIRC RES, V85, P208, DOI 10.1161/01.RES.85.2.208
   Barzilai N, 1999, DIABETES, V48, P94, DOI 10.2337/diabetes.48.1.94
   Bedogni G, 2005, HEPATOLOGY, V42, P44, DOI 10.1002/hep.20734
   Bedogni Giorgio, 2004, Ann Hepatol, V3, P63
   Bellentani S, 2000, ANN INTERN MED, V132, P112, DOI 10.7326/0003-4819-132-2-200001180-00004
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   DURNIN JVGA, 1974, BRIT J NUTR, V32, P77, DOI 10.1079/BJN19740060
   Ford ES, 2005, OBES RES, V13, P608, DOI 10.1038/oby.2005.65
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hamaguchi M, 2005, ANN INTERN MED, V143, P722, DOI 10.7326/0003-4819-143-10-200511150-00009
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jeong SK, 2005, J KOREAN MED SCI, V20, P7, DOI 10.3346/jkms.2005.20.1.7
   Jeong SK, 2004, INT J OBESITY, V28, P1033, DOI 10.1038/sj.ijo.0802698
   Kim DS, 2007, BIOCHEM BIOPH RES CO, V363, P140, DOI 10.1016/j.bbrc.2007.08.151
   KIM SY, 2007, J KOREAN ACAD FAM ME, V28, P667
   Laaksonen DE, 2002, AM J EPIDEMIOL, V156, P1070, DOI 10.1093/aje/kwf145
   Lee CW, 1992, J KOREAN PUB HLTH AS, V18, P38
   LEE WG, 2003, KOREAN J LAB MED, V23, P363
   Marchesini G, 2003, HEPATOLOGY, V37, P917, DOI 10.1053/jhep.2003.50161
   O'Leary VB, 2006, J APPL PHYSIOL, V100, P1584, DOI 10.1152/japplphysiol.01336.2005
   Onat A, 2002, ATHEROSCLEROSIS, V165, P285, DOI 10.1016/S0021-9150(02)00236-8
   QUINN SF, 1985, AM J ROENTGENOL, V145, P753, DOI 10.2214/ajr.145.4.753
   Roskams T, 2003, AM J PATHOL, V163, P1301, DOI 10.1016/S0002-9440(10)63489-X
   Saadeh S, 2002, GASTROENTEROLOGY, V123, P745, DOI 10.1053/gast.2002.35354
   Samuel VT, 2004, J BIOL CHEM, V279, P32345, DOI 10.1074/jbc.M313478200
   Sanyal Arun J, 2002, Gastroenterology, V123, P1705, DOI 10.1053/gast.2002.36572
   Targher G, 2005, DIABETIC MED, V22, P1354, DOI 10.1111/j.1464-5491.2005.01646.x
   Woo J, 1999, EUR J CLIN NUTR, V53, P461, DOI 10.1038/sj.ejcn.1600777
   YAJIMA Y, 1983, TOHOKU J EXP MED, V139, P43, DOI 10.1620/tjem.139.43
NR 32
TC 26
Z9 34
U1 0
U2 0
PU KOREAN ACAD MEDICAL SCIENCES
PI SEOUL
PA 302 75 DONG DU ICHON, DONG YONGSAN KU, SEOUL 140 031, SOUTH KOREA
SN 1011-8934
EI 1598-6357
J9 J KOREAN MED SCI
JI J. Korean Med. Sci.
PD OCT
PY 2008
VL 23
IS 5
BP 789
EP 795
DI 10.3346/jkms.2008.23.5.789
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 369WP
UT WOS:000260724900007
PM 18955783
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Laurindo, LF
   Rodrigues, VD
   Minniti, G
   de Carvalho, ACA
   Zutin, TLM
   Deliberto, LK
   Bishayee, A
   Barbalho, SM
AF Laurindo, Lucas Fornari
   Rodrigues, Victoria Dogani
   Minniti, Giulia
   de Carvalho, Antonelly Cassio Alves
   Zutin, Tereza Lais Menegucci
   Deliberto, Lindsay K.
   Bishayee, Anupam
   Barbalho, Sandra Maria
TI Pomegranate ( Punica granatum L.) phytochemicals target the components
   of metabolic syndrome
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Review
DE Punica granatum L.; Pomegranate; Metabolic syndrome; Diabetes;
   Hypertension; Dyslipidemia; Obesity
ID ELLAGIC ACID; SEED OIL; FRUIT EXTRACT; GALLIC ACID; ANTIMICROBIAL
   ACTIVITY; INSULIN-RESISTANCE; JUICE CONSUMPTION; OXIDATIVE STRESS; RAT
   MODEL; ANTIOXIDANT
AB Pomegranate (Punica granatum L.) is a multipurpose dietary and medicinal plant known for its ability to promote various health benefits. Metabolic syndrome (MetS) is a complex metabolic disorder driving health and socioeconomic challenges worldwide. It may be characterized by insulin resistance, abdominal obesity, hypertension, and dyslipidemia. This study aims to conduct a review of pomegranate's effects on MetS parameters using a mechanistic approach relying on pre -clinical studies. The peel, juice, roots, bark, seeds, flowers, and leaves of the fruit present several bioactive compounds that are related mainly to anti-inflammatory and antioxidant activities as well as cardioprotective, antidiabetic, and antiobesity effects. The use of the juice extract can work as a potent inhibitor of angiotensin-converting enzyme activities, consequently regulating blood pressure. The major bioactive compounds found within the fruit are phenolic compounds (hydrolysable tannins and flavonoids) and fatty acids. Alkaloids, punicalagin, ellagitannins, ellagic acid, anthocyanins, tannins, flavonoids, luteolin, and punicic acid are also present. The antihyperglycemia, antihyperlipidemia, and weight loss promoting effects are likely related to the anti-inflammatory and antioxidant effects. When considering clinical application, pomegranate extracts are found to be frequently well -tolerated, further supporting its efficacy as a treatment modality. We suggest that pomegranate fruit, extract, or processed products can be used to counteract MetS-related risk factors. This review represents an important step towards exploring potential avenues for further research in this area. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Laurindo, Lucas Fornari; Rodrigues, Victoria Dogani] Fac Med Marilia FAMEMA, Sch Med, Dept Biochem & Pharmacol, Sao Paulo, SP, Brazil.
   [Laurindo, Lucas Fornari; Minniti, Giulia; de Carvalho, Antonelly Cassio Alves; Zutin, Tereza Lais Menegucci; Barbalho, Sandra Maria] Univ Marilia UNIMAR, Sch Med, Dept Biochem & Pharmacol, BR-17514844 Marilia, Sao Paulo, Brazil.
   [de Carvalho, Antonelly Cassio Alves; Zutin, Tereza Lais Menegucci; Barbalho, Sandra Maria] Univ Marilia UNIMAR, Postgrad Program Struct & Funct Interact Rehabil, Sao Paulo, SP, Brazil.
   [Deliberto, Lindsay K.; Bishayee, Anupam] Lake Erie Coll Osteopath Med, Coll Osteopath Med, Dept Pharmacol, 5000 Lakewood Ranch Blvd, Bradenton, FL 34211 USA.
   [Barbalho, Sandra Maria] Sch Food & Technol Marilia FATEC, Dept Biochem & Nutr, Sao Paulo, SP, Brazil.
C3 Faculdade de Medicina de Marilia; Universidade de Marilia; Universidade
   de Marilia
RP Barbalho, SM (corresponding author), Univ Marilia UNIMAR, Sch Med, Dept Biochem & Pharmacol, BR-17514844 Marilia, Sao Paulo, Brazil.; Bishayee, A (corresponding author), Lake Erie Coll Osteopath Med, Coll Osteopath Med, Dept Pharmacol, 5000 Lakewood Ranch Blvd, Bradenton, FL 34211 USA.
EM abishayee@gmail.com; smbarbalho@gmail.com
RI FORNARI LAURINDO, LUCAS/HZJ-7263-2023; barbalho, sandra/Z-3515-2019;
   Bishayee, Anupam/G-4290-2012
OI FORNARI LAURINDO, LUCAS/0000-0003-3159-0982
CR Abbate M, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph181910333
   Abd-Elghany AA, 2023, ACS OMEGA, V8, P16620, DOI 10.1021/acsomega.2c07254
   Abedini M, 2021, PHYTOTHER RES, V35, P442, DOI 10.1002/ptr.6820
   Akaberi M, 2021, ADV EXP MED BIOL, V1328, P421, DOI 10.1007/978-3-030-73234-9_28
   Al-Dujaili EAS, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11112124
   Al-Muammar MN, 2012, NUTRITION, V28, P595, DOI 10.1016/j.nut.2011.11.013
   Alalawi S, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24108476
   Ali MY, 2023, J AGR FOOD CHEM, V71, P11476, DOI 10.1021/acs.jafc.3c02115
   AlMatar M, 2019, CURR PHARM BIOTECHNO, V20, P317, DOI 10.2174/1389201020666190308130343
   Almeda-Valdés P, 2009, ANN HEPATOL, V8, pS18, DOI 10.1016/S1665-2681(19)31822-8
   Amor AJ, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9121226
   Ansari P, 2022, LIFE-BASEL, V12, DOI 10.3390/life12081146
   Ansarimoghaddam A, 2018, DIABETES METAB SYND, V12, P195, DOI 10.1016/j.dsx.2017.11.004
   Asgary S, 2017, CURR PHARM DESIGN, V23, P1042, DOI 10.2174/1381612822666161010103339
   Aviram M, 2001, ATHEROSCLEROSIS, V158, P195, DOI 10.1016/S0021-9150(01)00412-9
   Ballantyne CM, 2008, INT J OBESITY, V32, pS21, DOI 10.1038/ijo.2008.31
   Banihani SA, 2014, NUTR RES, V34, P862, DOI 10.1016/j.nutres.2014.08.003
   Banihani S, 2013, NUTR RES, V33, P341, DOI 10.1016/j.nutres.2013.03.003
   Bankoski A, 2011, DIABETES CARE, V34, P497, DOI 10.2337/dc10-0987
   Bar-Ya'akov I, 2019, FRONT PLANT SCI, V10, DOI 10.3389/fpls.2019.00620
   Barghchi H, 2023, NUTR J, V22, DOI 10.1186/s12937-023-00869-2
   Baydemir Pe, 2023, J Chromatogr B Analyt Technol Biomed Life Sci, V1229
   Benedetti G, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12071351
   Bener Abdulbari, 2014, Indian J Endocrinol Metab, V18, P202, DOI 10.4103/2230-8210.129112
   BenSaad LA, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1555-0
   Binmowyna MN, 2021, FOOD SCI TECH-BRAZIL, V41, P732, DOI 10.1590/fst.31220
   Boden G, 2008, ENDOCRIN METAB CLIN, V37, P635, DOI 10.1016/j.ecl.2008.06.007
   Boldaji RB, 2020, J SCI FOOD AGR, V100, P846, DOI 10.1002/jsfa.10096
   Bolling BW, 2012, J FOOD SCI, V77, pH69, DOI 10.1111/j.1750-3841.2011.02538.x
   Bonomini F, 2015, AGING DIS, V6, P109, DOI 10.14336/AD.2014.0305
   Bovolini A, 2021, INT J SPORTS MED, V42, P199, DOI 10.1055/a-1263-0898
   Brighenti V, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22084175
   Caballero V, 2022, J AGR FOOD CHEM, V70, P16273, DOI 10.1021/acs.jafc.2c06585
   Espín JC, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/270418
   Cerdá B, 2003, EUR J NUTR, V42, P18, DOI 10.1007/s00394-003-0396-4
   Chan KL, 2019, PHYSIOLOGY, V34, P123, DOI 10.1152/physiol.00047.2018
   Chen P, 2023, J INTEGR NEUROSCI, V22, DOI 10.31083/j.jin2205113
   Chen P, 2023, PHYTOTHER RES, V37, P3655, DOI 10.1002/ptr.7848
   Chen PF, 2022, MOL MED, V28, DOI 10.1186/s10020-022-00444-1
   Chen SJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0045693
   Cheng F, 2021, ONCOTARGETS THER, V14, P3199, DOI 10.2147/OTT.S305595
   Cheshomi H, 2022, HUM EXP TOXICOL, V41, DOI 10.1177/09603271211064534
   Cisneros-Zevallos L, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21062086
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Colic M, 2022, MOLECULES, V27, DOI 10.3390/molecules27227871
   Colombo E, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/247145
   Cortés-Martín A, 2021, MOL NUTR FOOD RES, V65, DOI 10.1002/mnfr.202001048
   Cortez-Trejo MC, 2022, BIOMOLECULES, V12, DOI 10.3390/biom12111649
   Pinheiro AJMCR, 2018, J IMMUNOL RES, V2018, DOI 10.1155/2018/6879183
   Cumpston M, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.ED000142
   D'Amico D, 2021, TRENDS MOL MED, V27, P687, DOI 10.1016/j.molmed.2021.04.009
   Dai Z, 2010, ONCOL REP, V24, P1087, DOI 10.3892/or_00000959
   Das S, 2012, INDIAN J PHARMACOL, V44, P219, DOI 10.4103/0253-7613.93853
   Davila EP, 2010, DIABETES CARE, V33, P2390, DOI 10.2337/dc10-0681
   de Ferranti SD, 2004, CIRCULATION, V110, P2494, DOI 10.1161/01.CIR.0000145117.40114.C7
   de Kloet AD, 2010, PHYSIOL BEHAV, V100, P525, DOI 10.1016/j.physbeh.2010.03.018
   De Nigris F, 2007, NITRIC OXIDE-BIOL CH, V17, P50, DOI 10.1016/j.niox.2007.04.005
   Delgado NTB, 2017, FRONT PHARMACOL, V7, DOI 10.3389/fphar.2016.00522
   Dey D, 2015, PHARM BIOL, V53, P1474, DOI 10.3109/13880209.2014.986687
   Djedjibegovic J, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/5194508
   dos Santos RL, 2016, J TOXICOL ENV HEAL A, V79, P998, DOI 10.1080/15287394.2016.1213690
   Eghbali S, 2021, J NUTR METAB, V2021, DOI 10.1155/2021/5297162
   Ehteshami S, 2020, J FOOD BIOCHEM, V44, DOI 10.1111/jfbc.13393
   El Moujahed S, 2021, WASTE BIOMASS VALORI, V12, P5383, DOI 10.1007/s12649-021-01413-1
   EL-Aguel A, 2022, VIRUSES-BASEL, V14, DOI 10.3390/v14122639
   El-Demerdash FM, 2023, TISSUE CELL, V85, DOI 10.1016/j.tice.2023.102227
   El-Hadary AE, 2019, J FOOD BIOCHEM, V43, DOI 10.1111/jfbc.12803
   Esmaeilinezhad Z, 2020, J ENDOCRINOL INVEST, V43, P539, DOI 10.1007/s40618-019-01139-x
   Esmael OA, 2015, TOXICOL IND HEALTH, V31, P281, DOI 10.1177/0748233712472526
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Farmanfarma KK, 2019, DIABETES METAB SYND, V13, P792, DOI 10.1016/j.dsx.2018.11.055
   Fleming DS, 2023, MOLECULES, V28, DOI 10.3390/molecules28217369
   Forouzanfar F, 2022, MEDIAT INFLAMM, V2022, DOI 10.1155/2022/6850342
   Friend A, 2013, METAB SYNDR RELAT D, V11, P71, DOI 10.1089/met.2012.0122
   Gava R, 2023, MEAT SCI, V202, DOI 10.1016/j.meatsci.2023.109198
   Ge GR, 2022, SCI CHINA LIFE SCI, V65, P588, DOI 10.1007/s11427-020-1939-1
   Gelen V, 2023, IRAN J BASIC MED SCI, V26, P1326, DOI 10.22038/IJBMS.2023.71343.15525
   Gharib E, 2019, IRAN J PHARM RES, V18, P358
   Golbidi S, 2014, J DIABETES RES, V2014, DOI 10.1155/2014/726861
   González-Ortiz M, 2011, ANN NUTR METAB, V58, P220, DOI 10.1159/000330116
   Guerra JVS, 2021, NUTRIENTS, V13, DOI 10.3390/nu13082830
   Guerra-Vázquez CM, 2022, FOODS, V11, DOI 10.3390/foods11030252
   Gull H, 2023, FOOD SCI NUTR, V11, P7188, DOI 10.1002/fsn3.3644
   Gupta A, 2021, ADV NUTR, V12, P1211, DOI 10.1093/advances/nmab007
   Habib HM, 2023, NUTRIENTS, V15, DOI 10.3390/nu15122709
   Hadrich F, 2014, J OLEO SCI, V63, P515, DOI 10.5650/jos.ess13163
   Hamrita B, 2022, IRAN J MICROBIOL, V14, P373, DOI 10.18502/ijm.v14i3.9778
   Harakeh S, 2020, SAUDI J BIOL SCI, V27, P3474, DOI 10.1016/j.sjbs.2020.09.060
   Hashemi M, 2010, CARDIOL YOUNG, V20, P73, DOI 10.1017/S1047951109990850
   Hasona NA, 2016, MERIT RES J MED MED, V4, P196
   Hayden MR, 2023, MEDICINA-LITHUANIA, V59, DOI 10.3390/medicina59030561
   Heber D, Herbal medicine: biomolecular and clinical aspects
   Heber D, 2007, J AGR FOOD CHEM, V55, P10050, DOI 10.1021/jf071689v
   Hernández-Rubio A, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-06010-3
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Hosseini A, 2023, PHYTOMEDICINE, V109, DOI 10.1016/j.phymed.2022.154581
   Hosseini B, 2016, COMPLEMENT THER CLIN, V22, P44, DOI 10.1016/j.ctcp.2015.12.003
   Hosseini SA, 2023, FRONT PHARMACOL, V14, DOI 10.3389/fphar.2023.1109966
   Hossin F, 2009, Pakistan Journal of Nutrition, V8
   Hou C, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201800773
   Howell AB, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/606212
   Huang THW, 2005, BRIT J PHARMACOL, V145, P767, DOI 10.1038/sj.bjp.0706245
   Jghef MM, 2023, CHEM-BIOL INTERACT, V385, DOI 10.1016/j.cbi.2023.110745
   Kam A, 2013, PHYTOTHER RES, V27, P1614, DOI 10.1002/ptr.4913
   Kandylis P, 2020, FOODS, V9, DOI 10.3390/foods9020122
   Kang I, 2016, MOL NUTR FOOD RES, V60, P1129, DOI 10.1002/mnfr.201500796
   Khadivi A, 2020, SCI HORTIC-AMSTERDAM, V264, DOI 10.1016/j.scienta.2019.109165
   Khajebishak Y, 2019, J CELL PHYSIOL, V234, P2112, DOI 10.1002/jcp.27556
   Kostka T, 2020, FOODS, V9, DOI 10.3390/foods9111617
   Ky I., 2016, Encyclopedia of Food and Health, P247, DOI [10.1016/B978-0-12-384947-2.00683-8, DOI 10.1016/B978-0-12-384947-2.00683-8]
   Laaraj N, 2022, FOODS, V11, DOI 10.3390/foods11091353
   Lansky EP, 2005, INVEST NEW DRUG, V23, P121, DOI 10.1007/s10637-005-5856-7
   Laurindo LF, 2022, NUTRIENTS, V14, DOI 10.3390/nu14081665
   Lee HJ, 2021, CELL DEATH DIFFER, V28, P184, DOI 10.1038/s41418-020-0593-1
   Lei F, 2007, INT J OBESITY, V31, P1023, DOI 10.1038/sj.ijo.0803502
   Les F, 2018, J ETHNOPHARMACOL, V220, P67, DOI 10.1016/j.jep.2018.03.029
   Li H, 2023, Healthcare (Basel), V45, P97
   Li R, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-2870-y
   Li T, 2020, BIOMED PHARMACOTHER, V131, DOI 10.1016/j.biopha.2020.110769
   Li ZJ, 2017, PHYTOTHER RES, V31, P1039, DOI 10.1002/ptr.5823
   Liu HD, 2017, CANCER BIOL THER, V18, P990, DOI 10.1080/15384047.2017.1394542
   Long JF, 2019, FOOD FUNCT, V10, P6582, DOI [10.1039/c9fo01683j, 10.1039/C9FO01683J]
   Lu GY, 2023, BIOMED PHARMACOTHER, V165, DOI 10.1016/j.biopha.2023.115132
   Machado M, 2022, MOLECULES, V27, DOI 10.3390/molecules27154958
   Magangana TP, 2020, Molecules, V26, P1054
   Majeed Z, Hypotensive action of pomegranate seed extract and zinc chloride in hypertensive rats2019
   Makino-Wakagi Y, 2012, BIOCHEM BIOPH RES CO, V417, P880, DOI 10.1016/j.bbrc.2011.12.067
   Manickam V, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.888300
   Mannino F, 2023, BIOMED PHARMACOTHER, V162, DOI 10.1016/j.biopha.2023.114666
   Mansoor K, 2023, MOLECULES, V28, DOI 10.3390/molecules28052117
   Maphetu N, 2022, BIOMED PHARMACOTHER, V153, DOI 10.1016/j.biopha.2022.113256
   Marra F, 2022, MOLECULES, V27, DOI 10.3390/molecules27175555
   Mathieu P, 2006, VASC HEALTH RISK MAN, V2, P285, DOI 10.2147/vhrm.2006.2.3.285
   McFarlin BK, 2009, BRIT J NUTR, V102, P54, DOI 10.1017/S0007114508159001
   Medjakovic S, 2013, FOOD FUNCT, V4, P19, DOI 10.1039/c2fo30034f
   Meerts IATM, 2009, FOOD CHEM TOXICOL, V47, P1085, DOI 10.1016/j.fct.2009.01.031
   Melgarejo-Sánchez P, 2021, BIORESOUR BIOPROCESS, V8, DOI 10.1186/s40643-020-00351-5
   Mertens-Talcott SU, 2006, J AGR FOOD CHEM, V54, P8956, DOI 10.1021/jf061674h
   Michicotl-Meneses MM, 2021, NUTRIENTS, V13, DOI 10.3390/nu13082577
   Moazzen H, 2017, PLANT FOOD HUM NUTR, V72, P126, DOI 10.1007/s11130-017-0605-6
   Möller K, 2023, ENDOSC ULTRASOUND, V12, P213, DOI 10.4103/EUS-D-22-00162
   Moga MA, 2021, MOLECULES, V26, DOI 10.3390/molecules26041054
   Mohammadi M, 2023, IRAN J BASIC MED SCI, V26, P1245, DOI 10.22038/IJBMS.2023.72816.15844
   Mohammadi M, 2017, REP BIOCHEM MOL BIOL, V6, P74
   Mohan M, 2010, J PHARMACOL PHARMACO, V1, P32, DOI 10.4103/0976-500X.64533
   Mohan M, 2010, PHYTOTHER RES, V24, pS196, DOI 10.1002/ptr.3090
   Monika P, 2023, BMC COMPLEMENT MED, V23, DOI 10.1186/s12906-023-03993-y
   Mosleh G, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.624006
   Myagmar-Ochir Enkhtuguldur, 2023, Int J Environ Res Public Health, V20, DOI 10.3390/ijerph20064956
   Naghipour M, 2021, INT J ENDOCRINOL, V2021, DOI 10.1155/2021/8862456
   Nasr Mohamed, 2023, J Exp Pharmacol, V15, P191, DOI 10.2147/JEP.S404321
   Nekooeian AA, 2014, IRAN J MED SCI, V39, P130
   Nichols GA, 2023, METAB SYNDR RELAT D, V21, P261, DOI 10.1089/met.2023.0006
   Noda Y, 2002, J AGR FOOD CHEM, V50, P166, DOI 10.1021/jf0108765
   Noor U, 2022, Recent Adv Food Nutr Agric
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Osadnik K, 2023, EUR J PREV CARDIOL, DOI 10.1093/eurjpc/zwad101
   Palomo-Ligas L, 2022, PEERJ, V10, DOI 10.7717/peerj.13350
   Park HM, 2010, INT J DERMATOL, V49, P276, DOI 10.1111/j.1365-4632.2009.04269.x
   Patel C, 2008, FOOD CHEM TOXICOL, V46, P2728, DOI 10.1016/j.fct.2008.04.035
   Peppoloni S, 2022, MICROORGANISMS, V10, DOI 10.3390/microorganisms10122500
   Pierdomenico M, 2024, NAT PROD RES, V38, P727, DOI 10.1080/14786419.2023.2196622
   Pottathil S, 2020, PLANTS-BASEL, V9, DOI 10.3390/plants9111609
   Prasetyastuti Prasetyastuti, 2014, Pakistan Journal of Nutrition, V13, P567
   Rafati S, 2021, DIABETOL METAB SYNDR, V13, DOI 10.1186/s13098-021-00737-1
   Rahimi HR, 2012, IRAN J PHARM RES, V11, P385
   Razani Z, 2017, PHYTOTHER RES, V31, P1731, DOI 10.1002/ptr.5901
   Reisinger C, 2021, INT J OBESITY, V45, P12, DOI 10.1038/s41366-020-00713-1
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   Rivadeneyra-Domínguez E, 2023, CHILDREN-BASEL, V10, DOI 10.3390/children10030473
   Rivara MB, 2015, J RENAL NUTR, V25, P40, DOI 10.1053/j.jrn.2014.07.006
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Rogovskii VS, 2022, CURR CANCER DRUG TAR, V22, P717, DOI 10.2174/1568009622666220602125343
   Rosas-Burgos EC, 2017, J SCI FOOD AGR, V97, P802, DOI 10.1002/jsfa.7799
   Rouhi SZT, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1667-6
   Sadeghipour A, 2014, EVID-BASED COMPL ALT, V2014, DOI 10.1155/2014/432650
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Salim A, 2023, J BIORESOUR BIOPROD, V8, P146, DOI 10.1016/j.jobab.2023.01.006
   Saltiel AR, 2017, J CLIN INVEST, V127, P1, DOI [10.1172/JCI92035, 10.1172/jci92035]
   Sanchez-Lamar A, 2008, J ETHNOPHARMACOL, V115, P416, DOI 10.1016/j.jep.2007.10.011
   Sanna C, 2021, PLANTS-BASEL, V10, DOI 10.3390/plants10102124
   Sarkhosh A., 2023, Food Chem. Adv., V2, DOI [DOI 10.1016/J.FOCHA.2023.100225, 10.1016/j.focha.2023.100225]
   Sayed S, 2022, LIFE-BASEL, V12, DOI 10.3390/life12020224
   Sayed-Ahmed EF., 2014, INT J NUTR FOOD SCI, V3, P411, DOI [10.11648/j.ijnfs.20140305.18, DOI 10.11648/J.IJNFS.20140305.18]
   Seeram NP, 2004, CLIN CHIM ACTA, V348, P63, DOI 10.1016/j.cccn.2004.04.029
   Shao JY, 2016, AM J CHINESE MED, V44, P785, DOI 10.1142/S0192415X16500439
   Sharifi-Rad J, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/3848084
   Sharma P, 2017, MOLECULES, V22, DOI 10.3390/molecules22010177
   Sharma P, 2011, INDIAN J CLIN BIOCHE, V26, P317, DOI 10.1007/s12291-011-0175-6
   Shema-Didi L, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-18
   Rossi JLS, 2022, DIABETES-METAB RES, V38, DOI 10.1002/dmrr.3502
   Singh J, 2023, ACS OMEGA, V8, P35452, DOI 10.1021/acsomega.3c02586
   Soltaninejad M, 2020, WORK, V67, P829, DOI 10.3233/WOR-203335
   Srivastav SK, 2022, PATHOPHYSIOLOGY-BASE, V29, P319, DOI 10.3390/pathophysiology29020023
   Subkorn P, 2021, PEERJ, V9, DOI 10.7717/peerj.12303
   Suliga E, 2015, NUTR J, V14, DOI 10.1186/s12937-015-0045-9
   Sun K, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047791
   Sun WY, 2016, SCI REP-UK, V6, DOI 10.1038/srep34246
   Swiatkiewicz I, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010221
   Thambiah SC, 2023, MALAYS J PATHOL, V45, P97
   Thangavelu A, 2017, J PHARM BIOALLIED SC, V9, pS11, DOI 10.4103/jpbs.JPBS_101_17
   Tiwari P, 2022, Functional foods and nutraceuticals in metabolic and non-communicable diseases, P121
   Toney AM, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9020192
   Tsang C, 2012, J NUTR SCI, V1, DOI 10.1017/jns.2012.10
   Valdenegro M, 2022, FRONT PLANT SCI, V13, DOI 10.3389/fpls.2022.771094
   Valero-Mendoza A. G., 2023, Food Chemistry Advances, V2, P100153, DOI 10.1016/j.focha.2022.100153
   Vidal A, 2003, J ETHNOPHARMACOL, V89, P295, DOI 10.1016/j.jep.2003.09.001
   Viladomiu M, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/789764
   Vizmanos B, 2023, OBESITY, V31, P1227, DOI 10.1002/oby.23765
   Vroegrijk IOCM, 2011, FOOD CHEM TOXICOL, V49, P1426, DOI 10.1016/j.fct.2011.03.037
   Wang L, 2014, CARCINOGENESIS, V35, P2321, DOI 10.1093/carcin/bgu145
   Wang YJ, 2018, KOREAN J PHYSIOL PHA, V22, P409, DOI 10.4196/kjpp.2018.22.4.409
   Wang YQ, 2024, PHYTOTHER RES, V38, P713, DOI 10.1002/ptr.8071
   Widyawati R, 2023, OPEN VET J, V13, P466, DOI 10.5455/OVJ.2023.v13.i4.8
   Wofford Marion R, 2006, J Clin Hypertens (Greenwich), V8, P114, DOI 10.1111/j.1524-6175.2006.04751.x
   Wong TL, 2021, SEMIN CANCER BIOL, V73, P265, DOI 10.1016/j.semcancer.2021.01.006
   Wu S, 2017, MOLECULES, V22, DOI 10.3390/molecules22101606
   Wu S, 2019, NAT PROD RES, V33, P252, DOI 10.1080/14786419.2018.1446009
   Xia B, 2020, PLOS BIOL, V18, DOI 10.1371/journal.pbio.3000688
   Xu Y, 2021, MOLECULES, V26, DOI 10.3390/molecules26237115
   Yang L, 2021, J FOOD BIOCHEM, V45, DOI 10.1111/jfbc.13755
   Yisimayili Z, 2022, FOOD CHEM, V395, DOI 10.1016/j.foodchem.2022.133600
   Zhang JJ, 2018, J SEP SCI, V41, P540, DOI 10.1002/jssc.201700822
   Zhang XF, 2012, BIOORGAN MED CHEM, V20, P1616, DOI 10.1016/j.bmc.2011.11.040
   Zhang YZ, 2021, J ETHNOPHARMACOL, V272, DOI 10.1016/j.jep.2020.113628
   Zheng DP, 2020, CELL RES, V30, P492, DOI 10.1038/s41422-020-0332-7
   Zhu SK, 2004, METABOLISM, V53, P1503, DOI 10.1016/j.metabol.2004.04.017
   Ziolkowska S, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222011128
NR 228
TC 12
Z9 12
U1 7
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD SEP
PY 2024
VL 131
AR 109670
DI 10.1016/j.jnutbio.2024.109670
EA JUN 2024
PG 22
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA UZ8D7
UT WOS:001251969900001
PM 38768871
DA 2025-06-11
ER

PT J
AU Deng, ZZ
   Wu, N
   Wang, J
   Zhang, QB
AF Deng, Zhenzhen
   Wu, Ning
   Wang, Jing
   Zhang, Quanbin
TI Dietary fibers extracted from Saccharina japonica can improve metabolic
   syndrome and ameliorate gut microbiota dysbiosis induced by high fat
   diet
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Dietary fiber; Insulin resistance; Metabolic syndrome; Gut microbiota
ID INSULIN-RESISTANCE; HEALTH; MODULATION; CURCUMIN; FEATURES; OBESITY;
   LIVER; MODEL; MICE
AB Metabolic syndrome (MetS) is a pathological state of multiple metabolic abnormalities. Dietary fibers (DFs) has been widely concerned about its positive role in MetS. Different from the DFs of terrestrial plants, the DFs of seaweeds has unique composition and structural characteristics. The aim of this study is to investigate the composition and microstructures of DF derived from Saccharina japonica, and its positive effects on MetS mice induced by high fat diet (HFD). We extracted DF from S. japonica (DFSJ). DFSJ has a high proportion of soluble dietary fiber (SDF) and it shows good water holding capacity (11.34 +/- 1.63 g/g) and swelling property (32.9 +/- 2.52 mL/g). Supplementing DFSJ can significantly improve insulin resistance (IR), dyslipidemia in HFD mice. Besides, DFSJ can reduce inflammatory factors (TNF-alpha, MCP-1 and IL-6), improve the hepatic oxidative stress and protect visceral organs from the injury of HFD. Finally, 16S rDNA high-throughput sequencing was used to further analyze the profile changes of gut microbiota. The results indicated that supplementing DFSJ can effectively ameliorate gut microbiota dysbiosis. In particular, DFSJ can increase the relative abundance of some beneficial bacteria, such as Bifidobacterium, Turicibacter and Akkermansia. Our results indicated that DFSJ has a comprehensive regulatory effect on MetS, and it is involved in various regulatory pathways, such as antioxidant, anti-inflammatory, hypoglycemic and hypolipidemic pathways in HFD-induced MetS mice. Our results reveal the great potential of DFSJ as an effective regulator on various metabolic abnormalities of MetS.
C1 [Deng, Zhenzhen; Wu, Ning; Wang, Jing; Zhang, Quanbin] Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China.
   [Deng, Zhenzhen; Wang, Jing; Zhang, Quanbin] Qingdao Natl Lab Marine Sci & Tech, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China.
   [Deng, Zhenzhen] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
C3 Chinese Academy of Sciences; Institute of Oceanology, CAS; Laoshan
   Laboratory; Chinese Academy of Sciences; University of Chinese Academy
   of Sciences, CAS
RP Wang, J; Zhang, QB (corresponding author), Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China.; Wang, J; Zhang, QB (corresponding author), Qingdao Natl Lab Marine Sci & Tech, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China.
EM jingwang@qdio.ac.cn; qbzhang@qdio.ac.cn
RI Zhang, Quanbin/IUQ-3663-2023
FU National Key RD Plan of China [2018YFD0901104]; Special Open Fund of
   Laboratory for Marine Biology and Biotechnology, Qingdao Pilot National
   Laboratory for Marine Science and Technology [OF2020NO02]; Major
   Scientific & Engineering Projects of Innovation in Shandong Province
   [2019JZZY010818]; K.C. Wong Education Foundation, CAS
FX The research was supported by the National Key R&D Plan of China (Grant
   No. 2018YFD0901104) ; the Special Open Fund of Laboratory for Marine
   Biology and Biotechnology, Qingdao Pilot National Laboratory for Marine
   Science and Technology (No. OF2020NO02) ; Major Scientific & Engineering
   Projects of Innovation in Shandong Province (Grant No.2019JZZY010818) ,
   and K.C. Wong Education Foundation, CAS.
CR Aggarwal BB, 2010, ANNU REV NUTR, V30, P173, DOI 10.1146/annurev.nutr.012809.104755
   Ajila CM, 2007, FOOD CHEM, V102, P1006, DOI 10.1016/j.foodchem.2006.06.036
   Bian XY, 2020, MICROB BIOTECHNOL, V13, P1228, DOI 10.1111/1751-7915.13583
   Chen HH, 2019, J AGR FOOD CHEM, V67, P5278, DOI 10.1021/acs.jafc.9b01192
   Cornish ML, 2015, PHYCOLOGIA, V54, P649, DOI 10.2216/15-77.1
   Cui JF, 2019, COMPR REV FOOD SCI F, V18, P1514, DOI 10.1111/1541-4337.12489
   Davy BM, 2003, J AM DIET ASSOC, V103, P86, DOI 10.1053/jada.2003.50005
   Delzenne NM, 2020, CLIN NUTR, V39, P414, DOI 10.1016/j.clnu.2019.03.002
   Elleuch M, 2011, FOOD CHEM, V124, P411, DOI 10.1016/j.foodchem.2010.06.077
   Espinosa-Martos I, 2009, EUR FOOD RES TECHNOL, V228, P685, DOI 10.1007/s00217-008-0979-7
   Fernandez ML, 2001, CURR OPIN LIPIDOL, V12, P35, DOI 10.1097/00041433-200102000-00007
   Fraulob JC, 2010, J CLIN BIOCHEM NUTR, V46, P212, DOI 10.3164/jcbn.09-83
   Galisteo M, 2008, J NUTR BIOCHEM, V19, P71, DOI 10.1016/j.jnutbio.2007.02.009
   GIBSON GR, 1995, J NUTR, V125, P1401, DOI 10.1093/jn/125.6.1401
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   He QF, 2018, CELLULOSE, V25, P5523, DOI 10.1007/s10570-018-1966-1
   Holdt SL, 2011, J APPL PHYCOL, V23, P543, DOI 10.1007/s10811-010-9632-5
   Ji HY, 2019, J FOOD MEAS CHARACT, V13, P1574, DOI 10.1007/s11694-019-00073-z
   Jin DX, 2019, J FUNCT FOODS, V52, P479, DOI 10.1016/j.jff.2018.11.031
   Khanal RC, 2012, J MED FOOD, V15, P802, DOI 10.1089/jmf.2011.0212
   Kim JY, 2018, FRONT NUTR, V5, DOI 10.3389/fnut.2018.00023
   Kotronen A, 2008, ARTERIOSCL THROM VAS, V28, P27, DOI 10.1161/ATVBAHA.107.147538
   Lidfeldt J, 2003, DIABETES OBES METAB, V5, P106, DOI 10.1046/j.1463-1326.2003.00250.x
   Lin LY, 2015, FOOD FUNCT, V6, P1600, DOI [10.1039/C4FO00901K, 10.1039/c4fo00901k]
   Lorincz AM, 2006, ENDOCR-RELAT CANCER, V13, P279, DOI 10.1677/erc.1.00729
   Marinval N, 2016, MAR DRUGS, V14, DOI 10.3390/md14100185
   Martínez-Gómez F, 2016, CARBOHYD POLYM, V146, P90, DOI 10.1016/j.carbpol.2016.03.047
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mudgil D, 2013, INT J BIOL MACROMOL, V61, P1, DOI 10.1016/j.ijbiomac.2013.06.044
   Ottosson F, 2018, J CLIN ENDOCR METAB, V103, P1491, DOI 10.1210/jc.2017-02114
   Sun SS, 2019, CHIN J NAT MEDICINES, V17, P3, DOI 10.1016/S1875-5364(19)30003-2
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Velikonja A, 2019, ANAEROBE, V55, P67, DOI 10.1016/j.anaerobe.2018.11.002
   Villanueva-Millán MJ, 2015, J PHYSIOL BIOCHEM, V71, P509, DOI 10.1007/s13105-015-0390-3
   Wang CH, 2019, CURR TOP NUTRACEUT R, V17, P195
   Wang X, 2018, INT J BIOL MACROMOL, V115, P861, DOI 10.1016/j.ijbiomac.2018.04.042
   Wen Y, 2017, LWT-FOOD SCI TECHNOL, V75, P344, DOI 10.1016/j.lwt.2016.09.012
   Wikoff WR, 2009, P NATL ACAD SCI USA, V106, P3698, DOI 10.1073/pnas.0812874106
   Wu X, 2020, PHARMACOL RES, V158, DOI 10.1016/j.phrs.2020.104937
   Yang LN, 2020, J FOOD SCI TECH MYS, V57, P152, DOI 10.1007/s13197-019-04041-9
   Zimta AA, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20215364
NR 41
TC 18
Z9 20
U1 4
U2 49
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD OCT
PY 2021
VL 85
AR 104642
DI 10.1016/j.jff.2021.104642
EA JUL 2021
PG 11
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA UD0HZ
UT WOS:000686899700006
OA gold
DA 2025-06-11
ER

PT J
AU Alegbe, EO
   Terali, K
   Olofinsan, KA
   Surgun, S
   Ogbaga, CC
   Ajiboye, TO
AF Alegbe, Emmanuel Ohifueme
   Terali, Kerem
   Olofinsan, Kolawole Ayodapo
   Surgun, Serdar
   Ogbaga, Chukwuma Collins
   Ajiboye, Taofeek Olakunle
TI Antidiabetic activity-guided isolation of gallic and protocatechuic
   acids from Hibiscus sabdariffa calyxes
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE diabetes; gallic acid; glycosidase; Hibiscus sabdariffa; protocatechuic
   acid
ID CUMMINSII STAPF DIELS; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   DETOXIFICATION POTENTIALS; ALPHA-AMYLASE; HYPERGLYCEMIA; ANTIOXIDANT;
   L.; DYSLIPIDEMIA; EXTRACT
AB We isolated and identified gallic and protocatechuic acids as the antidiabetic principles in Hibiscus sabdariffa using solvent extraction, column chromatographic fractionation, and nuclear magnetic resonance (NMR) spectroscopy. Ethylacetate fraction of the aqueous extract of H. sabdariffa inhibited alpha-amylase and alpha-glucosidase with IC50 of 411.73 and 433.93 mu g/ml, respectively. Furthermore, fractions I and II obtained from column chromatography inhibited alpha-amylase with IC50 of 27.03 and 20.12 mu g/ml, and alpha-glucosidase with IC50 of 24.30 and 22.29 mu g/ml, respectively. In addition, the principles reduced the serum glucose and lipid peroxide levels of diabetic rats and with an improvement in the rat lipid profiles and antioxidant defenses. Fractions I and II were identified as protocatechuic acid and gallic acid, respectively, using H-1 and C-13 NMR. Protein-ligand docking showed that these compounds form multiple favorable interactions with the active-site residues of the two glycosidases. Overall, protocatechuic and gallic acids emerge as natural antidiabetic agents. Practical applications Hibiscus sabdariffa (Zoborodo) is a refreshment drink for ceremonial gatherings in Nigeria. Also, its pharmacological use includes diabetes, hypertension, hyperlipidemia, metabolic syndrome, and hepatoprotection. The consumption of this food drink could improve diabetes, hypertension, dyslipidemia, metabolic syndrome, and liver disease. Furthermore, the inhibition of alpha-amylase and alpha-glucosidase could prevent diabetic complications associated with postprandial glucose. Developing the extract of H. sabdariffa calyx as food supplement could be used in managing diabetes and its associated complications such as dyslipidemia, hypertension, and metabolic syndrome.
C1 [Alegbe, Emmanuel Ohifueme; Surgun, Serdar] Nile Univ Nigeria, Fac Nat & Appl Sci, Dept Chem, Abuja, Nigeria.
   [Terali, Kerem] Near East Univ, Dept Med Biochem, Fac Med, Nicosia, Cyprus.
   [Olofinsan, Kolawole Ayodapo] Nile Univ Nigeria, Fac Nat & Appl Sci, Dept Biochem, Abuja, Nigeria.
   [Ogbaga, Chukwuma Collins] Nile Univ Nigeria, Fac Nat & Appl Sci, Dept Biol Sci, Abuja, Nigeria.
   [Ogbaga, Chukwuma Collins] Nile Univ Nigeria, Fac Nat & Appl Sci, Dept Microbiol & Biotechnol, Abuja, Nigeria.
   [Ajiboye, Taofeek Olakunle] Nile Univ Nigeria, Dept Med Biochem, Coll Hlth Sci, Antioxidants Redox Biol & Toxicol Res Grp, Abuja, Nigeria.
C3 Near East University
RP Terali, K (corresponding author), Near East Univ, Dept Med Biochem, Fac Med, Nicosia, Cyprus.
EM kerem.terali@neu.edu.tr
RI Ajiboye, Taofeek/H-5383-2011; olofinsan, Kolawole/AAM-8402-2020; Ogbaga,
   Chukwuma/ABD-5384-2020; Terali, Kerem/Q-3270-2016
OI Surgun, Serdar/0009-0007-5215-9178; Terali, Kerem/0000-0002-9964-6383;
   olofinsan, kolawole/0000-0002-2987-0996
CR Ademiluyi AO, 2013, J MED FOOD, V16, P88, DOI 10.1089/jmf.2012.0004
   Adigun NS, 2016, S AFR J BOT, V105, P324, DOI 10.1016/j.sajb.2016.03.015
   Ajala-Lawal RA, 2020, ARCH PHYSIOL BIOCHEM, V126, P107, DOI 10.1080/13813455.2018.1498901
   Ajiboye TO, 2016, J ETHNOPHARMACOL, V192, P471, DOI 10.1016/j.jep.2016.08.024
   Ajiboye TO, 2016, J SCI FOOD AGR, V96, P1522, DOI 10.1002/jsfa.7254
   Ajiboye TO, 2014, J FOOD BIOCHEM, V38, P480, DOI 10.1111/jfbc.12080
   Ajiboye TO, 2014, J BIOCHEM MOL TOXIC, V28, P11, DOI 10.1002/jbt.21517
   Ajiboye TO, 2011, DRUG CHEM TOXICOL, V34, P109, DOI 10.3109/01480545.2010.536767
   [Anonymous], 2017, RECENT PROG MED PLAN
   [Anonymous], 2017, PAEDIAT CHILD HLTH O
   BEERS RF, 1952, J BIOL CHEM, V195, P133
   Berman HM, 2000, NUCLEIC ACIDS RES, V28, P235, DOI 10.1093/nar/28.1.235
   Caesar R, 2019, CAN J DIABETES, V43, P224, DOI 10.1016/j.jcjd.2019.01.007
   Cardona F, 2009, CHEM-EUR J, V15, P1627, DOI 10.1002/chem.200801578
   Cen Y, 2016, MOLECULES, V21, DOI 10.3390/molecules21091190
   Chandranath SI, 2002, CLIN EXP PHARMACOL P, V29, P173, DOI 10.1046/j.1440-1681.2002.03626.x
   Da-Costa-Rocha I, 2014, FOOD CHEM, V165, P424, DOI 10.1016/j.foodchem.2014.05.002
   Egan A.M., 2019, Science Direct, V47, P1, DOI [10.1016/j.mpmed.2018.10.002, DOI 10.1016/J.MPMED.2018.10.002]
   ELLMAN GL, 1959, ARCH BIOCHEM BIOPHYS, V82, P70, DOI 10.1016/0003-9861(59)90090-6
   Gandhi GR, 2014, EUR J PHARMACOL, V745, P201, DOI 10.1016/j.ejphar.2014.10.044
   Gondokesumo M.E., 2017, MOLEC CELL BIOMED SC, V1, P34, DOI [DOI 10.21705/MCBS.V1I1.3, 10.21705/mcbs.v1i1.3]
   Halim M, 2019, DIABETES METAB SYND, V13, P1165, DOI 10.1016/j.dsx.2019.01.040
   Harini R, 2010, REDOX REP, V15, P71, DOI 10.1179/174329210X12650506623285
   Huang DW, 2016, NUTR RES, V36, P150, DOI 10.1016/j.nutres.2015.10.001
   Ibitoye OB, 2020, DRUG CHEM TOXICOL, V43, P567, DOI 10.1080/01480545.2018.1523187
   Ibitoye OB, 2018, J FOOD BIOCHEM, V42, DOI 10.1111/jfbc.12587
   Ibitoye OB, 2018, J FOOD BIOCHEM, V42, DOI 10.1111/jfbc.12627
   Ibitoye OB, 2018, ARCH PHYSIOL BIOCHEM, V124, P410, DOI 10.1080/13813455.2017.1415938
   Ibitoye OB, 2018, J FOOD BIOCHEM, V42, DOI 10.1111/jfbc.12479
   Ighodaro OM, 2018, BIOMED PHARMACOTHER, V108, P656, DOI 10.1016/j.biopha.2018.09.058
   Irwin JJ, 2012, J CHEM INF MODEL, V52, P1757, DOI 10.1021/ci3001277
   Jabeur I, 2017, FOOD RES INT, V100, P717, DOI 10.1016/j.foodres.2017.07.073
   Jaiswal N, 2013, J DIABETES METAB, V4, DOI 10.4172/2155-6156.S6-004
   López-Martínez LM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0140242
   MISRA HP, 1972, J BIOL CHEM, V247, P3170
   Nahoum V, 2000, BIOCHEM J, V346, P201, DOI 10.1042/0264-6021:3460201
   Oboh G, 2016, J FOOD DRUG ANAL, V24, P627, DOI 10.1016/j.jfda.2016.03.003
   Oloyede HOB, 2015, J ETHNOPHARMACOL, V166, P313, DOI 10.1016/j.jep.2015.02.049
   Oloyede H. O. B., 2013, Food Bioscience, V1, P48
   Oloyede OB, 2014, J ETHNOPHARMACOL, V157, P309, DOI 10.1016/j.jep.2014.08.022
   Peng CH, 2011, J AGR FOOD CHEM, V59, P9901, DOI 10.1021/jf2022379
   Pettersen EF, 2004, J COMPUT CHEM, V25, P1605, DOI 10.1002/jcc.20084
   Punithavathi VR, 2011, EUR J PHARMACOL, V650, P465, DOI 10.1016/j.ejphar.2010.08.059
   Rains JL, 2011, FREE RADICAL BIO MED, V50, P567, DOI 10.1016/j.freeradbiomed.2010.12.006
   Rasheed DM, 2018, FOOD CHEM, V250, P236, DOI 10.1016/j.foodchem.2018.01.020
   Reilly C A, 2001, Curr Protoc Toxicol, VChapter 2, DOI 10.1002/0471140856.tx0204s00
   Roglic G, 2016, Global report on psoriasis
   Salentin S, 2015, NUCLEIC ACIDS RES, V43, pW443, DOI 10.1093/nar/gkv315
   Sánchez-Linares I, 2012, BMC BIOINFORMATICS, V13, DOI 10.1186/1471-2105-13-S14-S13
   Seung TW, 2018, FOOD RES INT, V105, P589, DOI 10.1016/j.foodres.2017.11.063
   Shadhan RM, 2017, ASIAN PAC J TROP BIO, V7, P466, DOI 10.1016/j.apjtb.2017.01.023
   Shalgum A, 2019, J HERB MED, V17-18, DOI 10.1016/j.hermed.2018.100253
   Su CC, 2018, J FUNCT FOODS, V48, P614, DOI 10.1016/j.jff.2018.07.032
   Su NN, 2018, J FUNCT FOODS, V43, P234, DOI 10.1016/j.jff.2018.02.017
   Tesfaye S., 2019, Medicine, V47, P92, DOI [10.1016/j.mpmed.2018.11.009, DOI 10.1016/J.MPMED.2018.11.009]
   Thomas S., 2019, MEDICINE, V47, P86, DOI [10.1016/j.mpmed.2018.11.010, DOI 10.1016/J.MPMED.2018.11.010]
   Zaki L. H., 2017, African Journal of Pharmacy and Pharmacology, V11, P161, DOI 10.5897/ajpp2017.4764
   Zaman A. G., 2019, MEDICINE, V47, P72, DOI [10.1016/j.mpmed.2018.11.012, DOI 10.1016/J.MPMED.2018.11.012]
   Zheoat AM, 2019, FITOTERAPIA, V134, P5, DOI 10.1016/j.fitote.2019.01.012
NR 59
TC 38
Z9 39
U1 1
U2 34
PU WILEY-HINDAWI
PI LONDON
PA ADAM HOUSE, 3RD FL, 1 FITZROY SQ, LONDON, WIT 5HE, ENGLAND
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD JUL
PY 2019
VL 43
IS 7
AR e12927
DI 10.1111/jfbc.12927
PG 12
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA IH2CS
UT WOS:000474303400044
PM 31353728
OA gold
DA 2025-06-11
ER

PT J
AU Elsamanoudy, AZ
   Abdalla, HA
   Hassanien, M
   Gaballah, MA
AF Elsamanoudy, Ayman Z.
   Abdalla, Hussein Abdelaziz
   Hassanien, Mohammed
   Gaballah, Mohammad A.
TI Spermatozoal cell death-inducing DNA fragmentation factor-α-like
   effector A (CIDEA) gene expression and DNA fragmentation in infertile
   men with metabolic syndrome and normal seminogram
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE CIDEA; Insulin genes expression; DNA fragmentation; Seminal glucose;
   Male infertility; Metabolic syndrome
ID HUMAN EJACULATED SPERMATOZOA; MALE REPRODUCTIVE FUNCTION; BODY-MASS
   INDEX; DIABETES-MELLITUS; OXIDATIVE STRESS; ADIPOSE-TISSUE;
   MALE-FERTILITY; INSULIN; OBESITY; SEMEN
AB Background: This is the first study to investigate spermatozoal cell death-inducing DNA fragmentation factor-a-like effector A (CIDEA) gene expression and DNA fragmentations in the spermatozoa of men diagnosed with metabolic syndrome (MS) who have normal seminograms with unexplained infertility, and to correlate these parameters with seminal glucose concentration.
   Methods: This study included 120 participants: 75 male subjects with MS (38 fertile and 37 infertile), and a control group of 45 fertile males without MS. HOMA-IR, semen analysis, and biochemical measurement of seminal plasma insulin and glucose levels were carried out. Spermatozoal insulin gene and CIDEA gene expressions were performed by the RT-PCR method. The percentage of spermatozoal DNA fragmentation was also estimated.
   Results: The spermatozoal insulin and CIDEA gene expression, as well as the DNA fragmentation, were significantly higher in the infertile MS group than in the fertile MS group, and significantly higher in both the MS groups than in the control group. Seminal glucose concentration showed significant positive correlations with seminal insulin level, spermatozoa insulin, CIDEA gene expression, and DNA fragmentation. Moreover, there was a positive correlation between spermatozoa CIDEA gene expression and DNA fragmentation.
   Conclusions: It can be concluded that MS may affect male fertility at the molecular level, through its possible inducing effect of spermatozoa CIDEA and insulin gene expression, DNA fragmentation, and increased seminal glucose.
C1 [Elsamanoudy, Ayman Z.; Abdalla, Hussein Abdelaziz] Mansoura Univ, Fac Med, Dept Med Biochem, Mansoura, Egypt.
   [Elsamanoudy, Ayman Z.; Hassanien, Mohammed] King Abdulaziz Univ, Fac Med, Dept Clin Biochem, Jeddah, Saudi Arabia.
   [Gaballah, Mohammad A.] Mansoura Univ, Fac Med, Dept Dermatol Androl & STDs, Mansoura, Egypt.
   [Hassanien, Mohammed] Tanta Univ, Fac Med, Dept Med Biochem, Tanta, Egypt.
C3 Egyptian Knowledge Bank (EKB); Mansoura University; King Abdulaziz
   University; Egyptian Knowledge Bank (EKB); Mansoura University; Egyptian
   Knowledge Bank (EKB); Tanta University
RP Elsamanoudy, AZ (corresponding author), Mansoura Univ, Fac Med, Dept Med Biochem, Mansoura, Egypt.; Elsamanoudy, AZ (corresponding author), King Abdulaziz Univ, Fac Med, Dept Clin Biochem, Jeddah, Saudi Arabia.
EM ayman.elsamanoudy@gmail.com
RI Abdalla, Hussein/AAB-7731-2022; gaballah, mohammad/AAO-8694-2020;
   Hassanien, Mohammed/B-7061-2012; Abdalla, Hussein Abdelaziz/M-6257-2018;
   Elsamanoudy, Ayman/M-6529-2018
OI Hassanien, Mohammed/0000-0001-6559-9710; Abdalla, Hussein
   Abdelaziz/0000-0002-2120-2651; gaballah, mohammad/0000-0001-6271-2511;
   Elsamanoudy, Ayman/0000-0002-8731-6184
CR Agbaje IM, 2007, HUM REPROD, V22, P1871, DOI 10.1093/humrep/dem077
   Aitken RJ, 2011, ASIAN J ANDROL, V13, P36, DOI 10.1038/aja.2010.68
   Aitken RJ, 2006, MOL CELL ENDOCRINOL, V250, P66, DOI 10.1016/j.mce.2005.12.026
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alves MG, 2013, BBA-MOL BASIS DIS, V1832, P626, DOI 10.1016/j.bbadis.2013.01.011
   Andò S, 2005, MOL CELL ENDOCRINOL, V245, P1, DOI 10.1016/j.mce.2005.09.011
   Aquila S, 2005, ENDOCRINOLOGY, V146, P552, DOI 10.1210/en.2004-1252
   Arow JP, 2010, J UROLOGY, V167, P2138
   Bhattacharya SM, 2014, J OBSTET GYNAECOL RE, V40, P167, DOI 10.1111/jog.12149
   Björndahl L, 2003, HUM REPROD, V18, P813, DOI 10.1093/humrep/deg199
   Chavarro JE, 2010, FERTIL STERIL, V93, P2222, DOI 10.1016/j.fertnstert.2009.01.100
   Chi Hee-Jun, 2011, Clin Exp Reprod Med, V38, P10, DOI 10.5653/cerm.2011.38.1.10
   Du Plessis SS, 2010, NAT REV UROL, V7, P153, DOI 10.1038/nrurol.2010.6
   Dupasquier S, 2014, BMC MOL BIOL, V15, DOI 10.1186/1471-2199-15-9
   Dupont C, 2013, ASIAN J ANDROL, V15, P622, DOI 10.1038/aja.2013.65
   ENDTZ AW, 1974, ACTA CYTOL, V18, P2
   Fariello RM, 2012, BJU INT, V110, P863, DOI 10.1111/j.1464-410X.2011.10813.x
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   GARCIADIEZ LC, 1991, ARCH ANDROLOGY, V26, P119, DOI 10.3109/01485019108987634
   Gummesson A, 2007, J CLIN ENDOCR METAB, V92, P4759, DOI 10.1210/jc.2007-1136
   Hammoud AO, 2008, FERTIL STERIL, V90, P897, DOI 10.1016/j.fertnstert.2008.08.026
   Henkel R, 2005, ANDROLOGIA, V37, P205, DOI 10.1111/j.1439-0272.2005.00699.x
   Hughes CM, 1999, MUTAGENESIS, V14, P71
   HWANG DL, 1985, HORM METAB RES, V17, P595, DOI 10.1055/s-2007-1013615
   Johansson LE, 2012, AM J CLIN NUTR, V96, P196, DOI 10.3945/ajcn.111.020578
   Juarez-Bengoa A, 2011, REV MEX UROL, V71, P87
   Kasturi SS, 2008, J ANDROL, V29, P251, DOI 10.2164/jandrol.107.003731
   La Vignera S, 2012, J ANDROL, V33, P145, DOI 10.2164/jandrol.111.013193
   Laurencikiene J, 2008, CANCER RES, V68, P9247, DOI 10.1158/0008-5472.CAN-08-1343
   Leisegang K, 2014, ANDROLOGIA, V46, P167, DOI 10.1111/and.12060
   Leisegang K, 2014, REPROD BIOL ENDOCRIN, V12, DOI 10.1186/1477-7827-12-34
   MacDonald AA, 2010, HUM REPROD UPDATE, V16, P293, DOI 10.1093/humupd/dmp047
   Mallidis C, 2009, INT J ANDROL, V32, P295, DOI 10.1111/j.1365-2605.2007.00849.x
   Mallidis C, 2011, REPRODUCTION, V142, P63, DOI 10.1530/REP-10-0472
   Marchetti P, 2012, ANDROLOGIA, V44, P136, DOI 10.1111/j.1439-0272.2010.01117.x
   Martínez P, 2007, ASIAN J ANDROL, V9, P102, DOI 10.1111/j.1745-7262.2007.00238.x
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Nordström EA, 2005, DIABETES, V54, P1726, DOI 10.2337/diabetes.54.6.1726
   Oleszczuk K, 2013, ANDROLOGY-US, V1, P357, DOI 10.1111/j.2047-2927.2012.00041.x
   Palmer Nicole O, 2012, Spermatogenesis, V2, P253
   Politch JA, 2007, HUM REPROD, V22, P2928, DOI 10.1093/humrep/dem281
   Raha S, 1998, MOLECULAR BIOMETHODS HANDBOOK, P1, DOI 10.1007/978-1-59259-642-3_1
   Ramirez-Torres M A, 2000, Ginecol Obstet Mex, V68, P224
   Roessner C, 2012, REPROD BIOMED ONLINE, V25, P292, DOI 10.1016/j.rbmo.2012.06.004
   Schoeller EL, 2012, DIABETES, V61, P1869, DOI 10.2337/db11-1527
   Sermondade N, 2013, HUM REPROD UPDATE, V19, P221, DOI 10.1093/humupd/dms050
   Sermondade N, 2012, ARCH INTERN MED, V172, P440, DOI 10.1001/archinternmed.2011.1382
   Shalaby MA, 2004, PHARMACOL RES, V50, P137, DOI 10.1016/j.phrs.2003.10.013
   STAHLER MS, 1987, BIOL REPROD, V36, P999, DOI 10.1095/biolreprod36.4.999
   Taslim S, 2009, ANN ACAD MED SINGAP, V38, P29
   Torkler S, 2011, AGING MALE, V14, P176, DOI 10.3109/13685538.2010.529194
   Truta Z, 2010, ROM BIOTECH LETT, V15, P5764
   WHO, 2010, WORLD MALARIA REPORT 2010, P1
   Wright C, 2014, REPROD BIOMED ONLINE, V28, P684, DOI 10.1016/j.rbmo.2014.02.004
   Yu M, 2013, MOL CELL BIOCHEM, V378, P145, DOI 10.1007/s11010-013-1605-y
   Yu TZ, 2006, P NATL ACAD SCI USA, V103, P2653, DOI 10.1073/pnas.0511154103
   Zhang L, 2011, DIABETES RES CLIN PR, V91, P233, DOI 10.1016/j.diabres.2010.10.016
   Zumárraga M, 2004, GENET MOL BIOL, V27, P17, DOI 10.1590/S1415-47572004000100004
NR 58
TC 9
Z9 9
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD NOV 16
PY 2016
VL 8
AR 76
DI 10.1186/s13098-016-0192-y
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EC2CR
UT WOS:000387917700001
PM 27891185
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Greenberg, S
   Shenhar-Tsarfaty, S
   Rogowski, O
   Shapira, I
   Zeltser, D
   Weinstein, T
   Lahav, D
   Vered, J
   Tovia-Brodie, O
   Arbel, Y
   Berliner, S
   Milwidsky, A
AF Greenberg, Sharon
   Shenhar-Tsarfaty, Shani
   Rogowski, Ori
   Shapira, Itzhak
   Zeltser, David
   Weinstein, Talia
   Lahav, Dror
   Vered, Jaffa
   Tovia-Brodie, Oholi
   Arbel, Yaron
   Berliner, Shlomo
   Milwidsky, Assi
TI Exercise-induced albuminuria is related to metabolic syndrome
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE exercise-induced albuminuria; metabolic syndrome; stress test
ID LOW-GRADE ALBUMINURIA; INDUCED MICROALBUMINURIA; ENDOTHELIAL
   DYSFUNCTION; ASSOCIATION; RISK; INFLAMMATION; POPULATION; COMPONENTS;
   EVENTS; PEOPLE
AB Microalbuminuria (MA) is a known marker for endothelial dysfunction and future cardiovascular events. Exercise-induced albuminuria (EiA) may precede the appearance of MA. Associations between EiA and metabolic syndrome (MS) have not been assessed so far. Our aim was to investigate this association in a large sample of apparently healthy individuals with no baseline albuminuria. This was a cross-sectional study of 2,027 adults with no overt cardiovascular diseases who took part in a health survey program and had no baseline MA. Diagnosis of MS was based on harmonized criteria. All patients underwent an exercise test (Bruce protocol), and urinary albumin was measured before and after the examination. Urinary albumin-to- creatinine ratio (ACR) values before and after exercise were 0.40 (0.21-0.89) and 1.06 (0.43-2.69) mg/g for median (interquartile range) respectively. A total of 394 (20%) subjects had EiA; ACR rose from normal rest values (0.79 mg/g) to 52.28 mg/g after exercise (P < 0.001); this effect was not shown for the rest of the study population. EiA was related to higher prevalence of MS (13.8% vs. 27.1%, P < 0.001), higher metabolic equivalents (P < 0.001), higher baseline blood pressure (P < 0.001), and higher levels of fasting plasma glucose, triglycerides, and body mass index (P < 0.001). Multivariate binary logistic regression model showed that subjects with MS were 98% more likely to have EiA (95% confidence interval: 1.13-3.46, P = 0.016). In conclusion, EiA in the absence of baseline MA is independently related to MS.
C1 [Greenberg, Sharon; Shenhar-Tsarfaty, Shani; Lahav, Dror; Vered, Jaffa; Berliner, Shlomo; Milwidsky, Assi] Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Internal Med E, IL-69978 Tel Aviv, Israel.
   [Rogowski, Ori] Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Internal Med C, IL-69978 Tel Aviv, Israel.
   [Zeltser, David] Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Internal Med D, IL-69978 Tel Aviv, Israel.
   [Shapira, Itzhak; Tovia-Brodie, Oholi; Arbel, Yaron] Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Cardiol, IL-69978 Tel Aviv, Israel.
   [Weinstein, Talia] Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Nephrol, IL-69978 Tel Aviv, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv Sourasky
   Medical Center; Tel Aviv University; Sackler Faculty of Medicine; Tel
   Aviv Sourasky Medical Center; Tel Aviv University; Sackler Faculty of
   Medicine; Tel Aviv Sourasky Medical Center; Tel Aviv University; Sackler
   Faculty of Medicine; Tel Aviv Sourasky Medical Center; Tel Aviv
   University; Sackler Faculty of Medicine; Tel Aviv Sourasky Medical
   Center
RP Greenberg, S (corresponding author), Tel Aviv Sourasky Med Ctr, Dept Internal Med E, 6 Weizman St, IL-64239 Tel Aviv, Israel.
EM sharon.greenberg@gmail.com
RI Brodie, Oholi/AAH-6425-2019; Zeltser, David/LYO-6304-2024
OI Shenhar-Tsarfaty, Shani/0000-0002-8268-1799; Greenberg, Sharon
   A./0000-0001-7346-1746
CR Afonso L, 2010, AM J CARDIOL, V106, P976, DOI 10.1016/j.amjcard.2010.05.028
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Ärnlöv J, 2005, CIRCULATION, V112, P969, DOI 10.1161/CIRCULATIONAHA.105.538132
   Beamer NB, 1999, ARCH NEUROL-CHICAGO, V56, P699, DOI 10.1001/archneur.56.6.699
   BENNETT PH, 1995, AM J KIDNEY DIS, V25, P107
   Chen BD, 2010, CLIN CHIM ACTA, V411, P705, DOI 10.1016/j.cca.2010.01.038
   Choi HS, 2006, NEPHRON CLIN PRACT, V104, pC85, DOI 10.1159/000093995
   CHRISTENSEN CK, 1987, US J CLIN HYPERTENS, V3, P704
   Datta P, 2009, J CLIN LAB ANAL, V23, P314, DOI 10.1002/jcla.20341
   DUMITRESCU C, 1985, REV ROUM MED-MED INT, V23, P19
   Franciosi M, 2007, CLIN J AM SOC NEPHRO, V2, P984, DOI 10.2215/CJN.01190307
   Hao Z, 2007, INTERNAL MED, V46, P341, DOI 10.2169/internalmedicine.46.6056
   Hillege HL, 2002, CIRCULATION, V106, P1777, DOI 10.1161/01.CIR.0000031732.78052.81
   Hillege HL, 2001, J INTERN MED, V249, P519, DOI 10.1046/j.1365-2796.2001.00833.x
   Ibsen H, 2005, HYPERTENSION, V45, P198, DOI 10.1161/01.HYP.0000154082.72286.2a
   Karalliedde J, 2004, AM J HYPERTENS, V17, P986, DOI 10.1016/j.amjhyper.2004.08.010
   Katz DH, 2014, CIRCULATION, V129, P42, DOI 10.1161/CIRCULATIONAHA.113.003429
   Koh KH, 2011, NEPHROLOGY, V16, P704, DOI 10.1111/j.1440-1797.2011.01508.x
   Kornhauser C, 2012, DIABETIC MED, V29, P70, DOI 10.1111/j.1464-5491.2011.03380.x
   Leoncini G, 2012, J HUM HYPERTENS, V26, P149, DOI 10.1038/jhh.2011.2
   Mann JFE, 2008, LANCET, V372, P547, DOI 10.1016/S0140-6736(08)61236-2
   Milwidsky A, 2014, J METABOLIC SYND, V3, P151
   OBRIEN SF, 1995, DIABETES CARE, V18, P1602, DOI 10.2337/diacare.18.12.1602
   Ochodnicky P, 2006, J CARDIOVASC PHARM, V47, pS151, DOI 10.1097/00005344-200606001-00009
   Palaniappan L, 2003, AM J HYPERTENS, V16, P952, DOI 10.1016/S0895-7061(03)01009-4
   ROBINSON RR, 1980, KIDNEY INT, V18, P395, DOI 10.1038/ki.1980.151
   Rocco MV, 2012, AM J KIDNEY DIS, V60, P857, DOI 10.1053/j.ajkd.2012.07.005
   Rogowski O, 2007, HEART, V93, P940, DOI 10.1136/hrt.2006.101949
   Rogowski O, 2008, CLIN ENDOCRINOL, V68, P182, DOI 10.1111/j.1365-2265.2007.03017.x
   ROMANELLI G, 1989, BMJ-BRIT MED J, V298, P284, DOI 10.1136/bmj.298.6669.284
   Sheng CS, 2011, DIABETOL METAB SYNDR, V3, DOI 10.1186/1758-5996-3-6
   Smithies O, 2003, P NATL ACAD SCI USA, V100, P4108, DOI 10.1073/pnas.0730776100
   Stehouwer CDA, 2004, KIDNEY INT, V66, pS42, DOI 10.1111/j.1523-1755.2004.09211.x
   STEHOUWER CDA, 1995, DIABETES, V44, P561, DOI 10.2337/diabetes.44.5.561
   Steinvil A, 2008, AM J CARDIOL, V102, P1034, DOI 10.1016/j.amjcard.2008.05.055
   TORFFVIT O, 1991, SCAND J UROL NEPHROL, V25, P39, DOI 10.3109/00365599109024527
   van der Tol A, 2014, INT UROL NEPHROL, V46, P1601, DOI 10.1007/s11255-014-0718-x
   Weir MR, 2007, CLIN J AM SOC NEPHRO, V2, P581, DOI 10.2215/CJN.03190906
NR 38
TC 16
Z9 16
U1 0
U2 2
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD JUN 1
PY 2016
VL 310
IS 11
BP F1192
EP F1196
DI 10.1152/ajprenal.00481.2015
PG 5
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA DN9YM
UT WOS:000377436600007
PM 27076648
OA Bronze
DA 2025-06-11
ER

PT J
AU Xie, YL
   Wang, MJ
   Zhang, YJ
   Zhang, SJ
   Tan, AH
   Gao, Y
   Liang, ZJ
   Shi, DY
   Huang, Z
   Zhang, HY
   Yang, XB
   Lu, Z
   Wu, CL
   Liao, M
   Sun, Y
   Qin, X
   Hu, YL
   Li, L
   Peng, T
   Li, ZX
   Yang, XL
   Mo, ZN
AF Xie, Yuanliang
   Wang, Mengjie
   Zhang, Youjie
   Zhang, Shijun
   Tan, Aihua
   Gao, Yong
   Liang, Zhengjia
   Shi, Deyi
   Huang, Zhang
   Zhang, Haiying
   Yang, Xiaobo
   Lu, Zheng
   Wu, Chunlei
   Liao, Ming
   Sun, Yu
   Qin, Xue
   Hu, Yanling
   Li, Li
   Peng, Tao
   Li, Zhixian
   Yang, Xiaoli
   Mo, Zengnan
TI Serum Uric Acid and Non-Alcoholic Fatty Liver Disease in Non-Diabetic
   Chinese Men
SO PLOS ONE
LA English
DT Article
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; NATIONAL-HEALTH; RISK-FACTORS;
   ASSOCIATION; PREVALENCE; NUTRITION; GENE; HYPERURICEMIA; POPULATION
AB Increased serum uric acid (SUA) levels may be involved in the development of non-alcoholic fatty liver disease (NAFLD) in men presenting with metabolic syndrome (MetS) and/or insulin resistance. We aimed to determine the independent relationship between SUA and NAFLD in non-diabetic Chinese male population, and to explore the determinants of SUA levels among indexes of adiposity, lipid, and genotypes pertaining to triglycerides metabolism, inflammation, oxidative stress, and SUA concentrations. A total of 1440 men, classified depending on the presence of ultrasonographically detected NAFLD, underwent a complete healthy checkup program. Genotypes were extracted from our previously established genome-wide association study database. After adjusting for age, smoking, drinking, body mass index, homeostasis model assessment of insulin resistance, C-reactive protein, creatinine, alanine aminotransferase (ALT) and components of metabolic syndrome, the odds ratio for NAFLD, comparing the highest with the lowest SUA quartile, was 2.81 (95% confidence interval 1.66-4.76). A stepwise multivariate linear regression analysis (R-2 = 0.238, P<0.001) retained age, waist circumference, serum creatinine, triglycerides, the Q141K variant in ABCG2 (rs2231142) and NAFLD as significant predictors of SUA levels (all P<0.001). Besides, ALT and Met196Arg variant in TNFRSF1B (rs1061622) additionally associated with SUA among individuls with NAFLD. Our data suggest that in Chinese men, elevated SUA is significantly associated with NAFLD, independent of insulin resistance and other metabolic disorders, such as central obesity or hypertriglyceridemia. Meanwhile, among subjects with NAFLD, index of liver damage, such as elevated ALT combined with genetic susceptibility to inflammation associated with increased SUA levels.
C1 [Xie, Yuanliang; Zhang, Youjie; Lu, Zheng; Wu, Chunlei; Liao, Ming; Mo, Zengnan] Guangxi Med Univ, Affiliated Hosp 1, Inst Urol & Nephrol, Nanning, Guangxi Zhuang, Peoples R China.
   [Wang, Mengjie; Zhang, Shijun; Tan, Aihua; Gao, Yong; Mo, Zengnan] Guangxi Med Univ, Ctr Genom & Personalized Med, Nanning, Guangxi Zhuang, Peoples R China.
   [Liang, Zhengjia; Shi, Deyi; Huang, Zhang] Fangchenggang First Peoples Hosp, Med Examinat Ctr, Fangchenggang, Guangxi Zhuang, Peoples R China.
   [Zhang, Haiying; Yang, Xiaobo] Guangxi Med Univ, Sch Publ Hlth, Dept Occupat Hlth & Environm Hlth, Nanning, Guangxi Zhuang, Peoples R China.
   [Sun, Yu; Li, Zhixian] Guangxi Med Univ, Affiliated Hosp 1, Dept Ultrasound, Nanning, Guangxi Zhuang, Peoples R China.
   [Qin, Xue] Guangxi Med Univ, Affiliated Hosp 1, Dept Clin Lab, Nanning, Guangxi Zhuang, Peoples R China.
   [Hu, Yanling; Li, Li; Yang, Xiaoli] Guangxi Med Univ, Med Sci Res Ctr, Nanning, Guangxi Zhuang, Peoples R China.
   [Peng, Tao] Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Nanning, Guangxi Zhuang, Peoples R China.
C3 Guangxi Medical University; Guangxi Medical University; Guangxi Medical
   University; Guangxi Medical University; Guangxi Medical University;
   Guangxi Medical University; Guangxi Medical University
RP Yang, XL (corresponding author), Guangxi Med Univ, Med Sci Res Ctr, Nanning, Guangxi Zhuang, Peoples R China.
EM cncsyxl@gmail.com
RI Wu, Chunlei/ABF-4720-2020; Yang, Xiaobo/G-3854-2016; Peng,
   Tao/LXB-5171-2024; Wang, xiaoxiao/GQQ-2846-2022; qin, xue/KQV-3701-2024;
   Hu, Yanling/LTZ-0129-2024; Liao, Ming/LEL-9197-2024; Xie,
   Yuanliang/KIC-3241-2024; Zhang, Youjie/F-7346-2016
OI mo, zengnan/0000-0002-3047-3138; Zhang, Youjie/0000-0002-6035-8536
FU National Natural Science Foundation of China [81060029, 81060234,
   30945204, 81060214]; Key Program and University Talents Highland
   Innovation Team of Guangxi [2012012D003, GJR201147-09]; Chairman Science
   and Technology Fund and Tackle Program of Guangxi [1116-03,
   GKG1298003-07-01]; Guangxi Provincial Department of Finance and
   Education [2009GJCJ150]; Guangxi Natural Science Foundation
   [2011GXNSFA018175, 2010GXNSFA013133]
FX The work described in this article was supported by grants from the
   National Natural Science Foundation of China (81060029, 81060234,
   30945204, 81060214), Key Program and University Talents Highland
   Innovation Team of Guangxi (2012012D003, GJR201147-09), Chairman Science
   and Technology Fund and Tackle Program of Guangxi (1116-03,
   GKG1298003-07-01), Guangxi Provincial Department of Finance and
   Education (2009GJCJ150), and Guangxi Natural Science Foundation
   (2011GXNSFA018175, and 2010GXNSFA013133). The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
CR Afzali A, 2010, HEPATOLOGY, V52, P578, DOI 10.1002/hep.23717
   Al-Serri A, 2012, J HEPATOL, V56, P448, DOI 10.1016/j.jhep.2011.05.029
   Alvarez-Lario B, 2010, RHEUMATOLOGY, V49, P2010, DOI 10.1093/rheumatology/keq204
   Angulo P, 2002, NEW ENGL J MED, V346, P1221, DOI 10.1038/nrdp.2015.80
   Beavers KM, 2009, J NUTR HEALTH AGING, V13, P177, DOI 10.1007/s12603-009-0054-5
   Bedogni G, 2005, HEPATOLOGY, V42, P44, DOI 10.1002/hep.20734
   Choi HK, 2005, ARTHRITIS RHEUM-US, V52, P283, DOI 10.1002/art.20761
   Choi SS, 2008, CURR OPIN LIPIDOL, V19, P295, DOI 10.1097/MOL.0b013e3282ff5e55
   de Oliveira EP, 2012, DIABETOL METAB SYNDR, V4, DOI 10.1186/1758-5996-4-12
   Dehghan A, 2008, LANCET, V372, P1953, DOI 10.1016/S0140-6736(08)61343-4
   FACCHINI F, 1991, JAMA-J AM MED ASSOC, V266, P3008, DOI 10.1001/jama.266.21.3008
   Fan JG, 2005, J HEPATOL, V43, P508, DOI 10.1016/j.jhep.2005.02.042
   Fang J, 2000, JAMA-J AM MED ASSOC, V283, P2404, DOI 10.1001/jama.283.18.2404
   Feig DI, 2008, NEW ENGL J MED, V359, P1811, DOI 10.1056/NEJMra0800885
   Gaffo AL, 2009, ARTHRITIS RES THER, V11, DOI 10.1186/ar2761
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Gu DF, 2005, LANCET, V365, P1398, DOI 10.1016/S0140-6736(05)66375-1
   Hoque R, 2013, J HEPATOL, V58, P1047, DOI 10.1016/j.jhep.2012.12.017
   Hou XH, 2011, J GASTROEN HEPATOL, V26, P722, DOI 10.1111/j.1440-1746.2010.06509.x
   Kolz M, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000504
   Kono H, 2010, J CLIN INVEST, V120, P1939, DOI 10.1172/JCI40124
   Kountouras J, 1996, HEPATOLOGY, V23, P229
   Li YM, 2009, J HEPATOL, V50, P1029, DOI 10.1016/j.jhep.2008.11.021
   Lin YC, 2009, PEDIATRICS, V124, pE1221, DOI 10.1542/peds.2008-3087
   Marchesini G, 2003, HEPATOLOGY, V37, P917, DOI 10.1053/jhep.2003.50161
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Meziri M, 2005, ULTRASONICS, V43, P305, DOI 10.1016/j.ultras.2004.09.002
   Onat A, 2006, AM J HYPERTENS, V19, P1055, DOI 10.1016/j.amjhyper.2006.02.014
   Peng XE, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0050256
   Petta S, 2011, ALIMENT PHARM THER, V34, P757, DOI 10.1111/j.1365-2036.2011.04788.x
   Powell EE, 2010, DIGEST DIS, V28, P186, DOI 10.1159/000282084
   Ryu S, 2011, METABOLISM, V60, P860, DOI 10.1016/j.metabol.2010.08.005
   Saadeh S, 2002, GASTROENTEROLOGY, V123, P745, DOI 10.1053/gast.2002.35354
   Sautin YY, 2007, AM J PHYSIOL-CELL PH, V293, pC584, DOI 10.1152/ajpcell.00600.2006
   Shi Y, 2010, J CLIN INVEST, V120, P1809, DOI 10.1172/JCI43132
   Sirota JC, 2013, METABOLISM, V62, P392, DOI 10.1016/j.metabol.2012.08.013
   Tan AH, 2012, HUM MOL GENET, V21, P1658, DOI 10.1093/hmg/ddr587
   Tian GX, 2012, OBES REV, V13, P381, DOI 10.1111/j.1467-789X.2011.00978.x
   Tokushige K, 2007, J HEPATOL, V46, P1104, DOI 10.1016/j.jhep.2007.01.028
   Xu CF, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011578
   Yoo TW, 2005, CIRC J, V69, P928, DOI 10.1253/circj.69.928
NR 41
TC 37
Z9 44
U1 0
U2 20
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 23
PY 2013
VL 8
IS 7
AR e67152
DI 10.1371/journal.pone.0067152
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 228SX
UT WOS:000325211000009
PM 23935829
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Campia, U
   Tesauro, M
   Cardillo, C
AF Campia, Umberto
   Tesauro, Manfredi
   Cardillo, Carmine
TI Human obesity and endothelium-dependent responsiveness
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Review
DE Obesity; endothelium; metabolic syndrome; vasodilation; oxidative stress
ID NECROSIS-FACTOR-ALPHA; PERIVASCULAR ADIPOSE-TISSUE; ACTIVATED
   PROTEIN-KINASE; NITRIC-OXIDE SYNTHASE; BODY-FAT DISTRIBUTION;
   CARDIOVASCULAR RISK-FACTORS; TYPE-2 DIABETES-MELLITUS; PERIPHERAL-BLOOD
   FLOW; INSULIN-RESISTANCE; METABOLIC SYNDROME
AB Obesity is an ongoing worldwide epidemic. Besides being a medical condition in itself, obesity dramatically increases the risk of development of metabolic and cardiovascular disease. This risk appears to stem from multiple abnormalities in adipose tissue function leading to a chronic inflammatory state and to dysregulation of the endocrine and paracrine actions of adipocyte-derived factors. These, in turn, disrupt vascular homeostasis by causing an imbalance between the NO pathway and the endothelin 1 system, with impaired insulin-stimulated endothelium-dependent vasodilation. Importantly, emerging evidence suggests that the vascular dysfunction of obesity is not just limited to the endothelium, but also involves the other layers of the vessel wall. In particular, obesity-related changes in medial smooth muscle cells seem to disrupt the physiological facilitatory action of insulin on the responsiveness to vasodilator stimuli, whereas the adventitia and perivascular fat appear to be a source of pro-inflammatory and vasoactive factors that may contribute to endothelial and smooth muscle cell dysfunction, and to the pathogenesis of vascular disease. While obesity-induced vascular dysfunction appears to be reversible, at least in part, with weight control strategies, these have not proved sufficient to prevent the metabolic and cardiovascular complication of obesity on a large scale. While a number of currently available drugs have shown potentially beneficial vascular effects in patients with obesity and the metabolic syndrome, elucidation of the pathophysiological mechanisms underlying vascular damage in obese patients is necessary to identify additional pharmacologic targets to prevent the cardiovascular complications of obesity, and their human and economic costs.
C1 [Cardillo, Carmine] Univ Cattolica Sacro Cuore, Ist Patol Speciale Med & Semeiot, Dept Internal Med, I-00168 Rome, Italy.
   [Campia, Umberto] Northwestern Univ, Dept Cardiol, Feinberg Sch Med, Chicago, IL 60611 USA.
   [Tesauro, Manfredi] Univ Roma Tor Vergata, Dept Internal Med, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Northwestern University; Feinberg School of Medicine; University of Rome
   Tor Vergata
RP Cardillo, C (corresponding author), Univ Cattolica Sacro Cuore, Ist Patol Speciale Med & Semeiot, Dept Internal Med, Largo Gemelli 8, I-00168 Rome, Italy.
EM carmine.cardillo@rm.unicatt.it
OI Cardillo, Carmine/0000-0001-5182-3005
FU National Institutes of Health [K12-HL083790]; Fondazione Roma;
   Universita Cattolica del Sacro Cuore
FX This work was partially supported by a National Institutes of Health
   grant (K12-HL083790) to UC, by Fondazione Roma grant to MT, and by Fondi
   d'Ateneo grants from the Universita Cattolica del Sacro Cuore to CC.
CR Ahima RS, 2000, ANNU REV PHYSIOL, V62, P413, DOI 10.1146/annurev.physiol.62.1.413
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Arslanian S, 2002, HORM RES, V57, P19, DOI 10.1159/000053308
   Ayyad C, 2000, Obes Rev, V1, P113, DOI 10.1046/j.1467-789x.2000.00019.x
   BARON AD, 1995, J CLIN INVEST, V96, P786, DOI 10.1172/JCI118124
   Baron AD, 1997, ANNU REV NUTR, V17, P487, DOI 10.1146/annurev.nutr.17.1.487
   Baur JA, 2006, NAT REV DRUG DISCOV, V5, P493, DOI 10.1038/nrd2060
   Bendall JK, 2005, CIRC RES, V97, P864, DOI 10.1161/01.RES.0000187447.03525.72
   Berenson GS, 1998, NEW ENGL J MED, V338, P1650, DOI 10.1056/NEJM199806043382302
   BEVILACQUA S, 1987, METABOLISM, V36, P502, DOI 10.1016/0026-0495(87)90051-5
   Bigornia SJ, 2010, OBESITY, V18, P754, DOI 10.1038/oby.2009.482
   BJORNTORP P, 1990, ARTERIOSCLEROSIS, V10, P493, DOI 10.1161/01.ATV.10.4.493
   BJORNTORP P, 1991, DIABETES CARE, V14, P1132, DOI 10.2337/diacare.14.12.1132
   Bornstein SR, 2008, EXP CLIN ENDOCR DIAB, V116, pS30, DOI 10.1055/s-2008-1081485
   BOUCHARD C, 1993, ENDOCR REV, V14, P72, DOI 10.1210/er.14.1.72
   Bradley EA, 2010, ARTERIOSCL THROM VAS, V30, P1137, DOI 10.1161/ATVBAHA.110.204404
   Brook RD, 2004, AM J CARDIOL, V93, P1012, DOI 10.1016/j.amjcard.2004.01.009
   Brooks CL, 2009, NAT REV CANCER, V9, P123, DOI 10.1038/nrc2562
   Cai H, 2000, CIRC RES, V87, P840, DOI 10.1161/01.RES.87.10.840
   Campia U, 2006, CIRCULATION, V113, P867, DOI 10.1161/CIRCULATIONAHA.105.549618
   Caprio S, 2002, J PEDIATR ENDOCR MET, V15, P487
   Cardillo C, 2004, HYPERTENSION, V43, P36, DOI 10.1161/01.HYP.0000103868.45064.81
   Cardillo C, 1999, CIRCULATION, V100, P820, DOI 10.1161/01.CIR.100.8.820
   Cardillo C, 1998, HYPERTENSION, V32, P740, DOI 10.1161/01.HYP.32.4.740
   Carey VJ, 1997, AM J EPIDEMIOL, V145, P614, DOI 10.1093/oxfordjournals.aje.a009158
   Cassano Patricia A., 1990, Annals of Epidemiology, V1, P33
   CHAN JM, 1994, DIABETES CARE, V17, P961, DOI 10.2337/diacare.17.9.961
   Chen H, 2003, J BIOL CHEM, V278, P45021, DOI 10.1074/jbc.M307878200
   Chiarugi P, 2010, EXPERT OPIN THER TAR, V14, P193, DOI 10.1517/14728220903530712
   Clark MG, 2003, AM J PHYSIOL-ENDOC M, V284, pE241, DOI 10.1152/ajpendo.00408.2002
   Cusi K, 2000, J CLIN INVEST, V105, P311, DOI 10.1172/JCI7535
   Dandona P, 2007, J HUM HYPERTENS, V21, P20, DOI 10.1038/sj.jhh.1002101
   Davis BJ, 2006, DIABETES, V55, P496, DOI 10.2337/diabetes.55.02.06.db05-1064
   De Acular LGK, 2006, DIABETES CARE, V29, P1083, DOI 10.2337/dc05-2146
   de Jongh RT, 2004, DIABETES, V53, P2873, DOI 10.2337/diabetes.53.11.2873
   De Keulenaer GW, 1998, BIOCHEM J, V329, P653
   deHaan CHA, 1997, CARDIOVASC RES, V34, P192, DOI 10.1016/S0008-6363(97)00035-7
   Djaberi R, 2008, AM J CARDIOL, V102, P1602, DOI 10.1016/j.amjcard.2008.08.010
   Eid HMA, 2007, ATHEROSCLEROSIS, V194, pE1, DOI 10.1016/j.atherosclerosis.2006.11.008
   Fehmann HC, 2002, HORM METAB RES, V34, P671, DOI 10.1055/s-2002-38241
   FERRANNINI E, 1983, J CLIN INVEST, V72, P1737, DOI 10.1172/JCI111133
   Ferri C, 1999, HYPERTENSION, V34, P568, DOI 10.1161/01.HYP.34.4.568
   Galic S, 2010, MOL CELL ENDOCRINOL, V316, P129, DOI 10.1016/j.mce.2009.08.018
   Gao YJ, 2007, BRIT J PHARMACOL, V151, P323, DOI 10.1038/sj.bjp.0707228
   Gao YJ, 2005, J THORAC CARDIOV SUR, V130, P1130, DOI 10.1016/j.jtcvs.2005.05.028
   Goran MI, 1998, CORONARY ARTERY DIS, V9, P483, DOI 10.1097/00019501-199809080-00003
   Greenstein AS, 2009, CIRCULATION, V119, P1661, DOI 10.1161/CIRCULATIONAHA.108.821181
   Gronbæk M, 2002, ANN NY ACAD SCI, V957, P16, DOI 10.1111/j.1749-6632.2002.tb02902.x
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Haslam DW, 2005, LANCET, V366, P1197, DOI 10.1016/S0140-6736(05)67483-1
   Home PD, 2009, LANCET, V373, P2125, DOI 10.1016/S0140-6736(09)60953-3
   Hotamisligil GS, 1996, SCIENCE, V271, P665, DOI 10.1126/science.271.5249.665
   Hundal RS, 2003, DRUGS, V63, P1879, DOI 10.2165/00003495-200363180-00001
   Iantorno M, 2007, AM J PHYSIOL-ENDOC M, V292, pE756, DOI 10.1152/ajpendo.00570.2006
   Jia SJ, 2006, VASC PHARMACOL, V44, P143, DOI 10.1016/j.vph.2005.09.005
   Kahn BB, 2000, J CLIN INVEST, V106, P473, DOI 10.1172/JCI10842
   Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213
   KISSEBAH AH, 1989, MED CLIN N AM, V73, P111, DOI 10.1016/S0025-7125(16)30695-2
   Kojima M, 1999, NATURE, V402, P656, DOI 10.1038/45230
   Korda M, 2008, AM J PHYSIOL-HEART C, V295, pH1514, DOI 10.1152/ajpheart.00479.2008
   LAAKSO M, 1990, J CLIN INVEST, V85, P1844, DOI 10.1172/JCI114644
   Lara-Castro C, 2006, DIABETES, V55, P249, DOI 10.2337/diabetes.55.01.06.db05-1105
   Lazar MA, 2007, HORM METAB RES, V39, P710, DOI 10.1055/s-2007-985897
   Lee DE, 2009, AM J PHYSIOL-ENDOC M, V296, pE1210, DOI 10.1152/ajpendo.00015.2009
   LEVIN ER, 1995, NEW ENGL J MED, V333, P356, DOI 10.1056/NEJM199508103330607
   LIND L, 1993, AM HEART J, V125, P1494, DOI 10.1016/0002-8703(93)90446-G
   Martin SS, 2008, J AM COLL CARDIOL, V52, P1201, DOI 10.1016/j.jacc.2008.05.060
   Mather KJ, 2004, DIABETES, V53, P2060, DOI 10.2337/diabetes.53.8.2060
   Mather KJ, 2002, DIABETES, V51, P3517, DOI 10.2337/diabetes.51.12.3517
   Matsubara M, 2002, EUR J ENDOCRINOL, V147, P173, DOI 10.1530/eje.0.1470173
   Mattagajasingh I, 2007, P NATL ACAD SCI USA, V104, P14855, DOI 10.1073/pnas.0704329104
   Mavri A, 2011, HEART VESSELS, V26, P31, DOI 10.1007/s00380-010-0016-1
   MOHAMED F, 1995, ARTERIOSCL THROM VAS, V15, P52, DOI 10.1161/01.ATV.15.1.52
   Mokdad AH, 2003, JAMA-J AM MED ASSOC, V289, P76, DOI 10.1001/jama.289.1.76
   Morrow VA, 2003, J BIOL CHEM, V278, P31629, DOI 10.1074/jbc.M212831200
   Motoshima H, 2004, BIOCHEM BIOPH RES CO, V315, P264, DOI 10.1016/j.bbrc.2004.01.049
   Muniyappa R., 2008, Endocrinol Metab Clin North Am, V37, pix
   Muniyappa R, 2008, ENDOCRIN METAB CLIN, V37, P685, DOI 10.1016/j.ecl.2008.06.001
   Nissen SE, 2007, NEW ENGL J MED, V356, P2457, DOI 10.1056/NEJMoa072761
   Nissen SE, 2010, ARCH INTERN MED, V170, P1191, DOI 10.1001/archinternmed.2010.207
   Otani H, 2011, ANTIOXID REDOX SIGN, V15, P1911, DOI 10.1089/ars.2010.3739
   Pasarica M, 2009, DIABETES, V58, P718, DOI 10.2337/db08-1098
   Perticone F, 2001, DIABETES, V50, P159, DOI 10.2337/diabetes.50.1.159
   Piatti P, 1996, DIABETES, V45, P316, DOI 10.2337/diabetes.45.3.316
   Pierce GL, 2008, HYPERTENSION, V52, P72, DOI 10.1161/HYPERTENSIONAHA.108.111427
   Pistrosch F, 2004, DIABETES CARE, V27, P484, DOI 10.2337/diacare.27.2.484
   Pittas AG, 2004, J CLIN ENDOCR METAB, V89, P447, DOI 10.1210/jc.2003-031005
   Rask-Madsen C, 2003, CIRCULATION, V108, P1815, DOI 10.1161/01.CIR.0000091406.72832.11
   REAVEN GM, 1987, LANCET, V2, P435
   REBUFFESCRIVE M, 1989, METABOLISM, V38, P453, DOI 10.1016/0026-0495(89)90198-4
   REBUFFESCRIVE M, 1990, METABOLISM, V39, P1021, DOI 10.1016/0026-0495(90)90160-E
   Ren J, 2004, J ENDOCRINOL, V181, P1, DOI 10.1677/joe.0.1810001
   Saltiel AR, 2001, NATURE, V414, P799, DOI 10.1038/414799a
   Schinzari F, 2010, AM J PHYSIOL-ENDOC M, V299, pE947, DOI 10.1152/ajpendo.00426.2010
   Schoonjans K, 2000, LANCET, V355, P1008, DOI 10.1016/S0140-6736(00)90002-3
   Sekuri C, 2003, INT J CLIN PHARM RES, V23, P111
   Siekmeier R, 2008, J CARDIOVASC PHARM T, V13, P279, DOI 10.1177/1074248408326488
   SNIDERMAN AD, 1995, INT J OBESITY, V19, pS27
   Söderberg S, 1999, J INTERN MED, V246, P409, DOI 10.1046/j.1365-2796.1999.00571.x
   Sola S, 2005, CIRCULATION, V111, P343, DOI 10.1161/01.CIR.0000153272.48711.B9
   SOLTIS EE, 1991, CLIN EXP HYPERTENS A, V13, P277, DOI 10.3109/10641969109042063
   Steinberg HO, 1997, J CLIN INVEST, V100, P1230, DOI 10.1172/JCI119636
   Steinberg HO, 1996, J CLIN INVEST, V97, P2601, DOI 10.1172/JCI118709
   Sweeney G, 2010, NAT REV CARDIOL, V7, P22, DOI 10.1038/nrcardio.2009.224
   Tack CJJ, 1996, HYPERTENSION, V28, P426, DOI 10.1161/01.HYP.28.3.426
   Tesauro M, 2005, CIRCULATION, V112, P2986, DOI 10.1161/CIRCULATIONAHA.105.553883
   Tesauro M, 2008, DIABETES CARE, V31, P1439, DOI 10.2337/dc08-0219
   Tesauro M, 2010, CURR DIABETES REV, V6, P228, DOI 10.2174/157339910791658871
   Tesauro M, 2009, HYPERTENSION, V54, P995, DOI 10.1161/HYPERTENSIONAHA.109.137729
   Tschöp M, 2001, DIABETES, V50, P707, DOI 10.2337/diabetes.50.4.707
   Turner RC, 1998, LANCET, V352, P854, DOI 10.1016/s0140-6736(98)07037-8
   VAGUE J, 1956, AM J CLIN NUTR, V4, P20, DOI 10.1093/ajcn/4.1.20
   van der Lely AJ, 2004, ENDOCR REV, V25, P426, DOI 10.1210/er.2002-0029
   Van Guilder GP, 2006, J CARDIOVASC PHARM, V47, P310, DOI 10.1097/01.fjc.0000205097.29946.d3
   Vicent D, 2003, J CLIN INVEST, V111, P1373, DOI 10.1172/JCI200315211
   Vitale C, 2005, J INTERN MED, V258, P250, DOI 10.1111/j.1365-2796.2005.01531.x
   Wang CP, 2009, CLIN ENDOCRINOL, V70, P876, DOI 10.1111/j.1365-2265.2008.03411.x
   Wang SX, 2009, DIABETES, V58, P1893, DOI 10.2337/db09-0267
   Watanabe S, 2005, ARTERIOSCL THROM VAS, V25, P2376, DOI 10.1161/01.ATV.0000187465.55507.85
   Wellen KE, 2003, J CLIN INVEST, V112, P1785, DOI 10.1172/JCI20514
   Weyer C, 2001, J CLIN ENDOCR METAB, V86, P1930, DOI 10.1210/jc.86.5.1930
   Wong RH, 2011, NUTR METAB IN PRESS
   Woo KS, 2004, INT J OBESITY, V28, P852, DOI 10.1038/sj.ijo.0802539
   Woo KS, 2004, CIRCULATION, V109, P1981, DOI 10.1161/01.CIR.0000126599.47470.BE
   Yamauchi T, 2002, NAT MED, V8, P1288, DOI 10.1038/nm788
   Yki-Jarvinen H, 2004, NEW ENGL J MED, V351, P1106, DOI 10.1056/NEJMra041001
   Yki-Järvinen H, 1998, DIABETOLOGIA, V41, P369, DOI 10.1007/s001250050919
   YOSHIZUMI M, 1993, CIRC RES, V73, P205, DOI 10.1161/01.RES.73.1.205
   Yudkin JS, 2005, LANCET, V365, P1817, DOI 10.1016/S0140-6736(05)66585-3
   Zeng GY, 2000, CIRCULATION, V101, P1539, DOI 10.1161/01.CIR.101.13.1539
   Zhang L, 2004, DIABETES, V53, P447, DOI 10.2337/diabetes.53.2.447
   Ziccardi P, 2002, CIRCULATION, V105, P804, DOI 10.1161/hc0702.104279
NR 132
TC 91
Z9 105
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD FEB
PY 2012
VL 165
IS 3
SI SI
BP 561
EP 573
DI 10.1111/j.1476-5381.2011.01661.x
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 874JS
UT WOS:000298953100003
PM 21895631
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Kamaura, M
   Nishijima, K
   Takahashi, M
   Ando, T
   Mizushima, S
   Tochikubo, O
AF Kamaura, Mitsumasa
   Nishijima, Kiyoko
   Takahashi, Mitsuo
   Ando, Toshihiko
   Mizushima, Shunsaku
   Tochikubo, Osamu
TI Lifestyle Modification in Metabolic Syndrome and Associated Changes in
   Plasma Amino Acid Profiles
SO CIRCULATION JOURNAL
LA English
DT Article
DE Amino acid; Lifestyle modification; Metabolic syndrome
ID OXIDATIVE STRESS; EXERCISE INTERVENTION; NITRIC-OXIDE; INFLAMMATION;
   DISEASE; OBESITY; RISK; DIAGNOSIS; PATHWAY; GLUCOSE
AB Background: Although lifestyle modification is the key treatment of metabolic syndrome (MetS), clinical data on the dynamical relationship between metabolic state and MetS has been limited. This study investigated the mutual correlations between demographic and biochemical variables, and the metabolic state based on the plasma amino acid (AA) concentrations, during a lifestyle modification for MetS.
   Methods and Results: Japanese subjects, consisting of 54 patients with MetS [MetS(+)] and 35 persons without MetS [MetS(-)] were included in the study. Before a lifestyle modification program, the levels of glutamate metabolism-related AA (Glu-mAA), aromatic AA metabolism-related AA (Aromatic-mAA) and alanine metabolism-related AA (Ala-mAA) were significantly higher, while those of glycine-serine-threonine metabolism-related AA (Gly-Ser-Thr-mAA) were significantly lower compared to those in MetS(-). After a lifestyle modification, significant reductions (P<0.05) in the BMI (-1.4 kg/m(2)), mean blood pressure (-7.9 mmHg), hemoglobin A(1c) (-0.4%), and triglycerides (-30.6 mg/dl) were observed, and significant differences in the plasma AA levels between MetS(+) and MetS(-) were resolved. In addition, the diagnostic items of MetS were positively correlated with the levels of Glu-mAA, Ala-mAA, branched chain AA (BCAA)-mAA, Aromatic-mAA, and negatively correlated with the levels of Gly-Ser-Thr-mAA.
   Conclusions: As MetS subsided, the abnormality of mean plasma AA levels of the MetS(+) group returned to similar values as those in the MetS() group, suggesting a novel viewpoint regarding the metabolic mechanism of lifestyle modification. (Circ J 2010; 74: 2434-2440)
C1 [Kamaura, Mitsumasa] Kanagawa Hlth Serv Assoc, Dept Occupat Hlth, Kanazawa Ku, Yokohama, Kanagawa 2368530, Japan.
   [Takahashi, Mitsuo; Ando, Toshihiko] Ajinomoto Co Inc, Inst Life Sci, Kawasaki, Kanagawa, Japan.
   [Nishijima, Kiyoko; Mizushima, Shunsaku; Tochikubo, Osamu] Yokohama City Univ, Sch Med, Dept Publ Hlth, Yokohama, Kanagawa 232, Japan.
C3 Ajinomoto Co Inc; Yokohama City University
RP Kamaura, M (corresponding author), Kanagawa Hlth Serv Assoc, Dept Occupat Hlth, Kanazawa Ku, 13-7 Torihama Machi, Yokohama, Kanagawa 2368530, Japan.
EM m-kamaura@yobouigaku-kanagawa.or.jp
CR [Anonymous], 2005, Nihon Naika Gakkai Zasshi, V94, P794
   Avruch J, 2009, AM J PHYSIOL-ENDOC M, V296, pE592, DOI 10.1152/ajpendo.90645.2008
   Chevalier S, 2006, DIABETES, V55, P675, DOI 10.2337/diabetes.55.03.06.db05-1117
   Cynober LA., 2004, METABOLIC THERAPEUTI, V2nd
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   FELIG P, 1970, DIABETES, V19, P727, DOI 10.2337/diab.19.10.727
   FELIG P, 1969, NEW ENGL J MED, V281, P811, DOI 10.1056/NEJM196910092811503
   FISCHER JE, 1975, SURGERY, V78, P276
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Graham IM, 1997, JAMA-J AM MED ASSOC, V277, P1775, DOI 10.1001/jama.277.22.1775
   Grundy SM, 2004, ARTERIOSCL THROM VAS, V24, pE13, DOI 10.1161/01.ATV.0000111245.75752.C6
   HISHIKAWA K, 1993, J HYPERTENS, V11, P639, DOI 10.1097/00004872-199306000-00008
   Hotta K, 2000, ARTERIOSCL THROM VAS, V20, P1595, DOI 10.1161/01.ATV.20.6.1595
   IGNARRO LJ, 1981, J PHARMACOL EXP THER, V218, P739
   Jeong H, 2000, NATURE, V407, P651, DOI 10.1038/35036627
   Kanehisa M, 2000, NUCLEIC ACIDS RES, V28, P27, DOI 10.1093/nar/28.1.27
   Keys JR, 2004, RECENT PROG HORM RES, V59, P13, DOI 10.1210/rp.59.1.13
   Kimura T, 2009, CURR OPIN CLIN NUTR, V12, P49, DOI 10.1097/MCO.0b013e3283169242
   Kobayashi H, 2001, JPN CIRC J, V65, P193, DOI 10.1253/jcj.65.193
   Kohro T, 2008, INT HEART J, V49, P193, DOI 10.1536/ihj.49.193
   Kokubo Y, 2009, CIRC J, V73, P1381, DOI 10.1253/circj.CJ-09-0336
   MARK AL, 1990, J HYPERTENS, V8, pS67
   MEIJER AJ, 1990, PHYSIOL REV, V70, P701, DOI 10.1152/physrev.1990.70.3.701
   Morris SM, 2002, ANNU REV NUTR, V22, P87, DOI 10.1146/annurev.nutr.22.110801.140547
   NATHAN C, 1994, J BIOL CHEM, V269, P13725
   Noguchi Y, 2006, AM J CLIN NUTR, V83, p513S
   Rennie MJ, 2006, J NUTR, V136, p264S, DOI 10.1093/jn/136.1.264S
   Roberts CK, 2006, DIABETES RES CLIN PR, V73, P249, DOI 10.1016/j.diabres.2006.02.013
   Roberts CK, 2006, J APPL PHYSIOL, V100, P1657, DOI 10.1152/japplphysiol.01292.2005
   Saltiel AR, 2001, NATURE, V414, P799, DOI 10.1038/414799a
   Shimabukuro M, 2009, CIRC J, V73, P27, DOI 10.1253/circj.CJ-08-1012
   Shimbo K, 2010, BIOMED CHROMATOGR, V24, P683, DOI 10.1002/bmc.1346
   TAKAHASHI M, 2006, NINGEN DOCK OFFICIAL, V21, P417
   Wagner A, 2001, P ROY SOC B-BIOL SCI, V268, P1803, DOI 10.1098/rspb.2001.1711
   Watanabe M, 2008, AM J CLIN NUTR, V87, P1860, DOI 10.1093/ajcn/87.6.1860
   Zhang QW, 2006, HEPATOL RES, V34, P170, DOI 10.1016/j.hepres.2005.12.006
NR 36
TC 29
Z9 32
U1 0
U2 4
PU JAPANESE CIRCULATION SOC
PI TOYKO
PA 18TH FLOOR IMPERIAL HOTEL TOWER, 1-1-1 UCHISAIWAI-CHO CHIYODA-KU, TOYKO,
   100-0011, JAPAN
SN 1346-9843
EI 1347-4820
J9 CIRC J
JI Circ. J.
PD NOV
PY 2010
VL 74
IS 11
BP 2434
EP 2440
DI 10.1253/circj.CJ-10-0150
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 672YG
UT WOS:000283623200032
PM 20834187
OA Bronze
DA 2025-06-11
ER

PT J
AU Giralt, M
   Díaz-Delfín, J
   Gallego-Escuredo, JM
   Villarroya, J
   Domingo, P
   Villarroya, F
AF Giralt, Marta
   Diaz-Delfin, Julieta
   Gallego-Escuredo, Jose M.
   Villarroya, Joan
   Domingo, Pere
   Villarroya, Francesc
TI Lipotoxicity on the Basis of Metabolic Syndrome and Lipodystrophy in
   HIV-1-Infected Patients Under Antiretroviral Treatment
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Lipotoxicity; lipodystrophy; HIV; fatty acids; adipose tissue
ID CONGENITAL GENERALIZED LIPODYSTROPHY; FAMILIAL PARTIAL LIPODYSTROPHY;
   ENDOPLASMIC-RETICULUM STRESS; HIV-ASSOCIATED LIPODYSTROPHY;
   ADIPOSE-TISSUE; INSULIN-RESISTANCE; PPAR-GAMMA; GROWTH-HORMONE; PROTEASE
   INHIBITOR; MOUSE MODELS
AB The development of efficacious antiretroviral drugs that minimize adverse effects is a current challenge in HIV-1 therapy. Metabolic alterations reminiscent of the metabolic syndrome and overt lipodystrophy appear often in HIV-1-infected patients undergoing antiretroviral treatment. The etiopathogenesis of these alterations is complex, but lipotoxicity has recently emerged as a key concept for explaining the metabolic syndrome in HIV-1-infected patients, similarly to what has been observed in diseases such as obesity and genetic lipodystrophies. Antiretroviral drugs from distinct drug families may directly elicit such lipotoxic phenomena, via increased lipolysis, enhanced adipocyte apoptosis and impaired adipogenesis, which collectively lead to a reduced capacity of subcutaneous adipose tissue to enlarge to meet fat storage requirements. Thus, fatty acids that cannot be properly stored as triglycerides in subcutaneous adipose tissue are expected to accumulate in visceral fat as well as in organs and tissues, such as the pancreas, muscle and liver, leading to the pattern of metabolic alterations associated with abnormal ectopic fat accumulation, mainly insulin resistance. Inflammatory responses, evoked by the combined effects of antiretroviral drugs and the underlying HIV-1 infection, also contribute to lipotoxicity, reflecting the action of pro-inflammatory cytokines that enhance lipolytic activity in adipose tissue and impair adipogenesis. Minimizing the lipotoxic action of antiretroviral drugs is ultimately essential in reducing metabolic alterations in treated patients. Moreover, pharmacological strategies that reduce lipotoxicity and promote adipose tissue expandability can be expected to ameliorate the overall metabolic abnormalities in HIV-1-infected, antiretroviral-treated patients.
C1 [Giralt, Marta] Univ Barcelona, Fac Biol, Dept Biochem & Mol Biol, E-08028 Barcelona, Spain.
   [Giralt, Marta; Diaz-Delfin, Julieta; Gallego-Escuredo, Jose M.; Villarroya, Joan; Villarroya, Francesc] Univ Barcelona, Inst Biomed IBUB, E-08028 Barcelona, Spain.
   [Giralt, Marta; Diaz-Delfin, Julieta; Gallego-Escuredo, Jose M.; Villarroya, Joan; Villarroya, Francesc] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nut, Barcelona, Spain.
   [Domingo, Pere] Hosp Santa Creu & Sant Pau, Dept Internal Med, Barcelona, Spain.
   [Villarroya, Joan; Domingo, Pere] Hosp Santa Creu & Sant Pau, Inst Recerca, Barcelona, Spain.
C3 University of Barcelona; University of Barcelona; Instituto de Salud
   Carlos III; Hospital of Santa Creu i Sant Pau; Autonomous University of
   Barcelona; Hospital Universitari Vall d'Hebron; Vall d'Hebron Institut
   de Recerca (VHIR); Hospital of Santa Creu i Sant Pau
RP Giralt, M (corresponding author), Univ Barcelona, Fac Biol, Dept Biochem & Mol Biol, Avda Diagonal 645, E-08028 Barcelona, Spain.
EM mgiralt@ub.edu
RI Domingo, Pere/AAP-7571-2021; Villarroya, Francesc/K-4357-2014;
   Villarroya, Joan/W-4066-2018; Giralt, Marta/A-4756-2013
OI Villarroya, Joan/0000-0002-7859-1109; Villarroya,
   Francesc/0000-0003-1266-9142; GALLEGO-ESCUREDO, JOSE
   MIGUEL/0000-0001-7899-8585; Giralt, Marta/0000-0001-7968-4190
FU Ministerio de Ciencia e Innovacion [SAF2008- 01896]; Instituto de Salud
   Carlos III [PI08/1715]; Red de Investigacion en SIDA [RIS RD06/006]
FX Supported by grants from Ministerio de Ciencia e Innovacion (SAF2008-
   01896), Instituto de Salud Carlos III (PI08/1715) and Red de
   Investigacion en SIDA (RIS RD06/006). Thanks are given to V. Carreno for
   support in the design of the Fig. (1).
CR Agarwal AK, 2002, NAT GENET, V31, P21, DOI 10.1038/ng880
   [Anonymous], 2008, CLIN ENDOCRINOL, V68, P547, DOI 10.1111/j.1365-2265.2007.03095.x
   Asterholm Ingrid Wernstedt, 2007, Drug Discov Today Dis Models, V4, P17
   Barbaro G, 2005, CURR PHARM DESIGN, V11, P1805, DOI 10.2174/1381612053764869
   Barbaro G, 2007, CURR PHARM DESIGN, V13, P2208, DOI 10.2174/138161207781039661
   Bastard JP, 2002, LANCET, V359, P1026, DOI 10.1016/S0140-6736(02)08094-7
   Boyd MA, 2006, J INFECT DIS, V194, P642, DOI 10.1086/505709
   Carmona MC, 2002, J BIOL CHEM, V277, P21489, DOI 10.1074/jbc.M201710200
   Caron M, 2004, AIDS, V18, P2127, DOI 10.1097/00002030-200411050-00004
   Colombo C, 2002, DIABETES, V51, P2727, DOI 10.2337/diabetes.51.9.2727
   Cortés VA, 2009, CELL METAB, V9, P165, DOI 10.1016/j.cmet.2009.01.002
   Cutler DA, 2002, BIOCHEM BIOPH RES CO, V291, P522, DOI 10.1006/bbrc.2002.6466
   D'Amico S, 2006, AM J CLIN NUTR, V84, P204, DOI 10.1093/ajcn/84.1.204
   de la Concepción MLR, 2005, ANTIVIR THER, V10, P515
   den Boer MAM, 2006, ARTERIOSCL THROM VAS, V26, P124, DOI 10.1161/01.ATV.0000194073.87647.10
   Djedaini M, 2009, BIOCHEM BIOPH RES CO, V386, P96, DOI 10.1016/j.bbrc.2009.05.148
   Duan SZ, 2007, J CLIN INVEST, V117, P812, DOI 10.1172/JCI28859
   El Hadri K, 2004, J BIOL CHEM, V279, P15130, DOI 10.1074/jbc.M312875200
   Falutz J, 2007, NEW ENGL J MED, V357, P2359, DOI 10.1056/NEJMoa072375
   Fisac C, 2005, AIDS, V19, P917, DOI 10.1097/01.aids.0000171405.46113.bf
   Flint OP, 2009, TOXICOL PATHOL, V37, P65, DOI 10.1177/0192623308327119
   Garg A, 2004, NEW ENGL J MED, V350, P1220, DOI 10.1056/NEJMra025261
   Garg A, 2009, BBA-MOL CELL BIOL L, V1791, P507, DOI 10.1016/j.bbalip.2008.12.014
   Gavrilova O, 2000, J CLIN INVEST, V105, P271, DOI 10.1172/JCI7901
   Giralt M, 2006, ANTIVIR THER, V11, P729
   Giralt M, 2009, PPAR RES, V2009, DOI 10.1155/2009/607902
   Gonzalez-Tome MI, 2008, BMC INFECT DIS, V8, DOI 10.1186/1471-2334-8-144
   Gray SL, 2006, DIABETES, V55, P2669, DOI 10.2337/db06-0389
   Gray SL, 2005, BIOCHEM SOC T, V33, P1053, DOI 10.1042/BST0331053
   Grinspoon S, 2005, NEW ENGL J MED, V352, P48, DOI 10.1056/NEJMra041811
   Guallar JP, 2008, AIDS, V22, P575, DOI 10.1097/QAD.0b013e3282f56b40
   Guo W, 2009, ARTERIOSCL THROM VAS, V29, P2028, DOI 10.1161/ATVBAHA.109.191304
   Hadigaan C, 2003, AM J CLIN NUTR, V77, P490, DOI 10.1093/ajcn/77.2.490
   Hadigan C, 2002, METABOLISM, V51, P1143, DOI 10.1053/meta.2002.34704
   Hadigan C, 2006, J CLIN ENDOCR METAB, V91, P4438, DOI 10.1210/jc.2006-1174
   Haque WA, 2002, J CLIN ENDOCR METAB, V87, P2395, DOI 10.1210/jc.87.5.2395
   Haubrich RH, 2009, AIDS, V23, P1109, DOI 10.1097/QAD.0b013e32832b4377
   Hegele RA, 2007, J LIPID RES, V48, P1433, DOI 10.1194/jlr.R700004-JLR200
   Karelis AD, 2004, J CLIN ENDOCR METAB, V89, P2569, DOI 10.1210/jc.2004-0165
   Kim CA, 2008, J CLIN ENDOCR METAB, V93, P1129, DOI 10.1210/jc.2007-1328
   Koutnikova H, 2003, P NATL ACAD SCI USA, V100, P14457, DOI 10.1073/pnas.2336090100
   Kubota N, 1999, MOL CELL, V4, P597, DOI 10.1016/S1097-2765(00)80210-5
   Lindegaard B, 2007, DIABETES, V56, P2070, DOI 10.2337/db07-0144
   Linhart HG, 2001, P NATL ACAD SCI USA, V98, P12532, DOI 10.1073/pnas.211416898
   Lo JC, 2004, CLIN INFECT DIS, V39, P732, DOI 10.1086/422725
   Magré J, 2001, NAT GENET, V28, P365, DOI 10.1038/ng585
   Mallon PWG, 2005, J INFECT DIS, V191, P1686, DOI 10.1086/429697
   Mantzoros CS, 2009, J CLIN ENDOCR METAB, V94, P1089, DOI 10.1210/jc.2009-0340
   Moitra J, 1998, GENE DEV, V12, P3168, DOI 10.1101/gad.12.20.3168
   Nagy GS, 2003, CLIN INFECT DIS, V36, P795, DOI 10.1086/367859
   Negredo E, 1999, ANTIVIR THER, V4, P23
   Oral EA, 2002, NEW ENGL J MED, V346, P570, DOI 10.1056/NEJMoa012437
   Pajvani UB, 2005, NAT MED, V11, P797, DOI 10.1038/nm1262
   Park JY, 2007, METABOLISM, V56, P508, DOI 10.1016/j.metabol.2006.11.010
   Parker RA, 2005, MOL PHARMACOL, V67, P1909, DOI 10.1124/mol.104.010165
   PECK MD, 1993, LIPIDS, V28, P593, DOI 10.1007/BF02536052
   Pirmohamed M, 2009, CURR OPIN LIPIDOL, V20, P309, DOI 10.1097/MOL.0b013e32832d3bb1
   Reitman ML, 2002, ANNU REV NUTR, V22, P459, DOI 10.1146/annurev.nutr.22.010402.102849
   Reue K, 2006, CURR OPIN CLIN NUTR, V9, P436, DOI 10.1097/01.mco.0000232904.82038.db
   Riddler SA, 2008, NEW ENGL J MED, V358, P2095, DOI 10.1056/NEJMoa074609
   Rietschel P, 2001, J CLIN ENDOCR METAB, V86, P504, DOI 10.1210/jc.86.2.504
   ROSS SR, 1993, GENE DEV, V7, P1318, DOI 10.1101/gad.7.7b.1318
   Rudich A, 2001, DIABETES, V50, P1425, DOI 10.2337/diabetes.50.6.1425
   Savage DB, 2009, DIS MODEL MECH, V2, P554, DOI 10.1242/dmm.002907
   Schoonjans K, 1996, EMBO J, V15, P5336, DOI 10.1002/j.1460-2075.1996.tb00918.x
   Shibuyama S, 2006, CURR PHARM DESIGN, V12, P1075, DOI 10.2174/138161206776055796
   Shimomura I, 1998, GENE DEV, V12, P3182, DOI 10.1101/gad.12.20.3182
   Shimomura I, 1999, NATURE, V401, P73, DOI 10.1038/43448
   Soverini V, 2010, OBES SURG, V20, P295, DOI 10.1007/s11695-009-9999-z
   Sutinen J, 2009, PPAR RES, V2009, DOI 10.1155/2009/373524
   Unger RH, 2010, BBA-MOL CELL BIOL L, V1801, P209, DOI 10.1016/j.bbalip.2009.10.006
   van der Valk M, 2002, J CLIN ENDOCR METAB, V87, P5066, DOI 10.1210/jc.2002-020892
   van Leth F, 2004, PLOS MED, V1, P64, DOI 10.1371/journal.pmed.0010019
   van Vonderen MGA, 2010, JAIDS-J ACQ IMM DEF, V53, P186, DOI 10.1097/QAI.0b013e3181c190f4
   Villarroya F, 2007, INT J OBESITY, V31, P1763, DOI 10.1038/sj.ijo.0803698
   Villarroya F, 2005, TRENDS PHARMACOL SCI, V26, P88, DOI 10.1016/j.tips.2004.12.005
   Virtue S, 2010, BBA-MOL CELL BIOL L, V1801, P338, DOI 10.1016/j.bbalip.2009.12.006
   WANG ND, 1995, SCIENCE, V269, P1108, DOI 10.1126/science.7652557
   Wanke C, 1999, AIDS, V13, P2099, DOI 10.1097/00002030-199910220-00013
   Wojtanik KM, 2009, J LIPID RES, V50, P1068, DOI 10.1194/jlr.M800491-JLR200
   Wu XD, 2010, GASTROENTEROLOGY, V138, P197, DOI 10.1053/j.gastro.2009.08.054
   Yki-Jarvinen H, 2004, NEW ENGL J MED, V351, P1106, DOI 10.1056/NEJMra041001
NR 82
TC 20
Z9 23
U1 0
U2 1
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2010
VL 16
IS 30
BP 3372
EP 3378
DI 10.2174/138161210793563527
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 688BP
UT WOS:000284824500005
PM 20687888
DA 2025-06-11
ER

PT J
AU Tükel, HC
   Delilbasi, E
AF Tukel, Huseyin Can
   Delilbasi, Ertan
TI Effects of metabolic syndrome on jawbones and bone metabolic markers in
   sucrose-fed rats
SO ODONTOLOGY
LA English
DT Article
DE Mandible; Metabolic syndrome; Bone mineral density; Bone-specific
   tartrate-resistant acid phosphatase-5b; Sucrose
ID MINERAL DENSITY; OXIDATIVE STRESS; ALKALINE-PHOSPHATASE;
   INSULIN-RESISTANCE; ALVEOLAR BONE; HIGH-FAT; DIET; INFLAMMATION;
   FRUCTOSE; DISEASE
AB The aim of this study was to investigate the effects of metabolic syndrome (MetS) on bone mineral density (BMD) and microstructure of jawbones, and circulating bone metabolic markers. MetS was induced in male Wistar rats by a 16-week high-sucrose drinking water diet. Mandibles were analyzed for BMD and microstructure by standard radiographs and X-ray diffraction. BMD of three different regions of mandible in MetS group was significantly lower compared to control group. The diffraction intensity of mandibular bone in MetS group was significantly decreased (8.2%) compared to control group; however, crystallite radiuses of mandibular bone samples in both groups were not significantly different. In MetS group, serum bone-specific tartrate-resistant acid phosphatase-5b (TRACP-5b) activity was significantly increased (47%), whereas bone-specific alkaline phosphatase (BALP) activity was significantly decreased (44%) compared to control group. The serum magnesium level in MetS rats (1.82 +/- 0.27 mg dL(-1)) was lower than that of controls (2.11 +/- 0.16 mg dL(-1)). Rats with MetS had significantly higher serum calcium level (9.70 +/- 0.41 mg dL(-1)) than the controls (9.21 +/- 0.50 mg dL(-1)). Overall data suggested that MetS is associated with a significant decrease in BMD and slight deterioration in microcrystallite structure of the jawbones. The changes in TRACP-5b and BALP activities and serum Ca2+ and Mg2+ concentrations also support these findings at a biochemical level.
C1 [Tukel, Huseyin Can] Cukurova Univ, Fac Dent, Dept Oral & Maxillofacial Surg, TR-01330 Adana, Turkey.
   [Delilbasi, Ertan] Gazi Univ, Fac Dent, Dept Oral & Maxillofacial Surg, Ankara, Turkey.
C3 Cukurova University; Gazi University
RP Tükel, HC (corresponding author), Cukurova Univ, Fac Dent, Dept Oral & Maxillofacial Surg, TR-01330 Adana, Turkey.
EM cantukel@gmail.com
RI tükel, hüseyin/J-9250-2018
CR Bagi CM, 2018, CALCIFIED TISSUE INT, V102, P683, DOI 10.1007/s00223-017-0367-z
   Çakur B, 2009, DENTOMAXILLOFAC RAD, V38, P255, DOI 10.1259/dmfr/22559806
   Campos RMS, 2012, ENDOCRINE, V42, P146, DOI 10.1007/s12020-012-9613-3
   Cheung CL, 2013, J CLIN ENDOCR METAB, V98, P3856, DOI 10.1210/jc.2013-2024
   Faloni APD, 2011, CALCIFIED TISSUE INT, V88, P63, DOI 10.1007/s00223-010-9418-4
   DEFRONZO RA, 1991, DIABETES CARE, V14, P173, DOI 10.2337/diacare.14.3.173
   Dutta Mk, 2012, Med J Armed Forces India, V68, P48, DOI 10.1016/S0377-1237(11)60120-2
   Ferder L, 2006, CURR HYPERTENS REP, V8, P191, DOI 10.1007/s11906-006-0050-7
   Fujita Yuko, 2015, BMC Obes, V3, P1, DOI 10.1186/s40608-016-0082-8
   Goldenberg R, 2013, CAN J DIABETES, V37, pS8, DOI 10.1016/j.jcjd.2013.01.011
   Greco EA, 2010, INT J CLIN PRACT, V64, P817, DOI 10.1111/j.1742-1241.2009.02301.x
   Guerrero-Romero F, 2006, DIABETES-METAB RES, V22, P471, DOI 10.1002/dmrr.644
   Halleen JM, 2006, CLIN LAB, V52, P499
   Hernández JL, 2010, MENOPAUSE, V17, P955, DOI 10.1097/gme.0b013e3181e39a15
   Felice JI, 2017, DIABETES RES CLIN PR, V126, P202, DOI 10.1016/j.diabres.2017.02.011
   Felice JI, 2014, METABOLISM, V63, P296, DOI 10.1016/j.metabol.2013.11.002
   Kanazawa I, 2009, J CLIN ENDOCR METAB, V94, P45, DOI 10.1210/jc.2008-1455
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kaye EK, 2016, J DENT RES, V95, P822, DOI 10.1177/0022034516641053
   Kim HY, 2010, CALCIFIED TISSUE INT, V86, P350, DOI 10.1007/s00223-010-9347-2
   Kim MK, 2010, ATHEROSCLEROSIS, V212, P674, DOI 10.1016/j.atherosclerosis.2010.07.005
   Lee K, 2015, CALCIFIED TISSUE INT, V97, P487, DOI 10.1007/s00223-015-0033-2
   Li Y, 2015, J DENT RES, V94, P362, DOI 10.1177/0022034514561658
   Matsuzawa-Nagata N, 2008, METABOLISM, V57, P1071, DOI 10.1016/j.metabol.2008.03.010
   Mavropoulos A, 2007, J BONE MINER RES, V22, P403, DOI 10.1359/JBMR.061208
   Mizoguchi I, 2013, JPN DENT SCI REV, V49, P139, DOI 10.1016/j.jdsr.2013.07.004
   Montalvany-Antonucci CC, 2018, ARCH ORAL BIOL, V86, P101, DOI 10.1016/j.archoralbio.2017.11.013
   Muka T, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0129116
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Ohnishi T, 2009, J PERIODONTAL RES, V44, P43, DOI 10.1111/j.1600-0765.2007.01060.x
   ROSALKI SB, 1984, CLIN CHEM, V30, P1182
   Saltevo J, 2011, EUR J ENDOCRINOL, V165, P429, DOI 10.1530/EJE-11-0066
   Smith BJ, 2006, BONE, V38, P378, DOI 10.1016/j.bone.2005.09.008
   Smith EE, 2000, BIOMED SCI INSTRUM, V395, P385
   Softic S, 2016, DIGEST DIS SCI, V61, P1282, DOI 10.1007/s10620-016-4054-0
   Sun M, 2014, BMC ENDOCR DISORD, V14, DOI 10.1186/1472-6823-14-14
   Szulc P, 2010, J BONE MINER RES, V25, P1446, DOI 10.1002/jbmr.13
   Tanaka M, 2000, J DENT RES, V79, P1907, DOI 10.1177/00220345000790111601
   Tjäderhane L, 1998, J NUTR, V128, P1807, DOI 10.1093/jn/128.10.1807
   Tsanzi E, 2008, BONE, V42, P960, DOI 10.1016/j.bone.2008.01.020
   Tükel HC, 2015, EUR J ORAL SCI, V123, P432, DOI 10.1111/eos.12226
   von Muhlen D, 2007, OSTEOPOROSIS INT, V18, P1337, DOI 10.1007/s00198-007-0385-1
   Yamaguchi T, 2009, BONE, V45, P174, DOI 10.1016/j.bone.2009.05.003
   Yamaoka K, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-138
   Yaturu S, 2009, MED SCI MONITOR, V15, pCR5
   Zhou WH, 2017, RSC ADV, V7, P56220, DOI 10.1039/c7ra07139f
NR 46
TC 6
Z9 8
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1618-1247
EI 1618-1255
J9 ODONTOLOGY
JI Odontology
PD OCT
PY 2019
VL 107
IS 4
BP 457
EP 464
DI 10.1007/s10266-019-00422-w
PG 8
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA IV9WS
UT WOS:000484615000004
PM 30911855
DA 2025-06-11
ER

PT J
AU Ichikawa, J
   Okada, A
   Taguchi, K
   Fujii, Y
   Zuo, L
   Niimi, K
   Hamamoto, S
   Kubota, Y
   Umemoto, Y
   Itoh, Y
   Yasui, T
   Kawai, N
   Tozawa, K
   Kohri, K
AF Ichikawa, Jun
   Okada, Atsushi
   Taguchi, Kazumi
   Fujii, Yasuhiro
   Zuo, Li
   Niimi, Kazuhiro
   Hamamoto, Shuzo
   Kubota, Yasue
   Umemoto, Yukihiro
   Itoh, Yasunori
   Yasui, Takahiro
   Kawai, Noriyasu
   Tozawa, Keiichi
   Kohri, Kenjiro
TI Increased crystal-cell interaction in vitro under co-culture of renal
   tubular cells and adipocytes by in vitro co-culture paracrine systems
   simulating metabolic syndrome
SO UROLITHIASIS
LA English
DT Article
DE Osteopontin; TNF-alpha; Kidney stone; Metabolic syndrome; Paracrine
ID CALCIUM-OXALATE CRYSTALS; ADIPOSE-TISSUE; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; EPITHELIAL-CELLS; OSTEOPONTIN; EXPRESSION; OBESITY;
   ADIPONECTIN; ADHESION
AB We established an experimental co-culture system for renal tubular cells and adipocytes to investigate kidney stone formation mechanisms under metabolic syndrome (MetS) conditions and examined the interaction between these cells morphologically and genetically. M-1s and 3T3-L1s were cultured individually (control, CON), with 24-h culture media from each cell type added to the other cell type (replacement, RP) in 2-layer co-culture dishes for 24 h (transwell, TW). M-1s were then exposed to calcium oxalate monohydrate (COM) crystals, and attached C-14-labeled COM crystals were quantified. Expression of kidney stone- and adipocyte-related genes was analyzed. The radioactivity of adherent COM crystals significantly increased in TW and was relatively higher in RP compared to CON. M-1s demonstrated significant upregulation of adiponectin (Adipoq) in RP and secreted phosphoprotein 1 (Spp1) in TW compared to CON before COM crystal exposure, and significant downregulation of Spp1 in TW and upregulation of tumor necrosis factor (Tnf), interleukin 6 (Il-6), and chemokine (C-C motif) ligand 2 (Ccl2) compared to CON after COM crystal exposure. 3T3-L1s showed significant upregulation of Spp1, Adipoq, Tnf-alpha, and Ccl2 compared to CON. Enzyme-linked immunosorbent assays of co-culture medium revealed significantly increased TNF-alpha in TW. Our results highlight the potential for paracrine interactions between renal tubular cells and adipocytes and suggest that MetS conditions may lead to kidney stone formation.
C1 [Ichikawa, Jun; Okada, Atsushi; Taguchi, Kazumi; Fujii, Yasuhiro; Zuo, Li; Niimi, Kazuhiro; Hamamoto, Shuzo; Kubota, Yasue; Umemoto, Yukihiro; Itoh, Yasunori; Yasui, Takahiro; Kawai, Noriyasu; Tozawa, Keiichi; Kohri, Kenjiro] Nagoya City Univ, Grad Sch Med Sci, Dept Nephrourol, Mizuho Ku, Nagoya, Aichi 4678601, Japan.
C3 Nagoya City University
RP Okada, A (corresponding author), Nagoya City Univ, Grad Sch Med Sci, Dept Nephrourol, Mizuho Ku, 1 Kawasumi, Nagoya, Aichi 4678601, Japan.
EM a-okada@med.nagoya-cu.ac.jp
RI Taguchi, Kazumi/AFU-4486-2022; YASUI, Takahiro/E-6401-2018
OI Okada, Atsushi/0000-0003-2080-3794; Taguchi, Kazumi/0000-0002-3092-5114;
   Yasui, Takahiro/0000-0003-2197-2477
FU Japanese Ministry of Education, Culture, Sports, Science and Technology
   [23249074, 23592374, 23592375, 23791770, 23791774, 23791775, 22591797,
   22791481, 22791479, 22791484, 21791517, 21791520]; Grants-in-Aid for
   Scientific Research [25861443, 24689060, 25462521, 22791484, 23791770,
   25670685, 21791517, 23592375, 22791479, 24659716, 23791775, 23249074,
   23791774, 22791481, 23592374, 24791663, 21791520, 22591797] Funding
   Source: KAKEN
FX We thank Ms. N. Kasuga, Ms. Kawamura, and Ms. Ichikawa for their
   secretarial assistance. This work was partly supported by Grants-in-Aid
   for Scientific Research (Nos. 23249074, 23592374, 23592375, 23791770,
   23791774, 23791775, 22591797, 22791481, 22791479, 22791484, 21791517,
   and 21791520) from the Japanese Ministry of Education, Culture, Sports,
   Science and Technology.
CR Abate N, 2004, KIDNEY INT, V65, P386, DOI 10.1111/j.1523-1755.2004.00386.x
   Adelman RD, 2002, CURR OPIN NEPHROL HY, V11, P331, DOI 10.1097/00041552-200205000-00010
   Aihara K. -I., 2010, CARDIOL RES PRACT, V2011, DOI DOI 10.4061/2011/175381
   Axelsson J, 2008, CURR OPIN NEPHROL HY, V17, P25, DOI 10.1097/MNH.0b013e3282f2905f
   BJORNTORP P, 1988, DIABETES METAB REV, V4, P615, DOI 10.1002/dmr.5610040607
   Borghi L, 1999, KIDNEY INT, V55, P2397, DOI 10.1046/j.1523-1755.1999.00483.x
   Brake DK, 2006, AM J PHYSIOL-CELL PH, V291, pC1232, DOI 10.1152/ajpcell.00008.2006
   Chauvet MC, 2005, J STRUCT BIOL, V151, P12, DOI 10.1016/j.jsb.2005.04.005
   Clark DL, 2011, BJU INT, V107, P318, DOI 10.1111/j.1464-410X.2010.09311.x
   Clark DL, 2009, BJU INT, V103, P1562, DOI 10.1111/j.1464-410X.2008.08260.x
   Coe FL, 2010, UROL RES, V38, P147, DOI 10.1007/s00240-010-0271-8
   Curhan GC, 2007, UROL CLIN N AM, V34, P287, DOI 10.1016/j.ucl.2007.04.003
   Evan AP, 2005, KIDNEY INT, V68, P145, DOI 10.1111/j.1523-1755.2005.00388.x
   Fujii Y, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061343
   Gambaro G, 2004, J NEPHROL, V17, P774
   Golledge J, 2007, ARTERIOSCL THROM VAS, V27, P655, DOI 10.1161/01.ATV.0000255560.49503.4e
   Gustafson B, 2010, J ATHEROSCLER THROMB, V17, P332, DOI 10.5551/jat.3939
   Hirose M, 2010, INT J UROL, V17, P83, DOI 10.1111/j.1442-2042.2009.02410.x
   HOTAMISLIGIL GS, 1995, J CLIN INVEST, V95, P2409, DOI 10.1172/JCI117936
   Itoh Y, 2005, UROL RES, V33, P261, DOI 10.1007/s00240-005-0465-7
   Kent JW, 2004, DIABETES, V53, P2691, DOI 10.2337/diabetes.53.10.2691
   Khan SR, 2002, J UROLOGY, V168, P1173, DOI 10.1016/S0022-5347(05)64621-6
   KOHRI K, 1993, J BIOL CHEM, V268, P15180
   LIESKE JC, 1995, AM J PHYSIOL-RENAL, V268, pF604, DOI 10.1152/ajprenal.1995.268.4.F604
   Maalouf NM, 2007, CLIN J AM SOC NEPHRO, V2, P883, DOI 10.2215/CJN.00670207
   Maric C, 1996, AM J PHYSIOL-RENAL, V271, pF1020, DOI 10.1152/ajprenal.1996.271.5.F1020
   Matsuda M, 2002, J BIOL CHEM, V277, P37487, DOI 10.1074/jbc.M206083200
   Okada A, 2008, J BONE MINER RES, V23, P1629, DOI 10.1359/JBMR.080514
   Okada A, 2010, J BONE MINER RES, V25, P2425, DOI 10.1002/jbmr.158
   Okada A, 2009, J BONE MINER RES, V24, P908, DOI [10.1359/JBMR.081245, 10.1359/jbmr.081245]
   Okamoto M, 2010, INT J UROL, V17, P996, DOI 10.1111/j.1442-2042.2010.02661.x
   Reiner AP, 2011, J UROLOGY, V185, P920, DOI 10.1016/j.juro.2010.10.086
   Taylor EN, 2005, JAMA-J AM MED ASSOC, V293, P455, DOI 10.1001/jama.293.4.455
   Udo K, 2010, KIDNEY INT, V78, P60, DOI 10.1038/ki.2010.68
   Umekawa T, 2002, KIDNEY INT, V61, P105, DOI 10.1046/j.1523-1755.2002.00106.x
   Umekawa T, 2009, BJU INT, V104, P115, DOI 10.1111/j.1464-410X.2009.08374.x
   Vuruskan H, 2005, UROL RES, V33, P465, DOI 10.1007/s00240-005-0509-z
   Wajchenberg BL, 2000, ENDOCR REV, V21, P697, DOI 10.1210/er.21.6.697
   West B, 2008, AM J KIDNEY DIS, V51, P741, DOI 10.1053/j.ajkd.2007.12.030
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yamauchi T, 2003, J BIOL CHEM, V278, P2461, DOI 10.1074/jbc.M209033200
   Yamauchi T, 2001, NAT MED, V7, P941, DOI 10.1038/90984
   Yasui T, 2002, INT J UROL, V9, P100, DOI 10.1046/j.1442-2042.2002.00429.x
   Yasui T, 2007, SCAND J UROL NEPHROL, V41, P419, DOI 10.1080/00365590701318296
   Zeyda M, 2011, ENDOCRINOLOGY, V152, P2219, DOI 10.1210/en.2010-1328
NR 45
TC 12
Z9 13
U1 0
U2 16
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2194-7228
EI 2194-7236
J9 UROLITHIASIS
JI Urolithiasis
PD FEB
PY 2014
VL 42
IS 1
BP 17
EP 28
DI 10.1007/s00240-013-0612-5
PG 12
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 302SJ
UT WOS:000330624900003
PM 24162953
DA 2025-06-11
ER

PT J
AU Mure, K
   Maeda, S
   Mukoubayashi, C
   Mugitani, K
   Iwane, M
   Kinoshita, F
   Mohara, O
   Takeshita, T
AF Mure, Kanae
   Maeda, Shinya
   Mukoubayashi, Chizu
   Mugitani, Kouichi
   Iwane, Masataka
   Kinoshita, Fujihisa
   Mohara, Osamu
   Takeshita, Tatsuya
TI Habitual coffee consumption inversely associated with metabolic
   syndrome-related biomarkers involving adiponectin
SO NUTRITION
LA English
DT Article
DE Coffee; Metabolic syndrome; Visceral fat area; Adiponectin; Subcutaneous
   fat area
ID GLUCOSE-METABOLISM; INSULIN-RESISTANCE; OXIDATIVE STRESS; TEA
   CONSUMPTION; GREEN TEA; RISK; INFLAMMATION; METAANALYSIS; DISEASE;
   HEALTH
AB Objectives: The goal of this cross-sectional study was to assess whether habitual coffee consumption shows beneficial association with metabolic syndrome (MetS) in adults.
   Methods: The association of coffee consumption and MetS-related biomarkers including visceral fat area (VFA) and subcutaneous fat area (SFA), total serum adiponectin (T-Ad), low-molecular-weight serum adiponectin (LMW-AD), medium-molecular-weight serum adiponectin (MMW-Ad), and high-molecular-weight serum adiponectin (HMW-Ad) levels were analyzed among 364 Japanese men (36-61 y old) using two models of multivariate regression analyses; model 1 (adjusted for age, alcohol drinking, smoking, and walking status) and model 2 (adjusted for body mass index in addition to model I analysis). Participants were categorized into two groups according to their MetS risk score (raised blood pressure and hemoglobin A(1c) levels, and reduced high-density lipoprotein cholesterol levels).
   Results: Both light (1-3 cups/d) and moderate (>= 4 cups/d) coffee consumption showed significant inverse associations with VFA and VFA/SFA ratio (P < 0.0001). Moderate coffee consumption showed a favorable tendency toward these associations with T-Ad (P = 0.06) and HMW-Ad (P = 0.07) levels in model 1 analysis. In participants with lower MetS risk score (<= 1), moderate coffee consumption showed significant associations with 1-Ad and HMW-Ad levels (P < 0.05) in both analyses, whereas no significant associations of coffee consumption with adiponectin levels were seen in the men with higher MetS risk scores (>= 2).
   Conclusions: Habitual moderate coffee consumption shows significant inverse associations with MetS-related biomarkers possibly involving adiponectin, which is inversely related to visceral fat accumulation. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Mure, Kanae; Maeda, Shinya; Takeshita, Tatsuya] Wakayama Med Univ, Sch Med, Dept Publ Hlth, Wakayama, Japan.
   [Maeda, Shinya; Mukoubayashi, Chizu; Mugitani, Kouichi; Iwane, Masataka; Kinoshita, Fujihisa; Mohara, Osamu] Wakayama Wellness Fdn, Wakayama, Japan.
C3 Wakayama Medical University
RP Takeshita, T (corresponding author), Wakayama Med Univ, Sch Med, Dept Publ Hlth, Wakayama, Japan.
EM ttakeshi@wakayama-med.ac.jp
OI Takeshita, Tatsuya/0000-0002-8609-6896
FU Ministry of Education, Culture, Sports, Science and Technology, Japan
   [17590524, 21590658]; Grants-in-Aid for Scientific Research [25460811,
   17590524, 21590658] Funding Source: KAKEN
FX A Grant-in-Aid for Scientific Research was received from the Ministry of
   Education, Culture, Sports, Science and Technology, Japan (17590524 and
   21590658).
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
   [Anonymous], OUTL RES NAT HLTH NU
   Arab L, 2010, NUTR CANCER, V62, P271, DOI 10.1080/01635580903407122
   Aso Y, 2006, DIABETES, V55, P1954, DOI 10.2337/db05-1525
   Belza A, 2009, EUR J CLIN NUTR, V63, P57, DOI 10.1038/sj.ejcn.1602901
   Bobbert T, 2005, DIABETES, V54, P2712, DOI 10.2337/diabetes.54.9.2712
   Driessen MT, 2009, EUR J CLIN NUTR, V63, P536, DOI 10.1038/ejcn.2008.6
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Esposito K, 2010, DIABETES RES CLIN PR, V89, P97, DOI 10.1016/j.diabres.2010.04.019
   Fappa E, 2008, NUTRITION, V24, P286, DOI 10.1016/j.nut.2007.11.008
   Fox CS, 2007, CIRCULATION, V116, P39, DOI 10.1161/CIRCULATIONAHA.106.675355
   Freedman ND, 2012, NEW ENGL J MED, V366, P1891, DOI 10.1056/NEJMoa1112010
   Gans JMD, 2010, ARTERIOSCL THROM VAS, V30, P1665, DOI 10.1161/ATVBAHA.109.201939
   Geleijnse JM, 2008, VASC HEALTH RISK MAN, V4, P963
   Gletsu-Miller N, 2009, OBESITY, V17, P439, DOI 10.1038/oby.2008.542
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Hanhineva K, 2010, INT J MOL SCI, V11, P1365, DOI 10.3390/ijms11041365
   Hayashi T, 2008, DIABETES, V57, P1269, DOI 10.2337/db07-1378
   Hino A, 2007, DIABETES RES CLIN PR, V76, P383, DOI 10.1016/j.diabres.2006.09.033
   Hoelzl C, 2010, MOL NUTR FOOD RES, V54, P1722, DOI 10.1002/mnfr.201000048
   Imatoh T, 2011, EUR J NUTR, V50, P279, DOI 10.1007/s00394-010-0136-5
   Kalthoff S, 2010, GASTROENTEROLOGY, V139, P1699, DOI 10.1053/j.gastro.2010.06.048
   Kashiwagi A, 2012, J DIABETES INVEST, V3, P39, DOI 10.1111/j.2040-1124.2012.00207.x
   Kempf K, 2010, AM J CLIN NUTR, V91, P950, DOI 10.3945/ajcn.2009.28548
   Kotani Kazuhiko, 2008, Diabetes Care, V31, pe47, DOI 10.2337/dc08-0186
   Lamb RE, 2008, INT J CLIN PRACT, V62, P1087, DOI 10.1111/j.1742-1241.2008.01789.x
   Marques-Vidal P, 2010, CLIN ENDOCRINOL, V72, P38, DOI 10.1111/j.1365-2265.2009.03628.x
   Matsuura H, 2012, J EPIDEMIOL, V22, P160, DOI 10.2188/jea.JE20110068
   Matsuzawa Y, 2006, NAT CLIN PRACT CARD, V3, P35, DOI 10.1038/ncpcardio0380
   Maury E, 2010, MOL CELL ENDOCRINOL, V314, P1, DOI 10.1016/j.mce.2009.07.031
   McNeill AM, 2005, DIABETES CARE, V28, P385, DOI 10.2337/diacare.28.2.385
   Ninomiya JK, 2004, CIRCULATION, V109, P42, DOI 10.1161/01.CIR.0000108926.04022.0C
   Osaki Y, 2012, CANCER EPIDEMIOL, V36, P141, DOI 10.1016/j.canep.2011.03.007
   Pais R, 2009, WORLD J GASTROENTERO, V15, P5141, DOI 10.3748/wjg.15.5141
   Rebello SA, 2011, NUTR J, V10, DOI 10.1186/1475-2891-10-61
   Sartorelli DS, 2010, AM J CLIN NUTR, V91, P1002, DOI 10.3945/ajcn.2009.28741
   Shen T, 2010, BIOL PHARM BULL, V33, P1159, DOI 10.1248/bpb.33.1159
   Sirtori CR, 2009, NUTR RES REV, V22, P244, DOI 10.1017/S0954422409990187
   van Dam RM, 2005, JAMA-J AM MED ASSOC, V294, P97, DOI 10.1001/jama.294.1.97
   Van der Zwan LP, 2010, HYPERTENSION, V55, P1366, DOI 10.1161/HYPERTENSIONAHA.109.147231
   Vincent HK, 2006, INT J OBESITY, V30, P400, DOI 10.1038/sj.ijo.0803177
   Whitehead JP, 2006, DIABETES OBES METAB, V8, P264, DOI 10.1111/j.1463-1326.2005.00510.x
   Williams CJ, 2008, DIABETES CARE, V31, P504, DOI 10.2337/dc07-1952
   Wu JN, 2009, INT J CARDIOL, V137, P216, DOI 10.1016/j.ijcard.2008.06.051
   Yamashita K, 2012, NUTR DIABETES, V2, DOI 10.1038/nutd.2012.6
   Zhang Y, 2011, NUTR METAB CARDIOVAS, V21, P418, DOI 10.1016/j.numecd.2009.10.020
   Zhang ZZ, 2011, AM J CLIN NUTR, V93, P1212, DOI 10.3945/ajcn.110.004044
NR 48
TC 27
Z9 28
U1 0
U2 13
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD JUL-AUG
PY 2013
VL 29
IS 7-8
BP 982
EP 987
DI 10.1016/j.nut.2013.01.011
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 172UF
UT WOS:000321029700010
PM 23602227
DA 2025-06-11
ER

PT J
AU Chiu, CC
   Chen, CH
   Huang, MC
   Chen, PY
   Tsai, CJ
   Lu, ML
AF Chiu, Chih-Chiang
   Chen, Chun-Hsin
   Huang, Ming-Chyi
   Chen, Po-Yu
   Tsai, Chang-Jer
   Lu, Mong-Liang
TI The Relationship Between Serum Uric Acid Concentration and Metabolic
   Syndrome in Patients With Schizophrenia or Schizoaffective Disorder
SO JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
LA English
DT Article
DE metabolic syndrome; uric acid; hyperuricemia; schizophrenia;
   antipsychotics
ID OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; CAROTID ATHEROSCLEROSIS;
   INSULIN-RESISTANCE; RISK-FACTORS; HYPERURICEMIA; PREVALENCE;
   ASSOCIATION; POPULATION; GLUCOSE
AB Higher prevalence rates of metabolic syndrome (MetS) in patients with schizophrenia are getting more and more attention. Uric acid (UA) has been frequently reported to be associated with MetS in the general population. Sex difference in this relationship is inconsistent. As a selective antioxidant, UA has also been found to be reduced in patients with schizophrenia, and this effect may be prominent in men. With the inconsistent presentations, higher rate of MetS but possible lower UA concentrations, the aim of this study was to investigate the relationship by sexes between serum UA concentrations and prevalence of MetS in patients with schizophrenia or schizoaffective disorder. A total of 637 patients, 342 male and 295 female, were enrolled from 36 psychiatric rehabilitation institutions. Cross-sectional anthropometrical data, biochemical analysis, and serum UA were measured. Serum UA concentrations were divided into quartiles by sexes. Modified National Cholesterol Education Program Adult Treatment Panel III criteria for Asians were used as diagnosis of MetS. After adjustment, higher UA concentrations are associated with hypertriglyceridemia, low high-density lipoprotein cholesterol level, and high blood pressure in men and with hypertriglyceridemia in women. Significantly higher odds ratios for MetS in the UA third (4.02; 95% confidence interval, 1.33-12.1) and fourth quartiles (9.28; 95% confidence interval, 2.90-29.8) compared with the lowest quartile were found in men but not in women after adjustment. These results suggest that lower UA concentrations in male patients with schizophrenia or schizoaffective disorder are associated with lower risk of MetS.
C1 [Chen, Chun-Hsin; Lu, Mong-Liang] Taipei Med Univ, Wan Fang Hosp, Dept Psychiat, Taipei 116, Taiwan.
   [Chiu, Chih-Chiang; Huang, Ming-Chyi; Chen, Po-Yu; Tsai, Chang-Jer] Taipei City Hosp, Taipei City Psychiat Ctr, Dept Psychiat, Taipei, Taiwan.
   [Chiu, Chih-Chiang; Chen, Chun-Hsin; Huang, Ming-Chyi; Lu, Mong-Liang] Taipei Med Univ, Coll Med, Sch Med, Dept Psychiat, Taipei, Taiwan.
   [Chiu, Chih-Chiang] Kings Coll London, Inst Psychiat, London WC2R 2LS, England.
   [Tsai, Chang-Jer] Natl Chengchi Univ, Inst Neurosci, Taipei 11623, Taiwan.
C3 Taipei Medical University; Taipei Municipal WanFang Hospital; Taipei
   City Hospital; Taipei Medical University; University of London; King's
   College London; National Chengchi University
RP Lu, ML (corresponding author), Taipei Med Univ, Wan Fang Hosp, Dept Psychiat, 111 Section 3,Hsin Long Rd, Taipei 116, Taiwan.
EM mongliang@hotmail.com
RI Huang, Ming-Chyi/W-9515-2019; Chen, Yi-Hsuan/ABF-8054-2020
OI Lu, Mong-Liang/0000-0003-3184-6554
FU Taipei City Government, Taipei Medical University-Wan Fang Hospital
   [101wf-eva-13]; National Science Council [NSC96-2628-B-038-031-MY3,
   NSC98-2314-B-532-001-MY3, NSC99-2314-B-038-020-MY3]; National Health
   Research Institute, Taiwan [NHRI-EX99-9741PI]
FX This study was supported by grants from Taipei City Government, Taipei
   Medical University-Wan Fang Hospital (101wf-eva-13), National Science
   Council (NSC96-2628-B-038-031-MY3, NSC98-2314-B-532-001-MY3, and
   NSC99-2314-B-038-020-MY3), and National Health Research Institute
   (NHRI-EX99-9741PI), Taiwan.
CR Allison DB, 1999, AM J PSYCHIAT, V156, P1686
   BECKER BF, 1993, FREE RADICAL BIO MED, V14, P615, DOI 10.1016/0891-5849(93)90143-I
   Bhole V, 2010, AM J MED, V123, P957, DOI 10.1016/j.amjmed.2010.03.027
   Bitanihirwe BKY, 2011, NEUROSCI BIOBEHAV R, V35, P878, DOI 10.1016/j.neubiorev.2010.10.008
   Chakraborti A, 2007, BEHAV BRAIN RES, V179, P321, DOI 10.1016/j.bbr.2007.02.018
   Chen LK, 2008, MATURITAS, V59, P55, DOI 10.1016/j.maturitas.2007.10.006
   Chien KL, 2005, ATHEROSCLEROSIS, V183, P147, DOI 10.1016/j.atherosclerosis.2005.01.018
   Choi HK, 2007, AM J MED, V120, P442, DOI 10.1016/j.amjmed.2006.06.040
   Cohn T, 2004, CAN J PSYCHIAT, V49, P753, DOI 10.1177/070674370404901106
   COOK DG, 1986, POSTGRAD MED J, V62, P1001, DOI 10.1136/pgmj.62.733.1001
   Dadheech Gora, 2008, Indian J Psychiatry, V50, P16, DOI 10.4103/0019-5545.39753
   De Hert M, 2006, SCHIZOPHR RES, V88, P222, DOI 10.1016/j.schres.2006.07.025
   De Luca G, 2012, NUTR METAB CARDIOVAS, V22, P426, DOI 10.1016/j.numecd.2010.08.005
   FACCHINI F, 1991, JAMA-J AM MED ASSOC, V266, P3008, DOI 10.1001/jama.266.21.3008
   Feig DI, 2008, NEW ENGL J MED, V359, P1811, DOI 10.1056/NEJMra0800885
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gagliardi ACM, 2009, ATHEROSCLEROSIS, V202, P11, DOI 10.1016/j.atherosclerosis.2008.05.022
   Golembiewska E, 2005, ARCH MED RES, V36, P32, DOI 10.1016/j.arcmed.2004.09.003
   Grattagliano I, 2008, J NUTR BIOCHEM, V19, P491, DOI 10.1016/j.jnutbio.2007.06.011
   Habif S, 2001, CLIN BIOCHEM, V34, P667, DOI 10.1016/S0009-9120(01)00279-X
   Harish G, 2011, NEUROCHEM INT, V59, P1029, DOI 10.1016/j.neuint.2011.08.024
   Hopps E, 2010, NUTR METAB CARDIOVAS, V20, P72, DOI 10.1016/j.numecd.2009.06.002
   Huang MC, 2009, ACTA PSYCHIAT SCAND, V120, P274, DOI 10.1111/j.1600-0447.2009.01401.x
   Ishizaka N, 2005, ARTERIOSCL THROM VAS, V25, P1038, DOI 10.1161/01.ATV.0000161274.87407.26
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Kang DH, 2005, J AM SOC NEPHROL, V16, P3553, DOI 10.1681/ASN.2005050572
   Kang YH, 2008, ENDOCR J, V55, P1093, DOI 10.1507/endocrj.K08E-077
   Kawamoto R, 2006, INTERNAL MED, V45, P605, DOI 10.2169/internalmedicine.45.1661
   Khosla UM, 2005, KIDNEY INT, V67, P1739, DOI 10.1111/j.1523-1755.2005.00273.x
   Kunz M, 2008, PROG NEURO-PSYCHOPH, V32, P1677, DOI 10.1016/j.pnpbp.2008.07.001
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Li XF, 2011, PROG NEURO-PSYCHOPH, V35, P1064, DOI 10.1016/j.pnpbp.2011.03.001
   Lin Shi-Dou, 2006, J Chin Med Assoc, V69, P512
   Liu PW, 2010, METABOLISM, V59, P802, DOI 10.1016/j.metabol.2009.09.027
   Lohsoonthorn V, 2006, ARCH MED RES, V37, P883, DOI 10.1016/j.arcmed.2006.03.008
   Lyketsos CG, 2002, PSYCHOSOMATICS, V43, P24, DOI 10.1176/appi.psy.43.1.24
   Mahadik SP, 2006, INT REV PSYCHIATR, V18, P119, DOI 10.1080/09540260600581993
   McEvoy JP, 2005, SCHIZOPHR RES, V80, P19, DOI 10.1016/j.schres.2005.07.014
   Meyer JM, 2004, SCHIZOPHR RES, V70, P1, DOI 10.1016/j.schres.2004.01.014
   Nagamine T, 2010, NEUROPSYCH DIS TREAT, V6, P281
   Nakano Y, 2010, HUM PSYCHOPHARM CLIN, V25, P139, DOI 10.1002/hup.1102
   Newcomer JW, 2007, J CLIN PSYCHIAT, V68, P8
   Newcomer JW, 2002, ARCH GEN PSYCHIAT, V59, P337, DOI 10.1001/archpsyc.59.4.337
   Numata Takeyuki, 2008, Diabetes Res Clin Pract, V80, pe1, DOI 10.1016/j.diabres.2007.10.031
   Onat A, 2006, AM J HYPERTENS, V19, P1055, DOI 10.1016/j.amjhyper.2006.02.014
   Park SW, 2011, NEUROSCI RES, V69, P283, DOI 10.1016/j.neures.2011.01.004
   Pepe H, 2009, GENDER MED, V6, P587, DOI 10.1016/j.genm.2009.10.001
   Pillai A, 2007, J PSYCHIATR RES, V41, P372, DOI 10.1016/j.jpsychires.2006.01.011
   Reddy R, 2003, SCHIZOPHR RES, V62, P205, DOI 10.1016/S0920-9964(02)00407-3
   Reddy R, 2011, ANTIOXID REDOX SIGN, V15, P2047, DOI 10.1089/ars.2010.3571
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Ryu S, 2007, ANN EPIDEMIOL, V17, P245, DOI 10.1016/j.annepidem.2006.10.001
   Sartori-Valinotti JC, 2007, CLIN EXP PHARMACOL P, V34, P938, DOI 10.1111/j.1440-1681.2007.04643.x
   Sautin YY, 2007, AM J PHYSIOL-CELL PH, V293, pC584, DOI 10.1152/ajpcell.00600.2006
   Singh Om Prakash, 2008, Indian J Psychiatry, V50, P171, DOI 10.4103/0019-5545.43627
   Srivastava N, 2001, PSYCHOPHARMACOLOGY, V158, P140, DOI 10.1007/s002130100860
   Sui XM, 2008, METABOLISM, V57, P845, DOI 10.1016/j.metabol.2008.01.030
   Suvisaari JM, 2007, J CLIN PSYCHIAT, V68, P1045, DOI 10.4088/JCP.v68n0711
   Tamba S, 2008, INTERNAL MED, V47, P1175, DOI 10.2169/internalmedicine.47.0603
   Tan CE, 2004, DIABETES CARE, V27, P1182, DOI 10.2337/diacare.27.5.1182
   Tsouli SG, 2006, METABOLISM, V55, P1293, DOI 10.1016/j.metabol.2006.05.013
   Wilson PWF, 2005, CIRCULATION, V112, P3066, DOI 10.1161/CIRCULATIONAHA.105.539528
   Yao JK, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009508
   Yao JK, 1998, PSYCHIAT RES, V80, P29, DOI 10.1016/S0165-1781(98)00051-1
   Yiginer O, 2008, CLIN RES CARDIOL, V97, P334, DOI 10.1007/s00392-007-0636-3
   Yoo TW, 2005, CIRC J, V69, P928, DOI 10.1253/circj.69.928
NR 66
TC 12
Z9 15
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0271-0749
J9 J CLIN PSYCHOPHARM
JI J. Clin. Psychopharmacol.
PD OCT
PY 2012
VL 32
IS 5
BP 585
EP 592
DI 10.1097/JCP.0b013e3182664e64
PG 8
WC Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Psychiatry
GA 004HI
UT WOS:000308671800002
PM 22926590
DA 2025-06-11
ER

PT J
AU Park, SH
   Lindholm, B
AF Park, Sun-Hee
   Lindholm, Bengt
TI DEFINITION OF METABOLIC SYNDROME IN PERITONEAL DIALYSIS
SO PERITONEAL DIALYSIS INTERNATIONAL
LA English
DT Article; Proceedings Paper
CT 12th Congress of the International-Society-for-Peritoneal-Dialysis
CY JUN 20-24, 2008
CL Istanbul, TURKEY
SP Int Soc Peritoneal Dialysis
DE Metabolic syndrome; chronic kidney disease
ID CHRONIC KIDNEY-DISEASE; STAGE RENAL-DISEASE; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; PROVISIONAL REPORT; DIABETES-MELLITUS;
   BODY-COMPOSITION; LIPID-LEVELS; RISK-FACTOR; MORTALITY
AB Metabolic syndrome (MetS) is defined as a cluster of risk factors for type 2 diabetes and cardiovascular disease; it is also an independent risk factor for developing chronic kidney disease (CKD) in the general population. Therefore, CKD has many similarities and associations with MetS, and the individual risk factors constituting MetS-especially insulin resistance and glucose intolerance, hypertension, dyslipidemia, and obesity-are also common features of the early stages of CKD. In the later stages of CKD, uremia per se and uremic complications such as fluid retention, protein-energy wasting, inflammation, and oxidative stress further contribute to an increase in the prevalence of MetS in CKD patients. In addition, PD patients exposed to glucose-based PD fluids have an increased risk of developing metabolic complications. The broad use of MetS in clinical research has raised the awareness of the public and of individual patients concerning the value of lifestyle interventions. However, the definition and pathogenesis of MetS are still debated, and no standardized definition nor proven prognostic value has been established for MetS as a cluster of risk factors for diabetes or cardiovascular disease in PD patients. Furthermore, considering the paradoxical associations of some of the risk factors in MetS with decreased mortality, another set of risk factors-those specific to patients with uremia (for example, inflammation and malnutrition)-and the appropriate cut-off levels to individual MetS risk factors should be taken account at the same time. Also, the benefit of interventions targeting these risk factors should be clarified in further clinical studies.
C1 [Lindholm, Bengt] Karolinska Univ Hosp, Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum & Renal Med, S-14186 Stockholm, Sweden.
C3 Karolinska Institutet; Karolinska University Hospital
RP Lindholm, B (corresponding author), Karolinska Univ Hosp, Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum & Renal Med, K-56, S-14186 Stockholm, Sweden.
EM bengt.lindholm@ki.se
RI Lindholm, Bengt/P-1334-2017
OI Lindholm, Bengt/0000-0003-4269-4293
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Aslam N, 2002, PERITON DIALYSIS INT, V22, P191
   Axelsson J, 2004, AM J CLIN NUTR, V80, P1222, DOI 10.1093/ajcn/80.5.1222
   Axelsson J, 2005, J RENAL NUTR, V15, P131, DOI 10.1053/j.jrn.2004.09.034
   Axelsson J, 2008, AM J NEPHROL, V28, P669, DOI 10.1159/000121358
   Balkau B, 1999, DIABETIC MED, V16, P442
   Butte NF, 2005, PEDIATR RES, V58, P1243, DOI 10.1203/01.pdr.0000185272.46705.18
   Cameron AJ, 2004, ENDOCRIN METAB CLIN, V33, P351, DOI 10.1016/j.ecl.2004.03.005
   Canbakan M, 2007, RENAL FAILURE, V29, P289, DOI 10.1080/08860220601166271
   Cheng XL, 2008, CHINESE J CHEM, V26, P44, DOI 10.1002/cjoc.200890036
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   DELARUE J, 1994, KIDNEY INT, V45, P1147, DOI 10.1038/ki.1994.152
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Habib AN, 2006, NEPHROL DIAL TRANSPL, V21, P2881, DOI 10.1093/ndt/gfl272
   Honda H, 2007, AM J CLIN NUTR, V86, P633, DOI 10.1093/ajcn/86.3.633
   Iossa S, 2003, BRIT J NUTR, V90, P953, DOI 10.1079/BJN2003000968
   Iseki K, 2002, KIDNEY INT, V61, P1887, DOI 10.1046/j.1523-1755.2002.00324.x
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jager J, 2007, ENDOCRINOLOGY, V148, P241, DOI 10.1210/en.2006-0692
   Johansen KL, 2004, AM J CLIN NUTR, V80, P324, DOI 10.1093/ajcn/80.2.324
   Johnson DW, 2007, NEPHROLOGY, V12, P391, DOI 10.1111/j.1440-1797.2007.00804.x
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   Kahn R, 2008, LANCET, V371, P1892, DOI 10.1016/S0140-6736(08)60731-X
   Kalantar-Zadeh K, 2006, AM J CLIN NUTR, V83, P202
   Kato A, 2003, NEPHROL DIAL TRANSPL, V18, P333, DOI 10.1093/ndt/18.2.333
   Kobayashi S, 2000, NEPHROL DIAL TRANSPL, V15, P65, DOI 10.1093/ndt/15.1.65
   Kovesdy CP, 2007, J AM SOC NEPHROL, V18, P304, DOI 10.1681/ASN.2006060674
   Kurella M, 2005, J AM SOC NEPHROL, V16, P2134, DOI 10.1681/ASN.2005010106
   Kuzuya M, 2007, ATHEROSCLEROSIS, V191, P305, DOI 10.1016/j.atherosclerosis.2006.05.043
   Kylin E., 1923, Zentralbl Inn Med, V44, P105
   Laaksonen DE, 2002, AM J EPIDEMIOL, V156, P1070, DOI 10.1093/aje/kwf145
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   LEE JY, 1991, DIABETES RES CLIN PR, V13, P173, DOI 10.1016/0168-8227(91)90061-H
   Lee SW, 2007, NEPHROL DIAL TRANSPL, V22, P2554, DOI 10.1093/ndt/gfm204
   Lin Y, 2005, J BIOL CHEM, V280, P4617, DOI 10.1074/jbc.M411863200
   Liu YM, 2004, JAMA-J AM MED ASSOC, V291, P451, DOI 10.1001/jama.291.4.451
   Marette A, 2002, CURR OPIN CLIN NUTR, V5, P377, DOI 10.1097/00075197-200207000-00005
   Matsubara K, 2008, BLOOD PURIFICAT, V26, P284, DOI 10.1159/000126925
   Mcdonald SP, 2003, J AM SOC NEPHROL, V14, P2894, DOI 10.1097/01.ASN.0000091587.55159.5F
   McDonald SR, 2004, PERITON DIALYSIS INT, V24, P340
   Morton NM, 2005, DIABETES, V54, P3371, DOI 10.2337/diabetes.54.12.3371
   Ninomiya JK, 2004, CIRCULATION, V109, P42, DOI 10.1161/01.CIR.0000108926.04022.0C
   Panagiotakos DB, 2004, AM HEART J, V147, P106, DOI 10.1016/S0002-8703(03)00442-3
   PEDERSEN O, 1985, KIDNEY INT, V27, P780, DOI 10.1038/ki.1985.80
   Petersen KF, 2003, SCIENCE, V300, P1140, DOI 10.1126/science.1082889
   Ramkumar N, 2005, PERITON DIALYSIS INT, V25, P461
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Sattar N, 2008, LANCET, V371, P1927, DOI 10.1016/S0140-6736(08)60602-9
   Shinohara K, 2002, J AM SOC NEPHROL, V13, P1894, DOI 10.1097/01.ASN.0000019900.87535.43
   Shoji T, 2005, INTERNAL MED, V44, P179, DOI 10.2169/internalmedicine.44.179
   Stenvinkel Peter, 2008, J Am Soc Nephrol, V19, P1062
   Takeguchi F, 2008, THER APHER DIAL, V12, P243, DOI 10.1111/j.1744-9987.2008.00581.x
   Tanaka H, 2006, KIDNEY INT, V69, P369, DOI 10.1038/sj.ki.5000050
   Tsangalis G, 2007, INT J ARTIF ORGANS, V30, P118, DOI 10.1177/039139880703000206
   VAGUE J, 1947, PRESSE MED, V55, P339
   Vasselai P, 2008, J RENAL NUTR, V18, P363, DOI 10.1053/j.jrn.2007.12.005
   Wang XN, 2006, ENDOCRINOLOGY, V147, P4160, DOI 10.1210/en.2006-0251
   Wannamethee SG, 2005, ARCH INTERN MED, V165, P2644, DOI 10.1001/archinte.165.22.2644
   Young Daniel O, 2007, Hemodial Int, V11, P86
   Zhe XW, 2008, AM J NEPHROL, V28, P641, DOI 10.1159/000117813
NR 63
TC 31
Z9 34
U1 0
U2 2
PU MULTIMED INC
PI TORONTO
PA 66 MARTIN ST, TORONTO, ON L9T 2R2, CANADA
SN 0896-8608
J9 PERITON DIALYSIS INT
JI Perit. Dial. Int.
PD FEB
PY 2009
VL 29
SU 2
BP S137
EP S144
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Urology & Nephrology
GA 415ME
UT WOS:000263937100027
PM 19270203
DA 2025-06-11
ER

PT J
AU Mora-Ortiz, M
   Yubero-Serrano, EM
   Priego-Capote, F
   Gutierrez-Mariscal, FM
   Alcala-Diaz, JF
   Torres-Peña, JD
   de-Larriva, APA
   Delgado-Lista, J
   Perez-Martinez, P
   Roche, HM
   López-Miranda, J
AF Mora-Ortiz, Marina
   Yubero-Serrano, Elena M.
   Priego-Capote, Feliciano
   Gutierrez-Mariscal, Francisco M.
   Alcala-Diaz, Juan F.
   Torres-Pena, Jose D.
   de-Larriva, Antonio P. Arenas
   Delgado-Lista, Javier
   Perez-Martinez, Pablo
   Roche, Helen M.
   Lopez-Miranda, Jose
TI Dietary Lipid Quantity and Quality Modulate the Postprandial Metabolomic
   Profile in Patients with Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; metabolomics; SFA; MUFAs; oxidative stress;
   inflammation
ID PARTIAL LEAST-SQUARES; ADIPOSE-TISSUE; LOW-FAT; DEFINITION; STATE; RISK;
   IDENTIFICATION; LIPGENE
AB The literature on the postprandial metabolic changes in individuals with Metabolic Syndrome (MetS) remains limited, despite the fact that postprandial states represent the most common physiological condition in Western societies. Background/Objectives: The objective of this study was to investigate the plasma metabolomics profile in both fasting and postprandial states following a high-fat challenge in individuals with MetS who consumed diets with varying quantities and qualities of dietary fat over 12 weeks. Methods: Seventy-five patients with MetS (28 males and 47 females) from the Spanish LIPGENE cohort were included in the study. MetS patients were randomly stratified to follow one of four dietary interventions (isoenergetic diets) for a 12-week long-term study. The four diets were high in saturated fatty acids and high in monounsaturated fatty acids (HSFA and HMUFA), low-fat high-complex carbohydrates (LFHCC), and LFHCC supplemented with n-3. The metabolomics analysis of plasma samples was carried out using Liquid Chromatography Time-of-Flight Mass Spectrometry (LC-TOF/MS). Results: We observed a decrease in inflammation biomarkers, including acetylcarnitine and L-carnitine during the fasting state and hexanoyl-L-carnitine and isobutyryl-L-carnitine during the postprandial period, mediated by the replacement of HSFA with HMUFA. Additionally, antioxidant compounds such as 4-hydroxybenzaldehyde and L-valine were expressed at higher levels after consumption of the HMUFA diet compared to the HSFA diet. HSFA also presented altered levels of phosphatidylcholine, a metabolite previously linked with insulin resistance. Conclusions: These findings suggest that replacing HSFA with HMUFA may reduce inflammation and improve antioxidant profiles, supporting the potential for tailored dietary interventions in individuals with MetS.
C1 [Mora-Ortiz, Marina; Yubero-Serrano, Elena M.; Gutierrez-Mariscal, Francisco M.; Alcala-Diaz, Juan F.; Torres-Pena, Jose D.; de-Larriva, Antonio P. Arenas; Delgado-Lista, Javier; Perez-Martinez, Pablo; Lopez-Miranda, Jose] Reina Sofia Univ Hosp, Internal Med Unit, Lipids & Atherosclerosis Unit, Cordoba 14004, Spain.
   [Mora-Ortiz, Marina; Yubero-Serrano, Elena M.; Gutierrez-Mariscal, Francisco M.; Alcala-Diaz, Juan F.; Torres-Pena, Jose D.; de-Larriva, Antonio P. Arenas; Delgado-Lista, Javier; Perez-Martinez, Pablo; Lopez-Miranda, Jose] Maimonides Biomed Res Inst Cordoba IMIBIC, Cordoba 14004, Spain.
   [Mora-Ortiz, Marina; Yubero-Serrano, Elena M.; Gutierrez-Mariscal, Francisco M.; Alcala-Diaz, Juan F.; Torres-Pena, Jose D.; de-Larriva, Antonio P. Arenas; Delgado-Lista, Javier; Perez-Martinez, Pablo; Lopez-Miranda, Jose] Univ Cordoba, Dept Med & Surg Sci, Cordoba 14071, Spain.
   [Mora-Ortiz, Marina; Yubero-Serrano, Elena M.; Gutierrez-Mariscal, Francisco M.; Alcala-Diaz, Juan F.; Torres-Pena, Jose D.; de-Larriva, Antonio P. Arenas; Delgado-Lista, Javier; Perez-Martinez, Pablo; Lopez-Miranda, Jose] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERObn, Madrid 28029, Spain.
   [Yubero-Serrano, Elena M.] CSIC, Dept Food & Hlth, Inst Grasa, Seville 28006, Spain.
   [Priego-Capote, Feliciano] Univ Cordoba, Dept Quim Analit & Nanoquim, Edificio Marie Curie Anexo, Cordoba 14071, Spain.
   [Priego-Capote, Feliciano] Inst Salud Carlos III, CIBER Fragilidad & Envejecimiento Saludable CIBERF, Madrid 28029, Spain.
   [Roche, Helen M.] Univ Coll Dublin, Conway Inst, Sch Publ Hlth, Nutrigen Res Grp, Dublin D04 V1W8, Ireland.
   [Roche, Helen M.] Queens Univ Belfast, Inst Global Food Secur, Belfast BT7 1NN, North Ireland.
C3 Universidad de Cordoba; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Consejo Superior de
   Investigaciones Cientificas (CSIC); CSIC - Instituto de la Grasa (IG);
   Universidad de Cordoba; Instituto de Salud Carlos III; University
   College Dublin; Queens University Belfast
RP Mora-Ortiz, M; López-Miranda, J (corresponding author), Reina Sofia Univ Hosp, Internal Med Unit, Lipids & Atherosclerosis Unit, Cordoba 14004, Spain.; Mora-Ortiz, M; López-Miranda, J (corresponding author), Maimonides Biomed Res Inst Cordoba IMIBIC, Cordoba 14004, Spain.; Mora-Ortiz, M; López-Miranda, J (corresponding author), Univ Cordoba, Dept Med & Surg Sci, Cordoba 14071, Spain.; Mora-Ortiz, M; López-Miranda, J (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERObn, Madrid 28029, Spain.
EM marina.mora@imibic.org; elena.yubero@imibic.org; q72prcaf@uco.es;
   francisco.gutierrez@imibic.org; juanf.alcala.sspa@juntadeandalucia.es;
   h42topej@uco.es; h52arlaa@uco.es; md1delij@uco.es; pablopermar@yahoo.es;
   helen.roche@ucd.ie; jlopezmir@uco.es
RI Delgado-Lista, Javier/KAM-7412-2024; Arenas, Antonio/Y-9969-2019;
   Yubero-Serrano, Elena/H-4832-2013; Gutierrez-Mariscal, Francisco
   M/AAX-3185-2021; Lopez-Miranda, Jose/Y-8306-2019; Alcala-Diaz,
   Juan/Q-4455-2019; Peña, José/ABH-3312-2020; Gutierrez Mariscal,
   Francisco Miguel/F-9804-2016; Priego-Capote, Feliciano/C-7977-2014;
   Perez Martinez, Pablo/AEL-6176-2022
OI Gutierrez Mariscal, Francisco Miguel/0000-0003-3353-2188; Priego-Capote,
   Feliciano/0000-0003-0697-719X; Delgado Lista, Francisco
   Javier/0000-0002-2982-2716; Perez Martinez, Pablo/0000-0001-7716-8117;
   Roche, Helen/0000-0002-0628-3318; Mora-Ortiz, Marina/0000-0002-6662-2932
FU LIPGENE-an EU 6th Framework Program Integrated Project [FOOD-CT- 39
   03-505944]; LIPGENE-an EU; Ministry of Economy and Competitiveness
   [PIE14/000015/5]; Carlos III Institute of Health, Spain; Directorate
   General for Assessment and Promotion of Research; EU's European Regional
   Development Fund; Carlos III Institute of Health, Madrid, Spain
FX The study has been supported by LIPGENE-an EU 6th Framework Program
   Integrated Project (FOOD-CT- 39 03-505944). The study was also
   co-financed by the Ministry of Economy and Competitiveness
   (AGL2012-39615/ALI) and the Carlos III Institute of Health, Spain
   (PIE14/000015/5), and by the Directorate General for Assessment and
   Promotion of Research and the EU's European Regional Development Fund.
   CIBEROBN is an initiative of the Carlos III Institute of Health, Madrid,
   Spain.
CR Adams SH, 2011, ADV NUTR, V2, P445, DOI 10.3945/an.111.000737
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Avramoglu RK, 2006, CLIN CHIM ACTA, V368, P1, DOI 10.1016/j.cca.2005.12.026
   Bountagladou OG, 2010, FOOD RES INT, V43, P2014, DOI 10.1016/j.foodres.2010.05.021
   Bylesjö M, 2006, J CHEMOMETR, V20, P341, DOI 10.1002/cem.1006
   Camargo A, 2017, EUR J NUTR, V56, P1621, DOI 10.1007/s00394-016-1208-y
   Cao HM, 2008, CELL, V134, P933, DOI 10.1016/j.cell.2008.07.048
   Cloarec O, 2005, ANAL CHEM, V77, P1282, DOI 10.1021/ac048630x
   Cojocaru E., 2014, Health, V6, P2313, DOI 10.4236/health.2014.617266
   Cruz-Teno C, 2012, MOL NUTR FOOD RES, V56, P854, DOI 10.1002/mnfr.201200096
   Cuturic M, 2016, WORLD J BIOL PSYCHIA, V17, P475, DOI 10.1080/15622975.2016.1178803
   Fallaize R, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-05802-2
   Garcia-Rios A, 2013, CURR VASC PHARMACOL, V11, P920, DOI 10.2174/15701611113116660172
   Grundy SM, 2004, ARTERIOSCL THROM VAS, V24, pE13, DOI 10.1161/01.ATV.0000111245.75752.C6
   Gulseth HL, 2019, EUR J ENDOCRINOL, V180, P321, DOI 10.1530/EJE-19-0022
   Hair JF Jr, 2014, EUR BUS REV, V26, P106, DOI 10.1108/EBR-10-2013-0128
   Han N, 2018, NUTR METAB, V15, DOI 10.1186/s12986-018-0247-1
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Jiménez-Gómez Y, 2010, J NUTR, V140, P1595, DOI 10.3945/jn.109.120816
   Kistner S, 2019, METABOLITES, V9, DOI 10.3390/metabo9070137
   Lefèbvre P, 1998, DIABETIC MED, V15, pS63, DOI 10.1002/(SICI)1096-9136(1998120)15:4+<S63::AID-DIA737>3.3.CO;2-Z
   Lent-Schochet D, 2019, WORLD J DIABETES, V10, P23, DOI 10.4239/wjd.v10.i1.23
   Lent-Schochet D, 2018, HORM MOL BIOL CLIN I, V35, DOI 10.1515/hmbci-2018-0015
   Luce M, 2018, TOXINS, V10, DOI 10.3390/toxins10050205
   MASUDA N, 1981, MICROBIOL IMMUNOL, V25, P1
   Moller DE, 2005, ANNU REV MED, V56, P45, DOI 10.1146/annurev.med.56.082103.104751
   Pallares-Méndez R, 2016, ANN MED, V48, P89, DOI 10.3109/07853890.2015.1137630
   Paniagua JA, 2011, ATHEROSCLEROSIS, V218, P443, DOI 10.1016/j.atherosclerosis.2011.07.003
   Peña-Orihuela P, 2013, J NUTR BIOCHEM, V24, P1717, DOI 10.1016/j.jnutbio.2013.02.012
   Peng DX, 2012, J OPER MANAG, V30, P467, DOI 10.1016/j.jom.2012.06.002
   Perez-Martinez P, 2010, CLIN SCI, V119, P251, DOI 10.1042/CS20100015
   Perez-Martinez P, 2010, ATHEROSCLEROSIS, V209, P533, DOI 10.1016/j.atherosclerosis.2009.09.023
   Phillips C, 2006, CURR OPIN CARDIOL, V21, P185, DOI 10.1097/01.hco.0000221579.25878.11
   Prentice KJ, 2018, EBIOMEDICINE, V27, P200, DOI 10.1016/j.ebiom.2017.12.019
   Ramakrishanan N, 2018, J DIABETES COMPLICAT, V32, P791, DOI 10.1016/j.jdiacomp.2018.05.014
   Sailer M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0063950
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Shaw DI, 2009, BRIT J NUTR, V101, P750, DOI 10.1017/S0007114508039962
   Tierney AC, 2011, INT J OBESITY, V35, P800, DOI 10.1038/ijo.2010.209
   Vega-López S, 2006, AM J CLIN NUTR, V84, P54, DOI 10.1093/ajcn/84.1.54
   Xia JG, 2009, NUCLEIC ACIDS RES, V37, pW652, DOI 10.1093/nar/gkp356
   Xyda SE, 2020, J GERONTOL A-BIOL, V75, P875, DOI 10.1093/gerona/glz141
NR 42
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2024
VL 16
IS 24
AR 4267
DI 10.3390/nu16244267
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA Q4N0B
UT WOS:001384455500001
PM 39770889
OA gold
DA 2025-06-11
ER

PT J
AU Farahani, RA
   Afarideh, M
   Zhu, XY
   Tang, H
   Jordan, KL
   Saadiq, IM
   Ferguson, CM
   Lerman, A
   Textor, SC
   Lerman, LO
   Eirin, A
AF Farahani, Rahele A.
   Afarideh, Mohsen
   Zhu, Xiang-Yang
   Tang, Hui
   Jordan, Kyra L.
   Saadiq, Ishran M.
   Ferguson, Christopher M.
   Lerman, Amir
   Textor, Stephen C.
   Lerman, Lilach O.
   Eirin, Alfonso
TI Percutaneous transluminal renal angioplasty attenuates poststenotic
   kidney mitochondrial damage in pigs with renal artery stenosis and
   metabolic syndrome
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Article
DE hypertension; metabolic syndrome; mitochondria; renal artery stenosis;
   renovascular disease; revascularization
ID ATHEROSCLEROTIC RENOVASCULAR DISEASE; GLOMERULAR-FILTRATION; OXIDATIVE
   STRESS; REVASCULARIZATION; PROTECTS; OUTCOMES; MODEL
AB Percutaneous transluminal renal angioplasty (PTRA) has been used to treat renovascular disease (RVD), a chronic condition characterized by renal ischemia and metabolic abnormalities. Mitochondrial injury has been implicated as a central pathogenic mechanism in RVD, but whether it can be reversed by PTRA remains uncertain. We hypothesized that PTRA attenuates mitochondrial damage, renal injury, and dysfunction in pigs with coexisting renal artery stenosis (RAS) and metabolic syndrome (MetS). Four groups of pigs (n = 6 each) were studied after 16 weeks of diet-induced MetS and RAS (MetS + RAS), MetS + RAS treated 4 weeks earlier with PTRA, and Lean and MetS Sham controls. Single-kidney renal blood flow (RBF) and glomerular filtration rate (GFR) were assessed in vivo with multidetector computed tomography, and renal tubular mitochondrial structure and function and renal injury ex vivo. PTRA successfully restored renal artery patency, but mean arterial pressure remained unchanged. Stenotic kidney RBF and GFR, which fell in MetS + RAS compared to MetS, rose after PTRA. PTRA attenuated MetS + RAS-induced mitochondrial structural abnormalities in tubular cells and peritubular capillary endothelial cells, decreased mitochondrial H(2)0(2) production, and increased renal cytochrome-c oxidase-IV activity and ATP production. PTRA also improved cortical microvascular and peritubular capillary density and ameliorated tubular injury and tubulointerstitial fibrosis in the poststenotic kidney. Importantly, renal mitochondrial damage correlated with poststenotic injury and dysfunction. Renal revascularization attenuated mitochondrial injury and improved renal hemodynamics and function in swine poststenotic kidneys. This study suggests a novel mechanism by which PTRA might be relatively effective in ameliorating mitochondrial damage and improving renal function in coexisting MetS and RAS.
C1 [Farahani, Rahele A.; Afarideh, Mohsen; Zhu, Xiang-Yang; Tang, Hui; Jordan, Kyra L.; Saadiq, Ishran M.; Ferguson, Christopher M.; Textor, Stephen C.; Lerman, Lilach O.; Eirin, Alfonso] Mayo Clin, Div Nephrol & Hypertens, Dept Internal Med, 200 First St SW, Rochester, MN 55905 USA.
   [Lerman, Amir] Mayo Clin, Dept Cardiovasc Dis, Rochester, MN 55905 USA.
C3 Mayo Clinic; Mayo Clinic
RP Eirin, A (corresponding author), Mayo Clin, Div Nephrol & Hypertens, Dept Internal Med, 200 First St SW, Rochester, MN 55905 USA.
EM eirinmassat.alfonso@mayo.edu
RI Balakrishnan, Senthilkumar/J-6908-2014; Lerman, Lilach/M-4962-2017;
   Eirin, Alfonso/N-9873-2013
OI Eirin, Alfonso/0000-0002-3864-9644
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [DK102325, DK104273, DK106427, DK120292, DK122137]
FX National Institute of Diabetes and Digestive and Kidney Diseases,
   Grant/Award Numbers: DK102325, DK104273, DK106427, DK120292, DK122137
CR Bao L, 2009, J NEUROSCI, V29, P9002, DOI 10.1523/JNEUROSCI.1706-09.2009
   Bax L, 2009, ANN INTERN MED, V150, P840, DOI 10.7326/0003-4819-150-12-200906160-00119
   Chade AR, 2013, COMPR PHYSIOL, V3, P817, DOI 10.1002/cphy.c120012
   Conlon PJ, 2001, KIDNEY INT, V60, P1490, DOI 10.1046/j.1523-1755.2001.00953.x
   Cooper CJ, 2014, NEW ENGL J MED, V370, P13, DOI 10.1056/NEJMoa1310753
   Davies MG, 2010, J VASC SURG, V51, P926, DOI 10.1016/j.jvs.2009.09.042
   Dimeloe S, 2019, SCI SIGNAL, V12, DOI 10.1126/scisignal.aav3334
   Ebrahimi B, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0067474
   Eirin A, 2017, TRANSL RES, V184, P45, DOI 10.1016/j.trsl.2017.03.002
   Eirin A, 2016, HYPERTENSION, V68, P401, DOI 10.1161/HYPERTENSIONAHA.116.07849
   Eirin A, 2015, CELL TRANSPLANT, V24, P2041, DOI 10.3727/096368914X685582
   Eirin A, 2014, CARDIOVASC RES, V103, P461, DOI 10.1093/cvr/cvu157
   Eirin A, 2012, HYPERTENSION, V60, P1242, DOI 10.1161/HYPERTENSIONAHA.112.199919
   Eirin A, 2012, CIRC-CARDIOVASC INTE, V5, P720, DOI 10.1161/CIRCINTERVENTIONS.112.972596
   Eirin A, 2011, AM J PHYSIOL-RENAL, V300, pF1394, DOI 10.1152/ajprenal.00697.2010
   Ghazi S, 2020, FASEB J, V34, P8510, DOI 10.1096/fj.202000273R
   Hansen KJ, 2002, J VASC SURG, V36, P443, DOI 10.1067/mva.2002.127351
   Herrmann SMS, 2015, NEPHROL DIAL TRANSPL, V30, P366, DOI 10.1093/ndt/gfu067
   Krier JD, 2001, AM J PHYSIOL-RENAL, V281, pF630, DOI 10.1152/ajprenal.2001.281.4.F630
   Lerman LO, 1999, J AM SOC NEPHROL, V10, P1455
   Lerman LO, 2001, HYPERTENSION, V37, P541, DOI 10.1161/01.HYP.37.2.541
   McFarland R, 2007, CURR TOP DEV BIOL, V77, P113, DOI 10.1016/S0070-2153(06)77005-3
   Nangaku M, 1998, J AM SOC NEPHROL, V9, P590
   Nargesi AA, 2019, J HYPERTENS, V37, P2061, DOI 10.1097/HJH.0000000000002129
   Nargesi AA, 2019, AM J PHYSIOL-RENAL, V317, pF1142, DOI 10.1152/ajprenal.00276.2019
   Pawar AS, 2015, OBESITY, V23, P399, DOI 10.1002/oby.20971
   PFALLER W, 1980, INT J BIOCHEM, V12, P17, DOI 10.1016/0020-711X(80)90035-X
   Pi JB, 2007, DIABETES, V56, P1783, DOI 10.2337/db06-1601
   Ritchie J, 2014, AM J KIDNEY DIS, V63, P186, DOI 10.1053/j.ajkd.2013.07.020
   Schneider CA, 2012, NAT METHODS, V9, P671, DOI 10.1038/nmeth.2089
   Textor SC, 2015, J AM SOC NEPHROL, V26, P2074, DOI 10.1681/ASN.2014121274
   Warner GM, 2012, AM J PHYSIOL-RENAL, V302, pF1455, DOI 10.1152/ajprenal.00645.2011
   Wheatley K, 2009, NEW ENGL J MED, V361, P1953, DOI 10.1056/NEJMoa0905368
   Wilson SH, 1999, CARDIOVASC RES, V44, P601, DOI 10.1016/S0008-6363(99)00225-4
   Zhang X, 2014, HYPERTENSION, V64, P87, DOI 10.1161/HYPERTENSIONAHA.113.02151
   Zhang X, 2013, KIDNEY INT, V84, P767, DOI 10.1038/ki.2013.144
   Zhu XY, 2009, J HYPERTENS, V27, P2063, DOI 10.1097/HJH.0b013e3283300192
   Zhu XY, 2004, ARTERIOSCL THROM VAS, V24, P1854, DOI 10.1161/01.ATV.0000142443.52606.81
NR 38
TC 4
Z9 4
U1 1
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD MAY
PY 2021
VL 236
IS 5
BP 4036
EP 4049
DI 10.1002/jcp.30146
EA NOV 2020
PG 14
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA QO7JN
UT WOS:000585421500001
PM 33151557
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Feng, XM
   Li, LM
   Huang, LL
   Zhang, HY
   Mo, ZN
   Yang, XB
AF Feng, Xiuming
   Li, Longman
   Huang, Lulu
   Zhang, Haiying
   Mo, Zengnan
   Yang, Xiaobo
TI Associations Between Serum Multiple Metals Exposures and Metabolic
   Syndrome: a Longitudinal Cohort Study
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Metabolic syndrome; Co-exposure; Cross-sectional analysis; Longitudinal
   cohort analysis
ID HEAVY-METALS; OXIDATIVE STRESS; NATIONAL-HEALTH; DIETARY TIN;
   WHOLE-BLOOD; RISK-FACTOR; ZINC; MEN; MAGNESIUM; MANGANESE
AB Although many studies have confirmed metabolic syndrome (MetS) is correlated with metal exposures, few studies have elucidated the associations of multiple metals with MetS risk. We aim to explore the relationship between serum 22 metals and MetS. We determined serum 22 metals using ICP-MS and used LASSO regression to select metals independently related with MetS to construct multiple-metals model. We further explored the dose-response relationship between positive metals and MetS by the restricted cubic spline regression. After screening by LASSO regression, serum 11 metals were selected to construct multiple-metals model in cross-sectional analysis, while 5 metals in longitudinal analysis. In the 11-metal model, only tin and zinc were associated with MetS in cross-sectional analysis (ORtin= 2.22, 95% CI:1.43, 3.45; ORzinc= 2.17, 95% CI: 1.42, 3.32; bothP(trend)< 0.05). Besides, the same results were found in the 5-metal model in longitudinal analysis (HRtin= 1.66, 95% CI: 0.87, 3.17; HRzinc= 1.83, 95% CI: 1.07, 3.14; bothP(trend)< 0.05). Moreover, there were positive linear relationships between serum tin and zinc concentrations and the increasing risk of MetS (bothP(overall)< 0.05,Pnon-linearity> 0.05). Furthermore, the interaction between high tin and high zinc was also associated with increasing MetS risk (P-interaction< 0.05). We found that serum tin and zinc were independently and interactively associated with MetS in the southern Chinese men. Our results suggested that high tin and zinc may be the risk factors of MetS.
C1 [Feng, Xiuming; Li, Longman; Huang, Lulu; Zhang, Haiying; Mo, Zengnan; Yang, Xiaobo] Guangxi Med Univ, Ctr Genom & Personalized Med, Nanning, Guangxi, Peoples R China.
   [Feng, Xiuming; Li, Longman; Huang, Lulu; Zhang, Haiying; Mo, Zengnan; Yang, Xiaobo] Guangxi Key Lab Genom & Personalized Med, Nanning, Guangxi, Peoples R China.
   [Feng, Xiuming; Li, Longman; Huang, Lulu; Zhang, Haiying; Mo, Zengnan; Yang, Xiaobo] Guangxi Collaborat Innovat Ctr Genom & Personaliz, Nanning, Guangxi, Peoples R China.
   [Feng, Xiuming; Huang, Lulu; Yang, Xiaobo] Guangxi Med Univ, Sch Publ Hlth, Dept Occupat Hlth & Environm Hlth, Nanning, Guangxi, Peoples R China.
   [Mo, Zengnan] Guangxi Med Univ, Affiliated Hosp 1, Inst Urol & Nephrol, Nanning, Guangxi, Peoples R China.
C3 Guangxi Medical University; Guangxi Medical University; Guangxi Medical
   University
RP Feng, XM (corresponding author), Guangxi Med Univ, Ctr Genom & Personalized Med, Nanning, Guangxi, Peoples R China.; Feng, XM (corresponding author), Guangxi Key Lab Genom & Personalized Med, Nanning, Guangxi, Peoples R China.; Feng, XM (corresponding author), Guangxi Collaborat Innovat Ctr Genom & Personaliz, Nanning, Guangxi, Peoples R China.; Feng, XM (corresponding author), Guangxi Med Univ, Sch Publ Hlth, Dept Occupat Hlth & Environm Hlth, Nanning, Guangxi, Peoples R China.
EM fengxiuming@stu.gxmu.edu.cn; lilongman@stu.gxmu.edu.cn;
   luluhuang@gxmu.edu.cn; zhanghaiying@gxmu.edu.cn; zengnanmo@hotmail.com;
   yangx@gxmu.edu.cn
RI Feng, Xiuming/GSN-4262-2022; Yang, Xiaobo/AAD-6333-2019
OI mo, zengnan/0000-0002-3047-3138
FU Guangxi Natural Science Fund for Innovation Research Team
   [2017GXNSFGA198003, 2013GXNSFFA019002]; Program for New Century
   Excellent Talents in University [NCET-12-0653]; Guangxi key Laboratory
   for Genomic and Personalized Medicine [19-050-22, 20-065-33]
FX This work was supported by the Guangxi Natural Science Fund for
   Innovation Research Team [grant numbers 2017GXNSFGA198003,
   2013GXNSFFA019002]; the Program for New Century Excellent Talents in
   University [grant number NCET-12-0653]; and the Guangxi key Laboratory
   for Genomic and Personalized Medicine [grant numbers 19-050-22,
   20-065-33].
CR Akl EA, 2012, BMJ-BRIT MED J, V344, DOI 10.1136/bmj.e2809
   Al-Daghri NM, 2013, NUTRIENTS, V5, P4587, DOI 10.3390/nu5114587
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Andreadis EA, 2007, AM J HYPERTENS, V20, P558, DOI 10.1016/j.amjhyper.2006.12.001
   Bai JL, 2015, SCI REP-UK, V5, DOI 10.1038/srep15606
   Bulka CM, 2019, ENVIRON RES, V168, P397, DOI 10.1016/j.envres.2018.10.022
   Byrne C, 2013, J MAMMARY GLAND BIOL, V18, P63, DOI 10.1007/s10911-013-9273-9
   Chen K, 2012, UROLOGY, V80, P1287, DOI 10.1016/j.urology.2012.08.028
   Dai LZ, 2016, ENVIRON HEALTH PERSP, V124, P120, DOI 10.1289/ehp.1409021
   De Azevedo SV, 2013, CLIN BIOCHEM, V46, P123, DOI 10.1016/j.clinbiochem.2012.09.020
   Eom SY, 2014, INT ARCH OCC ENV HEA, V87, P501, DOI 10.1007/s00420-013-0891-8
   Forns J, 2016, ENVIRON RES, V151, P91, DOI 10.1016/j.envres.2016.07.014
   Freitas EPS, 2017, NUTRIENTS, V9, DOI 10.3390/nu9020175
   Freitas-Lima LC, 2018, TOXICOL LETT, V299, P21, DOI 10.1016/j.toxlet.2018.08.018
   Ge XT, 2018, J TRACE ELEM MED BIO, V45, P41, DOI 10.1016/j.jtemb.2017.09.016
   Ghasemi A, 2010, BIOL TRACE ELEM RES, V136, P18, DOI 10.1007/s12011-009-8522-7
   GREGER JL, 1981, FOOD COSMET TOXICOL, V19, P163, DOI 10.1016/0015-6264(81)90352-7
   Grimes DA, 2002, LANCET, V359, P341, DOI 10.1016/S0140-6736(02)07500-1
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Guo XL, 2019, ENVIRON POLLUT, V248, P66, DOI 10.1016/j.envpol.2019.02.015
   Gupta A, 2010, BIOSCI TRENDS, V4, P204
   Hildrum B, 2009, DIABETOLOGIA, V52, P583, DOI 10.1007/s00125-009-1271-5
   JOHNSON MA, 1982, AM J CLIN NUTR, V35, P1332, DOI 10.1093/ajcn/35.6.1332
   Jomova K, 2011, TOXICOLOGY, V283, P65, DOI 10.1016/j.tox.2011.03.001
   Kozlowski H, 2014, CURR MED CHEM, V21, P3721, DOI 10.2174/0929867321666140716093838
   Kurl S, 2016, INT J CARDIOL, V203, P792, DOI 10.1016/j.ijcard.2015.10.218
   Laohaudomchok W, 2011, J OCCUP ENVIRON MED, V53, P506, DOI 10.1097/JOM.0b013e31821854da
   Lee MC, 2019, ENVIRON SCI TECHNOL, V53, P7830, DOI 10.1021/acs.est.9b01359
   Li LM, 2020, SCI TOTAL ENVIRON, V720, DOI 10.1016/j.scitotenv.2020.137655
   Liu B, 2016, ENVIRON POLLUT, V210, P1, DOI 10.1016/j.envpol.2015.11.046
   Marott SCW, 2016, J CLIN ENDOCR METAB, V101, P3212, DOI 10.1210/jc.2015-3777
   Miao X, 2013, FRONT MED-PRC, V7, P31, DOI 10.1007/s11684-013-0251-9
   Noor N, 2018, ENVIRON INT, V121, P349, DOI 10.1016/j.envint.2018.08.029
   Pereira CLV, 2019, ENVIRON POLLUT, V247, P371, DOI 10.1016/j.envpol.2019.01.053
   Rhee SY, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-9
   Rotter I, 2015, INT J ENV RES PUB HE, V12, P3944, DOI 10.3390/ijerph120403944
   Satia JA, 2006, ANN EPIDEMIOL, V16, P53, DOI 10.1016/j.annepidem.2005.02.011
   Skalny Andrey A, 2015, Interdiscip Toxicol, V8, P131, DOI 10.1515/intox-2015-0020
   Stossi F, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0224405
   Tan AH, 2011, METABOLISM, V60, P1186, DOI 10.1016/j.metabol.2011.01.002
   Waalkes MP, 2000, TOXICOL SCI, V56, P255, DOI 10.1093/toxsci/56.2.255
   Williams M., 2012, TOXICOLOGICAL PROFIL
   Wu XY, 2016, ENVIRON SCI POLLUT R, V23, P8244, DOI 10.1007/s11356-016-6333-x
   Xing Y, 2018, J DIABETES, V10, P232, DOI 10.1111/1753-0407.12578
   Xu J, 2019, TOXICOLOGY, V425, DOI 10.1016/j.tox.2019.152242
   Yary T, 2017, NUTRITION, V37, P43, DOI 10.1016/j.nut.2016.09.004
   Yu YH, 2012, NUTR RES, V32, P71, DOI 10.1016/j.nutres.2011.12.004
   Yuan ZP, 2016, ANN NUTR METAB, V69, P125, DOI 10.1159/000450761
NR 48
TC 13
Z9 14
U1 0
U2 23
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD JUL
PY 2021
VL 199
IS 7
BP 2444
EP 2455
DI 10.1007/s12011-020-02371-w
EA OCT 2020
PG 12
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA SU8CK
UT WOS:000574802900001
PM 33009983
DA 2025-06-11
ER

PT J
AU Palomäki, A
   Pohjantähti-Maaroos, H
   Wallenius, M
   Kankkunen, P
   Aro, H
   Husgafvel, S
   Pihlava, JM
   Oksanen, K
AF Palomaki, Ari
   Pohjantahti-Maaroos, Hanna
   Wallenius, Marja
   Kankkunen, Paivi
   Aro, Heikki
   Husgafvel, Sari
   Pihlava, Juha-Matti
   Oksanen, Kalevi
TI Effects of dietary cold-pressed turnip rapeseed oil and butter on serum
   lipids, oxidized LDL and arterial elasticity in men with metabolic
   syndrome
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; POSTPRANDIAL OXIDATIVE
   STRESS; MEDITERRANEAN DIET; MYOCARDIAL-INFARCTION; RISK-FACTORS;
   FATTY-ACIDS; HEALTHY; GLUCOSE; SUSCEPTIBILITY
AB Background: Rapeseed oil is the principal dietary source of monounsaturated and n-3 polyunsaturated fatty acids in the Northern Europe. However, the effect of rapeseed oil on the markers of subclinical atherosclerosis is not known. The purpose of this study was to compare the effects of dietary intake of cold-pressed turnip rapeseed oil (CPTRO) and butter on serum lipids, oxidized LDL and arterial elasticity in men with metabolic syndrome.
   Methods: Thirty-seven men with metabolic syndrome completed an open and balanced crossover study. Treatment periods lasted for 6 to 8 weeks and they were separated from each other with an eight-week washout period. Subjects maintained their normal dietary habits and physical activity without major variations. The daily fat adjunct consisted either of 37.5 grams of butter or 35 mL of Virgino(R) CPTRO. Participants were asked to spread butter on bread on the butter period and to drink CPTRO on the oil period. The fat adjunct was used as such without heating or frying.
   Results: Compared to butter, administration of CPTRO was followed by a reduction of total cholesterol by 8% (p < 0.001) and LDL cholesterol by 11% (p < 0.001). The level of oxidized LDL was 16% lower after oil period (p = 0.024). Minimal differences in arterial elasticity were not statistically significant.
   Conclusion: Cold-pressed turnip rapeseed oil had favourable effects on circulating LDL cholesterol and oxidized LDL, which may be important in the management of patients at high cardiovascular risk.
C1 [Palomaki, Ari; Pohjantahti-Maaroos, Hanna; Wallenius, Marja; Kankkunen, Paivi; Husgafvel, Sari; Oksanen, Kalevi] Kanta Hame Cent Hosp, FI-13530 Hameenlinna, Finland.
   [Palomaki, Ari; Pohjantahti-Maaroos, Hanna; Wallenius, Marja] Linnan Klin, FI-13100 Hameenlinna, Finland.
   [Pohjantahti-Maaroos, Hanna] Kuopio Univ Hosp, Ctr Heart, FI-70211 Kuopio, Finland.
   [Wallenius, Marja] Mehilainen, FI-13100 Hameenlinna, Finland.
   [Kankkunen, Paivi] Finnish Inst Occupat Hlth, FI-00250 Helsinki, Finland.
   [Aro, Heikki; Pihlava, Juha-Matti] MTT Agrifood Res Finland, FI-31600 Jokioinen, Finland.
   [Aro, Heikki] Finnish Funding Agcy Technol & Innovat, FI-00101 Helsinki, Finland.
C3 Kuopio University Hospital; University of Eastern Finland; University of
   Eastern Finland Hospital; Finnish Institute of Occupational Health;
   Natural Resources Institute Finland (Luke); Finnish Funding Agency for
   Technology & Innovation (TEKES)
RP Pohjantähti-Maaroos, H (corresponding author), Kanta Hame Cent Hosp, Ahvenistontie 20, FI-13530 Hameenlinna, Finland.
EM hanna.pohjantahti-maaroos@kuh.fi
OI Palomaki, Ari/0000-0001-9759-4332; Pihlava,
   Juha-Matti/0000-0002-2404-6789
FU Ministry of Health and Social Welfare in Finland through Kanta-Hame
   Central Hospital; Finnish Cultural Foundation; Kankaisten Oljykasvit
   Ltd; Hilkka and Vaino Kiltti Foundation
FX This study was supported by grants from the Ministry of Health and
   Social Welfare in Finland through the Medical Research Fund of
   Kanta-Hame Central Hospital, the Hame Regional Fund under the auspices
   of the Finnish Cultural Foundation, Kankaisten Oljykasvit Ltd, and
   Hilkka and Vaino Kiltti Foundation. None of them had a role in data
   collection, analysis of the results, or preparation of the manuscript.
CR Anderson BM, 2009, LIPIDS HEALTH DIS, V8, DOI 10.1186/1476-511X-8-33
   Moreno JA, 2008, BRIT J NUTR, V100, P569, DOI 10.1017/S0007114508911508
   Araujo MC, 2010, J AM DIET ASSOC, V110, P1170, DOI 10.1016/j.jada.2010.05.008
   Bloomer RJ, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-79
   Brehm BJ, 2009, DIABETES CARE, V32, P215, DOI 10.2337/dc08-0687
   Cicerale S, 2010, INT J MOL SCI, V11, P458, DOI 10.3390/ijms11020458
   Cicero AFG, 2008, J AM COLL NUTR, V27, P314, DOI 10.1080/07315724.2008.10719705
   COHN JN, 1995, HYPERTENSION, V26, P503, DOI 10.1161/01.HYP.26.3.503
   Cortés B, 2006, J AM COLL CARDIOL, V48, P1666, DOI 10.1016/j.jacc.2006.06.057
   de Lorgeril M, 1999, CIRCULATION, V99, P779, DOI 10.1161/01.CIR.99.6.779
   DEGRAAF J, 1991, ARTERIOSCLER THROMB, V11, P298, DOI 10.1161/01.ATV.11.2.298
   Egert S, 2010, EUR J NUTR
   Fitó M, 2007, ARCH INTERN MED, V167, P1195, DOI 10.1001/archinte.167.11.1195
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Gulesserian T, 2002, J AM COLL NUTR, V21, P103, DOI 10.1080/07315724.2002.10719201
   Haffner SM, 1998, NEW ENGL J MED, V339, P229, DOI 10.1056/NEJM199807233390404
   Holvoet P, 1998, CIRCULATION, V98, P1487, DOI 10.1161/01.CIR.98.15.1487
   Holvoet P, 2001, ARTERIOSCL THROM VAS, V21, P844, DOI 10.1161/01.ATV.21.5.844
   Hulthe J, 2002, ARTERIOSCL THROM VAS, V22, P1162, DOI 10.1161/01.ATV.0000021150.63480.CD
   Kotani K, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-103
   Kratz M, 2002, EUR J CLIN NUTR, V56, P72, DOI 10.1038/sj.ejcn.1601288
   Kratz M, 2009, NUTR METAB, V6, DOI 10.1186/1743-7075-6-24
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Laurent S, 2006, EUR HEART J, V27, P2588, DOI 10.1093/eurheartj/ehl254
   LEAF A, 1990, CIRCULATION, V82, P624, DOI 10.1161/01.CIR.82.2.624
   Leite JO, 2010, ATHEROSCLEROSIS, V209, P442, DOI 10.1016/j.atherosclerosis.2009.10.005
   Leong XF, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-66
   Marchioli R, 2002, CIRCULATION, V105, P1897, DOI 10.1161/01.CIR.0000014682.14181.F2
   Mattila P, 2005, J AGR FOOD CHEM, V53, P8290, DOI 10.1021/jf051437z
   MCVEIGH GE, 1994, ARTERIOSCLER THROMB, V14, P1425, DOI 10.1161/01.ATV.14.9.1425
   Meisinger C, 2005, CIRCULATION, V112, P651, DOI 10.1161/CIRCULATIONAHA.104.529297
   Nathan DM, 2008, DIABETES CARE, V31, P1473, DOI 10.2337/dc08-0545
   Perez-Martinez P, 2010, CLIN SCI, V119, P251, DOI 10.1042/CS20100015
   Pohjantähti-Maaroos H, 2010, CARDIOVASC DIABETOL, V9, DOI 10.1186/1475-2840-9-41
   Ros E, 2004, CIRCULATION, V109, P1609, DOI 10.1161/01.CIR.0000124477.91474.FF
   Perona JS, 2009, J AGR FOOD CHEM, V57, P11427, DOI 10.1021/jf902321x
   Sattar N, 2003, CIRCULATION, V108, P414, DOI 10.1161/01.CIR.0000080897.52664.94
   Schwab U, 1998, EUR J CLIN NUTR, V52, P452, DOI 10.1038/sj.ejcn.1600587
   SEPPANENLAAKSO T, 1993, ANN NUTR METAB, V37, P161, DOI 10.1159/000177765
   Sigurdardottir V, 2002, J INTERN MED, V252, P440, DOI 10.1046/j.1365-2796.2002.01054.x
   Srivastava S, 2010, BR J NUTR
   Stocker R, 2004, PHYSIOL REV, V84, P1381, DOI 10.1152/physrev.00047.2003
   Tanigawa H, 2006, ATHEROSCLEROSIS, V188, P245, DOI 10.1016/j.atherosclerosis.2005.10.046
   Trichopoulou A, 2003, NEW ENGL J MED, V348, P2599, DOI 10.1056/NEJMoa025039
   VALSTA LM, 1992, ARTERIOSCLER THROMB, V12, P50, DOI 10.1161/01.ATV.12.1.50
   Vanhala M J, 1997, J Cardiovasc Risk, V4, P291, DOI 10.1097/00043798-199708000-00010
   Vermunt S, 2001, BR J NUTR, V85, P249
   Volek JS, 2009, LIPIDS, V44, P297, DOI 10.1007/s11745-008-3274-2
   Vuorela S, 2003, EUR FOOD RES TECHNOL, V217, P517, DOI 10.1007/s00217-003-0811-3
NR 49
TC 23
Z9 25
U1 0
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD DEC 1
PY 2010
VL 9
AR 137
DI 10.1186/1476-511X-9-137
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 703VW
UT WOS:000286010400001
PM 21122147
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Thauerer, B
   Tóth, AO
   Salzer, A
   Steinecker-Frohnwieser, B
AF Thauerer, Bettina
   Toth, Anna Odrovicsne
   Salzer, Andreas
   Steinecker-Frohnwieser, Bibiane
TI Success of an Inpatient Rehabilitation Program in Subjects with Type 2
   Diabetes Mellitus with or Without Metabolic Syndrome
SO BIOMOLECULES
LA English
DT Article
DE type 2 diabetes mellitus (T2DM); metabolic syndrome (MetS); advanced
   glycation end products (AGEs); soluble receptor for AGE (sRAGE); lipid
   metabolism; oxidative stress; prediction model; rehabilitation outcome
ID SERUM URIC-ACID; GLYCATION END-PRODUCTS; DISEASE; MEN
AB Introduction: Type 2 diabetes mellitus (T2DM) comprises heterogeneous disorders, which have an increase in blood glucose concentrations in common. Metabolic syndrome (MetS) describes the simultaneous occurrence of several clinical symptoms that increase the risk of cardiovascular disease and T2DM, although T2DM itself is also considered a risk factor for developing MetS. Objective: This study aimed to identify parameters related to rehabilitation success and relevant to MetS in T2DM patients. Methods: T2DM patients were divided into two subgroups based on the NHLBI/AHA and IDF guidelines for characterizing MetS. Serum samples were analyzed for T2DM-specific parameters, lipid metabolism, oxidative processes, AGE activity (AAct), and uric acid to HDL ratio (UHR) at admission and discharge after a 3-week inpatient rehabilitation stay. Logistic regression and before-after comparisons were performed showing the importance of multidisciplinary rehabilitation. Results: Among eighty-six patients, 59.3% had MetS. Significant differences between subgroups were found in fasting glucose (FBS), hemoglobin A1c (HbA1c), high-density lipoprotein cholesterol (HDL), triglycerides (TGLs), soluble receptor for AGE (sRAGE), UHR, and AAct. Rehabilitation-induced changes in disease-related parameters were influenced by the presence of MetS. The predictive capacity from all parameters together could be reduced within the three weeks. Conclusion: Rehabilitative measures have a major influence on MetS-relevant factors and can change the course of the disease in patients with T2DM. Identifying these factors can be of great importance for future diagnoses and treatments of T2DM and MetS.
C1 [Thauerer, Bettina; Toth, Anna Odrovicsne; Steinecker-Frohnwieser, Bibiane] Ludwig Boltzmann Inst Arthrit & Rehabil, A-5760 Saalfelden, Austria.
   [Salzer, Andreas] Rehabil Ctr Saalfelden Pens Insurance Inst, A-5760 Saalfelden, Austria.
   [Steinecker-Frohnwieser, Bibiane] Ludwig Boltzmann Inst Arthrit & Rehabil, A-8962 Grobming, Austria.
RP Thauerer, B; Steinecker-Frohnwieser, B (corresponding author), Ludwig Boltzmann Inst Arthrit & Rehabil, A-5760 Saalfelden, Austria.; Steinecker-Frohnwieser, B (corresponding author), Ludwig Boltzmann Inst Arthrit & Rehabil, A-8962 Grobming, Austria.
EM bettina.thauerer@ar.lbg.ac.at; anna.odrovicsne-toth@ar.lbg.ac.at;
   andreas.salzer@pv.at; bibiane.steinecker-frohnwieser@ar.lbg.ac.at
FU Ludwig Boltzmann Institute for Arthritis and Rehabilitation
FX This research received no external funding. The APC was funded by the
   Ludwig Boltzmann Institute for Arthritis and Rehabilitation.
CR Aguilar-Salinas Carlos A, 2019, F1000Res, V8, DOI 10.12688/f1000research.17122.1
   Akhil M., 2021, JK Sci, V23, P94
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Almdal T, 2004, ARCH INTERN MED, V164, P1422, DOI 10.1001/archinte.164.13.1422
   Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
   Bazmandegan G, 2024, NUTR METAB CARDIOVAS, V34, P1014, DOI 10.1016/j.numecd.2023.12.022
   Bowden RG, 2022, FRONT MED-LAUSANNE, V9, DOI 10.3389/fmed.2022.1039230
   Cavero-Redondo I, 2019, J CLIN MED, V8, DOI 10.3390/jcm8122090
   Chehade JM, 2013, DRUGS, V73, P327, DOI 10.1007/s40265-013-0023-5
   El Ridi R, 2017, J ADV RES, V8, P487, DOI 10.1016/j.jare.2017.03.003
   Fonseca VA, 2009, DIABETES CARE, V32, P1, DOI [10.2337/dc09-S301, 10.2337/dc09-9033]
   Hudson BI, 2014, METABOLISM, V63, P1125, DOI 10.1016/j.metabol.2014.05.011
   James M, 2020, J DIABETES METAB DIS, V19, P437, DOI 10.1007/s40200-020-00523-2
   Khalid M, 2022, BIOMOLECULES, V12, DOI 10.3390/biom12040542
   Khan MAB, 2020, J EPIDEMIOL GLOB HEA, V10, P107, DOI 10.2991/jegh.k.191028.001
   Khil J, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-33743-6
   Kocak MZ, 2019, REV ASSOC MED BRAS, V65, P9, DOI 10.1590/1806-9282.65.1.9
   Kodama S, 2009, DIABETES CARE, V32, P1737, DOI 10.2337/dc09-0288
   Kurtkulagi O, 2021, ROM J INTERN MED, V59, P403, DOI 10.2478/rjim-2021-0023
   Li YQ, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1201132
   Magliano D J., 2021, IDF DIABETES ATLAS, V10th
   Nsiah Kwabena, 2015, Int J Appl Basic Med Res, V5, P133, DOI 10.4103/2229-516X.157170
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Odrovicsné-Tóth A, 2023, J CLIN MED, V12, DOI 10.3390/jcm12051735
   Orrico F, 2023, BIOMOLECULES, V13, DOI 10.3390/biom13081262
   Paredes S, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-48120-5
   Pieme Constant Anatole, 2017, BMC Res Notes, V10, P141, DOI 10.1186/s13104-017-2463-6
   Prasad K, 2014, INT J ANGIOL, V23, P11, DOI 10.1055/s-0033-1363423
   Regufe Virginia M G, 2020, Porto Biomed J, V5, pe101, DOI 10.1097/j.pbj.0000000000000101
   Rovira-Llopis S, 2013, ANTIOXID REDOX SIGN, V19, P1452, DOI 10.1089/ars.2013.5307
   Saito Y, 2021, J CARDIOL, V78, P51, DOI 10.1016/j.jjcc.2020.12.013
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Stern MP, 2004, DIABETES CARE, V27, P2676, DOI 10.2337/diacare.27.11.2676
   Thauerer B, 2022, OSTEOARTHR CARTILAGE, V30, pS393
   van Woudenbergh GJ, 2011, J NUTR METAB, V2011, DOI 10.1155/2011/623076
   Weinbrenner T, 2006, AM J CLIN NUTR, V83, P30
   Zhou MZ, 2024, PHARMACOL RES, V206, DOI 10.1016/j.phrs.2024.107282
NR 37
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD DEC
PY 2024
VL 14
IS 12
AR 1527
DI 10.3390/biom14121527
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA Q8F5V
UT WOS:001386968900001
PM 39766234
OA gold
DA 2025-06-11
ER

PT J
AU Farag, AGA
   Badr, EAE
   El-Shafey, AESS
   Elshaib, ME
AF Farag, Azza Gaber Antar
   Badr, Eman A. E.
   El-Shafey, Asmaa El-Shafey Soliman
   Elshaib, Mustafa Elsayed
TI Fatty acid-binding protein 4 circulating levels in non-segmental
   vitiligo
SO ANAIS BRASILEIROS DE DERMATOLOGIA
LA English
DT Article
DE Fatty acid-binding proteins; Metabolic syndrome; Vitiligo
ID METABOLIC SYNDROME; OXIDATIVE STRESS; BIOMARKER; FABP4; EXPRESSION
AB Background: Vitiligo is an acquired and progressive mucocutaneous disease resulting from the loss of active epidermal melanocytes. Metabolic syndrome (MetS) affects about 25% of the world's population and is linked to inflammatory skin diseases including vitiligo. Fatty Acid Binding Protein 4 (FABP4) is an intracellular lipid chaperone. FABP4 is closely associated with MetS.
   Objectives: To evaluate the serum level of FABP4 in vitiligo patients and its relation to MetS in the investigated cases.
   Methods: This case control study was conducted on 45 patients having non segmental vitiligo and 45 matched controls. Their lipid profile, blood glucose and serum FABP4 levels were measured.
   Results: There were significant elevations in FABP4 (p < 0.001), cholesterol (p < 0.001), triglycerides (p = 0.005), and glucose (fasting [p = 0.001] and 2 hours post prandial [p < 0.001]) levels in patients in comparison with controls. MetS was significantly more prevalent among vitiligo patients (p < 0.001) and associated with high FABP4 serum levels (p = 0.037). In vitiligo patients, there were significant positive correlations between FABP4 serum levels and triglycerides (p = 0.047), cholesterol (p = 0.001) and LDL (p = 0.001) levels and negative correlation regarding HDL level (p = 0.009). FABP4 level was a significantly good diagnostic test for early detection of vitiligo (p < 0.001).
   Study limitations: The small number of studied subjects.
   Conclusions: FABP4 may play an active role in the disease process of vitiligo that could be mediated through associated dyslipidemia and hyperglycemia. FABP4 may be a marker of vitiligo helping in its early diagnosis, but it does not appear to be useful for determining vitiligo severity, activity or associated MetS. (C) 2021 Sociedade Brasileira de Dermatologia. Published by Elsevier Espana, S.L.U.
C1 [Farag, Azza Gaber Antar] Menoufia Univ, Fac Med, Androl & STDs, Shebin Alkom, Egypt.
   [Badr, Eman A. E.] Menoufia Univ, Fac Med, Med Biochem & Mol Biol Dept, Shebin Alkom, Egypt.
   [El-Shafey, Asmaa El-Shafey Soliman] Minist Hlth, Gen Hosp, Dermatol, Shebin Alkom, Egypt.
   [Elshaib, Mustafa Elsayed] Menoufia Univ, Fac Med, Shebin Alkom, Egypt.
C3 Egyptian Knowledge Bank (EKB); Menofia University; Egyptian Knowledge
   Bank (EKB); Menofia University; Egyptian Knowledge Bank (EKB); Ministry
   of Health & Population - Egypt; Egyptian Knowledge Bank (EKB); Menofia
   University
RP Farag, AGA (corresponding author), Menoufia Univ, Fac Med, Androl & STDs, Shebin Alkom, Egypt.
EM azzagaber92@yahoo.com
RI badr, eman/AAA-6718-2021
CR Atas H, 2017, BALK MED J, V34, P219, DOI 10.4274/balkanmedj.2016.1005
   Baran A, 2017, LIPIDS, V52, P51, DOI 10.1007/s11745-016-4211-4
   Boniface K, 2019, EXP DERMATOL, V28, P656, DOI 10.1111/exd.13879
   Boniface K, 2018, CLIN REV ALLERG IMMU, V54, P52, DOI 10.1007/s12016-017-8622-7
   Boord JB, 2002, ARTERIOSCL THROM VAS, V22, P1686, DOI 10.1161/01.ATV.0000033090.81345.E6
   Furuhashi M, 2011, INT J INFLAMM, V2011, DOI 10.4061/2011/642612
   Furuhashi M, 2014, CLIN MED INSIGHTS-CA, V8, P23, DOI 10.4137/CMC.S17067
   Gamil MIA., 2019, Zagazig Univ Med J, V25, P326, DOI [10.21608/zumj.2019.30922, DOI 10.21608/ZUMJ.2019.30922]
   Hamzavi I, 2004, ARCH DERMATOL, V140, P677, DOI 10.1001/archderm.140.6.677
   Hansson GK, 2011, NAT IMMUNOL, V12, P204, DOI 10.1038/ni.2001
   Hotamisligil GS, 2015, NAT REV ENDOCRINOL, V11, P592, DOI 10.1038/nrendo.2015.122
   Hui XY, 2010, J BIOL CHEM, V285, P10273, DOI 10.1074/jbc.M109.097907
   Huling LB, 2012, J ORAL PATHOL MED, V41, P149, DOI 10.1111/j.1600-0714.2011.01102.x
   Ishimura S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0081318
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kim M, 2018, EXP DERMATOL, V27, P98, DOI 10.1111/exd.13443
   Kralisch S, 2013, DIABETOLOGIA, V56, P10, DOI 10.1007/s00125-012-2737-4
   Lee D, 2014, ONCOL REP, V31, P1116, DOI 10.3892/or.2014.2975
   Ma CM, 2017, PEDIATR NEONATOL, V58, P178, DOI 10.1016/j.pedneo.2016.03.008
   Makowski L, 2004, J NUTR, V134, p2464S, DOI 10.1093/jn/134.9.2464S
   Ning H, 2016, ACTA DIABETOL, V53, P891, DOI 10.1007/s00592-016-0867-8
   Pan YD, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01347
   Roberts GHL, 2020, PIGM CELL MELANOMA R, V33, P8, DOI 10.1111/pcmr.12848
   Rodrigues M, 2017, J AM ACAD DERMATOL, V77, P1, DOI 10.1016/j.jaad.2016.10.048
   Rodríguez-Calvo R, 2017, J ENDOCRINOL, V233, pR173, DOI 10.1530/JOE-17-0031
   Sabat R, 2019, SEMIN IMMUNOPATHOL, V41, P359, DOI 10.1007/s00281-019-00742-7
   Sabir AA, 2016, NIGER J CLIN PRACT, V19, P128, DOI 10.4103/1119-3077.173705
   Sinha PK, 2019, J EVOL MED DENT SCI-, V8, P2783, DOI 10.14260/jemds/2019/604
   Speeckaert R, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.568447
   Tanacan E, 2020, AN BRAS DERMATOL, V95, P165, DOI 10.1016/j.abd.2019.07.006
   Terra XM, 2011, EUR J ENDOCRINOL, V164, P539, DOI 10.1530/EJE-10-1195
   Wan J, 2017, INT J BIOL SCI, V13, P391, DOI 10.7150/ijbs.17318
   Wang P, 2016, J DERMATOL SCI, V84, P40, DOI 10.1016/j.jdermsci.2016.07.006
   Xie H, 2016, J DERMATOL SCI, V81, P3, DOI 10.1016/j.jdermsci.2015.09.003
   Zhang CF, 2018, BIOMARK MED, V12, P107, DOI 10.2217/bmm-2017-0207
NR 35
TC 6
Z9 6
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0365-0596
EI 1806-4841
J9 AN BRAS DERMATOL
JI An. Brasil. Dermatol.
PD JAN-FEB
PY 2022
VL 97
IS 1
BP 28
EP 36
DI 10.1016/j.abd.2021.04.014
EA JAN 2022
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA YP6FI
UT WOS:000748717000004
PM 34839983
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Abood, SJ
   Abdulsahib, WK
   Hussain, SA
   Ismail, SH
AF Abood, Sattar J.
   Abdulsahib, Waleed K.
   Hussain, Saad A.
   Ismail, Sajida H.
TI Melatonin Potentiates the Therapeutic Effects of Metformin in Women with
   Metabolic Syndrome
SO SCIENTIA PHARMACEUTICA
LA English
DT Article
DE melatonin; metformin; metabolic syndrome
ID INSULIN; LEPTIN; ACTIVATION; ADIPOSITY; PROTEIN; STRESS; WEIGHT
AB Objective: This study evaluated the effect of melatonin on the response of patients suffering from metabolic syndrome (MEBS) treated with metformin. Design: This study used two-armed groups in a double-blind, randomized controlled clinical trial. Materials and Methods: A randomized double-blind placebo-controlled study was carried out on female patients diagnosed as having MEBS, according to the International Diabetes Federation (IDF) diagnosing criteria of MEBS (2005), from the outpatient clinic in Al-Zahraa Teaching Hospital/Kut, Iraq. They were diagnosed utilizing laboratory and clinical investigations, then randomized into two groups. The first group (group A) was treated with metformin (500 mg) twice daily, in addition to a placebo formula once daily at bedtime for three months. The second group (group B) was treated with metformin (500 mg) twice daily after meals, in addition to melatonin (10 mg) once daily at bedtime for three months. Results: The treatment of patients with MEBS using metformin-melatonin showed an improvement in most MEBS components such as fasting serum glucose (FSG), lipid profile, and body mass index (BMI), in addition to a reduction in insulin resistance and hyperinsulinemia. Simultaneously, there were increments in serum uric acid (UA), leptin, prolactin (PRL), and estradiol levels, while serum progesterone level decreased. Furthermore, patients treated with metformin-placebo showed less improvement in the studied parameters compared to that produced due to the inclusion of melatonin in the treatment protocol. Conclusion: Melatonin improves the effect of metformin on several components of MEBS such as FSG, lipid profile, and BMI, in addition to insulin resistance and hyperinsulinemia, compared to metformin alone.
C1 [Abood, Sattar J.; Abdulsahib, Waleed K.] Al Farahidi Univ, Coll Pharm, Dept Pharmacol & Toxicol, Baghdad 10070, Iraq.
   [Hussain, Saad A.] Al Rafidain Univ Coll, Fac Pharm, Baghdad 10064, Iraq.
   [Ismail, Sajida H.] Univ Baghdad, Coll Pharm, Baghdad 10047, Iraq.
C3 Al-Farahidi University; University of Baghdad
RP Abdulsahib, WK (corresponding author), Al Farahidi Univ, Coll Pharm, Dept Pharmacol & Toxicol, Baghdad 10070, Iraq.
EM lokmas14@gmail.com; waleed.abdelsahib@alfarahidiuc.edu.iq;
   saad_alzaidi@yahoo.com; sajidahusain63@yahoo.com
RI Hussain, Saad/L-1237-2017; Al-Hussein, Sattar/ABA-6007-2020; ismael,
   sajida/GNP-0479-2022; Abdulsahib, Waleed K/AAY-9263-2020
OI Al- Hussein, Dr.Sattar/0000-0002-7824-9549; Abdulsahib, Waleed
   K/0000-0002-8851-5783; hussein, sajidah/0000-0001-8490-8136
CR Ali H, 2020, AGING DIS, V11, P31, DOI 10.14336/AD.2019.0403
   Alonso-Vale MIC, 2005, AM J PHYSIOL-ENDOC M, V288, pE805, DOI 10.1152/ajpendo.00478.2004
   Anhê GF, 2004, J NEUROCHEM, V90, P559, DOI 10.1111/j.1471-4159.2004.02514.x
   Banerjee A., 2020, MELATONIN RES, V3, P1, DOI [10.32794/mr11250045, DOI 10.32794/MR11250045]
   Barzilai N, 1997, J CLIN INVEST, V100, P3105, DOI 10.1172/JCI119865
   Boga JA, 2019, J PINEAL RES, V66, DOI 10.1111/jpi.12534
   Chew GT, 2006, MED J AUSTRALIA, V185, P445, DOI 10.5694/j.1326-5377.2006.tb00644.x
   de Oliveira AC, 2018, LIFE SCI, V199, P158, DOI 10.1016/j.lfs.2018.02.040
   Rodrigues MED, 2019, ALZHEIMERS RES THER, V12, DOI 10.1186/s13195-019-0546-4
   Després JP, 2020, P NUTR SOC, V79, P4, DOI 10.1017/S0029665119001010
   Dutta S, 2018, FOOD CHEM TOXICOL, V118, P303, DOI 10.1016/j.fct.2018.05.032
   Gupta G, 2020, ADV BIOCHEM HEALTH D, V19, P81, DOI 10.1007/978-3-030-35358-2_5
   Ha E, 2006, J PINEAL RES, V41, P67, DOI 10.1111/j.1600-079X.2006.00334.x
   Harborne LR, 2005, J CLIN ENDOCR METAB, V90, P4593, DOI 10.1210/jc.2004-2283
   Jeong J, 2019, J KOREAN MED SCI, V34, DOI 10.3346/jkms.2019.34.e307
   Kadhim HM, 2006, J PINEAL RES, V41, P189, DOI 10.1111/j.1600-079X.2006.00353.x
   Karamitri A, 2018, SCI SIGNAL, V11, DOI 10.1126/scisignal.aan6622
   Kok P, 2004, J CLIN ENDOCR METAB, V89, P4445, DOI 10.1210/jc.2003-032184
   La SA, 2016, BIOL TRACE ELEM RES, V170, P33, DOI 10.1007/s12011-015-0446-9
   Laaksonen DE, 2004, DIABETOLOGIA, V47, P1403, DOI 10.1007/s00125-004-1472-x
   Li YL, 2018, INT J MOL MED, V41, P955, DOI 10.3892/ijmm.2017.3305
   Lin JD, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-42442-0
   Maqbool M., 2019, J. Drug Deliv. Ther, V9, P433, DOI [DOI 10.22270/JDDT.V9I1-S.2275, 10.22270/jddt.v9i1-s.2275]
   Matthaei S, 2000, ENDOCR REV, V21, P585, DOI 10.1210/er.21.6.585
   McCaffery JM, 2006, DIABETES CARE, V29, P1719, DOI 10.2337/dc06-0583
   Minguini IP, 2019, REV ASSOC MED BRAS, V65, P1122, DOI 10.1590/1806-9282.65.8.1122
   Muldoon MF, 2004, J CLIN ENDOCR METAB, V89, P266, DOI 10.1210/jc.2003-031295
   Ortega-González C, 2005, J ENDOCRINOL, V184, P233, DOI 10.1677/joe.1.05844
   Ou TH, 2019, NUTRIENTS, V11, DOI 10.3390/nu11040748
   Owino S, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00488
   Serlie MJ, 2020, HBK BEHAV NEUROSCI, V31, P893, DOI 10.1016/B978-0-444-64125-0.00045-1
   Vaajanen A, 2011, BASIC CLIN PHARMACOL, V109, P217, DOI 10.1111/j.1742-7843.2011.00729.x
   Wolden-Hanson T, 2000, ENDOCRINOLOGY, V141, P487, DOI 10.1210/en.141.2.487
   Xiao LF, 2019, REPROD BIOL ENDOCRIN, V17, DOI 10.1186/s12958-018-0446-7
   Yuan Y, 2019, HORM METAB RES, V51, P367, DOI 10.1055/a-0882-7382
   Zaki NFW, 2020, NAT SCI SLEEP, V12, P135, DOI 10.2147/NSS.S206768
   Zhou CJ, 2020, OBES SURG, V30, P319, DOI 10.1007/s11695-019-04163-1
NR 37
TC 11
Z9 11
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-0532
J9 SCI PHARM
JI Sci. Pharm.
PY 2020
VL 88
IS 2
AR 28
DI 10.3390/scipharm88020028
PG 14
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA MN9KO
UT WOS:000551158800002
OA gold
DA 2025-06-11
ER

PT J
AU Li, P
   He, L
   Bin Chen, Z
   Luan, QX
AF Li, Peng
   He, Lu
   Bin Chen, Zhi
   Luan, Qing Xian
TI Biomarkers in Metabolic Syndrome Patients with Chronic Periodontitis
SO CHINESE JOURNAL OF DENTAL RESEARCH
LA English
DT Article
DE cytokines; inflammation; metabolic syndrome; periodontitis
ID C-REACTIVE PROTEIN; OXIDATIVE STRESS; MARKERS; SERUM; ASSOCIATION;
   CYTOKINES; DISEASE; HEALTH
AB Objectives: To investigate whether the levels of serum C-reactive protein (CRP), salivary interleukin (IL)-6 and IL-1 beta in metabolic syndrome (MS) patients can be potential monitors for inflammation in MS patients with severe periodontitis.
   Methods: A total of 114 MS patients and 49 systemically healthy subjects were enrolled. CRP in serum and IL-1 beta and IL-6 in non-stimulated whole saliva were collected from these patients and subjects and analysed by enzyme-linked immunosorbent assay (ELISA). Dental examinations were performed and the participants completed a questionnaire.
   Results: The serum CRP level of MS patients was higher than that of systemically healthy subjects, and increased as the number of components increased (P < 0.05). No difference was observed in the salivary level of IL-6 and IL-1 beta between MS patients and controls or between MS patients with different components. The level of salivary IL-6 in MS patients with moderate/severe periodontitis was significantly higher than in MS patients with good periodontal health/mild periodontitis (P < 0.05). After adjustment for age, sex and smoking habits, multivariate analysis showed that the corresponding odds ratio (OR) for MS combined with moderate/severe periodontitis was 1.21 (95% confidence interval [CI] 1.04-1.39, P = 0.012) for subjects with high serum CRP and salivary IL-6 and IL-1 beta were not risk indicators for MS combined with moderate/severe periodontitis.
   Conclusions: MS patients might be burdened by high levels of serum CRP. Serum CRP could be a potentially valuable biomarker to detect inflammation in MS patients with severe periodontal disease.
C1 [Li, Peng] Peking Univ, Dent Ctr 2, Natl Engn Lab Digital & Mat Technol Stomatol, Beijing Key Lab Digital Stomatol,Sch & Hosp Stoma, Beijing, Peoples R China.
   [He, Lu; Bin Chen, Zhi; Luan, Qing Xian] Peking Univ, Dept Periodontol, Sch & Hosp Stomatol, Beijing, Peoples R China.
C3 Peking University; Peking University
RP Li, P (corresponding author), Peking Univ, Dent Ctr 2, Sch & Hosp Stomatol, B5 Anli Garden,66 Anli Rd, Beijing 100101, Peoples R China.
EM kqlipeng05420533@sina.com
RI peng, li/GQO-9368-2022
FU Chinese National Key Science and Technology Project from the 'Eleventh
   Five-Year Plan' [2007BAI18B02]; National Nature Science Foundation of
   China [81200784]
FX This investigation was supported by the Chinese National Key Science and
   Technology Project from the 'Eleventh Five-Year Plan' (2007BAI18B02) and
   funded in part by the National Nature Science Foundation of China (Grant
   number 81200784).
CR Abduljabbar T, 2016, CYTOKINE, V88, P51, DOI 10.1016/j.cyto.2016.08.017
   Arbes SJ, 1999, J DENT RES, V78, P1777, DOI 10.1177/00220345990780120301
   Azizi A, 2015, BIOMARKERS, V20, P306, DOI 10.3109/1354750X.2015.1068864
   Batool H, 2018, BIOMED RES INT, V2018, DOI 10.1155/2018/8531961
   Boras VV, 2006, J ORAL PATHOL MED, V35, P241, DOI 10.1111/j.1600-0714.2006.00404.x
   D'Aiuto F, 2008, J CLIN ENDOCR METAB, V93, P3989, DOI 10.1210/jc.2007-2522
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Feng Xiang-hui, 2010, Beijing Da Xue Xue Bao Yi Xue Ban, V42, P207
   Ford ES, 2003, ATHEROSCLEROSIS, V168, P351, DOI 10.1016/S0021-9150(03)00134-5
   FUJIHASHI K, 1993, J PERIODONTOL, V64, P400
   Hoseini Amineh, 2017, Electron Physician, V9, P5244, DOI 10.19082/5244
   Ide M, 2003, J CLIN PERIODONTOL, V30, P334, DOI 10.1034/j.1600-051X.2003.00282.x
   ISHIMI Y, 1990, J IMMUNOL, V145, P3297
   Lan Y, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0196012
   Li P, 2009, J PERIODONTOL, V80, P541, DOI 10.1902/jop.2009.080387
   Loos BG, 2000, J PERIODONTOL, V71, P1528, DOI 10.1902/jop.2000.71.10.1528
   MAZZA JE, 1981, J CLIN PERIODONTOL, V8, P203, DOI 10.1111/j.1600-051X.1981.tb02031.x
   MURRAH VA, 1985, J ORAL PATHOL MED, V14, P236, DOI 10.1111/j.1600-0714.1985.tb00487.x
   SILNESS J, 1964, Acta Odontol Scand, V22, P121, DOI 10.3109/00016356408993968
   Singer RE, 2015, J DENT RES, V94, P1698, DOI 10.1177/0022034515602693
   Thanakun S, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0148638
   Tobón-Arroyave SI, 2008, ARCH ORAL BIOL, V53, P346, DOI 10.1016/j.archoralbio.2007.11.005
   Torumtay G, 2016, J PERIODONTAL RES, V51, P489, DOI 10.1111/jre.12328
   Yamazaki K, 2005, J PERIODONTAL RES, V40, P53, DOI 10.1111/j.1600-0765.2004.00772.x
   Zhang YY, 2008, CYTOKINE, V41, P144, DOI 10.1016/j.cyto.2007.11.004
   Zimmet P, 2005, J ATHEROSCLER THROMB, V12, P295, DOI 10.5551/jat.12.295
NR 26
TC 3
Z9 3
U1 0
U2 6
PU QUINTESSENCE PUBLISHING CO INC
PI HANOVER PARK
PA 4350 CHANDLER DRIVE, HANOVER PARK, IL 60133 USA
SN 1462-6446
EI 1867-5646
J9 CHIN J DENT RES
JI Chin. J. Dent. Res.
PY 2020
VL 23
IS 3
BP 191
EP 197
DI 10.3290/j.cjdr.a45223
PG 7
WC Dentistry, Oral Surgery & Medicine
WE Emerging Sources Citation Index (ESCI)
SC Dentistry, Oral Surgery & Medicine
GA NX6LI
UT WOS:000575819900004
PM 32974619
DA 2025-06-11
ER

PT J
AU Gheita, TA
   Kenawy, SAB
   El Sisi, RW
   Gheita, HA
   Khalil, H
AF Gheita, Tamer Atef
   Kenawy, Sanaa Abdel Baky
   El Sisi, Rehab Wafik
   Gheita, Heba Atef
   Khalil, Hossam
TI Subclinical reduced G6PD activity in rheumatoid arthritis and Sjogren's
   Syndrome patients: Relation to clinical characteristics, disease
   activity and metabolic syndrome
SO MODERN RHEUMATOLOGY
LA English
DT Article
DE DAS28; G6PD activity; Metabolic syndrome; Rheumatoid arthritis;
   Sjogren's Syndrome
ID GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY; OXIDATIVE STRESS;
   CLASSIFICATION CRITERIA; GENETIC ABNORMALITIES; RISK; FREQUENCY
AB Objective. Glucose-6-phosphate dehydrogenase (G6PD) is an important site of metabolic control in the pentose phosphate pathway. The purpose of this study was to investigate the enzyme activity of G6PD in Rheumatoid Arthritis (RA) and Sjogren's Syndrome (SS) patients not known to be deficient in this enzyme. It was also within the scope of the aim to find the relation of G6PD to the presence of metabolic syndrome (MetS) in these patients.
   Methods. Erythrocyte G6PD activity was evaluated in 40 RA patients, 30 SS patients and in 30 age- and sex-matched control. The clinical characteristics, disease activity score (DAS28), SS disease activity (SSDAI) and damage (SSDDI) indices and presence of MetS of the included patients were analyzed in relation to the enzyme level.
   Results. The G6PD activity in RA patients (7.72 +/- 3.57 U/g Hb) was significantly reduced compared to that in the SS patients (11.55 +/- 3.14 U/g Hb) and control (13.23 +/- 3.34 U/g Hb) especially those with MetS (4.61 +/- 1.84 U/g Hb) (p < 0.001). There was a significant negative correlation of the G6PD activity with the disease duration and DAS28 (p < 0.001).
   Conclusion. The results of this study, suggest that G6PD not only does not protect against MetS in RA, but may even be considered a risk factor for the development of this disorder. The identification of regulatory tools for G6PD activity may prove promising for treating the associated metabolic disorders and chronic inflammation in RA.
C1 [Gheita, Tamer Atef] Cairo Univ, Fac Med, Dept Rheumatol, Giza 12613, Egypt.
   [Kenawy, Sanaa Abdel Baky] Cairo Univ, Fac Med, Dept Pharmacol, Giza 12613, Egypt.
   [El Sisi, Rehab Wafik] Cairo Univ, Fac Oral & Dent Med, Giza 12613, Egypt.
   [Gheita, Heba Atef] Atom Energy Authorizat, Dept Pharmacol, Cairo, Egypt.
   [Khalil, Hossam] Beni Sweif Univ, Fac Med, Dept Ophthalmol, Beni Sweif, Egypt.
C3 Egyptian Knowledge Bank (EKB); Cairo University; Egyptian Knowledge Bank
   (EKB); Cairo University; Egyptian Knowledge Bank (EKB); Cairo
   University; Egyptian Knowledge Bank (EKB); Egyptian Atomic Energy
   Authority (EAEA); Egyptian Knowledge Bank (EKB); Beni Suef University
RP Gheita, TA (corresponding author), Cairo Univ, Fac Med, Dept Rheumatol, POB 12611,Gamaa St, Giza 12613, Egypt.
EM gheitamer@hotmail.com
RI Gheita, Tamer/HHC-8095-2022
OI A Gheita, Tamer/0000-0002-1155-9729; Gheita, Heba/0000-0002-5782-2908
CR Aletaha D, 2010, ARTHRITIS RHEUM-US, V62, P2569, DOI 10.1002/art.27584
   Beutler E, 2002, BLOOD CELL MOL DIS, V28, P93, DOI 10.1006/bcmd.2002.0490
   Beutler E, 1971, RED CELL METABOLISM, P68, DOI DOI 10.7326/0003-4819-75-6-985_1
   BEUTLER E, 2001, WILLIAMS HEMATOLOGY, P527
   Carette C, 2011, DIABETES METAB, V37, P79, DOI 10.1016/j.diabet.2010.09.004
   Carter N, 2011, MALARIA J, V10, DOI 10.1186/1475-2875-10-241
   Cattaneo G, 1989, Pediatr Med Chir, V11, P219
   Chen CH, 2012, J MICROBIOL IMMUNOL
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Devi AMS, 2010, INDIAN J HEMATOL BLO, V26, P122, DOI 10.1007/s12288-010-0039-x
   Emamghorashi F, 2010, HEMATOLOGY, V15, P122, DOI 10.1179/102453310X12583347010179
   Evans JL, 2002, ENDOCR REV, V23, P599, DOI 10.1210/er.2001-0039
   Fanello CI, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0004031
   Fico A, 2004, CELL DEATH DIFFER, V11, P823, DOI 10.1038/sj.cdd.4401420
   Finkel T, 2000, NATURE, V408, P239, DOI 10.1038/35041687
   Gupte RS, 2011, ANTIOXID REDOX SIGN, V14, P543, DOI 10.1089/ars.2010.3207
   Hassan SZ, 2011, INT J RHEUM DIS, V14, P325, DOI 10.1111/j.1756-185X.2011.01630.x
   Ho HY, 2007, REDOX REP, V12, P109, DOI 10.1179/135100007X200209
   Ho Hung-Yao, 2005, Chang Gung Med J, V28, P606
   Jiang WY, 2012, BIOCHEM GENET, V50, P34, DOI 10.1007/s10528-011-9455-3
   Khurana V, 1998, J Assoc Acad Minor Phys, V9, P56
   Kim JW, 2005, TRENDS BIOCHEM SCI, V30, P142, DOI 10.1016/j.tibs.2005.01.005
   Leopold JA, 2003, ARTERIOSCL THROM VAS, V23, P411, DOI 10.1161/01.ATV.0000056744.26901.BA
   Meloni L, 2008, J INHERIT METAB DIS, V31, P412, DOI 10.1007/s10545-008-0704-5
   Moiz B, 2011, INT J LAB HEMATOL, V33, P570, DOI 10.1111/j.1751-553X.2011.01325.x
   Nahir A M, 1990, Aging (Milano), V2, P363
   OPPENHEIM A, 1993, HUM GENET, V91, P293
   Park J, 2006, DIABETES, V55, P2939, DOI 10.2337/db05-1570
   Peiretti E, 2010, INVEST OPHTH VIS SCI, V51, P2928, DOI 10.1167/iovs.09-4426
   Pinna A, 2008, INVEST OPHTH VIS SCI, V49, P1328, DOI 10.1167/iovs.07-1115
   Prchal Josef T, 2005, Hematology Am Soc Hematol Educ Program, P19, DOI 10.1182/asheducation-2005.1.19
   PREVOO MLL, 1995, ARTHRITIS RHEUM, V38, P44, DOI 10.1002/art.1780380107
   Sadler Jr JM, 2009, BMJ CASE REP
   Usanga EA, 2000, HUM HERED, V50, P158, DOI 10.1159/000022906
   Vitali C, 2002, ANN RHEUM DIS, V61, P554, DOI 10.1136/ard.61.6.554
   Vitali C, 2007, ARTHRITIS RHEUM-US, V56, P2223, DOI 10.1002/art.22658
   Wan GH, 2002, ENDOCRINE, V19, P191, DOI 10.1385/ENDO:19:2:191
   WHITE JM, 1986, J MED GENET, V23, P245, DOI 10.1136/jmg.23.3.245
   WHITE JM, 1993, J MED GENET, V30, P396, DOI 10.1136/jmg.30.5.396
   Zhang ZY, 2010, FASEB J, V24, P1497, DOI 10.1096/fj.09-136572
NR 40
TC 34
Z9 34
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1439-7595
EI 1439-7609
J9 MOD RHEUMATOL
JI Mod. Rheumatol.
PD JUL
PY 2014
VL 24
IS 4
BP 612
EP 617
DI 10.3109/14397595.2013.851639
PG 6
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA AK7VT
UT WOS:000338636500011
PM 24252052
DA 2025-06-11
ER

PT J
AU Younossi, ZM
AF Younossi, Z. M.
TI Review article: current management of non-alcoholic fatty liver disease
   and non-alcoholic steatohepatitis
SO ALIMENTARY PHARMACOLOGY & THERAPEUTICS
LA English
DT Review
ID CHRONIC HEPATITIS-C; VITAMIN-E TREATMENT; URSODEOXYCHOLIC ACID;
   CONTROLLED-TRIAL; UNITED-STATES; RISK-FACTORS; TRANSIENT ELASTOGRAPHY;
   OVERWEIGHT PATIENTS; METABOLIC SYNDROME; BARIATRIC SURGERY
AB Background
   Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome.
   Aim
   To assess the epidemiological impact and the current management of patients with NAFLD.
   Methods
   Published peer-reviewed literature and abstracts concerning NAFLD and non-alcoholic steatohepatitis (NASH) were reviewed. Articles specifically related to epidemiology, diagnosis and current treatment strategies for NAFLD and NASH are summarized.
   Results
   NAFLD is strongly associated with the epidemic of obesity and type-2 diabetes mellitus, and is estimated to affect about 20-30% of the population in the US. From the spectrum of NAFLD, only patients with biopsy-proven NASH (estimated prevalence in the US population is about 3-5%) have been convincingly shown to progress to cirrhosis, liver failure and hepatocellular carcinoma. The clinical manifestation of NAFLD is usually absent or subtle, with abnormal aminotransferases or incidental radiographic findings of fatty liver. The pathogenesis of NAFLD is attributed to a multi-hit process involving insulin resistance, oxidative stress, apoptotic pathways, and adipocytokines. In 2008, there is no established treatment for NAFLD. Weight loss and treatment for each component of metabolic syndrome. Nevertheless, a large number of agents are being considered in clinical trials of patients with NASH.
   Conclusions
   Awareness of the tremendous impact of NAFLD as an important cause of chronic liver disease is increasing along with a great deal of information about its pathogenesis. Future, well-designed clinical trials that target specific pathways involved in the pathogenesis of NASH are urgently needed.
C1 Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA USA.
C3 Inova Fairfax Hospital
RP Younossi, ZM (corresponding author), Inova Fairfax Hosp, Ctr Liver Dis, 3300 Gallows Rd, Falls Church, VA USA.
EM Zobair.younossi@inova.org
RI Younossi, Zobair M./JRY-9916-2023
CR Abdelmalek MF, 2001, AM J GASTROENTEROL, V96, P2711
   Adams LA, 2005, GASTROENTEROLOGY, V129, P113, DOI 10.1053/j.gastro.2005.04.014
   Adams LA, 2004, AM J GASTROENTEROL, V99, P2365, DOI 10.1111/j.1572-0241.2004.40064.x
   Al Knawy B, 2007, LIVER INT, V27, P1166, DOI 10.1111/j.1478-3231.2007.01592.x
   ANDERSEN T, 1991, J HEPATOL, V12, P224, DOI 10.1016/0168-8278(91)90942-5
   Angulo P, 2007, HEPATOLOGY, V45, P846, DOI 10.1002/hep.21496
   [Anonymous], FATTY LIVER DIS NASH
   BARANOVA A, 2006, ADIPOSE TISSUE ADIPO, P291
   Baranova A, 2008, HEPATOLOGY, V47, P373, DOI 10.1002/hep.22140
   Baranova Ancha, 2007, Clin Liver Dis, V11, P209, DOI 10.1016/j.cld.2007.02.003
   Basaranoglu M, 1999, J HEPATOL, V31, P384, DOI 10.1016/S0168-8278(99)80243-8
   Belfort R, 2006, NEW ENGL J MED, V355, P2297, DOI 10.1056/NEJMoa060326
   Bondini Silvia, 2007, Clin Liver Dis, V11, P17
   Brolin RE, 2002, JAMA-J AM MED ASSOC, V288, P2793, DOI 10.1001/jama.288.22.2793
   Browning JD, 2004, HEPATOLOGY, V40, P1387, DOI 10.1002/hep.20466
   Bugianesi E, 2005, AM J GASTROENTEROL, V100, P1082, DOI 10.1111/j.1572-0241.2005.41583.x
   CAIRNS SR, 1983, CLIN SCI, V65, P645, DOI 10.1042/cs0650645
   Caldwell SH, 2002, AM J GASTROENTEROL, V97, P1496, DOI 10.1016/S0002-9270(02)04151-5
   Calès P, 2005, HEPATOLOGY, V42, P1373, DOI 10.1002/hep.20935
   Chalasani N, 2005, HEPATOLOGY, V41, P690, DOI 10.1002/hep.20671
   CHARATCHAROENWI.C, ROLE RADIOLOGIC MODA
   Charatcharoenwitthaya P, 2007, LIVER INT, V27, P220, DOI 10.1111/j.1478-3231.2006.01404.x
   Clark JM, 2003, AM J GASTROENTEROL, V98, P960, DOI [10.1016/S0002-9270(03)00265-X, 10.1111/j.1572-0241.2003.07486.x]
   Collantes R, 2004, CLEV CLIN J MED, V71, P657, DOI 10.3949/ccjm.71.8.657
   Dan AA, 2007, ALIMENT PHARM THER, V26, P815, DOI 10.1111/j.1365-2036.2007.03426.x
   Daubioul CA, 2005, EUR J CLIN NUTR, V59, P723, DOI 10.1038/sj.ejcn.1602127
   Despres JP, 2005, NEW ENGL J MED, V353, P2121, DOI 10.1056/NEJMoa044537
   Dixon JB, 2004, HEPATOLOGY, V39, P1647, DOI 10.1002/hep.20251
   DOMINGUEZ EG, 2006, ALIMENT PHARM THER, V23, P1643
   Edmison John, 2007, Clin Liver Dis, V11, P75, DOI 10.1016/j.cld.2007.02.011
   Ekstedt M, 2006, HEPATOLOGY, V44, P865, DOI 10.1002/hep.21327
   Falck-Ytter Y, 2001, SEMIN LIVER DIS, V21, P17, DOI 10.1055/s-2001-12926
   Fishbein MH, 2006, J PEDIATR GASTR NUTR, V42, P83
   Foucher J, 2006, GUT, V55, P403, DOI 10.1136/gut.2005.069153
   Guha IN, 2008, HEPATOLOGY, V47, P455, DOI 10.1002/hep.21984
   Gulbahar O, 2000, GASTROENTEROLOGY, V118, pA1444, DOI 10.1016/S0016-5085(00)81671-6
   Harrison SA, 2003, AM J GASTROENTEROL, V98, P2485, DOI 10.1111/j.1572-0241.2003.08699.x
   Harrison SA, 2003, AM J GASTROENTEROL, V98, P926, DOI 10.1111/j.1572-0241.2003.07375.x
   Hasegawa T, 2001, ALIMENT PHARM THERAP, V15, P1667, DOI 10.1046/j.1365-2036.2001.01083.x
   Hatzitolios Apostolos, 2004, Indian J Gastroenterol, V23, P131
   Ioannou GN, 2006, AM J GASTROENTEROL, V101, P76, DOI 10.1111/j.1572-0241.2005.00341.x
   Kadayifci Abdurrahman, 2007, Clin Liver Dis, V11, P119, DOI 10.1016/j.cld.2007.02.001
   Kim JK, 2001, P NATL ACAD SCI USA, V98, P7522, DOI 10.1073/pnas.121164498
   Kim KM, 2007, J GASTROENTEROL, V42, P382, DOI 10.1007/s00535-007-2016-1
   Kiyici M, 2003, CAN J GASTROENTEROL, V17, P713, DOI 10.1155/2003/857869
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Kral JG, 2004, SURGERY, V135, P48, DOI 10.1016/j.surg.2003.10.003
   Kugelmas M, 2003, HEPATOLOGY, V38, P413, DOI 10.1053/jhep.2003.50316
   Laurin J, 1996, HEPATOLOGY, V23, P1464
   Lavine JE, 2000, J PEDIATR-US, V136, P734, DOI 10.1016/S0022-3476(00)05040-X
   Leclercq IA, 2000, J CLIN INVEST, V105, P1067, DOI 10.1172/JCI8814
   LEE RG, 1989, HUM PATHOL, V20, P594, DOI 10.1016/0046-8177(89)90249-9
   LEEVY CM, 1962, MEDICINE, V41, P249, DOI 10.1097/00005792-196209000-00003
   Lindor KD, 2004, HEPATOLOGY, V39, P770, DOI 10.1002/hep.20092
   Loguercio C, 2005, J CLIN GASTROENTEROL, V39, P540, DOI 10.1097/01.mcg.0000165671.25272.0f
   London Roslyn M, 2007, Clin Liver Dis, V11, P55, DOI 10.1016/j.cld.2007.02.010
   LUDWIG J, 1980, MAYO CLIN PROC, V55, P434
   LUYCKX FH, 1998, INT J RELAT METAB DI, V22, P22
   Marchesini G, 2001, DIABETES, V50, P1844, DOI 10.2337/diabetes.50.8.1844
   Marchesini G, 2001, LANCET, V358, P893, DOI 10.1016/S0140-6736(01)06042-1
   Mathieson NL, 1999, SCAND J GASTROENTERO, V34, P55
   Matteoni CA, 1999, GASTROENTEROLOGY, V116, P1413, DOI 10.1016/S0016-5085(99)70506-8
   McCullough AJ., 2005, Fatty liver disease: NASH and related disorders, P23
   Morita Y, 2005, HEPATO-GASTROENTEROL, V52, P1338
   Morra R, 2007, ALIMENT PHARM THER, V26, P847, DOI 10.1111/j.1365-2036.2007.03427.x
   Mottin CC, 2004, OBES SURG, V14, P635, DOI 10.1381/096089204323093408
   Nair S, 2004, ALIMENT PHARM THERAP, V20, P23, DOI 10.1111/j.1365-2036.2004.02025.x
   Neuschwander-Tetri BA, 2003, HEPATOLOGY, V38, P1008, DOI 10.1053/jhep.2003.50420
   Ngo Y, 2006, CLIN CHEM, V52, P1887, DOI 10.1373/clinchem.2006.070961
   Ong J, 2001, LIVER TRANSPLANT, V7, P797, DOI 10.1053/jlts.2001.24644
   ONG JP, 2006, HEPATOLOGY S1, V44, P1233
   PALMER M, 1990, GASTROENTEROLOGY, V99, P1408, DOI 10.1016/0016-5085(90)91169-7
   Pershadsingh Harrihar A, 2006, Treat Endocrinol, V5, P89, DOI 10.2165/00024677-200605020-00003
   Pessayre D, 1999, CELL BIOL TOXICOL, V15, P367, DOI 10.1023/A:1007649815992
   Promrat K, 2004, HEPATOLOGY, V39, P188, DOI 10.1002/hep.20012
   Rallidis LS, 2004, ATHEROSCLEROSIS, V174, P127, DOI 10.1016/j.atherosclerosis.2004.01.013
   Ratziu V, 2006, BMC GASTROENTEROL, V6, DOI 10.1186/1471-230X-6-6
   Ratziu V, 2005, GASTROENTEROLOGY, V128, P1898, DOI 10.1053/j.gastro.2005.03.084
   Rosenberg WMC, 2004, GASTROENTEROLOGY, V127, P1704, DOI 10.1053/j.gastro.2004.08.052
   Saadeh S, 2002, GASTROENTEROLOGY, V123, P745, DOI 10.1053/gast.2002.35354
   SABUNCU T, 2003, ROM J GASTROENTEROL, V98, P926
   Satapathy SK, 2004, AM J GASTROENTEROL, V99, P1946, DOI 10.1111/j.1572-0241.2004.40220.x
   Scheen AJ, 2004, DIABETES METAB, V30, P487, DOI 10.1016/S1262-3636(07)70146-5
   Schwimmer JB, 2005, ALIMENT PHARM THER, V21, P871, DOI 10.1111/j.1365-2036.2005.02420.x
   Setji TL, 2006, J CLIN ENDOCR METAB, V91, P1741, DOI 10.1210/jc.2005-2774
   Sjöström L, 2004, NEW ENGL J MED, V351, P2683, DOI 10.1056/NEJMoa035622
   Sloniger JA, 2005, METABOLISM, V54, P1659, DOI 10.1016/j.metabol.2005.06.016
   Solga SF, 2003, J HEPATOL, V38, P681, DOI 10.1016/S0168-8278(03)00097-7
   Tilg H, 2000, NEW ENGL J MED, V343, P1467, DOI 10.1056/NEJM200011163432007
   Ueno T, 1997, J HEPATOL, V27, P103, DOI 10.1016/S0168-8278(97)80287-5
   Vajro P, 2004, J PEDIATR GASTR NUTR, V38, P48, DOI 10.1097/00005176-200401000-00012
   VAJRO P, 1994, J PEDIATR-US, V125, P239, DOI 10.1016/S0022-3476(94)70202-0
   Vitale C, 2005, CARDIOVASC DIABETOL, V4, DOI 10.1186/1475-2840-4-6
   Wai CT, 2003, HEPATOLOGY, V38, P518, DOI 10.1053/jhep.2003.50346
   WANLESS IR, 1990, HEPATOLOGY, V12, P1106, DOI 10.1002/hep.1840120505
   Weston SR, 2005, HEPATOLOGY, V41, P372, DOI 10.1002/hep.20554
   Wieckowska A, 2007, GASTROENTEROLOGY, V132, pA728
   Yki-Jarvinen H, 2004, NEW ENGL J MED, V351, P1106, DOI 10.1056/NEJMra041001
   Yokohama S, 2004, HEPATOLOGY, V40, P1222, DOI 10.1002/hep.20420
   YOUNOSSI Z, 2008, OBES SURG IN PRESS
   YOUNOSSI ZM, 2006, LIFETIME MED EC IMPA
NR 101
TC 128
Z9 147
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-2813
EI 1365-2036
J9 ALIMENT PHARM THER
JI Aliment. Pharmacol. Ther.
PD JUL 1
PY 2008
VL 28
IS 1
BP 2
EP 12
DI 10.1111/j.1365-2036.2008.03710.x
PG 11
WC Gastroenterology & Hepatology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Pharmacology & Pharmacy
GA 308MT
UT WOS:000256395400001
PM 18410557
OA Bronze
DA 2025-06-11
ER

PT J
AU Swartz, HA
   Rucci, P
   Thase, ME
   Wallace, M
   Carretta, E
   Celedonia, KL
   Frank, E
AF Swartz, Holly A.
   Rucci, Paola
   Thase, Michael E.
   Wallace, Meredith
   Carretta, Elisa
   Celedonia, Karen L.
   Frank, Ellen
TI Psychotherapy Alone and Combined With Medication as Treatments for
   Bipolar II Depression: A Randomized Controlled Trial
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID METABOLIC SYNDROME; RATING-SCALE; DISORDER; SCHIZOPHRENIA; RELIABILITY;
   QUETIAPINE; SPECTRUM; RISK; ANTIPSYCHOTICS; MONOTHERAPY
AB Objective: Bipolar II disorder (BP-II) is associated with marked morbidity and mortality. Quetiapine, the treatment with greatest evidence for efficacy in BP-II depression, is associated with metabolic burden. Psychotherapy, a treatment with few side effects, has not been systematically evaluated in BP-II. This study compared psychotherapy plus placebo to psychotherapy plus pharmacotherapy as treatments for BP-II depression.
   Methods: From 2010 to 2015, unmedicated adults (n = 92) with DSM-IV-TR BP-II depression were randomly assigned to weekly sessions of Interpersonal and Social Rhythm Therapy (IPSRT) plus placebo or IPSRT plus quetiapine and followed for 20 weeks.
   Results: For primary outcomes, IPSRT + quetiapine yielded significantly faster improvement on 17-item Hamilton Depression Rating Scale (F-1,F-115.4 = 3.924, P = .048) and greater improvement on Young Mania Rating Scale (F-58.5 = 4.242, P = .044) scores. Both groups, however, improved significantly over time with comparable response rates (>= 50% reduction in depression scores): 67.4% (62/92) in the entire sample, with no between-group differences. Those randomly assigned to their preferred treatment were 4.5 times more likely to respond (OR = 4.48, 95% CI = 1.20-16.77, P = .026). IPSRT + quetiapine assignment was associated with significantly higher body mass index over time (F-67.96 = 6.671, P = .012) and rates of dry mouth (79% v. 58%; chi(2) = 4.0, P = .046) and a trend toward more complaints of oversedation (100% vs 92%; chi(2) = 3.4, P = .063).
   Conclusions: IPSRT plus quetiapine resulted in greater symptomatic improvement but also more side effects than IPSRT alone. A subset of participants improved with IPSRT alone, although absence of an inactive comparator limits interpretation of this finding. Receipt of preferred treatment was associated with better outcomes. Harms, benefits, and preferences should be considered when recommending treatments for BP-II depression.
C1 [Swartz, Holly A.; Wallace, Meredith; Celedonia, Karen L.; Frank, Ellen] Univ Pittsburgh, Dept Psychiat, Sch Med, Pittsburgh, PA USA.
   [Rucci, Paola; Carretta, Elisa] Univ Bologna, Dept Biomed & Neuromotor Sci, Bologna, Italy.
   [Thase, Michael E.] Univ Penn, Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; University of Bologna; University of Pennsylvania
RP Swartz, HA (corresponding author), 3811 OHara St, Pittsburgh, PA 15213 USA.
EM swartzha@upmc.edu
RI Swartz, Holly/G-5887-2012; Wallace, Meredith/LXV-0747-2024
OI Rucci, Paola/0000-0002-7704-0831; Swartz, Holly/0000-0002-7611-9900
FU National Institute of Mental Health (NIMH) [R01 MH084831]
FX This study was funded by the National Institute of Mental Health (NIMH)
   R01 MH084831 (Dr Swartz, principal investigator).
CR Amer Diabet Assoc, 2004, DIABETES CARE, V27, P596, DOI 10.2337/diacare.27.2.596
   [Anonymous], 1999, Patient Rated Inventory of Side Effects (PRISE): Unpublished Rating Scale
   [Anonymous], 1994, DIAGN STAT MAN MENT
   Colom F, 2009, J AFFECT DISORDERS, V112, P30, DOI 10.1016/j.jad.2008.03.023
   Correll CU, 2015, WORLD PSYCHIATRY, V14, P119, DOI 10.1002/wps.20204
   Correll CU, 2008, BIPOLAR DISORD, V10, P788, DOI 10.1111/j.1399-5618.2008.00625.x
   CORYELL W, 1989, PSYCHOL MED, V19, P129, DOI 10.1017/S0033291700011090
   Dunayevich E, 2000, J CLIN PSYCHIAT, V61, P134
   First M.B., 2016, Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version
   First MB., 1997, Structured Clinical Interview for DSM-IV Axis I Disorders-Clinican Version (SCID-CV)
   Frank, 2005, TREATING BIPOLAR DIS
   Frank E, 2005, ARCH GEN PSYCHIAT, V62, P996, DOI 10.1001/archpsyc.62.9.996
   Goldberg JF, 2009, AM J PSYCHIAT, V166, P173, DOI 10.1176/appi.ajp.2008.08050746
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Henry C, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-79
   Judd LL, 2003, J AFFECT DISORDERS, V73, P19, DOI 10.1016/S0165-0327(02)00324-5
   Kahn RS, 2008, LANCET, V371, P1085, DOI 10.1016/S0140-6736(08)60486-9
   Kane JM, 2002, AM J PSYCHIAT, V159, P1, DOI 10.1176/appi.ajp.159.1.1
   Klerman GL., 1984, INTERPERSONAL PSYCHO
   Kraemer HC, 2002, ARCH GEN PSYCHIAT, V59, P877, DOI 10.1001/archpsyc.59.10.877
   Maina G, 2007, J CLIN PSYCHIAT, V68, P207, DOI 10.4088/JCP.v68n0205
   McElroy SL, 2016, ACTA PSYCHIAT SCAND, V133, P144, DOI 10.1111/acps.12460
   McEvoy JP, 2007, AM J PSYCHIAT, V164, P1050, DOI 10.1176/appi.ajp.164.7.1050
   Merikangas KR, 2007, ARCH GEN PSYCHIAT, V64, P543, DOI 10.1001/archpsyc.64.5.543
   Miklowitz DJ, 2007, ARCH GEN PSYCHIAT, V64, P419, DOI 10.1001/archpsyc.64.4.419
   MONK TH, 1990, J NERV MENT DIS, V178, P120, DOI 10.1097/00005053-199002000-00007
   MONTGOMERY SA, 1979, BRIT J PSYCHIAT, V134, P382, DOI 10.1192/bjp.134.4.382
   Newcomer JW, 2005, CNS DRUGS, V19, P1
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Parikh SV, 2012, J CLIN PSYCHIAT, V73, P803, DOI 10.4088/JCP.11m07343
   Posternak MA, 2004, J NERV MENT DIS, V192, P95, DOI 10.1097/01.nmd.0000110280.19284.47
   Rosa Adriane R, 2007, Clin Pract Epidemiol Ment Health, V3, P5, DOI 10.1186/1745-0179-3-5
   Shear MK, 2001, J PSYCHIATR RES, V35, P59, DOI 10.1016/S0022-3956(01)00002-4
   SMITH CS, 1989, J APPL PSYCHOL, V74, P728, DOI 10.1037/0021-9010.74.5.728
   Spearing MK, 1997, PSYCHIAT RES, V73, P159, DOI 10.1016/S0165-1781(97)00123-6
   Swartz HA, 2005, BIPOLAR DISORD, V7, P192, DOI 10.1111/j.1399-5618.2005.00179.x
   Swartz HA, 2012, J CLIN PSYCHIAT, V73, P1563, DOI 10.4088/JCP.12ac08227
   Swartz HA, 2012, PROF PSYCHOL-RES PR, V43, P145, DOI 10.1037/a0027671
   Swartz HA, 2012, BIPOLAR DISORD, V14, P211, DOI 10.1111/j.1399-5618.2012.00988.x
   Swartz HA, 2011, J CLIN PSYCHIAT, V72, P356, DOI [10.4088/JCP.8133tx4c, 10.4088/JCP.09r05192gre]
   Swartz HA, 2008, SANTE MENT QUE, V33, P151, DOI 10.7202/019673ar
   Swartz HA, 2009, BIPOLAR DISORD, V11, P89, DOI 10.1111/j.1399-5618.2008.00629.x
   THASE ME, 1991, PSYCHOPHARMACOL BULL, V27, P17
   Vancampfort D, 2013, AM J PSYCHIAT, V170, P265, DOI 10.1176/appi.ajp.2012.12050620
   Vandenberghe F, 2015, J CLIN PSYCHIAT, V76, pE1417, DOI 10.4088/JCP.14m09358
   Wagner E F, 1992, J Psychother Pract Res, V1, P280
   Young AH, 2013, INT J BIPOLAR DISORD, V1, DOI 10.1186/2194-7511-1-10
   YOUNG RC, 1978, BRIT J PSYCHIAT, V133, P429, DOI 10.1192/bjp.133.5.429
NR 48
TC 27
Z9 30
U1 1
U2 25
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD MAR-APR
PY 2018
VL 79
IS 2
BP 7
EP +
AR 16m11027
DI 10.4088/JCP.16m11027
PG 13
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA GK7NE
UT WOS:000436392200030
PM 28703949
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ozdemir, AC
   Wynn, GM
   Vester, A
   Weitzmann, MN
   Neigh, GN
   Srinivasan, S
   Rudd, MK
AF Ozdemir, Alev Cagla
   Wynn, Grace M.
   Vester, Aimee
   Weitzmann, M. Neale
   Neigh, Gretchen N.
   Srinivasan, Shanthi
   Rudd, M. Katharine
TI GNB3 overexpression causes obesity and metabolic syndrome
SO PLOS ONE
LA English
DT Article
ID WHITE ADIPOSE-TISSUE; BROWN ADIPOCYTES; OPEN-FIELD; SOCIAL-INTERACTION;
   MOLECULAR-BASIS; GAMMA-SUBUNITS; BODY-WEIGHT; G-PROTEINS; MICE; FAT
AB The G-protein beta subunit 3 (GNB3) gene has been implicated in obesity risk; however, the molecular mechanism of GNB3-related disease is unknown. GNB3 duplication is responsible for a syndromic form of childhood obesity, and an activating DNA sequence variant (C825T) in GNB3 is also associated with obesity. To test the hypothesis that GNB3 overexpression causes obesity, we created bacterial artificial chromosome (BAC) transgenic mice that carry an extra copy of the human GNB3 risk allele. Here we show that GNB3-T/+ mice have increased adiposity, but not greater food intake or a defect in satiety. GNB3-T/+ mice have elevated fasting plasma glucose, insulin, and C-peptide, as well as glucose intolerance, indicating type 2 diabetes. Fasting plasma leptin, triglycerides, cholesterol and phospholipids are elevated, suggesting metabolic syndrome. Based on a battery of behavioral tests, GNB3-T/+ mice did not exhibit anxiety-or depressive-like phenotypes. GNB3-T/+ and wild-type animals have similar activity levels and heat production; however, GNB3-T/+ mice exhibit dysregulation of acute thermogenesis. Finally, Ucp1 expression is significantly lower in white adipose tissue (WAT) in GNB3-T/+ mice, suggestive of WAT remodeling that could lead to impaired cellular thermogenesis. Taken together, our study provides the first functional link between GNB3 and obesity, and presents insight into novel pathways that could be applied to combat obesity and type 2 diabetes.
C1 [Ozdemir, Alev Cagla; Wynn, Grace M.; Rudd, M. Katharine] Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA 30322 USA.
   [Vester, Aimee] Emory Univ, Dept Environm Hlth Sci, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
   [Weitzmann, M. Neale] Emory Univ, Sch Med, Div Endocrinol Metab & Lipids, Atlanta, GA USA.
   [Weitzmann, M. Neale; Srinivasan, Shanthi] Atlanta VA Med Ctr, Decatur, GA USA.
   [Neigh, Gretchen N.] Emory Univ, Sch Med, Dept Physiol, Atlanta, GA 30322 USA.
   [Neigh, Gretchen N.] Virginia Commonwealth Univ, Dept Anat & Neurobiol, Richmond, VA USA.
   [Srinivasan, Shanthi] Emory Univ, Sch Med, Div Digest Dis, Atlanta, GA USA.
   [Rudd, M. Katharine] Lab Corp Amer Holdings, Ctr Mol Biol & Pathol, Res Triangle Pk, NC 27709 USA.
C3 Emory University; Emory University; Rollins School Public Health; Emory
   University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Atlanta VA Health Care System; Atlanta VA Medical
   Center; Emory University; Virginia Commonwealth University; Emory
   University
RP Rudd, MK (corresponding author), Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA 30322 USA.; Rudd, MK (corresponding author), Lab Corp Amer Holdings, Ctr Mol Biol & Pathol, Res Triangle Pk, NC 27709 USA.
EM ruddm2@labcorp.com
RI Neigh, Gretchen/AAW-5691-2020; Srinivasan, Shanthi/A-6133-2013
FU Emory Discovery Fund; Emory University School of Medicine; Department of
   Human Genetics at Emory University; Emory Integrated Core Facilities
FX This work received support from the Emory Discovery Fund, an internal
   grant from the Department of Human Genetics at Emory University. Some
   experiments were conducted with the Emory Integrated Genomics Core
   (EIGC), which is subsidized by the Emory University School of Medicine
   and is one of the Emory Integrated Core Facilities.
CR Blakemore AIF, 2010, ANN NY ACAD SCI, V1214, P180, DOI 10.1111/j.1749-6632.2010.05880.x
   Bourne HR, 1997, CURR OPIN CELL BIOL, V9, P134, DOI 10.1016/S0955-0674(97)80054-3
   Burgado J, 2014, BEHAV BRAIN RES, V275, P120, DOI 10.1016/j.bbr.2014.08.060
   Cannon B, 2004, PHYSIOL REV, V84, P277, DOI 10.1152/physrev.00015.2003
   Carola V, 2002, BEHAV BRAIN RES, V134, P49, DOI 10.1016/S0166-4328(01)00452-1
   CHAN JM, 1994, DIABETES CARE, V17, P961, DOI 10.2337/diacare.17.9.961
   Choleris E, 2001, NEUROSCI BIOBEHAV R, V25, P235, DOI 10.1016/S0149-7634(01)00011-2
   Choquet H, 2011, CURR GENOMICS, V12, P154, DOI 10.2174/138920211795677921
   Choquet H, 2011, CURR GENOMICS, V12, P169, DOI 10.2174/138920211795677895
   COUSIN B, 1992, J CELL SCI, V103, P931
   Crowley VEF, 2008, ANN CLIN BIOCHEM, V45, P245, DOI 10.1258/acb.2007.007193
   Feldmann HM, 2009, CELL METAB, V9, P203, DOI 10.1016/j.cmet.2008.12.014
   FILE SE, 1980, J NEUROSCI METH, V2, P219, DOI 10.1016/0165-0270(80)90012-6
   File SE, 2003, EUR J PHARMACOL, V463, P35, DOI 10.1016/S0014-2999(03)01273-1
   Ford CE, 1998, SCIENCE, V280, P1271, DOI 10.1126/science.280.5367.1271
   Fukumoto K, 2014, PSYCHOPHARMACOLOGY, V231, P2291, DOI 10.1007/s00213-013-3378-0
   Ghorbani M, 1997, INT J OBESITY, V21, P465, DOI 10.1038/sj.ijo.0800432
   Goldlust IS, 2013, P NATL ACAD SCI USA, V110, P14990, DOI 10.1073/pnas.1305999110
   Guerra C, 1998, J CLIN INVEST, V102, P412, DOI 10.1172/JCI3155
   Haslam DW, 2005, LANCET, V366, P1197, DOI 10.1016/S0140-6736(05)67483-1
   Himms-Hagen J, 2000, AM J PHYSIOL-CELL PH, V279, pC670, DOI 10.1152/ajpcell.2000.279.3.C670
   Klenke S, 2011, PHARMACOGENET GENOM, V21, P594, DOI 10.1097/FPC.0b013e3283491153
   Krumins AM, 2006, J BIOL CHEM, V281, P10250, DOI 10.1074/jbc.M511551200
   Lania A, 2001, EUR J ENDOCRINOL, V145, P543, DOI 10.1530/eje.0.1450543
   Moxham CM, 1996, NATURE, V379, P840, DOI 10.1038/379840a0
   Neves SR, 2002, SCIENCE, V296, P1636, DOI 10.1126/science.1071550
   NJUNGE K, 1991, PHARMACOL BIOCHEM BE, V38, P63, DOI 10.1016/0091-3057(91)90590-X
   O'Rahilly S, 2009, NATURE, V462, P307, DOI 10.1038/nature08532
   Obregon MJ, 2014, FRONT PHYSIOL, V5, DOI 10.3389/fphys.2014.00479
   Offermanns S, 1998, ONCOGENE, V17, P1375, DOI 10.1038/sj.onc.1202173
   Petrovic N, 2010, J BIOL CHEM, V285, P7153, DOI 10.1074/jbc.M109.053942
   Poon LSW, 2009, CELL SIGNAL, V21, P737, DOI 10.1016/j.cellsig.2009.01.018
   Prut L, 2003, EUR J PHARMACOL, V463, P3, DOI 10.1016/S0014-2999(03)01272-X
   Rong JX, 2007, DIABETES, V56, P1751, DOI 10.2337/db06-1135
   Sabin MA, 2011, BEST PRACT RES CL EN, V25, P207, DOI 10.1016/j.beem.2010.09.010
   Sargolini F, 2003, BEHAV BRAIN RES, V138, P153, DOI 10.1016/S0166-4328(02)00238-3
   Scacchi M, 1999, INT J OBESITY, V23, P260, DOI 10.1038/sj.ijo.0800807
   Schneider CA, 2012, NAT METHODS, V9, P671, DOI 10.1038/nmeth.2089
   Seale P, 2008, NATURE, V454, P961, DOI 10.1038/nature07182
   Siffert W, 1998, NAT GENET, V18, P45, DOI 10.1038/ng0198-45
   STUNKARD AJ, 1986, NEW ENGL J MED, V314, P193, DOI 10.1056/NEJM198601233140401
   STUNKARD AJ, 1990, NEW ENGL J MED, V322, P1483, DOI 10.1056/NEJM199005243222102
   Tang YP, 1999, NATURE, V401, P63, DOI 10.1038/43432
   Teerds KJ, 2011, HUM REPROD UPDATE, V17, P667, DOI 10.1093/humupd/dmr017
   Wettschureck N, 2005, PHYSIOL REV, V85, P1159, DOI 10.1152/physrev.00003.2005
   World Health Organization, 2021, Obesity and overweight, fact sheet
   Wu J, 2012, CELL, V150, P366, DOI 10.1016/j.cell.2012.05.016
   Xia QH, 2013, ANN NY ACAD SCI, V1281, P178, DOI 10.1111/nyas.12020
   Xue BZ, 2005, MOL CELL BIOL, V25, P8311, DOI 10.1128/MCB.25.18.8311-8322.2005
   Ye YC, 2014, CELL SIGNAL, V26, P2514, DOI 10.1016/j.cellsig.2014.07.030
   ZHANG YY, 1994, NATURE, V372, P425, DOI 10.1038/372425a0
NR 51
TC 11
Z9 14
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 5
PY 2017
VL 12
IS 12
AR e0188763
DI 10.1371/journal.pone.0188763
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FO8CU
UT WOS:000417110700022
PM 29206867
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Bazmi, S
   Sepehrinia, M
   Pourmontaseri, H
   Bazyar, H
   Vahid, F
   Farjam, M
   Dehghan, A
   Hebert, JR
   Homayounfar, R
   Shakouri, N
AF Bazmi, Sina
   Sepehrinia, Matin
   Pourmontaseri, Hossein
   Bazyar, Hadi
   Vahid, Farhad
   Farjam, Mojtaba
   Dehghan, Azizallah
   Hebert, James R.
   Homayounfar, Reza
   Shakouri, Negin
TI Androgenic alopecia is associated with higher dietary inflammatory index
   and lower antioxidant index scores
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE antioxidants; diet; pattern baldness; hair loss; metabolic syndrome;
   inflammation
ID METABOLIC SYNDROME; DISEASE; ONSET; RISK
AB Background Androgenic alopecia (AGA), the most prevalent hair loss type, causes major psychological distress and reduced quality of life. A definite and safe cure/prevention for this condition is still lacking. The role of oxidative stress and inflammation in AGA pathogenesis prompted us to investigate the association between dietary antioxidant index (DAI) and energy-adjusted dietary inflammatory index (E-DII) with AGA.Methods The investigation was designed based on data from 10,138 participants from the Fasa Adult Cohort Study (FACS). DAI and energy-adjusted DII (E-DII) were calculated utilizing a validated 125-item food frequency questionnaire (FFQ). A physician diagnosed AGA. Logistic regression models were utilized to evaluate the association of DAI and E-DII with AGA.Results After exclusion, 9,647 participants (44.0% men, mean age: 48.6 +/- 9.5 years) consisting of 7,348 participants with AGA entered the analyses. Higher DAI was associated with 10% lower AGA odds, while higher E-DII showed 4% higher AGA odds after adjusting for various confounding variables. However, significant associations were found only among women, and adjusting for metabolic syndrome (MetS) made the E-DII-AGA association insignificant.Conclusion Antioxidant-rich diets protect against AGA, while pro-inflammatory diets increase the risk, likely through developing MetS. Patient nutrition is frequently overlooked in clinical practice, yet it plays a crucial role, especially for women genetically predisposed to androgenetic alopecia. Dietary changes, such as reducing pro-inflammatory foods (like trans and saturated fats) and increasing anti-inflammatory options (fruits and vegetables), can help prevent hair loss and mitigate its psychological impacts, ultimately lowering future treatment costs.
C1 [Bazmi, Sina; Sepehrinia, Matin; Pourmontaseri, Hossein] Fasa Univ Med Sci, Student Res Comm, Fasa, Iran.
   [Sepehrinia, Matin; Farjam, Mojtaba; Dehghan, Azizallah; Shakouri, Negin] Fasa Univ Med Sci, Noncommunicable Dis Res Ctr, Fasa, Iran.
   [Bazyar, Hadi] Sirjan Sch Med Sci, Dept Publ Hlth, Sirjan, Iran.
   [Vahid, Farhad] Luxembourg Inst Hlth, Dept Precis Hlth, Nutr & Hlth Res Grp, Strassen, Luxembourg.
   [Hebert, James R.] Univ South Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC USA.
   [Hebert, James R.] Univ South Carolina, Statewide Canc Prevent & Control Program, Columbia, SC USA.
   [Homayounfar, Reza] Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, WHO Collaborating Ctr, Tehran, Iran.
C3 Luxembourg Institute of Health; University of South Carolina System;
   University of South Carolina Columbia; University of South Carolina
   System; University of South Carolina Columbia; World Health
   Organization; Shahid Beheshti University Medical Sciences
RP Shakouri, N (corresponding author), Fasa Univ Med Sci, Noncommunicable Dis Res Ctr, Fasa, Iran.; Homayounfar, R (corresponding author), Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, WHO Collaborating Ctr, Tehran, Iran.
EM shakouri.negin92@gmail.com; r_homayounfar@yahoo.com
RI Vahid, Farhad/L-7547-2018; Dehghan, Azizallah/ABG-3704-2020; bazyar,
   hadi/AFG-3161-2022; Farjam, Mojtaba/O-3475-2017; Sepehrinia,
   Matin/KQU-1834-2024; Homayounfar, Reza/L-8813-2017; Shakouri,
   Negin/KMX-9685-2024; Hebert, James/IUO-5628-2023
OI Dehghan, Azizallah/0000-0002-7345-0796
FX The author(s) declare that no financial support was received for the
   research, authorship, and/or publication of this article.
CR Abdollahpour I, 2022, NUTR NEUROSCI, V25, P379, DOI 10.1080/1028415X.2020.1755792
   Akbas A, 2022, J COSMET DERMATOL-US, V21, P3431, DOI 10.1111/jocd.14655
   Allahyari P, 2023, INT J VITAM NUTR RES, V93, P483, DOI 10.1024/0300-9831/a000750
   Andy G, 2019, DERMATOL THER, V32, DOI 10.1111/dth.12647
   Anzai A, 2020, DERMATOL THER, V33, DOI 10.1111/dth.13293
   Cavicchia PP, 2009, J NUTR, V139, P2365, DOI 10.3945/jn.109.114025
   Chen S, 2022, DERMATOLOGY THER, V12, P2233, DOI 10.1007/s13555-022-00799-7
   Chen XJ, 2023, DIABETOL METAB SYNDR, V15, DOI 10.1186/s13098-023-01150-6
   Chew EGY, 2022, EXP DERMATOL, V31, P906, DOI 10.1111/exd.14536
   Deng YQ, 2023, DERMATOLOGY, V239, P533, DOI 10.1159/000530681
   Drake L, 2023, JAMA DERMATOL, V159, P79, DOI 10.1001/jamadermatol.2022.4867
   Ellis Justine A, 2002, Expert Rev Mol Med, V4, P1, DOI 10.1017/S1462399402005112
   Erdogan HK, 2017, J COSMET DERMATOL-US, V16, P527, DOI 10.1111/jocd.12300
   Farazi M, 2023, CRIT REV FOOD SCI, V63, P57, DOI 10.1080/10408398.2021.1943646
   Farjam M, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-3760-z
   Flieger J, 2021, MATERIALS, V14, DOI 10.3390/ma14154135
   Fortes C, 2018, ARCH DERMATOL RES, V310, P71, DOI 10.1007/s00403-017-1799-z
   Furman D, 2019, NAT MED, V25, P1822, DOI 10.1038/s41591-019-0675-0
   Galland L, 2010, NUTR CLIN PRACT, V25, P634, DOI 10.1177/0884533610385703
   Gokce Nuriye, 2022, J Prev Med Hyg, V63, pE228, DOI 10.15167/2421-4248/jpmh2022.63.2S3.2765
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hébert JR, 2019, ADV NUTR, V10, P185, DOI 10.1093/advances/nmy071
   Homayounfar R, 2023, INT J EPIDEMIOL, V52, pE172, DOI 10.1093/ije/dyac241
   Hu WQ, 2024, BIOL RES NURS, V26, P150, DOI 10.1177/10998004231198166
   Khantham C, 2022, PLANTS-BASEL, V11, DOI 10.3390/plants11030330
   Kondrakhina IN, 2021, BIOL TRACE ELEM RES, V199, P3232, DOI 10.1007/s12011-020-02468-2
   Lai CH, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0079789
   Lolli F, 2017, ENDOCRINE, V57, P9, DOI 10.1007/s12020-017-1280-y
   O'Connor K, 2021, CLIN DERMATOL, V39, P809, DOI 10.1016/j.clindermatol.2021.05.008
   Pham CT, 2020, SKIN APPENDAGE DISOR, V6, P88, DOI 10.1159/000504786
   Prie B E, 2016, J Med Life, V9, P79
   Qiu YQ, 2022, ACTA DERM-VENEREOL, V102, DOI 10.2340/actadv.v101.1012
   RUSHTON DH, 1990, BRIT J DERMATOL, V123, P187, DOI 10.1111/j.1365-2133.1990.tb01846.x
   SCHMIDT JB, 1991, GYNECOL OBSTET INVES, V31, P235, DOI 10.1159/000293166
   Shimizu Y, 2022, REGEN THER, V21, P527, DOI 10.1016/j.reth.2022.10.005
   Shivappa N, 2014, PUBLIC HEALTH NUTR, V17, P1689, DOI 10.1017/S1368980013002115
   Trüeb RM, 2002, EXP GERONTOL, V37, P981, DOI 10.1016/S0531-5565(02)00093-1
   Vahid F, 2023, J AM NUTR ASSOC, V42, P386, DOI 10.1080/07315724.2022.2056543
   Vahid F, 2022, MEDITERR J NUTR META, V15, P103, DOI 10.3233/MNM-211503
   Vahid F, 2021, CLIN NUTR ESPEN, V41, P360, DOI 10.1016/j.clnesp.2020.10.020
   Vahid F, 2020, NUTR METAB, V17, DOI 10.1186/s12986-020-00529-w
   Wang M, 2023, FOOD FUNCT, V14, P9279, DOI [10.1039/D3FO01157G, 10.1039/d3fo01157g]
   Wright ME, 2004, AM J EPIDEMIOL, V160, P68, DOI 10.1093/aje/kwh173
   Yamamoto K, 2003, VET HUM TOXICOL, V45, P85
   Yaribeygi H, 2019, J CELL PHYSIOL, V234, P8152, DOI 10.1002/jcp.27603
   Yi Q, 2021, PUBLIC HEALTH NUTR, V24, P5463, DOI 10.1017/S1368980021000288
   Yu YC, 2022, INT J CANCER, V150, P1599, DOI 10.1002/ijc.33925
   Yuan AR, 2021, ACS NANO, V15, P13759, DOI 10.1021/acsnano.1c05272
   Zhang CH, 2022, NANO LETT, V22, P8592, DOI 10.1021/acs.nanolett.2c03119
NR 49
TC 4
Z9 4
U1 4
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD AUG 15
PY 2024
VL 11
AR 1433962
DI 10.3389/fnut.2024.1433962
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA E4I8F
UT WOS:001302665000001
PM 39211830
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nakama, RP
   dos Santos, LF
   Berto-Pereira, L
   de Rossi, LS
   Malvezi, AD
   Lovo-Martins, MI
   Cardoso, APC
   de Freitas, AMD
   Martins-Pinge, MC
   Pinge, P
AF Nakama, Raquel Pires
   dos Santos, Lucas Felipe
   Berto-Pereira, Leonardo
   de Rossi, Lucas Sobral
   Malvezi, Aparecida Donizette
   Lovo-Martins, Maria Isabel
   Cardoso, Ana Paula Canizares
   de Freitas, Andressa Mendes Dionisio
   Martins-Pinge, Marli Cardoso
   Pinge-Filho, Phileno
TI Metabolic syndrome induces benefits in mice experiencing severe sepsis,
   comparable to the effects of low-dose aspirin pretreatment in septic
   mice lacking metabolic syndrome
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Aspirin; Inflammation; Sepsis; Obesity; Nitric oxide; Cytokines
ID OXIDATIVE STRESS; NITRIC-OXIDE; OBESITY; HYPOGLYCEMIA; HYPERTENSION;
   ASSOCIATION; PREVENTION; APOPTOSIS; FEMALE; SHOCK
AB Background: Sepsis is a complex condition characterized by systemic host inflammation caused by an infection. Experimental and observational studies indicate that obesity, one of the components of metabolic syndrome (MetS), or aspirin (ASA) treatment could be associated with sepsis survival. However, the effects of ASA on septic mice with MetS-induced conditions have not been explored. Methods: Swiss mice were administered monosodium glutamate (MSG) (4 mg/kg) during their first 5 days of life for MetS induction, while the control mice received an equimolar saline solution. MetS was validated in male mice on their 60th day of life. ASA treatment was administered for 15 days prior to sepsis (40 mg/kg). On the 75th day, sepsis was induced in MetS and control mice through cecal ligation and puncture (CLP). The effects of ASA on septic mice with MSG-induced MetS were assessed by determining survival rates, quantification of nitric oxide (NO), and cytokine levels in the plasma, while correlating these data with hematological, blood glucose and cardiovascular parameters. Results: MetS was validated by Lee-Index ( root body weight/naso-anal length x1000), hypertension, and hyper3 glycemia in animals receiving MSG as neonates. In control animals, severe sepsis promoted hypoglycemia, which was associated with mortality, as well as increased plasma NO levels, hypotension, hematological alterations, and elevation of proinflammatory cytokines. In contrast, MetS and pre-treatment with ASA were able to prevent sepsis-related alterations. Conclusions: MetS and ASA pre-treatment provided protection against severe sepsis. However, ASA was ineffective in mice with MetS undergoing severe sepsis.
C1 [Nakama, Raquel Pires; de Rossi, Lucas Sobral; Malvezi, Aparecida Donizette; Lovo-Martins, Maria Isabel; Cardoso, Ana Paula Canizares; Martins-Pinge, Marli Cardoso; Pinge-Filho, Phileno] Univ Estadual Londrina, Ctr Biol Sci, Dept Immunol Parasitol & Gen Pathol, Lab Expt Immunopathol, Londrina, PR, Brazil.
   [dos Santos, Lucas Felipe; Pinge-Filho, Phileno] Univ Estadual Londrina, Ctr Biol Sci, Dept Microbiol, Lab Microorganism Mol Biol, Londrina, PR, Brazil.
   [de Freitas, Andressa Mendes Dionisio] Univ Estadual Londrina, Ctr Biol Sci, Dept Physiol Sci, Lab Pharmacol Inflammat, Londrina, PR, Brazil.
   [Berto-Pereira, Leonardo; Martins-Pinge, Marli Cardoso] Univ Estadual Londrina, Ctr Biol Sci, Dept Physiol Sci, Lab Cardiovasc Physiol & Physiopathol, Londrina, PR, Brazil.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   Universidade Estadual de Londrina; Universidade Estadual de Londrina
RP Pinge, P (corresponding author), Univ Estadual Londrina, Ctr Biol Sci, Dept Immunol Parasitol & Gen Pathol, Lab Expt Immunopathol, Londrina, PR, Brazil.; Pinge, P (corresponding author), Univ Estadual Londrina, Ctr Biol Sci, Dept Microbiol, Lab Microorganism Mol Biol, Londrina, PR, Brazil.
EM pingefilho@uel.br
RI Pinge-Filho, Phileno/G-2844-2012; Pinge, Marli/C-4417-2014; Cardoso, Ana
   Paula/ITV-0081-2023; Freitas, Andressa/B-7264-2012
OI Freitas, Andressa/0000-0001-8453-7742
FU CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior);
   CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
   [306187/2022-1, 304114/2022-7]; Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico [404420/2023-0]; Fundacao Araucaria
   [376/2022/09/2021]; Secretaria de Estadoda Ciencia, Tecnologia, e Ensino
   Superiordo Parana [4560.19.571.06.6153]
FX The authors are grateful for the support provided by CAPES (Coordenacao
   de Aperfeicoamento de Pessoal de Nivel Superior) for the fellowships
   granted to RPN, LFS, LBP and LSR, as well as CNPq (Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico) for the research fellowships
   awarded to MCMP (process number 306187/2022-1) and PPF (process number
   304114/2022-7). This work was supported by Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (grant number 404420/2023-0),
   Fundacao Araucaria (grant number 376/2022/09/2021) and Secretaria de
   Estadoda Ciencia, Tecnologia, e Ensino Superiordo Parana (grant number
   4560.19.571.06.6153). We thank Guilherme Bartolomeu Goncalves, MSc, from
   the Laboratory of Molecular Biology of Microorganisms, State University
   of Londrina, for proof reading this manuscript for grammatical accuracy.
CR Adamzik M, 2012, CRIT CARE, V16, DOI 10.1186/cc11425
   Al Harbi SA, 2016, BMC PHARMACOL TOXICO, V17, DOI 10.1186/s40360-016-0047-z
   Bellomo R, 2011, CRIT CARE MED, V39, P2367, DOI 10.1097/CCM.0b013e31822a5be5
   BERNARDIS LL, 1968, J ENDOCRINOL, V40, P527, DOI 10.1677/joe.0.0400527
   Calis J, 2013, NEW ENGL J MED, V369, P2062, DOI 10.1056/NEJMc1312359
   Celes MRN, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0068809
   Chen SN, 2023, FRONT PHARMACOL, V14, DOI 10.3389/fphar.2023.1186384
   Collison K.S, 2012, Nutrit. Metabol., V9, P1, DOI [10.1186/1743-7075- 9-58, DOI 10.1186/1743-7075-9-58]
   Critchley JA, 2018, DIABETES CARE, V41, P2127, DOI 10.2337/dc18-0287
   Lucchetti BFC, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-55363-9
   da Cunha NV, 2014, AM J PHYSIOL-HEART C, V306, DOI 10.1152/ajpheart.00520.2013
   Eisen DP, 2021, LANCET RESP MED, V9, P186, DOI 10.1016/S2213-2600(20)30411-2
   El Midaoui A, 2002, J HYPERTENS, V20, P1407, DOI 10.1097/00004872-200207000-00028
   Emanuela F, 2012, J NUTR METAB, V2012, DOI 10.1155/2012/476380
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Falagas ME, 2006, LANCET INFECT DIS, V6, P438, DOI 10.1016/S1473-3099(06)70523-0
   Girardot T, 2017, APOPTOSIS, V22, P295, DOI 10.1007/s10495-016-1325-3
   Goossens C, 2019, CRIT CARE, V23, DOI 10.1186/s13054-019-2506-6
   Hernández-Bautista RJ, 2014, INT J MOL SCI, V15, P11473, DOI 10.3390/ijms150711473
   HINSHAW LB, 1967, J PHARMACOL EXP THER, V157, P665
   Hsu WT, 2022, ANESTH ANALG, V135, P110, DOI 10.1213/ANE.0000000000005943
   Huang M, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20215376
   Hughes KJ, 2009, AM J PHYSIOL-ENDOC M, V297, pE1187, DOI 10.1152/ajpendo.00214.2009
   Kellum JA, 2022, CRIT CARE CLIN, V38, P195, DOI 10.1016/j.ccc.2021.11.013
   Kim EY, 2020, J CLIN INVEST, V130, P3238, DOI 10.1172/JCI128075
   Kirkeboen KA, 1999, ACTA ANAESTH SCAND, V43, P275
   Kuperman EF, 2013, BMC INFECT DIS, V13, DOI 10.1186/1471-2334-13-377
   Liu D, 2022, MILITARY MED RES, V9, DOI 10.1186/s40779-022-00422-y
   Lovo-Martins M.I., 2020, Antimicrob Agents Chemother, V64, DOI [10.1128/aac. 00069-20, DOI 10.1128/AAC.00069-20]
   Lumeng CN, 2011, J CLIN INVEST, V121, P2111, DOI 10.1172/JCI57132
   Maitra SR, 2000, SHOCK, V13, P379, DOI 10.1097/00024382-200005000-00006
   Malvezi AD, 2004, FEMS IMMUNOL MED MIC, V41, P69, DOI 10.1016/j.femsim.2004.01.005
   Martin JM, 2016, INT J ENDOCRINOL, V2016, DOI 10.1155/2016/9242319
   Montinari MR, 2019, VASC PHARMACOL, V113, P1, DOI 10.1016/j.vph.2018.10.008
   Mortensen EM, 2010, AM J MED SCI, V339, P239, DOI 10.1097/MAJ.0b013e3181ca43fe
   Nakama RP, 2021, LIFE SCI, V286, DOI 10.1016/j.lfs.2021.120033
   NATHAN C, 1994, J BIOL CHEM, V269, P13725
   Navarro-Gonzálvez JA, 1998, CLIN CHEM, V44, P679
   Otto GP, 2013, PLATELETS, V24, P480, DOI 10.3109/09537104.2012.724482
   Patrono C, 2011, EUR HEART J, V32, P2922, DOI 10.1093/eurheartj/ehr373
   Pizarro CF, 2007, J PEDIAT, V83, pS155, DOI 10.2223/JPED.1708
   Ponsford MJ, 2020, CIRCULATION, V142, P1791, DOI 10.1161/CIRCULATIONAHA.120.050753
   Rittirsch D, 2009, NAT PROTOC, V4, P31, DOI 10.1038/nprot.2008.214
   Rusnanta F., 2021, Heart Sci. J, V4, P4, DOI [10.21776/ub.hsj.2021.002.04.2, DOI 10.21776/UB.HSJ.2021.002.04.2]
   Salomao R, 2019, BRAZ J MED BIOL RES, V52, DOI [10.1590/1414-431X20198595, 10.1590/1414-431x20198595]
   Siddiqui SA, 2020, BIOSCIENCE REP, V40, DOI 10.1042/BSR20193972
   Singer M, 2016, JAMA-J AM MED ASSOC, V315, P801, DOI 10.1001/jama.2016.0287
   Sossdorf M, 2013, CRIT CARE, V17, DOI 10.1186/cc11886
   Takeuchi O, 2010, CELL, V140, P805, DOI 10.1016/j.cell.2010.01.022
   Toner P, 2015, CRIT CARE, V19, DOI 10.1186/s13054-015-1091-6
   Torres-Dueñas D, 2007, BRIT J PHARMACOL, V152, P341, DOI 10.1038/sj.bjp.0707393
   Trivedi V, 2015, J CRIT CARE, V30, P518, DOI 10.1016/j.jcrc.2014.12.007
   Tsantes AG, 2023, LIFE-BASEL, V13, DOI 10.3390/life13020350
   Tsuneyama K, 2014, J GASTROEN HEPATOL, V29, P1736, DOI 10.1111/jgh.12610
   WICHTERMAN KA, 1980, J SURG RES, V29, P189, DOI 10.1016/0022-4804(80)90037-2
   Yeo HJ, 2023, CRIT CARE MED, V51, P742, DOI 10.1097/CCM.0000000000005801
NR 56
TC 3
Z9 3
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD SEP 30
PY 2024
VL 139
AR 112694
DI 10.1016/j.intimp.2024.112694
EA JUL 2024
PG 11
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA ZF5T3
UT WOS:001273901000001
PM 39024746
DA 2025-06-11
ER

PT J
AU Zhang, HJ
   Sun, T
   Cheng, YT
   Zhang, J
   Zhang, HX
   Krittanawong, C
   El-Am, E
   Abou Karam, R
   Wang, S
   Wang, Q
   Ma, N
AF Zhang, Hongju
   Sun, Tao
   Cheng, Yutong
   Zhang, Jing
   Zhang, HaiXia
   Krittanawong, Chayakrit
   El-Am, Edward
   Abou Karam, Roukoz
   Wang, Su
   Wang, Qian
   Ma, Ning
TI Impact of metabolic syndrome and systemic inflammation on endothelial
   function in postmenopausal women
SO TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF
   CARDIOLOGY
LA English
DT Article
DE Postmenopausal; metabolic syndrome; systemic inflammation; endothelial
   function
ID CARDIOVASCULAR RISK; DYSFUNCTION; STRESS
AB Objective: Data on the impact of metabolic syndrome (MetS) and systemic inflammation on endothelial function remains scarce. In this study, we aimed to investigate the combined effects of MetS and systemic inflammation on endothelial function in postmenopausal women.
   Methods: We identified 423 postmenopausal women from February 2019 through July 2020. MetS was diagnosed according to the International Diabetes Federation (IDF) criteria, and high sensitivity C-reaction protein (hs-CRP) was measured to assess the degree of underlying inflammation. The measurement of endothelial function was using digital arterial tonometry by assessing reactive hyperemia-induced vasodilation in one arm and adjusting for changes in the contralateral arm (reactive hyperemia index, RHI).
   Results: There were 156 patients with MetS and 267 without MetS. Compared to the group without MetS, patients with MetS had significantly lower natural logarithmic RHI (0.66 +/- 0.29 versus 0.91 +/- 0.31; p<0.001), but higher levels of hs-CRP (0.98 [0.31, 3.54] versus 0.53 [0.20, 2.14]; p<0.001). In sequential multivariable analysis, the presence of hs-CRP (.R2=0.047, p=0.004) had a significant and independent influence on natural logarithmic RHI. Furthermore, the interaction of hs-CRP*MetS was synergistically associated with endothelial dysfunction even in the fully adjusted model (beta=-0.107, 95% CI [-0.161 similar to-0.053], p=0.009).
   Conclusion: MetS and systemic inflammation are synergistically associated with endothelial dysfunction in postmenopausal women. Postmenopausal women with both these conditions appear to be at a significantly higher risk for adverse cardiovascular events.
C1 [Zhang, Hongju; Ma, Ning] Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Dept Echocardiog, Beijing, Peoples R China.
   [Sun, Tao; Cheng, Yutong; Wang, Su; Wang, Qian] Capital Med Univ, Beijing Anzhen Hosp, Div Cardiol, Beijing, Peoples R China.
   [Zhang, Jing; Zhang, HaiXia] Beijng Childrens Hosp, Shunyi Maternal & Childrens Hosp, Dept Ultrasound, Beijing, Peoples R China.
   [Krittanawong, Chayakrit] Baylor Coll Med, Sect Cardiol, Houston, TX 77030 USA.
   [El-Am, Edward] Indiana Univ Sch Med, Dept Med, Indianapolis, IN 46202 USA.
   [Abou Karam, Roukoz] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Cardiovasc Div, Boston, MA 02115 USA.
C3 Capital Medical University; Capital Medical University; Baylor College
   of Medicine; Indiana University System; Indiana University Bloomington;
   Harvard University; Harvard University Medical Affiliates; Beth Israel
   Deaconess Medical Center; Harvard Medical School
RP Ma, N (corresponding author), Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Dept Echocardiog, Beijing, Peoples R China.
EM maning_echo@163.com
RI Sun, Tao/HKO-1723-2023; Wang, Yong-Qiang/AAG-9444-2020; Abou-Karam,
   Roukoz/NFS-2432-2025
FU Natural Science Foundation of Beijing Municipality [7192062, 7202046]
FX This work was supported by Natural Science Foundation of Beijing
   Municipality; under Grant number 7192062 and 7202046.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Amra Babak, 2018, Oman Med J, V33, P184, DOI 10.5001/omj.2018.36
   Brant LCC, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.116.004199
   Çetin M, 2020, INT J CARDIOVAS IMAG, V36, P69, DOI 10.1007/s10554-019-01699-2
   Chedraui P, 2014, MATURITAS, V77, P370, DOI 10.1016/j.maturitas.2014.01.014
   Choi BJ, 2014, ARTERIOSCL THROM VAS, V34, P2473, DOI 10.1161/ATVBAHA.114.304445
   Cleuren ACA, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0131859
   De Bandt JP, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020610
   Ghazizadeh H, 2020, MOL BIOL REP, V47, P867, DOI 10.1007/s11033-019-05081-2
   Giallauria F, 2008, J CARDIOVASC MED, V9, P987, DOI 10.2459/JCM.0b013e32830b58d4
   Grandl G, 2018, SEMIN IMMUNOPATHOL, V40, P215, DOI 10.1007/s00281-017-0666-5
   Guarner V, 2015, INTERD T GERONT GERI, V40, P99, DOI 10.1159/000364934
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Irace C, 2013, EUR J CLIN INVEST, V43, P49, DOI 10.1111/eci.12016
   Jeon YK, 2011, ENDOCR J, V58, P87, DOI 10.1507/endocrj.K10E-297
   Khashchenko E, 2020, J CLIN MED, V9, DOI 10.3390/jcm9051399
   Kip KE, 2004, CIRCULATION, V109, P706, DOI 10.1161/01.CIR.0000115514.44135.A8
   Korcarz CE, 2014, SLEEP, V37, P1707, DOI 10.5665/sleep.4086
   Li J, 2012, MAYO CLIN PROC, V87, P968, DOI 10.1016/j.mayocp.2012.07.004
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   Nishimura S, 2008, J CLIN INVEST, V118, P710, DOI 10.1172/JCI33328
   Prasad M, 2017, HYPERTENSION, V69, P236, DOI 10.1161/HYPERTENSIONAHA.116.08436
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   Rubinshtein R, 2010, EUR HEART J, V31, P1142, DOI 10.1093/eurheartj/ehq010
   Safranow K, 2016, POSTEP HIG MED DOSW, V70, P56, DOI 10.5604/17322693.1194612
   Samsamshariat S, 2019, ADV BIOMED RES-INDIA, V8, DOI 10.4103/abr.abr_126_18
   Sara JDS, 2017, AM HEART J, V190, P1, DOI 10.1016/j.ahj.2017.02.035
   Shin Whan, 2019, J Menopausal Med, V25, P49, DOI 10.6118/jmm.2019.25.1.49
   Varghese JF, 2018, CURR CARDIOL REV, V14, P4, DOI 10.2174/1573403X13666171009112250
   Viegas C, 2019, AGING-US, V11, P4274, DOI 10.18632/aging.102046
   You TJ, 2004, J CLIN ENDOCR METAB, V89, P5517, DOI 10.1210/jc.2004-0480
NR 31
TC 2
Z9 2
U1 1
U2 4
PU AVES
PI SISLI
PA BUYUKDERE CAD 105-9, MECIDIYEKOY, SISLI, ISTANBUL 34394, TURKEY
SN 1016-5169
J9 TURK KARDIYOL DERN A
JI Turk Kardiyol. Dern. Ars.
PD JAN
PY 2022
VL 50
IS 1
BP 58
EP 66
DI 10.5543/tkda.2022.47443
PG 9
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA YE7XK
UT WOS:000741333800009
PM 35197234
OA Bronze
DA 2025-06-11
ER

PT J
AU Inoue, T
   Yoshida, K
   Sasaki, E
   Aizawa, K
   Kamioka, H
AF Inoue, Takuro
   Yoshida, Kazutaka
   Sasaki, Erika
   Aizawa, Koichi
   Kamioka, Hiroharu
TI Effects of lycopene intake on HDL-cholesterol and triglyceride levels: A
   systematic review with meta-analysis
SO JOURNAL OF FOOD SCIENCE
LA English
DT Review
ID DENSITY-LIPOPROTEIN CHOLESTEROL; CARDIOVASCULAR-DISEASE RISK; OXIDATIVE
   STRESS MARKERS; METABOLIC SYNDROME; TOMATO-JUICE; CAROTENOID
   CONCENTRATIONS; DIETARY SUPPLEMENTATION; MODERATELY OVERWEIGHT; LOWER
   PREVALENCE; PLASMA LYCOPENE
AB Lycopene is a lipophilic unsaturated carotenoid and has a very strong singlet oxygen-quenching ability. Increased serum or plasma lycopene levels have been reported to be associated with a lower risk of metabolic syndrome. We aimed to investigate the effects of lycopene intake on blood HDL-cholesterol (HCL-c) and triglyceride (TG) levels, which are metabolic syndrome biomarkers, by systematic review and meta-analyses of human interventional trials. We searched 15 databases and included studies that assessed the effects of oral lycopene intake on blood HDL-c and TG levels of participants >= 18 years of age. Three reviewers independently selected applicable studies, then assessed study qualities. Data were pooled as standardized mean difference (SMD) and analyzed by random-effects model. Heterogeneity was assessed by I-2 statistics. Meta-analysis including 12 trial arms (n = 781) revealed a significantly increased HDL-c level in the lycopene group compared with that in the control group (SMD = 0.33 [95% CI: 0.12, 0.54], p = 0.002) and moderate heterogeneity (I-2 = 45%). Most subgroup meta-analyses (restricted to study design, test food type, intake period, and participants' characteristics) showed similar results for HDL-c level. On the other hand, meta-analysis including 11 studies (n = 854) revealed no significant difference in TG level between the lycopene and control groups. Most studies which met eligibility criteria had moderate risk of bias. Funnel plots for HDL-c and TG suggested an absence of publication bias. In conclusion, this systematic review and meta-analyses suggested that lycopene intake significantly improved blood HDL-c levels but not TG levels.
C1 [Inoue, Takuro; Yoshida, Kazutaka; Sasaki, Erika; Aizawa, Koichi] KAGOME CO LTD, Innovat Div, Nat & Wellness Res Dept, 17 Nishitomiyama, Nasushiobara, Tochigi 3292762, Japan.
   [Inoue, Takuro; Kamioka, Hiroharu] Tokyo Univ Agr, Dept Ecol Symbiot Sci, Setagaya Ku, Tokyo, Japan.
C3 Kagome Co., Ltd.; Tokyo University of Agriculture
RP Inoue, T (corresponding author), KAGOME CO LTD, Innovat Div, Nat & Wellness Res Dept, 17 Nishitomiyama, Nasushiobara, Tochigi 3292762, Japan.
EM Takuro_Inoue@kagome.co.jp
FU KAGOME CO., LTD.
FX This research was funded by KAGOME CO., LTD.
CR Agarwal S, 1998, LIPIDS, V33, P981, DOI 10.1007/s11745-998-0295-6
   Aizawa K., 2018, Lycopene and Tomatoes in Human Nutrition and Health, P41, DOI DOI 10.1201/9781351110877-3
   Blum A, 2006, CLIN INVEST MED, V29, P298
   Böhm V, 1999, EUR J NUTR, V38, P118, DOI 10.1007/s003940050052
   Brown MJ, 2004, AM J CLIN NUTR, V80, P396, DOI 10.1093/ajcn/80.2.396
   Cheng HM, 2017, ATHEROSCLEROSIS, V257, P100, DOI 10.1016/j.atherosclerosis.2017.01.009
   Collins JK, 2004, NUTR J, V3, DOI 10.1186/1475-2891-3-15
   Cuevas-Ramos D, 2013, DIABET METAB SYND OB, V6, P263, DOI 10.2147/DMSO.S48858
   Delavar MA, 2009, ASIA PAC J CLIN NUTR, V18, P285
   Deplanque X, 2016, FOOD NUTR RES, V60, DOI 10.3402/fnr.v60.32537
   DERSIMONIAN R, 1986, CONTROL CLIN TRIALS, V7, P177, DOI 10.1016/0197-2456(86)90046-2
   Devaraj S, 2008, J AM COLL NUTR, V27, P267, DOI 10.1080/07315724.2008.10719699
   DI MASCIO P, 1989, ARCH BIOCHEM BIOPHYS, V274, P532, DOI 10.1016/0003-9861(89)90467-0
   dos Santos MC, 2018, NUTR J, V17, DOI 10.1186/s12937-018-0371-9
   Edwards Jayne E, 2003, BMC Fam Pract, V4, P18, DOI 10.1186/1471-2296-4-18
   Engelhard YN, 2006, AM HEART J, V151, DOI 10.1016/j.ahj.2005.05.008
   Esmaillzadeh A, 2006, AM J CLIN NUTR, V84, P1489, DOI 10.1093/ajcn/84.6.1489
   Essiarab F, 2014, ETHNIC DIS, V24, P207
   Ford ES, 2008, DIABETES CARE, V31, P1898, DOI 10.2337/dc08-0423
   FRIEDEWALD WT, 1972, CLIN CHEM, V18
   Furlan AD, 2015, SPINE, V40, P1660, DOI 10.1097/BRS.0000000000001061
   Gadgil MD, 2015, J NUTR, V145, P1211, DOI 10.3945/jn.114.207753
   Gajendragadkar PR, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0099070
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Gartner C, 1997, AM J CLIN NUTR, V66, P116
   Gasevic D, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-159
   Gregório BM, 2016, CURR PHARM DESIGN, V22, P859, DOI 10.2174/1381612822666151209152352
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Gupta AK, 2011, DIABETIC MED, V28, P941, DOI 10.1111/j.1464-5491.2011.03330.x
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Higgins JPT, 2002, STAT MED, V21, P1539, DOI 10.1002/sim.1186
   Kapoor MC, 2016, INDIAN J ANAESTH, V60, P626, DOI [10.4103/0019-5049.174802, 10.4103/0019-5049.190616]
   Kim JY, 2011, ATHEROSCLEROSIS, V215, P189, DOI 10.1016/j.atherosclerosis.2010.11.036
   Kiokias S, 2003, EUR J CLIN NUTR, V57, P1135, DOI 10.1038/sj.ejcn.1601655
   Lee JS, 2017, DIABETES CARE, V40, P529, DOI 10.2337/dc16-1958
   Liu J, 2014, BRIT J NUTR, V112, P2041, DOI 10.1017/S000711451400316X
   Macdonald G, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001930.pub3
   Maslov LN, 2019, J CLIN TRANSL ENDOCR, V15, P1, DOI 10.1016/j.jcte.2018.11.001
   McEneny J, 2013, J NUTR BIOCHEM, V24, P163, DOI 10.1016/j.jnutbio.2012.03.015
   Misra R, 2006, J OBSTET GYNAECOL RE, V32, P299, DOI 10.1111/j.1447-0756.2006.00410.x
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Olferiev A. V., 2004, Voprosy Pitaniya, V73, P19
   Palozza P, 2012, ANN NUTR METAB, V61, P126, DOI 10.1159/000342077
   Pan, 2007, CHIN J CLIN NUTR, V15, P43
   Paterson E, 2006, J NUTR, V136, P2849, DOI 10.1093/jn/136.11.2849
   Richelle M, 2002, J NUTR, V132, P404, DOI 10.1093/jn/132.3.404
   Ried K, 2011, MATURITAS, V68, P299, DOI 10.1016/j.maturitas.2010.11.018
   Rissanen TH, 2001, BRIT J NUTR, V85, P749, DOI 10.1079/BJN2001357
   Sabir AA, 2016, NIGER J CLIN PRACT, V19, P128, DOI 10.4103/1119-3077.173705
   Sakamoto H., 1994, Nippon Eiyo Shokuryo Gakkaishi = Journal of the Japanese Society of Nutrition and Food Science, V47, P93
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Salazar MR, 2013, J INTERN MED, V273, P595, DOI 10.1111/joim.12036
   Samaras A, 2014, FOOD CHEM TOXICOL, V69, P231, DOI 10.1016/j.fct.2014.03.029
   Sánchez-Rodríguez MA, 2010, ANN NUTR METAB, V56, P302, DOI 10.1159/000309601
   Schunemann H, 2013, GRADE HDB GRADING QU
   Senkus KE, 2019, ADV NUTR, V10, P19, DOI 10.1093/advances/nmy069
   Sesso HD, 2004, AM J CLIN NUTR, V79, P47
   Shea BJ, 2017, BMJ-BRIT MED J, V358, DOI 10.1136/bmj.j4008
   Shen YC, 2007, J AGR FOOD CHEM, V55, P6475, DOI 10.1021/jf070799z
   Sluijs I, 2009, J NUTR, V139, P987, DOI 10.3945/jn.108.101451
   Spahis S, 2017, ANTIOXID REDOX SIGN, V26, P445, DOI 10.1089/ars.2016.6756
   Steffen LM, 2014, BRIT J NUTR, V112, P1654, DOI 10.1017/S0007114514002633
   Story EN, 2010, ANNU REV FOOD SCI T, V1, P189, DOI 10.1146/annurev.food.102308.124120
   Sutherland WHF, 1999, CLIN NEPHROL, V52, P30
   Thies F, 2012, AM J CLIN NUTR, V95, P1013, DOI 10.3945/ajcn.111.026286
   Tsitsimpikou C, 2014, FOOD CHEM TOXICOL, V74, P9, DOI 10.1016/j.fct.2014.08.014
   Unlu NZ, 2007, BRIT J NUTR, V98, P140, DOI 10.1017/S0007114507685201
   Upritchard JE, 2000, DIABETES CARE, V23, P733, DOI 10.2337/diacare.23.6.733
   Wierzbicki AS, 2003, PHARMACOL THERAPEUT, V99, P95, DOI 10.1016/S0163-7258(03)00055-X
   Zeng YaoChi Zeng YaoChi, 2013, Acta Nutrimenta Sinica, V35, P268
NR 71
TC 13
Z9 13
U1 4
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-1147
EI 1750-3841
J9 J FOOD SCI
JI J. Food Sci.
PD AUG
PY 2021
VL 86
IS 8
BP 3285
EP 3302
DI 10.1111/1750-3841.15833
EA JUL 2021
PG 18
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA TZ2MV
UT WOS:000673801200001
PM 34268742
OA Bronze
DA 2025-06-11
ER

PT J
AU Sabbah, NA
   Rezk, NA
   Saad, MSS
AF Sabbah, Norhan Abdalla
   Rezk, Noha A.
   Saad, Mohamed S. S.
TI Relationship Between Heat Shock Protein Expression and Obesity With and
   Without Metabolic Syndrome
SO GENETIC TESTING AND MOLECULAR BIOMARKERS
LA English
DT Article
DE HSP70; HSP27; obesity; metabolic syndrome; diabetes mellitus
ID INSULIN SENSITIVITY; HOMEOSTASIS; GENE; HEAT-SHOCK-PROTEIN-70;
   INFLAMMATION; ASSOCIATION; CHOLESTEROL; RESISTANCE; KINASE
AB Background: Obesity is considered a chronic inflammatory disease in which the physiological mechanism responsible for reducing inflammation is weakened, prompting low-grade inflammation throughout the body. One of the key stress response systems that are dysregulated in obesity is the heat shock response, which is a critical defense mechanism that is activated in stressful conditions. Obesity is primary to metabolic syndrome (MetS) as it appears to lead to the increase in other MetS risk factors. Aim of the Study: We aimed to investigate the different expression levels of intracellular heat shock protein (iHSP) 70 and iHSP27 in obese patients with and without MetS and compare these levels to those of a lean control group. Patients and Methods: One hundred ten lean subjects were compared with 44 obese subjects without MetS and 56 obese subjects with MetS. HSP70 and HSP27 mRNA expression levels were measured by quantitative real-time polymerase chain reaction. Results: iHSP70 mRNA expression was significantly higher in obese subjects without MetS than in lean subjects (p = 0.04), whereas iHSP70 mRNA expression was significantly lower in obese subjects with MetS than in those without MetS (p = 0.02) as well as in those in the lean group (p = 0.03). iHSP27 mRNA expression was significantly lower in obese subjects with MetS than in those without MetS and in lean subjects (p = 0.037 and 0.031, respectively). Conclusion: We conclude that the intracellular expression levels of HSP70 and HSP27 may play an important role in the pathogenesis of MetS.
C1 [Sabbah, Norhan Abdalla; Rezk, Noha A.] Zagazig Univ, Fac Med, Dept Med Biochem, Zagazig 44512, Egypt.
   [Saad, Mohamed S. S.] Zagazig Univ, Fac Med, Dept Internal Med, Zagazig, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Egyptian Knowledge
   Bank (EKB); Zagazig University
RP Sabbah, NA (corresponding author), Zagazig Univ, Fac Med, Dept Med Biochem, Zagazig 44512, Egypt.
EM mazenmahmoud17@yahoo.co.uk
RI Sabbah, Norhan/AAG-1489-2019
OI Sabbah, Norhan/0000-0003-2281-0621; rezk, noha/0000-0002-5199-0134
CR Abubaker J, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0069217
   [Anonymous], 2014, Obesity and Overweight
   Arrigo AP, 2005, ANTIOXID REDOX SIGN, V7, P414, DOI 10.1089/ars.2005.7.414
   Atalay M, 2004, J APPL PHYSIOL, V97, P605, DOI 10.1152/japplphysiol.01183.2003
   Barness LA, 2007, AM J MED GENET A, V143A, P3016, DOI 10.1002/ajmg.a.32035
   Bastard JP, 2006, EUR CYTOKINE NETW, V17, P4
   Bonora E, 2000, DIABETES CARE, V23, P57, DOI 10.2337/diacare.23.1.57
   Bruce CR, 2003, DIABETES, V52, P2338, DOI 10.2337/diabetes.52.9.2338
   BUCOLO G, 1973, CLIN CHEM, V19, P476
   Chung J, 2008, P NATL ACAD SCI USA, V105, P1739, DOI 10.1073/pnas.0705799105
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cornier MA, 2008, ENDOCR REV, V29, P777, DOI 10.1210/er.2008-0024
   Deedwania P C, 2006, J Assoc Physicians India, V54, P797
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Garrido C, 1998, CANCER RES, V58, P5495
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Hooper PL, 2009, CELL STRESS CHAPERON, V14, P113, DOI 10.1007/s12192-008-0073-x
   Humphry RW, 2004, PREV VET MED, V65, P173, DOI 10.1016/j.prevetmed.2004.07.003
   Kalmar B, 2009, ADV DRUG DELIVER REV, V61, P310, DOI 10.1016/j.addr.2009.02.003
   Kaplan A., 1984, CLIN CHEM, P1257
   Kavanagh K, 2009, CELL STRESS CHAPERON, V14, P291, DOI 10.1007/s12192-008-0084-7
   Kondo T, 2011, CURR DIABETES REV, V7, P264, DOI 10.2174/157339911796397811
   Krause M, 2015, MEDIAT INFLAMM, V2015, DOI 10.1155/2015/249205
   Kurucz I, 2002, DIABETES, V51, P1102, DOI 10.2337/diabetes.51.4.1102
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   Madden LA, 2008, AMINO ACIDS, V34, P511, DOI 10.1007/s00726-007-0004-7
   Mohammadi F., 2018, J DIET SUPPL, P1
   Naito H.K., 1984, Clinical Chemistry, P1207
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Nosrati M, 2017, CURR CLIN PHARMACOL, V12, P113, DOI 10.2174/1574884712666170509162523
   Oliva K, 2013, J ENDOCRINOL, V218, P165, DOI 10.1530/JOE-13-0010
   Park KJ, 2003, J BIOL CHEM, V278, P35272, DOI 10.1074/jbc.M305095200
   RITOSSA P., 1962, RIV 1ST SIEROTERAPITAL, V37, P79
   Rossi A, 2010, J BIOL CHEM, V285, P13607, DOI 10.1074/jbc.M109.082693
   Solinas G, 2010, FASEB J, V24, P2596, DOI 10.1096/fj.09-151340
   Steffes M, 2005, CLIN CHEM, V51, P753, DOI 10.1373/clinchem.2004.042143
   Stygar D, 2019, CELL STRESS CHAPERON, V24, P427, DOI 10.1007/s12192-019-00976-2
   Tavallaie S, 2012, CLIN BIOCHEM, V45, P144, DOI 10.1016/j.clinbiochem.2011.09.022
   Tian X, 2016, BIOMED RES INT, V2016, DOI 10.1155/2016/4847874
   Tiss A, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-106
   Ward CW, 2009, BIOESSAYS, V31, P422, DOI 10.1002/bies.200800210
   Watt MJ, 2006, ENDOCRINOLOGY, V147, P2077, DOI 10.1210/en.2005-1074
   World Health Organization, 1995, WHO TECHN REP SER, V854, P321
   Zhang JL, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0722-8
   ZHANG YY, 1994, NATURE, V372, P425, DOI 10.1038/372425a0
NR 45
TC 9
Z9 9
U1 0
U2 8
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1945-0265
EI 1945-0257
J9 GENET TEST MOL BIOMA
JI Genet. Test. Mol. Biomark.
PD OCT 1
PY 2019
VL 23
IS 10
BP 737
EP 743
DI 10.1089/gtmb.2019.0062
EA SEP 2019
PG 7
WC Biochemistry & Molecular Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA JE4PU
UT WOS:000486500900001
PM 31517511
DA 2025-06-11
ER

PT J
AU Cho, MR
   Park, JK
   Choi, WJ
   Cho, AR
   Lee, YJ
AF Cho, Mi-Ra
   Park, Jin-Kyung
   Choi, Won-Jun
   Cho, A-Ra
   Lee, Yong-Jae
TI Serum ferritin level is positively associated with insulin resistance
   and metabolic syndrome in postmenopausal women: A nationwide population
   based study
SO MATURITAS
LA English
DT Article
DE Ferritin; Inflammation; Insulin resistance; Metabolic syndrome;
   Menopause
ID CORONARY HEART-DISEASE; OXIDATIVE STRESS; IRON OVERLOAD; RISK-FACTORS;
   ESTROGEN; INFLAMMATION; RECEPTOR; MARKERS; ALPHA
AB Objective: Serum ferritin, a marker of iron metabolism, has recently emerged as a biomarker of chronic low-grade inflammation. After menopause, there is a remarkable increase in insulin resistance (IR) and metabolic syndrome (MetS), which is increasingly being viewed as an inflammatory disease. Thus, we examined the associations of serum ferritin with insulin resistance and MetS in postmenopausal women.
   Methods: A nationwide cross-sectional study was conducted to examine the relationship between serum ferritin and IR and MetS in 2734 postmenopausal women using data from the 2010-2012 Korean National Health and Nutrition Examination Survey. The odds ratios (ORs) and 95% confidence intervals (CIs) for insulin resistance (HOMA-IR >= 75th percentile, 3.04) and MetS were calculated using multiple logistic regression analyses across serum ferritin quartiles (Q1, <= 36.25; Q2, 36.56-56.56; Q3, 56.57-85.98; and Q4 >= 85.99 ng/ml).
   Results: The mean values of most cardiometabolic variables tended to increase proportionally with serum ferritin quartiles. The proportion of women with IR and MetS significantly increased in accordance with serum ferritin quartiles. Compared to individuals in the lowest quartile, the ORs (95% CIs) in the highest quartile were 2.06 (1.23-3.45) for IR and 1.92 (1.44-2.55) for MetS after adjusting for age, cigarette smoking, alcohol intake, and regular exercise.
   Conclusion: Serum ferritin levels were positively and independently associated with IR and MetS in postmenopausal women. These findings suggest that serum ferritin level in postmenopausal women may help to identify the presence of IR and MetS.
C1 [Cho, Mi-Ra; Park, Jin-Kyung; Choi, Won-Jun; Cho, A-Ra; Lee, Yong-Jae] Yonsei Univ, Coll Med, Dept Family Med, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System
RP Lee, YJ (corresponding author), Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Family Med, 211 Eonju Ro, Seoul, South Korea.
EM ukyjhome@yuhs.ac
RI Lee, Yong Jae/GLR-4153-2022
OI Lee, Yong-Jae/0000-0002-6697-476X; CHO, A-RA/0000-0002-3645-2282; Choi,
   Won-Jun/0000-0002-8233-9272; Park, Jin-Kyung/0000-0002-3934-8632
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   de Leciñana MA, 2007, NEUROLOGY, V68, P33, DOI 10.1212/01.wnl.0000250238.69938.f5
   Atsma F, 2006, MENOPAUSE, V13, P265, DOI 10.1097/01.gme.0000218683.97338.ea
   BARRETTCONNOR E, 1991, JAMA-J AM MED ASSOC, V265, P1861, DOI 10.1001/jama.265.14.1861
   Chen L, 2017, J DIABETES COMPLICAT, V31, P364, DOI 10.1016/j.jdiacomp.2016.06.018
   Cheng HL, 2012, OBES REV, V13, P150, DOI 10.1111/j.1467-789X.2011.00938.x
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Esser N, 2014, Rev Med Liege, V69 Spec No, P57
   FEINSTEIN R, 1993, J BIOL CHEM, V268, P26055
   Fernández-Real JM, 2002, DIABETES, V51, P1000, DOI 10.2337/diabetes.51.4.1000
   González AS, 2006, EUR J CLIN NUTR, V60, P802, DOI 10.1038/sj.ejcn.1602384
   Graf E., J BIOL CHEM, V259
   Jehn M, 2004, DIABETES CARE, V27, P2422, DOI 10.2337/diacare.27.10.2422
   Jialal I, 2012, J CLIN ENDOCR METAB, V97, pE1844, DOI 10.1210/jc.2012-2498
   Koch RO, 2003, HISTOL HISTOPATHOL, V18, P1095, DOI 10.14670/HH-18.1095
   Lin N, 2012, DIABETES METAB, V38, P250, DOI 10.1016/j.diabet.2012.01.003
   Maldd K., 2013, ISRN INFLAMMATION, V2013
   Fernández-Real JM, 2014, LANCET DIABETES ENDO, V2, P513, DOI 10.1016/S2213-8587(13)70174-8
   Marchi R., 2017, ARCH ENDOCRINOL META
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Pham NM, 2013, METABOLISM, V62, P561, DOI 10.1016/j.metabol.2012.07.025
   Pelzer T, 2001, BIOCHEM BIOPH RES CO, V286, P1153, DOI 10.1006/bbrc.2001.5519
   PRIETO J, 1975, GASTROENTEROLOGY, V68, P525
   Robertson RP, 2006, FREE RADICAL BIO MED, V41, P177, DOI 10.1016/j.freeradbiomed.2005.04.030
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   van Lennep JER, 2002, CARDIOVASC RES, V53, P538, DOI 10.1016/S0008-6363(01)00388-1
NR 26
TC 26
Z9 27
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD SEP
PY 2017
VL 103
BP 3
EP 7
DI 10.1016/j.maturitas.2017.06.004
PG 5
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA FD6UR
UT WOS:000407663900002
PM 28778329
DA 2025-06-11
ER

PT J
AU Alemany, M
AF Alemany, Maria
TI Regulation of adipose tissue energy availability through blood flow
   control in the metabolic syndrome
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Review
DE White adipose tissue; Blood flow; Nitric oxide; Blood pressure;
   Metabolic syndrome; Obesity; Free radicals
ID NITRIC-OXIDE SYNTHASE; OBSTRUCTIVE SLEEP-APNEA; POLYUNSATURATED
   FATTY-ACIDS; DIET-INDUCED OBESITY; ENDOTHELIAL GROWTH-FACTOR; CIS-TRANS
   ISOMERIZATION; HUMAN SKELETAL-MUSCLE; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; HEART-RATE
AB Maintenance of blood flow rate is a critical factor for tissue oxygen and substrate supply. The potentially large mass of adipose tissue deeply influences the body distribution of blood flow. This is due to increased peripheral resistance in obesity and the role of this tissue as the ultimate destination of unused excess of dietary energy. However, adipose tissue cannot grow indefinitely, and the tissue must defend itself against the avalanche of nutrients provoking inordinate growth and inflammation. In the obese, large adipose tissue masses show lower blood flow, limiting the access of excess circulating substrates. Blood flow restriction is achieved by vasoconstriction, despite increased production of nitric oxide, the vasodilatation effects of which are overridden by catecholamines (and probably also by angiotensin II and endothelin). Decreased blood flow reduces the availability of oxygen, provoking massive glycolysis (hyperglycemic conditions), which results in the production of lactate, exported to the liver for processing. However, this produces local acidosis, which elicits the rapid dissociation of oxyhemoglobin, freeing bursts of oxygen in localized zones of the tissue. The excess of oxygen (and of nitric oxide) induces the production of reactive oxygen species, which deeply affect the endothelial, blood, and adipose cells, inducing oxidative and nitrosative damage and eliciting an increased immune response, which translates into inflammation. The result of the defense mechanism for adipose tissue, localized vasoconstriction, may thus help develop a more generalized pathologic response within the metabolic syndrome parameters, extending its effects to the whole body. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Alemany, Maria] Univ Barcelona, Fac Biol, Dept Nutr & Food Sci, E-08028 Barcelona, Spain.
C3 University of Barcelona
RP Alemany, M (corresponding author), Univ Barcelona, Fac Biol, Dept Nutr & Food Sci, E-08028 Barcelona, Spain.
EM malemany@ub.edu
RI Alemany, Maria/H-5224-2011
OI Alemany, Maria/0000-0002-9783-8293
FU Plan Nacional de Investigacion en Biomedicina of the Government of Spain
   [SAF2009-11739]
FX This work was supported by Grant SAF2009-11739 from the Plan Nacional de
   Investigacion en Biomedicina of the Government of Spain.
CR Ahmed N, 2005, DIABETES RES CLIN PR, V67, P3, DOI 10.1016/j.diabres.2004.09.004
   Ailhaud G, 2006, PROG LIPID RES, V45, P203, DOI 10.1016/j.plipres.2006.01.003
   Alemany M, NUTR RES RE IN PRESS
   Alemany M, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-74
   Alemany M, 2011, J CLIN ENDOCR METAB, V96, P66, DOI 10.1210/jc.2010-2541
   Alemany M, 2006, CURR NUTR FOOD SCI, V2, P141, DOI 10.2174/157340106776818817
   ALEXANDER J K, 1962, Cardiovasc Res Cent Bull, V1, P39
   Allessie MA, 2001, CIRCULATION, V103, P769
   Amra B, 2009, ANN ACAD MED SINGAP, V38, P461
   Andersson K., 2009, BRIT J PHARMACOL, V126, P1639
   Ardévol A, 1998, PFLUG ARCH EUR J PHY, V435, P454, DOI 10.1007/s004240050539
   Ardevol A, 1996, ARCH PHYSIOL BIOCHEM, V104, P337, DOI 10.1076/apab.104.3.337.12894
   Ardilouze JL, 2004, CIRCULATION, V109, P47, DOI 10.1161/01.CIR.0000105681.70455.73
   Azevedo L. C. P., 2006, Endocrine Metabolic & Immune Disorders-Drug Targets, V6, P159
   BALLARD K, 1971, ACTA PHYSIOL SCAND, V81, P246, DOI 10.1111/j.1748-1716.1971.tb04897.x
   BANGSBO J, 1993, J PHYSIOL-LONDON, V462, P115, DOI 10.1113/jphysiol.1993.sp019546
   Barton M, 2003, INT J BIOCHEM CELL B, V35, P826, DOI 10.1016/S1357-2725(02)00307-2
   Basili S, 2006, J AM COLL CARDIOL, V48, P2531, DOI 10.1016/j.jacc.2006.08.040
   Bender SB, 2007, DIABETES OBES METAB, V9, P688, DOI 10.1111/j.1463-1326.2006.00650.x
   Beuther DA, 2009, CLIN CHEST MED, V30, P479, DOI 10.1016/j.ccm.2009.05.002
   Blaak EE, 2004, DIABETOLOGIA, V47, P1462, DOI 10.1007/s00125-004-1471-y
   Blanco Miguel, 2005, Cerebrovasc Dis, V20 Suppl 2, P32, DOI 10.1159/000089355
   Bohr C, 1904, SKAND ARCH PHYSIOL, V16, P402, DOI 10.1111/j.1748-1716.1904.tb01382.x
   Borg R., 2009, CLIN LAB INT, V33, P14
   BREUER HWM, 1993, BRIT HEART J, V70, P144
   Cancello R, 2006, BJOG-INT J OBSTET GY, V113, P1141, DOI 10.1111/j.1471-0528.2006.01004.x
   CASADO J, 1990, J PHYSIOL-LONDON, V431, P557, DOI 10.1113/jphysiol.1990.sp018347
   Chaowalit N, 2006, ATHEROSCLEROSIS, V186, P354, DOI 10.1016/j.atherosclerosis.2005.08.004
   Chasens Eileen R, 2003, Biol Res Nurs, V5, P87, DOI 10.1177/1099800403257088
   Chen BY, 2006, BIOCHEM BIOPH RES CO, V341, P549, DOI 10.1016/j.bbrc.2006.01.004
   CHEN JJ, 1994, FREE RADICAL BIO MED, V17, P411, DOI 10.1016/0891-5849(94)90167-8
   Chevalier S, 2005, AM J CLIN NUTR, V82, P355, DOI 10.1093/ajcn/82.2.355
   Christoffersen C, 2003, ENDOCRINOLOGY, V144, P3483, DOI 10.1210/en.2003-0242
   Cicco G, 1999, CLIN HEMORHEOL MICRO, V21, P169
   Cinara L, 2006, CLIN HEMORHEOL MICRO, V35, P367
   Cinti S, 2005, PROSTAG LEUKOTR ESS, V73, P9, DOI 10.1016/j.plefa.2005.04.010
   Codoñer-Franch P, 2011, ATHEROSCLEROSIS, V215, P475, DOI 10.1016/j.atherosclerosis.2010.12.035
   CONCETTI A, 1976, J LAB CLIN MED, V87, P1057
   Crandall DL, 1997, MICROCIRCULATION-LON, V4, P211, DOI 10.3109/10739689709146786
   CRANDALL DL, 1990, FASEB J, V4, P141, DOI 10.1096/fasebj.4.2.2404816
   Dai Z, 2004, INT J CARDIOL, V96, P223, DOI 10.1016/j.ijcard.2003.07.012
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   Davy KP, 2004, AM J PHYSIOL-REG I, V286, pR803, DOI 10.1152/ajpregu.00707.2003
   de Kreutzenberg SV, 2003, EUR HEART J, V24, P1210, DOI 10.1016/S0195-668X(03)00206-9
   Dela Cruz CS, 2009, CLIN CHEST MED, V30, P509, DOI 10.1016/j.ccm.2009.06.001
   Dempsey JA, 2010, PHYSIOL REV, V90, P47, DOI 10.1152/physrev.00043.2008
   Dicker A, 1996, COMP BIOCHEM PHYS C, V113, P37, DOI 10.1016/0742-8413(95)02043-8
   DIGIROLAMO M, 1992, FASEB J, V6, P2405, DOI 10.1096/fasebj.6.7.1563593
   Dijkers PF, 2009, MOL BIOL CELL, V20, P4083, DOI 10.1091/mbc.E09-05-0362
   Duclos M, 2005, OBES RES, V13, P1157, DOI 10.1038/oby.2005.137
   Eitzman DT, 2000, ARTERIOSCL THROM VAS, V20, P1831, DOI 10.1161/01.ATV.20.7.1831
   Eriksson JW, 2007, FEBS LETT, V581, P3734, DOI 10.1016/j.febslet.2007.06.044
   Erlingsson S, 2009, METABOLISM, V58, P995, DOI 10.1016/j.metabol.2009.02.028
   Faustini-Fustini M, 1999, EUR J ENDOCRINOL, V140, P111, DOI 10.1530/eje.0.1400111
   Feelisch M, 2008, J BIOL CHEM, V283, P33927, DOI 10.1074/jbc.M806654200
   Félétou M, 2010, PFLUG ARCH EUR J PHY, V459, P941, DOI 10.1007/s00424-010-0812-6
   Fisher AB, 2002, CRIT CARE MED, V30, pS192, DOI 10.1097/00003246-200205001-00004
   Foz M, 2001, MED CLIN-BARCELONA, V116, P277, DOI 10.1016/S0025-7753(01)71796-4
   FREDHOLM BB, 1970, ACTA PHYSIOL SCAND, V79, P564, DOI 10.1111/j.1748-1716.1970.tb04759.x
   Freedland Eric S, 2004, Nutr Metab (Lond), V1, P12, DOI 10.1186/1743-7075-1-12
   Freeman BA, 2008, J BIOL CHEM, V283, P15515, DOI 10.1074/jbc.R800004200
   Frisbee JC, 2005, AM J PHYSIOL-REG I, V289, pR307, DOI 10.1152/ajpregu.00114.2005
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gallagher D, 2005, AM J CLIN NUTR, V81, P903, DOI 10.1093/ajcn/81.4.903
   Gao YJ, 2006, CARDIOVASC RES, V71, P363, DOI 10.1016/j.cardiores.2006.03.013
   GARNIER M, 1990, METABOLISM, V39, P794, DOI 10.1016/0026-0495(90)90121-R
   GEELEN MJH, 1984, FEBS LETT, V175, P8, DOI 10.1016/0014-5793(84)80558-X
   Gess B, 1997, AM J PHYSIOL-REG I, V273, pR905, DOI 10.1152/ajpregu.1997.273.3.R905
   Gil-Ortega M, 2010, ENDOCRINOLOGY, V151, P3299, DOI 10.1210/en.2009-1464
   Gladwin MT, 2004, FREE RADICAL BIO MED, V36, P707, DOI 10.1016/j.freeradbiomed.2003.11.032
   Gow AJ, 1999, P NATL ACAD SCI USA, V96, P9027, DOI 10.1073/pnas.96.16.9027
   Grant PJ, 2005, CURR MED RES OPIN, V21, pS5, DOI 10.1185/030079905X36431
   Gregor MF, 2007, J LIPID RES, V48, P1905, DOI 10.1194/jlr.R700007-JLR200
   Gruberg L, 2002, J AM COLL CARDIOL, V39, P578, DOI 10.1016/S0735-1097(01)01802-2
   GUSTAFSON AB, 1982, J CLIN ENDOCR METAB, V55, P703, DOI 10.1210/jcem-55-4-703
   Guzik TJ, 2007, J PHYSIOL PHARMACOL, V58, P591
   Guzik TJ, 2006, J PHYSIOL PHARMACOL, V57, P505
   Hadjipanayi E, 2010, J CONTROL RELEASE, V146, P309, DOI 10.1016/j.jconrel.2010.05.037
   HAGSTROM E, 1990, AM J PHYSIOL, V258, pE888, DOI 10.1152/ajpendo.1990.258.5.E888
   Hajer GR, 2008, EUR HEART J, V29, P2959, DOI 10.1093/eurheartj/ehn387
   Hanada A, 2003, J PHYSIOL-LONDON, V551, P635, DOI 10.1113/jphysiol.2003.044024
   HARRIS WS, 1967, J CLIN INVEST, V46, P1704, DOI 10.1172/JCI105661
   HENRIKSEN O, 1976, ACTA PHYSIOL SCAND, V98, P30, DOI 10.1111/j.1748-1716.1976.tb10299.x
   HILPERT P, 1963, AM J PHYSIOL, V205, P337, DOI 10.1152/ajplegacy.1963.205.2.337
   HJEMDAHL P, 1976, ACTA PHYSIOL SCAND, V97, P319, DOI 10.1111/j.1748-1716.1976.tb10269.x
   Hong J, 2009, NUTR J, V8, DOI 10.1186/1475-2891-8-11
   Hopps E, 2010, NUTR METAB CARDIOVAS, V20, P72, DOI 10.1016/j.numecd.2009.06.002
   Hosogai N, 2007, DIABETES, V56, P901, DOI 10.2337/db06-0911
   Iacobellis G, 2007, CURR PHARM DESIGN, V13, P2180
   Ichiki T, 2010, CIRC J, V74, P1300, DOI 10.1253/circj.CJ-10-0466
   Iiyori N, 2007, AM J RESP CRIT CARE, V175, P851, DOI 10.1164/rccm.200610-1527OC
   Ip MSM, 2000, AM J RESP CRIT CARE, V162, P2166, DOI 10.1164/ajrccm.162.6.2002126
   JAKICIC JM, 1995, INT J OBESITY, V19, P382
   Jansson PAE, 1998, EUR J CLIN INVEST, V28, P813
   Jebelovszki E, 2008, AM J PHYSIOL-HEART C, V294, pH2558, DOI 10.1152/ajpheart.01198.2007
   Kabagambe EK, 2008, CLIN CHEM, V54, P154, DOI 10.1373/clinchem.2007.095059
   Kapsimalls F, 2008, SLEEP MED, V9, P603, DOI 10.1016/j.sleep.2007.08.019
   Karpe F, 2002, DIABETES, V51, P2467, DOI 10.2337/diabetes.51.8.2467
   Karpe F, 2002, J PHYSIOL-LONDON, V540, P1087, DOI 10.1113/jphysiol.2001.013358
   Katakam PVG, 2006, AM J PHYSIOL-REG I, V290, pR145, DOI 10.1152/ajpregu.00405.2005
   Katan MB, 1997, J LIPID RES, V38, P2012
   Khanna D, 2007, J CARDIOVASC PHARM, V50, P692, DOI 10.1097/FJC.0b013e318158de08
   Kleinbongard P, 2006, BLOOD, V107, P2943, DOI 10.1182/blood-2005-10-3992
   Klusonová P, 2009, ENDOCRINOLOGY, V150, P4270, DOI 10.1210/en.2008-1493
   Knerr I, 2005, INT J OBESITY, V29, P275, DOI 10.1038/sj.ijo.0802885
   Koch R, 1999, Curr Hypertens Rep, V1, P127, DOI 10.1007/s11906-999-0006-9
   Korantzopoulos P, 2005, CARDIOLOGY, V104, P148, DOI 10.1159/000087636
   Korhonen Riku, 2005, Current Drug Targets - Inflammation and Allergy, V4, P471, DOI 10.2174/1568010054526359
   Kruse A, 2008, CONTRIB NEPHROL, V161, P247, DOI 10.1159/000130698
   Kunduzova O, 2008, FASEB J, V22, P4146, DOI 10.1096/fj.07-104018
   Langin D, 2011, CELL METAB, V14, P569, DOI 10.1016/j.cmet.2011.10.003
   LARKIN LM, 1994, AM J PHYSIOL, V266, pR749, DOI 10.1152/ajpregu.1994.266.3.R749
   Lavi S, 2008, HYPERTENSION, V51, P127, DOI 10.1161/HYPERTENSIONAHA.107.099986
   LEVIN BE, 1983, AM J PHYSIOL, V244, pR347, DOI 10.1152/ajpregu.1983.244.3.R347
   LITCHFIE.C, 1965, J AM OIL CHEM SOC, V42, P73, DOI 10.1007/BF02545031
   Loomis ED, 2005, J PHARMACOL EXP THER, V315, P1058, DOI 10.1124/jpet.105.091728
   Loot AE, 2009, J EXP MED, V206, P2889, DOI 10.1084/jem.20090449
   Lummis SCR, 2005, NATURE, V438, P248, DOI 10.1038/nature04130
   Lundberg JO, 2008, NAT REV DRUG DISCOV, V7, DOI [10.1038/nrd2466-c2, 10.1038/nrd2466]
   Maeda N, 2002, NAT MED, V8, P731, DOI 10.1038/nm724
   Malavazos AE, 2007, INT J CARDIOL, V121, P132, DOI 10.1016/j.ijcard.2006.08.061
   Maniscalco M, 2007, RESP PHYSIOL NEUROBI, V156, P370, DOI 10.1016/j.resp.2006.10.003
   Manodori AB, 2002, J LAB CLIN MED, V140, P161, DOI 10.1067/mlc.2002.126504
   Marcelin G, 2010, CURR OPIN PHARMACOL, V10, P588, DOI 10.1016/j.coph.2010.05.008
   Marchesi C, 2009, HYPERTENSION, V54, P1384, DOI 10.1161/HYPERTENSIONAHA.109.138305
   Marshall GD, 2000, ALLERGY ASTHMA PROC, V21, P241, DOI 10.2500/108854100778248917
   Matsubara M, 2002, EUR J ENDOCRINOL, V147, P173, DOI 10.1530/eje.0.1470173
   MATTSON FH, 1985, J LIPID RES, V26, P194
   Maury E, 2010, MOL CELL ENDOCRINOL, V314, P1, DOI 10.1016/j.mce.2009.07.031
   MCCORD JM, 1969, J BIOL CHEM, V244, P6049
   MCDANIEL HG, 1975, AM J PHYSIOL, V229, P1569, DOI 10.1152/ajplegacy.1975.229.6.1569
   Melanson EL, 2009, ANN NUTR METAB, V55, P229, DOI 10.1159/000229004
   MELILLO G, 1995, J EXP MED, V182, P1683, DOI 10.1084/jem.182.6.1683
   MESSERLI FH, 1982, LANCET, V1, P1165
   MESSERLI FH, 1983, AM J MED, V74, P808, DOI 10.1016/0002-9343(83)91071-9
   Micallef M, 2009, BRIT J NUTR, V102, P1370, DOI 10.1017/S0007114509382173
   Millet L., 1988, J APPL PHYSIOL, V85, P181
   Miyashita Y, 2007, DIABETES RES CLIN PR, V78, P51, DOI 10.1016/j.diabres.2007.02.021
   Moldovan L, 2004, HISTOCHEM CELL BIOL, V122, P395, DOI 10.1007/s00418-004-0676-y
   MORALES LM, 1994, BIOCHEM BIOPH RES CO, V199, P1151, DOI 10.1006/bbrc.1994.1351
   Mouren S, 1997, AM J PHYSIOL-HEART C, V272, pH67, DOI 10.1152/ajpheart.1997.272.1.H67
   Muñoz S, 2010, DIABETOLOGIA, V53, P2417, DOI 10.1007/s00125-010-1840-7
   Murphy MP, 2009, BIOCHEM J, V417, P1, DOI 10.1042/BJ20081386
   Nathan DM, 2008, DIABETES CARE, V31, P173, DOI [10.2337/dc08-9016, 10.2337/dc08-0545]
   Needleman M, 2011, CURR OPIN CARDIOL, V26, P40, DOI 10.1097/HCO.0b013e328341398e
   NegreSalvayre A, 1997, FASEB J, V11, P809, DOI 10.1096/fasebj.11.10.9271366
   Nichols GA, 2009, DIABETES CARE, V32, P1851, DOI 10.2337/dc09-0939
   Nikolaidis MG, 2009, ARCH BIOCHEM BIOPHYS, V490, P77, DOI 10.1016/j.abb.2009.08.015
   Olopade CO, 1997, CHEST, V111, P1500, DOI 10.1378/chest.111.6.1500
   Pagano C, 2008, NUTR METAB CARDIOVAS, V18, P189, DOI 10.1016/j.numecd.2006.05.009
   PALOU A, 1980, DIABETES METAB, V6, P271
   Papapetropoulos A, 1997, J CLIN INVEST, V100, P3131, DOI 10.1172/JCI119868
   Parish JM, 2004, MAYO CLIN PROC, V79, P1036, DOI 10.4065/79.8.1036
   Parks EJ, 1998, AM J CLIN NUTR, V68, P778, DOI 10.1093/ajcn/68.4.778
   Pasarica M, 2009, DIABETES, V58, P718, DOI 10.2337/db08-1098
   Podrez EA, 2007, NAT MED, V13, P1086, DOI 10.1038/nm1626
   Proell JM, 2002, J LIPID RES, V43, P2072, DOI 10.1194/jlr.M200284-JLR200
   Przedborski S, 2005, ANTIOXID REDOX SIGN, V7, P685, DOI 10.1089/ars.2005.7.685
   Qvisth V, 2007, AM J PHYSIOL-ENDOC M, V292, pE709, DOI 10.1152/ajpendo.00104.2006
   RADI R, 1991, J BIOL CHEM, V266, P4244
   Rajala MW, 2003, ENDOCRINOLOGY, V144, P3765, DOI 10.1210/en.2003-0580
   Redline S, 1998, CLIN CHEST MED, V19, P1, DOI 10.1016/S0272-5231(05)70428-7
   Regazzetti C, 2009, DIABETES, V58, P95, DOI 10.2337/db08-0457
   RICKETT GMW, 1990, DEVELOPMENT, V108, P331
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   RODE HN, 1982, BIOCHIM BIOPHYS ACTA, V688, P66, DOI 10.1016/0005-2736(82)90579-X
   Roscic M, 2006, BIOORGAN MED CHEM, V14, P4933, DOI 10.1016/j.bmc.2006.03.006
   ROSDAHL H, 1993, J PHYSIOL-LONDON, V471, P637, DOI 10.1113/jphysiol.1993.sp019920
   ROSELL S, 1975, NATURE, V253, P738, DOI 10.1038/253738a0
   Saint-Marc P, 2001, ENDOCRINOLOGY, V142, P487, DOI 10.1210/en.142.1.487
   Salmenniemi U, 2004, CIRCULATION, V110, P3842, DOI 10.1161/01.CIR.0000150391.38660.9B
   Sapolsky RM, 2000, ENDOCR REV, V21, P55, DOI 10.1210/er.21.1.55
   Satoh N, 2009, ENDOCR J, V56, P915, DOI 10.1507/endocrj.K09E-167
   Schauerte P, 2001, J CARDIOVASC ELECTR, V12, P592, DOI 10.1046/j.1540-8167.2001.00592.x
   Scheuer DA, 2010, EXP PHYSIOL, V95, P26, DOI 10.1113/expphysiol.2008.045971
   Schneider DJ, 2005, CORONARY ARTERY DIS, V16, P473, DOI 10.1097/00019501-200512000-00003
   SENAULT C, 1990, BIOCHIM BIOPHYS ACTA, V1023, P283, DOI 10.1016/0005-2736(90)90424-M
   SHAPIRO R, 1980, J BIOL CHEM, V255, P3120
   Shore SA, 2008, J ALLERGY CLIN IMMUN, V121, P1087, DOI 10.1016/j.jaci.2008.03.004
   Siervo M, 2011, J HYPERTENS, V29, P1515, DOI 10.1097/HJH.0b013e3283487806
   SIMPSON LO, 1988, MUSCLE NERVE, V11, P725, DOI 10.1002/mus.880110709
   Sivitz WI, 2007, J DIABETES COMPLICAT, V21, P149, DOI 10.1016/j.jdiacomp.2005.12.003
   SMITH U, 1980, EUR J CLIN INVEST, V10, P343, DOI 10.1111/j.1365-2362.1980.tb00042.x
   Solaini G, 2010, BBA-BIOENERGETICS, V1797, P1171, DOI 10.1016/j.bbabio.2010.02.011
   Steinhubl Steven R, 2005, Am J Cardiovasc Drugs, V5, P399, DOI 10.2165/00129784-200505060-00007
   Stepp DW, 2007, AM J PHYSIOL-HEART C, V293, pH2537, DOI 10.1152/ajpheart.01081.2006
   Stich V, 2000, J APPL PHYSIOL, V88, P1277, DOI 10.1152/jappl.2000.88.4.1277
   Subramanian S, 2008, ARTERIOSCL THROM VAS, V28, P685, DOI 10.1161/ATVBAHA.107.157685
   Summers LKM, 1996, CLIN SCI, V91, P679, DOI 10.1042/cs0910679
   Tamarat R, 2002, LAB INVEST, V82, P747, DOI 10.1097/01.LAB.0000017372.76297.EB
   Thatcher S, 2009, MOL CELL ENDOCRINOL, V302, P111, DOI 10.1016/j.mce.2009.01.019
   Thomas D, 2004, VOX SANG, V87, P70, DOI 10.1111/j.1741-6892.2004.00434.x
   THUBRIKAR MJ, 1995, ANN THORAC SURG, V59, P1594, DOI 10.1016/0003-4975(94)01037-D
   Torres J, 2000, FEBS LETT, V475, P263, DOI 10.1016/S0014-5793(00)01682-3
   Trayhurn P, 2008, BRIT J NUTR, V100, P227, DOI 10.1017/S0007114508971282
   Trostchansky A, 2008, FREE RADICAL BIO MED, V44, P1887, DOI 10.1016/j.freeradbiomed.2008.03.006
   Turhan H, 2004, AM HEART J, V148, P789, DOI 10.1016/j.ahj.2004.05.016
   Tuzcu EM, 2001, CIRCULATION, V103, P2705
   Ulker P, 2010, CLIN HEMORHEOL MICRO, V45, P169, DOI 10.3233/CH-2010-1293
   Umetsu DT, 2002, NAT IMMUNOL, V3, P715, DOI 10.1038/ni0802-715
   Vaarala O, 2008, DIABETES, V57, P2555, DOI 10.2337/db08-0331
   Vachharajani V, 2009, IUBMB LIFE, V61, P424, DOI 10.1002/iub.169
   van Dijk SJ, 2009, AM J CLIN NUTR, V90, P1656, DOI 10.3945/ajcn.2009.27792
   Van Guilder GP, 2006, OBESITY, V14, P2127, DOI 10.1038/oby.2006.248
   van Harmelen V, 2008, DIABETES, V57, P378, DOI 10.2337/db07-0893
   VANBLITTERSWIJK WJ, 1987, BIOCHEMISTRY-US, V26, P1746, DOI 10.1021/bi00380a038
   Vanderschueren D, 2004, ENDOCR REV, V25, P389, DOI 10.1210/er.2003-0003
   Vanninen E, 1996, CLIN PHYSIOL, V16, P209, DOI 10.1111/j.1475-097X.1996.tb00569.x
   Vgontzas AN, 2000, J CLIN ENDOCR METAB, V85, P1151, DOI 10.1210/jc.85.3.1151
   Vidgren HM, 1997, LIPIDS, V32, P697, DOI 10.1007/s11745-997-0089-x
   Villaret A, 2010, DIABETES, V59, P2755, DOI 10.2337/db10-0398
   Voros G, 2005, ENDOCRINOLOGY, V146, P4545, DOI 10.1210/en.2005-0532
   Wang CP, 2009, CLIN ENDOCRINOL, V70, P876, DOI 10.1111/j.1365-2265.2008.03411.x
   Wang H, 2008, AM J PHYSIOL-HEART C, V294, pH1473, DOI 10.1152/ajpheart.01249.2007
   Weber T, 2004, CIRCULATION, V109, P184, DOI 10.1161/01.CIR.0000105767.94169.E3
   WEST DB, 1987, AM J PHYSIOL, V253, pR228, DOI 10.1152/ajpregu.1987.253.2.R228
   White PJ, 2010, AM J PHYSIOL-ENDOC M, V299, pE868, DOI 10.1152/ajpendo.00510.2010
   Wiewiora M, 2007, OBES SURG, V17, P365, DOI 10.1007/s11695-007-9066-6
   Williams IL, 2002, INT J OBESITY, V26, P754, DOI 10.1038/sj.ijo.0801995
   Wiswedel I, 2010, FREE RADICAL RES, V44, P135, DOI 10.3109/10715760903352841
   Wolk R, 2003, HYPERTENSION, V42, P1067, DOI 10.1161/01.HYP.0000101686.98973.A3
   Wong DL, 2008, ANN NY ACAD SCI, V1148, P249, DOI 10.1196/annals.1410.048
   WOOD J, 1994, NEUROPHARMACOLOGY, V33, P1235, DOI 10.1016/0028-3908(94)90022-1
   Wray DW, 2009, AM J PHYSIOL-HEART C, V296, pH497, DOI 10.1152/ajpheart.01016.2008
   Wu ZF, 2009, ANTIOXID REDOX SIGN, V11, P1805, DOI [10.1089/ars.2009.2427, 10.1089/ARS.2009.2427]
   YANAGISAWA M, 1988, NATURE, V332, P411, DOI 10.1038/332411a0
   Ye J, 2009, INT J OBESITY, V33, P54, DOI 10.1038/ijo.2008.229
   Yin J, 2009, AM J PHYSIOL-ENDOC M, V296, pE333, DOI 10.1152/ajpendo.90760.2008
   You TJ, 2004, J CLIN ENDOCR METAB, V89, P5517, DOI 10.1210/jc.2004-0480
   Young ME, 2002, DIABETES, V51, P2587, DOI 10.2337/diabetes.51.8.2587
   Zambonin L, 2006, FREE RADICAL BIO MED, V40, P1549, DOI 10.1016/j.freeradbiomed.2005.12.021
   Zhou YT, 2000, P NATL ACAD SCI USA, V97, P1784, DOI 10.1073/pnas.97.4.1784
   Zhou YA, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-2
   Zielonka J, 2010, J BIOL CHEM, V285, P14210, DOI 10.1074/jbc.M110.110080
   Zimmermann MB, 2008, INT J OBESITY, V32, pS11, DOI 10.1038/ijo.2008.202
   Zou CC, 2007, INDIAN PEDIATR, V44, P275
NR 236
TC 26
Z9 28
U1 0
U2 18
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD MAY 15
PY 2012
VL 52
IS 10
BP 2108
EP 2119
DI 10.1016/j.freeradbiomed.2012.03.003
PG 12
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 960HH
UT WOS:000305378100006
PM 22542444
DA 2025-06-11
ER

PT J
AU Li, YR
   Hong, ZX
AF Li, Yaru
   Hong, Zhongxin
TI Dose-Response Relationship of Serum Uric Acid and Incidence of Metabolic
   Syndrome and Components: A 4-Year Prospective Cohort Study
SO INTERNATIONAL JOURNAL OF GERONTOLOGY
LA English
DT Article
DE cardiovascular disease; metabolic syndrome; retrospective studies
ID RISK; HEALTH; HYPERURICEMIA; PREVALENCE; NUTRITION; OBESITY; STRESS;
   ADULTS; IMPACT
AB Background: The incidence of metabolic syndrome (MetS) dramatically increases among middle-aged and elderly populations in China, which increases the risk of cardiovascular disease events and mortality.Methods: This survey was based on the China Health and Retirement Longitudinal Study baseline data in 2011 and follow-up data in 2015. 4,602 participants without MetS at baseline were included in the final analysis. The diagnosis of MetS was based on the Chinese guidelines. A multivariable logistic re-gression model was used to examine the association of serum uric acid quartiles, or continuous serum uric acid with the risk of incident MetS. Restricted cubic spline regression models were used to explore the dose-response relationship between serum uric acid levels and MetS incidence.Results: Serum uric acid quartiles were associated with an increased risk of MetS incidence (p for trend = 0.03), and the adjusted RRs (95% CI) were 1.17 (0.77, 1.75), 1.51 (1.01, 2.24) and 1.54 (1.01, 2.33) in quartiles 2-4, respectively. In particular, the association was more evident among women. The multi -variable-adjusted RR for 1 mg/dL in serum uric acid level was 1.17 (95% CI: 1.03, 1.34) for MetS incidence. In addition, the restricted cubic splines showed that higher serum uric acid levels were dose- response associated with increased MetS incidence risk (p for linear trend < 0.001).Conclusions: Our results suggested that higher serum uric acid levels were independently associated with a dose-response increased risk of MetS incidence. Copyright (c) 2023, Taiwan Society of Geriatric Emergency & Critical Care Medicine.
C1 [Li, Yaru; Hong, Zhongxin] Capital Med Univ, Beijing Friendship Hosp, Dept Nutr, 95 Yongan St, Beijing 100050, Peoples R China.
C3 Capital Medical University
RP Hong, ZX (corresponding author), Capital Med Univ, Beijing Friendship Hosp, Dept Nutr, 95 Yongan St, Beijing 100050, Peoples R China.
EM hongzhongxin@vip.sina.com
CR Ae R, 2020, HYPERTENS RES, V43, P354, DOI 10.1038/s41440-019-0346-z
   Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Biradar MI, 2020, INT J OBESITY, V44, P865, DOI 10.1038/s41366-019-0487-9
   Chen S, 2021, NUTR METAB, V18, DOI 10.1186/s12986-021-00584-x
   Choi YJ, 2014, LAB INVEST, V94, P1114, DOI 10.1038/labinvest.2014.98
   Cisse K, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2021-049496
   de Magalhaes ELG, 2021, NUTR METAB CARDIOVAS, V31, P2077, DOI 10.1016/j.numecd.2021.03.012
   Barbalho YGD, 2020, CLIN INTERV AGING, V15, P1691, DOI 10.2147/CIA.S252589
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Huang G, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-65605-w
   Huang G, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-01042-6
   Joint committee for guideline revision, 2018, J Geriatr Cardiol, V15, P1, DOI 10.11909/j.issn.1671-5411.2018.01.011
   Kim HJ, 2014, INT J CARDIOL, V174, P64, DOI 10.1016/j.ijcard.2014.03.163
   Li Y, 2021, GLOBAL HEALTH ACTION, V14, DOI 10.1080/16549716.2021.1874652
   Lima WG, 2015, BIOCHIMIE, V116, P17, DOI 10.1016/j.biochi.2015.06.025
   Liu FJ, 2021, DIABET METAB SYND OB, V14, P4691, DOI 10.2147/DMSO.S335558
   Liu M, 2014, INT J ENDOCRINOL, V2014, DOI 10.1155/2014/754678
   Liu SW, 2019, JAMA CARDIOL, V4, P342, DOI 10.1001/jamacardio.2019.0295
   Liu Y, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2019-035289
   Ma YC, 2006, J AM SOC NEPHROL, V17, P2937, DOI 10.1681/ASN.2006040368
   Piao W, 2022, BIOMED ENVIRON SCI, V35, P911, DOI 10.3967/bes2022.118
   Saito Y, 2021, J CARDIOL, V78, P51, DOI 10.1016/j.jjcc.2020.12.013
   Shirasawa T, 2020, BMC ENDOCR DISORD, V20, DOI 10.1186/s12902-020-0494-9
   Sun P, 2021, BMC PUBLIC HEALTH, V21, DOI 10.1186/s12889-021-10858-x
   Yao F, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124475
   Zhang S, 2021, NUTR METAB CARDIOVAS, V31, P1189, DOI 10.1016/j.numecd.2020.12.007
   Zhao YH, 2014, INT J EPIDEMIOL, V43, P61, DOI 10.1093/ije/dys203
   Zheng RJ, 2017, ANN CLIN LAB SCI, V47, P586
NR 29
TC 0
Z9 0
U1 2
U2 5
PU TAIWAN SOC GERIATRIC EMERGENCY & CRITICAL CARE MEDICINE-TSGECM
PI TAIPEI
PA 12F-14, NO 42, SEC 1, MINSHENG E RD, ZHONGSHAN DIST, TAIPEI, 104, TAIWAN
SN 1873-9598
EI 1873-958X
J9 INT J GERONTOL
JI Int. J. Gerontol.
PD OCT
PY 2023
VL 17
IS 4
BP 263
EP 268
DI 10.6890/IJGE.202310_17(4).0010
PG 6
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA W5EY1
UT WOS:001091868400011
DA 2025-06-11
ER

PT J
AU Zhou, X
   Fouda, S
   Zeng, XY
   Li, DL
   Zhang, K
   Xu, J
   Ye, JM
AF Zhou, Xiu
   Fouda, Sherouk
   Zeng, Xiao-Yi
   Li, Dongli
   Zhang, Kun
   Xu, Jun
   Ye, Ji-Ming
TI Characterization of the Therapeutic Profile of Albiflorin for the
   Metabolic Syndrome
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE albiflorin; metabolic syndrome; type 2 diabetes; non-alcoholic
   steatohepatitis; energy expenditure; physical activity
ID ACTIVATED PROTEIN-KINASE; ADENOSINE A(1) RECEPTOR; INDUCED
   INSULIN-RESISTANCE; FATTY LIVER-DISEASE; GLUCOSE-UPTAKE;
   DIETARY-CHOLESTEROL; PAEONIFLORIN; MUSCLE; RADIX; MICE
AB Albiflorin (AF) is a small molecule (MW 481) isolated from Paeoniae radix, a plant used as a remedy for various conditions with pathogenesis shared by metabolic diseases. Reported here is our characterization of its therapeutic profiles in three mouse models with distinctive pathological features of metabolic syndrome (MetS). Our results firstly showed that AF alleviated high fat (HF) induced obesity and associated glucose intolerance, suggesting its therapeutic efficacy for MetS. In the type 2 diabetes (T2D) model induced by a combination of HF and low doses of streptozotocin, AF lowered hyperglycaemia and improved insulin- stimulated glucose disposal. In the non-alcoholic steatohepatitis-like model resulting from a HF and high cholesterol (HF-HC) diet, AF reversed the increased liver triglyceride and cholesterol, plasma aspartate aminotransferase, and liver TNFa mRNA levels. Consistent with its effect in promoting glucose disposal in HF-fed mice, AF stimulated glucose uptake and GLUT4 translocation to the plasma membrane in L6 myotubes. However, these effects were unlikely to be associated with activation of insulin, AMPK, ER, or cellular stress signalling cascades. Further studies revealed that AF increased the whole-body energy expenditure and physical activity. Taken together, our findings indicate that AF exerts a therapeutic potential for MetS and related diseases possibly by promoting physical activity associated whole-body energy expenditure and glucose uptake in muscle. These effects are possibly mediated by a new mechanism distinct from other therapeutics derived from Chinese medicine.
C1 [Zhou, Xiu; Li, Dongli; Zhang, Kun; Xu, Jun; Ye, Ji-Ming] Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen, Peoples R China.
   [Zhou, Xiu; Fouda, Sherouk; Zeng, Xiao-Yi; Ye, Ji-Ming] RMIT Univ, Sch Hlth & Biomed Sci, Melbourne, Vic, Australia.
   [Zhou, Xiu; Zhang, Kun] Guangdong Univ Technol, Sch Biomed & Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China.
C3 Wuyi University; Royal Melbourne Institute of Technology (RMIT);
   Guangdong University of Technology
RP Zhou, X; Ye, JM (corresponding author), Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen, Peoples R China.; Zhou, X; Ye, JM (corresponding author), RMIT Univ, Sch Hlth & Biomed Sci, Melbourne, Vic, Australia.; Zhou, X (corresponding author), Guangdong Univ Technol, Sch Biomed & Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China.
EM zhou.xiu@hotmail.com; jiming.ye@rmit.edu.au
RI ZHOU, XIU/AAX-5312-2020; Zhang, Kun/S-5005-2019; Fouda,
   Sherouk/AAF-5823-2020
OI Fouda, Dr Sherouk/0000-0001-8227-4571
FU National Natural Science Foundation of China [535921]; Jiangmen Program
   for Innovative Research Team (China) [81870608];  [2018630100180019806]
FX This work was supported by NHMC Program Grant of Australia (535921),
   National Natural Science Foundation of China (81870608) and Jiangmen
   Program for Innovative Research Team (China) (2018630100180019806).
CR An JJ, 2015, CELL METAB, V22, P175, DOI 10.1016/j.cmet.2015.05.008
   Asgharpour A, 2016, J HEPATOL, V65, P579, DOI 10.1016/j.jhep.2016.05.005
   BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911
   Cartee G, 2015, DIABETOLOGIA, V58, P19, DOI 10.1007/s00125-014-3395-5
   Chan SMH, 2013, DIABETES, V62, P2095, DOI 10.2337/db12-1397
   Chang Y, 2009, J ETHNOPHARMACOL, V121, P43, DOI 10.1016/j.jep.2008.09.028
   Ciccarelli R, 2007, MOL PHARMACOL, V71, P1369, DOI 10.1124/mol.106.031617
   Cleasby ME, 2004, DIABETES, V53, P3258, DOI 10.2337/diabetes.53.12.3258
   Cohen JC, 2011, SCIENCE, V332, P1519, DOI 10.1126/science.1204265
   DeFronzo RA, 2009, DIABETES CARE, V32, pS157, DOI 10.2337/dc09-S302
   Diehl AM, 2017, NEW ENGL J MED, V377, P2063, DOI 10.1056/NEJMra1503519
   Eckel RH, 2010, LANCET, V375, P181, DOI 10.1016/S0140-6736(09)61794-3
   Friedman SL, 2018, NAT MED, V24, P908, DOI 10.1038/s41591-018-0104-9
   Hegarty BD, 2009, ACTA PHYSIOL, V196, P129, DOI 10.1111/j.1748-1716.2009.01968.x
   Hoehn KL, 2008, CELL METAB, V7, P421, DOI 10.1016/j.cmet.2008.04.005
   Hsu FL, 1997, PLANTA MED, V63, P323, DOI 10.1055/s-2006-957692
   Ioannou GN, 2016, TRENDS ENDOCRIN MET, V27, P84, DOI 10.1016/j.tem.2015.11.008
   Jiang DX, 2011, J ETHNOPHARMACOL, V137, P914, DOI 10.1016/j.jep.2011.07.020
   Juan YC, 2010, PHYTOMEDICINE, V17, P626, DOI 10.1016/j.phymed.2009.12.007
   Kim ID, 2010, ARCH PHARM RES, V33, P959, DOI 10.1007/s12272-010-0620-8
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Lai CW, 1998, LIFE SCI, V62, P1591, DOI 10.1016/S0024-3205(98)00112-X
   Lau CH, 2007, PHYTOMEDICINE, V14, P778, DOI 10.1016/j.phymed.2007.01.007
   Lee YS, 2006, DIABETES, V55, P2256, DOI 10.2337/db06-0006
   Lemmich J, 1996, PHYTOCHEMISTRY, V41, P1337, DOI 10.1016/0031-9422(95)00793-8
   Li Q, 2014, AM J PHYSIOL-ENDOC M, V307, pE209, DOI 10.1152/ajpendo.00045.2014
   Li SP, 2016, J NUTR BIOCHEM, V27, P96, DOI 10.1016/j.jnutbio.2015.08.021
   Li YF, 2011, J ASIAN NAT PROD RES, V13, P117, DOI 10.1080/10286020.2010.546353
   Migita H, 2008, J NEUROSCI RES, V86, P2820, DOI 10.1002/jnr.21742
   Morinaga O, 2013, PHYTOCHEM ANALYSIS, V24, P124, DOI 10.1002/pca.2389
   Qiu BY, 2010, DIABETES, V59, P256, DOI 10.2337/db09-0223
   Ren LP, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030816
   Robinson AJ, 2001, EUR J PHARMACOL, V413, P151, DOI 10.1016/S0014-2999(01)00761-0
   Rodrigues TM, 2014, NEUROPHARMACOLOGY, V79, P389, DOI 10.1016/j.neuropharm.2013.12.010
   Samuel VT, 2012, CELL, V148, P852, DOI 10.1016/j.cell.2012.02.017
   Sato M, 2018, BIOCHEM PHARMACOL, V148, P27, DOI 10.1016/j.bcp.2017.11.016
   Savard C, 2013, HEPATOLOGY, V57, P81, DOI 10.1002/hep.25789
   Scabia G, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-19886-x
   Tan MJ, 2008, CHEM BIOL, V15, P263, DOI 10.1016/j.chembiol.2008.01.013
   Tang LM, 2003, PLANTA MED, V69, P332, DOI 10.1055/s-2003-38878
   Turner N, 2008, DIABETES, V57, P1414, DOI 10.2337/db07-1552
   Turner N, 2007, DIABETES, V56, P2085, DOI 10.2337/db07-0093
   Turner N, 2016, TRENDS PHARMACOL SCI, V37, P379, DOI 10.1016/j.tips.2016.01.007
   Wang YL, 2016, J ETHNOPHARMACOL, V179, P9, DOI 10.1016/j.jep.2015.12.029
   Wild S, 2004, DIABETES CARE, V27, P1047, DOI 10.2337/diacare.27.5.1047
   Witczak CA, 2007, DIABETES, V56, P1403, DOI 10.2337/db06-1230
   Xie KQ, 2009, ACTA PHARMACOL SIN, V30, P889, DOI 10.1038/aps.2009.80
   Xu WZ, 2011, ASIAN PAC J CANCER P, V12, P2031
   YAMASAKI K, 1976, TETRAHEDRON LETT, P3965
   Yang HO, 2004, FITOTERAPIA, V75, P45, DOI 10.1016/j.fitote.2003.08.016
   Ye JM, 2011, BRIT J PHARMACOL, V163, P556, DOI 10.1111/j.1476-5381.2011.01240.x
   Younossi Z, 2018, NAT REV GASTRO HEPAT, V15, P11, DOI 10.1038/nrgastro.2017.109
   Zeng XY, 2015, BRIT J PHARMACOL, V172, P4303, DOI 10.1111/bph.13209
   Zeng XY, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0042115
   Zeng XY, 2012, BIOCHEM PHARMACOL, V84, P830, DOI 10.1016/j.bcp.2012.07.003
   Zhang P, 2009, AM J CHINESE MED, V37, P295, DOI 10.1142/S0192415X09006850
NR 56
TC 16
Z9 17
U1 0
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD OCT 11
PY 2019
VL 10
AR 1151
DI 10.3389/fphar.2019.01151
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA JO4BV
UT WOS:000497525600001
PM 31680948
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Afrand, M
   Bashardoost, N
   Sheikhha, MH
   Afkhami-Ardekani, M
AF Afrand, Mohammadhosain
   Bashardoost, Nasrollah
   Sheikhha, Mohammad Hasan
   Afkhami-Ardekani, Mohammad
TI Association between Glutathione S-Transferase GSTM1-T1 and P1
   Polymorphisms with Metabolic Syndrome in Zoroastrians in Yazd, Iran
SO IRANIAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
DE Glutathione S-transferase; Genetic polymorphism; Metabolic syndrome;
   Ethnic group; Iran
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; SUPERGENE FAMILY; GSTT1;
   CONTRIBUTES; OBESITY; CANCER; MEN
AB Background: The aim of this study was to assess the possible association between genetic polymorphisms of the glutathione S-transferase (GST) gene family and the risk of the development of metabolic syndrome (MS) in Zoroastrian females in Yazd, Iran.
   Methods: In this case-control study, GSTM1, T1, and P1 polymorphisms were genotyped in 51 randomly selected MS patients and 50 randomly selected healthy controls on February 2014 among Zoroastrian females whose ages ranged from 40 to 70 yr. DNA was extracted from peripheral blood. Data were analyzed with SPSS version 17.
   Results: We observed a significant association of GSTP1-I/V (Isoleucine/Valine) allele and GSTP1-V/V (Valine / Valine) allele with MS (P = 0.047 and P = 0.044, respectively). The combined analysis of the two genotypes, the present genotype of GSTT1, I/V and V/V alleles of GSTP1 genotype demonstrated a decrease in the risk of acquiring MS (OR = 0.246, P = 0.031). The null genotype of GSTM1, I/V, and V/V alleles of the GSTP1 genotype showed a lower risk in double combinations (OR = 0.15, P = 0.028 and OR = 0.13, P = 0.013, respectively). The combinations of the GSTM1 null genotypes and GSTT1 present genotypes and the GSTP1 I/V and V/V alleles together were associated with decreased risk of having MS in triple combinations (OR = 0.071, P = 0.039 and OR = 0.065, P = 0.022, respectively).
   Conclusion: GSTP1-I/V and V/V alleles, alone or in association with GSTM1 null and GSTT1 present genotypes, are related with decreased susceptibility to the development of MS in Zoroastrian females.
C1 [Afrand, Mohammadhosain] Islamic Azad Univ, Yazd Branch, Ali Ebne Abitaleb Fac Med, Med Sci Assoc, Yazd, Iran.
   [Bashardoost, Nasrollah] Islamic Azad Univ, Yazd Branch, Ali Ebne Abitaleb Fac Med, Dept Biostat & Epidemiol, Yazd, Iran.
   [Sheikhha, Mohammad Hasan] Shahid Sadoughi Univ Med Sci, Yazd Diabet Res Ctr, Dept Med Genet, Yazd, Iran.
   [Afkhami-Ardekani, Mohammad] Shahid Sadoughi Univ Med Sci, Yazd Diabet Res Ctr, Dept Endocrinol, Yazd, Iran.
C3 Islamic Azad University; Islamic Azad University; Shahid Sadoughi
   University of Medical Sciences; Shahid Sadoughi University of Medical
   Sciences
RP Afrand, M (corresponding author), Islamic Azad Univ, Yazd Branch, Ali Ebne Abitaleb Fac Med, Med Sci Assoc, Yazd, Iran.
EM Afrand@iauyazd.ac.ir
RI Afkhami-ardakani, Mohammad/AAP-9044-2021; Afrand,
   Mohammadhosain/ABD-7176-2020; Afrand, Mohammadhosain/G-2262-2014;
   Sheikhha, Mohammad Hasan/Q-7643-2017
OI Afrand, Mohammadhosain/0000-0003-3226-8119; Sheikhha, Mohammad
   Hasan/0000-0002-3734-8970
CR Afrand Mohammadhosain, 2015, Indian J Endocrinol Metab, V19, P124, DOI 10.4103/2230-8210.146867
   Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
   Amer MA, 2011, GENET MOL RES, V10, P3722, DOI 10.4238/2011.October.31.14
   Azizi F, 2010, ARCH IRAN MED, V13, P243
   Bailey LR, 1998, CANCER RES, V58, P65
   Baynes JW, 1999, DIABETES, V48, P1, DOI 10.2337/diabetes.48.1.1
   Boyce Mary., 1996, HIST ZOROASTRIANISM
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Doney ASF, 2005, CIRCULATION, V111, P2927, DOI 10.1161/CIRCULATIONAHA.104.509224
   Eriksson JW, 2007, FEBS LETT, V581, P3734, DOI 10.1016/j.febslet.2007.06.044
   Evans JL, 2003, DIABETES, V52, P1, DOI 10.2337/diabetes.52.1.1
   Farjadian S, 2011, HUM HERED, V72, P73, DOI 10.1159/000330166
   Fridlyand LE, 2006, DIABETES OBES METAB, V8, P136, DOI 10.1111/j.1463-1326.2005.00496.x
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   GALLOU G, 1993, CLIN CHIM ACTA, V214, P227, DOI 10.1016/0009-8981(93)90114-J
   Giugliano D, 2008, AM J CLIN NUTR, V87, p217S, DOI 10.1093/ajcn/87.1.217S
   Hayes JD, 1995, CRIT REV BIOCHEM MOL, V30, P445, DOI 10.3109/10409239509083491
   HAYES JD, 1995, FREE RADICAL RES, V22, P193, DOI 10.3109/10715769509147539
   Hori M, 2007, PHARMACOGENOMICS, V8, P1307, DOI 10.2217/14622416.8.10.1307
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Jang YS, 2001, AM J CLIN NUTR, V73, P68
   Khalilzadeh Saeedhossein, 2015, Electron Physician, V7, P998, DOI 10.14661/2015.998-1004
   Ko Y, 2000, PHARMACOGENETICS, V10, P271, DOI 10.1097/00008571-200004000-00009
   Kuzuya M, 2008, AM J CLIN NUTR, V87, P1939, DOI 10.1093/ajcn/87.6.1939
   Lear JT, 1996, CARCINOGENESIS, V17, P1891, DOI 10.1093/carcin/17.9.1891
   Lee YS, 2008, MOL ENDOCRINOL, V22, P2176, DOI 10.1210/me.2008-0023
   MANNERVIK B, 1992, BIOCHEM J, V282, P305, DOI 10.1042/bj2820305
   Mannervik B, 1985, Adv Enzymol Relat Areas Mol Biol, V57, P357
   Palmieri VO, 2006, J NUTR, V136, P3022, DOI 10.1093/jn/136.12.3022
   Park YM, 2010, PSYCHIAT INVEST, V7, P147, DOI 10.4306/pi.2010.7.2.147
   Roth MJ, 2000, CANCER LETT, V156, P73, DOI 10.1016/S0304-3835(00)00442-0
   Strange R C, 1999, IARC Sci Publ, P231
   Yalin S, 2007, CELL BIOCHEM FUNCT, V25, P509, DOI 10.1002/cbf.1339
NR 34
TC 9
Z9 10
U1 0
U2 1
PU IRANIAN SCIENTIFIC SOCIETY MEDICAL ENTOMOLOGY
PI TEHRAN
PA SCHOOL PUBLIC HEALTH & INST HEALTH RESEARCH, TEHRAN UNIV MEDICAL
   SCIENCES, P O BOX  6446-14155, TEHRAN, 00000, IRAN
SN 2251-6085
EI 2251-6093
J9 IRAN J PUBLIC HEALTH
JI Iran J. Public Health
PD MAY
PY 2015
VL 44
IS 5
BP 673
EP 682
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA CJ9SU
UT WOS:000355843800009
PM 26284209
DA 2025-06-11
ER

PT J
AU Cox, CL
   Stanhope, KL
   Schwarz, JM
   Graham, JL
   Hatcher, B
   Griffen, SC
   Bremer, AA
   Berglund, L
   McGahan, JP
   Keim, NL
   Havel, PJ
AF Cox, Chad L.
   Stanhope, Kimber L.
   Schwarz, Jean Marc
   Graham, James L.
   Hatcher, Bonnie
   Griffen, Steven C.
   Bremer, Andrew A.
   Berglund, Lars
   McGahan, John P.
   Keim, Nancy L.
   Havel, Peter J.
TI Consumption of fructose- but not glucose-sweetened beverages for 10
   weeks increases circulating concentrations of uric acid, retinol binding
   protein-4, and gamma-glutamyl transferase activity in overweight/obese
   humans
SO NUTRITION & METABOLISM
LA English
DT Article
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; VISCERAL ADIPOSITY; DIETARY
   FRUCTOSE; OXIDATIVE STRESS; LIVER; INFLAMMATION; OBESITY; LIPIDS;
   RETINOL-BINDING-PROTEIN-4
AB Background: Prospective studies in humans examining the effects of fructose consumption on biological markers associated with the development of metabolic syndrome are lacking. Therefore we investigated the relative effects of 10 wks of fructose or glucose consumption on plasma uric acid and RBP-4 concentrations, as well as liver enzyme (AST, ALT, and GGT) activities in men and women.
   Methods: As part of a parallel arm study, older (age 40-72), overweight and obese male and female subjects (BMI 25-35 kg/m(2)) consumed glucose- or fructose-sweetened beverages providing 25% of energy requirements for 10 wks. Fasting and 24-h blood collections were performed at baseline and following 10 wks of intervention and plasma concentrations of uric acid, RBP-4 and liver enzyme activities were measured.
   Results: Consumption of fructose, but not glucose, led to significant increases of 24-h uric acid profiles (P < 0.0001) and RBP-4 concentrations (P = 0.012), as well as plasma GGT activity (P = 0.04). Fasting plasma uric acid concentrations increased in both groups; however, the response was significantly greater in subjects consuming fructose (P = 0.002 for effect of sugar). Within the fructose group male subjects exhibited larger increases of RBP-4 levels than women (P = 0.024).
   Conclusions: These findings suggest that consumption of fructose at 25% of energy requirements for 10 wks, compared with isocaloric consumption of glucose, may contribute to the development of components of the metabolic syndrome by increasing circulating uric acid, GGT activity, suggesting alteration of hepatic function, and the production of RBP-4.
C1 [Stanhope, Kimber L.; Graham, James L.; Havel, Peter J.] Univ Calif Davis, Sch Vet Med, Dept Mol Biosci, Davis, CA 95616 USA.
   [Cox, Chad L.; Stanhope, Kimber L.; Graham, James L.; Hatcher, Bonnie; Keim, Nancy L.; Havel, Peter J.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Schwarz, Jean Marc] Touro Univ, Dept Basic Sci, Coll Osteopath Med, Vallejo, CA 94592 USA.
   [Griffen, Steven C.; Berglund, Lars] UCD Sch Med, Dept Internal Med, Sacramento, CA 95817 USA.
   [Bremer, Andrew A.] Vanderbilt Univ, Sch Med, Dept Pediat, Nashville, TN 37232 USA.
   [Keim, Nancy L.] USDA, Western Human Nutr Res Ctr, Davis, CA 95616 USA.
   [McGahan, John P.] UCD Med Ctr, Dept Radiol, Sacramento, CA 95817 USA.
C3 University of California System; University of California Davis;
   University of California System; University of California Davis; Touro
   University California; Vanderbilt University; United States Department
   of Agriculture (USDA)
RP Havel, PJ (corresponding author), Univ Calif Davis, Sch Vet Med, Dept Mol Biosci, 1 Shields Ave, Davis, CA 95616 USA.
EM pjhavel@ucdavis.edu
RI Havel, Peter/AFU-9329-2022
OI Berglund, Lars/0000-0001-6705-1791; Havel, Peter/0000-0003-3652-8301;
   Graham, James/0000-0001-6507-8149
FU NIH grant [RO1 HL-075675, HL-091333, AT-003545, DK-097307]; National
   Center for Research Resources (NCRR) [UL1 RR024146]; National Institutes
   of Health (NIH); NIH Roadmap for Medical Research; USDA-ARS [CRIS
   5306-51530-016-00D]
FX The authors thank Marinelle Nunez, Brandi Bair, Rebecca Stewart, Sara
   Wuehler, Barbara Gale, Artem Dyachenko and Patrick Lam for their
   excellent technical support and Nicole Mullen and the nursing staff at
   the CCRC for their dedicated nursing support. We also thank Janet
   Peerson for expert advice on the statistical analysis of the data. This
   research was supported with funding from NIH grant RO1 HL-075675. The
   project also received support from Grant Number UL1 RR024146 from the
   National Center for Research Resources (NCRR), a component of the
   National Institutes of Health (NIH), and NIH Roadmap for Medical
   Research. Dr. Havel's laboratory also receives support from NIH grants
   HL-091333, AT-003545, and DK-097307. Dr. Keim's research is supported by
   intramural USDA-ARS CRIS 5306-51530-016-00D.
CR Afzali A, 2010, HEPATOLOGY, V52, P578, DOI 10.1002/hep.23717
   Al-Daghri NM, 2008, DIABETES-METAB RES, V24, P52, DOI 10.1002/dmrr.763
   Bonora E, 2008, NUTR METAB CARDIOVAS, V18, P624, DOI 10.1016/j.numecd.2007.05.002
   Bray GA, 2004, AM J CLIN NUTR, V79, P537
   Chang YH, 2008, DIABETES-METAB RES, V24, P629, DOI 10.1002/dmrr.894
   Chen CC, 2009, METABOLISM, V58, P1812, DOI 10.1016/j.metabol.2009.06.013
   Christou GA, 2012, HORM METAB RES, V44, P6, DOI 10.1055/s-0031-1295491
   Cirillo P, 2009, NEPHROL DIAL TRANSPL, V24, P1384, DOI 10.1093/ndt/gfp038
   Simao ANC, 2008, NUTRITION, V24, P675, DOI 10.1016/j.nut.2008.03.021
   Dekker MJ, 2010, AM J PHYSIOL-ENDOC M, V299, pE685, DOI 10.1152/ajpendo.00283.2010
   Devers MC, 2008, DIABETIC MED, V25, P523, DOI 10.1111/j.1464-5491.2008.02408.x
   EMMERSON BT, 1974, ANN RHEUM DIS, V33, P276, DOI 10.1136/ard.33.3.276
   Genuth S, 2003, DIABETES CARE, V26, P3160
   Glantzounis GK, 2005, CURR PHARM DESIGN, V11, P4145, DOI 10.2174/138161205774913255
   Goessling W, 2008, GASTROENTEROLOGY, V135, P1935, DOI 10.1053/j.gastro.2008.09.018
   Graham TE, 2006, NEW ENGL J MED, V354, P2552, DOI 10.1056/NEJMoa054862
   Havel PJ, 1999, DIABETES, V48, P334, DOI 10.2337/diabetes.48.2.334
   Havel PJ, 2005, NUTR REV, V63, P133, DOI [10.1301/nr.2005.may.133-157, 10.1111/j.1753-4887.2005.tb00132.x]
   Iwasaki T, 2008, DIABETES RES CLIN PR, V79, pE13, DOI 10.1016/j.diabres.2007.06.014
   Johnson RJ, 2007, AM J CLIN NUTR, V86, P899
   Kloeting N, 2007, CELL METAB, V6, P79, DOI 10.1016/j.cmet.2007.06.002
   Lee DH, 2009, J EPIDEMIOL COMMUN H, V63, P884, DOI 10.1136/jech.2008.083592
   Lim JS, 2010, NAT REV GASTRO HEPAT, V7, P251, DOI 10.1038/nrgastro.2010.41
   Lippi G, 2007, CLIN CHIM ACTA, V384, P163, DOI 10.1016/j.cca.2007.06.005
   Lippi Giuseppe, 2010, Clin Cardiol, V33, pE76, DOI 10.1002/clc.20511
   MARTIN PJ, 1975, BRIT MED J, V1, P17, DOI 10.1136/bmj.1.5948.17
   Mayes Peter A., 1993, American Journal of Clinical Nutrition, V58, p754S, DOI 10.1093/ajcn/58.5.754S
   MIFFLIN MD, 1990, AM J CLIN NUTR, V51, P241, DOI 10.1093/ajcn/51.2.241
   Perez-Pozo SE, 2010, INT J OBESITY, V34, P454, DOI 10.1038/ijo.2009.259
   REISER S, 1989, AM J CLIN NUTR, V49, P832, DOI 10.1093/ajcn/49.5.832
   Rutledge AC, 2007, NUTR REV, V65, pS13, DOI 10.1301/nr.2007.jun.S13-S23
   Sock ETN, 2010, BRIT J NUTR, V103, P939, DOI 10.1017/S0007114509992819
   Stanhope KL, 2008, CURR OPIN LIPIDOL, V19, P16, DOI 10.1097/MOL.0b013e3282f2b24a
   Stanhope KL, 2011, AM J CLIN NUTR, V94, P112, DOI 10.3945/ajcn.110.002246
   Stanhope KL, 2009, J CLIN INVEST, V119, P1322, DOI 10.1172/JCI37385
   Teff KL, 2004, J CLIN ENDOCR METAB, V89, P2963, DOI 10.1210/jc.2003-031855
   TESCHKE R, 1983, GUT, V24, P625, DOI 10.1136/gut.24.7.625
   Thamer C, 2005, HORM METAB RES, V37, P246, DOI 10.1055/s-2005-861411
   Tschoner A, 2008, OBESITY, V16, P2439, DOI 10.1038/oby.2008.391
   Verrijken A, 2010, INT J OBESITY, V34, P899, DOI 10.1038/ijo.2010.4
   Vukovic J, 2009, ATHEROSCLEROSIS, V207, P255, DOI 10.1016/j.atherosclerosis.2009.04.012
   Wells H.F., 2008, Economic Information Bulletin, V33, P1
   Wolf G, 2007, NUTR REV, V65, P251, DOI [10.1301/nr.2007.may.251-256, 10.1111/j.1753-4887.2007.tb00302.x]
   Yamada J, 2006, ATHEROSCLEROSIS, V189, P198, DOI 10.1016/j.atherosclerosis.2005.11.036
   Yang Q, 2005, NATURE, V436, P356, DOI 10.1038/nature03711
   Yu MA, 2010, J HYPERTENS, V28, P1234, DOI 10.1097/HJH.0b013e328337da1d
NR 46
TC 117
Z9 131
U1 1
U2 21
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD JUL 24
PY 2012
VL 9
AR 68
DI 10.1186/1743-7075-9-68
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 015TN
UT WOS:000309469200001
PM 22828276
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Elmorsy, EA
   Elashry, HA
   Alkhamiss, AS
   Alsaykhan, H
   Hamad, RS
   Abdel-Reheim, MA
   Alsoghair, M
   Alharbi, MS
   Gabr, AM
   Ellethy, AT
   Khodeir, MM
   Hassan, AM
   Elsisi, HA
   Farrag, AA
   Alsoqih, NS
   Sameh, A
   Saber, S
AF Elmorsy, Elsayed A.
   Elashry, Hala A.
   Alkhamiss, Abdullah S.
   Alsaykhan, Hamad
   Hamad, Rabab S.
   Abdel-Reheim, Mustafa Ahmed
   Alsoghair, Mansour
   Alharbi, Mariam S.
   Gabr, Attia M.
   Ellethy, Abousree T.
   Khodeir, Mostafa M.
   Hassan, Ageeb M.
   Elsisi, Hossam A.
   Farrag, Alshaimaa A.
   Alsoqih, Norah Suliman
   Sameh, Ahmed
   Saber, Sameh
TI E1231/NMN protects against experimental metabolic syndrome: the central
   role of SIRT1 in modulating AKT/Nrf2/NFκB signaling
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE E1231; EX527; SIRT1; metabolic syndrome; AKT/Nrf2/NF kappa B; insulin
   resistance
ID NF-KAPPA-B; INSULIN-RESISTANCE; INFLAMMATION; OXYGENASE; MODELS; PLASMA;
   LIVER; MICE
AB Metabolic syndrome (MetS) is a cluster of several disorders where many challenges hinder effective treatment. The downregulation of SIRT1 or inhibition of its activity is implicated in its pathophysiology. We hypothesized that the combined SIRT1 direct activator E1231 and the SIRT1 stabilizer nicotinamide mononucleotide (NMN) could offer a novel approach to mitigate the pathophysiological features of MetS. Our results revealed that E1231 alone or combined with NMN increased SIRT1 level and activity. This SIRT1 activation was accompanied by upregulation in the IRS-1 and activation of AKT. In parallel, the Nrf2 level and activity were increased while the NF kappa B activity and subsequent inflammatory cytokines were decreased. Additionally, SIRT1 activation was associated with improved insulin resistance, blood pressure, lipid profile, fasting blood glucose, glucose tolerance, and kidney and liver functions. Moreover, improved liver histology, decreased hepatic fibrosis markers, and increased survival rates were observed. These protective functions were counteracted when EX527, a SIRT1 inhibitor, was dually administered with E1231. Furthermore, correlation analysis revealed that SIRT1 was negatively correlated with NF kappa B, insulin resistance, and oxidative stress, while positive correlations were observed between SIRT1, p-AKT, and Nrf2 activity. Random Forest regression algorithm and partial dependence plots highlighted the significant roles of SIRT1, IRS-1, p-AKT, and NF kappa B in predicting MetS severity. These analyses underscore the strong interconnections between these signals. This reinforces the central role of SIRT1 in coordinating a multifaceted protective response against MetS. To conclude, SIRT1 alleviates MetS by modulating AKT/Nrf2/NF kappa B signaling and their interactions. Further research is necessary to validate these findings.
C1 [Elmorsy, Elsayed A.; Gabr, Attia M.; Elsisi, Hossam A.] Qassim Univ, Coll Pharm, Dept Pharmacol & Toxicol, Buraydah, Saudi Arabia.
   [Elmorsy, Elsayed A.; Elashry, Hala A.] Mansoura Univ, Fac Med, Dept Clin Pharmacol, Mansoura, Egypt.
   [Alkhamiss, Abdullah S.; Khodeir, Mostafa M.; Hassan, Ageeb M.] Qassim Univ, Coll Med, Dept Pathol, Buraydah, Saudi Arabia.
   [Alsaykhan, Hamad] Qassim Univ, Coll Med, Dept Anat & Histol, Buraydah, Saudi Arabia.
   [Hamad, Rabab S.] King Faisal Univ, Coll Sci, Biol Sci Dept, Al Hasa, Saudi Arabia.
   [Abdel-Reheim, Mustafa Ahmed] Shaqra Univ, Coll Pharm, Dept Pharmacol, Shaqra, Saudi Arabia.
   [Alsoghair, Mansour] Qassim Univ, Coll Med, Dept Family & Community Med, Buraydah, Saudi Arabia.
   [Alharbi, Mariam S.] Qassim Univ, Coll Med, Dept Med, Buraydah, Saudi Arabia.
   [Ellethy, Abousree T.] Qassim Univ, Coll Dent, Dept Basic Oral Sci & Dent Educ, Biochem Div, Buraydah, Saudi Arabia.
   [Khodeir, Mostafa M.] Cairo Univ, Fac Med, Dept Pathol, Cairo, Egypt.
   [Elsisi, Hossam A.] Zagazig Univ, Fac Med, Dept Clin Pharmacol, Zagazig, Egypt.
   [Farrag, Alshaimaa A.] Univ Bisha, Coll Med, Dept Anat, Bisha, Saudi Arabia.
   [Alsoqih, Norah Suliman] Qassim Univ, Coll Med, Dept Pediat, Buraydah, Saudi Arabia.
   [Sameh, Ahmed] Egypt Univ Informat, Fac Comp & Informat Sci, Cairo, Egypt.
   [Saber, Sameh] Delta Univ Sci & Technol, Fac Pharm, Dept Pharmacol, Gamasa, Egypt.
C3 Qassim University; Egyptian Knowledge Bank (EKB); Mansoura University;
   Qassim University; Qassim University; King Faisal University; Shaqra
   University; Qassim University; Qassim University; Qassim University;
   Egyptian Knowledge Bank (EKB); Cairo University; Egyptian Knowledge Bank
   (EKB); Zagazig University; University of Bisha; Qassim University; Delta
   University for Science & Technology
RP Elmorsy, EA (corresponding author), Qassim Univ, Coll Pharm, Dept Pharmacol & Toxicol, Buraydah, Saudi Arabia.; Elmorsy, EA (corresponding author), Mansoura Univ, Fac Med, Dept Clin Pharmacol, Mansoura, Egypt.; Hamad, RS (corresponding author), King Faisal Univ, Coll Sci, Biol Sci Dept, Al Hasa, Saudi Arabia.; Abdel-Reheim, MA (corresponding author), Shaqra Univ, Coll Pharm, Dept Pharmacol, Shaqra, Saudi Arabia.; Farrag, AA (corresponding author), Univ Bisha, Coll Med, Dept Anat, Bisha, Saudi Arabia.; Saber, S (corresponding author), Delta Univ Sci & Technol, Fac Pharm, Dept Pharmacol, Gamasa, Egypt.
EM a.almarsa@qu.edu.sa; m.ahmed@su.edu.sa; sameh.saber@deltauniv.edu.eg;
   rhamad@kfu.edu.sa; afarraj@ub.edu.sa
RI Sameh, A./ADT-8344-2022; Hamad, Rabab/H-9104-2016; saber,
   Sameh/AAE-8616-2020; Khodeir, Mostafa/JEO-9343-2023; ALKHAMISS,
   ABDULLAH/LUA-0493-2024; Elmorsy, Elsayed/KXR-1785-2024
OI Elmorsy, Elsayed A./0000-0001-6165-3847; Farrag, Alshaimaa A.
   M./0009-0007-0696-853X
FU International Collaboration Office at Delta University; Deanship of
   Scientific Research, Vice Presidency for Graduate Studies and Scientific
   Research, King Faisal University, Saudi Arabia [KFU250814]; Deanship of
   Graduate Studies and Scientific Research at Qassim University
   [QU-APC-2025]; Deanship of Graduate Studies and Scientific Research at
   University of Bisha; Deanship of Scientific Research at Shaqra
   University
FX The authors would like to express their gratitude to the International
   Collaboration Office at Delta University for Science and Technology for
   their valuable support and assistance. The Researchers would like to
   thank the Deanship of Graduate Studies and Scientific Research at Qassim
   University for financial support (QU-APC-2025). The authors are thankful
   to the Deanship of Graduate Studies and Scientific Research at
   University of Bisha for supporting this work through the Fast-Track
   Research Support Program. The authors would like to thank the Deanship
   of Scientific Research at Shaqra University for supporting this work.
CR Abdelhamid AM, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.887233
   Aguilar-Salinas Carlos A, 2019, F1000Res, V8, DOI 10.12688/f1000research.17122.1
   Alemany M, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25042251
   Báez AM, 2024, CURR ISSUES MOL BIOL, V46, P634, DOI 10.3390/cimb46010041
   Cantó C, 2012, PHARMACOL REV, V64, P166, DOI 10.1124/pr.110.003905
   Cavalu S, 2022, FASEB J, V36, DOI 10.1096/fj.202200749R
   Chooi YC, 2019, METABOLISM, V92, P6, DOI 10.1016/j.metabol.2018.09.005
   Dali-Youcef N, 2013, ANN MED, V45, P242, DOI 10.3109/07853890.2012.705015
   de Abreu VG, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0180947
   Ding YW, 2016, INT J MOL MED, V37, P1049, DOI 10.3892/ijmm.2016.2503
   Dundar C, 2023, BMC PEDIATR, V23, DOI 10.1186/s12887-023-03892-8
   Elbaset MA, 2024, J CELL MOL MED, V28, DOI 10.1111/jcmm.18116
   Feng TT, 2018, ATHEROSCLEROSIS, V274, P172, DOI 10.1016/j.atherosclerosis.2018.04.039
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Gomes AP, 2013, CELL, V155, P1624, DOI 10.1016/j.cell.2013.11.037
   Guéant JL, 2014, PFLUG ARCH EUR J PHY, V466, P833, DOI 10.1007/s00424-013-1339-4
   Guo R, 2014, DIABETES VASC DIS RE, V11, P92, DOI 10.1177/1479164113520332
   Hah YS, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0087733
   Han JX, 2023, CURR ISSUES MOL BIOL, V45, P5052, DOI 10.3390/cimb45060321
   Huang DW, 2020, FOOD SCI NUTR, V8, P5710, DOI 10.1002/fsn3.1868
   Huang HY, 2023, FOOD CHEM TOXICOL, V178, DOI 10.1016/j.fct.2023.113878
   Jha BK, 2023, DIABETOLOGY, V4, P134, DOI 10.3390/diabetology4020015
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   Keshk WA, 2020, ARCH BIOCHEM BIOPHYS, V680, DOI 10.1016/j.abb.2019.108227
   Kosgei VJ, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9081882
   Kracht M, 2020, J ALLERGY CLIN IMMUN, V146, P694, DOI 10.1016/j.jaci.2020.07.027
   Li XL, 2013, ACTA BIOCH BIOPH SIN, V45, P51, DOI 10.1093/abbs/gms108
   Lillich FF, 2021, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.554961
   Liu ZX, 2016, MOL MED REP, V14, P1323, DOI 10.3892/mmr.2016.5393
   Lomba A, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-60
   Ma XR, 2020, FRONT NEUROSCI-SWITZ, V13, DOI 10.3389/fnins.2019.01400
   MAINES MD, 1988, FASEB J, V2, P2557, DOI 10.1096/fasebj.2.10.3290025
   Maines MD, 1999, J PHARMACOL EXP THER, V291, P911
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mohamed S.M., 2023, Food Chem Adv, V3, DOI 10.1016/j.focha.2023.100335
   Nasr M, 2022, BIOMED PHARMACOTHER, V153, DOI 10.1016/j.biopha.2022.113409
   Pillai VB, 2014, CIRC RES, V114, P368, DOI 10.1161/CIRCRESAHA.113.300536
   Powers SK, 2024, FREE RADICAL BIO MED, V224, P470, DOI 10.1016/j.freeradbiomed.2024.07.041
   Reddy GK, 1996, CLIN BIOCHEM, V29, P225, DOI 10.1016/0009-9120(96)00003-6
   Reed S., 2024, J. Pharmacol. Exp. Ther., V389, P129, DOI [10.1124/jpet.129.986990, DOI 10.1124/JPET.129.986990]
   Ren ZH, 2019, CELL MOL BIOL LETT, V24, DOI 10.1186/s11658-019-0158-9
   Salminen A, 2011, J MOL MED, V89, P667, DOI 10.1007/s00109-011-0748-0
   Savova MS, 2023, BIOMED PHARMACOTHER, V159, DOI 10.1016/j.biopha.2023.114244
   Smith MR, 2014, HUM MOL GENET, V23, P2995, DOI 10.1093/hmg/ddu010
   Tanno M, 2007, J BIOL CHEM, V282, P6823, DOI 10.1074/jbc.M609554200
   Wang Y, 2012, PHARMACOL THERAPEUT, V136, P305, DOI 10.1016/j.pharmthera.2012.08.009
   Wang YJ, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.755060
   Yeung D., 2015, Does a high-fat diet cause inflammation in female rat brain?
   Yi L, 2023, GEROSCIENCE, V45, P29, DOI 10.1007/s11357-022-00705-1
   Youssef ME, 2022, ENVIRON SCI POLLUT R, V29, P25723, DOI 10.1007/s11356-021-17831-6
   Yuan XP, 2024, EUR ARCH PSY CLIN N, V274, P1063, DOI 10.1007/s00406-023-01618-6
NR 51
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD MAR 17
PY 2025
VL 16
AR 1558709
DI 10.3389/fphar.2025.1558709
PG 18
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 0SP0N
UT WOS:001455025500001
PM 40166461
OA gold
DA 2025-06-11
ER

PT J
AU Aljehani, AA
   Albadr, NA
   Nasrullah, MZ
   Neamatallah, T
   Eid, BG
   Abdel-Naim, AB
AF Aljehani, Abeer A.
   Albadr, Nawal A.
   Nasrullah, Mohammed Z.
   Neamatallah, Thikryat
   Eid, Basma G.
   Abdel-Naim, Ashraf B.
TI Icariin ameliorates metabolic syndrome-induced benign prostatic
   hyperplasia in rats
SO ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
LA English
DT Article
DE Icariin; Benign prostatic hyperplasia; Metabolic syndrome; Adenosine
   monophosphate (AMP)-activated protein kinase; High fructose-drinking
   water; High-salt diet
ID OXIDATIVE STRESS; CANCER CELLS; EXPRESSION; GROWTH; APOPTOSIS;
   ACTIVATION; PATHWAY
AB Metabolic syndrome (MetS) is an immense health issue that causes serious complications in aging males including BPH. Icariin (ICA) is a flavonol glycoside that exerts a plethora of pharmacological effects. The present investigation tested the potential of ICA to ameliorate benign prostatic hyperplasia (BPH) induced by MetS in rats. Animals were allocated to 5 groups in which the first and second groups were kept on water and regular food pellets. MetS was induced in the third, fourth, and fifth groups by keeping the animals on high fructose and salt diets for twelve consecutive weeks. These groups were given vehicle, ICA (25 mg/kg), and ICA (50 mg/kg), respectively. MetS was confirmed by an increase in rats' weight, accumulation of visceral fat, insulin resistance, and dyslipidemia. This was accompanied by manifestation of BPH including increased prostate weight, prostate index, and histopathological alterations. Treating the animals with both doses of ICA significantly ameliorated the increase in weight and index of the prostate as well as altered prostate histopathology. In addition, ICA significantly decreased cyclin D1 expression, upregulated Bax, and downregulated Bcl2 mRNA expression. ICA prevented lipid peroxidation, reduced glutathione depletion, and catalase exhaustion, which further lowered markers of prostate inflammation such as interleukin-6 and tumor necrosis factor-alpha. Moreover, ICA prevented the decrease in prostate content of phosphorylated 5 '-adenosine monophosphate (AMP)-activated protein kinase (pAMPK). In conclusion, ICA protects against MetS-induced BPH. This is due to its antiproliferative, proapoptotic, antioxidant, and anti-inflammatory activities as well as the activation of AMPK.
C1 [Aljehani, Abeer A.; Albadr, Nawal A.] King Saud Univ, Coll Food & Agr Sci, Dept Food Sci & Nutr, Riyadh, Saudi Arabia.
   [Nasrullah, Mohammed Z.; Neamatallah, Thikryat; Eid, Basma G.; Abdel-Naim, Ashraf B.] King Abdulaziz Univ, Fac Pharm, Dept Pharmacol & Toxicol, Jeddah, Saudi Arabia.
C3 King Saud University; King Abdulaziz University
RP Abdel-Naim, AB (corresponding author), King Abdulaziz Univ, Fac Pharm, Dept Pharmacol & Toxicol, Jeddah, Saudi Arabia.
EM aaabdulakahman1@kau.edu.sa
RI Aljehani, Abeer/NIS-8927-2025; Eid, Basma/F-3962-2018; Nasrullah,
   Mohammed/AAS-5040-2021; Neamatallah, Thikryat/L-7201-2016; Abdel-Naim,
   Ashraf/J-3199-2012
OI Nasrullah, Mohammed/0000-0002-4755-0742
FU Deanship of Scientific Research in King Saud University through the
   initiative of DSR Graduate Students Research Support (GSR)
FX The study was funded by the Deanship of Scientific Research in King Saud
   University through the initiative of DSR Graduate Students Research
   Support (GSR).
CR Aaron-Brooks LM, 2019, PROSTATE, V79, P980, DOI 10.1002/pros.23809
   Abdallah HM, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1340-5
   Alhakamy NA, 2020, PHARMACEUTICS, V12, DOI 10.3390/pharmaceutics12040346
   Aljehani AA, 2020, SAUDI PHARM J, V28, P1309, DOI 10.1016/j.jsps.2020.08.021
   Azhar AS, 2020, EUR J PHARMACOL, V882, DOI 10.1016/j.ejphar.2020.173278
   de Ferranti S, 2008, CLIN CHEM, V54, P945, DOI 10.1373/clinchem.2007.100156
   Devlin CM, 2021, BJU INT, V127, P389, DOI 10.1111/bju.15229
   Ding J, 2018, ANDROLOGIA, V50, DOI 10.1111/and.12802
   ELLMAN GL, 1959, ARCH BIOCHEM BIOPHYS, V82, P70, DOI 10.1016/0003-9861(59)90090-6
   Green CJ, 2011, BIOCHEM J, V435, P463, DOI 10.1042/BJ20101517
   Gu ZF, 2017, ENVIRON TOXICOL PHAR, V54, P7, DOI 10.1016/j.etap.2017.06.004
   Han N, 2023, BIOFACTORS, V49, DOI 10.1002/biof.1591
   He CY, 2020, ADV PHARMACOL, V87, P179, DOI 10.1016/bs.apha.2019.10.004
   HE W, 1995, ARZNEIMITTELFORSCH, V45-2, P910
   Huang SJ, 2019, J BUON, V24, P990
   Huang X, 2007, EUR J PHARMACOL, V564, P26, DOI 10.1016/j.ejphar.2007.02.039
   Jeon SM, 2016, EXP MOL MED, V48, DOI 10.1038/emm.2016.81
   Kim B, 2020, INT J ONCOL, V56, P821, DOI 10.3892/ijo.2020.4970
   Kopp W, 2018, NUTR METAB INSIGHTS, V11, DOI 10.1177/1178638818773072
   Li CR, 2015, LIFE SCI, V126, P57, DOI 10.1016/j.lfs.2015.01.006
   Li CY, 2021, CANCER CELL INT, V21, DOI 10.1186/s12935-021-01910-2
   Lim R, 2015, PLACENTA, V36, P454, DOI 10.1016/j.placenta.2015.01.007
   Lin CC, 2004, CLIN EXP PHARMACOL P, V31, P65, DOI 10.1111/j.1440-1681.2004.03951.x
   Liu J, 2018, J ORAL PATHOL MED, V47, P198, DOI 10.1111/jop.12659
   Lu YF, 2014, MOLECULES, V19, P18179, DOI 10.3390/molecules191118179
   Madersbacher S, 2019, GERONTOLOGY, V65, P458, DOI 10.1159/000496289
   Mahjoub S, 2012, CASP J INTERN MED, V3, P386
   Makarova MN, 2007, J ETHNOPHARMACOL, V114, P412, DOI 10.1016/j.jep.2007.08.021
   MCCLINTON S, 1990, BRIT J CANCER, V61, P400, DOI 10.1038/bjc.1990.87
   Mosli HH, 2015, SCI REP-UK, V5, DOI 10.1038/srep15639
   Ngai HY, 2017, ASIAN J UROL, V4, P164, DOI 10.1016/j.ajur.2017.05.001
   NISHIKIMI M, 1972, BIOCHEM BIOPH RES CO, V46, P849, DOI 10.1016/S0006-291X(72)80218-3
   Ozden C, 2007, EUR UROL, V51, P199, DOI 10.1016/j.eururo.2006.05.040
   Reddy P, 2019, CLIN CHIM ACTA, V496, P35, DOI 10.1016/j.cca.2019.06.019
   Ribeiro DL, 2006, EUR J HISTOCHEM, V50, P51
   Ricke WA, 2011, DIFFERENTIATION, V82, P165, DOI 10.1016/j.diff.2011.08.005
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Song LJ, 2020, CANCER SCI, V111, P4242, DOI 10.1111/cas.14648
   Stroup SP, 2012, BJU INT, V109, P84, DOI 10.1111/j.1464-410X.2011.10250.x
   THEYER G, 1992, LAB INVEST, V66, P96
   Tian ML, 2018, BRAZ J MED BIOL RES, V51, DOI [10.1590/1414-431x20187151, 10.1590/1414-431X20187151]
   UCHIYAMA M, 1978, ANAL BIOCHEM, V86, P271, DOI 10.1016/0003-2697(78)90342-1
   Udensi UK, 2016, J EXP CLIN CANC RES, V35, DOI 10.1186/s13046-016-0418-8
   Vanella L, 2014, UROLOGY, V83, DOI 10.1016/j.urology.2014.03.007
   Vignozzi L, 2016, NAT REV UROL, V13, P108, DOI 10.1038/nrurol.2015.301
   Wang PZ, 2020, BIOSCIENCE REP, V40, DOI 10.1042/BSR20203107
   Wang Q, 2011, INT J ONCOL, V39, P973, DOI 10.3892/ijo.2011.1086
   Wang ZM, 2015, MOL MED REP, V12, P6815, DOI 10.3892/mmr.2015.4282
   Wu JF, 2011, IMMUNOPHARM IMMUNOT, V33, P49, DOI 10.3109/08923971003725144
   Wu SQ, 2019, J INT MED RES, V47, P5389, DOI 10.1177/0300060519876823
   Xiong Y, 2021, TRANSL ANDROL UROL, V10, DOI 10.21037/tau-20-1127
   Xu HB, 2007, VASC PHARMACOL, V47, P18, DOI 10.1016/j.vph.2007.03.002
   Xu HB, 2007, J CARDIOVASC PHARM, V49, P207, DOI 10.1097/FJC.0b013e3180325abe
   Yin Z, 2015, ASIAN J ANDROL, V17, P826, DOI 10.4103/1008-682X.148081
   Yoon JW, 2021, ANIM BIOSCI, V34, P546, DOI 10.5713/ajas.20.0046
   Zhang JJ, 2021, PROSTATE CANCER P D, V24, P49, DOI 10.1038/s41391-020-00277-1
   Zhang M, 2018, MOL CELL BIOCHEM, V437, P45, DOI 10.1007/s11010-017-3094-x
   Zou C, 2016, WORLD J UROL, V34, P281, DOI 10.1007/s00345-015-1626-0
NR 58
TC 12
Z9 13
U1 0
U2 38
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0944-1344
EI 1614-7499
J9 ENVIRON SCI POLLUT R
JI Environ. Sci. Pollut. Res.
PD MAR
PY 2022
VL 29
IS 14
BP 20370
EP 20378
DI 10.1007/s11356-021-17245-4
EA NOV 2021
PG 9
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA ZN4QS
UT WOS:000714334100001
PM 34734339
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Hermans, MP
   Lempereur, P
   Salembier, JP
   Maes, N
   Albert, A
   Jansen, O
   Pincemail, J
AF Hermans, Michel P.
   Lempereur, Philippe
   Salembier, Jean-Paul
   Maes, Nathalie
   Albert, Adelin
   Jansen, Olivia
   Pincemail, Joel
TI Supplementation Effect of a Combination of Olive (Olea europea
   L.) Leaf and Fruit Extracts in the Clinical Management of Hypertension
   and Metabolic Syndrome
SO ANTIOXIDANTS
LA English
DT Article
DE Olea europea L; olive extracts; oleuropein; hydroxytyrosol;
   hypertension; metabolic syndrome
ID BLOOD-PRESSURE; OXIDATIVE STRESS; ENDOTHELIAL FUNCTION; MEDITERRANEAN
   DIET; OIL CONSUMPTION; HYDROXYTYROSOL; RISK; INFLAMMATION; POLYPHENOLS;
   OLEUROPEIN
AB Background: The role of herbal products in the prevention of cardiovascular disease requires supporting evidence. This open pilot study assessed the effect of 2-month supplementation of a combination of olive leaf and fruit extracts (Tensiofytol(R), Tilman SA, Baillonville, Belgium) in the clinical management of hypertension and metabolic syndrome (MetS). Methods: A total of 663 (pre)-hypertensive patients were enrolled by general practitioners and supplemented for two months with Tensiofytol(R), two capsules per day (100 mg/d of oleuropein and 20 mg/d of hydroxytyrosol). Systolic and diastolic blood pressures (SBP/DBP) were measured before and after treatment. Markers of MetS, high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), fasting blood glucose (FG) and waist circumference (WC), were also examined. Results: Significant reductions (p < 0.0001) in SBP/DBP (13 +/- 10/7.1 +/- 6.6 mmHg) were observed and similarly in pre-diabetic and diabetic patients. Improvements in SBP/DPB were independent of age and gender but greater for elevated baseline SBP/DBP. Tensiofytol(R) supplementation also significantly improved markers of MetS, with a decrease of TG (11%), WC (1.4%) and FG (4.8%) and an increase of HDL-C (5.3%). Minor side effects were reported in 3.2% patients. Conclusions: This real-life, observational, non-controlled, non-randomized pilot study shows that supplementation of a combination of olive leaf and fruit extracts may be used efficiently and safely in reducing hypertension and MetS markers.
C1 [Hermans, Michel P.] UCLouvain, Inst Rech Expt & Clin, Serv Endocrinol & Nutr & Pole Endocrinol Diabete, B-1200 Brussels, Belgium.
   [Lempereur, Philippe] Ctr Hosp Bois Abbaye, Serv Cardiol, B-4100 Seraing, Belgium.
   [Salembier, Jean-Paul] CHU UCL Namur, Serv Cardiol, Site Sainte Elisabeth, B-5000 Namur, Belgium.
   [Maes, Nathalie; Albert, Adelin] Univ Hosp Liege, Biostat & Medicoecon Informat Dept, B-4000 Liege, Belgium.
   [Jansen, Olivia] Univ Liege, Ctr Interdisciplinaire Rech Medicament CIRM, Lab Pharmacognosie, B-4000 Liege, Belgium.
   [Pincemail, Joel] CHU, CREDEC, Dept Cardiovasc Surg, B-4000 Liege, Belgium.
   [Pincemail, Joel] CHU, Platform Nutr Antioxydante & Sante, B-4000 Liege, Belgium.
   [Pincemail, Joel] Univ Liege, B-4000 Liege, Belgium.
C3 Universite Catholique Louvain; University of Liege; University of Liege;
   University of Liege; University of Liege; University of Liege
RP Pincemail, J (corresponding author), CHU, CREDEC, Dept Cardiovasc Surg, B-4000 Liege, Belgium.; Pincemail, J (corresponding author), CHU, Platform Nutr Antioxydante & Sante, B-4000 Liege, Belgium.; Pincemail, J (corresponding author), Univ Liege, B-4000 Liege, Belgium.
EM michel.hermans@uclouvain.be; philippe.lempereur@skynet.be;
   jeanpaulsalembier@yahoo.fr; nmaes@chuliege.be; aalbert@uliege.be;
   ojansen@uliege.be; j.pincemail@chuliege.be
CR Ali KM, 2012, BRIT J PHARMACOL, V167, P1177, DOI 10.1111/j.1476-5381.2012.02081.x
   Alonso A, 2004, LIPIDS, V39, P1233, DOI 10.1007/s11745-004-1352-x
   Martín MA, 2010, MOL NUTR FOOD RES, V54, P956, DOI 10.1002/mnfr.200900159
   Ansseau M., 2012, ACTA PSYCHIAT BELG, V112, P5
   Appelboom Thierry, 2014, Open Rheumatol J, V8, P77, DOI 10.2174/1874312901408010077
   Barrows IR, 2019, ADV CHRONIC KIDNEY D, V26, P122, DOI 10.1053/j.ackd.2019.03.001
   Berrougui H, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/208062
   Birringer M, 2011, PHARM RES-DORDR, V28, P2680, DOI 10.1007/s11095-011-0551-1
   Bondia-Pons I, 2007, J NUTR, V137, P84, DOI 10.1093/jn/137.1.84
   Bulotta S, 2014, J TRANSL MED, V12, DOI 10.1186/s12967-014-0219-9
   Cabrera-Vique C, 2015, NUTR HOSP, V32, P242, DOI 10.3305/nh.2015.32.1.8644
   Castañer O, 2011, CLIN NUTR, V30, P490, DOI 10.1016/j.clnu.2011.01.013
   Chartoumpekis DV, 2013, CURR DIABETES REV, V9, P137, DOI 10.2174/1573399811309020005
   Cherif S, 1996, J Pharm Belg, V51, P69
   Colica C, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/2473495
   Covas MI, 2006, ANN INTERN MED, V145, P333, DOI 10.7326/0003-4819-145-5-200609050-00006
   Davis CR, 2017, AM J CLIN NUTR, V105, P1305, DOI 10.3945/ajcn.116.146803
   de Bock M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057622
   Di Ciaula A, 2018, ANN GASTROENTEROL, V31, P685, DOI 10.20524/aog.2018.0304
   Fernández-Garcia JC, 2013, CURR VASC PHARMACOL, V11, P906, DOI 10.2174/15701611113116660175
   Fuccelli R, 2018, MOLECULES, V23, DOI 10.3390/molecules23123212
   García-Fernández E, 2014, NUTRIENTS, V6, P3474, DOI 10.3390/nu6093474
   García-Villalba R, 2014, EUR J NUTR, V53, P1015, DOI 10.1007/s00394-013-0604-9
   García-Villalba R, 2010, ANAL BIOANAL CHEM, V398, P463, DOI 10.1007/s00216-010-3899-x
   George ES, 2019, CRIT REV FOOD SCI, V59, P2772, DOI 10.1080/10408398.2018.1470491
   Ghobadi S, 2019, CRIT REV FOOD SCI, V59, P2110, DOI 10.1080/10408398.2018.1438349
   Granados-Principal S, 2010, NUTR REV, V68, P191, DOI 10.1111/j.1753-4887.2010.00278.x
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Guasch-Ferré M, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/6723931
   Guasch-Ferré M, 2015, AM J CLIN NUTR, V102, P479, DOI 10.3945/ajcn.115.112029
   Guasch-Ferré M, 2014, BMC MED, V12, DOI 10.1186/1741-7015-12-78
   Hernáez A, 2017, CIRCULATION, V135, P633, DOI 10.1161/CIRCULATIONAHA.116.023712
   Hoffman R, 2015, NUTRIENTS, V7, P7925, DOI 10.3390/nu7095371
   Jones DP, 2006, ANTIOXID REDOX SIGN, V8, P1865, DOI 10.1089/ars.2006.8.1865
   Khymenets O, 2010, DRUG METAB DISPOS, V38, P1417, DOI 10.1124/dmd.110.032821
   Lewington S, 2002, LANCET, V360, P1903, DOI 10.1016/S0140-6736(02)11911-8
   Lockyer S, 2017, EUR J NUTR, V56, P1421, DOI 10.1007/s00394-016-1188-y
   Markovic AK, 2019, MOLECULES, V24, DOI 10.3390/molecules24102001
   Martinez-Gonzalez M.A., 2015, in cardiovascular diseases, V58, P60, DOI [10.1016/j.pcad.2015.04.003, DOI 10.1016/J.PCAD.2015.04.003]
   Martínez-Huélamo M, 2017, ANTIOXIDANTS-BASEL, V6, DOI 10.3390/antiox6040073
   Medina-Remón A, 2015, NUTR METAB CARDIOVAS, V25, P60, DOI 10.1016/j.numecd.2014.09.001
   Miro-Casas E, 2003, CLIN CHEM, V49, P945, DOI 10.1373/49.6.945
   Moerland M, 2012, INT J VASC MED, V2012, DOI 10.1155/2012/904141
   Monserrat-Mesquida M, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9030236
   Moreno-Luna R, 2012, AM J HYPERTENS, V25, P1299, DOI 10.1038/ajh.2012.128
   Muhindo CT, 2017, COMPLEMENT THER MED, V35, P140, DOI 10.1016/j.ctim.2017.10.014
   Omar Syed Haris, 2010, Sci Pharm, V78, P133, DOI 10.3797/scipharm.0912-18
   Pastor A, 2016, J CHROMATOGR A, V1437, P183, DOI 10.1016/j.chroma.2016.02.016
   Perona JS, 2004, CLIN NUTR, V23, P1113, DOI 10.1016/j.clnu.2004.02.004
   Perrinjaquet-Moccetti T, 2008, PHYTOTHER RES, V22, P1239, DOI 10.1002/ptr.2455
   Pourová J, 2018, VASC PHARMACOL, V111, P36, DOI 10.1016/j.vph.2018.08.008
   Richard N, 2011, PLANTA MED, V77, P1890, DOI 10.1055/s-0031-1280022
   Robles-Almazan M, 2018, FOOD RES INT, V105, P654, DOI 10.1016/j.foodres.2017.11.053
   Romero M, 2016, FOOD FUNCT, V7, P584, DOI [10.1039/C5FO01101A, 10.1039/c5fo01101a]
   Schmitt Christoph A, 2007, Atherosclerosis, V195, pe58, DOI 10.1016/j.atherosclerosis.2007.02.024
   Schwingshackl L, 2017, NUTR DIABETES, V7, DOI 10.1038/nutd.2017.12
   Schwingshackl L, 2015, NUTRIENTS, V7, P7651, DOI 10.3390/nu7095356
   Serreli G, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9020478
   Steven S, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/7092151
   Susalit E, 2011, PHYTOMEDICINE, V18, P251, DOI 10.1016/j.phymed.2010.08.016
   Toledo E, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-207
   Tonelli C, 2018, ANTIOXID REDOX SIGN, V29, P1727, DOI 10.1089/ars.2017.7342
   Touyz RM, 2020, CAN J CARDIOL, V36, P659, DOI 10.1016/j.cjca.2020.02.081
   Tran V, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00148
   Tuttolomondo A, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20194716
   Tziomalos K, 2010, NUTR METAB CARDIOVAS, V20, P140, DOI 10.1016/j.numecd.2009.08.006
   Valls RM, 2015, FOOD CHEM, V167, P30, DOI 10.1016/j.foodchem.2014.06.107
   Verhoeven V, 2015, BMC COMPLEM ALTERN M, V15, DOI 10.1186/s12906-015-0576-9
   Vona R, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8267234
   Wainstein J, 2012, J MED FOOD, V15, P605, DOI 10.1089/jmf.2011.0243
   Wang WR, 2019, PHYTOMEDICINE, V52, P206, DOI 10.1016/j.phymed.2018.09.208
   Widmer RJ, 2013, EUR J NUTR, V52, P1223, DOI 10.1007/s00394-012-0433-2
   Williams B, 2018, J HYPERTENS, V36, P1953, DOI 10.1097/HJH.0000000000001940
   Zhou YP, 2019, CHEM BIODIVERS, V16, DOI 10.1002/cbdv.201900400
   Zuo L, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20184472
NR 75
TC 26
Z9 26
U1 1
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD SEP
PY 2020
VL 9
IS 9
AR 872
DI 10.3390/antiox9090872
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA OG6ZK
UT WOS:000582029500001
PM 32942738
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhang, LH
   Zhu, XY
   Eirin, A
   Nargesi, AA
   Woollard, JR
   Santelli, A
   Sun, IO
   Textor, SC
   Lerman, LO
AF Zhang, Li-Hong
   Zhu, Xiang-Yang
   Eirin, Alfonso
   Nargesi, Arash Aghajani
   Woollard, John R.
   Santelli, Adrian
   Sun, In O.
   Textor, Stephen C.
   Lerman, Lilach O.
TI Early podocyte injury and elevated levels of urinary podocyte-derived
   extracellular vesicles in swine with metabolic syndrome: role of
   podocyte mitochondria
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE extracellular vesicles; metabolic syndrome; mitochondria; podocyte
ID KIDNEY-DISEASE; DIABETES-MELLITUS; OXIDATIVE STRESS; OBESITY;
   PROTECTION; NEPHRIN; MICROVESICLES; BIOENERGETICS; EXPRESSION; PEPTIDE
AB Metabolic syndrome (MetS) is associated with nutrient surplus and kidney hyperfiltration, accelerating chronic renal failure. The potential involvement of podocyte damage in early MetS remains unclear. Mitochondrial dysfunction is an important determinant of renal damage, but whether it contributes to MetS-related podocyte injury remains unknown. Domestic pigs were studied after 16 wk of diet-induced MetS, MetS treated with the mitochondria-targeted peptide elamipretide (ELAM; 0.1 mg.kg(-1).day(-1) sc) for the last month of diet, and lean controls (n = 6 pigs/group). Glomerular filtration rate (GFR) and renal blood flow (RBF) were measured using multidetector computed tomography, and podocyte and mitochondrial injury were measured by light and electron microscopy. Urinary levels of podocyte-derived extracellular vesicles (pEVs; nephrin positive/podocalyxin positive) were characterized by flow cytometry. Body weight, blood pressure, RBF, and GFR were elevated in MetS. Glomerular size and glomerular injury score were also elevated in MetS and decreased after ELAM treatment. Evidence of podocyte injury, impaired podocyte mitochondria, and foot process width were all increased in MetS but restored with ELAM. The urinary concentration of pEVs was elevated in MetS pigs and directly correlated with renal dysfunction, glomerular injury, and fibrosis and inversely correlated with glomerular nephrin expression. Additionally, pEV numbers were elevated in the urine of obese compared with lean human patients. Early MetS induces podocyte injury and mitochondrial damage, which can be blunted by mitoprotection. Urinary pEVs reflecting podocyte injury might represent early markers of MetS-related kidney disease and a novel therapeutic target.
C1 [Zhang, Li-Hong; Zhu, Xiang-Yang; Eirin, Alfonso; Nargesi, Arash Aghajani; Woollard, John R.; Santelli, Adrian; Sun, In O.; Textor, Stephen C.; Lerman, Lilach O.] Mayo Clin, Div Nephrol & Hypertens, 200 First St SW, Rochester, MN 55905 USA.
   [Zhang, Li-Hong] Fudan Univ, Peoples Hosp Shanghai 5, Dept Nephrol, Shanghai, Peoples R China.
C3 Mayo Clinic; Fudan University
RP Lerman, LO (corresponding author), Mayo Clin, Div Nephrol & Hypertens, 200 First St SW, Rochester, MN 55905 USA.
EM Lerman.Lilach@mayo.edu
RI Eirin, Alfonso/N-9873-2013; Lerman, Lilach/M-4962-2017; Nargesi,
   Arash/AAM-5298-2020
OI Eirin, Alfonso/0000-0002-3864-9644
FU Stealth Biotherapeutics; National Institutes of Health [DK-120242,
   DK-100081, DK-106427, DK-104273, HL-123160, DK-102325]
FX This work was supported by a research grant from Stealth Biotherapeutics
   and by National Institutes of Health Grants DK-120242, DK-100081,
   DK-106427, DK-104273, HL-123160, and DK-102325.
CR Abe Y, 2010, AM J PHYSIOL-CELL PH, V299, pC464, DOI 10.1152/ajpcell.00563.2009
   Ayers L, 2015, CLIN SCI, V129, P915, DOI 10.1042/CS20140623
   Birk AV, 2014, BRIT J PHARMACOL, V171, P2017, DOI 10.1111/bph.12468
   Birk AV, 2015, BBA-BIOENERGETICS, V1847, P1075, DOI 10.1016/j.bbabio.2015.06.006
   Birk AV, 2013, J AM SOC NEPHROL, V24, P1250, DOI 10.1681/ASN.2012121216
   Blanco S, 2005, AM J HYPERTENS, V18, P557, DOI 10.1016/j.amjhyper.2004.10.034
   Burger D, 2014, J AM SOC NEPHROL, V25, P1401, DOI 10.1681/ASN.2013070763
   Chen HM, 2006, AM J KIDNEY DIS, V48, P772, DOI 10.1053/j.ajkd.2006.07.025
   Deji N, 2009, AM J PHYSIOL-RENAL, V296, pF118, DOI 10.1152/ajprenal.00110.2008
   Eirin A, 2017, TRANSL RES, V184, P45, DOI 10.1016/j.trsl.2017.03.002
   Eirin A, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.115.003118
   Eirin A, 2014, CARDIOVASC RES, V103, P461, DOI 10.1093/cvr/cvu157
   Eirin A, 2012, HYPERTENSION, V60, P1242, DOI 10.1161/HYPERTENSIONAHA.112.199919
   Ferraro PM, 2011, METAB SYNDR RELAT D, V9, P381, DOI 10.1089/met.2011.0040
   Garovic VD, 2007, NEPHROL DIAL TRANSPL, V22, P1136, DOI 10.1093/ndt/gfl711
   Gilani SI, 2017, J AM SOC NEPHROL, V28, P3363, DOI 10.1681/ASN.2016111202
   Hagiwara M, 2006, KIDNEY INT, V69, P1146, DOI 10.1038/sj.ki.5000207
   Imasawa T, 2013, INT J BIOCHEM CELL B, V45, P2109, DOI 10.1016/j.biocel.2013.06.013
   Jayachandran M, 2015, BIOL SEX DIFFER, V6, DOI 10.1186/s13293-015-0021-2
   Kriz W, 1999, CURR OPIN NEPHROL HY, V8, P489, DOI 10.1097/00041552-199907000-00014
   Kwon SH, 2017, NEPHROL DIAL TRANSPL, V32, P800, DOI 10.1093/ndt/gfw077
   Kwon SH, 2015, RADIOLOGY, V276, P490, DOI 10.1148/radiol.2015141892
   Mallipattu SK, 2015, J CLIN INVEST, V125, P1347, DOI 10.1172/JCI77084
   Mazzei L, 2016, BMC NEPHROL, V17, DOI 10.1186/s12882-016-0250-6
   Munkonda MN, 2018, J EXTRACELL VESICLES, V7, DOI 10.1080/20013078.2018.1432206
   Nangaku M, 2005, J AM SOC NEPHROL, V16, P1195, DOI 10.1681/ASN.2004121098
   Pavenstädt H, 2003, PHYSIOL REV, V83, P253, DOI 10.1152/physrev.00020.2002
   Pawar AS, 2015, OBESITY, V23, P399, DOI 10.1002/oby.20971
   Pisitkun T, 2006, MOL CELL PROTEOMICS, V5, P1760, DOI 10.1074/mcp.R600004-MCP200
   Prunotto M, 2013, J PROTEOMICS, V82, P193, DOI 10.1016/j.jprot.2013.01.012
   Reidy K, 2014, J CLIN INVEST, V124, P2333, DOI 10.1172/JCI72271
   Ristola M, 2014, CLIN SCI, V126, P315, DOI 10.1042/CS20130258
   Ruggiero C, 2011, AM J PHYSIOL-ENDOC M, V300, pE1047, DOI 10.1152/ajpendo.00666.2010
   Salih M, 2014, AM J PHYSIOL-RENAL, V306, pF1251, DOI 10.1152/ajprenal.00128.2014
   Sun YBY, 2015, KIDNEY INT, V88, P286, DOI 10.1038/ki.2015.121
   Sweetwyne MT, 2017, KIDNEY INT, V91, P1126, DOI 10.1016/j.kint.2016.10.036
   Szeto HH, 2017, J AM SOC NEPHROL, V28, P1437, DOI 10.1681/ASN.2016070761
   Szeto HH, 2016, KIDNEY INT, V90, P997, DOI 10.1016/j.kint.2016.06.013
   Szeto HH, 2015, AM J PHYSIOL-RENAL, V308, pF11, DOI 10.1152/ajprenal.00366.2014
   Thomas G, 2011, CLIN J AM SOC NEPHRO, V6, P2364, DOI 10.2215/CJN.02180311
   Ueda S, 2015, FREE RADICAL BIO MED, V87, P181, DOI 10.1016/j.freeradbiomed.2015.06.028
   Verma R, 2006, J CLIN INVEST, V116, P1346, DOI 10.1172/JCI27414
   VIBERTI G, 1994, JAMA-J AM MED ASSOC, V271, P275, DOI 10.1001/jama.271.4.275
   Wang DQ, 2014, PROTEOMICS, V14, P1922, DOI 10.1002/pmic.201300371
   Whaley-Connell AT, 2006, AM J PHYSIOL-RENAL, V291, pF1308, DOI 10.1152/ajprenal.00167.2006
   Wicks SE, 2016, BIOCHIMIE, V124, P65, DOI 10.1016/j.biochi.2015.08.001
   Wiggins RC, 2007, KIDNEY INT, V71, P1205, DOI 10.1038/sj.ki.5002222
   Zhao KS, 2004, J BIOL CHEM, V279, P34682, DOI 10.1074/jbc.M402999200
NR 48
TC 30
Z9 34
U1 2
U2 11
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD JUL
PY 2019
VL 317
IS 1
BP F12
EP F22
DI 10.1152/ajprenal.00399.2018
PG 11
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA IK5WE
UT WOS:000476655300002
PM 31042059
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Taher, R
   Sara, JD
   Heidari, B
   Toya, T
   Lerman, LO
   Lerman, A
AF Taher, Riad
   Sara, Jaskanwal D.
   Heidari, Behnam
   Toya, Takumi
   Lerman, Lilach O.
   Lerman, Amir
TI Metabolic syndrome is associated with peripheral endothelial dysfunction
   amongst men
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE metabolic syndrome; peripheral endothelial dysfunction; reactive
   hyperemia peripheral arterial tonometry; cardiovascular disease
ID INTERNATIONAL-DIABETES-FEDERATION; CARDIOVASCULAR EVENTS; WAIST
   CIRCUMFERENCE; HEART; PREVENTION; MORTALITY; CRITERIA; DISEASE; STRESS;
   ADULTS
AB Purpose: Metabolic syndrome (MetS) and peripheral endothelial dysfunction (PED) are both independently associated with an increased risk of cardiovascular disease (CVD). PED provides prognostic information beyond that provided by conventional risk factors. However, the association between MetS and PED remains uncertain. We evaluated the association between MetS and PED.
   Patients and methods: We performed a retrospective analysis of patients who were referred to Mayo Clinic between 2006 and 2014 for evaluation of chest pain and/or an assessment of CVD risk that included an assessment of PED measured with reactive hyperemia peripheral arterial tonometry. MetS was defined as the presence of at least 3 of the following: body mass index >= 25 kg/m(2), impaired fasting glucose or diabetes, high blood pressure or hypertension, hypertriglyceridemia, or low high-density lipoprotein cholesterol.
   Results: Six hundred seventy-eight patients were included (mean age 51.9 +/- 13.5 years, 418 (61.6%) women), of which 293 (43.2%) had PED, and 249 (36.7%) had MetS. In multivariable analyses adjusted for age, sex, CVD, smoking status, and elevated low-density lipoprotein, MetS was significantly associated with PED (Odds Ratio (OR) 2.06; P=0.0090). Of the individual MetS components, only being overweight and MetS range high-density lipoprotein had a similar association. After stratifying by sex, the association between MetS and PED persisted only in men (OR 3.16, P=0.0094).
   Conclusions: MetS is associated with PED in men undergoing an assessment of chest pain and/ or CVD risk. Identifying PED in individuals with MetS could provide an abridged assessment of risk, potentially allowing for earlier and more intensive management of risk factors.
C1 [Taher, Riad; Sara, Jaskanwal D.; Heidari, Behnam; Toya, Takumi; Lerman, Amir] Mayo Clin, Coll Med & Sci, Div Cardiovasc Dis, 200 1st St SW, Rochester, MN 55902 USA.
   [Lerman, Lilach O.] Mayo Clin, Coll Med & Sci, Div Nephrol & Hypertens, Dept Med, Rochester, MN USA.
C3 Mayo Clinic; Mayo Clinic
RP Lerman, A (corresponding author), Mayo Clin, Coll Med & Sci, Div Cardiovasc Dis, 200 1st St SW, Rochester, MN 55902 USA.
EM Lerman.amir@mayo.edu
RI Lerman, Lilach/M-4962-2017
OI Taher, Riad/0000-0002-7419-0498; Toya, Takumi/0000-0002-4681-2798
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Bi XY, 2019, NUTRITION, V57, P127, DOI 10.1016/j.nut.2018.05.016
   BJORNTORP P, 1985, ANN INTERN MED, V103, P994, DOI 10.7326/0003-4819-103-6-994
   Bonetti PO, 2003, ARTERIOSCL THROM VAS, V23, P168, DOI 10.1161/01.ATV.0000051384.43104.FC
   Ford ES, 2005, DIABETES CARE, V28, P2745, DOI 10.2337/diacare.28.11.2745
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Jacobs EJ, 2010, ARCH INTERN MED, V170, P1293, DOI 10.1001/archinternmed.2010.201
   Jellinger PS, 2017, ENDOCR PRACT, V23, P479, DOI 10.4158/EP171764.GL
   Koster A, 2008, AM J EPIDEMIOL, V167, P1465, DOI 10.1093/aje/kwn079
   Lawlor DA, 2006, DIABETOLOGIA, V49, P41, DOI 10.1007/s00125-005-0040-3
   Lerman A, 2005, CIRCULATION, V111, P363, DOI 10.1161/01.CIR.0000153339.27064.14
   Levey AS, 1999, ANN INTERN MED, V130, P461, DOI 10.7326/0003-4819-130-6-199903160-00002
   Lopes-Vicente WRP, 2017, DIABETOL METAB SYNDR, V9, DOI 10.1186/s13098-017-0286-1
   Lteif AA, 2005, CIRCULATION, V112, P32, DOI 10.1161/CIRCULATIONAHA.104.520130
   Martin EA, 2010, J AM COLL CARDIOL, V56, P1840, DOI 10.1016/j.jacc.2010.03.107
   Matsuzawa Y, 2015, J AM HEART ASSOC, V4, DOI 10.1161/JAHA.115.002270
   Matsuzawa Y, 2013, CIRC J, V77, P2807, DOI 10.1253/circj.CJ-13-0549
   Meigs James B, 2006, Expert Rev Endocrinol Metab, V1, P57, DOI 10.1586/17446651.1.1.57
   Murrow JR, 2012, J CLIN LIPIDOL, V6, P42, DOI 10.1016/j.jacl.2011.08.006
   Pi-Sunyer FX, 1998, OBES RES, V6, p51S
   RICHEDWARDS JW, 1995, NEW ENGL J MED, V332, P1758, DOI 10.1056/NEJM199506293322607
   Saely CH, 2006, DIABETES CARE, V29, P901, DOI 10.2337/diacare.29.04.06.dc05-2011
   Sattar N, 2008, LANCET, V371, P1927, DOI 10.1016/S0140-6736(08)60602-9
   Schorr M, 2018, BIOL SEX DIFFER, V9, DOI 10.1186/s13293-018-0189-3
   Scuteri A, 2015, EUR J PREV CARDIOL, V22, P486, DOI 10.1177/2047487314525529
   Strazzullo P, 2008, METABOLISM, V57, P355, DOI 10.1016/j.metabol.2007.10.010
   Topouchian J, 2018, J HYPERTENS, V36, P824, DOI 10.1097/HJH.0000000000001631
   Weisrock F, 2017, VASC MED, V22, P292, DOI 10.1177/1358863X17706752
   Westerweel PE, 2008, EUR HEART J, V29, P2808, DOI 10.1093/eurheartj/ehn431
   Whitlock G, 2009, LANCET, V373, P1083, DOI 10.1016/S0140-6736(09)60318-4
NR 30
TC 13
Z9 13
U1 0
U2 1
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABETES METAB SYNDR
JI Diabetes Metab. Syndr. Obes.
PY 2019
VL 12
BP 1035
EP 1045
DI 10.2147/DMSO.S204666
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA IJ2SQ
UT WOS:000475755600001
PM 31308718
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Michalakis, K
   Mintziori, G
   Kaprara, A
   Tarlatzis, BC
   Goulis, DG
AF Michalakis, Konstantinos
   Mintziori, Gesthimani
   Kaprara, Athina
   Tarlatzis, Basil C.
   Goulis, Dimitrios G.
TI The complex interaction between obesity, metabolic syndrome and
   reproductive axis: A narrative review
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Review
DE Metabolic syndrome; Obesity; Reproductive Axis; Hypogonadism;
   Subfertility
ID BODY-MASS INDEX; HORMONE-BINDING GLOBULIN; ANTI-MULLERIAN HORMONE;
   PLASMA GHRELIN LEVELS; INHIBIN-B LEVELS; MIDDLE-AGED MEN; NORMALIZES
   SERUM TESTOSTERONE; POLYCYSTIC-OVARY-SYNDROME; SOLUBLE LEPTIN RECEPTOR;
   GLUCAGON-LIKE PEPTIDE-1
AB The aim of this narrative review is to provide current evidence for the interaction between obesity, metabolic syndrome (MS) and reproductive axis. Gonadotropin-releasing hormone (GnRH) pulses and, consequently, normal function of reproductive (hypothalamus-pituitary-gonadal) axis depend on normal energy balance, which presupposes sufficient food intake, reasonable energy consumption and average thermoregulatory costs. In case of an energy imbalance, reproductive dysfunction may occur. In young women, excessive leanness is accompanied by puberty delay, whereas premature puberty might be a manifestation of obesity. In a similar way, obesity in men affects fertility. Excess adipose tissue results in increased conversion of testosterone to estradiol, which may lead to secondary hypogonadism through reproductive axis suppression. Moreover, oxidative stress at the level of the testicular micro-environment may result in decreased spermatogenesis and sperm damage. Products of the adipocyte, such as leptin, adiponectin and resistin, and gut peptides, such as ghrelin, are considered to be crucial in the interaction between energy balance and reproduction. Finally, an indirect evidence for the interplay between MS and reproductive axis is the fact that when treating components of one, parameters of the other can be improved as well. These therapeutic interventions include lifestyle modifications, pharmacological agents, such as sex hormone replacement therapy, and surgical procedures. Although many issues remain unclear, the elucidation of the complex interaction between MS and reproductive axis will have obvious clinical implications in the therapeutic approach of both entities. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Michalakis, Konstantinos] Univ Athens, Sch Med, Laikon Univ Hosp, Dept Internal Med 1, GR-10679 Athens, Greece.
   [Mintziori, Gesthimani; Kaprara, Athina; Tarlatzis, Basil C.; Goulis, Dimitrios G.] Aristotle Univ Thessaloniki, Sch Med, Dept Obstet & Gynecol 1, Unit Reprod Endocrinol, Thessaloniki, Greece.
C3 National & Kapodistrian University of Athens; Laiko General Hospital;
   Athens Medical School; Aristotle University of Thessaloniki
RP Goulis, DG (corresponding author), Papageorgiou Gen Hosp, Dept Obstet & Gynecol 1, Unit Reprod Endocrinol, Ring Rd, Thessaloniki 54601, Greece.
EM dimitrios.goulis@otenet.gr
RI Tarlatzis, Basil/M-6964-2013; Mintziori, Gesthimani/H-8491-2019; Goulis,
   Dimitrios/AAG-4589-2020
OI Goulis, Dimitrios/0000-0002-5005-1995
CR Agarwal A, 2009, UROLOGY, V73, P461, DOI 10.1016/j.urology.2008.07.053
   Agarwal SK, 1999, J CLIN ENDOCR METAB, V84, P1072, DOI 10.1210/jc.84.3.1072
   Aggerholm AS, 2008, FERTIL STERIL, V90, P619, DOI 10.1016/j.fertnstert.2007.07.1292
   Ahima RS, 2000, ANNU REV PHYSIOL, V62, P413, DOI 10.1146/annurev.physiol.62.1.413
   Akin F, 2009, EUR J INTERN MED, V20, P162, DOI 10.1016/j.ejim.2007.09.023
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Allen NE, 2002, CANCER CAUSE CONTROL, V13, P353, DOI 10.1023/A:1015238102830
   Archanco M, 2007, J HISTOCHEM CYTOCHEM, V55, P1027, DOI 10.1369/jhc.6A7128.2007
   Arikan S, 2010, GYNECOL ENDOCRINOL, V26, P161, DOI 10.3109/09513590903247816
   Ariyasu H, 2001, J CLIN ENDOCR METAB, V86, P4753, DOI 10.1210/jc.86.10.4753
   Arrabal-Polo MA, 2012, ACTAS UROL ESP, V36, P222, DOI 10.1016/j.acuro.2011.07.012
   Arslanian S, 1998, METABOLISM, V47, P309, DOI 10.1016/S0026-0495(98)90262-1
   Aversa A, 2010, J ENDOCRINOL INVEST, V33, P776, DOI [10.3275/6903, 10.1007/BF03350341]
   Aversa A, 2010, J SEX MED, V7, P3495, DOI 10.1111/j.1743-6109.2010.01931.x
   Bajos N, 2010, BRIT MED J, V340, DOI 10.1136/bmj.c2573
   Baker HWG, 1998, ENDOCRIN METAB CLIN, V27, P831
   Baldelli R, 2002, ANN MED, V34, P5, DOI 10.1080/078538902317338599
   Barash IA, 1996, ENDOCRINOLOGY, V137, P3144, DOI 10.1210/en.137.7.3144
   Barreiro ML, 2003, BIOL REPROD, V68, P1631, DOI 10.1095/biolreprod.102.008862
   Bastounis EA, 1998, EUR SURG RES, V30, P43, DOI 10.1159/000008556
   Batista CMDS, 2007, DIABETES, V56, P1655, DOI 10.2337/db06-1506
   Batterham RL, 2002, NATURE, V418, P650, DOI 10.1038/nature00887
   BERGH C, 1993, FERTIL STERIL, V59, P323
   Beydoun HA, 2012, MATURITAS, V71, P55, DOI 10.1016/j.maturitas.2011.10.010
   Bik W, 2007, GYNECOL ENDOCRINOL, V23, P325, DOI 10.1080/09513590701260169
   Bluher Susann, 2007, Curr Opin Endocrinol Diabetes Obes, V14, P458, DOI 10.1097/MED.0b013e3282f1cfdc
   Bozaoglu K, 2010, J CLIN ENDOCR METAB, V95, P2476, DOI 10.1210/jc.2010-0042
   Brand JS, 2011, INT J EPIDEMIOL, V40, P189, DOI 10.1093/ije/dyq158
   Bray George A., 1997, Human Reproduction (Oxford), V12, P26
   Brinkoetter M, 2011, AM J PHYSIOL-ENDOC M, V301, pE99, DOI 10.1152/ajpendo.00146.2011
   Budak E, 2006, FERTIL STERIL, V85, P1563, DOI 10.1016/j.fertnstert.2005.09.065
   Burnett MS, 2006, J CLIN ENDOCR METAB, V91, P64, DOI 10.1210/jc.2005-1653
   Cabler S, 2010, ASIAN J ANDROL, V12, P480, DOI 10.1038/aja.2010.38
   Caminos JE, 2008, ENDOCRINOLOGY, V149, P3390, DOI 10.1210/en.2007-1582
   Caminos JE, 2005, J CLIN ENDOCR METAB, V90, P4276, DOI 10.1210/jc.2004-0930
   Campos DB, 2008, INT J OBESITY, V32, P223, DOI 10.1038/sj.ijo.0803719
   Cervero A, 2005, REPROD BIOMED ONLINE, V10, P217, DOI 10.1016/S1472-6483(10)60943-1
   Chabrolle C, 2009, FERTIL STERIL, V92, P1988, DOI 10.1016/j.fertnstert.2008.09.008
   Chang PJ, 2009, AUST NZ J OBSTET GYN, V49, P689, DOI 10.1111/j.1479-828X.2009.01097.x
   Chavarro JE, 2010, FERTIL STERIL, V93, P2222, DOI 10.1016/j.fertnstert.2009.01.100
   Chen Dong-mei, 2012, Zhonghua Fu Chan Ke Za Zhi, V47, P115
   Chen HY, 2004, ENDOCRINOLOGY, V145, P2607, DOI 10.1210/en.2003-1596
   Chen XL, 2010, EUR J OBSTET GYN R B, V149, P72, DOI 10.1016/j.ejogrb.2009.11.018
   Chou SH, 2011, P NATL ACAD SCI USA, V108, P6585, DOI 10.1073/pnas.1015674108
   Chughtai B, 2011, CURR OPIN UROL, V21, P514, DOI 10.1097/MOU.0b013e32834b8681
   Cioffi JA, 1997, MOL HUM REPROD, V3, P467, DOI 10.1093/molehr/3.6.467
   CLARK AM, 1995, HUM REPROD, V10, P2705, DOI 10.1093/oxfordjournals.humrep.a135772
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cohen MA, 2003, J CLIN ENDOCR METAB, V88, P4696, DOI 10.1210/jc.2003-030421
   Corona G, 2011, J SEX MED, V8, P272, DOI 10.1111/j.1743-6109.2010.01991.x
   Craig JA, 2005, MOL CELL ENDOCRINOL, V229, P141, DOI 10.1016/j.mce.2004.08.008
   CRAVE JC, 1995, J CLIN ENDOCR METAB, V80, P2057, DOI 10.1210/jc.80.7.2057
   Cummings DE, 2006, PHYSIOL BEHAV, V89, P71, DOI 10.1016/j.physbeh.2006.05.022
   Cummings DE, 2004, AM J PHYSIOL-ENDOC M, V287, pE297, DOI 10.1152/ajpendo.00582.2003
   Cummings DE, 2001, DIABETES, V50, P1714, DOI 10.2337/diabetes.50.8.1714
   Cummings DE, 2002, NEW ENGL J MED, V346, P1623, DOI 10.1056/NEJMoa012908
   Cunningham MJ, 1999, BIOL REPROD, V60, P216, DOI 10.1095/biolreprod60.2.216
   Dalamaga M, 2012, ENDOCR REV, V33, P547, DOI 10.1210/er.2011-1015
   Dardeno TA, 2010, FRONT NEUROENDOCRIN, V31, P377, DOI 10.1016/j.yfrne.2010.06.002
   Date Y, 2000, ENDOCRINOLOGY, V141, P4255, DOI 10.1210/en.141.11.4255
   de Boer H, 2005, DIABETES OBES METAB, V7, P211, DOI 10.1111/j.1463-1326.2004.00397.x
   De Pergola G, 2009, J ENDOCRINOL INVEST, V32, P98, DOI 10.1007/BF03345694
   De Pergola G, 2006, OBESITY, V14, P1954, DOI 10.1038/oby.2006.228
   Dhindsa S, 2010, DIABETES CARE, V33, P1186, DOI 10.2337/dc09-1649
   Donato J, 2011, NEUROENDOCRINOLOGY, V93, P9, DOI 10.1159/000322472
   Druce MR, 2005, INT J OBESITY, V29, P1130, DOI 10.1038/sj.ijo.0803001
   Einhorn Daniel, 2003, Endocr Pract, V9, P237
   Esposito K, 2004, JAMA-J AM MED ASSOC, V291, P2978, DOI 10.1001/jama.291.24.2978
   Evans JJ, 2012, HUM REPROD UPDATE, V18, P313, DOI 10.1093/humupd/dms004
   Farooqi IS, 2002, J CLIN INVEST, V110, P1093, DOI 10.1172/JCI200215693
   Fejes I, 2005, ANDROLOGIA, V37, P155, DOI 10.1111/j.1439-0272.2005.00671.x
   Fernandez-Fernandez R, 2006, MOL CELL ENDOCRINOL, V254, P127, DOI 10.1016/j.mce.2006.04.026
   Fernández-Fernández R, 2005, ENDOCRINOLOGY, V146, P3018, DOI 10.1210/en.2004-1622
   Forbes S, 2009, NEUROSCI LETT, V460, P143, DOI 10.1016/j.neulet.2009.05.060
   Foresta C, 2009, CLIN ENDOCRINOL, V71, P722, DOI 10.1111/j.1365-2265.2009.03549.x
   Freeman EW, 2007, FERTIL STERIL, V87, P101, DOI 10.1016/j.fertnstert.2006.05.074
   Freeman EW, 2010, MENOPAUSE, V17, P718, DOI [10.1097/gme.0b013e3181cec85d, 10.1097/gme.0b013e3181db9f8b]
   FRISCH RE, 1985, PERSPECT BIOL MED, V28, P611
   Gale SM, 2004, J NUTR, V134, P295, DOI 10.1093/jn/134.2.295
   Gaytan F, 2004, J CLIN ENDOCR METAB, V89, P400, DOI 10.1210/jc.2003-031375
   Gerrits EG, 2003, OBES SURG, V13, P378, DOI 10.1381/096089203765887697
   GIAGULLI VA, 1994, J CLIN ENDOCR METAB, V79, P997, DOI 10.1210/jc.79.4.997
   Gibson W, 2010, METABOLISM, V59, P841, DOI 10.1016/j.metabol.2009.09.033
   Gil-Campos M, 2004, CLIN NUTR, V23, P963, DOI 10.1016/j.clnu.2004.04.010
   Golden SH, 2004, AM J EPIDEMIOL, V160, P540, DOI 10.1093/aje/kwh250
   Goralski KB, 2007, J BIOL CHEM, V282, P28175, DOI 10.1074/jbc.M700793200
   Goulis DG, 2008, GYNECOL ENDOCRINOL, V24, P33, DOI 10.1080/09513590701582273
   Gracia CR, 2005, MENOPAUSE, V12, P559, DOI 10.1097/01.gme.0000172268.24949.94
   GRODSTEIN F, 1994, EPIDEMIOLOGY, V5, P247, DOI 10.1097/00001648-199403000-00016
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Gündüz MI, 2004, ASIAN J ANDROL, V6, P355
   Gutman G, 2009, FERTIL STERIL, V91, P1837, DOI 10.1016/j.fertnstert.2008.02.006
   Gutzwiller JP, 1999, GUT, V44, P81, DOI 10.1136/gut.44.1.81
   Haider A, 2010, EXP CLIN ENDOCR DIAB, V118, P167, DOI 10.1055/s-0029-1202774
   Halawaty S, 2010, J OBSTET GYNAECOL CA, V32, P687, DOI 10.1016/S1701-2163(16)34573-X
   Hammoud A, 2009, J CLIN ENDOCR METAB, V94, P1329, DOI 10.1210/jc.2008-1598
   Hammoud AO, 2008, FERTIL STERIL, V90, P897, DOI 10.1016/j.fertnstert.2008.08.026
   Hammoud AO, 2008, FERTIL STERIL, V90, P2222, DOI 10.1016/j.fertnstert.2007.10.011
   Hardie L, 1997, CLIN ENDOCRINOL, V47, P101, DOI 10.1046/j.1365-2265.1997.2441017.x
   Hassan MAM, 2004, FERTIL STERIL, V81, P384, DOI 10.1016/j.fertnstert.2003.06.027
   Havel PJ, 2001, EXP BIOL MED, V226, P963, DOI 10.1177/153537020122601102
   Heidemann C, 2008, ANN INTERN MED, V149, P307, DOI 10.7326/0003-4819-149-5-200809020-00005
   Heufelder AE, 2009, J ANDROL, V30, P726, DOI 10.2164/jandrol.108.007005
   Heymsfield SB, 1999, JAMA-J AM MED ASSOC, V282, P1568, DOI 10.1001/jama.282.16.1568
   Hill JW, 2008, AM J PHYSIOL-ENDOC M, V294, pE827, DOI 10.1152/ajpendo.00670.2007
   Holcomb IN, 2000, EMBO J, V19, P4046, DOI 10.1093/emboj/19.15.4046
   Hollmann M, 1996, HUM REPROD, V11, P1884
   Hug C, 2004, P NATL ACAD SCI USA, V101, P10308, DOI 10.1073/pnas.0403382101
   Ishikawa M, 2005, CLIN CANCER RES, V11, P466
   Isidori AM, 2005, CLIN ENDOCRINOL, V63, P280, DOI 10.1111/j.1365-2265.2005.02339.x
   Isidori AM, 1999, J CLIN ENDOCR METAB, V84, P3673, DOI 10.1210/jc.84.10.3673
   Jain A, 2007, J CLIN ENDOCR METAB, V92, P2468, DOI 10.1210/jc.2006-2274
   Jakubowicz DJ, 1997, J CLIN ENDOCR METAB, V82, P556, DOI 10.1210/jc.82.2.556
   Jensen TK, 2004, FERTIL STERIL, V82, P863, DOI 10.1016/j.fertnstert.2004.03.056
   Jones TH, 2011, DIABETES CARE, V34, P828, DOI 10.2337/dc10-1233
   Kalinchenko SY, 2010, CLIN ENDOCRINOL, V73, P602, DOI 10.1111/j.1365-2265.2010.03845.x
   Kaplan SA, 2006, J UROLOGY, V176, P1524, DOI 10.1016/j.juro.2006.06.003
   Kasturi SS, 2008, J ANDROL, V29, P251, DOI 10.2164/jandrol.107.003731
   Kaukua J, 2003, OBES RES, V11, P689, DOI 10.1038/oby.2003.98
   Keim NL, 1998, AM J CLIN NUTR, V68, P794, DOI 10.1093/ajcn/68.4.794
   KIRSCHNER MA, 1990, J CLIN ENDOCR METAB, V70, P473, DOI 10.1210/jcem-70-2-473
   Kissebah AH, 2000, P NATL ACAD SCI USA, V97, P14478, DOI 10.1073/pnas.97.26.14478
   Klöting N, 2010, AM J PHYSIOL-ENDOC M, V299, pE506, DOI 10.1152/ajpendo.00586.2009
   Koloszár S, 2005, ARCH ANDROLOGY, V51, P299, DOI 10.1080/01485010590919701
   Korhonen S, 2003, FERTIL STERIL, V79, P1327, DOI 10.1016/S0015-0282(03)00347-9
   Kort HI, 2006, J ANDROL, V27, P450, DOI 10.2164/jandrol.05124
   Laaksonen DE, 2005, J CLIN ENDOCR METAB, V90, P712, DOI 10.1210/jc.2004-0970
   Laaksonen DE, 2003, EUR J ENDOCRINOL, V149, P601, DOI 10.1530/eje.0.1490601
   Lagaly DV, 2008, MOL CELL ENDOCRINOL, V284, P38, DOI 10.1016/j.mce.2008.01.007
   Lake JK, 1997, INT J OBESITY, V21, P432, DOI 10.1038/sj.ijo.0800424
   Lambert-Messerlian G, 2011, HUM REPROD, V26, P2518, DOI 10.1093/humrep/der095
   Lammert A, 2001, BIOCHEM BIOPH RES CO, V283, P982, DOI 10.1006/bbrc.2001.4885
   Laplante M, 2003, DIABETES, V52, P291, DOI 10.2337/diabetes.52.2.291
   Larsen SH, 2007, INT J OBESITY, V31, P1189, DOI 10.1038/sj.ijo.0803604
   Law DCG, 2007, HUM REPROD, V22, P414, DOI 10.1093/humrep/de1400
   Lee JH, 2006, J CLIN ENDOCR METAB, V91, P2605, DOI 10.1210/jc.2005-1545
   Lee JH, 2003, J CLIN ENDOCR METAB, V88, P4848, DOI 10.1210/jc.2003-030519
   Lee MJ, 2009, AM J PHYSIOL-ENDOC M, V296, pE1230, DOI 10.1152/ajpendo.90927.2008
   Lee YH, 2011, METABOLISM, V60, P1664, DOI 10.1016/j.metabol.2011.04.008
   LEENEN R, 1994, J CLIN ENDOCR METAB, V78, P1515, DOI 10.1210/jc.78.6.1515
   Licinio J, 2004, P NATL ACAD SCI USA, V101, P4531, DOI 10.1073/pnas.0308767101
   Liu X, 2012, GUT
   Lord E, 2005, J ANIM SCI, V83, P565
   Loves S, 2008, EUR J ENDOCRINOL, V158, P741, DOI 10.1530/EJE-07-0663
   Maeda K, 1996, BIOCHEM BIOPH RES CO, V221, P286, DOI 10.1006/bbrc.1996.0587
   Maggard MA, 2008, JAMA-J AM MED ASSOC, V300, P2286, DOI 10.1001/jama.2008.641
   Maggio M, 2007, AM J PHYSIOL-ENDOC M, V292, pE353, DOI 10.1152/ajpendo.00339.2006
   Magkos F, 2011, METABOLISM, V60, P749, DOI 10.1016/j.metabol.2010.09.011
   Magnusdottir EV, 2005, HUM REPROD, V20, P208, DOI 10.1093/humrep/deh569
   Mantzoros C, 2004, J CLIN ENDOCR METAB, V89, P1102, DOI 10.1210/jc.2003-031804
   Mantzoros CS, 2012, DIABETES METAB J, V36, P181, DOI 10.4093/dmj.2012.36.3.181
   Mantzoros CS, 2011, AM J PHYSIOL-ENDOC M, V301, pE567, DOI 10.1152/ajpendo.00315.2011
   Martini AC, 2006, ENDOCRINOLOGY, V147, P2374, DOI 10.1210/en.2005-1422
   Matkovic V, 1997, J CLIN ENDOCR METAB, V82, P3239, DOI 10.1210/jc.82.10.3239
   Meier U, 2004, CLIN CHEM, V50, P1511, DOI 10.1373/clinchem.2004.032482
   Merhi ZO, 2008, FERTIL STERIL, V90, P221, DOI 10.1016/j.fertnstert.2007.05.073
   Metwally M, 2007, OBES REV, V8, P515, DOI 10.1111/j.1467-789X.2007.00406.x
   Michalakis K, 2007, CANCER EPIDEM BIOMAR, V16, P308, DOI 10.1158/1055-9965.EPI-06-0621
   Michalakis K, 2012, OBES SURG, V22, P1648, DOI 10.1007/s11695-012-0698-9
   Mohr BA, 2006, EUR J ENDOCRINOL, V155, P443, DOI 10.1530/eje.1.02241
   Morash BA, 2004, NEUROENDOCRINOLOGY, V79, P149, DOI 10.1159/000077273
   Morash BA, 2002, FEBS LETT, V526, P26, DOI 10.1016/S0014-5793(02)03108-3
   Moreno-Aliaga MJ, 2010, P NUTR SOC, V69, P324, DOI 10.1017/S0029665110001801
   Muccioli G, 2011, PEPTIDES, V32, P2514, DOI 10.1016/j.peptides.2011.10.020
   Muller M, 2005, J CLIN ENDOCR METAB, V90, P2618, DOI 10.1210/jc.2004-1158
   Murakami N, 2002, J ENDOCRINOL, V174, DOI 10.1677/joe.0.1740283
   Musso C, 2005, METABOLISM, V54, P255, DOI 10.1016/j.metabol.2004.08.021
   Nagatani S, 1998, NEUROENDOCRINOLOGY, V67, P370, DOI 10.1159/000054335
   Nakazato M, 2001, NATURE, V409, P194, DOI 10.1038/35051587
   Nishizawa H, 2002, DIABETES, V51, P2734, DOI 10.2337/diabetes.51.9.2734
   Niskanen L, 2004, DIABETES OBES METAB, V6, P208, DOI 10.1111/j.1462-8902.2004.00335.x
   Niswender KD, 2001, NATURE, V413, P794, DOI 10.1038/35101657
   Nogueiras R, 2004, J CELL SCI, V117, P3247, DOI 10.1242/jcs.01196
   Ocón-Grove OM, 2008, REPRODUCTION, V136, P627, DOI 10.1530/REP-07-0446
   Otto B, 2001, EUR J ENDOCRINOL, V145, pR5
   Ouchi N, 2006, TRENDS CARDIOVAS MED, V16, P141, DOI 10.1016/j.tcm.2006.03.001
   Pan HY, 2010, DIABETES RES CLIN PR, V88, P29, DOI 10.1016/j.diabres.2010.01.013
   Panidis D, 2006, FERTIL STERIL, V85, P1778, DOI 10.1016/j.fertnstert.2005.11.044
   Pasceri V, 1999, CIRCULATION, V100, P2124, DOI 10.1161/01.CIR.100.21.2124
   Pasquali R, 2000, J CLIN ENDOCR METAB, V85, P2767, DOI 10.1210/jc.85.8.2767
   Pasquali R, 1997, INT J OBESITY, V21, P1, DOI 10.1038/sj.ijo.0800351
   Patel SM, 2009, J CLIN ENDOCR METAB, V94, P4776, DOI 10.1210/jc.2009-0740
   Pavlovich CP, 2001, J UROLOGY, V165, P837, DOI 10.1016/S0022-5347(05)66540-8
   Payette C, 2009, METABOLISM, V58, P1593, DOI 10.1016/j.metabol.2009.05.011
   Petridou E, 2003, J CLIN ENDOCR METAB, V88, P993, DOI 10.1210/jc.2002-021209
   Petzel Martin, 2007, Biomedical Papers (Olomouc), V151, P195
   Pisto P, 2011, METABOLISM, V60, P1515, DOI 10.1016/j.metabol.2011.03.009
   Psilopanagioti A, 2009, NEUROENDOCRINOLOGY, V89, P38, DOI 10.1159/000151396
   Pulzer F, 2001, METABOLISM, V50, P1141, DOI 10.1053/meta.2001.26746
   Rao SR, 2011, GENDER MED, V8, P300, DOI 10.1016/j.genm.2011.05.007
   Reis LO, 2010, INT J ANDROL, V33, P736, DOI 10.1111/j.1365-2605.2009.01017.x
   Repaci A, 2011, MOL CELL ENDOCRINOL, V340, P70, DOI 10.1016/j.mce.2011.02.022
   Reverchon M, 2012, HUM REPROD, V27, P1790, DOI 10.1093/humrep/des089
   RICHEDWARDS JW, 1994, AM J OBSTET GYNECOL, V171, P171, DOI 10.1016/0002-9378(94)90465-0
   Rijkelijkhuizen JM, 2010, METABOLISM, V59, P502, DOI 10.1016/j.metabol.2009.07.039
   Robeva R, 2012, ANDROLOGIA, V44, P329, DOI 10.1111/j.1439-0272.2011.01185.x
   Robker RL, 2009, J CLIN ENDOCR METAB, V94, P1533, DOI 10.1210/jc.2008-2648
   Rochester D, 2009, FERTIL STERIL, V92, P1410, DOI 10.1016/j.fertnstert.2008.08.025
   Rosmond R, 1996, OBES RES, V4, P245, DOI 10.1002/j.1550-8528.1996.tb00542.x
   Roth MY, 2008, NAT CLIN PRACT ENDOC, V4, P415, DOI 10.1038/ncpendmet0844
   Saad F, 2008, ANDROLOGIA, V40, P44, DOI 10.1111/j.1439-0272.2008.00807.x
   Sahmay S, 2012, ARCH GYNECOL OBSTET, V286, P661, DOI 10.1007/s00404-012-2363-x
   SALERA M, 1982, J CLIN ENDOCR METAB, V55, P329, DOI 10.1210/jcem-55-2-329
   Samara-Boustani D, 2012, EUR J ENDOCRINOL, V166, P307, DOI 10.1530/EJE-11-0670
   Santoro N, 2005, J CLIN ENDOCR METAB, V90, P4836, DOI 10.1210/jc.2004-2063
   Santoro N, 2004, J CLIN ENDOCR METAB, V89, P2622, DOI 10.1210/jc.2003-031578
   Savopoulos C, 2011, MATURITAS, V70, P322, DOI 10.1016/j.maturitas.2011.09.002
   SCHNEIDER G, 1979, J CLIN ENDOCR METAB, V48, P633, DOI 10.1210/jcem-48-4-633
   Schoeller DA, 1997, J CLIN INVEST, V100, P1882, DOI 10.1172/JCI119717
   Sell H, 2010, J CLIN ENDOCR METAB, V95, P2892, DOI 10.1210/jc.2009-2374
   Sentinelli F, 2002, DIABETES, V51, P860, DOI 10.2337/diabetes.51.3.860
   Sermondade N, 2012, ARCH INTERN MED, V172, P440, DOI 10.1001/archinternmed.2011.1382
   SHAFIK A, 1981, BRIT J UROL, V53, P50, DOI 10.1111/j.1464-410X.1981.tb03128.x
   Skalba P, 2011, EUR J OBSTET GYN R B, V158, P254, DOI 10.1016/j.ejogrb.2011.06.006
   Somani B, 2010, BJU INT, V106, P688, DOI 10.1111/j.1464-410X.2009.09145.x
   Sowers MR, 2010, ANN NY ACAD SCI, V1204, P95, DOI 10.1111/j.1749-6632.2010.05523.x
   Steppan CM, 2001, NATURE, V409, P307, DOI 10.1038/35053000
   Stewart TM, 2009, HUM REPROD, V24, P1561, DOI 10.1093/humrep/dep075
   Stofkova A, 2010, Endocr Regul, V44, P25
   STRAIN GW, 1982, METABOLISM, V31, P871, DOI 10.1016/0026-0495(82)90175-5
   Su HI, 2008, MENOPAUSE, V15, P857, DOI 10.1097/gme.0b013e318165981e
   Sudi KM, 2000, METABOLISM, V49, P890, DOI 10.1053/meta.2000.6736
   Svartberg J, 2004, EUR J EPIDEMIOL, V19, P657, DOI 10.1023/B:EJEP.0000036809.30558.8f
   Tan BK, 2010, DIABETES, V59, P3023, DOI 10.2337/db10-0124
   Tan BK, 2009, DIABETES, V58, P1971, DOI 10.2337/db08-1528
   Teerds KJ, 2011, HUM REPROD UPDATE, V17, P667, DOI 10.1093/humupd/dmr017
   Teitelman M, 2006, OBES SURG, V16, P1457, DOI 10.1381/096089206778870148
   Tönjes A, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013911
   Tomas E, 2002, P NATL ACAD SCI USA, V99, P16309, DOI 10.1073/pnas.222657499
   Tough SC, 2010, J OBSTET GYNAECOL CA, V32, P1153, DOI 10.1016/S1701-2163(16)34739-9
   Toulis KA, 2009, HUM REPROD UPDATE, V15, P297, DOI 10.1093/humupd/dmp006
   Tschöp M, 2000, NATURE, V407, P908, DOI 10.1038/35038090
   Turton MD, 1996, NATURE, V379, P69, DOI 10.1038/379069a0
   Twigg J, 1998, HUM REPROD, V13, P1429, DOI 10.1093/humrep/13.6.1429
   VERMEULEN A, 1993, J CLIN ENDOCR METAB, V76, P1140, DOI 10.1210/jc.76.5.1140
   VICTOR A, 1987, GASTROENTEROL CLIN N, V16, P483
   Vincent HK, 2007, DIABETES OBES METAB, V9, P813, DOI 10.1111/j.1463-1326.2007.00692.x
   Wan Zhao-Hui, 2010, Zhonghua Nan Ke Xue, V16, P510
   Wang C, 2011, DIABETES CARE, V34, P1669, DOI 10.2337/dc10-2339
   Wei EK, 2005, JNCI-J NATL CANCER I, V97, P1688, DOI 10.1093/jnci/dji376
   Weinberg ME, 2006, METABOLISM, V55, P1473, DOI 10.1016/j.metabol.2006.06.017
   Westerterp-Plantenga MS, 2001, AM J CLIN NUTR, V74, P426
   Wilkinson M, 2005, NEUROENDOCRINOLOGY, V81, P19, DOI 10.1159/000084871
   Winters SJ, 2006, J ANDROL, V27, P560, DOI 10.2164/jandrol.05193
   Wise LA, 2010, HUM REPROD, V25, P253, DOI 10.1093/humrep/dep360
   Wittamer V, 2003, J EXP MED, V198, P977, DOI 10.1084/jem.20030382
   Wolfe BE, 2004, CLIN ENDOCRINOL, V61, P332, DOI 10.1111/j.1365-2265.2004.02101.x
   Wren AM, 2007, GASTROENTEROLOGY, V132, P2116, DOI 10.1053/j.gastro.2007.03.048
   Wynne K, 2006, INT J OBESITY, V30, P1729, DOI 10.1038/sj.ijo.0803344
   Yamauchi J, 2008, METABOLISM, V57, P149, DOI 10.1016/j.metabol.2007.08.018
   Yang RZ, 2006, AM J PHYSIOL-ENDOC M, V290, pE1253, DOI 10.1152/ajpendo.00572.2004
   Yaylali GF, 2010, INT J IMPOT RES, V22, P220, DOI 10.1038/ijir.2010.7
   Yilmaz N, 2009, J WOMENS HEALTH, V18, P633, DOI 10.1089/jwh.2008.1057
   Zambon JP, 2010, SAO PAULO MED J, V128, P137, DOI 10.1590/S1516-31802010000300006
   Zhang J, 2011, GYNECOL ENDOCRINOL, V27, P982, DOI 10.3109/09513590.2011.569794
   Zigman JM, 2003, ENDOCRINOLOGY, V144, P3749, DOI 10.1210/en.2003-0241
   Zumoff B, 2003, METABOLISM, V52, P1126, DOI 10.1016/S0026-0495(03)00186-0
NR 258
TC 221
Z9 244
U1 2
U2 108
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD APR
PY 2013
VL 62
IS 4
BP 457
EP 478
DI 10.1016/j.metabol.2012.08.012
PG 22
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 125HL
UT WOS:000317530800001
PM 22999785
DA 2025-06-11
ER

PT J
AU Cardinali, DP
   Pagano, ES
   Bernasconi, PAS
   Reynoso, R
   Scacchi, P
AF Cardinali, Daniel P.
   Pagano, Eleonora S.
   Scacchi Bernasconi, Pablo A.
   Reynoso, Roxana
   Scacchi, Pablo
TI Disrupted chronobiology of sleep and cytoprotection in obesity: possible
   therapeutic value of melatonin
SO NEUROENDOCRINOLOGY LETTERS
LA English
DT Review
DE sleep; metabolic syndrome; diabetes; obesity; neuroimmunology;
   melatonin; cytokines; circadian rhythms; inflammation; free radicals
ID HIGH-FAT DIET; CIRCADIAN-RHYTHMS; BLOOD-PRESSURE; GENE-EXPRESSION; ORAL
   MELATONIN; BODY-WEIGHT; METABOLIC SYNDROME; OXIDATIVE STRESS;
   GROWTH-HORMONE; LIPID PROFILE
AB From a physiological perspective the sleep-wake cycle can be envisioned as a sequence of three physiological states (wakefulness, non-rapid eye movement, NREM, sleep and REM sleep) which are defined by a particular neuroendocrine-immune profile regulating the metabolic balance, body weight and inflammatory responses. Sleep deprivation and circadian disruption in contemporary "24/7 Society" lead to the predominance of pro-orexic and proinflammatory mechanisms that contribute to a pandemic metabolic syndrome (MS) including obesity, diabetes and atherosclerotic disease. Thus, a successful management of MS may require a drug that besides antagonizing the trigger factors of MS could also correct a disturbed sleep-wake rhythm. This review deals with the analysis of the therapeutic validity of melatonin in MS. Melatonin is an effective chronobiotic agent changing the phase and amplitude of the sleep/wake rhythm and having cytoprotective and immunomodulatory properties useful to prevent a number of MS sequels. Several studies support that melatonin can prevent hyperadiposity in animal models of obesity. Melatonin at a low dose (2-5 mg/day) has been used for improving sleep in patients with insomnia and circadian rhythm sleep disorders. More recently, attention has been focused on the development of potent melatonin analogs with prolonged effects (ramelteon, agomelatine, tasimelteon, TK 301). In clinical trials these analogs were employed in doses considerably higher than those usually employed for melatonin. In view that the relative potencies of the analogs are higher than that of the natural compound, clinical trials employing melatonin doses in the range of 50-100 mg/day are needed to assess its therapeutic value in MS.
C1 [Cardinali, Daniel P.] Pontificia Univ Catolica Argentina, UCA, Fac Ciencias Med, Dept Docencia & Invest, Buenos Aires, DF, Argentina.
C3 Pontificia Universidad Catolica Argentina
RP Cardinali, DP (corresponding author), Pontificia Univ Catolica Argentina, UCA, Fac Ciencias Med, Dept Docencia & Invest, Av Alicia Moreau de Justo 1500,4 Piso,C1107AFD, Buenos Aires, DF, Argentina.
EM danielcardinali@uca.edu.ar
FU Agencia Nacional de Promocion Cientifica y Tecnologica, Argentina [PICT
   2007-01045]; University of Buenos Aires [M006]; Argentine Research
   Council (CONICET); University of Buenos Aires; CONICET
FX Studies in authors' laboratories were supported by grants from the
   Agencia Nacional de Promocion Cientifica y Tecnologica, Argentina (PICT
   2007-01045) and the University of Buenos Aires (M006). DPC is a Research
   Career Awardee from the Argentine Research Council (CONICET) and
   Professor Emeritus, University of Buenos Aires. ESP and PS are Research
   Career Awardees from CONICET.
CR Castroviejo DA, 2011, CURR TOP MED CHEM, V11, P221
   Agil A, 2011, J PINEAL RES, V50, P207, DOI 10.1111/j.1600-079X.2010.00830.x
   Allan Hobson J., 1969, Arch. Gen. Psychiatry, V26, P644, DOI [DOI 10.1001/ARCHPSYC.1969.01740140118016, 10.1001/archpsyc.1969.01740140118016]
   [Anonymous], 2005, MMWR Morb Mortal Wkly Rep, P933
   [Anonymous], NEUROIMMUNOLOGY SLEE
   [Anonymous], J PINEAL RE IN PRESS
   Arendt J, 1997, J BIOL RHYTHM, V12, P604, DOI 10.1177/074873049701200616
   Bartness TJ, 2002, EXP BIOL MED, V227, P363, DOI 10.1177/153537020222700601
   Bass J, 2010, SCIENCE, V330, P1349, DOI 10.1126/science.1195027
   Beersma D G, 1998, Sleep Med Rev, V2, P31, DOI 10.1016/S1087-0792(98)90052-1
   Benítez-King G, 2006, J PINEAL RES, V40, P1, DOI 10.1111/j.1600-079X.2005.00282.x
   Berger J, 2008, PATHOL BIOL, V56, P286, DOI 10.1016/j.patbio.2007.10.001
   Beynon AL, 2010, CHRONOBIOL INT, V27, P1546, DOI 10.3109/07420528.2010.501927
   Blanco M, 2004, REV NEUROLOGIA, V39, P115, DOI 10.33588/rn.3902.2003649
   Bollinger T, 2010, GERONTOLOGY, V56, P574, DOI 10.1159/000281827
   Bonnefont X, 2010, J NEUROENDOCRINOL, V22, P209, DOI 10.1111/j.1365-2826.2010.01955.x
   Borbely A A, 1982, Hum Neurobiol, V1, P195
   Born J, 1997, J IMMUNOL, V158, P4454
   Bremer AA, 2011, CTS-CLIN TRANSL SCI, V4, P243, DOI 10.1111/j.1752-8062.2011.00298.x
   Bryant PA, 2004, NAT REV IMMUNOL, V4, P457, DOI 10.1038/nri1369
   Buijs RM, 2006, PROG BRAIN RES, V153, P341, DOI 10.1016/S0079-6123(06)53020-1
   Cagnacci A, 2005, AM J HYPERTENS, V18, P1614, DOI 10.1016/j.amjhyper.2005.05.008
   Cano P, 2008, ENDOCRINE, V33, P118, DOI 10.1007/s12020-008-9066-x
   Cano P, 2009, OBESITY, V17, P1866, DOI 10.1038/oby.2009.200
   Cardinali D. P., 1998, BIOMED REV, V9, P47
   Cardinali Daniel P., 2004, Current Drug Targets - Immune Endocrine and Metabolic Disorders, V4, P1, DOI 10.2174/1568008043340071
   Cardinali DP, 2010, CURR NEUROPHARMACOL, V8, P218, DOI 10.2174/157015910792246209
   Cardinali DR, 2011, NEUROENDOCRINOLOGY, V93, P133, DOI 10.1159/000324699
   CARDINALI DP, 1972, ENDOCRINOLOGY, V91, P1213, DOI 10.1210/endo-91-5-1213
   CARDINALI DP, 1980, EUR J PHARMACOL, V67, P151, DOI 10.1016/0014-2999(80)90025-4
   Carrillo-Vico A, 2004, FASEB J, V18, P537, DOI 10.1096/fj.03-0694fje
   Carrillo-Vico A, 2006, CURR OPIN INVEST DR, V7, P423
   Carroll JF, 2005, AM J HYPERTENS, V18, P1320, DOI 10.1016/j.amjhyper.2005.04.018
   Cavallo A, 2004, J PINEAL RES, V36, P262, DOI 10.1111/j.1600-079X.2004.00126.x
   Chahbouni M, 2010, J PINEAL RES, V48, P282, DOI 10.1111/j.1600-079X.2010.00752.x
   Chrousos GP, 2009, NAT REV ENDOCRINOL, V5, P374, DOI 10.1038/nrendo.2009.106
   Ciortea R, 2011, ANTICANCER RES, V31, P2637
   Claustrat B, 2005, SLEEP MED REV, V9, P11, DOI 10.1016/j.smrv.2004.08.001
   Conti A, 2000, J PINEAL RES, V28, P193, DOI 10.1034/j.1600-079X.2000.280401.x
   Coogan AN, 2008, BRAIN RES, V1232, P104, DOI 10.1016/j.brainres.2008.07.087
   Corbalán-Tutau MD, 2011, CHRONOBIOL INT, V28, P425, DOI 10.3109/07420528.2011.574766
   Corthay A, 2009, SCAND J IMMUNOL, V70, P326, DOI 10.1111/j.1365-3083.2009.02308.x
   Costantino G, 1998, EUR J PHARMACOL, V363, P57, DOI 10.1016/S0014-2999(98)00673-6
   Cutolo M, 2006, ANN NY ACAD SCI, V1069, P289, DOI 10.1196/annals.1351.027
   Cuzzocrea S, 1998, J PINEAL RES, V25, P78, DOI 10.1111/j.1600-079X.1998.tb00543.x
   Cuzzocrea S, 1999, J PINEAL RES, V27, P9, DOI 10.1111/j.1600-079X.1999.tb00591.x
   Cuzzocrea S, 1997, J PINEAL RES, V23, P106, DOI 10.1111/j.1600-079X.1997.tb00342.x
   DELZAR MDM, 1990, ACTA ENDOCRINOL-COP, V123, P453, DOI 10.1530/acta.0.1230453
   DeMuro RL, 2000, J CLIN PHARMACOL, V40, P781, DOI 10.1177/00912700022009422
   Deng WG, 2006, BLOOD, V108, P518, DOI 10.1182/blood-2005-09-3691
   Di WL, 1997, NEW ENGL J MED, V336, P1028, DOI 10.1056/NEJM199704033361418
   Dibner C, 2010, ANNU REV PHYSIOL, V72, P517, DOI 10.1146/annurev-physiol-021909-135821
   Dietrich K, 2011, DIABETIC MED
   Dijk Derk-Jan, 2009, J Clin Sleep Med, V5, pS6
   Dijk DJ, 1997, J PHYSIOL-LONDON, V505, P851, DOI 10.1111/j.1469-7793.1997.851ba.x
   Dijk DJ, 1999, ANN MED, V31, P130, DOI 10.3109/07853899908998789
   Dimitrov S, 2004, BRAIN BEHAV IMMUN, V18, P341, DOI 10.1016/j.bbi.2003.08.004
   DINGES DF, 1995, ADV NEUROIMMUNOL, V5, P97, DOI 10.1016/0960-5428(95)00002-J
   Domínguez-Rodríguez A, 2002, J PINEAL RES, V33, P248, DOI 10.1034/j.1600-079X.2002.02938.x
   Dubocovich ML, 2010, PHARMACOL REV, V62, P343, DOI 10.1124/pr.110.002832
   EDGAR DM, 1993, J NEUROSCI, V13, P1065
   Esquifino AI, 1999, BIOL SIGNAL RECEPT, V8, P178
   Facciolá G, 2001, EUR J CLIN PHARMACOL, V56, P881, DOI 10.1007/s002280000245
   Faraguna U, 2008, J NEUROSCI, V28, P4088, DOI 10.1523/JNEUROSCI.5510-07.2008
   Froy O, 2007, FRONT NEUROENDOCRIN, V28, P61, DOI 10.1016/j.yfrne.2007.03.001
   Galijasevic S, 2008, BIOCHEMISTRY-US, V47, P2668, DOI 10.1021/bi702016q
   Gangwisch JE, 2009, OBES REV, V10, P37, DOI 10.1111/j.1467-789X.2009.00663.x
   Gimble JM, 2009, OBES REV, V10, P1, DOI 10.1111/j.1467-789X.2009.00672.x
   Girotti L, 2000, J PINEAL RES, V29, P138, DOI 10.1034/j.1600-079X.2000.290302.x
   Gorgulu Y, 2009, BRAIN RES BULL, V80, P158, DOI 10.1016/j.brainresbull.2009.06.016
   Green CB, 2008, CELL, V134, P728, DOI 10.1016/j.cell.2008.08.022
   Grossman E, 2006, AM J MED, V119, P898, DOI 10.1016/j.amjmed.2006.02.002
   Hardeland R, 2011, PROG NEUROBIOL, V93, P350, DOI 10.1016/j.pneurobio.2010.12.004
   Hardeland R, 2009, J PINEAL RES, V47, P109, DOI 10.1111/j.1600-079X.2009.00701.x
   Hart CN, 2011, PEDIATR CLIN N AM, V58, P715, DOI 10.1016/j.pcl.2011.03.007
   Härtter S, 2001, CLIN PHARMACOL THER, V70, P10, DOI 10.1067/mcp.2001.116512
   Heiser P, 2000, EUR ARCH PSY CLIN N, V250, P16, DOI 10.1007/PL00007534
   Hobson JA, 2009, NAT REV NEUROSCI, V10, P803, DOI 10.1038/nrn2716
   Horne J, 2011, OBES REV, V12, pe84, DOI 10.1111/j.1467-789X.2010.00847.x
   Huang WY, 2011, J CLIN INVEST, V121, P2133, DOI 10.1172/JCI46043
   Huneault L, 2011, OBES REV, V12, pe64, DOI 10.1111/j.1467-789X.2010.00817.x
   Hussein MR, 2007, INT J EXP PATHOL, V88, P19, DOI 10.1111/j.1365-2613.2006.00512.x
   Iber C A-IS, 2007, Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications, V1st
   Irwin M, 2003, BRAIN BEHAV IMMUN, V17, P365, DOI 10.1016/S0889-1591(03)00031-X
   Irwin MR, 2010, BRAIN BEHAV IMMUN, V24, P54, DOI 10.1016/j.bbi.2009.06.001
   Ishihara Y, 2004, OBES RES, V12, P1067, DOI 10.1038/oby.2004.134
   Jiménez-Ortega V, 2009, REDOX REP, V14, P132, DOI 10.1179/135100009X392548
   Kanter M, 2006, ARCH TOXICOL, V80, P362, DOI 10.1007/s00204-005-0055-z
   Kato K, 2005, NEUROPHARMACOLOGY, V48, P301, DOI 10.1016/j.neuropharm.2004.09.007
   Kidd Parris, 2003, Altern Med Rev, V8, P223
   Kiefer T, 2002, BREAST CANCER RES TR, V71, P37, DOI 10.1023/A:1013301408464
   Kim JY, 2011, BMC MED GENET, V12, DOI 10.1186/1471-2350-12-82
   King H, 1998, DIABETES CARE, V21, P1414, DOI 10.2337/diacare.21.9.1414
   Knutson KL, 2006, ARCH INTERN MED, V166, P1768, DOI 10.1001/archinte.166.16.1768
   Koziróg M, 2011, J PINEAL RES, V50, P261, DOI 10.1111/j.1600-079X.2010.00835.x
   Krueger JM, 2008, CURR PHARM DESIGN, V14, P3408, DOI 10.2174/138161208786549281
   KRUEGER JM, 1984, J BIOL CHEM, V259, P2659
   Kubota T, 2000, AM J PHYSIOL-REG I, V279, pR786, DOI 10.1152/ajpregu.2000.279.3.R786
   Ladizesky MG, 2003, J PINEAL RES, V34, P143, DOI 10.1034/j.1600-079X.2003.00021.x
   Lam YY, 2011, OBESITY IN PRESS
   Lange T, 2011, BRAIN BEHAV IMMUN, V25, P14, DOI 10.1016/j.bbi.2010.08.008
   Lange T, 2010, ANN NY ACAD SCI, V1193, P48, DOI 10.1111/j.1749-6632.2009.05300.x
   Lavie P, 2001, ANNU REV PSYCHOL, V52, P277, DOI 10.1146/annurev.psych.52.1.277
   Lee KS, 2009, BMC MOL BIOL, V10, DOI 10.1186/1471-2199-10-45
   Leger D, 2004, AM J MED, V116, P91, DOI 10.1016/j.amjmed.2003.07.017
   Lewy A, 2006, CHRONOBIOL INT, V23, P403, DOI 10.1080/07420520500545862
   Logan RW, 2011, BRAIN BEHAV IMMUN, V25, P101, DOI 10.1016/j.bbi.2010.08.007
   Lumeng CN, 2011, J CLIN INVEST, V121, P2111, DOI 10.1172/JCI57132
   Lundmark PO, 2006, VISUAL NEUROSCI, V23, P853, DOI 10.1017/S0952523806230189
   Marpegan L, 2004, NEUROSCI LETT, V358, P9, DOI 10.1016/j.neulet.2003.12.112
   Marshall L, 2002, INT REV NEUROBIOL, V52, P93
   Mathes AM, 2008, CRIT CARE MED, V36, P2863, DOI 10.1097/CCM.0b013e318187b863
   Mayo JC, 2005, J NEUROIMMUNOL, V165, P139, DOI 10.1016/j.jneuroim.2005.05.002
   Mazepa RC, 1999, LIFE SCI, V66, P153
   McEwen BS, 2006, METABOLISM, V55, pS20, DOI 10.1016/j.metabol.2006.07.008
   Millan MJ, 2003, J PHARMACOL EXP THER, V306, P954, DOI 10.1124/jpet.103.051797
   Mills PJ, 2004, BRAIN BEHAV IMMUN, V18, P298, DOI 10.1016/j.bbi.2003.10.004
   Miyamoto M, 2009, CNS NEUROSCI THER, V15, P32, DOI 10.1111/j.1755-5949.2008.00066.x
   Mohan N, 1995, BIOCHEM MOL BIOL INT, V37, P1063
   Moldofsky H, 1999, SLEEP MED REV, V3, P325, DOI 10.1053/smrv.1999.0068
   Morin LP, 2006, BRAIN RES REV, V51, P1, DOI 10.1016/j.brainresrev.2005.08.003
   Moschen AR, 2011, MOL MED, V17, P840, DOI 10.2119/molmed.2010.00108
   Moschen AR, 2010, GUT, V59, P1259, DOI 10.1136/gut.2010.214577
   Motivala SJ, 2011, ANN BEHAV MED, V42, P141, DOI 10.1007/s12160-011-9280-2
   Mulchahey JJ, 2004, LIFE SCI, V75, P1843, DOI 10.1016/j.lfs.2004.03.023
   Naranjo MC, 2007, CELL MOL LIFE SCI, V64, P781, DOI 10.1007/s00018-007-6435-1
   Nduhirabandi F, 2011, J PINEAL RES, V50, P171, DOI 10.1111/j.1600-079X.2010.00826.x
   Neri B, 1998, ANTICANCER RES, V18, P1329
   Nishida S, 2003, J PINEAL RES, V35, P251, DOI 10.1034/j.1600-079X.2003.00083.x
   Nishida S, 2002, J PINEAL RES, V32, P26, DOI 10.1034/j.1600-079x.2002.10797.x
   Oishi K, 2004, BIOCHEM BIOPH RES CO, V317, P330, DOI 10.1016/j.bbrc.2004.03.055
   Okun ML, 2004, BRAIN BEHAV IMMUN, V18, P326, DOI 10.1016/j.bbi.2003.11.002
   Opp MR, 2009, IMMUNOL ALLERGY CLIN, V29, P295, DOI 10.1016/j.iac.2009.02.009
   Orzel-Gryglewska J, 2010, INT J OCCUP MED ENV, V23, P95, DOI 10.2478/v10001-010-0004-9
   Pace-Schott EF, 2002, NAT REV NEUROSCI, V3, P591, DOI 10.1038/nrn895
   Padilha HG, 2011, BRAZ J MED BIOL RES, V44, P992, DOI 10.1590/S0100-879X2011007500113
   Pala L, 2011, J NUTR META IN PRESS
   Pan M, 2006, J PINEAL RES, V41, P79, DOI 10.1111/j.1600-079X.2006.00346.x
   Pandi-Perumal SR, 2008, NAT CLIN PRACT NEURO, V4, P436, DOI 10.1038/ncpneuro0847
   Pandi-Perumal SR, 2008, PROG NEUROBIOL, V85, P335, DOI 10.1016/j.pneurobio.2008.04.001
   Pandi-Perumal SR, 2009, PROG NEUROBIOL, V88, P264, DOI 10.1016/j.pneurobio.2009.04.007
   PARDRIDGE WM, 1980, J NEUROCHEM, V34, P1761, DOI 10.1111/j.1471-4159.1980.tb11272.x
   Park HJ, 2007, J PINEAL RES, V43, P121, DOI 10.1111/j.1600-079X.2007.00452.x
   Parmeggiani PL, 2005, PHYSIOLOGIC NATURE OF SLEEP, P1
   Pattison DI, 2006, CURR MED CHEM, V13, P3271, DOI 10.2174/092986706778773095
   Peschke E, 2007, J PINEAL RES, V42, P350, DOI 10.1111/j.1600-079X.2007.00426.x
   Petrovsky N, 1998, Int Rev Immunol, V16, P635, DOI 10.3109/08830189809043012
   POZO D, 1994, LIFE SCI, V55, pPL455, DOI 10.1016/0024-3205(94)00532-X
   Prokopenko I, 2009, NAT GENET, V41, P77, DOI 10.1038/ng.290
   Prunet-Marcassus B, 2003, ENDOCRINOLOGY, V144, P5347, DOI 10.1210/en.2003-0693
   Puchalski SS, 2003, ENDOCRINE, V21, P163, DOI 10.1385/ENDO:21:2:163
   RAIKHLIN NT, 1976, ACTA HISTOCHEM, V55, P19, DOI 10.1016/S0065-1281(76)80092-X
   Rajaratnam SMW, 2009, LANCET, V373, P482, DOI 10.1016/S0140-6736(08)61812-7
   Raskind MA, 2007, NEUROPSYCHOPHARMACOL, V32, P284, DOI 10.1038/sj.npp.1301093
   Rector DM, 2009, EUR J NEUROSCI, V29, P1771, DOI 10.1111/j.1460-9568.2009.06717.x
   Reddy AB, 2005, MUTAT RES-FUND MOL M, V574, P76, DOI 10.1016/j.mrfmmm.2005.01.024
   Redwine L, 2000, J CLIN ENDOCR METAB, V85, P3597, DOI 10.1210/jc.85.10.3597
   Reiter R.J., 2011, Ann Med
   Reiter RJ, 2009, CRIT REV BIOCHEM MOL, V44, P175, DOI 10.1080/10409230903044914
   Ríos-Lugo MJ, 2010, J PINEAL RES, V49, P342, DOI 10.1111/j.1600-079X.2010.00798.x
   SACK RL, 1992, J CLIN ENDOCR METAB, V75, P127, DOI 10.1210/jcem.75.1.1619000
   Sainz RM, 2003, CELL MOL LIFE SCI, V60, P1407, DOI 10.1007/s00018-003-2319-1
   Sakotnik A, 1999, EUR HEART J, V20, P1314, DOI 10.1053/euhj.1999.1527
   Sanchez-Mateos S, 2007, MATURITAS, V58, P91, DOI 10.1016/j.maturitas.2007.06.006
   Saper CB, 2005, NATURE, V437, P1257, DOI 10.1038/nature04284
   Sartori C, 2009, ENDOCRINOLOGY, V150, P5311, DOI 10.1210/en.2009-0425
   Savard J, 2003, PSYCHOSOM MED, V65, P211, DOI 10.1097/01.PSY.0000033126.22740.F3
   Scheer FAJL, 2004, HYPERTENSION, V43, P192, DOI 10.1161/01.HYP.0000113293.15186.3b
   Scheer FAJL, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000721
   Scheer FAJL, 2009, P NATL ACAD SCI USA, V106, P4453, DOI 10.1073/pnas.0808180106
   Selgas L, 1998, BIOL SIGNAL RECEPT, V7, P15
   Sharma S, 2010, INT J ENDOCRINOL, V2010, DOI 10.1155/2010/270832
   She MH, 2009, PHARMACOL RES, V59, P248, DOI 10.1016/j.phrs.2009.01.005
   Shieh JM, 2009, J PINEAL RES, V47, P339, DOI 10.1111/j.1600-079X.2009.00720.x
   Slominski A, 2005, ENDOCRINE, V27, P137, DOI 10.1385/ENDO:27:2:137
   Srinivasan V, 2010, J CRIT CARE, V25
   Srinivasan Venkatramanujam, 2010, Int J Alzheimers Dis, V2011, P741974, DOI 10.4061/2011/741974
   Srinivasan Venkatramanujam, 2011, Int J Alzheimers Dis, V2011, P326320, DOI 10.4061/2011/326320
   Srinivasan Venkatramanujam, 2011, Ther Adv Neurol Disord, V4, P297, DOI 10.1177/1756285611406166
   Stöger R, 2008, BIOESSAYS, V30, P156, DOI 10.1002/bies.20700
   Stumpf I, 2009, J PINEAL RES, V46, P140, DOI 10.1111/j.1600-079X.2008.00638.x
   Szelényi J, 2001, BRAIN RES BULL, V54, P329, DOI 10.1016/S0361-9230(01)00428-2
   Takeda N, 2010, ADV DRUG DELIVER REV, V62, P956, DOI 10.1016/j.addr.2010.04.011
   Tan DX, 2011, OBES REV, V12, P167, DOI 10.1111/j.1467-789X.2010.00756.x
   Tan DX, 2007, J PINEAL RES, V42, P28, DOI 10.1111/j.1600-079X.2006.00407.x
   Tan DX, 2003, J PINEAL RES, V34, P75, DOI 10.1034/j.1600-079X.2003.02111.x
   Tan DX, 1999, BBA-GEN SUBJECTS, V1472, P206, DOI 10.1016/S0304-4165(99)00125-7
   Tilg H, 2011, J CLIN INVEST, V121, P2126, DOI 10.1172/JCI58109
   Toth LA, 2001, AM J PHYSIOL-REG I, V280, pR1806, DOI 10.1152/ajpregu.2001.280.6.R1806
   Tsujimura T, 2009, DIABETES RES CLIN PR, V85, P286, DOI 10.1016/j.diabres.2009.07.001
   Turek FW, 2004, SLEEP MED, V5, P523, DOI 10.1016/j.sleep.2004.07.009
   Tutuncu NB, 2005, J PINEAL RES, V39, P43, DOI 10.1111/j.1600-079X.2005.00213.x
   VACAS MI, 1991, J PINEAL RES, V11, P135, DOI 10.1111/j.1600-079X.1991.tb00468.x
   Vachharajani NN, 2003, J PHARM SCI, V92, P760, DOI 10.1002/jps.10348
   Van Cauter E, 2008, SLEEP MED, V9, pS23, DOI 10.1016/S1389-9457(08)70013-3
   van Mark A, 2010, J OCCUP MED TOXICOL, V5, DOI 10.1186/1745-6673-5-18
   Vane JR, 1998, INFLAMM RES, V47, pS77
   Vgontzas AN, 2004, J CLIN ENDOCR METAB, V89, P2119, DOI 10.1210/jc.2003-031562
   Vgontzas AN, 2005, NEUROIMMUNOMODULAT, V12, P131, DOI 10.1159/000084844
   Vincent HK, 2007, DIABETES OBES METAB, V9, P813, DOI 10.1111/j.1463-1326.2007.00692.x
   VOORDOUW BCG, 1992, J CLIN ENDOCR METAB, V74, P108, DOI 10.1210/jc.74.1.108
   WALDHAUSER F, 1984, NEUROENDOCRINOLOGY, V39, P307, DOI 10.1159/000123997
   Wang MF, 2009, PEDIATR NEONATOL, V50, P222, DOI 10.1016/S1875-9572(09)60067-X
   Weishaupt JH, 2006, J PINEAL RES, V41, P313, DOI 10.1111/j.1600-079X.2006.00377.x
   Wilson SJ, 2010, J PSYCHOPHARMACOL, V24, P1577, DOI 10.1177/0269881110379307
   Wirtz PH, 2008, J PINEAL RES, V44, P358, DOI 10.1111/j.1600-079X.2007.00535.x
   Wirtz PH, 2008, J PINEAL RES, V44, P127, DOI 10.1111/j.1600-079X.2007.00499.x
   Wu YW, 2009, ANN NEUROL, V66, P663, DOI 10.1002/ana.21766
   Yanagihara H, 2006, CHRONOBIOL INT, V23, P905, DOI 10.1080/07420520600827103
   Yaprak M, 2003, INT J CARDIOL, V89, P103, DOI 10.1016/S0167-5273(02)00461-8
   Ye JP, 2011, CLIN EXP PHARMACOL P, V38, P872, DOI 10.1111/j.1440-1681.2011.05596.x
   Yehuda S, 2009, J INTERF CYTOK RES, V29, P393, DOI 10.1089/jir.2008.0080
   Young ME, 2006, AM J PHYSIOL-HEART C, V290, pH1, DOI 10.1152/ajpheart.00582.2005
   Zhdanova IV, 2001, J CLIN ENDOCR METAB, V86, P4727, DOI 10.1210/jc.86.10.4727
   Ziebell JM, 2010, NEUROTHERAPEUTICS, V7, P22, DOI 10.1016/j.nurt.2009.10.016
   Zielinski Mark R, 2011, Front Biosci (Schol Ed), V3, P632, DOI 10.2741/s176
NR 216
TC 23
Z9 25
U1 2
U2 10
PU MAGHIRA & MAAS PUBLICATIONS
PI MUNSBACH
PA MAGHIRA & MAAS S A R L, 6C, RUE GABRIEL LIPPMANN, L-5365 MUNSBACH,
   LUXEMBOURG
SN 0172-780X
EI 2354-4716
J9 NEUROENDOCRINOL LETT
JI Neuroendocrinol. Lett.
PY 2011
VL 32
IS 5
BP 588
EP 606
PG 19
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 896CV
UT WOS:000300543900003
PM 22167135
DA 2025-06-11
ER

PT J
AU Razny, U
   Wator, L
   Polus, A
   Kiec-Wilk, B
   Wan, YJY
   Dyduch, G
   Tomaszewska, R
   Dembinska-Kiec, A
AF Razny, Urszula
   Wator, Lukasz
   Polus, Anna
   Kiec-Wilk, Beata
   Wan, Yu-Jui Yvonne
   Dyduch, Grzegorz
   Tomaszewska, Romana
   Dembinska-Kiec, Aldona
TI Modulatory effect of high saturated fat diet-induced metabolic
   disturbances on angiogenic response in hepatocyte RXRα knockout mice
SO PHARMACOLOGICAL REPORTS
LA English
DT Article
DE angiogenesis; adipogenesis; apoptosis; metabolic syndrome; microarray;
   RXR alpha ko
ID X-RECEPTOR-ALPHA; GROWTH-FACTOR VEGF; PROTEIN-KINASE-C;
   ENDOTHELIAL-CELLS; ARACHIDONIC-ACID; OXIDATIVE STRESS; DEFICIENT MICE;
   ADIPOGENESIS; ACTIVATION; OBESITY
AB Metabolic syndrome and diabetes lead to pathological angiogenesis and angiopathy. Metabolic disturbances occur as an effect of genetic and environmental interaction. Hyperleptinemia accompanies obesity and leptin is a potent proangiogenic factor. The aim of the study was to investigate the effect of high fat diet-induced alterations in gene expression and angiogenic response in the hRXR alpha ko mice lacking of hyperglycemia.
   hRXR alpha ko and control mice were fed either standard or high saturated fat (HF) diet for 7 weeks. Body weight and biochemical parameters (glucose, triglycerides, cholesterol), insulin and adipokines (leptin, adiponectin) were monitored. At sixth week of feeding, mice were subcutaneously injected for 6 days with matrigel containing bFGF. Then, matrigel plugs were used for immunohistochemical staining of cells with CD31 antibody and gene expression assessment (by microarray confirmed for some genes with quantitative real time PCR). For description of angiogenesis CD31 positive structures were counted in the matrigel sections. HF diet feeding of the hRXRa ko mice resulted in increased serum cholesterol and leptin level and in tendency to decrease angiogenesis (number of vessels with lumen). The microarray studies revealed that HF diet down-regulated genes related to angiogenesis (Nos3, Kdr) and up-regulated genes connected with apoptosis (activators of caspase 3, proapoptotic genes Bcl2) and proinflammatory pathway (Nf kappa B pathway, Tnf alpha).
   Summing up, HF diet feeding of hRXR alpha ko mice resulted in dyslipidemia and hyperleptinemia as well as impaired angiogenic response, and cell apoptosis. These results argue for independent participation of dyslipidemia and hyperleptinemia in pathology of angiogenic response associating metabolic syndrome.
C1 [Razny, Urszula; Wator, Lukasz; Polus, Anna; Kiec-Wilk, Beata; Dembinska-Kiec, Aldona] Jagiellonian Univ, Coll Med, Dept Clin Biochem, PL-31501 Krakow, Poland.
   [Dyduch, Grzegorz; Tomaszewska, Romana] Jagiellonian Univ, Coll Med, Dept Pathomorphol, PL-31501 Krakow, Poland.
   [Wan, Yu-Jui Yvonne] Univ Kansas, Med Ctr, Dept Pharmacol Toxicol & Therapeut, Kansas City, KS 66160 USA.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   University of Kansas; University of Kansas Medical Center
RP Razny, U (corresponding author), Jagiellonian Univ, Coll Med, Dept Clin Biochem, Kopernika 15A, PL-31501 Krakow, Poland.
EM urazny@cm-uj.krakow.pl
RI Razny, Urszula/U-2550-2019
FU Polish Committee of Science [PBZ-MIN-005/P04/2002/5]; National
   Institutes of Health [CA53596, AA14147, COBRE P20 RR021940]; Molecular
   Biology Core under COBRE as well as the Liver Center at KUMC
FX We would like to thank Dr. Anna Knapp for kind help in preparation of
   this paper. Supported by Polish Committee of Science Grant No.
   PBZ-MIN-005/P04/2002/5, National Institutes of Health grants CA53596,
   AA14147, and COBRE P20 RR021940, the Molecular Biology Core under COBRE
   as well as the Liver Center at KUMC.
CR Ahmad S, 2006, CIRC RES, V99, P715, DOI 10.1161/01.RES.0000243989.46006.b9
   Ambati S, 2007, BIOCHEM PHARMACOL, V73, P378, DOI 10.1016/j.bcp.2006.10.009
   Chinen I, 2007, ENDOCRINOLOGY, V148, P160, DOI 10.1210/en.2006-1132
   Clarke SD, 1999, AM J CLIN NUTR, V70, P566
   Dembinska-Kiec A, 1997, ADV EXP MED BIOL, V433, P163
   Fève B, 2005, BEST PRACT RES CL EN, V19, P483, DOI 10.1016/j.beem.2005.07.007
   Gupta K, 2005, POSTGRAD MED J, V81, P236, DOI 10.1136/pgmj.2004.023309
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Inoguchi T, 2000, DIABETES, V49, P1939, DOI 10.2337/diabetes.49.11.1939
   Kawasaki S, 2006, INTERNAL MED, V45, P1267, DOI 10.2169/internalmedicine.45.1620
   Kiec-Wilk B, 2005, J PHYSIOL PHARMACOL, V56, P149
   Kim KY, 2006, J BIOL CHEM, V281, P13503, DOI 10.1074/jbc.M510357200
   Kraml P, 2004, PHYSIOL RES, V53, P471, DOI 10.33549/physiolres.930533
   LEE TS, 1989, P NATL ACAD SCI USA, V86, P5141, DOI 10.1073/pnas.86.13.5141
   Massiera F, 2003, J LIPID RES, V44, P271, DOI 10.1194/jlr.M200346-JLR200
   Matsumoto T, 2006, J ATHEROSCLER THROMB, V13, P130, DOI 10.5551/jat.13.130
   McLaughlin T, 2003, ANN INTERN MED, V139, P802, DOI 10.7326/0003-4819-139-10-200311180-00007
   Nishimura S, 2007, DIABETES, V56, P1517, DOI 10.2337/db06-1749
   Oliveros LB, 2004, BRAZ J MED BIOL RES, V37, P311, DOI 10.1590/S0100-879X2004000300004
   Papetti M, 2002, AM J PHYSIOL-CELL PH, V282, pC947, DOI 10.1152/ajpcell.00389.2001
   Park HY, 2001, EXP MOL MED, V33, P95, DOI 10.1038/emm.2001.17
   Parvanova A, 2004, J CLIN ENDOCR METAB, V89, P4371, DOI 10.1210/jc.2003-032076
   Polverini Peter J, 2002, J Dent Educ, V66, P962
   Scarfo LM, 2001, AM J PHYSIOL-HEART C, V280, pH294, DOI 10.1152/ajpheart.2001.280.1.H294
   Stitt AW, 2005, PHARMACOL REP, V57, P156
   Sun XM, 2002, J BIOL CHEM, V277, P11345, DOI 10.1074/jbc.M109893200
   Tei K, 2002, CANCER RES, V62, P6289
   Vidal-Puig A, 1999, OBES RES, V7, P133, DOI 10.1002/j.1550-8528.1999.tb00694.x
   Villarroya F, 2004, CURR MED CHEM, V11, P795, DOI 10.2174/0929867043455747
   Vucenik I, 2004, CARCINOGENESIS, V25, P2115, DOI 10.1093/carcin/bgh232
   Wan YJY, 2000, J BIOL CHEM, V275, P28285
   Wan YJY, 2000, MOL CELL BIOL, V20, P4436, DOI 10.1128/MCB.20.12.4436-4444.2000
   Wan YJY, 2003, ENDOCRINOLOGY, V144, P605, DOI 10.1210/en.2002-221003
   West CML, 2001, CANCER RES, V61, P2907
   ZENG G, 2000, CANCER RES, V23, P6670
NR 35
TC 4
Z9 4
U1 0
U2 2
PU POLISH ACAD SCIENCES INST PHARMACOLOGY
PI KRAKOW
PA SMETNA 12, 31-343 KRAKOW, POLAND
SN 1734-1140
J9 PHARMACOL REP
JI Pharmacol. Rep.
PD NOV-DEC
PY 2010
VL 62
IS 6
BP 1078
EP 1089
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 727VB
UT WOS:000287829800012
PM 21273665
DA 2025-06-11
ER

PT J
AU Xu, XB
   Jhun, BS
   Ha, CH
   Jin, ZG
AF Xu, Xiangbin
   Jhun, Bong Sook
   Ha, Chang Hoon
   Jin, Zheng-Gen
TI Molecular mechanisms of ghrelin-mediated endothelial nitric oxide
   synthase activation
SO ENDOCRINOLOGY
LA English
DT Article
ID PROTEIN-KINASE-B; PLASMA GHRELIN; SHEAR-STRESS; NO SYNTHASE; CIRCULATING
   GHRELIN; INSULIN-RESISTANCE; HEART-FAILURE; HUMAN OBESITY; IN-VIVO; AMP
AB Metabolic syndrome accelerates the atherosclerotic process, and the earliest event of which is endothelial dysfunction. Ghrelin, a newly discovered gastric peptide, improves endothelial function and inhibits proatherogenic changes. In particular, low ghrelin concentration has been associated with several features of metabolic syndrome, including obesity, insulin resistance, and high blood pressure. However, the molecular mechanisms underlying ghrelin vascular actions remain largely unclear. Here, we showed that ghrelin activated endothelial nitric oxide (NO) synthase (eNOS) in cultured endothelial cells (ECs) and in intact vessels. Specifically, ghrelin rapidly induced phosphorylation of eNOS on an activation site and production of NO in human umbilical vein ECs and bovine aortic ECs. The eNOS phosphorylation was also observed in mouse aortas ex vivo perfused with ghrelin and in aortic tissues isolated from mice injected with ghrelin. Mechanistically, ghrelin stimulated AMP-activated protein kinase (AMPK) and Akt activation in cultured ECs and intact vessels. Inhibiting AMPK and Akt with their pharmacological inhibitors, small interference RNA and adenoviruses carried dominant-negative mutants, markedly attenuated ghrelin-induced eNOS activation, and NO production. Furthermore, ghrelin receptor/Gq protein/ calcium-dependent pathway mediates activation of AMPK, Akt, and eNOS, and calmodulin-dependent kinase kinase is a potential convergent point to regulate Akt and AMPK activation in ghrelin signaling. Importantly, eNOS activation is critical for ghrelin inhibition of vascular inflammation. Together, both in vitro and in vivo data demonstrate a new role of ghrelin signaling for eNOS activation, and highlight the therapeutic potential for ghrelin to correct endothelial dysfunction associated with atherosclerotic vascular diseases and metabolic syndrome.
C1 [Jin, Zheng-Gen] Univ Rochester, Med Ctr, Aab Cardiovasc Res Inst, Dept Med, Rochester, NY 14642 USA.
C3 University of Rochester
RP Jin, ZG (corresponding author), Univ Rochester, Med Ctr, Aab Cardiovasc Res Inst, Dept Med, 601 Elmwood Ave, Rochester, NY 14642 USA.
EM zheng-gen_jin@urmc.rochester.edu
RI Ha, C/GZL-9046-2022; zhang, wenjing/AAE-7146-2019
OI Jhun, Bong Sook/0000-0001-9916-9962
FU NHLBI NIH HHS [R01 HL080611, R01 HL-080611] Funding Source: Medline
CR Aljada A, 2000, METABOLISM, V49, P147, DOI 10.1016/S0026-0495(00)91039-4
   Birnbaum MJ, 2005, MOL CELL, V19, P289, DOI 10.1016/j.molcel.2005.07.012
   Calvert JW, 2008, DIABETES, V57, P696, DOI 10.2337/db07-1098
   Chen H, 2003, J BIOL CHEM, V278, P45021, DOI 10.1074/jbc.M307878200
   Chen ZP, 1999, FEBS LETT, V443, P285, DOI 10.1016/S0014-5793(98)01705-0
   Davis BJ, 2006, DIABETES, V55, P496, DOI 10.2337/diabetes.55.02.06.db05-1064
   Dimmeler S, 1999, NATURE, V399, P601, DOI 10.1038/21224
   Drew BG, 2004, P NATL ACAD SCI USA, V101, P6999, DOI 10.1073/pnas.0306266101
   Dudzinski DM, 2006, ANNU REV PHARMACOL, V46, P235, DOI 10.1146/annurev.pharmtox.44.101802.121844
   Eckel RH, 2002, CIRCULATION, V105, P2923, DOI 10.1161/01.CIR.0000017823.53114.4C
   Fagerberg B, 2003, METABOLISM, V52, P1460, DOI 10.1016/S0026-0495(03)00274-9
   Fulton D, 1999, NATURE, V399, P597, DOI 10.1038/21218
   Harrison DG, 1997, J CLIN INVEST, V100, P2153, DOI 10.1172/JCI119751
   Iantorno M, 2007, AM J PHYSIOL-ENDOC M, V292, pE756, DOI 10.1152/ajpendo.00570.2006
   Jin ZG, 2006, ARTERIOSCL THROM VAS, V26, P959, DOI 10.1161/01.ATV.0000217612.29550.8b
   Jin ZG, 2005, J BIOL CHEM, V280, P12305, DOI 10.1074/jbc.M500294200
   Jin ZG, 2003, CIRC RES, V93, P354, DOI 10.1161/01.RES.0000089257.94002.96
   Kemp BE, 2003, BIOCHEM SOC T, V31, P162
   Kojima M, 1999, NATURE, V402, P656, DOI 10.1038/45230
   Landmesser U, 2004, CIRCULATION, V109, P27, DOI 10.1161/01.CIR.0000129501.88485.1f
   Li WG, 2004, CIRCULATION, V109, P2221, DOI 10.1161/01.CIR.0000127956.43874.F2
   Libby P, 2005, CIRCULATION, V111, P3489, DOI 10.1161/CIRCULATIONAHA.104.529651
   Locatelli V, 1999, ENDOCRINOLOGY, V140, P4024, DOI 10.1210/en.140.9.4024
   Looft-Wilson R, 2007, J CLIN INVEST, V117, P1961, DOI 10.1172/JCI29877
   Lungu AO, 2004, J BIOL CHEM, V279, P48794, DOI 10.1074/jbc.M313897200
   Luo ZY, 2000, J CLIN INVEST, V106, P493, DOI 10.1172/JCI9419
   Nagaya N, 2004, CIRCULATION, V110, P3674, DOI 10.1161/01.CIR.0000149746.62908.BB
   Nakazato M, 2001, NATURE, V409, P194, DOI 10.1038/35051587
   Nofer JR, 2004, J CLIN INVEST, V113, P569, DOI 10.1172/JCI200418004
   Ouchi N, 2004, J BIOL CHEM, V279, P1304, DOI 10.1074/jbc.M310389200
   Pang JJ, 2004, AM J PHYSIOL-HEART C, V286, pH1063, DOI 10.1152/ajpheart.00648.2003
   Pöykkö SM, 2003, DIABETES, V52, P2546, DOI 10.2337/diabetes.52.10.2546
   Sessa WC, 2005, MEM I OSWALDO CRUZ, V100, P15, DOI 10.1590/S0074-02762005000900004
   Shiiya T, 2002, J CLIN ENDOCR METAB, V87, P240, DOI 10.1210/jc.87.1.240
   Shimizu Y, 2003, BIOCHEM BIOPH RES CO, V310, P830, DOI 10.1016/j.bbrc.2003.09.085
   Shinde UA, 2005, J HYPERTENS, V23, P779, DOI 10.1097/01.hjh.0000163146.20330.bc
   Tesauro M, 2005, CIRCULATION, V112, P2986, DOI 10.1161/CIRCULATIONAHA.105.553883
   Tschöp M, 2001, DIABETES, V50, P707, DOI 10.2337/diabetes.50.4.707
   Tschöp M, 2000, NATURE, V407, P908, DOI 10.1038/35038090
   Wong C, 2005, J BIOL CHEM, V280, P33262, DOI 10.1074/jbc.M503198200
   Xu XB, 2005, AM J PHYSIOL-HEART C, V289, pH1643, DOI 10.1152/ajpheart.01042.2004
   Xu XB, 2003, ENDOCRINOLOGY, V144, P5050, DOI 10.1210/en.2003-0025
   Yano S, 1998, NATURE, V396, P584, DOI 10.1038/25147
   Yildiz BO, 2004, P NATL ACAD SCI USA, V101, P10434, DOI 10.1073/pnas.0403465101
   Yin W, 2003, J BIOL CHEM, V278, P43074, DOI 10.1074/jbc.M308484200
   Zeiher AM, 1996, LANCET, V348, pS10, DOI 10.1016/S0140-6736(96)98004-6
   Zhang YJ, 2006, ARTERIOSCL THROM VAS, V26, P1281, DOI 10.1161/01.ATV.0000221230.08596.98
   Zieman SJ, 2001, CIRC RES, V88, P97, DOI 10.1161/01.RES.88.1.97
   Zou MH, 2002, J BIOL CHEM, V277, P32552, DOI 10.1074/jbc.M204512200
NR 49
TC 90
Z9 98
U1 0
U2 5
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD AUG
PY 2008
VL 149
IS 8
BP 4183
EP 4192
DI 10.1210/en.2008-0255
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 329AV
UT WOS:000257840200047
PM 18450953
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Karbowska, Z
   Cierpiszewska, K
   Maruszczak, K
   Sukhachova, I
   Szwankowska, D
   Piotrowski, I
AF Karbowska, Zuzanna
   Cierpiszewska, Katarzyna
   Maruszczak, Klara
   Sukhachova, Ivanna
   Szwankowska, Dominika
   Piotrowski, Igor
TI Impact of testosterone levels and testosterone replacement therapy on
   men's health
SO JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE testosterone; testosterone de ficiency; functional hypogonadism;
   late-onset hypogonadism (LOH); testosterone replacement therapy (TRT)
ID HORMONE-BINDING GLOBULIN; METABOLIC SYNDROME; CARDIOVASCULAR EVENTS;
   DEFICIENCY SYNDROME; PROSTATE-CANCER; SEX-DIFFERENCES; RISK; MORTALITY;
   SPERMATOGENESIS; ERYTHROCYTOSIS
AB Various studies have shown that testosterone levels have a heavy impact on areas of a man's health. Low serum testosterone (and, by analogy, late -onset hypogonadism) may be responsible for such conditions as type 2 diabetes, obesity in the abdominal area, and, most of all, heightened cardiovascular risk (CV). Among other outcomes, researchers have pointed out metabolic syndrome and dyslipidemia, as well as an increased risk of anxiety disorders and major depressive disorders. There have also been reports of testosterone's influence on fertility, bone mineral density, and the development of polycythemia. Low testosterone can have a variety of effects, all of which increase the risk of premature death by raising inflammatory marker levels. Overly high testosterone, however, has been proven to have a notable influence on men's personalities, as well as other psychological and social traits, both in endogenously elevated testosterone levels and in patients with a history of anabolic-androgenic steroid use. The last decade's research on testosterone's impact on the organism has yielded contradictory results. Therefore, examination and understanding of the influence of its abnormal levels prove essential to not only guarantee the best quality of hypogonadism treatment but also to ef ficiently prevent any side effects or complications associated with testosterone use.
C1 [Karbowska, Zuzanna; Cierpiszewska, Katarzyna; Maruszczak, Klara; Sukhachova, Ivanna; Szwankowska, Dominika] Poznan Univ Med Sci, Fac Med, Poznan, Poland.
   [Piotrowski, Igor] Greater Poland Canc Ctr, Radiobiol Labs, Dept Med Phys, Poznan, Poland.
C3 Poznan University of Medical Sciences; Wielkopolskie Centrum Onkologii
RP Karbowska, Z (corresponding author), Poznan Univ Med Sci, Fac Med, Poznan, Poland.
EM zuzanna.karbowska99@gmail.com
RI Cierpiszewska, Katarzyna/MIP-1004-2025
OI Piotrowski, Igor/0000-0002-4985-9321
CR Aromäki AS, 2002, PSYCHIAT RES, V110, P239, DOI 10.1016/S0165-1781(02)00109-9
   Ayele HT, 2021, THROMB RES, V199, P123, DOI 10.1016/j.thromres.2020.12.029
   Bachman E, 2014, J GERONTOL A-BIOL, V69, P725, DOI 10.1093/gerona/glt154
   Bandeira L, 2022, ARCH ENDOCRIN METAB, V66, P739
   Basaria S, 2010, NEW ENGL J MED, V363, P109, DOI 10.1056/NEJMoa1000485
   Bassil Nazem, 2009, Ther Clin Risk Manag, V5, P427
   Bauman WA, 2011, HORM METAB RES, V43, P574, DOI 10.1055/s-0031-1280797
   Beauchet O, 2006, EUR J ENDOCRINOL, V155, P773, DOI 10.1530/eje.1.02306
   Bianchi VE, 2019, J ENDOCR SOC, V3, P91, DOI 10.1210/js.2018-00186
   Blaya R, 2016, AGING MALE, V19, P85, DOI 10.3109/13685538.2016.1154523
   Boden WE, 2020, AM HEART J, V224, P65, DOI 10.1016/j.ahj.2020.03.016
   Boyanov M A, 2003, Aging Male, V6, P1
   Cannarella R, 2022, MINERVA UROL NEPHROL, V74, P418, DOI 10.23736/S2724-6051.21.04307-X
   Çatakoglu AB, 2017, TURK KARDIYOL DERN A, V45, P664, DOI 10.5543/tkda.2017.00531
   Christou MA, 2017, SPORTS MED, V47, P1869, DOI 10.1007/s40279-017-0709-z
   Claps M, 2018, CLIN GENITOURIN CANC, V16, P165, DOI 10.1016/j.clgc.2018.01.005
   Coccaro EF, 2007, J PSYCHIATR RES, V41, P488, DOI 10.1016/j.jpsychires.2006.04.009
   Corona G, 2020, ANDROLOGY-US, V8, P970, DOI 10.1111/andr.12770
   Corona G, 2018, J SEX MED, V15, P1260, DOI 10.1016/j.jsxm.2018.06.012
   Corona G, 2018, J SEX MED, V15, P820, DOI 10.1016/j.jsxm.2018.04.641
   Corona G, 2013, ARCH ESP UROL, V66, P711
   DABBS JM, 1987, PSYCHOSOM MED, V49, P174, DOI 10.1097/00006842-198703000-00007
   DABBS JM, 1995, PERS INDIV DIFFER, V18, P627, DOI 10.1016/0191-8869(94)00177-T
   Ding EL, 2006, JAMA-J AM MED ASSOC, V295, P1288, DOI 10.1001/jama.295.11.1288
   Dreher JC, 2016, P NATL ACAD SCI USA, V113, P11633, DOI 10.1073/pnas.1608085113
   Fallara G, 2022, J SEX MED, V19, P1243, DOI 10.1016/j.jsxm.2022.05.145
   Fantus RJ, 2021, EUR UROL OPEN SCI, V29, P89, DOI 10.1016/j.euros.2021.05.008
   Finkle WD, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0085805
   Golds G, 2017, INT J ENDOCRINOL, V2017, DOI 10.1155/2017/4602129
   Gouda SI, 2022, ARCH ITAL UROL ANDRO, V94, P464, DOI 10.4081/aiua.2022.4.464
   Grinspoon S, 1998, ANN INTERN MED, V129, P18, DOI 10.7326/0003-4819-129-1-199807010-00005
   Haider MZ, 2023, StatPearls
   Harman SM, 2001, J CLIN ENDOCR METAB, V86, P724, DOI 10.1210/jc.86.2.724
   Hauger LE, 2021, DRUG ALCOHOL DEPEN, V221, DOI 10.1016/j.drugalcdep.2021.108604
   Hautanen A, 2000, INT J OBESITY, V24, pS64, DOI 10.1038/sj.ijo.0801281
   HOCKING WG, 1989, BLOOD REV, V3, P59, DOI 10.1016/0268-960X(89)90026-X
   House SJ, 2017, J FORENSIC SCI, V62, P1360, DOI 10.1111/1556-4029.13469
   Hudson J, 2022, LANCET HEALTH LONGEV, V3, pE381, DOI 10.1016/S2666-7568(22)00096-4
   Ide V, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22010021
   Kaipainen A, 2019, PROSTATE, V79, P1530, DOI 10.1002/pros.23874
   Khosla S, 2018, CSH PERSPECT MED, V8, DOI 10.1101/cshperspect.a031211
   Kumari N, 2021, CUREUS J MED SCIENCE, V13, DOI 10.7759/cureus.16288
   Laaksonen DE, 2004, DIABETES CARE, V27, P1036, DOI 10.2337/diacare.27.5.1036
   LeBlanc ES, 2011, J CLIN ENDOCR METAB, V96, P3855, DOI 10.1210/jc.2011-0312
   Lester JF, 2015, DRUG HEALTHC PATIENT, V7, P129, DOI 10.2147/DHPS.S50549
   Leutner M, 2022, WIEN KLIN WOCHENSCHR, V134, P1, DOI 10.1007/s00508-021-01903-1
   Levcikova M, 2017, BRATISL MED J, V118, P654, DOI 10.4149/BLL_2017_124
   Li D, 2022, CELL HOST MICROBE, V30, P329, DOI 10.1016/j.chom.2022.01.001
   Lincoff AM, 2023, NEW ENGL J MED, V389, P107, DOI 10.1056/NEJMoa2215025
   Mangolim AS, 2022, EUR J ENDOCRINOL, V186, P123, DOI 10.1530/EJE-21-0473
   Maresch CC, 2018, HUM REPROD UPDATE, V24, P86, DOI 10.1093/humupd/dmx033
   Marriott RJ, 2021, BMJ OPEN, V11, DOI 10.1136/bmjopen-2020-048013
   McHenry J, 2014, FRONT NEUROENDOCRIN, V35, P42, DOI 10.1016/j.yfrne.2013.09.001
   MOORADIAN AD, 1987, ENDOCR REV, V8, P1, DOI 10.1210/edrv-8-1-1
   Morales A, 2008, CUAJ-CAN UROL ASSOC, V2, P52
   Muraleedharan V, 2013, EUR J ENDOCRINOL, V169, P725, DOI 10.1530/EJE-13-0321
   Navarro G, 2016, CELL METAB, V23, P837, DOI 10.1016/j.cmet.2016.03.015
   Piacentino D, 2015, CURR NEUROPHARMACOL, V13, P101, DOI 10.2174/1570159X13666141210222725
   Pinyerd Belinda, 2005, J Pediatr Nurs, V20, P75, DOI 10.1016/j.pedn.2004.12.011
   Randi ML, 2016, ANN HEMATOL, V95, P233, DOI 10.1007/s00277-015-2548-z
   Rastrelli G, 2014, ANDROLOGY-US, V2, P794, DOI 10.1111/andr.262
   Rodriguez A, 2007, J CLIN ENDOCR METAB, V92, P3568, DOI 10.1210/jc.2006-2764
   Saeedi P, 2019, DIABETES RES CLIN PR, V157, DOI 10.1016/j.diabres.2019.107843
   Salter CA, 2019, BJU INT, V124, P722, DOI 10.1111/bju.14899
   Sapienza P, 2009, P NATL ACAD SCI USA, V106, P15268, DOI 10.1073/pnas.0907352106
   Smith LB, 2014, SEMIN CELL DEV BIOL, V30, P2, DOI 10.1016/j.semcdb.2014.02.012
   STEPAN JJ, 1989, J CLIN ENDOCR METAB, V69, P523
   Üçer O, 2014, TURK J UROL, V40, P170, DOI 10.5152/tud.2013.97752
   Vermeulen A., 1999, Journal of Endocrinological Investigation, V22, P110
   Vigen R, 2013, JAMA-J AM MED ASSOC, V310, P1829, DOI 10.1001/jama.2013.280386
   Walsh TJ, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0199194
   Wang C, 2008, EUR J ENDOCRINOL, V159, P507, DOI 10.1530/EJE-08-0601
   Welker KM, 2014, PHYSIOL BEHAV, V129, P230, DOI 10.1016/j.physbeh.2014.02.057
   Xu HY, 2019, ASIAN J ANDROL, V21, P109, DOI 10.4103/aja.aja_83_18
   Xu L, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-108
   Yassin A, 2019, DIABETES CARE, V42, P1104, DOI 10.2337/dc18-2388
   Yildirim BO, 2012, PSYCHIAT RES, V200, P984, DOI 10.1016/j.psychres.2012.07.044
   Zarrour FA, 2009, J PSYCHIATR PRACT, V15, P289, DOI 10.1097/01.pra.0000358315.88931.fc
NR 78
TC 0
Z9 0
U1 1
U2 2
PU POZNAN UNIV MEDICAL SCIENCES
PI Poznan
PA 10 Fredry Street, Poznan, POLAND
SN 2353-9798
EI 2353-9801
J9 J MED SCI-POLAND
JI J. Med. Sci.
PY 2024
VL 93
IS 1
BP 57
EP 68
DI 10.20883/medical.e856
PG 12
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine; Research & Experimental Medicine
GA QS1N9
UT WOS:001222769400001
OA gold
DA 2025-06-11
ER

PT J
AU Chaudhary, K
   Malhotra, K
   Sowers, J
   Aroor, A
AF Chaudhary, Kunal
   Malhotra, Kunal
   Sowers, James
   Aroor, Annayya
TI Uric Acid - Key Ingredient in the Recipe for Cardiorenal Metabolic
   Syndrome
SO CARDIORENAL MEDICINE
LA English
DT Review
DE Uric acid; Fructose; Cardiorenal metabolic syndrome; Chronic kidney
   disease
ID CHRONIC KIDNEY-DISEASE; INSULIN-RESISTANCE; DIABETES-MELLITUS;
   BLOOD-PRESSURE; ENDOTHELIAL FUNCTION; DIETARY FRUCTOSE; HEART-FAILURE;
   HYPERURICEMIA; ALLOPURINOL; HYPERTENSION
AB Elevated serum uric acid levels are a frequent finding in persons with obesity, hypertension, cardiovascular and kidney disease as well as in those with the cardiorenal metabolic syndrome (CRS). The increased consumption of a fructose-rich Western diet has contributed to the increasing incidence of the CRS, obesity and diabetes especially in industrialized populations. There is also increasing evidence that supports a causal role of high dietary fructose driving elevations in uric acid in association with the CRS. Animal and epidemiological studies support the notion that elevated serum uric acid levels play an important role in promoting insulin resistance and hypertension and suggest potential pathophysiological mechanisms that contribute to the development of the CRS and associated cardiovascular disease and chronic kidney disease. To this point, elevated serum levels of uric acid appear to contribute to impaired nitric oxide production/endothelial dysfunction, increased vascular stiffness, inappropriate activation of the renin-angiotensin-aldosterone system, enhanced oxidative stress, and maladaptive immune and inflammatory responses. These abnormalities, in turn, promote vascular, cardiac and renal fibrosis as well as associated functional abnormalities. Small clinical trials have suggested that uric acid-lowering therapies may be beneficial in such patients; however, a consensus on the treatment of asymptomatic hyperuricemia is lacking. Larger randomized controlled trials need to be performed in order to critically evaluate the beneficial effect of lowering serum uric acid in patients with the CRS and those with diabetes and/or hypertension. (C) 2013 S. Karger AG, Basel
C1 [Chaudhary, Kunal; Sowers, James; Aroor, Annayya] Univ Missouri, Harry S Truman Vet Hosp, Columbia, MO USA.
   [Chaudhary, Kunal; Malhotra, Kunal] Univ Missouri, Dept Med, Div Endocrinol, Columbia, MO USA.
   [Sowers, James; Aroor, Annayya] Univ Missouri, Div Endocrinol, Columbia, MO USA.
   [Sowers, James] Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; University of Missouri
   System; University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia
RP Aroor, A (corresponding author), D109 Diabet Ctr UHC, 1 Hosp Dr, Columbia, MO 65212 USA.
EM aroora@health.missouri.edu
RI Malhotra, Kunal/R-2228-2018
OI Malhotra, Kunal/0000-0002-3209-8140
FU National Institutes of Health [R01-HL73101, R01-HL1079100]; Veterans
   Affairs Merit System [0018]
FX This research was supported by the National Institutes of Health
   (R01-HL73101 and R01-HL1079100) and Veterans Affairs Merit System 0018.
   The authors wish to thank Brenda Hunter for her assistance.
CR Aroor AR, 2012, HEART FAIL CLIN, V8, P609, DOI 10.1016/j.hfc.2012.06.005
   Aroor AR, 2013, METABOLISM
   Baldwin W, 2011, DIABETES, V60, P1258, DOI 10.2337/db10-0916
   Bomback AS, 2010, KIDNEY INT, V77, P609, DOI 10.1038/ki.2009.500
   CANNON PJ, 1966, NEW ENGL J MED, V275, P457, DOI 10.1056/NEJM196609012750902
   Carnethon MR, 2003, AM J EPIDEMIOL, V158, P1058, DOI 10.1093/aje/kwg260
   Caulfield MJ, 2008, PLOS MED, V5, P1509, DOI 10.1371/journal.pmed.0050197
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Chen X, 2010, AM J HYPERTENS, V23, P387, DOI 10.1038/ajh.2009.277
   Choi HK, 2007, AM J MED, V120, P442, DOI 10.1016/j.amjmed.2006.06.040
   Doehner W, 2002, CIRCULATION, V105, P2619, DOI 10.1161/01.CIR.0000017502.58595.ED
   FACCHINI F, 1991, JAMA-J AM MED ASSOC, V266, P3008, DOI 10.1001/jama.266.21.3008
   Farquharson CA, 2002, CIRCULATION, V106, P221, DOI 10.1161/01.CIR.0000022140.61460.1D
   Feig DI, 2008, JAMA-J AM MED ASSOC, V300, P924, DOI 10.1001/jama.300.8.924
   Feig DI, 2003, HYPERTENSION, V42, P247, DOI 10.1161/01.HYP.0000085858.66548.59
   FIASCHI E, 1977, METABOLISM, V26, P1219, DOI 10.1016/0026-0495(77)90114-7
   Flegal KM, 2010, JAMA-J AM MED ASSOC, V303, P235, DOI 10.1001/jama.2009.2014
   Ford ES, 2007, CIRCULATION, V115, P2526, DOI 10.1161/CIRCULATIONAHA.106.657627
   Gagliardi ACM, 2009, ATHEROSCLEROSIS, V202, P11, DOI 10.1016/j.atherosclerosis.2008.05.022
   Goicoechea M, 2010, CLIN J AM SOC NEPHRO, V5, P1388, DOI 10.2215/CJN.01580210
   Gómez-Marcos MA, 2013, AM J HYPERTENS, V26, P599, DOI 10.1093/ajh/hps097
   GUTMAN AB, 1968, AM J MED, V45, P756, DOI 10.1016/0002-9343(68)90209-X
   Havel PJ, 2005, NUTR REV, V63, P133, DOI [10.1301/nr.2005.may.133-157, 10.1111/j.1753-4887.2005.tb00132.x]
   Hayden Melvin R, 2004, Nutr Metab (Lond), V1, P10, DOI 10.1186/1743-7075-1-10
   Iribarren C, 1996, ANN EPIDEMIOL, V6, P331, DOI 10.1016/S1047-2797(96)00052-X
   Ishizaka N, 2007, ATHEROSCLEROSIS, V192, P131, DOI 10.1016/j.atherosclerosis.2006.04.016
   Jalal DI, 2013, AM J KIDNEY DIS, V61, P134, DOI 10.1053/j.ajkd.2012.07.021
   Johnson RJ, 2007, AM J CLIN NUTR, V86, P899
   Kanbay M, 2011, CLIN J AM SOC NEPHRO, V6, P1887, DOI 10.2215/CJN.11451210
   Kang DH, 2002, J AM SOC NEPHROL, V13, P2888, DOI 10.1097/01.ASN.0000034910.58454.FD
   Khitan Z, 2013, J NUTR METAB, V2013, DOI 10.1155/2013/682673
   Kim SY, 2009, ARTHRIT RHEUM-ARTHR, V61, P885, DOI 10.1002/art.24612
   Kodama S, 2009, DIABETES CARE, V32, P1737, DOI 10.2337/dc09-0288
   Lanaspa MA, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0047948, 10.1371/journal.pone.0048801]
   Liang J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051101
   Lim KH, 1998, AM J OBSTET GYNECOL, V178, P1067, DOI 10.1016/S0002-9378(98)70549-6
   Loeffler LF, 2012, HYPERTENSION, V59, P811, DOI 10.1161/HYPERTENSIONAHA.111.183244
   Madero M, 2009, AM J KIDNEY DIS, V53, P796, DOI 10.1053/j.ajkd.2008.12.021
   Malaguarnera M, 2009, EXPERT OPIN PHARMACO, V10, P737, DOI [10.1517/14656560902781972, 10.1517/14656560902781972 ]
   Manrique C, 2013, ENDOCRINOLOGY
   Marriott BP, 2009, J NUTR, V139, pS1228, DOI 10.3945/jn.108.098277
   Miao Y, 2011, HYPERTENSION, V58, P2, DOI 10.1161/HYPERTENSIONAHA.111.171488
   Niskanen L, 2006, DIABETES CARE, V29, P709, DOI 10.2337/diacare.29.03.06.dc05-1465
   Obermayr RP, 2008, J AM SOC NEPHROL, V19, P2407, DOI 10.1681/ASN.2008010080
   Ohno I, 2001, NEPHRON, V87, P333, DOI 10.1159/000045939
   Perez-Pozo SE, 2010, INT J OBESITY, V34, P454, DOI 10.1038/ijo.2009.259
   Ponte B, 2013, NEPHROL DIAL TRANSPL, V28, P2329, DOI 10.1093/ndt/gft206
   Romeo GR, 2012, ARTERIOSCL THROM VAS, V32, P1771, DOI 10.1161/ATVBAHA.111.241869
   Sanchez-Lozada LG, 2007, AM J PHYSIOL-RENAL, V292, pF423, DOI 10.1152/ajprenal.00124.2006
   Schiffrin EL, 2013, CAN J CARDIOL, V29, P543, DOI 10.1016/j.cjca.2012.06.009
   Shi YJ, 2012, KIDNEY BLOOD PRESS R, V35, P153, DOI 10.1159/000331453
   Siu YP, 2006, AM J KIDNEY DIS, V47, P51, DOI 10.1053/j.ajkd.2005.10.006
   Soltani Z, 2013, CURR HYPERTENS REP, V15, P175, DOI 10.1007/s11906-013-0344-5
   Sowers JR, 2013, HYPERTENSION, V61, P943, DOI 10.1161/HYPERTENSIONAHA.111.00612
   Sowers JR, 2011, CARDIORENAL MED, V1, P5, DOI 10.1159/000322822
   STEELE TH, 1973, ANN INTERN MED, V79, P734, DOI 10.7326/0003-4819-79-5-734
   Suliman ME, 2006, AM J KIDNEY DIS, V48, P761, DOI 10.1053/j.ajkd.2006.08.019
   Sundström J, 2005, HYPERTENSION, V45, P28, DOI 10.1161/01.HYP.0000150784.92944.9a
   Teff KL, 2009, J CLIN ENDOCR METAB, V94, P1562, DOI 10.1210/jc.2008-2192
   Terawaki H, 2013, CLIN EXP NEPHROL, V17, P549, DOI 10.1007/s10157-012-0742-z
   Thomas G, 2011, CLIN J AM SOC NEPHRO, V6, P2364, DOI 10.2215/CJN.02180311
   Tseng CH, 2005, KIDNEY INT, V68, P796, DOI 10.1111/j.1523-1755.2005.00459.x
   Tsushima Y, 2013, J BIOL CHEM
   Turak O, 2013, J CLIN HYPERTENS, V15, P7, DOI 10.1111/jch.12026
   Wang H, 2013, J RENAL NUTR, V23, P389, DOI 10.1053/j.jrn.2012.08.005
   Whelton A, 2011, JCR-J CLIN RHEUMATOL, V17, P7, DOI 10.1097/RHU.0b013e318204aab4
   Wright AF, 2010, KIDNEY INT, V78, P446, DOI 10.1038/ki.2010.206
NR 67
TC 158
Z9 176
U1 2
U2 39
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1664-3828
EI 1664-5502
J9 CARDIORENAL MED
JI CardioRenal Med.
PY 2013
VL 3
IS 3
BP 208
EP 220
DI 10.1159/000355405
PG 13
WC Cardiac & Cardiovascular Systems; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Urology & Nephrology
GA 236WZ
UT WOS:000325831500004
PM 24454316
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Kishi, T
   Hirooka, Y
   Konno, S
   Sunagawa, K
AF Kishi, Takuya
   Hirooka, Yoshitaka
   Konno, Satomi
   Sunagawa, Kenji
TI Angiotensin II receptor blockers improve endothelial dysfunction
   associated with sympathetic hyperactivity in metabolic syndrome
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE angiotensin II; autonomic function; endothelial function; metabolic
   syndrome
ID ROSTRAL VENTROLATERAL MEDULLA; DEPENDENT VASODILATION;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; NERVOUS-SYSTEM; BLOOD-PRESSURE;
   HEART-RATE; URIC-ACID; HYPERTENSION; OBESITY
AB Objectives: Renin-angiotensin system inhibitors are preferred for the treatment of hypertension with metabolic syndrome (MetS). Underlying endothelial dysfunction and sympathetic nervous system (SNS) activation are critically involved in the pathogenesis of hypertension in MetS. We investigated whether treatment with angiotensin II type 1 receptor blockers (ARBs) improves endothelial and autonomic function in patients with MetS.
   Methods and results: We conducted a prospective, randomized, open-label, blinded endpoint trial. Sixty patients with MetS were randomized into three treatment groups: telmisartan, candesartan, or diet therapy (control; n = 20 each), and treated for 6 months. To evaluate the endothelial function of forearm resistance arteries, blood flow and vascular resistance were measured using a strain-gauge plethysmograph during intra-arterial infusion of acetylcholine (ACh) or sodium nitroprusside (SNP). At 6 months, both telmisartan and candesartan comparably decreased blood pressure. Furthermore, ARB treatment ameliorated impaired forearm vasodilation in response to ACh. Telmisartan had a greater effect than candesartan on ACh-induced forearm vasodilation. In contrast, forearm vasodilation in response to SNP was comparable between the telmisartan and candesartan-treated groups. ARB treatment increased high-molecular-weight (HMW) adiponectin levels and baroreflex sensitivity, but telmisartan had a stronger effect than candesartan. In addition, only telmisartan treatment significantly decreased plasma norepinephrine concentrations, blood pressure variability, and heart rate variability based on spectral analysis.
   Conclusion: These findings indicate that ARBs improve impaired endothelial and baroreflex function, and increase HMW adiponectin levels in patients with MetS. Telmisartan exhibited more beneficial effects than candesartan, and only telmisartan reduced sympathetic hyperactivity, despite similar depressor effects.
C1 [Hirooka, Yoshitaka] Kyushu Univ, Grad Sch Med Sci, Dept Adv Cardiovasc Regulat & Therapeut, Higashi Ku, Fukuoka 8128582, Japan.
   [Kishi, Takuya] Kyushu Univ, Grad Sch Med Sci, Dept Adv Therapeut Cardiovasc Dis, Fukuoka 8128582, Japan.
   [Konno, Satomi; Sunagawa, Kenji] Kyushu Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Fukuoka 8128582, Japan.
C3 Kyushu University; Kyushu University; Kyushu University
RP Hirooka, Y (corresponding author), Kyushu Univ, Grad Sch Med Sci, Dept Adv Cardiovasc Regulat & Therapeut, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan.
EM hyoshi@cardiol.med.kyushu-u.ac.jp
RI Kishi, Takuya/ITU-1075-2023
FU Japan Society for the Promotion of Science [B193290231]; Kimura Memorial
   Foundation Research Grant
FX The study was supported by a Grant-in-Aid for Scientific Research from
   the Japan Society for the Promotion of Science (B193290231) and in part
   by a Kimura Memorial Foundation Research Grant.
CR Bahia L, 2007, ATHEROSCLEROSIS, V195, P138, DOI 10.1016/j.atherosclerosis.2006.09.003
   EGASHIRA K, 1995, HYPERTENSION, V25, P201, DOI 10.1161/01.HYP.25.2.201
   Elliott WJ, 2007, LANCET, V369, P201, DOI 10.1016/S0140-6736(07)60108-1
   Fathi R, 2004, J AM COLL CARDIOL, V43, P616, DOI 10.1016/j.jacc.2003.09.042
   Frick M, 2005, J AM COLL CARDIOL, V46, P1006, DOI 10.1016/j.jacc.2005.05.070
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Gohlke P, 2001, J PHARMACOL EXP THER, V298, P62
   Grassi G, 2005, DIABETOLOGIA, V48, P1359, DOI 10.1007/s00125-005-1798-z
   Grassi G, 2009, HYPERTENSION, V54, P690, DOI 10.1161/HYPERTENSIONAHA.108.119883
   Grassi G, 2009, PROG CARDIOVASC DIS, V52, P31, DOI 10.1016/j.pcad.2009.05.007
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hamburg NM, 2008, AM J CARDIOL, V101, P82, DOI 10.1016/j.amjcard.2007.07.053
   Heusser K, 2010, HYPERTENSION, V55, P619, DOI 10.1161/HYPERTENSIONAHA.109.140665
   Hijmering ML, 2002, J AM COLL CARDIOL, V39, P683, DOI 10.1016/S0735-1097(01)01786-7
   Hilz MJ, 2010, J HYPERTENS, V28, P1438, DOI 10.1097/HJH.0b013e328336a077
   Hirooka Y, 2003, HYPERTENS RES, V26, P953, DOI 10.1291/hypres.26.953
   HIROOKA Y, 1994, CIRCULATION, V90, P658, DOI 10.1161/01.CIR.90.2.658
   Hirooka Y, 2010, CIRC J, V74, P827, DOI 10.1253/circj.CJ-10-0153
   Kataoka H, 2010, EUR J PHARMACOL, V636, P36, DOI 10.1016/j.ejphar.2010.03.025
   Kishi T, 2005, CIRCULATION, V111, P2741, DOI 10.1161/CIRCULATIONAHA.104.510248
   Kishi T, 2004, CIRCULATION, V109, P2357, DOI 10.1161/01.CIR.0000128695.49900.12
   Kishi T, 2008, CLIN EXP HYPERTENS, V30, P3, DOI 10.1080/10641960701813429
   Kishi T, 2010, HYPERTENSION, V55, P291, DOI 10.1161/HYPERTENSIONAHA.109.138636
   Kullo IJ, 2007, J AM COLL CARDIOL, V49, P1413, DOI 10.1016/j.jacc.2006.11.039
   Landsberg L, 2001, J HYPERTENS, V19, P523, DOI 10.1097/00004872-200103001-00001
   Lee ZSK, 2001, METABOLISM, V50, P135, DOI 10.1053/meta.2001.19502
   Lind L, 2008, ATHEROSCLEROSIS, V196, P795, DOI 10.1016/j.atherosclerosis.2007.01.014
   Lind L, 2011, CIRCULATION, V123, P1545, DOI 10.1161/CIRCULATIONAHA.110.984047
   Lindgren K, 2006, J HYPERTENS, V24, P143, DOI 10.1097/01.hjh.0000198024.91976.c2
   Mancia G, 2007, J HYPERTENS, V25, P909, DOI 10.1097/HJH.0b013e328048d004
   Nozoe M, 2008, J HYPERTENS, V26, P2176, DOI 10.1097/HJH.0b013e32830dd5d3
   Oda E, 2006, CIRC J, V70, P364, DOI 10.1253/circj.70.364
   Ogihara T, 2009, HYPERTENS RES, V32, P3, DOI 10.1038/hr.2008.15
   Ouchi N, 2003, HYPERTENSION, V42, P231, DOI 10.1161/01.HYP.0000083488.67550.B8
   PARATI G, 1988, HYPERTENSION, V12, P214, DOI 10.1161/01.HYP.12.2.214
   Persson PB, 2005, HYPERTENSION, V46, P1095, DOI 10.1161/01.HYP.0000187014.92384.a4
   Perticone F, 2001, CIRCULATION, V104, P191, DOI 10.1161/01.CIR.104.2.191
   Pscherer S, 2010, DIABETES CARE, V33, P914, DOI 10.2337/dc09-1381
   Rahmouni K, 2005, DIABETES, V54, P2012, DOI 10.2337/diabetes.54.7.2012
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Shimabukuro M, 2003, J CLIN ENDOCR METAB, V88, P3236, DOI 10.1210/jc.2002-021883
   Title LM, 2008, VASC MED, V13, P263, DOI 10.1177/1358863X08095154
   Toyama K, 2011, BIOCHEM BIOPH RES CO, V410, P508, DOI 10.1016/j.bbrc.2011.06.012
   Triposkiadis F, 2009, J AM COLL CARDIOL, V54, P1747, DOI 10.1016/j.jacc.2009.05.015
   Tsouli SG, 2006, METABOLISM, V55, P1293, DOI 10.1016/j.metabol.2006.05.013
   Virdis A, 2011, CURR HYPERTENS REP, V13, P276, DOI 10.1007/s11906-011-0207-x
   Wu HD, 1999, HEART VESSELS, V14, P143, DOI 10.1007/BF02482298
   Yoshida T, 2006, DIABETOLOGIA, V49, P3094, DOI 10.1007/s00125-006-0437-7
   Zoccali C, 2006, J AM SOC NEPHROL, V17, P1466, DOI 10.1681/ASN.2005090949
NR 50
TC 37
Z9 38
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD AUG
PY 2012
VL 30
IS 8
BP 1646
EP 1655
DI 10.1097/HJH.0b013e328355860e
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 973PE
UT WOS:000306371400022
PM 22728908
DA 2025-06-11
ER

PT J
AU Lopez-Huertas, E
AF Lopez-Huertas, Eduardo
TI The effect of EPA and DHA on metabolic syndrome patients: a systematic
   review of randomised controlled trials
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Review
DE systematic review; metabolic syndrome; very long chain n3 fatty acids;
   cardiovascular disease
ID N-3 FATTY-ACIDS; ENDOTHELIAL ADHESION MOLECULES; SERUM AMYLOID-A;
   DIETARY-FAT; CARDIOVASCULAR-DISEASE; FISH CONSUMPTION; OLEIC-ACID;
   DOCOSAHEXAENOIC ACIDS; LIPOPROTEIN PROFILE; OXIDATIVE STRESS
AB Metabolic syndrome (MS) is characterised by accumulation of CVD risk factors. The use of very long chain n-3 polyunsaturated fatty acids (VLC n3 PUFA) could potentially benefit MS by reducing risk factors. To better understand the possible VLC n3 PUFA benefits, the literature was systematically reviewed for randomised controlled trials (RCT) that published effects of VLC n3 PUFA on MS patients. 17 RCT fulfilled the inclusion criteria and were analysed for relevance to the research question. The available RCT convincingly show that the administration of VLC n3 PUFA doses. 1 g for at least 3 months produces a significant reduction of triglycerides ranging from 7% to 25 %. These results confirm the hypotriglyceridemic effect of VLC n3 PUFA in MS patients. The triglyceride lowering may produce further benefits by reducing the % of pro-atherogenic small dense LDL particles (sdLDL) and also perhaps by ameliorating the inflammatory process associated with MS. High doses of VLC n3 PUFA (>= 3 g/day) may produce further TAG reductions but could raise other risk factors such as LDL-C. No clear effects were found on other MS markers. The combination of VLC n3 PUFA plus a statin may be useful to prevent the occurrence of coronary events. More studies are needed using different amounts of VLC n3 PUFA, time lengths, dietary backgrounds and different profiles of MS patients before clear recommendations can be made.
C1 CSIC, Estn Expt Zaidin, Spanish Minist Econ Affairs & Competitiveness Pro, E-18008 Granada, Spain.
C3 Spanish Ministry of Economy & Competitiveness; Consejo Superior de
   Investigaciones Cientificas (CSIC); CSIC - Estacion Experimental del
   Zaidin (EEZ)
RP Lopez-Huertas, E (corresponding author), CSIC, Estn Expt Zaidin, Spanish Minist Econ Affairs & Competitiveness Pro, E-18008 Granada, Spain.
EM eduardo.lopezhuertas@eez.csic.es
RI LOPEZ-HUERTAS, EDUARDO/L-3156-2014
OI LOPEZ-HUERTAS, EDUARDO/0000-0003-3403-3399
CR [Anonymous], COCHRANE LIB
   [Anonymous], N 3 FATT AC HLTH BRI
   [Anonymous], NAT NUTR SURV JAP
   [Anonymous], INT J OBES LOND
   [Anonymous], 2010, FATS FATTY ACIDS HUM
   [Anonymous], 2007, J HYPERTENS
   Arterburn LM, 2006, AM J CLIN NUTR, V83, p1467S, DOI 10.1093/ajcn/83.6.1467S
   AUSTIN MA, 1988, JAMA-J AM MED ASSOC, V260, P1917
   Balk EM, 2006, ATHEROSCLEROSIS, V189, P19, DOI 10.1016/j.atherosclerosis.2006.02.012
   Baró L, 2003, CLIN NUTR, V22, P175, DOI 10.1054/clnu.2002.0620
   Basu S, 2008, ANTIOXID REDOX SIGN, V10, P1405, DOI 10.1089/ars.2007.1956
   Basu S, 2007, MED RES REV, V27, P435, DOI 10.1002/med.20098
   Benito P, 2006, CLIN NUTR, V25, P581, DOI 10.1016/j.clnu.2005.12.006
   Brady LM, 2004, P NUTR SOC, V63, P115, DOI 10.1079/PNS2003318
   Bresson JL, 2009, EFSA J, V7, DOI 10.2903/j.efsa.2009.1283
   Bresson JL, 2009, EFSA J, V7, DOI 10.2903/j.efsa.2009.1176
   Buckley R, 2004, BRIT J NUTR, V92, P477, DOI 10.1079/BJN20041235
   Carrero JJ, 2004, NUTRITION, V20, P521, DOI 10.1016/j.nut.2004.03.017
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Simao ANC, 2010, ARQ BRAS ENDOCRINOL, V54, P463, DOI 10.1590/S0004-27302010000500006
   Daviglus ML, 1997, NEW ENGL J MED, V336, P1046, DOI 10.1056/NEJM199704103361502
   DOLECEK TA, 1991, WORLD REV NUTR DIET, V66, P205
   Ebrahimi M, 2009, ACTA CARDIOL, V64, P321, DOI 10.2143/AC.64.3.2038016
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   Friedberg CE, 1998, DIABETES CARE, V21, P494, DOI 10.2337/diacare.21.4.494
   Galgani JE, 2008, BRIT J NUTR, V100, P471, DOI 10.1017/S0007114508894408
   Giugliano D, 2008, AM J CLIN NUTR, V87, P8, DOI 10.1093/ajcn/87.1.8
   Gorjao R, 2009, PHARMACOL THERAPEUT, V122, P56, DOI 10.1016/j.pharmthera.2009.01.004
   Griffin BA, 1999, P NUTR SOC, V58, P163, DOI 10.1079/PNS19990022
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Gulseth HL, 2010, BRIT J NUTR, V104, P160, DOI 10.1017/S0007114510000565
   Harris WS, 2007, PHARMACOL RES, V55, P217, DOI 10.1016/j.phrs.2007.01.013
   Harris WS, 1997, AM J CLIN NUTR, V65, P1645, DOI 10.1093/ajcn/65.5.1645S
   Hartweg J, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003205.pub2
   Hartweg J, 2009, CURR OPIN LIPIDOL, V20, P30, DOI 10.1097/MOL.0b013e328321b3be
   Hartwich J, 2010, SCAND J CLIN LAB INV, V70, P201, DOI 10.3109/00365511003663630
   Hartwich J, 2009, CLIN NUTR, V28, P510, DOI 10.1016/j.clnu.2009.04.016
   Jacobson TA, 2008, AM J CLIN NUTR, V87, p1981S, DOI 10.1093/ajcn/87.6.1981S
   Jiménez-Gómez Y, 2010, J NUTR, V140, P1595, DOI 10.3945/jn.109.120816
   Kolovou GD, 2005, CURR MED CHEM, V12, P1931, DOI 10.2174/0929867054546609
   Kris-Etherton PM, 2003, ARTERIOSCL THROM VAS, V23, P151, DOI 10.1161/01.ATV.0000057393.97337.AE
   Kris-Etherton PM, 2002, CIRCULATION, V106, P2747, DOI 10.1161/01.CIR.0000038493.65177.94
   KROMHOUT D, 1995, INT J EPIDEMIOL, V24, P340, DOI 10.1093/ije/24.2.340
   KROMHOUT D, 1985, NEW ENGL J MED, V312, P1205, DOI 10.1056/NEJM198505093121901
   Lopez-Huertas E, 2010, PHARMACOL RES, V61, P200, DOI 10.1016/j.phrs.2009.10.007
   Mancia G, 2007, J HYPERTENS, V25, P1751, DOI 10.1097/HJH.0b013e3282f0580f
   Masson D, 2009, J LIPID RES, V50, pS201, DOI 10.1194/jlr.R800061-JLR200
   Matsuzawa Y, 2004, ARTERIOSCL THROM VAS, V24, P29, DOI 10.1161/01.ATV.0000099786.99623.EF
   Melanson EL, 2009, ANN NUTR METAB, V55, P229, DOI 10.1159/000229004
   Montegaard C, 2010, J NUTR, V140, P38, DOI 10.3945/jn.109.111427
   Montori VM, 2000, DIABETES CARE, V23, P1407, DOI 10.2337/diacare.23.9.1407
   Mori TA, 2000, AM J CLIN NUTR, V71, P1085
   Mostad IL, 2009, METABOLISM, V58, P1753, DOI 10.1016/j.metabol.2009.06.003
   Murphy KJ, 2007, BRIT J NUTR, V97, P749, DOI 10.1017/S000711450747252X
   Nettleton JA, 2005, J AM DIET ASSOC, V105, P428, DOI 10.1016/j.jada.2004.11.029
   Ogasawara K, 2004, ATHEROSCLEROSIS, V174, P349, DOI 10.1016/j.atherosclerosis.2004.01.030
   Perez-Martinez P, 2010, ATHEROSCLEROSIS, V209, P533, DOI 10.1016/j.atherosclerosis.2009.09.023
   Petersson H, 2010, BRIT J NUTR, V104, P1357, DOI 10.1017/S000711451000228X
   Pickup JC, 2004, DIABETES CARE, V27, P813, DOI 10.2337/diacare.27.3.813
   Pockley AG, 2003, HYPERTENSION, V42, P235, DOI 10.1161/01.HYP.0000086522.13672.23
   Rizzo M, 2006, QJM-INT J MED, V99, P1, DOI 10.1093/qjmed/hci154
   Roche HM, 2005, P NUTR SOC, V64, P23, DOI 10.1079/PNS2004405
   Ruotolo Giacomo, 2002, Curr Cardiol Rep, V4, P494, DOI 10.1007/s11886-002-0113-6
   Saito Y, 2008, ATHEROSCLEROSIS, V200, P135, DOI 10.1016/j.atherosclerosis.2008.06.003
   Satoh N, 2007, DIABETES CARE, V30, P144, DOI 10.2337/dc06-1179
   Satoh N, 2009, HYPERTENS RES, V32, P1004, DOI 10.1038/hr.2009.145
   Shaw DI, 2009, BRIT J NUTR, V101, P750, DOI 10.1017/S0007114508039962
   Tulk HMF, 2009, METABOLISM, V58, P1709, DOI 10.1016/j.metabol.2009.05.031
   van Hees AMJ, 2010, INT J OBESITY, V34, P859, DOI 10.1038/ijo.2010.6
   Vessby B, 2001, DIABETOLOGIA, V44, P312, DOI 10.1007/s001250051620
   Warensjö E, 2005, DIABETOLOGIA, V48, P1999, DOI 10.1007/s00125-005-1897-x
   Woodman RJ, 2002, AM J CLIN NUTR, V76, P1007, DOI 10.1093/ajcn/76.5.1007
   Yamada H, 2008, ARTERIOSCL THROM VAS, V28, P2173, DOI 10.1161/ATVBAHA.108.171736
   ZILVERSMIT DB, 1979, CIRCULATION, V60, P473, DOI 10.1161/01.CIR.60.3.473
   Zimmet P, 2001, NATURE, V414, P782, DOI 10.1038/414782a
NR 76
TC 70
Z9 77
U1 0
U2 28
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD JUN
PY 2012
VL 107
SU 2
BP S185
EP S194
DI 10.1017/S0007114512001572
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 943PT
UT WOS:000304137500016
PM 22591892
OA Bronze
DA 2025-06-11
ER

PT J
AU Johnson, DW
   Armstrong, K
   Campbell, SB
   Mudge, DW
   Hawley, CM
   Coombes, JS
   Prins, JB
   Isbel, NM
AF Johnson, David W.
   Armstrong, Kirsten
   Campbell, Scott B.
   Mudge, David W.
   Hawley, Carmel M.
   Coombes, Jeff S.
   Prins, Johannes B.
   Isbel, Nicole M.
TI Metabolic syndrome in severe chronic kidney disease: Prevalence,
   predictors, prognostic significance and effects of risk factor
   modification
SO NEPHROLOGY
LA English
DT Article
DE haemodialysis; insulin resistance; obesity; outcome; peritoneal
   dialysis; randomized controlled trial
ID INSULIN-RESISTANCE; MORTALITY; EPIDEMIOLOGY; ADIPONECTIN; DEFINITION;
   OBESITY
AB Background: Metabolic syndrome (MS) is a significant risk factor for cardiovascular disease, mortality and chronic kidney disease (CKD) in the general population. However, the prevalence, predictors, prognostic value and treatment of MS in the CKD population have not been rigorously studied.
   Methods: The study involved 200 stages 4 and 5 CKD patients enrolled in a randomized controlled trial of intensive multiple risk factor modification (targeting hypercholesterolaemia, hyperhomocysteinaemia, anaemia and disordered bone mineral metabolism) versus usual care. Participants were followed for a median period of 22 months.
   Results: The overall prevalence of MS was 30.5%. MS was independently predicted by older age, peritoneal dialysis and Maori/Pacific Islander origin. When laboratory parameters were included as covariates, the only significant predictors of MS were higher serum malondialdehyde and lower serum adiponectin concentrations. MS was an independent predictor of time to composite end-point of cardiovascular death, acute coronary syndrome, revascularization, non-fatal stroke and amputation (adjusted hazard ratio 2.46, 95% Cl 1.17-5.18). No significant difference in cardiovascular event-free survival was observed in those allocated to intensive risk factor modification compared with usual care.
   Conclusion: Metabolic syndrome occurs in 30.5% of stages 4 and 5 CKD patients and is associated with older age, peritoneal dialysis, ethnicity, increased oxidative stress, lower serum adiponectin concentrations and a significantly increased risk of future cardiovascular events. Intervention strategies targeting hypercholesterolaemia, hyperhomocysteinaemia, anaemia and disordered bone mineral metabolism may not be effective in ameliorating the heightened cardiovascular risk of CKD patients with MS.
C1 Univ Queensland, Princess Alexandra Hosp, Dept Renal Med, Brisbane, Qld 4102, Australia.
   Univ Queensland, Princess Alexandra Hosp, Dept Endocrinol, Brisbane, Qld 4102, Australia.
   Univ Queensland, Sch Human Movement Studies, Brisbane, Qld, Australia.
C3 University of Queensland; Princess Alexandra Hospital; University of
   Queensland; Princess Alexandra Hospital; University of Queensland
RP Johnson, DW (corresponding author), Univ Queensland, Princess Alexandra Hosp, Dept Renal Med, Level 12,Ambulatory Renal & Transplant Serv Bldg,, Brisbane, Qld 4102, Australia.
EM david_johnson@health.qld.gov.au
RI Campbell, Scott/H-8286-2013; Prins, Johannes/I-3610-2019; Isbel,
   Nicole/G-5604-2011; Hawley, Carmel/C-4905-2011; Prins,
   Johannes/M-5884-2013; Johnson, David/F-2897-2011; Mudge,
   David/C-1438-2011; Coombes, Jeff/F-1764-2010
OI Hawley, Carmel/0000-0002-1392-5649; Prins, Johannes/0000-0001-9497-927X;
   Johnson, David/0000-0001-5491-3460; Mudge, David/0000-0002-4112-5550;
   Coombes, Jeff/0000-0002-6990-3596
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Anand SS, 2003, CIRCULATION, V108, P420, DOI 10.1161/01.CIR.0000080884.27358.49
   Armstrong KA, 2005, TRANSPLANTATION, V80, P937, DOI 10.1097/01.tp.0000173792.53561.b6
   Armstrong KA, 2005, AM J TRANSPLANT, V5, P2710, DOI 10.1111/j.1600-6143.2005.01073.x
   Balkau B, 1999, DIABETIC MED, V16, P442
   Beddhu S, 2005, AM J KIDNEY DIS, V46, P577, DOI 10.1053/j.ajkd.2005.06.014
   Carrero JJ, 2006, CONTRIB NEPHROL, V150, P144, DOI 10.1159/000093514
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Einhorn Daniel, 2003, Endocr Pract, V9, P237
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Gu DF, 2005, LANCET, V365, P1398, DOI 10.1016/S0140-6736(05)66375-1
   Guebre-Egziabher F, 2005, NEPHROL DIAL TRANSPL, V20, P129, DOI 10.1093/ndt/gfh568
   Hu G, 2004, ARCH INTERN MED, V164, P1066, DOI 10.1001/archinte.164.10.1066
   Huang JW, 2004, AM J KIDNEY DIS, V43, P1047, DOI 10.1053/j.ajkd.2004.02.017
   Isbel NM, 2006, AM HEART J, V151, P745, DOI 10.1016/j.ahj.2005.06.017
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Joshy Grace, 2006, N Z Med J, V119, pU1999
   Kalantar-Zadeh K, 2003, KIDNEY INT, V63, P793, DOI 10.1046/j.1523-1755.2003.00803.x
   Kurella M, 2005, J AM SOC NEPHROL, V16, P2134, DOI 10.1681/ASN.2005010106
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lastra Guido, 2006, Curr Diab Rep, V6, P207, DOI 10.1007/s11892-006-0036-5
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   MORRISON G, 1989, ANNU REV MED, V40, P163
   Reisin E, 2005, AM J MED SCI, V330, P269, DOI 10.1097/00000441-200512000-00003
   Reynolds K, 2005, AM J MED SCI, V330, P273, DOI 10.1097/00000441-200512000-00004
   Sarafidis PA, 2006, AM J NEPHROL, V26, P232, DOI 10.1159/000093632
   Scott CL, 2003, AM J CARDIOL, V92, p35I, DOI 10.1016/S0002-9149(03)00507-1
   Sim AS, 2003, J CHROMATOGR B, V785, P337, DOI 10.1016/S1570-0232(02)00956-X
   Tanaka H, 2006, KIDNEY INT, V69, P369, DOI 10.1038/sj.ki.5000050
   Zhang RB, 2005, AM J MED SCI, V330, P319, DOI 10.1097/00000441-200512000-00010
NR 31
TC 108
Z9 123
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1320-5358
EI 1440-1797
J9 NEPHROLOGY
JI Nephrology
PD AUG
PY 2007
VL 12
IS 4
BP 391
EP 398
DI 10.1111/j.1440-1797.2007.00804.x
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 194VV
UT WOS:000248372800013
PM 17635756
DA 2025-06-11
ER

PT J
AU Witt, SH
   Buchmann, AF
   Blomeyer, D
   Nieratschker, V
   Treutlein, J
   Esser, G
   Schmidt, MH
   Bidlingmaier, M
   Wiedemann, K
   Rietschel, M
   Laucht, M
   Wüst, S
   Zimmermann, US
AF Witt, Stephanie H.
   Buchmann, Arlette F.
   Blomeyer, Dorothea
   Nieratschker, Vanessa
   Treutlein, Jens
   Esser, Guenter
   Schmidt, Martin H.
   Bidlingmaier, Martin
   Wiedemann, Klaus
   Rietschel, Marcella
   Laucht, Manfred
   Wuest, Stefan
   Zimmermann, Ulrich S.
TI An interaction between a neuropeptide Y gene polymorphism and early
   adversity modulates endocrine stress responses
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE GxE interaction; Stress; HPA; Neuropeptide Y; Early adversity
ID PITUITARY-ADRENAL AXIS; CORTICOTROPIN-RELEASING HORMONE;
   GLUCOCORTICOID-RECEPTOR GENE; SEROTONIN TRANSPORTER GENE; PSYCHOSOCIAL
   STRESS; HPA AXIS; CHILDHOOD EXPERIENCES; METABOLIC SYNDROME; PERCEIVED
   STRESS; RESTRAINT STRESS
AB Interindividual variability in the regulation of the human stress system accounts for a part of the individual's liability to stress-related diseases. These differences are influenced by environmental and genetic factors. Early childhood adversity is a well-studied environmental factor affecting an individual's stress response which has been shown to be modulated by gene environment interaction (GxE). Neuropeptide Y (NPY) plays a role in stress regulation and genetic variation in NPY may influence stress responses. In this study, we analyzed the association of a common variant in the NPY gene promoter, rs16147, with cortisol and ACTH responses to acute psychosocial stress in young adults from the Mannheim Study of Children at Risk (MARS), an ongoing epidemiological cohort study following the outcome of early adversity from birth into adulthood. We found evidence of a GxE interaction between rs16147 and early adversity significantly affecting HPA axis responses to acute psychosocial stress. These findings suggest that the neurobiological mechanisms linking early adverse experience and later neuroendocrine stress regulation are modulated by a gene variant whose functional relevance is documented by increasing convergent evidence from in vitro, animal and human studies. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Buchmann, Arlette F.; Blomeyer, Dorothea; Schmidt, Martin H.; Laucht, Manfred] Cent Inst Mental Hlth Mannheim, Dept Child & Adolescent Psychiat & Psychotherapy, D-68159 Mannheim, Germany.
   [Witt, Stephanie H.; Nieratschker, Vanessa; Treutlein, Jens; Rietschel, Marcella; Wuest, Stefan] Cent Inst Mental Hlth Mannheim, Dept Genet Epidemiol Psychiat, D-68159 Mannheim, Germany.
   [Esser, Guenter; Laucht, Manfred] Univ Potsdam, Dept Psychol, Div Clin Psychol, Potsdam, Germany.
   [Bidlingmaier, Martin] Univ Munich, Med Klin Innenstadt, Munich, Germany.
   [Wiedemann, Klaus] Univ Hamburg, Dept Psychiat & Psychotherapy, Univ Med Ctr Eppendorf, Hamburg, Germany.
   [Zimmermann, Ulrich S.] Cent Inst Mental Hlth, Dept Addict Behav & Addict Med, D-68159 Mannheim, Germany.
   [Zimmermann, Ulrich S.] Tech Univ Dresden, Dept Psychiat & Psychotherapy, Univ Hosp Carl Gustav Carus, Dresden, Germany.
C3 Central Institute of Mental Health; Central Institute of Mental Health;
   University of Potsdam; University of Munich; University of Hamburg;
   University Medical Center Hamburg-Eppendorf; Central Institute of Mental
   Health; Technische Universitat Dresden; Carl Gustav Carus University
   Hospital
RP Laucht, M (corresponding author), Cent Inst Mental Hlth Mannheim, Dept Child & Adolescent Psychiat & Psychotherapy, J5, D-68159 Mannheim, Germany.
EM manfred.laucht@zi-mannheim.de
RI Zimmermann, Ulrich/B-9357-2011
OI Bidlingmaier, Martin/0000-0002-4681-6668; Wust,
   Stefan/0000-0002-2315-8949
FU NGFNplus; German Research Foundation DFG [SFB636/Z4]
FX Funding for this study was provided by NGFNplus and the German Research
   Foundation DFG SFB636/Z4; neither founding source had any further role
   in study design; in the collection, analysis and interpretation of data;
   in the writing of the report; and in the decision to submit the paper
   for publication.
CR Amstadter AB, 2010, DEPRESS ANXIETY, V27, P270, DOI 10.1002/da.20648
   Antonijevic IA, 2000, NEUROPHARMACOLOGY, V39, P1474, DOI 10.1016/S0028-3908(00)00057-5
   Bellingrath S, 2008, PSYCHONEUROENDOCRINO, V33, P1335, DOI 10.1016/j.psyneuen.2008.07.008
   Belsky J, 2009, MOL PSYCHIATR, V14, P746, DOI 10.1038/mp.2009.44
   Benarroch EE, 2009, NEUROLOGY, V72, P1016, DOI 10.1212/01.wnl.0000345258.18071.54
   Björntorp P, 2000, BRIT J NUTR, V83, pS49, DOI 10.1017/S0007114500000957
   Bogdan R, 2009, PSYCHOL MED, V39, P211, DOI 10.1017/S0033291708003619
   Bornstein SR, 2008, TRENDS ENDOCRIN MET, V19, P175, DOI 10.1016/j.tem.2008.01.009
   BROQUA P, 1995, BEHAV PHARMACOL, V6, P215
   Buckland PR, 2005, HUM MUTAT, V26, P214, DOI 10.1002/humu.20207
   Caspi A, 2005, BIOL PSYCHIAT, V57, P1117, DOI 10.1016/j.biopsych.2005.01.026
   Caspi A, 2003, SCIENCE, V301, P386, DOI 10.1126/science.1083968
   Caspi A, 2010, AM J PSYCHIAT, V167, P509, DOI 10.1176/appi.ajp.2010.09101452
   Chapman DP, 2004, J AFFECT DISORDERS, V82, P217, DOI 10.1016/j.jad.2003.12.013
   Chrousos George P, 2005, Sci STKE, V2005, ppe48, DOI 10.1126/stke.3042005pe48
   Chrousos GP, 2009, NAT REV ENDOCRINOL, V5, P374, DOI 10.1038/nrendo.2009.106
   Dallman MF, 2003, P NATL ACAD SCI USA, V100, P11696, DOI 10.1073/pnas.1934666100
   de Kloet ER, 2005, NAT REV NEUROSCI, V6, P463, DOI 10.1038/nrn1683
   DeRijk RH, 2009, NEUROIMMUNOMODULAT, V16, P340, DOI 10.1159/000216192
   Dimitrov EL, 2007, ENDOCRINOLOGY, V148, P3666, DOI 10.1210/en.2006-1730
   Eaton K, 2007, CURR TOP MED CHEM, V7, P1645, DOI 10.2174/156802607782341037
   Edwards VJ, 2003, AM J PSYCHIAT, V160, P1453, DOI 10.1176/appi.ajp.160.8.1453
   Federenko IS, 2006, PSYCHOL MED, V36, P375, DOI 10.1017/S0033291705006616
   Federenko IS, 2004, J CLIN ENDOCR METAB, V89, P6244, DOI 10.1210/jc.2004-0981
   Gray WP, 2008, MOL CELL ENDOCRINOL, V288, P52, DOI 10.1016/j.mce.2008.02.021
   Heilig M, 2004, NEUROPEPTIDES, V38, P213, DOI 10.1016/j.npep.2004.05.002
   HEILIG M, 1994, TRENDS NEUROSCI, V17, P80, DOI 10.1016/0166-2236(94)90079-5
   HEILIG M, 1989, PSYCHOPHARMACOLOGY, V98, P524, DOI 10.1007/BF00441953
   Heim C, 2008, PSYCHONEUROENDOCRINO, V33, P693, DOI 10.1016/j.psyneuen.2008.03.008
   Held K, 2006, PSYCHONEUROENDOCRINO, V31, P100, DOI 10.1016/j.psyneuen.2005.05.015
   Hellhammer DH, 2009, PSYCHONEUROENDOCRINO, V34, P163, DOI 10.1016/j.psyneuen.2008.10.026
   Holsboer F, 2001, J AFFECT DISORDERS, V62, P77, DOI 10.1016/S0165-0327(00)00352-9
   Horsell A, 1999, NEUROREPORT, V10, P3003, DOI 10.1097/00001756-199909290-00024
   Ising M, 2008, EUR J NEUROSCI, V28, P389, DOI 10.1111/j.1460-9568.2008.06332.x
   Itokawa M, 2003, NEUROSCI LETT, V347, P202, DOI 10.1016/S0304-3940(03)00718-3
   Jiménez-Vasquez PA, 2007, EUR NEUROPSYCHOPHARM, V17, P298, DOI 10.1016/j.euroneuro.2006.06.011
   KARL T, 2010, NEUROPEPTIDES, P44
   KIRSCHBAUM C, 1993, NEUROPSYCHOBIOLOGY, V28, P76, DOI 10.1159/000119004
   Kudielka B. M., 2007, TRIER SOCIAL STRESS, V2, P776
   Kudielka BM, 2009, PSYCHONEUROENDOCRINO, V34, P2, DOI 10.1016/j.psyneuen.2008.10.004
   Kumsta R, 2007, BIOL PSYCHIAT, V62, P863, DOI 10.1016/j.biopsych.2007.04.013
   Kuo LE, 2008, ANN NY ACAD SCI, V1148, P232, DOI 10.1196/annals.1410.035
   Kupper N, 2005, PSYCHONEUROENDOCRINO, V30, P857, DOI 10.1016/j.psyneuen.2005.04.003
   Ladd CO, 2000, PROG BRAIN RES, V122, P81
   Larhammar D, 2004, NEUROPEPTIDES, V38, P141, DOI 10.1016/j.npep.2004.06.002
   Laucht M, 2000, J AM ACAD CHILD PSY, V39, P1229, DOI 10.1097/00004583-200010000-00009
   Laucht M, 1997, J CHILD PSYCHOL PSYC, V38, P843, DOI 10.1111/j.1469-7610.1997.tb01602.x
   Lindell SG, 2010, ARCH GEN PSYCHIAT, V67, P423, DOI 10.1001/archgenpsychiatry.2010.23
   McEwen BS, 2010, ANN NY ACAD SCI, V1186, P190, DOI 10.1111/j.1749-6632.2009.05331.x
   Morales-Medina JC, 2010, BRAIN RES, V1314, P194, DOI 10.1016/j.brainres.2009.09.077
   Morgan CA, 2002, BIOL PSYCHIAT, V52, P136, DOI 10.1016/S0006-3223(02)01319-7
   MULLER R, 1991, CHANGING TRENDS CONS
   Nikisch G, 2005, INT J NEUROPSYCHOPH, V8, P403, DOI 10.1017/S1461145705005158
   Pariante CM, 2008, TRENDS NEUROSCI, V31, P464, DOI 10.1016/j.tins.2008.06.006
   Parker AJR, 2001, PSYCHOL MED, V31, P1331, DOI 10.1017/S0033291701004664
   Paschos KA, 2009, CNS DRUGS, V23, P755, DOI 10.2165/11310830-000000000-00000
   Redrobe JP, 2002, LIFE SCI, V71, P2921, DOI 10.1016/S0024-3205(02)02159-8
   Risch N, 2009, JAMA-J AM MED ASSOC, V301, P2462, DOI 10.1001/jama.2009.878
   RUTTER M, 1977, PSYCHIAT DISORDER EC, P173
   Sajdyk TJ, 2004, NEUROPEPTIDES, V38, P225, DOI 10.1016/j.npep.2004.05.006
   Sánchez MM, 2001, DEV PSYCHOPATHOL, V13, P419, DOI 10.1017/S0954579401003029
   Schmidt MV, 2008, J ENDOCRINOL, V197, P421, DOI 10.1677/JOE-07-0634
   Shah SH, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000318
   Sommer WH, 2010, HUM MUTAT, V31, pE1594, DOI 10.1002/humu.21299
   Thorsell A, 2000, P NATL ACAD SCI USA, V97, P12852, DOI 10.1073/pnas.220232997
   Thorsell A, 1998, REGUL PEPTIDES, V75-6, P247, DOI 10.1016/S0167-0115(98)00075-5
   Thorsell A, 2008, ANN NY ACAD SCI, V1148, P136, DOI 10.1196/annals.1410.083
   Uher R, 2010, MOL PSYCHIATR, V15, P18, DOI 10.1038/mp.2009.123
   Wittchen H., 1997, Structured Clinical Interview for DSM-IV (SCID), Axis 1 Disorders
   Wüst S, 2009, PSYCHONEUROENDOCRINO, V34, P972, DOI 10.1016/j.psyneuen.2009.01.011
   Wüst S, 2000, PSYCHONEUROENDOCRINO, V25, P707, DOI 10.1016/S0306-4530(00)00021-4
   Wüst S, 2004, J CLIN ENDOCR METAB, V89, P565, DOI 10.1210/jc.2003-031148
   Yehuda R, 1997, ANN NY ACAD SCI, V821, P57, DOI 10.1111/j.1749-6632.1997.tb48269.x
   Zhou ZF, 2008, NATURE, V452, P997, DOI 10.1038/nature06858
   Zimmermann U, 2004, NEUROPSYCHOPHARMACOL, V29, P1156, DOI 10.1038/sj.npp.1300395
NR 75
TC 41
Z9 43
U1 0
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD AUG
PY 2011
VL 36
IS 7
BP 1010
EP 1020
DI 10.1016/j.psyneuen.2010.12.015
PG 11
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 807VQ
UT WOS:000293931500008
PM 21273004
DA 2025-06-11
ER

PT J
AU Omidian, A
   Pourfarzam, M
   Ghanadian, SM
   Zadhoush, F
AF Omidian, Amin
   Pourfarzam, Morteza
   Ghanadian, Seyed Mostafa
   Zadhoush, Fouzieh
TI Determination of plasma and erythrocyte levels of copper, magnesium and
   zinc by atomic absorption spectrometry in type-2 diabetes mellitus
   patients with metabolic syndrome
SO RESEARCH IN PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Atomic absorption spectrometry; Copper; Diabetes mellitus; Magnesium;
   Metabolic syndrome; Zinc
ID TRACE-ELEMENTS; BIOLOGICAL SAMPLES; OXIDATIVE STRESS; SERUM ZINC; BLOOD;
   CHROMIUM; ADULTS; IRON
AB Background and purpose: Imbalance in blood levels of trace elements is independent risk factor for metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and its complications. This study investigated plasma and erythrocyte levels of copper, magnesium, zinc, and their correlations with biochemical components of the MetS in T2DM patients compared to the healthy controls.& nbsp;Experimental approach: Forty men recently diagnosed T2DM with MetS without complications and thirty six age-matched healthy controls were enrolled in this cross-sectional study. Plasma and erythrocyte levels of selected elements were measured by graphite furnace atomic absorption spectroscopy.& nbsp;Findings/Results: The results of the present study showed significantly lower plasma levels of copper, magnesium, and zinc and lower erythrocytes copper in the patients' group compared to the controls; while erythrocyte levels of magnesium and zinc were not significantly different between the two groups. Significant negative correlations were observed between plasma levels of copper with waist and hip circumferences, waist to hip ratio, systolic and diastolic blood pressures, fasting blood glucose, and glycated hemoglobin levels in all subjects; while erythrocyte copper levels showed significant negative correlation with triglyceride, and erythrocyte zinc was positively correlated with diastolic blood pressure and negatively with triglyceride.& nbsp;Conclusion and implications: Alterations of trace elements may have a significant role in the pathogenesis of MetS and T2DM patients. It is suggested that the body status of copper, magnesium, and zinc might be significantly correlated with components of MetS in T2DM patients; and plasma copper levels may be correlated with complications of type 2 diabetes mellitus.
C1 [Omidian, Amin; Pourfarzam, Morteza; Zadhoush, Fouzieh] Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Clin Biochem, Esfahan, Iran.
   [Ghanadian, Seyed Mostafa] Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Pharmacognosy, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences
RP Zadhoush, F (corresponding author), Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Clin Biochem, Esfahan, Iran.
EM f.zadhoush@pharm.mui.ac.ir
RI zadhoush, fouzieh/S-4976-2018
FU Vice Chancellery for Research, Isfahan University of Medical Sciences,
   Isfahan, I.R. Iran [398690]
FX This study was financially supported by Vice Chancellery for Research,
   Isfahan University of Medical Sciences, Isfahan, I.R. Iran under Grant
   No. 398690. The authors would like to thank all the subjects who
   participated in this study.
CR Abolbashari S, 2019, J BLOOD MED, V10, P29, DOI 10.2147/JBM.S184913
   Ahn BI, 2014, BIOL TRACE ELEM RES, V160, P169, DOI 10.1007/s12011-014-0045-1
   [Anonymous], 2016, DIABETES CARE, V39, pS1, DOI [10.2337/dc19-Sint01, 10.2337/dc16-S001, 10.2337/dc19-SINT01, 10.2337/dc20-Sint, 10.2337/dc20-SINT]
   Basaki M, 2012, BIOL TRACE ELEM RES, V148, P161, DOI 10.1007/s12011-012-9360-6
   Burtis CA, 2014, TIETZ FUNDAMENTALS C, V7th, P1756
   CHEN MD, 1995, BIOL TRACE ELEM RES, V50, P119, DOI 10.1007/BF02789414
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   DHAESE PC, 1992, CLIN CHEM, V38, P2439
   Eaton JW, 2002, MOL CELL BIOCHEM, V234, P135, DOI 10.1023/A:1015988817587
   Galhardi CM, 2004, FOOD CHEM TOXICOL, V42, P2053, DOI 10.1016/j.fct.2004.07.020
   Guariguata L, 2014, DIABETES RES CLIN PR, V103, P137, DOI 10.1016/j.diabres.2013.11.002
   Guerrero-Romero F, 2006, DIABETES-METAB RES, V22, P471, DOI 10.1002/dmrr.644
   Hezarkhani S, 2012, RES PHARM SCI, V7, pS878
   Hulanicki A, 1995, SPECTROCHIM ACTA B, V50, P1717, DOI 10.1016/0584-8547(95)01376-8
   Kazi TG, 2008, BIOL TRACE ELEM RES, V122, P1, DOI 10.1007/s12011-007-8062-y
   Kruse-Jarres JD, 2000, J TRACE ELEM MED BIO, V14, P21, DOI 10.1016/S0946-672X(00)80019-X
   La SA, 2016, BIOL TRACE ELEM RES, V170, P33, DOI 10.1007/s12011-015-0446-9
   MARTIN MT, 1988, METHOD ENZYMOL, V158, P365, DOI 10.1016/0076-6879(88)58068-0
   Masood N, 2009, JCPSP-J COLL PHYSICI, V19, P483, DOI 08.2009/JCPSP.483486
   Obeid O, 2008, BIOL TRACE ELEM RES, V123, P58, DOI 10.1007/s12011-008-8112-0
   Ostovar Rahim, 2017, Electron Physician, V9, P5402, DOI 10.19082/5402
   Pizent A, 2010, J NUTR HEALTH AGING, V14, P866, DOI 10.1007/s12603-010-0139-1
   Pourmoradnasseri Mozhgan, 2016, arXiv
   Prohaska C, 2000, FRESEN J ANAL CHEM, V368, P627, DOI 10.1007/s002160000520
   Rifai N, 2018, TIETZ TXB CLIN CHEM, V6th, P1745
   Saha-Roy S, 2014, J DRUG DELIV THER, V4, P70
   Samimi F, 2019, RES PHARM SCI, V14, P524, DOI 10.4103/1735-5362.272561
   Sobczak AIS, 2019, BIOMETALS, V32, P123, DOI 10.1007/s10534-018-00167-z
   Sohrevardi S, 2012, RES PHARM SCI, V7, pS95
   SUAREZ A, 1995, DIABETOLOGIA, V38, P1262
   Viktorínová A, 2009, METABOLISM, V58, P1477, DOI 10.1016/j.metabol.2009.04.035
   WHITEHOUSE RC, 1982, CLIN CHEM, V28, P475
   Yu YH, 2012, NUTR RES, V32, P71, DOI 10.1016/j.nutres.2011.12.004
   Zadhoush F, 2015, J RES MED SCI, V20, P763, DOI 10.4103/1735-1995.168383
   Zhang HM, 2017, J TRACE ELEM MED BIO, V40, P91, DOI 10.1016/j.jtemb.2016.12.017
NR 35
TC 10
Z9 10
U1 1
U2 10
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 1735-5362
EI 1735-9414
J9 RES PHARM SCI
JI Res. Pharm. Sci.
PD JAN-FEB
PY 2022
VL 17
IS 1
BP 86
EP 98
DI 10.4103/1735-5362.329929
PG 13
WC Chemistry, Medicinal
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA WY9TQ
UT WOS:000719619600009
PM 34909047
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhao, LQ
   Liang, SY
   Li, CJ
   Yu, JY
   Zou, LH
   Xv, WC
   Qian, G
   Zhang, Y
   Huang, YX
   Li, YQ
AF Zhao, Liqin
   Liang, Shiyi
   Li, Chijian
   Yu, Jianye
   Zou, Lihao
   Xv, Weicheng
   Qian, Ge
   Zhang, Ying
   Huang, Yuxiang
   Li, Yongqiang
TI Ratios of peripheral blood mononuclear cells to lncRNA steroid receptor
   RNA activator as new indicators of metabolic syndrome
SO ENDOKRYNOLOGIA POLSKA
LA English
DT Article
DE lncRNA; steroid receptor RNA activator; peripheral blood mononuclear
   cells; metabolic syndrome; biomarkers
ID EXPRESSION
AB Introduction: Metabolic syndrome (MetS) is a clinical syndrome with several characteristics. Steroid receptor RNA activator (SRA) is a long non-coding RNA (lncRNA), which can increase the expression of steroid receptor-dependent gene. This study aimed to explore the changes in metabolic parameters and the predictive value of the peripheral blood mononuclear cells (PBMCs) to SRA ratios as new indicators in subjects with and without MetS in southern China.
   Material and methods: There were 81 participants (39 with MetS and 42 without MetS) in this cross-sectional study. The expression of lncRNAs in PBMCs was evaluated by quantitative reverse transcription polymerase chain reaction (qRT-PCR). The risks of SRA and PBMCs to SRA ratios contributing to the presence of MetS were estimated by univariate and multivariate logistic regression models. The area under the receiver (AUC) operating characteristic curve was employed to evaluate diagnostic accuracy.
   Results: MetS was positively correlated with cortisol, interleukin 6 (IL-6), white blood cell to SRA ratio (WTSR), lymphocyte to SRA ratio (LTSR), monocyte to SRA ratio (MTSR), and PBMC to SRA ratio (PTSR). A receiver operating characteristic (ROC) curve analysis was performed to assess the value of LTSR (OR: 0.722; p < 0.001) for predicting MetS. The area under the curve yielded a cut-off value of 0.483, with a sensitivity of 76.9% and a specificity of 71.4% (p < 0.001).
   Conclusion: In summary, SRA in PBMCs may be an important biomarker of stress reaction and may play a role in vulnerability to MetS. Also, the lymphocyte to SRA ratio demonstrated high accuracy in the diagnosis of MetS.
C1 [Zhao, Liqin] Southern Med Univ, Ctr Hlth Management, Affiliated Hosp 3, Guangzhou, Peoples R China.
   [Liang, Shiyi; Li, Chijian; Yu, Jianye; Zou, Lihao; Xv, Weicheng; Qian, Ge; Zhang, Ying] Southern Med Univ, Inst Nephrol & Urol, Dept Nephrol, Affiliated Hosp 3, Guangzhou, Peoples R China.
   [Huang, Yuxiang; Li, Yongqiang] Southern Med Univ, Dept Gen Med, Affiliated Hosp 3, Guangzhou, Peoples R China.
C3 Southern Medical University - China; Southern Medical University -
   China; Southern Medical University - China
RP Huang, YX; Li, YQ (corresponding author), Southern Med Univ, Dept Gen Med, Affiliated Hosp 3, Guangzhou, Peoples R China.
EM 1255856885@qq.com; liyongqiang851@163.com
FU President Foundation of The Third Affiliated Hospital of Southern
   Medical University [YQ2021016]; "Thirteenth Five-Year Plan" of Guangdong
   Province Educational Science [2020GXJK441]; Project of Traditional
   Chinese Medicine Bureau of Guangdong Province (CN) [20191228]; Science
   and Technology Planning Project of Huadu District, Guangzhou City
   [21-HDWS-059]
FX This work was supported by the President Foundation of The Third
   Affiliated Hospital of Southern Medical University(No. YQ2021016),
   "Thirteenth Five-Year Plan" of Guangdong Province Educational Science
   (No. 2020GXJK441), the Project of Traditional Chinese Medicine Bureau of
   Guangdong Province (CN) (No. 20191228 to ZY), Science and Technology
   Planning Project of Huadu District, Guangzhou City (No. 21-HDWS-059).
CR Caldwell KK, 2018, NEUROTOXICOL TERATOL, V66, P102, DOI 10.1016/j.ntt.2017.11.003
   Chatzopoulou A, 2015, ENDOCRINOLOGY, V156, P1757, DOI 10.1210/en.2014-1941
   Chen HS, 2019, DIABET METAB SYND OB, V12, P2117, DOI 10.2147/DMSO.S219363
   Dong J, 2017, J ATHEROSCLER THROMB, V24, P430, DOI 10.5551/jat.35923
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Huang YX, 2020, BIOMED RES INT, V2020, DOI 10.1155/2020/8159342
   Jiang BY, 2020, NEUROREPORT, V31, P48, DOI 10.1097/WNR.0000000000001367
   Juster RP, 2010, NEUROSCI BIOBEHAV R, V35, P2, DOI 10.1016/j.neubiorev.2009.10.002
   Lai XN, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21041193
   Lin WY, 2020, INT J BIOL SCI, V16, P1194, DOI 10.7150/ijbs.40769
   Liu C, 2016, CLIN CHIM ACTA, V459, P137, DOI 10.1016/j.cca.2016.06.004
   Liu S, 2014, J BIOL CHEM, V289, P13000, DOI 10.1074/jbc.M114.564658
   Lu JL, 2017, J CLIN ENDOCR METAB, V102, P507, DOI 10.1210/jc.2016-2477
   Michailidou Z, 2007, OBESITY, V15, P1155, DOI 10.1038/oby.2007.618
   Sathishkumar C, 2018, HUM GENOMICS, V12, DOI 10.1186/s40246-018-0173-3
   Sookoian S, 2011, CURR HYPERTENS REP, V13, P149, DOI 10.1007/s11906-010-0164-9
   Wang Minghan, 2005, Nutr Metab (Lond), V2, P3, DOI 10.1186/1743-7075-2-3
   Wang SS, 2017, J CELL MOL MED, V21, P3372, DOI 10.1111/jcmm.13240
   Whorwood CB, 2002, DIABETES, V51, P1066, DOI 10.2337/diabetes.51.4.1066
   Xu B, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0014199
NR 20
TC 0
Z9 0
U1 0
U2 3
PU VIA MEDICA
PI GDANSK
PA UL SWIETOKRZYSKA 73, 80-180 GDANSK, POLAND
SN 0423-104X
J9 ENDOKRYNOL POL
JI Endokrynol. Pol.
PY 2022
VL 73
IS 1
BP 81
EP 86
DI 10.5603/EP.a2021.0106
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 1T4GJ
UT WOS:000804688900011
PM 35119092
OA gold
DA 2025-06-11
ER

PT J
AU Scaini, G
   Quevedo, J
   Velligan, D
   Roberts, DL
   Raventos, H
   Walss-Bass, C
AF Scaini, Giselli
   Quevedo, Joao
   Velligan, Dawn
   Roberts, David L.
   Raventos, Henriette
   Walss-Bass, Consuelo
TI Second generation antipsychotic-induced mitochondrial alterations:
   Implications for increased risk of metabolic syndrome in patients with
   schizophrenia
SO EUROPEAN NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE Metabolic syndrome; Schizophrenia; Antipsychotics; Mitochondrial
   dysfunction
ID ELECTRON-TRANSPORT CHAIN; HUMAN SKELETAL-MUSCLE; GENE-EXPRESSION;
   INSULIN-RESISTANCE; POSSIBLE MECHANISM; ENERGY-METABOLISM; OXIDATIVE
   STRESS; COMPLEX-I; 2A GENE; CELLS
AB Metabolic syndrome (MetS) is seen more frequently in persons with schizophrenia than in the general population, and these metabolic abnormalities are further aggravated by second generation antipsychotic (SGA) drugs. Although the underlying mechanisms responsible for the increased prevalence of MetS among patients under SGA treatment are not well understood, alterations in mitochondria function have been implicated. We performed a comprehensive evaluation of the role of mitochondrial dysfunction in the pathophysiology of drug-induced MetS in schizophrenia. We found a downregulation in genes encoding subunits of the electron transport chain complexes (ETC), enzyme activity, and mitochondrial dynamics in peripheral blood cells from patients at high-risk for MetS. Additionally, we evaluated several markers of energy metabolism in lymphoblastoid cell lines from patients with schizophrenia and controls following exposure to antipsychotics. We found that the high-risk drugs clozapine and olanzapine induced a general down-regulation of genes involved in the ETC, as well as decreased activities of the corresponding enzymes, ATP levels and a significant decrease in all the functional parameters of mitochondrial oxygen consumption in cells from patients and controls. We also observed that the medium-risk SGA quetiapine decreased oxygen consumption and respiratory control ratio in controls and patients. Additionally, clozapine and olanzapine induced a downregulation of Drp1 and Mfn2 both in terms of mRNA and protein levels. Together, these data suggest that an intrinsic defect in multiple components of oxidative metabolism may contribute to the increased prevalence of MetS in patients under treatment with SGAs known to cause risk for MetS. (C) 2018 Elsevier B.V. and ECNP. All rights reserved.
C1 [Scaini, Giselli; Quevedo, Joao; Walss-Bass, Consuelo] Univ Texas Hlth Sci Ctr Houston UTHlth, McGovern Med Sch, Dept Psychiat & Behav Sci, Translat Psychiat Program, Houston, TX USA.
   [Quevedo, Joao; Walss-Bass, Consuelo] Univ Texas Hlth Sci Ctr Houston UTHlth, McGovern Med Sch, Dept Psychiat & Behav Sci, Ctr Excellence Mood Disorders, Houston, TX USA.
   [Quevedo, Joao] Univ Southern Santa Catarina UNESC, Hlth Sci Unit, Grad Program Hlth Sci, Translat Psychiat Lab, Criciuma, SC, Brazil.
   [Velligan, Dawn; Roberts, David L.] Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, San Antonio, TX 78229 USA.
   [Raventos, Henriette] Univ Costa Rica, Ctr Invest Biol Celular & Mol, San Jose, Costa Rica.
C3 University of Texas System; University of Texas Health Science Center
   Houston; Baylor College of Medicine; Baylor College Medical Hospital;
   University of Texas System; University of Texas Health Science Center
   Houston; Baylor College of Medicine; Baylor College Medical Hospital;
   Universidade do Sul de Santa Catarina; University of Texas System;
   University of Texas Health Science Center at San Antonio; Universidad
   Costa Rica
RP Walss-Bass, C (corresponding author), Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, 1941 East Rd,Ste 3110, Houston, TX 77054 USA.
EM Consuelo.WalssBass@uth.tmc.edu
RI Raventos, Henriette/GVS-4816-2022; Scaini, Giselli/AAX-4436-2020; de
   Quevedo, Joao Luciano/E-5491-2013; Walss-Bass, Consuelo/K-5702-2015;
   Scaini, Giselli/G-1378-2014
OI de Quevedo, Joao Luciano/0000-0003-3114-6611; Walss-Bass,
   Consuelo/0000-0003-2474-5448; Scaini, Giselli/0000-0002-9880-0887
FU University of Texas Health Science Center at San Antonio, Department of
   Psychiatry: Friends for Psychiatric Research; University of Texas Health
   Science Center at Houston, Department of Psychiatry and Behavioral
   Sciences
FX Funding for this study was provided in part by the University of Texas
   Health Science Center at San Antonio, Department of Psychiatry: Friends
   for Psychiatric Research, and University of Texas Health Science Center
   at Houston, Department of Psychiatry and Behavioral Sciences. The
   Department of Psychiatry: Friends for Psychiatric Research and
   Department of Psychiatry and Behavioral Sciences had no further role in
   study design; in the collection, analysis and interpretation of data; in
   the writing of the report; and in the decision to submit the paper for
   publication.
CR Abdel-Wahab B. A., 2014, CLOZAPINE INDUCED CA
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   [Anonymous], 2004, J CLIN PSYCHIAT, DOI DOI 10.4088/PCC.v06n0205
   Bach D, 2005, DIABETES, V54, P2685, DOI 10.2337/diabetes.54.9.2685
   Bach D, 2003, J BIOL CHEM, V278, P17190, DOI 10.1074/jbc.M212754200
   Baig MR, 2010, J PSYCHIATR PRACT, V16, P325, DOI 10.1097/01.pra.0000388627.36781.6a
   Basu R, 2004, BIPOLAR DISORD, V6, P314, DOI 10.1111/j.1399-5618.2004.00126.x
   Boke O, 2008, INT J PSYCHIAT MED, V38, P103, DOI 10.2190/PM.38.1.j
   Brand MD, 2011, BIOCHEM J, V435, P297, DOI 10.1042/BJ20110162
   BURKHARDT C, 1993, ANN NEUROL, V33, P512, DOI 10.1002/ana.410330516
   Casademont J, 2007, J CLIN PSYCHOPHARM, V27, P284, DOI 10.1097/JCP.0b013e318054753e
   Cassina A, 1996, ARCH BIOCHEM BIOPHYS, V328, P309, DOI 10.1006/abbi.1996.0178
   Cohn T, 2004, CAN J PSYCHIAT, V49, P753, DOI 10.1177/070674370404901106
   Contreras-Shannon V, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059012
   Davey GP, 1998, J BIOL CHEM, V273, P12753, DOI 10.1074/jbc.273.21.12753
   Fehsel K, 2005, J CLIN PSYCHOPHARM, V25, P419, DOI 10.1097/01.jcp.0000177668.42640.fe
   FISCHER JC, 1985, CLIN CHIM ACTA, V153, P23, DOI 10.1016/0009-8981(85)90135-4
   Gnaiger E, 2001, RESP PHYSIOL, V128, P277, DOI 10.1016/S0034-5687(01)00307-3
   Gnaiger E, 2009, INT J BIOCHEM CELL B, V41, P1837, DOI 10.1016/j.biocel.2009.03.013
   Hasnain M, 2010, CURR DIABETES REP, V10, P209, DOI 10.1007/s11892-010-0112-8
   Heiskanen T, 2003, J CLIN PSYCHIAT, V64, P575, DOI 10.4088/JCP.v64n0513
   Hroudova J, 2010, NEUROENDOCRINOL LETT, V31, P336
   Inczedy-Farkas G, 2012, BEHAV BRAIN FUNCT, V8, DOI 10.1186/1744-9081-8-9
   Ji BH, 2009, J PROTEOME RES, V8, P3633, DOI 10.1021/pr800876z
   Kelley DE, 2002, ANNU REV NUTR, V22, P325, DOI 10.1146/annurev.nutr.22.010402.102912
   Khalil RB, 2012, CLIN NEUROPHARMACOL, V35, P141, DOI 10.1097/WNF.0b013e31824d5288
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   McEvoy JP, 2005, SCHIZOPHR RES, V80, P19, DOI 10.1016/j.schres.2005.07.014
   Menga A, 2013, EUR NEUROPSYCHOPHARM, V23, P978, DOI 10.1016/j.euroneuro.2012.08.015
   Middleton FA, 2002, J NEUROSCI, V22, P2718, DOI 10.1523/JNEUROSCI.22-07-02718.2002
   Mingrone G, 2005, DIABETOLOGIA, V48, P2108, DOI 10.1007/s00125-005-1918-9
   Morris MA, 2008, J GEN VIROL, V89, P2806, DOI 10.1099/vir.0.2008/003970-0
   Newcomer JW, 2007, J CLIN PSYCHIAT, V68, P8
   Nie Q, 2014, MOL BIOL REP, V41, P6975, DOI 10.1007/s11033-014-3584-9
   Paredes RM, 2014, INT J NEUROPSYCHOPH, V17, P1139, DOI 10.1017/S1461145714000157
   Parone PA, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003257
   Pich S, 2005, HUM MOL GENET, V14, P1405, DOI 10.1093/hmg/ddi149
   Rollins B, 2010, AM J MED GENET B, V153B, P919, DOI 10.1002/ajmg.b.31062
   Rosenfeld M, 2011, BIOL PSYCHIAT, V69, P980, DOI 10.1016/j.biopsych.2011.01.010
   Rosmond R, 2002, OBES RES, V10, P1078, DOI 10.1038/oby.2002.146
   RUSTIN P, 1994, CLIN CHIM ACTA, V228, P35, DOI 10.1016/0009-8981(94)90055-8
   Schmidt AJ, 2010, J PSYCHOPHARMACOL, V24, P349, DOI 10.1177/0269881108096506
   Schmidt AJ, 2009, J PSYCHIATR RES, V43, P818, DOI 10.1016/j.jpsychires.2008.11.005
   Sebastián D, 2012, P NATL ACAD SCI USA, V109, P5523, DOI 10.1073/pnas.1108220109
   Srere P. A., 1969, Methods in Enzymology, V13, P3, DOI DOI 10.1016/0076-6879(69)13005-0
   Streck EL, 2007, N-S ARCH PHARMACOL, V376, P127, DOI 10.1007/s00210-007-0178-2
   Thomas EA, 2006, MOL NEUROBIOL, V34, P109, DOI 10.1385/MN:34:2:109
   Tschoner A, 2009, PHARMACOPSYCHIATRY, V42, P29, DOI 10.1055/s-0028-1100425
   Walss-Bass C, 2008, INT J NEUROPSYCHOPH, V11, P1097, DOI 10.1017/S1461145708008882
   Walss-Bass C, 2009, AM J MED GENET B, V150B, P219, DOI 10.1002/ajmg.b.30791
   Youle RJ, 2012, SCIENCE, V337, P1062, DOI 10.1126/science.1219855
   Zimber-Strobl U, 2001, SEMIN CANCER BIOL, V11, P423, DOI 10.1006/scbi.2001.0409
NR 52
TC 38
Z9 41
U1 1
U2 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0924-977X
EI 1873-7862
J9 EUR NEUROPSYCHOPHARM
JI Eur. Neuropsychopharmacol.
PD MAR
PY 2018
VL 28
IS 3
BP 369
EP 380
DI 10.1016/j.euroneuro.2018.01.004
PG 12
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA FX9KJ
UT WOS:000426417600004
PM 29449054
DA 2025-06-11
ER

PT J
AU Supriya, R
   Yu, AP
   Lee, PH
   Lai, CW
   Cheng, KK
   Yau, SY
   Chan, LW
   Yung, BY
   Siu, PM
AF Supriya, Rashmi
   Yu, Angus P.
   Lee, Paul H.
   Lai, Christopher W.
   Cheng, Kenneth K.
   Yau, Sonata Y.
   Chan, Lawrence W.
   Yung, Benjamin Y.
   Siu, Parco M.
TI Yoga training modulates adipokines in adults with high-normal blood
   pressure and metabolic syndrome
SO SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
LA English
DT Article
DE adipokine; high blood pressure; hypertension; metabolic syndrome;
   mind-body exercise
ID RANDOMIZED CONTROLLED-TRIAL; POSTMENOPAUSAL WOMEN; RISK-FACTORS;
   HYPERTENSION; EXERCISE; OBESITY; INTERVENTION; ADIPONECTIN; DISEASE;
   STRESS
AB Metabolic syndrome (MetS) is associated with diabetes mellitus and cardiovascular diseases. Our previous study indicated that people with MetS showed a decrease in waist circumference and a decreasing trend in blood pressure after 1-year yoga. This study investigated the effect of yoga on MetS people with high-normal blood pressure by exploring modulations in proinflammatory adipokines (leptin, chemerin, visfatin, and plasminogen activator inhibitor-1 or PAI-1) and an anti-inflammatory adipokine (adiponectin). A total of 97 Hong Kong Chinese individuals aged 57.6 +/- 9.1years with MetS and high-normal blood pressure were randomly assigned to control (n=45) and yoga groups (n=52). Participants in the control group were not given any intervention but were contacted monthly to monitor their health status. Participants in the yoga group underwent a yoga training program with three 1-hour yoga sessions weekly for 1year. The participants' sera were harvested and assessed for adipokines. Generalized estimating equation (GEE) was used to examine the interaction effect between 1-year time (pre vs post), and intervention (control vs yoga). GEE analyses revealed significant interaction effects between 1-year time and yoga intervention for the decreases in leptin and chemerin and the increase in adiponectin concentration in the sera examined. These results demonstrated that 1-year yoga training decreased proinflammatory adipokines and increased anti-inflammatory adipokine in adults with MetS and high-normal blood pressure. These findings support the beneficial role of yoga in managing MetS by favorably modulating adipokines.
C1 [Supriya, Rashmi; Lai, Christopher W.; Cheng, Kenneth K.; Chan, Lawrence W.; Yung, Benjamin Y.] Hong Kong Polytech Univ, Dept Hlth Technol & Informat, Fac Hlth & Social Sci, Kowloon, Hong Kong, Peoples R China.
   [Yu, Angus P.; Siu, Parco M.] Univ Hong Kong, Li Ka Shing Fac Med, Sch Publ Hlth, Pokfulam, Hong Kong, Peoples R China.
   [Lee, Paul H.] Hong Kong Polytech Univ, Sch Nursing, Fac Hlth & Social Sci, Kowloon, Hong Kong, Peoples R China.
   [Yau, Sonata Y.] Hong Kong Polytech Univ, Dept Rehabil Sci, Fac Hlth & Social Sci, Kowloon, Hong Kong, Peoples R China.
C3 Hong Kong Polytechnic University; University of Hong Kong; Hong Kong
   Polytechnic University; Hong Kong Polytechnic University
RP Siu, PM (corresponding author), Univ Hong Kong, Sch Publ Hlth, Pokfulam, Hong Kong, Peoples R China.
EM pmsiu@hku.hk
RI Cheng, Yip/C-4551-2009; Lai, Christopher Wai Keung/A-3852-2014; Lee,
   Paul/F-2549-2010
OI Yu, Angus, Pak Hung/0000-0002-7684-6198; Cheng, Kenneth King
   Yip/0000-0002-7274-0839; Supriya, Rashmi/0000-0003-2995-1910; Yau,
   Sonata Suk Yu/0000-0002-7425-6741; Lai, Christopher Wai
   Keung/0000-0002-8010-7232; Chan, Lawrence/0000-0001-6451-2273; Lee,
   Paul/0000-0002-5729-6450; Siu, Parco/0000-0002-3548-5058
FU Hong Kong Research Grants Council Hong Kong Ph.D. Fellowship Scheme
   [RTVX PF13-11753]; Hong Kong Polytechnic University Research Fund
   [1-ZE17]; University of Hong Kong Seed Fund for Basic Research
FX Hong Kong Research Grants Council Hong Kong Ph.D. Fellowship Scheme,
   Grant/Award Number: RTVX PF13-11753; Hong Kong Polytechnic University
   Research Fund, Grant/Award Number: 1-ZE17; The University of Hong Kong
   Seed Fund for Basic Research
CR Andersson U, 2004, J BIOL CHEM, V279, P12005, DOI 10.1074/jbc.C300557200
   Beltowski J, 2006, J HYPERTENS, V24, P789
   Black DS, 2013, PSYCHONEUROENDOCRINO, V38, P348, DOI 10.1016/j.psyneuen.2012.06.011
   Bower JE, 2014, PSYCHONEUROENDOCRINO, V43, P20, DOI 10.1016/j.psyneuen.2014.01.019
   Bozaoglu K, 2007, ENDOCRINOLOGY, V148, P4687, DOI 10.1210/en.2007-0175
   Chandra A, 2014, J AM COLL CARDIOL, V64, P997, DOI 10.1016/j.jacc.2014.05.057
   CHOBANIAN AV, 2003, JAMA-J AM MED ASSOC, V289, P2560, DOI DOI 10.1161/01.HYP.0000107251.49515.C2
   Davy KP, 2004, AM J PHYSIOL-REG I, V286, pR803, DOI 10.1152/ajpregu.00707.2003
   Fain JN, 2004, ENDOCRINOLOGY, V145, P2273, DOI 10.1210/en.2003-1336
   Fappa E, 2008, NUTRITION, V24, P286, DOI 10.1016/j.nut.2007.11.008
   Franklin Stanley S., 2006, Metabolic Syndrome and Related Disorders, V4, P287, DOI 10.1089/met.2006.4.287
   Friedenreich CM, 2011, ENDOCR-RELAT CANCER, V18, P357, DOI 10.1530/ERC-10-0303
   Fukuhara A, 2005, SCIENCE, V307, P426, DOI 10.1126/science.1097243
   Ganne Sudha, 2007, Expert Rev Cardiovasc Ther, V5, P201, DOI 10.1586/14779072.5.2.201
   Hagins M, 2014, J CLIN HYPERTENS, V16, P54, DOI 10.1111/jch.12244
   Hegde SV, 2013, COMPLEMENT THER MED, V21, P571, DOI 10.1016/j.ctim.2013.08.013
   Herder C, 2006, DIABETOLOGIA, V49, P921, DOI 10.1007/s00125-006-0190-y
   Innes KE, 2005, J AM BOARD FAM PRACT, V18, P491, DOI 10.3122/jabfm.18.6.491
   Kiecolt-Glaser JK, 2012, PHYSIOL BEHAV, V107, P809, DOI 10.1016/j.physbeh.2012.01.016
   Kiecolt-Glaser JK, 2010, PSYCHOSOM MED, V72, P113, DOI 10.1097/PSY.0b013e3181cb9377
   Lawrence T, 2009, CSH PERSPECT BIOL, V1, DOI 10.1101/cshperspect.a001651
   Lee JA, 2012, MENOPAUSE, V19, P296, DOI 10.1097/gme.0b013e31822d59a2
   Littman AJ, 2012, SUPPORT CARE CANCER, V20, P267, DOI 10.1007/s00520-010-1066-8
   López M, 2016, NAT REV ENDOCRINOL, V12, P421, DOI 10.1038/nrendo.2016.67
   Mancia G, 2003, J HYPERTENS, V21, P1011, DOI 10.1097/01.hjh.0000059051.65882.32
   Mayeux Richard, 2004, NeuroRx, V1, P182, DOI 10.1602/neurorx.1.2.182
   Mule G, 2006, Minerva Cardioangiol, V54, P173
   Mulè G, 2014, WORLD J CARDIOL, V6, P890, DOI 10.4330/wjc.v6.i9.890
   Pitsavos Christos, 2006, Review of Diabetic Studies, V3, P118, DOI 10.1900/RDS.2006.3.118
   Raghuraj P, 2008, APPL PSYCHOPHYS BIOF, V33, P65, DOI 10.1007/s10484-008-9055-0
   Siu PM, 2015, DIABETOL METAB SYNDR, V7, DOI 10.1186/s13098-015-0034-3
   Telles S, 2014, MED SCI MONITOR, V20, P894, DOI 10.12659/MSM.889805
   Visceglia E, 2011, J ALTERN COMPLEM MED, V17, P601, DOI 10.1089/acm.2010.0075
   Wahba IM, 2007, CLIN J AM SOC NEPHRO, V2, P550, DOI 10.2215/CJN.04071206
NR 34
TC 16
Z9 17
U1 0
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0905-7188
EI 1600-0838
J9 SCAND J MED SCI SPOR
JI Scand. J. Med. Sci. Sports
PD MAR
PY 2018
VL 28
IS 3
BP 1130
EP 1138
DI 10.1111/sms.13029
PG 9
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA FY0VA
UT WOS:000426529300039
PM 29205515
DA 2025-06-11
ER

PT J
AU Aksu, O
   Aydin, B
   Doguç, DK
   Ilhan, I
   Ozturk, O
   Altuntas, A
   Demirkan, H
   Koroglu, BK
   Tamer, MN
AF Aksu, O.
   Aydin, B.
   Doguc, D. K.
   Ilhan, I.
   Ozturk, O.
   Altuntas, A.
   Demirkan, H.
   Koroglu, B. K.
   Tamer, M. N.
TI The evaluation of Nesfatin-1 levels in patients with OSAS associated
   with metabolic syndrome
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE Obstructive sleep apnea syndrome; Metabolic syndrome; Nesfatin-1
ID OBSTRUCTIVE SLEEP-APNEA
AB Purpose The association of obstructive sleep apnea syndrome (OSAS) and metabolic syndrome (MS) has been demonstrated in studies and in recent years; the effect of OSAS on insulin resistance independent of the level of obesity is being investigated. Nesfatin-1 is a newly defined 82 amino acid protein with a precursor molecule of NUCB2 (nucleobindin 2). Nesfatin-1 is not only essential in regulation of food ingestion but also important in regulation of some brain functions, autonomic regulation, stress, mental state, and paradoxical sleep. We aimed to evaluate the relationship between OSAS and MS and the MS dependent or independent effect of Nesfatin-1 on this relationship.
   Methods Patients admitted with clinical signs of OSAS are included. Patients are divided into three groups based on Apnea-Hypopnea Index (AHI) on Polysomnography (PSG) as mild, moderate, and severe OSAS. A total of 59 patients were included the control patients. Several OSAS parameters and laboratory findings which are and are not MS dependent are compared. Nesfatin-1 levels are evaluated in all OSAS patients with and without MS.
   Results There were significantly more males in all groups (p = 0.007). There was no significant difference between groups in terms of Nesfatin-1 levels. Nesfatin-1 levels were significantly lower in MS group compared to non-MS group (p = 0.021).
   Conclusion Nesfatin-1 which is known to play a role in the pathophysiology of insulin resistance can be a beneficial target in developing new therapeutic targets for treatment of patients with obesity without any toxic effects in the future.
C1 [Aksu, O.; Aydin, B.; Demirkan, H.; Koroglu, B. K.; Tamer, M. N.] Suleyman Demirel Univ, Sch Med, Div Endocrinol & Metab, Dept Internal Med,Fac Med, TR-3200 Isparta, Turkey.
   [Doguc, D. K.; Ilhan, I.] Suleyman Demirel Univ, Dept Biochem, Fac Med, TR-3200 Isparta, Turkey.
   [Ozturk, O.] Suleyman Demirel Univ, Dept Chest Dis, Fac Med, TR-3200 Isparta, Turkey.
   [Altuntas, A.] Suleyman Demirel Univ, Div Nephrol, Dept Internal Med, Fac Med, TR-3200 Isparta, Turkey.
C3 Suleyman Demirel University; Suleyman Demirel University; Suleyman
   Demirel University; Suleyman Demirel University
RP Aksu, O (corresponding author), Suleyman Demirel Univ, Sch Med, Div Endocrinol & Metab, Dept Internal Med,Fac Med, TR-3200 Isparta, Turkey.
EM droaksu@yahoo.com
RI Aksu, Oguzhan/MAH-8332-2025; ÖZTÜRK, ÖNDER/A-7651-2016; ilhan,
   ilter/AAA-4662-2021; Aydın, Betül/HDM-9418-2022
OI Ilhan, Ilter/0000-0003-3739-9580; Aksu, Oguzhan/0000-0003-4666-7129
CR Abaci A, 2013, PEDIATR DIABETES, V14, P189, DOI 10.1111/pedi.12009
   [Anonymous], ICSD2 AM AC SLEEP ME
   [Anonymous], EUR RESP MONOGRAPH
   Bez Y, 2010, KLIN PSIKOFARMAKOL B, V20, P288, DOI 10.1080/10177833.2010.11790674
   Bonnet MS, 2009, J NEUROINFLAMM, V6, DOI 10.1186/1742-2094-6-27
   Cui HX, 2012, J COMP NEUROL, V520, P4168, DOI 10.1002/cne.23145
   Fletcher EC, 2000, SLEEP, V23, pS127
   Fulop T, 2006, PATHOL BIOL, V54, P375, DOI 10.1016/j.patbio.2006.07.002
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Ip MSM, 2002, AM J RESP CRIT CARE, V165, P670, DOI 10.1164/ajrccm.165.5.2103001
   Jego S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0052525
   Lindholm J, 2014, PITUITARY, V17, P374, DOI 10.1007/s11102-013-0509-x
   Oh-I S, 2006, NATURE, V443, P709, DOI 10.1038/nature05162
   OLSON LG, 1995, AM J RESP CRIT CARE, V152, P711, DOI 10.1164/ajrccm.152.2.7633731
   Patil SP, 2007, CHEST, V132, P325, DOI 10.1378/chest.07-0040
   Schwab R J., 1998, Fishman's Pulmonary Diseases and Disorders, P1617
   Shen P, 2015, SLEEP BREATH, V19, P515, DOI 10.1007/s11325-014-1039-0
   Shimizu H, 2009, ENDOCRINOLOGY, V150, P662, DOI 10.1210/en.2008-0598
   Soylu AC, 2012, SLEEP BREATH, V16, P1151, DOI 10.1007/s11325-011-0623-9
   Su YJ, 2010, BIOCHEM BIOPH RES CO, V391, P1039, DOI 10.1016/j.bbrc.2009.12.014
   Tang CH, 2012, PEPTIDES, V36, P39, DOI 10.1016/j.peptides.2012.04.014
   Tiengo A, 2008, DIABETES METAB, V34, P447, DOI 10.1016/j.diabet.2008.08.001
   Tuomilehto H, 2013, SLEEP MED REV, V17, P321, DOI 10.1016/j.smrv.2012.08.002
   Vas S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059809
   Xu E, 2014, REV ENDOCR METAB DIS, V15, P79, DOI 10.1007/s11154-013-9282-4
   Yilmaz M, 2005, LARYNGOSCOPE, V115, P832, DOI 10.1097/01.MLG.0000157334.88700.E6
NR 26
TC 21
Z9 22
U1 0
U2 17
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0391-4097
EI 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD APR
PY 2015
VL 38
IS 4
BP 463
EP 469
DI 10.1007/s40618-014-0216-0
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CE3CQ
UT WOS:000351702500011
PM 25432328
DA 2025-06-11
ER

PT J
AU Lee, J
   Choi, YS
   Jeong, YJ
   Lee, J
   Kim, JH
   Kim, SH
   Joe, SH
   Jeon, TH
AF Lee, Junyong
   Choi, Youn Seon
   Jeong, Young Jin
   Lee, Juneyoung
   Kim, Jung Hyun
   Kim, Su Hyun
   Joe, Sook-Haeng
   Jeon, Tae Hee
TI Poor-Quality Sleep Is Associated with Metabolic Syndrome in Korean
   Adults
SO TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
LA English
DT Article
DE adiposity; insulin-resistance; Korea; metabolic syndrome; sleep
ID RISK-FACTOR; INSULIN-RESISTANCE; NATIONAL-HEALTH; DURATION; PREVALENCE;
   DISEASE; STRESS; INDEX; MEN
AB Sleep disorder and metabolic syndrome (MetS) are important health-related problems. Recently, sleep duration has decreased among Korean adults. In this study, we examined whether sleep quality is associated with MetS by analyzing 301 subjects, aged 20 years or over, without acute and severe illness who visited three primary care clinics. Sleep duration, sleep quality and the risk of sleep-related breathing disorder (SRBD) were assessed with a standardized sleeping-estimating instrument. MetS was defined according to the modified diagnostic criteria of the National Cholesterol Education Program Adult Treatment Panel-III using the Korean abdominal obesity definition. In the multiple logistic regression analysis, compared with the 7-hour sleep group, the adjusted odds ratios (ORs) of the <= 5- and >= 9-hour sleep groups for MetS were 4.89 and 5.98, respectively. Compared with the good-sleep quality and low-SRBD risk groups, the adjusted ORs of the poor-quality sleep and high-SRBD risk groups were 3.83 and 1.92, respectively (p < 0.05). In the <= 5- and >= 9-hour sleep groups, the prevalence of elevated triglyceride and high HOMA-IR was higher (p = 0.069). In the poor-quality sleep group, the prevalence of abdominal obesity, elevated triglyceride, low HDL cholesterol, high fasting insulin and high HOMA-IR were higher. In the high-SRBD risk group, the prevalence of abdominal obesity, obesity and elevated triglyceride were higher (p < 0.05). Overall, the <= 5- or >= 9-hour sleep duration, poor-quality sleep and high-SRBD risk are related with the high prevalence of MetS, perhaps through elevated insulin-resistance resulting from adiposity.
C1 [Lee, Junyong; Jeong, Young Jin; Jeon, Tae Hee] Vet Hlth Serv VHS Med Ctr, Dept Family Med, Seoul, South Korea.
   [Choi, Youn Seon; Kim, Su Hyun] Korea Univ, Guro Hosp, Coll Med, Dept Family Med, Seoul 152703, South Korea.
   [Lee, Juneyoung] Korea Univ, Coll Med, Dept Biostat, Seoul 152703, South Korea.
   [Kim, Jung Hyun] Hana Gen Hosp, Dept Family Med, Cheongju, Chungcheongbuk, South Korea.
   [Joe, Sook-Haeng] Korea Univ, Guro Hosp, Coll Med, Dept Psychiat, Seoul 152703, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine); Korea
   University; Korea University Medicine (KU Medicine); Korea University;
   Korea University Medicine (KU Medicine)
RP Choi, YS (corresponding author), Korea Univ, Guro Hosp, Coll Med, Dept Family Med, 97 Guro Dong Gil, Seoul 152703, South Korea.
EM younseon@korea.ac.kr
RI Lee, Jeong-Hoon/Q-1055-2018; Kim, Sin Gon/KQU-7757-2024
OI Lee, Juneyoung/0000-0001-8073-9304; Choi, Youn Seon/0000-0003-2406-5848;
   Lee, Junyong/0000-0001-9467-9277
CR [Anonymous], 3 KOR NAT HLTH NUTR
   [Anonymous], 2000, ASIA PACIFIC PERSPEC
   Ayas NT, 2003, ARCH INTERN MED, V163, P205, DOI 10.1001/archinte.163.2.205
   Bae JM, 1992, J Korean Acad Fam Med, V13, P809
   Björntorp P, 2000, BRIT J NUTR, V83, pS49, DOI 10.1017/S0007114500000957
   Bjorvatn B, 2007, J SLEEP RES, V16, P66, DOI 10.1111/j.1365-2869.2007.00569.x
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1016/0165-1781(89)90047-4
   Cho M.J., 1993, Journal of Korean Neuropsychiatric Association, V32, P381
   Choi KM, 2008, INT J OBESITY, V32, P1091, DOI 10.1038/ijo.2008.62
   Dolberg OT, 1998, AM J PSYCHIAT, V155, P1119, DOI 10.1176/ajp.155.8.1119
   이석민, 2006, 에너지공학, V15, P1
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   FRANK SH, 1988, J FAM PRACTICE, V26, P533
   Gangwisch JE, 2006, HYPERTENSION, V47, P833, DOI 10.1161/01.HYP.0000217362.34748.e0
   Gangwisch JE, 2005, SLEEP, V28, P1289, DOI 10.1093/sleep/28.10.1289
   Golden SH, 2002, DIABETES, V51, P3069, DOI 10.2337/diabetes.51.10.3069
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Heslop Pauline, 2002, Sleep Med, V3, P305, DOI 10.1016/S1389-9457(02)00016-3
   Jennings JR, 2007, SLEEP, V30, P219, DOI 10.1093/sleep/30.2.219
   Kim G.D., 1998, THESIS KYUNGPOOK NAT
   Kim J, 2004, AM J RESP CRIT CARE, V170, P1108, DOI 10.1164/rccm.200404-519OC
   Kim S., 1996, Journal of the Korean Academy of Family Medicine, V17, P42
   Klein BEK, 2002, DIABETES CARE, V25, P1790, DOI 10.2337/diacare.25.10.1790
   Knutson KL, 2006, ARCH INTERN MED, V166, P1768, DOI 10.1001/archinte.166.16.1768
   Lee Y.-M., 2002, THE J, V11, P123
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Meigs JB, 2002, AM J MANAG CARE, V8, pS283
   Narkiewicz K, 1998, CIRCULATION, V97, P943
   Park H.S., 2000, J KOREAN ACAD PSYCHI, V9, P429
   Peppard PE, 2000, JAMA-J AM MED ASSOC, V284, P3015, DOI 10.1001/jama.284.23.3015
   Phillips BG, 1999, J HYPERTENS, V17, P1297, DOI 10.1097/00004872-199917090-00009
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Rosmond R, 2005, PSYCHONEUROENDOCRINO, V30, P1, DOI 10.1016/j.psyneuen.2004.05.007
   Sasanabe R, 2006, HYPERTENS RES, V29, P315, DOI 10.1291/hypres.29.315
   Shin S. C., 1991, Journal of Korean Neuropsychiatric Association, V30, P752
   Spiegel K, 2005, J APPL PHYSIOL, V99, P2008, DOI 10.1152/japplphysiol.00660.2005
   Spiegel K, 2004, ANN INTERN MED, V141, P846, DOI 10.7326/0003-4819-141-11-200412070-00008
   Taheri S, 2004, PLOS MED, V1, P210, DOI 10.1371/journal.pmed.0010062
   Vorona RD, 2005, ARCH INTERN MED, V165, P25, DOI 10.1001/archinte.165.1.25
NR 40
TC 24
Z9 26
U1 0
U2 6
PU TOHOKU UNIV MEDICAL PRESS
PI SENDAI
PA 2-1, SEIRYO-MACHI, AOBA-KU, SENDAI, MIYAGI 980-8575, JAPAN
SN 0040-8727
EI 1349-3329
J9 TOHOKU J EXP MED
JI Tohoku J. Exp. Med.
PD DEC
PY 2013
VL 231
IS 4
BP 281
EP 291
DI 10.1620/tjem.231.281
PG 11
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 292FB
UT WOS:000329886500006
PM 24305464
OA Bronze
DA 2025-06-11
ER

PT J
AU Zong, G
   Demark-Wahnefried, W
   Wu, HY
   Lin, X
AF Zong, Geng
   Demark-Wahnefried, Wendy
   Wu, Hongyu
   Lin, Xu
TI Effects of flaxseed supplementation on erythrocyte fatty acids and
   multiple cardiometabolic biomarkers among Chinese with risk factors of
   metabolic syndrome
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Flaxseed; PUFA; Cytokines; Metabolic syndrome
ID ALPHA-LINOLENIC-ACID; CARDIOVASCULAR-DISEASE; DOUBLE-BLIND; MARKERS
AB We investigated effects of ground whole flaxseed supplementation on erythrocyte polyunsaturated fatty acids (PUFAs) and serum biomarkers of inflammation, endothelial dysfunction, oxidative stress, and thrombosis in Chinese with risk factors of metabolic syndrome (MetS).
   This study was a secondary analysis of a 12-week, randomized, parallel-group trial in participants screened for MetS. The analysis included only those with 2 or more components of MetS before receiving either lifestyle counseling (LC, n = 90) or LC + 30 g/day flaxseed supplementation (LCF, n = 83).
   Compared to the LC group, those in the LCF group experienced significant increases in total erythrocyte n-3 PUFAs, alpha-linolenic acid, eicosapentenoic acid, and docosapentenoic acid (all P < 0.001), while total n-6 PUFAs (P < 0.05) and n-6/n-3 ratio decreased (P < 0.001). Arachidonic acid increased significantly in the LC group (P < 0.001), and serum high-sensitivity C-reactive protein, interleukin-18, soluble intracellular adhesion molecular-1, E-selectin, and plasminogen activator inhibitor-1 declined significantly in both groups (all P < 0.05), but no between-group differences were observed. There was no significant change in serum interleukin-6, tumor necrosis factor-alpha, soluble vascular adhesion molecular-1, monocyte chemoattractant protein-1, and oxidized low-density lipoprotein in either group.
   These data suggest that flaxseed supplementation increases erythrocyte n-3 PUFAs, decreases n-6 PUFAs and n-6/n-3 ratio in participants with risk factors of MetS, but has no additional benefits beyond the lifestyle consulting for the multiple biomarkers tested in the current study.
C1 [Zong, Geng; Lin, Xu] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai 200031, Peoples R China.
   [Zong, Geng; Lin, Xu] Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China.
   [Demark-Wahnefried, Wendy] Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35294 USA.
   [Wu, Hongyu] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
C3 Chinese Academy of Sciences; Chinese Academy of Sciences; University of
   Alabama System; University of Alabama Birmingham; Harvard University;
   Harvard T.H. Chan School of Public Health
RP Lin, X (corresponding author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, 294 Tai Yuan Rd, Shanghai 200031, Peoples R China.
EM xlin@sibs.ac.cn
RI lin, xu/KOC-3517-2024; Zong, Geng/ABG-6946-2021
OI Demark-Wahnefried, Wendy/0000-0001-5241-932X
FU National Natural Science Foundation of China [30930081, 81021002];
   Ministry of Science and Technology of China [2011CB504002]; Chinese
   Academy of Sciences [KSCX2-EW-R-10]
FX This study was supported by the National Natural Science Foundation of
   China (30930081 and 81021002), the Ministry of Science and Technology of
   China (2011CB504002) and the Chinese Academy of Sciences
   (KSCX2-EW-R-10). The authors' responsibilities were as follows: H. W.
   and X. L. were involved in the study design; G.Z. and H. W. were in
   charge of participant management; G.Z., H. W, and X. L. took part in the
   data collection; G.Z completed the data analysis and drafted the initial
   manuscript, with help from H. W. W. D-W and X. L for interpretation of
   the findings. All authors were responsible for critical revisions and
   final approval of the manuscript. All authors declared no conflict of
   interest.
CR Austria JA, 2008, J AM COLL NUTR, V27, P214, DOI 10.1080/07315724.2008.10719693
   Bloedon LT, 2008, J AM COLL NUTR, V27, P65, DOI 10.1080/07315724.2008.10719676
   Brenna JT, 2009, PROSTAG LEUKOTR ESS, V80, P85, DOI 10.1016/j.plefa.2009.01.004
   Burdge GC, 2005, REPROD NUTR DEV, V45, P581, DOI 10.1051/rnd:2005047
   Dodin S, 2008, NUTRITION, V24, P23, DOI 10.1016/j.nut.2007.09.003
   Faintuch J, 2007, OBES SURG, V17, P341, DOI 10.1007/s11695-007-9062-x
   Finnegan YE, 2003, J NUTR, V133, P2210, DOI 10.1093/jn/133.7.2210
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Koh KK, 2005, J AM COLL CARDIOL, V46, P1978, DOI 10.1016/j.jacc.2005.06.082
   Portolesi R, 2007, J LIPID RES, V48, P1592, DOI 10.1194/jlr.M700081-JLR200
   Prasad K, 2009, J CARDIOVASC PHARM, V54, P369, DOI 10.1097/FJC.0b013e3181af04e5
   Simopoulos AP, 2008, EXP BIOL MED, V233, P674, DOI 10.3181/0711-MR-311
   Taylor CG, 2010, J AM COLL NUTR, V29, P72, DOI 10.1080/07315724.2010.10719819
   Wu HY, 2010, J NUTR, V140, P1937, DOI 10.3945/jn.110.126300
   Zhao GX, 2004, J NUTR, V134, P2991, DOI 10.1093/jn/134.11.2991
NR 15
TC 16
Z9 16
U1 0
U2 13
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD AUG
PY 2013
VL 52
IS 5
BP 1547
EP 1551
DI 10.1007/s00394-012-0461-y
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 185YQ
UT WOS:000322008000015
PM 23179200
DA 2025-06-11
ER

PT J
AU Libby, P
   Plutzky, J
AF Libby, Peter
   Plutzky, Jorge
TI Inflammation in diabetes mellitus:: Role of peroxisome
   proliferator-activated receptor-α and peroxisome proliferator-activated
   receptor-γ agonists
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Review
ID CORONARY-HEART-DISEASE; TISSUE FACTOR EXPRESSION; APOLIPOPROTEIN-A-I;
   NF-KAPPA-B; PPAR-ALPHA; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   GENE-EXPRESSION; COMBINED HYPERLIPIDEMIA; ROSIGLITAZONE TREATMENT
AB Patients with type 2 diabetes mellitus and/or the metabolic syndrome have considerable cardiovascular risk. Treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) and with antihypertensive and some antihyperglycemic agents reduces this risk, but residual macrovascular morbidity and mortality persist, even in patients assigned to intensive multifactorial intervention programs. Therapeutic strategies that target inflammation and lipid abnormalities not well addressed by statins may offer additional opportunities for improving the prognosis of these patients. Inflammation, a key mechanism of atherogenesis, appears to have particular relevance to diabetic vascular complications, as well as in the development of diabetes itself. Oxidative stress and hyperglycemia also figure among the pathogenic factors that promote cardiovascular complications in patients with the metabolic syndrome and/or diabetes and may augment the ongoing inflammation. Peroxisome proliferator-activated receptor (PPAR)-alpha and PPAR-gamma, members of the nuclear receptor family, form ligand-activated transcription factors that regulate key important metabolic pathways. PPARs have become therapeutic targets through the use of the fibrate class of antidyslipidemic drugs (PPAR-alpha) and the insulin-sensitizing thiazolidinediones (PPAR-gamma). The activation of these PPARs may also suppress inflammation and atherosclerosis. Recent clinical trials (Fenofibrate Intervention and Event Lowering in Diabetes [FIELD], Prospective Pioglitazone Clinical Trial in Macrovascular Events [PROactive]) have considered the impact of these PPAR agonists on cardiovascular disease, with mixed effects that require careful analysis, especially given ongoing trials and additional PPAR agonists in development. (c) 2007 Elsevier Inc. All rights reserved.
C1 Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Cardiovasc Med,Dept Med, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School
RP Libby, P (corresponding author), Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Cardiovasc Med,Dept Med, 77 Ave Louis Pasteur, Boston, MA 02115 USA.
EM plibby@rics.bwh.harvard.edu
RI Libby, Peter/AAY-6404-2021; Plutzky, Jorge/V-3410-2019
CR Agarwal R, 2006, AM J PHYSIOL-RENAL, V290, pF600, DOI 10.1152/ajprenal.00289.2005
   Aljada A, 2001, J CLIN ENDOCR METAB, V86, P3250, DOI 10.1210/jc.86.7.3250
   AMENTO EP, 1991, ARTERIOSCLER THROMB, V11, P1223, DOI 10.1161/01.ATV.11.5.1223
   [Anonymous], 2002, JAMA, V288, P2998, DOI DOI 10.1016/S1062-1458(03)00049-7
   [Anonymous], DIABETES CARE S
   Athyros VG, 2005, DIABETES OBES METAB, V7, P397, DOI 10.1111/j.1463-1326.2004.00409.x
   Athyros VG, 2002, DIABETES CARE, V25, P1198, DOI 10.2337/diacare.25.7.1198
   Austin MA, 1998, AM J CARDIOL, V81, p7B, DOI 10.1016/S0002-9149(98)00031-9
   Balkau B, 1999, DIABETIC MED, V16, P442
   Baynes JW, 1999, DIABETES, V48, P1, DOI 10.2337/diabetes.48.1.1
   Berger J, 2002, ANNU REV MED, V53, P409, DOI 10.1146/annurev.med.53.082901.104018
   Berthou L, 1996, J CLIN INVEST, V97, P2408, DOI 10.1172/JCI118687
   Betteridge DJ, 2005, DIABETOLOGIA, V48, P2477, DOI 10.1007/s00125-005-0034-1
   CASTELLI WP, 1986, JAMA-J AM MED ASSOC, V256, P2835, DOI 10.1001/jama.256.20.2835
   CHAIT A, 1993, AM J MED, V94, P350, DOI 10.1016/0002-9343(93)90144-E
   Chang JT, 2004, PHARMACOEPIDEM DR S, V13, P417, DOI 10.1002/pds.977
   Chinetti G, 1998, J BIOL CHEM, V273, P25573, DOI 10.1074/jbc.273.40.25573
   Choi D, 2004, DIABETES CARE, V27, P2654, DOI 10.2337/diacare.27.11.2654
   Chu CS, 2006, AM J CARDIOL, V97, P646, DOI 10.1016/j.amjcard.2005.09.101
   Colhoun HM, 2004, LANCET, V364, P685, DOI 10.1016/S0140-6736(04)16895-5
   Collins R, 2003, LANCET, V361, P2005
   Collins T, 2001, J CLIN INVEST, V107, P255, DOI 10.1172/JCI10373
   Davidson MH, 2006, EXPERT OPIN DRUG SAF, V5, P145, DOI 10.1517/14740338.5.1.145
   de Dios ST, 2003, CIRCULATION, V107, P2548, DOI 10.1161/01.CIR.0000074040.31731.96
   Delerive P, 1999, CIRC RES, V85, P394, DOI 10.1161/01.RES.85.5.394
   Delerive P, 1999, J BIOL CHEM, V274, P32048, DOI 10.1074/jbc.274.45.32048
   Delerive P, 2001, J ENDOCRINOL, V169, P453, DOI 10.1677/joe.0.1690453
   Derosa G, 2004, CLIN THER, V26, P1599, DOI 10.1016/j.clinthera.2004.10.008
   Després JP, 2003, ARTERIOSCL THROM VAS, V23, P702, DOI 10.1161/01.ATV.0000062990.62034.64
   Dormandy JA, 2005, LANCET, V366, P1279, DOI 10.1016/S0140-6736(05)67528-9
   Duez H, 2002, J BIOL CHEM, V277, P48051, DOI 10.1074/jbc.M206966200
   Durrington PN, 2004, DIABETES RES CLIN PR, V64, P137, DOI 10.1016/j.diabres.2003.11.012
   Ellen RLB, 1998, AM J CARDIOL, V81, p60B, DOI 10.1016/S0002-9149(98)00040-X
   Empen K, 2003, CARDIOVASC DIABETOL, V2, DOI 10.1186/1475-2840-2-17
   Farnier M, 2000, AM J CARDIOL, V85, P53, DOI 10.1016/S0002-9149(99)00606-2
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   Frick MH, 1997, CIRCULATION, V96, P2137
   FRICK MH, 1987, NEW ENGL J MED, V317, P1237, DOI 10.1056/NEJM198711123172001
   Frost RJA, 2001, AM J CARDIOL, V87, P44, DOI 10.1016/S0002-9149(00)01270-4
   Gaede P, 2003, NEW ENGL J MED, V348, P383, DOI 10.1056/NEJMoa021778
   Gerber P, 2003, CURR MED RES OPIN, V19, P532, DOI 10.1185/030079903125002180
   Gervois P, 2004, J BIOL CHEM, V279, P16154, DOI 10.1074/jbc.M400346200
   Glass CK, 2006, J CLIN INVEST, V116, P556, DOI 10.1172/JCI27913
   Goldberg RB, 2005, DIABETES CARE, V28, P1547, DOI 10.2337/diacare.28.7.1547
   Goldberg RB, 1998, CIRCULATION, V98, P2513, DOI 10.1161/01.CIR.98.23.2513
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Grundy SM, 2005, AM J CARDIOL, V95, P462, DOI 10.1016/j.amjcard.2004.10.012
   Haffner SM, 2002, CIRCULATION, V106, P679, DOI 10.1161/01.CIR.0000025403.20953.23
   Han CY, 2006, ARTERIOSCL THROM VAS, V26, P1806, DOI 10.1161/01.ATV.0000227472.70734.ad
   Hansson GK, 2005, NEW ENGL J MED, V352, P1685, DOI 10.1056/NEJMra043430
   Hansson L, 1998, LANCET, V351, P1755, DOI 10.1016/S0140-6736(98)04311-6
   HELLER F, 1983, EUR J CLIN PHARMACOL, V25, P57, DOI 10.1007/BF00544015
   Henke BR, 2004, J MED CHEM, V47, P4118, DOI 10.1021/jm030631e
   Hennuyer N, 2005, ARTERIOSCL THROM VAS, V25, P1897, DOI 10.1161/01.ATV.0000175756.56818.ee
   Home PD, 2005, DIABETOLOGIA, V48, P1726, DOI 10.1007/s00125-005-1869-1
   Inoue I, 2002, BIOCHEM BIOPH RES CO, V290, P131, DOI 10.1006/bbrc.2001.6141
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jiang CY, 1998, NATURE, V391, P82, DOI 10.1038/34184
   Jones PH, 2005, AM J CARDIOL, V95, P120, DOI 10.1016/j.amjcard.2004.08.076
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   Keech A, 2005, LANCET, V366, P1849, DOI 10.1016/S0140-6736(05)67667-2
   Kendall DM, 2006, DIABETES CARE, V29, P1016, DOI 10.2337/dc05-1146
   Koh KK, 2004, ATHEROSCLEROSIS, V174, P379, DOI 10.1016/j.atherosclerosis.2004.01.033
   Koh KK, 2005, DIABETES CARE, V28, P1419, DOI 10.2337/diacare.28.6.1419
   KOSKINEN P, 1992, DIABETES CARE, V15, P820, DOI 10.2337/diacare.15.7.820
   Kowalski J, 2003, EUR J CLIN PHARMACOL, V59, P189, DOI 10.1007/s00228-003-0581-7
   Langenfeld MR, 2005, CIRCULATION, V111, P2525, DOI 10.1161/01.CIR.0000165072.01672.21
   Law RE, 2000, CIRCULATION, V101, P1311, DOI 10.1161/01.CIR.101.11.1311
   Lawrence JM, 2004, DIABETES CARE, V27, P41, DOI 10.2337/diacare.27.1.41
   Li AC, 2000, J CLIN INVEST, V106, P523, DOI 10.1172/JCI10370
   Li AC, 2004, J CLIN INVEST, V114, P1564, DOI 10.1172/JCI200418730
   Libby P, 2006, AM J CLIN NUTR, V83, p456S
   Libby P, 2002, CIRCULATION, V106, P2760, DOI 10.1161/01.CIR.0000037282.92395.AE
   Libby P, 2002, NATURE, V420, P868, DOI 10.1161/ATVBAHA.108.179705
   *LONG TERM INT PRA, 1998, NEW ENGL J MED, V339, P134
   Luster AD, 1998, NEW ENGL J MED, V338, P436, DOI 10.1056/NEJM199802123380706
   Madej A, 1998, INT J CLIN PHARM TH, V36, P345
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   MALMENDIER CL, 1985, ATHEROSCLEROSIS, V55, P161, DOI 10.1016/0021-9150(85)90095-4
   Marchesi S, 2003, J CLIN PHARM THER, V28, P419, DOI 10.1046/j.0269-4727.2003.00512.x
   Marfella R, 2006, DIABETES, V55, P622, DOI 10.2337/diabetes.55.03.06.db05-0832
   Martin G, 1997, J BIOL CHEM, V272, P28210, DOI 10.1074/jbc.272.45.28210
   Marx N, 1999, CIRCULATION, V99, P3125, DOI 10.1161/01.CIR.99.24.3125
   Marx N, 2004, CIRC RES, V94, P1168, DOI 10.1161/01.RES.0000127122.22685.0A
   Marx N, 2003, CIRCULATION, V107, P1954, DOI 10.1161/01.CIR.0000069272.06194.91
   Marx N, 1998, CIRC RES, V83, P1097, DOI 10.1161/01.RES.83.11.1097
   Marx N, 1998, AM J PATHOL, V153, P17, DOI 10.1016/S0002-9440(10)65540-X
   Marx N, 2001, CIRCULATION, V103, P213
   Marx N, 2000, J IMMUNOL, V164, P6503, DOI 10.4049/jimmunol.164.12.6503
   März W, 2004, CIRCULATION, V110, P3068, DOI 10.1161/01.CIR.0000146898.06923.80
   Mehta JL, 2003, ARTERIOSCL THROM VAS, V23, P2203, DOI 10.1161/01.ATV.0000094411.98127.5F
   Mohanty P, 2004, J CLIN ENDOCR METAB, V89, P2728, DOI 10.1210/jc.2003-032103
   Mukhtar R, 2005, DIABETIC MED, V22, P6, DOI 10.1111/j.1466-5468.2005.01711c.x
   Nesto RW, 2003, CIRCULATION, V108, P2941, DOI 10.1161/01.CIR.0000103683.99399.7E
   Neve BP, 2001, CIRCULATION, V103, P207
   Ninomiya JK, 2004, CIRCULATION, V109, P42, DOI 10.1161/01.CIR.0000108926.04022.0C
   Nishio K, 2006, DIABETES CARE, V29, P101, DOI 10.2337/diacare.29.1.101
   Nissen SE, 2005, JAMA-J AM MED ASSOC, V294, P2581, DOI 10.1001/JAMA.294.20.JOC50147
   Ogata T, 2004, J AM COLL CARDIOL, V43, P1481, DOI 10.1016/j.jacc.2003.11.043
   Okopien B, 2005, J CARDIOVASC PHARM, V46, P377, DOI 10.1097/01.fjc.0000175455.46245.c8
   Okopien B, 2004, ATHEROSCLEROSIS, V176, P327, DOI 10.1016/j.atherosclerosis.2004.05.009
   Osman A, 2004, AM HEART J, V147, DOI 10.1016/j.ahj.2003.12.006
   Parhofer KG, 2005, EXP CLIN ENDOCR DIAB, V113, P49, DOI 10.1055/s-2004-830527
   Pasceri V, 2000, CIRCULATION, V101, P235, DOI 10.1161/01.CIR.101.3.235
   Pennathur S, 2004, FRONT BIOSCI-LANDMRK, V9, P565, DOI 10.2741/1257
   Pradhan AD, 2002, EUR HEART J, V23, P831, DOI 10.1053/euhj.2001.3052
   Prueksaritanont T, 2002, DRUG METAB DISPOS, V30, P1280, DOI 10.1124/dmd.30.11.1280
   Pyorala K, 1997, DIABETES CARE, V20, P614, DOI 10.2337/diacare.20.4.614
   Reaven G, 2005, CIRCULATION, V112, P3030, DOI 10.1161/CIRCULATIONAHA.105.504670
   Ricote M, 1998, P NATL ACAD SCI USA, V95, P7614, DOI 10.1073/pnas.95.13.7614
   Ricote M, 1998, NATURE, V391, P79, DOI 10.1038/34178
   Robins SJ, 2001, JAMA-J AM MED ASSOC, V285, P1585, DOI 10.1001/jama.285.12.1585
   Rubins HB, 2002, ARCH INTERN MED, V162, P2597, DOI 10.1001/archinte.162.22.2597
   Rubins HB, 1999, NEW ENGL J MED, V341, P410, DOI 10.1056/NEJM199908053410604
   Sakamoto J, 2000, BIOCHEM BIOPH RES CO, V278, P704, DOI 10.1006/bbrc.2000.3868
   Samaha FF, 2006, ARTERIOSCL THROM VAS, V26, P624, DOI 10.1161/01.ATV.0000200136.56716.30
   Sarafidis PA, 2004, J HYPERTENS, V22, P1769, DOI 10.1097/00004872-200409000-00022
   Satoh N, 2003, DIABETES CARE, V26, P2493, DOI 10.2337/diacare.26.9.2493
   Schlesinger Z, 2000, CIRCULATION, V102, P21, DOI 10.1161/01.CIR.102.1.21
   SCHOONJANS K, 1995, J BIOL CHEM, V270, P19269, DOI 10.1074/jbc.270.33.19269
   Sebestjen M, 2004, THROMB HAEMOSTASIS, V92, P1129, DOI 10.1160/TH03-04-0250
   Seki N, 2005, ATHEROSCLEROSIS, V178, P1, DOI 10.1016/j.atherosclerosis.2004.08.015
   Serruys PWJC, 2002, JAMA-J AM MED ASSOC, V287, P3215, DOI 10.1001/jama.287.24.3215
   Sever PS, 2003, LANCET, V361, P1149, DOI 10.1016/S0140-6736(03)12948-0
   Shepherd J, 2002, LANCET, V360, P1623, DOI 10.1016/S0140-6736(02)11600-X
   Shu H, 2000, BIOCHEM BIOPH RES CO, V267, P345, DOI 10.1006/bbrc.1999.1968
   Shulman AI, 2005, NEW ENGL J MED, V353, P604, DOI 10.1056/NEJMra043590
   Sidhu JS, 2004, ARTERIOSCL THROM VAS, V24, P930, DOI 10.1161/01.ATV.0000124890.40436.77
   Staels B, 1998, ATHEROSCLEROSIS, V137, pS19, DOI 10.1016/S0021-9150(97)00313-4
   STAELS B, 1995, J CLIN INVEST, V95, P705, DOI 10.1172/JCI117717
   Staels B, 1998, NATURE, V393, P790, DOI 10.1038/31701
   STAMLER J, 1993, DIABETES CARE, V16, P434, DOI 10.2337/diacare.16.2.434
   Stearne MR, 1998, BMJ-BRIT MED J, V317, P703
   Steiner G, 2001, LANCET, V357, P905
   Tan GD, 2005, DIABETOLOGIA, V48, P83, DOI 10.1007/s00125-004-1619-9
   Tenenbaum A, 2005, ARCH INTERN MED, V165, P1154, DOI 10.1001/archinte.165.10.1154
   TENKANEN L, 1995, CIRCULATION, V92, P1779, DOI 10.1161/01.CIR.92.7.1779
   Thompson PD, 2006, AM J CARDIOL, V97, p69C, DOI 10.1016/j.amjcard.2005.12.013
   Tordjman K, 2001, J CLIN INVEST, V107, P1025, DOI 10.1172/JCI11497
   Turner RC, 1998, LANCET, V352, P854, DOI 10.1016/s0140-6736(98)07037-8
   Van Wijk JPH, 2005, DIABETES CARE, V28, P844, DOI 10.2337/diacare.28.4.844
   Vega GL, 2003, AM J CARDIOL, V91, P956, DOI 10.1016/S0002-9149(03)00111-5
   Wang G, 2005, METABOLISM, V54, P590, DOI 10.1016/j.metabol.2004.11.017
   Wild S, 2004, DIABETES CARE, V27, P1047, DOI 10.2337/diacare.27.5.1047
   Xiang AH, 2006, DIABETES, V55, P517, DOI 10.2337/diabetes.55.02.06.db05-1066
   Yan SF, 2003, CIRC RES, V93, P1159, DOI 10.1161/01.RES.0000103862.26506.3D
   Yki-Jarvinen H, 2004, NEW ENGL J MED, V351, P1106, DOI 10.1056/NEJMra041001
   Ziouzenkova O, 2003, J BIOL CHEM, V278, P39874, DOI 10.1074/jbc.M306786200
NR 149
TC 102
Z9 115
U1 1
U2 7
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
EI 1879-1913
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD FEB 19
PY 2007
VL 99
IS 4A
SU S
BP 27B
EP 40B
DI 10.1016/j.amjcard.2006.11.004
PG 14
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 143FR
UT WOS:000244705900005
PM 17307056
DA 2025-06-11
ER

PT J
AU Xu, YJ
   Sutanto, CN
   Xia, XJ
   Toh, DWK
   Gan, AX
   Deng, QY
   Ling, LH
   Khoo, CM
   Foo, RSY
   Kim, JE
AF Xu, Yujing
   Sutanto, Clarinda Nataria
   Xia, Xuejuan
   Toh, Darel Wee Kiat
   Gan, Alicia Xinli
   Deng, Qiyun
   Ling, Lieng Hsi
   Khoo, Chin Meng
   Foo, Roger Sik-Yin
   Kim, Jung Eun
TI Consumption of plant sterols-enriched soy milk with a healthy dietary
   pattern diet lowers blood pressure in adults with metabolic syndrome: A
   randomized controlled trial
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Cardiovascular disease; Endothelial function; Plant sterols; Healthy
   dietary pattern; Blood pressure; Metabolic syndrome
ID ENDOTHELIAL PROGENITOR CELLS; NITRIC-OXIDE; CIRCADIAN PATTERN; OXIDATIVE
   STRESS; SMOOTH-MUSCLE; CHOLESTEROL; MARKERS; INFLAMMATION; COMPONENTS;
   OBESITY
AB Background & aims: Plant sterols (PS) have been shown to lower blood lipid-lipoproteins concentrations and may serve as a potential functional ingredient for cardiovascular disease (CVD) risk management. However, there are limited studies examining this effect in individuals with metabolic syndrome (MetS). The aim of this study was to evaluate the effects of PS-enriched food consumption as part of a healthy dietary pattern (HDP) on blood pressure and endothelial function in Singaporean adults with MetS. Methods and results: This was a 12-week, crossover, randomized controlled trial with a 4-week washout period. Thirteen subjects were instructed to consume an HDP diet either with normal soy milk (control group) or with PS (2 g/day)-enriched soy milk (PS group) for 4 weeks. Blood lipid-lipoproteins and glucose concentrations, blood pressure, and endothelial function-related indicators (flow-mediated dilation, total plasma nitrate/nitrite and endothelin-1, circulating endothelial progenitor cells) were assessed before and after the intervention. Systolic blood pressure [mean change, PS group: -4.0 f 3.7 mmHg; control group: 5.9 f 2.5 mmHg (PInteraction = 0.01)] and long-term CVD risk [mean change, PS group: -0.2 f 1.0 %; control group: 2.7 f 1.3 % (PInteraction = 0.03)] decreased following PS consumption. No changes were observed in the other endothelial function-related outcomes. Conclusions: Consumption of PS-enriched food with an HDP diet may lower blood pressure and long-term CVD risk in adults with MetS. Clinical trial registration: NCT03723330, https://clinicaltrials.gov/.
C1 [Xu, Yujing; Sutanto, Clarinda Nataria; Xia, Xuejuan; Toh, Darel Wee Kiat; Gan, Alicia Xinli; Deng, Qiyun; Kim, Jung Eun] Natl Univ Singapore, Fac Sci, Dept Food Sci & Technol, Singapore, Singapore.
   [Xia, Xuejuan] Univ Shanghai Sci & Technol, Sch Hlth Sci & Engn, Shanghai, Peoples R China.
   [Ling, Lieng Hsi] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore.
   [Ling, Lieng Hsi] Natl Univ Heart Ctr, Dept Cardiol, Singapore, Singapore.
   [Khoo, Chin Meng] Natl Univ Singapore Hosp, Univ Med Cluster, Div Endocrinol, Singapore, Singapore.
   [Foo, Roger Sik-Yin] Natl Univ Singapore, Cardiovasc Res Inst, Yong Loo Lin Sch Med, Singapore, Singapore.
   [Foo, Roger Sik-Yin] Genome Inst Singapore, Singapore, Singapore.
C3 National University of Singapore; University of Shanghai for Science &
   Technology; National University of Singapore; National University of
   Singapore; National University of Singapore; National University of
   Singapore; Agency for Science Technology & Research (A*STAR); A*STAR -
   Genome Institute of Singapore (GIS)
RP Kim, JE (corresponding author), Natl Univ Singapore, Fac Sci, Dept Food Sci & Technol, Singapore, Singapore.
EM fstkje@nus.edu.sg
RI xu, yujing/GYJ-2312-2022; Khoo, Chin Meng/AAD-8790-2022; Kim, Jung
   Eun/LWI-5710-2024; Kim, Jung Eun/O-9332-2017
OI Khoo, Chin Meng/0000-0003-1601-2391; Xu, Yujing/0009-0009-3424-5974;
   Kim, Jung Eun/0000-0002-3912-9042; Toh, Darel Wee
   Kiat/0000-0003-1608-0669; Ling, Lieng H./0000-0001-6063-8530
FU BASF Singapore
FX This study is supported by BASF Singapore. Representatives from the BASF
   Singapore were not involved in the design implementation, analysis, or
   interpretation of data from this investigator-initiated study.
CR Akhlaghi M, 2024, CRIT REV FOOD SCI, V64, P3139, DOI 10.1080/10408398.2022.2130160
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   [Anonymous], 2011, Waist Circumference and Waist-Hip Ratio: Report of a WHO Expert Consultation
   [Anonymous], 2019, GAO analysis of U.S. Department of Agriculture (USDA) and FHA loan-level data
   Awad AB, 2001, PROSTAG LEUKOTR ESS, V64, P323, DOI 10.1054/plef.2001.0273
   Canale MP, 2021, NUTRIENTS, V13, DOI 10.3390/nu13041162
   Chan DC, 2004, CLIN SCI, V107, P233, DOI 10.1042/CS20040109
   Chan DC, 2003, OBES RES, V11, P591, DOI 10.1038/oby.2003.83
   Chau YP, 2020, EUR J NUTR, V59, P2739, DOI 10.1007/s00394-019-02119-w
   Chen YH, 2007, DIABETES, V56, P1559, DOI 10.2337/db06-1103
   Cheung CL, 2017, SCI REP-UK, V7, DOI 10.1038/srep41084
   D'Agostino RB, 2008, CIRCULATION, V117, P743, DOI 10.1161/CIRCULATIONAHA.107.699579
   De Jong A, 2008, EUR J CLIN NUTR, V62, P263, DOI 10.1038/sj.ejcn.1602733
   Demonty I, 2009, J NUTR, V139, P271, DOI 10.3945/jn.108.095125
   Droyvold WB, 2005, INT J OBESITY, V29, P650, DOI 10.1038/sj.ijo.0802944
   Eslami O, 2019, COMPLEMENT THER MED, V42, P82, DOI 10.1016/j.ctim.2018.11.001
   Eslami O, 2019, J AM COLL NUTR, V38, P51, DOI [10.1080/07315724.2018.1479990, 10.1080/07]
   Fatahi S, 2019, NUTR METAB CARDIOVAS, V29, P1168, DOI 10.1016/j.numecd.2019.07.011
   Ferrier KE, 2002, J AM COLL CARDIOL, V39, P1020, DOI 10.1016/S0735-1097(02)01717-5
   Fetalvero KM, 2007, PROSTAG OTH LIPID M, V82, P109, DOI 10.1016/j.prostaglandins.2006.05.011
   Fezeu L, 2014, CHRONOBIOL INT, V31, P861, DOI 10.3109/07420528.2014.917090
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Frigolet ME, 2013, J NUTR BIOCHEM, V24, P2003, DOI 10.1016/j.jnutbio.2013.07.002
   Ghaedi E, 2020, CLIN NUTR, V39, P2702, DOI 10.1016/j.clnu.2019.12.020
   Ghiadoni L, 2012, CURR VASC PHARMACOL, V10, P42, DOI 10.2174/157016112798829823
   Gladwin MT, 2006, AM J PHYSIOL-HEART C, V291, pH2026, DOI 10.1152/ajpheart.00407.2006
   Godos J, 2017, INT J FOOD SCI NUTR, V68, P138, DOI 10.1080/09637486.2016.1221900
   Guerrot D, 2011, J CLIN ENDOCR METAB, V96, pE929, DOI 10.1210/jc.2010-2337
   Hall JE, 2010, J BIOL CHEM, V285, P17271, DOI 10.1074/jbc.R110.113175
   Hautaniemi EJ, 2015, BRIT J NUTR, V114, P376, DOI 10.1017/S0007114515002032
   Health Promotion Board, 2011, EN NUTR COMP FOOD
   Health Promotion Board, 2020, My Healthy Plate
   Heggen E, 2015, SCAND J CLIN LAB INV, V75, P189, DOI 10.3109/00365513.2014.992040
   Hermann Matthias, 2006, J Clin Hypertens (Greenwich), V8, P17, DOI 10.1111/j.1524-6175.2006.06032.x
   Hermida RC, 2009, AM J HYPERTENS, V22, P307, DOI 10.1038/ajh.2008.358
   Ho XL, 2017, J FOOD SCI, V82, P1750, DOI 10.1111/1750-3841.13752
   Holmen J, 2016, BMC CARDIOVASC DISOR, V16, DOI 10.1186/s12872-016-0257-8
   Huang ZW, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-19001-1
   Ibernon M, 2012, NEPHROL DIAL TRANSPL, V27, P2089, DOI 10.1093/ndt/gfr587
   Irani K, 2000, CIRC RES, V87, P179, DOI 10.1161/01.RES.87.3.179
   Izzedine H, 2006, INT J CARDIOL, V107, P343, DOI 10.1016/j.ijcard.2005.03.046
   Jauhiainen T, 2012, EUR J CLIN NUTR, V66, P843, DOI 10.1038/ejcn.2012.44
   Johnson JA, 2008, CIRCULATION, V118, P1383, DOI 10.1161/CIRCULATIONAHA.107.704023
   Jones PJH, 2018, NUTR REV, V76, P725, DOI 10.1093/nutrit/nuy032
   Kang GD, 2010, CIRC J, V74, P456, DOI 10.1253/circj.CJ-09-0422
   Katan MB, 2003, MAYO CLIN PROC, V78, P965, DOI 10.4065/78.8.965
   Kelm M, 2002, AM J PHYSIOL-HEART C, V282, pH1, DOI 10.1152/ajpheart.2002.282.1.H1
   Keymel S, 2008, BASIC RES CARDIOL, V103, P582, DOI 10.1007/s00395-008-0742-z
   Landberg R, 2012, CURR OPIN LIPIDOL, V23, P147, DOI 10.1097/MOL.0b013e328351123a
   Lee EPX, 2022, INT J GERIATR PSYCH, V37, DOI 10.1002/gps.5645
   Lin XB, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0116912
   Mak A, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-07574-1
   Mensink RP, 2002, ATHEROSCLEROSIS, V160, P205, DOI 10.1016/S0021-9150(01)00562-7
   Mozaffarian D, 2016, CIRCULATION, V133, P187, DOI 10.1161/CIRCULATIONAHA.115.018585
   Na MZ, 2022, J NUTR, V152, P1755, DOI 10.1093/jn/nxac086
   National Cholesterol Education Program, 2001, ATP III final report)
   Ooi EM, 2007, ASIA PAC J CLIN NUTR, V16, P624
   Plat J, 2009, J NUTR, V139, P1143, DOI 10.3945/jn.108.103481
   Ras RT, 2015, AM J CLIN NUTR, V101, P733, DOI 10.3945/ajcn.114.102053
   Rassaf T, 2002, J CLIN INVEST, V109, P1241, DOI 10.1172/JCI200214995
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Seeger FH, 2005, CIRCULATION, V111, P1184, DOI 10.1161/01.CIR.0000157156.85397.A1
   Shin CY, 2009, ATHEROSCLEROSIS, V205, P614, DOI 10.1016/j.atherosclerosis.2009.01.014
   Sialvera TE, 2012, NUTR METAB CARDIOVAS, V22, P843, DOI 10.1016/j.numecd.2010.12.004
   STAMLER J, 1989, HYPERTENSION, V14, P570, DOI 10.1161/01.HYP.14.5.570
   Stauss HM, 2000, NEWS PHYSIOL SCI, V15, P229
   Suzuki T, 2008, AM HEART J, V156, P405, DOI 10.1016/j.ahj.2008.02.022
   Tanaka M, 2020, HYPERTENS RES, V43, P79, DOI 10.1038/s41440-019-0348-x
   Trautwein EA, 2003, EUR J LIPID SCI TECH, V105, P171, DOI 10.1002/ejlt.200390033
   Turpeinen AM, 2012, FOOD FUNCT, V3, P621, DOI 10.1039/c2fo10286b
   Who, 2021, Cardiovascular Diseases (CVDs)
   Xia XJ, 2022, FOOD FUNCT, V13, P76, DOI [10.1039/D1FO02369A, 10.1039/d1fo02369a]
   Zhang M, 2014, CURR OPIN HEMATOL, V21, P224, DOI 10.1097/MOH.0000000000000041
NR 73
TC 0
Z9 0
U1 3
U2 5
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD JAN
PY 2025
VL 35
IS 1
AR 103773
DI 10.1016/j.numecd.2024.10.011
EA NOV 2024
PG 9
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA M9G4B
UT WOS:001360539700001
PM 39561689
DA 2025-06-11
ER

PT J
AU Bagetta, D
   Maruca, A
   Lupia, A
   Mesiti, F
   Catalano, R
   Romeo, I
   Moraca, F
   Ambrosio, FA
   Costa, G
   Artese, A
   Ortuso, F
   Alcaro, S
   Rocca, R
AF Bagetta, Donatella
   Maruca, Annalisa
   Lupia, Antonio
   Mesiti, Francesco
   Catalano, Raffaella
   Romeo, Isabella
   Moraca, Federica
   Ambrosio, Francesca Alessandra
   Costa, Giosue
   Artese, Anna
   Ortuso, Francesco
   Alcaro, Stefano
   Rocca, Roberta
TI Mediterranean products as promising source of multi-target agents in the
   treatment of metabolic syndrome
SO EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
DE Metabolic syndrome (MetS); Mediterranean diet (MedDiet); Multi-target;
   Polypharmacology; Prevention; Anti-oxidant; Anti-inflammatory;
   Polyphenols
ID DIET-INDUCED OBESITY; VIRGIN OLIVE OIL; CROCUS-SATIVUS L.; INHIBIT
   ADIPOCYTE DIFFERENTIATION; PERFORMANCE LIQUID-CHROMATOGRAPHY; ROSEMARY
   ROSMARINUS-OFFICINALIS; CARDIOVASCULAR-DISEASE RISK; ACTIVATED
   PROTEIN-KINASE; CITRUS-BERGAMIA RISSO; HMG-COA REDUCTASE
AB Alteration of nutritional habits play an essential role on the risk of developing Metabolic Syndrome (MetS). Several epidemiological studies have shown that assuming diets rich of foods included in the Mediterranean diet (MetDiet) pattern like, such as olive oil, nuts, fruit, fiber, vegetables, wine and grain cereals has protective effects on the different risk factors characterizing the MetS. The beneficial effects of the MetDiet in the MetS are mainly due to the antioxidant and anti-inflammatory properties of the most abundant phytochemical components of such foods as polyphenols like resveratrol and oleuropein, allyl sulfides, ellagic acid, mono- and poly-unsaturated fatty acids (MUFA and PUFA), tocopherols and flavonoids like quercetin, which have shown positive results in the prevention of cardiovascular diseases (CVDs), with related risk factors, like hypertension, hypercholesterolemia and obesity. In this review, we highlighted the multi-target activities of the bioactive components contained in some foods typical of the Mediterranean area like olive oil, onion, liquorice, rosemary, oregano, hazelnut, pistachio, "Melannurca" apple, red wine, hot pepper, Citrus sp. fruits, saffron and garlic, with particular focus on their impact on health outcomes in relation to MetS main key factors, such as insulin resistance (IR) and type 2 diabetes mellitus (T2DM), endothelial dysfunctions, inflammatory response, oxidative stress and dyslipidaemic and hypercholesterolemic effects. (C) 2019 Elsevier Masson SAS. All rights reserved.
C1 [Bagetta, Donatella; Maruca, Annalisa; Lupia, Antonio; Mesiti, Francesco; Catalano, Raffaella; Ambrosio, Francesca Alessandra; Costa, Giosue; Artese, Anna; Ortuso, Francesco; Alcaro, Stefano] Magna Graecia Univ Catanzaro, Dipartimento Sci Salute, Campus Salvatore Venuta,Viale Europa, I-88100 Catanzaro, Italy.
   [Bagetta, Donatella; Maruca, Annalisa; Lupia, Antonio; Mesiti, Francesco; Catalano, Raffaella; Romeo, Isabella; Moraca, Federica; Costa, Giosue; Artese, Anna; Ortuso, Francesco; Alcaro, Stefano; Rocca, Roberta] Magna Graecia Univ Catanzaro, Net4Science Srl, Campus Salvatore Venuta,Viale Europa, I-88100 Catanzaro, Italy.
   [Romeo, Isabella] Univ Calabria, Dept Chem & Chem Technol, Via Pietro Bucci, I-87036 Arcavacata Di Rende, Italy.
   [Moraca, Federica] Univ Naples Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy.
   [Rocca, Roberta] Magna Graecia Univ Catanzaro, Dept Expt & Clin Med, Campus Salvatore Venuta,Viale Europa, I-88100 Catanzaro, Italy.
C3 Magna Graecia University of Catanzaro; Magna Graecia University of
   Catanzaro; University of Calabria; University of Naples Federico II;
   Magna Graecia University of Catanzaro
RP Ambrosio, FA (corresponding author), Magna Graecia Univ Catanzaro, Dipartimento Sci Salute, Campus Salvatore Venuta,Viale Europa, I-88100 Catanzaro, Italy.; Moraca, F (corresponding author), Magna Graecia Univ Catanzaro, Net4Science Srl, Campus Salvatore Venuta,Viale Europa, I-88100 Catanzaro, Italy.
EM federica.moraca@unina.it; ambrosio@unicz.it
RI Rocca, Roberta/L-7431-2016; Catalano, Raffaella/HDO-3350-2022; Romeo,
   Isabella/ACS-6478-2022; Lupia, Antonio/CAH-2362-2022; Costa,
   Giosue/K-8461-2016
OI ALCARO, Stefano/0000-0002-0437-358X; Maruca,
   Annalisa/0000-0002-6537-552X; Catalano, Raffaella/0000-0003-3936-3573;
   Mesiti, Francesco/0000-0002-9968-4996; Costa,
   Giosue/0000-0003-0947-9479; Lupia, Antonio/0000-0003-0870-2376
FU  [201744BN5T]
FX The authors acknowledge the PRIN 2017 research project "Novel anticancer
   agents endowed with multi-targeting mechanism of action" [Project n.
   201744BN5T].
CR Abete I, 2011, NUTR METAB CARDIOVAS, V21, pB1, DOI 10.1016/j.numecd.2011.05.001
   Abo-Ghanema I., 2012, INT J MED BIOSCI, V6, P181, DOI [10.5281/zenodo.1083815, DOI 10.5281/ZENODO.1083815]
   Ahima RS, 2008, ENDOCRIN METAB CLIN, V37, P811, DOI 10.1016/j.ecl.2008.08.005
   Ahmed Osama Mohamed, 2010, Diabetologia Croatica, V39, P15
   Alam MA, 2014, ADV NUTR, V5, P404, DOI 10.3945/an.113.005603
   Alam MM, 2015, INT J BIOL MACROMOL, V79, P336, DOI 10.1016/j.ijbiomac.2015.05.004
   Flores MIA, 2012, FOOD CHEM, V134, P2465, DOI 10.1016/j.foodchem.2012.04.058
   Alasalvar C, 2003, J AGR FOOD CHEM, V51, P3790, DOI 10.1021/jf0212385
   Alcaro S, 2019, FRONT CHEM, V7, DOI 10.3389/fchem.2019.00071
   Alqahtani A, 2013, CURR MED CHEM, V20, P908
   Amaral JS, 2006, J AGR FOOD CHEM, V54, P1315, DOI 10.1021/jf052287v
   Amiot MJ, 2016, OBES REV, V17, P573, DOI 10.1111/obr.12409
   [Anonymous], 2017, OXID MED CELL LONGEV
   [Anonymous], DIETARY GUIDELINES A
   [Anonymous], 2015, MEDITERRANEAN DIET E
   [Anonymous], HLTH BENEFITS HAZELN
   [Anonymous], 2011, International Journal of Clinical Metabolism and Diabetes
   [Anonymous], IRAN RED CRESCENT ME
   [Anonymous], 2016, INT FOOD RES J, DOI DOI 10.1155/2018/9589472
   [Anonymous], GARL REV ITS MED EFF
   [Anonymous], TROPICAL SUBTROPICAL
   [Anonymous], EFFECT IRRADIATION C
   [Anonymous], J PHARM TOXICOL
   [Anonymous], SCI WORLD J
   Arslan M, 2012, EXP AGR, V48, P428, DOI 10.1017/S0014479712000075
   Artero A, 2015, MATURITAS, V80, P3, DOI 10.1016/j.maturitas.2014.09.007
   Asdaq SMB, 2010, APPL BIOCHEM BIOTECH, V162, P358, DOI 10.1007/s12010-009-8740-7
   Asgary S, 2018, J AM COLL NUTR, V37, P429, DOI 10.1080/07315724.2017.1410867
   Astrup A, 2000, ENDOCRINE, V13, P207, DOI 10.1385/ENDO:13:2:207
   Azizi A, 2009, IND CROP PROD, V29, P554, DOI 10.1016/j.indcrop.2008.11.001
   Baek J, 2013, NUTR RES PRACT, V7, P96, DOI 10.4162/nrp.2013.7.2.96
   Baldi A, 1995, J CHROMATOGR A, V718, P89, DOI 10.1016/0021-9673(95)00676-1
   Baltina LA, 2003, CURR MED CHEM, V10, P155, DOI 10.2174/0929867033368538
   Bar-Magen T, 2010, J VIROL, V84, P9210, DOI 10.1128/JVI.01164-10
   Bashford D, 2000, ANNU REV PHYS CHEM, V51, P129, DOI 10.1146/annurev.physchem.51.1.129
   Baskaran P, 2017, INT J OBESITY, V41, P739, DOI 10.1038/ijo.2017.16
   Baskaran P, 2016, BRIT J PHARMACOL, V173, P2369, DOI 10.1111/bph.13514
   Bayram B, 2012, PLANT FOOD HUM NUTR, V67, P326, DOI 10.1007/s11130-012-0315-z
   Benavente-García O, 2008, J AGR FOOD CHEM, V56, P6185, DOI 10.1021/jf8006568
   Bermúdez-Soto MJ, 2007, FOOD CHEM, V102, P865, DOI 10.1016/j.foodchem.2006.06.025
   Bernini R, 2013, CURR MED CHEM, V20, P655, DOI 10.2174/092986713804999367
   Berrougui H, 2009, ATHEROSCLEROSIS, V207, P420, DOI 10.1016/j.atherosclerosis.2009.05.017
   Birari RB, 2011, PHYTOMEDICINE, V18, P795, DOI 10.1016/j.phymed.2011.01.002
   Boden G, 2001, AM J PHYSIOL-ENDOC M, V280, pE23, DOI 10.1152/ajpendo.2001.280.1.E23
   Bogani P, 2007, ATHEROSCLEROSIS, V190, P181, DOI 10.1016/j.atherosclerosis.2006.01.011
   Boskabady MH, 2008, PHYTOTHER RES, V22, P330, DOI 10.1002/ptr.2317
   Bostan HB, 2017, IRAN J BASIC MED SCI, V20, P110, DOI 10.22038/ijbms.2017.8230
   Bozin B, 2006, J AGR FOOD CHEM, V54, P1822, DOI 10.1021/jf051922u
   Brewster J. L., 2008, Onions and other vegetable alliums, DOI 10.1079/9781845933999.0000
   Buchin Y, 2019, PHYTOCHEM LETT, V30, P43, DOI 10.1016/j.phytol.2019.01.005
   Bulotta S, 2014, J TRANSL MED, V12, DOI 10.1186/s12967-014-0219-9
   Bystrická J, 2013, ACTA ALIMENT HUNG, V42, P11, DOI 10.1556/AAlim.42.2013.1.2
   Cai EP, 2009, J AGR FOOD CHEM, V57, P9817, DOI 10.1021/jf902618v
   Cao K, 2014, FREE RADICAL BIO MED, V67, P396, DOI 10.1016/j.freeradbiomed.2013.11.029
   Carrasco-Pancorbo A, 2005, J SEP SCI, V28, P837, DOI 10.1002/jssc.200500032
   Casaburi I, 2013, MOL NUTR FOOD RES, V57, P71, DOI 10.1002/mnfr.201200503
   Charles D.J., 2013, ANTIOXIDANT PROPERTI
   Chen HJ, 2014, J AGR FOOD CHEM, V62, P618, DOI 10.1021/jf405352g
   Cho IJ, 2008, BIOCHEM BIOPH RES CO, V367, P190, DOI 10.1016/j.bbrc.2007.12.140
   Cho S, 2012, J NUTR BIOCHEM, V23, P192, DOI 10.1016/j.jnutbio.2010.11.016
   Choe SC, 2001, J CARDIOVASC PHARM, V38, P947, DOI 10.1097/00005344-200112000-00017
   Choi SY, 2007, J ETHNOPHARMACOL, V113, P149, DOI 10.1016/j.jep.2007.05.021
   Corzo-Martínez M, 2007, TRENDS FOOD SCI TECH, V18, P609, DOI 10.1016/j.tifs.2007.07.011
   Croft KD, 1998, ANN NY ACAD SCI, V854, P435, DOI 10.1111/j.1749-6632.1998.tb09922.x
   de Bock M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057622
   de Paula FT, 2013, CHEM BIOL DRUG DES, V82, P756, DOI 10.1111/cbdd.12204
   Dehghan F, 2016, SCI REP-UK, V6, DOI 10.1038/srep25139
   Dekdouk N, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/684925
   Del Prete D, 2015, BIOORG MED CHEM LETT, V25, P1009, DOI 10.1016/j.bmcl.2015.01.039
   Deng YH, 2011, PHYTOTHER RES, V25, P451, DOI 10.1002/ptr.3279
   Dennis EG, 2012, J AGR FOOD CHEM, V60, P2638, DOI 10.1021/jf2042517
   Di Donna L, 2014, J FUNCT FOODS, V7, P558, DOI 10.1016/j.jff.2013.12.029
   Di Renzo L, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/4683723
   Díaz-Juárez JA, 2009, PHYTOTHER RES, V23, P948, DOI 10.1002/ptr.2680
   Do Myoung-Sool, 2004, Preventive Nutrition and Food Science, V9, P34
   Dosoky NS, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19071966
   Drira R, 2014, EUR J NUTR, V53, P743, DOI 10.1007/s00394-013-0578-7
   Dugo P, 2005, J SEP SCI, V28, P1149, DOI 10.1002/jssc.200500053
   Ebaid GMX, 2010, NUTR J, V9, DOI 10.1186/1475-2891-9-46
   Eid HM, 2015, PHARMACOGN MAG, V11, P74, DOI 10.4103/0973-1296.149708
   El Hadi H, 2019, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01954
   El SN, 2009, NUTR REV, V67, P632, DOI 10.1111/j.1753-4887.2009.00248.x
   Erkan N, 2008, FOOD CHEM, V110, P76, DOI 10.1016/j.foodchem.2008.01.058
   Esmaeili MA, 2009, PLANTA MED, V75, P1418, DOI 10.1055/s-0029-1185704
   Estruch R, 2006, ANN INTERN MED, V145, P1, DOI 10.7326/0003-4819-145-1-200607040-00004
   Favela-Hernández JMJ, 2016, MOLECULES, V21, DOI 10.3390/molecules21020247
   FENWICK GR, 1990, FOOD CHEM, V38, P119, DOI 10.1016/0308-8146(90)90159-2
   Fernandes GD, 2017, J CHEM-NY, V2017, DOI 10.1155/2017/2609549
   Fernandes I, 2017, MOLECULES, V22, DOI 10.3390/molecules22020292
   Ferrara LA, 2000, ARCH INTERN MED, V160, P837, DOI 10.1001/archinte.160.6.837
   Filippatos TD, 2008, DRUG SAFETY, V31, P53, DOI 10.2165/00002018-200831010-00005
   Fitó M, 2005, ATHEROSCLEROSIS, V181, P149, DOI 10.1016/j.atherosclerosis.2004.12.036
   Foti MC, 2007, J PHARM PHARMACOL, V59, P1673, DOI 10.1211/jpp.59.12.0010
   Fritsch P, 2010, ATHEROSCLEROSIS, V212, P650, DOI 10.1016/j.atherosclerosis.2010.06.028
   de Mendoza MF, 2013, FOOD CHEM, V141, P2575, DOI 10.1016/j.foodchem.2013.05.074
   Fugh-Berman A, 2004, EXP BIOL MED, V229, P698, DOI 10.1177/153537020422900802
   Fukuchi Y, 2008, J CLIN BIOCHEM NUTR, V43, P201, DOI 10.3164/jcbn.2008066
   Gamboa-Gómez CI, 2015, EXCLI J, V14, P809, DOI 10.17179/excli2015-186
   Gebauer SK, 2008, AM J CLIN NUTR, V88, P651, DOI 10.1093/ajcn/88.3.651
   Ghirardello D, 2013, POSTHARVEST BIOL TEC, V81, P37, DOI 10.1016/j.postharvbio.2013.02.014
   Giacosa A, 2016, CRIT REV FOOD SCI, V56, P635, DOI 10.1080/10408398.2012.747484
   Gidaro MC, 2015, PLANTA MED, V81, P533, DOI 10.1055/s-0034-1396139
   Göçmen AY, 2011, APPL PHYSIOL NUTR ME, V36, P323, DOI [10.1139/h11-022, 10.1139/H11-022]
   GONZALEZ M, 1992, PLANTA MED, V58, P513, DOI 10.1055/s-2006-961538
   González-Molina E, 2008, J AGR FOOD CHEM, V56, P1669, DOI 10.1021/jf073282w
   Gutiérrez-Grijalva EP, 2019, FOOD RES INT, V116, P676, DOI 10.1016/j.foodres.2018.08.096
   Haaz S, 2006, OBES REV, V7, P79, DOI 10.1111/j.1467-789X.2006.00195.x
   Hashmi MA, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/541591
   Haskó G, 2010, AM J PHYSIOL-HEART C, V299, pH10, DOI 10.1152/ajpheart.00436.2010
   Hassani FV, 2016, N-S ARCH PHARMACOL, V389, P931, DOI 10.1007/s00210-016-1256-0
   Hassen I, 2015, J FUNCT FOODS, V18, P926, DOI 10.1016/j.jff.2014.09.001
   Hawryluk NA, 2010, BIOORG MED CHEM LETT, V20, P7137, DOI 10.1016/j.bmcl.2010.09.023
   He Shu-ying, 2004, Yaoxue Xuebao, V39, P778
   Higashino S, 2014, PHYTOTHER RES, V28, P1315, DOI 10.1002/ptr.5130
   Honda K, 2013, BIOSCI BIOTECH BIOCH, V77, P1326, DOI 10.1271/bbb.130104
   Hopkins AL, 2008, NAT CHEM BIOL, V4, P682, DOI 10.1038/nchembio.118
   Hsu CL, 2007, J AGR FOOD CHEM, V55, P1730, DOI 10.1021/jf062912b
   Hwang JT, 2005, BIOCHEM BIOPH RES CO, V338, P694, DOI 10.1016/j.bbrc.2005.09.195
   Imenshahidi M, 2010, PHYTOTHER RES, V24, P990, DOI 10.1002/ptr.3044
   Impellizzeri D, 2016, FRONT PHARMACOL, V7, DOI 10.3389/fphar.2016.00203
   Jackson R., 2000, Wine Science: Principle, Practice, Perception
   Jakobs S, 2006, MOL NUTR FOOD RES, V50, P52, DOI 10.1002/mnfr.200500163
   Janssens PLHR, 2014, APPETITE, V77, P44, DOI 10.1016/j.appet.2014.02.018
   Jayanthy G., 2014, Biomedicine & Preventive Nutrition, V4, P431
   Jemai H, 2009, J AGR FOOD CHEM, V57, P8798, DOI 10.1021/jf901280r
   Jenkins DJA, 2011, DIABETES CARE, V34, P1706, DOI 10.2337/dc11-0338
   Jones MG, 2004, J EXP BOT, V55, P1903, DOI 10.1093/jxb/erh138
   Kamalipour Maryam, 2011, J Tehran Heart Cent, V6, P59
   Kang C, 2012, FOOD CHEM, V135, P2350, DOI 10.1016/j.foodchem.2012.06.092
   Kang JH, 2007, FEBS LETT, V581, P4389, DOI 10.1016/j.febslet.2007.07.082
   Kappel VD, 2013, J PHARM PHARMACOL, V65, P1179, DOI 10.1111/jphp.12066
   Kataya HH, 2011, DRUG CHEM TOXICOL, V34, P101, DOI 10.3109/01480545.2010.510524
   Kay CD, 2010, J NUTR, V140, P1093, DOI 10.3945/jn.109.117366
   Kianbakht S., 2015, Journal of Medicinal Plants, V14, P25
   Kim JS, 2000, BIOSCI BIOTECH BIOCH, V64, P2458, DOI 10.1271/bbb.64.2458
   Kim MS, 2012, MOL CELL ENDOCRINOL, V358, P127, DOI 10.1016/j.mce.2012.03.013
   Kim Y, 2010, BIOTECHNOL J, V5, P950, DOI 10.1002/biot.201000068
   Kiritsakis A, 1987, Adv Food Res, V31, P453
   Krichene D, 2015, J AGR FOOD CHEM, V63, P6779, DOI 10.1021/acs.jafc.5b02187
   Kumar B, 2014, EXP EYE RES, V125, P193, DOI 10.1016/j.exer.2014.06.009
   Kwon MJ, 2003, LIFE SCI, V72, P2953, DOI 10.1016/S0024-3205(03)00234-0
   Kwon YII, 2006, ASIA PAC J CLIN NUTR, V15, P107
   Labban L., 2014, International Journal of Clinical Medicine, V5, P297, DOI [10.4236/ijcm.2014.56044, DOI 10.4236/IJCM.2014.56044]
   LAFERRIERE J E, 1991, Journal of Ethnobiology, V11, P93
   Lee E, 2015, FASEB J, V29, P3182, DOI 10.1096/fj.14-268300
   Leopoldini M, 2010, J AGR FOOD CHEM, V58, P10768, DOI 10.1021/jf102576j
   Leyva-López N, 2016, J ETHNOPHARMACOL, V187, P302, DOI 10.1016/j.jep.2016.04.051
   Li J, 2010, PHYTOMEDICINE, V17, P800, DOI 10.1016/j.phymed.2010.02.004
   Li XD, 2021, NAT PROD RES, V35, P4265, DOI 10.1080/14786419.2019.1696792
   Li XJ, 2016, INT J MOL MED, V38, P1661, DOI 10.3892/ijmm.2016.2794
   Li YQ, 2009, J AGR FOOD CHEM, V57, P11463, DOI 10.1021/jf903083h
   Lida T, 2003, NEUROPHARMACOLOGY, V44, P958, DOI 10.1016/S0028-3908(03)00100-X
   Lin CM, 2002, BIOCHEM BIOPH RES CO, V294, P167, DOI 10.1016/S0006-291X(02)00442-4
   Lippi G, 2010, SEMIN THROMB HEMOST, V36, P59, DOI 10.1055/s-0030-1248725
   Liu LJ, 2002, J NUTR, V132, P1129, DOI 10.1093/jn/132.6.1129
   Liu YN, 2014, NUTR RES, V34, P450, DOI 10.1016/j.nutres.2014.04.007
   Lo Scalzo R, 2001, FOOD CHEM, V73, P333, DOI 10.1016/S0308-8146(00)00306-X
   Lockyer S, 2017, EUR J NUTR, V56, P1421, DOI 10.1007/s00394-016-1188-y
   Loizzo MR, 2011, J FOOD BIOCHEM, V35, P381, DOI 10.1111/j.1745-4514.2010.00390.x
   Lu Y, 2013, INT J MOL SCI, V14, P23736, DOI 10.3390/ijms141223736
   Ludy MJ, 2012, CHEM SENSES, V37, P103, DOI 10.1093/chemse/bjr100
   Malliou F, 2018, J NUTR BIOCHEM, V59, P17, DOI 10.1016/j.jnutbio.2018.05.013
   Marrelli M, 2016, PLANT FOOD HUM NUTR, V71, P301, DOI 10.1007/s11130-016-0560-7
   Martín-Peláez S, 2013, MOL NUTR FOOD RES, V57, P760, DOI 10.1002/mnfr.201200421
   Martínez-González MA, 2004, EUR J EPIDEMIOL, V19, P9, DOI 10.1023/B:EJEP.0000013351.60227.7b
   Mashmoul M, 2014, J FUNCT FOODS, V8, P180, DOI 10.1016/j.jff.2014.03.017
   Medina-Franco JL, 2013, DRUG DISCOV TODAY, V18, P495, DOI 10.1016/j.drudis.2013.01.008
   Medina-Remón A, 2013, MINI-REV MED CHEM, V13, P1137, DOI 10.2174/1389557511313080002
   Mercanligil SM, 2007, EUR J CLIN NUTR, V61, P212, DOI 10.1038/sj.ejcn.1602518
   Miceli N, 2007, J AGR FOOD CHEM, V55, P10671, DOI 10.1021/jf071772i
   Mikaili P, 2013, IRAN J BASIC MED SCI, V16, P1031
   Milne JC, 2007, NATURE, V450, P712, DOI 10.1038/nature06261
   Mirtaheri E, 2015, EUR J INTEGR MED, V7, P287, DOI 10.1016/j.eujim.2015.03.006
   Mohajeri D., 2009, Journal of Biological Sciences, V9, P302, DOI 10.3923/jbs.2009.302.310
   Mollace V, 2019, ENDOCR METAB IMMUNE, V19, P136, DOI 10.2174/1871530319666181203151513
   Mollace V, 2011, FITOTERAPIA, V82, P309, DOI 10.1016/j.fitote.2010.10.014
   Mollica A, 2018, J FUNCT FOODS, V47, P562, DOI 10.1016/j.jff.2018.06.016
   MONTEDORO G, 1992, J AGR FOOD CHEM, V40, P1571, DOI 10.1021/jf00021a019
   Moreno-Luna R, 2012, AM J HYPERTENS, V25, P1299, DOI 10.1038/ajh.2012.128
   Mueller M, 2008, J AGR FOOD CHEM, V56, P11621, DOI 10.1021/jf802298w
   Mueller M, 2011, PLANTA MED, V77, P497, DOI 10.1055/s-0030-1250435
   Myers MG, 2008, ANNU REV PHYSIOL, V70, P537, DOI 10.1146/annurev.physiol.70.113006.100707
   Naderi GA, 2003, MOL CELL BIOCHEM, V246, P193, DOI 10.1023/A:1023483223842
   Nagai K, 2014, AUTON NEUROSCI-BASIC, V185, P29, DOI 10.1016/j.autneu.2014.06.005
   Naimi M, 2017, NUTRIENTS, V9, DOI 10.3390/nu9090968
   Namazi N, 2017, ADV PHARM BULL, V7, P221, DOI 10.15171/apb.2017.027
   Nasiri Z, 2015, IRAN J BASIC MED SCI, V18, P1143
   NEGULESCO JA, 1987, ATHEROSCLEROSIS, V64, P85, DOI 10.1016/0021-9150(87)90233-4
   Ngo YL, 2018, FOOD CHEM TOXICOL, V121, P687, DOI 10.1016/j.fct.2018.09.064
   Franco MN, 2014, FOOD CHEM, V163, P289, DOI 10.1016/j.foodchem.2014.04.091
   Node K, 2009, CARDIOVASC DIABETOL, V8, DOI 10.1186/1475-2840-8-23
   Ohnuki K, 2001, BIOSCI BIOTECH BIOCH, V65, P2735, DOI 10.1271/bbb.65.2735
   Ohyama K, 2015, AM J PHYSIOL-ENDOC M, V308, pE315, DOI 10.1152/ajpendo.00354.2014
   Oi-Kano Y, 2017, J NUTR BIOCHEM, V40, P209, DOI 10.1016/j.jnutbio.2016.11.009
   Oluwatuyi M, 2004, PHYTOCHEMISTRY, V65, P3249, DOI 10.1016/j.phytochem.2004.10.009
   Onakpoya I, 2017, CRIT REV FOOD SCI, V57, P602, DOI 10.1080/10408398.2014.901292
   Owen RW, 2000, EUR J CANCER, V36, P1235, DOI 10.1016/S0959-8049(00)00103-9
   Ozcan L, 2009, CELL METAB, V9, P35, DOI 10.1016/j.cmet.2008.12.004
   Papoiu ADP, 2010, EXPERT OPIN PHARMACO, V11, P1359, DOI 10.1517/14656566.2010.481670
   Parham Mahmoud, 2014, Rev Diabet Stud, V11, P190, DOI 10.1900/RDS.2014.11.190
   PARIS A, 1993, J NAT PROD, V56, P1426, DOI 10.1021/np50098a031
   Park HG, 2012, J NUTR BIOCHEM, V23, P759, DOI 10.1016/j.jnutbio.2011.03.021
   Parkinson L, 2016, MOLECULES, V21, DOI 10.3390/molecules21121734
   Pawar S., 2011, International Journal of Pharmacy and Biological Sciences, V1, P311
   Pérez-Martínez P, 2011, CURR PHARM DESIGN, V17, P769, DOI 10.2174/138161211795428948
   Pirisi FM, 2000, J AGR FOOD CHEM, V48, P1191, DOI 10.1021/jf991137f
   Preuss Harry G., 2002, Journal of Medicine (Westbury), V33, P247
   Prince PSM, 2006, J BIOCHEM MOL TOXIC, V20, P96, DOI 10.1002/jbt.20117
   Priore P, 2014, J NUTR BIOCHEM, V25, P683, DOI 10.1016/j.jnutbio.2014.01.009
   Pu P, 2012, ARCH BIOCHEM BIOPHYS, V518, P61, DOI 10.1016/j.abb.2011.11.026
   Rahaiee S, 2015, J FOOD SCI TECH MYS, V52, P1881, DOI 10.1007/s13197-013-1238-x
   Ramprasath VR, 2010, EUR J CLIN NUTR, V64, P660, DOI 10.1038/ejcn.2010.77
   Ramsay RR, 2018, CLIN TRANSL MED, V7, DOI 10.1186/s40169-017-0181-2
   Rapisarda P, 2008, POSTHARVEST BIOL TEC, V49, P348, DOI 10.1016/j.postharvbio.2008.02.002
   Rau O, 2006, PLANTA MED, V72, P881, DOI 10.1055/s-2006-946680
   Reinbach HC, 2009, CLIN NUTR, V28, P260, DOI 10.1016/j.clnu.2009.01.010
   Rigacci S, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17060843
   Rocha J, 2015, BASIC CLIN PHARMACOL, V116, P398, DOI 10.1111/bcpt.12335
   Roza JM, 2007, ALTERN THER HEALTH M, V13, P44
   Saibandith B, 2017, MOLECULES, V22, DOI 10.3390/molecules22071082
   Saleem MMNM, 2011, AFR J BIOTECHNOL, V10, DOI 10.5897/AJB11.1399
   Sánchez JLG, 2002, EUR J ENDOCRINOL, V147, P495, DOI 10.1530/eje.0.1470495
   Sauder KA, 2015, METABOLISM, V64, P1521, DOI 10.1016/j.metabol.2015.07.021
   Servili M, 2014, ANTIOXIDANTS-BASEL, V3, P1, DOI 10.3390/antiox3010001
   Shabani E, 2019, PRIM CARE DIABETES, V13, P28, DOI 10.1016/j.pcd.2018.07.007
   Shafiee M, 2017, J AGR FOOD CHEM, V65, P10837, DOI 10.1021/acs.jafc.7b03762
   Shen W, 2013, BANGL J PHARMACOL, V8, P156, DOI 10.3329/bjp.v8i2.14240
   Sheng L, 2006, EUR J PHARMACOL, V543, P116, DOI 10.1016/j.ejphar.2006.05.038
   Sil R, 2015, MOL CELL BIOCHEM, V409, P177, DOI 10.1007/s11010-015-2523-y
   Silva S, 2006, FOOD SCI TECHNOL INT, V12, P385, DOI 10.1177/1082013206070166
   Siri-Tarino PW, 2015, ANNU REV NUTR, V35, P517, DOI 10.1146/annurev-nutr-071714-034449
   Sommella E, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010163
   Srinivasan P, 2018, J PHARM ANAL, V8, P109, DOI 10.1016/j.jpha.2017.10.005
   STLEGER AS, 1979, LANCET, V1, P1017, DOI 10.1016/S0140-6736(79)92765-X
   Stohs SJ, 2012, INT J MED SCI, V9, P527, DOI 10.7150/ijms.4446
   Storniolo C.E., Eur.
   Sun F, 2016, NUTRIENTS, V8, DOI 10.3390/nu8050174
   Susalit E, 2011, PHYTOMEDICINE, V18, P251, DOI 10.1016/j.phymed.2010.08.016
   Takahashi T, 2009, BIOCHEM BIOPH RES CO, V382, P549, DOI 10.1016/j.bbrc.2009.03.059
   Tariq H, 2016, GASTROENTEROL RES, V9, P87, DOI 10.14740/gr731w
   Tarozzi A, 2006, EUR J NUTR, V45, P152, DOI 10.1007/s00394-005-0575-6
   Tenore GC, 2018, PHARMANUTRITION, V6, P85, DOI 10.1016/j.phanu.2018.05.001
   Tenore GC, 2017, J SCI FOOD AGR, V97, P2107, DOI 10.1002/jsfa.8016
   Tenore GC, 2017, J MED FOOD, V20, P288, DOI 10.1089/jmf.2016.0152
   Tenore GC, 2014, FOOD RES INT, V63, P252, DOI 10.1016/j.foodres.2014.05.024
   Tenore GC, 2013, FOOD CHEM, V141, P3519, DOI 10.1016/j.foodchem.2013.06.051
   Teshika JD, 2019, CRIT REV FOOD SCI, V59, pS39, DOI 10.1080/10408398.2018.1499074
   Thandapilly SJ, 2013, HYPERTENS RES, V36, P866, DOI 10.1038/hr.2013.55
   Tian Hui, 2006, Zhong Yao Cai, V29, P920
   Trepiana J, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19113473
   Trigueros L, 2013, CRIT REV FOOD SCI, V53, P929, DOI 10.1080/10408398.2011.574215
   Tripoli E, 2005, NUTR RES REV, V18, P98, DOI 10.1079/NRR200495
   Trovato A, 1996, PHYTOMEDICINE, V2, P221, DOI 10.1016/S0944-7113(96)80046-8
   Trovato A, 2010, PHYTOTHER RES, V24, P514, DOI 10.1002/ptr.2971
   Tundis R, 2011, PLANT FOOD HUM NUTR, V66, P261, DOI 10.1007/s11130-011-0248-y
   Ueshima K, 2004, EUR J PHARMACOL, V501, P137, DOI 10.1016/j.ejphar.2004.08.014
   Um JH, 2010, DIABETES, V59, P554, DOI 10.2337/db09-0482
   Vaidya HB, 2013, J PHARM PHARM SCI, V16, P530, DOI 10.18433/J3FS4F
   Valentová K, 2007, J AGR FOOD CHEM, V55, P7726, DOI 10.1021/jf0712447
   Valls RM, 2015, FOOD CHEM, V167, P30, DOI 10.1016/j.foodchem.2014.06.107
   Villarroya F, 2017, NAT REV ENDOCRINOL, V13, P26, DOI 10.1038/nrendo.2016.136
   Visioli F, 1998, J AGR FOOD CHEM, V46, P4292, DOI 10.1021/jf980049c
   Vlavcheski F, 2017, MOLECULES, V22, DOI 10.3390/molecules22101669
   Vossen P, 2007, HORTSCIENCE, V42, P1093, DOI 10.21273/HORTSCI.42.5.1093
   Wainstein J, 2012, J MED FOOD, V15, P605, DOI 10.1089/jmf.2011.0243
   Wang Q, 2015, J PHARMACEUT BIOMED, V115, P515, DOI 10.1016/j.jpba.2015.08.013
   Wang X, 2014, FOOD HYDROCOLLOID, V38, P129, DOI 10.1016/j.foodhyd.2013.12.003
   Wang YG, 2012, CHEM-BIOL INTERACT, V200, P11, DOI 10.1016/j.cbi.2012.08.023
   WITZTUM JL, 1991, J CLIN INVEST, V88, P1785, DOI 10.1172/JCI115499
   Woo HM, 2007, LIFE SCI, V80, P926, DOI 10.1016/j.lfs.2006.11.030
   Wu SC, 2009, J AGR FOOD CHEM, V57, P5610, DOI 10.1021/jf9010388
   Medina FX, 2009, PUBLIC HEALTH NUTR, V12, P1618, DOI 10.1017/S1368980009990450
   Xi L, 2007, J NUTR BIOCHEM, V18, P64, DOI 10.1016/j.jnutbio.2006.03.010
   Xie PJ, 2015, J FUNCT FOODS, V16, P460, DOI 10.1016/j.jff.2015.05.005
   Xu SQ, 1999, J NUTR BIOCHEM, V10, P654, DOI 10.1016/S0955-2863(99)00056-X
   Yang F, 2017, PROTEIN CELL, V8, P169, DOI 10.1007/s13238-016-0353-7
   Yang R, 2015, PLANTA MED, V81, P1654, DOI 10.1055/s-0035-1557893
   Yi LZ, 2017, PHYTOCHEM REV, V16, P479, DOI 10.1007/s11101-017-9497-1
   Yoshino F, 2011, J CLIN BIOCHEM NUTR, V49, P182, DOI 10.3164/jcbn.11-01
   Yu YM, 2008, BRIT J NUTR, V100, P731, DOI 10.1017/S0007114508923710
   Yu YM, 2009, EUR J NUTR, V48, P101, DOI 10.1007/s00394-008-0768-x
   Yun YS, 2013, PHYTOTHER RES, V27, P906, DOI 10.1002/ptr.4794
   Zhang HL, 2008, BIOORG MED CHEM LETT, V18, P3272, DOI 10.1016/j.bmcl.2008.04.052
   Zhang LL, 2007, CIRC RES, V100, P1063, DOI 10.1161/01.RES.0000262653.84850.8b
   Zheng J, 2017, BIOSCIENCE REP, V37, DOI 10.1042/BSR20170286
   Zygmunt K, 2010, BIOCHEM BIOPH RES CO, V398, P178, DOI 10.1016/j.bbrc.2010.06.048
NR 286
TC 68
Z9 70
U1 2
U2 44
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0223-5234
EI 1768-3254
J9 EUR J MED CHEM
JI Eur. J. Med. Chem.
PD JAN 15
PY 2020
VL 186
AR 111903
DI 10.1016/j.ejmech.2019.111903
PG 30
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA KG0FJ
UT WOS:000509616800042
PM 31787360
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Dasuri, K
   Zhang, L
   Kim, SOKF
   Bruce-Keller, AJ
   Keller, JN
AF Dasuri, Kalavathi
   Zhang, Le
   Kim, Sun O. K. Fernandez
   Bruce-Keller, Annadora J.
   Keller, Jeffrey N.
TI Dietary and donepezil modulation of mTOR signaling and neuroinflammation
   in the brain
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Article
DE Brain; Aging; High fat diet; Obesity; Neurodegenerative disorders; mTOR
   pathway; Donepezil; Neuroinflammation
ID HIGH-FAT-DIET; INDUCED INSULIN-RESISTANCE; TAUOPATHY MOUSE MODEL;
   ALZHEIMERS-DISEASE; MAMMALIAN TARGET; ADIPOSE-TISSUE; GLUTAMATE
   NEUROTOXICITY; COGNITIVE IMPAIRMENT; METABOLIC SYNDROME; OXIDATIVE
   STRESS
AB Recent clinical and laboratory evidences suggest that high fat diet (HFD) induced obesity and its associated metabolic syndrome conditions promotes neuropathology in aging and age-related neurological disorders. However, the effects of high fat diet on brain pathology are poorly understood, and the effective strategies to overcome these effects remain elusive. In the current study, we examined the effects of HFD on brain pathology and further evaluated whether donepezil, an AChE inhibitor with neuroprotective functions, could suppress the ongoing HFD induced pathological changes in the brain.
   Our data demonstrates that HFD induced obesity results in increased neuroinflammation and increased AChE activity in the brain when compared with the mice fed on low fat diet (LFD). HFD administration to mice activated mTOR pathway resulting in increased phosphorylation of mTORser2448, AKTthr3 8 and S6K proteins involved in the signaling. Interestingly, donepezil administration with HFD suppressed HFD induced increases in AChE activity, and partially reversed HFD effects on microglial reactivity and the levels of mTOR signaling proteins in the brain when compared to the mice on LFD alone. However, gross levels of synaptic proteins were not altered in the brain tissues of mice fed either diet with or without donepezil. In conclusion, these results present a new insight into the detrimental effects of HFD on brain via microglial activation and involvement of mTOR pathway, and further demonstrates the possible therapeutic role for donepezil in ameliorating the early effects of HFD that could help preserve the brain function in metabolic syndrome conditions. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Dasuri, Kalavathi; Zhang, Le; Kim, Sun O. K. Fernandez; Bruce-Keller, Annadora J.; Keller, Jeffrey N.] LSU Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70810 USA.
   [Dasuri, Kalavathi] Tufts Univ, USDA, Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
   [Zhang, Le] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Geriatr, Inst Aging, Wuhan 430074, Peoples R China.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center; Tufts University; United States
   Department of Agriculture (USDA); Huazhong University of Science &
   Technology
RP Dasuri, K (corresponding author), LSU Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70810 USA.; Dasuri, K (corresponding author), Tufts Univ, USDA, Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
EM Kalavathidasuri@gmail.com
RI DASURI, KALAVATHI/E-7381-2012; Bruce-Keller, Annadora/N-1954-2017;
   Keller, Jeffrey/N-1975-2017
OI keller, jeffrey/0000-0002-9892-7423
FU COBRE from the National Institutes of Health [NIH 2P20-RR021945]; NORC
   from the National Institutes of Health [NIH 2P30-DK072476]; Pennington
   Animal Metabolism and Behavior Core; NIH; Hibernia National Bank/Edward
   G Schleider Chair
FX This work used the facilities of the Cell Biology and Bioimaging Core
   which are supported in part by COBRE (NIH 2P20-RR021945) and NORC (NIH
   2P30-DK072476) center grants from the National Institutes of Health, the
   Pennington Animal Metabolism and Behavior Core. The work was supported
   by funds from the NIH and Hibernia National Bank/Edward G Schleider
   Chair to JNK.
CR An WL, 2003, AM J PATHOL, V163, P591, DOI 10.1016/S0002-9440(10)63687-5
   Bartolini M, 2003, BIOCHEM PHARMACOL, V65, P407, DOI 10.1016/S0006-2952(02)01514-9
   Beydoun MA, 2008, OBES REV, V9, P204, DOI 10.1111/j.1467-789X.2008.00473.x
   Bruce-Keller AJ, 2011, NEUROBIOL DIS, V44, P317, DOI 10.1016/j.nbd.2011.07.012
   Buckman LB, 2013, J COMP NEUROL, V521, P1322, DOI 10.1002/cne.23233
   Caccamo A, 2010, J BIOL CHEM, V285, P13107, DOI 10.1074/jbc.M110.100420
   Cai DS, 2012, AGING-US, V4, P98, DOI 10.18632/aging.100431
   Cancello R, 2006, BJOG-INT J OBSTET GY, V113, P1141, DOI 10.1111/j.1471-0528.2006.01004.x
   Catalán V, 2015, ACTA DIABETOL, V52, P257, DOI 10.1007/s00592-014-0632-9
   Chiang GG, 2005, J BIOL CHEM, V280, P25485, DOI 10.1074/jbc.M501707200
   Davidson TL, 2013, NEUROSCIENCE, V253, P110, DOI 10.1016/j.neuroscience.2013.08.044
   De Souza CT, 2005, ENDOCRINOLOGY, V146, P4192, DOI 10.1210/en.2004-1520
   Dello Russo C, 2009, BIOCHEM PHARMACOL, V78, P1242, DOI 10.1016/j.bcp.2009.06.097
   Dong HX, 2009, BRAIN RES, V1303, P169, DOI 10.1016/j.brainres.2009.09.097
   Feldman H, 2001, NEUROLOGY, V57, P613, DOI 10.1212/WNL.57.4.613
   Freeman LR, 2014, NUTR NEUROSCI, V17, P241, DOI 10.1179/1476830513Y.0000000092
   Freeman LR, 2013, FREE RADICAL BIO MED, V56, P226, DOI 10.1016/j.freeradbiomed.2012.08.577
   Freeman LR, 2012, J CEREBR BLOOD F MET, V32, P643, DOI 10.1038/jcbfm.2011.168
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Giacobini E, 2000, ANN NY ACAD SCI, V920, P321
   Gkogkas Christos G, 2013, Cell Logist, V3, pe24551
   Graber TE, 2013, LEARN MEMORY, V20, P518, DOI 10.1101/lm.027664.112
   Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
   Gupta S, 2012, ANTIVIR RES, V95, P19, DOI 10.1016/j.antiviral.2012.04.010
   Hoeffer CA, 2010, TRENDS NEUROSCI, V33, P67, DOI 10.1016/j.tins.2009.11.003
   Jung CH, 2010, FEBS LETT, V584, P1287, DOI 10.1016/j.febslet.2010.01.017
   Kim HG, 2014, NEUROTOXICOLOGY, V40, P23, DOI 10.1016/j.neuro.2013.10.004
   Laplante M, 2012, CELL, V149, P274, DOI 10.1016/j.cell.2012.03.017
   Laplante M, 2009, J CELL SCI, V122, P3589, DOI 10.1242/jcs.051011
   Lee CH, 2015, CLIN ENDOCRINOL, V83, P147, DOI 10.1111/cen.12667
   Li X, 2005, FEBS J, V272, P4211, DOI 10.1111/j.1742-4658.2005.04833.x
   Meunier J, 2006, BRIT J PHARMACOL, V149, P998, DOI 10.1038/sj.bjp.0706927
   Orr ME, 2014, NEUROBIOL AGING, V35, P1233, DOI 10.1016/j.neurobiolaging.2013.12.006
   Park J, 2012, J CEREBR BLOOD F MET, V32, P330, DOI 10.1038/jcbfm.2011.131
   Pepping JK, 2013, AM J PHYSIOL-ENDOC M, V304, pE392, DOI 10.1152/ajpendo.00398.2012
   Perluigi M., 2015, Neurobiology of disease
   Puig KL, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030378
   Rahmouni K, 2005, HYPERTENSION, V45, P9, DOI 10.1161/01.HYP.0000151325.83008.b4
   Saha AK, 2011, CELL CYCLE, V10, P3447, DOI 10.4161/cc.10.20.17886
   Saxena G, 2008, EUR J PHARMACOL, V581, P283, DOI 10.1016/j.ejphar.2007.12.009
   Stemmer K, 2012, DIS MODEL MECH, V5, P627, DOI 10.1242/dmm.009407
   Stranahan AM, 2008, HIPPOCAMPUS, V18, P1085, DOI 10.1002/hipo.20470
   Strissel KJ, 2007, DIABETES, V56, P2910, DOI 10.2337/db07-0767
   Takada Y, 2003, J PHARMACOL EXP THER, V306, P772, DOI 10.1124/jpet.103.050104
   Takada-Takatori Y, 2006, NEUROPHARMACOLOGY, V51, P474, DOI 10.1016/j.neuropharm.2006.04.007
   Tang Z, 2015, BBA-MOL CELL RES, V1853, P1646, DOI 10.1016/j.bbamcr.2015.03.003
   Thaler JP, 2012, J CLIN INVEST, V122, P153, DOI 10.1172/JCI59660
   Tramutola A, 2015, J NEUROCHEM, V133, P739, DOI 10.1111/jnc.13037
   Tremblay F, 2007, P NATL ACAD SCI USA, V104, P14056, DOI 10.1073/pnas.0706517104
   Valdearcos M, 2014, CELL REP, V9, P2124, DOI 10.1016/j.celrep.2014.11.018
   Walker GE, 2014, HORM MOL BIOL CLIN I, V19, P57, DOI 10.1515/hmbci-2014-0023
   Weatherill DB, 2010, J BIOL CHEM, V285, P12255, DOI 10.1074/jbc.M109.071142
   Weichhart T, 2011, BLOOD, V117, P4273, DOI 10.1182/blood-2010-09-310888
   Wilkinson DG, 2004, DRUG AGING, V21, P453, DOI 10.2165/00002512-200421070-00004
   Yoshiyama Y, 2007, NEURON, V53, P337, DOI 10.1016/j.neuron.2007.01.010
   Yoshiyama Y, 2010, J ALZHEIMERS DIS, V22, P295, DOI 10.3233/JAD-2010-100681
   Zhang L, 2013, BBA-MOL BASIS DIS, V1832, P1456, DOI 10.1016/j.bbadis.2013.01.002
NR 57
TC 24
Z9 24
U1 0
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 0006-3002
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD FEB
PY 2016
VL 1862
IS 2
BP 274
EP 283
DI 10.1016/j.bbadis.2015.11.002
PG 10
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA DN9SH
UT WOS:000377420500014
PM 26554604
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Mahli, A
   Hellerbrand, C
AF Mahli, Abdo
   Hellerbrand, Claus
TI Alcohol and Obesity: A Dangerous Association for Fatty Liver Disease
SO DIGESTIVE DISEASES
LA English
DT Article
DE Alcoholic liver disease; Nonalcoholic fatty liver disease; Metabolic
   syndrome; Obesity; Synergism
ID ENDOPLASMIC-RETICULUM STRESS; HEPATIC STELLATE CELLS; BODY-MASS INDEX;
   HEPATOCELLULAR-CARCINOMA; LIPID-ACCUMULATION; RISK-FACTORS; DECREASED
   PREVALENCE; NATURAL-HISTORY; CONSUMPTION; ETHANOL
AB Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are the most frequent chronic liver disorders, and their advanced forms - alcoholic steatohepatitis and nonalcoholic steatohepatitis - are the most frequent conditions leading to liver cirrhosis and hepatocellular carcinoma worldwide. NAFLD is considered as the hepatic manifestation of the metabolic syndrome. With the pandemic rise of obesity, the incidence of NAFLD is also further increasing, and considering the life style in modern societies, there is a significant overlap of (risk factors causing) NAFLD and (alcohol consumption predisposing for) ALD at least in Western countries. Epidemiological studies propose a causative link between chronic alcohol consumption and progressive liver disease in obese individuals. Furthermore, experimental studies indicate combined pathological effects of alcohol and obesity or fatty acid levels, respectively, on hepatocellular lipid accumulation and injury as well as hepatic inflammation, fibrosis and cancerogenesis. Notably, these combined pathological effects are in part additive but partly even synergistic. And importantly, alcohol does already exhibit synergistic pathological effects with obesity at moderate doses. This indicates significant differences in the dose threshold for hepatotoxic alcohol effects in lean and obese subjects and herewith also has important implications for recommendations for 'safe' alcohol consumption. The purpose of this brief review is to update the knowledge on the combined effects of alcohol and obesity on the development and progression of liver disease. Undoubtedly, alcohol and the metabolic syndrome appear as a dangerous mix, and there are important interactive effects of either condition with regard to crucial triggers of liver injury. (C) 2016 S. Karger AG, Basel
C1 [Mahli, Abdo; Hellerbrand, Claus] Univ Hosp Regensburg, Dept Internal Med 1, DE-3053 Regensburg, Germany.
C3 University of Regensburg
RP Hellerbrand, C (corresponding author), Univ Hosp Regensburg, Dept Internal Med 1, DE-3053 Regensburg, Germany.
EM claus.hellerbrand@ukr.de
RI Mahli, Abdo/AAD-4744-2019
OI Mahli, Abdo/0000-0002-8333-7551
CR Ajmo JM, 2008, AM J PHYSIOL-GASTR L, V295, pG833, DOI 10.1152/ajpgi.90358.2008
   Alatalo PI, 2008, AM J CLIN NUTR, V88, P1097, DOI 10.1093/ajcn/88.4.1097
   Ascha MS, 2010, HEPATOLOGY, V51, P1972, DOI 10.1002/hep.23527
   Assy N, 2008, CAN J GASTROENTEROL, V22, P811, DOI 10.1155/2008/810961
   Baur JA, 2006, NAT REV DRUG DISCOV, V5, P493, DOI 10.1038/nrd2060
   Becker U, 2002, HEPATOLOGY, V35, P868, DOI 10.1053/jhep.2002.32101
   Bellentani S, 2000, ANN INTERN MED, V132, P112, DOI 10.7326/0003-4819-132-2-200001180-00004
   Bergheim I, 2003, EUR J CLIN NUTR, V57, P431, DOI 10.1038/sj.ejcn.1601557
   Bergheim I, 2008, J HEPATOL, V48, P983, DOI 10.1016/j.jhep.2008.01.035
   Buettner R, 2006, J MOL ENDOCRINOL, V36, P485, DOI 10.1677/jme.1.01909
   Bujanda L, 2006, BMC GASTROENTEROL, V6, DOI 10.1186/1471-230X-6-35
   Carmiel-Haggai M, 2003, GASTROENTEROLOGY, V125, P1818, DOI 10.1053/j.gastro.2003.09.019
   Chen SH, 2014, J GASTROEN HEPATOL, V29, P435, DOI 10.1111/jgh.12422
   Cimino L, 2001, DIGEST LIVER DIS, V33, P240, DOI 10.1016/S1590-8658(01)80714-3
   Clark JM, 2003, AM J GASTROENTEROL, V98, P960, DOI [10.1016/S0002-9270(03)00265-X, 10.1111/j.1572-0241.2003.07486.x]
   Czaja MJ, 2010, AM J PHYSIOL-CELL PH, V298, pC973, DOI 10.1152/ajpcell.00527.2009
   Ding WX, 2010, GASTROENTEROLOGY, V139, P1740, DOI 10.1053/j.gastro.2010.07.041
   Dunn W, 2008, HEPATOLOGY, V47, P1947, DOI 10.1002/hep.22292
   Dunn W, 2012, J HEPATOL, V57, P384, DOI 10.1016/j.jhep.2012.03.024
   Ekstedt M, 2009, SCAND J GASTROENTERO, V44, P366, DOI 10.1080/00365520802555991
   Falck-Ytter Y, 2001, SEMIN LIVER DIS, V21, P17, DOI 10.1055/s-2001-12926
   Feldstein AE, 2003, J HEPATOL, V39, P978, DOI 10.1016/S0168-8278(03)00460-4
   Finelli C, 2013, WORLD J GASTROENTERO, V19, P802, DOI 10.3748/wjg.v19.i6.802
   Gäbele E, 2011, ALCOHOL CLIN EXP RES, V35, P1361, DOI 10.1111/j.1530-0277.2011.01472.x
   Galli A, 1999, HEPATOLOGY, V29, P1164, DOI 10.1002/hep.510290420
   Gebhardt AC, 1997, HEPATOLOGY, V26, P957, DOI 10.1053/jhep.1997.v26.pm0009328319
   Gentile CL, 2008, J NUTR BIOCHEM, V19, P567, DOI 10.1016/j.jnutbio.2007.10.001
   González-Rodríguez A, 2014, CELL DEATH DIS, V5, DOI 10.1038/cddis.2014.162
   Gunji T, 2009, AM J GASTROENTEROL, V104, P2189, DOI 10.1038/ajg.2009.361
   Hansel B, 2015, EUR J PREV CARDIOL, V22, P215, DOI 10.1177/2047487313506829
   Hellerbrand C, 2010, DIGEST DIS, V28, P783, DOI 10.1159/000324286
   Heyerick A, 2003, PHOTOCH PHOTOBIO SCI, V2, P306, DOI 10.1039/b210935b
   Homann N, 2009, ALCOHOL CLIN EXP RES, V33, P551, DOI 10.1111/j.1530-0277.2008.00868.x
   Hourigan LF, 1999, HEPATOLOGY, V29, P1215, DOI 10.1002/hep.510290401
   Kanuri G, 2015, EUR J NUTR, V54, P465, DOI 10.1007/s00394-014-0730-z
   Kasdallah-Grissa A, 2006, ALCOHOL ALCOHOLISM, V41, P236, DOI 10.1093/alcalc/agh256
   Kusminski CM, 2009, APOPTOSIS, V14, P1484, DOI 10.1007/s10495-009-0352-8
   Lederer SL, 2006, VIROL J, V3, DOI 10.1186/1743-422X-3-98
   LIEBER CS, 1961, J CLIN INVEST, V40, P394, DOI 10.1172/JCI104266
   Lin CW, 2013, J HEPATOL, V58, P993, DOI 10.1016/j.jhep.2013.01.011
   Liu B, 2010, BMJ-BRIT MED J, V340, DOI 10.1136/bmj.c912
   Liu F, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0142457
   Loomba R, 2009, ALIMENT PHARM THER, V30, P1137, DOI 10.1111/j.1365-2036.2009.04141.x
   Loomba R, 2013, AM J EPIDEMIOL, V177, P333, DOI 10.1093/aje/kws252
   Mahli A, 2015, ONCOTARGET, V6, P41464, DOI 10.18632/oncotarget.6203
   Mathurin P, 2012, J HEPATOL, V57, P399, DOI 10.1016/j.jhep.2012.04.004
   Moriya A, 2011, ALIMENT PHARM THER, V33, P378, DOI 10.1111/j.1365-2036.2010.04520.x
   Mueller S, 2009, WORLD J GASTROENTERO, V15, P3462, DOI 10.3748/wjg.15.3462
   NANJI AA, 1985, LANCET, V1, P681
   NANJI AA, 1989, ALCOHOL CLIN EXP RES, V13, P15, DOI 10.1111/j.1530-0277.1989.tb00276.x
   Naveau S, 1997, HEPATOLOGY, V25, P108, DOI 10.1002/hep.510250120
   O'Shea RS, 2010, HEPATOLOGY, V51, P307, DOI 10.1002/hep.23258
   Obara K, 2009, CLIN NUTR, V28, P278, DOI 10.1016/j.clnu.2009.03.012
   Purohit V, 2009, ALCOHOL CLIN EXP RES, V33, P191, DOI 10.1111/j.1530-0277.2008.00827.x
   Rajkovic N, 2014, INT J ENV RES PUB HE, V11, P4049, DOI 10.3390/ijerph110404049
   Ramaiah SK, 2004, INT J TOXICOL, V23, P217, DOI 10.1080/10915810490502069
   Raynard B, 2002, HEPATOLOGY, V35, P635, DOI 10.1053/jhep.2002.31782
   Rinella ME, 2015, JAMA-J AM MED ASSOC, V313, P2263, DOI 10.1001/jama.2015.5370
   Rogers CQ, 2008, IUBMB LIFE, V60, P790, DOI 10.1002/iub.124
   Rozman D, 2014, DIGEST DIS SCI, V59, P238, DOI 10.1007/s10620-013-2998-x
   Ruhl CE, 2005, CLIN GASTROENTEROL H, V3, P1260, DOI 10.1016/S1542-3565(05)00743-3
   Saxena NK, 2004, FASEB J, V18, P1612, DOI 10.1096/fj.04-1847fje
   Seitz HK, 2012, BREAST, V21, P426, DOI 10.1016/j.breast.2012.01.017
   Singh R, 2009, NATURE, V458, P1131, DOI 10.1038/nature07976
   Sookoian S, 2014, GUT, V63, P530, DOI 10.1136/gutjnl-2013-305718
   Swaminathan K, 2013, LIFE SCI, V92, P325, DOI 10.1016/j.lfs.2012.12.014
   Szabo G, 2015, GASTROENTEROLOGY, V148, P30, DOI 10.1053/j.gastro.2014.10.042
   Teli MR, 1995, HEPATOLOGY, V22, P1714, DOI 10.1016/0270-9139(95)90196-5
   Tipoe GL, 2009, HISTOL HISTOPATHOL, V24, P1161, DOI 10.14670/HH-24.1161
   Wang D, 2006, ENDOCRINOLOGY, V147, P943, DOI 10.1210/en.2005-0570
   Wang Y, 2010, ALCOHOL CLIN EXP RES, V34, P567, DOI 10.1111/j.1530-0277.2009.01122.x
   Wang Y, 2009, HEPATOLOGY, V50, P453, DOI 10.1002/hep.22978
   Wang Y, 2009, ARQ BRAS ENDOCRINOL, V53, P201, DOI 10.1590/S0004-27302009000200012
   Wannamethee SG, 2003, ARCH INTERN MED, V163, P1329, DOI 10.1001/archinte.163.11.1329
   Weiskirchen R, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00140
   Wobser H, 2009, CELL RES, V19, P996, DOI 10.1038/cr.2009.73
   Wu DF, 2010, BIOCHEM BIOPH RES CO, V402, P116, DOI 10.1016/j.bbrc.2010.09.127
   Xu J, 2011, J HEPATOL, V55, P673, DOI 10.1016/j.jhep.2010.12.034
   Yan AW, 2012, WORLD J HEPATOL, V4, P110, DOI 10.4254/wjh.v4.i4.110
NR 79
TC 49
Z9 51
U1 1
U2 13
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0257-2753
EI 1421-9875
J9 DIGEST DIS
JI Dig. Dis.
PY 2016
VL 34
SU 1
BP 32
EP 39
DI 10.1159/000447279
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA DU0HA
UT WOS:000381882000006
PM 27548267
OA Green Published
DA 2025-06-11
ER

PT J
AU Siervo, M
   Harrison, SL
   Jagger, C
   Robinson, L
   Stephan, BCM
AF Siervo, Mario
   Harrison, Stephanie L.
   Jagger, Carol
   Robinson, Louise
   Stephan, Blossom C. M.
TI Metabolic Syndrome and Longitudinal Changes in Cognitive Function: A
   Systematic Review and Meta-Analysis
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Aging; cognition; cohort studies; metabolic syndrome; risk prediction;
   systematic review
ID VASCULAR RISK-FACTORS; ALZHEIMERS-DISEASE; INSULIN-RESISTANCE;
   NEUROPSYCHOLOGICAL TESTS; DIABETES-MELLITUS; OXIDATIVE STRESS; DECLINE;
   DEMENTIA; POPULATION; IMPAIRMENT
AB Background: Metabolic syndrome (MetS) is associated with an increased risk of coronary heart diseases and stroke. Results on the association of MetS with dementia and cognitive decline have been inconsistent.
   Objective: The aim of this study was to examine the association between MetS and longitudinal changes in cognitive function.
   Methods: Medline, EMBASE, and Scopus databases were searched from inception to June 2013. Longitudinal cohort studies that reported on the association between MetS and change in cognitive function (over two or more time points), were included.
   Results: Random-effects models were used to assess the pooled effect sizes of longitudinal changes in cognitive function associated with MetS. Thirteen studies were included. The total sample size was 19,522 subjects. Followup duration ranged from 1 to 16 years. In the total sample, a small association of MetS with cognitive decline was observed (SDM 0.06, 95% CI: -0.001, 0.12; p = 0.05). When age-stratified, a marginal significant association between MetS and cognitive decline was observed in the younger old group (<= 70 years; SDM=0.09, 95% CI: -0.003, 0.19; p = 0.05) but not in the older group (> 70 years; SDM=0.03, 95% CI: -0.05, 0.11; p = 0.48). The meta-regression showed that duration of follow up was not associated with changes in cognitive estimates (beta = 0.005; p = 0.30).
   Conclusions: Age appears to modify the association between MetS and cognitive decline. These results emphasize the importance of age-stratified risk prediction models of dementia in subjects with chronic metabolic disorders.
C1 [Siervo, Mario; Harrison, Stephanie L.; Jagger, Carol] Newcastle Univ, Inst Ageing & Hlth, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England.
   [Robinson, Louise; Stephan, Blossom C. M.] Newcastle Univ, Inst Hlth & Soc, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England.
C3 Newcastle University - UK; Newcastle University - UK
RP Siervo, M (corresponding author), Newcastle Univ, Inst Ageing & Hlth, Campus Ageing & Vital, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England.
EM mario.siervo@newcastle.ac.uk
RI Siervo, Mario/AAB-9302-2019; Stephan, Blossom/A-1560-2009
OI Robinson, Louise/0000-0003-0209-2503; Harrison,
   Stephanie/0000-0002-8846-0946; Jagger, Carol/0000-0002-6377-9926;
   Siervo, Mario/0000-0001-5515-0944
FU MRC [MR/J50001X/1, G0500997] Funding Source: UKRI
CR Abbatecola AM, 2004, J AM GERIATR SOC, V52, P1713, DOI 10.1111/j.1532-5415.2004.52466.x
   Akbaraly TN, 2010, DIABETES CARE, V33, P84, DOI 10.2337/dc09-1218
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   [Anonymous], 2001, Practical meta-analysis effect size calculator
   Azumi H, 2002, ARTERIOSCL THROM VAS, V22, P1838, DOI 10.1161/01.ATV.0000037101.40667.62
   Barzilay JI, 2011, METAB SYNDR RELAT D, V9, P327, DOI 10.1089/met.2011.0027
   Biessels GJ, 2006, LANCET NEUROL, V5, P64, DOI 10.1016/S1474-4422(05)70284-2
   Bingham EM, 2002, DIABETES, V51, P3384, DOI 10.2337/diabetes.51.12.3384
   Borenstein M, 2009, Introduction to meta-analysis, P421
   Cavalier M, 2010, DIABETES CARE, V33, P2489, DOI 10.2337/dc10-0851
   Chen HJ, 2006, STROKE, V37, P1060, DOI 10.1161/01.STR.0000206458.58142.f3
   Chrissobolis S, 2008, TRENDS MOL MED, V14, P495, DOI 10.1016/j.molmed.2008.09.003
   Crichton GE, 2012, J ALZHEIMERS DIS, V30, pS77, DOI 10.3233/JAD-2011-111022
   DERSIMONIAN R, 1986, CONTROL CLIN TRIALS, V7, P177, DOI 10.1016/0197-2456(86)90046-2
   Elias MF, 2000, ARCH NEUROL-CHICAGO, V57, P808, DOI 10.1001/archneur.57.6.808
   Folli F, 2011, CURR DIABETES REV, V7, P313, DOI 10.2174/157339911797415585
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   Frisardi V, 2010, AGEING RES REV, V9, P399, DOI 10.1016/j.arr.2010.04.007
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Hao ZL, 2011, ACTA NEUROPSYCHIATR, V23, P69, DOI 10.1111/j.1601-5215.2011.00527.x
   Higgins JPT, 2003, BMJ-BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557
   Ho RCM, 2008, AM J GERIAT PSYCHIAT, V16, P519, DOI 10.1097/JGP.0b013e31816b7841
   Katsumata Y, 2012, J GERONTOL A-BIOL, V67, P126, DOI 10.1093/gerona/glr189
   Kloppenborg RP, 2008, EUR J PHARMACOL, V585, P97, DOI 10.1016/j.ejphar.2008.02.049
   Knopman DS, 2009, ALZHEIMERS DEMENT, V5, P207, DOI 10.1016/j.jalz.2009.01.027
   Komulainen P, 2007, DEMENT GERIATR COGN, V23, P29, DOI 10.1159/000096636
   Lassègue B, 2010, ARTERIOSCL THROM VAS, V30, P653, DOI 10.1161/ATVBAHA.108.181610
   Le Couteur DG, 2011, J GERONTOL A-BIOL, V66, P179, DOI 10.1093/gerona/glq171
   Lee KS, 2010, GERONTOLOGY, V56, P32, DOI 10.1159/000236028
   Liu CL, 2013, J NUTR HEALTH AGING, V17, P523, DOI 10.1007/s12603-013-0010-2
   Liu CY, 2009, EUR J NEUROL, V16, P1022, DOI 10.1111/j.1468-1331.2009.02640.x
   Lobo A, 2000, NEUROLOGY, V54, pS4
   Luo L, 2013, J AM MED DIR ASSOC, V14, P105, DOI 10.1016/j.jamda.2012.10.001
   McEvoy LK, 2012, ANN EPIDEMIOL, V22, P310, DOI 10.1016/j.annepidem.2011.12.003
   Meshkani R, 2009, CLIN BIOCHEM, V42, P1331, DOI 10.1016/j.clinbiochem.2009.05.018
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Muller M, 2007, DEMENT GERIATR COGN, V24, P185, DOI 10.1159/000105927
   Muller M, 2010, NEUROEPIDEMIOLOGY, V34, P83, DOI 10.1159/000264825
   Panza F, 2011, CURR ALZHEIMER RES, V8, P492, DOI 10.2174/156720511796391818
   Panza F, 2010, J ALZHEIMERS DIS, V21, P691, DOI 10.3233/JAD-2010-091669
   Raffaitin C, 2011, NEUROLOGY, V76, P518, DOI 10.1212/WNL.0b013e31820b7656
   Raffaitin C, 2009, DIABETES CARE, V32, P169, DOI 10.2337/dc08-0272
   Razay G, 2007, ARCH NEUROL-CHICAGO, V64, P93, DOI 10.1001/archneur.64.1.93
   Schmidt CO, 2008, INT J PUBLIC HEALTH, V53, P165, DOI 10.1007/s00038-008-7068-3
   Schuur M, 2010, EUR J EPIDEMIOL, V25, P561, DOI 10.1007/s10654-010-9476-y
   Segura B, 2009, NEUROSCI LETT, V462, P49, DOI 10.1016/j.neulet.2009.06.071
   Solfrizzi V, 2010, J NEUROL NEUROSUR PS, V81, P433, DOI 10.1136/jnnp.2009.181743
   Stang A, 2010, EUR J EPIDEMIOL, V25, P603, DOI 10.1007/s10654-010-9491-z
   Steen E, 2005, J ALZHEIMERS DIS, V7, P63, DOI 10.3233/jad-2005-7107
   Stephan BCM, 2007, J AM GERIATR SOC, V55, P1534, DOI 10.1111/j.1532-5415.2007.01386.x
   Tierney MC, 2010, J ALZHEIMERS DIS, V22, P1231, DOI 10.3233/JAD-2010-100516
   Tierney MC, 2005, NEUROLOGY, V64, P1853, DOI 10.1212/01.WNL.0000163773.21794.0B
   van den Berg E, 2007, NEUROLOGY, V69, P979, DOI 10.1212/01.wnl.0000271381.30143.75
   van den Berg E, 2008, DEMENT GERIATR COGN, V26, P261, DOI 10.1159/000160959
   Vieira JR, 2011, NEUROEPIDEMIOLOGY, V37, P153, DOI 10.1159/000332208
   Vischer UM, 2009, DIABETES METAB, V35, P108, DOI 10.1016/j.diabet.2008.08.006
   Viscogliosi G, 2012, METAB SYNDR RELAT D, V10, P358, DOI 10.1089/met.2012.0043
   Ward A, 2012, ALZHEIMERS DEMENT, V8, P14, DOI 10.1016/j.jalz.2011.01.002
   Watts AS, 2013, J ALZHEIMERS DIS, V35, P253, DOI 10.3233/JAD-121168
   Wimo A, 2003, ALZ DIS ASSOC DIS, V17, P63, DOI 10.1097/00002093-200304000-00002
   Xiong GL, 2006, NEUROLOGY, V67, P1586, DOI 10.1212/01.wnl.0000242730.44003.1d
   Yaffe K, 2004, JAMA-J AM MED ASSOC, V292, P2237, DOI 10.1001/jama.292.18.2237
   Yaffe K, 2007, J AM GERIATR SOC, V55, P758, DOI 10.1111/j.1532-5415.2007.01139.x
   Yates KF, 2012, ARTERIOSCL THROM VAS, V32, P2060, DOI 10.1161/ATVBAHA.112.252759
   Zhong Y, 2012, BIOMED ENVIRON SCI, V25, P8, DOI 10.3967/0895-3988.2012.01.002
NR 65
TC 93
Z9 104
U1 0
U2 18
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2014
VL 41
IS 1
BP 151
EP 161
DI 10.3233/JAD-132279
PG 11
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA AI5PH
UT WOS:000336921000011
PM 24577475
DA 2025-06-11
ER

PT J
AU Perez-Martinez, P
   Perez-Jimenez, F
   Lopez-Miranda, J
AF Perez-Martinez, Pablo
   Perez-Jimenez, Francisco
   Lopez-Miranda, Jose
TI n-3 PUFA and lipotoxicity
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
LA English
DT Review
DE n-3 PUFA; Lipotoxicity; Triglycerides; Metabolic syndrome; Lipid
   accumulation; Lipoapoptosis
ID POLYUNSATURATED FATTY-ACIDS; INSULIN-RESISTANCE; BETA-CELL;
   CARDIOVASCULAR-DISEASE; NONFASTING TRIGLYCERIDES; ENDOTHELIAL FUNCTION;
   METABOLIC SYNDROME; HEPATIC STEATOSIS; OXIDATIVE STRESS; TRANSGENIC MICE
AB Excess lipid accumulation in nonadipose tissues may occur in the setting of high levels of plasma free fatty acids or triglycerides (TGs) in a process called "lipotoxicity". Evidence from human studies and animal models suggests that lipid accumulation in the heart, skeletal muscle, pancreas, and liver play an important role in the pathogenesis of heart failure, obesity, metabolic syndrome, and type 2 diabetes mellitus (T2DM). During the past few years, several studies have shown that n-3 polyunsaturated fatty acids (PUFA) have potentially cardioprotective effects, especially in high-risk patients with dyslipidemia, and might therefore be expected to be of benefit in T2DM. Moreover, new information has demonstrated the beneficial effects of consuming n-3 PUFA in preventing the complications of lipotoxicity. n-3 PUFA dietary intake thus had positive effects on fatty liver in patients with non-alcoholic fatty liver disease (NAFLD), with an improvement in liver echotexture and a significant regression of hepatic brightness, associated with improved liver hemodynamics. The n-3 PUFA also had beneficial effects on ectopic fat accumulation inside the heart, with stabilization of cardiac myocytes and antiarrhythmic effects. On the other hand, recent data from animal models suggest that oral dosing of eicosapentaenoic acid (EPA) could contribute to protect against P-cell lipotoxicity. This review discusses the latest hypotheses regarding lipotoxicity, concentrating on the impact of the n-3 PUFA that contribute to ectopic lipid storage, affecting organ function. Further human studies are needed to test the evidence and elucidate the mechanisms involved in this process. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Perez-Martinez, Pablo; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Univ Cordoba, Lipids & Atherosclerosis Res Unit, Reina Sofia Univ Hosp, IMIBIC,Inst Salud Carlos III, E-14004 Cordoba, Spain.
C3 Instituto de Salud Carlos III; Universidad de Cordoba; Hospital
   Universitario Reina Sofia - Cordoba
RP Lopez-Miranda, J (corresponding author), Univ Cordoba, Lipids & Atherosclerosis Res Unit, Reina Sofia Univ Hosp, IMIBIC,Inst Salud Carlos III, Avda Menendez Pidal S-N, E-14004 Cordoba, Spain.
EM jlopezmir@uco.es
RI Jimenez, Francisco/AAJ-9559-2021; Lopez-Miranda, Jose/Y-8306-2019; Perez
   Martinez, Pablo/AEL-6176-2022
OI Perez-Jimenez, Francisco/0000-0001-7499-7681; Perez Jimenez,
   Francisco/0000-0001-9808-1280; Perez Martinez,
   Pablo/0000-0001-7716-8117; Lopez-Miranda, Jose/0000-0002-8844-0718
FU Consejeria de Salud; Consejeria de Innovacion; Proyecto de Investigacion
   de Excelencia; Junta de Andalucia [P06-CTS-01425]; Spanish Ministry of
   Education and Science [AGL2006-01979/ALI, AGL2009-12270/ALI]; Spanish
   Ministry of Health [CB06/03/0047]
FX Source of support: This study was supported in part by research grants
   from the Consejeria de Salud, Consejeria de Innovacion, Proyecto de
   Investigacion de Excelencia, Junta de Andalucia (P06-CTS-01425), the
   Spanish Ministry of Education and Science (AGL2006-01979/ALI,
   AGL2009-12270/ALI), and the Spanish Ministry of Health (CB06/03/0047
   (CIBER Fisiopatologia de la Obesidad y Nutricion is an initiative of
   ISCIII)).
CR Aarsetoy H, 2008, RESUSCITATION, V78, P258, DOI 10.1016/j.resuscitation.2008.04.007
   [Anonymous], STUDY CARDIOVASCULAR
   Araya J, 2004, CLIN SCI, V106, P635, DOI 10.1042/CS20030326
   Bansal S, 2007, JAMA-J AM MED ASSOC, V298, P309, DOI 10.1001/jama.298.3.309
   Bassand JP, 2007, EUR HEART J, V28, P1598, DOI 10.1093/eurheartj/ehm161
   Briaud I, 2001, DIABETES, V50, P315, DOI 10.2337/diabetes.50.2.315
   British Nutrition Foundation, 1992, UNS FATT AC NUTR PHY
   Capanni M, 2006, ALIMENT PHARM THER, V23, P1143, DOI 10.1111/j.1365-2036.2006.02885.x
   Christopher CL, 2003, INT J CARDIOL, V88, P183, DOI 10.1016/S0167-5273(02)00393-5
   Connor SL, 1997, AM J CLIN NUTR, V66, P1020
   DAS AK, 1986, INDIAN J EXP BIOL, V24, P592
   Delarue J, 2004, REPROD NUTR DEV, V44, P289, DOI 10.1051/rnd:2004033
   Demirel G, 2004, BRIT J NUTR, V91, P551, DOI 10.1079/BJN20031079
   Frayn KN, 2005, P NUTR SOC, V64, P7, DOI 10.1079/PNS2004403
   Galan P, 2003, J Nutr Health Aging, V7, P428
   Gerstein HC, 2008, AM HEART J, V155, P26, DOI 10.1016/j.ahj.2007.09.009
   Hanley AJG, 2002, DIABETES CARE, V25, P1177, DOI 10.2337/diacare.25.7.1177
   Harper CR, 2005, AM J CARDIOL, V96, P1521, DOI 10.1016/j.amjcard.2005.07.071
   Hartweg J, 2007, DIABETOLOGIA, V50, P1593, DOI 10.1007/s00125-007-0695-z
   Hartweg J, 2009, CURR OPIN LIPIDOL, V20, P30, DOI 10.1097/MOL.0b013e328321b3be
   Johansen O, 1999, ARTERIOSCL THROM VAS, V19, P1681, DOI 10.1161/01.ATV.19.7.1681
   Joseph JW, 2004, J BIOL CHEM, V279, P51049, DOI 10.1074/jbc.M409189200
   Kakkos SK, 2000, SCAND J GASTROENTERO, V35, P976, DOI 10.1080/003655200750023066
   Kankaanpää M, 2006, J CLIN ENDOCR METAB, V91, P4689, DOI 10.1210/jc.2006-0584
   Kato T, 2008, DIABETES, V57, P2382, DOI 10.2337/db06-1806
   KELLY DP, 1994, NEW ENGL J MED, V330, P913
   Le Ngoc-Anh, 2007, Curr Atheroscler Rep, V9, P110, DOI 10.1007/s11883-007-0006-7
   Leaf A, 1999, LIPIDS, V34, pS187, DOI 10.1007/BF02562284
   Lieber CS, 2004, AM J CLIN NUTR, V79, P502
   Lin JD, 2005, CELL, V120, P261, DOI 10.1016/j.cell.2004.11.043
   Lombardo YB, 2006, J NUTR BIOCHEM, V17, P1, DOI 10.1016/j.jnutbio.2005.08.002
   Lombardo YB, 2007, LIPIDS, V42, P427, DOI 10.1007/s11745-007-3039-3
   Man ZW, 1997, DIABETES, V46, P1718, DOI 10.2337/diabetes.46.11.1718
   Marchioli R, 2002, CIRCULATION, V105, P1897, DOI 10.1161/01.CIR.0000014682.14181.F2
   McGarry JD, 1999, DIABETOLOGIA, V42, P128, DOI 10.1007/s001250051130
   Neel JV, 1999, NUTR REV, V57, pS2, DOI 10.1111/j.1753-4887.1999.tb01782.x
   Nordestgaard BG, 2007, JAMA-J AM MED ASSOC, V298, P299, DOI 10.1001/jama.298.3.299
   Pighin D, 2003, J NUTR, V133, P4095, DOI 10.1093/jn/133.12.4095
   Reaven G, 2002, CIRCULATION, V106, P286, DOI 10.1161/01.CIR.0000019884.36724.D9
   RODRIGUES B, 1995, J MOL CELL CARDIOL, V27, P169, DOI 10.1016/S0022-2828(08)80016-8
   Saitoh Y, 2008, DIABETES OBES METAB, V10, P564, DOI 10.1111/j.1463-1326.2007.00749.x
   Samuel VT, 2004, J BIOL CHEM, V279, P32345, DOI 10.1074/jbc.M313478200
   Sekiya M, 2003, HEPATOLOGY, V38, P1529, DOI 10.1016/j.hep.2003.09.028
   Shimabukuro M, 1998, P NATL ACAD SCI USA, V95, P2498, DOI 10.1073/pnas.95.5.2498
   Shimano H, 1997, J CLIN INVEST, V99, P846, DOI 10.1172/JCI119248
   Smith PJ, 2009, AM J CLIN NUTR, V89, P1315, DOI 10.3945/ajcn.2008.26829
   Song BJ, 2008, J HEPATOL, V49, P262, DOI 10.1016/j.jhep.2008.04.023
   Spadaro L, 2008, DIGEST LIVER DIS, V40, P194, DOI 10.1016/j.dld.2007.10.003
   Svegliati-Baroni G, 2006, AM J PATHOL, V169, P846, DOI 10.2353/ajpath.2006.050953
   Szczepaniak LS, 2003, MAGN RESON MED, V49, P417, DOI 10.1002/mrm.10372
   Szendroedi J, 2009, CURR OPIN LIPIDOL, V20, P50, DOI 10.1097/MOL.0b013e328321b3a8
   Takahashi A, 2005, DIABETES, V54, P492, DOI 10.2337/diabetes.54.2.492
   Unger RH, 2002, ANNU REV MED, V53, P319, DOI 10.1146/annurev.med.53.082901.104057
   Unger RH, 1999, P NATL ACAD SCI USA, V96, P2327, DOI 10.1073/pnas.96.5.2327
   Unger RH, 2001, FASEB J, V15, P312, DOI 10.1096/fj.00-0590
   Videla LA, 2004, FREE RADICAL BIO MED, V37, P1499, DOI 10.1016/j.freeradbiomed.2004.06.033
   Vogel RA, 2000, CLEV CLIN J MED, V67, P232
   von Schacky C, 2004, CURR OPIN CLIN NUTR, V7, P131, DOI 10.1097/00075197-200403000-00005
   Westerbacka J, 2005, J CLIN ENDOCR METAB, V90, P2804, DOI 10.1210/jc.2004-1983
   Yahagi N, 1999, J BIOL CHEM, V274, P35840, DOI 10.1074/jbc.274.50.35840
   Zhou YT, 2000, P NATL ACAD SCI USA, V97, P1784, DOI 10.1073/pnas.97.4.1784
NR 61
TC 43
Z9 46
U1 1
U2 37
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1388-1981
EI 1879-2618
J9 BBA-MOL CELL BIOL L
JI Biochim. Biophys. Acta Mol. Cell Biol. Lipids
PD MAR
PY 2010
VL 1801
IS 3
SI SI
BP 362
EP 366
DI 10.1016/j.bbalip.2009.09.010
PG 5
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 568YT
UT WOS:000275563300020
PM 19781663
DA 2025-06-11
ER

PT J
AU Donoho, CJ
   Weigensberg, MJ
   Emken, BA
   Hsu, JW
   Spruijt-Metz, D
AF Donoho, Carrie J.
   Weigensberg, Marc J.
   Emken, B. Adar
   Hsu, Ja-Wen
   Spruijt-Metz, Donna
TI Stress and Abdominal Fat: Preliminary Evidence of Moderation by the
   Cortisol Awakening Response in Hispanic Peripubertal Girls
SO OBESITY
LA English
DT Article
ID SUBCUTANEOUS ADIPOSE-TISSUE; ADRENAL AXIS ACTIVITY; MAGNETIC-RESONANCE;
   METABOLIC SYNDROME; VISCERAL OBESITY; WHITEHALL-II; RISK; CHILDREN;
   HEALTH; WOMEN
AB Stress and the cortisol awakening response (CAR) have been independently linked to increases in abdominal fat depots. This cross-sectional study examined the CAR as a moderator of the association between stress, visceral adipose tissue (VAT), and subcutaneous abdominal adipose tissue (SAT) in a sample (N = 23) of female peripubertal Hispanic girls aged from 8 to 11. The study included: (i) monitored salivary cortisol collection, (ii) VAT and SAT obtained by multislice magnetic resonance imaging, and (iii) a stressful life events checklist with four domain-specific subscales: peer, family, personal, and school. Regression analysis indicated an interaction of school-related life events and CAR on VAT and SAT, with greater numbers of school-related events being related to greater VAT and SAT for girls with high CAR, but no association with VAT or SAT for girls with low CAR. Similar to job stress in adults, school-related stress in children may contribute to central adiposity, especially for girls with high CAR.
C1 [Donoho, Carrie J.] Univ So Calif, Davis Sch Gerontol, Los Angeles, CA 90089 USA.
   [Donoho, Carrie J.; Emken, B. Adar; Hsu, Ja-Wen; Spruijt-Metz, Donna] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
   [Weigensberg, Marc J.] Univ So Calif, Keck Sch Med, Dept Pediat, Los Angeles, CA 90033 USA.
C3 University of Southern California; University of Southern California;
   University of Southern California
RP Donoho, CJ (corresponding author), Univ So Calif, Davis Sch Gerontol, Los Angeles, CA 90089 USA.
EM donoho@usc.edu
FU National Cancer Institute (NCI), NCI Centers for Transdisciplinary
   Research on Energetics and Cancer (TREC) [U54-CA-116848]; National
   Institute on Aging, Multidisciplinary Research Training in Gerontology
   (NIA) [5-T32-AG000037]
FX The National Cancer Institute (NCI), NCI Centers for Transdisciplinary
   Research on Energetics and Cancer (TREC, U54-CA-116848), and the
   National Institute on Aging, Multidisciplinary Research Training in
   Gerontology (NIA, 5-T32-AG000037) provided support for this work. The
   funding sources had no further role in study design; in the collection,
   analysis and interpretation of data; in the writing of the report; and
   in the decision to submit the paper for publication. We thank Ana
   Romero, Adriana Padilla, Britni Belcher, Arianna McClain, and Selena
   Nguyen-Rodriguez for their roles in development, data collection and
   management of this project. We also thank all of the participants and
   their families for their time and dedication to this study.
CR Adam TC, 2007, PHYSIOL BEHAV, V91, P449, DOI 10.1016/j.physbeh.2007.04.011
   [Anonymous], 2000, Diabetes Care, V23, pS20
   Ball GDC, 2006, INT J PEDIATR OBES, V1, P210, DOI 10.1080/17477160600913578
   Bartels M, 2003, BEHAV GENET, V33, P421, DOI 10.1023/A:1025321609994
   Booker CL, 2004, ETHNIC HEALTH, V9, P369, DOI 10.1080/1355785042000285384
   Brambilla P, 2006, INT J OBESITY, V30, P23, DOI 10.1038/sj.ijo.0803163
   Brunner EJ, 2007, AM J EPIDEMIOL, V165, P828, DOI 10.1093/aje/kwk058
   Chida Y, 2009, BIOL PSYCHOL, V80, P265, DOI 10.1016/j.biopsycho.2008.10.004
   Clow A, 2004, STRESS, V7, P29, DOI 10.1080/10253890410001667205
   Cohen J., 2003, APPL MULTIPLE REGRES, P703, DOI DOI 10.2307/2064799
   Cohen S., 1995, Measuring Stress: A Guide for Health and Social Scientists, DOI DOI 10.1093/OSO/9780195086416.003.0001
   Dallman MF, 2005, BRAIN BEHAV IMMUN, V19, P275, DOI 10.1016/j.bbi.2004.11.004
   Epel E, 2004, ANN NY ACAD SCI, V1032, P208, DOI 10.1196/annals.1314.022
   Fields DA, 2002, AM J CLIN NUTR, V75, P453, DOI 10.1093/ajcn/75.3.453
   Goran MI, 2003, J CLIN ENDOCR METAB, V88, P1417, DOI 10.1210/jc.2002-021442
   Johnson WD, 2009, ARCH PEDIAT ADOL MED, V163, P371, DOI 10.1001/archpediatrics.2009.3
   Kahn HS, 2005, J PEDIATR-US, V146, P482, DOI 10.1016/j.jpeds.2004.12.028
   Kudielka BM, 2010, STRESS, V13, P1, DOI 10.3109/10253890902874913
   Kunz-Ebrecht SR, 2004, PSYCHONEUROENDOCRINO, V29, P516, DOI 10.1016/S0306-4530(03)00072-6
   Kuo LE, 2008, ANN NY ACAD SCI, V1148, P232, DOI 10.1196/annals.1410.035
   Kyrou I, 2006, ANN NY ACAD SCI, V1083, P77, DOI 10.1196/annals.1367.008
   Manolopoulos KN, 2010, INT J OBESITY, V34, P949, DOI 10.1038/ijo.2009.286
   Maxwell SE, 2004, PSYCHOL METHODS, V9, P147, DOI 10.1037/1082-989X.9.2.147
   Narayan KMV, 2003, JAMA-J AM MED ASSOC, V290, P1884, DOI 10.1001/jama.290.14.1884
   Narumi H, 2009, INT J CARDIOL, V135, P150, DOI 10.1016/j.ijcard.2008.03.044
   Ogden Cynthia L, 2010, Natl Health Stat Report, P1
   Porter SA, 2009, DIABETES CARE, V32, P1068, DOI 10.2337/dc08-2280
   Pou KM, 2007, CIRCULATION, V116, P1234, DOI 10.1161/CIRCULATIONAHA.107.710509
   Roberts C, 2007, OBESITY, V15, P3045, DOI 10.1038/oby.2007.363
   Rohleder N, 2007, PERS SOC PSYCHOL B, V33, P69, DOI 10.1177/0146167206293986
   Rudolph KD, 2002, J ADOLESCENT HEALTH, V30, P3, DOI 10.1016/S1054-139X(01)00383-4
   Schlotz W, 2004, PSYCHOSOM MED, V66, P207, DOI 10.1097/01.psy.0000116715.78238.56
   SEIDELL JC, 1990, AM J CLIN NUTR, V51, P953, DOI 10.1093/ajcn/51.6.953
   Shively CA, 2009, OBESITY, V17, P1513, DOI 10.1038/oby.2009.74
   Steptoe A, 2004, INT J OBESITY, V28, P1168, DOI 10.1038/sj.ijo.0802715
   Therrien F, 2007, OBESITY, V15, P377, DOI 10.1038/oby.2007.509
   Thomas EL, 2003, INT J OBESITY, V27, P211, DOI 10.1038/sj.ijo.802229
   van Jaarsveld CHM, 2009, OBESITY, V17, P2155, DOI 10.1038/oby.2009.183
   Wüst S, 2009, PSYCHONEUROENDOCRINO, V34, P972, DOI 10.1016/j.psyneuen.2009.01.011
   Wüst S, 2004, ANN NY ACAD SCI, V1032, P52, DOI 10.1196/annals.1314.005
   Wust Stefan, 2000, Noise Health, V2, P79
   Zhang C, 2008, CIRCULATION, V117, P1658, DOI 10.1161/CIRCULATIONAHA.107.739714
NR 42
TC 30
Z9 35
U1 0
U2 6
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1930-7381
J9 OBESITY
JI Obesity
PD MAY
PY 2011
VL 19
IS 5
BP 946
EP 952
DI 10.1038/oby.2010.287
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 755LS
UT WOS:000289933300011
PM 21127479
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Van Buiten, CB
   Wu, GJ
   Lam, YY
   Zhao, LP
   Raskin, I
AF Van Buiten, Charlene B.
   Wu, Guojun
   Lam, Yan Y.
   Zhao, Liping
   Raskin, Ilya
TI Elemental iron modifies the redox environment of the gastrointestinal
   tract: A novel therapeutic target and test for metabolic syndrome
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Iron; Metabolic syndrome; Reactive oxygen species; Leaky gut; Microbiome
ID GUT MICROBIOTA; AKKERMANSIA-MUCINIPHILA; INTESTINAL INFLAMMATION;
   INSULIN-RESISTANCE; OXYGEN; DIET; OBESITY; INGESTION; ABUNDANCE; STRESS
AB Metabolic syndrome (MetS, i.e., type 2 diabetes and obesity) is often associated with dysbiosis, inflammation, and leaky gut syndrome, which increase the content of oxygen and reactive oxygen species (ROS) in the gastrointestinal (GI) tract. Using near-infrared fluorescent, in situ imaging of ROS, we evaluated the effects of oral administration of elemental iron powder (Fe0) on luminal ROS in the GI tract and related these changes to glucose metabolism and the gut microbiome. C57Bl/6J mice fed low-fat or high-fat diets and gavaged with Fe0 (2.5 g per kg), in both single- and repeat-doses, demonstrated decreased levels of luminal ROS. Fourteen days of repeated Fe0 administration reduced hyperglycemia and improved glucose tolerance in the obese and hyperglycemic animals compared to the untreated obese controls and reduced the relative amount of iron oxides in the feces, which indicated an increased redox environment of the GI tract. We determined that Fe0 administration can also be used as a diagnostic assay to assess the GI microenvironment. Improved metabolic outcomes and decreased gastrointestinal ROS in Fe0-treated, high-fat diet-fed animals correlated with the increase in a coabundance group of beneficial bacteria, including Lactobacillus, and the suppression of detrimental populations, including Oscillibacter, Peptococcus, and Intestinimonas. Daily Fe0 treatment also increased the relative abundance of amplicon sequence variants that lacked functional enzymatic antioxidant systems, which is consistent with the ability of Fe0 to scavenge ROS and oxygen in the GI, thus favoring the growth of oxygensensitive bacteria. These findings delineate a functional role for antioxidants in modification of the GI microenvironment and subsequent reversal of metabolic dysfunction.
C1 [Van Buiten, Charlene B.] Colorado State Univ, Coll Hlth & Human Sci, Dept Food Sci & Human Nutr, Ft Collins, CO 80525 USA.
   [Van Buiten, Charlene B.; Raskin, Ilya] Rutgers State Univ, Sch Environm & Biol Sci, Dept Plant Biol, New Brunswick, NJ 08901 USA.
   [Wu, Guojun; Lam, Yan Y.; Zhao, Liping] Rutgers State Univ, Sch Environm & Biol Sci, Dept Biochem & Microbiol, New Brunswick, NJ 08901 USA.
   [Wu, Guojun; Lam, Yan Y.; Zhao, Liping] Rutgers State Univ, Ctr Microbiome, New Jersey Inst Food Nutr & Hlth, New Brunswick, NJ 80901 USA.
C3 Colorado State University System; Colorado State University Fort
   Collins; Rutgers University System; Rutgers University New Brunswick;
   Rutgers University System; Rutgers University New Brunswick; Rutgers
   University System; Rutgers University New Brunswick
RP Van Buiten, CB (corresponding author), Colorado State Univ, Coll Hlth & Human Sci, Dept Food Sci & Human Nutr, Ft Collins, CO 80525 USA.
EM charlene.vanbuiten@colostate.edu
RI Zhao, Liping/AEA-4833-2022; Van Buiten, Charlene/AFT-5465-2022; Wu,
   Guuojun/AHB-4249-2022
OI Van Buiten, Charlene B./0000-0001-9613-9100; Raskin,
   Ilya/0000-0002-3025-8112; Wu, Guojun/0000-0002-7910-2813
FU National Center for Complementary and Integrative Health, National
   Institute of Health (NIH-NCCIH) [1R01AT008618-01]; NIH-NCCIH
   [5T32AT004094]
FX This work was partially funded by the National Center for Complementary
   and Integrative Health, National Institute of Health (NIH-NCCIH) grant
   (1R01AT008618-01) and CBV was funded by an NIH-NCCIH Training Grant
   (5T32AT004094).
CR Abe K., 1983, WARMING DEVICE GENER
   Albenberg L, 2014, GASTROENTEROLOGY, V147, P1055, DOI 10.1053/j.gastro.2014.07.020
   Allen-Blevins CR, 2017, PEERJ, V5, DOI 10.7717/peerj.2876
   Anhê FF, 2015, GUT, V64, P872, DOI 10.1136/gutjnl-2014-307142
   Apprill A, 2015, AQUAT MICROB ECOL, V75, P129, DOI 10.3354/ame01753
   Aschbacher K, 2013, PSYCHONEUROENDOCRINO, V38, P1698, DOI 10.1016/j.psyneuen.2013.02.004
   Aviello G, 2017, BRIT J PHARMACOL, V174, P1704, DOI 10.1111/bph.13428
   BLAND JM, 1995, BRIT MED J, V310, P446, DOI 10.1136/bmj.310.6977.446
   Blandino G, 2016, DIABETES METAB, V42, P303, DOI 10.1016/j.diabet.2016.04.004
   Bokulich NA, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0470-z
   Bolyen E, 2019, NAT BIOTECHNOL, V37, P852, DOI 10.1038/s41587-019-0209-9
   Breiman L., 2001, Machine Learning, V45, P5, DOI 10.1023/A:1010933404324
   BRUNE A, 1995, APPL ENVIRON MICROB, V61, P2681, DOI 10.1128/AEM.61.7.2681-2687.1995
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Cani PD, 2016, MOL NUTR FOOD RES, V60, P58, DOI 10.1002/mnfr.201500406
   Chiva-Blanch G, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/5812401
   Chlosta S, 2006, INFECT IMMUN, V74, P3065, DOI 10.1128/IAI.74.5.3065-3067.2006
   Choy YY, 2013, J AGR FOOD CHEM, V61, P121, DOI 10.1021/jf301939e
   Cichello SA, 2015, J FOOD SCI TECH MYS, V52, P1889, DOI 10.1007/s13197-014-1265-2
   CROMPTON DW, 1965, J EXP BIOL, V43, P473
   Alves JLD, 2016, FRONT PHYSIOL, V7, DOI 10.3389/fphys.2016.00448
   de Kort S, 2011, OBES REV, V12, P449, DOI 10.1111/j.1467-789X.2010.00845.x
   Douglas GM, 2019, BIORXIV, DOI [10.1101/672295, DOI 10.1101/672295]
   Due V. Lind, 2003, ACTA ANAESTH SCAND, V47, P371
   Fan N, 2017, EXP EYE RES, V161, P71, DOI 10.1016/j.exer.2017.06.004
   Fändriks L, 2017, J INTERN MED, V281, P319, DOI 10.1111/joim.12584
   Faust K, 2012, NAT REV MICROBIOL, V10, P538, DOI 10.1038/nrmicro2832
   Felgines C, 2010, BRIT J NUTR, V103, P1738, DOI 10.1017/S0007114510000061
   GODA F, 1995, MAGN RESON MED, V33, P237, DOI 10.1002/mrm.1910330214
   Gong SQ, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00297
   Graziani G, 2005, GUT, V54, P193, DOI 10.1136/gut.2004.046292
   Jaeggi T, 2015, GUT, V64, P731, DOI 10.1136/gutjnl-2014-307720
   Kolde R., PRETTY HEATMAPS
   Kovatcheva-Datchary P, 2015, CELL METAB, V22, P971, DOI 10.1016/j.cmet.2015.10.001
   Kuhn P, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0198716
   Kundu K, 2009, ANGEW CHEM INT EDIT, V48, P299, DOI 10.1002/anie.200804851
   Lam YY, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034233
   Larsen FJ, 2006, NEW ENGL J MED, V355, P2792, DOI 10.1056/NEJMc062800
   Lim SM, 2016, NUTR RES, V36, P337, DOI 10.1016/j.nutres.2015.12.001
   LOVLEY DR, 1986, APPL ENVIRON MICROB, V51, P683, DOI 10.1128/AEM.51.4.683-689.1986
   Martin M., 2011, EMBnet J, V17, P10, DOI DOI 10.14806/EJ.17.1.200
   Matsuzawa-Nagata N, 2008, METABOLISM, V57, P1071, DOI 10.1016/j.metabol.2008.03.010
   Million M., 2018, Hum. Micro J., V10, P27, DOI DOI 10.1016/J.HUMIC.2018.07.002
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Pagani A, 2011, BLOOD, V118, P736, DOI 10.1182/blood-2011-02-337212
   Parada AE, 2016, ENVIRON MICROBIOL, V18, P1403, DOI 10.1111/1462-2920.13023
   Paradis E, 2004, BIOINFORMATICS, V20, P289, DOI [10.1093/bioinformatics/bty633, 10.1093/bioinformatics/btg412]
   Petersson J, 2007, AM J PHYSIOL-GASTR L, V292, pG718, DOI 10.1152/ajpgi.00435.2006
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Prunty MC, 2015, INVEST OPHTH VIS SCI, V56, P5862, DOI 10.1167/iovs.15-16810
   Quast Christian, 2013, Nucleic Acids Res, V41, pD590, DOI 10.1093/nar/gks1219
   Rocha BS, 2020, FREE RADICAL BIO MED, V149, P37, DOI 10.1016/j.freeradbiomed.2020.02.001
   Roopchand DE, 2015, DIABETES, V64, P2847, DOI 10.2337/db14-1916
   Sadlowski CM, 2017, MOL SYST DES ENG, V2, P191, DOI 10.1039/c7me00014f
   Selvam S, 2011, BIOMATERIALS, V32, P7785, DOI 10.1016/j.biomaterials.2011.07.020
   SHANAS MN, 1969, CLIN TOXICOL, V2, P37, DOI 10.3109/15563656908990912
   Sharma S, 2019, J NUTR BIOCHEM, V63, P101, DOI 10.1016/j.jnutbio.2018.10.003
   Slesak I, 2016, ASTROBIOLOGY, V16, P348, DOI 10.1089/ast.2015.1328
   SORENSEN J, 1982, APPL ENVIRON MICROB, V43, P319
   STOOKEY LL, 1970, ANAL CHEM, V42, P779, DOI 10.1021/ac60289a016
   Swain JH, 2003, J NUTR, V133, P3546, DOI 10.1093/jn/133.11.3546
   Tam AYB, 2008, CLIN TOXICOL, V46, P900, DOI 10.1080/15563650701711086
   Teixeira TFS, 2012, NUTR RES, V32, P637, DOI 10.1016/j.nutres.2012.07.003
   Teixeira TFS, 2012, CLIN NUTR, V31, P735, DOI 10.1016/j.clnu.2012.02.009
   Wang J., 2018, PeerJ Preprints, P2167, DOI DOI 10.7287/PEERJ.PREPRINTS.26872V1
   Wang JJ, 2015, ISME J, V9, P1, DOI 10.1038/ismej.2014.99
   Weiland JL, 2017, WILD ENVIRON MED, V28, P246, DOI 10.1016/j.wem.2017.04.006
   Wickham H., 2016, GGPLOT2, P189, DOI [DOI 10.1007/978-3-319-24277-49, 10.1007/978-3-319-24277-49]
   Wu HH, 2014, J FOOD DRUG ANAL, V22, P86, DOI 10.1016/j.jfda.2014.01.007
   Xie LQ, 2012, ARTHRITIS RHEUM-US, V64, P1899, DOI 10.1002/art.34370
   Zhang CH, 2015, EBIOMEDICINE, V2, P968, DOI 10.1016/j.ebiom.2015.07.007
   Zhang L, 2018, J NUTR BIOCHEM, V56, P142, DOI 10.1016/j.jnutbio.2018.02.009
   Zhang XQ, 2018, FOOD FUNCT, V9, P806, DOI [10.1039/c7fo00893g, 10.1039/C7FO00893G]
   Zimmermann MB, 2010, AM J CLIN NUTR, V92, P1406, DOI 10.3945/ajcn.110.004564
NR 74
TC 5
Z9 7
U1 3
U2 20
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD MAY 20
PY 2021
VL 168
BP 203
EP 213
DI 10.1016/j.freeradbiomed.2021.03.032
EA APR 2021
PG 11
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA RQ4AK
UT WOS:000642362400001
PM 33831549
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Zec, MM
   Krga, I
   Takic, M
   Debeljak-Martacic, J
   Koricanac, G
   Rankovic, S
   Popovic, T
   Pantelic, M
   Glibetic, M
AF Zec, Manja M.
   Krga, Irena
   Takic, Marija
   Debeljak-Martacic, Jasmina
   Koricanac, Goran
   Rankovic, Slavica
   Popovic, Tamara
   Pantelic, Marija
   Glibetic, Maria
TI Walnut Consumption Induces Tissue-Specific Omega-6/Omega-3 Decrease in
   High-Fructose-Fed Wistar Rats
SO ACS OMEGA
LA English
DT Article
ID FATTY-ACID-COMPOSITION; DE-NOVO LIPOGENESIS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; ADIPOSE-TISSUE; BLOOD-PRESSURE;
   MIXED NUTS; SERUM; LIVER
AB Increased dietary, blood, and tissue n-6/n-3 fatty acid ratios are associated with obesity and metabolic syndrome. Due to Westernized dietary patterns, the increasing n-6/n-3 ratio is of growing concern worldwide, and dietary strategies aimed at its lowering are of public health importance. Walnuts are rich in dietary fats, and their consumption promotes cardiometabolic health. This study aimed to examine the effect of 6-week walnut consumption on tissue-specific n-6/n-3 ratio and fatty acid metabolic conversion in fructose-fed rats with a cluster of metabolic disorders. Male Wistar rats were fed a standard diet with or without 10% fructose in drinking water for 9 weeks. Diets of half of the animals were then supplemented with walnuts (2.4 g/day) for 6 weeks, upon which fatty acid profiles were determined in plasma, liver, adipose tissue, and kidney total lipids. Results showed that walnuts induced significant decreases in the n-6/n-3 content of total lipid pool in plasma and examined tissues, irrespective of metabolic burden. Walnut intervention decreased plasma and liver palmitoleic/palmitic, arachidonic/linoleic, and docosahexaenoic/alpha-linolenic acid ratios. It also modulated individual fatty acid levels by reducing arachidonic and palmitic acid and increasing alpha-linolenic, eicosapentaenoic, and docosapentaenoic acid in plasma and most tissues. Our study demonstrated that 6-week consumption of walnuts favorably modulated n-6/n-3 plasma and tissue ratio in male Wistar rats regardless of high-fructose feeding, underscoring the promising potential of walnuts in both prevention and treatment of the metabolic syndrome.
C1 [Zec, Manja M.; Krga, Irena; Takic, Marija; Debeljak-Martacic, Jasmina; Rankovic, Slavica; Popovic, Tamara; Glibetic, Maria] Univ Belgrade, Ctr Excellence Nutr & Metab Res, Inst Med Res, Natl Inst Republ Serbia, Belgrade 11000, Serbia.
   [Koricanac, Goran; Pantelic, Marija] Univ Belgrade, Vinca Inst Nucl Sci, Natl Inst Republ Serbia, Lab Mol Biol & Endocrinol, Belgrade 11001, Serbia.
C3 University of Belgrade; University of Belgrade
RP Zec, MM (corresponding author), Univ Belgrade, Ctr Excellence Nutr & Metab Res, Inst Med Res, Natl Inst Republ Serbia, Belgrade 11000, Serbia.
EM manjazecimr@gmail.com
RI Korićanac, Goran/ABF-6544-2021; Pantelic, Marija/NBX-1547-2025; Krga,
   Irena/AAC-4879-2020; Zec, Manja/T-5942-2019
OI Koricanac, Goran/0000-0002-9852-3330; Pantelic,
   Marija/0000-0001-8457-0585; Debeljak Martacic,
   Jasmina/0000-0002-9605-3793; Zec, Manja/0000-0001-5283-9295; Krga,
   Irena/0000-0002-2073-2896
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [451-03-68/2020-14/200015, 451-03-68/2020-14/200017]
FX This work was supported by the Ministry of Education, Science and
   Technological Development of the Republic of Serbia, under the contract
   numbers 451-03-68/2020-14/200015 and 451-03-68/2020-14/200017.
CR Almario RU, 2001, AM J CLIN NUTR, V74, P72
   [Anonymous], 2018, REFERENCE MODULE FOO
   Bashan I, 2018, J FOOD QUALITY, DOI 10.1155/2018/4731826
   Bati B, 2015, CELL BIOCHEM BIOPHYS, V71, P1191, DOI 10.1007/s12013-014-0328-3
   Beulen Y, 2018, NUTRIENTS, V10, DOI 10.3390/nu10122011
   Boyer-Diaz Z, 2020, NUTRIENTS, V12, DOI 10.3390/nu12092627
   Boyer-Diaz Z, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102358
   Brenna JT, 2009, PROSTAG LEUKOTR ESS, V80, P85, DOI 10.1016/j.plefa.2009.01.004
   Cardinali DP, 2013, INT J MOL SCI, V14, P2502, DOI 10.3390/ijms14022502
   Casas-Agustench P, 2011, NUTR METAB CARDIOVAS, V21, P126, DOI 10.1016/j.numecd.2009.08.005
   Chilton FH, 2014, NUTRIENTS, V6, P1993, DOI 10.3390/nu6051993
   Choi Y, 2016, J NUTR BIOCHEM, V38, P70, DOI 10.1016/j.jnutbio.2016.08.013
   Choi Y, 2016, J NUTR BIOCHEM, V30, P116, DOI 10.1016/j.jnutbio.2015.12.005
   Chong MFF, 2008, AM J CLIN NUTR, V87, P817, DOI 10.1093/ajcn/87.4.817
   De Oliveira JC, 2013, MINERVA ENDOCRINOL, V38, P379
   Fink A, 2014, EUR J NUTR, V53, P645, DOI 10.1007/s00394-013-0573-z
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   Gencoglu H, 2020, J FOOD BIOCHEM, V44, DOI 10.1111/jfbc.13235
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Guasch-Ferré M, 2018, AM J CLIN NUTR, V108, P174, DOI 10.1093/ajcn/nqy091
   Guasch-Ferré M, 2017, J AM COLL CARDIOL, V70, P2519, DOI 10.1016/j.jacc.2017.09.035
   Halvorsen BL, 2006, AM J CLIN NUTR, V84, P95, DOI 10.1093/ajcn/84.1.95
   Hammad K. S. M., 2015, J FOOD NUTR RES, V3, P653
   Hellerstein MK, 1999, EUR J CLIN NUTR, V53, pS53, DOI 10.1038/sj.ejcn.1600744
   Hong MY, 2018, MOLECULES, V23, DOI 10.3390/molecules23123126
   Jackson KH, 2018, CURR ATHEROSCLER REP, V20, DOI 10.1007/s11883-018-0722-1
   Julibert A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071493
   Kassem AA, 2012, SCI WORLD J, DOI 10.1100/2012/851437
   Koletzko B, 2019, ANNU REV NUTR, V39, P21, DOI 10.1146/annurev-nutr-082018-124250
   Lee SM, 2019, RENAL FAILURE, V41, P211, DOI 10.1080/0886022X.2019.1591996
   Li AC, 2004, J LIPID RES, V45, P2161, DOI 10.1194/jlr.R400010-JLR200
   Luo T, 2016, J NUTR, V146, P1641, DOI 10.3945/jn.116.234419
   Mayneris-Perxachs J, 2014, CLIN NUTR, V33, P90, DOI 10.1016/j.clnu.2013.03.001
   Milutinovic DV, 2020, MOL NUTR FOOD RES, V64, DOI 10.1002/mnfr.201901141
   Njike VY, 2015, BMJ OPEN DIAB RES CA, V3, DOI 10.1136/bmjdrc-2015-000115
   Petrovic-Oggiano G, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010192
   Radcliffe JD, 2004, PLANT FOOD HUM NUTR, V59, P73, DOI 10.1007/s11130-004-0029-y
   Reagan-Shaw S, 2008, FASEB J, V22, P659, DOI 10.1096/fj.07-9574LSF
   Ros E, 2004, CIRCULATION, V109, P1609, DOI 10.1161/01.CIR.0000124477.91474.FF
   SABATE J, 1993, NEW ENGL J MED, V328, P603, DOI 10.1056/NEJM199303043280902
   Saha JK, 2005, EXP BIOL MED, V230, P777, DOI 10.1177/153537020523001012
   Scott NJA, 2017, NUTRIENTS, V9, DOI 10.3390/nu9070722
   Serhan CN, 2014, NATURE, V510, P92, DOI 10.1038/nature13479
   Simopoulos AP, 1999, LIPIDS, V34, pS297, DOI 10.1007/BF02562324
   Simopoulos AP, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030128
   Song LH, 2020, J MED FOOD, V23, P161, DOI 10.1089/jmf.2019.4468
   Sonnweber T, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19113285
   Stanisic J, 2021, INT J FOOD SCI NUTR, V72, P324, DOI 10.1080/09637486.2020.1796931
   Stanisic J, 2016, MOL CELL ENDOCRINOL, V420, P97, DOI 10.1016/j.mce.2015.11.032
   Sun Y, 2019, REJUV RES, V22, P306, DOI 10.1089/rej.2018.2140
   Tindall AM, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.118.011512
   Wu JHY, 2011, AM J CLIN NUTR, V94, P431, DOI 10.3945/ajcn.111.012054
   Xiao YJ, 2018, CLIN NUTR, V37, P831, DOI 10.1016/j.clnu.2017.04.011
   Yin W, 2012, J LIPID RES, V53, P51, DOI 10.1194/jlr.M019927
   Zambón D, 2000, ANN INTERN MED, V132, P538, DOI 10.7326/0003-4819-132-7-200004040-00039
   Zhang J., 2020, J AGR FOOD CHEM
NR 56
TC 11
Z9 12
U1 1
U2 4
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2470-1343
J9 ACS OMEGA
JI ACS Omega
PD NOV 3
PY 2020
VL 5
IS 43
BP 28136
EP 28145
DI 10.1021/acsomega.0c03784
PG 10
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA OR1NS
UT WOS:000589243500042
PM 33163796
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pahwa, R
   Singh, A
   Adams-Huet, B
   Devaraj, S
   Jialal, I
AF Pahwa, Roma
   Singh, Anand
   Adams-Huet, Beverley
   Devaraj, Sridevi
   Jialal, Ishwarlal
TI Increased inflammasome activity in subcutaneous adipose tissue of
   patients with metabolic syndrome
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article
DE adipose tissue; caspase 1; inflammasome; inflammation; interleukin
   1(IL-1); interleukin 18 (IL-18); metabolic syndrome
ID LIPOPOLYSACCHARIDE-BINDING PROTEIN; GROUP BOX PROTEIN-1; NLRP3
   INFLAMMASOME; INSULIN-RESISTANCE; NALP3 INFLAMMASOME; OXIDATIVE STRESS;
   URIC-ACID; ACTIVATION; OBESITY; TOLL
AB Aims The metabolic syndrome (MetS) is an inflammatory disorder associated with an increased risk for diabetes and atherosclerotic cardiovascular disease (ASCVD). Studies in patients and animal models of obesity and diabetes have shown increased NOD-like receptor family pyrin domain containing 3 (NLPR3) inflammasome activity. However, there is scanty data on the activity of the NLRP3 inflammasome in patients with nascent MetS. The aim of this study was to determine the status of the inflammasome in subcutaneous adipose tissue (SAT) of patients with nascent MetS without concomitant diabetes, ASCVD and smoking. Materials and Methods Patients with nascent MetS and controls were recruited from Sacramento County. Fasting blood samples were collected for biomediators of inflammation and SAT was obtained by biopsy for immunohistochemical (IHC) staining for caspase 1, IL-1 beta and IL-18. Results Caspase1, a marker of inflammasome activity and its downstream mediators IL-1 beta and IL-18 were significantly increased in SAT of patients with MetS compared to controls. Significant positive correlations of caspase 1 were obtained with certain cardio-metabolic features, biomediators of inflammation and markers of angiogenesis and fibrosis in SAT. Both mast cell and eosinophil abundance but not macrophage density correlated with caspase1. Conclusions We make the novel observation that the SAT of patients with nascent MetS displays increased NLRP3 inflammasome activity manifest by increased caspase 1 in SAT and this may contribute to increased insulin resistance, inflammation and SAT fibrosis in these patients.
C1 [Pahwa, Roma; Singh, Anand] NCI, NIH, Bethesda, MD 20892 USA.
   [Adams-Huet, Beverley] UT Southwestern Med Ctr, Ctr Biostat & Clin Sci, Dallas, TX USA.
   [Devaraj, Sridevi] Texas Childrens Hosp, Houston, TX 77030 USA.
   [Devaraj, Sridevi] Baylor Coll Med, Houston, TX 77030 USA.
   [Jialal, Ishwarlal] VA Med Ctr, 10535 Hosp Way, Mather, CA 95655 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Cancer Institute
   (NCI); University of Texas System; University of Texas Southwestern
   Medical Center Dallas; Baylor College of Medicine; Baylor College
   Medical Hospital; Baylor College of Medicine
RP Jialal, I (corresponding author), VA Med Ctr, 10535 Hosp Way, Mather, CA 95655 USA.
EM kjialal@gmail.com
RI Singh, Anand/KXR-8053-2024
OI Singh, Anand/0000-0003-4360-929X; Pahwa, Roma/0009-0006-0745-3581
CR Adams-Huet B, 2014, METAB SYNDR RELAT D, V12, P503, DOI 10.1089/met.2014.0092
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Bakker PJ, 2014, KIDNEY INT, V85, P1112, DOI 10.1038/ki.2013.503
   Bremer AA, 2011, J CLIN ENDOCR METAB, V96, pE1782, DOI 10.1210/jc.2011-1577
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Davis BK, 2011, ANNU REV IMMUNOL, V29, P707, DOI 10.1146/annurev-immunol-031210-101405
   Devaraj S, 2007, DIABETES, V56, P2790, DOI 10.2337/db07-0784
   Doyle SL, 2012, NAT MED, V18, P791, DOI 10.1038/nm.2717
   Duewell P, 2010, NATURE, V464, P1357, DOI 10.1038/nature08938
   Esser N, 2013, DIABETOLOGIA, V56, P2487, DOI 10.1007/s00125-013-3023-9
   Gasse P, 2009, AM J RESP CRIT CARE, V179, P903, DOI 10.1164/rccm.200808-1274OC
   Ghanim H, 2004, CIRCULATION, V110, P1564, DOI 10.1161/01.CIR.0000142055.53122.FA
   Goossens GH, 2012, MOL IMMUNOL, V50, P142, DOI 10.1016/j.molimm.2012.01.005
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Gurung P, 2012, J BIOL CHEM, V287, P34474, DOI 10.1074/jbc.M112.401406
   Gurung P, 2019, AM J PHYSIOL-ENDOC M, V316, pE504, DOI 10.1152/ajpendo.00462.2018
   Halle A, 2008, NAT IMMUNOL, V9, P857, DOI 10.1038/ni.1636
   Jialal I, 2017, DIABETES METAB, V43, P364, DOI 10.1016/j.diabet.2016.12.004
   Jialal I, 2014, ATHEROSCLEROSIS, V236, P182, DOI 10.1016/j.atherosclerosis.2014.06.022
   Jialal I, 2018, HORM MOL BIOL CLIN I, V33, DOI 10.1515/hmbci-2017-0074
   Jialal I, 2016, J DIABETES COMPLICAT, V30, P1434, DOI 10.1016/j.jdiacomp.2016.07.031
   Jialal I, 2015, ATHEROSCLEROSIS, V241, P130, DOI 10.1016/j.atherosclerosis.2015.04.814
   Jialal I, 2014, EXPERT REV ENDOCRINO, V9, P213, DOI 10.1586/17446651.2014.890046
   Jialal I, 2012, J CLIN ENDOCR METAB, V97, pE1844, DOI 10.1210/jc.2012-2498
   Jialal I, 2012, DIABETES CARE, V35, P900, DOI 10.2337/dc11-2375
   Kursawe R, 2016, DIABETES, V65, P610, DOI 10.2337/db15-1478
   L'homme L, 2013, J LIPID RES, V54, P2998, DOI 10.1194/jlr.M037861
   Lamkanfi M, 2014, CELL, V157, P1013, DOI 10.1016/j.cell.2014.04.007
   Lee HM, 2013, DIABETES, V62, P194, DOI 10.2337/db12-0420
   Martinon F, 2006, NATURE, V440, P237, DOI 10.1038/nature04516
   Martinon F, 2002, MOL CELL, V10, P417, DOI 10.1016/S1097-2765(02)00599-3
   Masters SL, 2010, NAT IMMUNOL, V11, P897, DOI 10.1038/ni.1935
   Mi Q, 2019, DIABETES-METAB RES, V35, DOI 10.1002/dmrr.3085
   Moussa K, 2019, J DIABETES COMPLICAT, V33, P535, DOI 10.1016/j.jdiacomp.2019.05.010
   Murphy AJ, 2016, CELL METAB, V23, P155, DOI 10.1016/j.cmet.2015.09.024
   Pahwa R, 2016, INT J OBESITY, V40, P907, DOI 10.1038/ijo.2016.32
   Reddy P, 2019, CLIN CHIM ACTA, V496, P35, DOI 10.1016/j.cca.2019.06.019
   Rheinheimer J, 2017, METABOLISM, V74, P1, DOI 10.1016/j.metabol.2017.06.002
   Sakimoto T, 2018, CORNEA, V37, pS86, DOI 10.1097/ICO.0000000000001717
   Schroder K, 2010, SCIENCE, V327, P296, DOI 10.1126/science.1184003
   Shao BZ, 2015, FRONT PHARMACOL, V6, DOI 10.3389/fphar.2015.00262
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Stienstra R, 2011, P NATL ACAD SCI USA, V108, P15324, DOI 10.1073/pnas.1100255108
   Stienstra R, 2010, CELL METAB, V12, P593, DOI 10.1016/j.cmet.2010.11.011
   Sun SY, 2012, DIABETES, V61, P1471, DOI 10.2337/db11-1389
   Unamuno X, 2021, CELL MOL IMMUNOL, V18, P1045, DOI 10.1038/s41423-019-0296-z
   Vandanmagsar B, 2011, NAT MED, V17, P179, DOI 10.1038/nm.2279
   Watanabe A, 2009, AM J PHYSIOL-GASTR L, V296, pG1248, DOI 10.1152/ajpgi.90223.2008
   Wen HT, 2011, NAT IMMUNOL, V12, P408, DOI 10.1038/ni.2022
   Wree A, 2014, HEPATOLOGY, V59, P898, DOI 10.1002/hep.26592
   Yin Z, 2014, MOL CELL ENDOCRINOL, V394, P80, DOI 10.1016/j.mce.2014.06.018
   Zhang SY, 2018, EBIOMEDICINE, V31, P202, DOI 10.1016/j.ebiom.2018.04.022
   Zhou RB, 2010, NAT IMMUNOL, V11, P136, DOI 10.1038/ni.1831
NR 53
TC 19
Z9 21
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD MAR
PY 2021
VL 37
IS 3
AR e3383
DI 10.1002/dmrr.3383
EA AUG 2020
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA QX9GJ
UT WOS:000556096200001
PM 32652811
DA 2025-06-11
ER

PT J
AU Kosgei, VJ
   Coelho, D
   Guéant-Rodriguez, RM
   Guéant, JL
AF Kosgei, Viola J.
   Coelho, David
   Gueant-Rodriguez, Rosa-Maria
   Gueant, Jean-Louis
TI Sirt1-PPARS Cross-Talk in Complex Metabolic Diseases and Inherited
   Disorders of the One Carbon Metabolism
SO CELLS
LA English
DT Review
DE Sirtuin1; peroxisome proliferator-activated receptor-gamma coactivator-1
   alpha; peroxisome proliferator activated receptors; obesity; metabolic
   syndrome; vitamin B12; folate; fetal programming; inherited metabolic
   disorders
ID PANCREATIC BETA-CELLS; FATTY-ACID OXIDATION; NF-KAPPA-B; INSULIN
   SENSITIVITY; SKELETAL-MUSCLE; ADIPOSE-TISSUE; HEPATIC STEATOSIS;
   RESVERATROL SUPPLEMENTATION; INFLAMMATORY PROCESSES; MATERNAL NUTRITION
AB Sirtuin1 (Sirt1) has a NAD (+) binding domain and modulates the acetylation status of peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC1 alpha) and Fork Head Box O1 transcription factor (Foxo1) according to the nutritional status. Sirt1 is decreased in obese patients and increased in weight loss. Its decreased expression explains part of the pathomechanisms of the metabolic syndrome, diabetes mellitus type 2 (DT2), cardiovascular diseases and nonalcoholic liver disease. Sirt1 plays an important role in the differentiation of adipocytes and in insulin signaling regulated by Foxo1 and phosphatidylinositol 3 '-kinase (PI3K) signaling. Its overexpression attenuates inflammation and macrophage infiltration induced by a high fat diet. Its decreased expression plays a prominent role in the heart, liver and brain of rat as manifestations of fetal programming produced by deficit in vitamin B12 and folate during pregnancy and lactation through imbalanced methylation/acetylation of PGC1 alpha and altered expression and methylation of nuclear receptors. The decreased expression of Sirt1 produced by impaired cellular availability of vitamin B12 results from endoplasmic reticulum stress through subcellular mislocalization of ELAVL1/HuR protein that shuttles Sirt1 mRNA between the nucleus and cytoplasm. Preclinical and clinical studies of Sirt1 agonists have produced contrasted results in the treatment of the metabolic syndrome. A preclinical study has produced promising results in the treatment of inherited disorders of vitamin B12 metabolism.
C1 [Kosgei, Viola J.; Coelho, David; Gueant-Rodriguez, Rosa-Maria; Gueant, Jean-Louis] Univ Lorraine, UMR Inserm N GERE Nutr Genet & Exposit Risques En, F-54500 Vandoeuvre Les Nancy, France.
   [Gueant-Rodriguez, Rosa-Maria; Gueant, Jean-Louis] Univ Lorraine, Univ Hosp Ctr, Dept Digest Dis, F-54500 Vandoeuvre Les Nancy, France.
   [Gueant-Rodriguez, Rosa-Maria; Gueant, Jean-Louis] Univ Lorraine, Univ Hosp Ctr, Dept Nutr & Endocrinol, F-54500 Vandoeuvre Les Nancy, France.
   [Gueant-Rodriguez, Rosa-Maria; Gueant, Jean-Louis] Univ Lorraine, Univ Hosp Ctr, Dept Mol Med, F-54500 Vandoeuvre Les Nancy, France.
   [Gueant-Rodriguez, Rosa-Maria; Gueant, Jean-Louis] Univ Lorraine, Univ Hosp Ctr, Natl Ctr Inborn Errors Metab, F-54500 Vandoeuvre Les Nancy, France.
C3 Universite de Lorraine; Institut National de la Sante et de la Recherche
   Medicale (Inserm); CHU de Nancy; Universite de Lorraine; CHU de Nancy;
   Universite de Lorraine; CHU de Nancy; Universite de Lorraine; Universite
   de Lorraine; CHU de Nancy
RP Guéant, JL (corresponding author), Univ Lorraine, UMR Inserm N GERE Nutr Genet & Exposit Risques En, F-54500 Vandoeuvre Les Nancy, France.; Guéant, JL (corresponding author), Univ Lorraine, Univ Hosp Ctr, Dept Digest Dis, F-54500 Vandoeuvre Les Nancy, France.; Guéant, JL (corresponding author), Univ Lorraine, Univ Hosp Ctr, Dept Nutr & Endocrinol, F-54500 Vandoeuvre Les Nancy, France.; Guéant, JL (corresponding author), Univ Lorraine, Univ Hosp Ctr, Dept Mol Med, F-54500 Vandoeuvre Les Nancy, France.; Guéant, JL (corresponding author), Univ Lorraine, Univ Hosp Ctr, Natl Ctr Inborn Errors Metab, F-54500 Vandoeuvre Les Nancy, France.
EM viokos84@yahoo.com; david.coelho@univ-lorraine.fr;
   rosa-maria.gueant-rodriguez@univ-lorraine.fr;
   jean-louis.gueant@univ-lorraine.fr
RI Guéant-Rodriguez, Rosa-Maria/ABK-8588-2022; Gueant,
   Jean-Louis/N-7298-2016; Coelho, David/F-6680-2011
OI Gueant, Jean-Louis/0000-0002-5067-042X; Coelho,
   David/0000-0001-7010-5789
FU FHU ARRIMAGE; French PIA project "Lorraine Universite d'Excellence"
   [ANR-15-IDEX-04-LUE]
FX This research was funded by FHU ARRIMAGE and the French PIA project
   "Lorraine Universite d'Excellence", reference ANR-15-IDEX-04-LUE.
CR Abdelmohsen K, 2007, MOL CELL, V25, P543, DOI 10.1016/j.molcel.2007.01.011
   Alcendor RR, 2007, CIRC RES, V100, P1512, DOI 10.1161/01.RES.0000267723.65696.4a
   [Anonymous], 2013, J AM HEART ASSOC
   Banerjee J, 2016, METABOLISM, V65, P1679, DOI 10.1016/j.metabol.2016.06.011
   Battaglia-Hsu SF, 2018, NUCLEIC ACIDS RES, V46, P7844, DOI 10.1093/nar/gky634
   Berman AY, 2017, NPJ PRECIS ONCOL, V1, DOI 10.1038/s41698-017-0038-6
   Bhatt JK, 2012, NUTR RES, V32, P537, DOI 10.1016/j.nutres.2012.06.003
   Bison A, 2016, SCI REP-UK, V6, DOI 10.1038/srep37207
   Blaise SA, 2007, AM J PHYSIOL-ENDOC M, V293, pE1492, DOI 10.1152/ajpendo.00255.2007
   Bordone L, 2006, PLOS BIOL, V4, P210, DOI 10.1371/journal.pbio.0040031
   Brandon AE, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0121959
   Brasnyó P, 2011, BRIT J NUTR, V106, P383, DOI 10.1017/S0007114511000316
   Brunet A, 2004, SCIENCE, V303, P2011, DOI 10.1126/science.1094637
   Bujanda L, 2008, BMC GASTROENTEROL, V8, DOI 10.1186/1471-230X-8-40
   Cantó C, 2009, TRENDS ENDOCRIN MET, V20, P325, DOI 10.1016/j.tem.2009.03.008
   Cantó C, 2009, CURR OPIN LIPIDOL, V20, P98, DOI 10.1097/MOL.0b013e328328d0a4
   Caton PW, 2010, J ENDOCRINOL, V205, P97, DOI 10.1677/JOE-09-0345
   Chalkiadaki A, 2012, CELL METAB, V16, P180, DOI 10.1016/j.cmet.2012.07.003
   CHAWLA A, 1994, ENDOCRINOLOGY, V135, P798, DOI 10.1210/en.135.2.798
   Cheang WS, 2019, PHARMACOL RES, V139, P384, DOI 10.1016/j.phrs.2018.11.041
   Chen D, 2008, GENE DEV, V22, P1753, DOI 10.1101/gad.1650608
   Chen LF, 2002, EMBO J, V21, P6539, DOI 10.1093/emboj/cdf660
   Cho SJ, 2012, BRIT J NUTR, V108, P2166, DOI 10.1017/S0007114512000347
   Chooi YC, 2019, METABOLISM, V92, P6, DOI 10.1016/j.metabol.2018.09.005
   Cuyàs E, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00657
   Desai T, 2019, NUTR DIABETES, V9, DOI 10.1038/s41387-019-0075-z
   Dolinsky VW, 2013, BBA-MOL BASIS DIS, V1832, P1723, DOI 10.1016/j.bbadis.2013.05.018
   Dolinsky VW, 2011, BBA-MOL BASIS DIS, V1812, P1477, DOI 10.1016/j.bbadis.2011.06.010
   Donath MY, 2011, NAT REV IMMUNOL, V11, P98, DOI 10.1038/nri2925
   Durham SK, 1999, ENDOCRINOLOGY, V140, P3140, DOI 10.1210/en.140.7.3140
   Feige JN, 2008, CELL METAB, V8, P347, DOI 10.1016/j.cmet.2008.08.017
   Feigerlova E, 2016, FASEB J, V30, P3598, DOI 10.1096/fj.201600332R
   Feingold KR, 2008, J LIPID RES, V49, P2179, DOI 10.1194/jlr.M800233-JLR200
   Francioso A, 2014, MED CHEM, V10, P237, DOI 10.2174/15734064113096660053
   Franco JG, 2013, J NUTR BIOCHEM, V24, P960, DOI 10.1016/j.jnutbio.2012.06.019
   Frelut ML, 2011, INT J PEDIATR OBES, V6, pE312, DOI 10.3109/17477166.2010.486835
   Frye RA, 2000, BIOCHEM BIOPH RES CO, V273, P793, DOI 10.1006/bbrc.2000.3000
   Fuentes E, 2013, MOL MED REP, V8, P1611, DOI 10.3892/mmr.2013.1714
   Fuentes E, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/136584
   Fulco M, 2003, MOL CELL, V12, P51, DOI 10.1016/S1097-2765(03)00226-0
   Gambini J, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/837042
   Garcia MM, 2011, J PATHOL, V225, P324, DOI 10.1002/path.2881
   Ghemrawi R, 2013, CELL DEATH DIS, V4, DOI 10.1038/cddis.2013.69
   Ghemrawi R, 2019, METABOLISM, V101, DOI 10.1016/j.metabol.2019.153992
   Gillum MP, 2011, DIABETES, V60, P3235, DOI 10.2337/db11-0616
   Godfrey KM, 2000, AM J CLIN NUTR, V71, p1344S, DOI 10.1093/ajcn/71.5.1344s
   Green R, 2017, BLOOD, V129, P2603, DOI 10.1182/blood-2016-10-569186
   Guéant JL, 2014, PFLUG ARCH EUR J PHY, V466, P833, DOI 10.1007/s00424-013-1339-4
   Guéant JL, 2013, TRENDS ENDOCRIN MET, V24, P279, DOI 10.1016/j.tem.2013.01.010
   Guo XF, 2018, CRIT REV FOOD SCI, V58, P3016, DOI 10.1080/10408398.2017.1349076
   Hariri N, 2010, NUTR RES REV, V23, P270, DOI 10.1017/S0954422410000168
   Hayashi C, 2004, DIABETES RES CLIN PR, V66, P269, DOI 10.1016/j.diabres.2004.03.013
   Heming M, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.00893
   Herranz D, 2010, NAT COMMUN, V1, DOI 10.1038/ncomms1001
   Hoffmann E, 2013, BRIT J CLIN PHARMACO, V75, P186, DOI 10.1111/j.1365-2125.2012.04340.x
   Houtkooper RH, 2010, ENDOCR REV, V31, P194, DOI 10.1210/er.2009-0026
   Hui XY, 2017, EMBO REP, V18, P645, DOI 10.15252/embr.201643184
   Jimenez-Gomez Y, 2013, CELL METAB, V18, P533, DOI 10.1016/j.cmet.2013.09.004
   Johnson AR, 2012, IMMUNOL REV, V249, P218, DOI 10.1111/j.1600-065X.2012.01151.x
   Kaeberlein M, 1999, GENE DEV, V13, P2570, DOI 10.1101/gad.13.19.2570
   Kauppinen A, 2013, CELL SIGNAL, V25, P1939, DOI 10.1016/j.cellsig.2013.06.007
   Kim S, 2011, BIOCHEM PHARMACOL, V81, P1343, DOI 10.1016/j.bcp.2011.03.012
   Kurgvietiene L, 2016, MEDICINA-LITHUANIA, V52, P148, DOI 10.1016/j.medici.2016.03.003
   Kwon J, 2019, EXP MOL MED, V51, DOI 10.1038/s12276-019-0232-4
   Lamichane S, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19040949
   Landry J, 2000, P NATL ACAD SCI USA, V97, P5807, DOI 10.1073/pnas.110148297
   Lee JH, 2009, DIABETES, V58, P344, DOI 10.2337/db07-1795
   Lewis SJ, 2009, BRIT J NUTR, V102, P493, DOI 10.1017/S0007114509231746
   Li XL, 2013, ACTA BIOCH BIOPH SIN, V45, P51, DOI 10.1093/abbs/gms108
   Li Y, 2011, FASEB J, V25, P1664, DOI 10.1096/fj.10-173492
   Libri V, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051395
   Liu ZJ, 2016, J LIPID RES, V57, P1373, DOI 10.1194/jlr.M063537
   Liu ZG, 2015, PLOS ONE, V10, DOI [10.1371/journal.pone.0128274, 10.1371/journal.pone.0140839]
   Bargut TCL, 2017, HORM MOL BIOL CLIN I, V31, DOI 10.1515/hmbci-2016-0051
   Luu L, 2013, DIABETOLOGIA, V56, P2010, DOI 10.1007/s00125-013-2946-5
   Ma XR, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00473
   Mariani S, 2016, OBES SURG, V26, P1215, DOI 10.1007/s11695-015-1859-4
   Matsuda M, 2014, REV ENDOCR METAB DIS, V15, P1, DOI 10.1007/s11154-013-9271-7
   Mattison JA, 2014, CELL METAB, V20, P183, DOI 10.1016/j.cmet.2014.04.018
   Medina-Gomez G, 2007, PLOS GENET, V3, DOI 10.1371/journal.pgen.0030064
   Melhem H, 2016, GUT, V65, P595, DOI 10.1136/gutjnl-2014-307030
   Milne JC, 2007, NATURE, V450, P712, DOI 10.1038/nature06261
   Minor RK, 2011, SCI REP-UK, V1, DOI 10.1038/srep00070
   Movahed A, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010161
   Mozafari M, 2015, NAT PROD COMMUN, V10, P335
   Nakae J, 2006, J CLIN INVEST, V116, P2473, DOI 10.1172/JCI25518
   Nemoto S, 2005, J BIOL CHEM, V280, P16456, DOI 10.1074/jbc.M501485200
   Noh RM, 2017, OPEN HEART, V4, DOI 10.1136/openhrt-2017-000647
   Odegaard JI, 2008, CELL METAB, V7, P496, DOI 10.1016/j.cmet.2008.04.003
   Andrade JMO, 2014, NUTRITION, V30, P915, DOI 10.1016/j.nut.2013.11.016
   Pan QR, 2015, NUTR RES, V35, P576, DOI 10.1016/j.nutres.2015.05.006
   Perrini S, 2020, INT J OBESITY, V44, P307, DOI 10.1038/s41366-019-0436-7
   Pinho AV, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0128012
   Pooya S, 2012, J HEPATOL, V57, P344, DOI 10.1016/j.jhep.2012.03.028
   Pourié G, 2015, FASEB J, V29, P3713, DOI 10.1096/fj.14-264267
   Prud'homme GJ, 2014, BIOCHEM BIOPH RES CO, V452, P649, DOI 10.1016/j.bbrc.2014.08.135
   Purushotham A, 2009, CELL METAB, V9, P327, DOI 10.1016/j.cmet.2009.02.006
   Qiang L, 2007, MOL CELL BIOL, V27, P4698, DOI 10.1128/MCB.02279-06
   Qiang L, 2012, CELL, V150, P620, DOI 10.1016/j.cell.2012.06.027
   Qiao LP, 2006, J BIOL CHEM, V281, P39915, DOI 10.1074/jbc.M607215200
   Ramachandran D, 2011, FEBS J, V278, P1167, DOI 10.1111/j.1742-4658.2011.08042.x
   Rappou E, 2016, J CLIN ENDOCR METAB, V101, P1263, DOI 10.1210/jc.2015-3054
   Rodgers JT, 2005, NATURE, V434, P113, DOI 10.1038/nature03354
   Rogina B, 2004, P NATL ACAD SCI USA, V101, P15998, DOI 10.1073/pnas.0404184101
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Schenk S, 2011, J CLIN INVEST, V121, P4281, DOI 10.1172/JCI58554
   Scisciola L, 2020, EPIGENETICS-US, V15, P664, DOI 10.1080/15592294.2019.1704349
   Sigit FS, 2020, DIABETOL METAB SYNDR, V12, DOI 10.1186/s13098-019-0503-1
   Sin TK, 2015, CELL PHYSIOL BIOCHEM, V35, P541, DOI 10.1159/000369718
   Singh BK, 2013, J BIOL CHEM, V288, P30365, DOI 10.1074/jbc.M113.504845
   St-Pierre J, 2006, CELL, V127, P397, DOI 10.1016/j.cell.2006.09.024
   Stewart CP, 2011, J NUTR, V141, P1912, DOI 10.3945/jn.111.144717
   Tabassum R, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033162
   Tanno M, 2007, J BIOL CHEM, V282, P6823, DOI 10.1074/jbc.M609554200
   Timmers S, 2016, DIABETES CARE, V39, P2211, DOI 10.2337/dc16-0499
   Tsalamandris S, 2019, EUR CARDIOL REV, V14, P50, DOI 10.15420/ecr.2018.33.1
   Verma NK, 2004, BRIT J PHARMACOL, V143, P1006, DOI 10.1038/sj.bjp.0706002
   von Frankenberg AD, 2017, EUR J NUTR, V56, P431, DOI 10.1007/s00394-015-1108-6
   Wang RH, 2011, J CLIN INVEST, V121, P4477, DOI 10.1172/JCI46243
   Wang WR, 2013, EXP CELL RES, V319, P1523, DOI 10.1016/j.yexcr.2013.04.007
   Wang Y, 2012, PHARMACOL THERAPEUT, V136, P305, DOI 10.1016/j.pharmthera.2012.08.009
   Wu L, 2012, BBA-MOL BASIS DIS, V1822, P1815, DOI 10.1016/j.bbadis.2012.08.009
   Xiong SQ, 2011, J BIOL CHEM, V286, P5289, DOI 10.1074/jbc.M110.163667
   Xu C, 2013, AM J TRANSL RES, V5, P412
   Yajnik CS, 2008, REV ENDOCR METAB DIS, V9, P203, DOI 10.1007/s11154-008-9087-z
   Yajnik CS, 2012, REV ENDOCR METAB DIS, V13, P121, DOI 10.1007/s11154-012-9214-8
   Yang XD, 2010, MOL CELL BIOL, V30, P2170, DOI 10.1128/MCB.01343-09
   Yeung F, 2004, EMBO J, V23, P2369, DOI 10.1038/sj.emboj.7600244
   Yoshizaki T, 2009, MOL CELL BIOL, V29, P1363, DOI 10.1128/MCB.00705-08
   Yun JM, 2012, J NUTR BIOCHEM, V23, P699, DOI 10.1016/j.jnutbio.2011.03.012
   Zhang CY, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0161792
   Zhao RZ, 2019, INT J MOL MED, V44, P3, DOI 10.3892/ijmm.2019.4188
   Zhou B, 2012, DIABETOLOGIA, V55, P2032, DOI 10.1007/s00125-012-2539-8
   Zhu XY, 2017, NUTR METAB, V14, DOI 10.1186/s12986-017-0217-z
   Zordoky BNM, 2015, BBA-MOL BASIS DIS, V1852, P1155, DOI 10.1016/j.bbadis.2014.10.016
NR 135
TC 43
Z9 44
U1 2
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD AUG
PY 2020
VL 9
IS 8
AR 1882
DI 10.3390/cells9081882
PG 18
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA NL0VK
UT WOS:000567143500001
PM 32796716
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Miettola, J
   Viljanen, AM
AF Miettola, Juhani
   Viljanen, Anna Maria
TI A salutogenic approach to prevention of metabolic syndrome: a mixed
   methods population study
SO SCANDINAVIAN JOURNAL OF PRIMARY HEALTH CARE
LA English
DT Article
DE Finland; general practice; metabolic syndrome; mixed-methods research;
   salutogenesis
ID QUALITY-OF-LIFE; COHERENCE SCALE; ANTONOVSKYS SENSE; HEALTH; PREVALENCE;
   GENDER; ADULTS; RISK
AB Objective. To find a salutogenic approach for prevention of metabolic syndrome in primary care practice. Design. An explanatory sequential mixed-methods procedure was used to fi nd salutogenic approaches for lifestyle change by assessing individual need, potential, and personal motivation. Data from a population health survey and interviews that focused on a sense of coherence were analysed. Subjects. Altogether 480 Finnish subjects participated in a population health survey, and 43 of them were interviewed. The 43 interviewees' data were included in the fi nal analysis. Main outcome measures. With the health survey participants' liability for MetS was assessed, and the objective need for lifestyle intervention was determined. Through the focused interviews potential and personal motivation for lifestyle modifi cation were explored. Finally the data of the 43 interviewed subjects were merged. Results. Four possible lifestyle intervention approaches were identifi ed for specifi c intervention. First, subjects with a strong sense of coherence only need encouragement to maintain a healthy lifestyle; second, professional support was found important for subjects with gaps in health awareness to improve health understanding; third, strengthening of social support for lifestyle change is necessary for subjects with various practical constraints in their everyday life; and fourth, strengthening of stress adaptation is important for subjects with redundant concerns about their health. Conclusions. Salutogenic client-centred lifestyle modifi cation approaches should be part of primary care practice. Further, a cross-disciplinary approach is needed in primary care research and practice to combat the exploding lifestyle illnesses.
C1 [Miettola, Juhani] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
   [Viljanen, Anna Maria] Univ Helsinki, Dept Social Sci Social & Cultural Anthropol, FIN-00014 Helsinki, Finland.
C3 University of Eastern Finland; University of Helsinki
RP Miettola, J (corresponding author), Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
EM juhani.miettola@gmail.com
FU municipality of Lapinlahti; Finnish Cultural Foundation; Development
   Programme for the Prevention and Care of Diabetes in Finland (DEHKO/D2D)
   through the Northern Savo Hospital District
FX The study would not have been possible without the financial support of
   the municipality of Lapinlahti, Finnish Cultural Foundation and the
   Development Programme for the Prevention and Care of Diabetes in Finland
   (DEHKO/D2D) through the Northern Savo Hospital District.
CR [Anonymous], 2009, Motivational interviewing: Preparing people for change
   ANTONOVSKY A, 1993, SOC SCI MED, V36, P725, DOI 10.1016/0277-9536(93)90033-Z
   Antonovsky A., 1987, J NERV MENT DIS, V177, P439
   Antonovsky A., 1979, HLTH STRESS COPING N
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   Eriksson M, 2007, J EPIDEMIOL COMMUN H, V61, P938, DOI 10.1136/jech.2006.056028
   Flensborg-Madsen T, 2005, THESCIENTIFICWORLDJO, V5, P767, DOI 10.1100/tsw.2005.89
   Ford ES, 2004, ENDOCRIN METAB CLIN, V33, P333, DOI 10.1016/j.ecl.2004.03.004
   Frisman GH, 2008, NURS HEALTH SCI, V10, P300, DOI 10.1111/j.1442-2018.2008.00418.x
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Golafshani N., 2003, QUAL REP
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hu G, 2008, J CLIN ENDOCR METAB, V93, P832, DOI 10.1210/jc.2007-1883
   Ilanne-Parikka P, 2004, DIABETES CARE, V27, P2135, DOI 10.2337/diacare.27.9.2135
   Konttinen H, 2008, SOC SCI MED, V66, P2401, DOI 10.1016/j.socscimed.2008.01.053
   Kunitz SJ, 2004, BRIT MED BULL, V69, P61, DOI 10.1093/bmb/ldh015
   Lewis SJ, 2008, INT J CLIN PRACT, V62, P1168, DOI 10.1111/j.1742-1241.2008.01770.x
   Lindström B, 2005, J EPIDEMIOL COMMUN H, V59, P440, DOI 10.1136/jech.2005.034777
   Marquezine GF, 2008, INT J CARDIOL, V129, P259, DOI 10.1016/j.ijcard.2007.07.097
   Miettola J, 2012, CAN J RURAL MED, V17, P10
   O'Cathain A, 2009, J MIX METHOD RES, V3, P3, DOI 10.1177/1558689808326272
   Ochiai R, 2012, HEALTH, V1, P20
   Potter J., 1987, DISCOURSE SOCIAL PSY
   Quinn N., 1987, Culture and cognition. Cultural models in language and thought
   Richards L., 2005, HANDLING QUALITATIVE
   Santos AC, 2008, BMC PUBLIC HEALTH, V8, DOI 10.1186/1471-2458-8-62
   Sintonen H, 2001, ANN MED, V33, P328, DOI 10.3109/07853890109002086
NR 27
TC 10
Z9 12
U1 0
U2 5
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0281-3432
EI 1502-7724
J9 SCAND J PRIM HEALTH
JI Scand. J. Prim. Health Care
PD DEC
PY 2014
VL 32
IS 4
BP 217
EP 225
DI 10.3109/02813432.2014.982372
PG 9
WC Health Care Sciences & Services; Primary Health Care; Medicine, General
   & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine
GA AW2HK
UT WOS:000346108700011
PM 25424465
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ceolotto, G
   De Kreutzenberg, SV
   Cattelan, A
   Fabricio, ASC
   Squarcina, E
   Gion, M
   Semplicini, A
   Fadini, GP
   Avogaro, A
AF Ceolotto, Giulio
   De Kreutzenberg, Saula Vigili
   Cattelan, Arianna
   Fabricio, Aline S. C.
   Squarcina, Elisa
   Gion, Massimo
   Semplicini, Andrea
   Fadini, Gian Paolo
   Avogaro, Angelo
TI Sirtuin 1 stabilization by HuR represses TNF-α-and glucose-induced
   E-selectin release and endothelial cell adhesiveness in vitro:
   relevance to human metabolic syndrome
SO CLINICAL SCIENCE
LA English
DT Article
DE cell adhesion; diabetes; endothelial dysfunction; inflammation;
   metabolic syndrome; transcription factor
ID SOLUBLE E-SELECTIN; INTERCELLULAR-ADHESION MOLECULE-1; HIGH SERUM
   CONCENTRATIONS; PROTEIN-KINASE-C; KAPPA-B; OXIDATIVE STRESS; ENHANCES
   ICAM-1; EXPRESSION; VCAM-1; RESVERATROL
AB Chronic inflammation and hyperglycaemia, typical features of metabolic diseases, trigger endothelial damage and release of E-selectin, a marker of endothelial activation. In the present study, we investigated molecular pathways involved in the regulation of endothelial cell activation induced by tumour necrosis factor-alpha (TNF-alpha) and high glucose. In cultured human umbilical vein endothelial cells (HUVECs), we studied the role of HuR, an ELAV (embryonic lethal, abnormal vision, Drosophila) family RNA-binding protein, and Sirtuin 1 (SIRT1) on E-selectin release and cell adhesion at different glucose concentrations. HuR expression and binding to SIRT1 were also analysed ex vivo in peripheral blood mononuclear cells (PBMCs) of subjects with and without the metabolic syndrome (MS), by immunoprecipitation (IP) of the ribonucleoprotein (RNP) complex. We found that SIRT1 overexpression prevented TNF-alpha- and high-glucose-dependent nuclear factor-kappa B (NF-kappa B)-p65 acetylation, E-selectin promoter activity, E-selectin release and adhesion of THP-1 cells to HUVECs. The same was mimicked by HuR overexpression, which binds and stabilizes SIRT1 mRNA. Importantly, in PBMCs of individuals with MS compared with those without, SIRT1 expression was lower, and the ability of HuR to bind SIRT1 mRNA was significantly reduced, while plasma E-selectin was increased. We conclude that post-transcriptional stabilization of SIRT1 by HuR represses inflammation- and hyperglycaemia-induced E-selectin release and endothelial cell activation. Therefore, increasing SIRT1 expression represents a strategy to counter the accelerated vascular disease in metabolic disorders.
C1 [Ceolotto, Giulio; De Kreutzenberg, Saula Vigili; Cattelan, Arianna; Semplicini, Andrea; Fadini, Gian Paolo; Avogaro, Angelo] Univ Padua, Dept Med DIMED, Padua, Italy.
   [Fabricio, Aline S. C.; Squarcina, Elisa; Gion, Massimo] ULSS 12, Reg Ctr Diagnost Prognost & Predict Biomarkers, Dept Clin Pathol, Venice, Italy.
C3 University of Padua; ULSS 3 Serenissima
RP Avogaro, A (corresponding author), Univ Padua, Dept Med DIMED, Padua, Italy.
EM angelo.avogaro@unipd.it
RI de Kreutzenberg, S./AAA-4277-2022; Avogaro, Angelo/S-3808-2016; Fadini,
   Gian/M-4575-2019; Fabricio, Aline/H-3121-2011; Gion,
   Massimo/J-8716-2018; CATTELAN, ANNA/AAL-3654-2020; Semplicini,
   Andrea/B-5959-2013
OI Fabricio, Aline/0000-0003-0153-8809; FADINI, GIAN
   PAOLO/0000-0002-6510-2097; Ceolotto, Giulio/0000-0002-4687-8033;
   Semplicini, Andrea/0000-0003-0652-0739; AVOGARO,
   ANGELO/0000-0002-1177-0516; Cattelan, Anna Maria/0000-0003-2869-2945
CR Albertini JP, 1998, DIABETES CARE, V21, P1008, DOI 10.2337/diacare.21.6.1008
   Boyle EM, 1998, CIRCULATION, V98, pII282
   Brennan CM, 2001, CELL MOL LIFE SCI, V58, P266, DOI 10.1007/PL00000854
   Ceolotto G, 2004, DIABETES, V53, P1344, DOI 10.2337/diabetes.53.5.1344
   CHEN CC, 1995, J IMMUNOL, V155, P3538
   COMINACINI L, 1995, DIABETOLOGIA, V38, P1122
   Csiszar A, 2008, AM J PHYSIOL-HEART C, V294, pH2721, DOI 10.1152/ajpheart.00235.2008
   Cuneo AA, 2010, J MOL CELL CARDIOL, V49, P647, DOI 10.1016/j.yjmcc.2010.04.016
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   DAVIES MJ, 1993, J PATHOL, V171, P223, DOI 10.1002/path.1711710311
   de Kreutzenberg SV, 2010, DIABETES, V59, P1006, DOI 10.2337/db09-1187
   DEISHER TA, 1993, BIOCHEM BIOPH RES CO, V193, P1283, DOI 10.1006/bbrc.1993.1764
   Doller A, 2008, CELL SIGNAL, V20, P2165, DOI 10.1016/j.cellsig.2008.05.007
   Edelstein LC, 2005, J BIOL CHEM, V280, P11192, DOI 10.1074/jbc.M412997200
   Ersanli D, 2007, SCAND J CLIN LAB INV, V67, P474, DOI 10.1080/00365510601110148
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   Gillum MP, 2011, DIABETES, V60, P3235, DOI 10.2337/db11-0616
   Glass CK, 2012, CELL METAB, V15, P635, DOI 10.1016/j.cmet.2012.04.001
   Higai K, 2006, CLIN CHIM ACTA, V367, P137, DOI 10.1016/j.cca.2005.12.008
   Hwang SJ, 1997, CIRCULATION, V96, P4219
   Iori E, 2008, LIFE SCI, V82, P383, DOI 10.1016/j.lfs.2007.11.021
   Kado S, 1999, DIABETES RES CLIN PR, V46, P143, DOI 10.1016/S0168-8227(99)00083-2
   Kao CL, 2010, J ATHEROSCLER THROMB, V17, P970, DOI 10.5551/jat.4333
   Katsanou V, 2005, MOL CELL, V19, P777, DOI 10.1016/j.molcel.2005.08.007
   Kim HH, 2008, CELL CYCLE, V7, P3371
   Kwon HS, 2008, TRENDS BIOCHEM SCI, V33, P517, DOI 10.1016/j.tibs.2008.08.001
   Lopes-Virella MF, 2008, DIABETES CARE, V31, P2006, DOI 10.2337/dc08-0659
   Matsumoto K, 2000, ATHEROSCLEROSIS, V152, P415, DOI 10.1016/S0021-9150(99)00487-6
   Matsumoto K, 2002, METABOLISM, V51, P932, DOI 10.1053/meta.2002.33354
   Milne JC, 2007, NATURE, V450, P712, DOI 10.1038/nature06261
   Narumi S, 2001, NEPHRON, V89, P161, DOI 10.1159/000046063
   Natarajan A, 2011, DIABETIC MED, V28, P1201, DOI 10.1111/j.1464-5491.2011.03311.x
   Piconi L, 2004, J THROMB HAEMOST, V2, P1453, DOI 10.1111/j.1538-7836.2004.00835.x
   Pullmann R, 2005, J BIOL CHEM, V280, P22819, DOI 10.1074/jbc.M501106200
   Quagliaro L, 2005, ATHEROSCLEROSIS, V183, P259, DOI 10.1016/j.atherosclerosis.2005.03.015
   Read MA, 1997, J BIOL CHEM, V272, P2753, DOI 10.1074/jbc.272.5.2753
   Rhee WJ, 2010, P NATL ACAD SCI USA, V107, P6858, DOI 10.1073/pnas.1000444107
   RICHARDSON M, 1994, ARTERIOSCLER THROMB, V14, P760, DOI 10.1161/01.ATV.14.5.760
   Rupin A, 2004, CARDIOVASC RES, V63, P323, DOI 10.1016/j.cardiores.2004.03.018
   Soedamah-Muthu SS, 2006, J DIABETES COMPLICAT, V20, P188, DOI 10.1016/j.jdiacomp.2005.06.005
   Stein S, 2011, CELL CYCLE, V10, P640, DOI 10.4161/cc.10.4.14863
   Troseid M, 2005, SCAND J CLIN LAB INV, V65, P283, DOI 10.1080/00365510510013811
   Vannini N, 2008, CURR PHARM DESIGN, V14, P221
   Yang JH, 2011, ARCH MED RES, V42, P354, DOI 10.1016/j.arcmed.2011.07.005
   Yang JH, 2010, ENDOCRINE, V37, P365, DOI 10.1007/s12020-010-9314-8
   Yeung F, 2004, EMBO J, V23, P2369, DOI 10.1038/sj.emboj.7600244
   Yoshizaki T, 2010, AM J PHYSIOL-ENDOC M, V298, pE419, DOI 10.1152/ajpendo.00417.2009
   Yu GY, 2005, BLOOD, V105, P3545, DOI 10.1182/blood-2004-07-2617
   Zhang HR, 2009, ARTERIOSCL THROM VAS, V29, P1164, DOI 10.1161/ATVBAHA.109.187146
   Zhang QJ, 2008, CARDIOVASC RES, V80, P191, DOI 10.1093/cvr/cvn224
NR 50
TC 36
Z9 43
U1 0
U2 22
PU PORTLAND PRESS LTD
PI LONDON
PA 5TH FLR, 90 HIGH HOLBORN, LONDON WC1V 6LJ, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD OCT
PY 2014
VL 127
IS 7-8
BP 449
EP 461
DI 10.1042/CS20130439
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AQ1FD
UT WOS:000342526400003
PM 24702436
DA 2025-06-11
ER

PT J
AU Kawarazaki, W
   Fujita, T
AF Kawarazaki, Wakako
   Fujita, Toshiro
TI Aberrant Rac1-mineralocorticoid receptor pathways in salt-sensitive
   hypertension
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article
DE aldosterone; aldosterone-releasing factors; kidney; metabolic syndrome;
   mineralocorticoid receptor; obesity; Rac1; salt sensitivity of blood
   pressure; salt-sensitive hypertension
ID ACTIVATED PROTEIN-KINASE; JUN NH2-TERMINAL KINASE; MINERALOCORTICOID
   RECEPTOR; ANGIOTENSIN-II; BLOOD-PRESSURE; INTRACEREBROVENTRICULAR
   INFUSION; METABOLIC SYNDROME; OXIDATIVE STRESS; RAC1 GTPASE; WEIGHT-LOSS
AB According to Guyton's model, impaired renal sodium excretion plays a key role in the increased salt sensitivity of blood pressure (BP). Several factors contribute to impaired renal sodium excretion, including the sympathetic nervous system, the renin-angiotensin system and aldosterone. Accumulating evidence suggests that abnormalities in aldosterone and its receptor (i.e. the mineralocorticoid receptor (MR)) are involved in the development of salt-sensitive (SS) hypertension.
   Patients with metabolic syndrome often exhibit hyperaldosteronism and are susceptible to SS hypertension. Aldosterone secretion from the adrenal glands is not suppressed in obese hypertensive rats fed a high-salt diet because of the abundant production of adipocyte-derived aldosterone-releasing factors, which are independent of the negative feedback regulation of aldosterone secretion by the renin-angiotensin-aldosterone system. Increased plasma aldosterone levels lead to SS hypertension via MR activation in the kidney.
   Renal MR activity is increased in Dahl salt-sensitive rats fed a high-salt diet, despite the appropriate suppression of plasma aldosterone levels. In this rat strain, activation of MR in the distal nephron causes salt-induced hypertension. This paradoxical response of the MR to salt loading can be attributed to activation of Rac1, a small GTPase. In the presence of aldosterone, activated Rac1 synergistically and directly activates MR in a ligand-independent manner. Thus, Rac1 activation in the kidney determines the salt sensitivity of BP. Together, the available evidence suggests that the aberrant Rac1-MR pathway plays a key role in the development of SS hypertension.
C1 [Kawarazaki, Wakako; Fujita, Toshiro] Univ Tokyo 1, Div Clin Epigenet, Res Ctr Adv Sci & Technol 1, Tokyo 1538904, Japan.
RP Fujita, T (corresponding author), Univ Tokyo, Div Clin Epigenet, Res Ctr Adv Sci & Technol, Meguro Ku, 4-6-1 Komaba, Tokyo 1538904, Japan.
EM Toshiro.FUJITA@rcast.u-tokyo.ac.jp
RI Kawarazaki, Wakako/GPP-2721-2022; Kawarazaki, Wakako/LIG-5150-2024
OI Kawarazaki, Wakako/0000-0002-1332-8537
FU Japan Society for the promotion of Science [21229012]; Research Project
   Japan Science and Technology Agency (JST); CREST; Grants-in-Aid for
   Scientific Research [21229012, 24659410] Funding Source: KAKEN
FX The authors' work reported herein was supported by a Grant-in-Aid for
   Scientific Research from the Japan Society for the promotion of Science
   (No. 21229012), as well as grants from the Research Project Japan
   Science and Technology Agency (JST), Strategic Basic Research Programs
   and CREST. The authors thank Inter-Biotec (http://www.interbiotec.com/)
   for the English language editing of this paper.
CR Aikawa R, 2001, BIOCHEM BIOPH RES CO, V289, P901, DOI 10.1006/bbrc.2001.6068
   Akilesh S, 2011, J CLIN INVEST, V121, P4127, DOI 10.1172/JCI46458
   Barone I, 2011, JNCI-J NATL CANCER I, V103, P538, DOI 10.1093/jnci/djr058
   Bentley-Lewis R, 2007, J CLIN ENDOCR METAB, V92, P4472, DOI 10.1210/jc.2007-1088
   BRILLA CG, 1993, J MOL CELL CARDIOL, V25, P563, DOI 10.1006/jmcc.1993.1066
   Chen J, 2009, LANCET, V373, P829, DOI 10.1016/S0140-6736(09)60144-6
   Crowley SD, 2006, P NATL ACAD SCI USA, V103, P17985, DOI 10.1073/pnas.0605545103
   DAHL LK, 1974, CIRC RES, V34, P94, DOI 10.1161/01.RES.34.1.94
   de Paula RB, 2004, HYPERTENSION, V43, P41, DOI 10.1161/01.HYP.0000105624.68174.00
   DENNER LA, 1990, SCIENCE, V250, P1740, DOI 10.1126/science.2176746
   Ehrhart-Bornstein M, 2003, P NATL ACAD SCI USA, V100, P14211, DOI 10.1073/pnas.2336140100
   Engeli S, 2005, HYPERTENSION, V45, P356, DOI 10.1161/01.HYP.0000154361.47683.d3
   Francis J, 2001, AM J PHYSIOL-HEART C, V281, pH2241, DOI 10.1152/ajpheart.2001.281.5.H2241
   Frost JA, 2000, J BIOL CHEM, V275, P19693, DOI 10.1074/jbc.M909860199
   FUJITA T, 1980, AM J MED, V69, P334, DOI 10.1016/0002-9343(80)90002-9
   FUKAMIZU A, 1993, J BIOL CHEM, V268, P11617
   Funder JW, 2005, HEART FAIL REV, V10, P15, DOI 10.1007/s10741-005-2344-2
   Gee HY, 2013, J CLIN INVEST, V123, P3243, DOI 10.1172/JCI69134
   GOMEZSANCHEZ EP, 1986, ENDOCRINOLOGY, V118, P819, DOI 10.1210/endo-118-2-819
   GOMEZSANCHEZ EP, 1990, AM J PHYSIOL, V258, pE649, DOI 10.1152/ajpendo.1990.258.4.E649
   Goodfriend TL, 2004, HYPERTENSION, V43, P358, DOI 10.1161/01.HYP.0000113294.06704.64
   Gupta IR, 2013, J MED GENET, V50, P330, DOI 10.1136/jmedgenet-2012-101442
   Gurley SB, 2011, CELL METAB, V13, P469, DOI 10.1016/j.cmet.2011.03.001
   GUYTON AC, 1992, HYPERTENSION, V19, pI2, DOI 10.1161/01.HYP.19.1_Suppl.I2
   Heasman SJ, 2008, NAT REV MOL CELL BIO, V9, P690, DOI 10.1038/nrm2476
   Huang BS, 2009, AM J PHYSIOL-REG I, V296, pR994, DOI 10.1152/ajpregu.90903.2008
   Jin S, 2008, AM J PHYSIOL-GASTR L, V294, pG928, DOI 10.1152/ajpgi.00219.2007
   Kawarazaki W, 2012, J AM SOC NEPHROL, V23, P997, DOI 10.1681/ASN.2011070734
   Kawashima T, 2006, J CELL BIOL, V175, P937, DOI 10.1083/jcb.200604073
   Kidambi S, 2007, HYPERTENSION, V49, P704, DOI 10.1161/01.HYP.0000253258.36141.c7
   Kobori H, 2003, HYPERTENSION, V41, P592, DOI 10.1161/01.HYP.0000056768.03657.B4
   Krug AW, 2010, HYPERTENSION, V55, P1476, DOI 10.1161/HYPERTENSIONAHA.109.148783
   Lambers Heerspink HJ, 2012, NEPHROL DIAL TRANSPL, V27, P3435, DOI 10.1093/ndt/gfs354
   Levy DG, 2004, J CLIN ENDOCR METAB, V89, P2736, DOI 10.1210/jc.2003-032149
   Lezoualc'h F, 2008, J MOL CELL CARDIOL, V44, P623, DOI 10.1016/j.yjmcc.2008.01.011
   Lin S, 2010, J RENIN-ANGIO-ALDO S, V11, P149, DOI 10.1177/1470320310369603
   Luft FC, 1997, AM J CLIN NUTR, V65, P612
   Matsui H, 2008, HYPERTENSION, V52, P287, DOI 10.1161/HYPERTENSIONAHA.108.111815
   McCurley A, 2012, NAT MED, V18, P1429, DOI 10.1038/nm.2891
   McCurley A, 2012, MOL CELL ENDOCRINOL, V350, P256, DOI 10.1016/j.mce.2011.06.014
   MIALL WE, 1963, BRIT MED J, P75
   Mihailidou AS, 2009, HYPERTENSION, V54, P1306, DOI 10.1161/HYPERTENSIONAHA.109.136242
   Mu S, 2011, NAT MED, V17, P573, DOI 10.1038/nm.2337
   Mundel P, 2010, KIDNEY INT, V77, P571, DOI 10.1038/ki.2009.424
   Nagase M, 2007, HYPERTENSION, V50, P877, DOI 10.1161/HYPERTENSIONAHA.107.091058
   Nagase M, 2006, J AM SOC NEPHROL, V17, P3438, DOI 10.1681/ASN.2006080944
   Nagase M, 2012, HYPERTENSION, V59, P500, DOI 10.1161/HYPERTENSIONAHA.111.185520
   Nagase M, 2006, HYPERTENSION, V47, P1084, DOI 10.1161/01.HYP.0000222003.28517.99
   Nishida M, 2005, J BIOL CHEM, V280, P18434, DOI 10.1074/jbc.M409710200
   Oishi T, 2010, J RECEPT SIG TRANSD, V30, P484, DOI 10.3109/10799893.2010.505240
   Papaharalambus C, 2005, J BIOL CHEM, V280, P18790, DOI 10.1074/jbc.M410081200
   Penner SB, 2007, CAN J CARDIOL, V23, P567
   Rickard AJ, 2009, HYPERTENSION, V54, P537, DOI 10.1161/HYPERTENSIONAHA.109.131110
   ROCCHINI AP, 1989, NEW ENGL J MED, V321, P580, DOI 10.1056/NEJM198908313210905
   Rocha R, 1998, HYPERTENSION, V31, P451, DOI 10.1161/01.HYP.31.1.451
   Rossi GP, 2008, J CLIN ENDOCR METAB, V93, P2566, DOI 10.1210/jc.2008-0251
   SANCHEZ EPG, 1988, J HYPERTENS, V6, P437, DOI 10.1097/00004872-198806000-00002
   Satoh M, 2006, P NATL ACAD SCI USA, V103, P7432, DOI 10.1073/pnas.0510444103
   Schmitz U, 2001, J BIOL CHEM, V276, P22003, DOI 10.1074/jbc.M102450200
   Schuringa JJ, 2001, J BIOL CHEM, V276, P27709, DOI 10.1074/jbc.M009821200
   Shibata S, 2007, HYPERTENSION, V49, P355, DOI 10.1161/01.HYP.0000255636.11931.a2
   Shibata S, 2011, J CLIN INVEST, V121, P3233, DOI 10.1172/JCI43124
   Shibata S, 2008, NAT MED, V14, P1370, DOI 10.1038/nm.1879
   Simon AR, 2000, SCIENCE, V290, P144, DOI 10.1126/science.290.5489.144
   Takemoto M, 2001, J CLIN INVEST, V108, P1429, DOI 10.1172/JCI13350
   Usher MG, 2010, J CLIN INVEST, V120, P3350, DOI 10.1172/JCI41080
   Weigel Nancy L, 2007, Nucl Recept Signal, V5, pe005
   Welsh GI, 2012, NAT REV NEPHROL, V8, P14, DOI 10.1038/nrneph.2011.151
   Wong GW, 2004, P NATL ACAD SCI USA, V101, P10302, DOI 10.1073/pnas.0403760101
   Wu XM, 2008, CELL, V133, P340, DOI 10.1016/j.cell.2008.01.052
   Yokota K, 2007, J BIOL CHEM, V282, P1998, DOI 10.1074/jbc.M607741200
   Zhang ZH, 2006, HYPERTENSION, V48, P127, DOI 10.1161/01.HYP.0000224296.96235.dd
NR 72
TC 17
Z9 17
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1870
EI 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD DEC
PY 2013
VL 40
IS 12
BP 929
EP 936
DI 10.1111/1440-1681.12177
PG 8
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 254HY
UT WOS:000327157000013
PM 24111570
DA 2025-06-11
ER

PT J
AU García-Sánchez, C
   Torres-Tamayo, M
   Juarez-Meavepeña, M
   López-Osorio, C
   Toledo-Ibelles, P
   Monter-Garrido, M
   Cruz-Robles, D
   Carreon-Torres, E
   Vargas-Alarcón, G
   Pérez-Méndez, O
AF Garcia-Sanchez, Cynthia
   Torres-Tamayo, Margarita
   Juarez-Meavepena, Minerva
   Lopez-Osorio, Cristhel
   Toledo-Ibelles, Paola
   Monter-Garrido, Mariana
   Cruz-Robles, David
   Carreon-Torres, Elizabeth
   Vargas-Alarcon, Gilberto
   Perez-Mendez, Oscar
TI Lipid plasma concentrations of HDL subclasses determined by enzymatic
   staining on polyacrylamide electrophoresis gels in children with
   metabolic syndrome
SO CLINICA CHIMICA ACTA
LA English
DT Article
DE High-density lipoproteins; Metabolic syndrome; Dyslipidemia; HDL
   subclasses; Coronary heart disease; Pediatric patients
ID HIGH-DENSITY-LIPOPROTEIN; ELEVATED OXIDATIVE STRESS; INSULIN-RESISTANCE;
   SYNDROME VARIABLES; CHOLESTEROL; ADOLESCENTS; PARTICLES; ABNORMALITIES;
   OVERWEIGHT; CHILDHOOD
AB Background: The antiatherogenic role of different HDL subclasses is still controversial. HDL particles of the same size can have different lipid contents in some physiopathological situations. However, little is known about the plasma lipid levels of HDL subclasses when they are separated by their hydrodynamic diameter.
   Methods: Triglycerides (Tg), phosphatidylcholine (Ph), and cholesterol (C) plasma concentrations of HDL subclasses, were determined by enzymatic staining on polyacrylamide gradient gel (PAGE) in 50 pediatric patients with metabolic syndrome (MS), and 50 control children paired by age and gender. Proteins of HDL subclasses were also stained for the assessment of the relative size distribution of HDL.
   Results: Relative HDL size distribution was shifted to small particles in MS pediatric patients when determined per protein. In contrast, cholesterol plasma concentrations corresponding to the HDL2b, 2a, 3a, and 3b subclasses were decreased: triglycerides of HDL3b and 3c, as well as plasma phospholipids from HDL3c, were elevated in MS patients as compared to controls. The C-to-Ph ratio, considered as indicative of HDL composition, was similar among the 5 HDL subclasses in control subjects, whereas this ratio gradually decreased from large HDL2b to small HDL3c in the MS group. Cholesterol plasma concentrations of HDL subclasses correlated with the components of the MS.
   Conclusions: Lipids of HDL subclasses provide more and accurate information than the relative HDL size distribution determined by protein staining, and may contribute to understand better HDL metabolism and the coronary risk associated to these lipoproteins. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Garcia-Sanchez, Cynthia; Juarez-Meavepena, Minerva; Lopez-Osorio, Cristhel; Toledo-Ibelles, Paola; Monter-Garrido, Mariana; Cruz-Robles, David; Carreon-Torres, Elizabeth; Vargas-Alarcon, Gilberto; Perez-Mendez, Oscar] Inst Nacl Cardiol Ignacio Chavez, Dept Mol Biol, Mexico City 14080, DF, Mexico.
   [Torres-Tamayo, Margarita] Gen Hosp Manuel Gea Gonzalez, Obes Clin, Mexico City, DF, Mexico.
C3 National Institute of Cardiology - Mexico
RP Pérez-Méndez, O (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Mol Biol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
EM opmendez@yahoo.com
RI Pérez-Méndez, Oscar/AAJ-8451-2020; Vargas-Alarcon,
   Gilberto/AEW-0446-2022; Cruz-Robles, David/C-7278-2015
OI Garcia-Sanchez, Cynthia/0000-0003-3521-6955; Vargas-Alarcon,
   Gilberto/0000-0001-7916-5163; Torres-Tamayo,
   Margarita/0000-0002-5655-0875; Carreon-Torres,
   Elizabeth/0000-0003-3600-249X; Cruz-Robles, David/0000-0003-4234-9561
FU CONACYT [102137]
FX We thank Alin Quiroz for her technical contribution. This study was
   partially supported by the CONACYT Grant No. 102137.
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   BLANCHE PJ, 1981, BIOCHIM BIOPHYS ACTA, V665, P408, DOI 10.1016/0005-2760(81)90253-8
   Escolà-Gil JC, 2009, ATHEROSCLEROSIS, V206, P321, DOI 10.1016/j.atherosclerosis.2008.12.044
   Carreón-Torres E, 2005, ATHEROSCLEROSIS, V181, P233, DOI 10.1016/j.atherosclerosis.2004.12.047
   CASTRO GR, 1988, BIOCHEMISTRY-US, V27, P25, DOI 10.1021/bi00401a005
   Chen W, 2007, AM J EPIDEMIOL, V166, P527, DOI 10.1093/aje/kwm105
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Davidson WS, 2009, ARTERIOSCL THROM VAS, V29, P870, DOI 10.1161/ATVBAHA.109.186031
   de Ferranti SD, 2006, CLIN CHEM, V52, P1325, DOI 10.1373/clinchem.2006.067181
   DELONG DM, 1986, JAMA-J AM MED ASSOC, V256, P2372, DOI 10.1001/jama.256.17.2372
   Elkhalil L, 1997, METABOLISM, V46, P474, DOI 10.1016/S0026-0495(97)90180-3
   Festa A, 2005, CIRCULATION, V111, P3465, DOI 10.1161/CIRCULATIONAHA.104.512079
   Florentin M, 2008, CURR OPIN CARDIOL, V23, P370, DOI 10.1097/HCO.0b013e3283043806
   Garvey WT, 2003, DIABETES, V52, P453, DOI 10.2337/diabetes.52.2.453
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Hedley AA, 2004, JAMA-J AM MED ASSOC, V291, P2847, DOI 10.1001/jama.291.23.2847
   Huesca C, 2004, ATHEROSCLEROSIS SUPP, V5, P65
   Huesca-Gómez C, 2004, ENDOCR RES, V30, P403, DOI 10.1081/ERC-200035433
   Huesca-Gómez C, 2002, METABOLISM, V51, P443, DOI 10.1053/meta.2002.31323
   Kimura T, 2010, J BIOL CHEM, V285, P4387, DOI 10.1074/jbc.M109.043869
   Kontush A, 2005, ATHEROSCLEROSIS, V182, P277, DOI 10.1016/j.atherosclerosis.2005.03.001
   Kontush A, 2003, ARTERIOSCL THROM VAS, V23, P1881, DOI 10.1161/01.ATV.0000091338.93223.E8
   Kontush A, 2006, PHARMACOL REV, V58, P342, DOI 10.1124/pr.58.3.1
   Linsel-Nitschke P, 2009, LIPIDS HEALTH DIS, V8, DOI 10.1186/1476-511X-8-14
   Magkos F, 2008, INT J OBESITY, V32, P1655, DOI 10.1038/ijo.2008.164
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Medina-Urrutia A, 2008, ATHEROSCLEROSIS, V201, P392, DOI 10.1016/j.atherosclerosis.2008.02.029
   Miranda PJ, 2005, AM HEART J, V149, P33, DOI 10.1016/j.ahj.2004.07.013
   Morgan John, 2004, Curr Atheroscler Rep, V6, P359
   Nguyen QM, 2008, DIABETES CARE, V31, P2044, DOI 10.2337/dc08-0898
   Nobécourt E, 2005, DIABETOLOGIA, V48, P529, DOI 10.1007/s00125-004-1655-5
   Otvos JD, 2006, CIRCULATION, V113, P1556, DOI 10.1161/CIRCULATIONAHA.105.565135
   Pérez-Méndez O, 2007, CLIN CHIM ACTA, V376, P17, DOI 10.1016/j.cca.2006.07.003
   Rye KA, 2000, J LIPID RES, V41, P1640
   Sorof J, 2002, HYPERTENSION, V40, P441, DOI 10.1161/01.HYP.0000032940.33466.12
   Sorof JM, 2004, PEDIATRICS, V113, P475, DOI 10.1542/peds.113.3.475
   Srinivasan SR, 2006, HYPERTENSION, V48, P33, DOI 10.1161/01.HYP.0000226410.11198.f4
   Tian L, 2008, CLIN CHIM ACTA, V388, P148, DOI 10.1016/j.cca.2007.10.028
   Toledo-Ibelles P, 2010, J LIPID RES, V51, P1610, DOI 10.1194/jlr.D004358
   Warnick GR, 2006, CLIN LAB MED, V26, P803, DOI 10.1016/j.cll.2006.07.005
   WILLIAMS PT, 1990, J LIPID RES, V31, P1131
   Xu YH, 2003, CLIN CHIM ACTA, V332, P95, DOI 10.1016/S0009-8981(03)00138-4
   Zimmet P, 2007, PEDIATR DIABETES, V8, P299, DOI 10.1111/j.1399-5448.2007.00271.x
NR 44
TC 25
Z9 26
U1 0
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD JAN 30
PY 2011
VL 412
IS 3-4
BP 292
EP 298
DI 10.1016/j.cca.2010.10.021
PG 7
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 718IV
UT WOS:000287115400014
PM 21036160
DA 2025-06-11
ER

PT J
AU Gomez, JA
   Rutkowski, DT
AF Gomez, Javier A.
   Rutkowski, D. Thomas
TI Experimental reconstitution of chronic ER stress in the liver reveals
   feedback suppression of BiP mRNA expression
SO ELIFE
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; PROGRAMMED
   CELL-DEATH; LIPID-METABOLISM; LEPTIN RECEPTOR; GENE-EXPRESSION; LINKS
   OBESITY; MOUSE MODEL; IRE1; ATF6
AB Endoplasmic reticulum (ER) stress is implicated in many chronic diseases, but very little is known about how the unfolded protein response (UPR) responds to persistent ER stress in vivo. Here, we experimentally reconstituted chronic ER stress in the mouse liver, using repeated injection of a low dose of the ER stressor tunicamycin. Paradoxically, this treatment led to feedback-mediated suppression of a select group of mRNAs, including those encoding the ER chaperones BiP and GRP94. This suppression was due to both silencing of the ATF6a pathway of UPR-dependent transcription and enhancement of mRNA degradation, possibly via regulated IRE1-dependent decay (RIDD). The suppression of mRNA encoding BiP was phenocopied by ectopic overexpression of BiP protein, and was also observed in obese mice. Our findings suggest that persistent cycles of UPR activation and deactivation create an altered, quasi-stable setpoint for UPR-dependent transcriptional regulationan outcome that could be relevant to conditions such as metabolic syndrome.
C1 [Gomez, Javier A.] Univ Iowa, Carver Coll Med, Grad Program Mol & Cellular Biol, Iowa City, IA USA.
   [Rutkowski, D. Thomas] Univ Iowa, Dept Anat & Cell Biol, Carver Coll Med, Iowa City, IA 52242 USA.
   [Rutkowski, D. Thomas] Univ Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA.
C3 University of Iowa; University of Iowa; University of Iowa
RP Rutkowski, DT (corresponding author), Univ Iowa, Dept Anat & Cell Biol, Carver Coll Med, Iowa City, IA 52242 USA.; Rutkowski, DT (corresponding author), Univ Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA.
EM thomas-rutkowski@uiowa.edu
OI Rutkowski, Thomas/0000-0001-6586-4449
FU National Institute of General Medical Sciences [GM115424, GM067795]
FX National Institute of General Medical Sciences GM115424 D Thomas
   RutkowskiNational Institute of General Medical Sciences GM067795 Javier
   A GomezThe funders had no role in study design, data collection and
   interpretation, or the decision to submit the work for publication.
CR Arensdorf Angela M., 2013, Frontiers in Genetics, V4, P256, DOI 10.3389/fgene.2013.00256
   Arensdorf Angela M., 2013, Frontiers in Genetics, V4, P188, DOI 10.3389/fgene.2013.00188
   Arensdorf AM, 2013, J CELL SCI, V126, P4026, DOI 10.1242/jcs.130757
   Bertolotti A, 2000, NAT CELL BIOL, V2, P326, DOI 10.1038/35014014
   Bright MD, 2015, MOL CELL BIOL, V35, P2186, DOI 10.1128/MCB.00013-15
   Calfon M, 2002, NATURE, V415, P92, DOI 10.1038/415092a
   CAMPFIELD LA, 1995, SCIENCE, V269, P546, DOI 10.1126/science.7624778
   Chambers JE, 2012, J CELL BIOL, V198, P371, DOI 10.1083/jcb.201202005
   Chen H, 1996, CELL, V84, P491, DOI 10.1016/S0092-8674(00)81294-5
   Chikka MR, 2013, J BIOL CHEM, V288, P4405, DOI 10.1074/jbc.M112.432344
   Cinaroglu A, 2011, HEPATOLOGY, V54, P495, DOI 10.1002/hep.24396
   Cretenet G, 2010, CELL METAB, V11, P47, DOI 10.1016/j.cmet.2009.11.002
   Dan H, 2008, BIOCHEM BIOPH RES CO, V365, P777, DOI 10.1016/j.bbrc.2007.11.040
   Ezzati M, 2002, LANCET, V360, P1347, DOI 10.1016/S0140-6736(02)11403-6
   Fan CG, 2004, J CLIN INVEST, V113, P746, DOI 10.1172/JCI200417337
   Foufelle F, 2016, PHARMACOL RES PERSPE, V4, DOI 10.1002/prp2.211
   Gardner BM, 2013, CSH PERSPECT BIOL, V5, DOI 10.1101/cshperspect.a013169
   Gardner BM, 2011, SCIENCE, V333, P1891, DOI 10.1126/science.1209126
   Gething MJ, 1999, SEMIN CELL DEV BIOL, V10, P465, DOI 10.1006/scdb.1999.0318
   Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
   HALAAS JL, 1995, SCIENCE, V269, P543, DOI 10.1126/science.7624777
   Han D, 2009, CELL, V138, P562, DOI 10.1016/j.cell.2009.07.017
   Harding HP, 1999, NATURE, V397, P271, DOI 10.1038/16729
   Harding HP, 2000, MOL CELL, V6, P1099, DOI 10.1016/S1097-2765(00)00108-8
   Hollien J, 2006, SCIENCE, V313, P104, DOI 10.1126/science.1129631
   Hollien J, 2009, J CELL BIOL, V186, P323, DOI 10.1083/jcb.200903014
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   Iwakoshi NN, 2003, NAT IMMUNOL, V4, P321, DOI 10.1038/ni907
   Ji C, 2011, HEPATOLOGY, V54, P229, DOI 10.1002/hep.24368
   Kaser A, 2013, SEMIN IMMUNOPATHOL, V35, P307, DOI 10.1007/s00281-013-0377-5
   Kawasaki K, 2015, J BIOL CHEM, V290, P3639, DOI 10.1074/jbc.M114.592139
   Kimata Y, 2004, J CELL BIOL, V167, P445, DOI 10.1083/jcb.200405153
   Lee AH, 2003, MOL CELL BIOL, V23, P7448, DOI 10.1128/MCB.23.21.7448-7459.2003
   Lee AH, 2005, EMBO J, V24, P4368, DOI 10.1038/sj.emboj.7600903
   Lee GH, 1996, NATURE, V379, P632, DOI 10.1038/379632a0
   Lee K, 2002, GENE DEV, V16, P452, DOI 10.1101/gad.964702
   Lerner AG, 2012, CELL METAB, V16, P250, DOI 10.1016/j.cmet.2012.07.007
   Lin JH, 2007, SCIENCE, V318, P944, DOI 10.1126/science.1146361
   Malhi H, 2011, J HEPATOL, V54, P795, DOI 10.1016/j.jhep.2010.11.005
   Marciniak SJ, 2004, GENE DEV, V18, P3066, DOI 10.1101/gad.1250704
   Maurel M, 2014, TRENDS BIOCHEM SCI, V39, P245, DOI 10.1016/j.tibs.2014.02.008
   Muse GW, 2007, NAT GENET, V39, P1507, DOI 10.1038/ng.2007.21
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   OLDEN K, 1979, P NATL ACAD SCI USA, V76, P791, DOI 10.1073/pnas.76.2.791
   Oyadomari S, 2008, CELL METAB, V7, P520, DOI 10.1016/j.cmet.2008.04.011
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Ozean U, 2008, MOL CELL, V29, P541, DOI [10.1016/j.moicel.2007.12.023, 10.1016/j.molcel.2007.12.023]
   PATTERSON SI, 1995, METHOD ENZYMOL, V250, P284
   PELLEYMOUNTER MA, 1995, SCIENCE, V269, P540, DOI 10.1126/science.7624776
   Pfaffenbach KT, 2010, J NUTR, V140, P879, DOI 10.3945/jn.109.119883
   Preissler S, 2015, ELIFE, V4, DOI 10.7554/eLife.12621
   RESENDEZ E, 1988, MOL CELL BIOL, V8, P4579, DOI 10.1128/MCB.8.10.4579
   Rutkowski DT, 2006, PLOS BIOL, V4, P2024, DOI 10.1371/journal.pbio.0040374
   Rutkowski DT, 2008, DEV CELL, V15, P829, DOI 10.1016/j.devcel.2008.10.015
   Sano R, 2013, BBA-MOL CELL RES, V1833, P3460, DOI 10.1016/j.bbamcr.2013.06.028
   Shao ML, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4528
   Shen JS, 2002, DEV CELL, V3, P99, DOI 10.1016/S1534-5807(02)00203-4
   Shi YG, 1998, MOL CELL BIOL, V18, P7499, DOI 10.1128/MCB.18.12.7499
   So JS, 2012, CELL METAB, V16, P487, DOI 10.1016/j.cmet.2012.09.004
   Tyra HM, 2012, MOL BIOL CELL, V23, P811, DOI 10.1091/mbc.E11-12-1011
   Upton JP, 2012, SCIENCE, V338, P818, DOI 10.1126/science.1226191
   van Anken E, 2003, IMMUNITY, V18, P243, DOI 10.1016/S1074-7613(03)00024-4
   Walter P, 2011, SCIENCE, V334, P1081, DOI 10.1126/science.1209038
   Wang J, 2014, ELIFE, V3, DOI 10.7554/eLife.03496
   Wang YG, 2009, NATURE, V460, P534, DOI 10.1038/nature08111
   Wu J, 2007, DEV CELL, V13, P351, DOI 10.1016/j.devcel.2007.07.005
   Yamamoto K, 2004, J BIOCHEM, V136, P343, DOI 10.1093/jb/mvh122
   Yamamoto K, 2010, MOL BIOL CELL, V21, P2975, DOI 10.1091/mbc.E09-02-0133
   Yang L, 2015, SCIENCE, V349, P500, DOI 10.1126/science.aaa0079
   Ye J, 2000, MOL CELL, V6, P1355, DOI 10.1016/S1097-2765(00)00133-7
   Yoshida H, 2001, CELL, V107, P881, DOI 10.1016/S0092-8674(01)00611-0
   Yoshida H, 1998, J BIOL CHEM, V273, P33741, DOI 10.1074/jbc.273.50.33741
   Young CN, 2015, HYPERTENSION, V66, P920, DOI 10.1161/HYPERTENSIONAHA.115.03624
   Young CN, 2012, J CLIN INVEST, V122, P3960, DOI 10.1172/JCI64583
   Zhang KZ, 2011, EMBO J, V30, P1357, DOI 10.1038/emboj.2011.52
   Zhang KZ, 2006, CELL, V124, P587, DOI 10.1016/j.cell.2005.11.040
   Zhou AX, 2013, SEMIN IMMUNOPATHOL, V35, P321, DOI 10.1007/s00281-013-0372-x
   Zinszner H, 1998, GENE DEV, V12, P982, DOI 10.1101/gad.12.7.982
   Zode GS, 2011, J CLIN INVEST, V121, P3542, DOI 10.1172/JCI58183
NR 79
TC 30
Z9 38
U1 1
U2 15
PU ELIFE SCIENCES PUBLICATIONS LTD
PI CAMBRIDGE
PA SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND
SN 2050-084X
J9 ELIFE
JI eLife
PD DEC 10
PY 2016
VL 5
AR e20390
DI 10.7554/eLife.20390
PG 22
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA EH4MV
UT WOS:000391746200001
PM 27938665
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Ambrósio, G
   Kaufmann, FN
   Manosso, L
   Platt, N
   Ghisleni, G
   Rodrigues, ALS
   Rieger, DK
   Kaster, MP
AF Ambrosio, Gabriela
   Kaufmann, Fernanda N.
   Manosso, Luana
   Platt, Nicolle
   Ghisleni, Gabriele
   Rodrigues, Ana Lucia S.
   Rieger, Debora K.
   Kaster, Manuella P.
TI Depression and peripheral inflammatory profile of patients with obesity
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE Depression; Obesity; Body mass index; Inflammation
ID C-REACTIVE PROTEIN; PHYSICAL-ACTIVITY; METABOLIC SYNDROME;
   ADIPOSE-TISSUE; SYMPTOMS; WOMEN; ASSOCIATION; OVERWEIGHT; DISORDER;
   PEOPLE
AB This narrative review will present and discuss clinical data from 16 cross-sectional and 6 longitudinal studies examining the relationship between body mass index (BMI), symptoms of depression and peripheral inflammation. Our aim is to determine which of obesity and depression contributes best to the peripheral low-grade inflammation frequently associated to both conditions. Studies including a complete evaluation of inflammatory markers are scarce and high levels of interleukin-6 (IL-6) and C-reactive protein (CRP) are the most consistent findings associated with obesity and symptoms of depression. Among the cross-sectional studies, seven studies, including a total of 9421 individuals, pointed to BMI as the major factor associated with systemic low-grade inflammation. However, in four studies, including 16,837 individuals, CRP levels remained associated with the symptoms of depression even after correction for BMI, suggestion that in the absence of overweight or obesity other sources of peripheral inflammation might contribute to presence of depressive symptoms. Additionally, another five studies, including 5569 individuals failed to find an association between depression and peripheral inflammation, reinforcing the heterogeneity of this condition. In the longitudinal data, changes in BMI were associated with a reduction in depressive scores at follow-up, after bariatric surgery or after diet. In four longitudinal studies, high levels of CRP were found to be associated with depression even after adjustment for BMI and weight loss, further corroborating the idea that other sources of peripheral inflammation might contribute to depressive symptoms. Thus it seems that both obesity and depressive symptoms can contribute to peripheral inflammation, and once installed the presence of inflammation can contribute to several behavioral alterations that reinforce the cyclic pattern of co-occurrence observed in patients with obesity and MDD. Future clinical studies should focus on strategic efforts to collect new data and to improve or standardize methods for the evaluation of depression, body composition and a more complete inflammatory profile. These approaches are essential for the development of pharmacological and/or non-pharmacological strategies designed to break this cyclic pattern of co-occurrence.
C1 [Ambrosio, Gabriela; Kaufmann, Fernanda N.; Manosso, Luana; Platt, Nicolle; Rodrigues, Ana Lucia S.; Kaster, Manuella P.] Fed Univ Santa Catarina Florianopolis, Dept Biochem, Florianopolis, SC, Brazil.
   [Ghisleni, Gabriele] Univ Catolica Pelotas, Ctr Life & Hlth Sci, Pelotas, RS, Brazil.
   [Rieger, Debora K.] Univ Fed Santa Catarina, Dept Nutr, Florianopolis, SC, Brazil.
C3 Universidade Catolica de Pelotas; Universidade Federal de Pelotas;
   Universidade Federal de Santa Catarina (UFSC)
RP Kaster, MP (corresponding author), Fed Univ Santa Catarina Florianopolis, Dept Biochem, Florianopolis, SC, Brazil.
EM manuella.kaster@ufsc.br
RI Venske, Débora/K-6829-2016; Ghisleni, Gabriele/D-5032-2013; Kaster,
   Manuella/D-5028-2013; Rodrigues, Ana Lucia/P-6869-2015
OI Platt dos Santos, Nicolle/0000-0003-4794-9152; Kaster,
   Manuella/0000-0003-0258-6204; Kurrle Rieger Venske,
   Debora/0000-0002-8726-8899; Ghisleni, Gabriele/0000-0002-1764-6882;
   Rodrigues, Ana Lucia/0000-0001-6285-8780
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq);
   Coordenacao de Aperfeicoamento de Pessoal de Ensino Superior (CAPES)
FX All the authors declare no conflict of interests. This study was
   supported by Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq) and Coordenacao de Aperfeicoamento de Pessoal de
   Ensino Superior (CAPES). MPK and ALSR are CNPq Research Fellows.
CR [Anonymous], PSYCHONEUROENDOCRINO
   [Anonymous], COCHRANE DATABASE SY
   [Anonymous], BRAIN BEHAV IMMUN
   Benson S, 2008, BRAIN BEHAV IMMUN, V22, P177, DOI 10.1016/j.bbi.2007.07.003
   Byrne ML, 2015, CHILD PSYCHIAT HUM D, V46, P839, DOI 10.1007/s10578-014-0524-9
   Capuron L, 2011, PSYCHOL MED, V41, P1517, DOI 10.1017/S0033291710001984
   Capuron L, 2017, NEUROPSYCHOPHARMACOL, V42, P115, DOI 10.1038/npp.2016.123
   Carey M, 2014, BRIT J GEN PRACT, V64, pE122, DOI 10.3399/bjgp14X677482
   Carpenter KM, 2000, AM J PUBLIC HEALTH, V90, P251, DOI 10.2105/AJPH.90.2.251
   Carter MJ, 2014, THER RECREAT J, V48, P275
   Castanon N, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00074
   Daly M, 2013, OBESITY, V21, P248, DOI 10.1002/oby.20051
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   de Wit LM, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-14
   Demyttenaere K, 2003, PSYCHOTHER PSYCHOSOM, V72, P61, DOI 10.1159/000068690
   Dixon JB, 2008, OBESITY, V16, P2010, DOI 10.1038/oby.2008.271
   Dogan Y, 2011, CARDIOL RES PRACT, V2011, DOI 10.4061/2011/740957
   Emery CF, 2007, OBES SURG, V17, P759, DOI 10.1007/s11695-007-9140-0
   Evans-Lacko S, 2016, SOC PSYCH PSYCH EPID, V51, P1525, DOI 10.1007/s00127-016-1278-4
   Faith MS, 2011, OBES REV, V12, pe438, DOI 10.1111/j.1467-789X.2010.00843.x
   Fantuzzi G, 2005, J ALLERGY CLIN IMMUN, V115, P911, DOI 10.1016/j.jaci.2005.02.023
   Farioli-Vecchioli S, 2018, CURR NEUROPHARMACOL, V16, P308, DOI 10.2174/1570159X15666170912113852
   Fried SK, 1998, J CLIN ENDOCR METAB, V83, P847, DOI 10.1210/jc.83.3.847
   Goossens GH, 2017, OBESITY FACTS, V10, P207, DOI 10.1159/000471488
   HALLSTROM T, 1981, J PSYCHOSOM RES, V25, P75, DOI 10.1016/0022-3999(81)90093-3
   ISTVAN J, 1992, INT J OBESITY, V16, P999
   KITTEL F, 1978, J PSYCHOSOM RES, V22, P145, DOI 10.1016/0022-3999(78)90018-1
   Krishnan V, 2008, NATURE, V455, P894, DOI 10.1038/nature07455
   Ladwig KH, 2003, BRAIN BEHAV IMMUN, V17, P268, DOI 10.1016/S0889-1591(03)00056-4
   Liu YX, 2014, PSYCHIAT RES, V219, P103, DOI 10.1016/j.psychres.2014.05.025
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Mammen G, 2013, AM J PREV MED, V45, P649, DOI 10.1016/j.amepre.2013.08.001
   Markowitz S, 2008, CLIN PSYCHOL-SCI PR, V15, P1, DOI 10.1111/j.1468-2850.2008.00106.x
   Marmorstein NR, 2014, INT J OBESITY, V38, P906, DOI 10.1038/ijo.2014.19
   McEwen BS, 2013, NEURON, V79, P16, DOI 10.1016/j.neuron.2013.06.028
   Miller GE, 2002, AM J CARDIOL, V90, P1279, DOI 10.1016/S0002-9149(02)02863-1
   MOORE ME, 1962, JAMA-J AM MED ASSOC, V181, P962, DOI 10.1001/jama.1962.03050370030007
   Murabito JM, 2013, OBESITY, V21, P1713, DOI 10.1002/oby.20130
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Nicolau J, 2017, NUTR HOSP, V34, P81
   Olszanecka-Glinianowicz M, 2009, MEDIAT INFLAMM, V2009, DOI 10.1155/2009/439107
   Onyike CU, 2003, AM J EPIDEMIOL, V158, P1139, DOI 10.1093/aje/kwg275
   Pan A, 2012, INT J OBESITY, V36, P595, DOI 10.1038/ijo.2011.111
   Patten SB, 2018, EPIDEMIOL PSYCH SCI, V27, P42, DOI 10.1017/S204579601600072X
   Perez-Cornago A, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-36
   Qin TT, 2017, Sci Rep, P7
   Rethorst CD, 2014, J CLIN PSYCHIAT, V75, pE1428, DOI 10.4088/JCP.14m09009
   Rommel J, 2013, AM J CARDIOL, V111, P208, DOI 10.1016/j.amjcard.2012.09.017
   ROSS CE, 1994, J HEALTH SOC BEHAV, V35, P63, DOI 10.2307/2137335
   Schmidt FM, 2014, J PSYCHIATR RES, V55, P29, DOI 10.1016/j.jpsychires.2014.04.021
   Schuch F, 2017, J AFFECT DISORDERS, V210, P139, DOI 10.1016/j.jad.2016.10.050
   Shelton RC, 2015, J PSYCHIATR RES, V70, P91, DOI 10.1016/j.jpsychires.2015.09.001
   SHERBOURNE CD, 1994, AM J PSYCHIAT, V151, P1777
   Simon GE, 2008, GEN HOSP PSYCHIAT, V30, P32, DOI 10.1016/j.genhosppsych.2007.09.001
   Singh M, 2014, FRONT PSYCHOL, V5, DOI 10.3389/fpsyg.2014.00925
   Topic R, 2013, CROAT MED J, V54, P453, DOI 10.3325/cmj.2013.54.453
   Toups MSP, 2011, J PSYCHIATR RES, V45, P1301, DOI 10.1016/j.jpsychires.2011.05.002
   Valentine RJ, 2011, BRAIN BEHAV IMMUN, V25, P1482, DOI 10.1016/j.bbi.2011.06.002
   Vancampfort D, 2015, PSYCHIAT DANUB, V27, P210
   Viscogliosi G, 2013, INT J GERIATR PSYCH, V28, P242, DOI 10.1002/gps.3817
   Vos T, 2015, LANCET, V386, P743, DOI 10.1016/S0140-6736(15)60692-4
   WHO, 2014, GLOBAL STATUS REPORT ON VIOLENCE PREVENTION 2014, P1
NR 62
TC 78
Z9 85
U1 2
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAY
PY 2018
VL 91
BP 132
EP 141
DI 10.1016/j.psyneuen.2018.03.005
PG 10
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA GK5KT
UT WOS:000436214700017
PM 29550676
DA 2025-06-11
ER

PT J
AU Babtan, AM
   Vesa, SC
   Bosca, BA
   Crisan, M
   Mihu, CM
   Baciut, MF
   Dinu, C
   Crisan, B
   Campian, RS
   Feurdean, CN
   Ionel, A
   Bezugly, A
   Bordea, IR
   Ilea, A
AF Babtan, Anida Maria
   Vesa, Stefan Cristian
   Bosca, Bianca Adina
   Crisan, Maria
   Mihu, Carmen Mihaela
   Baciut, Mihaela Felicia
   Dinu, Cristian
   Crisan, Bogdan
   Campian, Radu Septimiu
   Feurdean, Claudia Nicoleta
   Ionel, Anca
   Bezugly, Artur
   Bordea, Ioana Roxana
   Ilea, Aranka
TI High-Frequency Ultrasound Assessment of Skin and Oral Mucosa in
   Metabolic Syndrome Patients-A Cross-Sectional Study
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE high-frequency ultrasound; oral mucosa; skin; metabolic syndrome;
   inflammation; aging
ID ADIPOSE-TISSUE DENSITY; OXIDATIVE STRESS; AGE; COLLAGEN; DEPTH
AB Background: Exogenous factors (such as sun exposure, smoking habits, and diet) and endogenous (inflammatory status, general diseases) have a direct influence on skin and soft tissue characteristics. The study's objective was to assess the impact of metabolic syndrome (MS) on characteristics of skin layers in sun-exposed and non-exposed maxillofacial tissues evaluated by high-frequency ultrasound (HFU), as a potential diagnosis and monitoring tool for the aging process. Material and methods: The present study included 102 subjects (24 with MS; 78 without MS). Anthropometric parameters and disease history were recorded, and blood samples were harvested in order to assess biochemical parameters of MS. Sun-exposed skin (zygomatic region) and non-exposed oral mucosa of the lower lip were assessed using HFU (DUB(R) cutis, Taberna Pro Medicum) with a 22 MHz probe. Results: Patients with cardiac disease had significantly lower values for epidermis density (p = 0.002). Gender was independently linked to the aged dermis depth (p < 0.001), aged dermis no. of px (pixels) (p < 0.001), dermis depth (p < 0.001), dermis no. of px (p < 0.001), and subcutaneous tissue density (p < 0.001). Patients with MS had thinner epidermis (p = 0.008) and thinner aged dermis (p = 0.037) when compared to non-MS subjects. Conclusion: Patients with MS had thinner epidermis and a lower epidermis number of pixels in sun-exposed skin. Women had lower epidermis density and thicker dermis in sun-exposed skin. Our study showed that HFU, as a non-invasive investigation approach, is useful to diagnose and monitor the aging process in skin and oral mucosa, correlated with skin phenotype pathological conditions.
C1 [Babtan, Anida Maria; Campian, Radu Septimiu; Feurdean, Claudia Nicoleta; Ionel, Anca; Ilea, Aranka] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Fac Dent, Oral Rehabil Dept, Babes St 15, Cluj Napoca 400012, Cluj County, Romania.
   [Vesa, Stefan Cristian] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Fac Med, Pharmacol Toxicol & Clin Pharmacol Dept, Marinescu St 23, Cluj Napoca 400337, Cluj County, Romania.
   [Bosca, Bianca Adina; Crisan, Maria; Mihu, Carmen Mihaela] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Fac Med, Histol Dept, Pasteur St 4, Cluj Napoca 400349, Cluj County, Romania.
   [Baciut, Mihaela Felicia; Dinu, Cristian; Crisan, Bogdan] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Fac Dent, Maxillofacial Surg & Implantol Dept, Cardinal Iuliu Hossu St 37, Cluj Napoca 400349, Cluj County, Romania.
   [Bezugly, Artur] Russian Fed Med Biol Agcy, Acad Postgrad Educ, Dermatol & Cosmetol Dept, Moscow 123098, Russia.
   [Bordea, Ioana Roxana] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Fac Dent, Oral Hlth Dept, Babes St 15, Cluj Napoca 400012, Cluj County, Romania.
C3 Iuliu Hatieganu University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy; Iuliu Hatieganu University of
   Medicine & Pharmacy; Iuliu Hatieganu University of Medicine & Pharmacy;
   Iuliu Hatieganu University of Medicine & Pharmacy
RP Vesa, SC (corresponding author), Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Fac Med, Pharmacol Toxicol & Clin Pharmacol Dept, Marinescu St 23, Cluj Napoca 400337, Cluj County, Romania.
EM anidamaria.babtan@gmail.com; stefanvesa@gmail.com;
   biancabosca@yahoo.com; mcrisan7@yahoo.com; carmenmihu2004@yahoo.com;
   mbaciut@umfcluj.ro; dinu_christian@yahoo.com; crisan.bogdan@umfcluj.ro;
   rcampian@ymail.com; cbraitoru@yahoo.com; anca_ionel@yahoo.com;
   drarturbezugly@gmail.com; roxana.bordea@ymail.com; arankailea@yahoo.com
RI Ilea, Aranka/N-6040-2014; Bezugly, Artur/HHS-0841-2022; Vesa,
   Stefan/I-2481-2019; mihu, carmen/C-2936-2012; Crisan,
   Maria/AAA-4298-2019; Nicoleta, Feurdean/AAO-8526-2021; Boșca,
   Bianca/AAS-7779-2021; Ionel, Anca/LZF-5765-2025; Dinu,
   Cristian/AAB-4732-2022; Bordea, Ioana Roxana/AAK-7454-2020; Baciut,
   Mihaela/AET-0157-2022
OI Vesa, Stefan Cristian/0000-0003-4549-3526; Bordea, Ioana
   Roxana/0000-0001-7166-9949; Babtan, Anida-Maria/0000-0003-0070-4991;
   Baciut, Mihaela/0000-0003-3495-2758; Bosca, Adina
   Bianca/0000-0002-3835-2090; Ilea, Aranka/0000-0002-1033-0906
CR Akase T, 2012, BIOL RES NURS, V14, P180, DOI 10.1177/1099800411401013
   Baban A, 2017, HVM BIOFLUX, V11, P106
   Barsh GS, 2003, PLOS BIOL, V1, P19, DOI 10.1371/journal.pbio.0000027
   Bridal SL, 2006, ULTRASONIC IMAGING, V28, P23, DOI 10.1177/016173460602800103
   Chifor Radu, 2019, Med Pharm Rep, V92, pS20, DOI 10.15386/mpr-1521
   Crisan D, 2015, CLIN COSMET INVESTI, V8, P463, DOI 10.2147/CCID.S84903
   Crisan D, 2012, CLIN COSMET INV DERM, V5, P7, DOI 10.2147/CCID.S25840
   Crisan M, 2013, ARCH DERMATOL RES, V305, P305, DOI 10.1007/s00403-013-1321-1
   Crisan M, 2012, COMPUT MATH METHOD M, V2012, DOI 10.1155/2012/103919
   Del Bino S, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19092668
   Evirgen S, 2016, WORLD J RADIOL, V8, P50, DOI 10.4329/wjr.v8.i1.50
   Firooz A, 2017, SKIN RES TECHNOL, V23, P13, DOI 10.1111/srt.12294
   Gill V, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9120888
   Hertzberg O, 2017, ANALYST, V142, P495, DOI 10.1039/c6an02278b
   Hjerrild JN, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061409
   Huzaira M, 2001, J INVEST DERMATOL, V116, P846, DOI 10.1046/j.0022-202x.2001.01337.x
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Khlebnikova AN, 2018, MED ULTRASON, V20, P475, DOI 10.11152/mu-1633
   Kim MS, 2020, SKIN RES TECHNOL, V26, P769, DOI 10.1111/srt.12858
   Li Xiaoyan, 2015, Zhonghua Yi Xue Za Zhi, V95, P52
   MARTIN AD, 1994, INT J OBESITY, V18, P79
   Matsumoto M, 2014, INT J COSMETIC SCI, V36, P477, DOI 10.1111/ics.12145
   Moldovan Mirela, 2017, Clujul Med, V90, P212, DOI 10.15386/cjmed-668
   Moore JV, 2003, BRIT J DERMATOL, V149, P1035, DOI 10.1111/j.1365-2133.2003.05558.x
   Murphy RA, 2014, J GERONTOL A-BIOL, V69, P109, DOI 10.1093/gerona/glt070
   Olesen CM, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-48698-w
   Parikh Rakesh M, 2012, Indian J Endocrinol Metab, V16, P7, DOI 10.4103/2230-8210.91175
   Rinnerthaler M, 2015, BIOMOLECULES, V5, P545, DOI 10.3390/biom5020545
   Ruiz-Esparza GU, 2013, INT J NANOMED, V8, P629, DOI 10.2147/IJN.S30599
   Sadowska-Bartosz I, 2016, MECH AGEING DEV, V160, P1, DOI 10.1016/j.mad.2016.09.006
   Sandby-Moller J, 2004, SKIN RES TECHNOL, V10, P57, DOI 10.1111/j.1600-0846.2004.00056.x
   Selkow NM, 2011, J ATHL TRAINING, V46, P50, DOI 10.4085/1062-6050-46.1.50
   Störchle P, 2017, ULTRASOUND MED BIOL, V43, P427, DOI 10.1016/j.ultrasmedbio.2016.09.014
   Vashi Neelam A, 2016, J Clin Aesthet Dermatol, V9, P31
   Vergilio MM, 2021, SKIN RES TECHNOL, V27, P966, DOI 10.1111/srt.13033
   Wortsman X, 2010, J AM ACAD DERMATOL, V62, P247, DOI 10.1016/j.jaad.2009.06.016
NR 36
TC 1
Z9 1
U1 4
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD OCT
PY 2021
VL 10
IS 19
AR 4461
DI 10.3390/jcm10194461
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA WK2BB
UT WOS:000709535200001
PM 34640479
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Beydoun, MA
   Chen, XL
   Jha, K
   Beydoun, HA
   Zonderman, AB
   Canas, JA
AF Beydoun, May A.
   Chen, Xiaoli
   Jha, Kanishk
   Beydoun, Hind A.
   Zonderman, Alan B.
   Canas, Jose A.
TI Carotenoids, vitamin A, and their association with the metabolic
   syndrome: a systematic review and meta-analysis
SO NUTRITION REVIEWS
LA English
DT Review
DE carotenoids; meta-analysis; metabolic syndrome; vitamin A
ID 3RD NATIONAL-HEALTH; SERUM ANTIOXIDANT CONCENTRATIONS; ARTERY RISK
   DEVELOPMENT; DIABETES-MELLITUS; BETA-CAROTENE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; LOWER PREVALENCE; CARDIOVASCULAR-DISEASE;
   ALPHA-TOCOPHEROL
AB Context: Modifiable factors that reduce the burden of the metabolic syndrome (MetS), particularly plant-derived biomarkers, have been a recent focus of rising interest. Objective: This systematic review and meta-analysis, which follows PRISMA guidelines, evaluates evidence from a period of 20 years that links vitamin A and carotenoids with the occurrence of MetS and following the PRISMA guidelines. Data Sources: PubMed and Cochrane databases (January 1997 through March 2017) were systematically assessed for studies, including case-control, cross-sectional, and cohort studies, that evaluated the associations of MetS with carotenoids and retinyl esters and retinol (vitamin A). Data Extraction: Key measures of associations were harmonized into odds ratios (ORs) and 95% confidence intervals (95% CI) of MetS per 1 standard deviation (SD) of exposure using forest plots and random effects models that pooled data points from 11 cross-sectional studies. Begg's funnel and harvest plots were constructed. Results: An inverse association between total carotenoids and MetS was found [ORpooled, 0.66; 95% CI, 0.56-0.78; 1 SD similar to 0.82 mu mol/L; n = 5 studies]. This association was the strongest for beta-carotene, followed by alpha-carotene and beta-crypotoxanthin. No association was detected between retinol and MetS (ORpooled, 1.00; 95% CI, 0.88-1.13; 1 SD similar to 2.14 mu mmol/L; n = 6 studies). Publication bias was absent, and harvest plots indicated consistency upon replication for beta-carotene and total carotenoid exposures. Conclusions: This review and meta-analysis suggests that, unlike retinol, total and individual carotenoids were inversely related to MetS.
C1 [Beydoun, May A.; Zonderman, Alan B.] NIA, Lab Epidemiol & Populat Sci, NIH, Intramural Res Program, Baltimore, MD 21224 USA.
   [Chen, Xiaoli] Massachusetts Dept Publ Hlth, Bur Family Hlth & Nutr, Boston, MA USA.
   [Jha, Kanishk] Nemours Childrens Clin, Jacksonville, FL USA.
   [Beydoun, Hind A.] Johns Hopkins Med Inst, Dept Med, Baltimore, MD 21205 USA.
   [Canas, Jose A.] Johns Hopkins All Childrens Hosp, St Petersburg, FL USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); Massachusetts Department of Public Health; Johns Hopkins
   University; Johns Hopkins Medicine; Johns Hopkins University; Johns
   Hopkins Medicine
RP Beydoun, MA (corresponding author), NIA, NIH, Biomed Res Ctr, IRP, 251 Bayview Blvd,Suite 100,Room 04B118, Baltimore, MD 21224 USA.
EM baydounm@mail.nih.gov
RI Zonderman, Alan/A-5807-2013; Canas, Jose/Y-8500-2019; Canas,
   Jose/F-3193-2017
OI Canas, Jose/0000-0003-4788-8820
FU Intramural Research Program of the National Institutes of Health,
   National Institute on Aging
FX This research was supported entirely by the Intramural Research Program
   of the National Institutes of Health, National Institute on Aging.
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Ali Rohaid, 2013, Int J Health Nutr, V4, P33
   Amini M, 2010, NUTRITION, V26, P986, DOI 10.1016/j.nut.2010.03.006
   Appels CWY, 2006, NEW ENGL J MED, V355, P2699
   Appels CW, N ENGL J MED, P2700
   BEGG CB, 1994, BIOMETRICS, V50, P1088, DOI 10.2307/2533446
   Bender R, 2006, J CLIN EPIDEMIOL, V59, P1064, DOI 10.1016/j.jclinepi.2006.01.006
   Beydoun MA, 2012, J NUTR, V142, P1693, DOI 10.3945/jn.112.160416
   Beydoun MA, 2011, J NUTR, V141, P903, DOI 10.3945/jn.110.136580
   Bohn T, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600685
   Borenstein M, 2021, Introduction to Meta-Analysis
   CAMPBELL DR, 1994, CANCER EPIDEM BIOMAR, V3, P493
   Canas JA, 2017, J CLIN ENDOCR METAB, V102, P1983, DOI 10.1210/jc.2017-00185
   Canas JA, 2015, J NUTR SCI, V4, DOI 10.1017/jns.2015.29
   Canas JA, 2012, J PEDIATR-US, V161, P58, DOI 10.1016/j.jpeds.2012.01.030
   Carter Patrice, 2010, BMJ, V341, pc4229, DOI 10.1136/bmj.c4229
   Chen CC, 2009, METABOLISM, V58, P1812, DOI 10.1016/j.metabol.2009.06.013
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Colditz GA, 1999, MED SCI SPORT EXER, V31, pS663, DOI 10.1097/00005768-199911001-00026
   Coyne T, 2005, AM J CLIN NUTR, V82, P685, DOI 10.1093/ajcn/82.3.685
   Coyne T, 2009, BRIT J NUTR, V102, P1668, DOI 10.1017/S000711450999081X
   Crowther M, 2011, RES SYNTH METHODS, V2, P79, DOI 10.1002/jrsm.37
   Czernichow S, 2009, AM J CLIN NUTR, V90, P329, DOI 10.3945/ajcn.2009.27635
   Dakshinamurti K, 2015, CAN J PHYSIOL PHARM, V93, P355, DOI 10.1139/cjpp-2014-0479
   de Toro-Martín J, 2017, NUTRIENTS, V9, DOI 10.3390/nu9080913
   Doig GS, 2004, CRIT CARE MED, V32, P1084, DOI 10.1097/01.CCM.0000119934.01548.AF
   During A, 2007, J LIPID RES, V48, P2283, DOI 10.1194/jlr.M700263-JLR200
   Egger M, 1997, BMJ-BRIT MED J, V315, P629, DOI 10.1136/bmj.315.7109.629
   Egger M, 2001, SYSTEMATIC REV HEATL
   Ferrucci L, 2007, ARCH INTERN MED, V167, P750, DOI 10.1001/archinte.167.8.750
   Ford ES, 1999, AM J EPIDEMIOL, V149, P168, DOI 10.1093/oxfordjournals.aje.a009783
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Godala M, 2016, MENOPAUSE REV, V15, P32, DOI 10.5114/pm.2016.58771
   Godala MM, 2016, ADV CLIN EXP MED, V25, P689, DOI 10.17219/acem/41049
   Grundy SM, 1999, AM J CARDIOL, V83, p25F
   Grune T, 2010, J NUTR, V140, p2268S, DOI 10.3945/jn.109.119024
   Han GM, 2016, BRIT J NUTR, V115, P1292, DOI 10.1017/S0007114516000179
   Hill JO, 2004, AM J PREV MED, V27, P111, DOI 10.1016/j.amepre.2004.06.010
   Hozawa A, 2006, AM J EPIDEMIOL, V163, P929, DOI 10.1093/aje/kwj136
   Kataja-Tuomola M, 2008, DIABETOLOGIA, V51, P47, DOI 10.1007/s00125-007-0864-0
   Khillan JS, 2014, NUTRIENTS, V6, P1209, DOI 10.3390/nu6031209
   Leermakers ETM, 2016, AM J CLIN NUTR, V103, P481, DOI 10.3945/ajcn.115.120931
   Li YR, 2013, ASIA PAC J CLIN NUTR, V22, P60, DOI 10.6133/apjcn.2013.22.1.06
   Lim Hee-Sook, 2017, Clin Nutr Res, V6, P38, DOI 10.7762/cnr.2017.6.1.38
   Liu J, 2014, BRIT J NUTR, V112, P2041, DOI 10.1017/S000711451400316X
   Liu SM, 1999, JAMA-J AM MED ASSOC, V282, P1073, DOI 10.1001/jama.282.11.1073
   Bonet ML, 2016, SUBCELL BIOCHEM, V79, P377, DOI 10.1007/978-3-319-39126-7_15
   Bonet ML, 2015, ARCH BIOCHEM BIOPHYS, V572, P112, DOI 10.1016/j.abb.2015.02.022
   Molnár D, 2004, INT J OBESITY, V28, P1197, DOI 10.1038/sj.ijo.0802719
   Montonen J, 2004, DIABETES CARE, V27, P362, DOI 10.2337/diacare.27.2.362
   O'Neil CE, 2012, NUTR J, V11, DOI 10.1186/1475-2891-11-107
   Ogilvie D, 2008, BMC MED RES METHODOL, V8, DOI 10.1186/1471-2288-8-8
   Palmieri VO, 2006, J NUTR, V136, P3022, DOI 10.1093/jn/136.12.3022
   Park K, 2009, DIABETES CARE, V32, P1302, DOI 10.2337/dc09-0259
   Park S, 2015, NUTRITION, V31, P111, DOI 10.1016/j.nut.2014.05.011
   Petitti DB., 2000, META ANAL DECISION A, V2nd, P94
   Rao AV, 2007, PHARMACOL RES, V55, P207, DOI 10.1016/j.phrs.2007.01.012
   Reunanen A, 1998, EUR J CLIN NUTR, V52, P89, DOI 10.1038/sj.ejcn.1600519
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Schreiber R, 2012, BBA-MOL CELL BIOL L, V1821, P113, DOI 10.1016/j.bbalip.2011.05.001
   Sesso HD, 2006, CURR OPIN LIPIDOL, V17, P11, DOI 10.1097/01.mol.0000203888.42514.27
   Sharma P, 2005, INDIAN J CLIN BIOCHE, V20, P145, DOI 10.1007/BF02893061
   Sluijs I, 2009, J NUTR, V139, P987, DOI 10.3945/jn.108.101451
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Solomon CG, 1997, AM J CLIN NUTR, V66, P1044, DOI 10.1093/ajcn/66.4.1044S
   Soory Mena, 2009, Infectious Disorders - Drug Targets, V9, P400
   Stata Corporation, 2015, STAT DAT AN REL 14 0
   Stevens J, 2000, NUTR REV, V58, P346, DOI 10.1111/j.1753-4887.2000.tb01832.x
   STRYKER WS, 1988, AM J EPIDEMIOL, V127, P283, DOI 10.1093/oxfordjournals.aje.a114804
   Sugiura M, 2008, BRIT J NUTR, V100, P1297, DOI 10.1017/S0007114508978302
   Sugiura M, 2015, BRIT J NUTR, V114, P1674, DOI 10.1017/S0007114515003268
   Suriyaprom K, 2014, INT J VITAM NUTR RES, V84, P35, DOI 10.1024/0300-9831/a000191
   Suzuki K, 2011, CLIN NUTR, V30, P369, DOI 10.1016/j.clnu.2010.12.006
   Valtueña S, 2007, EUR J CLIN NUTR, V61, P69, DOI 10.1038/sj.ejcn.1602485
   Voutilainen S, 2006, AM J CLIN NUTR, V83, P1265
   Wang L, 2006, J NUTR, V136, P620, DOI 10.1093/jn/136.3.620
   Wang L, 2006, AM J EPIDEMIOL, V164, P576, DOI 10.1093/aje/kwj240
   Wei J, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0130876
   Wolf AM, 1998, OBES RES, V6, P97, DOI 10.1002/j.1550-8528.1998.tb00322.x
   Zimmermann MB, 2008, INT J OBESITY, V32, pS11, DOI 10.1038/ijo.2008.202
NR 83
TC 109
Z9 110
U1 0
U2 35
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD JAN
PY 2019
VL 77
IS 1
BP 32
EP 45
DI 10.1093/nutrit/nuy044
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HH8ZS
UT WOS:000456023400003
PM 30202882
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Gruppen, EG
   Connelly, MA
   Otvos, JD
   Bakker, SJL
   Dullaart, RPF
AF Gruppen, Eke G.
   Connelly, Margery A.
   Otvos, James D.
   Bakker, Stephan J. L.
   Dullaart, Robin P. F.
TI A novel protein glycan biomarker and LCAT activity in metabolic syndrome
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE Diabetes mellitus; glycoproteins; high-sensitivity C-reactive;
   lecithin:cholesterol acyltransferase; metabolic syndrome
ID LECITHIN-CHOLESTEROL ACYLTRANSFERASE; HIGH-DENSITY-LIPOPROTEIN; PLASMA
   LECITHIN; ANTIOXIDATIVE FUNCTIONALITY; THERAPEUTIC TARGET;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; OXIDIZED LIPIDS; SERUM;
   GLYCOSYLATION
AB BackgroundThe cholesterol-esterifying enzyme, lecithin:cholesterol acyltransferase (LCAT), is instrumental in high-density lipoprotein (HDL) remodelling. LCAT may also modify oxidative and inflammatory processes, as supported by an inverse relationship with HDL antioxidative functionality and a positive relationship with high-sensitivity C-reactive protein (hsCRP). GlycA is a recently developed proton nuclear magnetic resonance (NMR) spectroscopy-measured biomarker of inflammation whose signal originates from a subset of N-acetylglucosamine residues on the most abundant glycosylated acute-phase proteins. Plasma GlycA correlates positively with hsCRP and may predict cardiovascular disease even independent of hsCRP. Here, we tested the extent to which plasma GlycA is elevated in metabolic syndrome (MetS), and determined its relationship with LCAT activity.
   Materials and methodsPlasma GlycA, hsCRP, serum amyloid A (SAA), tumour necrosis factor- (TNF-) and LCAT activity were measured in 58 subjects with MetS (including 46 subjects with type 2 diabetes mellitus (T2DM)) and in 45 nondiabetic subjects without MetS.
   ResultsPlasma GlycA was higher in MetS coinciding with higher hsCRP and LCAT activity (P<001 for each). In all subjects combined, GlycA was correlated positively with hsCRP, SAA and LCAT activity (P<0001 for each), but not with TNF-. Age- and sex-adjusted multivariable linear regression analysis revealed that GlycA was positively associated with LCAT activity (P=0029), independent of the presence of MetS, T2DM, hsCRP and SAA. GlycA was unrelated to diabetes status.
   ConclusionA pro-inflammatory glycoprotein biomarker, GlycA, is higher in MetS. Higher plasma levels of this glycoprotein biomarker relate to increased LCAT activity in the setting of MetS.
C1 [Gruppen, Eke G.; Dullaart, Robin P. F.] Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, Groningen, Netherlands.
   [Gruppen, Eke G.; Bakker, Stephan J. L.] Univ Groningen, Univ Med Ctr Groningen, Dept Nephrol, Groningen, Netherlands.
   [Connelly, Margery A.; Otvos, James D.] LabCorp, Raleigh, NC 27616 USA.
C3 University of Groningen; University of Groningen
RP Dullaart, RPF (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, POB 30-001, NL-9700 RB Groningen, Netherlands.
EM r.p.f.dullaart@int.umcg.nl
RI Connelly, Margery/IZP-5440-2023; Bakker, Stephan/J-4023-2015
OI Bakker, Stephan/0000-0003-3356-6791
CR Akinkuolie AO, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.114.001221
   ALBERS JJ, 1981, J LIPID RES, V22, P1206
   Arnold JN, 2008, PROTEOMICS, V8, P3284, DOI 10.1002/pmic.200800163
   BELL JD, 1987, FEBS LETT, V215, P311, DOI 10.1016/0014-5793(87)80168-0
   Calabresi L, 2012, ATHEROSCLEROSIS, V222, P299, DOI 10.1016/j.atherosclerosis.2011.11.034
   Calabresi L, 2011, J LIPID RES, V52, P1569, DOI 10.1194/jlr.P014977
   Collins ES, 2013, RHEUMATOLOGY, V52, P1572, DOI 10.1093/rheumatology/ket189
   de Vries Rindert, 2003, Clin Lab, V49, P601
   Degoma EM, 2008, J AM COLL CARDIOL, V51, P2199, DOI 10.1016/j.jacc.2008.03.016
   Dullaart RPF, 2010, BBA-MOL CELL BIOL L, V1801, P84, DOI 10.1016/j.bbalip.2009.09.019
   Dullaart RPF, 2014, ATHEROSCLEROSIS, V234, P185, DOI 10.1016/j.atherosclerosis.2014.02.026
   Dullaart RPF, 2013, OBESITY, V21, P361, DOI 10.1002/oby.20058
   Dullaart RPF, 2010, ATHEROSCLEROSIS, V208, P537, DOI 10.1016/j.atherosclerosis.2009.07.042
   Dullaart RPF, 2008, J CLIN ENDOCR METAB, V93, P4860, DOI 10.1210/jc.2008-1213
   DULLAART RPF, 1994, EUR J CLIN INVEST, V24, P188, DOI 10.1111/j.1365-2362.1994.tb00987.x
   FLOREN CH, 1987, SCAND J CLIN LAB INV, V47, P613
   GLOMSET JA, 1968, J LIPID RES, V9, P155
   Gornik O, 2008, DIS MARKERS, V25, P267, DOI 10.1155/2008/493289
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Haase CL, 2012, J CLIN ENDOCR METAB, V97, pE248, DOI 10.1210/jc.2011-1846
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Hazenberg BPC, 1999, ANN RHEUM DIS, V58, P96, DOI 10.1136/ard.58.2.96
   Holleboom AG, 2010, J LIPID RES, V51, P416, DOI 10.1194/P900038-JLR200
   Hovingh GK, 2005, CIRCULATION, V112, P879, DOI 10.1161/CIRCULATIONAHA.105.540427
   Jacobs M, 2009, EUR J CLIN INVEST, V39, P437, DOI 10.1111/j.1365-2362.2009.02129.x
   James RW, 2004, FREE RADICAL BIO MED, V37, P1986, DOI 10.1016/j.freeradbiomed.2004.08.012
   Jeyarajah EJ, 2006, CLIN LAB MED, V26, P847, DOI 10.1016/j.cll.2006.07.006
   Kappelle PJWH, 2012, EUR J CLIN INVEST, V42, P487, DOI 10.1111/j.1365-2362.2011.02604.x
   Kappelle PJWH, 2011, ARCH MED RES, V42, P219, DOI 10.1016/j.arcmed.2011.05.002
   Kontush A, 2006, PHARMACOL REV, V58, P342, DOI 10.1124/pr.58.3.1
   Kumon Y, 1998, SCAND J IMMUNOL, V48, P419
   Kunnen S, 2012, J LIPID RES, V53, P1783, DOI 10.1194/jlr.R024513
   Loued S, 2012, LIFE SCI, V90, P82, DOI 10.1016/j.lfs.2011.10.018
   Mariño K, 2010, NAT CHEM BIOL, V6, P713, DOI [10.1038/nchembio.437, 10.1038/NCHEMBIO.437]
   Maury E, 2010, MOL CELL ENDOCRINOL, V314, P1, DOI 10.1016/j.mce.2009.07.031
   McPherson PAC, 2007, FREE RADICAL BIO MED, V43, P1484, DOI 10.1016/j.freeradbiomed.2007.08.007
   McPherson PAC, 2007, J LIPID RES, V48, P86, DOI 10.1194/jlr.M600094-JLR200
   Muhlestein JB, 2014, J AM COLL CARDIOL, V63
   Navab M, 2009, DIABETES, V58, P2711, DOI 10.2337/db09-0538
   Ng DS, 2002, J BIOL CHEM, V277, P11715, DOI 10.1074/jbc.M112320200
   Nilsson J, 1998, ARTERIOSCL THROM VAS, V18, P1199, DOI 10.1161/01.ATV.18.8.1199
   Ohtsubo K, 2006, CELL, V126, P855, DOI 10.1016/j.cell.2006.08.019
   Otvos JD, 2015, CLIN CHEM, V61, P714, DOI 10.1373/clinchem.2014.232918
   Pearson TA, 2003, CIRCULATION, V107, P499, DOI 10.1161/01.CIR.0000052939.59093.45
   Rousset X, 2011, CURR ATHEROSCLER REP, V13, P249, DOI 10.1007/s11883-011-0171-6
   Rutten G.E., 2006, HUISARTS WET, V49, P137
   Selvin S., 2004, STAT ANAL EPIDEMIOLO
   Simera I, 2010, EUR J CLIN INVEST, V40, P35, DOI 10.1111/j.1365-2362.2009.02234.x
   Spahr C, 2013, PROTEIN SCI, V22, P1739, DOI 10.1002/pro.2373
   Tanaka S, 2013, ARTERIOSCL THROM VAS, V33, P1098, DOI 10.1161/ATVBAHA.113.301297
   Triolo M, 2013, BIOMARK MED, V7, P457, DOI [10.2217/BMM.13.35, 10.2217/bmm.13.35]
   Vohl MC, 1999, BIOCHEMISTRY-US, V38, P5976, DOI 10.1021/bi982258w
   Windgassen EB, 2011, POSTGRAD MED, V123, P114, DOI 10.3810/pgm.2011.01.2252
   Wurtz P, 2012, DIABETES CARE, V35, P1749, DOI 10.2337/dc11-1838
   Würtz P, 2012, DIABETES, V61, P1372, DOI 10.2337/db11-1355
NR 55
TC 29
Z9 30
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD AUG
PY 2015
VL 45
IS 8
BP 850
EP 859
DI 10.1111/eci.12481
PG 10
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA CN3ZP
UT WOS:000358367700010
PM 26081900
DA 2025-06-11
ER

PT J
AU Seres, I
   Fóris, G
   Varga, Z
   Kosztáczky, B
   Kassai, A
   Balogh, Z
   Fülöp, P
   Paragh, G
AF Seres, Ildiko
   Foris, Gabriella
   Varga, Zsuzsa
   Kosztaczky, Bela
   Kassai, Andrea
   Balogh, Zoltan
   Fueloep, Peter
   Paragh, Gyoergy
TI The association between angiotensin II-induced free radical generation
   and membrane fluidity in neutrophils of patients with metabolic syndrome
SO JOURNAL OF MEMBRANE BIOLOGY
LA English
DT Article
DE angiotensin II; free radical; membrane fluidity; neutrophil; metabolic
   syndrome
ID STEAROYL-COA DESATURASE; POLYUNSATURATED FATTY-ACIDS; ALTERED SIGNAL
   PATHWAY; NADPH OXIDASE; PHOSPHOLIPASE A(2); OXIDATIVE STRESS;
   RESPIRATORY BURST; PROTEIN-KINASE; BLOOD-CELLS; EXTRACTION
AB Angiotensin II (Ang II) is able to induce free radical generation in neutrophils, which is more elevated in neutrophils of patients with hypercholesterolemia (HC). In addition, the signal processing through angiotensin I (Ang I) receptors is altered. In present study, we compared the Ang II-triggered free radical generation of neutrophils obtained from patients with relatively isolated forms of metabolic syndrome (MS) with membrane-bound cholesterol content and membrane fluidity. We determined the enhancement of Ang II-induced superoxide anion and leukotriene C-4 (LTC4) generation, membrane fluidity and cell-bound cholesterol content of neutrophils obtained from 12 control subjects, 11 patients with obesity (Ob), 10 patients with type 2 diabetes mellitus (t2-DM) and 12 patients with HC. The alteration of signal processing was studied after preincubation with different inhibiting drugs. Superoxide anion, LTC4 production and membrane rigidity were increased in the following order: control < Ob < t2-DM < HC. Both Ang II-induced superoxide anion and LTC4 generation were decreased in control cells by pertussis toxin and fluvastatin (Flu), whereas in each patient group, mepacrin, verapamil and Flu were effective, suggesting alterations in signal pathways, which may be attributed to isoprenylation. The enhancement of superoxide anion and LTC4 generation correlated signifficantly with membrane rigidity, independently from the experimental groups and membrane-bound cholesterol content. Membrane rigidity of neutrophils, obtained from patients with MS, plays a role in Ang II-induced free radical generation independent of intracellular cholesterol homeostasis.
C1 Univ Debrecen, Dept Med 1, Med & Hlth Sci Ctr, H-4012 Debrecen, Hungary.
C3 University of Debrecen
RP Fóris, G (corresponding author), Univ Debrecen, Dept Med 1, Med & Hlth Sci Ctr, Nagyerdei Krt 98, H-4012 Debrecen, Hungary.
EM forisg@jaguar.unideb.hu
CR Alvarez E, 2001, CLIN EXP IMMUNOL, V124, P95, DOI 10.1046/j.1365-2249.2001.01490.x
   BALLA G, 1991, ARTERIOSCLER THROMB, V11, P1700, DOI 10.1161/01.ATV.11.6.1700
   Bell R M, 1986, Methods Enzymol, V124, P353
   Berk BC, 1997, CIRC RES, V80, P607, DOI 10.1161/01.RES.80.5.607
   BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911
   Bokoch GM, 2002, BLOOD, V100, P2692, DOI 10.1182/blood-2002-04-1149
   Bokoch GM, 2003, TRENDS BIOCHEM SCI, V28, P502, DOI 10.1016/S0968-0004(03)00194-4
   BORASCHI D, 1985, J IMMUNOL, V135, P502
   Boyum A, 1968, Scand J Clin Lab Invest Suppl, V97, P77
   BROMBERG Y, 1994, J BIOL CHEM, V269, P7055
   Chakraborti T, 1998, MOL CELL BIOCHEM, V187, P1
   COHEN HJ, 1978, J CLIN INVEST, V61, P1088, DOI 10.1172/JCI109008
   Day AP, 1997, ANN CLIN BIOCHEM, V34, P269, DOI 10.1177/000456329703400308
   Delbosc S, 2002, HYPERTENSION, V40, P142, DOI 10.1161/01.HYP.0000024348.87637.6F
   DIEBOLD BA, 1994, BBA-GEN SUBJECTS, V1200, P100, DOI 10.1016/0304-4165(94)90123-6
   Eid HM, 2002, SCAND J CLIN LAB INV, V62, P431, DOI 10.1080/00365510260389985
   El Bekay R, 2003, BLOOD, V102, P662, DOI 10.1182/blood-2002-09-2785
   Estellés R, 2005, J LEUKOCYTE BIOL, V78, P696, DOI 10.1189/jlb.0105048
   Fóris G, 1998, CLIN IMMUNOL IMMUNOP, V86, P95, DOI 10.1006/clin.1997.4452
   GOH EH, 1990, LIPIDS, V25, P738, DOI 10.1007/BF02544043
   GOPALAKRISHNA R, 1986, J BIOL CHEM, V261, P6438
   Hazan-Halevy I, 2005, J HYPERTENS, V23, P1183, DOI 10.1097/01.hjh.0000170381.53955.68
   Hollan S, 1996, HAEMATOLOGIA, V27, P109
   HUWYLER J, 1990, ANAL BIOCHEM, V188, P374, DOI 10.1016/0003-2697(90)90623-H
   JUBIZ W, 1985, J LIQ CHROMATOGR, V8, P1519, DOI 10.1080/01483918508067162
   MACCORMACH J, 1991, CELLULAR CALCIUM PRA, P39
   Ntambi JM, 1996, BIOCHEM BIOPH RES CO, V220, P990, DOI 10.1006/bbrc.1996.0520
   Ntambi JM, 1999, J LIPID RES, V40, P1549
   Paragh G, 1999, J LIPID RES, V40, P1728
   Paragh G, 2002, CELL SIGNAL, V14, P787, DOI 10.1016/S0898-6568(02)00017-7
   Qin S, 2005, J BIOL CHEM, V280, P36773, DOI 10.1074/jbc.M506789200
   RICHARD KM, 2003, CIRCULATION, V108, P1858
   Sampath H, 2005, ANNU REV NUTR, V25, P317, DOI 10.1146/annurev.nutr.25.051804.101917
   Sánchez-Margalet V, 2003, CLIN EXP IMMUNOL, V133, P11, DOI 10.1046/j.1365-2249.2003.02190.x
   SASAKI J, 1994, ARCH BIOCHEM BIOPHYS, V315, P16, DOI 10.1006/abbi.1994.1465
   Seres I, 2005, METABOLISM, V54, P1147, DOI 10.1016/j.metabol.2005.03.021
   Tabor DE, 1998, J BIOL CHEM, V273, P22052, DOI 10.1074/jbc.273.34.22052
   Toyz RM, 2002, BRAZ J MED BIOL RES, V35, P1001, DOI 10.1590/S0100-879X2002000900001
   Underwood KW, 1998, J BIOL CHEM, V273, P21926, DOI 10.1074/jbc.273.34.21926
   UNDERWOOD KW, 1998, J BIOL CHEM, V269, P7005
   Varga Z, 1997, Orv Hetil, V138, P2301
   Wu LH, 2004, ACTA BIOCH BIOPH SIN, V36, P649, DOI 10.1093/abbs/36.10.649
   Zalata AA, 1998, INT J ANDROL, V21, P154
   Zamaria N, 2004, REPROD NUTR DEV, V44, P273, DOI 10.1051/rnd:2004034
   ZHENMIN N, 1994, ENDOCRINOLOGY, V135, P1837
NR 45
TC 15
Z9 15
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0022-2631
EI 1432-1424
J9 J MEMBRANE BIOL
JI J. Membr. Biol.
PD NOV
PY 2006
VL 214
IS 1-2
BP 91
EP 98
DI 10.1007/s00232-006-0020-7
PG 8
WC Biochemistry & Molecular Biology; Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Physiology
GA 189LT
UT WOS:000247991100008
PM 17546512
DA 2025-06-11
ER

PT J
AU Kwak, J
   Seo, IH
   Lee, YJ
AF Kwak, Jiwon
   Seo, In-Ho
   Lee, Yong-Jae
TI Serum γ-glutamyltransferase level and incidence risk of metabolic
   syndrome in community dwelling adults: longitudinal findings over 12
   years
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Metabolic syndrome; gamma-glutamyltransferase; Oxidative stress;
   Epidemiology
ID CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; INDEPENDENT PREDICTOR;
   ASSOCIATION; PREVALENCE; GLUTAMYLTRANSFERASE; MORTALITY; ESTROGEN;
   HEALTH
AB Purpose Although a recent meta-analysis demonstrated a positive association between serum gamma-glutamyltransferase (GGT) and metabolic syndrome (MetS), sex differences in the relationship between GGT levels and MetS risk were not fully considered. We prospectively examined the relationship between serum GGT levels and incidence risk of MetS. Methods Data were collected from the Korean Genome and Epidemiology Study (KoGES) enrolled in 2001-2002. Among 10,030 total participants, 5960 adults (3130 men and 2830 women) aged 40-69 without MetS were included and divided according to sex-specific quartiles of baseline serum GGT levels and followed up biennially until 2014. The hazard ratios (HRs) with 95% confidence intervals (CIs) for incident MetS were prospectively analyzed using multiple Cox proportional hazards regression analysis models. Results Among 5960 participants, 1215 males (38.8%) and 1263 females (44.6%) developed MetS during 12-year follow up. Higher quartiles of GGT showed significantly higher cumulative incidence of MetS in both sexes (log-rank test P < 0.001). The HRs (95% CIs) for incident type 2 diabetes for the highest quartile versus referent lowest quartile for serum GGT levels were 3.01 (2.35-3.76) for men and 1.83 (1.30-2.57) for women after adjusting for age, smoking status, daily alcohol intake (g/day), regular exercise, family history of diabetes, and log-transformed LDL-cholesterol, creatinine, and aminotransferase levels. Conclusion In conclusion, high levels of GGT were found to be associated with increased risk of Mets in both men and women and the positive associations were stronger in men than in women.
C1 [Kwak, Jiwon; Seo, In-Ho; Lee, Yong-Jae] Yonsei Univ, Gangnam Severance Hosp, Dept Family Med, Coll Med, 211 Eonju Ro, Seoul 06273, South Korea.
C3 Yonsei University; Yonsei University Health System
RP Lee, YJ (corresponding author), Yonsei Univ, Gangnam Severance Hosp, Dept Family Med, Coll Med, 211 Eonju Ro, Seoul 06273, South Korea.
EM ukyjhome@yuhs.ac
RI SEO, INHO/HPB-7001-2023
OI Lee, Yong-Jae/0000-0002-6697-476X; Seo, In-Ho/0000-0001-8280-7745
FU National Research Foundation (NRF) - Ministry of Science and ICT of
   Korea [NRF-2022R1A2C1013106]
FX This work was supported by the National Research Foundation (NRF) grant
   funded by the Ministry of Science and ICT of Korea [Grant number:
   NRF-2022R1A2C1013106].The sponsors had no role in the conceptualization
   and design of the study, collection and analysis of data, or writing of
   the article.
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Chung HS, 2019, J CLIN MED, V8, DOI 10.3390/jcm8060832
   Dantas APV, 2005, HYPERTENSION, V46, P21, DOI 10.1161/01.HYP.0000169038.67923.b0
   Ermis H, 2013, POL ARCH MED WEWN, V123, P85, DOI 10.20452/pamw.1617
   Esposito K, 2012, DIABETES CARE, V35, P2402, DOI 10.2337/dc12-0336
   Fasshauer M, 2015, TRENDS PHARMACOL SCI, V36, P461, DOI 10.1016/j.tips.2015.04.014
   Fernández-Real JM, 2012, DIABETOLOGIA, V55, P273, DOI 10.1007/s00125-011-2387-y
   Khalil RA, 2005, HYPERTENSION, V46, P249, DOI 10.1161/01.HYP.0000172945.06681.a4
   Kim Y, 2017, INT J EPIDEMIOL, V46, P1350, DOI 10.1093/ije/dyx105
   Kobayashi H, 2009, AM J PHYSIOL-ENDOC M, V296, pE1326, DOI 10.1152/ajpendo.90921.2008
   Kunutsor SK, 2016, LIVER INT, V36, P1723, DOI 10.1111/liv.13221
   Lazo M, 2008, ANN INTERN MED, V148, P348, DOI 10.7326/0003-4819-148-5-200803040-00005
   Lee DY, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-68603-0
   Lee DH, 2004, FREE RADICAL RES, V38, P535, DOI 10.1080/10715760410001694026
   Lee DS, 2007, ARTERIOSCL THROM VAS, V27, P127, DOI 10.1161/01.ATV.0000251993.20372.40
   Lee JH, 2020, NUTR METAB CARDIOVAS, V30, P1484, DOI 10.1016/j.numecd.2020.04.027
   Lee MY, 2019, ENDOCRINOL METAB, V34, P390, DOI 10.3803/EnM.2019.34.4.390
   Lee YS, 2016, HUM MOL GENET, V25, P3877, DOI 10.1093/hmg/ddw226
   Li DD, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-34913-7
   Li LN, 2021, NUTR DIABETES, V11, DOI 10.1038/s41387-021-00174-z
   Lim S, 2011, DIABETES CARE, V34, P1323, DOI 10.2337/dc10-2109
   Liu CF, 2012, INT J CLIN PRACT, V66, P692, DOI 10.1111/j.1742-1241.2012.02959.x
   LOPEZTORRES M, 1994, J INVEST DERMATOL, V102, P476, DOI 10.1111/1523-1747.ep12373032
   Mauvais-Jarvis F, 2013, ENDOCR REV, V34, P309, DOI 10.1210/er.2012-1055
   Nakanishi N, 2004, DIABETES CARE, V27, P1427, DOI 10.2337/diacare.27.6.1427
   Oh SS, 2018, ALCOHOL, V71, P15, DOI 10.1016/j.alcohol.2018.01.005
   Oh SW, 2008, KOREAN J FAM MED, V29, P838
   Onat A, 2012, OBESITY, V20, P842, DOI 10.1038/oby.2011.136
   Poelzl G, 2009, CIRC-HEART FAIL, V2, P294, DOI 10.1161/CIRCHEARTFAILURE.108.826735
   Rettberg JR, 2014, FRONT NEUROENDOCRIN, V35, P8, DOI 10.1016/j.yfrne.2013.08.001
   Roberts CK, 2013, COMPR PHYSIOL, V3, P1, DOI 10.1002/cphy.c110062
   Ruttmann E, 2005, CIRCULATION, V112, P2130, DOI 10.1161/CIRCULATIONAHA.105.552547
   Ryu S, 2007, ANN EPIDEMIOL, V17, P245, DOI 10.1016/j.annepidem.2006.10.001
   Scholze J, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-529
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Thamer C, 2005, HORM METAB RES, V37, P246, DOI 10.1055/s-2005-861411
   Turgut O, 2011, J ATHEROSCLER THROMB, V18, P177, DOI 10.5551/jat.6189
   Vidaurre J, 2017, PEDIATR NEUROL, V77, P23, DOI 10.1016/j.pediatrneurol.2017.09.013
   Whitfield JB, 2001, CRIT REV CL LAB SCI, V38, P263, DOI 10.1080/20014091084227
   Wilson PWF, 2005, CIRCULATION, V112, P3066, DOI 10.1161/CIRCULATIONAHA.105.539528
   Wu XY, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.644044
   Xu Y, 2011, J DIABETES, V3, P38, DOI 10.1111/j.1753-0407.2010.00111.x
   Yadav D, 2017, YONSEI MED J, V58, P763, DOI 10.3349/ymj.2017.58.4.763
   Yin L, 2014, BIOMED REP, V2, P839, DOI 10.3892/br.2014.356
NR 44
TC 8
Z9 8
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD FEB 23
PY 2023
VL 15
IS 1
DI 10.1186/s13098-023-01000-5
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 9G5DJ
UT WOS:000938172900002
PM 36823659
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lebensztejn, DM
   Flisiak-Jackiewicz, M
   Bialokoz-Kalinowska, I
   Bobrus-Chociej, A
   Kowalska, I
AF Lebensztejn, Dariusz M.
   Flisiak-Jackiewicz, Marta
   Bialokoz-Kalinowska, Irena
   Bobrus-Chociej, Anna
   Kowalska, Irina
TI Hepatokines and non-alcoholic fatty liver disease
SO ACTA BIOCHIMICA POLONICA
LA English
DT Article; Proceedings Paper
CT 43rd Winter School of
   Faculty-of-Biochemistry-Biophysics-and-Biotechnology of
   Jagiellonian-University on Biomolecules - From Structure to Function
CY FEB 16-20, 2016
CL Zakopane, POLAND
SP Jagiellonian Univ, Fac Biochem, Biophys & Biotechnol
DE non-alcoholic fatty liver disease; fetuin-A; fibroblast growth
   factor-21; selenoprotein P; sex hormone-binding globulin;
   angiopoietin-related growth factor; leukocyte derived chemotaxin 2
ID GROWTH-FACTOR 21; HORMONE-BINDING GLOBULIN; HEPATIC INSULIN-RESISTANCE;
   ENDOPLASMIC-RETICULUM STRESS; CARDIOVASCULAR RISK-FACTORS; C3 GENE
   VARIANTS; PLASMA FETUIN-A; METABOLIC SYNDROME; LIPID-METABOLISM;
   SELENOPROTEIN-P
AB Nowadays non-alcoholic fatty liver disease (NAFLD) is becoming the most common chronic liver pathology both in adults and children. NAFLD manifestation ranges from a simple liver steatosis to steatohepatitis (nonalcoholic steatohepatitis - NASH), which may progress to advanced fibrosis, cirrhosis and end-stage liver disease. Due to the coexistence of visceral obesity, insulin resistance and dyslipidemia, NAFLD is considered to be the hepatic manifestation of metabolic syndrome. In recent years, in the pathogenesis of metabolic syndrome, type 2 diabetes mellitus, cardiovascular disease and also NAFLD, more and more attention has been paid to the so-called organokines, proteins with both paracrine or/and endocrine activities. These include most known adipokines (mainly produced by adipose tissue), myokines (mainly produced by skeletal muscles) and hepatokines exclusively or predominantly produced by the liver. It was shown that the liver may affect the lipids and glucose metabolism by hepatokines released into the blood and NAFLD seems to be associated with altered hepatokines production. Fetuin-A, fibroblast growth factor-21 (FGF-21), selenoprotein P, sex hormone-binding globulin (SHBG), angiopoietin-related growth factor (also known as angiopoietin-related protein 6) and leukocyte derived chemotaxin 2 (LECT2) are considered as the most important hepatokines. In this review, we provide an overview of the main hepatokines and we summarize the association of liver-derived proteins with the development and progression of NAFLD.
C1 [Lebensztejn, Dariusz M.; Flisiak-Jackiewicz, Marta; Bobrus-Chociej, Anna] Med Univ Bialystok, Dept Pediat Gastroenterol & Allergol, Bialystok, Poland.
   [Bialokoz-Kalinowska, Irena] Lomza State Univ Appl Sci, Inst Med, Lomza, Poland.
   [Kowalska, Irina] Med Univ Bialystok, Dept Endocrinol Diabetol & Internal Med, Bialystok, Poland.
C3 Medical University of Bialystok; Medical University of Bialystok
RP Lebensztejn, DM (corresponding author), Med Univ Bialystok, Dept Pediat Gastroenterol & Allergol, Bialystok, Poland.
EM lebensztejn@hoga.pl
RI Lebensztejn, Dariusz/AAE-3166-2020; Bobrus- Chociej, ANNA/S-6710-2018;
   Flisiak-Jackiewicz, Marta/U-9368-2018
OI Bobrus- Chociej, ANNA/0000-0003-2143-4978; Kowalska,
   Irina/0000-0001-9281-1959; Flisiak-Jackiewicz, Marta/0000-0001-5157-8708
CR Adams LA, 2005, DIABETIC MED, V22, P1129, DOI 10.1111/j.1464-5491.2005.01748.x
   Alisi A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0067160
   AUBERGER P, 1989, CELL, V58, P631, DOI 10.1016/0092-8674(89)90098-6
   Badman MK, 2007, CELL METAB, V5, P426, DOI 10.1016/j.cmet.2007.05.002
   BERUBE D, 1990, CYTOGENET CELL GENET, V54, P65, DOI 10.1159/000132958
   Birkenfeld AL, 2014, HEPATOLOGY, V59, P713, DOI 10.1002/hep.26672
   Bonnet F, 2013, CLIN ENDOCRINOL, V79, P517, DOI 10.1111/cen.12089
   Burk RF, 2005, ANNU REV NUTR, V25, P215, DOI 10.1146/annurev.nutr.24.012003.132120
   Burke A, 2004, AM J TRANSPLANT, V4, P686, DOI 10.1111/j.1600-6143.2004.00432.x
   Caldwell S, 2010, DIGEST DIS, V28, P162, DOI 10.1159/000282081
   Chartoumpekis DV, 2011, DIABETES, V60, P2465, DOI 10.2337/db11-0112
   Choi HY, 2013, DIABETES METAB J, V37, P63
   Coskun T, 2008, ENDOCRINOLOGY, V149, P6018, DOI 10.1210/en.2008-0816
   Dasgupta S, 2010, BIOCHEM J, V429, P451, DOI 10.1042/BJ20100330
   Denecke B, 2003, BIOCHEM J, V376, P135, DOI 10.1042/BJ20030676
   Díaz-Delfín J, 2012, ENDOCRINOLOGY, V153, P4238, DOI 10.1210/en.2012-1193
   Dogru T, 2013, CLIN ENDOCRINOL, V78, P712, DOI 10.1111/j.1365-2265.2012.04460.x
   Dongiovanni P, 2013, CURR PHARM DESIGN, V19, P5219, DOI 10.2174/13816128113199990381
   Dushay J, 2010, GASTROENTEROLOGY, V139, P456, DOI 10.1053/j.gastro.2010.04.054
   Ebert T, 2014, HORM METAB RES, V46, P685, DOI 10.1055/s-0034-1382078
   Ebert T, 2009, METABOLISM, V58, P547, DOI 10.1016/j.metabol.2008.11.016
   Ertle J, 2011, INT J CANCER, V128, P2436, DOI 10.1002/ijc.25797
   Fisher FM, 2014, GASTROENTEROLOGY, V147, P1073, DOI 10.1053/j.gastro.2014.07.044
   Flechtner-Mors M, 2014, HORM METAB RES, V46, P287, DOI 10.1055/s-0033-1354369
   Fletcher JA, 2012, APPL PHYSIOL NUTR ME, V37, P1054, DOI [10.1139/h2012-091, 10.1139/H2012-091]
   Gaich G, 2013, CELL METAB, V18, P333, DOI 10.1016/j.cmet.2013.08.005
   Gaudio E, 2012, INTERN EMERG MED, V7, pS297, DOI 10.1007/s11739-012-0826-5
   Giannini C, 2013, J CLIN ENDOCR METAB, V98, P2993, DOI 10.1210/jc.2013-1250
   Haukeland JW, 2012, EUR J ENDOCRINOL, V166, P503, DOI 10.1530/EJE-11-0864
   Haukeland JW, 2009, SCAND J GASTROENTERO, V44, P853, DOI 10.1080/00365520902845268
   Heinrichsdorff J, 2012, NAT MED, V18, P1182, DOI 10.1038/nm.2869
   Heuer M, 2012, DIGESTION, V86, P107, DOI 10.1159/000339344
   Hill KE, 1996, GENOMICS, V36, P550, DOI 10.1006/geno.1996.0505
   Hua XM, 2014, CLIN ENDOCRINOL, V80, P877, DOI 10.1111/cen.12360
   Hui E, 2013, J DIABETES INVEST, V4, P413, DOI 10.1111/jdi.12093
   Jiang S, 2014, J NUTRIGENET NUTRIGE, V7, P121, DOI 10.1159/000367943
   Jiang S, 2014, J BIOL CHEM, V289, P29751, DOI 10.1074/jbc.M114.565960
   Kadomatsu T, 2011, FEBS J, V278, P559, DOI 10.1111/j.1742-4658.2010.07979.x
   Kahraman A, 2013, CLIN SCI, V125, P391, DOI 10.1042/CS20120542
   Kantartzis K, 2009, DIABETES, V58, P2616, DOI 10.2337/db09-0279
   Kavanagh K, 2013, OBESITY, V21, P1031, DOI 10.1002/oby.20077
   KHAN MS, 1981, J CLIN ENDOCR METAB, V53, P448, DOI 10.1210/jcem-53-2-448
   Kharitonenkov A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0058575
   Kim SH, 2015, DIABETOLOGIA, V58, P809, DOI 10.1007/s00125-014-3475-6
   Kitazawa M, 2007, J PHARMACOL EXP THER, V323, P787, DOI 10.1124/jpet.107.127530
   Kumashiro N, 2011, P NATL ACAD SCI USA, V108, P16381, DOI 10.1073/pnas.1113359108
   Lan F, 2014, DIABETES, V63, P1649, DOI 10.2337/db13-0728
   Lazo M, 2015, CLIN GASTROENTEROL H, V13, P1686, DOI 10.1016/j.cgh.2014.12.033
   Lebensztejn DM, 2014, ADV MED SCI-POLAND, V59, P81, DOI 10.1016/j.advms.2013.08.003
   Lebensztejn DM, 2016, HEPATOL INT S1, V10, P398
   Lee J, 2014, METABOLISM, V63, P1041, DOI 10.1016/j.metabol.2014.04.011
   Li HT, 2013, FRONT MED-PRC, V7, P25, DOI 10.1007/s11684-013-0244-8
   Li HT, 2013, J HEPATOL, V58, P557, DOI 10.1016/j.jhep.2012.10.029
   Li HT, 2010, J HEPATOL, V53, P934, DOI 10.1016/j.jhep.2010.05.018
   Li K, 2012, MOL CELL ENDOCRINOL, V348, P21, DOI 10.1016/j.mce.2011.07.026
   Liu J, 2015, METABOLISM, V64, P380, DOI 10.1016/j.metabol.2014.11.009
   Malin SK, 2013, J APPL PHYSIOL, V115, P988, DOI 10.1152/japplphysiol.00237.2013
   Mathews ST, 2002, DIABETES, V51, P2450, DOI 10.2337/diabetes.51.8.2450
   Misu H, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034952
   Misu H, 2010, CELL METAB, V12, P483, DOI 10.1016/j.cmet.2010.09.015
   Mori K, 2006, DIABETES CARE, V29, P468, DOI 10.2337/diacare.29.02.06.dc05-1484
   Mori K, 2012, ADV CLIN CHEM, V56, P175, DOI 10.1016/B978-0-12-394317-0.00010-8
   Mori K, 2011, RECENT PATENTS ENDOC, V5, P124, DOI 10.2174/187221411799015372
   Mu J, 2012, DIABETES, V61, P505, DOI 10.2337/db11-0838
   Namkung J, 2011, METABOLISM, V60, P564, DOI 10.1016/j.metabol.2010.05.013
   Nishimura T, 2000, BBA-GENE STRUCT EXPR, V1492, P203, DOI 10.1016/S0167-4781(00)00067-1
   Oike Y, 2005, NAT MED, V11, P400, DOI 10.1038/nm1214
   Oike Y, 2003, P NATL ACAD SCI USA, V100, P9494, DOI 10.1073/pnas.1531901100
   Okumura A, 2013, BIOSCI TRENDS, V7, P276, DOI 10.5582/bst.2013.v7.6.276
   Oral EA, 2002, NEW ENGL J MED, V346, P570, DOI 10.1056/NEJMoa012437
   Ou HY, 2012, J CLIN ENDOCR METAB, V97, P4717, DOI 10.1210/jc.2012-2414
   Pacifico L, 2011, WORLD J GASTROENTERO, V17, P3082, DOI 10.3748/wjg.v17.i26.3082
   Pal D, 2012, NAT MED, V18, P1279, DOI 10.1038/nm.2851
   Parola M, 2011, ANTIOXID REDOX SIGN, V15, P461, DOI 10.1089/ars.2010.3848
   Pedersen KO, 1944, NATURE, V154, P575, DOI 10.1038/154575a0
   Perry RJ, 2014, NATURE, V510, P84, DOI 10.1038/nature13478
   Peter A, 2012, INT J OBESITY, V36, P774, DOI 10.1038/ijo.2011.154
   Peter A, 2010, DIABETES, V59, P3167, DOI 10.2337/db10-0179
   Petersen KF, 2010, NEW ENGL J MED, V362, P1082, DOI 10.1056/NEJMoa0907295
   Polyzos SA, 2013, HORM-INT J ENDOCRINO, V12, P405, DOI 10.1007/BF03401306
   Raddatz K, 2011, DIABETOLOGIA, V54, P1447, DOI 10.1007/s00125-011-2073-0
   Raschke S, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/320724
   Reinehr T, 2008, J CLIN ENDOCR METAB, V93, P4479, DOI 10.1210/jc.2008-1505
   Reinehr T, 2012, J CLIN ENDOCR METAB, V97, P2143, DOI 10.1210/jc.2012-1221
   Roden M, 2006, NAT CLIN PRACT ENDOC, V2, P335, DOI 10.1038/ncpendmet0190
   Romeo S, 2008, NAT GENET, V40, P1461, DOI 10.1038/ng.257
   Roos M, 2010, AM J CARDIOL, V105, P1666, DOI 10.1016/j.amjcard.2010.01.342
   Samuel VT, 2004, J BIOL CHEM, V279, P32345, DOI 10.1074/jbc.M313478200
   Sato M, 2015, LIVER INT, V35, P925, DOI 10.1111/liv.12478
   Shen JY, 2012, J HEPATOL, V56, P1363, DOI 10.1016/j.jhep.2011.12.025
   Shin JY, 2011, DIABETES RES CLIN PR, V94, P156, DOI 10.1016/j.diabres.2011.07.029
   Siddiq A, 2005, DIABETES, V54, P2477, DOI 10.2337/diabetes.54.8.2477
   Simó R, 2015, TRENDS ENDOCRIN MET, V26, P376, DOI 10.1016/j.tem.2015.05.001
   Simó R, 2014, ENDOCRINOLOGY, V155, P2820, DOI 10.1210/en.2014-1072
   SRINIVAS PR, 1993, MOL ENDOCRINOL, V7, P1445, DOI 10.1210/me.7.11.1445
   Stefan N, 2006, DIABETES CARE, V29, P853, DOI 10.2337/diacare.29.04.06.dc05-1938
   Stefan N, 2014, NEW ENGL J MED, V371, P2236, DOI 10.1056/NEJMc1412427
   Stefan N, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0092238
   Stefan N, 2013, NAT MED, V19, P394, DOI 10.1038/nm.3116
   Stefan N, 2013, NAT REV ENDOCRINOL, V9, P144, DOI 10.1038/nrendo.2012.258
   Stefan N, 2009, NEW ENGL J MED, V361, P2675, DOI 10.1056/NEJMc0910143
   Stefan N, 2008, ENDOCR REV, V29, P939, DOI 10.1210/er.2008-0009
   Sutton-Tyrrell K, 2005, CIRCULATION, V111, P1242, DOI 10.1161/01.CIR.0000157697.54255.CE
   Tacer KF, 2010, MOL ENDOCRINOL, V24, P2050, DOI 10.1210/me.2010-0142
   Takata H, 2009, J ATHEROSCLER THROMB, V16, P448, DOI 10.5551/jat.No950
   Tanaka N, 2015, BBA-MOL BASIS DIS, V1852, P1242, DOI 10.1016/j.bbadis.2015.02.012
   Targher G, 2005, DIABETES, V54, P3541, DOI 10.2337/diabetes.54.12.3541
   Targher G, 2010, NEW ENGL J MED, V363, P1341, DOI 10.1056/NEJMra0912063
   Vernon G, 2011, ALIMENT PHARM THER, V34, P274, DOI 10.1111/j.1365-2036.2011.04724.x
   Weikert C, 2008, CIRCULATION, V118, P2555, DOI 10.1161/CIRCULATIONAHA.108.814418
   Xu J, 2009, DIABETES, V58, P250, DOI 10.2337/db08-0392
   Yamagoe S, 1998, BBA-GENE STRUCT EXPR, V1396, P105, DOI 10.1016/S0167-4781(97)00181-4
   Yamagoe S, 1996, IMMUNOL LETT, V52, P9, DOI 10.1016/0165-2478(96)02572-2
   Yan HM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024895
   Yang SJ, 2011, J CLIN ENDOCR METAB, V96, pE1325, DOI 10.1210/jc.2011-0620
   Yilmaz Y, 2010, ANN CLIN BIOCHEM, V47, P549, DOI 10.1258/acb.2010.010169
   Yilmaz Y, 2010, EUR J CLIN INVEST, V40, P887, DOI 10.1111/j.1365-2362.2010.02338.x
   Yoo HJ, 2015, DIABETES METAB J, V39, P10, DOI 10.4093/dmj.2015.39.1.10
   Yu CL, 2002, J BIOL CHEM, V277, P50230, DOI 10.1074/jbc.M200958200
   Zhang J, 2015, FRONT ENDOCRINOL, V6, DOI 10.3389/fendo.2015.00168
   Zhang Y, 2011, COMPUT MATH METHOD M, V2011, DOI 10.1155/2011/173748
NR 121
TC 71
Z9 73
U1 1
U2 16
PU ACTA BIOCHIMICA POLONICA
PI WARSAW
PA PASTEURA 3, 02-093 WARSAW, POLAND
SN 0001-527X
EI 1734-154X
J9 ACTA BIOCHIM POL
JI Acta Biochim. Pol.
PY 2016
VL 63
IS 3
BP 459
EP 467
DI 10.18388/abp.2015_1252
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Biochemistry & Molecular Biology
GA EB7YH
UT WOS:000387606800010
PM 27262842
OA gold
DA 2025-06-11
ER

PT J
AU Abete, I
   Goyenechea, E
   Zulet, MA
   Martínez, JA
AF Abete, I.
   Goyenechea, E.
   Zulet, M. A.
   Martinez, J. A.
TI Obesity and metabolic syndrome: Potential benefit from specific
   nutritional components
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Review
DE Metabolic syndrome; Dietary treatment; Obesity; Antioxidants; Minerals
   and vitamins
ID ENERGY-RESTRICTED DIETS; LOW-GLYCEMIC INDEX; ORAL MAGNESIUM
   SUPPLEMENTATION; POSTPRANDIAL INSULIN-RESPONSE; POLYUNSATURATED
   FATTY-ACIDS; DISEASE RISK-FACTORS; WEIGHT-LOSS; CARDIOVASCULAR-DISEASE;
   BLOOD-PRESSURE; ANTIOXIDANT STATUS
AB The prevalence of metabolic syndrome (MetS) manifestations is rapidly increasing worldwide, and is becoming an important health problem. Actually, MetS includes a combination of clinical complications such as obesity (central adiposity), insulin resistance, glucose intolerance, dyslipidemia, non-alcoholic fatty liver disease and hypertension. All these alterations predispose individuals to type 2 diabetes and cardiovascular disease inducing earlier mortality rates among people.
   In general terms, it is difficult for patients to follow a standard long-term diet/exercise regime that would improve or alleviate MetS symptoms. Thus, the investigation of food components that may deal with the MetS features is an important field for ameliorate and facilitate MetS dietary-based therapies. Currently antioxidants are of great interest due to the described association between obesity, cardiovascular alterations and oxidative stress. On the other hand, high MUFA and PUFA diets are being also considered due to their potential benefits on hypertension, insulin resistance and triglyceride levels. Mineral composition of the diet is also relevant since high potassium intake may improve hypertension and high calcium consumption may promote lipid oxidation. Thus, although nutritional supplements are at the peak of dietetic therapies, the consumption of some specific foods (legumes, fatty fish, vegetables and fruits, etc) with bioactive components within an energy-restricted diet is a promising approach to manage MetS manifestations. Therefore, the present review focuses on some of the most important food components currently investigated to improve and make easier the nutritional MetS treatment. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Goyenechea, E.] Colegio Oficial Farmaceut, San Sebastian, Spain.
   [Abete, I.; Zulet, M. A.; Martinez, J. A.] Univ Navarra, Dept Ciencias Alimentac Fisiol & Toxicol, E-31080 Pamplona, Navarra, Spain.
C3 University of Navarra
RP Martínez, JA (corresponding author), Univ Navarra, Dept Ciencias Alimentac Fisiol & Toxicol, C Irunlarrea 1, E-31080 Pamplona, Navarra, Spain.
EM jalftmtz@unav.es
RI Martinez, Juan/GXM-4393-2022; Abete, Itziar/H-4827-2017; Zulet, M.
   Angeles/H-1317-2017; Martinez Hernandez, J Alfredo/K-8709-2014
OI ESTIBALIZ, GOYENECHEA/0000-0001-7990-5192; Abete,
   Itziar/0000-0002-6475-5387; Zulet, M. Angeles/0000-0002-3926-0892;
   Martinez Hernandez, J Alfredo/0000-0001-5218-6941
CR Abete I, 2008, J HUM NUTR DIET, V21, P591, DOI 10.1111/j.1365-277X.2008.00902.x
   Abete I, 2008, CLIN NUTR, V27, P545, DOI 10.1016/j.clnu.2008.01.005
   Alonso A, 2005, AM J CLIN NUTR, V82, P972, DOI 10.1093/ajcn/82.5.972
   Alonso A, 2009, J HUM NUTR DIET, V22, P336, DOI 10.1111/j.1365-277X.2009.00967.x
   Anderson J W, 2000, Curr Atheroscler Rep, V2, P536, DOI 10.1007/s11883-000-0055-7
   Zulet MA, 2009, NUTR RES, V29, P41, DOI 10.1016/j.nutres.2008.11.003
   Astrup A, 2010, ANN NY ACAD SCI, V1190, P25, DOI 10.1111/j.1749-6632.2009.05272.x
   Azadbakht L, 2005, DIABETES CARE, V28, P2823, DOI 10.2337/diacare.28.12.2823
   Azadbakht L, 2007, BRIT J NUTR, V98, P807, DOI 10.1017/S0007114507746871
   Babio N, 2009, NUTR METAB CARDIOVAS, V19, P563, DOI 10.1016/j.numecd.2008.10.007
   Barclay AW, 2008, AM J CLIN NUTR, V87, P627, DOI 10.1093/ajcn/87.3.627
   Bazzano LA, 2011, NUTR METAB CARDIOVAS, V21, P94, DOI 10.1016/j.numecd.2009.08.012
   Bertelli AAA, 2009, J CARDIOVASC PHARM, V54, P468, DOI 10.1097/FJC.0b013e3181bfaff3
   Bes-Rastrollo M, 2007, OBESITY, V15, P107, DOI 10.1038/oby.2007.507
   Boon N, 2008, INT J VITAM NUTR RES, V78, P275, DOI 10.1024/0300-9831.78.6.275
   Brand-Miller J, 2008, ASIA PAC J CLIN NUTR, V17, P16
   Bressan J, 2009, ARQ BRAS ENDOCRINOL, V53, P572, DOI 10.1590/S0004-27302009000500010
   Brown AL, 2009, BRIT J NUTR, V101, P886, DOI 10.1017/S0007114508047727
   Bruce KD, 2010, J NUTR, V140, P648, DOI 10.3945/jn.109.111179
   Buckley JD, 2009, OBES REV, V10, P648, DOI 10.1111/j.1467-789X.2009.00584.x
   Cacciapuoti F, 2009, METAB SYNDR RELAT D, V7, P397, DOI 10.1089/met.2008.0057
   Campbell MJ, 2004, EUR J CLIN NUTR, V58, P173, DOI 10.1038/sj.ejcn.1601764
   Cao GH, 1998, J NUTR, V128, P2383, DOI 10.1093/jn/128.12.2383
   Casas-Agustench P, 2011, NUTR METAB CARDIOVAS, V21, P126, DOI 10.1016/j.numecd.2009.08.005
   Catania AS, 2009, ARQ BRAS ENDOCRINOL, V53, P550, DOI 10.1590/S0004-27302009000500008
   Christen WG, 2000, ANN EPIDEMIOL, V10, P125, DOI 10.1016/S1047-2797(99)00042-3
   Cicero AFG, 2010, CLIN EXP HYPERTENS, V32, P137, DOI 10.3109/10641960903254448
   Cicero AFG, 2009, CURR VASC PHARMACOL, V7, P330, DOI 10.2174/157016109788340659
   Clarke R, 2002, CARDIOVASC DRUG THER, V16, P411, DOI 10.1023/A:1022134418372
   Corica F, 2006, J AM COLL NUTR, V25, P210, DOI 10.1080/07315724.2006.10719534
   Covas MI, 2006, ANN INTERN MED, V145, P333, DOI 10.7326/0003-4819-145-5-200609050-00006
   Crujeiras AB, 2007, FREE RADICAL RES, V41, P498, DOI 10.1080/10715760601131935
   Crujeiras AB, 2006, NUTRITION, V22, P593, DOI 10.1016/j.nut.2006.03.008
   Czernichow S, 2009, AM J CLIN NUTR, V90, P329, DOI 10.3945/ajcn.2009.27635
   De Rougemont A, 2007, BRIT J NUTR, V98, P1288, DOI 10.1017/S0007114507778674
   Devaraj S, 2007, AM J CLIN NUTR, V86, P1392
   Domingo JL, 2007, ENVIRON INT, V33, P993, DOI 10.1016/j.envint.2007.05.001
   Druet C, 2010, HORM RES PAEDIAT, V73, P181, DOI 10.1159/000284359
   Ebbesson Sven O E, 2007, J Cardiometab Syndr, V2, P244, DOI 10.1111/j.1559-4564.2007.07393.x
   Ebbesson Sven O E, 2005, Int J Circumpolar Health, V64, P387
   Ebbesson Sven O E, 2005, Int J Circumpolar Health, V64, P396
   Egert S, 2009, BRIT J NUTR, V102, P1065, DOI 10.1017/S0007114509359127
   Erkkilä AT, 2008, EUR J NUTR, V47, P319, DOI 10.1007/s00394-008-0728-5
   Estruch R, 2011, NUTR METAB CARDIOVAS, V21, P46, DOI 10.1016/j.numecd.2009.07.006
   Fitó M, 2007, MOL NUTR FOOD RES, V51, P1215, DOI 10.1002/mnfr.200600308
   Flint A, 2006, AM J CLIN NUTR, V84, P1365, DOI 10.1093/ajcn/84.6.1365
   Ganji V, 2004, ETHNIC DIS, V14, P476
   Guerrera MP, 2009, AM FAM PHYSICIAN, V80, P157
   Guerrero-Romero F, 2002, ACTA DIABETOL, V39, P209, DOI 10.1007/s005920200036
   He K, 2006, CIRCULATION, V113, P1675, DOI 10.1161/CIRCULATIONAHA.105.588327
   He Ka, 2006, J Cardiometab Syndr, V1, P351, DOI 10.1111/j.1559-4564.2006.05702.x
   Ikeda I, 2008, ASIA PAC J CLIN NUTR, V17, P273
   Jenkins DJA, 2008, JAMA-J AM MED ASSOC, V300, P2742, DOI 10.1001/jama.2008.808
   Juntunen KS, 2003, AM J CLIN NUTR, V78, P957, DOI 10.1093/ajcn/78.5.957
   Kabir M, 1998, J NUTR, V128, P1878, DOI 10.1093/jn/128.11.1878
   Kataja-Tuomola M, 2008, DIABETOLOGIA, V51, P47, DOI 10.1007/s00125-007-0864-0
   Krauss RM, 2000, CIRCULATION, V102, P2284
   Lamarche B, 2008, J AM COLL NUTR, V27, p741S, DOI 10.1080/07315724.2008.10719752
   Larsen Thomas Meinert, 2010, N Engl J Med, V363, P2102, DOI 10.1056/NEJMoa1007137
   Lee K, 2009, INT J CLIN PRACT, V63, P195, DOI 10.1111/j.1742-1241.2008.01965.x
   Leinonen K, 1999, EUR J CLIN NUTR, V53, P262, DOI 10.1038/sj.ejcn.1600716
   Li TY, 2009, J NUTR, V139, P1333, DOI 10.3945/jn.108.103622
   Lichtenstein A, 2006, CIRCULATION, V114, pE629, DOI 10.1161/CIRCULATIONAHA.106.180281
   Lindström J, 2010, PUBLIC HEALTH NUTR, V13, P993, DOI 10.1017/S1368980010000960
   Liu Ling, 2008, Endocrine Metabolic & Immune Disorders-Drug Targets, V8, P89, DOI 10.2174/187153008784534385
   Lutsey PL, 2008, CIRCULATION, V117, P754, DOI 10.1161/CIRCULATIONAHA.107.716159
   Malvy DJM, 2001, CANCER DETECT PREV, V25, P479
   Marqués M, 2008, MED CLIN-BARCELONA, V130, P10, DOI 10.1157/13114541
   Martinez MA, 2008, METABOLISM, V57, P1232, DOI 10.1016/j.metabol.2008.04.017
   Martínez-González MA, 2006, ALTERN THER HEALTH M, V12, P24
   Martinez-Gonzalez MA, 2006, ALTERN THER HEALTH M, V12, P31
   Mcbride PE, 2008, J NUTR HEALTH AGING, V12, p745S
   McKeown NM, 2008, EUR J NUTR, V47, P210, DOI 10.1007/s00394-008-0715-x
   Micallef M, 2007, NUTR J, V6, DOI 10.1186/1475-2891-6-27
   Moore RJ, 2009, BRIT J NUTR, V102, P1790, DOI 10.1017/S0007114509991218
   Mori TA, 2004, J HYPERTENS, V22, P1983, DOI 10.1097/00004872-200410000-00022
   Mostad IL, 2009, METABOLISM, V58, P1753, DOI 10.1016/j.metabol.2009.06.003
   Muzio F, 2007, AM J CLIN NUTR, V86, P946, DOI 10.1093/ajcn/86.4.946
   Noll C, 2009, FOOD CHEM TOXICOL, V47, P230, DOI 10.1016/j.fct.2008.11.005
   Oshaug A, 1998, EUR J CLIN NUTR, V52, P7, DOI 10.1038/sj.ejcn.1600505
   Paniagua JA, 2007, J AM COLL NUTR, V26, P434, DOI 10.1080/07315724.2007.10719633
   PAOLISSO G, 1989, ACTA ENDOCRINOL-COP, V121, P16, DOI 10.1530/acta.0.1210016
   Parks EJ, 2000, AM J CLIN NUTR, V71, P412
   PARRA D, 2007, EUR J NUTR, V46, P460, DOI DOI 10.1007/S00394-007-0686-3
   Partida-Hernández G, 2006, BIOMED PHARMACOTHER, V60, P161, DOI 10.1016/j.biopha.2006.02.004
   Pereira MA, 2009, INT J ENV RES PUB HE, V6, P2568, DOI 10.3390/ijerph6102568
   Pérez-Jiménez F, 2007, MOL NUTR FOOD RES, V51, P1199, DOI [10.1002/mnfr.200600273, 10.1002/mnfr.200790023]
   Pfeuffer M, 2007, OBES REV, V8, P109, DOI 10.1111/j.1467-789X.2006.00265.x
   Phillips CM, 2010, J LIPID RES, V51, P1793, DOI 10.1194/jlr.M003046
   Phung OJ, 2009, J AM DIET ASSOC, V109, P865, DOI 10.1016/j.jada.2009.02.014
   Puchau B, 2009, EUR J CLIN NUTR, V63, P858, DOI 10.1038/ejcn.2008.48
   Puchau B, 2010, NUTRITION, V26, P534, DOI 10.1016/j.nut.2009.06.017
   Ramel A, 2009, EUR J NUTR, V48, P107, DOI 10.1007/s00394-008-0769-9
   Razquin C, 2009, EUR J CLIN NUTR, V63, P1387, DOI 10.1038/ejcn.2009.106
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Rivera L, 2009, BIOCHEM PHARMACOL, V77, P1053, DOI 10.1016/j.bcp.2008.11.027
   Rizkalla SW, 2002, BRIT J NUTR, V88, pS255, DOI 10.1079/BJN2002715
   Rodríguez MC, 2005, PLANT FOOD HUM NUTR, V60, P219, DOI 10.1007/s11130-005-8622-2
   Rodríguez-Morán M, 2003, DIABETES CARE, V26, P1147, DOI 10.2337/diacare.26.4.1147
   Ros E, 2009, AM J CLIN NUTR, V89, pS1649, DOI 10.3945/ajcn.2009.26736R
   Ryan E, 2006, INT J FOOD SCI NUTR, V57, P219, DOI 10.1080/09637480600768077
   Sadruddin Sarfaraz, 2009, J Cardiometab Syndr, V4, P102, DOI 10.1111/j.1559-4572.2008.00039.x
   Samman S, 2009, J WOMENS HEALTH, V18, P1813, DOI 10.1089/jwh.2008.1201
   Scribner KB, 2008, AM J PHYSIOL-ENDOC M, V295, pE1126, DOI 10.1152/ajpendo.90487.2008
   Scribner KB, 2007, OBESITY, V15, P2190, DOI 10.1038/oby.2007.260
   Shahar DR, 2007, DIABETES CARE, V30, P485, DOI 10.2337/dc06-1564
   Shai I, 2008, NEW ENGL J MED, V359, P229, DOI 10.1056/NEJMoa0708681
   Shenoy SF, 2010, NUTR J, V9, DOI 10.1186/1475-2891-9-8
   Singh RB, 1998, J AM COLL NUTR, V17, P564, DOI 10.1080/07315724.1998.10718804
   Sirtori CR, 2009, NUTR RES REV, V22, P244, DOI 10.1017/S0954422409990187
   Song Y, 2006, DIABETIC MED, V23, P1050, DOI 10.1111/j.1464-5491.2006.01852.x
   Song Y, 2005, BIOMETALS, V18, P325, DOI 10.1007/s10534-005-3689-7
   Soory Mena, 2009, Infectious Disorders - Drug Targets, V9, P400
   Spanou C, 2010, J MED FOOD, V13, P149, DOI 10.1089/jmf.2009.0058
   Steemburgo T, 2007, ARQ BRAS ENDOCRINOL, V51, P1425, DOI 10.1590/S0004-27302007000900004
   Taku K, 2007, AM J CLIN NUTR, V85, P1148, DOI 10.1093/ajcn/85.4.1148
   Teegarden D, 2008, OBESITY, V16, P1566, DOI 10.1038/oby.2008.232
   Tholstrup T, 2006, CURR OPIN LIPIDOL, V17, P1, DOI 10.1097/01.mol.0000199813.08602.58
   Thorsdottir I, 2007, INT J OBESITY, V31, P1560, DOI 10.1038/sj.ijo.0803643
   Tremblay A, 2009, J AM COLL NUTR, V28, p91S, DOI 10.1080/07315724.2009.10719809
   Trinidad TP, 2010, BRIT J NUTR, V103, P569, DOI 10.1017/S0007114509992157
   van Meijl LEC, 2008, NUTR RES REV, V21, P148, DOI 10.1017/S0954422408116997
   Vernaglione L, 2009, J NEPHROL, V22, pS149
   Vessby B, 2001, DIABETOLOGIA, V44, P312, DOI 10.1007/s001250051620
   Wennersberg MH, 2009, AM J CLIN NUTR, V90, P960, DOI 10.3945/ajcn.2009.27664
   Woodside JV, 2005, P NUTR SOC, V64, P554, DOI 10.1079/PNS2005465
   Wu JHY, 2007, CLIN CHEM, V53, P511, DOI 10.1373/clinchem.2006.076992
   Zemel M, 2003, OBES RES, V11, P375, DOI 10.1038/oby.2003.50
   Zemel MB, 2000, FASEB J, V14, P1132, DOI 10.1096/fasebj.14.9.1132
   Zemel MB, 2004, NUTR REV, V62, P125, DOI [10.1301/nr.2004.apr.125–131, 10.1111/j.1753-4887.2004.tb00034.x, 10.1301/nr.2004.apr.125-131]
   Zemel MB, 2001, J AM COLL NUTR, V20, p428S, DOI 10.1080/07315724.2001.10719180
   Zemel MB, 2009, PHYSICIAN SPORTSMED, V37, P29, DOI 10.3810/psm.2009.06.1707
   Zern TL, 2005, J NUTR, V135, P1911, DOI 10.1093/jn/135.8.1911
   Zhan SY, 2005, AM J CLIN NUTR, V81, P397
   Zhuo XG, 2004, J NUTR, V134, P2395, DOI 10.1093/jn/134.9.2395
NR 135
TC 161
Z9 179
U1 2
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD SEP
PY 2011
VL 21
SU 2
BP B1
EP B15
DI 10.1016/j.numecd.2011.05.001
PG 15
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 816LL
UT WOS:000294601300001
PM 21764273
DA 2025-06-11
ER

PT J
AU Rossoni, G
   Manfredi, B
   Tazzari, V
   Sparatore, A
   Trivulzio, S
   Del Soldato, P
   Berti, F
AF Rossoni, Giuseppe
   Manfredi, Barbara
   Tazzari, Valerio
   Sparatore, Anna
   Trivulzio, Silvio
   Del Soldato, Piero
   Berti, Ferruccio
TI Activity of a new hydrogen sulfide-releasing aspirin (ACS14) on
   pathological cardiovascular alterations induced by glutathione depletion
   in rats
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE H2S-releasing aspirin; Glutathione depletion; Metabolic syndrome;
   Hypertension; Ischemia/reperfusion
ID OXIDATIVE STRESS; METABOLIC SYNDROME; INSULIN-RESISTANCE; INFLAMMATION;
   ATHEROSCLEROSIS; HYPERTENSION; DYSFUNCTION; INHIBITION; MARKERS
AB We investigated the effects of the hydrogen sulfide (H2S)-releasing derivatives of aspirin (ACS14) and salicylic acid (ACS21) in a rat model of metabolic syndrome induced by glutathione (GSH) depletion, causing hypertension and other pathological cardiovascular alterations. GSH depletion was induced in normal rats by the GSH-synthase inhibitor buthionine sulfoximine (BSO, 30 mmol/L day for seven days in the drinking water). Systolic blood pressure and heart rate were measured daily by the tail-cuff method, and plasma thromboxane B-2, 6-keto-prostaglandin F-2 alpha, 8-isoprostane, GSH, insulin and glucose were determined at the end of the seven-day BSO schedule. In addition. ischemia/reperfusion-induced myocardial dysfunction and endothelial dysfunction were assayed on isolated heart and aortic rings, respectively. Unlike aspirin and salicylic acid, ACS14 and ACS21 reduced BSO-induced hypertension, also lowering plasma levels of thromboxane B-2, 8-isoprostane and insulin, while GSH remained in the control range. Neither ACS14 nor ACS21 caused gastric lesions. Both restored the endothelial dysfunction observed in aortic rings from BSO-treated rats, and in ischemia/reperfusion experiments they lowered left ventricular end-diastolic pressure, consequently improving the developed pressure and the maximum rise and fall of left ventricular pressure. Together with this improvement of heart mechanics there were reductions in the activity of creatine kinase and lactate dehydrogenase in the cardiac perfusate. This implies that H2S released by both ACS14 and ACS21 was involved in protecting the heart from ischemia/reperfusion, and significantly limited vascular endothelial dysfunction in aortic tissue and the related hypertension. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Rossoni, Giuseppe; Manfredi, Barbara; Trivulzio, Silvio; Berti, Ferruccio] Univ Milan, Dipartimento Farmacol Chemioterapia & Tossicol Me, I-20129 Milan, Italy.
   [Tazzari, Valerio; Sparatore, Anna] Univ Milan, Dipartimento Sci Farmaceut Pietro Pratesi, I-20129 Milan, Italy.
   [Del Soldato, Piero] CTG Pharma, Milan, Italy.
C3 University of Milan; University of Milan
RP Rossoni, G (corresponding author), Univ Milan, Dipartimento Farmacol Chemioterapia & Tossicol Me, Via Vanvitelli 32, I-20129 Milan, Italy.
EM giuseppe.sossoni@unimi.it
RI ; Sparatore, Anna/J-8634-2015
OI MANFREDI, BARBARA/0000-0002-5115-4291; Sparatore,
   Anna/0000-0003-2135-2649
FU CTG Pharma
FX Dr. Piero Del Soldato is a shareholder of CTG Pharma, Milan, Italy. This
   company has patents on reagents used in this study. Professor Anna
   Sparatore received a grant from CTG Pharma.
CR Ando K, 2009, FREE RADICAL BIO MED, V47, P213, DOI 10.1016/j.freeradbiomed.2009.04.030
   BAKER MA, 1990, ANAL BIOCHEM, V190, P360, DOI 10.1016/0003-2697(90)90208-Q
   Bayorh MA, 2003, AM J HYPERTENS, V16, P387, DOI 10.1016/S0895-7061(03)00054-2
   Becker JC, 2004, BRIT J CLIN PHARMACO, V58, P587, DOI 10.1111/j.1365-2125.2004.02198.x
   BERGMEYER HU, 1970, Z KLIN CHEM KLIN BIO, V8, P658
   Berry C, 2001, CURR OPIN NEPHROL HY, V10, P247, DOI 10.1097/00041552-200103000-00014
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   ESTERBAUER H, 1991, FREE RADICAL BIO MED, V11, P81, DOI 10.1016/0891-5849(91)90192-6
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Giustarini D, 2010, FREE RADICAL BIO MED, V48, P1263, DOI 10.1016/j.freeradbiomed.2010.02.014
   HOHORST HJ, 1963, METHOD ENZYMAT AN, P215
   Khamaisi M, 2000, BIOCHEM J, V349, P579, DOI 10.1042/bj3490579
   Khan BV, 2004, DIABETES CARE, V27, P1712, DOI 10.2337/diacare.27.7.1712
   Li L, 2007, FREE RADICAL BIO MED, V42, P706, DOI 10.1016/j.freeradbiomed.2006.12.011
   Libby P, 2002, CIRCULATION, V105, P1135, DOI 10.1161/hc0902.104353
   MEISTER A, 1983, SCIENCE, V220, P472, DOI 10.1126/science.6836290
   Ogihara T, 2004, DIABETOLOGIA, V47, P794, DOI 10.1007/s00125-004-1391-x
   Rizvi AA, 2009, AM J MED SCI, V338, P310, DOI 10.1097/MAJ.0b013e3181a4158c
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Rossoni G, 2003, J PHARMACOL EXP THER, V307, P633, DOI 10.1124/jpet.103.054700
   Rossoni G, 1999, J CARDIOVASC PHARM, V34, P454, DOI 10.1097/00005344-199909000-00021
   Schmidt MI, 1999, LANCET, V353, P1649, DOI 10.1016/S0140-6736(99)01046-6
   Sen CK, 1996, BIOCHEM BIOPH RES CO, V218, P148, DOI 10.1006/bbrc.1996.0026
   Shields TM, 2004, ENDOCRIN METAB CLIN, V33, P577, DOI 10.1016/j.ecl.2004.03.015
   Sparatore A, 2009, FREE RADICAL BIO MED, V46, P586, DOI 10.1016/j.freeradbiomed.2008.11.013
   Stroff T, 1996, AM J PHYSIOL-GASTR L, V271, pG1017, DOI 10.1152/ajpgi.1996.271.6.G1017
   Varga O, 2010, OBES REV, V11, P792, DOI 10.1111/j.1467-789X.2009.00667.x
   Vaziri ND, 2000, HYPERTENSION, V36, P142, DOI 10.1161/01.HYP.36.1.142
NR 29
TC 46
Z9 54
U1 0
U2 13
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD DEC 1
PY 2010
VL 648
IS 1-3
BP 139
EP 145
DI 10.1016/j.ejphar.2010.08.039
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 673YV
UT WOS:000283701000019
PM 20826133
DA 2025-06-11
ER

PT J
AU Nielsen, FH
AF Nielsen, Forrest H.
TI Magnesium, inflammation, and obesity in chronic disease
SO NUTRITION REVIEWS
LA English
DT Review
DE chronic disease; inflammation; magnesium; obesity; oxidative stress
ID C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA; DIETARY MAGNESIUM; METABOLIC
   SYNDROME; ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; RECEPTOR
   BLOCKADE; OXIDATIVE STRESS; SERUM MAGNESIUM; TNF-ALPHA
AB About 60% of adults in the United States do not consume the estimated average requirement for magnesium, but widespread pathological conditions attributed to magnesium deficiency have not been reported. Nevertheless, low magnesium status has been associated with numerous pathological conditions characterized as having a chronic inflammatory stress component. In humans, deficient magnesium intakes are mostly marginal to moderate (approximately 50% to < 100% of the recommended dietary allowance). Animal experiments indicate that signs of marginal-to-moderate magnesium deficiency can be compensated or exacerbated by other factors influencing inflammatory and oxidative stress; recent studies suggest a similar happening in humans. This suggestion may have significance in obesity, which is characterized as having a chronic low-grade inflammation component and an increased incidence of a low magnesium status. Marginal-to-moderate magnesium deficiency through exacerbating chronic inflammatory stress may be contributing significantly to the occurrence of chronic diseases such as atherosclerosis, hypertension, osteoporosis, diabetes mellitus, and cancer.
C1 ARS, USDA, Grand Forks Human Nutr Res Ctr, Grand Forks, ND 58202 USA.
C3 United States Department of Agriculture (USDA)
RP Nielsen, FH (corresponding author), ARS, USDA, Grand Forks Human Nutr Res Ctr, 2420 2 Ave N Stop 9034, Grand Forks, ND 58202 USA.
EM forrest.nielsen@ars.usda.gov
CR Abbott RD, 2003, AM J CARDIOL, V92, P665, DOI [10.1016/S0002-9149(03)00819-1, 10.1016/s0002-9149(03)00819-1]
   Abrams SA, 1997, AM J CLIN NUTR, V66, P1172, DOI 10.1093/ajcn/66.5.1172
   Adrian M, 2008, J HYPERTENS, V26, P44, DOI 10.1097/HJH.0b013e3282f09f68
   Aeberli I, 2006, AM J CLIN NUTR, V84, P748, DOI 10.1093/ajcn/84.4.748
   Agus MSD, 2001, CRIT CARE CLIN, V17, P175, DOI 10.1016/S0749-0704(05)70158-5
   Alloui A, 2003, EUR J PHARMACOL, V469, P65, DOI 10.1016/S0014-2999(03)01719-9
   Almoznino-Sarafian D, 2007, EUR J NUTR, V46, P230, DOI 10.1007/s00394-007-0655-x
   [Anonymous], 1997, DIET REF INT CALC PH
   [Anonymous], 2004, Vitamin and Mineral Requirements in Human Nutrition, P217
   Arita Y, 1999, BIOCHEM BIOPH RES CO, V257, P79, DOI 10.1006/bbrc.1999.0255
   Atrakchi A H, 1992, Cardiovasc Pathol, V1, P155, DOI 10.1016/1054-8807(92)90019-K
   Barbagallo Mario, 2003, Molecular Aspects of Medicine, V24, P39, DOI 10.1016/S0098-2997(02)00090-0
   Bo S, 2006, AM J CLIN NUTR, V84, P1062, DOI 10.1093/ajcn/84.5.1062
   Bolland MJ, 2008, BMJ-BRIT MED J, V336, P262, DOI 10.1136/bmj.39440.525752.BE
   Bose M, 2008, J NUTR, V138, P1677, DOI 10.1093/jn/138.9.1677
   Bruton JD, 2002, PFLUG ARCH EUR J PHY, V444, P692, DOI 10.1007/s00424-002-0882-1
   Busserolles J, 2002, BRIT J NUTR, V87, P337, DOI 10.1079/BJNBJN2002524
   Busserolles J, 2003, MAGNESIUM RES, V16, P7
   Bussiere F., 2001, Advances in magnesium research: nutrition and health, P313
   CALDER PC, 2000, BR J NUTR S, V101, pS1
   Calder PC, 2006, AM J CLIN NUTR, V83, p1505S, DOI 10.1093/ajcn/83.6.1505S
   Canavan B, 2005, J CLIN ENDOCR METAB, V90, P5779, DOI 10.1210/jc.2005-0780
   Chacko SA, 2010, DIABETES CARE, V33, P304, DOI 10.2337/dc09-1402
   Chaudhary DP, 2007, EUR J NUTR, V46, P383, DOI 10.1007/s00394-007-0677-4
   Considine RV, 1996, NEW ENGL J MED, V334, P292, DOI 10.1056/NEJM199602013340503
   Corica F, 1999, AM J HYPERTENS, V12, P128, DOI 10.1016/S0895-7061(98)00174-5
   Corica F, 1997, AM J HYPERTENS, V10, P1311
   Corica F, 2006, J AM COLL NUTR, V25, P210, DOI 10.1080/07315724.2006.10719534
   Dai Q, 2007, AM J CLIN NUTR, V86, P743, DOI 10.1093/ajcn/86.3.743
   DeFuria J, 2009, J NUTR, V139, P1510, DOI 10.3945/jn.109.105155
   Dong F, 2006, J ENDOCRINOL, V188, P25, DOI 10.1677/joe.1.06241
   Durakoglugil M, 2005, J NEUROCHEM, V95, P396, DOI 10.1111/j.1471-4159.2005.03375.x
   Ford ES, 1999, DIABETES CARE, V22, P1971, DOI 10.2337/diacare.22.12.1971
   FREEDMAN AM, 1990, BIOCHEM BIOPH RES CO, V170, P1102, DOI 10.1016/0006-291X(90)90506-I
   Freedman AM, 1992, MAGNES TRACE ELEM, V10, P348
   García OP, 2009, NUTR REV, V67, P559, DOI 10.1111/j.1753-4887.2009.00228.x
   Guermouche B, 2004, OBES RES, V12, P1744, DOI 10.1038/oby.2004.216
   He K, 2006, CIRCULATION, V113, P1675, DOI 10.1161/CIRCULATIONAHA.105.588327
   HEGSTED DM, 1956, J NUTR, V58, P175
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   HOTAMISLIGIL GS, 1995, J CLIN INVEST, V95, P2409, DOI 10.1172/JCI117936
   Huerta MG, 2005, DIABETES CARE, V28, P1175, DOI 10.2337/diacare.28.5.1175
   King DE, 2007, MAGNESIUM RES, V20, P32
   King DE, 2006, NUTR RES, V26, P193, DOI 10.1016/j.nutres.2006.05.001
   King DE, 2005, J AM COLL NUTR, V24, P166, DOI 10.1080/07315724.2005.10719461
   Kramer JH, 2003, EXP BIOL MED, V228, P665, DOI 10.1177/153537020322800604
   Kruse HD, 1932, J BIOL CHEM, V96, P519
   Latham JR, 2009, DIABETES, V58, P2656, DOI 10.2337/db08-1763
   Lee O, 2009, CHEM-BIOL INTERACT, V178, P332, DOI 10.1016/j.cbi.2008.10.011
   Lee S, 2009, NUTR METAB CARDIOVAS, V19, P781, DOI 10.1016/j.numecd.2009.01.002
   Leone N, 2006, EPIDEMIOLOGY, V17, P308, DOI 10.1097/01.ede.0000209454.41466.b7
   Libby P, 2007, NUTR REV, V65, pS140, DOI 10.1301/nr.2007.dec.S140-S146
   Lima-Leopoldo AP, 2008, BRAZ J MED BIOL RES, V41, P615, DOI 10.1590/S0100-879X2008000700011
   Lukaski HC, 2002, J NUTR, V132, P930, DOI 10.1093/jn/132.5.930
   MA J, 1995, J CLIN EPIDEMIOL, V48, P927, DOI 10.1016/0895-4356(94)00200-A
   Mak IT, 2003, MAGNESIUM RES, V16, P91
   Mazur A, 2007, ARCH BIOCHEM BIOPHYS, V458, P48, DOI 10.1016/j.abb.2006.03.031
   Moshfegh A., 2009, What We Eat in America, NHANES 2005-2006: Usual Nutrient Intakes from Food and Water Compared to 1997 Dietary Reference Intakes for Vitamin D, Calcium, Phosphorus, and Magnesium
   Nakata M, 2005, DIABETES RES CLIN PR, V70, P209, DOI 10.1016/j.diabres.2005.03.036
   Nielsen FH, 2007, MAGNESIUM RES, V20, P19
   Ouchi N, 2000, CIRCULATION, V102, P1296, DOI 10.1161/01.CIR.102.11.1296
   PLANELLS E, 1993, NUTR RES, V13, P691, DOI 10.1016/S0271-5317(05)80561-5
   Pradhan A, 2007, NUTR REV, V65, pS152, DOI 10.1301/nr.2007.dec.S152-S156
   Rayssiguier Y, 2006, MAGNESIUM RES, V19, P237
   Ridker PM, 2007, NUTR REV, V65, pS253, DOI 10.1301/nr.2007.dec.S253-S259
   ROBINSON LE, 2007, APPL PHYSIOL NUTR ME, V32, P1998
   Rodríguez-Morán M, 2008, ARCH DIS CHILD, V93, P676, DOI 10.1136/adc.2006.109371
   Rodríguez-Morán M, 2004, MAGNESIUM RES, V17, P189
   Rude RK, 2009, GROWTH FACTORS, V27, P370, DOI 10.3109/08977190903152644
   Rude RK, 2009, J AM COLL NUTR, V28, P131, DOI 10.1080/07315724.2009.10719764
   Schmitz C, 2003, CELL, V114, P191, DOI 10.1016/S0092-8674(03)00556-7
   Seymour EM, 2009, J MED FOOD, V12, P935, DOI 10.1089/jmf.2008.0270
   Sohet FM, 2009, BIOCHEM PHARMACOL, V78, P1391, DOI 10.1016/j.bcp.2009.07.008
   Song YQ, 2007, AM J CLIN NUTR, V85, P1068, DOI 10.1093/ajcn/85.4.1068
   Sun XC, 2007, OBESITY, V15, P1944, DOI 10.1038/oby.2007.232
   Tejero-Taldo MI, 2006, HEART FAIL REV, V11, P35, DOI 10.1007/s10741-006-9191-7
   Tejero-Taldo MI, 2004, J PHARMACOL EXP THER, V311, P8, DOI 10.1124/jpet.104.070003
   Terra X, 2009, J NUTR BIOCHEM, V20, P210, DOI 10.1016/j.jnutbio.2008.02.005
   Touyz R. M., 2003, Molecular Aspects of Medicine, V24, P107, DOI 10.1016/S0098-2997(02)00094-8
   Vormann J, 1998, Z ERNAHRUNGSWISS, V37, P92
   Weglicki W B, 1992, Am J Cardiovasc Pathol, V4, P210
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Xue BZ, 1998, FASEB J, V12, P1391, DOI 10.1096/fasebj.12.13.1391
   Xue BZ, 1999, PHYSIOL GENOMICS, V1, P11, DOI 10.1152/physiolgenomics.1999.1.1.11
   ZEMEL MB, 1990, METABOLISM, V39, P704, DOI 10.1016/0026-0495(90)90104-K
NR 88
TC 209
Z9 232
U1 1
U2 29
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD JUN
PY 2010
VL 68
IS 6
BP 333
EP 340
DI 10.1111/j.1753-4887.2010.00293.x
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 603GJ
UT WOS:000278196400002
PM 20536778
DA 2025-06-11
ER

PT J
AU Misiak, B
   Kowalski, K
   Stanczykiewicz, B
   Bartoli, F
   Carrà, G
   Samochowiec, J
   Samochowiec, A
   Frydecka, D
AF Misiak, Blazej
   Kowalski, Krzysztof
   Stanczykiewicz, Bartlomiej
   Bartoli, Francesco
   Carra, Giuseppe
   Samochowiec, Jerzy
   Samochowiec, Agnieszka
   Frydecka, Dorota
TI Appetite-regulating hormones in bipolar disorder: A systematic review
   and meta-analysis
SO FRONTIERS IN NEUROENDOCRINOLOGY
LA English
DT Review
DE Mood disorder; Depression; Adiposity; Obesity; Overweight
ID DRUG-NAIVE PATIENTS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   PROINFLAMMATORY MARKERS; INFLAMMATORY MARKERS; NEUROTROPHIC FACTOR;
   LEPTIN; ADIPONECTIN; DEPRESSION; DYSFUNCTION
AB Impaired hormonal regulation of appetite may contribute to higher cardiovascular risk in bipolar disorder (BD). We performed a systematic review and meta-analysis of studies investigating peripheral blood levels of appetiteregulating hormones in BD and controls. A total of 32 studies were included. Leptin and insulin levels were significantly elevated in patients with BD during euthymia, but not in other mood states. Greater differences in the number of male participants between patients with BD and healthy controls were associated with higher effect size estimates for the levels of insulin. There were significant positive correlations of effect size estimates for the levels of adiponectin with the percentage of individuals with type I BD and duration of BD. Our findings point to the mechanisms underlying high rates of cardiometabolic comorbidities in BD. Moreover, they suggest that investigating hormonal regulation of appetite might help to understand differences in the neurobiology of BD types.
C1 [Misiak, Blazej; Kowalski, Krzysztof; Stanczykiewicz, Bartlomiej] Wroclaw Med Univ, Dept Psychiat, Div Consultat Psychiat & Neurosci, Pasteura 10 St, PL-50367 Wroclaw, Poland.
   [Bartoli, Francesco; Carra, Giuseppe] Univ Milano Bicocca, Dept Med & Surg, Piazza Ateneo Nuovo 1, I-20126 Monza, Italy.
   [Bartoli, Francesco; Carra, Giuseppe] ASST Nord Milano, Dept Mental Hlth & Addict, Viale Matteotti 83, I-20099 Milan, Italy.
   [Carra, Giuseppe] UCL, Div Psychiat, 149 Tottenham Court Rd, London W1T 7NF, England.
   [Samochowiec, Jerzy] Pomeranian Med Univ, Dept Psychiat, Broniewskiego 26 St, PL-71460 Szczecin, Poland.
   [Samochowiec, Agnieszka] Univ Szczecin, Inst Psychol, Dept Clin Psychol, Krakowska 69 St, PL-71017 Szczecin, Poland.
   [Frydecka, Dorota] Wroclaw Med Univ, Dept & Clin Psychiat, Pasteura 10 St, PL-50367 Wroclaw, Poland.
C3 Wroclaw Medical University; University of Milano-Bicocca; University of
   London; University College London; Pomeranian Medical University;
   University of Szczecin; Wroclaw Medical University
RP Misiak, B (corresponding author), Wroclaw Med Univ, Dept Psychiat, Div Consultat Psychiat & Neurosci, Pasteura 10 St, PL-50367 Wroclaw, Poland.
EM blazej.misiak@umed.wroc.pl
RI Frydecka, Dorota/ABD-8176-2021; Kowalski, Krzysztof/GZG-2552-2022;
   Samochowiec, Jerzy/G-8175-2014; Misiak, Błażej/ABA-2657-2021;
   Stanczykiewicz, Bartlomiej/J-5742-2017; Kowalski,
   Krzysztof/GXH-9273-2022; Carra, Giuseppe/C-6091-2012; Bartoli,
   Francesco/K-5755-2016
OI Stanczykiewicz, Bartlomiej/0000-0001-9221-3502; Kowalski,
   Krzysztof/0000-0002-7145-8284; Carra, Giuseppe/0000-0002-6877-6169;
   /0000-0001-9783-7234; Frydecka, Dorota/0000-0001-8582-9958; Bartoli,
   Francesco/0000-0003-2612-4119; Misiak, Blazej/0000-0002-5392-6398
CR Atkinson TJ, 2008, OBES REV, V9, P108, DOI 10.1111/j.1467-789X.2007.00412.x
   Bahji A, 2021, CAN J PSYCHIAT, V66, P274, DOI 10.1177/0706743720970857
   Bai YM, 2014, J AFFECT DISORDERS, V166, P187, DOI 10.1016/j.jad.2014.05.009
   Barbosa IG, 2012, J PSYCHIATR RES, V46, P389, DOI 10.1016/j.jpsychires.2011.11.010
   Bartoli F, 2013, AM J PSYCHIAT, V170, P927, DOI 10.1176/appi.ajp.2013.13040447
   Belmaker RH, 2004, NEW ENGL J MED, V351, P476, DOI 10.1056/NEJMra035354
   Blázquez E, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00161
   Bond DJ, 2017, J CLIN PSYCHIAT, V78, P441, DOI 10.4088/JCP.15m10189
   Bora E, 2019, PSYCHOL MED, V49, P738, DOI 10.1017/S0033291718003008
   Cairns K, 2018, J PSYCHIATR RES, V102, P34, DOI 10.1016/j.jpsychires.2018.03.006
   Calkin C, 2009, BIPOLAR DISORD, V11, P650, DOI 10.1111/j.1399-5618.2009.00730.x
   Calkin CV, 2019, ANN MED, V51, P281, DOI 10.1080/07853890.2019.1659511
   Chang HH, 2022, CNS SPECTRUMS, V27, P598, DOI 10.1017/S1092852921000158
   Charles EF, 2016, INT J BIPOLAR DISORD, V4, DOI 10.1186/s40345-016-0054-4
   Chen L, 2012, NAT REV ENDOCRINOL, V8, P228, DOI 10.1038/nrendo.2011.183
   Chen MH, 2021, WORLD J BIOL PSYCHIA, V22, P428, DOI 10.1080/15622975.2020.1819566
   Cicero AFG, 2011, INT J ENDOCRINOL, V2011, DOI 10.1155/2011/724816
   Coello K, 2019, INT J BIPOLAR DISORD, V7, DOI 10.1186/s40345-019-0142-3
   Cordas G, 2015, NEUROENDOCRINOLOGY, V101, P82, DOI 10.1159/000371803
   Cumpston MS, Cochrane Handbook for Systematic Reviews of Interventions Version 6.0
   da Silva EG, 2017, PSYCHIAT RES, V250, P30, DOI 10.1016/j.psychres.2017.01.061
   Depp CA, 2014, BIPOLAR DISORD, V16, P422, DOI 10.1111/bdi.12200
   Dmitrzak-Weglarz M, 2021, WORLD J BIOL PSYCHIA, V22, P744, DOI 10.1080/15622975.2021.1907715
   Dolab N, 2020, HELIYON, V6, DOI 10.1016/j.heliyon.2020.e04553
   Dolapoglu N, 2021, NOROPSIKIYATRI ARS, V58, P16, DOI 10.29399/npa.25005
   Elmslie JL, 2009, AUST NZ J PSYCHIAT, V43, P53, DOI 10.1080/00048670802534341
   Fe RW, 2011, J CLIN EPIDEMIOL, V64, P1187, DOI 10.1016/j.jclinepi.2010.08.010
   Fernandes BS, 2016, EUR PSYCHIAT, V35, P1, DOI 10.1016/j.eurpsy.2016.02.003
   Fleet-Michaliszyn SB, 2008, J CLIN PSYCHIAT, V69, P1892, DOI 10.4088/JCP.v69n1207
   Fornaro M, 2021, J AFFECT DISORDERS, V280, P409, DOI 10.1016/j.jad.2020.11.015
   Geijselaers SLC, 2017, DIABETES CARE, V40, P1537, DOI 10.2337/dc17-0330
   Gergerlioglu HS, 2006, NEUROPSYCHOBIOLOGY, V53, P108, DOI 10.1159/000092219
   Gomez-Arango LF, 2018, GUT MICROBES, V9, P189, DOI 10.1080/19490976.2017.1406584
   Gray SM, 2014, DIABETES, V63, P3992, DOI 10.2337/db14-0340
   Gröschl M, 2000, HORM RES, V54, P26, DOI 10.1159/000063433
   Guha P, 2014, INDIAN J CLIN BIOCHE, V29, P51, DOI 10.1007/s12291-012-0292-x
   Higgins J, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.ED000049
   Hoehn KL, 2009, P NATL ACAD SCI USA, V106, P17787, DOI 10.1073/pnas.0902380106
   Hommel JD, 2006, NEURON, V51, P801, DOI 10.1016/j.neuron.2006.08.023
   Hozo SP., 2005, BMC MED RES METHODOL, V5, DOI [10.1186/1471-2288-5-13, DOI 10.1186/1471-2288-5-13]
   Huang KL, 2022, CNS SPECTRUMS, V27, P450, DOI 10.1017/S109285292100016X
   Hung YJ, 2007, CLIN ENDOCRINOL, V67, P784, DOI 10.1111/j.1365-2265.2007.02963.x
   IntHout J, 2014, BMC MED RES METHODOL, V14, DOI 10.1186/1471-2288-14-25
   Juster RP, 2018, J PSYCHOSOM RES, V115, P101, DOI 10.1016/j.jpsychores.2018.10.012
   Karanti A, 2020, BIPOLAR DISORD, V22, P392, DOI 10.1111/bdi.12867
   Kauer-Sant'Anna M, 2009, INT J NEUROPSYCHOPH, V12, P447, DOI 10.1017/S1461145708009310
   Kemp DE, 2010, BIPOLAR DISORD, V12, P404, DOI 10.1111/j.1399-5618.2010.00823.x
   Kieffer TJ, 2000, AM J PHYSIOL-ENDOC M, V278, pE1, DOI 10.1152/ajpendo.2000.278.1.E1
   Kizer JR, 2012, CIRCULATION, V126, P2951, DOI 10.1161/CIRCULATIONAHA.112.135202
   Langan D, 2019, RES SYNTH METHODS, V10, P83, DOI 10.1002/jrsm.1316
   Lee HJ, 2014, NEUROPSYCHOBIOLOGY, V70, P203, DOI 10.1159/000366488
   Lindmark S, 2006, CLIN ENDOCRINOL, V65, P301, DOI 10.1111/j.1365-2265.2006.02593.x
   Liu YK, 2022, J AFFECT DISORDERS, V300, P449, DOI 10.1016/j.jad.2021.12.110
   Maina G, 2008, J AFFECT DISORDERS, V110, P149, DOI 10.1016/j.jad.2007.12.233
   Maletic V, 2014, FRONT PSYCHIATRY, V5, DOI 10.3389/fpsyt.2014.00098
   Mansur RB, 2020, BIPOLAR DISORD, V22, P79, DOI 10.1111/bdi.12826
   Mansur RB, 2016, J PSYCHIATR RES, V74, P63, DOI 10.1016/j.jpsychires.2015.12.003
   Mazereel V, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.573479
   McElroy S.L., 2002, PRIM CARE COMPANION
   McGuinness AJ, 2022, MOL PSYCHIATR, V27, P1920, DOI 10.1038/s41380-022-01456-3
   McIntyre RS, 2021, NUTR NEUROSCI, V24, P173, DOI 10.1080/1028415X.2019.1612555
   McIntyre RS, 2010, J AFFECT DISORDERS, V126, P366, DOI 10.1016/j.jad.2010.04.012
   Misiak B, 2020, BRAIN BEHAV IMMUN, V88, P870, DOI 10.1016/j.bbi.2020.04.013
   Misiak B, 2019, PSYCHONEUROENDOCRINO, V104, P74, DOI 10.1016/j.psyneuen.2019.02.019
   Munkholm K, 2013, J PSYCHIATR RES, V47, P1119, DOI 10.1016/j.jpsychires.2013.05.018
   Murri MB, 2016, PSYCHONEUROENDOCRINO, V63, P327, DOI 10.1016/j.psyneuen.2015.10.014
   Nolan CJ, 2015, DIABETES, V64, P673, DOI 10.2337/db14-0694
   Nordström A, 2016, J CLIN ENDOCR METAB, V101, P3740, DOI 10.1210/jc.2016-1915
   Page M.J., [No title captured]
   Parlak N, 2018, PSYCHIAT RES, V260, P36, DOI 10.1016/j.psychres.2017.11.018
   Paz-Filho Gilberto, 2012, Indian J Endocrinol Metab, V16, pS549, DOI 10.4103/2230-8210.105571
   Platzer M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010076
   Platzer M, 2019, WORLD J BIOL PSYCHIA, V20, P813, DOI 10.1080/15622975.2018.1500033
   Rasgon NL, 2010, BIPOLAR DISORD, V12, P504, DOI 10.1111/j.1399-5618.2010.00839.x
   Rosso G, 2015, J AFFECT DISORDERS, V184, P293, DOI 10.1016/j.jad.2015.06.006
   Roubos EW, 2012, GEN COMP ENDOCR, V177, P28, DOI 10.1016/j.ygcen.2012.01.009
   Sattar N, 2006, CIRCULATION, V114, P623, DOI 10.1161/CIRCULATIONAHA.106.618918
   Scaini G, 2016, NEUROSCI BIOBEHAV R, V68, P694, DOI 10.1016/j.neubiorev.2016.06.040
   Shea SA, 2005, J CLIN ENDOCR METAB, V90, P2537, DOI 10.1210/jc.2004-2232
   Soczynska JK, 2011, NEUROMOL MED, V13, P93, DOI 10.1007/s12017-010-8140-8
   Soeiro-de-Souza MG, 2014, NEUROSCI LETT, V564, P111, DOI 10.1016/j.neulet.2014.02.005
   Sterne J.A.C., 2008, Cochrane handbook for systematic reviews of interventions: Cochrane book series
   Su SC, 2011, INT J PSYCHIAT MED, V42, P211, DOI 10.2190/PM.42.3.a
   Syk M, 2019, PSYCHIAT RES, V272, P1, DOI 10.1016/j.psychres.2018.11.075
   Tang BL, 2008, BIOCHEM BIOPH RES CO, V368, P181, DOI 10.1016/j.bbrc.2008.01.063
   Tramunt B, 2020, DIABETOLOGIA, V63, P453, DOI 10.1007/s00125-019-05040-3
   Tsai SY, 2014, BIPOLAR DISORD, V16, P800, DOI 10.1111/bdi.12240
   Tsai SY, 2012, J AFFECT DISORDERS, V136, P110, DOI 10.1016/j.jad.2011.08.022
   Tufanaru C, 2015, INT J EVID-BASED HEA, V13, P196, DOI 10.1097/XEB.0000000000000065
   Tunçel ÖK, 2018, NORD J PSYCHIAT, V72, P150, DOI 10.1080/08039488.2017.1402953
   Vargas HO, 2014, LIFE SCI, V102, P65, DOI 10.1016/j.lfs.2014.02.033
   Venkatasubramanian G, 2010, CLIN NEUROPHARMACOL, V33, P288, DOI 10.1097/WNF.0b013e3181fa2a6f
   Vianna-Sulzbach M, 2015, PSYCHIAT RES, V230, P719, DOI 10.1016/j.psychres.2015.09.040
   Wang TY, 2016, INT J NEUROPSYCHOPH, V19, DOI 10.1093/ijnp/pyw012
   Wei YG, 2020, TRANSL PSYCHIAT, V10, DOI 10.1038/s41398-020-00932-0
   Wendt Frank R, 2020, Chronic Stress (Thousand Oaks), V4, p2470547020924844, DOI 10.1177/2470547020924844
   Williams RL, 2016, APPETITE, V101, P1, DOI 10.1016/j.appet.2016.02.153
   Yim CY, 2012, EUR PSYCHIAT, V27, P223, DOI 10.1016/j.eurpsy.2011.02.004
   Yu JH, 2012, DIABETES METAB J, V36, P391, DOI 10.4093/dmj.2012.36.6.391
NR 99
TC 9
Z9 9
U1 1
U2 33
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-3022
EI 1095-6808
J9 FRONT NEUROENDOCRIN
JI Front. Neuroendocrinol.
PD OCT
PY 2022
VL 67
AR 101013
DI 10.1016/j.yfrne.2022.101013
EA JUL 2022
PG 10
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 4Y7UR
UT WOS:000861729400001
PM 35792198
OA hybrid
DA 2025-06-11
ER

PT J
AU Nie, YW
   Wang, CC
   Yang, L
   Yang, Z
   Sun, YH
   Tian, MZ
   Ma, YH
   Zhang, YX
   Yuan, YM
   Zhang, LP
AF Nie, Yanwu
   Wang, Chenchen
   Yang, Lei
   Yang, Zhen
   Sun, Yahong
   Tian, Maozai
   Ma, Yuhua
   Zhang, Yuxia
   Yuan, Yimu
   Zhang, Liping
TI Relationship Analysis of Inorganic Arsenic Exposure and Metabolic
   Syndrome Based on Propensity Score Matching in Xinjiang, China
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE metabolic syndrome; urinary inorganic arsenic; propensity score
   matching; subgroup analysis
ID OXIDATIVE STRESS; HEAVY-METALS; ADULTS; PREVALENCE; ASSOCIATION;
   METHYLATION; DISEASE; MICE
AB Purpose: The role of inorganic arsenic (iAs) in the risk of metabolic syndrome (MetS) remains unclear. This investigation focused on the effect of iAs exposure on MetS and whether the results are consistent in different subgroups. Patients and Methods: The present study was conducted on 629 men and 616 women aged 35-70 years and living in Xinjiang Uygur Autonomous Region, China. The 1:1 propensity score matching (PSM) was adopted to regulate the confounding factors, and the multivariate logistic regression was performed to assess the relationship between urinary iAs and MetS. Results: The median content of urinary iAs was examined as 2.20 mu g/dL (interquartile range: 1.30-3.20 mu g/dL), and the MetS prevalence reached 23.69% (295 cases/950 participants). After the confounding factors were adjusted, the ORs (95% CIs) for MetS from the minimal to the maximum urinary iAs quartiles reached 1.171 (0.736,1.863), 1.568 (1.008, 2.440) and 2.011 (1.296, 3.120), respectively (referencing 1.00) (P for trend=0.001). After the PSM, the urinary iAs content still plays a potential prediction role in MetS (P for trend=0.011). In addition, as revealed from the subgroup analysis, the urinary iAs content was a predictor of MetS in the female patients, whereas it did not serve as a significant predictor of MetS in the male patients (P for interaction<0.05). Conclusion: The increased urinary iAs content was associated with the increased prevalence of MetS in Chinese population. More attention should be paid to female urinary iAs content to avoid the high prevalence of MetS.
C1 [Nie, Yanwu] Xinjiang Med Univ, Sch Publ Hlth, State Key Lab Pathogenesis Prevent & Treatment Hi, Urumqi 830017, Peoples R China.
   [Wang, Chenchen] Ctr Dis Control & Prevent Xinjiang Uygur Autonomo, Urumqi 830017, Peoples R China.
   [Yang, Lei] Xinjiang Med Univ, Sch Nursing, Urumqi 830017, Peoples R China.
   [Yang, Zhen; Sun, Yahong] Xinjiang Med Univ, Sch Publ Hlth, Urumqi 830017, Peoples R China.
   [Tian, Maozai] Renmin Univ China, Ctr Appl Stat, Sch Stat, Beijing 100872, Peoples R China.
   [Tian, Maozai; Zhang, Liping] Xinjiang Med Univ, Coll Med Engn & Technol, Urumqi 830017, Peoples R China.
   [Ma, Yuhua] Tongji Univ, Shanghai East Hosp, Dept Oncol, Sch Med, Shanghai 200120, Peoples R China.
   [Ma, Yuhua] Karamay Cent Hosp XinJiang Karamay, Dept Pathol, Karamay 834000, Xinjiang Uygur, Peoples R China.
   [Zhang, Yuxia] Urumqi Maternal & Child Hlth Inst, Dept Clin Nutr, Urumqi 830001, Peoples R China.
   [Yuan, Yimu] Xinjiang Corps Hosp, Dept Gen Practice Med, Urumqi, Peoples R China.
C3 Xinjiang Medical University; Xinjiang Medical University; Xinjiang
   Medical University; Renmin University of China; Xinjiang Medical
   University; Tongji University
RP Zhang, LP (corresponding author), Xinjiang Med Univ, Coll Med Engn & Technol, Urumqi 830017, Peoples R China.
EM zhanglp1219@163.com
RI Wang, Hengliang/AAT-4586-2021
FU State Key Laboratory of Pathogenesis, Prevention and Treatment of High
   Incidence Diseases in Central Asia Fund [SKL-HIDCA-2020-9]; National
   Natural Science Foundation of China [72163033, 72064036, 72174175];
   Natural science funding of Xinjiang Uygur Autonomous Region, China
   [2021D01A21]
FX This work was funded by State Key Laboratory of Pathogenesis, Prevention
   and Treatment of High Incidence Diseases in Central Asia Fund
   (SKL-HIDCA-2020-9) , National Natural Science Foundation of China
   (GrantNo. 72163033, 72064036, 72174175) and the Natural science funding
   of Xinjiang Uygur Autonomous Region (2021D01A21) , China.
CR Abuawad A, 2021, ENVIRON INT, V149, DOI 10.1016/j.envint.2021.106401
   Agusa T, 2011, INT J MOL SCI, V12, P2351, DOI 10.3390/ijms12042351
   Andreeva-Gateva P, 2001, Vutr Boles, V33, P48
   Austin PC, 2011, PHARM STAT, V10, P150, DOI 10.1002/pst.433
   Barchowsky A, 1996, FREE RADICAL BIO MED, V21, P783, DOI 10.1016/0891-5849(96)00174-8
   Bryan MS, 2019, INT J EPIDEMIOL, V48, P876, DOI 10.1093/ije/dyz046
   Bulka CM, 2019, ENVIRON RES, V168, P397, DOI 10.1016/j.envres.2018.10.022
   Chiou HY, 1997, STROKE, V28, P1717, DOI 10.1161/01.STR.28.9.1717
   De Anda V, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-22736-6
   Gao JW, 2011, INT J ENV RES PUB HE, V8, P1991, DOI 10.3390/ijerph8061991
   Garbinski LD, 2019, ENVIRON INT, V126, P585, DOI 10.1016/j.envint.2019.02.058
   González-Domínguez A, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21155529
   Hall EM, 2017, ENVIRON RES, V153, P99, DOI 10.1016/j.envres.2016.11.016
   He J., 2014, RES PREVALENCE CHARA
   HopenhaynRich C, 1996, ENVIRON HEALTH PERSP, V104, P1200, DOI 10.2307/3432913
   Hopps E, 2010, NUTR METAB CARDIOVAS, V20, P72, DOI 10.1016/j.numecd.2009.06.002
   Huang CF, 2015, ENVIRON HEALTH PERSP, V123, P1138, DOI 10.1289/ehp.1408663
   Huang M, 2021, ECOTOX ENVIRON SAFE, V208, DOI 10.1016/j.ecoenv.2020.111435
   Huang SL, 2022, ECOTOX ENVIRON SAFE, V231, DOI 10.1016/j.ecoenv.2022.113183
   Jiang BR, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0747-z
   Kao TW, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22136862
   Karn SK, 2015, ENVIRON POLLUT, V207, P434, DOI 10.1016/j.envpol.2015.05.005
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Kazemifar Amir Mohammad, 2020, Environ Anal Health Toxicol, V35, pe2020006, DOI 10.5620/eaht.e2020006
   Kile ML, 2008, NUTR REV, V66, P349, DOI 10.1111/j.1753-4887.2008.00043.x
   Kolb H, 2017, BMC MED, V15, DOI 10.1186/s12916-017-0901-x
   Lee MK, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-59203-z
   Li CH, 2012, CHIN J PREVENT MED, V5, P419
   Li X, 2013, ENVIRON HEALTH-GLOB, V12, DOI 10.1186/1476-069X-12-37
   Liu TY, 2015, CLIN SCI, V129, P839, DOI 10.1042/CS20150009
   Fujita ATL, 2021, J BRAS PNEUMOL, V47, DOI 10.36416/1806-3756/e20210050
   López-Carrillo L, 2016, ENVIRON RES, V151, P445, DOI 10.1016/j.envres.2016.08.015
   Lu JL, 2017, J CLIN ENDOCR METAB, V102, P507, DOI 10.1210/jc.2016-2477
   Min J, 2021, DIABET METAB SYND OB, V14, P2561, DOI 10.2147/DMSO.S313475
   Mittendorfer B, 2001, AM J CLIN NUTR, V73, P892
   Pace C, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15010168
   Pace C, 2016, TOXICOL IN VITRO, V35, P188, DOI 10.1016/j.tiv.2016.06.006
   Pi JB, 2002, ENVIRON HEALTH PERSP, V110, P331, DOI 10.1289/ehp.02110331
   Muñoz MP, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15071418
   Roberts CK, 2006, METABOLISM, V55, P928, DOI 10.1016/j.metabol.2006.02.022
   Rotter I, 2015, INT J ENV RES PUB HE, V12, P3944, DOI 10.3390/ijerph120403944
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sarker A, 2022, ENVIRON SCI POLLUT R, V29, P3230, DOI 10.1007/s11356-021-17153-7
   Sharifpour P, 2020, DIABET METAB SYND OB, V13, P2251, DOI 10.2147/DMSO.S260677
   Shin S, 2020, J EXERC REHABIL, V16, P27, DOI 10.12965/jer.1938758.379
   Shiue I, 2017, ENVIRON SCI POLLUT R, V24, P3108, DOI 10.1007/s11356-016-8054-6
   Song XB, 2017, BIOL TRACE ELEM RES, V179, P140, DOI 10.1007/s12011-017-0950-1
   Spratlen MJ, 2018, AM J EPIDEMIOL, V187, P1598, DOI 10.1093/aje/kwy048
   Sun GF, 2006, J HEALTH POPUL NUTR, V24, P176
   Thomas ML, 2018, CANCERS, V10, DOI 10.3390/cancers10040101
   Wang WJ, 2014, J EPIDEMIOL COMMUN H, V68, P176, DOI 10.1136/jech-2013-203114
   Wilsnack RW, 2018, ALCOHOL RES-CURR REV, V39, P57
   Xiong Y, 2021, TRANSL ANDROL UROL, V10, DOI 10.21037/tau-20-1127
   Xu LQ, 2021, ENVIRON GEOCHEM HLTH, V43, P2505, DOI 10.1007/s10653-020-00573-8
   Ye RS, 2013, MOL METAB, V2, P133, DOI 10.1016/j.molmet.2013.04.001
NR 55
TC 3
Z9 3
U1 0
U2 18
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2022
VL 15
BP 921
EP 931
DI 10.2147/DMSO.S349583
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 0G9QA
UT WOS:000778373900004
PM 35370411
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Vasmehjani, AA
   Darabi, Z
   Nadjarzadeh, A
   Mirzaei, M
   Hosseinzadeh, M
AF Vasmehjani, Azam Ahmadi
   Darabi, Zahra
   Nadjarzadeh, Azadeh
   Mirzaei, Masoud
   Hosseinzadeh, Mahdieh
TI The relation between dietary phytochemical index and metabolic syndrome
   and its components in a large sample of Iranian adults: a
   population-based study
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Dietary phytochemical index; Metabolic syndrome; Phytochemical-rich
   foods; Triglyceride; Hypertension; Iran
ID 3-YEAR FOLLOW-UP; OXIDATIVE STRESS; BLOOD-PRESSURE; ATHEROSCLEROSIS
   RISK; INSULIN-RESISTANCE; KOREAN WOMEN; VITAMIN-C; HYPERTENSION; FRUIT;
   ASSOCIATION
AB Background Despite the protective effects of foods being rich in phytochemicals against chronic diseases, this issue is still poorly understood. The aim of this study was to investigate the association between Dietary Phytochemical Index (DPI) and metabolic syndrome (MetS) and its components. Methods This cross-sectional study focused on adults aged between 20 and 70years. The dietary intake was assessed using a validated and reliable food frequency questionnaire. DPI was calculated based on dietary energy, derived from phytochemical-rich food sources (kcal) per total daily energy intake (kcal). The odds ratio of MetS and its components were assessed across DPI quartiles by logistic regression models. Results After adjustment for all potential confounders, the risk of MetS (OR: 0.63, 95% CI = 0.41-0.96) and elevated blood pressure (OR: 0.62, 95% CI = 0.40-0.96) in the second category of DPI decreased significantly as compared to that in the first category. Subjects in the second and fourth quartiles of DPI with adjusting for age, sex and total energy intake revealed 30 and 25% lower risk of abdominal obesity, respectively. After full adjustment for confounders, the analysis stratified by sex showed women in the highest quartile of DPI had 59% lower risk of MetS (OR: 0.41, 95% CI = 0.22-0.76) as compared to those in the lowest quartile of DPI. Conclusions Greater adherence to phytochemical-rich diet could reduce odds of MetS and some components, especially in women. Further studies with intervention approaches are recommended.
C1 [Vasmehjani, Azam Ahmadi; Darabi, Zahra; Nadjarzadeh, Azadeh; Hosseinzadeh, Mahdieh] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Nutr & Food Secur Res Ctr, Yazd, Iran.
   [Vasmehjani, Azam Ahmadi; Darabi, Zahra; Nadjarzadeh, Azadeh; Hosseinzadeh, Mahdieh] Shahid Sadughi Univ Med Sci, Dept Nutr, Sch Publ Hlth, Yazd, Iran.
   [Mirzaei, Masoud] Shahid Sadoughi Univ Med Sci, Yazd Cardiovasc Res Ctr, Yazd, Iran.
C3 Shahid Sadoughi University of Medical Sciences; Shahid Sadoughi
   University of Medical Sciences
RP Hosseinzadeh, M (corresponding author), Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Nutr & Food Secur Res Ctr, Yazd, Iran.; Hosseinzadeh, M (corresponding author), Shahid Sadughi Univ Med Sci, Dept Nutr, Sch Publ Hlth, Yazd, Iran.
EM hoseinzade.mahdie@gmail.com
RI Mirzaei, Masoud/JVM-7958-2024; Nadjarzadeh, Azadeh/A-8490-2017
OI Mirzaei, Masoud/0000-0001-6455-0747
FU Nutrition and Food Security Research Center, Shahid Sadoughi University
   of Medical Sciences, Yazd, Iran
FX This research was funded by Nutrition and Food Security Research Center,
   Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
CR Abshirini M, 2018, INT J PREVENTIVE MED, V9, DOI 10.4103/ijpvm.IJPVM_145_18
   Bahadoran Z, 2013, J HUM NUTR DIET, V26, P145, DOI 10.1111/jhn.12048
   Bahadoran Z., 2012, IRANIAN J ENDOCRINOL, V14, P343
   Bahadoran Z, 2015, INT J FOOD SCI NUTR, V66, P950, DOI 10.3109/09637486.2015.1111867
   Bahadoran Z, 2013, ASIAN PAC J CANCER P, V14, P2747, DOI 10.7314/APJCP.2013.14.5.2747
   Dehghani Firouzabadi Fatemeh, 2021, Clin Nutr Res, V10, P161, DOI 10.7762/cnr.2021.10.2.161
   Djoussé L, 2009, CLIN NUTR, V28, P10, DOI 10.1016/j.clnu.2008.08.005
   Esfahani FH, 2010, J EPIDEMIOL, V20, P150, DOI 10.2188/jea.JE20090083
   Esmaillzadeh A, 2006, AM J CLIN NUTR, V84, P1489, DOI 10.1093/ajcn/84.6.1489
   Farhangi MA, 2017, BMC CARDIOVASC DISOR, V17, DOI 10.1186/s12872-017-0544-z
   Feldeisen SE, 2007, APPL PHYSIOL NUTR ME, V32, P46, DOI 10.1139/h06-101
   Flint AJ, 2009, AM J CLIN NUTR, V90, P493, DOI 10.3945/ajcn.2009.27460
   Castanho GKF, 2013, CIENC SAUDE COLETIVA, V18, P385, DOI 10.1590/S1413-81232013000200010
   Ghafarpour A., 1999, TEHRAN NASHRE OLUME, V4, P42
   Golzarand M, 2015, EUR J CLIN NUTR, V69, P392, DOI 10.1038/ejcn.2014.233
   Golzarand M, 2014, ARYA ATHEROSCLER, V10, P203
   Hanhineva K, 2010, INT J MOL SCI, V11, P1365, DOI 10.3390/ijms11041365
   Hasler CM, 2009, J AM DIET ASSOC, V109, P735, DOI 10.1016/j.jada.2009.02.023
   Holubková A, 2012, ACTA CHIM SLOVACA, V5, P186, DOI 10.2478/v10188-012-0029-8
   Hong J, 2016, J MED FOOD, V19, P549, DOI 10.1089/jmf.2015.3604
   Hong SA, 2017, ASIA PAC J CLIN NUTR, V26, P514, DOI 10.6133/apjcn.042016.03
   Hosseinpour-Niazi S, 2012, ARCH IRAN MED, V15, P538, DOI 012159/AIM.005
   Hu FB, 2002, CURR OPIN LIPIDOL, V13, P3, DOI 10.1097/00041433-200202000-00002
   Kahleova H, 2011, DIABETIC MED, V28, P549, DOI 10.1111/j.1464-5491.2010.03209.x
   Kaur J., 2014, Medical Sciences, V2, P140, DOI DOI 10.3390/MEDSCI2030140
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Keihanian F, 2018, J CELL PHYSIOL, V233, P4497, DOI 10.1002/jcp.26249
   Kim M, 2020, NUTR RES PRACT, V14, P252, DOI 10.4162/nrp.2020.14.3.252
   Klemsdal TO, 2010, NUTR METAB CARDIOVAS, V20, P195, DOI 10.1016/j.numecd.2009.03.010
   Ko SH, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010202
   Kurtoglu S, 2012, EUR J PEDIATR, V171, P1331, DOI 10.1007/s00431-012-1724-6
   LaHaye SA, 2005, CAN J CARDIOL, V21, P489
   Lear SA, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010015
   Lutsey PL, 2008, CIRCULATION, V117, P754, DOI 10.1161/CIRCULATIONAHA.107.716159
   McCarty MF, 2004, MED HYPOTHESES, V63, P813, DOI 10.1016/j.mehy.2002.11.004
   Mirmiran P, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-108
   Mirzababaei A, 2019, DIABETES METAB SYND, V13, P322, DOI 10.1016/j.dsx.2018.09.012
   Mirzaei M, 2018, INT J EPIDEMIOL, V47, P697, DOI 10.1093/ije/dyx231
   Miura K, 2004, AM J EPIDEMIOL, V159, P572, DOI 10.1093/aje/kwh085
   Mofrad MD, 2019, BRIT J NUTR, V121, P1049, DOI 10.1017/S0007114519000229
   Moghaddam M.B., 2012, WORLD APPL SCI J, V18, P1073, DOI [DOI 10.5829/idosi.wasj.2012.18.08.754, 10.5829/idosi.wasj.2012.18.08]
   Ness AR, 1997, J HUM HYPERTENS, V11, P343, DOI 10.1038/sj.jhh.1000423
   Park S, 2015, NUTRITION, V31, P111, DOI 10.1016/j.nut.2014.05.011
   Povel CM, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-133
   Practice Cardiology Research And, 2019, Cardiol Res Pract, V2019, P4301528, DOI 10.1155/2019/4301528
   Reaven G M, 2000, Curr Atheroscler Rep, V2, P503, DOI 10.1007/s11883-000-0050-z
   Shirani F, 2015, NUTRITION, V31, P1124, DOI 10.1016/j.nut.2015.04.013
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Srinivasan K, 2016, CRIT REV FOOD SCI, V56, P1488, DOI 10.1080/10408398.2013.772090
   Tucci SA, 2010, PHARMACEUTICALS-BASE, V3, P748, DOI 10.3390/ph3030748
   Utsugi MT, 2008, HYPERTENS RES, V31, P1435, DOI 10.1291/hypres.31.1435
   van Dam RM, 2005, BRIT J NUTR, V93, P573, DOI 10.1079/BJN20051453
   Vincent HK, 2010, J HUM NUTR DIET, V23, P20, DOI 10.1111/j.1365-277X.2009.00987.x
   Wang L, 2007, AM J CLIN NUTR, V86, P472, DOI 10.1093/ajcn/86.2.472
   Weng LC, 2013, NUTRIENTS, V5, P1719, DOI 10.3390/nu5051719
   Xun P, 2012, AM J CLIN NUTR, V95, P1023, DOI 10.3945/ajcn.111.027250
NR 56
TC 16
Z9 16
U1 1
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD AUG 24
PY 2021
VL 21
IS 1
AR 1587
DI 10.1186/s12889-021-11590-2
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA UE6OT
UT WOS:000688005800001
PM 34429094
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Millar, CL
   Duclos, Q
   Garcia, C
   Norris, GH
   Lemos, BS
   DiMarco, DM
   Fernandez, ML
   Blesso, CN
AF Millar, Courtney L.
   Duclos, Quinn
   Garcia, Chelsea
   Norris, Gregory H.
   Lemos, Bruno S.
   DiMarco, Diana M.
   Fernandez, Maria Luz
   Blesso, Christopher N.
TI Effects of Freeze-Dried Grape Powder on High-Density Lipoprotein
   Function in Adults with Metabolic Syndrome: A Randomized Controlled
   Pilot Study
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE grape; HDL; PON1; metabolic syndrome; polyphenols
ID CHOLESTEROL EFFLUX CAPACITY; APOLIPOPROTEIN-A-I; CARDIOVASCULAR-DISEASE;
   SERUM PARAOXONASE; OXIDATIVE STRESS; RICH EXTRACT; HDL; ATHEROSCLEROSIS;
   ACCUMULATION; INHIBITION
AB Background: High-density lipoprotein (HDL) particles are protective against atherosclerosis. However, HDL function is impaired in metabolic syndrome (MetS) due to low-grade inflammation and dyslipidemia. Foods containing polyphenols, such as grapes, may prevent HDL dysfunction via antioxidant or anti-inflammatory effects. We evaluated the effects of grape powder ingestion on measures of HDL function in adults with MetS. Methods: Twenty adults (age: 32-70 years; body mass index: 25.3-45.4kg/m(2)) consumed either 60 grams/day of freeze-dried grape powder (GRAPE) or a placebo for 4 weeks, separated by a 3-week washout period, in a randomized, double-blind crossover study. The primary outcome was serum paraoxonase-1 (PON1) arylesterase activity, a measure of HDL antioxidant function. Secondary outcomes included PON1 lactonase activity, plasma lipids, metabolic markers, cholesterol efflux capacity, and other HDL functional markers. Results: After 4 weeks, GRAPE did not alter the serum PON1 activity or other markers of HDL function compared with placebo. Measures of HDL function were positively correlated with each other and inversely with measures of insulin resistance and inflammation. GRAPE intake led to a significant reduction in fasting plasma triglycerides compared with placebo (P=0.032). No other significant effects of GRAPE were observed for other plasma lipids, anthropometrics, or metabolic measures. Conclusions: Grape powder consumption did not impact HDL function in this cohort of adults with MetS. However, it was shown to improve fasting triglycerides, a risk factor for cardiovascular disease.
C1 [Millar, Courtney L.; Duclos, Quinn; Garcia, Chelsea; Norris, Gregory H.; Lemos, Bruno S.; DiMarco, Diana M.; Fernandez, Maria Luz; Blesso, Christopher N.] Univ Connecticut, Dept Nutr Sci, 3624 Horsebarn Rd Ext,U-4017, Storrs, CT 06269 USA.
C3 University of Connecticut
RP Blesso, CN (corresponding author), Univ Connecticut, Dept Nutr Sci, 3624 Horsebarn Rd Ext,U-4017, Storrs, CT 06269 USA.
EM christopher.blesso@uconn.edu
RI Blesso, Christopher/N-9495-2014
OI Lemos, Bruno/0000-0002-3859-6175; Garcia, Chelsea/0000-0002-7681-695X
FU California Table Grape Commission
FX This work was supported by an award to C.N.B. from the California Table
   Grape Commission. This trial is registered at clinicaltrials.gov, trial
   number NCT02542176.
CR Aharoni S, 2013, ATHEROSCLEROSIS, V228, P353, DOI 10.1016/j.atherosclerosis.2013.03.005
   Barona J, 2012, J NUTR, V142, P1626, DOI 10.3945/jn.112.162743
   Bhattacharyya T, 2008, JAMA-J AM MED ASSOC, V299, P1265, DOI 10.1001/jama.299.11.1265
   Blesso CN, 2013, METABOLISM, V62, P400, DOI 10.1016/j.metabol.2012.08.014
   Davidson WS, 2016, J LIPID RES, V57, P674, DOI 10.1194/jlr.M066613
   de Souza JA, 2008, ATHEROSCLEROSIS, V197, P84, DOI 10.1016/j.atherosclerosis.2007.08.009
   Farrell N, 2015, FOOD FUNCT, V6, P1278, DOI [10.1039/c4fo01036a, 10.1039/C4FO01036A]
   Gall J, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.116.004808
   Ganjali S, 2017, PHARMACOL RES, V119, P208, DOI 10.1016/j.phrs.2017.02.008
   Gorinstein S, 2006, J AGR FOOD CHEM, V54, P1887, DOI 10.1021/jf058171g
   Han CY, 2006, ARTERIOSCL THROM VAS, V26, P1806, DOI 10.1161/01.ATV.0000227472.70734.ad
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Jia Y, 2013, BIOORG MED CHEM LETT, V23, P4185, DOI 10.1016/j.bmcl.2013.05.030
   Kappelle PJWH, 2011, ARCH MED RES, V42, P219, DOI 10.1016/j.arcmed.2011.05.002
   Khera AV, 2011, NEW ENGL J MED, V364, P127, DOI 10.1056/NEJMoa1001689
   Khersonsky O, 2005, BIOCHEMISTRY-US, V44, P6371, DOI 10.1021/bi047440d
   Kingwell BA, 2014, NAT REV DRUG DISCOV, V13, P445, DOI 10.1038/nrd4279
   Kosmas CE, 2018, Drugs. Context, V7
   Kotani K, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/481437
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Millar CL, 2017, ADV NUTR, V8, P226, DOI 10.3945/an.116.014050
   Miller M, 2011, CIRCULATION, V123, P2292, DOI 10.1161/CIR.0b013e3182160726
   Naruszewicz M, 2007, ATHEROSCLEROSIS, V194, pE179, DOI 10.1016/j.atherosclerosis.2006.12.032
   Pérez-Jiménez J, 2008, NUTR RES REV, V21, P158, DOI 10.1017/S0954422408125124
   Qin Y, 2009, AM J CLIN NUTR, V90, P485, DOI 10.3945/ajcn.2009.27814
   Rader DJ, 2016, CELL METAB, V23, P405, DOI 10.1016/j.cmet.2016.01.005
   Rohatgi A, 2014, NEW ENGL J MED, V371, P2383, DOI 10.1056/NEJMoa1409065
   Rosenblat M, 2005, ATHEROSCLEROSIS, V179, P69, DOI 10.1016/j.atherosclerosis.2004.10.028
   Smith JD, 2010, ARTERIOSCL THROM VAS, V30, P151, DOI 10.1161/ATVBAHA.108.179226
   Sorci-Thomas MG, 2013, J CARDIOVASC PHARM, V62, P239, DOI 10.1097/FJC.0b013e31829d48a5
   Stocker R, 2004, AM J CLIN NUTR, V79, P123
   Tang WHW, 2012, ARTERIOSCL THROM VAS, V32, P2803, DOI 10.1161/ATVBAHA.112.253930
   Tölle M, 2012, CARDIOVASC RES, V94, P154, DOI 10.1093/cvr/cvs089
   Vaisar T, 2007, J CLIN INVEST, V117, P746, DOI 10.1172/JCI26206
   Vaisar T, 2015, J LIPID RES, V56, P1519, DOI 10.1194/jlr.M059089
   Wang DL, 2012, CIRC RES, V111, P967, DOI [10.1161/circresaha.112.266502, 10.1161/CIRCRESAHA.112.266502]
   Wang Y, 2012, ATHEROSCLEROSIS, V223, P299, DOI 10.1016/j.atherosclerosis.2012.06.004
   Yamakoshi J, 1999, ATHEROSCLEROSIS, V142, P139, DOI 10.1016/S0021-9150(98)00230-5
   Zagayko AL, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/593761
   Zern TL, 2005, J NUTR, V135, P1911, DOI 10.1093/jn/135.8.1911
   Zern TL, 2003, J NUTR, V133, P2268, DOI 10.1093/jn/133.7.2268
   Zhu YN, 2014, J CLIN ENDOCR METAB, V99, P561, DOI 10.1210/jc.2013-2845
   Zunino SJ, 2014, BRIT J NUTR, V112, P369, DOI 10.1017/S0007114514000890
NR 43
TC 18
Z9 21
U1 0
U2 18
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD NOV
PY 2018
VL 16
IS 9
BP 464
EP 469
DI 10.1089/met.2018.0052
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GY9BQ
UT WOS:000448934400002
PM 30129815
DA 2025-06-11
ER

PT J
AU Akboga, MK
   Canpolat, U
   Yuksel, M
   Yayla, C
   Yilmaz, S
   Turak, O
   Ozeke, O
   Topaloglu, S
   Aras, D
AF Akboga, Mehmet Kadri
   Canpolat, Ugur
   Yuksel, Murat
   Yayla, Cagri
   Yilmaz, Samet
   Turak, Osman
   Ozeke, Ozcan
   Topaloglu, Serkan
   Aras, Dursun
TI Platelet to lymphocyte ratio as a novel indicator of inflammation is
   correlated with the severity of metabolic syndrome: A single center
   large-scale study
SO PLATELETS
LA English
DT Article
DE C-reactive protein; inflammation; metabolic syndrome; platelet to
   lymphocyte ratio
ID C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; RISK;
   ATHEROSCLEROSIS; ASSOCIATION; DYSFUNCTION; COMPONENTS; PREDICTOR;
   MORTALITY
AB Metabolic syndrome (MetS) as a cluster of several cardio-metabolic components is rapidly growing public-health problem worldwide and significantly associated with poor cardiovascular outcomes. Increased visceral adiposity activates the important pathways connecting low-grade chronic inflammation, oxidative stress and blood coagulation. Recently, platelet to lymphocyte ratio (PLR) has been evidenced as a novel indirect inflammatory marker. Therefore, for the first time, we aimed to investigate the association of PLR with both the presence and severity of MetS. In this cross-sectional study, a total of 1146 participants were enrolled (n=539 with MetS and n=607 without MetS). MetS was defined according to NCEP-ATP III criteria. MetS (+) group revealed significantly higher PLR and C-reactive protein (CRP) levels as compared to MetS (-) group (p<0.05). There was a graded relationship between increasing number of MetS components and PLR (p<0.05). Also, PLR was positively correlated with CRP level (r=0.163, p<0.001). In multivariate regression analysis, PLR [1.121 (1.113-1.135), p<0.001], CRP [1.044 (1.029-1.060), p<0.001], and age [1.030 (1.017-1.043), p<0.001] were remained as independent predictors for the presence of MetS. In conclusion, our findings showed that increased PLR was significantly associated with both the presence and severity of MetS which was linked to systemic inflammation based on the correlation between PLR and CRP. As PLR is an easily available, simple and cheap indirect indicator of inflammation, it can be used in clinical practice as a predictor of MetS.
C1 [Akboga, Mehmet Kadri; Canpolat, Ugur; Yayla, Cagri; Yilmaz, Samet; Turak, Osman; Ozeke, Ozcan; Topaloglu, Serkan; Aras, Dursun] Turkiye Yuksek Ihtisas Training & Res Hosp, Cardiol Clin, Ankara, Turkey.
   [Yuksel, Murat] Dicle Univ, Fac Med, Dept Cardiol, Diyarbakir, Turkey.
C3 Turkey Specialized Higher Education & Research Hospital; Dicle
   University
RP Akboga, MK (corresponding author), Turkiye Yuksek Ihtisas Training & Res Hosp, Cardiol Clin, Cardiol, Ankara, Turkey.
EM mkakboga@yahoo.com
RI Yılmaz, Samet/Q-5077-2016; Özeke, Özcan/N-1871-2015; Yuksel,
   Murat/B-7287-2013; Akboga, Mehmet/AAS-8818-2020; Ozeke,
   Ozcan/AAS-8730-2020; Canpolat, Ugur/S-3482-2018; YAYLA,
   CAGRI/B-9270-2019
OI Ozeke, Ozcan/0000-0002-4770-8159; Canpolat, Ugur/0000-0002-4250-1706;
   YAYLA, CAGRI/0000-0002-5302-4052
CR Akboga MK, 2016, ANGIOLOGY, V67, P21, DOI 10.1177/0003319715574625
   Akboga MK, 2016, ANGIOLOGY, V67, P89, DOI 10.1177/0003319715583186
   Akboga MK, 2015, ANATOL J CARDIOL, V15, P380, DOI 10.5152/akd.2014.5399
   Akboga MK, 2015, ATHEROSCLEROSIS, V240, P110, DOI 10.1016/j.atherosclerosis.2015.02.051
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Arbel Y, 2015, AM J CARDIOL, V115, P283, DOI 10.1016/j.amjcard.2014.10.037
   Azab B, 2012, J THROMB THROMBOLYS, V34, P326, DOI 10.1007/s11239-012-0718-6
   Balta S, 2015, PLATELETS, V26, P680, DOI 10.3109/09537104.2014.979340
   Cai DS, 2012, AGING-US, V4, P98, DOI 10.18632/aging.100431
   Chen Liang-Kung, 2006, J Chin Med Assoc, V69, P248
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Després JP, 2012, CAN J CARDIOL, V28, P642, DOI 10.1016/j.cjca.2012.06.004
   Gary T, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0067688
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Haffner SM, 2006, AM J CARDIOL, V97, p3A, DOI 10.1016/j.amjcard.2005.11.010
   Horne BD, 2005, J AM COLL CARDIOL, V45, P1638, DOI 10.1016/j.jacc.2005.02.054
   Hui WS, 2010, EUR J EPIDEMIOL, V25, P375, DOI 10.1007/s10654-010-9459-z
   Klöting N, 2014, REV ENDOCR METAB DIS, V15, P277, DOI 10.1007/s11154-014-9301-0
   Koenig W, 1999, CIRCULATION, V99, P237, DOI 10.1161/01.CIR.99.2.237
   Kotani K, 2007, CLIN CHEM LAB MED, V45, P376, DOI 10.1515/CCLM.2007.063
   Kressel G, 2009, ATHEROSCLEROSIS, V202, P263, DOI 10.1016/j.atherosclerosis.2008.04.012
   Lim HJ, 2015, PLATELETS, V26, P758, DOI 10.3109/09537104.2014.995613
   Mahajan A, 2012, ATHEROSCLEROSIS, V220, P275, DOI 10.1016/j.atherosclerosis.2011.10.031
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Oda E, 2010, INTERNAL MED, V49, P117, DOI 10.2169/internalmedicine.49.2670
   Odegaard JI, 2013, SCIENCE, V339, P172, DOI 10.1126/science.1230721
   Ommen SR, 1997, AM J CARDIOL, V79, P812, DOI 10.1016/S0002-9149(96)00878-8
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Ugur M, 2014, BLOOD COAGUL FIBRIN, V25, P806, DOI 10.1097/MBC.0000000000000150
   van Rooy MJ, 2015, THROMB RES, V135, P434, DOI 10.1016/j.thromres.2014.12.030
   Wang YB, 2013, CURR PHARM DESIGN, V19, P4799, DOI 10.2174/1381612811319270002
   Wang YY, 2004, J DIABETES COMPLICAT, V18, P322, DOI 10.1016/S1056-8727(04)00003-0
   Yayla Ç, 2015, ANGIOLOGY, V66, P831, DOI 10.1177/0003319715573658
   Yudkin JS, 1999, ARTERIOSCL THROM VAS, V19, P972, DOI 10.1161/01.ATV.19.4.972
NR 35
TC 57
Z9 61
U1 0
U2 9
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0953-7104
EI 1369-1635
J9 PLATELETS
JI Platelets
PD FEB 17
PY 2016
VL 27
IS 2
BP 178
EP 183
DI 10.3109/09537104.2015.1064518
PG 6
WC Cell Biology; Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Hematology
GA DF9ZF
UT WOS:000371720500013
PM 26196312
DA 2025-06-11
ER

PT J
AU Shivpuri, S
   Allison, MA
   Macera, CA
   Lindsay, S
   Gallo, LC
AF Shivpuri, Smriti
   Allison, Matthew A.
   Macera, Caroline A.
   Lindsay, Suzanne
   Gallo, Linda C.
TI Associations Between Nocturnal Blood Pressure Dipping and the Metabolic
   Syndrome in High- Vs. Low-Acculturated Mexican American Women
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
DE acculturation; blood pressure; blood pressure dipping; Hispanic;
   hypertension; metabolic syndrome
ID HYPERTENSIVE PATIENTS; SYNDROME SCORE; PHYSICAL-ACTIVITY; PROFILE;
   STRESS; HEALTH; FALL; US; PATTERN; EVENTS
AB BACKGROUND
   Less nocturnal blood pressure (BP) dipping has been associated with greater odds for the metabolic syndrome (MetS), a constellation of risk factors associated with cardiovascular disease (CVD). Little work has examined this association in Hispanics, who have elevated rates of MetS, or investigated differences in this relationship by level of acculturation. The purpose of this study was to examine the association between BP dipping and MetS in Hispanic women and to determine if this association is moderated by acculturation status.
   METHODS
   Two hundred eighty-six Mexican American women underwent assessment of MetS components (BP, waist circumference, fasting glucose, high-density lipoprotein cholesterol, and triglycerides) and completed a 36-hour ambulatory BP monitoring protocol, during which systolic BP (SBP) and diastolic BP readings were obtained. Nocturnal BP dipping was calculated as the percentage difference between average daytime and nighttime BP. Acculturation was defined by the language (Spanish, English) in which participants preferred to complete study instruments.
   RESULTS
   Although no significant main effects for BP dipping or acculturation emerged for MetS, the SBP dipping by acculturation interaction was significantly related to MetS (P < 0.01). Simple slope analyses revealed that less SBP dipping related to greater odds of MetS in high-acculturated women, but SBP dipping and MetS were unrelated in low-acculturated women.
   CONCLUSIONS
   The strength of the association between BP dipping and CVD risk (as measured by MetS) appears to vary by acculturation in Hispanic women. Future studies should explore mechanisms behind the BP dipping and CVD risk association and relevant modifying factors.
C1 [Shivpuri, Smriti] Univ Calif San Diego, San Diego State Univ, Joint Doctoral Program Clin Psychol, San Diego, CA 92103 USA.
   [Allison, Matthew A.] Univ Calif San Diego, Dept Family & Prevent Med, San Diego, CA 92103 USA.
   [Macera, Caroline A.; Lindsay, Suzanne] San Diego State Univ, Grad Sch Publ Hlth, San Diego, CA 92182 USA.
   [Gallo, Linda C.] San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA.
C3 California State University System; San Diego State University;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   California State University System; San Diego State University;
   California State University System; San Diego State University
RP Shivpuri, S (corresponding author), Univ Calif San Diego, San Diego State Univ, Joint Doctoral Program Clin Psychol, San Diego, CA 92103 USA.
EM smriti.shivpuri@gmail.com
OI Allison, Matthew/0000-0003-0777-8272; Gallo, Linda
   C./0000-0002-3678-5888
FU National Heart Lung and Blood Institute, National Institutes of Health
   (NHLBI/NIH) [1R01HL081604, 1T32HL079891]
FX This work was supported by grants from the National Heart Lung and Blood
   Institute, National Institutes of Health (NHLBI/NIH) (1R01HL081604;
   1T32HL079891 to SS).
CR Abraído-Lanza AF, 2006, AM J PUBLIC HEALTH, V96, P1342, DOI 10.2105/AJPH.2005.064980
   Arcia E, 2001, SOC SCI MED, V53, P41, DOI 10.1016/S0277-9536(00)00310-5
   Ayala DE, 2009, CHRONOBIOL INT, V26, P1189, DOI 10.1080/07420520903206294
   Bastos Jose Mesquita, 2007, Rev Port Cardiol, V26, P731
   Baumgart, 1998, Blood Press Monit, V3, P303
   Birkenhäger AM, 2007, NETH J MED, V65, P127
   Bouhanick B, 2008, DIABETES METAB, V34, P560, DOI 10.1016/j.diabet.2008.05.005
   Cabassa LJ, 2003, HISPANIC J BEHAV SCI, V25, P127, DOI 10.1177/0739986303025002001
   Cavelaars M, 2004, J HYPERTENS, V22, P2303, DOI 10.1097/00004872-200412000-00012
   Cruz TH, 2008, HISPANIC J BEHAV SCI, V30, P425, DOI 10.1177/0739986308323653
   Cuspidi C, 2005, BLOOD PRESS MONIT, V10, P175, DOI 10.1097/01.mbp.0000170921.55412.02
   Cuspidi C, 2004, BLOOD PRESSURE, V13, P230, DOI 10.1080/08037050410021540
   Ervin R Bethene, 2009, Natl Health Stat Report, P1
   Friedman O, 2009, INTEGR BLOOD PRESS C, V2, P25
   Gallo LC, 2011, ANN BEHAV MED, V41, P21, DOI 10.1007/s12160-010-9233-1
   Gallo LC, 2009, PSYCHOSOM MED, V71, P756, DOI 10.1097/PSY.0b013e3181b0d2b4
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hajjar I, 2010, AM J HYPERTENS, V23, P17, DOI 10.1038/ajh.2009.187
   Hassan MO, 2007, OBESITY, V15, P2445, DOI 10.1038/oby.2007.290
   Hermida RC, 2011, CHRONOBIOL INT, V28, P509, DOI 10.3109/07420528.2011.580871
   Hermida RC, 2009, AM J HYPERTENS, V22, P307, DOI 10.1038/ajh.2008.358
   Kabutoya T, 2010, AM J HYPERTENS, V23, P749, DOI 10.1038/ajh.2010.45
   Kanbay M, 2008, CLIN EXP HYPERTENS, V30, P585, DOI 10.1080/10641960802251974
   Kanbay M, 2012, INT UROL NEPHROL, V44, P173, DOI 10.1007/s11255-011-0027-6
   Kaplan Norman M, 2011, Curr Cardiol Rep, V13, P517, DOI 10.1007/s11886-011-0213-2
   Kengne AP, 2009, HYPERTENSION, V54, P399, DOI 10.1161/HYPERTENSIONAHA.109.133041
   MARLER MR, 1988, STAT MED, V7, P697, DOI 10.1002/sim.4780070608
   Miller DB, 2002, METABOLISM, V51, P5, DOI 10.1053/meta.2002.33184
   NEELEY WE, 1972, CLIN CHEM, V18, P509
   Nelson Tamara, 2007, Metabolic Syndrome and Related Disorders, V5, P262, DOI 10.1089/met.2006.0035
   O'Brien E, 2003, J HYPERTENS, V21, P821, DOI 10.1097/00004872-200305000-00001
   O'Brien E, 2007, HYPERTENSION, V49, P769, DOI 10.1161/01.HYP.0000258152.29476.de
   O'Shea JC, 2000, AM J HYPERTENS, V13, P601, DOI 10.1016/S0895-7061(99)00263-0
   Palatini P, 2004, J HYPERTENS, V22, P2269, DOI 10.1097/00004872-200412000-00007
   Peixoto AJ, 2007, KIDNEY INT, V71, P855, DOI 10.1038/sj.ki.5002130
   Plerdomenico SD, 2010, BLOOD PRESS MONIT, V15, P1, DOI 10.1097/MBP.0b013e3283360ed1
   Rojas R, 2010, SALUD PUBLICA MEXICO, V52, pS11, DOI 10.1590/S0036-36342010000700004
   Staessen JA, 2001, BLOOD PRESS MONIT, V6, P355, DOI 10.1097/00126097-200112000-00016
   Thomson MD, 2009, SOC SCI MED, V69, P983, DOI 10.1016/j.socscimed.2009.05.011
   Tull ES, 2003, J NATL MED ASSOC, V95, P560
   Ukkola O, 2009, HYPERTENS RES, V32, P1022, DOI 10.1038/hr.2009.137
   Vittinghoff E, 2007, AM J EPIDEMIOL, V165, P710, DOI 10.1093/aje/kwk052
   Vyssoulis G, 2008, BLOOD PRESS MONIT, V13, P251, DOI 10.1097/MBP.0b013e32830719c0
   Vyssoulis GR, 2007, BLOOD PRESS MONIT, V12, P351, DOI 10.1097/MBP.0b013e3282cb5ad3
   Wang JG, 2005, HYPERTENSION, V45, P907, DOI 10.1161/01.HYP.0000165020.14745.79
   Warnick GR, 2000, CLIN CHEM LAB MED, V38, P287, DOI 10.1515/CCLM.2000.041
NR 46
TC 3
Z9 4
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0895-7061
EI 1941-7225
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD AUG
PY 2013
VL 26
IS 8
BP 1030
EP 1036
DI 10.1093/ajh/hpt061
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA 182CO
UT WOS:000321718300013
PM 23645325
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Lutgers, HL
   Graaff, R
   de Vries, R
   Smit, AJ
   Dullaart, RPF
AF Lutgers, Helen L.
   Graaff, Reindert
   de Vries, Rindert
   Smit, Andries J.
   Dullaart, Robin P. F.
TI Carotid artery intima media thickness associates with skin
   autofluoresence in non-diabetic subjects without clinically manifest
   cardiovascular disease
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE Intima media thickness; lipoproteins; metabolic syndrome;
   paraoxoanase-1; skin autofluorescence
ID GLYCATION END-PRODUCTS; TYPE-2 DIABETES-MELLITUS; C-REACTIVE PROTEIN;
   METABOLIC SYNDROME; MYOCARDIAL-INFARCTION; DENSITY-LIPOPROTEIN;
   OXIDATIVE STRESS; RISK; COMPLICATIONS; ACCUMULATION
AB P>Background
   Skin autofluorescence (skin AF) is determined in part by accumulation of advanced glycation end products. Increased skin AF was shown previously to predict cardiovascular events independently of conventional risk factors. We determined the association of carotid artery intima media thickness (IMT), a marker of subclinical cardiovascular disease, with skin AF in subjects without diabetes or clinically manifest cardiovascular disease.
   Methods
   In a cross-sectional observational study, IMT, skin AF, lipids and apolipoproteins, C-reactive protein (CRP), insulin resistance and paraoxonase-1 activity were measured in 59 non-smoking, non-obese subjects without diabetes mellitus and cardiovascular disease (32 women; 12 subjects with metabolic syndrome (MetS)).
   Results
   In univariate analyses, skin AF was correlated with IMT (r = 0 center dot 265, P = 0 center dot 042), but not significantly with clinical factors, (apo)lipoproteins, CRP, insulin resistance and paraoxonase-1. In multiple linear regression analyses, IMT was determined independently by age (beta = 0 center dot 549, P < 0 center dot 001), apo B (beta = 0 center dot 236, P = 0 center dot 022) and skin AF (beta = 0 center dot 216, P = 0 center dot 035). IMT was also associated with skin AF (beta = 0 center dot 213, P = 0 center dot 046) in a model which included the presence of MetS.
   Conclusions
   IMT is positively related to skin AF, independently of clinical factors, (apo)lipoproteins and MetS, suggesting that skin AF represents a determinant of subclinical atherosclerosis. Increased skin AF may reflect early abnormalities in processes involved in atherosclerosis development.
C1 [Lutgers, Helen L.; de Vries, Rindert; Dullaart, Robin P. F.] Univ Med Ctr Groningen, Dept Endocrinol & Metab, NL-9700 RB Groningen, Netherlands.
   [Graaff, Reindert] Univ Med Ctr Groningen, Dept Biomed Engn, NL-9700 RB Groningen, Netherlands.
   [Smit, Andries J.] Univ Med Ctr Groningen, Dept Internal Med, NL-9700 RB Groningen, Netherlands.
   [Smit, Andries J.] Univ Groningen, NL-9700 RB Groningen, Netherlands.
C3 University of Groningen; University of Groningen; University of
   Groningen; University of Groningen
RP Lutgers, HL (corresponding author), Univ Med Ctr Groningen, Dept Endocrinol & Metab, POB 30001, NL-9700 RB Groningen, Netherlands.
EM h.l.lutgers@int.umcg.nl
RI Lutgers, Helen/MFK-2548-2025; Graaff, Reindert/G-8941-2011
FU Dutch Diabetes Research Foundation [2001.00.012]
FX This study is in part supported by grant 2001.00.012 from the Dutch
   Diabetes Research Foundation. Plasma lipid and apo-lipoproteins were
   determined in the laboratory of Dr. L.D. Dikkeschei, Ph.D., Laboratory
   of Clinical Chemistry, Isala Clinics, Zwolle. Serum paraoxonase-1
   activity was measured by Dr. H.A.M. Voorbij, Laboratory of Clinical
   Chemistry and Hematology, University Medical Centre, Utrecht, The
   Netherlands.
CR Baynes JW, 1999, DIABETES, V48, P1, DOI 10.2337/diabetes.48.1.1
   Baynes JW, 2000, FREE RADICAL BIO MED, V28, P1708, DOI 10.1016/S0891-5849(00)00228-8
   Blaauw J, 2006, AM J OBSTET GYNECOL, V195, P717, DOI 10.1016/j.ajog.2006.06.086
   Bos M B, 2007, Ned Tijdschr Geneeskd, V151, P2382
   de Leeuw K, 2007, RHEUMATOLOGY, V46, P1551, DOI 10.1093/rheumatology/kem215
   den Hollander NC, 2007, J INHERIT METAB DIS, V30, P916, DOI 10.1007/s10545-007-0507-0
   Dullaart RPF, 2009, CLIN ENDOCRINOL, V70, P221, DOI 10.1111/j.1365-2265.2008.03306.x
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Keulen ETP, 2002, ARTERIOSCL THROM VAS, V22, P283, DOI 10.1161/hq0202.104100
   Koetsier M, 2009, OPT EXPRESS, V17, P509, DOI 10.1364/OE.17.000509
   Lutgers HL, 2009, DIABETOLOGIA, V52, P789, DOI 10.1007/s00125-009-1308-9
   Lutgers HL, 2006, DIABETES CARE, V29, P2654, DOI 10.2337/dc05-2173
   Mackness M, 2004, CURR OPIN LIPIDOL, V15, P399, DOI 10.1097/01.mol.0000137227.54278.29
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Meerwaldt R, 2004, DIABETOLOGIA, V47, P1324, DOI 10.1007/s00125-004-1451-2
   Meerwaldt R, 2007, DIABETES CARE, V30, P107, DOI 10.2337/dc06-1391
   MONNIER VM, 1986, NEW ENGL J MED, V314, P403, DOI 10.1056/NEJM198602133140702
   MONNIER VM, 1990, J GERONTOL, V45, pB105, DOI 10.1093/geronj/45.4.B105
   Mulder DJ, 2009, NETH HEART J, V17, P162, DOI 10.1007/BF03086239
   Mulder DJ, 2008, ATHEROSCLEROSIS, V197, P217, DOI 10.1016/j.atherosclerosis.2007.03.027
   O'Leary DH, 1999, NEW ENGL J MED, V340, P14, DOI 10.1056/NEJM199901073400103
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   Schleicher ED, 1997, J CLIN INVEST, V99, P457, DOI 10.1172/JCI119180
   Selvin E, 2010, NEW ENGL J MED, V362, P800, DOI 10.1056/NEJMoa0908359
   SELZER RH, 1994, ATHEROSCLEROSIS, V111, P1, DOI 10.1016/0021-9150(94)90186-4
   Simera I, 2010, EUR J CLIN INVEST, V40, P35, DOI 10.1111/j.1365-2362.2009.02234.x
   Stitt AW, 1997, MOL MED, V3, P617, DOI 10.1007/BF03401819
   van Himbergen TM, 2005, J LIPID RES, V46, P445, DOI 10.1194/jlr.M400052-JLR200
   Watson AD, 1995, J CLIN INVEST, V96, P2882, DOI 10.1172/JCI118359
   WILLIAMS K, 2003, CIRCULATION, V11, P108
NR 30
TC 37
Z9 39
U1 0
U2 4
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0014-2972
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD SEP
PY 2010
VL 40
IS 9
BP 812
EP 817
DI 10.1111/j.1365-2362.2010.02329.x
PG 6
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 635PS
UT WOS:000280669100006
PM 20597962
DA 2025-06-11
ER

PT J
AU Karatsoreos, IN
AF Karatsoreos, Ilia N.
TI Effects of Circadian Disruption on Mental and Physical Health
SO CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
LA English
DT Review
DE Biological rhythms; Sleep; Aging; Obesity; Metabolic syndrome;
   Plasticity; Prefrontal; Hippocampus; Learning; Depression; Circadian
   disruption
ID SHIFT WORK; WEIGHT-GAIN; LIGHT; RHYTHMS; NIGHT; CONSEQUENCES;
   DEPRESSION; DISORDER; CLOCKS; BRAIN
AB Circadian (daily) rhythms in physiology and behavior are phylogenetically ancient and are present in almost all plants and animals. In mammals, these rhythms are generated by a master circadian clock in the suprachiasmatic nucleus of the hypothalamus, which in turn synchronizes "peripheral oscillators" throughout the brain and body in almost all cell types and organ systems. Although circadian rhythms are phylogenetically ancient, modern industrialized society and the ubiquity of electric lighting has resulted in a fundamental alteration in the relationship between an individual's endogenous circadian rhythmicity and the external environment. The ramifications of this desynchronization for mental and physical health are not fully understood, although numerous lines of evidence are emerging that link defects in circadian timing with negative health outcomes. This article explores the function of the circadian system, the effects of disrupted clocks on the brain and body, and how these effects impact mental and physical health.
C1 Washington State Univ, Dept Vet & Comparat Anat Pharmacol & Physiol, Pullman, WA 99164 USA.
C3 Washington State University
RP Karatsoreos, IN (corresponding author), Washington State Univ, Dept Vet & Comparat Anat Pharmacol & Physiol, 205 Wegner Hall, Pullman, WA 99164 USA.
EM iliak@vetmed.wsu.edu
RI Karatsoreos, Ilia/AAR-8774-2020
FU Canadian Institute of Health Research
FX Conflicts of interest: I.N. Karatsoreos: has received grant support from
   the Canadian Institute of Health Research.
CR Boivin DB, 2007, SLEEP MED, V8, P578, DOI 10.1016/j.sleep.2007.03.015
   Buhr ED, 2010, SCIENCE, V330, P379, DOI 10.1126/science.1195262
   Butler MP, 2009, HORMONES, BRAIN AND BEHAVIOR, VOLS 1-5, 2ND EDITION, P473
   Cain SW, 2004, PHYSIOL BEHAV, V82, P339, DOI 10.1016/j.physbeh.2004.04.004
   Cheng MY, 2006, J COMP NEUROL, V498, P796, DOI 10.1002/cne.21087
   Cheng MY, 2002, NATURE, V417, P405, DOI 10.1038/417405a
   Cho KW, 2001, NAT NEUROSCI, V4, P567, DOI 10.1038/88384
   Davidson AJ, 2006, CURR BIOL, V16, pR914, DOI 10.1016/j.cub.2006.09.058
   Davis S, 2001, JNCI-J NATL CANCER I, V93, P1557, DOI 10.1093/jnci/93.20.1557
   de Bodinat C, 2010, NAT REV DRUG DISCOV, V9, P628, DOI 10.1038/nrd3140
   Emens J, 2009, PSYCHIAT RES, V168, P259, DOI 10.1016/j.psychres.2009.04.009
   Fonken LK, 2010, P NATL ACAD SCI USA, V107, P18664, DOI 10.1073/pnas.1008734107
   Gibson EM, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015267
   HALAAS JL, 1995, SCIENCE, V269, P543, DOI 10.1126/science.7624777
   Hastings MH, 2003, NAT REV NEUROSCI, V4, P649, DOI 10.1038/nrn1177
   Haus E, 2006, CANCER CAUSE CONTROL, V17, P489, DOI 10.1007/s10552-005-9015-4
   Hurd MW, 1998, J BIOL RHYTHM, V13, P430, DOI 10.1177/074873098129000255
   Karatsoreos IN, 2011, P NATL ACAD SCI USA, V108, P1657, DOI 10.1073/pnas.1018375108
   King DP, 2000, ANNU REV NEUROSCI, V23, P713, DOI 10.1146/annurev.neuro.23.1.713
   Magnusson A, 2003, CHRONOBIOL INT, V20, P189, DOI 10.1081/CBI-120019310
   Marcheva B, 2010, NATURE, V466, P627, DOI 10.1038/nature09253
   Mendlewicz J, 2009, CNS DRUGS, V23, P15, DOI 10.2165/11318630-000000000-00000
   Mistlberger RE, 2009, EUR J NEUROSCI, V30, P1718, DOI 10.1111/j.1460-9568.2009.06965.x
   Moore-Ede M.C., 1984, CLOCKS TIME US PHYSL
   Nakamura Y, 2011, J ALLERGY CLIN IMMUN, V127, P1038, DOI 10.1016/j.jaci.2011.02.006
   Niedhammer I, 1996, INT J OBESITY, V20, P625
   Rosenwasser AM, 2010, NEUROSCI BIOBEHAV R, V34, P1249, DOI 10.1016/j.neubiorev.2010.03.004
   Samuels BA, 2011, EUR J NEUROSCI, V33, P1152, DOI 10.1111/j.1460-9568.2011.07614.x
   Scheer FAJL, 2009, P NATL ACAD SCI USA, V106, P4453, DOI 10.1073/pnas.0808180106
   Stevens RG, 2005, EPIDEMIOLOGY, V16, P254, DOI 10.1097/01.ede.0000152525.21924.54
   Suwazono Y, 2008, OBESITY, V16, P1887, DOI 10.1038/oby.2008.298
   Turek FW, 2007, INT CLIN PSYCHOPHARM, V22, pS1, DOI 10.1097/01.yic.0000277956.93777.6a
   Turek FW, 2005, SCIENCE, V308, P1043, DOI 10.1126/science.1108750
   Van Cauter E, 2008, SLEEP MED, V9, pS23, DOI 10.1016/S1389-9457(08)70013-3
   Van Gelder RN, 2002, J NEUROGENET, V16, P181, DOI 10.1080/01677060215306
   VANCAUTER E, 1986, PERSPECT BIOL MED, V29, P510
   VanHeek M, 1997, J CLIN INVEST, V99, P385, DOI 10.1172/JCI119171
   Wirz-Justice A, 2006, INT CLIN PSYCHOPHARM, V21, pS11, DOI 10.1097/01.yic.0000195660.37267.cf
   Wirz-Justice A, 2009, J AFFECT DISORDERS, V116, P159, DOI 10.1016/j.jad.2009.04.024
   Yamazaki S, 2000, SCIENCE, V288, P682, DOI 10.1126/science.288.5466.682
NR 40
TC 58
Z9 71
U1 1
U2 45
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1528-4042
EI 1534-6293
J9 CURR NEUROL NEUROSCI
JI Curr. Neurol. Neurosci. Rep.
PD APR
PY 2012
VL 12
IS 2
BP 218
EP 225
DI 10.1007/s11910-012-0252-0
PG 8
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 912KR
UT WOS:000301797400013
PM 22322663
DA 2025-06-11
ER

PT J
AU Gangopadhyay, A
   Ibrahim, R
   Theberge, K
   May, M
   Houseknecht, KL
AF Gangopadhyay, Anwesha
   Ibrahim, Radwa
   Theberge, Karli
   May, Meghan
   Houseknecht, Karen L. L.
TI Non-alcoholic fatty liver disease (NAFLD) and mental illness: Mechanisms
   linking mood, metabolism and medicines
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Review
DE metabolic liver disease; antipsychotic; insulin resistance;
   inflammation; schizophrenia; depression; obesity; ferroptosis
ID C-REACTIVE PROTEIN; MAJOR DEPRESSIVE DISORDER; TRABECULAR BONE LOSS;
   INSULIN-RESISTANCE; ATYPICAL ANTIPSYCHOTICS; CARDIOVASCULAR-DISEASE;
   HEPATIC STEATOSIS; BIPOLAR DISORDER; NERVOUS-SYSTEM; IRON OVERLOAD
AB Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the world and one of the leading indications for liver transplantation. It is one of the many manifestations of insulin resistance and metabolic syndrome as well as an independent risk factor for cardiovascular disease. There is growing evidence linking the incidence of NAFLD with psychiatric illnesses such as schizophrenia, bipolar disorder and depression mechanistically via genetic, metabolic, inflammatory and environmental factors including smoking and psychiatric medications. Indeed, patients prescribed antipsychotic medications, regardless of diagnosis, have higher incidence of NAFLD than population norms. The mechanistic pharmacology of antipsychotic-associated NAFLD is beginning to emerge. In this review, we aim to discuss the pathophysiology of NAFLD including its risk factors, insulin resistance and systemic inflammation as well as its intersection with psychiatric illnesses.
C1 [Gangopadhyay, Anwesha; Ibrahim, Radwa; Theberge, Karli; May, Meghan; Houseknecht, Karen L. L.] Univ New England, Coll Osteopath Med, Dept Biomed Sci, Biddeford, ME 04005 USA.
C3 University of New England - Maine
RP Houseknecht, KL (corresponding author), Univ New England, Coll Osteopath Med, Dept Biomed Sci, Biddeford, ME 04005 USA.
EM khouseknecht@une.edu
CR Adams LA, 2017, GUT, V66, P1138, DOI 10.1136/gutjnl-2017-313884
   Adzic M, 2013, PSYCHONEUROENDOCRINO, V38, P2914, DOI 10.1016/j.psyneuen.2013.07.019
   Afzal M, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.769309
   Ahmad M, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17197156
   Akyuz U, 2015, SCAND J GASTROENTERO, V50, P341, DOI 10.3109/00365521.2014.983160
   Al-Amin MM, 2013, CLIN PSYCHOPHARM NEU, V11, P144, DOI 10.9758/cpn.2013.11.3.144
   Ala M, 2021, ENDOCRINOLOGY, V162, DOI 10.1210/endocr/bqab157
   Allen J, 2018, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00386
   Allison DB, 2009, AM J PREV MED, V36, P341, DOI 10.1016/j.amepre.2008.11.020
   Altun IK, 2021, J TRACE ELEM MED BIO, V68, DOI 10.1016/j.jtemb.2021.126843
   Alural B, 2017, PROG NEURO-PSYCHOPH, V73, P87, DOI 10.1016/j.pnpbp.2016.03.010
   Amir M, 2020, FRONT MED-LAUSANNE, V7, DOI 10.3389/fmed.2020.00062
   Ananth J, 2001, J PSYCHIATR NEUROSCI, V26, P385
   Anstee QM, 2013, NAT REV GASTRO HEPAT, V10, P330, DOI 10.1038/nrgastro.2013.41
   Anttila V, 2018, SCIENCE, V360, P1313, DOI 10.1126/science.aap8757
   Ayyash A, 2021, CAN J PHYSIOL PHARM, V99, P983, DOI 10.1139/cjpp-2020-0721
   Bacaro V, 2020, OBES RES CLIN PRACT, V14, P301, DOI 10.1016/j.orcp.2020.03.004
   Bajaj M, 2012, DIABETES, V61, P3078, DOI 10.2337/db12-1100
   Baptista-González H, 2005, ARCH MED RES, V36, P142, DOI 10.1016/j.arcmed.2004.12.007
   Baranova A, 2008, HEPATOLOGY, V47, P373, DOI 10.1002/hep.22140
   Beauchemin M, 2020, PHARMACOL RES, V152, DOI 10.1016/j.phrs.2019.104589
   Bedogni G, 2006, BMC GASTROENTEROL, V6, DOI 10.1186/1471-230X-6-33
   Bedrosian TA, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/tp.2016.262
   Berke JD, 2018, NAT NEUROSCI, V21, P787, DOI 10.1038/s41593-018-0152-y
   Bernhardt Philipp, 2018, BMC Res Notes, V11, P101, DOI 10.1186/s13104-018-3212-1
   Beurel E, 2020, NEURON, V107, P234, DOI 10.1016/j.neuron.2020.06.002
   Bicker J, 2020, BRIT J PHARMACOL, V177, P2215, DOI 10.1111/bph.15017
   Bjorklund G, 2020, MOL NEUROBIOL, V57, P2314, DOI 10.1007/s12035-019-01742-2
   Browning JD, 2004, HEPATOLOGY, V40, P1387, DOI 10.1002/hep.20466
   Brunt EM, 2015, NAT REV DIS PRIMERS, V1, DOI 10.1038/nrdp.2015.80
   Bugge A, 2012, GENE DEV, V26, P657, DOI 10.1101/gad.186858.112
   Burghardt KJ, 2018, PROG NEURO-PSYCHOPH, V83, P55, DOI 10.1016/j.pnpbp.2018.01.004
   Buzzetti E, 2016, METABOLISM, V65, P1038, DOI 10.1016/j.metabol.2015.12.012
   Bymaster FP, 1996, NEUROPSYCHOPHARMACOL, V14, P87, DOI 10.1016/0893-133X(94)00129-N
   Byrne CD, 2020, J HEPATOL, V72, P785, DOI 10.1016/j.jhep.2020.01.013
   Caldwell SH, 1999, J HEPATOL, V31, P430, DOI 10.1016/S0168-8278(99)80033-6
   Candon M, 2021, BMC PSYCHIATRY, V21, DOI 10.1186/s12888-021-03533-3
   Cao B, 2019, J TRACE ELEM MED BIO, V51, P79, DOI 10.1016/j.jtemb.2018.10.009
   Capuzzi E, 2017, NEUROSCI BIOBEHAV R, V77, P122, DOI 10.1016/j.neubiorev.2017.03.003
   Carnagarin R, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22084241
   Carnagarin R, 2019, ANN NY ACAD SCI, V1454, P80, DOI 10.1111/nyas.14217
   Cervantes M, 2022, P NATL ACAD SCI USA, V119, DOI 10.1073/pnas.2117113119
   Chang ML, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21218308
   Chao AM, 2019, CURR PSYCHIAT REP, V21, DOI 10.1007/s11920-019-0990-7
   Chavakis T, 2022, J INNATE IMMUN, V14, P1, DOI 10.1159/000521305
   Chavez CP, 2022, J CLIN ENDOCR METAB, V107, P29, DOI 10.1210/clinem/dgab578
   Cheah WL, 2013, SE ASIAN J TROP MED, V44, P309
   Chen CH, 2006, J CLIN GASTROENTEROL, V40, P745, DOI 10.1097/00004836-200609000-00016
   Chen F, 2020, HEPATOLOGY, V71, P1213, DOI 10.1002/hep.30908
   Chen ML, 2012, INT IMMUNOPHARMACOL, V12, P197, DOI 10.1016/j.intimp.2011.11.011
   Cheon SY, 2022, CELL BIOSCI, V12, DOI 10.1186/s13578-022-00836-0
   Chesney E, 2014, WORLD PSYCHIATRY, V13, P153, DOI 10.1002/wps.20128
   Chitturi Shivakumar, 2003, Curr Gastroenterol Rep, V5, P18, DOI 10.1007/s11894-003-0005-y
   Cho J, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18041892
   Cho MS, 2018, J MICROBIOL, V56, P855, DOI 10.1007/s12275-018-8346-2
   Choi JM, 2021, FRONT MED-LAUSANNE, V7, DOI 10.3389/fmed.2020.585618
   Colognesi M, 2020, BIOMEDICINES, V8, DOI 10.3390/biomedicines8070229
   Correll CU, 2015, JAMA PSYCHIAT, V72, P859, DOI 10.1001/jamapsychiatry.2015.0632
   Cortez-Pinto H, 1999, JAMA-J AM MED ASSOC, V282, P1659, DOI 10.1001/jama.282.17.1659
   Cusi K, 2009, CLIN LIVER DIS, V13, P545, DOI 10.1016/j.cld.2009.07.009
   CUTLER P, 1994, CAN J PSYCHIAT, V39, P8, DOI 10.1177/070674379403900104
   Dabravolski SA, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22094459
   Daumit GL, 2003, J NERV MENT DIS, V191, P799, DOI 10.1097/01.nmd.0000100923.20188.2d
   Davey KJ, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.83
   Davey KJ, 2012, PSYCHOPHARMACOLOGY, V221, P155, DOI 10.1007/s00213-011-2555-2
   Dawes AJ, 2016, JAMA-J AM MED ASSOC, V315, P150, DOI 10.1001/jama.2015.18118
   Dayabandara M, 2017, NEUROPSYCH DIS TREAT, V13, DOI 10.2147/NDT.S113099
   de Bruin TWA, 2004, AM J MED, V116, P847, DOI 10.1016/j.amjmed.2003.12.031
   De Hert M, 2018, DIALOGUES CLIN NEURO, V20, P31, DOI 10.31887/DCNS.2018.20.1/mdehert
   De Iuliis A, 2022, NEURAL REGEN RES, V17, P523, DOI 10.4103/1673-5374.320965
   de Lédinghen V, 2016, J GASTROEN HEPATOL, V31, P848, DOI 10.1111/jgh.13219
   de Leon J, 2012, HUM GENET, V131, P877, DOI 10.1007/s00439-011-1122-6
   DeFronzo RA, 2011, DIABETES CARE, V34, P789, DOI 10.2337/dc11-0064
   Dhaliwal N, 2019, METHODS MOL BIOL, V2011, P531, DOI 10.1007/978-1-4939-9554-7_31
   Dhamija E, 2019, INDIAN J MED RES, V149, P9, DOI 10.4103/ijmr.IJMR_1456_17
   Di Mauro S, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222111905
   Dickerson F, 2018, PSYCHIAT SERV, V69, P147, DOI 10.1176/appi.ps.201700118
   Dijk DJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030037
   Dimas AS, 2014, DIABETES, V63, P2158, DOI 10.2337/db13-0949
   DiStefano JK, 2022, DIABETOL METAB SYNDR, V14, DOI 10.1186/s13098-022-00814-z
   Donnelly MC, 2022, J HEPATOL, V76, P995, DOI 10.1016/j.jhep.2022.02.012
   Dori Netta, 2011, Harefuah, V150, P791
   Moreira MCD, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00234
   Draijer L, 2019, EXPERT REV GASTROENT, V13, P447, DOI 10.1080/17474124.2019.1595589
   Drzyzga L, 2006, BRAIN BEHAV IMMUN, V20, P532, DOI 10.1016/j.bbi.2006.02.002
   El-Mahdy MA, 2021, AM J PHYSIOL-HEART C, V320, pH2112, DOI 10.1152/ajpheart.00997.2020
   Emmerzaal TL, 2021, NEUROSCI BIOBEHAV R, V127, P555, DOI 10.1016/j.neubiorev.2021.05.001
   Erbas O, 2015, METAB BRAIN DIS, V30, P739, DOI 10.1007/s11011-014-9630-4
   Ermakov EA, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/8881770
   Estrada LD, 2019, FRONT AGING NEUROSCI, V11, DOI 10.3389/fnagi.2019.00174
   Feifel D, 1997, J CLIN PSYCHIAT, V58, P74, DOI 10.4088/JCP.v58n0204
   Ferno J, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020571
   Filiou MD, 2019, TRENDS NEUROSCI, V42, P573, DOI 10.1016/j.tins.2019.07.002
   Flowers SA, 2017, PHARMACOTHERAPY, V37, P261, DOI 10.1002/phar.1890
   Fracanzani AL, 2008, HEPATOLOGY, V48, P792, DOI 10.1002/hep.22429
   Furman D, 2019, NAT MED, V25, P1822, DOI 10.1038/s41591-019-0675-0
   Gamaro GD, 2003, NEUROCHEM RES, V28, P1339, DOI 10.1023/A:1024988113978
   Gjorgjieva M, 2019, GUT, V68, P2065, DOI 10.1136/gutjnl-2018-318146
   Golovaty I, 2020, J NUTR, V150, P91, DOI 10.1093/jn/nxz212
   González-Domínguez A, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21155529
   Gracious BL, 2015, J CHILD ADOL PSYCHOP, V25, P602, DOI 10.1089/cap.2015.0007
   Guarino D, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00665
   Guilherme A, 2008, NAT REV MOL CELL BIO, V9, P367, DOI 10.1038/nrm2391
   Hadjihambi A, 2022, ANAL BIOCHEM, V636, DOI 10.1016/j.ab.2021.114387
   Hamabe A, 2011, J GASTROENTEROL, V46, P769, DOI 10.1007/s00535-011-0376-z
   Harrison JN, 2012, J PEDIATR HEALTH CAR, V26, P139, DOI 10.1016/j.pedhc.2011.10.009
   Harte AL, 2010, J INFLAMM-LOND, V7, DOI 10.1186/1476-9255-7-15
   Hassan A, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.9853
   Hatem R, 2022, JMIR RES PROTOC, V11, DOI 10.2196/20168
   Hattar S, 2006, J COMP NEUROL, V497, P326, DOI 10.1002/cne.20970
   Higarza SG, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0223019
   Holt RIG, 2019, CURR DIABETES REP, V19, DOI 10.1007/s11892-019-1220-8
   Holt RIG, 2009, DIABETES OBES METAB, V11, P665, DOI 10.1111/j.1463-1326.2009.01038.x
   Houseknecht KL, 2007, NEUROPSYCHOPHARMACOL, V32, P289, DOI 10.1038/sj.npp.1301209
   Houseknecht Karen L, 2017, J Ment Health Clin Psychol, V1, P9, DOI 10.29245/2578-2959/2018/1.1106
   Huang DIQ, 2021, NAT REV GASTRO HEPAT, V18, P223, DOI 10.1038/s41575-020-00381-6
   Huang DQ, 2021, PSYCHOPHARMACOLOGY, V238, P2543, DOI 10.1007/s00213-021-05878-9
   Hudson CG, 2005, AM J ORTHOPSYCHIAT, V75, P3, DOI 10.1037/0002-9432.75.1.3
   Hui JM, 2004, HEPATOLOGY, V39, P1458, DOI 10.1002/hep.20223
   Iasevoli F, 2020, EXPERT OPIN DRUG SAF, V19, P1419, DOI 10.1080/14740338.2020.1820985
   Ishay Y, 2021, AM J PHYSIOL-GASTR L, V321, pG400, DOI 10.1152/ajpgi.00186.2021
   Islam MR, 2021, EMBO MOL MED, V13, DOI 10.15252/emmm.202013659
   Iwamoto Y, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-199
   Jackson JG, 2015, BIPOLAR DISORD, V17, P575, DOI 10.1111/bdi.12319
   Jadeja RN, 2019, BIOCHEM PHARMACOL, V169, DOI 10.1016/j.bcp.2019.08.015
   Jakobsen AS, 2018, SCHIZOPHR RES, V199, P109, DOI 10.1016/j.schres.2018.03.016
   Jensen KJ, 2013, COMPR PHYSIOL, V3, P655, DOI 10.1002/cphy.c120018
   Jorgensen BP, 2015, PHYSIOL BEHAV, V141, P32, DOI 10.1016/j.physbeh.2014.12.042
   Jung JY, 2019, HEPATOL INT, V13, P222, DOI 10.1007/s12072-018-9892-8
   Kabir MT, 2022, ENVIRON SCI POLLUT R, V29, P46385, DOI 10.1007/s11356-022-20445-1
   Kahl S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094059
   Kang D, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-019-57036-z
   Kang GH, 2011, J MAGN RESON IMAGING, V34, P928, DOI 10.1002/jmri.22701
   Katsarou A, 2020, WORLD J GASTROENTERO, V26, P1993, DOI 10.3748/wjg.v26.i17.1993
   Kawai H, 2019, CHRONOBIOL INT, V36, P1194, DOI 10.1080/07420528.2019.1625360
   Kessoku T, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22158161
   Kim HJ, 2004, ARCH INTERN MED, V164, P2169, DOI 10.1001/archinte.164.19.2169
   Kim NH, 2018, LIVER INT, V38, P1487, DOI 10.1111/liv.13701
   Kim SW, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111707
   Kim YH, 2020, ENDOCR REV, V41, DOI 10.1210/endrev/bnaa014
   Kimura T, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.773432
   Klein MO, 2019, CELL MOL NEUROBIOL, V39, P31, DOI 10.1007/s10571-018-0632-3
   Koch CE, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-16882-6
   Koh WP, 2011, BRIT J CANCER, V105, P1430, DOI 10.1038/bjc.2011.360
   Kotronen A, 2009, GASTROENTEROLOGY, V137, P865, DOI 10.1053/j.gastro.2009.06.005
   Kowalchuk C, 2021, SCHIZOPHR RES, V228, P112, DOI 10.1016/j.schres.2020.12.005
   Kowalchuk C, 2019, PSYCHONEUROENDOCRINO, V104, P42, DOI 10.1016/j.psyneuen.2019.01.029
   Kroeze WK, 2003, NEUROPSYCHOPHARMACOL, V28, P519, DOI 10.1038/sj.npp.1300027
   Kryzhanovskaya LA, 2012, J CHILD ADOL PSYCHOP, V22, P157, DOI 10.1089/cap.2010.0020
   Kullmann S, 2020, LANCET DIABETES ENDO, V8, P524, DOI 10.1016/S2213-8587(20)30113-3
   Kuloglu M, 2003, EUR NEUROPSYCHOPHARM, V13, P67, DOI 10.1016/S0924-977X(02)00073-1
   Kumar R, 2020, J FAM MED PRIM CARE, V9, P390, DOI 10.4103/jfmpc.jfmpc_887_19
   Kunst RF, 2021, JBMR PLUS, V5, DOI 10.1002/jbm4.10541
   Labenz C, 2020, HEPATOL COMMUN, V4, P1293, DOI 10.1002/hep4.1541
   Lamia KA, 2008, P NATL ACAD SCI USA, V105, P15172, DOI 10.1073/pnas.0806717105
   Lavagnino L, 2021, PSYCHIAT RES, V304, DOI 10.1016/j.psychres.2021.114148
   Le Garf S, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9121915
   Le Roy T, 2013, GUT, V62, P1787, DOI 10.1136/gutjnl-2012-303816
   Lebel L, 2022, TRANSCULT PSYCHIATRY, V59, P312, DOI 10.1177/13634615211066698
   Leckman-Westin E, 2018, J MANAG CARE SPEC PH, V24, P238, DOI 10.18553/jmcp.2018.24.3.238
   Lee JH, 2010, DIGEST LIVER DIS, V42, P503, DOI 10.1016/j.dld.2009.08.002
   Lee J, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0172666
   Lee J, 2019, ARCH PHARM RES, V42, P935, DOI 10.1007/s12272-019-01178-1
   Lee YCA, 2009, INT J EPIDEMIOL, V38, P1497, DOI 10.1093/ije/dyp280
   Leng FD, 2021, NAT REV NEUROL, V17, P157, DOI 10.1038/s41582-020-00435-y
   Leung JCF, 2017, HEPATOLOGY, V65, P54, DOI 10.1002/hep.28697
   Li GL, 2012, CLIN HEMORHEOL MICRO, V51, P59, DOI 10.3233/CH-2011-1509
   Li Y, 2014, EUR J GASTROEN HEPAT, V26, P332, DOI 10.1097/MEG.0000000000000015
   Libowitz MR, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.623681
   Lin HY, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9041041
   Liu S, 2019, EXP NEUROL, V320, DOI 10.1016/j.expneurol.2019.113006
   Liu YL, 2014, J HEPATOL, V61, P75, DOI 10.1016/j.jhep.2014.02.030
   Lonardo A, 2020, ANN HEPATOL, V19, P359, DOI 10.1016/j.aohep.2020.03.001
   Lonardo A, 2019, HEPATOLOGY, V70, P1457, DOI 10.1002/hep.30626
   Loomba R, 2020, HEPATOLOGY, V72, P1219, DOI 10.1002/hep.31121
   Loosen SH, 2022, Z GASTROENTEROL, V60, P1221, DOI 10.1055/a-1482-9236
   Lu DY, 2020, DRUG METAB DISPOS, V48, P395, DOI 10.1124/dmd.120.090472
   Maas DA, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/tp.2017.138
   Maddatu J, 2017, TRANSL RES, V184, P101, DOI 10.1016/j.trsl.2017.02.004
   Mahapatra MK, 2022, PHARM RES-DORDR, V39, P1233, DOI 10.1007/s11095-022-03302-1
   Maier S, 2021, REV ENDOCR METAB DIS, V22, P351, DOI 10.1007/s11154-020-09621-1
   Malekizadeh Y, 2020, ALZH DEMENT-TRCI, V6, DOI 10.1002/trc2.12078
   Malik S, 2014, COMPR PSYCHIAT, V55, P248, DOI 10.1016/j.comppsych.2013.08.021
   Manco M, 2011, J HEPATOL, V55, P647, DOI 10.1016/j.jhep.2010.12.007
   Mann JP, 2018, SEMIN LIVER DIS, V38, P1, DOI 10.1055/s-0038-1627456
   Marra F, 2018, J HEPATOL, V68, P280, DOI 10.1016/j.jhep.2017.11.014
   Martins PJF, 2010, DIABETES, V59, P2418, DOI 10.2337/db10-0449
   Martins-de-Souza D, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.13
   Masaki T, 2004, DIABETES, V53, P2250, DOI 10.2337/diabetes.53.9.2250
   May M, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10061225
   May M, 2020, BRAIN BEHAV IMMUN-HL, V6, DOI 10.1016/j.bbih.2020.100097
   May M, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0218937
   Mazereel V, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.573479
   McCutcheon RA, 2019, TRENDS NEUROSCI, V42, P205, DOI 10.1016/j.tins.2018.12.004
   McIntyre RS, 2020, LANCET, V396, P1841, DOI 10.1016/S0140-6736(20)31544-0
   Meng M, 2022, EUR J PEDIATR, V181, P3259, DOI 10.1007/s00431-022-04515-7
   Middleton J, 2020, ENVIRON RES LETT, V15, DOI 10.1088/1748-9326/ab68a9
   Middleton MS, 2017, GASTROENTEROLOGY, V153, P753, DOI 10.1053/j.gastro.2017.06.005
   Mikkelsen ACD, 2024, NEUROCHEM RES, V49, P1468, DOI 10.1007/s11064-022-03551-x
   Minjon L, 2022, J CHILD ADOL PSYCHOP, V32, P36, DOI 10.1089/cap.2021.0026
   Mizuno K, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0249556
   Mohamed AA, 2021, J GENET ENG BIOTECHN, V19, DOI 10.1186/s43141-021-00257-5
   Monahan C, 2022, ANN PHARMACOTHER, V56, P1049, DOI 10.1177/10600280211070330
   Moretti A, 2003, MOL PSYCHIATR, V8, P773, DOI 10.1038/sj.mp.4001353
   Morgan ML, 2016, J GASTROEN HEPATOL, V31, P475, DOI 10.1111/jgh.13085
   Motyl KJ, 2017, BONE, V103, P168, DOI 10.1016/j.bone.2017.07.008
   Motyl KJ, 2015, ENDOCRINOLOGY, V156, P2374, DOI 10.1210/en.2015-1099
   Motyl KJ, 2012, BONE, V50, P490, DOI 10.1016/j.bone.2011.08.005
   Mouzaki M, 2019, J PEDIATR GASTR NUTR, V69, P339, DOI 10.1097/MPG.0000000000002401
   Münzel T, 2020, EUR HEART J, V41, P4057, DOI 10.1093/eurheartj/ehaa460
   Mukherji A, 2020, METABOLISM, V111, DOI 10.1016/j.metabol.2020.154337
   NAGAYAMA H, 1993, PHARMACOL THERAPEUT, V59, P31, DOI 10.1016/0163-7258(93)90040-K
   Nahmias Y, 2021, ANNU REV BIOMED ENG, V23, P203, DOI 10.1146/annurev-bioeng-082120-034725
   Ndumele CE, 2011, ARTERIOSCL THROM VAS, V31, P1927, DOI 10.1161/ATVBAHA.111.228262
   Nelson JE, 2007, HEPATOLOGY, V46, P723, DOI 10.1002/hep.21742
   Nijman RG, 2015, PEDIATR EMERG CARE, V31, P633, DOI 10.1097/PEC.0000000000000466
   Nijman RG, 2014, PEDIATR INFECT DIS J, V33, pE273, DOI 10.1097/INF.0000000000000466
   Niture S, 2018, CELL COMMUN SIGNAL, V16, DOI 10.1186/s12964-018-0282-6
   Nobili V, 2019, NAT REV GASTRO HEPAT, V16, P517, DOI 10.1038/s41575-019-0169-z
   Oh KJ, 2011, AM J PHYSIOL-ENDOC M, V300, pE24, DOI 10.1152/ajpendo.00502.2010
   Okamoto M, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0195147
   Olaciregui I, 2009, ARCH DIS CHILD, V94, P501, DOI 10.1136/adc.2008.146530
   Owiredu WKBA, 2019, BMC RES NOTES, V12, DOI 10.1186/s13104-019-4847-2
   Paik JM, 2019, HEPATOL COMMUN, V3, P1459, DOI 10.1002/hep4.1419
   Park J, 2021, ENDOCRINOL METAB, V36, P1151, DOI 10.3803/EnM.2021.1331
   Pedersen CB, 2014, JAMA PSYCHIAT, V71, P573, DOI 10.1001/jamapsychiatry.2014.16
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Perakakis N, 2020, METABOLISM, V111, DOI 10.1016/j.metabol.2020.154320
   Persico AM, 2021, PROG NEURO-PSYCHOPH, V110, DOI 10.1016/j.pnpbp.2021.110326
   Piazzolla VA, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9041005
   Pirola CJ, 2015, HEPATOLOGY, V62, P1742, DOI 10.1002/hep.28142
   Plana-Ripoll O, 2019, LANCET, V394, P1827, DOI 10.1016/S0140-6736(19)32316-5
   Polyzos SA, 2019, METABOLISM, V92, P82, DOI 10.1016/j.metabol.2018.11.014
   Prokkola JM, 2018, J EXP BIOL, V221, DOI 10.1242/jeb.179267
   Raeder MB, 2006, MOL CELL BIOCHEM, V289, P167, DOI 10.1007/s11010-006-9160-4
   Rajan TM, 2017, J POSTGRAD MED, V63, P182, DOI 10.4103/jpgm.JPGM_712_16
   Rajesh Y, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22042163
   Raveendran VV, 2014, AM J PHYSIOL-GASTR L, V307, pG219, DOI 10.1152/ajpgi.00027.2014
   Resende R, 2020, BBA-MOL BASIS DIS, V1866, DOI 10.1016/j.bbadis.2020.165752
   Riazi K, 2022, LANCET GASTROENTEROL, V7, P851, DOI 10.1016/S2468-1253(22)00165-0
   Richelson E, 2000, LIFE SCI, V68, P29, DOI 10.1016/S0024-3205(00)00911-5
   Romeo B, 2018, INT J NEUROPSYCHOPH, V21, P828, DOI 10.1093/ijnp/pyy062
   Rosato V, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16183415
   Rosenblat JD, 2017, BRAIN SCI, V7, DOI 10.3390/brainsci7110144
   Rostama B, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21249362
   Roy B, 2020, MOL DIAGN THER, V24, P279, DOI 10.1007/s40291-020-00464-9
   Roy-Byrne PP, 2009, PSYCHIAT SERV, V60, P1190, DOI 10.1176/ps.2009.60.9.1190
   Ruben MD, 2019, SCIENCE, V365, P547, DOI 10.1126/science.aax7621
   Rubí B, 2010, ENDOCRINOLOGY, V151, P5570, DOI 10.1210/en.2010-0745
   Rus SG, 2022, SCHIZOPHR RES, V246, P30, DOI 10.1016/j.schres.2022.06.001
   Russo B, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22105187
   Saad M, 2020, CHILDREN-BASEL, V7, DOI 10.3390/children7120305
   Safari Z, 2019, CELL MOL LIFE SCI, V76, P1541, DOI 10.1007/s00018-019-03011-w
   Samet JM, 2013, THORAC SURG CLIN, V23, P103, DOI 10.1016/j.thorsurg.2013.01.009
   Samuel VT, 2018, CELL METAB, V27, P22, DOI 10.1016/j.cmet.2017.08.002
   Santos IS, 2012, EMERG MED J, V29, P965, DOI 10.1136/emermed-2011-200787
   Sanyal AJ, 2001, GASTROENTEROLOGY, V120, P1183, DOI 10.1053/gast.2001.23256
   Saran AR, 2020, GASTROENTEROLOGY, V158, P1948, DOI 10.1053/j.gastro.2020.01.050
   Sarma S, 2021, DIABETES OBES METAB, V23, P3, DOI 10.1111/dom.14290
   Savoy YE, 2010, SCHIZOPHRENIA BULL, V36, P410, DOI 10.1093/schbul/sbn104
   Schuld A, 2004, NERVENARZT, V75, P215, DOI 10.1007/s00115-003-1599-x
   Schwartz WJ, 2019, NEUROL CLIN, V37, P475, DOI 10.1016/j.ncl.2019.03.001
   Schwarz E, 2018, SCHIZOPHR RES, V192, P398, DOI 10.1016/j.schres.2017.04.017
   Shaunak M, 2021, ARCH DIS CHILD, V106, P3, DOI 10.1136/archdischild-2019-318063
   Shea S, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9111697
   Shedlock K, 2016, J PEDIATR-US, V178, P183, DOI 10.1016/j.jpeds.2016.07.055
   Siafis S, 2018, CURR NEUROPHARMACOL, V16, P1210, DOI 10.2174/1570159X15666170630163616
   Sinakos E, 2022, ANN GASTROENTEROL, V35, P213, DOI 10.20524/aog.2022.0704
   Skonieczna-Zydecka K, 2019, PSYCHOPHARMACOLOGY, V236, P1491, DOI 10.1007/s00213-018-5102-6
   Smith GI, 2020, J CLIN INVEST, V130, P1453, DOI 10.1172/JCI134165
   Sodum N, 2021, PHARMACOL RES, V167, DOI 10.1016/j.phrs.2021.105484
   Sohn M, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000003784
   Solas M, 2017, CURR OPIN PHARMACOL, V37, P87, DOI 10.1016/j.coph.2017.10.005
   Sookoian S, 2017, CLIN MOL HEPATOL, V23, P1, DOI 10.3350/cmh.2016.0109
   Soto-Angona O, 2020, BMC MED, V18, DOI 10.1186/s12916-020-01713-8
   Srivastava A, 2021, PSYCHIAT RES, V305, DOI 10.1016/j.psychres.2021.114218
   Stasi C, 2019, CURR DRUG METAB, V20, P646, DOI 10.2174/1389200220666190725115503
   Stenvers DJ, 2019, NAT REV ENDOCRINOL, V15, P75, DOI 10.1038/s41574-018-0122-1
   Stoelzel CR, 2020, ENDOCRIN DIAB METAB, V3, DOI 10.1002/edm2.139
   Stogios N, 2021, NPJ SCHIZOPHR, V7, DOI 10.1038/s41537-021-00151-6
   Streck EL, 2014, REV BRAS PSIQUIATR, V36, P156, DOI 10.1590/1516-4446-2013-1224
   Sunny NE, 2017, TRENDS ENDOCRIN MET, V28, P250, DOI 10.1016/j.tem.2016.11.006
   Sykes DA, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00716-z
   Szabo G, 2021, HEPATOLOGY, V74, P5, DOI 10.1002/hep.31805
   Takahashi JS, 2017, NAT REV GENET, V18, P164, DOI 10.1038/nrg.2016.150
   Talens M, 2021, J CLIN MED, V10, DOI 10.3390/jcm10215019
   Tang A, 2013, RADIOLOGY, V267, P422, DOI 10.1148/radiol.12120896
   Targher G, 2021, NAT REV GASTRO HEPAT, V18, P599, DOI 10.1038/s41575-021-00448-y
   Tomeno W, 2015, J GASTROEN HEPATOL, V30, P1009, DOI 10.1111/jgh.12897
   Troubat R, 2021, EUR J NEUROSCI, V53, P151, DOI 10.1111/ejn.14720
   Tsermpini EE, 2022, PHARMACOGENOMICS J, V22, P211, DOI 10.1038/s41397-022-00283-7
   Tsurusaki S, 2019, CELL DEATH DIS, V10, DOI 10.1038/s41419-019-1678-y
   Vadnie CA, 2017, NEURAL PLAST, V2017, DOI 10.1155/2017/1504507
   Vancampfort D, 2017, WORLD PSYCHIATRY, V16, P308, DOI 10.1002/wps.20458
   Vancampfort D, 2016, J AFFECT DISORDERS, V201, P145, DOI 10.1016/j.jad.2016.05.020
   Vehof J, 2011, PSYCHOPHARMACOLOGY, V216, P257, DOI 10.1007/s00213-011-2211-x
   Ventura T, 2014, NUTRITION, V30, P252, DOI 10.1016/j.nut.2013.06.010
   Vigo D, 2016, LANCET PSYCHIAT, V3, P171, DOI 10.1016/S2215-0366(15)00505-2
   Villa RF, 2017, NEUROPHARMACOLOGY, V121, P30, DOI 10.1016/j.neuropharm.2017.04.025
   Villa RF, 2016, NEUROSCIENCE, V330, P326, DOI 10.1016/j.neuroscience.2016.05.051
   Walton JC, 2021, CLIN PHARMACOL THER, V109, P1457, DOI 10.1002/cpt.2073
   Willi C, 2007, JAMA-J AM MED ASSOC, V298, P2654, DOI 10.1001/jama.298.22.2654
   Wu J, 2021, CELL DEATH DISCOV, V7, DOI 10.1038/s41420-021-00660-4
   Xu L, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20235920
   Xu T, 2017, METAB BRAIN DIS, V32, P483, DOI 10.1007/s11011-016-9941-8
   Ye Q, 2020, LANCET GASTROENTEROL, V5, P739, DOI 10.1016/S2468-1253(20)30077-7
   Younossi ZM, 2015, HEPATOLOGY, V62, p739A, DOI 10.1002/hep.28431
   Youssef NA, 2013, LIVER INT, V33, P1062, DOI 10.1111/liv.12165
   Yu Elizabeth L, 2021, Clin Liver Dis (Hoboken), V17, P196, DOI 10.1002/cld.1027
   Yu TY, 2021, J DIABETES INVEST, V12, P2108, DOI 10.1111/jdi.13691
   Zarrinpar A, 2016, GUT, V65, P1546, DOI 10.1136/gutjnl-2015-309456
   Zeng CR, 2021, PROG NEURO-PSYCHOPH, V106, DOI 10.1016/j.pnpbp.2020.110097
   Zhang R, 2014, P NATL ACAD SCI USA, V111, P16219, DOI 10.1073/pnas.1408886111
   Zheng P, 2019, SCI ADV, V5, DOI 10.1126/sciadv.aau8317
   Zhu LX, 2013, HEPATOLOGY, V57, P601, DOI 10.1002/hep.26093
NR 315
TC 14
Z9 14
U1 1
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD NOV 15
PY 2022
VL 16
AR 1042442
DI 10.3389/fnins.2022.1042442
PG 24
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 6Q3DQ
UT WOS:000891495600001
PM 36458039
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Filia, SL
   Baker, AL
   Kulkarni, J
   Williams, JM
AF Filia, Sacha L.
   Baker, Amanda L.
   Kulkarni, Jayashri
   Williams, Jill M.
TI Sequential behavioral treatment of smoking and weight control in bipolar
   disorder
SO TRANSLATIONAL BEHAVIORAL MEDICINE
LA English
DT Article
DE Smoking; Smoking cessation; Bipolar disorder; Sequential behavioral
   treatment; Weight gain; Physical activity
ID RANDOMIZED CONTROLLED-TRIAL; HEART-DISEASE RISK; SEVERE MENTAL-ILLNESS;
   SUBSTANCE USE; TOBACCO DEPENDENCE; PSYCHOTIC DISORDER; METABOLIC
   SYNDROME; MOOD DISORDERS; CESSATION; PEOPLE
AB People with severe mental illnesses like schizophrenia and bipolar disorder (BPAD) live significantly shorter lives than people in the general population and most commonly die of cardiovascular disease (CVD). CVD risk behaviors such as smoking are not routinely assessed or assertively treated among people with a severe mental illness. This article provides an illustrative case example of a woman with BPAD who is motivated to quit smoking, despite concerns about weight gain and relapse to depression. It outlines key considerations and describes the patient's experience of participating in a behavioral intervention focussing first on smoking, then diet and physical activity. Clinical challenges encountered during treatment are discussed in the context of relevant literature. These include motivational issues, relapse to depression, medication interactions, weight gain, addressing multiple health behavior change, focussing on a behavioral rather than cognitive approach, collaborating with other health care providers, and gender issues.
C1 [Filia, Sacha L.; Kulkarni, Jayashri] Monash Univ, Monash Alfred Psychiat Res Ctr, Alfred Hosp, Prahran, Vic 3181, Australia.
   [Baker, Amanda L.] Univ Newcastle, Ctr Brain & Mental Hlth Res, Newcastle, NSW 2300, Australia.
   [Williams, Jill M.] UMDNJ Robert Wood Johnson Med Sch, Div Addict Psychiat, New Brunswick, NJ USA.
C3 Florey Institute of Neuroscience & Mental Health; Howard Florey
   Institute Affiliates; Monash University; University of Newcastle;
   Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences
RP Filia, SL (corresponding author), Monash Univ, Monash Alfred Psychiat Res Ctr, Alfred Hosp, Level 1,Old Baker Bldg,POB 315, Prahran, Vic 3181, Australia.
EM s.filia@alfred.org.au
RI Baker, Amanda/H-2966-2014
OI Filia, Sacha/0009-0001-1335-0216; Baker, Amanda L./0000-0002-3328-7146
FU Australian National Health and Medical Research Council (NHMRC)
FX Funding for the randomized controlled smoking cessation trial was
   provided by the Australian National Health and Medical Research Council
   (NHMRC), while GlaxoSmithKline provided NRT for the study. Thank you to
   Dr. Kate Hoy and Dr. Stuart Lee for support in preparation of this
   manuscript.
CR Angst F, 2002, J AFFECT DISORDERS, V68, P167, DOI 10.1016/S0165-0327(01)00377-9
   [Anonymous], TREATING TOBACCO USE
   [Anonymous], 2010, AIHW CAT AUS 122
   [Anonymous], 2011, MENT HLTH SUBST USE, DOI DOI 10.1080/17523281.2011.555088
   [Anonymous], 2009, Motivational interviewing: Preparing people for change
   Baker A, 2002, ADDICTION, V97, P1329, DOI 10.1046/j.1360-0443.2002.00178.x
   Baker A.L., 2011, Mental Health and Substance Use, V4, P144, DOI [DOI 10.1080/17523281.2011.555086, DOI 10.1080/17523281.2011.5]
   Baker AL., 2010, PRIMARY PSYCHIAT, V17, P49
   Baker A, 2007, PSYCHIAT RES, V150, P141, DOI 10.1016/j.psychres.2006.05.021
   Baker A, 2006, AM J PSYCHIAT, V163, P1934, DOI 10.1176/appi.ajp.163.11.1934
   Baker A, 2006, BRIT J PSYCHIAT, V188, P439, DOI 10.1192/bjp.188.5.439
   Baker A, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-10
   Baker A, 2009, AUST NZ J PSYCHIAT, V43, P129, DOI 10.1080/00048670802607147
   Banham L, 2010, ADDICTION, V105, P1176, DOI 10.1111/j.1360-0443.2010.02946.x
   Barrowclough C, 2001, AM J PSYCHIAT, V158, P1706, DOI 10.1176/appi.ajp.158.10.1706
   Berk M, 2008, J AFFECT DISORDERS, V110, P126, DOI 10.1016/j.jad.2008.01.018
   Berlin I, 2009, CURR MED RES OPIN, V25, P527, DOI 10.1185/03007990802707626
   Birkenaes AB, 2007, J CLIN PSYCHIAT, V68, P917, DOI 10.4088/JCP.v68n0614
   Bresee LC, 2010, SCHIZOPHR RES, V117, P75, DOI 10.1016/j.schres.2009.12.016
   Campion J., 2008, Advances in Psychiatric Treatment, V14, P208, DOI DOI 10.1192/apt.bp.107.003483
   Colton Craig W, 2006, Prev Chronic Dis, V3, pA42
   Correll CU, 2008, BIPOLAR DISORD, V10, P788, DOI 10.1111/j.1399-5618.2008.00625.x
   Daumit GL, 2008, SCHIZOPHR RES, V105, P175, DOI 10.1016/j.schres.2008.07.006
   Diaz FJ, 2009, BIPOLAR DISORD, V11, P154, DOI 10.1111/j.1399-5618.2009.00664.x
   Dodd S, 2010, COMPR PSYCHIAT, V51, P504, DOI 10.1016/j.comppsych.2009.12.001
   Druss BG, 1998, AM J PSYCHIAT, V155, P1775, DOI 10.1176/ajp.155.12.1775
   el-Guebaly N, 2002, PSYCHIATR SERV, V53, P1166, DOI 10.1176/appi.ps.53.9.1166
   Els C, 2008, SMOKING CESSATION RO, P2
   Fagerström K, 2009, CURR MED RES OPIN, V25, P511, DOI [10.1185/03007990802707568, 10.1185/03007990802707568 ]
   Fagiolini A, 2004, J CLIN PSYCHIAT, V65, P509
   Fagiolini A, 2003, AM J PSYCHIAT, V160, P112, DOI 10.1176/appi.ajp.160.1.112
   Filia SL, 2008, AUST NZ J PSYCHIAT, V42, pA61
   Filia SL, 2010, AUSTR SOC PSYCH RES
   Foulds J, 2006, DRUG ALCOHOL REV, V25, P59, DOI 10.1080/09595230500459529
   Garcia-Portilla MP, 2009, J AFFECT DISORDERS, V115, P302, DOI 10.1016/j.jad.2008.09.008
   Hennekens CH, 2007, J CLIN PSYCHIAT, V68, P4
   Hughes J R, 1999, Nicotine Tob Res, V1, P169, DOI 10.1080/14622299050011281
   Hughes JR, 2007, NICOTINE TOB RES, V9, P443, DOI 10.1080/14622200701243185
   Hyman DJ, 2007, ARCH INTERN MED, V167, P1152, DOI 10.1001/archinte.167.11.1152
   Kupfer DJ, 2005, JAMA-J AM MED ASSOC, V293, P2528, DOI 10.1001/jama.293.20.2528
   Lasser K, 2000, JAMA-J AM MED ASSOC, V284, P2606, DOI 10.1001/jama.284.20.2606
   Martino S, 2006, ADDICTION, V101, P1479, DOI 10.1111/j.1360-0443.2006.01554.x
   McElroy SL, 2004, J CLIN PSYCHIAT, V65, P634
   McKee SA, 2005, ADDICT BEHAV, V30, P423, DOI 10.1016/j.addbeh.2004.05.027
   McNeil JJ, 2010, CARDIOVASC DRUG THER, V24, P359, DOI 10.1007/s10557-010-6246-8
   Miller BJ, 2006, PSYCHIAT SERV, V57, P1482, DOI 10.1176/appi.ps.57.10.1482
   Morrison KN, 2010, J ADDICT NURS, V21, P79, DOI 10.3109/10884602.2010.481505
   Newcomer JW, 2007, AM J MANAG CARE, V13, pS170
   Osborn DPJ, 2007, SOC PSYCH PSYCH EPID, V42, P787, DOI 10.1007/s00127-007-0247-3
   Perkins KA, 2001, CNS DRUGS, V15, P391, DOI 10.2165/00023210-200115050-00005
   Siru R, 2009, ADDICTION, V104, P719, DOI 10.1111/j.1360-0443.2009.02545.x
   Spring B, 2004, J CONSULT CLIN PSYCH, V72, P785, DOI 10.1037/0022-006X.72.5.785
   Sweeney CT, 2001, CNS DRUGS, V15, P453, DOI 10.2165/00023210-200115060-00004
   Torrent C, 2008, ACTA PSYCHIAT SCAND, V118, P4, DOI 10.1111/j.1600-0447.2008.01204.x
   Vanable PA, 2003, PSYCHOL ADDICT BEHAV, V17, P259, DOI 10.1037/0893-164X.17.4.259
   Virk S, 2004, Obes Rev, V5, P167, DOI 10.1111/j.1467-789X.2004.00141.x
   Waxmonsky JA, 2005, GEN HOSP PSYCHIAT, V27, P321, DOI 10.1016/j.genhosppsych.2005.05.003
   Williams JM, 2007, AM J PSYCHIAT, V164, P222, DOI 10.1176/appi.ajp.164.2.222
   Williams JM, 2011, ADM POLICY MENT HLTH, V38, P368, DOI 10.1007/s10488-010-0324-x
   Williams JM, 2003, PSYCHIAT ANN, V33, P457, DOI 10.3928/0048-5713-20030701-07
   Wye P, 2010, J PSYCHIATR MENT HLT, V17, P319, DOI 10.1111/j.1365-2850.2009.01524.x
   Zevin S, 1999, CLIN PHARMACOKINET, V36, P425, DOI 10.2165/00003088-199936060-00004
NR 62
TC 7
Z9 7
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1869-6716
EI 1613-9860
J9 TRANSL BEHAV MED
JI Transl. Behav. Med.
PD SEP
PY 2012
VL 2
IS 3
BP 290
EP 295
DI 10.1007/s13142-012-0111-1
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA V39LM
UT WOS:000209412500009
PM 24073127
OA Green Published
DA 2025-06-11
ER

PT J
AU Abboud, M
   Haidar, S
   Mahboub, N
   Mamo, T
   Papandreou, D
   Rizk, R
AF Abboud, Myriam
   Haidar, Suzan
   Mahboub, Nadine
   Mamo, Tracy
   Papandreou, Dimitrios
   Rizk, Rana
TI Association between the metabolic syndrome and the irritable bowel
   syndrome: a cross-sectional study among a sample of Lebanese adults
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article; Early Access
DE Metabolic Syndrome; Irritable Bowel Syndrome; Lebanon; Adults
ID SLEEP QUALITY INDEX; PERCEIVED STRESS; DEFINITION; PREVALENCE;
   EPIDEMIOLOGY; AXIS
AB Evidence of an association between metabolic syndrome (MetS) and irritable bowel syndrome (IBS) is emerging but is still inconclusive. The current cross-sectional study was conducted to explore the relationship between the two syndromes in a sample of Lebanese adults (n 221; mean age: 43<middle dot>36 years; 62<middle dot>9 % females), recruited from a large urban university and its neighbouring community. MetS was diagnosed based on the International Diabetes Federation criteria, and IBS was assessed using the Birmingham IBS scale. Logistic regression analyses were performed taking MetS and its components as dependent variables and IBS and its subscales as independent variables. Covariates included socio-demographic, dietary and lifestyle variables. MetS was positively associated with visual analogue scale (VAS) IBS (total scale (Beta = 4<middle dot>59, P = 0<middle dot>029) and VAS-diarrhoea subscale (Beta = 4<middle dot>96, P = 0<middle dot>008). Elevated blood pressure (Beta = 5<middle dot>02, P = 0<middle dot>007), elevated fasting blood sugar (Beta = 4<middle dot>19, P = 0<middle dot>033) and elevated waist circumference (Beta = 5<middle dot>38, P = 0<middle dot>010) were positively associated with VAS-Diarrhoea subscale. MetS and IBS were found to be positively associated in a sample of the Lebanese adult population. We suggest that it might be of value to screen for either condition if one of the syndromes exists. Future longitudinal studies are essential to establish a causal relationship between the two syndromes to further understand the commonality related to pathogenesis and explore potential underlying mechanisms.
C1 [Abboud, Myriam] Zayed Univ, Coll Nat & Hlth Sci, Dubai, U Arab Emirates.
   [Haidar, Suzan; Mahboub, Nadine] Lebanese Int Univ, Dept Nutr & Food Sci, Beirut, Lebanon.
   [Mamo, Tracy; Rizk, Rana] Lebanese Amer Univ, Dept Nat Sci, Byblos, Lebanon.
   [Papandreou, Dimitrios] Univ Sharjah, Dept Clin Nutr & Dietet, CHS, Sharjah, U Arab Emirates.
   [Rizk, Rana] Inst Natl Sante Publ Epidemiol Clin & Toxicol INSP, Beirut, Lebanon.
C3 Zayed University; Lebanese American University; University of Sharjah
RP Haidar, S (corresponding author), Lebanese Int Univ, Dept Nutr & Food Sci, Beirut, Lebanon.
EM suzan.haidar@liu.edu.lb
RI Haidar, Suzan/AAC-6895-2020; Rizk, Rana/KLZ-6274-2024
OI Rizk, Rana/0000-0002-8850-6502
FU RIF Grant [R18030]
FX This research was funded the RIF Grant R18030.
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Almansour O, 2024, CUREUS J MED SCIENCE, V16, DOI 10.7759/cureus.65421
   Martínez-González MA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043134
   [Anonymous], 2009, Process of translation and adaptation of instruments
   Bayrak M, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000020577
   Bekar C, 2023, CLIN NUTR ESPEN, V53, P238, DOI 10.1016/j.clnesp.2022.12.026
   BENDEL RB, 1977, J AM STAT ASSOC, V72, P46, DOI 10.2307/2286904
   Boeckxstaens GE, 2016, NEUROGASTROENT MOTIL, V28, P1134, DOI 10.1111/nmo.12886
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1016/0165-1781(89)90047-4
   Carabotti M, 2015, ANN GASTROENTEROL, V28, P203
   Chaaya M, 2010, BMC PSYCHIATRY, V10, DOI 10.1186/1471-244X-10-111
   Chen EY, 2024, CLIN GASTROENTEROL H, V22, P164, DOI 10.1016/j.cgh.2023.07.012
   COHEN J, 1990, AM PSYCHOL, V45, P1304, DOI 10.1037/0003-066X.45.12.1304
   Cohen S., 1998, The social psychology of health, P31
   Costanian C, 2015, WORLD J GASTROENTERO, V21, P3628, DOI 10.3748/wjg.v21.i12.3628
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   Deepa M, 2007, DIABETES-METAB RES, V23, P127, DOI 10.1002/dmrr.658
   Fasano A, 2012, ANN NY ACAD SCI, V1258, P25, DOI 10.1111/j.1749-6632.2012.06538.x
   Fu XY, 2014, NUTR METAB, V11, DOI 10.1186/1743-7075-11-3
   García-Conesa MT, 2020, NUTRIENTS, V12, DOI 10.3390/nu12102960
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Guo YT, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0112289
   Haas JS, 2004, MED CARE, V42, P707, DOI 10.1097/01.mlr.0000129906.95881.83
   Haidar Suzan A, 2018, Open Access Maced J Med Sci, V6, P2214, DOI 10.3889/oamjms.2018.431
   Helou K, 2017, BMC PUBLIC HEALTH, V18, DOI 10.1186/s12889-017-4599-7
   Horwitz BJ, 2001, NEW ENGL J MED, V344, P1846, DOI 10.1056/NEJM200106143442407
   Hyun CK, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22179139
   Javadekar NS, 2021, JGH OPEN, V5, P1148, DOI 10.1002/jgh3.12639
   Jones MP, 2009, PSYCHOL HEALTH MED, V14, P367, DOI 10.1080/13548500902865956
   Kim YS, 2018, J NEUROGASTROENTEROL, V24, P544
   Kumar P., 2022, Pak J Med Health Sci, V16, P1135
   Laaksonen DE, 2004, ANN MED, V36, P332, DOI 10.1080/07853890410031849
   Lakens D, 2013, FRONT PSYCHOL, V4, DOI 10.3389/fpsyg.2013.00863
   Lee CG, 2015, AM J GASTROENTEROL, V110, P310, DOI 10.1038/ajg.2014.422
   Lee EH, 2012, ASIAN NURS RES, V6, P121, DOI 10.1016/j.anr.2012.08.004
   Lee SH, 2016, YONSEI MED J, V57, P146, DOI 10.3349/ymj.2016.57.1.146
   Lovell RM, 2012, CLIN GASTROENTEROL H, V10, P712, DOI 10.1016/j.cgh.2012.02.029
   Mainuddin AKM., 2013, Cardiovasc J, V6, P17, DOI [10.3329/cardio.v6i1.16110, DOI 10.3329/CARDIO.V6I1.16110]
   Mearin F, 2016, REV ESP ENFERM DIG, V108, P57
   MICKEY RM, 1989, AM J EPIDEMIOL, V129, P125, DOI 10.1093/oxfordjournals.aje.a115101
   Montelongo-Rodríguez K, 2019, METAB SYNDR RELAT D, V17, P411, DOI 10.1089/met.2019.0003
   Nilholm C, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071662
   Saad MAN, 2014, ARQ BRAS CARDIOL, V102, P263, DOI 10.5935/abc.20140013
   Nozu T, 2022, J NEUROGASTROENTEROL, V28, P173, DOI 10.5056/jnm21002
   Ohlsson B, 2021, MOL MED REP, V24, DOI 10.3892/mmr.2021.12372
   Poroyko VA, 2016, SCI REP-UK, V6, DOI 10.1038/srep35405
   Posserud I, 2007, GUT, V56, P802, DOI 10.1136/gut.2006.108712
   Quigley EMM, 2006, DIGEST LIVER DIS, V38, P717, DOI 10.1016/j.dld.2006.05.009
   Roalfe AK, 2008, BMC GASTROENTEROL, V8, DOI 10.1186/1471-230X-8-30
   Roberti JW, 2006, J COLL COUNS, V9, P135, DOI 10.1002/j.2161-1882.2006.tb00100.x
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Saidi K, 2021, NUTR RES, V86, P23, DOI 10.1016/j.nutres.2020.12.001
   Santisteban MM, 2017, CIRC RES, V120, P312, DOI 10.1161/CIRCRESAHA.116.309006
   Sibai Abla-Mehio, 2008, CVD Prevention and Control, V3, P83, DOI 10.1016/j.precon.2007.06.002
   Sibai AM, 2001, J EPIDEMIOL COMMUN H, V55, P271, DOI 10.1136/jech.55.4.271
   Singh R, 2021, J NEUROGASTROENTEROL, V27, P19
   Sliem Hamdy Ahmed, 2012, Indian J Endocrinol Metab, V16, P67, DOI 10.4103/2230-8210.91193
   Suleiman KH, 2010, WESTERN J NURS RES, V32, P250, DOI 10.1177/0193945909348230
   Talley NJ, 1999, BEST PRACT RES CL GA, V13, P371, DOI 10.1053/bega.1999.0033
   Tobaldini E, 2017, NEUROSCI BIOBEHAV R, V74, P321, DOI 10.1016/j.neubiorev.2016.07.004
   Vgontzas AN, 2002, ENDOCRIN METAB CLIN, V31, P15, DOI 10.1016/S0889-8529(01)00005-6
   Vila AV, 2018, SCI TRANSL MED, V10, DOI 10.1126/scitranslmed.aap8914
   Wang Z., 2022, Res Square, DOI [10.21203/rs.3.rs-2156939/v1, DOI 10.21203/RS.3.RS-2156939/V1]
   Weaver KR, 2018, BIOL RES NURS, V20, P312, DOI 10.1177/1099800418756733
   Xing JH, 2004, OBES RES, V12, P1723, DOI 10.1038/oby.2004.213
   Yazbeck G, 2023, BMC PUBLIC HEALTH, V23, DOI 10.1186/s12889-023-16543-5
   Zietek T, 2016, FRONT IMMUNOL, V7, DOI 10.3389/fimmu.2016.00154
   Zimmet P, 2005, REV ESP CARDIOL, V58, P1371, DOI 10.1016/S1885-5857(06)60742-1
NR 68
TC 0
Z9 0
U1 1
U2 1
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD 2025 MAR 28
PY 2025
DI 10.1017/S0007114525000650
EA MAR 2025
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1XH9F
UT WOS:001475865300001
PM 40152006
DA 2025-06-11
ER

PT J
AU Vasudevan, SK
   Seetharam, S
   Dohnalek, MH
   Cartwright, EJ
AF Vasudevan, Subbu Kesavaraja
   Seetharam, Suresh
   Dohnalek, Margaret H.
   Cartwright, Elizabeth J.
TI Spirulina: A daily support to our immune system
SO INTERNATIONAL JOURNAL OF NONCOMMUNICABLE DISEASES
LA English
DT Article
DE Algal proteins; amino acids; antioxidants; Arthrospira platensis;
   bioactive; chronic disease; digestion; gut health; immune system;
   metabolic syndrome; microbiome; peptides; spirulina
ID HERPES-SIMPLEX VIRUS; C-PHYCOCYANIN; ANTIOXIDANT; MAXIMA
AB In recent years, the various health benefits of Cyanobacteria microalgae - such as Arthrospira platensis, commonly called Spirulina, an edible blue-green algae - have attracted scientific attention including micro-level examinations of its bioactive components. As a whole food and nutritional supplement, it serves as a plant protein source, which has shown positive effects across a wide range of human health concerns, from malnutrition to metabolic syndrome. Spirulina bioactives, such as essential amino acids, phycocyanin, polysaccharides, carotenoids, and chlorophyll, and essential vitamins and trace minerals, are responsible for its holistic actions against oxidative stress and inflammation, and its antiviral, antibacterial, and immune-modulating effects. Various in vitro, in vivo, and ex vivo experiments have established Spirulina's mechanism of action and its effect on immunity as a proof of concept. The phenolic compounds and extracellular metabolites released from Spirulina whole food after digestion are postulated to strengthen the epithelial lining with antibacterial effects against pathogenic bacteria, adding to its prebiotic effect on the gut microbiota (like Bifidobacterium and Lactobacillus) due to its fiber content. In this study, the digestibility of Spirulina was assessed by the determination of free amino acids and peptide release during the each phase of digestion in a simulated static digestive model system. The hypothesis bridging poor gut health to low-level inflammation and metabolic syndrome, and the potential to address those issues with nutritional supplementation, such as with Spirulina, could also be beneficial in the long run to reduce comorbid illnesses, such as those associated with the currently prevailing coronavirus disease 2019 pandemic.
C1 [Vasudevan, Subbu Kesavaraja] EID Parry Ind Ltd, Dept Med Affairs, Parry Nutraceut, Chennai, Tamil Nadu, India.
   [Seetharam, Suresh] EID Parry Ind Ltd, Dept Res & Dev, Parry Nutraceut, Chennai, Tamil Nadu, India.
   [Dohnalek, Margaret H.; Cartwright, Elizabeth J.] US Nutraceut Inc, Valensa Int, Eustis, FL USA.
RP Vasudevan, SK (corresponding author), EID Parry Ind Ltd, Parry Nutraceut, Chennai, Tamil Nadu, India.
EM subbukv@parry.murugappa.com
RI Cartwright, Elizabeth/AGN-2997-2022
CR Abu-Taweel GM, 2019, J INFECT PUBLIC HEAL, V12, P777, DOI 10.1016/j.jiph.2019.04.014
   Ama Moor Vicky Jocelyne, 2017, BMC Nutr, V3, P25, DOI 10.1186/s40795-017-0146-2
   [Anonymous], SPIRULINA MARKET TYP
   Belay A., 2002, JANA, V5, P27
   Bischoff SC, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-24
   Capelli B., 2010, Nutrafoods, V9, P19, DOI [10.1007/BF03223332, DOI 10.1007/BF03223332]
   Cerf Marlon E, 2013, Front Endocrinol (Lausanne), V4, P37, DOI 10.3389/fendo.2013.00037
   Chen YH, 2016, SCI REP-UK, V6, DOI 10.1038/srep24253
   Cingi C, 2008, EUR ARCH OTO-RHINO-L, V265, P1219, DOI 10.1007/s00405-008-0642-8
   de la Jara A, 2018, J APPL PHYCOL, V30, P2403, DOI 10.1007/s10811-018-1468-4
   Garcia FAD, 2020, KOR J GASTROENTEROL, V76, P150, DOI 10.4166/kjg.2020.76.3.150
   Desai K., 2004, ASIA PAC BIOTECH NEW, V8, P1298, DOI DOI 10.1142/S021903030400223X
   Ercolini D, 2018, J AGR FOOD CHEM, V66, P3754, DOI 10.1021/acs.jafc.8b00456
   Fei N, 2020, MBIO, V11, DOI 10.1128/mBio.03263-19
   Gutiérrez-Salmeán G, 2015, NUTR HOSP, V32, P34, DOI 10.3305/nh.2015.32.1.9001
   Hamedifard Z, 2019, PHYTOTHER RES, V33, P2609, DOI 10.1002/ptr.6441
   Hayashi K, 1996, AIDS RES HUM RETROV, V12, P1463, DOI 10.1089/aid.1996.12.1463
   Hayashi O., 1999, J Kagawa Nutr Univ, V30, P27
   Hernández-Corona A, 2002, ANTIVIR RES, V56, P279, DOI 10.1016/S0166-3542(02)00132-8
   Hu JL, 2019, FRONT CELL INFECT MI, V9, DOI 10.3389/fcimb.2019.00243
   Kalafati M, 2010, MED SCI SPORT EXER, V42, P142, DOI 10.1249/MSS.0b013e3181ac7a45
   Kardinaal, 2019, 6 INT C FOOD DIG GRA
   Karkos PD, 2011, EVID-BASED COMPL ALT, V2011, P1, DOI 10.1093/ecam/nen058
   Khan Z, 2005, CURR PHARM BIOTECHNO, V6, P373, DOI 10.2174/138920105774370607
   Kim HM, 1998, BIOCHEM PHARMACOL, V55, P1071, DOI 10.1016/S0006-2952(97)00678-3
   Kwon Hyokjoon, 2013, Front Endocrinol (Lausanne), V4, P71, DOI 10.3389/fendo.2013.00071
   Li TT, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19103075
   Lordan R, 2021, MSYSTEMS, V6, DOI 10.1128/mSystems.00122-21
   Mao TK, 2005, J MED FOOD, V8, P27, DOI 10.1089/jmf.2005.8.27
   Marcel AK, 2011, NUTRIENTS, V3, P712, DOI 10.3390/nu3070712
   Mathur M, 2018, Bioactive Molecules in Food, DOI DOI 10.1007/978-3-319-54528-897-1
   McCarty MF, 2020, PROG CARDIOVASC DIS, V63, P383, DOI 10.1016/j.pcad.2020.02.007
   Neyrinck AM, 2017, NUTRIENTS, V9, DOI 10.3390/nu9060633
   Ngo-Matip ME, 2015, NUTR J, V14, DOI 10.1186/s12937-015-0058-4
   Nuhu A.A., 2013, J MAR BIOL, DOI DOI 10.1155/2013/325636
   Okumura R, 2017, EXP MOL MED, V49, DOI 10.1038/emm.2017.20
   Parikh Panam, 2001, J Med Food, V4, P193, DOI 10.1089/10966200152744463
   Raj TK, 2020, INT J PHARM SCI RES, V11, P4271, DOI 10.13040/IJPSR.0975-8232.11(9).4271-78
   Ravi M, 2010, NUTR DIET SUPPL, V2, P73
   Romay C, 1998, INFLAMM RES, V47, P36, DOI 10.1007/s000110050256
   Selmi C, 2011, CELL MOL IMMUNOL, V8, P248, DOI 10.1038/cmi.2010.76
   Szulinska M, 2017, EUR REV MED PHARMACO, V21, P2473
   van den Brink W, 2019, FRONT NUTR, V6, DOI 10.3389/fnut.2019.00129
   Yang HN, 1997, LIFE SCI, V61, P1237, DOI 10.1016/S0024-3205(97)00668-1
   Yu T, 2020, J CELL MOL MED, V24, P8603, DOI 10.1111/jcmm.15489
NR 45
TC 2
Z9 2
U1 6
U2 22
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 2468-8827
EI 2468-8835
J9 INT J NONCOMMUN DIS
JI Int. J. Noncommun. Dis.
PD NOV
PY 2021
VL 6
IS 5
SU S
SI SI
BP 47
EP 54
DI 10.4103/2468-8827.330650
PG 8
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 4W6BT
UT WOS:000860246200007
OA gold
DA 2025-06-11
ER

PT J
AU Choi, JR
   Park, S
   Kim, SK
   Kim, JY
   Lee, K
   Oh, SS
   Koh, SB
AF Choi, Jung Ran
   Park, Sungjin
   Kim, Sung-Kyung
   Kim, Jae-Yeop
   Lee, Kyungsuk
   Oh, Sung-Soo
   Koh, Sang Baek
TI Mitochondrial DNA content and deletion ratio are associated with
   metabolic syndrome in a general population exposed to pesticide
SO MOLECULAR & CELLULAR TOXICOLOGY
LA English
DT Article
DE mtDNA copy number; Deletion ratio; Metabolic syndrome; Pesticide
   exposure
ID COPY NUMBER; OXIDATIVE STRESS; BIOMARKER; OBESITY; BLOOD
AB Background Mitochondrial DNA (mtDNA) copy number and deletion ratio may be asymmetrically determined using physiologic or pathologic conditions. Mitochondrial dysfunction is associated with an increased risk of developing metabolic syndrome (MetS). Objective Here, we investigated the association between mtDNA copy number and/or deletion ratio and the risk of developing MetS in a general population exposed to the pesticide. We examined 215 randomly sampled adults who were exposed to pesticide but did not present with MetS in a prospective cohort study. Both mtDNA copy number and deletion ratio were determined using quantitative real-time polymerase chain reaction. Results During the average 2.8-year follow-up period, 76 (35.3%) participants developed new-onset MetS. The numbers of mtDNA copies were significantly lower in participants with new-onset MetS than in those without MetS (112.15 +/- 26.15 vs. 133.13 +/- 44.44, p < 0.001), whereas the mtDNA deletion ratios were higher in participants with MetS than in those without MetS (10.59 +/- 11.96 vs. 4.52 +/- 6.74, p < 0.001). In the multivariate-adjusted models, the participants with a higher tertile of mtDNA copy number were 0.355 times more likely to develop MetS than those with the lowest tertile [odds ratio (OR) 0.355, 95% confidence interval (CI) 0.150-0.841, p = 0.004]. A higher mtDNA deletion ratio was significantly associated with the risk of developing MetS in populations exposed to pesticide (OR 5.062, 95% CI 1.164-22.004, p = 0.004). Conclusion A lower mtDNA copy number and higher deletion ratio were independent predictors for new-onset MetS in a general population exposed to the pesticide.
C1 [Choi, Jung Ran; Koh, Sang Baek] Yonsei Univ, Inst Genom Cohort, Wonju Coll Med, Wonju 26426, South Korea.
   [Park, Sungjin] Yonsei Univ, Grad Sch, Seoul, South Korea.
   [Park, Sungjin] Hongseong Med Ctr, Dept Occupat & Environm Med, Hongseong, South Korea.
   [Kim, Sung-Kyung; Kim, Jae-Yeop; Oh, Sung-Soo; Koh, Sang Baek] Yonsei Univ, Wonju Coll Med, Dept Occupat & Environm Med, Wonju, South Korea.
   [Kim, Sung-Kyung; Kim, Jae-Yeop; Oh, Sung-Soo; Koh, Sang Baek] Yonsei Univ, Wonju Coll Med, Dept Prevent Med, Wonju 26426, South Korea.
   [Kim, Sung-Kyung; Kim, Jae-Yeop; Oh, Sung-Soo; Koh, Sang Baek] Yonsei Univ, Wonju Coll Med, Inst Occupat & Environm Med, Wonju 26426, South Korea.
   [Lee, Kyungsuk] Rural Dev Adm, Natl Acad Agr Sci, Jeonju, South Korea.
   [Koh, Sang Baek] Yonsei Univ, Ctr Global Hlth & Social Med, Inst Poverty Alleviat & Int Dev, Wonju, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University; Yonsei
   University; Yonsei University; Rural Development Administration (RDA),
   Republic of Korea; Yonsei University
RP Choi, JR; Koh, SB (corresponding author), Yonsei Univ, Inst Genom Cohort, Wonju Coll Med, Wonju 26426, South Korea.; Koh, SB (corresponding author), Yonsei Univ, Wonju Coll Med, Dept Occupat & Environm Med, Wonju, South Korea.; Koh, SB (corresponding author), Yonsei Univ, Wonju Coll Med, Dept Prevent Med, Wonju 26426, South Korea.; Koh, SB (corresponding author), Yonsei Univ, Wonju Coll Med, Inst Occupat & Environm Med, Wonju 26426, South Korea.; Koh, SB (corresponding author), Yonsei Univ, Ctr Global Hlth & Social Med, Inst Poverty Alleviat & Int Dev, Wonju, South Korea.
EM christinae@yonsei.ac.kr; psjin9318@gmail.com; stacte@yonsei.ac.kr;
   kimjy87330@gmail.com; leeks81@korea.kr; oss0609@yonsei.ac.kr;
   kohhj@yonsei.ac.kr
RI PARK, SUNGJIN/AAJ-3406-2020; Kim, Yongkang/AAC-7436-2020; Kim,
   Sung-Kyung/GLU-8569-2022
OI Kim, Sung-Kyung/0000-0002-2742-6410
FU National Research Foundation of Korea (NRF) - Ministry of Education
   [2017R1D1A3B03034119]; Medical Research Center Program
   [2017R1A5A2015369]; Cooperative Research Program for Agriculture Science
   & Technology Development Rural Development Administration, Republic of
   Korea [PJ01250901]; Yonsei University
FX This research was supported by the Basic Science Research Program
   through the National Research Foundation of Korea (NRF), funded by the
   Ministry of Education (2017R1D1A3B03034119). Moreover, this research was
   supported by the Medical Research Center Program 2017R1A5A2015369. This
   work was carried out with the support of the Cooperative Research
   Program for Agriculture Science & Technology Development (project no.:
   PJ01250901) Rural Development Administration, Republic of Korea. This
   work was supported (in part) by the Yonsei University Research Fund of
   2017.
CR Alavanja MCR, 2013, CA-CANCER J CLIN, V63, P120, DOI 10.3322/caac.21170
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Ashar FN, 2017, JAMA CARDIOL, V2, P1247, DOI 10.1001/jamacardio.2017.3683
   Cho YM, 2007, DIABETES RES CLIN PR, V77, pS172, DOI 10.1016/j.diabres.2007.01.052
   Huang CH, 2011, J ATHEROSCLER THROMB, V18, P867, DOI 10.5551/jat.8698
   Jha SK, 2017, BBA-MOL BASIS DIS, V1863, P1132, DOI 10.1016/j.bbadis.2016.06.015
   Jung DH, 2016, COMPLEMENT THER MED, V24, P40, DOI 10.1016/j.ctim.2015.12.001
   Kahn BB, 2000, J CLIN INVEST, V106, P473, DOI 10.1172/JCI10842
   Kim JY, 2017, DIABETES METAB, V43, P280, DOI 10.1016/j.diabet.2016.09.007
   Kim JH, 2012, MENOPAUSE, V19, P582, DOI 10.1097/gme.0b013e31823a3e46
   Lee HC, 2000, BIOCHEM J, V348, P425, DOI 10.1042/0264-6021:3480425
   Lee HK, 2010, BBA-GEN SUBJECTS, V1800, P282, DOI 10.1016/j.bbagen.2009.11.010
   Lee JE, 2009, EXP MOL MED, V41, P253, DOI 10.3858/emm.2009.41.4.028
   Lee SY, 2007, DIABETES RES CLIN PR, V75, P72, DOI 10.1016/j.diabres.2006.04.013
   Liu CS, 2003, FREE RADICAL RES, V37, P1307, DOI 10.1080/10715760310001621342
   Lozano-Paniagua D, 2018, ECOTOX ENVIRON SAFE, V162, P121, DOI 10.1016/j.ecoenv.2018.06.074
   Malik AN, 2013, MITOCHONDRION, V13, P481, DOI 10.1016/j.mito.2012.10.011
   McCauley LA, 2006, ENVIRON HEALTH PERSP, V114, P953, DOI 10.1289/ehp.8526
   Meissner C, 2008, EXP GERONTOL, V43, P645, DOI 10.1016/j.exger.2008.03.004
   Mozhei O I, 2014, Mol Biol (Mosk), V48, P677
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Phillips NR, 2014, SCI REP-UK, V4, DOI 10.1038/srep03887
   Semren TZ, 2018, ARH HIG RADA TOKSIKO, V69, P109, DOI 10.2478/aiht-2018-69-3118
   Sperling LS, 2015, J AM COLL CARDIOL, V66, P1050, DOI 10.1016/j.jacc.2015.06.1328
   Vecoli C, 2018, ATHEROSCLEROSIS, V276, P91, DOI 10.1016/j.atherosclerosis.2018.07.015
NR 25
TC 3
Z9 3
U1 0
U2 4
PU KOREAN SOCIETY TOXICOGENOMICS & TOXICOPROTEOMICS-KSTT
PI GYEONGGI-DO
PA HANYANG UNIV, SCI & TECHNOL BLDG 1, RM 423, SA-DONG, SANGROK-GU, ANSAN,
   GYEONGGI-DO, 426 791, SOUTH KOREA
SN 1738-642X
EI 2092-8467
J9 MOL CELL TOXICOL
JI Mol. Cell. Toxicol.
PD JUL
PY 2020
VL 16
IS 3
BP 347
EP 354
DI 10.1007/s13273-020-00079-5
EA MAR 2020
PG 8
WC Biochemistry & Molecular Biology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Toxicology
GA MB7ZO
UT WOS:000522925300001
DA 2025-06-11
ER

PT J
AU Pérez, MJ
   Zampini, IC
   Alberto, MR
   Isla, MI
AF Perez, Maria J.
   Zampini, Iris C.
   Alberto, Maria R.
   Isla, Maria I.
TI Prosopis nigra Mesocarp Fine Flour, A Source of Phytochemicals
   with Potential Effect on Enzymes Linked to Metabolic Syndrome, Oxidative
   Stress, and Inflammatory Process
SO JOURNAL OF FOOD SCIENCE
LA English
DT Article
DE bound phenolics; free phenolics; mesocarp flour; metabolic syndrome;
   Prosopis nigra
ID ANTIOXIDANT PROPERTIES; GEOFFROEA-DECORTICANS; PHENOLIC-COMPOUNDS; ALBA
   PODS; FRACTIONS; L.; ANTHOCYANINS; INHIBITORS; PROFILES; CAPACITY
AB This work is part of the search in native food matrices from arid regions of Argentina of interest to improve human health. Prosopis species are ethnic food resources in South America capable of growing in arid and semi-arid environments. This work was focused to determine the nutritional and phytochemical composition of Prosopis nigra fine flour and to evaluate its biological properties. Flour showed a high level of sucrose (30.35 g/100 mu g flour), fiber (6.34 g/100 g flour), polyphenols (0.45 g GAE/100 g flour), and minerals (potassium, calcium, and magnesium). Apigenin C glycosides and phenylpropanoid acids were identified in free and bound phenolic enriched extracts, respectively. Polyphenols (especially free polyphenols) were able to inhibit enzymes associated with the metabolic syndrome, including alpha-amylase (IC50 30.1 mu g GAE/mL), alpha-glucosidase (IC50 22.5 mu g GAE/mL), while bound phenolics may control lipase activity (IC50 33.5 mu g GAE/mL) and exhibit antioxidant activity by different action mechanisms (SC50 between 16 and 93 mu g GAE/mL). Both extracts were more effective to inhibit cyclooxygenase-2 than phospholipase A(2) and lipoxygenase, proinflammatory enzymes. Polyphenolic extracts did not show any mutagenic effect. Our studies add value to this non-conventional flour as a promising food resource that could be used as a functional food or functional ingredient in formulations to reduce the risk of the development of obesity. These studies revalue our native resources by promoting their conservation, their use and their propagation.
C1 [Perez, Maria J.; Zampini, Iris C.; Alberto, Maria R.; Isla, Maria I.] Univ Nacl Tucuman, Fac Ciencias Nat & IML, Inst Bioprospecc & Fisiol Vegetal INBIOFIV CONICE, San Miguel De Tucuman, Argentina.
C3 Universidad Nacional de Tucuman
RP Isla, MI (corresponding author), Univ Nacl Tucuman, Fac Ciencias Nat & IML, Inst Bioprospecc & Fisiol Vegetal INBIOFIV CONICE, San Miguel De Tucuman, Argentina.
EM misla@tucbbs.com.ar
RI Alberto, Maria Rosa/AAS-3062-2021
OI Isla, Maria Ines/0000-0002-4261-4284; Alberto, Maria
   Rosa/0000-0002-4173-9499
FU ANPCyT [PICT 3136]; SCAIT-UNT [PIUNT G-533]; CONICET (PIP)
FX We thank ANPCyT (PICT 3136) "Revalorizacion de frutos nativos del NOA y
   sus productos derivados como alimentos funcionales no convencionales,"
   CONICET (PIP) and SCAIT-UNT (PIUNT G-533) for financial support.
CR Abdel-Aal ESM, 2006, J AGR FOOD CHEM, V54, P4696, DOI 10.1021/jf0606609
   Abdul-Ghani MA, 2006, DIABETES CARE, V29, P1130, DOI 10.2337/dc05-2179
   [Anonymous], DAIRY SCI TECHNOLOGY
   AOAC, 1989, OFFICIAL METHODS ANA
   Bhaswant M, 2017, NUTRITION, V41, P24, DOI 10.1016/j.nut.2016.12.009
   Birari RB, 2007, DRUG DISCOV TODAY, V12, P879, DOI 10.1016/j.drudis.2007.07.024
   BURKART A, 1976, J ARNOLD ARBORETUM, V57, P219
   Cattaneo F, 2016, FOOD CHEM, V208, P89, DOI 10.1016/j.foodchem.2016.03.115
   Cos P, 1998, J NAT PROD, V61, P71, DOI 10.1021/np970237h
   Costamagna MS, 2016, FOOD CHEM, V190, P392, DOI 10.1016/j.foodchem.2015.05.068
   Costamagna MS, 2013, FOOD RES INT, V54, P160, DOI 10.1016/j.foodres.2013.05.038
   D'Almeida RE, 2013, J ETHNOPHARMACOL, V150, P1080, DOI 10.1016/j.jep.2013.10.014
   Orqueda ME, 2017, J FUNCT FOODS, V37, P531, DOI 10.1016/j.jff.2017.08.020
   Fernando CD, 2015, METHODSX, V2, P283, DOI 10.1016/j.mex.2015.05.001
   Gondoin A, 2010, FOOD RES INT, V43, P1537, DOI 10.1016/j.foodres.2010.04.029
   He B, 2016, FOOD CHEM, V204, P70, DOI 10.1016/j.foodchem.2016.02.094
   HOLM J, 1986, STARCH-STARKE, V38, P224, DOI 10.1002/star.19860380704
   Pérez MJ, 2014, FOOD RES INT, V64, P762, DOI 10.1016/j.foodres.2014.08.013
   Kumaran A, 2006, PLANT FOOD HUM NUTR, V61, P1, DOI 10.1007/s11130-006-0001-0
   Lao F, 2017, FOOD CHEM, V227, P376, DOI 10.1016/j.foodchem.2017.01.091
   Levine M, 2001, P NATL ACAD SCI USA, V98, P9842, DOI 10.1073/pnas.171318198
   Cardozo ML, 2010, FOOD RES INT, V43, P1505, DOI 10.1016/j.foodres.2010.04.004
   Lv JL, 2012, FOOD CHEM, V135, P325, DOI 10.1016/j.foodchem.2012.04.141
   MARON DM, 1983, MUTAT RES, V113, P173, DOI 10.1016/0165-1161(83)90010-9
   Min B, 2012, FOOD CHEM, V133, P715, DOI 10.1016/j.foodchem.2012.01.079
   Moore J, 2005, J AGR FOOD CHEM, V53, P6649, DOI 10.1021/jf050481b
   Önal A, 2005, J AOAC INT, V88, P490
   Ordoñez AAL, 2006, FOOD CHEM, V97, P452, DOI 10.1016/j.foodchem.2005.05.024
   Quispe C, 2014, FOOD RES INT, V56, P174, DOI 10.1016/j.foodres.2013.12.033
   Re R, 1999, FREE RADICAL BIO MED, V26, P1231, DOI 10.1016/S0891-5849(98)00315-3
   Ruzainah Ali Jaafar Ruzainah Ali Jaafar, 2009, American Journal of Applied Sciences, V6, P1341
   Sciammaro L, 2016, J FOOD MEAS CHARACT, V10, P103, DOI 10.1007/s11694-015-9282-z
   Swieca M, 2017, FOOD CHEM, V228, P643, DOI 10.1016/j.foodchem.2017.02.052
   Ti HH, 2014, FOOD CHEM, V159, P166, DOI 10.1016/j.foodchem.2014.03.029
   Valentao P, 2002, J AGR FOOD CHEM, V50, P4989, DOI 10.1021/jf020225o
   Van Hung P, 2009, FOOD RES INT, V42, P185, DOI 10.1016/j.foodres.2008.10.005
   Xiao JB, 2016, CRIT REV FOOD SCI, V56, pS29, DOI 10.1080/10408398.2015.1067595
NR 37
TC 21
Z9 21
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-1147
EI 1750-3841
J9 J FOOD SCI
JI J. Food Sci.
PD MAY
PY 2018
VL 83
IS 5
BP 1454
EP 1462
DI 10.1111/1750-3841.14113
PG 9
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA GF5MR
UT WOS:000432012200035
PM 29660809
OA Green Published
DA 2025-06-11
ER

PT J
AU Nogales, F
   Ojeda, ML
   del Valle, PM
   Serrano, A
   Murillo, ML
   Sánchez, OC
AF Nogales, Fatima
   Luisa Ojeda, M.
   Munoz del Valle, Paulina
   Serrano, Alejandra
   Luisa Murillo, M.
   Carreras Sanchez, Olimpia
TI Metabolic syndrome and selenium during gestation and lactation
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Metabolic syndrome; Selenium; Gestation; Lactation
ID OXIDATIVE STRESS; GLUTATHIONE-PEROXIDASE; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; FRUCTOSE; SUPPLEMENTATION; MICE; DEFICIENCY;
   CARBOHYDRATE; PREGNANCY
AB Selenium (Se) has a dual role in metabolic syndrome (MS) development as it has an antioxidant action against both "good" and "bad" reactive oxygen species. This study evaluates Se body profile in dams which present MS during gestation and lactation, in order to elucidate a normal dietary Se's implication in this pathology.
   Rats were randomized into control (C) and fructose (F) groups. The rich fructose diet (65 %) during gestation and lactation periods induced MS in dams. Se body distribution was determined by atomic absorption spectrophotometry, and the hepatic activity of the four antioxidant enzymes and the bimolecular oxidation were determined by spectrophotometry. The cardiac activity was monitored using the indirect tail occlusion method. Lipid and glucidic profile was also analyzed.
   Despite the fact that the diet supplied has 0.1 ppm of Se, the minimal dietary requirement for rats, F dams ate less amount of food, and therefore, they had lower Se retention. However, they had normal levels of Se in serum and milk. Dams with MS had Se depletion in heart and muscle joint to hypertension and a lower heart rate, and Se repletion in liver and kidney. Despite the increase in hepatic glutathione peroxidase (GPx) and catalase activity found, lipid oxidation occurred-probably because superoxide dismutase activity was diminished. In heart, the activity and expression of the selenoprotein GPx1 were decreased.
   With these results, it is not possible to elucidate whether a dietary Se supplementation or a Se-restricted diet are good for MS; because despite the fact that GPx activity is increased in liver, it is also found, for the first time, that heart Se deposits are significantly decreased during MS.
C1 [Nogales, Fatima; Luisa Ojeda, M.; Munoz del Valle, Paulina; Serrano, Alejandra; Luisa Murillo, M.; Carreras Sanchez, Olimpia] Univ Seville, Dept Physiol, Fac Pharm, C Prof Garcia Gonzalez 2, E-41012 Seville, Spain.
C3 University of Sevilla
RP Sánchez, OC (corresponding author), Univ Seville, Dept Physiol, Fac Pharm, C Prof Garcia Gonzalez 2, E-41012 Seville, Spain.
EM olimpia@us.es
RI Nogales, F/B-8562-2019; Carreras, olimpia/P-9078-2019; Ojeda,
   Luisa/B-8571-2019
OI Maria Luisa, Ojeda Murillo/0000-0002-9160-2749; Carreras,
   Olimpia/0000-0002-3858-0165; Nogales, Fatima/0000-0003-4844-2740
FU Andalusian Regional Government
FX The authors acknowledge the grants from Andalusian Regional Government
   for its support to CTS-193 research group.
CR Abdulla MH, 2011, INT J NEPHROL, V2011, DOI 10.4061/2011/934659
   Abdulla MH, 2012, J PHYSIOL BIOCHEM, V68, P353, DOI 10.1007/s13105-012-0147-1
   Abdulla MH, 2013, PAK J PHARM SCI, V26, P727
   Akram M, 2013, OBES RES CLIN PRACT, V7, pE89, DOI 10.1016/j.orcp.2012.11.002
   Armutcu F, 2008, CLIN CHEM LAB MED, V46, P785, DOI 10.1515/CCLM.2008.166
   Arnaud J, 2012, NUTR METAB CARDIOVAS, V22, P517, DOI 10.1016/j.numecd.2010.09.005
   BEERS RF, 1952, J BIOL CHEM, V195, P133
   Benstoem C, 2015, NUTRIENTS, V7, P3094, DOI 10.3390/nu7053094
   Brigelius-Flohé R, 2013, BBA-GEN SUBJECTS, V1830, P3289, DOI 10.1016/j.bbagen.2012.11.020
   Chen JS, 2012, ASIA PAC J CLIN NUTR, V21, P320
   Cheng SM, 2014, CELL BIOCHEM FUNCT, V32, P133, DOI 10.1002/cbf.2982
   COX NJ, 1994, DIABETES, V43, P166, DOI 10.2337/diab.43.1.166
   Daniels LA, 1996, BIOL TRACE ELEM RES, V54, P185, DOI 10.1007/BF02784430
   Day Caroline, 2007, Diab Vasc Dis Res, V4, P32, DOI 10.3132/dvdr.2007.003
   Delbosc S, 2005, ATHEROSCLEROSIS, V179, P43, DOI 10.1016/j.atherosclerosis.2004.10.018
   DRAPER HH, 1990, METHOD ENZYMOL, V186, P421
   Duntas LH, 2015, ENDOCRINE, V48, P756, DOI 10.1007/s12020-014-0477-6
   Elnakish MT, 2013, J PATHOL, V231, P290, DOI 10.1002/path.4255
   Fortuño A, 2006, DIABETES, V55, P209, DOI 10.2337/diabetes.55.1.209
   Fridovich I., 1985, HDB METHODS OXYGEN R, P213
   Gomez-Amores L, 2007, J NUTR BIOCHEM, V18, P533, DOI 10.1016/j.jnutbio.2006.10.004
   Harreiter J, 2014, WOMENS HEALTH, V10, P91, DOI [10.2217/whe.13.69, 10.2217/WHE.13.69]
   Jotty K, 2009, FOOD CHEM TOXICOL, V47, P2484, DOI 10.1016/j.fct.2009.07.006
   Jotty K, 2013, ALCOHOL, V47, P545, DOI 10.1016/j.alcohol.2013.07.004
   Kotronen A, 2007, J CLIN ENDOCR METAB, V92, P3490, DOI 10.1210/jc.2007-0482
   LAWRENCE RA, 1976, BIOCHEM BIOPH RES CO, V71, P952, DOI 10.1016/0006-291X(76)90747-6
   Li M, 2015, J NUTR BIOCHEM, V26, P267, DOI 10.1016/j.jnutbio.2014.10.015
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   Yubero-Serrano EM, 2013, EXP MOL MED, V45, DOI 10.1038/emm.2013.53
   McClung JP, 2004, P NATL ACAD SCI USA, V101, P8852, DOI 10.1073/pnas.0308096101
   Metes-Kosik N, 2012, MOL NUTR FOOD RES, V56, P1812, DOI 10.1002/mnfr.201200386
   Mueller AS, 2009, J NUTR BIOCHEM, V20, P235, DOI 10.1016/j.jnutbio.2008.02.007
   Feoli AMP, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/587083
   Pepper MP, 2011, ANTIOXID REDOX SIGN, V14, P383, DOI 10.1089/ars.2010.3295
   RAWANA S, 1993, J NUTR, V123, P2158
   Rayman MP, 2013, FREE RADICAL BIO MED, V65, P1557, DOI 10.1016/j.freeradbiomed.2013.04.003
   Reddi AS, 2001, KIDNEY INT, V59, P1342, DOI 10.1046/j.1523-1755.2001.0590041342.x
   Regnault TRH, 2013, CLIN EXP PHARMACOL P, V40, P824, DOI 10.1111/1440-1681.12162
   REZNICK AZ, 1994, METHOD ENZYMOL, V233, P357
   Seale LA, 2012, MOL CELL BIOL, V32, P4141, DOI 10.1128/MCB.00293-12
   Seboussi R, 2009, BIOL TRACE ELEM RES, V128, P45, DOI 10.1007/s12011-008-8251-3
   Sloboda DM, 2014, J OBES, V2014, DOI 10.1155/2014/203474
   Sreeja S., 2014, ISRN INFLAMM, V2014, P641096, DOI DOI 10.1155/2014/641096
   Stapleton SR, 2000, CELL MOL LIFE SCI, V57, P1874, DOI 10.1007/PL00000669
   Steinbrenner H, 2013, FREE RADICAL BIO MED, V65, P1538, DOI 10.1016/j.freeradbiomed.2013.07.016
   Stump CS, 2006, ANN MED, V38, P389, DOI 10.1080/07853890600888413
   SUBRAMANIAN MG, 1995, ALCOHOL, V12, P137, DOI 10.1016/0741-8329(94)00073-5
   Vickers MH, 2011, ENDOCRINOLOGY, V152, P1378, DOI 10.1210/en.2010-1093
   Wang X, 2014, TOXICOL LETT, V224, P16, DOI 10.1016/j.toxlet.2013.10.005
   WORTHINGTON DJ, 1974, EUR J BIOCHEM, V48, P167, DOI 10.1111/j.1432-1033.1974.tb03754.x
   Xu Tian-jiao, 2011, Yaoxue Xuebao, V46, P274
   Yoshida T, 1997, CIRCULATION, V96, P216
   Yoshida T, 1996, J MOL CELL CARDIOL, V28, P1759, DOI 10.1006/jmcc.1996.0165
   Zhou J, 2013, FREE RADICAL BIO MED, V65, P1548, DOI 10.1016/j.freeradbiomed.2013.07.012
   Zou M, 2012, NUTR RES, V32, P588, DOI 10.1016/j.nutres.2012.06.012
NR 55
TC 15
Z9 15
U1 0
U2 8
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD MAR
PY 2017
VL 56
IS 2
BP 819
EP 830
DI 10.1007/s00394-015-1129-1
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EN5IR
UT WOS:000396039300034
PM 26680597
DA 2025-06-11
ER

PT J
AU Tabur, S
   Oztuzcu, S
   Oguz, E
   Korkmaz, H
   Eroglu, S
   Ozkaya, M
   Demiryürek, AT
AF Tabur, S.
   Oztuzcu, S.
   Oguz, E.
   Korkmaz, H.
   Eroglu, S.
   Ozkaya, M.
   Demiryurek, A. T.
TI Association of Rho/Rho-kinase gene polymorphisms and expressions with
   obesity-related metabolic syndrome
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Diabetes mellitus; Metabolic syndrome; Obesity; Rhokinase; Rho proteins
ID SMOOTH-MUSCLE-CELLS; RHO-KINASE; INSULIN-RESISTANCE; ENDOTHELIAL-CELLS;
   OXIDATIVE STRESS; PROTEINS; CHOLESTEROL; POPULATION; VARIANTS; PATHWAY
AB OBJECTIVE: The metabolic syndrome (MetS) is a common multicomponent condition including abdominal obesity, dyslipidemia, hypertension and hyperglycemia. The aim of this study was to investigate the associations of Rho GTPase and Rho-kinase (ROCK) gene polymorphisms and expressions with MetS in a Turkish population.
   PATIENTS AND METHODS: A total of 141 obese MetS patients and 163 healthy controls with similar age and sex were included to this study. Polymorphisms were analyzed in genomic DNA using a BioMark 96.96 dynamic array system. mRNA from blood samples was extracted, and real-time polymerase chain reaction was performed for gene expressions.
   RESULTS: We observed that genotype (CC, 18.1%; CA, 13.4%, and AA, 68.5%) and allele (C, 24.8%; A, 75.2%) frequencies for the rs35996865 polymorphism of the ROCK1 gene in patients were markedly different from controls (CC, 84.2%; CA, 2.9%, and AA, 12.9%; C, 85.6%; A, 14.4%, p < 0.0001). In the rs2230774 (Thr431Asn) polymorphism of the ROCK2 gene, there were increases in the CC genotype (16.5%) and C allele frequencies (20.4%) in MetS patients when compared with the control group (CC, 6.0%, p = 0.0009, and C, 6.7%, p < 0.0001). However, no associations with the other 18 polymorphisms studied were found. Although there were an increase in peripheral blood mRNA RhoH expressions, marked decreases in RhoC, RhoBTB1, RhoV, Rnd1, and CDC42 gene expressions were noted in MetS patients.
   CONCLUSIONS: This is the first study to provide evidence that ROCK gene polymorphisms and gene expressions of the Rho GTPase proteins may modify individual susceptibility to MetS in the Turkish population.
C1 [Tabur, S.; Korkmaz, H.; Ozkaya, M.] Gaziantep Univ, Fac Med, Dept Internal Med, Div Endocrinol, Gaziantep, Turkey.
   [Oztuzcu, S.; Eroglu, S.] Gaziantep Univ, Fac Med, Dept Med Biol, Gaziantep, Turkey.
   [Oguz, E.] Harran Univ, Fac Med, Dept Med Pharmacol, Sanliurfa, Turkey.
   [Demiryurek, A. T.] Gaziantep Univ, Fac Med, Dept Med Pharmacol, Gaziantep, Turkey.
C3 Gaziantep University; Gaziantep University; Harran University; Gaziantep
   University
RP Tabur, S (corresponding author), Gaziantep Univ, Fac Med, Dept Internal Med, Div Endocrinol, Gaziantep, Turkey.
EM suzan2471@yahoo.com.tr
RI Eroglu, Secil/P-2209-2019; Demiryurek, Abdullah/AAG-5244-2020; Oguz,
   Elif/KCZ-1767-2024
OI Eroglu, Secil/0000-0002-1536-1736
CR Aspenström P, 2004, BIOCHEM J, V377, P327, DOI 10.1042/BJ20031041
   Begum N, 2002, J BIOL CHEM, V277, P6214, DOI 10.1074/jbc.M110508200
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Daryadel A, 2009, J IMMUNOL, V182, P6527, DOI 10.4049/jimmunol.0803846
   Demiryurek AT, 2010, CURR EYE RES, V35, P1128, DOI 10.3109/02713683.2010.507903
   Fall T, 2014, MOL CELL ENDOCRINOL, V382, P740, DOI 10.1016/j.mce.2012.08.018
   Ferrannini E, 2002, DIABETIC MED, V19, P724, DOI 10.1046/j.1464-5491.2002.00794.x
   Ferrannini E, 2006, ANN MED, V38, P42, DOI 10.1080/07853890500415358
   Fujita K, 2006, CIRC J, V70, P1437, DOI 10.1253/circj.70.1437
   Furukawa N, 2005, CELL METAB, V2, P119, DOI 10.1016/j.cmet.2005.06.011
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Gündogdu MS, 2010, MOL CANCER, V9, DOI 10.1186/1476-4598-9-225
   Guo XQ, 2005, HYPERTENSION, V45, P799, DOI 10.1161/01.HYP.0000154786.17416.ea
   Hiroki J, 2004, J MOL CELL CARDIOL, V37, P537, DOI 10.1016/j.yjmcc.2004.05.008
   Jin LM, 2004, AM J PHYSIOL-HEART C, V287, pH1495, DOI 10.1152/ajpheart.01006.2003
   Kanda T, 2005, FASEB J, V19, P169, DOI 10.1096/fj.05-4197fje
   Li XY, 2002, MOL CELL BIOL, V22, P1158, DOI 10.1128/MCB.22.4.1158-1171.2002
   Liu PY, 2007, J AM COLL CARDIOL, V49, P1619, DOI 10.1016/j.jacc.2006.12.043
   Loirand G, 2013, PHYSIOL REV, V93, P1659, DOI 10.1152/physrev.00021.2012
   Milagro FI, 2006, OBESITY, V14, P1118, DOI 10.1038/oby.2006.128
   Naik JS, 2006, AM J PHYSIOL-REG I, V290, pR154, DOI 10.1152/ajpregu.00245.2005
   Nofer JR, 2003, J BIOL CHEM, V278, P53055, DOI 10.1074/jbc.M305673200
   Prieto D, 2014, CURR VASC PHARMACOL, V12, P412, DOI 10.2174/1570161112666140423221008
   Rikitake Y, 2005, CIRCULATION, V111, P3261, DOI 10.1161/CIRCULATIONAHA.105.534024
   Sadok Amine, 2014, Small GTPases, V5, pe29710, DOI 10.4161/sgtp.29710
   Schinzari F, 2012, AM J PHYSIOL-ENDOC M, V303, pE806, DOI 10.1152/ajpendo.00206.2012
   Seasholtz TM, 2006, HYPERTENSION, V47, P937, DOI 10.1161/01.HYP.0000217364.45622.f0
   Sordella R, 2003, CELL, V113, P147, DOI 10.1016/S0092-8674(03)00271-X
   Tabur S, 2015, EUR REV MED IN PRESS
   Usui I, 2003, J BIOL CHEM, V278, P13765, DOI 10.1074/jbc.M208904200
   Vincent HK, 2006, INT J OBESITY, V30, P400, DOI 10.1038/sj.ijo.0803177
   Warton K, 2004, GENE, V342, P85, DOI 10.1016/j.gene.2004.07.027
   Wennerberg K, 2003, CURR BIOL, V13, P1106, DOI 10.1016/S0960-9822(03)00418-4
   Wheeler AP, 2004, EXP CELL RES, V301, P43, DOI 10.1016/j.yexcr.2004.08.012
   Yazici HU, 2012, EUR REV MED PHARMACO, V16, P90
   Yoshida T, 2009, INT J MOL MED, V24, P233, DOI 10.3892/ijmm_00000226
   Zhao Q, 2008, PHARMACOGENET GENOM, V18, P459, DOI 10.1097/FPC.0b013e3282f97fb2
   Zhou QA, 2011, TRENDS PHARMACOL SCI, V32, P167, DOI 10.1016/j.tips.2010.12.006
NR 39
TC 17
Z9 19
U1 0
U2 4
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PD MAY
PY 2015
VL 19
IS 9
BP 1680
EP 1688
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CJ8IV
UT WOS:000355744400021
PM 26004609
DA 2025-06-11
ER

PT J
AU Liu, J
   Shi, WQ
   Cao, Y
   He, LP
   Guan, K
   Ling, WH
   Chen, YM
AF Liu, Jun
   Shi, Wen-qi
   Cao, Yi
   He, Li-ping
   Guan, Ke
   Ling, Wen-hua
   Chen, Yu-ming
TI Higher serum carotenoid concentrations associated with a lower
   prevalence of the metabolic syndrome in middle-aged and elderly Chinese
   adults
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Carotenoids; Serum; Metabolic syndrome; Cross-sectional studies
ID ANTIOXIDANT CONCENTRATIONS; ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS;
   RISK; MARKERS; HEALTH
AB The association between serum carotenoids and the metabolic syndrome (MetS) remains uncertain, and little is known about this relationship in the Chinese population. The present study examined the association between serum carotenoid concentrations and the MetS in Chinese adults. We conducted a community-based cross-sectional study in which 2148 subjects (1547 women and 601 men) aged 50-75 years were recruited in urban Guangzhou, China. Dietary data and other covariates were collected during face-to-face interviews. Blood pressure, waist circumference, blood lipids, glucose and serum carotenoids (alpha-, beta-carotene, beta-cryptoxanthin, lycopene and lutein/zeaxanthin) were examined. We found dose-response inverse relationships between individual serum carotenoid concentrations and total carotenoids and the prevalence of the MetS after adjusting for potential confounders (P for trend <0.001). The OR of the MetS for the highest (v. lowest) quartile were 0.31 (95% CI 0.20, 0.47) for alpha-carotene, 0.23 (95% CI 0.15, 0.36) for beta-carotene, 0.44 (95% CI 0.29, 0.67) for beta-cryptoxanthin, 0.39 (95% CI 0.26, 0.58) for lycopene, 0.28 (95% CI 0.18, 0.44) for lutein + zeaxanthin and 0.19 (95% CI 0.12, 0.30) for total carotenoids. Higher concentrations of each individual carotenoid and total carotenoids were significantly associated with a decrease in the number of abnormal MetS components (P for trend <0.001-0.023). Higher serum carotenoid levels were associated with a lower prevalence of the MetS and fewer abnormal MetS components in middle-aged and elderly Chinese adults.
C1 [Liu, Jun; Shi, Wen-qi; Cao, Yi; He, Li-ping; Guan, Ke; Ling, Wen-hua; Chen, Yu-ming] Sun Yat Sen Univ, Dept Med Stat & Epidemiol, Sch Publ Hlth, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Guangdong, Peoples R China.
   [Liu, Jun] Zunyi Med Univ, Sch Publ Hlth, Zunyi 563003, Guizhou, Peoples R China.
   [He, Li-ping] Guangzhou Panyu Cent Hosp, Guangzhou 511430, Guangdong, Peoples R China.
C3 Sun Yat Sen University; Zunyi Medical University
RP Chen, YM (corresponding author), Sun Yat Sen Univ, Dept Med Stat & Epidemiol, Sch Publ Hlth, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Guangdong, Peoples R China.
EM chenyum@mail.sysu.edu.cn
OI chen, Yu-ming/0000-0003-1658-5528
FU National Natural Science Foundation of China [81130052]; Sun Yat-sen
   University, Guangzhou, People's Republic of China [2007032]
FX The present study was jointly supported by the Key Program of National
   Natural Science Foundation of China (no. 81130052) and the 5010 Program
   for Clinical Researches (no. 2007032) by the Sun Yat-sen University,
   Guangzhou, People's Republic of China. The sponsor had no role in the
   design and analysis of the study or in the writing of this article.
CR Ainsworth BE, 2011, MED SCI SPORT EXER, V43, P1575, DOI 10.1249/MSS.0b013e31821ece12
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Amiri F, 2009, J HYPERTENS, V27, P1352, DOI 10.1097/HJH.0b013e32832d1f9e
   Andersen LF, 2006, BRIT J NUTR, V95, P358, DOI 10.1079/BJN20051638
   Andreassi MG, 2009, MUTAT RES-FUND MOL M, V667, P35, DOI 10.1016/j.mrfmmm.2008.10.018
   Beydoun MA, 2012, J NUTR, V142, P1693, DOI 10.3945/jn.112.160416
   Beydoun MA, 2011, J NUTR, V141, P903, DOI 10.3945/jn.110.136580
   Burri BJ, 2003, J CHROMATOGR A, V987, P359, DOI 10.1016/S0021-9673(02)01908-8
   Ciccone MM, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/782137
   Coyne T, 2009, BRIT J NUTR, V102, P1668, DOI 10.1017/S000711450999081X
   Czernichow S, 2009, AM J CLIN NUTR, V90, P329, DOI 10.3945/ajcn.2009.27635
   Fiedor J, 2014, NUTRIENTS, V6, P466, DOI 10.3390/nu6020466
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Giordano P, 2012, CURR PHARM DESIGN, V18, P5577, DOI 10.2174/138161212803307527
   Gouranton E, 2011, J NUTR BIOCHEM, V22, P642, DOI 10.1016/j.jnutbio.2010.04.016
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Gu DF, 2005, LANCET, V365, P1398, DOI 10.1016/S0140-6736(05)66375-1
   He Y, 2006, J AM COLL CARDIOL, V47, P1588, DOI 10.1016/j.jacc.2005.11.074
   Hopps E, 2010, NUTR METAB CARDIOVAS, V20, P72, DOI 10.1016/j.numecd.2009.06.002
   Hozawa A, 2007, CLIN CHEM, V53, P447, DOI 10.1373/clinchem.2006.074930
   Kereiakes DJ, 2003, CIRCULATION, V108, P1552, DOI 10.1161/01.CIR.0000093203.00632.2B
   Krinsky Norman I., 2005, Molecular Aspects of Medicine, V26, P459
   Marcotorchino J, 2012, MOL NUTR FOOD RES, V56, P725, DOI 10.1002/mnfr.201100623
   Otani H, 2011, ANTIOXID REDOX SIGN, V15, P1911, DOI 10.1089/ars.2010.3739
   Phillips C, 2006, CURR OPIN CARDIOL, V21, P185, DOI 10.1097/01.hco.0000221579.25878.11
   Povel CM, 2011, OBES REV, V12, P952, DOI 10.1111/j.1467-789X.2011.00907.x
   Rakugi H, 2005, CURR HYPERTENS REP, V7, P103, DOI 10.1007/s11906-005-0082-4
   Reaven G, 2002, CIRCULATION, V106, P286, DOI 10.1161/01.CIR.0000019884.36724.D9
   Sugiura M, 2008, BRIT J NUTR, V100, P1297, DOI 10.1017/S0007114508978302
   Suzuki K, 2011, CLIN NUTR, V30, P369, DOI 10.1016/j.clnu.2010.12.006
   Suzuki T, 2008, AM HEART J, V156, P405, DOI 10.1016/j.ahj.2008.02.022
   Xu XR, 2012, CLIN BIOCHEM, V45, P1357, DOI 10.1016/j.clinbiochem.2012.07.101
   Yang YX., 2004, China food composition
   Young AJ, 2001, ARCH BIOCHEM BIOPHYS, V385, P20, DOI 10.1006/abbi.2000.2149
   Zhang CX, 2009, ASIA PAC J CLIN NUTR, V18, P240
NR 35
TC 49
Z9 52
U1 0
U2 17
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD DEC 28
PY 2014
VL 112
IS 12
BP 2041
EP 2048
DI 10.1017/S000711451400316X
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AX7OA
UT WOS:000347103800016
PM 25345663
OA Bronze
DA 2025-06-11
ER

PT J
AU Shab-Bidar, S
   Hosseini-Esfahani, F
   Mirmiran, P
   Mehran, M
   Azizi, F
AF Shab-Bidar, Sakineh
   Hosseini-Esfahani, Firoozeh
   Mirmiran, Parvin
   Mehran, Mahya
   Azizi, Fereidoun
TI Dietary intakes of zinc and copper and cardiovascular risk factors in
   Tehranian adults: Tehran Lipid and Glucose Study
SO NUTRITION & DIETETICS
LA English
DT Article
DE cardiovascular disease risk factor; copper; dietary intake; metabolic
   syndrome; zinc
ID CORONARY-ARTERY-DISEASE; OXIDATIVE STRESS; SERUM COPPER; METABOLIC
   SYNDROME; HEART-DISEASE; SUPPLEMENTATION; PREVENTION; MAGNESIUM; PLASMA;
   CANCER
AB AimThe aim of the present study was to investigate the intakes of zinc and copper in relation to cardiovascular disease (CVD) risk factors in a group of Tehranian adults.
   MethodsThe present cross-sectional study was conducted on 2750 individuals, selected among participants of the Tehran Lipid and Glucose Study. Dietary intake was assessed using a validated semi-quantitative food frequency questionnaire. Metabolic syndrome (MetS) and CVD risk factors were evaluated.
   ResultsAfter adjustment of possible confounders, the dietary zinc intake was found to have a negative relation with serum HDL-C ( = -0.47, P = 0.027), triglycerides (TG) ( = -0.003, P = 0.032) and 2-hour blood glucose ( = -1.6, P = 0.017) levels in women. Prevalence of MetS was not associated with dietary zinc intake when confounding factors were included in the statistical model. Comparing the highest versus the lowest intake categories of dietary copper, the multivariable adjusted odds ratios for HDL-C, fasting blood glucose(FBG), TG and MetS were 1.75 (1.43-2.25)(P for trend = 0.003), 0.90 (0.76-1.23)(P for trend = 0.017), 0.11(0.08-0.21) (P for trend = 0.042) and 0.19 (0.15-0.38)(P for trend = 0.023), respectively.
   ConclusionsThe results indicate gender differences in the association between zinc intake and CVD risk factors; in women, lower consumption of dietary zinc was associated with increased levels of serum TG and 2-hour BG and decreased levels of HDL-C, while Copper intake was negatively associated with higher risk of MetS and its components (FBG, HDL-C and TG).
C1 [Shab-Bidar, Sakineh; Hosseini-Esfahani, Firoozeh; Mehran, Mahya] Shahid Beheshti Univ Med Sci, Nutr & Endocrine Res Ctr, Obes Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
   [Mirmiran, Parvin] Shahid Beheshti Univ Med Sci, Dept Human Nutr & Dietet, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, Tehran, Iran.
   [Azizi, Fereidoun] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Res Ctr, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Shahid Beheshti University Medical Sciences
RP Mirmiran, P (corresponding author), Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Obes Res Ctr, POB 19395-4763, Tehran, Iran.
EM parvin.mirmiran@gmail.com
RI Mirmiran, Parvin/V-1433-2019; Shab-Bidar, Sakineh/H-9525-2017;
   Hosseini-Esfahani, Firoozeh/K-9532-2017; Azizi, Fereidoun/ABD-4136-2021
OI Shab-Bidar, Sakineh/0000-0002-0167-7174; Hosseini-Esfahani,
   Firoozeh/0000-0002-9697-0081; Mirmiran, Parvin/0000-0003-2391-4924;
   Azizi, Fereidoun/0000-0002-6470-2517
FU National Research Council of the Islamic Republic of Iran [121];
   Research Institute for Endocrinology and Metabolism, Shahid Beheshti
   University of Medical Sciences [121]
FX The present study was supported by grant no. 121 from the combined
   support of the National Research Council of the Islamic Republic of Iran
   and Research Institute for Endocrinology and Metabolism, Shahid Beheshti
   University of Medical Sciences. No financial conflict of interest was
   reported by the authors of the present paper.
CR Afkhami-Ardekani M., 2008, Pakistan Journal of Nutrition, V7, P550, DOI 10.3923/pjn.2008.550.553
   Ainsworth BE, 2000, MED SCI SPORT EXER, V32, pS498, DOI 10.1097/00005768-200009001-00009
   [Anonymous], 2005, NAT ASS IR ZINC CALC
   Azar M, 1980, Food composition table of Iran: National Nutrition and Food Research Institute
   Azizi F, 2010, ARCH IRAN MED, V13, P426, DOI 010135/AIM.0011
   Azizi F, 2009, TRIALS, V10, DOI 10.1186/1745-6215-10-5
   Bo S, 2008, J NUTR, V138, P305, DOI 10.1093/jn/138.2.305
   Brown KH., 2000, ZINC HUMAN HLTH RESU
   Cai L, 2005, CURR MED CHEM, V12, P2753, DOI 10.2174/092986705774462950
   Ferns GAA, 1997, ATHEROSCLEROSIS, V133, P139, DOI 10.1016/S0021-9150(97)00130-5
   Ford ES, 2000, AM J EPIDEMIOL, V151, P1182, DOI 10.1093/oxfordjournals.aje.a010168
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Ghayour-Mobarhan M, 2009, J TRACE ELEM MED BIO, V23, P167, DOI 10.1016/j.jtemb.2009.03.006
   Ghayour-Mobarhan M, 2008, CLIN LAB, V54, P321
   Grattagliano I, 2008, J NUTR BIOCHEM, V19, P491, DOI 10.1016/j.jnutbio.2007.06.011
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Hänsch R, 2009, CURR OPIN PLANT BIOL, V12, P259, DOI 10.1016/j.pbi.2009.05.006
   Hennig B, 1999, J AM COLL NUTR, V18, P152, DOI 10.1080/07315724.1999.10718843
   Henning B, 2001, J AM COLL NUTR, V20, P97, DOI 10.1080/07315724.2001.10719021
   Hosseini-Esfahani F, 2010, METABOLISM, V59, P1833, DOI 10.1016/j.metabol.2010.06.013
   Hughes S, 2006, J AM COLL NUTR, V25, P285, DOI 10.1080/07315724.2006.10719537
   International Zinc Nutrition Consultative Group (IZiNCG), 2004, Food Nutr Bull, V25, pS99
   Isogawa A, 2009, DIABETES RES CLIN PR, V86, P213, DOI 10.1016/j.diabres.2009.09.007
   JIANG H, 1992, J AM COLL NUTR, V11, P74
   Karmaker S, 2007, MACROMOL BIOSCI, V7, P456, DOI 10.1002/mabi.200600227
   Koch KA, 1997, CHEM BIOL, V4, P549, DOI 10.1016/S1074-5521(97)90241-6
   KRISKA AM, 1990, DIABETES CARE, V13, P401, DOI 10.2337/diacare.13.4.401
   KROMHOUT D, 1985, AM J EPIDEMIOL, V122, P378, DOI 10.1093/oxfordjournals.aje.a114118
   Leone N, 2006, EPIDEMIOLOGY, V17, P308, DOI 10.1097/01.ede.0000209454.41466.b7
   Magálová T, 1999, NEOPLASMA, V46, P100
   MartinLagos F, 1997, SCI TOTAL ENVIRON, V204, P27, DOI 10.1016/S0048-9697(97)00163-0
   MEDEIROS D, 1983, LIFE SCI, V32, P1897, DOI 10.1016/0024-3205(83)90069-3
   Menuet R, 2005, AM J MED SCI, V330, P295, DOI 10.1097/00000441-200512000-00007
   Mirmiran P, 2010, PUBLIC HEALTH NUTR, V13, P654, DOI 10.1017/S1368980009991698
   Prasad AS, 2004, FREE RADICAL BIO MED, V37, P1182, DOI 10.1016/j.freeradbiomed.2004.07.007
   PRASAD AS, 1967, AM J CLIN NUTR, V20, P648, DOI 10.1093/ajcn/20.6.648
   Rastegarpanah M, 2008, ARCH IRAN MED, V11, P306, DOI 08113/AIM.0012
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Rose GBH, 1982, CARDIOVASCULAR SURVA
   Saari JT, 1999, J NUTR BIOCHEM, V10, P210, DOI 10.1016/S0955-2863(98)00100-4
   SAARI JT, 1992, P SOC EXP BIOL MED, V200, P19, DOI 10.3181/00379727-200-43388
   Singh RB, 1997, J AM COLL NUTR, V16, P62, DOI 10.1080/07315724.1997.10718650
   Singh RB, 1998, J AM COLL NUTR, V17, P564, DOI 10.1080/07315724.1998.10718804
   Sitasawad S, 2001, DIABETES RES CLIN PR, V52, P77, DOI 10.1016/S0168-8227(00)00249-7
   Songchitsomboon S, 1996, J Med Assoc Thai, V79, P550
   Sun Q, 2009, DIABETES CARE, V32, P629, DOI 10.2337/dc08-1913
   UMOREN J, 1989, ADV EXP MED BIOL, V258, P171
   World Health Organization, 1996, Trace Elements in Human Nutrition and Health
   World Health Organization, 2005, Preventing chronic diseases: a vital investment: WHO global report
NR 49
TC 7
Z9 7
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1446-6368
EI 1747-0080
J9 NUTR DIET
JI Nutr. Diet.
PD SEP
PY 2013
VL 70
IS 3
BP 218
EP 226
DI 10.1111/1747-0080.12026
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 227CN
UT WOS:000325085900009
OA Bronze
DA 2025-06-11
ER

PT J
AU Li, YR
   Guo, HW
   Liu, M
AF Li, Yanrong
   Guo, Hongwei
   Liu, Ming
TI Serum and dietary antioxidant status is associated with lower prevalence
   of the metabolic syndrome in a study in Shanghai, China
SO ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE human; antioxidant; serum; diet; metabolic syndrome
ID NUTRITION EXAMINATION SURVEY; OXIDATIVE STRESS MARKERS; 3RD
   NATIONAL-HEALTH; C-REACTIVE PROTEIN; INSULIN-RESISTANCE; RISK-FACTORS;
   INFLAMMATION; ADULTS; ZINC; FAT
AB Objective: The aim of our study was to examine the association between the metabolic syndrome (MS) and serum antioxidant status. Methods: A cross-sectional study was conducted with 221 cases and 329 controls aged 18 to 65 years. Weight, height, body mass index, waist circumference, blood pressure, fasting blood glucose and lipids, as well as serum superoxide dismutase, glutathione peroxidase, malondialdehide, vitamins A, E, beta-carotene and lycopene were examined. Intakes of antioxidants were also estimated. Results: Mean serum superoxide dismutase activity, beta-carotene concentrations were significantly lower, malondialdehide was higher (p<0.05) in persons with the MS (after adjusting for age, sex) than those without. Superoxide dismutase, glutathione peroxidase, and beta-carotene also decreased significantly (p<0.05) with increased number of components of the MS. Low levels of serum superoxide dismutase activity and beta-carotene concentration appeared to be associated with the MS status. Moreover, dietary energy, carbohydrate, vitamin C, zinc and copper intake in the MS patients were lower, but fat intake were higher. Vitamins E, C and manganese intake decreased with the elevated number of the MS components. For zinc and manganese, a lower risk was observed for other quartile of intake compared with the first one. Inverse links between dietary fat, energy intake and serum antioxidant status were found in MS patients, meanwhile dietary vitamin C was positively related with serum antioxidant level. Conclusions: Serum antioxidant status was associated with a lower prevalence of the MS, and with lower dietary fat, energy intake and higher vitamin C intake.
C1 [Li, Yanrong; Guo, Hongwei; Liu, Ming] Fudan Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Shanghai 200032, Peoples R China.
C3 Fudan University
RP Guo, HW (corresponding author), Fudan Univ, Sch Publ Hlth, Dept Nutr, 130 Dongan Rd, Shanghai 200032, Peoples R China.
EM hwguo@shmu.edu.cn
RI 刘, 明/HJG-8648-2022
FU Danone Dietary Nutrition for Research and Teaching
FX The study was funded by Danone Dietary Nutrition for Research and
   Teaching. There was no relationship that may pose a conflict of
   interest.
CR Abdilla N, 2007, J HUM HYPERTENS, V21, P68, DOI 10.1038/sj.jhh.1002105
   Armutcu F, 2008, CLIN CHEM LAB MED, V46, P785, DOI 10.1515/CCLM.2008.166
   Brandao-Neto J, 2000, BIOMETALS, V13, P141, DOI 10.1023/A:1009223105246
   Chen XR, 2009, NUTR METAB CARDIOVAS, V19, P27, DOI 10.1016/j.numecd.2008.01.010
   Demirbag R, 2006, INT J CLIN PRACT, V60, P1187, DOI 10.1111/j.1742-1241.2006.01042.x
   Devaraj S, 2008, METABOLISM, V57, P867, DOI 10.1016/j.metabol.2008.02.016
   Djousse L., 2010, Endocrine Metabolic & Immune Disorders-Drug Targets, V10, P124
   Esmaillzadeh A, 2007, AM J CLIN NUTR, V85, P910, DOI 10.1093/ajcn/85.3.910
   Esmaillzadeh A, 2006, AM J CLIN NUTR, V84, P1489, DOI 10.1093/ajcn/84.6.1489
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Fujita K, 2006, CIRC J, V70, P1437, DOI 10.1253/circj.70.1437
   Grundy SM, 2008, ARTERIOSCL THROM VAS, V28, P629, DOI 10.1161/ATVBAHA.107.151092
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Hopps E, 2010, NUTR METAB CARDIOVAS, V20, P72, DOI 10.1016/j.numecd.2009.06.002
   Isogawa A, 2009, DIABETES RES CLIN PR, V86, P213, DOI 10.1016/j.diabres.2009.09.007
   Kelishadi R, 2010, METAB SYNDR RELAT D, V8, P505, DOI 10.1089/met.2010.0020
   Koh KK, 2009, CARDIOVASC RES, V81, P649, DOI 10.1093/cvr/cvn354
   Lee KU, 2001, DIABETES RES CLIN PR, V54, pS29, DOI 10.1016/S0168-8227(01)00332-1
   Maury E, 2010, MOL CELL ENDOCRINOL, V314, P1, DOI 10.1016/j.mce.2009.07.031
   Paiva SAR, 1999, J AM COLL NUTR, V18, P426, DOI 10.1080/07315724.1999.10718880
   Paolisso G, 1999, EUR J CLIN INVEST, V29, P758
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Prasad AS, 2008, EXP GERONTOL, V43, P370, DOI 10.1016/j.exger.2007.10.013
   Puchau B, 2010, NUTRITION, V26, P534, DOI 10.1016/j.nut.2009.06.017
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Skalicky J, 2008, CLIN CHEM LAB MED, V46, P499, DOI 10.1515/CCLM.2008.096
   Sugiura M, 2008, BRIT J NUTR, V100, P1297, DOI 10.1017/S0007114508978302
   Suzuki A, 2010, INTERNAL MED, V49, P1, DOI 10.2169/internalmedicine.49.2689
   Willett WC, 1997, AM J CLIN NUTR, V65, P1220, DOI 10.1093/ajcn/65.4.1220S
   Yoo S, 2004, AM J CLIN NUTR, V80, P841, DOI 10.1093/ajcn/80.4.841
   Young IS, 2001, J CLIN PATHOL, V54, P176, DOI 10.1136/jcp.54.3.176
NR 33
TC 66
Z9 70
U1 0
U2 15
PU H E C PRESS, HEALTHY EATING CLUB PTY LTD
PI MCKINNON
PA PO BOX 4121, MCKINNON, VIC 3204, AUSTRALIA
SN 0964-7058
EI 1440-6047
J9 ASIA PAC J CLIN NUTR
JI Asia Pac. J. Clin. Nutr.
PY 2013
VL 22
IS 1
BP 60
EP 68
DI 10.6133/apjcn.2013.22.1.06
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 158ZU
UT WOS:000320014600009
PM 23353612
DA 2025-06-11
ER

PT J
AU Sikora, J
   Broncel, M
   Markowicz, M
   Chalubinski, M
   Wojdan, K
   Mikiciuk-Olasik, E
AF Sikora, Joanna
   Broncel, Marlena
   Markowicz, Magdalena
   Chalubinski, Maciej
   Wojdan, Katarzyna
   Mikiciuk-Olasik, Elzbieta
TI Short-term supplementation with Aronia melanocarpa extract
   improves platelet aggregation, clotting, and fibrinolysis in patients
   with metabolic syndrome
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Aronia; Coagulation; Fibrinolysis; Metabolic syndrome; Platelet
   aggregation
ID BLOOD-PRESSURE; OXIDATIVE STRESS; CONSUMPTION; PARAMETERS; PLASMA; JUICE
AB A diet rich in berries is believed to play a distinct role in the prevention of metabolic diseases associated with obesity. So far, there have been no published clinical observations evaluating the influence of Aronia melanocarpa on hemostasis. The aim of our study was to investigate the effects of A. melanocarpa extract (AM) supplementation on platelet aggregation, clot formation, and lysis in patients with metabolic syndrome (MS).
   Middle-aged non-medicated subjects with MS (n = 38) and 14 healthy volunteers were included in this study. Patients with MS were treated with 100 mg of AM three times daily for 2 months.
   We observed a significant reduction in the concentration of TC, LDL-C, and TG after AM supplementation. Beneficial changes in coagulation parameters were also observed. After 1 month of AM administration, we noticed significant inhibition of platelet aggregation. However, this effect became less pronounced after 2 months of supplementation. In the case of coagulation induced by endogenic thrombin, a significant decrease in the overall potential for coagulation was induced after 1 or 2 months of supplementation. Moreover, after 1 month of AM extract supplementation, we observed a beneficial reduction in the overall potential for clot formation and fibrinolysis.
   We observed the normalization of hemostasis parameters in MS patients after both 1 and 2 months of AM administration. After 1 month of AM supplementation, we found favorable changes in regards to the overall potential for plasma clotting, clot formation, and lysis, as well as in the lipid profiles of subjects.
C1 [Sikora, Joanna; Markowicz, Magdalena; Mikiciuk-Olasik, Elzbieta] Med Univ Lodz, Dept Pharmaceut Chem & Drug Anal, PL-90151 Lodz, Poland.
   [Broncel, Marlena; Chalubinski, Maciej; Wojdan, Katarzyna] Med Univ Lodz, Dept Internal Dis & Clin Pharmacol, PL-91347 Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz
RP Sikora, J (corresponding author), Med Univ Lodz, Dept Pharmaceut Chem & Drug Anal, Muszynskiego 1, PL-90151 Lodz, Poland.
EM joanna.sikora@umed.lodz.pl
RI Sikora, Joanna/J-5197-2012; Mikiciuk-Olasik, Elzbieta/D-5091-2011;
   Markowicz-Piasecka, Magdalena/S-6673-2016
OI Mikiciuk-Olasik, Elzbieta/0000-0002-7171-4524; Broncel,
   Marlena/0000-0003-3659-8115; Sikora, Joanna/0000-0001-7044-9696;
   Markowicz-Piasecka, Magdalena/0000-0002-1012-6550; Chalubinski,
   Maciej/0000-0001-8311-9530
FU Polish Ministry of Science and Higher Education [N N405 062934]
FX This study was supported by project N N405 062934 of the Polish Ministry
   of Science and Higher Education.
CR Antovic A, 2010, SEMIN THROMB HEMOST, V36, P772, DOI 10.1055/s-0030-1265294
   Broncel M, 2010, MED SCI MONITOR, V16, pCR28
   Cefalu WT, 2008, AM J CLIN NUTR, V87, p481S, DOI 10.1093/ajcn/87.2.481S
   CLAUSS A., 1957, ACTA HAEMATOL, V17, P237
   De Pergola G, 2002, J ENDOCRINOL INVEST, V25, P899, DOI 10.1007/BF03344054
   Erlund I, 2008, AM J CLIN NUTR, V87, P323, DOI 10.1093/ajcn/87.2.323
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Jablonska-Trypuc A., 2007, PRZ KARDIODIABETOL C, V2, P253
   Kedzierska M, 2011, PLATELETS
   Kokotkiewicz A, 2010, J MED FOOD, V13, P255, DOI 10.1089/jmf.2009.0062
   Kostka B, 2007, BLOOD COAGUL FIBRIN, V18, P611, DOI 10.1097/MBC.0b013e3282ddeb19
   Kostka B, 2007, BLOOD COAGUL FIBRIN, V18, P151, DOI 10.1097/MBC.0b013e3280147feb
   Koziróg M, 2011, J PINEAL RES, V50, P261, DOI 10.1111/j.1600-079X.2010.00835.x
   Luzak B, 2010, ARCH MED SCI, V6, P141, DOI 10.5114/aoms.2010.13884
   Mckay DL, 2007, NUTR REV, V65, P490, DOI 10.1301/nr.2007.nov.490-502
   Naruszewicz M, 2007, ATHEROSCLEROSIS, V194, pE179, DOI 10.1016/j.atherosclerosis.2006.12.032
   Olas B, 2008, PLATELETS, V19, P70, DOI 10.1080/09537100701708506
   Ouchi N, 1999, CIRCULATION, V100, P2473, DOI 10.1161/01.CIR.100.25.2473
   Para J, 2007, THESIS MED U LODZ
   Sikora J., 2009, BROMAT CHEM TOSKYKOL, V1, P10
   Skoczynska A, 2007, PHARMACOL REP, V59, P177
   Tsuda T, 2008, J AGR FOOD CHEM, V56, P642, DOI 10.1021/jf073113b
   Vachleva-Kuzmanova SV, 2006, FOLIA MED, VXLVIII, P11
   Wilson T, 2001, FASEB J, V15, pA286
   Wróblewska M, 2008, ACTA ALIMENT HUNG, V37, P221, DOI 10.1556/AAlim.37.2008.2.8
NR 25
TC 61
Z9 62
U1 0
U2 27
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD AUG
PY 2012
VL 51
IS 5
BP 549
EP 556
DI 10.1007/s00394-011-0238-8
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 975XI
UT WOS:000306544600004
PM 21850495
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Chakravarthy, MV
   Zhu, Y
   Yin, L
   Coleman, T
   Pappan, KL
   Marshall, CA
   McDaniel, ML
   Semenkovich, CF
AF Chakravarthy, Manu V.
   Zhu, Yimin
   Yin, Li
   Coleman, Trey
   Pappan, Kirk L.
   Marshall, Connie A.
   McDaniel, Michael L.
   Semenkovich, Clay F.
TI Inactivation of hypothalamic FAS protects mice from diet-induced obesity
   and inflammation
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE metabolic syndrome; insulin resistance; type 2 diabetes mellitus
ID INDUCED INSULIN-RESISTANCE; ACTIVATES PPAR-ALPHA; FATTY-ACID OXIDATION;
   ADIPOSE-TISSUE; METABOLIC SYNDROME; SKELETAL-MUSCLE; GLUCOSE-METABOLISM;
   MALONYL-COA; FOOD-INTAKE; BETA
AB Obesity promotes insulin resistance and chronic inflammation. Disrupting any of several distinct steps in lipid synthesis decreases adiposity, but it is unclear if this approach coordinately corrects the environment that propagates metabolic disease. We tested the hypothesis that inactivation of FAS in the hypothalamus prevents diet-induced obesity and systemic inflammation. Ten weeks of high-fat feeding to mice with inactivation of FAS (FASKO) limited to the hypothalamus and pancreatic beta cells protected them from diet-induced obesity. Though high-fat fed FASKO mice had no beta-cell phenotype, they were hypophagic and hypermetabolic, and they had increased insulin sensitivity at the liver but not the periphery as demonstrated by hyperinsulinemic-euglycemic clamps, and biochemically by increased phosphorylated Akt, glycogen synthase kinase-3beta, and FOXO1 compared with wild-type mice. High-fat fed FASKO mice had decreased excretion of urinary isoprostanes, suggesting less oxidative stress and blunted tumor necrosis factor alpha (TNF alpha) and interleukin-6 (IL-6) responses to endotoxin, suggesting less systemic inflammation. Pair-feeding studies demonstrated that these beneficial effects were dependent on central FAS disruption and not merely a consequence of decreased adiposity. Thus, inducing central FAS deficiency may be a valuable integrative strategy for treating several components of the metabolic syndrome, in part by correcting hepatic insulin resistance and suppressing inflammation.-Chakravarthy, M. V., Y. Zhu, L. Yin, T. Coleman, K. L. Pappan, C. A. Marshall, M. L. McDaniel, and C. F. Semenkovich. Inactivation of hypothalamic FAS protects mice from diet-induced obesity and inflammation. J. Lipid Res. 2009. 50: 630-640.
C1 [Chakravarthy, Manu V.; Zhu, Yimin; Yin, Li; Coleman, Trey; Semenkovich, Clay F.] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA.
   [Pappan, Kirk L.; Marshall, Connie A.; McDaniel, Michael L.] Washington Univ, Sch Med, Dept Pathol & Immunol, Div Endocrinol Metab & Lipid, St Louis, MO 63110 USA.
   [Semenkovich, Clay F.] Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA.
C3 Washington University (WUSTL); Washington University (WUSTL); Washington
   University (WUSTL)
RP Semenkovich, CF (corresponding author), Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA.
EM csemenko@wustl.edu
RI Pappan, Kirk/AAV-5946-2021; Chakravarthy, Manu/AAD-7553-2021;
   Segura-Aguilar, Juan/H-8839-2013
OI Semenkovich, Clay/0000-0003-1163-1871; Pappan, Kirk/0000-0002-2341-8798
FU American Diabetes Association [1-07-JF-12]; Mentor-Based Postdoctoral
   Fellowship Award; National Institutes of Health [DK076729, P50
   HL083762]; Clinical Nutrition Research Unit [DK56341]; Diabetes Research
   and Training Center [DK20579]
FX This work was supported by the American Diabetes Association ( Junior
   Faculty Award 1-07-JF-12 to MVC and a Mentor-Based Postdoctoral
   Fellowship Award), National Institutes of Health grants DK076729 and P50
   HL083762, and the Clinical Nutrition Research Unit (DK56341) and
   Diabetes Research and Training Center (DK20579).
CR Abu-Elheiga L, 2003, P NATL ACAD SCI USA, V100, P10207, DOI 10.1073/pnas.1733877100
   ABUMRAD NA, 1993, J BIOL CHEM, V268, P17665
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Bernal-Mizrachi C, 2005, NATURE, V435, P502, DOI 10.1038/nature03527
   Bernal-Mizrachi C, 2007, CELL METAB, V5, P91, DOI 10.1016/j.cmet.2006.12.010
   Borovikova LV, 2000, NATURE, V405, P458, DOI 10.1038/35013070
   Bradley MN, 2007, J CLIN INVEST, V117, P2337, DOI 10.1172/JCI31909
   Brun T, 1996, DIABETES, V45, P190, DOI 10.2337/diabetes.45.2.190
   Cha SH, 2005, P NATL ACAD SCI USA, V102, P14557, DOI 10.1073/pnas.0507300102
   Chakravarthy MV, 2007, J CLIN INVEST, V117, P2539, DOI 10.1172/JCI31183
   Chakravarthy MV, 2005, CELL METAB, V1, P309, DOI 10.1016/j.cmet.2005.04.002
   Chari M, 2008, DIABETES, V57, P836, DOI 10.2337/db07-1464
   Chen C, 2008, CELL METAB, V7, P135, DOI 10.1016/j.cmet.2007.12.003
   Chen HC, 2003, J CLIN INVEST, V111, P1715, DOI 10.1172/JCI200315859
   Du KY, 2003, SCIENCE, V300, P1574, DOI 10.1126/science.1079817
   Flowers JB, 2007, DIABETES, V56, P1228, DOI 10.2337/db06-1142
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   Gates AC, 2007, CELL METAB, V6, P497, DOI 10.1016/j.cmet.2007.10.010
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Hu ZY, 2005, J BIOL CHEM, V280, P39681, DOI 10.1074/jbc.C500398200
   Inoue M, 2005, BIOCHEM BIOPH RES CO, V336, P215, DOI 10.1016/j.bbrc.2005.08.070
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jones JR, 2005, P NATL ACAD SCI USA, V102, P6207, DOI 10.1073/pnas.0306743102
   Kalaany NY, 2005, CELL METAB, V1, P231, DOI 10.1016/j.cmet.2005.03.001
   Kanda H, 2006, J CLIN INVEST, V116, P1494, DOI 10.1172/JCI26498
   Kim JY, 2007, J CLIN INVEST, V117, P2621, DOI 10.1172/JCI31021
   Lee JY, 2006, J BIOL CHEM, V281, P2649, DOI 10.1074/jbc.M512373200
   Li B, 2000, NAT MED, V6, P1115, DOI 10.1038/80450
   Li ZP, 2005, SURG CLIN N AM, V85, P681, DOI 10.1016/j.suc.2005.04.006
   Lumeng CN, 2007, J CLIN INVEST, V117, P175, DOI 10.1172/JCI29881
   Ntambi JM, 2002, P NATL ACAD SCI USA, V99, P11482, DOI 10.1073/pnas.132384699
   Obici S, 2003, NAT MED, V9, P756, DOI 10.1038/nm873
   Ogden CL, 2006, JAMA-J AM MED ASSOC, V295, P1549, DOI 10.1001/jama.295.13.1549
   Pappan KL, 2005, J BIOL CHEM, V280, P9023, DOI 10.1074/jbc.M409706200
   Petersen EW, 2005, AM J PHYSIOL-ENDOC M, V288, pE155, DOI 10.1152/ajpendo.00257.2004
   Pocai A, 2006, J CLIN INVEST, V116, P1081, DOI 10.1172/JCI26640
   Rector RS, 2008, AM J PHYSIOL-GASTR L, V294, pG619, DOI 10.1152/ajpgi.00428.2007
   Rösen P, 2001, DIABETES-METAB RES, V17, P189, DOI 10.1002/dmrr.196
   Semenkovich CF, 1997, PROG LIPID RES, V36, P43, DOI 10.1016/S0163-7827(97)00003-9
   Shi H, 2006, J CLIN INVEST, V116, P3015, DOI 10.1172/JCI28898
   Shimomura I, 1999, J BIOL CHEM, V274, P30028, DOI 10.1074/jbc.274.42.30028
   Shimomura L, 1999, P NATL ACAD SCI USA, V96, P13656, DOI 10.1073/pnas.96.24.13656
   Um SH, 2004, NATURE, V431, P200, DOI 10.1038/nature02866
   Wang YX, 2003, CELL, V113, P159, DOI 10.1016/S0092-8674(03)00269-1
   Weir GC, 2004, DIABETES, V53, pS16, DOI 10.2337/diabetes.53.suppl_3.S16
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yuan MS, 2001, SCIENCE, V293, P1673, DOI 10.1126/science.1061620
NR 50
TC 36
Z9 45
U1 0
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD APR
PY 2009
VL 50
IS 4
BP 630
EP 640
DI 10.1194/jlr.M800379-JLR200
PG 11
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 420IV
UT WOS:000264283800005
PM 19029118
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Shan, SH
   Yin, RP
   Shi, JY
   Zhang, LZ
   Zhou, JQ
   Qiao, QQ
   Dong, XS
   Zhao, WJ
   Li, ZY
AF Shan, Shuhua
   Yin, Ruopeng
   Shi, Jiangying
   Zhang, Lizhen
   Zhou, Jiaqi
   Qiao, Qinqin
   Dong, Xiushan
   Zhao, Wenjing
   Li, Zhuoyu
TI Gut microbiota remodeling drived by dietary millet protein prevents the
   metabolic syndrome
SO FOOD SCIENCE AND HUMAN WELLNESS
LA English
DT Article
DE Metabolic syndrome; Gut microbiota; Extract of millet bran protein;
   Gamma-aminobutyric acid; Gut barrier function
ID OXYGEN-GLUCOSE DEPRIVATION; HIGH-FAT DIET; OXIDATIVE STRESS; OBESITY;
   INFLAMMATION; DYSFUNCTION; WEIGHT; HEALTH
AB Metabolic syndrome (MetS) is a chronic disease associated with the disturbance of gut microbiota homeostasis. Metabolites derived from gut microbes play essential roles in MetS prevention and therapy. Here, we focused on the inhibitory effect of the extract of millet bran protein (EMBP) on a high -fat diet (HFD)induced MetS, aiming to identify gut microbiota and their metabolites that involve in the anti-MetS activity of EMBP. The obesity, chronic inflammation, insulin resistance in MetS mouse models were abolished after EMBP treatment. The protective mechanism of EMBP against HFD-induced MetS may depend on improved gut barrier function. Using microbiome analysis, we found that EMBP supplementation improved gut microbiome dysbiosis in MetS mice, specifically upregulating Bacteroides acidifaciens . The fecal microbiota transplantation (FMT) also demonstrated this phenomenon. In addition, metabolomic analysis showed that EMBP mediates metabolic profiling reprogramming in MetS mice. Notably, a microbiota-derived metabolite, gamma-aminobutyric acid (GABA), is enriched by EMBP. In addition, exogenous GABA treatment produced a similar protective effect to EMBP by improving NRF2-dependent gut barrier function to protect HFDinduced MetS. The results suggest that EMBP suppress host MetS by remodeling of gut microbiota as an effective candidate for next -generation medicine food dual purpose dietary supplement to intervene in MetS. (c) 2024 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Shan, Shuhua; Zhou, Jiaqi; Qiao, Qinqin; Li, Zhuoyu] Shanxi Univ, Inst Biotechnol, Key Lab Chem Biol & Mol Engn, Natl Minist Educ, Taiyuan 030006, Peoples R China.
   [Zhang, Lizhen] Shanxi Univ, Sch Life Sci, Taiyuan 030006, Peoples R China.
   [Dong, Xiushan] Shanxi Med Univ, Shanxi Bethune Hosp, Tongji Shanxi Hosp, Hosp 3,Shanxi Acad Med Sci, Taiyuan 030032, Peoples R China.
   [Zhao, Wenjing] Taiyuan Normal Univ, Biol Sci & Technol Coll, Dept Biol, Jinzhong 030619, Peoples R China.
C3 Shanxi University; Shanxi University; Shanxi Medical University; Taiyuan
   Normal University
RP Shan, SH; Li, ZY (corresponding author), Shanxi Univ, Inst Biotechnol, Key Lab Chem Biol & Mol Engn, Natl Minist Educ, Taiyuan 030006, Peoples R China.
EM ssh@sxu.edu.cn; lzy@sxu.edu.cn
RI Shan, Shuhua/MZR-6507-2025; Zhuoyu, Li/GXZ-8401-2022
FU National Natural Science Foundation of China [32270420, 32072220];
   National Key Research and Development Project [2020YFD1001405]; Shanxi
   Province Science Foundation [202103021224011]; Shanxi Key Laboratory for
   Research and Development of Regional Plants; Shanxi Province "136"
   Revitalization Medical Project Construction Funds
FX The authors gratefully acknowledge China Institute of Radiation
   Protection for providing animal care facility; the technical support by
   the Servicebio Co., Ltd. is also appreciated; the sequencing and
   bioinformatics analysis are provided by Personal Co., Ltd., Biotree Co.,
   Ltd. and Novogene Co., Ltd.; the elements provided by Figdraw for
   Graphical abstract are referenced.This study was supported by National
   Natural Science Foundation of China (32270420, 32072220), National Key
   Research and Development Project (2020YFD1001405), Shanxi Province
   Science Foundation (202103021224011), Shanxi Key Laboratory for Research
   and Development of Regional Plants, Shanxi Province "136" Revitalization
   Medical Project Construction Funds.
CR Anhê FF, 2019, GUT, V68, P453, DOI 10.1136/gutjnl-2017-315565
   Anhê FF, 2015, GUT, V64, P872, DOI 10.1136/gutjnl-2014-307142
   Aron-Wisnewsky J, 2021, GASTROENTEROLOGY, V160, P573, DOI 10.1053/j.gastro.2020.10.057
   Bajic SS, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.00527
   Blüher M, 2019, NAT REV ENDOCRINOL, V15, P288, DOI 10.1038/s41574-019-0176-8
   Moreira APB, 2012, BRIT J NUTR, V108, P801, DOI 10.1017/S0007114512001213
   Bovolini A, 2021, INT J SPORTS MED, V42, P199, DOI 10.1055/a-1263-0898
   Brückner M, 2012, J CROHNS COLITIS, V6, P226, DOI 10.1016/j.crohns.2011.08.012
   Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
   Camilleri M, 2019, GUT, V68, P1516, DOI 10.1136/gutjnl-2019-318427
   Chao AM, 2021, J CLIN INVEST, V131, DOI 10.1172/JCI140065
   Hersoug LG, 2018, NUTR RES REV, V31, P153, DOI [10.1017/S0954422417000269, 10.1017/s0954422417000269]
   Jaacks LM, 2019, LANCET DIABETES ENDO, V7, P231, DOI 10.1016/S2213-8587(19)30026-9
   Khoruts A, 2018, GENOME MED, V10, DOI 10.1186/s13073-018-0592-8
   Liu RX, 2017, NAT MED, V23, P859, DOI 10.1038/nm.4358
   Liu XM, 2022, NAT GENET, V54, P52, DOI 10.1038/s41588-021-00968-y
   Luger M, 2013, EXP CLIN ENDOCR DIAB, V121, P286, DOI 10.1055/s-0033-1341472
   Magne F, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051474
   Miyamoto Y, 2000, INT J SYST EVOL MICR, V50, P145, DOI 10.1099/00207713-50-1-145
   Munukka E, 2017, ISME J, V11, P1667, DOI 10.1038/ismej.2017.24
   Neis EPJG, 2015, NUTRIENTS, V7, P2930, DOI 10.3390/nu7042930
   Pan XF, 2019, LANCET DIABETES ENDO, V7, P502, DOI 10.1016/S2213-8587(19)30159-7
   Plovier H, 2017, NAT MED, V23, P107, DOI 10.1038/nm.4236
   Quan LH, 2020, GUT, V69, P1239, DOI 10.1136/gutjnl-2019-319114
   Quast C, 2013, NUCLEIC ACIDS RES, V41, pD590, DOI 10.1093/nar/gks1219
   Rohr MW, 2020, ADV NUTR, V11, P77, DOI 10.1093/advances/nmz061
   Sachdev N, 2021, J SCI FOOD AGR, V101, P831, DOI 10.1002/jsfa.10716
   Saeedi BJ, 2020, CELL METAB, V31, P956, DOI 10.1016/j.cmet.2020.03.006
   Sanna S, 2019, NAT GENET, V51, P600, DOI 10.1038/s41588-019-0350-x
   Shan SH, 2022, J AGR FOOD CHEM, V70, P507, DOI 10.1021/acs.jafc.1c05747
   Shan SH, 2020, J AGR FOOD CHEM, V68, P8295, DOI 10.1021/acs.jafc.0c03257
   Shan SH, 2014, TOXICOL LETT, V227, P129, DOI 10.1016/j.toxlet.2014.03.008
   Shannon P, 2003, GENOME RES, V13, P2498, DOI 10.1101/gr.1239303
   Shirouchi B, 2019, J OLEO SCI, V68, P517, DOI 10.5650/jos.ess19084
   Singh R, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-018-07859-7
   Strandwitz P, 2019, NAT MICROBIOL, V4, P396, DOI 10.1038/s41564-018-0307-3
   Su XM, 2022, MICROBIOME, V10, DOI 10.1186/s40168-021-01205-8
   Sun WL, 2021, CELL REP, V36, DOI 10.1016/j.celrep.2021.109641
   Suzumura EA, 2019, NUTR REV, V77, P430, DOI 10.1093/nutrit/nuz001
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Wang K, 2019, CELL REP, V26, P222, DOI 10.1016/j.celrep.2018.12.028
   Wang YX, 2020, P NATL ACAD SCI USA, V117, P8431, DOI 10.1073/pnas.1916189117
   Wei H, 2022, ECOTOX ENVIRON SAFE, V230, DOI 10.1016/j.ecoenv.2021.113150
   Wu SJ, 2022, NUTRIENTS, V14, DOI 10.3390/nu14030453
   Wu TR, 2019, GUT, V68, P248, DOI 10.1136/gutjnl-2017-315458
   Xu JH, 2020, J DIABETES, V12, P224, DOI 10.1111/1753-0407.12986
   Xu Y, 2020, THERANOSTICS, V10, P11302, DOI 10.7150/thno.47746
   Yang JY, 2017, MUCOSAL IMMUNOL, V10, P104, DOI 10.1038/mi.2016.42
   Yang M, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9121893
   Yogeswara IBA, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8121923
   Yoo W, 2021, SCIENCE, V373, P813, DOI 10.1126/science.aba3683
   Yu EW, 2020, PLOS MED, V17, DOI 10.1371/journal.pmed.1003051
   Zhang XY, 2020, GUT MICROBES, V12, DOI 10.1080/19490976.2020.1842990
   Zhang YS, 2022, MOL CELL, V82, P1528, DOI 10.1016/j.molcel.2022.01.021
   Zhou Y, 2015, J MOL NEUROSCI, V55, P941, DOI 10.1007/s12031-014-0449-6
   Zhou YC, 2015, INT J MOL MED, V36, P43, DOI 10.3892/ijmm.2015.2205
   Zhu F, 2021, INT IMMUNOPHARMACOL, V101, DOI 10.1016/j.intimp.2021.108221
   Zou J, 2021, CELL MOL GASTROENTER, V12, P983, DOI 10.1016/j.jcmgh.2021.04.014
NR 58
TC 2
Z9 2
U1 9
U2 28
PU TSINGHUA UNIV PRESS
PI BEIJING
PA B605D, XUE YAN BUILDING, BEIJING, 100084, PEOPLES R CHINA
EI 2213-4530
J9 FOOD SCI HUM WELL
JI Food Sci. Human Wellness
PD JUL
PY 2024
VL 13
IS 4
BP 1987
EP 2001
DI 10.26599/FSHW.2022.9250165
PG 15
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA UC0Z1
UT WOS:001245757900001
OA gold
DA 2025-06-11
ER

PT J
AU Baghery, F
   Mohammadifard, N
   Falahati-Pour, SK
AF Baghery, Fatemeh
   Mohammadifard, Noushin
   Falahati-Pour, Soudeh Khanamani
TI The effect of pistachio supplementation on metabolic syndrome and its
   components in adults: a systematic review and meta-analysis of
   randomized controlled trials
SO NUTRITION REVIEWS
LA English
DT Review
DE metabolic syndrome; meta-analysis; pistachio; systematic review
ID NUT CONSUMPTION; ENDOTHELIAL FUNCTION; BLOOD-PRESSURE; INFLAMMATION;
   PARAMETERS; PROFILE; STRESS
AB Context Several observational and experimental studies have been conducted to evaluate the effects of pistachio intake on metabolic syndrome (MetS); however, the results are inconsistent. Objective This systematic review and meta-analysis were performed on data from randomized controlled trials (RCTs) to determine the effect of pistachio consumption on MetS components. Data sources The PubMed, Scopus, Google Scholar and Web of Science databases were searched from 1986 to 2021. Study selection English-language RCTs on pistachio intake were included that provided outcomes on hypertension, hyperglycemia, hypertriglyceridemia, and high-density lipoprotein (HDL). Data extraction Results are presented as pooled mean differences (MDs) between intervention and control groups with 95%CI reported for each of the components. Results Seventeen RCTs including 940 adults met the inclusion criteria for this systematic review and meta-analysis. Pistachio supplementation significantly reduced systolic blood pressure (BP; MD, -2.89 mmHg, 95%CI: -4.11 to -1.67; P < 0.001), triglycerides (MD, -16.76 mg/dL, 95%CI: -16.89 to -16.64; P < 0.001), fasting blood glucose (MD, -3.62 mg/dL, 95%CI: -6.45 to -0.8; P < 0.001,) and increased HDL (MD, 1.43 mg/dL, 95%CI: 1.39 to 1.47; P < 0.001) levels. However, there were not observed considerable changes in waist circumference, diastolic BP, and body mass index. Conclusion The results of this research show that pistachio consumption could improve some MetS components, including systolic blood pressure, triglyceride, fasting blood glucose, and HDL levels, without affecting anthropometric indices and diastolic BP.
C1 [Baghery, Fatemeh; Falahati-Pour, Soudeh Khanamani] Rafsanjan Univ Med Sci, Pistachio Safety Res Ctr, POB 77177735979, Rafsanjan, Iran.
   [Mohammadifard, Noushin] Isfahan Univ Med Sci, Cardiovasc Res Inst, Isfahan Cardiovasc Res Ctr, Esfahan, Iran.
C3 Isfahan University of Medical Sciences
RP Falahati-Pour, SK (corresponding author), Rafsanjan Univ Med Sci, Pistachio Safety Res Ctr, POB 77177735979, Rafsanjan, Iran.
EM S.falahatipour@rums.ac.ir
RI Merat, Shahin/A-5478-2009; Falahati, Soudeh/M-3678-2017
CR Abdoshahi A., 2011, International Journal of Nuts and Related Sciences (IJNRS), V2, P15
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Aldemir M, 2011, INT J IMPOT RES, V23, P32, DOI 10.1038/ijir.2010.33
   Allen LH, 2008, J NUTR, V138, p1763S, DOI 10.1093/jn/138.9.1763S
   Asbaghi O, 2021, BRIT J NUTR, V126, P718, DOI 10.1017/S0007114520004523
   Bagheri F., 2021, PHJ, V4, P1
   Balduzzi S, 2019, EVID-BASED MENT HEAL, V22, P153, DOI 10.1136/ebmental-2019-300117
   BodeBoger SM, 1996, CIRCULATION, V93, P85, DOI 10.1161/01.CIR.93.1.85
   Carughi A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11040767
   Cumpston MS, Cochrane Handbook for Systematic Reviews of Interventions Version 6.0
   Delavar MA, 2009, ASIA PAC J CLIN NUTR, V18, P285
   Dreher ML, 2012, NUTR REV, V70, P234, DOI 10.1111/j.1753-4887.2011.00467.x
   Esmaeili Nadimi Ali, 2020, Int J Vitam Nutr Res, V90, P564, DOI 10.1024/0300-9831/a000529
   Gebauer SK, 2008, AM J CLIN NUTR, V88, P651, DOI 10.1093/ajcn/88.3.651
   Gulati S, 2014, NUTRITION, V30, P192, DOI 10.1016/j.nut.2013.08.005
   Harandi H, 2018, ASIAN PAC J TROP BIO, V8, P598, DOI 10.4103/2221-1691.248097
   Hernandez-Alonso Pablo, 2016, Nutr Today, V51, P133, DOI 10.1097/NT.0000000000000160
   Hernández-Alonso P, 2014, DIABETES CARE, V37, P3098, DOI 10.2337/dc14-1431
   Higgins JPT, 2011, BMJ-BRIT MED J, V343, DOI 10.1136/bmj.d5928
   Kasliwal RR, 2015, NUTRITION, V31, P678, DOI 10.1016/j.nut.2014.10.019
   Kay CD, 2010, J NUTR, V140, P1093, DOI 10.3945/jn.109.117366
   Kazankaya A, 2008, ASIAN J CHEM, V20, P2344
   Khanamani Falahati-pour S., 2019, Pistachio and Health Journal, V2, P4
   Kocyigit A, 2006, NUTR METAB CARDIOVAS, V16, P202, DOI 10.1016/j.numecd.2005.08.004
   Li H, 2018, NUTR METAB, V15, DOI 10.1186/s12986-018-0282-y
   Li ZP, 2010, J AM COLL NUTR, V29, P198, DOI 10.1080/07315724.2010.10719834
   Lippi Giuseppe, 2016, Acta Biomed, V87, P5
   Liu YT, 2014, J AGR FOOD CHEM, V62, P1550, DOI 10.1021/jf4046864
   London HA, 2013, AM J LIFESTYLE MED, V7, P274, DOI 10.1177/1559827613479910
   Mejia SB, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2013-004660
   Mohamadi M., 2019, PHJ, V2, P1
   Mohammadifard N, 2015, AM J CLIN NUTR, V101, P966, DOI 10.3945/ajcn.114.091595
   Moher D, 2009, PHYS THER, V89, P873, DOI 10.1093/ptj/89.9.873
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Parham Mahmoud, 2014, Rev Diabet Stud, V11, P190, DOI 10.1900/RDS.2014.11.190
   Rock CL, 2020, NUTRIENTS, V12, DOI 10.3390/nu12072155
   Ros E, 2010, CURR ATHEROSCLER REP, V12, P397, DOI 10.1007/s11883-010-0132-5
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Salas-Salvadó J, 2014, AM J CLIN NUTR, V100, p399S, DOI 10.3945/ajcn.113.071530
   Sari I, 2010, NUTRITION, V26, P399, DOI 10.1016/j.nut.2009.05.023
   Sauder KA, 2015, METABOLISM, V64, P1521, DOI 10.1016/j.metabol.2015.07.021
   Sauder KA, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.114.000873
   Sheridan MJ, 2007, J AM COLL NUTR, V26, P141, DOI 10.1080/07315724.2007.10719595
   Wang X, 2012, NUTR J, V11, DOI 10.1186/1475-2891-11-20
   West SG, 2012, HYPERTENSION, V60, P58, DOI 10.1161/HYPERTENSIONAHA.111.182147
   Wilson TYJ., 2014, International Journal of Food and Nutritional Science, V1, P1
NR 46
TC 7
Z9 7
U1 4
U2 11
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD SEP 5
PY 2022
VL 80
IS 10
BP 2051
EP 2063
DI 10.1093/nutrit/nuac027
EA JUN 2022
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 4K0BG
UT WOS:000809430600001
PM 35689651
OA Bronze
DA 2025-06-11
ER

PT J
AU Cheng, CH
   Lin, CY
   Cho, TH
   Lin, CM
AF Cheng, Chao-Hsin
   Lin, Ching-Yuan
   Cho, Tsung-Hsun
   Lin, Chih-Ming
TI Machine Learning to Predict the Progression of Bone Mass Loss Associated
   with Personal Characteristics and a Metabolic Syndrome Scoring Index
SO HEALTHCARE
LA English
DT Article
DE osteopenia; metabolic syndrome; socioeconomic status; lifestyle; machine
   learning
ID ARTIFICIAL NEURAL-NETWORKS; MINERAL DENSITY; RISK-FACTORS; HEALTH; HIP;
   CALCIFICATION; FRACTURE; STRESS; ADULTS; KOREA
AB A relationship exists between metabolic syndrome (MetS) and human bone health; however, whether the combination of demographic, lifestyle, and socioeconomic factors that are associated with MetS development also simultaneously affects bone density remains unclear. Using a machine learning approach, the current study aimed to estimate the usefulness of predicting bone mass loss using these potentially related factors. The present study included a sample of 23,497 adults who routinely visited a health screening center at a large health center at least once during each of three 3-year stages (i.e., 2006-2008, 2009-2011, and 2012-2014). The demographic, socioeconomic, lifestyle characteristics, body mass index (BMI), and MetS scoring index recorded during the first 3-year stage were used to predict the subsequent occurrence of osteopenia using a non-concurrence design. A concurrent prediction was also performed using the features recorded from the same 3-year stage as the predicted outcome. Machine learning algorithms, including logistic regression (LR), support vector machine (SVM), random forest (RF), and extreme gradient boosting (XGBoost), were applied to build predictive models using a unique feature set. The area under the receiver operating characteristic curve (AUC), accuracy, sensitivity, specificity, precision, and F1 score were used to evaluate the predictive performances of the models. The XGBoost model presented the best predictive performance among the non-concurrence models. This study suggests that the ensemble learning model with a MetS severity score can be used to predict the progression of osteopenia. The inclusion of an individual's features into a predictive model over time is suggested for future studies.
C1 [Cheng, Chao-Hsin] Ten Chan Gen Hosp, Div Chest Med, Taoyuan 320, Taiwan.
   [Lin, Ching-Yuan] Ten Chan Gen Hosp, Dept Lab Med, Taoyuan 320, Taiwan.
   [Cho, Tsung-Hsun] Natl Yang Ming Chiao Tung Univ, Inst Biomed Informat, Taipei 112, Taiwan.
   [Lin, Chih-Ming] Ming Chum Univ, Dept Healthcare Informat & Management, Taoyuan 333, Taiwan.
C3 National Yang Ming Chiao Tung University
RP Lin, CM (corresponding author), Ming Chum Univ, Dept Healthcare Informat & Management, Taoyuan 333, Taiwan.
EM starcheng2001@gmail.com; lab02@tcmg.com.tw; eric101784@hotmail.com;
   cmlin@mail.mcu.edu.tw
OI Lin, Chih-Ming/0000-0001-9637-395X; CHO, TSUNG-HSUN/0000-0003-1421-8943
FU Ministry of Science and Technology [MOST 109-2410-B-130-001]; Ten-Chan
   General Hospital [110001]
FX This research was funded by the Ministry of Science and Technology (MOST
   109-2410-B-130-001) and the Ten-Chan General Hospital (110001).
CR AbdElrahman SM, 2013, J Netw Innov Comput, V2013, P332
   Almeida M, 2007, J BIOL CHEM, V282, P27285, DOI 10.1074/jbc.M702810200
   Bliuc D, 2009, JAMA-J AM MED ASSOC, V301, P513, DOI 10.1001/jama.2009.50
   Breiman L., 2001, Machine Learning, V45, P5, DOI 10.1023/A:1010933404324
   Camelo LV, 2015, SOC SCI MED, V141, P91, DOI 10.1016/j.socscimed.2015.07.032
   Chawla NV, 2002, J ARTIF INTELL RES, V16, P321, DOI 10.1613/jair.953
   Chen FP, 2018, BIOMED J, V41, P202, DOI [10.1016/j.bj.2018.04.001, 10.1016/j.bj.2018.08.001]
   Chen JH, 2017, NEW ENGL J MED, V376, P2507, DOI 10.1056/NEJMp1702071
   Clynes MA, 2020, BRIT MED BULL, V133, P105, DOI 10.1093/bmb/ldaa005
   Cruz AS, 2018, BIOMED ENG ONLINE, V17, DOI 10.1186/s12938-018-0436-1
   Juez FJD, 2011, MATH COMPUT MODEL, V54, P1665, DOI 10.1016/j.mcm.2010.11.069
   Ding C, 2008, J CLIN ENDOCR METAB, V93, P1952, DOI 10.1210/jc.2007-2325
   Friedman J, 2010, J STAT SOFTW, V33, P1, DOI 10.18637/jss.v033.i01
   GREENWOOD D, 1991, BEHAV SCI, V36, P1, DOI 10.1002/bs.3830360102
   Gurka MJ, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-128
   Hoffmann R, 2018, ADV LIFE COURSE RES, V36, P23, DOI 10.1016/j.alcr.2018.02.002
   Hsu WL, 2014, J FORMOS MED ASSOC, V113, P334, DOI 10.1016/j.jfma.2014.02.006
   Huang KC, 2008, OBESITY, V16, P684, DOI 10.1038/oby.2007.112
   Kanis JA, 2007, OSTEOPOROSIS INT, V18, P1033, DOI 10.1007/s00198-007-0343-y
   Kim JY, 2013, KOREAN J FAM MED, V34, P131, DOI 10.4082/kjfm.2013.34.2.131
   Kim J, 2016, PUBLIC HEALTH, V135, P30, DOI 10.1016/j.puhe.2016.01.002
   Liao CM, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15102178
   Lin CM, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17103348
   Liu Q, 2015, BIOMED SIGNAL PROCES, V21, P146, DOI 10.1016/j.bspc.2015.06.002
   Loke SS, 2018, J BONE MINER METAB, V36, P200, DOI 10.1007/s00774-017-0826-7
   Looker AC, 1998, OSTEOPOROSIS INT, V8, P468, DOI 10.1007/s001980050093
   Muka T, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0129116
   Rodríguez AJ, 2017, OSTEOPOROSIS INT, V28, P2239, DOI 10.1007/s00198-017-4024-1
   Shi XP, 2019, ACCIDENT ANAL PREV, V129, P170, DOI 10.1016/j.aap.2019.05.005
   Shioji Mitsunori, 2017, BMC Res Notes, V10, P590, DOI 10.1186/s13104-017-2910-4
   Wong SK, 2016, NUTRIENTS, V8, DOI 10.3390/nu8060347
   Wright NC, 2014, J BONE MINER RES, V29, P2520, DOI 10.1002/jbmr.2269
   Wu Q, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-83828-3
   Yang XH, 2012, INT J PUBLIC HEALTH, V57, P551, DOI 10.1007/s00038-012-0347-z
   Ye CY, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0154740
   Yoo S, 2010, PREV MED, V51, P460, DOI 10.1016/j.ypmed.2010.10.004
   Zhang YY, 2017, INT J RHEUM DIS, V20, P154, DOI 10.1111/1756-185X.12842
   Zhang YH, 2020, ARCH OSTEOPOROS, V15, DOI 10.1007/s11657-020-0691-1
NR 38
TC 3
Z9 3
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD AUG
PY 2021
VL 9
IS 8
AR 948
DI 10.3390/healthcare9080948
PG 15
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA UG3SL
UT WOS:000689176500001
PM 34442085
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Takakura, K
   Oikawa, T
   Nakano, M
   Saeki, C
   Torisu, Y
   Kajihara, M
   Saruta, M
AF Takakura, Kazuki
   Oikawa, Tsunekazu
   Nakano, Masanori
   Saeki, Chisato
   Torisu, Yuichi
   Kajihara, Mikio
   Saruta, Masayuki
TI Recent Insights Into the Multiple Pathways Driving Non-alcoholic
   Steatohepatitis-Derived Hepatocellular Carcinoma
SO FRONTIERS IN ONCOLOGY
LA English
DT Review
DE hepatocellular carcinoma; non-alcoholic steatohepatitis; non-alcoholic
   fatty liver disease; tumor necrosis factor; dysbiosis; signal transducer
   and activator of transcription
ID FATTY LIVER-DISEASE; INTESTINAL BACTERIAL OVERGROWTH;
   NECROSIS-FACTOR-ALPHA; ER STRESS; METABOLIC SYNDROME; OBESITY;
   AUTOPHAGY; CANCER; NASH; PROGRESSION
AB The incidence of metabolic syndrome with fatty liver is spreading on a worldwide scale. Correspondingly, the number of patients with the hepatic phenotype of metabolic syndrome, non-alcoholic fatty liver disease (NAFLD), and in its advanced states, non-alcoholic steatohepatitis (NASH), and the subsequent hepatocellular carcinoma (HCC) derived from NASH (NASH-HCC) is increasing remarkably. A large-scale epidemiological study revealed that obesity can be a risk factor of such cancers as HCC. Moreover, despite the ongoing trends of declining cancer incidence and mortality for most cancer types, HCC has experienced a markedly increased rate of both. Considering the differences in liver-related mortality among NAFLD patients, NASH, and NASH-HCC should be included in the objectives of initiatives to manage NAFLD patients and their progression to the advanced stages. Unfortunately, research has yet to make a crucial drug discovery for the effective treatment of NASH and NASH-HCC, although it is urgently needed. The latest widespread concept of the "multiple parallel hits hypothesis," whereby multiple factors contribute concurrently to disease pathogenesis has led to advances in the elucidation of hepatic and systemic molecular mechanisms driving NASH and the subsequent NASH-HCC progression; the results are not only extensive but promising for therapeutics. Here, we have summarized the myriad landmark discoveries of recent research into the pathogenic processes underlying NASH-HCC development and with the greatest possibility for a new generation of pharmaceutical products for interference and treatment.
C1 [Takakura, Kazuki; Oikawa, Tsunekazu; Nakano, Masanori; Saeki, Chisato; Torisu, Yuichi; Kajihara, Mikio; Saruta, Masayuki] Jikei Univ, Sch Med, Div Gastroenterol & Hepatol, Dept Internal Med, Tokyo, Japan.
C3 Jikei University
RP Takakura, K (corresponding author), Jikei Univ, Sch Med, Div Gastroenterol & Hepatol, Dept Internal Med, Tokyo, Japan.
EM ktakakura@jikei.ac.jp
RI Saruta, Masayuki/ABL-4991-2022
OI TORISU, YUICHI/0000-0002-2349-8855; Saruta, Masayuki/0000-0001-8172-3240
CR Alexander J, 2013, J GASTROEN HEPATOL, V28, P848, DOI 10.1111/jgh.12116
   Anstee QM, 2019, NAT REV GASTRO HEPAT, V16, P411, DOI 10.1038/s41575-019-0145-7
   Baffy G, 2012, J HEPATOL, V56, P1384, DOI 10.1016/j.jhep.2011.10.027
   Bhaskaran K, 2014, LANCET, V384, P755, DOI 10.1016/S0140-6736(14)60892-8
   Calvisi DF, 2006, GASTROENTEROLOGY, V130, P1117, DOI 10.1053/j.gastro.2006.01.006
   Cuervo AM, 2005, AUTOPHAGY, V1, P131, DOI 10.4161/auto.1.3.2017
   Czaja MJ, 2013, AUTOPHAGY, V9, P1131, DOI 10.4161/auto.25063
   Dapito DH, 2012, CANCER CELL, V21, P504, DOI 10.1016/j.ccr.2012.02.007
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   DeMinicis S, 2014, HEPATOLOGY, V59, P1738, DOI 10.1002/hep.26695
   Dreval K, 2019, FRONT GENET, V10, DOI 10.3389/fgene.2019.00486
   Elinav E, 2011, CELL, V145, P745, DOI 10.1016/j.cell.2011.04.022
   Farrell GC, 2012, GUT LIVER, V6, P149, DOI 10.5009/gnl.2012.6.2.149
   Font-Burgada J, 2016, CELL METAB, V23, P48, DOI 10.1016/j.cmet.2015.12.015
   González-Rodríguez A, 2014, CELL DEATH DIS, V5, DOI 10.1038/cddis.2014.162
   Grohmann M, 2018, CELL, V175, P1289, DOI 10.1016/j.cell.2018.09.053
   Harte AL, 2010, J INFLAMM-LOND, V7, DOI 10.1186/1476-9255-7-15
   He GB, 2013, CELL, V155, P384, DOI 10.1016/j.cell.2013.09.031
   He GB, 2010, CANCER CELL, V17, P286, DOI 10.1016/j.ccr.2009.12.048
   Henao-Mejia J, 2012, NATURE, V482, P179, DOI 10.1038/nature10809
   Hildebrandt MA, 2009, GASTROENTEROLOGY, V137, P1716, DOI 10.1053/j.gastro.2009.08.042
   Kawaguchi T, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038322
   Kutlu O, 2018, CAN J GASTROENTEROL, V2018, DOI 10.1155/2018/8543763
   Lazo M, 2013, AM J EPIDEMIOL, V178, P38, DOI 10.1093/aje/kws448
   Li ST, 2017, HEPATOLOGY, V66, P936, DOI 10.1002/hep.29229
   Liu HY, 2009, J BIOL CHEM, V284, P31484, DOI 10.1074/jbc.M109.033936
   Malhi H, 2011, J HEPATOL, V54, P795, DOI 10.1016/j.jhep.2010.11.005
   Mathew R, 2009, CELL, V137, P1062, DOI 10.1016/j.cell.2009.03.048
   Miele L, 2009, HEPATOLOGY, V49, P1877, DOI 10.1002/hep.22848
   Mittal S, 2015, CLIN GASTROENTEROL H, V13, P594, DOI 10.1016/j.cgh.2014.08.013
   Nakagawa H, 2014, CANCER CELL, V26, P331, DOI 10.1016/j.ccr.2014.07.001
   Naugler WE, 2007, SCIENCE, V317, P121, DOI 10.1126/science.1140485
   Okada H, 2017, ONCOTARGET, V8, P39978, DOI 10.18632/oncotarget.18116
   Ota T, 2008, J CLIN INVEST, V118, P316, DOI 10.1172/JCI32752
   Paradis V, 2009, HEPATOLOGY, V49, P851, DOI 10.1002/hep.22734
   Park EJ, 2010, CELL, V140, P197, DOI 10.1016/j.cell.2009.12.052
   Qiu W, 2011, HEPATOLOGY, V53, P1515, DOI 10.1002/hep.24269
   Rahman R, 2013, WORLD J GASTRO ONCOL, V5, P186, DOI 10.4251/wjgo.v5.i9.186
   Raman M, 2013, CLIN GASTROENTEROL H, V11, P868, DOI 10.1016/j.cgh.2013.02.015
   Ringelhan M, 2018, NAT IMMUNOL, V19, P222, DOI 10.1038/s41590-018-0044-z
   Rivera CA, 2007, J HEPATOL, V47, P571, DOI 10.1016/j.jhep.2007.04.019
   Romeo S, 2008, NAT GENET, V40, P1461, DOI 10.1038/ng.257
   Rutkowski DT, 2008, DEV CELL, V15, P829, DOI 10.1016/j.devcel.2008.10.015
   Ryerson AB, 2016, CANCER-AM CANCER SOC, V122, P1312, DOI 10.1002/cncr.29936
   Sabaté JM, 2008, OBES SURG, V18, P371, DOI 10.1007/s11695-007-9398-2
   Schulze K, 2015, NAT GENET, V47, P505, DOI 10.1038/ng.3252
   Seki E, 2007, NAT MED, V13, P1324, DOI 10.1038/nm1663
   Takuma Y, 2010, WORLD J GASTROENTERO, V16, P1436, DOI 10.3748/wjg.v16.i12.1436
   Tanaka S, 2016, HEPATOLOGY, V64, P1994, DOI 10.1002/hep.28820
   Tilg H, 2010, HEPATOLOGY, V52, P1836, DOI 10.1002/hep.24001
   Tomita K, 2006, GUT, V55, P415, DOI 10.1136/gut.2005.071118
   Ueyama M, 2016, J GASTROENTEROL, V51, P370, DOI 10.1007/s00535-015-1116-6
   Wigg AJ, 2001, GUT, V48, P206, DOI 10.1136/gut.48.2.206
   Yang L, 2010, CELL METAB, V11, P467, DOI 10.1016/j.cmet.2010.04.005
   Yoo C, 2019, CANCER RES TREAT, V51, P510, DOI 10.4143/crt.2018.226
   Yoshimoto S, 2013, NATURE, V499, P97, DOI 10.1038/nature12347
   Younes R, 2018, J HEPATOL, V68, P326, DOI 10.1016/j.jhep.2017.10.006
   Younossi ZM, 2019, J HEPATOL, V70, P531, DOI 10.1016/j.jhep.2018.10.033
   Zhu LX, 2013, HEPATOLOGY, V57, P601, DOI 10.1002/hep.26093
NR 59
TC 29
Z9 29
U1 0
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD AUG 13
PY 2019
VL 9
AR 762
DI 10.3389/fonc.2019.00762
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA IQ1RL
UT WOS:000480527900002
PM 31456946
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kagota, S
   Iwata, S
   Maruyama, K
   McGuire, JJ
   Shinozuka, K
AF Kagota, Satomi
   Iwata, Saki
   Maruyama, Kana
   McGuire, John J.
   Shinozuka, Kazumasa
TI Time-Dependent Differences in the Influence of Perivascular Adipose
   Tissue on Vasomotor Functions in Metabolic Syndrome
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE mesenteric artery; metabolic syndrome; nitric oxide; perivascular
   adipose tissue; vasodilation
ID VASCULAR FUNCTION; ANIMAL-MODEL; RATS; FAT; DYSFUNCTION; DISEASE;
   STRESS; VASODILATION; INFLAMMATION; ENDOTHELIUM
AB Background: Metabolic syndrome (MetS) facilitates the development of cardiovascular disease due to atherosclerosis, which is accelerated by defects of the vascular endothelium. Vascular dysfunction in response to nitric oxide (NO) occurs in the mesenteric arteries of an animal model of MetS, SHRSP. Z-Lepr fa /IzmDmcr (SHRSP. ZF) rats. Vascular responses to vasodilators are affected by perivascular adipose tissue (PVAT) that surrounds the outsides of arteries. In this study, we assessed the role of PVAT in vascular dysfunction observed in SHRSP. ZF.
   Methods: To determine the effects of PVAT on vasodilators in SHRSP. ZF and control Wistar-Kyoto (WKY) rats, we used organ bath bioassay techniques to assay acetylcholine and nitroprusside-induced relaxations of isolated mesenteric arterial ring preparations with PVAT intact or removed.
   Results: A PVAT-mediated enhancement of relaxations induced by acetylcholine and nitroprusside occurred in SHRSP. ZF at 20 weeks of age, but not at 10 and 30 weeks, and did not occur in WKY. Furthermore, the enhancing effects of PVAT from SHRSP. ZF at 20 weeks could not be substituted by replacement with PVAT from either WKY or 30-week-old SHRSP. ZF, was inhibited by NO synthase inhibitor, and abolished by removal of the arteries' endothelium. Cyclic guanosine monophosphate (cGMP) accumulation elicited by nitroprusside was higher in SHRSP. ZF arteries with PVAT than arteries without PVAT at 20 weeks, but the enhancement of cGMP accumulation did not occur at 30 weeks.
   Conclusions: PVAT may regulate arterial tone by releasing diffusible vasorelaxing factor(s), which, through endothelium-derived NO production, compensates for impaired vasodilations at early stages of MetS.
C1 [Kagota, Satomi; Iwata, Saki; Maruyama, Kana; Shinozuka, Kazumasa] Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Nishinomiya, Hyogo, Japan.
   [McGuire, John J.] Mem Univ, Div Biomed Sci, Fac Med, St John, NF, Canada.
C3 Mukogawa Women's University; Memorial University Newfoundland
RP Kagota, S (corresponding author), 11-68 Koshien Kyuban Cho, Nishinomiya, Hyogo 6638179, Japan.
EM skagota@mukogawa-u.ac.jp
OI McGuire, John/0000-0003-0302-3884
FU MEXT KAKENHI [16K08563]; Grants-in-Aid for Scientific Research
   [16K08563] Funding Source: KAKEN
FX This work was partly supported by MEXT KAKENHI (grant number 16K08563 to
   S.K.).
CR Almabrouk TAM, 2014, BRIT J PHARMACOL, V171, P595, DOI 10.1111/bph.12479
   Brown NK, 2014, ARTERIOSCL THROM VAS, V34, P1621, DOI 10.1161/ATVBAHA.114.303029
   Contreras GA, 2016, PHYSIOL REP, V4, DOI 10.14814/phy2.12993
   Farias-Itao DS, 2016, JMIR RES PROTOC, V5, DOI 10.2196/resprot.6340
   Fésüs G, 2007, CARDIOVASC RES, V75, P719, DOI 10.1016/j.cardiores.2007.05.025
   Fitzgibbons TP, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.113.000582
   Gao YJ, 2007, BRIT J PHARMACOL, V151, P323, DOI 10.1038/sj.bjp.0707228
   Gil-Ortega M, 2015, TRENDS ENDOCRIN MET, V26, P367, DOI 10.1016/j.tem.2015.04.003
   Gil-Ortega M, 2010, ENDOCRINOLOGY, V151, P3299, DOI 10.1210/en.2009-1464
   Hiraoka-Yamamoto J, 2004, CLIN EXP PHARMACOL P, V31, P107, DOI 10.1111/j.1440-1681.2004.04121.x
   Kagota S, 2006, LIFE SCI, V78, P1187, DOI 10.1016/j.lfs.2005.06.029
   Kagota S, 2013, MICROVASC RES, V88, P70, DOI 10.1016/j.mvr.2013.04.001
   Kagota S, 2010, CLIN EXP PHARMACOL P, V37, P1035, DOI 10.1111/j.1440-1681.2010.05432.x
   Ketonen J, 2010, CIRC J, V74, P1479, DOI 10.1253/circj.CJ-09-0661
   Kubota Y, 2006, BIOL PHARM BULL, V29, P1756, DOI 10.1248/bpb.29.1756
   Lee RMKW, 2009, CAN J PHYSIOL PHARM, V87, P944, DOI [10.1139/Y09-088, 10.1139/y09-088]
   Lee RMKW, 2009, J HYPERTENS, V27, P782, DOI 10.1097/HJH.0b013e328324ed86
   Lehman SJ, 2010, ATHEROSCLEROSIS, V210, P656, DOI 10.1016/j.atherosclerosis.2010.01.007
   Lian XM, 2016, CURR HYPERTENS REP, V18, DOI 10.1007/s11906-016-0692-z
   Löhn M, 2002, FASEB J, V16, P1057, DOI 10.1096/fj.02-0024com
   Maenhaut N, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-25
   Maruyama K, 2016, CAN J PHYSL PHARM, V19, P1
   Mendizábal Y, 2013, LIFE SCI, V93, P1023, DOI 10.1016/j.lfs.2013.10.021
   Mendizábal Y, 2013, INT J HYPERTENS, V2013, DOI 10.1155/2013/230868
   Ohyama K, 2016, CIRC J, V80, P1653, DOI 10.1253/circj.CJ-16-0213
   Oowatari Y, 2016, BIOSCI BIOTECH BIOCH, V80, P1594, DOI 10.1080/09168451.2016.1179093
   Owen MK, 2013, CIRCULATION, V128, P9, DOI 10.1161/CIRCULATIONAHA.112.001238
   Ozen G, 2015, EUR J PHARMACOL, V766, P16, DOI 10.1016/j.ejphar.2015.09.012
   Sacks HS, 2013, J CLIN ENDOCR METAB, V98, pE1448, DOI 10.1210/jc.2013-1265
   SOLTIS EE, 1991, CLIN EXP HYPERTENS A, V13, P277, DOI 10.3109/10641969109042063
   Spradley FT, 2016, AM J PHYSIOL-REG I, V310, pR286, DOI 10.1152/ajpregu.00469.2014
   Sugiyama F, 2013, CLIN EXP NEPHROL, V17, P515, DOI 10.1007/s10157-012-0759-3
   Szasz T, 2013, VASC HEALTH RISK MAN, V9, P105, DOI 10.2147/VHRM.S33760
   Tada Y, 2010, BIOL PHARM BULL, V33, P1971, DOI 10.1248/bpb.33.1971
   Verhagen SN, 2011, ATHEROSCLEROSIS, V214, P3, DOI 10.1016/j.atherosclerosis.2010.05.034
   Wu T, 2016, CLIN EXP PHARMACOL P, V43, P459, DOI 10.1111/1440-1681.12547
   Xia N, 2016, ARTERIOSCL THROM VAS, V36, P78, DOI 10.1161/ATVBAHA.115.306263
NR 37
TC 8
Z9 8
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD JUN
PY 2017
VL 15
IS 5
BP 233
EP 239
DI 10.1089/met.2016.0146
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA EV4JS
UT WOS:000401726400005
PM 28358621
DA 2025-06-11
ER

PT J
AU Lagos, KG
   Filippatos, TD
   Tsimihodimos, V
   Gazi, IF
   Rizos, C
   Tselepis, AD
   Mikhailidis, DP
   Elisaf, MS
AF Lagos, K. G.
   Filippatos, T. D.
   Tsimihodimos, V.
   Gazi, I. F.
   Rizos, C.
   Tselepis, A. D.
   Mikhailidis, D. P.
   Elisaf, Moses S.
TI Alterations in the High Density Lipoprotein Phenotype and HDL-Associated
   Enzymes in Subjects with Metabolic Syndrome
SO LIPIDS
LA English
DT Article
DE Metabolic syndrome; High density lipoprotein; Subclasses; Lipoprotein
   associated phospholipase A(2); Paraoxonase 1; High sensitivity
   C-reactive protein; Small dense low density lipoprotein cholesterol;
   Triglycerides
ID ELEVATED OXIDATIVE STRESS; ACETYLHYDROLASE ACTIVITY; CARDIOVASCULAR
   EVENTS; PARAOXONASE ACTIVITY; CLINICAL IMPORTANCE; PHOSPHOLIPASE A(2);
   OBESE-PATIENTS; CHOLESTEROL; PARTICLES; LDL
AB Patients with metabolic syndrome (MetS) usually have low high density lipoprotein cholesterol (HDL-C) levels. We determined the HDL distribution profile as well as the HDL-related lipoprotein associated phospholipase A(2) (HDL-LpPLA(2)) and paraoxonase-1 (PON1) activities in subjects with MetS (n = 189) but otherwise healthy. Age and sex-matched individuals (n = 166) without MetS served as controls. The lower HDL-C concentration in MetS patients was due to a reduction in both large and small HDL subclasses (P < 0.001 and P < 0.05, respectively). As the number of MetS components increased, the HDL phenotype comprised of a greater percentage of small HDL-3 and less large HDL-2 subclasses, resulting in a decreased HDL-2/HDL-3 ratio (P < 0.001 for all trends). Multivariate analysis revealed that HDL-2 levels and the HDL-2/HDL-3 ratio significantly and independently correlated with HDL-C (positively) and TG (negatively) levels. HDL-3 concentration significantly and independently positively correlated with HDL-C and TG levels. HDL-LpPLA(2) activity was decreased in MetS patients (P < 0.01), a phenomenon that may contribute to the defective antiatherogenic activity of HDL in MetS. PON1 activity did not differ between groups. We conclude that MetS, in addition to the decrease in HDL-C concentration, is associated with alterations in the HDL phenotype, which is comprised of a greater percentage of small HDL subclasses. Furthermore, HDL-LpPLA(2) activity is decreased in MetS patients.
C1 [Lagos, K. G.; Tsimihodimos, V.; Gazi, I. F.; Rizos, C.; Elisaf, Moses S.] Univ Ioannina, Sch Med, Dept Internal Med, GR-45110 Ioannina, Greece.
   [Filippatos, T. D.; Mikhailidis, D. P.] UCL, Dept Clin Biochem, London, England.
   [Tselepis, A. D.] Univ Ioannina, Dept Chem, Biochem Lab, Ioannina, Greece.
C3 University of Ioannina; University of London; University College London;
   University of Ioannina
RP Elisaf, MS (corresponding author), Univ Ioannina, Sch Med, Dept Internal Med, GR-45110 Ioannina, Greece.
EM egepi@cc.uoi.gr
RI Tsimihodimos, Vasilis/AAN-9888-2021; Rizos, Christos/AAQ-5981-2020;
   Mikhailidis, Dimitri/A-1869-2013; Filippatos, Theodosios/I-6016-2016
OI ELISAF, MOSES/0000-0003-0505-078X; Tsimihodimos,
   Vasilis/0000-0003-1708-3415; Filippatos, Theodosios/0000-0002-1713-0923;
   Rizos, Christos/0000-0003-3495-9175
CR Asztalos BF, 2004, ARTERIOSCL THROM VAS, V24, P2181, DOI 10.1161/01.ATV.0000146325.93749.a8
   Asztalos BF, 2005, ARTERIOSCL THROM VAS, V25, P2185, DOI 10.1161/01.ATV.0000183727.90611.4f
   Asztalos BF, 2003, ARTERIOSCL THROM VAS, V23, P847, DOI 10.1161/01.ATV.0000066133.32063.BB
   Athyros VG, 2008, ATHEROSCLEROSIS, V200, P1, DOI 10.1016/j.atherosclerosis.2008.02.026
   Bairaktari ET, 2005, J CARDIOVASC PHARM T, V10, P45, DOI 10.1177/107424840501000106
   Brites FD, 2004, ARCH MED RES, V35, P235, DOI 10.1016/j.arcmed.2004.02.002
   Chapman MJ, 2004, CURR MED RES OPIN, V20, P1253, DOI 10.1185/030079904125004402
   Daskalopoulou SS, 2004, ANGIOLOGY, V55, P589, DOI 10.1177/00033197040550i601
   de Souza JA, 2008, ATHEROSCLEROSIS, V197, P84, DOI 10.1016/j.atherosclerosis.2007.08.009
   Deeb SS, 2003, J LIPID RES, V44, P1279, DOI 10.1194/jlr.R200017-JLR200
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Eisaf M, 2003, BIOCHEM PHARMACOL, V66, P2069, DOI 10.1016/S0006-2952(03)00559-8
   Filippatos TD, 2008, DIABETES OBES METAB, V10, P476, DOI 10.1111/j.1463-1326.2007.00733.x
   Filippatos TD, 2007, ATHEROSCLEROSIS, V193, P428, DOI 10.1016/j.atherosclerosis.2006.07.010
   Filippatos TD, 2008, ARCH MED SCI, V4, P263
   Florentin M, 2008, CURR OPIN CARDIOL, V23, P370, DOI 10.1097/HCO.0b013e3283043806
   Garin MCB, 2005, J CLIN ENDOCR METAB, V90, P2264, DOI 10.1210/jc.2004-1295
   Gazi I, 2005, CLIN CHEM, V51, P2264, DOI 10.1373/clinchem.2005.058404
   Gazi I, 2006, METABOLISM, V55, P885, DOI 10.1016/j.metabol.2006.02.015
   Gazi IF, 2007, EXPERT OPIN BIOL TH, V7, P53, DOI 10.1517/14712598.7.1.53
   Grundy Scott M, 2004, J Am Coll Cardiol, V44, P720, DOI 10.1016/j.jacc.2004.07.001
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Hansel Boris, 2006, Curr Atheroscler Rep, V8, P501, DOI 10.1007/s11883-006-0026-8
   Hedrick CC, 2000, DIABETOLOGIA, V43, P312, DOI 10.1007/s001250050049
   James RW, 2006, CLIN CHEM LAB MED, V44, P1052, DOI 10.1515/CCLM.2006.207
   Ji JY, 2006, J CLIN ENDOCR METAB, V91, P973, DOI 10.1210/jc.2005-1895
   Kalmár T, 2005, DIABETES METAB, V31, P574, DOI 10.1016/S1262-3636(07)70233-1
   Kathiresan S, 2006, CIRCULATION, V113, P20, DOI 10.1161/CIRCULATIONAHA.105.567107
   Kontush A, 2006, NAT CLIN PRACT CARD, V3, P144, DOI 10.1038/ncpcardio0500
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Link JJ, 2007, CURR PROB CARDIOLOGY, V32, P268, DOI 10.1016/j.cpcardiol.2007.01.004
   Mackness B, 2000, CLIN SCI, V98, P355, DOI 10.1042/CS19990239
   MACKNESS MI, 1991, ATHEROSCLEROSIS, V86, P193, DOI 10.1016/0021-9150(91)90215-O
   Mackness MI, 1996, CURR OPIN LIPIDOL, V7, P69, DOI 10.1097/00041433-199604000-00004
   MACKNESS MI, 1995, ATHEROSCLEROSIS, V115, P243, DOI 10.1016/0021-9150(94)05524-M
   Mackness MI, 2002, ATHEROSCLEROSIS SUPP, V3, P49, DOI 10.1016/S1567-5688(02)00046-6
   MACKNESS MI, 1993, ATHEROSCLEROSIS, V104, P129, DOI 10.1016/0021-9150(93)90183-U
   Milionis HJ, 2005, STROKE, V36, P1372, DOI 10.1161/01.STR.0000169935.35394.38
   Moldoveanu E, 2006, EUR J INTERN MED, V17, P38, DOI 10.1016/j.ejim.2005.09.015
   Nobécourt E, 2005, DIABETOLOGIA, V48, P529, DOI 10.1007/s00125-004-1655-5
   Otvos JD, 2006, CIRCULATION, V113, P1556, DOI 10.1161/CIRCULATIONAHA.105.565135
   Persson M, 2007, ARTERIOSCL THROM VAS, V27, P1411, DOI 10.1161/ATVBAHA.107.142679
   Rizos E, 2005, PROSTAG LEUKOTR ESS, V72, P203, DOI 10.1016/j.plefa.2004.10.021
   Rysz J, 2007, ARCH IMMUNOL THER EX, V55, P335, DOI 10.1007/s00005-007-0033-7
   SALONEN JT, 1991, CIRCULATION, V84, P129, DOI 10.1161/01.CIR.84.1.129
   Saltevo J, 2007, MEDIAT INFLAMM, V2007, DOI 10.1155/2007/93573
   Saougos VG, 2007, ARTERIOSCL THROM VAS, V27, P2236, DOI 10.1161/ATVBAHA.107.147280
   Tselepis AD, 2002, ATHEROSCLEROSIS SUPP, V3, P57, DOI 10.1016/S1567-5688(02)00045-4
   TSELEPIS AD, 1995, ARTERIOSCL THROM VAS, V15, P1764, DOI 10.1161/01.ATV.15.10.1764
   Tsimihodimos V, 2002, ARTERIOSCL THROM VAS, V22, P306, DOI 10.1161/hq0202.102918
   von Eckardstein A, 2001, ARTERIOSCL THROM VAS, V21, P13, DOI 10.1161/01.ATV.21.1.13
NR 51
TC 64
Z9 66
U1 1
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0024-4201
EI 1558-9307
J9 LIPIDS
JI Lipids
PD JAN
PY 2009
VL 44
IS 1
BP 9
EP 16
DI 10.1007/s11745-008-3251-9
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 385CN
UT WOS:000261790800002
PM 18956219
DA 2025-06-11
ER

PT J
AU Icagasioglu, A
   Turgut, ST
   Atlig, RS
   Senturk, S
   Oguz, A
   Mesci, E
AF Icagasioglu, Afitap
   Turgut, Selin Turan
   Atlig, Raife Sirin
   Senturk, Senem
   Oguz, Aytekin
   Mesci, Erkan
TI IMPACTS OF OBESITY ON PAIN THRESHOLD, DEPRESSION AND QUALITY OF LIFE
SO ACTA MEDICA MEDITERRANEA
LA English
DT Article
DE Obesity; pain threshold; quality of life; depression
ID BODY-MASS INDEX; OLDER MEN; SENSITIVITY; WOMEN; RATS; POPULATION;
   ULTRASOUND; LEPTIN
AB Introduction: Obesity can effect pain threshold, emotional mood and quality of life. Differences in pain thresholds and emotional mood may have implications for pain and depression management. The aim of this study was to assess the effects of obesity on pain threshold, depression and quality of life.
   Materials and methods: This study was designed as a cross-sectional observational study and carried out on 80 adult obese and nonobese people aged between 18 and 40 years who were admitted to the obesity and metabolic syndrome outpatient clinics. The subcutaneous adipose tissue thickness was measured for rectus femoris, triceps muscle, and umbilicus by using ultrasonography. The pressure pain thresholds in 3 muscles including the deltoid, tibialis anterior, and first interosseus dorsalis muscle of the hand were measured by using a digital pressure algometer. The subjects were evaluated by visual analogue scale (VAS) when a pressure was applied on the first distal phalanx (FDP) at a rate of 25 Newton. Depression levels of the subjects were evaluated by the Beck Depression Inventory (BDI). Quality of life was evaluated by Short Form 36 (SF-36).
   Results: The mean pain threshold values showed no statistically significant difference between groups (p>0.05). The mean values of adipose thickness were significantly higher in the obese group (p<0.01). No statistically significant difference was determined between the groups in terms of FDP VAS scores (p>0.05). The obese group had significantly higher BDI scores than the control group(p<0.01). All parameters of SF-36 were significantly lower in obese individuals(p<0.01).
   Conclusions: Our findings suggest no significant correlation between obesity and pain threshold. But we found strong relationship between obesity and both for depression and quality of life
C1 [Icagasioglu, Afitap; Mesci, Erkan] Medeniyet Univ, Goztepe Training & Res Hosp, Dept Phys Med & Rehabil, Istanbul, Turkey.
   [Turgut, Selin Turan] Karaman State Hosp, Dept Phys Med & Rehabil, Karaman, Turkey.
   [Atlig, Raife Sirin] Avicenna Umut Hosp, Dept Phys Med & Rehabil, Istanbul, Turkey.
   [Senturk, Senem] Istanbul Medeniyet Univ, Goztepe Training & Res Hosp, Dept Radiol, Istanbul, Turkey.
   [Oguz, Aytekin] Medeniyet Univ, Goztepe Training & Res Hosp, Dept Internal Med, Istanbul, Turkey.
C3 Istanbul Medeniyet University; Istanbul Goztepe Training & Research
   Hospital; Karaman State Hospital; Avicenna Hospital; Istanbul Medeniyet
   University; Istanbul Goztepe Training & Research Hospital; Istanbul
   Goztepe Training & Research Hospital; Istanbul Medeniyet University
RP Icagasioglu, A (corresponding author), Istanbul Medeniyet Univ, Goztepe Training & Res Hosp, Dept Phys Med & Rehabil, Fahrettin Kerim Gokay Cad Kadikoy, Istanbul, Turkey.
RI Oguz, Aytekin/AAJ-2732-2021
CR Bray GA, 2003, ENDOCRIN METAB CLIN, V32, P787, DOI 10.1016/S0889-8529(03)00067-7
   Broberger C, 2005, J INTERN MED, V258, P301, DOI 10.1111/j.1365-2796.2005.01553.x
   Cowley MA, 2003, NEURON, V37, P649, DOI 10.1016/S0896-6273(03)00063-1
   Dinç G, 2006, ASIA PAC J CLIN NUTR, V15, P508
   Dodet P, 2013, CLIN J PAIN, V29, P43, DOI 10.1097/AJP.0b013e31824786ad
   Doll HA, 2000, OBES RES, V8, P160, DOI 10.1038/oby.2000.17
   Elovainio M, 2009, PSYCHOSOM MED, V71, P423, DOI 10.1097/PSY.0b013e31819e333a
   Ensari G, 2010, MED HYPOTHESES, V74, P452
   Fillingim Roger B, 2005, Curr Rheumatol Rep, V7, P342, DOI 10.1007/s11926-005-0018-7
   Iannone F, 2010, CURR DRUG TARGETS, V11, P586, DOI 10.2174/138945010791011857
   Khimich S, 1997, Acta Chir Hung, V36, P166
   Kim CH, 2012, ARTHRIT CARE RES, V64, P222, DOI 10.1002/acr.20653
   Kinser AM, 2009, J STRENGTH COND RES, V23, P312, DOI 10.1519/JSC.0b013e31818f051c
   Kolotkin R L, 2001, Obes Rev, V2, P219, DOI 10.1046/j.1467-789X.2001.00040.x
   Kutlu S, 2003, NEUROENDOCRINOL LETT, V24, P193
   Linares CL, 2009, CLIN PHARMACOKINET, V48, P635, DOI 10.2165/11317150-000000000-00000
   Maffiuletti NA, 2011, MUSCLE NERVE, V44, P202, DOI 10.1002/mus.22050
   MCKENDALL MJ, 1983, PSYCHIAT RES, V8, P119, DOI 10.1016/0165-1781(83)90099-9
   Milaneschi Y, 2012, J CLIN PSYCHIAT, V73, P1205, DOI 10.4088/JCP.11m07552
   Miscio G, 2005, J PERIPHER NERV SYST, V10, P354, DOI 10.1111/j.1085-9489.2005.00047.x
   Nordander C, 2003, EUR J APPL PHYSIOL, V89, P514, DOI 10.1007/s00421-003-0819-1
   PRADALIER A, 1980, PATHOL BIOL, V28, P462
   RAMZAN I, 1993, PHYSIOL BEHAV, V54, P433, DOI 10.1016/0031-9384(93)90231-4
   RAYMOND NC, 1995, BIOL PSYCHIAT, V37, P202, DOI 10.1016/0006-3223(94)00244-W
   ROANE DS, 1986, PHYSIOL BEHAV, V38, P215, DOI 10.1016/0031-9384(86)90156-3
   Rolfe ED, 2010, OBESITY, V18, P625, DOI 10.1038/oby.2009.309
   Turk DC., 1992, HDB PAIN ASSESSMENT, P3
   Turk DC, 1984, INT J PSYCHIAT MED, V13, P57
   ZAHORSKA-MARKIEWICZ B, 1988, Acta Physiologica Polonica, V39, P183
   ZAHORSKAMARKIEWICZ B, 1983, HUM NUTR-CLIN NUTR, V37, P307
NR 30
TC 2
Z9 2
U1 0
U2 15
PU CARBONE EDITORE
PI PALERMO
PA VIA QUINTINO SELLA, 68, PALERMO, 90139, ITALY
SN 0393-6384
EI 2283-9720
J9 ACTA MEDICA MEDITERR
JI Acta Medica Mediterr.
PY 2015
VL 31
IS 1
BP 43
EP 48
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AW5MM
UT WOS:000346319200006
DA 2025-06-11
ER

PT J
AU Seidita, A
   Soresi, M
   Giannitrapani, L
   Di Stefano, V
   Citarrella, R
   Mirarchi, L
   Cusimano, A
   Augello, G
   Carroccio, A
   Iovanna, JL
   Cervello, M
AF Seidita, Aurelio
   Soresi, Maurizio
   Giannitrapani, Lydia
   Di Stefano, Vita
   Citarrella, Roberto
   Mirarchi, Luigi
   Cusimano, Antonella
   Augello, Giuseppa
   Carroccio, Antonio
   Iovanna, Juan Lucio
   Cervello, Melchiorre
TI The clinical impact of an extra virgin olive oil enriched mediterranean
   diet on metabolic syndrome: Lights and shadows of a nutraceutical
   approach
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE extra virgin olive oil (EVOO); nutraceuticals; functional foods;
   metabolic syndrome; cardiovascular disease; insulin resistance
ID NONALCOHOLIC FATTY LIVER; ENDOTHELIAL FUNCTION; PHENOLIC-COMPOUNDS;
   HEPATIC STEATOSIS; OXIDATIVE STRESS; HEALTHY-SUBJECTS; LIPID PROFILE;
   STYLE DIET; FACTOR-VII; POLYPHENOLS
AB For years it has been established that the only truly effective treatment of metabolic syndrome (MS) is lifestyle modification to prevent its cardiovascular (e.g., coronary artery disease and atherosclerosis), metabolic (e.g., diabetes mellitus), and hepatic (e.g., steatosis and non-alcoholic steatohepatitis) complications. The focal points of this approach are to increase physical activity and intake of a diet characterized by high quantities of fruits, vegetables, grains, fish, and low-fat dairy products, the so called mediterranean diet (MD); however, the added value of MD is the presence of extra virgin olive oil (EVOO), a healthy food with a high content of monounsaturated fatty acids, especially oleic acid, and variable concentrations (range 50-800 mg/kg) of phenols (oleuropein, ligstroside, and oleocanthal, and their derivatives, phenolic alcohols, such as hydroxytyrosol and tyrosol). Phenolic compounds not only determine EVOO's main organoleptic qualities (oxidative stability, specific flavor, and taste features) but, theoretically, make it a source of antioxidant, anti-inflammatory, insulin-sensitizing, cardioprotective, antiatherogenic, neuroprotective, immunomodulatory, and anticancer activity. Although many studies have been carried out on EVOO's clinical effects and attention toward this dietary approach (healthy and palatable food with strong nutraceutical activity) has become increasingly pressing, there are still many dark sides to be clarified, both in terms of actual clinical efficacy and biochemical and molecular activity. Thus, we reviewed the international literature, trying to show the state of the art about EVOO's clinical properties to treat MS (along with correlated complications) and the future prospective of its nutraceutical use.
C1 [Seidita, Aurelio; Soresi, Maurizio; Giannitrapani, Lydia; Citarrella, Roberto; Mirarchi, Luigi] Univ Palermo, Dept Hlth Promot Sci Maternal & Infant Care Inter, Unit Internal Med, Palermo, Italy.
   [Giannitrapani, Lydia; Cusimano, Antonella; Augello, Giuseppa; Cervello, Melchiorre] CNR, Inst Biomed Res & Innovat IRIB, Palermo, Italy.
   [Di Stefano, Vita] Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol STEBICE, Palermo, Italy.
   [Carroccio, Antonio] Osped Riuniti Villa Sofia Cervello, Unit Internal Med, V Cervello Hosp, Palermo, Italy.
   [Carroccio, Antonio] Univ Palermo, Dept Hlth Promot Sci Maternal & Infant Care Inter, Palermo, Italy.
   [Iovanna, Juan Lucio] Aix Marseille Univ, CNRS, Inst Paoli Calmettes, Canc Res Ctr Marseille,INSERM,CRCM, Marseille, France.
C3 University of Palermo; Consiglio Nazionale delle Ricerche (CNR);
   Istituto Ricerca l'Innovazione Biomedica (IRIB-CNR); University of
   Palermo; University of Palermo; UNICANCER; Institut Paoli-Calmette
   (IPC); Centre National de la Recherche Scientifique (CNRS); Institut
   National de la Sante et de la Recherche Medicale (Inserm); Aix-Marseille
   Universite
RP Cervello, M (corresponding author), CNR, Inst Biomed Res & Innovat IRIB, Palermo, Italy.
EM melchiorre.cervello@irib.cnr.it
RI Giannitrapani, Lydia/I-3706-2019; Cervello, Melchiorre/K-5080-2016; Di
   stefano, Vita/G-6889-2013; Seidita, Aurelio/IQT-5629-2023
OI Di Stefano, Vita/0000-0002-4483-2058; Augello,
   Giuseppa/0000-0001-6073-2789; Seidita, Aurelio/0000-0003-4080-2641
FU University of Palermo;  [08TP1041100162];  [IRIS/U GOV 16463]
FX This work was supported in part by the project n. 08TP1041100162 named
   TRIAL "Code IRIS/U GOV 16463" "PO FESR Sicilia 2014-2020" to LG.
   Publication costs supported in part by the FFR2021 fund of the
   University of Palermo assigned to MS.
CR Agostoni C, 2011, EFSA J, V9, DOI 10.2903/j.efsa.2011.2033
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Martín MA, 2010, MOL NUTR FOOD RES, V54, P956, DOI 10.1002/mnfr.200900159
   [Anonymous], 2007, Official Journal of the European Union
   Aparicio-Soto M, 2016, J NUTR BIOCHEM, V27, P278, DOI 10.1016/j.jnutbio.2015.09.017
   Aponte M, 2018, INT J PHARMACEUT, V543, P73, DOI 10.1016/j.ijpharm.2018.03.013
   Bravo-Herrera MD, 2004, NUTR METAB CARDIOVAS, V14, P128, DOI 10.1016/S0939-4753(04)80032-2
   Brenes M, 2002, J AGR FOOD CHEM, V50, P5962, DOI 10.1021/jf020506w
   Buchholz T, 2015, PLANTA MED, V81, P771, DOI 10.1055/s-0035-1546173
   Buckland G, 2012, BRIT J NUTR, V108, P2075, DOI 10.1017/S000711451200298X
   Calabriso N, 2016, J NUTR BIOCHEM, V28, P19, DOI 10.1016/j.jnutbio.2015.09.026
   Camargo A, 2010, BMC GENOMICS, V11, DOI 10.1186/1471-2164-11-253
   Carluccio MA, 2003, ARTERIOSCL THROM VAS, V23, P622, DOI 10.1161/01.ATV.0000062884.69432.A0
   Carnevale R, 2017, CLIN NUTR, V36, P782, DOI 10.1016/j.clnu.2016.05.016
   Caruso D, 2001, METABOLISM, V50, P1426, DOI 10.1053/meta.2001.28073
   Castro-Barquero S, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101523
   Corona G, 2006, FREE RADICAL RES, V40, P647, DOI 10.1080/10715760500373000
   Covas MI, 2006, ANN INTERN MED, V145, P333, DOI 10.7326/0003-4819-145-5-200609050-00006
   D'Alessandro A, 2015, NUTRIENTS, V7, P7863, DOI 10.3390/nu7095367
   D'Amore S, 2016, BBA-MOL CELL BIOL L, V1861, P1671, DOI 10.1016/j.bbalip.2016.07.003
   Davis CR, 2017, AM J CLIN NUTR, V105, P1305, DOI 10.3945/ajcn.116.146803
   de la Torre-Carbot K, 2010, J NUTR, V140, P501, DOI 10.3945/jn.109.112912
   De Santis S, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11020258
   De Santis S, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092085
   Delgado-Lista J, 2008, AM J CLIN NUTR, V87, P317, DOI 10.1093/ajcn/87.2.317
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Storniolo CE, 2014, REDOX BIOL, V2, P971, DOI 10.1016/j.redox.2014.07.001
   Emma MR, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22031234
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   European Community, 2012, COUNC REG 432 2012 1
   Fernández-Aparicio A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13103471
   Fitó M, 2008, EUR J CLIN NUTR, V62, P570, DOI 10.1038/sj.ejcn.1602724
   Foscolou A, 2018, MATURITAS, V118, P60, DOI 10.1016/j.maturitas.2018.10.013
   Fuentes F, 2001, ANN INTERN MED, V134, P1115, DOI 10.7326/0003-4819-134-12-200106190-00011
   Gardener H, 2011, AM J CLIN NUTR, V94, P1458, DOI 10.3945/ajcn.111.012799
   Guasch-Ferré M, 2014, BMC MED, V12, DOI 10.1186/1741-7015-12-78
   Gutierrez-Mariscal FM, 2012, AGE, V34, P389, DOI 10.1007/s11357-011-9229-1
   Hanhineva K, 2010, INT J MOL SCI, V11, P1365, DOI 10.3390/ijms11041365
   Zadeh SH, 2021, J GASTROEN HEPATOL, V36, P1470, DOI 10.1111/jgh.15363
   Hernáez A, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201601015
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Houttu V, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.716783
   Joshi AA., 2021, OLIVES OLIVE OIL HLT, pp. 261
   Jurado-Ruiz E, 2017, MOL NUTR FOOD RES, V61, DOI [10.1002/mnfr.201770034, 10.1002/mnfr.201600549]
   Karantonis HC, 2002, J AGR FOOD CHEM, V50, P1150, DOI 10.1021/jf010923t
   Kopel E, 2014, ANN INTERN MED, V161, P157, DOI [10.7326/L14-5014, 10.7326/M13-1725, 10.7326/L14-5014-2]
   Lama A, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600418
   Lasa A, 2014, EUR J CLIN NUTR, V68, P767, DOI 10.1038/ejcn.2014.1
   Llorente-Cortés V, 2010, ATHEROSCLEROSIS, V208, P442, DOI 10.1016/j.atherosclerosis.2009.08.004
   Loffredo L, 2017, BRIT J CLIN PHARMACO, V83, P96, DOI 10.1111/bcp.12923
   Lombardo L, 2018, STUD NAT PROD CHEM, V57, P41, DOI 10.1016/B978-0-444-64057-4.00002-8
   de las Hazas MCL, 2015, MOL NUTR FOOD RES, V59, P1395, DOI 10.1002/mnfr.201500048
   López-Yerena A, 2019, MOLECULES, V24, DOI 10.3390/molecules24101986
   Lozano-Castellón J, 2020, CRIT REV FOOD SCI, V60, P2532, DOI 10.1080/10408398.2019.1650715
   Manna C, 2000, FEBS LETT, V470, P341, DOI 10.1016/S0014-5793(00)01350-8
   Marin C, 2011, AM J CLIN NUTR, V93, P267, DOI 10.3945/ajcn.110.006866
   Mariotti M, 2014, EXTRA-VIRGIN OLIVE OIL HANDBOOK, P21
   Markellos C, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0261649
   Marx W, 2020, NUTR DIET, V77, P523, DOI 10.1111/1747-0080.12531
   Mazzocchi A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122941
   Menotti A, 2015, NUTR METAB CARDIOVAS, V25, P245, DOI 10.1016/j.numecd.2014.12.001
   Misciagna G, 2017, J NUTR HEALTH AGING, V21, P404, DOI 10.1007/s12603-016-0809-8
   Misikangas M, 2001, J NUTR, V131, P1700, DOI 10.1093/jn/131.6.1700
   Mosele JI, 2014, MOL NUTR FOOD RES, V58, P1809, DOI 10.1002/mnfr.201400124
   Ng CH, 2022, CLIN MOL HEPATOL, V28, P790, DOI 10.3350/cmh.2022.0070
   Njike VY, 2021, INT J CARDIOL, V330, P171, DOI 10.1016/j.ijcard.2021.01.062
   Papadaki A, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113342
   Pastor R, 2021, FREE RADICAL BIO MED, V172, P372, DOI 10.1016/j.freeradbiomed.2021.06.017
   Patti AM, 2020, METABOLITES, V10, DOI 10.3390/metabo10100392
   Perez-Martinez P, 2010, CLIN SCI, V119, P251, DOI 10.1042/CS20100015
   Pintó X, 2019, J NUTR, V149, P1920, DOI 10.1093/jn/nxz147
   Polari JJ, 2018, FOOD CHEM, V242, P362, DOI 10.1016/j.foodchem.2017.09.003
   Properzi C, 2018, HEPATOLOGY, V68, P1741, DOI 10.1002/hep.30076
   Quintero-Flórez A, 2018, EUR J NUTR, V57, P1925, DOI 10.1007/s00394-017-1475-2
   Romaguera D, 2010, AM J CLIN NUTR, V92, P912, DOI 10.3945/ajcn.2010.29482
   Romani A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081776
   Rosenzweig JL, 2019, J CLIN ENDOCR METAB, V104, P3939, DOI 10.1210/jc.2019-01338
   Rubió L, 2012, FOOD CHEM, V135, P2922, DOI 10.1016/j.foodchem.2012.07.085
   Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012
   Salas-Salvadó J, 2011, DIABETES CARE, V34, P14, DOI 10.2337/dc10-1288
   Sanchez-Villegas A., 2018, PREVENTION CARDIOVAS, pp. 59
   Sanders TAB, 2000, ATHEROSCLEROSIS, V149, P413, DOI 10.1016/S0021-9150(99)00335-4
   Santangelo C, 2018, ENDOCR METAB IMMUNE, V18, P36, DOI 10.2174/1871530317666171114114321
   Sarapis K, 2022, EUR J NUTR, V61, P1073, DOI 10.1007/s00394-021-02712-y
   Sarapis K, 2020, NUTRIENTS, V12, DOI 10.3390/nu12082272
   Schwingshackl L, 2017, NUTR DIABETES, V7, DOI 10.1038/nutd.2017.12
   Scoditti E, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102493
   Silva KDR, 2003, ATHEROSCLEROSIS, V166, P73, DOI 10.1016/S0021-9150(02)00306-4
   Soresi M, 2013, ACTA DIABETOL, V50, P241, DOI 10.1007/s00592-012-0406-1
   Stefania D, 2021, CRIT REV FOOD SCI, V61, P1804, DOI 10.1080/10408398.2020.1765736
   Storniolo CE, 2017, EUR J NUTR, V56, P89, DOI 10.1007/s00394-015-1060-5
   Mitjavila MT, 2013, CLIN NUTR, V32, P172, DOI 10.1016/j.clnu.2012.08.002
   Tsartsou E, 2019, FRONT NUTR, V6, DOI 10.3389/fnut.2019.00006
   Venkatakrishnan K, 2019, FOOD FUNCT, V10, P2313, DOI [10.1039/c9fo00293f, 10.1039/C9FO00293F]
   Venturini D, 2015, NUTRITION, V31, P834, DOI 10.1016/j.nut.2014.12.016
   Vicario IM, 1998, ANN NUTR METAB, V42, P160, DOI 10.1159/000012729
   Weinbrenner T, 2004, DRUG EXP CLIN RES, V30, P207
   Weinbrenner T, 2004, J NUTR, V134, P2314, DOI 10.1093/jn/134.9.2314
   Xiao JB, 2015, CURR MED CHEM, V22, P23
   Yubero-Serrano EM, 2019, EUR J CLIN NUTR, V72, P8, DOI 10.1038/s41430-018-0304-x
   Yubero-Serrano EM, 2011, AGE, V33, P579, DOI 10.1007/s11357-010-9199-8
   Zrelli H, 2011, J AGR FOOD CHEM, V59, P4473, DOI 10.1021/jf104151d
NR 102
TC 18
Z9 18
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD AUG 4
PY 2022
VL 9
AR 980429
DI 10.3389/fnut.2022.980429
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA M0LO5
UT WOS:001027117400001
PM 35990331
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cabrera, AG
   Caballero, P
   Wanden-Berghe, C
   Sanz-Lorente, M
   López-Pintor, E
AF Gea Cabrera, Alicia
   Caballero, Pablo
   Wanden-Berghe, Carmina
   Sanz-Lorente, Maria
   Lopez-Pintor, Elsa
TI Effectiveness of Workplace-Based Diet and Lifestyle Interventions on
   Risk Factors in Workers with Metabolic Syndrome: A Systematic Review,
   Meta-Analysis and Meta-Regression
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; occupational health; workplace; diet; food and
   nutrition; systematic review
ID PUBLICATION BIAS; HEALTH; PROGRAM; MANAGEMENT; DISEASE; IMPACT;
   ASSOCIATION; POPULATION; DEFINITION; PREVALENCE
AB Workplace health interventions are essential to improve the health and well-being of workers and promote healthy lifestyle behaviours. We carried out a systematic review, meta-analysis and meta-regression of articles measuring the association between workplace dietary interventions and MetS risk. We recovered potentially eligible studies by searching MEDLINE, the Cochrane Library, Embase, Scopus and Web of Science, using the terms "Metabolic syndrome" and "Occupational Health". A total of 311 references were retrieved and 13 documents were selected after applying the inclusion and exclusion criteria. Dietary interventions were grouped into six main types: basic education/counselling; specific diet/changes in diet and food intake; behavioural change/coaching; physical exercise; stress management; and internet/social networks. Most programmes included several components. The interventions considered together are beneficial, but the clinical results reflect only a minimal impact on MetS risk. According to the metaregression, the interventions with the greatest impact were those that used coaching techniques and those that promoted physical activity, leading to increased HDL (effect size = 1.58, sig = 0.043; and 2.02, 0.015, respectively) and decreased BMI (effect size = -0.79, sig = -0.009; and -0.77, 0.034, respectively). In contrast, interventions offering information on healthy habits and lifestyle had the contrary effect, leading to increased BMI (effect size = 0.78, sig = 0.006), systolic blood pressure (effect size = 4.85, sig = 0.038) and diastolic blood pressure (effect size = 3.34, sig = 0.001). It is necessary to improve the efficiency of dietary interventions aimed at lowering MetS risk in workers.
C1 [Gea Cabrera, Alicia; Lopez-Pintor, Elsa] Univ Miguel Hernandez, Dept Engn, Area Pharm & Pharmaceut Technol, Alicante 03550, Spain.
   [Caballero, Pablo] Univ Alicante, Dept Community Nursing Prevent Med & Publ Hlth &, Alicante 03690, Spain.
   [Wanden-Berghe, Carmina] Hosp Gen Univ Alicante, Grp Nutr Clin, Alicante 03010, Spain.
   [Wanden-Berghe, Carmina] Hosp Gen Univ Alicante, HAD, Inst Invest Sanit & Biomed Alicante ISABIA, Fdn FISABIO, Alicante 03010, Spain.
   [Sanz-Lorente, Maria] Univ Miguel Hernandez, Dept Publ Hlth & Hist Sci, Alicante 03550, Spain.
   [Lopez-Pintor, Elsa] CIBERESP, CIBER Epidemiol & Publ Hlth, Madrid 28029, Spain.
C3 Universidad Miguel Hernandez de Elche; Universitat d'Alacant; General
   University Hospital of Alicante; General University Hospital of
   Alicante; Universidad Miguel Hernandez de Elche; CIBER - Centro de
   Investigacion Biomedica en Red; CIBERESP
RP López-Pintor, E (corresponding author), Univ Miguel Hernandez, Dept Engn, Area Pharm & Pharmaceut Technol, Alicante 03550, Spain.; López-Pintor, E (corresponding author), CIBERESP, CIBER Epidemiol & Publ Hlth, Madrid 28029, Spain.
EM ali_ftca@hotmail.com; pablo.caballero@ua.es; carminaw@telefonica.net;
   msanzlor@gmail.com; elsa.lopez@umh.es
RI Caballero, Pablo/H-6457-2019
OI Caballero, Pablo/0000-0002-1234-2150; LOPEZ-PINTOR,
   ELSA/0000-0003-0937-5725
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Allen JC, 2012, PREV CHRONIC DIS, V9, DOI 10.5888/pcd9.110169
   Aracil-Lavado E., 2017, HOSP DOMIC, V1, P199, DOI [10.22585/hospdomic.v1i4.27, DOI 10.22585/HOSPDOMIC.V1I4.27]
   Balduzzi S, 2019, EVID-BASED MENT HEAL, V22, P153, DOI 10.1136/ebmental-2019-300117
   Baujat B, 2002, STAT MED, V21, P2641, DOI 10.1002/sim.1221
   Bhui K, 2016, BJPSYCH BULL, V40, P318, DOI 10.1192/pb.bp.115.050823
   Bodenheimer T, 2020, FAM SYST HEALTH, V38, P190, DOI 10.1037/fsh0000494
   Burgess E, 2017, CLIN OBES, V7, P105, DOI 10.1111/cob.12180
   Burton J., 2010, WHO HLTH WORKPLACE F
   Burton WN, 2008, J OCCUP ENVIRON MED, V50, P1139, DOI 10.1097/JOM.0b013e318188b8eb
   Castro-Barquero S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12102983
   Chen YC, 2013, TAIWAN J OBSTET GYNE, V52, P215, DOI 10.1016/j.tjog.2013.04.011
   Clifton P, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071438
   Cooper H., 2011, HDB RES SYNTHESES ME, P1
   Copas JB, 2001, STAT METHODS MED RES, V10, P251, DOI 10.1191/096228001678227776
   Dahal PK, 2019, AUST J PRIM HEALTH, V25, P526, DOI 10.1071/PY19007
   Duval S, 2000, J AM STAT ASSOC, V95, P89, DOI 10.2307/2669529
   Eftekhari S, 2021, J DIABETES METAB DIS, V20, P321, DOI 10.1007/s40200-021-00748-9
   Grundy SM, 2016, TRENDS CARDIOVAS MED, V26, P364, DOI 10.1016/j.tcm.2015.10.004
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Han TS, 1997, INT J OBESITY, V21, P127, DOI 10.1038/sj.ijo.0800377
   Harvard University School of Public Health, 2011, HLTH EAT PLAT HLTH E
   Haufe S, 2019, LANCET PUBLIC HEALTH, V4, pE343, DOI 10.1016/S2468-2667(19)30075-1
   Huang JH, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-13872-5
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Hwang LC, 2006, J FORMOS MED ASSOC, V105, P626, DOI 10.1016/S0929-6646(09)60161-3
   Inoue H, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-57
   Juvinyà-Canal D, 2018, GAC SANIT, V32, P8, DOI 10.1016/j.gaceta.2017.07.005
   Kempf K, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-022242
   Kramer MK, 2015, J OCCUP ENVIRON MED, V57, P284, DOI 10.1097/JOM.0000000000000350
   Lin CH, 2014, WORLDV EVID-BASED NU, V11, P361, DOI 10.1111/wvn.12069
   Luo DH, 2018, STAT METHODS MED RES, V27, P1785, DOI 10.1177/0962280216669183
   Malik VS, 2010, DIABETES CARE, V33, P2477, DOI 10.2337/dc10-1079
   Marks S, 2016, WORKPLACE HEALTH SAF, V64, P543, DOI 10.1177/2165079916634712
   Maruyama C, 2010, PREV MED, V51, P11, DOI 10.1016/j.ypmed.2010.04.008
   Marzusawa Y., 2005, J JPN SOC INT MED, V94, P188
   Mato VV, 2018, J OCCUP ENVIRON MED, V60, P368, DOI 10.1097/JOM.0000000000001128
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Nanri A, 2012, J OCCUP HEALTH, V54, P215, DOI 10.1539/joh.11-0238-OA
   Pandis N, 2017, BMJ-BRIT MED J, V357, DOI 10.1136/bmj.j2835
   Pelletier KR, 2011, J OCCUP ENVIRON MED, V53, P1310, DOI 10.1097/JOM.0b013e3182337748
   Pérez-Martínez P, 2017, NUTR REV, V75, P307, DOI 10.1093/nutrit/nux014
   PROCHASKA JO, 1983, J CONSULT CLIN PSYCH, V51, P390, DOI 10.1037//0022-006X.51.3.390
   Proeschold-Bell RJ, 2017, AM J PREV MED, V53, P290, DOI 10.1016/j.amepre.2017.04.009
   Puhkala J, 2015, SCAND J WORK ENV HEA, V41, P54, DOI 10.5271/sjweh.3463
   Racette SB, 2009, PREV MED, V49, P108, DOI 10.1016/j.ypmed.2009.06.022
   Rahimi K, 2021, LANCET, V397, P1625, DOI 10.1016/S0140-6736(21)00590-0
   Rosenstock I., 1990, Health Behavior and Health Education: Theory, Research, and Practice
   Ryo M, 2011, INTERNAL MED, V50, P1643, DOI 10.2169/internalmedicine.50.5039
   Saboya PP, 2017, ARQ BRAS CARDIOL, V108, P60, DOI 10.5935/abc.20160186
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Schultz AB, 2010, VALUE HEALTH, V13, P258, DOI 10.1111/j.1524-4733.2009.00651.x
   Schultz AB, 2009, J OCCUP ENVIRON MED, V51, P771, DOI 10.1097/JOM.0b013e3181a88da5
   Schwarzer G., **DATA OBJECT**
   Shrivastava U, 2017, J DIABETES RES, V2017, DOI 10.1155/2017/7254174
   Singh IM, 2007, JAMA-J AM MED ASSOC, V298, P786, DOI 10.1001/jama.298.7.786
   Steinberg G, 2015, J OCCUP ENVIRON MED, V57, P1269, DOI 10.1097/JOM.0000000000000582
   Sun K, 2014, CLIN NUTR, V33, P596, DOI 10.1016/j.clnu.2013.10.003
   The European Programme FOOD (Fighting Obesity through Offer and Demand), 2011, BAL NUTR WORK C REP
   Thom DH, 2013, ANN FAM MED, V11, P137, DOI 10.1370/afm.1443
   Tsai HH, 2013, IND HEALTH, V51, P336, DOI 10.2486/indhealth.2012-0188
   van Namen M, 2019, METABOLISM, V101, DOI 10.1016/j.metabol.2019.153988
   Wan X, 2014, BMC MED RES METHODOL, V14, DOI 10.1186/1471-2288-14-135
   Wanden-Berghe C, 2012, BRIT J NUTR, V107, pS3, DOI 10.1017/S0007114512001432
   Williams R.B., 2006, CONTROL NO MORE SNAP
   Woo SH, 2020, WORKPLACE HEALTH SAF, V68, P109, DOI 10.1177/2165079919864976
   World Health Organization, 2004, Global Strategy on Diet, Physical Activity and Health
   Yamaoka K, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-138
NR 69
TC 16
Z9 17
U1 1
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2021
VL 13
IS 12
AR 4560
DI 10.3390/nu13124560
PG 31
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA XX9WW
UT WOS:000736637200001
PM 34960112
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hao, H
   Guo, H
   Ma, RL
   Yan, YZ
   Hu, YH
   Ma, JL
   Zhang, XH
   Wang, XP
   Wang, K
   Mu, LT
   Song, YP
   Zhang, JY
   He, J
   Guo, SX
AF Hao, Hao
   Guo, Heng
   Ma, Ru-lin
   Yan, Yi-zhong
   Hu, Yun-hua
   Ma, Jiao-long
   Zhang, Xiang-hui
   Wang, Xin-ping
   Wang, Kui
   Mu, La-ti
   Song, Yan-peng
   Zhang, Jing-yu
   He, Jia
   Guo, Shu-xia
TI Association of total bilirubin and indirect bilirubin content with
   metabolic syndrome among Kazakhs in Xinjiang
SO BMC ENDOCRINE DISORDERS
LA English
DT Article
DE Bilirubin; Transaminase; Metabolic syndrome
ID ALANINE AMINOTRANSFERASE; DISEASE; STRESS; PLASMA; RISK; MEN
AB Background Some studies have shown that a high level of bilirubin is a protective factor against metabolic syndrome (MS), while a high level of transaminase is a risk factor for MS. However, the existing results are inconsistent and few cohort studies have been published. Methods Using an ambispective cohort study, 565 Kazakhs from Xinjiang, China were selected as the study subjects. The baseline serum bilirubin and transaminase levels of the subjects were divided into quartiles and the relationship between these values and the incidence of MS was analyzed. The definition of MS was based on the Joint Interim Statement (JIS) diagnostic criteria. Results The average follow-up time for the subjects was 5.72 years. The cumulative incidence of MS was 36.11% (204 of the 565 subjects), and the incidence density was 63.10/1000 person-years. Multivariate Cox regression analysis showed that the levels of total bilirubin (TBIL) and indirect bilirubin (IBIL) were negatively correlated with the occurrence of MS, Compared to the lowest quartile level (Q1), the hazard ratios of MS the TBIL levels at the Q2-Q4 quartiles were: 0.47 (0.31-0.71), 0.53 (0.35-0.79), and 0.48 (0.32-0.72), respectively, while IBIL levels at the Q2-Q4 quartiles showed an MS hazard ratio of 0.48 (0.32-0.72), 0.54(0.36-0.81), and 0.52 (0.35-0.77), respectively, all at a 95% confidence level. However, no relationship was found between transaminase levels and the incidence of MS. Conclusion Serum TBIL and IBIL levels were negatively correlated with the incidence of MS in a Kazakh population in China.
C1 [Hao, Hao; Guo, Heng; Ma, Ru-lin; Yan, Yi-zhong; Hu, Yun-hua; Ma, Jiao-long; Zhang, Xiang-hui; Wang, Xin-ping; Wang, Kui; Mu, La-ti; Song, Yan-peng; Zhang, Jing-yu; He, Jia; Guo, Shu-xia] Shihezi Univ, Dept Publ Hlth, Sch Med, Shihezi 832000, Xinjiang, Peoples R China.
   [Song, Yan-peng] Shihezi Univ, Affiliated Hosp 1, Coll Med, Shihezi 832000, Xinjiang, Peoples R China.
   [Guo, Shu-xia] Shihezi Univ, Sch Med, Minist Educ, Dept Pathol, Shihezi 832000, Xinjiang, Peoples R China.
   [Guo, Shu-xia] Shihezi Univ, Sch Med, Minist Educ, Key Lab Xinjiang Endem & Ethn Dis, Shihezi 832000, Xinjiang, Peoples R China.
C3 Shihezi University; Shihezi University; Ministry of Education - China;
   Shihezi University; Shihezi University; Ministry of Education - China
RP He, J; Guo, SX (corresponding author), Shihezi Univ, Dept Publ Hlth, Sch Med, Shihezi 832000, Xinjiang, Peoples R China.
EM hejia123.shihezi@163.com; gsxshzu@sina.com
RI Zhang, Jingyu/HOF-5633-2023; Guo, Shuxia/Y-4219-2018
OI Yan, Yizhong/0000-0003-1957-5421; Zhang, XiangHui/0000-0002-1829-1681
FU National Natural Science Foundation of China [81560551]; Shihezi
   University Innovation Outstanding Young Talents Program (Natural
   Science) [CXPY201908]
FX This study was funded by the National Natural Science Foundation of
   China (no. 81560551) and the Shihezi University Innovation Outstanding
   Young Talents Program (Natural Science) (no. CXPY201908). The funders
   played no role in the design of this study, the collection, analysis and
   interpretation of data or preparation of the manuscript.
CR Boon AC, 2015, FREE RADICAL BIO MED, V86, P259, DOI 10.1016/j.freeradbiomed.2015.05.031
   Boon AC, 2014, AM J PHYSIOL-RENAL, V307, pF123, DOI 10.1152/ajprenal.00039.2014
   Bulmer AC, 2013, PROG LIPID RES, V52, P193, DOI 10.1016/j.plipres.2012.11.001
   Cheriyath Pramil, 2010, J Clin Med Res, V2, P201, DOI 10.4021/jocmr425w
   Dong HS, 2014, ENDOCRINOLOGY, V155, P818, DOI 10.1210/en.2013-1667
   Gazzin S, 2016, TRENDS MOL MED, V22, P758, DOI 10.1016/j.molmed.2016.07.004
   Guo SX, 2016, SCI REP-UK, V6, DOI 10.1038/srep36091
   Huang SS, 2015, AM J MED, V128, DOI 10.1016/j.amjmed.2015.04.019
   Hwang JH, 2013, J KOREAN MED SCI, V28, P1768, DOI 10.3346/jkms.2013.28.12.1768
   Kawamoto R, 2019, DIABETES METAB SYND, V13, P1329, DOI 10.1016/j.dsx.2019.02.009
   Lee SH, 2018, TURK J GASTROENTEROL, V29, P52, DOI 10.5152/tjg.2018.17333
   Li XH, 2017, BIOMED RES INT, V2017, DOI 10.1155/2017/9621615
   Lin JP, 2010, CLIN CHEM, V56, P1535, DOI 10.1373/clinchem.2010.151043
   Maruhashi T, 2012, CIRCULATION, V126, P598, DOI 10.1161/CIRCULATIONAHA.112.105775
   Mazzone GL, 2009, BIOCHEM BIOPH RES CO, V386, P338, DOI 10.1016/j.bbrc.2009.06.029
   McCarty MF, 2007, MED HYPOTHESES, V69, P974, DOI 10.1016/j.mehy.2006.12.069
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   Mendrick DL, 2018, TOXICOL SCI, V162, P36, DOI 10.1093/toxsci/kfx233
   NEUZIL J, 1994, J BIOL CHEM, V269, P16712
   Oda E, 2013, ACTA DIABETOL, V50, P417, DOI 10.1007/s00592-012-0447-5
   Pei D, 2015, SAUDI J GASTROENTERO, V21, P158, DOI 10.4103/1319-3767.157564
   Peng YF, 2016, J CLIN LAB ANAL, V30, P982, DOI 10.1002/jcla.21967
   Schindhelm RK, 2007, ATHEROSCLEROSIS, V191, P391, DOI 10.1016/j.atherosclerosis.2006.04.006
   Shiraishi M, 2019, DIABETOL METAB SYNDR, V11, DOI 10.1186/s13098-019-0408-z
   Shuxia G, 2011, CHIN J HYPERTENSION, V19, P538
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Sun HG, 2019, CLIN CHIM ACTA, V488, P242, DOI 10.1016/j.cca.2018.10.033
   Sundararaghavan VL, 2018, TRANSPLANT REV-ORLAN, V32, P234, DOI 10.1016/j.trre.2018.06.003
   Takei R, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0223302
   Vítek L, 2012, FRONT PHARMACOL, V3, DOI 10.3389/fphar.2012.00055
   Vona R, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8267234
   Wagner KH, 2015, CLIN SCI, V129, P1, DOI 10.1042/CS20140566
   Wang S, 2017, SCI REP-UK, V7, DOI 10.1038/srep44844
   Wu Tai-Wing, 1994, Life Sciences, V54, pPL477, DOI 10.1016/0024-3205(94)90140-6
   Zhang XM, 2017, IEEE T IND INFORM, V13, P4, DOI 10.1109/TII.2016.2607150
   Zhao XJ, 2019, MEDIAT INFLAMM, V2019, DOI 10.1155/2019/5256460
   Zhou JA, 2017, MOL MED REP, V16, P1779, DOI 10.3892/mmr.2017.6825
NR 37
TC 11
Z9 12
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6823
J9 BMC ENDOCR DISORD
JI BMC Endocr. Disord.
PD JUL 22
PY 2020
VL 20
IS 1
AR 110
DI 10.1186/s12902-020-00563-y
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA MT5WH
UT WOS:000555044800003
PM 32698889
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Moreno-Viedma, V
   Amor, M
   Sarabi, A
   Bilban, M
   Staffler, G
   Zeyda, M
   Stulnig, M
AF Moreno-Viedma, V.
   Amor, M.
   Sarabi, A.
   Bilban, M.
   Staffler, G.
   Zeyda, M.
   Stulnig, M.
TI Common dysregulated pathways in obese adipose tissue and atherosclerosis
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Cardiovascular diseases; Diabetes mellitus; type 2; Insulin resistance;
   Atherosclerosis; Pathway analysis
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; RT-PCR; INFLAMMATION; MICROARRAY;
   GENES; EXPRESSION; PROTEINS; BIOLOGY
AB Background: The metabolic syndrome is becoming increasingly prevalent in the general population that is at simultaneous risk for both type 2 diabetes and cardiovascular disease. The critical pathogenic mechanisms underlying these diseases are obesity-driven insulin resistance and atherosclerosis, respectively. To obtain a better understanding of molecular mechanisms involved in pathogenesis of the metabolic syndrome as a basis for future treatment strategies, studies considering both inherent risks, namely metabolic and cardiovascular, are needed. Hence, the aim of this study was to identify pathways commonly dysregulated in obese adipose tissue and atherosclerotic plaques.
   Methods: We carried out a gene set enrichment analysis utilizing data from two microarray experiments with obese white adipose tissue and atherosclerotic aortae as well as respective controls using a combined insulin resistance-atherosclerosis mouse model.
   Results: We identified 22 dysregulated pathways common to both tissues with p values below 0.05, and selected inflammatory response and oxidative phosphorylation pathways from the Hallmark gene set to conduct a deeper evaluation at the single gene level. This analysis provided evidence of a vast overlap in gene expression alterations in obese adipose tissue and atherosclerosis with Il7r, C3ar1, Tlr1, Rgs1 and Semad4d being the highest ranked genes for the inflammatory response pathway and Maob, Bckdha, Aldh6a1, Echs1 and Cox8a for the oxidative phosphorylation pathway.
   Conclusions: In conclusion, this study provides extensive evidence for common pathogenic pathways underlying obesity-driven insulin resistance and atherogenesis which could provide a basis for the development of novel strategies to simultaneously prevent type 2 diabetes and cardiovascular disease in patients with metabolic syndrome.
C1 [Moreno-Viedma, V.; Amor, M.; Sarabi, A.; Zeyda, M.; Stulnig, M.] Med Univ Vienna, Christian Doppler Lab Cardiometabol Immunotherapy, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
   [Moreno-Viedma, V.; Amor, M.; Sarabi, A.; Zeyda, M.; Stulnig, M.] Med Univ Vienna, Clin Div Endocrinol & Metab, Dept Med 3, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
   [Bilban, M.] Med Univ Vienna, Dept Lab Med, Vienna, Austria.
   [Bilban, M.] Med Univ Vienna, Core Facil Genom, Core Facil, Vienna, Austria.
   [Staffler, G.] AFFiRiS AG, Vienna, Austria.
   [Zeyda, M.] Med Univ Vienna, Dept Pediat & Adolescent Med, Clin Div Pediat Pulmonol Allergol & Endocrinol, Vienna, Austria.
C3 Medical University of Vienna; Medical University of Vienna; Medical
   University of Vienna; Medical University of Vienna; Medical University
   of Vienna
RP Stulnig, M (corresponding author), Med Univ Vienna, Christian Doppler Lab Cardiometabol Immunotherapy, Waehringer Guertel 18-20, A-1090 Vienna, Austria.; Stulnig, M (corresponding author), Med Univ Vienna, Clin Div Endocrinol & Metab, Dept Med 3, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
EM thomas.stulnig@meduniwien.ac.at
RI Amor, Melina/AAF-3276-2021; Moreno-Viedma, Verónica/AAC-8685-2022
OI Moreno-Viedma, Veronica/0000-0003-0906-8725; Moreno Viedma,
   Veronica/0000-0003-1934-1692; Zeyda, Maximilian/0000-0001-5000-1974;
   Stulnig, Thomas/0000-0003-3300-6161; Bilban, Martin/0000-0001-7043-7142;
   Amor, Melina/0000-0002-2799-5322
FU Federal Ministry of Economy, Family and Youth; National Foundation for
   Research, Technology and Development
FX This work was supported by the Federal Ministry of Economy, Family and
   Youth and the National Foundation for Research, Technology and
   Development. (to T.M.S.).
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Allanach K, 2008, AM J TRANSPLANT, V8, P1006, DOI 10.1111/j.1600-6143.2008.02199.x
   [Anonymous], INT J OBES LOND
   Balkau B, 2003, DIABETES METAB, V29, P526, DOI 10.1016/S1262-3636(07)70067-8
   Curtis RK, 2005, TRENDS BIOTECHNOL, V23, P429, DOI 10.1016/j.tibtech.2005.05.011
   Dahlman I, 2006, DIABETES, V55, P1792, DOI 10.2337/db05-1421
   Donath MY, 2011, NAT REV IMMUNOL, V11, P98, DOI 10.1038/nri2925
   Draghici S, 2007, GENOME RES, V17, P1537, DOI 10.1101/gr.6202607
   Etienne W, 2004, BIOTECHNIQUES, V36, P618, DOI 10.2144/04364ST02
   Festa A, 2002, DIABETES, V51, P1131, DOI 10.2337/diabetes.51.4.1131
   Fu Y, 2015, LAB INVEST
   Gentleman RC, 2004, GENOME BIOL, V5, DOI 10.1186/gb-2004-5-10-r80
   Grundy SM, 2015, EUR J CLIN INVEST, V45, P1209, DOI 10.1111/eci.12519
   Huber W, 2015, NAT METHODS, V12, P115, DOI [10.1038/NMETH.3252, 10.1038/nmeth.3252]
   Kaptoge S, 2012, NEW ENGL J MED, V367, P1310, DOI 10.1056/NEJMoa1107477
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Khatri P, 2012, PLOS COMPUT BIOL, V8, DOI 10.1371/journal.pcbi.1002375
   King JY, 2005, PHYSIOL GENOMICS, V23, P103, DOI 10.1152/physiolgenomics.00101.2005
   Kondo T, 2009, J ATHEROSCLER THROMB, V16, P532, DOI 10.5551/jat.1255
   Liu KQ, 2012, BMC BIOINFORMATICS, V13, DOI 10.1186/1471-2105-13-126
   Liu YL, 2013, BMC MED GENOMICS, V6, DOI 10.1186/1755-8794-6-S1-S17
   Lumeng CN, 2011, J CLIN INVEST, V121, P2111, DOI 10.1172/JCI57132
   Messner B, 2011, ATHEROSCLEROSIS, V219, P402, DOI 10.1016/j.atherosclerosis.2011.05.025
   Mootha VK, 2003, NAT GENET, V34, P267, DOI 10.1038/ng1180
   Munasinghe PE, 2016, INT J CARDIOL, V202, P13, DOI 10.1016/j.ijcard.2015.08.111
   Neuhofer A, 2014, CARDIOVASC DIABETOL, V13, DOI 10.1186/1475-2840-13-23
   O'Rourke RW, 2013, SURG OBES RELAT DIS, V9, P609, DOI 10.1016/j.soard.2012.07.010
   O'Rourke RW, 2009, SURGERY, V145, P255, DOI 10.1016/j.surg.2008.08.038
   Pal S, 2010, OBESITY, V18, P1354, DOI 10.1038/oby.2009.397
   Park HS, 2005, DIABETES RES CLIN PR, V69, P29, DOI 10.1016/j.diabres.2004.11.007
   Pradhan AD, 2002, EUR HEART J, V23, P831, DOI 10.1053/euhj.2001.3052
   Ridker PM, 2014, EUR HEART J, V35, P1782, DOI 10.1093/eurheartj/ehu203
   Rocha VZ, 2009, NAT REV CARDIOL, V6, P399, DOI 10.1038/nrcardio.2009.55
   Rochette L, 2014, BBA-GEN SUBJECTS, V1840, P2709, DOI 10.1016/j.bbagen.2014.05.017
   Sato M, 2014, DIABETES, V63, P4115, DOI 10.2337/db13-1860
   Shim Unjin, 2014, Genomics & Informatics, V12, P195, DOI 10.5808/GI.2014.12.4.195
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Subramanian A, 2005, P NATL ACAD SCI USA, V102, P15545, DOI 10.1073/pnas.0506580102
   Sun SY, 2012, ANNU REV NUTR, V32, P261, DOI 10.1146/annurev-nutr-071811-150623
   Wurmbach E, 2001, J BIOL CHEM, V276, P47195, DOI 10.1074/jbc.M108716200
   Xing SS, 2015, VASC PHARMACOL, V72, P141, DOI 10.1016/j.vph.2015.07.004
   Zahorska-Merkiewicz B, 1999, J ENDOCRINOL INVE S7, V22, P66
   Zhang L, 2015, MOL MED REP, V11, P1963, DOI 10.3892/mmr.2014.2909
   Zhou MS, 2015, CARDIOVASC DIABETOL, V14, DOI 10.1186/s12933-015-0211-6
NR 44
TC 40
Z9 45
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD AUG 26
PY 2016
VL 15
AR 120
DI 10.1186/s12933-016-0441-2
PG 12
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA DW7NP
UT WOS:000383838100001
PM 27561966
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kapravelou, G
   Martínez, R
   Andrade, AM
   Nebot, E
   Camiletti-Moirón, D
   Aparicio, VA
   Lopez-Jurado, M
   Aranda, P
   Arrebola, F
   Fernandez-Segura, E
   Bermano, G
   Goua, M
   Galisteo, M
   Porres, JM
AF Kapravelou, Garyfallia
   Martinez, Rosario
   Andrade, Ana M.
   Nebot, Elena
   Camiletti-Moiron, Daniel
   Aparicio, Virginia A.
   Lopez-Jurado, Maria
   Aranda, Pilar
   Arrebola, Francisco
   Fernandez-Segura, Eduardo
   Bermano, Giovanna
   Goua, Marie
   Galisteo, Milagros
   Porres, Jesus M.
TI Aerobic interval exercise improves parameters of nonalcoholic fatty
   liver disease (NAFLD) and other alterations of metabolic syndrome in
   obese Zucker rats
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE metabolic syndrome; nonalcoholic fatty liver disease; aerobic interval
   training; aerobic capacity; lipid metabolism; hepatic metabolic
   pathways; liver antioxidant status
ID CONTINUOUS MODERATE EXERCISE; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   INTENSITY; DIET; STEATOHEPATITIS; EXPRESSION; MUSCLE; ATHEROSCLEROSIS;
   DYSFUNCTION
AB Metabolic syndrome (MS) is a group of metabolic alterations that increase the susceptibility to cardiovascular disease and type 2 diabetes. Nonalcoholic fatty liver disease has been described as the liver manifestation of MS. We aimed to test the beneficial effects of an aerobic interval training (AIT) protocol on different biochemical, microscopic, and functional liver alterations related to the MS in the experimental model of obese Zucker rat. Two groups of lean and obese animals (6 weeks old) followed a protocol of AIT (4 min at 65%-80% of maximal oxygen uptake, followed by 3 min at 50%-65% of maximal oxygen uptake for 45-60 min, 5 days/week, 8 weeks of experimental period), whereas 2 control groups remained sedentary. Obese rats had higher food intake and body weight (P < 0.0001) and suffered significant alterations in plasma lipid profile, area under the curve after oral glucose overload (P < 0.0001), liver histology and functionality, and antioxidant status. The AIT protocol reduced the severity of alterations related to glucose and lipid metabolism and increased the liver protein expression of PPAR gamma, as well as the gene expression of glutathione peroxidase 4 (P < 0.001). The training protocol also showed significant effects on the activity of hepatic antioxidant enzymes, although this action was greatly influenced by rat phenotype. The present data suggest that AIT protocol is a feasible strategy to improve some of the plasma and liver alterations featured by the MS.
C1 [Kapravelou, Garyfallia; Martinez, Rosario; Andrade, Ana M.; Nebot, Elena; Camiletti-Moiron, Daniel; Aparicio, Virginia A.; Lopez-Jurado, Maria; Aranda, Pilar; Porres, Jesus M.] Univ Granada, Inst Nutr & Food Technol, Dept Physiol, Doctoral Program Nutr & Food Sci, E-18071 Granada, Spain.
   [Arrebola, Francisco; Fernandez-Segura, Eduardo] Univ Granada, Dept Histol, Inst Neurosci, E-18071 Granada, Spain.
   [Bermano, Giovanna; Goua, Marie] Robert Gordon Univ, Inst Hlth & Wellbeing Res, Aberdeen AB10 7GJ, Scotland.
   [Galisteo, Milagros] Univ Granada, Sch Pharm, Dept Pharmacol, E-18071 Granada, Spain.
C3 University of Granada; University of Granada; Robert Gordon University;
   University of Granada
RP Porres, JM (corresponding author), Univ Granada, Inst Nutr & Food Technol, Dept Physiol, Doctoral Program Nutr & Food Sci, Campus Univ Cartuja S-N, E-18071 Granada, Spain.
EM jmporres@ugr.es
RI Camiletti-Moirón, Daniel/Q-7424-2016; Arrebola Vargas,
   Francisco/L-9108-2014; Fernandezsegura, Eduardo/F-3756-2016; Goua,
   Marie/J-8104-2019; Martinez, Rosario/K-7712-2017; Kapravelou,
   Garyfallia/K-8635-2017; Aranda Ramirez, Pilar/B-8037-2016; Aparicio,
   Virginia A/D-9666-2016; Nebot Valenzuela, Elena/M-2561-2014; Porres
   Foulquie, Jesus Maria/B-6442-2018
OI Martinez, Rosario/0000-0003-2032-1621; Kapravelou,
   Garyfallia/0000-0001-8414-9723; Aranda Ramirez,
   Pilar/0000-0002-7982-1359; Bermano, Giovanna/0000-0001-6027-6437;
   Aparicio, Virginia A/0000-0002-2867-378X; Nebot Valenzuela,
   Elena/0000-0001-9689-6945; Goua, Marie/0000-0003-1609-4366; Porres
   Foulquie, Jesus Maria/0000-0001-5657-0764; Camiletti Moiron,
   Daniel/0000-0002-8856-5967
FU Junta de Andalucia, Spain [P09-AGR-4658]; Institute for Health and
   Wellbeing Research; European Union [AGL2013-43247-R]
FX We want to thank Encarnacion Rebollo and Lucia Bustos for skillful
   technical assistance. This study was funded by grant P09-AGR-4658 from
   Junta de Andalucia, Spain, and is part of the PhD thesis of Garyfallia
   Kapravelou, entitled "Effects of legume protein hydrolyzates on lipid
   metabolism in an obese rat experimental model. Interaction with aerobic
   physical exercise." Gene expression work was carried out at Robert
   Gordon University and was funded by the Institute for Health and
   Wellbeing Research. The authors also want to acknowledge the Ministry of
   Economy and Competitiveness (MINECO, Spain) and the European Union
   through project no. AGL2013-43247-R and FEDER program, respectively.
CR Aebi H, 1984, Methods Enzymol, V105, P121
   Al Rifai M, 2015, ATHEROSCLEROSIS, V239, P629, DOI 10.1016/j.atherosclerosis.2015.02.011
   Angelico F, 2005, J CLIN ENDOCR METAB, V90, P1578, DOI 10.1210/jc.2004-1024
   Astorino TA, 2013, MED SCI SPORT EXER, V45, P1878, DOI 10.1249/MSS.0b013e3182936261
   Barker AR, 2014, J SPORT SCI, V32, P757, DOI 10.1080/02640414.2013.853132
   BERMANO G, 1995, BIOCHEM J, V311, P425, DOI 10.1042/bj3110425
   Brunt EM, 2010, WORLD J GASTROENTERO, V16, P5286, DOI 10.3748/wjg.v16.i42.5286
   Clemente VJC, 2011, ARCH MED DEP, V143, P168
   Daussin FN, 2012, MED SCI SPORT EXER, V44, P217, DOI 10.1249/MSS.0b013e31822b0bd4
   Desai S, 2014, LIVER INT, V34, P110, DOI 10.1111/liv.12308
   Donnelly JE, 2009, MED SCI SPORT EXER, V41, P459, DOI 10.1249/MSS.0b013e3181949333
   EUC, 2010, OFFICIAL J EUROPEAN
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   Galisteo M, 2008, J NUTR BIOCHEM, V19, P71, DOI 10.1016/j.jnutbio.2007.02.009
   Galisteo M, 2010, CLIN NUTR, V29, P261, DOI 10.1016/j.clnu.2009.08.011
   Gonçalves IO, 2014, MITOCHONDRION, V15, P40, DOI 10.1016/j.mito.2014.03.012
   Grundy SM, 2005, ARTERIOSCL THROM VAS, V25, P2243, DOI 10.1161/01.ATV.0000189155.75833.c7
   Guo Z, 2008, FREE RADICAL BIO MED, V44, P343, DOI 10.1016/j.freeradbiomed.2007.09.009
   Haram PM, 2009, CARDIOVASC RES, V81, P723, DOI 10.1093/cvr/cvn332
   Haus JM, 2013, J CLIN ENDOCR METAB, V98, pE1181, DOI 10.1210/jc.2013-1229
   Hey-Mogensen M, 2012, ACTA PHYSIOL, V204, P354, DOI 10.1111/j.1748-1716.2011.02347.x
   Huang CC, 2013, MOLECULES, V18, P1741, DOI 10.3390/molecules18021741
   Imai H, 2003, FREE RADICAL BIO MED, V34, P145, DOI 10.1016/S0891-5849(02)01197-8
   Jenkins NT, 2009, AM J PHYSIOL-HEART C, V297, pH1798, DOI 10.1152/ajpheart.00347.2009
   Jiang HK, 2014, INT J MOL SCI, V15, P5304, DOI 10.3390/ijms15045304
   Johnson NA, 2009, HEPATOLOGY, V50, P1105, DOI 10.1002/hep.23129
   Jung JH, 2013, FOOD CHEM TOXICOL, V60, P404, DOI 10.1016/j.fct.2013.07.048
   Juraschek SP, 2013, ANN EPIDEMIOL, V23, P791, DOI 10.1016/j.annepidem.2013.09.005
   Kapravelou G, 2013, FOOD RES INT, V54, P1471, DOI 10.1016/j.foodres.2013.10.019
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kibenge MT, 2002, METABOLISM, V51, P708, DOI 10.1053/meta.2002.32727
   Kistler KD, 2011, AM J GASTROENTEROL, V106, P460, DOI 10.1038/ajg.2010.488
   Kucera O, 2014, WORLD J GASTROENTERO, V20, P8364, DOI 10.3748/wjg.v20.i26.8364
   Larsen S, 2015, SCAND J MED SCI SPOR, V25, pE59, DOI 10.1111/sms.12252
   LAWRENCE RA, 1974, EXP EYE RES, V18, P563, DOI 10.1016/0014-4835(74)90062-1
   Lee S, 2013, AM J PHYSIOL-ENDOC M, V305, pE1222, DOI 10.1152/ajpendo.00285.2013
   Linden MA, 2015, MED SCI SPORT EXER, V47, P556, DOI 10.1249/MSS.0000000000000430
   Lochhead PA, 2000, DIABETES, V49, P896, DOI 10.2337/diabetes.49.6.896
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   Marchesini G, 2003, HEPATOLOGY, V37, P917, DOI 10.1053/jhep.2003.50161
   Metz L, 2005, BIOCHEM BIOPH RES CO, V331, P1338, DOI 10.1016/j.bbrc.2005.04.054
   Morris EM, 2014, AM J PHYSIOL-ENDOC M, V307, pE355, DOI 10.1152/ajpendo.00093.2014
   Morris RT, 2007, J AM SOC HYPERTENS, V1, P393, DOI 10.1016/j.jash.2007.09.001
   National Research Council, 1995, Nutrient requirements of laboratory animals, V4th ed., DOI 10.17226/4758
   Neuschwander-Tetri BA, 2003, HEPATOLOGY, V38, P1008, DOI 10.1053/jhep.2003.50420
   Ogonovszky H, 2005, CAN J APPL PHYSIOL, V30, P186, DOI 10.1139/h05-114
   Polyzos SA, 2009, CURR MOL MED, V9, P299, DOI 10.2174/156652409787847191
   Praphatsorn P, 2010, ASIAN BIOMED, V4, P619, DOI 10.2478/abm-2010-0078
   Prieto PG, 2004, J AM COLL NUTR, V23, P414, DOI 10.1080/07315724.2004.10719386
   Qi ZT, 2011, FREE RADICAL BIO MED, V50, P794, DOI 10.1016/j.freeradbiomed.2010.12.022
   Ramos D, 2013, APPL PHYSIOL NUTR ME, V38, P507, DOI 10.1139/apnm-2012-0302
   Reaven G, 2004, ENDOCRIN METAB CLIN, V33, P283, DOI 10.1016/j.ecl.2004.03.002
   REEVES PG, 1993, J NUTR, V123, P1939, DOI 10.1093/jn/123.11.1939
   Ristow M, 2009, P NATL ACAD SCI USA, V106, P8665, DOI 10.1073/pnas.0903485106
   Rivera L, 2009, BIOCHEM PHARMACOL, V77, P1053, DOI 10.1016/j.bcp.2008.11.027
   Rolo AP, 2012, FREE RADICAL BIO MED, V52, P59, DOI 10.1016/j.freeradbiomed.2011.10.003
   Rosety-Rodriguez M, 2012, MED SCI MONITOR, V18, pBR346, DOI 10.12659/MSM.883343
   Sasaki T, 2014, AM J PHYSIOL-ENDOC M, V306, pE1085, DOI 10.1152/ajpendo.00691.2013
   Shin YA, 2008, MECH AGEING DEV, V129, P254, DOI 10.1016/j.mad.2008.01.001
   Sneddon AA, 2003, ATHEROSCLEROSIS, V171, P57, DOI 10.1016/j.atherosclerosis.2003.08.008
   Soltys K, 2001, HEPATOLOGY, V34, P13, DOI 10.1053/jhep.2001.25452
   Souto G, 2011, METAB SYNDR RELAT D, V9, P247, DOI 10.1089/met.2010.0108
   Souza-Mello V, 2015, WORLD J HEPATOL, V7, P1012, DOI 10.4254/wjh.v7.i8.1012
   Sullivan S, 2012, HEPATOLOGY, V55, P1738, DOI 10.1002/hep.25548
   Tariq Z, 2014, LIVER INT, V34, pE180, DOI 10.1111/liv.12523
   Tjonna AE, 2008, CIRCULATION, V118, P346, DOI 10.1161/CIRCULATIONAHA.108.772822
   Ukeda H, 1997, ANAL BIOCHEM, V251, P206, DOI 10.1006/abio.1997.2273
   Videla LA, 2004, CLIN SCI, V106, P261, DOI 10.1042/CS20030285
   Wisloff U, 2001, AM J PHYSIOL-HEART C, V280, pH1301, DOI 10.1152/ajpheart.2001.280.3.H1301
NR 69
TC 28
Z9 30
U1 1
U2 29
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD DEC
PY 2015
VL 40
IS 12
BP 1242
EP 1252
DI 10.1139/apnm-2015-0141
PG 11
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA CY3VH
UT WOS:000366337500003
PM 26509584
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Nagase, M
   Fujita, T
AF Nagase, Miki
   Fujita, Toshiro
TI Aldosterone and glomerular podocyte injury
SO CLINICAL AND EXPERIMENTAL NEPHROLOGY
LA English
DT Review
DE proteinuria; chronic kidney disease; metabolic syndrome; oxidative
   stress; salt; mineralocorticoid receptor activation; aldosterone
   releasing factors
ID CHRONIC KIDNEY-DISEASE; BODY-MASS INDEX; ANGIOTENSIN-CONVERTING ENZYME;
   ACTIVATED PROTEIN-KINASE; METABOLIC SYNDROME; PLASMA-ALDOSTERONE; NADPH
   OXIDASE; MINERALOCORTICOID RECEPTOR; NATRIURETIC PEPTIDE;
   CELL-PROLIFERATION
AB Aldosterone is traditionally viewed as a hormone regulating electrolyte and blood pressure homeostasis by acting on the distal nephron. Accumulating evidence suggests that aldosterone also plays pathogenetic roles in cardiovascular and renal injury. For example, aldosterone is a potent inducer of proteinuria. We demonstrated that podocyte injury underlies the pathogenesis of proteinuria in aldosterone-infused rats on a high salt diet. Mineralocorticoid receptor was detected in the podocytes in vivo and in vitro, and aldosterone caused induction of its effector kinase Sgk1, activation of NADPH oxidase and generation of reactive oxygen species. Selective aldosterone blocker eplerenone, as well as antioxidant tempol, ameliorated aldosterone-induced podocyte injury and proteinuria. Aldosterone was also involved in the podocyte damage and proteinuria of metabolic syndrome model SHR/NDmcr-cp. Adipocyte-derived aldosterone releasing factors were suggested to contribute to the aldosterone excess of this model. Furthermore, high salt diet markedly worsened the renal injury of SHR/NDmcr-cp. Although salt lowered serum aldosterone levels, it caused MR activation in the kidney. Accordingly, eplerenone dramatically improved the salt-evoked nephropathy. Taken together, aldosterone blockers can be an excellent therapeutic strategy for the treatment of podocyte injury, proteinuria, and cardiovascular and renal complications, not only in high aldosterone states but also in patients with activated MR signaling in the target tissue, whose circulating aldosterone level is not necessarily high. Addition of aldosterone blockers in patients treated with ACEIs or ARBs are also promising, because of "aldosterone breakthrough'' phenomenon. Careful monitoring of hyperkalemia is necessary, especially in patients with impaired renal function.
C1 [Nagase, Miki; Fujita, Toshiro] Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Bunkyo Ku, Tokyo 1138655, Japan.
C3 University of Tokyo
RP Nagase, M (corresponding author), Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM mnagase-tky@umin.ac.jp
CR Adelman RD, 2002, CURR OPIN NEPHROL HY, V11, P331, DOI 10.1097/00041552-200205000-00010
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Artune F, 2006, J MOL MED, V84, P737, DOI 10.1007/s00109-006-0082-0
   Berger S, 1998, P NATL ACAD SCI USA, V95, P9424, DOI 10.1073/pnas.95.16.9424
   Blasi ER, 2003, KIDNEY INT, V63, P1791, DOI 10.1046/j.1523-1755.2003.00929.x
   Bochud M, 2006, HYPERTENSION, V48, P239, DOI 10.1161/01.HYP.0000231338.41548.fc
   Boute N, 2000, NAT GENET, V24, P349, DOI 10.1038/74166
   Brown NJ, 2005, CURR OPIN NEPHROL HY, V14, P235, DOI 10.1097/01.mnh.0000165889.60254.98
   Chen HM, 2006, AM J KIDNEY DIS, V48, P772, DOI 10.1053/j.ajkd.2006.07.025
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Chrysostomou A, 2001, NEW ENGL J MED, V345, P925, DOI 10.1056/NEJM200109203451215
   de Paula RB, 2004, HYPERTENSION, V43, P41, DOI 10.1161/01.HYP.0000105624.68174.00
   Durvasula RV, 2004, KIDNEY INT, V65, P30, DOI 10.1111/j.1523-1755.2004.00362.x
   Ehrhart-Bornstein M, 2003, P NATL ACAD SCI USA, V100, P14211, DOI 10.1073/pnas.2336140100
   Eknoyan G, 2002, AM J KIDNEY DIS, V39, pS14, DOI 10.1053/ajkd.2002.30939
   Engeli S, 2005, HYPERTENSION, V45, P356, DOI 10.1161/01.HYP.0000154361.47683.d3
   Epstein M, 2001, J HYPERTENS, V19, P829, DOI 10.1097/00004872-200105000-00001
   Epstein M, 2006, AM J MED, V119, P912, DOI 10.1016/j.amjmed.2006.03.038
   Farjah M, 2003, HYPERTENSION, V41, P874, DOI 10.1161/01.HYP.0000063885.48344.EA
   Flier JS, 2004, CELL, V116, P337, DOI 10.1016/S0092-8674(03)01081-X
   Fox CS, 2004, JAMA-J AM MED ASSOC, V291, P844, DOI 10.1001/jama.291.7.844
   Fuller PJ, 2005, HYPERTENSION, V46, P1227, DOI 10.1161/01.HYP.0000193502.77417.17
   Gelber RP, 2005, AM J KIDNEY DIS, V46, P871, DOI 10.1053/j.ajkd.2005.08.015
   Goodfriend TL, 2004, HYPERTENSION, V43, P518, DOI 10.1161/01.HYP.0000116223.97436.e5
   Goodfriend TL, 2004, HYPERTENSION, V43, P358, DOI 10.1161/01.HYP.0000113294.06704.64
   Greene EL, 1996, J CLIN INVEST, V98, P1063, DOI 10.1172/JCI118867
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Han SY, 2006, J AM SOC NEPHROL, V17, P1362, DOI 10.1681/ASN.2005111196
   HENE RJ, 1982, KIDNEY INT, V21, P98, DOI 10.1038/ki.1982.14
   Henegar JR, 2001, J AM SOC NEPHROL, V12, P1211, DOI 10.1681/ASN.V1261211
   Hino M, 2005, BIOCHEM BIOPH RES CO, V330, P178, DOI 10.1016/j.bbrc.2005.02.142
   Hostetter TH, 2003, J AM SOC NEPHROL, V14, P2395, DOI 10.1097/01.ASN.0000086472.65806.73
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Hou JH, 2002, J AM SOC NEPHROL, V13, P1190, DOI 10.1097/01.ASN.0000013702.73570.3B
   Hsu CY, 2006, ANN INTERN MED, V144, P21, DOI 10.7326/0003-4819-144-1-200601030-00006
   Huber TB, 1998, J AM SOC NEPHROL, V9, P335
   Hummler E, 1997, P NATL ACAD SCI USA, V94, P11710, DOI 10.1073/pnas.94.21.11710
   Ibrahim HN, 2003, CURR OPIN NEPHROL HY, V12, P159, DOI 10.1097/00041552-200303000-00006
   Iseki K, 2004, KIDNEY INT, V65, P1870, DOI 10.1111/j.1523-1755.2004.00582.x
   Ishizawa K, 2005, HYPERTENSION, V46, P1046, DOI 10.1161/01.HYP.0000172622.51973.f5
   Kaplan JM, 2000, NAT GENET, V24, P251, DOI 10.1038/73456
   Keidar S, 2004, CIRCULATION, V109, P2213, DOI 10.1161/01.CIR.0000127949.05756.9D
   Kestila M, 1998, MOL CELL, V1, P575, DOI 10.1016/S1097-2765(00)80057-X
   Kitiyakara C, 2003, J AM SOC NEPHROL, V14, P2775, DOI 10.1097/01.ASN.0000092145.90389.65
   Knepper MA, 2003, ANN NY ACAD SCI, V986, P562, DOI 10.1111/j.1749-6632.2003.tb07254.x
   KRETZLER M, 1994, VIRCHOWS ARCH, V425, P181
   Kurella M, 2005, J AM SOC NEPHROL, V16, P2134, DOI 10.1681/ASN.2005010106
   Lang F, 2006, PHYSIOL REV, V86, P1151, DOI 10.1152/physrev.00050.2005
   Leopold JA, 2007, NAT MED, V13, P189, DOI 10.1038/nm1545
   LEWIS EJ, 1993, NEW ENGL J MED, V329, P1456, DOI 10.1056/NEJM199311113292004
   Lewko B, 2004, KIDNEY INT, V66, P1001, DOI 10.1111/j.1523-1755.2004.00848.x
   Lifton RP, 2001, CELL, V104, P545, DOI 10.1016/S0092-8674(01)00241-0
   Mann CC, 2005, SCIENCE, V307, P1716, DOI 10.1126/science.307.5716.1716
   Meneton P, 2004, AM J PHYSIOL-RENAL, V287, pF593, DOI 10.1152/ajprenal.00454.2003
   Miyata K, 2005, J AM SOC NEPHROL, V16, P2906, DOI 10.1681/ASN.2005040390
   Mundel P, 1997, EXP CELL RES, V236, P248, DOI 10.1006/excr.1997.3739
   Nagai Y, 2005, HYPERTENSION, V46, P1039, DOI 10.1161/01.HYP.0000174593.88899.68
   Nagase M, 1997, HYPERTENSION, V30, P177, DOI 10.1161/01.HYP.30.2.177
   Nagase M, 2007, HYPERTENSION, V50, P877, DOI 10.1161/HYPERTENSIONAHA.107.091058
   Nagase M, 2006, J AM SOC NEPHROL, V17, P3438, DOI 10.1681/ASN.2006080944
   Nagase M, 2006, HYPERTENSION, V47, P1084, DOI 10.1161/01.HYP.0000222003.28517.99
   Ninomiya T, 2006, AM J KIDNEY DIS, V48, P383, DOI 10.1053/j.ajkd.2006.06.003
   Nishiyama A, 2005, HYPERTENSION, V45, P710, DOI 10.1161/01.HYP.0000154681.38944.9a
   Nishiyama A, 2004, HYPERTENSION, V43, P841, DOI 10.1161/01.HYP.0000118519.66430.22
   Ortmann J, 2004, HYPERTENSION, V44, P974, DOI 10.1161/01.HYP.0000149249.09147.b4
   Pagtalunan ME, 1997, J CLIN INVEST, V99, P342, DOI 10.1172/JCI119163
   Pavenstädt H, 2003, PHYSIOL REV, V83, P253, DOI 10.1152/physrev.00020.2002
   Pitt B, 2003, NEW ENGL J MED, V348, P1309, DOI 10.1056/NEJMoa030207
   Pitt B, 1999, NEW ENGL J MED, V341, P709, DOI 10.1056/NEJM199909023411001
   PRadervand S, 1999, P NATL ACAD SCI USA, V96, P1732, DOI 10.1073/pnas.96.4.1732
   Praga M, 2006, CURR OPIN NEPHROL HY, V15, P481, DOI 10.1097/01.mnh.0000242172.06459.7c
   Quinkler M, 2005, CIRCULATION, V112, P1435, DOI 10.1161/CIRCULATIONAHA.105.539122
   Reiser J, 2004, J AM SOC NEPHROL, V15, P2246, DOI 10.1097/01.ASN.0000136312.46464.33
   Ribstein J, 2005, J AM SOC NEPHROL, V16, P1320, DOI 10.1681/ASN.2004100878
   Ring AM, 2007, P NATL ACAD SCI USA, V104, P4025, DOI 10.1073/pnas.0611728104
   Ritz E, 2006, BLOOD PURIFICAT, V24, P63, DOI 10.1159/000089439
   Rocha R, 2002, ANN NY ACAD SCI, V970, P89, DOI 10.1111/j.1749-6632.2002.tb04415.x
   Rocha R, 1999, HYPERTENSION, V33, P232, DOI 10.1161/01.HYP.33.1.232
   Rocha R, 2002, AM J PHYSIOL-HEART C, V283, pH1802, DOI 10.1152/ajpheart.01096.2001
   Ronzaud C, 2007, J AM SOC NEPHROL, V18, P1679, DOI 10.1681/ASN.2006090975
   Rossi GP, 2006, HYPERTENSION, V48, P232, DOI 10.1161/01.HYP.0000230444.01215.6a
   Rozansky DJ, 2006, SEMIN NEPHROL, V26, P173, DOI 10.1016/j.semnephrol.2005.09.008
   Ruano M, 2005, OBES SURG, V15, P670, DOI 10.1381/0960892053923734
   Sato A, 2003, HYPERTENSION, V41, P64, DOI 10.1161/01.HYP.0000044937.95080.E9
   Schjoedt KJ, 2006, KIDNEY INT, V70, P536, DOI 10.1038/sj.ki.5001580
   Sharma M, 1998, AM J PHYSIOL-RENAL, V274, pF623
   Shibata S, 2007, HYPERTENSION, V49, P355, DOI 10.1161/01.HYP.0000255636.11931.a2
   Shih NY, 1999, SCIENCE, V286, P312, DOI 10.1126/science.286.5438.312
   Shimomura I, 1996, NAT MED, V2, P800, DOI 10.1038/nm0796-800
   SIMPSON SA, 1953, EXPERIENTIA, V9, P333, DOI 10.1007/BF02155834
   Stocco DM, 2005, MOL ENDOCRINOL, V19, P2647, DOI 10.1210/me.2004-0532
   Sun GP, 2006, J AM SOC NEPHROL, V17, P2193, DOI 10.1681/ASN.2005121375
   Sun Y, 2002, AM J PATHOL, V161, P1773, DOI 10.1016/S0002-9440(10)64454-9
   Takaya K, 1996, NAT GENET, V14, P130, DOI 10.1038/ng1096-130
   Tanaka H, 2006, KIDNEY INT, V69, P369, DOI 10.1038/sj.ki.5000050
   Terada Y, 2005, J AM SOC NEPHROL, V16, P2296, DOI 10.1681/ASN.2005020129
   Tryggvason K, 2006, NEW ENGL J MED, V354, P1387, DOI 10.1056/NEJMra052131
   TUCK ML, 1981, NEW ENGL J MED, V304, P930, DOI 10.1056/NEJM198104163041602
   Vallon V, 2005, AM J PHYSIOL-REG I, V289, pR395, DOI 10.1152/ajpregu.00731.2004
   Verhave JC, 2004, J INTERN MED, V256, P324, DOI 10.1111/j.1365-2796.2004.01390.x
   Wehling M, 1997, ANNU REV PHYSIOL, V59, P365, DOI 10.1146/annurev.physiol.59.1.365
   WEISINGE.JR, 1974, ANN INTERN MED, V81, P440, DOI 10.7326/0003-4819-81-4-440
   White WB, 2003, HYPERTENSION, V41, P1021, DOI 10.1161/01.HYP.0000067463.13172.EA
   Williams G, 2005, HEART FAIL REV, V10, P7, DOI 10.1007/s10741-005-2343-3
   Williams GH, 2004, AM J CARDIOL, V93, P990, DOI 10.1016/j.amjcard.2004.01.007
   Williams JS, 2003, J CLIN ENDOCR METAB, V88, P2364, DOI 10.1210/jc.2003-030490
   Wilson FH, 2001, SCIENCE, V293, P1107, DOI 10.1126/science.1062844
   Wolf G, 2005, DIABETES, V54, P1626, DOI 10.2337/diabetes.54.6.1626
   Wulff P, 2002, J CLIN INVEST, V110, P1263, DOI 10.1172/JCI200215696
   YAOITA E, 1990, AM J PATHOL, V136, P899
NR 110
TC 63
Z9 67
U1 1
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1342-1751
EI 1437-7799
J9 CLIN EXP NEPHROL
JI Clin. Exp. Nephrol.
PD AUG
PY 2008
VL 12
IS 4
BP 233
EP 242
DI 10.1007/s10157-008-0034-9
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 343IN
UT WOS:000258846900001
PM 18317876
DA 2025-06-11
ER

PT J
AU Aradhyula, V
   Waigi, E
   Bearss, NR
   Edwards, JM
   Joe, B
   McCarthy, CG
   Koch, LB
   Wenceslau, CF
AF Aradhyula, Vaishnavi
   Waigi, Emily
   Bearss, Nicole R.
   Edwards, Jonnelle M.
   Joe, Bina
   McCarthy, Cameron G.
   Koch, Lauren B.
   Wenceslau, Camilla F.
TI Intrinsic exercise capacity induces divergent vascular plasticity via
   arachidonic acid-mediated inflammatory pathways in female rats
SO VASCULAR PHARMACOLOGY
LA English
DT Article
DE Test
ID ENDOTHELIAL DYSFUNCTION; HYPERPOLARIZING FACTOR; OXIDATIVE STRESS;
   AEROBIC CAPACITY; SMALL ARTERIES; LIPOXIN
AB Metabolic syndrome prevalence has increased among US adults, particularly among non-hispanic white and black women. Sedentary behavior often leads to chronic inflammation, a triggering factor of metabolic syndrome. Given that intrinsic exercise capacity is genetically inherited, we questioned if low-grade chronic inflammation would be present in a female rat model of low intrinsic exercise capacity-induced metabolic syndrome, while beneficial increase of resolution of inflammation would be present in a female rat model of high intrinsic exercise capacity. In the vascular system, two primary markers for inflammation and resolution of inflammation are cyclooxygenase (COX) and lipoxygenase (LOX), respectively. Our study focused on the novel hypothesis that untrained, inherited exercise capacity induces divergent vascular plasticity via changes in the delicate balance between COX and LOX inflammatory mediators. We used divergent rat strains with low (LCR) and high (HCR) aerobic running capacity. By using animals with contrasting intrinsic exercise capacities, it is possible to determine the exact triggers that lead to inherited vascular plasticity in female rats. We observed that female LCR displayed increased periovarian fat pad and body weight, which is congruent with their obesity-presenting phenotype. Furthermore, LCR presented with vascular hypocontractility and increased COX and LOX-derived pro-inflammatory factors. On the other hand, HCR presented with a "shutdown" of COX-induced vasoconstriction and enhanced resolution of inflammation to maintain vascular tone and homeostasis. In conclusion, LCR display low-grade chronic inflammation via increased COX activity. These results provide mechanistic clues as to why lower intrinsic aerobic capacity correlates with a predisposition to risk of vascular disease. Conversely, being born with higher intrinsic aerobic capacity is a significant factor for improved vascular physiology in female rats.
C1 [Aradhyula, Vaishnavi; Waigi, Emily; Bearss, Nicole R.; Edwards, Jonnelle M.; Joe, Bina; McCarthy, Cameron G.; Koch, Lauren B.; Wenceslau, Camilla F.] Univ Toledo, Dept Physiol & Pharmacol, Coll Med & Life Sci, 2801 W Bancroft St, Toledo, OH 43606 USA.
C3 University System of Ohio; University of Toledo
RP Wenceslau, CF (corresponding author), Univ Toledo, Dept Physiol & Pharmacol, Coll Med & Life Sci, Lab Vasc Biol LVB, 3000 Transverse Dr, Toledo, OH 43614 USA.
EM Camilla.Wenceslau@utoledo.edu
FU National Institutes of Health [R01HL149762, R00GM118885, K99HL151889,
   R01HL1430820]; American Heart Association [18POST34060003]; NSF
   [AGEP1432878]; Office of Research Infrastructure Programs [P40OD021331];
   Department of Physiology & Pharmacology, University of Toledo College of
   Medicine, Toledo, OH; National Heart Lung and Blood Institute
   [K99HL151889] Funding Source: NIH RePORTER; National Institute of
   General Medical Sciences [R00GM118885] Funding Source: NIH RePORTER
FX This work was supported by National Institutes of Health (R01HL149762
   and R00GM118885 to C.F.W., K99HL151889 to C.G.M., R01HL1430820 to B.J.),
   American Heart Association (18POST34060003 to C.G.M.) and NSF
   (AGEP1432878 to J.M.E.). The LCR and HCR rat model system was funded by
   the Office of Research Infrastructure Programs grant (P40OD021331 to
   L.G.K.). The rat models for low and high exercise capacity are
   maintained as an international resource with support from the Department
   of Physiology & Pharmacology, University of Toledo College of Medicine,
   Toledo, OH. Contact LGKLauren.Koch2@UToledo.Edu for information on the
   rat models.
CR [Anonymous], 2018, WHO REPORT GLOBAL AC
   Bäck M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0104593
   Battault S, 2018, AM J PHYSIOL-HEART C, V314, pH497, DOI 10.1152/ajpheart.00217.2017
   Bishop-Bailey D, 2006, ARTERIOSCL THROM VAS, V26, P956, DOI 10.1161/01.ATV.0000219672.68024.bc
   BOONEN HCM, 1993, J CARDIOVASC PHARM, V22, P388, DOI 10.1097/00005344-199309000-00007
   Bouchard C, 1998, MED SCI SPORT EXER, V30, P252, DOI 10.1097/00005768-199802000-00013
   Boyle JJ, 2003, ARTERIOSCL THROM VAS, V23, P1553, DOI 10.1161/01.ATV.0000086961.44581.B7
   Campbell WB, 2010, PFLUG ARCH EUR J PHY, V459, P881, DOI 10.1007/s00424-010-0804-6
   Chiang N, 2005, PROSTAG LEUKOTR ESS, V73, P163, DOI 10.1016/j.plefa.2005.05.003
   Craft Baine B, 2014, Int J Lib Arts Soc Sci, V2, P65
   Davel AP, 2018, J AM HEART ASSOC, V7, DOI 10.1161/JAHA.117.007675
   de Chantemele EJB, 2012, J MOL CELL CARDIOL, V52, P840, DOI 10.1016/j.yjmcc.2011.08.018
   Division of Nutrition, 2019, PHYS ACTIVITY OBESIT
   Edwards JM, 2020, CURR PHARM DESIGN, V26, P3723, DOI 10.2174/1381612826666200417150121
   Fernandes T, 2011, BRAZ J MED BIOL RES, V44, P836, DOI 10.1590/S0100-879X2011007500112
   Fleming I, 2004, PHARMACOL RES, V49, P525, DOI 10.1016/j.phrs.2003.11.016
   Hagdorn QAJ, 2019, AM J PHYSIOL-HEART C, V316, pH1552, DOI 10.1152/ajpheart.00182.2019
   Hilgers RHP, 2012, AM J PHYSIOL-HEART C, V303, pH513, DOI 10.1152/ajpheart.01175.2011
   HWA JJ, 1994, AM J PHYSIOL, V266, pH952, DOI 10.1152/ajpheart.1994.266.3.H952
   Koch LG, 2011, CIRC RES, V109, P1162, DOI 10.1161/CIRCRESAHA.111.253807
   Koch LG, 2005, INTEGR COMP BIOL, V45, P405, DOI 10.1093/icb/45.3.405
   Laufs U, 2005, ARTERIOSCL THROM VAS, V25, P809, DOI 10.1161/01.ATV.0000158311.24443.af
   Luksha L, 2009, ATHEROSCLEROSIS, V202, P330, DOI 10.1016/j.atherosclerosis.2008.06.008
   Maddipati KR, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.580117
   Moore JX, 2017, PREV CHRONIC DIS, V14, DOI 10.5888/pcd14.160287
   Mulvany MJ, 2008, MED BIOL ENG COMPUT, V46, P461, DOI 10.1007/s11517-008-0305-3
   Nosova EV, 2014, J SURG RES, V190, P672, DOI 10.1016/j.jss.2014.02.001
   Novak CM, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005869
   Pober JS, 2015, CSH PERSPECT BIOL, V7, DOI 10.1101/cshperspect.a016345
   Pourageaud F, 1997, AM J PHYSIOL-HEART C, V273, pH1699, DOI 10.1152/ajpheart.1997.273.4.H1699
   Reusch JEB, 2018, ENDOCRINOLOGY, V159, P9, DOI 10.1210/en.2017-03019
   Romanko OP, 2005, AM J PHYSIOL-HEART C, V289, pH2097, DOI 10.1152/ajpheart.00213.2005
   Romero R, 1996, PROSTAG LEUKOTR ESS, V54, P187, DOI 10.1016/S0952-3278(96)90015-0
   Roy S., FUNCTION, V2
   Scotland RS, 2005, CIRCULATION, V111, P796, DOI 10.1161/01.CIR.0000155238.70797.4E
   Serhan CN, 2014, NATURE, V510, P92, DOI 10.1038/nature13479
   Silva JF, 2016, FRONT PHYSIOL, V7, DOI 10.3389/fphys.2016.00386
   Singh NK, 2019, PROG LIPID RES, V73, P28, DOI 10.1016/j.plipres.2018.11.001
   Stapleton Phoebe A, 2008, Pathophysiology, V15, P79, DOI 10.1016/j.pathophys.2008.04.007
   Stenholm S, 2008, CURR OPIN CLIN NUTR, V11, P693, DOI 10.1097/MCO.0b013e328312c37d
   Tang EHC, 2009, PHARMACOL THERAPEUT, V122, P140, DOI 10.1016/j.pharmthera.2009.02.006
   Troiano RP, 2008, MED SCI SPORT EXER, V40, P181, DOI 10.1249/mss.0b013e31815a51b3
   Vessières E, 2013, VASC PHARMACOL, V58, P356, DOI 10.1016/j.vph.2013.03.001
   Wenceslau CF, 2019, PHARMACOL RES, V141, P276, DOI 10.1016/j.phrs.2019.01.015
   Wenceslau CF, 2014, J VASC RES, V51, P407, DOI 10.1159/000371490
   Wenceslau CF, 2014, J HYPERTENS, V32, P542, DOI 10.1097/HJH.0000000000000059
   Young DR, 2016, CIRCULATION, V134, pE262, DOI 10.1161/CIR.0000000000000440
   Zhu SS, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0221366
NR 48
TC 1
Z9 2
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1537-1891
EI 1879-3649
J9 VASC PHARMACOL
JI Vasc. Pharmacol.
PD OCT
PY 2021
VL 140
AR 106862
DI 10.1016/j.vph.2021.106862
EA SEP 2021
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA WK0GC
UT WOS:000709412300005
PM 33872803
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Chou, CL
   Li, CH
   Lin, H
   Liao, MH
   Wu, CC
   Chen, JS
   Sue, YM
   Fang, TC
AF Chou, Chu-Lin
   Li, Ching-Hao
   Lin, Heng
   Liao, Mei-Hui
   Wu, Chin-Chen
   Chen, Jin-Shuen
   Sue, Yuh-Mou
   Fang, Te-Chao
TI Role of activating transcription factor 3 in fructose-induced metabolic
   syndrome in mice
SO HYPERTENSION RESEARCH
LA English
DT Article; Proceedings Paper
CT Annual Meeting and Conference of the Taiwan-Society-of-Internal-Medicine
CY DEC 02-03, 2017
CL Taipei, TAIWAN
SP Taiwan Soc Internal Med
ID HYPERINSULINEMIA-INDUCED HYPERTENSION; INSULIN-RESISTANCE; FED RATS;
   VASCULAR DYSFUNCTION; LIPID HOMEOSTASIS; OXIDATIVE STRESS; ATF3;
   EXPRESSION; DIET; STEATOSIS
AB Activating transcription factor 3 (ATF3) has been implicated in cardiovascular disease and inflammation. This study examined the effects of ATF3 knockout (KO) on blood pressure, glucose intolerance, dyslipidemia, inflammation, and visceral adiposity in mice fed who did and did not consume a high-fructose diet. Male mice were divided into four groups (N = 15 for each group): the Con (control) group (wild-type mice fed a standard chow diet), Fru group (wild-type mice fed a high-fructose [60% fructose] diet), ATF3KO-Con group (ATF3 KO mice fed a standard chow diet), and ATF3KO-Fru group (ATF3 KO mice fed a high-fructose [60% fructose] diet). Experiments were conducted for 8 weeks. Our data demonstrated that ATF3 KO mice have lower systolic blood pressure (SBP) levels than do wild-type mice, and that high-fructose diets increase SBP levels in both wild-type and ATF3 KO mice. ATF3 KO in mice increased the serum levels of glucose, insulin, triglycerides, tumor necrosis factor-alpha, and intercellular adhesion molecule-1, impaired endothelium-dependent aortic relaxation, increased aorta wall thickness and lipid peroxide, and expanded visceral adiposity. These symptoms resembled those exhibited by the wild-type mice fed a high-fructose diet, which caused hyperglycemia, insulin resistance, dyslipidemia, endothelium-dependent aortic dysfunction, inflammation, aorta remodeling, and visceral adiposity. A high-fructose diet among ATF3 KO mice deteriorated metabolic parameters and inflammatory cytokines. The present results therefore suggest that ATF3 deficiency is involved in the pathogenesis of metabolic syndrome and ATF3 might have a therapeutic role in fructose-induced impairment of endothelium-dependent aortic relaxation, a rising of inflammatory cytokines, and metabolic syndrome.
C1 [Chou, Chu-Lin; Chen, Jin-Shuen] Natl Def Med Ctr, Div Nephrol, Dept Internal Med, Triserv Gen Hosp, Taipei, Taiwan.
   [Li, Ching-Hao; Lin, Heng] Taipei Med Univ, Sch Med, Dept Physiol, Coll Med, Taipei, Taiwan.
   [Li, Ching-Hao] Taipei Med Univ, Grad Inst Med Sci, Coll Med, Taipei, Taiwan.
   [Lin, Heng] Taipei Med Univ, Coll Pharm, Taipei, Taiwan.
   [Liao, Mei-Hui; Wu, Chin-Chen] Natl Def Med Ctr, Grad Inst Med Sci, Taipei, Taiwan.
   [Sue, Yuh-Mou] Taipei Med Univ, Wan Fang Hosp, Div Nephrol, Dept Internal Med, Taipei, Taiwan.
   [Sue, Yuh-Mou; Fang, Te-Chao] Taipei Med Univ, Sch Med, Div Nephrol, Dept Internal Med, Taipei, Taiwan.
   [Fang, Te-Chao] Taipei Med Univ, Taipei Med Univ Hosp, Div Nephrol, Dept Internal Med, Taipei, Taiwan.
C3 Tri-Service General Hospital; National Defense Medical Center; Taipei
   Medical University; Taipei Medical University; Taipei Medical
   University; National Defense Medical Center; Taipei Medical University;
   Taipei Municipal WanFang Hospital; Taipei Medical University; Taipei
   Medical University Hospital; Taipei Medical University
RP Sue, YM (corresponding author), Taipei Med Univ, Wan Fang Hosp, Div Nephrol, Dept Internal Med, Taipei, Taiwan.; Sue, YM; Fang, TC (corresponding author), Taipei Med Univ, Sch Med, Div Nephrol, Dept Internal Med, Taipei, Taiwan.; Fang, TC (corresponding author), Taipei Med Univ, Taipei Med Univ Hosp, Div Nephrol, Dept Internal Med, Taipei, Taiwan.
EM sueym@tmu.edu.tw; fangtechao@gmail.com
RI CHEN, JUI-YI/AAV-8854-2021; Liu, Chun-Yu/I-4358-2015
OI Chou, Chu-Lin/0000-0002-9695-1067
FU Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan [105
   TMU-WFH-06]; Taipei Medical University [TMU103-AE1-B30]; Ministry of
   Science and Technology, Taiwan [MOST 105-2314-B-038-024]
FX This work was supported by Wan Fang Hospital, Taipei Medical University,
   Taipei, Taiwan (105 TMU-WFH-06; funds for Y-MS), by Taipei Medical
   University (TMU103-AE1-B30; funds for T-CF) and by Ministry of Science
   and Technology, Taiwan (MOST 105-2314-B-038-024; funds for T-CF). The
   funder had no role in study design, data collection and analysis,
   publication decision, or manuscript preparation.
CR Azmi MB, 2016, PAK J PHARM SCI, V29, P1619
   Catena C, 2003, KIDNEY INT, V64, P2163, DOI 10.1046/j.1523-1755.2003.00313.x
   Choi Y, 2017, FOOD CHEM TOXICOL, V103, P111, DOI 10.1016/j.fct.2017.02.039
   Chou CL, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0119843
   Chou CL, 2013, HYPERTENS RES, V36, P123, DOI 10.1038/hr.2012.124
   Chou CL, 2011, ARCH MED SCI, V7, P882, DOI 10.5114/aoms.2011.25566
   Fang TC, 1998, HYPERTENSION, V32, P235, DOI 10.1161/01.HYP.32.2.235
   Fang TC, 1998, J HYPERTENS, V16, P1767, DOI 10.1097/00004872-199816120-00009
   Farah V, 2006, AUTON NEUROSCI-BASIC, V130, P41, DOI 10.1016/j.autneu.2006.05.006
   Hai T, 1999, GENE EXPRESSION, V7, P321
   HAI TW, 1989, GENE DEV, V3, P2083, DOI 10.1101/gad.3.12b.2083
   HALLFRISCH J, 1990, FASEB J, V4, P2652, DOI 10.1096/fasebj.4.9.2189777
   Hartman MG, 2004, MOL CELL BIOL, V24, P5721, DOI 10.1128/MCB.24.13.5721-5732.2004
   HWANG IS, 1987, HYPERTENSION, V10, P512, DOI 10.1161/01.HYP.10.5.512
   Kalfon R, 2017, CARDIOVASC RES, V113, P134, DOI 10.1093/cvr/cvw228
   Lamounier-Zepter V, 2006, BEST PRACT RES CL EN, V20, P355, DOI 10.1016/j.beem.2006.07.002
   Lee RMKW, 2017, HYPERTENS RES, V40, P311, DOI 10.1038/hr.2016.145
   Lin H, 2014, MOL PHARMACOL, V85, P682, DOI 10.1124/mol.113.090092
   Liu YF, 2016, J BIOL CHEM, V291, P21771, DOI 10.1074/jbc.M116.726364
   Miatello R, 2005, AM J HYPERTENS, V18, P864, DOI 10.1016/j.amjhyper.2004.12.012
   Miatello R, 2002, AM J HYPERTENS, V15, P872, DOI 10.1016/S0895-7061(02)02983-7
   Nyby MD, 2007, HYPERTENS RES, V30, P451, DOI 10.1291/hypres.30.451
   Priyadarshini E, 2017, CAN J DIABETES, V41, P41, DOI 10.1016/j.jcjd.2016.06.003
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Rynes J, 2012, MOL CELL BIOL, V32, P3949, DOI 10.1128/MCB.00429-12
   Shinozaki K, 2004, HYPERTENSION, V43, P255, DOI 10.1161/01.HYP.0000111136.86976.26
   Teasdale JE, 2017, SCI REP-UK, V7, DOI 10.1038/srep39945
   Thompson MR, 2009, J MOL MED, V87, P1053, DOI 10.1007/s00109-009-0520-x
   Zhou YX, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/925631
   Zmuda EJ, 2010, MOL ENDOCRINOL, V24, P1423, DOI 10.1210/me.2009-0463
NR 30
TC 12
Z9 13
U1 0
U2 5
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD AUG
PY 2018
VL 41
IS 8
BP 589
EP 597
DI 10.1038/s41440-018-0058-9
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology
GA GP3ZS
UT WOS:000440795800007
PM 29895822
DA 2025-06-11
ER

PT J
AU Francisqueti, FV
   Minatel, IO
   Ferron, AJT
   Bazan, SGZ
   Silva, VD
   Garcia, JL
   de Campos, DHS
   Ferreira, AL
   Moreto, F
   Cicogna, AC
   Corrêa, CR
AF Francisqueti, Fabiane Valentini
   Minatel, Igor Otavio
   Togneri Ferron, Artur Junio
   Zanati Bazan, Silmeia Garcia
   Silva, Vanessa dos Santos
   Garcia, Jessica Leite
   Salome de Campos, Dijon Henrique
   Ferreira, Ana Lucia
   Moreto, Fernando
   Cicogna, Antonio Carlos
   Correa, Camila Renata
TI Effect of Gamma-Oryzanol as Therapeutic Agent to Prevent Cardiorenal
   Metabolic Syndrome in Animals Submitted to High Sugar-Fat Diet
SO NUTRIENTS
LA English
DT Article
DE high sugar-fat diet; obesity; cardiac dysfunction; renal disease;
   gamma-oryzanol; Cardiorenal Metabolic Syndrome
ID RICE BRAN OIL; INSULIN-RESISTANCE; OXIDATIVE STRESS; KIDNEY INJURY;
   OBESITY; COMPONENTS; DYSLIPIDEMIA; HYPERTENSION; GLUCOSE; MODEL
AB Background: The high consumption of fat and sugar contributes to the development of obesity and co-morbidities, such as diabetes, and cardiovascular and kidney diseases. Different strategies have been used to prevent these diseases associated with obesity, such as changes in eating habits and/or the addition of dietary components with anti-inflammatory and anti-oxidant properties, such as gamma-oryzanol (Oz) present mainly in bran layers and rice germ. Methods: Animals were randomly divided into four experimental groups and fed ad libitum for 20 weeks with control diet (C, n = 8), control diet + Oz (C + Oz, n = 8), high-sugar and high-fat diet (HSF, n = 8), and high-sugar and high-fat diet + Oz (HSF + Oz, n = 8). HSF groups also received water + sucrose (25%). The dose of Oz was added to diets to reach 0.5% of final concentration (w/w). Evaluation in animals included food and caloric intake, body weight, plasma glucose, insulin, triglycerides, uric acid, HOMA-IR, glomerular filtration rate, protein/creatinine ratio, systolic blood pressure, and Doppler echocardiographic. Results: Animals that consumed the HSF diet had weight gain compared to group C, increased insulin, HOMA, glucose and triglycerides, there were also atrial and ventricular structural alterations, deterioration of systolic and diastolic function, decreased glomerular filtration rate, and proteinuria. Gamma-oryzanol is significantly protective against effects on body weight, hypertriglyceridemia, renal damage, and against structural and functional alteration of the heart. Conclusion: Gamma-oryzanol shows potential as a therapeutic to prevent Cardiorenal Metabolic Syndrome.
C1 [Francisqueti, Fabiane Valentini; Togneri Ferron, Artur Junio; Zanati Bazan, Silmeia Garcia; Silva, Vanessa dos Santos; Garcia, Jessica Leite; Salome de Campos, Dijon Henrique; Ferreira, Ana Lucia; Moreto, Fernando; Cicogna, Antonio Carlos; Correa, Camila Renata] Sao Paulo State Univ Unesp, Sch Med, BR-18618687 Botucatu, SP, Brazil.
   [Minatel, Igor Otavio] Sao Paulo State Univ Unesp, Inst Biosci, BR-18618689 Botucatu, SP, Brazil.
C3 Universidade Estadual Paulista; Universidade Estadual Paulista
RP Corrêa, CR (corresponding author), Sao Paulo State Univ Unesp, Sch Med, BR-18618687 Botucatu, SP, Brazil.
EM fabiane_vf@yahoo.com.br; igorminatel@hotmail.com;
   artur.ferron@gmail.com; sgzanati@fmb.unesp.br; vangynera@gmail.com;
   jessleitegarcia@gmail.com; dijoncampos@gmail.com; ferreira@fmb.unesp.br;
   fer_moreto@yahoo.com.br; cicogna@fmb.unesp.br; ccorrea@fmb.unesp.br
RI Silva, Vanessa/JXX-4985-2024; Correa, Camila/Q-2071-2019; Zanati-Bazan,
   Silmeia/F-3177-2012; Minatel, Igor/A-9094-2016; Francisqueti,
   Fabiane/AAY-8977-2020; Moreto, Fernando/I-7690-2013; Leite Garcia,
   Jessica/Q-8779-2018; Ferron, Artur Junio/M-5194-2017; Francisqueti-
   Ferron, Fabiane/M-4919-2017
OI Moreto, Fernando/0000-0002-4028-0014; Correa, Camila
   Renata/0000-0001-8493-5329; Leite Garcia, Jessica/0000-0002-3670-243X;
   Ferron, Artur Junio/0000-0001-7089-3033; Francisqueti- Ferron,
   Fabiane/0000-0003-2910-4308; Zanati Bazan, Silmeia
   Garcia/0000-0002-0607-8189; Cicogna, Antonio Carlos/0000-0002-4402-6523
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo-FAPESP
   [2015/10626-0]
FX This work was funded by Fundacao de Amparo a Pesquisa do Estado de Sao
   Paulo-FAPESP (2015/10626-0).
CR Anna V. Olah, 2010, Orvosi Hetilap, V151, P864, DOI 10.1556/OH.2010.28891
   Blüher M, 2016, CLIN SCI, V130, P1603, DOI 10.1042/CS20160005
   BOLTONSMITH C, 1994, INT J OBESITY, V18, P820
   Cabandugama PK, 2017, MED CLIN N AM, V101, P129, DOI 10.1016/j.mcna.2016.08.009
   Candiracci M, 2014, NUTRITION, V30, P466, DOI 10.1016/j.nut.2013.09.016
   Canella D. S., 2015, SAUDE PUBLICA, V31, P2331, DOI [10.1590/0102-311X0018421426840813, DOI 10.1590/0102-311X0018421426840813]
   Devarajan S, 2016, J CLIN LIPIDOL, V10, P339, DOI 10.1016/j.jacl.2015.12.011
   Di Lullo L, 2017, INT J CARDIOL, V227, P143, DOI 10.1016/j.ijcard.2016.11.156
   Dikow R, 2010, AM J NEPHROL, V32, P13, DOI 10.1159/000313846
   dos Santos PP, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0098895
   Fukushima A, 2016, BBA-MOL CELL BIOL L, V1861, P1525, DOI 10.1016/j.bbalip.2016.03.020
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gilmore TD, 2006, ONCOGENE, V25, P6680, DOI 10.1038/sj.onc.1209954
   Hayes A, 2016, OBESITY, V24, P1752, DOI 10.1002/oby.21544
   IBGEInstituto Brasileiro de Geografia e Estatistica Pesquisa de Orcamentos Familiares (POF), 2008, AN CONS AL PESS BRAS
   Islam MS, 2008, BRIT J PHARMACOL, V154, P812, DOI 10.1038/bjp.2008.137
   Justo ML, 2013, EUR J NUTR, V52, P789, DOI 10.1007/s00394-012-0385-6
   Khan M. A. H., 2014, DRUGS THER, V28, P313, DOI [10.1007/s10557-014-6530-024842561, DOI 10.1007/S10557-014-6530-024842561]
   Kovesdy C., 2017, J NEPHROL, V27, P85
   la Fleur SE, 2011, INT J OBESITY, V35, P595, DOI 10.1038/ijo.2010.164
   Lechi A., 2017, BULIM OBES, V22, P43, DOI [10.1007/s40519-016-0330-427812911, DOI 10.1007/S40519-016-0330-427812911]
   LEVIN RJ, 1994, AM J CLIN NUTR, V59, p690S, DOI 10.1093/ajcn/59.3.690S
   Linz D, 2015, AM J HYPERTENS, V28, P256, DOI 10.1093/ajh/hpu123
   Marsh SA, 2007, AM J PHYSIOL-HEART C, V293, pH292, DOI 10.1152/ajpheart.01362.2006
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Minatel IO, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17081107
   Minatel IO, 2016, J MED FOOD, V19, P710, DOI 10.1089/jmf.2015.3647
   Minatel IO, 2014, J MED FOOD, V17, P1134, DOI 10.1089/jmf.2014.3146
   Noiri E., 2006, EXP NEPHROL, V104, pe6, DOI [10.1159/00009325816707910, DOI 10.1159/00009325816707910]
   Oliveira Junior S. A., 2013, DIABETOLOGIA, V12, P65, DOI [10.1186/1475-2840-12-6523587409, DOI 10.1186/1475-2840-12-6523587409]
   Panchal SK, 2011, J CARDIOVASC PHARM, V57, P51, DOI [10.1097/FJC.0b013e3181feb90a, 10.1097/FJC.0b013e31821b1379]
   Perry C. L., 2015, INT J BEHAV NUTR PHY, P12, DOI [10.1186/1479-5868-12-S1-S126222489, DOI 10.1186/1479-5868-12-S1-S126222489]
   Rao YPC, 2016, BIOCHEM BIOPH RES CO, V479, P747, DOI 10.1016/j.bbrc.2016.09.140
   Rodríguez-Monforte M, 2017, EUR J NUTR, V56, P925, DOI 10.1007/s00394-016-1305-y
   Ruan XZ, 2009, NAT REV NEPHROL, V5, P713, DOI 10.1038/nrneph.2009.184
   Son MJ, 2011, J FOOD SCI, V76, pH7, DOI 10.1111/j.1750-3841.2010.01907.x
   Sowers J. R., 2011, CARDIORENAL MED, V15, P12, DOI [10.1159/00032282222258461, DOI 10.1159/00032282222258461]
   Stanhope KL, 2008, CURR OPIN LIPIDOL, V19, P16, DOI 10.1097/MOL.0b013e3282f2b24a
   Swinburn BA, 2004, PUBLIC HEALTH NUTR, V7, P123, DOI 10.1079/PHN2003585
   Szymanski M. K., 2012, ANIMAL MODELS CARDIO, V17, P411, DOI [10.1007/s10741-011-9279-621909828, DOI 10.1007/S10741-011-9279-621909828]
   van Dokkum RPE, 2004, J AM SOC NEPHROL, V15, P3103, DOI 10.1097/01.ASN.0000145895.62896.98
   Wang O, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0118135
   Windt W. A. K. M., 2008, DIAL TRANSP, V23, P3103, DOI [10.1093/ndt/gfn23318503101, DOI 10.1093/NDT/GFN23318503101]
   Xu ZM, 1999, J AGR FOOD CHEM, V47, P2724, DOI 10.1021/jf981175j
   Xu ZM, 2001, J AGR FOOD CHEM, V49, P2077, DOI 10.1021/jf0012852
   Yang P, 2017, J LIPID RES, V58, P1417, DOI 10.1194/jlr.M076216
   Zolali E, 2015, IRAN J BASIC MED SCI, V18, P1257
NR 47
TC 45
Z9 47
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2017
VL 9
IS 12
AR 1299
DI 10.3390/nu9121299
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FR6PQ
UT WOS:000419188600025
PM 29186059
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Quesada-López, T
   González-Dávalos, L
   Piña, E
   Mora, O
AF Quesada-Lopez, Tania
   Gonzalez-Davalos, Laura
   Pina, Enrique
   Mora, Ofelia
TI HSD1 and AQP7 short-term gene regulation by cortisone in 3T3-L1
   adipocytes
SO ADIPOCYTE
LA English
DT Article
DE 3T3-L1 cells; Aqp7; cortisone; Hsd1; metabolic syndrome
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; VISCERAL ADIPOSE-TISSUE;
   METABOLIC SYNDROME; AQUAPORIN ADIPOSE; CENTRAL OBESITY; EXPRESSION;
   GLUCOCORTICOIDS; STRESS; TRANSPORT; DEXAMETHASONE
AB Adipose Tissue (AT) is a complex organ with a crucial regulatory role in energy metabolism and in the development of obesity and the Metabolic Syndrome (MS). Modified responses and the metabolism of hormones have been observed in visceral adiposity during obesity, specifically as related with cortisone. The objective of this study was to assess, in the 3T3-L1 adipocyte cell line, the short-term effect of cortisone on the expression of 11-Hydroxysteroid dehydrogenase 1 (Hsd1), which is responsible for activation of cortisone into cortisol, and for Aquaporin 7 (Aqp7), involved in glycerol transport through the cell membrane. Total RNA (tRNA) and complementary DNA (cDNA) were obtained from cell samples treated with cortisone (0.1, 1, and 10M) during different times (0, 5, 10, 15, and 20min, and 48h) to quantify the expression of the aforementioned genes by real time PCR employing MnSOD and Ppia as housekeeping genes. There was a time-dependent response of Aqp7, a dose-dependent response of Hsd1, and an increase observed in the expression of both genes during min 1 of treatment (5- and 6-fold, respectively), followed by a decrease during the following 5-10min (P < 0.05). With the 1-M cortisone treatment, both genes showed cubic tendencies in their expression; the Hsd1 tendency is described by the equation y = 0.18x(3)-1.65x(2)+3.59x+1.31, while the Aqp7 tendency is described by y = 0.33x(3)-2.67x(2)+4.93x+1.84. There are immediate and quantitatively important actions of cortisone on the expression of Aqp7 and Hsd1 in 3T3-L1 adipocytes.
C1 [Quesada-Lopez, Tania] Univ Autonoma Queretaro, Fac Ciencias Nat, Nutr, Juriquilla, Mexico.
   [Gonzalez-Davalos, Laura; Mora, Ofelia] UNAM, FES Cuautitlan, Lab Rumiol & Metab Nutr RuMeN, Secretaria Posgrad, Blvd Juriquilla 3001, Juriquilla 76230, Queretaro, Mexico.
   [Pina, Enrique] UNAM, Fac Med, Dept Bioquim, Juriquilla, Queretaro, Mexico.
C3 Universidad Autonoma de Queretaro; Universidad Nacional Autonoma de
   Mexico; Universidad Nacional Autonoma de Mexico
RP Mora, O (corresponding author), UNAM, FES Cuautitlan, Lab Rumiol & Metab Nutr RuMeN, Secretaria Posgrad, Blvd Juriquilla 3001, Juriquilla 76230, Queretaro, Mexico.
EM ofemora66@unam.mx
RI Quesada Lopez, Tania Paloma/L-6690-2018
OI Quesada Lopez, Tania Paloma/0000-0002-7818-4351; Mora,
   Ofelia/0000-0002-7073-7740; Pina, Enrique/0000-0003-2436-9956
FU CONACYT (Mexico); PAPIIT-UNAM [IN218112]
FX T. Quesada thanks CONACYT (Mexico) for a scholarship at FESC-UNAM. The
   authors received a research grant from PAPIIT-UNAM (IN218112).
CR Balachandran A, 2008, ENDOCRINOLOGY, V149, P4069, DOI 10.1210/en.2008-0088
   BJORNTORP P, 1991, DIABETES CARE, V14, P1132, DOI 10.2337/diacare.14.12.1132
   Bujalska IJ, 1997, LANCET, V349, P1210, DOI 10.1016/S0140-6736(96)11222-8
   Chapman K, 2013, PHYSIOL REV, V93, P1139, DOI 10.1152/physrev.00020.2012
   Chen JA, 2015, EXP THER MED, V10, P1967, DOI 10.3892/etm.2015.2771
   Chen MG, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00310
   Fasshauer M, 2003, HORM METAB RES, V35, P222
   Franchini A, 2004, HISTOL HISTOPATHOL, V19, P693, DOI 10.14670/HH-19.693
   Haimovich G, 2013, CELL, V153, P1000, DOI 10.1016/j.cell.2013.05.012
   Haimovich G, 2013, BBA-GENE REGUL MECH, V1829, P643, DOI 10.1016/j.bbagrm.2013.01.004
   Hajduch E, 2001, FEBS LETT, V492, P199, DOI 10.1016/S0014-5793(01)02242-6
   Hara-Chikuma M, 2005, J BIOL CHEM, V280, P15493, DOI 10.1074/jbc.C500028200
   Hibuse T, 2005, P NATL ACAD SCI USA, V102, P10993, DOI 10.1073/pnas.0503291102
   Kishida K, 2000, J BIOL CHEM, V275, P20896, DOI 10.1074/jbc.M001119200
   Kotelevtsev Y, 1997, P NATL ACAD SCI USA, V94, P14924, DOI 10.1073/pnas.94.26.14924
   Lee MJ, 2014, BBA-MOL BASIS DIS, V1842, P473, DOI 10.1016/j.bbadis.2013.05.029
   Lee MJ, 2013, MOL ASPECTS MED, V34, P1, DOI 10.1016/j.mam.2012.10.001
   Lucau-Danila A, 2005, MOL CELL BIOL, V25, P1860, DOI 10.1128/MCB.25.5.1860-1868.2005
   Maeda N, 2004, P NATL ACAD SCI USA, V101, P17801, DOI 10.1073/pnas.0406230101
   Masuzaki H, 2001, SCIENCE, V294, P2166, DOI 10.1126/science.1066285
   Miranda M, 2010, J CLIN ENDOCR METAB, V95, P3470, DOI 10.1210/jc.2009-2655
   Miyauchi T, 2015, FEBS LETT, V589, P608, DOI 10.1016/j.febslet.2015.01.025
   Nevoux J, 2015, PFLUG ARCH EUR J PHY, V467, P1931, DOI 10.1007/s00424-014-1629-5
   Nicholson AC, 2007, BRIT J PHARMACOL, V151, P807, DOI 10.1038/sj.bjp.0707250
   Peckett AJ, 2011, METABOLISM, V60, P1500, DOI 10.1016/j.metabol.2011.06.012
   Posas F, 2000, J BIOL CHEM, V275, P17249, DOI 10.1074/jbc.M910016199
   Shen FX, 2012, EXP CELL RES, V318, P2377, DOI 10.1016/j.yexcr.2012.07.016
   SHORTMAN K, 1985, CELL IMMUNOL, V93, P350, DOI 10.1016/0008-8749(85)90140-6
   Staab CA, 2010, J STEROID BIOCHEM, V119, P56, DOI 10.1016/j.jsbmb.2009.12.013
   Stewart PM, 1996, CLIN ENDOCRINOL, V44, P493, DOI 10.1046/j.1365-2265.1996.716535.x
   Stoenoiu MS, 2003, J AM SOC NEPHROL, V14, P555, DOI 10.1097/01.ASN.0000053420.37216.9E
   Tchernof A, 2013, PHYSIOL REV, V93, P359, DOI 10.1152/physrev.00033.2011
   Tonon L, 2010, NUCLEIC ACIDS RES, V38, pW286, DOI 10.1093/nar/gkq473
   Voice MW, 1996, BIOCHEM J, V317, P621, DOI 10.1042/bj3170621
   Wajchenberg BL, 2000, ENDOCR REV, V21, P697, DOI 10.1210/er.21.6.697
   Walker BR, 2006, DIABETIC MED, V23, P1281, DOI 10.1111/j.1464-5491.2006.01998.x
   Xu C, 2009, MOL ENDOCRINOL, V23, P1161, DOI 10.1210/me.2008-0464
NR 37
TC 4
Z9 4
U1 0
U2 3
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 2162-3945
EI 2162-397X
J9 ADIPOCYTE
JI Adipocyte
PY 2016
VL 5
IS 3
BP 298
EP 305
DI 10.1080/21623945.2016.1187341
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DV9HA
UT WOS:000383250100005
PM 27617175
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Damirchi, A
   Tehrani, BS
   Alamdari, KA
   Babaei, P
AF Damirchi, Arsalan
   Tehrani, Bahram Soltani
   Alamdari, Karim Azali
   Babaei, Parvin
TI Influence of Aerobic Training and Detraining on Serum BDNF, Insulin
   Resistance, and Metabolic Risk Factors in Middle-Aged Men Diagnosed With
   Metabolic Syndrome
SO CLINICAL JOURNAL OF SPORT MEDICINE
LA English
DT Article
DE aerobic training and detraining; BDNF; metabolic syndrome
ID OXIDATIVE STRESS MARKERS; NEUROTROPHIC FACTOR BDNF; POSTMENOPAUSAL
   WOMEN; PHYSICAL-ACTIVITY; REDUCTION INTERVENTION; POSTPRANDIAL LIPEMIA;
   DEFINED EXERCISE; RAT-BRAIN; OBESITY; LIPOPROTEINS
AB Objective: To study the influence of aerobic exercise training on brain-derived neurotrophic factor (BDNF), insulin resistance, and lipid profile in middle-aged men diagnosed with metabolic syndrome (MetS).
   Design: This is an experimental repeated measure study.
   Setting: Subjects participated in aerobic training programs (18 sessions of 25-40 minutes per session) in Guilan University gymnasium and court.
   Participants: A total of 21 middle-aged men (50-65 years old) diagnosed with MetS participated.
   Interventions: We randomly divided 21 middle-aged men with MetS into exercise and control groups. The exercise group followed an aerobic training program (18 sessions, 3/wk) at 50% to 60% of (V) over dotO(2) peak (25-40 minutes per session) and 6 weeks of detraining. Blood samples were collected at baseline, end of the training, and detraining.
   Main Outcome Measures: High BDNF level in patients with MetS and its reduction after chronic aerobic exercise.
   Results: Aerobic training significantly decreased all the metabolic risk factors, including overall MetS z score, insulin resistance, and lipid profile (P < 0.05). After the detraining period, plasma triglyceride, high-density lipoprotein, and also overall MetS z score remained unchanged (P < 0.05); however, serum BDNF, which was decreased by aerobic training (P = 0.013), restored to the baseline at the end of the detraining (P = 0.018).
   Conclusions: Improved metabolic risk factors along with decreased serum BDNF in response to aerobic training and the opposite direction during the detraining emphasize the importance of physical activity in the treatment of MetS and prevention of related diseases.
C1 [Damirchi, Arsalan] Univ Guilan, Fac Phys Educ & Sport Sci, Dept Sport Physiol, Rasht, Iran.
   [Tehrani, Bahram Soltani; Babaei, Parvin] Guilan Univ Med Sci, Cellular & Mol Res Ctr, Rasht, Iran.
   [Alamdari, Karim Azali] Azarbaijan Shahid Madani Univ, Fac Psychol & Educ, Dept Phys Educ & Sport Sci, Tabriz, Iran.
   [Babaei, Parvin] Guilan Univ Med Sci, Dept Physiol, Rasht, Iran.
C3 University of Guilan; Guilan University of Medical Sciences; Azarbaijan
   Shahid Madani University; Guilan University of Medical Sciences
RP Babaei, P (corresponding author), Guilan Univ Med Sci, Fac Med, Dept Physiol, Cellular & Mol Res Ctr, POB 3363, Rasht, Iran.
EM p_babaei@gums.ac.ir
RI Alamdari, Karim/IYS-3087-2023; babaei, parvin/ABB-8760-2021; Tehrani,
   Bahram/S-9078-2017; Damirchi, Arsalan/HPD-7498-2023; babaei,
   parvin/H-5269-2017
OI soltani tehrani, bahram/0000-0003-2685-8606; azali alamdari,
   karim/0000-0002-6134-1912; damirchi, arsalan/0000-0002-3442-0631;
   babaei, parvin/0000-0003-4870-8182
FU Research Council of the University of Guilan
FX Supported by grants from the Research Council of the University of
   Guilan.
CR [Anonymous], JAMA
   Bateman LA, 2011, AM J CARDIOL, V108, P838, DOI 10.1016/j.amjcard.2011.04.037
   Chaldakov GN, 2011, ARCH ITAL BIOL, V149, P257, DOI 10.4449/aib.v149i2.1366
   Cotman CW, 2002, TRENDS NEUROSCI, V25, P295, DOI 10.1016/S0166-2236(02)02143-4
   Egan MF, 2003, CELL, V112, P257, DOI 10.1016/S0092-8674(03)00035-7
   Fox EA, 2004, AM J PHYSIOL-REG I, V286, pR994, DOI 10.1152/ajpregu.00727.2003
   Frank LL, 2005, OBES RES, V13, P615, DOI 10.1038/oby.2005.66
   Friedenreich CM, 2011, ENDOCR-RELAT CANCER, V18, P357, DOI 10.1530/ERC-10-0303
   Fujimura H, 2002, THROMB HAEMOSTASIS, V87, P728
   Geroldi D, 2006, MED HYPOTHESES, V67, P195, DOI 10.1016/j.mehy.2006.02.001
   Gill JMR, 2003, J CLIN ENDOCR METAB, V88, P4328, DOI 10.1210/jc.2003-030226
   Goekint M, 2010, NEUROSCI LETT, V486, P146, DOI 10.1016/j.neulet.2010.09.032
   Golden E, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010099
   Hardman AE, 1998, J APPL PHYSIOL, V84, P1895, DOI 10.1152/jappl.1998.84.6.1895
   Herd SL, 1998, BRIT J NUTR, V80, P57, DOI 10.1017/S0007114598001779
   Hristova MG, 2011, EURASIAN J MED, V43, P141, DOI 10.5152/eajm.2011.32
   Johnson JL, 2007, AM J CARDIOL, V100, P1759, DOI 10.1016/j.amjcard.2007.07.027
   Karolkiewicz J, 2009, ARCH GERONTOL GERIAT, V49, pE67, DOI 10.1016/j.archger.2008.09.001
   Katzmarzyk PT, 2003, MED SCI SPORT EXER, V35, P1703, DOI 10.1249/01.MSS.0000089337.73244.9B
   Knaepen K, 2010, SPORTS MED, V40, P765, DOI 10.2165/11534530-000000000-00000
   Krabbe KS, 2007, DIABETOLOGIA, V50, P431, DOI 10.1007/s00125-006-0537-4
   Lakka TA, 2007, APPL PHYSIOL NUTR ME, V32, P76, DOI 10.1139/h06-113
   Lebrun B, 2006, AUTON NEUROSCI-BASIC, V126, P30, DOI 10.1016/j.autneu.2006.02.027
   Lu B, 2005, NAT REV NEUROSCI, V6, P603, DOI 10.1038/nrn1726
   MANKOWITZ K, 1992, ATHEROSCLEROSIS, V95, P181, DOI 10.1016/0021-9150(92)90021-8
   Marques-Aleixo I, 2012, PROG NEUROBIOL, V99, P149, DOI 10.1016/j.pneurobio.2012.08.002
   Masharani U., 2011, Greenspans Basic Clinical Endocrinology, V9th ed., P605
   Mitsuhashi Toshitake, 2011, Tokai J Exp Clin Med, V36, P95
   MOTOYAMA M, 1995, EUR J APPL PHYSIOL, V70, P126, DOI 10.1007/BF00361539
   Newman A., 2009, OJIN, P14
   Nofuji Y, 2008, NEUROSCI LETT, V437, P29, DOI 10.1016/j.neulet.2008.03.057
   Nonomura T, 2001, Int J Exp Diabetes Res, V2, P201, DOI 10.1155/EDR.2001.201
   Okura T, 2012, OBESITY SILVER SPRIN, V15, P2478
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   PELLEYMOUNTER MA, 1995, EXP NEUROL, V131, P229, DOI 10.1016/0014-4886(95)90045-4
   Petibois C, 2004, J CLIN ENDOCR METAB, V89, P3377, DOI 10.1210/jc.2003-031311
   Radák Z, 2001, NEUROCHEM INT, V38, P17, DOI 10.1016/S0197-0186(00)00063-2
   Radak Z, 2006, NEUROCHEM INT, V49, P387, DOI 10.1016/j.neuint.2006.02.004
   Raffaelli F, 2009, OBESITY, V17, P1375, DOI 10.1038/oby.2008.654
   Rasmussen P, 2009, EXP PHYSIOL, V94, P1062, DOI 10.1113/expphysiol.2009.048512
   Ratel S, 2012, APPL PHYSIOL NUTR ME, V37, P72, DOI [10.1139/H11-130, 10.1139/h11-130]
   Ross R, 2004, OBES RES, V12, P789, DOI 10.1038/oby.2004.95
   Schiffer T, 2009, HORM METAB RES, V41, P250, DOI 10.1055/s-0028-1093322
   Seidah NG, 1996, FEBS LETT, V379, P247, DOI 10.1016/0014-5793(95)01520-5
   Seifert T, 2010, AM J PHYSIOL-REG I, V298, pR372, DOI 10.1152/ajpregu.00525.2009
   Slentz CA, 2007, J APPL PHYSIOL, V103, P432, DOI 10.1152/japplphysiol.01314.2006
   Suwa M, 2006, METABOLISM, V55, P852, DOI 10.1016/j.metabol.2006.02.012
   Tang SW, 2008, NEUROSCI LETT, V431, P62, DOI 10.1016/j.neulet.2007.11.019
   Wallace TM, 2002, DIABETIC MED, V19, P527, DOI 10.1046/j.1464-5491.2002.00745.x
   Williams PT, 2006, OBESITY, V14, P1975, DOI 10.1038/oby.2006.231
   Zoladz JA, 2008, J PHYSIOL PHARMACOL, V59, P119
NR 51
TC 39
Z9 40
U1 0
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1050-642X
EI 1536-3724
J9 CLIN J SPORT MED
JI Clin. J. Sport Med.
PD NOV
PY 2014
VL 24
IS 6
BP 513
EP 518
PG 6
WC Orthopedics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Physiology; Sport Sciences
GA AT2AM
UT WOS:000344733000016
PM 24662570
DA 2025-06-11
ER

PT J
AU Ghazizadeh, H
   Khorasani, MY
   Shabani, N
   Sahranavard, T
   Zare-Feyzabadi, R
   Mohammadi-Bajgiran, M
   Timar, A
   Oladi, MR
   Moazedi, S
   Mosalman-Zadeh, N
   Khedmatgozar, H
   Rohban, M
   Hasanzadeh, E
   Javandoost, A
   Nazarpour, S
   Bahrami, A
   Ferns, GA
   Haghdoost, AA
   Esmaily, H
   Ghayour-Mobarhan, M
AF Ghazizadeh, Hamideh
   Khorasani, Mahdiyeh Yaghooti
   Shabani, Niloofar
   Sahranavard, Toktam
   Zare-Feyzabadi, Reza
   Mohammadi-Bajgiran, Maryam
   Timar, Ameneh
   Oladi, Mohammad Reza
   Moazedi, Sara
   Mosalman-Zadeh, Negin
   Khedmatgozar, Hamed
   Rohban, Mohadeseh
   Hasanzadeh, Elahe
   Javandoost, Ali
   Nazarpour, Shahin
   Bahrami, Afsane
   Ferns, Gordon A.
   Haghdoost, Ali Akbar
   Esmaily, Habibollah
   Ghayour-Mobarhan, Majid
TI Relationship Between Clinical, Demographic and Socioeconomic Factors
   with Suicide Ideation; A Cross-sectional Study
SO COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
LA English
DT Article
DE Suicide ideation; clinical parameters; demographic factors;
   socio-economic factors; MCHC; FBG
ID PHYSICAL-ACTIVITY; METABOLIC SYNDROME; IRON-METABOLISM; CYTOKINE LEVELS;
   RISK-FACTORS; ASSOCIATION; DEPRESSION; BEHAVIOR; SMOKING; BLOOD
AB Background: Suicide has grown in global prevalence as a public health problem. We aimed to evaluate the association of socioeconomic factors, biochemical and hematologic tests, and suicide ideation. Methods: In this cross-sectional study, 8267 Iranian adults aged 35 - 65 years old were enrolled. The assessment of suicide ideation was made by the completion of Beck's depression inventory (BDI) questionnaire; according to one specific item on the questionnaire: "have you ever decided to suicide in the past week?" Results: According to our results, 6.9% of subjects had ideation of suicide. The results showed high levels of FBG, RBC, MCHC, and hs-CRP were associated with suicide ideation. Obese, single subjects, and current-smokers had a higher risk of suicide ideation. Conclusion: Increased physical activity, obesity, and smoking are associated with a high risk of suicide ideation; whilst, a high MCHC is related to a low risk of suicide ideation in Iranian adults.
C1 [Ghazizadeh, Hamideh] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Razavi Khorasan, Iran.
   [Ghazizadeh, Hamideh; Zare-Feyzabadi, Reza; Mohammadi-Bajgiran, Maryam; Timar, Ameneh; Oladi, Mohammad Reza; Khedmatgozar, Hamed; Rohban, Mohadeseh; Hasanzadeh, Elahe; Javandoost, Ali; Nazarpour, Shahin; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Int UNESCO Ctr Hlth Related Basic Sci & Human Nut, Mashhad, Razavi Khorasan, Iran.
   [Khorasani, Mahdiyeh Yaghooti; Shabani, Niloofar; Sahranavard, Toktam; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Moazedi, Sara; Mosalman-Zadeh, Negin] Varastegan Inst Med Sci, Dept Nutr Sci, Mashhad, Razavi Khorasan, Iran.
   [Khedmatgozar, Hamed] Texas Tech Univ, Ctr Biotechnol & Genom, Lubbock, TX 79409 USA.
   [Bahrami, Afsane] Mashhad Univ Med Sci, Imam Reza Hosp, Clin Res Dev Unit, Fac Med, Mashhad, Razavi Khorasan, Iran.
   [Bahrami, Afsane] Mashhad Univ Med Sci, Akbar Hosp, Fac Med, Clin Res Dev Unit, Mashhad, Razavi Khorasan, Iran.
   [Ferns, Gordon A.] Brighton & Sussex Med Sch, Div Med Educ, Brighton, Sussex, England.
   [Haghdoost, Ali Akbar] Kerman Univ Med Sci, Modeling Hlth Res Ctr, Kerman, Iran.
   [Esmaily, Habibollah] Mashhad Univ Med Sci, Social Determinants Hlth Res Ctr, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Texas Tech University
   System; Texas Tech University; Mashhad University of Medical Sciences;
   Mashhad University of Medical Sciences; University of Sussex; University
   of Brighton; Kerman University of Medical Sciences; Mashhad University
   of Medical Sciences
RP Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Int UNESCO Ctr Hlth Related Basic Sci & Human Nut, Mashhad, Razavi Khorasan, Iran.; Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Razavi Khorasan, Iran.; Esmaily, H (corresponding author), Mashhad Univ Med Sci, Social Determinants Hlth Res Ctr, Mashhad, Razavi Khorasan, Iran.
EM esmaily@mums.ac.ir; ghayourm@mums.ac.ir
RI Ghayour-Mobarhan, Majid/AAY-5963-2020; Sahranavard,
   Toktam/AGK-9166-2022; Hasanzadeh, Elahe/AAL-4486-2021; Ghazizadeh,
   Hamideh/ABE-8941-2020; bahrami, afsaneh/Q-3369-2018; Haghdoost,
   Ali/C-2823-2009
OI Hasanzadeh, Elahe/0000-0002-4764-9638; Yaghooti Khorasani,
   Mahdiyeh/0000-0001-5110-0851; Sahranavard, Toktam/0000-0001-6446-7783;
   Bahrami, Afsane/0000-0002-4563-6112
FU Mashhad University of Medical Sciences, Mashhad, Iran [85134]
FX Research reported in this publication was supported by the Mashhad
   University of Medical Sciences, Mashhad, Iran (85134)
CR Alothman D, 2020, J AFFECT DISORDERS, V260, P67, DOI 10.1016/j.jad.2019.08.093
   Amiri S, 2018, J AFFECT DISORDERS, V238, P615, DOI 10.1016/j.jad.2018.05.028
   [Anonymous], 2011, DIABETES RES CLIN PR, V93, P299, DOI 10.1016/j.diabres.2011.03.012
   Asadi Z, 2020, J CLIN LAB ANAL, V34, DOI 10.1002/jcla.23523
   Asadi Z, 2020, IUBMB LIFE, V72, P706, DOI 10.1002/iub.2172
   Baek JH, 2014, PROG NEURO-PSYCHOPH, V51, P113, DOI 10.1016/j.pnpbp.2014.01.018
   Batty GD, 2012, J EPIDEMIOL COMMUN H, V66, P650, DOI 10.1136/jech-2011-200464
   Baune BT, 2006, INT PSYCHOGERIATR, V18, P437, DOI 10.1017/S1041610205002759
   Borges G, 2010, J CLIN PSYCHIAT, V71, P1617, DOI 10.4088/JCP.08m04967blu
   Breslau N, 2005, ARCH GEN PSYCHIAT, V62, P328, DOI 10.1001/archpsyc.62.3.328
   Brown DR, 2002, MED SCI SPORT EXER, V34, P1087, DOI 10.1097/00005768-200207000-00006
   Calderon-Vilca H.D., 2017, 36 INT C CHILEAN COM, P1
   Courtet P, 2015, EUR NEUROPSYCHOPHARM, V25, P1824, DOI 10.1016/j.euroneuro.2015.05.003
   Dutton GR, 2013, INT J OBESITY, V37, P1282, DOI 10.1038/ijo.2012.224
   Ebrahimi Hossein, 2014, J Caring Sci, V3, P131, DOI 10.5681/jcs.2014.014
   Esteghamati A, 2008, DIABETES RES CLIN PR, V82, P104, DOI 10.1016/j.diabres.2008.07.009
   Ghassemzadeh H, 2005, DEPRESS ANXIETY, V21, P185, DOI 10.1002/da.20070
   Ghazizadeh H., 2020, OBES MED, V19, DOI [10.1016/j.obmed.2020.100277, DOI 10.1016/J.OBMED.2020.100277]
   Ghazizadeh H, 2020, SLEEP HEALTH, V6, P684, DOI 10.1016/j.sleh.2020.03.007
   Ghazizadeh H, 2020, BMC PSYCHIATRY, V20, DOI 10.1186/s12888-020-02663-4
   Ghazizadeh H, 2020, ARCH MED RES, V51, P261, DOI 10.1016/j.arcmed.2020.02.006
   Ghazizadeh H, 2020, J CLIN LAB ANAL, V34, DOI 10.1002/jcla.23160
   Gibbs HM, 2016, J PSYCHIATR RES, V79, P28, DOI 10.1016/j.jpsychires.2016.04.002
   Guenther PM, 2013, J ACAD NUTR DIET, V113, P569, DOI 10.1016/j.jand.2012.12.016
   Haghparast-Bidgoli H, 2018, INT J EQUITY HEALTH, V17, DOI 10.1186/s12939-018-0794-0
   Hassanian-Moghaddam Hossein, 2017, Iran J Psychiatry, V12, P73
   Hedayatnia M, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-01204-y
   Heo YS, 2015, IND HEALTH, V53, P542, DOI 10.2486/indhealth.2015-0021
   Hughes JR, 2008, DRUG ALCOHOL DEPEN, V98, P169, DOI 10.1016/j.drugalcdep.2008.06.003
   Igwe MN, 2013, AFR HEALTH SCI, V13, P68, DOI 10.4314/ahs.v13i1.10
   Janelidze S, 2011, BRAIN BEHAV IMMUN, V25, P335, DOI 10.1016/j.bbi.2010.10.010
   Kim AM, 2020, PSYCHIAT RES, V284, DOI 10.1016/j.psychres.2020.112745
   Kim DK, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2015-010183
   Kim SY, 2011, CRISIS, V32, P5, DOI 10.1027/0227-5910/a000046
   Kivimaki M, 2009, DIABETES CARE, V32, P1867, DOI 10.2337/dc09-0716
   Kocic SS, 2008, VOJNOSANIT PREGL, V65, P371, DOI 10.2298/VSP0805371K
   Koponen H, 2015, BMC PSYCHIATRY, V15, DOI 10.1186/s12888-015-0567-x
   Maes M, 2014, EXPERT OPIN THER TAR, V18, P495, DOI 10.1517/14728222.2014.888417
   Mancia G, 2007, EUR HEART J, V28, P1462, DOI 10.1093/eurheartj/ehm236
   McGirr A, 2008, PSYCHOL MED, V38, P407, DOI 10.1017/S0033291707001419
   Nock MK, 2009, PLOS MED, V6, DOI 10.1371/journal.pmed.1000123
   Nordentoft M, 2019, SCIENCE, V365, P725, DOI 10.1126/science.aaz1568
   Orum Mehmet Hamdi, 2018, J Immunoassay Immunochem, V39, P647, DOI 10.1080/15321819.2018.1529682
   Paperwalla KN, 2004, MED CLIN N AM, V88, P1483, DOI 10.1016/j.mcna.2004.06.007
   Park RJ, 2017, EUR NEUROPSYCHOPHARM, V27, P885, DOI 10.1016/j.euroneuro.2017.06.010
   Parra-Uribe I, 2017, BMC PSYCHIATRY, V17, DOI 10.1186/s12888-017-1317-z
   Pompili Maurizio, 2006, Eat Behav, V7, P384, DOI 10.1016/j.eatbeh.2005.12.004
   Poorolajal J, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0156348
   Quan H, 2002, SOC PSYCH PSYCH EPID, V37, P190, DOI 10.1007/s001270200014
   Rabiee Behnam, 2017, Middle East J Dig Dis, V9, P86, DOI 10.15171/mejdd.2017.56
   Rezaeian A, 2014, SINGAP MED J, V55, P587, DOI 10.11622/smedj.2014156
   Rodelli M, 2018, PREV MED, V113, P32, DOI 10.1016/j.ypmed.2018.05.002
   Rybka J, 2013, FREE RADICAL BIO MED, V63, P187, DOI 10.1016/j.freeradbiomed.2013.05.019
   Song HB, 2016, J AFFECT DISORDERS, V197, P21, DOI 10.1016/j.jad.2016.02.035
   Sweileh WM, 2018, ANN GEN PSYCHIATR, V17, DOI 10.1186/s12991-018-0214-2
   Taliaferro LA, 2008, J SCHOOL HEALTH, V78, P545, DOI 10.1111/j.1746-1561.2008.00342.x
   Taliaferro LA, 2009, J AM COLL HEALTH, V57, P427, DOI 10.3200/JACH.57.4.427-436
   Tannenbaum Cara, 2009, Healthc Policy, V5, pe177
   Tayefi M, 2017, PSYCHONEUROENDOCRINO, V81, P63, DOI 10.1016/j.psyneuen.2017.02.035
   Torkanlou K, 2016, ANN NUTR METAB, V69, P232, DOI 10.1159/000454894
   Umegaki H, 2011, GERIATR GERONTOL INT, V11, P262, DOI 10.1111/j.1447-0594.2010.00672.x
   Vancampfort D, 2018, J AFFECT DISORDERS, V225, P438, DOI 10.1016/j.jad.2017.08.070
   Vishram JKK, 2014, DAN MED J, V61
   Wadden TA, 2007, GASTROENTEROLOGY, V132, P2226, DOI 10.1053/j.gastro.2007.03.051
   Walsh Susan M, 2002, Clin Podiatr Med Surg, V19, P493, DOI 10.1016/S0891-8422(02)00019-8
   Wang B, 2017, EUR J ENDOCRINOL, V177, pR169, DOI 10.1530/EJE-16-0952
   Weisenhorn DA, 2017, J CHILD FAM STUD, V26, P161, DOI 10.1007/s10826-016-0538-y
   Wipfli B, 2011, SCAND J MED SCI SPOR, V21, P474, DOI 10.1111/j.1600-0838.2009.01049.x
   Wysokinski A, 2018, PSYCHIAT DANUB, V30, P323, DOI 10.24869/psyd.2018.323
   Yaghooti-Khorasani M, 2020, DIAB MET SYND CLIN R, V14, P1689, DOI 10.1016/j.dsx.2020.08.031
   Zheng XY, 2016, EUR J SPORT SCI, V16, P818, DOI 10.1080/17461391.2015.1111938
NR 71
TC 2
Z9 2
U1 0
U2 2
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1386-2073
EI 1875-5402
J9 COMB CHEM HIGH T SCR
JI Comb. Chem. High Throughput Screen
PY 2022
VL 25
IS 6
BP 1047
EP 1057
DI 10.2174/1386207324666210302094438
PG 11
WC Biochemical Research Methods; Chemistry, Applied; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy
GA 3U1AP
UT WOS:000840702400008
PM 33653243
DA 2025-06-11
ER

PT J
AU Moriarity, DP
   Kautz, MM
   Giollabhui, NM
   Klugman, J
   Coe, CL
   Ellman, LM
   Abramson, LY
   Alloy, LB
AF Moriarity, Daniel P.
   Kautz, Marin M.
   Giollabhui, Naoise Mac
   Klugman, Joshua
   Coe, Christopher L.
   Ellman, Lauren M.
   Abramson, Lyn Y.
   Alloy, Lauren B.
TI Bidirectional Associations Between Inflammatory Biomarkers and
   Depressive Symptoms in Adolescents: Potential Causal Relationships
SO CLINICAL PSYCHOLOGICAL SCIENCE
LA English
DT Article
DE affective disorders; causal analysis; causality; depression; health
ID C-REACTIVE PROTEIN; CHILDRENS DEPRESSION; SOCIOECONOMIC-STATUS;
   METABOLIC SYNDROME; CYTOKINES; METAANALYSIS; CHILDHOOD; INVENTORY;
   SICKNESS; PSYCHOPATHOLOGY
AB There are inconsistent findings in the literature about the directionality and magnitude of the association between inflammation and depressive symptoms. This analysis separates predictors into between-persons and within-person components to gain greater clarity about this relationship. Blood samples were collected and depressive symptoms assessed in 140 adolescents (54% female, 59% Black; mean age = 16.1 years) with at least three blood draws and a total of 394 follow-up observations. Multilevel modeling indicated that the within-persons effect of tumor necrosis factor alpha predicted change in total depressive symptoms, which suggests a potential causal relationship. There were no significant within-persons effects of total depressive symptoms on change in biomarkers. Exploratory analyses examined associations between inflammatory biomarkers and subsets of depressive symptoms. These findings inform modeling decisions that may explain inconsistencies in the extant literature as well as suggest potential causal relationships between certain proteins with significant within-persons effects on depressive symptoms and vice-versa.
C1 [Moriarity, Daniel P.; Kautz, Marin M.; Giollabhui, Naoise Mac; Klugman, Joshua; Ellman, Lauren M.; Alloy, Lauren B.] Temple Univ, Dept Psychol, Weiss Hall,1701 N 13th St, Philadelphia, PA 19122 USA.
   [Coe, Christopher L.; Abramson, Lyn Y.] Univ Wisconsin, Dept Psychol, 1202 W Johnson St, Madison, WI 53706 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple
   University; University of Wisconsin System; University of Wisconsin
   Madison
RP Alloy, LB (corresponding author), Temple Univ, Dept Psychol, Weiss Hall,1701 N 13th St, Philadelphia, PA 19122 USA.
EM lalloye@temple.edu
RI Moriarity, Daniel/AAV-8535-2020; Mac Giollabhui, Naoise/J-4768-2019;
   Klugman, Joshua/H-8300-2013
OI P. Moriarity, Daniel/0000-0001-8678-7307; Mac Giollabhui,
   Naoise/0000-0003-4226-5704; Klugman, Joshua/0000-0002-7072-0041
FU National Institute of Mental Health [MH079369, MH101168]; National
   Institute of Mental Health Research Service Award [F31MH122116];
   National Science Foundation [2018263024]; National Institute of Mental
   Health Research Service [F31MH118808]
FX This research was supported by National Institute of Mental Health
   Grants MH079369 and MH101168 (to L. B. Alloy). D. P. Moriarity was
   supported by National Institute of Mental Health Research Service Award
   F31MH122116. M. M. Kautz was supported by National Science Foundation
   Graduate Research Fellowship 2018263024. N. Mac Giollabhui was supported
   by National Institute of Mental Health Research Service Award
   F31MH118808.
CR Acock A.C., 2014, GENTLE INTRO STATA, V4th
   Alloy LB, 2012, J CLIN CHILD ADOLESC, V41, P539, DOI 10.1080/15374416.2012.703123
   Balázs J, 2013, J CHILD PSYCHOL PSYC, V54, P670, DOI 10.1111/jcpp.12016
   Bang YR, 2015, PSYCHIAT INVEST, V12, P23, DOI 10.4306/pi.2015.12.1.23
   Bates D, 2015, J STAT SOFTW, V67, P1, DOI 10.18637/jss.v067.i01
   Bell JA, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/tp.2017.155
   Breen EC, 2011, CLIN VACCINE IMMUNOL, V18, P1229, DOI 10.1128/CVI.05032-11
   Brymer KJ, 2019, FRONT NEUROSCI-SWITZ, V13, DOI 10.3389/fnins.2019.00098
   Calder PC, 2006, AM J CLIN NUTR, V83, p1505S, DOI 10.1093/ajcn/83.6.1505S
   Copeland WE, 2012, BIOL PSYCHIAT, V71, P15, DOI 10.1016/j.biopsych.2011.09.023
   Dabitao D, 2011, J IMMUNOL METHODS, V372, P71, DOI 10.1016/j.jim.2011.06.033
   Dantzer R, 2008, NAT REV NEUROSCI, V9, P46, DOI 10.1038/nrn2297
   Dantzer R, 2007, BRAIN BEHAV IMMUN, V21, P153, DOI 10.1016/j.bbi.2006.09.006
   de Ferranti SD, 2006, CLIN CHEM, V52, P1325, DOI 10.1373/clinchem.2006.067181
   Deverts DJ, 2012, BRAIN BEHAV IMMUN, V26, P1128, DOI 10.1016/j.bbi.2012.07.017
   Dhabhar FS, 2009, J PSYCHIATR RES, V43, P962, DOI 10.1016/j.jpsychires.2009.05.010
   Dominguez-Rodriguez A, 2009, CURR DRUG TARGETS, V10, P1001, DOI 10.2174/138945009789577963
   Dooley LN, 2018, NEUROSCI BIOBEHAV R, V94, P219, DOI 10.1016/j.neubiorev.2018.09.006
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Duivis HE, 2015, HEALTH PSYCHOL, V34, P1047, DOI 10.1037/hea0000210
   Eisenberger NI, 2017, NEUROPSYCHOPHARMACOL, V42, P242, DOI 10.1038/npp.2016.141
   Falkenstrom F, 2017, J CONSULT CLIN PSYCH, V85, P537, DOI 10.1037/ccp0000203
   Felger JC, 2018, BRAIN BEHAV IMMUN, V73, P163, DOI 10.1016/j.bbi.2018.08.003
   Fried EI, 2014, PSYCHOL MED, V44, P2067, DOI 10.1017/S0033291713002900
   Gilman SE, 2003, PSYCHOL MED, V33, P1341, DOI 10.1017/S0033291703008377
   Gimeno D, 2009, PSYCHOL MED, V39, P413, DOI 10.1017/S0033291708003723
   Goodwin RD, 2004, PSYCHOL MED, V34, P1465, DOI 10.1017/S0033291704002739
   Hankin BL, 1998, J ABNORM PSYCHOL, V107, P128, DOI 10.1037/0021-843X.107.1.128
   HART BL, 1988, NEUROSCI BIOBEHAV R, V12, P123, DOI 10.1016/S0149-7634(88)80004-6
   HOLM S, 1979, SCAND J STAT, V6, P65
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Huang CY, 2014, J CHILD FAM STUD, V23, P255, DOI 10.1007/s10826-013-9807-1
   Janeway CA, 2013, J IMMUNOL, V191, P4475
   Khandaker GM, 2014, JAMA PSYCHIAT, V71, P1121, DOI 10.1001/jamapsychiatry.2014.1332
   Klein DN, 2005, J CLIN CHILD ADOLESC, V34, P412, DOI 10.1207/s15374424jccp3403_3
   KOVACS M, 1985, PSYCHOPHARMACOL BULL, V21, P995
   Krishnadas R, 2016, PSYCHOSOM MED, V78, P384, DOI 10.1097/PSY.0000000000000339
   Kuhlman KR, 2018, BRAIN BEHAV IMMUN, V69, P540, DOI 10.1016/j.bbi.2018.02.001
   Kuznetsova A, 2017, J STAT SOFTW, V82, P1, DOI 10.18637/jss.v082.i13
   Mac Giollabhui N, 2020, PSYCHOL MED, V50, P683, DOI 10.1017/S0033291719000564
   Malarkey WB, 2013, BRAIN BEHAV IMMUN, V27, P145, DOI 10.1016/j.bbi.2012.10.009
   Meyer T, 2011, BEHAV MED, V37, P105, DOI 10.1080/08964289.2011.609192
   Miller AH, 2009, BIOL PSYCHIAT, V65, P732, DOI 10.1016/j.biopsych.2008.11.029
   Miller GE, 2002, HEALTH PSYCHOL, V21, P531, DOI 10.1037//0278-6133.21.6.531
   Miller GE, 2012, BIOL PSYCHIAT, V72, P34, DOI 10.1016/j.biopsych.2012.02.034
   Mills NT, 2013, J CHILD PSYCHOL PSYC, V54, P816, DOI 10.1111/jcpp.12080
   Moriarity DP, 2019, CLIN PSYCHOL SCI, V7, P754, DOI 10.1177/2167702619826586
   Morris AA, 2011, PSYCHOSOM MED, V73, P462, DOI 10.1097/PSY.0b013e318222379c
   Ohayon MM, 2003, ARCH GEN PSYCHIAT, V60, P39, DOI 10.1001/archpsyc.60.1.39
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Preiss K, 2013, OBES REV, V14, P906, DOI 10.1111/obr.12052
   R Core Team, 2019, R LANG ENV STAT COMP
   Raison CL, 2013, JAMA PSYCHIAT, V70, P31, DOI 10.1001/2013.jamapsychiatry.4
   Rights JD, 2019, PSYCHOL METHODS, V24, P309, DOI 10.1037/met0000184
   Rosenkranz MA, 2013, BRAIN BEHAV IMMUN, V27, P174, DOI 10.1016/j.bbi.2012.10.013
   Skovlund C, 2016, JAMA PSYCHIAT, V73, P1154, DOI 10.1001/jamapsychiatry.2016.2387
   Stewart JC, 2009, BRAIN BEHAV IMMUN, V23, P936, DOI 10.1016/j.bbi.2009.04.011
   van Lang NDJ, 2007, J AFFECT DISORDERS, V97, P137, DOI 10.1016/j.jad.2006.06.007
   Wasserstein RL, 2016, AM STAT, V70, P129
   Watkins LR, 1999, P NATL ACAD SCI USA, V96, P7710, DOI 10.1073/pnas.96.14.7710
   Whooley MA, 2006, JAMA-J AM MED ASSOC, V295, P2874, DOI 10.1001/jama.295.24.2874
   Zalli A, 2016, PSYCHOPHARMACOLOGY, V233, P1669, DOI 10.1007/s00213-015-3919-9
NR 62
TC 45
Z9 49
U1 0
U2 15
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2167-7026
EI 2167-7034
J9 CLIN PSYCHOL SCI
JI Clin. Psychol. Sci.
PD JUL
PY 2020
VL 8
IS 4
BP 690
EP 703
AR 2167702620917458
DI 10.1177/2167702620917458
EA MAY 2020
PG 14
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA MJ8BK
UT WOS:000534112500001
PM 32724728
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Wang, KJ
   Zhou, ZH
   Huang, L
   Kan, QH
   Wang, ZC
   Wu, WB
   Yao, C
AF Wang, Kangjie
   Zhou, Zhihao
   Huang, Lin
   Kan, Qinghui
   Wang, Zhecun
   Wu, Weibin
   Yao, Chen
TI PINK1 dominated mitochondria associated genes signature predicts
   abdominal aortic aneurysm with metabolic syndrome
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Article
DE Mitochondria; Abdominal aortic aneurysm; Metabolic syndrome; Machine
   learning; Nomoscore
ID PERIPHERAL ARTERIAL-DISEASE; ATHEROSCLEROSIS; INFLAMMATION;
   PATHOGENESIS; MACROPHAGES; MECHANISMS; STRESS
AB Abdominal aortic aneurysm (AAA) is typically asymptomatic but a devastating cardiovascular disorder, with overall mortality exceeding 80 % once it ruptures. Some patients with AAA may also have comorbid metabolic syndrome (MS), suggesting a potential common underlying pathogenesis. Mitochondrial dysfunction has been reported as a key factor contributing to the deterioration of both AAA and MS. However, the intricate interplay between metabolism and mitochondrial function, both contributing to the development of AAA, has not been thoroughly explored.In this study, we identified candidate genes related to mitochondrial function in AAA and MS. Subsequently, we developed a nomoscore model comprising hub genes (PINK1, ACSL1, CYP27A1, and SLC25A11), identified through the application of two machine learning algorithms, to predict AAA. We observed a marked disparity in immune infiltration profiles between high-and low-nomoscore groups. Furthermore, we confirmed a significant upregulation of the expression of the four hub genes in AAA tissues. Among these, ACSL1 showed relatively higher expression in LPS-treated RAW264.7 cell lines, while CYP27A1 exhibited a notable decrease. Moreover, SLC25A11 displayed a significant upregulation in AngII-treated VSMCs. Conversely, the expression level of PINK1 declined in LPS-stimulated RAW264.7 cell lines but significantly increased in AngII-treated VSMCs. In vivo experiments revealed that the activation of PINK1-mediated mitophagy inhibited the development of AAA in mice.In this current study, we have innovatively identified four mitochondrial function-related genes through in-tegrated bioinformatic analysis. This discovery sheds light on the regulatory mechanisms and unveils promising therapeutic targets for the comorbidity of AAA and MS.
C1 [Wang, Kangjie; Zhou, Zhihao; Huang, Lin; Kan, Qinghui; Wang, Zhecun; Wu, Weibin; Yao, Chen] Sun Yat Sen Univ, Affiliated Hosp 1, Div Vasc Surg, Guangzhou 510080, Peoples R China.
   [Wang, Kangjie; Zhou, Zhihao; Huang, Lin; Kan, Qinghui] Sun Yat sen Univ, Affiliated Hosp 1, Natl Guangdong Joint Engn Lab Diag & Treatment Vas, Guangzhou 510080, Peoples R China.
C3 Sun Yat Sen University; Sun Yat Sen University
RP Wang, ZC; Wu, WB; Yao, C (corresponding author), Sun Yat Sen Univ, Affiliated Hosp 1, Div Vasc Surg, Guangzhou 510080, Peoples R China.
EM wangzhc7@mail.sysu.edu.cn; wuweib@mail2.sysu.edu.cn;
   yaochen@mail.sysu.edu.cn
RI Wang, Kangjie/GQH-4238-2022; wang, zhecun/GWM-5103-2022; Wu,
   Weibin/AAJ-6174-2020; Huang, Lin/M-2262-2019; Yao, Chen/JVD-6226-2023
FU National Natural Science Founda-tion of China [82070495, 82200544,
   82200542]; Natural Science Foundation of Guangdong Provincial
   [2023A1515011602]; Postdoctoral Science Foundation of China
   [2022M723645]
FX <B>Funding</B> This study was supported by the National Natural Science
   Founda-tion of China (grant numbers: 82070495, 82200544 and 82200542) ,
   the Natural Science Foundation of Guangdong Provincial (2023A1515011602)
   , the Postdoctoral Science Foundation of China (2022M723645) .
CR Anagnostakos J, 2021, PROG CARDIOVASC DIS, V65, P34, DOI 10.1016/j.pcad.2021.03.009
   Bonomini F, 2015, AGING DIS, V6, P109, DOI 10.14336/AD.2014.0305
   Bravo-San Pedro JM, 2017, CIRC RES, V120, P1812, DOI 10.1161/CIRCRESAHA.117.311082
   Chen SQ, 2022, J INFLAMM RES, V15, P3719, DOI 10.2147/JIR.S371545
   Cooper HA, 2021, CARDIOVASC RES, V117, P971, DOI 10.1093/cvr/cvaa133
   De Rango P, 2014, EUR J VASC ENDOVASC, V47, P243, DOI 10.1016/j.ejvs.2013.12.007
   Friedman J, 2010, J STAT SOFTW, V33, P1, DOI 10.18637/jss.v033.i01
   Gallo M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017827
   Golledge J, 2019, NAT REV CARDIOL, V16, P225, DOI 10.1038/s41569-018-0114-9
   Graham A, 2015, FREE RADICAL BIO MED, V89, P982, DOI 10.1016/j.freeradbiomed.2015.08.010
   Green DR, 2011, SCIENCE, V333, P1109, DOI 10.1126/science.1201940
   Guo YM, 2020, MED SCI MONITOR, V26, DOI 10.12659/MSM.926766
   Hamacher-Brady A, 2016, CELL MOL LIFE SCI, V73, P775, DOI 10.1007/s00018-015-2087-8
   Hou YF, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.630269
   Kanter JE, 2013, TRENDS ENDOCRIN MET, V24, P137, DOI 10.1016/j.tem.2012.10.002
   Kanter JE, 2012, P NATL ACAD SCI USA, V109, pE715, DOI 10.1073/pnas.1111600109
   Kiyuna LA, 2018, FREE RADICAL BIO MED, V129, P155, DOI 10.1016/j.freeradbiomed.2018.09.019
   Kugo H, 2018, ANN VASC DIS, V11, P159, DOI 10.3400/avd.ra.17-00130
   Kuivaniemi H, 2015, EXPERT REV CARDIOVAS, V13, P975, DOI 10.1586/14779072.2015.1074861
   Langfelder P, 2008, BMC BIOINFORMATICS, V9, DOI 10.1186/1471-2105-9-559
   Lash LH, 2006, CHEM-BIOL INTERACT, V163, P54, DOI 10.1016/j.cbi.2006.03.001
   Lazarou M, 2015, NATURE, V524, P309, DOI 10.1038/nature14893
   Lemieux I, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113501
   Li ZQ, 2020, CELL SIGNAL, V70, DOI 10.1016/j.cellsig.2020.109575
   Liberzon A, 2015, CELL SYST, V1, P417, DOI 10.1016/j.cels.2015.12.004
   Lu S, 2022, AUTOIMMUN REV, V21, DOI 10.1016/j.autrev.2022.103164
   Miyama N, 2010, J VASC SURG, V52, P975, DOI 10.1016/j.jvs.2010.05.086
   Moore KJ, 2011, CELL, V145, P341, DOI 10.1016/j.cell.2011.04.005
   Murphy E, 2016, CIRC RES, V118, P1960, DOI 10.1161/RES.0000000000000104
   Newman AM, 2015, NAT METHODS, V12, P453, DOI [10.1038/NMETH.3337, 10.1038/nmeth.3337]
   Ning YX, 2009, LIPIDS, V44, P511, DOI 10.1007/s11745-009-3299-1
   Nordon IM, 2011, NAT REV CARDIOL, V8, P92, DOI 10.1038/nrcardio.2010.180
   Olijhoek JK, 2004, EUR HEART J, V25, P342, DOI 10.1016/j.ehj.2003.12.007
   Onishi M, 2021, EMBO J, V40, DOI 10.15252/embj.2020104705
   Ouyang MQ, 2021, CARDIOVASC THER, V2021, DOI 10.1155/2021/6615400
   Patil KR, 2005, P NATL ACAD SCI USA, V102, P2685, DOI 10.1073/pnas.0406811102
   Picatoste B, 2023, FRONT CARDIOVASC MED, V10, DOI 10.3389/fcvm.2023.1112430
   Pirih FQ, 2021, PERIODONTOL 2000, V87, P50, DOI 10.1111/prd.12379
   Quintana RA, 2019, CIRC RES, V124, P607, DOI 10.1161/CIRCRESAHA.118.313187
   Raffort J, 2018, CARDIOVASC RES, V114, P1702, DOI 10.1093/cvr/cvy174
   Rath S, 2021, NUCLEIC ACIDS RES, V49, pD1541, DOI 10.1093/nar/gkaa1011
   Roldán-Montero R, 2022, SCI ADV, V8, DOI 10.1126/sciadv.abm7322
   Seillier M, 2015, EMBO MOL MED, V7, P802, DOI 10.15252/emmm.201404318
   Shi F, 2020, CLIN APPL THROMB-HEM, V26, DOI 10.1177/1076029620932226
   Song PG, 2023, ANN SURG, V277, P912, DOI 10.1097/SLA.0000000000005716
   Sorrentino V, 2018, ANNU REV PHARMACOL, V58, P353, DOI 10.1146/annurev-pharmtox-010716-104908
   Subramanian A, 2005, P NATL ACAD SCI USA, V102, P15545, DOI 10.1073/pnas.0506580102
   Sun WL, 2015, J MOL CELL CARDIOL, V81, P96, DOI 10.1016/j.yjmcc.2015.02.005
   Tan HL, 2023, INT J BIOL SCI, V19, P66, DOI 10.7150/ijbs.73936
   Tang Kailin, 2021, Nucleic Acids Res, V49, pe99, DOI 10.1093/nar/gkab554
   Trostchansky A, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/3274296
   Tsushima K, 2018, CIRC RES, V122, P58, DOI 10.1161/CIRCRESAHA.117.311307
   Usui F, 2015, ARTERIOSCL THROM VAS, V35, P127, DOI 10.1161/ATVBAHA.114.303763
   Wang HZ, 2016, BMC BIOINFORMATICS, V17, DOI 10.1186/s12859-016-0900-5
   Wassink AMJ, 2008, EUR HEART J, V29, P213, DOI 10.1093/eurheartj/ehm582
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Wu HK, 2020, AUTOPHAGY, V16, P683, DOI [10.1080/15548627.2019.1635380, 10.1080/15548627.2019.1596482]
   Wu SY, 2022, FRONT GENET, V13, DOI 10.3389/fgene.2022.816035
   Yin YF, 2023, ACTA PHARM SIN B, V13, P1956, DOI 10.1016/j.apsb.2023.01.015
   Yu GC, 2012, OMICS, V16, P284, DOI 10.1089/omi.2011.0118
   Zamorano-Leon JJ, 2020, ANN VASC SURG, V67, P482, DOI 10.1016/j.avsg.2020.02.005
   Zhao GZ, 2021, CARDIOVASC RES, V117, P1402, DOI 10.1093/cvr/cvaa214
   Zhao Y, 2018, INFLAMMATION, V41, P1590, DOI 10.1007/s10753-018-0835-2
   Zhao ZW, 2021, ATHEROSCLEROSIS, V327, P76, DOI 10.1016/j.atherosclerosis.2021.04.002
   Zhou YY, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-09234-6
NR 65
TC 3
Z9 3
U1 0
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD FEB
PY 2024
VL 1870
IS 2
AR 166919
DI 10.1016/j.bbadis.2023.166919
EA NOV 2023
PG 15
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA Z9FA5
UT WOS:001115045700001
PM 38251428
OA hybrid
DA 2025-06-11
ER

PT J
AU Widmer, A
   Mercante, MG
   Silver, HJ
AF Widmer, Annaliese
   Mercante, Margaret G.
   Silver, Heidi J.
TI TG/HDL Ratio Is an Independent Predictor for Estimating Resting Energy
   Expenditure in Adults with Normal Weight, Overweight, and Obesity
SO NUTRIENTS
LA English
DT Article
DE insulin resistance; obesity; resting energy expenditure; TG; HDL ratio
ID INSULIN-RESISTANCE; METABOLIC-RATE; MITOCHONDRIAL DYSFUNCTION; OXIDATIVE
   STRESS; BODY-COMPOSITION; TRIGLYCERIDE; GLUCOSE; ASSOCIATIONS;
   CHOLESTEROL; LIVER
AB Factors that determine resting energy expenditure (REE) remain under investigation, particularly in persons with a high body mass index (BMI). The accurate estimation of energy expenditure is essential for conducting comprehensive nutrition assessments, planning menus and meals, prescribing weight and chronic disease interventions, and the prevention of malnutrition. This study aimed to: (a) determine the contribution of cardiometabolic biomarkers to the inter-individual variation in REE in persons categorized by BMI; and (b) assess the contribution of these biomarkers in the prediction of REE when persons of varying BMI status were categorized by their glycemic and metabolic syndrome status. Baseline data from 645 adults enrolled in diet intervention trials included REE measured by indirect calorimetry, body composition by dual energy X-ray absorptiometry, anthropometrics, and cardiometabolic biomarkers. Multivariate linear regression modeling was conducted to determine the most parsimonious model that significantly predicted REE by BMI category, metabolic syndrome status, and glycemic status. Modeling with the traditional predictors (age, sex, height, weight) accounted for 58-63% of the inter-individual variance in REE. When including age, sex, height, weight and fat-free mass as covariates, adding TG/HDL to regression modeling accounted for 71-87% of the variance in REE. The finding that TG/HDL is an independent predictor in estimating REE was further confirmed when participants were categorized by metabolic syndrome status and by glycemic status. The clinical utility of calculating the TG/HDL ratio not only aids health care providers in identifying patients with impaired lipid metabolism but can optimize the estimation of REE to better meet therapeutic goals for weight and disease management.
C1 [Widmer, Annaliese; Silver, Heidi J.] Vanderbilt Univ, Dept Med, Med Ctr, Nashville, TN 37232 USA.
   [Mercante, Margaret G.] Vanderbilt Univ, Coll Arts & Sci, Nashville, TN 37212 USA.
   [Silver, Heidi J.] Tennessee Valley Healthcare Syst, Dept Vet Affairs, Nashville, TN 37212 USA.
C3 Vanderbilt University; Vanderbilt University; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); VA Tennessee Valley
   Healthcare System
RP Silver, HJ (corresponding author), Vanderbilt Univ, Dept Med, Med Ctr, Nashville, TN 37232 USA.; Silver, HJ (corresponding author), Tennessee Valley Healthcare Syst, Dept Vet Affairs, Nashville, TN 37212 USA.
EM heidi.j.silver@vumc.org
OI Silver, Heidi/0000-0003-2237-4903; , Margaret/0000-0002-3376-1864;
   Widmer, Annaliese/0000-0002-4647-3589
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Amer Diabet Assoc, 2021, DIABETES CARE, V44, pS73, DOI 10.2337/dc21-S006
   Borén J, 2022, NAT REV CARDIOL, V19, P577, DOI 10.1038/s41569-022-00676-y
   Bosy-Westphal A, 2008, AM J CLIN NUTR, V87, P1695, DOI 10.1093/ajcn/87.6.1695
   Boudina S, 2014, EXP PHYSIOL, V99, P1168, DOI 10.1113/expphysiol.2014.081414
   Carey VJ, 2010, AM J CARDIOL, V106, P757, DOI 10.1016/j.amjcard.2010.05.002
   Chauhan A, 2021, J FAM MED PRIM CARE, V10, P3700, DOI 10.4103/jfmpc.jfmpc_165_21
   Compher C, 2006, J AM DIET ASSOC, V106, P881, DOI 10.1016/j.jada.2006.02.009
   Das M, 2021, ENDOCRINOLOGY, V162, DOI 10.1210/endocr/bqaa158
   De Fano M, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23105511
   DEFRONZO RA, 1979, AM J PHYSIOL, V237, pE214
   Drabsch T, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00556
   Fan NG, 2019, LIPIDS HEALTH DIS, V18, DOI 10.1186/s12944-019-0986-7
   FERRANNINI E, 1988, METABOLISM, V37, P287, DOI 10.1016/0026-0495(88)90110-2
   FRAYN KN, 1983, J APPL PHYSIOL, V55, P628, DOI 10.1152/jappl.1983.55.2.628
   Ginsberg HN, 2021, EUR HEART J, V42, P4791, DOI 10.1093/eurheartj/ehab551
   Gong RP, 2021, ENDOCR CONNECT, V10, P1502, DOI 10.1530/EC-21-0414
   González-Chávez A, 2011, CIR CIR, V79, P115
   Gormsen LC, 2009, AM J PHYSIOL-ENDOC M, V296, pE165, DOI 10.1152/ajpendo.90675.2008
   Gougeon R, 2002, INT J OBESITY, V26, P1547, DOI 10.1038/sj.ijo.0802178
   Harris JA, 1918, P NATL ACAD SCI USA, V4, P370, DOI 10.1073/pnas.4.12.370
   Iwani NAKZ, 2017, SCI REP-UK, V7, DOI 10.1038/srep40055
   Kimm H, 2010, CIRC J, V74, P931, DOI 10.1253/circj.CJ-09-0571
   Korenblat KM, 2008, GASTROENTEROLOGY, V134, P1369, DOI 10.1053/j.gastro.2008.01.075
   LAWS A, 1992, J INTERN MED, V231, P25, DOI 10.1111/j.1365-2796.1992.tb00494.x
   Li CY, 2008, CARDIOVASC DIABETOL, V7, DOI 10.1186/1475-2840-7-4
   Lin DZ, 2018, CLIN NUTR, V37, P1423, DOI 10.1016/j.clnu.2017.06.018
   Lockman KA, 2012, LIVER INT, V32, P1079, DOI 10.1111/j.1478-3231.2012.02775.x
   Manzoni G, 2020, DIABETES METAB SYNDR, V13, P489, DOI 10.2147/DMSO.S228229
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Montgomery MK, 2015, ENDOCR CONNECT, V4, DOI 10.1530/EC-14-0092
   Murguía-Romero M, 2013, J LIPID RES, V54, P2795, DOI 10.1194/jlr.M040584
   Paradies G, 2014, WORLD J GASTROENTERO, V20, P14205, DOI 10.3748/wjg.v20.i39.14205
   Reaven G, 2011, ARTERIOSCL THROM VAS, V31, P954, DOI 10.1161/ATVBAHA.111.224790
   Ren XX, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0154345
   Ryan M, 2006, BRIT J NUTR, V96, P945, DOI 10.1017/BJN20061744
   Salazar MR, 2011, DIABETES VASC DIS RE, V8, P109, DOI 10.1177/1479164111403170
   Schofield W N, 1985, Hum Nutr Clin Nutr, V39 Suppl 1, P5
   Shook RP, 2014, MAYO CLIN PROC, V89, P763, DOI 10.1016/j.mayocp.2013.12.017
   Silver HJ, 2013, OBESITY, V21, P765, DOI 10.1002/oby.20287
   Soares M, 2022, METABOLITES, V12, DOI 10.3390/metabo12080722
   Wallace TM, 2004, DIABETES CARE, V27, P1487, DOI 10.2337/diacare.27.6.1487
   WEIR JBD, 1949, J PHYSIOL-LONDON, V109, P1, DOI 10.1113/jphysiol.1949.sp004363
   Weyer C, 1999, INT J OBESITY, V23, P715, DOI 10.1038/sj.ijo.0800910
   Weyer C, 1999, DIABETES, V48, P1607, DOI 10.2337/diabetes.48.8.1607
   Yang Q, 2018, NAT REV MOL CELL BIO, V19, P654, DOI 10.1038/s41580-018-0044-8
   Young KA, 2019, J DIABETES COMPLICAT, V33, P118, DOI 10.1016/j.jdiacomp.2018.10.018
NR 47
TC 3
Z9 4
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2022
VL 14
IS 23
AR 5106
DI 10.3390/nu14235106
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 6X6NF
UT WOS:000896527600001
PM 36501139
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lai, CH
   Huang, RJ
   Wong, JKS
   Chang, SW
   Chung, AH
   Chi, YC
   Yu, YC
   Lee, SD
   Ting, H
AF Lai, Ching-Hsiang
   Huang, Ren-Jing
   Wong, James Kok-Suh
   Chang, Shen-Wen
   Chung, Ai-Hui
   Chi, Yung-Chun
   Yu, Yi-Chen
   Lee, Shin-Da
   Ting, Hua
TI Confounded by obesity and modulated by urinary uric acid excretion,
   sleep-disordered breathing indirectly relates to hyperuricaemia in
   males: A structural equation model
SO JOURNAL OF SLEEP RESEARCH
LA English
DT Article
DE hepatic dysfunction; metabolic syndrome; obstructive sleep apnea; renal
   dysfunction
ID AIRWAY PRESSURE THERAPY; METABOLIC SYNDROME; SERUM URATE; APNEA;
   DISEASE; FITNESS; METAANALYSIS; ASSOCIATION; REDUCTION; HYPOXEMIA
AB Sleep-disordered breathing (SDB) causes hypoxic stress and can trigger uric acid (UA) overproduction. We comprehensively investigated whether SDB, interacting with components of metabolic syndrome, hepatic and renal dysfunctions, low physical fitness, sedentary lifestyle, disrupted sleep, and chronic systemic inflammation (CSI), is directly associated with hyperuricaemia. In 528 community-based males (mean [SD] age 46.2 [7.4] years), we cross-sectionally analysed measures of anthropometry; self-reported lifestyle habits; overnight sleep polysomnography data; cardiopulmonary exercise tests; and biomarkers of cardiometabolic, hepatic, and renal functions; and CSI, using structural equation modelling. Objective disrupted sleep, C-reactive protein, low physical fitness, and sedentary lifestyle were not related to UA levels in univariate analysis and were excluded. The latent variables (with corresponding manifest variables) obesity (body mass index, waist-hip ratio), hypertension (post-sleep systolic, diastolic blood pressure), dyslipidaemia (total cholesterol, triglyceride/high-density lipoprotein cholesterol), hepatic dysfunction (alanine aminotransferase, aspartate transaminase), and renal dysfunction (blood urea nitrogen, serum creatinine) were positively; and hyperglycaemia (fasting glucose, glycated haemoglobin) was negatively associated with hyperuricaemia (serum UA), except for SDB (Apnea-Hypopnea Index, percentage of oxygen saturation <90% period against total sleep time, oxygen desaturation index) in the one-stage influence model. In the two-stage model, SDB, closely interacting with obesity, was positively indirectly associated with hyperuricaemia through directly linked renal dysfunction and obesity-linked hypertension, inverse hyperglycaemia, dyslipidaemia, and hepatic dysfunction. In conclusion, structural equation modelling reveals that SDB closely interacts with obesity and is positively but indirectly related to hyperuricaemia in males. This suggests that urinary UA excretion modulates and obesity confounds the SDB-hyperuricaemia relationship.
C1 [Lai, Ching-Hsiang] Chung Shan Med Univ, Dept Med Informat, Taichung, Taiwan.
   [Huang, Ren-Jing] Chung Shan Med Univ, Dept Med Image & Radiol Sci, Taichung, Taiwan.
   [Wong, James Kok-Suh] Asia Univ Hosp, Dept Cardiol, Taichung, Taiwan.
   [Chang, Shen-Wen; Chung, Ai-Hui; Ting, Hua] Chung Shan Med Univ Hosp, Sleep Med Ctr, 110,Sec 1,Jianguo N Rd, Taichung 40201, Taiwan.
   [Chi, Yung-Chun; Yu, Yi-Chen; Ting, Hua] Chung Shan Med Univ Hosp, Dept Phys Med & Rehabil, Taichung, Taiwan.
   [Lee, Shin-Da] China Med Univ, Grad Inst Rehabil Sci, Dept Phys Therapy, Taichung, Taiwan.
   [Lee, Shin-Da] Asia Univ, Dept Occupat Therapy, Taichung, Taiwan.
   [Lee, Shin-Da] Shanghai Univ TCM, Sch Rehabil Sci, Affiliated People Hosp 7, Shanghai, Peoples R China.
   [Ting, Hua] Chung Shan Med Univ, Inst Med, Taichung, Taiwan.
C3 Chung Shan Medical University; Chung Shan Medical University; Chung Shan
   Medical University; Chung Shan Medical University Hospital; Chung Shan
   Medical University; Chung Shan Medical University Hospital; China
   Medical University Taiwan; Asia University Taiwan; Shanghai University
   of Traditional Chinese Medicine; Chung Shan Medical University
RP Ting, H (corresponding author), Chung Shan Med Univ Hosp, Sleep Med Ctr, 110,Sec 1,Jianguo N Rd, Taichung 40201, Taiwan.; Ting, H (corresponding author), Chung Shan Med Univ Hosp, Dept Phys Med & Rehabil, Taichung, Taiwan.; Ting, H (corresponding author), Chung Shan Med Univ, Inst Med, Taichung, Taiwan.
EM huating@csmu.edu.tw
RI Lee, Shin-Da/Q-2798-2015; Wang, Pa-Chun/AAD-4094-2019; Chuang,
   Hung-Yi/C-9143-2009
FU Shanghai Institute of Higher Education [2012-47]; Taiwan Ministry of
   Health and Welfare [MOHW106-TDU-B-212-113004]
FX Shanghai Institute of Higher Education, Grant/Award Number: 2012-47;
   Taiwan Ministry of Health and Welfare, Grant/Award Number:
   MOHW106-TDU-B-212-113004
CR Abrams B, 2010, JCR-J CLIN RHEUMATOL, V16, P305, DOI 10.1097/RHU.0b013e3181ef724d
   Bonora E, 1996, INT J OBESITY, V20, P975
   BRAGHIROLI A, 1993, AM REV RESPIR DIS, V148, P173, DOI 10.1164/ajrccm/148.1.173
   Church TS, 2002, INT J OBESITY, V26, P805, DOI 10.1038/sj.ijo.0802001
   Ford ES, 2007, CIRCULATION, V115, P2526, DOI 10.1161/CIRCULATIONAHA.106.657627
   Gaines J, 2017, PHYSIOL REP, V5, DOI 10.14814/phy2.13454
   Gaines J, 2015, BRAIN BEHAV IMMUN, V47, P211, DOI 10.1016/j.bbi.2014.11.013
   Hirotsu C, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0066891
   JENSEN MH, 1980, BIOL NEONATE, V38, P40
   Johnson RJ, 2013, NEPHROL DIAL TRANSPL, V28, P2221, DOI 10.1093/ndt/gft029
   Kanbay A, 2014, EUR J INTERN MED, V25, P471, DOI 10.1016/j.ejim.2014.04.005
   Keenan T, 2012, AM J CARDIOL, V110, P1787, DOI 10.1016/j.amjcard.2012.08.012
   Leyva F, 1998, METABOLISM, V47, P1156, DOI 10.1016/S0026-0495(98)90293-1
   Li J, 1985, J APPL PHYSIOL, V102, P557, DOI [10.1152/japplphysiol.01081.2006.2007, DOI 10.1152/JAPPLPHYSIOL.01081.2006.2007]
   Liu PW, 2010, METABOLISM, V59, P802, DOI 10.1016/j.metabol.2009.09.027
   Lu WL, 2012, J CLIN LIPIDOL, V6, P159, DOI 10.1016/j.jacl.2011.11.006
   Madero M, 2015, J AM SOC HYPERTENS, V9, P837, DOI 10.1016/j.jash.2015.07.008
   Nagaya N, 1999, AM J RESP CRIT CARE, V160, P487, DOI 10.1164/ajrccm.160.2.9812078
   Nishida Y, 2011, INTERNAL MED, V50, P2121, DOI 10.2169/internalmedicine.50.5506
   Ozanturk E, 2016, REV PORT PNEUMOL, V22, P18, DOI 10.1016/j.rppnen.2015.06.002
   Prudon B, 2013, SLEEP MED, V14, P1419, DOI 10.1016/j.sleep.2013.09.001
   Reinke C, 1985, J APPL PHYSIOL, V111, P881
   Reis LN, 2017, J PEDIAT-BRAZIL, V93, P538, DOI 10.1016/j.jped.2016.11.011
   García AR, 2006, ARCH BRONCONEUMOL, V42, P492, DOI 10.1016/S1579-2129(06)60575-2
   Saito H, 2002, CHEST, V122, P1686, DOI 10.1378/chest.122.5.1686
   Seetho IW, 2015, CHRON RESP DIS, V12, P238, DOI 10.1177/1479972315586197
   SHICHIRI M, 1987, ARCH INTERN MED, V147, P225, DOI 10.1001/archinte.147.2.225
   Steiropoulos P, 2009, SLEEP, V32, P537, DOI 10.1093/sleep/32.4.537
   Ting H, 2005, AUTON NEUROSCI-BASIC, V121, P74, DOI 10.1016/j.autneu.2005.05.007
   Trayhurn P, 2013, PHYSIOL REV, V93, P1, DOI 10.1152/physrev.00017.2012
   Trzepizur W, 2013, CHEST, V143, P1584, DOI 10.1378/chest.12-1652
   Vgontzas AN, 2013, SLEEP MED REV, V17, P241, DOI 10.1016/j.smrv.2012.09.005
   Villegas R, 2010, METAB SYNDR RELAT D, V8, P263, DOI 10.1089/met.2009.0084
   Wei FJ, 2016, SCI REP-UK, V6, DOI 10.1038/srep28549
   YAMASHITA S, 1986, INT J OBESITY, V10, P255
   Yuan HP, 2015, J CLIN ENDOCR METAB, V100, P4198, DOI 10.1210/jc.2015-2527
   Zhao G, 2013, ATHEROSCLEROSIS, V231, P61, DOI 10.1016/j.atherosclerosis.2013.08.023
   Zou HQ, 2015, J CHROMATOGR B, V1006, P59, DOI 10.1016/j.jchromb.2015.10.027
NR 38
TC 3
Z9 3
U1 1
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1105
EI 1365-2869
J9 J SLEEP RES
JI J. Sleep Res.
PD JUN
PY 2021
VL 30
IS 3
AR e13108
DI 10.1111/jsr.13108
EA AUG 2020
PG 11
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA SI6YK
UT WOS:000556232000001
PM 32767532
DA 2025-06-11
ER

PT J
AU Tomassoni, D
   Martinelli, I
   Moruzzi, M
   Di Bonaventura, MVM
   Cifani, C
   Amenta, F
   Tayebati, SK
AF Tomassoni, Daniele
   Martinelli, Ilenia
   Moruzzi, Michele
   Di Bonaventura, Maria Vittoria Micioni
   Cifani, Carlo
   Amenta, Francesco
   Tayebati, Seyed Khosrow
TI Obesity and Age-Related Changes in the Brain of the
   ZuckerLepr<SUP>fa/fa</SUP>Rats
SO NUTRIENTS
LA English
DT Article
DE brain alterations; diabetes; metabolic syndrome; neuromorphology;
   obesity; Zucker rats
ID BODY-MASS INDEX; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; PROVISIONAL
   REPORT; OXIDATIVE STRESS; LIPID PEROXIDES; HEART-DISEASE; RATS;
   MICROGLIA; WEIGHT
AB Metabolic syndrome (MetS) is an association between obesity, dyslipidemia, hyperglycemia, hypertension, and insulin resistance. A relationship between MetS and vascular dementia was hypothesized. The purpose of this work is to investigate brain microanatomy alterations in obese Zucker rats (OZRs), as a model of MetS, compared to their counterparts lean Zucker rats (LZRs). 12-, 16-, and 20-weeks-old male OZRs and LZRs were studied. General physiological parameters and blood values were measured. Immunochemical and immunohistochemical techniques were applied to analyze the brain alterations. The morphology of nerve cells and axons, astrocytes and microglia were investigated. The blood-brain barrier (BBB) changes occurring in OZRs were assessed as well using aquaporin-4 (AQP4) and glucose transporter protein-1 (GLUT1) as markers. Body weight gain, hypertension, hyperglycemia, and hyperlipidemia were found in OZRs compared to LZRs. In the frontal cortex and hippocampus, a decrease of neurons was noticeable in the older obese rats in comparison to their age-matched lean counterparts. In OZRs, a reduction of neurofilament immunoreaction and gliosis was observed. The BBB of older OZRs revealed an increased expression of AQP4 likely related to the development of edema. A down-regulation of GLUT1 was found in OZRs of 12 weeks of age, whereas it increased in older OZRs. The behavioral analysis revealed cognitive alterations in 20-week-old OZRs. Based on these results, the OZRs may be useful for understanding the mechanisms through which obesity and related metabolic alterations induce neurodegeneration.
C1 [Tomassoni, Daniele] Univ Camerino, Sch Biosci & Vet Med, Via Gentile III Varano, I-62032 Camerino, Italy.
   [Martinelli, Ilenia; Di Bonaventura, Maria Vittoria Micioni; Cifani, Carlo; Amenta, Francesco; Tayebati, Seyed Khosrow] Univ Camerino, Sch Pharm, Via Madonna Carceri 9, I-62032 Camerino, Italy.
   [Moruzzi, Michele] Univ Leipzig, Dept Med, Liebigstr 21, D-04103 Leipzig, Germany.
C3 University of Camerino; University of Camerino; Leipzig University
RP Cifani, C; Tayebati, SK (corresponding author), Univ Camerino, Sch Pharm, Via Madonna Carceri 9, I-62032 Camerino, Italy.
EM daniele.tomassoni@unicam.it; ilenia.martinelli@unicam.it;
   michele.moruzzi@medizin.uni-leipzig.de; mariavittoria.micioni@unicam.it;
   carlo.cifani@unicam.it; francesco.amenta@unicam.it;
   khosrow.tayebati@unicam.it
RI Micioni Di Bonaventura, Maria Vittoria/AAC-5447-2022; Cifani,
   Carlo/AAC-5456-2022; Tayebati, Seyed/AGK-8739-2022
OI Micioni Di Bonaventura, Maria Vittoria/0000-0002-8044-1206; Francesco,
   Amenta/0000-0002-0555-1034; Cifani, Carlo/0000-0001-6180-828X;
   MARTINELLI, ILENIA/0000-0002-7702-7784; Tayebati, Seyed
   Khosrow/0000-0002-7219-6917; Tomassoni, Daniele/0000-0001-9062-3305
CR Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   de Artiñano AA, 2009, BRIT J NUTR, V102, P1246, DOI 10.1017/S0007114509990729
   Anjum I, 2018, CUREUS J MED SCIENCE, V10, DOI 10.7759/cureus.2660
   [Anonymous], 2021, OB OV
   ARMSTRONG D, 1994, ADV EXP MED BIOL, V366, P43
   Arshad NA, 2018, CNS NEUROL DISORD-DR, V17, P595, DOI 10.2174/1871527317666180724143258
   Bailey KR, 2009, FRONT NEUROSCI, P77
   Balkau B, 1999, DIABETIC MED, V16, P442
   Brooks SD, 2015, AM J PHYSIOL-HEART C, V309, pH1846, DOI 10.1152/ajpheart.00691.2015
   Brown GC, 2014, NAT REV NEUROSCI, V15, P209, DOI 10.1038/nrn3710
   CamargoDeMorais M, 1996, NEUROCHEM RES, V21, P595, DOI 10.1007/BF02527758
   Di Bonaventura MVM, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030623
   Di Bonaventura MVM, 2017, INT J EAT DISORDER, V50, P624, DOI 10.1002/eat.22687
   Di Bonaventura MVM, 2013, PSYCHOPHARMACOLOGY, V228, P53, DOI 10.1007/s00213-013-3013-0
   Dinel AL, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024325
   Dommermuth R, 2018, PRIMARY CARE, V45, P109, DOI 10.1016/j.pop.2017.10.003
   Erdös B, 2004, DIABETES, V53, P1352, DOI 10.2337/diabetes.53.5.1352
   Erickson MA, 2012, NEUROIMMUNOMODULAT, V19, P121, DOI 10.1159/000330247
   Etchegoyen M, 2018, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00196
   Feinkohl I, 2019, BMC GERIATR, V19, DOI 10.1186/s12877-019-1073-7
   Flegal KM, 2013, JAMA-J AM MED ASSOC, V309, P71, DOI 10.1001/jama.2012.113905
   Garden GA, 2006, J NEUROIMMUNE PHARM, V1, P127, DOI 10.1007/s11481-006-9015-5
   Georgsson L, 2001, SCAND J LAB ANIM SCI, V28, P201
   Gispen WH, 2000, TRENDS NEUROSCI, V23, P542, DOI 10.1016/S0166-2236(00)01656-8
   Gonder JC, 2007, ILAR J, V48, P29, DOI 10.1093/ilar.48.1.29
   Hou WK, 2007, CHINESE MED J-PEKING, V120, P1704, DOI 10.1097/00029330-200710010-00013
   Hwang IK, 2014, NEUROL RES, V36, P824, DOI 10.1179/1743132814Y.0000000330
   Jolivel V, 2015, ACTA NEUROPATHOL, V129, P279, DOI 10.1007/s00401-014-1372-1
   Kalayci R, 2009, INT J NEUROSCI, V119, P1881, DOI 10.1080/14647270802336650
   Krohn TC, 2006, ANIM WELFARE, V15, P343
   Lee MK, 1996, ANNU REV NEUROSCI, V19, P187, DOI 10.1146/annurev.ne.19.030196.001155
   Li C, 2007, OBESITY, V15, P216, DOI 10.1038/oby.2007.505
   Liddelow SA, 2017, IMMUNITY, V46, P957, DOI 10.1016/j.immuni.2017.06.006
   Lin F, 2014, DEMENT GER COGN D EX, V4, P184, DOI 10.1159/000363285
   Maes HHM, 1997, BEHAV GENET, V27, P325, DOI 10.1023/A:1025635913927
   Malone JI, 2006, BRAIN RES, V1076, P9, DOI 10.1016/j.brainres.2005.12.072
   Martinelli I, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21062035
   Martinelli I, 2017, CNS NEUROL DISORD-DR, V16, P664, DOI 10.2174/1871527316666170428123853
   MCEWEN BS, 1995, CURR OPIN NEUROBIOL, V5, P205, DOI 10.1016/0959-4388(95)80028-X
   McMurray CT, 2000, CELL DEATH DIFFER, V7, P861, DOI 10.1038/sj.cdd.4400764
   Messier C, 2004, NEUROL RES, V26, P567, DOI 10.1179/016164104225016263
   Michikawa M, 2003, J NEUROSCI RES, V72, P141, DOI 10.1002/jnr.10585
   Milionis HJ, 2008, CNS SPECTRUMS, V13, P606, DOI 10.1017/S1092852900016886
   Olsson IAS, 2007, APPL ANIM BEHAV SCI, V103, P229, DOI 10.1016/j.applanim.2006.05.022
   Peterson R.G., 1990, ILAR NEWS, V32, P16, DOI DOI 10.1093/ILAR.32.3.16
   Poirier P, 2006, CIRCULATION, V113, P898, DOI 10.1161/CIRCULATIONAHA.106.171016
   Rebolledo-Solleiro Daniela, 2017, PLoS One, V12, pe0176554, DOI 10.1371/journal.pone.0176554
   Ricci G, 2017, CLIN EXP HYPERTENS, V39, P8, DOI 10.1080/10641963.2016.1210629
   Sabbatini M, 2001, MECH AGEING DEV, V122, P2085, DOI 10.1016/S0047-6374(01)00318-9
   Sickmann HM, 2010, J CEREBR BLOOD F MET, V30, P1527, DOI 10.1038/jcbfm.2010.61
   Sofroniew MV, 2015, NAT REV NEUROSCI, V16, P249, DOI 10.1038/nrn3898
   Srinivasan K, 2007, INDIAN J MED RES, V125, P451
   Sripetchwandee J, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00496
   Tangvarasittichai S, 2015, WORLD J DIABETES, V6, P456, DOI 10.4239/wjd.v6.i3.456
   Tayebati SK, 2016, CNS NEUROL DISORD-DR, V15, P995, DOI 10.2174/1871527315666160527155014
   Tayebati SK, 2017, NUTRIENTS, V9, DOI 10.3390/nu9101084
   Tomassoni D, 2004, CLIN EXP HYPERTENS, V26, P305, DOI 10.1081/CEH-120034136
   Tomassoni D, 2013, NEUROSCI LETT, V543, P136, DOI 10.1016/j.neulet.2013.03.025
   Tomassoni D, 2010, BRAIN RES, V1325, P155, DOI 10.1016/j.brainres.2010.02.023
   Van Dyken P, 2018, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00930
   Van Loo PLP, 2001, PHYSIOL BEHAV, V72, P675, DOI 10.1016/S0031-9384(01)00425-5
   van Praag H, 2014, J NEUROSCI, V34, P15139, DOI 10.1523/JNEUROSCI.2814-14.2014
   Wang J, 2015, J COMP NEUROL, V523, P757, DOI 10.1002/cne.23708
   Winocur G, 2005, BEHAV NEUROSCI, V119, P1389, DOI 10.1037/0735-7044.119.5.1389
   Wohlfart P, 2014, ACTA DIABETOL, V51, P553, DOI 10.1007/s00592-013-0550-2
   Wormser D, 2011, LANCET, V377, P1085, DOI 10.1016/S0140-6736(11)60105-0
   Yagi K, 1998, Methods Mol Biol, V108, P101
   Yorek MA, 2016, INT REV NEUROBIOL, V127, P89, DOI 10.1016/bs.irn.2016.03.002
   Yuan AD, 2016, BRAIN RES BULL, V126, P334, DOI 10.1016/j.brainresbull.2016.09.002
   Zhou JP, 2008, NEUROREPORT, V19, P1, DOI 10.1097/WNR.0b013e3282f2b4eb
NR 70
TC 28
Z9 29
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2020
VL 12
IS 5
AR 1356
DI 10.3390/nu12051356
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MB0AV
UT WOS:000542272700024
PM 32397542
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mieno, Y
   Hayashi, M
   Sakakibara, H
   Takahashi, H
   Fujite, S
   Isogai, S
   Goto, Y
   Uozu, S
   Okazawa, M
   Imaizumi, K
AF Mieno, Yuki
   Hayashi, Masamichi
   Sakakibara, Hiroki
   Takahashi, Hiroshi
   Fujite, Shiho
   Isogai, Sumito
   Goto, Yasuhiro
   Uozu, Sakurako
   Okazawa, Mitsushi
   Imaizumi, Kazuyoshi
TI Gender Differences in the Clinical Features of Sleep Apnea Syndrome
SO INTERNAL MEDICINE
LA English
DT Article
DE sleep apnea; gender; polysomnography; metabolic syndrome
ID POSITIVE AIRWAY PRESSURE; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; GLUCOSE; POPULATION; PREVALENCE; COHORT; ADULTS; WOMEN
AB Objective Sleep apnea syndrome is more prevalent among men than women and is frequently accompanied by metabolic syndrome (MetS). However, gender differences in the effect of sleep-disordered breathing (SDB) leading to the risk of MetS remain unclear. The aim of our study was to investigate the clinical characteristics of SDB in women and the differential influence of SDB on MetS between genders.
   Methods In a single-center retrospective study, we compared the data of 1,809 consecutive SDB patients by gender to clarify the characteristics of sleep disorders in women. We also compared the prevalence of MetS and its related abnormalities by gender. A logistic regression analysis was used to determine the contributory factors for MetS.
   Results The mean age and proportion of patients over 50 years of age were higher in women than in men. SDB was milder in women than in men according to polysomnography findings. Elevated Hemoglobin A1c levels and hyperlipidemia were less frequent in women than in men. The MetS prevalence was similar in women and men (30.0% vs. 35.2%). A logistic regression analysis showed that the apnea-hypopnea index (AHI) was an independent risk factor for MetS in both genders, but that female gender was independently associated with a decreased prevalence of MetS and its related abnormalities.
   Conclusion Female SDB patients tend to be older with milder apnea and sleepiness than male SDB patients. A higher AHI is a significant risk factor for MetS in both genders, although female gender is an independent inhibitory factor for developing MetS in SDB patients.
C1 [Mieno, Yuki; Hayashi, Masamichi; Isogai, Sumito; Goto, Yasuhiro; Uozu, Sakurako; Imaizumi, Kazuyoshi] Fujita Hlth Univ, Dept Resp Med, Toyoake, Aichi, Japan.
   [Sakakibara, Hiroki] Tokushige Resp Clin, Nagoya, Aichi, Japan.
   [Takahashi, Hiroshi] Fujita Hlth Univ, Dept Med Stat, Toyoake, Aichi, Japan.
   [Fujite, Shiho] Fujita Hlth Univ, Dept Lab Med, Toyoake, Aichi, Japan.
   [Okazawa, Mitsushi] Daiyukai Hosp, Dept Resp Med, Ichinomiya, Japan.
C3 Fujita Health University; Fujita Health University; Fujita Health
   University
RP Mieno, Y (corresponding author), Fujita Hlth Univ, Dept Resp Med, Toyoake, Aichi, Japan.
EM mienon@fujita-hu.ac.jp
RI Hayashi, Masamichi/P-9743-2015
CR [Anonymous], 2005, INT CLASSIFICATION S, V2nd
   Dancey DR, 2003, CHEST, V123, P1544, DOI 10.1378/chest.123.5.1544
   Flemons WW, 1999, SLEEP, V22, P667, DOI 10.1093/sleep/22.5.667
   Harsch IA, 2004, AM J RESP CRIT CARE, V169, P156, DOI 10.1164/rccm.200302-206OC
   Hu HH, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-2856-9
   Ip MSM, 2002, AM J RESP CRIT CARE, V165, P670, DOI 10.1164/ajrccm.165.5.2103001
   Kent BD, 2014, CHEST, V146, P982, DOI 10.1378/chest.13-2403
   KONO S, 1990, MATURITAS, V12, P43, DOI 10.1016/0378-5122(90)90059-F
   Kuzuya T, 2002, DIABETES RES CLIN PR, V55, P65, DOI 10.1016/S0168-8227(01)00365-5
   Lavie L, 2003, SLEEP MED REV, V7, P35, DOI 10.1053/smrv.2002.0261
   Marin JM, 2005, LANCET, V365, P1046, DOI 10.1016/S0140-6736(05)71141-7
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Ninomiya T, 2007, STROKE, V38, P2063, DOI 10.1161/STROKEAHA.106.479642
   Oyama J, 2012, CLIN CARDIOL, V35, P231, DOI 10.1002/clc.21010
   Parish JM, 2007, J CLIN SLEEP MED, V3, P467
   Popovic RM, 1998, J APPL PHYSIOL, V84, P1055, DOI 10.1152/jappl.1998.84.3.1055
   Punjabi NM, 2009, PLOS MED, V6, DOI 10.1371/journal.pmed.1000132
   Punjabi NM, 2004, AM J EPIDEMIOL, V160, P521, DOI 10.1093/aje/kwh261
   Punjabi NM, 2002, AM J RESP CRIT CARE, V165, P677, DOI 10.1164/ajrccm.165.5.2104087
   Rechtschaffen A., 1968, MANUAL STANDARDIZED
   Reichmuth KJ, 2005, AM J RESP CRIT CARE, V172, P1590, DOI 10.1164/rccm.200504-637OC
   Sasanabe R, 2006, HYPERTENS RES, V29, P315, DOI 10.1291/hypres.29.315
   SEKIKAWA A, 1993, DIABETES CARE, V16, P570, DOI 10.2337/diacare.16.4.570
   Strohl KP, 1996, AM J RESP CRIT CARE, V154, P279, DOI 10.1164/ajrccm.154.2.8756795
   Treatment Guideline Production Committee, 2002, GOUT NUCL ACID MET S, V26
   Trombetta IC, 2010, SLEEP, V33, P1193, DOI 10.1093/sleep/33.9.1193
   Tufik S, 2010, SLEEP MED, V11, P441, DOI 10.1016/j.sleep.2009.10.005
   Wolk R, 2003, HYPERTENSION, V42, P1067, DOI 10.1161/01.HYP.0000101686.98973.A3
   Young T, 2003, AM J RESP CRIT CARE, V167, P1181, DOI 10.1164/rccm.200209-1055OC
   YOUNG T, 1993, NEW ENGL J MED, V328, P1230, DOI 10.1056/NEJM199304293281704
NR 30
TC 9
Z9 12
U1 0
U2 3
PU JAPAN SOC INTERNAL MEDICINE
PI TOKYO
PA 34-3 3-CHOME HONGO BUNKYO-KU, TOKYO, 113, JAPAN
SN 0918-2918
EI 1349-7235
J9 INTERNAL MED
JI Intern. Med.
PY 2018
VL 57
IS 15
BP 2157
EP 2163
DI 10.2169/internalmedicine.7570-16
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GP3WB
UT WOS:000440784200008
PM 29607972
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chen, Y
   Zhou, Z
   Li, XX
   Wang, T
AF Chen, Y.
   Zhou, Z.
   Li, X. -X.
   Wang, T.
TI Research on the protective effects of antioxidants on metabolic syndrome
   induced by thyroid dysfunction (Withdrawn Publication)
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article; Withdrawn Publication
DE Impact factor; Metabolic syndrome; Thyroid abnormality; Numerical
   analysis algorithm
ID DENTAL PLAQUE; ASSOCIATION
AB OBJECTIVE: This paper researches on the protective effects of antioxidants on metabolic syndrome induced by thyroid dysfunction. While the role of Lipoic acid (LA), Resveratrol (R) and Quercetin (Q) are recognized, the mechanisms for their ameliorative effects are partially understood. Therefore, the objective of this study was to determine the prevalence of MS among university workers and to examine the relationship with thyroid function and mechanisms for protective effects of LA, Resveratrol and Quercetin on the heart, kidneys and lungs.
   SUBJECTS AND METHODS: In the cross-sectional study, a total of 2273 university workers (1198 males and 1075 females) aged 2260 participated. Anthropometric measurements (weight and height), blood pressure, fasting plasma glucose (FPG), lipids, liver and kidney function tests were carried out, thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), total antioxidant capacity (T-AOC), lipid peroxidation products, malondialdehyde (MDA), advanced oxidation protein products (AOPP) and dityrosine levels were measured.
   RESULTS: A further evaluation of oxidative stress markers in subclinical hypothyroidism (SCH) compared with normal thyroid function showed the differences. Among middle-aged men with SCH (n = 467), MDA concentrations (8.11 +/- 1.39 nmol/ml) were significantly higher euthyroid controls (7.34 +/- 1.31 nmol/ml; n = 190) while AOPP, dityrosine and T-AOC levels were not different.
   CONCLUSIONS: It was demonstrated that prevalence of MS components was high. Targeting thyroid hormone restoration, inhibition of ACE and GSK3 via PI3K/AKT signaling path-way using LA, Resveratrol and Quercetin are potential novel therapeutic approaches for developing pharmaceuticals that could make significance in MS treatment.
C1 [Chen, Y.] Zhengzhou Univ, Affiliated Hosp 2, Dept Gerontol, Zhengzhou, Henan Province, Peoples R China.
   [Zhou, Z.] Zhengzhou Univ, Affiliated Hosp 2, Dept Resp Med, Zhengzhou, Henan Province, Peoples R China.
   [Li, X. -X.] Zhengzhou Univ, Affiliated Hosp 2, Dept Neurol, Zhengzhou, Henan Province, Peoples R China.
   [Wang, T.] Zhengzhou Univ, Affiliated Hosp 2, Dept Cardiol, Zhengzhou, Henan Province, Peoples R China.
C3 Zhengzhou University; Zhengzhou University; Zhengzhou University;
   Zhengzhou University
RP Wang, T (corresponding author), Zhengzhou Univ, Affiliated Hosp 2, Dept Cardiol, Zhengzhou, Henan Province, Peoples R China.
EM wangtao116848@163.com
RI WANG, Tiange/KEE-8267-2024
OI Wang, Tiange/0000-0003-0723-489X
FU Foundation of Henan Educational Committee [17A320009]
FX Foundation of Henan Educational Committee (Fund code: 17A320009.
CR Baxi R, 2016, J DIABETES, V8, P494, DOI 10.1111/1753-0407.12319
   Bittar DG, 2014, J BIOMED OPT, V19, DOI 10.1117/1.JBO.19.6.065004
   Blusková Z, 2014, J PEDIATR ENDOCR MET, V27, P693, DOI 10.1515/jpem-2013-0334
   Kowalczyk K, 2017, EUR REV MED PHARMACO, V21, P346
   Laterza L, 2016, EUR REV MED PHARMACO, V20, P685
   Montanari G, 2010, MINERVA PEDIATR, V62, P9
   Neilands J, 2014, ARCH ORAL BIOL, V59, P318, DOI 10.1016/j.archoralbio.2013.12.008
   oga U, 2015, EUR REV MED PHARMACO, V19, P396
   Peng XG, 2015, EUR REV MED PHARMACO, V19, P235
   Sands KM, 2016, J MED MICROBIOL, V65, P147, DOI 10.1099/jmm.0.000212
   Sieminska L, 2015, ENDOKRYNOL POL, V66, P394, DOI 10.5603/EP.2015.0049
   Takamura T., 2009, J JPN SOC PAIN CLIN, V11, P439
   Tan L, 2014, J PERIODONTAL RES, V49, P760, DOI 10.1111/jre.12159
   Turan T, 2017, EUR REV MED PHARMACO, V21, P576
   Wang SX, 2015, J RES MED SCI, V20, P963, DOI 10.4103/1735-1995.172785
   Yin JH, 2014, INT J ENDOCRINOL, V2014, DOI 10.1155/2014/675796
NR 16
TC 2
Z9 2
U1 0
U2 13
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PD MAY
PY 2017
VL 21
IS 10
BP 2489
EP 2498
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EZ3ZP
UT WOS:000404650900027
PM 28617535
DA 2025-06-11
ER

PT J
AU Cardinali, DP
   Hardeland, R
AF Cardinali, Daniel P.
   Hardeland, Ruediger
TI Inflammaging, Metabolic Syndrome and Melatonin: A Call for Treatment
   Studies
SO NEUROENDOCRINOLOGY
LA English
DT Article
DE Melatonin; Metabolic syndrome; Inflammation; Diabetes; Obesity; Insulin
   signaling; Aging
ID HIGH-FAT DIET; ERYTHROID 2-RELATED FACTOR-2; HUMAN-PLATELET-AGGREGATION;
   INDUCED INSULIN-RESISTANCE; POLYCYSTIC-OVARY-SYNDROME; NOCTURNAL
   BLOOD-PRESSURE; TYPE-2 DIABETIC-PATIENTS; NUCLEAR FACTOR-KAPPAB;
   OXIDATIVE STRESS; WEIGHT-GAIN
AB The metabolic syndrome (MS) is a collection of risk factors for cardiovascular disease, including obesity, hypertension, hyperinsulinemia, glucose intolerance and dyslipidemia. MS is associated with low-grade inflammation of the white adipose tissue, which can subsequently lead to insulin resistance, impaired glucose tolerance and diabetes. Adipocytes secrete proinflammatory cytokines as well as leptin and trigger a vicious circle which leads to additional weight gain largely as fat. The imbalance between inflammatory and anti-inflammatory signals is crucial to aging. Healthy aging can benefit from melatonin, a compound known to possess direct and indirect antioxidant properties, to have a significant protective effect on mitochondrial function, to enhance circadian rhythm amplitudes, to modulate the immune system and to exhibit neuroprotective actions. Melatonin levels decrease in the course of senescence and are more strongly reduced in diseases related to insulin resistance. This short review article analyzes the multiple protective actions of melatonin that are relevant to the attenuation of inflammatory responses and progression of inflammaging and how melatonin is effective to curtail MS in animal models of hyperadiposity. The clinical data supporting the possible therapeutic use of melatonin in human MS are also reviewed. Since attention has been focused on the development of potent melatonin analogs with prolonged effects (ramelteon, agomelatine, tasimelteon, piromelatine) and in clinical trials these analogs were administered in doses considerably higher than those usually employed for melatonin, clinical trials on melatonin in the range of 50-100 mg/day are needed to further assess its therapeutic value in MS. (C) 2016 S. Karger AG, Basel
C1 [Cardinali, Daniel P.] Pontificia Univ Catolica Argentina, BIOMED UCA CONICET, Buenos Aires, DF, Argentina.
   [Cardinali, Daniel P.] Pontificia Univ Catol Argentina, Dept Teaching & Res, Fac Med Sci, Av Alicia Moreau de Justo 1500,4 Piso, RA-1107 Buenos Aires, DF, Argentina.
   [Hardeland, Ruediger] Univ Gottingen, Johann Friedrich Blumenbach Inst Zool & Anthropol, Gottingen, Germany.
C3 Pontificia Universidad Catolica Argentina; Pontificia Universidad
   Catolica Argentina; University of Gottingen
RP Cardinali, DP (corresponding author), Pontificia Univ Catol Argentina, Dept Teaching & Res, Fac Med Sci, Av Alicia Moreau de Justo 1500,4 Piso, RA-1107 Buenos Aires, DF, Argentina.
EM danielcardinali@uca.edu.ar
FU Agencia Nacional de Promocion Cientifica y Tecnologica, Argentina [2007
   01045, 2012 0984]
FX Studies conducted in Daniel P. Cardinali's laboratory were supported by
   grants PICT 2007 01045 and 2012 0984 from the Agencia Nacional de
   Promocion Cientifica y Tecnologica, Argentina.
CR Agil A, 2015, J PINEAL RES, V59, P70, DOI 10.1111/jpi.12241
   Agil A, 2013, J PINEAL RES, V54, P381, DOI 10.1111/jpi.12012
   Agil A, 2011, J PINEAL RES, V50, P207, DOI 10.1111/j.1600-079X.2010.00830.x
   Altun A, 2002, NEUROSCI LETT, V327, P143, DOI 10.1016/S0304-3940(02)00368-3
   [Anonymous], 2011, J EXP INTEG MED
   Arpaci D, 2015, J OVARIAN RES, V8, DOI 10.1186/s13048-015-0197-4
   Balistreri CR, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/802078
   Barnea M, 2012, BBA-MOL BASIS DIS, V1822, P1796, DOI 10.1016/j.bbadis.2012.08.005
   Bartness TJ, 2002, EXP BIOL MED, V227, P363, DOI 10.1177/153537020222700601
   Bellet MM, 2011, COLD SH Q B, V76, P31, DOI 10.1101/sqb.2011.76.010520
   Boivin DB, 2003, BLOOD, V102, P4143, DOI 10.1182/blood-2003-03-0779
   Bollinger T, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0029801
   Boren E, 2004, AUTOIMMUN REV, V3, P401, DOI 10.1016/j.autrev.2004.03.004
   BRUGGER P, 1995, LANCET, V345, P1408, DOI 10.1016/S0140-6736(95)92600-3
   Cagnacci A, 2005, AM J HYPERTENS, V18, P1614, DOI 10.1016/j.amjhyper.2005.05.008
   Candore G, 2010, BIOGERONTOLOGY, V11, P565, DOI 10.1007/s10522-010-9286-3
   Barquilla PC, 2014, J PINEAL RES, V57, P280, DOI 10.1111/jpi.12168
   Cardinali Daniel P., 2004, Current Drug Targets - Immune Endocrine and Metabolic Disorders, V4, P1, DOI 10.2174/1568008043340071
   Cardinali DP, 2013, HORM BEHAV, V63, P322, DOI 10.1016/j.yhbeh.2012.02.020
   Cardinali DP, 2013, INT J MOL SCI, V14, P2502, DOI 10.3390/ijms14022502
   Cardinali DP, 2012, J PINEAL RES, V52, P365, DOI 10.1111/j.1600-079X.2011.00962.x
   Carrillo-Vico A, 2013, INT J MOL SCI, V14, P8638, DOI 10.3390/ijms14048638
   Caruso C, 2000, HUM IMMUNOL, V61, P942, DOI 10.1016/S0198-8859(00)00168-3
   Cavallo A, 2004, PEDIATR DIABETES, V5, P26, DOI 10.1111/j.1399-543X.2004.00031.x
   Cavallo A, 2004, J PINEAL RES, V36, P262, DOI 10.1111/j.1600-079X.2004.00126.x
   Cevenini E, 2013, CURR OPIN CLIN NUTR, V16, P14, DOI 10.1097/MCO.0b013e32835ada13
   Chatham JC, 2013, J MOL CELL CARDIOL, V55, P139, DOI 10.1016/j.yjmcc.2012.06.016
   Ciortea R, 2011, ANTICANCER RES, V31, P2637
   Contreras-Alcantara S, 2010, OBESITY, V18, P1861, DOI 10.1038/oby.2010.24
   Cuesta S, 2013, AGE, V35, P659, DOI 10.1007/s11357-012-9397-7
   Cuesta S, 2011, MECH AGEING DEV, V132, P573, DOI 10.1016/j.mad.2011.10.005
   Cuesta S, 2010, EXP GERONTOL, V45, P950, DOI 10.1016/j.exger.2010.08.016
   De la Fuente M, 2009, CURR PHARM DESIGN, V15, P3003, DOI 10.2174/138161209789058110
   De Pedro N, 2008, J PINEAL RES, V45, P32, DOI 10.1111/j.1600-079X.2007.00553.x
   DelaRosa O, 2006, BIOGERONTOLOGY, V7, P471, DOI 10.1007/s10522-006-9062-6
   DELZAR MD, 1990, J CLIN ENDOCR METAB, V70, P246
   DELZAR MDM, 1990, ACTA ENDOCRINOL-COP, V123, P453, DOI 10.1530/acta.0.1230453
   Demirtas CY, 2015, EUR REV MED PHARMACO, V19, P1915
   Ding K, 2014, NEUROCHEM INT, V76, P23, DOI 10.1016/j.neuint.2014.06.015
   Domínguez-Rodríguez A, 2002, J PINEAL RES, V33, P248, DOI 10.1034/j.1600-079X.2002.02938.x
   Du YP, 2014, PROTEIN CELL, V5, P203, DOI 10.1007/s13238-014-0030-7
   Escames G, 2010, CURR NEUROPHARMACOL, V8, P182, DOI 10.2174/157015910792246245
   Esquifino A, 1997, LIFE SCI, V61, P1051, DOI 10.1016/S0024-3205(97)00613-9
   Esser N, 2015, ACTA CLIN BELG, V70, P193, DOI 10.1179/2295333715Y.0000000004
   Favero G, 2015, NUTR RES, V35, P891, DOI 10.1016/j.nutres.2015.07.001
   Forman K, 2011, J GERONTOL A-BIOL, V66, P823, DOI 10.1093/gerona/glr083
   Franceschi C, 2000, ANN NY ACAD SCI, V908, P244
   Franceschi C, 2003, BIOCHEM SOC T, V31, P457, DOI 10.1042/BST0310457
   Galley HF, 2014, J PINEAL RES, V56, P427, DOI 10.1111/jpi.12134
   Girotti L, 2000, J PINEAL RES, V29, P138, DOI 10.1034/j.1600-079X.2000.290302.x
   Gonciarz M, 2012, J PHYSIOL PHARMACOL, V63, P35
   Gonciarz M, 2010, J PHYSIOL PHARMACOL, V61, P705
   Goyal A, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-124
   Grossman E, 2006, AM J MED, V119, P898, DOI 10.1016/j.amjmed.2006.02.002
   Grossman E, 2011, VASC HEALTH RISK MAN, V7, P577, DOI 10.2147/VHRM.S24603
   Gubin Denis G, 2016, Curr Aging Sci, V9, P5
   Hardeland R, 2015, PROG NEUROBIOL, V127, P46, DOI 10.1016/j.pneurobio.2015.02.001
   Hardeland R, 2014, INT J MOL SCI, V15, P18221, DOI 10.3390/ijms151018221
   Hardeland R, 2015, INTERD T GERONT GERI, V40, P128, DOI 10.1159/000364975
   Hardeland R, 2013, J PINEAL RES, V55, P325, DOI 10.1111/jpi.12090
   Hardeland R, 2012, AGING DIS, V3, P194
   Hardeland R, 2012, J PINEAL RES, V52, P139, DOI 10.1111/j.1600-079X.2011.00934.x
   Hardeland R, 2011, PROG NEUROBIOL, V93, P350, DOI 10.1016/j.pneurobio.2010.12.004
   Hardeland R, 2009, MOLECULES, V14, P5054, DOI 10.3390/molecules14125054
   Hardeland R, 2009, BIOFACTORS, V35, P183, DOI 10.1002/biof.23
   Hatzis G, 2013, WORLD J HEPATOL, V5, P160, DOI 10.4254/wjh.v5.i4.160
   Huang L, 2013, EUR REV MED PHARMACO, V17, P2449
   Huber M, 2013, EUR J INTERN MED, V24, P650, DOI 10.1016/j.ejim.2013.03.015
   Hussain SAR, 2007, J PINEAL RES, V42, P267, DOI 10.1111/j.1600-079X.2006.00415.x
   Hussain SA, 2006, SAUDI MED J, V27, P1483
   Jacob S, 2002, J PINEAL RES, V33, P186, DOI 10.1034/j.1600-079X.2002.02943.x
   Jung KH, 2010, J PINEAL RES, V48, P239, DOI 10.1111/j.1600-079X.2010.00748.x
   Jung KH, 2009, J PINEAL RES, V47, P173, DOI 10.1111/j.1600-079X.2009.00698.x
   Kanter M, 2006, ARCH TOXICOL, V80, P362, DOI 10.1007/s00204-005-0055-z
   Kesse-Guyot E, 2015, AGE AGEING, V44, P648, DOI 10.1093/ageing/afv053
   King H, 1998, DIABETES CARE, V21, P1414, DOI 10.2337/diacare.21.9.1414
   Kireev RA, 2008, J PINEAL RES, V45, P394, DOI 10.1111/j.1600-079X.2008.00606.x
   Kireev RA, 2014, AGE, V36, DOI 10.1007/s11357-014-9707-3
   Kitagawa A, 2012, J PINEAL RES, V52, P403, DOI 10.1111/j.1600-079X.2011.00955.x
   Korkmaz A, 2012, GENE, V503, P1, DOI 10.1016/j.gene.2012.04.040
   Koziróg M, 2011, J PINEAL RES, V50, P261, DOI 10.1111/j.1600-079X.2010.00835.x
   Ladizesky MG, 2003, J PINEAL RES, V34, P143, DOI 10.1034/j.1600-079X.2003.00021.x
   Maestroni GJM, 2005, J NEUROIMMUNOL, V158, P106, DOI 10.1016/j.jneuroim.2004.08.015
   Makki Kassem, 2013, ISRN Inflamm, V2013, P139239, DOI 10.1155/2013/139239
   Mazepa RC, 1999, LIFE SCI, V66, P153
   McMullan CJ, 2013, AM J EPIDEMIOL, V178, P231, DOI 10.1093/aje/kws470
   Mesri Alamdari N, 2015, HORM METAB RES, V47, P504, DOI 10.1055/s-0034-1384587
   Modabbernia A, 2014, J PSYCHIATR RES, V53, P133, DOI 10.1016/j.jpsychires.2014.02.013
   Mostafavi Ali, 2014, Acta Med Iran, V52, P734
   Mozdzan M, 2014, ARCH MED SCI, V10, P669, DOI 10.5114/aoms.2014.44858
   Mühlbauer E, 2004, FEBS LETT, V564, P91, DOI 10.1016/S0014-5793(04)00322-9
   Nduhirabandi F, 2011, J PINEAL RES, V50, P171, DOI 10.1111/j.1600-079X.2010.00826.x
   Nishida S, 2003, J PINEAL RES, V35, P251, DOI 10.1034/j.1600-079X.2003.00083.x
   Nishida S, 2002, J PINEAL RES, V32, P26, DOI 10.1034/j.1600-079x.2002.10797.x
   Nogueira TC, 2011, ENDOCRINOLOGY, V152, P1253, DOI 10.1210/en.2010-1088
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Obayashi K, 2013, HYPERTENS RES, V36, P736, DOI 10.1038/hr.2013.20
   OBRIEN IAD, 1986, CLIN ENDOCRINOL, V24, P359, DOI 10.1111/j.1365-2265.1986.tb01639.x
   Oxenkrug GF, 2010, ANN NY ACAD SCI, V1199, P114, DOI 10.1111/j.1749-6632.2009.05355.x
   Pai SA, 2014, J PHARM PHARMACOL, V66, P1710, DOI 10.1111/jphp.12297
   Pan M, 2006, J PINEAL RES, V41, P79, DOI 10.1111/j.1600-079X.2006.00346.x
   Pawelec G, 2010, J COMP PATHOL, V141, pS39, DOI 10.1016/j.jcpa.2009.09.005
   Pawelec G, 2009, REV MED VIROL, V19, P47, DOI 10.1002/rmv.598
   Peschke E, 2007, J PINEAL RES, V42, P350, DOI 10.1111/j.1600-079X.2007.00426.x
   Ponnappan S, 2011, ANTIOXID REDOX SIGN, V14, P1551, DOI 10.1089/ars.2010.3228
   Prokopenko I, 2009, NAT GENET, V41, P77, DOI 10.1038/ng.290
   Prunet-Marcassus B, 2003, ENDOCRINOLOGY, V144, P5347, DOI 10.1210/en.2003-0693
   Puchalski SS, 2003, ENDOCRINE, V21, P163, DOI 10.1385/ENDO:21:2:163
   Quan XJ, 2015, BIOCHEM BIOPH RES CO, V463, P1102, DOI 10.1016/j.bbrc.2015.06.065
   Raskind MA, 2007, NEUROPSYCHOPHARMACOL, V32, P284, DOI 10.1038/sj.npp.1301093
   Diez ER, 2013, J PINEAL RES, V55, P166, DOI 10.1111/jpi.12059
   Ríos-Lugo MJ, 2015, HORM MOL BIOL CLIN I, V21, P175, DOI 10.1515/hmbci-2014-0041
   Ríos-Lugo MJ, 2010, J PINEAL RES, V49, P342, DOI 10.1111/j.1600-079X.2010.00798.x
   Romo-Nava F, 2014, BIPOLAR DISORD, V16, P410, DOI 10.1111/bdi.12196
   Rubio-Sastre P, 2014, SLEEP, V37, P1715, DOI 10.5665/sleep.4088
   Sahar Saurabh, 2013, Handb Exp Pharmacol, P29, DOI 10.1007/978-3-642-25950-0_2
   Sakotnik A, 1999, EUR HEART J, V20, P1314, DOI 10.1053/euhj.1999.1527
   Sanchez-Mateos S, 2007, MATURITAS, V58, P91, DOI 10.1016/j.maturitas.2007.06.006
   Sartori C, 2009, ENDOCRINOLOGY, V150, P5311, DOI 10.1210/en.2009-0425
   Sárvári AK, 2014, BIOCHEM BIOPH RES CO, V450, P1383, DOI 10.1016/j.bbrc.2014.07.005
   Bernasconi PAS, 2013, HORM MOL BIOL CLIN I, V16, P101, DOI 10.1515/hmbci-2013-0005
   Scheer FAJL, 2004, HYPERTENSION, V43, P192, DOI 10.1161/01.HYP.0000113293.15186.3b
   Shatilo V B, 2010, Adv Gerontol, V23, P539
   She MH, 2014, BIOCHIMIE, V103, P126, DOI 10.1016/j.biochi.2014.05.001
   She MH, 2014, EUR J PHARMACOL, V727, P60, DOI 10.1016/j.ejphar.2014.01.037
   She MH, 2009, PHARMACOL RES, V59, P248, DOI 10.1016/j.phrs.2009.01.005
   Shieh JM, 2009, J PINEAL RES, V47, P339, DOI 10.1111/j.1600-079X.2009.00720.x
   Smith CJ, 2015, DIABETES METAB SYNDR, V8, P295, DOI 10.2147/DMSO.S61296
   Song X, 2015, EUR J OBSTET GYN R B, V195, P108, DOI 10.1016/j.ejogrb.2015.09.043
   Strindhall J, 2007, EXP GERONTOL, V42, P753, DOI 10.1016/j.exger.2007.05.001
   Stumpf I, 2009, J PINEAL RES, V46, P140, DOI 10.1111/j.1600-079X.2008.00638.x
   Tamura H, 2008, J PINEAL RES, V45, P101, DOI 10.1111/j.1600-079X.2008.00561.x
   Tan DX, 2011, OBES REV, V12, P167, DOI 10.1111/j.1467-789X.2010.00756.x
   Tan DX, 2015, MOLECULES, V20, P18886, DOI 10.3390/molecules201018886
   Tchernof A, 2013, PHYSIOL REV, V93, P359, DOI 10.1152/physrev.00033.2011
   Teodoro BG, 2014, J PINEAL RES, V57, P155, DOI 10.1111/jpi.12157
   Tutuncu NB, 2005, J PINEAL RES, V39, P43, DOI 10.1111/j.1600-079X.2005.00213.x
   VACAS MI, 1991, J PINEAL RES, V11, P135, DOI 10.1111/j.1600-079X.1991.tb00468.x
   Verdile G, 2015, MEDIAT INFLAMM, V2015, DOI 10.1155/2015/105828
   Vinogradova I, 2013, BIOGERONTOLOGY, V14, P401, DOI 10.1007/s10522-013-9437-4
   Weishaupt JH, 2006, J PINEAL RES, V41, P313, DOI 10.1111/j.1600-079X.2006.00377.x
   Welty FK, 2016, TRANSL RES, V167, P257, DOI 10.1016/j.trsl.2015.06.017
   Wirtz PH, 2008, J PINEAL RES, V44, P358, DOI 10.1111/j.1600-079X.2007.00535.x
   Wu UI, 2011, J PINEAL RES, V50, P159, DOI 10.1111/j.1600-079X.2010.00825.x
   Yaprak M, 2003, INT J CARDIOL, V89, P103, DOI 10.1016/S0167-5273(02)00461-8
   Zanquetta MM, 2003, J PINEAL RES, V35, P141, DOI 10.1034/j.1600-079X.2003.00067.x
   Zhang YY, 2014, OBESITY, V22, P691, DOI 10.1002/oby.20528
   Zheng C, 2015, OBESITY, V23, P1022, DOI 10.1002/oby.21030
NR 148
TC 78
Z9 79
U1 0
U2 21
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0028-3835
EI 1423-0194
J9 NEUROENDOCRINOLOGY
JI Neuroendocrinology
PY 2017
VL 104
IS 4
BP 382
EP 397
DI 10.1159/000446543
PG 16
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA EQ8QU
UT WOS:000398351400006
PM 27165273
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Méndez-Albiñana, P
   Rodrigues-Díez, R
   Rodríguez-Rodríguez, P
   Moreno, R
   Muñoz-Valverde, D
   Casani, L
   Villamiel, M
   Blanco-Rivero, J
AF Mendez-Albinana, Pablo
   Rodrigues-Diez, Raquel
   Rodriguez-Rodriguez, Pilar
   Moreno, Rodrigo
   Munoz-Valverde, David
   Casani, Laura
   Villamiel, Mar
   Blanco-Rivero, Javier
TI Structure and properties of citrus pectin as influencing factors of
   biomarkers of metabolic syndrome in rats fed with a high-fat diet
SO CURRENT RESEARCH IN FOOD SCIENCE
LA English
DT Article
DE Citrus pectin; Functional properties; Metabolic syndrome; Insulin
   resistance and hypertension
ID MESENTERIC-ARTERIES; OXIDATIVE STRESS; EXTRACTION; ACID
AB Pectin, widely used as a food and pharmaceutical ingredient, has garnered attention in recent years due to its bioactive properties. We conducted an in vivo study to evaluate the effects of citrus pectin on biomarkers of metabolic syndrome (MtS), including lipid profile, hypertension, and adipose tissue. Supplementing a high-fat diet (60% energy from fat) with 20% pectin for 4 weeks significantly reduced body weight and fat accumulation, improved insulin resistance, and decreased circulating leptin levels, demonstrating a beneficial effect on MtS. Pectin exhibited excellent viscosity, emulsifying properties, and water-holding capacity, forming a viscous gel in the gastrointestinal tract. This gel delays gastric emptying, enhances satiety, and reduces food and calorie intake, leading to lower weight gain in rats fed pectin. Its viscosity also interferes with lipase activity, lipid hydrolysis, and absorption, while its oil-holding capacity may help prevent lipid absorption. The presence of galactose in pectin's structure showed potential for improving insulin resistance. Furthermore, both degree of esterification (DE) and pH influence pectin's functionality. At acidic pH levels, such as those found in the stomach and duodenum, high methoxyl pectin (HMP) retains fats and bile salts more effectively, contributing to better cholesterol regulation. These effects, combined with the antioxidant properties of pectin, helped reverse arterial hypertension associated with MtS. Overall, our findings highlight the potential of citrus pectin as a natural bioactive ingredient for combating obesity-related disorders, complementing pharmacological treatments and promoting health through innovative dietary approaches.
C1 [Mendez-Albinana, Pablo; Rodriguez-Rodriguez, Pilar; Blanco-Rivero, Javier] Univ Autonoma Madrid, Sch Med, Dept Physiol, C Arzobispo Morcillo,4, Madrid 28029, Spain.
   [Mendez-Albinana, Pablo; Villamiel, Mar] UAM, Grp Chem & Funct Carbohydrates & Derivat, Food Sci Res Inst CIAL, CSIC, Madrid, Spain.
   [Rodrigues-Diez, Raquel] Univ Complutense Madrid, Sch Med, Dept Physiol, Madrid, Spain.
   [Rodrigues-Diez, Raquel; Rodriguez-Rodriguez, Pilar; Blanco-Rivero, Javier] Univ Hosp La Paz IdIPaz, Res Inst, Madrid, Spain.
   [Rodrigues-Diez, Raquel; Blanco-Rivero, Javier] Ctr Biomed Res Network CIBER Cardiovasc Dis, Madrid, Spain.
   [Moreno, Rodrigo] CSIC, Inst Ceram & Glass ICV, Madrid, Spain.
   [Munoz-Valverde, David] Univ Autonoma Madrid, Sch Med, Anim Headquarters, Madrid, Spain.
   [Casani, Laura] Santa Creu I St Pau Hosp, Res Inst, Barcelona, Spain.
C3 Autonomous University of Madrid; Autonomous University of Madrid;
   Consejo Superior de Investigaciones Cientificas (CSIC); Complutense
   University of Madrid; Consejo Superior de Investigaciones Cientificas
   (CSIC); CSIC - Instituto de Ceramica y Vidrio (ICV); Autonomous
   University of Madrid
RP Blanco-Rivero, J (corresponding author), Univ Autonoma Madrid, Sch Med, Dept Physiol, C Arzobispo Morcillo,4, Madrid 28029, Spain.; Villamiel, M (corresponding author), Food Sci Res Inst CIAL, Grp Chem & Funct Carbohydrates & Derivat, C Nicolas Cabrera 9, Madrid 28049, Spain.
EM m.villamiel@csic.es; javier.blanco@uam.es
RI Rivero, Javier/ABE-8749-2020; Rodríguez-Rodríguez, Pilar/Q-7664-2016;
   Díez, Raquel/ABE-9703-2020; Moreno, Rodrigo/L-3750-2017; Blanco Rivero,
   Javier/J-6118-2014
OI Moreno, Rodrigo/0000-0002-4826-5193; Mendez Albinana,
   Pablo/0009-0002-0988-2401; Rodrigues Diez, Raquel/0000-0002-6348-1505;
   Blanco Rivero, Javier/0000-0001-7232-2314
FU CiberCV; Ministerio de Ciencia e Innovacion [PID2021-123862OB-100,
   PID2022-138,610OB- 100]; CDTI-Center for Industrial Technological
   Development-project PID 2020-FEDER Funds; Luis Alvarez Fellowship
   (IdIPaz, 2023 Call);  [CB16/11/00286];  [PID2020-116498RB-100]
FX <STRONG> </STRONG>This research was funded by CiberCV (Grant number:
   CB16/11/00286) , and the Ministerio de Ciencia e Innovacion
   (PID2020-116498RB-100, PID2021-123862OB-100, PID2022-138,610OB- 100) ,
   CDTI-Center for Industrial Technological Development-project PID
   2020-FEDER Funds) , and Luis Alvarez Fellowship (IdIPaz, 2023 Call) .
CR Agarkova EY, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122930
   Amor S, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010153
   Andersson KE, 2012, MOL NUTR FOOD RES, V56, P1003, DOI 10.1002/mnfr.201100706
   [Anonymous], 2010, EFSA Journal, V8, DOI 10.2903j.efsa.2010.1747
   Bayar N, 2018, FOOD CHEM, V241, P127, DOI 10.1016/j.foodchem.2017.08.051
   Blanco-Rivero J, 2011, BRIT J PHARMACOL, V162, P271, DOI 10.1111/j.1476-5381.2010.01030.x
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Cabral B, 2021, PLANT FOOD HUM NUTR, V76, P466, DOI 10.1007/s11130-021-00921-8
   Capomolla AS, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061271
   Cervantes-Paz B, 2017, FOOD RES INT, V99, P917, DOI 10.1016/j.foodres.2017.02.012
   Chan SY, 2017, CARBOHYD POLYM, V161, P118, DOI 10.1016/j.carbpol.2016.12.033
   Chandel V, 2022, FOODS, V11, DOI 10.3390/foods11172683
   Cronin P, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051655
   Cui YL, 2023, FOOD HYDROCOLLOID, V136, DOI 10.1016/j.foodhyd.2022.108272
   de Queiroz DB, 2015, BRIT J PHARMACOL, V172, P4699, DOI 10.1111/bph.13244
   Djaoud K, 2022, INT J BIOL MACROMOL, V212, P337, DOI 10.1016/j.ijbiomac.2022.05.115
   Dongowski G, 2004, J NUTR BIOCHEM, V15, P196, DOI 10.1016/S0955-2863(03)00080-9
   Egan BM, 2019, J HYPERTENS, V37, P1148, DOI 10.1097/HJH.0000000000002021
   Evans CEL, 2020, P NUTR SOC, V79, P61, DOI 10.1017/S0029665119000673
   Ferreira-Lazarte A, 2021, INT J BIOL MACROMOL, V167, P1349, DOI 10.1016/j.ijbiomac.2020.11.089
   Ferreira-Lazarte A, 2018, CARBOHYD POLYM, V199, P482, DOI 10.1016/j.carbpol.2018.07.041
   Griendling KK, 2021, CIRC RES, V128, P993, DOI 10.1161/CIRCRESAHA.121.318063
   Hu WC, 2023, NUTRIENTS, V15, DOI 10.3390/nu15010157
   Jong SH, 2023, CARBOHYDR POLYM TECH, V5, DOI 10.1016/j.carpta.2023.100290
   Lian CY, 2020, CHEM-BIOL INTERACT, V330, DOI 10.1016/j.cbi.2020.109199
   Liu N, 2022, FOOD CHEM, V386, DOI 10.1016/j.foodchem.2022.132683
   Llévenes P, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010117
   Luo Liping, 2022, Med Rev (2021), V2, P349, DOI 10.1515/mr-2022-0002
   Maki KC, 2007, EUR J CLIN NUTR, V61, P786, DOI 10.1038/sj.ejcn.1602562
   Martínez-Martí J, 2023, FOOD STRUCT-NETH, V38, DOI 10.1016/j.foostr.2023.100346
   Méndez-Albiñana P, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11040680
   Muñoz-Almagro N, 2021, INT J BIOL MACROMOL, V186, P962, DOI 10.1016/j.ijbiomac.2021.07.016
   Muñoz-Almagro N, 2021, FOOD RES INT, V140, DOI 10.1016/j.foodres.2020.109851
   Muñoz-Almagro N, 2020, FOOD CHEM, V318, DOI 10.1016/j.foodchem.2020.126476
   Muñoz-Labrador A, 2018, J SCI FOOD AGR, V98, P4866, DOI 10.1002/jsfa.9018
   Nadar CG, 2022, ACS ENG AU, V2, P61, DOI 10.1021/acsengineeringau.1c00025
   Gerschenson LN, 2021, FOOD HYDROCOLLOID, V118, DOI 10.1016/j.foodhyd.2021.106799
   Obradovic M, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.585887
   Qin L, 2018, FOOD FUNCT, V9, P243, DOI [10.1039/c7fo01095h, 10.1039/C7FO01095H]
   Ravaut G, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22010330
   Rohm TV, 2022, IMMUNITY, V55, P31, DOI 10.1016/j.immuni.2021.12.013
   Rubio-Senent F, 2015, FOOD HYDROCOLLOID, V43, P311, DOI 10.1016/j.foodhyd.2014.06.001
   Sampson M, 2020, JAMA CARDIOL, V5, P540, DOI 10.1001/jamacardio.2020.0013
   Sánchez D, 2008, J AGR FOOD CHEM, V56, P3574, DOI 10.1021/jf703598j
   Shafie MH, 2020, INT J BIOL MACROMOL, V149, P835, DOI 10.1016/j.ijbiomac.2020.02.013
   SINGLETON V. L., 1965, AMER J ENOL VITICULT, V16, P144
   Sriamomsak Pomsak., 2003, International Journal, V3, P206, DOI DOI 10.5458/JAG.54.211
   Pacheco MT, 2019, MOLECULES, V24, DOI 10.3390/molecules24030392
   Pacheco MT, 2018, FOOD FUNCT, V9, P4888, DOI [10.1039/C8FO01060A, 10.1039/c8fo01060a]
   Torres S, 2019, EUR J NUTR, V58, P27, DOI 10.1007/s00394-018-1790-2
   Van Audenhove J, 2021, FOODS, V10, DOI 10.3390/foods10051064
   Villamiel M., 2021, ES Food & Agroforestry, DOI [10.30919/esfaf1123, DOI 10.30919/ESFAF1123]
   Wang C, 2021, FOOD CHEM, V339, DOI 10.1016/j.foodchem.2020.128064
   Wang WJ, 2016, FOOD HYDROCOLLOID, V61, P730, DOI 10.1016/j.foodhyd.2016.06.019
   Wei RJ, 2021, CARBOHYD POLYM, V264, DOI 10.1016/j.carbpol.2021.118040
   Yang N, 2024, INT J BIOL MACROMOL, V262, DOI 10.1016/j.ijbiomac.2024.130212
   Yu M, 2022, BIOCHEM PHARMACOL, V202, DOI 10.1016/j.bcp.2022.115121
NR 57
TC 0
Z9 0
U1 6
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2665-9271
J9 CURR RES FOOD SCI
JI Curr. Res. Food Sci.
PY 2025
VL 10
AR 101014
DI 10.1016/j.crfs.2025.101014
PG 10
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA Z6W2K
UT WOS:001440276100001
PM 40114745
OA gold
DA 2025-06-11
ER

PT J
AU Roudi, F
   Darroudi, S
   Saghi, E
   Hosseini, SR
   Kohantorabi, M
   Rezvani, A
   Jamialahmadi, T
   Sahebkar, A
   Moohebati, M
   Ghayour-Mobarhan, M
AF Roudi, Fatemeh
   Darroudi, Susan
   Saghi, Effat
   Hosseini, Seyed Reza
   Kohantorabi, Marzieh
   Rezvani, Alireza
   Jamialahmadi, Tannaz
   Sahebkar, Amirhossein
   Moohebati, Mohsen
   Ghayour-Mobarhan, Majid
TI The correlation between indirect calorimetry data and the metabolic
   syndrome development in men and women
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Article
DE Metabolic syndrome; Indirect calorimetry; Resting metabolic rate;
   Macronutrient oxidation; Risk factors
ID ENERGY-EXPENDITURE; OXIDATIVE STRESS; TESTOSTERONE; PREVALENCE; OBESITY;
   FAT
AB ObjectivesTo investigate the indirect calorimetric findings in subjects with Metabolic Syndrome (MetS) compared to those without MetS and explore the potential parameters for predicting MetS in susceptible individuals.MethodsData was collected from a cross-sectional study conducted during the second phase of The Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) study, which involved 1,014 participants. The presence of MetS was determined using the National Cholesterol Education Program Adult Treatment Panel III criteria. The study involved taking anthropometric measurements, blood samples, and indirect calorimetry measurements.ResultsThe study showed significant differences in MetS criteria between the groups with and without MetS. According to the results in men, an increase in resting metabolic rate (RMR)/weight decreased the likelihood of developing MetS. However, an increase in protein oxidation raised the probability of developing MetS. Moreover, an increased RMR/weight or RMR/ body surface area (BSA) decreased the likelihood of developing MetS in women. Based on the logistic regression analysis, men with a higher RMR/Weight had a lower risk of developing MetS. Conversely, an increase in protein oxidation can increase the risk of MetS. However, women with higher RMR/Weight and RMR/BSA had a reduced risk of developing MetS.ConclusionsThese findings suggest that variations in RMR and macronutrient oxidations may play a role in the development of MetS. Assessing RMR and macronutrient oxidation through indirect calorimetry could potentially be used as predictive parameters for MetS. Further research is needed to better understand the underlying mechanisms and implications of these findings.
C1 [Roudi, Fatemeh; Saghi, Effat] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Iran.
   [Darroudi, Susan; Jamialahmadi, Tannaz; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Int UNESCO Ctr Hlth Related Basic Sci & Human Nutr, Mashhad, Iran.
   [Hosseini, Seyed Reza; Kohantorabi, Marzieh; Rezvani, Alireza] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
   [Moohebati, Mohsen] Mashhad Univ Med Sci, Fac Med, Cardiovasc Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences; Mashhad University of Medical Sciences
RP Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Int UNESCO Ctr Hlth Related Basic Sci & Human Nutr, Mashhad, Iran.; Moohebati, M (corresponding author), Mashhad Univ Med Sci, Fac Med, Cardiovasc Res Ctr, Mashhad, Iran.
EM Mouhebatim@mums.ac.ir; ghayourm@mums.ac.ir
RI Sahebkar, Amirhossein/B-5124-2018; Ghayour-Mobarhan,
   Majid/AAY-5963-2020; Rezvani, Alireza/AAN-8058-2021; mohebati,
   mohsen/AAR-2016-2021
FU Mashhad University of Medical Sciences
FX We hereby express our gratitude to all the study participants, the local
   partners, and who helped us conduct this research.
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Bhatti JS, 2017, BBA-MOL BASIS DIS, V1863, P1066, DOI 10.1016/j.bbadis.2016.11.010
   Bitz C, 2004, DIABETES CARE, V27, P2416, DOI 10.2337/diacare.27.10.2416
   Brand JS, 2011, INT J EPIDEMIOL, V40, P189, DOI 10.1093/ije/dyq158
   Buscemi S, 2007, CLIN NUTR, V26, P806, DOI 10.1016/j.clnu.2007.08.010
   Camera A, 2008, Minerva Med, V99, P307
   Dalle-Donne I, 2003, CLIN CHIM ACTA, V329, P23, DOI 10.1016/S0009-8981(03)00003-2
   de Ferranti S, 2008, CLIN CHEM, V54, P945, DOI 10.1373/clinchem.2007.100156
   Di Chiara T, 2012, J NUTR METAB, V2012, DOI 10.1155/2012/175245
   Farmanfarma KK, 2019, DIABETES METAB SYND, V13, P792, DOI 10.1016/j.dsx.2018.11.055
   Frasca D, 2017, FRONT IMMUNOL, V8, DOI [10.3389/fimmu.2017.01003, 10.3389/fimmu.2017.01745]
   Furukawa S., 2004, Journal of Clinical Investigation, V114, P1752, DOI 10.1172/JCI21625
   Ghayour-Mobarhan M, 2015, INT J PUBLIC HEALTH, V60, P561, DOI 10.1007/s00038-015-0679-6
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Henriksen EJ, 2011, FREE RADICAL BIO MED, V51, P993, DOI 10.1016/j.freeradbiomed.2010.12.005
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Kaur J., 2014, Medical Sciences, V2, P140, DOI DOI 10.3390/MEDSCI2030140
   Keane KN, 2015, CLIN SCI, V128, P723, DOI 10.1042/CS20140725
   Kolovou GD, 2007, AM J MED SCI, V333, P362, DOI 10.1097/MAJ.0b013e318065c3a1
   Leskinen T, 2013, AGE, V35, P1917, DOI 10.1007/s11357-012-9486-7
   Lorenzo C, 2007, DIABETES CARE, V30, P8, DOI 10.2337/dc06-1414
   Matsuzawa Y, 2006, FEBS LETT, V580, P2917, DOI 10.1016/j.febslet.2006.04.028
   Mittra S, 2008, DRUG DISCOV TODAY, V13, P211, DOI 10.1016/j.drudis.2008.01.006
   Montalcini T, 2014, NUTRIENTS, V6, P5560, DOI 10.3390/nu6125560
   Montalcini T, 2013, ENDOCRINE, V44, P380, DOI 10.1007/s12020-012-9845-2
   Muoio DM, 2008, DIABETES, V57, P1455, DOI 10.2337/db08-0281
   Muraleedharan V, 2010, THER ADV ENDOCRINOL, V1, P207, DOI 10.1177/2042018810390258
   Newsholme P, 2019, AM J PHYSIOL-CELL PH, V317, pC420, DOI 10.1152/ajpcell.00141.2019
   Oshima T, 2017, CLIN NUTR, V36, P651, DOI 10.1016/j.clnu.2016.06.010
   Pujia A, 2019, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00806
   Sjogren P, 2005, ARTERIOSCL THROM VAS, V25, P2580, DOI 10.1161/01.ATV.0000190675.08857.3d
   Soares MJ, 2018, EUR J CLIN NUTR, V72, P1208, DOI 10.1038/s41430-018-0220-0
   Soares M, 2022, METABOLITES, V12, DOI 10.3390/metabo12080722
   Touyz RM, 2020, CAN J CARDIOL, V36, P659, DOI 10.1016/j.cjca.2020.02.081
   Zhang HR, 2010, WORLD J CARDIOL, V2, P370, DOI 10.4330/wjc.v2.i11.370
   ZURLO F, 1990, AM J PHYSIOL, V259, pE650
NR 37
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD DEC 14
PY 2024
VL 24
IS 1
AR 1
DI 10.1007/s40200-024-01521-4
PG 6
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA P3W6O
UT WOS:001377256600001
PM 39686919
DA 2025-06-11
ER

PT J
AU Zhang, SY
   Xu, MY
   Shen, ZY
   Shang, CR
   Zhang, WX
   Chen, SY
   Liu, C
AF Zhang, Shiyao
   Xu, Mengyi
   Shen, Ziyue
   Shang, Changrui
   Zhang, Wenxiang
   Chen, Siyu
   Liu, Chang
TI Green light exposure aggravates high-fat diet feeding-induced hepatic
   steatosis and pancreatic dysfunction in male mice
SO ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
LA English
DT Article
DE Green light; Metabolic syndrome; Metabolite; Fatty liver; Hypoinsulinism
ID METABOLIC SYNDROME; OXIDATIVE STRESS; HIGH-SENSITIVITY; RECEPTORS;
   MELATONIN; OBESITY; NIGHT
AB The increased incidence of metabolic syndrome (MetS) has been demonstrated to be closely associated with external environments, such as unhealthy ambient light exposure. Of note, spectral distribution of the light functions as a critical determinant of light's pathophysiological effects. However, the effects of the lighting spectrum on metabolic homeostasis and the specific target organs remain elusive. To address this concern, we in this study high-fat diet (HFD)-fed obese mice with different spectra of the light, and divided them into white light (WL)-treated group, green light (GL)-treated group and blue light (BL)-treated group. We found that compared with BL-or WL-treated obese mice, animals exposed to GL showed worsened metabolic status, including increased body weight gain, impaired glucose tolerance/insulin sensitivity, increased levels of serum lipids, and decreased levels of serum insulin. At the organ level, GL exposure particularly exacerbated hepatic lipid accumulation and enlarged the islet volume. Taking advantages of metabolomics and transcriptomics analyses, we screened out taurocholic acid (TCA) and adenosine (AD) as two promising metabolites mediating the deleterious effects of GL on the liver and islets, respectively. In detail, GL aggravates HFD-induced lipid synthesis and gluconeogenesis in the liver via the reduction of TCA, while triggering inflammation and cellular dysfunction in islets via the induction of AD. Collectively, our findings confirmed that GL and the HFD have a synergistic effect in the induction of metabolic disorders. Data availability: All data supported the paper are present in the paper and/or the Supplementary Materials. The original datasets are also available from the corresponding author upon request.
C1 [Zhang, Shiyao; Xu, Mengyi; Shen, Ziyue; Shang, Changrui; Zhang, Wenxiang; Chen, Siyu; Liu, Chang] China Pharmaceut Univ, Sch Life Sci & Technol & Expt Platform Drug Chron, State Key Lab Nat Med, Nanjing, Jiangsu, Peoples R China.
   [Liu, Chang] Xinjiang Med Univ, Sch Pharm, Key Lab Act Components Nat Med & Drug Release Tec, Urumqi, Xinjiang, Peoples R China.
C3 China Pharmaceutical University; Xinjiang Medical University
RP Chen, SY; Liu, C (corresponding author), China Pharmaceut Univ, Sch Life Sci & Technol & Expt Platform Drug Chron, State Key Lab Nat Med, Nanjing, Jiangsu, Peoples R China.
EM siyuchen@cpu.edu.cn; changliu@cpu.edu.cn
RI Zhang, Shi-yao/GRO-1062-2022; Zhang, Wenxiang/HZK-0191-2023
OI Zhang, Shiyao/0000-0001-8871-0215
FU National Natural Science Foundation of China [92057112, 31771298,
   31800992, 81800512]; Natural Science Foundation of Jiangsu Province
   [BK20180554, BK20180577]; Project of State Key Laboratory of Natural
   Medicines, China Pharmaceutical University [SKLNMZZ202005]; Priority
   Academic Program Development of Jiangsu Higher Education Institutions
   (PAPD)
FX This work was financially supported by grants from the National Natural
   Science Foundation of China (92057112 and 31771298 to CL, 31800992 to
   SYC, 81800512 to WXZ), the Natural Science Foundation of Jiangsu
   Province (BK20180554 to SYC, BK20180577 to WXZ), the Project of State
   Key Laboratory of Natural Medicines, China Pharmaceutical University
   (SKLNMZZ202005 to CL), and the Priority Academic Program Development of
   Jiangsu Higher Education Institutions (PAPD, to CL and SYC).
CR Benedito-Silva AA, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0238772
   Blackburn Michael R, 2009, Handb Exp Pharmacol, P215, DOI 10.1007/978-3-540-89615-9_8
   Bumah VV, 2021, LASER MED SCI, V36, P1661, DOI 10.1007/s10103-021-03250-z
   Cajochen C, 2005, J CLIN ENDOCR METAB, V90, P1311, DOI 10.1210/jc.2004-0957
   Chen SY, 2018, FASEB J, V32, P1139, DOI [10.1096/fj.201700741RR, 10.1096/fj.201700741rr]
   Cheung IN, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0155601
   Dragsbæk K, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000004806
   Engin A, 2017, ADV EXP MED BIOL, V960, P1, DOI 10.1007/978-3-319-48382-5_1
   Fonken LK, 2014, ENDOCR REV, V35, P648, DOI 10.1210/er.2013-1051
   Fredholm BB, 2011, PHARMACOL REV, V63, P1, DOI 10.1124/pr.110.003285
   Gaudet P, 2011, BRIEF BIOINFORM, V12, P449, DOI 10.1093/bib/bbr042
   Gierach Marcin, 2014, ISRN Endocrinol, V2014, P514589, DOI 10.1155/2014/514589
   Guieu R, 2020, J CLIN MED, V9, DOI 10.3390/jcm9051366
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Lall GS, 2010, NEURON, V66, P417, DOI 10.1016/j.neuron.2010.04.037
   Liebel F, 2012, J INVEST DERMATOL, V132, P1901, DOI 10.1038/jid.2011.476
   Liu MM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071067
   Liu Xiao, 2019, Yi Chuan, V41, P365, DOI 10.16288/j.yczz.19-011
   Lockley SW, 2003, J CLIN ENDOCR METAB, V88, P4502, DOI 10.1210/jc.2003-030570
   Lu JL, 2017, J CLIN ENDOCR METAB, V102, P507, DOI 10.1210/jc.2016-2477
   Ma QQ, 2020, J AGR FOOD CHEM, V68, P4876, DOI 10.1021/acs.jafc.0c01023
   Martin L, 2021, PAIN MED, V22, P118, DOI 10.1093/pm/pnaa329
   Martin LF, 2021, CEPHALALGIA, V41, P135, DOI 10.1177/0333102420956711
   Masis-Vargas A, 2020, OBESITY, V28, pS114, DOI 10.1002/oby.22874
   Muthubharathi BC, 2021, MOL OMICS, V17, P210, DOI 10.1039/d0mo00176g
   Nakashima Y, 2017, FREE RADICAL BIO MED, V108, P300, DOI 10.1016/j.freeradbiomed.2017.03.010
   Ohtani M, 2013, GEN COMP ENDOCR, V187, P86, DOI 10.1016/j.ygcen.2013.02.011
   Ouyang XL, 2020, BIOMED PHARMACOTHER, V130, DOI 10.1016/j.biopha.2020.110577
   Pilorz V, 2016, PLOS BIOL, V14, DOI 10.1371/journal.pbio.1002482
   Riff R, 2017, J LEUKOCYTE BIOL, V102, P95, DOI 10.1189/jlb.3A0816-345RR
   Rumanova VS, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21155478
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Shi YJ, 2019, J CELL MOL MED, V23, P4464, DOI 10.1111/jcmm.14347
   Shukla SK, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-04469-z
   Slusher TM, 2015, NEW ENGL J MED, V373, P1115, DOI 10.1056/NEJMoa1501074
   Srisurapanont K, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0246172
   Sun Y, 2021, CELL REP, V34, DOI 10.1016/j.celrep.2020.108576
   Tan BE, 2012, FRONT BIOSCI-LANDMRK, V17, P2237, DOI 10.2741/4047
   Touitou Y, 2020, ENVIRON RES, V190, DOI 10.1016/j.envres.2020.109942
   Van Schaftingen E, 2002, BIOCHEM J, V362, P513, DOI 10.1042/0264-6021:3620513
   West AC, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00462-2
   Yang T, 2015, DIABETOLOGIA, V58, P1610, DOI 10.1007/s00125-015-3570-3
   Zhang JF, 2006, NATURE, V439, P340, DOI 10.1038/nature04368
   Zhang SY, 2019, ECOTOX ENVIRON SAFE, V178, P94, DOI 10.1016/j.ecoenv.2019.04.013
NR 44
TC 5
Z9 5
U1 2
U2 36
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0147-6513
EI 1090-2414
J9 ECOTOX ENVIRON SAFE
JI Ecotox. Environ. Safe.
PD DEC 1
PY 2021
VL 225
AR 112802
DI 10.1016/j.ecoenv.2021.112802
EA SEP 2021
PG 10
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA WC7EH
UT WOS:000704416800005
PM 34555719
OA gold
DA 2025-06-11
ER

PT J
AU Bacopoulou, F
   Landis, GN
   Palasz, A
   Tsitsika, A
   Vlachakis, D
   Tsarouhas, K
   Tsitsimpikou, C
   Stefanaki, C
   Kouretas, D
   Efthymiou, V
AF Bacopoulou, Flora
   Landis, Georgios N.
   Palasz, Artur
   Tsitsika, Artemis
   Vlachakis, Dimitrios
   Tsarouhas, Konstantinos
   Tsitsimpikou, Christina
   Stefanaki, Charikleia
   Kouretas, Dimitrios
   Efthymiou, Vasiliki
TI Identifying early abdominal obesity risk in adolescents by telemedicine:
   A cross-sectional study in Greece
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE School telemedicine; Abdominal obesity; Metabolic syndrome; Adolescents;
   Body composition; Waist circumference
ID BIOELECTRICAL-IMPEDANCE ANALYSIS; BODY-MASS INDEX; METABOLIC SYNDROME;
   OXIDATIVE STRESS; CHILDREN; ADIPOSITY; HEALTH; CHEMICALS; FAT;
   RELIABILITY
AB Obesity and thus, lipotoxicity, is a major health risk factor. Modern exposure to environmental chemicals has contributed significantly to the obesity epidemic. The purpose of this study was to assess, via telemedicine and using bioelectrical impedance analysis (BIA) in schools, the levels of adiposity and other body composition parameters of Greek adolescents in relation with their metabolic syndrome (MetS) characteristics.
   A representative sample (1575 adolescents, 14.4 +/- 1.7 years-old) of the Attica region population, underwent body composition assessment of fat mass (FM), fat-free mass (FFM), and total body water (TBW) and was evaluated for anthropometric and MetS characteristics.
   Males demonstrated higher FFM% and TBW% but lower FM% than females. Adolescents with abdominal obesity/MetS (n = 149/n = 40) demonstrated significantly (P < 0.001) higher body mass index (BMI 27.8 +/- 3.8 kg/m(2)/ 3 0.2 +/- 4.2 kg/m(2)) and FM (33.6 +/- 9.7%/35.0 +/- 10.5%) but significantly (P < 0.001) lower FFM (34.2 +/- 5.7%/33.8 +/- 6.2%) and TBW (45.6 +/- 6.7%/44.6 +/- 7.2%) than adolescents without abdominal obesity/MetS (BMI 20.9 +/- 2.8 kg/m(2)/ 21.3 +/- 3.2 kg/m(2); FM 19.2 +/- 6.9%/20.2 +/- 8.0%; FFM 41.3 +/- 4.4%/ 40.8 +/- 4.8%; TBW 55.5 +/- 4.8%/54.8 +/- 5.5%).
   Findings suggest that early "osteosarcopenic" elements of abdominal obesity/MetS may exist even in adolescence. The application of BIA, incorporated in the new approach methodology of telemedicine in schools, identified adolescents at risk for obesity complications.
C1 [Bacopoulou, Flora; Landis, Georgios N.; Stefanaki, Charikleia; Efthymiou, Vasiliki] Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, Ctr Adolescent Med, Sch Med, 1 Thivon St, Athens 11527, Greece.
   [Bacopoulou, Flora; Landis, Georgios N.; Stefanaki, Charikleia; Efthymiou, Vasiliki] Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, UNESCO Chair Adolescent Hlth Care, Dept Pediat 1,Sch Med, 1 Thivon St, Athens 11527, Greece.
   [Palasz, Artur] Med Univ Silesia, Sch Med Katowice, Dept Histol, Ul Medykow 18, PL-40752 Katowice, Poland.
   [Tsitsika, Artemis] Natl & Kapodistrian Univ Athens, P&A Kyriakou Childrens Hosp, Sch Med, Dept Pediat 2,Adolescent Hlth Unit, Thivon & Levadeias St, Athens 11527, Greece.
   [Vlachakis, Dimitrios] Agr Univ Athens, Sch Food Biotechnol & Dev, Dept Biotechnol, Lab Genet, Athens, Greece.
   [Vlachakis, Dimitrios] Kings Coll London, Fac Nat & Math Sci, Dept Informat, London, England.
   [Tsarouhas, Konstantinos] Univ Hosp Larissa, Dept Cardiol, Larisa, Greece.
   [Tsitsimpikou, Christina] Gen Chem State Lab Greece, 16 An Tsocha St, Athens 11521, Greece.
   [Kouretas, Dimitrios] Univ Thessaly, Dept Biochem & Biotechnol, Larisa, Greece.
C3 Athens Medical School; National & Kapodistrian University of Athens; The
   Aghia Sophia Children's Hospital; National & Kapodistrian University of
   Athens; Athens Medical School; The Aghia Sophia Children's Hospital;
   Medical University of Silesia; Athens Medical School; National &
   Kapodistrian University of Athens; Agricultural University of Athens;
   University of London; King's College London; General University Hospital
   of Larissa; University of Thessaly
RP Bacopoulou, F (corresponding author), Natl & Kapodistrian Univ Athens, Sch Med, Ctr Adolescent Med, 1 Thivon St, Athens 11527, Greece.; Bacopoulou, F (corresponding author), Natl & Kapodistrian Univ Athens, Sch Med, UNESCO Chair Adolescent Hlth Care, Dept Pediat 1, 1 Thivon St, Athens 11527, Greece.; Bacopoulou, F (corresponding author), Aghia Sophia Childrens Hosp, Ctr Adolescent Med, 1 Thivon St, Athens 11527, Greece.
EM fbacopoulou@med.uoa.gr; georgioslandis@yahoo.co.uk; apalasz@sum.edu.pl;
   atsitsik@med.uoa.gr; dimvl@aua.gr; ktsarouhas14@yahoo.gr;
   chtsitsi@yahoo.com; cstefanaki@gmail.com; dkouret@uth.gr;
   vikimiou2003@yahoo.gr
RI KOURETAS, DEMETRIOS/ABE-8519-2020; Bacopoulou, Flora/AAH-1218-2019;
   Stefanaki, Charikleia/G-6653-2012; Efthymiou, Vasiliki/GWC-7978-2022;
   Vlachakis, Dimitrios/O-4323-2018; Tsarouhas, Konstantinos/H-5793-2019
OI Vlachakis, Dimitrios/0000-0003-1823-6102; Stefanaki,
   Charikleia/0000-0003-1634-701X; Tsarouhas,
   Konstantinos/0000-0003-2651-3579
FU European Union [MIS 371406]
FX The program was funded by the European Union in the context of the
   National Strategic Reference Framework 2007-2013 (program code MIS
   371406). The funding source had no involvement in the study design; in
   the collection, analysis, and interpretation of data; in the writing of
   the manuscript; and in the decision to submit the paper for publication.
CR Apatsidou M, 2018, BIOMED REP, V8, P160, DOI 10.3892/br.2018.1037
   Ayvaz DNÇ, 2011, TURK J MED SCI, V41, P267, DOI 10.3906/sag-0909-254
   Bacopoulou F, 2019, EUR J CLIN INVEST, V49, DOI 10.1111/eci.13075
   Bacopoulou F, 2017, EUR J CLIN INVEST, V47, P447, DOI 10.1111/eci.12760
   Bacopoulou F, 2015, BMC PEDIATR, V15, DOI 10.1186/s12887-015-0366-z
   Baltzis D, 2018, EXP THER MED, V15, P3420, DOI 10.3892/etm.2018.5798
   BERNSTEIN RS, 1983, AM J CLIN NUTR, V37, P595, DOI 10.1093/ajcn/37.4.595
   Bokor S, 2008, INT J PEDIATR OBES, V3, P3, DOI 10.1080/17477160802404509
   Botton J, 2017, ANN ENDOCRINOL-PARIS, V78, P108, DOI 10.1016/j.ando.2017.04.009
   Choi J, 2017, INT J HYG ENVIR HEAL, V220, P282, DOI 10.1016/j.ijheh.2016.12.006
   Egusquiza RJ, 2020, ENDOCRINOLOGY, V161, DOI 10.1210/endocr/bqaa024
   Engin AB, 2018, FOOD CHEM TOXICOL, V112, P157, DOI 10.1016/j.fct.2017.12.055
   Engin AB, 2017, ADV EXP MED BIOL, V960, P197, DOI 10.1007/978-3-319-48382-5_8
   Estadella D, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/137579
   Gaforio JJ, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092039
   Galli-Tsinopoulou A, 2009, J DIABETES, V1, P36, DOI 10.1111/j.1753-0407.2008.00002.x
   GARROW JS, 1985, LANCET, V1, P670
   Georgiadis N, 2018, TOXICOL APPL PHARM, V353, P1, DOI 10.1016/j.taap.2018.06.004
   Geronikolou SA, 2017, ADV EXP MED BIOL, V987, P291, DOI 10.1007/978-3-319-57379-3_26
   Gómez-Hernández A, 2016, INT J ENDOCRINOL, V2016, DOI 10.1155/2016/1216783
   Gore AC, 2015, ENDOCR REV, V36, pE1, DOI 10.1210/er.2015-1010
   Grammatikopoulou MG, 2014, CLIN OBES, V4, P303, DOI 10.1111/cob.12070
   Grammatikopoulou MG, 2018, ETHNIC HEALTH, V23, P221, DOI 10.1080/13557858.2016.1258043
   Hassapidou M, 2006, OBESITY, V14, P855, DOI 10.1038/oby.2006.99
   Heindel JJ, 2019, ANNU REV PHARMACOL, V59, P89, DOI 10.1146/annurev-pharmtox-010818-021304
   Ilich JZ, 2014, AGEING RES REV, V15, P51, DOI 10.1016/j.arr.2014.02.007
   Javed A, 2015, PEDIATR OBES, V10, P234, DOI 10.1111/ijpo.242
   Joint F.A.O.W.H.O.U.N.U.E.C.o.E., 1985, EN PROT REQ REP JOIN
   Katsikantami I, 2016, ENVIRON INT, V97, P212, DOI 10.1016/j.envint.2016.09.013
   Kelishadi Roya, 2013, J Environ Public Health, V2013, P896789, DOI 10.1155/2013/896789
   Kelly O.J., 2019, NUTRIENTS, V11
   Kettaneh A, 2005, DIABETES METAB, V31, P534, DOI 10.1016/S1262-3636(07)70228-8
   Kollias A, 2013, OBESITY, V21, P1013, DOI 10.1002/oby.20194
   Koutedakis Y, 2005, MED SCI SPORT EXER, V37, P2070, DOI 10.1249/01.mss.0000178099.80388.15
   Kumar AS, 2019, DIABETES METAB SYND, V13, P344, DOI 10.1016/j.dsx.2018.10.005
   Kyle UG, 2004, CLIN NUTR, V23, P1226, DOI 10.1016/j.clnu.2004.06.004
   Laurens C, 2016, SCI REP-UK, V6, DOI 10.1038/srep38310
   Lazzer S, 2003, BRIT J NUTR, V90, P987, DOI 10.1079/BJN2003983
   Lefranc C, 2018, J ENDOCRINOL, V238, pR143, DOI 10.1530/JOE-18-0163
   Loomba-Albrecht LA, 2009, CURR OPIN ENDOCRINOL, V16, P10, DOI 10.1097/MED.0b013e328320d54c
   Martin ASG, 2006, AM J CLIN NUTR, V83, p461S, DOI 10.1093/ajcn/83.2.461s
   McMurray F, 2016, OBESITY, V24, P2301, DOI 10.1002/oby.21654
   Moreno LA, 2006, EUR J CLIN NUTR, V60, P191, DOI 10.1038/sj.ejcn.1602285
   National Institutes of Health, 1994, BIOEL IMP AN BOD COM
   Ntalla I, 2014, PUBLIC HEALTH NUTR, V17, P561, DOI 10.1017/S1368980013000074
   Papandreou C, 2012, SLEEP BREATH, V16, P873, DOI 10.1007/s11325-011-0589-7
   Petrakis D, 2017, INT J ENV RES PUB HE, V14, DOI 10.3390/ijerph14101282
   Pi-Sunyer FX, 2002, OBES SURG, V12, p6S, DOI 10.1007/BF03342140
   Primeau V, 2011, INT J OBESITY, V35, P971, DOI 10.1038/ijo.2010.216
   Puttabyatappa M, 2020, J ENDOCRINOL, V245, pR23, DOI 10.1530/JOE-20-0044
   Ramalingam L, 2017, BBA-MOL BASIS DIS, V1863, P1106, DOI 10.1016/j.bbadis.2016.07.019
   Rentoukas E, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035739
   Sarwer DB, 2020, AM PSYCHOL, V75, P135, DOI 10.1037/amp0000610
   Siddarth D, 2013, J INVEST MED, V61, P1039, DOI 10.2310/JIM.0b013e31829c39d0
   Stefanaki C, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17082688
   Stefanaki C, 2018, HORM-INT J ENDOCRINO, V17, P33, DOI 10.1007/s42000-018-0023-7
   Stefanaki C, 2016, EUR J CLIN INVEST, V46, P767, DOI 10.1111/eci.12659
   Talma H, 2013, OBES REV, V14, P895, DOI 10.1111/obr.12061
   Trasande L, 2020, EUR J EPIDEMIOL, V35, P305, DOI 10.1007/s10654-020-00623-6
   Tsarouhas A, 2017, MOL MED REP, V15, P2195, DOI 10.3892/mmr.2017.6221
   Tsatsakis AM, 2017, HUM EXP TOXICOL, V36, P554, DOI 10.1177/0960327116681652
   Tsatsakis AM, 2016, FOOD CHEM TOXICOL, V96, P174, DOI 10.1016/j.fct.2016.08.011
   Vassilopoulou Loukia, 2017, Adv Exp Med Biol, V960, P81, DOI 10.1007/978-3-319-48382-5_4
   Walter-Kroker A, 2011, NUTR J, V10, DOI 10.1186/1475-2891-10-35
   Wells JCK, 2002, INT J OBESITY, V26, P1323, DOI 10.1038/sj.ijo.0802077
   Zimmet P, 2007, PEDIATR DIABETES, V8, P299, DOI 10.1111/j.1399-5448.2007.00271.x
NR 66
TC 7
Z9 7
U1 0
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD OCT
PY 2020
VL 144
AR 111532
DI 10.1016/j.fct.2020.111532
PG 8
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA NK6AX
UT WOS:000566815000002
PM 32645466
DA 2025-06-11
ER

PT J
AU Poniedzialek-Czajkowska, E
   Mierzynski, R
   Kimber-Trojnar, Z
   Leszczynska-Gorzelak, B
   Oleszczuk, J
AF Poniedzialek-Czajkowska, Elzbieta
   Mierzynski, Radzislaw
   Kimber-Trojnar, Zaneta
   Leszczynska-Gorzelak, Bozena
   Oleszczuk, Jan
TI Polyunsaturated Fatty Acids in Pregnancy and Metabolic Syndrome: A
   Review
SO CURRENT PHARMACEUTICAL BIOTECHNOLOGY
LA English
DT Review
DE DHA; EPA; gestational diabetes mellitus; metabolic syndrome;
   polyunsaturated fatty acids; pregnancy; preeclampsia
ID FISH-OIL SUPPLEMENTATION; NF-KAPPA-B; ACTIVATED PROTEIN-KINASE;
   ALPHA-LINOLENIC ACID; BODY-MASS INDEX; INSULIN-RESISTANCE;
   EICOSAPENTAENOIC ACID; DOCOSAHEXAENOIC ACID; MATERNAL OBESITY; OXIDATIVE
   STRESS
AB This review presents available evidence for possible application of n-3 long chain polyunsaturated fatty acids (PUFAs) in pregnant obese women with metabolic syndrome (MS) and focuses on prophylaxis of pregnancy complications associated with MS such as gestational hypertension, preeclampsia and gestational diabetes. Dietary supplementation with n-3 PUFAs has recently become popular and their adequate intake during pregnancy and early childhood is of clinical importance. The results of experimental and epidemiological investigations reveal that n-3 PUFAs, especially alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), may decrease the risk of cardiovascular diseases. It is believed that n-3 PUFAs affect a multitude of molecular pathways, involving regulation of gene expression, alteration of physical and chemical properties of cellular membranes and modulation of membrane channels and proteins. A large body of evidence focuses on anti-inflammatory properties of PUFAs which seem to be fundamental in prevention and reversing of insulin resistance, atherogenic dyslipidemia, hypertension, thromboembolism and in improving vascular function. Despite the potential PUFAs benefits of decreasing insulin resistance, their application in order to prevent preeclampsia, gestational hypertension and gestational diabetes mellitus in pregnant women with MS has not yet been established. Numerous reports have revealed that appropriate fetal development, including neuronal, retinal and immune function depends on EPA and DHA which are crucial also for prevention of preterm birth. Thus the supplementation with EPA and DHA is highly recommended during pregnancy although the optimal dosing and treatment strategies still need to be determined.
C1 [Poniedzialek-Czajkowska, Elzbieta; Mierzynski, Radzislaw; Kimber-Trojnar, Zaneta; Leszczynska-Gorzelak, Bozena; Oleszczuk, Jan] Med Univ Lublin, Dept Obstet & Perinatol, PL-20954 Lublin, Poland.
C3 Medical University of Lublin
RP Poniedzialek-Czajkowska, E (corresponding author), Med Univ Lublin, Dept Obstet & Perinatol, Ul Jaczewskiego 8, PL-20954 Lublin, Poland.
EM elzbietapc@yahoo.com
OI Kimber-Trojnar, Zaneta/0000-0001-7295-0409
CR Aarsetoey H, 2011, LIPIDS, V46, P151, DOI 10.1007/s11745-010-3511-3
   Abdollahi M, 2003, THROMB HAEMOSTASIS, V89, P493, DOI 10.1055/s-0037-1613379
   Agostoni C, 2010, EARLY HUM DEV, V86, pS3, DOI 10.1016/j.earlhumdev.2010.01.003
   AL MDM, 1995, BRIT J NUTR, V74, P55, DOI 10.1079/BJN19950106
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Anderson BM, 2009, LIPIDS HEALTH DIS, V8, DOI 10.1186/1476-511X-8-33
   [Anonymous], 2003, WHO Technical Report Series no. 916, P89
   [Anonymous], 2010, GINEKOL POL, V81, P467
   [Anonymous], 2004, WHAT YOU NEED KNOW M
   [Anonymous], 2010, DIET GUID AM 2010
   Baggia S, 1996, J SOC GYNECOL INVEST, V3, P121, DOI 10.1177/107155769600300304
   Balk EM, 2006, ATHEROSCLEROSIS, V189, P19, DOI 10.1016/j.atherosclerosis.2006.02.012
   Banga A, 2009, AM J PHYSIOL-ENDOC M, V296, pE480, DOI 10.1152/ajpendo.90892.2008
   Barton JR, 2008, OBSTET GYNECOL, V112, P359, DOI 10.1097/AOG.0b013e3181801d56
   Bhat T, 2013, EXPERT REV CARDIOVAS, V11, P55, DOI [10.1586/erc.12.159, 10.1586/ERC.12.159]
   Birdsall KM, 2009, INT J CLIN PRACT, V63, P494, DOI 10.1111/j.1742-1241.2008.01910.x
   Biron-Shental T, 2007, AM J OBSTET GYNECOL, V197, DOI 10.1016/j.ajog.2007.03.066
   Blasbalg TL, 2011, AM J CLIN NUTR, V93, P950, DOI 10.3945/ajcn.110.006643
   BLAUSTEIN MP, 1991, HYPERTENSION, V18, pS184
   Brenner RR, 2003, PROSTAG LEUKOTR ESS, V68, P151, DOI 10.1016/S0952-3278(02)00265-X
   Brooks GC, 2010, AM J CARDIOL, V106, P56, DOI 10.1016/j.amjcard.2010.02.017
   Buchanan TA, 2005, J CLIN INVEST, V115, P485, DOI 10.1172/JCI200524531
   Burdge GC, 2005, REPROD NUTR DEV, V45, P581, DOI 10.1051/rnd:2005047
   Burdge GC, 2002, BRIT J NUTR, V88, P411, DOI 10.1079/BJN2002689
   CAMPBELL FM, 1995, BIOCHEM BIOPH RES CO, V209, P1011, DOI 10.1006/bbrc.1995.1598
   Carey RM, 2003, ENDOCR REV, V24, P261, DOI 10.1210/er.2003-0001
   Carmina E, 1999, J CLIN ENDOCR METAB, V84, P1897, DOI 10.1210/jc.84.6.1897
   Catalano PM, 2010, REPRODUCTION, V140, P365, DOI 10.1530/REP-10-0088
   CATALANO PM, 1991, AM J OBSTET GYNECOL, V165, P1667, DOI 10.1016/0002-9378(91)90012-G
   Catalano PM, 2003, AM J OBSTET GYNECOL, V189, P1698, DOI 10.1016/S0002-9378(03)00828-7
   Catalano PM, 2002, AM J PHYSIOL-ENDOC M, V282, pE522, DOI 10.1152/ajpendo.00124.2001
   Chan DC, 2002, DIABETES, V51, P2377, DOI 10.2337/diabetes.51.8.2377
   Childs CE, 2008, P NUTR SOC, V67, P19, DOI 10.1017/S0029665108005983
   CHIN JPF, 1995, CLIN EXP PHARMACOL P, V22, P71, DOI 10.1111/j.1440-1681.1995.tb01959.x
   Codde J P, 1984, J Hypertens, V2, P265
   CRAWFORD MA, 1992, NUTR REV, V50, P3
   Cunnane SC, 2003, PROG LIPID RES, V42, P544, DOI 10.1016/S0163-7827(03)00038-9
   Dabelea D, 2005, DIABETES CARE, V28, P579, DOI 10.2337/diacare.28.3.579
   DAHLGREN E, 1994, FERTIL STERIL, V61, P455
   Denys A, 2005, J LIPID RES, V46, P752, DOI 10.1194/jlr.M400444-JLR200
   Domingo JL, 2007, ENVIRON INT, V33, P397, DOI 10.1016/j.envint.2006.12.004
   Dooper MMBW, 2002, IMMUNOLOGY, V107, P152, DOI 10.1046/j.1365-2567.2002.01474.x
   Dunstan JA, 2008, ARCH DIS CHILD-FETAL, V93, pF45, DOI 10.1136/adc.2006.099085
   Dunstan JA, 2004, EUR J CLIN NUTR, V58, P429, DOI 10.1038/sj.ejcn.1601825
   Dupasquier CMC, 2006, AM J PHYSIOL-HEART C, V291, pH2987, DOI 10.1152/ajpheart.01179.2005
   Dutta-Roy AK, 2000, AM J CLIN NUTR, V71, p315S, DOI 10.1093/ajcn/71.1.315s
   Elias SL, 2001, AM J CLIN NUTR, V73, P807
   Endo S, 2006, GYNECOL ENDOCRINOL, V22, P343, DOI 10.1080/09513590600724836
   Engler M B, 1994, J Cardiovasc Nurs, V8, P53
   Engler M B, 1994, J Cardiovasc Risk, V1, P75, DOI 10.1097/00043798-199406000-00012
   FESKENS EJM, 1991, DIABETES CARE, V14, P935, DOI 10.2337/diacare.14.11.935
   Figueras M, 2011, OBESITY, V19, P362, DOI 10.1038/oby.2010.194
   Flachs P, 2006, DIABETOLOGIA, V49, P394, DOI 10.1007/s00125-005-0053-y
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Freeman MP, 2006, PROSTAG LEUKOTR ESS, V75, P291, DOI 10.1016/j.plefa.2006.07.007
   Furuhjelm C, 2009, ACTA PAEDIATR, V98, P1461, DOI 10.1111/j.1651-2227.2009.01355.x
   Gajos G., 2010, J Am Coll Cardiol, V55, P1671
   Geleijnse JM, 2002, J HYPERTENS, V20, P1493, DOI 10.1097/00004872-200208000-00010
   Gerrard J, 1991, Arctic Med Res, VSuppl, P763
   Goldfine AB, 2008, CTS-CLIN TRANSL SCI, V1, P36, DOI 10.1111/j.1752-8062.2008.00026.x
   Grundt H, 2003, EUR J CLIN NUTR, V57, P793, DOI 10.1038/sj.ejcn.1601730
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Guallar E, 2002, NEW ENGL J MED, V347, P1747, DOI 10.1056/NEJMoa020157
   Guelinckx I, 2008, OBES REV, V9, P140, DOI 10.1111/j.1467-789X.2007.00464.x
   Hallahan B, 2005, BRIT J PSYCHIAT, V186, P275, DOI 10.1192/bjp.186.4.275
   HALLAQ H, 1992, P NATL ACAD SCI USA, V89, P1760, DOI 10.1073/pnas.89.5.1760
   Harper M, 2010, OBSTET GYNECOL, V115, P234, DOI 10.1097/AOG.0b013e3181cbd60e
   Harris WS, 2007, AM J CARDIOL, V99, p44C, DOI 10.1016/j.amjcard.2006.11.021
   Harris WS, 2006, CURR OPIN LIPIDOL, V17, P387, DOI 10.1097/01.mol.0000236363.63840.16
   Hartweg J, 2008, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003205.pub2
   Helland IB, 1998, EUR J CLIN NUTR, V52, P839, DOI 10.1038/sj.ejcn.1600656
   Helland IB, 2003, PEDIATRICS, V111, DOI 10.1542/peds.111.1.e39
   Helland IB, 2008, PEDIATRICS, V122, pE472, DOI 10.1542/peds.2007-2762
   Hendler I, 2005, AM J OBSTET GYNECOL, V193, P979, DOI 10.1016/j.ajog.2005.06.041
   Hillier TA, 2007, DIABETES CARE, V30, P2287, DOI 10.2337/dc06-2361
   Homko CJ, 2003, DIABETES, V52, P487, DOI 10.2337/diabetes.52.2.487
   Huber J, 2007, INT J OBESITY, V31, P1004, DOI 10.1038/sj.ijo.0803511
   Innis SM, 2001, J NUTR, V131, P118, DOI 10.1093/jn/131.1.118
   *ISSFAL, 2004, REC INT POL FATT AC
   Itoh M, 2007, ARTERIOSCL THROM VAS, V27, P1918, DOI 10.1161/ATVBAHA.106.136853
   Jacobson TA, 2008, AM J CLIN NUTR, V87, p1981S, DOI 10.1093/ajcn/87.6.1981S
   James M, 2010, P NUTR SOC, V69, P316, DOI 10.1017/S0029665110001564
   Judge MP, 2007, AM J CLIN NUTR, V85, P1572, DOI 10.1093/ajcn/85.6.1572
   Kaaja R, 1999, METABOLISM, V48, P892, DOI 10.1016/S0026-0495(99)90225-1
   Kalupahana NS, 2011, ADV NUTR, V2, P304, DOI 10.3945/an.111.000505
   Kalupahana NS, 2012, MOL ASPECTS MED, V33, P26, DOI 10.1016/j.mam.2011.10.011
   Kapoor R, 2006, CURR PHARM BIOTECHNO, V7, P531, DOI 10.2174/138920106779116874
   Kelly RW, 2002, J REPROD IMMUNOL, V57, P217, DOI 10.1016/S0165-0378(02)00007-4
   Kidd PM, 2007, ALTERN MED REV, V12, P207
   Kim F, 2007, CIRC RES, V100, P1589, DOI 10.1161/CIRCRESAHA.106.142851
   Kinoshita T, 2006, GYNECOL OBSTET INVES, V61, P115, DOI 10.1159/000089456
   Kirwan JP, 2002, DIABETES, V51, P2207, DOI 10.2337/diabetes.51.7.2207
   Kitson AP, 2010, LIPIDS, V45, P209, DOI 10.1007/s11745-010-3391-6
   Koletzko B, 2007, BRIT J NUTR, V98, P873, DOI 10.1017/S0007114507764747
   Krauss-Etschmann S, 2008, J ALLERGY CLIN IMMUN, V121, P464, DOI 10.1016/j.jaci.2007.09.018
   Krebs JD, 2006, INT J OBESITY, V30, P1535, DOI 10.1038/sj.ijo.0803309
   Kris-Etherton PM, 2002, CIRCULATION, V106, P2747, DOI 10.1161/01.CIR.0000038493.65177.94
   Kristensen SD, 2001, LIPIDS, V36, pS79, DOI 10.1007/s11745-001-0671-2
   Kuda O, 2009, DIABETOLOGIA, V52, P941, DOI 10.1007/s00125-009-1305-z
   Kulkarni AV, 2011, PROSTAG LEUKOTR ESS, V84, P51, DOI 10.1016/j.plefa.2010.09.005
   Kumar A, 2004, J MOL MED, V82, P434, DOI 10.1007/s00109-004-0555-y
   Kumar KV, 1997, P SOC EXP BIOL MED, V214, P374, DOI 10.3181/00379727-214-44106
   Lai YHL, 2013, CLIN NUTR, V32, P966, DOI 10.1016/j.clnu.2013.05.002
   Lam C, 2005, HYPERTENSION, V46, P1077, DOI 10.1161/01.HYP.0000187899.34379.b0
   Lamaziere A, 2013, PROSTAG LEUKOTR ESS, V88, P149, DOI 10.1016/j.plefa.2012.12.001
   LARDINOIS CK, 1991, J AM COLL NUTR, V10, P340
   Larsson SC, 2004, AM J CLIN NUTR, V79, P935
   Lau DCW, 2005, AM J PHYSIOL-HEART C, V288, pH2031, DOI 10.1152/ajpheart.01058.2004
   Lee JH, 2009, NAT REV CARDIOL, V6, P753, DOI 10.1038/nrcardio.2009.188
   Lee JY, 2004, J BIOL CHEM, V279, P16971, DOI 10.1074/jbc.M312990200
   Legrand P, 2010, LIPIDS, V45, P11, DOI 10.1007/s11745-009-3376-5
   Lev EI, 2010, J AM COLL CARDIOL, V55, P114, DOI 10.1016/j.jacc.2009.08.039
   Li H, 2005, KIDNEY INT, V67, P867, DOI 10.1111/j.1523-1755.2005.00151.x
   Li QR, 2007, ARCH BIOCHEM BIOPHYS, V466, P250, DOI 10.1016/j.abb.2007.06.023
   Lichtenstein AH, 2005, THROMB RES, V117, P71, DOI 10.1016/j.thromres.2005.04.013
   Lloyd-Jones DM, 2010, CIRCULATION, V121, P586, DOI 10.1161/CIRCULATIONAHA.109.192703
   Llurba E, 2005, METABOLISM, V54, P1504, DOI 10.1016/j.metabol.2005.05.017
   Lorente-Cebrián S, 2009, CLIN SCI, V117, P243, DOI 10.1042/CS20090020
   Makrides M, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003402.pub2
   Makrides M, 2010, JAMA-J AM MED ASSOC, V304, P1675, DOI 10.1001/jama.2010.1507
   Mazaki-Tovi S, 2009, J PERINAT MED, V37, P349, DOI 10.1515/JPM.2009.085
   Mehendale S, 2008, INT J GYNECOL OBSTET, V100, P234, DOI 10.1016/j.ijgo.2007.08.011
   Metzger BE, 2007, DIABETES CARE, V30, pS251, DOI 10.2337/dc07-s225
   Minich DM, 2008, NUTR REV, V66, P429, DOI 10.1111/j.1753-4887.2008.00075.x
   Montgomery C, 2003, BRIT J NUTR, V90, P135, DOI 10.1079/BJN2003888
   Montori VM, 2000, DIABETES CARE, V23, P1407, DOI 10.2337/diacare.23.9.1407
   Mori TA, 1999, AM J CLIN NUTR, V70, P817
   Nelson SM, 2010, HUM REPROD UPDATE, V16, P255, DOI 10.1093/humupd/dmp050
   Neschen S, 2007, DIABETES, V56, P1034, DOI 10.2337/db06-1206
   Nestel P, 2002, AM J CLIN NUTR, V76, P326, DOI 10.1093/ajcn/76.2.326
   O'Brien TE, 2003, EPIDEMIOLOGY, V14, P368, DOI 10.1097/00001648-200305000-00020
   O'Donnell Valerie B., 2009, V462, P5, DOI 10.1007/978-1-60327-115-8_1
   Oh DY, 2010, CELL, V142, P687, DOI 10.1016/j.cell.2010.07.041
   Okereke NC, 2004, AM J PHYSIOL-ENDOC M, V287, pE472, DOI 10.1152/ajpendo.00589.2003
   Olafsdottir AS, 2006, BJOG-INT J OBSTET GY, V113, P301, DOI 10.1111/j.1471-0528.2006.00826.x
   Olefsky JM, 2010, ANNU REV PHYSIOL, V72, P219, DOI 10.1146/annurev-physiol-021909-135846
   Olsen SF, 2000, BRIT J OBSTET GYNAEC, V107, P382, DOI 10.1111/j.1471-0528.2000.tb13235.x
   Pagán A, 2013, AM J PHYSIOL-ENDOC M, V305, pE826, DOI 10.1152/ajpendo.00291.2013
   Pérez-Echarri N, 2009, BRIT J NUTR, V101, P1059, DOI 10.1017/S0007114508048307
   Perkins ND, 2007, NAT REV MOL CELL BIO, V8, P49, DOI 10.1038/nrm2083
   Pollard JK, 1996, AM J OBSTET GYNECOL, V174, P682, DOI 10.1016/S0002-9378(96)70450-7
   Poudyal H, 2011, PROG LIPID RES, V50, P372, DOI 10.1016/j.plipres.2011.06.003
   Radesky JS, 2008, PAEDIATR PERINAT EP, V22, P47, DOI 10.1111/j.1365-3016.2007.00899.x
   Rafraf M, 2012, J AM COLL NUTR, V31, P361, DOI 10.1080/07315724.2012.10720443
   Rajasingam D, 2009, AM J OBSTET GYNECOL, V200, DOI 10.1016/j.ajog.2008.10.047
   Ramakers JD, 2007, LIPIDS, V42, P687, DOI 10.1007/s11745-007-3071-3
   Ramakrishnan U, 2010, FOOD NUTR BULL, V31, pS108, DOI 10.1177/15648265100312S203
   Ramsay JE, 2004, J HYPERTENS, V22, P2177, DOI 10.1097/00004872-200411000-00021
   Ramsay JE, 2002, J CLIN ENDOCR METAB, V87, P4231, DOI 10.1210/jc.2002-020311
   Rasouli N, 2008, J CLIN ENDOCR METAB, V93, pS64, DOI 10.1210/jc.2008-1613
   Ratnayake WMN, 2009, ANN NUTR METAB, V55, P8, DOI 10.1159/000228994
   Redman CW, 2005, SCIENCE, V308, P1592, DOI 10.1126/science.1111726
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Robinson LE, 2013, LIPIDS, V48, P319, DOI 10.1007/s11745-013-3774-6
   Romeo GR, 2012, ARTERIOSCL THROM VAS, V32, P1771, DOI 10.1161/ATVBAHA.111.241869
   Sánchez-Vera I, 2007, METABOLISM, V56, P1527, DOI 10.1016/j.metabol.2007.06.020
   Sary AA, 2012, B ENVIRON CONTAM TOX, V88, P162, DOI 10.1007/s00128-011-0510-x
   Sattar N, 2002, BMJ-BRIT MED J, V325, P157, DOI 10.1136/bmj.325.7356.157
   Seki H, 2009, PROSTAG OTH LIPID M, V89, P126, DOI 10.1016/j.prostaglandins.2009.03.002
   Serhan CN, 2008, NAT REV IMMUNOL, V8, P349, DOI 10.1038/nri2294
   Serhan CN, 2009, J EXP MED, V206, P15, DOI 10.1084/jem.20081880
   Serhan CN, 2005, PHARMACOL THERAPEUT, V105, P7, DOI 10.1016/j.pharmthera.2004.09.002
   Serini S, 2011, CHEM RES TOXICOL, V24, P2093, DOI 10.1021/tx200314p
   Sigal LH, 2006, JCR-J CLIN RHEUMATOL, V12, P207, DOI 10.1097/01.rhu.0000231385.94784.e4
   Simopoulos A P, 2003, Forum Nutr, V56, P67
   Simopoulos AP, 2003, WORLD REV NUTR DIET, V92, P1
   Simopoulos AP, 2008, EXP BIOL MED, V233, P674, DOI 10.3181/0711-MR-311
   Sinha S, 2004, J BIOL CHEM, V279, P41294, DOI 10.1074/jbc.M406514200
   Sivan E, 1997, DIABETES CARE, V20, P1470, DOI 10.2337/diacare.20.9.1470
   Sontrop J, 2006, PREV MED, V42, P4, DOI 10.1016/j.ypmed.2005.11.005
   SORENSEN JD, 1993, AM J OBSTET GYNECOL, V168, P915, DOI 10.1016/S0002-9378(12)90845-5
   Su HM, 2001, J LIPID RES, V42, P581
   Suchankova G, 2005, BIOCHEM BIOPH RES CO, V326, P851, DOI 10.1016/j.bbrc.2004.11.114
   Svegliati-Baroni G, 2006, AM J PATHOL, V169, P846, DOI 10.2353/ajpath.2006.050953
   Talom RT, 1999, LIFE SCI, V64, P1415, DOI 10.1016/S0024-3205(99)00075-2
   Taneja A, 2012, ANNU REV FOOD SCI T, V3, P105, DOI 10.1146/annurev-food-022811-101130
   Tayyebi-Khosroshahi H, 2010, IRAN J KIDNEY DIS, V4, P322
   Trellakis S, 2012, OBESITY FACTS, V5, P305, DOI 10.1159/000339452
   Tull SP, 2009, PLOS BIOL, V7, DOI 10.1371/journal.pbio.1000177
   Van de Werf F, 2003, EUR HEART J, V24, P28, DOI 10.1016/S0195-668X(02)00618-8
   van Schothorst EM, 2009, BMC GENOMICS, V10, DOI 10.1186/1471-2164-10-110
   Vayá A, 2011, METAB SYNDR RELAT D, V9, P197, DOI 10.1089/met.2010.0117
   Vignais PV, 2002, CELL MOL LIFE SCI, V59, P1428, DOI 10.1007/s00018-002-8520-9
   Villamor E, 2006, LANCET, V368, P1164, DOI 10.1016/S0140-6736(06)69473-7
   Wang CZ, 2004, GEOPHYS MONOGR SER, V147, P1
   Wang Y, 2000, DIABETES CARE, V23, P460, DOI 10.2337/diacare.23.4.460
   Weitz D, 2010, CARDIOL REV, V18, P258, DOI 10.1097/CRD.0b013e3181ea0de0
   Wensaas AJ, 2009, DIABETES, V58, P527, DOI 10.2337/db08-1043
   Wolf M, 2002, J CLIN ENDOCR METAB, V87, P1563, DOI 10.1210/jc.87.4.1563
   Xie L, 2008, J NUTR, V138, P2222, DOI 10.3945/jn.108.096156
   Yamaguchi N, 2003, CHEMOSPHERE, V50, P265, DOI 10.1016/S0045-6535(02)00482-4
   Yamashita A, 2013, SCI REP-UK, V3, DOI 10.1038/srep03113
   Yashodhara BM, 2009, POSTGRAD MED J, V85, P84, DOI 10.1136/pgmj.2008.073338
   Yogev Y, 2009, OBSTET GYN CLIN N AM, V36, P285, DOI 10.1016/j.ogc.2009.03.003
   Zhou SJ, 2012, AM J CLIN NUTR, V95, P1378, DOI 10.3945/ajcn.111.033217
NR 195
TC 6
Z9 7
U1 0
U2 35
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-2010
EI 1873-4316
J9 CURR PHARM BIOTECHNO
JI Curr. Pharm. Biotechnol.
PY 2014
VL 15
IS 1
BP 84
EP 99
DI 10.2174/1389201015666140330195614
PG 16
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA AL1YD
UT WOS:000338921600010
PM 24720591
DA 2025-06-11
ER

PT J
AU Rider, P
   Voronov, E
   Dinarello, CA
   Apte, RN
   Cohen, I
AF Rider, Peleg
   Voronov, Elena
   Dinarello, Charles A.
   Apte, Ron N.
   Cohen, Idan
TI Alarmins: Feel the Stress
SO JOURNAL OF IMMUNOLOGY
LA English
DT Review
ID GROUP BOX 1; CHROMATIN PROTEIN HMGB1; N-TERMINAL PROPIECE; STERILE
   INFLAMMATION; POSTTRANSLATIONAL MODIFICATIONS; DNA-DAMAGE;
   SUBCELLULAR-LOCALIZATION; NUCLEAR TRANSLOCATION; METABOLIC SYNDROME;
   OXIDATIVE STRESS
AB Over the last decade, danger-associated molecular pattern molecules, or alarmins, have been recognized as signaling mediators of sterile inflammatory responses after trauma and injury. In contrast with the accepted passive release models suggested by the "danger hypothesis," it was recently shown that alarmins can also directly sense and report damage by signaling to the environment when released from live cells undergoing physiological stress, even without loss of subcellular compartmentalization. In this article, we review the involvement of alarmins such as IL-1 alpha, IL-33, IL-16, and high-mobility group box 1 in cellular and physiological stress, and suggest a novel activity of these molecules as central initiators of sterile inflammation in response to nonlethal stress, a function we denote "stressorins." We highlight the role of posttranslational modifications of stressorins as key regulators of their activity and propose that targeted inhibition of stressorins or their modifiers could serve as attractive new anti-inflammatory treatments for a broad range of diseases.
C1 [Rider, Peleg] Ben Gurion Univ Negev, Dept Clin Biochem & Pharmacol, IL-84105 Beer Sheva, Israel.
   [Voronov, Elena; Apte, Ron N.] Ben Gurion Univ Negev, Shraga Segal Dept Microbiol Immunol & Genet, IL-84105 Beer Sheva, Israel.
   [Dinarello, Charles A.] Univ Colorado Denver, Aurora, CO 80045 USA.
   [Cohen, Idan] Nahariya Hosp, Fac Med, Galilee Med Ctr, IL-22100 Nahariyya, Israel.
C3 Ben-Gurion University of the Negev; Ben-Gurion University of the Negev;
   Children's Hospital Colorado; University of Colorado System; University
   of Colorado Anschutz Medical Campus; Western Galilee Hospital
RP Cohen, I (corresponding author), Nahariya Hosp, Galilee Med Ctr, IL-22100 Nahariyya, Israel.
EM IdanC@gmc.gov.il
RI Dinarello, Charles/C-8524-2013; Cohen‬‏, ‪Idan/AAD-6997-2021
OI Cohen, Idan/0000-0001-6933-9385
FU Ministry of Aliya and Immigrant Asorption; Center for Absorption in
   Science, Israel; Israel Ministry of Science; Deutsches
   Krebsforschungscentrum, Heidelberg, Germany; Israel Science Foundation -
   Israel Academy of Sciences and Humanities; Israel Cancer Association;
   Israel Ministry of Health Chief Scientist's Office, 7th Framework
   Programme for Research and Technological Development: Cancer
   Inflammation (INFLA-CARE); Binational (Israel) Science Foundation;
   German-Israeli Foundation
FX This work was supported by the Ministry of Aliya and Immigrant Asorption
   (I.C.); the Center for Absorption in Science, Israel (I.C.); the Israel
   Ministry of Science jointly with the Deutsches Krebsforschungscentrum,
   Heidelberg, Germany (R.N.A. and E.V.); the Israel Science Foundation
   supported by the Israel Academy of Sciences and Humanities (R.N.A. and
   E.V.); the Israel Cancer Association and the Israel Ministry of Health
   Chief Scientist's Office, 7th Framework Programme for Research and
   Technological Development: Cancer Inflammation (INFLA-CARE) (R.N.A. and
   E.V.); the Binational (Israel) Science Foundation (R.N.A. and E.V.); and
   the German-Israeli Foundation (R.N.A. and E.V.).
CR Afonina IS, 2015, IMMUNITY, V42, P991, DOI 10.1016/j.immuni.2015.06.003
   [Anonymous], 2012, Comput Math Methods Med, DOI [DOI 10.1371/J0URNAL.P0NE.0035379, DOI 10.1155/2012/162892]
   [Anonymous], EVID BASED COMPLEMEN
   Appella E, 2001, EUR J BIOCHEM, V268, P2764, DOI 10.1046/j.1432-1327.2001.02225.x
   Arrigo T, 2013, EUR J ENDOCRINOL, V168, P631, DOI 10.1530/EJE-13-0037
   Bagaitkar J, 2015, BLOOD, V126, P2724, DOI 10.1182/blood-2015-05-644773
   Bald T, 2014, NATURE, V507, P109, DOI 10.1038/nature13111
   Bessa J, 2014, J AUTOIMMUN, V55, P33, DOI 10.1016/j.jaut.2014.02.012
   BEUSCHER HU, 1988, J BIOL CHEM, V263, P4023
   Bianchi ME, 2009, J LEUKOCYTE BIOL, V86, P573, DOI 10.1189/jlb.1008585
   Bianchi ME, 2005, CURR OPIN GENET DEV, V15, P496, DOI 10.1016/j.gde.2005.08.007
   Bonaldi T, 2003, EMBO J, V22, P5551, DOI 10.1093/emboj/cdg516
   Botelho FM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0028457
   Calogero S, 1999, NAT GENET, V22, P276, DOI 10.1038/10338
   Carriere V, 2007, P NATL ACAD SCI USA, V104, P282, DOI 10.1073/pnas.0606854104
   Carta S, 2013, FRONT IMMUNOL, V4, DOI 10.3389/fimmu.2013.00123
   Center DM, 2004, J IMMUNOL, V172, P1654, DOI 10.4049/jimmunol.172.3.1654
   Chandel NS, 2000, J BIOL CHEM, V275, P25130, DOI 10.1074/jbc.M001914200
   Chen GY, 2010, NAT REV IMMUNOL, V10, P826, DOI 10.1038/nri2873
   Cohen ES, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms9327
   Cohen I, 2016, SCI REP-UK, V6, DOI 10.1038/srep19100
   Cohen I, 2010, P NATL ACAD SCI USA, V107, P2574, DOI 10.1073/pnas.0915018107
   Cooke MS, 2003, FASEB J, V17, P1195, DOI 10.1096/fj.02-0752rev
   Cruikshank W, 2008, CRIT REV IMMUNOL, V28, P467
   Dinarello CA, 2014, LANCET ONCOL, V15, P552, DOI 10.1016/S1470-2045(14)70164-0
   Dudley Andrew C, 2004, Cell Commun Signal, V2, P8, DOI 10.1186/1478-811X-2-8
   Fabbro M, 2003, EXP CELL RES, V282, P59, DOI 10.1016/S0014-4827(02)00019-8
   Fang HL, 2014, CELL MOL IMMUNOL, V11, P150, DOI 10.1038/cmi.2013.59
   Federico A, 2007, INT J CANCER, V121, P2381, DOI 10.1002/ijc.23192
   FONG Y, 1989, AM J PHYSIOL, V256, pR659, DOI 10.1152/ajpregu.1989.256.3.R659
   Frank MG, 2015, BRAIN BEHAV IMMUN, V48, P1, DOI 10.1016/j.bbi.2015.03.010
   Freigang S, 2013, NAT IMMUNOL, V14, P1045, DOI 10.1038/ni.2704
   Fu AKY, 2016, P NATL ACAD SCI USA, V113, pE2705, DOI 10.1073/pnas.1604032113
   Gallucci S, 2001, CURR OPIN IMMUNOL, V13, P114, DOI 10.1016/S0952-7915(00)00191-6
   Gardella S, 2002, EMBO REP, V3, P995, DOI 10.1093/embo-reports/kvf198
   Grimaldi LME, 2000, ANN NEUROL, V47, P361, DOI 10.1002/1531-8249(200003)47:3<361::AID-ANA12>3.0.CO;2-N
   Gunasekaran MK, 2013, CYTOKINE, V64, P103, DOI 10.1016/j.cyto.2013.07.017
   Guzmán-Ruiz R, 2014, INT J OBESITY, V38, P1545, DOI 10.1038/ijo.2014.36
   Han SJ, 2015, CELL DEATH DIS, V6, DOI 10.1038/cddis.2015.199
   Hong DS, 2014, LANCET ONCOL, V15, P656, DOI 10.1016/S1470-2045(14)70155-X
   Hwang JS, 2015, SCI REP-UK, V5, DOI 10.1038/srep15971
   Ito I, 2007, J BIOL CHEM, V282, P16336, DOI 10.1074/jbc.M608467200
   Jabri B, 2015, NAT REV IMMUNOL, V15, P771, DOI 10.1038/nri3919
   Janik JE, 1997, J CLIN ENDOCR METAB, V82, P3084, DOI 10.1210/jc.82.9.3084
   Jiang H, 2013, NATURE, V496, P110, DOI 10.1038/nature12038
   Johnson KE, 2013, ARCH DERMATOL RES, V305, P805, DOI 10.1007/s00403-013-1401-2
   Karakasilioti I, 2013, CELL METAB, V18, P403, DOI 10.1016/j.cmet.2013.08.011
   Karatas H, 2013, SCIENCE, V339, P1092, DOI 10.1126/science.1231897
   Kazama H, 2008, IMMUNITY, V29, P21, DOI 10.1016/j.immuni.2008.05.013
   Kearley J, 2015, IMMUNITY, V42, P566, DOI 10.1016/j.immuni.2015.02.011
   Kim YH, 2016, J CELL SCI, V129, P29, DOI 10.1242/jcs.176412
   KOBAYASHI Y, 1988, J IMMUNOL, V140, P2279
   Kudinova AY, 2016, J ABNORM PSYCHOL, V125, P482, DOI 10.1037/abn0000158
   Kumar GK, 2008, RESP PHYSIOL NEUROBI, V164, P272, DOI 10.1016/j.resp.2008.05.017
   Kumar S, 2003, AM J PATHOL, V163, P2531, DOI 10.1016/S0002-9440(10)63608-5
   Kupper T S, 1988, Adv Dermatol, V3, P293
   Laurence A, 2004, EUR J IMMUNOL, V34, P587, DOI 10.1002/eji.200324598
   Lee PY, 2011, J IMMUNOL, V186, P1747, DOI 10.4049/jimmunol.1001328
   Lefrançais E, 2014, P NATL ACAD SCI USA, V111, P15502, DOI 10.1073/pnas.1410700111
   Lefrançais E, 2012, P NATL ACAD SCI USA, V109, P1673, DOI 10.1073/pnas.1115884109
   Lotze MT, 2005, NAT REV IMMUNOL, V5, P331, DOI 10.1038/nri1594
   Lu B, 2014, P NATL ACAD SCI USA, V111, P3068, DOI 10.1073/pnas.1316925111
   Luheshi NM, 2009, EUR J IMMUNOL, V39, P2973, DOI 10.1002/eji.200939712
   Maes M, 1997, CYTOKINE, V9, P853, DOI 10.1006/cyto.1997.0238
   Maes M, 2012, EXPERT OPIN THER TAR, V16, P1097, DOI 10.1517/14728222.2012.718331
   MAIER JAM, 1994, MOL CELL BIOL, V14, P1845, DOI 10.1128/MCB.14.3.1845
   Manzer R, 2008, AM J RESP CELL MOL, V38, P318, DOI 10.1165/rcmb.2007-0250OC
   MATZINGER P, 1994, ANNU REV IMMUNOL, V12, P991, DOI 10.1146/annurev.iy.12.040194.005015
   Matzinger P, 2002, SCIENCE, V296, P301, DOI 10.1126/science.1071059
   McCarthy DA, 2013, J BIOL CHEM, V288, P32149, DOI 10.1074/jbc.M113.493841
   McCarthy DA, 2013, REDOX BIOL, V1, P218, DOI 10.1016/j.redox.2013.03.001
   McMahon GA, 1997, J BIOL CHEM, V272, P28202, DOI 10.1074/jbc.272.45.28202
   Mirhafez SR, 2015, BRIT J NUTR, V113, P1911, DOI 10.1017/S0007114515001038
   Montes VN, 2015, NUTR DIABETES, V5, DOI 10.1038/nutd.2015.11
   Moussion C, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003331
   Müller S, 2004, J INTERN MED, V255, P332, DOI 10.1111/j.1365-2796.2003.01296.x
   Murota A, 2016, CYTOKINE, V78, P87, DOI 10.1016/j.cyto.2015.12.002
   Murray RZ, 2014, FRONT IMMUNOL, V5, DOI 10.3389/fimmu.2014.00538
   NOZAKI S, 1991, J INVEST DERMATOL, V97, P10, DOI 10.1111/1523-1747.ep12477727
   Oberle C, 2010, CURR GENOMICS, V11, P184, DOI 10.2174/138920210791110979
   Ohn T, 2010, WIRES RNA, V1, P486, DOI 10.1002/wrna.23
   Okin D, 2016, CELL, V165, P343, DOI 10.1016/j.cell.2016.02.023
   Pauwels NS, 2011, EUR RESPIR J, V38, P1019, DOI 10.1183/09031936.00158110
   Peter ME, 2008, IMMUNITY, V29, P1, DOI 10.1016/j.immuni.2008.06.006
   Piccinini AM, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/672395
   Pisetsky DS, 2008, ARTHRITIS RES THER, V10, DOI 10.1186/ar2440
   Pollock AS, 2003, FASEB J, V17, P203, DOI 10.1096/fj.02-0602com
   Richmond J, 2014, J CELL PHYSIOL, V229, P139, DOI 10.1002/jcp.24441
   Rider P, 2013, SEMIN IMMUNOL, V25, P430, DOI 10.1016/j.smim.2013.10.005
   Rider P, 2012, FRONT IMMUNOL, V3, DOI 10.3389/fimmu.2012.00290
   Rosa JS, 2008, PEDIATR DIABETES, V9, P9, DOI 10.1111/j.1399-5448.2007.00243.x
   Roussel L, 2008, EMBO REP, V9, P1006, DOI 10.1038/embor.2008.145
   Rubartelli A, 2013, FRONT IMMUNOL, V4, DOI 10.3389/fimmu.2013.00398
   Ryan BJ, 2014, REDOX BIOL, V2, P715, DOI 10.1016/j.redox.2014.05.004
   Scaffidi P, 2002, NATURE, V418, P191, DOI 10.1038/nature00858
   Stevenson FT, 1997, P NATL ACAD SCI USA, V94, P508, DOI 10.1073/pnas.94.2.508
   STEVENSON FT, 1993, P NATL ACAD SCI USA, V90, P7245, DOI 10.1073/pnas.90.15.7245
   Stone MJ, 2009, NEW BIOTECHNOL, V25, P299, DOI 10.1016/j.nbt.2009.03.011
   Tang DL, 2011, CELL METAB, V13, P701, DOI 10.1016/j.cmet.2011.04.008
   Um JY, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0029524
   Urbonaviciute V, 2009, AUTOIMMUNITY, V42, P305, DOI 10.1080/08916930902831803
   Vucic D, 2011, NAT REV MOL CELL BIO, V12, P439, DOI 10.1038/nrm3143
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Wilson KC, 2002, BIOCHEMISTRY-US, V41, P14306, DOI 10.1021/bi020163v
   Wiseman H, 1996, BIOCHEM J, V313, P17, DOI 10.1042/bj3130017
   Wu F, 2013, ASIAN PAC J CANCER P, V14, P5789, DOI 10.7314/APJCP.2013.14.10.5789
   Wu MK, 2015, NEUROPSYCH DIS TREAT, V11, P1853, DOI 10.2147/NDT.S88430
   Xu YM, 2012, J PROTEOME RES, V11, P2625, DOI 10.1021/pr201151a
   Yang ZY, 2014, J IMMUNOL, V193, P6114, DOI 10.4049/jimmunol.1400359
   Yellapa A, 2014, AM J OBSTET GYNECOL, V210, DOI 10.1016/j.ajog.2013.12.041
   Youn JH, 2006, J IMMUNOL, V177, P7889, DOI 10.4049/jimmunol.177.11.7889
   Yu Y, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00093
   Zhang YJ, 2001, J BIOL CHEM, V276, P1299, DOI 10.1074/jbc.M008513200
   Zheng Y, 2013, IMMUNITY, V38, P285, DOI 10.1016/j.immuni.2013.01.008
NR 114
TC 143
Z9 158
U1 0
U2 18
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD FEB 15
PY 2017
VL 198
IS 4
BP 1395
EP 1402
DI 10.4049/jimmunol.1601342
PG 8
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA EN3HC
UT WOS:000395898600003
PM 28167650
DA 2025-06-11
ER

PT J
AU Nina, N
   Theoduloz, C
   Tapia, G
   Jimenéz-Aspee, F
   Márquez, K
   Schmeda-Hirschmann, G
AF Nina, Nelida
   Theoduloz, Cristina
   Tapia, Gerardo
   Jimenez-Aspee, Felipe
   Marquez, Katherine
   Schmeda-Hirschmann, Guillermo
TI Changes in polyphenol composition, antioxidant capacity and enzyme
   inhibition in Phaseolus vulgaris L. submitted to hydric stress
SO SCIENTIA HORTICULTURAE
LA English
DT Article
DE Water stress; Latin American beans; Phenolics; Enzyme inhibition;
   alpha-glucosidase; alpha-amylase; Phaseolus vulgaris
ID CURRANTS RIBES SPP.; DROUGHT STRESS; COMMON; BEANS; PHENOLICS; ASSAY
AB The beans (Phaseolus vulgaris L.) are native American legumes with high nutritional value and health benefits. The aim of this study was to assess the impact of hydric stress on the phenolic composition, antioxidant capacity, and inhibition of enzymes associated with metabolic syndrome, in nine bean landraces cultivated in the Mediterranean zone of Chile. The polyphenolic enriched extract (PEE) from the seeds were analyzed for total phenolic, flavonoid, proanthocyanidin content, and antioxidant capacity. The main compounds were quantified by HPLC. The activity of the extracts on the enzymes alpha-glucosidase, alpha-amylase, and pancreatic lipase was assessed. Under restricted watering, all phenolic compounds increased in Pinto beans and decreased in other accessions. Best effect towards alpha-glucosidase was observed for Negro Argel, Bayote, and Enriqueta with IC50 between 0.006 mu g/mL and 0.820 mu g/mL. Water stress has a significant effect on polyphenols composition and consequently on the antioxidant activity and inhibition of enzymes.
C1 [Nina, Nelida; Schmeda-Hirschmann, Guillermo] Univ Talca, Lab Quim Prod Nat, Inst Quim Recursos Nat, Campus Lircay, Talca 3480094, Chile.
   [Theoduloz, Cristina] Univ Talca, Fac Ciencias Salud, Lab Cult Celular, Campus Lircay, Talca 3480094, Chile.
   [Tapia, Gerardo] Inst Invest Agr, INIA Quilamapu, Unidad Recursos Genet Vegetales, Chillan 3800062, Chile.
   [Jimenez-Aspee, Felipe] Univ Hohenheim, Inst Nutr Sci, Dept Food Biofunct 140b, D-70599 Stuttgart, Germany.
   [Theoduloz, Cristina; Tapia, Gerardo; Marquez, Katherine; Schmeda-Hirschmann, Guillermo] Ctr Estudios Alimentos Proc CEAP, Campus Lircay, Talca 3480094, Chile.
   [Schmeda-Hirschmann, Guillermo] Univ Talca, Inst Quim Recursos Nat, Lab Quim Prod Nat, Talca 3480094, Chile.
C3 Universidad de Talca; Universidad de Talca; University Hohenheim;
   Universidad de Talca
RP Schmeda-Hirschmann, G (corresponding author), Univ Talca, Inst Quim Recursos Nat, Lab Quim Prod Nat, Talca 3480094, Chile.
EM schmeda@utalca.cl
RI Márquez, Katherine/JDM-7512-2023; Aspee, Felipe/ABA-2948-2020; Jimenez
   Aspee, Felipe/G-6955-2017; Schmeda Hirschmann, Guillermo/G-1046-2010
OI Jimenez Aspee, Felipe/0000-0002-7285-7033; Marquez,
   Katherine/0000-0001-6298-2597; Schmeda Hirschmann,
   Guillermo/0000-0002-9228-5378
FU FONDECYT [1210076]; Proyecto Fortalecimiento al Desarrollo Cientifico de
   Centros Regionales-ANID; ANID;  [R20F0001CEAP];  [21192237]
FX This research received funding from FONDECYT 1210076 and Proyecto
   Fortalecimiento al Desarrollo Cientifico de Centros Regionales-ANID
   R20F0001CEAP. N.N. thanks ANID for a doctoral grant Folio 21192237. We
   are grateful to Dr. J. Alarc'on-Esp'osito for her technical help.
CR Ahmadi SM, 2020, J FOOD SCI, V85, P298, DOI 10.1111/1750-3841.14994
   Alarcón-Espósito J, 2022, PLANT FOOD HUM NUTR, V77, P135, DOI 10.1007/s11130-022-00955-6
   Antolin LAS, 2021, AGR SYST, V191, DOI 10.1016/j.agsy.2021.103174
   Aparicio-Fernández X, 2006, J AGR FOOD CHEM, V54, P2116, DOI 10.1021/jf052974m
   Asfaw A, 2017, FRONT PLANT SCI, V8, DOI 10.3389/fpls.2017.00733
   Avila F, 2022, J FUNCT FOODS, V98, DOI 10.1016/j.jff.2022.105270
   Bai Y, 2017, J FUNCT FOODS, V35, P694, DOI 10.1016/j.jff.2017.06.036
   Becerra-Tomás N, 2019, ADV NUTR, V10, pS437, DOI 10.1093/advances/nmz003
   Sánchez-Rangel JC, 2013, ANAL METHODS-UK, V5, P5990, DOI 10.1039/c3ay41125g
   Chen PX, 2015, FOOD CHEM, V185, P298, DOI 10.1016/j.foodchem.2015.03.100
   Coelho SRM, 2020, LWT-FOOD SCI TECHNOL, V117, DOI 10.1016/j.lwt.2019.108673
   De Ron AM., 2015, Grain Legumes, P1, DOI [10.1007/978-1-4939-2797-5_1, DOI 10.1007/978-1-4939-2797-5_1]
   Herrera MD, 2021, J FOOD COMPOS ANAL, V99, DOI 10.1016/j.jfca.2021.103883
   Herrera MD, 2019, FOOD CHEM, V294, P368, DOI 10.1016/j.foodchem.2019.05.076
   Dirir AM, 2022, PHYTOCHEM REV, V21, P1049, DOI 10.1007/s11101-021-09773-1
   García-Lafuente A, 2014, FOOD CHEM, V161, P216, DOI 10.1016/j.foodchem.2014.04.004
   Guajardo-Flores D, 2013, FOOD CHEM, V141, P1497, DOI 10.1016/j.foodchem.2013.04.010
   Hummel M, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-33952-4
   INIA, 2020, PROD NAC LEG CUENT C
   Jha UC, 2020, PLANT BREEDING, V139, P1, DOI 10.1111/pbr.12761
   Jiménez-Aspee F, 2016, J FUNCT FOODS, V26, P11, DOI 10.1016/j.jff.2016.06.036
   Khatun M, 2021, AGRONOMY-BASEL, V11, DOI 10.3390/agronomy11122374
   Kusvuran S, 2017, LEGUME RES, V40, P55, DOI 10.18805/lr.v0i0.7025
   Lee J, 2005, J AOAC INT, V88, P1269
   Li SD, 2021, ATMOSPHERE-BASEL, V12, DOI 10.3390/atmos12121591
   Mojica L, 2015, FOOD RES INT, V69, P38, DOI 10.1016/j.foodres.2014.12.007
   Moreno-Valdespino CA, 2020, FOOD RES INT, V130, DOI 10.1016/j.foodres.2019.108905
   Nina N, 2020, FOOD RES INT, V137, DOI 10.1016/j.foodres.2020.109382
   Nolan Paul B, 2017, Prev Med Rep, V7, P211, DOI 10.1016/j.pmedr.2017.07.004
   Paredes M, 2010, CHIL J AGR RES, V70, P3
   Peiretti PG, 2019, AGRONOMY-BASEL, V9, DOI 10.3390/agronomy9030153
   Petropoulos SA, 2019, J SCI FOOD AGR, V99, P6049, DOI 10.1002/jsfa.9881
   Pitura K, 2019, FOOD CHEM, V272, P26, DOI 10.1016/j.foodchem.2018.07.220
   Rosales MA, 2012, PLANT PHYSIOL BIOCH, V56, P24, DOI 10.1016/j.plaphy.2012.04.007
   Salas M.P.A.F., 2018, SERIE ESTUDIOS INNOV
   Samec D, 2021, PLANTS-BASEL, V10, DOI 10.3390/plants10010118
   Schmeda-Hirschmann G, 2021, FOOD CHEM, V350, DOI 10.1016/j.foodchem.2021.129241
   Tapia G, 2022, PLANTS-BASEL, V11, DOI 10.3390/plants11060749
   Theoduloz C, 2018, FOOD BIOSCI, V24, P80, DOI 10.1016/j.fbio.2018.06.003
   Thompson HJ, 2019, NUTRIENTS, V11, DOI 10.3390/nu11123074
   Traub J, 2017, CROP SCI, V57, P1670, DOI 10.2135/cropsci2016.09.0746
   Trucchi E, 2021, NAT PLANTS, V7, DOI 10.1038/s41477-021-00848-7
   Wallace TC, 2010, J FOOD SCI, V75, pC619, DOI 10.1111/j.1750-3841.2010.01734.x
   Willemse CM, 2013, J CHROMATOGR A, V1319, P127, DOI 10.1016/j.chroma.2013.10.045
   Yadav B, 2021, GENE REP, V23, DOI 10.1016/j.genrep.2021.101040
   Yang QQ, 2018, COMPR REV FOOD SCI F, V17, P1518, DOI 10.1111/1541-4337.12391
   Zou JN, 2021, IND CROP PROD, V163, DOI 10.1016/j.indcrop.2021.113323
NR 47
TC 11
Z9 11
U1 4
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0304-4238
EI 1879-1018
J9 SCI HORTIC-AMSTERDAM
JI Sci. Hortic.
PD JUL 1
PY 2023
VL 317
AR 112070
DI 10.1016/j.scienta.2023.112070
EA APR 2023
PG 10
WC Horticulture
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA G0YH0
UT WOS:000986510400001
DA 2025-06-11
ER

PT S
AU Vrekoussis, T
   Kalantaridou, SN
   Mastorakos, G
   Zoumakis, E
   Makrigiannakis, A
   Syrrou, M
   Lavasidis, LG
   Relakis, K
   Chrousos, GP
AF Vrekoussis, Thomas
   Kalantaridou, Sophia N.
   Mastorakos, George
   Zoumakis, Emmanuel
   Makrigiannakis, Antonis
   Syrrou, Marika
   Lavasidis, Lazaros G.
   Relakis, Kostas
   Chrousos, George P.
BE Creatsas, G
   Mastorakos, G
TI The role of stress in female reproduction and pregnancy: an update
SO WOMEN'S HEALTH AND DISEASE
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 7th Athens Conference on Women's Health and Disease: Gynecologic,
   Endocrine, and Reproductive Issues
CY SEP 11-13, 2008
CL Athens, GREECE
DE fetal programming; female reproduction; parturition; pregnancy; stress
ID CORTICOTROPIN-RELEASING HORMONE; FETAL-GROWTH RESTRICTION;
   HUMAN-PLACENTA; PRETERM BIRTH; BINDING PROTEIN; PRENATAL STRESS;
   PREECLAMPSIA; PLASMA; AXIS; CRH
AB Life exists by establishing a balanced equilibrium, called homeostasis, constantly challenged by adverse stimuli, called stressors. In response to these stimuli, a complex neurohormonal reaction exerted by the activation of the so-called stress system is initiated. The latter is activated in a coordinated fashion, leading to behavioral and peripheral changes that improve the ability of the organism to adjust homeostasis and increase its chance for survival. The stress system suppressive effects on female reproduction involve suppression of the hypothalamic pituitary ovarian axis at the hypothalamic, pituitary, ovarian, and uterine levels. Experimental and human data suggest that adverse prenatal stimuli, of either maternal or fetal origin, acting in the developing embryo in utero, can lead to the development of short-and long-term health disorders. These include preterm birth of the offspring, low birth weight, and the development of adult diseases ranging from the metabolic syndrome to several neurodevelopmental disorders.
C1 [Vrekoussis, Thomas; Kalantaridou, Sophia N.; Lavasidis, Lazaros G.] Univ Ioannina, Sch Med, Dept Obstet & Gynecol, GR-45110 Ioannina, Greece.
   [Mastorakos, George] Univ Athens, Sch Med, Aretaie Hosp, Dept Obstet & Gynecol 2, GR-11527 Athens, Greece.
   [Zoumakis, Emmanuel; Chrousos, George P.] Univ Athens, Dept Pediat 1, Choreme Res Lab, Athens, Greece.
   [Makrigiannakis, Antonis; Relakis, Kostas] Univ Crete, Sch Med, Dept Obstet & Gynecol, Iraklion, Greece.
   [Syrrou, Marika] Univ Ioannina, Sch Med, Dept Gen Biol, Genet Unit, GR-45110 Ioannina, Greece.
C3 University of Ioannina; National & Kapodistrian University of Athens;
   Athens Medical School; National & Kapodistrian University of Athens;
   University of Crete; University of Ioannina
RP Vrekoussis, T (corresponding author), Univ Ioannina, Sch Med, Dept Obstet & Gynecol, GR-45110 Ioannina, Greece.
EM tvrek@med.uoc.gr
RI Chrousos, George/G-8702-2011
OI Makrigiannakis, Antonis/0000-0002-8475-1500; Kalantaridou,
   Sophia/0000-0002-0590-1575; SYRROU, MARIA/0000-0002-5748-5008
CR Bamberger AM, 2006, AM J PATHOL, V168, P141, DOI 10.2353/ajpath.2006.050167
   Bateson P, 2004, NATURE, V430, P419, DOI 10.1038/nature02725
   Benediktsson R, 1997, CLIN ENDOCRINOL, V46, P161, DOI 10.1046/j.1365-2265.1997.1230939.x
   Challis JRG, 2000, ENDOCR REV, V21, P514, DOI 10.1210/er.21.5.514
   CHALLIS JRG, 1995, PLACENTA, V16, P481, DOI 10.1016/S0143-4004(05)80001-3
   Chrousos George P., 1998, Annals of Internal Medicine, V129, P229
   CHROUSOS GP, 1992, JAMA-J AM MED ASSOC, V267, P1244, DOI 10.1001/jama.267.9.1244
   CLIFTON VL, 1995, J CLIN ENDOCR METAB, V80, P2888, DOI 10.1210/jc.80.10.2888
   Clifton VL, 1998, J CLIN ENDOCR METAB, V83, P3716, DOI 10.1210/jc.83.10.3716
   Fowden AL, 2006, PHYSIOLOGY, V21, P29, DOI 10.1152/physiol.00050.2005
   FRIM DM, 1988, J CLIN INVEST, V82, P287, DOI 10.1172/JCI113585
   GOLAND RS, 1993, J CLIN ENDOCR METAB, V77, P1174, DOI 10.1210/jc.77.5.1174
   GOLAND RS, 1986, J CLIN ENDOCR METAB, V63, P1199, DOI 10.1210/jcem-63-5-1199
   Grammatopoulos DK, 1999, LANCET, V354, P1546, DOI 10.1016/S0140-6736(99)03418-2
   Jones A, 2006, J CLIN ENDOCR METAB, V91, P1868, DOI 10.1210/jc.2005-2077
   Kalantaridou SN, 2010, J REPROD IMMUNOL, V85, P33, DOI 10.1016/j.jri.2010.02.005
   Karteris E, 2005, J CLIN ENDOCR METAB, V90, P3680, DOI 10.1210/jc.2004-2210
   Karteris E, 2003, J CLIN ENDOCR METAB, V88, P363, DOI 10.1210/jc.2002-020375
   Kinzler WL, 2007, SEMIN PERINATOL, V31, P126, DOI 10.1053/j.semperi.2007.03.004
   Li W, 2005, J CLIN ENDOCR METAB, V90, P6569, DOI 10.1210/jc.2005-1445
   LINTON EA, 1993, J CLIN ENDOCR METAB, V76, P260, DOI 10.1210/jc.76.1.260
   Makrigiannakis A, 2001, NAT IMMUNOL, V2, P1018, DOI 10.1038/ni719
   Makrigiannakis A, 2003, BIOCHEM PHARMACOL, V65, P917, DOI 10.1016/S0006-2952(02)01547-2
   Matthews SG, 2002, TRENDS ENDOCRIN MET, V13, P373, DOI 10.1016/S1043-2760(02)00690-2
   MCLEAN M, 1995, NAT MED, V1, P460, DOI 10.1038/nm0595-460
   Merlot E, 2008, BRAIN BEHAV IMMUN, V22, P42, DOI 10.1016/j.bbi.2007.05.007
   MURGATROYD C, 2010, EPIGENETICS, V59, P194
   Norwitz ER, 2009, J CLIN ENDOCR METAB, V94, P1886, DOI 10.1210/jc.2009-0706
   O'Donnell K, 2009, DEV NEUROSCI-BASEL, V31, P285, DOI 10.1159/000216539
   PERKINS AV, 1995, BRIT J OBSTET GYNAEC, V102, P118, DOI 10.1111/j.1471-0528.1995.tb09063.x
   Phillips DIW, 1998, J CLIN ENDOCR METAB, V83, P757, DOI 10.1210/jc.83.3.757
   REUL JMHM, 1994, J CLIN INVEST, V93, P2600, DOI 10.1172/JCI117272
   RILEY SC, 1991, J CLIN ENDOCR METAB, V72, P1001, DOI 10.1210/jcem-72-5-1001
   Rusterholz C, 2007, SEMIN IMMUNOPATHOL, V29, P151, DOI 10.1007/s00281-007-0071-6
   Schiessl B, 2007, MOL ASPECTS MED, V28, P210, DOI 10.1016/j.mam.2007.04.004
   Sibai BM, 2006, SEMIN PERINATOL, V30, P16, DOI 10.1053/j.semperi.2006.01.008
   Smith R, 2007, NEW ENGL J MED, V356, P271, DOI 10.1056/NEJMra061360
   Swamy GK, 2008, JAMA-J AM MED ASSOC, V299, P1429, DOI 10.1001/jama.299.12.1429
   Wadhwa PD, 2005, PSYCHONEUROENDOCRINO, V30, P724, DOI 10.1016/j.psyneuen.2005.02.004
   Wadhwa PD, 2004, AM J OBSTET GYNECOL, V191, P1063, DOI 10.1016/j.ajog.2004.06.070
NR 40
TC 45
Z9 52
U1 2
U2 19
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA
SN 0077-8923
BN 978-1-57331-768-9
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2010
VL 1205
BP 69
EP 75
DI 10.1111/j.1749-6632.2010.05686.x
PG 7
WC Endocrinology & Metabolism; Multidisciplinary Sciences; Obstetrics &
   Gynecology; Reproductive Biology
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Science & Technology - Other Topics;
   Obstetrics & Gynecology; Reproductive Biology
GA BRM37
UT WOS:000283095800011
PM 20840255
DA 2025-06-11
ER

PT J
AU Almenara, CCP
   Mill, JG
   Vassallo, DV
   Bald, MP
   Padilha, AS
AF Almenara, Camila C. P.
   Mill, Jose G.
   Vassallo, Dalton V.
   Bald, Marcelo P.
   Padilha, Alessandra S.
TI In vitro fructose exposure overactivates NADPH oxidase and causes
   oxidative stress in the isolated rat aorta
SO TOXICOLOGY IN VITRO
LA English
DT Article
DE Fructose; Oxidative stress; NADPH oxidase; Endothelial dysfunction
ID INDUCED METABOLIC SYNDROME; INSULIN-RESISTANCE; NITRIC-OXIDE; VASCULAR
   DYSFUNCTION; EXPERIMENTAL-MODEL; CORN SYRUP; HYPERTENSION; SUCROSE;
   ATORVASTATIN; RELAXATION
AB Fructose acutely interferes with cardiovascular function in humans and in animals, but the mechanisms remain unclear. Thus, we tested whether fructose can affect endothelial function without the interference of its metabolic effect by exposing the rat aorta to a high fructose concentration and then evaluate the vascular responses to vasoactive agents. We observed that fructose exposure causes overactivation of NADPH oxidase, which enhances superoxide anion production and increases NO degradation. Additionally, the enhanced vasoconstrictor action of hydrogen peroxide might exacerbate contractile responses. This vasoactive imbalance might be the key role by which fructose induces vascular dysfunction. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Almenara, Camila C. P.; Mill, Jose G.; Vassallo, Dalton V.; Bald, Marcelo P.; Padilha, Alessandra S.] Univ Fed Espirito Santo, Dept Physiol Sci, Vitoria, ES, Brazil.
   [Mill, Jose G.] Univ Fed Espirito Santo, Post Grad Program Collect Hlth, BR-29042755 Vitoria, ES, Brazil.
C3 Universidade Federal do Espirito Santo; Universidade Federal do Espirito
   Santo
RP Padilha, AS (corresponding author), Univ Fed Espirito Santo, Ctr Ciencias Saude, Dept Ciencias Fisiol, Ave Marechal Campos 1468, BR-29040091 Vitoria, ES, Brazil.
EM ale_padilha@hotmail.com
RI Baldo, Marcelo/G-6994-2012; Vassallo, Dalton/K-8289-2016
OI Vassallo, Dalton/0000-0002-4463-4174; Baldo, Marcelo/0000-0002-7673-3580
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq
   [470748/2013-3, 400484/2013-7]; CAPES (Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior)
FX This work was supported by grants from the Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico - CNPq [470748/2013-3;
   400484/2013-7] and CAPES (Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior). The funders had no role in the study design, data
   collection and analysis, decision to publish or preparation of the
   manuscript. The authors declare that they have no conflicts of interest.
CR Alvarez Y, 2007, J PHARMACOL EXP THER, V321, P381, DOI 10.1124/jpet.106.115287
   Babacanoglu C, 2013, FOOD CHEM TOXICOL, V60, P160, DOI 10.1016/j.fct.2013.07.026
   Bray GA, 2013, PEDIATR OBES, V8, P242, DOI 10.1111/j.2047-6310.2013.00171.x
   Bray GA, 2004, AM J CLIN NUTR, V79, P537
   Cai H, 2003, MOL PHARMACOL, V63, P325, DOI 10.1124/mol.63.2.325
   CHICCO A, 1994, HORM METAB RES, V26, P397, DOI 10.1055/s-2007-1001717
   COHEN RA, 2006, TRENDS CARDIOVAS MED
   Davel AP, 2012, J VASC RES, V49, P342, DOI 10.1159/000337486
   El-Bassossy HM, 2015, TRANSL RES, V165, P621, DOI 10.1016/j.trsl.2014.11.008
   El-Bassossy HM, 2014, TOXICOL MECH METHOD, V24, P536, DOI 10.3109/15376516.2014.945109
   Endo MY, 2014, J PHYSIOL ANTHROPOL, V33, DOI 10.1186/1880-6805-33-11
   Feinman RD, 2013, NUTR METAB, V10, DOI 10.1186/1743-7075-10-45
   Gaby AR, 2005, ALTERN MED REV, V10, P294
   Hanover LM., 1993, Am J Clin Nutr, V58, p724S732S
   HWANG IS, 1987, HYPERTENSION, V10, P512, DOI 10.1161/01.HYP.10.5.512
   Ishimoto T, 2012, P NATL ACAD SCI USA, V109, P4320, DOI 10.1073/pnas.1119908109
   Jalal DI, 2010, J AM SOC NEPHROL, V21, P1543, DOI 10.1681/ASN.2009111111
   Johnson RK, 2009, CIRCULATION, V120, P1011, DOI 10.1161/CIRCULATIONAHA.109.192627
   KAWASAKI T, 2002, DIABETES CARE
   Klein AV, 2015, J HYPERTENS, V33, P912, DOI 10.1097/HJH.0000000000000551
   Koborova Ivana, 2015, Vnitr Lek, V61, P42
   MACDONALD I, 1978, AM J CLIN NUTR, V31, P1305, DOI 10.1093/ajcn/31.8.1305
   Madero M, 2011, CURR HYPERTENS REP, V13, P29, DOI 10.1007/s11906-010-0163-x
   Mahmoud MF, 2012, ARCH PHARM RES, V35, P155, DOI 10.1007/s12272-012-0117-8
   Miatello R, 2002, AM J HYPERTENS, V15, P872, DOI 10.1016/S0895-7061(02)02983-7
   Moncada S, 2006, BRIT J PHARMACOL, V147, pS193, DOI 10.1038/sj.bjp.0706458
   Montezano AC, 2012, BASIC CLIN PHARMACOL, V110, P87, DOI 10.1111/j.1742-7843.2011.00785.x
   MORENO JA, 2012, NUTR METAB CARDIOVAS
   NORTON CE, 2012, ANTIOXID REDOX SIGN
   Novak A, 2015, NUTRITION, V31, P871, DOI 10.1016/j.nut.2015.01.003
   Nyby MD, 2007, HYPERTENS RES, V30, P451, DOI 10.1291/hypres.30.451
   Okamura T, 2014, J PHARMACOL SCI, V124, P76, DOI 10.1254/jphs.13178FP
   PALANISAMY N, 2012, BR J NUTR
   Paravicini TM, 2008, DIABETES CARE, V31, pS170, DOI 10.2337/dc08-s247
   Peredo H. A., 2006, Autonomic & Autacoid Pharmacology, V26, P15, DOI 10.1111/j.1474-8673.2005.00354.x
   PREUSS HG, 1992, AM J HYPERTENS, V5, P244, DOI 10.1093/ajh/5.4.244
   RICHEY JM, 1998, LIFE SCI, V62, pL55
   RODRIGUEZ L, 2015, EUR J NUTR
   Satoh K, 2014, J MOL CELL CARDIOL, V73, P50, DOI 10.1016/j.yjmcc.2013.12.022
   Slyper AH, 2013, J PEDIATR ENDOCR MET, V26, P617, DOI 10.1515/jpem-2012-0419
   SUN SZ, 2012, NUTR METAB
   Takagawa Y, 2001, AM J HYPERTENS, V14, P811, DOI 10.1016/S0895-7061(01)01298-5
   Touyz RM, 2005, ARTERIOSCL THROM VAS, V25, P512, DOI 10.1161/01.ATV.0000154141.66879.98
   Verma S, 1996, AM J HYPERTENS, V9, P370, DOI 10.1016/0895-7061(95)00392-4
   Yanai H, 2008, NUTR J, V7, DOI 10.1186/1475-2891-7-10
NR 45
TC 12
Z9 12
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0887-2333
EI 1879-3177
J9 TOXICOL IN VITRO
JI Toxicol. Vitro
PD DEC
PY 2015
VL 29
IS 8
BP 2030
EP 2037
DI 10.1016/j.tiv.2015.08.013
PG 8
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA CW3KU
UT WOS:000364892000009
PM 26320835
DA 2025-06-11
ER

PT J
AU Petrova, J
   Cherneva, R
   Georgiev, O
   Petrova, D
   Valev, D
AF Petrova, Julia
   Cherneva, Radostina
   Georgiev, Ognian
   Petrova, Daniela
   Valev, Dinko
TI THE ROLE OF OXIDATIVE STRESS IN ENDOTHELIAL DYSFUNCTION IN OSA PATIENTS
SO COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES
LA English
DT Article
DE endothelial dysfunction; flow mediated brachial artery dilation (FMD);
   oxidative stress; OSA
ID OBSTRUCTIVE SLEEP-APNEA; LIPID-PEROXIDATION; NITRIC-OXIDE; FLOW;
   VASODILATION; MARKERS
AB Endothelial dysfunction is highly prevalent among OSA patients. However, its pathogenetic mechanisms are not thoroughly studied. The aim of our study was to evaluate the role of oxidative stress in the pathogenesis of endothelial dysfunction among OSA patients and to compare it to healthy control subjects. We studied 98 consecutive patients, who were referred to the clinic for probable OSA. Patients underwent standard polysomnography. To assess oxidative stress, we measured urinary 8-iso-PGF2 alpha. Flow mediated brachial artery dilation (FMD) was determined to assess endothelial function. Patients with moderate-severe OSAS had higher urinary 8-iso-PGF2 alpha (0.021 pg/mu mo1/1 cre), compared to healthy subjects (0.017 pg/mu mo1/1 cre, p = 0.037). In contrast to metabolic syndrome urinary 8-isoprostanes were the only independent predictors of FMD (beta = -0.21, p < 0.048). In conclusion, the results of our study indicate that patients with OSAS have an increased oxidative stress, that is implicated in the pathogenesis of arterial dysfunction.
C1 [Petrova, Julia; Cherneva, Radostina] Med Univ Sofia, Dept Neurol, Sofia, Bulgaria.
   [Georgiev, Ognian; Petrova, Daniela; Valev, Dinko] Med Univ Sofia, Div Pulm Med, Sofia 1431, Bulgaria.
C3 Medical University Sofia; Medical University Sofia
RP Petrova, J (corresponding author), Med Univ Sofia, Dept Neurol, Sofia, Bulgaria.
EM cherneva_radost@yahoo.com
RI Petrova, Daniela/GXA-2866-2022; Valev, Dimitar/E-6179-2011
CR Barceló A, 2000, EUR RESPIR J, V16, P644, DOI 10.1034/j.1399-3003.2000.16d13.x
   Büchner NJ, 2011, RESPIRATION, V82, P409, DOI 10.1159/000323266
   Carpagnano GE, 2003, CHEST, V124, P1386, DOI 10.1378/chest.124.4.1386
   Cherneva RV, 2013, RES REP CLIN CARDIOL, V4, P67, DOI 10.2147/RRCC.S43193
   Chung S, 2007, SLEEP, V30, P997, DOI 10.1093/sleep/30.8.997
   Cooke JP, 2003, P NATL ACAD SCI USA, V100, P768, DOI 10.1073/pnas.0430082100
   Corretti MC, 2002, J AM COLL CARDIOL, V39, P257, DOI 10.1016/S0735-1097(01)01746-6
   Dyugovskaya L, 2002, AM J RESP CRIT CARE, V165, P934, DOI 10.1164/ajrccm.165.7.2104126
   Grebe M, 2006, AM J RESP CRIT CARE, V173, P897, DOI 10.1164/rccm.200508-1223OC
   Ip MSM, 2004, AM J RESP CRIT CARE, V169, P348, DOI 10.1164/rccm.200306-767OC
   Ip MSM, 2000, AM J RESP CRIT CARE, V162, P2166, DOI 10.1164/ajrccm.162.6.2002126
   JOANNIDES R, 1995, CIRCULATION, V91, P1314, DOI 10.1161/01.CIR.91.5.1314
   Kato M, 2000, CIRCULATION, V102, P2607
   Katsoulis K, 2011, SLEEP BREATH, V15, P861, DOI 10.1007/s11325-010-0456-y
   Lavie L, 2004, SLEEP, V27, P123
   Lee SD, 2012, SLEEP BREATH, V16, P511, DOI 10.1007/s11325-011-0536-7
   Nieto FJ, 2004, AM J RESP CRIT CARE, V169, P354, DOI 10.1164/rccm.200306-756OC
   Oflaz H, 2006, RESPIRATION, V73, P751, DOI 10.1159/000094183
   Qaseem A, 2013, ANN INTERN MED, V159, P471, DOI 10.7326/00030003-4819-159-7-201310010-00704
   Svatikova A, 2005, EUR HEART J, V26, P2435, DOI 10.1093/eurheartj/ehi440
NR 20
TC 0
Z9 0
U1 1
U2 3
PU PUBL HOUSE BULGARIAN ACAD SCI
PI SOFIA
PA ACADEMICIAN G BONCEV ST, 1113 SOFIA, BULGARIA
SN 1310-1331
J9 CR ACAD BULG SCI
JI C. R. Acad. Bulg. Sci.
PY 2015
VL 68
IS 11
BP 1457
EP 1462
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DA2OB
UT WOS:000367634600016
DA 2025-06-11
ER

PT J
AU Charradi, K
   Elkahoui, S
   Karkouch, I
   Limam, F
   Hamdaoui, G
   Ben Hassine, F
   El May, MV
   El May, A
   Aouani, E
AF Charradi, Kamel
   Elkahoui, Salem
   Karkouch, Ines
   Limam, Ferid
   Hamdaoui, Ghaith
   Ben Hassine, Fethy
   El May, Michele Veronique
   El May, Ahmed
   Aouani, Ezzedine
TI Grape seed and skin extract alleviates high-fat diet-induced renal
   lipotoxicity and prevents copper depletion in rat
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE copper; grape polyphenols; kidney; obesity; oxidative stress
ID CHRONIC KIDNEY-DISEASE; METABOLIC SYNDROME; OXIDATIVE STRESS; OBESITY;
   BIOAVAILABILITY; APOPTOSIS; SERUM; ACID; ZINC
AB Obesity is a public health problem that contributes to morbidity and mortality from diabetes, heart disease, stroke, and cancers. The purpose of this investigation was to analyse the link between obesity-induced oxidative stress, renal steatosis, and kidney dysfunction, as well as the protective effect of grape seed and skin extract. Rats were fed a standard diet or a high-fat diet for 6 weeks and were either treated or not treated with grape seed and skin extract. Fat-induced oxidative stress was evaluated in the kidney with a special emphasis on transition metals. High-fat diet induced triglyceride deposition and disturbances in kidney function parameters, which are linked to an oxidative stress status and depletion of copper from the kidney. Grape seed and skin extract abrogated almost all fat-induced kidney disturbances. Grape seed and skin extract exerted potential protection against fat-induced kidney lipotoxicity and should find potential application in other kidney-related diseases.
C1 [Charradi, Kamel; Elkahoui, Salem; Karkouch, Ines; Limam, Ferid; Hamdaoui, Ghaith; Aouani, Ezzedine] Ctr Biotechnol Borj Cedria, Lab Subst Bioact LSBA, Hammam Lif 2050, Tunisia.
   [Charradi, Kamel; Aouani, Ezzedine] Univ Carthage, Fac Sci Bizerte, Jarzouna 7021, Tunisia.
   [Ben Hassine, Fethy] CNSS El Khadra, Polyclin, Biochim Lab, Cite El Khadra Tunis 1003, Tunisia.
   [El May, Michele Veronique; El May, Ahmed] Fac Med Tunis, Unite Rech UR 07 08 01, Tunis, Tunisia.
C3 Centre de Biotechnologie de Borj Cedria; Universite de Carthage;
   Universite de Tunis-El-Manar; Faculte de Medecine de Tunis (FMT)
RP Charradi, K (corresponding author), Ctr Biotechnol Borj Cedria, Lab Subst Bioact LSBA, BP 901, Hammam Lif 2050, Tunisia.
EM charradi3@yahoo.com
RI Charradi, Kamel/AAR-8778-2021; ELKAHOUI, Salem/AAR-6542-2021
OI ELKAHOUI, SALEM/0000-0001-5577-1011
CR [Anonymous], 2011, AG RESP LETT GRAS NO
   [Anonymous], 1974, HU BERGER METHODS EN
   Bagchi D, 2001, DRUG EXP CLIN RES, V27, P3
   Batista MN, 2006, BIOL TRACE ELEM RES, V112, P1, DOI 10.1385/BTER:112:1:1
   Bebe FN, 2009, BIOL TRACE ELEM RES, V129, P200, DOI 10.1007/s12011-008-8289-2
   Bettaieb I, 2011, J SCI FOOD AGR, V91, P2100, DOI 10.1002/jsfa.4513
   Bladé C, 2010, MOL NUTR FOOD RES, V54, P37, DOI 10.1002/mnfr.200900476
   Bobulescu IA, 2010, CURR OPIN NEPHROL HY, V19, P393, DOI 10.1097/MNH.0b013e32833aa4ac
   Charradi K, 2012, NEUROCHEM RES, V37, P2004, DOI 10.1007/s11064-012-0821-2
   Charradi K, 2011, CARDIOVASC TOXICOL, V11, P28, DOI 10.1007/s12012-010-9101-z
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Chen J, 2007, NEPHROL DIAL TRANSPL, V22, P1100, DOI 10.1093/ndt/gfl759
   Chung HW, 2012, NEPHROL DIAL TRANSPL, V27, P2213, DOI 10.1093/ndt/gfr613
   COCKCROFT DW, 1976, NEPHRON, V16, P31, DOI 10.1159/000180580
   DRAPER HH, 1990, METHOD ENZYMOL, V186, P421
   ELLMAN GL, 1959, ARCH BIOCHEM BIOPHYS, V82, P70, DOI 10.1016/0003-9861(59)90090-6
   Erdely A, 2004, DIABETOLOGIA, V47, P1672, DOI 10.1007/s00125-004-1509-1
   Ferruzzi MG, 2009, J ALZHEIMERS DIS, V18, P113, DOI 10.3233/JAD-2009-1135
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   GREEN LC, 1982, ANAL BIOCHEM, V126, P131, DOI 10.1016/0003-2697(82)90118-X
   HARTREE EF, 1972, ANAL BIOCHEM, V48, P422, DOI 10.1016/0003-2697(72)90094-2
   KAKINUMA K, 1979, J BIOCHEM, V86, P87
   Kambham N, 2001, KIDNEY INT, V59, P1498, DOI 10.1046/j.1523-1755.2001.0590041498.x
   KASISKE BL, 1988, KIDNEY INT, V33, P667, DOI 10.1038/ki.1988.51
   Khanal RC, 2009, J FOOD SCI, V74, pH174, DOI 10.1111/j.1750-3841.2009.01221.x
   Król E, 2011, BIOL TRACE ELEM RES, V144, P885, DOI 10.1007/s12011-011-9048-3
   Leardi A, 1998, BRIT J HAEMATOL, V102, P746, DOI 10.1046/j.1365-2141.1998.00834.x
   LEVINE RL, 1990, METHOD ENZYMOL, V186, P464
   Listenberger LL, 2003, P NATL ACAD SCI USA, V100, P3077, DOI 10.1073/pnas.0630588100
   MISRA HP, 1972, J BIOL CHEM, V247, P3170
   Mohanasundari M., 2005, Indian Journal of Experimental Biology, V43, P356
   NAKAMURA W, 1974, BIOCHIM BIOPHYS ACTA, V358, P251, DOI 10.1016/0005-2744(74)90455-0
   Nandakumar V, 2008, CANCER LETT, V269, P378, DOI 10.1016/j.canlet.2008.03.049
   Nicholson AC, 2000, ANN NY ACAD SCI, V902, P128
   Pan SY, 2006, CANCER EPIDEM BIOMAR, V15, P2453, DOI 10.1158/1055-9965.EPI-06-0616
   Salem NA, 2011, RENAL FAILURE, V33, P824, DOI 10.3109/0886022X.2011.601832
   Schaffer JE, 2003, CURR OPIN LIPIDOL, V14, P281, DOI 10.1097/00041433-200306000-00008
   Serrano J, 2009, MOL NUTR FOOD RES, V53, pS310, DOI 10.1002/mnfr.200900039
   Shetty AK, 2005, PLANT FOOD HUM NUTR, V60, P109, DOI 10.1007/s11130-005-6837-x
   STERN J, 1957, CLIN CHIM ACTA, V2, P576, DOI 10.1016/0009-8981(57)90063-3
   Unger RH, 2002, ANNU REV MED, V53, P319, DOI 10.1146/annurev.med.53.082901.104057
   Unger RH, 2001, FASEB J, V15, P312, DOI 10.1096/fj.00-0590
   Wahba IM, 2007, CLIN J AM SOC NEPHRO, V2, P550, DOI 10.2215/CJN.04071206
   Wang YF, 2011, ADV NUTR, V2, P129, DOI 10.3945/an.110.000273
   Wei RB, 2012, AM J MED SCI, V343, P452, DOI 10.1097/MAJ.0b013e31823315f7
   Weinberg JM, 2006, KIDNEY INT, V70, P1560, DOI 10.1038/sj.ki.5001834
   Worthington Biochemical Corporation, 1977, WORTHINGTON ENZYME M, P74
NR 47
TC 22
Z9 27
U1 0
U2 22
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD MAR
PY 2013
VL 38
IS 3
BP 259
EP 267
DI 10.1139/apnm-2012-0416
PG 9
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA 116CP
UT WOS:000316860500005
PM 23537016
DA 2025-06-11
ER

PT J
AU Gulliver, WP
   Randell, S
   Gulliver, S
   Macdonald, D
   Gregory, V
   Nagle, S
   Chambenoit, O
AF Gulliver, Wayne P.
   Randell, Shane
   Gulliver, Susanne
   Macdonald, Don
   Gregory, Valerie
   Nagle, Sean
   Chambenoit, Olivier
TI An Investigation of Comorbid Disease and Health Service Utilization
   Among Patients With Moderate to Severe Psoriasis in Newfoundland and
   Labrador
SO JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
LA English
DT Article
DE psoriasis; comorbidity; cardiovascular; inflammatory; depression;
   biologic
ID QUALITY-OF-LIFE; LONG-TERM PROGNOSIS; ETANERCEPT; EFALIZUMAB; ARTHRITIS;
   THERAPY; BURDEN; NEED
AB Psoriasis is an inflammatory skin condition affecting 2% to 3% of the population and is associated with several comorbidities, including cardiovascular disease, depression, inflammatory bowel disease, metabolic syndrome, mood disorder, psoriatic arthritis, and weight gain. Psoriasis is treated with a number of topical and systemic therapies, including biologic drugs that directly target proinflammatory cytokines. This cross-sectional retrospective study investigated comorbid conditions reported in the Newfoundland and Labrador psoriasis population, outcomes associated with therapeutic treatment, and use of health care resources. Of the psoriasis comorbidities investigated, psoriatic arthritis was significantly associated with the use of biologic therapy while a failure to respond to biologics was associated with a higher incidence of cardiovascular disease. Patients responsive to biologic treatment had fewer hospital stays than patients treated with other therapies. Our results suggest that biologic therapies have a cardioprotective effect and reduce the number of hospital visits in patients whose symptoms are responsive to treatment.
C1 [Gulliver, Wayne P.; Randell, Shane; Gulliver, Susanne] Newlab Clin Res, 187 LeMarchant Rd, St John, NB AIC 2H5, Canada.
   [Gulliver, Wayne P.] Mem Univ Newfoundland, Fac Med, Dept Med, St John, NB, Canada.
   [Macdonald, Don] Newfoundland & Labrador Ctr Hlth Informat, St John, NF, Canada.
   [Gregory, Valerie] Novartis Pharmaceut Canada, Dorval, PQ, Canada.
   [Nagle, Sean] Novartis Latin Amer Serv, Miami, FL USA.
   [Chambenoit, Olivier] Novartis Pharmaceut, E Hanover, NJ USA.
C3 Memorial University Newfoundland; Novartis; Novartis USA
RP Randell, S (corresponding author), Newlab Clin Res, 187 LeMarchant Rd, St John, NB AIC 2H5, Canada.
EM srandell@newlabresearch.com
RI Gulliver, Professor Wayne/ACM-2713-2022; Gulliver, Susanne R/O-5491-2018
OI Gulliver, Susanne R/0000-0002-3886-8740; Gulliver,
   Wayne/0000-0002-5990-232X; Randell, Shane/0009-0001-4314-240X
CR Abuabara K, 2011, BRIT J DERMATOL, V165, P1066, DOI 10.1111/j.1365-2133.2011.10525.x
   Armstrong EJ, 2013, J AM HEART ASSOC, V2, DOI 10.1161/JAHA.113.000062
   Balkrishnan R, 2005, MED CARE, V43, P517, DOI 10.1097/01.mlr.0000166617.68751.5f
   Bernstein CN, 2005, GASTROENTEROLOGY, V129, P827, DOI 10.1053/j.gastro.2005.06.021
   Canadian Psoriasis Guidelines Committee, 2009, Canadian guidelines for the management of plaque psoriasis
   Crown WH, 2004, CURR MED RES OPIN, V20, P1929, DOI 10.1185/030079904X15192
   de Korte J, 2004, J INVEST DERM SYMP P, V9, P140, DOI 10.1046/j.1087-0024.2003.09110.x
   Driessen RJB, 2008, BRIT J DERMATOL, V159, P460, DOI 10.1111/j.1365-2133.2008.08669.x
   Gelfand JM, 2004, J AM ACAD DERMATOL, V51, P704, DOI 10.1016/j.jaad.2004.04.014
   Gulliver W, 2008, BRIT J DERMATOL, V159, P2, DOI 10.1111/j.1365-2133.2008.08779.x
   Gulliver WP, 2016, J CUTAN MED SURG, V20, P536, DOI 10.1177/1203475416650430
   Gulliver WP, 2011, J CUTAN MED SURG, V15, P37, DOI 10.2310/7750.2010.10013
   Hemminki K, 2009, ARTHRITIS RHEUM, V60, P661, DOI 10.1002/art.24328
   Lin HC, 2012, J DERMATOL TREAT, V23, P196, DOI 10.3109/09546634.2010.544708
   Menter A, 2008, J AM ACAD DERMATOL, V58, P826, DOI 10.1016/j.jaad.2008.02.039
   Nall L, 1999, CUTIS, V64, P323
   National Psoriasis Foundation, PSOR
   Poulin Y, 2005, J CUTAN MED SURG, V9, P10, DOI 10.1007/s10227-006-0102-2
   Schoffski Oliver, 2007, J Dtsch Dermatol Ges, V5, P209, DOI 10.1111/j.1610-0387.2007.06240.x
   Shapiro J, 2007, J AM ACAD DERMATOL, V56, P629, DOI 10.1016/j.jaad.2006.09.017
   Sommer DM, 2006, ARCH DERMATOL RES, V298, P321, DOI 10.1007/s00403-006-0703-z
   Wahl A, 2000, J AM ACAD DERMATOL, V43, P803, DOI 10.1067/mjd.2000.107501
   Weinberg JM, 2003, CLIN THER, V25, P2487, DOI 10.1016/S0149-2918(03)80313-2
NR 23
TC 3
Z9 3
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1203-4754
EI 1615-7109
J9 J CUTAN MED SURG
JI J. Cutan. Med. Surg.
PD JAN-FEB
PY 2019
VL 23
IS 1
BP 29
EP 34
DI 10.1177/1203475418791114
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA HH6YI
UT WOS:000455876900003
PM 30041544
DA 2025-06-11
ER

PT J
AU Phillips, OR
   Onopa, AK
   Zaiko, YV
   Singh, MK
AF Phillips, Owen R.
   Onopa, Alexander K.
   Zaiko, Yevgeniya V.
   Singh, Manpreet K.
TI Insulin resistance is associated with smaller brain volumes in a
   preliminary study of depressed and obese children
SO PEDIATRIC DIABETES
LA English
DT Article
DE brain; depression; insulin; metabolism; obesity
ID METABOLIC SYNDROME; DIABETES-MELLITUS; CEREBRAL-CORTEX; GRAY-MATTER;
   DISORDERS; PREVALENCE; SYMPTOMS; YOUTH; RISK
AB Objective: During childhood, the brain can consume up to 65% of total calories, and a steady supply of the brain's main fuel glucose needs to be maintained. Although the brain itself is not dependent on insulin for the uptake of glucose, insulin plays an important role in energy homeostasis. Thus, the risk for insulin resistance during brain development may negatively impact the whole brain volume.
   Methods: We investigated the link between the insulin resistance and the whole brain volume as measured by structural Magnetic resonance imaging (MRI) in 46 unmedicated depressed and overweight youths between the ages of 9 and 17 years.
   Results: Smaller whole brain volumes were associated with insulin resistance independent of age, sex, depression severity, body mass index, socioeconomic status, Tanner Stage, and Intelligence quotient (IQ) (r = 0.395, P = .014)
   Conclusions: There may be a significant cost for developing insulin resistance on the developing brain. Disentangling the precise relationship between the insulin resistance and the developing brain is critical.
C1 [Phillips, Owen R.; Onopa, Alexander K.; Zaiko, Yevgeniya V.; Singh, Manpreet K.] Stanford Univ, Sch Med, Stanford Pediat Mood Disorders Program, Dept Psychiat,Div Child & Adolescent Psychiat, Stanford, CA 94305 USA.
C3 Stanford University
RP Phillips, OR (corresponding author), Stanford Pediat Mood Disorders Program, Div Child & Adolescent Psychiat, 401 Quarry Rd, Stanford, CA 94305 USA.
EM Owenp@Stanford.edu
RI Phillips, Owen/J-3651-2017; Singh, Manpreet/L-1068-2014
OI Phillips, Owen/0000-0002-5391-707X; Singh, Manpreet/0000-0002-4373-3293
FU National Institute of Mental Health [R01MH106581]
FX National Institute of Mental Health, Grant/Award Number: R01MH106581
CR Al Mamun A, 2007, OBESITY, V15, P3097, DOI 10.1038/oby.2007.369
   [Anonymous], 2017, National Diabetes Statistics Report
   Banks WA, 2004, EUR J PHARMACOL, V490, P5, DOI 10.1016/j.ejphar.2004.02.040
   Banks WA, 2012, PHARMACOL THERAPEUT, V136, P82, DOI 10.1016/j.pharmthera.2012.07.006
   Black JM, 2012, NEUROIMAGE, V59, P3021, DOI 10.1016/j.neuroimage.2011.10.024
   Brown AE, 2016, CURR CARDIOL REP, V18, DOI 10.1007/s11886-016-0755-4
   Buhl ES, 2010, AM J PHYSIOL-ENDOC M, V298, pE920, DOI 10.1152/ajpendo.00606.2009
   Cai ZJ, 1999, WHO TECH REP SER, V887, P1
   Chen YC, 2014, DIABETES CARE, V37, P1689, DOI 10.2337/dc13-2127
   DEFRONZO RA, 1979, AM J PHYSIOL, V237, pE214
   Ernersson Å, 2010, EAT BEHAV, V11, P247, DOI 10.1016/j.eatbeh.2010.05.005
   Espeland MA, 2013, DIABETES CARE, V36, P90, DOI 10.2337/dc12-0555
   Fischl B, 2000, P NATL ACAD SCI USA, V97, P11050, DOI 10.1073/pnas.200033797
   Ford ES, 2008, DIABETES CARE, V31, P587, DOI 10.2337/dc07-1030
   Guallar-Castillón P, 2014, REV ESP CARDIOL, V67, P367, DOI [10.1016/j.rec.2013.08.014, 10.1016/j.recesp.2013.08.014]
   HAVRANKOVA J, 1979, J CLIN INVEST, V64, P636, DOI 10.1172/JCI109504
   Henderson M, 2011, DIABETES METAB, V37, P72, DOI 10.1016/j.diabet.2010.06.008
   Hollingshead A.B., 1975, 4 FACTOR INDEX SOCIA
   Kapogiannis D, 2015, FASEB J, V29, P589, DOI 10.1096/fj.14-262048
   Kessler RC, 2013, ANNU REV PUBL HEALTH, V34, P119, DOI 10.1146/annurev-publhealth-031912-114409
   Kullmann S, 2015, J NEUROENDOCRINOL, V27, P419, DOI 10.1111/jne.12254
   Kullmann S, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-01907-w
   Kullmann S, 2016, PHYSIOL REV, V96, P1169, DOI 10.1152/physrev.00032.2015
   Kuzawa CW, 2014, P NATL ACAD SCI USA, V111, P13010, DOI 10.1073/pnas.1323099111
   Last D, 2007, DIABETES CARE, V30, P1193, DOI 10.2337/dc06-2052
   MARSHALL WA, 1970, ARCH DIS CHILD, V45, P13, DOI 10.1136/adc.45.239.13
   Matsuda M, 1999, DIABETES CARE, V22, P1462, DOI 10.2337/diacare.22.9.1462
   Mazaika PK, 2016, DIABETES, V65, P476, DOI 10.2337/db15-1242
   McElroy SL, 2004, J CLIN PSYCHIAT, V65, P634
   McElroy SL, 2004, J CLIN PSYCHIAT, V65, P730
   McIntyre RS, 2010, ADV THER, V27, P63, DOI 10.1007/s12325-010-0011-z
   McIntyre RS, 2009, CURR DIABETES REP, V9, P51, DOI 10.1007/s11892-009-0010-0
   Merikangas KR, 2010, J AM ACAD CHILD PSY, V49, P980, DOI 10.1016/j.jaac.2010.05.017
   Morris JK, 2014, NEUROSCIENCE, V270, P139, DOI 10.1016/j.neuroscience.2014.04.006
   Mullins RJ, 2017, FRONT AGING NEUROSCI, V9, DOI 10.3389/fnagi.2017.00118
   Neef M, 2013, BEST PRACT RES CL EN, V27, P229, DOI 10.1016/j.beem.2013.02.007
   Pott W, 2010, J DEV BEHAV PEDIATR, V31, P635, DOI 10.1097/DBP.0b013e3181f178eb
   Prasad D S, 2012, J Cardiovasc Dis Res, V3, P204, DOI 10.4103/0975-3583.98895
   Raichle ME, 2002, P NATL ACAD SCI USA, V99, P10237, DOI 10.1073/pnas.172399499
   Rasgon NL, 2011, NEUROBIOL AGING, V32, P1942, DOI 10.1016/j.neurobiolaging.2009.12.005
   Rasgon NL, 2010, THESCIENTIFICWORLDJO, V10, P321, DOI 10.1100/tsw.2010.32
   Roglic G, 2016, Global report on psoriasis
   Ryan JP, 2012, PSYCHOSOM MED, V74, P476, DOI 10.1097/PSY.0b013e31824d0865
   Ryu SY, 2014, NEUROLOGY, V82, P1862, DOI 10.1212/WNL.0000000000000452
   Sakul H, 1997, AM J HUM GENET, V60, P651
   Salat DH, 2004, CEREB CORTEX, V14, P721, DOI 10.1093/cercor/bhh032
   Schneider AL, 2017, DIABETES CARE, V40, P1514, DOI 10.2337/dc17-1185
   Shomaker LB, 2011, DIABETES CARE, V34, P2458, DOI 10.2337/dc11-1131
   Sidhu S., 2000, Endotext
   Soczynska JK, 2011, NEUROMOL MED, V13, P93, DOI 10.1007/s12017-010-8140-8
   The Psychological Corporation, 1999, WECHSLER ABBREVIATED
   Wilcox Gisela, 2005, Clin Biochem Rev, V26, P19
   Willette AA, 2013, DIABETES CARE, V36, P443, DOI 10.2337/dc12-0922
   World Health Organization, 2017, WHOMSDMER20172
   World Health Organization, 2020, DEPRESSION
NR 55
TC 11
Z9 11
U1 1
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1399-543X
EI 1399-5448
J9 PEDIATR DIABETES
JI Pediatr. Diabetes
PD AUG
PY 2018
VL 19
IS 5
BP 892
EP 897
DI 10.1111/pedi.12672
PG 6
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Pediatrics
GA GL4PO
UT WOS:000437136500005
PM 29569318
OA Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Lu, Y
   Wang, PX
   Lan, N
   Kong, F
   Abdumijit, A
   Tu, SY
   Li, YT
   Yuan, WZ
AF Lu, Ying
   Wang, Pinxiu
   Lan, Ning
   Kong, Fei
   Abdumijit, Awaguli
   Tu, Shiyan
   Li, Yanting
   Yuan, Wenzhen
TI Metabolic Syndrome Predicts Response to Neoadjuvant Chemotherapy in
   Breast Cancer
SO FRONTIERS IN ONCOLOGY
LA English
DT Article
DE breast cancer; metabolic syndrome; neoadjuvant chemotherapy; efficacy
   prediction; MP grading; RECIST criteria
ID RECEIVING NEOADJUVANT; LACTATE-DEHYDROGENASE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; URIC-ACID; OBESITY; IMPACT; SURVIVAL; CELLS
AB PurposeThis research investigated the predictive role of metabolic syndrome (MetS) in breast cancer neoadjuvant chemotherapy (BCNACT) response. MethodsOne hundred fifty primary breast cancer (BC) patients who underwent neoadjuvant chemotherapy (NACT) were included retrospectively. MetS, MetS components [waist circumference (WC), fasting blood glucose (FBG), blood pressure, triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C)], serum lipid, and other MetS-related laboratory indicators within two weeks before BCNACT were evaluated. Univariate, multivariate, and subgroup analyses were performed to determine the predictors of BCNACT pathologic complete response (pCR), clinical response, and pathologic response. The effectiveness of the model was evaluated via receiver operating characteristic curve (ROC) and calibration curve. External validation was performed through 135 patients. ResultsUnivariate analysis revealed that MetS before BCNACT predicted poor BCNACT response (pCR, P = 0.003; clinical response, P = 0.033; pathologic response, P < 0.001). Multivariate analysis confirmed that MetS before BCNACT predicted lower pCR rate (P = 0.041). Subgroup analysis showed that this relationship was significant in estrogen receptor (ER) (-) (RR = 0.266; 95% CI, 0.074-0.954), human epidermal growth factor 2 (HER2) (-) (RR = 0.833; 95% CI, 0.740-0.939) and TNBC (RR = 0.833; 95% CI, 0.636-0.995). Multivariate analysis of external validation confirmed that pretreatment MetS was associated with a lower pCR rate (P = 0.003), and subgroup analysis also confirmed that this relationship had significant statistical differences in ER (-), HER2 (-), and TNBC subgroups. ConclusionsMetS before BCNACT predicted a lower pCR rate. Intervention on MetS status, especially in ER (-), HER2 (-), and TNBC subgroups, is expected to improve the response rate of BCNACT further.
C1 [Lu, Ying; Wang, Pinxiu; Lan, Ning; Kong, Fei; Abdumijit, Awaguli; Tu, Shiyan; Li, Yanting] Lanzhou Univ, Sch Clin Med 1, Lanzhou, Peoples R China.
   [Yuan, Wenzhen] Lanzhou Univ, Dept Oncol, Hosp 1, Lanzhou, Peoples R China.
C3 Lanzhou University; Lanzhou University
RP Yuan, WZ (corresponding author), Lanzhou Univ, Dept Oncol, Hosp 1, Lanzhou, Peoples R China.
EM yuanwzh@lzu.edu.cn
RI Kong, Fei/KIB-6351-2024; 袁, 文臻/JRX-2086-2023
CR Adams SC, 2016, BREAST CANCER RES TR, V158, P497, DOI 10.1007/s10549-016-3900-2
   Alan O, 2020, WORLD J SURG ONCOL, V18, DOI 10.1186/s12957-020-02019-y
   Arici S, 2020, CURR PROB CANCER, V44, DOI 10.1016/j.currproblcancer.2019.05.007
   Bear HD, 2006, J CLIN ONCOL, V24, P2019, DOI 10.1200/JCO.2005.04.1665
   Cao MD, 2012, BMC CANCER, V12, DOI 10.1186/1471-2407-12-39
   de Groot S, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-16138-3
   de Groot S, 2016, BREAST CANCER RES, V18, DOI 10.1186/s13058-015-0663-3
   Dennison JB, 2013, CLIN CANCER RES, V19, P3703, DOI 10.1158/1078-0432.CCR-13-0623
   Dieli-Conwright CM, 2016, CANCER-AM CANCER SOC, V122, P2646, DOI 10.1002/cncr.30104
   Dong SW, 2021, FRONT ONCOL, V11, DOI 10.3389/fonc.2021.629666
   Duggan C, 2011, J CLIN ONCOL, V29, P32, DOI 10.1200/JCO.2009.26.4473
   Eisenhauer EA, 2009, EUR J CANCER, V45, P228, DOI 10.1016/j.ejca.2008.10.026
   Erbes T, 2016, CLIN BREAST CANCER, V16, pE119, DOI 10.1016/j.clbc.2016.02.018
   Fasshauer M, 2003, DIABETOLOGIA, V46, P1594, DOI 10.1007/s00125-003-1228-z
   Fontanella C, 2015, BREAST CANCER RES TR, V150, P127, DOI 10.1007/s10549-015-3287-5
   Furukawa S., 2004, Journal of Clinical Investigation, V114, P1752, DOI 10.1172/JCI21625
   Goodwin PJ, 2012, J CLIN ONCOL, V30, P164, DOI 10.1200/JCO.2011.36.2723
   Graziano V, 2019, BREAST, V44, P33, DOI 10.1016/j.breast.2018.12.014
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Healy LA, 2010, CLIN ONCOL-UK, V22, P281, DOI 10.1016/j.clon.2010.02.001
   Heys SD, 1998, INT J ONCOL, V12, P221
   Hilvo M, 2014, INT J CANCER, V134, P1725, DOI 10.1002/ijc.28491
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Hu DA, 2017, EBIOMEDICINE, V15, P73, DOI 10.1016/j.ebiom.2016.12.004
   Johnson RJ, 2013, DIABETES, V62, P3307, DOI 10.2337/db12-1814
   Johnson RJ, 2005, J AM SOC NEPHROL, V16, P1909, DOI 10.1681/ASN.2005010063
   Kaufmann M, 2007, ANN ONCOL, V18, P1927, DOI 10.1093/annonc/mdm201
   Le A, 2010, P NATL ACAD SCI USA, V107, P2037, DOI 10.1073/pnas.0914433107
   Litton JK, 2008, J CLIN ONCOL, V26, P4072, DOI 10.1200/JCO.2007.14.4527
   Lu ZH, 2021, J CLIN ONCOL, V39, P748, DOI 10.1200/JCO.20.01254
   Ogston KN, 2003, BREAST, V12, P320, DOI 10.1016/S0960-9776(03)00106-1
   Protani M, 2010, BREAST CANCER RES TR, V123, P627, DOI 10.1007/s10549-010-0990-0
   Qu FL, 2020, J BREAST CANCER, V23, P246, DOI 10.4048/jbc.2020.23.e32
   Romero A, 2013, ANN ONCOL, V24, P655, DOI 10.1093/annonc/mds493
   Sahin AB, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-94184-7
   Siegel RL, 2021, CA-CANCER J CLIN, V71, P7, DOI 10.3322/caac.21654
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Stebbing J, 2012, ANN ONCOL, V23, P860, DOI 10.1093/annonc/mdr347
   Tong YW, 2019, ONCOTARGETS THER, V12, P3977, DOI 10.2147/OTT.S194981
   Xiang YJ, 2020, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00905
   Zeng L, 2016, ENDOCR-RELAT CANCER, V23, P125, DOI 10.1530/ERC-15-0507
   Zeng L, 2010, ENDOCR-RELAT CANCER, V17, P539, DOI 10.1677/ERC-09-0221
   Zhu Q, 2021, BREAST CANCER RES TR, V188, P615, DOI 10.1007/s10549-021-06239-y
NR 43
TC 8
Z9 8
U1 0
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD JUL 1
PY 2022
VL 12
AR 899335
DI 10.3389/fonc.2022.899335
PG 15
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 3B6EP
UT WOS:000828032000001
PM 35847887
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nowrouzi-Sohrabi, P
   Hassanipour, S
   Sisakht, M
   Daryabeygi-Khotbehsara, R
   Savardashtaki, A
   Fathalipour, M
AF Nowrouzi-Sohrabi, Peyman
   Hassanipour, Soheil
   Sisakht, Mohsen
   Daryabeygi-Khotbehsara, Reza
   Savardashtaki, Amir
   Fathalipour, Mohammad
TI The effectiveness of pistachio on glycemic control and insulin
   sensitivity in patients with type 2 diabetes, prediabetes and metabolic
   syndrome: A systematic review and meta-analysis
SO DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
LA English
DT Review
DE Pistachio nuts; Type 2 diabetes; Prediabetes; Metabolic syndrome; Review
ID HOMEOSTASIS MODEL ASSESSMENT; MONOUNSATURATED FATTY-ACIDS; ENDOTHELIAL
   FUNCTION; GLUCOSE-METABOLISM; OXIDATIVE STRESS; NUT CONSUMPTION;
   BODY-WEIGHT; RESISTANCE; INFLAMMATION; RISK
AB Background and aims: Pistachio nuts have been considered to improve dysglycemia. However, there are controversial results. This systematic review and meta-analysis carried out to evaluate the effects of pistachio nuts on glycemic control and insulin sensitivity in patients with type 2 diabetes mellitus (T2DM), prediabetes, and metabolic syndrome.
   Methods: Medline/PubMed, ProQuest, Web of Knowledge, Scopus, Cochrane library, and ScienceDirect were systematically searched to find randomized controlled trials (RCTs). Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) checklist was used to conduct the study.
   Results: Six RCTs were included in the review. Treatment with pistachio nuts exerted a significant reduction in fasting blood glucose (FBG) level (OR = 1.7, 95% CI; 1.2e2.4, P = 0.002, I-2 = 0.0%, P = 0.731) and homeostasis model assessment of insulin resistance (HOMA-IR) index (OR = 1.5, 95% CI; 1.0-2.4, P = 0.043, I-2 = 0.0%, P = 0.617), but no significant improvement was observed in regard to hemoglobin A1c (HbA1c) level (OR = 1.4, 95% CI; 0.9-2.1 P = 0.089, I-2 = 0.0%, P = 0.957) and fasting plasma insulin (FPI) level (OR = 1.3, 95% CI; 0.9-1.9, P = 0.133, I-2 = 0.0%, P = 0.776).
   Conclusions: Pistachio nuts might cause a significant reduction in FBG and HOMA-IR, although HbA1c and FPI might not significantly improve in patients suffering from or at risk of T2DM. (c) 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.
C1 [Nowrouzi-Sohrabi, Peyman; Sisakht, Mohsen] Shiraz Univ Med Sci, Student Res Comm, Shiraz, Iran.
   [Hassanipour, Soheil] Guilan Univ Med Sci, Gastrointestinal & Liver Dis Res Ctr, Rasht, Iran.
   [Daryabeygi-Khotbehsara, Reza] Deakin Univ, Inst Phys Act & Nutr, Geelong, Vic, Australia.
   [Savardashtaki, Amir] Shiraz Univ Med Sci, Fac Adv Med Sci & Technol, Dept Med Biotechnol, Shiraz, Iran.
   [Fathalipour, Mohammad] Hormozgan Univ Med Sci, Fac Pharm, Dept Pharmacol & Toxicol, Bandar Abbas, Iran.
   [Fathalipour, Mohammad] Hormozgan Univ Med Sci, Endocrinol & Metab Res Ctr, Bandar Abbas, Iran.
C3 Shiraz University of Medical Science; Guilan University of Medical
   Sciences; Deakin University; Shiraz University of Medical Science
RP Fathalipour, M (corresponding author), Hormozgan Univ Med Sci, Fac Pharm, Dept Pharmacol & Toxicol, Bandar Abbas, Iran.
EM M.fathalipour@Hums.ac.ir
RI Daryabeygi-Khotbehsara, Reza/AAK-1110-2021; Hassanipour,
   Soheil/JAC-9443-2023; Savardashtaki, Amir/M-6041-2018; Daryabeygi,
   Reza/H-6122-2013; Fathalipour, Mohammad/L-9204-2016
OI Daryabeygi, Reza/0000-0003-4064-978X; Fathalipour,
   Mohammad/0000-0002-4568-7024; Nowrouzi-Sohrabi,
   Peyman/0000-0002-9720-2025
CR Akbaraly TN, 2008, DIABETES CARE, V31, P1355, DOI 10.2337/dc07-2113
   Aleem S, 2018, RECENT PATENTS INFLA, V12, P78, DOI 10.2174/1872213X12666180717165331
   Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
   Bao Y, 2013, NEW ENGL J MED, V369, P2001, DOI 10.1056/NEJMoa1307352
   Borén J, 2013, J INTERN MED, V274, P25, DOI 10.1111/joim.12071
   Bulló M, 2015, BRIT J NUTR, V113, pS79, DOI 10.1017/S0007114514003250
   Czech MP, 2017, NAT MED, V23, P804, DOI 10.1038/nm.4350
   Damavandi RD, 2013, J RES MED SCI, V18, P314
   Egan A.M., 2019, Science Direct, V47, P1, DOI [10.1016/j.mpmed.2018.10.002, DOI 10.1016/J.MPMED.2018.10.002]
   Farmanfarma KK, 2019, DIABETES METAB SYND, V13, P792, DOI 10.1016/j.dsx.2018.11.055
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gulati S, 2014, NUTRITION, V30, P192, DOI 10.1016/j.nut.2013.08.005
   Hernández-Alonso P, 2014, DIABETES CARE, V37, P3098, DOI 10.2337/dc14-1431
   Ighbariya A, 2017, J CLIN RES PEDIATR E, V9, P49, DOI 10.4274/jcrpe.2017.S005
   Jenkins DJA, 2008, J NUTR, V138, p1752S, DOI 10.1093/jn/138.9.1752S
   Kasliwal RR, 2015, NUTRITION, V31, P678, DOI 10.1016/j.nut.2014.10.019
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kendall CWC, 2014, EUR J CLIN NUTR, V68, P370, DOI 10.1038/ejcn.2013.275
   Kendall CWC, 2011, EUR J CLIN NUTR, V65, P696, DOI 10.1038/ejcn.2011.12
   Kochar J, 2010, EUR J CLIN NUTR, V64, P75, DOI 10.1038/ejcn.2009.121
   Li SC, 2011, METABOLISM, V60, P474, DOI 10.1016/j.metabol.2010.04.009
   Li ZP, 2010, J AM COLL NUTR, V29, P198, DOI 10.1080/07315724.2010.10719834
   Ma YY, 2010, DIABETES CARE, V33, P227, DOI 10.2337/dc09-1156
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Moon JH, 2010, LIPIDS, V45, P1109, DOI 10.1007/s11745-010-3475-3
   Nanaware M, 2017, INT J MED SCI PUBL H, V6, P239
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Ogurtsova K, 2017, DIABETES RES CLIN PR, V128, P40, DOI 10.1016/j.diabres.2017.03.024
   Okita K, 2013, ENDOCR J, V60, P283
   Parham Mahmoud, 2014, Rev Diabet Stud, V11, P190, DOI 10.1900/RDS.2014.11.190
   Rajaram S, 2006, BRIT J NUTR, V96, pS79, DOI 10.1017/BJN20061867
   Ros E, 2010, NUTRIENTS, V2, P652, DOI 10.3390/nu2070652
   Ros E, 2009, AM J CLIN NUTR, V89, pS1649, DOI 10.3945/ajcn.2009.26736R
   Samuel VT, 2012, CELL, V148, P852, DOI 10.1016/j.cell.2012.02.017
   Sauder KA, 2015, METABOLISM, V64, P1521, DOI 10.1016/j.metabol.2015.07.021
   Schwingshackl L, 2011, ANN NUTR METAB, V58, P290, DOI 10.1159/000331214
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Tabák AG, 2012, LANCET, V379, P2279, DOI 10.1016/S0140-6736(12)60283-9
   UNICEF, 2015, WHO Guidelines Approved by the Guidelines Review Committee. Pregnancy, Childbirth
   Wang X, 2012, NUTR J, V11, DOI 10.1186/1475-2891-11-20
   Wien MA, 2003, INT J OBESITY, V27, P1365, DOI 10.1038/sj.ijo.0802411
   Yaribeygi H, 2019, J CELL PHYSIOL, V234, P8152, DOI 10.1002/jcp.27603
   Zimmet P, 2016, NAT REV ENDOCRINOL, V12, P616, DOI 10.1038/nrendo.2016.105
NR 43
TC 18
Z9 19
U1 4
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-4021
EI 1878-0334
J9 DIABETES METAB SYND
JI Diabetes Metab. Syndr.-Clin. Res. Rev.
PD SEP-OCT
PY 2020
VL 14
IS 5
BP 1589
EP 1595
DI 10.1016/j.dsx.2020.07.052
PG 7
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA OG9KS
UT WOS:000582194300153
PM 32947760
DA 2025-06-11
ER

PT J
AU Kir, S
   Ekiz, K
   Alacam, H
   Turkel, R
   Koroglu, E
   Altintop, BL
AF Kir, S.
   Ekiz, K.
   Alacam, H.
   Turkel, R.
   Koroglu, E.
   Altintop, B. L.
TI THE ASSOCIATION BETWEEN PRO AND ANTI-INFLAMMATORY MARKERS WITH THE
   COMPONENTS OF METABOLIC SYNDROME
SO ACTA ENDOCRINOLOGICA-BUCHAREST
LA English
DT Article
DE Metabolic syndrome; inflammatory markers; abdominal obesity;
   hypertension; hyperglycemia; hypertriglyceridemia
ID TUMOR-NECROSIS-FACTOR; ADIPOSE-TISSUE; INSULIN ACTION; ADHESION
   MOLECULES; ALPHA LEVELS; TNF-ALPHA; ADIPONECTIN; INTERLEUKIN-6;
   INFLAMMATION; OBESE
AB Objectives. Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that is linked with increased circulating markers of oxidative stress and low-grade inflammation. The link between inflammation and MetS is not yet fully understood. We aim to evaluate the relationship between the levels of pro and anti-inflammatory markers such as apolipoprotein A1 (Apo-A1), apolipoprotein B (Apo-B), interleukin (IL) 6, tumor necrosis factor alpha (TNF-alpha), fibrinogen and complement component 3 (C3) and adiponectin and MetS/MetS components.
   Methods. This study was a case-control study conducted in an outpatient internal medicine clinic of the Ondokuz Mayis University Internal Medicine Department. A total of 108 subjects (59 female, 49 male) who were not under any dietary restrictions and older than 17 years were selected and divided into two groups (54 with MetS and 54 healthy controls).
   Results. Increased levels of IL-6, C3 and Apo-B/Apo-A1 ratios and decreased levels of Apo-A1 and TNF-alpha (except in patients with hypertriglyceridemia) were detected in the MetS group. Apo-A1 and TNF-alpha exhibited decreased levels, and IL-6, fibrinogen, C3 and Apo-B levels and Apo-B/Apo-A1 ratios increased as higher numbers of MetS criteria were met in the total study group.
   Conclusions. We found that inflammatory marker levels were not affected by an increased number of MetS criteria met in the MetS group although these levels increased in the control group with higher numbers of MetS components. The presence of a high number of MetS components does not have an additive pro-inflammatory contribution for subjects already diagnosed with MetS.
C1 [Kir, S.; Ekiz, K.; Turkel, R.; Koroglu, E.; Altintop, B. L.] Ondokuz Mayis Univ, Fac Med, Dept Internal Med, Samsun, Turkey.
   [Alacam, H.] Ondokuz Mayis Univ, Fac Med, Dept Biochem, Samsun, Turkey.
C3 Ondokuz Mayis University; Ondokuz Mayis University
RP Kir, S (corresponding author), Ondokuz Mayis Univ, Fac Med, Dept Internal Med, TR-55200 Atakum, Samsun, Turkey.
EM seherkr@yahoo.com
RI KIR, Seher/ABG-5244-2020
OI KIR, Seher/0000-0003-2835-1745
FU Ondokuz Mayis University scientific research fund
FX This research is supported by Ondokuz Mayis University scientific
   research fund.
CR Choi KM, 2004, DIABETES RES CLIN PR, V64, P99, DOI 10.1016/j.diabres.2003.10.007
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Esposito K, 2002, CIRCULATION, V106, P2067, DOI 10.1161/01.CIR.0000034509.14906.AE
   Fried SK, 1998, J CLIN ENDOCR METAB, V83, P847, DOI 10.1210/jc.83.3.847
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Gurrola-Díaz CM, 2009, J CLIN LAB ANAL, V23, P51, DOI 10.1002/jcla.20289
   Gustafson B, 2007, ARTERIOSCL THROM VAS, V27, P2276, DOI 10.1161/ATVBAHA.107.147835
   Jacques B., 1999, Tietz Textbook of Clinical Chemistry, V3rd, P541
   Kern PA, 2001, AM J PHYSIOL-ENDOC M, V280, pE745
   Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2548, DOI 10.1210/jc.2004-0395
   Koh KK, 2005, J AM COLL CARDIOL, V46, P1978, DOI 10.1016/j.jacc.2005.06.082
   Lee Yong-Ho, 2005, Curr Diab Rep, V5, P70
   Leinonen E, 2003, ATHEROSCLEROSIS, V166, P387, DOI 10.1016/S0021-9150(02)00371-4
   LIBBY P, 1995, CIRCULATION, V91, P2844, DOI 10.1161/01.CIR.91.11.2844
   Matsushita K, 2006, ARTERIOSCL THROM VAS, V26, P871, DOI 10.1161/01.ATV.0000208363.85388.8f
   Matsuzawa Y, 2004, ARTERIOSCL THROM VAS, V24, P29, DOI 10.1161/01.ATV.0000099786.99623.EF
   Moon YS, 2004, METABOLISM, V53, P863, DOI 10.1016/j.metabol.2004.02.007
   Nawrocki AR, 2004, CURR OPIN PHARMACOL, V4, P281, DOI 10.1016/j.coph.2004.03.003
   Nickenig G, 2004, CIRCULATION, V110, P1013, DOI 10.1161/01.CIR.0000139857.85424.45
   Oksjoki R, 2003, CURR OPIN LIPIDOL, V14, P477, DOI 10.1097/00041433-200310000-00008
   Rajala MW, 2003, ENDOCRINOLOGY, V144, P3765, DOI 10.1210/en.2003-0580
   Ryo M, 2004, CIRC J, V68, P975, DOI 10.1253/circj.68.975
   Salmenniemi U, 2004, CIRCULATION, V110, P3842, DOI 10.1161/01.CIR.0000150391.38660.9B
   Sierra-Johnson J, 2006, AM J CARDIOL, V98, P1369, DOI 10.1016/j.amjcard.2006.06.029
   Steppan CM, 2001, NATURE, V409, P307, DOI 10.1038/35053000
   Sutherland JP, 2004, METAB SYNDR RELAT D, V2, P82, DOI 10.1089/met.2004.2.82
   Trayhurn P, 2005, ACTA PHYSIOL SCAND, V184, P285, DOI 10.1111/j.1365-201X.2005.01468.x
   Van Guilder GP, 2006, OBESITY, V14, P2127, DOI 10.1038/oby.2006.248
   Vozarova B, 2001, OBES RES, V9, P414, DOI 10.1038/oby.2001.54
   Weyer C, 2002, ATHEROSCLEROSIS, V161, P233, DOI 10.1016/S0021-9150(01)00626-8
   Willerson JT, 2004, CIRCULATION, V109, P2, DOI 10.1161/01.CIR.0000129535.04194.38
   Yamauchi T, 2002, NAT MED, V8, P1288, DOI 10.1038/nm788
   Yu JG, 2002, DIABETES, V51, P2968, DOI 10.2337/diabetes.51.10.2968
   Yudkin JS, 2003, INT J OBESITY, V27, pS25, DOI 10.1038/sj.ijo.0802496
NR 34
TC 11
Z9 12
U1 0
U2 1
PU EDITURA ACAD ROMANE
PI BUCURESTI
PA CALEA 13 SEPTEMBRIE NR 13, SECTOR 5, BUCURESTI 050711, ROMANIA
SN 1841-0987
EI 1843-066X
J9 ACTA ENDOCRINOL-BUCH
JI Acta Endocrinol.
PD OCT-DEC
PY 2019
VL 15
IS 4
BP 430
EP 435
DI 10.4183/aeb.2019.430
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA LY2KH
UT WOS:000540348500003
PM 32377238
OA Green Published
DA 2025-06-11
ER

PT J
AU Simunovic, M
   Supe-Domic, D
   Karin, Z
   Degoricija, M
   Paradzik, M
   Bozic, J
   Unic, I
   Skrabic, V
AF Simunovic, Marko
   Supe-Domic, Daniela
   Karin, Zeljka
   Degoricija, Marina
   Paradzik, Martina
   Bozic, Josko
   Unic, Ivana
   Skrabic, Veselin
TI Serum catestatin concentrations are decreased in obese children and
   adolescents
SO PEDIATRIC DIABETES
LA English
DT Article
DE adolescents; catestatin; children; metabolic syndrome; obesity
ID INHIBITORY PEPTIDE CATESTATIN; CHROMOGRANIN-A FRAGMENT; CARDIOVASCULAR
   RISK-FACTORS; CATECHOLAMINE-RELEASE; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; PLASMA CATESTATIN; PUBERTAL CHANGES; BLOOD-PRESSURE;
   PREVALENCE
AB Background Catestatin is a chromogranin A-derived peptide with a wide spectrum of biological activities, such as inhibiting catecholamine release, decreasing blood pressure, stimulating histamine release, reducing beta-adrenergic stimulation, and regulating oxidative stress. Objectives The aims of our study were to determine serum catestatin concentrations in obese children and adolescents in regard to presence or absence of metabolic syndrome (MS) and to evaluate the possible relations between catestatin levels and other cardiovascular risk factors. Subjects Ninety-two obese subjects with a body mass index z score > 2, aged 10 to 18 years, and 39 healthy, normal weight controls were enrolled in the study. Methods Serum catestatin concentrations were measured using an enzyme-linked immunosorbent assay. Results Significantly lower serum catestatin concentrations were recorded in the group of obese subjects compared with a control group (10.03 +/- 5.05 vs 13.13 +/- 6.25 ng/mL, P = 0.004). Further analyses revealed significantly lower catestatin concentrations in the subgroup of obese patients with MS (9.02 +/- 4.3 vs 10.54 +/- 5.36 vs 13.13 +/- 6.25, P = 0.008). Serum catestatin concentrations were significantly negatively correlated with diastolic blood pressure (r = -0.253, P = 0.014), homeostatic model assessment of insulin resistance (r = -0.215, P = 0.037) and high sensitivity C-reactive protein (r = -0.208, P = 0.044). Conclusions To the best of our knowledge, this study is the first to report catestatin concentrations in obese children and adolescents and their possible relations with MS and cardiovascular risk factors in a pediatric population. Obese subjects with MS have lower serum catestatin concentrations than obese subjects without MS and controls.
C1 [Simunovic, Marko; Unic, Ivana; Skrabic, Veselin] Univ Hosp Split, Dept Pediat, Spinciceva 1, Split 21000, Croatia.
   [Supe-Domic, Daniela] Univ Hosp Split, Dept Med Lab Diagnost, Split, Croatia.
   [Karin, Zeljka] Publ Hlth Inst Split & Dalmatia Cty, Split, Croatia.
   [Degoricija, Marina] Univ Split, Dept Med Chem & Biochem, Sch Med, Split, Croatia.
   [Paradzik, Martina] Univ Hosp Split, Dept Ophthalmol, Split, Croatia.
   [Bozic, Josko] Univ Split, Dept Pathophysiol, Sch Med, Split, Croatia.
C3 University of Split; University of Split; University of Split;
   University of Split; University of Split
RP Simunovic, M (corresponding author), Univ Hosp Split, Dept Pediat, Spinciceva 1, Split 21000, Croatia.
EM markosimunovic@hotmail.com
RI škrabić, veselin/D-5564-2017; Šupe-Domić, Daniela/Y-3169-2019;
   Degoricija, Marina/D-5578-2017; Bozic, Josko/E-1866-2017
OI Bozic, Josko/0000-0003-1634-0635; Skrabic, Veselin/0000-0001-9434-5306;
   Supe Domic, Daniela/0000-0002-5584-3182; Degoricija,
   Marina/0000-0001-7023-9381
CR Angelone T, 2015, NITRIC OXIDE-BIOL CH, V50, P10, DOI 10.1016/j.niox.2015.07.004
   Angelone T, 2012, AM J PHYSIOL-HEART C, V302, pH431, DOI 10.1152/ajpheart.00491.2011
   [Anonymous], 2009, ANTHROPLUS PERS COMP
   Bandyopadhyay GK, 2017, FRONT ENDOCRINOL, V8, DOI 10.3389/fendo.2017.00020
   Bandyopadhyay GK, 2012, J BIOL CHEM, V287, P23141, DOI 10.1074/jbc.M111.335877
   Benyamin B, 2017, HUM MOL GENET, V26, P233, DOI 10.1093/hmg/ddw380
   Borovac JA, 2019, SLEEP BREATH, V23, P473, DOI 10.1007/s11325-018-1703-x
   Chiarelli F, 2008, EUR J ENDOCRINOL, V159, pS67, DOI 10.1530/EJE-08-0245
   de Onis M, 2007, B WORLD HEALTH ORGAN, V85, P660, DOI 10.2471/BLT.07.043497
   Du CQ, 2018, PEDIATR DIABETES, V19, P1058, DOI 10.1111/pedi.12685
   Durakoglugil ME, 2015, ANATOL J CARDIOL, V15, P577, DOI 10.5152/akd.2014.5536
   Falkner B, 1996, PEDIATRICS, V98, P649
   Franks PW, 2010, NEW ENGL J MED, V362, P485, DOI 10.1056/NEJMoa0904130
   Friend A, 2013, METAB SYNDR RELAT D, V11, P71, DOI 10.1089/met.2012.0122
   Gayen JR, 2010, CIRC-CARDIOVASC GENE, V3, P414, DOI 10.1161/CIRCGENETICS.109.924050
   Herrero CJ, 2002, J NEUROSCI, V22, P377, DOI 10.1523/JNEUROSCI.22-02-00377.2002
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Jurea V, 2011, CROATIAN ANTHROPOMET
   Kamal NN, 2012, DIABETOL METAB SYNDR, V4, DOI 10.1186/1758-5996-4-27
   Kennedy BP, 1998, PEPTIDES, V19, P1241, DOI 10.1016/S0196-9781(98)00086-2
   Kim J, 2010, CHEST, V138, P91, DOI 10.1378/chest.09-2832
   Kiranmayi M, 2016, HYPERTENSION, V68, P334, DOI 10.1161/HYPERTENSIONAHA.116.06568
   Magge SN, 2017, PEDIATRICS, V140, DOI 10.1542/peds.2017-1603
   Mahata SK, 2000, MOL ENDOCRINOL, V14, P1525, DOI 10.1210/me.14.10.1525
   Mahata SK, 2003, J BIOL CHEM, V278, P32058, DOI 10.1074/jbc.M305545200
   Mahata SK, 1997, J CLIN INVEST, V100, P1623, DOI 10.1172/JCI119686
   Mahata SK, 2018, CURR MED CHEM, V25, P1352, DOI 10.2174/0929867324666170425100416
   Mahata SK, 2010, REGUL PEPTIDES, V162, P33, DOI 10.1016/j.regpep.2010.01.006
   MARSHALL WA, 1969, ARCH DIS CHILD, V44, P291, DOI 10.1136/adc.44.235.291
   MARSHALL WA, 1970, ARCH DIS CHILD, V45, P13, DOI 10.1136/adc.45.239.13
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mele M, 2014, NEUROSCIENCE, V269, P331, DOI 10.1016/j.neuroscience.2014.03.065
   Meng L, 2011, J CARDIOVASC MED, V12, P643, DOI 10.2459/JCM.0b013e328346c142
   Muntjewerff EM, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.02199
   Natl High Blood Pressure Educ Prog, 2004, PEDIATRICS, V114, P555
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   O'Connor DT, 2008, CIRCULATION, V118, P247, DOI 10.1161/CIRCULATIONAHA.107.709105
   O'Connor DT, 2002, J HYPERTENS, V20, P1335, DOI 10.1097/00004872-200207000-00020
   Ogden CL, 2018, JAMA-J AM MED ASSOC, V319, P2410, DOI 10.1001/jama.2018.5158
   Pasqua T, 2017, CURR MED CHEM, V24, P3356, DOI 10.2174/0929867324666170616104759
   Rabbi MF, 2014, BIOCHEM PHARMACOL, V89, P386, DOI 10.1016/j.bcp.2014.03.003
   Rank M, 2013, J PEDIATR-US, V163, P137, DOI 10.1016/j.jpeds.2013.01.020
   Ray I, 2016, FRONT ENDOCRINOL, V7, DOI 10.3389/fendo.2016.00157
   Rieg JAD, 2016, LAB INVEST, V96, P98, DOI 10.1038/labinvest.2015.129
   Sahu BS, 2012, J BIOL CHEM, V287, P43840, DOI 10.1074/jbc.M112.407916
   Schillaci G, 2011, J CARDIOVASC MED, V12, P609, DOI 10.2459/JCM.0b013e328348d925
   Schwartz B, 2008, DIABETES CARE, V31, P783, DOI 10.2337/dc07-1376
   Simunovic M, 2016, INT J ENDOCRINOL, V2016, DOI 10.1155/2016/1823561
   van der Aa MP, 2017, J PEDIATR ENDOCR MET, V30, P123, DOI 10.1515/jpem-2016-0242
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Weiss R, 2004, NEW ENGL J MED, V350, P2362, DOI 10.1056/NEJMoa031049
   Weiss R, 2013, ANN NY ACAD SCI, V1281, P123, DOI 10.1111/nyas.12030
   Wen G, 2004, AM J HUM GENET, V74, P197, DOI 10.1086/381399
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Ying W, 2018, DIABETES, V67, P841, DOI 10.2337/db17-0788
   Zimmet P, 2007, PEDIATR DIABETES, V8, P299, DOI 10.1111/j.1399-5448.2007.00271.x
NR 56
TC 26
Z9 26
U1 1
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1399-543X
EI 1399-5448
J9 PEDIATR DIABETES
JI Pediatr. Diabetes
PD AUG
PY 2019
VL 20
IS 5
BP 549
EP 555
DI 10.1111/pedi.12825
PG 7
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA II7WO
UT WOS:000475402500007
PM 30714297
OA gold
DA 2025-06-11
ER

PT J
AU Silva, JCP
   Jones, JG
AF Silva, Joao C. P.
   Jones, John G.
TI Improving Metabolic Control Through Functional Foods
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Insulin sensitivity; type 2 diabetes; non-alcoholic fatty liver disease;
   inflammation; short-chain fatty acids; mitochondrial uncoupling
ID POLYUNSATURATED FATTY-ACIDS; OAT BETA-GLUCAN; INSULIN SENSITIVITY;
   OXIDATIVE STRESS; KETOGENIC DIET; ADIPOSE-TISSUE; KETONE-BODIES;
   RESVERATROL SUPPLEMENTATION; LIPID-PEROXIDATION; GLUCOSE-TOLERANCE
AB Background: Functional foods are designed to have physiological benefits and reduce the risk of chronic disease beyond basic nutritional functions. Conditions related to overnutrition such as Metabolic Syndrome and Type 2 diabetes are increasingly serious concerns in Western societies. Several nutrient classes are considered to protect against these conditions and this review focuses on the latest clinical and preclinical evidence supporting their efficacy and the molecular mechanisms by which they act.
   Methods: The review searched the literature for information and data on the following functional food components and their protective effects against Metabolic Syndrome and Type 2 Diabetes: Dietary fiber; Medium-chain triglycerides and Ketone esters; omega 3 Polyunsaturated fatty acids and Antioxidants.
   Results: Data from a hundred and four studies were reviewed and summarized. They indicate that dietary fiber results in the production of beneficial short chain fatty acids via intestinal microbiota, as well as increasing intestinal secretion of incretins and satiety peptides. Medium chain triglycerides and ketone esters promote thermogenesis, inhibit lipolysis and reduce inflammation. They also decrease endogenous synthesis of triglycerides and fatty acids. omega 3-PUFA's act to soften inflammation through an increase in adiponectin secretion. Antioxidants are involved in the protection of insulin sensitivity by PTP1B suppression and SIRT1 activation.
   Conclusion: Functional foods have actions that complement and/or potentiate other lifestyle interventions for reversing Metabolic Syndrome and Type 2 Diabetes. Functional foods contribute to reduced food intake by promoting satiety, less weight gain via metabolic uncoupling and improved insulin sensitivity via several distinct mechanisms.
C1 [Silva, Joao C. P.; Jones, John G.] UC Biotech, Ctr Neurosci & Cell Biol, Biocant Pk, Cantanhede, Portugal.
   [Jones, John G.] APDP Portuguese Diabet Assoc, Lisbon, Portugal.
C3 Universidade de Coimbra
RP Jones, JG (corresponding author), UC Biotech, Ctr Neurosci & Cell Biol, Biocant Pk, Cantanhede, Portugal.
EM john.griffith.jones@gmail.com
RI Jones, John/A-8684-2010
OI Jones, John/0000-0002-3745-3885
FU Portuguese Foundation for Science and Technology [EXCL/DTP/0069/2012,
   PEst-C/SAU/LA0001/2011, CENTRO-07-CT62-FEDER-002012]; FEDER - European
   Regional Development Fund through the COMPETE Programme
FX Financial support from the Portuguese Foundation for Science and
   Technology (research grant EXCL/DTP/0069/2012). Structural funding for
   the Center for Neurosciences is supported in part by FEDER - European
   Regional Development Fund through the COMPETE Programme and the
   Portuguese Foundation for Science and Technology through grants
   PEst-C/SAU/LA0001/2011 and CENTRO-07-CT62-FEDER-002012.
CR Adam CL, 2015, PLOS ONE, V10, P1, DOI DOI 10.1371/J0URNAL.P0NE.0115438
   Adam CL, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0140392
   Akinkuolie AO, 2011, CLIN NUTR, V30, P702, DOI 10.1016/j.clnu.2011.08.013
   Ärnlöv J, 2009, DIABETOLOGIA, V52, P97, DOI 10.1007/s00125-008-1189-3
   Badman MK, 2009, AM J PHYSIOL-ENDOC M, V297, pE1197, DOI 10.1152/ajpendo.00357.2009
   Blaut M, 2015, P NUTR SOC, V74, P227, DOI 10.1017/S0029665114001700
   Bloemen JG, 2009, CLIN NUTR, V28, P657, DOI 10.1016/j.clnu.2009.05.011
   Boss A, 2010, BRIT J NUTR, V103, P1151, DOI 10.1017/S000711450999287X
   Carrière A, 2014, DIABETES, V63, P3253, DOI 10.2337/db13-1885
   Cavaliere G, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0149033
   Clark MJ, 2013, J AM COLL NUTR, V32, P200, DOI 10.1080/07315724.2013.791194
   Clarke K, 2012, REGUL TOXICOL PHARM, V63, P401, DOI 10.1016/j.yrtph.2012.04.008
   Clarke K, 2012, REGUL TOXICOL PHARM, V63, P196, DOI 10.1016/j.yrtph.2012.04.001
   Cohen E, 2008, NAT REV NEUROSCI, V9, P759, DOI 10.1038/nrn2474
   Côté CD, 2015, NAT MED, V21, P498, DOI 10.1038/nm.3821
   de Ligt M, 2015, BBA-MOL BASIS DIS, V1852, P1137, DOI 10.1016/j.bbadis.2014.11.012
   De Santi C, 2000, XENOBIOTICA, V30, P1047, DOI 10.1080/00498250010002487
   De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
   DEMIGNE C, 1995, BRIT J NUTR, V74, P209, DOI 10.1079/BJN19950124
   Donohoe DR, 2011, CELL METAB, V13, P517, DOI 10.1016/j.cmet.2011.02.018
   Flachs P, 2006, DIABETOLOGIA, V49, P394, DOI 10.1007/s00125-005-0053-y
   Francini F, 2010, LIFE SCI, V86, P965, DOI 10.1016/j.lfs.2010.05.005
   Frost G, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4611
   GIBSON GR, 1995, J NUTR, V125, P1401, DOI 10.1093/jn/125.6.1401
   González-Rodríguez A, 2015, MOL NUTR FOOD RES, V59, P1431, DOI 10.1002/mnfr.201400933
   Grabitske HA, 2008, J AM DIET ASSOC, V108, P1677, DOI 10.1016/j.jada.2008.07.010
   Graff EC, 2016, METABOLISM, V65, P102, DOI 10.1016/j.metabol.2015.10.001
   Hadri Z, 2015, PHYSIOL BEHAV, V147, P198, DOI 10.1016/j.physbeh.2015.04.039
   Han JH, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0095268
   Han JR, 2003, OBES RES, V11, P734, DOI 10.1038/oby.2003.103
   Hoeks J, 2012, J CLIN ENDOCR METAB, V97, P208, DOI 10.1210/jc.2011-1884
   Hokayem M, 2013, DIABETES CARE, V36, P1454, DOI 10.2337/dc12-1652
   Howarth NC, 2003, J NUTR, V133, P3141, DOI 10.1093/jn/133.10.3141
   Jans A, 2012, AM J CLIN NUTR, V95, P825, DOI 10.3945/ajcn.111.028787
   Johnston CS, 2006, AM J CLIN NUTR, V83, P1055, DOI 10.1093/ajcn/83.5.1055
   Jornayvaz FR, 2010, AM J PHYSIOL-ENDOC M, V299, pE808, DOI 10.1152/ajpendo.00361.2010
   Juvonen KR, 2009, J NUTR, V139, P461, DOI 10.3945/jn.108.099945
   Kinzig KP, 2010, ENDOCRINOLOGY, V151, P3105, DOI 10.1210/en.2010-0175
   Klosterbuer AS, 2012, J AGR FOOD CHEM, V60, P11928, DOI 10.1021/jf303083r
   Kopprasch S, 2016, CLIN ENDOCRINOL, V84, P48, DOI 10.1111/cen.12811
   Korczak R, 2014, APPETITE, V80, P257, DOI 10.1016/j.appet.2014.05.025
   Lafond DW, 2015, NUTRIENTS, V7, P1245, DOI 10.3390/nu7021245
   Leibiger IB, 2006, NAT MED, V12, P34, DOI 10.1038/nm0106-34
   Leng R A, 1970, Adv Vet Sci Comp Med, V14, P209
   Li HT, 2012, DIABETES, V61, P797, DOI 10.2337/db11-0846
   Li L, 2007, BRAIN RES REV, V56, P384, DOI 10.1016/j.brainresrev.2007.09.001
   LIN YG, 1995, BRIT J NUTR, V74, P197, DOI 10.1079/BJN19950123
   Liu K, 2014, AM J CLIN NUTR, V99, P1510, DOI 10.3945/ajcn.113.082024
   MacIntosh CG, 2003, J NUTR, V133, P2577, DOI 10.1093/jn/133.8.2577
   Mason SA, 2016, FREE RADICAL BIO MED, V93, P227, DOI 10.1016/j.freeradbiomed.2016.01.006
   MAY T, 1994, SCAND J GASTROENTERO, V29, P916, DOI 10.3109/00365529409094863
   Montgomery MK, 2013, J LIPID RES, V54, P3322, DOI 10.1194/jlr.M040451
   Montonen J, 2004, DIABETES CARE, V27, P362, DOI 10.2337/diacare.27.2.362
   Moreno JA, 2013, NUTR METAB CARDIOVAS, V23, P536, DOI 10.1016/j.numecd.2011.10.008
   Nagao K, 2010, PHARMACOL RES, V61, P208, DOI 10.1016/j.phrs.2009.11.007
   Oh DY, 2010, CELL, V142, P687, DOI 10.1016/j.cell.2010.07.041
   Ortuño J, 2010, FOOD CHEM, V120, P1123, DOI 10.1016/j.foodchem.2009.11.032
   Park S, 2011, BRAIN RES, V1401, P95, DOI 10.1016/j.brainres.2011.05.040
   PATEL TB, 1983, ARCH BIOCHEM BIOPHYS, V220, P405, DOI 10.1016/0003-9861(83)90430-7
   Poulsen MM, 2013, DIABETES, V62, P1186, DOI 10.2337/db12-0975
   Ramel A, 2008, DIABETOLOGIA, V51, P1261, DOI 10.1007/s00125-008-1035-7
   Vinolo MAR, 2012, AM J PHYSIOL-ENDOC M, V303, pE272, DOI 10.1152/ajpendo.00053.2012
   Razny U, 2015, BBA CLIN, V4, P7, DOI 10.1016/j.bbacli.2015.05.001
   Rebello CJ, 2016, NUTR REV, V74, P131, DOI 10.1093/nutrit/nuv063
   Ristow M, 2014, NAT MED, V20, P709, DOI 10.1038/nm.3624
   Ristow M, 2009, P NATL ACAD SCI USA, V106, P8665, DOI 10.1073/pnas.0903485106
   Rodgers JT, 2005, NATURE, V434, P113, DOI 10.1038/nature03354
   Sandberg JC, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0151985
   SATO K, 1995, FASEB J, V9, P651, DOI 10.1096/fasebj.9.8.7768357
   Seljeset S, 2012, J RECEPT SIG TRANSD, V32, P196, DOI 10.3109/10799893.2012.692118
   Sena CM, 2008, NUTR RES, V28, P113, DOI 10.1016/j.nutres.2007.12.005
   Shen RL, 2012, J AGR FOOD CHEM, V60, P11301, DOI 10.1021/jf302824h
   Slavin J, 2013, NUTRIENTS, V5, P1417, DOI 10.3390/nu5041417
   Sohet FM, 2009, BRIT J NUTR, V102, P462, DOI 10.1017/S0007114508191243
   Somova L, 1999, METHOD FIND EXP CLIN, V21, P275, DOI 10.1358/mf.1999.21.4.538178
   Srivastava S, 2012, FASEB J, V26, P2351, DOI 10.1096/fj.11-200410
   Taggart AKP, 2005, J BIOL CHEM, V280, P26649, DOI 10.1074/jbc.C500213200
   Takeuchi H, 2006, LIPIDS, V41, P207, DOI 10.1007/s11745-006-5089-3
   Takikawa M, 2010, J NUTR, V140, P527, DOI 10.3945/jn.109.118216
   Thies F, 2003, LANCET, V361, P477, DOI 10.1016/S0140-6736(03)12468-3
   Tishinsky JM, 2011, OBESITY, V19, P262, DOI 10.1038/oby.2010.186
   Todoric J, 2006, DIABETOLOGIA, V49, P2109, DOI 10.1007/s00125-006-0300-x
   Tomé-Carneiro J, 2013, CURR PHARM DESIGN, V19, P6064, DOI 10.2174/13816128113199990407
   Topping D, 2007, J CEREAL SCI, V46, P220, DOI 10.1016/j.jcs.2007.06.004
   Turner N, 2009, DIABETES, V58, P2547, DOI 10.2337/db09-0784
   Valagussa F, 1999, LANCET, V354, P447, DOI 10.1016/S0140-6736(99)07072-5
   van Dijk G, 2015, FRONT NEUROSCI-SWITZ, V9, DOI 10.3389/fnins.2015.00173
   Veech RL, 2004, PROSTAG LEUKOTR ESS, V70, P309, DOI 10.1016/j.plefa.2003.09.007
   Walle T, 2011, ANN NY ACAD SCI, V1215, P9, DOI 10.1111/j.1749-6632.2010.05842.x
   Wanders AJ, 2014, PHYSIOL BEHAV, V128, P212, DOI 10.1016/j.physbeh.2014.02.007
   Wanders AJ, 2013, BRIT J NUTR, V109, P1330, DOI 10.1017/S0007114512003145
   Whitmer RA, 2007, CURR NEUROL NEUROSCI, V7, P373, DOI 10.1007/s11910-007-0058-7
   Winzell MS, 2006, AM J PHYSIOL-ENDOC M, V290, pE347, DOI 10.1152/ajpendo.00163.2005
   WOLEVER TMS, 1995, AM J CLIN NUTR, V61, P1241, DOI 10.1093/ajcn/61.6.1241
   Won YJ, 2013, J NEUROSCI, V33, P19314, DOI 10.1523/JNEUROSCI.3102-13.2013
   Wong JMW, 2006, J CLIN GASTROENTEROL, V40, P235, DOI 10.1097/00004836-200603000-00015
   Xiao C, 2006, DIABETOLOGIA, V49, P1371, DOI 10.1007/s00125-006-0211-x
   Xu F, 2009, DIABETES, V58, pA3, DOI 10.2337/db08-1637
   Xu WL, 2009, DIABETOLOGIA, V52, P1031, DOI 10.1007/s00125-009-1323-x
   Yoshino J, 2012, CELL METAB, V16, P658, DOI 10.1016/j.cmet.2012.09.015
   Youm YH, 2015, NAT MED, V21, P263, DOI 10.1038/nm.3804
   Yun J, 2014, CELL METAB, V19, P757, DOI 10.1016/j.cmet.2014.01.011
   Zhang HH, 2015, J PHYSIOL BIOCHEM, V71, P121, DOI 10.1007/s13105-015-0392-1
   Zhang Y, 2016, J SCI FOOD AGR, V96, P484, DOI 10.1002/jsfa.7114
NR 104
TC 8
Z9 8
U1 3
U2 40
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2019
VL 26
IS 19
BP 3424
EP 3438
DI 10.2174/0929867324666170523130123
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA IX6HC
UT WOS:000485782800004
PM 28545368
DA 2025-06-11
ER

PT J
AU Lee, JH
   Seo, DH
   Nam, MJ
   Lee, GH
   Yang, DH
   Lee, MJ
   Choi, UR
   Hong, S
AF Lee, Jung Hwan
   Seo, Da Hea
   Nam, Min Jung
   Lee, Geon Hui
   Yang, Dong Hee
   Lee, Min Joo
   Choi, Ung-Rim
   Hong, Seongbin
TI The Prevalence of Obesity and Metabolic Syndrome in the Korean Military
   Compared with the General Population
SO JOURNAL OF KOREAN MEDICAL SCIENCE
LA English
DT Article
DE Metabolic Syndrome; Obesity; Military; Cross-sectional Survey
ID BODY-MASS INDEX; NUTRITION EXAMINATION SURVEY; CIGARETTE-SMOKING;
   RISK-FACTORS; CARDIOVASCULAR RISK; NATIONAL-HEALTH; BRITISH ARMY;
   HYPERTENSION; US; ASSOCIATION
AB Background: Obesity and related metabolic disorders are growing health challenges worldwide and individuals at military service are not exceptions. The purpose of this study was to examine the prevalence of obesity and metabolic syndrome (MS) in the Korean military and to compare with the general population.
   Methods: This was a cross-sectional study of 4,803 young military participants who underwent a corporal health-screening program between October 2013 and October 2014. The National Cholesterol Education Program Adult Treatment Panel III criteria was used to identify MS. We also sampled 1,108 men aged 19-29 years from the Korea National Health and Nutritional Examination Survey from 2010 to 2013 to compare with their military counterparts.
   Results: The mean age of military participants was 20.8 +/- 1.1 years, and 20.6% (n = 988) were obese. The prevalence of MS was 0.8% in military participants, while 7.9% in general population. The risk factors of MS were less prominent among military participants relative to civilians, with the exception of high blood pressure, of which prevalence was higher among military participants (21.5% vs. 18.2%, respectively). In multiple logistic analysis, high physical activity conferred lower odds of MS and obesity in military participants (odds ratios, 0.19 and 0.81, respectively). Age older than 25 years increased risk of most components of MS among civilians.
   Conclusion: The prevalence of obesity and MS is lower in military participants compared with civilians of similar age. Monitoring of high blood pressure and proper stress management are warranted in those at military service.
C1 [Lee, Jung Hwan; Nam, Min Jung; Lee, Geon Hui; Yang, Dong Hee; Lee, Min Joo; Choi, Ung-Rim] Republ Korea Armed Forces, Med Battal, Div 5, Yeoncheon, South Korea.
   [Lee, Jung Hwan; Seo, Da Hea; Hong, Seongbin] Inha Univ, Sch Med, Dept Internal Med, Inha Univ Hosp,Div Endocrinol & Metab, 27 Inhang Ro, Incheon 22332, South Korea.
C3 Inha University; Inha University Hospital
RP Hong, S (corresponding author), Inha Univ, Sch Med, Dept Internal Med, Inha Univ Hosp,Div Endocrinol & Metab, 27 Inhang Ro, Incheon 22332, South Korea.
EM sbhongmd@inha.ac.kr
RI Rhee, Yumie/L-8020-2019; Lee, Kee-Joon/AAA-4090-2022
OI Hong, Seongbin/0000-0002-8189-395X; Seo, Da Hea/0000-0003-2767-0293
FU Korean Military Medical Research Program [2014-KMMRP-015]; Inha
   University Research Grant
FX This research was supported by Korean Military Medical Research Program
   (Grant number: 2014-KMMRP-015) and Inha University Research Grant.
CR Al-Qahtani DA, 2005, SAUDI MED J, V26, P1360
   ALBANES D, 1987, AM J PUBLIC HEALTH, V77, P439, DOI 10.2105/AJPH.77.4.439
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Bauduceau B, 2005, DIABETES METAB, V31, P353, DOI 10.1016/S1262-3636(07)70204-5
   Blacker SD, 2011, MIL MED, V176, P1376, DOI 10.7205/MILMED-D-11-00166
   Braga RT, 2014, AM J MENS HEALTH, V8, P310, DOI 10.1177/1557988313510928
   Brown CD, 2000, OBES RES, V8, P605, DOI 10.1038/oby.2000.79
   Ceppa F, 2008, MIL MED, V173, P960, DOI 10.7205/MILMED.173.10.960
   Chen CC, 2008, METABOLISM, V57, P544, DOI 10.1016/j.metabol.2007.11.018
   Chiolero A, 2008, AM J CLIN NUTR, V87, P801, DOI 10.1093/ajcn/87.4.801
   da Costa FF, 2011, ARQ BRAS CARDIOL, V97, P485, DOI 10.1590/S0066-782X2011005000113
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   FLEGAL KM, 1995, NEW ENGL J MED, V333, P1165, DOI 10.1056/NEJM199511023331801
   Granado NS, 2009, HYPERTENSION, V54, P966, DOI 10.1161/HYPERTENSIONAHA.109.132555
   Grundy SM, 2006, CURR OPIN CARDIOL, V21, P1, DOI 10.1097/01.hco.0000200416.65370.a0
   Herzog CM, 2015, MIL MED, V180, P83, DOI 10.7205/MILMED-D-14-00039
   Ishizaka N, 2005, ATHEROSCLEROSIS, V181, P381, DOI 10.1016/j.atherosclerosis.2005.01.026
   John U, 2006, QJM-INT J MED, V99, P407, DOI 10.1093/qjmed/hcl047
   Kalff KG, 1999, AVIAT SPACE ENVIR MD, V70, P1223
   Khazale NS, 2007, AVIAT SPACE ENVIR MD, V78, P968, DOI 10.3357/ASEM.2097.2007
   Kim J, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-624
   Lim S, 2011, DIABETES CARE, V34, P1323, DOI 10.2337/dc10-2109
   McGraw LK, 2008, J CARDIOVASC NURS, V23, P338, DOI 10.1097/01.JCN.0000317437.75081.e7
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Papathanasiou George, 2015, Open Cardiovasc Med J, V9, P5, DOI 10.2174/1874192401509010005
   Park J, 2008, ASIA PAC J CLIN NUTR, V17, P471
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Payab M, 2017, AM J MENS HEALTH, V11, P404, DOI 10.1177/1557988316683120
   Shihab HM, 2012, CIRCULATION, V126, P2983, DOI 10.1161/CIRCULATIONAHA.112.117333
   Sneve M, 2008, SCAND J PUBLIC HEALT, V36, P397, DOI 10.1177/1403494807088453
   Stensvold D, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-109
   Stewart IJ, 2017, BURNS, V43, P290, DOI 10.1016/j.burns.2016.10.005
   Suh S, 2014, ENDOCRINOL METAB, V29, P522, DOI 10.3803/EnM.2014.29.4.522
   Suh S, 2014, J ATHEROSCLER THROMB, V21, pS31
   Virdis A, 2010, CURR PHARM DESIGN, V16, P2518, DOI 10.2174/138161210792062920
   Whitlock G, 2009, LANCET, V373, P1083, DOI 10.1016/S0140-6736(09)60318-4
   Williams AG, 2005, J STRENGTH COND RES, V19, P254
   Williams AG, 1999, ERGONOMICS, V42, P1114, DOI 10.1080/001401399185171
   Zimmet P, 2001, NATURE, V414, P782, DOI 10.1038/414782a
NR 39
TC 12
Z9 13
U1 0
U2 4
PU KOREAN ACAD MEDICAL SCIENCES
PI SEOUL
PA 302 75 DONG DU ICHON, DONG YONGSAN KU, SEOUL 140 031, SOUTH KOREA
SN 1011-8934
EI 1598-6357
J9 J KOREAN MED SCI
JI J. Korean Med. Sci.
PD JUN 18
PY 2018
VL 33
IS 25
AR e172
DI 10.3346/jkms.2018.33.e172
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA GJ8JU
UT WOS:000435636500002
PM 29915523
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yadav, D
   Lee, MY
   Kim, JY
   Ryu, H
   Huh, JH
   Bae, KS
   Ahn, SV
   Chung, CH
   Park, JT
   Koh, SB
AF Yadav, Dhananjay
   Lee, Mi Young
   Kim, Jang Young
   Ryu, Hoon
   Huh, Ji Hye
   Bae, Keum Seok
   Ahn, Song Vogue
   Chung, Choon Hee
   Park, Jong Taek
   Koh, Sang Baek
TI Combined Effect of Initial and Longitudinal Increases in
   γ-Glutamyltransferase on Incident Metabolic Syndrome: ARIRANG Study
SO YONSEI MEDICAL JOURNAL
LA English
DT Article
DE gamma-glutamyltransferase; cohort; metabolic syndrome
ID BODY-MASS INDEX; C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; OXIDATIVE
   STRESS; WAIST CIRCUMFERENCE; INSULIN-RESISTANCE; RISK; OBESITY;
   ASSOCIATION; PREDICTOR
AB Purpose: Although gamma-glutamyltransferase (GGT) is well known to be associated with metabolic syndrome (MS), prospective data on baseline and longitudinal changes in GGT levels and incident cases of MS are limited. We aimed to examine prospective associations between changes in GGT levels over time, as well as at baseline, and incident MS in Korean adults.
   Materials and Methods: A total of 2579 Korean adults free of MS were followed up for 2.6 years. Data were collected from 20052008 (baseline) and from 2008-2011 (follow-up). Serum GGT levels were determined by enzymatic methods.
   Results: During follow-up, 558 participants (21.6%) developed MS. A gradual increase in the incidence of MS was observed across GGT quartiles. After adjustment for confounding factors, the odds ratio and 95% confidence interval (CI) for new onset MS, comparing the highest to the lowest quartiles of baseline GGT, was 2.07 (95% CI: 1.52-2.80). The odds ratio for the highest GGT changes (>4 IU/L increase) in comparison to the lowest GGT changes (<-5 IU/L decrease) was 1.75 (95% CI: 1.32-2.33). Among participants with baseline GGT concentrations <the median, the odds ratio for incident MS, comparing participants with the highest GGT changes with the lowest GGT changes, was 1.52 (95% CI: 1.01-2.31). Among participants with baseline GGT concentration >= the median, the corresponding odds ratio was 2.75 (95% CI: 1.84-4.10).
   Conclusion: High initial GGT concentration and increases in GGT concentration over time should be considered independent predictors of and to have a combined effect on incident MS.
C1 [Yadav, Dhananjay; Ahn, Song Vogue; Koh, Sang Baek] Yonsei Univ, Wonju Coll Med, Dept Prevent Med, Wonju, South Korea.
   [Lee, Mi Young; Kim, Jang Young; Huh, Ji Hye; Chung, Choon Hee] Yonsei Univ, Wonju Coll Med, Dept Internal Med, Wonju, South Korea.
   [Ryu, Hoon; Bae, Keum Seok] Yonsei Univ, Wonju Coll Med, Dept Surg, Wonju, South Korea.
   [Park, Jong Taek] Yonsei Univ, Wonju Coll Med, Dept Anesthesiol & Pain Med, 20 Ilsan Ro, Wonju 26426, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University; Yonsei
   University
RP Park, JT (corresponding author), Yonsei Univ, Wonju Coll Med, Dept Anesthesiol & Pain Med, 20 Ilsan Ro, Wonju 26426, South Korea.; Kim, JY (corresponding author), Yonsei Univ, Wonju Coll Med, Div Cardiol, Dept Internal Med, 20 Ilsan Ro, Wonju 26426, South Korea.
EM kimjy@yonsei.ac.kr; jtp999@yonsei.ac.kr
RI Cho, Young/J-5669-2012; Ahn, Song/AAK-2900-2021; park, jun
   yeon/GPX-5293-2022; Yadav, Dhananjay/AAZ-9435-2021; Ryu,
   Hoon/MCJ-9411-2025; Kim, Nam Hoon/HNS-5794-2023
OI Chung, Choon/0000-0003-1144-7206
FU Korea Centers for Disease Control and Prevention [2005-E71013-00,
   2006-E71002-00, 2007-E71013-00, 2008-E71004-00, 2009-E71006-00,
   2010-E71003-00]
FX This study was supported in part by a grant from the Korea Centers for
   Disease Control and Prevention (2005-E71013-00, 2006-E71002-00,
   2007-E71013-00, 2008-E71004-00, 2009-E71006-00, 2010-E71003-00).
CR Abete I, 2011, NUTR METAB CARDIOVAS, V21, pB1, DOI 10.1016/j.numecd.2011.05.001
   Bener A, 2013, J OBES, V2013, DOI 10.1155/2013/269038
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Chitturi S, 2002, HEPATOLOGY, V35, P373, DOI 10.1053/jhep.2002.30692
   Emdin M, 2005, CIRCULATION, V112, P2078, DOI 10.1161/CIRCULATIONAHA.105.571919
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Janssen I, 2004, AM J CLIN NUTR, V79, P379
   Kawamoto R, 2009, J ATHEROSCLER THROMB, V16, P355, DOI 10.5551/jat.No414
   Kerner A, 2005, ARTERIOSCL THROM VAS, V25, P193, DOI 10.1161/01.ATV.0000148324.63685.6a
   Kim JY, 2013, DIABETES CARE, V36, P1547, DOI 10.2337/dc12-0223
   Kim NH, 2012, CLIN EXP HYPERTENS, V34, P402, DOI 10.3109/10641963.2012.665539
   KUGELMAN A, 1994, AM J RESP CELL MOL, V11, P586, DOI 10.1165/ajrcmb.11.5.7946387
   Lee DH, 2004, FREE RADICAL RES, V38, P535, DOI 10.1080/10715760410001694026
   Lee DH, 2003, CLIN CHEM, V49, P1358, DOI 10.1373/49.8.1358
   Lee DH, 2003, DIABETOLOGIA, V46, P359, DOI 10.1007/s00125-003-1036-5
   Lee DS, 2007, ARTERIOSCL THROM VAS, V27, P127, DOI 10.1161/01.ATV.0000251993.20372.40
   Lee MY, 2008, DIABETIC MED, V25, P469, DOI 10.1111/j.1464-5491.2008.02415.x
   Lee SY, 2007, DIABETES RES CLIN PR, V75, P72, DOI 10.1016/j.diabres.2006.04.013
   Lim S, 2011, DIABETES CARE, V34, P1323, DOI 10.2337/dc10-2109
   Liu CF, 2012, INT J CLIN PRACT, V66, P692, DOI 10.1111/j.1742-1241.2012.02959.x
   Marchesini G, 2001, DIABETES, V50, P1844, DOI 10.2337/diabetes.50.8.1844
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Nakanishi N, 2004, DIABETES CARE, V27, P1427, DOI 10.2337/diacare.27.6.1427
   Ridker PM, 2004, CIRCULATION, V109, P2818, DOI 10.1161/01.CIR.0000132467.45278.59
   Roberts CK, 2006, METABOLISM, V55, P928, DOI 10.1016/j.metabol.2006.02.022
   Ruttmann E, 2005, CIRCULATION, V112, P2130, DOI 10.1161/CIRCULATIONAHA.105.552547
   Ryu S, 2010, METABOLISM, V59, P683, DOI 10.1016/j.metabol.2009.08.024
   Sattar N, 2008, LANCET, V371, P1927, DOI 10.1016/S0140-6736(08)60602-9
   Scott R, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-102
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Suh BS, 2012, KOREAN J FAM MED, V33, P51, DOI 10.4082/kjfm.2012.33.1.51
   WANNAMETHEE G, 1995, AM J EPIDEMIOL, V142, P699, DOI 10.1093/oxfordjournals.aje.a117699
   Wei M, 1997, OBES RES, V5, P16, DOI 10.1002/j.1550-8528.1997.tb00278.x
   Whitfield JB, 2001, CRIT REV CL LAB SCI, V38, P263, DOI 10.1080/20014091084227
NR 34
TC 8
Z9 9
U1 0
U2 1
PU YONSEI UNIV COLL MEDICINE
PI SEOUL
PA 50-1 YONSEI-RO, SEODAEMUN-GU, SEOUL 120-752, SOUTH KOREA
SN 0513-5796
EI 1976-2437
J9 YONSEI MED J
JI Yonsei Med. J.
PD JUL
PY 2017
VL 58
IS 4
BP 763
EP 769
DI 10.3349/ymj.2017.58.4.763
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FD8AL
UT WOS:000407747400012
PM 28540989
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Ruan, YP
   Wei, WL
   Yan, JH
   Sun, LX
   Lian, H
   Zhao, XY
   Liang, RJ
   Liu, XL
   Fan, ZJ
AF Ruan, Yanping
   Wei, Wanlin
   Yan, Jianhua
   Sun, Lixian
   Lian, Hui
   Zhao, Xiaoyi
   Liang, Ruijuan
   Liu Xiaole
   Fan, Zhongjie
TI Time Rate of Blood Pressure Variation Is Associated With Endothelial
   Function in Patients With Metabolic Syndrome
SO INTERNATIONAL HEART JOURNAL
LA English
DT Article
DE RHI; Ambulatory blood pressure monitoring; Target organ damage; Blood
   pressure variability
ID INTIMA-MEDIA THICKNESS; VISIT-TO-VISIT; CARDIOVASCULAR RISK; VASCULAR
   FUNCTION; SHEAR-STRESS; VARIABILITY; ATHEROSCLEROSIS; AMPLITUDE; IMPACT
AB The time rate of blood pressure (BP) variation indicates the speed of BP fluctuations. Previous studies have demonstrated that the time rate of BP variation was associated with target organ damage. However, the association between time rate of BP variation and endothelial function has not been evaluated.
   24-hour ambulatory blood pressure monitoring (ABPM) was performed in 61 patients with metabolic syndrome. Time rate of BP variation was calculated from BP recordings of ABPM. Endothelial function was assessed using reactive hyperemia-peripheral arterial tonometry index (RHI) by EndoPat2000. Multiple linear regression models were used to detect the association between time rate of BP variation and RHI.
   Among all the subjects (n = 61), the multiple linear regression models revealed that the daytime rate of systolic blood pressure (SBP) variation was independently associated with RHI (beta = -0.334, P = 0.008). A 0.1 mmHg/minute increase in the daytime rate of SBP variation correlated with a decline of 0.20 in RHI. The same effect was also found in the subjects with eGFR >= 60 mL/(minute*1.73 m(2)). A greater association was found in those who were not taking a statin, beta-blocker, ACEI/ARB, or diuretic and those without diabetes compared with those with any antihypertensive medication or with diabetes.
   Other ambulatory blood pressure parameters and central hemodynamics were not found to be associated with RHI. Our findings have shown that the daytime rate of SBP variation was associated with endothelial function in patients with metabolic syndrome, independent of other BP parameters and central hemodynamics.
C1 [Ruan, Yanping; Lian, Hui; Zhao, Xiaoyi; Liang, Ruijuan; Liu Xiaole; Fan, Zhongjie] Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Cardiol, Beijing 100021, Peoples R China.
   [Ruan, Yanping; Lian, Hui; Zhao, Xiaoyi; Liang, Ruijuan; Liu Xiaole; Fan, Zhongjie] Chinese Acad Med Sci, Beijing 100730, Peoples R China.
   [Wei, Wanlin] Beijing Mil Command, Gen Hosp, Dept Cardiol, Beijing, Peoples R China.
   [Yan, Jianhua] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Div Cardiovasc Med, Chengde, Hebei, Peoples R China.
   [Sun, Lixian] Chengde Med Coll, Affiliated Hosp, Div Cardiovasc Med, Chengde, Hebei, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Seventh Medical Center of Chinese PLA General Hospital; Shanghai Jiao
   Tong University; Chengde Medical University
RP Fan, ZJ (corresponding author), Beijing Union Med Coll Hosp, Dept Cardiol, 1 Shuai Fu Yuan, Beijing, Peoples R China.
EM Fan@pumch.cn
CR Bonetti PO, 2003, ARTERIOSCL THROM VAS, V23, P168, DOI 10.1161/01.ATV.0000051384.43104.FC
   De Keulenaer GW, 1998, CIRC RES, V82, P1094, DOI 10.1161/01.RES.82.10.1094
   Diaz KM, 2012, HYPERTENS RES, V35, P55, DOI 10.1038/hr.2011.135
   Eguchi K, 2009, AM J HYPERTENS, V22, P46, DOI 10.1038/ajh.2008.294
   Hamburg NM, 2008, CIRCULATION, V117, P2467, DOI 10.1161/CIRCULATIONAHA.107.748574
   Hata J, 2013, CIRCULATION, V128, P1325, DOI 10.1161/CIRCULATIONAHA.113.002717
   Heo KS, 2014, MOL CELLS, V37, P435, DOI [10.14348/molcells.2014.0078, 10.14348/molcells.2014.0108]
   Hermida RC, 2013, HYPERTENSION, V61, pE3, DOI 10.1161/HYPERTENSIONAHA.111.00249
   Hodgson JM, 2014, ATHEROSCLEROSIS, V233, P48, DOI 10.1016/j.atherosclerosis.2013.12.026
   Kuvin JT, 2003, AM HEART J, V146, P168, DOI 10.1016/S0002-8703(03)00094-2
   LERMAN A, 1992, CIRCULATION, V86, P12
   Malek AM, 1999, JAMA-J AM MED ASSOC, V282, P2035, DOI 10.1001/jama.282.21.2035
   Mancia G, 2003, HYPERTENSION, V42, P277, DOI 10.1161/01.HYP.0000084632.33942.5F
   Manios E, 2011, J HYPERTENS, V29, P1109, DOI 10.1097/HJH.0b013e3283454ff4
   Manios E, 2009, J HYPERTENS, V27, P2244, DOI 10.1097/HJH.0b013e328330a94f
   Mihos CG, 2014, PHARMACOL RES, V88, P12, DOI 10.1016/j.phrs.2014.02.009
   Nohria A, 2006, J APPL PHYSIOL, V101, P545, DOI 10.1152/japplphysiol.01285.2005
   Parati G, 2013, BLOOD PRESSURE, V22, P345, DOI 10.3109/08037051.2013.782944
   Rothwell PM, 2010, LANCET, V375, P938, DOI 10.1016/S0140-6736(10)60309-1
   Skalidi SJ, 2013, BLOOD PRESS MONIT, V18, P203, DOI 10.1097/MBP.0b013e3283631b28
   Stamatelopoulos KS, 2010, J HYPERTENS, V28, P51, DOI 10.1097/HJH.0b013e328331b6c8
   Suessenbacher A, 2014, J ATHEROSCLER THROMB, V21, P230, DOI 10.5551/jat.18986
   Wang C, 2013, PLOS ONE, V8, DOI [10.1371/journal.pone.0060462, 10.1371/journal.pone.0065120, 10.1371/journal.pone.0068807]
   Williams B, 2006, CIRCULATION, V113, P1213, DOI 10.1161/CIRCULATIONAHA.105.595496
   Zakopoulos NA, 2005, HYPERTENSION, V45, P505, DOI 10.1161/01.HYP.0000158306.87582.43
   Zakopoulos NA, 2006, J HYPERTENS, V24, P2071, DOI 10.1097/01.hjh.0000244957.47114.88
NR 26
TC 8
Z9 9
U1 0
U2 6
PU INT HEART JOURNAL ASSOC
PI TOKYO
PA UNIV TOKYO, GRADUATE SCHOOL MEDICINE, DEPT CARDIOVASCULAR MEDICINE,
   HONGO 7-3-1, BUNKYO-KU, TOKYO, 113-8655, JAPAN
SN 1349-2365
EI 1349-3299
J9 INT HEART J
JI Int. Heart J.
PD MAR
PY 2016
VL 57
IS 2
BP 226
EP 233
DI 10.1536/ihj.15-322
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DL3GS
UT WOS:000375522800017
PM 26973261
OA Bronze
DA 2025-06-11
ER

PT J
AU Yuan, ZP
   Liu, CG
   Tian, YP
   Zhang, XH
   Ye, HZ
   Jin, LF
   Ruan, LS
   Sun, ZH
   Zhu, YM
AF Yuan, Zheping
   Liu, Chengguo
   Tian, Yiping
   Zhang, Xuhui
   Ye, Huaizhuang
   Jin, Lifeng
   Ruan, Liansheng
   Sun, Zhanhang
   Zhu, Yimin
TI Higher Levels of Magnesium and Lower Levels of Calcium in Whole Blood
   Are Positively Correlated with the Metabolic Syndrome in a Chinese
   Population: A Case-Control Study
SO ANNALS OF NUTRITION AND METABOLISM
LA English
DT Article
DE Magnesium; Calcium; Ca to Mg ratio; Metabolic syndrome
ID INSULIN-RESISTANCE; PARATHYROID-HORMONE; DIABETES-MELLITUS;
   SERUM-CALCIUM; RISK-FACTORS; CARDIOVASCULAR-DISEASE; INTRACELLULAR
   CALCIUM; DIETARY MAGNESIUM; CELLULAR CALCIUM; OXIDATIVE STRESS
AB Magnesium (Mg) and calcium (Ca) are essential for numerous kinds of metabolisms in human body. To investigate the associations between Mg and Ca and the ratio of Ca to Mg (Ca/Mg) in whole blood with metabolic syndrome (MetS) in a Chinese population, a matched case-control study including 204 MetS patients and 204 healthy controls (aged 48-89) was carried out in 2011. MetS were diagnosed according to the criteria of Chinese Diabetes Society. Controls had no abnormal metabolic components and were matched with cases by age, gender and region. Blood samples were collected in the morning after an overnight fast. Whole blood Mg and Ca were determined by flame atomic absorption spectrometry. Subjects who were male constituted 44.1% of the part of this study. The average age was 64.0 +/- 7.18, and the average body mass index was 24.3 +/- 3.75. The MetS group showed significantly higher Mg and lower Ca and Ca/Mg as compared with the control group. Comparing with the bottom tertile (T1) of Mg, increased ORs for MetS were found in median tertile (T2) and top tertile (T3) of Mg. For Ca, T2 and T3 were negatively associated with MetS. Inverse relationship was also found between Ca/Mg ratio and MetS. Our findings suggested that increased Mg and decreased Ca and Ca/Mg in whole blood were correlated with MetS in Chinese adults. (C) 2016 S. Karger AG, Basel
C1 [Yuan, Zheping; Zhu, Yimin] Zhejiang Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, 866 Yu Hang Tang Rd, Hangzhou 310058, Zhejiang, Peoples R China.
   [Ye, Huaizhuang; Jin, Lifeng] Zhejiang Univ, Sch Publ Hlth, Ctr Expt Teaching, Hangzhou, Zhejiang, Peoples R China.
   [Tian, Yiping] Zhejiang Univ, Sch Med, Dept Pathol, Hangzhou, Zhejiang, Peoples R China.
   [Zhang, Xuhui] Hangzhou Ctr Dis Control & Prevent, Dept Nutr & Food Safety, Hangzhou, Zhejiang, Peoples R China.
   [Liu, Chengguo; Ruan, Liansheng; Sun, Zhanhang] Zhejiang Putuo Hosp, Dept Endocrinol & Inst Cardiovasc Dis, Zhoushan, Peoples R China.
C3 Zhejiang University; Zhejiang University; Zhejiang University
RP Zhu, YM (corresponding author), Zhejiang Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, 866 Yu Hang Tang Rd, Hangzhou 310058, Zhejiang, Peoples R China.
EM zhuym@zju.edu.cn
RI Liu, Chengguo/IUM-6475-2023; Zhu, Yimin/D-6387-2017; 张, 旭晖/HLG-4912-2023
FU National Key Technology R&D Program of China [2012BAI02B03]; National
   Natural Science Foundation of China [81172755]; Program for Zhejiang
   Leading Team of Science and Technology Innovation [2010R50050]
FX This study has been supported by National Key Technology R&D Program of
   China (2012BAI02B03), National Natural Science Foundation of China
   (81172755). Zhejiang Provincial Program for the Cultivation of
   High-Level Innovative Health Talents, Fundamental Research Funds for the
   Central Universities and Program for Zhejiang Leading Team of Science
   and Technology Innovation (2010R50050).
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Ahlström T, 2009, CLIN ENDOCRINOL, V71, P673, DOI 10.1111/j.1365-2265.2009.03558.x
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   [Anonymous], 2004, CHIN J DIAB, V12, P156, DOI 10.3321/j.issn:1006-6187.2004.03.002
   Baldi S, 1996, METABOLISM, V45, P1402, DOI 10.1016/S0026-0495(96)90122-5
   Barbagallo M, 2007, ARCH BIOCHEM BIOPHYS, V458, P40, DOI 10.1016/j.abb.2006.05.007
   Barbagallo Mario, 2003, Molecular Aspects of Medicine, V24, P39, DOI 10.1016/S0098-2997(02)00090-0
   BEGUM N, 1991, CELL CALCIUM, V12, P423, DOI 10.1016/0143-4160(91)90068-P
   Bo S, 2008, CURR OPIN LIPIDOL, V19, P50, DOI 10.1097/MOL.0b013e3282f33ccc
   Brown EM, 2001, PHYSIOL REV, V81, P239, DOI 10.1152/physrev.2001.81.1.239
   Bussière FI, 2002, EUR J NUTR, V41, P197, DOI 10.1007/s00394-002-0376-0
   Cameron AJ, 2004, ENDOCRIN METAB CLIN, V33, P351, DOI 10.1016/j.ecl.2004.03.005
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Cho GJ, 2009, MENOPAUSE, V16, P992, DOI 10.1097/gme.0b013e31819e23cb
   Choi WS, 2014, BIOL TRACE ELEM RES, V158, P323, DOI 10.1007/s12011-014-9946-2
   Chung JH, 2012, BIOL TRACE ELEM RES, V150, P26, DOI 10.1007/s12011-012-9474-x
   Currie LA, 1999, ANAL CHIM ACTA, V391, P105, DOI 10.1016/S0003-2670(99)00104-X
   DeFronzo RA, 1997, NETH J MED, V50, P191, DOI 10.1016/S0300-2977(97)00012-0
   Dimai HP, 2000, CLIN BIOCHEM, V33, P329, DOI 10.1016/S0009-9120(00)00074-6
   DRAZNIN B, 1988, J CLIN INVEST, V82, P1848, DOI 10.1172/JCI113801
   Farhangi MA, 2011, BIOCHEM MEDICA, V21, P312
   Ford ES, 2007, OBESITY, V15, P1139, DOI 10.1038/oby.2007.628
   Ford ES, 2010, J DIABETES, V2, P180, DOI 10.1111/j.1753-0407.2010.00078.x
   Ghasemi A, 2010, BIOL TRACE ELEM RES, V136, P18, DOI 10.1007/s12011-009-8522-7
   Guerrero-Romero F, 2002, ACTA DIABETOL, V39, P209, DOI 10.1007/s005920200036
   Guerrero-Romero F, 2006, DIABETES-METAB RES, V22, P471, DOI 10.1002/dmrr.644
   Hollman G, 2008, EUR J CARDIOVASC NUR, V7, P21, DOI 10.1016/j.ejcnurse.2007.05.003
   Huang JH, 2012, NUTR J, V11, DOI 10.1186/1475-2891-11-41
   Huang LN, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027703
   Huerta MG, 2005, DIABETES CARE, V28, P1175, DOI 10.2337/diacare.28.5.1175
   ISERI LT, 1984, AM HEART J, V108, P188, DOI 10.1016/0002-8703(84)90572-6
   Jorde R, 2010, EUR J CLIN NUTR, V64, P1457, DOI 10.1038/ejcn.2010.176
   Jorde R, 2010, J INTERN MED, V267, P462, DOI 10.1111/j.1365-2796.2009.02181.x
   KESTELOOT H, 1990, J HUM HYPERTENS, V4, P527
   Klibanski A, 2001, JAMA-J AM MED ASSOC, V285, P785
   La SA, 2016, BIOL TRACE ELEM RES, V170, P33, DOI 10.1007/s12011-015-0446-9
   LEVY J, 1994, AM J MED, V96, P260, DOI 10.1016/0002-9343(94)90152-X
   Lima Maria de Lourdes, 2005, Arq Bras Endocrinol Metab, V49, P959, DOI 10.1590/S0004-27302005000600016
   LIND L, 1988, BMJ-BRIT MED J, V297, P960, DOI 10.1136/bmj.297.6654.960
   Liu S, 2005, DIABETES CARE, V28, P2926, DOI 10.2337/diacare.28.12.2926
   Liu WM, 2004, SPECTROSC SPECT ANAL, V24, P360
   MAHFOUZ MM, 1989, LIPIDS, V24, P727, DOI 10.1007/BF02535212
   McCarron D A, 1995, Keio J Med, V44, P105
   Mears D, 2004, J MEMBRANE BIOL, V200, P57, DOI 10.1007/s00232-004-0692-9
   Mirmiran P, 2012, PUBLIC HEALTH NUTR, V15, P693, DOI 10.1017/S1368980011002941
   Moore-Schiltz L, 2015, BRIT J NUTR, V114, P924, DOI 10.1017/S0007114515002482
   NORMAN DA, 1981, J CLIN INVEST, V67, P1599, DOI 10.1172/JCI110194
   Paolisso G, 1997, AM J HYPERTENS, V10, P346, DOI 10.1016/S0895-7061(96)00342-1
   PAOLISSO G, 1990, DIABETOLOGIA, V33, P511, DOI 10.1007/BF00404136
   Park SH, 2012, BIOL TRACE ELEM RES, V146, P35, DOI 10.1007/s12011-011-9224-5
   Peacock M, 2010, CLIN J AM SOC NEPHRO, V5, pS23, DOI 10.2215/CJN.05910809
   Randell EW, 2008, ATHEROSCLEROSIS, V196, P413, DOI 10.1016/j.atherosclerosis.2006.11.024
   RESNICK LM, 1992, J AM SOC NEPHROL, V3, pS78
   RESNICK LM, 1992, AM J MED, V93, pS11, DOI 10.1016/0002-9343(92)90290-R
   RESNICK LM, 1993, AM J HYPERTENS, V6, pS123, DOI 10.1093/ajh/6.4S.123S
   RESNICK LM, 1991, HYPERTENSION, V17, P951, DOI 10.1161/01.HYP.17.6.951
   Richart T, 2011, AM J HYPERTENS, V24, P102, DOI 10.1038/ajh.2010.124
   Rotter I, 2015, INT J ENV RES PUB HE, V12, P3944, DOI 10.3390/ijerph120403944
   Sales CH, 2014, CLIN NUTR, V33, P879, DOI 10.1016/j.clnu.2013.10.004
   Saris NEL, 2000, CLIN CHIM ACTA, V294, P1, DOI 10.1016/S0009-8981(99)00258-2
   Secher M., 2012, Present knowledge in nutrition, P654
   Shin SK, 2015, NUTR RES PRACT, V9, P328, DOI 10.4162/nrp.2015.9.3.328
   Sun G, 2005, DIABETES, V54, P3336, DOI 10.2337/diabetes.54.11.3336
   Swaminathan R, 2003, Clin Biochem Rev, V24, P47
   Touyz R. M., 2003, Molecular Aspects of Medicine, V24, P107, DOI 10.1016/S0098-2997(02)00094-8
   Volpe SL, 2008, CRIT REV FOOD SCI, V48, P293, DOI 10.1080/10408390701326235
   Wennersberg MH, 2009, AM J CLIN NUTR, V90, P960, DOI 10.3945/ajcn.2009.27664
   WHITE RE, 1989, BIOCHEM PHARMACOL, V38, P859, DOI 10.1016/0006-2952(89)90272-4
   Wilcox Gisela, 2005, Clin Biochem Rev, V26, P19
   Xi B, 2013, PREV MED, V57, P867, DOI 10.1016/j.ypmed.2013.09.023
   Yamaguchi T, 2011, METABOLISM, V60, P1334, DOI 10.1016/j.metabol.2011.02.003
   Yu YH, 2012, NUTR RES, V32, P71, DOI 10.1016/j.nutres.2011.12.004
   Zemel MB, 1998, MOL CELL BIOCHEM, V188, P129, DOI 10.1023/A:1006880708475
   Zemel MB, 2000, FASEB J, V14, P1132, DOI 10.1096/fasebj.14.9.1132
   Zemel MB, 2001, J AM COLL NUTR, V20, p428S, DOI 10.1080/07315724.2001.10719180
NR 75
TC 22
Z9 23
U1 0
U2 6
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-6807
EI 1421-9697
J9 ANN NUTR METAB
JI Ann. Nutr. Metab.
PY 2016
VL 69
IS 2
BP 125
EP 134
DI 10.1159/000450761
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA EC8UC
UT WOS:000388417300056
PM 27750224
DA 2025-06-11
ER

PT J
AU Faganello, G
   Cioffi, G
   Faggiano, P
   Candido, R
   Tarantini, L
   De Feo, S
   Di Lenarda, A
   de Simone, G
AF Faganello, Giorgio
   Cioffi, Giovanni
   Faggiano, Pompilio
   Candido, Riccardo
   Tarantini, Luigi
   De Feo, Stefania
   Di Lenarda, Andrea
   de Simone, Giovanni
TI Does metabolic syndrome worsen systolic dysfunction in diabetes? The
   shortwave study
SO ACTA DIABETOLOGICA
LA English
DT Article
DE Diabetes mellitus; Metabolic syndrome; Cardiac function; Left
   ventricular systolic function
ID CORONARY-HEART-DISEASE; LEFT-VENTRICULAR GEOMETRY; OBSTRUCTIVE
   SLEEP-APNEA; MYOCARDIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; DIASTOLIC
   FUNCTION; SYNDROME IMPACT; HIGH PREVALENCE; MELLITUS; RISK
AB Patients with metabolic syndrome (MetS) have high cardiovascular event rates. The additional effect of MetS on left ventricular (LV) systolic function in patients with type 2 diabetes mellitus (T2DM) is unknown. We studied the relation between MetS and LV systolic function in T2DM patients without coronary artery disease (CAD). Clinical and echocardiographic data from 331 T2DM patients were analyzed. Prevalence of MetS was assessed based on NCEP ATPIII definition. Stress-corrected midwall shortening (sc-MS) and mitral annular peak systolic velocity (S') were analyzed as indexes of circumferential and longitudinal shortening, respectively. Sc-MS was impaired if < 89 %, S' if < 8.5 cm/s (10th percentile of healthy controls). MetS was diagnosed in 172 patients. Sc-MS and S' were similar in T2DM patients with and without MetS (91 +/- A 14 vs 92 +/- A 15 %; 9.8 +/- A 2.0 vs 9.5 +/- A 2.1 cm/s, respectively; p = ns) but significantly reduced comparing to controls (102 +/- A 11 % and 10.8 cm/s; p < 0.0001). Impairment of sc-MS and S' were detected in 37 vs 40 % and in 29 vs 32 % of T2DM patients with and without MetS (p = ns), respectively. LV systolic function measured as sc-MS and S' is frequently impaired in T2DM patients without CAD; however, the coexistence of MetS is not associated with more severe LV systolic dysfunction. Further pathological mechanisms have to be considered to explain the negative prognostic impact of MetS in T2DM patients.
C1 [Faganello, Giorgio; Di Lenarda, Andrea] Azienda Serv Sanit 1, Cardiovasc Ctr, I-34100 Trieste, Italy.
   [Cioffi, Giovanni] Villa Bianca Hosp, Dept Cardiol, Trento, Italy.
   [Faggiano, Pompilio] Spedali Civil Brescia, Cardiol Unit, I-25125 Brescia, Italy.
   [Candido, Riccardo] Azienda Serv Sanit 1, I-34100 Trieste, Italy.
   [Tarantini, Luigi] Osped Civile S Martino, Dept Cardiol, Belluno, Italy.
   [De Feo, Stefania] Pederzolli Hosp, Dept Cardiol, Peschiera, Italy.
   [de Simone, Giovanni] Univ Hosp, Dept Translat Med Sci, Naples, Italy.
C3 Hospital Spedali Civili Brescia; ULSS 1 Dolomiti; Ospedale di Belluno
RP Faganello, G (corresponding author), Azienda Serv Sanit 1, Cardiovasc Ctr, Via Slataper 9, I-34100 Trieste, Italy.
EM giorgio.faganello@libero.it
RI Tarantini, Luigi/AAY-9493-2021; Di Lenarda, Andrea/AAC-2377-2022;
   Candido, Riccardo/AAC-4525-2022; de Simone, Giovanni/D-1767-2011
OI tarantini, luigi/0000-0003-2580-0963; de Simone,
   Giovanni/0000-0001-8567-9881
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alexander CM, 2003, DIABETES, V52, P1210, DOI 10.2337/diabetes.52.5.1210
   Balkau B, 2002, DIABETES METAB, V28, P364
   Cioffi G, 2013, EXP CLIN CARDIOL, V18, pE26
   Cioffi G, 2012, EUR J PREV CARDIOL, V19, P935, DOI 10.1177/1741826711417759
   Cioffi G, 2011, EUR J ECHOCARDIOGR, V12, P61, DOI 10.1093/ejechocard/jeq106
   Crendal E, 2013, OBESITY, V21, pE679, DOI 10.1002/oby.20537
   de Simone G, 2005, HYPERTENSION, V45, P64, DOI 10.1161/01.HYP.0000150108.37527.57
   de Simone G, 2013, NUTR METAB CARDIOVAS, V23, P285, DOI 10.1016/j.numecd.2011.06.007
   de Simone G, 2007, DIABETES CARE, V30, P1851, DOI 10.2337/dc06-2152
   DESIMONE G, 1995, J AM COLL CARDIOL, V25, P1056, DOI 10.1016/0735-1097(94)00540-7
   DESIMONE G, 1994, J AM COLL CARDIOL, V23, P1444, DOI 10.1016/0735-1097(94)90390-5
   DEVEREUX RB, 1986, AM J CARDIOL, V57, P450, DOI 10.1016/0002-9149(86)90771-X
   Devereux RB, 2000, CIRCULATION, V101, P2271, DOI 10.1161/01.CIR.101.19.2271
   Faden G, 2013, DIABETES RES CLIN PR, V101, P309, DOI 10.1016/j.diabres.2013.07.004
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   Fournier SB, 2014, EXP PHYSIOL, V99, P149, DOI 10.1113/expphysiol.2013.075796
   Galderisi M, 2007, AM J HYPERTENS, V20, P548, DOI 10.1016/j.amjhyper.2006.12.009
   Grassi G, 2007, NUTR METAB CARDIOVAS, V17, P473, DOI 10.1016/j.numecd.2007.01.004
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Ha JW, 2007, HEART, V93, P1571, DOI 10.1136/hrt.2006.101667
   Ha Tae Hoon, 2011, J Cardiovasc Ultrasound, V19, P176, DOI 10.4250/jcu.2011.19.4.176
   Hiestand DM, 2006, CHEST, V130, P780, DOI 10.1378/chest.130.3.780
   Howard BV, 2006, DIABETES CARE, V29, P391, DOI 10.2337/diacare.29.02.06.dc05-1299
   Iozzo P, 2009, J CLIN ENDOCR METAB, V94, P4472, DOI 10.1210/jc.2009-0436
   Koyama Y, 2007, J CARD FAIL, V13, P199, DOI 10.1016/j.cardfail.2006.11.009
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Levey AS, 1999, ANN INTERN MED, V130, P461, DOI 10.7326/0003-4819-130-6-199903160-00002
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Mulè G, 2006, NUTR METAB CARDIOVAS, V16, P54, DOI 10.1016/j.numecd.2005.03.005
   Nagueh SF, 2009, EUR J ECHOCARDIOGR, V10, P165, DOI [10.1093/ejechocard/jep007, 10.1016/j.echo.2008.11.023]
   PARTINEN M, 1988, CHEST, V94, P1200, DOI 10.1378/chest.94.6.1200
   Peppard PE, 2000, NEW ENGL J MED, V342, P1378, DOI 10.1056/NEJM200005113421901
   Redfield MM, 2003, JAMA-J AM MED ASSOC, V289, P194, DOI 10.1001/jama.289.2.194
   Rijzewijk LJ, 2008, J AM COLL CARDIOL, V52, P1793, DOI 10.1016/j.jacc.2008.07.062
   Schillaci G, 2004, J AM COLL CARDIOL, V43, P1817, DOI 10.1016/j.jacc.2003.12.049
   Shamsuzzaman ASM, 2003, JAMA-J AM MED ASSOC, V290, P1906, DOI 10.1001/jama.290.14.1906
   Sohn DW, 1997, J AM COLL CARDIOL, V30, P474, DOI 10.1016/S0735-1097(97)88335-0
   Tadic M, 2013, CLIN EXP HYPERTENS, V35, P637, DOI 10.3109/10641963.2013.776573
   Tadic M, 2012, MED SCI MONITOR, V18, pCR282, DOI 10.12659/MSM.882733
   Tartan Z, 2008, NUTR METAB CARDIOVAS, V18, P441, DOI 10.1016/j.numecd.2007.02.015
   Willemsen S, 2011, EUR J HEART FAIL, V13, P76, DOI 10.1093/eurjhf/hfq168
   Yamaguchi T, 2013, CLIN EXP PHARMACOL P, V40, P443, DOI 10.1111/1440-1681.12107
NR 44
TC 4
Z9 4
U1 0
U2 2
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD FEB
PY 2015
VL 52
IS 1
BP 143
EP 151
DI 10.1007/s00592-014-0620-0
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CA9EQ
UT WOS:000349224100016
PM 25074251
DA 2025-06-11
ER

PT J
AU Li, SJ
   Liu, CH
   Chang, CW
   Chu, HP
   Chen, KJ
   Mersmann, HJ
   Ding, ST
   Chu, CH
   Chen, CY
AF Li, Sin-Jin
   Liu, Chia-Hsin
   Chang, Chei-Wei
   Chu, Hsien-Pin
   Chen, Kuen-Jaw
   Mersmann, Harry J.
   Ding, Shih-Torng
   Chu, Chun-Han
   Chen, Ching-Yi
TI Development of a dietary-induced metabolic syndrome model using
   miniature pigs involvement of AMPK and SIRT1
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE AMPK; Lanyu miniature pig; Lee-Sung miniature pig; metabolic syndrome;
   metabolically healthy obesity; SIRT1
ID OXIDATIVE STRESS; NONALCOHOLIC STEATOHEPATITIS; NORMAL-WEIGHT; HIGH-FAT;
   HEPATIC STEATOSIS; PORCINE MODELS; OBESE; HEALTHY; MICE; PROTECTS
AB BackgroundDuring the progression of the metabolic syndrome (MetS), cardiovascular diseases (CVD) appear clinically in many individuals and cause death. As a result, it is essential to set up an optimal animal model to study the mechanism of MetS leading to CVD. SIRT1 and AMPK are the master regulators of lipid and carbohydrate metabolism. The objective of this study was to establish a miniature pig model of Western diet-induced MetS and investigate the role of SIRT1/AMPK during MetS development.
   Materials and MethodsFive-month-old Lee-Sung (LS) and Lanyu (LY) minipigs were each randomly assigned to two groups: control diet (C) and Western diet (W), in a 6-month experimental period.
   ResultsWestern diet caused obesity in both minipig models. Compared with the CLS pigs, WLS pigs exhibited hypercholesterolaemia. However, WLY pigs maintained a similar plasma lipid profile to the CLY pigs. Western diet caused a lower antioxidant capacity in the liver of both pig models. WLS pigs had higher triglyceride accumulation in the liver than CLS pigs, whereas WLY and CLY pigs had similar hepatic triglyceride accumulation. Compared with CLS pigs, WLS pigs had a lower hepatic SIRT1 expression, whereas WLY pigs had a higher expression of AMPK, FOXO1 and SIRT1 than CLY pigs.
   ConclusionLong-term feeding of the Western diet to Lee-Sung miniature pigs not only caused obesity but also induced MetS and fatty liver, whereas Western diet induced obesity in Lanyu pigs without metabolic dysfunctions. SIRT1/AMPK and their downstream pathways might be one of the possible regulators for pathological obesity in Lee-Sung pigs.
C1 [Li, Sin-Jin; Liu, Chia-Hsin; Mersmann, Harry J.; Ding, Shih-Torng; Chu, Chun-Han; Chen, Ching-Yi] Natl Taiwan Univ, Dept Anim Sci & Technol, Taipei 106, Taiwan.
   [Chang, Chei-Wei; Chu, Hsien-Pin; Chen, Kuen-Jaw] Livestock Res Inst Council Agr, Taitung Anim Propagat Stn, Beinan Township, Taitung County, Taiwan.
   [Ding, Shih-Torng] Natl Taiwan Univ, Inst Biotechnol, Taipei 10764, Taiwan.
C3 National Taiwan University; National Taiwan University
RP Chen, CY (corresponding author), Natl Taiwan Univ, Dept Anim Sci & Technol, 50,Lane 155,Sec 3,Keelung Rd, Taipei 106, Taiwan.
EM ronichen@ntu.edu.tw
RI Liu, Chun-Yu/I-4358-2015
OI Chen, Ching-Yi/0000-0002-5776-084X; Li, Sin-Jin/0000-0002-0010-8439;
   Ding, Shih-Torng/0000-0002-9866-1776
FU National Science Council [NSC 101-2313-B-002-030-MY3]; National Taiwan
   University [NTU-CESRP-102R7615-1, NTU-CESRP-103R7615-3]
FX This work was supported by the Research Grant NSC 101-2313-B-002-030-MY3
   (from National Science Council), NTU-CESRP-102R7615-1 and
   NTU-CESRP-103R7615-3 (from National Taiwan University).
CR [Anonymous], 2013, OB OV FACT SHEET 311
   Appleton SL, 2013, DIABETES CARE, V36, P2388, DOI 10.2337/dc12-1971
   Banks AS, 2008, CELL METAB, V8, P333, DOI 10.1016/j.cmet.2008.08.014
   Cantó C, 2012, PHARMACOL REV, V64, P166, DOI 10.1124/pr.110.003905
   Cantó C, 2009, NATURE, V458, P1056, DOI 10.1038/nature07813
   Chen CY, 2010, EUR J HEART FAIL, V12, P323, DOI 10.1093/eurjhf/hfq028
   Deflandre CJ, 2008, VET ANAESTH ANALG, V35, P13, DOI 10.1111/j.1467-2995.2007.00346.x
   Egnatchik RA, 2014, MOL METAB, V3, P544, DOI 10.1016/j.molmet.2014.05.004
   Egnatchik RA, 2014, METABOLISM, V63, P283, DOI 10.1016/j.metabol.2013.10.009
   Han YH, 2014, ANTIOXID REDOX SIGN, V21, P2083, DOI 10.1089/ars.2013.5655
   Heinonen I, 2014, ACTA PHYSIOL, V211, P515, DOI 10.1111/apha.12253
   Herranz D, 2010, NAT REV CANCER, V10, P819, DOI 10.1038/nrc2962
   Hsieh YH, 2013, J SCI FOOD AGR, V93, P2758, DOI 10.1002/jsfa.6095
   Kim M, 2013, METABOLISM, V62, P554, DOI 10.1016/j.metabol.2012.10.006
   Lee J, 2010, AM J PHYSIOL-HEART C, V298, pH310, DOI 10.1152/ajpheart.00359.2009
   Lee L, 2009, HEPATOLOGY, V50, P56, DOI 10.1002/hep.22904
   Litten-Brown JC, 2010, ANIMAL, V4, P899, DOI 10.1017/S1751731110000200
   Lwow F, 2011, MENOPAUSE, V18, P646, DOI 10.1097/gme.0b013e3182038ec1
   Minato T, 2014, MOL MED, V20, P490, DOI 10.2119/molmed.2014.00048
   Nabeshima A, 2013, ANTIOXID REDOX SIGN, V19, P1983, DOI 10.1089/ars.2012.4946
   Pajunen P, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-754
   Pedersen R, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0056612
   Pfluger PT, 2008, P NATL ACAD SCI USA, V105, P9793, DOI 10.1073/pnas.0802917105
   Purushotham A, 2012, FASEB J, V26, P656, DOI 10.1096/fj.11-195172
   Purushotham A, 2009, CELL METAB, V9, P327, DOI 10.1016/j.cmet.2009.02.006
   Ruderman NB, 2013, J CLIN INVEST, V123, P2764, DOI 10.1172/JCI67227
   Ruderman NB, 2010, AM J PHYSIOL-ENDOC M, V298, pE751, DOI 10.1152/ajpendo.00745.2009
   Schmittgen TD, 2008, NAT PROTOC, V3, P1101, DOI 10.1038/nprot.2008.73
   Schug TT, 2011, ANN MED, V43, P198, DOI 10.3109/07853890.2010.547211
   Spurlock ME, 2008, J NUTR, V138, P397, DOI 10.1093/jn/138.2.397
   Tariq Z, 2014, LIVER INT, V34, pE180, DOI 10.1111/liv.12523
   Trask AJ, 2012, J APPL PHYSIOL, V113, P1128, DOI 10.1152/japplphysiol.00604.2012
   Voulgari C, 2011, J AM COLL CARDIOL, V58, P1343, DOI 10.1016/j.jacc.2011.04.047
   Wildman RP, 2008, ARCH INTERN MED, V168, P1617, DOI 10.1001/archinte.168.15.1617
   Xu XJ, 2013, CURR OPIN LIPIDOL, V24, P49, DOI 10.1097/MOL.0b013e32835b465b
NR 35
TC 15
Z9 16
U1 1
U2 23
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD JAN
PY 2015
VL 45
IS 1
BP 70
EP 80
DI 10.1111/eci.12370
PG 11
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA AX6UO
UT WOS:000347056700009
PM 25376184
DA 2025-06-11
ER

PT J
AU El-Bassossy, HM
   Hassan, N
   Zakaria, MNM
AF El-Bassossy, Hany M.
   Hassan, Nadia
   Zakaria, Mohamed N. M.
TI Heme oxygenase-1 alleviates vascular complications associated with
   metabolic syndrome: Effect on endothelial dependent relaxation and NO
   production
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article
DE Metabolic syndrome; Aorta; Hypertension; Haem oxygenase-1
ID NITRIC-OXIDE SYNTHASE; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   CARBON-MONOXIDE; INDUCTION PROTECTS; BLOOD-PRESSURE; HYPERTENSION;
   CELLS; INHIBITION; APOPTOSIS
AB Protective effect of Heme oxygenase-1 (HO-1) induction from hypertension was previously reported in a diabetic animal model. Here, the effect of HO-1 induction on vascular complications associated with metabolic syndrome (MetS) was investigated.
   MetS was induced in rats by fructose drinking for 12 weeks while HO-1 was induced by hemin or curcumin administration in the last 6 weeks. Then, aortic HO-1 protein expression was assessed, blood pressure (BP) was recorded and serum levels of glucose and insulin were measured. Concentration response curves for phenylephrine (PE), KCI, and acetylcholine (ACh) were obtained in thoracic aortic cross sections. Aortic reactive oxygen species (ROS) and nitric oxide (NO) generation were also studied.
   Both hemin and curcumin significantly inhibited the elevated systolic and diastolic BP seen in MetS animals. While not affected by MetS, HO-1 expression was significantly increased by hemin and curcumin treatment. HO-1 induction did not affect the exaggerated vasoconstriction response to KC] and PE. However, HO-1 induction prevented the impaired relaxation and NO generation in aorta isolated from MetS animals. In addition, the HO inhibitor, tin protoporphyrin, abolished the hemin protective effect on relaxation and NO generation. HO-1 induction prevented the elevated hyperinsulinemia associated with MetS. Furthermore, HO-1 induction inhibited ROS production in aorta isolated from MetS animals.
   In conclusion, Heme oxygenase-1 alleviates vascular complications associated in MetS through maintaining endothelial-dependent relaxation and NO generation in addition to improving insulin sensitivity. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [El-Bassossy, Hany M.] King Abdulaziz Univ, Fac Pharm, Dept Pharmacol, Jeddah 21589, Saudi Arabia.
   [El-Bassossy, Hany M.; Hassan, Nadia; Zakaria, Mohamed N. M.] Zagazig Univ, Fac Pharm, Dept Pharmacol, Alexandria, Egypt.
C3 King Abdulaziz University; Egyptian Knowledge Bank (EKB); Zagazig
   University
RP El-Bassossy, HM (corresponding author), King Abdulaziz Univ, Fac Pharm, Dept Pharmacol, POB 80260, Jeddah 21589, Saudi Arabia.
EM helbassossy@kau.edu.sa
RI El-Bassossy, Hany/NKQ-3705-2025; El-Bassossy, Hany/I-1576-2012
OI El-Bassossy, Hany/0000-0002-6838-6945
CR Abraham NG, 2005, FREE RADICAL BIO MED, V39, P1, DOI 10.1016/j.freeradbiomed.2005.03.010
   Ahmad M, 2005, CELL MOL BIOL, V51, P371, DOI 10.1170/T640
   Alam J, 2003, AM J PHYSIOL-RENAL, V284, pF743, DOI 10.1152/ajprenal.00376.2002
   Ansarullah, 2010, EUR J INTEGR MED, V2, P79, DOI 10.1016/j.eujim.2010.03.005
   Badawy D, 2013, CAN J PHYSIOL PHARM, V91, P101, DOI 10.1139/cjpp-2012-0232
   Conde de la Rosa L, 2008, FREE RADICAL BIO MED, V44, P1323, DOI 10.1016/j.freeradbiomed.2007.12.011
   DAI S, 1995, J PHARMACOL TOX MET, V33, P101, DOI 10.1016/1056-8719(94)00063-A
   DANIELSEN R, 1987, AM J CARDIOL, V60, P143, DOI 10.1016/0002-9149(87)91001-0
   Delbosc S, 2005, ATHEROSCLEROSIS, V179, P43, DOI 10.1016/j.atherosclerosis.2004.10.018
   El-Bassossy HM, 2014, TOXICOL MECH METHOD, V24, P536, DOI 10.3109/15376516.2014.945109
   El-Bassossy HM, 2013, BRIT J PHARMACOL, V169, P693, DOI 10.1111/bph.12144
   El-Bassossy HM, 2012, VASC PHARMACOL, V57, P194, DOI 10.1016/j.vph.2012.01.001
   El-Bassossy HM, 2011, FOOD CHEM TOXICOL, V49, P3007, DOI 10.1016/j.fct.2011.07.060
   El-Bassossy HM, 2011, N-S ARCH PHARMACOL, V384, P277, DOI 10.1007/s00210-011-0669-z
   El-Bassossy HM, 2009, BRIT J PHARMACOL, V158, P1527, DOI 10.1111/j.1476-5381.2009.00419.x
   ESCALANTE B, 1991, HYPERTENSION, V17, P776, DOI 10.1161/01.HYP.17.6.776
   Finkel T, 1998, CURR OPIN CELL BIOL, V10, P248, DOI 10.1016/S0955-0674(98)80147-6
   Hassan N, 2013, N-S ARCH PHARMACOL, V386, P217, DOI 10.1007/s00210-012-0822-3
   Hori R, 2002, J BIOL CHEM, V277, P10712, DOI 10.1074/jbc.M107749200
   Hsu JH, 2007, J ETHNOPHARMACOL, V112, P577, DOI 10.1016/j.jep.2007.05.013
   Iyer SN, 1996, CLIN EXP HYPERTENS, V18, P227, DOI 10.3109/10641969609081766
   Kanakiriya SKR, 2003, AM J PHYSIOL-RENAL, V284, pF546, DOI 10.1152/ajprenal.00298.2002
   Khoo NKH, 2010, FREE RADICAL BIO MED, V48, P230, DOI 10.1016/j.freeradbiomed.2009.10.046
   Kim HJ, 2006, FREE RADICAL BIO MED, V40, P1810, DOI 10.1016/j.freeradbiomed.2006.01.018
   Kojda G, 1999, CARDIOVASC RES, V42, P206, DOI 10.1016/S0008-6363(98)00315-0
   Laight DW, 2000, CARDIOVASC RES, V47, P457, DOI 10.1016/S0008-6363(00)00054-7
   Leffler CW, 1999, AM J PHYSIOL-HEART C, V276, pH1641, DOI 10.1152/ajpheart.1999.276.5.H1641
   Lind L, 2008, ATHEROSCLEROSIS, V196, P795, DOI 10.1016/j.atherosclerosis.2007.01.014
   Mahmoud MF, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0063784
   Mansour SM, 2011, PHYTOMEDICINE, V18, P641, DOI 10.1016/j.phymed.2011.01.014
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mellor K, 2010, NUTRITION, V26, P842, DOI 10.1016/j.nut.2009.08.017
   Mellor KM, 2011, J MOL CELL CARDIOL, V50, P1035, DOI 10.1016/j.yjmcc.2011.03.002
   Moseley P, 2000, IMMUNOPHARMACOLOGY, V48, P299, DOI 10.1016/S0162-3109(00)00227-7
   Ndisang JF, 2002, HYPERTENSION, V40, P315, DOI 10.1161/01.HYP.0000028488.71068.16
   Nisoli E, 2007, CIRC RES, V100, P795, DOI 10.1161/01.RES.0000259591.97107.6c
   Pae HO, 2010, NITRIC OXIDE-BIOL CH, V23, P251, DOI 10.1016/j.niox.2010.08.002
   Srivastava P, 1998, PHARMACOL RES, V38, P265, DOI 10.1006/phrs.1998.0357
   Steinberg HO, 1996, J CLIN INVEST, V97, P2601, DOI 10.1172/JCI118709
   Stocker R, 2004, ANTIOXID REDOX SIGN, V6, P841, DOI 10.1089/1523086041797999
   Stocker R, 2006, CIRCULATION, V114, P2178, DOI 10.1161/CIRCULATIONAHA.105.598698
   Suwannaphet W, 2010, FOOD CHEM TOXICOL, V48, P1853, DOI 10.1016/j.fct.2010.04.021
   Verma S, 1996, AM J HYPERTENS, V9, P370, DOI 10.1016/0895-7061(95)00392-4
   Visner GA, 2003, CIRCULATION, V107, P911, DOI 10.1161/01.CIR.0000048191.75585.60
   Wang X, 2007, J BIOL CHEM, V282, P1718, DOI 10.1074/jbc.M607610200
   Wu BJ, 2006, J EXP MED, V203, P1117, DOI 10.1084/jem.20052321
NR 46
TC 18
Z9 18
U1 0
U2 2
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD NOV 5
PY 2014
VL 223
BP 109
EP 115
DI 10.1016/j.cbi.2014.09.014
PG 7
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA AW6RZ
UT WOS:000346397400014
PM 25268984
DA 2025-06-11
ER

PT J
AU Salem, SD
   Saif-Ali, R
   Muniandy, S
   Al-Hamodi, Z
   Ismail, IS
AF Salem, Sameer D.
   Saif-Ali, Riyadh
   Muniandy, Sekaran
   Al-Hamodi, Zaid
   Ismail, Ikram S.
TI Comparison of Adults with Insulin Resistance (IR) in Latent Autoimmune
   Diabetes Versus IR in Glutamic Acid Decarboxylase Antibody-negative
   Diabetes
SO ANNALS ACADEMY OF MEDICINE SINGAPORE
LA English
DT Article
DE GAD-negative diabetes; Insulin resistance; LADA
ID CHRONIC OXIDATIVE STRESS; BETA-CELL FUNCTION; GLUCOSE TOXICITY; GAD;
   AUTOANTIBODIES; PREVALENCE; ONSET; LADA; POSITIVITY; MECHANISM
AB Introduction: Insulin resistance in latent autoimmune diabetes in adults (LADA) patients is controversial. The aim of this study was to evaluate insulin resistance and its related factors (metabolic syndrome parameters) among subjects with LADA and glutamic acid decarboxylase antibodies (GADA) negative diabetes, as well as the impact of these factors on insulin resistance. Materials and Methods: GADA levels were investigated in 1140 diabetic patients aged between 30 and 70 years. Insulin resistance and metabolic syndrome parameters were assessed in LADA and GAD-negative diabetic patients by general linear model. In addition, the impact of metabolic syndrome factors on insulin resistance was assessed in LADA and glutamic acid decarboxylase (GAD)-negative diabetic patients. Results: LADA was diagnosed in 33 subjects from 1140 Malaysian diabetic patients (prevalence = 2.9%). The results showed that LADA patients had higher insulin resistance and high density lipoprotein cholesterol (HDLc) (P = 0.003 and 0.00017 respectively) and lower body mass index (BMI) (P = 0.007) compared to GAD-negative diabetic patients. The HDLc was associated with decreased insulin resistance in LADA patients (P=0.041), whereas HbA1c, triacylglycerides (TG) and waist were associated with increased insulin resistance in GAD-negative diabetic patients (P=3.6x10(-12), 1.01x10(-5) and 0.004 respectively). HbA1c was highly associated with decreasing beta-cell function in both LADA (P = 0.009) and GAD-negative diabetic subjects (P=2.2x10(-28)). Conclusion: Insulin resistance is significantly higher in LADA than GAD-negative diabetic Malaysian subjects.
C1 [Salem, Sameer D.; Muniandy, Sekaran] Univ Malaya, Fac Med, Dept Mol Med, Kuala Lumpur 50603, Malaysia.
   [Salem, Sameer D.; Saif-Ali, Riyadh; Al-Hamodi, Zaid] Sanaa Univ, Fac Med, Dept Biochem, Sanaa, Yemen.
   [Ismail, Ikram S.] Univ Malaya, Med Ctr, Dept Med, Kuala Lumpur 50603, Malaysia.
C3 Universiti Malaya; Universiti Malaya
RP Salem, SD (corresponding author), Univ Malaya, Fac Med, Dept Mol Med, Prot Lab, Kuala Lumpur 50603, Malaysia.
EM sameersalem@yahoo.com
RI Ismail, Ikram/A-6329-2009; Alhamodi, Zaid/D-1359-2010; Salem,
   Sameer/G-3517-2011; Saif-Ali, Riyadh/C-1536-2010; MUNIANDY,
   SEKARAN/B-5345-2010; Ismail, Ikram Shah/B-8651-2010
OI Saif-Ali, Riyadh/0000-0002-0246-3856; MUNIANDY,
   SEKARAN/0000-0003-1310-3634; Ismail, Ikram Shah/0000-0001-8796-1936;
   Salem, Sameer/0000-0002-8269-9382
FU University of Malaya [UM RG350/11HTM, PV029/2012A]
FX We thank all the participants of this research and all nursing and
   medical staff at UMMC for their dedication in this study. The authors
   wish to thank University of Malaya for supporting this study with the
   research grants, UM RG350/11HTM and PV029/2012A.
CR [Anonymous], 2012, ISRN PHARM, DOI DOI 10.5402/2012/580202
   Behme MT, 2003, ANN NY ACAD SCI, V1005, P374, DOI 10.1196/annals.1288.062
   Brophy S, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006165
   Buzzetti R, 2007, DIABETES CARE, V30, P932, DOI 10.2337/dc06-1696
   Carlsson Å, 2000, J CLIN ENDOCR METAB, V85, P76, DOI 10.1210/jc.85.1.76
   Carlsson S, 2007, DIABETOLOGIA, V50, P55, DOI 10.1007/s00125-006-0518-7
   Cernea S, 2009, DIABETES CARE, V32, pS246, DOI 10.2337/dc09-S317
   Chiu HK, 2007, DIABETES RES CLIN PR, V77, P237, DOI 10.1016/j.diabres.2006.12.013
   Davis TME, 2000, DIABETIC MED, V17, P667, DOI 10.1046/j.1464-5491.2000.00359.x
   Donath MY, 2004, DIABETOLOGIA, V47, P581, DOI 10.1007/s00125-004-1336-4
   Gorus FK, 1997, DIABETOLOGIA, V40, P95, DOI 10.1007/s001250050648
   Inukai T, 1997, EXP CLIN ENDOCR DIAB, V105, P327, DOI 10.1055/s-0029-1211773
   Lee Seung-Hwan, 2009, Diabetes Res Clin Pract, V83, pe62, DOI 10.1016/j.diabres.2008.11.031
   Lethagen ÅL, 2002, J CLIN ENDOCR METAB, V87, P1177, DOI 10.1210/jc.87.3.1177
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Naik RG, 2009, J CLIN ENDOCR METAB, V94, P4635, DOI 10.1210/jc.2009-1120
   Nambam B, 2010, WORLD J DIABETES, V1, P111, DOI 10.4239/wjd.v1.i4.111
   Park Y, 2011, DIABETES-METAB RES, V27, P975, DOI 10.1002/dmrr.1278
   Qi XY, 2011, DIABETES CARE, V34, P66, DOI 10.2337/dc10-0488
   Robertson RP, 2007, CELL BIOCHEM BIOPHYS, V48, P139, DOI 10.1007/s12013-007-0026-5
   Robertson RP, 2003, DIABETES, V52, P581, DOI 10.2337/diabetes.52.3.581
   Robertson RP, 2004, J BIOL CHEM, V279, P42351, DOI 10.1074/jbc.R400019200
   Roh M-O, 2010, ACTA DIABETOLO, V47, P1
   Stenström G, 2005, DIABETES, V54, pS68, DOI 10.2337/diabetes.54.suppl_2.S68
   Szepietowska B, 2012, ARCH MED SCI, V8, P491, DOI 10.5114/aoms.2012.29405
   Tan JT, 2010, J CLIN ENDOCR METAB, V95, P390, DOI 10.1210/jc.2009-0688
   TSURUOKA A, 1995, DIABETES RES CLIN PR, V28, P191, DOI 10.1016/0168-8227(95)01101-I
   Tuomi T, 1999, DIABETES, V48, P150, DOI 10.2337/diabetes.48.1.150
   van Deutekom AW, 2008, DIABETIC MED, V25, P117, DOI 10.1111/j.1464-5491.2007.02316.x
   VANDEWALLE CL, 1995, J CLIN ENDOCR METAB, V80, P846, DOI 10.1210/jc.80.3.846
   Weir GC, 2001, DIABETES, V50, pS154, DOI 10.2337/diabetes.50.2007.S154
   Zinman B, 2004, DIABETES, V53, P3193, DOI 10.2337/diabetes.53.12.3193
NR 32
TC 6
Z9 6
U1 0
U2 1
PU ACAD MEDICINE SINGAPORE
PI REPUBLIC SINGAPORE
PA 142 NEIL RD, REPUBLIC SINGAPORE 088871, SINGAPORE
SN 0304-4602
J9 ANN ACAD MED SINGAP
JI Ann. Acad. Med. Singap.
PD FEB
PY 2014
VL 43
IS 2
BP 107
EP 112
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AD7KK
UT WOS:000333442500007
PM 24652431
DA 2025-06-11
ER

PT J
AU Korita, I
   Bulo, A
   Langlois, M
   Blaton, V
AF Korita, Irena
   Bulo, Anyla
   Langlois, Michel
   Blaton, Victor
TI INFLAMMATION MARKERS IN PATIENTS WITH CARDIOVASCULAR DISEASE AND
   METABOLIC SYNDROME
SO JOURNAL OF MEDICAL BIOCHEMISTRY
LA English
DT Article
DE metabolic syndrome; inflammation; oxidative stress; stenosis; HDL
   lipoproteins
ID LOW-DENSITY-LIPOPROTEIN; ATHEROSCLEROSIS; CHOLESTEROL; CORONARY;
   GUIDELINES; PLASMA; LDL
AB Background: The clinical value and the interrelationship of HDL and the metabolic syndrome were studied using plasma levels of TNF-alpha, IL 6, IL 10, IL 8, IL 1 beta, IL 2R in patients with cardiovascular stenosis.
   Methods: On the basis of exclusion criteria, we recruited 198 male and female patients aged 45 to 75 years with CVD and 43 patients with MS. Patients were subdivided into %stenosis according to the CASS guidelines. Lipids were measured on an Olympus AU640 analyzer. Ox-LDL was measured by the immunosorbent assay and MDA by HPLC. Cytokines were analysed with DPC Immulite 1000. Statistical tests were performed using SPSS for Windows, 14.0 & Medcalc.
   Results: Ox-LDL and apoB were significantly higher in the MS(+) patient group (88.7 U/L) compared to the MS(-) group (77.5 U/L). Ox-LDL showed a positive correlation (P=0.001) with LDL-C, apoB and MDA. There was a higher concentration of HDL in the patient group MS(-), which was confirmed by a non-significant (P=0.849) change of apoA(I) from 1.267 g/L in the MS(+) to 1.275 g/L in the MS(-) group. A light significant increase of IL 10 (P=0.05) in MS(+) patients was observed, and the other analysed inflammation markers were mostly unchanged. MS has no direct association with the cytokine production.
   Conclusions: Ox-LDL and apoB were significantly higher in the MS(+) patient group. In a multiple regression analysis for ox-LDL, apoB (P=0.003) emerged as a strong predictor of the ox-LDL concentration, independent of age, gender. BMI and smoking.
C1 [Korita, Irena; Bulo, Anyla] Univ Hosp Ctr Mother Teresa, Dept Lab, Fac Med, Tirana, Albania.
   [Langlois, Michel; Blaton, Victor] AZ St Jan AV Dept Clin Chem Brugge, Brugge, Belgium.
   [Langlois, Michel; Blaton, Victor] Katholieke Univ Leuven, Louvain, Belgium.
C3 University Hospital Center Mother Teresa (QSUT); KU Leuven
RP Korita, I (corresponding author), Univ Hosp Ctr Mother Teresa, Dept Lab, RR Dibres 372, Tirana, Albania.
EM irenakorita@yahoo.it
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Blaton VH, 2008, BIOCHEM MEDICA, V18, P14
   Bossuyt PMM, 2011, J MED BIOCHEM, V30, P193, DOI 10.2478/v10011-011-0028-0
   BOZZI G, 1989, Giornale Italiano di Cardiologia, V19, P598
   Brouwers A, 2004, ATHEROSCLEROSIS, V176, P189, DOI 10.1016/j.atherosclerosis.2004.05.005
   Catapano AL, 2011, ATHEROSCLEROSIS, V217, P3, DOI 10.1016/j.atherosclerosis.2011.06.028
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Erren M, 1999, ARTERIOSCL THROM VAS, V19, P2355, DOI 10.1161/01.ATV.19.10.2355
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Graham I, 2007, EUR HEART J, V28, P2375, DOI 10.1093/eurheartj/ehm316
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Holvoet P, 2001, ARTERIOSCL THROM VAS, V21, P844, DOI 10.1161/01.ATV.21.5.844
   Hossain P, 2007, NEW ENGL J MED, V356, P213, DOI 10.1056/NEJMp068177
   Laaksonen DE, 2002, AM J EPIDEMIOL, V156, P1070, DOI 10.1093/aje/kwf145
   Langlois MR, 2008, ARTERIOSCL THROM VAS, V28, P1563, DOI 10.1161/ATVBAHA.108.167346
   Langlois MR, 2006, CLIN CHIM ACTA, V369, P168, DOI 10.1016/j.cca.2006.01.031
   Libby P, 2002, NATURE, V420, P868, DOI 10.1161/ATVBAHA.108.179705
   Mahmoudi M, 2007, HISTOPATHOLOGY, V50, P535, DOI 10.1111/j.1365-2559.2006.02503.x
   Majkic-Singh N, 2011, J MED BIOCHEM, V30, P186, DOI 10.2478/v10011-011-0029-z
   Reaven G, 2004, ENDOCRIN METAB CLIN, V33, P283, DOI 10.1016/j.ecl.2004.03.002
   Ridker PM, 2000, NEW ENGL J MED, V342, P836, DOI 10.1056/NEJM200003233421202
   Shakouri P, 2008, CARDIOVASC ULTRASOUN, V30, P6
   Sypniewska G, 2011, J MED BIOCHEM, V30, P237, DOI 10.2478/v10011-011-0022-6
   Tedgui A, 2006, PHYSIOL REV, V86, P515, DOI 10.1152/physrev.00024.2005
   Vandermeersch A, 2010, CLIN CHIM ACTA, V411, P1361, DOI 10.1016/j.cca.2010.05.038
   Verhoye E, 2009, CLIN CHEM LAB MED, V47, P128, DOI 10.1515/CCLM.2009.037
   WONG SHY, 1987, CLIN CHEM, V33, P214
NR 27
TC 10
Z9 11
U1 0
U2 12
PU SCIENDO
PI WARSAW
PA DE GRUYTER POLAND SP Z O O, BOGUMILA ZUGA 32A STR, 01-811 WARSAW, POLAND
SN 1452-8258
EI 1452-8266
J9 J MED BIOCHEM
JI J. Med. Biochem.
PD JUL-SEP
PY 2013
VL 32
IS 3
BP 214
EP 219
DI 10.2478/jomb-2013-0016
PG 6
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 187EC
UT WOS:000322098700003
OA gold
DA 2025-06-11
ER

PT J
AU Ashraf, GM
   Chibber, S
   Mohammad
   Zaidi, SK
   Tabrez, S
   Ahmad, A
   Shakil, S
   Mushtaq, G
   Baeesa, SS
   Kamal, MA
AF Ashraf, Ghulam M.
   Chibber, Sandesh
   Mohammad
   Zaidi, Syed K.
   Tabrez, Shams
   Ahmad, Ausaf
   Shakil, Shazi
   Mushtaq, Gohar
   Baeesa, Saleh S.
   Kamal, Mohammad A.
TI Recent Updates on the Association Between Alzheimer's Disease and
   Vascular Dementia
SO MEDICINAL CHEMISTRY
LA English
DT Article
DE Alzheimer's disease; dementia; insulin resistance syndrome; nitric
   oxide; reactive oxygen species; therapy; vascular dementia
ID ENDOTHELIAL GROWTH-FACTOR; GOAT HEART GALECTIN-1; CELL-DEATH MECHANISMS;
   CEREBRAL-BLOOD-FLOW; NITRIC-OXIDE; APOLIPOPROTEIN-E; OXIDATIVE STRESS;
   AMYLOID-BETA; INSULIN-RESISTANCE; MOUSE MODEL
AB The two most common forms of dementia are Alzheimer's disease (AD) followed by vascular dementia (VaD), together accounting for a whopping 60-80% of total dementia cases worldwide. Even though these diseases are recognized as 'common', they still remain underdiagnosed. Recent research suggests that AD and VaD are closely intertwined. The symptoms of AD and VaD can be similar and the two conditions can occur simultaneously. A large number of patients diagnosed with AD have also been reported with VaD-caused brain damage. Moreover, both the diseases have been reported to have similar risk factors. The overlap between these diseases is important because the lifestyle changes and medications prescribed to curb one of these diseases may also help curb the other. In the present review, we present an inclusive outline of the parallelism between AD and VaD by exploring potential commonalities at the mechanistic and therapeutic levels.
C1 [Ashraf, Ghulam M.; Tabrez, Shams] King Abdulaziz Univ, King Fahd Med Res Ctr, POB 80216, Jeddah 21589, Saudi Arabia.
   [Chibber, Sandesh] Ahmedabad Univ, Inst Life Sci, Ahmadabad, Gujarat, India.
   [Mohammad] Indian Inst Technol, Dept Biosci & Bioenegineering BSBE, Mumbai, Maharashtra, India.
   [Zaidi, Syed K.] King Abdulaziz Univ, Ctr Excellence Genom Med Res, Jeddah 21413, Saudi Arabia.
   [Ahmad, Ausaf] Amity Univ Uttar Pradesh, Amity Inst Biotechnol, Lucknow, Uttar Pradesh, India.
   [Shakil, Shazi] King Abdulaziz Univ, KACST Technol Innovat Ctr Personalized Med, Jeddah 21413, Saudi Arabia.
   [Shakil, Shazi] King Abdulaziz Univ, Fac Appl Med Sci, Dept Med Lab Technol, Jeddah 21413, Saudi Arabia.
   [Mushtaq, Gohar] King Abdulaziz Univ, Coll Sci, Dept Biochem, Jeddah 21413, Saudi Arabia.
   [Baeesa, Saleh S.] King Abdulaziz Univ, Coll Med, Div Neurosurg, Jeddah 21413, Saudi Arabia.
   [Kamal, Mohammad A.] Enzymoics, 7 Peterlee Pl, Hebersham, NSW 2770, Australia.
C3 King Abdulaziz University; Ahmedabad University; Indian Institute of
   Technology System (IIT System); Indian Institute of Technology (IIT) -
   Bombay; King Abdulaziz University; King Abdulaziz University; King
   Abdulaziz University; King Abdulaziz University; King Abdulaziz
   University
RP Ashraf, GM (corresponding author), King Abdulaziz Univ, King Fahd Med Res Ctr, POB 80216, Jeddah 21589, Saudi Arabia.
EM gashraf@kau.edu.sa
RI Ahmad, Ausaf/AGU-5341-2022; Mushtaq, Gohar/GPP-1327-2022; Baeesa,
   Saleh/G-5519-2011; Chibber, Sandesh/ABD-5851-2021; Tabrez,
   Shams/H-9476-2012; Mushtaq, Gohar/G-5504-2015; Ashraf, Ghulam
   Md/H-9485-2012; Zaidi, Syed Kashif/A-6160-2013; Kamal, Mohammad
   Amjad/J-2918-2014; Shakil, Shazi/K-4132-2015
OI Tabrez, Shams/0000-0003-4550-415X; Mushtaq, Gohar/0000-0003-4880-4035;
   Ashraf, Ghulam Md/0000-0002-9820-2078; Zaidi, Syed
   Kashif/0000-0003-2391-414X; Baeesa, Saleh/0000-0002-3053-7912; Kamal,
   Mohammad Amjad/0000-0003-0088-0565; AHMAD, AUSAF/0000-0002-1026-497X;
   Shakil, Shazi/0000-0003-4075-9153
CR Adibhatla Rao Muralikrishna, 2008, V49, P241, DOI 10.1007/978-1-4020-8831-5_9
   Ahmad A., 2013, MED PLANTS, V5, P1
   Ahmad A, 2012, PHYTOMEDICINE, V19, P639, DOI 10.1016/j.phymed.2012.02.012
   Ahmad A, 2012, CAN J NEUROL SCI, V39, P311, DOI 10.1017/S0317167100013433
   Akiyama H, 2000, NEUROBIOL AGING, V21, P383, DOI 10.1016/S0197-4580(00)00124-X
   Ali R, 2012, ANTICANCER RES, V32, P2999
   Aliev G, 2014, CURR MED CHEM, V21, P2208, DOI 10.2174/0929867321666131227161303
   Aliev G., 2014, SYSTEMS BIOL FREE RA, P2325
   Aliev G., 2014, SYSTEMS BIOL FREE RA, P2033
   Aliev G., 2014, SYSTEMS BIOL FREE RA, P2023
   Aliev G, 2013, AM J ALZHEIMERS DIS, V28, P660, DOI 10.1177/1533317513504614
   Angelopoulos P, 2008, INT J NEUROSCI, V118, P1659, DOI 10.1080/00207450701392068
   Ashraf GM, 2010, BIOCHEMISTRY-MOSCOW+, V75, P1450, DOI 10.1134/S0006297910120059
   Ashraf G.M., 2011, GALECTINS RES OVERVI
   Ashraf GM, 2014, CNS NEUROL DISORD-DR, V13, P1280, DOI 10.2174/1871527313666140917095514
   Ashraf GM, 2015, SAUDI J BIOL SCI, V22, P112, DOI 10.1016/j.sjbs.2014.09.018
   Ashraf GM, 2015, SAUDI J BIOL SCI, V22, P85, DOI 10.1016/j.sjbs.2014.07.008
   Ashraf GM, 2015, ADV EXP MED BIOL, V822, P67, DOI 10.1007/978-3-319-08927-0_10
   Ashraf GM, 2011, PROTEIN J, V30, P39, DOI 10.1007/s10930-010-9300-2
   Ashraf GM, 2010, AMINO ACIDS, V39, P1321, DOI 10.1007/s00726-010-0574-7
   Atzori C, 2001, J NEUROPATH EXP NEUR, V60, P1190, DOI 10.1093/jnen/60.12.1190
   Auchus AP, 2007, NEUROLOGY, V69, P448, DOI 10.1212/01.wnl.0000266625.31615.f6
   Avramopoulos D, 2009, GENOME MED, V1, DOI 10.1186/gm34
   Axen KV, 2003, J NUTR, V133, P2244, DOI 10.1093/jn/133.7.2244
   Balk Ethan, 2006, Evid Rep Technol Assess (Full Rep), P1
   Ballatore C, 2007, NAT REV NEUROSCI, V8, P663, DOI 10.1038/nrn2194
   Banu S, 2015, SAUDI J BIOL SCI, V22, P32, DOI 10.1016/j.sjbs.2014.04.005
   Barsoum MJ, 2006, EMBO J, V25, P3900, DOI 10.1038/sj.emboj.7601253
   Bayés A, 2009, NAT REV NEUROSCI, V10, P635, DOI 10.1038/nrn2701
   BECKMAN JS, 1993, NATURE, V364, P584, DOI 10.1038/364584a0
   Bennett S, 2009, J ALZHEIMERS DIS, V17, P245, DOI 10.3233/JAD-2009-1041
   Biolo A, 2009, P NATL ACAD SCI USA, V106, P1926, DOI 10.1073/pnas.0812381106
   Birks J, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005593
   Blasko I, 2004, AGING CELL, V3, P169, DOI 10.1111/j.1474-9728.2004.00101.x
   Blaylock R.L., 2011, SURG NEUROL INT, V2, P1
   Blaylock RL, 2012, SURG NEUROL INT, V3, P1
   Boden G, 2008, ENDOCRIN METAB CLIN, V37, P635, DOI 10.1016/j.ecl.2008.06.007
   Bookheimer SY, 2000, NEW ENGL J MED, V343, P450, DOI 10.1056/NEJM200008173430701
   Borlongan CV, 2005, BRAIN RES, V1038, P50, DOI 10.1016/j.brainres.2005.01.028
   Bossy-Wetzel E, 2004, NEURON, V41, P351, DOI 10.1016/S0896-6273(04)00015-7
   Bramlett HM, 2004, J CEREBR BLOOD F MET, V24, P133, DOI 10.1097/01.WCB.0000111614.19196.04
   Bravata DM, 2004, J CLIN EPIDEMIOL, V57, P1214, DOI 10.1016/j.jclinepi.2004.05.001
   Bray GA, 2002, J NUTR, V132, P2488, DOI 10.1093/jn/132.9.2488
   Brecht WJ, 2004, J NEUROSCI, V24, P2527, DOI 10.1523/JNEUROSCI.4315-03.2004
   Brown GC, 2004, BBA-BIOENERGETICS, V1658, P44, DOI 10.1016/j.bbabio.2004.03.016
   Bruunsgaard H, 2006, DAN MED BULL, V53, P285
   Bull R, 2008, J NEUROSCI, V28, P9463, DOI 10.1523/JNEUROSCI.2286-08.2008
   Cam JA, 2006, MOL NEURODEGENER, V1, DOI 10.1186/1750-1326-1-8
   Campbell IL, 1998, NEUROIMMUNOMODULAT, V5, P126, DOI 10.1159/000026329
   Cañuelo A, 2007, EXP GERONTOL, V42, P1137, DOI 10.1016/j.exger.2007.09.006
   Caro J, 2003, BMC GERIATR, V3, P1
   Cedazo-Mínguez A, 2001, J CELL MOL MED, V5, P254, DOI 10.1111/j.1582-4934.2001.tb00159.x
   Chan A, 2009, J NEUROCHEM, V110, P831, DOI 10.1111/j.1471-4159.2009.06177.x
   Cheal KL, 2004, DIABETES, V53, P1195, DOI 10.2337/diabetes.53.5.1195
   Chibber S., 2015, CNS NEUROL IN PRESS
   Cho DH, 2009, SCIENCE, V324, P102, DOI 10.1126/science.1171091
   Choi K, 2009, CURR NEUROVASC RES, V6, P213, DOI 10.2174/156720209789630375
   Christen Y, 2000, AM J CLIN NUTR, V71, p621S, DOI 10.1093/ajcn/71.2.621s
   Coppedè F, 2010, CURR GENOMICS, V11, P246, DOI 10.2174/138920210791233090
   Correia SC, 2010, FRONT AGING NEUROSCI, V2, DOI 10.3389/fnagi.2010.00138
   Craft S, 2009, ARCH NEUROL-CHICAGO, V66, P300, DOI 10.1001/archneurol.2009.27
   de la Monte SM, 2012, CURR ALZHEIMER RES, V9, P35
   Dickson DW, 2007, AM J PATHOL, V170, P16, DOI 10.2353/ajpath.2007.061011
   Dimopoulos N, 2006, IN VIVO, V20, P895
   Dolev I, 2004, P NATL ACAD SCI USA, V101, P13909, DOI 10.1073/pnas.0404458101
   Duarte AI, 2013, BBA-MOL BASIS DIS, V1832, P527, DOI 10.1016/j.bbadis.2013.01.008
   Duron E, 2008, VASC HEALTH RISK MAN, V4, P363
   Enciu Ana-Maria, 2011, J Aging Res, V2011, P401604, DOI 10.4061/2011/401604
   Erusalimsky JD, 2007, ARTERIOSCL THROM VAS, V27, P2524, DOI 10.1161/ATVBAHA.107.151167
   Everitt AV, 2006, CLIN INTERV AGING, V1, P11, DOI 10.2147/ciia.2006.1.1.11
   Farfara D, 2008, J CELL MOL MED, V12, P762, DOI 10.1111/j.1582-4934.2008.00314.x
   Fassbender K, 1999, STROKE, V30, P1647, DOI 10.1161/01.STR.30.8.1647
   Ferreiro E, 2006, NEUROBIOL DIS, V23, P669, DOI 10.1016/j.nbd.2006.05.011
   Frost B, 2009, J BIOL CHEM, V284, P12845, DOI 10.1074/jbc.M808759200
   Gathercole LL, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026223
   Goedert M, 2006, ALZHEIMER'S DISEASE: A CENTURY OF SCIENTIFIC AND CLINICAL RESEARCH, P195
   Grammas P, 2002, J ALZHEIMERS DIS, V4, P217, DOI 10.3233/JAD-2002-4311
   GRUNDKEIQBAL I, 1986, P NATL ACAD SCI USA, V83, P4913, DOI 10.1073/pnas.83.13.4913
   Grundy Scott M, 2006, Clin Cornerstone, V8 Suppl 1, pS21, DOI 10.1016/S1098-3597(06)80005-0
   Guo JL, 2011, J BIOL CHEM, V286, P15317, DOI 10.1074/jbc.M110.209296
   Hanrahan JR, 2011, BRIT J PHARMACOL, V163, P234, DOI 10.1111/j.1476-5381.2011.01228.x
   Harris FM, 2003, P NATL ACAD SCI USA, V100, P10966, DOI 10.1073/pnas.1434398100
   Hartman RE, 2002, J NEUROSCI, V22, P10083
   Hasan S, 2011, BIOL TRACE ELEM RES, V142, P589, DOI 10.1007/s12011-010-8771-5
   Hasan SS, 2007, CANCER LETT, V253, P25, DOI 10.1016/j.canlet.2006.11.030
   Herrmann N, 2002, CAN J PSYCHIAT, V47, P715, DOI 10.1177/070674370204700802
   Hildreth KL, 2012, OBESITY, V20, P1549, DOI 10.1038/oby.2012.19
   Himmelstein DS, 2012, PHARMACOL THERAPEUT, V136, P8, DOI 10.1016/j.pharmthera.2012.07.001
   Hsieh HL, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/484613
   Hu DY, 2006, J NEUROSCI, V26, P3933, DOI 10.1523/JNEUROSCI.5566-05.2006
   Hull M, 1996, BEHAV BRAIN RES, V78, P37, DOI 10.1016/0166-4328(95)00213-8
   Iadecola C, 2009, STROKE, V40, pS40, DOI 10.1161/STROKEAHA.108.533638
   Jabir NR, 2015, CNS NEUROSCI THER, V21, P1, DOI 10.1111/cns.12344
   Jabir NR, 2012, INT J NANOMED, V7, P4391, DOI 10.2147/IJN.S33838
   Kalani A, 2014, J MOL NEUROSCI, V52, P202, DOI 10.1007/s12031-013-0122-5
   Kalaria RN, 2010, NUTR REV, V68, pS74, DOI 10.1111/j.1753-4887.2010.00352.x
   Kalaria RN, 1999, ALZ DIS ASSOC DIS, V13, pS115, DOI 10.1097/00002093-199912003-00017
   Kaminsky YG, 2013, AGING DIS, V4, P244, DOI 10.14336/AD.2013.0400244
   Kemp JA, 2002, NAT NEUROSCI, V5, P1039, DOI 10.1038/nn936
   Kennedy KM, 2009, FRONT HUM NEUROSCI, V3, DOI 10.3389/neuro.09.019.2009
   Khan NM, 2014, CNS NEUROL DISORD-DR, V13, P1440, DOI 10.2174/1871527313666141023160448
   Kim DH, 2007, J PHARMACOL SCI, V105, P82, DOI 10.1254/jphs.FP0061565
   Klein RC, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094071
   Kleinridders A, 2014, DIABETES, V63, P2232, DOI 10.2337/db14-0568
   Knoch ME, 2008, GLIA, V56, P89, DOI 10.1002/glia.20592
   Koch Horst J., 2005, Current Drug Targets - CNS and Neurological Disorders, V4, P499, DOI 10.2174/156800705774322021
   KRONCKE KD, 1994, BIOCHEM BIOPH RES CO, V200, P1105, DOI 10.1006/bbrc.1994.1564
   Kruman II, 2002, J NEUROSCI, V22, P1752, DOI 10.1523/JNEUROSCI.22-05-01752.2002
   Kuang X, 2006, BRAIN RES, V1102, P145, DOI 10.1016/j.brainres.2006.04.110
   Kuang X, 2008, PHARMACOL BIOCHEM BE, V88, P213, DOI 10.1016/j.pbb.2007.08.006
   Kulstad JJ, 2006, NEUROLOGY, V66, P1506, DOI 10.1212/01.wnl.0000216274.58185.09
   Kumar Arun H S, 2011, J Nat Sci Biol Med, V2, P1, DOI 10.4103/0976-9668.82303
   Kumar V, 2000, EUR J NEUROL, V7, P159, DOI 10.1046/j.1468-1331.2000.00046.x
   Kumaran D, 2008, NEUROSCIENCE, V155, P626, DOI 10.1016/j.neuroscience.2008.06.023
   Kuo YM, 2000, MOL MED, V6, P430, DOI 10.1007/BF03401785
   Lewerin C, 2005, AM J CLIN NUTR, V81, P1155
   Li Y, 2011, ALZHEIMERS DEMENT, V7, pE47
   Liraz O, 2013, MOL NEURODEGENER, V8, DOI 10.1186/1750-1326-8-16
   Liu CC, 2013, NAT REV NEUROL, V9, P106, DOI 10.1038/nrneurol.2012.263
   Manavalan A, 2013, EXP MOL MED, V45, DOI 10.1038/emm.2013.76
   Mander P, 2004, BIOCHEM SOC T, V32, P1068, DOI 10.1042/BST0321068
   Martin LJ, 2010, PHARMACEUTICALS-BASE, V3, P839, DOI 10.3390/ph3040839
   Martin LJ, 2002, NEUROCHEM RES, V27, P1093, DOI 10.1023/A:1020961006216
   MATSUDA H, 1984, STROKE, V15, P336, DOI 10.1161/01.STR.15.2.336
   Mirza Z, 2014, CNS NEUROL DISORD-DR, V13, P213, DOI 10.2174/18715273113126660144
   Mishra S, 2008, ANN INDIAN ACAD NEUR, V11, P13, DOI 10.4103/0972-2327.40220
   Moreno MD, 2003, CLIN THER, V25, P178
   Moss DE, 1999, ALZ DIS ASSOC DIS, V13, P20, DOI 10.1097/00002093-199903000-00003
   Mungrue IN, 2003, ACTA PHYSIOL SCAND, V179, P123, DOI 10.1046/j.1365-201X.2003.01182.x
   Munoz L, 2007, J NEUROINFLAMM, V4, DOI 10.1186/1742-2094-4-21
   Nielsen TS, 2014, DIABETES, V63, P847, DOI 10.2337/db13-1838
   Nizri E, 2006, NEUROPHARMACOLOGY, V50, P540, DOI 10.1016/j.neuropharm.2005.10.013
   Olivares D, 2012, CURR ALZHEIMER RES, V9, P746
   Pacher P, 2007, PHYSIOL REV, V87, P315, DOI 10.1152/physrev.00029.2006
   Patel NS, 2010, J NEUROCHEM, V112, P66, DOI 10.1111/j.1471-4159.2009.06426.x
   Paulson JB, 2008, AM J PATHOL, V173, P762, DOI 10.2353/ajpath.2008.080175
   Perveen A, 2015, ADV EXP MED BIOL, V822, P37, DOI 10.1007/978-3-319-08927-0_7
   Peter K, 1997, ARTERIOSCL THROM VAS, V17, P505, DOI 10.1161/01.ATV.17.3.505
   Pettigrew LC, 2008, J NEUROINFLAMM, V5, DOI 10.1186/1742-2094-5-47
   Pichardo D, 2012, ANESTHESIOLOGY, V117, P15, DOI 10.1097/ALN.0b013e318259a8cc
   Piers LS, 2002, INT J OBESITY, V26, P814, DOI 10.1038/sj.ijo.0801993
   Pirson AS, 2006, AM J NEURORADIOL, V27, P1161
   Polymenidou M, 2012, J EXP MED, V209, P889, DOI 10.1084/jem.20120741
   Rahman A, 2005, FEBS LETT, V579, P6411, DOI 10.1016/j.febslet.2005.10.024
   Rapoport M, 2002, P NATL ACAD SCI USA, V99, P6364, DOI 10.1073/pnas.092136199
   Rascovsky K, 2011, BRAIN, V134, P2456, DOI 10.1093/brain/awr179
   Ravaglia G, 2007, NEUROBIOL AGING, V28, P1810, DOI 10.1016/j.neurobiolaging.2006.08.012
   Raza M, 2007, NEUROSCI LETT, V418, P77, DOI 10.1016/j.neulet.2007.03.005
   Recuero M, 2009, AGING CELL, V8, P128, DOI 10.1111/j.1474-9726.2009.00457.x
   Reddy PH, 2014, J ALZHEIMERS DIS, V40, P245, DOI 10.3233/JAD-132060
   Reddy PH, 2010, J ALZHEIMERS DIS, V20, pS499, DOI 10.3233/JAD-2010-100504
   Reynolds MR, 2005, BIOCHEMISTRY-US, V44, P1690, DOI 10.1021/bi047982v
   Ritz MF, 2009, CURR NEUROVASC RES, V6, P279, DOI 10.2174/156720209789630311
   Roman Gustavo C, 2005, Curr Psychiatry Rep, V7, P18, DOI 10.1007/s11920-005-0019-2
   Sagare A, 2007, NAT MED, V13, P1029, DOI 10.1038/nm1635
   Saha RN, 2003, J NEUROCHEM, V86, P1057, DOI 10.1046/j.1471-4159.2003.01942.x
   Savage DB, 2007, PHYSIOL REV, V87, P507, DOI 10.1152/physrev.00024.2006
   Schaller BJ, 2007, MOL IMAGING BIOL, V9, P60, DOI 10.1007/s11307-006-0069-9
   Schuff N, 2009, ALZHEIMERS DEMENT, V5, P454, DOI 10.1016/j.jalz.2009.04.1233
   Scorziello A, 2004, J NEUROSCI RES, V76, P812, DOI 10.1002/jnr.20096
   Selkoe DJ, 2002, SCIENCE, V298, P789, DOI 10.1126/science.1074069
   Sepulveda-Falla D, 2011, BRAIN PATHOL, V21, P452, DOI 10.1111/j.1750-3639.2010.00469.x
   Sergeant N, 2003, NEUROSCIENCE, V117, P293, DOI 10.1016/S0306-4522(02)00747-9
   Shakil S, 2013, ENZYME ENG, V2, P1
   Shankar GM, 2009, MOL NEURODEGENER, V4, DOI 10.1186/1750-1326-4-48
   Sharma A, 2011, INTERDISCIP SCI, V3, P232, DOI 10.1007/s12539-011-0102-9
   Shea TB, 2002, MOL BRAIN RES, V108, P1, DOI 10.1016/S0169-328X(02)00412-6
   Sheng M, 2012, CSH PERSPECT BIOL, V4, DOI 10.1101/cshperspect.a005777
   Shi QL, 2007, ALZ DIS ASSOC DIS, V21, P276, DOI 10.1097/WAD.0b013e31815721c3
   Shooshtari MK, 2012, IRAN J BASIC MED SCI, V15, P1173
   Solerte SB, 2005, DEMENT GERIATR COGN, V19, P1, DOI 10.1159/000080963
   Soung DY, 2004, J MED FOOD, V7, P84, DOI 10.1089/109662004322984752
   STRITTMATTER WJ, 1994, EXP NEUROL, V125, P163, DOI 10.1006/exnr.1994.1019
   Sultana R, 2007, J ALZHEIMERS DIS, V11, P153
   Tabrez S, 2013, J ENVIRON SCI HEAL C, V31, P67, DOI 10.1080/10590501.2013.763577
   Tai LM, 2013, J BIOL CHEM, V288, P5914, DOI 10.1074/jbc.M112.442103
   Tampi Rajesh R, 2007, Neuropsychiatr Dis Treat, V3, P245, DOI 10.2147/nedt.2007.3.2.245
   Toescu EC, 2005, PHILOS T R SOC B, V360, P2347, DOI 10.1098/rstb.2005.1771
   Togo T, 2004, NEUROL RES, V26, P563, DOI 10.1179/016164104225016236
   Turrens JF, 2003, J PHYSIOL-LONDON, V552, P335, DOI 10.1113/jphysiol.2003.049478
   Uttara B, 2009, CURR NEUROPHARMACOL, V7, P65, DOI 10.2174/157015909787602823
   Valko M, 2005, CURR MED CHEM, V12, P1161, DOI 10.2174/0929867053764635
   VanFossen BT, 2010, J ALZHEIMERS DIS, V19, P1149, DOI [10.3233/JAD-2009-1319, 10.3233/JAD-2010-1319]
   Villanueva I, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/218145
   von Bernhardi R, 2007, NEUROBIOL DIS, V26, P153, DOI 10.1016/j.nbd.2006.12.006
   Wang J, 2009, ACTA PHARMACOL SIN, V30, P879, DOI 10.1038/aps.2009.82
   WARNOCK LG, 1968, J NUTR, V94, P256, DOI 10.1093/jn/94.2.256
   Watson GS, 2003, NEUROLOGY, V60, P1899, DOI 10.1212/01.WNL.0000065916.25128.25
   Weydert CJ, 2010, NAT PROTOC, V5, P51, DOI 10.1038/nprot.2009.197
   Woodruff-Pak DS, 2002, CNS DRUG REV, V8, P405
   Xu ZQ, 2012, CELL BIOCHEM BIOPHYS, V62, P55, DOI 10.1007/s12013-011-9258-5
   Yancopoulos GD, 2000, NATURE, V407, P242, DOI 10.1038/35025215
   Yao J, 2012, ADV PHARMACOL, V64, P327, DOI 10.1016/B978-0-12-394816-8.00010-6
   Ye SM, 2005, P NATL ACAD SCI USA, V102, P18700, DOI 10.1073/pnas.0508693102
   Yokota T, 2012, FEBS LETT, V586, P4357, DOI 10.1016/j.febslet.2012.10.050
   YOUNKIN SG, 1995, ANN NEUROL, V37, P287, DOI 10.1002/ana.410370303
   Zhang Zhenxin, 2002, Zhonghua Yi Xue Za Zhi, V82, P941
   Zhao M, 2003, NEUROCHEM RES, V28, P307, DOI 10.1023/A:1022337519035
   Zhukareva V, 2002, AM J PATHOL, V161, P1135, DOI 10.1016/S0002-9440(10)64390-8
   Zuliani G, 2008, J NEUROL SCI, V272, P164, DOI 10.1016/j.jns.2008.05.020
NR 200
TC 43
Z9 44
U1 1
U2 21
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-4064
EI 1875-6638
J9 MED CHEM
JI Med. Chem.
PY 2016
VL 12
IS 3
BP 226
EP 237
DI 10.2174/1573406411666151030111820
PG 12
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DI7ML
UT WOS:000373684700005
PM 26527156
DA 2025-06-11
ER

PT J
AU Hart, R
   Doherty, DA
AF Hart, Roger
   Doherty, Dorota A.
TI The Potential Implications of a PCOS Diagnosis on a Woman's Long-Term
   Health Using Data Linkage
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID POLYCYSTIC-OVARY-SYNDROME; IMPAIRED GLUCOSE-TOLERANCE;
   INSULIN-RESISTANCE; DIABETES-MELLITUS; CARDIOVASCULAR-DISEASE;
   ENDOMETRIAL CANCER; METABOLIC SYNDROME; WESTERN-AUSTRALIA; WOMEN; RISK
AB Context: The polycystic ovary syndrome (PCOS) is the commonest endocrine abnormality in women of reproductive age.
   Objective: To determine the rate of hospital admissions for women with PCOS in Western Australian population in comparison to women without PCOS.
   Design: A population-based retrospective cohort study using data linkage in a statewide hospital morbidity database system.
   Setting: All hospitals within Western Australia.
   Participants: A total of 2566 women with PCOS hospitalized from 1997-2011 and 25 660 randomly selected age-matched women without a PCOS diagnosis derived from the electoral roll.
   Main Outcome Measures: Hospitalizations by ICD-10-M diagnoses from 15 years were compared.
   Results: Hospitalizations were followed until a median age of 35.8 years (interquartile range, 31.0-39.9). PCOS was associated with more nonobstetric and non-injury-related hospital admissions (median, 5 vs 2; P < .001), a diagnosis of adult-onset diabetes (12.5 vs 3.8%), obesity (16.0 vs 3.7%), hypertensive disorder (3.8 vs 0.7%), ischemic heart disease (0.8 vs 0.2%), cerebrovascular disease (0.6 vs 0.2%), arterial and venous disease (0.5 vs 0.2% and 10.4 vs 5.6%, respectively), asthma (10.6 vs 4.5%), stress/anxiety (14.0 vs 5.9%), depression (9.8 vs 4.3%), licit/illicit drug-related admissions (8.8 vs 4.5%), self-harm (7.2 vs 2.9%), land transport accidents (5.2 vs 3.8%), and mortality (0.7 vs 0.4%) (all P < .001). Women with PCOS had a higher rate of admissions for menorrhagia (14.1 vs 3.6%), treatment of infertility (40.9 vs 4.6%), and miscarriage (11.1 vs 6.1%) and were more likely to require in vitro fertilization (17.2 vs 2.0%).
   Conclusion: PCOS has profound medical implications for the health of women, and health care resources should be directed accordingly.
C1 [Hart, Roger; Doherty, Dorota A.] Univ Western Australia, Sch Womens & Infants Hlth, Perth, WA 6008, Australia.
   [Hart, Roger] Bethesda Hosp, Fertil Specialists Western Australia, Perth, WA 6010, Australia.
   [Doherty, Dorota A.] King Edward Mem Hosp, Women & Infants Res Fdn, Perth, WA 6008, Australia.
C3 University of Western Australia; Women & Infants Research Foundation;
   King Edward Memorial Hospital; University of Western Australia
RP Hart, R (corresponding author), Univ Western Australia, Sch Womens & Infants Hlth, King Edward Mem Hosp, 374 Bagot Rd, Subiaco, WA 6008, Australia.
EM roger.hart@uwa.edu.au
OI Hart, Roger/0000-0002-6610-3040
CR Agrawal R, 2004, FERTIL STERIL, V82, P1352, DOI 10.1016/j.fertnstert.2004.04.041
   [Anonymous], 1992, POLYCYSTIC OVARY SYN
   Azziz R, 2005, J CLIN ENDOCR METAB, V90, P4650, DOI 10.1210/jc.2005-0628
   Azziz R, 2004, REPROD BIOMED ONLINE, V8, P644, DOI 10.1016/S1472-6483(10)61644-6
   Baird DT, 2012, HUM REPROD UPDATE, V18, P586, DOI 10.1093/humupd/dms019
   Balen A, 2003, BEST PRACT RES CL OB, V17, P263, DOI 10.1016/S1521-6934(02)00119-0
   Bird ST, 2013, CAN MED ASSOC J, V185, pE115, DOI 10.1503/cmaj.120677
   Chang J, 2004, FERTIL STERIL, V81, P19, DOI 10.1016/j.fertnstert.2003.10.004
   Chittenden BG, 2009, REPROD BIOMED ONLINE, V19, P398, DOI 10.1016/S1472-6483(10)60175-7
   Clark A, 2010, AUST HEALTH REV, V34, P210, DOI 10.1071/AH09805
   Cussons AJ, 2006, ATHEROSCLEROSIS, V185, P227, DOI 10.1016/j.atherosclerosis.2005.10.007
   DAHLGREN E, 1992, FERTIL STERIL, V57, P505
   Dumesic DA, 2013, STEROIDS, V78, P782, DOI 10.1016/j.steroids.2013.04.004
   Ehrmann DA, 1999, DIABETES CARE, V22, P141, DOI 10.2337/diacare.22.1.141
   Elting MW, 2001, HUM REPROD, V16, P556, DOI 10.1093/humrep/16.3.556
   Fauser BCJM, 2012, FERTIL STERIL, V97, P28, DOI 10.1016/j.fertnstert.2011.09.024
   Fearnley EJ, 2010, CANCER CAUSE CONTROL, V21, P2303, DOI 10.1007/s10552-010-9658-7
   Haoula Z, 2012, HUM REPROD, V27, P1327, DOI 10.1093/humrep/des042
   Hart R, 2004, BEST PRACT RES CL OB, V18, P671, DOI 10.1016/j.bpobgyn.2004.05.001
   Hart R, 2007, CURR OPIN OBSTET GYN, V19, P529, DOI 10.1097/GCO.0b013e3282f10e22
   Hart R, 2006, BEST PRACT RES CL OB, V20, P751, DOI 10.1016/j.bpobgyn.2006.04.006
   Hennessy S, 1999, AM J EPIDEMIOL, V149, P195
   Hickey M, 2011, HUM REPROD, V26, P1469, DOI 10.1093/humrep/der102
   Holman CDJ, 1999, AUST NZ J PUBL HEAL, V23, P453, DOI 10.1111/j.1467-842X.1999.tb01297.x
   Ibáñez L, 2004, J PEDIATR-US, V144, P23, DOI 10.1016/j.jpeds.2003.08.015
   Jedel E, 2010, HUM REPROD, V25, P450, DOI 10.1093/humrep/dep384
   Joham AE, 2014, J CLIN ENDOCR METAB, V99, pE447, DOI 10.1210/jc.2013-2007
   Jones GL, 2008, HUM REPROD UPDATE, V14, P15
   Legro RS, 2013, J CLIN ENDOCR METAB, V98, P4565, DOI 10.1210/jc.2013-2350
   Legro RS, 1999, J CLIN ENDOCR METAB, V84, P165, DOI 10.1210/jc.84.1.165
   Li YA, 2011, FERTIL STERIL, V96, P452, DOI 10.1016/j.fertnstert.2011.05.072
   Mani H, 2013, CLIN ENDOCRINOL, V78, P926, DOI 10.1111/cen.12068
   Månsson M, 2008, PSYCHONEUROENDOCRINO, V33, P1132, DOI 10.1016/j.psyneuen.2008.06.003
   Meyer C, 2005, J CLIN ENDOCR METAB, V90, P4630, DOI 10.1210/jc.2004-1487
   Meyer C, 2007, DIABETES CARE, V30, P471, DOI 10.2337/dc06-0618
   Moran LJ, 2010, HUM REPROD UPDATE, V16, P347, DOI 10.1093/humupd/dmq001
   Morgan CL, 2012, J CLIN ENDOCR METAB, V97, P3251, DOI 10.1210/jc.2012-1690
   Norman RJ, 2001, HUM REPROD, V16, P1995, DOI 10.1093/humrep/16.9.1995
   Okoroh EM, 2012, AM J OBSTET GYNECOL, V207, DOI 10.1016/j.ajog.2012.08.007
   Stepto NK, 2013, HUM REPROD, V28, P777, DOI 10.1093/humrep/des463
   Teede HJ, 2006, ENDOCRINE, V30, P45, DOI 10.1385/ENDO:30:1:45
   Teede HJ, 2013, OBESITY, V21, P1526, DOI 10.1002/oby.20213
   Teede HJ, 2011, MED J AUSTRALIA, V195, pS69, DOI 10.5694/mja11.10915
   Trent Maria E, 2003, J Pediatr Adolesc Gynecol, V16, P33, DOI 10.1016/S1083-3188(02)00205-X
   Troisi R, 2003, INT J EPIDEMIOL, V32, P455, DOI 10.1093/ije/dyg094
   Veltman-Verhulst SM, 2012, HUM REPROD UPDATE, V18, P638, DOI 10.1093/humupd/dms029
   Wang J, 2013, AM J OBSTET GYNECOL, V209, DOI 10.1016/j.ajog.2013.05.007
   Wild RA, 2002, HUM REPROD UPDATE, V8, P231, DOI 10.1093/humupd/8.3.231
   Wild RA, 2010, J CLIN ENDOCR METAB, V95, P2038, DOI 10.1210/jc.2009-2724
   Yildiz BO, 2012, HUM REPROD, V27, P3067, DOI 10.1093/humrep/des232
NR 50
TC 273
Z9 294
U1 1
U2 23
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD MAR
PY 2015
VL 100
IS 3
BP 911
EP 919
DI 10.1210/jc.2014-3886
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CG5TR
UT WOS:000353358900039
PM 25532045
DA 2025-06-11
ER

PT J
AU Albu, A
   Para, I
   Porojan, M
AF Albu, Adriana
   Para, Ioana
   Porojan, Mihai
TI Uric Acid and Arterial Stiffness
SO THERAPEUTICS AND CLINICAL RISK MANAGEMENT
LA English
DT Review
DE uric acid; arterial stiffness; cardiovascular risk
ID XANTHINE-OXIDASE INHIBITION; MUSCLE-CELL-PROLIFERATION; CARDIAC-SURGERY
   PATIENTS; HIGH-DOSE ALLOPURINOL; PULSE-WAVE VELOCITY; VASCULAR INDEX
   CAVI; ALL-CAUSE MORTALITY; OXIDATIVE STRESS; BLOOD-PRESSURE; AORTIC
   STIFFNESS
AB Hyperuricemia is usually associated with hypertension, diabetes mellitus, metabolic syndrome and chronic kidney disease. Accumulating data from epidemiological studies indicate an association of increased uric acid (UA) with cardiovascular diseases. Possible pathogenic mechanisms include enhancement of oxidative stress and systemic inflammation caused by hyperuricemia. Arterial stiffness may be one of the possible pathways between hyperuricemia and cardiovascular disease, but a clear relationship between increased UA and vascular alterations has not been confirmed. The review summarizes the epidemiological studies investigating the relationship between UA and arterial stiffness and highlights the results of interventional studies evaluating arterial stiffness parameters in patients treated with UA-lowering drugs.
C1 [Albu, Adriana; Porojan, Mihai] Iuliu Hatieganu Univ Med & Pharm, Dept Internal Med 2, Cluj Napoca, Romania.
   [Para, Ioana] Iuliu Hatieganu Univ Med & Pharm, Dept Internal Med 4, 8 Babes St, Cluj Napoca 400012, Romania.
C3 Iuliu Hatieganu University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy
RP Para, I (corresponding author), Iuliu Hatieganu Univ Med & Pharm, Dept Internal Med 4, 8 Babes St, Cluj Napoca 400012, Romania.
EM ioana.para@yahoo.com
RI albu, adriana/D-4480-2016
CR Cipolli JAA, 2012, BMC CARDIOVASC DISOR, V12, DOI 10.1186/1471-2261-12-52
   Agarwal V, 2013, J CLIN HYPERTENS, V15, P435, DOI 10.1111/j.1751-7176.2012.00701.x
   Alem MM, 2018, CLIN MED INSIGHTS-CA, V12, DOI 10.1177/1179546818779584
   Alper AB, 2005, HYPERTENSION, V45, P34, DOI 10.1161/01.HYP.0000150783.79172.bb
   ARAI H, 1990, NATURE, V348, P730, DOI 10.1038/348730a0
   Aroor AR, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0750-8
   Aroor AR, 2017, METABOLISM, V74, P32, DOI 10.1016/j.metabol.2017.06.006
   Bae JS, 2013, ATHEROSCLEROSIS, V231, P145, DOI 10.1016/j.atherosclerosis.2013.08.017
   Baena CP, 2015, AM J HYPERTENS, V28, P966, DOI 10.1093/ajh/hpu298
   Bauer F, 2017, ANN TRANSPL, V22, P431, DOI 10.12659/AOT.901657
   BECKER BF, 1993, FREE RADICAL BIO MED, V14, P615, DOI 10.1016/0891-5849(93)90143-I
   Bekki M, 2019, CURR VASC PHARMACOL, V17, P411, DOI 10.2174/1570161116666180515154555
   Bellomo Gianni, 2015, World J Nephrol, V4, P324, DOI 10.5527/wjn.v4.i3.324
   Bian SY, 2012, IRAN J PUBLIC HEALTH, V41, P33
   BORDER WA, 1994, NEW ENGL J MED, V331, P1286
   Bredemeier M, 2018, BMC CARDIOVASC DISOR, V18, DOI 10.1186/s12872-018-0757-9
   Briet M, 2012, KIDNEY INT, V82, P388, DOI 10.1038/ki.2012.131
   Canepa M, 2017, HYPERTENSION, V69, P228, DOI 10.1161/HYPERTENSIONAHA.116.08114
   Cecelja M, 2009, HYPERTENSION, V54, P1328, DOI 10.1161/HYPERTENSIONAHA.109.137653
   Chaudhary K, 2013, CARDIORENAL MED, V3, P208, DOI 10.1159/000355405
   Chen X, 2010, AM J HYPERTENS, V23, P387, DOI 10.1038/ajh.2009.277
   Chilton R, 2015, DIABETES OBES METAB, V17, P1180, DOI 10.1111/dom.12572
   Choi HY, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0180406
   Choi YJ, 2014, FASEB J, V28, P3197, DOI 10.1096/fj.13-247148
   Chou P, 2001, J RHEUMATOL, V28, P571
   Cicero AFG, 2014, J HYPERTENS, V32, P57, DOI 10.1097/HJH.0b013e328365b916
   Corry DB, 2008, J HYPERTENS, V26, P269, DOI 10.1097/HJH.0b013e3282f240bf
   Cuenca JA, 2019, INT J RHEUMATOL, V2019, DOI 10.1155/2019/1076189
   Deng G, 2016, MED SCI MONITOR, V22, P1389, DOI 10.12659/MSM.898370
   Ding XH, 2017, SAUDI J BIOL SCI, V24, P574, DOI 10.1016/j.sjbs.2017.01.028
   Drüppel V, 2013, FASEB J, V27, P3652, DOI 10.1096/fj.13-228312
   du Plooy Christine Susara, 2015, J Amino Acids, V2015, P481517, DOI 10.1155/2015/481517
   El Ridi R, 2017, J ADV RES, V8, P487, DOI 10.1016/j.jare.2017.03.003
   Elsurer R, 2014, BLOOD PRESS MONIT, V19, P271, DOI 10.1097/MBP.0000000000000056
   Fang JI, 2014, ATHEROSCLEROSIS, V236, P389, DOI 10.1016/j.atherosclerosis.2014.07.024
   Feig DI, 2008, NEW ENGL J MED, V359, P1811, DOI 10.1056/NEJMra0800885
   Feig DI, 2006, CURR HYPERTENS REP, V8, P111, DOI 10.1007/s11906-006-0005-z
   Feig DI, 2003, HYPERTENSION, V42, P247, DOI 10.1161/01.HYP.0000085858.66548.59
   Frauchiger B, 2001, STROKE, V32, P836, DOI 10.1161/01.STR.32.4.836
   Fu SH, 2015, ANGIOLOGY, V66, P950, DOI 10.1177/0003319715573910
   George J, 2006, CIRCULATION, V114, P2508, DOI 10.1161/CIRCULATIONAHA.106.651117
   Gicquel T, 2015, FASEB J, V29, P4162, DOI 10.1096/fj.14-267393
   Glantzounis GK, 2005, CURR PHARM DESIGN, V11, P4145, DOI 10.2174/138161205774913255
   Gómez-Marcos MA, 2013, AM J HYPERTENS, V26, P599, DOI 10.1093/ajh/hps097
   Grimaldi-Bensouda L, 2015, ANN RHEUM DIS, V74, P836, DOI 10.1136/annrheumdis-2012-202972
   Heo SH, 2010, J NEUROL SCI, V297, P6, DOI 10.1016/j.jns.2010.07.007
   Higgins P, 2012, CARDIOVASC THER, V30, P217, DOI 10.1111/j.1755-5922.2011.00277.x
   Hoieggen A, 2004, KIDNEY INT, V65, P1041, DOI 10.1111/j.1523-1755.2004.00484.x
   Hsu PF, 2013, INT J CARDIOL, V168, P2057, DOI 10.1016/j.ijcard.2013.01.164
   Hwang J, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000012086
   Ishizaka N, 2007, ATHEROSCLEROSIS, V192, P131, DOI 10.1016/j.atherosclerosis.2006.04.016
   Izzo JL, 2000, BLOOD PRESS MONIT, V5, pS7, DOI 10.1097/00126097-200010002-00003
   Jin M, 2012, FRONT BIOSCI-LANDMRK, V17, P656, DOI 10.2741/3950
   Kamatani N, 2011, JCR-J CLIN RHEUMATOL, V17, pS13, DOI 10.1097/RHU.0b013e31821d36cc
   Kanbay M, 2007, INT UROL NEPHROL, V39, P1227, DOI 10.1007/s11255-007-9253-3
   Kanellis J, 2003, HYPERTENSION, V41, P1287, DOI 10.1161/01.HYP.0000072820.07472.3B
   Kang DH, 2005, J AM SOC NEPHROL, V16, P3553, DOI 10.1681/ASN.2005050572
   Kang DH, 2002, J AM SOC NEPHROL, V13, P2888, DOI 10.1097/01.ASN.0000034910.58454.FD
   Khan F, 2008, ATHEROSCLEROSIS, V200, P374, DOI 10.1016/j.atherosclerosis.2007.12.023
   Khosla UM, 2005, KIDNEY INT, V67, P1739, DOI 10.1111/j.1523-1755.2005.00273.x
   Kim SY, 2010, ARTHRIT CARE RES, V62, P170, DOI 10.1002/acr.20065
   Ko J, 2019, FASEB J, V33, P13334, DOI 10.1096/fj.201901148R
   Kodama S, 2009, DIABETES CARE, V32, P1737, DOI 10.2337/dc09-0288
   Kurra V, 2009, AM J HYPERTENS, V22, P964, DOI 10.1038/ajh.2009.109
   Kushiyama A, 2016, MEDIAT INFLAMM, V2016, DOI 10.1155/2016/8603164
   Kuwabara M, 2018, HYPERTENSION, V72, P582, DOI 10.1161/HYPERTENSIONAHA.118.11496
   Kuwabara M, 2018, HYPERTENSION, V71, P78, DOI 10.1161/HYPERTENSIONAHA.117.10370
   Kuwabara M, 2017, HYPERTENSION, V69, P1036, DOI [10.1161/HYPERTENSIONAHA.116.08998, 10.1161/hypertensionaha.116.08998]
   Kuwabara M, 2015, PULSE, V3, P242, DOI 10.1159/000443769
   Lastra G, 2017, AM J PHYSIOL-REG I, V313, pR67, DOI 10.1152/ajpregu.00483.2016
   Laurent S, 2006, EUR HEART J, V27, P2588, DOI 10.1093/eurheartj/ehl254
   Lee H, 2017, KOREAN J FAM MED, V38, P333, DOI 10.4082/kjfm.2017.38.6.333
   Li Y, 2014, ANGIOLOGY, V65, P634, DOI 10.1177/0003319713513143
   Liang J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051101
   Lim Ji Hyon, 2010, Korean Circ J, V40, P314, DOI 10.4070/kcj.2010.40.7.314
   Liu H, 2018, J ATHEROSCLER THROMB, V25, P254, DOI 10.5551/jat.39685
   Liu T, 2017, SIGNAL TRANSDUCT TAR, V2, DOI 10.1038/sigtrans.2017.23
   Liu XH, 2018, KIDNEY BLOOD PRESS R, V43, P1451, DOI 10.1159/000493659
   Luk AJ, 2009, RHEUMATOLOGY, V48, P804, DOI 10.1093/rheumatology/kep069
   Lv Q, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0056864
   MacIsaac RL, 2016, HYPERTENSION, V67, P535, DOI 10.1161/HYPERTENSIONAHA.115.06344
   Madero M, 2009, AM J KIDNEY DIS, V53, P796, DOI 10.1053/j.ajkd.2008.12.021
   Maiuolo J, 2016, INT J CARDIOL, V213, P8, DOI 10.1016/j.ijcard.2015.08.109
   Malik UZ, 2011, FREE RADICAL BIO MED, V51, P179, DOI 10.1016/j.freeradbiomed.2011.04.004
   Masuo K, 2003, HYPERTENSION, V42, P474, DOI 10.1161/01.HYP.0000091371.53502.D3
   Mazzali M, 2001, HYPERTENSION, V38, P1101, DOI 10.1161/hy1101.092839
   McDonagh EM, 2014, PHARMACOGENET GENOM, V24, P464, DOI 10.1097/FPC.0000000000000058
   Mehta T, 2015, AM J HYPERTENS, V28, P877, DOI 10.1093/ajh/hpu253
   Mellen PB, 2006, HYPERTENSION, V48, P1037, DOI 10.1161/01.HYP.0000249768.26560.66
   Mishima M, 2016, DRUG RES, V66, P270, DOI 10.1055/s-0035-1569405
   MORIWAKI Y, 1993, BIOCHIM BIOPHYS ACTA, V1164, P327, DOI 10.1016/0167-4838(93)90266-T
   Mulè G, 2014, NUTR METAB CARDIOVAS, V24, P744, DOI 10.1016/j.numecd.2014.01.014
   Nagano S, 2017, HYPERTENS RES, V40, P620, DOI 10.1038/hr.2017.10
   Nagayama D, 2015, ATHEROSCLEROSIS, V239, P163, DOI 10.1016/j.atherosclerosis.2015.01.011
   Nakanishi N, 2003, EUR J EPIDEMIOL, V18, P523, DOI 10.1023/A:1024600905574
   Nemcsik Janos, 2012, World J Nephrol, V1, P25, DOI 10.5527/wjn.v1.i1.25
   Netea MG, 1997, BLOOD, V89, P577, DOI 10.1182/blood.V89.2.577
   Ng KP, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0091961
   Niskanen LK, 2004, ARCH INTERN MED, V164, P1546, DOI 10.1001/archinte.164.14.1546
   Nomura J, 2014, SCI REP-UK, V4, DOI 10.1038/srep04554
   Pancholia AK, 2018, INDIAN HEART J, V70, P915, DOI 10.1016/j.ihj.2018.08.022
   Park JS, 2012, MATURITAS, V73, P344, DOI 10.1016/j.maturitas.2012.09.009
   Park S, 2012, YONSEI MED J, V53, P258, DOI 10.3349/ymj.2012.53.2.258
   Patterson RA, 2003, J LIPID RES, V44, P512, DOI 10.1194/jlr.M200407-JLR200
   Perlstein TS, 2006, HYPERTENSION, V48, P1031, DOI 10.1161/01.HYP.0000248752.08807.4c
   Rajendra NS, 2011, J AM COLL CARDIOL, V58, P820, DOI 10.1016/j.jacc.2010.12.052
   Ramírez AJ, 2018, CURR HYPERTENS REV, V14, P154, DOI 10.2174/1573402114666180413143312
   RAO GN, 1991, J BIOL CHEM, V266, P8604
   Rizzo M, 2014, CURR VASC PHARMACOL, V12, P572, DOI 10.2174/1570161111999131205160756
   Saladini F, 2016, J HYPERTENS, V34, pE208, DOI 10.1097/01.hjh.0000500451.48010.ec
   Sanchez RA, 2018, DIABETES, V67, DOI 10.2337/db18-1216-P
   Sánchez-Lozada LG, 2008, AM J PHYSIOL-RENAL, V295, pF1134, DOI 10.1152/ajprenal.00104.2008
   Sezai A, 2015, J CARDIOL, V66, P298, DOI 10.1016/j.jjcc.2014.12.017
   Sezai A, 2013, CIRC J, V77, P2043, DOI 10.1253/circj.CJ-13-0082
   Shin JY, 2012, VASC MED, V17, P37, DOI 10.1177/1358863X11434197
   Singh M, 2018, CURR DRUG SAF, V13, P84, DOI 10.2174/1574886313666180226103408
   Stehouwer CDA, 2008, DIABETOLOGIA, V51, P527, DOI 10.1007/s00125-007-0918-3
   Striepe K, 2017, CIRCULATION, V136, P1167, DOI 10.1161/CIRCULATIONAHA.117.029529
   Struthers AD, 2002, HEART, V87, P229, DOI 10.1136/heart.87.3.229
   Sugihara S, 2015, CIRC J, V79, P1125, DOI 10.1253/circj.CJ-14-1267
   Sull Jae Woong, 2017, [Biomedical Science Letters, 대한의생명과학회지], V23, P201, DOI 10.15616/BSL.2017.23.3.201
   Sun CK, 2013, INTEGR BLOOD PRESS C, V6, P27, DOI 10.2147/IBPC.S34423
   Sun N, 2013, CHINESE MED J-PEKING, V126, P3097, DOI 10.3760/cma.j.issn.0366-6999.20130215
   Sundström J, 2005, HYPERTENSION, V45, P28, DOI 10.1161/01.HYP.0000150784.92944.9a
   Suzuki T, 2007, NITRIC OXIDE-BIOL CH, V16, P266, DOI 10.1016/j.niox.2006.10.008
   Tanaka A, 2018, INT J CARDIOL, V272, P308, DOI 10.1016/j.ijcard.2018.06.017
   Tanindi A, 2015, ANATOL J CARDIOL, V15, P396, DOI 10.5152/akd.2014.5447
   Tausche AK, 2014, RHEUMATOL INT, V34, P101, DOI 10.1007/s00296-013-2857-2
   Tomiyama H, 2018, HYPERTENSION, V72, P739, DOI 10.1161/HYPERTENSIONAHA.118.11390
   Tsai WC, 2009, HEART VESSELS, V24, P371, DOI 10.1007/s00380-008-1127-9
   Tsioufis C, 2005, J HUM HYPERTENS, V19, P211, DOI 10.1038/sj.jhh.1001810
   Tsioufis C, 2011, J HUM HYPERTENS, V25, P554, DOI 10.1038/jhh.2010.98
   Tsushima Y, 2013, J BIOL CHEM, V288, P27138, DOI 10.1074/jbc.M113.485094
   Verdecchia P, 2000, HYPERTENSION, V36, P1072, DOI 10.1161/01.HYP.36.6.1072
   Vlachopoulos C, 2011, AM J HYPERTENS, V24, P33, DOI 10.1038/ajh.2010.111
   Vlachopoulos C, 2010, J AM COLL CARDIOL, V55, P1318, DOI 10.1016/j.jacc.2009.10.061
   Wang JG, 2001, HYPERTENSION, V37, P1069, DOI 10.1161/01.HYP.37.4.1069
   WANG JG, 2002, CARDIOVASC RES REP, V23, P393
   Wang MC, 2005, AM J KIDNEY DIS, V45, P494, DOI 10.1053/j.ajkd.2004.11.011
   Waring WS, 2007, DIABETOLOGIA, V50, P2572, DOI 10.1007/s00125-007-0817-7
   Waring WS, 2006, DIABETES, V55, P3127, DOI 10.2337/db06-0283
   Waring WS, 2003, CLIN SCI, V105, P425, DOI 10.1042/CS20030149
   Waring WS, 2001, J CARDIOVASC PHARM, V38, P365, DOI 10.1097/00005344-200109000-00005
   White WB, 2018, NEW ENGL J MED, V378, P1200, DOI 10.1056/NEJMoa1710895
   Wijnands JMA, 2015, J HYPERTENS, V33, P1642, DOI 10.1097/HJH.0000000000000593
   Xia X, 2014, AM J KIDNEY DIS, V64, P257, DOI 10.1053/j.ajkd.2013.08.027
   Xie H, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/214836
   Xu YL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0078206
   Yamanaka H, 2014, J CARDIOVASC MED, V15, P364, DOI 10.2459/JCM.0b013e328360940b
   Zhang J, 2014, J ENDOCRINOL INVEST, V37, P441, DOI 10.1007/s40618-013-0034-9
   Zhang T, 2017, RHEUMATOLOGY, V56, P1144, DOI 10.1093/rheumatology/kex065
   Zharikov S, 2008, AM J PHYSIOL-CELL PH, V295, pC1183, DOI 10.1152/ajpcell.00075.2008
   Zheng XY, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0712-x
   Zieman SJ, 2005, ARTERIOSCL THROM VAS, V25, P932, DOI 10.1161/01.ATV.0000160548.78317.29
NR 154
TC 38
Z9 40
U1 3
U2 17
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-203X
J9 THER CLIN RISK MANAG
JI Therap. Clin. Risk Manag.
PY 2020
VL 16
BP 39
EP 54
DI 10.2147/TCRM.S232033
PG 16
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA KH6AG
UT WOS:000510731700001
PM 32095074
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Na, HJ
   Sung, MJ
   Park, JS
AF Na, Hyun-Jin
   Sung, Mi-Jeong
   Park, Joung-Sun
TI Age- and oxidative stress-induced centrosome amplification and renal
   stones in Drosophila Malpighian tubules
SO BIOLOGY OPEN
LA English
DT Article
DE Drosophila; Aging; Malpighian tubules; Centrosome amplification; Renal
   stone; Aging marker
ID METABOLIC SYNDROME; KIDNEY-STONE; STEM-CELLS; DEFICIENCY; COMPONENTS;
   METFORMIN
AB Renal diseases, including cancer, are rapidly increasing worldwide, driven by rising temperatures and changing diets, especially among younger people. Renal stones, a major risk for chronic renal disease, are increasingly common due to various health issues. Research on the underlying mechanisms, drug discovery, and the effects of aging and stress is limited. We used Drosophila, due to its similarity to the human renal system and ease of use, to identify cancer hallmarks and renal stone formation related to aging and oxidative stress. Our results indicate that centrosome amplification and stone formation increase with age and oxidative stress, and high sucrose feeding also heightens stone formation in the renal system. Our results show a close relationship between these diseases and aging, reactive oxygen species (ROS) stress, and chronic diseases. We suggest that the Drosophila renal model could be a powerful tool to study the relationship between age and age-related diseases and to discovering new agents for nephropathy.
C1 [Na, Hyun-Jin; Sung, Mi-Jeong] Korea Food Res Inst, Div Food Funct Res, Aging & Metab Res Grp, Wanju 55365, South Korea.
   [Park, Joung-Sun] Pusan Natl Univ, Inst Nanobio Convergence, Busan 46241, South Korea.
   [Park, Joung-Sun] Pusan Natl Univ, Dept Mol Biol, Busan 46241, South Korea.
C3 Korea Food Research Institute (KFRI); Pusan National University; Pusan
   National University
RP Park, JS (corresponding author), Pusan Natl Univ, Inst Nanobio Convergence, Busan 46241, South Korea.; Park, JS (corresponding author), Pusan Natl Univ, Dept Mol Biol, Busan 46241, South Korea.
EM dreamjs78@pusan.ac.kr
FU Main Research Program of the Korea Food Research Institute; Basic
   Science Research Program through the National Research Foundation of
   Korea (NRF) - Ministry of Education [RS-2023-00243729]; Pusan National
   University;  [E0210102]
FX This study was supported by the Main Research Program (E0210102) of the
   Korea Food Research Institute. This research was supported by the Basic
   Science Research Program through the National Research Foundation of
   Korea (NRF) , funded by the Ministry of Education (RS-2023-00243729) .
   Open Access funding provided by Pusan National University. Deposited in
   PMC for immediate release.
CR Abufaraj M, 2021, EUR UROL FOCUS, V7, P1468, DOI 10.1016/j.euf.2020.08.011
   Alelign T, 2018, ADV UROL, V2018, DOI 10.1155/2018/3068365
   Ali SN, 2018, DIS MODEL MECH, V11, DOI 10.1242/dmm.035873
   Boyd C, 2018, ASIAN J UROL, V5, P215, DOI 10.1016/j.ajur.2018.06.002
   Chi T, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0124150
   Chou YH, 2011, KAOHSIUNG J MED SCI, V27, P264, DOI 10.1016/j.kjms.2010.11.008
   Cohen E, 2020, GENETICS, V214, P235, DOI 10.1534/genetics.119.302289
   Dow JAT, 2010, AM J PHYSIOL-RENAL, V299, pF1237, DOI 10.1152/ajprenal.00521.2010
   Garaycoechea JI, 2023, NAT REV NEPHROL, V19, P229, DOI 10.1038/s41581-022-00671-z
   Guo J, 2022, SIGNAL TRANSDUCT TAR, V7, DOI 10.1038/s41392-022-01251-0
   Herranz H, 2017, J DEV BIOL, V5, DOI 10.3390/jdb5040015
   Khan SR, 1997, WORLD J UROL, V15, P236, DOI 10.1007/BF01367661
   Kwok SH, 2024, bioRxiv, DOI [10.1101/2024.03.21.586173, 10.1101/2024.03.21.586173, DOI 10.1101/2024.03.21.586173]
   Lee YC, 2016, AGING MALE, V19, P197, DOI 10.1080/13685538.2016.1174987
   May CE, 2019, CELL REP, V27, P1675, DOI 10.1016/j.celrep.2019.04.027
   McNeely T, 2020, HUM GENET, V139, P309, DOI 10.1007/s00439-019-02047-z
   Mirzoyan Z, 2019, FRONT GENET, V10, DOI 10.3389/fgene.2019.00051
   Na HJ, 2018, BIOCHEM BIOPH RES CO, V498, P18, DOI 10.1016/j.bbrc.2018.02.191
   Na HJ, 2015, MECH AGEING DEV, V149, P8, DOI 10.1016/j.mad.2015.05.004
   Park JS, 2024, AGING-US, V16, P2005, DOI 10.18632/aging.205518
   Park JS, 2018, AGING-US, V10, P322, DOI 10.18632/aging.101390
   Park JS, 2014, BIOCHEM BIOPH RES CO, V450, P961, DOI 10.1016/j.bbrc.2014.06.085
   Shen SL, 2023, J TRANSL MED, V21, DOI 10.1186/s12967-023-04356-4
   Ushimoto C, 2023, FREE RADICAL BIO MED, V207, P120, DOI 10.1016/j.freeradbiomed.2023.07.013
   Wang CH, 2020, ELIFE, V9, DOI 10.7554/eLife.54096
   Wang SY, 2022, HELIYON, V8, DOI 10.1016/j.heliyon.2022.e09232
   Wang S, 2020, INT BRAZ J UROL, V46, P70, DOI [10.1590/s1677-5538.ibju.2019.0278, 10.1590/S1677-5538.IBJU.2019.0278]
   Xu ZZ, 2023, FRONT IMMUNOL, V14, DOI 10.3389/fimmu.2023.1142207
   Ye ZY, 2023, AGING MALE, V26, DOI 10.1080/13685538.2023.2195932
   Yuan Q, 2022, SIGNAL TRANSDUCT TAR, V7, DOI 10.1038/s41392-022-01036-5
NR 30
TC 1
Z9 1
U1 0
U2 0
PU COMPANY BIOLOGISTS LTD
PI CAMBRIDGE
PA BIDDER BUILDING, STATION RD, HISTON, CAMBRIDGE CB24 9LF, ENGLAND
SN 2046-6390
J9 BIOL OPEN
JI Biol. Open
PD DEC
PY 2024
VL 13
IS 12
AR bio061743
DI 10.1242/bio.061743
PG 6
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA R2A9Z
UT WOS:001389555700001
PM 39680672
OA gold
DA 2025-06-11
ER

PT J
AU Li, LL
   Guo, ZL
   Zhao, Y
   Liang, CJ
   Zheng, WX
   Tian, WX
   Chen, YL
   Cheng, Y
   Zhu, FW
   Xiang, XX
AF Li, Lanlan
   Guo, Zhiliang
   Zhao, Yi
   Liang, Chuanjie
   Zheng, Wenxiang
   Tian, Wenxiu
   Chen, Yalin
   Cheng, Yi
   Zhu, Fengwen
   Xiang, Xinxin
TI The impact of oxidative stress on abnormal lipid metabolism-mediated
   disease development
SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Review
DE Oxidative stress; Abnormal lipid metabolism; Metabolic syndrome;
   Inflammation; Reactive oxygen species
ID FATTY LIVER-DISEASE; ATHEROSCLEROTIC CARDIOVASCULAR-DISEASE; PRIMARY
   PREVENTION; 2024 GUIDELINES; TAIWAN SOCIETY; OBESE MICE; HYPERTENSION;
   ACTIVATION; BIOMARKERS; CARDIOLOGY
AB Oxidative stress arises from an imbalance between cellular oxidation and anti-oxidation mechanisms, leading to various harmful effects on physiological health. These include inflammatory neutrophil infiltration, increased secretion of proteases, and increased production of oxidative intermediates, all of which significantly contribute to aging and the onset of multiple diseases. This review explores abnormal lipid metabolism, characterized by dysregulation in lipid synthesis, catabolism, digestion, absorption, and transport, with the potential to lead to lipid droplet accumulation or deficit across tissues, thus causing adverse health outcomes. Importantly, the intricate relationship between oxidative stress and inflammation plays a central role in exacerbating metabolic disorders, including diabetes, obesity, hypertension, non-alcoholic fatty liver disease, atherosclerosis, and lung fibrosis. This review seeks to compile and integrate recent research findings on the influence of oxidative stress on abnormal lipid metabolism pathology. A deeper understanding of this connection could reveal new perspectives for advancing the treatment and management of metabolic disorders.
C1 [Li, Lanlan; Liang, Chuanjie; Zheng, Wenxiang; Tian, Wenxiu; Chen, Yalin; Cheng, Yi; Zhu, Fengwen; Xiang, Xinxin] Zibo Cent Hosp, Ctr Translat Med, Zibo 255000, Shandong, Peoples R China.
   [Guo, Zhiliang] 80th Grp Army Hosp Chinese PLA, Weifang 261021, Shandong, Peoples R China.
   [Zhao, Yi] Shandongs First Med Univ, Shandong Prov Hosp, Jinan, Shandong, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical Sciences
RP Zhu, FW; Xiang, XX (corresponding author), Zibo Cent Hosp, Ctr Translat Med, Zibo 255000, Shandong, Peoples R China.
EM 389860168@qq.com; xiangxinxin@bjmu.edu.cn
FU Natural Science Foundation of Shandong Province [ZR2024MH344,
   ZR2020MC062]; National Natural Sciences Foundation of China [81600695];
   Key Research and Development Project of Shandong Province program
   [2019GSF108269]
FX This work was supported by the Natural Science Foundation of Shandong
   Province (No. ZR2024MH344 and ZR2020MC062) , National Natural Sciences
   Foundation of China (No.81600695) , the Key Research and Development
   Project of Shandong Province program (No. 2019GSF108269) .
CR Abd El-Aziz R, 2020, CLIN EXP HEPATOL, V6, P28, DOI 10.5114/ceh.2020.93053
   Bai Y, 2021, BIOORG MED CHEM LETT, V48, DOI 10.1016/j.bmcl.2021.128238
   Benjamin EJ, 2018, CIRCULATION, V137, pE67, DOI [10.1161/CIR.0000000000000485, 10.1161/CIR.0000000000000558, 10.1161/CIR.0000000000000530]
   Bhatti J.S., BIOCH BIOPHYS ACTA B, V2017, P1066
   Biao YN, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.877924
   Buzzetti E, 2016, METABOLISM, V65, P1038, DOI 10.1016/j.metabol.2015.12.012
   Cai YC, 2025, PHYTOTHER RES, V39, P999, DOI 10.1002/ptr.8416
   Cappellari GG, 2022, METABOLISM, V133, DOI 10.1016/j.metabol.2022.155242
   Chakraborty S, 2020, HYPERTENSION, V75, P1386, DOI [10.1161/HYPERTENSIONAHA.120.13896.), 10.1161/HYPERTENSIONAHA.120.13896]
   Chan DC, 2020, ANNU REV PATHOL-MECH, V15, P235, DOI 10.1146/annurev-pathmechdis-012419-032711
   Chang SW, 2024, RES SPORTS MED, V32, P871, DOI 10.1080/15438627.2024.2349521
   Chao TH, 2024, ACTA CARDIOL SIN, V40, P669, DOI 10.6515/ACS.202411_40(6).20240724B
   Chao TH, 2024, ACTA CARDIOL SIN, V40, P479, DOI 10.6515/ACS.202409_40(5).20240724A
   Chaudhary K, 2011, CURR DIABETES REP, V11, P41, DOI 10.1007/s11892-010-0155-x
   Chen SS, 2024, BIOMED PHARMACOTHER, V178, DOI 10.1016/j.biopha.2024.117084
   Chen ZP, 2022, BMC COMPLEMENT MED, V22, DOI 10.1186/s12906-022-03658-2
   Cheng JJ, 2022, BIOMED PHARMACOTHER, V153, DOI 10.1016/j.biopha.2022.113335
   Cheng W, 2024, SCI TOTAL ENVIRON, V906, DOI 10.1016/j.scitotenv.2023.167529
   Dahl K, 2021, DIABETES OBES METAB, V23, P1594, DOI 10.1111/dom.14373
   de Lima RP, 2021, BRAZ J MED BIOL RES, V54, DOI [10.1590/1414-431X2021e11391, 10.1590/1414-431x2021e11391]
   Garcia D, 2017, MOL CELL, V66, P789, DOI 10.1016/j.molcel.2017.05.032
   Gawrieh S, 2012, DIGEST DIS SCI, V57, P952, DOI 10.1007/s10620-011-1994-2
   González P, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24119352
   Guo TW, 2023, BMC COMPLEMENT MED, V23, DOI 10.1186/s12906-023-04114-5
   Guo X, 2022, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.812166
   Huang LS, 2017, FREE RADICAL BIO MED, V112, P162, DOI 10.1016/j.freeradbiomed.2017.07.023
   Huang SH, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201800955
   García-Martínez BI, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24087422
   Jiang H, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/6061197
   Jiang S, 2025, FREE RADICAL BIO MED, V227, P472, DOI 10.1016/j.freeradbiomed.2024.12.005
   Jiang XJ, 2021, NAT REV MOL CELL BIO, V22, P266, DOI 10.1038/s41580-020-00324-8
   Jiang Z, 2011, FREE RADICAL BIO MED, V50, P907, DOI 10.1016/j.freeradbiomed.2011.01.011
   Jiang ZQ, 2024, TOXICOL SCI, V204, P57, DOI 10.1093/toxsci/kfae160
   Krsková K, 2025, J PHYSIOL BIOCHEM, V81, P137, DOI 10.1007/s13105-024-01060-9
   Laranjo Liliana, 2024, Glob Heart, V19, P8, DOI 10.5334/gh.1278
   Laurent S, 2012, LANCET, V380, P591, DOI 10.1016/S0140-6736(12)60825-3
   Li RR, 2022, J TRANSL MED, V20, DOI 10.1186/s12967-022-03540-2
   Li SM, 2022, J NAT MED-TOKYO, V76, P765, DOI 10.1007/s11418-022-01626-1
   Li XW, 2020, BRIT J PHARMACOL, V177, P3591, DOI 10.1111/bph.15083
   Li XS, 2022, ACTA PHARM SIN B, V12, P2280, DOI 10.1016/j.apsb.2021.12.014
   Li Z, 2020, PHYTOMEDICINE, V69, DOI 10.1016/j.phymed.2020.153209
   Liesa M, 2013, CELL METAB, V17, P491, DOI 10.1016/j.cmet.2013.03.002
   Lin FK, 2022, J EXP CLIN CANC RES, V41, DOI 10.1186/s13046-022-02315-3
   Liou SH, 2017, J HAZARD MATER, V331, P329, DOI 10.1016/j.jhazmat.2017.02.042
   Liu H, 2022, KIDNEY BLOOD PRESS R, V47, P423, DOI 10.1159/000524172
   Liu J, 2020, FOOD FUNCT, V11, P2535, DOI [10.1039/C9FO03028J, 10.1039/c9fo03028j]
   Liu J, 2025, INT IMMUNOPHARMACOL, V144, DOI 10.1016/j.intimp.2024.113707
   Lobo MD, 2017, EUR HEART J, V38, P1101, DOI 10.1093/eurheartj/ehw303
   Lolescu BA, 2025, MOL CELL BIOCHEM, V480, P2863, DOI 10.1007/s11010-024-05165-z
   Loomba R, 2013, NAT REV GASTRO HEPAT, V10, P686, DOI 10.1038/nrgastro.2013.171
   Lou BW, 2020, REDOX BIOL, V37, DOI 10.1016/j.redox.2020.101723
   Lu MC, 2016, SCI REP-UK, V6, DOI 10.1038/srep26585
   Luo J., 2024, Antioxidants, V13
   Luo XJ, 2017, MOL CANCER, V16, DOI 10.1186/s12943-017-0646-3
   Ma MH, 2023, J HAZARD MATER, V452, DOI 10.1016/j.jhazmat.2023.131217
   Mallard AR, 2020, REDOX REP, V25, P64, DOI 10.1080/13510002.2020.1795587
   Mone P, 2022, HYPERTENSION, V79
   Mooli RGR, 2022, COMPR PHYSIOL, V12, P3167, DOI 10.1002/cphy.c200021
   Mousa A.M., 2024, Tissue Cell, V93
   Muoio DM, 2012, CELL METAB, V15, P595, DOI 10.1016/j.cmet.2012.04.010
   Muro P, 2024, FRONT ENDOCRINOL, V15, DOI 10.3389/fendo.2024.1390351
   Odegaard AO, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-016-0369-6
   PANIKER NV, 1970, BIOCHIM BIOPHYS ACTA, V215, P456, DOI 10.1016/0304-4165(70)90096-6
   Paris S., 2024, Gastroenterology
   Peng Y., 2024, Toxicol. Appl. Pharmacol.
   Rezanka T, 2023, PROG LIPID RES, V91, DOI 10.1016/j.plipres.2023.101237
   Rinella ME, 2015, JAMA-J AM MED ASSOC, V313, P2263, DOI 10.1001/jama.2015.5370
   Sankaralingam S, 2024, FRONT IMMUNOL, V15, DOI 10.3389/fimmu.2024.1422095
   Sapra A., 2025, StatPearls Internet
   Sato I, 2022, PHARMACOL REP, V74, P669, DOI 10.1007/s43440-022-00380-1
   Seo E, 2019, AGING CELL, V18, DOI 10.1111/acel.12895
   Shi Jing Hui, 2025, Crit Rev Eukaryot Gene Expr, V35, P85, DOI 10.1615/CritRevEukaryotGeneExpr.2025057309
   Slimen IB, 2014, INT J HYPERTHER, V30, P513, DOI 10.3109/02656736.2014.971446
   Song CY, 2022, AQUACULTURE, V547, DOI 10.1016/j.aquaculture.2021.737441
   Song ZZ, 2020, CHEMOSPHERE, V246, DOI 10.1016/j.chemosphere.2019.125727
   Stamerra CA, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/9530007
   Tang YY, 2025, PLANT FOOD HUM NUTR, V80, DOI 10.1007/s11130-024-01249-9
   Thomas D, 2024, REDOX BIOL, V76, DOI 10.1016/j.redox.2024.103329
   Tratensek A, 2024, REDOX BIOL, V77, DOI 10.1016/j.redox.2024.103380
   Vanni E, 2010, DIGEST LIVER DIS, V42, P320, DOI 10.1016/j.dld.2010.01.016
   Veith C, 2019, ANTIOXID REDOX SIGN, V31, P1092, DOI 10.1089/ars.2019.7742
   Vinothiya K, 2017, BIOMED PHARMACOTHER, V87, P640, DOI 10.1016/j.biopha.2016.12.134
   Wang N, 2024, ANTIOXIDANTS-BASEL, V13, DOI 10.3390/antiox13040455
   Wang PF, 2022, MEDIAT INFLAMM, V2022, DOI 10.1155/2022/6394199
   Wang YG, 2024, J ETHNOPHARMACOL, V325, DOI 10.1016/j.jep.2024.117820
   Wei K, 2022, FOOD FUNCT, V13, P5782, DOI [10.1039/d2fo00199c, 10.1039/D2FO00199C]
   Wen L, 2022, FRONT BIOENG BIOTECH, V10, DOI 10.3389/fbioe.2022.912178
   Wu BA, 2022, NUTR RES, V105, P20, DOI 10.1016/j.nutres.2022.04.004
   Wu J, 2021, CELL DEATH DISCOV, V7, DOI 10.1038/s41420-021-00660-4
   Wu L., 2022, Oxid. Med. Cell. Longev., V2022, P1
   Wu ZH, 2020, FOOD FUNCT, V11, P799, DOI [10.1039/C9FO02262G, 10.1039/c9fo02262g]
   Wulff AB, 2023, DAN MED J, V70
   Xie LR, 2022, NUTRIENTS, V14, DOI 10.3390/nu14122473
   Xie WX, 2024, J AGR FOOD CHEM, V72, P27737, DOI 10.1021/acs.jafc.4c04887
   Xu BH, 2021, FRONT CELL DEV BIOL, V9, DOI 10.3389/fcell.2021.631413
   Xu WL, 2021, ANNU REV PHYSIOL, V83, P551, DOI 10.1146/annurev-physiol-031620-123956
   Yang ZJ, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.921255
   Zhang BH, 2022, FRONT MOL BIOSCI, V9, DOI 10.3389/fmolb.2022.909151
   Zhang H, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9111660
   Zhang JK, 2022, FOOD RES INT, V156, DOI 10.1016/j.foodres.2022.111196
   Zhang SH, 2022, REDOX BIOL, V54, DOI 10.1016/j.redox.2022.102390
   Zhang Y, 2022, J TRANSL MED, V20, DOI 10.1186/s12967-022-03408-5
   Zhao A, 2024, AM J REPROD IMMUNOL, V92, DOI 10.1111/aji.70017
   Zhao GS, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.857879
   Zhao MY, 2021, PHARMACOL RES, V166, DOI 10.1016/j.phrs.2021.105517
   Zhong YJ, 2022, FOOD CHEM TOXICOL, V159, DOI 10.1016/j.fct.2021.112697
   Zhu HZ, 2022, PHYTOMEDICINE, V104, DOI 10.1016/j.phymed.2022.154283
   Zhu S., 2024, Sci. Total Environ., V958
NR 108
TC 1
Z9 1
U1 10
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-9861
EI 1096-0384
J9 ARCH BIOCHEM BIOPHYS
JI Arch. Biochem. Biophys.
PD APR
PY 2025
VL 766
AR 110348
DI 10.1016/j.abb.2025.110348
EA FEB 2025
PG 9
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA Y2C5Z
UT WOS:001430272900001
PM 39961502
DA 2025-06-11
ER

PT J
AU Carro, N
   D'Adamo, P
   Lozada, M
AF Carro, N.
   D'Adamo, P.
   Lozada, M.
TI A School Intervention Helps Decrease Daily Stress While Enhancing Social
   Integration in Children
SO BEHAVIORAL MEDICINE
LA English
DT Article
DE Behavioral intervention; children stress; prevention; salivary cortisol;
   social integration
ID PROSOCIAL BEHAVIOR; METABOLIC SYNDROME; SALIVARY CORTISOL; PHYSICAL
   HEALTH; RESILIENCE; FRIENDSHIP; RESPONSES; SYMPTOMS; BRAIN
AB Stress coping is highly relevant during childhood. This study analyses how the participation in a behavioral intervention involving mindfulness-based practices and empathic collaboration activities impact on diurnal cortisol rhythm and social integration in children. In both experimental and waitlist groups, we evaluated before and after the intervention: daily stress, by sampling salivary cortisol at three measurement time-points, and social integration, assessed by a social preference index. Daily average cortisol (DAC) and the area under the curve (AUC) differed when comparing pre-post intervention values in both groups: in the experimental group these measures decreased while in the waitlist group DAC and AUC increased. At the end of the intervention, the experimental group showed an enhancement in the social preference index whereas this parameter diminished in the waitlist group. This kind of behavioral intervention seems to be effective at reducing daily stress and improving social integration in Primary School children.
C1 [Carro, N.; Lozada, M.] Natl Univ Comahue, INIBIOMA CONICET, San Carlos De Bariloche, Rio Negro, Argentina.
   [D'Adamo, P.] Natl Univ Comahue, IPEHCS, CONICET, Av de Los Pioneros 2350, RA-8400 San Carlos De Bariloche, Rio Negro, Argentina.
C3 Universidad Nacional del Comahue; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Universidad Nacional del Comahue
RP D'Adamo, P (corresponding author), Natl Univ Comahue, IPEHCS, CONICET, Av de Los Pioneros 2350, RA-8400 San Carlos De Bariloche, Rio Negro, Argentina.
EM paodadamo@gmail.com
FU National University of Comahue; National Council of Scientific and
   Technological Research of Argentina (CONICET)
FX This work was supported in part by the National University of Comahue
   and National Council of Scientific and Technological Research of
   Argentina (CONICET).
CR Adam EK, 2017, PSYCHONEUROENDOCRINO, V83, P25, DOI 10.1016/j.psyneuen.2017.05.018
   Ali A, 2017, J PEDIATR-US, V183, P184, DOI 10.1016/j.jpeds.2016.12.053
   Anagnostis P, 2009, J CLIN ENDOCR METAB, V94, P2692, DOI 10.1210/jc.2009-0370
   Fuentes MA, 2018, COMPLEXITY, DOI 10.1155/2018/3963061
   Author, 2018, TRANSYLV REV, V26, P1
   Bai S, 2017, PSYCHONEUROENDOCRINO, V83, P150, DOI 10.1016/j.psyneuen.2017.05.027
   Becker AE, 2011, BRIT J PSYCHIAT, V198, P43, DOI 10.1192/bjp.bp.110.078675
   Bornemann B, 2015, FRONT PSYCHOL, V5, DOI 10.3389/fpsyg.2014.01504
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   Chin B, 2018, PSYCHONEUROENDOCRINO, V90, P102, DOI 10.1016/j.psyneuen.2018.02.008
   CHROUSOS GP, 1992, JAMA-J AM MED ASSOC, V267, P1244, DOI 10.1001/jama.267.9.1244
   Cillessen A., 2009, HDB PEER INTERACTION, P82, DOI DOI 10.4135/9781412958479.N521
   Cohen S, 2003, PSYCHOSOM MED, V65, P652, DOI 10.1097/01.PSY.0000077508.57784.DA
   Cohen S, 2009, PERSPECT PSYCHOL SCI, V4, P375, DOI 10.1111/j.1745-6924.2009.01141.x
   Dekker MJHJ, 2008, J CLIN ENDOCR METAB, V93, P3741, DOI 10.1210/jc.2008-0496
   Ernst J, 2013, HUM BRAIN MAPP, V34, P1615, DOI 10.1002/hbm.22014
   Farb N, 2015, FRONT PSYCHOL, V6, DOI 10.3389/fpsyg.2015.00763
   Ferri F, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0075758
   Flook L, 2015, DEV PSYCHOL, V51, P44, DOI 10.1037/a0038256
   Fukushima H, 2011, INT J PSYCHOPHYSIOL, V79, P259, DOI 10.1016/j.ijpsycho.2010.10.015
   Garaigordobil Maite., 2005, PROGRAMA JUEGO 6 8 A
   Garland Eric L, 2017, Chronic Stress (Thousand Oaks), V1, DOI 10.1177/2470547017711912
   Grynberg D, 2015, PHYSIOL BEHAV, V140, P54, DOI 10.1016/j.physbeh.2014.12.026
   Hamer M, 2009, PEDIATRICS, V123, P1263, DOI 10.1542/peds.2008-1523
   Hesketh T, 2010, ARCH DIS CHILD, V95, P136, DOI 10.1136/adc.2009.171660
   KALFUS GR, 1985, J CLIN CHILD PSYCHOL, V14, P345, DOI 10.1207/s15374424jccp1404_13
   Kornienko O, 2016, HORM BEHAV, V80, P92, DOI 10.1016/j.yhbeh.2016.01.013
   Kornienko O, 2013, SOC NEUROSCI-UK, V8, P385, DOI 10.1080/17470919.2013.795500
   Lozada M, 2014, J MORAL EDUC, V43, P75, DOI 10.1080/03057240.2013.878244
   Lozada M, 2014, J DEV BEHAV PEDIATR, V35, P144, DOI 10.1097/DBP.0000000000000026
   Lupien SJ, 2007, BRAIN COGNITION, V65, P209, DOI 10.1016/j.bandc.2007.02.007
   Martín E, 2011, SPAN J PSYCHOL, V14, P88, DOI 10.5209/rev_SJOP.2011.v14.n1.7
   McEwen BS, 2016, ANN NY ACAD SCI, V1373, P56, DOI 10.1111/nyas.13020
   Meiklejohn J, 2012, MINDFULNESS, V3, P291, DOI 10.1007/s12671-012-0094-5
   Perez J.I., 2011, SUMMA PSICOLOGICA, V8, P5, DOI DOI 10.18774/448x.2011.8.83
   Perry-Parrish C, 2016, CURR PROB PEDIATR AD, V46, P172, DOI 10.1016/j.cppeds.2015.12.006
   Peters E, 2011, CHILD DEV, V82, P1906, DOI 10.1111/j.1467-8624.2011.01647.x
   Ponzi D, 2016, SOC NEUROSCI-UK, V11, P164, DOI 10.1080/17470919.2015.1045988
   Pruessner JC, 2003, PSYCHONEUROENDOCRINO, V28, P916, DOI 10.1016/S0306-4530(02)00108-7
   Pruessner JC, 1997, LIFE SCI, V61, P2539, DOI 10.1016/S0024-3205(97)01008-4
   Raposa EB, 2016, CLIN PSYCHOL SCI, V4, P691, DOI 10.1177/2167702615611073
   Sapolsky RM, 2000, ENDOCR REV, V21, P55, DOI 10.1210/er.21.1.55
   Schonert-Reichl KA, 2015, DEV PSYCHOL, V51, P52, DOI 10.1037/a0038454
   Shankar A, 2011, HEALTH PSYCHOL, V30, P377, DOI 10.1037/a0022826
   Sibinga Erica M S, 2016, Pediatrics, V137, DOI 10.1542/peds.2015-2532
   Spray J, 2018, HOMO, V69, P50, DOI 10.1016/j.jchb.2018.03.005
   Trianes M.V., 2002, ESTRES INFANCIA
   van der Wal MF, 2003, PEDIATRICS, V111, P1312, DOI 10.1542/peds.111.6.1312
   Vanaelst B, 2012, EUR CHILD ADOLES PSY, V21, P253, DOI 10.1007/s00787-012-0258-9
   Vliegenthart J, 2016, PSYCHONEUROENDOCRINO, V65, P9, DOI 10.1016/j.psyneuen.2015.11.022
NR 50
TC 7
Z9 7
U1 1
U2 16
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0896-4289
EI 1940-4026
J9 BEHAV MED
JI Behav. Med.
PD JUL 3
PY 2021
VL 47
IS 3
BP 251
EP 258
DI 10.1080/08964289.2020.1738319
EA MAR 2020
PG 8
WC Behavioral Sciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Psychiatry
GA TK9LM
UT WOS:000526498600001
PM 32275198
DA 2025-06-11
ER

PT J
AU Welch, G
   Wesolowski, C
   Zagarins, S
   Kuhn, J
   Romanelli, J
   Garb, J
   Allen, N
AF Welch, Garry
   Wesolowski, Cheryl
   Zagarins, Sofija
   Kuhn, Jay
   Romanelli, John
   Garb, Jane
   Allen, Nancy
TI Evaluation of Clinical Outcomes for Gastric Bypass Surgery: Results from
   a Comprehensive Follow-up Study
SO OBESITY SURGERY
LA English
DT Article
DE RYGB; Weight loss; %EWL; Bariatric surgery; Metabolic syndrome;
   Psychosocial adjustment; Self-management behaviors
ID PREDICTS WEIGHT-LOSS; PHYSICAL-ACTIVITY; BARIATRIC SURGERY;
   MORBID-OBESITY; SUCCESS
AB Background Laparoscopic gastric bypass (LGB) surgery markedly increases percent excess weight loss (%EWL) and obesity-related co-morbidities. However, poor study quality and minimal exploration of clinical, behavioral, and psychosocial mechanisms of weight loss have characterized research to date.
   Methods We conducted a comprehensive assessment of n=100 LGB patients surveyed 2-3 years following surgery using standardized measures.
   Results Mean %EWL at follow-up was 59.1+/-17.2%. This high level of weight loss was associated with a low rate of metabolic syndrome (10.6%), although medications were commonly used to achieve control. Mean adherence to daily vitamin and mineral supplements important to the management of LGB was only 57.6%, and suboptimal blood chemistry levels were found for ferritin (32% of patients), hematocrit (27%), thiamine (25%), and vitamin D (19%). Aerobic exercise level (R-2=0.08) and pre-surgical weight (R-2=0.04) were significantly associated with %EWL, but recommended eating style, fluid intake, clinic follow-up, and support group attendance were not. Psychosocial adjustment results showed an absence of symptomatic depression (0%), common use of antidepressant medications (32.0%), low emotional distress related to the post-surgical lifestyle (19.8+/-14.0; scale range 0-100), a high level of perceived benefit from weight loss in terms of functioning and emotional well-being (82.7+/-17.9; scale range 0-100), and a change in marital status for 26% of patients.
   Conclusions At 2-3 years following LGB surgery aerobic exercise, but not diet, fluid intake, or attendance at clinic visits or support groups, is associated with %EWL. Depression is symptomatically controlled by medications, lifestyle related distress is low, and marital status is significantly impacted.
C1 [Welch, Garry; Wesolowski, Cheryl; Kuhn, Jay; Romanelli, John] Baystate Med Ctr, Weight Loss Surg Program, Springfield, MA 01199 USA.
   [Garb, Jane] Baystate Med Ctr, Dept Acad Affairs, Springfield, MA 01199 USA.
   [Allen, Nancy] Baystate Med Ctr, Dept Endocrinol & Diabet, Springfield, MA 01199 USA.
C3 Baystate Medical Center; Baystate Medical Center; Baystate Medical
   Center
RP Welch, G (corresponding author), Baystate Med Ctr, Weight Loss Surg Program, 140 High St,Room 2104, Springfield, MA 01199 USA.
EM Garry.Welch@BHS.Org
RI Romanelli, John/AAX-1946-2020
OI Allen, Nancy A./0000-0001-7358-2265
CR Ainsworth BE, 2000, MED SCI SPORT EXER, V32, pS498, DOI 10.1097/00005768-200009001-00009
   ANDREWS G, 2003, CARING SURG WEIGHT L
   [Anonymous], PHYS ACT GUID ADV CO
   [Anonymous], 1975, Technical Report Research Branch Report
   [Anonymous], 2000, DIAGN STAT MAN MENT
   [Anonymous], SURG MANAGEMENT OBES
   ASMBS, AM SOC MET BAR SURG
   BERNADT MW, 1982, LANCET, V1, P325
   Buchwald H, 2004, JAMA-J AM MED ASSOC, V292, P1724, DOI 10.1001/jama.292.14.1724
   Colles SL, 2006, OBES SURG, V16, P811, DOI 10.1381/096089206777822160
   Deitel M, 2007, OBES SURG, V17, P565, DOI 10.1007/s11695-007-9116-0
   DIROCCO JD, 2007, SURG MANAGEMENT OBES
   DIXON JB, 2007, SURG MANAGEMENT OBES, P357
   Elkins G, 2005, OBES SURG, V15, P546, DOI 10.1381/0960892053723385
   EWING JA, 1984, JAMA-J AM MED ASSOC, V252, P1905, DOI 10.1001/jama.252.14.1905
   Garb J, 2009, OBES SURG, V19, P1447, DOI 10.1007/s11695-009-9927-2
   Hatoum IJ, 2009, OBESITY, V17, P92, DOI 10.1038/oby.2008.507
   KITCHENS JM, 1994, JAMA-J AM MED ASSOC, V272, P1782, DOI 10.1001/jama.272.22.1782
   Kroenke K, 2002, PSYCHIAT ANN, V32, P509, DOI 10.3928/0048-5713-20020901-06
   Lee WJ, 2004, ARCH SURG-CHICAGO, V139, P1088, DOI 10.1001/archsurg.139.10.1088
   Lutfi R, 2006, SURG ENDOSC, V20, P864, DOI 10.1007/s00464-005-0115-8
   Magro DO, 2008, OBES SURG, V18, P648, DOI 10.1007/s11695-007-9265-1
   MAGRO DO, 2006, OBES SURG, V16, P811
   McMahon MM, 2006, MAYO CLIN PROC, V81, pS34
   Mondolfi RN, 2007, AM J CARDIOL, V100, P1651, DOI 10.1016/j.amjcard.2007.06.072
   National Institutes of Health (NIH), 2001, NIH PUBL
   *NIH, LONG ASS BAR SURG
   Odom J, 2010, OBES SURG, V20, P349, DOI 10.1007/s11695-009-9895-6
   ORIA HE, 2007, SURG MANAGEMENT OBES, P345
   Poole NA, 2005, OBES SURG, V15, P261, DOI 10.1381/0960892053268499
   Santri H., 2007, Surgical management of obesity
   *SAS INC, 2005, STAT AN SYST SAS 9 1
   Saunders R, 2004, OBES SURG, V14, P98, DOI 10.1381/096089204772787374
   Silver HJ, 2006, OBES SURG, V16, P859, DOI 10.1381/096089206777822296
   *SPSS INC, 1999, STAT PACK SOC SCI SP
   Sturm R, 2007, PUBLIC HEALTH, V121, P492, DOI 10.1016/j.puhe.2007.01.006
   van Hout GCM, 2005, OBES SURG, V15, P552, DOI 10.1381/0960892053723484
   Weinstein AR, 2004, JAMA-J AM MED ASSOC, V292, P1188, DOI 10.1001/jama.292.10.1188
   Welch G, 2008, BARIAT NURS SURG PAT, V3, P159, DOI 10.1089/bar.2008.9973
   Welch G, 2008, OBES SURG, V18, P517, DOI 10.1007/s11695-007-9269-x
   WOLF AM, 1994, INT J EPIDEMIOL, V23, P991, DOI 10.1093/ije/23.5.991
   MACARTHUR INITIATIVE
NR 42
TC 40
Z9 45
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0960-8923
EI 1708-0428
J9 OBES SURG
JI Obes. Surg.
PD JAN
PY 2011
VL 21
IS 1
BP 18
EP 28
DI 10.1007/s11695-009-0069-3
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 709FP
UT WOS:000286423600004
PM 20087678
DA 2025-06-11
ER

PT J
AU Sheng, W
   Ji, G
   Zhang, L
AF Sheng, Wei
   Ji, Guang
   Zhang, Li
TI Management of non-alcoholic fatty liver disease patients with sleep
   apnea syndrome
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Nonalcoholic fatty liver disease; Sleep apnea syndrome; Obesity;
   Obstructive sleep apnea hypopnea syndrome; Continuous positive airway
   pressure; Management
ID POSITIVE AIRWAY PRESSURE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; 3.0 MG; THERAPY; STEATOHEPATITIS; ASSOCIATION; ACIDS;
   LIRAGLUTIDE
AB Nonalcoholic fatty liver disease (NAFLD) is strongly associated with sleep apnea syndrome (SAS). Many NAFLD patients have SAS, and obstructive sleep apnea hypopnea syndrome is also considered to be an independent risk factor for NAFLD, as it contributes to the progression of NAFLD via oxidative stress, lipid peroxidation, inflammation, and insulin resistance. This review aims to provide some recommendations for the management of NAFLD patients with SAS, including diet, exercise, weight loss, and continuous positive airway pressure. This review also highlights the importance of effective strategies in NAFLD prevention and treatment.
C1 [Sheng, Wei; Ji, Guang; Zhang, Li] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Inst Digest Dis, Shanghai 200032, Peoples R China.
   [Zhang, Li] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Inst Digest Dis, 725 South Wanping Rd, Shanghai 200032, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine
RP Zhang, L (corresponding author), Shanghai Univ Tradit Chinese Med, Longhua Hosp, Inst Digest Dis, 725 South Wanping Rd, Shanghai 200032, Peoples R China.
EM zhangli.hl@163.com
FU Project of Shanghai Hospital Development Center [SHDC2020CR4044]
FX Supported by the Project of Shanghai Hospital Development Center, No.
   SHDC2020CR4044.
CR Agrawal S, 2015, HEPATOL INT, V9, P283, DOI 10.1007/s12072-015-9615-3
   Ahmed MH, 2010, WORLD J GASTROENTERO, V16, P4243, DOI 10.3748/wjg.v16.i34.4243
   Albaugh Vance L, 2016, F1000Res, V5, DOI 10.12688/f1000research.7240.1
   Arapis K, 2019, SURG OBES RELAT DIS, V15, P23, DOI 10.1016/j.soard.2018.09.487
   Armstrong MJ, 2016, LANCET, V387, P679, DOI 10.1016/S0140-6736(15)00803-X
   Aron-Wisnewsky J, 2016, METABOLISM, V65, P1124, DOI 10.1016/j.metabol.2016.05.004
   Bach-Faig A, 2011, PUBLIC HEALTH NUTR, V14, P2274, DOI 10.1017/S1368980011002515
   Bahr K, 2022, BIOLOGY-BASEL, V11, DOI 10.3390/biology11010010
   Bajantri B, 2018, GASTROENTEROL RES, V11, P252, DOI 10.14740/gr1033w
   Barceló A, 2011, EUR RESPIR J, V37, P1418, DOI 10.1183/09031936.00050410
   Bettini S, 2022, EAT WEIGHT DISORD-ST, V27, P335, DOI 10.1007/s40519-021-01182-9
   Bhatt SP, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0245408
   Bhatt SP, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0203182
   Blackman A, 2016, INT J OBESITY, V40, P1310, DOI 10.1038/ijo.2016.52
   Boden G, 2001, DIABETES, V50, P1612, DOI 10.2337/diabetes.50.7.1612
   Buzzetti E, 2016, METABOLISM, V65, P1038, DOI 10.1016/j.metabol.2015.12.012
   Carneiro-Barrera A, 2022, NUTRIENTS, V14, DOI 10.3390/nu14132731
   Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI 10.1002/hep.29367
   Chen LD, 2018, CLIN RESPIR J, V12, P373, DOI 10.1111/crj.12554
   Chin K, 2003, AM J MED, V114, P370, DOI 10.1016/S0002-9343(02)01570-X
   Cho K, 2022, OBES REV, V23, DOI 10.1111/obr.13464
   Cunha GM, 2018, ABDOM RADIOL, V43, P2340, DOI 10.1007/s00261-018-1504-5
   del Genio G, 2016, SURG OBES RELAT DIS, V12, P70, DOI 10.1016/j.soard.2015.02.020
   Dewan NA, 2015, CHEST, V147, P266, DOI 10.1378/chest.14-0500
   Dobrosielski DA, 2017, EUR RESPIR REV, V26, DOI 10.1183/16000617.0110-2016
   EASL, 2016, OBESITY FACTS, V9, P65, DOI [10.1159/000443344, 10.1007/s00125-016-3902-y, 10.1016/j.jhep.2015.11.004]
   Eslam M, 2020, HEPATOL INT, V14, P889, DOI 10.1007/s12072-020-10094-2
   Eslam M, 2020, J HEPATOL, V73, P202, DOI 10.1016/j.jhep.2020.03.039
   Franco I, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010066
   Fromenty B, 2004, DIABETES METAB, V30, P121, DOI 10.1016/S1262-3636(07)70098-8
   Fu YZ, 2022, HEPATOL INT, V16, P824, DOI 10.1007/s12072-022-10347-2
   Greenburg DL, 2009, AM J MED, V122, P535, DOI 10.1016/j.amjmed.2008.10.037
   Gu CJ, 2017, MED HYPOTHESES, V108, P161, DOI 10.1016/j.mehy.2017.09.007
   Hang LW, 2017, SLEEP BREATH, V21, P461, DOI 10.1007/s11325-016-1439-4
   Hernández A, 2020, BBA-MOL BASIS DIS, V1866, DOI 10.1016/j.bbadis.2020.165753
   Iqbal J, 2022, OBES REV, V23, DOI 10.1111/obr.13435
   James OFW, 1998, J HEPATOL, V29, P495, DOI 10.1016/S0168-8278(98)80073-1
   Jullian-Desayes I, 2016, RESPIROLOGY, V21, P378, DOI 10.1111/resp.12672
   Jun JC, 2011, SLEEP, V34, P1207, DOI 10.5665/SLEEP.1240
   Khoo J, 2017, DIABETES OBES METAB, V19, P1814, DOI 10.1111/dom.13007
   Kim D, 2018, J CLIN SLEEP MED, V14, P1315, DOI 10.5664/jcsm.7262
   Kim N, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0271021
   Kohler M, 2009, RESPIRATION, V78, P141, DOI 10.1159/000170785
   Lassailly G, 2015, GASTROENTEROLOGY, V149, P379, DOI 10.1053/j.gastro.2015.04.014
   Lee HW, 2020, HEPATOLOGY, V72, P1230, DOI 10.1002/hep.31142
   Libman E, 2017, Sleep Disord, V2017, P2760650, DOI 10.1155/2017/2760650
   Lin MT, 2015, SLEEP BREATH, V19, P809, DOI 10.1007/s11325-014-1082-x
   Liu YP, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/9583286
   Madsbad S, 2014, LANCET DIABETES ENDO, V2, P152, DOI 10.1016/S2213-8587(13)70218-3
   Masarone M, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/9547613
   Mascaro CM., 2022, Nutrients, V14
   Musso G, 2013, OBES REV, V14, P417, DOI 10.1111/obr.12020
   Ng SSS, 2021, AM J RESP CRIT CARE, V203, P493, DOI 10.1164/rccm.202005-1868OC
   Ong CW, 2013, SLEEP MED REV, V17, P123, DOI 10.1016/j.smrv.2012.05.002
   Oyama J, 2012, CLIN CARDIOL, V35, P231, DOI 10.1002/clc.21010
   Ozturk A., 2022, Cureus, V14, DOI DOI 10.7759/CUREUS.27992
   Parikh MP, 2019, CLIN LIVER DIS, V23, P363, DOI 10.1016/j.cld.2019.01.001
   Pi-Sunyer X, 2015, NEW ENGL J MED, V373, P11, DOI 10.1056/NEJMoa1411892
   PORIES WJ, 1995, ANN SURG, V222, P339, DOI 10.1097/00000658-199509000-00011
   Przybylowski T, 2007, J PHYSIOL PHARMACOL, V58, P563
   Schiavo L, 2022, OBES SURG, V32, P634, DOI 10.1007/s11695-021-05811-1
   Schwab RJ, 2003, AM J RESP CRIT CARE, V168, P522, DOI 10.1164/rccm.200208-866OC
   Serviddio G, 2008, MOL ASPECTS MED, V29, P22, DOI 10.1016/j.mam.2007.09.014
   SHELTON KE, 1993, AM REV RESPIR DIS, V148, P462, DOI 10.1164/ajrccm/148.2.462
   Simpson L, 2015, J CLIN SLEEP MED, V11, P1091, DOI 10.5664/jcsm.5078
   Sofi F, 2014, PUBLIC HEALTH NUTR, V17, P2769, DOI 10.1017/S1368980013003169
   Sundaram SS, 2018, J PEDIATR-US, V198, P67, DOI 10.1016/j.jpeds.2018.03.028
   Sundaram SS, 2016, J HEPATOL, V65, P560, DOI 10.1016/j.jhep.2016.04.010
   Tang A, 2013, RADIOLOGY, V267, P422, DOI 10.1148/radiol.12120896
   Tilg H, 2010, HEPATOLOGY, V52, P1836, DOI 10.1002/hep.24001
   Tumova J, 2016, PHYSIOL RES, V65, P193, DOI 10.33549/physiolres.932993
   Umbro I, 2020, WORLD J GASTROENTERO, V26, DOI 10.3748/wjg.v26.i20.2669
   Verwimp J, 2013, SLEEP BREATH, V17, P1039, DOI 10.1007/s11325-012-0796-x
   Vgontzas AN, 2000, J CLIN ENDOCR METAB, V85, P1151, DOI 10.1210/jc.85.3.1151
   Vilar-Gomez E, 2018, J HEPATOL, V68, P305, DOI 10.1016/j.jhep.2017.11.013
   Wang F, 2019, SLEEP BREATH, V23, P1011, DOI 10.1007/s11325-019-01804-8
   Winslow DH, 2012, SLEEP, V35, P1529, DOI 10.5665/sleep.2204
   Xanthopoulos MS, 2018, METABOLISM, V84, P109, DOI 10.1016/j.metabol.2018.01.022
   Xie XM, 2013, SLEEP MED, V14, P1139, DOI 10.1016/j.sleep.2013.07.006
   Younossi ZM, 2021, AM J GASTROENTEROL, V116, P254, DOI 10.14309/ajg.0000000000001054
   Zhang YX, 2020, OBES SURG, V30, P3803, DOI 10.1007/s11695-020-04696-w
   Zheng JL, 2022, CLIN NUTR, V41, P2295, DOI 10.1016/j.clnu.2022.08.018
NR 82
TC 2
Z9 2
U1 2
U2 12
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD NOV 21
PY 2022
VL 28
IS 43
BP 6099
EP 6108
DI 10.3748/wjg.v28.i43.6099
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 6T4HF
UT WOS:000893638200003
PM 36483151
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Blum, A
AF Blum, A.
TI Gender differences in vascular aging and in coronary artery disease
   pathophysiology
SO QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
LA English
DT Review
ID IMPROVES ENDOTHELIAL FUNCTION; RISK-FACTORS; CARDIOVASCULAR-DISEASE;
   MYOCARDIAL-INFARCTION; MENOPAUSAL TRANSITION; SEDENTARY OCCUPATIONS;
   METABOLIC SYNDROME; OXIDATIVE STRESS; WOMENS HEALTH; NITRIC-OXIDE
AB Women have a clinical advantage over men in relation to atherosclerotic cardiovascular disease (CVD) (morbidity and mortality). This advantage disappears once women become older, and in their seventh decade, the risk to develop CVD equals men at that age. There have been several theories about this gender difference that were related to hormones, and the different morphology and physiology that characterize the cardiovascular system in women. In this review, the different mechanisms will be reviewed and discussed.
C1 [Blum, A.] Bar Ilan Univ, Azrieli Fac Med, Tzafon Med Ctr, Dept Med, IL-15208 Lower Galilee, Israel.
C3 Bar Ilan University
RP Blum, A (corresponding author), Bar Ilan Univ, Azrieli Fac Med, Tzafon Med Ctr, Dept Med, IL-15208 Lower Galilee, Israel.
EM ablum@tzmc.health.gov.il
RI Blum, Arnon/IWD-5144-2023
OI Blum, Arnon/0000-0003-3863-4036
CR Adawi M, 2020, J INTERN MED, V288, P439, DOI 10.1111/joim.13087
   Akintomide AO., 2016, J CARDIOL CURR RES, V7, P2373
   Al Suwaidi J, 2000, CIRCULATION, V101, P948, DOI 10.1161/01.CIR.101.9.948
   Alter DA, 2002, J AM COLL CARDIOL, V39, P1909, DOI 10.1016/S0735-1097(02)01892-2
   Anand SS, 2008, EUR HEART J, V29, P932, DOI 10.1093/eurheartj/ehn018
   Blum A, 2000, J AM COLL CARDIOL, V35, P271, DOI 10.1016/S0735-1097(99)00553-7
   Blum A, 2009, GENDER MED, V6, P410, DOI 10.1016/j.genm.2009.09.005
   Bromberger JT, 2015, PSYCHOL MED, V45, P1653, DOI 10.1017/S0033291714002773
   Bromberger JT, 2011, PSYCHOL MED, V41, P1879, DOI 10.1017/S003329171100016X
   Bromberger JT, 2007, J AFFECT DISORDERS, V103, P267, DOI 10.1016/j.jad.2007.01.034
   Buchthal SD, 2000, NEW ENGL J MED, V342, P829, DOI 10.1056/NEJM200003233421201
   Cagnacci A, 2012, CLIMACTERIC, V15, P157, DOI 10.3109/13697137.2011.617852
   Cagnacci A, 2015, GYNECOL ENDOCRINOL, V31, P359, DOI 10.3109/09513590.2014.998188
   Chomistek AK, 2018, J AM HEART ASSOC, V7, DOI [10.1161/JAHA.117.008234, 10.1161/jaha.117.008234]
   Cohen LS, 2006, ARCH GEN PSYCHIAT, V63, P385, DOI 10.1001/archpsyc.63.4.385
   Cook NR, 2006, ANN INTERN MED, V145, P21, DOI 10.7326/0003-4819-145-1-200607040-00128
   Gladwin MT, 2003, CIRCULATION, V107, P271, DOI 10.1161/01.CIR.0000044943.12533.A8
   Hasin DS, 2005, ARCH GEN PSYCHIAT, V62, P1097, DOI 10.1001/archpsyc.62.10.1097
   Heitzer T, 2001, CIRCULATION, V104, P2673, DOI 10.1161/hc4601.099485
   Hildreth KL, 2018, MENOPAUSE, V25, P1011, DOI 10.1097/GME.0000000000001112
   Hildreth KL, 2014, MENOPAUSE, V21, P624, DOI [10.1097/GME.0000000000000116, 10.1097/gme.0000000000000116]
   Holder SM, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.118.010994
   Kessler RC, 2003, J AFFECT DISORDERS, V74, P5, DOI 10.1016/S0165-0327(02)00426-3
   Kip KE, 2004, CIRCULATION, V109, P706, DOI 10.1161/01.CIR.0000115514.44135.A8
   Koh KK, 1999, CIRCULATION, V100, P1851, DOI 10.1161/01.CIR.100.18.1851
   Lambrinoudaki I, 2012, CLIMACTERIC, V15, P350, DOI 10.3109/13697137.2011.618564
   Laurent S, 2006, EUR HEART J, V27, P2588, DOI 10.1093/eurheartj/ehl254
   Lippincott MF, 2008, AM J CARDIOL, V102, P820, DOI 10.1016/j.amjcard.2008.05.020
   Lippincott MF, 2008, AM J CARDIOL, V102, P348, DOI 10.1016/j.amjcard.2008.03.069
   Maas AHEM, 2009, NETH HEART J, V17, P68, DOI 10.1007/BF03086220
   Mathews L, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0186448
   MATTHEWS KA, 1989, NEW ENGL J MED, V321, P641, DOI 10.1056/NEJM198909073211004
   Moreau KL, 2013, J CLIN ENDOCR METAB, V98, P4507, DOI 10.1210/jc.2013-2183
   Moreau KL, 2013, ATHEROSCLEROSIS, V230, P390, DOI 10.1016/j.atherosclerosis.2013.07.057
   Moreau KL, 2012, J CLIN ENDOCR METAB, V97, P4692, DOI 10.1210/jc.2012-2244
   Moreau KL, 2012, AM J PHYSIOL-HEART C, V302, pH1211, DOI 10.1152/ajpheart.01065.2011
   Moreau KL, 2003, CARDIOVASC RES, V57, P861, DOI 10.1016/S0008-6363(02)00777-0
   Moreau KL., 2014, Adv Vasc Med, V2014, P1, DOI DOI 10.1155/2014/204390
   Mosca L, 2004, J AM COLL CARDIOL, V43, P900, DOI 10.1016/j.jacc.2004.02.001
   Nicholls SJ, 2007, J AM COLL CARDIOL, V49, P1546, DOI 10.1016/j.jacc.2006.12.039
   Pabbidi MR, 2018, AM J PHYSIOL-HEART C, V315, pH1499, DOI 10.1152/ajpheart.00194.2018
   Quesada O, 2022, EUR J PREV CARDIOL, V29, P1608, DOI 10.1093/eurjpc/zwac046
   Ramezankhani A, 2022, CARDIOVASC DIABETOL, V21, DOI 10.1186/s12933-022-01665-8
   Rossi R, 2008, J AM COLL CARDIOL, V51, P997, DOI 10.1016/j.jacc.2007.11.044
   Schächinger V, 2000, CIRCULATION, V101, P1899, DOI 10.1161/01.CIR.101.16.1899
   Shaw LJ, 2004, CIRCULATION, V109, pE56, DOI 10.1161/01.CIR.0000116210.70548.2A
   Shaw LJ, 1999, J NUCL CARDIOL, V6, P559, DOI 10.1016/S1071-3581(99)90091-0
   Tchernof A, 1998, CORONARY ARTERY DIS, V9, P503, DOI 10.1097/00019501-199809080-00006
   Tehrani FR, 2015, ACTA OBSTET GYN SCAN, V94, P708, DOI 10.1111/aogs.12655
   Thom T, 2006, CIRCULATION, V113, pE85, DOI 10.1161/CIRCULATIONAHA.105.171600
   Vaccarino V, 1999, NEW ENGL J MED, V341, P217, DOI 10.1056/NEJM199907223410401
   Vaccarino V, 2001, ANN INTERN MED, V134, P173, DOI 10.7326/0003-4819-134-3-200102060-00007
   von Mering GO, 2004, CIRCULATION, V109, P722, DOI 10.1161/01.CIR.0000115525.92645.16
   Wessel TR, 2004, JAMA-J AM MED ASSOC, V292, P1179, DOI 10.1001/jama.292.10.1179
   Worsley R, 2014, MATURITAS, V77, P111, DOI 10.1016/j.maturitas.2013.11.007
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
NR 56
TC 5
Z9 5
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1460-2725
EI 1460-2393
J9 QJM-INT J MED
JI QJM-An Int. J. Med.
PD OCT 6
PY 2023
VL 116
IS 9
BP 745
EP 749
DI 10.1093/qjmed/hcad027
EA FEB 2023
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA U1LN0
UT WOS:000945596300001
PM 36821436
DA 2025-06-11
ER

PT J
AU Akbay, E
   Ulusu, NN
   Törüner, F
   Ayvaz, G
   Taneri, F
   Aktürk, M
   Arslan, M
   Karasu, Ç
AF Akbay, E
   Ulusu, NN
   Törüner, F
   Ayvaz, G
   Taneri, F
   Aktürk, M
   Arslan, M
   Karasu, Ç
TI Effects of rosiglitazone treatment on the pentose phosphate pathway and
   glutathione-dependent enzymes in liver and kidney of rats fed a high-fat
   diet
SO CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE rosiglitazone; pentose phosphate pathway; glutathione-dependent
   metabolism; metabolic syndrome; high-fat diet; rat; obesity
ID PEROXISOME PROLIFERATORS; ANTIOXIDANT ENZYMES; LIPID-PEROXIDATION;
   OXIDATIVE STRESS; RECEPTOR-GAMMA; TROGLITAZONE; PURIFICATION;
   HEPATOCYTES; MECHANISMS; LEPTIN
AB Background: Animals fed high-fat diets have been shown to develop hyperglycemia, insulin resistance, hyperlipidemia, and moderate obesity, which resemble the human metabolic syndrome. Obesity, the metabolic syndrome, and some thiazolidinediones, which act as insulin sensitizers, may increase oxidative stress, and/or influence the levels of cellular reducing equivalents and homeostasis.
   Objective: This study investigated the effects of a high-fat diet, rosiglitazone, or a high-fat diet plus rosiglitazone on metabolic syndrome parameters and crucial liver and kidney enzyme activities in rats.
   Methods: Male Wistar rats were assigned to 4 groups (n = 6 per group): (1) the fat (F) group was fed a rodent diet comprising 45 kcal% fat, (2) the rosiglitazone (R) group was fed a standard rat chow comprising 4.97 kcal% fat plus rosiglitazone (3 mg/kg(.)d), (3) the fat + rosiglitazone (FR) group was fed a rodent diet comprising 45 kcal% fat (as lard, product D12451) plus rosiglitazone (3 mg/kg(.)d), and (4) the control (C) group was fed a standard rat chow comprising 4.97 kcal% fat. Animals were housed for 4 weeks, at which time the liver and kidney were isolated for spectrophotometric determination of enzyme activities. Body weight was measured before treatment (baseline) and then weekly throughout the study. Adiposity was measured at the end of the 4 weeks.
   Results: The activities of glucose-6-phosphate dehydrogenase (GPD), 6-phosphogluconate dehydrogenase (6-PGD), glutathione reductase (GR), and glutathione-S-transferase (GST) were significantly reduced in the livers of groups F, R, and FR compared with group C (all P < 0.05). Kidney G6PD, 6-PGD,and GR were found to be significantly lower in group R compared with the other groups (all P < 0.05). Kidney GST was similar in all groups. Plasma glucose, triglyceride, and insulin concentrations were significantly higher than in group F versus the other groups (all P < 0.05). Adiposity was increased in groups F and FR compared with groups C and R (all P < 0.05). Serum cholesterol concentrations were similar in all groups.
   Conclusions: In this study, high-fat diet in rats decreased the enzyme activities responsible for pentose phosphate pathway and glutathione-dependent metabolism in liver but not in kidney. Similarly, these enzyme activities were inhibited with rosiglitazone treatment alone in both organs. (Curr Ther Res Clin Exp. 2004;65:79-89) Copyright (C) 2004 Excerpta Medica, Inc.
C1 Gazi Univ, Fac Med, Dept Med Pharmacol, TR-06510 Ankara, Turkey.
   Gazi Univ, Fac Med, Dept Endocrinol Metab, TR-06510 Ankara, Turkey.
   Gazi Univ, Fac Med, Dept Surg, TR-06510 Ankara, Turkey.
   Mersin Univ, Fac Med, Dept Endocrinol, Mersin, Turkey.
   Hacettepe Univ, Fac Med, Dept Biochem, TR-06100 Ankara, Turkey.
C3 Gazi University; Gazi University; Gazi University; Mersin University;
   Hacettepe University
RP Karasu, Ç (corresponding author), Gazi Univ, Fac Med, Dept Med Pharmacol, TR-06510 Ankara, Turkey.
EM karasu@gazi.edu.tr
RI Karasu, Çimen/JVZ-4637-2024; Toruner, Fusun/ABC-4701-2021; nn,
   ulusu/AAF-1827-2019
OI Toruner, Fusun/0000-0002-6168-937X; Ulusu, Nuray
   Nuriye/0000-0002-3173-1389; Karasu, Cimen/0000-0002-0954-8465
CR ACAN NL, 1989, FEBS LETT, V250, P72, DOI 10.1016/0014-5793(89)80687-8
   ASHBY J, 1994, HUM EXP TOXICOL, V13, pS1, DOI 10.1177/096032719401300201
   Ashida H, 1998, J NUTR SCI VITAMINOL, V44, P89, DOI 10.3177/jnsv.44.89
   AYALA A, 1991, MOL CELL BIOCHEM, V105, P1
   BARNETT CR, 1992, BIOCHEM PHARMACOL, V43, P1868, DOI 10.1016/0006-2952(92)90724-W
   BASAGA HS, 1990, BIOCHEM CELL BIOL, V68, P989, DOI 10.1139/o90-146
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   CAREY DG, 2000, DIABETOLOGIA S1, V43, pA181
   Chen LC, 2001, J BIOCHEM MOL TOXIC, V15, P107, DOI 10.1002/jbt.6
   CHEN LC, 1993, LIPIDS, V28, P657, DOI 10.1007/BF02536062
   Deneke S.M., 1989, AM J PHYSIOL, V257, P163
   HABIG WH, 1974, J BIOL CHEM, V249, P7130
   Hayes JD, 1999, FREE RADICAL RES, V31, P273, DOI 10.1080/10715769900300851
   LAWRENCE RA, 1978, J NUTR, V108, P981, DOI 10.1093/jn/108.6.981
   Lennon AM, 2002, J BIOL CHEM, V277, P29681, DOI 10.1074/jbc.M201517200
   Lloyd S, 2002, CHEM-BIOL INTERACT, V142, P57, DOI 10.1016/S0009-2797(02)00054-6
   Malinowski JM, 2000, CLIN THER, V22, P1151, DOI 10.1016/S0149-2918(00)83060-X
   Narayanan PK, 2003, CYTOM PART A, V52A, P28, DOI 10.1002/cyto.a.10011
   O'Brien ML, 2001, TOXICOL SCI, V60, P271, DOI 10.1093/toxsci/60.2.271
   Pearse B M, 1975, Methods Enzymol, V41, P220
   Pickavance LC, 1999, BRIT J PHARMACOL, V128, P1570, DOI 10.1038/sj.bjp.0702932
   REDDY JK, 1982, ANN NY ACAD SCI, V386, P81, DOI 10.1111/j.1749-6632.1982.tb21409.x
   SALAZAR DE, 1994, INT J OBESITY, V18, P25
   Saltiel AR, 1996, DIABETES, V45, P1661, DOI 10.2337/diabetes.45.12.1661
   SEVANIAN A, 1985, ANNU REV NUTR, V5, P365, DOI 10.1146/annurev.nu.05.070185.002053
   SHAPIRO R, 2001, 83 ANN M END SOC DEN
   Tallman DL, 2003, J NUTR BIOCHEM, V14, P17, DOI 10.1016/S0955-2863(02)00228-0
   Teruel T, 2003, J BIOL CHEM, V278, P263, DOI 10.1074/jbc.M207200200
   Tettey JN, 2001, CHEM RES TOXICOL, V14, P965, DOI 10.1021/tx0001981
   Trevisan M, 2001, AM J EPIDEMIOL, V154, P348, DOI 10.1093/aje/154.4.348
   Ulusu NN, 1999, INT J BIOCHEM CELL B, V31, P787, DOI 10.1016/S1357-2725(99)00019-9
   Watson AM, 1999, DRUG METAB DISPOS, V27, P695
   Willson TM, 2001, ANNU REV BIOCHEM, V70, P341, DOI 10.1146/annurev.biochem.70.1.341
   WOOD T, 1986, CELL BIOCHEM FUNCT, V4, P241, DOI 10.1002/cbf.290040403
   YORK JL, 1994, P SOC EXP BIOL MED, V205, P186
NR 35
TC 13
Z9 14
U1 0
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0011-393X
J9 CURR THER RES CLIN E
JI Curr. Ther. Res.-Clin. Exp.
PD JAN-FEB
PY 2004
VL 65
IS 1
BP 79
EP 89
DI 10.1016/S0011-393X(04)90007-0
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 805TC
UT WOS:000220387600008
PM 24936106
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Ginström, L
   Kaseva, K
   Peltonen, JE
   Saarikallio, S
   Tervaniemi, M
AF Ginstrom, Laura
   Kaseva, Kaisa
   Peltonen, Juha E.
   Saarikallio, Suvi
   Tervaniemi, Mari
TI Using music as a mood regulator in everyday life is associated with
   unfavourable health and fitness outcomes in overweight adults
SO PLOS ONE
LA English
DT Article
ID ACTIVITY QUESTIONNAIRE IPAQ; TIME PHYSICAL-ACTIVITY; ALVEOLAR
   GAS-EXCHANGE; BODY-MASS INDEX; METABOLIC SYNDROME; CARDIORESPIRATORY
   FITNESS; TISSUE DEOXYGENATION; EMOTION REGULATION; EXERCISE DOMAIN;
   SELF-REGULATION
AB Individual traits and habits have shown to be associated with health and health behaviour. One such habit is how individuals use music. This study aimed to examine if using music as a mood regulator is related to risk factors of lifestyle diseases. Participants who joined the present Motivation Makes the Move! lifestyle intervention were overweight and sedentary adults (n = 76, ages 19-40). They answered questionnaires about physical activity and use of music. They also underwent a cardiopulmonary exercise test and their body composition was assessed. Additionally, the analyses' robustness was tested through controlling for physical, sociodemographic and psychological health related factors. We observed that despite the participants' self-reported commitment to regular physical activity, their fitness level was poor. Using music as a mood regulator was associated with lower cardiorespiratory fitness. Use of music was also positively linked to body fat percentage, although this finding did not remain significant after adjusting for age, educational level and experienced health. We urge future research to address the relationship between music use and risk factors of lifestyle diseases in a population sample.
C1 [Ginstrom, Laura; Tervaniemi, Mari] Univ Helsinki, Fac Educ Sci, Ctr Excellence Mus Mind Body & Brain, Helsinki, Finland.
   [Ginstrom, Laura; Kaseva, Kaisa; Peltonen, Juha E.] Univ Helsinki, Fac Med, Sports & Exercise Med, Helsinki, Finland.
   [Ginstrom, Laura; Kaseva, Kaisa; Peltonen, Juha E.] Fdn Sports & Exercise Med, Helsinki Sports & Exercise Med Clin HULA, Helsinki, Finland.
   [Kaseva, Kaisa] Univ Helsinki, Fac Educ Sci, Dept Educ, Helsinki, Finland.
   [Saarikallio, Suvi] Univ Jyvaskyla, Ctr Excellence Mus Mind Body & Brain, Helsinki, Finland.
   [Tervaniemi, Mari] Univ Helsinki, Fac Med, Dept Psychol, Cognit Brain Res Unit, Helsinki, Finland.
C3 University of Helsinki; University of Helsinki; University of Helsinki;
   University of Jyvaskyla; University of Helsinki
RP Tervaniemi, M (corresponding author), Univ Helsinki, Fac Educ Sci, Ctr Excellence Mus Mind Body & Brain, Helsinki, Finland.; Tervaniemi, M (corresponding author), Univ Helsinki, Fac Med, Dept Psychol, Cognit Brain Res Unit, Helsinki, Finland.
EM mari.tervaniemi@helsinki.fi
OI Kaseva, Kaisa/0000-0002-3712-7756; Saarikallio,
   Suvi/0000-0002-4647-8048; Tervaniemi, Mari/0000-0002-9651-2929
FU Business Finland
FX We gratefully acknowledge Dr. Daniela Eklund, Sanni Malander, and Enni
   Heikura for their contribution in data acquisition and coding and Dr.
   Kaisamari Kostilainen for her expertise in planning the study.
CR Ainsworth BE, 2011, MED SCI SPORT EXER, V43, P1575, DOI 10.1249/MSS.0b013e31821ece12
   Alluri V, 2022, PSYCHOL MUSIC, V50, P1779, DOI 10.1177/03057356211065061
   Anandacoomarasamy A, 2008, INT J OBESITY, V32, P211, DOI 10.1038/sj.ijo.0803715
   [Anonymous], 2024, Huslab reference guidelines
   Baltazar M, 2019, MUSIC SCI, V23, P177, DOI 10.1177/1029864917715061
   Bernstein EE, 2018, BEHAV RES THER, V109, P29, DOI 10.1016/j.brat.2018.07.010
   Bogg T, 2004, PSYCHOL BULL, V130, P887, DOI 10.1037/0033-2909.130.6.887
   Booth FW, 2012, COMPR PHYSIOL, V2, P1143, DOI 10.1002/cphy.c110025
   Carlson E, 2021, FRONT PSYCHOL, V12, DOI 10.3389/fpsyg.2021.647756
   Chin TC, 2014, PSYCHOL MUSIC, V42, P692, DOI 10.1177/0305735613489916
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   Cohen AK, 2013, OBES REV, V14, P989, DOI 10.1111/obr.12062
   Di Angelantonio E, 2016, LANCET, V388, P776, DOI 10.1016/S0140-6736(16)30175-1
   Ekblom Ö, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0131586
   Gallagher D, 1996, AM J EPIDEMIOL, V143, P228, DOI 10.1093/oxfordjournals.aje.a008733
   Getz LM, 2014, PSYCHOL MUSIC, V42, P71, DOI 10.1177/0305735612456727
   Gómez-Ambrosi J, 2011, OBESITY, V19, P1439, DOI 10.1038/oby.2011.36
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Hagströmer M, 2006, PUBLIC HEALTH NUTR, V9, P755, DOI 10.1079/PHN2005898
   Hands B P., 2016, Journal of Women's Health, Issues and Care, V5, DOI [DOI 10.4172/2325-9795.1000238, 10.4172/2325-9795.1000238]
   Henry N, 2021, FRONT PSYCHOL, V12, DOI 10.3389/fpsyg.2021.647879
   Horber FF, 1997, NUTRITION, V13, P524, DOI 10.1016/S0899-9007(97)00031-2
   IPAQ Research Committee, 2005, Guidelines for data processing and analysis of the international physical activity questionnaire (IPAQ)-Short and long forms
   Ivan S, 2023, PHYSIOL BEHAV, V259, DOI 10.1016/j.physbeh.2022.114038
   Jing L, 2008, J SPORT MED PHYS FIT, V48, P102
   Karageorghis CI, 2012, INT REV SPORT EXER P, V5, P44, DOI 10.1080/1750984X.2011.631026
   Karageorghis CI, 2012, INT REV SPORT EXER P, V5, P67, DOI 10.1080/1750984X.2011.631027
   Karageorghis CI, 2009, J SPORT EXERCISE PSY, V31, P18, DOI 10.1123/jsep.31.1.18
   Kaseva K, 2022, JMIR FORM RES, V6, DOI 10.2196/30285
   Katsuki A, 2001, DIABETES CARE, V24, P362, DOI 10.2337/diacare.24.2.362
   Kettunen O, 2014, J SPORT MED PHYS FIT, V54, P545
   Kim JA, 2006, J KOREAN MED SCI, V21, P1048, DOI 10.3346/jkms.2006.21.6.1048
   Kolotkin RL, 2017, CLIN OBES, V7, P273, DOI 10.1111/cob.12203
   Konttinen H, 2010, AM J CLIN NUTR, V92, P1031, DOI 10.3945/ajcn.2010.29732
   Krachler B, 2015, EUR J PREV CARDIOL, V22, P1171, DOI 10.1177/2047487314557962
   Krause AE, 2021, FRONT PSYCHOL, V11, DOI 10.3389/fpsyg.2020.631033
   Kulinski J, 2022, TRENDS CARDIOVAS MED, V32, P390, DOI 10.1016/j.tcm.2021.06.004
   Laaksonen DE, 2002, DIABETES CARE, V25, P1612, DOI 10.2337/diacare.25.9.1612
   Lahey BB, 2009, AM PSYCHOL, V64, P241, DOI 10.1037/a0015309
   Lakka TA, 2003, MED SCI SPORT EXER, V35, P1279, DOI 10.1249/01.MSS.0000079076.74931.9A
   Laukka P, 2013, PSYCHOL MUSIC, V41, P198, DOI 10.1177/0305735611422507
   MacDonald R., 2012, Music, health and wellbeing, P3, DOI [10.1093/acprof:oso/9780199586974.003, DOI 10.1093/ACPROF:OSO/9780199586974.003]
   McMurray RG, 1998, MED SCI SPORT EXER, V30, P1521, DOI 10.1097/00005768-199810000-00009
   Mikkelsen K, 2017, MATURITAS, V106, P48, DOI 10.1016/j.maturitas.2017.09.003
   Mongraw-Chaffin ML, 2015, LANCET DIABETES ENDO, V3, P437, DOI 10.1016/S2213-8587(15)00086-8
   Motamed N, 2016, J DIABETES COMPLICAT, V30, P269, DOI 10.1016/j.jdiacomp.2015.11.019
   Peltonen JE, 2013, RESP PHYSIOL NEUROBI, V188, P102, DOI 10.1016/j.resp.2013.05.014
   Peltonen JE, 2012, RESP PHYSIOL NEUROBI, V181, P267, DOI 10.1016/j.resp.2012.04.002
   Randall WM, 2022, J NEW MUSIC RES, V51, P243, DOI 10.1080/09298215.2023.2187310
   Rehfeld K, 2022, FRONT SPORTS ACT LIV, V4, DOI 10.3389/fspor.2022.915926
   Renehan AG, 2015, NAT REV CANCER, V15, P484, DOI 10.1038/nrc3967
   Rissanen APE, 2016, PHYSIOL REP, V4, DOI 10.14814/phy2.12719
   Rissanen APE, 2015, MED SCI SPORT EXER, V47, P223, DOI 10.1249/MSS.0000000000000419
   Rzewnicki R, 2003, PUBLIC HEALTH NUTR, V6, P299, DOI 10.1079/PHN2002427
   Saarikallio S, 2012, MUSIC PERCEPT, V30, P97, DOI 10.1525/MP.2012.30.1.97
   Saarikallio SH, 2008, MUSIC SCI, V12, P291, DOI 10.1177/102986490801200206
   Schneider L, 2022, FRONT PAIN RES, V3, DOI 10.3389/fpain.2022.944181
   SHVARTZ E, 1990, AVIAT SPACE ENVIR MD, V61, P3
   Silverman MJ, 2020, COMMUNITY MENT HLT J, V56, P939, DOI 10.1007/s10597-020-00560-4
   Smith TW, 2006, CURR DIR PSYCHOL SCI, V15, P227, DOI 10.1111/j.1467-8721.2006.00441.x
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Stewart J, 2019, FRONT PSYCHOL, V10, DOI 10.3389/fpsyg.2019.01199
   Svedberg P, 2006, EUR J EPIDEMIOL, V21, P767, DOI 10.1007/s10654-006-9064-3
   Terry PC, 2020, PSYCHOL BULL, V146, P91, DOI 10.1037/bul0000216
   THAYER RE, 1994, J PERS SOC PSYCHOL, V67, P910, DOI 10.1037/0022-3514.67.5.910
   Thoma MV, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0070156
   Tikkanen E, 2018, CIRCULATION, V137, P2583, DOI [10.1161/CIRCULATIONAHA.117.032432, 10.1161/circulationaha.117.032432]
   van den Tol AJM, 2020, MUSIC SCI, V24, P78, DOI 10.1177/1029864918780186
   Van den Tol AJM, 2015, PSYCHOL MUSIC, V43, P473, DOI 10.1177/0305735613517410
   Verma S, 2017, DIAB MET SYND CLIN R, V11, P73, DOI 10.1016/j.dsx.2016.06.017
   Warner ET, 2012, AM J HEALTH BEHAV, V36, P168, DOI 10.5993/AJHB.36.2.3
   Williams PT, 2001, MED SCI SPORT EXER, V33, P754, DOI 10.1097/00005768-200105000-00012
NR 72
TC 0
Z9 0
U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 27
PY 2025
VL 20
IS 2
AR e0317607
DI 10.1371/journal.pone.0317607
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA Y9S6H
UT WOS:001435433800011
PM 40014605
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Li, YR
   Zhu, H
   Danelisen, I
AF Li, Y. Robert
   Zhu, Hong
   Danelisen, Igor
TI Role of Peroxiredoxins in Protecting Against Cardiovascular and Related
   Disorders
SO CARDIOVASCULAR TOXICOLOGY
LA English
DT Article
DE Cardiovascular disease; Diabetes; Inflammation; Metabolic syndrome;
   Oxidative stress; Peroxiredoxin; Sepsis
ID PHOSPHOLIPASE A(2) ACTIVITY; OXIDATIVE STRESS; 1-CYS PEROXIREDOXIN;
   OVEREXPRESSION; ATHEROSCLEROSIS; DEFICIENCY; ACTIVATION; ENZYME; CELLS;
   H2O2
AB Peroxiredoxin (Prx) refers to a family of thiol-dependent peroxidases that decompose hydrogen peroxide, lipid hydroperoxides, as well as peroxynitrite, and protect against oxidative and inflammatory stress. There are six mammalian Prx isozymes (Prx1-6), classified as typical 2-Cys, atypical 2-Cys, or 1-Cys Prxs based on the mechanism and the number of cysteine residues involved during catalysis. In addition to their well-established peroxide-scavenging activity, some Prxs also participate in the regulation of various cell signaling pathways. Extensive animal studies employing primarily gene knockout models provide substantial evidence supporting a critical protective role of Prxs in various disease processes involving oxidative and inflammatory stress. This review surveys recent research findings, published primarily in influential journals, on the involvement of various Prx isozymes in protecting against cardiovascular injury and related disorders, including diabetes, metabolic syndromes, and sepsis, whose pathophysiology all intimately involves oxidative stress and inflammation.
C1 [Li, Y. Robert] Campbell Univ, Jerry Wallace Sch Osteopath Med, Dept Pharmacol, Buies Creek, NC 27506 USA.
   [Zhu, Hong] Campbell Univ, Sch Osteopath Med, Dept Physiol & Pathophysiol, Buies Creek, NC 27506 USA.
   [Danelisen, Igor] Tufts Univ, Sch Med, Dept Med Educ, Boston, MA 02111 USA.
C3 Campbell University; Campbell University; Tufts University
RP Li, YR (corresponding author), Campbell Univ, Jerry Wallace Sch Osteopath Med, Dept Pharmacol, Buies Creek, NC 27506 USA.
EM yli@campbell.edu
OI Reis, AlessanRSS/0000-0001-8486-7469
CR Arkat S, 2016, FREE RADICAL BIO MED, V97, P489, DOI 10.1016/j.freeradbiomed.2016.06.019
   Bryk R, 2000, NATURE, V407, P211, DOI 10.1038/35025109
   Chatterjee S, 2011, J BIOL CHEM, V286, P11696, DOI 10.1074/jbc.M110.206623
   Chen JW, 2000, J BIOL CHEM, V275, P28421, DOI 10.1074/jbc.M005073200
   Chen LJ, 2008, AGING CELL, V7, P866, DOI 10.1111/j.1474-9726.2008.00432.x
   Choi MH, 2005, NATURE, V435, P347, DOI 10.1038/nature03587
   De Armas MI, 2019, FREE RADICAL BIO MED, V130, P369, DOI 10.1016/j.freeradbiomed.2018.10.451
   Dey S, 2018, CIRC RES, V123, P356, DOI 10.1161/CIRCRESAHA.118.312708
   Ding Y, 2010, ANTIOXID REDOX SIGN, V13, P1477, DOI 10.1089/ars.2010.3137
   Federti E, 2017, FREE RADICAL BIO MED, V112, P376, DOI 10.1016/j.freeradbiomed.2017.08.004
   Fisher AB, 2017, ARCH BIOCHEM BIOPHYS, V617, P68, DOI 10.1016/j.abb.2016.12.003
   Graham DB, 2018, CELL REP, V24, P838, DOI 10.1016/j.celrep.2018.06.081
   Guo X, 2012, ANTIOXID REDOX SIGN, V17, P1362, DOI 10.1089/ars.2012.4549
   He CY, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8770
   Hiroi M, 2011, OBESITY, V19, P882, DOI 10.1038/oby.2010.275
   Huh JY, 2012, ANTIOXID REDOX SIGN, V16, P229, DOI [10.1089/ars.2011.3952, 10.1089/ars.2010.3766]
   Jang JY, 2015, J BIOL CHEM, V290, P11432, DOI 10.1074/jbc.M115.644260
   Jeong SJ, 2018, AUTOPHAGY, V14, P120, DOI 10.1080/15548627.2017.1327942
   Kang SW, 2004, J BIOL CHEM, V279, P2535, DOI 10.1074/jbc.M307698200
   KIM KW, 1988, J BIOL CHEM, V263, P4704
   Kim MH, 2020, REDOX BIOL, V28, DOI 10.1016/j.redox.2019.101315
   Kim MH, 2019, MOL CELL BIOL, V39, DOI 10.1128/MCB.00148-19
   Kim MH, 2018, FREE RADICAL BIO MED, V123, P27, DOI 10.1016/j.freeradbiomed.2018.05.061
   Kisucka J, 2008, CIRC RES, V103, P598, DOI 10.1161/CIRCRESAHA.108.174870
   Kuda O, 2018, DIABETES, V67, P1190, DOI 10.2337/db17-1087
   Li LQ, 2007, BIOCHEM BIOPH RES CO, V355, P715, DOI 10.1016/j.bbrc.2007.02.022
   Lipinski S, 2019, EMBO J, V38, DOI 10.15252/embj.2018101266
   Manevich Y, 2002, P NATL ACAD SCI USA, V99, P11599, DOI 10.1073/pnas.182384499
   Manta B, 2009, ARCH BIOCHEM BIOPHYS, V484, P146, DOI 10.1016/j.abb.2008.11.017
   Matsushima S, 2006, CIRCULATION, V113, P1779, DOI 10.1161/CIRCULATIONAHA.105.582239
   Mehmeti I, 2014, J BIOL CHEM, V289, P26904, DOI 10.1074/jbc.M114.568329
   Nabeshima A, 2013, ANTIOXID REDOX SIGN, V19, P1983, DOI 10.1089/ars.2012.4946
   Nickel AG, 2015, CELL METAB, V22, P472, DOI 10.1016/j.cmet.2015.07.008
   Pacifici F, 2014, DIABETES, V63, P3210, DOI 10.2337/db14-0144
   Park JG, 2011, CIRC RES, V109, P739, DOI 10.1161/CIRCRESAHA.111.245530
   Phelan SA, 2003, FREE RADICAL BIO MED, V35, P1110, DOI 10.1016/S0891-5849(03)00462-3
   Salzano S, 2014, P NATL ACAD SCI USA, V111, P12157, DOI 10.1073/pnas.1401712111
   Stancill JS, 2020, AM J PHYSIOL-REG I, V318, pR1004, DOI 10.1152/ajpregu.00011.2020
   SUNDARESAN M, 1995, SCIENCE, V270, P296, DOI 10.1126/science.270.5234.296
   Syed I, 2018, CELL METAB, V27, P419, DOI 10.1016/j.cmet.2018.01.001
   Tsutsui H, 2009, CARDIOVASC RES, V81, P449, DOI 10.1093/cvr/cvn280
   Vázquez-Medina JP, 2019, AM J PHYSIOL-LUNG C, V316, pL656, DOI 10.1152/ajplung.00344.2018
   Vazquez-Medina JP, 2016, FASEB J, V30, P2885, DOI 10.1096/fj.201500146R
   Wang QM, 2010, MED SCI MONITOR, V16, pBR321
   Wang XS, 2004, ATHEROSCLEROSIS, V177, P61, DOI 10.1016/j.atherosclerosis.2004.06.007
   Yang CS, 2007, J EXP MED, V204, P583, DOI 10.1084/jem.20061849
   Yore MM, 2014, CELL, V159, P318, DOI 10.1016/j.cell.2014.09.035
NR 47
TC 15
Z9 15
U1 1
U2 4
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1530-7905
EI 1559-0259
J9 CARDIOVASC TOXICOL
JI Cardiovasc. Toxicol.
PD OCT
PY 2020
VL 20
IS 5
BP 448
EP 453
DI 10.1007/s12012-020-09588-0
EA JUL 2020
PG 6
WC Cardiac & Cardiovascular Systems; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Toxicology
GA NL6FY
UT WOS:000545933800001
PM 32632849
DA 2025-06-11
ER

PT J
AU Stephen, DS
   Abraham, A
AF Stephen, DSouza Serena
   Abraham, Asha
TI High-fat simple carbohydrate (HFSC) diet impairs hypothalamic and corpus
   striatal serotonergic metabolic pathway in metabolic syndrome (MetS)
   induced C57BL/6J mice
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Article
DE Serotonin; 5-HTP; 5-HIAA; High-Performance Liquid Chromatography;
   High-Fat Simple Carbohydrate Diet; C57BL/6J Mice; Metabolic Syndrome
ID INSULIN-RESISTANCE; DIABETES-MELLITUS; ACID; RESPONSIVITY; RECEPTORS;
   DISORDER; RELEASE; WOMEN
AB Objectives: To study the effect of specially formulated high-fat simple carbohydrate diet (HFSC) on the serotonin metabolic pathway in male C57BL/6J mice. Methods: Previous studies from our laboratory have shown that specially formulated HFSC induces metabolic syndrome in C57BL/6J mice. In the present investigation, 5-hydroxytryptophan, serotonin and 5-hydroxyindoleacetic acid were analyzed in two brain regions (hypothalamus, corpus striatum), urine and plasma of HFSC-fed mice on a monthly basis up to 5 months using high-performance liquid chromatography fitted with electrochemical detector. The data were analyzed using Graph pad Prism v7.3 by two-way ANOVA and post hoc Tukey's test (to assess the effect of time on the serotonergic metabolic pathway). Results: HFSC feed was observed to lower the hypothalamic serotonergic tone as compared to the age-matched control-fed C57BL/6J mice. Although the hypothalamic serotonergic tone was unaltered over time due to consumption of diet per se, hypothalamic 5-HTP levels were observed to be lower on consumption of HFSC feed over duration of 5 months as compared to 1st month of consumption of HFSC feed. The striatal 5-HTP levels were lowered in the HFSC-fed mice after 4 months of feeding as compared to the age-matched control-fed mice. The striatal 5-HTP levels were also lower in both control and HFSC-fed mice due to consumption of the respective diet over a duration of 5 months. Increased plasma 5-HTP levels were observed due to consumption of HFSC feed over duration of 5 months in the HFSC-fed group. However, higher breakdown of serotonin was observed in both the plasma and urine of HFSC-fed C57BL/6J mice as per the turnover studies. Discussion: The central and peripheral serotonergic pathway is affected differentially by both the type of diet consumed and the duration for which the diet is consumed. The hypothalamic, striatal and plasma serotonergic pathway were altered both by the type of feed consumed and the duration of feeding. The urine serotonergic pathway was affected by mainly the duration for which a particular diet was consumed. These findings may have implications in the feeding behavior, cognitive decline and depression associated with metabolic syndrome patients.
C1 [Stephen, DSouza Serena; Abraham, Asha] St Aloysius Autonomous Coll, Dept Postgrad Studies & Res Biotechnol, Father George Albuquerque Pai Cell & Mol Biol Lab, Mangaluru 575003, Karnataka, India.
   [Stephen, DSouza Serena] Indian Inst Technol, Dept Chem Engn, Prot Engn Lab, 125 B, Bombay 400076, Maharashtra, India.
C3 Indian Institute of Technology System (IIT System); Indian Institute of
   Technology (IIT) - Bombay
RP Abraham, A (corresponding author), St Aloysius Autonomous Coll, Dept Postgrad Studies & Res Biotechnol, Father George Albuquerque Pai Cell & Mol Biol Lab, Mangaluru 575003, Karnataka, India.
EM abraham.asha@gmail.com
RI Abraham, Asha/ABD-8580-2020
OI Abraham, Asha/0000-0002-0201-5551
FU Council of Scientific and Industrial Research [08/439(0004)/2010-EMR-1];
   University Grants Commission [39-251/2010 (SR)]
FX This work was supported by Council of Scientific and Industrial Research
   (grant number 08/439(0004)/2010-EMR-1) and University Grants Commission
   (grant number F. No. 39-251/2010 (SR)).
CR Asarian L, 2006, J NEUROSCI, V26, P11255, DOI 10.1523/JNEUROSCI.3717-06.2006
   BARRADAS MA, 1988, EUR J CLIN INVEST, V18, P399, DOI 10.1111/j.1365-2362.1988.tb01030.x
   BENLOUCIF S, 1991, EUR J PHARMACOL, V200, P1, DOI 10.1016/0014-2999(91)90658-D
   Berger M, 2009, ANNU REV MED, V60, P355, DOI 10.1146/annurev.med.60.042307.110802
   Bonhaus DW, 1997, NEUROPHARMACOLOGY, V36, P621, DOI 10.1016/S0028-3908(97)00049-X
   Breum L, 2003, AM J CLIN NUTR, V77, P1112, DOI 10.1093/ajcn/77.5.1112
   BRODERICK PA, 1988, DIABETES, V37, P956, DOI 10.2337/diabetes.37.7.956
   CHEN CC, 1991, BRAIN RES, V552, P175, DOI 10.1016/0006-8993(91)90677-N
   Chrousos GP, 1998, J CLIN ENDOCR METAB, V83, P1842, DOI 10.1210/jc.83.6.1842
   Chu PC, 1990, DIABETES, V39, P942, DOI [10.2337/diab.39.8.942, DOI 10.2337/DIAB.39.8.942]
   D'Souza S. S., 2016, Journal of Nutrition & Intermediary Metabolism, V3, P41, DOI 10.1016/j.jnim.2015.12.334
   D'Souza SS, 2016, NEUROL INDIA, V64, P923, DOI 10.4103/0028-3886.190261
   DINAN TG, 1994, BRIT J PSYCHIAT, V164, P365, DOI 10.1192/bjp.164.3.365
   DSouza S.S., 2014, IOSR J. Pharm. Biol. Sci, V9, P109, DOI [10.9790/3008-0914109113, DOI 10.9790/3008-0914109113]
   Ellacott KLJ, 2010, CELL METAB, V12, P10, DOI 10.1016/j.cmet.2010.06.001
   Fernandez-Fernandez R, 2006, MOL CELL ENDOCRINOL, V254, P127, DOI 10.1016/j.mce.2006.04.026
   Fukui M, 2012, DIABETES CARE, V35, P163, DOI 10.2337/dc11-1619
   FULLER RW, 1990, NEUROPSYCHOPHARMACOL, V3, P495
   Gerozissis K, 1997, PHYSIOL BEHAV, V62, P767, DOI 10.1016/S0031-9384(97)00195-9
   Gerozissis K, 1998, PHYSIOL BEHAV, V65, P271, DOI 10.1016/S0031-9384(98)00158-9
   Giannakopoulos G, 1998, PROG NEURO-PSYCHOPH, V22, P803, DOI 10.1016/S0278-5846(98)00041-4
   Herrera-Marquez R, 2011, METAB BRAIN DIS, V26, P29, DOI 10.1007/s11011-010-9229-3
   Hill JW, 2008, AM J PHYSIOL-ENDOC M, V294, pE827, DOI 10.1152/ajpendo.00670.2007
   Hinz M, 2012, NEUROPSYCH DIS TREAT, V8, P323, DOI 10.2147/NDT.S33259
   Indian National Science Academy, 2000, GUID CAR US AN SCI R
   Kim M, 2013, BIOMOL THER, V21, P476, DOI 10.4062/biomolther.2013.063
   Kirac D, 2009, NUTR NEUROSCI, V12, P89, DOI 10.1179/147683009X423256
   MANN JJ, 1992, ARCH GEN PSYCHIAT, V49, P442
   MCCALEB ML, 1982, BRAIN RES BULL, V8, P325, DOI 10.1016/0361-9230(82)90066-1
   Muldoon MF, 2006, J CLIN ENDOCR METAB, V91, P718, DOI 10.1210/jc.2005-1654
   Muldoon MF, 2004, J CLIN ENDOCR METAB, V89, P266, DOI 10.1210/jc.2003-031295
   Nakatani Y, 2008, EUR J NEUROSCI, V27, P2466, DOI 10.1111/j.1460-9568.2008.06201.x
   Navailles S, 2011, PSYCHOPHARMACOLOGY, V213, P213, DOI 10.1007/s00213-010-2029-y
   Papazoglou I, 2012, MOL CELL ENDOCRINOL, V350, P136, DOI 10.1016/j.mce.2011.12.007
   PAULOSE CS, 1988, HYPERTENSION, V11, P387, DOI 10.1161/01.HYP.11.4.387
   Popa M, 1989, Endocrinologie, V27, P29
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Ramage AG, 2001, BRAIN RES BULL, V56, P425, DOI 10.1016/S0361-9230(01)00612-8
   Ramasubbu R, 2002, MED HYPOTHESES, V59, P537, DOI 10.1016/S0306-9877(02)00244-X
   Swarnalatha BN, 2016, ENDOKRYNOL POL, V67, P592, DOI 10.5603/EP.2016.0069
   Tarantino G, 2011, INT J IMMUNOPATH PH, V24, P769, DOI 10.1177/039463201102400323
   TECOTT LH, 1995, NATURE, V374, P542, DOI 10.1038/374542a0
   Tiefenbacher S, 2004, PSYCHONEUROENDOCRINO, V29, P501, DOI 10.1016/S0306-4530(03)00068-4
   Vickers SP, 1999, PSYCHOPHARMACOLOGY, V143, P309, DOI 10.1007/s002130050952
   Walther DJ, 2003, SCIENCE, V299, P76, DOI 10.1126/science.1078197
NR 45
TC 4
Z9 4
U1 0
U2 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1028-415X
EI 1476-8305
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PD JAN 2
PY 2019
VL 22
IS 1
BP 51
EP 62
DI 10.1080/1028415X.2017.1354511
PG 12
WC Neurosciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Nutrition & Dietetics
GA HC5DK
UT WOS:000451823500005
PM 28745143
DA 2025-06-11
ER

PT J
AU Park, HJ
   Bruno, RS
AF Park, Hea Jin
   Bruno, Richard S.
TI Hepatoprotective activities of green tea in nonalcoholic fatty liver
   disease
SO AGRO FOOD INDUSTRY HI-TECH
LA English
DT Article
DE green tea; nonalcoholic fatty liver disease; catechins; oxidative stress
ID METABOLIC SYNDROME; EPIGALLOCATECHIN GALLATE; CATECHIN-POLYPHENOLS;
   INSULIN-RESISTANCE; HEPATIC STEATOSIS; ANTIOXIDANT; EXTRACT; EXPRESSION;
   (-)-EPIGALLOCATECHIN-3-GALLATE; CONSUMPTION
AB Nonalcoholic fatty liver disease (NAFLD) is a constellation of asymptomatic liver diseases that increase liver-related morbidity and modality risk. The development of NAFLD is attributed to obesity and insulin resistance that cause excess hepatic lipid accumulation and increase the vulnerability of the liver to hepatotoxic insults such as oxidative stress and inflammatory responses. Accumulating evidence demonstrates that green tea, likely through its catechins, exerts hypolipidemic, antioxidant and anti-inflammatory activities, making it an ideal candidate functional food for preventing and/or managing NAFLD. Thus, this review will describe the multi-faceted hepatoprotective activities of green tea on the pathogenic events leading to NAFLD.
C1 [Park, Hea Jin; Bruno, Richard S.] Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
C3 University of Connecticut
RP Bruno, RS (corresponding author), Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
RI Bruno, Richard/K-1930-2012
OI Bruno, Richard/0000-0002-6772-2038
FU USDA National Institute for Food and Agriculture [2007-02303];
   USDA-HATCH [CONS00802]
FX This project was supported by grants to RSB from the National Research
   Initiative Grant 2007-02303 from the USDA National Institute for Food
   and Agriculture as well as the USDA-HATCH (CONS00802) program. We also
   wish to thank Kevin Noonan for assistance with the artwork.
CR Angulo P, 2002, NEW ENGL J MED, V346, P1221, DOI 10.1038/nrdp.2015.80
   Ashida H, 2004, BIOFACTORS, V22, P135, DOI 10.1002/biof.5520220126
   Bose M, 2008, J NUTR, V138, P1677, DOI 10.1093/jn/138.9.1677
   Browning JD, 2004, J CLIN INVEST, V114, P147, DOI 10.1172/JCI200422422
   Bruno RS, 2008, J NUTR, V138, P323, DOI 10.1093/jn/138.2.323
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   Diehl AM, 2002, AM J PHYSIOL-GASTR L, V282, pG1, DOI 10.1152/ajpgi.00384.2001
   Dulloo AG, 2000, INT J OBESITY, V24, P252, DOI 10.1038/sj.ijo.0801101
   Dulloo AG, 1999, AM J CLIN NUTR, V70, P1040
   Frei B, 2003, J NUTR, V133, p3275S, DOI 10.1093/jn/133.10.3275S
   Higdon JV, 2003, CRIT REV FOOD SCI, V43, P89, DOI 10.1080/10408690390826464
   IMAI K, 1995, BRIT MED J, V310, P693, DOI 10.1136/bmj.310.6981.693
   Kim HJ, 2009, PHYTOTHER RES, V23, P467, DOI 10.1002/ptr.2647
   Kim Jeong-A., 2008, Endocrine Metabolic & Immune Disorders-Drug Targets, V8, P82, DOI 10.2174/187153008784534349
   Koo SI, 2007, J NUTR BIOCHEM, V18, P179, DOI 10.1016/j.jnutbio.2006.12.005
   Kuriyama S, 2006, JAMA-J AM MED ASSOC, V296, P1255, DOI 10.1001/jama.296.10.1255
   Lee MS, 2009, ANN NUTR METAB, V54, P151, DOI 10.1159/000214834
   Na HK, 2008, FOOD CHEM TOXICOL, V46, P1271, DOI 10.1016/j.fct.2007.10.006
   Raederstorff DG, 2003, J NUTR BIOCHEM, V14, P326, DOI 10.1016/S0955-2863(03)00054-8
   Ryu OH, 2006, DIABETES RES CLIN PR, V71, P356, DOI 10.1016/j.diabres.2005.08.001
   Shrestha S, 2009, J NUTR, V139, P640, DOI 10.3945/jn.108.103341
   Soory Mena, 2009, Infectious Disorders - Drug Targets, V9, P400
   Tedeschi E, 2004, MOL PHARMACOL, V65, P111, DOI 10.1124/mol.65.1.111
   Thielecke F, 2009, PHYTOCHEMISTRY, V70, P11, DOI 10.1016/j.phytochem.2008.11.011
   Tipoe George L., 2007, Cardiovascular & Hematological Disorders - Drug Targets, V7, P135
   Waltner-Law ME, 2002, J BIOL CHEM, V277, P34933, DOI 10.1074/jbc.M204672200
   Wolfram S, 2006, MOL NUTR FOOD RES, V50, P176, DOI 10.1002/mnfr.200500102
   Wu LY, 2004, J AGR FOOD CHEM, V52, P643, DOI 10.1021/jf030365d
   Yee WL, 2002, MOL CELL BIOCHEM, V229, P85, DOI 10.1023/A:1017920527201
   Yuan JH, 2008, MOL MED, V14, P590, DOI 10.2119/2007-00050.Yuan
NR 30
TC 5
Z9 6
U1 0
U2 5
PU TEKNOSCIENZE PUBL
PI MILANO
PA VIALE BRIANZA 22, 20127 MILANO, ITALY
SN 1722-6996
EI 2035-4606
J9 AGRO FOOD IND HI TEC
JI Agro Food Ind. Hi-Tech
PD JAN-FEB
PY 2010
VL 21
IS 1
BP 37
EP 40
PG 4
WC Biotechnology & Applied Microbiology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Food Science & Technology
GA 570DN
UT WOS:000275652000010
DA 2025-06-11
ER

PT J
AU Padmanabhan, V
   Cardoso, RC
   Puttabyatappa, M
AF Padmanabhan, Vasantha
   Cardoso, Rodolfo C.
   Puttabyatappa, Muraly
TI Developmental Programming, a Pathway to Disease
SO ENDOCRINOLOGY
LA English
DT Review
ID POLYCYSTIC-OVARY-SYNDROME; HIGH-FAT DIET; INTRAUTERINE
   GROWTH-RETARDATION; BODY-MASS INDEX; MATERNAL OBESITY; PRENATAL STRESS;
   POLYCHLORINATED-BIPHENYLS; FETAL ORIGINS; LIFE-STYLE; METABOLIC SYNDROME
AB Accumulating evidence suggests that insults occurring during the perinatal period alter the developmental trajectory of the fetus/offspring leading to long-term detrimental outcomes that often culminate in adult pathologies. These perinatal insults include maternal/fetal disease states, nutritional deficits/excess, stress, lifestyle choices, exposure to environmental chemicals, and medical interventions. In addition to reviewing the various insults that contribute to developmental programming and the benefits of animal models in addressing underlying mechanisms, this review focuses on the commonalities in disease outcomes stemming from various insults, the convergence of mechanistic pathways via which various insults can lead to common outcomes, and identifies the knowledge gaps in the field and future directions.
C1 [Padmanabhan, Vasantha; Cardoso, Rodolfo C.; Puttabyatappa, Muraly] Univ Michigan, Dept Pediat, 1150 West Med Ctr Dr,7510 MSRB 1, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan
RP Padmanabhan, V (corresponding author), Univ Michigan, Dept Pediat, 1150 West Med Ctr Dr,7510 MSRB 1, Ann Arbor, MI 48109 USA.
EM vasantha@umich.edu
RI Puttabyatappa, Muraly/K-2598-2015; Padmanabhan, Vasantha/C-8558-2017
OI Cardoso, Rodolfo/0000-0002-2466-5205; Padmanabhan,
   Vasantha/0000-0002-8443-7212
FU National Institutes of Health [P01 HD44232]; National Institute of
   Diabetes and Digestive and Kidney Diseases [P30DK020572] Funding Source:
   NIH RePORTER
FX This work was supported by National Institutes of Health Grant P01
   HD44232.
CR Abbott DH, 2013, MOL CELL ENDOCRINOL, V373, P21, DOI 10.1016/j.mce.2013.01.013
   Aerts L, 2006, INT J BIOCHEM CELL B, V38, P894, DOI 10.1016/j.biocel.2005.07.006
   Ainge H, 2011, INT J OBESITY, V35, P325, DOI 10.1038/ijo.2010.149
   Alfaradhi Maria Z., 2011, Frontiers in Genetics, V2, P27, DOI 10.3389/fgene.2011.00027
   ANDO M, 1985, ARCH ENVIRON CON TOX, V14, P51, DOI 10.1007/BF01055761
   [Anonymous], END DISR
   Armitage JA, 2005, J PHYSIOL-LONDON, V565, P3, DOI 10.1113/jphysiol.2004.079756
   Armitage JA, 2004, J PHYSIOL-LONDON, V561, P355, DOI 10.1113/jphysiol.2004.072009
   Bahrke MS, 1998, CHILD ADOL PSYCH CL, V7, P821, DOI 10.1016/S1056-4993(18)30214-1
   Bale TL, 2014, DIALOGUES CLIN NEURO, V16, P297
   Bar-Lev A, 2012, CURR OPIN ENDOCRINOL, V19, P159, DOI 10.1097/MED.0b013e328352f013
   Barbour LA, 2014, CURR OPIN ENDOCRINOL, V21, P264, DOI 10.1097/MED.0000000000000080
   Barker DJP, 2007, J INTERN MED, V261, P412, DOI 10.1111/j.1365-2796.2007.01809.x
   Barker DJP, 2011, AM J HUM BIOL, V23, P412, DOI 10.1002/ajhb.21165
   Barker DJP, 2004, J AM COLL NUTR, V23, p588S, DOI 10.1080/07315724.2004.10719428
   BARKER DJP, 1995, BRIT MED J, V311, P171, DOI 10.1136/bmj.311.6998.171
   Barker DJP, 2002, INT J EPIDEMIOL, V31, P1235, DOI 10.1093/ije/31.6.1235
   BARKER DJP, 1988, BRIT MED J, V297, P134, DOI 10.1136/bmj.297.6641.134-b
   Barnes AS, 2012, TEX HEART I J, V39, P224
   BARNES RB, 1994, J CLIN ENDOCR METAB, V79, P1328, DOI 10.1210/jc.79.5.1328
   Barrett ES, 2015, ENDOCRINOLOGY, V156, P3435, DOI 10.1210/en.2015-1335
   Barua S, 2015, EPIGENOMICS-UK, V7, P85, DOI [10.2217/EPI.14.71, 10.2217/epi.14.71]
   Bayer TA, 1999, J PSYCHIATR RES, V33, P543, DOI 10.1016/S0022-3956(99)00039-4
   Baz B, 2016, EUR J ENDOCRINOL, V174, pR43, DOI 10.1530/EJE-15-0378
   Beckett EM, 2014, REPRODUCTION, V148, P199, DOI 10.1530/REP-14-0055
   Beijers R, 2014, EUR CHILD ADOLES PSY, V23, P943, DOI 10.1007/s00787-014-0566-3
   Belkacemi L, 2010, BIOL REPROD, V83, P325, DOI 10.1095/biolreprod.110.084517
   Bell MR, 2016, MOL CELL ENDOCRINOL, V420, P125, DOI 10.1016/j.mce.2015.11.024
   Berends LM, 2012, BEST PRACT RES CL EN, V26, P569, DOI 10.1016/j.beem.2012.03.002
   Bispham J, 2003, ENDOCRINOLOGY, V144, P3575, DOI 10.1210/en.2003-0320
   Bondesson M, 2015, BBA-GENE REGUL MECH, V1849, P142, DOI 10.1016/j.bbagrm.2014.06.005
   Bouchard L, 2010, DIABETES CARE, V33, P2436, DOI 10.2337/dc10-1024
   Bouret SG, 2004, J NEUROSCI, V24, P2797, DOI 10.1523/JNEUROSCI.5369-03.2004
   Braun K, 2014, J NEUROENDOCRINOL, V26, P697, DOI 10.1111/jne.12174
   Bruce KD, 2009, HEPATOLOGY, V50, P1796, DOI 10.1002/hep.23205
   Capra L, 2013, ITAL J PEDIATR, V39, DOI 10.1186/1824-7288-39-7
   Cardoso RC, 2016, ENDOCRINOLOGY, V157, P522, DOI 10.1210/en.2015-1565
   Cardoso RC, 2015, NEUROENDOCRINOLOGY, V102, P226, DOI 10.1159/000381830
   Catalano PM, 2006, BJOG-INT J OBSTET GY, V113, P1126, DOI 10.1111/j.1471-0528.2006.00989.x
   Chen C, 2010, MINERVA ENDOCRINOL, V35, P271
   Chevalier N, 2015, DIABETES METAB, V41, P107, DOI 10.1016/j.diabet.2014.09.005
   Constantinof A, 2016, J STEROID BIOCHEM, V160, P175, DOI 10.1016/j.jsbmb.2015.10.008
   Corbould A, 2008, DIABETES-METAB RES, V24, P520, DOI 10.1002/dmrr.872
   Coviello AD, 2006, J CLIN ENDOCR METAB, V91, P492, DOI 10.1210/jc.2005-1666
   Crews D, 2007, P NATL ACAD SCI USA, V104, P5942, DOI 10.1073/pnas.0610410104
   Curley JP, 2011, HORM BEHAV, V59, P306, DOI 10.1016/j.yhbeh.2010.06.018
   Dahlen HG, 2013, MED HYPOTHESES, V80, P656, DOI 10.1016/j.mehy.2013.01.017
   Davis EF, 2012, CLIN SCI, V123, P53, DOI 10.1042/CS20110627
   Davis JC, 2014, BRIT J SPORT MED, V48, P947, DOI 10.1136/bjsports-2014-093575
   De Geyter C, 2006, HUM REPROD, V21, P705, DOI 10.1093/humrep/dei378
   De Rycke M, 2002, HUM REPROD, V17, P2487, DOI 10.1093/humrep/17.10.2487
   Diamanti-Kandarakis E, 2009, ENDOCR REV, V30, P293, DOI 10.1210/er.2009-0002
   Dixon B, 2012, ADV NUTR, V3, P73, DOI 10.3945/an.111.000919
   Dolinoy DC, 2007, P NATL ACAD SCI USA, V104, P13056, DOI 10.1073/pnas.0703739104
   Dumesic DA, 2014, SEMIN REPROD MED, V32, P159, DOI 10.1055/s-0034-1371087
   Entringer S, 2015, PSYCHONEUROENDOCRINO, V62, P366, DOI 10.1016/j.psyneuen.2015.08.019
   Entringer S, 2013, CURR OPIN CLIN NUTR, V16, P320, DOI 10.1097/MCO.0b013e32835e8d80
   Finnell RH, 2002, ANNU REV PHARMACOL, V42, P181, DOI 10.1146/annurev.pharmtox.42.083001.110955
   Fisher SC, 2013, PREV MED, V56, P372, DOI 10.1016/j.ypmed.2013.02.015
   Flegal KM, 2010, JAMA-J AM MED ASSOC, V303, P235, DOI 10.1001/jama.2009.2014
   FOREST MG, 1983, HORM RES, V18, P69, DOI 10.1159/000179780
   Forhead AJ, 2009, J PHYSIOL-LONDON, V587, P1145, DOI 10.1113/jphysiol.2008.167072
   Fowden AL, 2004, REPRODUCTION, V127, P515, DOI 10.1530/rep.1.00033
   Fowden AL, 2003, PLACENTA, V24, P803, DOI 10.1016/S0143-4004(03)00080-8
   Ganie MA, 2013, J CLIN ENDOCR METAB, V98, P3599, DOI 10.1210/jc.2013-1040
   Ganu R S, 2012, Int J Obes Suppl, V2, pS14
   Gardner DS, 2005, AM J PHYSIOL-REG I, V289, pR947, DOI 10.1152/ajpregu.00120.2005
   Giraudo SQ, 2010, PHARMACOL BIOCHEM BE, V97, P121, DOI 10.1016/j.pbb.2010.04.017
   Gluckman PD, 2004, PEDIATR RES, V56, P311, DOI 10.1203/01.PDR.0000135998.08025.FB
   Gluckman Peter D, 2004, Semin Fetal Neonatal Med, V9, P419, DOI 10.1016/j.siny.2004.03.001
   Godfrey KM, 2007, PEDIATR RES, V61, p5R, DOI 10.1203/pdr.0b013e318045bedb
   Gore AC, 2015, ENDOCR REV, V36, pE1, DOI 10.1210/er.2015-1010
   Gorski JN, 2006, AM J PHYSIOL-REG I, V291, pR768, DOI 10.1152/ajpregu.00138.2006
   Gorski R A, 1985, J Anim Sci, V61 Suppl 3, P38
   GRAY PH, 1963, J GEN PSYCHOL, V68, P333, DOI 10.1080/00221309.1963.9920539
   Guo YLL, 2004, INT ARCH OCC ENV HEA, V77, P153, DOI 10.1007/s00420-003-0487-9
   Hales CN, 2001, BRIT MED BULL, V60, P5, DOI 10.1093/bmb/60.1.5
   HARADA M, 1995, CRIT REV TOXICOL, V25, P1, DOI 10.3109/10408449509089885
   Harville E, 2010, OBSTET GYNECOL SURV, V65, P713, DOI 10.1097/OGX.0b013e31820eddbe
   Heerwagen MJR, 2010, AM J PHYSIOL-REG I, V299, pR711, DOI 10.1152/ajpregu.00310.2010
   Hiort O, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-152
   Holemans K, 2004, AM J OBSTET GYNECOL, V190, P858, DOI 10.1016/j.ajog.2003.09.025
   Huizink AC, 2004, PSYCHOL BULL, V130, P115, DOI 10.1037/0033-2909.130.1.115
   Ibáñez L, 1998, J CLIN ENDOCR METAB, V83, P3558, DOI 10.1210/jc.83.10.3558
   Ibáñez L, 2003, HUM REPROD, V18, P57, DOI 10.1093/humrep/deg056
   Isaksen CV, 2004, PEDIATR DEVEL PATHOL, V7, P433, DOI 10.1007/s10024-004-0105-1
   Ji Y, 2016, J NUTR BIOCHEM, V27, P1, DOI 10.1016/j.jnutbio.2015.08.003
   Jirtle RL, 2007, NAT REV GENET, V8, P253, DOI 10.1038/nrg2045
   JOST A, 1983, PSYCHONEUROENDOCRINO, V8, P183, DOI 10.1016/0306-4530(83)90055-0
   Kabir ER, 2015, ENVIRON TOXICOL PHAR, V40, P241, DOI 10.1016/j.etap.2015.06.009
   Kaplan JL, 2011, PEDIATR RES, V69, P465, DOI 10.1203/PDR.0b013e318217638a
   Keinan-Boker L, 2015, ISR MED ASSOC J, V17, P206
   Khan IY, 2005, AM J PHYSIOL-REG I, V288, pR127, DOI 10.1152/ajpregu.00354.2004
   Koletzko B, 2014, ANN NUTR METAB, V64, P187, DOI 10.1159/000365017
   Kral JG, 2006, PEDIATRICS, V118, pE1644, DOI 10.1542/peds.2006-1379
   Kwong WY, 2000, DEVELOPMENT, V127, P4195
   Laitinen J, 2001, AM J CLIN NUTR, V74, P287
   Lake JK, 1997, ARCH DIS CHILD, V77, P376, DOI 10.1136/adc.77.5.376
   Lakshmy R, 2013, REV ENDOCR METAB DIS, V14, P229, DOI 10.1007/s11154-013-9266-4
   Lal MK, 2003, PEDIATRICS, V111, P483, DOI 10.1542/peds.111.3.483
   Lane RH, 2014, CLIN PERINATOL, V41, P815, DOI 10.1016/j.clp.2014.08.006
   Lau EY, 2014, J OBES, V2014, DOI 10.1155/2014/524939
   Lawlor DA, 2012, NAT REV ENDOCRINOL, V8, P679, DOI 10.1038/nrendo.2012.176
   Lecoutre S, 2015, FRONT PHYSIOL, P6158
   Lesage J, 2004, J ENDOCRINOL, V181, P291, DOI 10.1677/joe.0.1810291
   Lesage J, 2002, J ENDOCRINOL, V174, DOI 10.1677/joe.0.1740037
   Li JO, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011896
   Long NM, 2010, J ANIM SCI, V88, P3546, DOI 10.2527/jas.2010-3083
   Long NM, 2010, J ANIM SCI, V88, P2029, DOI 10.2527/jas.2009-2568
   Long NM, 2013, REPROD BIOL ENDOCRIN, V11, DOI 10.1186/1477-7827-11-34
   LUCAS A, 1991, CIBA F SYMP, V156, P38
   Luo ZC, 2006, MED HYPOTHESES, V66, P38, DOI 10.1016/j.mehy.2005.08.020
   Mairesse J, 2007, AM J PHYSIOL-ENDOC M, V292, pE1526, DOI 10.1152/ajpendo.00574.2006
   Manco M, 2012, FRONT CELL INFECT MI, V2, DOI 10.3389/fcimb.2012.00109
   MASUDA Y, 1978, FOOD COSMET TOXICOL, V16, P543, DOI 10.1016/S0015-6264(78)80221-1
   Mathias PCF, 2014, EUR J NUTR, V53, P711, DOI 10.1007/s00394-014-0654-7
   Matthews SG, 2002, TRENDS ENDOCRIN MET, V13, P373, DOI 10.1016/S1043-2760(02)00690-2
   McCurdy CE, 2009, J CLIN INVEST, V119, P323, DOI 10.1172/JCI32661
   Melo AS, 2010, HUM REPROD, V25, P2124, DOI 10.1093/humrep/deq162
   Mennitti LV, 2015, J NUTR BIOCHEM, V26, P99, DOI 10.1016/j.jnutbio.2014.10.001
   Moisiadis VG, 2014, NAT REV ENDOCRINOL, V10, P391, DOI 10.1038/nrendo.2014.73
   Mourtakos SP, 2015, BMC PREGNANCY CHILDB, V15, DOI 10.1186/s12884-015-0498-z
   Nakae J, 2001, ENDOCR REV, V22, P818, DOI 10.1210/edrv.22.6.0452
   Nathanielsz PW, 2013, NUTR REV, V71, pS78, DOI 10.1111/nure.12062
   National Center for Chronic Disease Prevention and Health Promotion Centers for Disease Control and Prevention, 2013, 2013 ASS REPR TECHN
   Neier Kari, 2015, Endocr Disruptors (Austin), V3
   Ng SF, 2010, NATURE, V467, P963, DOI 10.1038/nature09491
   O'Reilly JR, 2013, CLIN ENDOCRINOL, V78, P9, DOI 10.1111/cen.12055
   Owen N, 2010, MAYO CLIN PROC, V85, P1138, DOI 10.4065/mcp.2010.0444
   Padmanabhan V, 2010, ENDOCRINOLOGY, V151, P595, DOI 10.1210/en.2009-1015
   Padmanabhan V, 2013, STEROIDS, V78, P734, DOI 10.1016/j.steroids.2013.05.004
   Padmanabhan V, 2013, MOL CELL ENDOCRINOL, V373, P8, DOI 10.1016/j.mce.2012.10.005
   Painter RC, 2008, BJOG-INT J OBSTET GY, V115, P1243, DOI 10.1111/j.1471-0528.2008.01822.x
   Palatianou ME, 2014, HORM METAB RES, V46, P911, DOI 10.1055/s-0034-1395561
   Paliy O, 2014, NUTRITION, V30, P245, DOI 10.1016/j.nut.2013.05.011
   Park JH, 2008, J CLIN INVEST, V118, P2316, DOI [10.1172/JC133655, 10.1172/JCI33655]
   Pasquali R, 2006, EUR J ENDOCRINOL, V154, P763, DOI 10.1530/eje.1.02156
   Pembrey ME, 2010, HUM FERTIL, V13, P268, DOI 10.3109/14647273.2010.524721
   Perera F, 2011, REPROD TOXICOL, V31, P363, DOI 10.1016/j.reprotox.2010.12.055
   Peretz J, 2014, ENVIRON HEALTH PERSP, V122, P775, DOI 10.1289/ehp.1307728
   PHOENIX CH, 1959, ENDOCRINOLOGY, V65, P369, DOI 10.1210/endo-65-3-369
   Poston L, 2010, BEST PRACT RES CL EN, V24, P541, DOI 10.1016/j.beem.2010.05.007
   Puttabyatappa M, 2016, MOL CELL ENDOCRINOL, V435, P29, DOI 10.1016/j.mce.2015.11.030
   Radaelli T, 2003, DIABETES, V52, P2951, DOI 10.2337/diabetes.52.12.2951
   Rattanatray L, 2010, ENDOCRINOLOGY, V151, P5195, DOI 10.1210/en.2010-0501
   Ravelli ACJ, 1999, AM J CLIN NUTR, V70, P811
   Ravelli ACJ, 1998, LANCET, V351, P173, DOI 10.1016/S0140-6736(97)07244-9
   RAVELLI GP, 1976, NEW ENGL J MED, V295, P349, DOI 10.1056/NEJM197608122950701
   Rissman EF, 2014, ENDOCRINOLOGY, V155, P2770, DOI 10.1210/en.2014-1123
   Romundstad LB, 2008, LANCET, V372, P737, DOI 10.1016/S0140-6736(08)61041-7
   Roseboom TJ, 2001, MOL CELL ENDOCRINOL, V185, P93, DOI 10.1016/S0303-7207(01)00721-3
   Ross EJ, 2015, NEUROPSYCHOPHARMACOL, V40, P61, DOI 10.1038/npp.2014.147
   Saal FSV, 2012, MOL CELL ENDOCRINOL, V354, P74, DOI 10.1016/j.mce.2012.01.001
   Salloum BA, 2015, ENDOCRINOLOGY, V156, P2323, DOI 10.1210/en.2014-2006
   Schetter CD, 2011, ANNU REV PSYCHOL, V62, P531, DOI 10.1146/annurev.psych.031809.130727
   Schneider ML, 2011, NEUROPSYCHOL REV, V21, P186, DOI 10.1007/s11065-011-9168-8
   Sen S, 2010, DIABETES, V59, P3058, DOI 10.2337/db10-0301
   SILVERMAN BL, 1993, ANN NY ACAD SCI, V699, P36, DOI 10.1111/j.1749-6632.1993.tb18835.x
   Simmons RA, 2001, DIABETES, V50, P2279, DOI 10.2337/diabetes.50.10.2279
   Sir-Petermann T, 2005, HUM REPROD, V20, P2122, DOI 10.1093/humrep/dei009
   Sir-Petermann T, 2007, J CLIN ENDOCR METAB, V92, P4637, DOI 10.1210/jc.2007-1036
   Sir-Petermann T, 2009, J CLIN ENDOCR METAB, V94, P1923, DOI 10.1210/jc.2008-2836
   Sjöblom C, 2005, ENDOCRINOLOGY, V146, P2142, DOI 10.1210/en.2004-1260
   Skinner MK, 2008, REPROD TOXICOL, V25, P2, DOI 10.1016/j.reprotox.2007.09.001
   Slotkin TA, 2004, TOXICOL APPL PHARM, V198, P132, DOI 10.1016/j.taap.2003.06.001
   SMITHELLS RW, 1981, DEV MED CHILD NEUROL, V23, P369
   Steegers EAP, 2010, LANCET, V376, P631, DOI 10.1016/S0140-6736(10)60279-6
   Stel J, 2015, ENDOCRINOLOGY, V156, P3466, DOI 10.1210/en.2015-1434
   Sullivan EL, 2010, J NEUROSCI, V30, P3826, DOI 10.1523/JNEUROSCI.5560-09.2010
   Symonds ME, 2003, J ENDOCRINOL, V179, P293, DOI 10.1677/joe.0.1790293
   Symonds ME, 2009, NAT REV ENDOCRINOL, V5, P604, DOI 10.1038/nrendo.2009.195
   Takahashi LK, 1998, PSYCHONEUROENDOCRINO, V23, P571
   Tang WY, 2007, REV ENDOCR METAB DIS, V8, P173, DOI 10.1007/s11154-007-9042-4
   Tarrade A, 2015, J EXP BIOL, V218, P50, DOI 10.1242/jeb.110320
   Tempfer CB, 2004, PHARMACOGENOMICS, V5, P57, DOI 10.1517/phgs.5.1.57.25687
   Thompson AL, 2012, AM J HUM BIOL, V24, P350, DOI 10.1002/ajhb.22254
   Thorp AA, 2010, DIABETES CARE, V33, P327, DOI 10.2337/dc09-0493
   Ting JW, 2006, PHARMACOL THERAPEUT, V111, P346, DOI 10.1016/j.pharmthera.2005.10.004
   Treviño LS, 2015, PROG BIOPHYS MOL BIO, V118, P8, DOI 10.1016/j.pbiomolbio.2015.02.013
   Vaiserman AM, 2015, DEV DYNAM, V244, P254, DOI 10.1002/dvdy.24211
   Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
   Veiga-Lopez A, 2011, BIOL REPROD, V84, P87, DOI 10.1095/biolreprod.110.086686
   Veru F, 2014, STRESS, V17, P133, DOI 10.3109/10253890.2013.876404
   Vickers MH, 2012, FRONT PHYSIOL, V3, DOI 10.3389/fphys.2012.00242
   Villamor E, 2006, LANCET, V368, P1164, DOI 10.1016/S0140-6736(06)69473-7
   Walker DM, 2011, NAT REV ENDOCRINOL, V7, P197, DOI 10.1038/nrendo.2010.215
   Weinstock M, 1997, NEUROSCI BIOBEHAV R, V21, P1, DOI 10.1016/S0149-7634(96)00014-0
   Welberg LAM, 2005, J ENDOCRINOL, V186, pR7, DOI 10.1677/joe.1.06374
   Welberg LAM, 2001, J NEUROENDOCRINOL, V13, P113, DOI 10.1046/j.1365-2826.2001.00601.x
   West-Eberhard MJ, 2005, P NATL ACAD SCI USA, V102, P6543, DOI 10.1073/pnas.0501844102
   Whyte JJ, 2007, J ENDOCRINOL, V192, P75, DOI 10.1677/JOE-06-0095
   Wood CE, 2014, ADV EXP MED BIOL, V814, P217, DOI 10.1007/978-1-4939-1031-1_19
   Wood RI, 1998, REV REPROD, V3, P130, DOI 10.1530/ror.0.0030130
   Woodruff TJ, 2011, J STEROID BIOCHEM, V127, P108, DOI 10.1016/j.jsbmb.2010.11.007
   Xin F, 2015, SEMIN CELL DEV BIOL, V43, P66, DOI 10.1016/j.semcdb.2015.05.008
   Xita N, 2010, ANN NY ACAD SCI, V1205, P148, DOI 10.1111/j.1749-6632.2010.05658.x
   Xu N, 2014, MOL ENDOCRINOL, V28, P1329, DOI 10.1210/me.2014-1042
   Yan X, 2010, ENDOCRINOLOGY, V151, P380, DOI 10.1210/en.2009-0849
   Zambrano E, 2013, NUTR REV, V71, pS42, DOI 10.1111/nure.12068
   Zuhan E, 2005, J ENDOCRINOL INVEST, V28, P49, DOI 10.1007/BF03345529
NR 200
TC 171
Z9 180
U1 0
U2 25
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD APR
PY 2016
VL 157
IS 4
BP 1328
EP 1340
DI 10.1210/en.2016-1003
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA DK0CK
UT WOS:000374579800004
PM 26859334
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Palkina, KA
   Ipatova, DA
   Shakhova, ES
   Balakireva, AV
   Markina, NM
AF Palkina, Kseniia A.
   Ipatova, Daria A.
   Shakhova, Ekaterina S.
   Balakireva, Anastasia V.
   Markina, Nadezhda M.
TI Therapeutic Potential of Hispidin-Fungal and Plant Polyketide
SO JOURNAL OF FUNGI
LA English
DT Review
DE hispidin; polyketides; antioxidant; therapeutic potential
ID PHELLINUS-LINTEUS PROTECTS; ADVANCED GLYCATION ENDPRODUCTS; PHOSPHATASE
   1B INHIBITORS; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; MEDICINAL
   FUNGI; ANTIOXIDANT HISPIDIN; SIGNAL-TRANSDUCTION; MYCELIAL CULTURES;
   SKELETAL-MUSCLE
AB There is a large number of bioactive polyketides well-known for their anticancer, antibiotic, cholesterol-lowering, and other therapeutic functions, and hispidin is among them. It is a highly abundant secondary plant and fungal metabolite, which is investigated in research devoted to cancer, metabolic syndrome, cardiovascular, neurodegenerative, and viral diseases. This review summarizes over 20 years of hispidin studies of its antioxidant, anti-inflammatory, anti-apoptotic, antiviral, and anti-cancer cell activity.
C1 [Palkina, Kseniia A.; Ipatova, Daria A.; Shakhova, Ekaterina S.; Balakireva, Anastasia V.; Markina, Nadezhda M.] Russian Acad Sci, Dept Biomol Chem, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia.
   [Palkina, Kseniia A.; Shakhova, Ekaterina S.; Balakireva, Anastasia V.; Markina, Nadezhda M.] Planta LLC, Moscow 121205, Russia.
   [Ipatova, Daria A.] Pirogov Russian Natl Res Med Univ, Sch Pharm, Fac Biomed, Moscow 117997, Russia.
C3 Russian Academy of Sciences; Pushchino Scientific Center for Biological
   Research (PSCBI) of the Russian Academy of Sciences; Institute of
   Bioorganic Chemistry of the Russian Academy of Sciences; Pirogov Russian
   National Research Medical University
RP Markina, NM (corresponding author), Russian Acad Sci, Dept Biomol Chem, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia.; Markina, NM (corresponding author), Planta LLC, Moscow 121205, Russia.
EM ksenia.palkina@planta.bio; ipatova.daria@yandex.ru;
   ekaterina.shakhova@planta.bio; anastasia@planta.bio;
   nadya.markina@planta.bio
RI Markina, Nadezhda/AAH-4379-2021; Palkina, Kseniia/AAH-4811-2020;
   Balakireva, Anastasia/AAQ-4082-2020
OI Shakhova, Ekaterina/0000-0002-6345-1330
FU Russian Federation [LS-2605.2020.4]; Russian Foundation for Basic
   Research [18-29-08049]
FX This work was funded by the President of the Russian Federation grant
   for leading scientific schools number LS-2605.2020.4 and by the Russian
   Foundation for Basic Research grant number 18-29-08049.
CR Ali NAA, 2003, FITOTERAPIA, V74, P483, DOI 10.1016/S0367-326X(03)00119-9
   Amaravadi R, 2005, J CLIN INVEST, V115, P2618, DOI 10.1172/JCI26273
   Anouar E, 2014, MOLECULES, V19, P3489, DOI 10.3390/molecules19033489
   Arlt A, 2003, ONCOGENE, V22, P3243, DOI 10.1038/sj.onc.1206390
   Beckert C, 1997, PHYTOCHEMISTRY, V44, P275, DOI 10.1016/S0031-9422(96)00543-2
   Bennett L, 2013, INT J MED MUSHROOMS, V15, P233, DOI 10.1615/IntJMedMushr.v15.i3.20
   Nguyen BCQ, 2016, PHYTOTHER RES, V30, P120, DOI 10.1002/ptr.5510
   Björnholm M, 2005, BIOCHEM SOC T, V33, P354
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Carvalho FS, 2014, MED RES REV, V34, P106, DOI 10.1002/med.21280
   Chandimali N, 2018, ANTICANCER RES, V38, P3967, DOI 10.21873/anticanres.12683
   Chen H, 2016, FITOTERAPIA, V113, P6, DOI 10.1016/j.fitote.2016.06.009
   Chen W, 2012, CHEM-BIOL INTERACT, V199, P137, DOI 10.1016/j.cbi.2012.07.001
   Chen WH, 2019, MOLECULES, V24, DOI 10.3390/molecules24101888
   Cho SY, 2003, B KOR CHEM SOC, V24, P1455
   Citron M, 2002, NAT NEUROSCI, V5, P1055, DOI 10.1038/nn940
   Curigliano G, 2016, CA-CANCER J CLIN, V66, P310, DOI 10.3322/caac.21341
   de Luca C, 2008, FEBS LETT, V582, P97, DOI 10.1016/j.febslet.2007.11.057
   Dugger BN, 2017, CSH PERSPECT BIOL, V9, DOI 10.1101/cshperspect.a028035
   EDWARDS RL, 1961, J CHEM SOC, P5003, DOI 10.1039/jr9610005003
   EDWARDS RL, 1961, J CHEM SOC, P4995, DOI 10.1039/jr9610004995
   Endemann DH, 2004, J AM SOC NEPHROL, V15, P1983, DOI 10.1097/01.ASN.0000132474.50966.DA
   Giardino I, 1996, J CLIN INVEST, V97, P1422, DOI 10.1172/JCI118563
   Golpich M, 2017, CNS NEUROSCI THER, V23, P5, DOI 10.1111/cns.12655
   Gonindard C, 1997, CELL BIOL TOXICOL, V13, P141, DOI 10.1023/A:1007321227010
   Grosso S, 2008, BIOCHEM J, V415, P77, DOI 10.1042/BJ20080463
   He PY, 2021, FOOD FUNCT, V12, P1856, DOI [10.1039/d0fo02342f, 10.1039/D0FO02342F]
   Hernández-Méndez A, 2014, EUR J PHARMACOL, V723, P124, DOI 10.1016/j.ejphar.2013.11.043
   Hobbs Christopher., 2002, Medicinal mushrooms: an Exploration of Tradition, Healing, and Culture
   Holm C, 2000, ANNU REV NUTR, V20, P365, DOI 10.1146/annurev.nutr.20.1.365
   Huang SY, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9080380
   Hwang BS, 2015, BIOORG MED CHEM LETT, V25, P3256, DOI 10.1016/j.bmcl.2015.05.081
   Incalza MA, 2018, VASC PHARMACOL, V100, P1, DOI 10.1016/j.vph.2017.05.005
   Isakov N, 2018, SEMIN CANCER BIOL, V48, P36, DOI 10.1016/j.semcancer.2017.04.012
   Ischiropoulos H, 2003, J CLIN INVEST, V111, P163, DOI 10.1172/JCI200317638
   Jang JS, 2010, ARCH PHARM RES, V33, P853, DOI 10.1007/s12272-010-0607-5
   Johnson TO, 2002, NAT REV DRUG DISCOV, V1, P696, DOI 10.1038/nrd895
   Joseph TP, 2018, INTEGR CANCER THER, V17, P200, DOI 10.1177/1534735417736861
   Jung JY, 2008, J APPL MICROBIOL, V104, P1824, DOI 10.1111/j.1365-2672.2008.03737.x
   Khandhadia S, 2010, EXPERT REV MOL MED, V12, DOI 10.1017/S146239941000164X
   Kim DE, 2014, EXP CELL RES, V327, P264, DOI 10.1016/j.yexcr.2014.07.037
   Kotlobay AA, 2018, P NATL ACAD SCI USA, V115, P12728, DOI 10.1073/pnas.1803615115
   Kozlowski D, 2007, RADIAT RES, V168, P243, DOI 10.1667/RR0824.1
   Lebiedzinska M, 2010, BBA-BIOENERGETICS, V1797, P952, DOI 10.1016/j.bbabio.2010.03.005
   Lee IK, 2011, J ANTIBIOT, V64, P349, DOI 10.1038/ja.2011.2
   Lee JH, 2011, J MED FOOD, V14, P1431, DOI 10.1089/jmf.2010.1493
   Lee YS, 2008, BIOL PHARM BULL, V31, P1968, DOI 10.1248/bpb.31.1968
   Lee YS, 2008, BIOL PHARM BULL, V31, P765, DOI 10.1248/bpb.31.765
   Lee YS, 2010, NAT PROD COMMUN, V5, P1927
   Lehrer S, 2020, IN VIVO, V34, P3023, DOI 10.21873/invivo.12134
   Li DY, 2003, CIRCULATION, V107, P612, DOI 10.1161/01.CIR.0000047276.52039.FB
   Li IC, 2020, FOOD SCI NUTR, V8, P1864, DOI 10.1002/fsn3.1469
   Li YB, 2015, BIOCHEM BIOPH RES CO, V468, P380, DOI 10.1016/j.bbrc.2015.10.079
   Lim JH, 2014, ANTICANCER RES, V34, P4087
   Lin MT, 2006, NATURE, V443, P787, DOI 10.1038/nature05292
   Liu Gang, 2002, Curr Opin Investig Drugs, V3, P1608
   Liu TT, 2020, BIOMED PHARMACOTHER, V128, DOI 10.1016/j.biopha.2020.110314
   Lv LX, 2017, ONCOTARGET, V8, P26992, DOI 10.18632/oncotarget.15935
   Maddu N., 2019, ANTIOXIDANTS
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   Moreira AC, 2014, BBA-MOL BASIS DIS, V1842, P2468, DOI 10.1016/j.bbadis.2014.09.015
   Naruse K, 2006, DIABETES, V55, P691, DOI 10.2337/diabetes.55.03.06.db05-0771
   Park IH, 2004, ARCH PHARM RES, V27, P615, DOI 10.1007/BF02980159
   Park IH, 2004, PLANTA MED, V70, P143, DOI 10.1055/s-2004-815491
   Park JM, 2015, MOLECULES, V20, P5456, DOI 10.3390/molecules20045456
   Pellicano F, 2009, BLOOD, V114, P4186, DOI 10.1182/blood-2009-05-219550
   Tu PTB, 2015, DRUG DISCOV THER, V9, P197, DOI 10.5582/ddt.2015.01038
   Tu PTB, 2014, MOLECULES, V19, P16656, DOI 10.3390/molecules191016656
   Piao SF, 2016, ANN NY ACAD SCI, V1371, P45, DOI 10.1111/nyas.12953
   Pinton P, 2008, CELL CYCLE, V7, P304, DOI 10.4161/cc.7.3.5360
   Pluskal T, 2019, NAT PLANTS, V5, P867, DOI 10.1038/s41477-019-0474-0
   Priyadarsini KI, 2003, FREE RADICAL BIO MED, V35, P475, DOI 10.1016/S0891-5849(03)00325-3
   Reddy VP, 2006, DRUG DISCOV TODAY, V11, P646, DOI 10.1016/j.drudis.2006.05.016
   Remedi MS, 2016, DIABETES OBES METAB, V18, P110, DOI 10.1111/dom.12727
   Rolo AP, 2006, TOXICOL APPL PHARM, V212, P167, DOI 10.1016/j.taap.2006.01.003
   Roy PS, 2016, INDIAN J CANCER, V53, P441, DOI 10.4103/0019-509X.200658
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sampaio SF, 2016, ARCH TOXICOL, V90, P1669, DOI 10.1007/s00204-015-1583-9
   Serseg T, 2021, CURR COMPUT-AID DRUG, V17, P469, DOI 10.2174/1573409916666200422075440
   Sherer T B, 2001, Curr Opin Investig Drugs, V2, P657
   Shin EJ, 2012, BEHAV BRAIN RES, V232, P98, DOI 10.1016/j.bbr.2012.04.001
   Smolskaite L, 2017, INT J MED MUSHROOMS, V19, P967, DOI 10.1615/IntJMedMushrooms.2017024522
   Song TY, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/4824371
   Stern D, 2002, ADV DRUG DELIVER REV, V54, P1615, DOI 10.1016/S0169-409X(02)00160-6
   Szabó C, 2003, TOXICOL LETT, V140, P105, DOI 10.1016/S0378-4274(02)00507-6
   Takano H, 2003, ANTIOXID REDOX SIGN, V5, P789, DOI 10.1089/152308603770380098
   Tamrakar S, 2019, J MED FOOD, V22, P225, DOI 10.1089/jmf.2018.4267
   Taylor SD, 2004, EXPERT OPIN INV DRUG, V13, P199, DOI 10.1517/eoid.13.3.199.27347
   Tian LW, 2017, BIOORG MED CHEM LETT, V27, P4007, DOI 10.1016/j.bmcl.2017.07.062
   Wang YW, 2004, INT J OBESITY, V28, P941, DOI 10.1038/sj.ijo.0802641
   Wangun HVK, 2006, ORG BIOMOL CHEM, V4, P2545, DOI 10.1039/b604505g
   WATLING R, 1992, MYCOL RES, V96, P743, DOI 10.1016/S0953-7562(09)80443-7
   Wei YZ, 2008, AM J PHYSIOL-REG I, V294, pR673, DOI 10.1152/ajpregu.00561.2007
   Weston CR, 2003, ONCOGENE, V22, P1281, DOI 10.1038/sj.onc.1206261
   Wojtala A, 2017, MITOCHONDRION, V37, P62, DOI 10.1016/j.mito.2017.07.002
   World Health Organization, 2018, KEY FACTS CANC
   Xie C, 2016, SCI REP-UK, V6, DOI 10.1038/srep27528
   Yamaguchi H, 2001, ONCOGENE, V20, P7779, DOI 10.1038/sj.onc.1204984
   Yamamori T, 2011, FREE RADICAL RES, V45, P342, DOI 10.3109/10715762.2010.532496
   Yazici D, 2017, ADV EXP MED BIOL, V960, P277, DOI 10.1007/978-3-319-48382-5_12
   Yeom Ji-Hee, 2012, Mycobiology, V40, P142, DOI 10.5941/MYCO.2012.40.2.142
   Yousfi M, 2009, PHYTOTHER RES, V23, P1237, DOI 10.1002/ptr.2543
   Yuan SY, 2000, CIRC RES, V87, P412
   Zan LF, 2011, CHEM PHARM BULL, V59, P770, DOI 10.1248/cpb.59.770
   Zhang HN, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-52711-7
   Zhao HQ, 2017, J CELL MOL MED, V21, P2055, DOI 10.1111/jcmm.13126
NR 106
TC 18
Z9 18
U1 0
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2309-608X
J9 J FUNGI
JI J. Fungi
PD MAY
PY 2021
VL 7
IS 5
AR 323
DI 10.3390/jof7050323
PG 13
WC Microbiology; Mycology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology; Mycology
GA SH7LF
UT WOS:000654314500001
PM 33922000
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ng, L
   Kaur, P
   Bunnag, N
   Suresh, J
   Sung, ICH
   Tan, QH
   Gruber, J
   Tolwinski, NS
AF Ng, Li Fang
   Kaur, Prameet
   Bunnag, Nawat
   Suresh, Jahnavi
   Sung, Isabelle Chiao Han
   Tan, Qian Hui
   Gruber, Jan
   Tolwinski, Nicholas S.
TI WNT Signaling in Disease
SO CELLS
LA English
DT Review
DE WNT; cancer; metabolic syndrome; Alzheimer's disease
ID WNT/BETA-CATENIN PATHWAY; RECEPTOR-RELATED PROTEIN-5; SMALL-MOLECULE
   INHIBITOR; FAMILIAL ADENOMATOUS POLYPOSIS; GLYCOGEN-SYNTHASE KINASE-3;
   FRAGILE-X-SYNDROME; CANCER STEM-CELLS; BETA-CATENIN; MATRIX
   METALLOPROTEINASE-7; OXIDATIVE STRESS
AB Developmental signaling pathways control a vast array of biological processes during embryogenesis and in adult life. The WNT pathway was discovered simultaneously in cancer and development. Recent advances have expanded the role of WNT to a wide range of pathologies in humans. Here, we discuss the WNT pathway and its role in human disease and some of the advances in WNT-related treatments.
C1 [Ng, Li Fang; Kaur, Prameet; Bunnag, Nawat; Suresh, Jahnavi; Sung, Isabelle Chiao Han; Tan, Qian Hui; Gruber, Jan; Tolwinski, Nicholas S.] Yale NUS Coll, Res Labs E6, Div Sci, E6,5 Engn Dr 1,04-02, Singapore 117608, Singapore.
C3 Yale NUS College
RP Tolwinski, NS (corresponding author), Yale NUS Coll, Res Labs E6, Div Sci, E6,5 Engn Dr 1,04-02, Singapore 117608, Singapore.
EM Nicholas.tolwinski@yale-nus.edu.sg
RI Tolwinski, Nicholas/Q-5782-2019
OI Tolwinski, Nicholas/0000-0002-8507-2737; Bunnag,
   Nawat/0000-0002-2594-0459; Sung, Isabelle Chiao Han/0000-0002-1449-4836;
   Tan, Qian Hui/0000-0002-5271-5476
FU Ministry of Education of Singapore through Yale-NUS [IG17-LR006,
   IG18-LR001]
FX We are thankful for the funding provided by Ministry of Education of
   Singapore through Yale-NUS grants IG17-LR006 and IG18-LR001.
CR Abitbol S, 2018, J HEPATOL, V68, P1203, DOI 10.1016/j.jhep.2017.12.018
   Adaimy L, 2007, AM J HUM GENET, V81, P821, DOI 10.1086/520064
   Aisagbonhi O, 2011, DIS MODEL MECH, V4, P469, DOI 10.1242/dmm.006510
   Akcora BÖ, 2018, BBA-MOL BASIS DIS, V1864, P804, DOI 10.1016/j.bbadis.2017.12.001
   Albuquerque C, 2010, GENE CHROMOSOME CANC, V49, P746, DOI 10.1002/gcc.20786
   Rosales-Reynoso MA, 2010, ARCH MED RES, V41, P110, DOI 10.1016/j.arcmed.2010.03.001
   Allen K, 2011, AM J PATHOL, V178, P175, DOI 10.1016/j.ajpath.2010.11.026
   Alzheimer A, 1995, Clin Anat, V8, P429
   Anastas JN, 2013, NAT REV CANCER, V13, P11, DOI 10.1038/nrc3419
   Angus-Hill ML, 2011, P NATL ACAD SCI USA, V108, P4914, DOI 10.1073/pnas.1102300108
   Arqués O, 2016, CLIN CANCER RES, V22, P644, DOI 10.1158/1078-0432.CCR-14-3081
   Asem MS, 2016, CANCERS, V8, DOI 10.3390/cancers8090079
   Barandon L, 2003, CIRCULATION, V108, P2282, DOI 10.1161/01.CIR.0000093186.22847.4C
   Barroga C, 2017, OSTEOARTHR CARTILAGE, V25, pS400, DOI 10.1016/j.joca.2017.02.688
   Belinson H, 2016, MOL PSYCHIATR, V21, P1417, DOI 10.1038/mp.2015.207
   Bertram L, 2008, AM J HUM GENET, V83, P623, DOI 10.1016/j.ajhg.2008.10.008
   Bhatt PM, 2014, ATHEROSCLEROSIS, V237, P155, DOI 10.1016/j.atherosclerosis.2014.08.027
   Bhattacharjee N, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00251
   Bilic J, 2007, SCIENCE, V316, P1619, DOI 10.1126/science.1137065
   Bornholdt D, 2009, HUM MUTAT, V30, pE618, DOI 10.1002/humu.20992
   Boyden LM, 2002, NEW ENGL J MED, V346, P1513, DOI 10.1056/NEJMoa013444
   Brabletz T, 1999, AM J PATHOL, V155, P1033, DOI 10.1016/S0002-9440(10)65204-2
   Brault V, 2001, DEVELOPMENT, V128, P1253
   Busceti CL, 2007, EPILEPSIA, V48, P694, DOI 10.1111/j.1528-1167.2007.01055.x
   Cadigan KM, 2012, CSH PERSPECT BIOL, V4, DOI 10.1101/cshperspect.a007906
   Cadigan KM, 1997, GENE DEV, V11, P3286, DOI 10.1101/gad.11.24.3286
   Campisi J, 2005, CELL, V120, P513, DOI 10.1016/j.cell.2005.02.003
   Caricasole A, 2004, J NEUROSCI, V24, P6021, DOI 10.1523/JNEUROSCI.1381-04.2004
   Catenacci DVT, 2015, J CLIN ONCOL, V33, P4284, DOI 10.1200/JCO.2015.62.8719
   Cervo PRD, 2017, NAT BIOTECHNOL, V35, P444, DOI 10.1038/nbt.3835
   Chapman A, 2011, J CLIN ENDOCR METAB, V96, pE1477, DOI 10.1210/jc.2010-2987
   Chen JY, 2006, J BIOL CHEM, V281, P11910, DOI 10.1074/jbc.M511920200
   Chen Y, 2007, PLOS MED, V4, P1216, DOI 10.1371/journal.pmed.0040249
   Chen Y, 2011, J BIOL CHEM, V286, P42575, DOI 10.1074/jbc.M111.294595
   Cheng PW, 2015, DIABETES, V64, P3413, DOI 10.2337/db14-1439
   Christie M, 2013, ONCOGENE, V32, P4675, DOI 10.1038/onc.2012.486
   Christman MA, 2008, AM J PHYSIOL-HEART C, V294, pH2864, DOI 10.1152/ajpheart.00982.2007
   Cohen P, 2001, NAT REV MOL CELL BIO, V2, P769, DOI 10.1038/35096075
   Collu GM, 2014, CELL MOL LIFE SCI, V71, P3553, DOI 10.1007/s00018-014-1644-x
   Colosimo PF, 2006, PLOS ONE, V1, DOI 10.1371/journal.pone.0000009
   Colosimo PF, 2010, DEV DYNAM, V239, P115, DOI 10.1002/dvdy.21963
   Craig VJ, 2015, AM J RESP CELL MOL, V53, P585, DOI 10.1165/rcmb.2015-0020TR
   Cummings S. R., 2007, Journal of Musculoskeletal & Neuronal Interactions, V7, P340
   Dai CS, 2009, J AM SOC NEPHROL, V20, P1997, DOI 10.1681/ASN.2009010019
   Dai JB, 2019, GENET TEST MOL BIOMA, V23, P393, DOI 10.1089/gtmb.2018.0309
   Damelin M, 2017, SCI TRANSL MED, V9, DOI 10.1126/scitranslmed.aag2611
   Davis S. L., 2019, Investig. New Drugs, V1, P10, DOI [10.1007/s10637-019, DOI 10.1007/S10637-019]
   De Calisto J, 2005, DEVELOPMENT, V132, P2587, DOI 10.1242/dev.01857
   De Ferrari GV, 2007, P NATL ACAD SCI USA, V104, P9434, DOI 10.1073/pnas.0603523104
   De Ferrari GV, 2014, CNS NEUROL DISORD-DR, V13, P745
   De Ferrari GV, 2003, MOL PSYCHIATR, V8, P195, DOI 10.1038/sj.mp.4001208
   DeCarolis NA, 2008, BIOESSAYS, V30, P102, DOI 10.1002/bies.20709
   Deshmukh V, 2019, OSTEOARTHR CARTILAGE, V27, P1347, DOI 10.1016/j.joca.2019.05.006
   Deshmukh V, 2018, ANN RHEUM DIS, V77, P249, DOI 10.1136/annrheumdis-2018-eular.4752
   Deshmukh V, 2018, OSTEOARTHR CARTILAGE, V26, P18, DOI 10.1016/j.joca.2017.08.015
   Dey N, 2013, BMC CANCER, V13, DOI 10.1186/1471-2407-13-537
   Ding M, 2017, ONCOL LETT, V14, P6327, DOI 10.3892/ol.2017.7030
   Dissanayake SK, 2007, J BIOL CHEM, V282, P17259, DOI 10.1074/jbc.M700075200
   Dunn NR, 2016, CANCERS, V8, DOI 10.3390/cancers8070068
   Ehyai S, 2018, EMBO REP, V19, DOI 10.15252/embr.201745536
   Eisenmann David M, 2005, WormBook, P1, DOI 10.1895/wormbook.1.7.1
   Ellies DL, 2006, J BONE MINER RES, V21, P1738, DOI 10.1359/JBMR.060810
   Enomoto M, 2009, ONCOGENE, V28, P3197, DOI 10.1038/onc.2009.175
   Essers MAG, 2005, SCIENCE, V308, P1181, DOI 10.1126/science.1109083
   Fahiminiya S, 2013, J MED GENET, V50, P345, DOI 10.1136/jmedgenet-2013-101567
   Fischer MM, 2017, SCI ADV, V3, DOI 10.1126/sciadv.1700090
   Fodde R, 2002, EUR J CANCER, V38, P867, DOI 10.1016/S0959-8049(02)00040-0
   Folestad A, 2015, ACTA ORTHOP, V86, P415, DOI 10.3109/17453674.2015.1033606
   Folke J, 2019, MOL NEUROBIOL, V56, P873, DOI 10.1007/s12035-018-1103-z
   Fortress AM, 2013, J NEUROSCI, V33, P12619, DOI 10.1523/JNEUROSCI.0659-13.2013
   Foulkes WD, 1995, QJM-MON J ASSOC PHYS, V88, P853
   Foulquier S, 2018, PHARMACOL REV, V70, P68, DOI 10.1124/pr.117.013896
   Friedl W, 2005, HERED CANCER CLIN PR, V3, P95, DOI 10.1186/1897-4287-3-3-95
   Frost HM, 1998, CALCIFIED TISSUE INT, V62, P1, DOI 10.1007/s002239900384
   Fujino T, 2003, P NATL ACAD SCI USA, V100, P229, DOI 10.1073/pnas.0133792100
   Ge WS, 2014, MOL MED REP, V9, P2145, DOI 10.3892/mmr.2014.2099
   Giannakis M, 2014, NAT GENET, V46, P1264, DOI 10.1038/ng.3127
   Giefing M, 2016, EUR J CANCER, V55, P147, DOI 10.1016/j.ejca.2015.10.070
   Go GW, 2014, CELL METAB, V19, P209, DOI 10.1016/j.cmet.2013.11.023
   Gong YQ, 2001, CELL, V107, P513, DOI 10.1016/S0092-8674(01)00571-2
   Gonias SL, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0186649
   Graeff C, 2015, BONE, V81, P364, DOI 10.1016/j.bone.2015.07.036
   Grant SFA, 2006, NAT GENET, V38, P320, DOI 10.1038/ng1732
   Gruber J, 2016, CANCERS, V8, DOI 10.3390/cancers8080073
   Gudjonsson JE, 2010, J INVEST DERMATOL, V130, P1849, DOI 10.1038/jid.2010.67
   Guo QY, 2019, PHARMACOL RES, V144, P151, DOI 10.1016/j.phrs.2019.03.022
   Guo Y, 2007, J ORTHOP RES, V25, P964, DOI 10.1002/jor.20356
   Gurney A, 2012, P NATL ACAD SCI USA, V109, P11717, DOI 10.1073/pnas.1120068109
   Habas R, 2001, CELL, V107, P843, DOI 10.1016/S0092-8674(01)00614-6
   Habas Raymond, 2005, J Biol, V4, P2, DOI 10.1186/jbiol22
   HANGER DP, 1992, NEUROSCI LETT, V147, P58, DOI 10.1016/0304-3940(92)90774-2
   Hao S, 2011, J AM SOC NEPHROL, V22, P1642, DOI 10.1681/ASN.2010101079
   HARMAN D, 1981, P NATL ACAD SCI-BIOL, V78, P7124, DOI 10.1073/pnas.78.11.7124
   He WC, 2012, J AM SOC NEPHROL, V23, P294, DOI 10.1681/ASN.2011050490
   He WC, 2009, J AM SOC NEPHROL, V20, P765, DOI 10.1681/ASN.2008060566
   He X, 2004, DEVELOPMENT, V131, P1663, DOI 10.1242/dev.01117
   Henderson WR, 2010, P NATL ACAD SCI USA, V107, P14309, DOI 10.1073/pnas.1001520107
   Heneka MT, 2015, LANCET NEUROL, V14, P388, DOI 10.1016/S1474-4422(15)70016-5
   Herman PE, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-017-18757-1
   Ho C, 2012, AM J MED SCI, V344, P374, DOI 10.1097/MAJ.0b013e31824369c5
   Hodges SL, 2018, EPILEPSY RES, V146, P9, DOI 10.1016/j.eplepsyres.2018.07.002
   Hoeppner LH, 2009, EXPERT OPIN THER TAR, V13, P485, DOI [10.1517/14728220902841961 , 10.1517/14728220902841961]
   Hollingworth P, 2011, NAT GENET, V43, P429, DOI 10.1038/ng.803
   Hong QX, 2016, INT J CLIN EXP MED, V9, P6376
   Hooper C, 2008, J NEUROCHEM, V104, P1433, DOI 10.1111/j.1471-4159.2007.05194.x
   Horne L, 2016, TRANSL ONCOL, V9, P438, DOI 10.1016/j.tranon.2016.08.010
   Hoseth EZ, 2018, TRANSL PSYCHIAT, V8, DOI 10.1038/s41398-018-0102-1
   Hrckulak D, 2016, CANCERS, V8, DOI 10.3390/cancers8070070
   Iftikhar H, 2014, PHARMACOGN MAG, V10, P264, DOI 10.4103/0973-1296.133269
   Inestrosa NC, 2014, J MOL CELL BIOL, V6, P64, DOI 10.1093/jmcb/mjt051
   Ito M, 2007, NATURE, V447, P316, DOI 10.1038/nature05766
   James BD, 2014, NEUROLOGY, V82, P1045, DOI 10.1212/WNL.0000000000000240
   Janda CY, 2012, SCIENCE, V337, P59, DOI 10.1126/science.1222879
   Jiang XM, 2013, P NATL ACAD SCI USA, V110, P12649, DOI 10.1073/pnas.1307218110
   Jin T, 2008, DIABETOLOGIA, V51, P1771, DOI 10.1007/s00125-008-1084-y
   Johnson ML, 2017, CURR OSTEOPOROS REP, V15, P153, DOI 10.1007/s11914-017-0357-0
   Jolivalt CG, 2012, NEUROSCIENCE, V202, P405, DOI 10.1016/j.neuroscience.2011.11.032
   Kaidi A, 2007, NAT CELL BIOL, V9, P210, DOI 10.1038/ncb1534
   Kanazawa A, 2004, AM J HUM GENET, V75, P832, DOI 10.1086/425340
   Kanzawa M, 2013, PATHOBIOLOGY, V80, P235, DOI 10.1159/000346843
   Kaplan NA, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0018616
   Kaplan NA, 2010, J CELL SCI, V123, P3157, DOI 10.1242/jcs.069898
   Kaplan NA, 2009, GENETICS, V183, P897, DOI 10.1534/genetics.109.108878
   Katsu T, 2003, NEUROSCI LETT, V353, P53, DOI 10.1016/j.neulet.2003.09.017
   Kaur P, 2018, GENES-BASEL, V9, DOI 10.3390/genes9020101
   Kawakami T, 2013, J PATHOL, V229, P221, DOI 10.1002/path.4121
   Kennedy ME, 2016, SCI TRANSL MED, V8, DOI 10.1126/scitranslmed.aad9704
   Kestler HA, 2008, PHILOS T R SOC B, V363, P1333, DOI 10.1098/rstb.2007.2251
   Khanra R, 2017, BIOMED PHARMACOTHER, V94, P726, DOI 10.1016/j.biopha.2017.07.112
   Khanra R, 2015, J TRANSL MED, V13, DOI 10.1186/s12967-014-0364-1
   Khramtsov AI, 2010, AM J PATHOL, V176, P2911, DOI 10.2353/ajpath.2010.091125
   Killick R, 2014, MOL PSYCHIATR, V19, P88, DOI 10.1038/mp.2012.163
   King MR, 2015, NEUROSCIENCE, V303, P220, DOI 10.1016/j.neuroscience.2015.06.060
   King TD, 2012, J CELL BIOCHEM, V113, P13, DOI 10.1002/jcb.23350
   KINZLER KW, 1991, SCIENCE, V253, P661, DOI 10.1126/science.1651562
   Ko AH, 2016, J CLIN ONCOL, V34, DOI 10.1200/JCO.2016.34.15_suppl.e15721
   Kohn AD, 2005, CELL CALCIUM, V38, P439, DOI 10.1016/j.ceca.2005.06.022
   Kokubu C, 2004, DEVELOPMENT, V131, P5469, DOI 10.1242/dev.01405
   Komatsu DE, 2010, J ORTHOP RES, V28, P928, DOI 10.1002/jor.21078
   Komiya Yuko, 2008, Organogenesis, V4, P68
   Koval A, 2012, DRUG DISCOV TODAY, V17, P1316, DOI 10.1016/j.drudis.2012.07.007
   Krausova M, 2014, CELL SIGNAL, V26, P570, DOI 10.1016/j.cellsig.2013.11.032
   Krishnamurthy N, 2018, CANCER TREAT REV, V62, P50, DOI 10.1016/j.ctrv.2017.11.002
   Kumawat K, 2013, FASEB J, V27, P1631, DOI 10.1096/fj.12-217539
   Kuncewitch M, 2015, SHOCK, V43, P268, DOI 10.1097/SHK.0000000000000293
   Kurosu H, 2005, SCIENCE, V309, P1829, DOI 10.1126/science.1112766
   Kuwahara K, 2011, J PHARMACOL SCI, V116, P337, DOI 10.1254/jphs.10R28FM
   L'Episcopo F, 2011, NEUROBIOL DIS, V41, P508, DOI 10.1016/j.nbd.2010.10.023
   L'Episcopo F, 2014, STEM CELLS, V32, P2147, DOI 10.1002/stem.1708
   Laine CM, 2013, NEW ENGL J MED, V368, P1809, DOI 10.1056/NEJMoa1215458
   Lambert JC, 2013, NAT GENET, V45, P1452, DOI 10.1038/ng.2802
   Lammi L, 2004, AM J HUM GENET, V74, P1043, DOI 10.1086/386293
   Lee YJ, 2010, AM J PHYSIOL-RENAL, V298, pF1263, DOI 10.1152/ajprenal.00475.2009
   Leedham SJ, 2013, GUT, V62, P83, DOI 10.1136/gutjnl-2011-301601
   Lehwald N, 2011, GASTROENTEROLOGY, V141, P707, DOI 10.1053/j.gastro.2011.04.051
   Lemberger UJ, 2016, ONCOTARGET, V7, P86985, DOI 10.18632/oncotarget.13521
   Lenz HJ, 2014, CANCER SCI, V105, P1087, DOI 10.1111/cas.12471
   Lepourcelet M, 2004, CANCER CELL, V5, P91, DOI 10.1016/S1535-6108(03)00334-9
   LEVY E, 1990, SCIENCE, V248, P1124, DOI 10.1126/science.2111584
   Li XF, 2005, J BIOL CHEM, V280, P19883, DOI 10.1074/jbc.M413274200
   Li ZH, 2014, CHINESE MED J-PEKING, V127, P3464, DOI 10.3760/cma.j.issn.0366-6999.20141347
   Lim HW, 2002, BIOCHEM BIOPH RES CO, V299, P806, DOI 10.1016/S0006-291X(02)02741-9
   Lin CC, 2018, CANCER LETT, V438, P165, DOI 10.1016/j.canlet.2018.09.022
   Lin CL, 2008, AM J NEPHROL, V28, P290, DOI 10.1159/000111142
   Lin SL, 2010, P NATL ACAD SCI USA, V107, P4194, DOI 10.1073/pnas.0912228107
   Linnemannstöns K, 2014, PLOS GENET, V10, DOI 10.1371/journal.pgen.1004443
   Little RD, 2002, AM J HUM GENET, V70, P11, DOI 10.1086/338450
   Liu CM, 2002, CELL, V108, P837, DOI 10.1016/S0092-8674(02)00685-2
   Liu HJ, 2007, SCIENCE, V317, P803, DOI 10.1126/science.1143578
   Liu HJ, 2011, SCI SIGNAL, V4, DOI 10.1126/scisignal.2001249
   Liu YH, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0084407
   Liu ZY, 2008, J BIOL CHEM, V283, P8723, DOI 10.1074/jbc.M706105200
   Logan CY, 2004, ANNU REV CELL DEV BI, V20, P781, DOI 10.1146/annurev.cellbio.20.010403.113126
   Lolli F, 2017, ENDOCRINE, V57, P9, DOI 10.1007/s12020-017-1280-y
   Loregger A, 2015, SCI SIGNAL, V8, DOI 10.1126/scisignal.aac6757
   Lu B, 2016, CANCERS, V8, DOI 10.3390/cancers8090082
   Lu WY, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0029290
   Lu XW, 2004, NATURE, V430, P93, DOI 10.1038/nature02677
   Lucero OM, 2010, CURR ONCOL REP, V12, P314, DOI 10.1007/s11912-010-0114-3
   Maarouf OH, 2016, J AM SOC NEPHROL, V27, P781, DOI 10.1681/ASN.2014121188
   MacDonald BT, 2009, DEV CELL, V17, P9, DOI 10.1016/j.devcel.2009.06.016
   Madan B, 2016, ONCOGENE, V35, P2197, DOI 10.1038/onc.2015.280
   Madan B, 2018, J CLIN INVEST, V128, P5620, DOI 10.1172/JCI122383
   Malgor R, 2014, INFLAMM RES, V63, P277, DOI 10.1007/s00011-013-0697-x
   Mani A, 2007, SCIENCE, V315, P1278, DOI 10.1126/science.1136370
   Maruotti N, 2017, J CELL PHYSIOL, V232, P2957, DOI 10.1002/jcp.25969
   Matsui T, 2005, GENE DEV, V19, P164, DOI 10.1101/gad.1253605
   Mazzardo-Martins L, 2012, NEUROSCIENCE, V226, P411, DOI 10.1016/j.neuroscience.2012.09.020
   McGrath JJ, 2003, ANN MED, V35, P86, DOI 10.1080/07853890310010005
   Michalopoulos GK, 1997, SCIENCE, V276, P60, DOI 10.1126/science.276.5309.60
   Minde DP, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0077257
   Minde DP, 2011, MOL CANCER, V10, DOI 10.1186/1476-4598-10-101
   Mirotsou M, 2007, P NATL ACAD SCI USA, V104, P1643, DOI 10.1073/pnas.0610024104
   Miyamoto K, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0184388
   Miyaoka T, 1999, SCHIZOPHR RES, V38, P1, DOI 10.1016/S0920-9964(98)00179-0
   Miyoshi Yasuo, 1992, Human Molecular Genetics, V1, P229
   Monga SPS, 2001, HEPATOLOGY, V33, P1098, DOI 10.1053/jhep.2001.23786
   Moore KN, 2019, GYNECOL ONCOL, V154, P294, DOI 10.1016/j.ygyno.2019.04.001
   Morfini G, 2002, EMBO J, V21, P281, DOI 10.1093/emboj/21.3.281
   Morishita Y, 2016, SCI REP-UK, V6, DOI 10.1038/srep21705
   MOSSIE K, 1995, ONCOGENE, V11, P2179
   Mostowska A, 2006, J HUM GENET, V51, P262, DOI 10.1007/s10038-005-0353-6
   Motono M, 2016, STEM CELL TRANSL MED, V5, P552, DOI 10.5966/sctm.2015-0261
   Mulligan KA, 2012, J NEUROIMMUNE PHARM, V7, P774, DOI 10.1007/s11481-012-9404-x
   Nakamura K, 2016, J BIOL CHEM, V291, P2566, DOI 10.1074/jbc.M115.693937
   Nelsen CJ, 2001, CANCER RES, V61, P8564
   Nishikawa T, 2007, ANTIOXID REDOX SIGN, V9, P343, DOI 10.1089/ars.2006.1458
   Nusse R, 2005, CELL RES, V15, P28, DOI 10.1038/sj.cr.7290260
   NUSSE R, 1991, CELL, V64, P231, DOI 10.1016/0092-8674(91)90633-A
   NUSSE R, 1982, CELL, V31, P99, DOI 10.1016/0092-8674(82)90409-3
   Nusse R, 2008, CELL RES, V18, P523, DOI 10.1038/cr.2008.47
   NUSSLEINVOLHARD C, 1980, NATURE, V287, P795, DOI 10.1038/287795a0
   NUSSLEINVOLHARD C, 1984, ROUX ARCH DEV BIOL, V193, P267, DOI 10.1007/BF00848156
   Oliva CA, 2018, PROG MOL BIOL TRANSL, V153, P81, DOI 10.1016/bs.pmbts.2017.11.018
   Olson EN, 2003, GENE DEV, V17, P1937, DOI 10.1101/gad.1110103
   Owen KR, 2007, CURR OPIN GENET DEV, V17, P239, DOI 10.1016/j.gde.2007.04.003
   Paik DT, 2015, CIRC RES, V117, P804, DOI 10.1161/CIRCRESAHA.115.306886
   Pardo A, 2016, RESP RES, V17, DOI 10.1186/s12931-016-0343-6
   Pataki CA, 2015, J HISTOCHEM CYTOCHEM, V63, P465, DOI 10.1369/0022155415586961
   Peng JP, 2012, KIDNEY INT, V82, P509, DOI 10.1038/ki.2012.155
   Peradziryi H, 2012, ARCH BIOCHEM BIOPHYS, V524, P71, DOI 10.1016/j.abb.2011.12.019
   Peradziryi H, 2011, EMBO J, V30, P3729, DOI 10.1038/emboj.2011.236
   Pfister AS, 2018, PROG MOL BIOL TRANSL, V153, P131, DOI 10.1016/bs.pmbts.2017.11.006
   Planas-Paz L, 2016, NAT CELL BIOL, V18, P467, DOI 10.1038/ncb3337
   Polakis P, 1999, CURR OPIN GENET DEV, V9, P15, DOI 10.1016/S0959-437X(99)80003-3
   Polakis P, 2000, GENE DEV, V14, P1837
   Pongracz JE, 2006, RESP RES, V7, DOI 10.1186/1465-9921-7-15
   POWELL SM, 1992, NATURE, V359, P235, DOI 10.1038/359235a0
   Prahallad A, 2016, ONCOGENE, V35, P1073, DOI 10.1038/onc.2015.151
   Proffitt KD, 2013, CANCER RES, V73, P502, DOI 10.1158/0008-5472.CAN-12-2258
   Qian LH, 2011, P NATL ACAD SCI USA, V108, P8692, DOI 10.1073/pnas.1100328108
   Queimado L, 2007, GENE CHROMOSOME CANC, V46, P215, DOI 10.1002/gcc.20402
   Rao TP, 2010, CIRC RES, V106, P1798, DOI 10.1161/CIRCRESAHA.110.219840
   Recker RR, 2015, J BONE MINER RES, V30, P216, DOI 10.1002/jbmr.2351
   Regitz-Zagrosek V, 2016, EUR HEART J, V37, P24, DOI 10.1093/eurheartj/ehv598
   Ren DN, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms7906
   Reuter S, 2014, J IMMUNOL, V193, P485, DOI 10.4049/jimmunol.1400013
   Reya T, 2005, NATURE, V434, P843, DOI 10.1038/nature03319
   Roslan Z, 2019, J ONCOL, V2019, DOI 10.1155/2019/4536302
   Rulifson IC, 2007, P NATL ACAD SCI USA, V104, P6247, DOI 10.1073/pnas.0701509104
   Santoro MR, 2012, ANNU REV PATHOL-MECH, V7, P219, DOI 10.1146/annurev-pathol-011811-132457
   Sarzani R, 2011, NUTR METAB CARDIOVAS, V21, P150, DOI 10.1016/j.numecd.2009.08.004
   Satoh S, 2000, NAT GENET, V24, P245, DOI 10.1038/73448
   Scali C, 2006, NEUROBIOL DIS, V24, P254, DOI 10.1016/j.nbd.2006.06.016
   Schlessinger K, 2009, GENE DEV, V23, P265, DOI 10.1101/gad.1760809
   Sen M, 2000, P NATL ACAD SCI USA, V97, P2791, DOI 10.1073/pnas.050574297
   Sen M, 2001, ARTHRITIS RHEUM, V44, P772, DOI 10.1002/1529-0131(200104)44:4<772::AID-ANR133>3.0.CO;2-L
   Serrano FG, 2014, MOL NEURODEGENER, V9, DOI 10.1186/1750-1326-9-61
   Serrano-Pozo A, 2011, CSH PERSPECT MED, V1, DOI 10.1101/cshperspect.a006189
   Sethi JK, 2010, BIOCHEM J, V427, P1, DOI 10.1042/BJ20091866
   Seykora J, 2017, J AM ACAD DERMATOL, V76, pAB223
   SHARMA RP, 1976, DEV BIOL, V48, P461, DOI 10.1016/0012-1606(76)90108-1
   Shu L, 2008, DIABETES, V57, P645, DOI 10.2337/db07-0847
   Slusarski DC, 2007, DEV BIOL, V307, P1, DOI 10.1016/j.ydbio.2007.04.043
   Song B, 2010, J BIOL CHEM, V285, P41122, DOI 10.1074/jbc.M110.130351
   Speese SD, 2007, TRENDS NEUROSCI, V30, P268, DOI 10.1016/j.tins.2007.04.003
   Sumithra B, 2016, CELL ONCOL, V39, P1, DOI 10.1007/s13402-015-0266-0
   Surendran K, 2005, J AM SOC NEPHROL, V16, P2373, DOI 10.1681/ASN.2004110949
   Suresh J, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-11519-z
   Tabatadze N, 2012, HIPPOCAMPUS, V22, P1228, DOI 10.1002/hipo.20991
   Tacchelly-Benites O, 2018, PLOS GENET, V14, DOI 10.1371/journal.pgen.1007178
   Takamatsu A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0092699
   Takashima A, 1998, P NATL ACAD SCI USA, V95, P9637, DOI 10.1073/pnas.95.16.9637
   Tamamura Y, 2005, J BIOL CHEM, V280, P19185, DOI 10.1074/jbc.M414275200
   Tan RJ, 2014, KIDNEY INT SUPPL, V4, P84, DOI 10.1038/kisup.2014.16
   Tan XP, 2006, GASTROENTEROLOGY, V131, P1561, DOI 10.1053/j.gastro.2006.08.042
   Tapia-Rojas C, 2016, J NEUROCHEM, V139, P1175, DOI 10.1111/jnc.13873
   Teneggi V, 2016, ANN ONCOL, V27
   Teng Y, 2010, BIOCHEM BIOPH RES CO, V392, P373, DOI 10.1016/j.bbrc.2010.01.028
   Terada Y, 2003, J AM SOC NEPHROL, V14, P1223, DOI 10.1097/01.ASN.0000060577.94532.06
   Thorgeirsson SS, 1996, FASEB J, V10, P1249, DOI 10.1096/fasebj.10.11.8836038
   Thorvaldsen TE, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0170508
   Tian Y, 2010, PEDIATR CARDIOL, V31, P342, DOI 10.1007/s00246-009-9606-z
   Todd PK, 2002, J NEUROSCI RES, V70, P623, DOI 10.1002/jnr.10453
   Toledo EM, 2010, MOL PSYCHIATR, V15, P272, DOI 10.1038/mp.2009.72
   Tolwinski NS, 2004, NAT CELL BIOL, V6, P579, DOI 10.1038/ncb0704-579
   Tsedensodnom O, 2011, EXP CELL RES, V317, P920, DOI 10.1016/j.yexcr.2011.01.015
   Tsukiyama T, 2015, MOL CELL BIOL, V35, P2007, DOI 10.1128/MCB.00159-15
   Tung EKK, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036565
   Twells RCJ, 2003, HUM GENET, V113, P99, DOI 10.1007/s00439-003-0940-6
   Twells RCJ, 2003, GENOME RES, V13, P845, DOI 10.1101/gr.563703
   Tzouvelekis A, 2017, RESPIROLOGY, V22, P486, DOI 10.1111/resp.12920
   Ueland T, 2009, ARTERIOSCL THROM VAS, V29, P1228, DOI 10.1161/ATVBAHA.109.189761
   van Amerongen R, 2009, DEVELOPMENT, V136, P3205, DOI 10.1242/dev.033910
   van de Wetering M, 2002, CELL, V111, P241, DOI 10.1016/S0092-8674(02)01014-0
   van Gijn ME, 2002, CARDIOVASC RES, V55, P16, DOI 10.1016/S0008-6363(02)00221-3
   Veeman MT, 2003, DEV CELL, V5, P367, DOI 10.1016/S1534-5807(03)00266-1
   Wang XL, 2013, J MED CHEM, V56, P2700, DOI 10.1021/jm400159c
   Wang ZY, 2009, J AM SOC NEPHROL, V20, P1919, DOI 10.1681/ASN.2009030253
   Webster MR, 2015, PIGM CELL MELANOMA R, V28, P184, DOI 10.1111/pcmr.12330
   Weedon MN, 2007, DIABETIC MED, V24, P1062, DOI 10.1111/j.1464-5491.2007.02258.x
   Weuve Jennifer, 2014, Alzheimers Dement, V10, pe40, DOI 10.1016/j.jalz.2014.01.004
   White BD, 2007, CURR BIOL, V17, pR923, DOI 10.1016/j.cub.2007.08.062
   Winberg ML, 2001, NEURON, V32, P53, DOI 10.1016/S0896-6273(01)00446-9
   Wodarz A, 1998, ANNU REV CELL DEV BI, V14, P59, DOI 10.1146/annurev.cellbio.14.1.59
   Wu ZQ, 2012, P NATL ACAD SCI USA, V109, P11312, DOI 10.1073/pnas.1203015109
   Xiao L., 2013, Biomed Res Int, P987064, DOI [10.1155/2013/987064, DOI 10.1155/2013/987064]
   Xiao LX, 2016, J AM SOC NEPHROL, V27, P1727, DOI 10.1681/ASN.2015040449
   Yang E, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms11430
   Yang J, 2014, HEPATOLOGY, V60, P964, DOI 10.1002/hep.27082
   Yazici Y, 2017, OSTEOARTHR CARTILAGE, V25, P1598, DOI 10.1016/j.joca.2017.07.006
   Ye XF, 2007, MOL CELL, V27, P183, DOI 10.1016/j.molcel.2007.05.034
   Yeh TH, 2010, HEPATOLOGY, V52, P1410, DOI 10.1002/hep.23801
   Zeng L, 1997, CELL, V90, P181, DOI 10.1016/S0092-8674(00)80324-4
   Zhan T, 2017, ONCOGENE, V36, P1461, DOI 10.1038/onc.2016.304
   Zhang AY, 2009, BIOCHEM BIOPH RES CO, V379, P920, DOI 10.1016/j.bbrc.2008.12.172
   Zhang L, 2016, SCI TRANSL MED, V8, DOI 10.1126/scitranslmed.aaf8127
   Zhang LS, 2016, J GENET GENOMICS, V43, P587, DOI 10.1016/j.jgg.2016.05.002
   Zhang RG, 2005, DEV CELL, V8, P19, DOI 10.1016/j.devcel.2004.10.019
   Zhang YH, 2012, NEUROCHEM RES, V37, P1409, DOI 10.1007/s11064-012-0724-2
   Zhang ZH, 2017, ONCOTARGET, V8, P69316, DOI 10.18632/oncotarget.20613
   Zhao Y, 2016, ONCOGENE, V35, P3705, DOI 10.1038/onc.2015.438
   Zheng HH, 2017, J NEUROSCI, V37, P1772, DOI 10.1523/JNEUROSCI.2459-16.2017
   Zhong Y, 2016, TOXICOL PATHOL, V44, P267, DOI 10.1177/0192623315621192
   Zhou D, 2017, J AM SOC NEPHROL, V28, P2322, DOI 10.1681/ASN.2016080902
   Zhou D, 2017, J AM SOC NEPHROL, V28, P598, DOI 10.1681/ASN.2016030354
   Zhou D, 2016, LAB INVEST, V96, P156, DOI 10.1038/labinvest.2015.153
   Zhou LL, 2015, J AM SOC NEPHROL, V26, P107, DOI 10.1681/ASN.2014010085
   Zimmerman ZF, 2012, CSH PERSPECT BIOL, V4, DOI 10.1101/cshperspect.a008086
   Zou XR, 2016, EXP THER MED, V12, P3515, DOI 10.3892/etm.2016.3800
   Zou Y, 2013, GENE, V531, P112, DOI 10.1016/j.gene.2013.08.054
NR 321
TC 177
Z9 195
U1 2
U2 48
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD AUG
PY 2019
VL 8
IS 8
AR 826
DI 10.3390/cells8080826
PG 32
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA IV8TI
UT WOS:000484537500059
PM 31382613
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Hannou, SA
   Haslam, DE
   McKeown, NM
   Herman, MA
AF Hannou, Sarah A.
   Haslam, Danielle E.
   McKeown, Nicola M.
   Herman, Mark A.
TI Fructose metabolism and metabolic disease
SO JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Review
ID SWEETENED BEVERAGE CONSUMPTION; ELEMENT-BINDING PROTEIN; HEPATIC
   INSULIN-RESISTANCE; CORONARY-HEART-DISEASE; DE-NOVO LIPOGENESIS;
   GROWTH-FACTOR 21; URIC-ACID; DIETARY FRUCTOSE; OXIDATIVE STRESS; ALDOSE
   REDUCTASE
AB Increased sugar consumption is increasingly considered to be a contributor to the worldwide epidemics of obesity and diabetes and their associated cardiometabolic risks. As a result of its unique metabolic properties, the fructose component of sugar may be particularly harmful. Diets high in fructose can rapidly produce all of the key features of the metabolic syndrome. Here we review the biology of fructose metabolism as well as potential mechanisms by which excessive fructose consumption may contribute to cardiometabolic disease.
C1 [Hannou, Sarah A.; Herman, Mark A.] Duke Univ, Med Ctr, Div Endocrinol & Metab, Durham, NC 27705 USA.
   [Hannou, Sarah A.; Herman, Mark A.] Duke Univ, Med Ctr, Duke Mol Physiol Inst, Durham, NC 27705 USA.
   [Haslam, Danielle E.; McKeown, Nicola M.] Tufts Univ, Nutr Epidemiol Program, Jean Mayer US Dept Agr, Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
C3 Duke University; Duke University; Tufts University; United States
   Department of Agriculture (USDA)
RP Herman, MA (corresponding author), Duke Univ, 300 N Duke St,Carmichael Bldg, Durham, NC 27705 USA.
EM mark.herman@duke.edu
RI Herman, Mark/H-3232-2012; Haslam, Danielle/V-8846-2019; hannou,
   sarah/AAT-2902-2020
OI Hannou, Sarah A/0000-0003-4780-5773; Haslam,
   Danielle/0000-0003-0144-3287; Herman, Mark/0000-0001-6979-103X
FU American Heart Association [16CSA28590003]; NIH [R01DK100425,
   5T32HL069772-15]; US Department of Agriculture Agricultural Research
   Service [58-1950-4-003]
FX This work is supported by American Heart Association 16CSA28590003 (to
   MAH and NMM), NIH R01DK100425 (to MAH), NIH 5T32HL069772-15 (to DEH),
   and US Department of Agriculture Agricultural Research Service agreement
   58-1950-4-003 (to NMM).
CR Adams SH, 2008, ENDOCRINOLOGY, V149, P3002, DOI 10.1210/en.2007-1812
   Agius L, 2008, BIOCHEM J, V414, P1, DOI 10.1042/BJ20080595
   Ali M, 1998, J MED GENET, V35, P353, DOI 10.1136/jmg.35.5.353
   [Anonymous], DIET GUID AM 2015 20
   Asipu A, 2003, DIABETES, V52, P2426, DOI 10.2337/diabetes.52.9.2426
   Avena NM, 2007, EXP CLIN PSYCHOPHARM, V15, P481, DOI 10.1037/1064-1297.15.5.481
   Badman MK, 2007, CELL METAB, V5, P426, DOI 10.1016/j.cmet.2007.05.002
   Baraille F, 2015, PHYSIOLOGY, V30, P428, DOI 10.1152/physiol.00016.2015
   Barone S, 2009, J BIOL CHEM, V284, P5056, DOI 10.1074/jbc.M808128200
   Batis C, 2016, PLOS MED, V13, DOI 10.1371/journal.pmed.1002057
   BECKNIELSEN H, 1980, AM J CLIN NUTR, V33, P273, DOI 10.1093/ajcn/33.2.273
   BELFIORE F, 1989, BIOCHEM MED METAB B, V41, P77, DOI 10.1016/0885-4505(89)90011-X
   Benhamed F, 2012, J CLIN INVEST, V122, P2176, DOI 10.1172/JCI41636
   BISMUT H, 1993, EUR J BIOCHEM, V213, P721, DOI 10.1111/j.1432-1033.1993.tb17812.x
   BJORKMAN O, 1982, DIABETES, V31, P516, DOI 10.2337/diabetes.31.6.516
   BLAKELY SR, 1981, J NUTR, V111, P307, DOI 10.1093/jn/111.2.307
   Boergesen M, 2011, J BIOL CHEM, V286, P13214, DOI 10.1074/jbc.M110.215467
   BONTHRON DT, 1994, HUM MOL GENET, V3, P1627, DOI 10.1093/hmg/3.9.1627
   BOSCA L, 1984, TRENDS BIOCHEM SCI, V9, P372, DOI 10.1016/0968-0004(84)90214-7
   Brown KS, 1997, DIABETES, V46, P179, DOI 10.2337/diabetes.46.2.179
   BURCH HB, 1969, BIOCHEM BIOPH RES CO, V34, P619, DOI 10.1016/0006-291X(69)90783-9
   Campos VC, 2016, INT J OBESITY, V40, pS6, DOI 10.1038/ijo.2016.8
   Caron S, 2011, ARTERIOSCL THROM VAS, V31, P513, DOI 10.1161/ATVBAHA.110.220723
   Chambers KT, 2013, MOL METAB, V2, P194, DOI 10.1016/j.molmet.2013.05.001
   Chan SMH, 2013, DIABETES, V62, P2095, DOI 10.2337/db12-1397
   Chang CH, 2009, ARCH GERONTOL GERIAT, V49, pS46, DOI 10.1016/S0167-4943(09)70013-5
   Chavez AO, 2009, DIABETES CARE, V32, P1542, DOI 10.2337/dc09-0684
   CHENG HM, 1986, METABOLISM, V35, P10, DOI 10.1016/0026-0495(86)90180-0
   Choi YJ, 2014, FASEB J, V28, P3197, DOI 10.1096/fj.13-247148
   Chotiwat C., 2007, APPETITE, V49, P284
   Chu AY, 2013, HUM MOL GENET, V22, P1895, DOI 10.1093/hmg/ddt032
   Chung M, 2014, AM J CLIN NUTR, V100, P833, DOI 10.3945/ajcn.114.086314
   Crescenzo R, 2013, EUR J NUTR, V52, P537, DOI 10.1007/s00394-012-0356-y
   Cui XL, 2004, PHYSIOL GENOMICS, V18, P206, DOI 10.1152/physiolgenomics.00056.2004
   CURRY DL, 1989, PANCREAS, V4, P2, DOI 10.1097/00006676-198902000-00002
   Czech MP, 2017, NAT MED, V23, P804, DOI 10.1038/nm.4350
   DAS B, 1985, DIABETES, V34, P1145, DOI 10.2337/diabetes.34.11.1145
   DAVIS JD, 1973, PHYSIOL BEHAV, V11, P39, DOI 10.1016/0031-9384(73)90120-0
   de Koning L, 2012, CIRCULATION, V125, P1735, DOI 10.1161/CIRCULATIONAHA.111.067017
   DeBosch BJ, 2014, J BIOL CHEM, V289, P10989, DOI 10.1074/jbc.M113.527002
   Dentin R, 2012, J HEPATOL, V56, P199, DOI 10.1016/j.jhep.2011.07.019
   Dhingra R, 2007, CIRCULATION, V116, P480, DOI 10.1161/CIRCULATIONAHA.107.689935
   Diggle CP, 2009, J HISTOCHEM CYTOCHEM, V57, P763, DOI 10.1369/jhc.2009.953190
   Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI23621
   Dotimas JR, 2016, ELIFE, V5, DOI 10.7554/eLife.18313
   Dushay J, 2010, GASTROENTEROLOGY, V139, P456, DOI 10.1053/j.gastro.2010.04.054
   Dushay JR, 2015, MOL METAB, V4, P51, DOI 10.1016/j.molmet.2014.09.008
   EGGLESTON LV, 1970, FEBS LETT, V6, P43, DOI 10.1016/0014-5793(70)80038-2
   Erion DM, 2013, ENDOCRINOLOGY, V154, P36, DOI 10.1210/en.2012-1725
   Falbe J, 2016, AM J PUBLIC HEALTH, V106, P1865, DOI 10.2105/AJPH.2016.303362
   Farese RV, 2012, CELL METAB, V15, P570, DOI 10.1016/j.cmet.2012.03.004
   Ferraris RP, 2001, BIOCHEM J, V360, P265, DOI 10.1042/0264-6021:3600265
   Filhoulaud G, 2013, TRENDS ENDOCRIN MET, V24, P257, DOI 10.1016/j.tem.2013.01.003
   Fisher FM, 2017, MOL METAB, V6, P14, DOI 10.1016/j.molmet.2016.11.008
   Fisher FM, 2010, DIABETES, V59, P2781, DOI 10.2337/db10-0193
   Flamment M, 2012, TRENDS ENDOCRIN MET, V23, P381, DOI 10.1016/j.tem.2012.06.003
   Frenette G, 2006, J ANDROL, V27, P233, DOI 10.2164/jandrol.05108
   Fu ZY, 2014, SCI REP-UK, V4, DOI 10.1038/srep05013
   Fung TT, 2009, AM J CLIN NUTR, V89, P1037, DOI 10.3945/ajcn.2008.27140
   Gibson PR, 2007, ALIMENT PHARM THER, V25, P349, DOI 10.1111/j.1365-2036.2006.03186.x
   GINSBURG V, 1960, BIOCHIM BIOPHYS ACTA, V38, P427, DOI 10.1016/0006-3002(60)91278-6
   Green AK, 2014, OBESITY, V22, pE157, DOI 10.1002/oby.20724
   Haas JT, 2012, CELL METAB, V15, P873, DOI 10.1016/j.cmet.2012.05.002
   Hayward BE, 1998, EUR J BIOCHEM, V257, P85, DOI 10.1046/j.1432-1327.1998.2570085.x
   Heizer WD, 2009, J AM DIET ASSOC, V109, P1204, DOI 10.1016/j.jada.2009.04.012
   Hellerstein MK, 1996, ANNU REV NUTR, V16, P523, DOI 10.1146/annurev.nu.16.070196.002515
   Herman MA, 2016, TRENDS ENDOCRIN MET, V27, P719, DOI 10.1016/j.tem.2016.06.005
   Herman MA, 2012, NATURE, V484, P333, DOI 10.1038/nature10986
   HERS H. G., 1961, ENZYMOL BIOL ET CLIN, V1, P4
   HERS HG, 1982, BIOCHEM J, V206, P1
   Hert KA, 2014, NUTR RES, V34, P58, DOI 10.1016/j.nutres.2013.10.005
   Holdsworth CD, 1991, SUGARS IN NUTR
   Hudgins LC, 2011, J CLIN ENDOCR METAB, V96, P861, DOI 10.1210/jc.2010-2007
   HUUPPONEN R, 1989, DIABETES RES CLIN EX, V10, P143
   Hwang JJ, 2017, JCI INSIGHT, V2, DOI 10.1172/jci.insight.90508
   Hwang JI, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0141728
   Iizuka K, 2004, P NATL ACAD SCI USA, V101, P7281, DOI 10.1073/pnas.0401516101
   Iizuka K, 2009, FEBS LETT, V583, P2882, DOI 10.1016/j.febslet.2009.07.053
   Imamura F, 2015, BMJ-BRIT MED J, V351, DOI 10.1136/bmj.h3576
   Inagaki T, 2007, CELL METAB, V5, P415, DOI 10.1016/j.cmet.2007.05.003
   Ishimoto T, 2012, P NATL ACAD SCI USA, V109, P4320, DOI 10.1073/pnas.1119908109
   Jamnik J, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2016-013191
   Jayalath VH, 2015, AM J CLIN NUTR, V102, P914, DOI 10.3945/ajcn.115.107243
   Jayaraman V, 2014, J ASSIST REPROD GEN, V31, P1195, DOI 10.1007/s10815-014-0282-4
   JEDZINIAK JA, 1981, INVEST OPHTH VIS SCI, V20, P314
   Johnson RK, 2009, CIRCULATION, V120, P1011, DOI 10.1161/CIRCULATIONAHA.109.192627
   Johnson RJ, 2003, HYPERTENSION, V41, P1183, DOI 10.1161/01.HYP.0000069700.62727.C5
   Kammoun HL, 2009, J CLIN INVEST, V119, P1201, DOI 10.1172/JCI37007
   Karim S, 2012, WORLD J GASTROENTERO, V18, P6771, DOI 10.3748/wjg.v18.i46.6771
   Kathiresan S, 2008, NAT GENET, V40, P189, DOI 10.1038/ng.75
   Kelishadi R, 2014, NUTRITION, V30, P503, DOI 10.1016/j.nut.2013.08.014
   Khan TA, 2016, EUR J NUTR, V55, pS25, DOI 10.1007/s00394-016-1345-3
   Kim MS, 2016, J CLIN INVEST, V126, P4372, DOI 10.1172/JCI81993
   Kim M, 2017, JCI INSIGHT, V2, DOI 10.1172/jci.insight.96703
   Kit BK, 2013, AM J CLIN NUTR, V98, P180, DOI 10.3945/ajcn.112.057943
   Koo HY, 2009, BIOCHEM BIOPH RES CO, V390, P285, DOI 10.1016/j.bbrc.2009.09.109
   Kooner JS, 2008, NAT GENET, V40, P149, DOI 10.1038/ng.2007.61
   Kumashiro N, 2011, P NATL ACAD SCI USA, V108, P16381, DOI 10.1073/pnas.1113359108
   Kuzma JN, 2016, AM J CLIN NUTR, V104, P306, DOI 10.3945/ajcn.115.129650
   La Vignera S, 2012, J ANDROL, V33, P145, DOI 10.2164/jandrol.111.013193
   Laeger T., J Clin Invest
   Lam P., BERKELEY SCI J
   Lanaspa MA, 2014, J AM SOC NEPHROL, V25, P2526, DOI 10.1681/ASN.2013080901
   Lanaspa MA, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3434
   Lanaspa MA, 2012, J BIOL CHEM, V287, P40732, DOI 10.1074/jbc.M112.399899
   Lanaspa MA, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0047948, 10.1371/journal.pone.0048801]
   Lanaspa MA, 2011, SEMIN NEPHROL, V31, P426, DOI 10.1016/j.semnephrol.2011.08.006
   Lee AH, 2008, SCIENCE, V320, P1492, DOI 10.1126/science.1158042
   Li SJ, 2010, P NATL ACAD SCI USA, V107, P3441, DOI 10.1073/pnas.0914798107
   Li XJ, 2016, NAT CELL BIOL, V18, P561, DOI 10.1038/ncb3338
   Li X, 2017, BMJ-BRIT MED J, V357, DOI 10.1136/bmj.j2376
   Lim JS, 2010, NAT REV GASTRO HEPAT, V7, P251, DOI 10.1038/nrgastro.2010.41
   Lin JD, 2005, CELL METAB, V1, P361, DOI 10.1016/j.cmet.2005.05.004
   Lin JD, 2005, CELL, V120, P261, DOI 10.1016/j.cell.2004.11.043
   Lin JD, 2002, J BIOL CHEM, V277, P1645, DOI 10.1074/jbc.C100631200
   Liu M, 2014, INT J ENDOCRINOL, V2014, DOI 10.1155/2014/754678
   Lonsdale J, 2013, NAT GENET, V45, P580, DOI 10.1038/ng.2653
   Lorenzi M, 2007, EXP DIABETES RES, DOI 10.1155/2007/61038
   Luo S, 2015, P NATL ACAD SCI USA, V112, P6509, DOI 10.1073/pnas.1503358112
   Ma JT, 2016, CIRCULATION, V133, P370, DOI 10.1161/CIRCULATIONAHA.115.018704
   Maersk M, 2012, AM J CLIN NUTR, V95, P283, DOI 10.3945/ajcn.111.022533
   Malhi H., J Hepatol
   Malik VS, 2013, AM J CLIN NUTR, V98, P1084, DOI 10.3945/ajcn.113.058362
   Manolescu AR, 2007, PHYSIOLOGY, V22, P234, DOI 10.1152/physiol.00011.2007
   Marriott BP., J Nutr
   Martini AC, 2010, FERTIL STERIL, V94, P1739, DOI 10.1016/j.fertnstert.2009.11.017
   Mathebula SD, 2015, AFR VISION EYE HLTH, V74
   MAVRIAS DA, 1973, BIOCHIM BIOPHYS ACTA, V291, P531, DOI 10.1016/0005-2736(73)90504-X
   McGarry JD, 2002, DIABETES, V51, P7, DOI 10.2337/diabetes.51.1.7
   McGuinness OP, 2003, CURR OPIN CLIN NUTR, V6, P441, DOI 10.1097/01.mco.0000078990.96795.cd
   Mirtschink P, 2015, NATURE, V522, P444, DOI 10.1038/nature14508
   Nagai Y., Cell Metab
   Niculescu L, 1997, BIOCHEM J, V321, P239, DOI 10.1042/bj3210239
   NIEWOEHNER CB, 1984, AM J PHYSIOL, V247, pE505, DOI 10.1152/ajpendo.1984.247.4.E505
   Oates PJ, 2002, INT REV NEUROBIOL, V50, P325
   Oppelt SA, 2015, MOL GENET METAB, V114, P445, DOI 10.1016/j.ymgme.2015.01.001
   Page KA, 2013, JAMA-J AM MED ASSOC, V309, P63, DOI 10.1001/jama.2012.116975
   Parks EJ, 2008, J NUTR, V138, P1039, DOI 10.1093/jn/138.6.1039
   Patel C, 2015, AM J PHYSIOL-REG I, V309, pR499, DOI 10.1152/ajpregu.00128.2015
   Patel C, 2015, FASEB J, V29, P4046, DOI 10.1096/fj.15-272195
   Peterson TR, 2011, CELL, V146, P408, DOI 10.1016/j.cell.2011.06.034
   Preston GM, 2010, BIOMARK INSIGHTS, V5, P33
   Puig JG, 2008, CURR OPIN RHEUMATOL, V20, P187, DOI 10.1097/BOR.0b013e3282f4b1ed
   RAIVIO KO, 1975, METABOLISM, V24, P861, DOI 10.1016/0026-0495(75)90133-X
   RAND EB, 1993, AM J PHYSIOL, V264, pG1169, DOI 10.1152/ajpgi.1993.264.6.G1169
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   REAVEN GM, 1991, AM HEART J, V121, P1283, DOI 10.1016/0002-8703(91)90434-J
   Rosinger Asher, 2017, NCHS Data Brief, P1
   RUMESSEN JJ, 1992, SCAND J GASTROENTERO, V27, P819, DOI 10.3109/00365529209000148
   RUMESSEN JJ, 1986, GUT, V27, P1161, DOI 10.1136/gut.27.10.1161
   SAHEBJAMI H, 1971, LANCET, V1, P366
   Samuel VT, 2004, J BIOL CHEM, V279, P32345, DOI 10.1074/jbc.M313478200
   Sánchez J, 2009, ENDOCRINOLOGY, V150, P5341, DOI 10.1210/en.2009-0466
   Sautin YY, 2007, AM J PHYSIOL-CELL PH, V293, pC584, DOI 10.1152/ajpcell.00600.2006
   SESTOFT L, 1974, BIOCHIM BIOPHYS ACTA, V345, P27, DOI 10.1016/0005-2736(74)90242-9
   Shapiro A, 2008, AM J PHYSIOL-REG I, V295, pR1370, DOI 10.1152/ajpregu.00195.2008
   Singh AK, 2008, KIDNEY INT, V74, P438, DOI 10.1038/ki.2008.184
   Skoog SM, 2004, AM J GASTROENTEROL, V99, P2046, DOI 10.1111/j.1572-0241.2004.40266.x
   Sobrecases H, 2010, DIABETES METAB, V36, P244, DOI 10.1016/j.diabet.2010.03.003
   Softic S, 2017, J CLIN INVEST, V127, P4059, DOI 10.1172/JCI94585
   Spangler R, 2004, MOL BRAIN RES, V124, P134, DOI 10.1016/j.molbrainres.2004.02.013
   Stanhope KL, 2016, CRIT REV CL LAB SCI, V53, P52, DOI 10.3109/10408363.2015.1084990
   Stanhope KL, 2015, AM J CLIN NUTR, V101, P1144, DOI 10.3945/ajcn.114.100461
   Stanhope KL, 2013, CURR OPIN LIPIDOL, V24, P198, DOI 10.1097/MOL.0b013e3283613bca
   Stanhope KL, 2009, J CLIN INVEST, V119, P1322, DOI 10.1172/JCI37385
   STEINITZ H, 1969, NEW ENGL J MED, V280, P222
   Sugimoto K, FOOD SCI TECHNOL RES
   Sugimoto K, 2010, J CLIN BIOCHEM NUTR, V46, P205, DOI 10.3164/jcbn.09-93
   Talukdar S, 2016, CELL METAB, V23, P344, DOI 10.1016/j.cmet.2015.12.008
   Tanaka T, 2013, AM J CLIN NUTR, V97, P1395, DOI 10.3945/ajcn.112.052183
   Tapia E, 2013, AM J PHYSIOL-RENAL, V304, pF727, DOI 10.1152/ajprenal.00485.2012
   Tappy L, 2012, CLIN RES HEPATOL GAS, V36, P554, DOI 10.1016/j.clinre.2012.06.005
   Taskinen MR, 2017, J INTERN MED, V282, P187, DOI 10.1111/joim.12632
   Teff KL, 2004, J CLIN ENDOCR METAB, V89, P2963, DOI 10.1210/jc.2003-031855
   Tellez LA, 2016, NAT NEUROSCI, V19, P465, DOI 10.1038/nn.4224
   Templeman NM, 2017, CELL REP, V20, P451, DOI 10.1016/j.celrep.2017.06.048
   ter Horst KW, 2017, NUTRIENTS, V9, DOI 10.3390/nu9090981
   ter Horst KW, 2016, AM J CLIN NUTR, V104, P1562, DOI 10.3945/ajcn.116.137786
   THURSTON JH, 1974, DIABETES, V23, P597, DOI 10.2337/diab.23.7.597
   TOPPING DL, 1972, BIOCHEM J, V126, P295, DOI 10.1042/bj1260295
   TOPPING DL, 1976, BRIT J NUTR, V36, P113, DOI 10.1079/BJN19760062
   Uyeda K, 2006, CELL METAB, V4, P107, DOI 10.1016/j.cmet.2006.06.008
   VANDENBERGHE G, 1977, BIOCHEM J, V162, P601, DOI 10.1042/bj1620601
   VANDENBERGHE G, 1973, BIOCHEM J, V134, P637
   VANSCHAFTINGEN E, 1989, EUR J BIOCHEM, V179, P179
   von Holstein-Rathlou S, 2016, CELL METAB, V23, P335, DOI 10.1016/j.cmet.2015.12.003
   Vos MB, 2017, CIRCULATION, V135, pE1017, DOI 10.1161/CIR.0000000000000439
   Wahjudi PN, 2010, CLIN BIOCHEM, V43, P198, DOI 10.1016/j.clinbiochem.2009.08.028
   WHO, Guideline: Sugar intake for adults and children
   Wideman CH, 2005, NUTR NEUROSCI, V8, P269, DOI 10.1080/10284150500485221
   Wood IS, 2003, BRIT J NUTR, V89, P3, DOI 10.1079/BJN2002763
   ZAVARONI I, 1982, METABOLISM, V31, P1077, DOI 10.1016/0026-0495(82)90155-X
   Zhang DQ, 2017, J CLIN INVEST, V127, P2855, DOI 10.1172/JCI89934
NR 193
TC 378
Z9 415
U1 14
U2 173
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA
SN 0021-9738
EI 1558-8238
J9 J CLIN INVEST
JI J. Clin. Invest.
PD FEB 1
PY 2018
VL 128
IS 2
BP 545
EP 555
DI 10.1172/JCI96702
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FV5YY
UT WOS:000424659500001
PM 29388924
OA Green Published, Bronze, Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Sundaram, V
   Morgan, TR
AF Sundaram, Vinay
   Morgan, Timothy R.
TI Will Studies in Nonalcoholic Steatohepatitis Help Manage Alcoholic
   Steatohepatitis?
SO CLINICS IN LIVER DISEASE
LA English
DT Article
DE Alcoholic cirrhosis; Fatty liver disease; Alcoholic liver disease; Anti
   -fibrotic; Anti-inflammatory
ID ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE; LIVER; CELLS;
   PATHOGENESIS; INFLAMMATION; ACID; MICE; PROGRESSION; METABOLISM
AB Hepatic steatosis and steatohepatitis have several etiologies; the most common are alcoholic steatohepatitis (ASH) and obesity/metabolic syndrome-induced steatohepatitis, also known as nonalcoholic steatohepatitis (NASH). Although the etiology of these 2 conditions is different, they share pathways to disease progression and severity. They also have differences in physiologic pathways, and shared and divergent mechanisms can be therapeutic targets. There is no approved pharmacologic therapy for NASH, but several molecules are under study. Focus remains on modulation of insulin resistance, oxidative stress, the inflammatory cascade, hepatic fibrosis, and cell death. This review provides an overview of pathophysiologic similarities and differences between ASH and NASH.
C1 [Sundaram, Vinay] Cedars Sinai Med Ctr, Dept Med, Comprehens Transplant Ctr, 8900 Beverly Blvd,Suite 250, Los Angeles, CA 90048 USA.
   [Morgan, Timothy R.] VA Long Beach Healthcare Syst, Gastroenterol Sect, 5901 East Seventh St 11G, Long Beach, CA 90822 USA.
C3 Cedars Sinai Medical Center; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); VA Long Beach Healthcare System
RP Morgan, TR (corresponding author), VA Long Beach Healthcare Syst, Gastroenterol Sect, 5901 East Seventh St 11G, Long Beach, CA 90822 USA.
EM Timothy.morgan@va.gov
FU National Institute on Alcohol Abuse and Alcoholism [U01 AA 21886]
FX Supported in part by a grant from the National Institute on Alcohol
   Abuse and Alcoholism (U01 AA 21886) to Dr T.R. Morgan.
CR Alessi MC, 2003, ARTERIOSCL THROM VAS, V23, P1262, DOI 10.1161/01.ATV.0000077401.36885.BB
   Alkhouri N, 2012, LIVER INT, V32, P297, DOI 10.1111/j.1478-3231.2011.02639.x
   Barreyro FJ, 2015, LIVER INT, V35, P953, DOI 10.1111/liv.12570
   Beier JI, 2010, BIOL CHEM, V391, P1249, DOI 10.1515/BC.2010.137
   Brenner C, 2013, J HEPATOL, V59, P583, DOI 10.1016/j.jhep.2013.03.033
   Cani PD, 2007, DIABETOLOGIA, V50, P2374, DOI 10.1007/s00125-007-0791-0
   Di Prospero NA, 2014, DIABETES OBES METAB, V16, P1055, DOI 10.1111/dom.12309
   Dimova E, 2008, THROMB HAEMOSTASIS, V100, P992, DOI 10.1160/TH08-07-0490
   Dominguez M, 2009, GASTROENTEROLOGY, V136, P1639, DOI 10.1053/j.gastro.2009.01.056
   Dunn W, 2016, CLIN LIVER DIS, V20, P445, DOI 10.1016/j.cld.2016.02.004
   Foster DW, 2012, J CLIN INVEST, V122, P1958, DOI 10.1172/JCI63967
   Friedman SL, 2018, HEPATOLOGY, V67, P1754, DOI 10.1002/hep.29477
   Gao B, 2011, AM J PHYSIOL-GASTR L, V300, pG516, DOI 10.1152/ajpgi.00537.2010
   Gustot T, 2006, HEPATOLOGY, V43, P989, DOI 10.1002/hep.21138
   Harrison SA, 2016, ALIMENT PHARM THER, V44, P1183, DOI 10.1111/apt.13816
   Henao-Mejia J, 2012, NATURE, V482, P179, DOI 10.1038/nature10809
   Henderson NC, 2009, IMMUNOL REV, V230, P160, DOI 10.1111/j.1600-065X.2009.00794.x
   Ibusuki R, 2013, LIVER INT, V33, P1549, DOI 10.1111/liv.12203
   Ji C, 2003, GASTROENTEROLOGY, V124, P1488, DOI 10.1016/S0016-5085(03)00276-2
   Ji C, 2014, INT J HEPATOL, V2014, DOI 10.1155/2014/513787
   Joka D, 2012, HEPATOLOGY, V55, P455, DOI 10.1002/hep.24734
   Joshi-Barve S, 2015, CELL MOL GASTROENTER, V1, P356, DOI 10.1016/j.jcmgh.2015.05.006
   Kammoun HL, 2009, J CLIN INVEST, V119, P1201, DOI 10.1172/JCI37007
   Konerman MA, 2018, J HEPATOL, V68, P362, DOI 10.1016/j.jhep.2017.10.015
   Lee BP, 2018, GASTROENTEROLOGY, V155, P422, DOI 10.1053/j.gastro.2018.04.009
   Leroux A, 2012, J HEPATOL, V57, P141, DOI 10.1016/j.jhep.2012.02.028
   Locatelli I, 2013, CLIN SCI, V124, P279, DOI 10.1042/CS20120289
   Loomba R, 2018, HEPATOLOGY, V67, P549, DOI 10.1002/hep.29514
   Louvet A, 2007, HEPATOLOGY, V45, P1348, DOI 10.1002/hep.21607
   Luedde T, 2014, GASTROENTEROLOGY, V147, P765, DOI 10.1053/j.gastro.2014.07.018
   Marra F, 2014, GASTROENTEROLOGY, V147, P577, DOI 10.1053/j.gastro.2014.06.043
   Mathurin P, 2011, NEW ENGL J MED, V365, P1790, DOI 10.1056/NEJMoa1105703
   Mederacke I, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3823
   Miura K, 2012, AM J PHYSIOL-GASTR L, V302, pG1310, DOI 10.1152/ajpgi.00365.2011
   Miura K, 2010, GASTROENTEROLOGY, V139, P323, DOI 10.1053/j.gastro.2010.03.052
   Mizrahi M, 2012, J INFLAMM RES, V5, P141, DOI 10.2147/JIR.S35227
   Moon HJ, 2014, BIOORG CHEM, V57, P231, DOI 10.1016/j.bioorg.2014.07.003
   Ota T, 2008, J CLIN INVEST, V118, P316, DOI 10.1172/JCI32752
   Owumi SE, 2014, ENVIRON TOXICOL, V29, P867, DOI 10.1002/tox.21814
   Purohit V, 2008, ALCOHOL, V42, P349, DOI 10.1016/j.alcohol.2008.03.131
   Ramirez T, 2013, J GASTROEN HEPATOL, V28, P179, DOI 10.1111/j.1440-1746.2012.07256.x
   Rivera CA, 2007, J HEPATOL, V47, P571, DOI 10.1016/j.jhep.2007.04.019
   Ronis MJ, 2010, ALCOHOL, V44, P157, DOI 10.1016/j.alcohol.2009.11.002
   RUBIN E, 1968, NEW ENGL J MED, V278, P869, DOI 10.1056/NEJM196804182781602
   Singal AK, 2018, AM J GASTROENTEROL, V113, P175, DOI 10.1038/ajg.2017.469
   Sofair AN, 2010, J CLIN GASTROENTEROL, V44, P301, DOI 10.1097/MCG.0b013e3181b3f760
   Sumida Y, 2018, J GASTROENTEROL, V53, P362, DOI 10.1007/s00535-017-1415-1
   Sun LP, 2007, P NATL ACAD SCI USA, V104, P6519, DOI 10.1073/pnas.0700907104
   Sutti S, 2014, HEPATOLOGY, V59, P886, DOI 10.1002/hep.26749
   Swann JR, 2011, P NATL ACAD SCI USA, V108, P4523, DOI 10.1073/pnas.1006734107
   Syn WK, 2012, GUT, V61, P1323, DOI 10.1136/gutjnl-2011-301857
   Tajiri K, 2009, EUR J GASTROEN HEPAT, V21, P673, DOI 10.1097/MEG.0b013e32831bc3d6
   Thiele GM, 2010, ALCOHOL CLIN EXP RES, V34, P2126, DOI 10.1111/j.1530-0277.2010.01309.x
   Thursz MR, 2015, NEW ENGL J MED, V373, P282
   Verbeke L, 2014, HEPATOLOGY, V59, P2286, DOI 10.1002/hep.26939
   Wang ZN, 2011, NATURE, V472, P57, DOI 10.1038/nature09922
   Weston CJ, 2015, J CLIN INVEST, V125, P501, DOI 10.1172/JCI73722
   Winau F, 2007, IMMUNITY, V26, P117, DOI 10.1016/j.immuni.2006.11.011
   Zhang XQ, 2014, WORLD J GASTROENTERO, V20, P1768, DOI 10.3748/wjg.v20.i7.1768
NR 59
TC 6
Z9 6
U1 0
U2 6
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1089-3261
EI 1557-8224
J9 CLIN LIVER DIS
JI Clin. Liver Dis.
PD FEB
PY 2019
VL 23
IS 1
BP 157
EP +
DI 10.1016/j.cld.2018.09.008
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA HF6TY
UT WOS:000454372400014
PM 30454829
DA 2025-06-11
ER

PT J
AU Yu, EPK
   Bennett, MR
AF Yu, Emma P. K.
   Bennett, Martin R.
TI The role of mitochondrial DNA damage in the development of
   atherosclerosis
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Review
DE Mitochondria; Atherosclerosis; Inflammation
ID PERMEABILITY TRANSITION PORE; SMOOTH-MUSCLE-CELLS; NLRP3 INFLAMMASOME;
   OXIDATIVE STRESS; ACCELERATES ATHEROSCLEROSIS; PROMOTES ATHEROSCLEROSIS;
   ENERGY HOMEOSTASIS; METABOLIC SYNDROME; MTDNA MUTATIONS; ATP SYNTHASE
AB Mitochondria are the cellular powerhouses, fuelling metabolic processes through their generation of ATP. However we now recognise that these organelles also have pivotal roles in producing reactive oxygen species (ROS) and in regulating cell death, inflammation and metabolism. Mitochondrial dysfunction therefore leads to oxidative stress, cell death, metabolic dysfunction and inflammation, which can all promote atherosclerosis. Recent evidence indicates that mitochondrial DNA (mtDNA) damage is present and promotes atherosclerosis through mitochondrial dysfunction. We will review the mechanisms that link mtDNA damage with atherosclerotic disease, and identify mitochondrial processes that may have therapeutic benefit. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Yu, Emma P. K.; Bennett, Martin R.] Univ Cambridge, Addenbrookes Hosp, Addenbrookes Ctr Clin Invest, Div Cardiovasc Med, Box 110, Cambridge CB2 2QQ, England.
C3 University of Cambridge; Cambridge University Hospitals NHS Foundation
   Trust; Addenbrooke's Hospital
RP Yu, EPK (corresponding author), Univ Cambridge, Addenbrookes Hosp, Addenbrookes Ctr Clin Invest, Div Cardiovasc Med, Box 110, Cambridge CB2 2QQ, England.
EM epky2@cam.ac.uk
OI Bennett, Martin/0000-0002-2565-1825
FU British Heart Foundation [PG/14/69/31032, RG/13/14/30314]; National
   Institute for Health Research Cambridge Biomedical Research Centre;
   Academy of Medical Sciences
FX This work was supported by British Heart Foundation grants
   PG/14/69/31032 and RG/13/14/30314, the National Institute for Health
   Research Cambridge Biomedical Research Centre, and the Academy of
   Medical Sciences.
CR Ahn BH, 2008, P NATL ACAD SCI USA, V105, P14447, DOI 10.1073/pnas.0803790105
   Alavian KN, 2014, P NATL ACAD SCI USA, V111, P10580, DOI 10.1073/pnas.1401591111
   ANDERSON S, 1981, NATURE, V290, P457, DOI 10.1038/290457a0
   Ballinger SW, 2002, CIRCULATION, V106, P544, DOI 10.1161/01.CIR.0000023921.93743.89
   BERLINER JA, 1995, CIRCULATION, V91, P2488, DOI 10.1161/01.CIR.91.9.2488
   Botto N, 2005, MUTAT RES-FUND MOL M, V570, P81, DOI 10.1016/j.mrfmmm.2004.10.003
   Chen HC, 2010, CELL, V141, P280, DOI 10.1016/j.cell.2010.02.026
   Chen YH, 2011, EMBO REP, V12, P534, DOI 10.1038/embor.2011.65
   Chen Y, 2013, SCIENCE, V340, P471, DOI 10.1126/science.1231031
   Chu CT, 2013, NAT CELL BIOL, V15, P1197, DOI 10.1038/ncb2837
   Cimen H, 2010, BIOCHEMISTRY-US, V49, P304, DOI 10.1021/bi901627u
   Clarke MCH, 2008, CIRC RES, V102, P1529, DOI 10.1161/CIRCRESAHA.108.175976
   Clarke MCH, 2006, NAT MED, V12, P1075, DOI 10.1038/nm1459
   Cochemé HM, 2012, NAT PROTOC, V7, P946, DOI 10.1038/nprot.2012.035
   CORRALDEBRINSKI M, 1992, MUTAT RES, V275, P169, DOI 10.1016/0921-8734(92)90021-G
   Cuchel M, 2006, CIRCULATION, V113, P2548, DOI 10.1161/CIRCULATIONAHA.104.475715
   Dai DF, 2010, AGING CELL, V9, P536, DOI 10.1111/j.1474-9726.2010.00581.x
   Duewell P, 2010, NATURE, V464, P1357, DOI 10.1038/nature08938
   Freigang S, 2013, NAT IMMUNOL, V14, P1045, DOI 10.1038/ni.2704
   Frezza C, 2006, CELL, V126, P177, DOI 10.1016/j.cell.2006.06.025
   Friedman JR, 2014, NATURE, V505, P335, DOI 10.1038/nature12985
   Geisler S, 2010, NAT CELL BIOL, V12, P119, DOI 10.1038/ncb2012
   Giorgio V, 2013, P NATL ACAD SCI USA, V110, P5887, DOI 10.1073/pnas.1217823110
   Goossens P, 2010, CELL METAB, V12, P142, DOI 10.1016/j.cmet.2010.06.008
   Gorenne I, 2013, CIRCULATION, V127, P386, DOI 10.1161/CIRCULATIONAHA.112.124404
   Gray K, 2015, CIRC RES, V116, P816, DOI 10.1161/CIRCRESAHA.116.304921
   Halestrap AP, 2004, CARDIOVASC RES, V61, P372, DOI 10.1016/S0008-6363(03)00533-9
   Hardie DG, 2012, NAT REV MOL CELL BIO, V13, P251, DOI 10.1038/nrm3311
   HARMAN D, 1972, J AM GERIATR SOC, V20, P145, DOI 10.1111/j.1532-5415.1972.tb00787.x
   Hirschey MD, 2010, NATURE, V464, P121, DOI 10.1038/nature08778
   Hotta Y, 2009, ENDOCRINOLOGY, V150, P4625, DOI 10.1210/en.2009-0119
   Ishihara N, 2009, NAT CELL BIOL, V11, P958, DOI 10.1038/ncb1907
   Iyer SS, 2013, IMMUNITY, V39, P311, DOI 10.1016/j.immuni.2013.08.001
   Jiang X, 2014, P NATL ACAD SCI USA, V111, P14782, DOI 10.1073/pnas.1417253111
   Karunakaran D, 2015, CIRC RES, V117, P266, DOI 10.1161/CIRCRESAHA.117.305624
   Kazak L, 2012, NAT REV MOL CELL BIO, V13, P659, DOI 10.1038/nrm3439
   Kim KH, 2013, NAT MED, V19, P83, DOI 10.1038/nm.3014
   Koyano F, 2014, NATURE, V510, P162, DOI 10.1038/nature13392
   Kujoth GC, 2005, SCIENCE, V309, P481, DOI 10.1126/science.1112125
   Kwong JQ, 2015, CELL METAB, V21, P206, DOI 10.1016/j.cmet.2014.12.001
   Lazarou M, 2015, NATURE, V524, P309, DOI 10.1038/nature14893
   Lewis P, 2007, CIRCULATION, V115, P2178, DOI 10.1161/CIRCULATIONAHA.106.664250
   Li P, 1997, CELL, V91, P479, DOI 10.1016/S0092-8674(00)80434-1
   Liao XH, 2012, CELL METAB, V15, P545, DOI 10.1016/j.cmet.2012.01.022
   Libby P, 2002, CIRCULATION, V105, P1135, DOI 10.1161/hc0902.104353
   Logan A., 2014, AGING CELL
   Madamanchi NR, 2007, CIRC RES, V100, P460, DOI 10.1161/01.RES.0000258450.44413.96
   Mercer JR, 2012, FREE RADICAL BIO MED, V52, P841, DOI 10.1016/j.freeradbiomed.2011.11.026
   Mercer JR, 2010, CIRC RES, V107, P1021, DOI 10.1161/CIRCRESAHA.110.218966
   Misawa T, 2013, NAT IMMUNOL, V14, P454, DOI 10.1038/ni.2550
   Montessuit S, 2010, CELL, V142, P889, DOI 10.1016/j.cell.2010.08.017
   Myung SK, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f10
   Narendra DP, 2010, PLOS BIOL, V8, DOI 10.1371/journal.pbio.1000298
   Nemoto S, 2005, J BIOL CHEM, V280, P16456, DOI 10.1074/jbc.M501485200
   Niessner A, 2006, CIRCULATION, V114, P2482, DOI 10.1161/CIRCULATIONAHA.106.642801
   Novak I, 2010, EMBO REP, V11, P45, DOI 10.1038/embor.2009.256
   Nunnari J, 2012, CELL, V148, P1145, DOI 10.1016/j.cell.2012.02.035
   Oka T, 2012, NATURE, V485, P251, DOI 10.1038/nature10992
   Pohjoismäki JLO, 2013, P NATL ACAD SCI USA, V110, P19408, DOI 10.1073/pnas.1303046110
   Pohjoismäki JLO, 2009, J BIOL CHEM, V284, P21446, DOI 10.1074/jbc.M109.016600
   Qiu X., 2010, CELL METAB, V12
   Rikka S, 2011, CELL DEATH DIFFER, V18, P721, DOI 10.1038/cdd.2010.146
   Rodgers JT, 2005, NATURE, V434, P113, DOI 10.1038/nature03354
   Sack M.N., 2012, Cold Spring Harb Perspect Biol, V4
   Schlicker C, 2008, J MOL BIOL, V382, P790, DOI 10.1016/j.jmb.2008.07.048
   Schrijvers DM, 2005, ARTERIOSCL THROM VAS, V25, P1256, DOI 10.1161/01.ATV.0000166517.18801.a7
   Schulz TJ, 2007, CELL METAB, V6, P280, DOI 10.1016/j.cmet.2007.08.011
   Shimada K, 2012, IMMUNITY, V36, P401, DOI 10.1016/j.immuni.2012.01.009
   Stoneman V, 2007, CIRC RES, V100, P884, DOI 10.1161/01.RES.0000260802.75766.00
   Suomalainen A, 2011, LANCET NEUROL, V10, P806, DOI 10.1016/S1474-4422(11)70155-7
   Tabas I, 2015, J CELL BIOL, V209, P13, DOI 10.1083/jcb.201412052
   Thorp E, 2009, ARTERIOSCL THROM VAS, V29, P169, DOI 10.1161/ATVBAHA.108.176495
   Trifunovic A, 2005, P NATL ACAD SCI USA, V102, P17993, DOI 10.1073/pnas.0508886102
   Trifunovic A, 2004, NATURE, V429, P417, DOI 10.1038/nature02517
   Turrens JF, 2003, J PHYSIOL-LONDON, V552, P335, DOI 10.1113/jphysiol.2003.049478
   Wallace DC, 2013, CSH PERSPECT BIOL, V5, DOI 10.1101/cshperspect.a021220
   Wang Y, 2014, CIRC RES, V114, P421, DOI 10.1161/CIRCRESAHA.114.302153
   Weber C, 2011, NAT MED, V17, P1410, DOI 10.1038/nm.2538
   West AP, 2015, NATURE, V520, P553, DOI 10.1038/nature14156
   White MJ, 2014, CELL, V159, P1549, DOI 10.1016/j.cell.2014.11.036
   Yee C, 2014, CELL, V157, P897, DOI 10.1016/j.cell.2014.02.055
   Yu E, 2013, CIRCULATION, V128, P702, DOI 10.1161/CIRCULATIONAHA.113.002271
   Yu EPK, 2014, TRENDS ENDOCRIN MET, V25, P481, DOI 10.1016/j.tem.2014.06.008
   Yu TZ, 2006, P NATL ACAD SCI USA, V103, P2653, DOI 10.1073/pnas.0511154103
   Zhang Q, 2010, NATURE, V464, P104, DOI 10.1038/nature08780
   Zhou RB, 2011, NATURE, V469, P221, DOI 10.1038/nature09663
NR 86
TC 76
Z9 80
U1 4
U2 37
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD NOV
PY 2016
VL 100
BP 223
EP 230
DI 10.1016/j.freeradbiomed.2016.06.011
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA EC3AH
UT WOS:000387995900023
PM 27320189
DA 2025-06-11
ER

PT J
AU Otte, C
   Hart, S
   Neylan, TC
   Marmar, CR
   Yaffe, K
   Mohr, DC
AF Otte, C
   Hart, S
   Neylan, TC
   Marmar, CR
   Yaffe, K
   Mohr, DC
TI A mete-analysis of cortisol response to challenge in human aging:
   importance of gender
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE HPA axis; cortisol; aging; gender; Alzheimer; depression
ID PITUITARY-ADRENAL AXIS; DEXAMETHASONE SUPPRESSION TEST;
   CORTICOTROPIN-RELEASING HORMONE; GROWTH-HORMONE; PSYCHOSOCIAL STRESS;
   ELDERLY SUBJECTS; HEALTHY-YOUNG; DEHYDROEPIANDROSTERONE-SULFATE;
   ADRENOCORTICOTROPIC HORMONE; POSTMENOPAUSAL WOMEN
AB An increased cortisol response to challenge is associated with a variety of age-related disorders such as Alzheimer's disease, depression, diabetes, metabolic syndrome, and hypertension. Among the healthy elderly, an increased cortisol response to challenge may be a risk factor for developing these age-related disorders.
   We searched Pubmed, Embase, Psychlnfo, Biosis, and Digital Dissertations (January 1966-June 2003) and included 45 parallel-group (young vs. old subjects) studies that used either a pharmacological or psychological challenge in healthy volunteers and measured cortisol response to challenge. We calculated effect sizes (Cohen's d) for the standardized mean differences between groups.
   Compared to younger controls (n = 670, mean age 28 years +/-5), older subjects (n = 625, 69 +/- 6) showed a larger cortisol response to challenge defined as stronger response to stimulation or less inhibition after a suppression test (d = 0.42, 95% confidence interval (Cl), 0.26-0.57). The effect of age on cortisol release was significantly stronger in women (d = 0.65, 95% Cl 0.34-0.97) than men (d = 0.24, 95% Cl 0.02-0.47).
   Our results demonstrate that aging increases the cortisol response to challenge. This effect of age on cortisol response is almost three-fold stronger in women than men. Prospective studies should explore whether the higher cortisol response in the elderly is a risk factor for developing neuropsychiatric and medical disorders. (C) 2004 Elsevier Ltd. All rights reserved.
C1 Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA.
   Vet Affairs Med Ctr, San Francisco, CA 94121 USA.
   Univ Hamburg, Dept Psychiat & Psychotherapy, D-20246 Hamburg, Germany.
   Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA.
   Univ Calif San Francisco, Dept Epidemiol, San Francisco, CA 94143 USA.
C3 University of California System; University of California San Francisco;
   US Department of Veterans Affairs; Veterans Health Administration (VHA);
   University of Hamburg; University of California System; University of
   California San Francisco; University of California System; University of
   California San Francisco
RP Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA.
EM otte@uke.uni-hamburg.de
RI Yaffe, Kristine/LLL-8209-2024; Hart, Stacey/E-4819-2011; Marmar,
   Charles/O-1902-2017
OI Mohr, David/0000-0002-5443-7596; Otte, Christian/0000-0002-4051-997X
CR al'Absi M, 2000, BIOMED PHARMACOTHER, V54, P234, DOI 10.1016/S0753-3322(00)80065-7
   al'Absi M, 2003, ANN BEHAV MED, V25, P25, DOI 10.1207/S15324796ABM2501_04
   Ambrosio MR, 1998, NEUROENDOCRINOLOGY, V68, P123, DOI 10.1159/000054358
   Arvat E, 1997, EUR J ENDOCRINOL, V137, P635, DOI 10.1530/eje.0.1370635
   BARON JA, 1995, J PHARMACOL EXP THER, V272, P151
   Belanoff JK, 2002, BIOL PSYCHIAT, V52, P386, DOI 10.1016/S0006-3223(02)01432-4
   BRAMBILLA F, 1994, DEPRESSION, V2, P89
   Broglio F, 2003, J CLIN ENDOCR METAB, V88, P1537, DOI 10.1210/jc.2002-021504
   BUFFINGTON CK, 1994, METABOLISM, V43, P584, DOI 10.1016/0026-0495(94)90200-3
   Cagnacci A, 1995, EUR J ENDOCRINOL, V133, P691, DOI 10.1530/eje.0.1330691
   Capuron L, 2003, AM J PSYCHIAT, V160, P1342, DOI 10.1176/appi.ajp.160.7.1342
   Cohen J., 1988, STAT POWER ANAL BEHA, DOI [10.4324/9780203771587, DOI 10.4324/9780203771587]
   COIRO V, 1989, HORM RES, V32, P119, DOI 10.1159/000181272
   Cole MG, 2003, AM J PSYCHIAT, V160, P1147, DOI 10.1176/appi.ajp.160.6.1147
   Coryell W, 2001, AM J PSYCHIAT, V158, P748, DOI 10.1176/appi.ajp.158.5.748
   De Kloet ER, 1998, ENDOCR REV, V19, P269, DOI 10.1210/er.19.3.269
   deLeon MJ, 1997, J CLIN ENDOCR METAB, V82, P3251, DOI 10.1210/jcem.82.10.4305
   DELEON MJ, 1988, LANCET, V2, P391
   Deuschle M, 1997, LIFE SCI, V61, P2239, DOI 10.1016/S0024-3205(97)00926-0
   DODT C, 1994, EUR J ENDOCRINOL, V131, P443, DOI 10.1530/eje.0.1310443
   Ershler WB, 2000, ANNU REV MED, V51, P245, DOI 10.1146/annurev.med.51.1.245
   Flint AJ, 2000, PSYCHONEUROENDOCRINO, V25, P633, DOI 10.1016/S0306-4530(00)00015-9
   Gao S, 1998, ARCH GEN PSYCHIAT, V55, P809, DOI 10.1001/archpsyc.55.9.809
   GELFIN Y, 1995, PSYCHOPHARMACOLOGY, V120, P356, DOI 10.1007/BF02311184
   Giordano R, 2001, CLIN ENDOCRINOL, V55, P259, DOI 10.1046/j.1365-2265.2001.01317.x
   GIUSTI M, 1992, ACTA ENDOCRINOL-COP, V127, P205, DOI 10.1530/acta.0.1270205
   Gold PW, 2002, MOL PSYCHIATR, V7, P254, DOI 10.1038/sj.mp.4001032
   GOTTHARDT U, 1995, AM J PHYSIOL-REG I, V268, pR865, DOI 10.1152/ajpregu.1995.268.4.R865
   GRAY A, 1991, J CLIN EPIDEMIOL, V44, P671, DOI 10.1016/0895-4356(91)90028-8
   GREENSPAN SL, 1993, J GERONTOL, V48, pM72, DOI 10.1093/geronj/48.3.M72
   HATZINGER M, 1995, NEUROBIOL AGING, V16, P205, DOI 10.1016/0197-4580(94)00159-6
   Hedges L. V., 1985, Statistical Methods for MetaAnalysis, DOI [10.1002/ev.1376, DOI 10.1016/C2009-0-03396-0]
   Herman JP, 2003, FRONT NEUROENDOCRIN, V24, P151, DOI 10.1016/j.yfrne.2003.07.001
   Heuser I, 2003, NEUROBIOL AGING, V24, pS69, DOI 10.1016/S0197-4580(03)00048-4
   HEUSER IJ, 1994, NEUROBIOL AGING, V15, P227, DOI 10.1016/0197-4580(94)90117-1
   Holsboer F, 2001, J AFFECT DISORDERS, V62, P77, DOI 10.1016/S0165-0327(00)00352-9
   HUDSON JI, 1984, ARCH GEN PSYCHIAT, V41, P1086
   JACOBSON L, 1991, ENDOCR REV, V12, P118, DOI 10.1210/edrv-12-2-118
   Kalmijn S, 1998, J CLIN ENDOCR METAB, V83, P3487, DOI 10.1210/jc.83.10.3487
   Kern W, 1996, J GERONTOL A-BIOL, V51, pM3, DOI 10.1093/gerona/51A.1.M3
   Kirschbaum C, 1996, J CLIN ENDOCR METAB, V81, P3639, DOI 10.1210/jc.81.10.3639
   KIRSCHBAUM C, 1992, LIFE SCI, V50, P435, DOI 10.1016/0024-3205(92)90378-3
   KLEY HK, 1975, ACTA ENDOCRINOL-COP, V79, P95, DOI 10.1530/acta.0.0790095
   Komesaroff PA, 1999, J CLIN ENDOCR METAB, V84, P606, DOI 10.1210/jc.84.2.606
   Krishnan KRR, 1996, BIOL PSYCHIAT, V40, P69, DOI 10.1016/0006-3223(95)00424-6
   Kudielka BM, 1999, NEUROENDOCRINOLOGY, V70, P422, DOI 10.1159/000054504
   Kudielka BM, 2004, PSYCHONEUROENDOCRINO, V29, P83, DOI 10.1016/S0306-4530(02)00146-4
   Kudielka BM, 1998, J CLIN ENDOCR METAB, V83, P1756, DOI 10.1210/jc.83.5.1756
   Lamberts SWJ, 1997, SCIENCE, V278, P419, DOI 10.1126/science.278.5337.419
   Lauer CJ, 1998, J PSYCHIAT RES, V32, P393, DOI 10.1016/S0022-3956(98)00026-0
   Laughlin GA, 2000, J CLIN ENDOCR METAB, V85, P3561, DOI 10.1210/jc.85.10.3561
   LAWLOR BA, 1989, PSYCHIAT RES, V29, P1, DOI 10.1016/0165-1781(89)90181-9
   LINDHEIM SR, 1992, AM J OBSTET GYNECOL, V167, P1831, DOI 10.1016/0002-9378(92)91783-7
   Lipsey MW., 2001, Practical meta-analysis
   Lupien SJ, 1999, REV NEUROSCIENCE, V10, P117
   Lupien SJ, 1998, NAT NEUROSCI, V1, P69, DOI 10.1038/271
   Marker JC, 1998, AM J PHYSIOL-ENDOC M, V275, pE770, DOI 10.1152/ajpendo.1998.275.5.E770
   MARKER JC, 1992, DIABETES, V41, P671, DOI 10.2337/diabetes.41.6.671
   Martínez-Taboada V, 2002, MECH AGEING DEV, V123, P1477, DOI 10.1016/S0047-6374(02)00116-1
   McEwen BS, 2002, NEUROBIOL AGING, V23, P921, DOI 10.1016/S0197-4580(02)00027-1
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   MEANEY MJ, 1995, EXP GERONTOL, V30, P229, DOI 10.1016/0531-5565(94)00065-B
   MENEILLY GS, 1985, J CLIN ENDOCR METAB, V61, P178, DOI 10.1210/jcem-61-1-178
   MILLER AH, 1994, AM J PSYCHIAT, V151, P267
   MORIMOTO S, 1980, J AM GERIATR SOC, V28, P361, DOI 10.1111/j.1532-5415.1980.tb01099.x
   MUGGEO M, 1975, J GERONTOL, V30, P546, DOI 10.1093/geronj/30.5.546
   NASMAN B, 1995, PSYCHONEUROENDOCRINO, V20, P211, DOI 10.1016/0306-4530(94)00054-E
   Nichols NR, 1998, INTERD T GERONT GERI, V29, P1
   Nicolson N, 1997, J GERONTOL A-BIOL, V52, pM68, DOI 10.1093/gerona/52A.2.M68
   OBrien JT, 1996, BRIT J PSYCHIAT, V168, P679, DOI 10.1192/bjp.168.6.679
   OHASHI M, 1986, GERONTOLOGY, V32, P43, DOI 10.1159/000212764
   ORTIZALONSO FJ, 1994, AM J PHYSIOL-ENDOC M, V267, pE497, DOI 10.1152/ajpendo.1994.267.4.E497
   Otte C, 2003, J GERONTOL A-BIOL, V58, P900, DOI 10.1093/gerona/58.10.B900
   Otte C, 2003, LIFE SCI, V73, P1835, DOI 10.1016/S0024-3205(03)00513-7
   OXENKRUG GF, 1983, PSYCHIAT RES, V10, P125, DOI 10.1016/0165-1781(83)90111-7
   Parker CR, 2000, J CLIN ENDOCR METAB, V85, P48, DOI 10.1210/jc.85.1.48
   Pascualy M, 2000, BIOL PSYCHIAT, V48, P247, DOI 10.1016/S0006-3223(00)00879-9
   PAVLOV EP, 1986, J CLIN ENDOCR METAB, V62, P767, DOI 10.1210/jcem-62-4-767
   Pedersen WA, 2001, MECH AGEING DEV, V122, P963, DOI 10.1016/S0047-6374(01)00250-0
   Perras B, 1999, PSYCHONEUROENDOCRINO, V24, P743, DOI 10.1016/S0306-4530(99)00027-X
   Peskind ER, 2001, NEUROLOGY, V56, P1094, DOI 10.1212/WNL.56.8.1094
   PESKIND ER, 1995, J GERONTOL A-BIOL, V50, pM114, DOI 10.1093/gerona/50A.2.M114
   Pickworth WB, 1998, PSYCHONEUROENDOCRINO, V23, P131, DOI 10.1016/S0306-4530(97)00075-9
   Pomara N, 2002, NEUROLOGY, V58, P1436, DOI 10.1212/WNL.58.9.1436
   PONTIROLI AE, 1992, J ENDOCRINOL INVEST, V15, P559, DOI 10.1007/BF03344925
   Raff H, 1999, J GERONTOL A-BIOL, V54, pM479, DOI 10.1093/gerona/54.9.M479
   RAO RH, 1987, METABOLISM, V36, P658, DOI 10.1016/0026-0495(87)90150-8
   RASKIND M, 1982, AM J PSYCHIAT, V139, P1468
   RASKIND MA, 1990, J CLIN ENDOCR METAB, V70, P1420, DOI 10.1210/jcem-70-5-1420
   RASKIND MA, 1995, PSYCHONEUROENDOCRINO, V20, P637, DOI 10.1016/0306-4530(95)00004-8
   RASKIND MA, 1994, ANN NY ACAD SCI, V746, P327
   Rasmuson S, 1998, BIOL PSYCHIAT, V43, P401, DOI 10.1016/S0006-3223(97)00283-7
   Reynolds RM, 2001, J CLIN ENDOCR METAB, V86, P245, DOI 10.1210/jc.86.1.245
   Reynolds RM, 2003, METABOLISM, V52, P524, DOI 10.1053/meta.2003.50090
   RIBEIRO SCM, 1993, AM J PSYCHIAT, V150, P1618
   Rohleder N, 2002, J NEUROIMMUNOL, V126, P69, DOI 10.1016/S0165-5728(02)00062-0
   Rosenthal R., 1994, The Handbook of Research Synthesis, V621, P231
   Rosmond R, 1998, J CLIN ENDOCR METAB, V83, P1853, DOI 10.1210/jc.83.6.1853
   Rothschild AJ, 2003, PSYCHONEUROENDOCRINOLOGY: SCIENTIFIC BASIS OF CLINICAL PRACTICE, P139
   Rubin RT, 2002, NEUROPSYCHOPHARMACOL, V26, P672, DOI 10.1016/S0893-133X(01)00376-1
   SAPOLSKY RM, 1986, ENDOCR REV, V7, P284, DOI 10.1210/edrv-7-3-284
   Sapolsky RM, 2000, ENDOCR REV, V21, P55, DOI 10.1210/er.21.1.55
   Sapolsky RM, 1999, EXP GERONTOL, V34, P721, DOI 10.1016/S0531-5565(99)00047-9
   Schaaf M J, 2000, Stress, V3, P201, DOI 10.3109/10253890009001124
   Seeman TE, 2001, P NATL ACAD SCI USA, V98, P4770, DOI 10.1073/pnas.081072698
   SEEMAN TE, 1994, ENDOCR REV, V15, P233, DOI 10.1210/er.15.2.233
   STUCK AE, 1988, CLIN PHARMACOL THER, V43, P354, DOI 10.1038/clpt.1988.43
   Swanwick GRJ, 1996, BIOL PSYCHIAT, V39, P976, DOI 10.1016/0006-3223(95)00590-0
   TARGUM SD, 1983, AM J PSYCHIAT, V140, P877
   TOURIGNYRIVARD MF, 1981, BIOL PSYCHIAT, V16, P1177
   *UN, 2003, DEP EC SOC AFF
   Van Cauter E, 2000, JAMA-J AM MED ASSOC, V284, P861, DOI 10.1001/jama.284.7.861
   VanCauter E, 1996, J CLIN ENDOCR METAB, V81, P2468, DOI 10.1210/jc.81.7.2468
   Vgontzas AN, 2003, J CLIN ENDOCR METAB, V88, P2087, DOI 10.1210/jc.2002-021176
   Vgontzas AN, 2001, J CLIN ENDOCR METAB, V86, P1489, DOI 10.1210/jc.86.4.1489
   Viau V, 1996, J NEUROSCI, V16, P1866
   Vieta E, 1997, ACTA PSYCHIAT SCAND, V95, P205, DOI 10.1111/j.1600-0447.1997.tb09621.x
   WALTMAN C, 1991, J CLIN ENDOCR METAB, V73, P495, DOI 10.1210/jcem-73-3-495
   Wolf OT, 2002, NEUROENDOCRINOLOGY, V75, P241, DOI 10.1159/000054715
   Wolkowitz O M, 2001, World J Biol Psychiatry, V2, P115
   Yaffe K, 2003, NEUROLOGY, V61, P76, DOI 10.1212/01.WNL.0000073620.42047.D7
   Yen SSC, 1998, EXP GERONTOL, V33, P897, DOI 10.1016/S0531-5565(98)00046-1
   Zobel AW, 2001, J PSYCHIAT RES, V35, P83, DOI 10.1016/S0022-3956(01)00013-9
NR 123
TC 304
Z9 342
U1 0
U2 27
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JAN
PY 2005
VL 30
IS 1
BP 80
EP 91
DI 10.1016/j.psyneuen.2004.06.002
PG 12
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 858TL
UT WOS:000224214700009
PM 15358445
DA 2025-06-11
ER

PT J
AU Tao, LC
   Shi, J
   Yang, XY
   Yang, L
   Hua, F
AF Tao, Lichan
   Shi, Jia
   Yang, Xiaoyu
   Yang, Ling
   Hua, Fei
TI The Exosome: a New Player in Diabetic Cardiomyopathy
SO JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
LA English
DT Review
DE Exosomes; Diabetic cardiomyopathy
ID EXTRACELLULAR VESICLES; OXIDATIVE STRESS; DENDRITIC CELLS;
   MICROVESICLES; EXERCISE; CARDIOMYOCYTES; BIOMARKERS; MICRORNAS;
   INTERVENTION; ANGIOGENESIS
AB Diabetic cardiomyopathy (DCM) or diabetes-induced cardiac dysfunction is a direct consequence of uncontrolled metabolic syndrome and occurs worldwide. However, the underlying cellular and molecular mechanisms remain poorly understood. Recently, exosomes have attracted considerable interest for their use as efficient, targeted, and non-immunogenic delivery systems for biological molecules or pharmacotherapies. This review will summarize the fast-developing field of the regulation and function of exosomes in DCM, affording valuable insights and therapeutic opportunities in combatting diabetes-related cardiac disorder for modern human health.
C1 [Tao, Lichan; Yang, Xiaoyu; Yang, Ling] Soochow Univ, Affiliated Hosp 3, Dept Cardiol, Changzhou City 213003, Peoples R China.
   [Shi, Jia] Soochow Univ, Affiliated Hosp 3, Dept Neurosurg, Changzhou City 213003, Peoples R China.
   [Hua, Fei] Soochow Univ, Affiliated Hosp 3, Dept Endocrinol, Changzhou City 213003, Peoples R China.
C3 Soochow University - China; Soochow University - China; Soochow
   University - China
RP Yang, L (corresponding author), Soochow Univ, Affiliated Hosp 3, Dept Cardiol, Changzhou City 213003, Peoples R China.; Hua, F (corresponding author), Soochow Univ, Affiliated Hosp 3, Dept Endocrinol, Changzhou City 213003, Peoples R China.
EM jsczyangling@163.com; czhuafei@vip.sina.com
RI Yang, Xiaoyu/AAJ-4203-2021; TAO, Li/HIR-4254-2022; Hua,
   Fei/AAT-2677-2020
FU National Natural Science Foundation of China [81700343]; Natural Science
   Foundation of Jiangsu Province of China [BK20170296]; Changzhou
   High-Level Medical Talents Training Project [2016ZCLJ020]
FX This work was supported by the grants from National Natural Science
   Foundation of China (81700343 to Lichan Tao), Natural Science Foundation
   of Jiangsu Province of China (BK20170296 to Lichan Tao), and Changzhou
   High-Level Medical Talents Training Project (2016ZCLJ020 to Fei Hua).
CR [Anonymous], J CIRC BIOMARK
   Arslan F, 2013, STEM CELL RES, V10, P301, DOI 10.1016/j.scr.2013.01.002
   Aurelian SM, 2014, ROM J MORPHOL EMBRYO, V55, P1035
   Bei YH, 2017, ADV EXP MED BIOL, V998, P255, DOI 10.1007/978-981-10-4397-0_17
   Brisson AR, 2017, PLATELETS, V28, P263, DOI 10.1080/09537104.2016.1268255
   Bugger H, 2014, DIABETOLOGIA, V57, P660, DOI 10.1007/s00125-014-3171-6
   Chaturvedi P, 2015, J CELL MOL MED, V19, P2153, DOI 10.1111/jcmm.12589
   Chistiakov DA, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17010063
   Costantino S, 2016, EUR HEART J, V37, P572, DOI 10.1093/eurheartj/ehv599
   Davidson SM, 2018, J CELL MOL MED, V22, P141, DOI 10.1111/jcmm.13302
   Deddens JC, 2016, J CARDIOVASC TRANSL, V9, P291, DOI 10.1007/s12265-016-9705-1
   Denzer K, 2000, J IMMUNOL, V165, P1259, DOI 10.4049/jimmunol.165.3.1259
   Harcourt BE, 2013, NAT REV ENDOCRINOL, V9, P113, DOI 10.1038/nrendo.2012.236
   Huang-Doran I, 2017, TRENDS ENDOCRIN MET, V28, P3, DOI 10.1016/j.tem.2016.10.003
   Hulsmans M, 2013, CARDIOVASC RES, V100, P7, DOI 10.1093/cvr/cvt161
   Johnstone RM, 2005, BLOOD CELL MOL DIS, V34, P214, DOI 10.1016/j.bcmd.2005.03.002
   Joshi M, 2014, MOL CELL BIOCHEM, V386, P233, DOI 10.1007/s11010-013-1861-x
   Khanra R, 2015, J TRANSL MED, V13, DOI 10.1186/s12967-014-0364-1
   Kowal J, 2016, P NATL ACAD SCI USA, V113, pE968, DOI 10.1073/pnas.1521230113
   Lai RC, 2010, STEM CELL RES, V4, P214, DOI 10.1016/j.scr.2009.12.003
   Lawson C, 2016, J ENDOCRINOL, V228, pR57, DOI 10.1530/JOE-15-0201
   Lu MM, 2019, J CARDIOVASC TRANSL, V12, P68, DOI 10.1007/s12265-018-9796-y
   Miki T, 2013, HEART FAIL REV, V18, P149, DOI 10.1007/s10741-012-9313-3
   Montecalvo A, 2012, BLOOD, V119, P756, DOI 10.1182/blood-2011-02-338004
   Müller G, 2012, DIABET METAB SYND OB, V5, P247, DOI 10.2147/DMSO.S32923
   Ni J., 2018, J CARDIOVASCULAR TRA
   Ouwens DM, 2005, DIABETOLOGIA, V48, P1229, DOI 10.1007/s00125-005-1755-x
   Pan Y, 2014, DIABETES, V63, P3497, DOI 10.2337/db13-1577
   Raposo G, 2013, J CELL BIOL, V200, P373, DOI 10.1083/jcb.201211138
   Sacre JW, 2014, METABOLISM, V63, P1104, DOI 10.1016/j.metabol.2014.05.007
   Safdar A, 2016, NAT REV ENDOCRINOL, V12, P504, DOI 10.1038/nrendo.2016.76
   Shi RJ, 2017, BIOCHEM BIOPH RES CO, V483, P602, DOI 10.1016/j.bbrc.2016.12.097
   Siamilis S, 2009, SPINAL CORD, V47, P453, DOI 10.1038/sc.2008.125
   Staiano AE, 2017, J SPORT HEALTH SCI, V6, P4, DOI 10.1016/j.jshs.2016.11.005
   Thery Clotilde, 2011, F1000 Biol Rep, V3, P15, DOI 10.3410/B3-15
   TRAMS EG, 1981, BIOCHIM BIOPHYS ACTA, V645, P63, DOI 10.1016/0005-2736(81)90512-5
   Valadi H, 2007, NAT CELL BIOL, V9, P654, DOI 10.1038/ncb1596
   Wan A, 2016, CARDIOVASC RES, V111, P172, DOI 10.1093/cvr/cvw159
   Wang H, 2015, CELL PHYSIOL BIOCHEM, V35, P2159, DOI 10.1159/000374021
   Wang XH, 2016, DIABETES, V65, P3111, DOI 10.2337/db15-1563
   Wang XH, 2014, J MOL CELL CARDIOL, V74, P139, DOI 10.1016/j.yjmcc.2014.05.001
   Williams SA, 1998, J MOL CELL CARDIOL, V30, P109, DOI 10.1006/jmcc.1997.0576
   Xu R, 2016, J CLIN INVEST, V126, P1152, DOI 10.1172/JCI81129
   Yu B, 2015, INT J CARDIOL, V182, P349, DOI 10.1016/j.ijcard.2014.12.043
   Zomer A, 2016, NAT PROTOC, V11, P87, DOI 10.1038/nprot.2015.138
NR 45
TC 19
Z9 21
U1 4
U2 39
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1937-5387
EI 1937-5395
J9 J CARDIOVASC TRANSL
JI J. Cardiovasc. Transl. Res.
PD FEB
PY 2019
VL 12
IS 1
SI SI
BP 62
EP 67
DI 10.1007/s12265-018-9825-x
PG 6
WC Cardiac & Cardiovascular Systems; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Research & Experimental Medicine
GA HM4JH
UT WOS:000459439000009
PM 30251219
DA 2025-06-11
ER

PT J
AU Malin, SK
   Braun, B
AF Malin, Steven K.
   Braun, Barry
TI Impact of Metformin on Exercise-Induced Metabolic Adaptations to Lower
   Type 2 Diabetes Risk
SO EXERCISE AND SPORT SCIENCES REVIEWS
LA English
DT Review
DE obesity; prediabetes; type 2 diabetes; insulin resistance; metabolic
   syndrome; lifestyle modification
ID IMPAIRED GLUCOSE-TOLERANCE; LIFE-STYLE INTERVENTION; AEROBIC EXERCISE;
   CARDIOVASCULAR-DISEASE; INSULIN SENSITIVITY; DOUBLE-BLIND;
   SUPPLEMENTATION; INDIVIDUALS; ASSOCIATION; ADOLESCENTS
AB Combining metformin with exercise has been proposed to improve glucose homeostasis. However, we primarily discuss evidence suggesting that metformin and other pharmacological agents/dietary supplements (e.g., statins, resveratol, or antioxidants) may in fact oppose exercise-induced benefits on insulin sensitivity and cardiometabolic health. We explore the novel hypothesis that attenuation of oxidative stress from exercise by these exogenous compounds blunts metabolic adaptation.
C1 [Malin, Steven K.] Univ Virginia, Dept Kinesiol, Charlottesville, VA 22904 USA.
   [Malin, Steven K.] Univ Virginia, Div Endocrinol & Metab, Charlottesville, VA USA.
   [Braun, Barry] Colorado State Univ, Dept Hlth & Exercise Sci, Ft Collins, CO 80523 USA.
C3 University of Virginia; University of Virginia; Colorado State
   University System; Colorado State University Fort Collins
RP Malin, SK (corresponding author), Univ Virginia, Dept Kinesiol, 225A Mem Gymnasium, Charlottesville, VA 22904 USA.
EM skm6n@virginia.edu
RI Malin, Steven/IXX-0225-2023
OI Malin, Steven/0000-0002-7360-6711
FU Pfizer, Inc.; NIH [5R56 DK081038]; ADA [7-04-JF-10]; ACSM Doctoral
   Student Foundation [S17100000000113]
FX The authors thank Carrie G. Sharoff, Ph.D., Todd A. Hagobian, Ph.D.,
   Stuart R. Chipkin, M.D., Brooke R. Stephens, Ph.D., Rebecca E. Hasson,
   Ph.D., Kirsten Granados, M.S., Richard Viskochil, M.S., Jennifer Rivero,
   M.S., and Robert Gerber, M.S., for outstanding support. We extend our
   appreciation to all the dedicated participants and undergraduate
   research assistants for their help. B. Braun receives consultant fees
   and research funding from Pfizer, Inc. This research was supported by
   NIH 5R56 DK081038 (B. Braun), ADA 7-04-JF-10 (B. Braun), and an ACSM
   Doctoral Student Foundation Grant S17100000000113 (S.K. Malin).
CR Andreadis EA, 2009, EXP CLIN ENDOCR DIAB, V117, P175, DOI 10.1055/s-0028-1087177
   [Anonymous], 2005, NAT DIAB FACT SHEET
   Boulé NG, 2013, DIABETOLOGIA, V56, P2378, DOI 10.1007/s00125-013-3026-6
   Boulé NG, 2011, DIABETES CARE, V34, P1469, DOI 10.2337/dc10-2207
   Braun B, 2008, APPL PHYSIOL NUTR ME, V33, P61, DOI 10.1139/H07-144
   Brunmair B, 2004, DIABETES, V53, P1052, DOI 10.2337/diabetes.53.4.1052
   Cadeddu C, 2014, CARDIOVASC DIABETOL, V13, DOI 10.1186/1475-2840-13-93
   Clarson CL, 2009, ENDOCRINE, V36, P141, DOI 10.1007/s12020-009-9196-9
   Eshghi SRT, 2013, CAN J DIABETES, V37, P375, DOI 10.1016/j.jcjd.2013.07.030
   Gliemann L, 2013, J PHYSIOL-LONDON, V591, P5047, DOI 10.1113/jphysiol.2013.258061
   Jadhav S, 2006, J AM COLL CARDIOL, V48, P956, DOI 10.1016/j.jacc.2006.04.088
   Jenkins NT, 2012, J APPL PHYSIOL, V113, P1873, DOI 10.1152/japplphysiol.00936.2012
   Knowler William C, 2002, N Engl J Med, V346, P393, DOI 10.1056/NEJMoa012512
   Kraus WE, 2009, OBESITY, V17, pS21, DOI 10.1038/oby.2009.384
   Lehtovirta M, 2001, DIABETIC MED, V18, P578, DOI 10.1046/j.1464-5491.2001.00539.x
   Linden MA, 2014, AM J PHYSIOL-ENDOC M, V306, pE300, DOI 10.1152/ajpendo.00427.2013
   Love-Osborne K, 2008, J PEDIATR, V152, P817, DOI 10.1016/j.jpeds.2008.01.018
   Malin SK, 2012, DIABETES OBES METAB, V14, P835, DOI 10.1111/j.1463-1326.2012.01608.x
   Malin SK, 2014, CURR OPIN ENDOCRINOL, V21, P323, DOI 10.1097/MED.0000000000000095
   Malin SK, 2013, APPL PHYSIOL NUTR ME, V38, P427, DOI 10.1139/apnm-2012-0433
   Malin SK, 2013, OBESITY, V21, P93, DOI 10.1002/oby.20235
   Malin SK, 2012, DIABETES CARE, V35, P131, DOI 10.2337/dc11-0925
   Malin SK, 2010, INT J SPORT NUTR EXE, V20, P63, DOI 10.1123/ijsnem.20.1.63
   Mauras N, 2012, J PEDIATR ENDOCR MET, V25, P33, DOI 10.1515/jpem-2011-0450
   Mikus CR, 2013, J AM COLL CARDIOL, V62, P709, DOI 10.1016/j.jacc.2013.02.074
   Miller RA, 2013, NATURE, V494, P256, DOI 10.1038/nature11808
   Ortega JF, 2014, ACTA DIABETOL, V51, P749, DOI 10.1007/s00592-014-0580-4
   Paulsen G, 2014, J PHYSIOL-LONDON, V592, P1887, DOI 10.1113/jphysiol.2013.267419
   Pollak M, 2012, CLIN CANCER RES, V18, P2723, DOI 10.1158/1078-0432.CCR-12-0694
   Ramachandran A, 2006, DIABETOLOGIA, V49, P289, DOI 10.1007/s00125-005-0097-z
   Rhee MK, 2010, DIABETES CARE, V33, P49, DOI 10.2337/dc09-0341
   Sharoff CG, 2010, AM J PHYSIOL-ENDOC M, V298, pE815, DOI 10.1152/ajpendo.00517.2009
   Viollet B, 2012, CLIN SCI, V122, P253, DOI 10.1042/CS20110386
   Wei M, 1999, ANN INTERN MED, V130, P89, DOI 10.7326/0003-4819-130-2-199901190-00002
   Yfanti C, 2011, AM J PHYSIOL-ENDOC M, V300, pE761, DOI 10.1152/ajpendo.00207.2010
NR 35
TC 44
Z9 46
U1 0
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0091-6331
EI 1538-3008
J9 EXERC SPORT SCI REV
JI Exerc. Sport Sci. Rev.
PD JAN
PY 2016
VL 44
IS 1
BP 4
EP 11
DI 10.1249/JES.0000000000000070
PG 8
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA CY9HO
UT WOS:000366718200004
PM 26583801
DA 2025-06-11
ER

PT J
AU Yu, EPK
   Bennett, MR
AF Yu, Emma P. K.
   Bennett, Martin R.
TI Mitochondrial DNA damage and atherosclerosis
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE mitochondria; atherosclerosis; inflammation
ID PERMEABILITY TRANSITION PORE; SMOOTH-MUSCLE-CELLS; OXIDATIVE STRESS;
   INFLAMMASOME ACTIVATION; NLRP3 INFLAMMASOME; METABOLIC SYNDROME; MTDNA
   MUTATIONS; APOPTOSIS; MICE; ATHEROGENESIS
AB Mitochondria are often regarded as the cellular powerhouses through their ability to generate ATP, the universal fuel for metabolic processes. However, in recent years mitochondria have been recognised as critical regulators of cell death, inflammation, metabolism, and the generation of reactive oxygen species (ROS). Thus, mitochondrial dysfunction directly promotes cell death, inflammation, and oxidative stress and alters metabolism. These are key processes in atherosclerosis and there is now evidence that mitochondrial DNA (mtDNA) damage leads to mitochondrial dysfunction and promotes atherosclerosis directly. In this review we discuss the recent evidence for and mechanisms linking mtDNA defects and atherosclerosis and suggest areas of mitochondrial biology that are potential therapeutic targets.
C1 [Yu, Emma P. K.; Bennett, Martin R.] Univ Cambridge, Addenbrookes Hosp, Addenbrookes Ctr Clin Invest, Div Cardiovasc Med, Cambridge CB2 2QQ, England.
C3 Cambridge University Hospitals NHS Foundation Trust; Addenbrooke's
   Hospital; University of Cambridge
RP Yu, EPK (corresponding author), Univ Cambridge, Addenbrookes Hosp, Addenbrookes Ctr Clin Invest, Div Cardiovasc Med, Box 110, Cambridge CB2 2QQ, England.
EM epky2@cam.ac.uk
OI Bennett, Martin/0000-0002-2565-1825
FU Medical Research Council [G0800784, G1000847] Funding Source: Medline;
   MRC [G1000847, G0800784] Funding Source: UKRI
CR Ballinger SW, 2002, CIRCULATION, V106, P544, DOI 10.1161/01.CIR.0000023921.93743.89
   Bernardi P, 2013, FRONT PHYSIOL, V4, DOI 10.3389/fphys.2013.00095
   Botto N, 2005, MUTAT RES-FUND MOL M, V570, P81, DOI 10.1016/j.mrfmmm.2004.10.003
   Bratic A, 2013, J CLIN INVEST, V123, P951, DOI 10.1172/JCI64125
   Chen HC, 2010, CELL, V141, P280, DOI 10.1016/j.cell.2010.02.026
   Chen Y, 2013, SCIENCE, V340, P471, DOI 10.1126/science.1231031
   Chu CT, 2013, NAT CELL BIOL, V15, P1197, DOI 10.1038/ncb2837
   Clarke MCH, 2008, CIRC RES, V102, P1529, DOI 10.1161/CIRCRESAHA.108.175976
   Clarke MCH, 2006, NAT MED, V12, P1075, DOI 10.1038/nm1459
   Cochemé HM, 2012, NAT PROTOC, V7, P946, DOI 10.1038/nprot.2012.035
   CORRALDEBRINSKI M, 1992, MUTAT RES, V275, P169, DOI 10.1016/0921-8734(92)90021-G
   Dai DF, 2010, AGING CELL, V9, P536, DOI 10.1111/j.1474-9726.2010.00581.x
   Du XL, 2000, P NATL ACAD SCI USA, V97, P12222, DOI 10.1073/pnas.97.22.12222
   Duewell P, 2010, NATURE, V464, P1357, DOI 10.1038/nature08938
   Freigang S, 2013, NAT IMMUNOL, V14, P1045, DOI 10.1038/ni.2704
   Frezza C, 2006, CELL, V126, P177, DOI 10.1016/j.cell.2006.06.025
   Geisler S, 2010, NAT CELL BIOL, V12, P119, DOI 10.1038/ncb2012
   Giorgio V, 2013, P NATL ACAD SCI USA, V110, P5887, DOI 10.1073/pnas.1217823110
   Gorenne I, 2006, CARDIOVASC RES, V72, P9, DOI 10.1016/j.cardiores.2006.06.004
   Halestrap AP, 2004, CARDIOVASC RES, V61, P372, DOI 10.1016/S0008-6363(03)00533-9
   Hansson GK, 2011, NAT IMMUNOL, V12, P204, DOI 10.1038/ni.2001
   Hardie DG, 2012, NAT REV MOL CELL BIO, V13, P251, DOI 10.1038/nrm3311
   HARMAN D, 1972, J AM GERIATR SOC, V20, P145, DOI 10.1111/j.1532-5415.1972.tb00787.x
   Hiona A, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011468
   Hoppins S, 2012, SCIENCE, V337, P1052, DOI 10.1126/science.1224709
   Hotta Y, 2009, ENDOCRINOLOGY, V150, P4625, DOI 10.1210/en.2009-0119
   Ishihara N, 2009, NAT CELL BIOL, V11, P958, DOI 10.1038/ncb1907
   Iyer SS, 2013, IMMUNITY, V39, P311, DOI 10.1016/j.immuni.2013.08.001
   Kim KH, 2013, NAT MED, V19, P83, DOI 10.1038/nm.3014
   Kujoth GC, 2005, SCIENCE, V309, P481, DOI 10.1126/science.1112125
   Larsson NG, 2010, ANNU REV BIOCHEM, V79, P683, DOI 10.1146/annurev-biochem-060408-093701
   Logan A., 2014, AGING CELL
   Madamanchi NR, 2005, ARTERIOSCL THROM VAS, V25, P950, DOI 10.1161/01.ATV.0000161050.77646.68
   Mariño G, 2014, NAT REV MOL CELL BIO, V15, P81, DOI 10.1038/nrm3735
   Mercer JR, 2012, FREE RADICAL BIO MED, V52, P841, DOI 10.1016/j.freeradbiomed.2011.11.026
   Mercer JR, 2010, CIRC RES, V107, P1021, DOI 10.1161/CIRCRESAHA.110.218966
   Nakahira K, 2011, NAT IMMUNOL, V12, P222, DOI 10.1038/ni.1980
   Nunnari J, 2012, CELL, V148, P1145, DOI 10.1016/j.cell.2012.02.035
   Oka T, 2012, NATURE, V485, P251, DOI 10.1038/nature10992
   Ong SB, 2010, CIRCULATION, V121, P2012, DOI 10.1161/CIRCULATIONAHA.109.906610
   Salminen A, 2012, CELL MOL LIFE SCI, V69, P2999, DOI 10.1007/s00018-012-0962-0
   Sarraf SA, 2013, NATURE, V496, P372, DOI 10.1038/nature12043
   Schinzel AC, 2005, P NATL ACAD SCI USA, V102, P12005, DOI 10.1073/pnas.0505294102
   Shimada K, 2012, IMMUNITY, V36, P401, DOI 10.1016/j.immuni.2012.01.009
   Stocker R, 2004, PHYSIOL REV, V84, P1381, DOI 10.1152/physrev.00047.2003
   Stoneman V, 2007, CIRC RES, V100, P884, DOI 10.1161/01.RES.0000260802.75766.00
   Subramanian N, 2013, CELL, V153, P348, DOI 10.1016/j.cell.2013.02.054
   Suomalainen A, 2011, LANCET NEUROL, V10, P806, DOI 10.1016/S1474-4422(11)70155-7
   Thorp E, 2009, ARTERIOSCL THROM VAS, V29, P169, DOI 10.1161/ATVBAHA.108.176495
   Torzewski M, 2007, ARTERIOSCL THROM VAS, V27, P850, DOI 10.1161/01.ATV.0000258809.47285.07
   Trifunovic A, 2005, P NATL ACAD SCI USA, V102, P17993, DOI 10.1073/pnas.0508886102
   Trifunovic A, 2004, NATURE, V429, P417, DOI 10.1038/nature02517
   Turrens JF, 2003, J PHYSIOL-LONDON, V552, P335, DOI 10.1113/jphysiol.2003.049478
   Tyynismaa H, 2010, HUM MOL GENET, V19, P3948, DOI 10.1093/hmg/ddq310
   Vaseva AV, 2012, CELL, V149, P1536, DOI 10.1016/j.cell.2012.05.014
   Vendrov AE, 2007, ARTERIOSCL THROM VAS, V27, P2714, DOI 10.1161/ATVBAHA.107.152629
   Wang Y, 2014, CIRC RES, V114, P421, DOI 10.1161/CIRCRESAHA.114.302153
   Weber C, 2011, NAT MED, V17, P1410, DOI 10.1038/nm.2538
   Weissberg PL, 2000, HEART, V83, P247, DOI 10.1136/heart.83.2.247
   Whelan RS, 2012, P NATL ACAD SCI USA, V109, P6566, DOI 10.1073/pnas.1201608109
   Yu E, 2013, CIRCULATION, V128, P702, DOI 10.1161/CIRCULATIONAHA.113.002271
   Zhang Q, 2010, NATURE, V464, P104, DOI 10.1038/nature08780
   Zhou RB, 2011, NATURE, V469, P221, DOI 10.1038/nature09663
NR 63
TC 108
Z9 120
U1 4
U2 40
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD SEP
PY 2014
VL 25
IS 9
BP 481
EP 487
DI 10.1016/j.tem.2014.06.008
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AO8OD
UT WOS:000341612900007
PM 25034130
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Dallman, MF
   Akana, SF
   Bhatnagar, S
   Bell, ME
   Strack, AM
AF Dallman, MF
   Akana, SF
   Bhatnagar, S
   Bell, ME
   Strack, AM
TI Bottomed out: metabolic significance of the circadian trough in
   glucocorticoid concentrations
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article; Proceedings Paper
CT 8th International Congress on Endocrinology of Obesity Basic, Clinical
   and Therapeutic Aspects
CY SEP, 1998
CL VENICE, ITALY
DE HPA axis; feedback; MR; GR; insulin; obesity; fat stores; food intake
ID PITUITARY-ADRENAL AXIS; CORTICOTROPIN-RELEASING HORMONE; MAJOR
   DEPRESSIVE-ILLNESS; CLINICAL RESEARCH-CENTER; CORTISOL SECRETION;
   ANOREXIA-NERVOSA; EXOGENOUS CORTICOSTERONE; FAT DISTRIBUTION; CHRONIC
   STRESS; DIABETIC RATS
AB Mild chronic stressors characteristically increase circadian trough corticosteroid concentrations in rats and man. The elevation in trough concentrations is often accompanied by a reduction in peak concentrations and no change in the dairy mean values. Here we point out that elevation of trough glucocorticoids, probably through daily increases of glucocorticoid receptor occupancy, has major metabolic effects that bias organisms toward storage of calories as fat. Thus. chronic mild stress, by overriding the normal mineralocorticoid receptor-mediated corticosteroid feedback regulation of trough CRF and ACTH secretion, facilitates development of the metabolic syndrome.
C1 Univ Calif San Francisco, Sch Med, Dept Physiol, San Francisco, CA 94143 USA.
   Merck & Co, Dept Pharmacol, Rahway, NJ 07065 USA.
C3 University of California System; University of California San Francisco;
   Merck & Company
RP Dallman, MF (corresponding author), Univ Calif San Francisco, Sch Med, Dept Physiol, San Francisco, CA 94143 USA.
RI Dallman, Mary/B-4816-2010; Bhatnagar, Seema/M-7110-2017
FU NIDDK NIH HHS [DK28172] Funding Source: Medline
CR AKANA SF, 1992, ENDOCRINOLOGY, V131, P585, DOI 10.1210/en.131.2.585
   Akana SF, 1997, ENDOCRINOLOGY, V138, P3249, DOI 10.1210/en.138.8.3249
   AKANA SF, 1986, ENDOCRINOLOGY, V119, P2325, DOI 10.1210/endo-119-5-2325
   [Anonymous], 1977, NEW ENGL J MED
   Bhatnagar S, 1998, NEUROSCIENCE, V84, P1025, DOI 10.1016/S0306-4522(97)00577-0
   BILLER BMK, 1990, J CLIN ENDOCR METAB, V70, P311, DOI 10.1210/jcem-70-2-311
   BRADBURY MJ, 1994, ENDOCRINOLOGY, V134, P1286, DOI 10.1210/en.134.3.1286
   BRINDLEY DN, 1989, CLIN SCI, V77, P453, DOI 10.1042/cs0770453
   CELLA LK, 1995, AM J PHYSIOL-ENDOC M, V269, pE489, DOI 10.1152/ajpendo.1995.269.3.E489
   Dallman M. F., 1989, CONTROL HYPOTHALAMO, P95
   DALLMAN MF, 1989, ENDOCRINOLOGY, V124, P2844, DOI 10.1210/endo-124-6-2844
   DALLMAN MF, 1987, RECENT PROG HORM RES, V43, P113
   DALLMAN MF, 1998, HDB PHYSL ENV
   DEKLOET ER, 1991, FRONT NEUROENDOCRIN, V12, P95
   DODT C, 1993, NEUROENDOCRINOLOGY, V58, P570, DOI 10.1159/000126592
   GAILLARD RC, 1984, P NATL ACAD SCI-BIOL, V81, P3879, DOI 10.1073/pnas.81.12.3879
   GOLD PW, 1986, NEW ENGL J MED, V314, P1335, DOI 10.1056/NEJM198605223142102
   KROWZOWSKI ZS, 1983, P NATL ACAD SCI USA, V80, P6056
   LINKOWSKI P, 1985, J CLIN ENDOCR METAB, V61, P429, DOI 10.1210/jcem-61-3-429
   LINKOWSKI P, 1987, J CLIN ENDOCR METAB, V65, P141, DOI 10.1210/jcem-65-1-141
   MAYOSMITH W, 1989, RADIOLOGY, V170, P515, DOI 10.1148/radiology.170.2.2911678
   OKA M, 1956, ACTA MED SCAND, V154, P221
   OLSSON T, 1989, STROKE, V20, P1695
   PIRKE KM, 1993, NEUROSCI BIOBEHAV R, V17, P287, DOI 10.1016/S0149-7634(05)80012-0
   RATKA A, 1989, NEUROENDOCRINOLOGY, V50, P117, DOI 10.1159/000125210
   REBUFFESCRIVE M, 1992, PHYSIOL BEHAV, V52, P583, DOI 10.1016/0031-9384(92)90351-2
   REUL JMHM, 1985, ENDOCRINOLOGY, V117, P2505, DOI 10.1210/endo-117-6-2505
   RODGERS BD, 1995, DIABETES, V44, P1420, DOI 10.2337/diabetes.44.12.1420
   Rosmond R, 1998, J CLIN ENDOCR METAB, V83, P1853, DOI 10.1210/jc.83.6.1853
   SALATA RA, 1988, J CLIN INVEST, V81, P766, DOI 10.1172/JCI113382
   Samuels MH, 1997, J CLIN ENDOCR METAB, V82, P3700, DOI 10.1210/jc.82.11.3700
   Samuels MH, 1996, J CLIN ENDOCR METAB, V81, P32, DOI 10.1210/jc.81.1.32
   SCHWARTZ MW, 1992, ENDOCR REV, V13, P387, DOI 10.1210/er.13.3.387
   Schwartz MW, 1997, REGUL PEPTIDES, V72, P105, DOI 10.1016/S0167-0115(97)01043-4
   SCRIBNER KA, 1993, ENDOCRINOLOGY, V133, P2667, DOI 10.1210/en.133.6.2667
   SPENCER RL, 1990, BRAIN RES, V514, P37, DOI 10.1016/0006-8993(90)90433-C
   Spencer RL, 1998, ENDOCRINOLOGY, V139, P2718, DOI 10.1210/en.139.6.2718
   SPENCER RL, 1993, ENDOCRINOLOGY, V133, P1941, DOI 10.1210/en.133.5.1941
   SPENCER RL, 1990, NEUROENDOCRINOLOGY, V52, P481, DOI 10.1159/000125632
   STRACK AM, 1995, AM J PHYSIOL-REG I, V268, pR183, DOI 10.1152/ajpregu.1995.268.1.R183
   STRACK AM, 1995, AM J PHYSIOL-REG I, V268, pR142, DOI 10.1152/ajpregu.1995.268.1.R142
   STRACK AM, 1995, AM J PHYSIOL-REG I, V268, pR1209, DOI 10.1152/ajpregu.1995.268.5.R1209
   VanCauter E, 1996, J CLIN ENDOCR METAB, V81, P2468, DOI 10.1210/jc.81.7.2468
   YOUNG EA, 1995, J NEUROENDOCRINOL, V7, P37, DOI 10.1111/j.1365-2826.1995.tb00665.x
NR 44
TC 89
Z9 102
U1 0
U2 7
PU NATURE PUBLISHING GROUP
PI BASINGSTOKE
PA HOUNDMILLS, BASINGSTOKE RG21 6XS, HAMPSHIRE, ENGLAND
SN 0307-0565
J9 INT J OBESITY
JI Int. J. Obes.
PD JUN
PY 2000
VL 24
SU 2
BP S40
EP S46
DI 10.1038/sj.ijo.0801276
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 335NW
UT WOS:000088250400010
PM 10997607
DA 2025-06-11
ER

PT J
AU Sánchez-Villegas, A
   Delgado-Rodríguez, M
   Alonso, A
   Schlatter, J
   Lahortiga, F
   Majem, LS
   Martínez-González, MA
AF Sanchez-Villegas, Almudena
   Delgado-Rodriguez, Miguel
   Alonso, Alvaro
   Schlatter, Javier
   Lahortiga, Francisca
   Serra Majem, Lluis
   Angel Martinez-Gonzalez, Miguel
TI Association of the Mediterranean Dietary Pattern With the Incidence of
   Depression The Seguimiento Universidad de Navarra/University
   of Navarra Follow-up (SUN) Cohort
SO ARCHIVES OF GENERAL PSYCHIATRY
LA English
DT Article
ID POLYUNSATURATED FATTY-ACIDS; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   ENDOTHELIAL FUNCTION; HOMOCYSTEINE LEVELS; PHYSICAL-ACTIVITY; MAJOR
   DEPRESSION; MENTAL-DISORDERS; RISK-FACTORS; STYLE DIET
AB Context: Adherence to the Mediterranean dietary pattern (MDP) is thought to reduce inflammatory, vascular, and metabolic processes that may be involved in the risk of clinical depression.
   Objective: To assess the association between adherence to the MDP and the incidence of clinical depression.
   Design: Prospective study that uses a validated 136-item food frequency questionnaire to assess adherence to the MDP. The MDP score positively weighted the consumption of vegetables, fruit and nuts, cereal, legumes, and fish; the monounsaturated- to saturated-fatty-acids ratio; and moderate alcohol consumption, whereas meat or meat products and whole-fat dairy were negatively weighted.
   Setting: A dynamic cohort of university graduates (Seguimiento Universidad de Navarra/University of Navarra Follow-up [SUN] Project).
   Participants: A total of 10094 initially healthy Spanish participants from the SUN Project participated in the study. Recruitment began on December 21, 1999, and is ongoing.
   Main Outcome Measure: Participants were classified as having incident depression if they were free of depression and antidepressant medication at baseline and reported a physician-made diagnosis of clinical depression and/or antidepressant medication use during follow-up.
   Results: After a median follow-up of 4.4 years, 480 new cases of depression were identified. The multiple adjusted hazard ratios (95% confidence intervals) of depression for the 4 upper successive categories of adherence to the MDP(taking the category of lowest adherence as reference) were 0.74 (0.57-0.98), 0.66 (0.50-0.86), 0.49 (0.36-0.67), and 0.58 (0.44-0.77) (P for trend <.001). Inverse dose-response relationships were found for fruit and nuts, the monounsaturated- to saturated-fatty-acids ratio, and legumes.
   Conclusions: Our results suggest a potential protective role of the MDP with regard to the prevention of depressive disorders; additional longitudinal studies and trials are needed to confirm these findings.
C1 [Angel Martinez-Gonzalez, Miguel] Univ Navarra, Dept Prevent Med & Publ Hlth, Univ Navarra Clin, E-31080 Pamplona, Spain.
   [Sanchez-Villegas, Almudena; Serra Majem, Lluis] Univ Las Palmas Gran Canaria, Dept Clin Sci, Las Palmas Gran Canaria, Spain.
   [Delgado-Rodriguez, Miguel] Univ Jaen, Div Prevent Med & Publ Hlth, Jaen, Spain.
   [Schlatter, Javier; Lahortiga, Francisca] Univ Navarra, Dept Psychiat & Med Psychol, E-31080 Pamplona, Spain.
   [Alonso, Alvaro] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.
C3 University of Navarra; Universidad de Las Palmas de Gran Canaria;
   Universidad de Jaen; University of Navarra; University of Minnesota
   System; University of Minnesota Twin Cities
RP Martínez-González, MA (corresponding author), Univ Navarra, Dept Prevent Med & Publ Hlth, Univ Navarra Clin, E-31080 Pamplona, Spain.
RI Sanchez-Villegas, Almudena/T-6733-2019; Martinez-Gonzalez,
   Miguel/AAE-7669-2019; ALONSO GOMEZ, ANGEL/HLG-2476-2023; Rodríguez,
   Miguel/KCZ-1828-2024; Serra-Majem, Lluis/I-6708-2019; Lahortiga-Ramos,
   Francisca/H-9363-2017; Alonso, Alvaro/A-4917-2010; Delgado Rodriguez,
   Miguel/H-4940-2017
OI Sanchez Villegas, Almudena/0000-0001-7733-9238; Lahortiga-Ramos,
   Francisca/0000-0001-7624-6902; Martinez-Gonzalez, Miguel
   A./0000-0002-3917-9808; Alonso, Alvaro/0000-0002-2225-8323; Serra-Majem,
   Lluis/0000-0002-9658-9061; Delgado Rodriguez, Miguel/0000-0002-3838-2548
FU Spanish Government Instituto de Salud Carlos III; Fondo de
   Investigaciones Sanitarias [PI042241, PI040233, PI050976, PI070240,
   PI0801943, RD 06/0045]; Navarra Regional Government project [PI41/2005]
FX The Spanish Government Instituto de Salud Carlos III, Fondo de
   Investigaciones Sanitarias, projects PI042241, PI040233, PI050976,
   PI070240, PI0801943, and RD 06/0045 and the Navarra Regional Government
   project PI41/2005 supported the study.
CR Akbaraly TN, 2009, DIABETES CARE, V32, P499, DOI 10.2337/dc08-1358
   Appleton KM, 2006, AM J CLIN NUTR, V84, P1308, DOI 10.1093/ajcn/84.6.1308
   Assies J, 2004, PROSTAG LEUKOTR ESS, V70, P349, DOI 10.1016/j.plefa.2003.12.009
   Astorg P, 2008, BRIT J NUTR, V100, P183, DOI 10.1017/S0007114507873612
   Belmaker RH, 2008, NEW ENGL J MED, V358, P55, DOI [10.1056/NEJMra073096, 10.1038/nrdp.2016.65]
   Bottiglieri T, 1996, NUTR REV, V54, P382, DOI 10.1111/j.1753-4887.1996.tb03851.x
   Bremmer MA, 2008, J AFFECT DISORDERS, V106, P249, DOI 10.1016/j.jad.2007.07.002
   Byrd-Bredbenner C, 2000, J HUM NUTR DIET, V13, P197, DOI [10.1046/j.1365-277x.2000.00232.x, 10.1046/j.1365-277X.2000.00232.x]
   Chishti P, 2003, EUR J PUBLIC HEALTH, V13, P108, DOI 10.1093/eurpub/13.2.108
   Chrysohoou C, 2004, J AM COLL CARDIOL, V44, P152, DOI 10.1016/j.jacc.2004.03.039
   COLANGELO LA, 2009, NUTRITION
   Dai J, 2008, CIRCULATION, V117, P169, DOI 10.1161/CIRCULATIONAHA.107.710699
   Dimopoulos N, 2007, J GERIATR PSYCH NEUR, V20, P138, DOI 10.1177/0891988707301867
   Dowrick Christopher, 2002, World Psychiatry, V1, P169
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   Estruch R, 2006, ANN INTERN MED, V145, P1, DOI 10.7326/0003-4819-145-1-200607040-00004
   Fernstrom JD, 1999, LIPIDS, V34, P161, DOI 10.1007/s11745-999-0350-3
   Ford DE, 2004, ARCH INTERN MED, V164, P1010, DOI 10.1001/archinte.164.9.1010
   Fuentes F, 2008, BRIT J NUTR, V100, P159, DOI 10.1017/S0007114508888708
   Gimeno D, 2009, PSYCHOL MED, V39, P413, DOI 10.1017/S0033291708003723
   Goldbacher EM, 2009, PSYCHOSOM MED, V71, P266, DOI 10.1097/PSY.0b013e318197a4d5
   Greenland S., 2008, Modern Epidemiology, V3rd, P359
   Grenyer BFS, 2007, PROG NEURO-PSYCHOPH, V31, P1393, DOI 10.1016/j.pnpbp.2007.06.004
   Guo SZ, 2008, P NATL ACAD SCI USA, V105, P7582, DOI 10.1073/pnas.0801105105
   Gussinyer S, 2008, MED CLIN-BARCELONA, V131, P245, DOI 10.1016/S0025-7753(08)72243-7
   Irmisch G, 2007, PROSTAG LEUKOTR ESS, V76, P1, DOI 10.1016/j.plefa.2006.09.001
   Kamphuis MH, 2008, EUR J CLIN NUTR, V62, P939, DOI 10.1038/sj.ejcn.1602804
   Karatzi K, 2008, J AM COLL NUTR, V27, P448, DOI 10.1080/07315724.2008.10719724
   Karege F, 2005, MOL BRAIN RES, V136, P29, DOI 10.1016/j.molbrainres.2004.12.020
   Korn EL, 1997, AM J EPIDEMIOL, V145, P72
   Kovess-Masfety V, 2007, PSYCHIAT SERV, V58, P213, DOI 10.1176/appi.ps.58.2.213
   Kyrozis A, 2009, J PSYCHIATR RES, V43, P763, DOI 10.1016/j.jpsychires.2008.09.003
   Logan AC, 2005, PROSTAG LEUKOTR ESS, V72, P441, DOI 10.1016/j.plefa.2005.02.006
   Lopez AD, 2006, LANCET, V367, P1747, DOI 10.1016/S0140-6736(06)68770-9
   Löwe B, 2004, J AFFECT DISORDERS, V78, P131, DOI 10.1016/S0165-0327(02)00237-9
   Martínez-González MA, 2005, PUBLIC HEALTH NUTR, V8, P920, DOI 10.1079/PHN2005745
   Martínez-González MA, 2002, NUTR NEUROSCI, V5, P65, DOI 10.1080/10284150290007047
   MARTINMORENO JM, 1993, INT J EPIDEMIOL, V22, P512, DOI 10.1093/ije/22.3.512
   Mena MP, 2009, AM J CLIN NUTR, V89, P248, DOI 10.3945/ajcn.2008.26094
   Mufioz MA, 2009, BR J NUTR, V101, P1
   Murakami K, 2008, NUTRITION, V24, P140, DOI 10.1016/j.nut.2007.10.013
   Núñez-Córdoba JM, 2009, AM J EPIDEMIOL, V169, P339, DOI 10.1093/aje/kwn335
   Paile-Hyvärinen M, 2007, ANN MED, V39, P634, DOI 10.1080/07853890701545722
   Panagiotakos DB, 2004, EUR HEART J, V25, P492, DOI 10.1016/j.ehj.2004.01.018
   Panagiotakos DB, 2007, J AM COLL NUTR, V26, P32, DOI 10.1080/07315724.2007.10719583
   Paniagua JA, 2007, DIABETES CARE, V30, P1717, DOI 10.2337/dc06-2220
   Rogers PJ, 2008, BRIT J NUTR, V99, P421, DOI 10.1017/S0007114507801097
   Salas-Salvadó J, 2008, ARCH INTERN MED, V168, P2449, DOI 10.1001/archinte.168.22.2449
   Sánchez-Villegas A, 2006, PUBLIC HEALTH NUTR, V9, P1104, DOI 10.1017/S1368980007668578
   Sánchez-Villegas A, 2009, J HUM NUTR DIET, V22, P122, DOI 10.1111/j.1365-277X.2008.00931.x
   Sanchez-Villegas A, 2008, MED SCI SPORT EXER, V40, P827, DOI 10.1249/MSS.0b013e31816348b9
   Sanchez-Villegas A, 2007, EUR J NUTR, V46, P337, DOI 10.1007/s00394-007-0671-x
   Sanchez-Villegas A, 2008, BMC PSYCHIATRY, V8, DOI 10.1186/1471-244X-8-43
   Sarris J, 2009, NUTR REV, V67, P125, DOI 10.1111/j.1753-4887.2009.00180.x
   Silvers KM, 2005, PROSTAG LEUKOTR ESS, V72, P211, DOI 10.1016/j.plefa.2004.11.004
   Simon GE, 2008, GEN HOSP PSYCHIAT, V30, P32, DOI 10.1016/j.genhosppsych.2007.09.001
   Sontrop J, 2006, PREV MED, V42, P4, DOI 10.1016/j.ypmed.2005.11.005
   Tolmunen T, 2004, PSYCHOTHER PSYCHOSOM, V73, P334, DOI 10.1159/000080385
   Tortosa A, 2007, DIABETES CARE, V30, P2957, DOI 10.2337/dc07-1231
   Trichopoulou A, 2003, NEW ENGL J MED, V348, P2599, DOI 10.1056/NEJMoa025039
   Vaccarino V, 2007, J AM COLL CARDIOL, V50, P2044, DOI 10.1016/j.jacc.2007.07.069
   Wagner JA, 2006, PSYCHOSOM MED, V68, P80, DOI 10.1097/01.psy.0000195868.68122.9e
   WELLS KB, 1991, AM J PSYCHIAT, V148, P1688
   Willett W. C., 1998, Nutritional Epidemiology, V2nd ed., P321, DOI DOI 10.1093/AJCN/69.5.1020
NR 64
TC 434
Z9 472
U1 3
U2 72
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0003-990X
EI 1538-3636
J9 ARCH GEN PSYCHIAT
JI Arch. Gen. Psychiatry
PD OCT
PY 2009
VL 66
IS 10
BP 1090
EP 1098
DI 10.1001/archgenpsychiatry.2009.129
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 502YE
UT WOS:000270496100006
PM 19805699
DA 2025-06-11
ER

PT J
AU Alla, V
   Bonkovsky, HL
AF Alla, V
   Bonkovsky, HL
TI Iron in nonhemochromatotic liver disorders
SO SEMINARS IN LIVER DISEASE
LA English
DT Review
DE alcohol; cirrhosis; hepatitis C; iron; nonalcoholic fatty liver disease;
   nonalcoholic steatohepatitis; porphyria cutanea tarda
ID CHRONIC HEPATITIS-C; PORPHYRIA-CUTANEA-TARDA; NONALCOHOLIC FATTY LIVER;
   INTERFERON-ALPHA THERAPY; CHRONIC VIRAL-HEPATITIS; ERYTHROCYTE
   UROPORPHYRINOGEN DECARBOXYLASE; INSULIN-RESISTANCE SYNDROME; LONG-TERM
   RESPONSE; HFE GENE-MUTATIONS; HEMOCHROMATOSIS GENE
AB Iron is essential for cellular functions, but in excessive amounts it is toxic to cells. The harmful effects are related to increased oxidative stress and production of reactive oxygen species causing oxidative damage to lipids, proteins, and nucleic acids. Heavy iron overload as occurs in primary and secondary hemochromatosis can cause fibrosis of various parenchymal organs such as the liver, heart, and pancreas. Lesser degrees of hepatic iron deposition are also associated with, and seem to be risk factors for, certain nonhemochromatotic liver diseases. Porphyria cutanea tarda is associated with hepatic iron overload and responds to iron-reduction therapy. Other recent evidence indicates that the prevalence of HFE gene mutations is increased in chronic viral hepatitis and that patients with chronic hepatitis C harboring especially the C282Y mutation are more likely to suffer from advanced hepatic fibrosis or cirrhosis and to do so at younger ages. In this article we review selected nonhemochromatotic disorders in which iron can play an important comorbid role.
C1 Univ Connecticut, Ctr Hlth, Dept Med, Farmington, CT 06030 USA.
   Univ Connecticut, Ctr Hlth, Dept Mol, Farmington, CT 06030 USA.
   Univ Connecticut, Ctr Hlth, Dept Microbial, Farmington, CT 06030 USA.
   Univ Connecticut, Ctr Hlth, Dept Biol Struct, Farmington, CT 06030 USA.
   Univ Connecticut, Ctr Hlth, Liver Biliary Pancreat Ctr, Farmington, CT 06030 USA.
C3 University of Connecticut; University of Connecticut; University of
   Connecticut; University of Connecticut; University of Connecticut
RP Univ Connecticut, Ctr Hlth, Dept Med, MC 1111,263 Farmington Ave, Farmington, CT 06030 USA.
EM bonkovsky@uchc.edu
RI Bonkovsky, Herbert/AAH-1892-2021
FU NIDDK NIH HHS [UO1 DK065193, N01 DK92326, R01 DK38825] Funding Source:
   Medline
CR Adams PC, 1996, HEPATOLOGY, V23, P724, DOI 10.1053/jhep.1996.v23.pm0008666324
   Alter MJ, 1999, J HEPATOL, V31, P88, DOI 10.1016/S0168-8278(99)80381-X
   Angulo P, 1999, HEPATOLOGY, V30, P1356, DOI 10.1002/hep.510300604
   Aoki CA, 2005, J CLIN GASTROENTEROL, V39, P71
   ARBER N, 1994, DIGEST DIS SCI, V39, P2656, DOI 10.1007/BF02087705
   BACON BR, 1994, GASTROENTEROLOGY, V107, P1103, DOI 10.1016/0016-5085(94)90235-6
   BARTON AL, 1995, AM J CLIN PATHOL, V103, P419
   BEGUIN Y, 1988, AM J HEMATOL, V29, P204, DOI 10.1002/ajh.2830290406
   BLUMBERG BS, 1981, P NATL ACAD SCI-BIOL, V78, P3222, DOI 10.1073/pnas.78.5.3222
   Bonkovsky H L, 1999, Curr Gastroenterol Rep, V1, P30, DOI 10.1007/s11894-999-0084-5
   Bonkovsky H L, 2000, Clin Liver Dis, V4, P409, DOI 10.1016/S1089-3261(05)70116-1
   Bonkovsky HL, 1999, J HEPATOL, V31, P421, DOI 10.1016/S0168-8278(99)80032-4
   Bonkovsky HL, 2003, ALCOHOL, V30, P137, DOI 10.1016/S0741-8329(03)00127-7
   Bonkovsky HL, 2002, J HEPATOL, V37, P848, DOI 10.1016/S0168-8278(02)00305-7
   Bonkovsky HL, 1996, SEMIN LIVER DIS, V16, P65, DOI 10.1055/s-2007-1007220
   Bonkovsky HL, 2002, AM J GASTROENTEROL, V97, P1
   Bonkovsky HL, 1998, HEPATOLOGY, V27, P1661, DOI 10.1002/hep.510270627
   Bonkovsky HL, 1997, HEPATOLOGY, V25, P759, DOI 10.1002/hep.510250345
   Boucher E, 1997, GUT, V41, P115, DOI 10.1136/gut.41.1.115
   Bulaj ZJ, 2000, BLOOD, V95, P1565, DOI 10.1182/blood.V95.5.1565.005k42_1565_1571
   CHAPMAN RW, 1983, DIGEST DIS SCI, V28, P321, DOI 10.1007/BF01324948
   Chitturi S, 2002, HEPATOLOGY, V35, P373, DOI 10.1053/jhep.2002.30692
   Clark JM, 2002, GASTROENTEROLOGY, V122, P1649, DOI 10.1053/gast.2002.33573
   Clark JM, 2003, AM J GASTROENTEROL, V98, P960, DOI [10.1016/S0002-9270(03)00265-X, 10.1111/j.1572-0241.2003.07486.x]
   Cömert B, 2001, DIGEST LIVER DIS, V33, P353, DOI 10.1016/S1590-8658(01)80091-8
   Cortez-Pinto H, 1999, CLIN NUTR, V18, P353, DOI 10.1016/S0261-5614(99)80015-6
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   De Feo TM, 2001, ALCOHOL CLIN EXP RES, V25, P1494, DOI 10.1097/00000374-200110000-00013
   de Sousa Maria, 1998, Journal of Hepatology, V28, P1, DOI 10.1016/S0168-8278(98)80367-X
   Desai TK, 1998, GASTROENTEROLOGY, V114, pA1233
   Dètivaud L, 2005, BLOOD, V106, P746, DOI 10.1182/blood-2004-12-4855
   Di Bisceglie AM, 2000, HEPATOLOGY, V32, P135, DOI 10.1053/jhep.2000.8700
   DIBISCEGLIE AM, 1992, GASTROENTEROLOGY, V102, P2108, DOI 10.1016/0016-5085(92)90339-Z
   DUANE P, 1992, ALCOHOL ALCOHOLISM, V27, P539
   Egger NG, 2002, DIGEST DIS SCI, V47, P419, DOI 10.1023/A:1013746828074
   ELDER GH, 1985, LANCET, V2, P229
   ELDER GH, 1980, CLIN SCI, V58, P477, DOI 10.1042/cs0580477
   Facchini FS, 2002, GASTROENTEROLOGY, V122, P931, DOI 10.1053/gast.2002.32403
   FARGION S, 1992, HEPATOLOGY, V15, P655, DOI 10.1002/hep.1840150417
   FARGION S, 1994, HEPATOLOGY, V20, P1426, DOI 10.1002/hep.1840200608
   Fargion S, 1997, EUR J GASTROEN HEPAT, V9, P497, DOI 10.1097/00042737-199705000-00016
   Fargion S, 2002, AM J GASTROENTEROL, V97, P1204
   Fernández-Real JM, 2005, CLIN CHEM, V51, P1201, DOI 10.1373/clinchem.2004.046847
   Fletcher LM, 2003, ALCOHOL, V30, P131, DOI 10.1016/S0741-8329(03)00128-9
   Fong TL, 1998, J HEPATOL, V28, P369, DOI 10.1016/S0168-8278(98)80308-5
   Fontana RJ, 2000, HEPATOLOGY, V31, P730, DOI 10.1002/hep.510310325
   Frenzer A, 1998, SCAND J GASTROENTERO, V33, P1324
   Fried MW, 2002, NEW ENGL J MED, V347, P975, DOI 10.1056/NEJMoa020047
   George DK, 1998, GASTROENTEROLOGY, V114, P311, DOI 10.1016/S0016-5085(98)70482-2
   Gorman N, 2002, HEPATOLOGY, V35, P912, DOI 10.1053/jhep.2002.32487
   Grove J, 1998, GUT, V43, P262, DOI 10.1136/gut.43.2.262
   HARRISONFINDIK D, 2005, BIO IRON 2005, P24
   HAYASHI H, 1994, AM J GASTROENTEROL, V89, P986
   Ikura Y, 1996, AM J GASTROENTEROL, V91, P1367
   Ioannou GN, 2004, GASTROENTEROLOGY, V126, P1293, DOI 10.1053/j.gastro.2004.01.020
   JAKOBOVITS AW, 1979, DIGEST DIS SCI, V24, P305, DOI 10.1007/BF01296545
   Kazemi-Shirazi L, 1999, GASTROENTEROLOGY, V116, P127, DOI 10.1016/S0016-5085(99)70236-2
   Kimura F, 2005, HEPATO-GASTROENTEROL, V52, P563
   Knobler H, 1999, QJM-MON J ASSOC PHYS, V92, P73, DOI 10.1093/qjmed/92.2.73
   Knutson MD, 2005, P NATL ACAD SCI USA, V102, P1324, DOI 10.1073/pnas.0409409102
   KOSZO F, 1992, BRIT J DERMATOL, V126, P446, DOI 10.1111/j.1365-2133.1992.tb15114.x
   Lambrecht Richard W, 2002, Semin Gastrointest Dis, V13, P109
   Lavanchy D, 1999, J VIRAL HEPATITIS, V6, P35
   Loguercio C, 2004, DIGEST LIVER DIS, V36, P398, DOI 10.1016/j.dld.2004.01.022
   Loguercio C, 2001, J HEPATOL, V35, P568, DOI 10.1016/S0168-8278(01)00192-1
   LOREAL O, 1992, J HEPATOL, V16, P122, DOI 10.1016/S0168-8278(05)80104-7
   LUDWIG J, 1980, MAYO CLIN PROC, V55, P434
   LUNDVALL O, 1969, ACTA MED SCAND, V185, P259
   LUSTBADER ED, 1983, SCIENCE, V220, P423, DOI 10.1126/science.6301008
   MacDONALD RICHARD A., 1966, PROGR HEMATOLIN PROGRESS IN HEMATOLOGY, V5, P324
   Manns MP, 2001, LANCET, V358, P958, DOI 10.1016/S0140-6736(01)06102-5
   Marchesini G, 1999, AM J MED, V107, P450, DOI 10.1016/S0002-9343(99)00271-5
   Marchesini G, 2001, DIABETES, V50, P1844, DOI 10.2337/diabetes.50.8.1844
   Martinelli ALC, 1999, ACTA HAEMATOL-BASEL, V102, P152, DOI 10.1159/000040991
   MAZZANTI R, 1987, ALCOHOL ALCOHOLISM, V22, P47
   MILMAN N, 1994, HEPATO-GASTROENTEROL, V41, P20
   Nemeth E, 2004, SCIENCE, V306, P2090, DOI 10.1126/science.1104742
   Nitecki J, 2000, GASTROENTEROLOGY, V118, pA1474, DOI 10.1016/S0016-5085(00)81800-4
   OHTAKE T, 2005, BIO IRON 2005, P73
   OLYNYK JK, 1995, GASTROENTEROLOGY, V108, P1104, DOI 10.1016/0016-5085(95)90209-0
   Pagano G, 2002, HEPATOLOGY, V35, P367, DOI 10.1053/jhep.2002.30690
   Park CH, 2001, J BIOL CHEM, V276, P7806, DOI 10.1074/jbc.M008922200
   Pascoe A, 2000, HEPATOLOGY, V32, P159, DOI 10.1053/jhep.2000.8704
   Pascoe A, 1999, GUT, V45, P301, DOI 10.1136/gut.45.2.301
   Pietrangelo A, 2004, NEW ENGL J MED, V350, P2383, DOI 10.1056/NEJMra031573
   Pietrangelo A, 2003, GASTROENTEROLOGY, V124, P1509, DOI 10.1016/S0016-5085(03)00275-0
   Piperno A, 1998, HEPATOLOGY, V28, P1105, DOI 10.1002/hep.510280427
   Piperno A, 1996, LIVER, V16, P248
   POWELL LW, 1966, AUSTRALAS ANN MED, V15, P110
   Raynard B, 2002, HEPATOLOGY, V35, P635, DOI 10.1053/jhep.2002.31782
   REGOECZI E, 1984, ALCOHOL CLIN EXP RES, V8, P287, DOI 10.1111/j.1530-0277.1984.tb05513.x
   Roberts AG, 1997, LANCET, V349, P321, DOI 10.1016/S0140-6736(96)09436-6
   Roetto A, 2003, NAT GENET, V33, P21, DOI 10.1038/ng1053
   ROUACH H, 1994, BIOCHEM PHARMACOL, V47, P1835, DOI 10.1016/0006-2952(94)90313-1
   SABESIN SM, 1964, GASTROENTEROLOGY, V46, P477
   Sampietro M, 1998, HEPATOLOGY, V27, P181, DOI 10.1002/hep.510270128
   Sanyal AJ, 2001, GASTROENTEROLOGY, V120, P1183, DOI 10.1053/gast.2001.23256
   Sartori M, 1998, ITAL J GASTROENTEROL, V30, P396
   Sartori M, 2000, J GASTROEN HEPATOL, V15, P1411, DOI 10.1046/j.1440-1746.2000.02368.x
   Seeff L B, 1997, Clin Liver Dis, V1, P587, DOI 10.1016/S1089-3261(05)70323-8
   Shan Y, 2005, CLIN INFECT DIS, V40, P834, DOI 10.1086/428062
   Sinclair PR, 2003, HEPATOLOGY, V37, P351, DOI 10.1053/jhep.2003.50034
   Sinclair PR, 1998, BIOCHEM J, V330, P149
   Sinclair PR, 2000, TOXICOL APPL PHARM, V162, P60, DOI 10.1006/taap.1999.8832
   Smith AG, 2001, TOXICOL APPL PHARM, V173, P89, DOI 10.1006/taap.2001.9167
   Smith BC, 1998, HEPATOLOGY, V27, P1695, DOI 10.1002/hep.510270631
   Stuart KA, 1998, J HEPATOL, V28, P404, DOI 10.1016/S0168-8278(98)80313-9
   Suzuki Y, 2002, ALCOHOL CLIN EXP RES, V26, p26S, DOI 10.1097/01.ALC.0000026830.27338.23
   Tankurt E, 1999, J HEPATOL, V31, P963, DOI 10.1016/S0168-8278(99)80301-8
   Tannapfel A, 2001, VIRCHOWS ARCH, V439, P1, DOI 10.1007/s004280100401
   Thursz M, 1997, GASTROENTEROLOGY, V112, pA1401
   TONG MJ, 1995, NEW ENGL J MED, V332, P1463, DOI 10.1056/NEJM199506013322202
   Tsai NCS, 1997, AM J GASTROENTEROL, V92, P1831
   TSUKAMOTO H, 1995, J CLIN INVEST, V96, P620, DOI 10.1172/JCI118077
   Tung BY, 2003, GASTROENTEROLOGY, V124, P318, DOI 10.1053/gast.2003.50046
   Valenti L, 2003, GASTROENTEROLOGY, V124, P866, DOI 10.1053/gast.2003.50130
   VANTHIEL DH, 1994, J HEPATOL, V20, P410, DOI 10.1016/S0168-8278(94)80017-0
   Willner IR, 2001, AM J GASTROENTEROL, V96, P2957
   Yano M, 2002, AM J GASTROENTEROL, V97, P133, DOI 10.1111/j.1572-0241.2002.05436.x
   Younossi ZM, 1999, HEPATOLOGY, V30, P847, DOI 10.1002/hep.510300407
NR 120
TC 103
Z9 109
U1 0
U2 4
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0272-8087
EI 1098-8971
J9 SEMIN LIVER DIS
JI Semin. Liver Dis.
PY 2005
VL 25
IS 4
BP 461
EP 472
DI 10.1055/s-2005-923317
PG 12
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 990KY
UT WOS:000233743000009
PM 16315139
DA 2025-06-11
ER

PT J
AU Kim, J
   Jung, EJ
   Moon, SS
   Seo, M
AF Kim, Jongwan
   Jung, Eun Jung
   Moon, Seong-Su
   Seo, Minchul
TI Protective effect of carbenoxolone on ER stress-induced cell death in
   hypothalamic neurons
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Carbenoxolone (CBX); Endoplasmic reticulum stress; Hypothalamus;
   Apoptosis; Reactive oxygen species
ID ENDOPLASMIC-RETICULUM STRESS; 11-BETA-HYDROXYSTEROID DEHYDROGENASE
   TYPE-1; INSULIN SENSITIVITY; METABOLIC SYNDROME; FATTY LIVER;
   BODY-WEIGHT; FOOD-INTAKE; OBESITY; MICE; PATHOGENESIS
AB Hypothalamic endoplasmic reticulum (ER) stress is known to be increased in obesity. Induction of ER stress on hypothalamic neurons has been reported to cause hypothalamic neuronal apoptosis and malfunction of energy balance, leading to obesity. Carbenoxolone is an 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) inhibitor that converts inactive glucocorticoid into an active form. In addition to its metabolic effect via enzyme inhibitory action, carbenoxolone has shown anti-apoptotic activity in several studies. In this study, the direct effects of carbenoxolone on ER stress and cell death in hypothalamic neurons were investigated. Carbenoxolone attenuated tunicamycin induced ER stress-mediated molecules such as spliced XBP1, ATF4, ATF6, CHOP, and ROS generation. In vivo study also revealed that carbenoxolone decreased tunicamycin-induced ER stress in the hypothalamus. In conclusion, the results of this study show that carbenoxolone has protective effects against tunicamycin induced-ER stress and apoptosis in hypothalamic neurons, suggesting its direct protective effects against obesity. Further study is warranted to clarify the effects of carbenoxolone on hypothalamic regulation of energy balance in obesity. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Kim, Jongwan; Moon, Seong-Su; Seo, Minchul] Dongguk Univ, Coll Med, Inst Med Res, Gyeongju, South Korea.
   [Jung, Eun Jung] Dongguk Univ, Coll Med, Dept Biochem, Gyeongju, South Korea.
   [Moon, Seong-Su] Dongguk Univ, Coll Med, Dept Internal Med, Gyeongju, South Korea.
   [Kim, Jongwan] Dongguk Univ, Coll Med, Grad Sch, Dept Anat, Gyeongju, South Korea.
C3 Dongguk University; Dongguk University; Dongguk University; Dongguk
   University
RP Seo, M (corresponding author), Dongguk Univ, Coll Med, Dept Internal Med, Gyeongju, South Korea.
EM drmoonss@hanmail.net; nansmc@hanmail.net
FU Dongguk University [K-2014-G0002-00009]
FX This work was supported by the Dongguk University research fund of
   K-2014-G0002-00009.
CR Alberts P, 2002, DIABETOLOGIA, V45, P1528, DOI 10.1007/s00125-002-0959-6
   Andrews RC, 2003, J CLIN ENDOCR METAB, V88, P285, DOI 10.1210/jc.2002-021194
   Bassik MC, 2011, P NATL ACAD SCI USA, V108, P11731, DOI 10.1073/pnas.1109035108
   Bygrave FL, 1996, CELL CALCIUM, V19, P547, DOI 10.1016/S0143-4160(96)90064-0
   Denis RG, 2010, NEUROSCIENCE, V170, P1035, DOI 10.1016/j.neuroscience.2010.08.013
   Elmquist JK, 2005, J COMP NEUROL, V493, P63, DOI 10.1002/cne.20786
   Evans-Molina C, 2013, DIABETES OBES METAB, V15, P159, DOI 10.1111/dom.12163
   GROSSMAN SP, 1975, PSYCHOL REV, V82, P200, DOI 10.1037/0033-295X.82.3.200
   Gura T, 1997, SCIENCE, V275, P751, DOI 10.1126/science.275.5301.751
   Hannan MA, 2013, PHYTOTHER RES, V27, P21, DOI 10.1002/ptr.4684
   Hellmich HL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0053230
   James WPT, 2008, J INTERN MED, V263, P336, DOI 10.1111/j.1365-2796.2008.01922.x
   Kahn BB, 2005, CELL METAB, V1, P15, DOI 10.1016/j.cmet.2004.12.003
   Khorasani MZ, 2009, PAK J PHARM SCI, V22, P349
   Kopelman P, 2007, OBES REV, V8, P13, DOI 10.1111/j.1467-789X.2007.00311.x
   Liu Y, 2008, PHYSIOL GENOMICS, V32, P343, DOI 10.1152/physiolgenomics.00067.2007
   Masuzaki H, 2001, SCIENCE, V294, P2166, DOI 10.1126/science.1066285
   Matsuda M, 1999, DIABETES, V48, P1801, DOI 10.2337/diabetes.48.9.1801
   Milanski M, 2009, J NEUROSCI, V29, P359, DOI 10.1523/JNEUROSCI.2760-08.2009
   Morton GJ, 2006, NATURE, V443, P289, DOI 10.1038/nature05026
   Ozcan L, 2009, CELL METAB, V9, P35, DOI 10.1016/j.cmet.2008.12.004
   Paterson JM, 2004, P NATL ACAD SCI USA, V101, P7088, DOI 10.1073/pnas.0305524101
   Purkayastha S, 2011, P NATL ACAD SCI USA, V108, P2939, DOI 10.1073/pnas.1006875108
   Rhee SD, 2012, EUR J PHARMACOL, V691, P9, DOI 10.1016/j.ejphar.2012.06.021
   Sano R, 2013, BBA-MOL CELL RES, V1833, P3460, DOI 10.1016/j.bbamcr.2013.06.028
   Sonenberg N, 2009, CELL, V136, P731, DOI 10.1016/j.cell.2009.01.042
   Tabas I, 2010, CIRC RES, V107, P839, DOI 10.1161/CIRCRESAHA.110.224766
   Taylor A, 2008, BIOL CHEM, V389, P441, DOI 10.1515/BC.2008.049
   Won JC, 2009, OBESITY, V17, P1861, DOI 10.1038/oby.2009.194
   YAMASHITA N, 1992, BRAIN RES, V594, P215, DOI 10.1016/0006-8993(92)91128-2
   Zhang L, 2013, NEUROSCI BULL, V29, P311, DOI 10.1007/s12264-013-1342-y
   Zhang XQ, 2008, CELL, V135, P61, DOI 10.1016/j.cell.2008.07.043
   Zhang XQ, 2014, WORLD J GASTROENTERO, V20, P1768, DOI 10.3748/wjg.v20.i7.1768
NR 33
TC 10
Z9 10
U1 0
U2 6
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD DEC 25
PY 2015
VL 468
IS 4
BP 793
EP 799
DI 10.1016/j.bbrc.2015.11.034
PG 7
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA DA5UQ
UT WOS:000367868500044
PM 26577412
DA 2025-06-11
ER

PT J
AU Pike, IL
AF Pike, IL
TI The nutritional consequences of pregnancy sickness - A critique of a
   hypothesis
SO HUMAN NATURE-AN INTERDISCIPLINARY BIOSOCIAL PERSPECTIVE
LA English
DT Article
DE East Africa; evolutionary medicine; maternal nutrition; pastoralists;
   pregnancy outcome
ID LOW-BIRTH-WEIGHT; CORTICOTROPIN-RELEASING HORMONE; INSULIN-RESISTANCE
   SYNDROME; CHORIONIC-GONADOTROPIN; REPRODUCTIVE HISTORY; MATERNAL WEIGHT;
   NOMADIC TURKANA; FUNDAL HEIGHT; AFRICAN WOMEN; BACON CHOW
AB The purpose of this paper is to assess Profet's (1992) and others' hypothesis that nausea and vomiting in pregnancy (NVP) is adaptive. A number of studies have found an association between NVP and a decreased risk for early fetal loss (<20 weeks). It is assumed that the adaptive benefits of improved survivorship associated with NVP outweigh the minimal nutritional consequences. However, in populations that experience marginal levels of nutrition, NVP may have important nutritional consequences. To test these potential consequences, a study on NVP, nutritional status, and pregnancy outcome was conducted among Turkana pastoralists, who experience seasonal and chronic nutritional stress. Interviews and anthropometric assessments were conducted on 68 pregnant Turkana women of Kenya during a 1993-1994 field season. The results from the case study suggest that women who experience NVP do encounter nutritional consequences in the later stages of pregnancy and are more likely to experience poor pregnancy outcomes. These results suggest that NVP may not be adaptive in all environmental settings, particularly among marginally nourished populations.
C1 Ohio State Univ, Dept Anthropol, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University
RP Ohio State Univ, Dept Anthropol, 115 Lord Hall,124 W 17th Ave, Columbus, OH 43210 USA.
EM pike.21@osu.edu
CR ADAIR LS, 1984, BRIT J NUTR, V51, P357, DOI 10.1079/BJN19840042
   ADAIR LS, 1985, AM J CLIN NUTR, V41, P948, DOI 10.1093/ajcn/41.5.948
   ADAIR LS, 1983, AM J PHYS ANTHROPOL, V62, P325, DOI 10.1002/ajpa.1330620312
   ADAIR LS, 1987, NUTRITIONAL ANTHR, P119
   ALLEN LH, 1994, EUR J CLIN NUTR, V48, pS68
   Anderson M., 1991, Maternal Nutrition and Pregnancy Outcome: Anthropometric Assessment, P1
   ANDERSSON R, 1995, J TROP MED HYG, V98, P169
   [Anonymous], 1997, Int J Gynaecol Obstet, V57, P1
   [Anonymous], GESTATIONAL AGE NEWB
   BARKER DJP, 1993, LANCET, V341, P938, DOI 10.1016/0140-6736(93)91224-A
   BEHRMAN CA, 1990, J ADOLESCENT HEALTH, V11, P418, DOI 10.1016/0197-0070(90)90089-K
   BRANDES JM, 1967, OBSTET GYNECOL, V30, P427
   CHRISTOFIDES ND, 1982, BMJ-BRIT MED J, V285, P1453, DOI 10.1136/bmj.285.6353.1453
   Denver RJ, 1997, HORM BEHAV, V31, P169, DOI 10.1006/hbeh.1997.1383
   Dodic M, 1999, TRENDS ENDOCRIN MET, V10, P86, DOI 10.1016/S1043-2760(98)00125-8
   DUBOWITZ LM, 1970, J PEDIATR-US, V77, P1, DOI 10.1016/S0022-3476(70)80038-5
   FAIRWEATHER DVI, 1965, AM J OBST GYNECOLOGY, V102, P135
   FITZGERALD CM, 1984, BRIT J MED PSYCHOL, V57, P159, DOI 10.1111/j.2044-8341.1984.tb01595.x
   FOLEY RA, 1993, HUMAN ECOLOGY SEASON, P17
   FRISCH RE, 1987, HUM REPROD, V2, P521, DOI 10.1093/oxfordjournals.humrep.a136582
   GADSBY R, 1993, BRIT J GEN PRACT, V43, P245
   Galvin K. A., 1994, African pastoralist systems: an integrated approach., P113
   Galvin KA, 1999, RES MG HUM, P125
   GALVIN KA, 1992, AM J HUM BIOL, V4, P209, DOI 10.1002/ajhb.1310040206
   Galvin KA., 1985, THESIS SUNY BINGHAMT
   Gonzalez-Cossio T, 1991, World Rev Nutr Diet, V64, P139
   GRABOWSKI CT, 1983, HUMAN REPROD DEV
   Hook E. B., 1976, BIRTH DEFECTS RISKS
   *I MED, 1990, NUTR PREGNANCY
   INDIRA R, 1990, INT J GYNECOL OBSTET, V33, P1, DOI 10.1016/0020-7292(90)90646-3
   JARNFELTSAMSIOE A, 1986, EUR J OBSTET GYN R B, V21, P87, DOI 10.1016/0028-2243(86)90047-X
   JARNFELTSAMSIOE A, 1985, GYNECOL OBSTET INVES, V19, P174
   JARNFELTSAMSIOE A, 1986, ACTA OBSTET GYN SCAN, V65, P745
   JARNFELTSAMSIOE A, 1983, GYNECOL OBSTET INVES, V16, P221
   JELLIFFE DB, 1964, CLIN PEDIATR, V3, P432, DOI 10.1177/000992286400300710
   KLEBANOFF MA, 1985, OBSTET GYNECOL, V66, P612
   KRAMER MS, 1987, B WORLD HEALTH ORGAN, V65, P663
   KRASOVEC K, 1991, PAN AM H O, V529, P59
   LAWOYIN TO, 1991, J TROP PEDIATRICS, V37, P166, DOI 10.1093/tropej/37.4.166
   LESLIE PW, 1984, HUM ECOL, V12, P137, DOI 10.1007/BF01531270
   LESLIE PW, 1996, HUM BIOL, V65, P237
   LESLIE PW, 1990, S URKANA ECOSYSTEM P
   LITTLE MA, 1989, YEARB PHYS ANTHROPOL, V32, P215
   LITTLE MA, 1983, HUM BIOL, V55, P811
   Little MA, 1999, RES MG HUM, P187
   LITTLE MA, 1992, AM J HUM BIOL, V4, P729, DOI 10.1002/ajhb.1310040604
   LITTLE RE, 1980, ACTA OBSTET GYN SCAN, V59, P495, DOI 10.3109/00016348009155438
   Lohman TG., 1988, Anthropometric standardization reference manual
   MASSON GM, 1985, BRIT J OBSTET GYNAEC, V92, P211, DOI 10.1111/j.1471-0528.1985.tb01084.x
   MCCORMICK MC, 1985, NEW ENGL J MED, V312, P82, DOI 10.1056/NEJM198501103120204
   McLean M, 1999, TRENDS ENDOCRIN MET, V10, P174, DOI 10.1016/S1043-2760(98)00146-5
   MCLEAN M, 1995, NAT MED, V1, P460, DOI 10.1038/nm0595-460
   MEDALIE JH, 1957, LANCET, V2, P117
   MILKOVICH L, 1976, AM J OBSTET GYNECOL, V125, P244, DOI 10.1016/0002-9378(76)90601-3
   Minturn L, 1984, Med Anthropol, V8, P71
   O'Connor KA, 1999, AM J PHYS ANTHROPOL, V108, P377, DOI 10.1002/(SICI)1096-8644(199903)108:3<377::AID-AJPA12>3.0.CO;2-7
   OCONNOR K, 1998, AM J PHYS ANTHROPOL, V105, P172
   PEBLEY AR, 1985, POPULATION STUDIES, V39, P440
   PETITTI DB, 1986, BIRTH-ISS PERINAT C, V13, P223, DOI 10.1111/j.1523-536X.1986.tb01052.x
   Phillips DIW, 1998, J CLIN ENDOCR METAB, V83, P757, DOI 10.1210/jc.83.3.757
   Phillips DIW, 1997, DIABETIC MED, V14, P673, DOI 10.1002/(SICI)1096-9136(199708)14:8<673::AID-DIA458>3.0.CO;2-9
   Pike IL, 1999, AM J HUM BIOL, V11, P658
   PIKE IL, IN PRESS AM J PHYSIC
   PRENTICE AM, 1987, AM J CLIN NUTR, V46, P912, DOI 10.1093/ajcn/46.6.912
   PROFET M, 1988, Evolutionary Theory, V8, P177
   Profet M., 1992, The adapted mind, P327
   SCHOLL TO, 1995, SEMIN PERINATOL, V19, P171, DOI 10.1016/S0146-0005(05)80023-0
   SCHOLL TO, 1990, OBSTET GYNECOL, V75, P948
   SIEGARIZ AM, 1993, AM J CLIN NUTR, V57, P365, DOI 10.1093/ajcn/57.3.365
   SiegaRiz AM, 1996, J NUTR, V126, P146, DOI 10.1093/jn/126.1.146
   Sokal RR., 1995, Biometry, P887
   SOULES MR, 1980, OBSTET GYNECOL, V55, P696
   TIERSON FD, 1986, AM J OBSTET GYNECOL, V155, P1017, DOI 10.1016/0002-9378(86)90337-6
   VELLACOTT ID, 1988, INT J GYNECOL OBSTET, V27, P57, DOI 10.1016/0020-7292(88)90088-4
   VILLAR J, 1986, EARLY HUM DEV, V14, P307, DOI 10.1016/0378-3782(86)90193-3
   WALKER ARP, 1985, BRIT J OBSTET GYNAEC, V92, P484, DOI 10.1111/j.1471-0528.1985.tb01353.x
   WEIGEL MM, 1989, BRIT J OBSTET GYNAEC, V96, P1304, DOI 10.1111/j.1471-0528.1989.tb03228.x
   WEIGEL MM, 1988, AM J EPIDEMIOL, V127, P562, DOI 10.1093/oxfordjournals.aje.a114831
   WEIGEL RM, 1989, BRIT J OBSTET GYNAEC, V96, P1312, DOI 10.1111/j.1471-0528.1989.tb03229.x
   Wood J.W., 1994, DYNAMICS HUMAN REPRO
   YERUSHALMY J, 1965, AM J OBSTET GYNECOL, V93, P553, DOI 10.1016/0002-9378(65)90515-6
NR 81
TC 15
Z9 18
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1045-6767
EI 1936-4776
J9 HUM NATURE-INT BIOS
JI Hum. Nat.-Interdiscip. Biosoc. Perspect.
PY 2000
VL 11
IS 3
BP 207
EP 232
DI 10.1007/s12110-000-1011-5
PG 26
WC Anthropology; Social Sciences, Biomedical
WE Social Science Citation Index (SSCI)
SC Anthropology; Biomedical Social Sciences
GA 360AY
UT WOS:000089645300001
PM 26193475
DA 2025-06-11
ER

PT J
AU Henley, DE
   Lightman, SL
AF Henley, D. E.
   Lightman, S. L.
TI NEW INSIGHTS INTO CORTICOSTEROID-BINDING GLOBULIN AND GLUCOCORTICOID
   DELIVERY
SO NEUROSCIENCE
LA English
DT Article
DE corticosteroid-binding globulin; CBG; transcortin; cortisol;
   glucocorticoid; hypothalamic-pituitary-adrenal axis
ID STEROID-PROTEIN INTERACTIONS; INSULIN-RESISTANCE SYNDROME;
   PITUITARY-ADRENAL AXIS; CELL-MEMBRANES; CEREBROSPINAL-FLUID; SALIVARY
   CORTISOL; HORMONE RECEPTORS; STRESS RESPONSES; RAT; EXPRESSION
AB Corticosteroid-binding globulin (CBG) binds cortisol with high affinity and facilitates its transport in the blood. A recent discovery suggests that CBG may have a role beyond that of a simple transport carrier protein. CBG functions as a protein thermocouple that is exquisitely sensitive to temperature change, releasing cortisol in response to increasing temperatures within the human physiological range. It is also expressed in the human hypothalamus and cerebrospinal fluid, while in the rodent it is also found in other intracellular neuronal locations, suggesting a role in regulating access of glucocorticoids to their receptors in the CNS. Genetic variants of CBG have been detected in man and have been associated with fatigue-pain syndromes and hypotension, again suggesting a potential effect of CBG on the access of cortisol to brain glucocorticoid receptors. These new findings provide the basis for a novel concept of the mechanisms through which the body regulates access of glucocorticoids to the brain and other tissues of the body. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
C1 [Lightman, S. L.] Univ Bristol, Henry Wellcome Labs Integrat Neurosci & Endocrino, Bristol BS1 3NY, Avon, England.
   [Henley, D. E.] Univ Western Australia, Fac Med Dent & Hlth Sci, Crawley, WA 6009, Australia.
   [Henley, D. E.] Sir Charles Gairdner Hosp, Dept Endocrinol & Diabet, Nedlands, WA 6009, Australia.
C3 University of Bristol; University of Western Australia; University of
   Western Australia; Sir Charles Gairdner Hospital
RP Lightman, SL (corresponding author), Univ Bristol, Henry Wellcome Labs Integrat Neurosci & Endocrino, Whitson St, Bristol BS1 3NY, Avon, England.
EM Stafford.Lightman@bristol.ac.uk
RI Lightman, Stafford/G-2107-2011
CR Ballard P L, 1979, Monogr Endocrinol, V12, P25
   Beauchamp NJ, 1998, BLOOD, V92, P2696, DOI 10.1182/blood.V92.8.2696.420a43_2696_2706
   BRIGHT GM, 1995, J CLIN ENDOCR METAB, V80, P764, DOI 10.1210/jc.80.3.764
   BRIGHT GM, 1995, J CLIN ENDOCR METAB, V80, P770, DOI 10.1210/jc.80.3.770
   Cameron A, 2010, J CLIN ENDOCR METAB, V95, P4689, DOI 10.1210/jc.2010-0942
   CARROLL RS, 1995, NEUROSURGERY, V37, P496, DOI 10.1227/00006123-199509000-00019
   Chrousos GP, 2007, STRESS, V10, P213, DOI 10.1080/10253890701292119
   DEKLOET ER, 1984, J STEROID BIOCHEM, V20, P367, DOI 10.1016/0022-4731(84)90235-8
   DEMOOR P, 1962, J CLIN INVEST, V41, P816
   Dhillo WS, 2002, EUR J ENDOCRINOL, V146, P231, DOI 10.1530/eje.0.1460231
   Droste SK, 2009, J NEUROENDOCRINOL, V21, P132, DOI 10.1111/j.1365-2826.2008.01811.x
   Droste SK, 2008, ENDOCRINOLOGY, V149, P3244, DOI 10.1210/en.2008-0103
   Droste SK, 2009, ENDOCRINOLOGY, V150, P4170, DOI 10.1210/en.2009-0402
   Emptoz-Bonneton A, 2000, J CLIN ENDOCR METAB, V85, P361, DOI 10.1210/jc.85.1.361
   Fernandez-Real JM, 2005, METABOLISM, V54, P584, DOI 10.1016/j.metabol.2004.11.015
   Fernández-Real JM, 2000, CLIN ENDOCRINOL, V52, P93
   Fernandez-Real JM, 2002, J CLIN ENDOCR METAB, V87, P4686, DOI 10.1210/jc.2001-011843
   Fernández-Real JM, 2001, METABOLISM, V50, P1248, DOI 10.1053/meta.2001.25647
   Fernández-Real JM, 1999, J CLIN ENDOCR METAB, V84, P3192, DOI 10.1210/jc.84.9.3192
   FLESHNER M, 1995, ENDOCRINOLOGY, V136, P5336, DOI 10.1210/en.136.12.5336
   Gagliardi L, 2010, MOL CELL ENDOCRINOL, V316, P24, DOI 10.1016/j.mce.2009.07.015
   Galbois A, 2010, J HEPATOL, V52, P839, DOI 10.1016/j.jhep.2010.01.026
   HAMMOND GL, 1990, J CLIN ENDOCR METAB, V71, P34, DOI 10.1210/jcem-71-1-34
   HAMMOND GL, 1987, P NATL ACAD SCI USA, V84, P5153, DOI 10.1073/pnas.84.15.5153
   HAMMOND GL, 1991, J STEROID BIOCHEM, V40, P755, DOI 10.1016/0960-0760(91)90300-T
   HAMMOND GL, 1990, ENDOCR REV, V11, P65, DOI 10.1210/edrv-11-1-65
   Henley DE, 2009, J CLIN ENDOCR METAB, V94, P4234, DOI 10.1210/jc.2009-1174
   Ho JT, 2006, J CLIN ENDOCR METAB, V91, P105, DOI 10.1210/jc.2005-0265
   HRYB DJ, 1986, P NATL ACAD SCI USA, V83, P3253, DOI 10.1073/pnas.83.10.3253
   HSU BRS, 1988, ENDOCRINOLOGY, V122, P421, DOI 10.1210/endo-122-2-421
   Jirikowski GF, 2007, J CHEM NEUROANAT, V34, P22, DOI 10.1016/j.jchemneu.2007.03.007
   Juruena MF, 2010, PSYCHONEUROENDOCRINO, V35, P1486, DOI 10.1016/j.psyneuen.2010.04.016
   KHAN MS, 1984, J STEROID BIOCHEM, V20, P677, DOI 10.1016/0022-4731(84)90142-0
   Klieber MA, 2007, J BIOL CHEM, V282, P29594, DOI 10.1074/jbc.M705014200
   Kumsta R, 2007, PSYCHONEUROENDOCRINO, V32, P1153, DOI 10.1016/j.psyneuen.2007.08.007
   Lacroix A, 2010, J CLIN ENDOCR METAB, V95, P4812, DOI 10.1210/jc.2010-0990
   Lewis JG, 2006, HORM METAB RES, V38, P241, DOI 10.1055/s-2006-925338
   Lewis JG, 2005, CLIN CHIM ACTA, V359, P189, DOI 10.1016/j.cccn.2005.03.044
   Lightman SL, 2008, J NEUROENDOCRINOL, V20, P880, DOI 10.1111/j.1365-2826.2008.01711.x
   Lightman S L, 2000, Novartis Found Symp, V227, P244
   Lightman SL, 2008, EUR J PHARMACOL, V583, P255, DOI 10.1016/j.ejphar.2007.11.073
   Lin HY, 2010, MOL CELL ENDOCRINOL, V316, P3, DOI 10.1016/j.mce.2009.06.015
   Lowry CA, 2009, J PSYCHOPHARMACOL, V23, P392, DOI 10.1177/0269881108099956
   MAITRA US, 1993, ENDOCRINOLOGY, V133, P1817, DOI 10.1210/en.133.4.1817
   Manchikanti Laxmaiah, 2002, Pain Physician, V5, P182
   MENDEL CM, 1989, ENDOCR REV, V10, P232, DOI 10.1210/edrv-10-3-232
   MICKELSON KE, 1982, BIOCHEMISTRY-US, V21, P654, DOI 10.1021/bi00533a010
   MICKELSON KE, 1981, BIOCHEMISTRY-US, V20, P6211, DOI 10.1021/bi00524a047
   Moisan MP, 2010, MOL CELL ENDOCRINOL, V316, P35, DOI 10.1016/j.mce.2009.07.017
   Möpert B, 2006, HORM METAB RES, V38, P246, DOI 10.1055/S-2006-925344
   MUSA BU, 1967, J CLIN ENDOCR METAB, V27, P1463, DOI 10.1210/jcem-27-10-1463
   NAKHLA AM, 1988, BIOCHEM BIOPH RES CO, V153, P1012, DOI 10.1016/S0006-291X(88)81329-9
   NEUFELD JH, 1994, PHARMACOL BIOCHEM BE, V47, P233, DOI 10.1016/0091-3057(94)90005-1
   ORAVA M, 1994, GENE, V144, P259, DOI 10.1016/0378-1119(94)90387-5
   Ousova O, 2004, MOL ENDOCRINOL, V18, P1687, DOI 10.1210/me.2004-0005
   PAOLETTI P, 1990, J NEUROSURG, V73, P736, DOI 10.3171/jns.1990.73.5.0736
   Perogamvros I, 2010, J CLIN ENDOCR METAB, V95, pE142, DOI 10.1210/jc.2010-0746
   Petersen HH, 2006, MOL CELL BIOL, V26, P7236, DOI 10.1128/MCB.00400-06
   PREDINE J, 1984, J CLIN ENDOCR METAB, V58, P6, DOI 10.1210/jcem-58-1-6
   Pusch L, 2009, CELL MOL NEUROBIOL, V29, P583, DOI 10.1007/s10571-009-9350-1
   Qureshi AC, 2007, CLIN ENDOCRINOL, V66, P632, DOI 10.1111/j.1365-2265.2007.02784.x
   Raff H, 2008, ENDOCRINE, V34, P68, DOI 10.1007/s12020-008-9101-y
   Revest JM, 2005, NAT NEUROSCI, V8, P664, DOI 10.1038/nn1441
   Richard E, 2009, INT J GENET MOL BIOL, V1, P59
   Richard EM, 2010, ENDOCRINOLOGY, V151, P649, DOI 10.1210/en.2009-0862
   ROSNER W, 1990, ENDOCR REV, V11, P80, DOI 10.1210/edrv-11-1-80
   ROSNER W, 1988, ANN NY ACAD SCI, V538, P137
   SCHWARZ S, 1992, NEUROENDOCRINOLOGY, V55, P174, DOI 10.1159/000126112
   SCROCCHI LA, 1993, ENDOCRINOLOGY, V132, P910, DOI 10.1210/en.132.2.910
   SCROCCHI LA, 1993, ENDOCRINOLOGY, V132, P903, DOI 10.1210/en.132.2.903
   Shanks N, 2000, P NATL ACAD SCI USA, V97, P5645, DOI 10.1073/pnas.090571897
   SIITERI PK, 1982, RECENT PROG HORM RES, V38, P457
   SINGER CJ, 1988, ENDOCRINOLOGY, V122, P89, DOI 10.1210/endo-122-1-89
   Sivukhina EV, 2006, HORM METAB RES, V38, P253, DOI 10.1055/s-2006-925346
   SMITH CL, 1991, J BIOL CHEM, V266, P18555
   Spencer RL, 1996, PSYCHONEUROENDOCRINO, V21, P95, DOI 10.1016/0306-4530(95)00020-8
   Stavreva DA, 2009, NAT CELL BIOL, V11, P1093, DOI 10.1038/ncb1922
   STEWART PM, 2008, WILLIAMS TXB ENDOCRI, P454
   STRELCHYONOK OA, 1991, J STEROID BIOCHEM, V40, P795, DOI 10.1016/0960-0760(91)90305-O
   Torpy DJ, 2007, CLIN ENDOCRINOL, V67, P161, DOI 10.1111/j.1365-2265.2007.02890.x
   Torpy DJ, 2001, J CLIN ENDOCR METAB, V86, P3692, DOI 10.1210/jc.86.8.3692
   VAN BH, 1982, J BIOL CHEM, V257, P3397
   VANSETERS AP, 1991, ACTA ENDOCRINOL-COP, V124, P526, DOI 10.1530/acta.0.1240526
   Walker JJ, 2010, P ROY SOC B-BIOL SCI, V277, P1627, DOI 10.1098/rspb.2009.2148
   Westphal U, 1986, Monogr Endocrinol, V27, P1
   Willnow TE, 2010, MOL CELL ENDOCRINOL, V316, P93, DOI 10.1016/j.mce.2009.07.021
   Windle RJ, 2001, J NEUROENDOCRINOL, V13, P905, DOI 10.1046/j.1365-2826.2001.00715.x
   Zhou AW, 2008, J MOL BIOL, V380, P244, DOI 10.1016/j.jmb.2008.05.012
NR 88
TC 84
Z9 96
U1 0
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
EI 1873-7544
J9 NEUROSCIENCE
JI Neuroscience
PD APR 28
PY 2011
VL 180
BP 1
EP 8
DI 10.1016/j.neuroscience.2011.02.053
PG 8
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 748MV
UT WOS:000289395600001
PM 21371536
DA 2025-06-11
ER

PT J
AU El Asmar, K
   Annan, NB
   Khoury, R
   Colle, R
   Martin, S
   Ghoul, TE
   Trabado, S
   Chanson, P
   Feve, B
   Verstuyft, C
   Becquemont, L
   Corruble, E
AF El Asmar, K.
   Annan, N. B.
   Khoury, R.
   Colle, R.
   Martin, S.
   Ghoul, T. E.
   Trabado, S.
   Chanson, P.
   Feve, B.
   Verstuyft, C.
   Becquemont, L.
   Corruble, E.
TI Non-overweight depressed patients who respond to antidepressant
   treatment have a higher risk of later metabolic syndrome: findings from
   the METADAP cohort
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Antidepressant; depression; MetS; response to treatment; weight
ID WEIGHT-GAIN; PREDICTORS; METAANALYSIS; ASSOCIATION
AB Background. Major depressive disorder (MDD) is a complex disorder with a significant public health burden. Depression remission is often associated with weight gain, a major risk factor for metabolic syndrome (MetS). The primary objective of our study was to assess prospectively the impact of response to antidepressant treatment on developing MetS in a sample of MDD patients with a current major depressive episode (MDE) and who are newly initiating their treatment.
   Methods. In the 6-month prospective METADAP cohort, non-overweight patients, body mass index <25 kg/m(2), with MDD and a current MDE were assessed for treatment response after 3 months of treatment, and incidence of MetS after 3 and 6 months of treatment. Outcome variables were MetS, number of MetS criteria, and each MetS criterion (high waist circumference, high blood pressure, high triglyceridemia, low high-density lipoprotein-cholesterolemia, and high fasting plasma glucose).
   Results. In total, 98/169 patients (58%) responded to treatment after 3 months. A total of 2.7% (1/38) developed MetS out of which 12.7% (10/79) (p value < 0.001) had responded to treatment after 3 months. The fixed-effect regression models showed that those who responded to treatment after 3 months of follow-up had an 8.6 times higher odds of developing MetS (odds ratio = 8.58, 95% confidence interval 3.89-18.93, p value < 0.001).
   Conclusion. Compared to non-responders, non-overweight patients who responded to treatment after 3 months of antidepressant treatment had a significantly higher risk of developing MetS during the 6 months of treatment. Psychiatrists and nurses should closely monitor the metabolic profile of their patients, especially those who respond to treatment.
C1 [El Asmar, K.; Colle, R.; Martin, S.; Verstuyft, C.; Becquemont, L.; Corruble, E.] Univ Paris Saclay, Fac Med, CESP, MOODS Team,INSERM,UMR 1018, F-94275 Le Kremlin Bicetre, France.
   [El Asmar, K.; Annan, N. B.; Khoury, R.; Ghoul, T. E.] Amer Univ Beirut, Dept Epidemiol & Populat Hlth, Fac Hlth Sci, Beirut, Lebanon.
   [Colle, R.; Martin, S.; Corruble, E.] Hop Univ Paris Saclay, Hop Bicetre, AP HP, Serv Hosp Univ Psychiat Bicetre, F-94275 Le Kremlin Bicetre, France.
   [Trabado, S.; Chanson, P.] Univ Paris Saclay, Fac Med, INSERM, UMR S U1185, F-94275 Le Kremlin Bicetre, France.
   [Trabado, S.; Verstuyft, C.] Hop Univ Paris Saclay, Hop Bicetre, AP HP, Serv Genet Mol Pharmacogenet & Hormonol Bicetre, F-94275 Le Kremlin Bicetre, France.
   [Chanson, P.] Hop Bicetre, AP HP, Ctr Reference Malad Rares Hypophyse, Serv Endocrinol & Malad Reprod, F-94275 Le Kremlin Bicetre, France.
   [Feve, B.] Sorbonne Univ, Hop St Antoine, AP HP,INSERM, Ctr Rech St Antoine,Inst Hosp Univ ICAN,Serv Endo, F-75012 Paris, France.
   [Becquemont, L.] Hop Univ Paris Saclay, Hop Bicetre, AP HP, Ctr Rech Clin, F-94275 Le Kremlin Bicetre, France.
C3 Universite Paris Saclay; Institut National de la Sante et de la
   Recherche Medicale (Inserm); American University of Beirut; Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Bicetre - APHP;
   Universite Paris Saclay; Hopital Universitaire Antoine-Beclere - APHP;
   Universite Paris Saclay; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Paris Saclay; Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Antoine-Beclere -
   APHP; Hopital Universitaire Bicetre - APHP; Assistance Publique Hopitaux
   Paris (APHP); Hopital Universitaire Bicetre - APHP; Hopital
   Universitaire Antoine-Beclere - APHP; Universite Paris Saclay;
   Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital
   Universitaire Saint-Antoine - APHP; Institut National de la Sante et de
   la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris
   (APHP); Hopital Universitaire Bicetre - APHP; Hopital Universitaire
   Antoine-Beclere - APHP; Universite Paris Saclay
RP El Asmar, K (corresponding author), Univ Paris Saclay, Fac Med, CESP, MOODS Team,INSERM,UMR 1018, F-94275 Le Kremlin Bicetre, France.; El Asmar, K (corresponding author), Amer Univ Beirut, Dept Epidemiol & Populat Hlth, Fac Hlth Sci, Beirut, Lebanon.
EM ke05@aub.edu.lb
RI Chanson, Philippe/F-8511-2013; becquemont, laurent/KLD-8162-2024; Colle,
   Romain/IQV-1876-2023; verstuyft, celine/AAU-3343-2021; El Asmar,
   Khalil/A-3530-2019
OI Annan, Beyhan/0009-0006-4557-8203; El Ghoul, Tala/0000-0003-2315-6318;
   El-Khoury, Rayane/0000-0002-8709-6222; El Asmar,
   Khalil/0000-0002-6030-8088
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Anderson RJ, 2010, DIABETES CARE, V33, P485, DOI 10.2337/dc09-1466
   Bajbouj M, 2010, J CLIN PSYCHOPHARM, V30, P273, DOI 10.1097/JCP.0b013e3181db8831
   Bauer M, 2008, EUR PSYCHIAT, V23, P66, DOI 10.1016/j.eurpsy.2007.11.001
   Benazzi F, 1998, PSYCHOTHER PSYCHOSOM, V67, P271, DOI 10.1159/000012291
   Cattaneo A, 2013, NEUROPSYCHOPHARMACOL, V38, P377, DOI 10.1038/npp.2012.191
   Chockalingam R, 2019, HANDB EXP PHARMACOL, V250, P37, DOI 10.1007/164_2018_133
   Corruble E, 2015, WORLD PSYCHIATRY, V14, P366, DOI 10.1002/wps.20260
   Dale RM, 2020, J CLIN PSYCHOPHARM, V40, P75, DOI 10.1097/JCP.0000000000001149
   Delacrétaza A, 2017, PHARMACOGENET GENOM, V27, P464, DOI 10.1097/FPC.0000000000000313
   El Asmar K, 2018, J PSYCHIATR RES, V107, P120, DOI 10.1016/j.jpsychires.2018.10.021
   El Asmar K, 2018, J AFFECT DISORDERS, V241, P22, DOI 10.1016/j.jad.2018.07.059
   Fava M, 2000, J CLIN PSYCHIAT, V61, P37
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   He M, 2013, CNS DRUGS, V27, P423, DOI 10.1007/s40263-013-0062-1
   Honig Guillermo J, 2018, Vertex, V29, P139
   Licht CMM, 2009, HYPERTENSION, V53, P631, DOI 10.1161/HYPERTENSIONAHA.108.126698
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Pulkki-Råback L, 2009, HEALTH PSYCHOL, V28, P108, DOI 10.1037/a0012646
   Rush AJ, 2006, NEUROPSYCHOPHARMACOL, V31, P1841, DOI 10.1038/sj.npp.1301131
   Rush AJ, 2003, BIOL PSYCHIAT, V54, P573, DOI 10.1016/S0006-3223(02)01866-8
   RUSS MJ, 1988, APPETITE, V10, P103, DOI 10.1016/0195-6663(88)90062-1
   Sagud M, 2013, PSYCHOPHARMACOLOGY, V230, P15, DOI 10.1007/s00213-013-3085-x
   Salvi V, 2016, EUR NEUROPSYCHOPHARM, V26, P1673, DOI 10.1016/j.euroneuro.2016.08.012
   Salvi V, 2016, PSYCHOPHARMACOLOGY, V233, P49, DOI 10.1007/s00213-015-4085-9
   Sekita A, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-862
   Sirey JA, 2020, AM J GERIAT PSYCHIAT, V28, P1164, DOI 10.1016/j.jagp.2020.04.014
   Strawbridge Rebecca, 2018, Focus (Am Psychiatr Publ), V16, P194, DOI 10.1176/appi.focus.16206
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vigo D, 2016, LANCET PSYCHIAT, V3, P171, DOI 10.1016/S2215-0366(15)00505-2
   Vos T, 2013, LANCET, V381, P628
   Warden D, 2009, J PSYCHIATR PRACT, V15, P113, DOI 10.1097/01.pra.0000348364.88676.83
   Warden D, 2009, INT J NEUROPSYCHOPH, V12, P459, DOI 10.1017/S1461145708009073
   Yamaoka K, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-138
NR 34
TC 2
Z9 2
U1 2
U2 6
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD OCT
PY 2023
VL 53
IS 14
BP 6560
EP 6569
DI 10.1017/S0033291722003919
EA JAN 2023
PG 10
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA W1NW2
UT WOS:000910100300001
PM 36628576
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Schiavon, CC
   Marchetti, E
   Ayala, FO
   Loewe, G
   Bauer, J
   Busnello, FM
   Reppold, CT
AF Schiavon, Cecilia Cesa
   Marchetti, Eduarda
   Ayala, Fernanda Oliveira
   Loewe, Gabriela
   Bauer, Julia
   Busnello, Fernanda Michielin
   Reppold, Caroline Tozzi
TI Positive psychological characteristics in patients with metabolic
   syndrome associated with prospective changes in diet and anthropometric
   factors
SO PLOS ONE
LA English
DT Article
ID HEALTHY EATING INDEX; FOOD-CONSUMPTION; SELF-ESTEEM; WEIGHT-LOSS;
   VALIDATION; OPTIMISM; HOPE; VERSION; METAANALYSIS; QUALITY
AB The prevalence of metabolic syndrome (MetS) is increasing worldwide, and diet therapy plays a key role in treating this disease. Since most patients show difficulties in adhering to nutritional interventions, research on the association of positive psychological characteristics with greater engagement in physical health is relevant to this field. The present study aimed to evaluate the association between positive psychology attributes (optimism, hope, self-esteem, positive/negative affect and life satisfaction) and changes in diet quality and anthropometric parameters of individuals with MetS who received nutritional counseling. The study assessed 63 patients at a nutrition outpatient clinic. Anthropometric parameters and 24-hour food recall data (for evaluation of the Brazilian Healthy Eating Index-Revised-BHEI-R) were collected at the first visit and subsequent return visit (on average five months later). Psychological data were collected at the first visit using validated and standardized scales. The results were adjusted in relation to the depression scores of the patients, which were evaluated using the Beck Depression Inventory-II (BDI-II). Changes in anthropometric factors and in the BHEI-R were assessed, and their associations with the psychological attributes were investigated. The results indicated that positive affect and hope were associated with improvement in the BHEI-R scores (Cohen effect sizes -0.65 and -0.58; p = 0.012 and 0.025, respectively). A significant association was also observed between optimism and a reduction in abdominal circumference (Cohen effect size 0.56; p = 0.031). The associations remained significant even after adjusting for the BDI-II scores (p = 0.022, p = 0.037 and p = 0.05, respectively). No statistically significant associations were observed for the other attributes assessed.The study suggests that some attributes may have a greater influence on the nutritional treatment of MetS and that future studies should be conducted in order to enable effective multidisciplinary interventions to treat MetS.
C1 [Schiavon, Cecilia Cesa; Marchetti, Eduarda; Ayala, Fernanda Oliveira; Loewe, Gabriela; Bauer, Julia; Busnello, Fernanda Michielin; Reppold, Caroline Tozzi] Fed Univ Hlth Sci Porto Alegre UFCSPA, Dept Hlth Sci, Psychol Assessment Lab, Porto Alegre, RS, Brazil.
C3 Universidade Federal de Ciencias da Saude de Porto Alegre
RP Schiavon, CC (corresponding author), Fed Univ Hlth Sci Porto Alegre UFCSPA, Dept Hlth Sci, Psychol Assessment Lab, Porto Alegre, RS, Brazil.
EM cecilia.cesa@gmail.com
RI Busnello, Fernanda/AEX-2991-2022; Cesa, Cecilia/HQY-2615-2023
OI Michielin Busnello, Fernanda/0000-0001-9091-142X
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil
   (CAPES); Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
   (CNPq); Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior-Brasil (CAPES)
FX This study was financed in part by the Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior - Brasil (CAPES) and Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq). Authors who received
   this funding, characterized as a research grant were CCS, GL and CTR.
   The funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.The authors would
   like to thank professor Sinara Laurini Rossato, researcher at the
   Department of Nutrition of the Harvard School of Public Health, for
   providing training on the use of the NDSR software and Sheyla de Liz,
   researcher at the Federal University of Santa Catarina, for training in
   performing BHEI-R calculations. This study was financed in part by the
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brasil
   (CAPES) and Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq).
CR Alarcon GM, 2013, PERS INDIV DIFFER, V54, P821, DOI 10.1016/j.paid.2012.12.004
   Alfaro FJ, 2018, METABOLISM, V78, P52, DOI 10.1016/j.metabol.2017.08.009
   [Anonymous], 2005, Arquivos Brasileiros de Cardiologia, V84, P4, DOI 10.1590/s0066-782x2005000700001
   [Anonymous], 2006, IDF WORLDW DEF MET S
   [Anonymous], 2014, OBESITY SILVER SP S2, V22, pS40
   Bandura A., 2005, GREAT MINDS MANAGEME, P9
   Bastianello Micheline Roat, 2014, Psico-USF, V19, P523
   Boehm JK, 2012, PSYCHOL BULL, V138, P655, DOI 10.1037/a0027448
   Bonsaksen T, 2015, PSYCHOL HEALTH MED, V20, P431, DOI 10.1080/13548506.2014.959529
   Boylan JM, 2015, PSYCHOSOM MED, V77, P548, DOI 10.1097/PSY.0000000000000192
   Callegari-Jaques S., 2003, Bioestatistica: Principios e Aplicacoes
   Canetti L, 2009, INT J EAT DISORDER, V42, P109, DOI 10.1002/eat.20592
   Ceccatto V, 2014, NUTR HOSP, V30, P1101, DOI 10.3305/nh.2014.30.5.7439
   Clark L.A., 1994, The PANAS-X: Manual for the Positive and Negative Affect Schedule-Expanded Form
   Cohen J., 1988, STAT POWER ANAL BEHA, DOI [10.4324/9780203771587, DOI 10.4324/9780203771587]
   da Borralha SJP, 2011, THESIS
   de Carvalho CA, 2015, CIENC SAUDE COLETIVA, V20, P479, DOI 10.1590/1413-81232015202.02342014
   de Carvalho Vidigal Fernanda, 2013, BMC Public Health, V13, P1198, DOI 10.1186/1471-2458-13-1198
   Helena ETD, 2010, SAUDE SOC-SAO PAULO, V19, P614, DOI 10.1590/S0104-12902010000300013
   de Sousa AEC, 2014, HU REV, V40, P221
   Departamento de Vigilancia de Doencas e Agravos nAo Transmissiveis e PromocAo da Saude, 2017, VIG BRAS 2016 VIG FA
   Diener E, 2017, APPL PSYCHOL-HLTH WE, V9, P133, DOI 10.1111/aphw.12090
   Eid M, 2004, SOC INDIC RES, V65, P245, DOI 10.1023/B:SOCI.0000003801.89195.bc
   Faith MS, 2001, OBES RES, V9, P647, DOI 10.1038/oby.2001.86
   Fisberg RM, 2009, ARQ BRAS ENDOCRINOL, V53, P617, DOI 10.1590/S0004-27302009000500014
   Ford PA, 2013, J PSYCHOSOM RES, V74, P142, DOI 10.1016/j.jpsychores.2012.11.002
   Galinha Iolanda Costa, 2014, Psicologia, V28, P50
   Gana K, 2016, J PSYCHOSOM RES, V85, P28, DOI 10.1016/j.jpsychores.2016.04.004
   Gibson-Smith D, 2018, P NUTR SOC, V77, pE39, DOI 10.1017/S0029665118000332
   Gomes-Oliveira MH, 2012, REV BRAS PSIQUIATR, V34, P389, DOI 10.1016/j.rbp.2012.03.005
   Grant N, 2009, INT J BEHAV MED, V16, P259, DOI 10.1007/s12529-009-9032-x
   Huffman JC, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/428349
   Huffman JC, 2014, GEN HOSP PSYCHIAT, V36, P88, DOI 10.1016/j.genhosppsych.2013.10.006
   Hutz C S., 2014, Avaliacao em Psicologia Positiva
   Hutz CS, 2011, Avaliacao Psicologica, V10, P41
   Hutz CS, 2018, INTERVENCOES PSICOLO
   Kastorini CM, 2011, J AM COLL CARDIOL, V57, P1299, DOI 10.1016/j.jacc.2010.09.073
   Kelloniemi H, 2005, APPETITE, V45, P169, DOI 10.1016/j.appet.2005.05.001
   Kohlsdorf M., 2009, Psicologia Argumento, V27, P131
   Loureiro AD, 2013, REV NUTR, V26, P431, DOI 10.1590/S1415-52732013000400005
   Lundgren O, 2015, INT J BEHAV MED, V22, P77, DOI 10.1007/s12529-014-9387-5
   Martín-María N, 2017, PSYCHOSOM MED, V79, P565, DOI 10.1097/PSY.0000000000000444
   Meurer S.T., 2012, Motri., V8, P5
   Nothwehr F, 2013, J HUM NUTR DIET, V26, P159, DOI 10.1111/jhn.12057
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Pacico JC, 2013, INT J TEST, V13, P193, DOI 10.1080/15305058.2012.664833
   Post RE, 2012, J AM BOARD FAM MED, V25, P16, DOI 10.3122/jabfm.2012.01.110148
   Previdelli AN, 2011, REV SAUDE PUBL, V45, P794, DOI 10.1590/S0034-89102011005000035
   Reppold Caroline Tozzi, 2015, Psico-USF, V20, P275
   Robertson S, 2015, OBES RES CLIN PRACT, V9, P609, DOI 10.1016/j.orcp.2015.04.011
   Santos CE, 2009, ARQ BRAS ENDOCRINOL, V53, P1096, DOI 10.1590/S0004-27302009000900006
   Sbicigo Juliana Burges, 2010, Psico-USF, V15, P395
   SCHEIER MF, 1985, HEALTH PSYCHOL, V4, P219, DOI 10.1037/0278-6133.4.3.219
   SCHEIER MF, 1994, J PERS SOC PSYCHOL, V67, P1063, DOI 10.1037/0022-3514.67.6.1063
   Schiavon CC, 2017, FRONT PSYCHOL, V7, DOI 10.3389/fpsyg.2016.02022
   Scioli A, 2016, J POSIT PSYCHOL, V11, P135, DOI 10.1080/17439760.2015.1037858
   Seligman MEP, 2008, APPL PSYCHOL-INT REV, V57, P3, DOI 10.1111/j.1464-0597.2008.00351.x
   Seligman MEP, 2000, AM PSYCHOL, V55, P5, DOI 10.1037/0003-066X.55.1.5
   Silva KF, 2011, REV SOC BRAS MED TRO, V44, P425, DOI 10.1590/S0037-86822011000400005
   Snyder C.R., 2005, Handbook of Positive Psychology, P751
   SNYDER CR, 1991, J PERS SOC PSYCHOL, V60, P570, DOI 10.1037/0022-3514.60.4.570
   Snyder CR, 2002, PSYCHOL INQ, V13, P249, DOI 10.1207/S15327965PLI1304_01
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Somerset SM, 2011, CLIN NUTR, V30, P593, DOI 10.1016/j.clnu.2011.04.004
   Steptoe A, 2015, LANCET, V385, P640, DOI 10.1016/S0140-6736(13)61489-0
   Steptoe A, 2009, J PERS, V77, P1747, DOI 10.1111/j.1467-6494.2009.00599.x
   Stranges S, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2014-005878
   White BA, 2013, BRIT J HEALTH PSYCH, V18, P782, DOI 10.1111/bjhp.12021
   World Health Organization, 1995, WHO TECHN REP SER, V854, P1
   World Health Organization, 2014, NONC DIS COUNTR PROF
   Zanon C, 2014, SOC INDIC RES, V119, P443, DOI 10.1007/s11205-013-0478-5
   Zanon Cristian, 2013, Psico-USF, V18, P193
NR 72
TC 3
Z9 3
U1 0
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 1
PY 2020
VL 15
IS 9
AR e0236693
DI 10.1371/journal.pone.0236693
PG 19
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA NN6BT
UT WOS:000568872300015
PM 32870909
OA Green Published, gold
DA 2025-06-11
ER

PT S
AU Reckelhoff, JF
AF Reckelhoff, Jane F.
BE Kerkhof, PLM
   Miller, VM
TI Sex Differences in Regulation of Blood Pressure
SO SEX-SPECIFIC ANALYSIS OF CARDIOVASCULAR FUNCTION
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
DE Hypertension; Obesity; Metabolic syndrome; Postmenopausal women;
   Hypogonadism; Immune system-mediated hypertension; Androgens; Estrogens;
   Endothelin
ID SPONTANEOUSLY HYPERTENSIVE-RATS; RENIN-ANGIOTENSIN SYSTEM;
   SYMPATHETIC-NERVOUS-SYSTEM; POLYCYSTIC-OVARY-SYNDROME; OXIDATIVE STRESS;
   POSTMENOPAUSAL HYPERTENSION; ARACHIDONIC-ACID; REPLACEMENT THERAPY;
   GENDER-DIFFERENCES; ARTERIAL-PRESSURE
AB Hypertension is one of the leading risk factors for cardiovascular disease, myocardial infarction, and stroke. There are gender differences in the prevalence of hypertension and in the mechanisms responsible for hypertension in humans. This review will discuss the mechanisms for regulation of blood pressure, sex differences that have been identified in animal studies, and the gender differences that have been identified in humans.
C1 [Reckelhoff, Jane F.] Univ Mississippi, Med Ctr, Dept Cell & Mol Biol, Jackson, MS 39216 USA.
   [Reckelhoff, Jane F.] Univ Mississippi, Med Ctr, Womens Hlth Res Ctr, Jackson, MS 39216 USA.
   [Reckelhoff, Jane F.] Univ Mississippi, Med Ctr, Mississippi Ctr Excellence Perinatal Res, Jackson, MS 39216 USA.
C3 University of Mississippi; University of Mississippi Medical Center;
   University of Mississippi Medical Center; University of Mississippi;
   University of Mississippi Medical Center; University of Mississippi
RP Reckelhoff, JF (corresponding author), Univ Mississippi, Med Ctr, Dept Cell & Mol Biol, Jackson, MS 39216 USA.; Reckelhoff, JF (corresponding author), Univ Mississippi, Med Ctr, Womens Hlth Res Ctr, Jackson, MS 39216 USA.; Reckelhoff, JF (corresponding author), Univ Mississippi, Med Ctr, Mississippi Ctr Excellence Perinatal Res, Jackson, MS 39216 USA.
EM jreckelhoff@umc.edu
FU NHLBI NIH HHS [R01 HL069194, P01 HL051971, R01 HL066072] Funding Source:
   Medline; NIGMS NIH HHS [P20 GM121334] Funding Source: Medline; NIMH NIH
   HHS [K02 MH067028] Funding Source: Medline
CR Alexander BT, 2001, AM J PHYSIOL-REG I, V280, pR1388, DOI 10.1152/ajpregu.2001.280.5.R1388
   Azziz R, 2006, J CLIN ENDOCR METAB, V91, P4237, DOI 10.1210/jc.2006-0178
   Baba T, 2007, HUM REPROD, V22, P1011, DOI 10.1093/humrep/del474
   Ben-Dov IZ, 2007, HYPERTENSION, V49, P1235, DOI 10.1161/HYPERTENSIONAHA.107.087262
   Chappell MC, 2016, AM J PHYSIOL-HEART C, V310, pH137, DOI 10.1152/ajpheart.00618.2015
   Charikleia C, 2011, HORM-INT J ENDOCRINO, V10, P292, DOI 10.14310/horm.2002.1320
   Chobanian AV, 2003, JAMA-J AM MED ASSOC, V289
   da Silva AA, 2008, HYPERTENSION, V51, P884, DOI 10.1161/HYPERTENSIONAHA.107.100636
   Dalmasso C, 2016, AM J PHYSIOL-RENAL, V311, pF71, DOI 10.1152/ajprenal.00458.2015
   Davis DD, 2012, HYPERTENSION, V59, P726, DOI 10.1161/HYPERTENSIONAHA.111.180943
   de Kraker AT, 2009, EUR J OBSTET GYN R B, V142, P139, DOI 10.1016/j.ejogrb.2008.10.007
   Dhillion P, 2012, AM J PHYSIOL-REG I, V303, pR353, DOI 10.1152/ajpregu.00051.2012
   Diamanti-Kandarakis Evanthia, 2008, Expert Reviews in Molecular Medicine, V10, P1, DOI 10.1017/S1462399408000598
   do Carmo JM, 2017, BBA-MOL BASIS DIS, V1863, P2508, DOI 10.1016/j.bbadis.2017.03.003
   Escobar-Morreale HF, 2007, TRENDS ENDOCRIN MET, V18, P266, DOI 10.1016/j.tem.2007.07.003
   Ezzati M, 2002, LANCET, V360, P1347, DOI 10.1016/S0140-6736(02)11403-6
   Fortepiani LA, 2005, AM J PHYSIOL-REG I, V289, pR763, DOI 10.1152/ajpregu.00526.2004
   Fortepiani LA, 2005, J HYPERTENS, V23, P801, DOI 10.1097/01.hjh.0000163149.05083.13
   Fortepiani LA, 2005, AM J PHYSIOL-REG I, V288, pR733, DOI 10.1152/ajpregu.00500.2004
   Gohar EY, 2016, LIFE SCI, V159, P20, DOI 10.1016/j.lfs.2016.02.093
   Gu A, 2008, AM J HYPERTENS, V21, P78998
   Hall JE, 1996, KIDNEY INT, pS35
   Hall JE, 1995, HYPERTENSION PATHOPH, P1452
   Health United States. National Center for Health Statistics, 2010, NAT CTR HLTH STAT SP, P250
   Herrera J, 2006, J AM SOC NEPHROL, V17, pS218, DOI 10.1681/ASN.2006080918
   Hsia J, 2007, CIRCULATION, V115, P855, DOI 10.1161/CIRCULATIONAHA.106.656850
   Ichikawa A, 2008, GERIATR GERONTOL INT, V8, P259, DOI 10.1111/j.1447-0594.2008.00474.x
   Iliescu R, 2006, AM J PHYSIOL-REG I, V290, pR341, DOI 10.1152/ajpregu.00035.2005
   Issa Z, 2015, MENOPAUSE, V22, P456, DOI [10.1097/gme.0000000000000322, 10.1097/GME.0000000000000322]
   Kim JK, 2006, J WOMENS HEALTH, V15, P734, DOI 10.1089/jwh.2006.15.734
   Komatsumoto S, 1995, Nihon Ronen Igakkai Zasshi, V32, P664
   Lewington S, 2002, LANCET, V360, P1903, DOI 10.1016/S0140-6736(02)11911-8
   Lima R, 2013, AM J PHYSIOL-REG I, V304, pR248, DOI 10.1152/ajpregu.00380.2012
   Ljungman C, 2014, J AM SOC HYPERTENS, V8, P882, DOI 10.1016/j.jash.2014.08.015
   Lopez-Ruiz AF, 2010, AM J PHYSIOL-REG I, V298, pR266, DOI 10.1152/ajpregu.00471.2009
   Mannerås L, 2007, ENDOCRINOLOGY, V148, P3781, DOI 10.1210/en.2007-0168
   Maranon R, 2015, AM J PHYSIOL-REG I, V308, pR708, DOI 10.1152/ajpregu.00411.2014
   Maranon RO, 2016, PHYSIOL REP, V4, DOI 10.14814/phy2.12669
   Maranon RO, 2014, AM J PHYSIOL-REG I, V306, pR248, DOI 10.1152/ajpregu.00490.2013
   Mathis KW, 2012, HYPERTENSION, V59, P673, DOI 10.1161/HYPERTENSIONAHA.111.190009
   Mosca L, 2007, J AM COLL CARDIOL, V49, P1230, DOI [10.1016/j.jacc.2007.02.020, 10.1161/CIRCULATIONAHA.107.181546]
   Nautiyal M, 2012, HYPERTENSION, V60, P1257, DOI 10.1161/HYPERTENSIONAHA.112.196782
   Ong KL, 2007, HYPERTENSION, V49, P69, DOI 10.1161/01.HYP.0000252676.46043.18
   POLDERMAN KH, 1993, ANN INTERN MED, V118, P429, DOI 10.7326/0003-4819-118-6-199303150-00006
   Prelevic GM, 2002, FERTIL STERIL, V77, P945, DOI 10.1016/S0015-0282(02)03078-9
   Reckelhoff JF, 1998, HYPERTENSION, V31, P435, DOI 10.1161/01.HYP.31.1.435
   Reckelhoff JF, 2004, HYPERTENSION, V43, P918, DOI 10.1161/01.HYP.0000124670.03674.15
   Reckelhoff JF, 2000, HYPERTENSION, V35, P480, DOI 10.1161/01.HYP.35.1.480
   Reckelhoff JF, 2012, WOMEN AND HLTH
   Rodriguez-Iturbe B, 2017, PHYSIOL REV, V97, P1127, DOI 10.1152/physrev.00031.2016
   Roman RJ, 2002, PHYSIOL REV, V82, P131, DOI 10.1152/physrev.00021.2001
   Romero JC, 1999, HYPERTENSION, V34, P943, DOI 10.1161/01.HYP.34.4.943
   Routledge FS, 2009, CAN J CARDIOL, V25, pE157, DOI 10.1016/S0828-282X(09)70089-3
   Sarganas G, 2016, HYPERTENS RES, V39, P457, DOI 10.1038/hr.2016.5
   Sartori-Valinotti JC, 2008, HYPERTENSION, V51, P1170, DOI 10.1161/HYPERTENSIONAHA.107.106922
   Schnackenberg CG, 1998, HYPERTENSION, V32, P59, DOI 10.1161/01.HYP.32.1.59
   Seaberg EC, 2005, AIDS, V19, P953, DOI 10.1097/01.aids.0000171410.76607.f8
   Sedeek M, 2008, AM J HYPERTENS, V21, P1152, DOI 10.1038/ajh.2008.239
   Stepp DW, 2013, PHYSIOL REP, V1, DOI 10.1002/phy2.146
   Stolarz K, 2002, J HYPERTENS, V20, P2131, DOI 10.1097/00004872-200211000-00006
   Sullivan JC, 2007, AM J PHYSIOL-REG I, V292, pR764, DOI 10.1152/ajpregu.00322.2006
   Swart R, 2017, BMC CARDIOVASC DISOR, V17, DOI 10.1186/s12872-017-0538-x
   Taylor EB, 2017, J AM HEART ASSOC, V27, P6
   Tipton AJ, 2012, AM J PHYSIOL-REG I, V303, pR359, DOI 10.1152/ajpregu.00246.2012
   Tyson CC, 2017, NEPHRON, V135, P287, DOI 10.1159/000455130
   Venegas-Pont M, 2010, AM J HYPERTENS, V23, P92, DOI 10.1038/ajh.2009.203
   VERDECCHIA P, 1994, HYPERTENSION, V24, P793, DOI 10.1161/01.HYP.24.6.793
   WEINER CP, 1994, P NATL ACAD SCI USA, V91, P5212, DOI 10.1073/pnas.91.11.5212
   Wenger NK, 2016, AM J MED, V29, P1030
   Xue BJ, 2005, AM J PHYSIOL-HEART C, V288, pH2177, DOI 10.1152/ajpheart.00969.2004
   Yanes L, 2005, AM J PHYSIOL-REG I, V288, pR903, DOI 10.1152/ajpregu.00530.2004
   Yanes LL, 2006, AM J PHYSIOL-REG I, V291, pR383, DOI 10.1152/ajpregu.00510.2005
   Yanes LL, 2011, AM J PHYSIOL-REG I, V300, P1543, DOI 10.1152/ajpregu.00387.2010
   Yanes LL, 2011, GENDER MED, V8, P103, DOI 10.1016/j.genm.2010.11.013
   Yanes LL, 2005, AM J PHYSIOL-REG I, V288, pR229, DOI 10.1152/ajpregu.00697.2003
   Yi XY, 2016, STROKE, V47, P3045, DOI 10.1161/STROKEAHA.116.015146
   Yi XY, 2016, J ATHEROSCLER THROMB, V23, P1286, DOI 10.5551/jat.35279
   Zhang F, 2005, CELL RES, V15, P717, DOI 10.1038/sj.cr.7290341
   Zimmerman MA, 2014, AM J PHYSIOL-RENAL, V306, pF1136, DOI 10.1152/ajprenal.00677.2013
   Zu LY, 2016, THROMB RES, V144, P192, DOI 10.1016/j.thromres.2016.06.031
   ,, 2015, New England Journal of Medicine, V373, P2103, DOI 10.1056/NEJMoa1511939
NR 81
TC 40
Z9 41
U1 1
U2 7
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 0065-2598
EI 2214-8019
BN 978-3-319-77932-4; 978-3-319-77931-7
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2018
VL 1065
BP 139
EP 151
DI 10.1007/978-3-319-77932-4_9
D2 10.1007/978-3-319-77932-4
PG 13
WC Biology; Cardiac & Cardiovascular Systems; Medicine, Research &
   Experimental
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Cardiovascular System &
   Cardiology; Research & Experimental Medicine
GA BL6GX
UT WOS:000453874000011
PM 30051382
DA 2025-06-11
ER

PT J
AU Lee, K
   Ko, DH
   Lee, JY
AF Lee, Kyujin
   Ko, Duk Han
   Lee, Ji Young
TI Prevalence of Metabolic Syndrome According to Causes of Physical
   Activity Limitation
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE metabolic syndrome; physical activity limitation; prevalence
ID UNITED-STATES; RISK-FACTORS; DISEASE; DISABILITY; OBESITY; INTERVENTION;
   PREVENTION; DEPRESSION; INACTIVITY; PEOPLE
AB Purpose: One cause of metabolic syndrome (MetS) is inactivity. This study analyzed the prevalence of MetS due to causes of activity limitation (AL) in adults over 40 years old.
   Paticipants and Methods: Participants included 2885 people aged 40-79 (1198 men and 1687 women) who completed the Korean National Health and Nutrition Survey (KNHANES) conducted between 2013 and 2017. They were divided into two groups based on age: the middle age group (MA) included 1148 total participants, 515 men and 633 women from 40-59 years old; the older age group (OA) included 1737 total participants, 683 men and 1054 women from 60-79 years old. MetS was diagnosed according to the Third Report of the National Cholesterol Education Program and the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (NCEP-ATP III). Logistic regression was conducted to calculate the odds ratio for MetS prevalence.
   Results: The prevalence of MetS in people with AL increased 1.432-fold in the MA men group, 1.511-fold in the OA men group, 1.546-fold in the MA women group, and 1.565-fold in the OA women group. There were several causes of AL; people with physical activity for diabetes mellitus and hypertension increased MetS prevalence in both sexes and all age groups: MA men group (OR=3.216, 95% CI=1.852-7.354, P=0.034), MA women group (OR=2.159, 95% CI=1.854-5.346, P=0.032), OA men group (OR=3.200, 95% CI=1.235-7.841, P=0.009), and OA women group (OR=3.444, 95% CI=1.310-6.627, P=0.008). Also, mental problems in the MA men group (OR=2.284, 95% CI=1.591-4.986, P=0.012) and OA men group (OR=1.149, 95% CI=1.017-2.941, P=0.012), and musculoskeletal problems in the MA women group (OR=1.784, 95% CI=1.102-2.902, P=0.021) and OA women group (OR=1.459, 95% CI=1.054-1.993, P=0.004) increased the prevalence.
   Conclusion: The prevalence of MetS due to activity limitation was increased in MA and OA groups. Activity limitation increased the MetS prevalence from 1.4- to 1.5-times, Therefore, to prevent metabolic syndrome, physical activity should be increased, and guidelines should be presented according to the activity limitation causes, age, and sex.
C1 [Lee, Kyujin] Seoul Natl Univ, Inst Sports Sci, Seoul, South Korea.
   [Ko, Duk Han] Dongguk Univ, Dept Sports Sci Convergence, Seoul, South Korea.
   [Lee, Ji Young] Gangneung Wonju Natl Univ, Dept Phys Educ, Kangnung, South Korea.
C3 Seoul National University (SNU); Dongguk University; Gangneung-Wonju
   National University
RP Ko, DH (corresponding author), Dongguk Univ, Dept Sports Sci Convergence, Seoul, South Korea.; Lee, JY (corresponding author), Gangneung Wonju Natl Univ, Dept Phys Educ, Kangnung, South Korea.
EM kodh119@hanmail.net; jylee@gwnu.ac.kr
FU Ministry of Education of the Republic of Korea; National Research
   Foundation of Korea [NRF-2020S1A5A8043065]
FX This work was supported by the Ministry of Education of the Republic of
   Korea and the National Research Foundation of
   Korea(NRF-2020S1A5A8043065).
CR ACSM, 2017, ACSMS EX TEST PRESCR
   Ada L, 2006, DISABIL REHABIL, V28, P891, DOI 10.1080/09638280500535165
   Balchin R, 2016, J AFFECT DISORDERS, V200, P218, DOI 10.1016/j.jad.2016.04.030
   Balzi D, 2010, AGE AGEING, V39, P92, DOI 10.1093/ageing/afp209
   Barbour KE, 2017, MMWR-MORBID MORTAL W, V66, P246, DOI 10.15585/mmwr.mm6609e1
   Tran BT, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-016-3936-6
   Cardiovascular A, 2013, GUID CARD REH SEC PR
   Chen PE, 2019, J MENS HEALTH, V15, pE1, DOI 10.22374/jomh.v15i2.106
   Cho KK, 2019, J MENS HEALTH, V15, pE46, DOI 10.22374/jomh.v15i3.152
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   Chow CK, 2016, HEART LUNG CIRC, V25, P802, DOI 10.1016/j.hlc.2016.04.009
   Cockerham W.C., 2016, Sociology of mental disorder
   Colberg SR, 2016, DIABETES CARE, V39, P2065, DOI 10.2337/dc16-1728
   Diaz KM, 2013, CURR HYPERTENS REP, V15, P659, DOI 10.1007/s11906-013-0386-8
   Dinas PC, 2011, IRISH J MED SCI, V180, P319, DOI 10.1007/s11845-010-0633-9
   Edwardson CL, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034916
   Fidler Carrie, 2011, J Med Econ, V14, P646, DOI 10.3111/13696998.2011.610852
   Grundy SM, 2016, TRENDS CARDIOVAS MED, V26, P364, DOI 10.1016/j.tcm.2015.10.004
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Guthold R, 2018, LANCET GLOB HEALTH, V6, pE1077, DOI [10.1016/S2214-109X(18)30357-7, 10.1016/s2214-109x(18)30357-7]
   Hoy D, 2010, BEST PRACT RES CL RH, V24, P769, DOI 10.1016/j.berh.2010.10.002
   KCDC, 2019, 2017 KOR HLTH STAT
   KMCST, 2018, 2018 KOR PART SPORTS
   Kotseva K, 2016, EUR J PREV CARDIOL, V23, P2007, DOI 10.1177/2047487316667784
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lee SY, 2007, DIABETES RES CLIN PR, V75, P72, DOI 10.1016/j.diabres.2006.04.013
   Lin FR, 2012, ARCH INTERN MED, V172, P369, DOI 10.1001/archinternmed.2011.728
   Lord SR, 2010, CLIN GERIATR MED, V26, P569, DOI 10.1016/j.cger.2010.06.002
   Martin SB, 2000, MED SCI SPORT EXER, V32, P2087, DOI 10.1097/00005768-200012000-00019
   Miller ME, 2000, J AM GERIATR SOC, V48, P1264, DOI 10.1111/j.1532-5415.2000.tb02600.x
   Monson Angela L, 2017, J Dent Hyg, V91, P15
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Murrock CJ, 2014, J AGING PHYS ACTIV, V22, P380, DOI [10.1123/JAPA.2013-0003, 10.1123/japa.2013-0003]
   Nguyen AM, 2015, BMC GERIATR, V15, DOI 10.1186/s12877-015-0062-8
   Plooij B, 2012, J CLIN NURS, V21, P3002, DOI 10.1111/j.1365-2702.2011.03856.x
   Romano M, 2015, CLIN PSYCHOL REV, V38, P1, DOI 10.1016/j.cpr.2015.02.008
   Rooth DO, 2011, LABOUR ECON, V18, P399, DOI 10.1016/j.labeco.2010.11.006
   Slater M, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-77
   Sparling PB, 2000, HEALTH EDUC RES, V15, P367, DOI 10.1093/her/15.3.367
   Tamura F, 2012, DYSPHAGIA, V27, P556, DOI 10.1007/s00455-012-9407-z
   Teychenne M, 2011, INT J BEHAV MED, V17, P246, DOI 10.1007/s12529-010-9075-z
   Thomsen M, 2014, JAMA INTERN MED, V174, P15, DOI 10.1001/jamainternmed.2013.10522
   Toniazzo MP, 2018, CLIN NUTR, V37, P824, DOI 10.1016/j.clnu.2017.03.014
   Villanueva R, 2016, EUR J PUBLIC HEALTH, V26, P267, DOI 10.1093/eurpub/ckv215
   Wheaton AG, 2015, MMWR-MORBID MORTAL W, V64, P289
   WHO, 2008, WHO STEPWISE APPR SU
   Wu CH, 2010, ARCH GERONTOL GERIAT, V50, pS6, DOI 10.1016/S0167-4943(10)70004-2
NR 47
TC 4
Z9 4
U1 5
U2 15
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2020
VL 13
BP 2455
EP 2463
DI 10.2147/DMSO.S257063
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA MK3XH
UT WOS:000548715800001
PM 32765024
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Acosta, D
   Rottbeck, R
   Rodríguez, JG
   González, LM
   Almánzar, MR
   Minaya, SN
   Ortiz, MD
   Ferri, CP
   Prince, MJ
AF Acosta, Daisy
   Rottbeck, Ruth
   Rodriguez, Juana G.
   Gonzalez, Loida M.
   Almanzar, Mary R.
   Minaya, Susana N.
   Ortiz, Maria del C.
   Ferri, Cleusa P.
   Prince, Martin J.
TI The prevalence and social patterning of chronic diseases among older
   people in a population undergoing health transition. A 10/66 Group
   cross-sectional population-based survey in the Dominican Republic
SO BMC PUBLIC HEALTH
LA English
DT Article
ID MIDDLE-INCOME COUNTRIES; RISK-FACTORS; METABOLIC SYNDROME;
   SOCIOECONOMIC-STATUS; NATIONAL-HEALTH; UNITED-STATES; US ADULTS;
   DEMENTIA; TRENDS; EPIDEMIOLOGY
AB Background: Very little of the increased attention towards chronic diseases in countries with low and middle incomes has been directed towards older people, who contribute 72% of all deaths, and 14% of all Disability Adjusted Life Years linked to this group of conditions in those regions. We aimed to study the prevalence of physical, mental and cognitive diseases and impairments among older people in the Dominican Republic, their social patterning, and their relative contributions to disability.
   Methods: A cross-sectional catchment area one-phase survey of chronic disease diagnoses, physical impairments, risk factors and associated disability among 2011 people aged 65 years and over (of whom 1451 gave fasting blood samples) in Santo Domingo, Dominican Republic.
   Results: The most prevalent diagnoses were hypertension (73.0%), anaemia (35.0%), diabetes (17.5%), depression (13.8%) and dementia (11.7%), with 39.6% meeting criteria for metabolic syndrome. After direct standardization (for age and sex) the prevalences of stroke (standardized morbidity ratio [SMR] 100) and hypertension (SMR 108) were similar to those in the United States of America National Health and Nutrition Examination Survey (NHANES reference SMR 100), while those of diabetes (SMR 83) and metabolic syndrome (SMR 72) were somewhat lower. Anaemia was three times more common than in the USA (SMR 310). Diabetes, hypertension, dyslipidaemia, obesity and the metabolic syndrome were associated with affluence and female sex. Arthritis, anaemia, dementia and stroke were strongly age-associated and these conditions were also the main independent contributors to disability.
   Conclusions: The prevalence of many chronic diseases is similar in predominately low socioeconomic status neighbourhoods in the Dominican Republic to that in the USA. Prevalence of age-associated conditions is likely to increase with demographic ageing. There is also scope for increases in cardiovascular disease prevalence, if, as observed in other settings undergoing the epidemiologic transition, the burden of risk factors shifts towards the less affluent. Monitoring future trends in the prevalence and social patterning of chronic diseases may help to assess the effectiveness and equity of primary and secondary prevention strategies. Specific recommendations from our research include identifying and targeting the causes of anaemia among older people, and addressing women's health disadvantages.
C1 [Prince, Martin J.] Inst Psychiat P060, Hlth Serv & Populat Res Dept, London SE5 8AF, England.
   [Acosta, Daisy] Univ Nacl Pedro Henriquez Urena, Geriatr Sect, Dept Internal Med, Santo Domingo, Dominican Rep.
   [Rottbeck, Ruth] Univ Butare, Ctr Hosp, Butare, Rwanda.
   [Rodriguez, Juana G.] Minist Salud Publ & Asistencia, Social Direcc, Area Salud 6, Santo Domingo, Dominican Rep.
   [Gonzalez, Loida M.; Almanzar, Mary R.; Minaya, Susana N.; Ortiz, Maria del C.] Lab Nacl Dr Defillo, Santo Domingo, Dominican Rep.
C3 University of London; King's College London; Universidad Nacional Pedro
   Henriquez Urena
RP Prince, MJ (corresponding author), Inst Psychiat P060, Hlth Serv & Populat Res Dept, De Crespigny Pk, London SE5 8AF, England.
EM martin.prince@kcl.ac.uk
RI Prince, Martin/A-9170-2010; Rodriguez, JUANA/G-3347-2013; ferri,
   cleusa/B-2922-2010
OI Prince, Martin/0000-0003-1379-7146; Rodriguez,
   JUANA/0000-0003-3172-9171; ferri, cleusa/0000-0002-1815-7685
FU Wellcome Trust; World Health Organisation; US Alzheimer's Association
FX The 10/66 Dementia Research Group's research has been funded by the
   Wellcome Trust Health Consequences of Population Change Programme
   (GR066133-Prevalence phase in Cuba and Brazil; GR08002-Incidence phase
   in Peru, Mexico, Argentina, Cuba, Dominican Republic, Venezuela and
   China), the World Health Organisation (India, Dominican Republic and
   China), the US Alzheimer's Association (IIRG-04-1286-Peru, Mexico and
   Argentina), and FONDACIT (Venezuela). The Rockefeller Foundation
   supported our recent dissemination meeting at their Bellagio Centre.
   None of the sponsors or funders of this study had any involvement in
   this publication.
CR Acosta D, 2008, BMC PUBLIC HEALTH, V8, DOI 10.1186/1471-2458-8-285
   [Anonymous], 1994, Diagnostic and Statistical Manual of Mental Disorders, V4th
   [Anonymous], 2000, Towards an international consensus on policy for long-term care of the ageing
   *CENTR INT AG, 2008, WORLD FACTB DOM REP
   COPELAND JRM, 1986, PSYCHOL MED, V16, P89, DOI 10.1017/S0033291700057779
   Cowie CC, 2006, DIABETES CARE, V29, P1263, DOI 10.2337/dc06-0062
   Deepa M, 2003, J Assoc Physicians India, V51, P863
   Fleischer NL, 2008, J URBAN HEALTH, V85, P923, DOI 10.1007/s11524-008-9319-2
   Ford ES, 2005, DIABETES CARE, V28, P2745, DOI 10.2337/diacare.28.11.2745
   Fuster V, 2005, LANCET, V366, P1512, DOI 10.1016/S0140-6736(05)67610-6
   Ganguli M, 1996, Int Psychogeriatr, V8, P507, DOI 10.1017/S1041610296002852
   GEORGE LK, 1985, J AM GERIATR SOC, V33, P607, DOI 10.1111/j.1532-5415.1985.tb06317.x
   Guralnik JM, 2004, BLOOD, V104, P2263, DOI 10.1182/blood-2004-05-1812
   HALL KS, 1993, INT J METHOD PSYCH, V3, P1
   Hofman K, 2006, J MED LIBR ASSOC, V94, P415
   Horton R, 2005, LANCET, V366, P1514, DOI 10.1016/S0140-6736(05)67454-5
   Horton R, 2007, LANCET, V370, P1881, DOI 10.1016/S0140-6736(07)61701-2
   House JS, 2005, J GERONTOL B-PSYCHOL, V60, P15
   Kanjilal S, 2006, ARCH INTERN MED, V166, P2348, DOI 10.1001/archinte.166.21.2348
   Lobo A, 2000, NEUROLOGY, V54, pS4
   Loucks EB, 2007, ANN EPIDEMIOL, V17, P782, DOI 10.1016/j.annepidem.2007.05.003
   Monteiro CA, 2004, B WORLD HEALTH ORGAN, V82, P940
   Monteiro CA, 2007, AM J PUBLIC HEALTH, V97, P1808, DOI 10.2105/AJPH.2006.099630
   *NAT HEART LABI, 2007, MOB MORT 2007 CHART
   Ng N, 2006, SCAND J PUBLIC HEALT, V34, P199, DOI 10.1080/14034940500204506
   Ong KL, 2007, HYPERTENSION, V49, P69, DOI 10.1161/01.HYP.0000252676.46043.18
   Ostchega Y, 2007, J AM GERIATR SOC, V55, P1056, DOI 10.1111/j.1532-5415.2007.01215.x
   Prince M, 2003, LANCET, V361, P909, DOI 10.1016/S0140-6736(03)12772-9
   Prince M, 2008, INT REV PSYCHIATR, V20, P332, DOI 10.1080/09540260802094712
   Prince M, 2007, BMC PUBLIC HEALTH, V7, DOI 10.1186/1471-2458-7-165
   Regitz-Zagrosek V, 2007, GENDER MED, V4, pS162, DOI 10.1016/S1550-8579(07)80056-8
   Rehm J., 1999, International Journal of Methods in Psychiatric Research, V8, P110, DOI DOI 10.1002/MPR.61
   Rodriguez JJL, 2008, LANCET, V372, P464, DOI 10.1016/S0140-6736(08)61002-8
   Schargrodsky H, 2008, AM J MED, V121, P58, DOI 10.1016/j.amjmed.2007.08.038
   Singh R, 2007, DIABETIC MED, V24, P195, DOI 10.1111/j.1464-5491.2007.02066.x
   Smith KV, 2007, SOC SCI MED, V65, P1372, DOI 10.1016/j.socscimed.2007.05.023
   World Health Organization, 2006, WHO STAT INF SYST WO
   Yusuf S, 2001, CIRCULATION, V104, P2746, DOI 10.1161/hc4601.099487
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
   Zimmer Z, 2001, SOC SCI MED, V52, P1297, DOI 10.1016/S0277-9536(00)00232-X
NR 40
TC 19
Z9 22
U1 1
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD JUN 16
PY 2010
VL 10
AR 344
DI 10.1186/1471-2458-10-344
PG 17
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 650KK
UT WOS:000281848000001
PM 20553582
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yin, HM
   Lu, BL
   Zeng, K
   Li, Y
   Ma, J
AF Yin, Huimin
   Lu, Baili
   Zeng, Kuan
   Li, Yi
   Ma, Jun
TI Prevalence and factors associated with dyslipidemia in patients with
   first hospitalization for major depressive disorder: a large sample
   cross-sectional study
SO BMC PSYCHIATRY
LA English
DT Article
DE Major depressive disorder; Hyperlipidemia; First hospitalization
ID METABOLIC SYNDROME; SERUM-CHOLESTEROL; PATHOPHYSIOLOGY; SYMPTOMS;
   STRESS; PEOPLE
AB Background Major depressive disorder (MDD) is a severe mental illness with high relapse rates and high mortality. Depression not only severely limits psychosocial functioning but also reduces quality of life. It can also negatively affect patients' clinical parameters, including lipid metabolism markers. This study aimed to investigate the prevalence and risk factors of hyperlipidemia (HL) in patients with MDD who were hospitalized for the first time.Methods In this study, we enrolled 981 patients with MDD who were hospitalized for the first time, collected their demographic data and biochemical indicators, and evaluated their clinical symptoms. We divided the patients into HL and non-HL subgroups based on whether they had co-morbid HL. We compared whether there were significant differences between the two groups regarding demographics and general clinical information.Results A total of 708 of 981 MDD patients were described as being in the hyperlipidemic group, with an incidence of 72.17%. Clinical Global Impression Scale-Severity of Illness (CGI-SI) score and Hamilton Depression Scale (HAMD) score are risk factors for co-morbid HL in patients with MDD. The area under the ROC curve for the CGI-SI and HAMD score and their combined discriminatory ability was approximately 63%, 67%, and 68%, respectively.Conclusion The prevalence of HL was high in patients with MDD who were first hospitalized; Higher HAMD score and CGI-SI score were risk factors for the development of HL in MDD; The HAMD score and the CGI-SI score are predictive of the severity of HL.
C1 [Yin, Huimin; Lu, Baili; Zeng, Kuan; Li, Yi] Wuhan Mental Hlth Ctr, Dept Psychiat, 89 Gongnongbing Rd, Wuhan, Hubei, Peoples R China.
   [Ma, Jun] Wuhan Univ, Dept Psychiat, Renmin Hosp, 99 Zhangzhidong Rd, Wuhan, Hubei, Peoples R China.
C3 Wuhan University
RP Li, Y (corresponding author), Wuhan Mental Hlth Ctr, Dept Psychiat, 89 Gongnongbing Rd, Wuhan, Hubei, Peoples R China.; Ma, J (corresponding author), Wuhan Univ, Dept Psychiat, Renmin Hosp, 99 Zhangzhidong Rd, Wuhan, Hubei, Peoples R China.
EM psylee@163.com; majun0313@wo.cn
RI Ma, Jun/HLV-7600-2023
CR Baek JH, 2014, PROG NEURO-PSYCHOPH, V51, P113, DOI 10.1016/j.pnpbp.2014.01.018
   Barinas-Mitchell E, 2021, J PSYCHOSOM RES, V148, DOI 10.1016/j.jpsychores.2021.110551
   Beaupere C, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22020623
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   Bekhbat M, 2018, PSYCHONEUROENDOCRINO, V98, P222, DOI 10.1016/j.psyneuen.2018.09.004
   Beydoun MA, 2023, J AFFECT DISORDERS, V333, P447, DOI 10.1016/j.jad.2023.04.083
   Bhatt S, 2020, DRUG DISCOV TODAY, V25, P1270, DOI 10.1016/j.drudis.2020.05.001
   Cho Y, 2022, BMJ OPEN, V12, DOI 10.1136/bmjopen-2020-048233
   Crouse JJ, 2021, LANCET PSYCHIAT, V8, P813, DOI 10.1016/S2215-0366(21)00034-1
   Dregan A, 2020, JAMA PSYCHIAT, V77, P598, DOI 10.1001/jamapsychiatry.2019.4712
   Du X, 2015, FRONT PSYCHIATRY, V6, DOI 10.3389/fpsyt.2015.00032
   Elovainio M, 2010, HEALTH PSYCHOL, V29, P237, DOI 10.1037/a0018875
   Fouad GI, 2020, NEUROCHEM RES, V45, P1142, DOI 10.1007/s11064-020-02996-2
   Gui JF, 2024, BMC GERIATR, V24, DOI 10.1186/s12877-023-04650-2
   Hu JQ, 2023, FRONT PSYCHIATRY, V14, DOI 10.3389/fpsyt.2023.1085105
   Ignácio ZM, 2019, MOL NEUROBIOL, V56, P8323, DOI 10.1007/s12035-019-01670-1
   Jiang Y, 2023, BMC PSYCHIATRY, V23, DOI 10.1186/s12888-022-04511-z
   Kahl KG, 2012, EUR ARCH PSY CLIN N, V262, P313, DOI 10.1007/s00406-011-0277-4
   Li J, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-01314-7
   Li XY, 2023, BMC PSYCHIATRY, V23, DOI 10.1186/s12888-023-04536-y
   Li Y, 2022, EXP NEUROL, V348, DOI 10.1016/j.expneurol.2021.113949
   Lin J, 2023, J AFFECT DISORDERS, V331, P434, DOI 10.1016/j.jad.2023.03.046
   Liu XY, 2016, ANAL BIOANAL CHEM, V408, P6497, DOI 10.1007/s00216-016-9768-5
   Malhi GS, 2018, LANCET, V392, P2299, DOI 10.1016/S0140-6736(18)31948-2
   Maury E, 2014, DIABETES METAB, V40, P338, DOI 10.1016/j.diabet.2013.12.005
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   Meng RW, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2019.21043
   Nemeroff CB, 2020, AM J PSYCHIAT, V177, P671, DOI 10.1176/appi.ajp.2020.20060845
   Papakostas GI, 2003, NEUROPSYCHOBIOLOGY, V47, P146, DOI 10.1159/000070584
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Pinto B, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23042032
   Poznyak A, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21051835
   Rydin AO, 2023, PSYCHOL MED, V53, P7385, DOI 10.1017/S0033291723001009
   Schuch F, 2017, J AFFECT DISORDERS, V210, P139, DOI 10.1016/j.jad.2016.10.050
   Simon MS, 2021, PROG NEURO-PSYCHOPH, V111, DOI 10.1016/j.pnpbp.2021.110391
   Sowa-Kucma M, 2018, NEUROTOX RES, V33, P448, DOI 10.1007/s12640-017-9835-5
   Su X, 2022, CLIN CHIM ACTA, V527, P61, DOI 10.1016/j.cca.2022.01.006
   Tang R, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00340
   Tresaco B, 2009, OBESITY, V17, P1086, DOI 10.1038/oby.2008.626
   Vilibic M, 2014, CROAT MED J, V55, P520, DOI 10.3325/cmj.2014.55.520
   Wagner CJ, 2019, PROG NEURO-PSYCHOPH, V92, P405, DOI 10.1016/j.pnpbp.2019.01.010
   Yan LJ, 2022, PSYCHIAT RES, V317, DOI 10.1016/j.psychres.2022.114864
   Yu HN, 2021, FOOD FUNCT, V12, P6416, DOI [10.1039/D1FO00044F, 10.1039/d1fo00044f]
   Zhang M, 2018, INT J CARDIOL, V260, P196, DOI 10.1016/j.ijcard.2017.12.069
   Zhang M, 2021, TRANSL PSYCHIAT, V11, DOI 10.1038/s41398-021-01759-z
   Zhao YJ, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.659470
   Zhu JR, 2018, J GERIATR CARDIOL, V15, P1, DOI 10.11909/j.issn.1671-5411.2018.01.011
   Zhu QF, 2023, FRONT PSYCHIATRY, V14, DOI 10.3389/fpsyt.2023.1101865
   Zuo CC, 2022, REDOX BIOL, V58, DOI 10.1016/j.redox.2022.102522
NR 49
TC 0
Z9 0
U1 2
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD MAY 27
PY 2024
VL 24
IS 1
AR 396
DI 10.1186/s12888-024-05848-3
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA SE8E8
UT WOS:001232865600002
PM 38802840
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Simoons, M
   Mulder, H
   Doornbos, B
   Schoevers, RA
   van Roon, EN
   Ruhé, HG
AF Simoons, Mirjam
   Mulder, Hans
   Doornbos, Bennard
   Schoevers, Robert A.
   van Roon, Eric N.
   Ruhe, Henricus G.
TI Monitoring of somatic parameters at outpatient departments for mood and
   anxiety disorders
SO PLOS ONE
LA English
DT Article
ID MAJOR DEPRESSIVE DISORDER; METABOLIC SYNDROME; BIPOLAR DISORDER;
   GUIDELINES; RISK; PEOPLE; SCHIZOPHRENIA; RECOMMENDATIONS;
   ANTIPSYCHOTICS; METAANALYSIS
AB Introduction
   Somatic complications account for the majority of the 13-30 years shortened life expectancy in psychiatric patients compared to the general population. The study aim was to assess to which extent patients visiting outpatient departments for mood and anxiety disorders were monitored for relevant somatic comorbidities and (adverse) effects of psychotropic drugs-more specifically a) metabolic parameters, b) lithium safety and c) ECGs-during their treatment.
   Methods
   We performed a retrospective clinical records review and cross-sectional analysis to assess the extent of somatic monitoring at four outpatient departments for mood and anxiety disorders in The Netherlands. We consecutively recruited adult patients visiting a participating outpatient department between March and November 2014. The primary outcome was percentage of patients without monitoring measurements. Secondary outcomes were number of measurements per parameter per patient per year and time from start of treatment to first measurement.
   Results
   We included 324 outpatients, of whom 60.2% were female. Most patients were treated for depressive disorders (39.8%), anxiety disorders (16.7%) or bipolar or related disorders (11.7%) and 198 patients (61.1%) used at least one psychotropic drug. For 186 patients (57.4%), no monitoring records were recorded (median treatment period 7.3 months, range 0-55.6). The median number of measurements per parameter per year since the start of outpatient treatment for patients with monitoring measurements was 0.31 (range 0.0-12.9). The median time to first monitoring measurement per parameter for patients with monitoring measurements was 3.8 months (range 0.0-50.7).
   Discussion
   Somatic monitoring in outpatients with mood and anxiety disorders is not routine clinical practice. Monitoring practices need to be improved to prevent psychiatric outpatients from undetected somatic complications.
C1 [Simoons, Mirjam; Mulder, Hans] Wilhelmina Hosp Assen, Dept Clin Pharm, Assen, Netherlands.
   [Simoons, Mirjam; Schoevers, Robert A.; Ruhe, Henricus G.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Interdisciplinary Ctr Psychopathol & Emot Regulat, Groningen, Netherlands.
   [Simoons, Mirjam; van Roon, Eric N.] Univ Groningen, Dept Pharmacotherapy Epidemiol & Econ, Dept Pharm, Groningen, Netherlands.
   [Mulder, Hans; Doornbos, Bennard] Mental Hlth Serv Drenthe, Assen, Netherlands.
   [van Roon, Eric N.] Med Ctr Leeuwarden, Dept Clin Pharm & Clin Pharmacol, Leeuwarden, Netherlands.
   [Ruhe, Henricus G.] Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford, England.
C3 University of Groningen; University of Groningen; Medical Center
   Leeuwarden; University of Oxford
RP Mulder, H (corresponding author), Wilhelmina Hosp Assen, Dept Clin Pharm, Assen, Netherlands.; Mulder, H (corresponding author), Mental Hlth Serv Drenthe, Assen, Netherlands.
EM hans.mulder@wza.nl
RI van Roon, Eric/O-2112-2013; Ruhe, Henricus/K-8764-2012
OI Schoevers, Robert A/0000-0003-0760-9866
FU Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO)/ZonMW VENI
   [016.126.059]
FX The author(s) received no specific funding for this work, but HGR is
   supported by a Nederlandse Organisatie voor Wetenschappelijk Onderzoek
   (NWO)/ZonMW VENI-Grant (https://www.zonmw.nl/en/research-and-results/
   fundamental-research/programmas/programme-detail/veni/), grant number
   #016.126.059. The funder had no role in study design, data collection
   and analysis, decision to publish, or preparation of the manuscript.
CR Bak M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094112
   Collins N, 2010, BMC PSYCHIATRY, V10, DOI 10.1186/1471-244X-10-80
   Correll CU, 2015, WORLD PSYCHIATRY, V14, P119, DOI 10.1002/wps.20204
   De Hert M, 2011, BRIT J PSYCHIAT, V199, P99, DOI 10.1192/bjp.bp.110.084665
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P138
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   Derijks HJ, 2008, EUR J CLIN PHARMACOL, V64, P531, DOI 10.1007/s00228-007-0441-y
   Dhamane AD, 2013, J PSYCHIATR PRACT, V19, P360, DOI 10.1097/01.pra.0000435035.45308.03
   Dodd S, 2012, CURR DRUG SAF, V7, P1, DOI 10.2174/157488612800492780
   Dodd S, 2011, AUST NZ J PSYCHIAT, V45, P712, DOI 10.3109/00048674.2011.595686
   Drye LT, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0098426
   Erlangsen A, 2017, LANCET PSYCHIAT, V4, P937, DOI 10.1016/S2215-0366(17)30429-7
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Jennex A, 2008, CAN J PSYCHIAT, V53, P34, DOI 10.1177/070674370805300106
   Katz MH, 2015, JAMA INT MED
   Lai CL, 2015, PHARMACOPSYCHIATRY, V48, P25, DOI 10.1055/s-0034-1394396
   Mangurian C., 2015, JAMA Intern Med, V175, P1
   Mitchell AJ, 2012, PSYCHOL MED, V42, P125, DOI 10.1017/S003329171100105X
   Morrato EH, 2010, ARCH GEN PSYCHIAT, V67, P17, DOI 10.1001/archgenpsychiatry.2009.179
   Najim H, 2012, BRIT J PSYCHIAT, V201, P75, DOI 10.1192/bjp.201.1.75b
   National Collaborating Centre for Mental Health (UK), 2006, AN NIC CLIN GUID
   National Institute for Clinical Excellence, 2014, RIM SEC CAR CLIN GUI
   Ng F, 2009, BIPOLAR DISORD, V11, P559, DOI 10.1111/j.1399-5618.2009.00737.x
   Paton C, 2013, BIPOLAR DISORD, V15, P865, DOI 10.1111/bdi.12128
   Romera I, 2010, J AFFECT DISORDERS, V127, P160, DOI 10.1016/j.jad.2010.05.009
   Sheeler RD, 2012, MAYO CLIN PROC, V87, P1042, DOI 10.1016/j.mayocp.2012.07.009
   Simon V, 2009, J CLIN PSYCHIAT, V70, P1041, DOI 10.4088/JCP.08r04392
   Simoons M, 2016, J CLIN PSYCHIAT, V77, P1511, DOI 10.4088/JCP.15m10376
   Sugawara N, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0086826
   Tosh G, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008298.pub2
   Vaccarino AL, 2008, J AFFECT DISORDERS, V110, P270, DOI 10.1016/j.jad.2008.01.009
   van Hasselt FM, 2013, BMC HEALTH SERV RES, V13, DOI 10.1186/1472-6963-13-426
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Zivin K, 2013, AM J PSYCHIAT, V170, P642, DOI 10.1176/appi.ajp.2013.12030408
   2004, J CLIN PSYCHIAT, V65, P267
NR 36
TC 6
Z9 6
U1 0
U2 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 21
PY 2018
VL 13
IS 8
AR e0200520
DI 10.1371/journal.pone.0200520
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA GR1HU
UT WOS:000442284500002
PM 30130372
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT S
AU Joe, Y
   Zheng, M
   Kim, SK
   Kim, S
   Uddin, JMD
   Min, TS
   Ryu, DG
   Chung, HT
AF Joe, Yeonsoo
   Zheng, Min
   Kim, Seul-Ki
   Kim, Sena
   Uddin, Jamal M. D.
   Min, Tae Sun
   Ryu, Do Gon
   Chung, Hun Taeg
BE Surh, YJ
   Song, YS
   Han, JY
   Jun, TW
   Na, HK
TI The role of carbon monoxide in metabolic disease
SO NUTRITION AND PHYSICAL ACTIVITY IN AGING, OBESITY, AND CANCER
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 2nd International Conference on Nutrition and Physical Activity in
   Aging, Obesity, and Cancer (NAPA 2011)
CY FEB 16-19, 2010-2011
CL Gyeongju, SOUTH KOREA
DE carbon monoxide; inflammation; ER stress; metabolic disease; heme
   oxygenase-1
ID UNFOLDED-PROTEIN RESPONSE; ENDOPLASMIC-RETICULUM-STRESS; IMPROVES
   INSULIN SENSITIVITY; ENDOTHELIAL-CELL APOPTOSIS; HEME OXYGENASE-1
   INDUCTION; ER STRESS; ACTIVATION; KINASE; INFLAMMATION; EXPRESSION
AB Metabolic disease is a complex disorder defined by various factors that increase the risk of cardiovascular disease and type 2 diabetes mellitus. In recent years, the incidence of chronic metabolic disease has dramatically increased throughout the world. These chronic metabolic diseases are associated with elevated inflammatory activities. In addition, endoplasmic reticulum (ER) stress leads to metabolic syndrome. Inflammation and ER stress are linked in the context of metabolic homeostasis and disease. Carbon monoxide (CO), a reaction product of heme oxygenase-1 (HO-1), reduces oxidative stress and inflammatory response and protects cells from ER stress. CO has anti-inflammatory effects via induction of HO-1 expression and prevents ER stress induced apoptosis by inhibiting the C/EBP homologous protein expression. In addition to its anti-inflammatory effects and antiapoptotic effects, HO-1 plays an important role in insulin release and glucose metabolism. In our study, inhalation of CO gas or CO-releasing molecule injection ameliorates 30% fructose or methionine-deficient- and choline-deficient diet-induced hepatic steatosis. Therefore, CO can be studied in the search for potential therapeutic targets for metabolic diseases via inhibition of inflammatory response and ER stress.
C1 [Joe, Yeonsoo; Kim, Seul-Ki; Kim, Sena; Uddin, Jamal M. D.; Chung, Hun Taeg] Univ Ulsan, Sch Biol Sci, Ulsan 680749, South Korea.
   [Zheng, Min] Univ Ulsan, Dept Med Sci, Ulsan 680749, South Korea.
   [Min, Tae Sun] Natl Res Fdn Korea, Div Nat Sci, Taejon, South Korea.
   [Ryu, Do Gon] Wonkwang Univ, Sch Oriental Med, Dept Physiol, Iksan, Chonbuk, South Korea.
C3 University of Ulsan; University of Ulsan; Wonkwang University
RP Chung, HT (corresponding author), Univ Ulsan, Sch Biol Sci, Bldg 35 Room 806,102 Daehak Ro, Ulsan 680749, South Korea.
EM chung@ulsan.ac.kr
RI Min, Taesun/AEP-1310-2022; Uddin, Md Jamal/W-3434-2017; Kim, You
   Sun/B-2881-2015
OI Uddin, Md Jamal/0000-0003-2911-3255; Kim, Sena/0000-0002-6930-2416
FU Korea Research Foundation; Korean Government (MOEHRD) [BRL-2009-0087350]
FX This work was supported by grants from the Korea Research Foundation
   Grant funded by the Korean Government (MOEHRD) (BRL-2009-0087350).
CR Akira S, 2004, NAT REV IMMUNOL, V4, P499, DOI 10.1038/nri1391
   Bertolotti A, 2000, NAT CELL BIOL, V2, P326, DOI 10.1038/35014014
   Brouard S, 2000, J EXP MED, V192, P1015, DOI 10.1084/jem.192.7.1015
   Chapman JT, 2001, AM J PHYSIOL-LUNG C, V281, pL209, DOI 10.1152/ajplung.2001.281.1.L209
   Chen X, 2002, J BIOL CHEM, V277, P13045, DOI 10.1074/jbc.M110636200
   Cullinan SB, 2003, MOL CELL BIOL, V23, P7198, DOI 10.1128/MCB.23.20.7198-7209.2003
   Cullinan SB, 2004, J BIOL CHEM, V279, P20108, DOI 10.1074/jbc.M314219200
   Di Pascoli M, 2006, BIOCHEM BIOPH RES CO, V340, P935, DOI 10.1016/j.bbrc.2005.12.082
   Harding HP, 2000, MOL CELL, V5, P897, DOI 10.1016/S1097-2765(00)80330-5
   Henningsson R, 1999, DIABETES, V48, P66, DOI 10.2337/diabetes.48.1.66
   Hidalgo C, 2005, PHILOS T R SOC B, V360, P2237, DOI 10.1098/rstb.2005.1759
   Hintze KJ, 2006, CELL MOL LIFE SCI, V63, P591, DOI 10.1007/s00018-005-5285-y
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Jeong GS, 2006, EXP MOL MED, V38, P393, DOI 10.1038/emm.2006.46
   Kaufman RJ, 2002, J CLIN INVEST, V110, P1389, DOI 10.1172/JC1200216886
   Kim KM, 2007, CIRC RES, V101, P919, DOI 10.1161/CIRCRESAHA.107.154781
   Lee AH, 2008, SCIENCE, V320, P1492, DOI 10.1126/science.1158042
   Lee BS, 2006, BIOCHEM BIOPH RES CO, V343, P965, DOI 10.1016/j.bbrc.2006.03.058
   Li M, 2008, DIABETES, V57, P1526, DOI 10.2337/db07-1764
   Matsukawa J, 2004, J BIOCHEM, V136, P261, DOI 10.1093/jb/mvh134
   MONCADA S, 1991, PHARMACOL REV, V43, P109
   Morse D, 2002, ANTIOXID REDOX SIGN, V4, P331, DOI 10.1089/152308602753666389
   Nakahira K, 2006, J EXP MED, V203, P2377, DOI 10.1084/jem.20060845
   Nicolai A, 2009, HYPERTENSION, V53, P508, DOI 10.1161/HYPERTENSIONAHA.108.124701
   Otterbein LE, 2000, NAT MED, V6, P422, DOI 10.1038/74680
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Petrache I, 2000, AM J PHYSIOL-LUNG C, V278, pL312, DOI 10.1152/ajplung.2000.278.2.L312
   Rivera CA, 2007, J HEPATOL, V47, P571, DOI 10.1016/j.jhep.2007.04.019
   Sarady JK, 2002, AM J RESP CELL MOL, V27, P739, DOI 10.1165/rcmb.4816
   Sidrauski C, 1997, CELL, V90, P1031, DOI 10.1016/S0092-8674(00)80369-4
   TENHUNEN R, 1968, P NATL ACAD SCI USA, V61, P748, DOI 10.1073/pnas.61.2.748
   Urano F, 2000, SCIENCE, V287, P664, DOI 10.1126/science.287.5453.664
   Wang XM, 2009, J IMMUNOL, V182, P3809, DOI 10.4049/jimmunol.0712437
   Wang XM, 2006, AM J RESP CELL MOL, V34, P434, DOI 10.1165/rcmb.2005-0376OC
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Werner ED, 1996, P NATL ACAD SCI USA, V93, P13797, DOI 10.1073/pnas.93.24.13797
   Ye J, 2000, MOL CELL, V6, P1355, DOI 10.1016/S1097-2765(00)00133-7
   Ye J, 1998, ENDOCRINOLOGY, V139, P4155, DOI 10.1210/en.139.10.4155
   Zhang KZ, 2004, J BIOL CHEM, V279, P25935, DOI 10.1074/jbc.R400008200
   Zheng X, 2005, ACTA PHARMACOL SIN, V26, P696, DOI 10.1111/j.1745-7254.2005.00105.x
NR 41
TC 12
Z9 13
U1 0
U2 4
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
BN 978-1-57331-842-6
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2011
VL 1229
BP 156
EP 161
DI 10.1111/j.1749-6632.2011.06121.x
PG 6
WC Endocrinology & Metabolism; Multidisciplinary Sciences; Nutrition &
   Dietetics
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Science & Technology - Other Topics;
   Nutrition & Dietetics
GA BWJ49
UT WOS:000294027800021
PM 21793851
OA Bronze
DA 2025-06-11
ER

PT J
AU Kaur, P
   Khan, H
   Grewal, AK
   Dua, K
   Singh, SK
   Gupta, G
   Singh, TG
AF Kaur, Parneet
   Khan, Heena
   Grewal, Amarjot Kaur
   Dua, Kamal
   Singh, Sachin Kumar
   Gupta, Gaurav
   Singh, Thakur Gurjeet
TI Exploring Therapeutic Strategies: The Relationship between Metabolic
   Disorders and FOXO Signalling in Alzheimer's Disease
SO CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
LA English
DT Review
DE Alzheimer's disease; FOXO; liver; diabetes; obesity; oxidative stress
ID GLYCOGEN-SYNTHASE KINASE-3; NEUROFIBRILLARY TANGLES; TRANSCRIPTION
   FACTORS; COGNITIVE IMPAIRMENT; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   PPAR-GAMMA; BETA; BRAIN; DROSOPHILA
AB Alzheimer's disease is an ailment that is linked with the degeneration of the brain cells, and this illness is the main cause of dementia. Metabolic stress affects the activity of the brain in AD via FOXO signaling. The occurrence of AD will significantly surge as the world's population ages, along with lifestyle changes perceived in current decades, indicating a main contributor to such augmented prevalence. Similarly, metabolic disorders of current adulthood, such as obesity, stroke, and diabetes mellitus, have been observed as the risk-causing factors of AD. Environmental influences induce genetic mutations that result in the development of several diseases. Metabolic disorders develop when individuals are exposed to an environment where food is easily accessible and requires minimal energy expenditure. Obesity and diabetes are among the most significant worldwide health concerns. Obesity arises because of an imbalance between the amount of energy consumed and the amount of energy expended, which is caused by both behavioral and physiological factors. Obesity, insulin resistance syndrome, hypertension, and inflammation are factors that contribute to the worldwide risk of developing diabetes mellitus and neurodegenerative diseases. FOXO transcription factors are preserved molecules that play an important part in assorted biological progressions, precisely in aging as well as metabolism. Apoptosis, cell division and differentiation, oxidative stress, metabolism, and lifespan are among the physiological processes that the FOXO proteins are adept at controlling. In this review, we explored the correlation between signaling pathways and the cellular functions of FOXO proteins. We have also summarized the intricate role of FOXO in AD, with a focus on metabolic stress, and discussed the prospect of FOXO as a molecular link between AD and metabolic disorders.
C1 [Kaur, Parneet; Khan, Heena; Grewal, Amarjot Kaur; Singh, Thakur Gurjeet] Chitkara Univ, Chitkara Coll Pharm, Patiala 140401, Punjab, India.
   [Dua, Kamal] Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, Sydney, NSW 2007, Australia.
   [Dua, Kamal] Univ Technol Sydney, Fac Hlth, Australian Res Ctr Complementary & Integrat Med, Ultimo, NSW 2007, Australia.
   [Singh, Sachin Kumar] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara 144411, Punjab, India.
   [Gupta, Gaurav] Suresh Gyan Vihar Univ, Sch Pharm, Mahal Rd, Jaipur 302017, India.
   [Gupta, Gaurav] Saveetha Univ, Saveetha Inst Med & Tech Sci, Ctr Transdisciplinary Res, Chennai, India.
   [Gupta, Gaurav] Graph Era Hill Univ, Sch Pharm, Dehra Dun 248007, India.
C3 Chitkara University, Punjab; University of Technology Sydney; University
   of Technology Sydney; Lovely Professional University; Saveetha Institute
   of Medical & Technical Science
RP Singh, TG (corresponding author), Chitkara Univ, Chitkara Coll Pharm, Patiala 140401, Punjab, India.
EM Gurjeet.singh@chitkara.edu.in
RI Gupta, Gaurav/AAX-4935-2020; SINGH, SACHIN/I-1948-2019; Khan,
   Heena/AHA-5804-2022; grewal, amarjot/HLQ-4585-2023; Singh, Dr. Thakur
   Gurjeet/AGV-7671-2022
OI Singh, Dr. Thakur Gurjeet/0000-0003-2979-1590
FU Chitkara College of Pharmacy, Chitkara University
FX The authors are grateful to the Chitkara College of Pharmacy, Chitkara
   University, Rajpura, Patiala, Punjab, India, for providing the necessary
   facilities to carry out the research work.
CR Abd-Elbaset M, 2020, N-S ARCH PHARMACOL, V393, P1611, DOI 10.1007/s00210-020-01863-9
   Ahmad M., 2020, MALAYS J SCI, V18
   Alam Q, 2016, CURR PHARM DESIGN, V22, P541, DOI 10.2174/1381612822666151125000300
   Anstey KJ, 2011, OBES REV, V12, pe426, DOI 10.1111/j.1467-789X.2010.00825.x
   Behl T, 2020, BIOMED PHARMACOTHER, V130, DOI 10.1016/j.biopha.2020.110714
   Bellelli G, 2009, J AM GERIATR SOC, V57, P178, DOI 10.1111/j.1532-5415.2009.02067.x
   Bellinger FP, 2008, J ALZHEIMERS DIS, V15, P465
   Bomfim TR, 2012, J CLIN INVEST, V122, P1339, DOI 10.1172/JCI57256
   Bonifacino JS, 2008, CURR OPIN CELL BIOL, V20, P427, DOI 10.1016/j.ceb.2008.03.009
   Brewster JL, 2006, MOL CELL NEUROSCI, V32, P242, DOI 10.1016/j.mcn.2006.04.006
   Burd CG, 2011, TRAFFIC, V12, P948, DOI 10.1111/j.1600-0854.2011.01188.x
   Cai H, 2012, CURR ALZHEIMER RES, V9, P5, DOI 10.2174/156720512799015064
   Cameron VA, 2006, HYPERTENSION, V47, P1155, DOI 10.1161/01.HYP.0000222893.85662.cd
   Claeysen S, 2012, CELL SIGNAL, V24, P1831, DOI 10.1016/j.cellsig.2012.05.008
   Cojocaru Inimioara Mihaela, 2011, Rom J Intern Med, V49, P55
   De Felice FG, 2014, ALZHEIMERS DEMENT, V10, pS26, DOI 10.1016/j.jalz.2013.12.004
   De Matteis MA, 2008, NAT REV MOL CELL BIO, V9, P273, DOI 10.1038/nrm2378
   De Strooper B, 2010, PHYSIOL REV, V90, P465, DOI 10.1152/physrev.00023.2009
   Ding HR, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.00177
   Dorvash M, 2020, INTERDISCIP SCI, V12, P1, DOI 10.1007/s12539-019-00347-6
   Du SQ, 2021, CELL BIOSCI, V11, DOI 10.1186/s13578-021-00700-7
   Garg C, 2022, PHARMACOL RES, V179, DOI 10.1016/j.phrs.2022.106194
   Garg N, 2022, BIOINTERFACE RES APP, V12, P1304, DOI 10.33263/BRIAC121.13041323
   Ghoneum MH, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/8845064
   Giannakou ME, 2004, SCIENCE, V305, P361, DOI 10.1126/science.1098219
   Gong YS, 2003, P NATL ACAD SCI USA, V100, P10417, DOI 10.1073/pnas.1834302100
   Greer EL, 2005, ONCOGENE, V24, P7410, DOI 10.1038/sj.onc.1209086
   Grewal AK, 2019, CAN J PHYSIOL PHARM, V97, P1094, DOI 10.1139/cjpp-2019-0188
   Gross DN, 2009, CURR DIABETES REP, V9, P208, DOI 10.1007/s11892-009-0034-5
   Gudala K, 2013, J DIABETES INVEST, V4, P640, DOI 10.1111/jdi.12087
   Harder H, 2004, DIABETES CARE, V27, P1915, DOI 10.2337/diacare.27.8.1915
   Hooper C, 2008, J NEUROCHEM, V104, P1433, DOI 10.1111/j.1471-4159.2007.05194.x
   Huang Y, 2010, BRIT J PHARMACOL, V159, P237, DOI 10.1111/j.1476-5381.2009.00517.x
   Hwangbo DS, 2004, NATURE, V429, P562, DOI 10.1038/nature02549
   Ishizawa T, 2003, AM J PATHOL, V163, P1057, DOI 10.1016/S0002-9440(10)63465-7
   Jope RS, 2004, TRENDS BIOCHEM SCI, V29, P95, DOI 10.1016/j.tibs.2003.12.004
   Junger Martin A, 2003, J Biol, V2, P20, DOI 10.1186/1475-4924-2-20
   Kalogerakis G, 2005, CLIN SCI, V108, P497, DOI 10.1042/CS20040312
   Kalra P, 2022, NEUROCHEM RES, V47, P825, DOI 10.1007/s11064-021-03500-0
   Kang CH, 2013, TOXICOL IN VITRO, V27, P782, DOI 10.1016/j.tiv.2012.12.012
   Kang KX, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/8169981
   Khan H., 2018, INT J PHARM SCI REV
   Khan H, 2022, INFLAMM RES, V71, P277, DOI 10.1007/s00011-022-01546-6
   Khan H, 2022, NEUROCHEM RES, V47, P1125, DOI 10.1007/s11064-021-03521-9
   Khan H, 2021, MOL NEUROBIOL, V58, P3903, DOI 10.1007/s12035-021-02387-w
   Khan H, 2021, PHARMACOL REP, V73, P1240, DOI 10.1007/s43440-021-00258-8
   Landreth G, 2007, CURR ALZHEIMER RES, V4, P159, DOI 10.2174/156720507780362092
   Li J, 2015, MOL NEUROBIOL, V51, P1024, DOI 10.1007/s12035-014-8762-1
   Li YZ, 2010, J NEUROCHEM, V113, P1621, DOI 10.1111/j.1471-4159.2010.06731.x
   Liu JL, 2020, NEUROCHEM INT, V133, DOI 10.1016/j.neuint.2019.104624
   Liu W, 2017, NAT COMMUN, V8, DOI [10.1038/s41467-017-00664-8, 10.1038/s41467-017-00778-z]
   Ma T, 2013, NAT NEUROSCI, V16, P1299, DOI 10.1038/nn.3486
   Manolopoulos KN, 2010, MOL PSYCHIATR, V15, P1046, DOI 10.1038/mp.2010.17
   Martin B, 2006, AGEING RES REV, V5, P332, DOI 10.1016/j.arr.2006.04.002
   Martin B, 2009, DIABETES, V58, P318, DOI 10.2337/db08-0799
   Marwarha G, 2019, MOL NEUROBIOL, V56, P5256, DOI 10.1007/s12035-018-1451-8
   Matsuzaki K, 2022, NUTRIENTS, V14, DOI 10.3390/nu14091847
   Micaroni M, 2010, CURR MOL MED, V10, P763, DOI 10.2174/156652410793384204
   Moll Lorna, 2012, Curr Gerontol Geriatr Res, V2012, P384094, DOI 10.1155/2012/384094
   Nagashima T, 2010, MOL PHARMACOL, V78, P961, DOI 10.1124/mol.110.065714
   O'Brien RJ, 2011, ANNU REV NEUROSCI, V34, P185, DOI 10.1146/annurev-neuro-061010-113613
   Pan X, 2017, SCI REP-UK, V7, DOI 10.1038/srep44597
   Phiel CJ, 2003, NATURE, V423, P435, DOI 10.1038/nature01640
   Picone P, 2020, EUR J NEUROSCI, V52, P3944, DOI 10.1111/ejn.14758
   Ponugoti B, 2012, EXP DIABETES RES, DOI 10.1155/2012/939751
   Prabhakar NK, 2022, INT IMMUNOPHARMACOL, V108, DOI 10.1016/j.intimp.2022.108902
   Pradhan R, 2020, MECH AGEING DEV, V190, DOI 10.1016/j.mad.2020.111290
   Puig O, 2003, GENE DEV, V17, P2006, DOI 10.1101/gad.1098703
   Qin WP, 2008, ANN NY ACAD SCI, V1147, P335, DOI 10.1196/annals.1427.024
   Rajendran L, 2012, TRAFFIC, V13, P759, DOI 10.1111/j.1600-0854.2012.01332.x
   Saklani P, 2022, MOL BIOL REP, V49, P10101, DOI 10.1007/s11033-022-07594-9
   Salih DAM, 2008, CURR OPIN CELL BIOL, V20, P126, DOI 10.1016/j.ceb.2008.02.005
   Salminen A, 2009, J NEUROINFLAMM, V6, DOI 10.1186/1742-2094-6-41
   Sanphui P, 2013, CELL DEATH DIS, V4, DOI 10.1038/cddis.2013.148
   Scarmeas N, 2009, JAMA-J AM MED ASSOC, V302, P627, DOI 10.1001/jama.2009.1144
   Schoultz I, 2011, INFLAMM BOWEL DIS, V17, P2008, DOI 10.1002/ibd.21556
   Seaman MNJ, 2008, CELL MOL LIFE SCI, V65, P2842, DOI 10.1007/s00018-008-8354-1
   Shi C, 2016, J CELL SCI, V129, P1815, DOI 10.1242/jcs.185009
   Small SA, 2005, ANN NEUROL, V58, P909, DOI 10.1002/ana.20667
   Smith WW, 2005, J CELL BIOL, V169, P331, DOI 10.1083/jcb.200410041
   Sullivan CP, 2011, NEUROBIOL DIS, V43, P338, DOI 10.1016/j.nbd.2011.04.002
   Tan JG, 2012, J NEUROCHEM, V120, P869, DOI 10.1111/j.1471-4159.2011.07623.x
   Tavassoly O, 2020, MOL PHARMACOL, V98, P13, DOI 10.1124/mol.120.119909
   Valenti L, 2008, DIABETES, V57, P1355, DOI 10.2337/db07-0714
   van der Vos KE, 2011, ANTIOXID REDOX SIGN, V14, P579, DOI 10.1089/ars.2010.3419
   Wang L, 2019, LIPIDS HEALTH DIS, V18, DOI 10.1186/s12944-019-1132-2
   Wang S, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms11023
   Wang X, 2014, CELL DEATH DIS, V5, DOI 10.1038/cddis.2014.196
   Wang YP, 2020, AGING-US, V12, P20862, DOI 10.18632/aging.104104
   Watson GS, 2005, AM J GERIAT PSYCHIAT, V13, P950, DOI 10.1176/appi.ajgp.13.11.950
   Wellen KE, 2010, MOL CELL, V40, P323, DOI 10.1016/j.molcel.2010.10.004
   Wong HKA, 2013, HUM MOL GENET, V22, P3077, DOI 10.1093/hmg/ddt164
   Xia WM, 2009, ARCH NEUROL-CHICAGO, V66, P190, DOI 10.1001/archneurol.2008.565
   Yamaguchi H, 1996, ACTA NEUROPATHOL, V92, P232, DOI 10.1007/s004010050513
   Yan X, 2020, FRONT NEUROSCI-SWITZ, V14, DOI 10.3389/fnins.2020.530219
   Zemva J, 2012, EXP CLIN ENDOCR DIAB, V120, P340, DOI 10.1055/s-0031-1297970
   Zhao Y, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/316523
NR 97
TC 4
Z9 4
U1 3
U2 3
PU BENTHAM SCIENCE PUBL
PI BUSUM
PA PO BOX 294, BUSUM, 1400 AG, NETHERLANDS
SN 1871-5273
EI 1996-3181
J9 CNS NEUROL DISORD-DR
JI CNS Neurol. Disord.-Drug Targets
PY 2025
VL 24
IS 3
BP 196
EP 207
DI 10.2174/0118715273321002240919102841
EA OCT 2024
PG 12
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA S3J4C
UT WOS:001345435500001
PM 39473249
DA 2025-06-11
ER

PT J
AU Alagiakrishnan, K
   Halverson, T
AF Alagiakrishnan, Kannayiram
   Halverson, Tyler
TI Role of Peripheral and Central Insulin Resistance in Neuropsychiatric
   Disorders
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE brain insulin resistance; dementia; depression; exercise; antidiabetic
   drugs
ID BLOOD-BRAIN-BARRIER; COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; METABOLIC
   SYNDROME; GLUCOSE-METABOLISM; INTRANASAL INSULIN; SIGNALING PATHWAYS;
   DIABETIC-PATIENTS; DOUBLE-BLIND; SENSITIVITY
AB Insulin acts on different organs, including the brain, which helps it regulate energy metabolism. Insulin signaling plays an important role in the function of different cell types. In this review, we have summarized the key roles of insulin and insulin receptors in healthy brains and in different brain disorders. Insulin signaling, as well as insulin resistance (IR), is a major contributor in the regulation of mood, behavior, and cognition. Recent evidence showed that both peripheral and central insulin resistance play a role in the pathophysiology, clinical presentation, and management of neuropsychiatric disorders like Cognitive Impairment/Dementia, Depression, and Schizophrenia. Many human studies point out Insulin Resistance/Metabolic Syndrome can increase the risk of dementia especially Alzheimer's dementia (AD). IR has been shown to play a role in AD development but also in its progression. This review article discusses the pathophysiological pathways and mechanisms of insulin resistance in major neuropsychiatric disorders. The extent of insulin resistance can be quantified using IR biomarkers like insulin levels, HOMA-IR index, and Triglyceride glucose-body mass index (TyG-BMI) levels. IR has been shown to precede neurodegeneration. Human trials showed current treatment with certain antidiabetic drugs, as well as life style management, like weight loss and exercise for IR, have shown promise in the management of cognitive/neuropsychiatric disorders. This may pave the pathway to the development of new therapeutic approaches to these challenging disorders of dementia and psychiatric diseases. Recent clinical trials are showing some encouraging evidence for these pharmacological and nonpharmacological approaches for IR in psychiatric and cognitive disorders, even though more research is needed to apply this evidence into clinical practice. Early identification and management of IR may help as a strategy to potentially alter neuropsychiatric disorders onset as well as its progression
C1 [Alagiakrishnan, Kannayiram] Univ Alberta, Dept Med, Edmonton, AB T6G 2R3, Canada.
   [Halverson, Tyler] Univ Toronto, Dept Psychiat, Toronto, ON M5T 1R8, Canada.
C3 University of Alberta; University of Toronto
RP Alagiakrishnan, K (corresponding author), Univ Alberta, Dept Med, Edmonton, AB T6G 2R3, Canada.
EM kalagiakri@aol.com; halverso@ualberta.ca
CR Abbasi F, 2023, PSYCHONEUROENDOCRINO, V147, DOI 10.1016/j.psyneuen.2022.105944
   Abdalla MMI, 2024, WORLD J DIABETES, V15, DOI 10.4239/wjd.v15.i7.1430
   Agarwal SM, 2021, TRANSL PSYCHIAT, V11, DOI 10.1038/s41398-021-01338-2
   Ahmad RMA, 2022, DIABETES METAB SYND, V16, DOI 10.1016/j.dsx.2022.102468
   Akintola AA, 2015, FRONT ENDOCRINOL, V6, DOI 10.3389/fendo.2015.00013
   Al Jobori H, 2018, J CLIN ENDOCR METAB, V103, P1402, DOI 10.1210/jc.2017-01838
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Amaravadi SK, 2024, PLOS ONE, V19, DOI 10.1371/journal.pone.0302831
   Arnold SE, 2018, NAT REV NEUROL, V14, P168, DOI 10.1038/nrneurol.2017.185
   Artese A, 2019, AM J LIFESTYLE MED, V13, P602, DOI 10.1177/1559827617726516
   ATTVALL S, 1993, J INTERN MED, V233, P327, DOI 10.1111/j.1365-2796.1993.tb00680.x
   Avgerinos KI, 2018, J NEUROL, V265, P1497, DOI 10.1007/s00415-018-8768-0
   Banks WA, 2004, EUR J PHARMACOL, V490, P5, DOI 10.1016/j.ejphar.2004.02.040
   Banks WA, 1997, PEPTIDES, V18, P1423, DOI 10.1016/S0196-9781(97)00231-3
   Bauermeister SD, 2023, BMJ MENTAL HEALTH, V26, DOI 10.1136/bmjment-2023-300665
   Bellelli G, 2009, J AM GERIATR SOC, V57, P178, DOI 10.1111/j.1532-5415.2009.02067.x
   Bergman BC, 2012, DIABETES, V61, P3156, DOI 10.2337/db12-0418
   Bermudez Valmore, 2016, Adv Prev Med, V2016, P9405105, DOI 10.1155/2016/9405105
   Blázquez E, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00161
   Born J, 2002, NAT NEUROSCI, V5, P514, DOI 10.1038/nn849
   Bromander S, 2010, J NEURAL TRANSM, V117, P1167, DOI 10.1007/s00702-010-0456-x
   Cai WK, 2018, J CLIN INVEST, V128, P2914, DOI 10.1172/JCI99366
   Cai WK, 2017, NAT COMMUN, V8, DOI [10.1038/ncomms14892, 10.1038/s41467-017-00417-7]
   Calkin CV, 2022, J CLIN PSYCHIAT, V83, DOI 10.4088/JCP.21m14022
   Cefalu WT, 2001, EXP BIOL MED, V226, P13, DOI 10.1177/153537020122600103
   Cha DS, 2017, J AFFECT DISORDERS, V210, P57, DOI 10.1016/j.jad.2016.12.006
   Chen H, 2005, DIABETES, V54, P1914, DOI 10.2337/diabetes.54.7.1914
   Chen WQ, 2022, TRENDS NEUROSCI, V45, P384, DOI 10.1016/j.tins.2022.03.001
   Csajbók ÉA, 2016, DIABETOLOGIA, V59, P1609, DOI 10.1007/s00125-016-3996-2
   Cukierman-Yaffe T, 2020, LANCET NEUROL, V19, P582, DOI 10.1016/S1474-4422(20)30173-3
   De Felice FG, 2014, ALZHEIMERS DEMENT, V10, pS26, DOI 10.1016/j.jalz.2013.12.004
   DORN A, 1983, J HIRNFORSCH, V24, P495
   Dyer AH, 2016, NEUROSCIENCE, V325, P89, DOI 10.1016/j.neuroscience.2016.03.056
   Einhorn Daniel, 2003, Endocr Pract, V9, P237
   Ekblad LL, 2018, NEUROLOGY, V90, pE1150, DOI 10.1212/WNL.0000000000005214
   Eliasson B, 1996, CIRCULATION, V94, P878, DOI 10.1161/01.CIR.94.5.878
   ELIASSON B, 1994, ARTERIOSCLER THROMB, V14, P1946, DOI 10.1161/01.ATV.14.12.1946
   Eliasson B, 1997, EUR J CLIN INVEST, V27, P450, DOI 10.1046/j.1365-2362.1997.1330680.x
   Fadel JR, 2016, CURR OPIN BEHAV SCI, V9, P47, DOI 10.1016/j.cobeha.2015.12.004
   Fava A, 2017, METAB BRAIN DIS, V32, P799, DOI 10.1007/s11011-017-9977-4
   Fazio S, 2024, BIOMEDICINES, V12, DOI 10.3390/biomedicines12071417
   Fedewa MV, 2014, PEDIATRICS, V133, pE163, DOI 10.1542/peds.2013-2718
   Fernandes BS, 2022, NEUROSCI BIOBEHAV R, V139, DOI 10.1016/j.neubiorev.2022.104758
   Fernandez AM, 2012, NAT REV NEUROSCI, V13, P225, DOI 10.1038/nrn3209
   FERRANNINI E, 1993, HORM RES, V39, P107, DOI 10.1159/000182795
   Folch J, 2019, FRONT AGING NEUROSCI, V11, DOI 10.3389/fnagi.2019.00236
   Galimberti D, 2017, EXPERT OPIN INV DRUG, V26, P97, DOI 10.1080/13543784.2017.1265504
   Giannarelli R., 2003, Diabetes & Metabolism, V29, p6S28
   Gold M, 2010, DEMENT GERIATR COGN, V30, P131, DOI 10.1159/000318845
   Gralle M, 2017, J NEUROCHEM, V140, P359, DOI 10.1111/jnc.13909
   Gruber J, 2023, NEUROSCI BIOBEHAV R, V149, DOI 10.1016/j.neubiorev.2023.105179
   Guo SD, 2014, J ENDOCRINOL, V220, pT1, DOI 10.1530/JOE-13-0327
   Guo Shaodong, 2013, Drug Discov Today Dis Mech, V10, pe27
   Guo ZY, 2017, SCI REP-UK, V7, DOI 10.1038/srep45971
   Gutt M, 2000, DIABETES RES CLIN PR, V47, P177, DOI 10.1016/S0168-8227(99)00116-3
   Hattori S, 2020, DIABETOL METAB SYNDR, V12, DOI 10.1186/s13098-020-00533-3
   Hawley JA, 2008, ACTA PHYSIOL, V192, P127, DOI 10.1111/j.1748-1716.2007.01783.x
   Hawley JA, 2004, DIABETES-METAB RES, V20, P383, DOI 10.1002/dmrr.505
   Heni M, 2014, ACTA DIABETOL, V51, P679, DOI 10.1007/s00592-013-0546-y
   Hong S, 2021, ALZHEIMERS RES THER, V13, DOI 10.1186/s13195-020-00758-4
   Hooshmand B, 2019, AM J MED, V132, P367, DOI 10.1016/j.amjmed.2018.11.013
   Hoyer S, 2004, EUR J PHARMACOL, V490, P115, DOI 10.1016/j.ejphar.2004.02.049
   Husain MA, 2021, FRONT NEUROSCI-SWITZ, V15, DOI 10.3389/fnins.2021.630502
   Ishibashi K, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0181400
   Isik AT, 2017, DIABETES RES CLIN PR, V123, P192, DOI 10.1016/j.diabres.2016.12.010
   Jin M, 2023, MEDICINE, V102, DOI 10.1097/MD.0000000000034058
   Vasques ACJ, 2011, DIABETES RES CLIN PR, V93, pE98, DOI 10.1016/j.diabres.2011.05.030
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   Kang B, 2017, INT J OBESITY, V41, P789, DOI 10.1038/ijo.2017.14
   Kapogiannis D, 2024, CELL METAB, V36, DOI 10.1016/j.cmet.2024.05.017
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   Kellar D, 2021, JPAD-J PREV ALZHEIM, V8, P240, DOI 10.14283/jpad.2021.14
   Khakh BS, 2019, ANNU REV NEUROSCI, V42, P187, DOI 10.1146/annurev-neuro-070918-050443
   Kheirollahi A, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-01410-8
   King GL, 2016, DIABETES, V65, P1462, DOI 10.2337/db16-0152
   Kleinridders A, 2014, DIABETES, V63, P2232, DOI 10.2337/db14-0568
   Kong SH, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-017-18998-0
   Kothari V, 2017, BBA-MOL BASIS DIS, V1863, P499, DOI 10.1016/j.bbadis.2016.10.006
   Kraemer FB, 2014, DIABETES CARE, V37, P1178, DOI 10.2337/dc13-2668
   Kullmann S, 2022, JCI INSIGHT, V7, DOI 10.1172/jci.insight.161498
   Kumar AS, 2019, ANN PHYS REHABIL MED, V62, P98, DOI 10.1016/j.rehab.2018.11.001
   Lapinska L, 2022, POL ARCH INTERN MED, V132, DOI 10.20452/pamw.16261
   Laws SM, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-09577-4
   Lebovitz HE, 2001, EXP CLIN ENDOCR DIAB, V109, pS135, DOI 10.1055/s-2001-18576
   Leclerc M, 2023, BRAIN, V146, P75, DOI 10.1093/brain/awac309
   Lee YS, 2016, MEDIAT INFLAMM, V2016, DOI 10.1155/2016/3094642
   Li MW, 2022, SIGNAL TRANSDUCT TAR, V7, DOI 10.1038/s41392-022-01073-0
   Liu JJ, 2023, FRONT PSYCHIATRY, V14, DOI 10.3389/fpsyt.2023.1231524
   Liu YQ, 2024, J AFFECT DISORDERS, V359, P70, DOI 10.1016/j.jad.2024.05.049
   Luchsinger JA, 2004, NEUROLOGY, V63, P1187, DOI 10.1212/01.WNL.0000140292.04932.87
   Malin SK, 2022, J APPL PHYSIOL, V133, P1368, DOI 10.1152/japplphysiol.00375.2022
   Martin B, 2006, AGEING RES REV, V5, P332, DOI 10.1016/j.arr.2006.04.002
   Matsuda M, 1999, DIABETES CARE, V22, P1462, DOI 10.2337/diacare.22.9.1462
   Matsuzaki T, 2010, NEUROLOGY, V75, P764, DOI 10.1212/WNL.0b013e3181eee25f
   McAuley KA, 2001, DIABETES CARE, V24, P460, DOI 10.2337/diacare.24.3.460
   Mendrick DL, 2018, TOXICOL SCI, V162, P36, DOI 10.1093/toxsci/kfx233
   Milstein JL, 2021, MOL METAB, V52, DOI 10.1016/j.molmet.2021.101234
   Nam KW, 2020, CARDIOVASC DIABETOL, V19, DOI 10.1186/s12933-020-01031-6
   Neergaard JS, 2017, DIABETES, V66, P1957, DOI 10.2337/db16-1444
   Nelson TJ, 2008, EUR J PHARMACOL, V585, P76, DOI 10.1016/j.ejphar.2008.01.051
   Ng TP, 2014, J ALZHEIMERS DIS, V41, P61, DOI 10.3233/JAD-131901
   Pani G, 2015, SEMIN CELL DEV BIOL, V40, P106, DOI 10.1016/j.semcdb.2015.03.004
   Park SE, 2015, CRIT REV CL LAB SCI, V52, P180, DOI 10.3109/10408363.2015.1023429
   Pearson S, 2010, DIABETES CARE, V33, P1128, DOI 10.2337/dc09-1940
   Peila R, 2004, NEUROLOGY, V63, P228, DOI 10.1212/01.WNL.0000129989.28404.9B
   Polidori N, 2022, HORM RES PAEDIAT, V95, P149, DOI 10.1159/000521515
   Possidente C, 2023, NEUROSCI BIOBEHAV R, V152, DOI 10.1016/j.neubiorev.2023.105298
   Reckziegel MB, 2022, ARCH ENDOCRIN METAB, V67, P153, DOI 10.20945/2359-3997000000506
   Reiman EM, 2005, P NATL ACAD SCI USA, V102, P8299, DOI 10.1073/pnas.0500579102
   Rhea EM, 2024, AGING DIS, V15, P1688, DOI 10.14336/AD.2023.0814
   Rizzo MR, 2014, J GERONTOL A-BIOL, V69, P1122, DOI 10.1093/gerona/glu032
   Rönnemaa E, 2009, DIABETOLOGIA, V52, P1504, DOI 10.1007/s00125-009-1393-9
   Ruegsegger GN, 2019, JCI INSIGHT, V4, DOI 10.1172/jci.insight.130681
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Salkovic-Petrisic M, 2009, J ALZHEIMERS DIS, V18, P729, DOI 10.3233/JAD-2009-1184
   Samuel VT, 2016, J CLIN INVEST, V126, P12, DOI 10.1172/JCI77812
   Sánchez-García A, 2020, INT J ENDOCRINOL, V2020, DOI 10.1155/2020/4678526
   Sangwung P, 2020, ENDOCRINOLOGY, V161, DOI 10.1210/endocr/bqaa017
   Schenk S, 2009, J PHYSIOL-LONDON, V587, P4949, DOI 10.1113/jphysiol.2009.175489
   Scherer T, 2021, NAT REV ENDOCRINOL, V17, P468, DOI 10.1038/s41574-021-00498-x
   Schrijvers EMC, 2010, NEUROLOGY, V75, P1982, DOI 10.1212/WNL.0b013e3181ffe4f6
   Shao TN, 2023, TRANSL PSYCHIAT, V13, DOI 10.1038/s41398-023-02616-x
   Shen JW, 2024, FRONT PHYSIOL, V15, DOI 10.3389/fphys.2024.1337442
   Sherzai AZ, 2018, J NEUROL SCI, V388, P97, DOI 10.1016/j.jns.2017.11.031
   Shih KC, 2010, METABOLISM, V59, P144, DOI 10.1016/j.metabol.2009.06.035
   Sluggett JK, 2020, J CLIN ENDOCR METAB, V105, DOI 10.1210/clinem/dgz234
   Smith PJ, 2019, J ALZHEIMERS DIS, V71, P921, DOI 10.3233/JAD-190569
   Starks EJ, 2015, J ALZHEIMERS DIS, V46, P525, DOI 10.3233/JAD-150072
   Suarez EC, 2017, INT J BEHAV MED, V24, P927, DOI 10.1007/s12529-017-9652-5
   Talbot K, 2012, J CLIN INVEST, V122, P1316, DOI 10.1172/JCI59903
   Thankappan S, 2018, ASIAN J PSYCHIATR, V38, P33, DOI 10.1016/j.ajp.2018.10.026
   Nguyen TT, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21093165
   Tomasik J, 2019, JAMA PSYCHIAT, V76, P864, DOI 10.1001/jamapsychiatry.2019.0304
   van der Heide LP, 2006, PROG NEUROBIOL, V79, P205, DOI 10.1016/j.pneurobio.2006.06.003
   Watson KT, 2021, JAMA PSYCHIAT, V78, P439, DOI 10.1001/jamapsychiatry.2020.3669
   White MF, 2003, SCIENCE, V302, P1710, DOI 10.1126/science.1092952
   Wu CY, 2023, DIABETES CARE, V46, P297, DOI 10.2337/dc22-1705
   Wu S, 2023, PLOS ONE, V18, DOI 10.1371/journal.pone.0286887
   Yan FF, 2022, CARDIOVASC DIABETOL, V21, DOI 10.1186/s12933-022-01664-9
   Young SE, 2006, DIABETES CARE, V29, P2688, DOI 10.2337/dc06-0915
   Zhang J, 2024, J CLIN MED, V13, DOI 10.3390/jcm13041172
   Zheng L, 2023, NUTR METAB CARDIOVAS, V33, P507, DOI 10.1016/j.numecd.2022.11.015
   Zhuo CJ, 2024, CNS DRUGS, V38, P33, DOI 10.1007/s40263-023-01057-w
NR 144
TC 1
Z9 1
U1 5
U2 6
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD NOV
PY 2024
VL 13
IS 21
AR 6607
DI 10.3390/jcm13216607
PG 19
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA L5Y1P
UT WOS:001351463100001
PM 39518747
OA gold
DA 2025-06-11
ER

PT J
AU Roskar, S
   Zorko, M
   Bucik, V
   Marusic, A
AF Roskar, Saska
   Zorko, Maja
   Bucik, Valentin
   Marusic, Andrej
TI Problem solving for depressed suicide attempters and depressed
   individuals without suicide attempt
SO PSYCHIATRIA DANUBINA
LA English
DT Article
DE metabolic syndrome; schizophrenia; schizoaffective disorder; bipolar
   disorder; major depression; post-traumatic stress syndrome
ID AUTOBIOGRAPHICAL MEMORY; MAJOR DEPRESSION; HOPELESSNESS; DEFICITS;
   IDEATION; REEXAMINATION; BEHAVIOR; FUTURE; RISK
AB Background. Next to feelings of hopelessness, certain cognitive features such as problem solving deficiency, attentional bias and reduced future positive thinking are involved in the development and maintenance of suicidal beahviour. The aim of this study was to examine feelings of hopelessness and problem solving ability in depressed suicide attempters and depressed individuals without a suicide attempt and to see whether these features change over time.
   Method. Three groups of participants, depressed suicide attempters (N=23), psychiatric control group (N=27) and healthy volunteers (N=27) completed measures of hopelessness and executive planning and problem solving abilities. The two clinical groups completed all measures shortly after admission and then again 7 weeks later whereas the non-clinical control group completed meassures at baseline only.
   Results. Both clinical groups displayed a higher level of hopelessness and poorer problem solving ability when compared to non-clinical volunteers. However, no differences were found between the two clinical groups. In neither of the clinical groups was improvement in problem solving ability between baseline and retesting observed despite the lowering of feelings of hopelessness.
   Limitations. The diagnoses in the psychiatric controls group were only obtained by the psychiatrist and not checked by further documentation or questionnaires. Furthermore we did not control for personality traits which might influence cognitive functioning.
   Conclusion. Since feelings of hopelessness decreased over time and problem solving ability nontheless remained stable it is important that treatment not only focuses on mood improvement of depressed suicidal and depressed non-suicidal individuals but also on teaching problem solving techniques.
C1 [Bucik, Valentin] Univ Ljubljana, Dept Psychol, Ljubljana 61000, Slovenia.
   [Marusic, Andrej] Univ Primorska, PINT, Primorska, Slovenia.
C3 University of Ljubljana; University of Primorska
RP Roskar, S (corresponding author), IVZ RS, Trubarjeva 2, Ljubljana 1000, Slovenia.
EM saska.roskar@ivz-rs.si
RI Roskar, Saska/MGA-5097-2025
CR BECK AT, 1974, J CONSULT CLIN PSYCH, V42, P861, DOI 10.1037/h0037562
   Biggam FH, 1999, ARCH SUICIDE RES, V5, P27, DOI 10.1080/13811119908258313
   Biringer E, 2005, EUR ARCH PSY CLIN N, V255, P373, DOI 10.1007/s00406-005-0577-7
   Bostwick JM, 2000, AM J PSYCHIAT, V157, P1925, DOI 10.1176/appi.ajp.157.12.1925
   Conaghan S, 2002, BRIT J CLIN PSYCHOL, V41, P233, DOI 10.1348/014466502760379208
   CULBERSTON CW, 2001, TOWER LONDON
   EVANS J, 1992, PSYCHOL MED, V22, P399, DOI 10.1017/S0033291700030348
   Kaviani H, 2005, J PSYCHOPATHOL BEHAV, V27, P39, DOI 10.1007/s10862-005-3264-0
   Keilp JG, 2001, AM J PSYCHIAT, V158, P735, DOI 10.1176/appi.ajp.158.5.735
   MACLEOD AK, 2004, MOOD DISORDERS HDB S
   Malone KM, 2000, AM J PSYCHIAT, V157, P1084, DOI 10.1176/appi.ajp.157.7.1084
   MALONE KM, 1995, J AFFECT DISORDERS, V34, P173, DOI 10.1016/0165-0327(95)00015-F
   Mann JJ, 1999, AM J PSYCHIAT, V156, P181
   Marzuk PM, 2005, ACTA PSYCHIAT SCAND, V112, P294, DOI 10.1111/j.1600-0447.2005.00585.x
   Pollock LR, 2004, PSYCHOL MED, V34, P163, DOI 10.1017/S0033291703008092
   Pollock LR, 1998, SUICIDE LIFE-THREAT, V28, P375
   Reischies FM, 2000, EUR ARCH PSY CLIN N, V250, P186, DOI 10.1007/s004060070023
   SCHOTTE DE, 1990, J CONSULT CLIN PSYCH, V58, P562, DOI 10.1037/0022-006X.58.5.562
   Sidley G.L., 1997, Behavioural and Cognitive Psychotherapy, V25, P195, DOI DOI 10.1017/S1352465800018397
   VANHEERINGEN C, 2005, PREVENTION TREATMENT
   Williams J., 2001, UNDERSTANDING SUICID, P76
   Williams J.M., 1997, THE CRY OF PAIN
   Williams J.M. G., 2005, PREVENTION TREATMENT, P71, DOI DOI 10.1093/MED/9780198529767.003.0005
   Williams JMG, 2006, J AFFECT DISORDERS, V91, P189, DOI 10.1016/j.jad.2006.01.002
   Williams JMG, 2005, J ABNORM PSYCHOL, V114, P421, DOI 10.1037/0021-843X.114.3.421
   Williams JMG, 1996, MEM COGNITION, V24, P116, DOI 10.3758/BF03197278
   WILLIAMS JMG, 2007, IN PRESS COGNITIVE T
   Young MA, 1996, J ABNORM PSYCHOL, V105, P155, DOI 10.1037/0021-843X.105.2.155
NR 28
TC 17
Z9 22
U1 0
U2 16
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PD DEC
PY 2007
VL 19
IS 4
BP 296
EP 302
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 272HA
UT WOS:000253849300004
PM 18000480
DA 2025-06-11
ER

PT J
AU Zhang, YX
   Zhang, LF
   Li, ZY
   Liu, XY
   He, PK
   Gu, YY
   Liu, LL
   Jin, Y
   Cheng, SB
   Zhou, FH
   Jia, YH
AF Zhang, Yaxin
   Zhang, Lifang
   Li, Zhaoyong
   Liu, Xiaoyu
   He, Peikun
   Gu, Yuyan
   Liu, Linling
   Jin, Yao
   Cheng, Saibo
   Zhou, Fenghua
   Jia, Yuhua
TI Gualou-Xiebai-Banxia-Tang regulates liver-gut axis to ameliorate
   Metabolic Syndrome in HFD-fed mice
SO PHYTOMEDICINE
LA English
DT Article
DE Metabolic syndrome; Gut microbiota; Liver transcriptomics; TCM;
   Gualou-Xiebai-Banxia-Tang decoction
ID LIPID-METABOLISM; OBESITY; MICROBIOME
AB Background: Metabolic syndrome (MetS), characterized by obesity, hyperglycemia, and abnormal blood lipid levels, is the pathological basis of many cardiovascular diseases. Gualou-Xiebai-Banxia-Tang decoction (GT) was first described in the Synopsis of the Golden Chamber, the earliest traditional Chinese medicine (TCM) monograph on diagnosis and treatment of miscellaneous diseases in China. According to TCM precepts, based on its ability to activate yang to release stagnation, activate qi to reduce depression, remove phlegm, and broaden the chest, GT has been used for more than 2,000 years to treat cardiovascular ailments. However, the molecular bases of its therapeutic mechanisms remain unclear.
   Purpose: The aim of this study was to identify lipid- and glucose-related hepatic genes differentially regulated by GT, and to assess GT impact on gut microbiota composition, in mice with high-fat diet (HFD)-induced MetS.
   Study design and methods: ApoE(-/-) mice were fed with an HFD for 24 weeks, with or without concurrent GT supplementation, to induce MetS. At the study's end, body weight, visceral fat weight, blood lipid levels, and insulin sensitivity were measured, and histopathological staining was used to evaluate hepatosteatosis and intestinal barrier integrity. Liver transcriptomics was used for analysis of differentially expressed genes in liver and prediction of relevant regulatory pathways. Hepatic lipid/glucose metabolism-related genes and proteins were detected by RT-qPCR and western blotting. Gut microbial composition was determined by 16S rRNA gene sequencing.
   Results: GT administration reduced MetS-related liver steatosis and weight gain, promoted insulin sensitivity and lipid metabolism, and beneficially modulated gut microbiota composition by decreasing the relative abundance of g_Lachnospiraceae_NK4A136_group and increasing the relative abundance of g_Alistipes. Liver transcriptomics revealed that GT regulated the expression of genes related to lipid and glucose metabolism (Ppar gamma, Igf1, Gpnmb, and Trem2) and of genes encoding chemokines/chemokine receptors (e.g. Cxcl9 and Cx3cr1). Significant, positive correlations were found for Ccr2, Ccl4, Ccr1, and Cx3cr1 and the g_Lachnospiraceae_NK4A136_group, and between Cxcl9, Ccr2, Ccl4, and Cx3cr1 and g_Desulfovibrio. GT treatment downregulated the protein expressions of SCD1 and CX3CR1 and upregulated the expression of PCK1 protein.
   Conclusion: GT supplementation alleviates HFD-induced MetS in mice by improving hepatic lipid and glucose metabolism. The anti-metabolic syndrome effects of GT may be related to the regulation of the gut-liver axis.
C1 [Zhang, Yaxin; Gu, Yuyan] Southern Med Univ, Sch Tradit Chinese Med, Res Lab State Adm Tradit Chinese Med Level 3, Guangzhou, Guangdong, Peoples R China.
   [Zhang, Lifang; Li, Zhaoyong; He, Peikun; Liu, Linling; Jin, Yao; Cheng, Saibo; Zhou, Fenghua; Jia, Yuhua] Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Guangdong, Peoples R China.
   [Liu, Xiaoyu] Southern Med Univ, Pingshan Gen Hosp, Shenzhen Pingshan Dist Med Healthcare Grp, Shenzhen, Guangdong, Peoples R China.
C3 Southern Medical University - China; Southern Medical University -
   China; Southern Medical University - China
RP Cheng, SB; Zhou, FH; Jia, YH (corresponding author), Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Guangdong, Peoples R China.
EM 15013114307@163.com; Wendyzhou515@126.com; yuhuajia_smu@126.com
RI Zhao, Xiaoshan/GPF-7929-2022; Jia, Yu-Hua/D-5097-2012; zhang,
   lifang/ITT-4448-2023; Liu, Xiaoyu/JZD-9005-2024
FU Guangdong natural science foundation project [2021A1515011603,
   2023A1515010451]; Guangdong Basic and Applied Basic Research Fund
   Project [2022A1515111179]; National Natural Science Foundation of China
   [81973802, 82174299]
FX The study was supported by the National Natural Science Foundation of
   China (81973802, 82174299), Guangdong natural science foundation
   <STRONG>project (2021A1515011603, 2023A1515010451) , and Guangdong Basic
   and Applied Basic Research Fund Project (2022A1515111179) .</STRONG>
CR Abenavoli L, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112690
   Ardiansyah, 2010, BRIT J NUTR, V104, P48, DOI 10.1017/S0007114510000255
   Dabke K, 2019, J CLIN INVEST, V129, P4050, DOI 10.1172/JCI129194
   Esparza-Baquer A, 2021, GUT, V70, P1345, DOI 10.1136/gutjnl-2019-319227
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Franza L, 2021, BIOFACTORS, V47, P181, DOI 10.1002/biof.1710
   Fu Y, 2021, CHIN J NAT MEDICINES, V19, P161, DOI 10.1016/S1875-5364(21)60017-1
   García-Fernández M, 2008, ENDOCRINOLOGY, V149, P2433, DOI 10.1210/en.2007-1190
   Gaudry M, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21155321
   Ghafouri A, 2021, PHYTOMEDICINE, V90, DOI 10.1016/j.phymed.2021.153661
   Gong XM, 2019, NAT METAB, V1, P570, DOI 10.1038/s42255-019-0065-4
   Han X, 2018, FOOD FUNCT, V9, P4366, DOI [10.1039/c8fo00978c, 10.1039/C8FO00978C]
   Hartstra AV, 2015, DIABETES CARE, V38, P159, DOI 10.2337/dc14-0769
   Hua YQ, 2021, PHYTOMEDICINE, V81, DOI 10.1016/j.phymed.2020.153412
   Li BL, 2021, LIFE SCI, V269, DOI 10.1016/j.lfs.2020.119008
   Li LH, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms231810465
   Li XD, 2022, PHYTOMEDICINE, V104, DOI 10.1016/j.phymed.2022.154321
   Liao CY, 2023, FRONT IMMUNOL, V14, DOI 10.3389/fimmu.2023.1130184
   Luo MZ, 2021, BIOSCIENCE REP, V41, DOI 10.1042/BSR20204216
   Ni YH, 2022, METABOLISM, V136, DOI 10.1016/j.metabol.2022.155272
   Parsanathan R, 2020, METAB SYNDR RELAT D, V18, P10, DOI 10.1089/met.2019.0073
   Pekgor S, 2019, METAB SYNDR RELAT D, V17, P296, DOI 10.1089/met.2019.0005
   Ren HN, 2019, BMC ENDOCR DISORD, V19, DOI 10.1186/s12902-019-0366-3
   De Ita JR, 2015, J TRANSL MED, V13, DOI 10.1186/s12967-015-0684-9
   Sakurai Y, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22084156
   Rossi JLS, 2022, DIABETES-METAB RES, V38, DOI 10.1002/dmrr.3502
   Su JY, 2022, J BIOENERG BIOMEMBR, V54, P45, DOI 10.1007/s10863-021-09927-y
   Subudhi S, 2022, HEPATOL COMMUN, V6, P77, DOI 10.1002/hep4.1789
   Thingholm LB, 2019, CELL HOST MICROBE, V26, P252, DOI 10.1016/j.chom.2019.07.004
   Wang PX, 2020, CHINESE MED J-PEKING, V133, P808, DOI 10.1097/CM9.0000000000000696
   Xiang Z, 2022, J ETHNOPHARMACOL, V288, DOI 10.1016/j.jep.2022.114994
   Yang G, 2021, METABOLISM, V117, DOI 10.1016/j.metabol.2021.154712
   Ye Q, 2023, NAT COMMUN, V14, DOI 10.1038/s41467-023-37142-3
   Yu X, 2022, FRONT MICROBIOL, V13, DOI 10.3389/fmicb.2022.1052917
   Zhang CH, 2010, ISME J, V4, P232, DOI 10.1038/ismej.2009.112
   Zhang FY, 2022, J ETHNOPHARMACOL, V297, DOI 10.1016/j.jep.2022.115530
   Zhang X, 2021, GUT, V70, P761, DOI 10.1136/gutjnl-2019-319664
   Zhang YX, 2021, AM J CHINESE MED, V49, P1449, DOI 10.1142/S0192415X21500683
NR 38
TC 4
Z9 4
U1 14
U2 27
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD SEP
PY 2024
VL 132
AR 155320
DI 10.1016/j.phymed.2023.155320
EA JUN 2024
PG 13
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA C8E3P
UT WOS:001291642300001
PM 38901285
OA hybrid
DA 2025-06-11
ER

PT J
AU Kamenicky, P
   Houillier, P
   Vantyghem, MC
AF Kamenicky, Peter
   Houillier, Pascal
   Vantyghem, Marie-Christine
TI Chapter 4: Differential diagnosis of primary hyperparathyroidism
SO ANNALES D ENDOCRINOLOGIE
LA English
DT Article
DE Hypercalcemia with low PTH; Hypercalcemia-hypocalciuria; Normo-calcemic
   hyperparathyroidism; Hypophosphatemia; Brown tumor; Osteoarticular pain
ID BONE-RESORPTION; HYPERCALCEMIA; PATIENT; SERIES; GENE
AB The differential diagnosis of primary hyperparathyroidism can be considered clinically, biologically and radiologically. Clinically, primary hyperparathyroidism should be suspected in case of diffuse pain, renal lithiasis, osteoporosis, repeated fracture, cognitive or psychiatric disorder, or disturbance of consciousness. Nevertheless, the differential diagnosis of primary hyperparathyroidism is mainly biological, particularly in atypical forms, which must be differentiated from hypercalcemia with hypocalciuria or non-elevated PTH on the one hand, and from normo-calcemia with elevated PTH, hypophosphatemia or hypercalciuria on the other. Any differential diagnosis must be preceded by an analysis of the factors likely to disturb phospho-calcium parameters: vitamin D deficiency (assay), renal insufficiency (eGFR measurement), malabsorption (inflammatory disease of the digestive tract, celiac disease, bariatric surgery, etc.), insufficient calcium intake (GRIO questionnaire) and iatrogenic causes (diuretics, antiosteoporotic drugs, excessive vitamin D or calcium supplementation, lithium, corticosteroid therapy, phosphorus intake). Once these factors have been eliminated, hypercalcemia with hypocalciuria should suggest a genetic cause. Hypercalcemia with non-elevated PTH may be secondary to neoplasm, hypervitaminosis D (excessive intake, production or catabolism), immobilization or endocrine causes. Elevated PTH values without hypercalcemia must be differentiated from normo-calcemic hyperparathyroidism. High PTH levels are found in PTH-resistant patients, as well as in hypophosphatemic (especially X-linked) or hypercalciuric tubulopathies (certain rare diseases, immobilization, loop diuretics or idiopathic causes favored by a metabolic syndrome). Radiologically, brown tumor must be differentiated primarily from bone metastasis, chondrosarcoma and giant cell tumor. (c) 2025 Published by Elsevier Masson SAS.
C1 [Kamenicky, Peter] Univ Paris Saclay, Serv Endocrinol & Malad Reprod, Ctr Reference Malad Rares Metab Calcium & Phosphat, Hop Bicetre,Assistance Publ Hop Paris,Inserm,Physi, F-94275 Le Kremlin Bicetre, France.
   [Houillier, Pascal] Univ Paris Cite, CNRS Equipe Mixte Rech 8228, Lab Physiol Renale & Tubulopathies, Ctr Rech Cordeliers,Inst Natl Sante & Recherche Me, F-75006 Paris, France.
   [Houillier, Pascal] Hop Europeen Georges Pompidou, Assistance Publ Hop Paris, Serv Physiol, F-75015 Paris, France.
   [Houillier, Pascal] Ctr Reference Malad Rares Calcium & Phosphate, European Reference Network Rare Endocrine Condit E, F-75015 Paris, France.
   [Houillier, Pascal] Univ Paris Cite, Fac Med, F-75006 Paris, France.
   [Vantyghem, Marie-Christine] CHU Lille, Serv Endocrinol Diabetol Metab Nutr, Hop Huriez, 1 Rue Polonovski, F-59037 Lille, France.
   [Vantyghem, Marie-Christine] Univ Lille, Inst Genom European Diabete, Inserm U1190, F-59000 Lille, France.
C3 Universite Paris Saclay; Assistance Publique Hopitaux Paris (APHP);
   Hopital Universitaire Bicetre - APHP; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Universite Paris Cite; Hopital
   Universitaire Saint-Louis - APHP; Hopital Universitaire Antoine-Beclere
   - APHP; Universite Paris Cite; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Sorbonne Universite; Assistance Publique
   Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire
   Europeen Georges-Pompidou - APHP; Hopital Universitaire Saint-Louis -
   APHP; Universite Paris Cite; Universite de Lille; CHU Lille; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite de
   Lille
RP Vantyghem, MC (corresponding author), CHU Lille, Endocrinol Diabetol Metab & Nutr, F-59000 Lille, France.
EM mc-vantyghem@chru-lille.fr
RI Kamenicky, Peter/S-4554-2018; VANTYGHEM, Marie/T-8613-2019
OI KAMENICKY, Peter/0000-0002-1994-4226
CR Abu-Abaa M, 2022, CUREUS J MED SCIENCE, V14, DOI 10.7759/cureus.28424
   Ajwah I, 2023, CUREUS J MED SCIENCE, V15, DOI 10.7759/cureus.35206
   Almaden Y, 1998, J AM SOC NEPHROL, V9, P1845
   Arumugam GP, 2006, J BONE MINER METAB, V24, P243, DOI 10.1007/s00774-005-0678-4
   Baugh KA, 2024, SURGERY, V175, P166, DOI 10.1016/j.surg.2023.06.056
   Bennin D, 2024, JBMR PLUS, V8, DOI 10.1093/jbmrpl/ziae012
   Cailleux A, 2015, CLIN ENDOCRINOL, V82, P663, DOI 10.1111/cen.12729
   Chen K, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000006017
   de Beur SMJ, 2023, J INTERN MED, V293, P309, DOI 10.1111/joim.13593
   Donovan PJ, 2015, J CLIN ENDOCR METAB, V100, P2024, DOI 10.1210/jc.2014-4250
   English KA, 2024, HORM-INT J ENDOCRINO, V23, P3, DOI 10.1007/s42000-023-00508-9
   Fields T, 2023, J SURG RES, V288, P202, DOI 10.1016/j.jss.2023.03.001
   Florimonte L, 2016, CLIN NUCL MED, V41, P394, DOI 10.1097/RLU.0000000000001113
   FRANCIS F, 1995, NAT GENET, V11, P130, DOI 10.1038/ng1095-130
   Gild ML, 2018, J CLIN ENDOCR METAB, V103, P3119, DOI 10.1210/jc.2018-01074
   Gonnelli S, 2024, OSTEOPOROSIS INT, V35, P195, DOI 10.1007/s00198-023-06878-5
   Gupta Vishal, 2018, BMJ Case Rep, V2018, DOI 10.1136/bcr-2018-224513
   Haissaguerre M, 2023, EUR J ENDOCRINOL, V188, pK11, DOI 10.1093/ejendo/lvad025
   Halimi C, 2024, J CLIN ENDOCR METAB, V109, P2553, DOI 10.1210/clinem/dgae162
   Hernández-Frías O, 2019, PEDIATR NEPHROL, V34, P1077, DOI 10.1007/s00467-018-4180-3
   iPPSD, PTH/PTHrP signaling inactivation pathologies (formerly pseu- dohypoparathyroidism and related diseases)
   Jin Joon, 2017, J Bone Metab, V24, P249, DOI 10.11005/jbm.2017.24.4.249
   Kamenicky P, 2024, LANCET, V404, P887, DOI 10.1016/S0140-6736(24)01305-9
   Kamenicky P, 2012, J CLIN ENDOCR METAB, V97, P2124, DOI 10.1210/jc.2011-3188
   Kang SJ, 2019, ANN PEDIATR ENDOCRIN, V24, P64, DOI 10.6065/apem.2019.24.1.64
   Karimifar Mozhgan, 2018, Adv Biomed Res, V7, P92, DOI 10.4103/abr.abr_160_17
   Kaufmann M, 2021, J BONE MINER RES, V36, P1340, DOI 10.1002/jbmr.4306
   Kaur K, 2022, BMJ CASE REP, V15, DOI 10.1136/bcr-2022-251454
   Khan MM, 2022, CUREUS J MED SCIENCE, V14, DOI 10.7759/cureus.28329
   Kim BJ, 2017, J CLIN ENDOCR METAB, V102, P2711, DOI 10.1210/jc.2017-00169
   Lanske B, 1999, J CLIN INVEST, V104, P399, DOI 10.1172/JCI6629
   Lebel A, 2024, EUR J ENDOCRINOL, V190, P347, DOI 10.1093/ejendo/lvae049
   Lecoq AL, 2021, ENDOCRIN METAB CLIN, V50, P743, DOI 10.1016/j.ecl.2021.08.001
   Lecoq AL, 2020, J BONE MINER RES, V35, P1263, DOI 10.1002/jbmr.3992
   Lecoq AL, 2020, METABOLISM, V103, DOI 10.1016/j.metabol.2019.154049
   Lemaitre M, 2023, ANN ENDOCRINOL-PARIS, V84, P758, DOI 10.1016/j.ando.2023.05.009
   Liu Jannel, 2023, JCEM Case Rep, V1, pluad071, DOI 10.1210/jcemcr/luad071
   Liu JF, 2017, MOL CLIN ONCOL, V6, P258, DOI 10.3892/mco.2017.1127
   Loyer C, 2016, ANN ENDOCRINOL-PARIS, V77, P615, DOI 10.1016/j.ando.2016.03.002
   Majety P, 2022, ENDOCR PRACT, V28, P1062, DOI 10.1016/j.eprac.2022.07.008
   Makita N, 2022, JCI INSIGHT, V7, DOI 10.1172/jci.insight.156742
   Mannstadt M, 2012, J CLIN ENDOCR METAB, V97, pE1978, DOI 10.1210/jc.2012-1279
   Mantovani G, 2020, HORM RES PAEDIAT, V93, P182, DOI 10.1159/000508985
   Mantovani G, 2018, NAT REV ENDOCRINOL, V14, P476, DOI 10.1038/s41574-018-0042-0
   MARX SJ, 1978, AM J MED, V65, P235, DOI 10.1016/0002-9343(78)90814-8
   Medarov BI, 2009, MAYO CLIN PROC, V84, P261, DOI 10.4065/84.3.261
   Mehta K, 2024, BMJ CASE REP, V17, DOI 10.1136/bcr-2023-256126
   Mifsud S, 2022, BRIT J HOSP MED, V83, DOI 10.12968/hmed.2021.0624
   Mohan Sneha, 2024, JCEM Case Rep, V2, pluae022, DOI 10.1210/jcemcr/luae022
   Nachtigall LB, 2020, J CLIN ENDOCR METAB, V105, pE2271, DOI 10.1210/clinem/dgaa142
   Nampoothiri S, 2016, J CLIN ENDOCR METAB, V101, P4283, DOI 10.1210/jc.2016-2054
   Pereda A, 2021, EUR J ENDOCRINOL, V184, P311, DOI 10.1530/EJE-20-0625
   Piccoli GB, 2014, KIDNEY INT, V86, P450, DOI 10.1038/ki.2013.380
   PORTER RH, 1978, NEW ENGL J MED, V298, P577, DOI 10.1056/NEJM197803162981101
   Pretet V, 2023, CLIN NUCL MED, V48, P1059, DOI 10.1097/RLU.0000000000004883
   Ragate DC, 2024, J BONE MINER METAB, V42, P155, DOI 10.1007/s00774-023-01490-3
   Rossi B, 2014, SKELETAL RADIOL, V43, P693, DOI 10.1007/s00256-013-1770-9
   Saini V, 2022, INDIAN J OTOLARYNGOL, V74, P5319, DOI 10.1007/s12070-020-02304-y
   Saito H, 2018, J CLIN ENDOCR METAB, V103, P2660, DOI 10.1210/jc.2018-00332
   Shah Reshma, 2012, Pituitary, V15 Suppl 1, pS17, DOI 10.1007/s11102-010-0286-8
   Shi SM, 2021, BMC ENDOCR DISORD, V21, DOI 10.1186/s12902-021-00756-z
   Silva Eugenia, 2022, Cureus, V14, pe31757, DOI 10.7759/cureus.31757
   Sipos B, 2023, ENDOCR-RELAT CANCER, V30, DOI 10.1530/ERC-23-0032
   Tostivint IN, 2022, UROLITHIASIS, V50, P577, DOI 10.1007/s00240-022-01355-w
   Trombetti A, 2022, NAT REV ENDOCRINOL, V18, P366, DOI 10.1038/s41574-022-00662-x
   van den Berg G, 2024, NEPHRON, V148, P569, DOI 10.1159/000538037
   Vantyghem MC, 2023, ANN ENDOCRINOL-PARIS, V84, P391, DOI 10.1016/j.ando.2023.03.004
   Vargas-Poussou R, 2016, J CLIN ENDOCR METAB, V101, P2185, DOI 10.1210/jc.2015-3442
   Veldhuis-Vlug AG, 2012, J CLIN ENDOCR METAB, V97, pE2093, DOI 10.1210/jc.2012-2823
   Verly E, 2024, J CLIN ENDOCR METAB, V110, pe783, DOI 10.1210/clinem/dgae239
   Walker E, 2024, BEST PRACT RES CL EN, V38, DOI 10.1016/j.beem.2023.101843
   Wang Q, 2024, ORPHANET J RARE DIS, V19, DOI 10.1186/s13023-024-03135-8
   Yamada S, 2018, NEPHROLOGY, V23, P963, DOI 10.1111/nep.13246
   Zhang C, 2019, BONE, V121, P212, DOI 10.1016/j.bone.2019.01.021
   Zhu ZW, 2023, KIDNEY INT, V105, P1058, DOI 10.1016/j.kint.2024.01.031
NR 75
TC 1
Z9 1
U1 0
U2 0
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0003-4266
EI 2213-3941
J9 ANN ENDOCRINOL-PARIS
JI Ann Endocrinol.
PD FEB
PY 2025
VL 86
IS 1
AR 101693
DI 10.1016/j.ando.2025.101693
EA JAN 2025
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA T9E3N
UT WOS:001407947200001
PM 39818292
DA 2025-06-11
ER

PT J
AU Mehta, R
   Birerdinc, A
   Younossi, ZM
AF Mehta, Rohini
   Birerdinc, Aybike
   Younossi, Zobair M.
TI Host Genetic Variants in Obesity-Related Nonalcoholic Fatty Liver
   Disease
SO CLINICS IN LIVER DISEASE
LA English
DT Article
DE SNP; GWAS; Polymorphism; Steatosis
ID TRIGLYCERIDE TRANSFER PROTEIN; NECROSIS-FACTOR-ALPHA; LEPTIN RECEPTOR
   GENE; METABOLIC SYNDROME; PROMOTER POLYMORPHISM; JAPANESE PATIENTS; HFE
   MUTATIONS; UNITED-STATES; HEPATIC IRON; TRANSCRIPTION FACTORS
AB Nonalcoholic fatty liver disease (NAFLD) is a complex disease. The considerable variability in the natural history of the disease suggests an important role for genetic variants in the disease development and progression. There is evidence based on genome-wide association studies and/or candidate gene studies that genetic polymorphisms underlying insulin signaling, lipid metabolism, oxidative stress, fibrogenesis, and inflammation can predispose individuals to NAFLD. This review highlights some of the genetic variants in NAFLD.
C1 [Mehta, Rohini; Birerdinc, Aybike; Younossi, Zobair M.] Inova Hlth Syst, Ctr Liver Dis, Betty & Guy Beatty Ctr Integrated Res, Falls Church, VA 22042 USA.
   [Birerdinc, Aybike] George Mason Univ, Sch Syst Biol, Ctr Study Chron Metab Dis, Fairfax, VA 22030 USA.
   [Younossi, Zobair M.] Inova Fairfax Hosp, Ctr Liver Dis, Dept Med, Falls Church, VA 22042 USA.
C3 Inova Health System; George Mason University; Inova Fairfax Hospital
RP Younossi, ZM (corresponding author), Inova Hlth Syst, Inova Fairfax Hosp, Dept Med, VCU Inova Campus, Falls Church, VA USA.
EM Zobair.Younossi@inova.org
RI Younossi, Zobair M./JRY-9916-2023
CR Adams LA, 2013, HEPATOLOGY, V57, P590, DOI 10.1002/hep.26184
   Ahmed U, 2012, WORLD J GASTROENTERO, V18, P4651, DOI 10.3748/wjg.v18.i34.4651
   Alam S, 2013, WORLD J HEPATOL, V5, P281, DOI 10.4254/wjh.v5.i5.281
   Aller R, 2012, EUR REV MED PHARMACO, V16, P335
   Amarapurkar D, 2007, ANN HEPATOL, V6, P161, DOI 10.1016/S1665-2681(19)31922-2
   Aminoff A, 2010, J LIPID RES, V51, P103, DOI 10.1194/jlr.M900195-JLR200
   Auinger A, 2010, HORM METAB RES, V42, P854, DOI 10.1055/s-0030-1267186
   Beer NL, 2009, HUM MOL GENET, V18, P4081, DOI 10.1093/hmg/ddp357
   Bernard S, 2000, DIABETOLOGIA, V43, P995, DOI 10.1007/s001250051481
   Bonkovsky HL, 1999, J HEPATOL, V31, P421, DOI 10.1016/S0168-8278(99)80032-4
   BRIGGS MR, 1993, J BIOL CHEM, V268, P14490
   Browning JD, 2004, HEPATOLOGY, V40, P1387, DOI 10.1002/hep.20466
   Caballería L, 2010, EUR J GASTROEN HEPAT, V22, P24, DOI 10.1097/MEG.0b013e32832fcdf0
   Charlton MR, 2011, GASTROENTEROLOGY, V141, P1249, DOI 10.1053/j.gastro.2011.06.061
   Chen SH, 2008, J GASTROEN HEPATOL, V23, P1415, DOI 10.1111/j.1440-1746.2008.05523.x
   Chitturi S, 2002, HEPATOLOGY, V36, P142, DOI 10.1053/jhep.2002.33892
   Corbin KD, 2012, CURR OPIN GASTROEN, V28, P159, DOI 10.1097/MOG.0b013e32834e7b4b
   Daghestani MH, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-90
   Day CP, 2006, LIVER INT, V26, P1021, DOI 10.1111/j.1478-3231.2006.01323.x
   Dixon JB, 2003, J HEPATOL, V39, P967, DOI 10.1016/S0168-8278(03)00459-8
   Doege H, 2008, J BIOL CHEM, V283, P22186, DOI 10.1074/jbc.M803510200
   Dong H, 2007, J HEPATOL, V46, P915, DOI 10.1016/j.jhep.2006.12.012
   Dongiovanni P, 2010, BMC GASTROENTEROL, V10, DOI 10.1186/1471-230X-10-102
   Duseja A, 2012, J GASTROEN HEPATOL, V27, P848, DOI 10.1111/j.1440-1746.2012.07103.x
   Duvnjak M, 2009, WORLD J GASTROENTERO, V15, P6023, DOI 10.3748/wjg.15.6023
   Feder JN, 1996, NAT GENET, V13, P399, DOI 10.1038/ng0896-399
   Frigerio S, 1999, CANCER GENET CYTOGEN, V109, P172, DOI 10.1016/S0165-4608(98)00161-7
   Gambino R, 2007, HEPATOLOGY, V45, P1097, DOI 10.1002/hep.21631
   George DK, 1998, GASTROENTEROLOGY, V114, P311, DOI 10.1016/S0016-5085(98)70482-2
   Guyader D, 2008, J HEPATOL, V48, P514, DOI 10.1016/j.jhep.2007.12.002
   HAGAN DL, 1994, J BIOL CHEM, V269, P28737
   Hernaez R, 2012, GASTROENT HEPAT-BARC, V35, P32, DOI 10.1016/j.gastrohep.2011.08.002
   Hernaez R, 2011, J HEPATOL, V55, P1079, DOI 10.1016/j.jhep.2011.02.013
   Hooper AJ, 2011, J LIPID RES, V52, P593, DOI 10.1194/jlr.R008896
   Hui Y, 2008, LIVER INT, V28, P385, DOI 10.1111/j.1478-3231.2007.01623.x
   Iwamoto N, 2001, CLIN CHIM ACTA, V314, P85, DOI 10.1016/S0009-8981(01)00633-7
   Karpe F, 1998, ARTERIOSCL THROM VAS, V18, P756, DOI 10.1161/01.ATV.18.5.756
   Kotronen A, 2009, DIABETOLOGIA, V52, P1056, DOI 10.1007/s00125-009-1285-z
   Lazo M, 2013, AM J EPIDEMIOL, V178, P38, DOI 10.1093/aje/kws448
   Ledmyr H, 2002, J LIPID RES, V43, P51
   Lee JY, 2007, J HEPATOL, V47, P239, DOI 10.1016/j.jhep.2007.02.007
   Lee SH, 2010, J CLIN GASTROENTEROL, V44, pE154, DOI 10.1097/MCG.0b013e3181d347d9
   Lee UE, 2011, BEST PRACT RES CL GA, V25, P195, DOI 10.1016/j.bpg.2011.02.005
   Lehner R, 2012, ARTERIOSCL THROM VAS, V32, P1087, DOI 10.1161/ATVBAHA.111.241497
   LEWIS CM, 2012, COLD SPRING HARB PRO, V2012, DOI DOI 10.1101/PDB.T0P068163.PDB.T0P068163
   Li WW, 1995, J CLIN INVEST, V96, P2601, DOI 10.1172/JCI118324
   Liggett SB, 2000, PHARMACOLOGY, V61, P167, DOI 10.1159/000028397
   Lu HY, 2009, J GASTROEN HEPATOL, V24, P228, DOI 10.1111/j.1440-1746.2008.05544.x
   Lvovs D, 2012, ACTA NATURAE, V4, P59, DOI 10.32607/20758251-2012-4-3-59-71
   Marcos A, 2000, TRANSPLANTATION, V69, P2410, DOI 10.1097/00007890-200006150-00034
   Oliveira CPMS, 2010, J GASTROEN HEPATOL, V25, P357, DOI 10.1111/j.1440-1746.2009.06001.x
   McHutchison JG, 2011, LIVER INT, V31, P29, DOI 10.1111/j.1478-3231.2010.02389.x
   Mehta R, 2012, CLIN LIVER DIS, V1, P111, DOI DOI 10.1002/C1D.27
   MERIKA M, 1993, MOL CELL BIOL, V13, P3999, DOI 10.1128/MCB.13.7.3999
   Miller M, 2007, ARCH MED RES, V38, P444, DOI 10.1016/j.arcmed.2006.10.013
   Mura C, 1999, BLOOD, V93, P2502, DOI 10.1182/blood.V93.8.2502.408k27_2502_2505
   Musso G, 2008, HEPATOLOGY, V47, P1167, DOI 10.1002/hep.22142
   Nabeshima Y, 2009, J HEPATOL, V50, P1226, DOI 10.1016/j.jhep.2009.01.018
   Namikawa C, 2004, J HEPATOL, V40, P781, DOI 10.1016/j.jhep.2004.01.028
   Nozaki Y, 2004, ALCOHOL CLIN EXP RES, V28, p106S, DOI 10.1097/01.ALC.0000134410.42980.5E
   Peng XE, 2014, LIVER INT, V34, P118, DOI 10.1111/liv.12220
   Petersen KF, 2010, NEW ENGL J MED, V362, P1082, DOI 10.1056/NEJMoa0907295
   Pollex RL, 2007, BMC MED GENET, V8, DOI 10.1186/1471-2350-8-80
   Polyzos SA, 2010, DIABETES OBES METAB, V12, P365, DOI 10.1111/j.1463-1326.2009.01176.x
   Raszeja-Wyszomirska J, 2010, WORLD J GASTROENTERO, V16, P2531, DOI 10.3748/wjg.v16.i20.2531
   Reue K, 2008, FEBS LETT, V582, P90, DOI 10.1016/j.febslet.2007.11.014
   Rey JW, 2010, WORLD J GASTROENTERO, V16, P5830, DOI 10.3748/wjg.v16.i46.5830
   Romeo S, 2010, INT J OBESITY, V34, P190, DOI 10.1038/ijo.2009.216
   Romeo S, 2008, NAT GENET, V40, P1461, DOI 10.1038/ng.257
   Romeo S, 2006, FASEB J, V20, P2180, DOI 10.1096/fj.06-1004ufm
   Rosca MG, 2012, DIABETES, V61, P2074, DOI 10.2337/db11-1437
   Rubin D, 2008, HUM MUTAT, V29, P123, DOI 10.1002/humu.20615
   Sazci A, 2008, CELL BIOCHEM FUNCT, V26, P291, DOI 10.1002/cbf.1424
   Scott JD, 2008, WORLD J GASTROENTERO, V14, P4607, DOI 10.3748/wjg.14.4607
   SHARP D, 1994, BIOCHEMISTRY-US, V33, P9057, DOI 10.1021/bi00197a005
   Siqueira ERF, 2011, NUTR J, V10, DOI 10.1186/1475-2891-10-86
   Song JN, 2005, FASEB J, V19, P1266, DOI 10.1096/fj.04-3580com
   Sookoian S, 2011, HEPATOLOGY, V53, P1883, DOI 10.1002/hep.24283
   Sparso T, 2007, MOL GENET METAB, V90, P205, DOI 10.1016/j.ymgme.2006.10.007
   Speliotes EK, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1001324
   Tilg H, 2010, DIGEST DIS, V28, P179, DOI 10.1159/000282083
   Tokushige K, 2007, J HEPATOL, V46, P1104, DOI 10.1016/j.jhep.2007.01.028
   Tokushige K, 2009, J GASTROENTEROL, V44, P976, DOI 10.1007/s00535-009-0085-z
   Valenti L, 2002, GASTROENTEROLOGY, V122, P274, DOI 10.1053/gast.2002.31065
   Valenti L, 2012, J PEDIATR GASTR NUTR, V54, P588, DOI 10.1097/MPG.0b013e3182442a55
   Valenti L, 2011, J HEPATOL, V55, P1409, DOI 10.1016/j.jhep.2011.03.035
   Valenti L, 2010, HEPATOLOGY, V51, P1209, DOI 10.1002/hep.23622
   Vernon G, 2011, ALIMENT PHARM THER, V34, P274, DOI 10.1111/j.1365-2036.2011.04724.x
   Wallace DF, 2002, J HEPATOL, V36, P474, DOI 10.1016/S0168-8278(01)00304-X
   Wang JK, 2012, J GASTROEN HEPATOL, V27, P670, DOI 10.1111/j.1440-1746.2011.06978.x
   Wang ZL, 2008, J ENDOCRINOL INVEST, V31, P1086, DOI 10.1007/BF03345657
   Watkins SM, 2003, J NUTR, V133, P3386, DOI 10.1093/jn/133.11.3386
   Wingender E, 1996, NUCLEIC ACIDS RES, V24, P238, DOI 10.1093/nar/24.1.238
   Wong VWS, 2008, J GASTROEN HEPATOL, V23, P914, DOI 10.1111/j.1440-1746.2008.05344.x
   Yoneda M, 2008, BMC GASTROENTEROL, V8, DOI 10.1186/1471-230X-8-27
   Yoneda M, 2009, LIVER INT, V29, P1078, DOI 10.1111/j.1478-3231.2009.01988.x
   Yuan X, 2008, AM J HUM GENET, V83, P520, DOI 10.1016/j.ajhg.2008.09.012
   Zain SM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0058538
   Zain SM, 2013, J GASTROEN HEPATOL, V28, P873, DOI 10.1111/jgh.12104
NR 99
TC 9
Z9 10
U1 0
U2 13
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1089-3261
EI 1557-8224
J9 CLIN LIVER DIS
JI Clin. Liver Dis.
PD FEB
PY 2014
VL 18
IS 1
BP 249
EP +
DI 10.1016/j.cid.2013.09.017
PG 20
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 278VL
UT WOS:000328917900019
PM 24274878
DA 2025-06-11
ER

PT J
AU Wang, Y
   Chen, WJ
   Li, MQ
   Zhou, L
   Jin, YA
   Jin, JZ
   Li, CY
AF Wang, Yan
   Chen, Wen-Jun
   Li, Mei-Qian
   Zhou, Li
   Jin, Ying-Ai
   Jin, Jin-Zhen
   Li, Chun-Yu
TI Nursing Interventions for Patients With Hypertension, Diabetes and
   Dyslipidemia: A Scoping Review
SO JOURNAL OF ADVANCED NURSING
LA English
DT Review; Early Access
DE diabetes; dyslipidemia; hypertension; metabolic syndrome; scoping review
ID HEALTH-CARE; DISEASE; PREVENTION; ADHERENCE
AB AimsTo conduct a comprehensive assessment of nursing interventions for patients with hypertension, diabetes, and dyslipidemia and analyse the components, delivery methods and outcomes of intervention programmes. DesignScoping review. Data SourcesSystematic searches were performed in four Chinese databases (WanFang, CNKI, Chinese Biomedical Literature Database, and the VIP database) and six English databases (CINAHL, MEDLINE, Web of Science, PubMed, Embase, The Cochrane Library) from their inception until October 2023. An updated search was performed on 6 August 2024. MethodsTwo reviewers independently retrieved full-text studies and conducted the initial screening of titles and abstracts, followed by full-text analysis and data extraction. ResultsA total of 49 articles were included in this review. The nursing interventions consisted of various components, including fitness exercise, a balanced diet, mental health support, medication administration and others. The most commonly used delivery method was health education, with an increasing trend towards online interventions. However, the included studies did not provide details on delivery methods, including the team qualifications, subject areas or intervention duration and frequency. The nursing interventions achieved their research aims to varying degrees, as measured by subjective and/or objective indicators. ConclusionThe nursing interventions for the three highs are diverse, including offline, online and combined methods, covering exercise, diet, and mental health. Future efforts can draw on these intervention components and methods and establish a nurse-led multidisciplinary team. The measurement of objective indicators, including blood lipids, should be taken seriously. Developing more diverse subjective measurement indicators can comprehensively assess patients' health. ImpactThis review offers clear guidance for the subsequent prevention and management of the three highs and consolidates evidence for healthcare professionals to devise targeted intervention strategies. Reporting MethodWe followed Arksey's five-step framework and the PRISMA extension for scoping reviews (PRISMA-ScR). Patient or Public ContributionNo.
C1 [Wang, Yan] Yanbian Univ, Sch Med, Yanji, Jilin, Peoples R China.
   [Chen, Wen-Jun] Cent South Univ, Xiangya Sch Nursing, Changsha, Hunan, Peoples R China.
   [Li, Mei-Qian] Shandong Xiandai Univ, Jinan, Shandong, Peoples R China.
   [Zhou, Li] Jiaxing Univ, Sch Med, Jiaxing, Zhejiang, Peoples R China.
   [Jin, Ying-Ai] Yanbian Univ, Dept Nursing, Affiliated Hosp, Yanji, Jilin, Peoples R China.
   [Jin, Jin-Zhen] Yanbian Univ, Yanji, Jilin, Peoples R China.
   [Li, Chun-Yu] Yanbian Univ, Sch Nursing, Yanji, Jilin, Peoples R China.
C3 Yanbian University; Central South University; Jiaxing University;
   Yanbian University; Yanbian University; Yanbian University
RP Li, CY (corresponding author), Yanbian Univ, Sch Nursing, Yanji, Jilin, Peoples R China.
EM 2542223095@qq.com
OI Wang, Yan/0000-0002-7308-8301; li, meiqian/0009-0004-4831-0451
FU Special Project for Promoting the Scientific Research and Innovation
   Capabilities of Doctoral Students (Science and Technology) of the Jilin
   Provincial Department of Education in 2025
FX We express our gratitude to the Special Project for Promoting the
   Scientific Research and Innovation Capabilities of Doctoral Students
   (Science and Technology) of the Jilin Provincial Department of Education
   in 2025 for recognising our research.
CR Alkhulaifi F, 2022, NUTRIENTS, V14, DOI 10.3390/nu14091719
   Arksey H., 2005, INT J SOC RES METHOD, V8, P19, DOI [DOI 10.1080/1364557032000119616, 10.1080/1364557032000119616]
   Athinarayanan SJ, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00348
   Baker R, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005470.pub3
   Bao H. L., 2010, Chinese Journal of Social Medicine, V27, P165
   Behl TA, 2023, AM J LIFESTYLE MED, V17, P397, DOI 10.1177/15598276221111046
   Beijing Hypertension Association China Association of Gerontology and Geriatrics Beijing Community Health Service Association Beijing Community Health Promotion Association, 2024, Chinese General Practice, V27, P3453
   Bingham JM, 2021, ANN PHARMACOTHER, V55, P637, DOI 10.1177/1060028020950726
   Biswas RK, 2024, HEALTH SCI REP-US, V7, DOI 10.1002/hsr2.2243
   Bosworth HB, 2018, PATIENT PREFER ADHER, V12, P341, DOI 10.2147/PPA.S153766
   Bragge P, 2017, BMC MED RES METHODOL, V17, DOI 10.1186/s12874-017-0314-8
   Chau JPC, 2021, COMPLEMENT THER CLIN, V44, DOI 10.1016/j.ctcp.2021.101445
   Che TT, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.773646
   Chen W. W., 2017, Chronic Pathematology Journal, V18, P833
   Chen X. L., 2021, Women's Health, V32
   Chomiuk T, 2024, FRONT PHYSIOL, V15, DOI 10.3389/fphys.2024.1365761
   Chong BY, 2023, METABOLISM, V141, DOI 10.1016/j.metabol.2023.155402
   Dong X. L., 2022, HealthmustReadmagazine, V20
   El Haddad L, 2023, PATIENT PREFER ADHER, V17, P311, DOI 10.2147/PPA.S383482
   Fenwick PH, 2019, CRIT REV FOOD SCI, V59, P2028, DOI 10.1080/10408398.2018.1437022
   Fu M. J., 2013, China Medicalherald, V10, P55
   Gallardo-Alfaro L, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041013
   Gorina M, 2018, INT J NURS STUD, V86, P139, DOI 10.1016/j.ijnurstu.2018.06.016
   Guo H. J., 2021, Guide of China Medicine, V19, P11
   He G. H., 2013, Henan Traditional Chinese Medicine, V33, P295
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Hu X. L., 2023, Diabetes World, V2, P238
   Huang D. L., 2023, Journal of Qilu Nursing, V29, P103
   Ji S, 2023, FRONT PSYCHIATRY, V14, DOI 10.3389/fpsyt.2023.1118836
   Jiang C. P., 2020, Cardiovascular Disease Electronic Journal of integrated traditional Chinese and Western Medicine, V8, P120
   Kim CJ, 2023, J CLIN NURS, V32, P5328, DOI 10.1111/jocn.16589
   Kim HB, 2023, J AFFECT DISORDERS, V323, P46, DOI 10.1016/j.jad.2022.11.049
   Leong DP, 2017, CIRC RES, V121, P695, DOI 10.1161/CIRCRESAHA.117.311849
   Li L. H., 2020, Medical Forum, V24, P3860
   Li L. J., 2021, Chinese Health Care, V18, P39
   Li M. Y., 2018, Health Way, V17, P27
   Li X. N., 2019, Jilin Medical Journal, V40, P648
   Liang H. L., 2020, Diabetes World, V17, P266
   Liang W. J., 2018, Medical Diet and Health, V9, P17
   Liu Q., 2016, Contemporary Medicine, V22, P3
   Liu T. T., 2020, Oriental Medicated Diet, V4, P136
   Liu YanHua Liu YanHua, 2018, Chinese Journal of Nosocomiology, V28, P143
   Lu J., 2023, Health Home, V8, P135
   Lu P., 2021, China Health Care Nutrition, V31, P126
   Lu Y. Q., 2012, Journal of Practical Medicine, V28, P2960
   Luo YaoMing Luo YaoMing, 2019, Asian Agricultural Research, V11, P25
   Lv A. N., 2022, Prevention and Treatment of Cardiovascular Disease, V12, P39
   Lyons KS, 2018, J FAM NURS, V24, P8, DOI 10.1177/1074840717745669
   Ma J., 2016, Contemporary Medicine, V22, P77
   Makovski TT, 2019, AGEING RES REV, V53, DOI 10.1016/j.arr.2019.04.005
   Manthey J, 2019, LANCET, V393, P2493, DOI 10.1016/S0140-6736(18)32744-2
   Marupuru S. A., 2022, A Systematic Review of Clinical Outcomes from Pharmacist Provided Medication Therapy Management (MTM) among Patients with Diabetes, Hypertension, or Dyslipidemia
   Marzano M, 2023, J CLIN NURS, V32, P7707, DOI 10.1111/jocn.16867
   Moradi Yousef, 2021, Clin Diabetes Endocrinol, V7, P4, DOI 10.1186/s40842-021-00117-8
   Mu H. Y., 2018, Psychologist, V24, P207
   Nizamani S, 2022, DIAB MET SYND CLIN R, V16, DOI 10.1016/j.dsx.2022.102662
   Noubiap JJ, 2022, DIABETES RES CLIN PR, V188, DOI 10.1016/j.diabres.2022.109924
   Nsabimana P, 2024, NUTR METAB CARDIOVAS, V34, P235, DOI 10.1016/j.numecd.2023.07.040
   Odorico M, 2019, VASC HEALTH RISK MAN, V15, P485, DOI 10.2147/VHRM.S221744
   Park M, 2018, INT J NURS STUD, V87, P69, DOI 10.1016/j.ijnurstu.2018.07.006
   Park S, 2024, J NURS SCHOLARSHIP, V56, P249, DOI 10.1111/jnu.12946
   Persaud-Lachhman M, 2020, TROP MED INT HEALTH, V25, P159, DOI 10.1111/tmi.13347
   Pirillo A, 2021, NAT REV CARDIOL, V18, P689, DOI 10.1038/s41569-021-00541-4
   Ramasawmy M, 2023, LANCET, V402, P78
   Riecke F, 2024, FRONT PUBLIC HEALTH, V12, DOI 10.3389/fpubh.2024.1313685
   Shi P. P., 2023, China Health Care Nutrition, V33, P34
   Shi Z. W., 2023, Chinese Journal of Cardiovascular Disease, V6, P1
   Skou ST, 2022, NAT REV DIS PRIMERS, V8, DOI 10.1038/s41572-022-00376-4
   Sun L. H., 2021, Cardiovascular Disease Electronic Journal of Integrated Traditional Chinese and Western Medicine, V9, P72
   Tan JP, 2019, J ADV NURS, V75, P2478, DOI 10.1111/jan.14025
   Tan Y., 2023, Chinese Science and Technology Journal Database (Full Text Version) Medicine and Health Care, V6, P151
   Tang Z., 2020, Journal of Frontiers of Medicine, V10, P202
   Tao XJ, 2023, BMJ OPEN, V13, DOI 10.1136/bmjopen-2022-070583
   Tricco AC, 2018, ANN INTERN MED, V169, P467, DOI 10.7326/M18-0850
   van Driel ML, 2018, HEART, V104, P367, DOI 10.1136/heartjnl-2017-311606
   Wang HN, 2023, FRONT PUBLIC HEALTH, V11, DOI 10.3389/fpubh.2023.1133614
   Wang MJ, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.846591
   Wang S., 2018, Electronic Journal of Practical Clinical Nursing Science, V3, P5
   Wang Y. Y., 2019, World of Diabetes, V16, P7
   Wang Z. H., 2013, China Health Care and Nutrition, V33, P2412
   Wang Z. X., 2022, SelfCare, V26, P261
   Wen P. E., 2019, Hainan Medical Journal, V30, P2143
   Whittaker R, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD006611.pub5
   Xie J, 2021, SLEEP MED REV, V59, DOI 10.1016/j.smrv.2021.101451
   Yan B. Y., 2021, Heilongjiang Medicine and Pharmacy, V44, P69
   Yu JL, 2023, IRAN J PUBLIC HEALTH, V52, P880, DOI 10.18502/ijph.v52i5.12705
   Yuan D. M., 2021, SelfCare, V7, P201
   Zhai J., 2022, Health Literacy, V23, P202
   Zhang J., 2016, Western Journal of Traditional Chinese Medicine, V29, P6
   Zhang Y. Q., 2021, HealthmustReadmagazine, V21, P198
   Zhang Y. Y., 2019, Chronic Pathematology Journal, V20, P1265
   Zhang Y. Y., 2021, Chinese Science and Technology Journal Database, V6, P54
   Zhang Z., Exploring the Effectiveness of Health Management in the Three Highs and Obesity Population in Health Checkups, V7, P161
   Zhao L., 2021, Electronic Journal of Clinical Medical Literature, V8, P71
   Zhao Y. H., 2021, Fertility Health, V11, P55
   Zheng X. X., 2016, Medical Forum, V20, P1271
   Zhou C., 2012, Chinese and Foreign Medical Research, V10, P89
   Zhou H. P., 2023, Studies of Trace Elements and Health, V40, P79
   Zhou JY, 2021, NUTRITION, V91-92, DOI 10.1016/j.nut.2021.111422
   Zhou Y. Q., 2022, World of Healthy Living, V13, P109
   Zou Q. M., 2019, Nursing Practice and Research, V16, P149
NR 101
TC 0
Z9 0
U1 6
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0309-2402
EI 1365-2648
J9 J ADV NURS
JI J. Adv. Nurs.
PD 2025 MAR 25
PY 2025
DI 10.1111/jan.16889
EA MAR 2025
PG 14
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 0NJ4S
UT WOS:001451487500001
PM 40130699
DA 2025-06-11
ER

PT J
AU Martínez-Hernández, GB
   Jiménez-Ferrer, E
   González-Cortazar, M
   Alejandro, Z
   Monterrosas-Brisson, N
   Herrera-Ruiz, M
AF Martinez-Hernandez, Gabriela Belen
   Jimenez-Ferrer, Enrique
   Gonzalez-Cortazar, Manases
   Alejandro, Zamilpa
   Monterrosas-Brisson, Nayeli
   Herrera-Ruiz, Maribel
TI Salvia elegans Vahl Counteracting Metabolic Syndrome and
   Depression in Mice on a High-Fat Diet
SO MOLECULES
LA English
DT Article
DE dyslipidemia; obesity; hypertension; central and systemic inflammation;
   inflammatory cytokines; serum corticosterone; sterols; phenolic
   compounds
ID FORCED SWIMMING TEST; ALPHA-D-GLUCOSIDE; HYDROALCOHOLIC EXTRACT;
   INSULIN-RESISTANCE; ROSMARINIC ACID; ADIPOSE-TISSUE; ANTIDEPRESSANT;
   OBESITY; AXIS; INTERLEUKIN-10
AB Salvia elegans Vahl is a plant commonly used in Mexico as a remedy for nervous disorders, inflammatory diseases, and "ringing in the ears"; the latter can be associated with arteriosclerotic conditions and arterial hypertension. Therefore, based on medicinal use, this work aimed to evaluate the hydroalcoholic extract (SeHA, 100 mg/kg) of this plant and two fractions, ethyl acetate (SeFAc, 50 mg/kg), and obtained from SeFAc fractionation denominated SeF3 (10 mg/kg), on several alterations derived from metabolic syndrome (MetS) derived from the ingestion of a high-calorie diet (high-fat diet), in ICR (Institute of Cancer Research) mice, leading to chronic inflammation that results in neurological damage such as depression. Therefore, several MetS-related parameters, such as forced swim tests, hypertension, serum corticosterone levels, glucose, triglycerides, cholesterol, adiposity index, and insulin resistance, will be evaluated. Additionally, tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, IL-6, and IL-10 levels were measured in kidneys, fat tissue, brains, and spleens. It was proven that all those S. elegans-derived treatments reversed the damage, showing antidepressant, antihypertensive, antihyperglycemic, and antidyslipidemic effects and decreased adiposity, insulin resistance, and serum corticosterone. They induced a modulatory response by modifying the levels of TNF-alpha, IL-1 beta, IL-6, and IL-10 in different organs. High-performance liquid chromatography (HPLC) analysis of the acetate of ethyl fraction from S. elegans (SeFAc) fraction revealed the presence of rosmarinic and caffeic acids as well as flavonoids, while the fraction from SeFAc called SeF3 Was identified by gas mass as methyl glucose, glycerol, and known sterols, among others. Thus, it was concluded that S. elegans protects against the harmful effects of MetS.
C1 [Martinez-Hernandez, Gabriela Belen; Jimenez-Ferrer, Enrique; Gonzalez-Cortazar, Manases; Alejandro, Zamilpa; Herrera-Ruiz, Maribel] Inst Mexicano Seguro Social IMSS, Ctr Invest Biomed, Argentina 1, Xochitepec 62790, Mexico.
   [Monterrosas-Brisson, Nayeli] Univ Autonoma Estado Morelos UAEM, Fac Ciencias Biol, Cuernavaca 62209, Morelos, Mexico.
C3 Instituto Mexicano del Seguro Social; Universidad Autonoma del Estado de
   Morelos
RP Herrera-Ruiz, M (corresponding author), Inst Mexicano Seguro Social IMSS, Ctr Invest Biomed, Argentina 1, Xochitepec 62790, Mexico.
EM gabmh89@gmail.com; enriqueferrer_mx@yahoo.com; gmanases@hotmail.com;
   azamilpa_2000@yahoo.com.mx; nayeli.monterrosas@uaem.mx;
   cibis_herj@yahoo.com.mx
RI Zamilpa, Alejandro/AAC-2241-2019; González-Cortazar,
   Manasés/AAL-6644-2020
OI Zamilpa, Alejandro/0000-0002-2233-5958; Gonzalez-Cortazar,
   Manases/0000-0002-3693-1670
FU Fondo de Investigation en Salud-Instituto Mexicano del Seguro Social; 
   [FIS/IMSS/PROT/PRIO/14/029]
FX This work was supported by Fondo de Investigation en Salud-Instituto
   Mexicano del Seguro Social number FIS/IMSS/PROT/PRIO/14/029 (E.J.-F.).
CR Aguilar A., 1994, Herbario Medicinal del Instituto Mexicano del Seguro Social. Informacin Etnobotnica, P159
   Akaberi M, 2016, PHYTOTHER RES, V30, P878, DOI 10.1002/ptr.5599
   Alexander-Lindo RL, 2004, PHYTOTHER RES, V18, P403, DOI 10.1002/ptr.1459
   [Anonymous], 2020, Obesity and overweight fact sheet
   [Anonymous], 2019, Hypertension. Fact Sheets
   Baek Y, 2019, J NUTR BIOCHEM, V71, P72, DOI 10.1016/j.jnutbio.2019.06.002
   Barriga C, 2001, J PINEAL RES, V30, P180, DOI 10.1034/j.1600-079X.2001.300307.x
   Martínez-Hernández GB, 2021, N-S ARCH PHARMACOL, V394, P2419, DOI 10.1007/s00210-021-02155-6
   Bocco BM, 2016, BRAZ J MED BIOL RES, V49, DOI 10.1590/1414-431X20155003
   Bonilla-Jaime H, 2022, CURR NEUROPHARMACOL, V20, P384, DOI 10.2174/1570159X19666210609161447
   Bruehl H, 2007, J CLIN ENDOCR METAB, V92, P2439, DOI 10.1210/jc.2006-2540
   Bunzel M, 2004, J AGR FOOD CHEM, V52, P6496, DOI 10.1021/jf040204p
   Capuron L, 2008, BIOL PSYCHIAT, V64, P896, DOI 10.1016/j.biopsych.2008.05.019
   Chan KL, 2019, PHYSIOLOGY, V34, P123, DOI 10.1152/physiol.00047.2018
   de Jong A, 2003, J NUTR BIOCHEM, V14, P362, DOI 10.1016/S0955-2863(03)00002-0
   De Souza CT, 2005, ENDOCRINOLOGY, V146, P4192, DOI 10.1210/en.2004-1520
   Duke J.A., 1992, Handbook of Phytochemical Constituents of GRAS Herbs and Other Economic Plants, P325
   Duke J.A., 1992, Handbook of Phytochemical Constituents of GRAS Herbs and Other Economic Plants, P247
   Esposito K, 2003, J CLIN ENDOCR METAB, V88, P1055, DOI 10.1210/jc.2002-021437
   González-Cortazar M, 2013, MOLECULES, V18, P13260, DOI 10.3390/molecules181113260
   Gotoh K, 2012, J NEUROCHEM, V120, P752, DOI 10.1111/j.1471-4159.2011.07617.x
   Gutiérrez-Roman AS, 2021, NAT PROD RES, V35, P5344, DOI 10.1080/14786419.2020.1758093
   Harsanyi S, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24010578
   Herrera-Ruiz M, 2006, J ETHNOPHARMACOL, V107, P53, DOI 10.1016/j.jep.2006.02.003
   Jimenez-Ferrer E, 2010, J ETHNOPHARMACOL, V130, P340, DOI 10.1016/j.jep.2010.05.013
   Jin ES, 2023, REDOX BIOL, V63, DOI 10.1016/j.redox.2023.102749
   Koga K, 2006, J FOOD SCI, V71, pS507, DOI 10.1111/j.1750-3841.2006.00125.x
   Kojima Y, 2020, J AGR FOOD CHEM, V68, P1419, DOI 10.1021/acs.jafc.9b06936
   Lamas O, 2004, J PHYSIOL BIOCHEM, V60, P279, DOI 10.1007/BF03167074
   Lebeck J, 2014, J MOL ENDOCRINOL, V52, pR165, DOI 10.1530/JME-13-0268
   Lieder B, 2019, MOLECULES, V24, DOI 10.3390/molecules24193599
   Lim T.K., 2014, Edible Medicinal and Non Medicinal Plants, P202
   Mahendran Y, 2013, DIABETES CARE, V36, P3732, DOI 10.2337/dc13-0800
   McCue PP, 2004, ASIA PAC J CLIN NUTR, V13, P101
   Mishima T, 2005, NUTRITION, V21, P525, DOI 10.1016/j.nut.2004.08.024
   Mishima T, 2005, J NUTR SCI VITAMINOL, V51, P22, DOI 10.3177/jnsv.51.22
   Mora S, 2006, J ETHNOPHARMACOL, V106, P76, DOI 10.1016/j.jep.2005.12.004
   Mueller M, 2008, J AGR FOOD CHEM, V56, P11621, DOI 10.1021/jf802298w
   Najafi N, 2022, PHYTOTHER RES, V36, P2300, DOI 10.1002/ptr.7406
   Ouakinin SRS, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00431
   Pan Q, 2019, METAB BRAIN DIS, V34, P747, DOI 10.1007/s11011-019-0392-x
   Pasquali R, 2006, ANN NY ACAD SCI, V1083, P111, DOI 10.1196/annals.1367.009
   Pereira OR, 2018, MOLECULES, V23, DOI 10.3390/molecules23123169
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Rogóz Z, 2005, J PHYSIOL PHARMACOL, V56, P49
   Ruanpang Jutamas, 2018, Chiang Mai University Journal of Natural Sciences, V17, P161, DOI 10.12982/CMUJNS.2018.0012
   Rydén M, 2007, J INTERN MED, V262, P431, DOI 10.1111/j.1365-2796.2007.01854.x
   Sharma S, 2013, INT J OBESITY, V37, P382, DOI 10.1038/ijo.2012.48
   Spoto B, 2013, NEPHROL DIAL TRANSPL, V28, P1061, DOI 10.1093/ndt/gft094
   Takeda H, 2002, EUR J PHARMACOL, V449, P261, DOI 10.1016/S0014-2999(02)02037-X
   Tanaka M, 2006, BIOL PHARM BULL, V29, P1418, DOI 10.1248/bpb.29.1418
   Tannenbaum Beth M., 1997, American Journal of Physiology, V273, pE1168
   Wasan KM, 2003, J PHARM SCI-US, V92, P281, DOI 10.1002/jps.10297
   World Health Organization, 2020, Depression fact sheet
   Zhao DH, 2016, MAR DRUGS, V14, DOI 10.3390/md14070123
NR 55
TC 0
Z9 0
U1 3
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD SEP
PY 2024
VL 29
IS 17
AR 4070
DI 10.3390/molecules29174070
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA F7G9P
UT WOS:001311471900001
PM 39274918
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dixon, AE
   Holguin, F
AF Dixon, Anne E.
   Holguin, Fernando
TI Diet and Metabolism in the Evolution of Asthma and Obesity
SO CLINICS IN CHEST MEDICINE
LA English
DT Article
DE Diet; Obesity; Asthma; Microbiome; Airway reactivity; Metabolic
   syndrome; Immunometabolism
ID BODY-MASS INDEX; WEIGHT-LOSS; SYSTEMIC INFLAMMATION; AEROBIC EXERCISE;
   LUNG-FUNCTION; AIRWAY INFLAMMATION; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; BARIATRIC SURGERY; GUT MICROBIOTA
AB Obesity is a major risk factor for asthma. This association appears related to altered dietary composition and metabolic factors that can directly affect airway reactivity and airway inflammation. This article discusses how specific changes in the western diet and metabolic changes associated with the obese state affect inflammation and airway reactivity and reviews evidence that interventions targeting weight, dietary components, lifestyle, and metabolism might improve outcomes in asthma.
C1 [Dixon, Anne E.] Univ Vermont, Div Pulm & Crit Care, Given D209,89 Beaumont Ave, Burlington, VT 05482 USA.
   [Holguin, Fernando] Univ Colorado, Dept Med, Div Pulm & Crit Care, Denver, CO 80045 USA.
   [Holguin, Fernando] Allergy & Asthma Clin, Anschutz 1635 Aurora Court,6th Floor, Aurora, CO 80045 USA.
C3 University of Vermont; University of Colorado System; University of
   Colorado Anschutz Medical Campus; University of Colorado Denver
RP Dixon, AE (corresponding author), Univ Vermont, Div Pulm & Crit Care, Given D209,89 Beaumont Ave, Burlington, VT 05482 USA.
EM Anne.dixon@uvmhealth.org
FU NIH [HL133920, HL136917]
FX This article is funded by NIH grants HL133920 and HL136917.
CR Agrawal A, 2011, AM J RESP CELL MOL, V44, P270, DOI 10.1165/rcmb.2010-0141TR
   Anderson WJ, 2012, ANN ALLERG ASTHMA IM, V108, P237, DOI 10.1016/j.anai.2011.12.006
   Assad N, 2013, AM J RESP CRIT CARE, V188, P319, DOI 10.1164/rccm.201303-0457OC
   Bähr I, 2018, IMMUNOL RES, V66, P234, DOI 10.1007/s12026-018-8989-4
   Beltrán-Sánchez H, 2013, J AM COLL CARDIOL, V62, P697, DOI 10.1016/j.jacc.2013.05.064
   Boyd A, 2012, ALLERGY ASTHMA CL IM, V8, DOI 10.1186/1710-1492-8-13
   Brigham EP, 2018, ANN AM THORAC SOC, V15, P675, DOI 10.1513/AnnalsATS.201707-571OC
   Brumpton BM, 2013, EUR RESPIR J, V42, P1495, DOI 10.1183/09031936.00046013
   Calixto MC, 2010, BRIT J PHARMACOL, V159, P617, DOI 10.1111/j.1476-5381.2009.00560.x
   Cameron AJ, 2004, ENDOCRIN METAB CLIN, V33, P351, DOI 10.1016/j.ecl.2004.03.005
   Cardet JC, 2016, EUR RESPIR J, V48, P403, DOI 10.1183/13993003.00246-2016
   Carrier A, 2017, ANTIOXID REDOX SIGN, V26, P429, DOI 10.1089/ars.2016.6929
   Cottrell L, 2011, AM J RESP CRIT CARE, V183, P441, DOI 10.1164/rccm.201004-0603OC
   Dahm PH, 2014, AM J PHYSIOL-REG I, V307, pR621, DOI 10.1152/ajpregu.00205.2014
   Dekkers BGJ, 2009, AM J RESP CELL MOL, V41, P494, DOI 10.1165/rcmb.2008-0251OC
   Deopurkar R, 2010, DIABETES CARE, V33, P991, DOI 10.2337/dc09-1630
   Dias SA, 2014, EUR RESPIR J, V43, P1368, DOI 10.1183/09031936.00053413
   Dixon AE, 2016, AM J RESP CELL MOL, V54, P601, DOI 10.1165/rcmb.2016-0017PS
   Dixon AE, 2011, J ALLERGY CLIN IMMUN, V128, P508, DOI 10.1016/j.jaci.2011.06.009
   Dugger KJ, 2013, BRAIN BEHAV IMMUN, V34, P67, DOI 10.1016/j.bbi.2013.07.011
   Forno E, 2015, J ALLERGY CLIN IMMUN, V136, P304, DOI 10.1016/j.jaci.2015.01.010
   França-Pinto A, 2015, THORAX, V70, P732, DOI 10.1136/thoraxjnl-2014-206070
   Frasca D, 2016, OBESITY, V24, P615, DOI 10.1002/oby.21383
   Freitas PD, 2017, AM J RESP CRIT CARE, V195, P32, DOI [10.1164/rccm.201603-0446OC, 10.1164/rccm.201603-0446oc]
   Fricke K, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-24759-4
   Gérard P, 2016, CELL MOL LIFE SCI, V73, P147, DOI 10.1007/s00018-015-2061-5
   Hales CM, 2018, JAMA-J AM MED ASSOC, V319, P1723, DOI 10.1001/jama.2018.3060
   Halnes I, 2017, NUTRIENTS, V9, DOI 10.3390/nu9010057
   Han YY, 2018, J ALLER CL IMM-PRACT, V6, P834, DOI 10.1016/j.jaip.2017.12.029
   Hasegawa K, 2015, J ALLERGY CLIN IMMUN, V136, P288, DOI 10.1016/j.jaci.2014.12.1931
   Hernandez Romero Azael, 2008, Rev Alerg Mex, V55, P103
   Hewitt M, 2010, AM J RESP CELL MOL, V42, P243, DOI 10.1165/rcmb.2009-0038OC
   Holguin F, 2013, AM J RESP CRIT CARE, V187, P153, DOI 10.1164/rccm.201207-1270OC
   Holguin F, 2010, J APPL PHYSIOL, V108, P754, DOI 10.1152/japplphysiol.00702.2009
   Jensen ME, 2013, CLIN EXP ALLERGY, V43, P775, DOI 10.1111/cea.12115
   Johnson JB, 2007, FREE RADICAL BIO MED, V42, P665, DOI 10.1016/j.freeradbiomed.2006.12.005
   Johnston RA, 2007, AM J RESP CRIT CARE, V176, P650, DOI 10.1164/rccm.200702-323OC
   Kien CL, 2015, J NUTR BIOCHEM, V26, P1599, DOI 10.1016/j.jnutbio.2015.07.014
   Kim SK, 2017, PLOS ONE, V12, P3
   Kuschnir FC, 2018, J ALLERGY CLIN IMMUN, V141, P1947, DOI 10.1016/j.jaci.2018.01.026
   Lee EJ, 2009, J ASTHMA, V46, P339, DOI 10.1080/02770900802660931
   Lee H, 2014, AM J RESP CELL MOL, V50, P667, DOI 10.1165/rcmb.2013-0397TR
   Leone N, 2009, AM J RESP CRIT CARE, V179, P509, DOI 10.1164/rccm.200807-1195OC
   Lim SY, 2010, J KOREAN MED SCI, V25, P1480, DOI 10.3346/jkms.2010.25.10.1480
   Lowder T, 2010, BRAIN BEHAV IMMUN, V24, P153, DOI 10.1016/j.bbi.2009.09.011
   Lugogo NL, 2011, BBA-GEN SUBJECTS, V1810, P1120, DOI 10.1016/j.bbagen.2011.09.004
   Ma J, 2016, EUR RESPIR J, V47, P122, DOI 10.1183/13993003.00591-2015
   Ma J, 2015, ANN AM THORAC SOC, V12, P1, DOI 10.1513/AnnalsATS.201406-271OC
   Mendes FAR, 2010, CHEST, V138, P331, DOI 10.1378/chest.09-2389
   Nie ZY, 2014, AM J RESP CELL MOL, V51, P251, DOI 10.1165/rcmb.2013-0452OC
   Olivo CR, 2012, RESP PHYSIOL NEUROBI, V182, P81, DOI 10.1016/j.resp.2012.05.004
   Pakhale S, 2015, CHEST, V147, P1582, DOI 10.1378/chest.14-3105
   Pattnaik B, 2016, J ALLERGY CLIN IMMUN, V138, P130, DOI 10.1016/j.jaci.2015.11.036
   Peters U, 2018, CHEST, V153, P702, DOI 10.1016/j.chest.2017.07.010
   Ralston JC, 2017, ANNU REV NUTR, V37, P77, DOI 10.1146/annurev-nutr-071816-064836
   Rastogi D, 2018, J ALLERGY CLIN IMMUN, V141, P539, DOI 10.1016/j.jaci.2017.04.016
   Rastogi D, 2017, ANN AM THORAC SOC, V14, pS363, DOI [10.1513/AnnalsATS.201703-231AW, 10.1513/annalsats.201703-231aw]
   Rastogi D, 2015, AM J RESP CRIT CARE, V191, P149, DOI 10.1164/rccm.201409-1587OC
   Rosenstock J, 2009, DIABETES TECHNOL THE, V11, P697, DOI 10.1089/dia.2009.0062
   Scott HA, 2013, CLIN EXP ALLERGY, V43, P36, DOI 10.1111/cea.12004
   Sexton P, 2013, J ASTHMA, V50, P75, DOI 10.3109/02770903.2012.740120
   Sheridan PA, 2012, INT J OBESITY, V36, P1072, DOI 10.1038/ijo.2011.208
   Shore SA, 2007, J APPL PHYSIOL, V102, P516, DOI 10.1152/japplphysiol.00847.2006
   Silva RA, 2015, SCAND J MED SCI SPOR, V25, pe258, DOI 10.1111/sms.12311
   Silva RA, 2010, EUR RESPIR J, V35, P994, DOI 10.1183/09031936.00049509
   Singh VP, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0129850
   Stenius-Aarniala B, 2000, BRIT MED J, V320, P827, DOI 10.1136/bmj.320.7238.827
   Thorburn AN, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8320
   Toennesen LL, 2018, J ALLER CL IMM-PRACT, V6, P803, DOI 10.1016/j.jaip.2017.09.028
   Trompette A, 2014, NAT MED, V20, P159, DOI 10.1038/nm.3444
   Türk Y, 2017, J CARDIOPULM REHABIL, V37, P214, DOI 10.1097/HCR.0000000000000249
   Turner S, 2011, RESPIRATION, V81, P302, DOI 10.1159/000315142
   Vieira RP, 2007, AM J RESP CRIT CARE, V176, P871, DOI 10.1164/rccm.200610-1567OC
   Winnica D, 2017, CLIN EXP ALLERGY, V47, P190, DOI 10.1111/cea.12802
   Wood LG, 2012, AM J CLIN NUTR, V96, P534, DOI 10.3945/ajcn.111.032623
   Wood LG, 2011, J ALLERGY CLIN IMMUN, V127, P1133, DOI 10.1016/j.jaci.2011.01.036
   Zhou Y, 2015, CLIN INFECT DIS, V60, pE49, DOI 10.1093/cid/civ060
NR 77
TC 32
Z9 34
U1 1
U2 25
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0272-5231
EI 1557-8216
J9 CLIN CHEST MED
JI Clin. Chest Med.
PD MAR
PY 2019
VL 40
IS 1
BP 97
EP +
DI 10.1016/j.ccm.2018.10.007
PG 11
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA HO3WQ
UT WOS:000460854100009
PM 30691720
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kawashima, M
AF Kawashima, Motoko
TI Systemic Health and Dry Eye
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Article
DE dry eye; systemic health; metabolic syndrome
ID INCREASES TEAR SECRETION; RISK-FACTORS; CALORIE RESTRICTION; METABOLIC
   SYNDROME; OXIDATIVE STRESS; DIETARY SUPPLEMENTATION; NATIONAL-HEALTH;
   OFFICE WORKERS; FISH-OIL; DISEASE
AB Dry eye disease (DED) is a local ocular surface disease caused by a multitude of factors and involves multiple interacting mechanisms. The prevalence of DED is rapidly increasing in the modern aged society, and it is considered a major ocular condition with a high prevalence among the elderly, who frequently have multiple comorbidities. Systemic medical conditions can have a negative impact on ocular health. In addition, a variety of systemic drugs can also induce DED via multiple mechanisms. The adequate management of general systemic diseases may control DED progression. Furthermore, according to the antiaging theory, an appropriate lifestyle intervention is preventive for both DED and general systemic disease. In this article, we focus on systemic health and DED to provide a broad overview of the association between systemic health, particularly in relation to aging, and DED. Ophthalmologists should carefully interview patients with DED regarding systemic comorbidities to deliver optimal treatment. A systemic approach, including the use of supplements and lifestyle intervention, should be used in addition to conventional local treatment.
C1 [Kawashima, Motoko] Keio Univ, Sch Med, Dept Ophthalmol, Tokyo, Japan.
C3 Keio University
RP Kawashima, M (corresponding author), Keio Univ, Sch Med, Dept Ophthalmol, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan.
EM motoko-k@a3.keio.jp
FU Dry Eye Society, Tokyo, Japan
FX Funding of the publication fee and administration was provided by the
   Dry Eye Society, Tokyo, Japan. The Dry Eye Society had no role in the
   contents or writing of the manuscript.
CR Ahn JM, 2014, AM J OPHTHALMOL, V158, P1205, DOI 10.1016/j.ajo.2014.08.021
   Blagosklonny MV, 2007, DRUG DISCOV TODAY, V12, P218, DOI 10.1016/j.drudis.2007.01.004
   Bordone L, 2005, NAT REV MOL CELL BIO, V6, P298, DOI 10.1038/nrm1616
   Cabuk KS, 2016, SAUDI MED J, V37, P1334, DOI 10.15537/smj.2016.12.15623
   Erdur SK, 2017, CURR EYE RES, V42, P1115, DOI 10.1080/02713683.2017.1280511
   Ferrero A, 2018, OCUL SURF, V16, P112, DOI 10.1016/j.jtos.2017.09.008
   Fontana L, 2008, AGING CELL, V7, P681, DOI 10.1111/j.1474-9726.2008.00417.x
   Gomes JAP, 2017, OCUL SURF, V15, P511, DOI 10.1016/j.jtos.2017.05.004
   Hamilton MT, 2007, DIABETES, V56, P2655, DOI 10.2337/db07-0882
   Healy GN, 2008, DIABETES CARE, V31, P661, DOI 10.2337/dc07-2046
   Heilbronn LK, 2006, JAMA-J AM MED ASSOC, V295, P1539, DOI 10.1001/jama.295.13.1539
   HOROWITZ L, 1992, CRANIO, V10, P43, DOI 10.1080/08869634.1992.11677890
   Hush JM, 2006, BMC MUSCULOSKEL DIS, V7, DOI 10.1186/1471-2474-7-81
   Kadowaki T, 2006, INT J OBESITY, V30, P1163, DOI 10.1038/sj.ijo.0803248
   Kawakita T, 2013, BIOMED RES-TOKYO, V34, P215, DOI 10.2220/biomedres.34.215
   Kawashima M, 2018, J OCCUP HEALTH, V60, P281, DOI 10.1539/joh.2017-0191-OA
   Kawashima M, 2016, CLIN OPHTHALMOL, V10, P1015, DOI 10.2147/OPTH.S99620
   Kawashima M, 2016, OCUL SURF, V14, P255, DOI 10.1016/j.jtos.2015.12.005
   Kawashima M, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0123299
   Kawashima M, 2014, J OPHTHALMOL, V2014, DOI 10.1155/2014/943786
   Kawashima M, 2014, BRIT J OPHTHALMOL, V98, P418, DOI 10.1136/bjophthalmol-2013-303953
   Kawashima M, 2013, EXP GERONTOL, V48, P1096, DOI 10.1016/j.exger.2013.04.002
   Kawashima M, 2010, BIOCHEM BIOPH RES CO, V397, P724, DOI 10.1016/j.bbrc.2010.06.018
   Kohl HW, 2012, LANCET, V380, P294, DOI 10.1016/S0140-6736(12)60898-8
   Kojima T, 2012, AM J PATHOL, V180, P1879, DOI 10.1016/j.ajpath.2012.01.019
   Lee AJ, 2002, BRIT J OPHTHALMOL, V86, P1347, DOI 10.1136/bjo.86.12.1347
   Nakamura S, 2007, INVEST OPHTH VIS SCI, V48, P1552, DOI 10.1167/iovs.06-1027
   Owen N, 2009, BRIT J SPORT MED, V43, P81, DOI 10.1136/bjsm.2008.055269
   Pal GK, 2004, INDIAN J MED RES, V120, P115
   Paulsen AJ, 2014, AM J OPHTHALMOL, V157, P799, DOI 10.1016/j.ajo.2013.12.023
   Roh HC, 2016, CORNEA, V35, P187, DOI 10.1097/ICO.0000000000000657
   Sano K, 2018, CLIN OPHTHALMOL, V12, P307, DOI 10.2147/OPTH.S149986
   Sano K, 2015, OCUL SURF, V13, P82, DOI 10.1016/j.jtos.2014.08.002
   Sano K, 2014, INVEST OPHTH VIS SCI, V55, P4287, DOI 10.1167/iovs.13-13289
   Schaumberg DA, 2009, ARCH OPHTHALMOL-CHIC, V127, P763, DOI 10.1001/archophthalmol.2009.103
   Sjögren T, 2005, PAIN, V116, P119, DOI 10.1016/j.pain.2005.03.031
   Spindler SR, 2001, ANN NY ACAD SCI, V928, P296
   Stapleton F, 2017, OCUL SURF, V15, P334, DOI 10.1016/j.jtos.2017.05.003
   Tan LL, 2015, CLIN EXP OPTOM, V98, P45, DOI 10.1111/cxo.12210
   TANAKA T, 1989, ERGONOMICS, V32, P1595, DOI 10.1080/00140138908966928
   Tang YL, 2016, INT J OPHTHALMOL-CHI, V9, P1038, DOI 10.18240/ijo.2016.07.17
   Tsubota K, 2010, OPHTHALMIC RES, V44, P146, DOI 10.1159/000316594
   Uchino M, 2006, OPTOMETRY VISION SCI, V83, P797, DOI 10.1097/01.opx.0000232814.39651.fa
   Uchino M, 2011, OPHTHALMOLOGY, V118, P2361, DOI 10.1016/j.ophtha.2011.05.029
   Uchino Y, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0045805
   Wakamatsu TH, 2008, ARQ BRAS OFTALMOL, V71, P72, DOI 10.1590/S0004-27492008000700015
   Wang TJ, 2012, ACTA OPHTHALMOL, V90, P663, DOI 10.1111/j.1755-3768.2010.01993.x
   Yang WJ, 2015, OPTOMETRY VISION SCI, V92, pE199, DOI 10.1097/OPX.0000000000000541
NR 48
TC 22
Z9 23
U1 2
U2 9
PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC
PI ROCKVILLE
PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA
SN 0146-0404
EI 1552-5783
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD NOV
PY 2018
VL 59
IS 14
SI SI
DI 10.1167/iovs.17-23765
PG 5
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA HC6NV
UT WOS:000451919400021
PM 30481818
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Reid, DT
   Eksteen, B
AF Reid, D. T.
   Eksteen, B.
TI Murine models provide insight to the development of non-alcoholic fatty
   liver disease
SO NUTRITION RESEARCH REVIEWS
LA English
DT Review
DE Obesity; Non-alcoholic fatty liver; Non-alcoholic steatohepatitis;
   Animal models
ID DIET-INDUCED OBESITY; RECEPTOR KNOCKOUT MICE; HEPATIC STEATOSIS;
   INSULIN-RESISTANCE; MOUSE MODEL; METABOLIC SYNDROME; DB/DB MICE;
   HEPATOCELLULAR-CARCINOMA; PARENTERAL-NUTRITION; ANIMAL-MODEL
AB Associated with the obesity epidemic, non-alcoholic fatty liver disease (NAFLD) has become the leading liver disease in North America. Approximately 30 % of patients with NAFLD may develop non-alcoholic steatohepatitis (NASH) that can lead to cirrhosis and hepatocellular carcinoma (HCC). Frequently animal models are used to help identify underlying factors contributing to NAFLD including insulin resistance, dysregulated lipid metabolism and mitochondrial stress. However, studying the inflammatory, progressive nature of NASH in the context of obesity has proven to be a challenge in mice. Although the development of effective treatment strategies for NAFLD and NASH is gaining momentum, the field is hindered by a lack of a concise animal model that reflects the development of liver disease during obesity and the metabolic syndrome. Therefore, selecting an animal model to study NAFLD or NASH must be done carefully to ensure the optimal application. The most widely used animal models have been reviewed highlighting their advantages and disadvantages to studying NAFLD and NASH specifically in the context of obesity.
C1 [Reid, D. T.; Eksteen, B.] Univ Calgary, Cumming Sch Med, Snyder Inst Chron Dis, Calgary, AB, Canada.
C3 University of Calgary
RP Eksteen, B (corresponding author), Univ Calgary, Cumming Sch Med, Snyder Inst Chron Dis, Calgary, AB, Canada.
EM b.eksteen@ucalgary.ca
FU Natural Sciences and Engineering Research Council of Canada (NSERC);
   Canadian Institutes of Health Research (CIHR) Signature Initiative Team
   grant
FX The present review was supported by a Natural Sciences and Engineering
   Research Council of Canada (NSERC) fellowship (to D. T. R.) and a
   Canadian Institutes of Health Research (CIHR) Signature Initiative Team
   grant (to B. E.).
CR Alexander J, 2013, J GASTROEN HEPATOL, V28, P848, DOI 10.1111/jgh.12116
   Arsov T, 2006, MOL ENDOCRINOL, V20, P1610, DOI 10.1210/me.2005-0494
   Bellafante E, 2013, HEPATOLOGY, V57, P1343, DOI 10.1002/hep.26222
   Bellentani S, 2001, J HEPATOL, V35, P531, DOI 10.1016/S0168-8278(01)00151-9
   Bojic LA, 2014, ARTERIOSCL THROM VAS, V34, P52, DOI 10.1161/ATVBAHA.113.301830
   Boyle JP, 2010, POPUL HEALTH METR, V8, DOI 10.1186/1478-7954-8-29
   Brainard RE, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0083174
   Brown ML, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0099656
   Buchman AL, 2001, JPEN-PARENTER ENTER, V25, P260, DOI 10.1177/0148607101025005260
   Buchman AL, 2009, GASTROENTEROLOGY, V137, pS119, DOI 10.1053/j.gastro.2009.08.010
   Bugianesi E, 2010, CURR PHARM DESIGN, V16, P1941, DOI 10.2174/138161210791208875
   Caballero B, 2007, EPIDEMIOL REV, V29, P1, DOI 10.1093/epirev/mxm012
   Carpéné C, 2014, EUR J NUTR, V53, P1625, DOI 10.1007/s00394-014-0668-1
   Carpenter KC, 2013, LAB ANIM-UK, V47, P266, DOI 10.1177/0023677213501658
   Charlton M, 2011, AM J PHYSIOL-GASTR L, V301, pG825, DOI 10.1152/ajpgi.00145.2011
   Clemmensen C, 2013, J ENDOCRINOL, V217, P151, DOI 10.1530/JOE-12-0550
   Corbin JA, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0088684
   Coulon S, 2013, HEPATOLOGY, V57, P1793, DOI 10.1002/hep.26219
   d Oliveira RB, 2014, INT J EXP PATHOL, V95, P296, DOI 10.1111/iep.12084
   Das SK, 2011, INDIAN J CLIN BIOCHE, V26, P202, DOI 10.1007/s12291-011-0121-7
   Day CP, 1998, HEPATOLOGY, V27, P1463, DOI 10.1002/hep.510270601
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   Depner CM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0083756
   Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI23621
   Engl J, 2008, EUR J CLIN INVEST, V38, P238, DOI 10.1111/j.1365-2362.2008.01929.x
   Farrell GC, 2012, GUT LIVER, V6, P149, DOI 10.5009/gnl.2012.6.2.149
   Fujii H, 2012, J GASTROENTEROL, V47, P215, DOI 10.1007/s00535-012-0527-x
   Fujii H, 2009, J GASTROENTEROL, V44, P608, DOI 10.1007/s00535-009-0046-6
   Galloway CA, 2014, AM J PHYSIOL-GASTR L, V307, pG632, DOI 10.1152/ajpgi.00182.2014
   Hamaguchi M, 2012, WORLD J GASTROENTERO, V18, P1508, DOI 10.3748/wjg.v18.i13.1508
   Handa P, 2014, HEPATOLOGY, V60, P133, DOI 10.1002/hep.26946
   Heiker JT, 2014, PHYSIOL GENOMICS, V46, P377, DOI 10.1152/physiolgenomics.00014.2014
   Heinrichs D, 2014, FASEB J, V28, P5136, DOI 10.1096/fj.14-256776
   Hennig EE, 2014, J CELL MOL MED, V18, P1762, DOI 10.1111/jcmm.12328
   Hirsova P, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0070599
   Hodgson K, 2013, ENDOCRINE, V43, P447, DOI 10.1007/s12020-013-9874-5
   Jitnarin N, 2014, SAF HEALTH WORK, V5, P161
   Jorgensen BP, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0103398
   Kanuri G, 2015, EUR J NUTR
   Kawada N, 2009, J GASTROENTEROL, V44, P1190, DOI 10.1007/s00535-009-0112-0
   Kim KH, 2013, NAT MED, V19, P83, DOI 10.1038/nm.3014
   Kong M, 2014, AM J PHYSIOL-GASTR L, V307, pG883, DOI 10.1152/ajpgi.00427.2013
   Kwanten WJ, 2014, WORLD J GASTROENTERO, V20, P7325, DOI 10.3748/wjg.v20.i23.7325
   Lafarge JC, 2014, DIABETOLOGIA, V57, P1674, DOI 10.1007/s00125-014-3280-2
   Larrain S, 2012, CLIN LIVER DIS, V16, P525, DOI 10.1016/j.cld.2012.05.009
   Larter CZ, 2013, OBESITY, V21, P1189, DOI 10.1002/oby.20123
   Levene AP, 2012, HISTOPATHOLOGY, V61, P141, DOI 10.1111/j.1365-2559.2011.04145.x
   Lottenberg AM, 2012, J NUTR BIOCHEM, V23, P1027, DOI 10.1016/j.jnutbio.2012.03.004
   LUDWIG J, 1980, MAYO CLIN PROC, V55, P434
   Machado MV, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0127991
   Matsumoto M, 2013, INT J EXP PATHOL, V94, P93, DOI 10.1111/iep.12008
   Matsuzawa N, 2007, HEPATOLOGY, V46, P1392, DOI 10.1002/hep.21874
   Michelotti GA, 2013, NAT REV GASTRO HEPAT, V10, P656, DOI 10.1038/nrgastro.2013.183
   Milic S, 2012, DIGEST DIS, V30, P158, DOI 10.1159/000336669
   Montgomery MK, 2013, DIABETOLOGIA, V56, P1129, DOI 10.1007/s00125-013-2846-8
   Musso G, 2013, PROG LIPID RES, V52, P175, DOI 10.1016/j.plipres.2012.11.002
   Nagao M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0084725
   Nagarajan P, 2012, WORLD J GASTROENTERO, V18, P1141, DOI 10.3748/wjg.v18.i11.1141
   Nettschwander-Tetri BA, 2010, HEPATOLOGY, V52, P913, DOI 10.1002/hep.23784
   Nigam P, 2013, DIABETES METAB SYND, V7, P72, DOI 10.1016/j.dsx.2013.02.031
   Noyan-Ashraf MH, 2013, CIRCULATION, V127, P74, DOI 10.1161/CIRCULATIONAHA.112.091215
   Oliveira MC, 2013, OBESITY, V21, pE396, DOI [10.1038/oby.20230, 10.1002/oby.20230]
   Omar B, 2012, NUTRIENTS, V4, P1367, DOI 10.3390/nu4101367
   Ouyang SD, 2014, J CEREBR BLOOD F MET, V34, P43, DOI 10.1038/jcbfm.2013.166
   Pacana T, 2012, CLIN LIVER DIS, V16, P599, DOI 10.1016/j.cld.2012.05.008
   Pagadala MR, 2012, CLIN LIVER DIS, V16, P487, DOI 10.1016/j.cld.2012.05.006
   Pérez-Martínez L, 2014, J ANTIMICROB CHEMOTH, V69, P1903, DOI 10.1093/jac/dku071
   Petta S, 2015, ALIMENT PHARM THER, V41, P939, DOI 10.1111/apt.13169
   Podrini C, 2013, MAMM GENOME, V24, P240, DOI 10.1007/s00335-013-9456-0
   Rahimi RS, 2013, NUTR CLIN PRACT, V28, P40, DOI 10.1177/0884533612470464
   Rezaianzadeh A, 2012, INT J PREVENTIVE MED, V3, P552
   Richmond TK, 2015, INT J OBESITY, V39, P546, DOI 10.1038/ijo.2014.147
   Rinella ME, 2008, J LIPID RES, V49, P1068, DOI 10.1194/jlr.M800042-JLR200
   Ritze Y, 2014, BRIT J NUTR, V112, P1, DOI 10.1017/S0007114514000440
   Sahai A, 2004, AM J PHYSIOL-GASTR L, V287, pG1035, DOI 10.1152/ajpgi.00199.2004
   Salamone F, 2012, DIGEST LIVER DIS, V44, P334, DOI 10.1016/j.dld.2011.11.010
   Savard C, 2013, HEPATOLOGY, V57, P81, DOI 10.1002/hep.25789
   Sims EK, 2013, AM J PHYSIOL-ENDOC M, V305, pE1495, DOI 10.1152/ajpendo.00366.2013
   Spruss A, 2012, MOL MED, V18, P1346, DOI 10.2119/molmed.2012.00223
   Streba LAM, 2015, WORLD J GASTROENTERO, V21, P4103, DOI 10.3748/wjg.v21.i14.4103
   Subramanian S, 2011, J LIPID RES, V52, P1626, DOI 10.1194/jlr.M016246
   Tamura Y, 2008, ARTERIOSCL THROM VAS, V28, P2195, DOI 10.1161/ATVBAHA.108.168633
   Tan JTM, 2013, AM J PHYSIOL-ENDOC M, V304, pE1291, DOI 10.1152/ajpendo.00654.2012
   Tetri LH, 2008, AM J PHYSIOL-GASTR L, V295, pG987, DOI 10.1152/ajpgi.90272.2008
   Tilg H, 2008, TRENDS ENDOCRIN MET, V19, P371, DOI 10.1016/j.tem.2008.08.005
   Torres DM, 2012, SEMIN LIVER DIS, V32, P30, DOI 10.1055/s-0032-1306424
   Trak-Smayra V, 2011, INT J EXP PATHOL, V92, P413, DOI 10.1111/j.1365-2613.2011.00793.x
   Tuyama AC, 2012, J DIABETES, V4, P266, DOI 10.1111/j.1753-0407.2012.00204.x
   van Rooyen DM, 2011, GASTROENTEROLOGY, V141, P1393, DOI 10.1053/j.gastro.2011.06.040
   Volynets V, 2012, DIGEST DIS SCI, V57, P1932, DOI 10.1007/s10620-012-2112-9
   Waller-Evans H, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0082825
   Weitman ES, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0070703
   Weltman MD, 1996, GASTROENTEROLOGY, V111, P1645, DOI 10.1016/S0016-5085(96)70028-8
   Wieckowska A, 2008, SEMIN LIVER DIS, V28, P386, DOI 10.1055/s-0028-1091983
   Xu LY, 2013, MOL PHARMACOL, V83, P648, DOI 10.1124/mol.112.081505
   Yang YB, 2014, OBESITY, V22, P2147, DOI 10.1002/oby.20811
   Yang ZH, 2012, DIABETOL METAB SYNDR, V4, DOI 10.1186/1758-5996-4-32
   Yasui K, 2011, CLIN GASTROENTEROL H, V9, P428, DOI 10.1016/j.cgh.2011.01.023
NR 98
TC 23
Z9 25
U1 1
U2 34
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0954-4224
EI 1475-2700
J9 NUTR RES REV
JI Nutr. Res. Rev.
PD DEC
PY 2015
VL 28
IS 2
BP 133
EP 142
DI 10.1017/S0954422415000128
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CY8LH
UT WOS:000366659400004
PM 26494024
OA Bronze
DA 2025-06-11
ER

PT J
AU Huneault, HE
   Tovar, AR
   Sanchez-Torres, C
   Welsh, JA
   Vos, MB
AF Huneault, Helaina E.
   Tovar, Ana Ramirez
   Sanchez-Torres, Cristian
   Welsh, Jean A.
   Vos, Miriam B.
TI The Impact and Burden of Dietary Sugars on the Liver
SO HEPATOLOGY COMMUNICATIONS
LA English
DT Review
ID DE-NOVO LIPOGENESIS; MUSCLE INSULIN-RESISTANCE; FATTY LIVER; HEPATIC
   STEATOSIS; UNITED-STATES; FRUCTOSE RESTRICTION; METABOLIC SYNDROME;
   GENETIC-VARIATION; OXIDATIVE STRESS; LIPID DROPLETS
AB NAFLD, or metabolic dysfunction-associated steatotic liver disease, has increased in prevalence hand in hand with the rise in obesity and increased free sugars in the food supply. The causes of NAFLD are genetic in origin combined with environmental drivers of the disease phenotype. Dietary intake of added sugars has been shown to have a major role in the phenotypic onset and progression of the disease. Simple sugars are key drivers of steatosis, likely through fueling de novo lipogenesis, the conversion of excess carbohydrates into fatty acids, but also appear to upregulate lipogenic metabolism and trigger hyperinsulinemia, another driver. NAFLD carries a clinical burden as it is associated with obesity, type 2 diabetes, metabolic syndrome, and cardiovascular disease. Patient quality of life is also impacted, and there is an enormous economic burden due to healthcare use, which is likely to increase in the coming years. This review aims to discuss the role of dietary sugar in NAFLD pathogenesis, the health and economic burden, and the promising potential of sugar reduction to improve health outcomes for patients with this chronic liver disease.
C1 [Huneault, Helaina E.; Welsh, Jean A.; Vos, Miriam B.] Emory Univ, Laney Grad Sch, Nutr & Hlth Sci Program, Atlanta, GA USA.
   [Tovar, Ana Ramirez; Sanchez-Torres, Cristian; Welsh, Jean A.; Vos, Miriam B.] Emory Univ, Dept Pediat, Div Gastroenterol Hepatol & Nutr, Atlanta, GA USA.
   [Vos, Miriam B.] 1760 Haygood Dr, Atlanta, GA 30030 USA.
C3 Emory University; Emory University
RP Vos, MB (corresponding author), 1760 Haygood Dr, Atlanta, GA 30030 USA.
EM hhuneau@emory.edu; ana.maria.ramirez.tovar@emory.edu;
   cristian.julian.sanchez-torres@emory.edu; jwelsh1@emory.edu;
   mvos@emory.edu
OI Sanchez-Torres, Cristian/0000-0002-0314-5438; Welsh,
   Jean/0000-0002-1372-5524; Ramirez Tovar, Ana/0000-0002-9038-6589;
   Huneault, Helaina/0000-0003-3866-2387
FU National Institutes of Health (NIH) [R01NR019083, R01DK125701]
FX Supported by the National Institutes of Health (NIH) (grant numbers
   R01NR019083 and R01DK125701)
CR Adejumo AC, 2019, ANN GASTROENTEROL, V32, P504, DOI 10.20524/aog.2019.0402
   Ahmed SH, 2013, CURR OPIN CLIN NUTR, V16, P434, DOI 10.1097/MCO.0b013e328361c8b8
   Allen AM, 2023, J HEPATOL, V79, P209, DOI 10.1016/j.jhep.2023.01.026
   Colchero MA, 2016, BMJ-BRIT MED J, V352, DOI 10.1136/bmj.h6704
   Arrese M, 2021, SEMIN LIVER DIS, V41, P421, DOI 10.1055/s-0041-1730927
   Arrese M, 2016, DIGEST DIS SCI, V61, P1294, DOI 10.1007/s10620-016-4049-x
   Avena NM, 2008, NEUROSCI BIOBEHAV R, V32, P20, DOI 10.1016/j.neubiorev.2007.04.019
   Baffy G, 2009, J HEPATOL, V51, P212, DOI 10.1016/j.jhep.2009.03.008
   Baker P, 2020, OBES REV, V21, DOI 10.1111/obr.13126
   Ballestri S, 2016, J GASTROEN HEPATOL, V31, P936, DOI 10.1111/jgh.13264
   BasuRay S, 2019, P NATL ACAD SCI USA, V116, P9521, DOI 10.1073/pnas.1901974116
   BasuRay S, 2017, HEPATOLOGY, V66, P1111, DOI 10.1002/hep.29273
   Beauchamp GK, 2016, PHYSIOL BEHAV, V164, P432, DOI 10.1016/j.physbeh.2016.05.007
   Beisner J, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113444
   Best C. H., 1949, British Medical Journal, V2, P1001
   Brown MS, 2008, CELL METAB, V7, P95, DOI 10.1016/j.cmet.2007.12.009
   Carrillo-Larco RM, 2022, BMJ OPEN, V12, DOI 10.1136/bmjopen-2022-067203
   Celis-Morales C, 2017, INT J EPIDEMIOL, V46, P578, DOI 10.1093/ije/dyw186
   Chen HW, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16122192
   Chen Z, 2020, FREE RADICAL BIO MED, V152, P116, DOI 10.1016/j.freeradbiomed.2020.02.025
   Choi YJ, 2014, LAB INVEST, V94, P1114, DOI 10.1038/labinvest.2014.98
   Cohen CC, 2023, METABOLITES, V13, DOI 10.3390/metabo13030401
   Cohen CC, 2021, J CLIN INVEST, V131, DOI 10.1172/JCI150996
   Davis JN, 2010, AM J CLIN NUTR, V92, P1522, DOI 10.3945/ajcn.2010.30185
   DDDDBerciano S., 2022, Front Nutri, V98, P913
   De Cosmi V, 2017, NUTRIENTS, V9, DOI 10.3390/nu9020107
   de Toro-Martín J, 2017, NUTRIENTS, V9, DOI 10.3390/nu9080913
   DGfA, 2023, Make Every Bite Count With the Dietary Guidelines
   DiNicolantonio JJ, 2018, BRIT J SPORT MED, V52, P910, DOI 10.1136/bjsports-2017-097971
   Do MH, 2018, NUTRIENTS, V10, DOI 10.3390/nu10060761
   Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI23621
   Douard V, 2013, J PHYSIOL-LONDON, V591, P401, DOI 10.1113/jphysiol.2011.215731
   Draijer L, 2019, EXPERT REV GASTROENT, V13, P447, DOI 10.1080/17474124.2019.1595589
   Drewnowski A, 2012, J NUTR, V142, p1142S, DOI 10.3945/jn.111.149575
   Erlanson-Albertsson C, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22179562
   Esteban JPG, 2022, TRANSL GASTROENT HEP, V7, DOI 10.21037/tgh.2020.03.04
   Fabbrini E, 2008, GASTROENTEROLOGY, V134, P424, DOI 10.1053/j.gastro.2007.11.038
   Fabbrini E, 2016, GASTROENTEROLOGY, V150, P79, DOI 10.1053/j.gastro.2015.09.003
   Falbe J, 2016, AM J PUBLIC HEALTH, V106, P1865, DOI 10.2105/AJPH.2016.303362
   Federico A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13041314
   Ferraris RP, 2018, ANNU REV NUTR, V38, P41, DOI 10.1146/annurev-nutr-082117-051707
   Ferré P, 2010, DIABETES OBES METAB, V12, P83, DOI 10.1111/j.1463-1326.2010.01275.x
   Flannery C, 2012, DIABETES, V61, P2711, DOI 10.2337/db12-0206
   FREUDENBERG M A, 1990, International Reviews of Immunology, V6, P207, DOI 10.3109/08830189009056632
   Geidl-Flueck B, 2021, J HEPATOL, V75, DOI 10.1016/j.jhep.2021.02.027
   Geng YN, 2021, HEPATOL INT, V15, P21, DOI 10.1007/s12072-020-10121-2
   Glass Lisa M, 2019, Fed Pract, V36, P64
   Goyal NP, 2018, CLIN LIVER DIS, V22, P59, DOI 10.1016/j.cld.2017.08.002
   Gronboek H, 2012, J PEDIATR GASTR NUTR, V54, P223, DOI 10.1097/MPG.0b013e31822cdedf
   Harte AL, 2010, J INFLAMM-LOND, V7, DOI 10.1186/1476-9255-7-15
   Hrncir T, 2021, MICROORGANISMS, V9, DOI 10.3390/microorganisms9050957
   Huh Y, 2022, J OBES METAB SYNDR, V31, P17, DOI 10.7570/jomes22021
   Imamura F, 2015, BMJ-BRIT MED J, V351, DOI 10.1136/bmj.h3576
   Ipsen DH, 2018, CELL MOL LIFE SCI, V75, P3313, DOI 10.1007/s00018-018-2860-6
   Jang C, 2018, CELL METAB, V27, P351, DOI 10.1016/j.cmet.2017.12.016
   Jensen T, 2018, J HEPATOL, V68, P1063, DOI 10.1016/j.jhep.2018.01.019
   Jin ES, 2013, J BIOL CHEM, V288, P14488, DOI 10.1074/jbc.M113.461947
   Jin R, 2014, INT J HEPATOL, V2014, DOI 10.1155/2014/560620
   Kargulewicz A, 2014, PRZ GASTROENTEROL, V9, P18, DOI 10.5114/pg.2014.40845
   Khan S, 2020, SCI TRANSL MED, V12, DOI 10.1126/scitranslmed.aay6218
   Khodami B, 2022, EUR J CLIN NUTR, V76, P987, DOI 10.1038/s41430-022-01081-x
   KOIVISTOINEN P, 1985, INT DENT J, V35, P175
   Konishi K, 2020, ATHEROSCLEROSIS, V299, P32, DOI 10.1016/j.atherosclerosis.2020.02.026
   Koot BGP, 2016, INT J OBESITY, V40, P51, DOI 10.1038/ijo.2015.175
   Kord-Varkaneh H, 2023, NUTRITION, V105, DOI 10.1016/j.nut.2022.111847
   Lambert JE, 2014, GASTROENTEROLOGY, V146, P726, DOI 10.1053/j.gastro.2013.11.049
   Lanaspa MA, 2012, J BIOL CHEM, V287, P40732, DOI 10.1074/jbc.M112.399899
   Lassailly G, 2016, GASTROENTEROLOGY, V150, P1835, DOI 10.1053/j.gastro.2016.03.004
   Lazo M, 2013, AM J EPIDEMIOL, V178, P38, DOI 10.1093/aje/kws448
   Le MH, 2022, CLIN MOL HEPATOL, V28, P841, DOI 10.3350/cmh.2022.0239
   Leung C, 2016, NAT REV GASTRO HEPAT, V13, P412, DOI 10.1038/nrgastro.2016.85
   Li AA, 2020, GUT LIVER, V14, P168, DOI 10.5009/gnl19069
   Lim S, 2021, TRENDS ENDOCRIN MET, V32, P500, DOI 10.1016/j.tem.2021.04.008
   Listenberger LL, 2003, P NATL ACAD SCI USA, V100, P3077, DOI 10.1073/pnas.0630588100
   Liu SY, 2022, APPL HEALTH ECON HEA, V20, P185, DOI 10.1007/s40258-021-00685-x
   Liu Y, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-47687-3
   Lonardo A., 2021, Explor Med, V2, P435
   Lonardo A, 2018, J HEPATOL, V68, P335, DOI 10.1016/j.jhep.2017.09.021
   Lustig RH, 2016, OBESITY, V24, P453, DOI 10.1002/oby.21371
   Lustig RH, 2010, J AM DIET ASSOC, V110, P1307, DOI 10.1016/j.jada.2010.06.008
   MAENPAA PH, 1968, SCIENCE, V161, P1253, DOI 10.1126/science.161.3847.1253
   Maersk M, 2012, AM J CLIN NUTR, V95, P283, DOI 10.3945/ajcn.111.022533
   Mager DR, 2015, JPEN-PARENTER ENTER, V39, P73, DOI 10.1177/0148607113501201
   MATHISON JC, 1979, J IMMUNOL, V123, P2133
   Mayes Peter A., 1993, American Journal of Clinical Nutrition, V58, p754S, DOI 10.1093/ajcn/58.5.754S
   Mennella JA, 2016, REV ENDOCR METAB DIS, V17, P171, DOI 10.1007/s11154-016-9360-5
   Merino B, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010094
   Mohammad Maysara A., 2020, BML Open Gastro, V7, pe000352
   Moore JB, 2019, P NUTR SOC, V78, P290, DOI 10.1017/S0029665119000570
   Mota M, 2016, METABOLISM, V65, P1049, DOI 10.1016/j.metabol.2016.02.014
   Murphy SP, 2003, AM J CLIN NUTR, V78, p827S, DOI 10.1093/ajcn/78.4.827S
   Muthiah MD, 2022, DIABETES OBES METAB, V24, P3, DOI 10.1111/dom.14521
   Mytton OT, 2012, BMJ-BRIT MED J, V344, DOI 10.1136/bmj.e2931
   Nakae J, 2001, J CLIN INVEST, V108, P1359, DOI 10.1172/JCI200112876
   Nobili V, 2006, HEPATOLOGY, V44, P458, DOI 10.1002/hep.21262
   Noureddin M, 2022, HEPATOL COMMUN, V6, P1537, DOI 10.1002/hep4.1935
   Organization WH, 2023, WHO calls on countries to reduce sugars intake among adults and children
   Organization WH, 2020, Guideline: Sugars intake for adults and children
   Paarlberg R, 2017, FOOD POLICY, V71, P1, DOI 10.1016/j.foodpol.2017.05.007
   Pal P, 2021, WORLD J HEPATOL, V13, P1584, DOI 10.4254/wjh.v13.i11.1584
   Palma R, 2022, J CLIN MED, V11, DOI 10.3390/jcm11133649
   Park G, 2021, EXP MOL MED, V53, P809, DOI 10.1038/s12276-021-00614-x
   Petersen KF, 2007, P NATL ACAD SCI USA, V104, P12587, DOI 10.1073/pnas.0705408104
   Pollock NK, 2012, J NUTR, V142, P251, DOI 10.3945/jn.111.150219
   Popkin BM, 2006, AM J CLIN NUTR, V84, P289, DOI 10.1093/ajcn/84.2.289
   Popkin BM, 2016, LANCET DIABETES ENDO, V4, P174, DOI 10.1016/S2213-8587(15)00419-2
   Pozzato C, 2010, J PEDIATR GASTR NUTR, V51, P331, DOI 10.1097/MPG.0b013e3181d70468
   Prevention CfDCa, 2023, Get the Facts: Added Sugars
   Ramon-Krauel M, 2013, CHILD OBES, V9, P252, DOI 10.1089/chi.2013.0022
   Reinehr T, 2009, ARCH DIS CHILD, V94, P437, DOI 10.1136/adc.2008.143594
   Ribeiro A, 2019, HEPATOL COMMUN, V3, P44, DOI 10.1002/hep4.1291
   Ricciuto L, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.687643
   Rinella ME, 2023, HEPATOLOGY, V78, P1966, DOI 10.1097/HEP.0000000000000520
   Rippe JM, 2017, NUTR REV, V75, P18, DOI 10.1093/nutrit/nuw046
   Russell C, 2022, PUBLIC HEALTH NUTR, DOI 10.1017/S1368980022001598
   Samuel VT, 2018, CELL METAB, V27, P22, DOI 10.1016/j.cmet.2017.08.002
   Satokari R, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051348
   SCHAFFNER F, 1986, PROG LIVER DIS, V8, P283
   Schmidt KA, 2022, J NUTR, V152, P1655, DOI 10.1093/jn/nxac046
   Schwarz JM, 2017, GASTROENTEROLOGY, V153, P743, DOI 10.1053/j.gastro.2017.05.043
   Schwarz JM, 2017, J AM OSTEOPATH ASSOC, V117, P520, DOI 10.7556/jaoa.2017.102
   Schwarz JM, 2015, J CLIN ENDOCR METAB, V100, P2434, DOI 10.1210/jc.2014-3678
   Schwimmer JB, 2019, JAMA-J AM MED ASSOC, V321, P256, DOI 10.1001/jama.2018.20579
   Sekizkardes H, 2020, J CLIN INVEST, V130, P3592, DOI 10.1172/JCI135431
   Sevastianova K, 2011, AM J CLIN NUTR, V94, P104, DOI 10.3945/ajcn.111.012369
   Shapiro A, 2008, AM J PHYSIOL-REG I, V295, pR1370, DOI 10.1152/ajpregu.00195.2008
   Shen JY, 2015, J GASTROEN HEPATOL, V30, P139, DOI 10.1111/jgh.12656
   Singh RS., 2017, Plant biotechnology: recent advancements and developments, P189, DOI DOI 10.1007/978-981-10-4732-9_10
   SMITH CM, 1977, CAN J BIOCHEM CELL B, V55, P1237, DOI 10.1139/o77-185
   Smith GI, 2020, J CLIN INVEST, V130, P1453, DOI 10.1172/JCI134165
   Stefan N, 2019, LANCET DIABETES ENDO, V7, P313, DOI 10.1016/S2213-8587(18)30154-2
   Sulaiman SA, 2023, BIOMEDICINES, V11, DOI 10.3390/biomedicines11010106
   Sullivan JS, 2015, PEDIATR OBES, V10, P188, DOI 10.1111/ijpo.238
   Sunny NE, 2011, CELL METAB, V14, P804, DOI 10.1016/j.cmet.2011.11.004
   Tajima R, 2019, NUTRITION, V61, P119, DOI 10.1016/j.nut.2018.10.016
   Tariq R, 2020, J CLIN EXP HEPATOL, V10, P81, DOI 10.1016/j.jceh.2019.07.008
   Teff KL, 2004, J CLIN ENDOCR METAB, V89, P2963, DOI 10.1210/jc.2003-031855
   ter Horst KW, 2021, DIABETES CARE, V44, P489, DOI 10.2337/dc20-1644
   Tuncay C, 2020, CLIN NUTR ESPEN, V38, P61, DOI 10.1016/j.clnesp.2020.04.005
   UoCS Francisco, 2023, Hidden in Plain Sight
   Lujan PV, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051442
   VANDENBERGHE G, 1977, BIOCHEM J, V162, P601, DOI 10.1042/bj1620601
   Vreman RA, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2016-013543
   Wang BH, 2017, ENGINEERING-PRC, V3, P71, DOI 10.1016/J.ENG.2017.01.008
   Welsh JA, 2013, J PEDIATR-US, V162, P496, DOI 10.1016/j.jpeds.2012.08.043
   Welsh JA, 2011, AM J CLIN NUTR, V94, P726, DOI 10.3945/ajcn.111.018366
   Wijarnpreecha K, 2016, QJM-INT J MED, V109, P461, DOI 10.1093/qjmed/hcv172
   Yao ZL, 2016, J IMMUNOL, V197, P2390, DOI 10.4049/jimmunol.1600702
   Younossi Z, 2019, HEPATOLOGY, V69, P2672, DOI 10.1002/hep.30251
   Younossi ZM, 2019, J HEPATOL, V70, P531, DOI 10.1016/j.jhep.2018.10.033
   Younossi ZM, 2019, HEPATOLOGY, V69, P564, DOI 10.1002/hep.30254
   Younossi ZM, 2016, HEPATOLOGY, V64, P1577, DOI 10.1002/hep.28785
   Zelber-Sagi S, 2022, LIVER INT, V42, P1731, DOI 10.1111/liv.15335
   Zhao S, 2020, NATURE, V579, P586, DOI 10.1038/s41586-020-2101-7
NR 154
TC 10
Z9 10
U1 2
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
EI 2471-254X
J9 HEPATOL COMMUN
JI Hepatol. Commun.
PD NOV
PY 2023
VL 7
IS 11
AR e0297
DI 10.1097/HC9.0000000000000297
PG 15
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA X2AQ0
UT WOS:001096535400001
PM 37930128
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nduhirabandi, F
   Maarman, GJ
AF Nduhirabandi, Frederic
   Maarman, Gerald J.
TI Melatonin in Heart Failure: A Promising Therapeutic Strategy?
SO MOLECULES
LA English
DT Review
DE cardiac remodeling; cardioprotection; cardiomyopathy; fibrosis; heart
   failure; hypertension; ischemic heart disease; melatonin; metabolic
   syndrome
ID ISCHEMIA-REPERFUSION INJURY; NOCTURNAL BLOOD-PRESSURE;
   PULMONARY-HYPERTENSION; MYOCARDIAL-INFARCTION; METABOLIC SYNDROME;
   EJECTION FRACTION; RISK-FACTORS; PROTECTS; RATS; ASSOCIATION
AB Heart failure is a multifactorial clinical syndrome characterized by the inability of the heart to pump sufficient blood to the body. Despite recent advances in medical management, poor outcomes in patients with heart failure remain very high. This highlights a need for novel paradigms for effective, preventive and curative strategies. Substantial evidence supports the importance of endogenous melatonin in cardiovascular health and the benefits of melatonin supplementation in various cardiac pathologies and cardiometabolic disorders. Melatonin plays a crucial role in major pathological processes associated with heart failure including ischemic injury, oxidative stress, apoptosis, and cardiac remodeling. In this review, available evidence for the role of melatonin in heart failure is discussed. Current challenges and possible limitations of using melatonin in heart failure are also addressed. While few clinical studies have investigated the role of melatonin in the context of heart failure, current findings from experimental studies support the potential use of melatonin as preventive and adjunctive curative therapy in heart failure.
C1 [Nduhirabandi, Frederic; Maarman, Gerald J.] Univ Cape Town, Fac Hlth Sci, Dept Med, Cardioprotect Grp,HICRA, ZA-7935 Cape Town, South Africa.
C3 University of Cape Town
RP Nduhirabandi, F (corresponding author), Univ Cape Town, Fac Hlth Sci, Dept Med, Cardioprotect Grp,HICRA, ZA-7935 Cape Town, South Africa.
EM frederic.nduhirabandi@uct.ac.za; gmaarman@sun.ac.za
RI Nduhirabandi, Frederic/HTT-5030-2023
OI Maarman, Gerald/0000-0003-3336-5594; Nduhirabandi,
   Frederic/0000-0002-0428-1220
FU South African National Research Foundation (NRF) [99701]; University of
   Cape Town; NRF-Postdoctoral Research Fellowship; European Research
   Council / NRF partnership grant; MDPI
FX This research was funded by the South African National Research
   Foundation (NRF) (99701, FN) and the University of Cape Town. FN
   received an NRF-Postdoctoral Research Fellowship and a European Research
   Council / NRF partnership grant. APC was sponsored by MDPI.
CR Abel ED, 2012, ARTERIOSCL THROM VAS, V32, P2068, DOI 10.1161/ATVBAHA.111.241984
   Acuña-Castroviejo D, 2014, CELL MOL LIFE SCI, V71, P2997, DOI 10.1007/s00018-014-1579-2
   Agostoni C, 2011, EFSA J, V9, DOI 10.2903/j.efsa.2011.2241
   Al-Sarraf IAK, 2018, HORM MOL BIOL CLIN I, V35, DOI 10.1515/hmbci-2018-0016
   Amin AH, 2015, EUR J PHARMACOL, V747, P166, DOI 10.1016/j.ejphar.2014.12.002
   An R, 2016, BASIC RES CARDIOL, V111, DOI 10.1007/s00395-015-0526-1
   Andersen LPH, 2016, CLIN DRUG INVEST, V36, P169, DOI 10.1007/s40261-015-0368-5
   Tenorio FDAM, 2015, REV ASSOC MED BRAS, V61, P269
   Arany Z, 2006, P NATL ACAD SCI USA, V103, P10086, DOI 10.1073/pnas.0603615103
   Asghari MH, 2017, ARCH TOXICOL, V91, DOI 10.1007/s00204-017-2029-3
   Auld F, 2017, SLEEP MED REV, V34, P10, DOI 10.1016/j.smrv.2016.06.005
   Baker J, 2018, CLIN EXP PHARMACOL P, V45, P755, DOI 10.1111/1440-1681.12942
   Brown DA, 2017, NAT REV CARDIOL, V14, P238, DOI 10.1038/nrcardio.2016.203
   Cagnacci A, 2005, AM J HYPERTENS, V18, P1614, DOI 10.1016/j.amjhyper.2005.05.008
   Cao YS, 2017, ONCOTARGET, V8, P92064, DOI 10.18632/oncotarget.20752
   Carracedo Gonzalo, 2017, J Optom, V10, P3, DOI 10.1016/j.optom.2016.03.002
   Chua S, 2016, J PINEAL RES, V61, P438, DOI 10.1111/jpi.12357
   Dai DF, 2012, CARDIOVASC RES, V93, P79, DOI 10.1093/cvr/cvr274
   Dauriz M, 2017, DIABETES CARE, V40, P1597, DOI 10.2337/dc17-0697
   Dave, 1998, J Cardiovasc Pharmacol Ther, V3, P153, DOI 10.1177/107424849800300208
   De Jong KA, 2017, CAN J CARDIOL, V33, P860, DOI 10.1016/j.cjca.2017.03.009
   de Vries LJ, 2017, J CARDIOVASC PHARM, V70, P267, DOI 10.1097/FJC.0000000000000515
   Ding MG, 2018, J PINEAL RES, V65, DOI 10.1111/jpi.12491
   Doenst T, 2013, CIRC RES, V113, P709, DOI 10.1161/CIRCRESAHA.113.300376
   Dominguez-Rodriguez A, 2017, J PINEAL RES, V62, DOI 10.1111/jpi.12374
   Dominguez-Rodriguez A, 2016, INT J CARDIOL, V221, P359, DOI 10.1016/j.ijcard.2016.07.056
   Dominguez-Rodriguez A, 2014, INT J CARDIOL, V174, P415, DOI 10.1016/j.ijcard.2014.04.044
   Dominguez-Rodriguez A, 2012, J PINEAL RES, V53, P319, DOI 10.1111/j.1600-079X.2012.01001.x
   Drobnik J, 2011, J PHYSIOL PHARMACOL, V62, P29
   Dzida G, 2013, ANN AGR ENV MED, V20, P745
   Ekelof SV, 2016, HEART VESSELS, V31, P88, DOI 10.1007/s00380-014-0589-1
   Escames G, 2007, FEBS J, V274, P2135, DOI 10.1111/j.1742-4658.2007.05755.x
   Faerber G, 2011, J THORAC CARDIOV SUR, V141, P492, DOI 10.1016/j.jtcvs.2010.03.029
   Favero G, 2017, AGEING RES REV, V35, P336, DOI 10.1016/j.arr.2016.11.007
   Flood EM, 2006, IEEE ENG MED BIOL, V25, P84, DOI 10.1109/MEMB.2006.1636358
   Follath F, 1999, J CARDIOVASC PHARM, V33, pS31, DOI 10.1097/00005344-199900003-00004
   Fragasso Gabriele, 2016, Card Fail Rev, V2, P8, DOI 10.15420/cfr.2016:5:2
   Galano A, 2018, J PINEAL RES, V65, DOI 10.1111/jpi.12514
   Garakyaraghi M, 2012, J RES MED SCI, V17, pS13
   Garaulet M, 2015, METABOLISM, V64, P1650, DOI 10.1016/j.metabol.2015.08.003
   Garfinkel D, 2011, DIABETES METAB SYNDR, V4, P307, DOI 10.2147/DMSO.S23904
   Genade S, 2008, J PINEAL RES, V45, P449, DOI 10.1111/j.1600-079X.2008.00615.x
   Ghosh G, 2007, J PINEAL RES, V42, P71, DOI 10.1111/j.1600-079X.2006.00386.x
   Girotti L, 2003, ENDOCRINE, V22, P245, DOI 10.1385/ENDO:22:3:245
   Grossman E, 2011, VASC HEALTH RISK MAN, V7, P577, DOI 10.2147/VHRM.S24603
   Gubin Denis G, 2016, Curr Aging Sci, V9, P5
   Gupte AA, 2017, ADV EXP MED BIOL, V982, P113, DOI 10.1007/978-3-319-55330-6_6
   Gürses I, 2014, PATHOL RES PRACT, V210, P863, DOI 10.1016/j.prp.2014.08.006
   Han D, 2016, J PINEAL RES, V60, P178, DOI 10.1111/jpi.12299
   Hardeland R, 2013, INT J MOL SCI, V14, P5817, DOI 10.3390/ijms14035817
   Hardeland R, 2011, PROG NEUROBIOL, V93, P350, DOI 10.1016/j.pneurobio.2010.12.004
   Harpsoe NG, 2015, EUR J CLIN PHARMACOL, V71, P901, DOI 10.1007/s00228-015-1873-4
   Hausenloy DJ, 2017, CARDIOVASC RES, V113, P1418, DOI 10.1093/cvr/cvx137
   Herxheimer A., 2002, Cochrane Database Syst Rev, V2, pCD001520, DOI DOI 10.1002/14651858.CD001520
   Heusch G, 2017, CIRC RES, V120, P1477, DOI 10.1161/CIRCRESAHA.117.310820
   Hu JQ, 2017, J PINEAL RES, V62, DOI 10.1111/jpi.12368
   Hu W, 2016, J PINEAL RES, V60, P121, DOI 10.1111/jpi.12302
   Hung MW, 2013, J PINEAL RES, V55, P247, DOI 10.1111/jpi.12067
   Jiki Z, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00528
   Jin HF, 2014, J PINEAL RES, V57, P442, DOI 10.1111/jpi.12184
   Kemp CD, 2012, CARDIOVASC PATHOL, V21, P365, DOI 10.1016/j.carpath.2011.11.007
   Kennaway DJ, 2017, CRIT REV FOOD SCI, V57, P958, DOI 10.1080/10408398.2014.962686
   Khatibzadeh S, 2013, INT J CARDIOL, V168, P1186, DOI 10.1016/j.ijcard.2012.11.065
   Kimak E, 2014, CURR ISS PHARM MED S, V27, P159, DOI 10.1515/cipms-2015-0007
   Koziróg M, 2011, J PINEAL RES, V50, P261, DOI 10.1111/j.1600-079X.2010.00835.x
   Krenz M, 2004, J AM COLL CARDIOL, V44, P2390, DOI 10.1016/j.jacc.2004.09.044
   Krenz M, 2003, J BIOL CHEM, V278, P17466, DOI 10.1074/jbc.M210804200
   Kruger MJ, 2014, FOOD RES INT, V59, P41, DOI 10.1016/j.foodres.2014.01.046
   Kudová J, 2016, J PINEAL RES, V61, P493, DOI 10.1111/jpi.12366
   Lavie CJ, 2018, LANCET DIABETES ENDO, V6, P678, DOI 10.1016/S2213-8587(18)30143-8
   Liskova Iu V, 2013, Morfologiia, V144, P25
   Lochner A, 2018, J PINEAL RES, V65, DOI 10.1111/jpi.12490
   Lochner Amanda, 2013, Front Biosci (Elite Ed), V5, P305
   Lu Q, 2015, IN VITRO CELL DEV-AN, V51, P353, DOI 10.1007/s11626-014-9844-0
   Lyssenko V, 2009, NAT GENET, V41, P82, DOI 10.1038/ng.288
   Maarman G, 2015, J PINEAL RES, V59, P343, DOI 10.1111/jpi.12263
   Maarman G, 2013, PULM CIRC, V3, P739, DOI 10.1086/674770
   Maarman GJ, 2017, BRIT J PHARMACOL, V174, P497, DOI 10.1111/bph.13721
   McMullan CJ, 2017, HEART, V103, P694, DOI 10.1136/heartjnl-2016-310098
   McMullan CJ, 2013, JAMA-J AM MED ASSOC, V309, P1388, DOI 10.1001/jama.2013.2710
   Miyata S, 2000, CIRC RES, V86, P386, DOI 10.1161/01.RES.86.4.386
   Mukherjee D, 2010, J PINEAL RES, V48, P251, DOI 10.1111/j.1600-079X.2010.00749.x
   Muzrak B, 2004, ACTA HISTOCHEM, V106, P29, DOI 10.1016/j.acthis.2003.10.003
   Nduhirabandi F, 2012, ACTA PHYSIOL, V205, P209, DOI 10.1111/j.1748-1716.2012.02410.x
   Nduhirabandi F, 2017, CARDIOVASC J AFR, V28, P362, DOI 10.5830/CVJA-2017-018
   Nduhirabandi F, 2014, J PINEAL RES, V57, P317, DOI 10.1111/jpi.12171
   Nduhirabandi F, 2011, J PINEAL RES, V50, P171, DOI 10.1111/j.1600-079X.2010.00826.x
   Opie LH, 2006, LANCET, V367, P356, DOI 10.1016/S0140-6736(06)68074-4
   Opie L, 2015, LANCET, V385, P774, DOI 10.1016/S0140-6736(15)60438-X
   Opie LH, 2016, EUR HEART J-CARD PHA, V2, P258, DOI 10.1093/ehjcvp/pvv037
   Pan P, 2018, MOLECULES, V23, DOI 10.3390/molecules23030675
   Pandi-Perumal SR, 2017, J CARDIOVASC PHARM T, V22, P122, DOI 10.1177/1074248416660622
   Patel R, 2018, BIOMED PHARMACOTHER, V103, P429, DOI 10.1016/j.biopha.2018.04.058
   Patel V, 2010, EUR J PHARMACOL, V644, P160, DOI 10.1016/j.ejphar.2010.06.065
   Paulis L, 2012, EXPERT OPIN INV DRUG, V21, P1661, DOI 10.1517/13543784.2012.714771
   Pechanova O, 2014, INT J MOL SCI, V15, P17920, DOI 10.3390/ijms151017920
   Pei HF, 2017, J PINEAL RES, V62, DOI 10.1111/jpi.12371
   Pei HF, 2016, FREE RADICAL BIO MED, V97, P408, DOI 10.1016/j.freeradbiomed.2016.06.015
   Perrone-Filardi P, 2015, EUR HEART J, V36, P2630, DOI 10.1093/eurheartj/ehv350
   Peschke E, 2008, J PINEAL RES, V44, P26, DOI 10.1111/j.1600-079X.2007.00519.x
   Piao L, 2010, J MOL MED, V88, P47, DOI 10.1007/s00109-009-0524-6
   Ponikowski P, 2016, EUR HEART J, V37, P2129, DOI 10.1093/eurheartj/ehw128
   Raygan F, 2019, CLIN NUTR, V38, P191, DOI 10.1016/j.clnu.2017.12.004
   Rechcinski T, 2010, HYPERTENS RES, V33, P56, DOI 10.1038/hr.2009.174
   Reiter RJ, 2005, NUTRITION, V21, P920, DOI 10.1016/j.nut.2005.02.005
   Reiter RJ, 2018, MOLECULES, V23, DOI 10.3390/molecules23020509
   Reiter RJ, 2014, PHYSIOLOGY, V29, P325, DOI 10.1152/physiol.00011.2014
   Reiter RJ, 2012, ANN MED, V44, P564, DOI 10.3109/07853890.2011.586365
   Reiter RJ, 2010, ANN MED, V42, P276, DOI 10.3109/07853890903485748
   Rimbaud S, 2009, PHARMACOL REP, V61, P131, DOI 10.1016/S1734-1140(09)70015-5
   Oliveira LGR, 2013, ACTA TROP, V128, P652, DOI 10.1016/j.actatropica.2013.09.014
   Rosenkranz S, 2016, EUR HEART J, V37, P942, DOI 10.1093/eurheartj/ehv512
   ROSSI MA, 1991, INT J CARDIOL, V31, P133, DOI 10.1016/0167-5273(91)90207-6
   Sahna E, 2003, J PINEAL RES, V35, P257, DOI 10.1034/j.1600-079X.2003.00084.x
   Segura A, 2014, HEART FAIL REV, V19, P173, DOI 10.1007/s10741-012-9365-4
   Sehirli AÖ, 2013, J PINEAL RES, V55, P138, DOI 10.1111/jpi.12054
   Sewerynek E, 2002, NEUROENDOCRINOL LETT, V23, P79
   Simko F, 2014, J PINEAL RES, V57, P177, DOI 10.1111/jpi.12154
   Simko F, 2014, MEDIAT INFLAMM, V2014, DOI 10.1155/2014/703175
   Stacchiotti A, 2017, NUTRIENTS, V9, DOI 10.3390/nu9121323
   Stroethoff M, 2018, ANESTH ANALG, V126, P2112, DOI 10.1213/ANE.0000000000002625
   Sun H, 2016, CURR OPIN LIPIDOL, V27, P408, DOI 10.1097/MOL.0000000000000314
   Suofu Y, 2017, P NATL ACAD SCI USA, V114, pE7997, DOI 10.1073/pnas.1705768114
   Szymanski PZ, 2018, SAMJ S AFR MED J, V108, P94, DOI [10.7196/SAMJ.2018.v108i2.12519, 10.7196/samj.2018.v108i2.12519, 10.7196/SAMJ.2017.v108i2.12519]
   Tomás-Zapico C, 2005, J PINEAL RES, V39, P99, DOI 10.1111/j.1600-079X.2005.00248.x
   Uchinaka A, 2018, ANN NY ACAD SCI, V1421, P73, DOI 10.1111/nyas.13578
   Venegas C, 2012, J PINEAL RES, V52, P217, DOI 10.1111/j.1600-079X.2011.00931.x
   Vlodaver Z., 2017, CONGESTIVE HEART FAI, P59
   Vonk-Noordegraaf A, 2013, J AM COLL CARDIOL, V62, pD22, DOI 10.1016/j.jacc.2013.10.027
   Wang L, 2017, J PINEAL RES, V63, DOI 10.1111/jpi.12429
   Wu Y, 2018, J PEDIAT-BRAZIL, V94, P446, DOI 10.1016/j.jped.2017.06.023
   Yang Y, 2014, J PINEAL RES, V57, P357, DOI 10.1111/jpi.12175
   Yeung HM, 2015, J PINEAL RES, V58, P12, DOI 10.1111/jpi.12190
   Yin ZY, 2015, BBA-MOL BASIS DIS, V1852, P47, DOI 10.1016/j.bbadis.2014.11.003
   Zannad F, 2018, LANCET, V391, P518, DOI 10.1016/S0140-6736(17)32873-8
   Zawilska JB, 2009, PHARMACOL REP, V61, P383, DOI 10.1016/S1734-1140(09)70081-7
   Zhai MG, 2017, J PINEAL RES, V63, DOI 10.1111/jpi.12433
   Zhang M., 2008, Acute Heart Failure, P118, DOI DOI 10.1007/978-1-84628-782-4_12
   Zhang MM, 2017, J PINEAL RES, V63, DOI 10.1111/jpi.12418
   Zhao YC, 2017, J PINEAL RES, V62, DOI 10.1111/jpi.12378
   Zhou H, 2018, CELL SIGNAL, V47, P88, DOI 10.1016/j.cellsig.2018.03.012
   Zhou H, 2018, J PINEAL RES, V64, DOI 10.1111/jpi.12471
   Zhu P, 2015, J CELL MOL MED, V19, P2232, DOI 10.1111/jcmm.12610
   Ziaeian B, 2016, NAT REV CARDIOL, V13, P368, DOI 10.1038/nrcardio.2016.25
NR 144
TC 42
Z9 43
U1 1
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD JUL
PY 2018
VL 23
IS 7
AR 1819
DI 10.3390/molecules23071819
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GU5CE
UT WOS:000445301800322
PM 30037127
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Marcelino, G
   Machate, DJ
   Freitas, KD
   Hiane, PA
   Maldonade, IR
   Pott, A
   Asato, MA
   Candido, CJ
   Guimaraes, RDA
AF Marcelino, Gabriela
   Machate, David Johane
   Freitas, Karine de Cassia
   Hiane, Priscila Aiko
   Maldonade, Iriani Rodrigues
   Pott, Arnildo
   Asato, Marcel Arakaki
   Candido, Camila Jordao
   Avellaneda Guimaraes, Rita de Cassia
TI β-Carotene: Preventive Role for Type 2 Diabetes Mellitus and Obesity: A
   Review
SO MOLECULES
LA English
DT Review
DE oxidative stress; dyslipidemia; antioxidants; insulin resistance
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; SERUM CAROTENOIDS; LOWER
   PREVALENCE; ANTIOXIDANTS; DEGRADATION; CHOLESTEROL; ABSORPTION;
   ADIPOKINES; ADIPOSITY
AB Carotenoids are vital antioxidants for plants and animals. They protect cells from oxidative events and act against the inflammatory process and carcinogenesis. Among the most abundant carotenoids in human and foods is beta-carotene. This carotenoid has the highest level of provitamin A activity, as it splits into two molecules of retinol through the actions of the cytosolic enzymes: beta-carotene-15,15 '-monooxygenase (beta-carotene-15,15 '-oxygenase 1) and beta-carotene-9 ',10 '-dioxygenase (beta-carotene-9 ',10 '-oxygenase 2). The literature supports the idea that beta-carotene acts against type 2 diabetes mellitus, cardiovascular diseases, obesity, and metabolic syndrome. Due to the many processes involved in beta-carotene biosynthesis and metabolic function, little is known about such components, since many mechanisms have not yet been fully elucidated. Therefore, our study concisely described the relationships between the consumption of carotenoids, with emphasis on beta-carotene, and obesity and type 2 diabetes mellitus and its associated parameters in order to understand the preventive role of carotenoids better and encourage their consumption.
C1 [Marcelino, Gabriela; Freitas, Karine de Cassia; Hiane, Priscila Aiko; Candido, Camila Jordao; Avellaneda Guimaraes, Rita de Cassia] Univ Fed Mato Grosso do Sul, Post Grad Program Hlth & Dev Cent West Reg Brazil, BR-79070900 Campo Grande, MS, Brazil.
   [Machate, David Johane] Univ Fed Mato Grosso do Sul, Grad Program Sci Mat, Grp Spect & Bioinformat Appl Biodivers & Hlth GEB, BR-79070900 Campo Grande, MS, Brazil.
   [Maldonade, Iriani Rodrigues] Brazilian Agr Res Corp Embrapa Vegetables, Lab Food Sci & Technol, BR-70275970 Brasilia, DF, Brazil.
   [Pott, Arnildo] Univ Fed Mato Grosso do Sul, Inst Biosci, Lab Bot, BR-79070900 Campo Grande, MS, Brazil.
   [Asato, Marcel Arakaki] Univ Fed Mato Grosso do Sul, Fac Med, BR-79070900 Campo Grande, MS, Brazil.
C3 Universidade Federal de Mato Grosso do Sul; Universidade Federal de Mato
   Grosso do Sul; Empresa Brasileira de Pesquisa Agropecuaria (EMBRAPA);
   Universidade Federal de Mato Grosso do Sul; Universidade Federal de Mato
   Grosso do Sul
RP Freitas, KD (corresponding author), Univ Fed Mato Grosso do Sul, Post Grad Program Hlth & Dev Cent West Reg Brazil, BR-79070900 Campo Grande, MS, Brazil.
EM gabi19ac@gmail.com; machatedavidjohanemachate@yahoo.com.br;
   kcfreitas@gmail.com; priscila.hiane@ufms.br;
   iriani.maldonade@embrapa.br; arnildo.pott@gmail.com;
   marcel_arakakiasato@hotmail.com; cahjordao@gmail.com;
   rita.guimaraes@ufms.br
RI Guimarães, Rita de Cássia/JVO-6281-2024; POTT, ARNILDO/I-5759-2012;
   Johane Machate, David/GPP-1111-2022; Asato, Marcel/AAV-9747-2021;
   Maldonade, Iriani/A-5953-2013
OI Marcelino, Gabriela/0000-0003-0015-6083; Asato,
   Marcel/0000-0002-6050-5292; Maldonade, Iriani/0000-0003-2283-1270
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, Brazil
   (CAPES) [001]
FX This study was financed in part by the Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior, Brazil (CAPES)-Finance Code 001.
CR Abbasian M, 2018, DIABETES METAB SYND, V12, P497, DOI 10.1016/j.dsx.2018.03.015
   Amara N. B., 2015, EUROPEAN J NUTR, V54, P447, DOI DOI 10.1007/s00394-014-0728-6
   Amengual J, 2020, J NUTR, V150, P2023, DOI 10.1093/jn/nxaa143
   Amengual J, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020644
   Asemi Z, 2016, CLIN NUTR, V35, P819, DOI 10.1016/j.clnu.2015.07.009
   Bacchetti T., 2016, Integr. Food Nutr. Metab, V3, P283, DOI [10.15761/IFNM.1000144, DOI 10.15761/IFNM.1000144]
   Beydoun MA, 2019, NUTR REV, V77, P32, DOI 10.1093/nutrit/nuy044
   Blesso CN, 2013, FOOD FUNCT, V4, P213, DOI 10.1039/c2fo30154g
   Bohn T, 2019, J AOAC INT, V102, P1044, DOI 10.5740/jaoacint.19-0015
   Bonet ML, 2020, BBA-MOL CELL BIOL L, V1865, DOI 10.1016/j.bbalip.2020.158676
   Borel P, 2017, NUTRIENTS, V9, DOI 10.3390/nu9030246
   Canas JA, 2017, J CLIN ENDOCR METAB, V102, P1983, DOI 10.1210/jc.2017-00185
   Canas JA, 2012, J PEDIATR-US, V161, P58, DOI 10.1016/j.jpeds.2012.01.030
   Chen JJ, 2017, FOOD HYDROCOLLOID, V69, P49, DOI 10.1016/j.foodhyd.2017.01.024
   Cho SO, 2018, J CANCER PREV, V23, P37, DOI 10.15430/JCP.2018.23.1.37
   Dommermuth R, 2018, PRIMARY CARE, V45, P109, DOI 10.1016/j.pop.2017.10.003
   Eggersdorfer M, 2018, ARCH BIOCHEM BIOPHYS, V652, P18, DOI 10.1016/j.abb.2018.06.001
   Farook VS, 2017, AM J CLIN NUTR, V106, P52, DOI 10.3945/ajcn.116.144006
   Fiedor J, 2014, NUTRIENTS, V6, P466, DOI 10.3390/nu6020466
   Francisqueti FV, 2017, REV ASSOC MED BRAS, V63, P85
   Grune T, 2010, J NUTR, V140, p2268S, DOI 10.3945/jn.109.119024
   Harari A, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061625
   Heymann T, 2015, J AGR FOOD CHEM, V63, P3279, DOI 10.1021/acs.jafc.5b00377
   Higuchi K, 2015, NUTRITION, V31, P975, DOI 10.1016/j.nut.2015.02.015
   Hix LM, 2004, REDOX REP, V9, P181, DOI 10.1179/135100004225005967
   Kim Y, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/8601028
   Kiokias S, 2004, FOOD REV INT, V20, P99, DOI 10.1081/FRI-120037155
   Knockaert G, 2012, FOOD CHEM, V133, P60, DOI 10.1016/j.foodchem.2011.12.066
   Kotake-Nara E, 2011, MAR DRUGS, V9, P1024, DOI 10.3390/md9061024
   Lee W., 2017, KOREAN J FAM PRACT, V7, P161, DOI DOI 10.21215/KJFP.2017.7.2.161
   Li MC, 2019, ENVIRON RES, V178, DOI 10.1016/j.envres.2019.108729
   Lin DR, 2016, MOLECULES, V21, DOI 10.3390/molecules21101374
   Liu J, 2014, BRIT J NUTR, V112, P2041, DOI 10.1017/S000711451400316X
   Bonet ML, 2016, SUBCELL BIOCHEM, V79, P377, DOI 10.1007/978-3-319-39126-7_15
   Bonet ML, 2015, ARCH BIOCHEM BIOPHYS, V572, P112, DOI 10.1016/j.abb.2015.02.022
   Matsumoto M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12082310
   Matsumoto M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061825
   Miyashita K, 2019, NUTR PREVENTION TREA, P459, DOI [10.1016/B978-0-12-816093-0.00032-X, DOI 10.1016/B978-0-12-816093-0.00032-X]
   Moran NE, 2018, ADV NUTR, V9, P465, DOI 10.1093/advances/nmy025
   Mounien L, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071562
   Namitha KK, 2010, CRIT REV FOOD SCI, V50, P728, DOI 10.1080/10408398.2010.499811
   Okechukwu Getrude N., 2019, Jordan Journal of Biological Sciences (JJBS), V12, P283
   Paiva SAR, 1999, J AM COLL NUTR, V18, P426, DOI 10.1080/07315724.1999.10718880
   Palmero P, 2014, FOOD CHEM, V157, P275, DOI 10.1016/j.foodchem.2014.02.055
   Pénicaud C, 2011, FRUITS, V66, P417, DOI 10.1051/fruits/2011058
   Perera CO, 2007, INT J FOOD PROP, V10, P201, DOI 10.1080/10942910601045271
   Ponesakki G., 2019, CAROTENOIDS PROPERTI
   Rodriguez-Amaya DB, 2016, CURR OPIN FOOD SCI, V7, P20, DOI 10.1016/j.cofs.2015.08.004
   Rodriguez-Concepcion M, 2018, PROG LIPID RES, V70, P62, DOI 10.1016/j.plipres.2018.04.004
   Roglic G, 2016, Global report on psoriasis
   Roohbakhsh A, 2017, BIOMED PHARMACOTHER, V91, P31, DOI 10.1016/j.biopha.2017.04.057
   Rühl R, 2016, MOL NUTR FOOD RES, V60, P175, DOI 10.1002/mnfr.201500619
   Saini RK, 2015, FOOD RES INT, V76, P735, DOI 10.1016/j.foodres.2015.07.047
   Sanjeevi N, 2019, J ACAD NUTR DIET, V119, P1340, DOI 10.1016/j.jand.2019.03.009
   She C, 2017, CURR MOL MED, V17, P287, DOI 10.2174/1566524017666171106112131
   Shete V, 2013, NUTRIENTS, V5, P4849, DOI 10.3390/nu5124849
   Sluijs I, 2009, J NUTR, V139, P987, DOI 10.3945/jn.108.101451
   Sugiura M, 2015, BRIT J NUTR, V114, P1674, DOI 10.1017/S0007114515003268
   Suzuki K, 2011, CLIN NUTR, V30, P369, DOI 10.1016/j.clnu.2010.12.006
   Vizzuso S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061785
   von Lintig J, 2010, ANNU REV NUTR, V30, P35, DOI 10.1146/annurev-nutr-080508-141027
   World Health Organization (WHO), Obesity and overweight
   Wu L, 2016, EXP BIOL MED, V241, P1879, DOI 10.1177/1535370216657900
   Xiao YD, 2018, FOOD CHEM, V239, P360, DOI 10.1016/j.foodchem.2017.06.107
   Yabuzaki J, 2017, DATABASE-OXFORD, DOI 10.1093/database/bax004
   Yosaee S., 2017, Journal of Nutrition and Food Security, V2, P213
   Yosaee S, 2016, WORLD J DIABETES, V7, P177, DOI 10.4239/wjd.v7.i9.177
   Zhao WE, 2016, RES REP BIOCHEM, V6, P13, DOI 10.2147/RRBC.S83258
NR 68
TC 73
Z9 75
U1 1
U2 31
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD DEC
PY 2020
VL 25
IS 24
AR 5803
DI 10.3390/molecules25245803
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA PL7GV
UT WOS:000603286400001
PM 33316948
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bartlett, PJ
   Gaspers, LD
   Pierobon, N
   Thomas, AP
AF Bartlett, Paula J.
   Gaspers, Lawrence D.
   Pierobon, Nicola
   Thomas, Andrew P.
TI Calcium-dependent regulation of glucose homeostasis in the liver
SO CELL CALCIUM
LA English
DT Article
DE Calcium; Hepatocyte; Mitochondrial metabolism; Glucose homeostasis; IP3
   receptor; Metabolic syndrome; Liver
ID PROTEIN-KINASE-C; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS;
   ENDOPLASMIC-RETICULUM STRESS; CYTOPLASMIC FREE CALCIUM; ISOLATED RAT
   HEPATOCYTES; CA2+ RELEASE CHANNELS; INSULIN-RESISTANCE; GENE-EXPRESSION;
   PERFUSED LIVER; INTACT LIVER
AB A major role of the liver is to integrate multiple signals to maintain normal blood glucose levels. The balance between glucose storage and mobilization is primarily regulated by the counteracting effects of insulin and glucagon. However, numerous signals converge in the liver to ensure energy demand matches the physiological status of the organism. Many circulating hormones regulate glycogenolysis, gluconeogenesis and mitochondrial metabolism by calcium-dependent signaling mechanisms that manifest as cytosolic Ca2+ oscillations. Stimulus-strength is encoded in the Ca2+ oscillation frequency, and also by the range of intercellular Ca2+ wave propagation in the intact liver. In this article, we describe how Ca2+ oscillations and waves can regulate glucose output and oxidative metabolism in the intact liver; how multiple stimuli are decoded though Ca2+ signaling at the organ level, and the implications of Ca2+ signal dysregulation in diseases such as metabolic syndrome and non-alcoholic fatty liver disease. (C) 2014 Published by Elsevier Ltd.
C1 [Bartlett, Paula J.; Gaspers, Lawrence D.; Pierobon, Nicola; Thomas, Andrew P.] Rutgers State Univ, New Jersey Med Sch, Dept Physiol & Pharmacol, Newark, NJ 07102 USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences; Rutgers University Newark
RP Bartlett, PJ (corresponding author), Rutgers State Univ, New Jersey Med Sch, Dept Physiol & Pharmacol, Newark, NJ 07102 USA.
EM paula.bartlett@rutgers.edu
RI Thomas, Andrew/C-6755-2013; Gaspers, Lawrence/W-8766-2019
OI Thomas, Andrew/0000-0002-9026-7467; Gaspers,
   Lawrence/0000-0002-5620-3283
FU NIDDK NIH HHS [R21 DK082954] Funding Source: Medline
CR Amaya MJ, 2013, COMPR PHYSIOL, V3, P515, DOI 10.1002/cphy.c120013
   [Anonymous], DIABETES METABOLISM
   ASHLEY CC, 1968, NATURE, V219, P1168, DOI 10.1038/2191168a0
   Bartlett PJ, 2005, J BIOL CHEM, V280, P21837, DOI 10.1074/jbc.M411843200
   Baughman JM, 2011, NATURE, V476, P341, DOI 10.1038/nature10234
   Bechmann LP, 2012, J HEPATOL, V56, P952, DOI 10.1016/j.jhep.2011.08.025
   Bernard C., 1854, LECONS PHYSICLOGIE E
   Berridge MJ, 2000, NAT REV MOL CELL BIO, V1, P11, DOI 10.1038/35036035
   BERRIDGE MJ, 1988, FASEB J, V2, P3074, DOI 10.1096/fasebj.2.15.2847949
   BERRIE CP, 1995, CELL CALCIUM, V18, P232, DOI 10.1016/0143-4160(95)90068-3
   Betzenhauser MJ, 2009, J BIOL CHEM, V284, P25116, DOI 10.1074/jbc.M109.010132
   Bilzer M, 2006, LIVER INT, V26, P1175, DOI 10.1111/j.1478-3231.2006.01342.x
   Birkenfeld AL., 2013, Hepatology, P1
   BLACKMORE PF, 1986, BIOCHEM J, V237, P235, DOI 10.1042/bj2370235
   BLACKMORE PF, 1979, J BIOL CHEM, V254, P2828
   BLINKS JR, 1982, PROG BIOPHYS MOL BIO, V40, P1, DOI 10.1016/0079-6107(82)90011-6
   Bootman MD, 1996, BIOCHEM J, V314, P347, DOI 10.1042/bj3140347
   Bruce JIE, 2003, CELL CALCIUM, V34, P431, DOI 10.1016/S0143-4160(03)00150-7
   Bruce JIE, 2002, J BIOL CHEM, V277, P1340, DOI 10.1074/jbc.M106609200
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   CASTELEIJN E, 1988, J BIOL CHEM, V263, P6953
   CORNELL RP, 1983, HEPATOLOGY, V3, P188
   Correa PRAV, 2004, BIOCHEM BIOPH RES CO, V322, P718, DOI 10.1016/j.bbrc.2004.07.192
   Craske H, 1999, P NATL ACAD SCI USA, V96, P4426, DOI 10.1073/pnas.96.8.4426
   De Koninck P, 1998, SCIENCE, V279, P227, DOI 10.1126/science.279.5348.227
   De Stefani D, 2011, NATURE, V476, P336, DOI 10.1038/nature10230
   DEHAYE JP, 1981, BIOCHEM J, V194, P949, DOI 10.1042/bj1940949
   Denton RM, 1996, ADV ENZYME REGUL, V36, P183, DOI 10.1016/0065-2571(95)00020-8
   DENTON RM, 1978, BIOCHEM J, V176, P899, DOI 10.1042/bj1760899
   DENTON RM, 1972, BIOCHEM J, V128, P161, DOI 10.1042/bj1280161
   Dixon CJ, 2000, BRIT J PHARMACOL, V129, P764, DOI 10.1038/sj.bjp.0703103
   Dolmetsch RE, 1998, NATURE, V392, P933, DOI 10.1038/31960
   Dupont G, 2000, FASEB J, V14, P279, DOI 10.1096/fasebj.14.2.279
   Dupont G, 2011, COLD SPRING HARBOR P, V3
   EXTON J H, 1987, Diabetes Metabolism Reviews, V3, P163
   EXTON JH, 1967, J BIOL CHEM, V242, P2622
   FERRIS CD, 1991, BIOCHEM BIOPH RES CO, V175, P192, DOI 10.1016/S0006-291X(05)81219-7
   Foskett JK, 2007, PHYSIOL REV, V87, P593, DOI 10.1152/physrev.00035.2006
   Fu SN, 2011, NATURE, V473, P528, DOI 10.1038/nature09968
   GARDEMANN A, 1987, AM J PHYSIOL, V253, pE238, DOI 10.1152/ajpendo.1987.253.3.E238
   Gaspers LD, 2012, CELL CALCIUM, V52, P93, DOI 10.1016/j.ceca.2012.04.009
   Gaspers LD, 2008, METHODS, V46, P224, DOI 10.1016/j.ymeth.2008.09.012
   Gaspers LD, 2005, CELL CALCIUM, V38, P329, DOI 10.1016/j.ceca.2005.06.009
   Gilabert JA, 2000, EMBO J, V19, P6401, DOI 10.1093/emboj/19.23.6401
   Guihard G, 1996, BIOCHEM J, V318, P849, DOI 10.1042/bj3180849
   Hajnóczky G, 1999, J BIOL CHEM, V274, P14157, DOI 10.1074/jbc.274.20.14157
   HAJNOCZKY G, 1995, CELL, V82, P415, DOI 10.1016/0092-8674(95)90430-1
   HAJNOCZKY G, 1993, BIOCHEM J, V293, P413, DOI 10.1042/bj2930413
   HARTMANN H, 1982, EUR J BIOCHEM, V123, P521
   Harzheim D, 2009, P NATL ACAD SCI USA, V106, P11406, DOI 10.1073/pnas.0905485106
   HAUSSINGER D, 1992, TRENDS PHARMACOL SCI, V13, P371, DOI 10.1016/0165-6147(92)90114-L
   HAWORTH RA, 1979, ARCH BIOCHEM BIOPHYS, V195, P460, DOI 10.1016/0003-9861(79)90372-2
   HEMS DA, 1980, PHYSIOL REV, V60, P1
   Hernandez E, 2007, J BIOL CHEM, V282, P10057, DOI 10.1074/jbc.M700746200
   Hu F, 2011, CELL SIGNAL, V23, P1528, DOI 10.1016/j.cellsig.2011.05.008
   Irvine RF, 2003, NAT REV MOL CELL BIO, V4, P586, DOI 10.1038/nrm1152
   Ishibashi H, 2009, SEMIN IMMUNOPATHOL, V31, P399, DOI 10.1007/s00281-009-0155-6
   Jialal I, 2014, J CLIN ENDOCR METAB, V99, P39, DOI 10.1210/jc.2013-3092
   KASAI H, 1993, CELL, V74, P669, DOI 10.1016/0092-8674(93)90514-Q
   KASTING NW, 1985, AM J PHYSIOL, V248, pE420, DOI 10.1152/ajpendo.1985.248.4.E420
   Khan MT, 2006, J BIOL CHEM, V281, P3731, DOI 10.1074/jbc.M509262200
   Kim JA, 2008, CIRC RES, V102, P401, DOI 10.1161/CIRCRESAHA.107.165472
   KNEER NM, 1979, J BIOL CHEM, V254, P2160
   Kopil CM, 2012, J NEUROCHEM, V123, P147, DOI 10.1111/j.1471-4159.2012.07859.x
   KrausFriedmann N, 1996, METABOLISM, V45, P389, DOI 10.1016/S0026-0495(96)90296-6
   Kupzig S, 2005, P NATL ACAD SCI USA, V102, P7577, DOI 10.1073/pnas.0409611102
   Lagoudakis L, 2010, HEPATOLOGY, V52, P602, DOI 10.1002/hep.23673
   Levin BE, 2002, INT REV NEUROBIOL, V51, P219, DOI 10.1016/S0074-7742(02)51007-2
   Li WH, 1998, NATURE, V392, P936, DOI 10.1038/31965
   Liu SB, 2002, INFECT IMMUN, V70, P3433, DOI 10.1128/IAI.70.7.3433-3442.2002
   Maitra U, 2012, J IMMUNOL, V189, P1014, DOI 10.4049/jimmunol.1200857
   MCCORMACK JG, 1990, P NUTR SOC, V49, P57, DOI 10.1079/PNS19900009
   MCCORMACK JG, 1990, PHYSIOL REV, V70, P391, DOI 10.1152/physrev.1990.70.2.391
   MCCORMACK JG, 1979, BIOCHEM J, V180, P533, DOI 10.1042/bj1800533
   Motoyama K, 1999, AM J PHYSIOL-REG I, V276, pR575, DOI 10.1152/ajpregu.1999.276.2.R575
   Nash MS, 2001, NATURE, V413, P381, DOI 10.1038/35096643
   NATHANSON MH, 1995, AM J PHYSIOL-GASTR L, V269, pG167, DOI 10.1152/ajpgi.1995.269.1.G167
   NATHANSON MH, 1994, AM J PHYSIOL, V267, pG338, DOI 10.1152/ajpgi.1994.267.3.G338
   Newton AC, 2001, CHEM REV, V101, P2353, DOI 10.1021/cr0002801
   Niessen H, 2000, FEBS LETT, V466, P112, DOI 10.1016/S0014-5793(99)01770-6
   NIIJIMA A, 1973, JPN J PHYSIOL, V23, P497
   Oancea E, 1998, CELL, V95, P307, DOI 10.1016/S0092-8674(00)81763-8
   Ozcan L, 2013, CELL METAB, V18, P803, DOI 10.1016/j.cmet.2013.10.011
   Pan X, 2013, NAT CELL BIOL, V15, P1464, DOI 10.1038/ncb2868
   Park SW, 2010, P NATL ACAD SCI USA, V107, P19320, DOI 10.1073/pnas.1012044107
   Patel S, 1999, NAT CELL BIOL, V1, P467, DOI 10.1038/70249
   Pierobon N, 2006, J BIOL CHEM, V281, P34086, DOI 10.1074/jbc.M607788200
   Politi A, 2006, BIOPHYS J, V90, P3120, DOI 10.1529/biophysj.105.072249
   Putney JW, 2008, J PHYSIOL-LONDON, V586, P3055, DOI 10.1113/jphysiol.2008.153221
   Qureshi K, 2007, WORLD J GASTROENTERO, V13, P3540, DOI 10.3748/wjg.v13.i26.3540
   RIZZUTO R, 1994, J CELL BIOL, V126, P1183, DOI 10.1083/jcb.126.5.1183
   RIZZUTO R, 1993, SCIENCE, V262, P744, DOI 10.1126/science.8235595
   RIZZUTO R, 1992, NATURE, V358, P325, DOI 10.1038/358325a0
   Rizzuto R, 2012, NAT REV MOL CELL BIO, V13, P566, DOI 10.1038/nrm3412
   Robb-Gaspers LD, 1998, BBA-BIOENERGETICS, V1366, P17, DOI 10.1016/S0005-2728(98)00118-2
   Robb-Gaspers LD, 1998, EMBO J, V17, P4987, DOI 10.1093/emboj/17.17.4987
   ROBBGASPERS LD, 1995, J BIOL CHEM, V270, P8102, DOI 10.1074/jbc.270.14.8102
   ROONEY TA, 1990, J BIOL CHEM, V265, P10792
   ROONEY TA, 1989, J BIOL CHEM, V264, P17131
   Rooney TA, 1996, J BIOL CHEM, V271, P19817, DOI 10.1074/jbc.271.33.19817
   ROONEY TA, 1991, PHARMACOL THERAPEUT, V49, P223, DOI 10.1016/0163-7258(91)90056-R
   Salazar C, 2008, BIOPHYS J, V94, P1203, DOI 10.1529/biophysj.107.113084
   Saltiel AR, 2001, NATURE, V414, P799, DOI 10.1038/414799a
   Samuel VT, 2012, CELL, V148, P852, DOI 10.1016/j.cell.2012.02.017
   SANCHEZBUENO A, 1994, BIOCHEM BIOPH RES CO, V198, P728, DOI 10.1006/bbrc.1994.1105
   SANCHEZBUENO A, 1990, BIOCHEM J, V268, P627, DOI 10.1042/bj2680627
   SANCHEZBUENO A, 1993, BIOCHEM J, V291, P169, DOI 10.1042/bj2910169
   Schlosser SF, 1996, P NATL ACAD SCI USA, V93, P9948, DOI 10.1073/pnas.93.18.9948
   Schreuder TCMA, 2008, WORLD J GASTROENTERO, V14, P2474, DOI 10.3748/wjg.14.2474
   Screaton RA, 2004, CELL, V119, P61, DOI 10.1016/j.cell.2004.09.015
   SHIMAZU T, 1966, NATURE, V210, P1178, DOI 10.1038/2101178a0
   SHIMAZU T, 1965, SCIENCE, V150, P1607, DOI 10.1126/science.150.3703.1607
   SHIMAZU T, 1987, Diabetes Metabolism Reviews, V3, P185
   Silva A.C.M.D., 1998, GEN PHARMACOL-VASC S, V30, P655
   Sneyd J, 2006, P NATL ACAD SCI USA, V103, P1675, DOI 10.1073/pnas.0506135103
   SOMOGYI R, 1992, BIOCHEM J, V286, P869, DOI 10.1042/bj2860869
   Tanimura A, 2009, J BIOL CHEM, V284, P8901, DOI 10.1074/jbc.M805865200
   Thomas A.P., 1995, CIBA F SYMP, V188, P35
   Thomas AP, 1996, FASEB J, V10, P1505, DOI 10.1096/fasebj.10.13.8940296
   THOMAS AP, 1991, CELL CALCIUM, V12, P111, DOI 10.1016/0143-4160(91)90013-5
   THOMAS AP, 1995, BIOCHEM SOC T, V23, P642, DOI 10.1042/bst0230642
   THOMAS AP, 1995, CIBA F SYMP, V188, P18
   THOMAS AP, 1985, J BIOL CHEM, V260, P5963
   Thomas D, 2000, CURR BIOL, V10, P8, DOI 10.1016/S0960-9822(99)00258-4
   Thurley K, 2011, BIOPHYS J, V101, P2638, DOI 10.1016/j.bpj.2011.10.030
   Thuy S, 2008, J NUTR, V138, P1452, DOI 10.1093/jn/138.8.1452
   Tomida T, 2003, EMBO J, V22, P3825, DOI 10.1093/emboj/cdg381
   Tordjmann T, 1997, EMBO J, V16, P5398, DOI 10.1093/emboj/16.17.5398
   Violin JD, 2003, J CELL BIOL, V161, P899, DOI 10.1083/jcb.200302125
   Walker SA, 2004, EMBO J, V23, P1749, DOI 10.1038/sj.emboj.7600197
   Wang YG, 2012, NATURE, V485, P128, DOI 10.1038/nature10988
   WATANABE J, 1988, J HISTOCHEM CYTOCHEM, V36, P1081, DOI 10.1177/36.9.2841370
   WHIPPS DE, 1987, BIOCHEM J, V241, P835, DOI 10.1042/bj2410835
   WOODS NM, 1986, NATURE, V319, P600, DOI 10.1038/319600a0
   WOODS NM, 1987, CELL CALCIUM, V8, P79, DOI 10.1016/0143-4160(87)90038-8
   Yamamoto-Hino M, 1998, J CELL BIOL, V141, P135, DOI 10.1083/jcb.141.1.135
NR 136
TC 69
Z9 75
U1 1
U2 43
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0143-4160
EI 1532-1991
J9 CELL CALCIUM
JI Cell Calcium
PD JUN
PY 2014
VL 55
IS 6
SI SI
BP 306
EP 316
DI 10.1016/j.ceca.2014.02.007
PG 11
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA AK7PA
UT WOS:000338619000005
PM 24630174
DA 2025-06-11
ER

PT J
AU Guimaraes, VHD
   Lelis, DD
   Oliveira, LP
   Borém, LMA
   Guimaraes, FAD
   Farias, LC
   de Paula, AMB
   Guimaraes, ALS
   Santos, SHS
AF Guimaraes, Victor Hugo Dantas
   Lelis, Deborah de Farias
   Oliveira, Luis Paulo
   Borem, Luciana Mendes Araujo
   Guimaraes, Felipe Alberto Dantas
   Farias, Lucyana Conceicao
   de Paula, Alfredo Mauricio Batista
   Guimaraes, Andre Luiz Sena
   Santos, Sergio Henrique Sousa
TI Comparative study of dietary fat: lard and sugar as a better obesity and
   metabolic syndrome mice model
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Animal model; dyslipidemia; oxidative stress; hyperglycaemia; fat liver
ID INSULIN-RESISTANCE; ADIPOSE-TISSUE; ANIMAL-MODELS; HEPATIC STEATOSIS;
   HIGH-CARBOHYDRATE; GENE-EXPRESSION; CAFETERIA DIET; LIVER; ACCUMULATION;
   INFLAMMATION
AB Background
   Diet macronutrient heterogeneity hinders animal studies' data extrapolation from metabolic disorders to human diseases.
   Objective
   The present study aimed to evaluate different fat-diet compositions' effect on inducing lipid/glucose metabolism alterations in mice.
   Methods
   Swiss male mice were fed for 12 weeks with five different diets: Standard Diet (ST), American Institute of Nutrition 93 for growth (AIN93G) high-butter/high-sugar (HBHS), high-lard/high-sugar (HLHS), and high-oil/high-sugar diet (soybean oil) (HOHS). Several parameters, such as serum biochemistry, histology, and liver mRNA expression, were accessed.
   Results
   The main findings revealed that the HLHS diet dramatically altered liver metabolism inducing hepatic steatosis and increased total cholesterol, triglycerides, VLDL, increasing liver CCAAT/enhancer binding protein (CEBP-alpha), Acetyl-CoA carboxylase (ACC) and Catalase (CAT) mRNA expression. Moreover, the HLHS diet increased glucose intolerance and reduced insulin sensitivity.
   Conclusions
   High-fat/high-sugar diets are efficient to induce obesity and metabolic syndrome-associated alterations, and diets enriched with lard and sugar showed more effective results.
C1 [Guimaraes, Victor Hugo Dantas; Lelis, Deborah de Farias; Oliveira, Luis Paulo; Guimaraes, Felipe Alberto Dantas; Farias, Lucyana Conceicao; de Paula, Alfredo Mauricio Batista; Guimaraes, Andre Luiz Sena; Santos, Sergio Henrique Sousa] Univ Estadual Montes Claros Unimontes, Postgrad Program Hlth Sci, Lab Hlth Sci, Montes Claros, MG, Brazil.
   [Borem, Luciana Mendes Araujo] Fac Integradas Pitagoras, Dept Med, Montes Claros, MG, Brazil.
   [Santos, Sergio Henrique Sousa] Univ Fed Minas Gerais UFMG, Postgrad Program Food & Hlth, Inst Agr Sci ICA, Montes Claros, MG, Brazil.
C3 Universidade Estadual de Montes Claros
RP Santos, SHS (corresponding author), Univ Fed Minas Gerais UFMG, Food Engn Coll, Inst Agr Sci, Ave Univ 1000 Univ, BR-39404547 Montes Claros, MG, Brazil.
EM sergiosousas@hotmail.com
RI De Paula, Alfredo/K-3015-2012; Santos, Sergio/GPS-8751-2022; Guimarães,
   Victor/AGJ-6023-2022; Guimaraes, Andre/D-8122-2011
OI Santos, Sergio/0000-0002-7788-5447; De Paula,
   Alfredo/0000-0002-8715-0030; Guimaraes, Victor/0000-0002-4424-8142;
   Guimaraes, Andre/0000-0002-3162-3206
FU Coordenadoria de Aperfeicoamento do Pessoal de Nivel Superior (CAPES);
   Conselho Nacional de Desenvolvimento Cientifico (CNPQ); Fundacao de
   Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
FX This work was supported by the Coordenadoria de Aperfeicoamento do
   Pessoal de Nivel Superior (CAPES) and Conselho Nacional de
   Desenvolvimento Cientifico (CNPQ) and Fundacao de Amparo a Pesquisa do
   Estado de Minas Gerais (FAPEMIG).
CR Andrade JG, 2014, CAN J CARDIOL, V30, pS431
   Andrikopoulos S., 2008, AM J PHYSL ENDOCRINO, V295, pE1323
   [Anonymous], 2016, LANCET, V387, P200, DOI 10.1016/S0140-6736(16)00093-3
   Ardisson LP, 2012, INT J CARDIOL, V156, P265, DOI 10.1016/j.ijcard.2010.10.128
   Bhathena SJ, 2002, AM J CLIN NUTR, V76, P1191, DOI 10.1093/ajcn/76.6.1191
   Bourlier V, 2009, DIABETES METAB, V35, P251, DOI 10.1016/j.diabet.2009.05.001
   Browning JD, 2004, J CLIN INVEST, V114, P147, DOI 10.1172/JCI200422422
   Caimari A, 2010, OMICS, V14, P129, DOI 10.1089/omi.2009.0092
   Dalboge LS, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0135634
   Della Vedova MC, 2016, NUTR METAB INSIGHTS, V9, P93, DOI 10.4137/NMI.S32907
   DiNicolantonio JJ, 2018, OPEN HEART, V5, DOI 10.1136/openhrt-2018-000946
   DiNicolantonio JJ, 2016, PROG CARDIOVASC DIS, V58, P464, DOI 10.1016/j.pcad.2015.11.006
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Erlanson-Albertsson C, 2005, BASIC CLIN PHARMACOL, V97, P61, DOI 10.1111/j.1742-7843.2005.pto_179.x
   Farrell GC, 2006, HEPATOLOGY S1, V43, pS99
   FAUST IM, 1978, AM J PHYSIOL, V235, pE279, DOI 10.1152/ajpendo.1978.235.3.E279
   Fernandes MR, 2016, ACTA CIR BRAS, V31, P840, DOI [10.1590/S0102-865020160120000010, 10.1590/s0102-865020160120000010]
   Fernández-Domínguez I, 2011, ULTRASOUND MED BIOL, V37, P1161, DOI 10.1016/j.ultrasmedbio.2011.04.012
   de Almeida MEF, 2009, REV NUTR, V22, P51, DOI 10.1590/S1415-52732009000100005
   Flanagan AM, 2008, J NUTR BIOCHEM, V19, P505, DOI 10.1016/j.jnutbio.2007.06.005
   Gross LS, 2004, AM J CLIN NUTR, V79, P774
   Hariri N, 2010, NUTR RES REV, V23, P270, DOI 10.1017/S0954422410000168
   Heyne A, 2009, ADDICT BIOL, V14, P373, DOI 10.1111/j.1369-1600.2009.00175.x
   Isken F, 2010, J NUTR BIOCHEM, V21, P278, DOI 10.1016/j.jnutbio.2008.12.012
   Islam MS, 2009, METHOD FIND EXP CLIN, V31, P249, DOI 10.1358/mf.2009.31.4.1362513
   Jaki T, 2009, STAT BIOPHARM RES, V1, P176, DOI 10.1198/sbr.2009.0025
   Jameel F, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-195
   Jin JL, 2013, CELL REP, V3, P831, DOI 10.1016/j.celrep.2013.02.009
   Kakimoto PA, 2016, REDOX BIOL, V8, P216, DOI 10.1016/j.redox.2016.01.009
   Koplay M, 2015, WORLD J HEPATOL, V7, P769, DOI 10.4254/wjh.v7.i5.769
   Krauss RM, 2001, J NUTR, V131, p340S
   Kuroda H, 2012, WORLD J GASTROENTERO, V18, P3889, DOI 10.3748/wjg.v18.i29.3889
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   Lupsor-Platon M, 2014, MED ULTRASON, V16, P236
   Maioli TU, 2016, INFLAMM RES, V65, P169, DOI 10.1007/s00011-015-0902-1
   Ferreira AVM, 2014, NUTRITION, V30, P1138, DOI 10.1016/j.nut.2014.02.017
   Ferreira AVM, 2011, INFLAMMATION, V34, P139, DOI 10.1007/s10753-010-9217-0
   Matsusue K, 2004, MOL ENDOCRINOL, V18, P2751, DOI 10.1210/me.2004-0213
   Mendes LG, 2018, LIFE SCI, V209, P341, DOI 10.1016/j.lfs.2018.08.034
   Méndez-Sánchez N, 2007, LIVER INT, V27, P423, DOI 10.1111/j.1478-3231.2007.01483.x
   Moghadasian MH, 2001, LAB INVEST, V81, P1173, DOI 10.1038/labinvest.3780331
   Ng M., 2014, Lancet, V384
   O'Rahilly S, 2008, DIABETES, V57, P2905, DOI 10.2337/db08-0210
   Ogden CL, 2007, GASTROENTEROLOGY, V132, P2087, DOI 10.1053/j.gastro.2007.03.052
   Oliveira MC, 2013, OBESITY SILVER SPRIN, V21, pE396
   Panchal SK, 2011, J BIOMED BIOTECHNOL, DOI 10.1155/2011/351982
   REAVEN GM, 1991, DIABETES CARE, V14, P33, DOI 10.2337/diacare.14.4.33
   REEVES PG, 1993, J NUTR, V123, P1939, DOI 10.1093/jn/123.11.1939
   RICE MC, 1980, NATURE, V283, P157, DOI 10.1038/283157a0
   Russell JC, 2006, CARDIOVASC PATHOL, V15, P318, DOI 10.1016/j.carpath.2006.09.001
   Sampey BP, 2011, OBESITY, V19, P1109, DOI 10.1038/oby.2011.18
   SAMUELS LT, 1948, J NUTR, V36, P205
   Sanchez-Bayle M, 2008, EUR J PEDIATR, V167, P149, DOI 10.1007/s00431-007-0439-6
   Santos JF, 2015, NUTR HOSP, V31, P2140, DOI 10.3305/nh.2015.31.5.8597
   Santos SHS, 2012, REGUL PEPTIDES, V178, P64, DOI 10.1016/j.regpep.2012.06.009
   Sanyal AJ, 2001, GASTROENTEROLOGY, V120, P1183, DOI 10.1053/gast.2001.23256
   Saper CB, 2002, NEURON, V36, P199, DOI 10.1016/S0896-6273(02)00969-8
   Speakman J, 2007, OBES REV, V8, P55, DOI 10.1111/j.1467-789X.2007.00319.x
   Speakman JR, 2019, INT J OBESITY, V43, P1491, DOI 10.1038/s41366-019-0363-7
   Stanhope KL, 2009, J CLIN INVEST, V119, P1322, DOI 10.1172/JCI37385
   Sun K, 2011, J CLIN INVEST, V121, P2094, DOI 10.1172/JCI45887
   Veeramani C, 2017, BIOMED PHARMACOTHER, V96, P1349, DOI 10.1016/j.biopha.2017.11.072
   Wakil S. J., 2009, J LIPID RES S, V50, pS138
   West DB, 1992, AM J PHYSL 2, V262, pR1025
   Wong SH, 2016, J PHYS ACT HLTH S2, V13, pS169
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yang ZH, 2012, DIABETOL METAB SYNDR, V4, DOI 10.1186/1758-5996-4-32
   Yin YN, 2010, WORLD J GASTROENTERO, V16, P3394, DOI 10.3748/wjg.v16.i27.3394
   Zeeni N, 2015, INFLAMM RES, V64, P501, DOI 10.1007/s00011-015-0831-z
   Zhang ZH, 2015, EXP ANIM TOKYO, V64, P435, DOI 10.1538/expanim.14-0086
NR 70
TC 19
Z9 19
U1 1
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD MAR 4
PY 2023
VL 129
IS 2
BP 449
EP 459
DI 10.1080/13813455.2020.1835986
EA NOV 2020
PG 11
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA A3VJ1
UT WOS:000588511400001
PM 33176505
DA 2025-06-11
ER

PT J
AU Ponziani, FR
   Pecere, S
   Gasbarrini, A
   Ojetti, V
AF Ponziani, Francesca Romana
   Pecere, Silvia
   Gasbarrini, Antonio
   Ojetti, Veronica
TI Physiology and pathophysiology of liver lipid metabolism
SO EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
LA English
DT Review
DE cardiovascular disease; cholesterol; gut microbiota; liver lipid
   metabolism; metabolic syndrome; NAFLD; NASH
ID TUMOR-NECROSIS-FACTOR; DE-NOVO LIPOGENESIS; ENDOPLASMIC-RETICULUM
   STRESS; NF-KAPPA-B; UNFOLDED PROTEIN RESPONSE; FATTY LIVER;
   INSULIN-RESISTANCE; GENE-EXPRESSION; GUT MICROBIOTA; HEPATIC STEATOSIS
AB Liver lipid metabolism and its modulation are involved in many pathologic conditions, such as obesity, non-alcoholic fatty liver disease, diabetes mellitus, atherosclerosis and cardiovascular disease. Metabolic disorders seem to share a similar background of low-grade chronic inflammation, even if the pathophysiological mechanisms leading to tissue and organ damage have not been completely clarified yet. The accumulation of neutral lipids in the liver is now recognized as a beneficial and protective mechanism; on the other hand, lipoperoxidation is involved in the development and progression of non-alcoholic steatohepatitis. The role of the gut microbiota in liver lipid metabolism has been the object of recent scientific investigations. It is likely that the gut microbiota is involved in a complex metabolic modulation and the translocation of gut microflora may also contribute to maintaining the low-grade inflammatory status of metabolic syndrome. Therefore, lipid metabolism pathology has vague limits and complex mechanisms, and the knowledge of these is essential to guide diagnostic and therapeutic decisions.
C1 [Ponziani, Francesca Romana; Pecere, Silvia; Gasbarrini, Antonio; Ojetti, Veronica] Agostino Gemelli Hosp, Internal Med & Gastroenterol, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Pecere, S (corresponding author), Agostino Gemelli Hosp, Internal Med & Gastroenterol, Rome, Italy.
EM silvia.pecere@gmail.com
RI Ojetti, V./AFS-4851-2022; Gasbarrini, Antonio/AAB-8487-2019; pecere,
   silvia/M-2541-2018; Ponziani, Francesca Romana/E-4136-2016
OI pecere, silvia/0000-0002-4401-7344; Ponziani, Francesca
   Romana/0000-0002-5924-6238; Gasbarrini, Antonio/0000-0003-4863-6924;
   Gasbarrini, Antonio/0000-0002-6230-1779
CR Abreu MT, 2010, NAT REV IMMUNOL, V10, P131, DOI 10.1038/nri2707
   Abu Shanab A, 2011, DIGEST DIS SCI, V56, P1524, DOI 10.1007/s10620-010-1447-3
   Adams LA, 2005, GASTROENTEROLOGY, V129, P113, DOI 10.1053/j.gastro.2005.04.014
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Amar J, 2011, EMBO MOL MED, V3, P559, DOI 10.1002/emmm.201100159
   Anstee QM, 2013, NAT REV GASTRO HEPAT, V10, P330, DOI 10.1038/nrgastro.2013.41
   Aon MA, 2014, FRONT PHYSIOL, V5, DOI 10.3389/fphys.2014.00282
   Argo CK, 2009, J HEPATOL, V51, P371, DOI 10.1016/j.jhep.2009.03.019
   Auguet T, 2013, CLIN BIOCHEM, V46, P202, DOI 10.1016/j.clinbiochem.2012.11.006
   Bäckhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Bechmann LP, 2010, LIVER INT, V30, P850, DOI 10.1111/j.1478-3231.2010.02248.x
   Berk PD, 2008, HEPATOLOGY, V48, P1362, DOI 10.1002/hep.22632
   Berk Paul D, 2005, Trans Am Clin Climatol Assoc, V116, P335
   Berlanga A, 2014, CLIN EXP GASTROENTER, V7, P221, DOI 10.2147/CEG.S62831
   Bieghs V, 2010, GASTROENTEROLOGY, V138, P2477, DOI 10.1053/j.gastro.2010.02.051
   Brown EM, 2013, NAT IMMUNOL, V14, P660, DOI 10.1038/ni.2611
   Brunt EM, 2011, HEPATOLOGY, V53, P810, DOI 10.1002/hep.24127
   Caldwell SH, 2009, HEPATOLOGY, V49, P1888, DOI 10.1002/hep.22851
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Chalasani N, 2012, HEPATOLOGY, V55, P2005, DOI 10.1002/hep.25762
   Choi JH, 2013, ARCH MED RES, V44, P115, DOI 10.1016/j.arcmed.2013.01.007
   Choi SE, 2011, ENDOCRINOLOGY, V152, P816, DOI 10.1210/en.2010-0924
   Cohen DE, 2013, SEMIN LIVER DIS, V33, P380, DOI 10.1055/s-0033-1358519
   Crespo J, 2001, HEPATOLOGY, V34, P1158, DOI 10.1053/jhep.2001.29628
   Daniels TF, 2009, INT J BIOL SCI, V5, P474
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   Deng J, 2004, MOL CELL BIOL, V24, P10161, DOI 10.1128/MCB.24.23.10161-10168.2004
   Dijkstra Albert J, 2008, TRANSFATTY ACIDS
   Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI23621
   Dubuquoy C, 2013, CLIN RES HEPATOL GAS, V37, P30, DOI 10.1016/j.clinre.2012.06.014
   Dumas ME, 2006, P NATL ACAD SCI USA, V103, P12511, DOI 10.1073/pnas.0601056103
   Ekstedt M, 2006, HEPATOLOGY, V44, P865, DOI 10.1002/hep.21327
   El Kasmi KC, 2012, HEPATOLOGY, V55, P1518, DOI 10.1002/hep.25500
   Endo M, 2007, EXP BIOL MED, V232, P614
   FIELDING CJ, 1972, BIOCHEM BIOPH RES CO, V46, P1493, DOI 10.1016/0006-291X(72)90776-0
   Finn PF, 2006, NUTRITION, V22, P830, DOI 10.1016/j.nut.2006.04.008
   Furet JP, 2010, DIABETES, V59, P3049, DOI 10.2337/db10-0253
   Gary-Bobo M, 2007, HEPATOLOGY, V46, P122, DOI 10.1002/hep.21641
   Ge FX, 2010, AM J PHYSIOL-GASTR L, V299, pG855, DOI 10.1152/ajpgi.00434.2009
   GINSBERG HN, 1994, MED CLIN N AM, V78, P1
   Goldberg IJ, 1996, J LIPID RES, V37, P693
   GOLDSTEIN JL, 1990, NATURE, V343, P425, DOI 10.1038/343425a0
   Gregor MF, 2009, DIABETES, V58, P693, DOI 10.2337/db08-1220
   Han MS, 2008, J LIPID RES, V49, P84, DOI 10.1194/jlr.M700184-JLR200
   Hardy S, 2003, J BIOL CHEM, V278, P31861, DOI 10.1074/jbc.M300190200
   Haukeland JW, 2006, J HEPATOL, V44, P1167, DOI 10.1016/j.jhep.2006.02.011
   Hebbachi AM, 2001, J LIPID RES, V42, P1609
   Henao-Mejia J, 2012, NATURE, V482, P179, DOI 10.1038/nature10809
   Herman MA, 2012, NATURE, V484, P333, DOI 10.1038/nature10986
   HERZ J, 1995, P NATL ACAD SCI USA, V92, P4611, DOI 10.1073/pnas.92.10.4611
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Hui DY, 2005, SEMIN CELL DEV BIOL, V16, P183, DOI 10.1016/j.semcdb.2005.01.003
   Hui JM, 2004, HEPATOLOGY, V40, P46, DOI 10.1002/hep.20280
   Ilan Y, 2012, WORLD J GASTROENTERO, V18, P2609, DOI 10.3748/wjg.v18.i21.2609
   JAUHIAINEN M, 1993, J BIOL CHEM, V268, P4032
   JONES PJH, 1990, J LIPID RES, V31, P667
   Jourdan T, 2012, HEPATOLOGY, V55, P790, DOI 10.1002/hep.24733
   JUMP DB, 1994, J LIPID RES, V35, P1076
   Kaser S, 2005, GUT, V54, P117, DOI 10.1136/gut.2003.037010
   Kaufman RJ, 2002, J CLIN INVEST, V110, P1389, DOI 10.1172/JC1200216886
   KERN PA, 1995, J CLIN INVEST, V95, P2111, DOI 10.1172/JCI117899
   Kersten S, 2001, EMBO REP, V2, P282, DOI 10.1093/embo-reports/kve071
   Knight BL, 2005, BIOCHEM J, V389, P413, DOI 10.1042/BJ20041896
   Kobayashi K, 1996, J BIOL CHEM, V271, P6852, DOI 10.1074/jbc.271.12.6852
   Kohjima M, 2007, INT J MOL MED, V20, P351
   Kotronen A, 2007, J CLIN ENDOCR METAB, V92, P3490, DOI 10.1210/jc.2007-0482
   Kumari M, 2012, CELL METAB, V15, P691, DOI 10.1016/j.cmet.2012.04.008
   Lambertucci RH, 2008, J CELL PHYSIOL, V216, P796, DOI 10.1002/jcp.21463
   Larter CZ, 2010, J GASTROEN HEPATOL, V25, P672, DOI 10.1111/j.1440-1746.2010.06253.x
   Lesmana CRA, 2009, J DIGEST DIS, V10, P201, DOI 10.1111/j.1751-2980.2009.00386.x
   Lewis GF, 2004, DIABETES, V53, P2893, DOI 10.2337/diabetes.53.11.2893
   Li JZ, 2012, J CLIN INVEST, V122, P4130, DOI 10.1172/JCI65179
   Lloyd-Jones D, 2009, CIRCULATION, V119, pE21, DOI 10.1161/CIRCULATIONAHA.108.191261
   Lodhi IJ, 2011, TRENDS ENDOCRIN MET, V22, P1, DOI 10.1016/j.tem.2010.09.002
   Lucero D, 2011, CLIN CHIM ACTA, V412, P587, DOI 10.1016/j.cca.2010.12.012
   Malhi H, 2008, SEMIN LIVER DIS, V28, P360, DOI 10.1055/s-0028-1091980
   Mallat A, 2011, BRIT J PHARMACOL, V163, P1432, DOI 10.1111/j.1476-5381.2011.01397.x
   Martin FPJ, 2008, MOL SYST BIOL, V4, DOI 10.1038/msb4100190
   Martin G, 2000, GENOMICS, V66, P296, DOI 10.1006/geno.2000.6191
   Merkel M, 2002, J LIPID RES, V43, P1997, DOI 10.1194/jlr.R200015-JLR200
   Miele L, 2009, HEPATOLOGY, V49, P1877, DOI 10.1002/hep.22848
   Miksztowicz V, 2012, DIABETES-METAB RES, V28, P535, DOI 10.1002/dmrr.2312
   Million M, 2013, CLIN MICROBIOL INFEC, V19, P305, DOI 10.1111/1469-0691.12172
   Mouzaki M, 2013, HEPATOLOGY, V58, P120, DOI 10.1002/hep.26319
   NEESE RA, 1993, AM J PHYSIOL, V264, pE136, DOI 10.1152/ajpendo.1993.264.1.E136
   Neish AS, 2009, GASTROENTEROLOGY, V136, P65, DOI 10.1053/j.gastro.2008.10.080
   Neuschwander-Tetri BA, 2010, HEPATOLOGY, V52, P774, DOI 10.1002/hep.23719
   Nguyen P, 2008, J ANIM PHYSIOL AN N, V92, P272, DOI 10.1111/j.1439-0396.2007.00752.x
   Noguchi Y, 2009, J BIOL CHEM, V284, P33425, DOI 10.1074/jbc.M109.049478
   Novak TE, 2003, AM J PHYSIOL-LUNG C, V284, pL84, DOI 10.1152/ajplung.00077.2002
   Osei-Hyiaman D, 2008, J CLIN INVEST, V118, P3160, DOI 10.1172/JCI34827
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Pais R, 2013, J HEPATOL, V59, P550, DOI 10.1016/j.jhep.2013.04.027
   Park SK, 2013, HEPATOLOGY, V57, P1378, DOI 10.1002/hep.26183
   PATTNAIK NM, 1978, BIOCHIM BIOPHYS ACTA, V530, P428, DOI 10.1016/0005-2760(78)90163-7
   Patton HM, 2010, AM J GASTROENTEROL, V105, P2093, DOI 10.1038/ajg.2010.152
   Peretti N, 2011, ADV CLIN CHEM, V54, P81
   Pérez-Carreras M, 2003, HEPATOLOGY, V38, P999, DOI 10.1053/jhep.2003.50398
   Perry RJ, 2014, NATURE, V510, P84, DOI 10.1038/nature13478
   Petersen KF, 2007, P NATL ACAD SCI USA, V104, P12587, DOI 10.1073/pnas.0705408104
   Postic C, 2008, J CLIN INVEST, V118, P829, DOI 10.1172/JCI34275
   Puri P, 2008, GASTROENTEROLOGY, V134, P568, DOI 10.1053/j.gastro.2007.10.039
   REDGRAVE TG, 1987, BIOCHIM BIOPHYS ACTA, V921, P154, DOI 10.1016/0005-2760(87)90182-2
   Ricchi M, 2009, J GASTROEN HEPATOL, V24, P830, DOI 10.1111/j.1440-1746.2008.05733.x
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Rigotti A, 1997, CURR OPIN LIPIDOL, V8, P181, DOI 10.1097/00041433-199706000-00009
   Robertson Graham, 2001, American Journal of Physiology, V281, pG1135
   Ron D, 2007, NAT REV MOL CELL BIO, V8, P519, DOI 10.1038/nrm2199
   Schadinger SE, 2005, AM J PHYSIOL-ENDOC M, V288, pE1195, DOI 10.1152/ajpendo.00513.2004
   Schmid AI, 2011, DIABETES CARE, V34, P448, DOI 10.2337/dc10-1076
   Schwarz JM, 2003, AM J CLIN NUTR, V77, P43, DOI 10.1093/ajcn/77.1.43
   Scorrano L, 2003, SCIENCE, V300, P135, DOI 10.1126/science.1081208
   Senn JJ, 2006, J BIOL CHEM, V281, P26865, DOI 10.1074/jbc.M513304200
   Sharma NK, 2008, J CLIN ENDOCR METAB, V93, P4532, DOI 10.1210/jc.2008-1001
   Shen LL, 2011, MOL BIOL REP, V38, P553, DOI 10.1007/s11033-010-0140-0
   Simmons RK, 2010, DIABETOLOGIA, V53, P600, DOI 10.1007/s00125-009-1620-4
   Söderberg C, 2010, HEPATOLOGY, V51, P595, DOI 10.1002/hep.23314
   Sookoian S, 2011, HEPATOLOGY, V53, P1883, DOI 10.1002/hep.24283
   SPECTOR AA, 1985, J LIPID RES, V26, P1015
   Spencer MD, 2011, GASTROENTEROLOGY, V140, P976, DOI 10.1053/j.gastro.2010.11.049
   Strable MS, 2010, CRIT REV BIOCHEM MOL, V45, P199, DOI 10.3109/10409231003667500
   Sunny NE, 2011, CELL METAB, V14, P804, DOI 10.1016/j.cmet.2011.11.004
   Tailleux A, 2012, BBA-MOL CELL BIOL L, V1821, P809, DOI 10.1016/j.bbalip.2011.10.016
   Tam J, 2010, J CLIN INVEST, V120, P2953, DOI 10.1172/JCI42551
   Tilg H, 2010, HEPATOLOGY, V52, P1836, DOI 10.1002/hep.24001
   Timlin MT, 2005, AM J CLIN NUTR, V81, P35
   Trigatti BL, 1999, BIOCHEM BIOPH RES CO, V255, P34, DOI 10.1006/bbrc.1998.0123
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Tzotzas T, 2009, OBES REV, V10, P403, DOI 10.1111/j.1467-789X.2009.00586.x
   Vance DE, 2008, CURR OPIN LIPIDOL, V19, P229, DOI 10.1097/MOL.0b013e3282fee935
   Vanden Berghe W, 2003, ADV EXP MED BIOL, V544, P181
   Velagapudi VR, 2010, J LIPID RES, V51, P1101, DOI 10.1194/jlr.M002774
   Wang N, 2000, J BIOL CHEM, V275, P33053, DOI 10.1074/jbc.M005438200
   Wang ZN, 2011, NATURE, V472, P57, DOI 10.1038/nature09922
   Wei YZ, 2008, WORLD J GASTROENTERO, V14, P193, DOI 10.3748/wjg.14.193
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Weltman MD, 1998, HEPATOLOGY, V27, P128, DOI 10.1002/hep.510270121
   Westerbacka J, 2007, DIABETES, V56, P2759, DOI 10.2337/db07-0156
   Wieckowska A, 2008, AM J GASTROENTEROL, V103, P1372, DOI 10.1111/j.1572-0241.2007.01774.x
   Wigg AJ, 2001, GUT, V48, P206, DOI 10.1136/gut.48.2.206
   Wilfling F, 2014, CURR OPIN CELL BIOL, V29, P39, DOI 10.1016/j.ceb.2014.03.008
   Xiao CT, 2008, CIRC RES, V103, P159, DOI 10.1161/CIRCRESAHA.108.178756
   Xie CL, 2000, J LIPID RES, V41, P1278
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Xu X, 2013, SEMIN LIVER DIS, V33, P301, DOI 10.1055/s-0033-1358523
   Yamaguchi K, 2007, HEPATOLOGY, V45, P1366, DOI 10.1002/hep.21655
   Yamazaki H, 2009, J IMMUNOL, V183, P1480, DOI 10.4049/jimmunol.0900017
   Yki-Jarvinen H., 2011, Oxford Textbook of Endocrinology and Diabetes
   Zhang KZ, 2006, NEUROLOGY, V66, pS102, DOI 10.1212/01.wnl.0000192306.98198.ec
   ZHANG SH, 1992, SCIENCE, V258, P468, DOI 10.1126/science.1411543
   ZHOU SL, 1992, J BIOL CHEM, V267, P14456
   ZHOU SL, 1995, P SOC EXP BIOL MED, V208, P263
   Zhu LX, 2013, HEPATOLOGY, V57, P601, DOI 10.1002/hep.26093
NR 155
TC 94
Z9 117
U1 1
U2 78
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1747-4124
EI 1747-4132
J9 EXPERT REV GASTROENT
JI Expert Rev. Gastroenterol. Hepatol.
PD AUG
PY 2015
VL 9
IS 8
BP 1055
EP 1067
DI 10.1586/17474124.2015.1056156
PG 13
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA CN2NT
UT WOS:000358259300005
PM 26070860
DA 2025-06-11
ER

PT J
AU De Vogli, R
   Chandola, T
   Marmot, MG
AF De Vogli, Roberto
   Chandola, Tarani
   Marmot, Michael Gideon
TI Negative aspects of close relationships and heart disease
SO ARCHIVES OF INTERNAL MEDICINE
LA English
DT Article
ID SOCIAL SUPPORT; MARITAL QUALITY; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; FOLLOW-UP; DEPRESSIVE SYMPTOMS; RELATIVE IMPORTANCE;
   WHITEHALL-II; MORTALITY; HEALTH
AB Background: The aims of the study were to (1) analyze the association between negative aspects of close relationships and increased risk for coronary heart disease and (2) examine whether the association is stronger among women and people of lower social position.
   Methods: Prospective cohort study of 9011 British civil servants (6114 men and 2897 women). Negative aspects of close relationships and other social support measures (confiding/emotional and practical) were assessed with the Close Persons Questionnaire during phase 2 (1989-1990) or phase 1 (1985-1988). Associations between negative aspects of close relationships and incident coronary events were determined during an average follow-up period of 12.2 years. Covariates included sociodemographic characteristics (age, sex, marital status, and employment grade), biological factors (obesity, hypertension, diabetes mellitus, and cholesterol level), psychosocial factors (negative affectivity, depression, and work stress), and health behaviors (smoking, alcohol intake, exercise, and fruit and vegetable consumption).
   Results: After adjustment for sociodemographic characteristics, biological factors, and other dimensions of social support, individuals who experienced negative aspects of close relationships had a higher risk of incident coronary events (hazard ratio, 1.34; 95% confidence interval, 1.10-1.63). The association was attenuated but remained statistically significant after additional adjustment for negative affectivity and depression (hazard ratio, 1.25; 95% confidence interval, 1.02-1.55). Although women and men in a lower employment grade were more likely to be exposed to negative aspects of close relationships, sex and social position had no statistically significant interaction effects. Confiding/emotional and practical support were not associated with incident coronary events.
   Conclusion: Adverse close relationships may increase the risk of heart disease.
C1 UCL, Dept Epidemiol & Publ Hlth, Int Inst Soc & Hlth, London WC1E 6BT, England.
C3 University of London; University College London
RP De Vogli, R (corresponding author), UCL, Dept Epidemiol & Publ Hlth, Int Inst Soc & Hlth, 1-19 Torrington Pl, London WC1E 6BT, England.
EM r.devogli@ucl.ac.uk
RI Marmot, Michael/Y-3920-2019; Chandola, Tarani/I-3192-2013
OI Marmot, Michael/0000-0002-2431-6419; Chandola,
   Tarani/0000-0002-1864-3413
FU AHRQ HHS [HS 06516] Funding Source: Medline; British Heart Foundation
   [RG/07/008/23674] Funding Source: Medline; Medical Research Council
   [G19/35, G8802774, G0100222] Funding Source: Medline; NHLBI NIH HHS [HL
   36310] Funding Source: Medline; NIA NIH HHS [AG 13196] Funding Source:
   Medline
CR BERKMAN LF, 1979, AM J EPIDEMIOL, V109, P186, DOI 10.1093/oxfordjournals.aje.a112674
   Bookwala J, 2005, J AGING HEALTH, V17, P85, DOI 10.1177/0898264304272794
   Bradburn N.M., 1969, Aldine
   Coyne JC, 2001, AM J CARDIOL, V88, P526, DOI 10.1016/S0002-9149(01)01731-3
   Druley JA, 1998, HEALTH PSYCHOL, V17, P255
   Finch JF, 1999, J PERS, V67, P581, DOI 10.1111/1467-6494.00066
   Fuhrer R, 1999, SOC SCI MED, V48, P77, DOI 10.1016/S0277-9536(98)00290-1
   Goldberg D. P., 1972, The detection of psychiatric illness by questionnaire
   Hanson RL, 2002, DIABETES, V51, P3120, DOI 10.2337/diabetes.51.10.3120
   Hemingway H, 1999, BMJ-BRIT MED J, V318, P1460, DOI 10.1136/bmj.318.7196.1460
   Hemingway H, 2003, BRIT MED J, V327, P895, DOI 10.1136/bmj.327.7420.895
   HORWITZ AV, 1991, J HEALTH SOC BEHAV, V32, P221, DOI 10.2307/2136805
   HOUSE JS, 1988, SCIENCE, V241, P540, DOI 10.1037/0003-066X.59.8.676
   Johnson E.H., 1990, The deadly emotions: The role of anger, hostility, and aggression in health and emotional well-being
   Johnson NJ, 2000, ANN EPIDEMIOL, V10, P224, DOI 10.1016/S1047-2797(99)00052-6
   KAPLAN GA, 1988, AM J EPIDEMIOL, V128, P370, DOI 10.1093/oxfordjournals.aje.a114977
   Karasek R.A., 1990, Healthy work: stress, productivity, and the reconstruction of working life
   Kawachi I, 1996, J EPIDEMIOL COMMUN H, V50, P245, DOI 10.1136/jech.50.3.245
   Kiecolt-Glaser JK, 2001, PSYCHOL BULL, V127, P472, DOI 10.1037//0033-2909.127.4.472
   Krause N, 2006, INT J AGING HUM DEV, V62, P185, DOI 10.2190/7PVL-3YA2-A3QC-9M0B
   Krause N, 2005, J AGING HEALTH, V17, P28, DOI 10.1177/0898264304272782
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lett HS, 2005, PSYCHOSOM MED, V67, P869, DOI 10.1097/01.psy.0000188393.73571.0a
   Lincoln KD, 2005, J MARRIAGE FAM, V67, P754, DOI 10.1111/j.1741-3737.2005.00167.x
   MARMOT M, 2004, HOW YOUR SOCIAL STAN
   MARMOT MG, 1991, LANCET, V337, P1387, DOI 10.1016/0140-6736(91)93068-K
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   Newsom JT, 2005, J GERONTOL B-PSYCHOL, V60, pP304, DOI 10.1093/geronb/60.6.P304
   Newsom JT, 2003, PSYCHOL AGING, V18, P746, DOI 10.1037/0882-7974.18.4.746
   NOTARIUS CI, 1989, BEHAV ASSESS, V11, P39
   Orth-Gomér K, 2000, JAMA-J AM MED ASSOC, V284, P3008, DOI 10.1001/jama.284.23.3008
   PAGEL MD, 1987, J PERS SOC PSYCHOL, V53, P793, DOI 10.1037/0022-3514.53.4.793
   RAEL EGS, 1995, J EPIDEMIOL COMMUN H, V49, P474, DOI 10.1136/jech.49.5.474
   REAVEN GM, 1994, AM HEART J, V127, P1439, DOI 10.1016/0002-8703(94)90073-6
   Rook K., 2001, APPL DEV SCI, V5, P86, DOI [DOI 10.1207/S1532480XADS0502_4, 10.1207/S1532480XADS05024, DOI 10.1207/S1532480XADS05024]
   Rook KS, 1998, DARK SIDE OF CLOSE RELATIONSHIPS, P369
   Rosengren A, 2004, EUR HEART J, V25, P56, DOI 10.1016/j.ehj.2003.10.005
   STANSFELD S, 1992, SOC SCI MED, V35, P1027, DOI 10.1016/0277-9536(92)90242-I
   Stansfeld SA, 1998, PSYCHOSOM MED, V60, P247, DOI 10.1097/00006842-199805000-00004
   TAYLOR SE, 1991, PSYCHOL BULL, V110, P67, DOI 10.1037/0033-2909.110.1.67
   Troxel WM, 2005, ARCH INTERN MED, V165, P1022, DOI 10.1001/archinte.165.9.1022
   Umberson D, 2006, J HEALTH SOC BEHAV, V47, P1, DOI 10.1177/002214650604700101
NR 42
TC 126
Z9 160
U1 0
U2 10
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0003-9926
EI 1538-3679
J9 ARCH INTERN MED
JI Arch. Intern. Med.
PD OCT 8
PY 2007
VL 167
IS 18
BP 1951
EP 1957
DI 10.1001/archinte.167.18.1951
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA 217LC
UT WOS:000249948400005
PM 17923594
DA 2025-06-11
ER

PT J
AU Schmeda-Hirschmann, G
   Antileo-Laurie, J
   Theoduloz, C
   Jiménez-Aspee, F
   Avila, F
   Burgos-Edwards, A
   Olate-Olave, V
AF Schmeda-Hirschmann, Guillermo
   Antileo-Laurie, Javier
   Theoduloz, Cristina
   Jimenez-Aspee, Felipe
   Avila, Felipe
   Burgos-Edwards, Alberto
   Olate-Olave, Veronica
TI Phenolic composition, antioxidant capacity and α-glucosidase inhibitory
   activity of raw and boiled Chilean Araucaria araucana kernels
SO FOOD CHEMISTRY
LA English
DT Article
DE Araucaria araucana; Phenolics; Metabolic syndrome-associated enzymes;
   Antioxidant activity; Mapuche traditional food; HPLC-DAD-QTOF-MSn
AB The Araucaria araucana kernels are a traditional food in southern Chile and Argentina. The aim of this work was to determine the composition of the phenolic-enriched extracts (PEEs) of the boiled kernels as well as their antioxidant capacity, inhibitory activity on metabolic syndrome-associated enzymes and effect on postprandial oxidative stress in a simulated gastric digestion model. The PEEs composition was assessed by HPLC-DAD-MS/ MS. The main PEEs constituents were catechin and epicatechin in the unbound form, while hydroxybenzoic acids occurred mainly in the bound form. The unbound phenolics from boiled kernels showed significant correlations with DPPH, FRAP, TEAC (Pearson's r of 0.481, 0.331 and 0.417, respectively) and lipid peroxidation (r = 0.381) and were more active than the bound phenolics. The extracts were highly active against alpha-glucosidase (IC50: 0.33-3.15 mu g/mL) and reduced lipoperoxidation. Traditional processing increases the flavan-3-ol content. Our results suggest that this traditional food has potential health promoting properties.
C1 [Schmeda-Hirschmann, Guillermo; Antileo-Laurie, Javier; Burgos-Edwards, Alberto] Univ Talca, Inst Quim Recursos Nat, Lab Quim Prod Nat, Campus Lircay, Talca 3460000, Chile.
   [Theoduloz, Cristina] Univ Talca, Fac Ciencias Salud, Lab Cult Celular, Campus Lircay, Talca 3460000, Chile.
   [Jimenez-Aspee, Felipe] Univ Talca, Fac Ciencias Salud, Dept Ciencias Basicas Biomed, Campus Lircay, Talca 3460000, Chile.
   [Avila, Felipe] Univ Talca, Fac Ciencias Salud, Escuela Nutr & Dietet, Campus Lircay, Talca 3460000, Chile.
   [Olate-Olave, Veronica] Fraunhofer Chile Res, Ctr Syst Biotechnol, Ave Condor 844,Piso 3, Santiago, Chile.
   [Jimenez-Aspee, Felipe] Univ Hohenheim, Inst Nutr Sci, Dept Food Biofunctional, D-70599 Stuttgart, Germany.
   [Burgos-Edwards, Alberto] Univ Nacl Asuncion, Fac Ciencias Quim, Dept Fitoquim, Asuncion 1055, Paraguay.
C3 Universidad de Talca; Universidad de Talca; Universidad de Talca;
   Universidad de Talca; Fraunhofer Gesellschaft; Fraunhofer Chile;
   University Hohenheim; Universidad Nacional de Asuncion
RP Schmeda-Hirschmann, G (corresponding author), Univ Talca, Inst Quim Recursos Nat, Lab Quim Prod Nat, Campus Lircay, Talca 3460000, Chile.
EM schmeda@utalca.cl
RI Aspee, Felipe/ABA-2948-2020; Schmeda-Hirschmann, Guillermo/G-1046-2010
OI Burgos-Edwards, Alberto/0000-0001-8286-8556
FU FONDECYT, CORFO Fraunhofer Research Center [1170090]; CORFO FCR
   [CSB-09CEII-6991]; Universidad de Talca; ANID Beca Doctorado Nacional
   Ano Academico 2018 [21180359]; FONDEQUIP EQM [170023]
FX This work was supported by FONDECYT 1170090, CORFO Fraunhofer Research
   Center. Compuestos Bioactivos and CORFO FCR CSB-09CEII-6991; JA-L thanks
   the Universidad de Talca for a Doctoral grant during 2017 and ANID Beca
   Doctorado Nacional Ano Academico 2018 N. 21180359. We are grateful to
   the "Francisco Antileo Cau Cau" Mapuche community (Canete, Chile) for
   their help with the Pino Huacho samples. We thank FONDEQUIP EQM 170023
   for the HPLC-MS/MSn measurements. We thank Mrs. Rachael Jim ' enez-Lange
   (Lexsys Language Consulting, Germany) for the English revision.
CR Acosta-Estrada BA, 2014, FOOD CHEM, V152, P46, DOI 10.1016/j.foodchem.2013.11.093
   BERNFELD P, 1955, METHOD ENZYMOL, V1, P149, DOI 10.1016/0076-6879(55)01021-5
   Bravo-Arrepol G.A., 2018, M 33 JORN QUIM PUERT
   Chen PX, 2015, FOOD CHEM, V185, P298, DOI 10.1016/j.foodchem.2015.03.100
   Cordenunsi BR, 2004, J AGR FOOD CHEM, V52, P3412, DOI 10.1021/jf034814l
   Cremonini E, 2019, FREE RADICAL BIO MED, V130, P478, DOI 10.1016/j.freeradbiomed.2018.11.010
   da Silva SM, 2014, FOOD RES INT, V56, P1, DOI 10.1016/j.foodres.2013.12.004
   DArchivio M., 2018, Polyphenols: mechanisms of action in human health and disease, P181, DOI [DOI 10.1016/B978-0-12-813006-3.00014-3, 10.1016/B978-0- 12-813006-3.00014-3]
   Delgado AM, 2019, J AOAC INT, V102, P1356, DOI [10.1093/jaoac/102.5.1356, 10.5740/jaoacint.19-0128]
   Domínguez-Rodríguez G, 2017, J CHROMATOGR A, V1514, P1, DOI 10.1016/j.chroma.2017.07.066
   Eklund PC, 2008, J MASS SPECTROM, V43, P97, DOI 10.1002/jms.1276
   Figueroa F, 2017, INT J FOOD PROP, V20, P1074, DOI 10.1080/10942912.2016.1199036
   Fundacion para la Innovacion Agraria FIA Ministerio de Agricultura, 2010, RES LECC PROD TECN P
   Glensk M, 2013, BIOCHEM SYST ECOL, V46, P18, DOI 10.1016/j.bse.2012.09.002
   Henríquez C, 2008, FOOD CHEM, V107, P592, DOI 10.1016/j.foodchem.2007.08.040
   ICH Steering Committee, 2005, INT C HARM TECHN REQ, V4
   Jiménez-Aspee F, 2019, MOLECULES, V24, DOI 10.3390/molecules24224028
   Kadri N, 2015, FOOD CHEM, V188, P184, DOI 10.1016/j.foodchem.2015.04.138
   Kanner J, 2017, REDOX BIOL, V12, P929, DOI 10.1016/j.redox.2017.04.029
   Kim T, 2014, BIOORG MED CHEM LETT, V24, P1621, DOI 10.1016/j.bmcl.2014.01.027
   Koehnlein E. A., 2012, African Journal of Food Science, V6, P512
   Kwon E. Y., 2018, Clinical Nutrition, V37, pS146, DOI 10.1016/j.clnu.2018.06.1539
   Lin LZ, 2014, J AGR FOOD CHEM, V62, P9387, DOI 10.1021/jf501011y
   Lu YH, 2018, INT J FOOD PROP, V21, P2366, DOI 10.1080/10942912.2018.1522331
   Ma YY, 2014, J CHROMATOGR A, V1356, P64, DOI 10.1016/j.chroma.2014.06.027
   McDougall GJ, 2009, FOOD CHEM, V115, P193, DOI 10.1016/j.foodchem.2008.11.093
   Mosbach E.W., 1991, ARTE PRECOLOMBINO FU
   Oki T, 1999, J AGR FOOD CHEM, V47, P550, DOI 10.1021/jf980788t
   Padmanabhan P., 2016, Encyclopedia of food and health, P375
   Peng H, 2017, J FUNCT FOODS, V32, P296, DOI 10.1016/j.jff.2017.03.003
   Ramos LLP, 2019, FOOD CHEM, V298, DOI 10.1016/j.foodchem.2019.125026
   Popova IE, 2009, J CHROMATOGR A, V1216, P217, DOI 10.1016/j.chroma.2008.11.063
   Schmeda-Hirschmann G, 2019, J ETHNOPHARMACOL, V241, DOI 10.1016/j.jep.2019.111979
   Schmidt J, 2016, J MASS SPECTROM, V51, P33, DOI 10.1002/jms.3712
   Singleton VL, 1999, METHOD ENZYMOL, V299, P152
   Sousa JN, 2020, EXP GERONTOL, V134, DOI 10.1016/j.exger.2020.110881
   Vallverdú-Queralt A, 2010, RAPID COMMUN MASS SP, V24, P2986, DOI 10.1002/rcm.4731
   Wang YK, 2016, J FUNCT FOODS, V24, P359, DOI 10.1016/j.jff.2016.04.026
   Yamaguchi LF, 2009, PHYTOCHEMISTRY, V70, P615, DOI 10.1016/j.phytochem.2009.03.003
   Zhang B, 2015, FOOD CHEM, V172, P862, DOI 10.1016/j.foodchem.2014.09.144
   Zhang LL, 2019, BIOORG CHEM, V85, P364, DOI 10.1016/j.bioorg.2018.12.037
   Zhang YX, 2011, RAPID COMMUN MASS SP, V25, P2173, DOI 10.1002/rcm.5090
   Zuleta A, 2018, ITAL J FOOD SCI, V30, P170, DOI 10.14674/IJFS-996
NR 43
TC 15
Z9 15
U1 3
U2 55
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0308-8146
EI 1873-7072
J9 FOOD CHEM
JI Food Chem.
PD JUL 15
PY 2021
VL 350
AR 129241
DI 10.1016/j.foodchem.2021.129241
EA FEB 2021
PG 14
WC Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology; Nutrition & Dietetics
GA RB7MZ
UT WOS:000632293600008
PM 33601092
DA 2025-06-11
ER

PT J
AU Liu, JC
   Huang, ZJ
   Ma, WH
   Peng, SX
   Li, YM
   Miranda, KM
   Tian, JD
   Zhang, YH
AF Liu, Jingchao
   Huang, Zhangjian
   Ma, Wenhuan
   Peng, Sixun
   Li, Yunman
   Miranda, Katrina M.
   Tian, Jide
   Zhang, Yihua
TI Design and synthesis of rosiglitazone-ferulic acid-nitric oxide donor
   trihybrids for improving glucose tolerance
SO EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
DE Glucose intolerance; Rosiglitazone; Nitric oxide; Ferulic acid; Type 2
   diabetes mellitus
ID INDUCED INSULIN-RESISTANCE; NECROSIS-FACTOR-ALPHA; HEART-FAILURE;
   L-ARGININE; ANTIHYPERTENSIVE THERAPY; SIGNALING PATHWAYS; TROPONIN
   ELEVATION; OXIDATIVE STRESS; LOWERING DRUGS; BLOOD-PRESSURE
AB Glucose intolerance is associated with metabolic syndrome and type 2 diabetes mellitus (T2DM) while some new therapeutic drugs, such as rosiglitazone (Rosi), for T2DM can cause severe cardiovascular side effects. Herein we report the synthesis of Rosi-ferulic acid (FA)-nitric oxide (NO) donor trihybrids to improve glucose tolerance and minimize the side effects. In comparison with Rosi, the most active compound 21 exhibited better effects on improving glucose tolerance, which was associated with its NO production, antioxidant and anti-inflammatory activities. Furthermore, 21 displayed relatively high stability in the simulated gastrointestinal environments and human liver microsomes, and released Rosi in plasma. More importantly, 21, unlike Rosi, had little stimulatory effect on the membrane translocation of aquaporin-2 (AQP2) in kidney collecting duct epithelial cells. These, together with a better safety profile, suggest that the trihybrids, like 21, may be promising candidates for intervention of glucose intolerance-related metabolic syndrome and T2DM. (C) 2018 Published by Elsevier Masson SAS.
C1 [Liu, Jingchao; Huang, Zhangjian; Peng, Sixun; Zhang, Yihua] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China.
   [Liu, Jingchao; Huang, Zhangjian; Peng, Sixun; Zhang, Yihua] China Pharmaceut Univ, Jiangsu Key Lab Drug Discovery Metab Dis, Nanjing 210009, Jiangsu, Peoples R China.
   [Ma, Wenhuan; Li, Yunman] China Pharmaceut Univ, Dept Physiol, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China.
   [Miranda, Katrina M.] Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA.
   [Tian, Jide] Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA.
C3 China Pharmaceutical University; China Pharmaceutical University; China
   Pharmaceutical University; University of Arizona; University of
   California System; University of California Los Angeles
RP Zhang, YH (corresponding author), China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China.; Li, YM (corresponding author), China Pharmaceut Univ, Dept Physiol, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China.; Miranda, KM (corresponding author), Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA.
EM liyunman@cpu.edu.cn; kmiranda@email.arizona.edu; zyhtgd@163.com
RI Miranda, Katrina/B-7823-2009
OI Miranda, Katrina/0000-0002-9175-5091
FU National Natural Science Foundation of China [81822041, 81773573,
   81673305]; Jiangsu Province Funds for Distinguished Young Scientists
   [BK20160033]; Program for New Century Excellent Talents in University
   [NCET-13-1033]; National Institutes of Health [R01-GM076247]
FX This study was supported by grants from the National Natural Science
   Foundation of China (No. 81822041, No. 81773573 and No. 81673305) and
   Jiangsu Province Funds for Distinguished Young Scientists (BK20160033).
   Part of the work was supported by the Program for New Century Excellent
   Talents in University (NCET-13-1033) and the National Institutes of
   Health (R01-GM076247 to K.M.M.).
CR Abdul-Ghani MA, 2011, ENDOCR REV, V32, P515, DOI 10.1210/er.2010-0029
   Ahmadian M, 2013, NAT MED, V19, P557, DOI 10.1038/nm.3159
   Basudhar D, 2013, J MED CHEM, V56, P7804, DOI 10.1021/jm400196q
   Beltowski J, 2013, PPAR RES, V2013, DOI 10.1155/2013/628628
   Bogdanski P, 2012, EUR REV MED PHARMACO, V16, P816
   Borhade N, 2012, CHEM PHARM BULL, V60, P465, DOI 10.1248/cpb.60.465
   Bouley R, 2008, SEMIN NEPHROL, V28, P266, DOI 10.1016/j.semnephrol.2008.03.010
   Braga JR, 2013, CIRC-HEART FAIL, V6, P193, DOI 10.1161/CIRCHEARTFAILURE.112.000075
   Calderone V, 2009, BIOORGAN MED CHEM, V17, P5426, DOI 10.1016/j.bmc.2009.06.049
   Chen HP, 2009, EUR J PHARMACOL, V603, P86, DOI 10.1016/j.ejphar.2008.12.003
   Chen L, 2012, NAT REV ENDOCRINOL, V8, P228, DOI 10.1038/nrendo.2011.183
   Chen Y, 2012, J MED CHEM, V55, P4309, DOI 10.1021/jm300106z
   Choi HJ, 2015, AM J PHYSIOL-RENAL, V308, pF737, DOI 10.1152/ajprenal.00376.2014
   Cobitz A, 2008, PHARMACOEPIDEM DR S, V17, P769, DOI 10.1002/pds.1615
   Donath MY, 2014, NAT REV DRUG DISCOV, V13, P465, DOI 10.1038/nrd4275
   Dormandy JA, 2005, LANCET, V366, P1279, DOI 10.1016/S0140-6736(05)67528-9
   Evans JL, 2003, DIABETES, V52, P1, DOI 10.2337/diabetes.52.1.1
   Ferrannini E, 2012, LANCET, V380, P601, DOI 10.1016/S0140-6736(12)60987-8
   Foo B, 2016, J PHYSIOL-LONDON, V594, P2469, DOI 10.1113/JP270531
   Förstermann U, 2006, CIRCULATION, V113, P1708, DOI 10.1161/CIRCULATIONAHA.105.602532
   Fu JJ, 2013, J MED CHEM, V56, P4641, DOI 10.1021/jm400393u
   Gilbert RE, 2015, LANCET, V385, P2107, DOI 10.1016/S0140-6736(14)61402-1
   Gong QM, 2014, GENE, V539, P190, DOI 10.1016/j.gene.2014.02.012
   Gress TW, 2000, NEW ENGL J MED, V342, P905, DOI 10.1056/NEJM200003303421301
   Guan YF, 2005, NAT MED, V11, P861, DOI 10.1038/nm1278
   Gund M, 2014, BIOORG MED CHEM LETT, V24, P5587, DOI 10.1016/j.bmcl.2014.10.096
   Heijman J, 2014, CURR OPIN PHARMACOL, V15, P16, DOI 10.1016/j.coph.2013.11.004
   Hoang HH, 2013, CURR OPIN CLIN NUTR, V16, P76, DOI 10.1097/MCO.0b013e32835ad1ef
   Hoffmann LS, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms8235
   Holman RR, 2014, LANCET, V383, P2008, DOI 10.1016/S0140-6736(14)60794-7
   Home PD, 2005, DIABETOLOGIA, V48, P1726, DOI 10.1007/s00125-005-1869-1
   Hong Q, 2016, EUR J PHARMACOL, V777, P1, DOI 10.1016/j.ejphar.2016.01.005
   Hong SY, 2010, ACS MED CHEM LETT, V1, P386, DOI 10.1021/ml1000905
   HORTON ES, 1983, AM J MED, V75, P32, DOI 10.1016/0002-9343(83)90251-6
   HOTAMISLIGIL GS, 1994, P NATL ACAD SCI USA, V91, P4854, DOI 10.1073/pnas.91.11.4854
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Ignarro Louis J, 2005, Curr Diab Rep, V5, P17, DOI 10.1007/s11892-005-0062-8
   Ismail-Beigi F, 2012, NEW ENGL J MED, V366, P1319, DOI 10.1056/NEJMcp1013127
   Januzzi JL Jr, 2012, EUR HEART J, V33, P2265, DOI 10.1093/eurheartj/ehs191
   Juillerat-Jeanneret L, 2014, J MED CHEM, V57, P2197, DOI 10.1021/jm400658e
   Kaur J, 2012, J MED CHEM, V55, P7883, DOI 10.1021/jm300997w
   Keefer LK, 2011, ACS CHEM BIOL, V6, P1147, DOI 10.1021/cb200274r
   Klein HH, 2002, J HEPATOL, V37, P432, DOI 10.1016/S0168-8278(02)00217-9
   Kociol RD, 2010, J AM COLL CARDIOL, V56, P1071, DOI 10.1016/j.jacc.2010.06.016
   Kojima H, 1998, CHEM PHARM BULL, V46, P373
   Komajda M, 2010, EUR HEART J, V31, P824, DOI 10.1093/eurheartj/ehp604
   Kroder G, 1996, J CLIN INVEST, V97, P1471, DOI 10.1172/JCI118569
   Kung J, 2012, EXPERT OPIN DRUG SAF, V11, P565, DOI 10.1517/14740338.2012.691963
   Landmesser U, 2003, J CLIN INVEST, V111, P1201, DOI 10.1172/JCI200314172
   Li HG, 2014, ATHEROSCLEROSIS, V237, P208, DOI 10.1016/j.atherosclerosis.2014.09.001
   Lundberg JO, 2009, NAT CHEM BIOL, V5, P865, DOI 10.1038/nchembio.260
   Maciag AE, 2011, J MED CHEM, V54, P7751, DOI 10.1021/jm2004128
   Maeda H, 1995, Curr Top Microbiol Immunol, V196, P37
   Monti LD, 2013, METABOLISM, V62, P255, DOI 10.1016/j.metabol.2012.08.004
   Nemmani KVS, 2009, BIOORG MED CHEM LETT, V19, P5297, DOI 10.1016/j.bmcl.2009.07.142
   Oghlakian G, 2009, CARDIOL REV, V17, P10, DOI 10.1097/CRD.0b013e318190e72c
   Procino G, 2015, CELL PHYSIOL BIOCHEM, V35, P1070, DOI 10.1159/000373933
   Rosen ED, 2006, NAT REV MOL CELL BIO, V7, P885, DOI 10.1038/nrm2066
   Saavedra JE, 2000, J MED CHEM, V43, P261, DOI 10.1021/jm9903850
   Samuel VT, 2012, CELL, V148, P852, DOI 10.1016/j.cell.2012.02.017
   Sansbury BE, 2014, FREE RADICAL BIO MED, V73, P383, DOI 10.1016/j.freeradbiomed.2014.05.016
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Song J, 2004, J PHARMACOL EXP THER, V308, P426, DOI 10.1124/jpet.103.058008
   Sowers JR, 2000, NEW ENGL J MED, V342, P969, DOI 10.1056/NEJM200003303421310
   Tamboli Y, 2012, BIOORG MED CHEM LETT, V22, P3810, DOI 10.1016/j.bmcl.2012.03.103
   Tiwari S, 2008, PHARMACOL RES, V57, P383, DOI 10.1016/j.phrs.2008.03.013
   Trombino S, 2004, J AGR FOOD CHEM, V52, P2411, DOI 10.1021/jf0303924
   Tsytsarev V, 2012, J NEUROSCI METH, V203, P136, DOI 10.1016/j.jneumeth.2011.09.005
   Udell JA, 2015, LANCET DIABETES ENDO, V3, P356, DOI 10.1016/S2213-8587(15)00044-3
   Uysal KT, 1997, NATURE, V389, P610, DOI 10.1038/39335
   Vallon V, 2009, J AM SOC NEPHROL, V20, P721, DOI 10.1681/ASN.2008040415
   Velázquez C, 2005, J MED CHEM, V48, P4061, DOI 10.1021/jm050211k
   Wang XL, 2013, J MED CHEM, V56, P3078, DOI 10.1021/jm4001693
   Xu GG, 2015, BIOCHEMISTRY-US, V54, P7178, DOI 10.1021/acs.biochem.5b01074
   Yue YK, 2015, CIRCULATION, V132, P230, DOI 10.1161/CIRCULATIONAHA.115.009800
   Zhang H, 2005, P NATL ACAD SCI USA, V102, P9406, DOI 10.1073/pnas.0501744102
   Zhou L, 2013, AM J PHYSIOL-RENAL, V305, pF1491, DOI 10.1152/ajprenal.00004.2013
   Zou MH, 2002, J CLIN INVEST, V109, P817, DOI 10.1172/JCI200214442
NR 78
TC 7
Z9 7
U1 2
U2 41
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0223-5234
EI 1768-3254
J9 EUR J MED CHEM
JI Eur. J. Med. Chem.
PD JAN 15
PY 2019
VL 162
BP 650
EP 665
DI 10.1016/j.ejmech.2018.10.006
PG 16
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Pharmacology & Pharmacy
GA HI9GE
UT WOS:000456762500045
PM 30481687
DA 2025-06-11
ER

PT J
AU Averna, M
AF Averna, Maurizio
TI The effect of ezetimibe on NAFLD
SO ATHEROSCLEROSIS SUPPLEMENTS
LA English
DT Article
DE Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis;
   Cholesterol; Ezetimibe
ID FATTY LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; METABOLIC SYNDROME;
   CONTROLLED-TRIAL; EPIDEMIOLOGY; EFFICACY; THERAPY; ADULTS; OBESE; MICE
AB NAFLD has become the most common liver disorder in countries, where obesity, type 2 diabetes mellitus, dyslipidemia, and metabolic syndrome are common. The strong association between these conditions and the risk of cardiovascular disease make treatment crucial. Possible interventions for NAFLD target excess body weight, insulin resistance, inflammation, oxidative stress or intestinal lipid absorption. Administration of combination therapy with a statin plus ezetimibe, associated with lifestyle changes, may represent an effective strategy because of the strong reduction in low-density lipoprotein cholesterol levels. Combination therapy is often more effective, especially when complementary mechanisms of action are involved. Ezetimibe is effective and well tolerated in combination with a number of lipid lowering therapies, including statins, orlistat, and insulin-sensitizing agents. There is strong evidence from preclinical models to supporting the use of ezetimibe in this setting. Larger controlled trials are needed to confirm its effectiveness in patients with NAFLD, to establish the most efficacious combinations and to determine whether treatment can reverse fibrosis. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 Univ Palermo, Sch Med, Dept Internal Med & Med Specialties DIBIMIS, I-90145 Palermo, Italy.
C3 University of Palermo
RP Averna, M (corresponding author), Univ Palermo, Sch Med, Dept Internal Med & Med Specialties DIBIMIS, Via Vespro 141, I-90145 Palermo, Italy.
EM maurizio.averna@unipa.it
RI Averna, Maurizio/U-9527-2017
OI Averna, Maurizio/0000-0003-3558-9209
FU Aegerion; Genzyme; MSD; Roche; Kowa; Amgen; Astra Zeneca; Sanofi; MSD
   Italia Srl
FX Dr. Averna has received payments for the provision of:- Consulting
   services - Aegerion, Genzyme, MSD, Roche, Kowa, Amgen, Astra Zeneca,
   Sanofi.- Participation as a speaker at scientific congresses - Aegerion,
   AstraZeneca, MSD, Mediolanum, Sanofi, Amgen.This work was funded by an
   unrestricted grant by MSD Italia Srl. The sponsor had no role in
   reviewing the literature, drafting or reviewing the paper, or in the
   decision to submit the manuscript for publication. All views expressed
   are solely those of the author. The author would like to thank Editamed
   Srl for editorial assistance in the preparation of the manuscript.
CR Ahmed MH, 2010, DRUG DISCOV TODAY, V15, P590, DOI 10.1016/j.drudis.2010.06.007
   Angulo P, 2007, ALIMENT PHARM THER, V25, P883, DOI 10.1111/j.1365-2036.2007.03246.x
   Chan DC, 2010, DIABETES CARE, V33, P1134, DOI 10.2337/dc09-1765
   Clark JM, 2006, J CLIN GASTROENTEROL, V40, pS5
   Davies JP, 2005, J BIOL CHEM, V280, P12710, DOI 10.1074/jbc.M409110200
   Eguchi Y, 2012, J GASTROENTEROL, V47, P586, DOI 10.1007/s00535-012-0533-z
   Foster T, 2011, AM J GASTROENTEROL, V106, P71, DOI 10.1038/ajg.2010.299
   Marchesini G, 2011, EXPERT OPIN EMERG DR, V16, P121, DOI 10.1517/14728214.2011.531700
   Minervini MI, 2009, J HEPATOL, V50, P501, DOI 10.1016/j.jhep.2008.10.030
   Musso G, 2014, DIABETOLOGIA, V57, P850, DOI 10.1007/s00125-014-3192-1
   Musso G, 2013, PROG LIPID RES, V52, P175, DOI 10.1016/j.plipres.2012.11.002
   Musso G, 2011, CURR OPIN LIPIDOL, V22, P489, DOI 10.1097/MOL.0b013e32834c37ee
   Nadalin S, 2005, LIVER TRANSPLANT, V11, P980, DOI 10.1002/lt.20462
   Oishi T, 2012, BIOCHEM BIOPH RES CO, V422, P22, DOI 10.1016/j.bbrc.2012.04.087
   Park H, 2011, J GASTROENTEROL, V46, P101, DOI 10.1007/s00535-010-0291-8
   Patel JV, 2006, INT J CLIN PRACT, V60, P914, DOI 10.1111/j.1742-1241.2006.01023.x
   Schattenberg JM, 2011, CURR OPIN LIPIDOL, V22, P479, DOI 10.1097/MOL.0b013e32834c7cfc
   Subramanian S, 2011, J LIPID RES, V52, P1626, DOI 10.1194/jlr.M016246
   Takeshita Y, 2011, J HEPATOL, V54, pS346, DOI 10.1016/S0168-8278(11)60870-2
   Takeshita Y, 2014, DIABETOLOGIA, V57, P878, DOI 10.1007/s00125-013-3149-9
   Tran TT, 2006, J GASTROEN HEPATOL, V21, P381, DOI 10.1111/j.1440-1746.2005.03968.x
   Van Rooyen DM, 2013, J HEPATOL, V59, P144, DOI 10.1016/j.jhep.2013.02.024
   Vernon G, 2011, ALIMENT PHARM THER, V34, P274, DOI 10.1111/j.1365-2036.2011.04724.x
   Wang X, 2014, HEPATOL RES, V44, P102, DOI 10.1111/hepr.12092
   Yamagishi S, 2006, MED HYPOTHESES, V66, P844, DOI 10.1016/j.mehy.2005.08.022
   Yilmaz Y, 2012, SEMIN LIVER DIS, V32, P14, DOI 10.1055/s-0032-1306422
   Yoneda M, 2010, HEPATOL RES, V40, P566, DOI 10.1111/j.1872-034X.2010.00644.x
   Younossi ZM, 2012, MEDICINE, V91, P319, DOI 10.1097/MD.0b013e3182779d49
   Zheng SQ, 2008, EUR J PHARMACOL, V584, P118, DOI 10.1016/j.ejphar.2008.01.045
NR 29
TC 19
Z9 20
U1 0
U2 9
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1567-5688
EI 1878-5050
J9 ATHEROSCLEROSIS SUPP
JI Atheroscler. Suppl.
PD FEB
PY 2015
VL 17
BP 27
EP 34
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CB4QX
UT WOS:000349614000007
PM 25659874
DA 2025-06-11
ER

PT J
AU Mohyeldin, RH
   Abdelzaher, WY
   Sharata, EE
   Mohamed, HMA
   Ahmed, MYM
   Attia, JZ
   Atta, M
   Saleh, RK
   Ghallab, EA
   Marey, H
   Elrehany, MA
   Rofaeil, RR
AF Mohyeldin, Reham H.
   Abdelzaher, Walaa Yehia
   Sharata, Ehab E.
   Mohamed, Hamza M. A.
   Ahmed, Mohamed Y. M.
   Attia, Josef Zekry
   Atta, Medhat
   Saleh, Rabeh Khairy
   Ghallab, Elshimaa A.
   Marey, Heba
   Elrehany, Mahmoud A.
   Rofaeil, Remon Roshdy
TI Aprepitant boasted a protective effect against olanzapine-induced
   metabolic syndrome and its subsequent hepatic, renal, and ovarian
   dysfunction; Role of IGF1/p-AKT/FOXO1 and NFκB/IL-1β/TNF-α signaling
   pathways in female Wistar albino rats
SO BIOCHEMICAL PHARMACOLOGY
LA English
DT Article
DE MS; Hepatorenal injury; PCOS; Aprepitant; IGF 1; FOXO 1
ID SUBSTANCE-P; INSULIN-RESISTANCE; ATYPICAL ANTIPSYCHOTICS;
   GLUCOSE-METABOLISM; MELATONIN PROTECTS; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; RISK-FACTORS; WEIGHT-GAIN; PHOSPHORYLATION
AB Olanzapine-induced metabolic syndrome (MS) is a primary risk factor for insulin resistance, hepatorenal damage, and polycystic ovarian syndrome. The objective of the current study was to assess the protective effects of aprepitant (AP) against MS caused by olanzapine and the associated ovarian, renal, and liver dysfunction via modulation of IGF1/p-AKT/FOXO1 and NF kappa B/IL-1 beta/TNF-alpha signaling pathways. AP mitigated all biochemical and histopathological abnormalities induced by olanzapine and resulted in a significant reduction of serum HOMAIR, lipid profile parameters, and a substantial decrease in hepatic, renal, and ovarian MDA, IL -6, IL-1 beta, TNF-alpha, NF kappa B, and caspase 3. Serum AST, ALT, urea, creatinine, FSH, LH, and testosterone also decreased significantly by AP administration. The FOXO 1 signaling pathway was downregulated in the AP -treated group, while GSH, SOD, and HDL cholesterol levels were elevated.
C1 [Mohyeldin, Reham H.; Sharata, Ehab E.; Rofaeil, Remon Roshdy] Deraya Univ, Fac Pharm, Dept Pharmacol & Toxicol, Al Minya 61111, Egypt.
   [Abdelzaher, Walaa Yehia; Rofaeil, Remon Roshdy] Minia Univ, Fac Med, Dept Med Pharmacol, Al Minya 61519, Egypt.
   [Mohamed, Hamza M. A.; Ahmed, Mohamed Y. M.] Minia Univ, Fac Med, Dept Obstet & Gynecol, Al Minya 61519, Egypt.
   [Attia, Josef Zekry] Minia Univ, Fac Med, Dept Anesthesia & ICU, Al Minya 61519, Egypt.
   [Atta, Medhat] Minia Univ, Fac Med, Dept Anat, Al Minya 61519, Egypt.
   [Saleh, Rabeh Khairy] Minia Univ, Fac Med, Dept Pathol, Al Minya 61519, Egypt.
   [Ghallab, Elshimaa A.; Elrehany, Mahmoud A.] Deraya Univ, Fac Pharm, Dept Biochem, Al Minya 61111, Egypt.
   [Marey, Heba] Minia Univ, Fac Med, Dept Biochem, Al Minya 61519, Egypt.
C3 Deraya University; Egyptian Knowledge Bank (EKB); Minia University;
   Egyptian Knowledge Bank (EKB); Minia University; Egyptian Knowledge Bank
   (EKB); Minia University; Egyptian Knowledge Bank (EKB); Minia
   University; Egyptian Knowledge Bank (EKB); Minia University; Deraya
   University; Egyptian Knowledge Bank (EKB); Minia University
RP Sharata, EE (corresponding author), Deraya Univ, Fac Pharm, Dept Pharmacol & Toxicol, Al Minya 61111, Egypt.
EM reham.hassan@deraya.edu.eg; walaa.hamada@mu.edu.eg;
   ehab.essam@deraya.edu.eg; Rabeh.Saleh@mu.edu.eg;
   elshimaa.amir@deraya.edu.eg; heba.ebrahim@mu.edu.eg;
   Mahmoud.elrehany@deraya.edu.eg; remon.roshdy@deraya.edu
RI Sharata, Ehab/MFI-7414-2025; elrehany, mahmoud/LWK-7215-2024;
   Abdelzaher, Walaa Yehia/IWM-2772-2023; Khairy Saleh, Rabeh/KII-7980-2024
OI Khairy Saleh, Rabeh/0009-0007-6979-838X; Rofaeil,
   Remon/0000-0002-4550-7863
CR Aapro M, 2015, ONCOLOGIST, V20, P450, DOI 10.1634/theoncologist.2014-0229
   Abdelnaser M, 2024, N-S ARCH PHARMACOL, V397, P947, DOI 10.1007/s00210-023-02650-y
   Abdelnaser M, 2023, LIFE SCI, V320, DOI 10.1016/j.lfs.2023.121562
   Abdelsalam H.M., 2023, J. Adv. Vet. Res., V13, P1313
   Aboonabi A, 2020, FREE RADICAL BIO MED, V150, P30, DOI 10.1016/j.freeradbiomed.2020.02.004
   Aguirre GA, 2016, J TRANSL MED, V14, DOI 10.1186/s12967-015-0762-z
   Ardakanian A, 2022, IRAN J BASIC MED SCI, V25, P198, DOI [10.22038/ijbms.2022.58734.13047, 10.22038/IJBMS.2022.58734.13047]
   Ashraf S, 2019, EGYPTIAN J MED HUMAN, V20, DOI 10.1186/s43042-019-0031-4
   Bancroft J D., 2013, Bancroft's Theory and Practice of Histological Techniques, V7th
   Barrea L, 2018, NUTR RES REV, V31, P291, DOI 10.1017/S0954422418000136
   Biggs WH, 1999, P NATL ACAD SCI USA, V96, P7421, DOI 10.1073/pnas.96.13.7421
   Bo QJ, 2016, PSYCHIAT RES, V237, P257, DOI 10.1016/j.psychres.2016.01.031
   Cao XY, 2023, BMC CANCER, V23, DOI 10.1186/s12885-023-10954-8
   Chen CH, 2008, PROG NEURO-PSYCHOPH, V32, P925, DOI 10.1016/j.pnpbp.2007.11.013
   Choi S, 2007, LIFE SCI, V81, P1024, DOI 10.1016/j.lfs.2007.08.009
   Coyle C, 2019, MOL CELL ENDOCRINOL, V498, DOI 10.1016/j.mce.2019.110561
   Doretto L, 2020, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.00543
   Ermolenko E, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23126837
   Evers SS, 2010, PHARMACOL BIOCHEM BE, V97, P163, DOI 10.1016/j.pbb.2010.05.029
   Ferno J, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020571
   Galling B, 2016, JAMA PSYCHIAT, V73, P247, DOI 10.1001/jamapsychiatry.2015.2923
   Grattagliano I, 2008, J NUTR BIOCHEM, V19, P491, DOI 10.1016/j.jnutbio.2007.06.011
   Gunawan S, 2023, SAUDI PHARM J, V31, P351, DOI 10.1016/j.jsps.2023.01.003
   Guo CL, 2021, BIOMED PHARMACOTHER, V133, DOI 10.1016/j.biopha.2020.110912
   Guven S, 2010, FERTIL STERIL, V93, P1327, DOI 10.1016/j.fertnstert.2008.10.053
   Hafez HM, 2022, LIFE SCI, V294, DOI 10.1016/j.lfs.2022.120381
   Houseknecht KL, 2007, NEUROPSYCHOPHARMACOL, V32, P289, DOI 10.1038/sj.npp.1301209
   Huang P, 2016, MOL MED REP, V14, P5116, DOI 10.3892/mmr.2016.5880
   Ibrahim MA, 2014, EUR J PHARMACOL, V724, P204, DOI 10.1016/j.ejphar.2013.12.024
   Isaacson RH, 2020, J NUTR BIOCHEM, V81, DOI 10.1016/j.jnutbio.2020.108399
   Jiang YW, 2017, CNS DRUGS, V31, P319, DOI 10.1007/s40263-017-0421-4
   Karagiannides I, 2008, GASTROENTEROLOGY, V134, P747, DOI 10.1053/j.gastro.2007.12.032
   Karagiannides I, 2011, ENDOCRINOLOGY, V152, P4571, DOI 10.1210/en.2011-1170
   Karagiannides I, 2011, ENDOCRINOLOGY, V152, P2197, DOI 10.1210/en.2010-1345
   Karagiannides L, 2006, P NATL ACAD SCI USA, V103, P5207, DOI 10.1073/pnas.0600821103
   Khallaf WAI, 2023, LIFE SCI, V326, DOI 10.1016/j.lfs.2023.121789
   Kim DH, 2021, AGING DIS, V12, P1713, DOI 10.14336/AD.2021.0225
   Kim H, 2014, PSYCHOPHARMACOLOGY, V231, P4059, DOI 10.1007/s00213-014-3540-3
   Kose D, 2021, J PHARM PHARMACOL, V73, P1302, DOI 10.1093/jpp/rgab088
   Lai JP, 1998, J NEUROIMMUNOL, V86, P80, DOI 10.1016/S0165-5728(98)00025-3
   Leucht S, 2013, LANCET, V382, P951, DOI 10.1016/S0140-6736(13)60733-3
   Li ZQ, 2009, J PINEAL RES, V46, P365, DOI 10.1111/j.1600-079X.2009.00672.x
   Liu XP, 2019, ARTIF CELL NANOMED B, V47, P1628, DOI 10.1080/21691401.2019.1573177
   Matsuzaki H, 2003, P NATL ACAD SCI USA, V100, P11285, DOI 10.1073/pnas.1934283100
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mohamed MZ, 2022, ENVIRON TOXICOL PHAR, V95, DOI 10.1016/j.etap.2022.103940
   Mohyeldin RH, 2023, LIFE SCI, V334, DOI 10.1016/j.lfs.2023.122210
   Nestler JE, 1998, J CLIN ENDOCR METAB, V83, P2001, DOI 10.1210/jc.83.6.2001
   O'Connell T, 2002, J CLIN ENDOCR METAB, V87, P4356, DOI 10.1210/jc.2002-020343
   Park SD, 2015, BIOCHEM BIOPH RES CO, V464, P711, DOI 10.1016/j.bbrc.2015.07.008
   Patel R, 2018, REPRODUCTION, V155, P139, DOI [10.1530/REP-17-0584, 10.1530/rep-17-0584]
   Patro-Malysza J, 2014, CURR PHARM BIOTECHNO, V15, P32, DOI 10.2174/1389201015666140330192941
   Ranasinghe P, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4041-1
   Razavi BM, 2017, BIOMED PHARMACOTHER, V92, P726, DOI 10.1016/j.biopha.2017.05.113
   Riordan HJ, 2011, AM HEALTH DRUG BENEF, V4, P292
   Salmon AB, 2015, AM J PHYSIOL-ENDOC M, V308, pE545, DOI 10.1152/ajpendo.00558.2014
   Sener G, 2005, SURG TODAY, V35, P52, DOI 10.1007/s00595-004-2879-1
   Shah R, 2016, SAUDI PHARM J, V24, P698, DOI 10.1016/j.jsps.2015.06.006
   Singh R, 2020, LIFE SCI, V247, DOI 10.1016/j.lfs.2020.117442
   Smith G. C., 2011, Archives of Physiology and Biochemistry, V117, P241, DOI 10.3109/13813455.2011.576681
   Stogios N, 2023, J PSYCHIATR NEUROSCI, V48, pE99, DOI 10.1503/jpn.220200
   Sucquart IE, 2021, ENDOCRINOLOGY, V162, DOI 10.1210/endocr/bqab020
   Tansky MF, 2007, P NATL ACAD SCI USA, V104, P10691, DOI 10.1073/pnas.0703394104
   Un HR, 2020, EUR J PHARMACOL, V880, DOI 10.1016/j.ejphar.2020.173168
   Wang J, 2022, ADIPOCYTE, V11, P84, DOI 10.1080/21623945.2022.2026590
   Yang Y, 2022, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.811584
   Younatan Yamema, 2023, Oxidative Medicine and Cellular Longevity, V2023, P5648837, DOI 10.1155/2023/5648837
   Zhao XN, 2020, DRUG DES DEV THER, V14, P1943, DOI 10.2147/DDDT.S244099
   Zynda ER, 2019, CELL CYCLE, V18, P596, DOI 10.1080/15384101.2019.1578149
NR 69
TC 7
Z9 7
U1 2
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0006-2952
EI 1873-2968
J9 BIOCHEM PHARMACOL
JI Biochem. Pharmacol.
PD MAR
PY 2024
VL 221
AR 116020
DI 10.1016/j.bcp.2024.116020
EA JAN 2024
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA MQ5E9
UT WOS:001195099300001
PM 38237301
DA 2025-06-11
ER

PT J
AU Yang, XC
   Bhowmick, K
   Rao, SY
   Xiang, XY
   Ohshiro, K
   Amdur, RL
   Hassan, MI
   Mohammad, T
   Crandall, K
   Cifani, P
   Shetty, K
   Lyons, SK
   Merrill, JR
   Vegesna, AK
   John, S
   Latham, PS
   Crawford, JM
   Mishra, B
   Dasarathy, S
   Wang, XW
   Yu, H
   Wang, ZW
   Huang, H
   Krainer, AR
   Mishra, L
AF Yang, Xiaochun
   Bhowmick, Krishanu
   Rao, Shuyun
   Xiang, Xiyan
   Ohshiro, Kazufumi
   Amdur, Richard L.
   Hassan, Md. Imtaiyaz
   Mohammad, Taj
   Crandall, Keith
   Cifani, Paolo
   Shetty, Kirti
   Lyons, Scott K.
   Merrill, Joseph R.
   Vegesna, Anil K.
   John, Sahara
   Latham, Patricia S.
   Crawford, James M.
   Mishra, Bibhuti
   Dasarathy, Srinivasan
   Wang, Xin Wei
   Yu, Herbert
   Wang, Zhanwei
   Huang, Hai
   Krainer, Adrian R.
   Mishra, Lopa
TI Aldehydes alter TGF-β signaling and induce obesity and cancer
SO CELL REPORTS
LA English
DT Article
ID GROWTH-FACTOR-BETA; METABOLIC SYNDROME; OXIDATIVE STRESS; MECHANISMS;
   BETA-2-SPECTRIN; HYPERTENSION; PATHOGENESIS; INHIBITOR; GENOTYPES;
   PATHWAYS
AB Obesity and fatty liver diseases-metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH)-affect over one-third of the global population and are exacerbated in individuals with reduced functional aldehyde dehydrogenase 2 (ALDH2), observed in approximately 560 million people. Current treatment to prevent disease progression to cancer remains inadequate, requiring innovative approaches. We observe that Aldh2-'-- '- and Aldh2-'-Sptbn1+'-- '- Sptbn1 + '- mice develop phenotypes of human metabolic syndrome (MetS) and MASH with accumulation of endogenous aldehydes such as 4-hydroxynonenal (4-HNE). Mechanistic studies demonstrate aberrant transforming growth factor b (TGF-b) signaling through 4-HNE modification of the SMAD3 adaptor SPTBN1 (b2-spectrin) to pro- fibrotic and pro-oncogenic phenotypes, which is restored to normal SMAD3 signaling by targeting SPTBN1 with small interfering RNA (siRNA). Significantly, therapeutic inhibition of SPTBN1 blocks MASH and fibrosis in a human model and, additionally, improves glucose handling in Aldh2-'-- '- and Aldh2-'-Sptbn1+'-- '- Sptbn1 + '- mice. This study identifies SPTBN1 as a critical regulator of the functional phenotype of toxic aldehyde-induced MASH and a potential therapeutic target.
C1 [Yang, Xiaochun; Bhowmick, Krishanu; Xiang, Xiyan; Ohshiro, Kazufumi; Vegesna, Anil K.; John, Sahara; Mishra, Bibhuti; Mishra, Lopa] Inst Bioelect Med, Northwell Hlth, Feinstein Inst Med Res, Dept Med,Div Gastroenterol & Hepatol, Manhasset, NY 11030 USA.
   [Yang, Xiaochun; Bhowmick, Krishanu; Xiang, Xiyan; Cifani, Paolo; Lyons, Scott K.; Merrill, Joseph R.; Vegesna, Anil K.; John, Sahara; Krainer, Adrian R.; Mishra, Lopa] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA.
   [Rao, Shuyun; Mishra, Lopa] George Washington Univ, Dept Surg, Washington, DC 20037 USA.
   [Amdur, Richard L.] Inst Hlth Syst Sci & Bioelect Med, Northwell Hlth, Feinstein Inst Med Res, Quantitat Intelligence Unit, Manhasset, NY 11030 USA.
   [Hassan, Md. Imtaiyaz; Mohammad, Taj] Jamia Millia Islamia, Ctr Interdisciplinary Res Basic Sci, New Delhi 110025, India.
   [Crandall, Keith] George Washington Univ, Computat Biol Inst, Dept Biostat & Bioinformat, Washington, DC 20037 USA.
   [Shetty, Kirti] Univ Maryland, Sch Med, Dept Gastroenterol & Hepatol, Baltimore, MD 21201 USA.
   [Latham, Patricia S.] George Washington Univ, Dept Pathol, Washington, DC 20037 USA.
   [Crawford, James M.] Northwell Hlth, Donald & Barbara Zucker Sch Med Hofstra, Dept Pathol & Lab Med, Manhasset, NY 11030 USA.
   [Mishra, Bibhuti] Northwell Hlth, Dept Neurol, Manhasset, NY 11030 USA.
   [Dasarathy, Srinivasan] Cleveland Clin, Div Gastroenterol & Hepatol, Cleveland, OH 44106 USA.
   [Wang, Xin Wei] NCI, Ctr Canc Res, Liver Canc Program, Lab Human Carcinogenesis, Bethesda, MD 20892 USA.
   [Yu, Herbert; Wang, Zhanwei] Univ Hawaii Canc Ctr, Epidemiol Program, Honolulu, HI 96813 USA.
   [Huang, Hai] Northwell Hlth, Feinstein Inst Med Res, Ctr Immunol & Inflammat, Donald & Barbara Zucker Sch Med Hofstra, Manhasset, NY 11030 USA.
C3 Northwell Health; Cold Spring Harbor Laboratory; George Washington
   University; Northwell Health; Jamia Millia Islamia; George Washington
   University; University System of Maryland; University of Maryland
   Baltimore; George Washington University; Northwell Health; Northwell
   Health; Cleveland Clinic Foundation; National Institutes of Health (NIH)
   - USA; NIH National Cancer Institute (NCI); Cancer Research Center of
   Hawaii; Northwell Health
RP Mishra, L (corresponding author), Inst Bioelect Med, Northwell Hlth, Feinstein Inst Med Res, Dept Med,Div Gastroenterol & Hepatol, Manhasset, NY 11030 USA.; Mishra, L (corresponding author), Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA.; Mishra, L (corresponding author), George Washington Univ, Dept Surg, Washington, DC 20037 USA.
EM lopamishra2@gmail.com
RI Xiang, Xiyan/GLR-1454-2022; Amdur, Richard/AAE-5345-2019; Crandall,
   Keith/H-2789-2019; Yang, Xiaochun/CAG-2002-2022; Bhowmick,
   Krishanu/CEH-1458-2022; Huang, Hai/F-4286-2012; wang,
   zhanwei/A-3830-2013; Mohammad, Taj/HJH-1874-2023; Wang, Xin
   Wei/B-6162-2009
OI Wang, Xin Wei/0000-0001-9735-606X; Amdur, Richard/0000-0002-4900-653X
FU National Institutes of Health; United States-NIH/NIAAA [R01AA023146];
   NIH/NCI [R01CA236591, U01CA230690]; Elaine H. Snyder Cancer Research
   award
FX We thank Dr. Agata Smogorzewska from Rockefeller University for the
   Aldh2-/-mice. We thank Drs. Zhanhuai Wang, Sobia Zaidi, and Wilma
   Jogunoori for technical support. We thank Dr. Gareth Guenigault's
   support with assays in the 3D human MASH co-culture model. We thank Dr.
   Nancy R. Gough for intellectual input and manuscript editing. This
   research was supported by National Institutes of Health, United
   States-NIH/NIAAA grant R01AA023146 (L.M.) , NIH/NCI grants R01CA236591
   (L.M.) , U01CA230690 (L.M.) , and an Elaine H. Snyder Cancer Research
   award (L.M.) .
CR Armani A, 2017, FASEB J, V31, P4240, DOI 10.1096/fj.201601125RRR
   Baek HJ, 2016, INT J BIOL SCI, V12, P172, DOI 10.7150/ijbs.13420
   Bellomo C, 2016, BRIT J CANCER, V115, P761, DOI 10.1038/bjc.2016.255
   Boyle AP, 2012, GENOME RES, V22, P1790, DOI 10.1101/gr.137323.112
   Chang JS, 2017, J BIOMED SCI, V24, DOI 10.1186/s12929-017-0327-y
   Chang YC, 2023, NAT COMMUN, V14, DOI 10.1038/s41467-023-41570-6
   Chapple SJ, 2013, REDOX BIOL, V1, P319, DOI 10.1016/j.redox.2013.04.001
   Cheema AK, 2014, J PROTEOME RES, V13, P3065, DOI 10.1021/pr500278t
   Chen CH, 2020, EBIOMEDICINE, V55, DOI 10.1016/j.ebiom.2020.102753
   Chen J, 2018, GASTROENTEROLOGY, V154, P195, DOI 10.1053/j.gastro.2017.09.007
   Chen J, 2017, HEPATOLOGY, V65, P678, DOI 10.1002/hep.28927
   Chen J, 2016, J CLIN INVEST, V126, P527, DOI 10.1172/JCI80937
   Chen Z, 2020, FREE RADICAL BIO MED, V152, P116, DOI 10.1016/j.freeradbiomed.2020.02.025
   Cheng HZ, 2020, GENE, V758, DOI 10.1016/j.gene.2020.144966
   Cousin MA, 2021, NAT GENET, V53, P1006, DOI 10.1038/s41588-021-00886-z
   CRABB DW, 1989, J CLIN INVEST, V83, P314, DOI 10.1172/JCI113875
   Davies SS, 2014, CHEM PHYS LIPIDS, V181, P1, DOI 10.1016/j.chemphyslip.2014.03.002
   de la Fuente M, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22179181
   Dingler FA, 2020, MOL CELL, V80, P996, DOI 10.1016/j.molcel.2020.10.012
   Eng MY, 2007, ALCOHOL RES HEALTH, V30, P22
   Fiser A, 2003, BIOINFORMATICS, V19, P2500, DOI 10.1093/bioinformatics/btg362
   Gao YH, 2019, GUT, V68, P1311, DOI 10.1136/gutjnl-2018-316221
   Goldin A, 2006, CIRCULATION, V114, P597, DOI 10.1161/CIRCULATIONAHA.106.621854
   Guex N, 1997, ELECTROPHORESIS, V18, P2714, DOI 10.1002/elps.1150181505
   Guillot A, 2019, P NATL ACAD SCI USA, V116, P25974, DOI 10.1073/pnas.1908137116
   Harrison SA, 2023, NAT MED, V29, P562, DOI 10.1038/s41591-023-02242-6
   Hossain Z, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-27018-8
   Huang DIQ, 2021, NAT REV GASTRO HEPAT, V18, P223, DOI 10.1038/s41575-020-00381-6
   Korkut A, 2018, CELL SYST, V7, P422, DOI 10.1016/j.cels.2018.08.010
   Kostrzewski T, 2020, HEPATOL COMMUN, V4, P77, DOI 10.1002/hep4.1450
   Kwon YJ, 2020, NUTRIENTS, V12, DOI 10.3390/nu12092580
   Li YC, 2024, bioRxiv, DOI [10.1101/2023.07.10.548398, 10.1101/2023.07.10.548398, DOI 10.1101/2023.07.10.548398]
   Libiseller G, 2015, BMC BIOINFORMATICS, V16, DOI 10.1186/s12859-015-0562-8
   Lin E, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-14025-4
   Liu SJ, 2021, SIGNAL TRANSDUCT TAR, V6, DOI 10.1038/s41392-020-00436-9
   Lonardo A, 2018, J HEPATOL, V68, P335, DOI 10.1016/j.jhep.2017.09.021
   Matsuura I, 2004, NATURE, V430, P226, DOI 10.1038/nature02650
   Mohammad T, 2021, BRIEF BIOINFORM, V22, DOI 10.1093/bib/bbaa279
   Morris GM, 2009, J COMPUT CHEM, V30, P2785, DOI 10.1002/jcc.21256
   Nikolic I, 2020, NAT REV ENDOCRINOL, V16, P697, DOI 10.1038/s41574-020-00418-5
   Noble PW, 2011, LANCET, V377, P1760, DOI 10.1016/S0140-6736(11)60405-4
   Oikonomou D, 2018, EUR J GASTROEN HEPAT, V30, P979, DOI 10.1097/MEG.0000000000001191
   Pan Q, 2023, DIABETES, V72, DOI 10.2337/db23-0180
   Pang YL, 2013, CANCER DISCOV, V3, P936, DOI 10.1158/2159-8290.CD-12-0527
   Pang ZQ, 2021, NUCLEIC ACIDS RES, V49, pW388, DOI 10.1093/nar/gkab382
   Perez-Miller S, 2010, NAT STRUCT MOL BIOL, V17, P159, DOI 10.1038/nsmb.1737
   Petersen M, 2008, KIDNEY INT, V73, P705, DOI 10.1038/sj.ki.5002717
   Pham VN, 2023, SCIENCE, V382, DOI 10.1126/science.abp9201
   Prince JT, 2006, ANAL CHEM, V78, P6140, DOI 10.1021/ac0605344
   Rao SY, 2021, SCI TRANSL MED, V13, DOI 10.1126/scitranslmed.abk2267
   Roy D, 2022, STAR PROTOC, V3, DOI 10.1016/j.xpro.2022.101518
   Sasser TA, 2012, JOVE-J VIS EXP, DOI 10.3791/3680
   Schneider C, 2001, J BIOL CHEM, V276, P20831, DOI 10.1074/jbc.M101821200
   Schwabe RF, 2020, GASTROENTEROLOGY, V158, P1913, DOI 10.1053/j.gastro.2019.11.311
   Seo W, 2019, J HEPATOL, V71, P1000, DOI 10.1016/j.jhep.2019.06.018
   Spracklen CN, 2020, NATURE, V582, P240, DOI 10.1038/s41586-020-2263-3
   Suda T, 2007, GENE THER, V14, P129, DOI 10.1038/sj.gt.3302865
   Suo C, 2019, J THORAC ONCOL, V14, P712, DOI 10.1016/j.jtho.2018.12.023
   Tan P, 2018, JOVE-J VIS EXP, DOI 10.3791/57026
   Tang Y, 2005, CANCER RES, V65, P4228, DOI 10.1158/0008-5472.CAN-04-4585
   Tang Y, 2003, SCIENCE, V299, P574, DOI 10.1126/science.1075994
   Voelker J, 2017, J AM SOC NEPHROL, V28, P953, DOI 10.1681/ASN.2015111230
   Vujovic N, 2022, CELL METAB, V34, P1486, DOI 10.1016/j.cmet.2022.09.007
   Walton KL, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00461
   Wang HH, 2020, PEDIATR GASTROENTERO, V23, P189
   Wang YP, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21062061
   Wang ZW, 2021, JGH OPEN, V5, P1363, DOI 10.1002/jgh3.12682
   Xiang Xiyan, 2024, Genes Cancer, V15, P1, DOI 10.18632/genesandcancer.234
   Yadav H, 2011, CELL METAB, V14, P67, DOI 10.1016/j.cmet.2011.04.013
   Yang L, 2014, HEPATOLOGY, V59, P483, DOI 10.1002/hep.26698
   Yang PY, 2021, INT J BIOL SCI, V17, P32, DOI 10.7150/ijbs.52375
   Yu HS, 2009, TOXICOL MECH METHOD, V19, P535, DOI 10.3109/15376510903401708
   Yu L, 2002, EMBO J, V21, P3749, DOI 10.1093/emboj/cdf366
   Zhao JF, 2022, HEPATOL COMMUN, V6, P1301, DOI 10.1002/hep4.1892
   Zhi XL, 2015, HEPATOLOGY, V61, P598, DOI 10.1002/hep.27558
   Zhu YM, 2017, J CELL MOL MED, V21, P1106, DOI 10.1111/jcmm.13042
NR 76
TC 4
Z9 4
U1 0
U2 3
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 2211-1247
J9 CELL REP
JI Cell Reports
PD SEP 24
PY 2024
VL 43
IS 9
AR 114676
DI 10.1016/j.celrep.2024.114676
EA AUG 2024
PG 24
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA F0D6M
UT WOS:001306617900001
PM 39217614
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Braescu, L
   Gaspar, M
   Buriman, D
   Aburel, OM
   Merce, AP
   Bratosin, F
   Aleksandrovich, KS
   Alambaram, S
   Mornos, C
AF Braescu, Laurentiu
   Gaspar, Marinica
   Buriman, Darius
   Aburel, Oana Maria
   Merce, Adrian-Petru
   Bratosin, Felix
   Aleksandrovich, Klokov Sergei
   Alambaram, Satish
   Mornos, Cristian
TI The Role and Implications of Epicardial Fat in Coronary Atherosclerotic
   Disease
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE epicardial fat; atherosclerosis; coronary artery disease; metabolic
   syndrome; oxidative stress
ID PERIVASCULAR ADIPOSE-TISSUE; PERICARDIAL FAT; ARTERY-DISEASE; THICKNESS;
   ASSOCIATION; EXPRESSION; HEART
AB The current minireview aims to assess the implications of epicardial fat secretory function in the development of coronary artery disease. The epicardial adipose tissue (EAT) is a visceral fat depot that has been described as a cardiovascular risk factor. In addition to its mechanical protection role and physiological secretory function, it seems that various secretion products of the epicardial fat are responsible for metabolic disturbances at the level of the cardiac muscle when in association with pre-existing pathological conditions, such as metabolic syndrome. There is a pathological reduction in sarcomere shortening, abnormal cytosolic Ca2+ fluxes, reduced expression of sarcoplasmic endoplasmic reticulum ATPase 2a and decreased insulin-mediated Akt-Ser473-phosphorylation in association with abnormal levels of epicardial fat tissue. Activin A, angiopoietin-2, and CD14-positive monocytes selectively accumulate in the diseased myocardium, resulting in reduced cardiomyocyte contractile function. At the same time, it is believed that these alterations in secretory products directly decrease the myocyte function via molecular changes, thus contributing to the development of coronary disease when certain comorbidities are associated.
C1 [Braescu, Laurentiu; Gaspar, Marinica; Buriman, Darius; Merce, Adrian-Petru] Victor Babes Univ Med & Pharm, Dept Cardiovasc Surg, Timisoara 300041, Romania.
   [Aburel, Oana Maria] Victor Babes Univ Med & Pharm, Dept Funct Sci Pathophysiol, Fac Med, Timisoara 300041, Romania.
   [Aburel, Oana Maria] Victor Babes Univ Med & Pharm, Ctr Translat Res & Syst Med, Timisoara 300041, Romania.
   [Bratosin, Felix] Victor Babes Univ Med & Pharm, Dept Infect Dis, Methodol & Infect Dis Res Ctr, Timisoara 300041, Romania.
   [Aleksandrovich, Klokov Sergei] NV Sklifosovsky Res Inst Emergency Med, Bolshaya Sukharevskaya Ploshchad 3, Moscow 129090, Russia.
   [Alambaram, Satish] Bhaskar Med Coll, Amdapur Rd 156-162, Hyderabad 500075, India.
   [Mornos, Cristian] Victor Babes Univ Med & Pharm, Discipline Cardiol, Eftimie Murgu Sq 2, Timisoara 300041, Romania.
C3 Victor Babes University of Medicine & Pharmacy, Timisoara; Victor Babes
   University of Medicine & Pharmacy, Timisoara; Victor Babes University of
   Medicine & Pharmacy, Timisoara; Victor Babes University of Medicine &
   Pharmacy, Timisoara; Victor Babes University of Medicine & Pharmacy,
   Timisoara
RP Aburel, OM (corresponding author), Victor Babes Univ Med & Pharm, Dept Funct Sci Pathophysiol, Fac Med, Timisoara 300041, Romania.; Aburel, OM (corresponding author), Victor Babes Univ Med & Pharm, Ctr Translat Res & Syst Med, Timisoara 300041, Romania.
EM oanaduicu@umft.ro
RI Braescu, Laurentiu/HZK-8517-2023; Mornoş, Cristian/AHC-6893-2022;
   Bratosin, Felix/HDN-8724-2022; Buriman, Darius/KVB-8099-2024; Aburel,
   Oana/I-7658-2016
OI Braescu, Laurentiu/0000-0002-1658-7526; Bratosin,
   Felix/0000-0003-4711-4315; Buriman, Darius/0009-0005-3752-2122
FU Victor Babes University of Medicine and Pharmacy Grant
   [MITO-MB-CURAT:2POSTDOC/1387/03.02.2020]
FX Research supported by Victor Babes University of Medicine and Pharmacy
   Grant MITO-MB-CURAT:2POSTDOC/1387/03.02.2020.
CR Anumonwo JMB, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00002
   Baker AR, 2009, J CLIN ENDOCR METAB, V94, P261, DOI 10.1210/jc.2007-2579
   Bertaso AG, 2013, ARQ BRAS CARDIOL, V101, pE18
   Company JM, 2010, J APPL PHYSIOL, V109, P1904, DOI 10.1152/japplphysiol.00621.2010
   Corradi D, 2004, CARDIOVASC PATHOL, V13, P313, DOI 10.1016/j.carpath.2004.08.005
   Cosson E, 2021, CARDIOVASC DIABETOL, V20, DOI 10.1186/s12933-021-01225-6
   Daude P, 2022, DIAGNOSTICS, V12, DOI 10.3390/diagnostics12010126
   Dey D, 2012, CARDIOVASC DIAGN THE, V2, P85, DOI 10.3978/j.issn.2223-3652.2012.04.03
   Eroglu S, 2009, NUTR METAB CARDIOVAS, V19, P211, DOI 10.1016/j.numecd.2008.05.002
   Gorter PM, 2008, AM J CARDIOL, V102, P380, DOI 10.1016/j.amjcard.2008.04.002
   Gorter PM, 2008, ATHEROSCLEROSIS, V197, P896, DOI 10.1016/j.atherosclerosis.2007.08.016
   Gruzdeva OV, 2022, J PERS MED, V12, DOI 10.3390/jpm12020129
   Guglielmo M, 2021, ATHEROSCLEROSIS, V321, P30, DOI 10.1016/j.atherosclerosis.2021.02.008
   Hendricks S, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000028060
   Iacobellis G, 2005, NAT CLIN PRACT CARD, V2, P536, DOI 10.1038/ncpcardio0319
   Iacobellis G, 2009, HORM METAB RES, V41, P855, DOI 10.1055/s-0029-1231081
   Iacobellis G, 2009, HORM METAB RES, V41, P227, DOI 10.1055/s-0028-1100412
   Iacobellis G, 2008, CURR DIABETES REP, V8, P20, DOI 10.1007/s11892-008-0005-2
   Iacobellis G, 2008, OBESITY, V16, P887, DOI 10.1038/oby.2008.6
   Iacobellis G, 2011, TRENDS ENDOCRIN MET, V22, P450, DOI 10.1016/j.tem.2011.07.003
   Iacobellis G, 2009, J AM SOC ECHOCARDIOG, V22, P1311, DOI 10.1016/j.echo.2009.10.013
   Iacobellis G, 2009, OBESITY, V17, P625, DOI 10.1038/oby.2008.575
   Iwasaki K, 2011, CLIN CARDIOL, V34, P166, DOI 10.1002/clc.20840
   Kim JE, 2022, MOLECULES, V27, DOI 10.3390/molecules27020334
   Krishnan A, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10092501
   Lee JW, 2021, FRONT PEDIATR, V9, DOI 10.3389/fped.2021.745805
   Malavazos AE, 2010, AM J CARDIOL, V105, P1831, DOI 10.1016/j.amjcard.2010.01.368
   MARCHINGTON JM, 1989, COMP BIOCHEM PHYS B, V94, P225, DOI 10.1016/0305-0491(89)90337-4
   Mazurek T, 2003, CIRCULATION, V108, P2460, DOI 10.1161/01.CIR.0000099542.57313.C5
   Oda S, 2019, CURR CARDIOL REV, V15, P24, DOI 10.2174/1573403X14666180918102031
   Pabon MA, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01752
   Patel VB, 2017, HEART FAIL REV, V22, P889, DOI 10.1007/s10741-017-9644-1
   Pezeshkian M, 2009, METAB SYNDR RELAT D, V7, P125, DOI 10.1089/met.2008.0056
   Prati F, 2003, EUR HEART J, V24, P329, DOI 10.1016/S0195-668X(02)00426-8
   Rabkin SW, 2007, OBES REV, V8, P253, DOI 10.1111/j.1467-789X.2006.00293.x
   Rodríguez A, 2007, ENDOCRINOLOGY, V148, P324, DOI 10.1210/en.2006-0940
   Sacks HS, 2007, AM HEART J, V153, P907, DOI 10.1016/j.ahj.2007.03.019
   Salgado-Somoza A, 2012, CLIN ENDOCRINOL, V76, P51, DOI 10.1111/j.1365-2265.2011.04140.x
   Saura D, 2010, INT J CARDIOL, V141, P311, DOI 10.1016/j.ijcard.2008.11.127
   Schlett CL, 2012, ATHEROSCLEROSIS, V222, P129, DOI 10.1016/j.atherosclerosis.2012.02.029
   Stanley WC, 2005, PHYSIOL REV, V85, P1093, DOI 10.1152/physrev.00006.2004
   Verhagen SN, 2011, ATHEROSCLEROSIS, V214, P3, DOI 10.1016/j.atherosclerosis.2010.05.034
   Yafei S, 2019, DIABETES VASC DIS RE, V16, P378, DOI 10.1177/1479164119827602
   Yu WJ, 2021, J AM HEART ASSOC, V10, DOI 10.1161/JAHA.120.018080
NR 44
TC 15
Z9 15
U1 2
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD AUG
PY 2022
VL 11
IS 16
AR 4718
DI 10.3390/jcm11164718
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 4B2WQ
UT WOS:000845644900001
PM 36012956
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mauro, C
   De Rosa, V
   Marelli-Berg, F
   Solito, E
AF Mauro, Claudio
   De Rosa, Veronica
   Marelli-Berg, Federica
   Solito, Egle
TI Metabolic syndrome and the immunological affair with the blood-brain
   barrier
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE blood-brain barrier; metabolism; immune response; leukocytes; diet
ID ADVANCE TRANSLATIONAL RESEARCH; IMMUNE SURVEILLANCE; CALORIC
   RESTRICTION; T-CELLS; LEPTIN; OBESITY; CNS; ACTIVATION; HEALTH;
   NEUROINFLAMMATION
AB Epidemiological studies reveal an increased incidence of obesity world wide, which is associated with increased prevalence and severity of cognitive disorders. The blood-brain barrier (BBB) represents the interface between the peripheral circulation and the brain, and plays a fundamental role in the crosstalk between these two compartments. The homeostatic function of the BBB is the protection of the brain from peripheral insult/inflammation. Alterations in the function of the BBB lead to pathologies of the central nervous system. Recently, metabolic imbalance has been shown to be an important risk factor associated with the decline of BBB integrity and function. This has direct etiological consequences on a variety of cerebrovascular and neurodegenerative pathologies with great impact to society. Priority areas for future preclinical research include strategies to improve clinicians' ability to diagnose, prevent, and manage BBB abnormalities. In sharp contrast with epidemiological studies and clinical needs, little is known about the mechanisms that link metabolic syndrome to BBB functionality and cognitive disorders. Our view is that immune responses caused by metabolic stress might play a major role in this conundrum.
C1 [Mauro, Claudio; Marelli-Berg, Federica; Solito, Egle] Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London EC1M 6BQ, England.
   [De Rosa, Veronica] CNR, IEOS, Ist Endocrinol & Oncol Sperimentale G Salvatore, I-80125 Naples, Italy.
C3 University of London; Queen Mary University London; Consiglio Nazionale
   delle Ricerche (CNR); Istituto per Endocrinologia e Oncologia "Gaetano
   Salvatore" (IEOS-CNR)
RP Solito, E (corresponding author), Queen Mary Univ London, Barts & London Sch Med & Dent, Ctr Translat Med & Therapeut, William Harvey Res Inst, John Vane Bldg,Charterhouse Sq, London EC1M 6BQ, England.
EM e.solito@qmul.ac.uk
RI ; De Rosa, Veronica/K-6534-2016; Mauro, Claudio/AAN-1848-2021
OI Solito, Egle/0000-0001-5279-0049; De Rosa, Veronica/0000-0002-9477-0991;
   Mauro, Claudio/0000-0002-3736-0099
FU British Heart Foundation [FS/12/38/29640]; Ministero della Salute
   [GR-2010-2315414]; FIRB grant [RBFR12I3UB-004]; BHF Programme
   [RG/14/2/30616]; ARUK grant [PPG2013B-2]; Wellcome Trust [085123]
FX The authors are grateful to their respective sponsors for their support:
   the British Heart Foundation Fellowship FS/12/38/29640 to Claudio Mauro;
   Ministero della Salute grant GR-2010-2315414 and FIRB grant
   RBFR12I3UB-004 to Veronica De Rosa; BHF Programme grant RG/14/2/30616 to
   Federica Marelli-Berg; ARUK grant PPG2013B-2 and Wellcome Trust grant
   085123 to Egle Solito.
CR Abbott NJ, 2010, NEUROBIOL DIS, V37, P13, DOI 10.1016/j.nbd.2009.07.030
   Abbott NJ, 2006, NAT REV NEUROSCI, V7, P41, DOI 10.1038/nrn1824
   Arima Y, 2012, CELL, V148, P447, DOI 10.1016/j.cell.2012.01.022
   Arumugam TV, 2010, ANN NEUROL, V67, P41, DOI 10.1002/ana.21798
   Banks WA, 1996, PEPTIDES, V17, P305, DOI 10.1016/0196-9781(96)00025-3
   Banks WA, 2012, PHARMACOL THERAPEUT, V136, P82, DOI 10.1016/j.pharmthera.2012.07.006
   Banks WA, 2009, BMC NEUROL, V9, DOI 10.1186/1471-2377-9-S1-S3
   Banks WA, 2010, NEUROBIOL DIS, V37, P26, DOI 10.1016/j.nbd.2009.07.031
   Betsholtz C, 2014, NATURE, V509, P432, DOI 10.1038/nature13339
   Boraldi F, 2003, PROTEOMICS, V3, P917, DOI 10.1002/pmic.200300386
   Burguera B, 2000, DIABETES, V49, P1219, DOI 10.2337/diabetes.49.7.1219
   Cao HM, 2014, J ENDOCRINOL, V220, pT47, DOI 10.1530/JOE-13-0339
   Carvey PM, 2009, J NEUROCHEM, V111, P291, DOI 10.1111/j.1471-4159.2009.06319.x
   Crane PK, 2013, NEW ENGL J MED, V369, P540, DOI [10.1056/NEJMoa1215740, 10.1056/NEJMc1311765]
   Cristante E, 2013, P NATL ACAD SCI USA, V110, P832, DOI 10.1073/pnas.1209362110
   Daneman R, 2012, ANN NEUROL, V72, P648, DOI 10.1002/ana.23648
   De Giorgis V, 2013, SEIZURE-EUR J EPILEP, V22, P803, DOI 10.1016/j.seizure.2013.07.003
   De Rosa V, 2006, J CLIN INVEST, V116, P447, DOI 10.1172/JCI26523
   De Rosa V, 2007, IMMUNITY, V26, P241, DOI 10.1016/j.immuni.2007.01.011
   Engelhardt B, 2011, FLUIDS BARRIERS CNS, V8, DOI 10.1186/2045-8118-8-4
   Erickson MA, 2012, NEUROIMMUNOMODULAT, V19, P121, DOI 10.1159/000330247
   Frauwirth KA, 2002, IMMUNITY, V16, P769, DOI 10.1016/S1074-7613(02)00323-0
   Gräff J, 2013, J NEUROSCI, V33, P8951, DOI 10.1523/JNEUROSCI.5657-12.2013
   Hsu TM, 2014, FRONT AGING NEUROSCI, V6, DOI 10.3389/fnagi.2014.00088
   Ifergan I, 2011, BRAIN, V134, P3557, DOI 10.1093/brain/awr268
   Ishida H, 2006, AM J HYPERTENS, V19, P33, DOI 10.1016/j.amjhyper.2005.06.023
   Jones RG, 2007, IMMUNITY, V27, P173, DOI 10.1016/j.immuni.2007.07.008
   Kalaria RN, 1999, ANN NY ACAD SCI, V893, P113, DOI 10.1111/j.1749-6632.1999.tb07821.x
   Lodygin D, 2013, NAT MED, V19, P784, DOI 10.1038/nm.3182
   Lord GM, 1998, NATURE, V394, P897, DOI 10.1038/29795
   Makki Kassem, 2013, ISRN Inflamm, V2013, P139239, DOI 10.1155/2013/139239
   Maswood N, 2004, P NATL ACAD SCI USA, V101, P18171, DOI 10.1073/pnas.0405831102
   Matarese G, 2005, P NATL ACAD SCI USA, V102, P5150, DOI 10.1073/pnas.0408995102
   Mauro C, 2012, FRONT IMMUNOL, V3, DOI 10.3389/fimmu.2012.00173
   Mehta D, 2006, PHYSIOL REV, V86, P279, DOI 10.1152/physrev.00012.2005
   Miller DW, 1999, J NEUROVIROL, V5, P570, DOI 10.3109/13550289909021286
   Misiak B, 2012, BRAIN RES BULL, V89, P144, DOI 10.1016/j.brainresbull.2012.08.003
   Montiel-Castro AJ, 2013, FRONT INTEGR NEUROSC, V7, DOI 10.3389/fnint.2013.00070
   Neuwelt E, 2008, LANCET NEUROL, V7, P84, DOI 10.1016/S1474-4422(07)70326-5
   Neuwelt EA, 2011, NAT REV NEUROSCI, V12, P169, DOI 10.1038/nrn2995
   Nimmo Alan J, 2009, Recent Pat CNS Drug Discov, V4, P86
   Odoardi F, 2012, NATURE, V488, P675, DOI 10.1038/nature11337
   Ousman SS, 2012, NAT NEUROSCI, V15, P1096, DOI 10.1038/nn.3161
   Ouyang SD, 2014, J CEREBR BLOOD F MET, V34, P43, DOI 10.1038/jcbfm.2013.166
   Pardridge W M, 1991, Semin Cell Biol, V2, P419
   Parrott MD, 2007, ANN NY ACAD SCI, V1114, P389, DOI 10.1196/annals.1396.028
   Peter C, 2010, CURR OPIN IMMUNOL, V22, P655, DOI 10.1016/j.coi.2010.08.010
   Piccio L, 2008, J LEUKOCYTE BIOL, V84, P940, DOI 10.1189/jlb.0208133
   Powell JD, 2010, IMMUNITY, V33, P301, DOI 10.1016/j.immuni.2010.09.002
   Procaccini C, 2014, FRONT IMMUNOL, V5, DOI 10.3389/fimmu.2014.00143
   Ransohoff RM, 2012, NAT REV IMMUNOL, V12, P623, DOI 10.1038/nri3265
   Reboldi A, 2009, NAT IMMUNOL, V10, P514, DOI 10.1038/ni.1716
   Romero IA, 2003, NEUROSCI LETT, V344, P112, DOI 10.1016/S0304-3940(03)00348-3
   Schinkel AH, 1996, J CLIN INVEST, V97, P2517, DOI 10.1172/JCI118699
   Shefer G, 2013, NEUROSCI BIOBEHAV R, V37, P2489, DOI 10.1016/j.neubiorev.2013.07.015
   Wiernan HL, 2007, MOL BIOL CELL, V18, P1437, DOI 10.1091/mbc.E06-07-0593
   Wilson EH, 2010, J CLIN INVEST, V120, P1368, DOI 10.1172/JCI41911
   Wolf AM, 1998, OBES RES, V6, P97, DOI 10.1002/j.1550-8528.1998.tb00322.x
   Yaffe K, 2004, JAMA-J AM MED ASSOC, V292, P2237, DOI 10.1001/jama.292.18.2237
   Yarchoan M, 2014, DIABETES, V63, P2253, DOI 10.2337/db14-0287
   Yates KF, 2012, ARTERIOSCL THROM VAS, V32, P2060, DOI 10.1161/ATVBAHA.112.252759
NR 61
TC 30
Z9 30
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD JAN 5
PY 2015
VL 5
BP 1
EP 6
AR 677
DI 10.3389/fimmu.2014.00677
PG 6
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA CI2TC
UT WOS:000354598900001
PM 25601869
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kawai, H
   Kurata, T
   Deguchi, K
   Deguchi, S
   Yamashita, T
   Ohta, Y
   Omote, Y
   Kono, S
   Abe, K
AF Kawai, Hiromi
   Kurata, Tomoko
   Deguchi, Kentaro
   Deguchi, Shoko
   Yamashita, Toru
   Ohta, Yasuyuki
   Omote, Yoshio
   Kono, Syoichiro
   Abe, Koji
TI Combination benefit of amlodipine plus atorvastatin treatment on carotid
   atherosclerosis in Zucker metabolic rats
SO NEUROLOGICAL RESEARCH
LA English
DT Article
DE Amlodipine; Atorvastatin; Common carotid artery; Zucker fatty rat
ID MONOCYTE CHEMOATTRACTANT PROTEIN-1; SPONTANEOUSLY HYPERTENSIVE-RATS;
   SMOOTH-MUSCLE-CELLS; INSULIN-RESISTANCE; OXIDATIVE STRESS; DEFICIENT
   MICE; BLOOD-PRESSURE; UP-REGULATION; SIRT1; RECEPTOR
AB Objectives: Obesity is the major risk factor for metabolic syndrome and atherosclerotic cardiocerebrovascular diseases.
   Methods: We studied effects of amlodipine, atorvastatin, and their combination on carotid arteriosclerotic processes in a metabolic syndrome model of Zucker fatty rats. Zucker fatty rats were treated with vehicle, amlodipine, atorvastatin, or combination amlodipine plus atorvastatin for 28 days.
   Results: Compared with the single treatment with amlodipine or atorvastatin, the combination of amlodipine plus atorvastatin treatment prevented arteriosclerotic processes, and induced a strong recovery of Sirtuin1 (Sirt1) expression and a marked reduction in p53, p21, and monocyte chemoattractant protein-1 (MCP-1).
   Discussion: As Sirt1 is a longevity gene that prevents endothelial atherosclerotic processes, and p53, p21, and MCP-1 play pivotal roles in the initiation and development of atherosclerosis, these data suggest a strong synergistic benefit of combination therapy with amlodipine and atorvastatin for preventing atherosclerotic processes, and potentially reducing the clinical risk of cerebrovascular events in metabolic obesity patients.
C1 [Kawai, Hiromi; Kurata, Tomoko; Deguchi, Kentaro; Deguchi, Shoko; Yamashita, Toru; Ohta, Yasuyuki; Omote, Yoshio; Kono, Syoichiro; Abe, Koji] Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci, Okayama 7008558, Japan.
C3 Okayama University
RP Abe, K (corresponding author), Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci, 2-5-1 Shikatacho, Okayama 7008558, Japan.
EM toko11@cc.okayama-u.ac.jp
OI Yamashita, Toru/0000-0003-3634-5679
FU Ministry of Education, Science, Culture and Sports of Japan; Research
   Committee of CNS Degenerative Diseases; Ministry of Health, Labour and
   Welfare of Japan;  [21390267]
FX This study was supported in part by a Grant-in-Aid for Scientific
   Research (B) 21390267 and the Ministry of Education, Science, Culture
   and Sports of Japan, by Grants-in-Aid from the Research Committee of CNS
   Degenerative Diseases (Nakano I), and by grants (Mizusawa H, Nishizawa
   M, Sasaki H, Sobue G) from the Ministry of Health, Labour and Welfare of
   Japan.
CR Amarenco P, 2006, NEW ENGL J MED, V355, P549
   Andrews TJ, 2000, J PHARM PHARMACOL, V52, P83, DOI 10.1211/0022357001773544
   Annoura H, 1999, BIOORG MED CHEM LETT, V9, P2999, DOI 10.1016/S0960-894X(99)00516-8
   Boring L, 1998, NATURE, V394, P894, DOI 10.1038/29788
   Braunersreuther V, 2007, THROMB HAEMOSTASIS, V97, P714, DOI 10.1160/TH07-01-0036
   Chang BD, 2000, P NATL ACAD SCI USA, V97, P4291, DOI 10.1073/pnas.97.8.4291
   Contreras C, 2011, ATHEROSCLEROSIS, V217, P331, DOI 10.1016/j.atherosclerosis.2011.03.036
   Dandona Paresh, 2002, Diabetes Technol Ther, V4, P809, DOI 10.1089/152091502321118829
   Dorafshar AH, 2010, DIABETES VASC DIS RE, V7, P20, DOI 10.1177/1479164109341688
   Gao P, NEUROSURGERY, V67, P1029
   Ginsberg HN, 2000, J CLIN INVEST, V106, P453, DOI 10.1172/JCI10762
   Gosling J, 1999, J CLIN INVEST, V103, P773, DOI 10.1172/JCI5624
   Gu L, 1998, MOL CELL, V2, P275, DOI 10.1016/S1097-2765(00)80139-2
   Hamakawa Y, 2004, NEUROL RES, V26, P767, DOI 10.1179/016164104225016074
   Hayashi T, 2005, BRAIN RES, V1037, P52, DOI 10.1016/j.brainres.2004.12.051
   Hsueh WA, 2003, AM J CARDIOL, V92, p10J, DOI 10.1016/S0002-9149(03)00611-8
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Kawai H, 2011, BRAIN RES, V1382, P308, DOI 10.1016/j.brainres.2011.01.062
   Kawai H, 2011, BRAIN RES, V1368, P317, DOI 10.1016/j.brainres.2010.10.046
   King VL, 2010, OBESITY, V18, P35, DOI 10.1038/oby.2009.176
   KRAMSCH DM, 1995, J HUM HYPERTENS, V9, pS3
   Kunieda T, 2006, CIRCULATION, V114, P953, DOI 10.1161/CIRCULATIONAHA.106.626606
   Lai YM, 2002, HYPERTENS RES, V25, P109, DOI 10.1291/hypres.25.109
   Laight DW, 1998, BRIT J PHARMACOL, V125, P895, DOI 10.1038/sj.bjp.0702132
   Libby P, 2000, J INTERN MED, V247, P349, DOI 10.1046/j.1365-2796.2000.00654.x
   Loke KE, 2000, J MOL CELL CARDIOL, V32, P2299, DOI 10.1006/jmcc.2000.1258
   Lukic-Panin V, 2007, BRAIN RES, V1176, P143, DOI 10.1016/j.brainres.2007.07.038
   Mattagajasingh I, 2007, P NATL ACAD SCI USA, V104, P14855, DOI 10.1073/pnas.0704329104
   Mercer J, 2006, CELL CYCLE, V5, P1907, DOI 10.4161/cc.5.17.3166
   Merched AJ, 2004, CIRCULATION, V110, P3830, DOI 10.1161/01.CIR.0000148681.01282.89
   Miyazaki R, 2008, ARTERIOSCL THROM VAS, V28, P1263, DOI 10.1161/ATVBAHA.108.166991
   Moral-Sanz J, 2011, RESP RES, V12, DOI 10.1186/1465-9921-12-51
   Murthy SN, 2010, DIABETES, V59, P3240, DOI 10.2337/db09-1761
   Nagotani S, 2005, STROKE, V36, P670, DOI 10.1161/01.STR.0000155732.27333.3c
   Namiki M, 2002, ARTERIOSCL THROM VAS, V22, P115, DOI 10.1161/hq0102.102278
   Osmond JM, 2010, AM J PHYSIOL-HEART C, V299, pH55, DOI 10.1152/ajpheart.01111.2009
   Ota H, 2007, J MOL CELL CARDIOL, V43, P571, DOI 10.1016/j.yjmcc.2007.08.008
   Rami A, 2008, NEUROBIOL DIS, V29, P132, DOI 10.1016/j.nbd.2007.08.005
   Schecter AD, 1997, J BIOL CHEM, V272, P28568, DOI 10.1074/jbc.272.45.28568
   Shimano Hitoshi, 2009, Nihon Rinsho, V67, P333
   Subramanian R, 2003, EUR J PHARMACOL, V477, P143, DOI 10.1016/j.ejphar.2003.08.003
   Thaulow E, 2000, CAN J CARDIOL, V16, p8D
   Tsuchiya A, 2007, CURR NEUROVASC RES, V4, P268, DOI 10.2174/156720207782446333
   Vaziri ND, 2005, KIDNEY INT, V68, P2787, DOI 10.1111/j.1523-1755.2005.00750.x
   Zhang QJ, 2008, CARDIOVASC RES, V80, P191, DOI 10.1093/cvr/cvn224
   ZUCKER LM, 1972, ENDOCRINOLOGY, V90, P1320, DOI 10.1210/endo-90-5-1320
   ZUCKER LM, 1965, ANN NY ACAD SCI, V131, P447, DOI 10.1111/j.1749-6632.1965.tb34810.x
NR 47
TC 5
Z9 5
U1 0
U2 7
PU MANEY PUBLISHING
PI LEEDS
PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND
SN 0161-6412
J9 NEUROL RES
JI Neurol. Res.
PD MAR
PY 2013
VL 35
IS 2
BP 181
EP 186
DI 10.1179/1743132812Y.0000000131
PG 6
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 101KL
UT WOS:000315773800015
PM 23336931
DA 2025-06-11
ER

PT J
AU Hernández-Pérez, S
   Oliart-Ros, RM
   Casas-Godoy, L
   Sandoval, G
   Guarner-Lans, V
   Castrejón-Téllez, V
   Quevedo-Corona, L
   Peña-Montes, C
   Ramirez-Higuera, A
AF Hernandez-Perez, Susana
   Oliart-Ros, Rosa Maria
   Casas-Godoy, Leticia
   Sandoval, Georgina
   Guarner-Lans, Veronica
   Castrejon-Tellez, Vicente
   Quevedo-Corona, Lucia
   Pena-Montes, Carolina
   Ramirez-Higuera, Abril
TI Beneficial Effects of Fructooligosaccharides Esterified with Lauric Acid
   in a Metabolic Syndrome Model Induced by a High-Fat and
   High-Carbohydrate Diet in Wistar Rats
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Article
DE Agave; fructooligosaccharides; high-fat high-carbohydrate diet; lauric
   acid; prebiotics
ID AGAVE-TEQUILANA FRUCTANS; SUCROSE; OBESITY; WEIGHT
AB Metabolic syndrome (MS) is a group of abnormalities in which obesity, insulin resistance (IR), oxidative stress, and dyslipidemia stand out. This pathology predisposes to the development of cardiovascular diseases and diabetes. The ingestion of linear fructooligosaccharides (FOS) such as inulin reduces conditions such as hyperinsulinemia, increased body fat, and triglyceridemia. When FOS are esterified with fatty acids, they present emulsifying and surfactant properties; however, there are no reports of their function at the biological level. The purpose of this investigation was to evaluate the effect of Agave tequilana Weber's FOS (AtW-FOS) and FOS esterified with lauric acid (FOS-LA) in MS markers in a rat model induced by a HFHC diet. Supplementation with AtW-FOS and FOS-LA decreased IR, improved glucose tolerance, reduced liver weight (19%), plasma triglycerides (24%), and blood pressure (16%) when compared with the untreated MS group. In conclusion, the ingestion of AtW-FOS and FOS-LA has beneficial effects in the prevention of MS alterations, showing a high potential for their application in functional foods.
C1 [Hernandez-Perez, Susana; Oliart-Ros, Rosa Maria; Pena-Montes, Carolina; Ramirez-Higuera, Abril] Natl Tech Mexico Tecnol Nacl Mexico IT Veracruz, Res & Food Dev Unit UNIDA, Veracruz, Mexico.
   [Casas-Godoy, Leticia] CONACYT Ctr Res & Asistance Technol & Design Jali, Ind Biotechnol Unit, Zapopan, Jalisco, Mexico.
   [Sandoval, Georgina] Ctr Res & Asistance Technol & Design Jalisco Stat, Ind Biotechnol Unit, Guadalajara, Jalisco, Mexico.
   [Guarner-Lans, Veronica; Castrejon-Tellez, Vicente] Natl Inst Cardiol Ignacio Chavez, Dept Physiol, Mexico City, Mexico.
   [Quevedo-Corona, Lucia] Natl Polytech Inst IPN, Natl Sch Biol Sci ENCB, Dept Physiol, Mexico City, Mexico.
C3 National Institute of Cardiology - Mexico; Instituto Politecnico
   Nacional - Mexico
RP Ramirez-Higuera, A (corresponding author), Nacl Mexico IT Veracruz, Miguel Angel Quevedo 2779, Veracruz, Mexico.
EM abrilhiguera@hotmail.com
RI Sandoval, Georgina/ABB-8999-2020; V, Guarner/AFW-2513-2022; Peña-Montes,
   Carolina/AAD-1192-2021; Oliart-Ros, Rosamaria/AAS-5105-2021;
   Casas-Godoy, Leticia/G-2818-2019; Sandoval, Georgina/C-3327-2008
OI Casas-Godoy, Leticia/0000-0002-0566-5824; Sandoval,
   Georgina/0000-0002-9105-0702; Ramirez Higuera,
   Abril/0000-0002-1430-2689; Pena-Montes, Carolina/0000-0002-4767-1210
FU Consejo Nacional de Ciencia y Tecnologia
FX The financial support provided by Consejo Nacional de Ciencia y
   Tecnologia for Susana Hernandez-Perez master fellowship.
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   Aguilar-Salinas Carlos A, 2019, F1000Res, V8, DOI 10.12688/f1000research.17122.1
   Casas-Godoy L, 2016, FOOD CHEM, V204, P437, DOI 10.1016/j.foodchem.2016.02.153
   Delgado GTC, 2018, FOOD RES INT, V113, P183, DOI 10.1016/j.foodres.2018.07.013
   Costa GT, 2015, ACTA CIR BRAS, V30, P366, DOI 10.1590/S0102-865020150050000009
   Dayrit FM, 2015, J AM OIL CHEM SOC, V92, P1, DOI 10.1007/s11746-014-2562-7
   Go AS, 2013, CIRCULATION, V127, P143, DOI [10.1161/CIR.0b013e318282ab8f, 10.1161/CIR.0000000000000366]
   Hamidi R., 2014, Maced. Pharm. Bull, V60, P9, DOI DOI 10.33320/MACED.PHARM.BULL.2014.60.01.002
   Hasan Entezari M., 2017, J. Prev. Epidemiol, V2, pe02
   He MQ, 2017, CELL BIOSCI, V7, DOI 10.1186/s13578-017-0183-1
   Ibinga SKK, 2019, FRONT CHEM, V7, DOI 10.3389/fchem.2019.00587
   John GK, 2018, GENES-BASEL, V9, DOI 10.3390/genes9030167
   Kerry RG, 2018, J FOOD DRUG ANAL, V26, P927, DOI 10.1016/j.jfda.2018.01.002
   Laguna CA., 2004, THESIS AUTONOMOUS ME
   Lamas R., 2004, CIENCIA TECNOLOGIA T
   Márquez-Aguirre AL, 2013, FOOD FUNCT, V4, P1237, DOI 10.1039/c3fo60083a
   Le Lay S, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/908539
   Llisterri CJL., 2006, SEMERGEN MED FAM, V32, P73
   Markowiak-Kopec P, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041107
   Márquez-Aguirre AL, 2016, PLANT FOOD HUM NUTR, V71, P416, DOI 10.1007/s11130-016-0578-x
   Merino-Aguilar H, 2014, NUTRIENTS, V6, P591, DOI 10.3390/nu6020591
   Nery CD, 2011, REV BRAS MED ESPORTE, V17, P49, DOI 10.1590/S1517-86922011000100010
   Novelli ELB, 2007, LAB ANIM-UK, V41, P111, DOI 10.1258/002367707779399518
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Queneau Y, 2008, CARBOHYD RES, V343, P1999, DOI 10.1016/j.carres.2008.02.008
   Ramírez-Higuera A, 2020, J MED FOOD, V23, P305, DOI 10.1089/jmf.2019.0177
   Tremblay A, 2013, INT J OBESITY, V37, P759, DOI 10.1038/ijo.2012.124
   Ulloa Al, 2010, Revista Fuente, V2, P57
   Villegas-Romero M, 2018, NUTRIENTS, V10, DOI 10.3390/nu10060728
NR 29
TC 9
Z9 9
U1 2
U2 11
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD AUG 1
PY 2022
VL 25
IS 8
BP 828
EP 835
DI 10.1089/jmf.2021.0109
EA APR 2022
PG 8
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA 3V3KA
UT WOS:000782512600001
PM 35394894
DA 2025-06-11
ER

PT J
AU Rupp, H
   Maisch, B
AF Rupp, H
   Maisch, B
TI Abdominal fat and sympathetic overactivity
SO HERZ
LA English
DT Article
DE hypertension; sympathoadrenergic stimulation; central obesity
ID ANGIOTENSIN-II FORMATION; VISCERAL ADIPOSE-TISSUE; INSULIN-RESISTANCE;
   SYSTOLIC HYPERTENSION; METABOLIC SYNDROME; BODY-COMPOSITION; NERVE
   ACTIVITY; ACTIVATION; STRESS; RISK
AB Background: Epidemiologic studies have found an association between overweight and increased mortality arising primarily from cardiovascular disorders. A major determinant is a chronically raised sympathetic nervous system activity which can arise from calorie intake-dependent and -independent mechanisms. Calorie-dependent parameters reflecting sympathetic overactivity are an increased body fat mass and body mass index.
   Visceral Fat: Although influenced by calorie intake to a certain extent, visceral fat accumulation is a mechanism which is determined also by estrogen deficiency (postmenopausal hypertension) or enhanced corticoid influences. It is hypothesized that excess catecholamines trigger various adverse processes which, if they persist, can lead or aggravate hypertension and insulin resistance. Visceral but not peripheral fat mass was correlated with atherogenic metabolites.
   Excess Catecholamine Syndrome: The present focus on visceral fat accumulation strengthens the concept of an "excess catecholamine syndrome" of which the "metabolic syndrome" appears as one consequence. It is proposed to further assess the potential of transthoracic echocardiography as routine imaging method for the prediction of visceral fat accumulation and its adverse health consequences.
C1 Univ Marburg, Mol Cardiol Lab, Dept Internal Med & Cardiol, D-35033 Marburg, Germany.
C3 Philipps University Marburg
RP Univ Marburg, Mol Cardiol Lab, Dept Internal Med & Cardiol, Karl Von Frisch Str 1, D-35033 Marburg, Germany.
EM Rupp@staff.uni-marburg.de
RI Maisch, Bernhard/AAH-9198-2020
CR Alvarez GE, 2002, CIRCULATION, V106, P2533, DOI 10.1161/01.CIR.0000041244.79165.25
   Arakawa K, 2000, HYPERTENSION, V36, P638, DOI 10.1161/01.HYP.36.4.638
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   Bosma H, 1998, AM J PUBLIC HEALTH, V88, P68, DOI 10.2105/AJPH.88.1.68
   Brilla CG, 1997, J HYPERTENS, V15, pS13, DOI 10.1097/00004872-199715066-00004
   Eikelis N, 2003, HYPERTENSION, V41, P1072, DOI 10.1161/01.HYP.0000066289.17754.49
   Esler M, 2001, AM J HYPERTENS, V14, p304S, DOI 10.1016/S0895-7061(01)02236-1
   Esler M, 2003, ACTA PHYSIOL SCAND, V177, P275, DOI 10.1046/j.1365-201X.2003.01089.x
   Esler M, 2002, J HYPERTENS, V20, pS13
   Frayn KN, 2000, BRIT J NUTR, V83, pS71, DOI 10.1017/S0007114500000982
   GRASSI G, 1995, HYPERTENSION, V25, P560, DOI 10.1161/01.HYP.25.4.560
   Grassi G, 1998, CIRCULATION, V97, P2037, DOI 10.1161/01.CIR.97.20.2037
   Grassi G, 2001, HYPERTENSION, V38, P1316, DOI 10.1161/hy1201.096117
   Iacobellis G, 2003, OBES RES, V11, P304, DOI 10.1038/oby.2003.45
   Ihara M, 1999, HYPERTENSION, V33, P1399, DOI 10.1161/01.HYP.33.6.1399
   Izzo JL, 2000, BLOOD PRESS MONIT, V5, pS7, DOI 10.1097/00126097-200010002-00003
   JONES PP, 1996, AM J PHYSIOL, V270, pE636
   JULIUS S, 1971, CIRCULATION, V43, P382, DOI 10.1161/01.CIR.43.3.382
   LEY CJ, 1992, AM J CLIN NUTR, V55, P950, DOI 10.1093/ajcn/55.5.950
   LIND L, 1993, AM HEART J, V125, P1494, DOI 10.1016/0002-8703(93)90446-G
   Lissner L, 2001, OBES RES, V9, P644, DOI 10.1038/oby.2001.85
   Muller M J, 2002, Obes Rev, V3, P113, DOI 10.1046/j.1467-789X.2002.00057.x
   PASQUALI R, 1994, INT J OBESITY, V18, P614
   Peter R, 1997, SOC SCI MED, V45, P1111, DOI 10.1016/S0277-9536(97)00039-7
   POEHLMAN ET, 1995, ANN INTERN MED, V123, P673, DOI 10.7326/0003-4819-123-9-199511010-00005
   Randle PJ, 1998, DIABETES METAB REV, V14, P263, DOI 10.1002/(SICI)1099-0895(199812)14:4<263::AID-DMR233>3.0.CO;2-C
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Rupp H, 1999, AM J PHYSIOL-HEART C, V277, pH1540, DOI 10.1152/ajpheart.1999.277.4.H1540
   Rupp H, 1997, AM J PHYSIOL-REG I, V272, pR776, DOI 10.1152/ajpregu.1997.272.3.R776
   Rupp H, 1999, ANN NY ACAD SCI, V881, P430, DOI 10.1111/j.1749-6632.1999.tb09391.x
   RUPP H, 1995, MED HYPOTHESES, V44, P217, DOI 10.1016/0306-9877(95)90139-6
   Rupp H., 2001, THE J, V4, P47
   SCHERRER U, 1994, CIRCULATION, V89, P2634, DOI 10.1161/01.CIR.89.6.2634
   SCHOLKENS BA, 1980, CLIN SCI, V59, pS53, DOI 10.1042/cs059053s
   Seidell JC, 2001, AM J CLIN NUTR, V74, P315
   Siegrist J, 1997, ACTA PHYSIOL SCAND, V161, P112
   Snijder MB, 2003, AM J CLIN NUTR, V77, P1192, DOI 10.1093/ajcn/77.5.1192
   Staessen JA, 2000, LANCET, V355, P865, DOI 10.1016/S0140-6736(99)07330-4
   Sumino H, 2003, INT J OBESITY, V27, P1044, DOI 10.1038/sj.ijo.0802371
   Taguchi R, 2001, ATHEROSCLEROSIS, V157, P203, DOI 10.1016/S0021-9150(00)00709-7
   Tankó LB, 2003, CIRCULATION, V107, P1626, DOI 10.1161/01.CIR.0000057974.74060.68
   Toth MJ, 2000, INT J OBESITY, V24, P226, DOI 10.1038/sj.ijo.0801118
   Vaz M, 1997, CIRCULATION, V96, P3423
   Wajchenberg BL, 2000, ENDOCR REV, V21, P697, DOI 10.1210/er.21.6.697
   Weitz G, 2001, J CLIN ENDOCR METAB, V86, P344, DOI 10.1210/jc.86.1.344
NR 45
TC 8
Z9 10
U1 0
U2 3
PU URBAN & VOGEL
PI MUNICH
PA NEUMARKTER STRASSE 43, D-81673 MUNICH, GERMANY
SN 0340-9937
EI 1615-6692
J9 HERZ
JI Herz
PD DEC
PY 2003
VL 28
IS 8
BP 668
EP 673
DI 10.1007/s00059-003-2517-5
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 761TZ
UT WOS:000187932700004
PM 14689100
DA 2025-06-11
ER

PT J
AU Vigod, SN
   Ray, JG
   Cohen, E
   Wilton, AS
   Saunders, NR
   Barker, LC
   Berard, A
   Dennis, CL
   Holloway, AC
   Morrison, K
   Oberlander, TF
   Hanley, G
   Tu, K
   Brown, HK
AF Vigod, Simone N.
   Ray, Joel G.
   Cohen, Eyal
   Wilton, Andrew S.
   Saunders, Natasha R.
   Barker, Lucy C.
   Berard, Anick
   Dennis, Cindy-Lee
   Holloway, Alison C.
   Morrison, Katherine
   Oberlander, Tim F.
   Hanley, Gillian
   Tu, Karen
   Brown, Hilary K.
TI Maternal Schizophrenia and the Risk of a Childhood Chronic Condition
SO SCHIZOPHRENIA BULLETIN
LA English
DT Article
DE Schizophrenia; Pregnancy; Child Health
ID SERIOUS MENTAL-ILLNESS; DEVELOPMENTAL ORIGINS; METABOLIC SYNDROME;
   DIABETES-MELLITUS; SEX-DIFFERENCES; WOMEN; HEALTH; CARE; DISORDERS;
   MOTHERS
AB Background and Hypothesis Maternal schizophrenia heightens the risk for certain perinatal complications, yet it is not known to what degree future childhood chronic health conditions (Childhood-CC) might arise. Study Design This population-based cohort study using health administrative data from Ontario, Canada (1995-2018) compared 5066 children of mothers with schizophrenia to 25 324 children of mothers without schizophrenia, propensity-matched on birth-year, maternal age, parity, immigrant status, income, region of residence, and maternal medical and psychiatric conditions other than schizophrenia. Cox proportional hazard models generated hazard ratios (HR) and 95% confidence intervals (CI) for incident Childhood-CCs, and all-cause mortality, up to age 19 years. Study Results Six hundred and fifty-six children exposed to maternal schizophrenia developed a Childhood-CC (20.5/1000 person-years) vs. 2872 unexposed children (17.1/1000 person-years)-an HR of 1.18, 95% CI 1.08-1.28. Corresponding rates were 3.3 vs. 1.9/1000 person-years (1.77, 1.44-2.18) for mental health Childhood-CC, and 18.0 vs. 15.7/1000 person-years (1.13, 1.04-1.24) for non-mental health Childhood-CC. All-cause mortality rates were 1.2 vs. 0.8/1000 person-years (1.34, 0.96-1.89). Risk for children exposed to maternal schizophrenia was similar whether or not children were discharged to social service care. From age 1 year, risk was greater for children whose mothers were diagnosed with schizophrenia prior to pregnancy than for children whose mothers were diagnosed with schizophrenia postnatally. Conclusions A child exposed to maternal schizophrenia is at elevated risk of chronic health conditions including mental and physical subtypes. Future research should examine what explains the increased risk particularly for physical health conditions, and what preventive and treatment efforts are needed for these children.
C1 [Vigod, Simone N.; Barker, Lucy C.; Dennis, Cindy-Lee; Brown, Hilary K.] Womens Coll Hosp, Toronto, ON, Canada.
   [Vigod, Simone N.; Barker, Lucy C.; Dennis, Cindy-Lee; Brown, Hilary K.] Womens Coll, Res Inst, Toronto, ON, Canada.
   [Vigod, Simone N.; Barker, Lucy C.; Dennis, Cindy-Lee; Brown, Hilary K.] Univ Toronto, Temerty Fac Med, Dept Psychiat, Toronto, ON, Canada.
   [Vigod, Simone N.; Ray, Joel G.; Cohen, Eyal; Saunders, Natasha R.; Barker, Lucy C.; Tu, Karen; Brown, Hilary K.] Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada.
   [Vigod, Simone N.; Ray, Joel G.; Cohen, Eyal; Wilton, Andrew S.; Saunders, Natasha R.; Barker, Lucy C.; Brown, Hilary K.] ICES, Toronto, ON, Canada.
   [Ray, Joel G.] St Michaels Hosp, Toronto, ON, Canada.
   [Ray, Joel G.] Univ Toronto, Temerty Fac Med, Dept Med, Toronto, ON, Canada.
   [Cohen, Eyal; Saunders, Natasha R.] Hosp Sick Children, Edwin SH Leong Ctr Hlth Children, Toronto, ON, Canada.
   [Cohen, Eyal; Saunders, Natasha R.] Univ Toronto, Temerty Fac Med, Dept Pediat, Toronto, ON, Canada.
   [Berard, Anick] Univ Montreal, Fac Pharm, Montreal, PQ, Canada.
   [Berard, Anick] CHU Ste Justine, Montreal, PQ, Canada.
   [Dennis, Cindy-Lee] Univ Toronto, Lawrence S BloombergFac Nursing, Toronto, ON, Canada.
   [Holloway, Alison C.] McMaster Univ, Dept Obstet & Gynecol, Hamilton, ON, Canada.
   [Morrison, Katherine] McMaster Univ, Dept Pediat, Hamilton, ON, Canada.
   [Oberlander, Tim F.] Univ British Columbia, Dept Pediat, Vancouver, BC, Canada.
   [Hanley, Gillian] Univ British Columbia, Dept Obstet & Gynecol, Vancouver, BC, Canada.
   [Tu, Karen] Univ Toronto, Dept Family & Community Med, Temerty Fac Med, North York Gen Hosp,Toronto Western Hosp,Family H, Toronto, ON, Canada.
   [Brown, Hilary K.] Univ Toronto, Dept Hlth & Soc, Toronto, ON, Canada.
C3 University of Toronto; Womens College Hospital; University of Toronto;
   Women's College Research Institute; University of Toronto; University of
   Toronto; University of Toronto; Saint Michaels Hospital Toronto;
   University of Toronto; University of Toronto; Hospital for Sick Children
   (SickKids); University of Toronto; Universite de Montreal; Universite de
   Montreal; University of Toronto; McMaster University; McMaster
   University; University of British Columbia; University of British
   Columbia; University of Toronto; North York General Hospital; University
   Health Network Toronto; University of Toronto
RP Vigod, SN (corresponding author), Womens Coll Hosp, Dept Psychiat, 76 Grenville St, Toronto, ON, Canada.
EM simone.vigod@wchospital.ca
RI Cohen, Eyal/K-2575-2014; Tu, Karen/MDT-1460-2025; Morrison,
   Katherine/AAO-8046-2021; Dennis, Cindy-Lee/ABA-2860-2020
OI Dennis, Cindy-Lee/0000-0002-0135-7242; Vigod,
   Simone/0000-0002-2736-9639; Hanley, Gillian/0000-0001-9594-0545;
   Oberlander, Tim/0000-0003-4781-6579; Holloway,
   Alison/0000-0002-4343-5325
FU Canadian Institutes for Health Research [PJT156021]
FX This study was funded by an operating grant from the Canadian Institutes
   for Health Research (PJT156021). The funder/sponsor did not participate
   in the work.
CR [Anonymous], 2005, Canadian Journal of Psychiatry, V50, p1S
   Arvidsson H, 2010, INT J SOC PSYCHIATR, V56, P424, DOI 10.1177/0020764009106631
   Austin PC, 2009, STAT MED, V28, P3083, DOI 10.1002/sim.3697
   Balsells M, 2012, DIABETES-METAB RES, V28, P252, DOI 10.1002/dmrr.1304
   Berry Jay G, 2017, Hosp Pediatr, V7, P365, DOI 10.1542/hpeds.2016-0179
   Blighe K, 2017, AM J CLIN NUTR, V106, P1092, DOI 10.3945/ajcn.117.158220
   Boney CM, 2005, PEDIATRICS, V115, pE290, DOI 10.1542/peds.2004-1808
   Czeizel AE, 2013, NUTRIENTS, V5, P4760, DOI 10.3390/nu5114760
   Davidsen KA, 2022, ACTA PSYCHIAT SCAND, V145, P244, DOI 10.1111/acps.13358
   Friedman B, 2006, MED CARE RES REV, V63, P327, DOI 10.1177/1077558706287042
   Grossman LS, 2008, COMPR PSYCHIAT, V49, P523, DOI 10.1016/j.comppsych.2008.03.004
   Grossman LS, 2006, PSYCHIAT SERV, V57, P844, DOI 10.1176/appi.ps.57.6.844
   Gudmundsson OO, 2019, TRANSL PSYCHIAT, V9, DOI 10.1038/s41398-019-0599-y
   Hameed MA, 2016, HARVARD REV PSYCHIAT, V24, P104, DOI 10.1097/HRP.0000000000000076
   Heindel JJ, 2015, CURR OPIN PEDIATR, V27, P248, DOI 10.1097/MOP.0000000000000191
   Henriksson KM, 2004, SCHIZOPHR RES, V70, P39, DOI 10.1016/j.schres.2003.11.003
   Hux JE, 2002, DIABETES CARE, V25, P512, DOI 10.2337/diacare.25.3.512
   Hwang W, 2001, HEALTH AFFAIR, V20, P267, DOI 10.1377/hlthaff.20.6.267
   Kurdyak P, 2017, GEN HOSP PSYCHIAT, V46, P7, DOI 10.1016/j.genhosppsych.2017.02.001
   Kurdyak P, 2015, CAN J PSYCHIAT, V60, P362, DOI 10.1177/070674371506000805
   Lacey M, 2015, PSYCHIAT RES, V225, P723, DOI 10.1016/j.psychres.2014.09.010
   Li S, 2014, OBES REV, V15, P804, DOI 10.1111/obr.12214
   Medsker B, 2015, OBSTET GYNECOL SURV, V70, P773, DOI 10.1097/OGX.0000000000000256
   Nevriana A, 2022, J PSYCHIATR RES, V151, P122, DOI 10.1016/j.jpsychires.2022.04.017
   Newcomer JW, 2007, AM J MANAG CARE, V13, pS170
   Niemi LT, 2004, BRIT J PSYCHIAT, V185, P11, DOI 10.1192/bjp.185.1.11
   Parkerson GR, 2001, MED CARE, V39, P1170, DOI 10.1097/00005650-200111000-00004
   Quan HD, 2009, HYPERTENSION, V54, P1423, DOI 10.1161/HYPERTENSIONAHA.109.139279
   Ranning A, 2020, SCHIZOPHRENIA BULL, V46, P130, DOI 10.1093/schbul/sbz040
   Ranning A, 2015, J CLIN PSYCHIAT, V76, pE1006, DOI 10.4088/JCP.13m08931
   Ray JG, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000337
   Saha S, 2005, PLOS MED, V2, P413, DOI 10.1371/journal.pmed.0020141
   Schubert EW, 2003, ARCH GEN PSYCHIAT, V60, P473, DOI 10.1001/archpsyc.60.5.473
   Seeman MV, 2013, ACTA PSYCHIAT SCAND, V127, P12, DOI 10.1111/j.1600-0447.2012.01897.x
   Sheffield JS, 2002, OBSTET GYNECOL, V100, P925, DOI 10.1016/S0029-7844(02)02242-1
   Smith CJ, 2015, DIABETES METAB SYNDR, V8, P295, DOI 10.2147/DMSO.S61296
   Smoller JW, 2013, LANCET, V381, P1371, DOI 10.1016/S0140-6736(12)62129-1
   Vigod SN, 2014, BJOG-INT J OBSTET GY, V121, P566, DOI 10.1111/1471-0528.12567
   Vigod SN, 2012, SCHIZOPHR RES, V139, P169, DOI 10.1016/j.schres.2012.05.010
   Vigod SN, 2009, CURR OPIN PSYCHIATR, V22, P396, DOI 10.1097/YCO.0b013e3283297127
   Wadhwa PD, 2009, SEMIN REPROD MED, V27, P358, DOI 10.1055/s-0029-1237424
   Wan MW, 2008, GEN HOSP PSYCHIAT, V30, P177, DOI 10.1016/j.genhosppsych.2007.12.001
   Williams J., 1996, Patterns of health care in Ontario: the ICES practice atlas, V339, P45
NR 43
TC 3
Z9 3
U1 1
U2 11
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0586-7614
EI 1745-1701
J9 SCHIZOPHRENIA BULL
JI Schizophr. Bull.
PD NOV 18
PY 2022
VL 48
IS 6
BP 1252
EP 1262
DI 10.1093/schbul/sbac091
EA JUL 2022
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 6J1VL
UT WOS:000834316900001
PM 35900007
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Manso, MA
   Miguel, M
   Even, J
   Hernández, R
   Aleixandre, A
   López-Fandiño, R
AF Manso, Marfa A.
   Miguel, Marta
   Even, Jeanne
   Hernandez, Rosario
   Aleixandre, Amaya
   Lopez-Fandino, Rosina
TI Effect of the long-term intake of an egg white hydrolysate on the
   oxidative status and blood lipid profile of spontaneously hypertensive
   rats
SO FOOD CHEMISTRY
LA English
DT Article
DE antioxidant status; lipid profile; bioactive peptides; egg white;
   spontaneously hypertensive rats
ID RADICAL-SCAVENGING ACTIVITIES; CONVERTING ENZYME-INHIBITORS; ANTIOXIDANT
   ACTIVITY; METABOLIC SYNDROME; NITRIC-OXIDE; SOY PROTEIN; PEPTIDES;
   CAPTOPRIL; PRESSURE; RENIN
AB This paper examines the effects of the long-term consumption of egg white hydrolysed with pepsin (hEW) on the antioxidant status and lipid profile of spontaneously hypertensive rats (SHR). The antioxidant capacity was measured by the oxygen radical absorbance capacity (ORAC) and the oxidative status by the malon-dialdehyde (MDA) assay. The lipid profile was analysed spectrophotometrically. The radical-scavenging capacity of the plasma was increased and the MDA concentration in the aorta was decreased in the SHR treated with 0.5 g/kg/day of hEW. Our findings indicate that hEW played an important role in antioxidative defence of SHR and exerted a beneficial effect on the lipid profile, lowering triglycerides and total cholesterol without changing HDL levels. Therefore, hEW may be useful to prevent or reverse abnormalities associated with the metabolic syndrome and its complications, such as hypertension, oxidative stress and hyperlipidemia. (C) 2007 Elsevier Ltd. All rights reserved.
C1 [Manso, Marfa A.; Miguel, Marta; Even, Jeanne; Lopez-Fandino, Rosina] CSIC, Inst Fermentac Ind, E-28006 Madrid, Spain.
   [Miguel, Marta; Aleixandre, Amaya] Univ Complutense, Inst Farmacol & Toxicol, CSIC, Fac Med, E-28040 Madrid, Spain.
   [Hernandez, Rosario] Hosp Cent Def, CDEAS, Madrid 28007, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Fermentaciones Industriales (IFI); Complutense University of Madrid;
   Consejo Superior de Investigaciones Cientificas (CSIC)
RP López-Fandiño, R (corresponding author), CSIC, Inst Fermentac Ind, Juan Cierva 3, E-28006 Madrid, Spain.
EM rosina@ifi.csic.es
RI Manso, Maria/HTR-6904-2023; MIGUEL CASTRO, MARTA/F-6112-2011;
   Lopez-Fandino, Rosina/H-4132-2012
OI MIGUEL CASTRO, MARTA/0000-0002-5525-1056; Lopez-Fandino,
   Rosina/0000-0002-6979-9258; Manso Silvan, Maria
   Asuncion/0000-0002-5056-9065
CR Akpaffiong MJ, 1998, AM J HYPERTENS, V11, P1450, DOI 10.1016/S0895-7061(98)00183-6
   AMES BN, 1993, P NATL ACAD SCI USA, V90, P7915, DOI 10.1073/pnas.90.17.7915
   BAGCHI D, 1989, BIOCHEM BIOPH RES CO, V158, P52, DOI 10.1016/S0006-291X(89)80175-5
   BAIN SC, 1991, J HUM HYPERTENS, V5, P511
   Bolterman RJ, 2005, HYPERTENSION, V46, P943, DOI 10.1161/01.HYP.0000174602.59935.d5
   Dávalos A, 2004, J FOOD PROTECT, V67, P1939, DOI 10.4315/0362-028X-67.9.1939
   Dávalos A, 2004, J AGR FOOD CHEM, V52, P48, DOI 10.1021/jf0305231
   De Cavanagh EMV, 2000, AM J PHYSIOL-REG I, V278, pR572, DOI 10.1152/ajpregu.2000.278.3.R572
   Erdmann K, 2006, J NUTR, V136, P2148, DOI 10.1093/jn/136.8.2148
   ERNSBERGER P, 2006, N-S ARCH PHARMACOL, V273, P245
   Ernsberger P, 2007, AM J HYPERTENS, V20, P866, DOI 10.1016/j.amjhyper.2007.02.015
   Finkel T, 2000, NATURE, V408, P239, DOI 10.1038/35041687
   Fratta Pasini A, 2007, AM J HYPERTENS, V20, P443, DOI 10.1016/j.amjhyper.2006.09.020
   Griendling KK, 2000, REGUL PEPTIDES, V91, P21, DOI 10.1016/S0167-0115(00)00136-1
   Hernández-Ledesma B, 2005, J AGR FOOD CHEM, V53, P588, DOI 10.1021/jf048626m
   Kawase M, 2000, J DAIRY SCI, V83, P255, DOI 10.3168/jds.S0022-0302(00)74872-7
   Kedziora-Kornatowska KZ, 2000, IUBMB LIFE, V49, P303
   Kim SK, 2001, J AGR FOOD CHEM, V49, P1984, DOI 10.1021/jf000494j
   Kim SY, 2007, J NUTR BIOCHEM, V18, P31, DOI 10.1016/j.jnutbio.2006.02.006
   Kojsová S, 2006, PHYSIOL RES, V55, pS3, DOI 10.33549/physiolres.930000.55.S1.3
   Liu YH, 2007, J CARDIOVASC PHARM, V50, P155, DOI 10.1097/FJC.0b013e31805c9410
   Mervaala EMA, 2001, HYPERTENSION, V37, P414, DOI 10.1161/01.HYP.37.2.414
   Miguel M, 2005, BRIT J NUTR, V94, P731, DOI 10.1079/BJN20051570
   Miguel M, 2004, J FOOD PROTECT, V67, P1914, DOI 10.4315/0362-028X-67.9.1914
   Miguel M, 2007, J AGR FOOD CHEM, V55, P10615, DOI 10.1021/jf072307o
   Miguel M, 2007, MOL NUTR FOOD RES, V51, P555, DOI 10.1002/mnfr.200700012
   Miguel M, 2007, REGUL PEPTIDES, V140, P131, DOI 10.1016/j.regpep.2006.11.029
   Miguel M, 2006, LIFE SCI, V78, P2960, DOI 10.1016/j.lfs.2005.11.025
   Nagai T, 2006, J MED FOOD, V9, P363, DOI 10.1089/jmf.2006.9.363
   Okada Y, 1998, J AGR FOOD CHEM, V46, P401, DOI 10.1021/jf970470l
   Ou BX, 2001, J AGR FOOD CHEM, V49, P4619, DOI 10.1021/jf010586o
   Palmieri VO, 2006, J NUTR, V136, P3022, DOI 10.1093/jn/136.12.3022
   Pihlanto A, 2006, INT DAIRY J, V16, P1306, DOI 10.1016/j.idairyj.2006.06.005
   Pins Joel J, 2006, J Clin Hypertens (Greenwich), V8, P775, DOI 10.1111/j.1524-6175.2006.05667.x
   RODRIGUEZMARTINEZ MA, 1992, MECH AGEING DEV, V66, P213, DOI 10.1016/0047-6374(92)90137-3
   Saiga A, 2003, J AGR FOOD CHEM, V51, P3661, DOI 10.1021/jf021156g
   SAWADA M, 1992, J CELL BIOCHEM, V48, P296, DOI 10.1002/jcb.240480310
   Schiffrin EL, 2004, AM J PHYSIOL-HEART C, V287, pH435, DOI 10.1152/ajpheart.00262.2004
   Schnackenberg CG, 1998, HYPERTENSION, V32, P59, DOI 10.1161/01.HYP.32.1.59
   Suetsuna K, 2000, J NUTR BIOCHEM, V11, P128, DOI 10.1016/S0955-2863(99)00083-2
   SUZUKI S, 1993, PHARMACOLOGY, V47, P61, DOI 10.1159/000139079
   TSUGE N, 1991, NIPPON NOGEIK KAISHI, V65, P1635
   Virtanen T, 2007, J APPL MICROBIOL, V102, P106, DOI 10.1111/j.1365-2672.2006.03072.x
   Zhong F, 2007, FOOD RES INT, V40, P756, DOI 10.1016/j.foodres.2007.01.005
   Zhong F, 2007, FOOD RES INT, V40, P661, DOI 10.1016/j.foodres.2006.11.011
   Zhu KX, 2006, PROCESS BIOCHEM, V41, P1296, DOI 10.1016/j.procbio.2005.12.029
NR 46
TC 110
Z9 131
U1 1
U2 57
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0308-8146
EI 1873-7072
J9 FOOD CHEM
JI Food Chem.
PD JUL 15
PY 2008
VL 109
IS 2
BP 361
EP 367
DI 10.1016/j.foodchem.2007.12.049
PG 7
WC Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology; Nutrition & Dietetics
GA 285PW
UT WOS:000254789700015
PM 26003359
DA 2025-06-11
ER

PT J
AU Karuparthi, PR
   Yerram, P
   Lastra, G
   Hayden, MR
   Sowers, JR
AF Karuparthi, Poorna R.
   Yerram, Preethi
   Lastra, Guido
   Hayden, Melvin R.
   Sowers, James R.
TI Understanding essential hypertension from the perspective of the
   cardiometabolic syndrome
SO JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION
LA English
DT Review
DE Metabolic syndrome; microalbuminuria; endothelial dysfunction; insulin
   resistance; hyperinsulinemia
ID TYPE-2 DIABETES-MELLITUS; JOINT-NATIONAL-COMMITTEE;
   CORONARY-HEART-DISEASE; BLOOD-PRESSURE; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; CARDIOVASCULAR MORBIDITY; GUIDELINE UPDATE; RENIN INHIBITOR;
   DIETARY-SODIUM
AB Hypertension (HTN) is an important modifiable risk factor for major health problems such as coronary heart disease, stroke, congestive heart failure, end-stage renal disease, and peripheral vascular disease. Because of the associated morbidity and mortality, and the cost to society, HTN is an important public health challenge. HTN is frequently associated with other cardiovascular disease risk factors constituting the cardiometabolic syndrome, which individually and synergistically influence the pathophysiology of HTN, and the resultant increased redox stress contributes to the remodeling changes in key organs such as the heart and kidney. Remodeling at the subcellular level, and extracellular matrix in the heart and kidney of the hypertensive Ren2 transgenic rat model of tissue angiotensin II overexpression (TG(mREN-2)27), compared with the Sprague Dawley control rat model, has been observed by light and electron microscopy and are discussed. A better understanding of the pathophysiology of HTN may provide clinician and researcher, tools to effectively investigate and manage this complicated disease process. (C) 2007 American Society of Hypertension. All rights reserved.
C1 [Karuparthi, Poorna R.; Yerram, Preethi; Lastra, Guido; Hayden, Melvin R.] Univ Missouri, Dept Internal Med, Columbia, MO 65201 USA.
   [Hayden, Melvin R.] Univ Missouri, Div Endocrinol Diabet & Metab, Columbia, MO USA.
   [Yerram, Preethi; Lastra, Guido] Vet Affairs Med Ctr, Columbia, MO USA.
   [Sowers, James R.] Arizona Hlth Sci, Ctr Diabet, Div Endocrinol Diabet & Metab, Tucson, AZ USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   University of Arizona Health Sciences
RP Karuparthi, PR (corresponding author), Univ Missouri, Dept Internal Med, Columbia, MO 65201 USA.
EM rkaruparthi@yahoo.com
OI YERRAM, PREETHI/0000-0003-1232-4849
CR Ahima RS, 2000, TRENDS ENDOCRIN MET, V11, P327, DOI 10.1016/S1043-2760(00)00301-5
   *AM DIAB ASS, 2003, DIABETES CARE, V26, pS80, DOI DOI 10.2337/DIACARE.26.2007.S80
   Andersson PE, 1996, AM J HYPERTENS, V9, P323, DOI 10.1016/0895-7061(95)00396-7
   [Anonymous], 2022, JAMA, V288, P2981, DOI [10.1001/jama, 10.1001/jama.288.23.2981, DOI 10.1001/JAMA.288.23.2981]
   [Anonymous], HYP MAN HYP AD PRIM
   Bakris GL, 2000, ARCH INTERN MED, V160, P685, DOI 10.1001/archinte.160.5.685
   Bakris GL, 2003, ARCH INTERN MED, V163, P1555, DOI 10.1001/archinte.163.13.1555
   BAUM M, 1987, J CLIN INVEST, V79, P1104, DOI 10.1172/JCI112925
   Bell DSH, 2004, AM J CARDIOL, V93, p49B, DOI 10.1016/j.amjcard.2004.01.026
   Black Henry R, 2004, Clin Cornerstone, V6, P53, DOI 10.1016/S1098-3597(04)80078-4
   Black HR, 1997, ARCH INTERN MED, V157, P2413
   Black HR, 2001, HYPERTENSION, V37, P12, DOI 10.1161/01.HYP.37.1.12
   Bosch J, 2006, NEW ENGL J MED, V355, P1551
   Braunwald E, 2002, J AM COLL CARDIOL, V40, P1366, DOI 10.1016/S0735-1097(02)02336-7
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Cheng ZJ, 2001, HYPERTENSION, V37, P433, DOI 10.1161/01.HYP.37.2.433
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cushman William C, 2002, J Clin Hypertens (Greenwich), V4, P393
   Dahlöf B, 2002, LANCET, V359, P995, DOI 10.1016/S0140-6736(02)08089-3
   DEFRONZO RA, 1975, J CLIN INVEST, V55, P845, DOI 10.1172/JCI107996
   Expert Committee on the Diagnosis and Classification of Diabetes Mellitus, 2003, Diabetes Care, V26, pS5, DOI 10.2337/diacare.26.2007.S5
   Fesler P, 2004, HYPERTENSION, V43, P219, DOI 10.1161/01.HYP.0000109321.76818.14
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Gerstein HC, 2006, LANCET, V368, P1096, DOI 10.1016/S0140-6736(06)69420-8
   Gerstein HC, 2000, LANCET, V355, P253
   Giles Thomas D, 2005, J Clin Hypertens (Greenwich), V7, P505, DOI 10.1111/j.1524-6175.2005.04769.x
   Gradman AH, 2005, CIRCULATION, V111, P1012, DOI 10.1161/01.CIR.0000156466.02908.ED
   Gradman AH, 2006, CURR HYPERTENS REP, V8, P425, DOI 10.1007/s11906-006-0090-z
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Hajjar I, 2003, JAMA-J AM MED ASSOC, V290, P199, DOI 10.1001/jama.290.2.199
   HANSPETER B, 2005, J HYPERTENS, V23, P233
   Hayden M R Pete, 2006, Mo Med, V103, P533
   Hayden Melvin R, 2006, J Cardiometab Syndr, V1, P326, DOI 10.1111/j.1559-4564.2006.05626.x
   Hayden Melvin R, 2006, J Cardiometab Syndr, V1, P107, DOI 10.1111/j.1559-4564.2006.05625.x
   Hayden MR, 2007, AM J PHYSIOL-RENAL, V292, pF861, DOI 10.1152/ajprenal.00252.2006
   Hayden Melvin R, 2006, J Cardiometab Syndr, V1, P16, DOI 10.1111/j.0197-3118.2006.05454.x
   Hayden Melvin R, 2003, Med Sci Monit, V9, pSR35
   Hayden MR, 2005, AM J NEPHROL, V25, P553, DOI 10.1159/000088810
   Hayden MR., 2006, Insulin, V1, P22, DOI [10.1016/S1557-0843(06)80005-9, DOI 10.1016/S1557-0843(06)80005-9]
   He JA, 2000, HYPERTENSION, V35, P544, DOI 10.1161/01.HYP.35.2.544
   Hillege HL, 2002, CIRCULATION, V106, P1777, DOI 10.1161/01.CIR.0000031732.78052.81
   Hunt SA, 2005, CIRCULATION, V112, P1825, DOI 10.1161/CIRCULATIONAHA.105.167587
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jeppesen J, 1998, J INTERN MED, V243, P293
   Julius S, 2004, LANCET, V363, P2022, DOI 10.1016/S0140-6736(04)16451-9
   Kailasam MT, 2000, J HYPERTENS, V18, P1611, DOI 10.1097/00004872-200018110-00012
   Kannel WB., 2000, American journal of hypertension, V13, p3S, DOI DOI 10.1016/S0895-7061(99)00252-6
   Kaplan NM, 2004, HYPERTENSION, V44, P125, DOI 10.1161/01.HYP.0000136909.14661.7c
   Kern W, 2005, METABOLISM, V54, P391, DOI 10.1016/j.metabol.2004.10.005
   Khan N, 2006, CAN MED ASSOC J, V174, P1737, DOI 10.1503/cmaj.060110
   Lane JT, 2004, AM J PHYSIOL-RENAL, V286, pF442, DOI 10.1152/ajprenal.00247.2003
   Lebovitz HE, 2001, RECENT PROG HORM RES, V56, P265, DOI 10.1210/rp.56.1.265
   Lewington S, 2002, LANCET, V360, P1903, DOI 10.1016/S0140-6736(02)11911-8
   Lithell HO, 1996, AM J HYPERTENS, V9, pS150, DOI 10.1016/0895-7061(96)00290-7
   Maclsaac RJ, 2004, CURR OPIN NEPHROL HY, V13, P83, DOI 10.1097/01.mnh.0000109587.66112.3c
   MACMAHON S, 1990, LANCET, V335, P765, DOI 10.1016/0140-6736(90)90878-9
   Manrique Camila, 2005, J Clin Hypertens (Greenwich), V7, P471, DOI 10.1111/j.1524-6175.2005.04617.x
   McFarlane SI, 2001, J CLIN ENDOCR METAB, V86, P713, DOI 10.1210/jc.86.2.713
   Nickenig G, 1998, CIRCULATION, V98, P2453, DOI 10.1161/01.CIR.98.22.2453
   Niklason A, 2004, J HYPERTENS, V22, P645, DOI 10.1097/00004872-200403000-00029
   Niskanen L, 2001, DIABETES CARE, V24, P2091, DOI 10.2337/diacare.24.12.2091
   Pfeffer MA, 2003, LANCET, V362, P759, DOI 10.1016/S0140-6736(03)14282-1
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   RION F, 1985, SCHWEIZ MED WSCHR, V115, P1829
   Sacks FM, 2001, NEW ENGL J MED, V344, P3, DOI 10.1056/NEJM200101043440101
   Safar ME, 2003, CIRCULATION, V107, P2864, DOI 10.1161/01.CIR.0000069826.36125.B4
   Sarafidis PA, 2006, AM J HYPERTENS, V19, P646, DOI 10.1016/j.amjhyper.2005.12.017
   SCOTT M, 2000, ENDOCRINE, V13, P155
   Sharma AM, 2006, AM J MED, V119, p17S, DOI 10.1016/j.amjmed.2006.01.010
   Sharma AM, 2002, INT J OBESITY, V26, pS5, DOI 10.1038/sj.ijo.0802210
   Sharma AM, 2002, HYPERTENSION, V40, P609, DOI 10.1161/01.HYP.0000036448.44066.53
   SISCOVICK DS, 1994, NEW ENGL J MED, V330, P1852, DOI 10.1056/NEJM199406303302603
   Sowers J R, 2001, Clin Cornerstone, V4, P17, DOI 10.1016/S1098-3597(01)90026-2
   Sowers JR, 2004, AM J PHYSIOL-HEART C, V286, pH1597, DOI 10.1152/ajpheart.00026.2004
   Sowers JR, 2003, AM J HYPERTENS, V16, p41S, DOI 10.1016/S0895-7061(03)01071-9
   STAMLER J, 1993, ARCH INTERN MED, V153, P598, DOI 10.1001/archinte.153.5.598
   STANDLEY PR, 1995, AM J HYPERTENS, V8, P48, DOI 10.1016/0895-7061(94)00160-D
   Stanton A, 2003, HYPERTENSION, V42, P1137, DOI 10.1161/01.HYP.0000101688.17370.87
   Vasan RS, 2002, JAMA-J AM MED ASSOC, V287, P1003, DOI 10.1001/jama.287.8.1003
   VILLARREAL FJ, 1995, HYPERTENSION, V25, P98, DOI 10.1161/01.HYP.25.1.98
   Wang YF, 2004, ARCH INTERN MED, V164, P2126, DOI 10.1001/archinte.164.19.2126
   Whaley-Connell A, 2005, ENDOCRIN METAB CLIN, V34, P63, DOI 10.1016/j.ecl.2004.11.007
   Whelton PK, 1997, ARCH INTERN MED, V157, P657, DOI 10.1001/archinte.157.6.657
   Wilson PWF, 1998, CIRCULATION, V97, P1837, DOI 10.1161/01.CIR.97.18.1837
   Wolf G, 2002, AM J KIDNEY DIS, V39, P1, DOI 10.1053/ajkd.2002.29865
   Yusuf S, 2000, NEW ENGL J MED, V342, P145
   Zanella MT, 2001, HYPERTENSION, V38, P705, DOI 10.1161/01.HYP.38.3.705
   Zillich AJ, 2006, HYPERTENSION, V48, P219, DOI 10.1161/01.HYP.0000231552.10054.aa
NR 90
TC 4
Z9 4
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1933-1711
EI 1878-7436
J9 J AM SOC HYPERTENS
JI J. Am. Soc. Hypertens.
PD MAR-APR
PY 2007
VL 1
IS 2
BP 120
EP 134
DI 10.1016/j.jash.2007.01.006
PG 15
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA V18KL
UT WOS:000208003600006
PM 20409842
DA 2025-06-11
ER

PT J
AU Ashraf, NU
   Sheikh, TA
AF Ashraf, N. U.
   Sheikh, T. A.
TI Endoplasmic reticulum stress and Oxidative stress in the pathogenesis of
   Non-alcoholic fatty liver disease
SO FREE RADICAL RESEARCH
LA English
DT Review
DE ER stress; Oxidative stress; cell death; Non-alcoholic Fatty liver
   disease
ID UNFOLDED PROTEIN RESPONSE; RANDOMIZED CONTROLLED-TRIAL;
   PLACEBO-CONTROLLED-TRIAL; BZIP TRANSCRIPTION FACTORS; LIPID DROPLET
   FORMATION; DOUBLE-EDGED-SWORD; ER STRESS; VITAMIN-E; HEPATIC STEATOSIS;
   INSULIN-RESISTANCE
AB Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome. The underlying causes of the disease progression in NAFLD are unclear. Recent evidences suggest endoplasmic reticulum stress in the development of lipid droplets (steatosis) and subsequent generation of reactive oxygen species (ROS) in the progression to non-alcoholic steatohepatitis (NASH). The signalling pathway activated by disruption of endoplasmic reticulum (ER) homoeostasis, called as unfolded protein response, is linked with membrane biosynthesis, insulin action, inflammation and apoptosis. ROS are important mediators of inflammation. Protein folding in ER is linked to ROS. Therefore understanding the basic mechanisms that lead to ER stress and ROS in NAFLD have become the topics of immense interest. The present review focuses on the role of ER stress and ROS in the pathogenesis of NAFLD. We also highlight the cross talk between ER stress and oxidative stress which suggest and encourage the development of therapeutics for NAFLD. Further we have reviewed various strategies used for the management of NAFLD/NASH and limitations of such strategies. Our review therefore highlights the need for newer strategies with regards to ER stress and oxidative stress.
C1 [Ashraf, N. U.; Sheikh, T. A.] Acad Sci & Innovat Res AcSIR, New Delhi, India.
   [Ashraf, N. U.; Sheikh, T. A.] CSIR, Indian Inst Integrat Med, PK PD & Toxicol Div, Jammu, Jammu & Kashmir, India.
   [Sheikh, T. A.] PK PD & Toxicol Div, Jammu, India.
C3 Academy of Scientific & Innovative Research (AcSIR); Council of
   Scientific & Industrial Research (CSIR) - India; CSIR - Indian Institute
   of Integrative Medicine (IIIM)
RP Sheikh, TA (corresponding author), CSIR, Indian Inst Integrat Med, Canal Rd, Jammu, Jammu & Kashmir, India.
EM stabdullah@iiim.ac.in
FU Council of Scientific and Industrial research (CSIR), New Delhi;
   University Grants Commission (UGC), New Delhi
FX Council of Scientific and Industrial research (CSIR), New Delhi and
   University Grants Commission (UGC), New Delhi are acknowledged for
   financial assistance.
CR Adams LA, 2004, AM J GASTROENTEROL, V99, P2365, DOI 10.1111/j.1572-0241.2004.40064.x
   Aithal GP, 2008, GASTROENTEROLOGY, V135, P1176, DOI 10.1053/j.gastro.2008.06.047
   Akyüz F, 2007, DIGEST DIS SCI, V52, P2359, DOI 10.1007/s10620-006-9145-x
   Albano E, 2005, ALIMENT PHARM THER, V22, P71, DOI 10.1111/j.1365-2036.2005.02601.x
   Amemiya-Kudo M, 2002, J LIPID RES, V43, P1220, DOI 10.1194/jlr.M100417-JLR200
   Anderson EK, 2012, ARTERIOSCL THROM VAS, V32, P1687, DOI 10.1161/ATVBAHA.112.250142
   Anderson N, 2008, PHARMACOL REV, V60, P311, DOI 10.1124/pr.108.00001
   Asada R, 2011, J BIOCHEM, V149, P507, DOI 10.1093/jb/mvr041
   Ascha MS, 2010, HEPATOLOGY, V51, P1972, DOI 10.1002/hep.23527
   Aubert J, 2011, CLIN RES HEPATOL GAS, V35, P630, DOI 10.1016/j.clinre.2011.04.015
   Bailey D, 2007, ANTIOXID REDOX SIGN, V9, P2305, DOI 10.1089/ars.2007.1796
   Begriche K, 2006, MITOCHONDRION, V6, P1, DOI 10.1016/j.mito.2005.10.004
   Belfort R, 2006, NEW ENGL J MED, V355, P2297, DOI 10.1056/NEJMoa060326
   Belmont PJ, 2012, J MOL CELL CARDIOL, V52, P1176, DOI 10.1016/j.yjmcc.2012.01.017
   Bobrovnikova-Marjon E, 2008, P NATL ACAD SCI USA, V105, P16314, DOI 10.1073/pnas.0808517105
   Bravo R, 2013, INT REV CEL MOL BIO, V301, P215, DOI 10.1016/B978-0-12-407704-1.00005-1
   Brown MS, 1997, CELL, V89, P331, DOI 10.1016/S0092-8674(00)80213-5
   Bugianesi E, 2005, AM J GASTROENTEROL, V100, P1082, DOI 10.1111/j.1572-0241.2005.41583.x
   Bujanda L, 2008, BMC GASTROENTEROL, V8, DOI 10.1186/1471-230X-8-40
   Caldwell SH, 1999, J HEPATOL, V31, P430, DOI 10.1016/S0168-8278(99)80033-6
   Cao J, 2012, MOL CELL BIOCHEM, V364, P115, DOI 10.1007/s11010-011-1211-9
   Cao SS, 2014, ANTIOXID REDOX SIGN, V21, P396, DOI 10.1089/ars.2014.5851
   Capanni M, 2006, ALIMENT PHARM THER, V23, P1143, DOI 10.1111/j.1365-2036.2006.02885.x
   Carmiel-Haggai M, 2004, FASEB J, V18, P136, DOI 10.1096/fj.04-2291fje
   Catalgol B, 2012, FRONT PHARMACOL, V3, DOI 10.3389/fphar.2012.00141
   Chalasani N, 2012, HEPATOLOGY, V55, P2005, DOI 10.1002/hep.25762
   Chalasani N, 2012, GASTROENTEROLOGY, V142, P1592, DOI 10.1053/j.gastro.2012.04.001
   Charlton M, 2011, AM J PHYSIOL-GASTR L, V301, pG825, DOI 10.1152/ajpgi.00145.2011
   Charlton MR, 2011, GASTROENTEROLOGY, V141, P1249, DOI 10.1053/j.gastro.2011.06.061
   Cinaroglu A, 2011, HEPATOLOGY, V54, P495, DOI 10.1002/hep.24396
   Colgan SM, 2011, EXPERT REV MOL MED, V13, DOI 10.1017/S1462399410001742
   CREIGHTON TE, 1980, J MOL BIOL, V142, P43, DOI 10.1016/0022-2836(80)90205-3
   Cullinan SB, 2004, J BIOL CHEM, V279, P20108, DOI 10.1074/jbc.M314219200
   Davies MJ, 2011, J CLIN BIOCHEM NUTR, V48, P8, DOI 10.3164/jcbn.11-006FR
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   De Minicis S, 2010, HEPATOLOGY, V52, P1420, DOI 10.1002/hep.23804
   Del Ben M, 2014, BMC GASTROENTEROL, V14, DOI 10.1186/1471-230X-14-81
   Deng XM, 2001, J BIOL CHEM, V276, P23681, DOI 10.1074/jbc.M100279200
   Dentin R, 2005, BIOCHIMIE, V87, P81, DOI 10.1016/j.biochi.2004.11.008
   DeZwaan-McCabe D, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003937
   Diehl JA, 2011, GASTROENTEROLOGY, V141, P38, DOI 10.1053/j.gastro.2011.05.018
   Eberlé D, 2004, BIOCHIMIE, V86, P839, DOI 10.1016/j.biochi.2004.09.018
   Engelking LJ, 2004, J CLIN INVEST, V113, P1168, DOI 10.1172/JCI200420978
   Erhardt A, 2011, EUR J MED RES, V16, P76, DOI 10.1186/2047-783X-16-2-76
   Fan JG, 2013, J GASTROEN HEPATOL, V28, P81, DOI 10.1111/jgh.12244
   Farrukh MR, 2014, J DERMATOL SCI, V75, P24, DOI 10.1016/j.jdermsci.2014.03.005
   Fribley A, 2009, METHODS MOL BIOL, V559, P191, DOI 10.1007/978-1-60327-017-5_14
   Fu SN, 2012, CELL METAB, V15, P623, DOI 10.1016/j.cmet.2012.03.007
   Gentile CL, 2011, BIOFACTORS, V37, P8, DOI 10.1002/biof.135
   Gentile CL, 2011, ANTIOXID REDOX SIGN, V15, P505, DOI 10.1089/ars.2010.3790
   Gómez-Domínguez E, 2006, ALIMENT PHARM THER, V23, P1643, DOI 10.1111/j.1365-2036.2006.02926.x
   Gregor MF, 2009, DIABETES, V58, P693, DOI 10.2337/db08-1220
   Gu XM, 2010, LIFE SCI, V87, P724, DOI 10.1016/j.lfs.2010.10.012
   Guichard C, 2008, BIOCHEM SOC T, V36, P920, DOI 10.1042/BST0360920
   Harrison SA, 2003, AM J GASTROENTEROL, V98, P2485, DOI 10.1111/j.1572-0241.2003.08699.x
   Hassler J, 2012, DEV CELL, V23, P921, DOI 10.1016/j.devcel.2012.10.025
   Haukeland JW, 2009, SCAND J GASTROENTERO, V44, P853, DOI 10.1080/00365520902845268
   Hennig EE, 2014, J CELL MOL MED
   Herrera E, 2001, J PHYSIOL BIOCHEM, V57, P43, DOI 10.1007/BF03179812
   Higa A, 2012, CELL SIGNAL, V24, P1548, DOI 10.1016/j.cellsig.2012.03.011
   Hollien J, 2009, J CELL BIOL, V186, P323, DOI 10.1083/jcb.200903014
   Horton JD, 2002, COLD SPRING HARB SYM, V67, P491, DOI 10.1101/sqb.2002.67.491
   Horton JD, 2002, J CLIN INVEST, V109, P1125, DOI 10.1172/JCI200215593
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   Hyogo H, 2008, METABOLISM, V57, P1711, DOI 10.1016/j.metabol.2008.07.030
   Jiang JX, 2014, ADV HEPATOLOGY
   Jiang S, 2014, J BIOL CHEM
   Jo H, 2013, HEPATOLOGY, V57, P1366, DOI 10.1002/hep.26126
   Kammoun HL, 2009, J CLIN INVEST, V119, P1201, DOI 10.1172/JCI37007
   Kaplowitz N, 2007, SEMIN LIVER DIS, V27, P367, DOI 10.1055/s-2007-991513
   Klein EA, 2011, JAMA-J AM MED ASSOC, V306, P1549, DOI 10.1001/jama.2011.1437
   Kober L, 2012, BIOTECHNOL BIOENG, V109, P2599, DOI 10.1002/bit.24527
   Koek GH, 2011, CLIN CHIM ACTA, V412, P1297, DOI 10.1016/j.cca.2011.04.013
   Lauressergues E, 2012, NEUROPHARMACOLOGY, V62, P784, DOI 10.1016/j.neuropharm.2011.08.048
   Laurindo FRM, 2014, ANTIOXID REDOX SIGN, V20, P2755, DOI 10.1089/ars.2013.5605
   Lavine JE, 2000, J PEDIATR-US, V136, P734, DOI 10.1016/S0022-3476(00)05040-X
   Lavine JE, 2011, JAMA-J AM MED ASSOC, V305, P1659, DOI 10.1001/jama.2011.520
   Leclercq GRI, 2001, AM J PHYSIOL-GASTR L, V281, pG1135
   Lee AH, 2008, SCIENCE, V320, P1492, DOI 10.1126/science.1158042
   Lee JS, 2012, TOXICOL LETT, V211, P29, DOI 10.1016/j.toxlet.2012.02.017
   Lee JN, 2004, J BIOL CHEM, V279, P45257, DOI 10.1074/jbc.M408235200
   Lei K, 2003, P NATL ACAD SCI USA, V100, P2432, DOI 10.1073/pnas.0438011100
   Leung T, 2013, BREAST CANCER RES, V15, DOI 10.1186/bcr3574
   Li G, 2009, J CELL BIOL, V186, P783, DOI 10.1083/jcb.200904060
   Li HK, 2011, BIOCHEM J, V438, P283, DOI 10.1042/BJ20110263
   Li J, 2012, J HEPATOL, V56, P900, DOI 10.1016/j.jhep.2011.10.018
   Li Y, 2012, INT J OBESITY, V36, P1503, DOI 10.1038/ijo.2011.279
   Lieber CS, 1997, PHYSIOL REV, V77, P517, DOI 10.1152/physrev.1997.77.2.517
   Lin HZ, 2000, NAT MED, V6, P998, DOI 10.1038/79697
   Liu Q, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0085660
   Liu SL, 2011, J GASTROEN HEPATOL, V26, P1010, DOI 10.1111/j.1440-1746.2011.06672.x
   Lomonaco R, 2013, DRUGS, V73, P1, DOI 10.1007/s40265-012-0004-0
   Malhi H, 2011, J HEPATOL, V54, P795, DOI 10.1016/j.jhep.2010.11.005
   Malhotra JD, 2007, ANTIOXID REDOX SIGN, V9, P2277, DOI 10.1089/ars.2007.1782
   Marchesini G, 2001, LANCET, V358, P893, DOI 10.1016/S0140-6736(01)06042-1
   Marí M, 2006, CELL METAB, V4, P185, DOI 10.1016/j.cmet.2006.07.006
   Matsuzawa N, 2007, HEPATOLOGY, V46, P1392, DOI 10.1002/hep.21874
   McCullough KD, 2001, MOL CELL BIOL, V21, P1249, DOI 10.1128/MCB.21.4.1249-1259.2001
   Miller ER, 2005, ANN INTERN MED, V142, P37, DOI 10.7326/0003-4819-142-1-200501040-00110
   Montane J, 2014, DIABET METAB SYND OB, V7, P25, DOI 10.2147/DMSO.S37649
   Negre-Salvayre A, 2010, FREE RADICAL RES, V44, P1125, DOI 10.3109/10715762.2010.498478
   Nelson A, 2009, J CLIN GASTROENTEROL, V43, P990, DOI 10.1097/MCG.0b013e31819c392e
   Niki E, 2009, FREE RADICAL BIO MED, V47, P469, DOI 10.1016/j.freeradbiomed.2009.05.032
   Nissar AU, 2015, TOXICOLOGY RES
   Novoa I, 2001, J CELL BIOL, V153, P1011, DOI 10.1083/jcb.153.5.1011
   Nseir W, 2014, WORLD J GASTROENTERO, V20, P9338, DOI 10.3748/wjg.v20.i28.9338
   Oh S, 2014, METAB SYNDR RELAT D, V12, P290, DOI 10.1089/met.2013.0143
   Ota T, 2008, J CLIN INVEST, V118, P316, DOI 10.1172/JCI32752
   Oyadomari S, 2004, CELL DEATH DIFFER, V11, P381, DOI 10.1038/sj.cdd.4401373
   Oyadomari S, 2008, CELL METAB, V7, P520, DOI 10.1016/j.cmet.2008.04.011
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Pagliassotti MJ, 2012, ANNU REV NUTR, V32, P17, DOI 10.1146/annurev-nutr-071811-150644
   Paik YH, 2014, ANTIOXID REDOX SIGN, V20, P2854, DOI 10.1089/ars.2013.5619
   Palomer X, 2014, CLIN INVESTIG ARTERI
   Pincus D, 2010, PLOS BIOL, V8, DOI 10.1371/journal.pbio.1000415
   Pollard MG, 1998, MOL CELL, V1, P171, DOI 10.1016/S1097-2765(00)80018-0
   Puri P, 2008, GASTROENTEROLOGY, V134, P568, DOI 10.1053/j.gastro.2007.10.039
   Puthalakath H, 2007, CELL, V129, P1337, DOI 10.1016/j.cell.2007.04.027
   Qiu W, 2009, J LIPID RES, V50, P1814, DOI 10.1194/jlr.M800343-JLR200
   Rahman SM, 2007, HEPATOLOGY, V45, P1108, DOI 10.1002/hep.21614
   Ratziu V, 2008, GASTROENTEROLOGY, V135, P100, DOI 10.1053/j.gastro.2008.03.078
   Rawson RB, 2003, NAT REV MOL CELL BIO, V4, P631, DOI 10.1038/nrm1174
   Rolo AP, 2012, FREE RADICAL BIO MED, V52, P59, DOI 10.1016/j.freeradbiomed.2011.10.003
   Ron D, 2008, CELL, V132, P24, DOI 10.1016/j.cell.2007.12.017
   Ron D, 2007, NAT REV MOL CELL BIO, V8, P519, DOI 10.1038/nrm2199
   Rutkowski DT, 2008, DEV CELL, V15, P829, DOI 10.1016/j.devcel.2008.10.015
   Sahini N, 2014, PROG LIPID RES, V54, P86, DOI 10.1016/j.plipres.2014.02.002
   Sakai J, 1998, J BIOL CHEM, V273, P5785, DOI 10.1074/jbc.273.10.5785
   Sano R, 2013, BBA-MOL CELL RES, V1833, P3460, DOI 10.1016/j.bbamcr.2013.06.028
   Santos CXC, 2009, ANTIOXID REDOX SIGN, V11, P2409, DOI [10.1089/ars.2009.2625, 10.1089/ARS.2009.2625]
   Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929
   Satapathy SK, 2007, J GASTROEN HEPATOL, V22, P634, DOI 10.1111/j.1440-1746.2006.04756.x
   Schattenberg JM, 2011, CURR OPIN LIPIDOL, V22, P479, DOI 10.1097/MOL.0b013e32834c7cfc
   Schröder M, 2008, CELL MOL LIFE SCI, V65, P862, DOI 10.1007/s00018-007-7383-5
   Seo J, 2009, DIABETES, V58, P2565, DOI 10.2337/db09-0335
   Shang J, 2008, ACTA PHARMACOL SIN, V29, P698, DOI 10.1111/j.1745-7254.2008.00807.x
   Sreejayan N, 2008, OBESITY, V16, P1331, DOI 10.1038/oby.2008.217
   Sumida Y, 2013, FREE RADICAL RES, V47, P869, DOI 10.3109/10715762.2013.837577
   Suyama K, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0086951
   Svegliati-Baroni G, 2006, AM J PATHOL, V169, P846, DOI 10.2353/ajpath.2006.050953
   Tabas I, 2011, NAT CELL BIOL, V13, P184, DOI 10.1038/ncb0311-184
   Takahashi Y, 2015, WORLD J GASTROENTERO, V21, P3777, DOI 10.3748/wjg.v21.i13.3777
   Takaishi K, 2004, P NATL ACAD SCI USA, V101, P7106, DOI 10.1073/pnas.0401715101
   Tamaki N, 2008, AM J PHYSIOL-GASTR L, V294, pG498, DOI 10.1152/ajpgi.00482.2007
   Tanaka N, 2008, J CLIN GASTROENTEROL, V42, P413, DOI 10.1097/MCG.0b013e31815591aa
   Tariq Z, 2014, LIVER INT
   Toriguchi K, 2014, J GASTROEN HEPATOL, V29, P1109, DOI 10.1111/jgh.12481
   Tu BP, 2004, J CELL BIOL, V164, P341, DOI 10.1083/jcb.200311055
   Usui M, 2012, METABOLISM, V61, P1118, DOI 10.1016/j.metabol.2012.01.004
   Van Wagner LB, 2011, ANN HEPATOL, V10, P277, DOI 10.1016/S1665-2681(19)31539-X
   Videla LA, 2004, CLIN SCI, V106, P261, DOI 10.1042/CS20030285
   Walter P, 2011, SCIENCE, V334, P1081, DOI 10.1126/science.1209038
   Wan XS, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/807874
   Wang CX, 2010, CELL RES, V20, P174, DOI 10.1038/cr.2010.4
   Wang D, 2006, ENDOCRINOLOGY, V147, P943, DOI 10.1210/en.2005-0570
   Wang SY, 2012, CELL METAB, V16, P473, DOI 10.1016/j.cmet.2012.09.003
   Woodcroft KJ, 1999, BIOCHEM BIOPH RES CO, V266, P304, DOI 10.1006/bbrc.1999.1817
   Xiao GZ, 2013, J BIOL CHEM, V288, P25350, DOI 10.1074/jbc.M113.470526
   Xu CY, 2005, J CLIN INVEST, V115, P2656, DOI 10.1172/JCI26373
   Yamaguchi H, 2004, J BIOL CHEM, V279, P45495, DOI 10.1074/jbc.M406933200
   Yamamoto K, 2010, MOL BIOL CELL, V21, P2975, DOI 10.1091/mbc.E09-02-0133
   Yang L, 2007, LAB INVEST, V87, P927, DOI 10.1038/labinvest.3700603
   Yang T, 2002, CELL, V110, P489, DOI 10.1016/S0092-8674(02)00872-3
   Ye J, 2000, MOL CELL, V6, P1355, DOI 10.1016/S1097-2765(00)00133-7
   Yoneda M, 2010, HEPATOL RES, V40, P566, DOI 10.1111/j.1872-034X.2010.00644.x
   Zein CO, 2012, HEPATOLOGY, V56, P1291, DOI 10.1002/hep.25778
   Zeng LF, 2004, EMBO J, V23, P950, DOI 10.1038/sj.emboj.7600106
   Zha BS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059514
   Zhang KZ, 2008, NATURE, V454, P455, DOI 10.1038/nature07203
   Zhang KZ, 2011, EMBO J, V30, P1357, DOI 10.1038/emboj.2011.52
   Zhang XQ, 2014, WORLD J GASTROENTERO, V20, P1768, DOI 10.3748/wjg.v20.i7.1768
   Zhou HP, 2014, FRONT GENET, V5, DOI 10.3389/fgene.2014.00112
NR 172
TC 244
Z9 279
U1 6
U2 111
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PY 2015
VL 49
IS 12
BP 1405
EP 1418
DI 10.3109/10715762.2015.1078461
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DD4KW
UT WOS:000369892800001
PM 26223319
DA 2025-06-11
ER

PT J
AU Wang, J
   Sereika, SM
   Styn, MA
   Burke, LE
AF Wang, Jing
   Sereika, Susan M.
   Styn, Mindi A.
   Burke, Lora E.
TI Factors associated with health-related quality of life among overweight
   or obese adults
SO JOURNAL OF CLINICAL NURSING
LA English
DT Article
DE barriers; health-related quality of life; obesity; self-efficacy; Short
   Form-36 Health Survey; stress
ID BODY-MASS INDEX; LOW-ENERGY DIET; WEIGHT-LOSS; BEHAVIOR-MODIFICATION;
   METABOLIC SYNDROME; LOSING WEIGHT; US ADULTS; MAINTENANCE; TRIAL; COST
AB Aims and objectives To identify factors associated with health-related quality of life among overweight or obese adults.
   Background The obesity epidemic presents a global challenge. Obesity is associated with lower health-related quality of life; however, no study has comprehensively examined correlates of health-related quality of life in this population.
   Design A cross-sectional design.
   Methods The physical component score, mental component score and eight domain scores of the Short Form-36 v2 were used to assess health-related quality of life. We identified 23 possible correlates of health-related quality of life, including age, body mass index, health and weight histories, perceived stress, cholesterol-lowering diet self-efficacy, problem-solving, binge eating, dietary intake and physical activity. Correlational analyses were used to examine the bivariate associations between correlates and health-related quality of life variables. All possible subsets regression was used to develop predictive models of health-related quality of life.
   Results The sample (n=210) was predominantly White (848%), female (781%) and middle-aged (average age=4680years). Age, body mass index, education, having children at home, and being hypertensive were identified as the best predictors of physical component score, explaining about 9% of the variance. Age, marital status, having hyperlipidaemia, perceived stress, problem-solving, self-efficacy, binge eating and barriers to healthy eating predicted mental component score, explaining approximately 48% of the variance. Physical functioning and role physical domains of health-related quality of life had similar sets of predictors, with 15% and 13% of the variance explained, respectively, while similar predictors were identified for bodily pain (6%), general health (26%), vitality (40%), social functioning (32%), role emotional (42%) and mental health (46%) domains.
   Conclusions Psychosocial factors were associated with the mental-related quality of life. Further exploration of factors related to physical-related quality of life is warranted in this population.
   Relevance to clinical practiceWhen working with overweight/obese adults who are trying to lose weight, nurses need to consider socio-demographic and psychosocial factors in the development of a treatment plan that will improve health-related quality of life in this population.
C1 [Wang, Jing] Univ Texas Hlth Sci Ctr Houston, Sch Nursing, Dept Nursing Syst, Houston, TX 77030 USA.
   [Sereika, Susan M.; Styn, Mindi A.; Burke, Lora E.] Univ Pittsburgh, Sch Nursing, Dept Hlth & Community Syst, Pittsburgh, PA 15261 USA.
C3 University of Texas System; University of Texas Health Science Center
   Houston; Pennsylvania Commonwealth System of Higher Education (PCSHE);
   University of Pittsburgh
RP Wang, J (corresponding author), Univ Texas Hlth Sci Ctr Houston, Sch Nursing, Dept Nursing Syst, 6901 Bertner Ave,SON Room 614, Houston, TX 77030 USA.
EM Jing.Wang@uth.tmc.edu
FU NIH/NIDDK [R01 DK071817]; Data Management Core of the Center for
   Research in Chronic Disorders NIH-NINR [P30-NR03924]; General Clinical
   Research Center, NIH-NCRR-GCRC [5M01-RR000056]; Clinical Translational
   Research Center, NIH/NCRR/CTSA at the University of Pittsburgh [UL1
   RR024153]; NIH/NINR [K24-NR010742]
FX The parent study was supported by NIH/NIDDK # R01 DK071817. The conduct
   of the parent study was also supported by the Data Management Core of
   the Center for Research in Chronic Disorders NIH-NINR #P30-NR03924, the
   General Clinical Research Center, NIH-NCRR-GCRC #5M01-RR000056 and the
   Clinical Translational Research Center, NIH/NCRR/CTSA Grant UL1 RR024153
   at the University of Pittsburgh. This work was supported by NIH/NINR
   K24-NR010742 for LE Burke and J Wang.
CR Adachi Y, 2007, BEHAV RES THER, V45, P459, DOI 10.1016/j.brat.2006.03.017
   Algul A, 2009, INT J PSYCHIAT MED, V39, P297, DOI 10.2190/PM.39.3.f
   Anderson JW, 2001, AM J CLIN NUTR, V74, P579
   [Anonymous], 2012, Obesity and overweight
   Azadbakht L, 2007, BRIT J NUTR, V97, P399, DOI 10.1017/S0007114507328602
   Baiardi F, 2005, Eat Weight Disord, V10, P19
   Bish CL, 2006, OBESITY, V14, P2042, DOI 10.1038/oby.2006.239
   Blissmer B, 2006, HEALTH QUAL LIFE OUT, V4, DOI 10.1186/1477-7525-4-43
   Burke L.E., 2004, Annals of Behavioral Medicine, V27, pS101
   Burke Lora E, 2006, Eur J Cardiovasc Nurs, V5, P264, DOI 10.1016/j.ejcnurse.2006.03.005
   Burke Lora E, 2003, Eur J Cardiovasc Nurs, V2, P265, DOI 10.1016/S1474-5151(03)00093-8
   Burke LE, 2009, CONTEMP CLIN TRIALS, V30, P540, DOI 10.1016/j.cct.2009.07.003
   Buzzard IM, 1995, QUALITY AND ACCESSIBILITY OF FOOD-RELATED DATA, P241
   Caruso LB, 2000, J GERONTOL A-BIOL, V55, pM372, DOI 10.1093/gerona/55.7.M372
   Cohen J., 1988, STAT POWER ANAL BEHA, DOI [10.4324/9780203771587, DOI 10.4324/9780203771587]
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Corica F, 2008, INT J OBESITY, V32, P185, DOI 10.1038/sj.ijo.0803687
   Corica F, 2006, OBESITY, V14, P1429, DOI 10.1038/oby.2006.162
   Cussler EC, 2008, OBESITY, V16, P1052, DOI 10.1038/oby.2008.19
   D'Zurilla T.J., 1990, Psychological Assessment, V2, P156, DOI [10.1037/1040-3590.2.2.156, DOI 10.1037/1040-3590.2.2.156]
   GORMALLY J, 1982, ADDICT BEHAV, V7, P47, DOI 10.1016/0306-4603(82)90024-7
   Höfer S, 2005, PSYCHOSOMATICS, V46, P212, DOI 10.1176/appi.psy.46.3.212
   Hughes M, 1998, AM SOCIOL REV, V63, P785, DOI 10.2307/2657501
   Jia HM, 2005, J PUBLIC HEALTH-UK, V27, P156, DOI 10.1093/pubmed/fdi025
   Kaukua J, 2003, INT J OBESITY, V27, P1072, DOI 10.1038/sj.ijo.0802366
   Kaukua J, 2002, INT J OBESITY, V26, P487, DOI 10.1038/sj.ijo.0801953
   Kolotkin RL, 2009, HEALTH QUAL LIFE OUT, V7, DOI 10.1186/1477-7525-7-53
   KRISKA AM, 1990, DIABETES CARE, V13, P401, DOI 10.2337/diacare.13.4.401
   Kriska AM., 1997, MED SCI SPORT EXER, V29, pS5, DOI [DOI 10.1097/00005768-199706001-00003, 10.1097/00005768-199706001-00003]
   Lee DTF, 2005, EUR J HEART FAIL, V7, P419, DOI 10.1016/j.ejheart.2004.08.004
   Lemoine S, 2007, MENOPAUSE, V14, P432, DOI 10.1097/gme.0b013e31802e46c2
   Li CY, 2008, VALUE HEALTH, V11, P689, DOI 10.1111/j.1524-4733.2007.00307.x
   Luttik ML, 2006, HEART LUNG, V35, P3, DOI 10.1016/j.hrtlng.2005.08.001
   Maciejewski ML, 2005, J CLIN EPIDEMIOL, V58, P568, DOI 10.1016/j.jclinepi.2004.10.015
   MCHORNEY CA, 1994, MED CARE, V32, P40, DOI 10.1097/00005650-199401000-00004
   Mokdad A. H., 2003, JAMA, Journal of the American Medical Association, V289, P76, DOI 10.1001/jama.289.1.76
   Ogden CL, 2012, JAMA-J AM MED ASSOC, V307, P483, DOI [10.1001/jama.2012.39, 10.1001/jama.2012.40]
   Prasanna SJ, 2010, PLOS ONE, V5, DOI [10.1371/journal.pone.0014189, 10.1371/journal.pone.0009016]
   Rejeski WJ, 2006, OBESITY, V14, P870, DOI 10.1038/oby.2006.101
   Sach TH, 2007, INT J OBESITY, V31, P189, DOI 10.1038/sj.ijo.0803365
   Schulz L O, 1994, Obes Res, V2, P541
   Sousa KH, 1999, J ADV NURS, V29, P178, DOI 10.1046/j.1365-2648.1999.00877.x
   Stucki A, 2006, INT J OBESITY, V30, P1791, DOI 10.1038/sj.ijo.0803335
   Tsai AG, 2008, OBESITY, V16, P59, DOI 10.1038/oby.2007.8
   Wang YF, 2008, OBESITY, V16, P2323, DOI 10.1038/oby.2008.351
   Ware J., 2000, How to score version 2 of the SF-36 health survey
   Williams D. R., 1997, J HEALTH PSYCHOL, V2, P335, DOI DOI 10.1177/135910539700200305
   WILSON IB, 1995, JAMA-J AM MED ASSOC, V273, P59, DOI 10.1001/jama.273.1.59
   Wolf AM, 1998, OBES RES, V6, P97, DOI 10.1002/j.1550-8528.1998.tb00322.x
   Zeller MH, 2006, OBESITY, V14, P122, DOI 10.1038/oby.2006.15
NR 50
TC 37
Z9 54
U1 0
U2 49
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1067
EI 1365-2702
J9 J CLIN NURS
JI J. Clin. Nurs.
PD AUG
PY 2013
VL 22
IS 15-16
BP 2172
EP 2182
DI 10.1111/jocn.12280
PG 11
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 176UU
UT WOS:000321332100010
PM 23829404
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Arruda, HS
   Neri-Numa, IA
   Kido, LA
   Maróstica, MR Jr
   Pastore, GM
AF Arruda, Henrique Silvano
   Neri-Numa, Iramaia Angelica
   Kido, Larissa Akemi
   Marostica Junior, Mario Roberto
   Pastore, Glaucia Maria
TI Recent advances and possibilities for the use of plant phenolic
   compounds to manage ageing-related diseases
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Polyphenols; Neurodegenerative diseases; Metabolic syndrome; Cancer;
   Inflammation; Oxidative stress
ID BREAST-CANCER CELLS; DIETARY POLYPHENOL INTAKE; MAJOR FOOD SOURCES;
   GREEN TEA EXTRACT; Y GASTRIC BYPASS; METABOLIC SYNDROME;
   PROSTATE-CANCER; COGNITIVE FUNCTION; HUNTINGTONS-DISEASE;
   PARKINSONS-DISEASE
AB Ageing is an emerging global public health concern due to the increasing number of elderly people and ageing related degenerative disorders. Given the absence of effective treatments to manage ageing-related diseases, increasing efforts have been directed to find ways to reduce the risk of developing these disorders. Among them, plant phytochemicals, such as phenolic compounds, are considered potential anti-ageing agents due to their multifaceted biochemical actions. In this review, we focus on presenting the results of the last few years and pioneer researches mainly with animal models and human trials showing the key role of phenolic compounds as potential anti-ageing agents. Recent advances demonstrated that several phenolic compounds can reduce the risk and/or delay ageing-related disorders, including neurodegenerative diseases, metabolic syndromes, and cancers particularly by modulating signalling pathways involved in inflammation, oxidative damage, autophagy, and apoptosis. Therefore, plant phenolic compounds can be a complementary and alternative tool for managing ageing-related diseases.
C1 [Arruda, Henrique Silvano; Neri-Numa, Iramaia Angelica; Pastore, Glaucia Maria] Univ Estadual Campinas, Sch Food Engn, Dept Food Sci, Bioflavors & Bioact Cpds Lab, Monteiro Lobato St 80, BR-13083862 Campinas, SP, Brazil.
   [Arruda, Henrique Silvano; Kido, Larissa Akemi; Marostica Junior, Mario Roberto] Univ Estadual Campinas, Sch Food Engn, Dept Food & Nutr, Nutr & Metab Lab, Monteiro Lobato St 80, BR-13083862 Campinas, SP, Brazil.
   [Kido, Larissa Akemi] Univ Estadual Campinas, Inst Biol, Dept Struct & Funct Biol, Reprod Biol Lab, Bertrand Russel Ave S-N, BR-13083865 Campinas, SP, Brazil.
C3 Universidade Estadual de Campinas; Universidade Estadual de Campinas;
   Universidade Estadual de Campinas
RP Arruda, HS; Pastore, GM (corresponding author), Univ Estadual Campinas, Sch Food Engn, Monteiro Lobato St 80, BR-13083862 Campinas, SP, Brazil.
EM hsilvanoarruda@gmail.com; glaupast@unicamp.br
RI Numa, Iramaia/T-7472-2019; Kido, Larissa/J-4884-2017; Marostica,
   Mario/P-5936-2018; Arruda, Henrique/O-1846-2018
OI Arruda, Henrique/0000-0003-4963-5042
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brazil
   (CAPES) [001]; Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq) [403328/2016-0, 301496/2019-6, 406820/2018-0];
   Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [2015/50333-1, 2018/11069-5, 2015/13320-9]; CAPES
   [88887.469390/2019-00]; FAPESP [2017/01573-5]; Red Iberomericana de
   Aprovechamiento Integral de Alimentos Autoctonos Subutilizados
   (ALSUB-CYTED) [118RT0543]
FX This study was financed in part by the Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior - Brazil (CAPES, Finance Code 001), Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, grant
   numbers 403328/2016-0, 301496/2019-6 and 406820/2018-0) and Fundacao de
   Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, grant numbers
   2015/50333-1, 2018/11069-5 and 2015/13320-9). Henrique Silvano Arruda
   thanks the CAPES (grant number 88887.469390/2019-00) for his
   postdoctoral assistantship. Larrisa Akemi Kido thanks the FAPESP (grant
   number 2017/01573-5) for her postdoctoral assistantship. Mario Roberto
   Marostica Junior acknowledges Red Iberomericana de Aprovechamiento
   Integral de Alimentos Autoctonos Subutilizados (ALSUB-CYTED, 118RT0543).
CR Aboonabi A, 2020, NUTR RES, V76, P82, DOI 10.1016/j.nutres.2020.02.011
   Aboonabi A, 2019, J HUM HYPERTENS, V33, P844, DOI 10.1038/s41371-019-0273-0
   Adebiyi AO, 2016, J CARDIOVASC PHARM, V67, P136, DOI 10.1097/FJC.0000000000000325
   Adhami V. M., 2016, CRITICAL DIETARY FAC, P13, DOI [10.1007/978-3-319-21461-0_2., DOI 10.1007/978-3-319-21461-0_2]
   Adriouch S, 2018, INT J OBESITY, V42, P310, DOI 10.1038/ijo.2017.227
   Ahmad N, 2020, PHARMACEUTICS, V12, DOI 10.3390/pharmaceutics12030203
   Al Olayan EM, 2020, SCI TOTAL ENVIRON, V723, DOI 10.1016/j.scitotenv.2020.137969
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Albini A, 2016, CLIN CANCER RES, V22, P4322, DOI 10.1158/1078-0432.CCR-16-0695
   Almeida TC, 2019, ENVIRON MOL MUTAGEN, V60, P740, DOI 10.1002/em.22297
   Amini P, 2021, CURR MOL MED, V21, P142, DOI 10.2174/1566524020666200521080953
   Amiot MJ, 2016, OBES REV, V17, P573, DOI 10.1111/obr.12409
   Anastasiou CA, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0182048
   [Anonymous], 2013, Controlling the global obesity epidemic
   [Anonymous], 2019, INT J MOL SCI, DOI DOI 10.3390/ijms20184567
   [Anonymous], 2020, FOODS, DOI DOI 10.3390/foods9010055
   [Anonymous], International, DOI DOI 10.2337/dc10-S011
   Antoni S, 2017, EUR UROL, V71, P96, DOI 10.1016/j.eururo.2016.06.010
   Aparicio T., 2020, GERIATRIC ONCOLOGY, P701, DOI [10.1007/978-3-319-57415-8_35., DOI 10.1007/978-3-319-57415-8_35]
   Apovian CM, 2015, OBESITY, V23, pS1, DOI 10.1002/oby.21140
   Araghi M, 2019, INT J CANCER, V144, P2992, DOI 10.1002/ijc.32055
   Arruda HS, 2019, ULTRASON SONOCHEM, V50, P82, DOI 10.1016/j.ultsonch.2018.09.002
   Arruda HS, 2019, FOOD RES INT, V123, P450, DOI 10.1016/j.foodres.2019.05.011
   Bae HJ, 2019, NEUROCHEM INT, V131, DOI 10.1016/j.neuint.2019.104537
   Bahrami A, 2019, COMPLEMENT THER MED, V45, P269, DOI 10.1016/j.ctim.2019.04.011
   Bai Y, 2017, MOL MED REP, V15, P885, DOI 10.3892/mmr.2016.6051
   Baluchnejadmojarad T, 2017, BRAIN RES, V1662, P23, DOI 10.1016/j.brainres.2017.02.021
   Batista AG, 2018, J FUNCT FOODS, V48, P266, DOI 10.1016/j.jff.2018.07.020
   Beltrán-Sánchez H, 2013, J AM COLL CARDIOL, V62, P697, DOI 10.1016/j.jacc.2013.05.064
   Bensalem J, 2019, J GERONTOL A-BIOL, V74, P996, DOI 10.1093/gerona/gly166
   Bibi S, 2018, J NUTR, V148, P667, DOI 10.1093/jn/nxy007
   Bilir B, 2017, INT J ONCOL, V51, P223, DOI 10.3892/ijo.2017.4017
   Bolat ZB, 2020, FRONT BIOENG BIOTECH, V8, DOI 10.3389/fbioe.2020.00050
   Bolin AP, 2020, J NUTR BIOCHEM, V78, DOI 10.1016/j.jnutbio.2019.108322
   Bottazzi B, 2018, SEMIN IMMUNOL, V40, P74, DOI 10.1016/j.smim.2018.10.011
   Bumrungpert A, 2018, NUTRIENTS, V10, DOI 10.3390/nu10060713
   Calabresi P, 2006, LANCET NEUROL, V5, P974, DOI 10.1016/S1474-4422(06)70600-7
   Calabrò RS, 2019, MEDICINA-LITHUANIA, V55, DOI 10.3390/medicina55050156
   Carecho Rafael, 2021, Brain Plast, V6, P193, DOI 10.3233/BPL-200099
   Casetta I, 2005, CURR PHARM DESIGN, V11, P2033, DOI 10.2174/1381612054065729
   Castro-Barquero S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030689
   Castro-Barquero S, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101523
   Ceci C, 2016, NUTRIENTS, V8, DOI 10.3390/nu8110744
   Chait A, 2020, FRONT CARDIOVASC MED, V7, DOI 10.3389/fcvm.2020.00022
   Chandran AMK, 2019, ENVIRON TOXICOL PHAR, V71, DOI 10.1016/j.etap.2019.103224
   Chaudhary Z, 2019, FRONT BIOENG BIOTECH, V7, DOI 10.3389/fbioe.2019.00225
   Chen J, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010092
   Chen MS, 2019, J AGR FOOD CHEM, V67, P229, DOI 10.1021/acs.jafc.8b05936
   Chew B, 2019, EUR J NUTR, V58, P1223, DOI 10.1007/s00394-018-1643-z
   Chiva-Blanch G, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/5812401
   Cho YJ, 2018, J AGR FOOD CHEM, V66, P12498, DOI 10.1021/acs.jafc.8b03720
   Chung Seyung S, 2018, Oncotarget, V9, P32943, DOI 10.18632/oncotarget.25993
   Cicero AFG, 2019, PHYTOTHER RES, V33, P2094, DOI 10.1002/ptr.6402
   Colombo R, 2020, CRIT REV FOOD SCI, V60, P760, DOI 10.1080/10408398.2018.1550384
   Commins S, 2019, PHARMACOL RES, V147, DOI 10.1016/j.phrs.2019.104363
   Coppé JP, 2010, ANNU REV PATHOL-MECH, V5, P99, DOI 10.1146/annurev-pathol-121808-102144
   Crous-Masó J, 2018, MOLECULES, V23, DOI 10.3390/molecules23051160
   Cueva C, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030625
   Damiano S, 2019, J CELL PHYSIOL, V234, P23268, DOI 10.1002/jcp.28893
   de Oliveira TS, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/9842908
   Decroix L, 2019, PSYCHOPHARMACOLOGY, V236, P3421, DOI 10.1007/s00213-019-05306-z
   Dekker E, 2019, LANCET, V394, P1467, DOI 10.1016/S0140-6736(19)32319-0
   Del Bo' C, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061355
   Lima ACD, 2019, J MED FOOD, V22, P202, DOI 10.1089/jmf.2018.0080
   Della Pepa G, 2020, EUR J CLIN NUTR, V74, P183, DOI 10.1038/s41430-019-0459-0
   Dryden GW, 2013, INFLAMM BOWEL DIS, V19, P1904, DOI 10.1097/MIB.0b013e31828f5198
   Dzydzan O, 2019, FOOD FUNCT, V10, P6459, DOI [10.1039/C9FO00515C, 10.1039/c9fo00515c]
   Ellem SJ, 2010, J STEROID BIOCHEM, V118, P246, DOI 10.1016/j.jsbmb.2009.10.015
   Enkhbat T, 2018, ANTICANCER RES, V38, P6247, DOI 10.21873/anticanres.12980
   Esfandiar Z, 2020, DIABET METAB SYND OB, V13, P1643, DOI 10.2147/DMSO.S238483
   Essa MM, 2019, NEUROTOX RES, V35, P739, DOI 10.1007/s12640-018-9989-9
   Fabian CJ, 2020, CANCER PREV RES, V13, P623, DOI 10.1158/1940-6207.CAPR-20-0050
   Fan QL, 2020, J KING SAUD UNIV SCI, V32, P1959
   Farsad-Naeimi A, 2018, FOOD FUNCT, V9, P2025, DOI [10.1039/c7fo01898c, 10.1039/C7FO01898C]
   Farzaei MH, 2019, J CELL PHYSIOL, V234, P2447, DOI 10.1002/jcp.27289
   Farzaei MH, 2018, FOOD CHEM TOXICOL, V120, P183, DOI 10.1016/j.fct.2018.07.010
   Fernández J, 2018, GENES-BASEL, V9, DOI 10.3390/genes9030133
   Fidelis EM, 2019, NEUROSCIENCE, V423, P122, DOI 10.1016/j.neuroscience.2019.09.032
   Figueira I, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-11512-6
   Firdaus F, 2018, TOXICOL REP, V5, P411, DOI 10.1016/j.toxrep.2018.02.017
   Gan L, 2015, ACTA PHARMACOL SIN, V36, P597, DOI 10.1038/aps.2015.11
   García-Moreno CJ, 2019, NEUROBIOL AGING, V82, P60, DOI 10.1016/j.neurobiolaging.2019.07.003
   Gavrilas LI, 2019, FOOD FUNCT, V10, P3717, DOI [10.1039/c9fo01014a, 10.1039/C9FO01014A]
   Gee JR, 2017, CANCER PREV RES, V10, P298, DOI 10.1158/1940-6207.CAPR-16-0167
   Gentile D, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01094
   Ghosh S, 2017, NANOMED-NANOTECHNOL, V13, P2439, DOI 10.1016/j.nano.2017.08.002
   González-Sarrías A, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201800160
   Grabska-Kobylecka I, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051531
   Grodzicki W, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9030229
   Grundy SM, 2014, J CLIN LIPIDOL, V8, P29, DOI 10.1016/j.jacl.2013.12.005
   Guglielmetti S, 2020, BMC GERIATR, V20, DOI 10.1186/s12877-020-1472-9
   Gunesch S, 2020, REDOX BIOL, V29, DOI 10.1016/j.redox.2019.101378
   He JJ, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-00635-5
   He Y, 2006, J AM COLL CARDIOL, V47, P1588, DOI 10.1016/j.jacc.2005.11.074
   Henning SM, 2015, PROSTATE, V75, P550, DOI 10.1002/pros.22943
   Hithamani G, 2017, FOOD BIOSCI, V19, P101, DOI 10.1016/j.fbio.2017.06.008
   Holland TM, 2020, NEUROLOGY, V94, pE1749, DOI 10.1212/WNL.0000000000008981
   Hollands WJ, 2018, AM J CLIN NUTR, V108, P1006, DOI 10.1093/ajcn/nqy139
   Hormoznejad R, 2020, INT J FOOD SCI NUTR, V71, P991, DOI 10.1080/09637486.2020.1746957
   Hsia DS, 2020, BRIT J NUTR, V124, P577, DOI 10.1017/S0007114520001336
   Hu LF, 2020, J NUTR BIOCHEM, V77, DOI 10.1016/j.jnutbio.2019.108253
   Huang BX, 2018, J FUNCT FOODS, V45, P452, DOI 10.1016/j.jff.2018.04.018
   Ide H, 2018, CANCER SCI, V109, P1230, DOI 10.1111/cas.13517
   IDF, 2020, TYPE 2 DIABETES
   Iida K, 2020, CANCER SCI, V111, P1165, DOI 10.1111/cas.14334
   Ishida K, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020494
   Ishida K, 2020, NEUROSCI RES, V154, P35, DOI 10.1016/j.neures.2019.05.001
   Istas G, 2019, AM J CLIN NUTR, V110, P316, DOI 10.1093/ajcn/nqz075
   Miranda JJ, 2020, LANCET GLOB HEALTH, V8, pE123, DOI 10.1016/S2214-109X(19)30484-X
   Jara-Moreno D, 2018, J ALZHEIMERS DIS, V66, P1175, DOI 10.3233/JAD-180174
   Jensen JD, 2016, ACTA ONCOL, V55, P59, DOI 10.3109/0284186X.2015.1115118
   Jensen TK, 2016, ACTA ONCOL, V55, P85, DOI 10.3109/0284186X.2015.1115122
   Jiao XY, 2019, J NUTR BIOCHEM, V64, P88, DOI 10.1016/j.jnutbio.2018.07.008
   Jin DC, 2017, ONCOTARGET, V8, P97787, DOI 10.18632/oncotarget.22081
   Jin XX, 2019, CANCER MED-US, V8, P1246, DOI 10.1002/cam4.1993
   Johnson SA, 2020, J MED FOOD, V23, P1238
   Joo SH, 2019, PSYCHIAT INVEST, V16, P759, DOI 10.30773/pi.2019.06.17
   Kabala-Dzik A, 2018, CELL MOL BIOL, V64, P1, DOI 10.14715/cmb/2018.64.8.1
   Kang NJ, 2011, CARCINOGENESIS, V32, P921, DOI 10.1093/carcin/bgr022
   Kao YL, 2017, J FUNCT FOODS, V36, P1, DOI 10.1016/j.jff.2017.06.019
   Karri V, 2018, J PROTEOMICS, V187, P106, DOI 10.1016/j.jprot.2018.06.020
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kelli HM, 2015, J DIABETES METAB, V6, DOI 10.4172/2155-6156.1000513
   Khemlina G, 2015, CANCER TREAT REV, V41, P761, DOI 10.1016/j.ctrv.2015.07.001
   Khusbu FY, 2020, INT J BIOCHEM CELL B, V118, DOI 10.1016/j.biocel.2019.105644
   Kim YJ, 2019, J MED FOOD, V22, P1151, DOI 10.1089/jmf.2018.4341
   Klein S, 2004, DIABETES CARE, V27, P2067, DOI 10.2337/diacare.27.8.2067
   Ko YC, 2020, MOLECULES, V25, DOI 10.3390/molecules25112599
   Koutsos A, 2020, AM J CLIN NUTR, V111, P307, DOI 10.1093/ajcn/nqz282
   Kreilaus F, 2016, J HUNTINGTONS DIS, V5, P285, DOI 10.3233/JHD-160204
   Krikorian R, 2020, J FUNCT FOODS, V64, DOI 10.1016/j.jff.2019.103667
   Kumar G, 2019, XENOBIOTICA, V49, P339, DOI 10.1080/00498254.2018.1445882
   Kwakye GF, 2019, NEUROTOXICOLOGY, V70, P48, DOI 10.1016/j.neuro.2018.10.012
   La XQ, 2019, J AGR FOOD CHEM, V67, P2510, DOI 10.1021/acs.jafc.8b06665
   Lamas CA, 2020, FOOD FUNCT, V11, P1547, DOI [10.1039/C9FO02621E, 10.1039/c9fo02621e]
   Lamas CA, 2018, J FUNCT FOODS, V47, P434, DOI 10.1016/j.jff.2018.06.005
   Lamas CA, 2020, PROSTATE, V80, P859, DOI 10.1002/pros.24017
   Lamport DJ, 2016, AM J CLIN NUTR, V103, P775, DOI 10.3945/ajcn.115.114553
   Lazzeroni M, 2017, CANCER PREV RES, V10, P363, DOI 10.1158/1940-6207.CAPR-16-0298
   Lee B, 2020, KOREAN J PHYSIOL PHA, V24, P27, DOI 10.4196/kjpp.2020.24.1.27
   Lee DY, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9040285
   Lee ES, 2020, METABOLISM, V103, DOI 10.1016/j.metabol.2019.154015
   Lee J, 2017, EXP GERONTOL, V87, P121, DOI 10.1016/j.exger.2016.10.004
   Lee MK, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-59203-z
   Lee YH, 2019, IN VITRO CELL DEV-AN, V55, P395, DOI 10.1007/s11626-019-00363-2
   Lefèvre-Arbogast S, 2018, NEUROLOGY, V90, pE1979, DOI [10.1212/wnl.0000000000005607, 10.1212/WNL.0000000000005607]
   Leri M, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21041250
   Li J, 2018, EXP THER MED, V16, P2593, DOI 10.3892/etm.2018.6499
   Li J, 2017, BIOMED RES-INDIA, V28, P7220
   Li PC, 2019, J FUNCT FOODS, V52, P284, DOI 10.1016/j.jff.2018.11.011
   Lin R, 2020, J IMMUNOL RES, V2020, DOI 10.1155/2020/9242601
   Ling Y, 2020, EXP GERONTOL, V130, DOI 10.1016/j.exger.2019.110786
   Lins LCRF, 2018, BRAIN RES BULL, V139, P9, DOI 10.1016/j.brainresbull.2018.01.017
   Liu K, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/6713194
   Liu YL, 2020, MOL NEUROBIOL, V57, P96, DOI 10.1007/s12035-019-01759-7
   Liu ZW, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/2525967
   Lobato NS, 2012, BRAZ J MED BIOL RES, V45, P392, DOI 10.1590/S0100-879X2012007500058
   Hazas MCLD, 2018, J FUNCT FOODS, V46, P110, DOI 10.1016/j.jff.2018.04.028
   López-Otín C, 2013, CELL, V153, P1194, DOI 10.1016/j.cell.2013.05.039
   Luna-Vital D, 2020, J NUTR BIOCHEM, V79, DOI 10.1016/j.jnutbio.2020.108343
   Lund L., 2018, GERIATRIC ONCOLOGY, P1, DOI [10.1007/978-3-319-44870-1_90-1., DOI 10.1007/978-3-319-44870-1_90-1]
   Luo Ke-Wang, 2018, Oncotarget, V9, P12261, DOI 10.18632/oncotarget.24301
   Luo KW, 2017, J NUTR BIOCHEM, V41, P56, DOI 10.1016/j.jnutbio.2016.12.004
   Lv WL, 2019, J CELL PHYSIOL, V234, P23169, DOI 10.1002/jcp.28883
   Ma LY, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19092785
   Majidinia M, 2020, BIOCHEM PHARMACOL, V173, DOI 10.1016/j.bcp.2019.113688
   Márquez-Sandoval F, 2011, PUBLIC HEALTH NUTR, V14, P1702, DOI 10.1017/S1368980010003320
   Maskarinec G, 2017, NUTR CANCER, V69, P146, DOI 10.1080/01635581.2017.1250924
   Matsuo T, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0171091
   Mayo Clinic, 2020, METABOLIC SYNDROME S
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   Menze ET, 2012, NEUROTOXICOLOGY, V33, P1265, DOI 10.1016/j.neuro.2012.07.007
   Messing E, 2012, CANCER PREV RES, V5, P621, DOI 10.1158/1940-6207.CAPR-11-0455
   Mohebali N, 2018, NUTR NEUROSCI, V21, P143, DOI [10.1080/1028415X.2016.1238026, 10.1080/1028415x.2016.1238026]
   Morissette A, 2020, AM J PHYSIOL-ENDOC M, V318, pE965, DOI 10.1152/ajpendo.00560.2019
   Musolino V, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-59485-3
   Musso G, 2012, DIABETOLOGIA, V55, P885, DOI 10.1007/s00125-011-2446-4
   Nascimento-Souza MA, 2018, EUR J NUTR, V57, P617, DOI 10.1007/s00394-016-1348-0
   Nassour I, 2017, DIABETES METAB SYNDR, V10, P393, DOI 10.2147/DMSO.S142731
   Natsume M., 2018, Adv. Clin. Trans. Res., V2
   Nemes A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11091966
   Nilsson A, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0188173
   Nishimura M, 2017, FUNCT FOODS HEALTH D, V7, P353
   Nogueira-Lima E, 2020, NUTR CANCER, V72, P1366, DOI 10.1080/01635581.2019.1684526
   Nolan Paul B, 2017, Prev Med Rep, V7, P211, DOI 10.1016/j.pmedr.2017.07.004
   Ochiai R, 2019, J ALZHEIMERS DIS, V72, P1209, DOI 10.3233/JAD-190757
   Okamoto T, 2020, CLIN EXP HYPERTENS, V42, P640, DOI 10.1080/10641963.2020.1764015
   Ormazabal V, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0762-4
   Paller CJ, 2018, CLIN CANCER RES, V24, P306, DOI 10.1158/1078-0432.CCR-17-1100
   Pereira GA, 2020, FOOD CHEM, V310, DOI 10.1016/j.foodchem.2019.125857
   Perletti G, 2019, ARCH ITAL UROL ANDRO, V91, P153, DOI 10.4081/aiua.2019.3.153
   Philip P, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8120650
   Pintova S, 2019, CANCER CHEMOTH PHARM, V84, P591, DOI 10.1007/s00280-019-03886-3
   Mc Cormick BP, 2018, J CELL BIOCHEM, V119, P5402, DOI 10.1002/jcb.26693
   Qi MY, 2020, FOOD FUNCT, V11, P3706, DOI [10.1039/c9fo02398d, 10.1039/C9FO02398D]
   Qi SS, 2019, FOOD FUNCT, V10, P5350, DOI 10.1039/c9fo00681h
   Qiu W, 2017, CELL PHYSIOL BIOCHEM, V41, P1325, DOI 10.1159/000464435
   Ramesh N, 2019, 3 BIOTECH, V9, DOI 10.1007/s13205-019-1772-y
   Rawla P, 2019, WORLD J ONCOL, V10, P63, DOI 10.14740/wjon1191
   Reale G, 2018, COMPLEMENT THER MED, V39, P14, DOI 10.1016/j.ctim.2018.05.002
   Rehman SU, 2019, MOL NEUROBIOL, V56, P2774, DOI 10.1007/s12035-018-1280-9
   Ren B, 2018, FOOD FUNCT, V9, P5912, DOI [10.1039/c8fo01436a, 10.1039/C8FO01436A]
   Rivera-Franco MM, 2018, BREAST CANCER-BASIC, V12, DOI 10.1177/1178223417752677
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Rodríguez-Daza MC, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-58863-1
   Romanos-Nanclares A, 2020, J ACAD NUTR DIET, V120, P1002, DOI 10.1016/j.jand.2019.11.007
   Romao MH, 2020, J FUNCT FOODS, V65, DOI 10.1016/j.jff.2019.103726
   Rosli H, 2019, MALAYS J MED SCI, V26, P72, DOI 10.21315/mjms2019.26.3.6
   Rossi M, 2019, CANCER CAUSE CONTROL, V30, P527, DOI 10.1007/s10552-019-01158-2
   Ruderman N. B., 2016, ENDOCRINOLOGY ADULT, V1, DOI 10.1016/B978-0-323-18907-1.00043-3
   Russo GL, 2020, BIOCHEM PHARMACOL, V173, DOI 10.1016/j.bcp.2019.113719
   Saha SK, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18071544
   Saitou K, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101337
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Samavat H, 2017, CANCER PREV RES, V10, P710, DOI 10.1158/1940-6207.CAPR-17-0187
   Samson SL, 2014, ENDOCRIN METAB CLIN, V43, P1, DOI 10.1016/j.ecl.2013.09.009
   Santhakumar AB, 2018, FOOD CHEM TOXICOL, V113, P49, DOI 10.1016/j.fct.2018.01.022
   Sathya S, 2018, Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases, P239, DOI [DOI 10.1016/B978-0-12-811959-4.00015-8, 10.1016/B978-0-12-811959-4.00015-8]
   Schmid H, 2015, REV ASSOC MED BRAS, V61, P161, DOI 10.1590/1806-9282.61.02.161
   Seifaddinipour M, 2020, MOLECULES, V25, DOI 10.3390/molecules25081776
   Sereen A. K., 2017, Int J Res Pharm Sci, V10, P46, DOI 10.22159/ajpcr.2017.v10i4.12961.
   Sgarbieri Valdemiro Carlos, 2017, Braz. J. Food Technol., V20, pe2016194
   Shahidi F, 2015, J FUNCT FOODS, V18, P820, DOI 10.1016/j.jff.2015.06.018
   Sharma N, 2018, INFLAMMOPHARMACOLOGY, V26, P349, DOI 10.1007/s10787-017-0402-8
   Shin CM, 2018, CLIN NUTR, V37, P452, DOI 10.1016/j.clnu.2017.01.014
   Shishtar E, 2020, AM J CLIN NUTR, V112, P343, DOI 10.1093/ajcn/nqaa079
   Siegel R. L., 2020, CA-CANCER J CLIN, V70, P7, DOI 10.3322/caac.21590
   Sing N., 2018, J HEART STROKE, V3, P1044
   Singh S, 2016, PHARMACOLOGY, V97, P151, DOI 10.1159/000443896
   Singhal J, 2017, ONCOTARGET, V8, P75025, DOI 10.18632/oncotarget.20499
   Sinha D., 2020, ASIAN J PHARM PHARM, V6, P1, DOI [10.31024/ajpp.2020.6.1.1., DOI 10.31024/AJPP.2020.6.1.1]
   Small GW, 2018, AM J GERIAT PSYCHIAT, V26, P266, DOI 10.1016/j.jagp.2017.10.010
   Song MY, 2020, FOOD FUNCT, V11, P4940, DOI [10.1039/d0fo00616e, 10.1039/D0FO00616E]
   Stone NJ, 2005, AM J CARDIOL, V96, p53E, DOI 10.1016/j.amjcard.2005.06.006
   Suganya SN, 2017, METAB BRAIN DIS, V32, P471, DOI 10.1007/s11011-016-9929-4
   Sun F, 2016, CARCINOGENESIS, V37, P701, DOI 10.1093/carcin/bgw044
   Sun XC, 2019, ONCOL REP, V42, P425, DOI 10.3892/or.2019.7170
   Sun X, 2020, FOOD FUNCT, V11, P1334, DOI [10.1039/C9FO02131K, 10.1039/c9fo02131k]
   Sut Agnieszka, 2019, Rocz Panstw Zakl Hig, V70, P177, DOI 10.32394/rpzh.2019.0068
   Taguchi C, 2015, NUTRIENTS, V7, P10269, DOI 10.3390/nu7125530
   Tan S, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-28521-8
   Tang CH, 2020, BIOCHEM BIOPH RES CO, V526, P170, DOI 10.1016/j.bbrc.2020.03.050
   Tchernof A, 2013, PHYSIOL REV, V93, P359, DOI 10.1152/physrev.00033.2011
   Toth PP, 2010, CLIN LIPIDOL, V5, P655, DOI 10.2217/CLP.10.49
   Tune JD, 2017, TRANSL RES, V183, P57, DOI 10.1016/j.trsl.2017.01.001
   van Stee MF, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0738-4
   Victoria B, 2017, MOL CELL ENDOCRINOL, V455, P131, DOI 10.1016/j.mce.2016.12.021
   Vijg J, 2008, NATURE, V454, P1065, DOI 10.1038/nature07216
   Vitale M, 2018, EUR J NUTR, V57, P679, DOI 10.1007/s00394-016-1355-1
   Vitale M, 2017, CLIN NUTR, V36, P1686, DOI 10.1016/j.clnu.2016.11.002
   Vugic L, 2020, J FUNCT FOODS, V64, DOI 10.1016/j.jff.2019.103596
   Vuolo MM, 2019, BIOACTIVE COMPOUNDS: HEALTH BENEFITS AND POTENTIAL APPLICATIONS, P33, DOI 10.1016/B978-0-12-814774-0.00002-5
   Wagdy R, 2019, J FOOD SCI, V84, P1012, DOI 10.1111/1750-3841.14587
   Wang H, 2017, PHYSIOL BEHAV, V182, P93, DOI 10.1016/j.physbeh.2017.10.001
   Wang K, 2020, PROSTATE, V80, P977, DOI 10.1002/pros.24029
   Wang P, 2020, INT J OBESITY, V44, P213, DOI 10.1038/s41366-019-0332-1
   Wang ST, 2020, WORLD J GASTROENTERO, V26, P562, DOI 10.3748/wjg.v26.i6.562
   Wang YW, 2017, AAPS PHARMSCITECH, V18, P586, DOI 10.1208/s12249-016-0537-8
   Ward AB, 2018, WORLD J SURG ONCOL, V16, DOI 10.1186/s12957-018-1400-z
   Watanabe T, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071617
   Wightman EL, 2018, NUTRIENTS, V10, DOI 10.3390/nu10080955
   Winters S, 2017, PROG MOL BIOL TRANSL, V151, P1, DOI 10.1016/bs.pmbts.2017.07.002
   Wisnuwardani RW, 2020, EUR J NUTR, V59, P801, DOI 10.1007/s00394-019-01946-1
   Wong TY, 2017, BIOMED PHARMACOTHER, V96, P1000, DOI 10.1016/j.biopha.2017.11.131
   World Health Organization, 2018, Hearts: Technical package for cardiovascular disease management in primary health care
   World Health Organization, 2015, Ageing and health
   Xu P, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041042
   Xu ZL, 2021, EUR J CLIN NUTR, V75, P345, DOI 10.1038/s41430-020-0609-4
   Yadav E, 2019, NEUROCHEM RES, V44, P1665, DOI 10.1007/s11064-019-02792-7
   Yang CS, 2018, J FOOD DRUG ANAL, V26, P1, DOI 10.1016/j.jfda.2017.10.010
   Yang RP, 2020, J AGR FOOD CHEM, V68, P3506, DOI 10.1021/acs.jafc.0c00370
   Yang W, 2019, FOOD CHEM TOXICOL, V134, DOI 10.1016/j.fct.2019.110824
   Yang Y, 2019, CANCER MANAG RES, V11, P4631, DOI 10.2147/CMAR.S206748
   Yao QY, 2020, FRONT MED-LAUSANNE, V7, DOI 10.3389/fmed.2020.00071
   Zamora-Ros R, 2014, BRIT J CANCER, V111, P1870, DOI 10.1038/bjc.2014.459
   Zan LL, 2019, BIOENGINEERED, V10, P374, DOI 10.1080/21655979.2019.1657327
   Zhang HY, 2020, REDOX BIOL, V32, DOI 10.1016/j.redox.2020.101474
   Zhang HW, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-29308-7
   Zhang H, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0214078
   Zhang JS, 2016, NEUROSCIENCE, V325, P1, DOI 10.1016/j.neuroscience.2016.03.024
   Zhang SS, 2020, FOOD FUNCT, V11, P1425, DOI [10.1039/c9fo02288k, 10.1039/C9FO02288K]
   Zhang W, 2019, J CELL BIOCHEM, V120, P16283, DOI 10.1002/jcb.28910
   Zhang XD, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0146-2
   Zhou TT, 2018, MOL MED REP, V17, P4883, DOI 10.3892/mmr.2018.8470
   Ziauddeen N, 2019, EUR J NUTR, V58, P3183, DOI 10.1007/s00394-018-1862-3
   Zou TD, 2020, J SCI FOOD AGR, V100, P2389, DOI 10.1002/jsfa.10248
NR 287
TC 44
Z9 48
U1 2
U2 50
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD DEC
PY 2020
VL 75
AR 104203
DI 10.1016/j.jff.2020.104203
PG 35
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA PH4DG
UT WOS:000600364900004
OA gold
DA 2025-06-11
ER

PT J
AU Stone, WL
   Schetzina, K
   Stuart, C
AF Stone, William L.
   Schetzina, Karen
   Stuart, Charles
TI Childhood obesity: a systems medicine approach
SO FRONTIERS IN BIOSCIENCE-LANDMARK
LA English
DT Article
DE Pediatrics; Systems Biology; Medicine; Obesity; Genomics; Genome Wide
   Association Studies; Diabetes; Metabolic Syndrome; Proteomics;
   Metabolomics; Metagenomics; Review
ID ISLET AMYLOID POLYPEPTIDE; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; SKELETAL-MUSCLE; CARDIOVASCULAR RISK; GLUT4
   EXPRESSION; VITAMIN-E; CHILDREN; ADIPOSE
AB Childhood obesity and its sequelae are a major public health problem in both the USA and globally. This review will focus on a systems medicine approach to obesity. Systems medicine is an integrative approach utilizing the vast amount of data garnered from "omics" technology and integrating these data with conventional pathophysiology as well as diverse environmental factors such as diet, exercise, community dynamics and the intestinal microbiome. Omics technology includes genomics, epigenomics, metagenomics, metabolomics and proteomics. In addition to unraveling etiology, the goals of a systems medicine approach are to provide actionable and evidenced-based clinical approaches. In the case of childhood obesity, an additional goal is characterizing measureable risk factors/biomarkers for obesity at the earliest possible age and devising age-appropriate optimal intervention strategies. It is also important to establish the age at which interventions could be critical. As discussed below, it is possible that some of the pathophysiological and epigenetic changes resulting from childhood obesity could become more irreversible the longer the obesity remains untreated.
C1 [Stone, William L.; Schetzina, Karen] E Tennessee State Univ, James H Quillen Coll Med, Dept Pediat, Johnson City, TN 37614 USA.
   [Stuart, Charles] E Tennessee State Univ, James H Quillen Coll Med, Dept Internal Med, Johnson City, TN 37614 USA.
C3 East Tennessee State University; East Tennessee State University
RP Stone, WL (corresponding author), E Tennessee State Univ, James H Quillen Coll Med, Dept Pediat, Johnson City, TN 37614 USA.
EM stone@etsu.edu
RI Stone, William/B-6499-2008
OI Stone, William/0000-0002-6829-0417
FU National Institutes of Health [C06RR0306551]; East Tennessee State
   University Robert W. Summers Pediatric Research Endowment
FX This research was supported in part by the National Institutes of Health
   grant C06RR0306551 and the East Tennessee State University Robert W.
   Summers Pediatric Research Endowment. WLS wrote the first draft of this
   paper and both KS and CS contributed new sections and helped with the
   overall preparation of the final manuscript.
CR Abu-Farha M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0075342
   Akbar S., 2011, The British Journal of Diabetes and Vascular Disease, V11, P62
   Badman MK, 1998, CELL TISSUE RES, V291, P285, DOI 10.1007/s004410050998
   Basta Giuseppina, 2004, Recenti Progressi in Medicina, V95, P67
   Benton MC, 2015, GENOME BIOL, V16, DOI 10.1186/s13059-014-0569-x
   Bradfield JP, 2012, NAT GENET, V44, P526, DOI 10.1038/ng.2247
   Chuang JC, 2007, PEDIATR RES, V61, p24R, DOI 10.1203/pdr.0b013e3180457684
   Codoñer-Franch P, 2011, TRANSL RES, V158, P369, DOI 10.1016/j.trsl.2011.08.004
   Cox LM, 2014, CELL, V158, P705, DOI 10.1016/j.cell.2014.05.052
   Daniels SR, 2015, PEDIATRICS, V136, pE275, DOI 10.1542/peds.2015-1558
   Darmasseelane K, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0087896
   Dennis BA, 2013, CHILD OBES, V9, P15, DOI 10.1089/chi.2011.0092
   Després JP, 2012, CIRCULATION, V126, P1301, DOI 10.1161/CIRCULATIONAHA.111.067264
   Dessì A, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/981219
   Devaraj S, 2008, FREE RADICAL BIO MED, V44, P1203, DOI 10.1016/j.freeradbiomed.2007.12.018
   Drake TA, 2010, PROG MOL BIOL TRANSL, V94, P9, DOI 10.1016/S1877-1173(10)94002-7
   Esau C, 2004, J BIOL CHEM, V279, P52361, DOI 10.1074/jbc.C400438200
   Fildes A, 2015, AM J PUBLIC HEALTH, V105, pE54, DOI 10.2105/AJPH.2015.302773
   Finkelstein EA, 2014, PEDIATRICS, V133, P854, DOI 10.1542/peds.2014-0063
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Görlach A, 2015, REDOX BIOL, V6, P372, DOI 10.1016/j.redox.2015.08.016
   Goodpaster BH, 2014, DIABETES, V63, P1058, DOI 10.2337/db13-1249
   Gritz EC, 2015, FRONT PEDIATR, V3, DOI 10.3389/fped.2015.00017
   Hällström M, 2004, EUR J CLIN MICROBIOL, V23, P463, DOI 10.1007/s10096-004-1146-0
   Harrell JS, 2006, J CARDIOVASC NURS, V21, P322, DOI 10.1097/00005082-200607000-00014
   Hayward RA, 2015, NEW ENGL J MED, V372, P2197, DOI 10.1056/NEJMoa1414266
   Hilton C, 2013, INT J OBESITY, V37, P325, DOI 10.1038/ijo.2012.59
   Huang SH, 2007, CELL METAB, V5, P237, DOI 10.1016/j.cmet.2007.03.006
   Hussey SE, 2011, DIABETES OBES METAB, V13, P959, DOI 10.1111/j.1463-1326.2011.01426.x
   Institute D. G. H., 2014, LIF CHILDH OB COSTS
   Jess T, 2014, NEW ENGL J MED, V371, P2526, DOI 10.1056/NEJMcibr1409799
   Juonala M, 2011, NEW ENGL J MED, V365, P1876, DOI 10.1056/NEJMoa1010112
   Jurgens CA, 2011, AM J PATHOL, V178, P2632, DOI 10.1016/j.ajpath.2011.02.036
   Karbiener M, 2011, RNA BIOL, V8, P850, DOI 10.4161/rna.8.5.16153
   Keske MA, 2016, J PHYSIOL-LONDON, V594, P2223, DOI 10.1113/jphysiol.2014.283549
   Khatri P, 2012, PLOS COMPUT BIOL, V8, DOI 10.1371/journal.pcbi.1002375
   Klein EA, 2011, JAMA-J AM MED ASSOC, V306, P1549, DOI 10.1001/jama.2011.1437
   Koncsos P, 2010, PEDIATR RES, V67, P309, DOI 10.1203/PDR.0b013e3181c9fb66
   Kraniou GN, 2006, J APPL PHYSIOL, V101, P934, DOI 10.1152/japplphysiol.01489.2005
   Levian Candace, 2014, Yale Journal of Biology and Medicine, V87, P113
   Levisohn Paul M., 2000, Journal of Child Neurology, V15, pS22
   Li GX, 2011, MOL BIOL REP, V38, P4777, DOI 10.1007/s11033-010-0615-z
   Llewellyn CH, 2013, INT J OBESITY, V37, P1506, DOI 10.1038/ijo.2013.30
   Locke AE, 2015, NATURE, V518, P197, DOI 10.1038/nature14177
   Lu M, 2011, J BIOMED RES, V25, P266, DOI 10.1016/S1674-8301(11)60036-5
   Ludwig DS, 2001, LANCET, V357, P505, DOI 10.1016/S0140-6736(00)04041-1
   Martin ASG, 2006, AM J CLIN NUTR, V83, p461S, DOI 10.1093/ajcn/83.2.461s
   Martos-Moreno GA, 2014, INT J PEDIATR ENDOCR, DOI 10.1186/1687-9856-2014-9
   McCormack SE, 2013, PEDIATR OBES, V8, P52, DOI 10.1111/j.2047-6310.2012.00087.x
   Meier DT, 2014, DIABETOLOGIA, V57, P1884, DOI 10.1007/s00125-014-3304-y
   Meng QY, 2013, CURR CARDIOVASC RISK, V7, P73, DOI 10.1007/s12170-012-0280-y
   Montonen J, 2004, DIABETES CARE, V27, P362, DOI 10.2337/diacare.27.2.362
   Mudhasani R, 2011, J CELL PHYSIOL, V226, P1399, DOI 10.1002/jcp.22475
   Nakagawa K, 2007, J NUTR, V137, P1938, DOI 10.1093/jn/137.8.1938
   Pacifico L, 2011, NUTR METAB CARDIOVAS, V21, P455, DOI 10.1016/j.numecd.2011.01.011
   Peng YD, 2014, CELL SIGNAL, V26, P1888, DOI 10.1016/j.cellsig.2014.05.006
   Perng W, 2014, OBESITY, V22, P2570, DOI 10.1002/oby.20901
   Prentki M, 2006, J CLIN INVEST, V116, P1802, DOI 10.1172/JCI29103
   Rendo-Urteaga T, 2014, EUR J PEDIATR, V173, P609, DOI 10.1007/s00431-013-2229-7
   Robertson RP, 2004, J BIOL CHEM, V279, P42351, DOI 10.1074/jbc.R400019200
   Rönn T, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003572
   Ryder JW, 2000, DIABETES, V49, P647, DOI 10.2337/diabetes.49.4.647
   Savini I, 2013, INT J MOL SCI, V14, P10497, DOI 10.3390/ijms140510497
   Shungin D, 2015, NATURE, V518, P187, DOI 10.1038/nature14132
   Skinner A., 2013, J OBESITY, V2013, P10
   Spear BA, 2007, PEDIATRICS, V120, pS254, DOI 10.1542/peds.2007-2329F
   Stone William L, 2014, Front Biosci (Elite Ed), V6, P318
   Stone WL, 2003, AM J CLIN NUTR, V77, P899, DOI 10.1093/ajcn/77.4.899
   Striker GE, 2001, KIDNEY INT, V59, P799, DOI 10.1046/j.1523-1755.2001.059002799.x
   Uribarri J, 2015, J CLIN ENDOCR METAB, V100, P1957, DOI 10.1210/jc.2014-3925
   Vinet A, 2015, J CLIN ENDOCR METAB, V100, P442, DOI 10.1210/jc.2014-2704
   Von Korff M, 2000, WESTERN J MED, V172, P133, DOI 10.1136/ewjm.172.2.133
   Weems J, 2011, J BIOL CHEM, V286, P460, DOI 10.1074/jbc.M110.157107
   Weng-Yew W, 2011, CURR PHARM DESIGN, V17, P2206, DOI 10.2174/138161211796957445
   Westermark P, 2011, PHYSIOL REV, V91, P795, DOI 10.1152/physrev.00042.2009
   Whitlock EP, 2010, PEDIATRICS, V125, pE396, DOI 10.1542/peds.2009-1955
   Young Jeanne, 2012, Front Biosci (Schol Ed), V4, P1078
   Zraika S, 2009, DIABETOLOGIA, V52, P626, DOI 10.1007/s00125-008-1255-x
NR 78
TC 3
Z9 3
U1 0
U2 30
PU FRONTIERS IN BIOSCIENCE INC
PI IRVINE
PA 16471 SCIENTIFIC WAY, IRVINE, CA 92618 USA
SN 1093-9946
EI 1093-4715
J9 FRONT BIOSCI-LANDMRK
JI Front. Biosci.
PD JUN 1
PY 2016
VL 21
BP 1061
EP 1075
DI 10.2741/4441
PG 15
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA DK0EB
UT WOS:000374584300016
PM 27100491
DA 2025-06-11
ER

PT J
AU Balsevich, G
   Uribe, A
   Wagner, KV
   Hartmann, J
   Santarelli, S
   Labermaier, C
   Schmidt, MV
AF Balsevich, Georgia
   Uribe, Andres
   Wagner, Klaus V.
   Hartmann, Jakob
   Santarelli, Sara
   Labermaier, Christiana
   Schmidt, Mathias V.
TI Interplay between diet-induced obesity and chronic stress in mice:
   potential role of FKBP51
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
DE glucocorticoid receptor; obesity; HPA axis; gene expression
ID CHRONIC SOCIAL STRESS; PITUITARY-ADRENAL AXIS; METABOLIC SYNDROME;
   ENERGY-BALANCE; GLUCOCORTICOID-RECEPTOR; PSYCHOSOCIAL STRESS; CHILDHOOD
   TRAUMA; NEUROPEPTIDE-Y; DEFEAT STRESS; GENE
AB While it is known that stress promotes obesity, the effects of stress within an obesogenic context are not so clear and molecular targets at the interface remain elusive. The FK506-binding protein 51 (FKBP51, gene: Fkbp5) has been identified as a target gene implicated in the development of stress-related psychiatric disorders and is a possible candidate for involvement in stress and metabolic regulation. The aims of the current study are to investigate the interaction between chronic stress and an obesogenic context and to additionally examine whether FKBP51 is involved in this interaction. For this purpose, male C57BL/6 mice were exposed to a high-fat diet for 8 weeks before being challenged with chronic social defeat stress. Herein, we demonstrate that chronic stress induces hypophagia and weight loss, ultimately improving features arising from an obesogenic context, including glucose tolerance and levels of insulin and leptin. We show that Fkbp5 expression is responsive to diet and stress in the hypothalamus and hippocampus respectively. Furthermore, under basal conditions, higher levels of hypothalamic Fkbp5 expression were related to increased body weight gain. Our data indicate that Fkbp5 may represent a novel target in metabolic regulation.
C1 [Balsevich, Georgia; Uribe, Andres; Wagner, Klaus V.; Hartmann, Jakob; Santarelli, Sara; Labermaier, Christiana; Schmidt, Mathias V.] Max Planck Inst Psychiat, D-80804 Munich, Germany.
C3 Max Planck Society
RP Balsevich, G (corresponding author), Max Planck Inst Psychiat, Kraepelinstr 2-10, D-80804 Munich, Germany.
EM georgia_balsevich@mpipsykl.mpg.de
RI Santarelli, Sara/JMQ-8361-2023; Hartmann, Jakob/GPF-5919-2022
OI Balsevich, Georgia/0000-0002-7839-018X; Hartmann,
   Jakob/0000-0002-1960-8177; Schmidt, Mathias/0000-0002-3788-2268
FU European Commission Seventh Framework Program [278603]
FX This work was supported by the European Commission Seventh Framework
   Program (FP7, project number 278603).
CR Ahrén B, 2002, AM J PHYSIOL-ENDOC M, V283, pE738, DOI 10.1152/ajpendo.00199.2002
   AKANA SF, 1994, ENDOCRINOLOGY, V135, P1125, DOI 10.1210/en.135.3.1125
   BAGDADE JD, 1967, J CLIN INVEST, V46, P1549, DOI 10.1172/JCI105646
   Bartolomucci A, 2005, NEUROSCI BIOBEHAV R, V29, P67, DOI 10.1016/j.neubiorev.2004.06.009
   Bartolomucci A, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004331
   Binder EB, 2009, PSYCHONEUROENDOCRINO, V34, P99, DOI [10.1016/j.psyneuen.2008.08.018, 10.1016/j.psyneuen.2009.05.021]
   Binder EB, 2004, NAT GENET, V36, P1319, DOI 10.1038/ng1479
   Binder EB, 2008, JAMA-J AM MED ASSOC, V299, P1291, DOI 10.1001/jama.299.11.1291
   Björntorp P, 2000, NUTRITION, V16, P924, DOI 10.1016/S0899-9007(00)00422-6
   Bornstein SR, 2006, MOL PSYCHIATR, V11, P892, DOI 10.1038/sj.mp.4001873
   Chuang JC, 2010, BIOL PSYCHIAT, V67, P1075, DOI 10.1016/j.biopsych.2009.12.003
   COHEN J, 1992, PSYCHOL BULL, V112, P155, DOI 10.1037/0033-2909.112.1.155
   Collip D, 2013, BRIT J PSYCHIAT, V202, P261, DOI 10.1192/bjp.bp.112.115972
   Considine RV, 1996, NEW ENGL J MED, V334, P292, DOI 10.1056/NEJM199602013340503
   Dallman MF, 2010, TRENDS ENDOCRIN MET, V21, P159, DOI 10.1016/j.tem.2009.10.004
   Davies TH, 2005, BIOCHEMISTRY-US, V44, P2030, DOI 10.1021/bi048503v
   Davies TH, 2002, J BIOL CHEM, V277, P4597, DOI 10.1074/jbc.C100531200
   de Kloet ER, 2005, NAT REV NEUROSCI, V6, P463, DOI 10.1038/nrn1683
   Finger BC, 2011, NEUROSCIENCE, V192, P351, DOI 10.1016/j.neuroscience.2011.06.072
   Fluttert M, 2000, LAB ANIM, V34, P372, DOI 10.1258/002367700780387714
   Grün F, 2007, REV ENDOCR METAB DIS, V8, P161, DOI 10.1007/s11154-007-9049-x
   Hallschmid M, 2009, DIABETOLOGIA, V52, P2264, DOI 10.1007/s00125-009-1501-x
   Hartmann J, 2012, NEUROPHARMACOLOGY, V62, P332, DOI 10.1016/j.neuropharm.2011.07.041
   Hinney A, 2013, PROG MOL BIOL TRANSL, V114, P147, DOI 10.1016/B978-0-12-386933-3.00005-4
   Holsboer F, 2000, NEUROPSYCHOPHARMACOL, V23, P477, DOI 10.1016/S0893-133X(00)00159-7
   Ising M, 2008, EUR J NEUROSCI, V28, P389, DOI 10.1111/j.1460-9568.2008.06332.x
   Kim H, 2003, BRAIN RES, V983, P201, DOI 10.1016/S0006-8993(03)03087-7
   King BA, 2006, PHYSIOL BEHAV, V87, P221, DOI 10.1016/j.physbeh.2005.10.007
   Kivimäki M, 2006, INT J OBESITY, V30, P982, DOI 10.1038/sj.ijo.0803229
   Kuo LE, 2008, ANN NY ACAD SCI, V1148, P232, DOI 10.1196/annals.1410.035
   LEIBEL RL, 1991, AM J PHYSIOL, V260, pR785, DOI 10.1152/ajpregu.1991.260.4.R785
   Liu J, 2007, ENDOCRINOLOGY, V148, P5531, DOI 10.1210/en.2007-0745
   Liu J, 2013, INT J NEUROPSYCHOPH, V16, P105, DOI 10.1017/S146114571100174X
   McEwen BS, 2007, PHYSIOL REV, V87, P873, DOI 10.1152/physrev.00041.2006
   Michel C, 2005, HORM BEHAV, V48, P172, DOI 10.1016/j.yhbeh.2005.02.004
   Moles A, 2006, PSYCHONEUROENDOCRINO, V31, P623, DOI 10.1016/j.psyneuen.2006.01.004
   Pasquali R, 2006, ANN NY ACAD SCI, V1083, P111, DOI 10.1196/annals.1367.009
   PORSOLT RD, 1977, ARCH INT PHARMACOD T, V229, P327
   Roubos EW, 2012, GEN COMP ENDOCR, V177, P28, DOI 10.1016/j.ygcen.2012.01.009
   Roy A, 2010, NEUROPSYCHOPHARMACOL, V35, P1674, DOI 10.1038/npp.2009.236
   Sanchez ER, 2012, BBA-MOL CELL RES, V1823, P722, DOI 10.1016/j.bbamcr.2011.11.006
   Scarpace PJ, 2007, FRONT BIOSCI-LANDMRK, V12, P3531, DOI 10.2741/2332
   Scharf SH, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016883
   Schmidt MV, 2007, PSYCHONEUROENDOCRINO, V32, P417, DOI 10.1016/j.psyneuen.2007.02.011
   Seeley RJ, 2004, ANNU REV NUTR, V24, P133, DOI 10.1146/annurev.nutr.24.012003.132428
   Solomon MB, 2011, PHYSIOL BEHAV, V102, P84, DOI 10.1016/j.physbeh.2010.09.024
   SURWIT RS, 1988, DIABETES, V37, P1163, DOI 10.2337/diabetes.37.9.1163
   Tamashiro KLK, 2011, ANN NY ACAD SCI, V1231, P46, DOI 10.1111/j.1749-6632.2011.06134.x
   Touma C, 2011, BIOL PSYCHIAT, V70, P928, DOI 10.1016/j.biopsych.2011.07.023
   Ulrich-Lai YM, 2009, NAT REV NEUROSCI, V10, P397, DOI 10.1038/nrn2647
   Vermeer H, 2003, J CLIN ENDOCR METAB, V88, P277, DOI 10.1210/jc.2002-020354
   Wagner KV, 2012, NEUROPSYCHOPHARMACOL, V37, P2797, DOI 10.1038/npp.2012.150
   Wagner KV, 2011, PSYCHONEUROENDOCRINO, V36, P579, DOI 10.1016/j.psyneuen.2010.09.007
   Wang XD, 2011, NEUROBIOL DIS, V42, P300, DOI 10.1016/j.nbd.2011.01.020
   Weninger SC, 1999, REGUL PEPTIDES, V84, P69, DOI 10.1016/S0167-0115(99)00070-1
   Wochnik GM, 2005, J BIOL CHEM, V280, P4609, DOI 10.1074/jbc.M407498200
   Xie P, 2010, NEUROPSYCHOPHARMACOL, V35, P1684, DOI 10.1038/npp.2010.37
   Yach D, 2006, NAT MED, V12, P62, DOI 10.1038/nm0106-62
   Yang L, 2012, AM J PHYSIOL-ENDOC M, V302, pE987, DOI 10.1152/ajpendo.00474.2011
   Zimmermann P, 2011, AM J PSYCHIAT, V168, P1107, DOI 10.1176/appi.ajp.2011.10111577
NR 60
TC 61
Z9 63
U1 0
U2 9
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD JUL
PY 2014
VL 222
IS 1
BP 15
EP 26
DI 10.1530/JOE-14-0129
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AL6QE
UT WOS:000339256800005
PM 24781256
DA 2025-06-11
ER

PT J
AU Doulberis, M
   Kotronis, G
   Gialamprinou, D
   Kountouras, J
   Katsinelos, P
AF Doulberis, Michael
   Kotronis, Georgios
   Gialamprinou, Dimitra
   Kountouras, Jannis
   Katsinelos, Panagiotis
TI Non-alcoholic fatty liver disease: An update with special focus on the
   role of gut microbiota
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Review
DE NAFLD; Gut microbiota; Probiotics; Gastrointestinal bacteria; Metabolic
   syndrome; Obesity
ID HELICOBACTER-PYLORI INFECTION; ENDOPLASMIC-RETICULUM STRESS; IMPROVES
   INSULIN-RESISTANCE; HEPATIC STEATOSIS; WIDE ASSOCIATION;
   NATURAL-HISTORY; VITAMIN-E; INTESTINAL MICROBIOTA; URSODEOXYCHOLIC ACID;
   MOLECULAR-MECHANISMS
AB Non-alcoholic fatty liver disease (NAFLD) is a significant global health burden in children, adolescents and adults with substantial rise in prevalence over the last decades. Accumulating data from manifold studies support the idea of NAFLD as a hepatic manifestation of metabolic syndrome, being rather a systemic metabolic disease than a liver confined pathology. Emerging data support that the gut microbiome represents a significant environmental factor contributing to NAFLD development and progression. Apart from other regimens, probiotics may have a positive role in the management of NAFLD through a plethora of possible mechanisms. The current review focuses on the NAFLD multifactorial pathogenesis, including mainly the role of intestinal microbiome and all relevant issues are raised. Furthermore, the clinical manifestations and appropriate diagnostic approach of the disease are discussed, with all possible therapeutic measures that can be taken, also including the potential beneficial effect of probiotics. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Doulberis, Michael] Burgerspital Hosp, Dept Internal Med, Schongrunstr 38, CH-4500 Solothurn, Switzerland.
   [Kotronis, Georgios] Agios Paulos Hosp, Dept Internal Med, Thessaloniki 55134, Macedonia, Greece.
   [Gialamprinou, Dimitra] Aristotle Univ Thessaloniki, Papageorgiou Gen Hosp, Dept Pediat, Thessaloniki 56403, Macedonia, Greece.
   [Kountouras, Jannis; Katsinelos, Panagiotis] Aristotle Univ Thessaloniki, Med Clin 2, Dept Internal Med, Ippokrat Hosp, Thessaloniki 54642, Macedonia, Greece.
C3 Papageorgiou Hospital; Aristotle University of Thessaloniki; Aristotle
   University of Thessaloniki
RP Doulberis, M (corresponding author), Burgerspital Hosp, Dept Internal Med, Schongrunstr 38, CH-4500 Solothurn, Switzerland.
EM doulberis@gmail.com
RI Doulberis, Michael/Y-5118-2018
OI Doulberis, Michael/0000-0002-0396-5081; Kotronis,
   Georgios/0000-0003-3767-6365
CR Abdul-Hai A, 2015, WORLD J HEPATOL, V7, P1679, DOI 10.4254/wjh.v7.i12.1679
   Abu-Shanab A, 2010, NAT REV GASTRO HEPAT, V7, P691, DOI 10.1038/nrgastro.2010.172
   Ahmed A, 2015, CLIN GASTROENTEROL H, V13, P2062, DOI 10.1016/j.cgh.2015.07.029
   Ahmed M, 2015, WORLD J HEPATOL, V7, P1450, DOI 10.4254/wjh.v7.i11.1450
   Akyüz F, 2007, DIGEST DIS SCI, V52, P2359, DOI 10.1007/s10620-006-9145-x
   Al-muzafar HM, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-016-1540-z
   Alisi A, 2014, ALIMENT PHARM THER, V39, P1276, DOI 10.1111/apt.12758
   Amarapurkar Deepak N, 2004, Trop Gastroenterol, V25, P130
   Angulo P, 2007, HEPATOLOGY, V45, P846, DOI 10.1002/hep.21496
   [Anonymous], INT J MOL SCI
   [Anonymous], MICROORGANISMS
   [Anonymous], LIVER INT
   [Anonymous], METABOLISM
   [Anonymous], LIVER INT
   [Anonymous], DIG DIS SCI
   Armstrong MJ, 2014, HEPATOLOGY, V59, P1174, DOI 10.1002/hep.26717
   Armstrong MJ, 2016, LANCET, V387, P679, DOI 10.1016/S0140-6736(15)00803-X
   Athyros VG, 2017, METABOLISM, V71, P17, DOI 10.1016/j.metabol.2017.02.014
   Bäckhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Bashiardes S, 2016, MOL METAB, V5, P782, DOI 10.1016/j.molmet.2016.06.003
   Beer NL, 2009, HUM MOL GENET, V18, P4081, DOI 10.1093/hmg/ddp357
   Bhagat V, 2009, LIVER TRANSPLANT, V15, P1814, DOI 10.1002/lt.21927
   Bozaykut P, 2016, MECH AGEING DEV, V157, P17, DOI 10.1016/j.mad.2016.07.001
   Browning JD, 2004, HEPATOLOGY, V40, P1387, DOI 10.1002/hep.20466
   Byrne CD, 2015, J HEPATOL, V62, pS47, DOI 10.1016/j.jhep.2014.12.012
   Caiazzo R, 2014, ANN SURG, V260, P893, DOI 10.1097/SLA.0000000000000945
   Carabotti M, 2015, ANN GASTROENTEROL, V28, P203
   Chalasani N, 2012, HEPATOLOGY, V55, P2005, DOI 10.1002/hep.25762
   Chalasani N, 2010, GASTROENTEROLOGY, V139, P1567, DOI 10.1053/j.gastro.2010.07.057
   Charlton MR, 2011, GASTROENTEROLOGY, V141, P1249, DOI 10.1053/j.gastro.2011.06.061
   Cheung O, 2007, HEPATOLOGY, V46, P1091, DOI 10.1002/hep.21803
   Chiva M, 2002, J HEPATOL, V37, P456, DOI 10.1016/S0168-8278(02)00142-3
   Choudhury J, 2004, SEMIN LIVER DIS, V24, P349, DOI 10.1055/s-2004-860864
   Clark JM, 2002, GASTROENTEROLOGY, V122, P1649, DOI 10.1053/gast.2002.33573
   Creely SJ, 2007, AM J PHYSIOL-ENDOC M, V292, pE740, DOI 10.1152/ajpendo.00302.2006
   Dasarathy S, 2009, J HEPATOL, V51, P1061, DOI 10.1016/j.jhep.2009.09.001
   Devisscher L, 2016, J LEUKOCYTE BIOL, V99, P693, DOI 10.1189/jlb.5RU0116-016R
   Dietrich P, 2014, BEST PRACT RES CL GA, V28, P637, DOI 10.1016/j.bpg.2014.07.008
   Dongiovanni P, 2016, J NUTR BIOCHEM, V29, P1, DOI 10.1016/j.jnutbio.2015.08.024
   Dongiovanni P, 2013, WORLD J GASTROENTERO, V19, P6969, DOI 10.3748/wjg.v19.i41.6969
   Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI23621
   EASL, 2016, OBESITY FACTS, V9, P65, DOI [10.1159/000443344, 10.1007/s00125-016-3902-y, 10.1016/j.jhep.2015.11.004]
   Endo H, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0063388
   Eslamparast Tannaz, 2013, Middle East J Dig Dis, V5, P129
   Falleti E, 2011, LIVER INT, V31, P1137, DOI 10.1111/j.1478-3231.2011.02534.x
   Farrell GC, 2007, J GASTROEN HEPATOL, V22, P775, DOI 10.1111/j.1440-1746.2007.05002.x
   Fazel Y, 2016, METABOLISM, V65, P1017, DOI 10.1016/j.metabol.2016.01.012
   Félix DR, 2016, BMC PEDIATR, V16, DOI 10.1186/s12887-016-0726-3
   Franceschi F, 2015, HELICOBACTER, V20, P40, DOI 10.1111/hel.12256
   Fujita N, 2009, CANCER EPIDEM BIOMAR, V18, P424, DOI 10.1158/1055-9965.EPI-08-0725
   Furqan Saira, 2014, J Ayub Med Coll Abbottabad, V26, P46
   Gao XL, 2016, HEPATOL RES, V46, P1226, DOI 10.1111/hepr.12671
   Gao ZG, 2011, J BIOL CHEM, V286, P22227, DOI 10.1074/jbc.M111.228874
   Garg A, 2002, J CLIN ENDOCR METAB, V87, P3019, DOI 10.1210/jcem.87.7.8736
   Glen J, 2016, BMJ-BRIT MED J, V354, DOI 10.1136/bmj.i4428
   Goh GBB, 2016, DIGEST DIS SCI, V61, P1226, DOI 10.1007/s10620-016-4095-4
   Gore AC, 2015, ENDOCR REV, V36, pE1, DOI 10.1210/er.2015-1010
   Guerville M, 2016, AM J PHYSIOL-GASTR L, V311, pG1, DOI 10.1152/ajpgi.00098.2016
   Haque TR, 2016, BEST PRACT RES CL GA, V30, P133, DOI 10.1016/j.bpg.2016.02.004
   Harrison SA, 2003, AM J GASTROENTEROL, V98, P2485, DOI 10.1111/j.1572-0241.2003.08699.x
   Hasegawa T, 2001, ALIMENT PHARM THERAP, V15, P1667, DOI 10.1046/j.1365-2036.2001.01083.x
   Hashimoto E, 2013, J GASTROEN HEPATOL, V28, P64, DOI 10.1111/jgh.12271
   He SQ, 2010, J BIOL CHEM, V285, P6706, DOI 10.1074/jbc.M109.064501
   He XY, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17030300
   Hildebrandt MA, 2009, GASTROENTEROLOGY, V137, P1716, DOI 10.1053/j.gastro.2009.08.042
   Hoefert B, 1921, Zschr Klin Med, V92, P221
   Holmen OL, 2014, NAT GENET, V46, P345, DOI 10.1038/ng.2926
   Houghton D, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17040447
   Hsieh FC, 2013, NUTR METAB, V10, DOI 10.1186/1743-7075-10-35
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Iwasaki T, 2011, HEPATO-GASTROENTEROL, V58, P2103, DOI 10.5754/hge11263
   Jiang CT, 2015, J CLIN INVEST, V125, P386, DOI 10.1172/JCI76738
   Kalia HS, 2016, CLIN LIVER DIS, V20, P215, DOI 10.1016/j.cld.2015.10.005
   Kantartzis K, 2010, DIABETOLOGIA, V53, P882, DOI 10.1007/s00125-010-1663-6
   Kantartzis K, 2009, GUT, V58, P1281, DOI 10.1136/gut.2008.151977
   Kelley NS, 2016, METAB SYNDR RELAT D, V14, P417, DOI 10.1089/met.2016.0051
   Kim H, 2016, SCI REP-UK, V6, DOI 10.1038/srep37280
   Kirpich IA, 2015, CLIN BIOCHEM, V48, P923, DOI 10.1016/j.clinbiochem.2015.06.023
   Kirpich IA, 2012, ALCOHOL CLIN EXP RES, V36, P835, DOI 10.1111/j.1530-0277.2011.01673.x
   Kobyliak N, 2016, NUTR J, V15, DOI 10.1186/s12937-016-0166-9
   Kozlitina J, 2014, NAT GENET, V46, P352, DOI 10.1038/ng.2901
   Kusumoto Y, 2017, METABOLISM, V71, P1, DOI 10.1016/j.metabol.2017.02.011
   LaBrecque DR, 2014, J CLIN GASTROENTEROL, V48, P467, DOI 10.1097/MCG.0000000000000116
   Lassailly G, 2015, GASTROENTEROLOGY, V149, P379, DOI 10.1053/j.gastro.2015.04.014
   Lee J, 2017, MOL ASPECTS MED, V54, P78, DOI 10.1016/j.mam.2016.11.008
   Leuschner UFH, 2010, HEPATOLOGY, V52, P472, DOI 10.1002/hep.23727
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Lindor KD, 2004, HEPATOLOGY, V39, P770, DOI 10.1002/hep.20092
   Lonardo A, 2015, DIGEST LIVER DIS, V47, P181, DOI 10.1016/j.dld.2014.09.020
   Ma YY, 2013, WORLD J GASTROENTERO, V19, P6911, DOI 10.3748/wjg.v19.i40.6911
   Malik SM, 2009, AM J TRANSPLANT, V9, P782, DOI 10.1111/j.1600-6143.2009.02590.x
   Mancina RM, 2016, GASTROENTEROLOGY, V150, P1219, DOI 10.1053/j.gastro.2016.01.032
   Marengo A, 2016, CLIN LIVER DIS, V20, P313, DOI 10.1016/j.cld.2015.10.010
   Mehal WZ, 2013, NAT REV GASTRO HEPAT, V10, P637, DOI 10.1038/nrgastro.2013.146
   Mintziori G, 2016, EXPERT OPIN PHARMACO, V17, P1937, DOI 10.1080/14656566.2016.1225727
   Mofrad P, 2003, HEPATOLOGY, V37, P1286, DOI 10.1053/jhep.2003.50229
   Moghaddasifar I, 2016, INT J TRANSPLANT MED, V7, P149
   Mota M, 2016, METABOLISM, V65, P1049, DOI 10.1016/j.metabol.2016.02.014
   Mummadi RR, 2008, CLIN GASTROENTEROL H, V6, P1396, DOI 10.1016/j.cgh.2008.08.012
   Musso G, 2011, ANN MED, V43, P617, DOI 10.3109/07853890.2010.518623
   Nati M, 2016, REV ENDOCR METAB DIS, V17, P29, DOI 10.1007/s11154-016-9339-2
   Obika M, 2012, EXP DIABETES RES, DOI 10.1155/2012/145754
   Oh H, 2016, CLIN MOL HEPATOL, V22, P327, DOI 10.3350/cmh.2016.0049
   Okur G, 2016, NORTH CLIN ISTANB, V3, P111, DOI 10.14744/nci.2016.28199
   Pappachan JM, 2014, ENDOCRINE, V45, P344, DOI 10.1007/s12020-013-0087-8
   Park JS, 2013, PEDIATR GASTROENTERO, V16, P22, DOI 10.5223/pghn.2013.16.1.22
   Park MY, 2016, J APPL MICROBIOL, V121, P800, DOI 10.1111/jam.13158
   Paschos P, 2009, HIPPOKRATIA, V13, P9
   Petta S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0087523
   Pirazzi C, 2012, J HEPATOL, V57, P1276, DOI 10.1016/j.jhep.2012.07.030
   Polyzos SA, 2012, CURR MOL MED, V12, P68
   Polyzos SA, 2017, MINERVA ENDOCRINOL, V42, P92, DOI 10.23736/S0391-1977.16.02563-3
   Polyzos SA, 2016, METABOLISM, V65, P1062, DOI 10.1016/j.metabol.2015.11.006
   Polyzos SA, 2015, HELICOBACTER, V20, P405, DOI 10.1111/hel.12228
   Polyzos SA, 2015, METABOLISM, V64, P937, DOI 10.1016/j.metabol.2015.06.005
   Polyzos SA, 2013, BIOMARKERS, V18, P607, DOI 10.3109/1354750X.2013.838305
   Polyzos SA, 2013, METABOLISM, V62, P121, DOI 10.1016/j.metabol.2012.06.007
   Polyzos SA, 2012, J CLIN GASTROENTEROL, V46, P272, DOI 10.1097/MCG.0b013e31824587e0
   Polyzos SA, 2011, HELICOBACTER, V16, P79, DOI 10.1111/j.1523-5378.2011.00822.x
   Polyzos SA, 2009, CURR MOL MED, V9, P299, DOI 10.2174/156652409787847191
   Portillo-Sanchez P, 2015, J CLIN ENDOCR METAB, V100, P2231, DOI 10.1210/jc.2015-1966
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Rinella ME, 2015, JAMA-J AM MED ASSOC, V313, P2263, DOI 10.1001/jama.2015.5370
   Ruhanen H, 2014, J LIPID RES, V55, P739, DOI 10.1194/jlr.M046607
   Saadeh S, 2002, GASTROENTEROLOGY, V123, P745, DOI 10.1053/gast.2002.35354
   Samuel VT, 2004, J BIOL CHEM, V279, P32345, DOI 10.1074/jbc.M313478200
   Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929
   Sawas T, 2015, CLIN GASTROENTEROL H, V13, P1567, DOI 10.1016/j.cgh.2015.05.027
   Sayiner M, 2016, CLIN LIVER DIS, V20, P205, DOI 10.1016/j.cld.2015.10.001
   Schauer PR, 2014, NEW ENGL J MED, V370, P2002, DOI 10.1056/NEJMoa1401329
   Smith BK, 2016, AM J PHYSIOL-ENDOC M, V311, pE730, DOI 10.1152/ajpendo.00225.2016
   Softic S, 2016, DIGEST DIS SCI, V61, P1282, DOI 10.1007/s10620-016-4054-0
   Sookoian S, 2012, WORLD J GASTROENTERO, V18, P6018, DOI 10.3748/wjg.v18.i42.6018
   Sookoian S, 2011, HEPATOLOGY, V53, P1883, DOI 10.1002/hep.24283
   Tang A, 2015, AM J ROENTGENOL, V205, P22, DOI 10.2214/AJR.15.14552
   Than NN, 2015, ATHEROSCLEROSIS, V239, P192, DOI 10.1016/j.atherosclerosis.2015.01.001
   Ting WJ, 2015, INT J MOL SCI, V16, P25881, DOI 10.3390/ijms161025881
   Trépo E, 2014, HEPATOLOGY, V59, P2170, DOI 10.1002/hep.26767
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Usami M, 2015, WORLD J GASTROENTERO, V21, P11597, DOI 10.3748/wjg.v21.i41.11597
   Valenti L, 2007, AM J GASTROENTEROL, V102, P1251, DOI 10.1111/j.1572-0241.2007.01192.x
   Valenti L, 2014, WORLD J GASTROENTERO, V20, P3002, DOI 10.3748/wjg.v20.i11.3002
   Vrieze A, 2012, GASTROENTEROLOGY, V143, P913, DOI 10.1053/j.gastro.2012.06.031
   Wang D, 2006, ENDOCRINOLOGY, V147, P943, DOI 10.1210/en.2005-0570
   Watanabe S, 2015, J GASTROENTEROL, V50, P364, DOI 10.1007/s00535-015-1050-7
   Wei YR, 2006, AM J PHYSIOL-ENDOC M, V291, pE275, DOI 10.1152/ajpendo.00644.2005
   Woods CP, 2015, J STEROID BIOCHEM, V154, P94, DOI 10.1016/j.jsbmb.2015.07.020
   Yakaryilmaz F, 2007, INTERN MED J, V37, P229, DOI 10.1111/j.1445-5994.2006.01295.x
   Zein CO, 2011, HEPATOLOGY, V54, P1610, DOI 10.1002/hep.24544
   Zoller H, 2016, METABOLISM, V65, P1151, DOI 10.1016/j.metabol.2016.01.010
NR 150
TC 82
Z9 89
U1 2
U2 73
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUN
PY 2017
VL 71
BP 182
EP 197
DI 10.1016/j.metabol.2017.03.013
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EW5YW
UT WOS:000402583400019
PM 28521872
DA 2025-06-11
ER

PT J
AU Gundala, NKV
   Naidu, VGM
   Das, UN
AF Gundala, Naveen K. V.
   Naidu, Vegi G. M.
   Das, Undurti N.
TI Amelioration of streptozotocin-induced type 2 diabetes mellitus in
   Wistar rats by arachidonic acid
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Type 2 diabetes mellitus; Streptozotocin; Arachidonic acid; Lipoxin A4;
   Insulin; Wistar rats; Anti-oxidants; Lipocaln2; Cytokines; Glucose
ID POLYUNSATURATED FATTY-ACIDS; ALLOXAN-INDUCED CYTOTOXICITY; FACTOR-ALPHA
   BLOCKADE; METABOLIC SYNDROME-X; CELLS IN-VITRO; INSULIN-RESISTANCE;
   INFLAMMATORY CONDITION; OXIDATIVE STRESS; ASPIRIN; GLUCOSE
AB Traditionally arachidonic acid (AA, 20:4 n-6) is considered as a pro-inflammatory molecule since it forms precursor to prostaglandins (PGs), leukotrienes (LTs) and thromboxanes (TXs) that have pro inflammatory actions. Type 2 diabetes mellitus (type 2 DM) is considered as a low-grade systemic inflammatory condition in which circulating PGs and LTs are increased. Streptozotocin (STZ)-induced type 2 DM is used as a model of human type 2 DM in which peripheral insulin resistance, increased plasma interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) and hyperglycemia occurs. In the present study, we observed that oral supplementation of AA prevented STZ-induced type 2 DM in Wistar rats by restoring hyperglycemia, plasma levels of TNF-alpha and IL-6; adipose tissue NF-kappa B and lipocalin 2 (LPCLN2) and pancreatic tissue NF-kappa B and 5- and 12- lipoxygenase enzymes to normal. AA treatment enhanced insulin sensitivity and plasma lipoxin A4 (LXA4) levels, a potent anti-inflammatory molecule derived from AA. These results are supported by our previous studies wherein it was noted that plasma phospholipid content of AA and circulating LXA4 levels are low in those with type 2 DM. In a preliminary study, we also noted that high-fat-diet (HFD)-induced type 2 DM in Wistar rats can be prevented by oral supplementation of AA. These results suggest AA has anti-inflammatory and anti-diabetic actions by enhancing the production of its anti-inflammatory metabolite LXA4. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Gundala, Naveen K. V.; Das, Undurti N.] Gayatri Vidya Parishad Hosp, BioSci Res Ctr, Dept Med, GVP Coll Engn Campus, Visakhapatnam 530048, Andhra Pradesh, India.
   [Naidu, Vegi G. M.] Natl Inst Pharmaceut Educ & Res, Gauhati, India.
   [Das, Undurti N.] UND Life Sci, 2221 NW 5th St, Battle Ground, WA 98604 USA.
C3 Gayatri Vidya Parishad College of Engineering; National Institute of
   Pharmaceutical Education & Research, S.A.S. Nagar (Mohali)
RP Das, UN (corresponding author), Gayatri Vidya Parishad Hosp, BioSci Res Ctr, Dept Med, GVP Coll Engn Campus, Visakhapatnam 530048, Andhra Pradesh, India.
EM undurti@lipidworld.com
RI Das, Undurti/A-7918-2009; Gundala, Venkata Naveen/L-8395-2019
OI Naidu, VGM/0000-0003-1520-2177; Das, Undurti/0000-0002-0191-9508
CR [Anonymous], 2009, DIABETES SCI TECHNOL, DOI DOI 10.1177/193229680900300101
   Choi Sung Hee, 2013, Front Endocrinol (Lausanne), V4, P97, DOI 10.3389/fendo.2013.00097
   Dandona P, 2004, TRENDS IMMUNOL, V25, P4, DOI 10.1016/j.it.2003.10.013
   Das U.N., 2010, Metabolic syndrome pathophysiology: the role of essential fatty acids
   Das UN, 2002, EXP BIOL MED, V227, P989, DOI 10.1177/153537020222701106
   DAS UN, 1995, PROSTAG LEUKOTR ESS, V52, P387, DOI 10.1016/0952-3278(95)90066-7
   Das UN, 2017, FRONT ENDOCRINOL, V8, DOI 10.3389/fendo.2017.00182
   Das UN, 2013, PROSTAG LEUKOTR ESS, V88, P201, DOI 10.1016/j.plefa.2012.11.009
   Das UN, 2013, CLIN LIPIDOL, V8, P465, DOI 10.2217/CLP.13.32
   de Victoria EOM, 2009, DIABETES, V58, P385, DOI 10.2337/db08-0536
   Devi MMS, 2006, PROSTAG LEUKOTR ESS, V74, P39, DOI 10.1016/j.plefa.2005.09.003
   Devi MMS, 2004, PROSTAG LEUKOTR ESS, V71, P309, DOI 10.1016/j.plefa.2004.04.006
   Dominguez H, 2005, J VASC RES, V42, P517, DOI 10.1159/000088261
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   Fujita H, 2007, BIOCHEM BIOPH RES CO, V363, P37, DOI 10.1016/j.bbrc.2007.08.090
   GIUGLIANO D, 1985, J CLIN ENDOCR METAB, V61, P160, DOI 10.1210/jcem-61-1-160
   Gokulakrishnan K, 2009, MOL CELL BIOCHEM, V324, P173, DOI 10.1007/s11010-008-9996-x
   Gonzalez-Gay MA, 2006, CLIN EXP RHEUMATOL, V24, P83
   GOPAUL NK, 1995, FEBS LETT, V368, P225, DOI 10.1016/0014-5793(95)00649-T
   Govindaraj J, 2015, MOL CELL BIOCHEM, V404, P143, DOI 10.1007/s11010-015-2374-6
   Gundala NKV, 2017, NUTRITION, V35, P61, DOI 10.1016/j.nut.2016.10.004
   Hameed I, 2015, WORLD J DIABETES, V6, P598, DOI 10.4239/wjd.v6.i4.598
   Hasnain SZ, 2014, NAT MED, V20, P1417, DOI 10.1038/nm.3705
   Kaviarasan K, 2015, METABOLISM, V64, P958, DOI 10.1016/j.metabol.2015.04.005
   Keanei DC, 2011, CLIN SCI, V120, P195, DOI 10.1042/CS20100282
   Liu CY, 2017, EXP CELL RES, V352, P293, DOI 10.1016/j.yexcr.2017.02.018
   McDaniel M. L., P SOC EXP BIOL MED, V211
   Mohan IK, 2001, NUTRITION, V17, P126, DOI 10.1016/S0899-9007(00)00468-8
   Naveen KVG, 2017, BIOFACTORS, V43, P251, DOI [10.1002/biof.1336, DOI 10.1002/BIOF.1336]
   Pickup JC, 1997, DIABETOLOGIA, V40, P1286, DOI 10.1007/s001250050822
   Pickup JC, 2004, DIABETES CARE, V27, P813, DOI 10.2337/diacare.27.3.813
   Poorani R, 2016, EUR J PHARMACOL, V785, P116, DOI 10.1016/j.ejphar.2015.08.049
   REID J, 1957, BRIT MED J, V2, P1071, DOI 10.1136/bmj.2.5053.1071
   Roglic G, 2016, Global report on psoriasis
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   SMITH MJH, 1952, BIOCHEM J, V51, P18, DOI 10.1042/bj0510018
   Spite M, 2010, CIRC RES, V107, P1170, DOI 10.1161/CIRCRESAHA.110.223883
   Stanley TL, 2011, J CLIN ENDOCR METAB, V96, pE146, DOI 10.1210/jc.2010-1170
   Suresh Y, 2006, PROSTAG LEUKOTR ESS, V74, P199, DOI 10.1016/j.plefa.2005.11.006
   Suresh Y, 2003, NUTRITION, V19, P213, DOI 10.1016/S0899-9007(02)00855-9
   Suresh Y, 2003, NUTRITION, V19, P93, DOI 10.1016/S0899-9007(02)00856-0
   Suresh Y, 2001, PROSTAG LEUKOTR ESS, V64, P37, DOI 10.1054/plef.2000.0236
   Tsuruta R, 2010, BRAIN RES, V1309, P155, DOI 10.1016/j.brainres.2009.10.065
   White V, 2002, REPROD FERT DEVELOP, V14, P117, DOI 10.1071/RD01032
   Wu XD, 2005, ANTIOXID REDOX SIGN, V7, P526, DOI 10.1089/ars.2005.7.526
   Yang FJ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0108525
NR 46
TC 55
Z9 60
U1 0
U2 15
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD JAN 29
PY 2018
VL 496
IS 1
BP 105
EP 113
DI 10.1016/j.bbrc.2018.01.007
PG 9
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA FU7YF
UT WOS:000424068000018
PM 29309791
DA 2025-06-11
ER

PT J
AU Hendrie, HC
   Tu, WZ
   Tabbey, R
   Purnell, CE
   Ambuehl, RJ
   Callahan, CM
AF Hendrie, Hugh C.
   Tu, Wanzhu
   Tabbey, Rebeka
   Purnell, Christianna E.
   Ambuehl, Roberta J.
   Callahan, Christopher M.
TI Health Outcomes and Cost of Care Among Older Adults with Schizophrenia:
   A 10-Year Study Using Medical Records Across the Continuum of Care
SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Article
DE Comorbidity; mortality; dementia; cancer; nursing home; hospital care
ID NURSING-HOME ADMISSION; MENTAL-ILLNESS; METABOLIC SYNDROME;
   CANCER-MORTALITY; RELATIVE RISK; DEMENTIA; ASSOCIATION; COMORBIDITY;
   PERFORMANCE; PREVALENCE
AB Objectives: The population of older patients with schizophrenia is increasing. This study describes health outcomes, utilization, and costs over 10 years in a sample of older patients with schizophrenia compared with older patients without schizophrenia. Methods: An observational cohort study of 31,588 older adults (mean age: 70.44 years) receiving care from an urban public health system, including a community mental health center, during 1999-2008. Of these, 1,635 (5.2%) were diagnosed with schizophrenia and 757 (2.4%) had this diagnosis confirmed in the community mental health center. Patients' electronic medical records were merged with Medicare claims, Medicaid claims, the Minimum Dataset, and the Outcome and Assessment Information Set. Information on medication use was not available. Measurements: Rates of comorbid conditions, healthcare utilization, costs, and mortality. Results: Patients with schizophrenia had significantly higher rates of congestive heart failure (45.05% versus 38.84%), chronic obstructive pulmonary disease (52.71% versus 41.41%), and hypothyroidism (36.72% versus 26.73%) than the patients without schizophrenia (p < 0.001). They had significantly lower rates of cancer (30.78% versus 43.18%) and significantly higher rates of dementia (64.46% versus 32.13%). The patients with schizophrenia had significantly higher mortality risk (hazard ratio: 1.25, 95% confidence interval: 1.07-1.47) than the patients without schizophrenia. They also had significantly higher rates of healthcare utilization. The mean costs for Medicare and Medicaid were significantly higher for the patients with schizophrenia than for the patients without schizophrenia. Conclusions: The management of older adult patients with schizophrenia is creating a serious burden for our healthcare system, requiring the development of integrated models of healthcare.
C1 [Hendrie, Hugh C.; Callahan, Christopher M.] Indiana Univ Sch Med, Indianapolis, IN 46202 USA.
   [Hendrie, Hugh C.; Purnell, Christianna E.; Callahan, Christopher M.] Indiana Univ, Ctr Aging Res, Indianapolis, IN 46202 USA.
   [Hendrie, Hugh C.; Ambuehl, Roberta J.; Callahan, Christopher M.] Regenstrief Inst Inc, Indianapolis, IN USA.
   [Hendrie, Hugh C.] Indiana Univ Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA.
   [Tu, Wanzhu; Tabbey, Rebeka] Indiana Univ Sch Med, Dept Biostat, Indianapolis, IN 46202 USA.
C3 Indiana University System; Indiana University Bloomington; Indiana
   University System; Indiana University Indianapolis; Regenstrief
   Institute Inc; Indiana University System; Indiana University
   Bloomington; Indiana University System; Indiana University Bloomington
RP Hendrie, HC (corresponding author), Indiana Univ, Ctr Aging Res, 410 West 10th St,Ste 2000, Indianapolis, IN 46202 USA.
EM hhendri@iupui.edu
FU National Institutes of Health [R24 MH080827, R01 AG031222]
FX This work was supported by the National Institutes of Health (R24
   MH080827 and R01 AG031222). All authors were supported by an institution
   which received funding from these two grants.
CR Andreasen NC, 2011, BIOL PSYCHIAT, V70, P672, DOI 10.1016/j.biopsych.2011.05.017
   Andrews AO, 2009, AM J GERIAT PSYCHIAT, V17, P697, DOI 10.1097/JGP.0b013e3181aad59d
   Arnold SE, 1996, SCHIZOPHRENIA BULL, V22, P5, DOI 10.1093/schbul/22.1.5
   Aschbrenner K, 2011, J AGING SOC POLICY, V23, P286, DOI 10.1080/08959420.2011.579511
   Bartels SJ, 2004, COMMUNITY MENT HLT J, V40, P75, DOI 10.1023/B:COMH.0000015219.29172.64
   Bartels SJ, 2003, AM J GERIAT PSYCHIAT, V11, P648, DOI 10.1176/appi.ajgp.11.6.648
   Brown S, 2010, BRIT J PSYCHIAT, V196, P116, DOI 10.1192/bjp.bp.109.067512
   Callahan CM, 2012, J AM GERIATR SOC, V60, P813, DOI 10.1111/j.1532-5415.2012.03905.x
   Carney CP, 2006, J GEN INTERN MED, V21, P1133, DOI 10.1111/j.1525-1497.2006.00563.x
   Chou FHC, 2011, SCHIZOPHR RES, V129, P97, DOI 10.1016/j.schres.2011.02.018
   Chwastiak LA, 2010, PSYCHOSOM MED, V72, P817, DOI 10.1097/PSY.0b013e3181eb33e9
   Cohen CI, 2000, AM J GERIAT PSYCHIAT, V8, P19, DOI 10.1097/00019442-200002000-00003
   Colton Craig W, 2006, Prev Chronic Dis, V3, pA42
   Cuffel BJ, 1996, AM J PSYCHIAT, V153, P870
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P138
   Fullerton CA, 2009, PSYCHIAT SERV, V60, P965, DOI 10.1176/appi.ps.60.7.965
   Harvey PD, 2012, AM J GERIAT PSYCHIAT, V20, P1, DOI 10.1097/JGP.0b013e31823bbf93
   Heinrichs RW, 2005, AM PSYCHOL, V60, P229, DOI 10.1037/0003-066X.60.3.229
   Hendrie HC, 2012, AM J GERIATR PSYCHIA
   Howard RJ, 2010, AM J GERIAT PSYCHIAT, V18, P859, DOI 10.1097/JGP.0b013e3181ef78eb
   Jarskog LF, 2007, ANNU REV MED, V58, P49, DOI 10.1146/annurev.med.58.060904.084114
   Jeste DV, 1999, ARCH GEN PSYCHIAT, V56, P848, DOI 10.1001/archpsyc.56.9.848
   Keefe RSE, 2006, NEUROPSYCHOPHARMACOL, V31, P2033, DOI 10.1038/sj.npp.1301072
   Korner A, 2009, INT J GERIATR PSYCH, V24, P61, DOI 10.1002/gps.2075
   Kraemer S, 2011, BMC PSYCHIATRY, V11, DOI 10.1186/1471-244X-11-173
   Kuller LH, 2009, NEUROEPIDEMIOLOGY, V32, P70, DOI 10.1159/000170909
   Laursen TM, 2007, J CLIN PSYCHIAT, V68, P899, DOI 10.4088/JCP.v68n0612
   Loewenstein DA, 2012, AM J GERIAT PSYCHIAT, V20, P29, DOI 10.1097/JGP.0b013e31823bc08c
   Mai Q, 2011, BMC PSYCHIATRY, V11, DOI 10.1186/1471-244X-11-163
   McDonald CJ, 1999, INT J MED INFORM, V54, P225, DOI 10.1016/S1386-5056(99)00009-X
   Miller EA, 2006, MED CARE, V44, P343, DOI 10.1097/01.mlr.0000204008.83633.ed
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Osborn DPJ, 2007, ARCH GEN PSYCHIAT, V64, P242, DOI 10.1001/archpsyc.64.2.242
   Saha S, 2007, ARCH GEN PSYCHIAT, V64, P1123, DOI 10.1001/archpsyc.64.10.1123
   Savla GN, 2006, SCHIZOPHR RES, V83, P215, DOI 10.1016/j.schres.2005.12.851
   Shah JN, 2012, PSYCHIAT QUART, V83, P127, DOI 10.1007/s11126-011-9189-8
   Tabarés-Seisdedos R, 2011, LANCET ONCOL, V12, P604, DOI 10.1016/S1470-2045(11)70041-9
   Tosh G, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008298.pub2
   Tran E, 2009, CANCER-AM CANCER SOC, V115, P3555, DOI 10.1002/cncr.24383
   Weber NS, 2009, PSYCHIAT SERV, V60, P1059, DOI 10.1176/appi.ps.60.8.1059
   Zilkens RR, 2009, NEUROEPIDEMIOLOGY, V32, P61, DOI 10.1159/000170908
NR 41
TC 45
Z9 51
U1 0
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1064-7481
EI 1545-7214
J9 AM J GERIAT PSYCHIAT
JI Am. J. Geriatr. Psychiatr.
PD MAY
PY 2014
VL 22
IS 5
BP 427
EP 436
DI 10.1016/j.jagp.2012.10.025
PG 10
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA AH4HE
UT WOS:000336087200002
PM 23933423
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Tietel, Z
   Ananth, DA
   Sivasudha, T
   Klipcan, L
AF Tietel, Zipora
   Ananth, Devanesan Arul
   Sivasudha, Thilagar
   Klipcan, Liron
TI Cassia auriculata L.-A mini review of phytochemical
   compounds and their antidiabetic mechanisms
SO AIMS AGRICULTURE AND FOOD
LA English
DT Review
DE C. auriculata; avaram; medicinal properties; specialized metabolites;
   metabolic syndrome; hypoglycemic; hypolipidemic
ID TYPE-2 DIABETES-MELLITUS; MALE WISTAR RATS; HIGH-FAT-DIET; OXIDATIVE
   STRESS; D-PINITOL; D-SORBOSE; CHEMICAL-STRUCTURES; INSULIN-RESISTANCE;
   PYROGLUTAMIC ACID; FLOWER EXTRACT
AB Cassia auriculata is an important medicinal herb traditionally used for the treatment and management of diabetes. Scientific research has reported some bioactivities related to traditional roles that include antihyperglycemic and antihyperlipidemic, which could inhibit onset of diabetes. Our aim was twofold: To review the presence of phytochemical compounds in plant extracts and to perform an in-papyro evaluation of their antidiabetic potential. A detailed literature survey was carried out for evaluating metabolic syndrome -related medicinal bioactivities and antidiabetic activity from specific compounds of C. auriculata. We uncovered a wide range of medicinal uses of C. auriculata in Ayurveda and Sri Lankan medicinal traditions and cultures. Many of the compounds in C. auriculata extracts have already been reported for their specific antidiabetic, hypoglycemic, and hypolipidemic activities, which exhibited positive effects on neuro, renal, and liver support. In conclusion, our findings suggested that the phytocomposition of C. auriculata could be attributed to the presence of antidiabetic activity through various mechanisms.
C1 [Tietel, Zipora; Ananth, Devanesan Arul; Klipcan, Liron] Agr Res Org, Food Sci, Gilat Res Ctr, Volcani Inst, IL-8531100 Negev, Israel.
   [Ananth, Devanesan Arul] Amer Coll Madurai, Dept Biotechnol, Satellite Campus, Madurai, Tamil Nadu, India.
   [Sivasudha, Thilagar] Bharathidasan Univ, Dept Environm Biotechnol, Tiruchirappalli 620024, Tamil Nadu, India.
C3 VOLCANI INSTITUTE OF AGRICULTURAL RESEARCH; Bharathidasan University
RP Tietel, Z (corresponding author), Agr Res Org, Food Sci, Gilat Res Ctr, Volcani Inst, IL-8531100 Negev, Israel.
EM tietel@agri.gov.il
RI Thilagar, Sivasudha/AAZ-7386-2020; Devanesan, Arul Ananth/AAA-6237-2022
OI Thilagar, Sivasudha/0000-0001-6460-1612
CR Abd El-Aziz TA, 2012, CLIN EXP MED, V12, P233, DOI 10.1007/s10238-011-0165-2
   Abdulwaliyu I., 2019, Clinical Nutrition Experimental, V28, P42, DOI 10.1016/j.yclnex.2019.10.002
   Abesundara KJM, 2004, J AGR FOOD CHEM, V52, P2541, DOI 10.1021/jf035330s
   Addis Paul, 2012, Journal of Dietary Supplements, V9, P178, DOI 10.3109/19390211.2012.708715
   Amsalu N., 2020, Afr. J. Med. Health Sci, V19, P84, DOI [10.5897/AJMHS2019.0082, DOI 10.5897/AJMHS2019.0082]
   Anandan A., 2011, Bull Environ Pharmacol Life Sci., V1, P20
   Ananth DA, 2021, ISR J PLANT SCI, V68, P133, DOI 10.1163/22238980-bja10027
   Anitha R, 2020, IET NANOBIOTECHNOL, V14, P210, DOI 10.1049/iet-nbt.2019.0364
   Annie S, 2005, PHYTOMEDICINE, V12, P555, DOI 10.1016/j.phymed.2003.11.010
   Aye MM, 2019, MOLECULES, V24, DOI 10.3390/molecules24020293
   Badhani B, 2015, RSC ADV, V5, P27540, DOI 10.1039/c5ra01911g
   Bandawane D D., 2014, Biomedicine and Aging Pathology, V4, n, P105, DOI [DOI 10.1016/J.BIOMAG.2013.10.009, 10.1016/j.biomag.2013.10.009]
   Banerjee S, 2019, PHYTOMEDICINE, V60, DOI 10.1016/j.phymed.2019.152944
   Bargah Rohit Kumar, 2020, Research Journal of Pharmacy and Technology, V13, P2624, DOI 10.5958/0974-360X.2020.00466.7
   Bartolome AP, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/340215
   Biagi G, 2006, J ANIM SCI, V84, P370, DOI 10.2527/2006.842370x
   Chatterjee S, 2017, LANCET, V389, P2239, DOI 10.1016/S0140-6736(17)30058-2
   Chauhan PS, 2011, INT IMMUNOPHARMACOL, V11, P286, DOI 10.1016/j.intimp.2010.11.028
   Chen ZW, 2018, APPL MICROBIOL BIOT, V102, P4269, DOI 10.1007/s00253-018-8916-6
   CHING TL, 1993, CHEM-BIOL INTERACT, V86, P119, DOI 10.1016/0009-2797(93)90116-G
   Choi MS, 2009, MOL NUTR FOOD RES, V53, P751, DOI 10.1002/mnfr.200800241
   Chou J, 2018, J CHROMATOGR B, V1100, P6, DOI 10.1016/j.jchromb.2018.09.004
   Chung JY, 2017, J CANCER PREV, V22, P195
   Corrado F, 2011, DIABETIC MED, V28, P972, DOI 10.1111/j.1464-5491.2011.03284.x
   Croze ML, 2013, BIOCHIMIE, V95, P1811, DOI 10.1016/j.biochi.2013.05.011
   Dang NT, 2010, BIOSCI BIOTECH BIOCH, V74, P1062, DOI 10.1271/bbb.90963
   den Hartog GJM, 2010, NUTRITION, V26, P449, DOI 10.1016/j.nut.2009.05.004
   Deshpande S., 2013, Drug Invention Today, V5, P164, DOI [10.1016/j.dit.2013.05.006, DOI 10.1016/J.DIT.2013.05.006]
   Dludla PV, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010023
   Sousa LGF, 2020, EUR J PHARMACOL, V880, DOI 10.1016/j.ejphar.2020.173130
   Fatahi S, 2019, NUTR METAB CARDIOVAS, V29, P1168, DOI 10.1016/j.numecd.2019.07.011
   Fauzi FM, 2017, J ETHNOPHARMACOL, V197, P61, DOI 10.1016/j.jep.2016.07.058
   Flint N, 2014, ACTA DIABETOL, V51, P513, DOI 10.1007/s00592-013-0534-2
   Foster AC, 2006, CURR OPIN PHARMACOL, V6, P7, DOI 10.1016/j.coph.2005.11.005
   Gao K, 2020, ADV NUTR, V11, P709, DOI 10.1093/advances/nmz127
   Gao YF, 2015, J AGR FOOD CHEM, V63, P6019, DOI 10.1021/acs.jafc.5b01238
   Benahmed AG, 2020, APPL MICROBIOL BIOT, V104, P7225, DOI 10.1007/s00253-020-10708-7
   Gecthan PKMA, 2008, J BIOCHEM MOL TOXIC, V22, P220, DOI 10.1002/jbt.20218
   Girme A, 2019, PLANTA MED, V85, P1439, DOI 10.1055/s-0039-3399767
   Girme A, 2020, MASS SPECTROM LETT, V11, P82, DOI 10.5478/MSL.2020.11.4.82
   Grace VMB, 2022, RECENT PAT NANOTECH, V16, P160, DOI 10.2174/1872210515666210329160523
   GRIOLI S, 1990, FUND CLIN PHARMACOL, V4, P169, DOI 10.1111/j.1472-8206.1990.tb00485.x
   Gunathilake K, 2020, Asian Plant Res J, V6, P14, DOI [10.9734/APRJ/2020/v6i130118, DOI 10.9734/APRJ/2020/V6I130118]
   Gunathilake KDPP, 2018, J FOOD BIOCHEM, V42, DOI 10.1111/jfbc.12579
   Gupta S, 2009, J ETHNOPHARMACOL, V123, P499, DOI 10.1016/j.jep.2009.02.019
   Habtemariam S, 2014, CURR PHARM BIOTECHNO, V15, P391, DOI 10.2174/1389201015666140617104643
   Habtemariam S, 2013, PHYTOTHER RES, V27, P152, DOI 10.1002/ptr.4711
   Hemen Dave Hemen Dave, 2012, Indian Journal of Natural Products and Resources, V3, P291
   Hernández-Mijares A, 2013, FOOD CHEM, V141, P1267, DOI 10.1016/j.foodchem.2013.04.042
   Jancy V. Jenila Jose, 2020, Research Journal of Pharmacy and Technology, V13, P6150, DOI 10.5958/0974-360X.2020.01073.2
   Jaydeokar AV, 2014, PHARM BIOL, V52, P344, DOI 10.3109/13880209.2013.837075
   John CM, 2011, CELL IMMUNOL, V271, P474, DOI 10.1016/j.cellimm.2011.08.017
   Juan-Badaturuge M, 2011, FOOD CHEM, V125, P221, DOI 10.1016/j.foodchem.2010.08.065
   Kahkeshani N, 2019, IRAN J BASIC MED SCI, V22, P225, DOI 10.22038/ijbms.2019.32806.7897
   Karak S, 2017, REV BRAS FARMACOGN, V27, P105, DOI 10.1016/j.bjp.2016.07.007
   Khader SZA, 2017, INTEGR MED RES, V6, P131, DOI 10.1016/j.imr.2017.01.007
   Khurm M, 2021, PHYTOTHER RES, V35, P2336, DOI 10.1002/ptr.6954
   Kim E, 2019, J FUNCT FOODS, V63, DOI 10.1016/j.jff.2019.103570
   Kim HJ, 2012, ANN NUTR METAB, V60, P1, DOI 10.1159/000334834
   Kim JC, 2005, PHYTOTHER RES, V19, P1048, DOI 10.1002/ptr.1788
   Kolar FR, 2018, NAT PROD RES, V32, P1324, DOI 10.1080/14786419.2017.1342085
   Kumar JSP, 2014, AJPCT, V2, P705
   Kumar Naresh, 2019, Biotechnology Reports, V24, pe00370, DOI 10.1016/j.btre.2019.e00370
   Kumaran A, 2007, FITOTERAPIA, V78, P46, DOI 10.1016/j.fitote.2006.09.031
   Laihia J, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10050809
   Latha M, 2003, CLIN EXP PHARMACOL P, V30, P38, DOI 10.1046/j.1440-1681.2003.03785.x
   Latha M, 2003, MOL CELL BIOCHEM, V243, P23, DOI 10.1023/A:1021697311150
   Lee E, 2019, J NUTR BIOCHEM, V68, P33, DOI 10.1016/j.jnutbio.2019.03.006
   Li P, 2007, BRIT J NUTR, V98, P237, DOI 10.1017/S000711450769936X
   Li Y, 2019, J AGR FOOD CHEM, V67, P13299, DOI 10.1021/acs.jafc.9b05829
   Lingaiah Mamidala E, 2017, Amer J Sci Med Res, V3, P8
   López-Domènech S, 2018, CLIN NUTR, V37, P2036, DOI 10.1016/j.clnu.2017.09.015
   Meena V., 2019, J Pharm Phytochem, V8, P4093
   Ming XF, 2009, BMC CARDIOVASC DISOR, V9, DOI 10.1186/1471-2261-9-12
   Mizunoe Y, 2018, REDOX BIOL, V15, P115, DOI 10.1016/j.redox.2017.09.007
   Murugan P, 2021, J Popul Ther Clin Pharmacol, V28, P73, DOI [10.53555/jptcp.v28i01.2440, DOI 10.53555/JPTCP.V28I01.2440]
   Murugan T, 2013, INDIAN J PHARM SCI, V75, P122, DOI 10.4103/0250-474X.113546
   Nagarani G., 2014, FOOD SCI HUM WELL, V3, P117, DOI [10.1016/j.fshw.2014.07.001, DOI 10.1016/J.FSHW.2014.07.001]
   Nagata Y, 2018, J SCI FOOD AGR, V98, P2020, DOI 10.1002/jsfa.8687
   Nakamura S, 2014, CHEM PHARM BULL, V62, P1026, DOI 10.1248/cpb.c14-00420
   Nambirajan G, 2018, BIOMED PHARMACOTHER, V108, P1495, DOI 10.1016/j.biopha.2018.10.007
   Nguyen NK, 2015, LWT-FOOD SCI TECHNOL, V64, P1149, DOI 10.1016/j.lwt.2015.07.018
   Nille G. C., 2015, International Journal of Pharmaceutical and Biological Archives, V6, P1
   Nimalaratne C, 2011, FOOD CHEM, V129, P155, DOI 10.1016/j.foodchem.2011.04.058
   Oku T, 2014, NUTR RES, V34, P961, DOI 10.1016/j.nutres.2014.09.009
   Paranthaman Ramakrishnan Paranthaman Ramakrishnan, 2018, Pharmacognosy Journal, V10, P457, DOI 10.5530/pj.2018.3.75
   Pari L., 2002, SMJ Singapore Medical Journal, V43, P617
   Park MO, 2016, J AGR FOOD CHEM, V64, P4758, DOI 10.1021/acs.jafc.5b05849
   Pintaudi B, 2016, INT J ENDOCRINOL, V2016, DOI 10.1155/2016/9132052
   Prasathkumar M, 2021, ARAB J CHEM, V14, DOI 10.1016/j.arabjc.2021.103345
   Raj J., 2012, J. Asian. Sci., V2, P187
   Rajagopal SK, 2003, J NUTR BIOCHEM, V14, P452, DOI 10.1016/S0955-2863(03)00053-6
   Rajkumar P., 2016, International Journal of Innovative Science and Research Technology, V1, P85
   Rao GN, 2000, FITOTERAPIA, V71, P82, DOI 10.1016/S0367-326X(99)00108-2
   Roy S, 2018, J FOOD SCI, V83, P2699, DOI 10.1111/1750-3841.14358
   Saha BC, 2011, APPL MICROBIOL BIOT, V89, P879, DOI 10.1007/s00253-010-2979-3
   Sahoo J, 2020, J Pharmacogn Phytochem9, P867
   Salkovic-Petrisic M, 2014, NEUROPHARMACOLOGY, V77, P68, DOI 10.1016/j.neuropharm.2013.09.002
   Salli K, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081813
   Salma B, 2021, ACS OMEGA, V6, P492, DOI 10.1021/acsomega.0c04940
   Sathasivampillai SV, 2017, J ETHNOPHARMACOL, V198, P531, DOI 10.1016/j.jep.2016.07.053
   Seri K, 1996, METABOLISM, V45, P1368, DOI 10.1016/S0026-0495(96)90117-1
   Serra A, 2012, FOOD CHEM, V130, P383, DOI 10.1016/j.foodchem.2011.07.055
   Shafeeq RS, 2018, Res J Pharmacol Pharmacodyn, V10, P141, DOI [10.5958/2321-5836.2018.00026.5, DOI 10.5958/2321-5836.2018.00026.5]
   Shanmugam H, 2022, Int J Health Sci, V6, P5617, DOI [10.53730/ijhs.v6nS3.7190, DOI 10.53730/IJHS.V6NS3.7190]
   Sharmila G, 2016, IND CROP PROD, V84, P13, DOI 10.1016/j.indcrop.2016.01.010
   Sivakumar S, 2010, FREE RADICAL RES, V44, P668, DOI 10.3109/10715761003733901
   Sivakumar V, 2014, CHEM ENG RES DES, V92, P1827, DOI 10.1016/j.cherd.2014.04.007
   Su H, 2018, EUR J NUTR, V57, P877, DOI 10.1007/s00394-017-1386-2
   Surman C, 2021, J DIET SUPPL, V18, P119, DOI 10.1080/19390211.2020.1731044
   Sutar S, 2023, J RES PHARM, V27, P1402, DOI 10.29228/jrp.427
   SUZUKI M, 1983, J NUTR SCI VITAMINOL, V29, P553, DOI 10.3177/jnsv.29.553
   Thompson J, 2014, J CLIN PHARMACOL, V54, P546, DOI 10.1002/jcph.241
   Tietel Z, 2021, OMICS, V25, P294, DOI 10.1089/omi.2021.0010
   Umeno A, 2016, MOLECULES, V21, DOI 10.3390/molecules21060708
   Unfer V, 2017, ENDOCR CONNECT, V6, P647, DOI 10.1530/EC-17-0243
   Ur-Rehman S, 2015, CRIT REV FOOD SCI, V55, P1514, DOI 10.1080/10408398.2012.702288
   VARSHNEY SC, 1973, PLANTA MED, V23, P363, DOI 10.1055/s-0028-1099456
   Vasaikar N, 2018, CHEM-BIOL INTERACT, V290, P6, DOI 10.1016/j.cbi.2018.05.003
   Vijayakumar R, 2017, BIOMED PHARMACOTHER, V95, P394, DOI 10.1016/j.biopha.2017.08.075
   Vijayaraj P, 2013, EXP TOXICOL PATHOL, V65, P135, DOI 10.1016/j.etp.2011.07.001
   Vinayagam R, 2016, PHYTOTHER RES, V30, P184, DOI 10.1002/ptr.5528
   Vogt JA, 2006, J NUTR, V136, P2160, DOI 10.1093/jn/136.8.2160
   Wakuda T, 2013, J FUNCT FOODS, V5, P516, DOI 10.1016/j.jff.2012.10.010
   Wasana KGP, 2022, EUR J INTEGR MED, V55, DOI 10.1016/j.eujim.2022.102177
   Wen HX, 2018, J AGR FOOD CHEM, V66, P1401, DOI 10.1021/acs.jafc.7b05033
   Wölnerhanssen BK, 2020, CRIT REV FOOD SCI, V60, P1986, DOI 10.1080/10408398.2019.1623757
   Yamada T, 2014, J NUTR SCI VITAMINOL, V60, P297, DOI 10.3177/jnsv.60.297
   Yoshida Y, 2003, J NUTR SCI VITAMINOL, V49, P277, DOI 10.3177/jnsv.49.277
   Yoshinari O, 2011, BRIT J NUTR, V106, P995, DOI 10.1017/S0007114511001279
   Yue H, 2021, CRIT REV FOOD SCI, V61, P2894, DOI 10.1080/10408398.2020.1790496
   Zhang Y, 2015, TETRAHEDRON, V71, P6727, DOI 10.1016/j.tet.2015.07.045
NR 132
TC 0
Z9 1
U1 2
U2 4
PU AMER INST MATHEMATICAL SCIENCES-AIMS
PI SPRINGFIELD
PA PO BOX 2604, SPRINGFIELD, MO 65801-2604, UNITED STATES
SN 2471-2086
J9 AIMS AGRIC FOOD
JI AIMS AGRIC. FOOD
PY 2024
VL 9
IS 1
BP 374
EP 392
DI 10.3934/agrfood.2024022
PG 19
WC Agriculture, Multidisciplinary; Agronomy; Food Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Agriculture; Food Science & Technology
GA MX2H4
UT WOS:001196864600001
OA gold
DA 2025-06-11
ER

PT J
AU Rizvi, AA
AF Rizvi, Ali A.
TI Hypertension, Obesity, and Inflammation: The Complex Designs of a Deadly
   Trio
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Review
ID C-REACTIVE PROTEIN; ANGIOTENSIN-CONVERTING-ENZYME; VASCULAR
   SMOOTH-MUSCLE; FACTOR-KAPPA-B; ENDOTHELIAL GROWTH-FACTOR; TYPE-1
   RECEPTOR BLOCKADE; II INDUCES INTERLEUKIN-6; CORONARY-HEART-DISEASE;
   CHRONIC KIDNEY-DISEASE; NECROSIS-FACTOR-ALPHA
AB Hypertension is a powerful risk factor for cardiovascular disease and frequently occurs in conjunction with obesity and the metabolic syndrome. Recent research into the underlying pathophysiologic processes common to these entities has uncovered the role of a heightened inflammatory state signified by a host of circulating biocytokines. Systemic and local hormonal effectors, such as angiotensin II and aldosterone, interact with inflammatory and oxidative stress to augment endothelial damage in a complex manner. The kidneys play a prominent role in the renin-angiotensin cascade and the abnormal pressor response that ensues. Insulin resistance underlies the pathogenesis of obesity and the metabolic syndrome. The interplay of hypertension, insulin resistance, and obesity vastly enhances the noxious influence of inflammation on the vasculature, promoting deleterious immune adaptations and ultimately increasing atherosclerotic risk. Although certain classes of available pharmacologic agents already address the altered endovascular and humoral dynamics in hypertension, a better understanding of the proinflammatory picture holds promise of targeted treatment modalities in future.
C1 [Rizvi, Ali A.] Univ S Carolina, Sch Med, Dept Med, Univ Diabet & Endocrinol Ctr, Columbia, SC 29208 USA.
C3 University of South Carolina System; University of South Carolina
   Columbia
RP Rizvi, AA (corresponding author), 2 Med Pk,Suite 502, Columbia, SC 29203 USA.
EM ali.rizvi@uscmed.sc.edu
RI Rizvi, Ali/AFV-2240-2022
CR Alexander BT, 2002, AM J HYPERTENS, V15, P170, DOI 10.1016/S0895-7061(01)02255-5
   Andersen K, 2008, HORM METAB RES, V40, P635, DOI 10.1055/s-0028-1083810
   Baumgartner I, 2001, ANNU REV PHYSIOL, V63, P427, DOI 10.1146/annurev.physiol.63.1.427
   Bautista LE, 2001, J HYPERTENS, V19, P857, DOI 10.1097/00004872-200105000-00004
   Bravo PE, 2006, VASC HEALTH RISK MAN, V2, P163, DOI 10.2147/vhrm.2006.2.2.163
   Brown NJ, 2008, HYPERTENSION, V51, P161, DOI 10.1161/HYPERTENSIONAHA.107.095489
   Capers Q, 1997, HYPERTENSION, V30, P1397, DOI 10.1161/01.HYP.30.6.1397
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Cheng ZJ, 2005, MED SCI MONITOR, V11, pRA194
   Chrysohoou C, 2004, AM J HYPERTENS, V17, P568, DOI 10.1016/j.amjhyper.2004.03.675
   Dahlöf B, 2002, LANCET, V359, P995, DOI 10.1016/S0140-6736(02)08089-3
   Danesh J, 2004, NEW ENGL J MED, V350, P1387, DOI 10.1056/NEJMoa032804
   Daugherty A, 2002, CIRC RES, V90, P1039, DOI 10.1161/01.RES.0000021397.28936.F9
   Dauphinot V, 2009, J HYPERTENS, V27, P736, DOI 10.1097/HJH.0b013e328326f801
   de Gasparo M, 2000, PHARMACOL REV, V52, P415
   Del Fiorentino A, 2009, VASC HEALTH RISK MAN, V5, P233
   Dernellis J, 2005, HYPERTENSION, V45, P426, DOI 10.1161/01.HYP.0000157818.58878.93
   Elliott P, 2009, JAMA-J AM MED ASSOC, V302, P37, DOI 10.1001/jama.2009.954
   Engström G, 2002, STROKE, V33, P2744, DOI 10.1161/01.STR.0000034787.02925.1F
   Ferrario C, 2009, VASC HEALTH RISK MAN, V5, P301
   Friederich M, 2009, CURR DIABETES REV, V5, P120, DOI 10.2174/157339909788166800
   GRIENDLING KK, 1994, CIRC RES, V74, P1141, DOI 10.1161/01.RES.74.6.1141
   Grossman E, 2008, DIABETES CARE, V31, pS185, DOI 10.2337/dc08-s246
   Grundy SM, 2003, JAMA-J AM MED ASSOC, V290, P3000, DOI 10.1001/jama.290.22.3000
   Guzik TJ, 2006, J PHYSIOL PHARMACOL, V57, P505
   Guzik TJ, 2007, CIRC RES, V101, P227, DOI 10.1161/CIRCRESAHA.107.158295
   Hackam DG, 2003, JAMA-J AM MED ASSOC, V290, P932, DOI 10.1001/jama.290.7.932
   Han YQ, 1999, CIRC RES, V84, P695, DOI 10.1161/01.RES.84.6.695
   Hansson GK, 2002, CIRC RES, V91, P281, DOI 10.1161/01.RES.0000029784.15893.10
   Harrison DG, 2009, MED CLIN N AM, V93, P621, DOI 10.1016/j.mcna.2009.02.015
   Hermann DM, 2009, J CEREBR BLOOD F MET, V29, P1620, DOI 10.1038/jcbfm.2009.100
   Hwu CM, 2009, QJM-INT J MED, V102, P705, DOI 10.1093/qjmed/hcp107
   Iannitti T, 2009, EUR REV MED PHARMACO, V13, P245
   Ishii H, 2008, INTERNAL MED, V47, P2013, DOI 10.2169/internalmedicine.47.1162
   Jialal I, 2004, HYPERTENSION, V44, P6, DOI 10.1161/01.HYP.0000130484.20501.df
   KAPLAN NM, 1989, ARCH INTERN MED, V149, P1514, DOI 10.1001/archinte.149.7.1514
   LaMarca BBD, 2005, HYPERTENSION, V46, P1022, DOI 10.1161/01.HYP.0000175476.26719.36
   Landmesser U, 2004, CIRCULATION, V109, P27, DOI 10.1161/01.CIR.0000129501.88485.1f
   Lemarié CA, 2003, CIRC RES, V93, P207, DOI 10.1161/01.RES.0000086942.13523.88
   Li J, 2005, FASEB J, V19, P617, DOI 10.1096/fj.04-2960fje
   Li J, 2007, NEPHROL DIAL TRANSPL, V22, P3107, DOI 10.1093/ndt/gfm469
   Liao TD, 2008, HYPERTENSION, V52, P256, DOI 10.1161/HYPERTENSIONAHA.108.112706
   Libby P, 2002, NATURE, V420, P868, DOI 10.1161/ATVBAHA.108.179705
   Lim HS, 2005, AM J HYPERTENS, V18, P1017, DOI 10.1016/j.amjhyper.2005.03.742
   Lucius R, 1998, J EXP MED, V188, P661, DOI 10.1084/jem.188.4.661
   Luther JM, 2006, HYPERTENSION, V48, P1050, DOI 10.1161/01.HYP.0000248135.97380.76
   Luvarà G, 1998, ARTERIOSCL THROM VAS, V18, P1408, DOI 10.1161/01.ATV.18.9.1408
   Mallat Z, 1999, CIRC RES, V85, pE17, DOI 10.1161/01.RES.85.8.e17
   Mallat Z, 2003, CIRCULATION, V108, P1232, DOI 10.1161/01.CIR.0000089083.61317.A1
   MANICARDI V, 1986, J CLIN ENDOCR METAB, V62, P1302, DOI 10.1210/jcem-62-6-1302
   Manning RD, 2005, AM J NEPHROL, V25, P311, DOI 10.1159/000086411
   Manrique C, 2009, MED CLIN N AM, V93, P569, DOI 10.1016/j.mcna.2009.02.014
   Mathieu P, 2009, HYPERTENSION, V53, P577, DOI 10.1161/HYPERTENSIONAHA.108.110320
   Mazzolai L, 2004, HYPERTENSION, V44, P277, DOI 10.1161/01.HYP.0000140269.55873.7b
   MBANYA JCN, 1988, LANCET, V1, P733
   Meyer G, 1996, CIRC RES, V79, P532, DOI 10.1161/01.RES.79.3.532
   Mikhail N, 2009, CURR HYPERTENS REP, V11, P156, DOI 10.1007/s11906-009-0027-4
   MULLER DC, 1993, J CLIN ENDOCR METAB, V76, P544, DOI 10.1210/jc.76.3.544
   Negro R, 2008, VASC HEALTH RISK MAN, V4, P89, DOI 10.2147/vhrm.2008.04.01.89
   Niskanen L, 2004, HYPERTENSION, V44, P859, DOI 10.1161/01.HYP.0000146691.51307.84
   Paravicini TM, 2008, DIABETES CARE, V31, pS170, DOI 10.2337/dc08-s247
   Pedrinelli R, 2004, ARTERIOSCL THROM VAS, V24, P2414, DOI 10.1161/01.ATV.0000147415.40692.7f
   Potter DD, 1998, CIRCULATION, V98, P800, DOI 10.1161/01.CIR.98.8.800
   Rajagopalan S, 1996, J CLIN INVEST, V97, P1916, DOI 10.1172/JCI118623
   Reaven GM, 2003, J CLIN ENDOCR METAB, V88, P2399, DOI 10.1210/jc.2003-030087
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Rodríguez- Iturbe B, 2005, J PHARMACOL EXP THER, V315, P51, DOI 10.1124/jpet.105.088062
   Rozman B, 2007, DRUG DELIV, V14, P235, DOI 10.1080/10717540601067786
   Saad MF, 2004, HYPERTENSION, V43, P1324, DOI 10.1161/01.HYP.0000128019.19363.f9
   Sandhofer A, 2009, ATHEROSCLEROSIS, V206, P265, DOI 10.1016/j.atherosclerosis.2009.01.031
   Schieffer B, 2004, J AM COLL CARDIOL, V44, P362, DOI 10.1016/j.jacc.2004.03.065
   SCHIEFFER B, 1994, CIRCULATION, V89, P2273, DOI 10.1161/01.CIR.89.5.2273
   Schillaci G, 2003, J HYPERTENS, V21, P1841, DOI 10.1097/00004872-200310000-00010
   Schunkert H, 2008, NEW ENGL J MED, V359, P1953, DOI 10.1056/NEJMe0807235
   Schupp M, 2004, CIRCULATION, V109, P2054, DOI 10.1161/01.CIR.0000127955.36250.65
   Sesso HD, 2003, JAMA-J AM MED ASSOC, V290, P2945, DOI 10.1001/jama.290.22.2945
   Shao J, 2003, HYPERTENSION, V42, P31, DOI 10.1161/01.HYP.0000075082.06183.4E
   Sironi L, 2004, J PHARMACOL EXP THER, V311, P989, DOI 10.1124/jpet.104.072066
   Smith GD, 2005, ARTERIOSCL THROM VAS, V25, P1051, DOI 10.1161/01.ATV.0000160351.95181.d0
   Srinivasan SR, 2006, HYPERTENSION, V48, P33, DOI 10.1161/01.HYP.0000226410.11198.f4
   Stumpf C, 2005, J HYPERTENS, V23, P995, DOI 10.1097/01.hjh.0000166840.63312.12
   Tedgui A, 2004, HYPERTENSION, V44, P257, DOI 10.1161/01.HYP.0000140270.26523.9b
   Unger T, 1999, AM J CARDIOL, V84, p9S
   Vaziri Nosratola D, 2008, Iran J Kidney Dis, V2, P1
   Verma S, 2003, AM J PHYSIOL-REG I, V285, pR1253, DOI 10.1152/ajpregu.00170.2003
   Verma S, 2009, CAN J CARDIOL, V25, pE236, DOI 10.1016/S0828-282X(09)70508-2
   Virdis A, 2003, CURR OPIN NEPHROL HY, V12, P181, DOI 10.1097/00041552-200303000-00009
   Wada H, 2010, ATHEROSCLEROSIS, V208, P512, DOI 10.1016/j.atherosclerosis.2009.07.045
   Wahba IM, 2007, CLIN J AM SOC NEPHRO, V2, P550, DOI 10.2215/CJN.04071206
   Wang CH, 2003, CIRCULATION, V107, P1783, DOI 10.1161/01.CIR.0000061916.95736.E5
   Wang H, 2004, J HYPERTENS, V22, P1323, DOI 10.1097/01.hjh.0000125437.28861.40
   Wang ZV, 2008, HYPERTENSION, V51, P8, DOI 10.1161/HYPERTENSIONAHA.107.099424
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Wellen KE, 2003, J CLIN INVEST, V112, P1785, DOI 10.1172/JCI20514
   Wheatcroft SB, 2003, DIABETIC MED, V20, P255, DOI 10.1046/j.1464-5491.2003.00869.x
   Willerson JT, 2004, CIRCULATION, V109, P2, DOI 10.1161/01.CIR.0000129535.04194.38
   Wu L, 2001, CIRCULATION, V104, P2716, DOI 10.1161/hc4601.099404
   YAMADA H, 1991, CIRC RES, V68, P141, DOI 10.1161/01.RES.68.1.141
   Yan JC, 2005, CLIN CHIM ACTA, V355, P191, DOI 10.1016/j.cccn.2005.01.009
   Yusuf S, 2000, NEW ENGL J MED, V342, P145
   Zacho J, 2008, NEW ENGL J MED, V359, P1897, DOI 10.1056/NEJMoa0707402
   Zhao QW, 2004, HYPERTENSION, V44, P264, DOI 10.1161/01.HYP.0000138688.78906.6b
NR 103
TC 29
Z9 31
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD AUG
PY 2010
VL 8
IS 4
BP 287
EP 294
DI 10.1089/met.2009.0116
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 637GA
UT WOS:000280803500001
PM 20367224
DA 2025-06-11
ER

PT J
AU Jahng, JWS
   Alsaadi, RM
   Palanivel, R
   Song, EF
   Hipolito, VEB
   Sung, HK
   Botelho, RJ
   Russell, RC
   Sweeney, G
AF Jahng, James Won Suk
   Alsaadi, Reham Musaibeh
   Palanivel, Rengasamy
   Song, Erfei
   Hipolito, Victoria Emily Barbosa
   Sung, Hye Kyoung
   Botelho, Roberto Jorge
   Russell, Ryan Charles
   Sweeney, Gary
TI Iron overload inhibits late stage autophagic flux leading to insulin
   resistance
SO EMBO REPORTS
LA English
DT Article
DE ALR; autophagy; insulin resistance; iron overload; mTORC1
ID OXIDATIVE STRESS; MAMMALIAN TARGET; CARDIOMYOCYTE APOPTOSIS; SECRETORY
   CAPACITY; REGULATE AUTOPHAGY; RAPAMYCIN MTOR; CELLS; ADIPONECTIN;
   SENSITIVITY; HOMEOSTASIS
AB Iron overload, a common clinical occurrence, is implicated in the metabolic syndrome although the contributing pathophysiological mechanisms are not fully defined. We show that prolonged iron overload results in an autophagy defect associated with accumulation of dysfunctional autolysosomes and loss of free lysosomes in skeletal muscle. These autophagy defects contribute to impaired insulin-stimulated glucose uptake and insulin signaling. Mechanistically, we show that iron overload leads to a decrease in Akt-mediated repression of tuberous sclerosis complex (TSC2) and Rheb-mediated mTORC1 activation on autolysosomes, thereby inhibiting autophagic-lysosome regeneration. Constitutive activation of mTORC1 or iron withdrawal replenishes lysosomal pools via increased mTORC1-UVRAG signaling, which restores insulin sensitivity. Induction of iron overload via intravenous iron-dextran delivery in mice also results in insulin resistance accompanied by abnormal autophagosome accumulation, lysosomal loss, and decreased mTORC1-UVRAG signaling in muscle. Collectively, our results show that chronic iron overload leads to a profound autophagy defect through mTORC1-UVRAG inhibition and provides new mechanistic insight into metabolic syndrome-associated insulin resistance.
C1 [Jahng, James Won Suk; Palanivel, Rengasamy; Song, Erfei; Sung, Hye Kyoung; Sweeney, Gary] York Univ, Dept Biol, Toronto, ON, Canada.
   [Alsaadi, Reham Musaibeh; Russell, Ryan Charles] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON, Canada.
   [Hipolito, Victoria Emily Barbosa; Botelho, Roberto Jorge] Ryerson Univ, Dept Chem & Biol, Toronto, ON, Canada.
   [Hipolito, Victoria Emily Barbosa; Botelho, Roberto Jorge] Ryerson Univ, Mol Sci Grad Program, Toronto, ON, Canada.
C3 York University - Canada; University of Ottawa; Toronto Metropolitan
   University; Toronto Metropolitan University
RP Sweeney, G (corresponding author), York Univ, Dept Biol, Toronto, ON, Canada.; Russell, RC (corresponding author), Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON, Canada.
EM ryan.russell@uottawa.ca; gsweeney@yorku.ca
RI Alsaadi, Reham/AAS-6821-2021; RENGASAMY, PALANIVEL/GMW-4099-2022;
   Botelho, Roberto/B-9145-2013
OI Botelho, Roberto/0000-0002-7820-0999; Alsaadi,
   Reham/0000-0003-0136-8803; Russell, Ryan/0000-0003-3364-8869; Jahng, Won
   Suk/0000-0003-2367-6567
FU Canadian Institutes of Health Research (CIHR); Heart & Stroke Foundation
   of Ontario; CIHR [PJT153034]; CIHR Frederick Banting and Charles Best
   Canada Graduate Scholarship
FX GS acknowledges support from Canadian Institutes of Health Research
   (CIHR) and a Career Investigator Award from Heart & Stroke Foundation of
   Ontario. RCR also acknowledges support from CIHR (#PJT153034). JWSJ is a
   recipient of CIHR Frederick Banting and Charles Best Canada Graduate
   Scholarship. We greatly appreciate Dr.s' James R Connor and Stephanie
   Patton, Penn State Hershey Medical Center for providing IRE-CFP reporter
   and Dr Christopher J. Chang, University of California Berkeley for
   providing IP-1 probe.
CR Abraham D, 2006, DIABETOLOGIA, V49, P2546, DOI 10.1007/s00125-006-0445-7
   Ahlstrom P, 2017, J MOL ENDOCRINOL, V59, P339, DOI 10.1530/JME-17-0096
   Aron AT, 2018, CURR OPIN CHEM BIOL, V43, P113, DOI 10.1016/j.cbpa.2017.12.010
   Au-Yeung HY, 2013, J AM CHEM SOC, V135, P15165, DOI 10.1021/ja4072964
   BOFILL C, 1994, METABOLISM, V43, P614, DOI 10.1016/0026-0495(94)90204-6
   Brissot P, 2012, BBA-GEN SUBJECTS, V1820, P403, DOI 10.1016/j.bbagen.2011.07.014
   Cen WJ, 2018, J CELL PHYSIOL, V233, P6779, DOI 10.1002/jcp.26405
   Chen G, 2013, AM J MED SCI, V345, P369, DOI 10.1097/MAJ.0b013e318271c031
   Chen W, 2011, BLOOD, V117, P6319, DOI 10.1182/blood-2010-12-327957
   Chen Y, 2018, MOL CELLS, V41, P45, DOI 10.14348/molcells.2018.2265
   Chiang GG, 2005, J BIOL CHEM, V280, P25485, DOI 10.1074/jbc.M501707200
   Cooksey RC, 2004, ENDOCRINOLOGY, V145, P5305, DOI 10.1210/en.2004-0392
   Cooksey RC, 2010, AM J PHYSIOL-ENDOC M, V298, pE1236, DOI 10.1152/ajpendo.00022.2010
   Datz C, 2013, EUR J CLIN INVEST, V43, P215, DOI 10.1111/eci.12032
   Egan DF, 2011, AUTOPHAGY, V7, P645, DOI 10.4161/auto.7.6.15123
   Espósito BP, 2002, ANAL BIOCHEM, V304, P1, DOI 10.1006/abio.2002.5611
   Evstatiev R, 2012, GUT, V61, P933, DOI 10.1136/gut.2010.214312
   Fernández-Real JM, 2002, DIABETES, V51, P1000, DOI 10.2337/diabetes.51.4.1000
   Fernández-Real JM, 2002, DIABETES, V51, P2348, DOI 10.2337/diabetes.51.8.2348
   Gabrielsen JS, 2012, J CLIN INVEST, V122, P3529, DOI 10.1172/JCI44421
   Galaris D, 2008, CRIT REV CL LAB SCI, V45, P1, DOI 10.1080/10408360701713104 
   Ganley IG, 2009, J BIOL CHEM, V284, P12297, DOI 10.1074/jbc.M900573200
   Hara T, 2008, J CELL BIOL, V181, P497, DOI 10.1083/jcb.200712064
   Heming N, 2012, CRIT CARE MED, V40, P2141, DOI 10.1097/CCM.0b013e31824e6713
   Henderson RJ, 2005, BBA-MOL CELL RES, V1743, P162, DOI 10.1016/j.bbamcr.2004.09.032
   Hentze MW, 2010, CELL, V142, P24, DOI 10.1016/j.cell.2010.06.028
   Holz MK, 2005, J BIOL CHEM, V280, P26089, DOI 10.1074/jbc.M504045200
   Hosokawa N, 2009, MOL BIOL CELL, V20, P1981, DOI 10.1091/mbc.E08-12-1248
   Inoki K, 2002, NAT CELL BIOL, V4, P648, DOI 10.1038/ncb839
   Inoki K, 2003, GENE DEV, V17, P1829, DOI 10.1101/gad.1110003
   Italia K, 2015, BLOOD CELL MOL DIS, V55, P194, DOI 10.1016/j.bcmd.2015.06.003
   Jahng JWS, 2015, ENDOCRINOLOGY, V156, P2667, DOI 10.1210/en.2015-1162
   Jung CH, 2009, MOL BIOL CELL, V20, P1992, DOI 10.1091/mbc.E08-12-1249
   Kao JK, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0156713
   Kim J, 2011, NAT CELL BIOL, V13, P132, DOI 10.1038/ncb2152
   Kimura S, 2007, AUTOPHAGY, V3, P452, DOI 10.4161/auto.4451
   Li Y, 2004, MOL CELL BIOL, V24, P7965, DOI 10.1128/MCB.24.18.7965-7975.2004
   Liu QS, 2010, J MED CHEM, V53, P7146, DOI 10.1021/jm101144f
   Liu QW, 2013, INDIAN J PHARMACOL, V45, P458, DOI 10.4103/0253-7613.117729
   Liu Y, 2015, DIABETES, V64, P36, DOI 10.2337/db14-0267
   MARTIN LE, 1955, BRIT J PHARM CHEMOTH, V10, P375, DOI 10.1111/j.1476-5381.1955.tb00887.x
   Matsunaga K, 2009, NAT CELL BIOL, V11, P385, DOI 10.1038/ncb1846
   McClain DA, 2006, DIABETOLOGIA, V49, P1661, DOI 10.1007/s00125-006-0200-0
   Mizushima N, 2011, CELL, V147, P728, DOI 10.1016/j.cell.2011.10.026
   Munson MJ, 2015, EMBO J, V34, P2272, DOI 10.15252/embj.201590992
   Palanivel R, 2006, DIABETOLOGIA, V49, P183, DOI 10.1007/s00125-005-0060-z
   Pantopoulos K, 2012, BIOCHEMISTRY-US, V51, P5705, DOI 10.1021/bi300752r
   Parmar N, 2010, ENZYMES, V27, P39, DOI 10.1016/S1874-6047(10)27003-8
   Rajpathak SN, 2009, BBA-GEN SUBJECTS, V1790, P671, DOI 10.1016/j.bbagen.2008.04.005
   Riemer J, 2004, ANAL BIOCHEM, V331, P370, DOI 10.1016/j.ab.2004.03.049
   Russell RC, 2014, CELL RES, V24, P42, DOI 10.1038/cr.2013.166
   Russell RC, 2013, NAT CELL BIOL, V15, P741, DOI 10.1038/ncb2757
   Sarparanta J, 2017, CURR DIABETES REV, V13, P352, DOI 10.2174/1573399812666160217122530
   Sebastiani G, 2011, METALLOMICS, V3, P971, DOI 10.1039/c1mt00082a
   Simcox JA, 2013, CELL METAB, V17, P329, DOI 10.1016/j.cmet.2013.02.007
   Thoreen CC, 2009, J BIOL CHEM, V284, P8023, DOI 10.1074/jbc.M900301200
   Varghese J, 2018, BBA-GEN SUBJECTS, V1862, P1870, DOI 10.1016/j.bbagen.2018.05.022
   Wang JA, 2011, BIOCHEM J, V434, P365, DOI 10.1042/BJ20101825
   Watson A, 2016, CELL SIGNAL, V28, P412, DOI 10.1016/j.cellsig.2016.01.014
   Wongjaikam S, 2015, EUR J PHARMACOL, V765, P86, DOI 10.1016/j.ejphar.2015.08.017
   Xu AM, 2015, AUTOPHAGY, V11, P723, DOI 10.1080/15548627.2015.1034418
   Xu G, 2012, J BIOL CHEM, V287, P4808, DOI 10.1074/jbc.M111.275719
   Yang JS, 2017, BIOMEDICINE-TAIWAN, V7, DOI 10.1051/bmdcn/2017070201
   Yu L, 2010, NATURE, V465, P942, DOI 10.1038/nature09076
   Zhang Y, 2014, CARDIOVASC RES, V102, P68, DOI 10.1093/cvr/cvu011
   Zheng QQ, 2018, CELL DEATH DIS, V9, DOI 10.1038/s41419-018-0552-7
   Zhuang TF, 2014, NUTRIENTS, V6, P3968, DOI 10.3390/nu6093968
   Zimmermann MB, 2007, LANCET, V370, P511, DOI 10.1016/S0140-6736(07)61235-5
NR 68
TC 66
Z9 76
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-221X
EI 1469-3178
J9 EMBO REP
JI EMBO Rep.
PD OCT 4
PY 2019
VL 20
IS 10
AR e47911
DI 10.15252/embr.201947911
EA AUG 2019
PG 18
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA JC0KS
UT WOS:000483203300001
PM 31441223
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Kitsiou-Tzeli, S
   Tzetis, M
AF Kitsiou-Tzeli, Sofia
   Tzetis, Maria
TI Maternal epigenetics and fetal and neonatal growth
SO CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
LA English
DT Review
DE imprinted genes; intrauterine growth restriction (IUGR); low infant
   birth weight; maternal epigenetics; metabolic syndrome
ID DNA METHYLATION; OBESITY; MECHANISMS; EXPRESSION; EVOLUTION; EXPOSURE;
   SMOKING; WEIGHT; IMPACT; GENES
AB Purpose of review
   The article provides an update on new insights of factors altering inherited maternal epigenome that ultimately affect fetal and neonatal growth.
   Recent findings
   A number of new publications have identified mechanisms through which maternal nutrition, environmental exposures such as stress and toxic substances altering expression of imprinted genes during pregnancy can influence fetal and neonatal phenotype and susceptibility to disease development later in life. The possible causes of metabolic syndrome by in-utero epigenetic alterations of genes involved in energy metabolism (PPAR gamma and PPAR alpha), microRNAs, arginine methyltransferases, lysine demethylases, and histone deacetylaces have been elucidated. Moreover associations between methylation of key genes (NRC31, HSD11 beta 1/2, GFI1) involved in the hypothalamic-pituitary-adrenal axis have been identified. Alcohol exposure during pregnancy was found to alter methylation patterns of several imprinted genes (H19, SLC22A18, SLC6A3, DRD4). Finally alterations in vulnerable epigenetic marks of imprinted genes such as H19/IGF2, during early stages of embryonic development result in intrauterine growth restriction.
   Summary
   All these investigations continue to provide new insights for improved clinical management of in-utero development.
C1 [Kitsiou-Tzeli, Sofia; Tzetis, Maria] Natl & Kapodistrian Univ Athens, Dept Med Genet, Sch Med, Athens, Greece.
C3 National & Kapodistrian University of Athens; Athens Medical School
RP Kitsiou-Tzeli, S (corresponding author), Natl & Kapodistrian Univ Athens, Dept Med Genet, Sch Med, Aghia Sophia Childrens Hosp, Athens 11527, Greece.
EM skitsiou@med.uoa.gr
RI Tzetis, Maria/K-5220-2012
OI Tzetis, Maria/0000-0002-6810-2922
CR Bauer T, 2016, MOL SYST BIOL, V12, DOI 10.15252/msb.20156520
   Biniszkiewicz D, 2002, MOL CELL BIOL, V22, P2124, DOI 10.1128/MCB.22.7.2124-2135.2002
   Carreras-Badosa G, 2015, J CLIN ENDOCR METAB, V100, pE1446, DOI 10.1210/jc.2015-2872
   Cowan CSM, 2016, GENES BRAIN BEHAV, V15, P155, DOI 10.1111/gbb.12263
   Desai M, 2015, INT J OBESITY, V39, P633, DOI 10.1038/ijo.2015.13
   El Hajj N, 2013, DIABETES, V62, P1320, DOI 10.2337/db12-0289
   Elshenawy S, 2016, MOL CELL ENDOCRINOL, V435, P2, DOI 10.1016/j.mce.2016.07.002
   Funato H, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0018950
   Gonzalez-Rodriguez P, 2016, AM J OBSTET GYNECOL, V214, DOI 10.1016/j.ajog.2016.01.194
   Hermann A, 2004, J BIOL CHEM, V279, P48350, DOI 10.1074/jbc.M403427200
   Kaneda M, 2004, NATURE, V429, P900, DOI 10.1038/nature02633
   Keniry A, 2012, NAT CELL BIOL, V14, P659, DOI 10.1038/ncb2521
   Knight AK, 2016, GENES-BASEL, V7, DOI 10.3390/genes7040015
   Kupers LK, 2015, INT J EPIDEMIOL, V44, P1224, DOI 10.1093/ije/dyv048
   Laufer BI, 2015, EPIGENOMICS-UK, V7, P1259, DOI 10.2217/epi.15.60
   Lee HS, 2015, NUTRIENTS, V7, P9492, DOI 10.3390/nu7115467
   McGowan Patrick O, 2013, Front Psychiatry, V4, P110, DOI 10.3389/fpsyt.2013.00110
   Nagarajan S, 2016, EPIGENOMICS-UK, V8, P925, DOI 10.2217/epi.16.9
   Panchenko PE, 2016, CLIN EPIGENETICS, V8, DOI 10.1186/s13148-016-0188-3
   Portales-Casamar E, 2016, EPIGENET CHROMATIN, V9, DOI 10.1186/s13072-016-0074-4
   Reik W, 2001, NAT REV GENET, V2, P21, DOI 10.1038/35047554
   Reik W, 2001, NAT GENET, V27, P255, DOI 10.1038/85804
   Sasson IE, 2015, DIABETOLOGIA, V58, P615, DOI 10.1007/s00125-014-3466-7
   Szyf M, 2015, TRENDS MOL MED, V21, P134, DOI 10.1016/j.molmed.2014.12.004
   Tomlinson JW, 2004, ENDOCR REV, V25, P831, DOI 10.1210/er.2003-0031
   Van den Veyver IB, 2002, ANNU REV NUTR, V22, P255, DOI 10.1146/annurev.nutr.22.010402.102932
   Willbanks A, 2016, GENET EPIGENETICS, V8, P25, DOI 10.4137/GEG.S31863
   Yokochi T, 2002, J BIOL CHEM, V277, P11735, DOI 10.1074/jbc.M106590200
   Zhang GQ, 2014, IUBMB LIFE, V66, P240, DOI 10.1002/iub.1264
NR 29
TC 63
Z9 65
U1 0
U2 58
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1752-296X
EI 1752-2978
J9 CURR OPIN ENDOCRINOL
JI Curr. Opin. Endocrinol. Diabetes Obes.
PD FEB
PY 2017
VL 24
IS 1
BP 43
EP 46
DI 10.1097/MED.0000000000000305
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EI0NS
UT WOS:000392171800010
PM 27898587
DA 2025-06-11
ER

PT J
AU Medina, J
   Fernández-Salazar, LI
   García-Buey, L
   Moreno-Otero, R
AF Medina, J
   Fernández-Salazar, LI
   García-Buey, L
   Moreno-Otero, R
TI Approach to the pathogenesis and treatment of nonalcoholic
   steatohepatitis
SO DIABETES CARE
LA English
DT Review
ID TUMOR-NECROSIS-FACTOR; FATTY LIVER-DISEASE; HEPATIC CYTOCHROME-P450 2E1;
   INDUCED INSULIN-RESISTANCE; FACTOR-ALPHA; BODY-WEIGHT; MITOCHONDRIAL
   DYSFUNCTION; URSODEOXYCHOLIC ACID; METABOLIC SYNDROME; IRON OVERLOAD
AB Nonalcoholic steatohepatitis (NASH) represents art advanced stage of fatty liver disease developed in the absence of alcohol abuse. Its increasing prevalence in western countries, the diagnostic difficulties by noninvasive tests, and the possibility of progression to advanced fibrosis and even cirrhosis make NASH a challenge for hepatologists. NASH is frequently associated with type 2 diabetes and the metabolic syndrome, and several genetic and acquired factors are involved in its pathogenesis. Insulin resistance plays a central role in the development of a steatotic liver which becomes vulnerable to additional injuries. Several cyclic mechanisms leading to self-enhancement of insulin resistance and hepatic accumulation of fat have been recently identified. Excess intracellular fatty acids, oxidant stress, tumor necrosis factor-alpha, and mitochondrial dysfunction arc causes of hepatocellular injury, thereby leading to disease progression and to the establishment of NASH. Intestinal bacterial overgrowth also plays a role, by increasing production of endogenous ethanol and proinflammatory Cytokines. Therapeutic strategies aimed It modulating insulin resistance, normalizing lipoprotein metabolism, and downregulating inflammatory mediators with probiotics have promising potential.
C1 Autonomous Univ Madrid, Univ Hosp La Princesa, Liver Unit, E-28049 Madrid, Spain.
   Univ Hosp, Digest Dis Serv, Valladolid, Spain.
C3 Autonomous University of Madrid
RP Hosp Univ Princesa, Unidad Hepatol, Planta 3,Diego Leon 62, E-28006 Madrid, Spain.
EM rmoreno.hlpr@salud.madrid.org
RI Medina, Jesus/J-4785-2015; Fernández Salazar, Luis/GLN-5812-2022
OI Fernandez-Salazar, Luis/0000-0002-9951-7979
CR Abdelmalek MF, 2001, AM J GASTROENTEROL, V96, P2711
   ADACHI Y, 1995, GASTROENTEROLOGY, V108, P218, DOI 10.1016/0016-5085(95)90027-6
   Alba LM, 2003, ALIMENT PHARM THER, V17, P977, DOI 10.1046/j.1365-2036.2003.01493.x
   Angulo P, 1999, HEPATOLOGY, V30, P1356, DOI 10.1002/hep.510300604
   Arner P, 1998, LANCET, V351, P1301, DOI 10.1016/S0140-6736(05)79052-8
   Baffy G, 2002, HEPATOLOGY, V35, P753, DOI 10.1053/jhep.2002.32028
   Barsh GS, 2000, NATURE, V404, P644, DOI 10.1038/35007519
   Basaranoglu M, 1999, J HEPATOL, V31, P384, DOI 10.1016/S0168-8278(99)80243-8
   Bernard S, 2000, DIABETOLOGIA, V43, P995, DOI 10.1007/s001250051481
   Berson A, 1998, GASTROENTEROLOGY, V114, P764, DOI 10.1016/S0016-5085(98)70590-6
   Bonkovsky HL, 1999, J HEPATOL, V31, P421, DOI 10.1016/S0168-8278(99)80032-4
   Brunt EM, 1999, AM J GASTROENTEROL, V94, P2467, DOI 10.1111/j.1572-0241.1999.01377.x
   Bugianesi E, 2004, HEPATOLOGY, V39, P179, DOI 10.1002/hep.20023
   BUGRANESI E, 2003, J HEPATOL A, V38, pA3620
   Caballería J, 1998, J HEPATOL, V28, P54, DOI 10.1016/S0168-8278(98)80202-X
   Caldwell SH, 2001, AM J GASTROENTEROL, V96, P519
   Cassader M, 2001, LIPIDS, V36, P1117, DOI 10.1007/s11745-001-0822-5
   Chalasani N, 2003, HEPATOLOGY, V37, P544, DOI 10.1053/jhep.2003.50095
   Chalasani N, 2003, AM J GASTROENTEROL, V98, P2771, DOI [10.1016/j.amjgastroenterol.2003.09.037, 10.1111/j.1572-0241.2003.08767.x]
   Charlton N, 2002, HEPATOLOGY, V35, P898, DOI 10.1053/jhep.2002.32527
   Chavin KD, 1999, J BIOL CHEM, V274, P5692, DOI 10.1074/jbc.274.9.5692
   Chitturi S, 2002, HEPATOLOGY, V35, P373, DOI 10.1053/jhep.2002.30692
   Chitturi S, 2002, HEPATOLOGY, V36, P142, DOI 10.1053/jhep.2002.33892
   Chitturi S, 2002, HEPATOLOGY, V36, P403, DOI 10.1053/jhep.2002.34738
   Chitturi S, 2001, SEMIN LIVER DIS, V21, P27, DOI 10.1055/s-2001-12927
   Chitturi Shivakumar, 2003, Curr Gastroenterol Rep, V5, P18, DOI 10.1007/s11894-003-0005-y
   Clark JM, 2002, GASTROENTEROLOGY, V122, P1649, DOI 10.1053/gast.2002.33573
   Clark JM, 2003, AM J GASTROENTEROL, V98, P960, DOI [10.1016/S0002-9270(03)00265-X, 10.1111/j.1572-0241.2003.07486.x]
   Clarke SD, 2001, AM J PHYSIOL-GASTR L, V281, pG865, DOI 10.1152/ajpgi.2001.281.4.G865
   Cohen B, 1996, SCIENCE, V274, P1185, DOI 10.1126/science.274.5290.1185
   Cope K, 2000, GASTROENTEROLOGY, V119, P1340, DOI 10.1053/gast.2000.19267
   Cortez-Pinto H, 1999, JAMA-J AM MED ASSOC, V282, P1659, DOI 10.1001/jama.282.17.1659
   Crespo J, 2001, HEPATOLOGY, V34, P1158, DOI 10.1053/jhep.2001.29628
   D'Souza-Gburek S M, 1997, Liver Transpl Surg, V3, P23
   Day CP, 2002, GUT, V50, P585, DOI 10.1136/gut.50.5.585
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   Dixon JB, 2001, GASTROENTEROLOGY, V121, P91, DOI 10.1053/gast.2001.25540
   DRENICK EJ, 1982, GASTROENTEROLOGY, V82, P535
   DRENICK EJ, 1970, NEW ENGL J MED, V282, P829, DOI 10.1056/NEJM197004092821502
   Echtay KS, 2002, NATURE, V415, P96, DOI 10.1038/415096a
   Falck-Ytter Y, 2001, SEMIN LIVER DIS, V21, P17, DOI 10.1055/s-2001-12926
   Fargion S, 2001, AM J GASTROENTEROL, V96, P2448, DOI 10.1111/j.1572-0241.2001.04052.x
   Flora K, 1998, AM J GASTROENTEROL, V93, P139, DOI 10.1111/j.1572-0241.1998.00139.x
   Friedman JM, 1998, NATURE, V395, P763, DOI 10.1038/27376
   Galli A, 2001, J BIOL CHEM, V276, P68, DOI 10.1074/jbc.M008791200
   García-Monzón C, 2000, J HEPATOL, V33, P716, DOI 10.1016/S0168-8278(00)80301-3
   George DK, 1998, GASTROENTEROLOGY, V114, P311, DOI 10.1016/S0016-5085(98)70482-2
   Grove J, 1997, HEPATOLOGY, V26, P143, DOI 10.1002/hep.510260119
   Grove J, 2000, GUT, V46, P540, DOI 10.1136/gut.46.4.540
   Harrison SA, 2003, AM J GASTROENTEROL, V98, P926, DOI 10.1111/j.1572-0241.2003.07375.x
   Hasegawa T, 2001, ALIMENT PHARM THERAP, V15, P1667, DOI 10.1046/j.1365-2036.2001.01083.x
   Honda H, 2002, HEPATOLOGY, V36, P12, DOI 10.1053/jhep.2002.33684
   HRUSZKEWYCZ AM, 1988, BIOCHEM BIOPH RES CO, V153, P191, DOI 10.1016/S0006-291X(88)81207-5
   JENSEN MD, 1989, J CLIN INVEST, V83, P1168, DOI 10.1172/JCI113997
   Kaplan LM, 1998, GASTROENTEROLOGY, V115, P997, DOI 10.1016/S0016-5085(98)70272-0
   KERN PA, 1995, J CLIN INVEST, V95, P2111, DOI 10.1172/JCI117899
   Kirpichnikov D, 2002, ANN INTERN MED, V137, P25, DOI 10.7326/0003-4819-137-1-200207020-00009
   Koteish A, 2001, SEMIN LIVER DIS, V21, P89, DOI 10.1055/s-2001-12932
   Kugelmas M, 2003, HEPATOLOGY, V38, P413, DOI 10.1053/jhep.2003.50316
   Laurin J, 1996, HEPATOLOGY, V23, P1464
   Leclercq IA, 2000, J CLIN INVEST, V105, P1067, DOI 10.1172/JCI8814
   Lee Y, 2001, J BIOL CHEM, V276, P5629, DOI 10.1074/jbc.M008553200
   Li ZP, 2003, HEPATOLOGY, V37, P343, DOI 10.1053/jhep.2003.50048
   Li ZP, 2002, GASTROENTEROLOGY, V123, P1304, DOI 10.1053/gast.2002.35997
   Lin HZ, 2000, NAT MED, V6, P998, DOI 10.1038/79697
   Lindor KD, 2004, HEPATOLOGY, V39, P770, DOI 10.1002/hep.20092
   Loffreda S, 1998, FASEB J, V12, P57, DOI 10.1096/fasebj.12.1.57
   Loguercio C, 2002, AM J GASTROENTEROL, V97, P2144
   Ludwig J, 1997, GASTROENTEROLOGY, V112, P882, DOI 10.1053/gast.1997.v112.pm9041250
   Ludwig J, 1997, J GASTROEN HEPATOL, V12, P398, DOI 10.1111/j.1440-1746.1997.tb00450.x
   MADDUX BA, 1995, NATURE, V373, P448, DOI 10.1038/373448a0
   Marchesini G, 2003, HEPATOLOGY, V37, P917, DOI 10.1053/jhep.2003.50161
   Marchesini G, 2001, DIABETES, V50, P1844, DOI 10.2337/diabetes.50.8.1844
   Marchesini G, 2001, LANCET, V358, P893, DOI 10.1016/S0140-6736(01)06042-1
   Masuzaki H, 2001, SCIENCE, V294, P2166, DOI 10.1126/science.1066285
   Matteoni CA, 1999, GASTROENTEROLOGY, V116, P1413, DOI 10.1016/S0016-5085(99)70506-8
   Mendler MH, 1999, GASTROENTEROLOGY, V117, P1155, DOI 10.1016/S0016-5085(99)70401-4
   Mezey E, 1998, HEPATOLOGY, V28, P901, DOI 10.1002/hep.510280401
   Moirand R, 1997, LANCET, V349, P95, DOI 10.1016/S0140-6736(96)06034-5
   Musso G, 2003, HEPATOLOGY, V37, P909, DOI 10.1053/jhep.2003.50132
   Nair S, 2001, AM J GASTROENTEROL, V96, P1200, DOI 10.1111/j.1572-0241.2001.03702.x
   Neuschwander-Tetri BA, 2003, HEPATOLOGY, V38, P1008, DOI 10.1053/jhep.2003.50420
   Neuschwander-Tetri BA, 2003, HEPATOLOGY, V37, P1202, DOI 10.1053/jhep.2003.50193
   Neuschwander-Tetri BA, 2003, J HEPATOL, V38, P434, DOI 10.1016/S0168-8278(03)00027-8
   NeuschwanderTetri BA, 1996, MED CLIN N AM, V80, P1147, DOI 10.1016/S0025-7125(05)70483-1
   OSMAN E, 1993, ALIMENT PHARM THER, V7, P21
   Pagano G, 2002, HEPATOLOGY, V35, P367, DOI 10.1053/jhep.2002.30690
   PALMER M, 1990, GASTROENTEROLOGY, V99, P1408, DOI 10.1016/0016-5085(90)91169-7
   Paradis V, 2001, HEPATOLOGY, V34, P738, DOI 10.1053/jhep.2001.28055
   Pessayre D, 2002, AM J PHYSIOL-GASTR L, V282, pG193, DOI 10.1152/ajpgi.00426.2001
   Pessayre D, 2001, SEMIN LIVER DIS, V21, P57, DOI 10.1055/s-2001-12929
   Poullis A, 2001, GUT, V49, P313, DOI 10.1136/gut.49.2.313
   POWELL EE, 1989, GASTROENTEROLOGY, V97, P1022, DOI 10.1016/0016-5085(89)91513-8
   Promrat K, 2004, HEPATOLOGY, V39, P188, DOI 10.1002/hep.20012
   Rashid A, 1999, HEPATOLOGY, V29, P1131, DOI 10.1002/hep.510290428
   Ratziu V, 2000, GASTROENTEROLOGY, V118, P1117, DOI 10.1016/S0016-5085(00)70364-7
   Reddy JK, 2001, AM J PHYSIOL-GASTR L, V281, pG1333, DOI 10.1152/ajpgi.2001.281.6.G1333
   REYNET C, 1993, SCIENCE, V262, P1441, DOI 10.1126/science.8248782
   Robertson Graham, 2001, American Journal of Physiology, V281, pG1135
   Saibara T, 1999, LANCET, V353, P1802, DOI 10.1016/S0140-6736(05)75907-9
   Sanyal AJ, 2001, GASTROENTEROLOGY, V120, P1183, DOI 10.1053/gast.2001.23256
   Satapathy SK, 2003, GASTROENTEROLOGY, V124, pA758, DOI 10.1016/S0016-5085(03)83831-3
   Savage DB, 2003, DIABETES, V52, P910, DOI 10.2337/diabetes.52.4.910
   Saxena NK, 2002, HEPATOLOGY, V35, P762, DOI 10.1053/jhep.2002.32029
   Shepherd PR, 1999, NEW ENGL J MED, V341, P248, DOI 10.1056/NEJM199907223410406
   Sheth SG, 1997, ANN INTERN MED, V126, P137, DOI 10.7326/0003-4819-126-2-199701150-00008
   Solga SF, 2003, J HEPATOL, V38, P681, DOI 10.1016/S0168-8278(03)00097-7
   Tilg H, 2000, NEW ENGL J MED, V343, P1467, DOI 10.1056/NEJM200011163432007
   Ueno T, 1997, J HEPATOL, V27, P103, DOI 10.1016/S0168-8278(97)80287-5
   Unger RH, 2002, BBA-MOL CELL BIOL L, V1585, P202, DOI 10.1016/S1388-1981(02)00342-6
   Uygun A, 2004, ALIMENT PHARM THER, V19, P537, DOI 10.1111/j.1365-2036.2004.01888.x
   Uygun A, 2000, AM J GASTROENTEROL, V95, P3584
   Uysal KT, 1997, NATURE, V389, P610, DOI 10.1038/39335
   Valenti L, 2002, GASTROENTEROLOGY, V122, P274, DOI 10.1053/gast.2002.31065
   WANLESS IR, 1990, HEPATOLOGY, V12, P1106, DOI 10.1002/hep.1840120505
   Weltman MD, 1998, HEPATOLOGY, V27, P128, DOI 10.1002/hep.510270121
   Wigg AJ, 2001, GUT, V48, P206, DOI 10.1136/gut.48.2.206
   Willner IR, 2001, AM J GASTROENTEROL, V96, P2957
   Yang SQ, 1997, P NATL ACAD SCI USA, V94, P2557, DOI 10.1073/pnas.94.6.2557
   Yin M, 1999, GASTROENTEROLOGY, V117, P942, DOI 10.1016/S0016-5085(99)70354-9
   Younossi ZM, 1999, HEPATOLOGY, V30, P847, DOI 10.1002/hep.510300407
   Yuan MS, 2001, SCIENCE, V293, P1673, DOI 10.1126/science.1061620
   Zeviani M, 1998, MEDICINE, V77, P59, DOI 10.1097/00005792-199801000-00006
NR 123
TC 161
Z9 192
U1 1
U2 5
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD AUG
PY 2004
VL 27
IS 8
BP 2057
EP 2066
DI 10.2337/diacare.27.8.2057
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 842TD
UT WOS:000223026200035
PM 15277442
OA Bronze
DA 2025-06-11
ER

PT J
AU Pitsillou, E
   Liang, JL
   Hung, A
   Karagiannis, TC
AF Pitsillou, Eleni
   Liang, Julia
   Hung, Andrew
   Karagiannis, Tom C.
TI The circadian machinery links metabolic disorders and depression: A
   review of pathways, proteins and potential pharmacological interventions
SO LIFE SCIENCES
LA English
DT Review
DE Circadian rhythm; Central circadian clock; Clock proteins; Epigenetic
   modifications; Metabolic disorders; Major depressive disorder
ID SMALL-MOLECULE INHIBITOR; ELEMENT-BINDING PROTEIN; D-ASPARTATE
   RECEPTORS; SLEEP-PHASE SYNDROME; X-RAY-STRUCTURE; HIGH-FAT DIET; HISTONE
   DEMETHYLASE; INSULIN-RESISTANCE; BLUE-LIGHT; SUPRACHIASMATIC NUCLEUS
AB Circadian rhythms are responsible for regulating a number of physiological processes. The central oscillator is located within the suprachiasmatic nucleus (SCN) of the hypothalamus and the SCN synchronises the circadian clocks that are found in our peripheral organs through neural and humoral signalling. At the molecular level, biological clocks consist of transcription-translation feedback loops (TTFLs) and these pathways are influenced by transcription factors, post-translational modifications, signalling pathways and epigenetic modifiers. When disruptions occur in the circadian machinery, the activities of the proteins implicated in this network and the expression of core clock or clock-controlled genes (CCGs) can be altered. Circadian misalignment can also arise when there is desychronisation between our internal clocks and environmental stimuli.
   There is evidence in the literature demonstrating that disturbances in the circadian rhythm contribute to the pathophysiology of several diseases and disorders. This includes the metabolic syndrome and recently, it has been suggested that the 'circadian syndrome' may be a more appropriate term to use to not only describe the cardio-metabolic risk factors but also the associated comorbidities. Here we overview the molecular architecture of circadian clocks in mammals and provide insight into the effects of shift work, exposure to artificial light, food intake and stress on the circadian rhythm. The relationship between circadian rhythms, metabolic disorders and depression is reviewed and this is a topic that requires further investigation. We also describe how particular proteins involved in the TTFLs can be potentially modulated by small molecules, including pharmacological interventions and dietary compounds.
C1 [Pitsillou, Eleni; Liang, Julia; Karagiannis, Tom C.] Monash Univ, Cent Clin Sch, Dept Diabet, Epigen Med, Melbourne, Vic 3004, Australia.
   [Pitsillou, Eleni; Liang, Julia; Hung, Andrew] RMIT Univ, Coll Sci Engn & Hlth, Sch Sci, Melbourne, Vic 3001, Australia.
   [Karagiannis, Tom C.] Univ Melbourne, Dept Clin Pathol, Parkville, Vic 3052, Australia.
C3 Monash University; Royal Melbourne Institute of Technology (RMIT);
   University of Melbourne
RP Karagiannis, TC (corresponding author), Monash Univ, Cent Clin Sch, Dept Diabet, Epigen Med Program, Melbourne, Vic 3004, Australia.
EM tom.karagiannis@monash.edu
RI ; Liang, Julia J/LKM-6635-2024
OI Hung, Andrew/0000-0003-3569-2951; Liang, Julia J/0000-0002-3031-3169;
   Karagiannis, Tom/0000-0002-9967-1546
FU McCord Research (Iowa, USA); Australian Government Research Training
   Program Scholarship
FX We would like to acknowledge intellectual and financial support by
   McCord Research (Iowa, USA). JL is supported by an Australian Government
   Research Training Program Scholarship. Several of the figures were
   created with BioRender.com.
CR Abbas M, 2014, J MANAGE, V40, P1813, DOI 10.1177/0149206312455243
   Abdulla Arian, 2013, J Biochem Pharmacol Res, V1, P56
   Aguilar-Arnal L, 2015, P NATL ACAD SCI USA, V112, P6863, DOI 10.1073/pnas.1411264111
   Aguilar-Arnal L, 2015, NAT STRUCT MOL BIOL, V22, P312, DOI 10.1038/nsmb.2990
   Akashi M, 2005, NAT STRUCT MOL BIOL, V12, P441, DOI 10.1038/nsmb925
   Akashi M, 2000, GENE DEV, V14, P645
   Akashi M, 2002, MOL CELL BIOL, V22, P1693, DOI 10.1128/MCB.22.6.1693-1703.2002
   Almoosawi S, 2019, ADV NUTR, V10, P30, DOI 10.1093/advances/nmy070
   Amador A, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0151014
   Aquilano K, 2019, COMMUN BIOL, V2, DOI 10.1038/s42003-019-0563-7
   Arai AC, 2000, MOL PHARMACOL, V58, P802, DOI 10.1124/mol.58.4.802
   Asher G, 2008, CELL, V134, P317, DOI 10.1016/j.cell.2008.06.050
   Ayaki M, 2016, CHRONOBIOL INT, V33, P134, DOI 10.3109/07420528.2015.1119158
   Bakhtiari Afsaneh, 2018, Iran J Psychiatry, V13, P230
   Balasubramanyam K, 2004, J BIOL CHEM, V279, P51163, DOI 10.1074/jbc.M409024200
   Balasubramanyam K, 2004, J BIOL CHEM, V279, P33716, DOI 10.1074/jbc.M402839200
   Balasubramanyam K, 2003, J BIOL CHEM, V278, P19134, DOI 10.1074/jbc.M301580200
   Barandas R, 2015, CURR PSYCHIAT REP, V17, DOI 10.1007/s11920-015-0637-2
   Barion A, 2007, SLEEP MED, V8, P566, DOI 10.1016/j.sleep.2006.11.017
   Bellet MM, 2013, P NATL ACAD SCI USA, V110, P3333, DOI 10.1073/pnas.1214266110
   Bellet MM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023982
   Bernstein BE, 2006, CELL, V125, P315, DOI 10.1016/j.cell.2006.02.041
   Besedovsky L, 2019, PHYSIOL REV, V99, P1325, DOI 10.1152/physrev.00010.2018
   Bilu C, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-48326-7
   Bowers EM, 2010, CHEM BIOL, V17, P471, DOI 10.1016/j.chembiol.2010.03.006
   Breen ME, 2018, CURR OPIN CHEM BIOL, V45, P195, DOI 10.1016/j.cbpa.2018.06.005
   Bruggemann E, 1996, PLANT J, V10, P755, DOI 10.1046/j.1365-313X.1996.10040755.x
   Bunney BG, 2015, MOL PSYCHIATR, V20, P48, DOI 10.1038/mp.2014.138
   Burke TM, 2015, SCI TRANSL MED, V7, DOI 10.1126/scitranslmed.aac5125
   Busino L, 2007, SCIENCE, V316, P900, DOI 10.1126/science.1141194
   Camacho F, 2001, FEBS LETT, V489, P159, DOI 10.1016/S0014-5793(00)02434-0
   Cardinali DP, 2012, J PINEAL RES, V52, P365, DOI 10.1111/j.1600-079X.2011.00962.x
   Carter DA, 1996, MOL CELL ENDOCRINOL, V124, P1, DOI 10.1016/S0303-7207(96)03962-7
   Cawthorn WP, 2008, FEBS LETT, V582, P117, DOI 10.1016/j.febslet.2007.11.051
   Cenciarelli C, 1999, CURR BIOL, V9, P1177, DOI 10.1016/S0960-9822(00)80020-2
   Chan KL, 2019, PHYSIOLOGY, V34, P123, DOI 10.1152/physiol.00047.2018
   Chang AM, 2015, P NATL ACAD SCI USA, V112, P1232, DOI 10.1073/pnas.1418490112
   Chang HC, 2014, TRENDS ENDOCRIN MET, V25, P138, DOI 10.1016/j.tem.2013.12.001
   Chen DH, 2019, EBIOMEDICINE, V50, P395, DOI 10.1016/j.ebiom.2019.10.054
   Chen SK, 2011, NATURE, V476, P92, DOI 10.1038/nature10206
   CHENARD BL, 1995, J MED CHEM, V38, P3138, DOI 10.1021/jm00016a017
   CHIZH BA, 1994, BRIT J PHARMACOL, V112, P843, DOI 10.1111/j.1476-5381.1994.tb13156.x
   Chizh BA, 2001, TRENDS PHARMACOL SCI, V22, P636, DOI 10.1016/S0165-6147(00)01863-0
   Choi KC, 2009, MOL CANCER RES, V7, P2011, DOI 10.1158/1541-7786.MCR-09-0239
   Chong JX, 2016, GENET MED, V18, P788, DOI 10.1038/gim.2015.161
   Coll AP, 2013, CURR OPIN PHARMACOL, V13, P970, DOI 10.1016/j.coph.2013.09.010
   Cuyàs E, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071656
   Daly EJ, 2019, JAMA PSYCHIAT, V76, P893, DOI 10.1001/jamapsychiatry.2019.1189
   Damiola F, 2000, GENE DEV, V14, P2950, DOI 10.1101/gad.183500
   Dandona P, 2004, TRENDS IMMUNOL, V25, P4, DOI 10.1016/j.it.2003.10.013
   De Mei C, 2015, ONCOGENE, V34, P2597, DOI 10.1038/onc.2014.203
   DeBruyne JP, 2007, NAT NEUROSCI, V10, P543, DOI 10.1038/nn1884
   Deshaies RJ, 1999, ANNU REV CELL DEV BI, V15, P435, DOI 10.1146/annurev.cellbio.15.1.435
   DING JM, 1994, SCIENCE, V266, P1713, DOI 10.1126/science.7527589
   DiTacchio L, 2011, SCIENCE, V333, P1881, DOI 10.1126/science.1206022
   DMITRZAKWEGLARZ M, 2017, NEUROPSYCHOBIOLOGY, P117
   Doi M, 2006, CELL, V125, P497, DOI 10.1016/j.cell.2006.03.033
   Dong K, 2019, INT J COSMETIC SCI, V41, P558, DOI 10.1111/ics.12572
   Doolin K, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18102226
   Duman Ronald S, 2018, F1000Res, V7, DOI 10.12688/f1000research.14344.1
   Dunbar JA, 2008, DIABETES CARE, V31, P2368, DOI 10.2337/dc08-0175
   Eide EJ, 2005, MOL CELL BIOL, V25, P2795, DOI 10.1128/MCB.25.7.2795-2807.2005
   Emami KH, 2004, P NATL ACAD SCI USA, V101, P12682, DOI 10.1073/pnas.0404875101
   Etchegaray JP, 2006, J BIOL CHEM, V281, P21209, DOI 10.1074/jbc.M603722200
   Etchegaray JP, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010303
   FAGG GE, 1990, BRIT J PHARMACOL, V99, P791, DOI 10.1111/j.1476-5381.1990.tb13008.x
   Fang Y, 2019, J HEMATOL ONCOL, V12, DOI 10.1186/s13045-019-0811-9
   Fischer G, 1997, J PHARMACOL EXP THER, V283, P1285
   Flanagan A, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041053
   Forneris F, 2007, J BIOL CHEM, V282, P20070, DOI 10.1074/jbc.C700100200
   FRANCK UF, 1980, BER BUNSEN PHYS CHEM, V84, P334, DOI 10.1002/bbpc.19800840407
   Freland L, 2012, FRONT MOL NEUROSCI, V5, DOI 10.3389/fnmol.2012.00014
   GANNON RL, 1994, MOL BRAIN RES, V23, P338, DOI 10.1016/0169-328X(94)90244-5
   Geer EB, 2014, ENDOCRIN METAB CLIN, V43, P75, DOI 10.1016/j.ecl.2013.10.005
   Gekakis N, 1998, SCIENCE, V280, P1564, DOI 10.1126/science.280.5369.1564
   Gheshlagh RG, 2016, IRAN RED CRESCENT ME, V18, DOI 10.5812/ircmj.26523
   GINTY DD, 1993, SCIENCE, V260, P238, DOI 10.1126/science.8097062
   Gloston GF, 2017, FRONT NEUROL, V8, DOI 10.3389/fneur.2017.00100
   Grant D, 2010, ACS CHEM BIOL, V5, P925, DOI 10.1021/cb100141y
   Griffin EA, 1999, SCIENCE, V286, P768, DOI 10.1126/science.286.5440.768
   Guillaumond F, 2005, J BIOL RHYTHM, V20, P391, DOI 10.1177/0748730405277232
   Guo GL, 2019, J BIOL RHYTHM, V34, P482, DOI 10.1177/0748730419865406
   Guo R, 2018, J AGR FOOD CHEM, V66, P9667, DOI 10.1021/acs.jafc.8b02147
   Guo TT, 2019, J AGR FOOD CHEM, V67, P11969, DOI 10.1021/acs.jafc.9b04869
   Hammitzsch A, 2015, P NATL ACAD SCI USA, V112, P10768, DOI 10.1073/pnas.1501956112
   Hardeland R, 2018, J PINEAL RES, V65, DOI 10.1111/jpi.12525
   Harrington ME, 1999, J NEUROSCI, V19, P6637
   He BK, 2016, CELL METAB, V23, P610, DOI 10.1016/j.cmet.2016.03.007
   Helleboid S, 2014, J BIOMOL SCREEN, V19, P399, DOI 10.1177/1087057113497095
   Hering Yuliya, 2018, Journal of Biological Methods, V5, pe94, DOI 10.14440/jbm.2018.244
   Herman JP, 2016, COMPR PHYSIOL, V6, P603, DOI 10.1002/cphy.c150015
   Heyde I, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-56323-z
   Hirano A, 2013, CELL, V152, P1106, DOI 10.1016/j.cell.2013.01.054
   Hirayama J, 2007, NATURE, V450, P1086, DOI 10.1038/nature06394
   Hirota T, 2012, SCIENCE, V337, P1094, DOI 10.1126/science.1223710
   Hittle BM, 2020, WESTERN J NURS RES, V42, P1031, DOI 10.1177/0193945920916802
   Hosoda H, 2009, MOL BRAIN, V2, DOI 10.1186/1756-6606-2-34
   Hsu DS, 1996, BIOCHEMISTRY-US, V35, P13871, DOI 10.1021/bi962209o
   Huh JR, 2013, ACS MED CHEM LETT, V4, P79, DOI 10.1021/ml300286h
   Huh JR, 2011, NATURE, V472, P486, DOI 10.1038/nature09978
   Huh Y, 2020, CPT-PHARMACOMET SYST, V9, P60, DOI 10.1002/psp4.12483
   Hunter CM, 2017, BIOL RES NURS, V19, P365, DOI 10.1177/1099800417714069
   Husse J, 2014, FASEB J, V28, P4950, DOI 10.1096/fj.14-256594
   Imhof A., 2018, EPIGENETICS METABOLI, P9
   Irwin MR, 2016, BIOL PSYCHIAT, V80, P40, DOI 10.1016/j.biopsych.2015.05.014
   Jang J, 2018, LIFE SCI, V200, P49, DOI 10.1016/j.lfs.2018.03.022
   JARRETT RJ, 1969, BRIT MED J, V2, P341, DOI 10.1136/bmj.2.5653.341
   Jin LH, 2010, MOL ENDOCRINOL, V24, P923, DOI 10.1210/me.2009-0507
   Jones CR, 1999, NAT MED, V5, P1062, DOI 10.1038/12502
   Kallen J, 2004, J BIOL CHEM, V279, P14033, DOI 10.1074/jbc.M400302200
   Kallen JA, 2002, STRUCTURE, V10, P1697, DOI 10.1016/S0969-2126(02)00912-7
   Kalsbeek A., 2015, NEUROENDOCRINOLOGY S, P219, DOI [10.1002/9781118921692.ch10, DOI 10.1002/9781118921692.CH10]
   Kashiwagi K, 2002, MOL PHARMACOL, V61, P533, DOI 10.1124/mol.61.3.533
   Katada S, 2010, NAT STRUCT MOL BIOL, V17, P1414, DOI 10.1038/nsmb.1961
   Kavakli I.H., 2020, CLOCK BINDING SMALL
   Keesler GA, 2000, NEUROREPORT, V11, P951, DOI 10.1097/00001756-200004070-00011
   Keller J, 2017, MOL PSYCHIATR, V22, P527, DOI 10.1038/mp.2016.120
   Kim K, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00215-1
   Kim SM, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-45322-9
   King DP, 1997, CELL, V89, P641, DOI 10.1016/S0092-8674(00)80245-7
   King DP, 1997, GENETICS, V146, P1049
   Köhler O, 2016, CURR NEUROPHARMACOL, V14, P732, DOI 10.2174/1570159X14666151208113700
   Kojetin D, 2011, ACS CHEM BIOL, V6, P131, DOI 10.1021/cb1002575
   Kopf D, 2004, J CLIN PSYCHOPHARM, V24, P527, DOI 10.1097/01.jcp.0000138762.23482.63
   Korczak DJ, 2011, DIABETOLOGIA, V54, P2483, DOI 10.1007/s00125-011-2240-3
   Korgaonkar MS, 2013, NEUROPSYCHOPHARMACOL, V38, P863, DOI 10.1038/npp.2012.252
   Kuang Z, 2019, SCIENCE, V365, P1428, DOI 10.1126/science.aaw3134
   Kumar N, 2012, ACS CHEM BIOL, V7, P672, DOI 10.1021/cb200496y
   Kumar N, 2011, ACS CHEM BIOL, V6, P218, DOI 10.1021/cb1002762
   Kumar N, 2010, MOL PHARMACOL, V77, P228, DOI 10.1124/mol.109.060905
   Kume K, 1999, CELL, V98, P193, DOI 10.1016/S0092-8674(00)81014-4
   Kunick C, 2004, BIOORG MED CHEM LETT, V14, P413, DOI 10.1016/j.bmcl.2003.10.062
   Lai KW, 2018, BIOORG MED CHEM LETT, V28, P15, DOI 10.1016/j.bmcl.2017.11.025
   Lamia KA, 2009, SCIENCE, V326, P437, DOI 10.1126/science.1172156
   Landgraf D, 2016, PLOS GENET, V12, DOI 10.1371/journal.pgen.1005882
   Lasko LM, 2017, NATURE, V550, P128, DOI 10.1038/nature24028
   Lawlor L, 2019, INT J ORAL SCI, V11, DOI 10.1038/s41368-019-0053-2
   Layton ME, 2011, ACS CHEM NEUROSCI, V2, P352, DOI 10.1021/cn200013d
   Lederer D, 2012, AM J HUM GENET, V90, P119, DOI 10.1016/j.ajhg.2011.11.021
   Lee HJ, 2019, J MED FOOD, V22, P833, DOI 10.1089/jmf.2018.4261
   Lee HM, 2011, P NATL ACAD SCI USA, V108, P16451, DOI 10.1073/pnas.1107178108
   Lee JW, 2015, CHEMMEDCHEM, V10, P1489, DOI 10.1002/cmdc.201500260
   Lee JW, 2011, ANGEW CHEM INT EDIT, V50, P10608, DOI 10.1002/anie.201103915
   Lee MG, 2006, CHEM BIOL, V13, P563, DOI 10.1016/j.chembiol.2006.05.004
   Lee Y, 2010, J CELL SCI, V123, P3547, DOI 10.1242/jcs.070300
   LeGates TA, 2014, NAT REV NEUROSCI, V15, P443, DOI 10.1038/nrn3743
   Leloup JC, 2011, IET SYST BIOL, V5, P44, DOI 10.1049/iet-syb.2009.0068
   Li J, 2019, MOLECULES, V24, DOI 10.3390/molecules24162916
   Li JZ, 2013, P NATL ACAD SCI USA, V110, P9950, DOI 10.1073/pnas.1305814110
   Li YY, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00669
   Lindberg PT, 2019, FRONT NEUROSCI-SWITZ, V13, DOI 10.3389/fnins.2019.01281
   Liu FG, 2019, J AGR FOOD CHEM, V67, P8735, DOI 10.1021/acs.jafc.9b02263
   Löscher W, 2012, NAT REV NEUROL, V8, P661, DOI 10.1038/nrneurol.2012.222
   Lovinger, 2020, ENDOCANNABINOIDS SLE, V13
   Silva NDLE, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00057
   Maes T, 2018, CANCER CELL, V33, P495, DOI 10.1016/j.ccell.2018.02.002
   Malhi GS, 2015, AUST NZ J PSYCHIAT, V49, P1087, DOI 10.1177/0004867415617657
   Marcheva B, 2010, NATURE, V466, P627, DOI 10.1038/nature09253
   Masri S, 2012, ANN NY ACAD SCI, V1264, P103, DOI 10.1111/j.1749-6632.2012.06649.x
   Maury E, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20071597
   McHill AW, 2017, AM J CLIN NUTR, V106, P1213, DOI 10.3945/ajcn.117.161588
   Mi YS, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201700440
   Mi YS, 2017, BBA-MOL BASIS DIS, V1863, P1575, DOI 10.1016/j.bbadis.2017.04.009
   Mikova O, 2001, EUR NEUROPSYCHOPHARM, V11, P203, DOI 10.1016/S0924-977X(01)00081-5
   Miller S, 2020, J MOL BIOL, V432, P3498, DOI 10.1016/j.jmb.2020.01.003
   Miller S, 2020, NAT CHEM BIOL, V16, P676, DOI 10.1038/s41589-020-0505-1
   Mimasu S, 2010, BIOCHEMISTRY-US, V49, P6494, DOI 10.1021/bi100299r
   Miranda J, 2013, BRIT J NUTR, V110, P1421, DOI 10.1017/S0007114513000755
   Mitsui S, 2001, GENE DEV, V15, P995, DOI 10.1101/gad.873501
   Moderie C, 2017, SLEEP MED, V34, P148, DOI 10.1016/j.sleep.2017.03.021
   Mohammad HP, 2015, CANCER CELL, V28, P57, DOI 10.1016/j.ccell.2015.06.002
   Monteiro R, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/289645
   Mottamal M, 2015, MOLECULES, V20, P3898, DOI 10.3390/molecules20033898
   Nagai N, 2019, INVEST OPHTH VIS SCI, V60, P3786, DOI 10.1167/iovs.19-27195
   Nagarajan N, 2001, NEUROPHARMACOLOGY, V41, P650, DOI 10.1016/S0028-3908(01)00133-2
   Nahm SS, 2005, J NEUROSCI, V25, P9304, DOI 10.1523/jneurosci.2733-05.2005
   Nam HJ, 2014, MOL CELL, V53, P791, DOI 10.1016/j.molcel.2014.01.028
   Nelson CS, 1996, NEUROREPORT, V7, P717, DOI 10.1097/00001756-199602290-00009
   Ng SB, 2010, NAT GENET, V42, P790, DOI 10.1038/ng.646
   Nomura K, 2003, J NEUROSCI RES, V72, P384, DOI 10.1002/jnr.10581
   Obrietan K, 1998, NAT NEUROSCI, V1, P693, DOI 10.1038/3695
   Oike H, 2015, BIOCHEM BIOPH RES CO, V465, P556, DOI 10.1016/j.bbrc.2015.08.059
   Oishi K, 2020, NUTRITION, V75-76, DOI [10.1016/j.nut.2020.110751, 10.1016/j.nut.2020-110751]
   Oishi Katsutaka, 2017, Biochem Biophys Rep, V9, P232, DOI 10.1016/j.bbrep.2016.12.008
   Okada Y, 2020, MOL BIOL REP, V47, P1021, DOI 10.1007/s11033-019-05194-8
   Ono A, 2019, PLANT CELL PHYSIOL, V60, P2360, DOI 10.1093/pcp/pcz183
   Orozco-Solis R, 2017, BIOL PSYCHIAT, V82, P351, DOI 10.1016/j.biopsych.2017.02.1176
   Oshima T, 2019, SCI ADV, V5, DOI 10.1126/sciadv.aau9060
   Oshima T, 2015, ANGEW CHEM INT EDIT, V54, P7193, DOI 10.1002/anie.201502942
   Pagano MA, 2004, BIOCHEM BIOPH RES CO, V321, P1040, DOI 10.1016/j.bbrc.2004.07.067
   Pandarakalam JP, 2018, PSYCHIAT DANUB, V30, P273, DOI 10.24869/psyd.2018.273
   Parenti MD, 2014, J MED CHEM, V57, P4796, DOI 10.1021/jm500487d
   Pariollaud M, 2018, J CLIN INVEST, V128, P2281, DOI 10.1172/JCI93910
   Park I, 2014, ENDOCRINOL METAB, V29, P379, DOI 10.3803/EnM.2014.29.3.379
   Patel N, 2020, ELIFE, V9, DOI 10.7554/eLife.53779
   Patil Ashwini, 2019, Ind Psychiatry J, V28, P68, DOI 10.4103/ipj.ipj_93_18
   Peek CB, 2012, TRENDS ENDOCRIN MET, V23, P312, DOI 10.1016/j.tem.2012.02.003
   Pepper I, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00311
   Pérez-Martínez P, 2017, NUTR REV, V75, P307, DOI 10.1093/nutrit/nux014
   Perez-Pinzon M.A., 2018, BRAIN SIRT1 MEDIATES, P9
   Pévet P, 2016, EXPERT OPIN THER TAR, V20, P1209, DOI 10.1080/14728222.2016.1179284
   Picaud S, 2015, CANCER RES, V75, P5106, DOI 10.1158/0008-5472.CAN-15-0236
   Pifferi F, 2011, J BIOL RHYTHM, V26, P271, DOI 10.1177/0748730411401788
   Pilotto S, 2016, HUM MOL GENET, V25, P2578, DOI 10.1093/hmg/ddw120
   Pitsillou E, 2020, MOL BIOL REP, V47, P753, DOI 10.1007/s11033-019-05129-3
   Plautz JD, 1997, SCIENCE, V278, P1632, DOI 10.1126/science.278.5343.1632
   Potter GDM, 2016, ENDOCR REV, V37, P584, DOI 10.1210/er.2016-1083
   Pourhanifeh MH, 2020, DIABETOL METAB SYNDR, V12, DOI 10.1186/s13098-020-00537-z
   Preitner N, 2002, CELL, V110, P251, DOI 10.1016/S0092-8674(02)00825-5
   Pulimeno P, 2013, DIABETOLOGIA, V56, P497, DOI 10.1007/s00125-012-2779-7
   Qi GY, 2018, FOOD CHEM TOXICOL, V122, P181, DOI 10.1016/j.fct.2018.10.031
   Qi GY, 2018, BBA-MOL CELL BIOL L, V1863, P549, DOI 10.1016/j.bbalip.2018.02.009
   Qi GY, 2017, FOOD CHEM TOXICOL, V110, P189, DOI 10.1016/j.fct.2017.10.031
   Qi GY, 2017, J FUNCT FOODS, V34, P168, DOI 10.1016/j.jff.2017.04.031
   Qian J, 2018, SLEEP, V41, pA17, DOI 10.1093/sleep/zsy061.040
   Qian JY, 2019, INT J OBESITY, V43, P1644, DOI 10.1038/s41366-018-0208-9
   Qiu PY, 2019, NATL SCI REV, V6, P87, DOI 10.1093/nsr/nwz002
   Rai R, 2019, J CELL MOL MED, V23, P3026, DOI 10.1111/jcmm.14162
   RALPH MR, 1988, SCIENCE, V241, P1225, DOI 10.1126/science.3413487
   Rensing L, 2001, CHRONOBIOL INT, V18, P329, DOI 10.1081/CBI-100103961
   Reutrakul S, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-58205-1
   Ribas-Latre A, 2015, J NUTR BIOCHEM, V26, P112, DOI 10.1016/j.jnutbio.2014.09.006
   Ring DB, 2003, DIABETES, V52, P588, DOI 10.2337/diabetes.52.3.588
   Röder PV, 2016, EXP MOL MED, V48, DOI 10.1038/emm.2016.6
   Romero FA, 2017, J MED CHEM, V60, P9162, DOI 10.1021/acs.jmedchem.7b00796
   Ruzzene M, 2002, BIOCHEM J, V364, P41, DOI 10.1042/bj3640041
   Saini C, 2016, DIABETES OBES METAB, V18, P355, DOI 10.1111/dom.12616
   Saini R, 2019, BMC BIOL, V17, DOI 10.1186/s12915-018-0623-3
   Sakane C, 2014, BIOCHEM BIOPH RES CO, V444, P24, DOI 10.1016/j.bbrc.2013.12.144
   Sartori L, 2017, J MED CHEM, V60, P1673, DOI 10.1021/acs.jmedchem.6b01018
   Sasaki H, 2016, CHRONOBIOL INT, V33, P849, DOI 10.3109/07420528.2016.1171775
   Seifalian Amelia, 2019, J Lifestyle Med, V9, P1, DOI 10.15280/jlm.2019.9.1.1
   Selfridge JM, 2016, DRUGS, V76, P1507, DOI 10.1007/s40265-016-0646-4
   Shearman LP, 1997, NEURON, V19, P1261, DOI 10.1016/S0896-6273(00)80417-1
   Shearman LP, 2000, SCIENCE, V288, P1013, DOI 10.1126/science.288.5468.1013
   Shen WT, 2020, THERANOSTICS, V10, P4466, DOI 10.7150/thno.42478
   Shi GS, 2016, CELL REP, V14, P823, DOI 10.1016/j.celrep.2015.12.076
   Shi YJ, 2004, CELL, V119, P941, DOI 10.1016/j.cell.2004.12.012
   Shim HS, 2007, EMBO REP, V8, P366, DOI 10.1038/sj.embor.7400920
   Shinozaki A, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0170904
   Shirogane T, 2005, J BIOL CHEM, V280, P26863, DOI 10.1074/jbc.M502862200
   Siddiqui-Jain A, 2010, CANCER RES, V70, P10288, DOI 10.1158/0008-5472.CAN-10-1893
   Sládek M, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00361
   Smith JK, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00574
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Solt LA, 2015, ENDOCRINOLOGY, V156, P869, DOI 10.1210/en.2014-1677
   Solt LA, 2012, ACS CHEM BIOL, V7, P1515, DOI 10.1021/cb3002649
   Solt LA, 2012, NATURE, V485, P62, DOI 10.1038/nature11030
   Son GH, 2008, P NATL ACAD SCI USA, V105, P20970, DOI 10.1073/pnas.0806962106
   Song Y, 2020, CELL REP, V30, P2699, DOI 10.1016/j.celrep.2020.01.091
   Stamenkovic JA, 2012, METABOLISM, V61, P978, DOI 10.1016/j.metabol.2011.11.013
   Stehlin C, 2001, EMBO J, V20, P5822, DOI 10.1093/emboj/20.21.5822
   Stehlin-Gaon C, 2003, NAT STRUCT BIOL, V10, P820, DOI 10.1038/nsb979
   Stein RM, 2020, NATURE, V579, P609, DOI 10.1038/s41586-020-2027-0
   STEINER M, 1987, PROG NEURO-PSYCHOPH, V11, P267
   Stenvers DJ, 2019, NAT REV ENDOCRINOL, V15, P75, DOI 10.1038/s41574-018-0122-1
   STEPHAN FK, 1972, P NATL ACAD SCI USA, V69, P1583, DOI 10.1073/pnas.69.6.1583
   Stroebel D, 2016, MOL PHARMACOL, V89, P541, DOI 10.1124/mol.115.103036
   Sun LJ, 2015, BIOCHEM BIOPH RES CO, V458, P86, DOI 10.1016/j.bbrc.2015.01.072
   Sun Z, 2011, COLD SH Q B, V76, P49, DOI 10.1101/sqb.2011.76.011494
   Sun Z, 2012, NAT MED, V18, P934, DOI 10.1038/nm.2744
   Sun ZS, 1997, CELL, V90, P1003, DOI 10.1016/S0092-8674(00)80366-9
   Suryanarayanan V, 2018, INT J BIOL MACROMOL, V120, P823, DOI 10.1016/j.ijbiomac.2018.08.052
   Takahashi JS, 2017, NAT REV GENET, V18, P164, DOI 10.1038/nrg.2016.150
   Tan XT, 2019, J AGR FOOD CHEM, V67, P8510, DOI 10.1021/acs.jafc.9b03368
   Tei H, 1997, NATURE, V389, P512, DOI 10.1038/39086
   THOMAS D, 2009, J ENDOCRINOL, V200, P3
   Toffolo E, 2014, J NEUROCHEM, V128, P603, DOI 10.1111/jnc.12457
   Toh KL, 2001, SCIENCE, V291, P1040, DOI 10.1126/science.1057499
   Touitou Y, 2017, LIFE SCI, V173, P94, DOI 10.1016/j.lfs.2017.02.008
   Trapp J, 2007, CHEMMEDCHEM, V2, P1419, DOI 10.1002/cmdc.200700003
   Trump RP, 2013, J MED CHEM, V56, P4729, DOI 10.1021/jm400458q
   Tsuneki H, 2018, PHARMACOL THERAPEUT, V186, P25, DOI 10.1016/j.pharmthera.2017.12.010
   Uchida S, 2018, PSYCHIAT CLIN NEUROS, V72, P212, DOI 10.1111/pcn.12621
   van der Horst GTJ, 1999, NATURE, V398, P627, DOI 10.1038/19323
   van der Vinne V, 2020, J PINEAL RES, V69, DOI 10.1111/jpi.12654
   Vanselow K, 2006, GENE DEV, V20, P2660, DOI 10.1101/gad.397006
   Vasilatos SN, 2013, CARCINOGENESIS, V34, P1196, DOI 10.1093/carcin/bgt033
   Vieira E, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0069939
   Vincek AS, 2018, MOLECULES, V23, DOI 10.3390/molecules23081930
   VITATERNA MH, 1994, SCIENCE, V264, P719, DOI 10.1126/science.8171325
   Vitaterna MH, 1999, P NATL ACAD SCI USA, V96, P12114, DOI 10.1073/pnas.96.21.12114
   Vizi ES., 1996, CNS Drug Rev, V2, P91
   Walton KM, 2009, J PHARMACOL EXP THER, V330, P430, DOI 10.1124/jpet.109.151415
   Wang YJ, 2010, ACS CHEM BIOL, V5, P1029, DOI 10.1021/cb100223d
   Wang YJ, 2010, BBA-MOL CELL BIOL L, V1801, P917, DOI 10.1016/j.bbalip.2010.02.012
   Wang YJ, 2010, J BIOL CHEM, V285, P5013, DOI 10.1074/jbc.M109.080614
   Ward EM, 2019, LANCET ONCOL, V20, P1058, DOI 10.1016/S1470-2045(19)30455-3
   Watson PJ, 2012, NATURE, V481, P335, DOI 10.1038/nature10728
   Wei H, 2020, PSYCHONEUROENDOCRINO, V113, DOI 10.1016/j.psyneuen.2019.104551
   Wheaton KL, 2018, J BIOL RHYTHM, V33, P497, DOI 10.1177/0748730418791713
   Wilking M, 2013, ANTIOXID REDOX SIGN, V19, P192, DOI 10.1089/ars.2012.4889
   WILLIAMS K, 1993, MOL PHARMACOL, V44, P851
   World Health Organisation, 2016, CAUS SPEC MORT 2000
   World Health Organisation, 2016, DIS BURD 2000 2016
   World Health Organization, 2017, WHOMSDMER20172
   Wu FR, 2016, J MED CHEM, V59, P253, DOI 10.1021/acs.jmedchem.5b01361
   Wu G, 2003, MOL CELL, V11, P1445, DOI 10.1016/S1097-2765(03)00234-X
   Wyse CA, 2017, ANN MED, V49, P411, DOI 10.1080/07853890.2017.1292045
   Xie YL, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00682
   Xu T, 2011, J BIOL CHEM, V286, P22707, DOI 10.1074/jbc.C111.250407
   Xu Y, 2007, CELL, V128, P59, DOI 10.1016/j.cell.2006.11.043
   Xu Y, 2005, NATURE, V434, P640, DOI 10.1038/nature03453
   Yamazaki S, 2000, SCIENCE, V288, P682, DOI 10.1126/science.288.5466.682
   Yang GJ, 2018, MOLECULES, V23, DOI 10.3390/molecules23123194
   Yang MJ, 2007, BIOCHEMISTRY-US, V46, P8058, DOI 10.1021/bi700664y
   Yap CS, 2020, GENE, V731, DOI 10.1016/j.gene.2020.144360
   Yasumoto Y, 2016, METABOLISM, V65, P714, DOI 10.1016/j.metabol.2016.02.003
   Ye JP, 2013, DIABETES, V62, P685, DOI 10.2337/db12-1354
   Yin L, 2005, MOL ENDOCRINOL, V19, P1452, DOI 10.1210/me.2005-0057
   Yoshitane H, 2019, COMMUN BIOL, V2, DOI 10.1038/s42003-019-0522-3
   You WJ, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-55654-1
   YUSUKE H, 2016, CURR MOL PHARMACOL, V9, P272
   Zhang JC, 2016, CURR NEUROPHARMACOL, V14, P721, DOI 10.2174/1570159X14666160119094646
   Zhang Y, 2019, J MED CHEM, V62, P4716, DOI 10.1021/acs.jmedchem.9b00327
   Zhao X, 2013, J MED CHEM, V56, P963, DOI 10.1021/jm301431y
   Zheng BH, 1999, NATURE, V400, P169, DOI 10.1038/22118
   Zheng YC, 2016, BIOORG CHEM, V69, P129, DOI 10.1016/j.bioorg.2016.10.004
   Zibetti C, 2010, J NEUROSCI, V30, P2521, DOI 10.1523/JNEUROSCI.5500-09.2010
   Zimmet P, 2019, J INTERN MED, V286, P181, DOI 10.1111/joim.12924
   Zimmet Paul Z, 2017, Clin Diabetes Endocrinol, V3, P1, DOI 10.1186/s40842-016-0039-3
   ZIMMET PZ, 1974, BMJ-BRIT MED J, V1, P485, DOI 10.1136/bmj.1.5906.485
   Zorumski CF, 2016, J NEUROSCI, V36, P11158, DOI 10.1523/JNEUROSCI.1547-16.2016
   Zylka MJ, 1998, NEURON, V20, P1103, DOI 10.1016/S0896-6273(00)80492-4
NR 324
TC 13
Z9 13
U1 4
U2 31
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JAN 15
PY 2021
VL 265
AR 118809
DI 10.1016/j.lfs.2020.118809
PG 16
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA PN4DK
UT WOS:000604430800062
PM 33249097
DA 2025-06-11
ER

PT J
AU Silhavy, J
   Mlejnek, P
   Simáková, M
   Malínská, H
   Marková, I
   Hüttl, M
   Miklánková, D
   Kazdová, L
   Vrbacky, M
   Pecinová, A
   Mrácek, T
   Pravenec, M
AF Silhavy, Jan
   Mlejnek, Petr
   Simakova, Miroslava
   Malinska, Hana
   Markova, Irena
   Huttl, Martina
   Miklankova, Denisa
   Kazdova, Ludmila
   Vrbacky, Marek
   Pecinova, Alena
   Mracek, Tomas
   Pravenec, Michal
TI Hypolipidemic Effects of Beetroot Juice in SHR-CRP and HHTg Rat Models
   of Metabolic Syndrome: Analysis of Hepatic Proteome
SO METABOLITES
LA English
DT Article
DE spontaneously hypertensive rat; hereditary hypertriglyceridemic rat;
   beetroot; lipids; proteomics; glycerophospholipid metabolism; mTOR
   signalling
ID BETA-VULGARIS L.; IDENTIFICATION; CHOLESTEROL; DEFICIENT; NITRATE;
   TARGET
AB Recently, red beetroot has attracted attention as a health-promoting functional food. Studies have shown that beetroot administration can reduce blood pressure and ameliorate parameters of glucose and lipid metabolism; however, mechanisms underlying these beneficial effects of beetroot are not yet fully understood. In the current study, we analysed the effects of beetroot on parameters of glucose and lipid metabolism in two models of metabolic syndrome: (i) transgenic spontaneously hypertensive rats expressing human C-reactive protein (SHR-CRP rats), and (ii) hereditary hypertriglyceridemic (HHTg) rats. Treatment with beetroot juice for 4 weeks was, in both models, associated with amelioration of oxidative stress, reduced circulating lipids, smaller visceral fat depots, and lower ectopic fat accumulation in the liver compared to the respective untreated controls. On the other hand, beetroot treatment had no significant effects on the sensitivity of the muscle and adipose tissue to insulin action in either model. Analyses of hepatic proteome revealed significantly deregulated proteins involved in glycerophospholipid metabolism, mTOR signalling, inflammation, and cytoskeleton rearrangement.
C1 [Silhavy, Jan; Mlejnek, Petr; Simakova, Miroslava; Vrbacky, Marek; Pecinova, Alena; Mracek, Tomas; Pravenec, Michal] Czech Acad Sci, Inst Physiol, Prague, Czech Republic.
   [Malinska, Hana; Markova, Irena; Huttl, Martina; Miklankova, Denisa; Kazdova, Ludmila] Inst Clin & Expt Med, Ctr Expt Med, Prague 14021, Czech Republic.
C3 Czech Academy of Sciences; Institute of Physiology of the Czech Academy
   of Sciences; Institute for Clinical & Experimental Medicine (IKEM)
RP Silhavy, J (corresponding author), Czech Acad Sci, Inst Physiol, Prague, Czech Republic.
EM jan.silhavy@fgu.cas.cz
RI Silhavy, Jan/B-5292-2014; Simakova, Miroslava/R-5367-2019; Mracek,
   Tomas/C-5003-2012; Mlejnek, Petr/C-2305-2012; Pravenec,
   Michal/B-1666-2012; Pecinova, Alena/A-8695-2010
OI Pravenec, Michal/0000-0001-9197-5871; Malinska,
   Hana/0000-0002-9076-3399; Kazdova, Ludmila/0000-0003-0563-0186; Markova,
   Irena/0000-0002-4331-7636; Pecinova, Alena/0000-0002-0204-7502
CR Abedimanesh N, 2021, NUTR METAB, V18, DOI 10.1186/s12986-021-00621-9
   Al-Dosari M, 2011, FARMACIA, V59, P669
   Al-Harbi LN, 2021, BIOLOGY-BASEL, V10, DOI 10.3390/biology10121306
   Albasher G, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9070261
   Archana Singh Archana Singh, 2015, Journal of Pharmacy and Nutrition Sciences, V5, P179, DOI 10.6000/1927-5951.2015.05.03.2
   Audrito V, 2020, FRONT ONCOL, V10, DOI 10.3389/fonc.2020.00358
   Caron A, 2017, MOL METAB, V6, P447, DOI 10.1016/j.molmet.2017.02.005
   Chen Y, 2015, ANN NUTR METAB, V66, P10, DOI 10.1159/000368661
   Coles LT, 2012, NUTR J, V11, DOI 10.1186/1475-2891-11-106
   Cortés VA, 2009, CELL METAB, V9, P165, DOI 10.1016/j.cmet.2009.01.002
   Cox J, 2014, MOL CELL PROTEOMICS, V13, P2513, DOI 10.1074/mcp.M113.031591
   Cox J, 2008, NAT BIOTECHNOL, V26, P1367, DOI 10.1038/nbt.1511
   Csaki LS, 2014, MOL METAB, V3, P145, DOI 10.1016/j.molmet.2013.11.008
   El Gamal AA, 2014, MEDIAT INFLAMM, V2014, DOI 10.1155/2014/983952
   Feitosa MF, 2013, ATHEROSCLEROSIS, V228, P175, DOI 10.1016/j.atherosclerosis.2013.01.038
   Förstermann U, 2012, EUR HEART J, V33, P829, DOI 10.1093/eurheartj/ehr304
   Garofalo RS, 2003, J CLIN INVEST, V112, P197, DOI 10.1172/JCI200316885
   Hadipour E, 2020, PHYTOTHER RES, V34, P1847, DOI 10.1002/ptr.6653
   Henderson CJ, 2003, J BIOL CHEM, V278, P13480, DOI 10.1074/jbc.M212087200
   Huang DW, 2009, NAT PROTOC, V4, P44, DOI 10.1038/nprot.2008.211
   Hüttl M, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222111513
   Inoue M, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0120289
   Jin Y, 2022, COMMUN BIOL, V5, DOI 10.1038/s42003-022-03251-w
   Johnston HE, 2022, ANAL CHEM, V94, P10320, DOI 10.1021/acs.analchem.1c04200
   Kerley CP, 2017, IRISH J MED SCI, V186, P895, DOI 10.1007/s11845-016-1551-2
   Kim Goon-Tae, 2020, J Lipid Atheroscler, V9, P291, DOI 10.12997/jla.2020.9.2.291
   Komatsu M, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-26882-8
   Liu GY, 2020, NAT REV MOL CELL BIO, V21, P183, DOI 10.1038/s41580-019-0199-y
   Lugo-Radillo A, 2012, NAT PRODUCT BIOPROSP, V2, P154, DOI 10.1007/s13659-012-0034-z
   Lutkewitte AJ, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10101386
   Malinska H, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0220377
   Mato JM, 2013, ANN HEPATOL, V12, P183, DOI 10.1016/S1665-2681(19)31355-9
   Milton-Laskibar I, 2021, FOODS, V10, DOI 10.3390/foods10061314
   Molotkov A, 2002, EUR J BIOCHEM, V269, P2607, DOI 10.1046/j.1432-1033.2002.02935.x
   Morris RC Jr, 2019, HYPERTENSION, V73, P1042, DOI 10.1161/HYPERTENSIONAHA.118.12234
   Péterfy M, 2001, NAT GENET, V27, P121, DOI 10.1038/83685
   Pravenec M, 2011, HYPERTENSION, V57, P731, DOI 10.1161/HYPERTENSIONAHA.110.164350
   Rabeh M. N., 2014, Pakistan Journal of Nutrition, V13, P500
   Rai P, 2017, P NATL ACAD SCI USA, V114, P12958, DOI 10.1073/pnas.1713292114
   Raish M, 2019, 3 BIOTECH, V9, DOI 10.1007/s13205-019-1677-9
   Ricoult SJH, 2013, EMBO REP, V14, P242, DOI 10.1038/embor.2013.5
   Romero SA, 2021, PHYTOTHER RES, V35, P6191, DOI 10.1002/ptr.7255
   Shetty AK, 2004, NUTR RES, V24, P373, DOI 10.1016/j.nutres.2003.11.010
   Singh J, 2022, FRONT CELL DEV BIOL, V10, DOI 10.3389/fcell.2022.893375
   Tian Y, 2006, J BIOL CHEM, V281, P28438, DOI 10.1074/jbc.M605861200
   Tyanova S, 2016, NAT METHODS, V13, P731, DOI [10.1038/NMETH.3901, 10.1038/nmeth.3901]
   van der Veen JN, 2017, BBA-BIOMEMBRANES, V1859, P1558, DOI 10.1016/j.bbamem.2017.04.006
   Versari D, 2009, DIABETES CARE, V32, pS314, DOI 10.2337/dc09-S330
   VRANA A, 1990, TRANSPLANT P, V22, P2579
   Vulic JJ, 2014, J FUNCT FOODS, V6, P168, DOI 10.1016/j.jff.2013.10.003
   Wang XY, 2020, HEPATOLOGY, V72, P1569, DOI 10.1002/hep.31161
   Watkins SM, 2003, J NUTR, V133, P3386, DOI 10.1093/jn/133.11.3386
   Webb AJ, 2008, HYPERTENSION, V51, P784, DOI 10.1161/HYPERTENSIONAHA.107.103523
   Wroblewska M, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-178
   Yamashita T., 2008, FOODS FOOD INGREDIEN, V213, P122
   Yuan MS, 2012, J BIOL CHEM, V287, P29579, DOI 10.1074/jbc.M112.386854
   Zicha J, 2006, PHYSIOL RES, V55, pS49, DOI 10.33549/physiolres.930000.55.S1.49
NR 57
TC 3
Z9 3
U1 0
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD FEB
PY 2023
VL 13
IS 2
AR 192
DI 10.3390/metabo13020192
PG 16
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 9J3JQ
UT WOS:000940087900001
PM 36837811
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kakarala, CL
   Hassan, M
   Belavadi, R
   Gudigopuram, SVR
   Raguthu, CC
   Gajjela, H
   Kela, I
   Sange, I
AF Kakarala, Chandra L.
   Hassan, Mohammad
   Belavadi, Rishab
   Gudigopuram, Sri Vallabh Reddy
   Raguthu, Ciri C.
   Gajjela, Harini
   Kela, Iljena
   Sange, Ibrahim
TI Beyond the Skin Plaques: Psoriasis and Its Cardiovascular Comorbidities
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE anti-tumor-necrosis factor-alpha; anti-il12/23; systemic inflammation;
   cardiovascular risk; cardiovascular disease; psoriasis
ID CORONARY-ARTERY-DISEASE; DIABETES-MELLITUS; IMMUNE-SYSTEM; ENDOTHELIAL
   DYSFUNCTION; METABOLIC SYNDROME; VASCULAR-DISEASES; OXIDATIVE STRESS;
   INCREASED RISK; HYPERTENSION; INFLAMMATION
AB Psoriasis, a widely prevalent chronic disease of the skin and joints, has long been associated with farreaching systemic ramifications and decreased quality of life. However, psoriasis is largely underdiagnosed and insufficiently treated. Classical risk factors predisposing to cardiovascular diseases, such as hypertension, diabetes, metabolic syndrome, and dyslipidemia, have been noted in patients with mild and severe psoriasis. Furthermore, the magnitude of the cardiovascular comorbidity and the need to screen for risk factors has often been ignored while considering the management options for psoriasis. This article has reviewed the cardiovascular implications of psoriasis from the shared pathogenesis behind these two diseases to the increased incidence of cardiovascular events, such as myocardial infarction, stroke, and other causes of vascular mortality. Additionally, the therapeutic targets of common inflammatory pathways, such as those involving tumor necrosis factor alpha (TNF-alpha), interleukin-12/interleukin-23 (IL-12/IL-23), and helper T cells 17 (Th17), have been discussed with an emphasis on their efficacy in controlling psoriasis and its cardiovascular consequences.
C1 [Kakarala, Chandra L.] Jawaharlal Inst Postgrad Med Educ & Res JIPMER, Internal Med, Pondicherry, India.
   [Hassan, Mohammad] Mohi Ud Din Islamic Med Coll, Internal Med, Mirpur, Pakistan.
   [Belavadi, Rishab] Jawaharlal Inst Postgrad Med Educ & Res JIPMER, Surg, Pondicherry, India.
   [Gudigopuram, Sri Vallabh Reddy] Our Lady Fatima Univ, Coll Med, Res, Hyderabad, India.
   [Raguthu, Ciri C.] Tianjin Med Univ, Res, Tianjin, Peoples R China.
   [Gajjela, Harini] Our Lady Fatima Univ, Coll Med, Res, Valenzuela, Poland.
   [Kela, Iljena] Jagiellonian Univ, Coll Med, Family Med, Krakow, Poland.
   [Sange, Ibrahim] Calif Inst Behav Neurosci & Psychol, Res, Fairfield, CT USA.
   [Sange, Ibrahim] KJ Somaiya Med Coll, Res, Mumbai, Maharashtra, India.
C3 Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research;
   Tianjin Medical University; Jagiellonian University; Collegium Medicum
   Jagiellonian University
RP Kakarala, CL (corresponding author), Jawaharlal Inst Postgrad Med Educ & Res JIPMER, Internal Med, Pondicherry, India.
EM kakarala.lalita@gmail.com
OI Kakarala, Chandra/0000-0003-0223-3118; Hassan,
   Mohammad/0000-0003-4973-7655
CR Afshin A, 2017, NEW ENGL J MED, V377, P13, DOI 10.1056/NEJMoa1614362
   Ahlehoff O, 2015, J EUR ACAD DERMATOL, V29, P1128, DOI 10.1111/jdv.12768
   Ahlehoff O, 2011, J INTERN MED, V270, P237, DOI 10.1111/j.1365-2796.2011.02368.x
   Amin M, 2020, ACTA DERM-VENEREOL, V100, P80, DOI 10.2340/00015555-3387
   Armstrong AW, 2011, J DERMATOL SCI, V63, P1, DOI 10.1016/j.jdermsci.2011.04.007
   Asha K, 2017, INDIAN J MED RES, V146, P708, DOI 10.4103/ijmr.IJMR_717_16
   Azfar RS, 2012, ARCH DERMATOL, V148, P995, DOI 10.1001/archdermatol.2012.1401
   Balak DMW, 2020, DERMATOLOGY THER, V10, P589, DOI 10.1007/s13555-020-00409-4
   Boehncke WH, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.00579
   Boehncke WH, 2015, LANCET, V386, P983, DOI 10.1016/S0140-6736(14)61909-7
   Caiazzo G, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01668
   Cheng X, 2008, CLIN IMMUNOL, V127, P89, DOI 10.1016/j.clim.2008.01.009
   Chularojanamontri L, 2019, INT J DERMATOL, V58, P593, DOI 10.1111/ijd.14349
   Cohen AD, 2010, ACTA DERM-VENEREOL, V90, P23, DOI 10.2340/00015555-0741
   Di Meglio P, 2014, CSH PERSPECT MED, V4, DOI 10.1101/cshperspect.a015354
   Elnabawi YA, 2019, CARDIOVASC RES, V115, P721, DOI 10.1093/cvr/cvz009
   Fernández-Armenteros JM, 2019, J EUR ACAD DERMATOL, V33, P128, DOI 10.1111/jdv.15159
   Flack JM, 2020, TRENDS CARDIOVAS MED, V30, P160, DOI 10.1016/j.tcm.2019.05.003
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   Fox CS, 2010, TRENDS CARDIOVAS MED, V20, P90, DOI 10.1016/j.tcm.2010.08.001
   Gelfand JM, 2006, JAMA-J AM MED ASSOC, V296, P1735, DOI 10.1001/jama.296.14.1735
   Gerdes S, 2010, DERMATOLOGY, V220, P38, DOI 10.1159/000265557
   Golden JB, 2013, CYTOKINE, V62, P195, DOI 10.1016/j.cyto.2013.03.013
   Gordon KB, 2012, J INVEST DERMATOL, V132, P304, DOI 10.1038/jid.2011.304
   Grundy SM, 1997, CIRCULATION, V95, P1, DOI 10.1161/01.CIR.95.1.1
   Hansson GK, 2006, ANNU REV PATHOL-MECH, V1, P297, DOI 10.1146/annurev.pathol.1.110304.100100
   Hansson GK, 2011, NAT IMMUNOL, V12, P204, DOI 10.1038/ni.2001
   Harden JL, 2015, J AUTOIMMUN, V64, P66, DOI 10.1016/j.jaut.2015.07.008
   Hart PH, 2011, NAT REV IMMUNOL, V11, P584, DOI 10.1038/nri3045
   Hawkes JE, 2018, J IMMUNOL, V201, P1605, DOI 10.4049/jimmunol.1800013
   Hjuler KF, 2016, JAMA DERMATOL, V152, P1114, DOI 10.1001/jamadermatol.2016.1984
   Hu SCS, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18102211
   Karbach S, 2014, ARTERIOSCL THROM VAS, V34, P2658, DOI 10.1161/ATVBAHA.114.304108
   Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213
   Kim JA, 2005, ARTERIOSCL THROM VAS, V25, P889, DOI 10.1161/01.ATV.0000164044.42910.6b
   Kim WB, 2017, CAN FAM PHYSICIAN, V63, P278
   Kothiwala SK, 2016, INDIAN J DERMATOL VE, V82, P510, DOI 10.4103/0378-6323.183638
   Krueger GG, 2000, J AM ACAD DERMATOL, V43, P281, DOI 10.1067/mjd.2000.106374
   Lan CCE, 2012, ACTA DERM-VENEREOL, V92, P349, DOI 10.2340/00015555-1283
   Lande R, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms6621
   Langley RGB, 2005, ANN RHEUM DIS, V64, P18, DOI 10.1136/ard.2004.033217
   Lee E, 2004, J Dermatolog Treat, V15, P8, DOI 10.1080/095466303100184473
   Lee MS, 2014, J AM ACAD DERMATOL, V70, P691, DOI 10.1016/j.jaad.2013.11.023
   Masson W, 2020, ADV THER, V37, P2017, DOI 10.1007/s12325-020-01346-6
   Masson W, 2013, MEDICINA-BUENOS AIRE, V73, P423
   Mease PJ, 2013, J AM ACAD DERMATOL, V69, P729, DOI 10.1016/j.jaad.2013.07.023
   Mehta NN, 2011, AM J MED, V124, DOI 10.1016/j.amjmed.2011.03.028
   Meng X, 2016, NAT REV CARDIOL, V13, P167, DOI 10.1038/nrcardio.2015.169
   Mills KT, 2016, CIRCULATION, V134, P441, DOI 10.1161/CIRCULATIONAHA.115.018912
   Montalescot G, 2013, EUR HEART J, V34, P2949, DOI 10.1093/eurheartj/eht296
   Myles Paul S, 2014, J Extra Corpor Technol, V46, P23
   Naldi L, 2016, PSORIASIS-TARGETS TH, V6, P65, DOI 10.2147/PTT.S85189
   Neimann AL, 2006, J AM ACAD DERMATOL, V55, P829, DOI 10.1016/j.jaad.2006.08.040
   Nickoloff BJ, 1999, J CLIN INVEST, V104, P1161, DOI 10.1172/JCI8633
   Nussbaum L, 2021, BRIT J DERMATOL, V184, P14, DOI 10.1111/bjd.19380
   Parisi R, 2020, BMJ-BRIT MED J, V369, DOI 10.1136/bmj.m1590
   Parisi R, 2015, J INVEST DERMATOL, V135, P2189, DOI 10.1038/jid.2015.87
   Petersmann A, 2019, EXP CLIN ENDOCR DIAB, V127, pS1, DOI 10.1055/a-1018-9078
   Piepoli Massimo F, 2016, Rev Esp Cardiol (Engl Ed), V69, P939, DOI 10.1016/j.rec.2016.09.009
   Pitts Stephen R, 2008, Natl Health Stat Report, P1
   Playford MP, 2019, ATHEROSCLEROSIS, V289, P44, DOI 10.1016/j.atherosclerosis.2019.08.006
   Prodanovich S, 2009, ARCH DERMATOL, V145, P700, DOI 10.1001/archdermatol.2009.94
   Prodanowich S, 2005, J AM ACAD DERMATOL, V52, P262, DOI 10.1016/j.jaad.2004.06.017
   Qureshi AA, 2009, ARCH DERMATOL, V145, P379, DOI 10.1001/archdermatol.2009.48
   Raaby L, 2017, ACTA DERM-VENEREOL, V97, P426, DOI 10.2340/00015555-2599
   Rapsomaniki E, 2014, LANCET, V383, P1899, DOI 10.1016/S0140-6736(14)60685-1
   Rendon A, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20061475
   Ryan C, 2010, J AM ACAD DERMATOL, V63, P949, DOI 10.1016/j.jaad.2010.02.062
   Sagoo GS, 2004, J INVEST DERMATOL, V122, P1401, DOI 10.1111/j.0022-202X.2004.22607.x
   Sajja AP, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01234
   Sheikh UA, 2020, AM J TROP MED HYG, V103, P206, DOI 10.4269/ajtmh.19-0646
   Soehnlein O, 2012, CIRC RES, V110, P875, DOI 10.1161/CIRCRESAHA.111.257535
   Sontheimer DL, 2006, AM FAM PHYSICIAN, V73, P1971
   Späh F, 2008, BRIT J DERMATOL, V159, P10, DOI 10.1111/j.1365-2133.2008.08780.x
   SWANBECK G, 1994, BRIT J DERMATOL, V131, P32, DOI 10.1111/j.1365-2133.1994.tb08454.x
   Tagami H, 1997, CLIN DERMATOL, V15, P677, DOI 10.1016/S0738-081X(97)00024-2
   Takeshita J, 2017, J AM ACAD DERMATOL, V76, P377, DOI 10.1016/j.jaad.2016.07.064
   ten Bergen LL, 2020, SCAND J IMMUNOL, V92, DOI 10.1111/sji.12946
   Thom T, 2006, CIRCULATION, V113, pE85, DOI 10.1161/CIRCULATIONAHA.105.171600
   Thygesen K, 2018, EUR HEART J, V39, P3757, DOI [10.1093/eurheartj/ehy655, 10.1093/eurheartj/ehy462, 10.1161/CIR.0000000000000617, 10.1016/j.jacc.2018.08.1038]
   Tsai MH, 2021, CLIN EPIDEMIOL, V13, P693, DOI 10.2147/CLEP.S305126
   VANZWIET.PA, 1973, NEW ENGL J MED, V288, P912
   Williams DM, 2018, RESP CARE, V63, P655, DOI 10.4187/respcare.06314
   Wu JJ, 2018, J EUR ACAD DERMATOL, V32, P1320, DOI 10.1111/jdv.14951
   Wu SW, 2014, JAMA DERMATOL, V150, P957, DOI 10.1001/jamadermatol.2013.9957
NR 85
TC 11
Z9 11
U1 0
U2 2
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD NOV 17
PY 2021
VL 13
IS 11
AR e19679
DI 10.7759/cureus.19679
PG 12
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA XD2FM
UT WOS:000722525700008
PM 34976467
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kalupahana, NS
   Claycombe, KJ
   Moustaid-Moussa, N
AF Kalupahana, Nishan S.
   Claycombe, Kate J.
   Moustaid-Moussa, Naima
TI (n-3) Fatty Acids Alleviate Adipose Tissue Inflammation and Insulin
   Resistance: Mechanistic Insights
SO ADVANCES IN NUTRITION
LA English
DT Review
AB Obesity is associated with the metabolic syndrome, a significant risk factor for developing type 2 diabetes and cardiovascular diseases. Chronic low-grade inflammation occurring in the adipose tissue of obese individuals is causally linked to the pathogenesis of insulin resistance and the metabolic syndrome. Although the exact trigger of this inflammatory process is unknown, adipose tissue hypoxia, endoplasmic reticular stress, and saturated fatty acid mediated activation of innate immune processes have been identified as important processes in these disorders. Furthermore, macrophages and T lymphocytes have important roles in orchestrating this immune process. Although energy restriction leading to weight loss is the primary dietary intervention to reverse these obesity-associated metabolic disorders, other interventions targeted at alleviating adipose tissue inflammation have not been explored in detail. In this regard, (n-3) PUFA of marine origin both prevent and reverse high-fat-diet induced adipose tissue inflammation and insulin resistance in rodents. We provide an update on the pathogenesis of adipose tissue inflammation and insulin resistance in obesity and discuss potential mechanisms by which (n-3) PUFA prevent and reverse these changes and the implications in human health. Adv. Nutr. 2: 304-316, 2011.
C1 [Kalupahana, Nishan S.; Moustaid-Moussa, Naima] Univ Tennessee, Obes Res Ctr, Knoxville, TN 37996 USA.
   [Kalupahana, Nishan S.; Moustaid-Moussa, Naima] Dept Anim Sci, Knoxville, TN 37996 USA.
   [Moustaid-Moussa, Naima] UT Extens Family & Consumer Sci Dept, Knoxville, TN 37996 USA.
   [Kalupahana, Nishan S.] Univ Peradeniya, Fac Med, Dept Physiol, Peradeniya 20400, Sri Lanka.
   [Claycombe, Kate J.] USDA ARS, Grand Forks Human Nutr Res Ctr, Grand Forks, ND 58201 USA.
C3 University of Tennessee System; University of Tennessee Knoxville;
   University of Tennessee System; University of Tennessee Knoxville; UT
   Institute of Agriculture; University of Tennessee System; University of
   Tennessee Knoxville; UT Institute of Agriculture; University of
   Peradeniya; United States Department of Agriculture (USDA)
RP Moustaid-Moussa, N (corresponding author), Univ Tennessee, Obes Res Ctr, Knoxville, TN 37996 USA.
EM moustaid@utk.edu
RI Kalupahana, Nishan/E-1913-2011; Moustaid-Moussa, Naima/B-9067-2014
FU National Institute of Food and Agriculture-National Research Initiative
   award [2005-35200-15224]; AHA Southeast Affiliate Predoctoral
   Fellowship; University of Tennessee (UT) Obesity Research Center; UT
   AgResearch; UT Extension
FX Supported by a National Institute of Food and Agriculture-National
   Research Initiative award (2005-35200-15224), an AHA Southeast Affiliate
   Predoctoral Fellowship, the University of Tennessee (UT) Obesity
   Research Center, UT AgResearch, and UT Extension.
CR Aarsetoey H, 2011, LIPIDS, V46, P151, DOI 10.1007/s11745-010-3511-3
   Aas V, 2006, J LIPID RES, V47, P366, DOI 10.1194/jlr.M500300-JLR200
   Abe M, 2008, ARTERIOSCL THROM VAS, V28, P871, DOI 10.1161/ATVBAHA.107.160663
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alexaki VI, 2009, J IMMUNOL, V183, P5948, DOI 10.4049/jimmunol.0901186
   Arkan MC, 2005, NAT MED, V11, P191, DOI 10.1038/nm1185
   Becker M, 2010, DIABETES, V59, P2898, DOI 10.2337/db10-0362
   Bekri S, 2006, GASTROENTEROLOGY, V131, P788, DOI 10.1053/j.gastro.2006.07.007
   Bès-Houtmann S, 2007, HISTOCHEM CELL BIOL, V127, P131, DOI 10.1007/s00418-006-0230-1
   Blasbalg TL, 2011, AM J CLIN NUTR, V93, P950, DOI 10.3945/ajcn.110.006643
   Boden G, 2008, DIABETES, V57, P2438, DOI 10.2337/db08-0604
   Brooks GC, 2010, AM J CARDIOL, V106, P56, DOI 10.1016/j.amjcard.2010.02.017
   Bruun JM, 2001, J CLIN ENDOCR METAB, V86, P1267, DOI 10.1210/jc.86.3.1267
   Cai DS, 2005, NAT MED, V11, P183, DOI 10.1038/nm1166
   Castan-Laurell I, 2008, EUR J ENDOCRINOL, V158, P905, DOI 10.1530/EJE-08-0039
   Chapkin RS, 2009, PROSTAG LEUKOTR ESS, V81, P187, DOI 10.1016/j.plefa.2009.05.010
   Chavey C, 2003, J BIOL CHEM, V278, P11888, DOI 10.1074/jbc.M209196200
   Cheng ZY, 2010, TRENDS ENDOCRIN MET, V21, P589, DOI 10.1016/j.tem.2010.06.005
   Christiansen T, 2005, INT J OBESITY, V29, P146, DOI 10.1038/sj.ijo.0802839
   Couet C, 1997, INT J OBESITY, V21, P637, DOI 10.1038/sj.ijo.0800451
   DeFuria J, 2009, J NUTR, V139, P1510, DOI 10.3945/jn.109.105155
   Dentin R, 2005, J CLIN INVEST, V115, P2843, DOI 10.1172/JCI25256
   Ehses JA, 2010, DIABETOLOGIA, V53, P1795, DOI 10.1007/s00125-010-1747-3
   Eiras S, 2010, CYTOKINE, V51, P207, DOI 10.1016/j.cyto.2010.05.009
   Emanuelli B, 2001, J BIOL CHEM, V276, P47944, DOI 10.1074/jbc.M104602200
   Feuerer M, 2009, NAT MED, V15, P930, DOI 10.1038/nm.2002
   Figueras M, 2011, OBESITY, V19, P362, DOI 10.1038/oby.2010.194
   Flachs P, 2006, DIABETOLOGIA, V49, P394, DOI 10.1007/s00125-005-0053-y
   Flachs P, 2005, DIABETOLOGIA, V48, P2365, DOI 10.1007/s00125-005-1944-7
   Flachs P, 2009, CLIN SCI, V116, P1, DOI 10.1042/CS20070456
   Friedman JM, 1998, NATURE, V395, P763, DOI 10.1038/27376
   Frydelund-Larsen L, 2007, AM J PHYSIOL-ENDOC M, V292, pE24, DOI 10.1152/ajpendo.00113.2006
   Gealekman O, 2008, AM J PHYSIOL-ENDOC M, V295, pE1056, DOI 10.1152/ajpendo.90345.2008
   Ghafoorunissa, 2005, J NUTR, V135, P2634, DOI 10.1093/jn/135.11.2634
   González-Périz A, 2009, FASEB J, V23, P1946, DOI 10.1096/fj.08-125674
   Gordon S, 2003, NAT REV IMMUNOL, V3, P23, DOI 10.1038/nri978
   Guo W, 2005, LIPIDS, V40, P815, DOI 10.1007/s11745-005-1443-8
   Gustafson B, AM J PHYSL ENDOCRINO, P21
   Harkins JM, 2004, J NUTR, V134, P2673, DOI 10.1093/jn/134.10.2673
   Hein GJ, 2010, AM J PHYSIOL-ENDOC M, V298, pE429, DOI 10.1152/ajpendo.00513.2009
   Hendrich S, 2010, ADV NUTR, V1, P3, DOI 10.3945/an.110.1003
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Hsueh HW., J Nutr
   Hu E, 1996, J BIOL CHEM, V271, P10697, DOI 10.1074/jbc.271.18.10697
   Ibrahim MM, 2010, OBES REV, V11, P11, DOI 10.1111/j.1467-789X.2009.00623.x
   Ide T, 2005, DIABETES, V54, P412, DOI 10.2337/diabetes.54.2.412
   Itoh M, 2007, ARTERIOSCL THROM VAS, V27, P1918, DOI 10.1161/ATVBAHA.106.136853
   Itoh Y, 2003, NATURE, V422, P173, DOI 10.1038/nature01478
   Jelenik T, 2010, DIABETES, V59, P2737, DOI 10.2337/db09-1716
   Jones BH, 1997, AM J PHYSIOL-REG I, V273, pR236, DOI 10.1152/ajpregu.1997.273.1.R236
   Juge-Aubry CE, 2004, J CLIN ENDOCR METAB, V89, P2652, DOI 10.1210/jc.2003-031219
   Kabir M, 2007, AM J CLIN NUTR, V86, P1670
   Kalupahana NS, 2011, OBESITY, V19, P245, DOI 10.1038/oby.2010.196
   Kalupahana NS, 2010, J NUTR, V140, P1915, DOI 10.3945/jn.110.125732
   Kalupahana NS, 2009, OBESITY, V17, pS58
   Kanda H, 2006, J CLIN INVEST, V116, P1494, DOI 10.1172/JCI26498
   Kennedy A, 2009, J NUTR, V139, P1, DOI 10.3945/jn.108.098269
   Kim S, 2002, J NUTR, V132, P1135, DOI 10.1093/jn/132.6.1135
   Kim S, 2000, J NUTR, V130, p3110S
   Kloeting N, 2007, CELL METAB, V6, P79, DOI 10.1016/j.cmet.2007.06.002
   Klöting N, 2006, BIOCHEM BIOPH RES CO, V339, P430, DOI 10.1016/j.bbrc.2005.11.039
   Kos K, 2007, AM J PHYSIOL-ENDOC M, V293, pE1335, DOI 10.1152/ajpendo.00333.2007
   Kos K, 2010, NAT REV ENDOCRINOL, V6, P225, DOI 10.1038/nrendo.2010.18
   Krebs JD, 2006, INT J OBESITY, V30, P1535, DOI 10.1038/sj.ijo.0803309
   Kris-Etherton PM, 2002, CIRCULATION, V106, P2747, DOI 10.1161/01.CIR.0000038493.65177.94
   Kuda O, 2009, DIABETOLOGIA, V52, P941, DOI 10.1007/s00125-009-1305-z
   Kusunoki M, 2003, METABOLISM, V52, P30, DOI 10.1053/meta.2003.50012
   LaRosa PC, 2006, PHYSIOL GENOMICS, V27, P282, DOI 10.1152/physiolgenomics.00076.2006
   Lindsay RS, 2002, LANCET, V360, P57, DOI 10.1016/S0140-6736(02)09335-2
   Lira FS, 2009, CYTOKINE, V45, P80, DOI 10.1016/j.cyto.2008.10.018
   Lorente-Cebrián S, 2009, CLIN SCI, V117, P243, DOI 10.1042/CS20090020
   Lumeng CN, 2007, J CLIN INVEST, V117, P175, DOI 10.1172/JCI29881
   Lumeng CN, 2009, NAT MED, V15, P846, DOI 10.1038/nm0809-846
   Lumeng CN, 2008, DIABETES, V57, P3239, DOI 10.2337/db08-0872
   Luo NL, 2010, DIABETES, V59, P791, DOI 10.2337/db09-1338
   Madsen L, 1999, LIPIDS, V34, P951, DOI 10.1007/s11745-999-0445-x
   Magné J, 2010, J NUTR BIOCHEM, V21, P550, DOI 10.1016/j.jnutbio.2009.03.004
   Mantovani A, 2004, TRENDS IMMUNOL, V25, P677, DOI 10.1016/j.it.2004.09.015
   Maquoi E, 2002, DIABETES, V51, P1093, DOI 10.2337/diabetes.51.4.1093
   Massiéra F, 2001, FASEB J, V15, P2727, DOI 10.1096/fj.01-0457fje
   McTernan CL, 2002, LANCET, V359, P46, DOI 10.1016/S0140-6736(02)07281-1
   Mohamed-Ali V, 2001, J CLIN ENDOCR METAB, V86, P5864, DOI 10.1210/jc.86.12.5864
   Morange PE, 1999, ARTERIOSCL THROM VAS, V19, P1361, DOI 10.1161/01.ATV.19.5.1361
   Mori TA, 1999, AM J CLIN NUTR, V70, P817
   Nakatani Y, 2005, J BIOL CHEM, V280, P847, DOI 10.1074/jbc.M411860200
   Neschen S, 2006, DIABETES, V55, P924, DOI 10.2337/diabetes.55.04.06.db05-0985
   Neschen S, 2002, AM J PHYSIOL-ENDOC M, V282, pE395, DOI 10.1152/ajpendo.00414.2001
   Neschen S, 2007, DIABETES, V56, P1034, DOI 10.2337/db06-1206
   Nettleton JA, 2005, J AM DIET ASSOC, V105, P428, DOI 10.1016/j.jada.2004.11.029
   Nishimura S, 2009, NAT MED, V15, P914, DOI 10.1038/nm.1964
   Oh DY, 2010, CELL, V142, P687, DOI 10.1016/j.cell.2010.07.041
   Olefsky JM, 2010, ANNU REV PHYSIOL, V72, P219, DOI 10.1146/annurev-physiol-021909-135846
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Pasarica M, 2009, DIABETES, V58, P718, DOI 10.2337/db08-1098
   Peeraully MR, 2004, AM J PHYSIOL-ENDOC M, V287, pE331, DOI 10.1152/ajpendo.00076.2004
   Pérez-Echarri N, 2008, EUR J NUTR, V47, P380, DOI 10.1007/s00394-008-0738-3
   Pérez-Echarri N, 2009, BRIT J NUTR, V101, P1059, DOI 10.1017/S0007114508048307
   Pettinelli P, 2009, BBA-MOL BASIS DIS, V1792, P1080, DOI 10.1016/j.bbadis.2009.08.015
   Poirier H, 2006, DIABETES, V55, P1634, DOI 10.2337/db06-0036
   Prieur X, 2011, DIABETES, V60, P797, DOI 10.2337/db10-0705
   Puglisi MJ, 2011, J NUTR BIOCHEM, V22, P101, DOI 10.1016/j.jnutbio.2010.07.003
   Rivellese AA, 1996, DIABETES CARE, V19, P1207, DOI 10.2337/diacare.19.11.1207
   Rui LY, 2002, J BIOL CHEM, V277, P42394, DOI 10.1074/jbc.C200444200
   RUSTAN AC, 1988, J LIPID RES, V29, P1417
   Ruzickova J, 2004, LIPIDS, V39, P1177, DOI 10.1007/s11745-004-1345-9
   Saraswathi V, 2007, J NUTR, V137, P1776, DOI 10.1093/jn/137.7.1776
   Sato C, 2011, DIABETES, V60, P189, DOI 10.2337/db09-1894
   Schenk S, 2008, J CLIN INVEST, V118, P2992, DOI 10.1172/JCI34260
   Schmitz-Peiffer C, 2010, DIABETES, V59, P2351, DOI 10.2337/db10-0912
   Schwab JM, 2007, NATURE, V447, P869, DOI 10.1038/nature05877
   Sekiya M, 2003, HEPATOLOGY, V38, P1529, DOI 10.1016/j.hep.2003.09.028
   Shen XH, 2004, J CHEM NEUROANAT, V28, P79, DOI 10.1016/j.jchemneu.2004.02.006
   Simopoulos AP., MOL NEUROBIOL
   Simopoulos AP, 2008, EXP BIOL MED, V233, P674, DOI 10.3181/0711-MR-311
   Sinha S, 2004, J BIOL CHEM, V279, P41294, DOI 10.1074/jbc.M406514200
   Skurk T, 2007, J CLIN ENDOCR METAB, V92, P1023, DOI 10.1210/jc.2006-1055
   Stefan N, 2008, ARCH INTERN MED, V168, P1609, DOI 10.1001/archinte.168.15.1609
   STORLIEN LH, 1987, SCIENCE, V237, P885, DOI 10.1126/science.3303333
   STORLIEN LH, 1991, DIABETES, V40, P280, DOI 10.2337/diabetes.40.2.280
   Stratford S, 2001, BIOCHEM J, V354, P359, DOI 10.1042/0264-6021:3540359
   Stumvoll M, 2005, LANCET, V365, P1333, DOI 10.1016/S0140-6736(05)61032-X
   Suchankova G, 2005, BIOCHEM BIOPH RES CO, V326, P851, DOI 10.1016/j.bbrc.2004.11.114
   Suganami T, 2007, BIOCHEM BIOPH RES CO, V354, P45, DOI 10.1016/j.bbrc.2006.12.190
   Surmi BK, 2010, AM J PHYSIOL-ENDOC M, V299, pE437, DOI 10.1152/ajpendo.00050.2010
   Svegliati-Baroni G, 2006, AM J PATHOL, V169, P846, DOI 10.2353/ajpath.2006.050953
   Takahashi K, 2003, J BIOL CHEM, V278, P46654, DOI 10.1074/jbc.M309895200
   Tang T, 2010, J BIOL CHEM, V285, P4637, DOI 10.1074/jbc.M109.068007
   Taniguchi CM, 2006, NAT REV MOL CELL BIO, V7, P85, DOI 10.1038/nrm1837
   Teran-Garcia M, 2007, BIOCHEM J, V402, P591, DOI 10.1042/BJ20061722
   Todoric J, 2006, DIABETOLOGIA, V49, P2109, DOI 10.1007/s00125-006-0300-x
   Ueki K, 2003, J BIOL CHEM, V278, P48453, DOI 10.1074/jbc.M305602200
   van Schothorst EM, 2009, BMC GENOMICS, V10, DOI 10.1186/1471-2164-10-110
   Vandanmagsar B, 2011, NAT MED, V17, P179, DOI 10.1038/nm.2279
   Varma V, 2008, DIABETES, V57, P432, DOI 10.2337/db07-0840
   Wang P, 2008, J CELL PHYSIOL, V216, P3, DOI 10.1002/jcp.21386
   Weisberg SP, 2006, J CLIN INVEST, V116, P115, DOI 10.1172/JCI24335
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Wensaas AJ, 2009, DIABETES, V58, P527, DOI 10.2337/db08-1043
   White PJ, 2010, DIABETES, V59, P3066, DOI 10.2337/db10-0054
   Winer S, 2009, NAT MED, V15, P921, DOI 10.1038/nm.2001
   Wood IS, 2005, BIOCHEM BIOPH RES CO, V337, P422, DOI 10.1016/j.bbrc.2005.09.068
   Wortman P, 2009, NUTR METAB, V6, DOI 10.1186/1743-7075-6-5
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yamauchi T, 2001, NAT MED, V7, P941, DOI 10.1038/90984
   Yang RZ, 2006, PLOS MED, V3, P884, DOI 10.1371/journal.pmed.0030287
   Yang RZ, 2006, AM J PHYSIOL-ENDOC M, V290, pE1253, DOI 10.1152/ajpendo.00572.2004
   Ye JP, 2007, AM J PHYSIOL-ENDOC M, V293, pE1118, DOI 10.1152/ajpendo.00435.2007
   Yvan-Charvet L, 2011, KIDNEY INT, V79, P162, DOI 10.1038/ki.2010.391
   Zeyda M, 2007, INT J OBESITY, V31, P1420, DOI 10.1038/sj.ijo.0803632
   Zeyda M, 2007, IMMUNOL LETT, V112, P61, DOI 10.1016/j.imlet.2007.07.003
   Zhang XM, 2011, DIABETES, V60, P486, DOI 10.2337/db10-0650
   Zhou HR, 2007, AM J PHYSIOL-ENDOC M, V293, pE1153, DOI 10.1152/ajpendo.00186.2007
   Zick Yehiel, 2005, Sci STKE, V2005, ppe4, DOI 10.1126/stke.2682005pe4
NR 155
TC 230
Z9 256
U1 2
U2 43
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 2161-8313
EI 2156-5376
J9 ADV NUTR
JI Adv. Nutr.
PD JUL
PY 2011
VL 2
IS 4
BP 304
EP 316
DI 10.3945/an.111.000505
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA V27BT
UT WOS:000208589400002
PM 22332072
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Hijová, E
AF Hijova, Emilia
TI Synbiotic Supplements in the Prevention of Obesity and Obesity-Related
   Diseases
SO METABOLITES
LA English
DT Review
DE obesity; synbiotics; gut microbiota; type 2 diabetes mellitus; metabolic
   syndrome
ID GUT MICROBIOTA; METABOLIC SYNDROME; DIABETIC-PATIENTS; LIPID PROFILES;
   DOUBLE-BLIND; INSULIN METABOLISM; OXIDATIVE STRESS; RISK-FACTORS;
   BODY-WEIGHT; PROBIOTICS
AB Obesity and being overweight have reached incredible proportions worldwide and are one of the most common human health problems. The causes of obesity are multifactorial, including a complex interplay among genes, metabolism, diet, physical activity, and the environment. The intestinal microbiota has the ability to affect the host physiology for both benefit and damage, either directly or through microbial metabolites. The aim of this review is to discuss the mechanisms by which the intestinal microbiota could act as a key modifier of obesity and related metabolic abnormalities. The synbiotic components provide an optimal target for modulation of the intestinal microbiota and help reshape the metabolic profile in obese people. The development of novel functional foods containing synbiotic ingredients may present a support in the prevention of obesity as one of the risk factors for chronic diseases. Knowledge of the synbiotic mechanisms of action and the use of new functional foods supplemented with probiotics and prebiotics will facilitate the clinical application and development of individual health care strategies.
C1 [Hijova, Emilia] Pavol Jozef Safarik Univ, Ctr Clin & Preclin Res MEDIPARK, Dept Expt Med, Fac Med, Kosice 04011, Slovakia.
C3 University of Pavol Jozef Safarik Kosice
RP Hijová, E (corresponding author), Pavol Jozef Safarik Univ, Ctr Clin & Preclin Res MEDIPARK, Dept Expt Med, Fac Med, Kosice 04011, Slovakia.
EM emilia.hijova@upjs.sk
OI Hijova, Emilia/0000-0002-8259-373X
FU Operational Program Integrated Infrastructure within the project:
   Functional Foods for Healthy Life [ITMS 2014+ 313012T288]; European
   Regional Development Fund; Demand-driven research for sustainable and
   innovative food, Drive4SIFood [313011V336]
FX This work was supported by the Operational Program Integrated
   Infrastructure within the project: Functional Foods for Healthy Life
   with ITMS 2014+ 313012T288 and Demand-driven research for sustainable
   and innovative food, Drive4SIFood 313011V336, co-financed by the
   European Regional Development Fund.
CR Abenavoli L, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112690
   Al-Assal K., 2018, Clinical Nutrition Experimental, V20, P60, DOI 10.1016/j.yclnex.2018.03.001
   Alemán JO, 2018, J TRANSL MED, V16, DOI 10.1186/s12967-018-1619-z
   Amar J, 2011, EMBO MOL MED, V3, P559, DOI 10.1002/emmm.201100159
   Angelino D, 2019, J NUTR, V149, P1714, DOI 10.1093/jn/nxz071
   Anggeraini AS, 2021, ANN MED SURG, V68, DOI 10.1016/j.amsu.2021.102548
   [Anonymous], OB OV
   Asemi Z, 2014, CLIN NUTR, V33, P198, DOI 10.1016/j.clnu.2013.05.015
   Asemi Z, 2013, ANN NUTR METAB, V63, P1, DOI 10.1159/000349922
   Bäckhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Bengmark S, 2005, GASTROENTEROL CLIN N, V34, P413, DOI 10.1016/j.gtc.2005.05.002
   Blaak EE, 2020, BENEF MICROBES, V11, P411, DOI 10.3920/BM2020.0057
   Bray GA, 2017, OBES REV, V18, P715, DOI 10.1111/obr.12551
   Brusaferro A, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111613
   Cencic A, 2010, NUTRIENTS, V2, P611, DOI 10.3390/nu2060611
   Cerdó T, 2019, NUTRIENTS, V11, DOI 10.3390/nu11030635
   Chambers ES, 2015, GUT, V64, P1744, DOI 10.1136/gutjnl-2014-307913
   Chopyk DM, 2020, GASTROENTEROLOGY, V159, P849, DOI 10.1053/j.gastro.2020.04.077
   Cicero AFG, 2021, EUR J NUTR, V60, P655, DOI 10.1007/s00394-020-02271-8
   Coppola S, 2021, MOLECULES, V26, DOI 10.3390/molecules26030682
   Cunningham AL, 2021, LIPIDS HEALTH DIS, V20, DOI 10.1186/s12944-021-01491-z
   Dang D, 2013, J INT MED RES, V41, P1426, DOI 10.1177/0300060513493692
   Dao MC, 2016, GUT, V65, P426, DOI 10.1136/gutjnl-2014-308778
   Eslamparast T, 2014, BRIT J NUTR, V112, P438, DOI 10.1017/S0007114514000919
   Everard A, 2013, BEST PRACT RES CL GA, V27, P73, DOI 10.1016/j.bpg.2013.03.007
   Feng WW, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01354
   Ferrarese R, 2018, EUR REV MED PHARMACO, V22, P7588, DOI 10.26355/eurrev_201811_16301
   Gao RY, 2018, OBESITY, V26, P351, DOI 10.1002/oby.22088
   Ghafouri A, 2019, DIABETOL METAB SYNDR, V11, DOI 10.1186/s13098-019-0496-9
   GIBSON GR, 1995, J NUTR, V125, P1401, DOI 10.1093/jn/125.6.1401
   Gourbeyre P, 2011, J LEUKOCYTE BIOL, V89, P685, DOI 10.1189/jlb.1109753
   Green M, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21082890
   Hadi A, 2019, COMPLEMENT THER MED, V47, DOI 10.1016/j.ctim.2019.102216
   Haghighat N, 2019, PROBIOTICS ANTIMICRO, V11, P1210, DOI 10.1007/s12602-018-9477-9
   Hibberd AA, 2019, BENEF MICROBES, V10, P121, DOI [10.3920/BM2018.0028, 10.3920/bm2018.0028]
   Hijova E, 2007, BRATISL MED J, V108, P354
   Hijova E, 2019, BRATISL MED J, V120, P807, DOI 10.4149/BLL_2019_134
   Hippe B, 2016, BENEF MICROBES, V7, P511, DOI 10.3920/BM2015.0075
   Ipar N, 2015, BENEF MICROBES, V6, P775, DOI 10.3920/BM2015.0011
   Isolauri E, 2017, NESTLE NUTR WORKS SE, V88, P95, DOI 10.1159/000455217
   Jiang ZL, 2020, BMC MED, V18, DOI 10.1186/s12916-020-01842-0
   Sáez-Lara MJ, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17060928
   Kassaian N, 2020, NUTRITION, V79-80, DOI 10.1016/j.nut.2020.110854
   Kassaian N, 2019, FUNCT FOODS HEALTH D, V9, P494, DOI 10.31989/ffhd.v9i7.617
   Kassaian N, 2019, DIABETES METAB SYND, V13, P2991, DOI 10.1016/j.dsx.2018.07.016
   Kassaian N, 2018, ACTA DIABETOL, V55, P1019, DOI 10.1007/s00592-018-1175-2
   Kim B, 2019, J OBES METAB SYNDR, V28, P216, DOI 10.7570/jomes.2019.28.4.216
   Kobyliak N, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0067-0
   Kvakova M, 2021, FOODS, V10, DOI 10.3390/foods10061297
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Liong MT, 2007, BRIT J NUTR, V98, P736, DOI 10.1017/S0007114507747803
   Manigandan T., 2012, Biomedical & Pharmacology Journal, V5, P295
   Markowiak P, 2017, NUTRIENTS, V9, DOI 10.3390/nu9091021
   Mirmiranpour H, 2020, J DIABETES METAB DIS, V19, P53, DOI 10.1007/s40200-019-00474-3
   Moran-Ramos S, 2017, ARCH MED RES, V48, P735, DOI 10.1016/j.arcmed.2017.11.003
   Moroti C, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-29
   Muccioli GG, 2010, MOL SYST BIOL, V6, DOI 10.1038/msb.2010.46
   Nash AK, 2017, MICROBIOME, V5, DOI 10.1186/s40168-017-0373-4
   Núñez-Sánchez MA, 2021, CURR OPIN FOOD SCI, V41, P60, DOI 10.1016/j.cofs.2021.02.014
   OECD/European Observatory on Health Systems and Policies, 2019, SLOVENSKO ZDRAVOTN P, DOI [10.1787/9789264285408-sk, DOI 10.1787/9789264285408-SK]
   Olas B, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21249737
   Olveira G, 2016, ENDOCRINOL NUTR, V63, P482, DOI 10.1016/j.endonu.2016.07.006
   Pandey KR, 2015, J FOOD SCI TECH MYS, V52, P7577, DOI 10.1007/s13197-015-1921-1
   Panesar P.S., 2009, SYNBIOTICS POTENTIAL, DOI [10.1136/gut.2005.074971, DOI 10.1136/GUT.2005.074971]
   Parastouei K, 2022, BMJ MILITARY HEALTH, V168, P362, DOI 10.1136/bmjmilitary-2020-001459
   Rabiei S, 2019, J DIET SUPPL, V16, P294, DOI 10.1080/19390211.2018.1455788
   Rabiei Samira, 2015, Med J Islam Repub Iran, V29, P213
   Rafter J, 2007, AM J CLIN NUTR, V85, P488, DOI 10.1093/ajcn/85.2.488
   Remely M, 2015, BENEF MICROBES, V6, P431, DOI 10.3920/BM2014.0104
   Ridaura VK, 2013, SCIENCE, V341, P1079, DOI 10.1126/science.1241214
   Riedel S, 2022, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.833544
   Safavi M, 2013, INT J FOOD SCI NUTR, V64, P687, DOI 10.3109/09637486.2013.775224
   Sanchez M, 2014, BRIT J NUTR, V111, P1507, DOI 10.1017/S0007114513003875
   Scavuzzi B., 2014, Ann Nutr Disord Ther, V1, P1009
   Sekhon B. S., 2010, Journal of Pharmaceutical Education and Research, V1, P13
   Sergeev IN, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010222
   Shakeri H, 2014, LIPIDS, V49, P695, DOI 10.1007/s11745-014-3901-z
   Simonnet A, 2020, OBESITY, V28, P1195, DOI 10.1002/oby.22831
   Singh N, 2014, IMMUNITY, V40, P128, DOI 10.1016/j.immuni.2013.12.007
   Singh RK, 2017, J TRANSL MED, V15, DOI 10.1186/s12967-017-1175-y
   Soleimani A, 2019, PROBIOTICS ANTIMICRO, V11, P1248, DOI 10.1007/s12602-018-9499-3
   Stanislawski MA, 2018, MBIO, V9, DOI [10.1128/mBio.01751-18, 10.1128/mbio.01751-18]
   Stenman LK, 2016, EBIOMEDICINE, V13, P190, DOI 10.1016/j.ebiom.2016.10.036
   Swanson KS, 2020, NAT REV GASTRO HEPAT, V17, P687, DOI 10.1038/s41575-020-0344-2
   Tajabadi-Ebrahimi M, 2017, EXP CLIN ENDOCR DIAB, V125, P21, DOI 10.1055/s-0042-105441
   Tajadadi-Ebrahimi M, 2014, ANN NUTR METAB, V65, P34, DOI 10.1159/000365153
   Turnbaugh PJ, 2007, NATURE, V449, P804, DOI 10.1038/nature06244
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Vallianou N, 2019, CURR OBES REP, V8, P317, DOI 10.1007/s13679-019-00352-2
   Voland L, 2022, OBES REV, V23, DOI 10.1111/obr.13377
   Wang X, 2021, FRONT PUBLIC HEALTH, V9, DOI 10.3389/fpubh.2021.645035
   Xavier-Santos D, 2020, J FUNCT FOODS, V64, DOI 10.1016/j.jff.2019.103666
   Yang JP, 2021, GUT MICROBES, V13, DOI 10.1080/19490976.2021.1987783
   Zhao Y, 2018, MUCOSAL IMMUNOL, V11, P752, DOI 10.1038/mi.2017.118
NR 94
TC 17
Z9 17
U1 1
U2 21
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD APR
PY 2022
VL 12
IS 4
AR 313
DI 10.3390/metabo12040313
PG 16
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 0S1LQ
UT WOS:000786043500001
PM 35448499
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Calle, MC
   Fernandez, ML
AF Calle, M. C.
   Fernandez, M. L.
TI Inflammation and type 2 diabetes
SO DIABETES & METABOLISM
LA English
DT Review
DE TNF-alpha; C-reactive protein; Adiponectin; Weight loss; Diet;
   Cardiovascular diseases; Type 2 diabetes; The metabolic syndrome
ID C-REACTIVE PROTEIN; TUMOR-NECROSIS-FACTOR; ADIPONECTIN GENE-EXPRESSION;
   ENDOPLASMIC-RETICULUM STRESS; ADIPOSE-SPECIFIC PROTEIN;
   INSULIN-RESISTANCE; WEIGHT-LOSS; FACTOR-ALPHA; DIETARY PATTERNS;
   ENDOTHELIAL DYSFUNCTION
AB Low-grade inflammation is a common feature in subjects with type 2 diabetes (T2D). Heart disease, the metabolic syndrome and T2D all have in common the increased concentration of circulatory cytokines as a result of inflammation. Inflammatory cytokines are produced by different cell types and secreted into the circulation, where they regulate different tissues through their local, central and peripheral actions. This review focuses on C-reactive protein (CRP), a well-established marker of the development of inflammation, on tumour necrosis factor (TNF)-alpha, an inflammatory marker strongly associated with diabetes, and on adiponectin, a cytokine produced by adipose tissue and associated with insulin sensitivity. While it is clear from the literature that these cytokines play a major role in the development of T2D or, in the case of adiponectin, its prevention, the best strategy for favourably altering the inflammatory response is still a matter of debate. (C) 2012 Elsevier Masson SAS. All rights reserved.
C1 [Calle, M. C.; Fernandez, M. L.] Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
C3 University of Connecticut
RP Fernandez, ML (corresponding author), Univ Connecticut, Dept Nutr Sci, 3624 Horsebarn Rd,Ext U-4017, Storrs, CT 06269 USA.
EM maria-luz.fernandez@uconn.edu
CR Alexandraki K, 2006, ANN NY ACAD SCI, V1084, P89, DOI 10.1196/annals.1372.039
   Amar J, 2011, DIABETOLOGIA, V54, P3055, DOI 10.1007/s00125-011-2329-8
   Amar J, 2011, EMBO MOL MED, V3, P559, DOI 10.1002/emmm.201100159
   [Anonymous], FEBS LETT
   Arita Y, 1999, BIOCHEM BIOPH RES CO, V257, P79, DOI 10.1006/bbrc.1999.0255
   Bastard JP, 2006, EUR CYTOKINE NETW, V17, P4
   Bastard JP, 2000, DIABETES OBES METAB, V2, P323, DOI 10.1046/j.1463-1326.2000.00090.x
   Bruun JM, 2003, AM J PHYSIOL-ENDOC M, V285, pE527, DOI 10.1152/ajpendo.00110.2003
   Burcelin R, 2011, ACTA DIABETOL, V48, P257, DOI 10.1007/s00592-011-0333-6
   Celec P, 2004, BIOMED PHARMACOTHER, V58, P365, DOI 10.1016/j.biopha.2003.12.015
   Cersosimo E, 2006, DIABETES-METAB RES, V22, P423, DOI 10.1002/dmrr.634
   Chen K, 2006, NAT MED, V12, P425, DOI 10.1038/nm1372
   Chung HY, 2009, AGEING RES REV, V8, P18, DOI 10.1016/j.arr.2008.07.002
   Cnop M, 2003, DIABETOLOGIA, V46, P459, DOI 10.1007/s00125-003-1074-z
   COPPACK SW, 1992, METABOLISM, V41, P264, DOI 10.1016/0026-0495(92)90269-G
   Coughlin CC, 2007, OBESITY, V15, P640, DOI 10.1038/oby.2007.556
   de Ferranti S, 2002, CLIN CHIM ACTA, V317, P1, DOI 10.1016/S0009-8981(01)00797-5
   Devaraj S, 2009, CLIN CHEM, V55, P229, DOI 10.1373/clinchem.2008.108886
   Egger G, 2009, OBES REV, V10, P237, DOI 10.1111/j.1467-789X.2008.00542.x
   Ekmekci H, 2006, CLIN APPL THROMB-HEM, V12, P163, DOI 10.1177/107602960601200203
   Esmaillzadeh A, 2007, J NUTR, V137, P992, DOI 10.1093/jn/137.4.992
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   Fasshauer M, 2003, DIABETOLOGIA, V46, P1594, DOI 10.1007/s00125-003-1228-z
   Fasshauer M, 2003, BIOCHEM BIOPH RES CO, V301, P1045, DOI 10.1016/S0006-291X(03)00090-1
   Gerszten RE, 1999, NATURE, V398, P718, DOI 10.1038/19546
   Giacco F, 2010, CIRC RES, V107, P1058, DOI 10.1161/CIRCRESAHA.110.223545
   Giugliano D, 2006, J AM COLL CARDIOL, V48, P677, DOI 10.1016/j.jacc.2006.03.052
   Heidemann C, 2005, DIABETOLOGIA, V48, P1126, DOI 10.1007/s00125-005-1743-1
   Herder C, 2009, DIABETOLOGIA, V52, P433, DOI 10.1007/s00125-008-1243-1
   Hotamisligil GS, 2008, INT J OBESITY, V32, pS52, DOI 10.1038/ijo.2008.238
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   Hotamisligil GS, 2008, NAT REV IMMUNOL, V8, P923, DOI 10.1038/nri2449
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Hotta K, 2000, ARTERIOSCL THROM VAS, V20, P1595, DOI 10.1161/01.ATV.20.6.1595
   Iwaki M, 2003, DIABETES, V52, P1655, DOI 10.2337/diabetes.52.7.1655
   Jovinge S, 1998, METABOLISM, V47, P113, DOI 10.1016/S0026-0495(98)90203-7
   Julius U, 2003, EXP CLIN ENDOCR DIAB, V111, P246, DOI 10.1055/s-2003-41284
   Kadowaki T, 2006, J CLIN INVEST, V116, P1784, DOI 10.1172/JCI29126
   Kant AK, 2010, APPL PHYSIOL NUTR ME, V35, P199, DOI 10.1139/H10-005
   KERN PA, 1995, J CLIN INVEST, V95, P2111, DOI 10.1172/JCI117899
   Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213
   Knights D, 2011, FEMS MICROBIOL REV, V35, P343, DOI 10.1111/j.1574-6976.2010.00251.x
   Larsen N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009085
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Libby P, 2009, J AM COLL CARDIOL, V54, P2129, DOI 10.1016/j.jacc.2009.09.009
   Lopez-Garcia E, 2004, AM J CLIN NUTR, V80, P1029, DOI 10.1093/ajcn/80.4.1029
   Madsen EL, 2008, EUR J ENDOCRINOL, V158, P179, DOI 10.1530/EJE-07-0721
   Masters RC, 2010, J NUTR, V140, P587, DOI 10.3945/jn.109.116640
   Murphy K., 2008, Janeway's Immunobiology
   Murray DR, 2003, CIRCULATION, V107, P1460, DOI 10.1161/01.CIR.0000060808.79274.0C
   Nettleton JA, 2006, AM J CLIN NUTR, V83, P1369, DOI 10.1093/ajcn/83.6.1369
   Ng TWK, 2007, DIABETES CARE, V30, P2945, DOI 10.2337/dc07-0768
   Ouchi N, 2000, CIRCULATION, V102, P1296, DOI 10.1161/01.CIR.102.11.1296
   Ouchi N, 2003, CIRCULATION, V107, P671, DOI 10.1161/01.CIR.0000055188.83694.B3
   Panagiotakos DB, 2008, VASC MED, V13, P113, DOI 10.1177/1358863x07087731
   Pannacciulli N, 2001, INT J OBESITY, V25, P1416, DOI 10.1038/sj.ijo.0801719
   Pasceri V, 2000, CIRCULATION, V102, P2165
   Pasceri V, 2001, CIRCULATION, V103, P2531
   Peppa M, 2009, WOUND REPAIR REGEN, V17, P461, DOI 10.1111/j.1524-475X.2009.00518.x
   Petersen AMW, 2005, J APPL PHYSIOL, V98, P1154, DOI 10.1152/japplphysiol.00164.2004
   Puglisi MJ, 2008, LIPIDS HEALTH DIS, V7, DOI 10.1186/1476-511X-7-14
   Puglisi MJ, 2008, J NUTR, V138, P2293, DOI 10.3945/jn.108.097188
   Qin BL, 2008, AM J PHYSIOL-GASTR L, V294, pG1120, DOI 10.1152/ajpgi.00407.2007
   Rader DJ, 2008, NATURE, V451, P904, DOI 10.1038/nature06796
   Ridker PM, 2008, NEW ENGL J MED, V359, P2195, DOI 10.1056/NEJMoa0807646
   Ridker PM, 2007, J AM COLL CARDIOL, V49, P2129, DOI 10.1016/j.jacc.2007.02.052
   Ronn SG, 2007, DIABETES, V56, P541, DOI 10.2337/db06-1068
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Rupnick MA, 2002, P NATL ACAD SCI USA, V99, P10730, DOI 10.1073/pnas.162349799
   Santos Maria Gisele dos, 2008, Arq Bras Cardiol, V90, P276
   Semenza GL, 2003, NAT REV CANCER, V3, P721, DOI 10.1038/nrc1187
   Sharman MJ, 2004, CLIN SCI, V107, P365, DOI 10.1042/CS20040111
   Shi H, 2006, J CLIN INVEST, V116, P3015, DOI 10.1172/JCI28898
   Simpson KA, 2008, OBESITY, V16, P241, DOI 10.1038/oby.2007.53
   Stephens JM, 1997, J BIOL CHEM, V272, P971, DOI 10.1074/jbc.272.2.971
   Trayhurn P, 2004, BRIT J NUTR, V92, P347, DOI 10.1079/BJN20041213
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Ungvari Z, 2010, J MOL MED, V88, P1021, DOI 10.1007/s00109-010-0667-5
   Viollet B, 2006, J PHYSIOL-LONDON, V574, P41, DOI 10.1113/jphysiol.2006.108506
   Vlassara H, 2002, P NATL ACAD SCI USA, V99, P15596, DOI 10.1073/pnas.242407999
   Wang B, 2008, J ENDOCRINOL, V198, P127, DOI 10.1677/JOE-08-0156
   Wang BH, 2006, PFLUG ARCH EUR J PHY, V452, P418, DOI 10.1007/s00424-006-0055-8
   Wannamethee SG, 2009, DIABETES CARE, V32, P1823, DOI 10.2337/dc09-0477
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Wood IS, 2009, P NUTR SOC, V68, P370, DOI 10.1017/S0029665109990206
   Yamagishi Sho-ichi, 2010, Front Biosci (Elite Ed), V2, P1184
   Yamauchi T, 2002, NAT MED, V8, P1288, DOI 10.1038/nm788
   Yamauchi T, 2001, NAT MED, V7, P941, DOI 10.1038/90984
   Yuan GY, 2007, J ENDOCRINOL, V194, P275, DOI 10.1677/JOE-07-0133
   Zacho J, 2008, NEW ENGL J MED, V359, P1897, DOI 10.1056/NEJMoa0707402
   Zern TL, 2005, J NUTR, V135, P1911, DOI 10.1093/jn/135.8.1911
   Zoetendal EG, 1998, APPL ENVIRON MICROB, V64, P3854
NR 93
TC 375
Z9 419
U1 1
U2 46
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 1262-3636
EI 1878-1780
J9 DIABETES METAB
JI Diabetes Metab.
PD JUN
PY 2012
VL 38
IS 3
BP 183
EP 191
DI 10.1016/j.diabet.2011.11.006
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 987QC
UT WOS:000307431200001
PM 22252015
DA 2025-06-11
ER

PT J
AU Charlebois, E
   Pantopoulos, K
AF Charlebois, Edouard
   Pantopoulos, Kostas
TI Nutritional Aspects of Iron in Health and Disease
SO NUTRIENTS
LA English
DT Review
DE iron deficiency; iron overload; anemia; heme; metabolic syndrome;
   cardiovascular disease; cancer; microbiome
ID SOLUBLE TRANSFERRIN RECEPTOR; SERUM FERRITIN CONCENTRATION;
   DOSE-RESPONSE METAANALYSIS; HEPATIC GLUCOSE-PRODUCTION;
   CORONARY-HEART-DISEASE; HEME IRON; INSULIN-RESISTANCE; DEFICIENCY
   ANEMIA; OXIDATIVE STRESS; GUT MICROBIOTA
AB Dietary iron assimilation is critical for health and essential to prevent iron-deficient states and related comorbidities, such as anemia. The bioavailability of iron is generally low, while its absorption and metabolism are tightly controlled to satisfy metabolic needs and prevent toxicity of excessive iron accumulation. Iron entry into the bloodstream is limited by hepcidin, the iron regulatory hormone. Hepcidin deficiency due to loss-of-function mutations in upstream gene regulators causes hereditary hemochromatosis, an endocrine disorder of iron overload characterized by chronic hyperabsorption of dietary iron, with deleterious clinical complications if untreated. The impact of high dietary iron intake and elevated body iron stores in the general population is not well understood. Herein, we summarize epidemiological data suggesting that a high intake of heme iron, which is abundant in meat products, poses a risk factor for metabolic syndrome pathologies, cardiovascular diseases, and some cancers. We discuss the clinical relevance and potential limitations of data from cohort studies, as well as the need to establish causality and elucidate molecular mechanisms.
C1 [Charlebois, Edouard; Pantopoulos, Kostas] Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ H3T 1E2, Canada.
   [Charlebois, Edouard; Pantopoulos, Kostas] McGill Univ, Dept Med, Montreal, PQ H4A 3J1, Canada.
C3 Jewish General Hospital - Montreal; Lady Davis Institute; McGill
   University
RP Pantopoulos, K (corresponding author), Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ H3T 1E2, Canada.; Pantopoulos, K (corresponding author), McGill Univ, Dept Med, Montreal, PQ H4A 3J1, Canada.
EM edouard.charlebois@mail.mcgill.ca; kostas.pantopoulos@mcgill.ca
OI Charlebois, Edouard/0000-0002-1872-3528
FU Canadian Institutes of Health Research (CIHR) [PJT-486651]; Natural
   Sciences and Engineering Research Council of Canada (NSERC); Fonds de
   recherche du Quebec-Sante (FRQS)
FX This research was funded by the Canadian Institutes of Health Research
   (CIHR; PJT-486651). EC was funded by fellowships from the Natural
   Sciences and Engineering Research Council of Canada (NSERC) and from the
   Fonds de recherche du Quebec-Sante (FRQS).
CR Aglago EK, 2023, BRIT J CANCER, V128, P1529, DOI 10.1038/s41416-023-02164-7
   Ahluwalia N, 2010, J NUTR, V140, P812, DOI 10.3945/jn.109.110353
   Al-Naseem A, 2021, CLIN MED, V21, P107, DOI 10.7861/clinmed.2020-0582
   Allameh A, 2022, COMMUN BIOL, V5, DOI 10.1038/s42003-022-03108-2
   Alnuwaysir RIS, 2022, J CLIN MED, V11, DOI 10.3390/jcm11010125
   Anand IS, 2018, CIRCULATION, V138, P80, DOI 10.1161/CIRCULATIONAHA.118.030099
   ARAUJO JA, 1995, ARTERIOSCL THROM VAS, V15, P1172, DOI 10.1161/01.ATV.15.8.1172
   Aschemeyer S, 2018, BLOOD, V131, P899, DOI 10.1182/blood-2017-05-786590
   Auerbach M, 2016, AM J HEMATOL, V91, P31, DOI 10.1002/ajh.24201
   Babitt JL, 2006, NAT GENET, V38, P531, DOI 10.1038/ng1777
   Bao W, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-119
   Basuli D, 2017, ONCOGENE, V36, P4089, DOI 10.1038/onc.2017.11
   Belkaid Y, 2017, IMMUNITY, V46, P562, DOI 10.1016/j.immuni.2017.04.008
   Berlin T, 2011, ISR MED ASSOC J, V13, P96
   Billesbolle CB, 2020, NATURE, V586, P807, DOI 10.1038/s41586-020-2668-z
   BOREL MJ, 1993, AM J PHYSIOL, V264, pE380, DOI 10.1152/ajpendo.1993.264.3.E380
   Bozzini C, 2005, DIABETES CARE, V28, P2061, DOI 10.2337/diacare.28.8.2061
   Camaschella C, 2015, NEW ENGL J MED, V372, P1832, DOI 10.1056/NEJMra1401038
   Cao H, 2017, EUR J CANCER CARE, V26, DOI 10.1111/ecc.12486
   CARPENTER CE, 1992, CRIT REV FOOD SCI, V31, P333, DOI 10.1080/10408399209527576
   Celis AI, 2023, CELL CHEM BIOL, V30, P110, DOI 10.1016/j.chembiol.2022.12.001
   Chang TPY, 2011, PEDIATR EMERG CARE, V27, P978, DOI 10.1097/PEC.0b013e3182302604
   Chang VC, 2019, BMC CANCER, V19, DOI 10.1186/s12885-019-5642-0
   Constante M, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01809
   Constante M, 2017, INFLAMM BOWEL DIS, V23, P753, DOI 10.1097/MIB.0000000000001089
   Crawford DHG, 2021, BBA-MOL BASIS DIS, V1867, DOI 10.1016/j.bbadis.2021.166142
   Cui R, 2019, FASEB J, V33, P1771, DOI 10.1096/fj.201800448R
   DAVIS RJ, 1986, J BIOL CHEM, V261, P8708
   De Sanctis V, 2016, EXPERT REV HEMATOL, V9, P401, DOI 10.1586/17474086.2016.1136209
   Deugnier Y, 2011, SEMIN LIVER DIS, V31, P260, DOI 10.1055/s-0031-1286057
   Vieira DAD, 2018, NUTRIENTS, V10, DOI 10.3390/nu10030314
   Fang X, 2015, NUTR METAB CARDIOVAS, V25, P24, DOI 10.1016/j.numecd.2014.09.002
   Fargion Silvia, 2014, Clin Liver Dis (Hoboken), V3, P108, DOI 10.1002/cld.350
   FARRELL PA, 1988, J NUTR, V118, P1104, DOI 10.1093/jn/118.9.1104
   Fathi ZH, 2022, TURK J PHARM SCI, V19, P603, DOI 10.4274/tjps.galenos.2021.29488
   Fernández-Real JM, 1998, DIABETES CARE, V21, P62, DOI 10.2337/diacare.21.1.62
   Fillebeen C, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21207773
   Finianos A, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19124070
   Ford ES, 1999, DIABETES CARE, V22, P1978, DOI 10.2337/diacare.22.12.1978
   Forslund K, 2015, NATURE, V528, P262, DOI 10.1038/nature15766
   Fu SM, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000002383
   Galaris D, 2019, BBA-MOL CELL RES, V1866, DOI 10.1016/j.bbamcr.2019.118535
   Gamage SMK, 2021, EXP MOL PATHOL, V120, DOI 10.1016/j.yexmp.2021.104642
   GBD 2016 Disease and Injury Incidence and Prevalence Collaborators, 2017, Lancet, V390, P1211, DOI 10.1016/S0140-6736(17)32154-2
   Girelli D, 2016, BLOOD, V127, P2809, DOI 10.1182/blood-2015-12-639112
   Gkouvatsos K, 2012, BBA-GEN SUBJECTS, V1820, P188, DOI 10.1016/j.bbagen.2011.10.013
   Gulec S, 2014, AM J PHYSIOL-GASTR L, V307, pG397, DOI 10.1152/ajpgi.00348.2013
   Gwamaka M, 2012, CLIN INFECT DIS, V54, P1137, DOI 10.1093/cid/cis010
   Han MH, 2020, ASIA PAC J CLIN NUTR, V29, P309, DOI 10.6133/apjcn.202007_29(2).0014
   Hansen JB, 2012, CELL METAB, V16, P449, DOI 10.1016/j.cmet.2012.09.001
   Huang JY, 2011, DIABETES, V60, P80, DOI 10.2337/db10-0593
   Huang Y, 2023, CRIT REV FOOD SCI, V63, P2910, DOI 10.1080/10408398.2021.1982861
   Hunnicutt J, 2014, J NUTR, V144, P359, DOI 10.3945/jn.113.185124
   Hurrell R, 2010, AM J CLIN NUTR, V91, p1461S, DOI 10.3945/ajcn.2010.28674F
   Husar-Memmer E, 2014, CURR RHEUMATOL REP, V16, DOI 10.1007/s11926-013-0393-4
   Ijssennagger N, 2015, P NATL ACAD SCI USA, V112, P10038, DOI 10.1073/pnas.1507645112
   Ijssennagger N, 2013, CARCINOGENESIS, V34, P1628, DOI 10.1093/carcin/bgt084
   IJssennagger N, 2012, GUT, V61, P1041, DOI 10.1136/gutjnl-2011-300239
   Infusino I, 2012, AM J CLIN PATHOL, V138, P642, DOI 10.1309/AJCP16NTXZLZFAIB
   Jaeggi T, 2015, GUT, V64, P731, DOI 10.1136/gutjnl-2014-307720
   Jahng JWS, 2019, EMBO REP, V20, DOI 10.15252/embr.201947911
   Jeney V, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00077
   Jeong SM, 2016, BIOCHEM BIOPH RES CO, V471, P373, DOI 10.1016/j.bbrc.2016.02.023
   Kataria Y, 2018, NUTRIENTS, V10, DOI 10.3390/nu10050621
   Katsarou A, 2020, MOL ASPECTS MED, V75, DOI 10.1016/j.mam.2020.100866
   Khambalia AZ, 2011, NUTR REV, V69, P693, DOI 10.1111/j.1753-4887.2011.00437.x
   Klisic A, 2023, ARCH MED SCI, V19, P987, DOI 10.5114/aoms/132757
   Kowdley KV, 2004, GASTROENTEROLOGY, V127, pS79, DOI 10.1016/j.gastro.2004.09.019
   Kremastinos DT, 2011, CIRCULATION, V124, P2253, DOI 10.1161/CIRCULATIONAHA.111.050773
   Kroot JJC, 2012, AM J HEMATOL, V87, P977, DOI 10.1002/ajh.23289
   Lakhal-Littleton S, 2016, ELIFE, V5, DOI 10.7554/eLife.19804
   Lakhal-Littleton S, 2015, P NATL ACAD SCI USA, V112, P3164, DOI 10.1073/pnas.1422373112
   Lee DH, 2006, DIABETES CARE, V29, P1090, DOI 10.2337/DC05-2471
   Lee T, 2017, GUT, V66, P863, DOI 10.1136/gutjnl-2015-309940
   Leung C, 2016, NAT REV GASTRO HEPAT, V13, P412, DOI 10.1038/nrgastro.2016.85
   LIPSCHITZ DA, 1974, NEW ENGL J MED, V290, P1213, DOI 10.1056/NEJM197405302902201
   Liu JF, 2020, J DIABETES INVEST, V11, P946, DOI 10.1111/jdi.13216
   Lynch S, 2018, J NUTR, V148, p1001S, DOI 10.1093/jn/nxx036
   Ma JF, 2018, NUTR RES, V59, P16, DOI 10.1016/j.nutres.2018.07.007
   Mahalhal A, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22073646
   Mahalhal A, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0202460
   MARCUS DM, 1975, J NATL CANCER I, V55, P791, DOI 10.1093/jnci/55.4.791
   Mayneris-Perxachs J, 2021, MICROBIOME, V9, DOI 10.1186/s40168-021-01052-7
   McKinnon EJ, 2014, CLIN GASTROENTEROL H, V12, P101, DOI 10.1016/j.cgh.2013.07.019
   Mendler MH, 1999, GASTROENTEROLOGY, V117, P1155, DOI 10.1016/S0016-5085(99)70401-4
   MERK K, 1990, INT J EPIDEMIOL, V19, P505, DOI 10.1093/ije/19.3.505
   Mir MB, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24065163
   Murali AR, 2018, HEPATOL RES, V48, pE30, DOI 10.1111/hepr.12921
   Nemeth E, 2004, SCIENCE, V306, P2090, DOI 10.1126/science.1104742
   Nemeth E, 2004, J CLIN INVEST, V113, P1271, DOI 10.1172/JCI200420945
   Nemeth E, 2023, ANNU REV MED, V74, P261, DOI 10.1146/annurev-med-043021-032816
   Nielsen OH, 2018, NUTRIENTS, V10, DOI 10.3390/nu10010082
   Osborne NJ, 2010, HEPATOLOGY, V51, P1311, DOI 10.1002/hep.23448
   OSHAUG A, 1995, EUR J CLIN NUTR, V49, P430
   Otto MCD, 2012, J NUTR, V142, P526, DOI 10.3945/jn.111.149781
   Özdemir A, 2007, ANN SAUDI MED, V27, P356, DOI 10.4103/0256-4947.51476
   Pantopoulos K, 2018, FRONT NUTR, V5, DOI 10.3389/fnut.2018.00103
   Pasricha SR, 2021, LANCET, V397, P233, DOI 10.1016/S0140-6736(20)32594-0
   Pelusi C, 2016, J ENDOCRINOL INVEST, V39, P837, DOI 10.1007/s40618-016-0451-7
   Vaquero MP, 2020, PEERJ, V8, DOI 10.7717/peerj.9528
   Pinnix ZK, 2010, SCI TRANSL MED, V2, DOI [10.1126/scitranslmed.3001127, 10.1126/scisignal.3001127]
   Pivina L, 2019, J MOL NEUROSCI, V68, P1, DOI 10.1007/s12031-019-01276-1
   Pottie K, 2011, CAN MED ASSOC J, V183, pE824, DOI 10.1503/cmaj.090313
   Qiao L, 2013, CANCER CAUSE CONTROL, V24, P1175, DOI 10.1007/s10552-013-0197-x
   Radulescu S, 2012, CELL REP, V2, P270, DOI 10.1016/j.celrep.2012.07.003
   Ramírez-Carmona W, 2022, NUTR CANCER, V74, P1917, DOI 10.1080/01635581.2021.1982996
   Sachinidis A, 2020, CURR PHARM DESIGN, V26, P1019, DOI 10.2174/1381612826666200130090703
   Salah HM, 2023, ESC HEART FAIL, V10, P1473, DOI 10.1002/ehf2.14310
   Sawada H, 2015, ARTERIOSCL THROM VAS, V35, P1507, DOI 10.1161/ATVBAHA.115.305586
   Schonberg DL, 2015, CANCER CELL, V28, P441, DOI 10.1016/j.ccell.2015.09.002
   Shahinfar H, 2022, EUR J NUTR, V61, P2279, DOI 10.1007/s00394-022-02813-2
   Shin DH, 2015, ANN CLIN LAB SCI, V45, P396
   Song M, 2019, CLIN GASTROENTEROL H, V17, P275, DOI 10.1016/j.cgh.2018.07.012
   Speeckaert MM, 2010, CRIT REV CL LAB SCI, V47, P213, DOI 10.3109/10408363.2010.550461
   SULLIVAN JL, 1981, LANCET, V1, P1293
   Sung HK, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-41111-6
   Tesfay L, 2015, CANCER RES, V75, P2254, DOI 10.1158/0008-5472.CAN-14-2465
   Torti SV, 2018, ANNU REV NUTR, V38, P97, DOI 10.1146/annurev-nutr-082117-051732
   Trumbo P, 2001, J AM DIET ASSOC, V101, P294, DOI 10.1016/S0002-8223(01)00078-5
   Uauy R, 2002, J NUTR, V132, p849S, DOI 10.1093/jn/132.4.849S
   Utzschneider KM, 2010, NAT REV ENDOCRINOL, V6, P26, DOI 10.1038/nrendo.2009.241
   van der Vorm LN, 2016, CLIN CHEM, V62, P993, DOI 10.1373/clinchem.2016.256768
   Vinchi F, 2020, EUR HEART J, V41, P2681, DOI 10.1093/eurheartj/ehz112
   WALTERS GO, 1973, J CLIN PATHOL, V26, P770, DOI 10.1136/jcp.26.10.770
   Ward HA, 2019, EUR J CLIN NUTR, V73, P1122, DOI 10.1038/s41430-018-0271-2
   Weinberg ED, 2010, METALLOMICS, V2, P732, DOI 10.1039/c0mt00023j
   Weiss G, 2019, BLOOD, V133, P40, DOI 10.1182/blood-2018-06-856500
   Wen CP, 2014, CANCER RES, V74, P6589, DOI 10.1158/0008-5472.CAN-14-0360
   World Health Organization, 2008, WORLDWIDE PREVALENCE
   Xu WJ, 2015, CELL REP, V13, P533, DOI 10.1016/j.celrep.2015.09.023
   Yang W, 2014, EUR J NUTR, V53, P395, DOI 10.1007/s00394-013-0535-5
   Zacharski LR, 2008, JNCI-J NATL CANCER I, V100, P996, DOI 10.1093/jnci/djn209
   Zakrzewski M, 2022, BIOMETALS, V35, P27, DOI 10.1007/s10534-021-00348-3
   Zhabyeyev P, 2017, EUR HEART J, V38, P373, DOI 10.1093/eurheartj/ehw386
NR 134
TC 43
Z9 44
U1 5
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY 24
PY 2023
VL 15
IS 11
AR 2441
DI 10.3390/nu15112441
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA I9BX5
UT WOS:001005672700001
PM 37299408
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Leisegang, K
   Sengupta, P
   Agarwal, A
   Henkel, R
AF Leisegang, Kristian
   Sengupta, Pallav
   Agarwal, Ashok
   Henkel, Ralf
TI Obesity and male infertility: Mechanisms and management
SO ANDROLOGIA
LA English
DT Review
DE male infertility; metabolic syndrome; obesity; semen quality
ID BODY-MASS INDEX; MALE REPRODUCTIVE FUNCTION; GERM-CELL APOPTOSIS;
   METABOLIC SYNDROME; MALE-FERTILITY; SEMEN QUALITY; TESTICULAR
   MORPHOLOGY; BARIATRIC SURGERY; LEPTIN; TESTOSTERONE
AB Obesity is considered a global health problem affecting more than a third of the population. Complications of obesity include cardiovascular diseases, type 2 diabetes mellitus, malignancy (including prostatic cancer), neurodegeneration and accelerated ageing. In males, these further include erectile dysfunction, poor semen quality and subclinical prostatitis. Although poorly understood, important mediators of obesity that may influence the male reproductive system include hyperinsulinemia, hyperleptinemia, chronic inflammation and oxidative stress. Obesity is known to disrupt male fertility and the reproduction potential, particularly through alteration in the hypothalamic-pituitary-gonadal axis, disruption of testicular steroidogenesis and metabolic dysregulation, including insulin, cytokines and adipokines. Importantly, obesity and its underlying mediators result in a negative impact on semen parameters, including sperm concentration, motility, viability and normal morphology. Moreover, obesity inhibits chromatin condensation, DNA fragmentation, increases apoptosis and epigenetic changes that can be transferred to the offspring. This review discusses the impact of obesity on the male reproductive system and fertility, including associated mechanisms. Furthermore, weight management strategies, lifestyle changes, prescription medication, and complementary and alternative medicine in the management of obesity-induced subfertility is discussed.
C1 [Leisegang, Kristian] Univ Western Cape, Sch Nat Med, Cape Town, South Africa.
   [Sengupta, Pallav] MAHSA Univ, Dept Physiol, Fac Med Biosci & Nursing, Jenjarom, Selangor, Malaysia.
   [Agarwal, Ashok; Henkel, Ralf] Cleveland Clin, Amer Ctr Reprod Med, Cleveland, OH 44106 USA.
   [Henkel, Ralf] Univ Western Cape, Dept Med Biosci, Cape Town, South Africa.
C3 University of the Western Cape; Mahsa University; Cleveland Clinic
   Foundation; University of the Western Cape
RP Leisegang, K (corresponding author), Univ Western Cape, Sch Nat Med, Cape Town, South Africa.
EM kleisegang@uwc.ac.za
RI Leisegang, Kristian/AAS-3925-2021; Sengupta, Pallav/E-3392-2016
OI Sengupta, Pallav/0000-0002-1928-5048; Henkel, Ralf/0000-0003-1128-2982;
   Leisegang, Kristian/0000-0002-3003-8048
CR Adler MI, 2013, EXP GERONTOL, V48, P539, DOI 10.1016/j.exger.2013.03.007
   Agarwal A., 2020, Male infertility: contemporary clinical approaches, andrology, ART and antioxidants, P497, DOI DOI 10.1007/978-3-030-32300-4_39
   Agarwal A, 2016, TRANSL ANDROL UROL, V5, P935, DOI [10.21037/tau.2016.10.03, 10.21037/tau.2017.08.14]
   Agarwal A, 2016, CURR OPIN OBSTET GYN, V28, P164, DOI 10.1097/GCO.0000000000000271
   Ahima RS, 2008, J CLIN INVEST, V118, P2380, DOI 10.1172/JCI36284
   Alhashem F, 2014, EXCLI J, V13, P551
   Almabhouh F, 2020, REPROD BIOL, V20, P106, DOI 10.1016/j.repbio.2020.01.003
   Almabhouh FA, 2020, ANDROLOGIA, V52, DOI 10.1111/and.13433
   Alvarez-Castro P, 2013, MINI-REV MED CHEM, V13, P541, DOI 10.2174/1389557511313040007
   [Anonymous], 2010, WHO Laboratory Manual for the Examination and Processing of Human Semen
   Barja G, 2014, PROG MOL BIOL TRANSL, V127, P1, DOI 10.1016/B978-0-12-394625-6.00001-5
   Benchaib M, 2007, FERTIL STERIL, V87, P93, DOI 10.1016/j.fertnstert.2006.05.057
   Bendre SV., 2015, REPROD SYST SEX DISO, V4, P155, DOI [10.4172/2161-038X.1000155, DOI 10.4172/2161-038X.1000155]
   Bessesen D., 2004, J CLIN ENDOCR METAB, V89, DOI [10.1210/jcem.89.4.9996, DOI 10.1210/JCEM.89.4.9996]
   Bhat GK, 2006, J ANDROL, V27, P302, DOI 10.2164/jandrol.05133
   Bieniek JM, 2016, FERTIL STERIL, V106, P1070, DOI 10.1016/j.fertnstert.2016.06.041
   Biswas A, 2017, INT J PHARM SCI RES, V8, P5065, DOI 10.13040/IJPSR.0975-8232.8(12).5065-71
   Blache D, 2003, REPRODUCTION, P387
   Caprio M, 1999, ENDOCRINOLOGY, V140, P4939, DOI 10.1210/en.140.11.4939
   CARLSEN E, 1992, BRIT MED J, V305, P609, DOI 10.1136/bmj.305.6854.609
   Castro AM., 2017, Revista Medica del Hospital General de Mexico, V80, P101, DOI [10.1016/j.hgmx.2016.06, DOI 10.1016/J.HGMX.2016.06]
   Chavarro JE, 2010, FERTIL STERIL, V93, P2222, DOI 10.1016/j.fertnstert.2009.01.100
   CHIMENTO A, 2014, FRONT ENDOCRINOL, V5
   Clarke H, 2015, ENDOCRINOL METAB, V30, P124, DOI 10.3803/EnM.2015.30.2.124
   Danielewicz A, 2018, NUTRIENTS, V10, DOI 10.3390/nu10091162
   Davidson LM, 2015, HUM FERTIL, V18, P184, DOI 10.3109/14647273.2015.1070438
   Deepinder Fnu, 2008, Endocr Pract, V14, P484
   DEROOIJ DG, 1986, BIOL REPROD, V35, P587, DOI 10.1095/biolreprod35.3.587
   di Frega AS, 2005, HUM REPROD, V20, P997, DOI 10.1093/humrep/deh707
   Du Plessis SS, 2010, NAT REV UROL, V7, P153, DOI 10.1038/nrurol.2010.6
   Duffy CM, 2016, MOL CELL NEUROSCI, V75, P93, DOI 10.1016/j.mcn.2016.07.003
   Dutta S., 2019, Asian Pacific Journal of Reproduction, V8, P195, DOI DOI 10.4103/2305-0500.268133
   Dutta S., 2019, ASIAN PAC J REPROD, V8, P244, DOI [10.4103/2305-0500.268153, DOI 10.4103/2305-0500.268153]
   Dutta S., 2019, ASIAN PAC J REPROD, V8, P227, DOI DOI 10.4103/2305-0500.268144
   Dutta S., 2019, Asian Pacific Journal of Reproduction, V8, P189, DOI [DOI 10.4103/2305-0500.268132, 10.4103/2305-0500.268132]
   Ferreira C, 2015, CURR PHARM DESIGN, V21, P3621, DOI 10.2174/1381612821666150710150041
   Flehmig G, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0099785
   Garolla A, 2013, HUM REPROD, V28, P877, DOI 10.1093/humrep/det020
   Gaskins AJ, 2012, HUM REPROD, V27, P2899, DOI 10.1093/humrep/des298
   Håkonsen LB, 2011, REPROD HEALTH, V8, DOI 10.1186/1742-4755-8-24
   Hammiche F, 2011, J ANDROL, V32, P70, DOI 10.2164/jandrol.109.009647
   Hammoud AO, 2008, FERTIL STERIL, V90, P897, DOI 10.1016/j.fertnstert.2008.08.026
   Hammoud AO, 2006, J ANDROL, V27, P619, DOI 10.2164/jandrol.106.000125
   Haslam DW, 2005, LANCET, V366, P1197, DOI 10.1016/S0140-6736(05)67483-1
   Hikim APS, 1999, REV REPROD, V4, P38
   Huang PL, 2009, DIS MODEL MECH, V2, P231, DOI 10.1242/dmm.001180
   Irez T., 2019, ASIAN PAC J REPROD, V8, P239, DOI DOI 10.4103/2305-0500.268146
   Ishikawa T, 2007, J ANDROL, V28, P320, DOI 10.2164/jandrol.106.000810
   JAROW J, 2011, AM UR ASS
   Jensen TK, 2004, FERTIL STERIL, V82, P863, DOI 10.1016/j.fertnstert.2004.03.056
   JENSEN TK, 2020, JAMA NETW OPEN, V3
   Jia YF, 2018, BMC UROL, V18, DOI 10.1186/s12894-018-0360-5
   Kahn BE, 2017, CURR OPIN UROL, V27, P441, DOI 10.1097/MOU.0000000000000417
   Karayiannis D, 2017, HUM REPROD, V32, P215, DOI 10.1093/humrep/dew288
   Katib A, 2015, CENT EUR J UROL, V68, P79, DOI 10.5173/ceju.2015.01.435
   Kelly T, 2008, INT J OBESITY, V32, P1431, DOI 10.1038/ijo.2008.102
   Leisegang K, 2014, ANDROLOGIA, V46, P167, DOI 10.1111/and.12060
   Leisegang K., 2019, OXIDANTS ANTIOXIDANT, P117
   Leisegang K, 2019, AM J REPROD IMMUNOL, V82, DOI 10.1111/aji.13178
   Leisegang K, 2018, REPROD BIOL ENDOCRIN, V16, DOI 10.1186/s12958-018-0341-2
   Leisegang K, 2017, CURR PHARM DESIGN, V23, P4438, DOI 10.2174/1381612822666161019150241
   Leisegang K, 2016, AM J REPROD IMMUNOL, V76, P155, DOI 10.1111/aji.12529
   Li Cheng-yong, 2015, Zhonghua Nan Ke Xue, V21, P402
   Linabery AM, 2013, PEDIATR OBES, V8, P159, DOI 10.1111/j.2047-6310.2012.00100.x
   Liu Y, 2017, REPRODUCTION, V154, pR123, DOI [10.1530/REP-17-0161, 10.1530/rep-17-0161]
   Malik IA, 2019, ASIAN J ANDROL, V21, P296, DOI 10.4103/aja.aja_98_18
   Maneesh M, 2006, INDIAN J CLIN BIOCHE, V21, P80, DOI 10.1007/BF02912918
   Maresch CC, 2018, HUM REPROD UPDATE, V24, P86, DOI 10.1093/humupd/dmx033
   Martins AD, 2019, WORLD J MENS HEALTH, V37, P113, DOI 10.5534/wjmh.180055
   McPherson NO, 2015, ASIAN J ANDROL, V17, P450, DOI 10.4103/1008-682X.148076
   Meldrum D.R., 2017, Fertil Steril, V107
   Mir J, 2018, ANDROLOGIA, V50, DOI 10.1111/and.12957
   Moatt JP, 2016, BMC EVOL BIOL, V16, DOI 10.1186/s12862-016-0768-z
   Mora-Esteves C, 2013, SEMIN REPROD MED, V31, P293, DOI 10.1055/s-0033-1345277
   Mounzih K, 1997, ENDOCRINOLOGY, V138, P1190, DOI 10.1210/en.138.3.1190
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Ojeda SR, 2006, ENDOCRINOLOGY, V147, P1166, DOI 10.1210/en.2005-1136
   Okorodudu DO, 2010, INT J OBESITY, V34, P791, DOI 10.1038/ijo.2010.5
   OLIVA MM, 2016, INT J ENDOCRINOLOGY, V2016
   Page ST, 2005, J ANDROL, V26, P85
   Payab M, 2020, PHYTOTHER RES, V34, P526, DOI 10.1002/ptr.6547
   Perez-Leighton CE, 2013, INT J OBESITY, V37, P167, DOI 10.1038/ijo.2012.30
   Ramos CF, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00198
   Reis LO, 2012, REPROD SCI, V19, P778, DOI 10.1177/1933719112440053
   Ring JD, 2016, ASIAN J ANDROL, V18, P357, DOI 10.4103/1008-682X.179252
   Roth MY, 2008, NAT CLIN PRACT ENDOC, V4, P415, DOI 10.1038/ncpendmet0844
   Roychoudhury S, 2017, REPROD BIOMED ONLINE, V34, P487, DOI 10.1016/j.rbmo.2017.02.006
   Salas-Huetos A, 2017, HUM REPROD UPDATE, V23, P371, DOI 10.1093/humupd/dmx006
   Salazar M., 2018, J Reprod Gynecol Obstet, V3, P1
   Sansone A., 2018, Reprod. Biol. Endocrinol. RBE, V16
   Sarwer DB, 2018, CURR OBES REP, V7, P301, DOI 10.1007/s13679-018-0319-6
   Schliep KC, 2015, FERTIL STERIL, V103, P388, DOI 10.1016/j.fertnstert.2014.10.048
   Schulster M, 2016, ASIAN J ANDROL, V18, P435, DOI 10.4103/1008-682X.173932
   Seftel A, 2006, INT J IMPOT RES, V18, P223, DOI 10.1038/sj.ijir.3901365
   SELVAM MP, 2020, GENETICS MALE INFERT
   Sengupta P, 2019, Asian Pacific J Reproduct, V8, P220, DOI [10.4103/2305-0500.268143, DOI 10.4103/2305-0500.268143]
   Sengupta P., 2018, ASIAN PAC J REPROD, V7, P87, DOI [10.4103/2305-0500.228018, DOI 10.4103/2305-0500.228018]
   Sengupta P, 2019, ASIAN PACIFIC J REPR, DOI [10.4103/2305-0500.268145, DOI 10.4103/2305-0500.268145]
   Sengupta P, 2018, REPROD BIOMED ONLINE, V36, P311, DOI 10.1016/j.rbmo.2017.11.007
   Sengupta P, 2017, AM J MENS HEALTH, V11, P1279, DOI 10.1177/1557988316643383
   Sermondade N, 2013, ASIAN J ANDROL, V15, P626, DOI 10.1038/aja.2013.10
   Sermondade N, 2012, REPROD BIOMED ONLINE, V24, P206, DOI 10.1016/j.rbmo.2011.10.014
   Setayesh T, 2018, MUTAT RES-REV MUTAT, V777, P64, DOI 10.1016/j.mrrev.2018.07.001
   Shamloul R, 2013, LANCET, V381, P153, DOI 10.1016/S0140-6736(12)60520-0
   Singh H, 2019, ENDOCR METAB IMMUNE, V19, P481, DOI 10.2174/1871530319666181130142642
   Sitzmann BD, 2014, AGE, V36, P183, DOI 10.1007/s11357-013-9563-6
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Soubry A, 2016, CLIN EPIGENETICS, V8, DOI 10.1186/s13148-016-0217-2
   Soubry A, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-29
   Stephens SM, 2013, SEMIN REPROD MED, V31, P251, DOI 10.1055/s-0033-1345272
   Tall AR, 2015, NAT REV IMMUNOL, V15, P104, DOI 10.1038/nri3793
   Teerds KJ, 2011, HUM REPROD UPDATE, V17, P667, DOI 10.1093/humupd/dmr017
   Thaler JP, 2010, ENDOCRINOLOGY, V151, P4109, DOI 10.1210/en.2010-0336
   Tsai EC, 2004, DIABETES CARE, V27, P861, DOI 10.2337/diacare.27.4.861
   Umul M, 2015, ANDROLOGIA, V47, P360, DOI 10.1111/and.12272
   Wan FY, 2017, 2017 IEEE INTERNATIONAL CONFERENCE ON PROGNOSTICS AND HEALTH MANAGEMENT (ICPHM), P160, DOI 10.1109/ICPHM.2017.7998322
   Wang C, 2011, DIABETES CARE, V34, P1669, DOI 10.2337/dc10-2339
   Wei Y, 2018, MED SCI MONIT BASIC, V24, P188, DOI 10.12659/MSMBR.910862
   WHO Consultation, 2000, WHO TECH REP SER, V894, P1
   Winter AG, 2014, TRANSL ANDROL UROL, V3, P50, DOI 10.3978/j.issn.2223-4683.2014.01.04
   Wofford Marion R, 2006, J Clin Hypertens (Greenwich), V8, P114, DOI 10.1111/j.1524-6175.2006.04751.x
   Wolfe A, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00184
   Yamagishi SI, 2001, J BIOL CHEM, V276, P25096, DOI 10.1074/jbc.M007383200
   Ye JF, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/9151067
   Zheng D, 2014, J ENDOCRINOL INVEST, V37, P285, DOI 10.1007/s40618-013-0035-8
NR 125
TC 176
Z9 184
U1 6
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-4569
EI 1439-0272
J9 ANDROLOGIA
JI Andrologia
PD FEB
PY 2021
VL 53
IS 1
SI SI
AR e13617
DI 10.1111/and.13617
EA MAY 2020
PG 14
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA PZ8AA
UT WOS:000531805400001
PM 32399992
DA 2025-06-11
ER

PT J
AU Lakkis, JI
   Weir, MR
AF Lakkis, Jay I.
   Weir, Mathew R.
TI Obesity and Kidney Disease
SO PROGRESS IN CARDIOVASCULAR DISEASES
LA English
DT Review
DE Obesity; Chronic kidney disease; Metabolic syndrome;
   Metabolically-healthy obesity; Obesity-related hypertension; Leptin;
   Adiponectin
ID OBSTRUCTIVE SLEEP-APNEA; BODY-MASS INDEX; ANGIOTENSIN-ALDOSTERONE
   SYSTEM; METABOLICALLY HEALTHY OBESITY; CLINICAL-PRACTICE GUIDELINE;
   DIETARY-SODIUM RESTRICTION; FATTY-ACID OXIDATION; GUT-BRAIN AXIS;
   ADIPOSE-TISSUE; RESISTANT HYPERTENSION
AB Obesity is a systemic disease of the white adipose tissue, which has evolved into a global epidemic. It is associated with a plethora of adipocyte hormonal (adipokine) imbalances, dysregulation of the energy-balance system, imbalances in metabolic homeostasis, a pro-inflammatory state and multiple target organ damages. Clinically, the obesity phenotype is not homogenous and is more likely to represent a spectrum with varying degrees of metabolic un-health; metabolically-unhealthy obesity is often a part of the metabolic syndrome. The links between obesity and chronic kidney disease are numerous, bidirectional, multi-layered and complex; this complexity may be explained by shared pathophysiological pathways (e.g. chronic inflammation, increased oxidative stress, and hyper-insulinemia), shared clusters of risk factors as well as associated diseases (e.g. insulin resistance, hypertension and dyslipidemia). We will review these links and their clinical manifestations, and offer a summary of available non-pharmacological as well as pharmacological therapeutic strategies. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Lakkis, Jay I.] Univ Hawaii, John A Burns Sch Med, 95 Maui Lani Pkwy, Wailuku, HI 96793 USA.
   [Weir, Mathew R.] Univ Maryland, Sch Med, Div Nephrol, 22 S Greene St,Room N3W143, Baltimore, MD 21201 USA.
C3 University System of Maryland; University of Maryland Baltimore
RP Weir, MR (corresponding author), Univ Maryland, Sch Med, Div Nephrol, 22 S Greene St,Room N3W143, Baltimore, MD 21201 USA.
EM mweir@medicine.umaryland.edu
CR Abbasi F, 2002, J AM COLL CARDIOL, V40, P937, DOI 10.1016/S0735-1097(02)02051-X
   Afshin A, 2017, NEW ENGL J MED, V377, P13, DOI 10.1056/NEJMoa1614362
   Akingbemi BT, 2013, PROG MOL BIOL TRANSL, V114, P317, DOI 10.1016/B978-0-12-386933-3.00009-1
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   [Anonymous], 2004, AM J KIDNEY DIS
   [Anonymous], J AM HEART ASS
   [Anonymous], T AM CLIN CLIMATOL A
   [Anonymous], 2018, METABOLISM
   [Anonymous], 219NCHS DATA BRI NOV
   [Anonymous], CLIN RESP J
   [Anonymous], 2013, Acad Forensic Pathol., DOI DOI 10.23907/2013.002
   [Anonymous], KIDNEY INT S2
   Arici M, 2009, AM J KIDNEY DIS, V53, P332, DOI 10.1053/j.ajkd.2008.11.021
   Arita Y, 1999, BIOCHEM BIOPH RES CO, V257, P79, DOI 10.1006/bbrc.1999.0255
   Arner P, 2015, NAT REV ENDOCRINOL, V11, P276, DOI 10.1038/nrendo.2015.25
   Asplin JR, 2009, ADV CHRONIC KIDNEY D, V16, P11, DOI 10.1053/j.ackd.2008.10.003
   Berenbaum F, 2013, CURR OPIN RHEUMATOL, V25, P114, DOI 10.1097/BOR.0b013e32835a9414
   Bergman RN, 2001, J INVEST MED, V49, P119, DOI 10.2310/6650.2001.34108
   Björnson E, 2017, CURR OPIN LIPIDOL, V28, P11, DOI 10.1097/MOL.0000000000000375
   Bobulescu IA, 2010, CURR OPIN NEPHROL HY, V19, P393, DOI 10.1097/MNH.0b013e32833aa4ac
   Boden-Albala B, 2000, Curr Atheroscler Rep, V2, P160, DOI 10.1007/s11883-000-0111-3
   Bogaert YE, 2009, NAT CLIN PRACT NEPHR, V5, P101, DOI 10.1038/ncpneph1022
   Cai ZJ, 1999, WHO TECH REP SER, V887, P1
   Campello E, 2015, THROMB RES, V135, P548, DOI 10.1016/j.thromres.2015.01.003
   Campello E, 2015, THROMB HAEMOSTASIS, V113, P85, DOI 10.1160/TH14-02-0156
   Canale MP, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/865965
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cao X, 2015, BMC NEPHROL, V16, DOI 10.1186/s12882-015-0083-8
   Cat AND, 2016, J MOL ENDOCRINOL, V57, pF7, DOI 10.1530/JME-16-0025
   Chagnac A, 2000, AM J PHYSIOL-RENAL, V278, pF817, DOI 10.1152/ajprenal.2000.278.5.F817
   Chang AR, 2016, KIDNEY INT, V90, P164, DOI 10.1016/j.kint.2016.02.039
   Chang Y, 2016, ANN INTERN MED, V164, P305, DOI 10.7326/M15-1323
   Chau BN, 2012, SCI TRANSL MED, V4, DOI 10.1126/scitranslmed.3003205
   Chen HM, 2006, AM J KIDNEY DIS, V48, P772, DOI 10.1053/j.ajkd.2006.07.025
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Chitongo P B, 2017, TH Open, V1, pe146, DOI 10.1055/s-0037-1608942
   Collins KH, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00112
   Cypess AM, 2009, NEW ENGL J MED, V360, P1509, DOI 10.1056/NEJMoa0810780
   D'Elia L, 2015, CLIN J AM SOC NEPHRO, V10, P1542, DOI 10.2215/CJN.09110914
   De Pergola G, 2018, ENDOCR METAB IMMUNE, V18, P251, DOI 10.2174/1871530318666180212101548
   Di Francesco V, 2004, OBES SURG, V14, P1095, DOI 10.1381/0960892041975622
   Diehl AM, 2017, NEW ENGL J MED, V377, P2063, DOI 10.1056/NEJMra1503519
   Dixon JB, 2001, ARCH INTERN MED, V161, P102, DOI 10.1001/archinte.161.1.102
   Drager LF, 2013, J AM COLL CARDIOL, V62, P569, DOI 10.1016/j.jacc.2013.05.045
   Eckel N, 2018, LANCET DIABETES ENDO, V6, P714, DOI 10.1016/S2213-8587(18)30137-2
   Ehrhart-Bornstein M, 2003, P NATL ACAD SCI USA, V100, P14211, DOI 10.1073/pnas.2336140100
   Ejerblad E, 2006, J AM SOC NEPHROL, V17, P1695, DOI 10.1681/ASN.2005060638
   Engeli S, 2003, INT J BIOCHEM CELL B, V35, P807, DOI 10.1016/S1357-2725(02)00311-4
   Ferris M, 2007, CLIN J AM SOC NEPHRO, V2, P1207, DOI 10.2215/CJN.00540107
   Festa A, 2001, INT J OBESITY, V25, P1407, DOI 10.1038/sj.ijo.0801792
   Francisco V, 2018, J ORTHOP RES, V36, P594, DOI 10.1002/jor.23788
   Franssen R, 2011, MED CLIN N AM, V95, P893, DOI 10.1016/j.mcna.2011.06.003
   Friedman AN, 2018, J AM SOC NEPHROL, V29, P1289, DOI 10.1681/ASN.2017060707
   GARRISON RJ, 1987, PREV MED, V16, P235, DOI 10.1016/0091-7435(87)90087-9
   Garvey WT, 2016, ENDOCR PRACT, V22, P1, DOI 10.4158/EP161365.GL
   Gaynor JJ, 2015, CLIN TRANSPLANT, V29, P301, DOI 10.1111/ctr.12510
   Girillo P, 2006, J AM SOC NEPHROL, V17, pS165, DOI 10.1681/ASN.2006080909
   Glanton CW, 2003, KIDNEY INT, V63, P647, DOI 10.1046/j.1523-1755.2003.00761.x
   Goodfriend TL, 2004, HYPERTENSION, V43, P518, DOI 10.1161/01.HYP.0000116223.97436.e5
   Goossens G H, 2003, Obes Rev, V4, P43
   Grabitske HA, 2008, J AM DIET ASSOC, V108, P1677, DOI 10.1016/j.jada.2008.07.010
   Grams ME, 2016, NEW ENGL J MED, V374, P411, DOI 10.1056/NEJMoa1510491
   Griffin KA, 2008, AM J PHYSIOL-RENAL, V294, pF695, DOI 10.1152/ajprenal.00324.2007
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Grundy SM, 1998, AM J CARDIOL, V81, p18B, DOI 10.1016/S0002-9149(98)00033-2
   GRUNSTEIN R, 1993, INT J OBESITY, V17, P533
   Hajer GR, 2008, EUR HEART J, V29, P2959, DOI 10.1093/eurheartj/ehn387
   Hales CM, 2018, JAMA-J AM MED ASSOC, V319, P1723, DOI 10.1001/jama.2018.3060
   Hashimoto Y, 2015, CLIN J AM SOC NEPHRO, V10, P578, DOI 10.2215/CJN.08980914
   Haynes WG, 1997, J CLIN INVEST, V100, P270, DOI 10.1172/JCI119532
   Heymsfield SB, 2017, NEW ENGL J MED, V376, P254, DOI 10.1056/NEJMra1514009
   Hikita M, 2007, INTERNAL MED, V46, P1353, DOI 10.2169/internalmedicine.46.0045
   Hill CJ, 2015, NEPHROL DIAL TRANSPL, V30, P1403, DOI 10.1093/ndt/gfv214
   Hotamisligil GS, 2003, INT J OBESITY, V27, pS53, DOI 10.1038/sj.ijo.0802502
   Hou HF, 2018, J GLOB HEALTH, V8, DOI 10.7189/jogh.08.010405
   Hsu CY, 2006, ANN INTERN MED, V144, P21, DOI 10.7326/0003-4819-144-1-200601030-00006
   Huby AC, 2015, CIRCULATION, V132, P2134, DOI 10.1161/CIRCULATIONAHA.115.018226
   Izquierdo-Lahuerta A, 2016, J NEPHROL, V29, P603, DOI 10.1007/s40620-016-0278-5
   Jalal DI, 2010, J AM SOC NEPHROL, V21, P1543, DOI 10.1681/ASN.2009111111
   James PA, 2014, JAMA-J AM MED ASSOC, V311, P1809, DOI [10.1001/jama.2013.284427, 10.1001/jama.2014.4346]
   Johnson RJ, 2010, J AM SOC NEPHROL, V21, P2036, DOI 10.1681/ASN.2010050506
   Johnson RJ, 2009, ENDOCR REV, V30, P96, DOI 10.1210/er.2008-0033
   Joles JA, 2000, J AM SOC NEPHROL, V11, P669, DOI 10.1681/ASN.V114669
   Kambham N, 2001, KIDNEY INT, V59, P1498, DOI 10.1046/j.1523-1755.2001.0590041498.x
   Kang YB, 2017, HORM-INT J ENDOCRINO, V16, P223, DOI 10.14310/horm.2002.1742
   Kasselman LJ, 2018, ATHEROSCLEROSIS, V271, P203, DOI 10.1016/j.atherosclerosis.2018.02.036
   Kato M, 2007, P NATL ACAD SCI USA, V104, P3432, DOI 10.1073/pnas.0611192104
   Kessler R, 2001, CHEST, V120, P369, DOI 10.1378/chest.120.2.369
   Khan UA, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071784
   Kidney Disease, 2013, Kidney Int Suppl, V3, P1, DOI DOI 10.1038/KISUP.2012.73
   Klop B, 2013, NUTRIENTS, V5, P1218, DOI 10.3390/nu5041218
   Kornblith LZ, 2015, J TRAUMA ACUTE CARE, V78, P30, DOI 10.1097/TA.0000000000000490
   Krishnan N, 2015, AM J TRANSPLANT, V15, P2378, DOI 10.1111/ajt.13363
   Kumari M, 2017, OBES REV, V18, P18, DOI 10.1111/obr.12484
   Kwakernaak AJ, 2013, J AM SOC NEPHROL, V24, P987, DOI 10.1681/ASN.2012050460
   Lau WL, 2015, NEPHRON, V130, P92, DOI 10.1159/000381990
   Lauby-Secretan B, 2016, NEW ENGL J MED, V375, P794, DOI 10.1056/NEJMsr1606602
   Lee YY, 2014, GUT, V63, P1053, DOI 10.1136/gutjnl-2013-305803
   Lentine KL, 2016, AM J TRANSPLANT, V16, P1848, DOI 10.1111/ajt.13687
   Ley RE, 2006, NATURE, V444, P1022, DOI 10.1038/4441022a
   Li-ying Chen, 2007, Journal of Zhejiang University-Science B, V8, P593, DOI 10.1631/jzus.2007.130593
   Lieske JC, 2015, KIDNEY INT, V87, P839, DOI 10.1038/ki.2014.352
   Logan AG, 2003, EUR RESPIR J, V21, P241, DOI 10.1183/09031936.03.00035402
   Manigrasso MR, 2005, J CLIN ENDOCR METAB, V90, P5876, DOI 10.1210/jc.2005-0281
   Mann JFE, 2008, LANCET, V372, P547, DOI 10.1016/S0140-6736(08)61236-2
   Mark AL, 2003, ACTA PHYSIOL SCAND, V177, P345, DOI 10.1046/j.1365-201X.2003.01085.x
   McMahon EJ, 2013, J AM SOC NEPHROL, V24, P2096, DOI 10.1681/ASN.2013030285
   Meier-Kriesche HU, 2002, TRANSPLANTATION, V73, P70, DOI 10.1097/00007890-200201150-00013
   MOORHEAD JF, 1982, LANCET, V2, P1309
   Morales E, 2003, AM J KIDNEY DIS, V41, P319, DOI 10.1053/ajkd.2003.50039
   Nagase M, 2006, J AM SOC NEPHROL, V17, P3438, DOI 10.1681/ASN.2006080944
   Naik AS, 2016, TRANSPLANTATION, V100, P1963, DOI 10.1097/TP.0000000000000983
   Nakayama T, 2010, AM J PHYSIOL-RENAL, V298, pF712, DOI 10.1152/ajprenal.00433.2009
   NEEL JV, 1962, AM J HUM GENET, V14, P353
   Neeland IJ, 2018, CIRCULATION, V137, P1391, DOI 10.1161/CIRCULATIONAHA.117.029617
   OLEFSKY JM, 1982, AM J PHYSIOL, V243, pE15, DOI 10.1152/ajpendo.1982.243.1.E15
   Olson AL, 2005, AM J MED, V118, P948, DOI 10.1016/j.amjmed.2005.03.042
   Ouchi N, 2000, CIRCULATION, V102, P1296, DOI 10.1161/01.CIR.102.11.1296
   Packer M, 2018, CIRCULATION, V137, P1614, DOI 10.1161/CIRCULATIONAHA.117.032474
   Peng YD, 2014, CELL SIGNAL, V26, P1888, DOI 10.1016/j.cellsig.2014.05.006
   Pothuraju R, 2018, ENDOCR METAB IMMUNE, V18, P212, DOI 10.2174/1871530318666180131092203
   Praga M, 2000, KIDNEY INT, V58, P2111, DOI 10.1046/j.1523-1755.2000.00384.x
   Praga M, 2002, NEPHROL DIAL TRANSPL, V17, P1157, DOI 10.1093/ndt/17.7.1157
   Pratt-Ubunama MN, 2007, CHEST, V131, P453, DOI 10.1378/chest.06-1442
   Putz DM, 2004, METABOLISM, V53, P1454, DOI 10.1016/j.metabol.2004.06.013
   Qaseem A, 2013, ANN INTERN MED, V159, P835, DOI 10.7326/0003-4819-159-12-201312170-00726
   Qian YJ, 2016, ARCH MED SCI, V12, P1077, DOI 10.5114/aoms.2016.61914
   Ramezani A, 2014, J AM SOC NEPHROL, V25, P657, DOI 10.1681/ASN.2013080905
   Rao BB, 2014, J NEPHROL, V27, P361, DOI 10.1007/s40620-014-0078-8
   Rayner DV, 2001, J MOL MED, V79, P8, DOI 10.1007/s001090100198
   Reisin E, 2001, AM J KIDNEY DIS, V38, P1129, DOI 10.1053/ajkd.2001.28620
   Remuzzi G, 1998, NEW ENGL J MED, V339, P1448, DOI 10.1056/NEJM199811123392007
   Remuzzi G, 2002, ANN INTERN MED, V136, P604, DOI 10.7326/0003-4819-136-8-200204160-00010
   Rocco MV, 2012, AM J KIDNEY DIS, V60, P857, DOI 10.1053/j.ajkd.2012.07.005
   ROCHESTER DF, 1974, AM J MED, V57, P402, DOI 10.1016/0002-9343(74)90135-1
   Sakaguchi Y, 2011, CLIN J AM SOC NEPHRO, V6, P995, DOI 10.2215/CJN.08670910
   Sarafidis PA, 2006, AM J NEPHROL, V26, P232, DOI 10.1159/000093632
   Saran R, 2018, AM J KIDNEY DIS, V71, pS1, DOI 10.1053/j.ajkd.2018.01.002
   Scherer PE, 2016, CIRC RES, V118, P1703, DOI 10.1161/CIRCRESAHA.116.308999
   Schiller JS., 2009, EARLY RELEASE SELECT
   Schmidt MI, 1996, METABOLISM, V45, P699, DOI 10.1016/S0026-0495(96)90134-1
   Schütten MTJ, 2017, PHYSIOLOGY, V32, P197, DOI 10.1152/physiol.00037.2016
   Sharma K, 2008, J CLIN INVEST, V118, P1645, DOI 10.1172/JCI32691
   Sharma K, 2009, KIDNEY INT, V76, P145, DOI 10.1038/ki.2009.137
   Shoham DA, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003431
   Sim JJ, 2011, J HYPERTENS, V29, P1553, DOI 10.1097/HJH.0b013e3283492219
   Singh AK, 2008, KIDNEY INT, V74, P438, DOI 10.1038/ki.2008.184
   Solas M, 2017, CURR OPIN PHARMACOL, V37, P87, DOI 10.1016/j.coph.2017.10.005
   Sowers JR, 2009, ANN INTERN MED, V150, P776, DOI 10.7326/0003-4819-150-11-200906020-00005
   Stenvinkel P, 2013, J AM SOC NEPHROL, V24, P1727, DOI 10.1681/ASN.2013040330
   Stern JH, 2016, CELL METAB, V23, P770, DOI 10.1016/j.cmet.2016.04.011
   Taylor EN, 2008, KIDNEY INT, V73, P207, DOI 10.1038/sj.ki.5002588
   Thijssen E, 2015, RHEUMATOLOGY, V54, P588, DOI 10.1093/rheumatology/keu464
   Torres-Fuentes C, 2017, LANCET GASTROENTEROL, V2, P747, DOI 10.1016/S2468-1253(17)30147-4
   Trayhurn P, 2004, BRIT J NUTR, V92, P347, DOI 10.1079/BJN20041213
   Trayhurn P, 2006, J NUTR, V136, p1935S, DOI 10.1093/jn/136.7.1935S
   Verbeke F, 2014, NEPHROL DIAL TRANSPL, V29, P490, DOI 10.1093/ndt/gft321
   White LH, 2015, J HUM HYPERTENS, V29, P342, DOI 10.1038/jhh.2014.94
   Wolf G, 1999, KIDNEY INT, V56, P860, DOI 10.1046/j.1523-1755.1999.00626.x
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yamauchi T, 2002, NAT MED, V8, P1288, DOI 10.1038/nm788
   Yang LR, 2016, CLIN EXP HYPERTENS, V38, P464, DOI 10.3109/10641963.2015.1131290
   Yoon MJ, 2006, DIABETES, V55, P2562, DOI 10.2337/db05-1322
   Yosipovitch G, 2007, J AM ACAD DERMATOL, V56, P901, DOI 10.1016/j.jaad.2006.12.004
   Young T, 2002, AM J RESP CRIT CARE, V165, P1217, DOI 10.1164/rccm.2109080
   Yusuf S, 2008, NEW ENGL J MED, V358, P1547, DOI 10.1056/NEJMoa0801317
   Zhang CH, 2015, EBIOMEDICINE, V2, P968, DOI 10.1016/j.ebiom.2015.07.007
   Zimmet P, 2001, NATURE, V414, P782, DOI 10.1038/414782a
NR 170
TC 115
Z9 126
U1 0
U2 15
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0033-0620
EI 1873-1740
J9 PROG CARDIOVASC DIS
JI Prog. Cardiovasc. Dis.
PD JUL-AUG
PY 2018
VL 61
IS 2
BP 157
EP 167
DI 10.1016/j.pcad.2018.07.005
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GU1VN
UT WOS:000445055400009
PM 29981350
DA 2025-06-11
ER

PT J
AU Nartea, R
   Mitoiu, BI
   Ghiorghiu, I
AF Nartea, Roxana
   Mitoiu, Brindusa Ilinca
   Ghiorghiu, Ioana
TI The Link between Magnesium Supplements and Statin Medication in
   Dyslipidemic Patients
SO CURRENT ISSUES IN MOLECULAR BIOLOGY
LA English
DT Review
DE magnesium supplements; metabolic syndrome; lipoproteins; statin
   medication; dyslipidemia
ID CHRONIC KIDNEY-DISEASE; CARDIOVASCULAR RISK-FACTORS; TYPE-2
   DIABETES-MELLITUS; METABOLIC SYNDROME; SERUM MAGNESIUM; DOUBLE-BLIND;
   INSULIN-RESISTANCE; DIETARY MAGNESIUM; OXIDATIVE STRESS; BLOOD-PRESSURE
AB Many investigations have discovered a connection between statins and magnesium supplements. On one hand, increasing research suggests that chronic hypomagnesemia may be an important factor in the etiology of some metabolic illnesses, including obesity and overweight, insulin resistance and type 2 diabetes mellitus, hypertension, alterations in lipid metabolism, and low-grade inflammation. Chronic metabolic problems seem to be prevented by a high Mg intake combined with diet and/or supplements. On the other hand, it is known that statins lower the frequency of cardiac events, stroke, and mortality, not by lowering LDL-C, but by the capacity to reduce mevalonate formation. That will enhance endothelial function, inhibit vascular smooth muscle cell proliferation and migration and encourage macrophages to promote plaque stability and regression while reducing inflammation. Taking these factors into consideration, we did an extensive analysis of the relevant literature, comparing the effects of Mg-2 and statin medications on lipoproteins and, implicitly, on the key enzymes involved in cholesterol metabolism.
C1 [Nartea, Roxana; Mitoiu, Brindusa Ilinca; Ghiorghiu, Ioana] Carol Davila Univ Med & Pharm, Clin Dept 9, Bucharest 050474, Romania.
   [Nartea, Roxana; Ghiorghiu, Ioana] Natl Inst Rehabil Phys Med & Balneoclimatol, Bucharest 030079, Romania.
   [Mitoiu, Brindusa Ilinca] Agrippa Ionescu Clin Emergency Hosp, Bucharest 077016, Romania.
C3 Carol Davila University of Medicine & Pharmacy
RP Mitoiu, BI (corresponding author), Carol Davila Univ Med & Pharm, Clin Dept 9, Bucharest 050474, Romania.; Mitoiu, BI (corresponding author), Agrippa Ionescu Clin Emergency Hosp, Bucharest 077016, Romania.
EM brindusa.mitoiu@umfcd.ro
RI Ilinca, Mitoiu/AAM-4216-2021; Ghiorghiu, Ioana/NBX-1940-2025; Nartea,
   Roxana/AAM-4176-2021
OI Nartea, Roxana/0000-0001-8132-0791; Ghiorghiu, Ioana/0009-0006-3357-5013
CR Ahmad WNHW, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0116867
   Ahmadian M, 2013, NAT MED, V19, P557, DOI 10.1038/nm.3159
   Akyüz O, 2022, BIOL TRACE ELEM RES, V200, P3070, DOI 10.1007/s12011-021-02922-9
   Al Alawi AM, 2018, INT J ENDOCRINOL, V2018, DOI 10.1155/2018/9041694
   Alkazemi D, 2022, NUTRIENTS, V14, DOI 10.3390/nu14245257
   Altabas V, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23052663
   Altura BM, 2010, AM J PHYSIOL-HEART C, V299, pH932, DOI 10.1152/ajpheart.01076.2009
   Asbaghi O, 2021, BIOL TRACE ELEM RES, V199, P861, DOI 10.1007/s12011-020-02209-5
   Attardo S, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23158364
   Aygun S, 2022, J CLIN MED, V11, DOI 10.3390/jcm11237249
   Bain LKM, 2015, INT J CARDIOL, V196, P108, DOI 10.1016/j.ijcard.2015.05.166
   Bansal A B., 2022, HMG-CoA Reductase Inhibitors. StatPearls
   Barakat Lolwa, 2013, ISRN Pharmacol, V2013, P146579, DOI 10.1155/2013/146579
   Barbagallo M, 2007, ARCH BIOCHEM BIOPHYS, V458, P40, DOI 10.1016/j.abb.2006.05.007
   Barbagallo M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020463
   Barbagallo Mario, 2003, Molecular Aspects of Medicine, V24, P39, DOI 10.1016/S0098-2997(02)00090-0
   Benford D, 2015, EFSA J, V13, DOI 10.2903/j.efsa.2015.4140
   Bikle DD., 2021, VITAMIN D PRODUCTION
   Birrane G, 2019, P NATL ACAD SCI USA, V116, P1723, DOI 10.1073/pnas.1817984116
   Björkegren J, 1998, J LIPID RES, V39, P1412
   Borges RD, 2020, ARCH ENDOCRIN METAB, V64, P639, DOI 10.20945/2359-3997000000306
   Buettner Catherine, 2016, J Nat Sci, V2
   Cambray S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12092631
   Castellanos-Gutiérrez A, 2018, NUTR J, V17, DOI 10.1186/s12937-018-0422-2
   Cheon DY., 2022, Cardiovasc Prev Pharmacother, V4, P1, DOI [10.36011/cpp.2022.4.e4, DOI 10.36011/CPP.2022.4.E4]
   Cruz KJC, 2014, BIOL TRACE ELEM RES, V160, P305, DOI 10.1007/s12011-014-0044-2
   Climent E, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.687585
   Costello RB, 2016, ADV NUTR, V7, P977, DOI 10.3945/an.116.012765
   Cunha AR, 2017, J HYPERTENS, V35, P89, DOI 10.1097/HJH.0000000000001129
   Dai BY, 2021, BIOACT MATER, V6, P2511, DOI 10.1016/j.bioactmat.2021.01.027
   Das KC, 2022, BIOMED RES INT, V2022, DOI 10.1155/2022/4558867
   Dey R, 2015, CLIN EXP NEPHROL, V19, P1054, DOI 10.1007/s10157-015-1097-z
   Dibaba DT, 2021, CLIN NUTR, V40, P2337, DOI 10.1016/j.clnu.2020.10.024
   DiNicolantonio JJ, 2018, OPEN HEART, V5, DOI 10.1136/openhrt-2017-000668
   Dominguez LJ, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010125
   Dominguez LJ, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010139
   dos Santos LR, 2021, BIOL TRACE ELEM RES, V199, P4020, DOI 10.1007/s12011-020-02528-7
   Duan YJ, 2022, SIGNAL TRANSDUCT TAR, V7, DOI 10.1038/s41392-022-01125-5
   Dzobo Kim E, 2021, Immunometabolism, V3, pe210020, DOI 10.20900/immunometab20210020
   El-Haggar SM, 2014, BRIT J PHARM RES, V4, P1521, DOI 10.9734/BJPR/2014/11145
   Elfaki I, 2021, CURR ISSUES MOL BIOL, V43, P1859, DOI 10.3390/cimb43030130
   Farshidi H, 2020, J CARDIOVASC PHARM, V76, P321, DOI 10.1097/FJC.0000000000000874
   Flores-Dorantes MT, 2020, FRONT NEUROSCI-SWITZ, V14, DOI 10.3389/fnins.2020.00863
   Fong CW, 2014, EUR J MED CHEM, V85, P661, DOI 10.1016/j.ejmech.2014.08.037
   Formanowicz D, 2022, BIOLOGY-BASEL, V11, DOI 10.3390/biology11030430
   Freeman LA, 2020, CURR OPIN LIPIDOL, V31, P71, DOI 10.1097/MOL.0000000000000673
   Friesen JA, 2004, GENOME BIOL, V5, DOI 10.1186/gb-2004-5-11-248
   Fung TT, 2003, J AM COLL NUTR, V22, P533, DOI 10.1080/07315724.2003.10719332
   Galicia-Garcia U, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21134725
   George RT, 2021, J AM HEART ASSOC, V10, DOI 10.1161/JAHA.119.014572
   Gheorghe G, 2020, DIAGNOSTICS, V10, DOI 10.3390/diagnostics10070483
   Gillard BK, 2009, BBA-MOL CELL BIOL L, V1791, P1125, DOI 10.1016/j.bbalip.2009.07.004
   Gordon S.M., 2014, The HDL Handbook, VSecond, P293, DOI DOI 10.1016/B978-0-12-407867-3.00012-3
   Grosskopf I, 2005, ARTERIOSCL THROM VAS, V25, P2573, DOI 10.1161/01.ATV.0000186189.26141.12
   Guerrero-Romero F, 2002, ACTA DIABETOL, V39, P209, DOI 10.1007/s005920200036
   Guerrero-Romero F, 2000, J DIABETES COMPLICAT, V14, P272, DOI 10.1016/S1056-8727(00)00127-6
   Guerrero-Romero F, 2016, MAGNESIUM RES, V29, P146, DOI 10.1684/mrh.2016.0404
   Guerrini V, 2019, TRENDS IMMUNOL, V40, P1163, DOI 10.1016/j.it.2019.10.002
   Gui YJ, 2017, EUR J PREV CARDIOL, V24, P907, DOI 10.1177/2047487317691874
   Ham JY, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020515
   Hamedifard Z, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-01298-4
   He CW, 2018, CELL METAB, V27, P1055, DOI 10.1016/j.cmet.2018.03.017
   He K, 2006, CIRCULATION, V113, P1675, DOI 10.1161/CIRCULATIONAHA.105.588327
   Humphries S, 1999, AM J HYPERTENS, V12, P747, DOI 10.1016/S0895-7061(99)00041-2
   Hyun MH, 2019, CARDIOVASC THER, V2019, DOI 10.1155/2019/3824823
   Ibrahim S, 2022, REP BIOCHEM MOL BIOL, V11, P350, DOI 10.52547/rbmb.11.2.350
   Ismail AAA, 2018, QJM-INT J MED, V111, P759, DOI 10.1093/qjmed/hcx186
   Itoh K, 1997, BRIT J NUTR, V78, P737, DOI 10.1079/BJN19970191
   Jacobs DR Jr, 2022, NEW ENGL J MED, V386, P1877, DOI 10.1056/NEJMoa2109191
   Jamilian M, 2017, MAGNESIUM RES, V30, P71, DOI 10.1684/mrh.2017.0425
   Jebari-Benslaiman S, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23063346
   Jiao YY, 2022, NUTRIENTS, V14, DOI 10.3390/nu14102013
   Jin HF, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111760
   Jin SS, 2021, BRIT J NUTR, V126, P892, DOI 10.1017/S0007114520004754
   Joris PJ, 2016, ATHEROSCLEROSIS, V252, pE90, DOI 10.1016/j.atherosclerosis.2016.07.533
   Kamal Sahar Mohamed, 2011, J Exp Pharmacol, V3, P51, DOI 10.2147/JEP.S19449
   Karie S, 2006, PRESSE MED, V35, P219, DOI 10.1016/S0755-4982(06)74557-2
   Khan SA, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24021353
   Klop B, 2013, NUTRIENTS, V5, P1218, DOI 10.3390/nu5041218
   Kontush A, 2006, NAT CLIN PRACT CARD, V3, P144, DOI 10.1038/ncpcardio0500
   Koushki K, 2021, CLIN REV ALLERG IMMU, V60, P175, DOI 10.1007/s12016-020-08791-9
   Kristensen KK, 2020, P NATL ACAD SCI USA, V117, P4337, DOI 10.1073/pnas.1920202117
   Kuklenyik Z, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194797
   Kumari A, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9070782
   Kunnen S, 2012, J LIPID RES, V53, P1783, DOI 10.1194/jlr.R024513
   Larsson SC, 2018, BMC MED, V16, DOI 10.1186/s12916-018-1065-z
   Lee HY, 2013, PEDIATR CARDIOL, V34, P1396, DOI 10.1007/s00246-013-0658-8
   Lee K, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0269301
   Lee OS, 2018, PULSE, V6, P19, DOI 10.1159/000485659
   Leth-Espensen KZ, 2021, P NATL ACAD SCI USA, V118, DOI 10.1073/pnas.2026650118
   Li SX, 2003, JAMA-J AM MED ASSOC, V290, P2271, DOI 10.1001/jama.290.17.2271
   Li XL, 2020, DIABET METAB SYND OB, V13, P3645, DOI 10.2147/DMSO.S265735
   Libby P, 2019, NAT REV DIS PRIMERS, V5, DOI [10.1038/s41572-019-0106-z, 10.1038/s41572-019-0116-x]
   Lobionda S, 2019, MICROORGANISMS, V7, DOI 10.3390/microorganisms7080271
   Lookene A, 2005, J BIOL CHEM, V280, P25383, DOI 10.1074/jbc.M501589200
   Lopez-Ridaura R, 2004, DIABETES CARE, V27, P134, DOI 10.2337/diacare.27.1.134
   Mahalle Namita, 2012, J Cardiovasc Dis Res, V3, P280, DOI 10.4103/0975-3583.102698
   Maier JA, 2021, SEMIN CELL DEV BIOL, V115, P37, DOI 10.1016/j.semcdb.2020.11.002
   Manna P, 2015, METAB SYNDR RELAT D, V13, P423, DOI 10.1089/met.2015.0095
   Mehta R, 2021, LIPIDS HEALTH DIS, V20, DOI 10.1186/s12944-021-01498-6
   Mir R, 2022, LIFE-BASEL, V12, DOI 10.3390/life12111905
   Mishra S, 2012, BIOMED RES-INDIA, V23, P295
   Mousavi SE, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-03915-3
   Nanna MG, 2019, CIRC-CARDIOVASC QUAL, V12, DOI 10.1161/CIRCOUTCOMES.118.005562
   Nesto Richard W, 2005, Am J Cardiovasc Drugs, V5, P379, DOI 10.2165/00129784-200505060-00005
   Newman CB, 2019, ARTERIOSCL THROM VAS, V39, pE38, DOI 10.1161/ATV.0000000000000073
   Nordestgaard BG, 2016, J LIPID RES, V57, P1953, DOI 10.1194/jlr.R071233
   O'Brien PJ, 2005, CLIN CHEM, V51, P351, DOI 10.1373/clinchem.2004.040824
   Oldoni F, 2018, CIRCULATION, V138, P1000, DOI 10.1161/CIRCULATIONAHA.118.034706
   Ossoli A, 2019, ARTERIOSCL THROM VAS, V39, P915, DOI 10.1161/ATVBAHA.118.311987
   Ossoli A, 2016, ENDOCRINOL METAB, V31, P223, DOI 10.3803/EnM.2016.31.2.223
   Otelea MR, 2022, CURR ISSUES MOL BIOL, V44, P2646, DOI 10.3390/cimb44060181
   Padam P, 2022, OPEN HEART, V9, DOI 10.1136/openhrt-2022-002184
   Pedrelli M, 2021, J LIPID RES, V62, DOI 10.1016/j.jlr.2021.100065
   Pelczynska M, 2022, NUTRIENTS, V14, DOI 10.3390/nu14091714
   Perego C, 2019, BBA-MOL BASIS DIS, V1865, P2149, DOI 10.1016/j.bbadis.2019.04.012
   Peters SAE, 2018, J AM COLL CARDIOL, V71, P1729, DOI 10.1016/j.jacc.2018.02.032
   Pinal-Fernandez I, 2018, MED CLIN-BARCELONA, V150, P398, DOI [10.1016/j.medcle.2018.03.001, 10.1016/j.medcli.2017.11.030]
   Pirahanchi Y, 2022, STATPEARLS
   Powell-Wiley TM, 2021, CIRCULATION, V143, pE984, DOI 10.1161/CIR.0000000000000973
   Raitakari O, 2023, CIRCULATION, V147, P23, DOI 10.1161/CIRCULATIONAHA.122.060667
   Ramkumar S, 2016, ACTA CARDIOL SIN, V32, P631, DOI 10.6515/ACS20160611A
   Randell EW, 2008, ATHEROSCLEROSIS, V196, P413, DOI 10.1016/j.atherosclerosis.2006.11.024
   Rasheed H, 2012, BIOL TRACE ELEM RES, V148, P165, DOI 10.1007/s12011-012-9361-5
   Rashvand S, 2020, BIOL TRACE ELEM RES, V194, P328, DOI 10.1007/s12011-019-01802-7
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   Rodríguez-Morán M, 2018, ADV CHRONIC KIDNEY D, V25, P261, DOI 10.1053/j.ackd.2018.02.011
   Rosanoff A, 2004, J AM COLL NUTR, V23, p501S, DOI 10.1080/07315724.2004.10719389
   Rosanoff Andrea, 2005, Clin Calcium, V15, P255
   Rosanoff A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010195
   Rosenson RS, 2015, CARDIOVASC DRUG THER, V29, P41, DOI 10.1007/s10557-014-6567-0
   Rossini E, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23169326
   Rotariu D, 2022, BIOMED PHARMACOTHER, V152, DOI 10.1016/j.biopha.2022.113238
   Rotter I, 2015, MAGNESIUM RES, V28, P99, DOI 10.1684/mrh.2015.0391
   Saeedi R, 2015, CLIN BIOCHEM, V48, P472, DOI 10.1016/j.clinbiochem.2014.08.014
   Salehidoost R, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-20277-6
   Schmidt K, 2016, J LIPID RES, V57, P1339, DOI 10.1194/jlr.R067314
   Selva-O'Callaghan A, 2018, EXPERT REV CLIN IMMU, V14, P215, DOI 10.1080/1744666X.2018.1440206
   Shahbah D, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000005166
   Shen WJ, 2018, ANNU REV PHYSIOL, V80, P95, DOI 10.1146/annurev-physiol-021317-121550
   Shu X, 2022, NUTRIENTS, V14, DOI 10.3390/nu14204365
   Morais JBS, 2017, BIOL TRACE ELEM RES, V176, P20, DOI 10.1007/s12011-016-0793-1
   Simental-Mendía LE, 2017, EUR J CLIN PHARMACOL, V73, P525, DOI 10.1007/s00228-017-2212-8
   Simental-Mendía LE, 2016, PHARMACOL RES, V111, P272, DOI 10.1016/j.phrs.2016.06.019
   Singh S, 2022, ENVIRON SCI POLLUT R, V29, P76514, DOI 10.1007/s11356-022-23043-3
   Sizar O., 2022, STATIN MEDICATIONS
   Skoczynska A, 2016, ARCH MED SCI, V12, P704, DOI 10.5114/aoms.2016.60950
   de Oliveira ARS, 2017, REV ASSOC MED BRAS, V63, P156, DOI 10.1590/1806-9282.63.02.156
   Son M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0083496
   Song Y, 2006, DIABETIC MED, V23, P1050, DOI 10.1111/j.1464-5491.2006.01852.x
   Song YQ, 2004, DIABETES CARE, V27, P59, DOI 10.2337/diacare.27.1.59
   Song YQ, 2005, DIABETES CARE, V28, P1438, DOI 10.2337/diacare.28.6.1438
   Suliburska J, 2013, EUR REV MED PHARMACO, V17, P2396
   Sundaram M, 2010, NUTR METAB, V7, DOI 10.1186/1743-7075-7-35
   Sung SE, 2021, BMC GASTROENTEROL, V21, DOI 10.1186/s12876-021-01704-w
   Theofilis P, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9070781
   Thongtang N, 2017, J DIABETES METAB DIS, V16, DOI 10.1186/s40200-017-0290-x
   Toprak O, 2017, CLIN INTERV AGING, V12, P437, DOI 10.2147/CIA.S129377
   Torres PA, 2015, OCHSNER J, V15, P58
   Tsimikas S, 2020, NEW ENGL J MED, V382, P244, DOI 10.1056/NEJMoa1905239
   Tsimikas S, 2018, J AM COLL CARDIOL, V71, P177, DOI 10.1016/j.jacc.2017.11.014
   Verma H, 2017, J HUM NUTR DIET, V30, P621, DOI 10.1111/jhn.12454
   Veronese N, 2022, NUTRIENTS, V14, DOI 10.3390/nu14030679
   Vesa CM, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24044029
   Viney NJ, 2018, J CLIN LIPIDOL, V12, P702, DOI 10.1016/j.jacl.2018.02.014
   Vogt L, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.118.010827
   Ward NC, 2019, CIRC RES, V124, P328, DOI 10.1161/CIRCRESAHA.118.312782
   Weil PA., 2016, HARPERS ILLUSTRATED
   Williams KJ, 2010, CURR OPIN LIPIDOL, V21, P218, DOI 10.1097/MOL.0b013e328338cabc
   Wilson DP, 2021, CURR OPIN ENDOCRINOL, V28, P159, DOI 10.1097/MED.0000000000000624
   Yamori Y, 2015, HYPERTENS RES, V38, P219, DOI 10.1038/hr.2014.158
   Yang N, 2020, DIABET METAB SYND OB, V13, P2541, DOI 10.2147/DMSO.S257884
   Yeang C, 2021, J LIPID RES, V62, DOI 10.1016/j.jlr.2021.100053
   Yu LL, 2018, BRIT J NUTR, V120, P250, DOI 10.1017/S0007114518000685
   Yuan ZP, 2016, ANN NUTR METAB, V69, P125, DOI 10.1159/000450761
   Zhang Q, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0815-4
   Zhao L, 2021, RENAL FAILURE, V43, P718, DOI 10.1080/0886022X.2021.1915799
   Zheltova AA, 2016, BIOMEDICINE-TAIWAN, V6, P8, DOI 10.7603/s40681-016-0020-6
   Zhu YH, 2018, BIOMOLECULES, V8, DOI 10.3390/biom8030080
NR 179
TC 10
Z9 10
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1467-3037
EI 1467-3045
J9 CURR ISSUES MOL BIOL
JI Curr. Issues Mol. Biol.
PD APR
PY 2023
VL 45
IS 4
BP 3146
EP 3167
DI 10.3390/cimb45040205
PG 22
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA F5ZH8
UT WOS:000983120800001
PM 37185729
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Taneja, SK
   Jain, M
   Mandal, R
   Megha, K
AF Taneja, Satish Kumar
   Jain, Mridula
   Mandal, Reshu
   Megha, Kirti
TI Excessive zinc in diet induces leptin resistance in Wistar rat through
   increased uptake of nutrients at intestinal level
SO JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
LA English
DT Article
DE Zinc; Leptin; Insulin; Rat; Intestine
ID METABOLIC SYNDROME-X; PLASMA LEPTIN; OXIDATIVE STRESS; FOOD-INTAKE;
   OBESE; INSULIN; WEIGHT; SUPPLEMENTATION; ENDOCRINE; PHYTATE
AB Project: The ob gene has either been found to be mutant defective resulting in a deficiency of its product leptin or leptin has been found to be resistant to its receptors in obese human and rodents. The factors inducing leptin resistance have not been identified. Since excessive bioavailability of Zn has been implicated in obesity, we investigated if its excess in diet induces leptin resistance.
   Procedure: For the investigations, three groups of Wistar rats were included in this study and they were fed on equicalories semi synthetic basal diet containing 20 mg, 40 mg or 80 mg Zn/kg diet for 120 days. There after they were sacrificed for hormonal status and intestinal investigations.
   Results: The data of this study revealed that the food intake, gain in body weight, serum leptin, glucose, insulin, cortisol increased with increased Zn concentration in diet. TEM study showed a positive correlation between Zn concentration in diet and number of microvilli/unit surface area of the mucosal epithelial cells of the intestine.
   Conclusion: The results of this study suggest that excessive bioavailability of Zn induces leptin resistance through increased uptake of nutrients at intestinal level, leading to the growth of the fat cells which aggravated the leptin synthesis and its release in the blood stream. In spite of its higher circulating level, it was unable to reduce the food intake and gain in body weight in Zn treated rats equivalent to the control group. (C) 2012 Elsevier GmbH. All rights reserved.
C1 [Taneja, Satish Kumar; Jain, Mridula; Mandal, Reshu; Megha, Kirti] Panjab Univ, Dept Zool, Chandigarh 160014, India.
C3 Panjab University
RP Taneja, SK (corresponding author), Panjab Univ, Dept Zool, Chandigarh 160014, India.
EM sktaneja@gmail.com
RI megha, kirti/AAD-2765-2022
OI Megha, Kirti/0000-0001-8830-7987
FU Emeritus Fellowship; University Grant Commission
FX Authors are thankful to Prof. Neelima R. Kumar Chairperson of the
   Department of Zoology, Panjab University Chandigarh for providing
   Laboratory facilities and All India Institute of Medical Sciences (New
   Delhi, India) for Transmission Electron Microscopy. The Emeritus
   Fellowship provided to the senior author Prof. S.K. Taneja by University
   Grant Commission is gratefully acknowledged.
CR [Anonymous], BIOL TRACE ELEM RES
   Barr VB, 1997, ENDROCRINOLOGY, V138, P530
   Blum WF, 1997, J CLIN ENDOCR METAB, V82, P2904, DOI 10.1210/jc.82.9.2904
   Boehm TM, 1979, DIABETES CARE, V52, P490
   CAMPFIELD LA, 1995, SCIENCE, V269, P546, DOI 10.1126/science.7624778
   Caro JF, 1996, LANCET, V348, P159, DOI 10.1016/S0140-6736(96)03173-X
   Collect AJ, 1979, J HISTOCHEM CYTOCHEM, V28, P989
   Considine RV, 1996, NEW ENGL J MED, V334, P292, DOI 10.1056/NEJM199602013340503
   Fraser R, 1999, HYPERTENSION, V33, P1364, DOI 10.1161/01.HYP.33.6.1364
   Friedman JM, 1998, NATURE, V395, P763, DOI 10.1038/27376
   Gu W, 1999, CHIN J ENDOCRIONOL M, V15, P15
   Kelishadi R, 2010, METAB SYNDR RELAT D, V8, P505, DOI 10.1089/met.2010.0020
   Konukoglu D, 2004, J NUTR BIOCHEM, V15, P757, DOI 10.1016/j.jnutbio.2004.07.007
   KOO SI, 1977, J NUTR, V107, P909, DOI 10.1093/jn/107.5.909
   MAFFEI M, 1995, NAT MED, V1, P1155, DOI 10.1038/nm1195-1155
   Mantzoros CS, 1996, DIABETES, V45, P909, DOI 10.2337/diabetes.45.7.909
   Marreiro DD, 2006, BIOL TRACE ELEM RES, V112, P109, DOI 10.1385/BTER:112:2:109
   Mohn A, 2004, ITAL J PEDIATR, V30, P218
   MORAN JR, 1985, LIFE SCI, V36, P2515, DOI 10.1016/0024-3205(85)90148-1
   Morton GJ, 2006, NATURE, V443, P289, DOI 10.1038/nature05026
   Niki T, 1996, DIABETES, V45, P675, DOI 10.2337/diabetes.45.5.675
   OBERLEAS D, 1981, J AM DIET ASSOC, V79, P433
   ORGEBINCRIST MC, 1971, ANN BIOL ANIM BIOCH, V11, P547, DOI 10.1051/rnd:19710403
   PASQUALI R, 1993, J CLIN ENDOCR METAB, V77, P341, DOI 10.1210/jc.77.2.341
   POMP D, 1992, Journal of Animal Science, V70, P198
   Pomp D, 1996, TRANSGENIC RES, V5, P13, DOI 10.1007/BF01979918
   PRENTICE A, 1993, NUTR REV, V51, P268, DOI 10.1111/j.1753-4887.1993.tb03118.x
   Remesar X, 1997, FEBS LETT, V402, P9, DOI 10.1016/S0014-5793(96)01477-9
   Robinson CJ, 2001, J MOL ENDOCRINOL, V27, P69, DOI 10.1677/jme.0.0270069
   Rosmond R, 1998, J CLIN ENDOCR METAB, V83, P1853, DOI 10.1210/jc.83.6.1853
   Sacks BD, 1994, TIETZ TXB CLIN CHEM, P959
   Tall AR, 2004, NEW ENGL J MED, V350, P1450, DOI 10.1056/NEJMe048020
   Tallman DL, 2003, J NUTR BIOCHEM, V14, P17, DOI 10.1016/S0955-2863(02)00228-0
   Taneja S. K., 2006, Indian Journal of Experimental Biology, V44, P705
   Taneja SK, 2009, INDIAN J EXP BIOL, V47, P104
   TANEJA SK, 1992, BRIT J NUTR, V68, P505, DOI 10.1079/BJN19920108
   Taneja SK, 1996, EXPERIENTIA, V52, P31, DOI 10.1007/BF01922412
   Tietz N W., 1976, Clinical guide to laboratory tests
   Trayhurn P, 2001, P NUTR SOC, V60, P329, DOI 10.1079/PNS200194
   Trinder P., 1969, Journal of Clinical Pathology, V22, P158, DOI 10.1136/jcp.22.2.158
   TURNLUND JR, 1984, AM J CLIN NUTR, V40, P1071, DOI 10.1093/ajcn/40.5.1071
   Ur E, 1996, HORM METAB RES, V28, P744, DOI 10.1055/s-2007-979891
   Zakrzewska KE, 1997, DIABETES, V46, P717, DOI 10.2337/diabetes.46.4.717
   ZHANG YY, 1994, NATURE, V372, P425, DOI 10.1038/372425a0
NR 44
TC 23
Z9 25
U1 0
U2 1
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0946-672X
J9 J TRACE ELEM MED BIO
JI J. Trace Elem. Med. Biol.
PY 2012
VL 26
IS 4
BP 267
EP 272
DI 10.1016/j.jtemb.2012.03.002
PG 6
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 059EL
UT WOS:000312687100009
PM 22683053
DA 2025-06-11
ER

PT J
AU Katsiki, N
   Athyros, VG
   Karagiannis, A
   Mikhailidis, DP
AF Katsiki, Niki
   Athyros, Vasilios G.
   Karagiannis, Asterios
   Mikhailidis, Dimitri P.
TI The Role of Statins in the Treatment of Type 2 Diabetes Mellitus: An
   Update
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Type 2 diabetes mellitus; dyslipidemia; statin; cardiovascular risk
ID CORONARY-HEART-DISEASE; DENSITY-LIPOPROTEIN-CHOLESTEROL; OBSTRUCTIVE
   SLEEP-APNEA; LOWERING TREATMENT STRATEGIES; CARDIOVASCULAR END-POINTS;
   POST-HOC ANALYSIS; URIC-ACID LEVELS; METABOLIC SYNDROME; GREEK
   ATORVASTATIN; PRIMARY PREVENTION
AB The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide. T2DM is associated with both microvascular (neuropathy, nephropathy and retinopathy) and macrovascular complications [coronary artery disease (CAD), stroke, carotid artery disease and peripheral artery disease (PAD)].
   Apart from acting on diabetic dyslipidemia, statins were shown to exert beneficial effects on several diabetic complications as well as other cardiovascular (CVD) risk predictors such as endothelial dysfunction, inflammation, oxidative stress, chronic kidney disease (CKD), non-alcoholic fatty liver disease (NAFLD), metabolic syndrome (MetS), obstructive sleep apnea syndrome (OSAS) and hyperuricemia.
   Several clinical trials involving T2DM patients have reported significant reductions in coronary and cerebrovascular events following statin treatment. However, a modest statin-related risk of new-onset diabetes (NOD) has been reported but that did outweigh the benefit of CVD risk reduction in high-risk individuals.
   Overall, statin use is beneficial and should be recommended in diabetic patients to target their increased CVD risk.
C1 [Katsiki, Niki; Athyros, Vasilios G.; Karagiannis, Asterios] Aristotle Univ Thessaloniki, Sch Med, Hippocrat Hosp, Propedeut Dept Internal Med 2, GR-54006 Thessaloniki, Greece.
   [Mikhailidis, Dimitri P.] UCL, Univ Coll London Med Sch, Dept Clin Biochem, Vasc Dis Prevent Clinic, London NW3 2QG, England.
   [Mikhailidis, Dimitri P.] UCL, Univ Coll London Med Sch, Dept Surg, London NW3 2QG, England.
C3 Aristotle University of Thessaloniki; University of London; University
   College London; University of London; University College London
RP Mikhailidis, DP (corresponding author), UCL, Univ Coll Med Sch, Royal Free Hosp Campus, Dept Clin Biochem, Pond St, London NW3 2QG, England.
EM MIKHAILIDIS@aol.com
RI Mikhailidis, Dimitri/A-1869-2013; Athyros, V.G./H-5328-2019; KATSIKI,
   NIKI/ADE-7999-2022
OI KATSIKI, NIKI/0000-0003-0894-2644
CR Abbate M, 2011, CURR DIABETES REV, V7, P190, DOI 10.2174/157339911795843168
   Abe M, 2011, J ATHEROSCLER THROMB, V18, P1018
   Abel T, 2009, MED SCI MONITOR, V15, pMS6
   Anfossi G, 2010, CURR VASC PHARMACOL, V8, P327, DOI 10.2174/157016110791112359
   [Anonymous], NEW ENGL J MED
   [Anonymous], J ATHEROSCLER THROMB
   [Anonymous], 2013, Diabetes Care
   [Anonymous], CURR PHARM DES
   [Anonymous], CURR PHARM IN PRESS
   [Anonymous], J CARDIOVASC MED HAG
   [Anonymous], NUTR METAB CARDIOVAS
   [Anonymous], CARDIOVASC THER
   [Anonymous], CURR VASC PHARM
   [Anonymous], CURR PHARM DES
   [Anonymous], INT J CARDIOL
   [Anonymous], DRUGS
   [Anonymous], CURR MED RES OPIN
   [Anonymous], HEART VESSELS
   [Anonymous], EUR J CLIN PHARM
   [Anonymous], CURR MED RES OPIN
   [Anonymous], OBESITY
   [Anonymous], EUR J PREV CARD 0530
   [Anonymous], EUR J PREV CARD 1112
   [Anonymous], CURR PHARM DES
   [Anonymous], CURR VASC PHARM
   [Anonymous], AM J CARDIOL
   [Anonymous], CURR PHARM DES
   [Anonymous], CURR PHARM DES
   Arca M, 2012, CURR VASC PHARMACOL, V10, P684, DOI 10.2174/157016112803520864
   Athyros VG, 2007, NEPHROL DIAL TRANSPL, V22, P118, DOI 10.1093/ndt/gfl538
   Athyros VG, 2012, J CARDIOVASC MED, V13, P254, DOI 10.2459/JCM.0b013e3283522422
   Athyros VG, 2011, OPEN CARDIOVASC MED, V5, P226, DOI 10.2174/1874192401105010226
   Athyros Vasilios G, 2011, Open Cardiovasc Med J, V5, P24, DOI 10.2174/1874192401105010024
   Athyros VG, 2010, LANCET, V376, P1916, DOI 10.1016/S0140-6736(10)61272-X
   Athyros VG, 2010, EXPERT OPIN PHARMACO, V11, P723, DOI 10.1517/14656560903575654
   Athyros VG, 2012, NAT REV ENDOCRINOL, V8, P133, DOI 10.1038/nrendo.2012.16
   Athyros VG, 2011, ARCH MED SCI, V7, P796, DOI 10.5114/aoms.2011.25554
   Athyros VG, 2011, CURR MED RES OPIN, V27, P1659, DOI 10.1185/03007995.2011.595782
   Athyros VG, 2003, ANGIOLOGY, V54, P679, DOI 10.1177/000331970305400607
   Athyros VG, 2004, J CLIN PATHOL, V57, P728, DOI 10.1136/jcp.2003.012989
   Baigent C, 2011, LANCET, V377, P2181, DOI 10.1016/S0140-6736(11)60739-3
   Barakat Lolwa, 2013, ISRN Pharmacol, V2013, P146579, DOI 10.1155/2013/146579
   Bell DSH, 2012, DIABETES OBES METAB, V14, P299, DOI 10.1111/j.1463-1326.2011.01519.x
   Bianchi C, 2011, NUTR METAB CARDIOVAS, V21, P699, DOI 10.1016/j.numecd.2010.03.006
   Briasoulis A, 2013, J CLIN HYPERTENS, V15, P310, DOI 10.1111/jch.12081
   Callahan A, 2011, ARCH NEUROL-CHICAGO, V68, P1245, DOI 10.1001/archneurol.2011.146
   Cannon CP, 2010, NEW ENGL J MED, V363, P2406, DOI 10.1056/NEJMoa1009744
   Carter AA, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f2610
   Ceriello A, 2007, J DIABETES COMPLICAT, V21, P20, DOI 10.1016/j.jdiacomp.2005.11.005
   Chandni R, 2012, WORLD J DIABETES, V3, P105, DOI 10.4239/wjd.v3.i5.105
   Chaudhuri A, 2011, DIABETES OBES METAB, V13, P869, DOI 10.1111/j.1463-1326.2011.01423.x
   Chei CL, 2013, STROKE, V44, P327, DOI 10.1161/STROKEAHA.112.674812
   Chew EY, 2010, NEW ENGL J MED, V363, P233, DOI 10.1056/NEJMoa1001288
   Colbert JD, 2012, CAN J CARDIOL, V28, P581, DOI 10.1016/j.cjca.2012.03.021
   Colhoun HM, 2009, AM J KIDNEY DIS, V54, P810, DOI 10.1053/j.ajkd.2009.03.022
   Colhoun HM, 2004, LANCET, V364, P685, DOI 10.1016/S0140-6736(04)16895-5
   Collins R, 2003, LANCET, V361, P2005
   Cuccurullo C, 2006, ARTERIOSCL THROM VAS, V26, P2716, DOI 10.1161/01.ATV.0000249630.02085.12
   Culver AL, 2012, ARCH INTERN MED, V172, P144, DOI 10.1001/archinternmed.2011.625
   Cushman WC, 2010, NEW ENGL J MED, V362, P1575, DOI 10.1056/NEJMoa1001286
   Daida H, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-87
   Davis TME, 2008, DIABETOLOGIA, V51, P562, DOI 10.1007/s00125-007-0919-2
   de Vries FM, 2012, DRUGS, V72, P2365, DOI 10.2165/11638240-000000000-00000
   Drager LF, 2011, CHEST, V140, P534, DOI 10.1378/chest.10-2223
   Duckworth W, 2009, NEW ENGL J MED, V360, P129, DOI 10.1056/NEJMoa0808431
   Durrington PN, 2004, DIABETES RES CLIN PR, V64, P137, DOI 10.1016/j.diabres.2003.11.012
   Enkhmaa B, 2010, CURR DIABETES REP, V10, P61, DOI 10.1007/s11892-009-0088-4
   Farbstein D, 2012, EXPERT REV CARDIOVAS, V10, P353, DOI [10.1586/ERC.11.182, 10.1586/erc.11.182]
   Feher M, 2013, DIABETES METAB SYNDR, V6, P11, DOI 10.2147/DMSO.S35053
   Fellström BC, 2009, NEW ENGL J MED, V360, P1395, DOI 10.1056/NEJMoa0810177
   Fisher EA, 2012, ARTERIOSCL THROM VAS, V32, P2813, DOI 10.1161/ATVBAHA.112.300133
   Florentin M, 2011, CURR VASC PHARMACOL, V9, P385, DOI 10.2174/157016111796197279
   Fox KM, 2007, CURR MED RES OPIN, V23, P2125, DOI 10.1185/030079907X219580
   Gazi IF, 2006, DIABETES CARE, V29, P2561, DOI 10.2337/dc06-1487
   Gelsinger C, 2012, DRUGS, V72, P1445, DOI 10.2165/11635060-000000000-00000
   Gerstein HC, 2008, NEW ENGL J MED, V358, P2545, DOI 10.1056/NEJMoa0802743
   Goldberg RB, 1998, CIRCULATION, V98, P2513, DOI 10.1161/01.CIR.98.23.2513
   Gouni-Berthold I, 2011, CURR VASC PHARMACOL, V9, P682, DOI 10.2174/157016111797484071
   Gulcan E, 2007, MED HYPOTHESES, V69, P1313, DOI 10.1016/j.mehy.2007.03.022
   Hogue JC, 2008, METABOLISM, V57, P380, DOI 10.1016/j.metabol.2007.10.014
   Holdaas H, 2011, J AM SOC NEPHROL, V22, P1335, DOI 10.1681/ASN.2010090987
   Horwood F, 2008, DIABETES OBES METAB, V10, P181, DOI 10.1111/j.1463-1326.2007.00732.x
   Hu Y, 2009, DIABETES VASC DIS RE, V6, P262, DOI 10.1177/1479164109339966
   Jimenez JG, 2013, DIABETES OBES METAB, V15, P513, DOI 10.1111/dom.12059
   Kadoglou NPE, 2012, ACTA DIABETOL, V49, P269, DOI 10.1007/s00592-011-0310-0
   Karlson BW, 2012, NUTR METAB CARDIOVAS, V22, P697, DOI 10.1016/j.numecd.2012.03.003
   Karnib HH, 2010, DIABETES RES CLIN PR, V89, P201, DOI 10.1016/j.diabres.2010.05.022
   Katsiki N, 2011, CURR VASC PHARMACOL, V9, P698, DOI 10.2174/157016111797484152
   Katsiki N, 2011, ANGIOLOGY, V62, P601, DOI 10.1177/0003319711409201
   Katsiki N, 2011, EXPERT OPIN THER TAR, V15, P401, DOI 10.1517/14728222.2011.553609
   Keech AC, 2007, LANCET, V370, P1687, DOI 10.1016/S0140-6736(07)61607-9
   Khan HA, 2007, CLIN EXP MED, V7, P24, DOI 10.1007/s10238-007-0121-3
   Kimura Y, 2010, J GASTROENTEROL, V45, P750, DOI 10.1007/s00535-010-0203-y
   Knopp RH, 2006, DIABETES CARE, V29, P1478, DOI 10.2337/dc05-2415
   Kolovou GD, 2011, CURR VASC PHARMACOL, V9, P258
   Kolski B, 2012, CURR OPIN LIPIDOL, V23, P560, DOI 10.1097/MOL.0b013e3283598d81
   Kostapanos MS, 2012, ANGIOLOGY, V63, P569, DOI 10.1177/0003319711436077
   Koutouzis M, 2007, ATHEROSCLEROSIS, V192, P457, DOI 10.1016/j.atherosclerosis.2007.01.035
   LaRosa JC, 2005, NEW ENGL J MED, V352, P1425, DOI 10.1056/NEJMoa050461
   LaRosa JC, 2010, AM J CARDIOL, V105, P283, DOI 10.1016/j.amjcard.2009.09.025
   Liao J, 2010, CURR ATHEROSCLER REP, V12, P349, DOI 10.1007/s11883-010-0086-7
   Lioudaki E, 2011, CURR PHARM DESIGN, V17, P3632, DOI 10.2174/138161211798220945
   Macchia A, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0032894
   Madaj PM, 2012, ACAD RADIOL, V19, P889, DOI 10.1016/j.acra.2012.03.013
   März W, 2011, CLIN J AM SOC NEPHRO, V6, P1316, DOI 10.2215/CJN.09121010
   Mandosi E, 2010, J ATHEROSCLER THROMB, V17, P539, DOI 10.5551/jat.2956
   Marzilli M, 2010, AM J CARDIOVASC DRUG, V10, P3, DOI 10.2165/1153644-S0-000000000-00000
   Matikainen N, 2010, PRIM CARE DIABETES, V4, P9, DOI 10.1016/j.pcd.2010.01.005
   Migrino RQ, 2011, J CARDIOVASC MAGN R, V13, DOI 10.1186/1532-429X-13-37
   Mikhailidis DP, 2011, CURR VASC PHARMACOL, V9, P533
   Miller M, 2013, CARDIOLOGY, V125, P74, DOI 10.1159/000347134
   Monami M, 2012, ADV THER, V29, P736, DOI 10.1007/s12325-012-0045-5
   Mundil D, 2012, DIABETES VASC DIS RE, V9, P95, DOI 10.1177/1479164112441526
   Nikolic D, 2013, NUTRIENTS, V5, P928, DOI 10.3390/nu5030928
   Nozue T, 2012, CORONARY ARTERY DIS, V23, P239, DOI 10.1097/MCA.0b013e328351f919
   Nseir W, 2012, DIGEST DIS SCI, V57, P1773, DOI 10.1007/s10620-012-2118-3
   Onat A, 2011, EXPERT OPIN PHARMACO, V12, P1887, DOI 10.1517/14656566.2011.585462
   Orr JD, 2008, CURR ATHEROSCLER REP, V10, P11
   Otocka-Kmiecik A, 2012, PROG LIPID RES, V51, P314, DOI 10.1016/j.plipres.2012.03.003
   Pang J, 2012, CURR OPIN LIPIDOL, V23, P303, DOI 10.1097/MOL.0b013e328354c790
   Papanas N, 2011, ANGIOLOGY, V62, P291, DOI 10.1177/0003319710394164
   Paraskevas KI, 2007, CURR DRUG TARGETS, V8, P942
   Paraskevas KI, 2012, CURR OPIN CARDIOL, V27, P392, DOI 10.1097/HCO.0b013e328353add9
   Pehlivanidis AN, 2001, ATHEROSCLEROSIS, V157, P463, DOI 10.1016/S0021-9150(00)00746-2
   Perk J, 2012, INT J BEHAV MED, V19, P403, DOI 10.1007/s12529-012-9242-5
   Plutzky J, 2011, AM J CARDIOL, V108, p25B, DOI 10.1016/j.amjcard.2011.03.014
   Postma CT, 2012, EUR J INTERN MED, V23, P639, DOI 10.1016/j.ejim.2012.06.003
   Postula M, 2012, CARDIOL J, V19, P494, DOI 10.5603/CJ.2012.0090
   Preiss D, 2011, JAMA-J AM MED ASSOC, V305, P2556, DOI 10.1001/jama.2011.860
   Qi QB, 2012, CLIN LIPIDOL, V7, P397, DOI 10.2217/CLP.12.46
   Querton L, 2012, J CLIN LIPIDOL, V6, P434, DOI 10.1016/j.jacl.2012.04.002
   Rahangdale S, 2009, FRONT BIOSCI-LANDMRK, V14, P192, DOI 10.2741/3240
   Ridker PM, 2012, LANCET, V380, P565, DOI 10.1016/S0140-6736(12)61190-8
   Rizzo M, 2009, EXPERT OPIN INV DRUG, V18, P1495, DOI 10.1517/14728220903241633
   Rosen JB, 2013, DIABETES VASC DIS RE, V10, P277, DOI 10.1177/1479164112465212
   Ruokoniemi P, 2011, BRIT J CLIN PHARMACO, V71, P766, DOI 10.1111/j.1365-2125.2010.03895.x
   Sandhu S, 2006, J AM SOC NEPHROL, V17, P2006, DOI 10.1681/ASN.2006010012
   Santini E, 2008, J ENDOCRINOL INVEST, V31, P660, DOI 10.1007/BF03345621
   Sarigianni M, 2010, CURR MED RES OPIN, V26, P2517, DOI 10.1185/03007995.2010.518519
   Sattar N, 2013, DIABETOLOGIA, V56, P686, DOI 10.1007/s00125-012-2817-5
   Sever PS, 2005, DIABETES CARE, V28, P1151, DOI 10.2337/diacare.28.5.1151
   Sheng X, 2012, EUR J CLIN PHARMACOL, V68, P1201, DOI 10.1007/s00228-012-1234-5
   Shepherd J, 2008, J AM COLL CARDIOL, V51, P1448, DOI 10.1016/j.jacc.2007.11.072
   Shepherd J, 2006, DIABETES CARE, V29, P1220, DOI 10.2337/dc05-2465
   Soedamah-Muthu SS, 2012, BMJ OPEN, V2, DOI 10.1136/bmjopen-2012-001360
   Sur RL, 2013, CLIN NEPHROL, V79, P351, DOI 10.5414/CN107775
   Takayama T., 2013, J Cardiol
   Tandon N, 2012, AM J CARDIOVASC DRUG, V12, P7, DOI 10.2165/11594650-000000000-00000
   Targher G, 2013, J CLIN ENDOCR METAB, V98, P483, DOI 10.1210/jc.2012-3093
   Tuomilehto J, 2004, INT J CLIN PRACT, V58, P30, DOI 10.1111/j.1368-504X.2004.00390.x
   Tuomilehto J, 2003, DIABETES RES CLIN PR, V61, pS27, DOI 10.1016/S0168-8227(03)00125-6
   Udell JA, 2012, CLIN CARDIOL, V35, P722, DOI 10.1002/clc.22032
   Ukinc K, 2009, ENDOCRINE, V35, P380, DOI 10.1007/s12020-009-9157-3
   Vaverkova H, 1997, EXP CLIN ENDOCR DIAB, V105, P74, DOI 10.1055/s-0029-1211803
   Wanner C, 2005, NEW ENGL J MED, V353, P238, DOI 10.1056/NEJMoa043545
   Waters DD, 2013, J AM COLL CARDIOL, V61, P148, DOI 10.1016/j.jacc.2012.09.042
   Wierzbicki AS, 2012, CURR OPIN CARDIOL, V27, P398, DOI 10.1097/HCO.0b013e328353adc1
   Wilhelmsen L, 2001, EUR HEART J, V22, P1119, DOI 10.1053/euhj.2000.2481
   Yang XL, 2012, DIABETES-METAB RES, V28, P379, DOI 10.1002/dmrr.2287
   Younis NN, 2013, CLIN SCI, V124, P343, DOI 10.1042/CS20120304
   Zeichner S, 2012, J CANCER RES THER, V8, P176, DOI 10.4103/0973-1482.98967
   Zhang L, 2012, ATHEROSCLEROSIS, V223, P78, DOI 10.1016/j.atherosclerosis.2012.01.031
   Zoungas S, 2010, NEW ENGL J MED, V363, P1410, DOI 10.1056/NEJMoa1003795
NR 163
TC 46
Z9 47
U1 0
U2 27
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2014
VL 20
IS 22
BP 3665
EP 3674
DI 10.2174/13816128113196660673
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AK5CE
UT WOS:000338441000017
PM 24040875
DA 2025-06-11
ER

PT J
AU Royes, LFF
   Gomez-Pinilla, F
AF Freire Royes, Luiz Fernando
   Gomez-Pinilla, Fernando
TI Making sense of gut feelings in the traumatic brain injury pathogenesis
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Metabolic syndrome; TBI; Inflammation; Autonomic nervous system; Brain
   plasticity
ID GROWTH-HORMONE DEFICIENCY; BODY-MASS INDEX; MITOCHONDRIAL TRANSCRIPTION
   FACTOR; NF-KAPPA-B; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   SKELETAL-MUSCLE; METABOLIC SYNDROME; PHYSICAL-EXERCISE; FACTOR-I
AB Traumatic brain injury (TBI) is a devastating condition which often initiates a sequel of neurological disorders that can last throughout lifespan. From metabolic perspective, TBI also compromises systemic physiology including the function of body organs with subsequent malfunctions in metabolism. The emerging panorama is that the effects of TBI on the periphery strike back on the brain and exacerbate the overall TBI pathogenesis. An increasing number of clinical reports are alarming to show that metabolic dysfunction is associated with incidence of long-term neurological and psychiatric disorders. The autonomic nervous system, associated hypothalamic-pituitary axis, and the immune system are at the center of the interface between brain and body and are central to the regulation of overall homeostasis and disease. We review the strong association between mechanisms that regulate cell metabolism and inflammation which has important clinical implications for the communication between body and brain. We also discuss the integrative actions of lifestyle interventions such as diet and exercise on promoting brain and body health and cognition after TBI.
C1 [Freire Royes, Luiz Fernando] Fed Univ Santa Maria UFSM, Ctr Phys Educ & Sports, Exercise Biochem Lab, Santa Maria, RS, Brazil.
   [Gomez-Pinilla, Fernando] Univ Calif Los Angeles, UCLA Brain Injury Res Ctr, Dept Neurosurg, Los Angeles, CA USA.
   [Gomez-Pinilla, Fernando] Univ Calif Los Angeles, UCLA Brain Injury Res Ctr, Dept Integrat & Biol & Physiol, Los Angeles, CA USA.
C3 Universidade Federal de Santa Maria (UFSM); University of California
   System; University of California Los Angeles; University of California
   System; University of California Los Angeles
RP Gomez-Pinilla, F (corresponding author), Univ Calif Los Angeles, Dept Integrat Biol & Physiol, Los Angeles, CA 90095 USA.
EM fgomezpi@ucla.edu
RI royes, luiz/T-3581-2019
FU National Institute of Health [R01 NS50465]; Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico award CNPq [307382/2017-6]
FX This work was supported by The National Institute of Health award R01
   NS50465 to FGP, and Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico award CNPq: #307382/2017-6 to LFR. Author would like to
   thanks Rafael Parcianelio Cipolat for reviewing the colorartwork
   (Figures).
CR Adzovic L, 2015, J NEUROINFLAMM, V12, DOI 10.1186/s12974-015-0282-z
   Agha A, 2004, CLIN ENDOCRINOL, V60, P584, DOI 10.1111/j.1365-2265.2004.02023.x
   Agrawal D, 2016, J NEUROTRAUM, V33, P853, DOI 10.1089/neu.2015.4015
   Agrawal J, 2016, J PEDIATR ENDOCR MET, V29, P893, DOI 10.1515/jpem-2015-0335
   Agrawal R, 2016, J CEREBR BLOOD F MET, V36, P941, DOI 10.1177/0271678X15606719
   Agrawal R, 2012, J PHYSIOL-LONDON, V590, P2485, DOI 10.1113/jphysiol.2012.230078
   Aimaretti G, 2004, GROWTH HORM IGF RES, V14, pS114, DOI 10.1016/j.ghir.2004.03.025
   Aimaretti G, 2004, CLIN ENDOCRINOL, V61, P320, DOI 10.1111/j.1365-2265.2004.02094.x
   Ajmo CT, 2008, J NEUROSCI RES, V86, P2227, DOI 10.1002/jnr.21661
   Al-Sadi R, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0085345
   Alali AS, 2017, NEUROSURGERY, V80, P534, DOI 10.1093/neuros/nyw098
   Alavi SA, 2016, BRIT J NEUROSURG, V30, P302, DOI 10.3109/02688697.2015.1109060
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Silva LFA, 2013, J NEUROTRAUM, V30, P1278, DOI 10.1089/neu.2012.2577
   Alonso M, 2002, CELL MOL NEUROBIOL, V22, P663, DOI 10.1023/A:1021848706159
   Anderson GD, 2015, AAPS J, V17, P1255, DOI 10.1208/s12248-015-9792-y
   Andrews AM, 2016, FRONT CELL NEUROSCI, V10, DOI 10.3389/fncel.2016.00043
   Andruszkow H, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/345702
   Angelucci F, 2005, MOL PSYCHIATR, V10, P345, DOI 10.1038/sj.mp.4001637
   [Anonymous], 2017, INT J MOL SCI
   [Anonymous], 2017, INT J ADV MANUF TECH
   Anthony DC, 2013, MOL CELL NEUROSCI, V53, P1, DOI 10.1016/j.mcn.2012.11.005
   Anthony DC, 2012, BRAIN BEHAV IMMUN, V26, P534, DOI 10.1016/j.bbi.2011.10.011
   Aperghis M, 2004, BRAIN RES, V1009, P213, DOI 10.1016/j.brainres.2004.02.049
   Archer T, 2012, ACTA NEUROL SCAND, V125, P293, DOI 10.1111/j.1600-0404.2011.01638.x
   Asehnoune K, 2017, INTENS CARE MED, V43, P1340, DOI 10.1007/s00134-017-4895-9
   Ayton S, 2014, FREE RADICAL BIO MED, V69, P331, DOI 10.1016/j.freeradbiomed.2014.01.041
   Bansal D, 2009, PLOS NEGLECT TROP D, V3, DOI 10.1371/journal.pntd.0000551
   Bansal V, 2010, J NEUROTRAUM, V27, P2255, DOI 10.1089/neu.2010.1372
   Bansal V, 2009, J NEUROTRAUM, V26, P1353, DOI 10.1089/neu.2008-0858
   Bartke A, 2011, TRENDS ENDOCRIN MET, V22, P437, DOI 10.1016/j.tem.2011.07.004
   Bartke A, 2011, EXP GERONTOL, V46, P108, DOI 10.1016/j.exger.2010.08.020
   Bateman JM, 2006, CELL MOL LIFE SCI, V63, P1701, DOI 10.1007/s00018-006-6036-4
   Bedinger DH, 2015, MOL CELL ENDOCRINOL, V415, P143, DOI 10.1016/j.mce.2015.08.013
   Behan LA, 2008, J NEUROL NEUROSUR PS, V79, P753, DOI 10.1136/jnnp.2007.132837
   Berryman DE, 2013, NAT REV ENDOCRINOL, V9, P346, DOI 10.1038/nrendo.2013.64
   Bierhaus A, 2003, P NATL ACAD SCI USA, V100, P1920, DOI 10.1073/pnas.0438019100
   Bogdan Y, 2016, J ORTHOP TRAUMA, V30, P177, DOI 10.1097/BOT.0000000000000516
   Booth FW, 2012, COMPR PHYSIOL, V2, P1143, DOI 10.1002/cphy.c110025
   Booth FW, 2002, J APPL PHYSIOL, V93, P3, DOI 10.1152/japplphysiol.00073.2002
   Bosarge PL, 2015, J TRAUMA ACUTE CARE, V79, P289, DOI 10.1097/TA.0000000000000716
   Boulangé CL, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0303-2
   Bulger EM, 2012, J TRAUMA ACUTE CARE, V72, P567, DOI 10.1097/TA.0b013e31824baddf
   Campbell CT, 2012, BBA-GENE REGUL MECH, V1819, P921, DOI 10.1016/j.bbagrm.2012.03.002
   Campolo M, 2013, J ENDOCRINOL, V217, P291, DOI 10.1530/JOE-13-0022
   Capatina C, 2015, J CLIN MED, V4, P1448, DOI 10.3390/jcm4071448
   Romero MC, 2014, PARASITOL RES, V113, P4377, DOI 10.1007/s00436-014-4113-4
   Cazettes F, 2011, BRAIN RES, V1373, P101, DOI 10.1016/j.brainres.2010.12.008
   Chen SD, 2011, INT J MOL SCI, V12, P7199, DOI 10.3390/ijms12107199
   Chen XR, 2018, J NEUROINFLAMM, V15, DOI 10.1186/s12974-018-1345-8
   Cheng AW, 2012, NAT COMMUN, V3, DOI 10.1038/ncomms2238
   Chu WH, 2013, J TRAUMA ACUTE CARE, V74, P1446, DOI 10.1097/TA.0b013e31829246ad
   Chytrova G, 2010, BRAIN RES, V1341, P32, DOI 10.1016/j.brainres.2009.05.018
   Cisternas P, 2015, BBA-MOL BASIS DIS, V1852, P2379, DOI 10.1016/j.bbadis.2015.08.016
   Cittadini A, 2009, J CLIN ENDOCR METAB, V94, P3329, DOI 10.1210/jc.2009-0533
   Cohan P, 2005, CRIT CARE MED, V33, P2358, DOI 10.1097/01.CCM.0000181735.51183.A7
   Coste TC, 2003, DIABETES, V52, P2578, DOI 10.2337/diabetes.52.10.2578
   Cree MG, 2010, METABOLISM, V59, P703, DOI 10.1016/j.metabol.2009.09.014
   Cuisinier A, 2016, SCAND J TRAUMA RESUS, V24, DOI 10.1186/s13049-016-0323-3
   Czorlich P, 2017, WORLD NEUROSURG, V107, P515, DOI 10.1016/j.wneu.2017.08.010
   Dandona P, 2004, MED CLIN N AM, V88, P911, DOI 10.1016/j.mcna.2004.04.006
   Dandona P, 2004, TRENDS IMMUNOL, V25, P4, DOI 10.1016/j.it.2003.10.013
   Das M, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-148
   De-Souza DA, 2005, CRIT CARE MED, V33, P1125, DOI 10.1097/01.CCM.0000162680.52397.97
   Deepika A, 2018, J NEUROTRAUM, V35, P1124, DOI 10.1089/neu.2017.5151
   Desborough JP, 2000, BRIT J ANAESTH, V85, P109, DOI 10.1093/bja/85.1.109
   Di Battista AP, 2016, SHOCK, V46, P96, DOI 10.1097/SHK.0000000000000642
   Di Pietro V, 2010, J NEUROTRAUM, V27, P349, DOI 10.1089/neu.2009.1095
   Ditillo M, 2014, J TRAUMA ACUTE CARE, V76, P176, DOI 10.1097/TA.0b013e3182ab0d7c
   Eakin K, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0082016
   Ekstrand MI, 2004, HUM MOL GENET, V13, P935, DOI 10.1093/hmg/ddh109
   Farooqui AA, 2012, CELL MOL LIFE SCI, V69, P741, DOI 10.1007/s00018-011-0840-1
   Feeney C, 2017, ANN NEUROL, V82, P30, DOI 10.1002/ana.24971
   Feldman SF, 2018, PHARMACOEPIDEM DR S, V27, P797, DOI 10.1002/pds.4552
   Fenn AM, 2014, BIOL PSYCHIAT, V76, P575, DOI 10.1016/j.biopsych.2013.10.014
   Fernandez AM, 2012, NAT REV NEUROSCI, V13, P225, DOI 10.1038/nrn3209
   Fernandez-Rodriguez Eva, 2011, Front Endocrinol (Lausanne), V2, P25, DOI 10.3389/fendo.2011.00025
   Fiorin FD, 2016, J NEUROTRAUM, V33, P1317, DOI 10.1089/neu.2015.4068
   Friedrich N, 2012, DIABETES CARE, V35, P768, DOI 10.2337/dc11-1833
   Garrahy A, 2017, EUR J ENDOCRINOL, V176, pR217, DOI 10.1530/EJE-16-0962
   Geeraerts T, 2008, INTENS CARE MED, V34, P551, DOI 10.1007/s00134-007-0863-0
   Geiss LS, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0173428
   Gharib M, 2015, J TRAUMA ACUTE CARE, V78, P866, DOI 10.1097/TA.0000000000000597
   Giuliano S, 2017, ENDOCRINE, V58, P115, DOI 10.1007/s12020-016-1183-3
   Gomez-Pinilla F, 2018, PROG NEUROBIOL, V169, P76, DOI 10.1016/j.pneurobio.2018.07.001
   Gomez-Pinilla F, 2013, CURR OPIN CLIN NUTR, V16, P726, DOI 10.1097/MCO.0b013e328365aae3
   Gomez-Pinilla F, 2013, COMPR PHYSIOL, V3, P403, DOI 10.1002/cphy.c110063
   Gonzalez S, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00056
   Gralle M, 2017, J NEUROCHEM, V140, P359, DOI 10.1111/jnc.13909
   Greening DW, 2018, EXPERT REV PROTEOMIC, V15, P887, DOI 10.1080/14789450.2018.1537788
   Griesbach GS, 2011, PM&R, V3, pS64, DOI 10.1016/j.pmrj.2011.02.008
   Griesdale DEG, 2009, NEUROCRIT CARE, V11, P311, DOI 10.1007/s12028-009-9249-1
   Grundy Scott M, 2006, Clin Cornerstone, V8 Suppl 1, pS21, DOI 10.1016/S1098-3597(06)80005-0
   Hadjizacharia P, 2008, J AM COLL SURGEONS, V207, P477, DOI 10.1016/j.jamcollsurg.2008.04.017
   Hamer M, 2009, PSYCHOL MED, V39, P3, DOI 10.1017/S0033291708003681
   Hang CH, 2003, WORLD J GASTROENTERO, V9, P2776
   Hasen M, 2019, J NEUROTRAUM, V36, P1491, DOI 10.1089/neu.2018.6073
   Hashimoto M, 2002, J NEUROCHEM, V81, P1084, DOI 10.1046/j.1471-4159.2002.00905.x
   Hatton J, 2006, J NEUROSURG, V105, P843, DOI 10.3171/jns.2006.105.6.843
   Hendrick LE, 2016, AM SURGEON, V82, P575
   Hernández G, 2007, NEUROCRIT CARE, V7, P40, DOI 10.1007/s12028-007-0026-8
   Herzig S, 2001, NATURE, V413, P179, DOI 10.1038/35093131
   Hinson HE, 2017, J HEAD TRAUMA REHAB, V32, pE50, DOI 10.1097/HTR.0000000000000271
   HOFFMAN DM, 1994, LANCET, V343, P1064, DOI 10.1016/S0140-6736(94)90181-3
   Hu G, 2001, ANN HUM BIOL, V28, P412, DOI 10.1080/03014460010016671
   Hu YC, 2013, J SURG RES, V184, P1022, DOI 10.1016/j.jss.2013.04.005
   Izzo G, 2016, INT J SURG, V28, pS103, DOI 10.1016/j.ijsu.2015.05.056
   Jin P, 2014, CHIN J TRAUMATOL, V17, P125, DOI 10.3760/cma.j.issn.1008-1275.2014.03.001
   Jin W, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/502564
   Kadhim Hazim J, 2008, J Intensive Care Med, V23, P236, DOI 10.1177/0885066608318458
   Karamouzis I, 2016, ENDOCRINE, V52, P441, DOI 10.1007/s12020-015-0796-2
   Kasturi BS, 2009, J NEUROTRAUM, V26, P1315, DOI [10.1089/neu.2008.0751, 10.1089/neu.2008-0751]
   Kato T, 2007, J NEUROTRAUM, V24, P919, DOI 10.1089/neu.2006.0203
   Katzenberger RJ, 2015, FLY, V9, P68, DOI 10.1080/19336934.2015.1085623
   Kelley GL, 2004, ENDOCRINOLOGY, V145, P548, DOI 10.1210/en.2003-1167
   Kelly DF, 2006, J NEUROTRAUM, V23, P928, DOI 10.1089/neu.2006.23.928
   Keshavarzi Z, 2014, IRAN J BASIC MED SCI, V17, P406
   Kim DK, 2016, P NATL ACAD SCI USA, V113, P170, DOI 10.1073/pnas.1522297113
   Kim GS, 2012, NEUROBIOL DIS, V46, P440, DOI 10.1016/j.nbd.2012.02.008
   Kleindienst A, 2009, J NEUROTRAUM, V26, P1435, DOI 10.1089/neu.2008.0601
   Klose M, 2018, NAT REV ENDOCRINOL, V14, P57, DOI 10.1038/nrendo.2017.103
   Ko A, 2016, J TRAUMA ACUTE CARE, V80, P637, DOI 10.1097/TA.0000000000000959
   Kobata H, 2017, J NEUROTRAUM, V34, P987, DOI 10.1089/neu.2016.4662
   Krishnamoorthy V, 2017, NEUROCRIT CARE, V26, P379, DOI 10.1007/s12028-016-0335-x
   Lakshmanan R, 2010, NEUROCRIT CARE, V12, P324, DOI 10.1007/s12028-010-9342-5
   Lambillotte C, 1997, J CLIN INVEST, V99, P414, DOI 10.1172/JCI119175
   Lang YH, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0133215
   Larson BE, 2012, J SURG RES, V173, pE73, DOI 10.1016/j.jss.2011.09.056
   Lee CC, 2005, J BIOL CHEM, V280, P18543, DOI 10.1074/jbc.M414112200
   Levada OA, 2018, FRONT NEUROL, V9, DOI 10.3389/fneur.2018.00577
   Ley EJ, 2011, J TRAUMA, V70, P1141, DOI 10.1097/TA.0b013e3182146d66
   Ley RE, 2010, CURR OPIN GASTROEN, V26, P5, DOI 10.1097/MOG.0b013e328333d751
   Li M, 2018, J CLIN MED, V7, DOI 10.3390/jcm7030059
   Lim GP, 2005, J NEUROSCI, V25, P3032, DOI 10.1523/JNEUROSCI.4225-04.2005
   Lima FD, 2009, BRAIN RES, V1279, P147, DOI 10.1016/j.brainres.2009.04.052
   Lima MHM, 2002, ENDOCRINE, V18, P1, DOI 10.1385/ENDO:18:1:01
   Liu-DeRyke X, 2009, NEUROCRIT CARE, V11, P151, DOI 10.1007/s12028-009-9228-6
   Lopez-Moreno A. J., 2020, MANUAL SURVEILLANCE, P1
   Lu K, 2017, INJURY, V48, P1794, DOI 10.1016/j.injury.2017.07.004
   Lu YC, 1997, MOL CHEM NEUROPATHOL, V30, P125, DOI 10.1007/BF02815154
   Ma EL, 2017, BRAIN BEHAV IMMUN, V66, P56, DOI 10.1016/j.bbi.2017.06.018
   Majdan M, 2015, EUR J TRAUMA EMERG S, V41, P651, DOI 10.1007/s00068-014-0490-8
   Majdan M, 2016, LANCET PUBLIC HEALTH, V1, pE76, DOI 10.1016/S2468-2667(16)30017-2
   Malik VS, 2012, CURR DIABETES REP, V12, P195, DOI 10.1007/s11892-012-0259-6
   Mansoor O, 1996, P NATL ACAD SCI USA, V93, P2714, DOI 10.1073/pnas.93.7.2714
   Marques-Aleixo I, 2012, PROG NEUROBIOL, V99, P149, DOI 10.1016/j.pneurobio.2012.08.002
   Mathews EM, 2008, J AM COLL HEALTH, V57, P33, DOI 10.3200/JACH.57.1.33-38
   Mattson MP, 2008, NEURON, V60, P748, DOI 10.1016/j.neuron.2008.10.010
   Mavalli MD, 2010, J CLIN INVEST, V120, P4007, DOI 10.1172/JCI42447
   Mayer LS, 2006, INT J GERIATR PSYCH, V21, P930, DOI 10.1002/gps.1583
   McHugh GS, 2007, J NEUROTRAUM, V24, P287, DOI 10.1089/neu.2006.0031
   Mckee CA, 2016, FRONT IMMUNOL, V7, DOI 10.3389/fimmu.2016.00556
   Meng QY, 2017, EBIOMEDICINE, V16, P184, DOI 10.1016/j.ebiom.2017.01.046
   Meyfroidt G, 2017, LANCET NEUROL, V16, P721, DOI 10.1016/S1474-4422(17)30259-4
   Moinard C, 2005, INTENS CARE MED, V31, P281, DOI 10.1007/s00134-004-2489-9
   Moinard C, 2008, J NEUROTRAUM, V25, P124, DOI 10.1089/neu.2007.0391
   Molaie AM, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00176
   Mondello S, 2018, EXPERT REV PROTEOMIC, V15, P451, DOI 10.1080/14789450.2018.1464914
   Mossberg KA, 2017, J NEUROTRAUM, V34, P845, DOI 10.1089/neu.2016.4552
   Mowery NT, 2009, SURG INFECT, V10, P503, DOI 10.1089/sur.2008.086
   Mowery NT, 2009, J TRAUMA, V66, P145, DOI 10.1097/TA.0b013e3181938c5e
   Navarro A, 2009, J BIOENERG BIOMEMBR, V41, P517, DOI 10.1007/s10863-009-9250-6
   Nekludov M, 2014, J NEUROTRAUM, V31, P1927, DOI 10.1089/neu.2013.3168
   Nighot M, 2017, AM J PATHOL, V187, P2698, DOI 10.1016/j.ajpath.2017.08.005
   Nisticò R, 2012, NEUROMOL MED, V14, P262, DOI 10.1007/s12017-012-8184-z
   Ntali G, 2019, PITUITARY, V22, P283, DOI 10.1007/s11102-019-00944-0
   Nyam TTE, 2019, WORLD NEUROSURG, V122, pE740, DOI 10.1016/j.wneu.2018.10.130
   Olsen AB, 2013, NEUROGASTROENT MOTIL, V25, DOI 10.1111/nmo.12121
   Padwal RS, 2014, CAN J CARDIOL, V30, P467, DOI 10.1016/j.cjca.2013.11.004
   Park KD, 2016, BRAIN INJURY, V30, P407, DOI 10.3109/02699052.2015.1127997
   Patel NA, 2018, J NEUROINFLAMM, V15, DOI 10.1186/s12974-018-1240-3
   Patterson E, 2014, P NUTR SOC, V73, P477, DOI 10.1017/S0029665114001426
   Pieracci F, 2008, SURG INFECT, V9, P121, DOI 10.1089/sur.2007.039
   Plesnila N, 2016, CURR OPIN PHARMACOL, V26, P110, DOI 10.1016/j.coph.2015.10.008
   Pratt SI, 2016, TRANSL BEHAV MED, V6, P478, DOI 10.1007/s13142-016-0407-7
   Quinkler M, 2018, CLIN ENDOCRINOL, V89, P30, DOI 10.1111/cen.13609
   Radak Z, 2008, AGEING RES REV, V7, P34, DOI 10.1016/j.arr.2007.04.004
   Ranke MB, 2018, NAT REV ENDOCRINOL, V14, P285, DOI 10.1038/nrendo.2018.22
   Rasouli J, 2011, Einstein J Biol Med, V27, P74
   Rau CS., 2017, Int J Environ Res Public Health, V14
   Rauch S, 2012, J CRIT CARE, V27, DOI 10.1016/j.jcrc.2011.12.002
   Ray Katrina, 2012, Nat Rev Gastroenterol Hepatol, V9, P244, DOI 10.1038/nrgastro.2012.61
   Reilly SM, 2017, NAT REV ENDOCRINOL, V13, P633, DOI 10.1038/nrendo.2017.90
   Rhee SH, 2009, NAT REV GASTRO HEPAT, V6, P306, DOI 10.1038/nrgastro.2009.35
   Ritzel RM, 2018, J NEUROTRAUM, V35, P1419, DOI 10.1089/neu.2017.5399
   Rizoli SB, 2017, CRIT CARE, V21, DOI 10.1186/s13054-017-1620-6
   Roozenbeek B, 2013, NAT REV NEUROL, V9, P231, DOI 10.1038/nrneurol.2013.22
   Roquilly A, 2013, CRIT CARE, V17, DOI 10.1186/cc13138
   Rothman SM, 2013, NEUROSCIENCE, V239, P228, DOI 10.1016/j.neuroscience.2012.10.014
   Ruan H, 2002, DIABETES, V51, P3176, DOI 10.2337/diabetes.51.11.3176
   Ruegsegger GN, 2017, FRONT ENDOCRINOL, V8, DOI 10.3389/fendo.2017.00109
   Santarsieri M, 2014, J NEUROTRAUM, V31, P699, DOI 10.1089/neu.2013.3177
   Schmidt C, 2015, NATURE, V518, pS12, DOI 10.1038/518S13a
   Schneider KJ, 2017, BRIT J SPORT MED, V51, DOI 10.1136/bjsports-2016-097475
   Schober ME, 2012, J NEUROTRAUM, V29, P2075, DOI 10.1089/neu.2011.2276
   Schwulst SJ, 2013, J TRAUMA ACUTE CARE, V75, P780, DOI 10.1097/TA.0b013e318299616a
   Shahidi B, 2018, J NEUROTRAUM, V35, P398, DOI 10.1089/neu.2017.5172
   Sharma S, 2009, NEUROSCIENCE, V161, P1037, DOI 10.1016/j.neuroscience.2009.04.042
   Sherman M, 2016, J NEUROINFLAMM, V13, DOI 10.1186/s12974-016-0641-4
   Shi J, 2016, ONCOTARGET, V7, P71052, DOI 10.18632/oncotarget.11958
   Shibahashi K, 2017, J INTENSIVE CARE, V5, DOI 10.1186/s40560-016-0205-9
   Shitaka Y, 2011, J NEUROPATH EXP NEUR, V70, P551, DOI 10.1097/NEN.0b013e31821f891f
   Shlosberg D, 2010, NAT REV NEUROL, V6, P393, DOI 10.1038/nrneurol.2010.74
   Silva PPB, 2015, J NEUROTRAUM, V32, P1789, DOI 10.1089/neu.2015.3998
   Silva PE, 2018, J CRIT CARE, V44, P87, DOI 10.1016/j.jcrc.2017.10.026
   Simsek Y, 2015, CLIN ENDOCRINOL, V82, P45, DOI 10.1111/cen.12528
   Singh IN, 2006, J CEREBR BLOOD F MET, V26, P1407, DOI 10.1038/sj.jcbfm.9600297
   Stein DM, 2012, SHOCK, V37, P563, DOI 10.1097/SHK.0b013e3182534f93
   Stigger FS, 2019, J GERONTOL A-BIOL, V74, P616, DOI 10.1093/gerona/gly173
   Stoecklein VM, 2012, J LEUKOCYTE BIOL, V92, P539, DOI 10.1189/jlb.0212072
   Sullivan EM, 2018, ADV NUTR, V9, P247, DOI 10.1093/advances/nmy007
   Sun B, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0128214
   Sundman MH, 2017, BRAIN BEHAV IMMUN, V66, P31, DOI 10.1016/j.bbi.2017.05.009
   Szendroedi J, 2012, DIABETES, V61, P3176, DOI 10.2337/db12-0108
   Tan HJ, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-04008-w
   Tanriverdi F, 2015, J CLIN MED, V4, P847, DOI 10.3390/jcm4050847
   Tanriverdi F, 2015, ENDOCR REV, V36, P305, DOI 10.1210/er.2014-1065
   Taylor BC, 2017, J NEUROTRAUM, V34, P2567, DOI 10.1089/neu.2016.4910
   de Castro MRT, 2017, J PHYSIOL-LONDON, V595, P6023, DOI 10.1113/JP273933
   Tsatsoulis A, 2013, METABOLISM, V62, P622, DOI 10.1016/j.metabol.2012.11.004
   Tyagi E, 2015, NEUROBIOL DIS, V73, P307, DOI 10.1016/j.nbd.2014.09.014
   Undurti A, 2018, FRONT NEUROL, V9, DOI 10.3389/fneur.2018.00072
   Van den Berghe G, 2006, DIABETES, V55, P3151, DOI 10.2337/db06-0855
   van der Heide LP, 2006, PROG NEUROBIOL, V79, P205, DOI 10.1016/j.pneurobio.2006.06.003
   van der Poll T, 1999, INFECT DIS CLIN N AM, V13, P413, DOI 10.1016/S0891-5520(05)70083-0
   Venkata C, 2018, CLIN MED RES, V16, P57, DOI 10.3121/cmr.2018.1437
   Ventura-Clapier R, 2008, CARDIOVASC RES, V79, P208, DOI 10.1093/cvr/cvn098
   Verstrepen L, 2008, CELL MOL LIFE SCI, V65, P2964, DOI 10.1007/s00018-008-8064-8
   Vespa P, 2005, J CEREBR BLOOD F MET, V25, P763, DOI 10.1038/sj.jcbfm.9600073
   Villapol S, 2015, AM J PATHOL, V185, P2641, DOI 10.1016/j.ajpath.2015.06.016
   Villapol S, 2015, BRAIN, V138, DOI 10.1093/brain/awv172
   Vivar C, 2017, PHYSIOLOGY, V32, P410, DOI 10.1152/physiol.00017.2017
   Wagner AK, 2011, J CEREBR BLOOD F MET, V31, P1886, DOI 10.1038/jcbfm.2011.31
   Walker PA, 2012, SURGERY, V152, P790, DOI 10.1016/j.surg.2012.06.006
   Washington PM, 2016, EXP NEUROL, V275, P381, DOI 10.1016/j.expneurol.2015.06.015
   Willeumier K, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2011.67
   WOOLF CJ, 1987, NEUROSCI LETT, V73, P209, DOI 10.1016/0304-3940(87)90246-1
   Wright DK, 2017, CEREB CORTEX, V27, P4503, DOI 10.1093/cercor/bhw254
   Wu AG, 2014, NEUROREHAB NEURAL RE, V28, P75, DOI 10.1177/1545968313498650
   Xiang LS, 2014, AM J PHYSIOL-HEART C, V306, pH684, DOI 10.1152/ajpheart.00868.2013
   Yehuda H, 2011, ATHEROSCLEROSIS, V218, P339, DOI 10.1016/j.atherosclerosis.2011.07.120
   Yi Y, 2018, MOL NEUROBIOL, V55, P2454, DOI 10.1007/s12035-017-0504-8
   Zhang XC, 2005, EXP NEUROL, V191, P318, DOI 10.1016/j.expneurol.2004.10.011
   Zhang X, 2015, JPEN-PARENTER ENTER, V39, P114, DOI 10.1177/0148607113501881
   Zhang YL, 2015, J NEUROSURG, V122, P856, DOI 10.3171/2014.11.JNS14770
   Zhao Q, 2019, J NEUROTRAUM, V36, P619, DOI 10.1089/neu.2018.5766
   Zhou J, 2017, FRONT ENDOCRINOL, V8, DOI 10.3389/fendo.2017.00231
   Zhu KJ, 2014, WORLD J GASTROENTERO, V20, P9585, DOI 10.3748/wjg.v20.i28.9585
   Zlotnik A, 2012, J NEUROSURG ANESTH, V24, P30, DOI 10.1097/ANA.0b013e318232deaa
   Zygun DA, 2006, NEUROCRIT CARE, V5, P108, DOI 10.1385/NCC:5:2:108
NR 250
TC 31
Z9 34
U1 0
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD JUL
PY 2019
VL 102
BP 345
EP 361
DI 10.1016/j.neubiorev.2019.05.012
PG 17
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA IE1EF
UT WOS:000472128000025
PM 31102601
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Vogt, B
   Burnier, M
AF Vogt, Bruno
   Burnier, Michel
TI Aldosterone and cardiovascular risk
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
ID PLASMA-RENIN ACTIVITY; BLOOD-PRESSURE; METABOLIC SYNDROME; SERUM
   ALDOSTERONE; PRIMARY HYPERALDOSTERONISM; INSULIN; HYPERTENSION;
   INHIBITION; FIBROSIS; SALT
AB Through its classic effects on sodium and potassium homeostasis, aldosterone, when produced in excess, is associated with the development of hypertension and hence with higher cardiovascular and renal risk. In recent years, experimental and epidemiologic data have suggested that aldosterone also may be linked to high cardiovascular risk independently of its effects on blood pressure. Thus, aldosterone has been associated with obesity and metabolic syndrome in selected populations, and these associations may further contribute to the higher cardiovascular risk of subjects with elevated aldosterone levels. Moreover, aldosterone has been reported to promote inflammation, oxidative stress, and fibrosis in a number of tissues. Clinical evidence indicates that patients with primary hyperaldosteronism have a higher risk of developing cardiovascular and renal complications than patients with essential hypertension who have the same level of blood pressure. Aldosterone receptor blockade has been shown to lower cardiovascular mortality after myocardial infarction and in patients with congestive heart failure. Some studies have also demonstrated that aldosterone blockade could have a favorable impact on the progression of renal disease. However, prospective interventional trials are needed to further evaluate the impact of blockade of aldosterone on cardiovascular risk.
C1 [Burnier, Michel] CHU Vaudois, Serv Nephrol & Hypertens, CH-1011 Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV)
RP Burnier, M (corresponding author), CHU Vaudois, Serv Nephrol & Hypertens, Rue Bugnon 17, CH-1011 Lausanne, Switzerland.
EM michel.burnier@chuv.ch
RI Burnier, Michel/HWQ-3033-2023; Vogt, Bruno/AAS-2876-2020
OI Vogt, Bruno/0000-0002-1548-6387
CR Andronico G, 2001, INT J OBESITY, V25, P239, DOI 10.1038/sj.ijo.0801483
   Barter PJ, 2007, NEW ENGL J MED, V357, P2109, DOI 10.1056/NEJMoa0706628
   Beygui F, 2006, CIRCULATION, V114, P2604, DOI 10.1161/CIRCULATIONAHA.106.634626
   Blasi ER, 2003, KIDNEY INT, V63, P1791, DOI 10.1046/j.1523-1755.2003.00929.x
   Bochud M, 2006, HYPERTENSION, V48, P239, DOI 10.1161/01.HYP.0000231338.41548.fc
   BRILLA CG, 1993, J MOL CELL CARDIOL, V25, P563, DOI 10.1006/jmcc.1993.1066
   Burnier M, 2007, NEPHROL DIAL TRANSPL, V22, P2426, DOI 10.1093/ndt/gfm321
   Calle C, 2003, J STEROID BIOCHEM, V84, P543, DOI 10.1016/S0960-0760(03)00072-4
   Catena C, 2008, ARCH INTERN MED, V168, P80, DOI 10.1001/archinternmed.2007.33
   Connell JMC, 2005, J ENDOCRINOL, V186, P1, DOI 10.1677/joe.1.06017
   Connell JMC, 2008, ENDOCR REV, V29, P133, DOI 10.1210/er.2007-0030
   Dall'Asta C, 2009, NUTR METAB CARDIOVAS, V19, P110, DOI 10.1016/j.numecd.2008.06.001
   Davies E, 2003, CLIN EXP PHARMACOL P, V30, P437, DOI 10.1046/j.1440-1681.2003.03867.x
   Egan BM, 2005, AM J HYPERTENS, V18, P3, DOI 10.1016/j.amjhyper.2004.08.008
   EGAN BM, 1994, AM J HYPERTENS, V7, P886, DOI 10.1093/ajh/7.10.886
   Fallo F, 2006, J CLIN ENDOCR METAB, V91, P454, DOI 10.1210/jc.2005-1733
   Forrest MJ, 2008, BRIT J PHARMACOL, V154, P1465, DOI 10.1038/bjp.2008.229
   Fox CS, 2006, KIDNEY INT, V69, P2064, DOI 10.1038/sj.ki.5000378
   Giacchetti G, 2007, J HYPERTENS, V25, P177, DOI 10.1097/HJH.0b013e3280108e6f
   Gomez-Sanchez EP, 2004, ENDOCRINOLOGY, V145, P4796, DOI 10.1210/en.2004-0295
   Goodfriend TL, 2002, PROSTAG LEUKOTR ESS, V67, P163, DOI 10.1054/plef.2002.0414
   Goodfriend TL, 1998, ENDOCR RES, V24, P789, DOI 10.3109/07435809809032689
   GOODFRIEND TL, 1995, HYPERTENSION, V25, P30, DOI 10.1161/01.HYP.25.1.30
   Grim CE, 2005, HYPERTENSION, V45, P766, DOI 10.1161/01.HYP.0000154364.00763.d5
   Kathiresan S, 2005, AM J HYPERTENS, V18, P657, DOI 10.1016/j.amjhyper.2004.12.005
   Kidambi S, 2007, HYPERTENSION, V49, P704, DOI 10.1161/01.HYP.0000253258.36141.c7
   Lea WB, 2009, KIDNEY INT, V75, P936, DOI 10.1038/ki.2009.9
   Matrozova J, 2009, HYPERTENSION, V53, P605, DOI 10.1161/HYPERTENSIONAHA.108.122002
   Milliez P, 2005, J AM COLL CARDIOL, V45, P1243, DOI 10.1016/j.jacc.2005.01.015
   Pitt B, 2003, NEW ENGL J MED, V348, P1309, DOI 10.1056/NEJMoa030207
   Pitt B, 1999, NEW ENGL J MED, V341, P709, DOI 10.1056/NEJM199909023411001
   Reincke M, 2009, J CLIN ENDOCR METAB, V94, P869, DOI 10.1210/jc.2008-1851
   Rocha R, 2001, TRENDS ENDOCRIN MET, V12, P308, DOI 10.1016/S1043-2760(01)00432-5
   Rocha R, 2000, ENDOCRINOLOGY, V141, P3871, DOI 10.1210/en.141.10.3871
   Rocha R, 2002, AM J PHYSIOL-HEART C, V283, pH1802, DOI 10.1152/ajpheart.01096.2001
   Rossi GP, 2008, TRENDS ENDOCRIN MET, V19, P88, DOI 10.1016/j.tem.2008.01.006
   Rossier BC, 2002, ANNU REV PHYSIOL, V64, P877, DOI 10.1146/annurev.physiol.64.082101.143243
   Sechi LA, 2006, JAMA-J AM MED ASSOC, V295, P2638, DOI 10.1001/jama.295.22.2638
   Silvestre JS, 1998, J BIOL CHEM, V273, P4883, DOI 10.1074/jbc.273.9.4883
   Sowers JR, 2009, ANN INTERN MED, V150, P776, DOI 10.7326/0003-4819-150-11-200906020-00005
   Strauch B, 2003, PHYSIOL RES, V52, P503, DOI 10.33549/physiolres.930298
   SWEDBERG K, 1990, CIRCULATION, V82, P1730, DOI 10.1161/01.CIR.82.5.1730
   TUCK ML, 1981, NEW ENGL J MED, V304, P930, DOI 10.1056/NEJM198104163041602
   Vasan RS, 2004, NEW ENGL J MED, V351, P33, DOI 10.1056/NEJMoa033263
   Vogt B, 2007, SEMIN NEPHROL, V27, P529, DOI 10.1016/j.semnephrol.2007.07.009
   Wang Q, 2002, J AM SOC NEPHROL, V13, DOI 10.1097/01.ASN.0000017902.77985.84
   WEBER KT, 1991, CIRCULATION, V83, P1849, DOI 10.1161/01.CIR.83.6.1849
   Widimsky J, 2001, PHYSIOL RES, V50, P603
   Widimsky J Jr, 2000, PHYSIOL RES, V49, P241, DOI 10.33549/physiolres.930000.49.241
   Yamashita R, 2004, ENDOCR J, V51, P243, DOI 10.1507/endocrj.51.243
NR 50
TC 19
Z9 22
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD DEC
PY 2009
VL 11
IS 6
BP 450
EP 455
DI 10.1007/s11906-009-0076-8
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 524YX
UT WOS:000272181400010
PM 19895757
DA 2025-06-11
ER

PT J
AU Jaja-Chimedza, A
   Zhang, L
   Wolff, K
   Graf, BL
   Kuhn, P
   Moskal, K
   Carmouche, R
   Newman, S
   Salbaum, JM
   Raskin, I
AF Jaja-Chimedza, Asha
   Zhang, Li
   Wolff, Khea
   Graf, Brittany L.
   Kuhn, Peter
   Moskal, Kristin
   Carmouche, Richard
   Newman, Susan
   Salbaum, J. Michael
   Raskin, Ilya
TI A dietary isothiocyanate-enriched moringa (Moringa oleifera) seed
   extract improves glucose tolerance in a high-fat-diet mouse model and
   modulates the gut microbiome
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Moringa; Moringa seed extract; Isothiocyanate; Metabolic syndrome; Gut
   microbiota; Blood glucose
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; MICE; OBESITY;
   INFLAMMATION; EXPRESSION; LIVER; HYPERGLYCEMIA; MACROPHAGES
AB Moringa oleifera (moringa) has been traditionally used for the treatment of diabetes and in water purification. We previously showed that moringa seed extract (MSE), standardized to its primary bioactive isothiocyanate (MIC-1), modulated inflammatory and antioxidant signaling pathways in vitro. To understand the efficacy and mechanisms of action of MSE in vivo, we incorporated MSE into the diets of normal and obese C57BL/6J male mice fed a standard low-fat diet or a very high-fat diet for 12 wk, respectively. MSE supplementation resulted in reduced body weight, decreased adiposity, improved glucose tolerance, reduced inflammatory gene expression, and increased antioxidant gene expression. 16S rRNA gene sequencing and quantitative PCR of fecal/cecal samples showed major modulation of the gut microbial community and a significantly reduced bacterial load, similar to an antibiotic response. This suggests that MSE improves metabolic health by its intracellular antiinflammatory and antioxidant activities, and/or its antibiotic-like restructuring of the gut microbiota.
C1 [Jaja-Chimedza, Asha; Zhang, Li; Wolff, Khea; Graf, Brittany L.; Kuhn, Peter; Moskal, Kristin; Raskin, Ilya] Rutgers State Univ, Sch Environm & Biol Sci, Dept Plant Biol, New Brunswick, NJ 08901 USA.
   [Carmouche, Richard; Newman, Susan; Salbaum, J. Michael] Louisiana State Univ, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
   [Zhang, Li] Shandong Univ, Sch Stomatol, Dept Human Microbiome, Shandong Prov Key Lab Oral Tissue Regenerat, Jinan 250012, Shandong, Peoples R China.
C3 Rutgers University System; Rutgers University New Brunswick; Louisiana
   State University System; Louisiana State University; Pennington
   Biomedical Research Center; Shandong University
RP Jaja-Chimedza, A; Raskin, I (corresponding author), Rutgers State Univ, Sch Environm & Biol Sci, Dept Plant Biol, New Brunswick, NJ 08901 USA.
EM jaja@sebs.rutgers.edu; raskin@sebs.rutgers.edu
OI Moskal, Kristin/0000-0001-5814-5497
FU National Center For Complementary & Integrative Health; Department of
   Plant Biology in the School of Environmental and Biological Sciences
   (SEBS) of Rutgers University; Rutgers University; COBRE [NIH8
   1P30GM118430-01]; NORC [NIH 2P30DK072476];  [5T32AT004094]
FX This publication was supported by the National Center For Complementary
   & Integrative Health and the of the under Award Number and 5T32AT004094,
   which fund the Botanical Research Center of Pennington Biomedical
   Research Center and the Department of Plant Biology in the School of
   Environmental and Biological Sciences (SEBS) of Rutgers University, and
   by the at Rutgers University (AJC, BLG, PK and IR). The content is
   solely the responsibility of the authors and does not necessarily
   represent the official views of the. This project/work used genomics
   core facilities that are supported in part by COBRE (NIH8
   1P30GM118430-01) and NORC (NIH 2P30DK072476) center grants from the.
CR Ajibola M, 2014, BASIC SCI MED, V3, P37, DOI DOI 10.5923/J.MEDICINE.20140303.01
   Al-Malki AL, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/381040
   Amaglo NK, 2010, FOOD CHEM, V122, P1047, DOI 10.1016/j.foodchem.2010.03.073
   [Anonymous], 2015, Vegan: Community Ecology Package. R Package Version 2.21, 2
   Anwar F, 2007, PHYTOTHER RES, V21, P17, DOI 10.1002/ptr.2023
   Baker GC, 2003, J MICROBIOL METH, V55, P541, DOI 10.1016/j.mimet.2003.08.009
   BENJAMINI Y, 1995, J R STAT SOC B, V57, P289, DOI 10.1111/j.2517-6161.1995.tb02031.x
   Brunelli D, 2010, BIOCHEM PHARMACOL, V79, P1141, DOI 10.1016/j.bcp.2009.12.008
   Cani PD, 2008, PATHOL BIOL, V56, P305, DOI 10.1016/j.patbio.2007.09.008
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Cani PD, 2012, GUT MICROBES, V3, P279, DOI 10.4161/gmic.19625
   Cani PD, 2011, PHARMACOL THERAPEUT, V130, P202, DOI 10.1016/j.pharmthera.2011.01.012
   Caporaso JG, 2010, NAT METHODS, V7, P335, DOI 10.1038/nmeth.f.303
   Carrier A, 2017, ANTIOXID REDOX SIGN, V26, P429, DOI 10.1089/ars.2016.6929
   Carvalho BM, 2012, DIABETOLOGIA, V55, P2823, DOI 10.1007/s00125-012-2648-4
   Cequier-Sánchez E, 2008, J AGR FOOD CHEM, V56, P4297, DOI 10.1021/jf073471e
   Chartoumpekis DV, 2013, CURR DIABETES REV, V9, P137, DOI 10.2174/1573399811309020005
   Cheenpracha S, 2010, BIOORGAN MED CHEM, V18, P6598, DOI 10.1016/j.bmc.2010.03.057
   Das Arghya, 2011, Endocrine Metabolic & Immune Disorders-Drug Targets, V11, P23
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   Ding SL, 2011, CURR OPIN CLIN NUTR, V14, P328, DOI 10.1097/MCO.0b013e3283478727
   Dinikova-Kostova AT, 2004, METHOD ENZYMOL, V382, P423
   Edgar RC, 2013, NAT METHODS, V10, P996, DOI [10.1038/NMETH.2604, 10.1038/nmeth.2604]
   EILERT U, 1981, PLANTA MED, V42, P55, DOI 10.1055/s-2007-971546
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   Fujimoto M, 2005, DIABETES, V54, P1340, DOI 10.2337/diabetes.54.5.1340
   Galuppo M, 2013, MOLECULES, V18, P14340, DOI 10.3390/molecules181114340
   Hu R, 2006, CANCER LETT, V243, P170, DOI 10.1016/j.canlet.2005.11.050
   Jaja-Chimedza A, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0182658
   Jeon SR, 2014, J GEN APPL MICROBIOL, V60, P251, DOI 10.2323/jgam.60.251
   Kozich JJ, 2013, APPL ENVIRON MICROB, V79, P5112, DOI 10.1128/AEM.01043-13
   Lawrence T, 2009, CSH PERSPECT BIOL, V1, DOI 10.1101/cshperspect.a001651
   Leone A, 2015, INT J MOL SCI, V16, P12791, DOI 10.3390/ijms160612791
   Lozupone C, 2005, APPL ENVIRON MICROB, V71, P8228, DOI 10.1128/AEM.71.12.8228-8235.2005
   Mbikay M, 2012, FRONT PHARMACOL, V3, DOI 10.3389/fphar.2012.00024
   Membrez M, 2008, FASEB J, V22, P2416, DOI 10.1096/fj.07-102723
   Munday R, 2010, J MED CHEM, V53, P4761, DOI 10.1021/jm100425v
   Olefsky JM, 2010, ANNU REV PHYSIOL, V72, P219, DOI 10.1146/annurev-physiol-021909-135846
   Omodanisi EI, 2017, MOLECULES, V22, DOI 10.3390/molecules22040439
   Padla EP, 2012, Z NATURFORSCH C, V67, P557, DOI 10.5560/ZNC.2012.67c0557
   Prawan A, 2008, PHARM RES-DORDR, V25, P836, DOI 10.1007/s11095-007-9370-9
   Rajan TS, 2016, FITOTERAPIA, V112, P104, DOI 10.1016/j.fitote.2016.05.008
   Schloss PD, 2009, APPL ENVIRON MICROB, V75, P7537, DOI 10.1128/AEM.01541-09
   Schmittgen TD, 2008, NAT PROTOC, V3, P1101, DOI 10.1038/nprot.2008.73
   Shinozaki S, 2011, J BIOL CHEM, V286, P34959, DOI 10.1074/jbc.M110.187666
   Singh S, 2010, FREE RADICAL RES, V44, P1267, DOI 10.3109/10715762.2010.507670
   THOMPSON GR, 1971, GUT, V12, P230, DOI 10.1136/gut.12.3.230
   Traka M, 2009, PHYTOCHEM REV, V8, P269, DOI 10.1007/s11101-008-9103-7
   Tumer TB, 2015, J AGR FOOD CHEM, V63, P1505, DOI 10.1021/jf505014n
   Tuorkey MJ, 2016, INTERV MED APPL SCI, V8, DOI 10.1556/1646.8.2016.3.7
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Wang Q, 2007, APPL ENVIRON MICROB, V73, P5261, DOI 10.1128/AEM.00062-07
   Wang YF, 2009, PLOS ONE, V4, DOI [10.1371/journal.pone.0005368, 10.1371/journal.pone.0007401]
   Wardyn JD, 2015, BIOCHEM SOC T, V43, P621, DOI 10.1042/BST20150014
   Waterman C, 2015, MOL NUTR FOOD RES, V59, P1013, DOI 10.1002/mnfr.201400679
   Waterman C, 2014, PHYTOCHEMISTRY, V103, P114, DOI 10.1016/j.phytochem.2014.03.028
   Wilson PWF, 2005, CIRCULATION, V112, P3066, DOI 10.1161/CIRCULATIONAHA.105.539528
   Zhang L, 2017, ISME J, V11, P676, DOI 10.1038/ismej.2016.151
   Zhao LP, 2013, NAT REV MICROBIOL, V11, P639, DOI 10.1038/nrmicro3089
NR 60
TC 59
Z9 63
U1 0
U2 56
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD AUG
PY 2018
VL 47
BP 376
EP 385
DI 10.1016/j.jff.2018.05.056
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA GN4RH
UT WOS:000439019200041
PM 30930963
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Chin, B
   Murphy, MLM
   Cohen, S
AF Chin, Brian
   Murphy, Michael L. M.
   Cohen, Sheldon
TI Age moderates the association between social integration and diurnal
   cortisol measures
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Salivary cortisol; Social integration; Age; Diurnal slopes
ID SALIVARY CORTISOL; METABOLIC SYNDROME; HEART-DISEASE; HEALTH; MORTALITY;
   SUSCEPTIBILITY; SUPPORT; SLOPES; ADULTS; RELIABILITY
AB Social integration is defined as the degree to which an individual participates in a broad range of social relationships. Although measures of social integration vary across studies, it is often assessed as the number of social roles (e.g., parent, friend, student, volunteer) that an individual reports actively participating in. More socially integrated individuals tend to be healthier than those less socially integrated, but the biological mechanisms through which this occurs remain unclear. One possibility is that social integration might alter the function of the hypothalamic-pituitary-adrenal axis, of which cortisol is a key product, and in turn influence a broad range of health outcomes. This study examined the association between social integration and two indices of cortisol in a community sample of 680 healthy men and women aged 18-55. Because the social roles held by younger individuals may be more numerous yet superficial than those held by older individuals, this study also tested the hypothesis that these associations could be moderated by age such that lower levels of integration would be associated with cortisol dysregulation for older but not younger individuals in our sample. Participants provided salivary cortisol samples during waking hours on three days that were used to calculate diurnal cortisol levels and slopes. Increased social integration was associated with lower cortisol AUC among older (ages 35-55) but not younger (ages 18-34) individuals in our sample. Moreover, while increased social integration was associated with steeper diurnal cortisol slopes regardless of age, this association was strongest among older individuals. Differences in health behaviors, affect, and psychological stress did not mediate these associations. The results of this study support cortisol as a candidate biological mechanism through which increased social integration is associated with better physical health among older individuals.
C1 [Chin, Brian; Murphy, Michael L. M.; Cohen, Sheldon] Carnegie Mellon Univ, Dept Psychol, 5000 Forbes Ave, Pittsburgh, PA 15213 USA.
C3 Carnegie Mellon University
RP Cohen, S (corresponding author), Carnegie Mellon Univ, Dept Psychol, 5000 Forbes Ave, Pittsburgh, PA 15213 USA.
EM scohen@cmu.edu
RI Chin, Brian/GPS-4971-2022
OI Chin, Brian/0000-0003-4643-0172; Murphy, Michael/0000-0001-7776-3186
FU National Center for Complementary and Integrative Health [AT006694];
   National Institute of Mental Health [MH50429]; National Heart, Lung, and
   Blood Institute [HL65111, HL65112HL65111]; National Institute for
   Allergy and Infectious Diseases [R01 AI066367]; National Institutes of
   Health [NCRR/GCRC 5M01 RR00056, UL1 RR024153, UL1 RT000005]; John D. and
   Catherine T. MacArthur Foundation Research Network on Socioeconomic
   Status Health
FX Preparation of this paper was supported by a grant from the National
   Center for Complementary and Integrative Health (AT006694); the conduct
   of the studies was supported by grants from the National Institute of
   Mental Health (MH50429), National Heart, Lung, and Blood Institute
   (HL65111; HL65112HL65111), and National Institute for Allergy and
   Infectious Diseases (R01 AI066367); and secondary support was provided
   by a grant from the National Institutes of Health to the University of
   Pittsburgh Medical Center General Clinical Research Center (NCRR/GCRC
   5M01 RR00056) and from the National Institutes of Health to the
   University of Pittsburgh Clinical and Translational Science Institute
   (UL1 RR024153 and UL1 RT000005); and supplemental support was provided
   by John D. and Catherine T. MacArthur Foundation Research Network on
   Socioeconomic Status & Health. We thank David Creswell and Brooke Feeney
   for their feedback on an earlier version of this manuscript.
CR Adam EK, 2017, PSYCHONEUROENDOCRINO, V83, P25, DOI 10.1016/j.psyneuen.2017.05.018
   Anagnostis P, 2009, J CLIN ENDOCR METAB, V94, P2692, DOI 10.1210/jc.2009-0370
   [Anonymous], SUPPORT MEASUREMENTS
   Badrick E, 2008, J CLIN ENDOCR METAB, V93, P750, DOI 10.1210/jc.2007-0737
   Badrick E, 2007, J CLIN ENDOCR METAB, V92, P819, DOI 10.1210/jc.2006-2155
   Barefoot JC, 2005, AM J EPIDEMIOL, V161, P960, DOI 10.1093/aje/kwi128
   Berkman L.F., 1983, HLTH WAYS LIVING ALA
   Berkman L.F., 2000, Social Epidemiology, DOI [DOI 10.1016/S0277-9536(00)00065-4, DOI 10.1093/OSO/9780195083316.003.0007]
   Berkman LF, 2004, AM J EPIDEMIOL, V159, P167, DOI 10.1093/aje/kwh020
   Berkman LF, 2000, SOC SCI MED, V51, P843, DOI 10.1016/S0277-9536(00)00065-4
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   CARSTENSEN LL, 1992, PSYCHOL AGING, V7, P331, DOI 10.1037/0882-7974.7.3.331
   Champaneri S, 2013, OBESITY, V21, pE56, DOI 10.1002/oby.20047
   Chang SC, 2017, CIRC RES, V120, P1927, DOI 10.1161/CIRCRESAHA.116.309443
   Cheng ST, 2014, HEALTH PSYCHOL, V33, P524, DOI 10.1037/hea0000026
   Chin B, 2017, PSYCHONEUROENDOCRINO, V78, P68, DOI 10.1016/j.psyneuen.2017.01.016
   Cohen J., 2003, ROUTLEDGE, V3rd ed., DOI [DOI 10.4324/9780203774441, 10.4324/9780203774441]
   Cohen S, 2006, PSYCHOSOM MED, V68, P41, DOI 10.1097/01.psy.0000195967.51768.ea
   Cohen S, 2003, PSYCHOSOM MED, V65, P652, DOI 10.1097/01.PSY.0000077508.57784.DA
   COHEN S, 1988, HEALTH PSYCHOL, V7, P269, DOI 10.1037/0278-6133.7.3.269
   Cohen S, 1997, JAMA-J AM MED ASSOC, V277, P1940
   COHEN S, 1988, CLAR SYMP, P31
   Cohen S., 1995, Measuring Stress: A Guide for Health and Social Scientists, DOI DOI 10.1093/OSO/9780195086416.003.0001
   Cohen S, 2007, HEALTH PSYCHOL, V26, P410, DOI 10.1037/0278-6133.26.4.410
   Dekker MJHJ, 2008, J CLIN ENDOCR METAB, V93, P3741, DOI 10.1210/jc.2008-0496
   DRESSENDORFER RA, 1992, J STEROID BIOCHEM, V43, P683, DOI 10.1016/0960-0760(92)90294-S
   Enders CK, 2007, PSYCHOL METHODS, V12, P121, DOI 10.1037/1082-989X.12.2.121
   Gaffey AE, 2016, NEUROSCI BIOBEHAV R, V68, P928, DOI 10.1016/j.neubiorev.2016.05.036
   Grant N, 2009, ANN BEHAV MED, V37, P29, DOI 10.1007/s12160-009-9081-z
   Hayes A. F., 2017, INTRO MEDIATION MODE
   Holt-Lunstad J, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000316
   HOUSE JS, 1988, SCIENCE, V241, P540, DOI 10.1037/0003-066X.59.8.676
   Hox J., 2010, MULTILEVEL ANAL TECH, DOI [DOI 10.4324/9780203852279, 10.4324/9780203852279]
   Janicki-Deverts D, 2016, BRAIN BEHAV IMMUN, V53, P255, DOI 10.1016/j.bbi.2016.01.013
   Kraemer HC, 2006, AM J GERIAT PSYCHIAT, V14, P325, DOI 10.1097/01.JGP.0000201816.26786.5b
   Kroenke CH, 2012, BREAST CANCER RES TR, V133, P375, DOI 10.1007/s10549-012-1962-3
   Pinquart M, 2010, CRIT REV ONCOL HEMAT, V75, P122, DOI 10.1016/j.critrevonc.2009.06.003
   Polk DE, 2005, PSYCHONEUROENDOCRINO, V30, P261, DOI 10.1016/j.psyneuen.2004.08.004
   Pruessner JC, 2003, PSYCHONEUROENDOCRINO, V28, P916, DOI 10.1016/S0306-4530(02)00108-7
   Raudenbush S.W., 2002, Advanced Quantitative Techniques in the Social Sciences Series, V1
   REIS HT, 1991, ADV EXP SOC PSYCHOL, V24, P269
   Sapolsky RM, 2000, ENDOCR REV, V21, P55, DOI 10.1210/er.21.1.55
   Saxbe D.E., 2008, Health Psychology Review, V2, P163, DOI [10.1080/17437190802530812, DOI 10.1080/17437190802530812]
   Seeman TE, 2002, PSYCHOSOM MED, V64, P395, DOI 10.1097/00006842-200205000-00004
   Seeman TE, 1996, ANN EPIDEMIOL, V6, P442, DOI 10.1016/S1047-2797(96)00095-6
   Segerstrom Suzanne C, 2014, Psychoneuroendocrinology, V49, P299, DOI 10.1016/j.psyneuen.2014.07.022
   Shankar A, 2011, HEALTH PSYCHOL, V30, P377, DOI 10.1037/a0022826
   Shor E, 2015, SOC SCI MED, V128, P76, DOI 10.1016/j.socscimed.2015.01.010
   UMBERSON D, 1987, J HEALTH SOC BEHAV, V28, P306, DOI 10.2307/2136848
   USALA PD, 1989, RES AGING, V11, P403, DOI 10.1177/0164027589114001
   VanCauter E, 1996, J CLIN ENDOCR METAB, V81, P2468, DOI 10.1210/jc.81.7.2468
   Yang YC, 2016, P NATL ACAD SCI USA, V113, P578, DOI 10.1073/pnas.1511085112
NR 52
TC 12
Z9 13
U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD APR
PY 2018
VL 90
BP 102
EP 109
DI 10.1016/j.psyneuen.2018.02.008
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA GD8LV
UT WOS:000430764800013
PM 29477953
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Spann, SJ
   Gillespie, CF
   Davis, JS
   Brown, A
   Schwartz, A
   Wingo, A
   Habib, L
   Ressler, KJ
AF Spann, Sarah J.
   Gillespie, Charles F.
   Davis, Jennifer S.
   Brown, Angelo
   Schwartz, Ann
   Wingo, Aliza
   Habib, Leah
   Ressler, Kerry J.
TI The association between childhood trauma and lipid levels in an adult
   low-income, minority population
SO GENERAL HOSPITAL PSYCHIATRY
LA English
DT Article
DE Trauma; African-American; Genetic; Cardiovascular; Lipids
ID POSTTRAUMATIC-STRESS-DISORDER; ADMINISTERED PTSD SCALE; METABOLIC
   SYNDROME; SUBSTANCE-ABUSE; HPA AXIS; HEALTH; DEPRESSION; VETERANS;
   EXPOSURE; DISPARITIES
AB Background: The objective of this study is to investigate the association between childhood trauma and lipid profiles in adults from a highly traumatized population at-risk for cardiovascular disease.
   Method: We recruited 452 participants, primarily African-American and of low socioeconomic status, from general medical clinics in a large urban hospital. We performed direct comparisons, univariate analysis of variance and regression analyses together and separated by sex, examining the associations of child abuse, body mass index, lipid lowering drug use, blood pressure, age, and substance use to HDL levels and HDL/LDL ratios.
   Results: A history of moderate to severe levels of childhood trauma and abuse was associated with a significant decrease in HDL levels (P <=.01) and HDL/LDL ratios (P <=.001) relative to males with low levels of abuse. This relationship held when the status of lipid-lowering drugs was considered. When controlling for age, substance abuse, tobacco use, and adult trauma, the effects of childhood trauma remained significant. We found a significant child abuse by sex interaction on HDL/LDL ratios [F(1,369)=13.0, P <=.0005] consistent with a differential effect of trauma on dyslipidemia in male but not female subjects.
   Conclusions: Our data suggest that childhood trauma exposure, obtained with self-report measures, may contribute to increased risk of cardiovascular disease by way of stress-mediated alterations of lipid concentration and composition in male, but not female, subjects. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Spann, Sarah J.; Gillespie, Charles F.; Davis, Jennifer S.; Brown, Angelo; Schwartz, Ann; Wingo, Aliza; Habib, Leah; Ressler, Kerry J.] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30329 USA.
   [Wingo, Aliza] Atlanta VA Med Ctr, Atlanta, GA USA.
   [Ressler, Kerry J.] Howard Hughes Med Inst, Chevy Chase, MD USA.
   [Ressler, Kerry J.] Yerkes Natl Primate Res Ctr, Atlanta, GA USA.
C3 Emory University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Atlanta VA Health Care System; Atlanta VA Medical
   Center; Howard Hughes Medical Institute
RP Ressler, KJ (corresponding author), Emory Univ, Howard Hughes Med Inst, Dept Psychiat & Behav Sci, Yerkes Res Ctr, 954 Gatewood Dr, Atlanta, GA 30329 USA.
EM kressle@emory.edu
RI Gillespie, Charles/G-8481-2012; Schwartz, Ann/JOZ-9672-2023; Ressler,
   Kerry/N-8741-2018
OI Ressler, Kerry/0000-0002-5158-1103; Gillespie,
   Charles/0000-0001-5476-5920
FU APIRE/Wyeth; NARSAD; NIDA; NIMH; Burroughs Wellcome Foundation
FX There were no commercial sponsors or commercial relationships related to
   the current work. All additional financial ties of the investigators
   within the last 3 years are disclosed herein: Dr. Gillespie has received
   funding from APIRE/Wyeth, NARSAD, NIDA, and NIMH. Dr. Ressler has
   received awards and/or funding support related to other studies from
   Burroughs Wellcome Foundation, NARSAD, NIMH and NIDA and is a cofounder
   of Extinction Pharmaceuticals for use of NMDA-based therapeutics with
   Psychotherapy.
CR Alim TN, 2006, J NATL MED ASSOC, V98, P1630
   [Anonymous], 1998, Manual for the Childhood Trauma Questionnaire
   Bernstein DP, 2003, CHILD ABUSE NEGLECT, V27, P169, DOI 10.1016/S0145-2134(02)00541-0
   Bernstein DP, 1997, J AM ACAD CHILD PSY, V36, P340, DOI 10.1097/00004583-199703000-00012
   BERNSTEIN DP, 1994, AM J PSYCHIAT, V151, P1132, DOI 10.1176/ajp.151.8.1132
   Binder EB, 2008, JAMA-J AM MED ASSOC, V299, P1291, DOI 10.1001/jama.299.11.1291
   Blake D.D., 1990, The Behavior Therapist, V18, P187, DOI [10.1037/t00072-000, DOI 10.1007/BF02105408]
   BLAKE DD, 1995, J TRAUMA STRESS, V8, P75, DOI 10.1007/BF02105408
   Boscarino JA, 2006, ANN EPIDEMIOL, V16, P248, DOI 10.1016/j.annepidem.2005.03.009
   Boscarino JA, 2004, ANN NY ACAD SCI, V1032, P141, DOI 10.1196/annals.1314.011
   Bradley RG, 2008, ARCH GEN PSYCHIAT, V65, P190, DOI 10.1001/archgenpsychiatry.2007.26
   Breslau N, 2004, J URBAN HEALTH, V81, P530, DOI 10.1093/jurban/jth138
   Carrion VG, 2002, BIOL PSYCHIAT, V51, P575, DOI 10.1016/S0006-3223(01)01310-5
   Chan PS, 2009, JAMA-J AM MED ASSOC, V302, P1195, DOI 10.1001/jama.2009.1340
   Clark L T, 2001, Heart Dis, V3, P97
   Coffey SF, 1998, J TRAUMA STRESS, V11, P393, DOI 10.1023/A:1024467507565
   Cook NR, 2009, CLIN CHEM, V55, P1603, DOI 10.1373/clinchem.2009.131185
   Cusack KJ, 2004, PSYCHIAT SERV, V55, P157, DOI 10.1176/appi.ps.55.2.157
   Duprez DA, 2009, ETHNIC DIS, V19, P243
   Felitti VJ, 1998, AM J PREV MED, V14, P245, DOI 10.1016/S0749-3797(98)00017-8
   First M.B., 2016, User's Guide for the SCID-5-CV Structured Clinical Interview for DSM-5 Disorders: Clinical Version
   Foa EB, 2000, J TRAUMA STRESS, V13, P181, DOI 10.1023/A:1007781909213
   Gillespie CF, 2009, GEN HOSP PSYCHIAT, V31, P505, DOI 10.1016/j.genhosppsych.2009.05.003
   Gunnar MR, 2002, PSYCHONEUROENDOCRINO, V27, P199, DOI 10.1016/S0306-4530(01)00045-2
   Gunstad J, 2006, PSYCHIAT RES, V142, P31, DOI 10.1016/j.psychres.2005.11.007
   Gustafson T B, 2004, Obes Rev, V5, P129, DOI 10.1111/j.1467-789X.2004.00145.x
   Hemmingsson T, 2005, INT J EPIDEMIOL, V34, P260, DOI 10.1093/ije/dyh314
   Jakovjevic M, 2007, PSYCHIAT DANUB, V19, P76
   Jakovljevic M, 2008, PSYCHIAT DANUB, V20, P406
   Jakovljevic Miro, 2006, Psychiatr Danub, V18, P169
   Jin H, 2009, J CLIN PSYCHOPHARM, V29, P210, DOI 10.1097/JCP.0b013e3181a45ed0
   Kellogg SH, 2003, DRUG ALCOHOL DEPEN, V69, P137, DOI 10.1016/S0376-8716(02)00308-3
   Krause N, 2004, PSYCHOL AGING, V19, P637, DOI 10.1037/0882-7974.19.4.637
   Lasa L, 2000, J AFFECT DISORDERS, V57, P261, DOI 10.1016/S0165-0327(99)00088-9
   Link CL, 2009, ETHNIC DIS, V19, P288
   Maia DB, 2008, J AFFECT DISORDERS, V107, P259, DOI 10.1016/j.jad.2007.08.013
   Martin T., 2004, ASSESSING PSYCHOL TR, P63
   Mensah GA, 2005, CIRCULATION, V111, P1233, DOI 10.1161/01.CIR.0000158136.76824.04
   Sanchez MM, 2006, HORM BEHAV, V50, P623, DOI 10.1016/j.yhbeh.2006.06.012
   Schnurr P P, 1999, Semin Clin Neuropsychiatry, V4, P295
   Schwartz AC, 2005, PSYCHIAT SERV, V56, P212, DOI 10.1176/appi.ps.56.2.212
   Shonkoff JP, 2009, JAMA-J AM MED ASSOC, V301, P2252, DOI 10.1001/jama.2009.754
   Solter V, 2002, CROAT MED J, V43, P685
   Storch EA, 2004, DEPRESS ANXIETY, V19, P187, DOI 10.1002/da.20002
   Tarullo AR, 2006, HORM BEHAV, V50, P632, DOI 10.1016/j.yhbeh.2006.06.010
   Thomas C, 2008, PEDIATRICS, V121, pE1240, DOI 10.1542/peds.2007-2403
   Trief PM, 2006, J BEHAV MED, V29, P411, DOI 10.1007/s10865-006-9067-2
   Vieweg W Victor R, 2006, Prim Care Companion J Clin Psychiatry, V8, P25
   Weathers FW, 2001, DEPRESS ANXIETY, V13, P132, DOI 10.1002/da.1029
   Williamson DF, 2002, INT J OBESITY, V26, P1075, DOI 10.1038/sj.ijo.0802038
   Zielinski DS, 2009, CHILD ABUSE NEGLECT, V33, P666, DOI 10.1016/j.chiabu.2009.09.001
NR 51
TC 22
Z9 25
U1 1
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0163-8343
EI 1873-7714
J9 GEN HOSP PSYCHIAT
JI Gen. Hosp. Psych.
PD MAR-APR
PY 2014
VL 36
IS 2
BP 150
EP 155
DI 10.1016/j.genhosppsych.2013.10.004
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AC4XZ
UT WOS:000332525900004
PM 24315076
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Allen, MS
AF Allen, Mark S.
TI Physical activity as an adjunct treatment for erectile dysfunction
SO NATURE REVIEWS UROLOGY
LA English
DT Review
ID IMPROVES ENDOTHELIAL FUNCTION; NITRIC-OXIDE; SEXUAL DYSFUNCTION;
   BODY-IMAGE; METABOLIC SYNDROME; PSYCHOLOGICAL INTERVENTIONS;
   CARDIOVASCULAR-DISEASE; DEPRESSIVE SYMPTOMS; INTERNATIONAL INDEX;
   EXERCISE INTENSITY
AB Increasing data are available to suggest that physical activity and lifestyle modification in general can benefit erectile function, with effect sizes comparable with established treatment options such as testosterone therapy and phosphodiesterase type 5 inhibitors. Despite this evidence, primary-care physicians are rarely afforded critical information on the underlying mechanisms through which physical activity works as a treatment, severely hampering treatment credibility for both physician and patient. Physical activity is associated with psychological and metabolic adaptations that are compatible with the adaptations required for the treatment of erectile dysfunction (ED). These adaptations include increased expression and activity of nitric oxide synthase, strengthened endothelial function, acute rises in testosterone, decreased stress and anxiety, and improved body image. Use of physical activity as a first-line treatment option for ED is limited, and explicit physical activity guidelines for the treatment of ED are required. Such guidelines should include not only a suggested exercise programme but also guidelines for physician-patient communication that might enhance patient receptivity and therapy continuation. An understanding of how physical activity affects erectile function, as well as its effectiveness in treating ED compared with other established treatments, can benefit urologists and primary-care physicians searching for noninvasive treatment options for men presenting with poor erectile function.
C1 [Allen, Mark S.] Univ Wollongong, Fac Social Sci, Wollongong, NSW, Australia.
C3 University of Wollongong
RP Allen, MS (corresponding author), Univ Wollongong, Fac Social Sci, Wollongong, NSW, Australia.
EM mark_allen@uow.edu.au
OI Allen, Mark/0000-0001-5511-9680
CR Abe T, 2003, BRIT J SPORT MED, V37, P543, DOI 10.1136/bjsm.37.6.543
   Ahtiainen JP, 2015, EXP GERONTOL, V69, P148, DOI 10.1016/j.exger.2015.06.010
   Akita Y, 2007, AM J PHYSIOL-HEART C, V292, pH2051, DOI 10.1152/ajpheart.01102.2006
   Alderman BL, 2007, PSYCHOPHYSIOLOGY, V44, P759, DOI 10.1111/j.1469-8986.2007.00548.x
   Allen MS, 2019, J SEX MED, V16, P531, DOI 10.1016/j.jsxm.2019.01.314
   Allen MS, 2019, J AFFECT DISORDERS, V242, P5, DOI 10.1016/j.jad.2018.08.081
   Allen MS, 2018, J SEX MED, V15, P458, DOI 10.1016/j.jsxm.2018.02.008
   Allen MS, 2014, CURR DIR PSYCHOL SCI, V23, P460, DOI 10.1177/0963721414550705
   Allen MS, 2014, CURR DIR PSYCHOL SCI, V23, P48, DOI 10.1177/0963721413513267
   Anderson TJ, 1999, J AM COLL CARDIOL, V34, P631, DOI 10.1016/S0735-1097(99)00259-4
   Andersson KE, 2011, PHARMACOL REV, V63, P811, DOI 10.1124/pr.111.004515
   ANDERSSON KE, 1995, PHYSIOL REV, V75, P191, DOI 10.1152/physrev.1995.75.1.191
   Picorelli AMA, 2014, J PHYSIOTHER, V60, P151, DOI 10.1016/j.jphys.2014.06.012
   Bala A, 2018, SEX MED REV, V6, P29, DOI 10.1016/j.sxmr.2017.07.002
   BARLOW DH, 1986, J CONSULT CLIN PSYCH, V54, P140, DOI 10.1037/0022-006X.54.2.140
   Bauman A, 2016, GERONTOLOGIST, V56, pS268, DOI 10.1093/geront/gnw031
   Bauman AE, 2012, LANCET, V380, P258, DOI 10.1016/S0140-6736(12)60735-1
   Begot I, 2015, AM J CARDIOL, V115, P571, DOI 10.1016/j.amjcard.2014.12.007
   Besiroglu H, 2015, J SEX MED, V12, P1309, DOI 10.1111/jsm.12885
   Bhasin S, 1996, NEW ENGL J MED, V335, P1, DOI 10.1056/NEJM199607043350101
   Black PH, 2003, BRAIN BEHAV IMMUN, V17, P350, DOI 10.1016/S0889-1591(03)00048-5
   Blashill AJ, 2016, ARCH SEX BEHAV, V45, P1241, DOI 10.1007/s10508-015-0683-1
   Blondell SJ, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-510
   Brotman DJ, 2007, LANCET, V370, P1089, DOI 10.1016/S0140-6736(07)61305-1
   Brumby S, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-1018
   BURNETT AL, 1992, SCIENCE, V257, P401, DOI 10.1126/science.1378650
   Burnett AL, 2018, J UROLOGY, V200, P633, DOI 10.1016/j.juro.2018.05.004
   Calvert JW, 2013, PHYSIOLOGY, V28, P216, DOI 10.1152/physiol.00011.2013
   Campbell A, 2009, J HEALTH PSYCHOL, V14, P780, DOI 10.1177/1359105309338977
   Carré JM, 2009, AM J HUM BIOL, V21, P392, DOI 10.1002/ajhb.20867
   Carter Patrice, 2010, BMJ, V341, pc4229, DOI 10.1136/bmj.c4229
   Chaouloff F, 1997, MED SCI SPORT EXER, V29, P58, DOI 10.1097/00005768-199701000-00009
   Chekroud SR, 2018, LANCET PSYCHIAT, V5, P739, DOI 10.1016/S2215-0366(18)30227-X
   Chen L, 2015, EUR UROL, V68, P674, DOI 10.1016/j.eururo.2015.03.031
   Cheng JYW, 2007, INT J IMPOT RES, V19, P229, DOI 10.1038/sj.ijir.3901517
   Churchward-Venne TA, 2015, J AM MED DIR ASSOC, V16, P400, DOI 10.1016/j.jamda.2015.01.071
   Coon JT, 2011, ENVIRON SCI TECHNOL, V45, P1761, DOI 10.1021/es102947t
   Corona G, 2017, EUR UROL, V72, P1000, DOI 10.1016/j.eururo.2017.03.032
   Corona G, 2014, ASIAN J ANDROL, V16, P581, DOI 10.4103/1008-682X.126386
   Corona G, 2013, EUR J ENDOCRINOL, V168, P829, DOI 10.1530/EJE-12-0955
   Craft LL, 2012, CANCER EPIDEM BIOMAR, V21, P3, DOI 10.1158/1055-9965.EPI-11-0634
   De Moor MHM, 2008, ARCH GEN PSYCHIAT, V65, P897, DOI 10.1001/archpsyc.65.8.897
   de Tejada IS, 2005, J SEX MED, V2, P26, DOI 10.1111/j.1743-6109.2005.20103.x
   Dong JY, 2011, J AM COLL CARDIOL, V58, P1378, DOI 10.1016/j.jacc.2011.06.024
   Ekkekakis P, 2011, SPORTS MED, V41, P641, DOI 10.2165/11590680-000000000-00000
   Elkhoury FF, 2017, UROLOGY, V110, P1, DOI 10.1016/j.urology.2017.07.030
   Esfahani SB, 2018, HEALTH PSYCHOL OPEN, V5, DOI 10.1177/2055102918786867
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   Esposito K, 2009, J SEX MED, V6, P243, DOI 10.1111/j.1743-6109.2008.01030.x
   FABBRI A, 1989, PSYCHONEUROENDOCRINO, V14, P103, DOI 10.1016/0306-4530(89)90059-0
   Fan Y, 2018, WORLD J UROL, V36, P1681, DOI 10.1007/s00345-018-2318-3
   Fisher AJ, 2018, P NATL ACAD SCI USA, V115, pE6106, DOI 10.1073/pnas.1711978115
   Förstermann U, 2012, EUR HEART J, V33, P829, DOI 10.1093/eurheartj/ehr304
   Foster C, 2001, J STRENGTH COND RES, V15, P109, DOI 10.1519/00124278-200102000-00019
   Frederick DA, 2007, PSYCHOL MEN MASCULIN, V8, P103, DOI [DOI 10.1037/1524-9220.8.2.103, 10.1037/1524-9220.8.2.103, 10.1037/1524-9220.8.2, DOI 10.1037/15249220.8.2.103]
   Fruhauf S, 2013, ARCH SEX BEHAV, V42, P915, DOI 10.1007/s10508-012-0062-0
   Fry AC, 1997, SPORTS MED, V23, P106, DOI 10.2165/00007256-199723020-00004
   Geniole SN, 2017, HORM BEHAV, V92, P37, DOI 10.1016/j.yhbeh.2016.10.002
   Gerbild H, 2018, SEX MED-UK, V6, P75, DOI 10.1016/j.esxm.2018.02.001
   Gidlow C., 2005, Health Education Journal, V64, P168, DOI 10.1177/001789690506400208
   Gillespie Lesley D, 2012, Cochrane Database Syst Rev, pCD007146, DOI 10.1002/14651858.CD007146.pub3
   Goldfarb AH, 1997, SPORTS MED, V24, P8, DOI 10.2165/00007256-199724010-00002
   Gong BB, 2017, INT UROL NEPHROL, V49, P1731, DOI 10.1007/s11255-017-1644-5
   Gonzalez-Bono E, 2000, AGGRESSIVE BEHAV, V26, P235, DOI 10.1002/(SICI)1098-2337(2000)26:3<235::AID-AB3>3.0.CO;2-L
   Green DJ, 2004, J PHYSIOL-LONDON, V561, P1, DOI 10.1113/jphysiol.2004.068197
   Guh DP, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-88
   Gupta BP, 2011, ARCH INTERN MED, V171, P1797, DOI 10.1001/archinternmed.2011.440
   Hackett G, 2018, J SEX MED, V15, P430, DOI 10.1016/j.jsxm.2018.01.023
   Hallal PC, 2012, LANCET, V380, P247, DOI 10.1016/S0140-6736(12)60646-1
   Hambrecht R, 2003, CIRCULATION, V107, P3152, DOI 10.1161/01.CIR.0000074229.93804.5C
   Hausenblas HA, 2006, PSYCHOL HEALTH, V21, P33, DOI 10.1080/14768320500105270
   Hawley JA, 2014, CELL, V159, P738, DOI 10.1016/j.cell.2014.10.029
   Hedon F, 2003, INT J IMPOT RES, V15, pS16, DOI 10.1038/sj.ijir.3900994
   Hooper DR, 2017, SPORTS MED, V47, P1709, DOI 10.1007/s40279-017-0698-y
   Ioakeimidis N, 2014, J CARDIOVASC PHARM T, V19, P53, DOI 10.1177/1074248413504034
   Isidori AM, 2014, EUR UROL, V65, P99, DOI 10.1016/j.eururo.2013.08.048
   Jansons PS, 2017, CLIN REHABIL, V31, P465, DOI 10.1177/0269215516653995
   Jones TW, 2016, J STRENGTH COND RES, V30, P693, DOI 10.1519/JSC.0000000000001135
   Jungersten L, 1997, J APPL PHYSIOL, V82, P760, DOI 10.1152/jappl.1997.82.3.760
   Kalka D, 2016, ANATOL J CARDIOL, V16, P256, DOI [10.5152/ AnatolJCardiol.2015.6122, 10.5152/AnatolJCardiol.2015.6122]
   Kalka D, 2015, AM J MENS HEALTH, V9, P360, DOI 10.1177/1557988314544156
   Kalka D, 2013, KARDIOL POL, V71, P573, DOI 10.5603/KP.2013.0120
   Khoo J, 2013, J SEX MED, V10, P1823, DOI 10.1111/jsm.12154
   Kobori Y, 2009, INT J IMPOT RES, V21, P207, DOI 10.1038/ijir.2009.14
   Kouidrat Y, 2017, DIABETIC MED, V34, P1185, DOI 10.1111/dme.13403
   Kyu HH, 2016, BMJ-BRIT MED J, V354, DOI 10.1136/bmj.i3857
   La Vignera S, 2011, AGING MALE, V14, P265, DOI 10.3109/13685538.2010.544344
   Lamina S, 2009, J CLIN HYPERTENS, V11, P125, DOI 10.1111/j.1751-7176.2009.00086.x
   Landers D.M., 2007, HDB SPORT PSYCHOL, P469, DOI DOI 10.1002/9781118270011.CH21
   Lee IM, 2008, MED SCI SPORT EXER, V40, pS512, DOI 10.1249/MSS.0b013e31817c65d0
   Liu Q, 2018, J SEX MED, V15, P1073, DOI 10.1016/j.jsxm.2018.05.016
   Lugg J, 1996, AM J PHYSIOL-ENDOC M, V271, pE354, DOI 10.1152/ajpendo.1996.271.2.E354
   MacDonald AA, 2010, HUM REPROD UPDATE, V16, P293, DOI 10.1093/humupd/dmp047
   Maio G, 2010, J SEX MED, V7, P2201, DOI 10.1111/j.1743-6109.2010.01783.x
   Maiorino MI, 2016, J DIABETES COMPLICAT, V30, P1519, DOI 10.1016/j.jdiacomp.2016.08.007
   Maiorino MI, 2015, ASIAN J ANDROL, V17, P5, DOI 10.4103/1008-682X.137687
   Man LB, 2018, UROLOGY, V119, P97, DOI 10.1016/j.urology.2017.09.011
   Maresca Luigi, 2013, Monaldi Arch Chest Dis, V80, P177
   Maso F, 2004, BRIT J SPORT MED, V38, P260, DOI 10.1136/bjsm.2002.000254
   McCabe M, 2015, J SEX MED, V12, P301, DOI 10.1016/j.jsxm.2015.12.019
   Melanson EL, 2001, EUR J APPL PHYSIOL, V85, P442, DOI 10.1007/s004210100479
   Melnik T, 2008, J SEX MED, V5, P2562, DOI 10.1111/j.1743-6109.2008.00872.x
   Moran LJ, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0161297
   Moyna NM, 2004, ACTA PHYSIOL SCAND, V180, P113, DOI 10.1111/j.0001-6772.2003.01253.x
   Mulhall JP, 2016, INT J CLIN PRACT, V70, P1012, DOI 10.1111/ijcp.12908
   Neufer PD, 2015, CELL METAB, V22, P4, DOI 10.1016/j.cmet.2015.05.011
   Ning L, 2017, ANDROLOGIA, V49, DOI 10.1111/and.12644
   Padilla J, 2008, VASC MED, V13, P105, DOI 10.1177/1358863x07086671
   Padilla J, 2011, PHYSIOLOGY, V26, P132, DOI 10.1152/physiol.00052.2010
   Ponce OJ, 2018, J CLIN ENDOCR METAB, V103, P1745, DOI 10.1210/jc.2018-00404
   Ponholzer A, 2005, EUR UROL, V47, P80, DOI 10.1016/j.eururo.2004.08.017
   POSNER JD, 1992, J AM GERIATR SOC, V40, P1
   Prieto D, 2008, INT J IMPOT RES, V20, P17, DOI 10.1038/sj.ijir.3901581
   Rebar AL, 2015, HEALTH PSYCHOL REV, V9, P366, DOI 10.1080/17437199.2015.1022901
   Reed J, 2009, PSYCHOL SPORT EXERC, V10, P581, DOI 10.1016/j.psychsport.2009.05.009
   Ronay R, 2010, SOC PSYCHOL PERS SCI, V1, P57, DOI 10.1177/1948550609352807
   Rosenbaum S, 2015, PSYCHIAT RES, V230, P130, DOI 10.1016/j.psychres.2015.10.017
   Rossow LM, 2013, INT J SPORT PHYSIOL, V8, P582, DOI 10.1123/ijspp.8.5.582
   Sabiston CM, 2019, PSYCHOL SPORT EXERC, V42, P48, DOI 10.1016/j.psychsport.2018.12.010
   Sabiston CM, 2016, J SPORT EXERCISE PSY, V38, P105, DOI 10.1123/jsep.2015-0175
   Salvador A, 2009, NEUROSCI BIOBEHAV R, V33, P160, DOI 10.1016/j.neubiorev.2008.09.005
   SantaBarbara NJ, 2017, J STRENGTH COND RES, V31, P2880, DOI 10.1519/JSC.0000000000002135
   Schmidt HM, 2014, J SEX MED, V11, P1376, DOI 10.1111/jsm.12520
   Schoenfeld BJ, 2016, SPORTS MED, V46, P1689, DOI 10.1007/s40279-016-0543-8
   Schuch FB, 2018, AM J PSYCHIAT, V175, P631, DOI 10.1176/appi.ajp.2018.17111194
   Shamloul R, 2013, LANCET, V381, P153, DOI 10.1016/S0140-6736(12)60520-0
   Silva AB, 2017, BRIT J SPORT MED, V51, P1419, DOI 10.1136/bjsports-2016-096418
   Slimani M, 2018, BIOL SPORT, V35, P121, DOI 10.5114/biolsport.2018.71601
   Stanton AM, 2018, SEX MED REV, V6, P548, DOI 10.1016/j.sxmr.2018.02.004
   Steib S, 2010, MED SCI SPORT EXER, V42, P902, DOI 10.1249/MSS.0b013e3181c34465
   Steptoe A, 2012, NAT REV CARDIOL, V9, P360, DOI 10.1038/nrcardio.2012.45
   Stubbs B, 2017, PSYCHIAT RES, V249, P102, DOI 10.1016/j.psychres.2016.12.020
   Svartberg J, 2003, EUR J ENDOCRINOL, V149, P145, DOI 10.1530/eje.0.1490145
   Travison TG, 2007, J CLIN ENDOCR METAB, V92, P549, DOI 10.1210/jc.2006-1859
   Travison TG, 2017, J CLIN ENDOCR METAB, V102, P1161, DOI 10.1210/jc.2016-2935
   Vlachopoulos CV, 2013, CIRC-CARDIOVASC QUAL, V6, P99, DOI 10.1161/CIRCOUTCOMES.112.966903
   Waldorf M, 2017, SPORT EXERC PERFORM, V6, P53, DOI 10.1037/spy0000076
   Wang WY, 2017, SEX MED-UK, V5, pE19, DOI 10.1016/j.esxm.2016.10.001
   Warburton DER, 2017, CURR OPIN CARDIOL, V32, P541, DOI 10.1097/HCO.0000000000000437
   White M, 2010, J ENVIRON PSYCHOL, V30, P482, DOI 10.1016/j.jenvp.2010.04.004
   WHO, 2010, SCREENING DONATED BLOOD FOR TRANSFUSION: TRANSMISSIBLE INFECTIONS, P1
   Wilmot EG, 2012, DIABETOLOGIA, V55, P2895, DOI 10.1007/s00125-012-2677-z
   Woertman L, 2012, J SEX RES, V49, P184, DOI 10.1080/00224499.2012.658586
   Wood RI, 2012, HORM BEHAV, V61, P147, DOI 10.1016/j.yhbeh.2011.09.010
   Woodman CR, 1997, AM J PHYSIOL-HEART C, V273, pH2575, DOI 10.1152/ajpheart.1997.273.6.H2575
   Woodward Thomas W, 2009, WMJ, V108, P40
   Yuan JQ, 2013, EUR UROL, V63, P902, DOI 10.1016/j.eururo.2013.01.012
NR 147
TC 26
Z9 30
U1 0
U2 19
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 1759-4812
EI 1759-4820
J9 NAT REV UROL
JI Nat. Rev. Urol.
PD SEP
PY 2019
VL 16
IS 9
BP 553
EP 562
DI 10.1038/s41585-019-0210-6
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Urology & Nephrology
GA IV6JR
UT WOS:000484375200008
PM 31239541
DA 2025-06-11
ER

PT J
AU Memaj, P
   Jornayvaz, FR
AF Memaj, Plator
   Jornayvaz, Francois R.
TI Non-alcoholic fatty liver disease in type 1 diabetes: Prevalence and
   pathophysiology
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE NAFLD; type 1 diabetes; glycogenic hepatopathy; prevalence;
   pathophysiology
ID GLYCOGENIC HEPATOPATHY; INSULIN-RESISTANCE; COMPLICATION; PRAMLINTIDE;
   CLEARANCE; SECRETION; CIRRHOSIS; WEIGHT
AB Non-alcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease in the general population with a global prevalence of 25%. It is often associated with metabolic syndrome and type 2 diabetes, as insulin resistance and hyperinsulinemia are known to be favoring factors. Recent studies have described growing incidence of NAFLD in type 1 diabetes (T1D) as well. Although increasing prevalence of metabolic syndrome in these patients seems to explain part of this increase in NAFLD, other underlying mechanisms may participate in the emergence of NAFLD. Notably, some genetic factors are more associated with fatty liver disease, but their prevalence in T1D has not been evaluated. Moreover, oxidative stress, poor glucose control and long-lasting hyperglycemia, as well as exogenous insulin administration play an important role in intrahepatic fat homeostasis. The main differential diagnosis of NAFLD in T1D is glycogenic hepatopathy, which needs to be considered mostly in T1D patients with poor glycemic control. This article aims to review the prevalence and pathophysiology of NAFLD in T1D and open perspectives for clinicians taking care of T1D patients with potential hepatopathy.
C1 [Memaj, Plator; Jornayvaz, Francois R.] Geneva Univ Hosp, Dept Med, Div Endocrinol, Diabet, Geneva, Switzerland.
   [Jornayvaz, Francois R.] Univ Geneva, Fac Med, Diabet Ctr, Geneva, Switzerland.
   [Jornayvaz, Francois R.] Univ Geneva, Fac Med, Dept Cell Physiol & Metab, Geneva, Switzerland.
C3 University of Geneva; University of Geneva; University of Geneva
RP Jornayvaz, FR (corresponding author), Geneva Univ Hosp, Dept Med, Div Endocrinol, Diabet, Geneva, Switzerland.; Jornayvaz, FR (corresponding author), Univ Geneva, Fac Med, Diabet Ctr, Geneva, Switzerland.; Jornayvaz, FR (corresponding author), Univ Geneva, Fac Med, Dept Cell Physiol & Metab, Geneva, Switzerland.
EM francois.jornayvaz@hcuge.ch
RI Jornayvaz, François/AAL-2134-2020
OI Jornayvaz, Francois/0000-0001-9425-3137
CR Asrih M, 2015, MOL CELL ENDOCRINOL, V418, P55, DOI 10.1016/j.mce.2015.02.018
   Asrih M, 2013, J ENDOCRINOL, V218, pR25, DOI 10.1530/JOE-13-0201
   Bertolio R, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-09152-7
   Blaslov K, 2015, J DIABETES, V7, P340, DOI 10.1111/1753-0407.12194
   Bovi APD, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.595371
   Bril F, 2014, HEPATOLOGY, V59, P2178, DOI 10.1002/hep.26988
   Bumbu A, 2018, DIABETES OBES METAB, V20, P1289, DOI 10.1111/dom.13197
   Chiang JL, 2014, DIABETES CARE, V37, P2034, DOI 10.2337/dc14-1140
   Cotter TG, 2020, GASTROENTEROLOGY, V158, P1851, DOI 10.1053/j.gastro.2020.01.052
   de Vries M, 2022, EUR J INTERN MED, V100, P77, DOI 10.1016/j.ejim.2022.03.025
   de Vries M, 2020, J CLIN ENDOCR METAB, V105, DOI 10.1210/clinem/dgaa575
   DeBose-Boyd RA, 2018, TRENDS BIOCHEM SCI, V43, P358, DOI 10.1016/j.tibs.2018.01.005
   Dif N, 2006, BIOCHEM J, V400, P179, DOI 10.1042/BJ20060499
   Fineman M, 2002, HORM METAB RES, V34, P504, DOI 10.1055/s-2002-34790
   FLATT JP, 1995, AM J CLIN NUTR, V61, p952S, DOI 10.1093/ajcn/61.4.952S
   Galsgaard KD, 2020, J CLIN MED, V9, DOI 10.3390/jcm9124049
   Galsgaard KD, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00413
   Gariani K, 2013, DIABETES METAB, V39, P16, DOI 10.1016/j.diabet.2012.11.002
   Gariani K, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10071747
   Harman DJ, 2014, HEPATOLOGY, V60, P158, DOI 10.1002/hep.27098
   Iizuka K, 2008, ENDOCR J, V55, P617, DOI 10.1507/endocrj.K07E-110
   Kanwal F, 2020, HEPATOLOGY, V71, P808, DOI 10.1002/hep.31014
   Kanwal F, 2018, GASTROENTEROLOGY, V155, P1828, DOI 10.1053/j.gastro.2018.08.024
   Katsarou A, 2017, NAT REV DIS PRIMERS, V3, DOI 10.1038/nrdp.2017.16
   Kinner S, 2016, DIGEST DIS SCI, V61, P1337, DOI 10.1007/s10620-016-4037-1
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Kupriyanova Y, 2021, J HEPATOL, V74, P1028, DOI 10.1016/j.jhep.2020.11.030
   Leeds JS, 2009, DIABETIC MED, V26, P1235, DOI 10.1111/j.1464-5491.2009.02839.x
   Liu WX, 2021, EUR J NUTR, V60, P2317, DOI 10.1007/s00394-020-02431-w
   Liu Y, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-47687-3
   Lugari R, 2000, HORM METAB RES, V32, P424, DOI 10.1055/s-2007-978665
   Madhu S V, 2013, Indian J Endocrinol Metab, V17, P764, DOI 10.4103/2230-8210.113780
   Mantovani A, 2021, METABOLITES, V11, DOI 10.3390/metabo11020073
   Mertens J, 2021, THER ADV ENDOCRINOL, V12, DOI 10.1177/20420188211055557
   Mertens J, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.768576
   Najjar SM, 2019, PHYSIOLOGY, V34, P198, DOI 10.1152/physiol.00048.2018
   Nascè A, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11061131
   Paik JM, 2020, HEPATOLOGY, V72, P1605, DOI 10.1002/hep.31173
   Petit JM, 2015, DIABETIC MED, V32, P1648, DOI 10.1111/dme.12805
   Polyzos SA, 2019, METABOLISM, V92, P82, DOI 10.1016/j.metabol.2018.11.014
   Powell EE, 2021, LANCET, V397, P2212, DOI 10.1016/S0140-6736(20)32511-3
   Priya G, 2018, DIABETES THER, V9, P349, DOI 10.1007/s13300-017-0333-9
   Pyle L, 2021, DIABETOLOGIA, V64, P1709, DOI 10.1007/s00125-021-05480-w
   Regnell Simon E, 2011, Rev Diabet Stud, V8, P454, DOI 10.1900/RDS.2011.8.454
   Roeb E, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.634344
   Rojano-Toimil A, 2022, J CLIN MED, V11, DOI 10.3390/jcm11123286
   Rorsman P, 2000, NEWS PHYSIOL SCI, V15, P72
   Saikusa M, 2013, PEDIATR INT, V55, P806, DOI 10.1111/ped.12235
   Sanyal AJ, 2006, HEPATOLOGY, V43, P682, DOI 10.1002/hep.21103
   Serdarova M, 2022, DIABETES RES CLIN PR, V186, DOI 10.1016/j.diabres.2022.109819
   Shabalala SC, 2020, BIOMED PHARMACOTHER, V131, DOI 10.1016/j.biopha.2020.110785
   Sherigar JM, 2018, WORLD J HEPATOL, V10, P172, DOI 10.4254/wjh.v10.i2.172
   Shi YW, 2020, J CLIN GASTROENTEROL, V54, P378, DOI 10.1097/MCG.0000000000001270
   Singh-Franco D, 2007, CLIN THER, V29, P535, DOI 10.1016/j.clinthera.2007.04.005
   Steck AK, 2011, CLIN CHEM, V57, P176, DOI 10.1373/clinchem.2010.148221
   Syed FZ, 2022, ANN INTERN MED, V175, pITC33, DOI 10.7326/AITC202203150
   Targher G, 2020, GUT, V69, P1691, DOI 10.1136/gutjnl-2020-320622
   Thivolet C, 2019, DIABETOLOGIA, V62, P593, DOI 10.1007/s00125-018-4804-y
   Torbenson M, 2006, AM J SURG PATHOL, V30, P508, DOI 10.1097/00000478-200604000-00012
   Unger RH, 2010, P NATL ACAD SCI USA, V107, P16009, DOI 10.1073/pnas.1006639107
   Vilsboll T, 2003, J CLIN ENDOCR METAB, V88, P2706, DOI 10.1210/jc.2002-021873
   Wu SQ, 2016, SCI REP-UK, V6, DOI 10.1038/srep33386
   Younossi Z, 2019, HEPATOLOGY, V69, P2672, DOI 10.1002/hep.30251
   Younossi ZM, 2019, J HEPATOL, V71, P793, DOI 10.1016/j.jhep.2019.06.021
   Zibar K, 2015, ANN CLIN BIOCHEM, V52, P220, DOI 10.1177/0004563214544709
NR 65
TC 17
Z9 18
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD DEC 1
PY 2022
VL 13
AR 1031633
DI 10.3389/fendo.2022.1031633
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 7A3XB
UT WOS:000898392300001
PM 36531463
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Li, YH
   Zheng, NN
   Ding, XD
AF Li, Yunhao
   Zheng, Ningning
   Ding, Xudong
TI Mitophagy Disequilibrium, a Prominent Pathological Mechanism in
   Metabolic Heart Diseases
SO DIABETES METABOLIC SYNDROME AND OBESITY
LA English
DT Review
DE mitophagy; metabolic heart diseases; metabolic syndrome; PTEN induced
   putative kinase; PINK; parkin; Bcl-2; BNIP3; FUN14 domain-containing
   protein 1; FUNDC1; ferroptosis
ID CATHEPSIN-D; CELL-DEATH; MITOCHONDRIAL DYSFUNCTION; CARDIAC DYSFUNCTION;
   MEDIATED MITOPHAGY; OXIDATIVE STRESS; E3 LIGASE; AUTOPHAGY; PROTEIN;
   MTOR
AB With overall food intake among the general population as high as ever, metabolic syndrome (MetS) has become a global epidemic and is responsible for many serious life threatening diseases, especially heart failure. In multiple metabolic disorders, maintaining a dynamic balance of mitochondrial number and function is necessary to prevent the overproduction of reactive oxygen species (ROS), which has been proved to be one of the important mechanisms of cardiomyocyte injury due to the mismatching of oxygen consumption and mitochondrial population and finally to heart failure. Mitophagy is a process that eliminates damaged or redundant mitochondria. It is mediated by a series of signaling molecules, including PINK, parkin, BINP3, FUNDC1, CTSD, Drp1, Rab9 and mTOR. Meanwhile, increasing evidence also showed that the interaction between ferroptosis and mitophagy interfered with mitochondrial homeostasis. This review will focus on these essential molecules and pathways of mitophagy and cell homeostasis affected by hypoxia and other stimuli in metabolic heart diseases.
C1 [Li, Yunhao] China Med Univ, Clin Coll 1, Shenyang, Liaoning, Peoples R China.
   [Zheng, Ningning] China Med Univ, Coll Basic Med Sci, Dept Pathophysiol, Shenyang, Liaoning, Peoples R China.
   [Ding, Xudong] China Med Univ, Dept Anesthesiol, Shengjing Hosp, 36 Sanhao St, Shenyang 110004, Liaoning, Peoples R China.
C3 China Medical University; China Medical University; China Medical
   University
RP Ding, XD (corresponding author), China Med Univ, Dept Anesthesiol, Shengjing Hosp, 36 Sanhao St, Shenyang 110004, Liaoning, Peoples R China.
EM dingxd@sj-hospital.org
RI Zheng, Ningning/KHU-0389-2024; Li, Yunhao/HCI-0205-2022
OI Li, Yunhao/0000-0002-5359-2930
FU National Natural Science Foundation of China [81800763]; Natural Science
   Foundation of Liaoning Province of China [20180551076, 2013021046]
FX The work was supported by the National Natural Science Foundation of
   China (FUND#81800763), the Natural Science Foundation of Liaoning
   Province of China (FUND#20180551076) and the Natural Science Foundation
   of Liaoning Province of China (FUND#2013021046).
CR Ambivero CT, 2014, CELL SIGNAL, V26, P2921, DOI 10.1016/j.cellsig.2014.09.004
   Baba Y, 2018, AM J PHYSIOL-HEART C, V314, pH659, DOI 10.1152/ajpheart.00452.2017
   Bae SH, 2012, CELL RES, V22, P873, DOI 10.1038/cr.2012.38
   Basit F, 2017, CELL DEATH DIS, V8, DOI 10.1038/cddis.2017.133
   Benissan-Messan DZ, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.583393
   Bloomgarden Z, 2018, J DIABETES, V10, P350, DOI 10.1111/1753-0407.12645
   Bozkurt B, 2016, CIRCULATION, V134, pE535, DOI 10.1161/CIR.0000000000000450
   Braschi E, 2009, EMBO REP, V10, P748, DOI 10.1038/embor.2009.86
   Cao K, 2014, FREE RADICAL BIO MED, V67, P396, DOI 10.1016/j.freeradbiomed.2013.11.029
   Chen G, 2014, MOL CELL, V54, P362, DOI 10.1016/j.molcel.2014.02.034
   Chen XQ, 2019, BIOCHEM BIOPH RES CO, V516, P37, DOI 10.1016/j.bbrc.2019.06.015
   Chen ZH, 2017, AUTOPHAGY, V13, P1244, DOI 10.1080/15548627.2017.1310789
   Chen ZH, 2017, EMBO REP, V18, P495, DOI 10.15252/embr.201643309
   Comitato A, 2014, INVEST OPHTH VIS SCI, V55, P3555, DOI 10.1167/iovs.14-13917
   Conus S, 2008, J EXP MED, V205, P685, DOI 10.1084/jem.20072152
   Conus S, 2012, J BIOL CHEM, V287, P21142, DOI 10.1074/jbc.M111.306399
   De Matteis S, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20061503
   Di Domenico F, 2016, EXPERT OPIN THER TAR, V20, P1393, DOI 10.1080/14728222.2016.1252334
   Di Rita A, 2018, FRONT CELL NEUROSCI, V12, DOI 10.3389/fncel.2018.00092
   Dominic EA, 2014, HEART, V100, P611, DOI 10.1136/heartjnl-2013-304657
   Fang XX, 2019, P NATL ACAD SCI USA, V116, P2672, DOI 10.1073/pnas.1821022116
   Gao MH, 2016, CELL RES, V26, P1021, DOI 10.1038/cr.2016.95
   Ge ZD, 2019, INT HEART J, V60, P512, DOI 10.1536/ihj.18-476
   Hanna RA, 2012, J BIOL CHEM, V287, P19094, DOI 10.1074/jbc.M111.322933
   Hoshino A, 2014, P NATL ACAD SCI USA, V111, P3116, DOI 10.1073/pnas.1318951111
   Hou W, 2016, AUTOPHAGY, V12, P1425, DOI 10.1080/15548627.2016.1187366
   Hsieh YC, 2009, TRENDS MOL MED, V15, P129, DOI 10.1016/j.molmed.2009.01.002
   Hu XL, 2018, BBA-MOL BASIS DIS, V1864, P1984, DOI 10.1016/j.bbadis.2017.10.013
   Itakura E, 2009, AUTOPHAGY, V5, P534, DOI 10.4161/auto.5.4.8062
   Jung J, 2019, CANCER RES, V79, P5218, DOI 10.1158/0008-5472.CAN-19-0198
   Kabeya Y, 2000, EMBO J, V19, P5720, DOI 10.1093/emboj/19.21.5720
   Kageyama Y, 2014, EMBO J, V33, P2798, DOI 10.15252/embj.201488658
   Karbowski M, 2002, J CELL BIOL, V159, P931, DOI 10.1083/jcb.200209124
   Khamzina L, 2005, ENDOCRINOLOGY, V146, P1473, DOI 10.1210/en.2004-0921
   Kim I, 2007, ARCH BIOCHEM BIOPHYS, V462, P245, DOI 10.1016/j.abb.2007.03.034
   Koch S, 2013, NEUROBIOL DIS, V50, P107, DOI 10.1016/j.nbd.2012.10.004
   Kuhikar R, 2020, STEM CELL RES THER, V11, DOI 10.1186/s13287-020-01603-z
   Lampert MA, 2019, AUTOPHAGY, V15, P1182, DOI 10.1080/15548627.2019.1580095
   Laurent-Matha V, 2012, FASEB J, V26, P5172, DOI 10.1096/fj.12-205229
   Lazarou M, 2013, J CELL BIOL, V200, P163, DOI 10.1083/jcb.201210111
   Lee H, 2020, NAT CELL BIOL, V22, DOI 10.1038/s41556-020-0461-8
   Li AX, 2022, HEART FAIL REV, V27, P1387, DOI 10.1007/s10741-021-10109-6
   Li W, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001487
   Li WY, 2020, DNA CELL BIOL, V39, P210, DOI 10.1089/dna.2019.5097
   Liang CY, 2008, NAT CELL BIOL, V10, P776, DOI 10.1038/ncb1740
   Lim H, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-03939-w
   Liu FH, 2015, CIRCULATION, V131, P795, DOI 10.1161/CIRCULATIONAHA.114.012285
   Liu KE, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0129667
   Liu L, 2014, CELL RES, V24, P787, DOI 10.1038/cr.2014.75
   Liu L, 2012, NAT CELL BIOL, V14, P177, DOI 10.1038/ncb2422
   Liu M, 2021, MOL ONCOL, V15, P2084, DOI 10.1002/1878-0261.12936
   Ma H, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0124128
   McHugh K, 2019, J AM COLL CARDIOL, V73, P602, DOI 10.1016/j.jacc.2018.11.033
   Meijer Alfred J., 2006, Molecular Aspects of Medicine, V27, P411, DOI 10.1016/j.mam.2006.08.002
   Meyer G, 2013, CURR PHARM DESIGN, V19, P6912, DOI 10.2174/138161281939131127122510
   Mizushima N, 2005, CELL DEATH DIFFER, V12, P1535, DOI 10.1038/sj.cdd.4401728
   Mizushima N, 2010, CELL, V140, P313, DOI 10.1016/j.cell.2010.01.028
   Morciano G, 2022, CARDIOVASC RES, V118, P2548, DOI 10.1093/cvr/cvab267
   Morciano G, 2021, LIFE-BASEL, V11, DOI 10.3390/life11050436
   Moskal N, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-019-13781-3
   Nadruz W, 2015, J HUM HYPERTENS, V29, P1, DOI 10.1038/jhh.2014.36
   Narendra DP, 2010, PLOS BIOL, V8, DOI 10.1371/journal.pbio.1000298
   Noda T, 2009, CELL DEATH DIFFER, V16, P984, DOI 10.1038/cdd.2009.54
   Novak I, 2010, EMBO REP, V11, P45, DOI 10.1038/embor.2009.256
   Okuno T, 2018, CANCERS, V10, DOI 10.3390/cancers10120465
   Pei ZH, 2021, METABOLISM, V122, DOI 10.1016/j.metabol.2021.154840
   Poncelas M, 2015, J MOL CELL CARDIOL, V84, P154, DOI 10.1016/j.yjmcc.2015.04.023
   Puri R, 2020, AUTOPHAGY, V16, P176, DOI 10.1080/15548627.2019.1687216
   Puri R, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-11636-5
   Qu H, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600338
   Ravingerová T, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21217889
   Ren J, 2020, SCI ADV, V6, DOI 10.1126/sciadv.abc8561
   Rogov VV, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-01258-6
   Roperto S, 2019, VET MICROBIOL, V236, DOI 10.1016/j.vetmic.2019.108396
   SAFTIG P, 1995, EMBO J, V14, P3599, DOI 10.1002/j.1460-2075.1995.tb00029.x
   Saito T, 2019, J CLIN INVEST, V129, P802, DOI 10.1172/JCI122035
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sandoval H, 2008, NATURE, V454, P232, DOI 10.1038/nature07006
   Sassone J, 2010, CELL DEATH DIS, V1, DOI 10.1038/cddis.2009.6
   Schweers RL, 2007, P NATL ACAD SCI USA, V104, P19500, DOI 10.1073/pnas.0708818104
   Sciarretta S, 2018, CIRC RES, V122, P489, DOI 10.1161/CIRCRESAHA.117.311147
   Shirakabe A, 2016, CIRCULATION, V133, P1249, DOI 10.1161/CIRCULATIONAHA.115.020502
   Smirnova E, 1998, J CELL BIOL, V143, P351, DOI 10.1083/jcb.143.2.351
   Song RS, 2013, NATURE, V494, P375, DOI 10.1038/nature11834
   Sun XD, 2020, DIABETES, V69, P1292, DOI 10.2337/db19-0991
   Tanida I, 2004, J BIOL CHEM, V279, P47704, DOI 10.1074/jbc.M407016200
   Tong MM, 2019, CIRC RES, V124, P1360, DOI 10.1161/CIRCRESAHA.118.314607
   Uchinaka A, 2017, PHARMACOL RES PERSPE, V5, DOI 10.1002/prp2.331
   VanWagner LB, 2015, HEPATOLOGY, V62, P773, DOI 10.1002/hep.27869
   Vashishta Aruna, 2009, Endocrine Metabolic & Immune Disorders-Drug Targets, V9, P385
   Villa E, 2018, TRENDS CELL BIOL, V28, P882, DOI 10.1016/j.tcb.2018.07.004
   Wada J, 2016, ACTA MED OKAYAMA, V70, P151
   Wang CY, 2020, J CELL MOL MED, V24, P6670, DOI 10.1111/jcmm.15318
   Wang J, 2020, REDOX BIOL, V30, DOI 10.1016/j.redox.2019.101415
   Wang J, 2016, CELL SIGNAL, V28, P1099, DOI 10.1016/j.cellsig.2016.05.007
   Wang N, 2021, J MOL CELL CARDIOL, V150, P65, DOI 10.1016/j.yjmcc.2020.10.010
   Wu HK, 2019, CIRCULATION, V139, P901, DOI 10.1161/CIRCULATIONAHA.118.037216
   Wu HK, 2020, AUTOPHAGY, V16, P683, DOI [10.1080/15548627.2019.1635380, 10.1080/15548627.2019.1596482]
   Wu JX, 2006, BIOCHEM BIOPH RES CO, V339, P437, DOI 10.1016/j.bbrc.2005.10.211
   Wu PL, 2017, CIRC-HEART FAIL, V10, DOI 10.1161/CIRCHEARTFAILURE.117.004044
   Wu WW, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0132499
   Wu WX, 2016, EMBO J, V35, P1368, DOI 10.15252/embj.201593102
   Xue RQ, 2019, FREE RADICAL BIO MED, V134, P119, DOI 10.1016/j.freeradbiomed.2019.01.011
   Yu WJ, 2017, BBA-MOL BASIS DIS, V1863, P1973, DOI 10.1016/j.bbadis.2016.10.021
   Yun JN, 2014, ELIFE, V3, DOI 10.7554/eLife.01958
   Zhang J, 2009, CELL DEATH DIFFER, V16, P939, DOI 10.1038/cdd.2009.16
   Zhang XY, 2020, NAT METAB, V2, P110, DOI 10.1038/s42255-019-0162-4
   Zhang YM, 2013, AUTOPHAGY, V9, P939, DOI 10.4161/auto.24398
   Zhao CY, 2017, ONCOTARGET, V8, P20988, DOI 10.18632/oncotarget.15470
   Zhu YY, 2013, J BIOL CHEM, V288, P1099, DOI 10.1074/jbc.M112.399345
NR 110
TC 11
Z9 11
U1 6
U2 28
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2021
VL 14
BP 4631
EP 4640
DI 10.2147/DMSO.S336882
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA XE2SE
UT WOS:000723243000003
PM 34858041
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Burgess, A
   Vanella, L
   Bellner, L
   Schwartzman, ML
   Abraham, NG
AF Burgess, Angela
   Vanella, Luca
   Bellner, Lars
   Schwartzman, Michal L.
   Abraham, Nader G.
TI Epoxyeicosatrienoic acids and heme oxygenase-1 interaction attenuates
   diabetes and metabolic syndrome complications
SO PROSTAGLANDINS & OTHER LIPID MEDIATORS
LA English
DT Review
DE MSC; EET-agonist; HO-1; pAKT; Adipocyte
ID ACTIVATED PROTEIN-KINASE; IMPROVES INSULIN SENSITIVITY;
   ISCHEMIA-REPERFUSION INJURY; INCREASES ADIPONECTIN LEVELS; VISCERAL
   ADIPOSE-TISSUE; MESENCHYMAL STEM-CELLS; OXIDATIVE STRESS;
   ARACHIDONIC-ACID; CARBON-MONOXIDE; AUTOIMMUNE-DISEASES
AB MSCs are considered to be the natural precursors to adipocyte development through the process of adipogenesis. A link has been established between decreased protective effects of EETs or HO-1 and their interaction in metabolic syndrome. Decreases in HO-1 or EET were associated with an increase in adipocyte stem cell differentiation and increased levels of inflammatory cytokines. EET agonist (AKR-I-27-28) inhibited MSC-derived adipocytes and decreased the levels of inflammatory cytokines. We further describe the role of CYP-epoxygenase expression, HO expression, and circulating cytokine levels in an obese mouse, ob/ob(-/-) mouse model. Ex vivo measurements of EET expression within MSCs derived from ob/ob(-/-) showed decreased levels of EETs that were increased by HO induction. This review demonstrates that suppression of HO and EET systems exist in MSCs prior to the development of adipocyte dysfunction. Further, adipocyte dysfunction can be ameliorated by induction of HO-1 and CYP-epoxygenase, i.e. EET. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Burgess, Angela; Vanella, Luca; Abraham, Nader G.] Univ Toledo, Dept Physiol & Pharmacol, Coll Med, Toledo, OH 43614 USA.
   [Bellner, Lars; Schwartzman, Michal L.] New York Med Coll, Dept Pharmacol, Valhalla, NY 10595 USA.
C3 University System of Ohio; University of Toledo; New York Medical
   College
RP Abraham, NG (corresponding author), Univ Toledo, Dept Physiol & Pharmacol, Coll Med, Toledo, OH 43614 USA.
EM Nader.Abraham@utoledo.edu
RI Vanella, Luca/J-7354-2016
OI Vanella, Luca/0000-0002-6314-6029
FU NHLBI NIH HHS [P01 HL034300] Funding Source: Medline; NIDDK NIH HHS [R01
   DK056601, R01 DK068134] Funding Source: Medline
CR Abraham NG, 2008, CURR PHARM DESIGN, V14, P412, DOI 10.2174/138161208783597371
   Abraham NG, 2008, PHARMACOL REV, V60, P79, DOI 10.1124/pr.107.07104
   Abraham NG, 2008, J AUTOIMMUN, V30, P128, DOI 10.1016/j.jaut.2007.12.005
   ABRAHAM NG, 1989, BLOOD, V74, P139
   ABRAHAM NG, 1991, INT J CELL CLONING, V9, P185, DOI 10.1002/stem.5530090304
   Abraham NG, 2005, FREE RADICAL BIO MED, V39, P1, DOI 10.1016/j.freeradbiomed.2005.03.010
   ABRAHAM NG, 1991, BLOOD, V78, P1461
   Abraham NG, 1996, ENVIRON HEALTH PERSP, V104, P1277, DOI 10.2307/3433176
   ABRAHAM NG, 1991, BLOOD REV, V5, P19, DOI 10.1016/0268-960X(91)90004-V
   ABRAHAM NG, 1993, EXP HEMATOL, V21, P263
   Abraham NG, 1996, CELL PHYSIOL BIOCHEM, V6, P129, DOI 10.1159/000154819
   ABRAHAM NG, 1983, PROGR HEMATOLOGY, P75
   Bailey ST, 2005, NAT IMMUNOL, V6, P966, DOI 10.1038/ni1005-966
   Bao W, 2010, AM J EPIDEMIOL, V172, P631, DOI 10.1093/aje/kwq162
   BAYNES JW, 1991, DIABETES, V40, P405, DOI 10.2337/diabetes.40.4.405
   Blühre M, 2009, EXP CLIN ENDOCR DIAB, V117, P241, DOI 10.1055/s-0029-1192044
   BROWN A, 1987, BLOOD CELLS, V13, P123
   Bruce CR, 2003, DIABETES, V52, P2338, DOI 10.2337/diabetes.52.9.2338
   Bulhak AA, 2009, AM J PHYSIOL-HEART C, V296, pH719, DOI 10.1152/ajpheart.00394.2008
   Burgess A, 2010, HYPERTENSION, V56, P1124, DOI 10.1161/HYPERTENSIONAHA.110.151423
   Campbell WB, 2007, HYPERTENSION, V49, P590, DOI 10.1161/01.HYP.0000255173.50317.fc
   Cao JA, 2011, HUM GENE THER, V22, P271, DOI 10.1089/hum.2010.059
   Cao J, 2009, INT J BIOCHEM CELL B, V41, P1025, DOI 10.1016/j.biocel.2008.10.025
   Capdevila JH, 2007, KIDNEY INT, V72, P683, DOI 10.1038/sj.ki.5002394
   CAPDEVILA JH, 1992, FASEB J, V6, P731, DOI 10.1096/fasebj.6.2.1537463
   Chen K, 2008, J CELL BIOL, V181, P1129, DOI 10.1083/jcb.200709049
   Chen SF, 2005, P NATL ACAD SCI USA, V102, P7251, DOI 10.1073/pnas.0502407102
   CHERTKOV JL, 1993, STEM CELLS, V11, P218, DOI 10.1002/stem.5530110309
   CHERTKOV JL, 1991, EXP HEMATOL, V19, P905
   Dai D, 2001, PHARMACOGENETICS, V11, P597, DOI 10.1097/00008571-200110000-00006
   daSilva JL, 1996, J LAB CLIN MED, V128, P290, DOI 10.1016/S0022-2143(96)90030-X
   De Taeye BM, 2010, OBESITY, V18, P489, DOI 10.1038/oby.2009.227
   DeLozier TC, 2004, J PHARMACOL EXP THER, V310, P845, DOI 10.1124/jpet.104.067819
   DeLozier TC, 2007, DRUG METAB DISPOS, V35, P682, DOI 10.1124/dmd.106.012823
   Di Noia MA, 2006, J BIOL CHEM, V281, P15687, DOI 10.1074/jbc.M510595200
   Drechsler Y, 2006, J IMMUNOL, V177, P2592, DOI 10.4049/jimmunol.177.4.2592
   Duncan ER, 2008, DIABETES, V57, P3307, DOI 10.2337/db07-1111
   Durante W, 2003, J CELL PHYSIOL, V195, P373, DOI 10.1002/jcp.10274
   Dzamko NL, 2009, ACTA PHYSIOL, V196, P115, DOI 10.1111/j.1748-1716.2009.01969.x
   Evans JL, 2002, ENDOCR REV, V23, P599, DOI 10.1210/er.2001-0039
   Evans RM, 2004, NAT MED, V10, P355, DOI 10.1038/nm1025
   FALCK JR, 1983, BIOCHEM BIOPH RES CO, V114, P743, DOI 10.1016/0006-291X(83)90843-4
   Fang X, 2006, AM J PHYSIOL-HEART C, V290, pH55, DOI 10.1152/ajpheart.00427.2005
   Farhangkhoee H, 2003, J MOL CELL CARDIOL, V35, P1439, DOI 10.1016/j.yjmcc.2003.09.007
   Fleming I, 2003, THROMB HAEMOSTASIS, V90, P863, DOI 10.1160/TH03-04-0228
   FRIEDENSTEIN AJ, 1974, EXP HEMATOL, V2, P83
   Vázquez-Vela MEF, 2008, ARCH MED RES, V39, P715, DOI 10.1016/j.arcmed.2008.09.005
   Fujio Y, 2000, CIRCULATION, V101, P660, DOI 10.1161/01.CIR.101.6.660
   FURCHGOTT RF, 1991, BLOOD VESSELS, V28, P52
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gesta S, 2007, CELL, V131, P242, DOI 10.1016/j.cell.2007.10.004
   Ghattas MH, 2002, INT J BIOCHEM CELL B, V34, P1619, DOI 10.1016/S1357-2725(02)00097-3
   Goodman AI, 2006, J AM SOC NEPHROL, V17, P1073, DOI 10.1681/ASN.2004121082
   Gregoire FM, 1998, PHYSIOL REV, V78, P783, DOI 10.1152/physrev.1998.78.3.783
   Gurevitch O, 2007, EXP HEMATOL, V35, P128, DOI 10.1016/j.exphem.2006.09.010
   Gustafson B., 2010, J ATHEROSCLER THROMB
   Hardie DG, 2007, ANNU REV PHARMACOL, V47, P185, DOI 10.1146/annurev.pharmtox.47.120505.105304
   Hardie DG, 2003, ENDOCRINOLOGY, V144, P5179, DOI 10.1210/en.2003-0982
   HARRISON J, 1993, BLOOD, V82, P3574
   Horwitz EM, 2005, CYTOTHERAPY, V7, P393, DOI 10.1080/14653240500319234
   IBRAHIM NG, 1981, CLIN PHARMACOL THER, V29, P253
   Ikehara S, 1998, INT J MOL MED, V1, P5
   IKEHARA S, 1990, P NATL ACAD SCI USA, V87, P8341, DOI 10.1073/pnas.87.21.8341
   IKEHARA S, 1994, TOHOKU J EXP MED, V173, P141, DOI 10.1620/tjem.173.141
   IKEHARA S, 1985, P NATL ACAD SCI USA, V82, P7743, DOI 10.1073/pnas.82.22.7743
   Ikehara S, 2010, CLIN REV ALLERG IMMU, V38, P292, DOI 10.1007/s12016-009-8159-5
   Imhoff BR, 2010, DIFFERENTIATION, V80, P31, DOI 10.1016/j.diff.2010.04.005
   Imig JD, 2005, AM J PHYSIOL-RENAL, V289, pF496, DOI 10.1152/ajprenal.00350.2004
   Imig JD, 2000, AM J PHYSIOL-RENAL, V279, pF965, DOI 10.1152/ajprenal.2000.279.6.F965
   Imig JD, 2008, MICROCIRCULATION, V15, P137, DOI 10.1080/10739680701456960
   Ishizaka N, 1997, CIRCULATION, V96, P1923, DOI 10.1161/01.CIR.96.6.1923
   JOHNSON RA, 1995, HYPERTENSION, V25, P166, DOI 10.1161/01.HYP.25.2.166
   Kadowaki T, 2006, J CLIN INVEST, V116, P1784, DOI 10.1172/JCI29126
   Kaneto H, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/453892
   Kearney MT, 2008, EXP PHYSIOL, V93, P158, DOI 10.1113/expphysiol.2007.039172
   Kemp K, 2011, ANN HEMATOL
   Kim DH, 2010, STEM CELLS DEV
   Kim DH, 2008, J PHARMACOL EXP THER, V325, P833, DOI 10.1124/jpet.107.135285
   Kim JY, 2007, J CLIN INVEST, V117, P2621, DOI 10.1172/JCI31021
   Kovacic S, 2003, J BIOL CHEM, V278, P39422, DOI 10.1074/jbc.M305371200
   Krönke G, 2007, ARTERIOSCL THROM VAS, V27, P1276, DOI 10.1161/ATVBAHA.107.142638
   Kruger AL, 2006, J PHARMACOL EXP THER, V319, P1144, DOI 10.1124/jpet.106.107482
   L'Abbate A, 2007, AM J PHYSIOL-HEART C, V293, pH3532, DOI 10.1152/ajpheart.00826.2007
   Lafontan M, 2008, DIABETES METAB, V34, P317, DOI 10.1016/j.diabet.2008.04.001
   LANIADOSCHWARTZMAN M, 1992, PEDIATR NEPHROL, V6, P490, DOI 10.1007/BF00874022
   Larsen BT, 2008, CIRC RES, V102, P59, DOI 10.1161/CIRCRESAHA.107.159129
   Larsen BT, 2007, TRENDS PHARMACOL SCI, V28, P32, DOI 10.1016/j.tips.2006.11.002
   Lefterova MI, 2009, TRENDS ENDOCRIN MET, V20, P107, DOI 10.1016/j.tem.2008.11.005
   Li M, 2008, DIABETES, V57, P1526, DOI 10.2337/db07-1764
   Li M, 2007, ANTIOXID REDOX SIGN, V9, P855, DOI 10.1089/ars.2007.1568
   Li M, 2010, J AUTOIMMUN, V35, P414, DOI 10.1016/j.jaut.2010.09.001
   LOEWY G, 1992, HEMATOL PATHOL, V6, P79
   Longnus SL, 2005, DIABETOLOGIA, V48, P2591, DOI 10.1007/s00125-005-0016-3
   LUTTON JD, 1991, P SOC EXP BIOL MED, V196, P260
   MAINES MD, 1974, P NATL ACAD SCI USA, V71, P4293, DOI 10.1073/pnas.71.11.4293
   MARKS GS, 1991, TRENDS PHARMACOL SCI, V12, P185, DOI 10.1016/0165-6147(91)90544-3
   Martini CN, 2009, MOL CELL ENDOCRINOL, V298, P42, DOI 10.1016/j.mce.2008.10.023
   Mingone CJ, 2006, AM J PHYSIOL-LUNG C, V291, pL337, DOI 10.1152/ajplung.00482.2005
   Morita T, 2005, ARTERIOSCL THROM VAS, V25, P1786, DOI 10.1161/01.ATV.0000178169.95781.49
   Motoshima H, 2002, J CLIN ENDOCR METAB, V87, P5662, DOI 10.1210/JC.2002-020635
   Münzel T, 2010, EUR HEART J, V31, P2741, DOI 10.1093/eurheartj/ehq396
   Murabito JM, 2009, ATHEROSCLEROSIS, V203, P509, DOI 10.1016/j.atherosclerosis.2008.06.031
   Nakatani Y, 2005, J BIOL CHEM, V280, P847, DOI 10.1074/jbc.M411860200
   Ndisang JF, 2002, HYPERTENSION, V40, P315, DOI 10.1161/01.HYP.0000028488.71068.16
   Ndisang JF, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/359732
   Ndisang JF, 2009, ENDOCRINOLOGY, V150, P2627, DOI 10.1210/en.2008-1370
   Nicolai A, 2009, HYPERTENSION, V53, P508, DOI 10.1161/HYPERTENSIONAHA.108.124701
   Node K, 1999, SCIENCE, V285, P1276, DOI 10.1126/science.285.5431.1276
   Norwood S, 2010, AM J TRANSL RES, V2, P447
   Orlandi A, 2010, BASIC RES CARDIOL, V105, P703, DOI 10.1007/s00395-010-0109-0
   Otterbein LE, 2000, NAT MED, V6, P422, DOI 10.1038/74680
   Otterbein LE, 2003, NAT MED, V9, P183, DOI 10.1038/nm817
   Ouchi N, 2004, J BIOL CHEM, V279, P1304, DOI 10.1074/jbc.M310389200
   Ouchi N, 2011, NAT REV IMMUNOL, V11, P85, DOI 10.1038/nri2921
   Peterson SJ, 2008, J LIPID RES, V49, P1658, DOI 10.1194/jlr.M800046-JLR200
   Peterson SJ, 2009, CARDIOL REV, V17, P99, DOI 10.1097/CRD.0b013e31819d813a
   Peterson SJ, 2009, J LIPID RES, V50, P1293, DOI 10.1194/jlr.M800610-JLR200
   Poitout V, 2002, ENDOCRINOLOGY, V143, P339, DOI 10.1210/en.143.2.339
   Pratheeshkumar P., 2010, Inflammopharmacology, V18, P197, DOI 10.1007/s10787-010-0042-8
   Robertson RP, 2007, CELL BIOCHEM BIOPHYS, V48, P139, DOI 10.1007/s12013-007-0026-5
   Roman RJ, 2002, PHYSIOL REV, V82, P131, DOI 10.1152/physrev.00021.2001
   Rosen ED, 2000, GENE DEV, V14, P1293
   Rosen ED, 2006, NAT REV MOL CELL BIO, V7, P885, DOI 10.1038/nrm2066
   Rupnick MA, 2002, P NATL ACAD SCI USA, V99, P10730, DOI 10.1073/pnas.162349799
   Sacerdoti D, 2007, PROSTAG OTH LIPID M, V82, P155, DOI 10.1016/j.prostaglandins.2006.07.001
   Scarborough PE, 1999, DRUG METAB REV, V31, P205, DOI 10.1081/DMR-100101915
   Schulz E, 2008, CIRCULATION, V118, P1347, DOI 10.1161/CIRCULATIONAHA.108.784298
   SCHWARTZMAN M, 1981, J BIOL CHEM, V256, P2329
   SCHWARTZMAN M, 1985, NATURE, V314, P620, DOI 10.1038/314620a0
   SCHWARTZMAN ML, 1990, KIDNEY INT, V37, P94, DOI 10.1038/ki.1990.13
   Shen GX, 2010, CAN J PHYSIOL PHARM, V88, P241, DOI 10.1139/Y10-018
   Shibata R, 2005, NAT MED, V11, P1096, DOI 10.1038/nm1295
   Sodhi K, 2009, J PHARMACOL EXP THER, V331, P906, DOI 10.1124/jpet.109.157545
   Spector AA, 2004, PROG LIPID RES, V43, P55, DOI 10.1016/S0163-7827(03)00049-3
   Spector AA, 2007, AM J PHYSIOL-CELL PH, V292, pC996, DOI 10.1152/ajpcell.00402.2006
   Spiecker M, 2004, CIRCULATION, V110, P2132, DOI 10.1161/01.CIR.0000143832.91812.60
   Stocker R, 2006, CIRCULATION, V114, P2178, DOI 10.1161/CIRCULATIONAHA.105.598698
   Styner M, 2010, J CELL BIOCHEM, V111, P1042, DOI 10.1002/jcb.22793
   Sun JF, 2005, P NATL ACAD SCI USA, V102, P128, DOI 10.1073/pnas.0403198102
   TONTONOZ P, 1994, CELL, V79, P1147, DOI 10.1016/0092-8674(94)90006-X
   Turkseven S, 2007, J CELL BIOCHEM, V100, P815, DOI 10.1002/jcb.21138
   Turkseven S, 2005, AM J PHYSIOL-HEART C, V289, pH701, DOI 10.1152/ajpheart.00024.2005
   Ueda Y, 2007, STEM CELLS, V25, P1356, DOI 10.1634/stemcells.2006-0811
   Vanikar AV, 2010, STEM CELLS INT, V2010, DOI 10.4061/2010/582382
   Wajchenberg BL, 2000, ENDOCR REV, V21, P697, DOI 10.1210/er.21.6.697
   Wang MH, 2003, HYPERTENSION, V42, P594, DOI 10.1161/01.HYP.0000090123.55365.BA
   Wang WZW, 2004, HEPATOLOGY, V40, P424, DOI 10.1002/hep.20334
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Yachie A, 1999, J CLIN INVEST, V103, P129, DOI 10.1172/JCI4165
   Yamauchi T, 2001, J BIOL CHEM, V276, P41245, DOI 10.1074/jbc.M103241200
   Zeldin DC, 2001, J BIOL CHEM, V276, P36059, DOI 10.1074/jbc.R100030200
   Zeldin DC, 1997, ENDOCRINOLOGY, V138, P1338, DOI 10.1210/en.138.3.1338
   Zhang XC, 2003, J BIOL CHEM, V278, P1248, DOI 10.1074/jbc.M208419200
   Zhao X, 2003, CURR DRUG METAB, V4, P73, DOI 10.2174/1389200033336892
   Zhao XY, 2005, AM J PHYSIOL-REG I, V288, pR188, DOI 10.1152/ajpregu.00018.2004
   Zisman A, 2000, NAT MED, V6, P924, DOI 10.1038/78693
NR 156
TC 33
Z9 35
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1098-8823
EI 2212-196X
J9 PROSTAG OTH LIPID M
JI Prostaglandins Other Lipid Mediat.
PD JAN
PY 2012
VL 97
IS 1-2
BP 1
EP 16
DI 10.1016/j.prostaglandins.2011.10.002
PG 16
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 897MI
UT WOS:000300654400001
PM 22100745
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Islam, MR
   Rauf, A
   Akash, S
   Trisha, SI
   Nasim, AH
   Akter, M
   Dhar, PS
   Ogaly, HA
   Hemeg, HA
   Wilairatana, P
   Thiruvengadam, M
AF Islam, Md. Rezaul
   Rauf, Abdur
   Akash, Shopnil
   Trisha, Sadiya Islam
   Nasim, Akram Hossain
   Akter, Muniya
   Dhar, Puja Sutro
   Ogaly, Hanan A.
   Hemeg, Hassan A.
   Wilairatana, Polrat
   Thiruvengadam, Muthu
TI Targeted therapies of curcumin focus on its therapeutic benefits in
   cancers and human health: Molecular signaling pathway-based approaches
   and future perspectives
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Curcuma longa; Curcumin; Turmeric; Antioxidant; Anti-inflammatory;
   Medicine; Cancer
ID NF-KAPPA-B; HUMAN BREAST-CANCER; CELL-CYCLE ARREST; CHEMOPREVENTIVE
   AGENT CURCUMIN; IN-VITRO; OXIDATIVE STRESS; GENE-EXPRESSION;
   COLON-CANCER; INDUCED APOPTOSIS; IMMUNE-SYSTEM
AB The curry powder spices turmeric (Curcuma longa L.), which contains curcumin (diferuloylmethane), an orangeyellow chemical. Polyphenols are the most commonly used sources of curcumin. It combats oxidative stress and inflammation in diseases, such as hyperlipidemia, metabolic syndrome, arthritis, and depression. Most of these benefits are due to their anti-inflammatory and antioxidant properties. Curcumin consumption leads to decreased bioavailability, resulting in limited absorption, quick metabolism, and quick excretion, which hinders health improvement. Numerous factors can increase its bioavailability. Piperine enhances bioavailability when combined with curcumin in a complex. When combined with other enhancing agents, curcumin has a wide spectrum of health benefits. This review evaluates the therapeutic potential of curcumin with a specific emphasis on its approach based on molecular signaling pathways. This study investigated its influence on the progression of cancer, inflammation, and many health-related mechanisms, such as cell proliferation, apoptosis, and metastasis. Curcumin has a significant potential for the prevention and treatment of various diseases. Curcumin modulates several biochemical pathways and targets involved in cancer growth. Despite its limited tissue accumulation and bioavailability when administered orally, curcumin has proven useful. This review provides an in-depth analysis of curcumin's therapeutic applications, its molecular signaling pathway-based approach, and its potential for precision medicine in cancer and human health.
C1 [Islam, Md. Rezaul; Akash, Shopnil; Trisha, Sadiya Islam; Nasim, Akram Hossain; Akter, Muniya; Dhar, Puja Sutro] Daffodil Int Univ, Fac Allied Hlth Sci, Dept Pharm, Dhaka 1216, Bangladesh.
   [Rauf, Abdur] Univ Swabi, Dept Chem, Anbar 23561, Khyber Pakhtunk, Pakistan.
   [Ogaly, Hanan A.] King Khalid Univ, Coll Sci, Chem Dept, Abha 61421, Saudi Arabia.
   [Hemeg, Hassan A.] Taibah Univ, Coll Appl Med Sci, Dept Med Lab Technol, Al Medinah Al Monawara, Saudi Arabia.
   [Wilairatana, Polrat] Mahidol Univ, Fac Trop Med, Dept Clin Trop Med, Bangkok 10400, Thailand.
   [Thiruvengadam, Muthu] Konkuk Univ, Coll Life & Environm Sci, Dept Appl Biosci, Seoul 05029, South Korea.
   [Thiruvengadam, Muthu] Saveetha Univ, Saveetha Inst Med & Tech Sci SIMATS, Saveetha Dent Coll & Hosp, Dept Microbiol, Chennai 600077, India.
C3 Daffodil International University; King Khalid University; Taibah
   University; Mahidol University; Konkuk University; Saveetha Institute of
   Medical & Technical Science; Saveetha Dental College & Hospital
RP Rauf, A (corresponding author), Univ Swabi, Dept Chem, Anbar 23561, Khyber Pakhtunk, Pakistan.; Wilairatana, P (corresponding author), Mahidol Univ, Fac Trop Med, Dept Clin Trop Med, Bangkok 10400, Thailand.; Thiruvengadam, M (corresponding author), Konkuk Univ, Coll Life & Environm Sci, Dept Appl Biosci, Seoul 05029, South Korea.
EM mashaljcs@yahoo.com; polrat.wil@mahidol.ac.th; muthu@konkuk.ac.kr
RI Ogaly, Hanan/ACA-5011-2022; Islam, Md. Rezaul/ABC-5725-2021;
   Thiruvengadam, Muthu/AAP-8023-2021; Rauf, Abdur/G-3304-2013
FU Deanship of Scientific Research at King Khalid University [RGP2/93/44]
FX Deanship of Scientific Research at King Khalid University for funding
   this work through large group Research Project under grant number
   RGP2/93/44.
CR Adak A, 2019, CELL MOL LIFE SCI, V76, P473, DOI 10.1007/s00018-018-2943-4
   Aggarwal BB, 2005, CLIN CANCER RES, V11, P7490, DOI 10.1158/1078-0432.CCR-05-1192
   Aggarwal BB, 2003, ANTICANCER RES, V23, P363
   Aggarwal BB, 2008, CANCER BIOL THER, V7, P1438, DOI 10.4161/cbt.7.9.6659
   Aggarwal BB, 2006, BIOCHEM PHARMACOL, V72, P1605, DOI 10.1016/j.bcp.2006.06.029
   Aggarwal BB, 2009, CURR OPIN PHARMACOL, V9, P351, DOI 10.1016/j.coph.2009.06.020
   Aggarwal BB, 2009, TRENDS PHARMACOL SCI, V30, P85, DOI 10.1016/j.tips.2008.11.002
   Aggarwal BB, 2009, INT J BIOCHEM CELL B, V41, P40, DOI 10.1016/j.biocel.2008.06.010
   Aggarwal S, 2004, INT J CANCER, V111, P679, DOI 10.1002/ijc.20333
   Alizadeh M, 2019, BIOMEDICINE-TAIWAN, V9, P10, DOI 10.1051/bmdcn/2019090423
   Allegri P, 2010, CLIN OPHTHALMOL, V4, P1201, DOI 10.2147/OPTH.S13271
   Alonso-Fernandez Patricia, 2011, Curr Aging Sci, V4, P78
   AMMON HPT, 1993, J ETHNOPHARMACOL, V38, P113, DOI 10.1016/0378-8741(93)90005-P
   Anand P, 2008, CANCER LETT, V267, P133, DOI 10.1016/j.canlet.2008.03.025
   Anand P, 2007, MOL PHARMACEUT, V4, P807, DOI 10.1021/mp700113r
   Aoki H, 2007, MOL PHARMACOL, V72, P29, DOI 10.1124/mol.106.033167
   Aristotle L, 2004, ANTICANCER RES, V24, P987
   ARORA RB, 1971, INDIAN J MED RES, V59, P1289
   Asai A, 2000, LIFE SCI, V67, P2785, DOI 10.1016/S0024-3205(00)00868-7
   Asbaghi O, 2022, CRIT REV FOOD SCI, V62, P8435, DOI 10.1080/10408398.2021.1928598
   Ashrafizadeh M, 2020, PHARMACOL RES, V160, DOI 10.1016/j.phrs.2020.105199
   Aslanabadi N, 2019, EUR J PHARMACOL, V858, DOI 10.1016/j.ejphar.2019.172471
   Attia YM, 2020, CHEM-BIOL INTERACT, V315, DOI 10.1016/j.cbi.2019.108865
   Avci G, 2012, J SURG RES, V172, pE39, DOI 10.1016/j.jss.2011.08.021
   Awasthi H, 2010, LIFE SCI, V86, P87, DOI 10.1016/j.lfs.2009.11.007
   Azami SH, 2020, REPROD FERT DEVELOP, V32, P292, DOI 10.1071/RD18472
   Bachmeier BE, 2008, CARCINOGENESIS, V29, P779, DOI 10.1093/carcin/bgm248
   Bäckhed F, 2005, SCIENCE, V307, P1915, DOI 10.1126/science.1104816
   Banerjee Saswati, 2017, Front Biosci (Elite Ed), V9, P235
   Barnes RP, 2019, MECH AGEING DEV, V177, P37, DOI 10.1016/j.mad.2018.03.013
   Bengmark S, 2006, JPEN-PARENTER ENTER, V30, P45, DOI 10.1177/014860710603000145
   Berrak Ö, 2016, BIOMED PHARMACOTHER, V77, P150, DOI 10.1016/j.biopha.2015.12.007
   Bessard A, 2009, MOL CANCER THER, V8, P2736, DOI 10.1158/1535-7163.MCT-09-0275
   Bielenberg DR, 2015, CANCER J, V21, P267, DOI 10.1097/PPO.0000000000000138
   Bimonte S, 2016, NUTRIENTS, V8, DOI 10.3390/nu8070433
   Bray F, 2018, CA-CANCER J CLIN, V68, P394, DOI [10.3322/caac.21492, 10.3322/caac.21609]
   Bright JJ, 2007, ADV EXP MED BIOL, V595, P425
   Cai T, 2009, INT J ANTIMICROB AG, V33, P549, DOI 10.1016/j.ijantimicag.2008.11.012
   Campbell Frederick C, 2005, Future Oncol, V1, P405, DOI 10.1517/14796694.1.3.405
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2018, GUT, V67, P1716, DOI 10.1136/gutjnl-2018-316723
   Cannizzo ES, 2011, J PROTEOMICS, V74, P2313, DOI 10.1016/j.jprot.2011.06.005
   Cardinali DP, 2008, NEUROIMMUNOMODULAT, V15, P272, DOI 10.1159/000156470
   Chainoglou E, 2019, EXPERT OPIN DRUG DIS, V14, P821, DOI 10.1080/17460441.2019.1614560
   Chan MMY, 1998, BIOCHEM PHARMACOL, V55, P1955, DOI 10.1016/S0006-2952(98)00114-2
   CHAN MMY, 1995, CANCER LETT, V96, P23, DOI 10.1016/0304-3835(95)03913-H
   Chan WH, 2005, ANN NY ACAD SCI, V1042, P372, DOI 10.1196/annals.1338.057
   CHANDRA D, 1972, INDIAN J MED RES, V60, P138
   Chandra RK, 1997, AM J CLIN NUTR, V66, P460
   Chang DZ, 2012, J HEMATOL ONCOL, V5, DOI 10.1186/1756-8722-5-15
   Chauhan DP, 2002, CURR PHARM DESIGN, V8, P1695, DOI 10.2174/1381612023394016
   Chen A, 2006, ONCOGENE, V25, P278, DOI [10.1038/sj.onc.1209019, 10.1038/sj.onc.1209573]
   Chen AP, 2005, AM J PHYSIOL-GASTR L, V288, pG447, DOI 10.1152/ajpgi.00209.2004
   Chen YM, 2020, FOOD FUNCT, V11, P3574, DOI [10.1039/C9FO02487E, 10.1039/c9fo02487e]
   Chen YR, 1998, ONCOGENE, V17, P173, DOI 10.1038/sj.onc.1201941
   Cheng KK, 2015, BIOMATERIALS, V44, P155, DOI 10.1016/j.biomaterials.2014.12.005
   Chilelli NC, 2016, NUTRIENTS, V8, DOI 10.3390/nu8110745
   Choudhuri T, 2002, FEBS LETT, V512, P334, DOI 10.1016/S0014-5793(02)02292-5
   Choudhuri T, 2005, J BIOL CHEM, V280, P20059, DOI 10.1074/jbc.M410670200
   Chuengsamarn S, 2012, DIABETES CARE, V35, P2121, DOI 10.2337/dc12-0116
   Cianfruglia L, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8090382
   Coker-Gurkan A, 2018, AMINO ACIDS, V50, P1045, DOI 10.1007/s00726-018-2581-z
   Cole G. M., 2003, Current Medicinal Chemistry - Immunology Endocrine & Metabolic Agents, V3, P15, DOI 10.2174/1568013033358761
   CONNEY AH, 1991, ADV ENZYME REGUL, V31, P385, DOI 10.1016/0065-2571(91)90025-H
   Cox KHM, 2015, J PSYCHOPHARMACOL, V29, P642, DOI 10.1177/0269881114552744
   Crispi S., 2019, Vitr. Vivo Anal., J. Exp. Clin. Cancer Res, V38, P1
   Culley L, 2013, HUM REPROD UPDATE, V19, P625, DOI 10.1093/humupd/dmt027
   Damiani E, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/5469159
   Das L, 2018, ANTI-CANCER AGENT ME, V18, P1779, DOI 10.2174/1871520618666180604093802
   Davis T, 2005, BIOGERONTOLOGY, V6, P371, DOI 10.1007/s10522-005-4901-4
   Decaestecker C, 2007, MED RES REV, V27, P149, DOI 10.1002/med.20078
   Deepak KGK, 2020, PHARMACOL RES, V153, DOI 10.1016/j.phrs.2020.104683
   Delecroix B, 2017, J SPORT SCI MED, V16, P147
   Delves PJ, 2000, NEW ENGL J MED, V343, P37, DOI 10.1056/NEJM200007063430107
   Dempe JS, 2013, MOL NUTR FOOD RES, V57, P1543, DOI 10.1002/mnfr.201200113
   Dey A, 2008, NAT REV DRUG DISCOV, V7, P1031, DOI 10.1038/nrd2759
   Dhillon N, 2008, CLIN CANCER RES, V14, P4491, DOI 10.1158/1078-0432.CCR-08-0024
   Di Meo F, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102426
   DiSilvestro RA, 2012, NUTR J, V11, DOI 10.1186/1475-2891-11-79
   Dorai T, 2001, PROSTATE, V47, P293, DOI 10.1002/pros.1074
   Dou YN, 2018, J NEUROINFLAMM, V15, DOI 10.1186/s12974-017-1047-7
   Drobnic F, 2014, J INT SOC SPORT NUTR, V11, DOI 10.1186/1550-2783-11-31
   Duan WX, 2014, MOL MED REP, V10, P2505, DOI 10.3892/mmr.2014.2551
   Duvoix A, 2005, CANCER LETT, V223, P181, DOI 10.1016/j.canlet.2004.09.041
   Eghbaliferiz S, 2020, PHARMACOL REP, V72, P769, DOI 10.1007/s43440-020-00112-3
   Elmansi AM, 2017, ANN HEPATOL, V16, P607, DOI 10.5604/01.3001.0010.0307
   ENGVALL E, 1971, IMMUNOCHEMISTRY, V8, P871, DOI 10.1016/0019-2791(71)90454-X
   Epelbaum R, 2010, NUTR CANCER, V62, P1137, DOI 10.1080/01635581.2010.513802
   Epstein J, 2010, BRIT J NUTR, V103, P1545, DOI 10.1017/S0007114509993667
   Esatbeyoglu T, 2012, ANGEW CHEM INT EDIT, V51, P5308, DOI 10.1002/anie.201107724
   Esmaily H, 2015, CHIN J INTEGR MED, V21, P332, DOI 10.1007/s11655-015-2160-z
   Faralli A, 2019, CARBOHYD POLYM, V206, P38, DOI 10.1016/j.carbpol.2018.10.073
   Feng WH, 2017, BBA-GEN SUBJECTS, V1861, P1801, DOI 10.1016/j.bbagen.2017.03.017
   Fouani L, 2017, PHARMACOL RES, V115, P275, DOI 10.1016/j.phrs.2016.12.001
   Franceschi C, 2000, ANN NY ACAD SCI, V908, P244
   Frautschy SA, 2001, NEUROBIOL AGING, V22, P993, DOI 10.1016/S0197-4580(01)00300-1
   Fu YH, 2014, INT IMMUNOPHARMACOL, V20, P54, DOI 10.1016/j.intimp.2014.01.024
   Gavrilas LI, 2019, FOOD FUNCT, V10, P3717, DOI [10.1039/c9fo01014a, 10.1039/C9FO01014A]
   Gee VMW, 2014, J COMPUT AID MOL DES, V28, P1143, DOI 10.1007/s10822-014-9791-6
   Geurts L, 2011, FRONT MICROBIOL, V2, DOI 10.3389/fmicb.2011.00149
   Ghasemi F, 2019, PATHOL RES PRACT, V215, DOI 10.1016/j.prp.2019.152556
   GHATAK N, 1972, INDIAN J EXP BIOL, V10, P235
   Ghosh SS, 2018, TISSUE BARRIERS, V6, DOI 10.1080/21688370.2018.1425085
   Ghosh SS, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0108577
   Gonzalez-Hunt Claudia P., 2018, Current Opinion in Toxicology, V7, P87, DOI 10.1016/j.cotox.2017.11.001
   González-Reyes S, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/801418
   Gruver AL, 2007, J PATHOL, V211, P144, DOI 10.1002/path.2104
   Guo SH, 2013, AM J PATHOL, V182, P375, DOI 10.1016/j.ajpath.2012.10.014
   Gupta SC, 2013, MOL NUTR FOOD RES, V57, P1510, DOI 10.1002/mnfr.201100741
   Gupta SC, 2013, AAPS J, V15, P195, DOI 10.1208/s12248-012-9432-8
   Gupta SC, 2011, NAT PROD REP, V28, P1937, DOI 10.1039/c1np00051a
   Halliwell B., 2015, Free Radicals in Biology and Medicine
   Han HK, 2011, EXPERT OPIN DRUG MET, V7, P721, DOI 10.1517/17425255.2011.570332
   Hatcher H, 2008, CELL MOL LIFE SCI, V65, P1631, DOI 10.1007/s00018-008-7452-4
   He ZY, 2011, CANCER INVEST, V29, P208, DOI 10.3109/07357907.2010.550592
   Hewlings SJ, 2017, FOODS, V6, DOI 10.3390/foods6100092
   HOLDER GM, 1978, XENOBIOTICA, V8, P761, DOI 10.3109/00498257809069589
   Howells LM, 2007, INT J CANCER, V121, P175, DOI 10.1002/ijc.22645
   Hu MW, 2005, CRIT CARE MED, V33, P2571, DOI 10.1097/01.CCM.0000186760.20502.C7
   Ide H, 2018, CANCER SCI, V109, P1230, DOI 10.1111/cas.13517
   Imam Z, 2019, CASE REP GASTROINTES, V2019, DOI 10.1155/2019/6029403
   Iqbal B, 2018, J CANCER RES THER, V14, pS1193, DOI 10.4103/jcrt.JCRT_348_18
   Ireson C, 2001, CANCER RES, V61, P1058
   Ireson CR, 2002, CANCER EPIDEM BIOMAR, V11, P105
   Irving GRB, 2015, TRIALS, V16, DOI 10.1186/s13063-015-0641-1
   Islam T, 2021, MOL NUTR FOOD RES, V65, DOI 10.1002/mnfr.202100274
   Jacob J.N., 2013, Nat. Prod. Commun., V8
   Jain A, 2015, CANCER LETT, V365, P122, DOI 10.1016/j.canlet.2015.05.017
   Jana S, 2012, BIOCHEM PHARMACOL, V83, P797, DOI 10.1016/j.bcp.2011.12.030
   Jee SH, 1998, J INVEST DERMATOL, V111, P656, DOI 10.1046/j.1523-1747.1998.00352.x
   Jiao Y, 2009, BLOOD, V113, P462, DOI 10.1182/blood-2008-05-155952
   Jobin C, 1999, J IMMUNOL, V163, P3474
   Jurenka JS, 2009, ALTERN MED REV, V14, P141
   Kamal DAM, 2021, NUTRIENTS, V13, DOI 10.3390/nu13093126
   Kanai M, 2014, WORLD J GASTROENTERO, V20, P9384, DOI 10.3748/wjg.v20.i28.9384
   Kato K, 1998, CELL STRESS CHAPERON, V3, P152, DOI 10.1379/1466-1268(1998)003<0152:SOTSIE>2.3.CO;2
   Kato M, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600471
   Kawanishi S, 2004, ANN NY ACAD SCI, V1019, P278, DOI 10.1196/annals.1297.047
   Khan MA, 2012, MOL CANCER THER, V11, P1873, DOI 10.1158/1535-7163.MCT-12-0141
   Kianvash N, 2017, DRUG DELIV TRANSL RE, V7, P654, DOI 10.1007/s13346-017-0405-4
   Kim GY, 2005, J IMMUNOL, V174, P8116, DOI 10.4049/jimmunol.174.12.8116
   Kim JM, 1998, CARCINOGENESIS, V19, P81, DOI 10.1093/carcin/19.1.81
   Kim K, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/7125162
   Kocaadam B, 2017, CRIT REV FOOD SCI, V57, P2889, DOI 10.1080/10408398.2015.1077195
   Kohli K., 2005, Indian Journal of Pharmacology, V37, P141
   Kumar A, 2010, CRIT REV THER DRUG, V27, P279, DOI 10.1615/CritRevTherDrugCarrierSyst.v27.i4.10
   Kumar PA, 2005, ARCH BIOCHEM BIOPHYS, V444, P77, DOI 10.1016/j.abb.2005.09.021
   Kumar PA, 2005, MOL VIS, V11, P561
   Kuptniratsaikul V, 2014, CLIN INTERV AGING, V9, P451, DOI 10.2147/CIA.S58535
   Lamb SR, 2003, CONTACT DERMATITIS, V48, P227, DOI 10.1034/j.1600-0536.2003.00062.x
   Lao Christopher D, 2006, BMC Complement Altern Med, V6, P10, DOI 10.1186/1472-6882-6-10
   Lee Sylvia, 2011, Cancers (Basel), V3, P3856, DOI 10.3390/cancers3043856
   Lee YJ, 2011, KOREAN J PHYSIOL PHA, V15, P1, DOI 10.4196/kjpp.2011.15.1.1
   Lee YH, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20112716
   Lestari Maria L A D, 2014, Profiles Drug Subst Excip Relat Methodol, V39, P113, DOI 10.1016/B978-0-12-800173-8.00003-9
   Leu Tzeng-Horng, 2002, Current Medicinal Chemistry - Anti-Cancer Agents, V2, P357, DOI 10.2174/1568011024606370
   Lev-Ari S, 2006, ANTICANCER RES, V26, P4423
   Lheureux S, 2017, EUR J NUCL MED MOL I, V44, pS41, DOI 10.1007/s00259-017-3695-3
   Li M, 2007, CANCER RES, V67, P1988, DOI 10.1158/0008-5472.CAN-06-3066
   Lin CC, 2019, NUTRIENTS, V11, DOI 10.3390/nu11030700
   Lin YG, 2007, CLIN CANCER RES, V13, P3423, DOI 10.1158/1078-0432.CCR-06-3072
   Liu AC, 2013, PLANTA MED, V79, P971, DOI 10.1055/s-0032-1328652
   Liu DW, 2013, J BREAST CANCER, V16, P133, DOI 10.4048/jbc.2013.16.2.133
   Liu SY, 2022, MOLECULES, V27, DOI 10.3390/molecules27144400
   Liu WD, 2016, J DRUG TARGET, V24, P694, DOI 10.3109/1061186X.2016.1157883
   Liu Y, 2015, EUR REV MED PHARMACO, V19, P1736
   LoTempio MM, 2005, CLIN CANCER RES, V11, P6994, DOI 10.1158/1078-0432.CCR-05-0301
   Lou Y, 2015, J CHROMATOGR B, V985, P38, DOI 10.1016/j.jchromb.2015.01.014
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   Lozupone CA, 2012, NATURE, V489, P220, DOI 10.1038/nature11550
   Lu WS, 2013, EXP CELL RES, V319, P133, DOI 10.1016/j.yexcr.2012.09.005
   Luca SV, 2020, CRIT REV FOOD SCI, V60, P626, DOI 10.1080/10408398.2018.1546669
   Luo XL, 2020, PHARMACOL RES, V156, DOI 10.1016/j.phrs.2020.104805
   Mahady GB, 2002, ANTICANCER RES, V22, P4179
   Maheshwari RK, 2006, LIFE SCI, V78, P2081, DOI 10.1016/j.lfs.2005.12.007
   MANGELSDORF DJ, 1995, CELL, V83, P835, DOI 10.1016/0092-8674(95)90199-X
   Manikandan R, 2011, MOL VIS, V17, P388
   Mansuri ML, 2014, GENES NUTR, V9, DOI 10.1007/s12263-014-0400-z
   Mantzorou M, 2018, PHYTOTHER RES, V32, P957, DOI 10.1002/ptr.6037
   Marchiani A, 2014, CURR MED CHEM, V21, P204
   Marczylo TH, 2009, J AGR FOOD CHEM, V57, P797, DOI 10.1021/jf803038f
   Masamune A, 2006, J CELL BIOCHEM, V97, P1080, DOI 10.1002/jcb.20698
   Masoodi M, 2018, J CELL BIOCHEM, V119, P9552, DOI 10.1002/jcb.27273
   Mazzolani F, 2013, CLIN OPHTHALMOL, V7, P939, DOI 10.2147/OPTH.S45820
   McFadden RMT, 2015, INFLAMM BOWEL DIS, V21, P2483, DOI 10.1097/MIB.0000000000000522
   McFarlin BK, 2016, BBA CLIN, V5, P72, DOI 10.1016/j.bbacli.2016.02.003
   Medzhitov R, 2008, NATURE, V454, P428, DOI 10.1038/nature07201
   Medzhitov R, 2010, CELL, V140, P771, DOI 10.1016/j.cell.2010.03.006
   Menon LG, 1999, CANCER LETT, V141, P159, DOI 10.1016/S0304-3835(99)00098-1
   Menon VP, 2007, ADV EXP MED BIOL, V595, P105
   Metzler M, 2013, BIOFACTORS, V39, P14, DOI 10.1002/biof.1042
   Mohamed SIA, 2017, INT IMMUNOPHARMACOL, V50, P291, DOI 10.1016/j.intimp.2017.07.010
   Mohebbati R, 2017, Endocr Regul, V51, P220, DOI 10.1515/enr-2017-0024
   Mohseni M, 2021, PHYTOTHER RES, V35, P6862, DOI 10.1002/ptr.7273
   Moore TL, 2018, SOMATOSENS MOT RES, V35, P1, DOI 10.1080/08990220.2018.1432481
   Moorthi C., 2012, Asian Pacific Journal of Tropical Biomedicine, V2, P841, DOI 10.1016/S2221-1691(12)60241-X
   Motterlini R, 2000, FREE RADICAL BIO MED, V28, P1303, DOI 10.1016/S0891-5849(00)00294-X
   Muegge BD, 2011, SCIENCE, V332, P970, DOI 10.1126/science.1198719
   MUKHOPADHYAY A, 1982, AGENTS ACTIONS, V12, P508, DOI 10.1007/BF01965935
   Murakami A, 2013, BIOFACTORS, V39, P221, DOI 10.1002/biof.1054
   Murugan Pidaran, 2006, Journal of Basic and Clinical Physiology and Pharmacology, V17, P231
   Na LX, 2011, NUTR METAB CARDIOVAS, V21, P526, DOI 10.1016/j.numecd.2009.11.009
   Nabavi SF, 2014, COMPR REV FOOD SCI F, V13, P62, DOI 10.1111/1541-4337.12047
   Nagaraju GP, 2012, INTEGR BIOL-UK, V4, P996, DOI 10.1039/c2ib20088k
   Nagpal Monika, 2013, J Nat Sci Biol Med, V4, P3, DOI 10.4103/0976-9668.107253
   Naito Michitaka, 2002, J Atheroscler Thromb, V9, P243
   Nakagawa Y, 2014, J ORTHOP SCI, V19, P933, DOI 10.1007/s00776-014-0633-0
   Nakamae I, 2019, MOLECULES, V24, DOI 10.3390/molecules24224067
   Nasef NA, 2019, FOOD FUNCT, V10, P4584, DOI [10.1039/C9FO01063G, 10.1039/c9fo01063g]
   Negrini S, 2010, NAT REV MOL CELL BIO, V11, P220, DOI 10.1038/nrm2858
   Ngoma T, 2006, ANN ONCOL, V17, P9, DOI [10.1093/annonc/mdl982, 10.1093/annonc.mdl983]
   Nouri-Vaskeh M, 2020, PHYTOTHER RES, V34, P1446, DOI 10.1002/ptr.6620
   Oettle H, 2014, CANCER TREAT REV, V40, P1039, DOI 10.1016/j.ctrv.2014.07.003
   Ohno M, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0185999
   Okada K, 2001, J NUTR, V131, P2090, DOI 10.1093/jn/131.8.2090
   Olovnikov AM, 1996, EXP GERONTOL, V31, P443, DOI 10.1016/0531-5565(96)00005-8
   Osterman CJD, 2016, PANCREAS, V45, P101, DOI 10.1097/MPA.0000000000000411
   Oyama Y, 1998, EUR J PHARMACOL, V360, P65, DOI 10.1016/S0014-2999(98)00635-9
   Pal S, 2005, CANCER DETECT PREV, V29, P470, DOI 10.1016/j.cdp.2005.05.003
   Pal S, 2001, BIOCHEM BIOPH RES CO, V288, P658, DOI 10.1006/bbrc.2001.5823
   Pan MH, 1999, DRUG METAB DISPOS, V27, P486
   Panahi Y, 2016, BIOMED PHARMACOTHER, V82, P578, DOI 10.1016/j.biopha.2016.05.037
   Panahi Y, 2014, J FUNCT FOODS, V6, P615, DOI 10.1016/j.jff.2013.12.008
   Parikh A, 2018, DRUG DELIV TRANSL RE, V8, P1406, DOI 10.1007/s13346-018-0570-0
   Park S, 2016, GENES NUTR, V11, DOI 10.1186/s12263-016-0520-4
   Pavithra BH, 2009, J VET SCI, V10, P293, DOI 10.4142/jvs.2009.10.4.293
   Perrone D, 2015, EXP THER MED, V10, P1615, DOI 10.3892/etm.2015.2749
   Pfeiffer E, 2007, J AGR FOOD CHEM, V55, P538, DOI 10.1021/jf0623283
   Piper JT, 1998, INT J BIOCHEM CELL B, V30, P445, DOI 10.1016/S1357-2725(98)00015-6
   Pradhan AK, 2020, CANCER METAST REV, V39, P769, DOI 10.1007/s10555-020-09886-7
   Prakobwong S, 2011, INT J CANCER, V129, P88, DOI 10.1002/ijc.25656
   Prasad S, 2014, CANCER RES TREAT, V46, P2, DOI 10.4143/crt.2014.46.1.2
   Pricci M, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21072364
   Priyadarsini KI, 2014, MOLECULES, V19, P20091, DOI 10.3390/molecules191220091
   Priyadarsini KI, 2003, FREE RADICAL BIO MED, V35, P475, DOI 10.1016/S0891-5849(03)00325-3
   Ramachandran C, 2002, CANCER LETT, V184, P1, DOI 10.1016/S0304-3835(02)00192-1
   Ramachandran L, 2012, J BIOL CHEM, V287, DOI 10.1074/jbc.M112.388702
   RamirezBosca A, 1995, AGE, V18, P167, DOI 10.1007/BF02432631
   Rashmi R, 2003, FEBS LETT, V538, P19, DOI 10.1016/S0014-5793(03)00099-1
   Rates SMK, 2001, TOXICON, V39, P603, DOI 10.1016/S0041-0101(00)00154-9
   Recio MC, 2012, CURR MED CHEM, V19, P2088
   Reddy RC, 2005, BIOCHEM BIOPH RES CO, V326, P472, DOI 10.1016/j.bbrc.2004.11.051
   REDDY S, 1994, FEBS LETT, V341, P19, DOI 10.1016/0014-5793(94)80232-7
   Reddy S, 2006, NUTR CANCER, V55, P185, DOI 10.1207/s15327914nc5502_10
   Reuter S, 2011, GENES NUTR, V6, P93, DOI 10.1007/s12263-011-0222-1
   Rushworth SA, 2006, BIOCHEM BIOPH RES CO, V341, P1007, DOI 10.1016/j.bbrc.2006.01.065
   Sahebkar A, 2015, J FUNCT FOODS, V18, P898, DOI 10.1016/j.jff.2015.01.005
   Salh B, 2003, AM J PHYSIOL-GASTR L, V285, pG235, DOI 10.1152/ajpgi.00449.2002
   Sandur SK, 2007, FREE RADICAL BIO MED, V43, P568, DOI 10.1016/j.freeradbiomed.2007.05.009
   Sandur SK, 2007, CARCINOGENESIS, V28, P1765, DOI 10.1093/carcin/bgm123
   Santos-Parker Jessica R, 2018, Nutr Healthy Aging, V4, P323, DOI 10.3233/NHA-170029
   Sarraf P, 1998, NAT MED, V4, P1046, DOI 10.1038/2030
   Sathyapalan T, 2011, MINERVA ENDOCRINOL, V36, P147
   Saw CLL, 2010, BIOCHEM PHARMACOL, V79, P421, DOI 10.1016/j.bcp.2009.08.030
   SEGER R, 1995, FASEB J, V9, P726, DOI 10.1096/fasebj.9.9.7601337
   Sethi G, 2012, BIOSCIENCE REP, V32, P1, DOI 10.1042/BSR20100136
   Sethi G, 2009, TRENDS PHARMACOL SCI, V30, P313, DOI 10.1016/j.tips.2009.03.004
   Shafabakhsh R, 2019, PHARMACOL RES, V147, DOI 10.1016/j.phrs.2019.104353
   Shaikh J, 2009, EUR J PHARM SCI, V37, P223, DOI 10.1016/j.ejps.2009.02.019
   Shankar S, 2007, INT J ONCOL, V30, P905
   Sharma RA, 2001, CLIN CANCER RES, V7, P1894
   Sharma RA, 2004, CLIN CANCER RES, V10, P6847, DOI 10.1158/1078-0432.CCR-04-0744
   Sharma RA, 2005, EUR J CANCER, V41, P1955, DOI 10.1016/j.ejca.2005.05.009
   Shehzad A, 2010, ARCH PHARM, V343, P489, DOI 10.1002/ardp.200900319
   Shi LY, 2018, PHARMACOL REP, V70, P1040, DOI 10.1016/j.pharep.2018.05.006
   Shi L, 2015, TUMOR BIOL, V36, P7107, DOI 10.1007/s13277-015-3427-x
   Shi MX, 2006, CELL BIOL INT, V30, P221, DOI 10.1016/j.cellbi.2005.10.024
   Shishodia S, 2005, BIOCHEM PHARMACOL, V70, P700, DOI 10.1016/j.bcp.2005.04.043
   Shishodia S, 2007, CURR PROB CANCER, V31, P243, DOI 10.1016/j.currproblcancer.2007.04.001
   Shoba G, 1998, PLANTA MED, V64, P353, DOI 10.1055/s-2006-957450
   Siddiqui FA, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-25524-3
   Sidhu Gurmel S., 1998, Wound Repair and Regeneration, V6, P167, DOI 10.1046/j.1524-475X.1998.60211.x
   Sikka S, 2012, PPAR RES, V2012, DOI 10.1155/2012/968040
   Singh L, 2021, MOLECULES, V26, DOI 10.3390/molecules26134036
   Sirisidthi Kanjana, 2016, Indian Journal of Agricultural Research, V50, P101, DOI 10.18805/ijare.v50i2.9586
   Sivanantham B, 2016, ACS COMB SCI, V18, P22, DOI 10.1021/acscombsci.5b00043
   Song G, 2005, BRAZ J MED BIOL RES, V38, P1791, DOI 10.1590/S0100-879X2005001200007
   SRIMAL RC, 1973, J PHARM PHARMACOL, V25, P447, DOI 10.1111/j.2042-7158.1973.tb09131.x
   Srinivasan M, 1972, Indian J Med Sci, V26, P269
   Srivastava RK, 2007, CELL CYCLE, V6, P2953, DOI 10.4161/cc.6.23.4951
   STELL PM, 1989, EUR J SURG ONCOL, V15, P407
   Strimpakos AS, 2008, ANTIOXID REDOX SIGN, V10, P511, DOI 10.1089/ars.2007.1769
   Sugimoto K, 2002, GASTROENTEROLOGY, V123, P1912, DOI 10.1053/gast.2002.37050
   Sugiyama Y, 1996, BIOCHEM PHARMACOL, V52, P519, DOI 10.1016/0006-2952(96)00302-4
   Surh YJ, 2001, MUTAT RES-FUND MOL M, V480, P243, DOI 10.1016/S0027-5107(01)00183-X
   Tamvakopoulos C, 2007, EUR J DRUG METAB PH, V32, P51, DOI 10.1007/BF03190990
   Tavakol S, 2019, DARU, V27, P159, DOI 10.1007/s40199-019-00258-3
   Tergaonkar V, 2009, CELL RES, V19, P1313, DOI 10.1038/cr.2009.132
   Thangapazham RL, 2006, AAPS J, V8, pE443, DOI 10.1208/aapsj080352
   Tian XP, 2010, APPL BIOCHEM BIOTECH, V160, P1460, DOI 10.1007/s12010-009-8633-9
   TODA S, 1985, CHEM PHARM BULL, V33, P1725
   Tomeh MA, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20051033
   Tong WH, 2016, ONCOL LETT, V12, P4139, DOI 10.3892/ol.2016.5148
   Tourkina E, 2004, AM J RESP CELL MOL, V31, P28, DOI 10.1165/rcmb.2003-0354OC
   Trujillo J, 2013, REDOX BIOL, V1, P448, DOI 10.1016/j.redox.2013.09.003
   Tsuda T, 2018, FOOD FUNCT, V9, P705, DOI [10.1039/c7fo01242j, 10.1039/C7FO01242J]
   Tsuiji K, 2011, GYNECOL ENDOCRINOL, V27, P512, DOI 10.3109/09513590.2010.507287
   Van Houten Bennett, 2018, Current Opinion in Toxicology, V7, P9, DOI 10.1016/j.cotox.2017.10.009
   Vandita K, 2012, MOL PHARMACEUT, V9, P3411, DOI 10.1021/mp300209k
   Vera-Ramirez L, 2013, BIOFACTORS, V39, P88, DOI 10.1002/biof.1057
   Von Zglinicki T, 2000, FREE RADICAL BIO MED, V28, P64, DOI 10.1016/S0891-5849(99)00207-5
   W.H. Organization P.H.Ao Canada C.P.H.Ao Canada, 2005, Preventing chronic diseases: a vital investment
   Wang LX, 2015, PHARMACOL THERAPEUT, V151, P141, DOI 10.1016/j.pharmthera.2015.04.002
   Wang YJ, 1997, J PHARMACEUT BIOMED, V15, P1867, DOI 10.1016/S0731-7085(96)02024-9
   Watson PA, 2015, NAT REV CANCER, V15, P701, DOI 10.1038/nrc4016
   Weir NM, 2007, CANCER BIOL THER, V6, P178, DOI 10.4161/cbt.6.2.3577
   Wilken R, 2011, MOL CANCER, V10, DOI 10.1186/1476-4598-10-12
   Wongcharoen W, 2009, INT J CARDIOL, V133, P145, DOI 10.1016/j.ijcard.2009.01.073
   Wright LE, 2013, CURR PHARM DESIGN, V19, P6218, DOI 10.2174/1381612811319340013
   Wu JJ, 2014, INT J ONCOL, V45, P95, DOI 10.3892/ijo.2014.2420
   Yoon H, 2007, J AGR FOOD CHEM, V55, P3167, DOI 10.1021/jf0632379
   Yue GGL, 2010, FOOD CHEM TOXICOL, V48, P2011, DOI 10.1016/j.fct.2010.04.039
   Zaidi S.N.F., 2020, J. Pharm. Sci., V33
   Zhang F, 2014, J CELL MOL MED, V18, P1392, DOI 10.1111/jcmm.12286
   Zhang Y, 2017, NUTRIENTS, V9, DOI 10.3390/nu9020109
   Zhao WL, 2018, J BIOCHEM MOL TOXIC, V32, DOI 10.1002/jbt.22049
   Zheng MZ, 2004, MELANOMA RES, V14, P165, DOI 10.1097/01.cmr.0000129374.76399.19
   Zhu HT, 2014, J NEUROINFLAMM, V11, DOI 10.1186/1742-2094-11-59
   Zou Jiao, 2018, Oncotarget, V9, P11268, DOI 10.18632/oncotarget.24109
NR 319
TC 44
Z9 44
U1 7
U2 23
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JAN
PY 2024
VL 170
AR 116034
DI 10.1016/j.biopha.2023.116034
EA DEC 2023
PG 20
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA FD8W9
UT WOS:001143925000001
PM 38141282
OA gold
DA 2025-06-11
ER

PT J
AU Ghavipour, M
   Saedisomeolia, A
   Djalali, M
   Sotoudeh, G
   Eshraghyan, MR
   Moghadam, AM
   Wood, LG
AF Ghavipour, Mahsa
   Saedisomeolia, Ahmad
   Djalali, Mahmoud
   Sotoudeh, Giti
   Eshraghyan, Mohammad Reza
   Moghadam, Ali Malekshahi
   Wood, Lisa G.
TI Tomato juice consumption reduces systemic inflammation in overweight and
   obese females
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Tomato juice; Carotenoids; Lycopene; Inflammatory biomarkers; Obesity
ID FACTOR-KAPPA-B; METABOLIC SYNDROME-X; OXIDATIVE STRESS; PROINFLAMMATORY
   CYTOKINE; HEART-DISEASE; LYCOPENE; EXPRESSION; PROTEIN; MACROPHAGES;
   INHIBITION
AB Tomatoes are the richest source of lycopene, a potent antioxidant. Tomato products improve antioxidant defences and reduce the risk of inflammatory diseases, at least partly, due to the presence of lycopene. Lycopene, as an anti-inflammatory agent, prevents the production of inflammatory cytokines. Obesity is a chronic inflammatory condition in which the increased level of body fat leads to an increase in circulating inflammatory mediators. We hypothesised that the consumption of a lycopene-rich food would reduce inflammation in people who are overweight or obese. A total of 106 overweight or obese female students of the Tehran University of Medical Sciences were enrolled and randomly allocated to an intervention group (n 53) or a control group (n 53) consuming 330 ml/d of tomato juice or water, respectively, for 20 d. At baseline and day 20, serum concentrations of IL-6, IL-8, high-sensitivity C-reactive protein and TNF-alpha were analysed by ELISA and compared between the groups. Serum concentrations of IL-8 and TNF-alpha decreased significantly in the intervention group compared with the control group and with baseline. Subgroup analysis indicated that this effect was confined to subjects who were overweight. Among obese subjects, serum IL-6 concentration was decreased in the intervention group compared with the control group, with no differences in IL-8 and TNF-alpha observed. Tomato juice reduces inflammation in overweight and obese females. Thus, increasing tomato intake may provide a useful approach for reducing the risk of inflammatory diseases such as CVD and diabetes, which are associated with obesity.
C1 [Ghavipour, Mahsa; Saedisomeolia, Ahmad; Djalali, Mahmoud; Sotoudeh, Giti] Univ Tehran Med Sci, Sch Publ Hlth, Dept Biochem & Nutr, Tehran, Iran.
   [Eshraghyan, Mohammad Reza] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol & Stat, Tehran, Iran.
   [Moghadam, Ali Malekshahi] Univ Tehran, Fac Vet Med, Tehran, Iran.
   [Wood, Lisa G.] Univ Newcastle, Sch Biomed Sci & Pharm, Callaghan, NSW 2308, Australia.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; University of Tehran; University of Newcastle
RP Saedisomeolia, A (corresponding author), Univ Tehran Med Sci, Sch Publ Hlth, Dept Biochem & Nutr, Tehran, Iran.
EM a_saedi@tums.ac.ir
RI Wood, Lisa/G-7068-2013; Sotoudeh, Gity/E-3973-2018
OI Wood, Lisa/0000-0002-0941-9225; Sotoudeh, Gity/0000-0001-6541-2581
FU Vice-chancellor for Research of Tehran University of Medical Sciences
   [10492]
FX The authors gratefully acknowledge the students and officials of Kooy
   and Vesal dormitories for their sincere cooperation. The present work
   was supported by the Vice-chancellor for Research of Tehran University
   of Medical Sciences (grant no. 10492), and the authors declare no
   conflict of interests. The authors would like to advise that all authors
   listed have contributed to the work. M. G. recruited the patients and
   collected the samples, performed laboratory tests, analysed the data and
   drafted the manuscript. A. S., G. S. and L. G. W. supervised the
   nutrition science experiments, contributed to the study design and
   reviewed the manuscript. M. D. supervised the biochemical experiments
   and contributed to the writing of the manuscript. M. R. E. contributed
   to the data analysis and the interpretation of results. A. M. M.
   performed laboratory tests and contributed to the writing of the
   manuscript.
CR Bai SK, 2005, EXP MOL MED, V37, P323, DOI 10.1038/emm.2005.42
   Basu A, 2007, EUR J CLIN NUTR, V61, P295, DOI 10.1038/sj.ejcn.1602510
   Bignotto L, 2009, BRIT J NUTR, V102, P126, DOI 10.1017/S0007114508137886
   Blackwell TS, 1997, AM J RESP CELL MOL, V17, P3, DOI 10.1165/ajrcmb.17.1.f132
   Canene-Adams K, 2005, J NUTR, V135, P1226, DOI 10.1093/jn/135.5.1226
   Chaiyasit W, 2005, J AGR FOOD CHEM, V53, P4982, DOI 10.1021/jf0501239
   Cindrova-Davies T, 2007, AM J PATHOL, V170, P1511, DOI 10.2353/ajpath.2007.061035
   Das U N, 2006, J Assoc Physicians India, V54, P637
   Das UN, 2002, NUTRITION, V18, P430, DOI 10.1016/S0899-9007(01)00747-X
   Das UN, 2010, NUTRITION, V26, P459, DOI 10.1016/j.nut.2009.09.020
   Eckel RH, 1997, CIRCULATION, V96, P3248, DOI 10.1161/01.CIR.96.9.3248
   El-Agamey A, 2004, ARCH BIOCHEM BIOPHYS, V430, P37, DOI 10.1016/j.abb.2004.03.007
   Gouranton E, 2011, J NUTR BIOCHEM, V22, P642, DOI 10.1016/j.jnutbio.2010.04.016
   Hazewindus M, 2012, FOOD CHEM, V132, P954, DOI 10.1016/j.foodchem.2011.11.075
   Herzog A, 2004, FASEB J, V18, P272, DOI 10.1096/fj.04-1905fje
   Huang CS, 2007, J NUTR BIOCHEM, V18, P449, DOI 10.1016/j.jnutbio.2006.08.007
   Kim GY, 2004, IMMUNOLOGY, V113, P203, DOI 10.1111/j.1365-2567.2004.01945.x
   Kim J, 2000, J IMMUNOL, V165, P3384, DOI 10.4049/jimmunol.165.6.3384
   Luc G, 2003, ARTERIOSCL THROM VAS, V23, P1255, DOI 10.1161/01.ATV.0000079512.66448.1D
   Maruyama C, 2001, J NUTR SCI VITAMINOL, V47, P213, DOI 10.3177/jnsv.47.213
   Mehta Supriya D, 2007, Curr Infect Dis Rep, V9, P134, DOI 10.1007/s11908-007-0009-0
   Palozza P, 2011, J NUTR BIOCHEM, V22, P259, DOI 10.1016/j.jnutbio.2010.02.003
   Riso P, 2006, J AGR FOOD CHEM, V54, P2563, DOI 10.1021/jf053033c
   Saedisomeolia A, 2009, J NUTR BIOCHEM, V20, P577, DOI 10.1016/j.jnutbio.2008.06.001
   Shi J, 2004, BIOFACTORS, V21, P203, DOI 10.1002/biof.552210141
   Walfish Y, 2000, BR J NUTR, V90, P759
   Wang Y, 2010, INT J CANCER, V126, P1788, DOI 10.1002/ijc.24689
   Watzl B, 2003, ANN NUTR METAB, V47, P255, DOI 10.1159/000072397
NR 28
TC 95
Z9 100
U1 0
U2 30
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD JUN 14
PY 2013
VL 109
IS 11
BP 2031
EP 2035
DI 10.1017/S0007114512004278
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 146WT
UT WOS:000319126700013
PM 23069270
OA Bronze
DA 2025-06-11
ER

PT J
AU Stubbs, B
AF Stubbs, B.
TI Antipsychotic-induced hyperprolactinaemia in patients with
   schizophrenia: considerations in relation to bone mineral density
SO JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING
LA English
DT Article
DE antipsychotic medication; hyperprolactinaemia; osteoporosis; physical
   health & considerations into nursing practice; schizophrenia
ID CIGARETTE-SMOKING; PROLACTIN LEVELS; HIP FRACTURE; OSTEOPOROSIS;
   PREVALENCE; WOMEN; RISK; PATHOPHYSIOLOGY; RISPERIDONE; DEPRESSION
AB Schizophrenia affects about 1% of the world's population. Those with schizophrenia are at elevated risk of a variety of physical health conditions, including diabetes, coronary heart disease, hypertension and osteoporosis. Osteoporosis secondary to antipsychotic-induced hyperprolactinaemia (i.e. raised prolactin levels) has received little attention, when compared with reports on metabolic syndrome for instance. A recent study established that schizophrenia and prolactin-raising antipsychotic medication is directly associated with hip fractures. This is important and concerning as osteoporotic fractures are associated with much morbidity and mortality. This paper reviews the literature on antipsychotic-induced hyperprolactinaemia and its subsequent effects on bone mineral density.
RP Stubbs, B (corresponding author), Gallowgate House,Bedford Rd W, Northampton NN7 1HB, England.
EM brendonstubbs@hotmail.com
RI Stubbs, Brendon/X-1904-2018; Stubbs, Brendon/C-5696-2015
OI Stubbs, Brendon/0000-0001-7387-3791
CR [Anonymous], 2000, NIH Consens Statement, V17, P1
   BEUMONT PJV, 1974, BRIT J PSYCHIAT, V124, P413, DOI 10.1192/bjp.124.5.413
   Bushe Chris, 2008, J Psychopharmacol, V22, P46, DOI 10.1177/0269881107088435
   Bushe C, 2007, J PSYCHOPHARMACOL, V21, P768, DOI 10.1177/0269881107078281
   Bushe Chris, 2008, J Psychopharmacol, V22, P56, DOI 10.1177/0269881107088436
   Coss D, 2000, AM J PHYSIOL-ENDOC M, V279, pE1216, DOI 10.1152/ajpendo.2000.279.6.E1216
   DANIELL HW, 1976, ARCH INTERN MED, V136, P298, DOI 10.1001/archinte.136.3.298
   GOFF DC, 1992, AM J PSYCHIAT, V149, P1189
   Haddad PM, 2004, DRUGS, V64, P2291, DOI 10.2165/00003495-200464200-00003
   Halbreich U, 2003, PSYCHONEUROENDOCRINO, V28, P53, DOI 10.1016/S0306-4530(02)00112-9
   Hobson EE, 2001, CLIN ENDOCRINOL, V54, P1, DOI 10.1046/j.1365-2265.2001.01149.x
   Holt Richard I G, 2008, J Psychopharmacol, V22, P28, DOI 10.1177/0269881107087951
   Howard L, 2007, BRIT J PSYCHIAT, V190, P129, DOI 10.1192/bjp.bp.106.023671
   Hummer M, 2005, AM J PSYCHIAT, V162, P162, DOI 10.1176/appi.ajp.162.1.162
   Jeong CY, 2005, J CLIN PSYCHOPHARM, V25, P613, DOI 10.1097/01.jcp.0000186738.84276.9f
   Jung DU, 2006, J CLIN PSYCHIAT, V67, P1391, DOI 10.4088/JCP.v67n0909
   Kleinberg DL, 1999, J CLIN PSYCHOPHARM, V19, P57, DOI 10.1097/00004714-199902000-00011
   Kohen Dora, 2008, J Psychopharmacol, V22, P6, DOI 10.1177/0269216307087147
   Law MR, 1997, BMJ-BRIT MED J, V315, P841, DOI 10.1136/bmj.315.7112.841
   LINKOWSKI P, 1989, ARCH GEN PSYCHIAT, V46, P813
   Liu H, 2008, ANN INTERN MED, V148, P685, DOI 10.7326/0003-4819-148-9-200805060-00009
   Marder SR, 2004, AM J PSYCHIAT, V161, P1334, DOI 10.1176/appi.ajp.161.8.1334
   Meaney AM, 2007, SCHIZOPHR RES, V93, P136, DOI 10.1016/j.schres.2007.01.013
   Michelson D, 1996, NEW ENGL J MED, V335, P1176, DOI 10.1056/NEJM199610173351602
   Montgomery J, 2004, J CLIN PSYCHIAT, V65, P1491, DOI 10.4088/JCP.v65n1108
   Naidoo U, 2003, PSYCHONEUROENDOCRINO, V28, P97, DOI 10.1016/S0306-4530(02)00129-4
   O'Keane V, 2005, J CLIN PSYCHOPHARM, V25, P26, DOI 10.1097/01.jcp.0000150223.31007.e0
   Peveler Robert C, 2008, J Psychopharmacol, V22, P98, DOI 10.1177/0269881107087346
   Schooler N, 2005, AM J PSYCHIAT, V162, P947, DOI 10.1176/appi.ajp.162.5.947
   Stubbs B, 2009, INT PSYCHOGERIATR, V21, P180, DOI 10.1017/S1041610208007849
   Tyler CV, 2000, MENT RETARD, V38, P316, DOI 10.1352/0047-6765(2000)038<0316:SFOICA>2.0.CO;2
   Wieck A, 2003, BRIT J PSYCHIAT, V182, P199, DOI 10.1192/bjp.182.3.199
   Wieck A, 2002, BRIT MED J, V324, P250, DOI 10.1136/bmj.324.7332.250
   World Health Organization, 1994, TECHN REP SER, V843
   Yirmiya R, 2006, P NATL ACAD SCI USA, V103, P16876, DOI 10.1073/pnas.0604234103
NR 35
TC 25
Z9 28
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1351-0126
EI 1365-2850
J9 J PSYCHIATR MENT HLT
JI J. Psychiatr. Ment. Health Nurs.
PD NOV
PY 2009
VL 16
IS 9
BP 838
EP 842
DI 10.1111/j.1365-2850.2009.01472.x
PG 5
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 505WE
UT WOS:000270729200008
PM 19824978
DA 2025-06-11
ER

PT J
AU Nowowiejska, J
   Baran, A
   Flisiak, I
AF Nowowiejska, Julia
   Baran, Anna
   Flisiak, Iwona
TI Sleep disorders in psoriasis
SO PRZEGLAD DERMATOLOGICZNY
LA English
DT Review
DE psoriasis; sleep; sleep disturbances; obstructive sleep apnea; restless
   leg syndrome
ID QUALITY-OF-LIFE; DISEASE
AB Psoriasis is a chronic inflammatory skin disease affecting 2-4% of general population. Skin lesions may be accompanied by pruritus or pain, what may cause difficulties in daily functioning, and also disturb sleep. Many patients suffer from depression, which is often accompanied by sleep disorders, usually insomnia. Psoriasis is also strongly associated with metabolic syndrome and obesity, but also with obstructive sleep apnea syndrome. Research also shows that patients with psoriasis more frequently suffer from restless leg syndrome. Sleep disorders lead to significant deterioration of patients' quality of life, which is already decreased by the disease itself. Therefore, it is advisable to screen patients with psoriasis for sleep disorders, and introduce adequate treatment early during the course of the disease.
C1 [Nowowiejska, Julia; Baran, Anna; Flisiak, Iwona] Med Univ Bialystok, Dept Dermatol & Venereol, Bialystok, Poland.
C3 Medical University of Bialystok
RP Baran, A (corresponding author), Uniwersytet Med, Klin Dermatol & Wenerol, Ul Zurawia 14, PL-15540 Bialystok, Poland.
EM anna.baran@umb.edu.pl
RI Flisiak, Iwona/R-5874-2018; Baran, Anna/T-6630-2018; Nowowiejska,
   Julia/AAR-6020-2021
OI Nowowiejska, Julia/0000-0002-6870-1167
CR Amanat M, 2018, REV NEUROSCIENCE, V29, P805, DOI 10.1515/revneuro-2017-0108
   Baran A, 2017, PRZ DERMATOL, V104, P619, DOI 10.5114/dr.2017.71834
   Bronkowska Monika, 2010, Rocz Panstw Zakl Hig, V61, P317
   Drakatos P, 2015, J THORAC DIS, V7, P897, DOI 10.3978/j.issn.2072-1439.2014.06.11
   Galecki P., 2018, EDRA URBAN PARTNER, P279
   Guo SY, 2017, FRONT AGING NEUROSCI, V9, DOI 10.3389/fnagi.2017.00171
   Gupta MA, 2016, SLEEP MED REV, V29, P63, DOI 10.1016/j.smrv.2015.09.003
   Hawro T, 2020, ARCH DERMATOL RES, V312, P103, DOI 10.1007/s00403-019-01998-7
   Henry AL, 2019, BRIT J DERMATOL, V180, P1397, DOI 10.1111/bjd.17685
   Hirotsu C, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051183
   Hurlston A, 2019, MIL MED, V184, pE701, DOI 10.1093/milmed/usz066
   Irwin MR, 2016, BIOL PSYCHIAT, V80, P40, DOI 10.1016/j.biopsych.2015.05.014
   Jensen P, 2018, BRIT J DERMATOL, V179, P1376, DOI 10.1111/bjd.16702
   Kaaz K, 2019, POSTEP DERM ALERGOL, V36, P659, DOI 10.5114/ada.2019.84007
   Koo J, 1996, DERMATOL CLIN, V14, P485, DOI 10.1016/S0733-8635(05)70376-4
   Krajewska-Wlodarczyk Magdalena, 2018, Reumatologia (Warsaw), V56, P301, DOI 10.5114/reum.2018.79501
   Melikoglu M, 2017, EURASIAN J MED, V49, P124, DOI 10.5152/eurasianjmed.2017.17132
   Papadavid E, 2017, SLEEP BREATH, V21, P949, DOI 10.1007/s11325-017-1507-4
   Pilz LK, 2018, SLEEP, V41, DOI 10.1093/sleep/zsy029
   Plywaczewski R., 2017, MED PRAKTYCZNA
   Rapp SR, 1999, J AM ACAD DERMATOL, V41, P401, DOI 10.1016/S0190-9622(99)70112-X
   Reich A, 2020, PRZ DERMATOL, V107, P92, DOI 10.5114/dr.2020.95258
   Ryan C, 2015, DERMATOL CLIN, V33, P41, DOI 10.1016/j.det.2014.09.004
   Salman A, 2018, AN BRAS DERMATOL, V93, P819
   Sandikci SC, 2019, Z RHEUMATOL, V78, P987, DOI 10.1007/s00393-018-0562-y
   Schell C, 2015, EUR J DERMATOL, V25, P255, DOI 10.1684/ejd.2015.2525
   Shutty Brandon G, 2013, Dermatol Online J, V19, P1
   Stenholm S, 2019, J GERONTOL A-BIOL, V74, P204, DOI 10.1093/gerona/gly016
   Thorpy MJ, 2012, NEUROTHERAPEUTICS, V9, P687, DOI 10.1007/s13311-012-0145-6
NR 29
TC 6
Z9 6
U1 0
U2 11
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 0033-2526
EI 2084-9893
J9 PRZ DERMATOL
JI Prz. Dermatol.
PY 2020
VL 107
IS 3
BP 273
EP 280
DI 10.5114/dr.2020.97780
PG 8
WC Dermatology
WE Emerging Sources Citation Index (ESCI)
SC Dermatology
GA NJ2GT
UT WOS:000565864500007
OA gold
DA 2025-06-11
ER

PT J
AU Yang, LL
   Yang, HD
   He, MA
   Pan, A
   Li, XL
   Min, XW
   Zhang, C
   Xu, CW
   Zhu, XY
   Yuan, J
   Wei, S
   Miao, XP
   Hu, FB
   Wu, TC
   Zhang, XM
AF Yang, Liangle
   Yang, Handong
   He, Meian
   Pan, An
   Li, Xiulou
   Min, Xinwen
   Zhang, Ce
   Xu, Chengwei
   Zhu, Xiaoyan
   Yuan, Jing
   Wei, Sheng
   Miao, Xiaoping
   Hu, Frank B.
   Wu, Tangchun
   Zhang, Xiaomin
TI Longer Sleep Duration and Midday Napping Are Associated with a Higher
   Risk of CHD Incidence in Middle-Aged and Older Chinese: the
   Dongfeng-Tongji Cohort Study
SO SLEEP
LA English
DT Article
DE sleep duration; midday napping; incident CHD; prospective studies;
   follow-up
ID CORONARY-HEART-DISEASE; CAUSE-SPECIFIC MORTALITY;
   CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY; ALL-CAUSE; PSYCHOLOGICAL
   STRESS; METABOLIC SYNDROME; TASK-FORCE; FOLLOW-UP; WOMEN
AB Study Objectives: To analyze the independent and combined relations of sleep duration and midday napping with coronary heart diseases (CHD) incidence along with the underlying changes of cardiovascular disease (CVD) risk factors among Chinese adults.
   Methods: We included 19,370 individuals aged 62.8 years at baseline from September 2008 to June 2010, and they were followed until October 2013. Cox proportional hazards models and general linear models were used for multivariate longitudinal analyses.
   Results: Compared with sleeping 7-< 8 h/night, the hazard ratio (HR) of CHD incidence was 1.33 (95% CI = 1.10 to 1.62) for sleeping >= 10 h/night. The association was particularly evident among individuals who were normal weight and without diabetes. Similarly, the HR of incident CHD was 1.25 (95% CI = 1.05 to 1.49) for midday napping > 90 min compared with 1-30 min. When sleep duration and midday napping were combined, individuals having sleep duration >= 10 h and midday napping > 90 min were at a greater risk of CHD than those with sleeping 7-< 8 h and napping 1-30 min: the HR was 1.67 (95% CI = 1.04 to 2.66; P for trend = 0.017). In addition, longer sleep duration >= 10 h was significantly associated with increases in triglycerides and waist circumference, and a reduction in HDL-cholesterol; while longer midday napping > 90 min was related to increased waist circumference.
   Conclusions: Both longer sleep duration and midday napping were independently and jointly associated with a higher risk of CHD incidence, and altered lipid profile and waist circumference may partially explain the relationships.
C1 [Yang, Liangle; He, Meian; Zhu, Xiaoyan; Yuan, Jing; Wu, Tangchun; Zhang, Xiaomin] Huazhong Univ Sci & Technol, Dept Occupat & Environm Hlth, Wuhan 430030, Peoples R China.
   [Yang, Liangle; He, Meian; Zhu, Xiaoyan; Yuan, Jing; Wu, Tangchun; Zhang, Xiaomin] Huazhong Univ Sci & Technol, Minist Educ, Key Lab Environm & Hlth, Sch Publ Hlth,Tongji Med Coll, Wuhan 430030, Peoples R China.
   [Yang, Handong; Li, Xiulou; Min, Xinwen; Zhang, Ce; Xu, Chengwei] Dongfeng Motor Corp, Dongfeng Cent Hosp, Shiyan, Peoples R China.
   [Yang, Handong; Li, Xiulou; Min, Xinwen; Zhang, Ce; Xu, Chengwei] Hubei Univ Med, Shiyan, Peoples R China.
   [Pan, An; Wei, Sheng; Miao, Xiaoping] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Stat, Wuhan 430030, Peoples R China.
   [Xu, Chengwei] Wuhan Univ, Dept Cardiol, Renmin Hosp, Wuhan 430072, Peoples R China.
   [Hu, Frank B.] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
   [Hu, Frank B.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
C3 Huazhong University of Science & Technology; Ministry of Education -
   China; Huazhong University of Science & Technology; Dongfeng Motor;
   Hubei University of Medicine; Huazhong University of Science &
   Technology; Wuhan University; Harvard University; Harvard T.H. Chan
   School of Public Health; Harvard University; Harvard T.H. Chan School of
   Public Health
RP Zhang, XM (corresponding author), Huazhong Univ Sci & Technol, Key Lab Environm & Hlth, Minist Educ, 13 Hangkong Rd, Wuhan 430030, Peoples R China.; Zhang, XM (corresponding author), Huazhong Univ Sci & Technol, Minist Environm Protect, 13 Hangkong Rd, Wuhan 430030, Peoples R China.; Zhang, XM (corresponding author), Huazhong Univ Sci & Technol, State Key Lab Environm Hlth Incubating, Sch Publ Hlth, Tongji Med Coll, 13 Hangkong Rd, Wuhan 430030, Peoples R China.
EM mingxz117@hust.edu.cn
RI XU, CHENGWEI/JCO-9076-2023; Zhang, Xiaomin/F-3206-2018; wei,
   sheng/E-9746-2012; yu, ye/KVB-7532-2024; Xiaoyan, Zhu/AGI-3291-2022; Hu,
   Frank/C-1919-2013; miao, xiaoping/C-4336-2011; Pan, An/C-5572-2011
OI Xiaoyan, Zhu/0000-0003-2246-2196; Min, Xinwen/0000-0002-8429-6560; miao,
   xiaoping/0000-0002-6818-9722; Pan, An/0000-0002-1089-7945
FU Natural National Scientific Foundation of China [81373093, 81230069,
   81390542]; 111 Project [B12004]; Program for Changjiang Scholars;
   Innovative Research Team in University of Ministry of Education of China
   [IRT1246]; China Medical Board [12-113]
FX This was not an industry supported study. This work was supported by the
   Natural National Scientific Foundation of China (81373093,81230069, and
   81390542), 111 Project (No. B12004); and the Program for Changjiang
   Scholars; Innovative Research Team in University of Ministry of
   Education of China (No. IRT1246); China Medical Board (No. 12-113). The
   authors have indicated no financial conflicts of interest.
CR ADAMS HP, 1993, STROKE, V24, P35, DOI 10.1161/01.STR.24.1.35
   Amagai Y, 2010, J EPIDEMIOL, V20, P106, DOI 10.2188/jea.JE20090053
   [Anonymous], 1977, INT CLASS DIS
   Araghi MH, 2012, CLIN LIPIDOL, V7, P443, DOI 10.2217/CLP.12.43
   Arora T, 2011, DIABETES CARE, V34, P2317, DOI 10.2337/dc11-0647
   Ayas NT, 2003, ARCH INTERN MED, V163, P205, DOI 10.1001/archinte.163.2.205
   Cannon CP, 2001, J AM COLL CARDIOL, V38, P2114, DOI 10.1016/S0735-1097(01)01702-8
   Cappuccio FP, 2011, EUR HEART J, V32, P1484, DOI 10.1093/eurheartj/ehr007
   Cappuccio FP, 2010, DIABETES CARE, V33, P414, DOI 10.2337/dc09-1124
   Choi KM, 2008, INT J OBESITY, V32, P1091, DOI 10.1038/ijo.2008.62
   Hoevenaar-Blom MP, 2011, SLEEP, V34, P1487, DOI 10.5665/sleep.1382
   Ikehara S, 2009, SLEEP, V32, P295, DOI 10.1093/sleep/32.3.295
   Kaneita Y, 2008, SLEEP, V31, P645, DOI 10.1093/sleep/31.5.645
   Koenig W, 1997, CIRCULATION, V95, P335
   Lan TY, 2007, SLEEP, V30, P1105, DOI 10.1093/sleep/30.9.1105
   Leng Y, 2015, NEUROLOGY, V84, P1072, DOI 10.1212/WNL.0000000000001371
   Leng Y, 2014, AM J EPIDEMIOL, V179, P1115, DOI 10.1093/aje/kwu036
   Liu J, 2014, NUTR METAB CARDIOVAS, V24, P600, DOI 10.1016/j.numecd.2013.12.012
   Magee CA, 2012, J SLEEP RES, V21, P441, DOI 10.1111/j.1365-2869.2011.00993.x
   Meisinger C, 2007, SLEEP, V30, P1121, DOI 10.1093/sleep/30.9.1121
   Milner CE, 2009, J SLEEP RES, V18, P272, DOI 10.1111/j.1365-2869.2008.00718.x
   Patel SR, 2006, SLEEP, V29, P881, DOI 10.1093/sleep/29.7.881
   Patel SR, 2004, SLEEP, V27, P440, DOI 10.1093/sleep/27.3.440
   Preis SR, 2009, CIRCULATION, V119, P1728, DOI 10.1161/CIRCULATIONAHA.108.829176
   Ramachandruni S, 2004, CURR OPIN CARDIOL, V19, P494, DOI 10.1097/01.hco.0000132321.24004.25
   RAPAPORT E, 1979, CIRCULATION, V59, P607
   Roca GQ, 2013, AM J RESP CRIT CARE, V188, P1460, DOI 10.1164/rccm.201309-1572OC
   Shankar A, 2008, AM J EPIDEMIOL, V168, P1367, DOI 10.1093/aje/kwn281
   Stang A, 2012, SLEEP, V35, P1705, DOI 10.5665/sleep.2248
   Tamaki M, 2000, Sleep Res Online, V3, P131
   Tamakoshi A, 2004, SLEEP, V27, P51
   Tanabe N, 2010, INT J EPIDEMIOL, V39, P233, DOI 10.1093/ije/dyp327
   Theorell-Haglöw J, 2014, SLEEP MED, V15, P1204, DOI 10.1016/j.sleep.2014.02.014
   Thrall G, 2007, THROMB RES, V120, P819, DOI 10.1016/j.thromres.2007.01.004
   TRICHOPOULOS D, 1987, LANCET, V2, P269
   Wang F, 2013, INT J EPIDEMIOL, V42, P731, DOI 10.1093/ije/dys053
   Williams CJ, 2007, DIABETES CARE, V30, P1233, DOI 10.2337/dc06-2107
   World Health Organization, 1990, International classification of diseases
   Xiao Q, 2014, AM J EPIDEMIOL, V180, P997, DOI 10.1093/aje/kwu222
NR 39
TC 64
Z9 72
U1 1
U2 30
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
EI 1550-9109
J9 SLEEP
JI Sleep
PD MAR 1
PY 2016
VL 39
IS 3
BP 645
EP 652
AR PII sp-00311-15
DI 10.5665/sleep.5544
PG 8
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA DF1RB
UT WOS:000371115800019
PM 26564127
OA Green Published, Bronze
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Wang, SH
   Du, QY
   Meng, XL
   Zhang, Y
AF Wang, Shaohui
   Du, Qinyun
   Meng, Xianli
   Zhang, Yi
TI Natural polyphenols: a potential prevention and treatment strategy for
   metabolic syndrome
SO FOOD & FUNCTION
LA English
DT Review
ID NF-KAPPA-B; ELLAGIC ACID PROTECTS; DIET-INDUCED OBESITY; BETA-D-GLUCOSE;
   OXIDATIVE STRESS; INSULIN-RESISTANCE; HEPATIC STEATOSIS; CAFFEIC ACID;
   ENDOTHELIAL-CELLS; GALLIC ACID
AB Metabolic syndrome (MS) is the term for a combination of hypertension, dyslipidemia, insulin resistance, and central obesity as factors leading to cardiovascular and metabolic disease. Epidemiological investigation has shown that polyphenol intake is negatively correlated with the incidence of MS. Natural polyphenols are widely found in cocoa beans, tea, vegetables, fruits, and some Chinese herbal medicines; they are a class of plant compounds containing a variety of phenolic structural units, which are potent antioxidants and anti-inflammatory agents in plants. Polyphenols are composed of flavonoids (such as flavanols, anthocyanidins, anthocyanins, isoflavones, etc.) and non-flavonoids (such as phenolic acids, stilbenes, and lignans). Modern pharmacological studies have proved that polyphenols can reduce blood pressure, improve lipid metabolism, lower blood glucose, and reduce body weight, thereby preventing and improving MS. Due to the unique characteristics and potential development and application value of polyphenols, this review summarizes some natural polyphenols that could treat MS, including their chemical properties, plant sources, and pharmacological action against MS, to provide a basis for the further study of polyphenols in MS.
C1 [Wang, Shaohui; Zhang, Yi] Chengdu Univ Tradit Chinese Med, Sch Ethn Med, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China.
   [Du, Qinyun] Chengdu Univ Tradit Chinese Med, Sch Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China.
   [Meng, Xianli] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine; Chengdu University of Traditional
   Chinese Medicine
RP Zhang, Y (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Ethn Med, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China.; Meng, XL (corresponding author), Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China.
EM xlm999@cdutcm.edu.cn; zhangyi@cdutcm.edu.cn
RI Wang, Shaohui/HKO-6774-2023; Wang, Shengpeng/JOZ-1627-2023
OI Liu, Haibo/0000-0002-4213-2883
FU National Natural Science Foundation of China [82104534]; National Key
   R&D Program of China [2017YFC1703904]; "Xinglin Scholars" Research
   Promotion Program of Chengdu University of Traditional Chinese Medicine
   [BSH2021008]; Sichuan Province Science Research Special Funding Project
   for Postdoctoral Fellows [2022BSH044]
FX This study was supported by the National Natural Science Foundation of
   China (82104534), the National Key R&D Program of China
   (2017YFC1703904), the "Xinglin Scholars" Research Promotion Program of
   Chengdu University of Traditional Chinese Medicine (BSH2021008), and the
   Sichuan Province Science Research Special Funding Project for
   Postdoctoral Fellows (2022BSH044).
CR Abdel-Moneim A, 2018, BIOMED PHARMACOTHER, V105, P1091, DOI 10.1016/j.biopha.2018.06.096
   Ahad A, 2014, CHEM-BIOL INTERACT, V219, P64, DOI 10.1016/j.cbi.2014.05.011
   Akbari FRA, 2019, ACTA ENDOCRINOL-BUCH, V15, P187, DOI 10.4183/aeb.2019.187
   Alsaggar M, 2020, BMC PHARMACOL TOXICO, V21, DOI 10.1186/s40360-020-0385-8
   AMMON HPT, 1991, PLANTA MED, V57, P1, DOI 10.1055/s-2006-960004
   An X, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051516
   Arunachalam G, 2010, BIOCHEM BIOPH RES CO, V393, P66, DOI 10.1016/j.bbrc.2010.01.080
   Basu A, 2010, J NUTR, V140, P1582, DOI 10.3945/jn.110.124701
   Batiha GE, 2020, FOODS, V9, DOI 10.3390/foods9030374
   Bishehsari F, 2020, NAT REV ENDOCRINOL, V16, P731, DOI 10.1038/s41574-020-00427-4
   Cao K, 2020, FOOD FUNCT, V11, P9624, DOI [10.1039/D0FO01545H, 10.1039/d0fo01545h]
   Cao K, 2015, SCI REP-UK, V5, DOI 10.1038/srep14014
   Cao K, 2014, FREE RADICAL BIO MED, V67, P396, DOI 10.1016/j.freeradbiomed.2013.11.029
   Castro-Barquero S, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101523
   Chao J, 2021, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.606759
   Chaplin A, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111651
   Chen SY, 2012, FOOD CHEM TOXICOL, V50, P3025, DOI 10.1016/j.fct.2012.06.006
   Cho AS, 2010, FOOD CHEM TOXICOL, V48, P937, DOI 10.1016/j.fct.2010.01.003
   Cho KW, 2011, EUR J NUTR, V50, P81, DOI 10.1007/s00394-010-0117-8
   Choi YR, 2020, MOLECULES, V25, DOI 10.3390/molecules25092042
   Chtourou Y, 2015, EUR J PHARMACOL, V746, P96, DOI 10.1016/j.ejphar.2014.10.027
   Chu C, 2020, BIOMOL THER, V28, P163
   Dabke K, 2019, J CLIN INVEST, V129, P4050, DOI 10.1172/JCI129194
   Darwish MA, 2021, EUR J PHARMACOL, V901, DOI 10.1016/j.ejphar.2021.174059
   Darwish MA, 2021, LIFE SCI, V272, DOI 10.1016/j.lfs.2021.119250
   DeFuria J, 2009, J NUTR, V139, P1510, DOI 10.3945/jn.109.105155
   Di Lorenzo C, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010273
   Diaz A, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/1358057
   Dong J, 2014, J LIPID RES, V55, P363, DOI 10.1194/jlr.M038786
   Dong ZW, 2019, MOL MED REP, V20, P1383, DOI 10.3892/mmr.2019.10344
   Du CY, 2015, DRUG DES DEV THER, V9, DOI 10.2147/DDDT.S90201
   Ejaz A, 2009, J NUTR, V139, P919, DOI 10.3945/jn.108.100966
   El-Azab MF, 2011, EUR J PHARMACOL, V658, P41, DOI 10.1016/j.ejphar.2011.02.010
   El-Shitany NA, 2014, INT IMMUNOPHARMACOL, V19, P290, DOI 10.1016/j.intimp.2014.02.004
   Eseberri I, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22031384
   Fang PH, 2017, MOL CELL ENDOCRINOL, V448, P77, DOI 10.1016/j.mce.2017.03.027
   Forney LA, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19030895
   Fratantonio D, 2017, BIOFACTORS, V43, P54, DOI 10.1002/biof.1312
   Gan ML, 2020, FOOD FUNCT, V11, P2418, DOI [10.1039/c9fo00861f, 10.1039/C9FO00861F]
   Garud MS, 2018, CHEM-BIOL INTERACT, V282, P69, DOI 10.1016/j.cbi.2018.01.010
   Gierach Marcin, 2014, ISRN Endocrinol, V2014, P514589, DOI 10.1155/2014/514589
   Giménez-Bastida JA, 2012, J AGR FOOD CHEM, V60, P8866, DOI 10.1021/jf300290f
   Goldwasser J, 2010, PLOS ONE, V5, DOI [10.1371/journal.pone.0012399, 10.1371/journal.pone.0013842]
   Guo HX, 2009, ACTA PHARMACOL SIN, V30, P1505, DOI 10.1038/aps.2009.150
   Guo HH, 2012, J NUTR BIOCHEM, V23, P349, DOI 10.1016/j.jnutbio.2010.12.013
   Guo HH, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-10
   Han XZ, 2007, INT J MOL SCI, V8, P950, DOI 10.3390/i8090950
   Hashimoto T, 2015, J AGR FOOD CHEM, V63, P9536, DOI 10.1021/acs.jafc.5b03734
   Henagan TM, 2015, GENES NUTR, V10, DOI 10.1007/s12263-014-0451-1
   Hernández-Aquino E, 2018, WORLD J GASTROENTERO, V24, P1679, DOI 10.3748/wjg.v24.i16.1679
   Hosseini A, 2021, PHYTOTHER RES, V35, P5352, DOI 10.1002/ptr.7144
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Hseu YC, 2012, FOOD CHEM TOXICOL, V50, P1245, DOI 10.1016/j.fct.2012.02.020
   Huang WY, 2014, MOLECULES, V19, P12827, DOI 10.3390/molecules190812827
   Huang YJ, 2020, APPL PHYSIOL NUTR ME, V45, P227, DOI 10.1139/apnm-2019-0057
   Hursel R, 2013, AM J CLIN NUTR, V98, p1682S, DOI 10.3945/ajcn.113.058396
   Ibitoye Oluwayemisi B, 2018, Arch Physiol Biochem, V124, P410, DOI 10.1080/13813455.2017.1415938
   Ikeda I, 2005, BIOSCI BIOTECH BIOCH, V69, P1049, DOI 10.1271/bbb.69.1049
   Ishimoto H, 2011, BIOORG MED CHEM LETT, V21, P5901, DOI 10.1016/j.bmcl.2011.07.086
   Jimoh A, 2018, Pathophysiology, V25, P411, DOI 10.1016/j.pathophys.2018.08.005
   Jin D, 2020, FOOD FUNCT, V11, P10617, DOI [10.1039/d0fo01275k, 10.1039/D0FO01275K]
   Joseph SV, 2016, CRIT REV FOOD SCI, V56, P419, DOI 10.1080/10408398.2013.767221
   Jung UJ, 2006, J PHARMACOL EXP THER, V318, P476, DOI 10.1124/jpet.106.105163
   Kang B, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201900574
   Kang OH, 2013, EUR REV MED PHARMACO, V17, P2578
   Kant R, 2020, BIOMED PHARMACOTHER, V129, DOI 10.1016/j.biopha.2020.110348
   Keaver L, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0079827
   Kim HM, 2018, NUTRITION, V55-56, P63, DOI 10.1016/j.nut.2018.03.010
   Kobori M, 2011, MOL NUTR FOOD RES, V55, P530, DOI 10.1002/mnfr.201000392
   Korovila I, 2020, MOL NUTR FOOD RES, V64, DOI 10.1002/mnfr.202000816
   Kuo YT, 2019, J FOOD DRUG ANAL, V27, P240, DOI 10.1016/j.jfda.2018.07.002
   Kwon EY, 2015, DIABETES, V64, P1658, DOI 10.2337/db14-0631
   Lagouge M, 2006, CELL, V127, P1109, DOI 10.1016/j.cell.2006.11.013
   Larrosa M, 2006, J AGR FOOD CHEM, V54, P1611, DOI 10.1021/jf0527403
   Leclercq IA, 2004, J HEPATOL, V41, P926, DOI 10.1016/j.jhep.2004.08.010
   Lee CH, 2001, BIOCHEM BIOPH RES CO, V284, P681, DOI 10.1006/bbrc.2001.5001
   Lee D, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112702
   Lee ES, 2012, J AGR FOOD CHEM, V60, P2730, DOI 10.1021/jf203774y
   Lee H, 2010, BIOCHEM BIOPH RES CO, V398, P741, DOI 10.1016/j.bbrc.2010.07.015
   Lee JS, 2015, MOL MED REP, V11, P2723, DOI 10.3892/mmr.2014.3078
   Leri M, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21041250
   Li JM, 2010, HEPATOLOGY, V51, P1555, DOI 10.1002/hep.23524
   Li YS, 2005, BIOCHEM BIOPH RES CO, V336, P430, DOI 10.1016/j.bbrc.2005.08.103
   Liao CC, 2013, J AGR FOOD CHEM, V61, P11082, DOI 10.1021/jf4026647
   Liu HH, 2021, MOL NUTR FOOD RES, V65, DOI 10.1002/mnfr.202001031
   Liu J, 2020, INT IMMUNOPHARMACOL, V80, DOI 10.1016/j.intimp.2020.106208
   Liu L, 2008, PHYTOTHER RES, V22, P1400, DOI 10.1002/ptr.2504
   Liu Y, 2014, AM J PHYSIOL-ENDOC M, V306, pE975, DOI 10.1152/ajpendo.00699.2013
   Liu YN, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0127813
   Makihara H, 2016, BIOL PHARM BULL, V39, P1137, DOI 10.1248/bpb.b16-00064
   Maksymchuk O, 2017, PHARMACOL REP, V69, P1386, DOI 10.1016/j.pharep.2017.05.020
   Manach C, 2005, AM J CLIN NUTR, V81, p230S, DOI 10.1093/ajcn/81.1.230S
   Manchope MF, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0153015
   Matsukawa T, 2017, J NUTR BIOCHEM, V40, P77, DOI 10.1016/j.jnutbio.2016.09.018
   Méndez-del Villar M, 2014, METAB SYNDR RELAT D, V12, P497, DOI 10.1089/met.2014.0082
   Mohan CG, 2013, PHYTOMEDICINE, V20, P417, DOI 10.1016/j.phymed.2012.12.020
   Mojzer EB, 2016, MOLECULES, V21, DOI 10.3390/molecules21070901
   Mollace V, 2019, ENDOCR METAB IMMUNE, V19, P136, DOI 10.2174/1871530319666181203151513
   Molonia MS, 2020, ARCH BIOCHEM BIOPHYS, V691, DOI 10.1016/j.abb.2020.108488
   Murase T, 2002, INT J OBESITY, V26, P1459, DOI 10.1038/sj.ijo.0802141
   Murray M, 2018, CRIT REV FOOD SCI, V58, P2039, DOI 10.1080/10408398.2017.1301876
   Nani A, 2021, MOLECULES, V26, DOI 10.3390/molecules26040985
   Natarelli L, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0142421
   OHNO T, 1993, ENDOCR RES, V19, P273, DOI 10.1080/07435809309026682
   Panickar KS, 2013, MOL NUTR FOOD RES, V57, P34, DOI 10.1002/mnfr.201200431
   Paraíso AF, 2019, LIFE SCI, V237, DOI 10.1016/j.lfs.2019.116914
   Park HJ, 2011, J NUTR BIOCHEM, V22, P393, DOI 10.1016/j.jnutbio.2010.03.009
   Park HS, 2016, J TRANSL MED, V14, DOI 10.1186/s12967-016-0922-9
   Peng JM, 2019, CHEM-BIOL INTERACT, V302, P156, DOI 10.1016/j.cbi.2019.01.037
   Pinho-Ribeiro FA, 2016, J NUTR BIOCHEM, V33, P8, DOI 10.1016/j.jnutbio.2016.03.013
   Piwowarski JP, 2015, MOL NUTR FOOD RES, V59, P2168, DOI 10.1002/mnfr.201500264
   Pummoung S, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10010024
   Quideau S, 2011, ANGEW CHEM INT EDIT, V50, P586, DOI 10.1002/anie.201000044
   Malarvizhi R, 2021, J FOOD BIOCHEM, V45, DOI 10.1111/jfbc.13595
   Rahimifard M, 2020, MOLECULES, V25, DOI 10.3390/molecules25245875
   Rietjens SJ, 2007, AM J PHYSIOL-HEART C, V292, pH1931, DOI 10.1152/ajpheart.00755.2006
   Rizvi AA, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms221810038
   Rojas M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13072254
   Rojo LE, 2012, FOOD CHEM, V131, P387, DOI 10.1016/j.foodchem.2011.08.066
   Roy M, 2008, LIFE SCI, V82, P1102, DOI 10.1016/j.lfs.2008.03.011
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Salem AM, 2019, INDIAN J CLIN BIOCHE, V34, P296, DOI 10.1007/s12291-018-0743-0
   Samadder A, 2016, ENVIRON TOXICOL PHAR, V43, P27, DOI 10.1016/j.etap.2016.02.010
   Sánchez-González C, 2014, FOOD FUNCT, V5, P2922, DOI [10.1039/c4fo00542b, 10.1039/C4FO00542B]
   Rie S, 2007, BIOCHEM PHARMACOL, V74, P1619, DOI 10.1016/j.bcp.2007.08.008
   Schreckinger ME, 2010, J AGR FOOD CHEM, V58, P8966, DOI 10.1021/jf100975m
   Sherling DH, 2017, J CARDIOVASC PHARM T, V22, P365, DOI 10.1177/1074248416686187
   Singla RK, 2019, J AOAC INT, V102, P1397, DOI [10.1093/jaoac/102.5.1397, 10.5740/jaoacint.19-0133]
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Sousa JN, 2020, EXP GERONTOL, V134, DOI 10.1016/j.exger.2020.110881
   Späh F, 2008, BRIT J DERMATOL, V159, P10, DOI 10.1111/j.1365-2133.2008.08780.x
   Sudheer AR, 2007, TOXICOLOGY, V230, P11, DOI 10.1016/j.tox.2006.10.010
   Sun X, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-01357-w
   Surapaneni KM, 2014, EUR REV MED PHARMACO, V18, P2736
   Suzuki A, 2007, AM J HYPERTENS, V20, P508, DOI 10.1016/j.amjhyper.2006.11.008
   Suzuki R, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-14
   Szkudelska K, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22052469
   Tanaka M, 2020, NUTR RES, V73, P58, DOI 10.1016/j.nutres.2019.09.007
   Umesalma S, 2010, BASIC CLIN PHARMACOL, V107, P650, DOI 10.1111/j.1742-7843.2010.00565.x
   Ungvari Z, 2010, AM J PHYSIOL-HEART C, V299, pH18, DOI 10.1152/ajpheart.00260.2010
   van Dijk AE, 2009, DIABETES CARE, V32, P1023, DOI 10.2337/dc09-0207
   Variya BC, 2020, PHYTOMEDICINE, V73, DOI 10.1016/j.phymed.2019.152906
   Vinayak M, 2019, ANTI-CANCER AGENT ME, V19, P1560, DOI 10.2174/1871520619666190705150214
   Vizzutti F, 2010, LAB INVEST, V90, P104, DOI 10.1038/labinvest.2009.112
   Wang S, 2014, J NUTR BIOCHEM, V25, P363, DOI 10.1016/j.jnutbio.2013.10.002
   Wang YL, 2014, EXP THER MED, V7, P663, DOI 10.3892/etm.2013.1461
   Wei XY, 2011, J SCI FOOD AGR, V91, P1006, DOI 10.1002/jsfa.4275
   Wein S, 2010, EUR J PHARM SCI, V41, P16, DOI 10.1016/j.ejps.2010.05.004
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Weisberg SP, 2008, ENDOCRINOLOGY, V149, P3549, DOI 10.1210/en.2008-0262
   Wen KM, 2021, CURR MED CHEM, V28, P1042, DOI 10.2174/0929867327666200713184138
   Winand J, 2014, FOOD FUNCT, V5, P310, DOI 10.1039/c3fo60443h
   Wu YL, 2018, BIOMED PHARMACOTHER, V97, P1673, DOI 10.1016/j.biopha.2017.12.024
   Xu D, 2019, MOLECULES, V24, DOI 10.3390/molecules24061123
   Xu DP, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18010096
   Xu FX, 2018, FOOD FUNCT, V9, P4926, DOI 10.1039/c8fo00565f
   Yan CH, 2016, MOL NUTR FOOD RES, V60, P1139, DOI 10.1002/mnfr.201500490
   Yang JY, 2021, PHARMACOL REP, V73, P1230, DOI 10.1007/s43440-021-00227-1
   Yao JY, 2013, BRAZ J MED BIOL RES, V46, P270, DOI 10.1590/1414-431X20122551
   Yin CY, 2020, J FOOD BIOCHEM, V44, DOI 10.1111/jfbc.13380
   You YL, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201700261
   Zeng WF, 2018, PHARMACOL RES, V135, P122, DOI 10.1016/j.phrs.2018.08.002
   Zhang SY, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22116110
   Zhang WL, 2021, AGING-US, V13, P10659, DOI 10.18632/aging.202830
   Zhang YH, 2010, INFLAMM RES, V59, P723, DOI 10.1007/s00011-010-0183-7
   Zhao YT, 2020, J AGR FOOD CHEM, V68, P7416, DOI 10.1021/acs.jafc.0c03286
   Zhong XQ, 2018, BIOMED PHARMACOTHER, V98, P111, DOI 10.1016/j.biopha.2017.12.026
   Zhou Y, 2016, NUTRIENTS, V8, DOI 10.3390/nu8080515
NR 168
TC 51
Z9 54
U1 11
U2 63
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD OCT 3
PY 2022
VL 13
IS 19
BP 9734
EP 9753
DI 10.1039/d2fo01552h
EA SEP 2022
PG 20
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA 5B1UD
UT WOS:000858372600001
PM 36134531
DA 2025-06-11
ER

PT J
AU Jing, F
   Mogi, M
   Horiuchi, M
AF Jing, Fei
   Mogi, Masaki
   Horiuchi, Masatsugu
TI Role of renin-angiotensin-aldosterone system in adipose tissue
   dysfunction
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Review
DE Angiotensin II; Aldosterone; Adipose tissue; Metabolic sysdrome
ID INDUCED INSULIN-RESISTANCE; TYPE-1 RECEPTOR BLOCKERS; MINERALOCORTICOID
   RECEPTOR; METABOLIC SYNDROME; ADIPOCYTE DIFFERENTIATION;
   DIABETES-MELLITUS; PREADIPOSE CELLS; OXIDATIVE STRESS; GENE-EXPRESSION;
   AT(2) RECEPTOR
AB The renin-angiotensin-aldosterone system (RAAS) is known to be closely linked to the pathogenesis of insulin resistance. The angiotensin (Ang) II type 1 (AT(1)) receptor mediates the major effects of Ang II in adipose tissue, and blockade of the AT(1) receptor improves insulin sensitivity, with enhanced adipocyte differentiation. In contrast, the role of angiotensin type 2 (AT(2)) receptor activation in insulin sensitivity is still controversial, although AT(2) receptor functions are thought to be mutually antagonistic against those of the AT(1) receptor in the cardiovascular system. Aldosterone exerts its biological roles via the mineral-corticoid receptor (MR), and inhibition of MR signaling in adipose tissue ameliorates inflammation, with upregulation of insulin-mediated glucose transport and adipocyte differentiation. Clinical studies indicate that blockade of RAAS prevents the new onset of type 2 diabetes and improves the metabolic syndrome in diabetic patients. We here review the recent concepts of the roles of RAAS in adipose tissue. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
C1 [Jing, Fei; Mogi, Masaki; Horiuchi, Masatsugu] Ehime Univ, Dept Mol Cardiovasc Biol & Pharmacol, Grad Sch Med, Tohon, Ehime 7910295, Japan.
C3 Ehime University
RP Horiuchi, M (corresponding author), Ehime Univ, Dept Mol Cardiovasc Biol & Pharmacol, Grad Sch Med, Tohon, Ehime 7910295, Japan.
EM horiuchi@m.ehime-u.ac.jp
RI Mogi, Masaki/ABH-2011-2020
CR Abu-Elheiga L, 2003, P NATL ACAD SCI USA, V100, P10207, DOI 10.1073/pnas.1733877100
   Ahima RS, 2006, OBESITY, V14, P242, DOI 10.1038/oby.2006.317
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Anghel SI, 2007, J BIOL CHEM, V282, P29946, DOI 10.1074/jbc.M702490200
   Barzilay JI, 2006, ARCH INTERN MED, V166, P2191, DOI 10.1001/archinte.166.20.2191
   CAMPBELL DJ, 1987, ENDOCRINOLOGY, V121, P1616, DOI 10.1210/endo-121-5-1616
   Caprio M, 2007, FASEB J, V21, P2185, DOI 10.1096/fj.06-7970com
   Caprio M, 2011, ENDOCRINOLOGY, V152, P113, DOI 10.1210/en.2010-0674
   Catena C, 2006, J CLIN ENDOCR METAB, V91, P3457, DOI 10.1210/jc.2006-0736
   Connell JMC, 2005, J ENDOCRINOL, V186, P1, DOI 10.1677/joe.1.06017
   Crandall DL, 1999, ENDOCRINOLOGY, V140, P154, DOI 10.1210/en.140.1.154
   DARIMONT C, 1994, ENDOCRINOLOGY, V135, P2030, DOI 10.1210/en.135.5.2030
   Devereux RB, 2004, CIRCULATION, V110, P1456, DOI 10.1161/01.CIR.0000141573.44737.5A
   Dzau V, 2005, J HYPERTENS, V23, pS9, DOI 10.1097/01.hjh.0000165623.72310.dd
   EDWARDS CRW, 1988, LANCET, V2, P986, DOI 10.1016/S0140-6736(88)90742-8
   Ehrhart-Bornstein M, 2003, P NATL ACAD SCI USA, V100, P14211, DOI 10.1073/pnas.2336140100
   Elliott WJ, 2007, LANCET, V369, P201, DOI 10.1016/S0140-6736(07)60108-1
   Engeli S, 1999, J HYPERTENS, V17, P555, DOI 10.1097/00004872-199917040-00014
   Fujimoto M, 2004, FEBS LETT, V576, P492, DOI 10.1016/j.febslet.2004.09.027
   FUNDER JW, 1988, SCIENCE, V242, P583, DOI 10.1126/science.2845584
   Funder JW, 2005, HEART FAIL REV, V10, P15, DOI 10.1007/s10741-005-2344-2
   Furuhashi M, 2004, J HYPERTENS, V22, P1977, DOI 10.1097/00004872-200410000-00021
   Gillespie EL, 2005, DIABETES CARE, V28, P2261, DOI 10.2337/diacare.28.9.2261
   Goodfriend TL, 2004, HYPERTENSION, V43, P358, DOI 10.1161/01.HYP.0000113294.06704.64
   Hajer GR, 2008, EUR HEART J, V29, P2959, DOI 10.1093/eurheartj/ehn387
   Hausman D B, 2001, Obes Rev, V2, P239, DOI 10.1046/j.1467-789X.2001.00042.x
   Hirata A, 2009, CARDIOVASC RES, V84, P164, DOI 10.1093/cvr/cvp191
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Iwai M, 2009, AM J HYPERTENS, V22, P784, DOI 10.1038/ajh.2009.85
   Jeon JH, 2008, FASEB J, V22, P1502, DOI 10.1096/fj.07-9412com
   Jones BH, 1997, AM J PHYSIOL-REG I, V273, pR236, DOI 10.1152/ajpregu.1997.273.1.R236
   Kalupahana N.S., 2011, OBESITY, DOI DOI 10.1038/0BY.2011.299
   Kurata A, 2006, KIDNEY INT, V70, P1717, DOI 10.1038/sj.ki.5001810
   Lapointe N, 2002, CAN J CARDIOL, V18, P415
   Lastra-Lastra G, 2009, CLIN ENDOCRINOL, V71, P1, DOI 10.1111/j.1365-2265.2008.03498.x
   Lind L, 2003, ATHEROSCLEROSIS, V169, P203, DOI 10.1016/S0021-9150(03)00012-1
   MARVER D, 1974, P NATL ACAD SCI USA, V71, P1431, DOI 10.1073/pnas.71.4.1431
   Marzolla V., 2011, MOL CELL ENDOCRINOL
   Massiéra F, 2001, FASEB J, V15, P2727, DOI 10.1096/fj.01-0457fje
   Matsushita K, 2006, HYPERTENSION, V48, P1095, DOI 10.1161/01.HYP.0000248211.82232.a7
   Maury E, 2010, MOL CELL ENDOCRINOL, V314, P1, DOI 10.1016/j.mce.2009.07.031
   Nagase M, 2007, HYPERTENSION, V50, P877, DOI 10.1161/HYPERTENSIONAHA.107.091058
   Nagase M, 2006, J AM SOC NEPHROL, V17, P3438, DOI 10.1681/ASN.2006080944
   Ndisang JF, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/359732
   Neels JG, 2006, J CLIN INVEST, V116, P33, DOI 10.1172/JCI27280
   Olivares-Reyes JA, 2009, MOL CELL ENDOCRINOL, V302, P128, DOI 10.1016/j.mce.2008.12.011
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Pitt B, 2003, NEW ENGL J MED, V348, P1309, DOI 10.1056/NEJMoa030207
   Pitt B, 1999, NEW ENGL J MED, V341, P709, DOI 10.1056/NEJM199909023411001
   Rosen ED, 1999, MOL CELL, V4, P611, DOI 10.1016/S1097-2765(00)80211-7
   Sabuhi R, 2011, AM J PHYSIOL-RENAL, V300, pF700, DOI 10.1152/ajprenal.00616.2010
   Saint-Marc P, 2001, ENDOCRINOLOGY, V142, P487, DOI 10.1210/en.142.1.487
   Scavo LM, 2004, J CLIN ENDOCR METAB, V89, P3543, DOI 10.1210/jc.2003-031682
   Scheen AJ, 2004, DIABETES METAB, V30, P487, DOI 10.1016/S1262-3636(07)70146-5
   Schling P, 2002, HORM METAB RES, V34, P709, DOI 10.1055/s-2002-38240
   Schölkens BA, 2002, CAN J PHYSIOL PHARM, V80, P354, DOI 10.1139/Y02-038
   Schupp M, 2004, CIRCULATION, V109, P2054, DOI 10.1161/01.CIR.0000127955.36250.65
   Shiuchi T, 2004, HYPERTENSION, V43, P1003, DOI 10.1161/01.HYP.0000125142.41703.64
   Skurk T, 2004, ARTERIOSCL THROM VAS, V24, P1199, DOI 10.1161/01.ATV.0000131266.38312.2e
   Tomono Y, 2008, AM J HYPERTENS, V21, P206, DOI 10.1038/ajh.2007.50
   Tsuchida A, 2005, J PHARMACOL SCI, V97, P164, DOI 10.1254/jphs.FMJ04008X2
   Tsuchiya K, 2006, AM J PHYSIOL-ENDOC M, V291, pE771, DOI 10.1152/ajpendo.00560.2005
   Urbanet R, 2010, J CLIN ENDOCR METAB, V95, P4037, DOI 10.1210/jc.2010-0097
   Uysal KT, 1997, NATURE, V389, P610, DOI 10.1038/39335
   Wada T, 2009, ENDOCRINOLOGY, V150, P1662, DOI 10.1210/en.2008-1018
   Weir MR, 2007, CLIN THER, V29, P1803, DOI 10.1016/j.clinthera.2007.09.019
   Yu CL, 2002, J BIOL CHEM, V277, P50230, DOI 10.1074/jbc.M200958200
   Yuan MS, 2001, SCIENCE, V293, P1673, DOI 10.1126/science.1061620
   Yusuf S, 2000, NEW ENGL J MED, V342, P145
   Yvan-Charvet L, 2005, DIABETES, V54, P991, DOI 10.2337/diabetes.54.4.991
   Yvan-Charvet L, 2011, KIDNEY INT, V79, P162, DOI 10.1038/ki.2010.391
   Zimmet P, 2005, J ATHEROSCLER THROMB, V12, P295, DOI 10.5551/jat.12.295
NR 74
TC 37
Z9 40
U1 1
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD SEP 25
PY 2013
VL 378
IS 1-2
SI SI
BP 23
EP 28
DI 10.1016/j.mce.2012.03.005
PG 6
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 242CC
UT WOS:000326214000003
PM 22465098
DA 2025-06-11
ER

PT J
AU Hashemi, M
   Kordi-Tamandani, DM
   Sharifi, N
   Moazeni-Roodi, A
   Kaykhaei, MA
   Narouie, B
   Torkmanzehi, A
AF Hashemi, Mohammad
   Kordi-Tamandani, Dor Mohammad
   Sharifi, Nooshin
   Moazeni-Roodi, Abdolkarim
   Kaykhaei, Mahmoud-Ali
   Narouie, Behzad
   Torkmanzehi, Adam
TI Serum paraoxonase and arylesterase activities in metabolic syndrome in
   Zahedan, southeast Iran
SO EUROPEAN JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; RHEUMATOID-ARTHRITIS; DIABETES-MELLITUS;
   OXIDATIVE STRESS; POLYMORPHISM; CORONARY; RISK; GENE
AB Objective: Paraoxonase (PON) is associated with high-density lipoprotein and protects serum lipid from oxidation. The aim of this study was to determine serum PON, arylesterase (ARE) activities, and total antioxidant capacity (TAC) in metabolic syndrome (MES).
   Methods: This case-control study was performed on 106 patients with MES and 231 healthy subjects. Serum PON and ARE activities were determined spectrophotometrically. TAC was determined using ferric reducing ability of plasma assay.
   Results: The results showed that serum PON activity was significantly lower in patients with MES (69.62 +/- 59.86 IU/l) than healthy subjects (91.64 +/- 77.45 IU/l) (P<0.05). The serum ARE activity in MES and normal subjects were 45.23 +/- 23.24 and 65.69 +/- 31.10 kU/l respectively. The ARE activity was significantly lower in patients with MES than normal subjects (P<0.0001). No significant differences were observed between MES and normal subjects regarding TAC.
   Conclusion: The lower PON and ARE activities in MES may be considered an independent risk factor for cardiovascular disease, which remains to be cleared. European Journal of Endocrinology 164 219-222
C1 [Hashemi, Mohammad] Zahedan Univ Med Sci, Dept Clin Biochem, Sch Med, Zahedan 9816743175, Iran.
   [Kordi-Tamandani, Dor Mohammad; Sharifi, Nooshin; Torkmanzehi, Adam] Univ Sistan & Baluchestan, Dept Biol, Fac Sci, Zahedan 98155987, Iran.
   [Moazeni-Roodi, Abdolkarim] Zahedan Univ Med Sci, Res Ctr Infect Dis & Trop Med, Zahedan 9816743175, Iran.
   [Kaykhaei, Mahmoud-Ali; Narouie, Behzad] Zahedan Univ Med Sci, Dept Internal Med, Sch Med, Zahedan 9816743175, Iran.
C3 Zahedan University of Medical Sciences; University of Sistan &
   Baluchestan; Zahedan University of Medical Sciences; Zahedan University
   of Medical Sciences
RP Hashemi, M (corresponding author), Zahedan Univ Med Sci, Dept Clin Biochem, Sch Med, Zahedan 9816743175, Iran.
EM mhd.hashemi@gmail.com
RI Mohammad, Dor/AGT-2048-2022; narouie, behzad/ABC-3389-2020; Kaykhaei,
   Mahmoud Ali/F-8801-2011; hashemi, Mohammad/H-2446-2016; Moazeni-roodi,
   Abdolkarim/F-9845-2017
OI Kordi Tamanadani, Dor Mohammad/0000-0002-4358-4785; Kaykhaei, Mahmoud
   Ali/0000-0003-2994-4243; hashemi, Mohammad/0000-0002-6074-7101;
   Moazeni-roodi, Abdolkarim/0000-0002-3561-0592
FU Zahedan University of Medical Sciences
FX This project was supported by a research grant from Zahedan University
   of Medical Sciences.
CR ABBOTT CA, 1995, ARTERIOSCL THROM VAS, V15, P1812, DOI 10.1161/01.ATV.15.11.1812
   Aviram M, 2000, CIRCULATION, V101, P2510, DOI 10.1161/01.CIR.101.21.2510
   Aviram M, 2000, AM J CLIN NUTR, V71, P1062
   Garin MCB, 1997, J CLIN INVEST, V99, P62, DOI 10.1172/JCI119134
   Hashemi M, 2010, GENET MOL RES, V9, P1735, DOI 10.4238/vol9-3gmr893
   Hashemi M, 2010, GENET MOL RES, V9, P333, DOI 10.4238/vol9-1gmr728
   Hashemi M, 2010, J EUR ACAD DERMATOL, V24, P329, DOI 10.1111/j.1468-3083.2009.03416.x
   Jayakumari N, 2009, J CLIN BIOCHEM NUTR, V45, P278, DOI 10.3164/jcbn.08-255
   Knight JA, 1998, ANN CLIN LAB SCI, V28, P331
   Leviev I, 2000, ARTERIOSCL THROM VAS, V20, P516, DOI 10.1161/01.ATV.20.2.516
   López-Flores I, 2009, TOXICOL LETT, V188, P84, DOI 10.1016/j.toxlet.2009.03.010
   MACKNESS MI, 1991, FEBS LETT, V286, P152, DOI 10.1016/0014-5793(91)80962-3
   MACKNESS MI, 1991, ATHEROSCLEROSIS, V86, P193, DOI 10.1016/0021-9150(91)90215-O
   McNeill AM, 2005, DIABETES CARE, V28, P385, DOI 10.2337/diacare.28.2.385
   Mohamadin Ahmed M, 2010, Pathophysiology, V17, P189, DOI 10.1016/j.pathophys.2009.11.004
   NADERI M, PATHOPHYSIO IN PRESS
   Phuntuwate W, 2005, J HUM GENET, V50, P293, DOI 10.1007/s10038-005-0255-7
   Sattar N, 2003, CIRCULATION, V108, P414, DOI 10.1161/01.CIR.0000080897.52664.94
   Sentí M, 2003, J CLIN ENDOCR METAB, V88, P5422, DOI 10.1210/jc.2003-030648
   Tabur S, 2010, EUR J ENDOCRINOL, V162, P535, DOI 10.1530/EJE-09-0732
   van der Gaag MS, 1999, ATHEROSCLEROSIS, V147, P405, DOI 10.1016/S0021-9150(99)00243-9
   Varga É, 2009, DIS MARKERS, V26, P141, DOI [10.1155/2009/819862, 10.3233/DMA-2009-0624]
   Wang JJ, 2007, EUR HEART J, V28, P857, DOI 10.1093/eurheartj/ehl524
   Young IS, 2001, J CLIN PATHOL, V54, P176, DOI 10.1136/jcp.54.3.176
   2001, JAMA-J AM MED ASSOC, V285, P2486, DOI DOI 10.1001/JAMA.285.19.2486
NR 25
TC 17
Z9 19
U1 0
U2 5
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0804-4643
J9 EUR J ENDOCRINOL
JI Eur. J. Endocrinol.
PD FEB
PY 2011
VL 164
IS 2
BP 219
EP 222
DI 10.1530/EJE-10-0881
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 707UY
UT WOS:000286315500009
PM 21059866
DA 2025-06-11
ER

PT J
AU Grant, P
   Jackson, G
   Baig, I
   Quin, J
AF Grant, Paul
   Jackson, Graham
   Baig, Irfan
   Quin, John
TI Erectile dysfunction in general medicine
SO CLINICAL MEDICINE
LA English
DT Article
ID TESTOSTERONE CONCENTRATIONS; RISK; MEN
AB Erectile dysfunction (ED) affects millions of men worldwide with implications that go far beyond sexual activity. ED is now recognised as an early marker of cardiovascular disease, diabetes mellitus (DM) and depression. The risk factors that are associated with ED (sedentary lifestyle, obesity, smoking, hypercholesterolaemia and the metabolic syndrome) are very similar to those for cardiovascular disease (CVD). Arguably, the awareness of ED as a symptomatic entity in the post-Viagra (TM) age is on the rise. Nevertheless, ED is commonly missed when evaluating patients in the hospital setting, either because of lack of consideration or awareness, or through simple embarrassment (of both clinician and patient). This article provides an overview of the aetiology, assessment and importance of ED and hopes to promote its consideration in day-to-day clinical practice.
C1 [Grant, Paul] Maidstone & Tunbridge Wells Hosp Trust, Maidstone, Kent, England.
   [Jackson, Graham] London Bridge Hosp, London, England.
   [Baig, Irfan; Quin, John] Royal Sussex Cty Hosp, Brighton, E Sussex, England.
C3 University of Brighton
RP Grant, P (corresponding author), Maidstone Hlth Author, Dept Endocrinol & Diabet, Hermitage Lane, Maidstone ME16 9QQ, Kent, England.
EM drpaul.grant@doctors.org.uk
CR Bacon CG, 2000, J UROLOGY, V176, P217
   Beaudet A, 2010, J MENS HEALTH, V7, P1875
   Böhm M, 2010, CIRCULATION, V121, P1439, DOI 10.1161/CIRCULATIONAHA.109.864199
   Brüning JC, 2000, SCIENCE, V289, P2122, DOI 10.1126/science.289.5487.2122
   Corona G, 2011, INT J ANDROL, V34, P528, DOI 10.1111/j.1365-2605.2010.01117.x
   Dhindsa S, 2010, DIABETES CARE, V33, P1186, DOI 10.2337/dc09-1649
   Dong JY, 2011, J AM COLL CARDIOL, V58, P1378, DOI 10.1016/j.jacc.2011.06.024
   Esposito K, 2004, JAMA-J AM MED ASSOC, V291, P2978, DOI 10.1001/jama.291.24.2978
   Feldman HA, 2000, PREV MED, V30, P328, DOI 10.1006/pmed.2000.0643
   Ghanem HM, 2013, J SEX MED, V10, P108, DOI 10.1111/j.1743-6109.2012.02734.x
   Grant PS, 2009, ACTA DIABETOL, V46, P285, DOI 10.1007/s00592-008-0084-1
   Gupta BP, 2011, ARCH INTERN MED, V171, P1797, DOI 10.1001/archinternmed.2011.440
   Hackett G, 2011, J SEX MED, V8, P1743
   Ilsley C, 2012, ERECTILE DYSFUNCTION
   Inman BA, 2009, MAYO CLIN PROC, V84, P108, DOI 10.4065/84.2.108
   Jackson G, 2010, INT J CLIN PRACT, V64, P848, DOI 10.1111/j.1742-1241.2010.02410.x
   Jackson Graham, 2007, Curr Urol Rep, V8, P463, DOI 10.1007/s11934-007-0049-x
   Jackson G, 2012, MATURITAS, V72, P263, DOI 10.1016/j.maturitas.2012.03.012
   Jones TH, 2011, DIABETES CARE, V34, P828, DOI 10.2337/dc10-1233
   Karelis AD, 2004, J CLIN ENDOCR METAB, V89, P2569, DOI 10.1210/jc.2004-0165
   Knoblovits P, 2011, ENDO REV, V32
   Landau D, 2012, CLIN ENDOCRINOL, V76, P179, DOI 10.1111/j.1365-2265.2011.04233.x
   Montorsi P, 2003, EUR UROL, V44, P352, DOI 10.1016/S0302-2838(03)00307-5
   O'Boyle J, 2012, J SEX MED, V9, P16
   O'Donnell AB, 2004, EXP GERONTOL, V39, P975, DOI 10.1016/j.exger.2004.03.023
   Schwartz BG, 2011, CIRCULATION, V123, P98, DOI 10.1161/CIRCULATIONAHA.110.984179
   Seidman S N, 2000, Curr Psychiatry Rep, V2, P201, DOI 10.1007/s11920-996-0008-0
   Shiri R, 2007, J UROLOGY, V177, P669, DOI 10.1016/j.juro.2006.09.030
   Tomar R, 2006, DIABETES CARE, V29, P1120, DOI 10.2337/dc06-0197
NR 29
TC 23
Z9 26
U1 0
U2 11
PU ROY COLL PHYS LONDON EDITORIAL OFFICE
PI LONDON
PA 11 ST ANDREWS PLACE REGENTS PARK, LONDON NW1 4LE, ENGLAND
SN 1470-2118
EI 1473-4893
J9 CLIN MED
JI Clin. Med.
PD APR
PY 2013
VL 13
IS 2
BP 136
EP 140
DI 10.7861/clinmedicine.13-2-136
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 122JQ
UT WOS:000317314800005
PM 23681859
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Harrell, CS
   Zainaldin, C
   McFarlane, D
   Hyer, MM
   Stein, D
   Sayeed, I
   Neigh, GN
AF Harrell, C. S.
   Zainaldin, C.
   McFarlane, D.
   Hyer, M. M.
   Stein, D.
   Sayeed, I.
   Neigh, G. N.
TI High-fructose diet during adolescent development increases
   neuroinflammation and depressive-like behavior without exacerbating
   outcomes after stroke
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Affective-like behavior; Complement; Fructose; Adolescence; Stroke
ID FEMALE CALIFORNIA MICE; ISCHEMIC-STROKE; OXIDATIVE STRESS; ENDURING
   CONSEQUENCES; FUNCTIONAL RECOVERY; COMPLEMENT CASCADE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; ANXIETY-LIKE; AGED RATS
AB Diseases, disorders, and insults of aging are frequently studied in otherwise healthy animal models despite rampant co-morbidities and exposures among the human population. Stressor exposures can increase neuroinflammation and augment the inflammatory response following a challenge. The impact of dietary exposure on baseline neural function and behavior has gained attention; in particular, a diet high in fructose can increase activation of the hypothalamic-pituitary-adrenal axis and alter behavior. The current study considers the implications of a diet high in fructose for neuroinflammation and outcomes following the cerebrovascular challenge of stroke. Ischemic injury may come as a "second hit" to pre-existing metabolic pathology, exacerbating inflammatory and behavioral sequelae. This study assesses the neuroinflammatory consequences of a pea adolescent high-fructose diet model and assesses the impact of diet-induced metabolic dysfunction on behavioral and neuropathological outcomes after middle cerebral artery occlusion. We demonstrate that consumption of a high-fructose diet initiated during adolescent development increases brain complement expression, elevates plasma TNF alpha and serum corticosterone, and promotes depressive-like behavior. Despite these adverse effects of diet exposure, pen-adolescent fructose consumption did not exacerbate neurological behaviors or lesion volume after middle cerebral artery occlusion.
C1 [Harrell, C. S.; Zainaldin, C.; McFarlane, D.; Neigh, G. N.] Emory Univ, Sch Med, Dept Physiol, Atlanta, GA 30322 USA.
   [Stein, D.; Sayeed, I.] Emory Univ, Sch Med, Dept Emergency Med, Atlanta, GA 30322 USA.
   [Hyer, M. M.; Neigh, G. N.] Virginia Commonwealth Univ, Dept Anat & Neurobiol, 1101 East Marshall St, Richmond, VA 23298 USA.
C3 Emory University; Emory University; Virginia Commonwealth University
RP Neigh, GN (corresponding author), Virginia Commonwealth Univ, Dept Anat & Neurobiol, 1101 East Marshall St, Richmond, VA 23298 USA.
EM gretchen.mccandless@vcuhealth.org
RI Neigh, Gretchen/AAW-5691-2020; Stein, Donald/AAJ-5139-2020; Neigh,
   Gretchen/G-3662-2011
OI McFarlane, Danielle/0009-0008-3149-7781; Neigh,
   Gretchen/0000-0003-0955-9161; Harrell Shreckengost, Constance
   S./0000-0001-5229-0140; Hyer, Molly/0000-0001-7687-2030
FU National Institutes of Health [R21MH091321-01]; American Heart
   Association Predoctoral Fellowship [14PRE18910002]; Virginia
   Commonwealth Department of Anatomy and Neurobiology; National Institute
   of Health Institutional Research and Academic Career Development Award
   [K12GM093857]; American Heart Association (AHA) [14PRE18910002] Funding
   Source: American Heart Association (AHA)
FX The authors would like to acknowledge Bushra Wali, PhD, Christina
   Nemeth, PhD, Sean Kelly, and Leah Vaughan for their technical
   assistance. Funding for the studies in this manuscript was provided by
   the National Institutes of Health R21MH091321-01 (GNN), the American
   Heart Association Predoctoral Fellowship (14PRE18910002; CSH), Virginia
   Commonwealth Department of Anatomy and Neurobiology (GNN), and the
   National Institute of Health Institutional Research and Academic Career
   Development Award (K12GM093857; MMH).
CR Abbott NJ, 2010, NEUROBIOL DIS, V37, P13, DOI 10.1016/j.nbd.2009.07.030
   Alexander JJ, 2008, J NEUROCHEM, V107, P1169, DOI 10.1111/j.1471-4159.2008.05668.x
   Alexopoulos GS, 2006, BIOL PSYCHIAT, V60, P1304, DOI 10.1016/j.biopsych.2006.09.006
   Anderson RJ, 2001, DIABETES CARE, V24, P1069, DOI 10.2337/diacare.24.6.1069
   [Anonymous], aminothiolcompoundonradiationinducedintestinalinjuryJ.Int
   Atif F, 2013, NEUROPHARMACOLOGY, V67, P78, DOI 10.1016/j.neuropharm.2012.10.004
   Bekhbat M, 2018, BRAIN BEHAV IMMUN, V67, P1, DOI 10.1016/j.bbi.2017.02.006
   Bilbo SD, 2010, FASEB J, V24, P2104, DOI 10.1096/fj.09-144014
   Bonifati DM, 2007, MOL IMMUNOL, V44, P999, DOI 10.1016/j.molimm.2006.03.007
   Boyko M, 2013, COGN AFFECT BEHAV NE, V13, P847, DOI 10.3758/s13415-013-0177-3
   BRINDLEY DN, 1981, BIOCHEM J, V200, P275, DOI 10.1042/bj2000275
   Catena C, 2003, AM J HYPERTENS, V16, P973, DOI 10.1016/S0895-7061(03)01002-1
   Cigliano L, 2018, MOL NEUROBIOL, V55, P2869, DOI 10.1007/s12035-017-0518-2
   Collino M, 2010, BRIT J PHARMACOL, V160, P1892, DOI 10.1111/j.1476-5381.2010.00671.x
   D'Ambrosio AL, 2001, MOL MED, V7, P367, DOI 10.1007/BF03402183
   Dallman MF, 1999, ENDOCRINE, V11, P111, DOI 10.1385/ENDO:11:2:111
   DeVries AC, 2001, NEUROSCI BIOBEHAV R, V25, P325, DOI 10.1016/S0149-7634(01)00017-3
   DiNapoli VA, 2010, NEUROSCIENCE, V170, P633, DOI 10.1016/j.neuroscience.2010.07.011
   DiNapoli VA, 2008, NEUROBIOL AGING, V29, P753, DOI 10.1016/j.neurobiolaging.2006.12.007
   Djordjevic A, 2015, NUTR NEUROSCI, V18, P66, DOI 10.1179/1476830513Y.0000000098
   Edgar R, 2002, NUCLEIC ACIDS RES, V30, P207, DOI 10.1093/nar/30.1.207
   Estanislau C, 2013, NEUROSCI RES, V77, P187, DOI 10.1016/j.neures.2013.09.012
   FILE SE, 1978, BRIT J PHARMACOL, V62, P19, DOI 10.1111/j.1476-5381.1978.tb07001.x
   Gainotti G, 2001, J NEUROL NEUROSUR PS, V71, P258, DOI 10.1136/jnnp.71.2.258
   Ghose SS, 2005, MED CARE, V43, P1259, DOI 10.1097/01.mlr.0000185711.50480.13
   Glushakova O, 2008, J AM SOC NEPHROL, V19, P1712, DOI 10.1681/ASN.2007121304
   Hackett ML, 2005, STROKE, V36, P1330, DOI 10.1161/01.STR.0000165928.19135.35
   Harrell CS, 2016, PHYSIOL BEHAV, V166, P43, DOI 10.1016/j.physbeh.2015.10.009
   Harrell CS, 2015, PSYCHONEUROENDOCRINO, V62, P252, DOI 10.1016/j.psyneuen.2015.08.025
   House A, 2001, STROKE, V32, P696, DOI 10.1161/01.STR.32.3.696
   Huang J, 2006, SURG NEUROL, V66, P232, DOI 10.1016/j.surneu.2005.12.028
   HWANG IS, 1987, HYPERTENSION, V10, P512, DOI 10.1161/01.HYP.10.5.512
   Kalidindi A, 2017, PHYSIOL BEHAV, V172, P12, DOI 10.1016/j.physbeh.2016.07.007
   Kalueff AV, 2016, NAT REV NEUROSCI, V17, P45, DOI 10.1038/nrn.2015.8
   KasimKarakas SE, 1996, J LAB CLIN MED, V128, P208, DOI 10.1016/S0022-2143(96)90013-X
   Kawasaki T, 2009, J NUTR, V139, P2067, DOI 10.3945/jn.109.105858
   Kelany ME, 2017, CAN J PHYSIOL PHARM, V95, P140, DOI 10.1139/cjpp-2016-0152
   Kinote A, 2012, ENDOCRINOLOGY, V153, P3633, DOI 10.1210/en.2012-1341
   Kronenberg G, 2014, BRIT J PHARMACOL, V171, P4673, DOI 10.1111/bph.12775
   Lamers F, 2013, MOL PSYCHIATR, V18, P692, DOI 10.1038/mp.2012.144
   Levinson W., 2012, Review of Medical Microbiology and Immunology
   Liu JL, 2014, PROG NEUROBIOL, V115, P138, DOI 10.1016/j.pneurobio.2013.11.004
   Marissal-Arvy N, 2014, BRIT J NUTR, V111, P1190, DOI 10.1017/S0007114513003577
   Marty N, 2007, PHYSIOLOGY, V22, P241, DOI 10.1152/physiol.00010.2007
   McCormick CM, 2007, PHARMACOL BIOCHEM BE, V86, P220, DOI 10.1016/j.pbb.2006.07.012
   McEwen BS, 2004, EUR J PHARMACOL, V490, P13, DOI 10.1016/j.ejphar.2004.02.041
   McEwen BS, 1999, ANNU REV NEUROSCI, V22, P105, DOI 10.1146/annurev.neuro.22.1.105
   Nadeau K, 2008, ENDOCR RES, V33, P35, DOI 10.1080/07435800802080138
   Neigh GN, 2017, PHYSIOL BEHAV, V172, P24, DOI 10.1016/j.physbeh.2016.07.009
   Neigh GN, 2010, J CEREBR BLOOD F MET, V30, P1100, DOI 10.1038/jcbfm.2010.46
   Nemeth CL, 2016, BEHAV BRAIN RES, V303, P160, DOI 10.1016/j.bbr.2016.01.057
   Nemeth CL, 2015, PSYCHONEUROENDOCRINO, V54, P71, DOI 10.1016/j.psyneuen.2015.01.023
   Nemeth CL, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0108399
   Nemeth CL, 2012, BEHAV BRAIN RES, V234, P259, DOI 10.1016/j.bbr.2012.06.014
   Nyby MD, 2007, HYPERTENS RES, V30, P451, DOI 10.1291/hypres.30.451
   Ogden CL, 2014, JAMA-J AM MED ASSOC, V311, P806, DOI 10.1001/jama.2014.732
   PELLOW S, 1985, J NEUROSCI METH, V14, P149, DOI 10.1016/0165-0270(85)90031-7
   PORSOLT RD, 1977, NATURE, V266, P730, DOI 10.1038/266730a0
   Prut L, 2003, EUR J PHARMACOL, V463, P3, DOI 10.1016/S0014-2999(03)01272-X
   Rutledge AC, 2007, NUTR REV, V65, pS13, DOI 10.1301/nr.2007.jun.S13-S23
   Sakhai SA, 2013, PHYSIOL BEHAV, V120, P156, DOI 10.1016/j.physbeh.2013.08.003
   Silva AL, 2010, BEHAV BRAIN RES, V208, P528, DOI 10.1016/j.bbr.2009.12.038
   Spear LP, 2000, NEUROSCI BIOBEHAV R, V24, P417, DOI 10.1016/S0149-7634(00)00014-2
   Steinman MQ, 2011, EUR J NEUROSCI, V33, P361, DOI 10.1111/j.1460-9568.2010.07528.x
   Tanislav C, 2015, NEUROEPIDEMIOLOGY, V44, P30, DOI 10.1159/000371389
   Whishaw I.Q, 2004, BEHAV LAB RAT HDB TE, P520
   Whyte EM, 2004, J AM GERIATR SOC, V52, P774, DOI 10.1111/j.1532-5415.2004.52217.x
   Winter B, 2005, BIOL PSYCHIAT, V57, P1166, DOI 10.1016/j.biopsych.2005.02.010
   Yousuf S, 2015, RESTOR NEUROL NEUROS, V33, P251, DOI 10.3233/RNN-140450
   Yousuf S, 2014, PSYCHOPHARMACOLOGY, V231, P3313, DOI 10.1007/s00213-014-3556-8
NR 70
TC 24
Z9 26
U1 0
U2 8
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD OCT
PY 2018
VL 73
BP 340
EP 351
DI 10.1016/j.bbi.2018.05.018
PG 12
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA GU6QO
UT WOS:000445440900036
PM 29787857
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Han, KM
   Kim, MS
   Kim, A
   Paik, JW
   Lee, J
   Ham, BJ
AF Han, Kyu-Man
   Kim, Mm Sun
   Kim, Aram
   Paik, Jong-Woo
   Lee, Juneyoung
   Ham, Byung-Joo
TI Chronic medical conditions and metabolic syndrome as risk factors for
   incidence of major depressive disorder: A longitudinal study based on
   4.7 million adults in South Korea
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Major depressive disorder; Metabolic syndrome; Physical illness;
   Longitudinal; Risk factors
ID MIDDLE-AGED ADULTS; CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY;
   MENTAL-DISORDERS; MOOD DISORDERS; BLOOD-PRESSURE; SYMPTOMS; ASSOCIATION;
   ANXIETY; PREVALENCE
AB Background: The assessment of comorbid physical illness and metabolic or cardiovascular risk factors as potential risk factors for onset of major depressive disorder (MDD) is crucial. We aimed to investigate potential risk factors for the development of MDD among individuals with chronic medical conditions and metabolic and behavioral risk factors using a large population-based retrospective cohort from the data of the National Health Insurance Service (NHIS) in South Korea.
   Methods: The population-based retrospective cohort included data from 2,370,815 adults (age >= 20 years) diagnosed with MDD between January 1, 2010, and December 31, 2016 and age- and gender-matched 2,370,815 healthy controls obtained from the claims data of the NHIS. The data of the regular health checkup provided by the NHIS were also included (age >= 40 years). Logistic regression analyses were performed to investigate the potential risk factors for the incidence of MDD.
   Results: Chronic medical conditions such as Parkinson's disease (odds ratio [OR] = 7.808, 95% confidence interval [CI] = 7.517-8.11), epilepsy (OR = 6.119, 95% CI = 6.019-6.22), multiple sclerosis (OR = 5.532, 95% CI = 4.976-6.151), Huntington's disease (OR = 5.387, 95% CI = 3.258-8.909), migraine (OR = 4.374, 95% CI = 4.341-4.408), stroke (OR = 4.074, 95% CI = 4.032-4.117), and cancer; metabolic syndrome (OR = 1.049, 95% CI = 1.041-1.057) and several of its components including central obesity, elevated fasting blood glucose and triglyceride levels, and reduced high-density lipoprotein level; and cigarette smoking, frequent alcohol consumption, and low physical activity are potential risk factors for the development of MDD.
   Conclusion: Our results may support previous evidence on the association between physical conditions and the incidence of MDD as reported by individual population-based studies with modest sample sizes.
C1 [Han, Kyu-Man; Ham, Byung-Joo] Korea Univ, Coll Med, Dept Psychiat, Anam Hosp, 73 Inchon Ro, Seoul 02841, South Korea.
   [Kim, Mm Sun; Lee, Juneyoung] Korea Univ, Coll Med, Dept Biostat, Seoul, South Korea.
   [Kim, Aram; Ham, Byung-Joo] Korea Univ, Coll Med, Dept Biomed Sci, Seoul, South Korea.
   [Paik, Jong-Woo] Kyung Hee Univ, Coll Med, Dept Psychiat, Seoul, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine); Korea
   University; Korea University Medicine (KU Medicine); Korea University;
   Korea University Medicine (KU Medicine); Kyung Hee University
RP Ham, BJ (corresponding author), Korea Univ, Coll Med, Dept Psychiat, Anam Hosp, 73 Inchon Ro, Seoul 02841, South Korea.
EM hambj@korea.ac.kr
RI Ham, Byung-Joo/S-9982-2019; LEE, HYUN/D-6482-2016; PAIK,
   JONG-WOO/C-2177-2016
OI Han, Kyu-Man/0000-0002-1982-4216; Lee, Juneyoung/0000-0001-8073-9304;
   Ham, Byung Joo/0000-0002-0108-2058
FU Bio & Medical Technology Development Program of the National Research
   Foundation (NRF) - Ministry of Science, ICT & Future Planning
   [NRF-2016M3A9A7916996]; Research Program To Solve Social Issues of the
   National Research Foundation of Korea (NRF) - Ministry of Science and
   ICT [NRF-2017R1A2B4002090]
FX This research was supported by the Bio & Medical Technology Development
   Program of the National Research Foundation (NRF) funded by the Ministry
   of Science, ICT & Future Planning (NRF-2016M3A9A7916996) and the
   Research Program To Solve Social Issues of the National Research
   Foundation of Korea (NRF) funded by the Ministry of Science and ICT
   (NRF-2017R1A2B4002090). The funding agency had no role in the study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
CR Äijänseppä S, 2002, INT J GERIATR PSYCH, V17, P629, DOI 10.1002/gps.666
   Akbaraly TN, 2009, DIABETES CARE, V32, P499, DOI 10.2337/dc08-1358
   Akizuki N, 2016, JPN J CLIN ONCOL, V46, P71, DOI 10.1093/jjco/hyv169
   Almeida OP, 2009, AM J GERIAT PSYCHIAT, V17, P889, DOI 10.1097/JGP.0b013e3181b047e3
   Atlantis E, 2013, CHEST, V144, P766, DOI 10.1378/chest.12-1911
   Bautovich A, 2014, AUST NZ J PSYCHIAT, V48, P530, DOI 10.1177/0004867414528589
   Berk M, 2013, ACTA PSYCHIAT SCAND, V127, P38, DOI 10.1111/acps.12124
   Boden JM, 2011, ADDICTION, V106, P906, DOI 10.1111/j.1360-0443.2010.03351.x
   Boeschoten RE, 2017, J NEUROL SCI, V372, P331, DOI 10.1016/j.jns.2016.11.067
   Briggs R, 2017, AGE AGEING, V46, P648, DOI 10.1093/ageing/afx033
   Brook DW, 2002, ARCH GEN PSYCHIAT, V59, P1039, DOI 10.1001/archpsyc.59.11.1039
   Brown WJ, 2005, AM J PREV MED, V29, P265, DOI 10.1016/j.amepre.2005.06.009
   Caldwell TM, 2002, ADDICTION, V97, P583, DOI 10.1046/j.1360-0443.2002.00092.x
   Carney RM, 2008, AM J MED, V121, P20, DOI 10.1016/j.amjmed.2008.09.010
   Carpenter KM, 2000, AM J PUBLIC HEALTH, V90, P251, DOI 10.2105/AJPH.90.2.251
   Choi HG, 2019, OTOLARYNG HEAD NECK, V160, P239, DOI 10.1177/0194599818802190
   Chun S. Y, 2018, EUR J PUBLIC HLTH
   Claassen L, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-248
   Dalton SO, 2009, J CLIN ONCOL, V27, P1440, DOI 10.1200/JCO.2008.20.5526
   de Wit LM, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-14
   Epping EA, 2011, NEURODEGENER DIS MAN, V1, P407, DOI 10.2217/NMT.11.45
   Galper DI, 2006, MED SCI SPORT EXER, V38, P173, DOI 10.1249/01.mss.0000180883.32116.28
   Gould CE, 2013, INT J GERIATR PSYCH, V28, P1045, DOI 10.1002/gps.3926
   Gracely RH, 2012, PAIN RES TREAT, V2012, DOI 10.1155/2012/486590
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Huang CQ, 2010, AGEING RES REV, V9, P131, DOI 10.1016/j.arr.2009.05.005
   Jette N, 2008, HEADACHE, V48, P501, DOI 10.1111/j.1526-4610.2007.00993.x
   Johnson EO, 2006, NICOTINE TOB RES, V8, P257, DOI 10.1080/14622200600576644
   Kessler RC, 2006, AM J PSYCHIAT, V163, P1561, DOI 10.1176/appi.ajp.163.9.1561
   Kim M, 2018, EPILEPSY BEHAV, V84, P56, DOI 10.1016/j.yebeh.2018.04.015
   Klungsoyr O, 2006, AM J EPIDEMIOL, V163, P421, DOI 10.1093/aje/kwj058
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178, DOI 10.4088/JCP.v69n0202
   Kupfer DJ, 2012, LANCET, V379, P1045, DOI 10.1016/S0140-6736(11)60602-8
   Kuwahara K, 2018, J EPIDEMIOL, V28, P94, DOI 10.2188/jea.JE20170009
   Lee JH, 2017, EUR PSYCHIAT, V45, P72, DOI 10.1016/j.eurpsy.2017.05.025
   Lee J, 2017, INT J EPIDEMIOL, V46, DOI 10.1093/ije/dyv319
   Lin EHB, 2008, J PSYCHOSOM RES, V65, P571, DOI 10.1016/j.jpsychores.2008.06.007
   Lloyd-Jones DM, 2004, JAMA-J AM MED ASSOC, V291, P2204, DOI 10.1001/jama.291.18.2204
   Marazziti D, 2014, CNS SPECTRUMS, V19, P293, DOI 10.1017/S1092852913000667
   Marsh L, 2013, CURR NEUROL NEUROSCI, V13, DOI 10.1007/s11910-013-0409-5
   Massie Mary Jane, 2004, J Natl Cancer Inst Monogr, P57
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Mitchell AJ, 2017, GEN HOSP PSYCHIAT, V47, P48, DOI 10.1016/j.genhosppsych.2017.04.001
   Modgill G, 2012, HEADACHE, V52, P422, DOI 10.1111/j.1526-4610.2011.02036.x
   Moussavi S, 2007, LANCET, V370, P851, DOI 10.1016/S0140-6736(07)61415-9
   Murabito JM, 2005, JAMA-J AM MED ASSOC, V294, P3117, DOI 10.1001/jama.294.24.3117
   Noh JW, 2015, BMC PUBLIC HEALTH, V15, DOI 10.1186/s12889-015-1663-z
   Nouwen A, 2010, DIABETOLOGIA, V53, P2480, DOI 10.1007/s00125-010-1874-x
   O'Connor PJ, 2009, ANN FAM MED, V7, P328, DOI 10.1370/afm.964
   Olver JS, 2013, MED J AUSTRALIA, V199, P9, DOI 10.5694/mjao12.10597
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Papakostas GI, 2004, GEN HOSP PSYCHIAT, V26, P13, DOI 10.1016/j.genhosppsych.2003.07.004
   Park SJ, 2016, J AFFECT DISORDERS, V205, P393, DOI 10.1016/j.jad.2016.08.022
   Partonen T, 1999, BRIT J PSYCHIAT, V175, P259, DOI 10.1192/bjp.175.3.259
   Pasco JA, 2008, BRIT J PSYCHIAT, V193, P322, DOI 10.1192/bjp.bp.107.046706
   Paulsen JS, 2005, J NEUROPSYCH CLIN N, V17, P496, DOI 10.1176/appi.neuropsych.17.4.496
   Prince MJ, 1998, PSYCHOL MED, V28, P337, DOI 10.1017/S0033291797006478
   Pulkki-Råback L, 2009, HEALTH PSYCHOL, V28, P108, DOI 10.1037/a0012646
   Rasic DT, 2008, PSYCHO-ONCOL, V17, P660, DOI 10.1002/pon.1292
   Read JR, 2017, J AFFECT DISORDERS, V221, P36, DOI 10.1016/j.jad.2017.06.009
   Reijnders JSAM, 2008, MOVEMENT DISORD, V23, P183, DOI 10.1002/mds.21803
   Rhee EJ, 2018, J CLIN HYPERTENS, V20, P1417, DOI 10.1111/jch.13389
   Robinson RG, 2016, AM J PSYCHIAT, V173, P221, DOI 10.1176/appi.ajp.2015.15030363
   Rodgers B, 2000, PSYCHOL MED, V30, P421, DOI 10.1017/S0033291799001865
   Rottmann N, 2016, J CANCER SURVIV, V10, P915, DOI 10.1007/s11764-016-0538-3
   Scott AJ, 2017, EPILEPSIA, V58, P973, DOI 10.1111/epi.13769
   Seong SC, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2017-016640
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Stranges S, 2006, ADDICTION, V101, P1265, DOI 10.1111/j.1360-0443.2006.01517.x
   Sullivan DR, 2016, J CLIN ONCOL, V34, P3984, DOI 10.1200/JCO.2016.66.8459
   Tan Louis C S, 2012, Parkinsonism Relat Disord, V18 Suppl 1, pS74, DOI 10.1016/S1353-8020(11)70024-4
   Taylor WD, 2013, MOL PSYCHIATR, V18, P963, DOI 10.1038/mp.2013.20
   Tedders SH, 2011, J AFFECT DISORDERS, V135, P115, DOI 10.1016/j.jad.2011.06.045
   Thombs BD, 2006, J GEN INTERN MED, V21, P30, DOI 10.1111/j.1525-1497.2005.00269.x
   Thomsen AF, 2005, THYROID, V15, P700, DOI 10.1089/thy.2005.15.700
   Tikhonoff V, 2014, J HYPERTENS, V32, P1590, DOI 10.1097/HJH.0000000000000244
   Valkanova V, 2013, BIOL PSYCHIAT, V73, P406, DOI 10.1016/j.biopsych.2012.10.028
   Vogelzangs N, 2011, J CLIN PSYCHIAT, V72, P598, DOI 10.4088/JCP.10m06559
   Vos T, 2015, LANCET, V386, P743, DOI 10.1016/S0140-6736(15)60692-4
   Whooley MA, 2013, ANNU REV CLIN PSYCHO, V9, P327, DOI 10.1146/annurev-clinpsy-050212-185526
   Zhang MWB, 2011, GEN HOSP PSYCHIAT, V33, P217, DOI 10.1016/j.genhosppsych.2011.03.009
NR 81
TC 34
Z9 37
U1 1
U2 23
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD OCT 1
PY 2019
VL 257
BP 486
EP 494
DI 10.1016/j.jad.2019.07.003
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA IS8CQ
UT WOS:000482376300061
PM 31319340
DA 2025-06-11
ER

PT J
AU de Cavanagh, EMV
   Inserra, F
   Ferder, M
   Ferder, L
AF de Cavanagh, E. M. V.
   Inserra, F.
   Ferder, M.
   Ferder, L.
TI From mitochondria to disease: Role of the renin-angiotensin system
SO AMERICAN JOURNAL OF NEPHROLOGY
LA English
DT Review
DE aging; oxidative stress; angiotensin II; mitochondria; hypertension;
   renin-angiotensin system; cardiovascular disease; kidney; diabetes;
   reactive oxygen species
ID SPONTANEOUSLY HYPERTENSIVE-RATS; TUMOR-NECROSIS-FACTOR; NITRIC-OXIDE;
   ENDOTHELIAL-CELLS; OXIDATIVE STRESS; SUPEROXIDE-PRODUCTION;
   HYDROGEN-PEROXIDE; INDUCED APOPTOSIS; ACE-INHIBITORS;
   SUCCINATE-DEHYDROGENASE
AB Mitochondria are energy-producing organelles that conduct other key cellular tasks. Thus, mitochondrial damage may impair various aspects of tissue functioning. Mitochondria generate oxygen-and nitrogen-derived oxidants, being themselves major oxidation targets. Dysfunctional mitochondria seem to contribute to the pathophysiology of hypertension, cardiac failure, the metabolic syndrome, obesity, diabetes mellitus, renal disease, atherosclerosis, and aging. Mitochondrial proteins and metabolic intermediates participate in various cellular processes, apart from their well-known roles in energy metabolism. This emphasizes the participation of dysfunctional mitochondria in disease, notwithstanding that most evidences supporting this concept come from animal and cultured-cell studies. Mitochondrial oxidant production is altered by several factors related to vascular pathophysiology. Among these, angiotensin-II stimulates mitochondrial oxidant release leading to energy metabolism depression. By lowering mitochondrial oxidant production, angiotensin-II inhibition enhances energy production and protects mitochondrial structure. This seems to be one of the mechanisms underlying the benefits of angiotensinII inhibition in hypertension, diabetes, and aging rodent models. If some of these findings can be reproduced in humans, they would provide a new perspective on the implications that RAS-blockade can offer as a therapeutic strategy. This review intends to present available information pointing to mitochondria as targets for therapeutic Ang-II blockade in human renal and CV disease. Copyright (C) 2007 S. Karger AG, Basel.
C1 Ponce Sch Med, Dept Physiol & Pharmacol, Ponce, PR 00732 USA.
   Univ Buenos Aires, Sch Med, Cardiovasc Res Inst, Lab Expt Nephrol, Buenos Aires, DF, Argentina.
C3 University of Buenos Aires; Instituto Cardiovascular de Buenos Aires
   (ICBA)
RP de Cavanagh, EMV (corresponding author), Ponce Sch Med, Dept Physiol & Pharmacol, POB 7004, Ponce, PR 00732 USA.
EM leferder@psm.edu
CR Alvarez S, 2003, BIOCHEM BIOPH RES CO, V305, P771, DOI 10.1016/S0006-291X(03)00818-0
   Andreyev AI, 2005, BIOCHEMISTRY-MOSCOW+, V70, P200, DOI 10.1007/s10541-005-0102-7
   [Anonymous], 2004, DIABETES CARE, V27, pS79
   Ardehali H, 2004, P NATL ACAD SCI USA, V101, P11880, DOI 10.1073/pnas.0401703101
   Asmis R, 2003, CIRC RES, V92, pE20, DOI 10.1161/01.RES.0000051886.43510.90
   BASSO N, 2007, IN PRESS AM J PHYSL
   Baylis C, 1997, MECH AGEING DEV, V97, P163, DOI 10.1016/S0047-6374(97)00053-5
   Beckman KB, 1998, ANN NY ACAD SCI, V854, P118, DOI 10.1111/j.1749-6632.1998.tb09897.x
   Benderdour M, 2004, AM J PHYSIOL-HEART C, V287, pH2122, DOI 10.1152/ajpheart.00378.2004
   Bosch J, 2005, CIRCULATION, V112, P1339, DOI 10.1161/CIRCULATIONAHA.105.548461
   BOVERIS A, 1973, BIOCHEM J, V134, P707, DOI 10.1042/bj1340707
   Boveris A, 2000, ANN NY ACAD SCI, V899, P121
   Brand MD, 2004, FREE RADICAL BIO MED, V37, P755, DOI 10.1016/j.freeradbiomed.2004.05.034
   Brodsky SV, 2002, AM J PHYSIOL-HEART C, V283, pH2130, DOI 10.1152/ajpheart.00196.2002
   Brookes P, 2002, FREE RADICAL BIO MED, V32, P370, DOI 10.1016/S0891-5849(01)00805-X
   Brookes PS, 2000, J BIOL CHEM, V275, P20474, DOI 10.1074/jbc.M001077200
   Cadenas E, 2000, FREE RADICAL BIO MED, V29, P222, DOI 10.1016/S0891-5849(00)00317-8
   Casademont Jordi, 2002, Heart Fail Rev, V7, P131, DOI 10.1023/A:1015372407647
   Ceaser EK, 2003, AM J PHYSIOL-HEART C, V285, pH2298, DOI 10.1152/ajpheart.00508.2003
   CERUTTI PA, 1991, CANCER CELL-MON REV, V3, P1
   CHANCE B, 1979, PHYSIOL REV, V59, P527, DOI 10.1152/physrev.1979.59.3.527
   CHEN G, 2004, YI JUN YI XUE XUE BA, V24, P827
   Dahlöf B, 1998, HYPERTENSION, V32, P989, DOI 10.1161/01.HYP.32.6.989
   de Cavanagh EMV, 2006, AM J PHYSIOL-REG I, V290, pR1616, DOI 10.1152/ajpregu.00615.2005
   De Cavanagh EMV, 2005, CELL MOL BIOL, V51, P573, DOI 10.1170/T665
   de Cavanagh EMV, 2003, FASEB J, V17, P1096, DOI 10.1096/fj.02-0063fje
   DECAVANAGH E, 2004, 14 EUR M HYP PAR
   Doughan AK, 2005, FREE RADICAL BIO MED, V39, pS23
   Duszynski J, 2006, BBA-BIOENERGETICS, V1757, P380, DOI 10.1016/j.bbabio.2006.04.017
   Erdmann B, 1996, HYPERTENSION, V28, P818, DOI 10.1161/01.HYP.28.5.818
   FERDER L, 1993, AM J PHYSIOL, V265, pC15, DOI 10.1152/ajpcell.1993.265.1.C15
   Ferder L, 1998, AM J HYPERTENS, V11, P1297, DOI 10.1016/S0895-7061(98)00152-6
   Gogvadze V, 2006, BBA-BIOENERGETICS, V1757, P639, DOI 10.1016/j.bbabio.2006.03.016
   Goldenberg I, 2001, J HYPERTENS, V19, P1681, DOI 10.1097/00004872-200109000-00022
   Goldenthal MJ, 2004, MOL CELL BIOCHEM, V262, P1, DOI 10.1023/B:MCBI.0000038228.85494.3b
   Grivennikova VG, 2006, BBA-BIOENERGETICS, V1757, P553, DOI 10.1016/j.bbabio.2006.03.013
   Gutteridge JMC, 2000, ANN NY ACAD SCI, V899, P136, DOI 10.1111/j.1749-6632.2000.tb06182.x
   Gwinner W, 2000, NEPHROL DIAL TRANSPL, V15, P1127, DOI 10.1093/ndt/15.8.1127
   Hall AM, 2007, NEPHRON PHYSIOL, V105, P1, DOI 10.1159/000096860
   Halliwell B., 1999, Free Radicals in Biology and Medicine, V3 rd, P617
   Harada K, 2002, HYPERTENS RES, V25, P683
   Hastings Richard A., 2002, American Journal of Hypertension, V15, p13A, DOI 10.1016/S0895-7061(02)02307-5
   He WH, 2004, NATURE, V429, P188, DOI 10.1038/nature02488
   INSERRA F, 1995, HYPERTENSION, V25, P437, DOI 10.1161/01.HYP.25.3.437
   Irwin WA, 2003, NAT GENET, V35, P367, DOI 10.1038/ng1270
   Ishola DA, 2006, KIDNEY INT, V70, P724, DOI 10.1038/sj.ki.5001629
   Jones SP, 2003, CIRC RES, V93, P697, DOI 10.1161/01.RES.0000097262.21507.DF
   Katyare SS, 2005, DIABETES OBES METAB, V7, P555, DOI 10.1111/j.1463-1326.2004.00429.x
   Kimura S, 2005, HYPERTENSION, V45, P438, DOI 10.1161/01.HYP.0000157169.27818.ae
   Korge P, 2003, AM J PHYSIOL-HEART C, V285, pH259, DOI 10.1152/ajpheart.01028.2002
   Larkin JE, 2004, PHYSIOL GENOMICS, V18, P152, DOI 10.1152/physiolgenomics.00057.2004
   Leary SC, 2002, AM J PHYSIOL-HEART C, V283, pH540, DOI 10.1152/ajpheart.00032.2002
   Li DY, 1999, AM J PHYSIOL-HEART C, V276, pH786, DOI 10.1152/ajpheart.1999.276.3.H786
   LOSCHEN G, 1971, FEBS LETT, V18, P261, DOI 10.1016/0014-5793(71)80459-3
   Makino H, 2000, KIDNEY INT, V58, pS67, DOI 10.1046/j.1523-1755.2000.07711.x
   Manna SK, 1998, J BIOL CHEM, V273, P13245, DOI 10.1074/jbc.273.21.13245
   Marí M, 2006, CELL METAB, V4, P185, DOI 10.1016/j.cmet.2006.07.006
   Messner KR, 2002, J BIOL CHEM, V277, P42563, DOI 10.1074/jbc.M204958200
   Miquel J, 1998, EXP GERONTOL, V33, P113, DOI 10.1016/S0531-5565(97)00060-0
   Mollnau H, 2002, CIRC RES, V90, pE58, DOI 10.1161/01.RES.0000012569.55432.02
   Monteiro P, 2005, EUR J PHARMACOL, V518, P158, DOI 10.1016/j.ejphar.2005.06.013
   Monteiro Pedro, 2005, Rev Port Cardiol, V24, P53
   Moreira P I, 2006, Med Chem, V2, P299, DOI 10.2174/157340606776930754
   Muller FL, 2004, J BIOL CHEM, V279, P49064, DOI 10.1074/jbc.M407715200
   Münzel T, 2001, CIRCULATION, V104, P1571, DOI 10.1161/hc3801.095585
   Nishikawa T, 2000, NATURE, V404, P787, DOI 10.1038/35008121
   Okado-Matsumoto A, 2001, J BIOL CHEM, V276, P38388, DOI 10.1074/jbc.M105395200
   Opie LH, 2001, LANCET, V358, P1829, DOI 10.1016/S0140-6736(01)06879-9
   Park J B, 2000, J Renin Angiotensin Aldosterone Syst, V1, P40, DOI 10.3317/jraas.2000.009
   Peters J, 1996, AM J PHYSIOL-ENDOC M, V271, pE439, DOI 10.1152/ajpendo.1996.271.3.E439
   PFEFFER MA, 1992, NEW ENGL J MED, V327, P669, DOI 10.1056/NEJM199209033271001
   Piotrkowski B, 2007, AM J PHYSIOL-REG I, V292, pR1494, DOI 10.1152/ajpregu.00540.2006
   Poderoso JJ, 1996, ARCH BIOCHEM BIOPHYS, V328, P85, DOI 10.1006/abbi.1996.0146
   Pueyo ME, 1998, AM J PHYSIOL-CELL PH, V274, pC214, DOI 10.1152/ajpcell.1998.274.1.C214
   Pueyo ME, 2000, ARTERIOSCL THROM VAS, V20, P645, DOI 10.1161/01.ATV.20.3.645
   PURI PL, 1995, J BIOL CHEM, V270, P22129, DOI 10.1074/jbc.270.38.22129
   Rachek LI, 2006, DIABETES, V55, P1022, DOI 10.2337/diabetes.55.04.06.db05-0865
   Ramachandran A, 2004, P NATL ACAD SCI USA, V101, P384, DOI 10.1073/pnas.0304653101
   Ramachandran A, 2002, FREE RADICAL BIO MED, V33, P1465, DOI 10.1016/S0891-5849(02)01142-5
   Rincon-Choles H., 2002, KIDNEY INT, P8
   ROBERTSON AL, 1971, SCIENCE, V172, P1138, DOI 10.1126/science.172.3988.1138
   Rueckschloss U, 2002, ARTERIOSCL THROM VAS, V22, P1845, DOI 10.1161/01.ATV.0000035392.38687.65
   Rupprecht HD, 1996, KIDNEY INT, V49, P1575, DOI 10.1038/ki.1996.228
   SANBE A, 1995, J MOL CELL CARDIOL, V27, P2209, DOI 10.1016/S0022-2828(95)91551-6
   Sastre J, 1998, FREE RADICAL BIO MED, V24, P298, DOI 10.1016/S0891-5849(97)00228-1
   Schriner SE, 2005, SCIENCE, V308, P1909, DOI 10.1126/science.1106653
   SCHULZEOSTHOFF K, 1992, J BIOL CHEM, V267, P5317
   Semenkovich CF, 2006, J CLIN INVEST, V116, P1813, DOI 10.1172/JCI29024
   SHIGENAGA MK, 1994, P NATL ACAD SCI USA, V91, P10771, DOI 10.1073/pnas.91.23.10771
   Shishido S, 2003, HEPATOLOGY, V37, P136, DOI 10.1053/jhep.2003.50014
   SIRETT NE, 1977, BRAIN RES, V122, P299, DOI 10.1016/0006-8993(77)90296-7
   Skulachev VP, 2006, APOPTOSIS, V11, P473, DOI 10.1007/s10495-006-5881-9
   SOHAL RS, 1994, MECH AGEING DEV, V74, P121, DOI 10.1016/0047-6374(94)90104-X
   Sorescu Dan, 2002, Congest Heart Fail, V8, P132, DOI 10.1111/j.1527-5299.2002.00717.x
   Starkov AA, 2004, J NEUROSCI, V24, P7779, DOI 10.1523/JNEUROSCI.1899-04.2004
   STERZEL RB, 1993, KIDNEY INT, V43, pS26
   Sugiyama H, 1998, KIDNEY INT, V54, P1188, DOI 10.1046/j.1523-1755.1998.00116.x
   Suzuki YJ, 1997, FREE RADICAL BIO MED, V22, P269, DOI 10.1016/S0891-5849(96)00275-4
   Thomas DD, 2001, P NATL ACAD SCI USA, V98, P355, DOI 10.1073/pnas.98.1.355
   Thompson MM, 2000, AM J PHYSIOL-REG I, V279, pR1787, DOI 10.1152/ajpregu.2000.279.5.R1787
   Touyz RM, 2004, HYPERTENSION, V44, P248, DOI 10.1161/01.HYP.0000138070.47616.9d
   Touyz RM, 2003, J HYPERTENS, V21, P2235, DOI 10.1097/00004872-200312000-00007
   Touyz RM, 2000, PHARMACOL REV, V52, P639
   Turrens JF, 2003, J PHYSIOL-LONDON, V552, P335, DOI 10.1113/jphysiol.2003.049478
   Wallace DC, 1999, SCIENCE, V283, P1482, DOI 10.1126/science.283.5407.1482
   Wang MY, 2003, HYPERTENSION, V41, P1308, DOI 10.1161/01.HYP.0000073843.56046.45
   Wisloff U, 2005, SCIENCE, V307, P418, DOI 10.1126/science.1108177
   Wolf G, 2004, HYPERTENSION, V43, P693, DOI 10.1161/01.HYP.0000120963.09029.ca
   Wu D, 2005, J AM SOC NEPHROL, V16, P646, DOI 10.1681/ASN.2004060445
   Xia Y, 1998, J BIOL CHEM, V273, P12593, DOI 10.1074/jbc.273.20.12593
NR 110
TC 108
Z9 121
U1 0
U2 13
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-8095
EI 1421-9670
J9 AM J NEPHROL
JI Am. J. Nephrol.
PY 2007
VL 27
IS 6
BP 545
EP 553
DI 10.1159/000107757
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 219OK
UT WOS:000250094300001
PM 17785964
OA Bronze
DA 2025-06-11
ER

PT J
AU Wang, S
   Zhang, L
   Wu, YG
   Ma, J
AF Wang, Si
   Zhang, Lin
   Wu, Yigao
   Ma, Jun
TI Clinical Patterns of Metabolic Syndrome in First-Hospitalized Major
   Depressive Disorder Patients: Comparison of Antidepressant-Exposed and
   Drug-Naïve Groups
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Article
DE major depressive disorder; metabolic syndrome; antidepressant-exposed;
   drug-na & iuml;ve; risk factor
ID PROSPECTIVE ASSOCIATIONS; LIFE-STYLE; PREVALENCE; ANXIETY; HEALTH;
   ABNORMALITIES; OVERWEIGHT; SEVERITY; SYMPTOMS; OBESITY
AB Background: Major depressive disorder (MDD) and metabolic syndrome (MetS) are both major health threats nowadays, and the relationship between them is complex and close. The purpose of this paper is to compare differences in the prevalence and risk factors of MetS in first hospitalized patients with MDD with and without antidepressant exposure. Methods: A total of 636 first hospitalized MDD patients (study group) with antidepressant exposure and 345 drug-na & iuml;ve patients (control group) were included in this study. Their socio-demographic data, routine biochemical indices, and psychological symptom assessment were collected. Results: There was no difference in the prevalence of MetS between the study group and the control group (F = 2.49, p = 0.115). Factors affecting MetS and its severity differed between the two groups, in the study group, the identified risk factors for MetS were onset age (B = 0.05, p <0.001, OR = 1.05, 95% CI = 1.02-1.08), TSH level (B = 0.42, p <0.001, OR = 1.53, 95% CI = 1.39-1.68). Meanwhile, in the control group, the identified risk factors for MetS were more extensive and they were, onset age (B = 0.11, p <0.001, OR = 1.12, 95% CI = 1.07-1.16), suicidal behavior (B = 1.54, p = 0.007, OR = 4.65, 95% CI = 1.51-14.33), HAMD scores (B = 0.23, p = 0.008, OR = 1.26, 95% CI = 1.06-1.49) and TSH levels (B = 0.33, p <0.001, OR = 1.39, 95% CI = 1.17-1.65). The number of risk factors identified was lower in the study group. Conclusion: Antidepressant use was associated with greater MetS severity but did not affect overall prevalence. Antidepressants appear to modify MetS risk factors, highlighting the need to differentiate these effects from those in drug-na & iuml;ve patients when developing MetS interventions for the MDD population.
C1 [Wang, Si; Zhang, Lin; Ma, Jun] Wuhan Mental Hlth Ctr, Dept Psychiat, 89 Gongnongbing Rd, Wuhan, Hubei, Peoples R China.
   [Wang, Si; Zhang, Lin; Ma, Jun] Wuhan Hosp Psychotherapy, Dept Psychiat, Wuhan, Peoples R China.
   [Wu, Yigao] First Affiliated Hosp, Wannan Med Coll, Dept Med Psychol, 2 Zheshan West Rd, Wuhu, Peoples R China.
C3 Wannan Medical College
RP Ma, J (corresponding author), Wuhan Mental Hlth Ctr, Dept Psychiat, 89 Gongnongbing Rd, Wuhan, Hubei, Peoples R China.; Wu, YG (corresponding author), First Affiliated Hosp, Wannan Med Coll, Dept Med Psychol, 2 Zheshan West Rd, Wuhu, Peoples R China.
EM wuyigao2000@126.com; majun0313@wo.cn
RI Ma, Jun/HLV-7600-2023
OI Ma, Jun/0000-0001-5633-6839; Wu, Yigao/0000-0001-6706-0436
FU Key projects of Anhui Humanities and Social Sciences Research Base
   [SK2019A0226]; Japanese Mental Health Okamoto Memorial Foundation
   Research Assistance Project
FX This work was supported by Key projects of Anhui Humanities and Social
   Sciences Research Base (SK2019A0226 to YW: PI) and Japanese Mental
   Health Okamoto Memorial Foundation Research Assistance Project (Heisei
   31 Research 3 to YW: PI) .
CR Afshin A, 2017, NEW ENGL J MED, V377, P13, DOI 10.1056/NEJMoa1614362
   Association AP, 2013, Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
   Çakici N, 2020, BRAIN BEHAV IMMUN, V88, P547, DOI 10.1016/j.bbi.2020.04.039
   Carvalho AF, 2016, PSYCHOTHER PSYCHOSOM, V85, P270, DOI 10.1159/000447034
   Crichton GE, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-3170-2
   Dortland AKBV, 2010, ACTA PSYCHIAT SCAND, V122, P30, DOI 10.1111/j.1600-0447.2010.01565.x
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Fernandes BS, 2022, NEUROSCI BIOBEHAV R, V139, DOI 10.1016/j.neubiorev.2022.104758
   Group C. E. C. o. S. D. a. T. o. T. H. C.-m. V. E., 2023, Chin Med J Cardiolo, V06, P1, DOI [10.3760/cma.j.cn116031.2023.1000144, DOI 10.3760/CMA.J.CN116031.2023.1000144]
   Grover Sandeep, 2013, Indian J Psychol Med, V35, P167, DOI 10.4103/0253-7176.116247
   Gurka MJ, 2016, PSYCHONEUROENDOCRINO, V68, P82, DOI 10.1016/j.psyneuen.2016.02.030
   Hidese S, 2018, J PSYCHIATR RES, V102, P23, DOI 10.1016/j.jpsychires.2018.02.009
   Hiles SA, 2016, DEPRESS ANXIETY, V33, P754, DOI 10.1002/da.22512
   Himmerich H, 2015, ENDOCR METAB IMMUNE, V15, P252, DOI 10.2174/1871530315666150623092031
   Hu JQ, 2023, J PSYCHIATR RES, V163, P55, DOI 10.1016/j.jpsychires.2023.05.016
   Huang YQ, 2019, LANCET PSYCHIAT, V6, P211, DOI 10.1016/S2215-0366(18)30511-X
   Joint committee issued Chinese guideline for the management of dyslipidemia in adults, 2016, Zhonghua Xin Xue Guan Bing Za Zhi, V44, P833, DOI 10.3760/cma.j.issn.0253-3758.2016.10.005
   Lee SH, 2016, TRANSL PSYCHIAT, V6, DOI 10.1038/tp.2016.25
   Liu D, 2021, PROG NEURO-PSYCHOPH, V111, DOI 10.1016/j.pnpbp.2021.110339
   Luppino FS, 2011, PSYCHOSOM MED, V73, P257, DOI 10.1097/PSY.0b013e31820a59c0
   McIntyre RS, 2010, CNS DRUGS, V24, P741, DOI 10.2165/11533280-000000000-00000
   Moreira FP, 2017, J PSYCHIATR RES, V92, P119, DOI 10.1016/j.jpsychires.2017.03.025
   Otte C, 2016, NAT REV DIS PRIMERS, V2, DOI 10.1038/nrdp.2016.65
   Peng P, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1138233
   de Melo LGP, 2017, PROG NEURO-PSYCHOPH, V78, P34, DOI 10.1016/j.pnpbp.2017.04.027
   Postolache TT, 2019, AM J MED GENET B, V180, P186, DOI 10.1002/ajmg.b.32712
   Ranasinghe P, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4041-1
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Scheen AJ, 2023, ANN ENDOCRINOL-PARIS, V84, P357, DOI 10.1016/j.ando.2023.03.006
   Schneider J Gabriel, 2006, Cardiol Rev, V14, P286, DOI 10.1097/01.crd.0000233757.15181.67
   Si T, 2021, J AFFECT DISORDERS, V286, P351, DOI 10.1016/j.jad.2021.01.037
   Smith TW, 2017, ANN BEHAV MED, V51, P610, DOI 10.1007/s12160-017-9883-3
   [中国心血管健康与疾病报告编写组 The Writing Committee of The Report on Cardiovascular Health And Diseases in China], 2022, [中国循环杂志, Chinese Circulation Journal], V37, P553
   Uher R, 2014, DEPRESS ANXIETY, V31, P459, DOI 10.1002/da.22217
   Vancampfort D, 2014, PSYCHOL MED, V44, P2017, DOI 10.1017/S0033291713002778
   Verhoeven JE, 2023, J AFFECT DISORDERS, V329, P19, DOI 10.1016/j.jad.2023.02.064
   Vos T, 2020, LANCET, V396, P1562
   Wang YQ, 2021, J AFFECT DISORDERS, V287, P41, DOI 10.1016/j.jad.2021.03.023
   Wen FK, 2020, CAN FAM PHYSICIAN, V66, P898, DOI 10.46747/cfp.6612898
   Wu MY, 2022, EUR J CLIN INVEST, V52, DOI 10.1111/eci.13646
   Xi B, 2013, PREV MED, V57, P867, DOI 10.1016/j.ypmed.2013.09.023
   Yao F, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124475
   Zeng K, 2023, ANN GEN PSYCHIATR, V22, DOI 10.1186/s12991-023-00455-0
   Zhao K, 2020, BMC PSYCHIATRY, V20, DOI 10.1186/s12888-020-02791-x
NR 44
TC 0
Z9 0
U1 0
U2 1
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2024
VL 20
BP 2159
EP 2168
DI 10.2147/NDT.S494619
PG 10
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA M4G4W
UT WOS:001357142800001
PM 39564596
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Corona, G
   Mannucci, E
   Schulman, C
   Petrone, L
   Mansani, R
   Cilotti, A
   Balercia, G
   Chiarini, V
   Forti, G
   Maggi, M
AF Corona, Giovanni
   Mannucci, Edoardo
   Schulman, Claude
   Petrone, Luisa
   Mansani, Riccardo
   Cilotti, Antonio
   Balercia, Giancarlo
   Chiarini, Valerio
   Forti, Gianni
   Maggi, Mario
TI Psychobiologic correlates of the metabolic syndrome and associated
   sexual dysfunction
SO EUROPEAN UROLOGY
LA English
DT Article
DE erectile dysfunction; hypogonadism; metabolic syndrome; SIEDY;
   testosterone
ID ERECTILE DYSFUNCTION; INSULIN-RESISTANCE; RISK-FACTORS; TESTOSTERONE;
   MEN; PREVALENCE; ANDROGENS; HYPOGONADISM; OBESITY; ONSET
AB Objectives: The association of low testosterone level and erectile dysfunction (ED) with metabolic syndrome (MS) is receiving increasing attention. The present study determined the psychobiologic characteristics of sexual dysfunction (SD) associated with MS (as defined by the National Cholesterol Education Program's Adult Treatment Panel III criteria) in a series of 803 consecutive male outpatients.
   Methods: Several hormonal, biochemical, and instrumental (penile Doppler ultrasound [PDU]) parameters were studied, along with general psychopathology scores (Middlesex Hospital Questionnaire modified [MHQ]). The Structured Interview on Erectile Dysfunction (SIEDY) was also applied.
   Results: Among the 236 patients (29.4%) diagnosed as having a MS, 96.5% reported ED, 39.6% hypoactive sexual desire (HSD), 22.7% premature ejaculation, and 4.8% delayed ejaculation. Patients with MS were characterised by greater subjective (as assessed by SIEDY) and objective (as assessed by PDU) ED and by greater somatised anxiety than the rest of the sample. The prevalence of overt hypogonadism (total testosterone < 8 nM) was significantly higher in patients with MS. Among MS components, waist circumference and hyperglycaemia were the best predictors of hypogonadism. Hypogonadal patients with MS showed higher gonadotropin and lower free testosterone levels, suggesting a primary hypogonadism. Among patients with MS, hypogonadism was present in 11.9% and 3.8% in the rest of the sample (p < 0.0001) and was associated with typical hypogonadism-related symptoms, such as hypoactive sexual desire, low frequency of sexual intercourse, and depressive symptoms.
   Conclusions: Our data suggest that MS is associated with a more severe ED and induces somatisation. Furthermore, MS is associated with a higher prevalence of hypogonadism in patients with SD. The presence of hypogonadism can further exacerbate the MS-associated sexual dysfunction, adding the typical hypogonadisin-related symptoms (including HSD, 66.7%). Recognising MS associated with hypogonadism is important for both sexual and general health and its serious potential associated risks. (c) 2006 European Association of Urology. Published by Elsevier B.V. All rights reserved.
C1 Univ Florence, Androl Unit, Dept Clin Physiopathol, I-50139 Florence, Italy.
   Univ Florence, Diabet Sect, Geriat Unit, Dept Crit Care, I-50139 Florence, Italy.
   Univ Clin Brussels, Erasme Hosp, Dept Urol, Brussels, Belgium.
   Polytech Univ Marche, Endocrinol Unit, Ancona, Italy.
   Maggiore Bellaria Hosp, Endocrinol Unit, Bologna, Italy.
C3 University of Florence; University of Florence; Universite Libre de
   Bruxelles; Marche Polytechnic University; AUSL di Bologna
RP Maggi, M (corresponding author), Univ Florence, Androl Unit, Dept Clin Physiopathol, Viale Pieraccini 6, I-50139 Florence, Italy.
EM m.maggi@dfc.unifi.it
RI Petrone, Luisa/L-1805-2018; Maggi, Mario/AAB-8284-2019; Mannucci,
   Edoardo/K-6749-2016
OI Mannucci, Edoardo/0000-0001-9759-9408; MAGGI, Mario/0000-0003-3267-4221
CR Apfelbaum B, 2000, PRINCIPLES AND PRACTICE OF SEX THERAPY, THIRD EDITION, P205
   Aversa A, 2005, EUR UROL, V47, P564, DOI 10.1016/j.eururo.2004.12.004
   Cameron AJ, 2004, ENDOCRIN METAB CLIN, V33, P351, DOI 10.1016/j.ecl.2004.03.005
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Corona G, 2005, INT J IMPOT RES, V17, P252, DOI 10.1038/sj.ijir.3901298
   Corona G, 2004, EUR UROL, V46, P615, DOI 10.1016/j.eururo.2004.07.001
   Corona G, 2004, EUR UROL, V46, P222, DOI 10.1016/j.eururo.2004.03.010
   CORONA G, 2005, IN PRESS INT J  1103
   CROWN S, 1966, BRIT J PSYCHIAT, V112, P917, DOI 10.1192/bjp.112.490.917
   Dioguardi N, 1984, Minerva Med, V75, P2793
   Ebert T, 2005, EUR UROL, V47, P137, DOI 10.1016/j.eururo.2004.09.015
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Esposito K, 2005, INT J IMPOT RES, V17, P391, DOI 10.1038/sj.ijir.3901333
   Esposito K, 2005, DIABETES CARE, V28, P1201, DOI 10.2337/diacare.28.5.1201
   ESPOSITO K, 2006, INT J IMPOT RES, V5, P1
   Gazzaruso C, 2004, CIRCULATION, V110, P22, DOI 10.1161/01.CIR.0000133278.81226.C9
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Isidori AM, 2005, CLIN ENDOCRINOL, V63, P381, DOI 10.1111/j.1365-2265.2005.02350.x
   Jones RD, 2004, EUR J ENDOCRINOL, V151, P29, DOI 10.1530/eje.0.1510029
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   Kapoor D, 2005, CLIN ENDOCRINOL, V63, P239, DOI 10.1111/j.1365-2265.2005.02299.x
   Kaufman JM, 2005, ENDOCR REV, V26, P833, DOI 10.1210/er.2004-0013
   Kragelund C, 2005, LANCET, V366, P1589, DOI 10.1016/S0140-6736(05)67642-8
   Lemieux I, 2000, CIRCULATION, V102, P179, DOI 10.1161/01.CIR.102.2.179
   Makhsida N, 2005, J UROLOGY, V174, P827, DOI 10.1097/01.ju.0000169490.78443.59
   Mancini M, 2000, INT J ANDROL, V23, P199
   Mårin P, 1998, BAILLIERE CLIN ENDOC, V12, P441, DOI 10.1016/S0950-351X(98)80191-2
   Mokdad AH, 2005, JAMA-J AM MED ASSOC, V293, P293, DOI 10.1001/jama.293.3.293
   Montorsi F, 2003, EUR UROL, V44, P360, DOI 10.1016/S0302-2838(03)00305-1
   Montorsi P, 2003, EUR UROL, V44, P352, DOI 10.1016/S0302-2838(03)00307-5
   Morelli A, 2005, INT J ANDROL, V28, P23, DOI 10.1111/j.1365-2605.2005.00550.x
   Nieschlag E, 2005, EUR UROL, V48, P1, DOI 10.1016/j.eururo.2005.04.027
   *NIH CONS DEV PAN, 1999, JAMA-J AM MED ASSOC, V279, P83
   Petrone L, 2003, INT J IMPOT RES, V15, P210, DOI 10.1038/sj.ijir.3901006
   Pitteloud N, 2005, J CLIN ENDOCR METAB, V90, P2636, DOI 10.1210/jc.2004-2190
   Ponholzer A, 2005, EUR UROL, V47, P80, DOI 10.1016/j.eururo.2004.08.017
   Smith GD, 1997, BMJ-BRIT MED J, V315, P1641, DOI 10.1136/bmj.315.7123.1641
   Stumvoll M, 2005, LANCET, V365, P1333, DOI 10.1016/S0140-6736(05)61032-X
   Vignozzi L, 2005, J Endocrinol Invest, V28, P39
   Wang C, 2005, J CLIN ENDOCR METAB, V90, P3550, DOI 10.1210/jc.2004-1530
   Wegner D.M., 1996, SOC PSYCHOL-GERMANY, P466
   Yusuf S, 2005, LANCET, V366, P1640, DOI 10.1016/S0140-6736(05)67663-5
NR 42
TC 150
Z9 160
U1 0
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0302-2838
EI 1873-7560
J9 EUR UROL
JI Eur. Urol.
PD SEP
PY 2006
VL 50
IS 3
BP 595
EP 604
DI 10.1016/j.eururo.2006.02.053
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 079YU
UT WOS:000240214600034
PM 16564129
DA 2025-06-11
ER

PT J
AU Rolla, AR
AF Rolla, Arturo R.
TI Addressing the Need to Tailor Treatment to the Spectrum of Type 2
   Diabetes: New Perspectives
SO DIABETES TECHNOLOGY & THERAPEUTICS
LA English
DT Review
ID METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; MORTALITY; INSULIN;
   MELLITUS; RISK; COMPLICATIONS; EPIDEMIOLOGY; HYPOGLYCEMIA; DEPRESSION
AB Type 2 diabetes mellitus is characterized by the progressive loss of beta cell function, which occurs after many years of insulin resistance. Within this definition, clinicians may see a diverse array of presentations, suggesting different proportions of these two pathogenic factors and a complex etiology. There are also differences in the rate of type 2 diabetes progression in each patient, so treatments must be reviewed frequently to respond to changing severity of pathophysiologies. This article first considers some of the heritable factors and the pathogenic heterogeneity of type 2 diabetes. Relevant socioeconomic and demographic factors influencing disease development are reviewed after that, while emphasizing how a patient's treatment requires changes over time.
C1 Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA.
C3 Harvard University; Harvard University Medical Affiliates; Beth Israel
   Deaconess Medical Center; Harvard Medical School
RP Rolla, AR (corresponding author), Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, 110 Francis St,Suite 2F, Boston, MA 02215 USA.
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   American Association of Clinical Endocrinologist (AACE), 2007, Endocr. Pr., V13, P1
   Balkau B, 1999, DIABETIC MED, V16, P442
   Barr DA, 2005, ANN INTERN MED, V143, P809, DOI 10.7326/0003-4819-143-11-200512060-00009
   Betteridge DJ, 2000, DIABETES OBES METAB, V2, pS31, DOI 10.1046/j.1463-1326.2000.00021.x
   Brown AF, 2004, EPIDEMIOL REV, V26, P63, DOI 10.1093/epirev/mxh002
   Buchanan Thomas A., 2003, Clinical Therapeutics, V25, pB32, DOI 10.1016/S0149-2918(03)80241-2
   CADDICK SL, 1994, DIABETIC MED, V11, P981, DOI 10.1111/j.1464-5491.1994.tb00257.x
   Chaturvedi N, 2007, DIABETES RES CLIN PR, V76, pS3, DOI 10.1016/j.diabres.2007.01.019
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cubbon R, 2008, INT J CLIN PRACT, V62, P287, DOI 10.1111/j.1742-1241.2007.01646.x
   Deedwania PC, 2005, CARDIOL CLIN, V23, P139, DOI 10.1016/j.ccl.2004.06.006
   Egede LE, 2005, MED CLIN N AM, V89, P949, DOI 10.1016/j.mcna.2005.03.004
   Freeman H, 2006, HUM MOL GENET, V15, pR202, DOI 10.1093/hmg/ddl191
   Garber AJ, 2007, J AM GERIATR SOC, V55, P1735, DOI 10.1111/j.1532-5415.2007.01414.x
   Gerstein HC, 2008, NEW ENGL J MED, V358, P2545, DOI 10.1056/NEJMoa0802743
   Haller H, 1977, Z Gesamte Inn Med, V32, P124
   Imazu M, 2002, DIABETES RES CLIN PR, V57, P61, DOI 10.1016/S0168-8227(02)00016-5
   Kozek Elzbieta, 2004, Rev Diabet Stud, V1, P122, DOI 10.1900/RDS.2004.1.122
   Kronmal RA, 2006, PLOS MED, V3, P1883, DOI 10.1371/journal.pmed.0030400
   Lanting LC, 2005, DIABETES CARE, V28, P2280, DOI 10.2337/diacare.28.9.2280
   Legato Marianne J, 2006, Gend Med, V3, P131, DOI 10.1016/S1550-8579(06)80202-0
   Luna MTT, 2005, ARCH MED RES, V36, P210, DOI 10.1016/j.arcmed.2005.03.004
   Lustman PJ, 2000, DIABETES CARE, V23, P934, DOI 10.2337/diacare.23.7.934
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Matyka K, 1997, DIABETES CARE, V20, P135, DOI 10.2337/diacare.20.2.135
   Mollema ED, 2001, J PSYCHOSOM RES, V51, P665, DOI 10.1016/S0022-3999(01)00229-X
   Murphy MJ, 2004, PEDIATRICS, V113, P82, DOI 10.1542/peds.113.1.82
   Musselman DL, 2003, BIOL PSYCHIAT, V54, P317, DOI 10.1016/S0006-3223(03)00569-9
   Nakagami T, 2003, DIABETOLOGIA, V46, P1063, DOI 10.1007/s00125-003-1158-9
   Nathan DM, 2006, DIABETES CARE, V29, P1963, DOI 10.2337/dc06-9912
   Prentki M, 2006, J CLIN INVEST, V116, P1802, DOI 10.1172/JCI29103
   Ryan MC, 2008, AM J CARDIOL, V102, P40, DOI 10.1016/j.amjcard.2008.02.096
   Smellie WSA, 2006, BMJ-BRIT MED J, V333, P1257, DOI 10.1136/bmj.39043.398738.DE
   Smith NL, 2002, J AM GERIATR SOC, V50, P416, DOI 10.1046/j.1532-5415.2002.50103.x
   Stratton IM, 2001, DIABETOLOGIA, V44, P156, DOI 10.1007/s001250051594
   TJOKROPRAWIRO A, 2005, FOL MED INDONES, V41, P159
   Wang JJ, 2007, EUR HEART J, V28, P857, DOI 10.1093/eurheartj/ehl524
   Wilkin TJ, 2006, INT J OBESITY, V30, P1056, DOI 10.1038/sj.ijo.0803317
   World Health Organization, 1999, WHONCDNCS992
   Zimmet P, 1999, ANN NY ACAD SCI, V892, P25, DOI 10.1111/j.1749-6632.1999.tb07783.x
NR 41
TC 1
Z9 2
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1520-9156
EI 1557-8593
J9 DIABETES TECHNOL THE
JI Diabetes Technol. Ther.
PD MAY
PY 2009
VL 11
IS 5
BP 267
EP 274
DI 10.1089/dia.2008.0075
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 444DD
UT WOS:000265959700001
PM 19425874
DA 2025-06-11
ER

PT J
AU Stanhope, KK
   Kramer, MR
AF Stanhope, Kaitlyn K.
   Kramer, Michael R.
TI Association Between Recommended Preconception Health Behaviors and
   Screenings and Improvements in Cardiometabolic Outcomes of Pregnancy
SO PREVENTING CHRONIC DISEASE
LA English
DT Article
ID ASSESSMENT MONITORING-SYSTEM; FACTOR SURVEILLANCE SYSTEM; INDICATORS;
   DISPARITIES; VALIDATION; MORTALITY
AB Introduction
   Gestational diabetes (GDM) and hypertensive disorders of pregnancy (HDP) are associated with increased risk of maternal and infant illness and long-term elevated cardiometabolic risk. Little information exists on the prevention of either disorder before pregnancy. Our goal was to describe the association between preconception indicators and risk of gestational diabetes and hypertensive disorders of pregnancy.
   Methods
   We used logistic regression to analyze cross-sectional data from the 2016-2017 Pregnancy Risk Assessment Monitoring System (N = 68,493) to quantify the association between 14 preconception health indicators (across domains of health care, nutrition and physical activity, tobacco and alcohol, chronic conditions, mental health, and emotional and social support) and, separately, GDM and HDP. We accounted for sampling weights and controlled for maternal age, race/ethnicity, prepregnancy insurance, prepregnancy body mass index, and report of a check-up in the year before pregnancy.
   Results
   Prepregnancy obesity was the strongest predictor of both HDP (adjusted odds ratio [aOR], 3.1; 95% CI, 2.8-3.5) and GDM (aOR, 3.1; 95% CI, 2.7-3.5). Individual behaviors (eg, exercise, attending a check-up) were not associated with either HDP or GDM. A diagnosis of diabetes before pregnancy predicted HDP (aOR, 2.3; 95% CI, 1.7-3.0).
   Conclusion
   Prepregnancy chronic disease and obesity predicted pregnancy complications (ie, GDM and HDP). Given the challenges in reversing these conditions in the year before pregnancy, efforts to improve preconception health may be best directed broadly to expand access to primary care for all women.
C1 [Stanhope, Kaitlyn K.] Emory Univ, Sch Med, Dept Gynecol & Obstet, Atlanta, GA USA.
   [Kramer, Michael R.] Emory Univ, Dept Epidemiol, Atlanta, GA USA.
C3 Emory University; Emory University
RP Stanhope, KK (corresponding author), Dept Gynecol & Obstet, Div Res, Atlanta, GA 30303 USA.
EM Kaitlyn.keirsey.stanhope@emory.edu
RI Kerisey, Kaitlyn/ABE-5436-2021
OI Stanhope, Kaitlyn/0000-0003-1540-3059
FU Health Resources and Services Administration Maternal and Child Health
   Bureau [T03MC07651]
FX Thank you to the CDC PRAMS Working Group and PRAMS participating states
   and respondents. This work was supported in part by Health Resources and
   Services Administration Maternal and Child Health Bureau, award no.
   T03MC07651. No copyrighted materials or tools were used in this
   research.
CR Alexopoulos AS, 2019, JAMA-J AM MED ASSOC, V321, P1811, DOI 10.1001/jama.2019.4981
   [Anonymous], 2019, Obstet Gynecol, V133, pe78, DOI 10.1097/AOG.0000000000003013
   Bain E, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010443.pub2
   Bardenheier BH, 2015, AM J PREV MED, V49, P12, DOI 10.1016/j.amepre.2015.01.026
   Battarbee AN, 2020, AM J OBSTET GYNECOL, V222, P532, DOI 10.1016/j.ajog.2019.11.1243
   Benschop L, 2019, HEART, V105, P1273, DOI 10.1136/heartjnl-2018-313453
   Bhatt CB, 2018, AM J PUBLIC HEALTH, V108, P565, DOI 10.2105/AJPH.2017.304218
   Chatzakis C, 2019, DIABETES RES CLIN PR, V158, DOI 10.1016/j.diabres.2019.107924
   Coroyannakis C, 2019, CURR HYPERTENS REP, V21, DOI 10.1007/s11906-019-0927-x
   DeSisto CL, 2014, PREV CHRONIC DIS, V11, DOI 10.5888/pcd11.130415
   Dietz P, 2015, PUBLIC HEALTH REP, V130, P60, DOI 10.1177/003335491513000108
   Dietz P, 2014, MATERN CHILD HLTH J, V18, P2489, DOI 10.1007/s10995-014-1487-y
   Dunlop AL, 2012, J WOMENS HEALTH, V21, P717, DOI 10.1089/jwh.2012.3763
   Eliason EL, 2020, WOMEN HEALTH ISS, V30, P147, DOI 10.1016/j.whi.2020.01.005
   Giannakou K, 2019, PLOS ONE, V14, DOI [10.1371/journal.pone.0215372, 10.1371]
   Hawkins SS, 2020, AM J PREV MED, V58, P165, DOI 10.1016/j.amepre.2019.09.012
   Hemsing N, 2017, SEX REPROD HEALTHC, V14, P24, DOI 10.1016/j.srhc.2017.08.004
   Hirshberg A, 2017, SEMIN PERINATOL, V41, P332, DOI 10.1053/j.semperi.2017.07.007
   Hitti J, 2018, AM J OBSTET GYNECOL, V219, DOI 10.1016/j.ajog.2018.07.002
   Fiore Anthony E., 2009, Morbidity and Mortality Weekly Report, V58, P1, DOI 10.1542/peds.2018-0939
   Martin J A., 2002, Births: Final data for 2000
   Nasiri-Amiri F, 2019, DIABETOL METAB SYNDR, V11, DOI 10.1186/s13098-019-0470-6
   Robbins C, 2018, MMWR SURVEILL SUMM, V67, P1, DOI 10.15585/mmwr.ss6701a1
   Robbins CL, 2014, MMWR SURVEILL SUMM, V63, P1
   Shawe J, 2019, OBES REV, V20, P1507, DOI 10.1111/obr.12927
   Shulman HB, 2018, AM J PUBLIC HEALTH, V108, P1305, DOI 10.2105/AJPH.2018.304563
   Smith GN, 2019, OBSTET GYNECOL, V134, P851, DOI 10.1097/AOG.0000000000003363
   Stuart JJ, 2018, ANN INTERN MED, V169, P224, DOI 10.7326/M17-2740
   Thompson EL, 2017, MATERN CHILD HLTH J, V21, P1147, DOI 10.1007/s10995-016-2213-8
   United States Department of Health and Human Services Centers for Disease Control and Prevention National Center for Health Statistics Division of Vital Statistics, 2020, NATALITY PUBLIC USE
NR 30
TC 5
Z9 7
U1 0
U2 2
PU CENTERS  DISEASE CONTROL & PREVENTION
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1545-1151
J9 PREV CHRONIC DIS
JI Prev. Chronic Dis.
PD JAN
PY 2021
VL 18
AR E06
DI 10.5888/pcd18.200481
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA QH4LV
UT WOS:000618248600006
PM 33476258
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bammann, K
   Gwozdz, W
   Pischke, C
   Eiben, G
   Fernandez-Alvira, JM
   De Henauw, S
   Lissner, L
   Moreno, LA
   Pitsiladis, Y
   Reisch, L
   Veidebaum, T
   Pigeot, I
AF Bammann, K.
   Gwozdz, W.
   Pischke, C.
   Eiben, G.
   Fernandez-Alvira, J. M.
   De Henauw, S.
   Lissner, L.
   Moreno, L. A.
   Pitsiladis, Y.
   Reisch, L.
   Veidebaum, T.
   Pigeot, I.
CA IDEFICS Consortium
TI The impact of familial, behavioural and psychosocial factors on the SES
   gradient for childhood overweight in Europe. A longitudinal study
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID CARDIOMETABOLIC RISK-FACTORS; VIGOROUS PHYSICAL-ACTIVITY; MENTAL-HEALTH
   PROBLEMS; SEDENTARY BEHAVIOR; ENVIRONMENTAL-FACTORS; OBESITY PREVENTION;
   OBJECTIVE MEASURES; CHILDREN; COHORT; MASS
AB BACKGROUND: In highly developed countries, childhood overweight and many overweight-related risk factors are negatively associated with socioeconomic status (SES).
   OBJECTIVE: The objective of this study is to investigate the longitudinal association between parental SES and childhood overweight, and to clarify whether familial, psychosocial or behavioural factors can explain any SES gradient.
   METHODS: The baseline and follow-up surveys of the identification and prevention of dietary and lifestyle induced health effects in children and infants (IDEFICS) study are used to investigate the longitudinal association between SES, familial, psychosocial and behavioural factors, and the prevalence of childhood overweight. A total of 5819 children (50.5% boys and 49.5% girls) were included.
   RESULTS: The risk for being overweight after 2 years at follow-up in children who were non-overweight at baseline increases with a lower SES. For children who were initially overweight, a lower parental SES carries a lower probability for a non-overweight weight status at follow-up. The effect of parental SES is only moderately attenuated by single familial, psychosocial or behavioural factors; however, it can be fully explained by their combined effect. Most influential of the investigated risk factors were feeding/eating practices, parental body mass index, physical activity behaviour and proportion of sedentary activity.
   CONCLUSION: Prevention strategies for childhood overweight should focus on actual behaviours, whereas acknowledging that these behaviours are more prevalent in lower SES families.
C1 [Bammann, K.] Univ Bremen, Inst Publ Hlth & Nursing Res ipp, Fac Human & Hlth Sci, FB 11,Grazer Str 2a, D-28359 Bremen, Germany.
   [Bammann, K.; Pischke, C.; Pigeot, I.] Leibniz Inst Prevent Res & Epidemiol BIPS, Bremen, Germany.
   [Gwozdz, W.; Reisch, L.] Copenhagen Business Sch, Dept Intercultural Commun & Management, Frederiksberg, Denmark.
   [Eiben, G.; Lissner, L.] Univ Gothenburg, Dept Publ Hlth & Community Med, Gothenburg, Sweden.
   [Fernandez-Alvira, J. M.; Moreno, L. A.] Univ Zaragoza, Dept Phys Med & Nursing, Growth Exercise Nutr & Dev GENUD Res Grp, Zaragoza, Spain.
   [De Henauw, S.] Univ Ghent, Dept Publ Hlth, Ghent, Belgium.
   [Pitsiladis, Y.] Univ Brighton, Ctr Sport & Exercise Sci & Med SESAME, Eastbourne, England.
   [Veidebaum, T.] Natl Inst Hlth Dev, Dept Chron Dis, Tallinn, Estonia.
   [Pigeot, I.] Univ Bremen, Fac Math & Comp Sci, Inst Stat, Bremen, Germany.
C3 University of Bremen; Leibniz Association; Leibniz Institute for
   Prevention Research & Epidemiology (BIPS); Copenhagen Business School;
   University of Gothenburg; University of Zaragoza; Ghent University;
   University of Brighton; National Institute for Health Development -
   Estonia; University of Bremen; Leibniz Association; Leibniz Institute
   for Prevention Research & Epidemiology (BIPS)
RP Bammann, K (corresponding author), Univ Bremen, Inst Publ Hlth & Nursing Res ipp, Fac Human & Hlth Sci, FB 11,Grazer Str 2a, D-28359 Bremen, Germany.
EM bammann@uni-bremen.de
RI Moreno, Luis/S-1780-2019; Reisch, Lucia/AAB-7589-2022; Pigeot,
   Iris/A-2722-2012; Fernández-Alvira, Juan/O-9665-2019; Yan,
   Xu/T-1427-2019; Reisch, Lucia/H-2074-2016
OI Pigeot, Iris/0000-0001-7483-0726; Bammann, Karin/0000-0002-5623-8160;
   Moreno Aznar, Luis A./0000-0003-0454-653X; Gwozdz,
   Wencke/0000-0001-7176-708X; Fernandez-Alvira, Juan
   Miguel/0000-0002-4145-5103; Pischke, Claudia/0000-0002-2256-8903;
   Pitsiladis, Yannis/0000-0001-6210-2449; Reisch,
   Lucia/0000-0002-5731-4209
FU European Community within the Sixth RTD Framework Programme [016181]
FX This work was done as part of the IDEFICS Study (www.idefics.eu). We
   gratefully acknowledge the financial support of the European Community
   within the Sixth RTD Framework Programme Contract Number 016181 (FOOD).
   We thank the IDEFICS children and their parents for their participation.
CR Ahrens W, 2011, INT J OBESITY, V35, pS3, DOI 10.1038/ijo.2011.30
   [Anonymous], 2006, ISCED 1997 - International Standard Classification of Education
   Bammann K, 2013, PEDIATR OBES, V8, P1, DOI 10.1111/j.2047-6310.2012.00075.x
   Bammann K, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0086914
   Bammann K, 2006, J PUBLIC HEALTH-HEID, V14, P279, DOI 10.1007/s10389-006-0058-0
   Baughcum AE, 2001, J DEV BEHAV PEDIATR, V22, P391, DOI 10.1097/00004703-200112000-00007
   Birch LL, 2001, PEDIATR CLIN N AM, V48, P893, DOI 10.1016/S0031-3955(05)70347-3
   Börnhorst C, 2014, CLIN NUTR, V33, P79, DOI 10.1016/j.clnu.2013.03.018
   Börnhorst C, 2013, BRIT J NUTR, V109, P1257, DOI 10.1017/S0007114512003194
   Burdette HL, 2004, ARCH PEDIAT ADOL MED, V158, P353, DOI 10.1001/archpedi.158.4.353
   Carson V, 2014, INT J OBESITY, V38, P16, DOI 10.1038/ijo.2013.135
   Cawley J, 2008, ECON HUM BIOL, V6, P388, DOI 10.1016/j.ehb.2008.06.003
   Cole TJ, 2007, BMJ-BRIT MED J, V335, P194, DOI 10.1136/bmj.39238.399444.55
   Cole TJ, 2000, BMJ-BRIT MED J, V320, P1240, DOI 10.1136/bmj.320.7244.1240
   Cullen KW, 2001, HEALTH EDUC RES, V16, P187, DOI 10.1093/her/16.2.187
   De Henauw S, 2011, INT J OBESITY, V35, pS16, DOI 10.1038/ijo.2011.31
   Development OOfEC-oa, 2008, GROW UN INC DISTR PO
   Dubois L, 2007, INT J BEHAV NUTR PHY, V4, DOI 10.1186/1479-5868-4-9
   Ekelund U, 2012, JAMA-J AM MED ASSOC, V307, P704, DOI 10.1001/jama.2012.156
   Evenson KR, 2008, J SPORT SCI, V26, P1557, DOI 10.1080/02640410802334196
   Fulton JE, 2009, AM J PREV MED, V37, pS40, DOI 10.1016/j.amepre.2009.04.010
   Gibson Rosalind S., 2005, Principles of Nutritional Assessment
   Goisis A, 2016, EUR J PUBLIC HEALTH, V26, P7, DOI 10.1093/eurpub/ckv219
   GOLDBERG GR, 1991, EUR J CLIN NUTR, V45, P569
   Goodman R, 1997, J CHILD PSYCHOL PSYC, V38, P581, DOI 10.1111/j.1469-7610.1997.tb01545.x
   Goodman R, 2001, J AM ACAD CHILD PSY, V40, P1337, DOI 10.1097/00004583-200111000-00015
   GREENLAND S, 1989, AM J PUBLIC HEALTH, V79, P340, DOI 10.2105/AJPH.79.3.340
   Harrison E., 2006, The European SocioEconomic Classification (ESeC) User Guide
   Hense S, 2013, EPIDEMIOL RES INT, V2013, DOI DOI 10.1155/2013/936365
   Hjorth P, 2014, ACTA PSYCHIAT SCAND, V130, P279, DOI 10.1111/acps.12245
   Hosmer D, 1989, Applied Logistic Regression
   Jackson C, 1998, HEALTH EDUC BEHAV, V25, P319, DOI 10.1177/109019819802500307
   Kalarchian MA, 2012, INT REV PSYCHIATR, V24, P241, DOI 10.3109/09540261.2012.678818
   Karnehed N, 2006, OBESITY, V14, P1421, DOI 10.1038/oby.2006.161
   Lobstein T, 2006, INT J PEDIATR OBES, V1, P33, DOI 10.1080/17477160600586689
   Loth K, 2014, Clin Pract (Lond), V11, P207
   Magnusson MB, 2011, PREV MED, V53, P402, DOI 10.1016/j.ypmed.2011.09.019
   Marmot M, 2013, REV EPIDEMIOL SANTE, V61, pS127, DOI 10.1016/j.respe.2013.05.014
   Mitchell JA, 2009, OBESITY, V17, P1596, DOI 10.1038/oby.2009.42
   Musher-Eizenman DR, 2009, APPETITE, V52, P89, DOI 10.1016/j.appet.2008.08.007
   Ness AR, 2007, PLOS MED, V4, P476, DOI 10.1371/journal.pmed.0040097
   Ness AR, 2006, INT J PEDIATR OBES, V1, P59, DOI 10.1080/17477160600569339
   Neumark-Sztainer D, 2014, PUBLIC HEALTH NUTR, V17, P145, DOI 10.1017/S1368980012004594
   Ojiambo R, 2012, J APPL PHYSIOL, V113, P1530, DOI 10.1152/japplphysiol.01290.2011
   Olsen NJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0078974
   Park MH, 2012, OBES REV, V13, P985, DOI 10.1111/j.1467-789X.2012.01015.x
   Peña MM, 2012, CHILD OBES, V8, P23, DOI 10.1089/chi.2011.0109
   Pietrobelli A, 2008, ANGIOLOGY, V59, p30S, DOI 10.1177/0003319708318788
   Reilly JJ, 2011, INT J OBESITY, V35, P891, DOI 10.1038/ijo.2010.222
   Reilly JJ, 2008, P NUTR SOC, V67, P317, DOI 10.1017/S0029665108008604
   Riddoch CJ, 2009, BMJ-BRIT MED J, V339, DOI 10.1136/bmj.b4544
   Sawyer MG, 2006, AMBUL PEDIATR, V6, P306, DOI 10.1016/j.ambp.2006.08.005
   Sawyer MG, 2011, PEDIATRICS, V128, P677, DOI 10.1542/peds.2010-3132
   Semmler C, 2009, OBESITY, V17, P814, DOI 10.1038/oby.2008.621
   Shrewsbury V, 2008, OBESITY, V16, P275, DOI 10.1038/oby.2007.35
   Stein D, 2014, FRONT PUBLIC HEALTH, V2, DOI 10.3389/fpubh.2014.00104
   Stomfai S, 2011, INT J OBESITY, V35, pS45, DOI 10.1038/ijo.2011.34
   Viswanath K., 2006, EXAMINING HLTH DISPA, P215
   Vollmer RL, 2013, APPETITE, V71, P232, DOI 10.1016/j.appet.2013.08.015
   Wijtzes AI, 2014, INT J BEHAV NUTR PHY, V11, DOI [10.1186/s12966-014-0096-x, 10.1186/PREACCEPT-1946502959127020]
NR 60
TC 13
Z9 15
U1 0
U2 24
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD JAN
PY 2017
VL 41
IS 1
BP 54
EP 60
DI 10.1038/ijo.2016.137
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA EK7ZG
UT WOS:000394143100007
PM 27528253
DA 2025-06-11
ER

PT J
AU Li, YS
   Fujihara, H
   Fujisawa, K
   Kawai, K
AF Li, Yun-Shan
   Fujihara, Hiroald
   Fujisawa, Koichi
   Kawai, Kazuald
TI Effects of ergothioneine on oxidative DNA damage and immune response
   induced by circadian rhythm disturbance in mice
SO JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
LA English
DT Article
DE ergothioneine; oxidative DNA damage; circadian rhythm; interleukin-6;
   8-hydroxy-2'- deoxyguanosine
ID METABOLIC SYNDROME; NIGHT; CANCER; CLOCK; RISK; PERFORMANCE; DISRUPTION;
   OBESITY; STRESS; SLEEP
AB Ergothioneine has antioxidant, anti-inflammatory, and cell-protective properties. Circadian rhythm disruption can lead to health issues, such as insomnia, mental illness, chronic diseases, and cancer. However, the impact of ergothioneine, as an antioxidant, on oxidative DNA damage and immune variations caused by circadian rhythm disruptions remains unclear. To investigate the effect of ergothioneine on oxidative DNA damage and immune responses caused by circadian rhythm disruption, 8-week-old mice were subjected to nighttime feeding and exercise restrictions for 14 days. Body weight, daytime running wheel activity, and anxiety-like behavior showed no significant differences between the night-restricted groups, regardless of ergothioneine administration. Serum interleukin-6 levels, 8hydroxy-2'-deoxyguanosine levels in urine and nuclear DNA of the liver, testes, lungs, and pancreas were significantly reduced in the night-restricted group receiving ergothioneine compared with that of the group without ergothioneine, with no significant differences observed when compared to the control group. Ergothioneine can mitigate immune function changes and oxidative DNA damage induced by circadian rhythm disruption caused by abnormal dietary timing in mice. However, it did not alleviate obesity or mental state dysregulation. These findings have important implications for improving nightshift workers health and developing therapies for diseases associated with circadian rhythm disturbances.
C1 [Li, Yun-Shan; Fujisawa, Koichi; Kawai, Kazuald] Univ Occupat & Environm Hlth, Dept Environm Oncol, Kitakyushu 8078555, Japan.
   [Fujihara, Hiroald] Univ Occupat & Environm Hlth, Dept Ergon, Kitakyushu 8078555, Japan.
   [Li, Yun-Shan] Univ Occupat & Environm Hlth, Ctr Stress Related Dis Control & Prevent, Kitakyushu 8078555, Japan.
C3 University of Occupational & Environmental Health - Japan; University of
   Occupational & Environmental Health - Japan; University of Occupational
   & Environmental Health - Japan
RP Li, YS (corresponding author), Univ Occupat & Environm Hlth, Dept Environm Oncol, Kitakyushu 8078555, Japan.; Li, YS (corresponding author), Univ Occupat & Environm Hlth, Ctr Stress Related Dis Control & Prevent, Kitakyushu 8078555, Japan.
EM liyunsha@med.uoeh-u.ac.jp
FU JSPS KAKENHI [JP21K06660]
FX <B>Acknowledgements</B> This work was supported by JSPS KAKENHI (grant
   number: JP21K06660) .
CR Adams KL, 2013, J BIOL RHYTHM, V28, P272, DOI 10.1177/0748730413494561
   Arafa A, 2021, J EPIDEMIOL, V31, P585, DOI 10.2188/jea.JE20200208
   Arble DM, 2009, OBESITY, V17, P2100, DOI 10.1038/oby.2009.264
   Borodina I, 2020, NUTR RES REV, V33, P190, DOI 10.1017/S0954422419000301
   Budkowska M, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms232214275
   Calvo MS, 2016, PLANT FOOD HUM NUTR, V71, P245, DOI 10.1007/s11130-016-0552-7
   Chaix A, 2014, CELL METAB, V20, P991, DOI 10.1016/j.cmet.2014.11.001
   Cheah IK, 2021, REDOX BIOL, V42, DOI 10.1016/j.redox.2021.101868
   Dare A., 2019, IOSR Journal of Pharmacy and Biological Sciences, V14, P6
   Dare A, 2021, CAN J PHYSIOL PHARM, V99, P1137, DOI 10.1139/cjpp-2021-0247
   DAVIES MH, 1983, TOXICOL LETT, V19, P23, DOI 10.1016/0378-4274(83)90257-6
   Demirkol MK, 2021, ANDROLOGIA, V53, DOI 10.1111/and.14116
   DIAZMUNOZ M, 1985, NEUROSCIENCE, V16, P859, DOI 10.1016/0306-4522(85)90100-9
   Ey J, 2007, J AGR FOOD CHEM, V55, P6466, DOI 10.1021/jf071328f
   Fishbein AB, 2021, J CLIN INVEST, V131, DOI 10.1172/JCI148286
   Fu TT, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.850813
   Gao YJ, 2022, ACS OMEGA, V7, P21554, DOI 10.1021/acsomega.2c01350
   Halliwell B, 2023, ANNU REV FOOD SCI T, V14, P323, DOI 10.1146/annurev-food-060822-122236
   Halliwell B, 2018, FEBS LETT, V592, P3357, DOI 10.1002/1873-3468.13123
   Iqbal S, 2023, HUM EXP TOXICOL, V42, DOI 10.1177/09603271231178015
   Jerigova V, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms232213722
   Kato Y, 2010, PHARM RES-DORDR, V27, P832, DOI 10.1007/s11095-010-0076-z
   Katsube M, 2024, GEROSCIENCE, V46, P3889, DOI 10.1007/s11357-024-01111-5
   Kettner NM, 2015, CELL METAB, V22, P448, DOI 10.1016/j.cmet.2015.06.005
   Kim Y, 2007, GENES IMMUN, V8, P369, DOI 10.1038/sj.gene.6364394
   LEE EHY, 1987, PSYCHOPHARMACOLOGY, V93, P320
   Li YS, 2025, J CLIN BIOCHEM NUTR, V76, P135, DOI 10.3164/jcbn.24-126
   Li YS, 2018, J CLIN BIOCHEM NUTR, V62, P238, DOI 10.3164/jcbn.17-70
   Li YS, 2017, J CLIN BIOCHEM NUTR, V61, P14, DOI 10.3164/jcbn.16-80
   MAYUMI T, 1978, CHEM PHARM BULL, V26, P3772
   McHill AW, 2017, OBES REV, V18, P15, DOI 10.1111/obr.12503
   Monje FJ, 2011, J NEUROSCI, V31, P9075, DOI 10.1523/JNEUROSCI.1537-11.2011
   Mukherji A, 2015, P NATL ACAD SCI USA, V112, pE6683, DOI 10.1073/pnas.1519735112
   Mukherji A, 2015, P NATL ACAD SCI USA, V112, pE6691, DOI 10.1073/pnas.1519807112
   Nakamichi N, 2016, BRAIN BEHAV, V6, DOI 10.1002/brb3.477
   Nikolic VN, 2013, J CARDIOL, V62, P37, DOI 10.1016/j.jjcc.2013.02.013
   Paul BD, 2010, CELL DEATH DIFFER, V17, P1134, DOI 10.1038/cdd.2009.163
   Pavanello S, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/8327629
   Piriyaprasath K, 2023, NUTRIENTS, V15, DOI 10.3390/nu15183989
   Prut L, 2003, EUR J PHARMACOL, V463, P3, DOI 10.1016/S0014-2999(03)01272-X
   Qian J, 2022, P NATL ACAD SCI USA, V119, DOI 10.1073/pnas.2206348119
   Reuter S, 2010, FREE RADICAL BIO MED, V49, P1603, DOI 10.1016/j.freeradbiomed.2010.09.006
   Rutter J, 2001, SCIENCE, V293, P510, DOI 10.1126/science.1060698
   Salama SA, 2021, J BIOCHEM MOL TOXIC, V35, DOI 10.1002/jbt.22729
   Sasayama D, 2013, J PSYCHIATR RES, V47, P401, DOI 10.1016/j.jpsychires.2012.12.001
   Scheer FAJL, 2009, P NATL ACAD SCI USA, V106, P4453, DOI 10.1073/pnas.0808180106
   Schernhammer ES, 2013, AM J EPIDEMIOL, V178, P1434, DOI 10.1093/aje/kwt155
   Sharifian Akbar, 2005, J Circadian Rhythms, V3, P15, DOI 10.1186/1740-3391-3-15
   Tang RMY, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-20021-z
   Tian XY, 2023, BRIT J NUTR, V129, P104, DOI 10.1017/S0007114522003592
   Tomás-Zapico C, 2003, J PINEAL RES, V34, P60, DOI 10.1034/j.1600-079X.2003.02951.x
   Turek FW, 2005, SCIENCE, V308, P1043, DOI 10.1126/science.1108750
   Vgontzas AN, 2007, AM J PHYSIOL-ENDOC M, V292, pE253, DOI 10.1152/ajpendo.00651.2005
   Wang Z, 2023, INT IMMUNOPHARMACOL, V119, DOI 10.1016/j.intimp.2023.110211
   Xiao Q, 2021, CANCER RES, V81, P1616, DOI 10.1158/0008-5472.CAN-20-2256
NR 55
TC 0
Z9 0
U1 12
U2 12
PU JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
PI KYOTO
PA KYOTO PREFECTURAL UNIV MED, GRAD SCH MEDICAL SCIENCE, DEPT MOLECULAR
   GASTROENTEROLOGY & HEPATOLOGY, KYOTO, 602-8566, JAPAN
SN 0912-0009
EI 1880-5086
J9 J CLIN BIOCHEM NUTR
JI J. Clin. Biochem. Nutr.
PD MAR
PY 2025
VL 76
IS 2
BP 117
EP 124
DI 10.3164/jcbn.24-220
EA DEC 2024
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA Y9S6G
UT WOS:001382803100001
PM 40151407
OA gold
DA 2025-06-11
ER

PT J
AU Mansueto, P
   Seidita, A
   Vitale, G
   Gangemi, S
   Iaria, C
   Cascio, A
AF Mansueto, Pasquale
   Seidita, Aurelio
   Vitale, Giustina
   Gangemi, Sebastiano
   Iaria, Chiara
   Cascio, Antonio
TI Vitamin D Deficiency in HIV Infection: Not Only a Bone Disorder
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Review
ID HEPATITIS-C VIRUS; 25-HYDROXYVITAMIN D CONCENTRATIONS; ACTIVE
   ANTIRETROVIRAL THERAPY; WOMENS INTERAGENCY HIV; INTIMA-MEDIA THICKNESS;
   D INSUFFICIENCY; D SUPPLEMENTATION; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; IMMUNE ACTIVATION
AB Hypovitaminosis D is a worldwide disorder, with a high prevalence in the general population of both Western and developing countries. In HIV patients, several studies have linked vitamin D status with bone disease, neurocognitive impairment, depression, cardiovascular disease, high blood pressure, metabolic syndrome, type 2 diabetes mellitus, infections, autoimmune diseases like type 1 diabetesmellitus, and cancer. In this review, we focus on the most recent epidemiological and experimental data dealing with the relationship between vitamin D deficiency and HIV infection. We analysed the extent of the problem, pathogenic mechanisms, clinical implications, and potential benefits of vitamin D supplementation in HIV-infected subjects.
C1 [Mansueto, Pasquale; Seidita, Aurelio; Vitale, Giustina] Univ Palermo, Dept Internal Med & Biomed, I-90100 Palermo, Italy.
   [Gangemi, Sebastiano; Cascio, Antonio] Univ Messina, Dept Human Pathol, I-98125 Messina, Italy.
   [Gangemi, Sebastiano] IFC CNR, Messina Unit, I-98100 Messina, Italy.
   [Iaria, Chiara] Papardo Piemonte Hosp, Infectious Dis Unit, I-98125 Messina, Italy.
   [Cascio, Antonio] Univ Messina, AILMI ONLUS Italian Assoc Control Infect Dis, I-98125 Messina, Italy.
C3 University of Palermo; University of Messina; Consiglio Nazionale delle
   Ricerche (CNR); Istituto di Fisiologia Clinica (IFC-CNR); University of
   Messina
RP Cascio, A (corresponding author), Univ Messina, Dept Human Pathol, I-98125 Messina, Italy.
EM acascio@unime.it
RI gangemi, sebastiano/GLR-3109-2022; Mansueto, Pasquale/K-3458-2016;
   Seidita, Aurelio/IQT-5629-2023; Cascio, Antonio/K-5453-2016
OI Mansueto, Pasquale/0000-0002-0406-0583; Seidita,
   Aurelio/0000-0003-4080-2641; Cascio, Antonio/0000-0002-1992-1796; Iaria,
   Chiara/0000-0002-5477-9887; gangemi, sebastiano/0000-0001-7001-6532
CR Aberg Judith A, 2012, Top Antivir Med, V20, P101
   Abramovitch S, 2011, GUT, V60, P1728, DOI 10.1136/gut.2010.234666
   Abu-Mouch S, 2011, WORLD J GASTROENTERO, V17, P5184, DOI 10.3748/wjg.v17.i47.5184
   Adeyemi OM, 2013, AIDS PATIENT CARE ST, V27, P320, DOI 10.1089/apc.2012.0400
   Anderson JL, 2010, AM J CARDIOL, V106, P963, DOI 10.1016/j.amjcard.2010.05.027
   Appay V, 2008, J PATHOL, V214, P231, DOI 10.1002/path.2276
   Armstrong GL, 2006, ANN INTERN MED, V144, P705, DOI 10.7326/0003-4819-144-10-200605160-00004
   Arpadi SM, 2009, PEDIATRICS, V123, pE121, DOI 10.1542/peds.2008-0176
   Aziz M, 2013, AIDS, V27, P573, DOI 10.1097/QAD.0b013e32835b9ba1
   Bakhru A, 2010, GYNECOL ONCOL, V119, P314, DOI 10.1016/j.ygyno.2010.07.006
   Biron A, 2012, AIDS RES HUM RETROV, V28, P1672, DOI [10.1089/aid.2012.0048, 10.1089/AID.2012.0048]
   Borges AH, 2013, AIDS, V27, P1433, DOI 10.1097/QAD.0b013e32835f6b0c
   Bozzette SA, 2003, NEW ENGL J MED, V348, P702, DOI 10.1056/NEJMoa022048
   Branch AD, 2013, AM J CLIN NUTR, V98, P423, DOI 10.3945/ajcn.112.048785
   Brown TT, 2010, ANTIVIR THER, V15, P425, DOI [10.3851/IMP15021, 10.3851/IMP1502]
   CHERUBIN CE, 1993, ANN INTERN MED, V119, P1017, DOI 10.7326/0003-4819-119-10-199311150-00009
   Choi AI, 2011, CLIN INFECT DIS, V52, P941, DOI 10.1093/cid/ciq239
   Chung M, 2011, ANN INTERN MED, V155, P827, DOI 10.7326/0003-4819-155-12-201112200-00005
   Collazos J, 2011, CURR HIV RES, V9, P339, DOI 10.2174/157016211797635982
   Colston KW, 2006, ANTICANCER RES, V26, P2573
   CONNOR RI, 1991, BIOCHEM BIOPH RES CO, V176, P852, DOI 10.1016/S0006-291X(05)80264-5
   Crowe SM, 2010, J LEUKOCYTE BIOL, V87, P589, DOI 10.1189/jlb.0809580
   Dao CN, 2011, CLIN INFECT DIS, V52, P396, DOI 10.1093/cid/ciq158
   De Luca A, 2013, BMC INFECT DIS, V13, DOI 10.1186/1471-2334-13-414
   Deeks SG, 2013, LANCET, V382, P1525, DOI 10.1016/S0140-6736(13)61809-7
   Duprez DA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0044454
   Eckard AR, 2013, AIDS RES HUM RETROV, V29, P1224, DOI [10.1089/AID.2012.0384, 10.1089/aid.2012.0384]
   Ellfolk M, 2009, MOL PHARMACOL, V75, P1392, DOI 10.1124/mol.108.053660
   Erlandson KM, 2014, INT J INFECT DIS, V24, P6, DOI 10.1016/j.ijid.2014.02.006
   Ettinger AS, 2009, ENVIRON HEALTH PERSP, V117, P26, DOI [10.1289/ehp.11868, 10.1289/ehp.1171c26]
   Farnik H, 2013, HEPATOLOGY, V58, P1270, DOI 10.1002/hep.26488
   French MA, 2009, J INFECT DIS, V200, P1212, DOI 10.1086/605890
   Friis-Moller N, 2003, AIDS, V17, P1179, DOI 10.1097/00002030-200305230-00010
   Friis-Moller N, 2007, NEW ENGL J MED, V356, P1723, DOI 10.1056/NEJMoa062744
   Funderburg NT, 2014, CURR OPIN HIV AIDS, V9, P80, DOI 10.1097/COH.0000000000000019
   Gal-Tanamy M, 2011, HEPATOLOGY, V54, P1570, DOI 10.1002/hep.24575
   Galli M, 2002, J ACQ IMMUN DEF SYND, V29, P21, DOI 10.1097/00126334-200201010-00003
   Gedela K, 2014, INT J STD AIDS, V25, P488, DOI 10.1177/0956462413515194
   Giacomet V, 2013, HIV CLIN TRIALS, V14, P51, DOI 10.1310/hct1402-51
   Gibney KB, 2008, CLIN INFECT DIS, V46, P443, DOI 10.1086/525268
   Groleau V, 2013, J PEDIATR GASTR NUTR, V56, P316, DOI 10.1097/MPG.0b013e3182758c4a
   Grunfeld C, 2009, AIDS, V23, P1841, DOI 10.1097/QAD.0b013e32832d3b85
   Guidi M., 2014, ANTIVIRAL THERAPY
   Hariparsad N, 2004, J CLIN PHARMACOL, V44, P1273, DOI 10.1177/0091270004269142
   HAUG C, 1994, J INFECT DIS, V169, P889, DOI 10.1093/infdis/169.4.889
   Havers F, 2014, J INFECT DIS, V210, P244, DOI 10.1093/infdis/jiu259
   Hearps AC, 2014, CURR HIV-AIDS REP, V11, P20, DOI 10.1007/s11904-013-0190-8
   Holick MF, 2007, NEW ENGL J MED, V357, P266, DOI 10.1056/NEJMra070553
   Hsue PY, 2009, AIDS, V23, P1059, DOI 10.1097/QAD.0b013e32832b514b
   Hull MW, 2012, AIDS, V26, P1789, DOI 10.1097/QAD.0b013e32835612ce
   Kahn LS, 2011, J NATL MED ASSOC, V103, P407, DOI 10.1016/S0027-9684(15)30337-0
   Kakalia S, 2011, J PEDIATR-US, V159, P951, DOI 10.1016/j.jpeds.2011.06.010
   Khan H, 2013, P NUTR SOC, V72, P89, DOI 10.1017/S0029665112002765
   Kondo Y, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0063672
   Lai H, 2013, VASC HEALTH RISK MAN, V9, P729, DOI 10.2147/VHRM.S50537
   Lake JE, 2013, LANCET INFECT DIS, V13, P964, DOI 10.1016/S1473-3099(13)70271-8
   Lambert AA, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0095802
   Lawn SD, 2002, MICROBES INFECT, V4, P635, DOI 10.1016/S1286-4579(02)01582-4
   Longenecker CT, 2012, ANTIVIR THER, V17, P613, DOI 10.3851/IMP1983
   Maartens G, 2014, LANCET, V384, P258, DOI 10.1016/S0140-6736(14)60164-1
   Mandorfer M, 2013, AIDS, V27, P227, DOI 10.1097/QAD.0b013e32835aa161
   Martineau AR, 2011, LANCET, V377, P242, DOI 10.1016/S0140-6736(10)61889-2
   McComsey GA, 2010, CLIN INFECT DIS, V51, P937, DOI 10.1086/656412
   Mehta S, 2011, AIDS PATIENT CARE ST, V25, P579, DOI 10.1089/apc.2011.0182
   Mehta S, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008770
   Milazzo L, 2011, CURR HIV RES, V9, P186, DOI 10.2174/157016211795945269
   Mizoue T, 2008, CANCER EPIDEM BIOMAR, V17, P2800, DOI 10.1158/1055-9965.EPI-08-0369
   Murray CJL, 2014, LANCET, V384, P1005, DOI 10.1016/S0140-6736(14)60844-8
   National Center for Health Statistics. Centers for disease control and prevention, 2014, NAT HLTH NUTR EX SUR
   Nixon DE, 2010, CURR OPIN HIV AIDS, V5, P498, DOI 10.1097/COH.0b013e32833ed6f4
   Nnoaham KE, 2008, INT J EPIDEMIOL, V37, P113, DOI 10.1093/ije/dym247
   Ostrowski SR, 2008, SCAND J IMMUNOL, V68, P652, DOI 10.1111/j.1365-3083.2008.02184.x
   Palella FJ, 2006, JAIDS-J ACQ IMM DEF, V43, P27, DOI 10.1097/01.qai.0000233310.90484.16
   Pittas AG, 2010, ANN INTERN MED, V152, P307, DOI 10.7326/0003-4819-152-5-201003020-00009
   Portilla J, 2014, J INT AIDS SOC, V17, DOI 10.7448/IAS.17.1.18945
   Rasmussen TA, 2014, LANCET HIV, V1, pE13, DOI 10.1016/S2352-3018(14)70014-1
   Rathored J, 2012, INT J TUBERC LUNG D, V16, P1522, DOI 10.5588/ijtld.12.0122
   Ross AC, 2011, ANTIVIR THER, V16, P555, DOI 10.3851/IMP1784
   Santoro D, 2014, NUTRIENTS, V6, P1029, DOI 10.3390/nu6031029
   SCHUITEMAKER H, 1992, J CLIN INVEST, V89, P1154, DOI 10.1172/JCI115697
   Schwartz GG, 2009, ANN EPIDEMIOL, V19, P96, DOI 10.1016/j.annepidem.2008.03.007
   Sherwood JE, 2012, CLIN INFECT DIS, V55, P1727, DOI 10.1093/cid/cis785
   Sudfeld CR, 2013, J INFECT DIS, V207, P378, DOI 10.1093/infdis/jis693
   Szep Z, 2011, AIDS, V25, P525, DOI 10.1097/QAD.0b013e328342fdfd
   Tebas P, 2008, JAIDS-J ACQ IMM DEF, V49, pS86, DOI 10.1097/QAI.0b013e31818651e6
   Teichmann J, 2000, METABOLISM, V49, P1134, DOI 10.1053/meta.2000.8609
   Thein HH, 2008, AIDS, V22, P1979, DOI 10.1097/QAD.0b013e32830e6d51
   Theodorou M, 2014, CLIN NUTR, V33, P274, DOI 10.1016/j.clnu.2013.04.018
   Torriani FJ, 2004, NEW ENGL J MED, V351, P438, DOI 10.1056/NEJMoa040842
   Triant VA, 2013, CURR HIV-AIDS REP, V10, P199, DOI 10.1007/s11904-013-0168-6
   Vaidya A, 2012, METABOLISM, V61, P450, DOI 10.1016/j.metabol.2011.09.007
   van den Bout-van den Beukel CJP, 2008, HIV MED, V9, P771, DOI 10.1111/j.1468-1293.2008.00630.x
   Vecchi VL, 2012, BMC INFECT DIS, V12, DOI 10.1186/1471-2334-12-192
   Viard JP, 2011, AIDS, V25, P1305, DOI 10.1097/QAD.0b013e328347f6f7
   Villar LM, 2013, WORLD J GASTROENTERO, V19, P5917, DOI 10.3748/wjg.v19.i35.5917
   Wasserman P, 2010, AIDS PATIENT CARE ST, V24, P223, DOI 10.1089/apc.2009.0241
   Watts DH, 2006, DRUG SAFETY, V29, P467, DOI 10.2165/00002018-200629060-00002
   Wohl DA, 2014, ANTIVIR THER, V19, P191, DOI 10.3851/IMP2721
NR 98
TC 77
Z9 83
U1 1
U2 4
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2015
VL 2015
AR 735615
DI 10.1155/2015/735615
PG 18
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA CH8OA
UT WOS:000354294500001
PM 26000302
OA hybrid, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Yang, TZ
   Yang, XZY
   Yu, LW
   Cottrell, RR
   Jiang, SH
AF Yang, Tingzhong
   Yang, Xiaozhao Y.
   Yu, Lingwei
   Cottrell, Randall R.
   Jiang, Shuhan
TI Individual and regional association between socioeconomic status and
   uncertainty stress, and life stress: a representative nationwide study
   of China
SO INTERNATIONAL JOURNAL FOR EQUITY IN HEALTH
LA English
DT Article
DE Socioeconomic status (SES); Life stress; Uncertainty stress; College
   students; Regional variance; China
ID METABOLIC SYNDROME; SOCIAL-STATUS; HEALTH; INEQUALITIES
AB Background: Many studies have examined the association between socioeconomic status (SES) and mental stress. Uncertainty stress is a prominent aspect of mental stress. Yet no research has ever empirically analyzed the impact of SES on uncertainty stress.
   Methods: Students were identified through a multistage survey sampling process including 50 universities. Each student participant completed the Global Health Professions Student Survey (GHPSS) on Tobacco Control in China. Regional variables were retrieved from the National Bureau of Statistics database. Both unadjusted and adjusted methods were considered in the analyses.
   Results: Among the 11,942 participants, severe uncertainty stress prevalence was 19.6%, while severe life stress prevalence was 8.6%. Multilevel logistic regression showed that most SES variables were associated with uncertainty stress. Students with "operation and commercial work" as mother's occupation and "rural or township" as family location exhibited a higher prevalence of severe uncertainty stress. Lower family income and original region gross domestic products (GDP) were also associated with higher severe uncertainty stress prevalence. However, only father's occupation was correlated with life stress.
   Conclusions: Based on the literature review, this is the first empirical study examining the impact of SES on uncertainty stress in China and elsewhere in the world. Our research underscores the importance of decreasing socioeconomic inequalities in controlling excessive uncertainty stress.
C1 [Yang, Tingzhong; Yu, Lingwei; Jiang, Shuhan] Zhejiang Univ, Sch Med, Dept Social Med, Ctr Tobacco Control Res, Hangzhou 310058, Zhejiang, Peoples R China.
   [Yang, Xiaozhao Y.] Murray State Univ, Dept Polit Sci & Sociol, Murray, KY 42701 USA.
   [Cottrell, Randall R.] Univ North Carolina Wilmington, Publ Hlth Studies Program, Wilmington, NC 28403 USA.
C3 Zhejiang University; Murray State University; University of North
   Carolina; University of North Carolina Wilmington
RP Yang, TZ (corresponding author), Zhejiang Univ, Sch Med, Dept Social Med, Ctr Tobacco Control Res, Hangzhou 310058, Zhejiang, Peoples R China.
EM Tingzhongyang@zju.edu.cn
RI Yang, Xiaozhao/AAH-5836-2019; jiang, shuhan/AAR-7378-2021
OI Yang, Xiaozhao/0000-0001-7354-7208
FU National Nature Science Foundation of China [71,490,733, 71473221];
   Global Bridges/IGLC [2014SC1]
FX This study was partly funded by the National Nature Science Foundation
   of China (Major Project, 71,490,733), the National Nature Science
   Foundation of China (71473221) and Global Bridges/IGLC, 2014SC1).
CR [Anonymous], COMMUNICATION
   [Anonymous], 2008, MECHANOBIOLOGY HLTH
   [Anonymous], 1980, CULTURES CONSEQUENCE
   [Anonymous], 2007, HLTH BEHAV THEORY RE
   Blau P., 1964, EXCHANGE POWER SOC
   Cui XB, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-979
   Department of Comprehensive Statistics of National Economy Rural Social and Economic Research Division National Bureau of Statistics, 2007, CHIN STAT YB REG EC
   Dubuc C, 2013, ETHOLOGY, V119, P1006, DOI 10.1111/eth.12146
   Gallo LC, 2003, PSYCHOL BULL, V129, P10, DOI 10.1037//0033-2909.129.1.10
   Greco V, 2003, PERS INDIV DIFFER, V34, P1057, DOI 10.1016/S0191-8869(02)00091-0
   Huang IC, 1998, SOC BEHAV PERSONAL, V26, P181, DOI 10.2224/sbp.1998.26.2.181
   Lynch JW, 2000, Social Epidemiology, P13
   Macleod J, 2005, SOC SCI MED, V61, P1916, DOI 10.1016/j.socscimed.2005.04.009
   Markwick A, 2014, INT J EQUITY HEALTH, V13, DOI 10.1186/s12939-014-0091-5
   Matthews KA, 2008, HEALTH PSYCHOL, V27, P576, DOI 10.1037/0278-6133.27.5.576
   MIROWSKY J, 1990, J HEALTH SOC BEHAV, V31, P71, DOI 10.2307/2137046
   Mishel M H, 1988, Image J Nurs Sch, V20, P225, DOI 10.1111/j.1547-5069.1988.tb00082.x
   MONROE SM, 1991, PSYCHOL BULL, V110, P406, DOI 10.1037/0033-2909.110.3.406
   Pajo E., 2008, International migration, social demotion, and imagined advancement: An ethnography of socioglobal mobility
   Prescott E, 2007, EUR J CARDIOV PREV R, V14, P405, DOI 10.1097/HJR.0b013e32800ff169
   Sapolsky RM, 2005, SCIENCE, V308, P648, DOI 10.1126/science.1106477
   Shaver P.R., 2012, Meaning, mortality, and choice: The social psychology of existential concerns Meaning, mortality, and choice: The social psychology of existential concerns, P438
   Sorokin P.A., 1959, SOCIAL CULTURAL MOBI, V4
   THOITS PA, 1987, J HEALTH SOC BEHAV, V28, P7, DOI 10.2307/2137137
   Wang HM, 2015, INT J EQUITY HEALTH, V14, DOI 10.1186/s12939-015-0152-4
   Warren CW, 2008, TOB CONTROL, V17, DOI 10.1136/tc.2007.023895
   Wight R.G., 2008, Stress processes across the life course, P369, DOI DOI 10.1016/S1040-2608(08)00014-2
   Wu D, 2016, J AFFECT DISORDERS, V202, P137, DOI 10.1016/j.jad.2016.05.030
   Yang N. X., 2018, EMPLOYMENT COLL STUD, V2, P16
   Yang TZ, 2015, AM J HEALTH BEHAV, V39, P732, DOI 10.5993/AJHB.39.5.14
   Yang TZ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048971
   [杨廷忠 YANG Tingzhong], 2007, [中国行为医学科学, Chinese Journal of Behavioral Medical Science], V16, P331
   Yang XY, 2016, ARCH SEX BEHAV, V45, P997, DOI 10.1007/s10508-015-0584-3
   ZAKOWSKI SG, 1995, PSYCHOL HEALTH, V10, P409, DOI 10.1080/08870449508401960
NR 34
TC 34
Z9 38
U1 4
U2 41
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-9276
J9 INT J EQUITY HEALTH
JI Int. J. Equity Health
PD JUL 5
PY 2017
VL 16
AR 118
DI 10.1186/s12939-017-0618-7
PG 8
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA FA8GY
UT WOS:000405685400001
PM 28679409
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wicks, SE
   Nguyen, TT
   Breaux, C
   Kruger, C
   Stadler, K
AF Wicks, Shawna E.
   Nguyen, Trang-Tiffany
   Breaux, Chelsea
   Kruger, Claudia
   Stadler, Krisztian
TI Diet-induced obesity and kidney disease - In search of a susceptible
   mouse model
SO BIOCHIMIE
LA English
DT Article
DE Obesity; Chronic kidney disease; Mouse models; High fat diet; Oxidative
   stress
ID HIGH-FAT DIET; INSULIN-RESISTANCE; DIABETIC-NEPHROPATHY; METABOLIC
   SYNDROME; OXIDATIVE STRESS; FUNCTIONAL-CHANGES; NITRIC-OXIDE; US ADULTS;
   PODOCYTE; MICE
AB Obesity and metabolic syndrome are independent risk factors for chronic kidney disease, even without diabetes or hyperglycemia.
   Here, we compare two mouse models that are susceptible to diet-induced obesity: the relatively renal injury resistant C57BL/6J strain and the DBA2/J strain which is more sensitive to renal injury. Our studies focused on characterizing the effects of high fat diet feeding on renal oxidative stress, albuminuria, fibrosis and podocyte loss/insulin resistance. While the C57BL/6J strain does not develop significant pathological changes in the kidney, at least on lard based diets within the time frame investigated, it does show increased renal iNOS and nitrotyrosine levels and elevated mitochondrial respiration which may be indicative of mitochondrial lipid overfueling. Restricting the high fat diet to decrease adiposity decreased the levels of cellular oxidative stress markers, indicating that adiposity-related proinflammatory changes such as increased iNOS levels may trigger similar responses in the kidney. Mitochondrial respiration remained higher, suggesting that eating excess lipids, despite normal adiposity may still lead to renal mitochondrial overfueling. In comparison, DBA/2J mice developed albuminuria on similar diets, signs of fibrosis, oxidative stress, early signs of podocyte loss (evaluated by the markers podocin and WT-1) and podocyte insulin resistance (unable to phosphorylate their glomerular Akt when insulin was given). To summarize, while the C57BL/6J strain is not particularly susceptible to renal disease, changes in its mitochondrial lipid handling combined with the easy availability of transgenic technology may be an advantage to design new knockout models related to mitochondrial lipid metabolism. The DBA/2J model could serve as a basis for studying podocyte insulin resistance and identifying early renal markers in obesity before more severe kidney disease develops. Based on our observations, we encourage further critical evaluation of mouse models for obesity related chronic kidney disease. (C) 2015 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
C1 [Nguyen, Trang-Tiffany; Breaux, Chelsea; Kruger, Claudia; Stadler, Krisztian] Pennington Biomed Res Ctr, Oxidat Stress & Dis Lab, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
   [Wicks, Shawna E.] Pennington Biomed Res Ctr, Gene Nutrient Interact Lab, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center; Louisiana State University
   System; Louisiana State University; Pennington Biomedical Research
   Center
RP Stadler, K (corresponding author), Pennington Biomed Res Ctr, Oxidat Stress & Dis Lab, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM krisztian.stadler@pbrc.edu
RI Stadler, Krisztian/N-1992-2017
FU NORC Pilot and Feasibility Award [NIH P30DK072476]; DiaComp Pilot and
   Feasibility Award [14GHSU1393]; NORC; COBRE [NIH P20-RR021945,
   P30-DK072476]; T32 Fellowship Award [T32 AT004094]
FX Research contributing to this manuscript from the Stadler lab was
   partially supported by a NORC Pilot and Feasibility Award (through NIH
   P30DK072476) and a DiaComp Pilot and Feasibility Award (14GHSU1393,
   K.S.). Confocal images were taken at the Pennington Cell Biology and
   Imaging Core, supported by the NORC and COBRE Grants (NIH P20-RR021945
   and P30-DK072476). S.W. was supported by a T32 Fellowship Award (T32
   AT004094).
CR Abrass CK, 2004, J AM SOC NEPHROL, V15, P2768, DOI 10.1097/01.ASN.0000141963.04540.3E
   Bagby SP, 2004, J AM SOC NEPHROL, V15, P2775, DOI 10.1097/01.ASN.0000141965.28037.EE
   Brosius FC, 2009, J AM SOC NEPHROL, V20, P2503, DOI 10.1681/ASN.2009070721
   Chen J, 2003, J AM SOC NEPHROL, V14, P469, DOI 10.1097/01.ASN.0000046029.53933.09
   Chen J, 2004, ANN INTERN MED, V140, P167, DOI 10.7326/0003-4819-140-3-200402030-00007
   Coresh J, 2007, JAMA-J AM MED ASSOC, V298, P2038, DOI 10.1001/jama.298.17.2038
   Declèves AE, 2015, CURR OPIN NEPHROL HY, V24, P28, DOI 10.1097/MNH.0000000000000087
   Declèves AE, 2011, J AM SOC NEPHROL, V22, P1846, DOI 10.1681/ASN.2011010026
   Deji N, 2009, AM J PHYSIOL-RENAL, V296, pF118, DOI 10.1152/ajprenal.00110.2008
   Dugan LL, 2013, J CLIN INVEST, V123, P4888, DOI 10.1172/JCI66218
   Forbes JM, 2008, DIABETES, V57, P1446, DOI 10.2337/db08-0057
   Fornoni A, 2010, NEW ENGL J MED, V363, P2068, DOI 10.1056/NEJMcibr1008395
   George B, 2011, AM J PHYSIOL-RENAL, V300, pF1152, DOI 10.1152/ajprenal.00373.2010
   Gödel M, 2011, J CLIN INVEST, V121, P2197, DOI 10.1172/JCI44774
   Guo G, 2004, J AM SOC NEPHROL, V15, P2851, DOI 10.1097/01.ASN.0000143474.91362.C4
   Henegar JR, 2001, J AM SOC NEPHROL, V12, P1211, DOI 10.1681/ASN.V1261211
   Hotamisligil GS, 2008, NAT REV IMMUNOL, V8, P923, DOI 10.1038/nri2449
   Ischiropoulos H, 1998, ARCH BIOCHEM BIOPHYS, V356, P1, DOI 10.1006/abbi.1998.0755
   Ix JH, 2010, J AM SOC NEPHROL, V21, P406, DOI 10.1681/ASN.2009080820
   Jiang T, 2005, J BIOL CHEM, V280, P32317, DOI 10.1074/jbc.M500801200
   Koves TR, 2008, CELL METAB, V7, P45, DOI 10.1016/j.cmet.2007.10.013
   Kramer H, 2005, AM J KIDNEY DIS, V46, P587, DOI 10.1053/j.ajkd.2005.06.007
   Marette A, 2002, CURR OPIN CLIN NUTR, V5, P377, DOI 10.1097/00075197-200207000-00005
   Muoio DM, 2006, ANNU REV BIOCHEM, V75, P367, DOI 10.1146/annurev.biochem.75.103004.142512
   Muoio DM, 2012, CELL METAB, V15, P595, DOI 10.1016/j.cmet.2012.04.010
   Palaniappan L, 2003, AM J HYPERTENS, V16, P952, DOI 10.1016/S0895-7061(03)01009-4
   Perreault M, 2001, NAT MED, V7, P1138, DOI 10.1038/nm1001-1138
   RANDLE PJ, 1963, LANCET, V1, P785
   Rossmeisl M, 2003, DIABETES, V52, P1958, DOI 10.2337/diabetes.52.8.1958
   Ruggiero C, 2011, AM J PHYSIOL-ENDOC M, V300, pE1047, DOI 10.1152/ajpendo.00666.2010
   Sharma K, 2014, KIDNEY INT SUPPL, V4, P113, DOI 10.1038/kisup.2014.21
   Susztak K, 2006, DIABETES, V55, P225, DOI 10.2337/diabetes.55.1.225
   Szabo C, 2007, NAT REV DRUG DISCOV, V6, P662, DOI 10.1038/nrd2222
   Tejada T, 2008, KIDNEY INT, V73, P1385, DOI 10.1038/ki.2008.109
   Ton ALY, 2007, SEMIN NEPHROL, V27, P130, DOI 10.1016/j.semnephrol.2007.01.006
   Wang XX, 2009, AM J PHYSIOL-RENAL, V297, pF1587, DOI 10.1152/ajprenal.00404.2009
   Wei P, 2004, DIABETOLOGIA, V47, P1541, DOI 10.1007/s00125-004-1489-1
   Weinberg JM, 2011, J AM SOC NEPHROL, V22, P431, DOI 10.1681/ASN.2010060643
   Welsh GI, 2010, CELL METAB, V12, P329, DOI 10.1016/j.cmet.2010.08.015
NR 39
TC 29
Z9 31
U1 2
U2 14
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0300-9084
EI 1638-6183
J9 BIOCHIMIE
JI Biochimie
PD MAY
PY 2016
VL 124
BP 65
EP 73
DI 10.1016/j.biochi.2015.08.001
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DK4UZ
UT WOS:000374917100008
PM 26248309
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sattari, M
   Karimpour, A
   Taheri, MA
   Larijani, B
   Meshkani, R
   Tabatabaei-Malazy, O
   Panahi, G
AF Sattari, Mahboobe
   Karimpour, Amin
   Taheri, Maryam Akhavan
   Larijani, Bagher
   Meshkani, Reza
   Tabatabaei-Malazy, Ozra
   Panahi, Ghodratollah
TI Optimized Effects of Fisetin and Hydroxychloroquine on ER Stress and
   Autophagy in Nonalcoholic Fatty Pancreas Disease in Mice
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Article
DE autophagy; ER stress; fatty pancreas; fisetin; hydroxychloroquine;
   metabolic syndrome
ID INSULIN-RESISTANCE; HEPATIC STEATOSIS; ECTOPIC FAT; BETA-CELL; IN-VIVO;
   DIET; CHLOROQUINE; INJURY; DRUG
AB Background: Fat accumulation in the pancreas, known as nonalcoholic fatty pancreatic disease (NAFPD), is associated with obesity and may lead to prediabetes and Type 2 diabetes. Reducing endoplasmic reticulum stress and enhancing autophagy could offer therapeutic benefits. This study examines the effects of fisetin (FSN) and hydroxychloroquine (HCQ) on NAFPD.Method: Forty-eight Male C57BL/6 J mice were assigned to a standard chow diet (SCD) or a high-fat diet (HFD) for 16 weeks. The HFD group was divided into five subgroups; each group contains eight mice: HFD, HFD + V (vehicle), HFD + FSN, HFD + HCQ, and HFD + FSN + HCQ. FSN was given daily at 80 mg/kg, and HCQ was injected IP at 50 mg/kg twice weekly for more 8 weeks. Insulin resistance was assessed through OGTT and HOMA-IR. Histological analysis of pancreatic tissue was conducted, and the protein and mRNA levels of molecules associated with ER stress and autophagy were assessed using PCR and immunoblotting techniques.Result: FSN and HCQ significantly reduced weight gain, pancreatic adipocyte accumulation, and insulin resistance caused by HFD in obese mice, with the combination of the two compounds producing even more pronounced effects. Additionally, the HFD increased the expression of UPR markers ATF4 and CHOP, a response that was further intensified by HCQ. In contrast, FSN attenuated the UPR by regulating GRP78 levels. Furthermore, the HFD resulted in a significant decrease in the LC3II/LC3I ratio and an accumulation of p62 protein due to reduced p-AMPK levels. Following treatment with FSN, these alterations were reversed, leading to decreased mTOR expression and increased levels of autophagy markers such as ATG5 and Beclin1.Conclusion: Our study reveals that FSN and HCQ effectively combat HFD-induced NAFPD, improving insulin sensitivity and addressing pancreatic fat deposition linked to metabolic syndrome. While HCQ may cause endoplasmic reticulum stress, FSN offers protective effects, supporting their combined use for better treatment outcomes.
C1 [Sattari, Mahboobe; Larijani, Bagher] Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Endocrinol & Metab Res Ctr, Tehran, Iran.
   [Sattari, Mahboobe; Karimpour, Amin; Meshkani, Reza; Panahi, Ghodratollah] Univ Tehran Med Sci, Fac Med, Dept Clin Biochem, Tehran, Iran.
   [Karimpour, Amin] Univ Tehran Med Sci, Students Sci Res Ctr SSRC, Tehran, Iran.
   [Taheri, Maryam Akhavan] Kashan Univ Med Sci, Inst Basic Sci, Anat Sci Res Ctr, Kashan, Iran.
   [Tabatabaei-Malazy, Ozra] Univ Tehran Med Sci, Endocrinol & Metab Populat Sci Inst, Noncommunicable Dis Res Ctr, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences; Tehran University of
   Medical Sciences
RP Panahi, G (corresponding author), Univ Tehran Med Sci, Fac Med, Dept Clin Biochem, Tehran, Iran.; Tabatabaei-Malazy, O (corresponding author), Univ Tehran Med Sci, Endocrinol & Metab Populat Sci Inst, Noncommunicable Dis Res Ctr, Tehran, Iran.
EM tabatabaeiml@sina.tums.ac.ir; pshahriyar@gmail.com
RI Tabatabaei-Malazy, ozra/T-5561-2017; panahi, shahriyar/W-3772-2019;
   larijani, Bagher/ABE-3315-2020; Tabatabaei, ozra/E-3634-2013
OI Tabatabaei, ozra/0000-0003-0188-9721; Larijani,
   Bagher/0000-0001-5386-7597
FU Tehran University of Medical Sciences and Health Services
FX We express our gratitude to Tehrandarou Co. for supplying the
   hydroxychloroquine. We appreciate the Department of Clinical
   Biochemistry of Tehran University of Medical Science's staff and our
   colleagues for their invaluable assistance in conducting this study and
   for providing the best conditions, especially for the mice used in this
   research. We would like to acknowledge the assistance of an AI writing
   assistant in improving the quality of this manuscript.
CR Abdel-Hamid AAM, 2016, ACTA HISTOCHEM, V118, P560, DOI 10.1016/j.acthis.2016.06.002
   Akin AT, 2022, CLIN EXP PHARMACOL P, V49, P813, DOI 10.1111/1440-1681.13669
   Alam MM, 2016, APOPTOSIS, V21, P1191, DOI 10.1007/s10495-016-1277-7
   Ballester-Vallés C, 2020, RADIOLOGIA-MADRID, V62, P122, DOI 10.1016/j.rx.2019.05.010
   Benedé-Ubieto R, 2020, DIABET METAB SYND OB, V13, P439, DOI 10.2147/DMSO.S234665
   Carvalho Alzira Alves de Siqueira, 2020, Curr Pharmacol Rep, V6, P364, DOI 10.1007/s40495-020-00243-4
   Choi MS, 2020, J MED FOOD, V23, P1019, DOI 10.1089/jmf.2019.4619
   Chu KY, 2015, DIABETOLOGIA, V58, P2074, DOI 10.1007/s00125-015-3665-x
   Coe PO, 2018, PANCREATOLOGY, V18, P429, DOI 10.1016/j.pan.2018.04.001
   Dai XL, 2022, J FUNCT FOODS, V90, DOI 10.1016/j.jff.2022.104954
   Ding HG, 2022, CNS NEUROSCI THER, V28, P247, DOI 10.1111/cns.13765
   Dite P, 2020, DIGEST DIS, V38, P143, DOI 10.1159/000505366
   Dludla PV, 2023, WORLD J DIABETES, V14, DOI 10.4239/wjd.v14.i3.130
   Elhady M, 2019, J PEDIATR ENDOCR MET, V32, P19, DOI 10.1515/jpem-2018-0315
   Fang TY, 2021, EXP CLIN ENDOCR DIAB, V129, P625, DOI 10.1055/a-1240-4936
   Filippatos TD, 2022, DIGEST DIS SCI, V67, P26, DOI 10.1007/s10620-021-06824-7
   Ge CX, 2019, FREE RADICAL BIO MED, V141, P67, DOI 10.1016/j.freeradbiomed.2019.05.031
   Ghemrawi R, 2018, CELLS-BASEL, V7, DOI 10.3390/cells7060063
   Gressier F, 2020, J CLIN PSYCHIAT, V81, DOI 10.4088/JCP.20l13476
   Grynkiewicz G, 2019, FRONT CHEM, V7, DOI 10.3389/fchem.2019.00697
   Hao T, 2017, INT J MOL MED, V39, P1029, DOI 10.3892/ijmm.2017.2910
   Jiang Y., 2019, Nutrients, V11
   Khin PP, 2023, EUR J INFLAMM, V21, DOI 10.1177/1721727X231154152
   Kielkopf Clara L, 2020, Cold Spring Harb Protoc, V2020, P102269, DOI 10.1101/pdb.prot102269
   Lee JH, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23094843
   Lesmana CRA, 2015, BMC GASTROENTEROL, V15, DOI 10.1186/s12876-015-0404-1
   Li T, 2023, NUTR METAB, V20, DOI 10.1186/s12986-023-00770-z
   Liu LM, 2016, BIOCHEM BIOPH RES CO, V470, P516, DOI 10.1016/j.bbrc.2016.01.116
   Majumder S, 2017, PANCREAS, V46, P1251, DOI 10.1097/MPA.0000000000000941
   Masui Y, 2019, J ENDOCRINOL METAB, V9, P159, DOI 10.14740/jem611
   Matheus VA, 2017, EXP BIOL MED, V242, P1214, DOI 10.1177/1535370217708188
   Mauthe M, 2018, AUTOPHAGY, V14, P1435, DOI 10.1080/15548627.2018.1474314
   Mihanfar A, 2021, J STEROID BIOCHEM, V213, DOI 10.1016/j.jsbmb.2021.105954
   Moulis M, 2017, CELLS-BASEL, V6, DOI 10.3390/cells6020014
   Neeland IJ, 2019, LANCET DIABETES ENDO, V7, P715, DOI 10.1016/S2213-8587(19)30084-1
   Pinnick KE, 2008, OBESITY, V16, P522, DOI 10.1038/oby.2007.110
   Poitout V, 2010, BBA-MOL CELL BIOL L, V1801, P289, DOI 10.1016/j.bbalip.2009.08.006
   Qiao X, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.00855
   Rigoli L, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19063225
   Rouse R, 2014, TOXICOL APPL PHARM, V276, P104, DOI 10.1016/j.taap.2014.01.021
   Sahin E, 2022, LIFE SCI, V306, DOI 10.1016/j.lfs.2022.120781
   Sattari M, 2024, J DIABETES METAB DIS, V23, P1753, DOI 10.1007/s40200-024-01502-7
   Shen J, 2022, PLANT FOOD HUM NUTR, V77, P12, DOI 10.1007/s11130-021-00946-z
   Sheng R, 2019, ADV EXP MED BIOL, V1206, P3, DOI 10.1007/978-981-15-0602-4_1
   Singh RG, 2017, METABOLISM, V69, P1, DOI 10.1016/j.metabol.2016.12.012
   Song SL, 2018, J CELL PHYSIOL, V233, P3867, DOI 10.1002/jcp.26137
   Takahashi M, 2018, CANCER SCI, V109, P3013, DOI 10.1111/cas.13766
   Toledo FGS, 2021, DIABETES OBES METAB, V23, P1252, DOI 10.1111/dom.14333
   Undamatla R, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-34710-x
   Wasko MCM, 2015, DIABETOLOGIA, V58, P2336, DOI 10.1007/s00125-015-3689-2
   Wong SK, 2021, INT J MED SCI, V18, P2673, DOI 10.7150/ijms.58147
   Wu FZ, 2018, J NEUROTRAUM, V35, P1329, DOI 10.1089/neu.2017.5414
   Xu MX, 2019, J FUNCT FOODS, V53, P7, DOI 10.1016/j.jff.2018.12.007
   Xu MX, 2019, FOOD FUNCT, V10, P1302, DOI 10.1039/c8fo01615a
   Yong J, 2021, NAT REV ENDOCRINOL, V17, P455, DOI 10.1038/s41574-021-00510-4
   Zhang JQ, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00162
NR 56
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PY 2025
VL 2025
IS 1
AR 2795127
DI 10.1155/jdr/2795127
PG 15
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA 1IQ0A
UT WOS:001465912300001
PM 40260275
OA gold
DA 2025-06-11
ER

PT J
AU Kanagasabai, T
   Alkhalaqi, K
   Churilla, JR
   Ardern, CI
AF Kanagasabai, Thirumagal
   Alkhalaqi, Khloud
   Churilla, James R.
   Ardern, Chris I.
TI The Association Between Metabolic Syndrome and Serum Concentrations of
   Micronutrients, Inflammation, and Oxidative Stress Outside of the
   Clinical Reference Ranges: A Cross-Sectional Study
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE micronutrients; inflammation; oxidative stress; serum biomarkers;
   carotenoids; vitamins
ID GAMMA-GLUTAMYL-TRANSFERASE; IRON-DEFICIENCY; ANTIOXIDANT STATUS;
   SEX-DIFFERENCES; US ADULTS; OBESITY; PREVALENCE; IMPACT; RISK
AB Background: Clinical reference ranges are often used to assess nutritional status, but whether having lower or higher than the current clinical reference range for micronutrients, inflammation, and oxidative stress is related to metabolic syndrome (MetS) is not known. Our objectives are to estimate the odds of having MetS outside of established clinical references, and to identify any effect modifications by sex for these relationships. Methods: Data from the 2005 to 2006 National Health and Nutrition Examination Survey were used (20 years; N=2049) with MetS defined utilizing the harmonized criteria from the Joint Interim Statement. The odds of having MetS in individuals with lower or higher than the clinical reference range for the serum concentrations of micronutrient antioxidants, inflammation, and oxidative stress were estimated following adjustments for age, sex, ethnicity, education, income, smoking, alcohol intake, recreational physical activity, and BMI. Results: Having lower than the clinical reference range for carotenoids and vitamin C [odds ratios (95% confidence interval): 1.37 (1.05-1.78) and 1.39 (1.01-1.90), respectively] was associated with significantly greater odds of MetS. By contrast, having higher than the clinical reference range for vitamins A and E, uric acid, and -glutamyl transferase (GGT) [2.10 (1.50-2.92), 2.36 (1.78-3.13), 2.65 (1.54-4.57), and 2.08 (1.61-2.69), respectively] was associated with higher odds of MetS, whereas higher levels of vitamins B12 were protective [0.64 (0.42-0.98]. Sex moderated these relationships for carotenoids, vitamin A, C, E, uric acid, C-reactive protein, and GGT. Conclusions: Lower carotenoids and vitamin C and higher vitamins A and E, uric acid, and oxidative stress were associated with a greater likelihood of MetS, whereas higher vitamin B12 was protective. Further research is necessary to replicate these findings in a prospective setting to confirm the importance of the overall and sex-specific findings.
C1 [Kanagasabai, Thirumagal; Ardern, Chris I.] York Univ, Sch Kinesiol & Hlth Sci, Toronto, ON, Canada.
   [Alkhalaqi, Khloud] MiSK Sch, Acad Dept, Riyadh, Saudi Arabia.
   [Churilla, James R.] Univ North Florida, Brooks Coll Hlth, Jacksonville, FL USA.
   [Kanagasabai, Thirumagal] McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, 1130 Ave Pins, Montreal, PQ H3G 1A1, Canada.
C3 York University - Canada; State University System of Florida; University
   of North Florida; McGill University
RP Kanagasabai, T (corresponding author), McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, 1130 Ave Pins, Montreal, PQ H3G 1A1, Canada.
EM tkanagas@yorku.ca
RI Churilla, James/AIB-2665-2022
CR Abete I, 2011, NUTR METAB CARDIOVAS, V21, pB1, DOI 10.1016/j.numecd.2011.05.001
   Aggoun Y, 2007, PEDIATR RES, V61, P653, DOI [10.1203/pdr.0b013e31805d8a8c, 10.1210/jc.2004-0372]
   Al-Daghri NM, 2013, NUTRIENTS, V5, P4587, DOI 10.3390/nu5114587
   American Medical Association, AMA REF RANG
   [Anonymous], 2018, GLOB DAT BOD MASS IN
   [Anonymous], J METAB SYND
   Asarian L, 2013, AM J PHYSIOL-REG I, V305, pR1215, DOI 10.1152/ajpregu.00446.2012
   Balamurugan R, 2010, BRIT J NUTR, V104, P931, DOI 10.1017/S0007114510001637
   Beydoun MA, 2011, J NUTR, V141, P903, DOI 10.3945/jn.110.136580
   Bian SS, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-106
   Bo S, 2005, WORLD J GASTROENTERO, V11, P7109, DOI 10.3748/wjg.v11.i45.7109
   Bray GA, 2006, ENDOCRINE, V29, P109, DOI 10.1385/ENDO:29:1:109
   Cairo G, 2006, GENES NUTR, V1, P25, DOI 10.1007/BF02829934
   Center for Nutrition Policy and Promotion, DIET GUID AM
   Continuous NHANES Web Tutorial, CONTINUOUS NHANES WE
   Datz C, 2013, EUR J CLIN INVEST, V43, P215, DOI 10.1111/eci.12032
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   García OP, 2009, NUTR REV, V67, P559, DOI 10.1111/j.1753-4887.2009.00228.x
   Geer EB, 2009, GENDER MED, V6, P60, DOI 10.1016/j.genm.2009.02.002
   Giral P, 2010, ATHEROSCLEROSIS, V210, P607, DOI 10.1016/j.atherosclerosis.2009.12.026
   Goncalves A, 2017, CURR OPIN CLIN NUTR, V20, P492, DOI 10.1097/MCO.0000000000000412
   Grundy SM, 2012, J AM COLL CARDIOL, V59, P635, DOI 10.1016/j.jacc.2011.08.080
   Hopps E, 2010, NUTR METAB CARDIOVAS, V20, P72, DOI 10.1016/j.numecd.2009.06.002
   Kamper EF, 2009, PHYSIOL BEHAV, V98, P215, DOI 10.1016/j.physbeh.2009.05.011
   Kanagasabai T, 2015, SLEEP, V38, P1905, DOI 10.5665/sleep.5238
   Kanagasabai T, 2015, INT J BEHAV NUTR PHY, V12, DOI 10.1186/s12966-015-0227-z
   Katzmarzyk PT, 2005, DIABETES CARE, V28, P391, DOI 10.2337/diacare.28.2.391
   Kimmons Joel E, 2006, MedGenMed, V8, P59
   Lee Ju-Mi, 2012, J Prev Med Public Health, V45, P181, DOI 10.3961/jpmph.2012.45.3.181
   Li YR, 2013, ASIA PAC J CLIN NUTR, V22, P60, DOI 10.6133/apjcn.2013.22.1.06
   McClung JP, 2009, NUTR REV, V67, P100, DOI 10.1111/j.1753-4887.2008.00145.x
   Motamed Soudabe, 2013, N Am J Med Sci, V5, P377, DOI 10.4103/1947-2714.114171
   Mozumdar A, 2011, DIABETES CARE, V34, P216, DOI 10.2337/dc10-0879
   Nakagawa T, 2005, NAT CLIN PRACT NEPHR, V1, P80, DOI 10.1038/ncpneph0019
   Nakagawa T, 2006, AM J PHYSIOL-RENAL, V290, pF625, DOI 10.1152/ajprenal.00140.2005
   National Center for Health Statistics, 2017, NATL HLTH NUTR EXAMI
   NCHS, NHANES NHANES 2005 2
   Office of Disease Prevention and Health Promotion, 2008, PHYS ACT GUID AM
   Onat A, 2012, OBESITY, V20, P842, DOI 10.1038/oby.2011.136
   Ramakrishna BS, J GASTROENTEROL HEPA, V28, P9
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Russo A, 2008, EUR J CANCER, V44, P293, DOI 10.1016/j.ejca.2007.11.005
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Yanoff LB, 2007, INT J OBESITY, V31, P1412, DOI 10.1038/sj.ijo.0803625
NR 45
TC 19
Z9 19
U1 0
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD FEB 1
PY 2019
VL 17
IS 1
BP 29
EP 36
DI 10.1089/met.2018.0080
EA OCT 2018
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HR8IS
UT WOS:000448561600001
PM 30372368
DA 2025-06-11
ER

PT J
AU Khan, MR
   Sheehan, PK
   Bazin, A
   Leonard, C
   Aleem, U
   Corrigan, L
   McDermott, R
AF Khan, M. Raheel
   Sheehan, Patrice Kearney
   Bazin, Ashley
   Leonard, Christine
   Aleem, Umair
   Corrigan, Lynda
   McDermott, Ray
TI Late side effects of testicular cancer and treatment: a comprehensive
   review
SO DISCOVER ONCOLOGY
LA English
DT Review
DE Testicular cancer; Cancer survivorship; Germ cell tumours; Chemotherapy
   late side-effect
ID GERM-CELL TUMORS; LYMPH-NODE DISSECTION; LONG-TERM SURVIVORS;
   CISPLATIN-BASED CHEMOTHERAPY; COLONY-STIMULATING FACTOR; RISK-FACTORS;
   PULMONARY-FUNCTION; COMBINATION CHEMOTHERAPY; CARDIOVASCULAR-DISEASE;
   ADJUVANT CHEMOTHERAPY
AB Testicular cancer is a rare solid organ tumour associated with high cure rates and young age at diagnosis, hence it has a sizeable cohort of survivors worldwide. As it is one of the earliest tumours to be cured, a lot of studies have highlighted the late side effects of cancer and its different treatment modalities including surgery, radiotherapy and chemotherapy. While we are trying to identify the population at higher risk of platinum based chemotherapy and reduce its exposure, cisplatin based regimes remain an important tool to cure testicular cancer. The list of late side effects include a number of fatal and morbid conditions including but not limited to the second malignant neoplasms, cardiovascular disease, hypogonadism, infertility, metabolic syndrome, chronic respiratory disease, renal insufficiency, hearing loss, peripheral neuropathy, infertility and psychological illnesses like stress and anxiety. These complications eventually result in compromised social and economic health as well as lower life expectancy compared to the normal population. This article provides a comprehensive review of the latest data regarding the late side effects in testicular cancer survivors. A review of these conditions can help us develop recommendations and guidelines to improve the morbidity and mortality in survivors of testicular cancer.
C1 [Khan, M. Raheel; Sheehan, Patrice Kearney; Bazin, Ashley; Leonard, Christine; Corrigan, Lynda; McDermott, Ray] Tallaght Univ Hosp, Dept Med Oncol, Tallaght, Dublin, Ireland.
   [McDermott, Ray] Univ Coll Dublin, Sch Med, Belfield D04 V1W8, Dublin, Ireland.
   [McDermott, Ray] St Vincents Univ Hosp, Dept Med Oncol, Elm Pk D04 YN26, Dublin, Ireland.
   [Aleem, Umair] Christie NHS Fdn Trust, Dept Med Oncol, 550 Wilmslow Rd, Manchester M20 4BX, England.
C3 University College Dublin; University College Dublin; Saint Vincent's
   University Hospital; Christie NHS Foundation Trust
RP Khan, MR (corresponding author), Tallaght Univ Hosp, Dept Med Oncol, Tallaght, Dublin, Ireland.
EM mraheelhashim@hotmail.com
RI McDermott, Sean/KYR-3316-2024
OI Khan, M Raheel/0009-0004-2828-5826
CR Adachi K, 2002, EXP TOXICOL PATHOL, V53, P501, DOI 10.1078/0940-2993-00218
   Agrawal V, 2020, JNCI CANCER SPECT, V4, DOI 10.1093/jncics/pkz079
   Albers P, 2008, J CLIN ONCOL, V26, P2966, DOI 10.1200/JCO.2007.12.0899
   Aparicio J, 2005, J CLIN ONCOL, V23, P8717, DOI 10.1200/JCO.2005.01.9810
   Aydiner A, 1997, ONCOLOGY, V54, P74
   Berger LA, 2014, J CANCER RES CLIN, V140, P1211, DOI 10.1007/s00432-014-1661-z
   Beyer J, 2010, J CLIN ONCOL, V28, P4906, DOI 10.1200/JCO.2009.26.8128
   Bjerner J, 2009, SCAND J CLIN LAB INV, V69, P873, DOI 10.3109/00365510903380886
   Bjerring AW, 2021, EUR HEART J-CARD IMG, V22, P443, DOI 10.1093/ehjci/jeaa289
   Blok JM, 2020, BJU INT, V125, P355, DOI 10.1111/bju.14967
   Bogefors C, 2017, ANDROLOGY-US, V5, P711, DOI 10.1111/andr.12354
   Brydoy M, 2009, J NATL CANCER I, V101, P1682, DOI 10.1093/jnci/djp413
   Busch J, 2022, WORLD J UROL, V40, P2843, DOI 10.1007/s00345-022-03931-6
   Chevreau C, 2004, EUR UROL, V46, P209, DOI 10.1016/j.eururo.2004.03.022
   Classen J, 2003, J CLIN ONCOL, V21, P1101, DOI 10.1200/JCO.2003.06.065
   Cullen MH, 1996, J CLIN ONCOL, V14, P1106, DOI 10.1200/JCO.1996.14.4.1106
   Daugaard G, 2014, J CLIN ONCOL, V32, P3817, DOI 10.1200/JCO.2013.53.5831
   de Haas EC, 2013, ANN ONCOL, V24, P749, DOI 10.1093/annonc/mds527
   de Wit R, 2001, J CLIN ONCOL, V19, P1629, DOI 10.1200/JCO.2001.19.6.1629
   de Wit R, 1998, BRIT J CANCER, V78, P828, DOI 10.1038/bjc.1998.587
   deWit R, 1997, J CLIN ONCOL, V15, P1837, DOI 10.1200/JCO.1997.15.5.1837
   Dieckmann KP, 2017, EUR UROL, V71, P213, DOI 10.1016/j.eururo.2016.07.029
   Dobrowolski Piotr, 2022, Arch Med Sci, V18, P1133, DOI 10.5114/aoms/152921
   Doyle DM, 2008, INT J RADIAT ONCOL, V70, P1361, DOI 10.1016/j.ijrobp.2007.11.005
   Eberhard J, 2008, EUR J ENDOCRINOL, V158, P561, DOI 10.1530/EJE-07-0684
   EINHORN LH, 1977, ANN INTERN MED, V87, P293, DOI 10.7326/0003-4819-87-3-293
   EINHORN LH, 1989, J CLIN ONCOL, V7, P387, DOI 10.1200/JCO.1989.7.3.387
   Fizazi K, 2014, ANN ONCOL, V25, P987, DOI 10.1093/annonc/mdu099
   Fizazi K, 2014, LANCET ONCOL, V15, P1442, DOI 10.1016/S1470-2045(14)70490-5
   Fizazi K, 2014, EUR UROL, V65, P381, DOI 10.1016/j.eururo.2013.09.004
   Foss SD., 2017, European Urology, V10, P173, DOI 10.1159/000463782
   Fosså SD, 2004, ACTA ONCOL, V43, P134, DOI 10.1080/02841860310023174
   Fosså SD, 2007, JNCI-J NATL CANCER I, V99, P533, DOI 10.1093/jnci/djk111
   Fung C, 2022, ACTA ONCOL, V61, P386, DOI 10.1080/0284186X.2021.2024880
   Fung C, 2019, J NATL COMPR CANC NE, V17, P1557, DOI 10.6004/jnccn.2019.7369
   Garcia-del-Muro X, 2008, J CLIN ONCOL, V26, P5416, DOI 10.1200/JCO.2007.15.9103
   Giannatempo P, 2015, ANN ONCOL, V26, P657, DOI 10.1093/annonc/mdu447
   Gillessen S, 2021, J CLIN ONCOL, V39, P1563, DOI 10.1200/JCO.20.03296
   Gilligan T, 2019, J NATL COMPR CANC NE, V17, P1529, DOI 10.6004/jnccn.2019.0058
   Glendenning JL, 2010, CANCER-AM CANCER SOC, V116, P2322, DOI 10.1002/cncr.24981
   Groot HJ, 2018, J CLIN ONCOL, V36, P2504, DOI 10.1200/JCO.2017.77.4174
   Gunnes MW, 2017, INT J CANCER, V140, P575, DOI 10.1002/ijc.30474
   Hartmann JT, 1999, INT J CANCER, V83, P866, DOI 10.1002/(SICI)1097-0215(19991210)83:6<866::AID-IJC34>3.0.CO;2-9
   Haugnes HS, 2009, J CLIN ONCOL, V27, P2779, DOI 10.1200/JCO.2008.18.5181
   HAY J, 1991, ARCH TOXICOL, V65, P81, DOI 10.1007/BF02034932
   Hellesnes R, 2021, J CLIN ONCOL, V39, P3561, DOI 10.1200/JCO.21.00637
   Hinton S, 2003, CANCER-AM CANCER SOC, V97, P1869, DOI 10.1002/cncr.11271
   Honecker F, 2018, ANN ONCOL, V29, P1658, DOI 10.1093/annonc/mdy217
   Howard R, 2008, ANN EPIDEMIOL, V18, P416, DOI 10.1016/j.annepidem.2008.01.003
   Hu B, 2015, CLIN GENITOURIN CANC, V13, pE265, DOI 10.1016/j.clgc.2015.01.002
   Huang JJ, 2022, EUR UROL ONCOL, V5, P566, DOI 10.1016/j.euo.2022.06.009
   Huddart RA, 2005, BRIT J CANCER, V93, P200, DOI 10.1038/sj.bjc.6602677
   Inai H, 2013, INT J UROL, V20, P716, DOI 10.1111/iju.12017
   Joffe JK, 2022, J CLIN ONCOL, V40, P2468, DOI 10.1200/JCO.21.01199
   JULESELYSEE K, 1990, CLIN CHEST MED, V11, P1
   Kerns SL, 2020, JNCI CANCER SPECT, V4, DOI 10.1093/jncics/pkaa022
   Kerns SL, 2018, J CLIN ONCOL, V36, P1505, DOI 10.1200/JCO.2017.77.0735
   Kier MG, 2017, EUR UROL, V71, P290, DOI 10.1016/j.eururo.2016.09.015
   Kollmannsberger C, 2015, J CLIN ONCOL, V33, P51, DOI 10.1200/JCO.2014.56.2116
   Kreiberg M, 2020, J CANCER SURVIV, V14, P72, DOI 10.1007/s11764-019-00835-0
   Kvammen O, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0225942
   Kvammen O, 2016, CANCER EPIDEM BIOMAR, V25, P773, DOI 10.1158/1055-9965.EPI-15-1153
   Kwan EM, 2018, CLIN GENITOURIN CANC, V16, pE193, DOI 10.1016/j.clgc.2017.08.012
   Lauritsen J, 2020, J CLIN ONCOL, V38, P584, DOI 10.1200/JCO.19.01180
   Lauritsen J, 2016, J CLIN ONCOL, V34, P1492, DOI 10.1200/JCO.2015.64.8451
   Lubberts S, 2023, J CLIN ONCOL, V41, P3512, DOI 10.1200/JCO.22.01016
   Mai PL, 2009, FAM CANCER, V8, P451, DOI 10.1007/s10689-009-9264-6
   Maruyama Y, 2018, MED ONCOL, V35, DOI 10.1007/s12032-018-1140-5
   McHugh DJ, 2018, ADV UROL, V2018, DOI 10.1155/2018/7272541
   Mead GM, 2005, BRIT J CANCER, V93, P178, DOI 10.1038/sj.bjc.6602682
   Motzer RJ, 2007, J CLIN ONCOL, V25, P247, DOI 10.1200/JCO.2005.05.4528
   Neuenschwander A, 2023, EUR UROL FOCUS, V9, P541, DOI 10.1016/j.euf.2022.11.003
   Nezu K, 2022, INT J UROL, V29, P1526, DOI 10.1111/iju.15039
   NICHOLS CR, 1993, J NATL CANCER I, V85, P36, DOI 10.1093/jnci/85.1.36
   Nome RV, 2021, ACTA ONCOL, V60, P1452, DOI 10.1080/0284186X.2021.1958004
   Nuver J, 2005, J CLIN ONCOL, V23, P9130, DOI 10.1200/JCO.2005.01.4092
   Nuver J, 2004, EUR J CANCER, V40, P701, DOI 10.1016/j.ejca.2003.12.012
   Nuver J, 2010, ONCOL REP, V23, P247, DOI 10.3892/or_00000630
   Oh JH, 2007, MED ONCOL, V24, P175, DOI 10.1007/BF02698037
   Oing C, 2016, EXPERT OPIN INV DRUG, V25, P1033, DOI 10.1080/13543784.2016.1195808
   Oldenburg J, 2007, J TRANSL MED, V5, DOI 10.1186/1479-5876-5-70
   Oliver RTD, 2011, J CLIN ONCOL, V29, P957, DOI 10.1200/JCO.2009.26.4655
   Ondrus D, 2014, INT UROL NEPHROL, V46, P749, DOI 10.1007/s11255-013-0554-4
   Ondrusova M, 2018, AM J MENS HEALTH, V12, P628, DOI 10.1177/1557988316661986
   Park JS, 2018, MEDICINE, V97, DOI [10.1097/MD.0000000000012390, 10.1097/md.0000000000012390]
   Patel HD, 2017, UROL ONCOL-SEMIN ORI, V35, DOI 10.1016/j.urolonc.2017.06.051
   Petersen PM, 1999, J UROLOGY, V161, P822, DOI 10.1016/S0022-5347(01)61781-6
   Pettus JA, 2009, UROLOGY, V73, P328, DOI 10.1016/j.urology.2008.08.501
   Pont J, 1996, J CLIN ONCOL, V14, P441, DOI 10.1200/JCO.1996.14.2.441
   Pühse G, 2010, INT J ANDROL, V33, pE216, DOI 10.1111/j.1365-2605.2009.00994.x
   Raghavan Derek, 2003, Oncology (Williston Park), V17, P218
   Raj S, 2008, FUTURE ONCOL, V4, P1, DOI 10.2217/14796694.4.1.1
   Raphael MJ, 2021, J CLIN ONCOL, V39, P779, DOI 10.1200/JCO.20.02298
   Rey RA, 2013, ANDROLOGY-US, V1, P3, DOI 10.1111/j.2047-2927.2012.00008.x
   Roncolato FT, 2016, INTERN MED J, V46, P893, DOI 10.1111/imj.13158
   Schepisi G, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00113
   Selvi I, 2020, SUPPORT CARE CANCER, V28, P4313, DOI 10.1007/s00520-019-05266-2
   Seretny M, 2014, PAIN, V155, P2461, DOI 10.1016/j.pain.2014.09.020
   Sigg S, 2023, CURR OPIN UROL, V33, P245, DOI 10.1097/MOU.0000000000001099
   Smith A, 2018, PSYCHO-ONCOLOGY, V27, P1129, DOI 10.1002/pon.4596
   Sohaib SA, 2009, CLIN RADIOL, V64, P362, DOI 10.1016/j.crad.2008.10.011
   Soni KK, 2016, DRUG DES DEV THER, V10, P3959, DOI 10.2147/DDDT.S120014
   SPEARS WT, 1992, INT J RADIAT ONCOL, V22, P17, DOI 10.1016/0360-3016(92)90977-P
   Sprauten M, 2014, J CLIN ONCOL, V32, P571, DOI 10.1200/JCO.2013.51.2715
   Sprauten M, 2012, J CLIN ONCOL, V30, P300, DOI 10.1200/JCO.2011.37.4025
   Thorsen L, 2005, SUPPORT CARE CANCER, V13, P637, DOI 10.1007/s00520-004-0769-0
   Travis LB, 2005, JNCI-J NATL CANCER I, V97, P1354, DOI 10.1093/jnci/dji278
   Travis LB, 2000, JNCI-J NATL CANCER I, V92, P1165, DOI 10.1093/jnci/92.14.1165
   van den Belt-Dusebout AW, 2007, J CLIN ONCOL, V25, P4370, DOI 10.1200/JCO.2006.10.5296
   van der Schoot GGF, 2016, EUR J CANCER, V59, P134, DOI 10.1016/j.ejca.2016.02.013
   Vaughn DJ, 2008, CANCER-AM CANCER SOC, V112, P1949, DOI 10.1002/cncr.23389
   Walsh JS, 2019, PLOS MED, V16, DOI 10.1371/journal.pmed.1002960
   Wibmer AG, 2022, JNCI CANCER SPECT, V6, DOI 10.1093/jncics/pkac030
   Zaorsky NG, 2019, NAT COMMUN, V10, DOI [10.1038/s41467-018-08170-1, 10.1038/s41467-019-13120-6]
NR 114
TC 0
Z9 0
U1 2
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
EI 2730-6011
J9 DISCOV ONCOL
JI Discov. Oncol.
PD NOV 12
PY 2024
VL 15
IS 1
AR 646
DI 10.1007/s12672-024-01549-1
PG 13
WC Oncology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Endocrinology & Metabolism
GA L8C1V
UT WOS:001352938700002
PM 39532799
OA Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Kim, OY
   Paik, JK
   Lee, JY
   Lee, SH
   Lee, JH
AF Kim, Oh Yoen
   Paik, Jean Kyung
   Lee, Ju Young
   Lee, Sang-Hyun
   Lee, Jong Ho
TI Follow-Ups of Metabolic, Inflammatory and Oxidative Stress Markers, and
   Brachial-Ankle Pulse Wave Velocity in Middle-Aged Subjects without
   Metabolic Syndrome
SO CLINICAL AND EXPERIMENTAL HYPERTENSION
LA English
DT Article
DE MetS; inflammatory; oxidative stress markers; brachial-ankle pulse wave
   velocity
ID BLOOD-CELL COUNT; CARDIOVASCULAR-DISEASE ENTERPRISES; ARTERIAL
   STIFFNESS; MAJOR SHAREHOLDERS; RISK-FACTORS; INTERLEUKIN-6;
   HYPERTENSION; CORONARY; DENSITY; EVENTS
AB This study investigates the association among metabolic risk factors, inflammatory and oxidative stress markers, and brachial-ankle pulse wave velocity (ba-PWV). We conducted a 3-year longitudinal, observational study of 288 middle-aged adults not meeting the criteria for metabolic syndrome (MetS) at the initial screening. We measured metabolic risk factors, inflammatory and oxidative stress markers, and ba-PWV. Within the 3-year study period, 15.6% (45 out of 288) of participants developed MetS. At the 3-year follow-up, patients were categorized as those with MetS (n = 45) and those without MetS (n = 243). Patients with MetS had significantly unfavorable initial measurements of baseline body mass index (BMI), waist circumference (WC), blood pressure (BP), triglyceride (TG), high-density lipoprotein (HDL)-cholesterol, glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR) index, and ba-PWV. After 3 years, participants without MetS showed significant increases in WC, diastolic BP (DBP), total-and low-density lipoprotein (LDL)-cholesterol, malondialdehyde (MDA), oxidized-LDL (ox-LDL), and ba-PWV and a significant decrease in HDL-cholesterol and free fatty acids (FFA). Subjects who developed MetS showed significant increases in BMI, WC, BP, TG, glucose, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), MDA, ox-LDL, and ba-PWV and a significant decrease in HDL-cholesterol. Changes in BMI, WC, BP, TG, HDL-cholesterol, glucose, HOMA-IR index, FFA, C-reactive protein (P = .022), IL-6 (P = .004), leukocyte count (P < .001), MDA (P = .002), ox-LDL (P = .015), and ba-PWV (P = .001) differed significantly between the two groups after adjustment for baseline values. Changes in ba-PWV were positively correlated with the changes in systolic and DBP, total-cholesterol, glucose, leukocyte count, and MDA. The age-related increase in arterial stiffness is greater in the presence of MetS with higher levels of inflammatory and oxidative stress markers.
C1 [Kim, Oh Yoen] Dong A Univ, Dept Food Sci & Nutr, Pusan, South Korea.
   [Paik, Jean Kyung] Eulji Univ, Dept Food & Nutr, Gyeonggi Do, South Korea.
   [Lee, Ju Young; Lee, Jong Ho] Yonsei Univ, Dept Food & Nutr, Natl Leading Res Lab Clin Nutrigenet Nutrigen, Seoul 120749, South Korea.
   [Lee, Sang-Hyun] Natl Hlth Insurance Corp Ilsan Hosp, Dept Family Practice, Goyang Si, South Korea.
   [Lee, Jong Ho] Yonsei Univ, Res Inst Sci Aging, Seoul 120749, South Korea.
C3 Dong A University; Eulji University; Yonsei University; Yonsei
   University
RP Lee, JH (corresponding author), Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, 134 Shinchon Dong, Seoul 120749, South Korea.
EM jhleeb@yonsei.ac.kr
RI Lee, Sang-Hyun/ABR-3363-2022; Kim, Oh/AAA-6492-2022
FU Mid-Career Researcher Program through National Research Foundation,
   Ministry of Education, Science and Technology, Republic of Korea
   [2012-0005604, M10642120002-06N4212-00210, 2012M3A9C4048762,
   2012-0001851]; National Research Foundation of Korea [2012M3A9C4048762]
   Funding Source: Korea Institute of Science & Technology Information
   (KISTI), National Science & Technology Information Service (NTIS)
FX This work was supported by the Mid-Career Researcher Program through
   National Research Foundation, Ministry of Education, Science and
   Technology (2012-0005604, M10642120002-06N4212-00210, 2012M3A9C4048762
   and 2012-0001851), Republic of Korea.
CR Barzilay JI, 2001, DIABETES, V50, P2384, DOI 10.2337/diabetes.50.10.2384
   Beltowski J, 2006, ATHEROSCLEROSIS, V189, P47, DOI 10.1016/j.atherosclerosis.2006.03.003
   Brinkley TE, 2009, HYPERTENSION, V53, P846, DOI 10.1161/HYPERTENSIONAHA.108.127043
   Dao HH, 2005, CARDIOVASC RES, V66, P307, DOI 10.1016/j.cardiores.2005.01.012
   Esmaillzadeh A, 2011, EUR J CLIN NUTR, V65, P598, DOI 10.1038/ejcn.2010.284
   Fernandez-Real JM, 2001, J CLIN ENDOCR METAB, V86, P1154, DOI 10.1210/jc.86.3.1154
   Fried SK, 1998, J CLIN ENDOCR METAB, V83, P847, DOI 10.1210/jc.83.3.847
   GRIMM RH, 1985, JAMA-J AM MED ASSOC, V254, P1932, DOI 10.1001/jama.254.14.1932
   Grundy SM, 2003, JAMA-J AM MED ASSOC, V290, P3000, DOI 10.1001/jama.290.22.3000
   Hsu PF, 2008, DIABETES RES CLIN PR, V79, P461, DOI 10.1016/j.diabres.2007.09.021
   Hung CS, 2009, NUTR METAB CARDIOVAS, V19, P241, DOI 10.1016/j.numecd.2008.07.006
   Kals J, 2008, SCAND J CLIN LAB INV, V68, P594, DOI 10.1080/00365510801930626
   Kampus P, 2006, INT J CARDIOL, V112, P46, DOI 10.1016/j.ijcard.2005.08.026
   Lakatta EG, 2003, CIRCULATION, V107, P139, DOI 10.1161/01.CIR.0000048892.83521.58
   Lakatta EG, 2003, CIRCULATION, V107, P490, DOI 10.1161/01.CIR.0000048894.99865.02
   Lao XQ, 2008, ATHEROSCLEROSIS, V201, P418, DOI 10.1016/j.atherosclerosis.2007.12.053
   Li CR, 2010, ATHEROSCLEROSIS, V209, P545, DOI 10.1016/j.atherosclerosis.2009.09.029
   Lin YC, 2009, CHRONOBIOL INT, V26, P740, DOI 10.1080/07420520902929029
   Mohamed-Ali V, 1997, J CLIN ENDOCR METAB, V82, P4196, DOI 10.1210/jc.82.12.4196
   O'Rourke MF, 2007, J AM COLL CARDIOL, V50, P1, DOI 10.1016/j.jacc.2006.12.050
   Ridker PM, 1998, CIRCULATION, V98, P731, DOI 10.1161/01.CIR.98.8.731
   Safar ME, 2006, J AM COLL CARDIOL, V47, P72, DOI 10.1016/j.jacc.2005.08.052
   Scuteri A, 2004, J AM COLL CARDIOL, V43, P1388, DOI 10.1016/j.jacc.2003.10.061
   Scuteri A, 2011, ATHEROSCLEROSIS, V215, P459, DOI 10.1016/j.atherosclerosis.2010.12.023
   Sekitani Y, 2010, BIOMARKERS, V15, P454, DOI 10.3109/1354750X.2010.486870
   Shimada K, 2004, CLIN CHIM ACTA, V344, P1, DOI 10.1016/j.cccn.2004.02.020
   Tomiyama H, 2006, HYPERTENS RES, V29, P673, DOI 10.1291/hypres.29.673
   Tomiyama H, 2010, CIRC J, V74, P24, DOI 10.1253/circj.CJ-09-0534
   Tso T, 2005, LUPUS, V14, P878, DOI 10.1191/0961203305lu2234oa
   Tsuchikura S, 2010, J ATHEROSCLER THROMB, V17, P658, DOI 10.5551/jat.3616
   Wannamethee SG, 2007, J THROMB HAEMOST, V5, P1637, DOI 10.1111/j.1538-7836.2007.02643.x
   Zieman SJ, 2005, ARTERIOSCL THROM VAS, V25, P932, DOI 10.1161/01.ATV.0000160548.78317.29
NR 32
TC 13
Z9 13
U1 0
U2 1
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1064-1963
EI 1525-6006
J9 CLIN EXP HYPERTENS
JI Clin. Exp. Hypertens.
PY 2013
VL 35
IS 5
BP 382
EP 388
DI 10.3109/10641963.2012.739232
PG 7
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA 180FM
UT WOS:000321579000012
PM 23148723
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Das, UN
AF Das, UN
TI Perinatal supplementation of long-chain polyunsaturated fatty acids,
   immune response and adult diseases
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE long-chain polyunsaturated fatty acids; T cells; cytokines; atopy;
   asthma; adult diseases; perinatal programming; low-grade systemic
   inflammation; immune response
ID GAMMA-LINOLENIC ACID; INDUCED DIABETES-MELLITUS; FISH-OIL
   SUPPLEMENTATION; NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; COD-LIVER
   OIL; RHEUMATOID-ARTHRITIS; INDUCED CYTOTOXICITY; CHILDHOOD LEUKEMIA;
   GENE-EXPRESSION
AB Both omega-6 and omega-3 long-chain polyunsaturated fatty acids (LCPUFAs) modulate T(H)1 and T(H)2 cell generation, their cytokine production, and cell proliferation and thus may serve as endogenous anti-inflammatory molecules. LCPUFAs suppress the production of tumor necrosis factor-alpha (TNF-alpha) (and so also of OX40, since it belongs to the family of TNFR) and the expression of Bcl-2, suggesting that these fatty acids have the ability to prevent/suppress autoimmune diseases. Human breast milk contains substantial amounts of both omega-3 and omega-6 fatty acids. This indicates that LCPUFAs present in human breast milk suppress the levels of OX40 and decrease the expression of Bcl-x(L) and Bcl-2 on exposure to self-antigens and thus, protects against the development of autoimmune diseases in later life. In view of this, I propose that supplementation of appropriate amounts of LCPUFAs during perinatal period protects against atopy, asthma, auto-immune diseases, type 1 and type 2 diabetes mellitus, hypertension, coronary heart disease, metabolic syndrome X, lymphomas, leukemias and other cancers, schizophrenia, depression and other adult diseases in which low-grade systemic inflammation plays a significant role. It is also likely that perinatal supplementation of LCPUFAs in adequate amounts modulates the expression of genes concerned with immune response, angiogenesis, central osmo/sodium and glucose sensors etc. This renders various tissues and organs including T cells and macrophages, endothelial cells, hypothalamic neurons, and various cardiovascular tissues to be able to counteract the pathological mechanisms that tend to induce various adult diseases by blunting the inflammatory responses in those who received adequate amounts of LCPUFAs during the perinatal period compared to those who did not.
C1 UND Life Sci, Walpole, ME 02081 USA.
RP UND Life Sci, 1083 Main St, Walpole, ME 02081 USA.
EM undurti@hotmail.com
RI Das, Undurti/A-7918-2009
CR Alpert E, 2002, BIOCHEM J, V362, P413, DOI 10.1042/0264-6021:3620413
   Arvindakshan M, 2003, SCHIZOPHR RES, V62, P195, DOI 10.1016/S0920-9964(02)00284-0
   Arvindakshan M, 2003, BIOL PSYCHIAT, V53, P56, DOI 10.1016/S0006-3223(02)01443-9
   Bakshi A, 2003, NUTRITION, V19, P305, DOI 10.1016/S0899-9007(02)00862-6
   Bansal-Pakala P, 2001, NAT MED, V7, P907, DOI 10.1038/90942
   Barker D.J. P., 1992, FETAL INFANT ORIGINS
   BEGIN ME, 1986, JNCI-J NATL CANCER I, V77, P1053
   BEGIN ME, 1986, PROG LIPID RES, V25, P573, DOI 10.1016/0163-7827(86)90116-5
   Bener A, 2001, EUR J CANCER, V37, P234, DOI 10.1016/S0959-8049(00)00339-7
   BLOT WJ, 1975, JNCI-J NATL CANCER I, V55, P547, DOI 10.1093/jnci/55.3.547
   Colin A, 2003, ENCEPHALE, V29, P49
   Das U.N., 2002, A perinatal strategy for preventing adult disease: the role of long-chain polyunsaturated fatty acids: the role of long-chain polyunsaturated fatty acids
   DAS UN, 1991, PROSTAG LEUKOTR ESS, V44, P201, DOI 10.1016/0952-3278(91)90018-Z
   DAS UN, 1994, PROSTAG LEUKOTR ESS, V51, P207, DOI 10.1016/0952-3278(94)90136-8
   DAS UN, 1985, PROSTAG OTH LIPID M, V29, P911, DOI 10.1016/0090-6980(85)90216-3
   Das UN, 2003, NUTRITION, V19, P1022, DOI 10.1016/j.nut.2003.08.002
   Das UN, 2003, EUR J CLIN NUTR, V57, P218, DOI 10.1038/sj.ejcn.1601535
   Das UN, 2002, EXP BIOL MED, V227, P989, DOI 10.1177/153537020222701106
   Das UN, 2002, PROSTAG LEUKOTR ESS, V67, P1, DOI 10.1054/plef.2002.0374
   DAS UN, 1995, PROSTAG LEUKOTR ESS, V52, P387, DOI 10.1016/0952-3278(95)90066-7
   Das UN, 2001, NUTRITION, V17, P953, DOI 10.1016/S0899-9007(01)00672-4
   Das UN, 2002, NUTRITION, V18, P786, DOI 10.1016/S0899-9007(02)00840-7
   Das UN, 2000, PROSTAG LEUKOTR ESS, V63, P351, DOI 10.1054/plef.2000.0226
   Das UN, 2001, HYPERTENSION, V38, pE6, DOI 10.1161/hy0901.095926
   DAS UN, 1989, PROSTAG OTH LIPID M, V38, P689, DOI 10.1016/0090-6980(89)90050-6
   DAS UN, 1995, CANCER LETT, V94, P147, DOI 10.1016/0304-3835(95)03844-M
   David I, 1998, PROF ENG, V11, P29
   DAVIS MK, 1988, LANCET, V2, P365
   Dunstan JA, 2003, J ALLERGY CLIN IMMUN, V112, P1178, DOI 10.1016/j.jaci.2003.09.009
   Finotto S, 2002, SCIENCE, V295, P336, DOI 10.1126/science.1065544
   Fujiwara Y, 2003, J NUTR SCI VITAMINOL, V49, P125, DOI 10.3177/jnsv.49.125
   GALLI E, 1994, BRIT J DERMATOL, V130, P752, DOI 10.1111/j.1365-2133.1994.tb03413.x
   Greaves M, 1999, EUR J CANCER, V35, P1941, DOI 10.1016/S0959-8049(99)00296-8
   Greaves MF, 1997, LANCET, V349, P344, DOI 10.1016/S0140-6736(96)09412-3
   HAHN P, 1984, J NUTR, V114, P1231, DOI 10.1093/jn/114.7.1231
   Jacobsson LTH, 2003, BRIT MED J, V326, P1068, DOI 10.1136/bmj.326.7398.1068
   Joshi S, 2003, J NUTR, V133, P3170, DOI 10.1093/jn/133.10.3170
   Kitajka K, 2002, P NATL ACAD SCI USA, V99, P2619, DOI 10.1073/pnas.042698699
   Kowalski J, 2001, SCHIZOPHR RES, V50, P169, DOI 10.1016/S0920-9964(00)00156-0
   Kyle DJ, 1999, LIPIDS, V34, pS245, DOI 10.1007/BF02562306
   Latham P, 1999, CARCINOGENESIS, V20, P645, DOI 10.1093/carcin/20.4.645
   Lee JY, 2003, J LIPID RES, V44, P479, DOI 10.1194/jlr.M200361-JLR200
   Macaubas C, 2003, LANCET, V362, P1192, DOI 10.1016/S0140-6736(03)14542-4
   Mathur G P, 1993, Indian Pediatr, V30, P651
   MCCANCE RA, 1962, LANCET, V2, P671
   MOTT GE, 1991, CIBA F SYMP, V156, P56
   Nagakura T, 2000, EUR RESPIR J, V16, P861, DOI 10.1183/09031936.00.16586100
   NAIDU MRC, 1992, PROSTAG LEUKOTR ESS, V45, P181, DOI 10.1016/0952-3278(92)90110-5
   Patel MS, 2002, J BIOL CHEM, V277, P1629, DOI 10.1074/jbc.R100017200
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Puri BK, 2000, INT J CLIN PRACT, V54, P57
   Radaelli T, 2003, DIABETES, V52, P2951, DOI 10.2337/diabetes.52.12.2951
   Ranjekar PK, 2003, PSYCHIAT RES, V121, P109, DOI 10.1016/S0165-1781(03)00220-8
   REDDY BS, 1986, CANCER RES, V46, P3367
   Ridker PM, 2000, NEW ENGL J MED, V342, P836, DOI 10.1056/NEJM200003233421202
   Schloss I, 1997, S AFR MED J, V87, P152
   Shu XO, 1999, JNCI-J NATL CANCER I, V91, P1765, DOI 10.1093/jnci/91.20.1765
   Singh N K, 1987, J Assoc Physicians India, V35, P137
   Sobngwi E, 2003, LANCET, V361, P1861, DOI 10.1016/S0140-6736(03)13505-2
   Stene LC, 2000, DIABETOLOGIA, V43, P1093, DOI 10.1007/s001250051499
   Stene LC, 2003, AM J CLIN NUTR, V78, P1128, DOI 10.1093/ajcn/78.6.1128
   Su CG, 1999, J CLIN INVEST, V104, P383, DOI 10.1172/JCI7145
   Suresh Y, 2003, NUTRITION, V19, P213, DOI 10.1016/S0899-9007(02)00855-9
   Suresh Y, 2003, NUTRITION, V19, P93, DOI 10.1016/S0899-9007(02)00856-0
   Suresh Y, 2001, PROSTAG LEUKOTR ESS, V64, P37, DOI 10.1054/plef.2000.0236
   SURYAPRABHA P, 1991, PROSTAG LEUKOTR ESS, V43, P251, DOI 10.1016/0952-3278(91)90038-7
   Suzuki T, 2003, HYPERTENSION, V42, P342, DOI 10.1161/01.HYP.0000084602.06114.AD
   Szabo SJ, 2002, SCIENCE, V295, P338, DOI 10.1126/science.1065543
   Tuglu C, 2003, PSYCHOPHARMACOLOGY, V170, P429, DOI 10.1007/s00213-003-1566-z
   Vallvé JC, 2002, ATHEROSCLEROSIS, V164, P45, DOI 10.1016/S0021-9150(02)00046-1
   Vartak S, 1998, BRIT J CANCER, V77, P1612, DOI 10.1038/bjc.1998.264
   Weisinger HS, 2001, NAT MED, V7, P258, DOI 10.1038/85354
   WHINCUP PH, 2002, BRIT MED J, V324, P625
   Zhang XY, 2002, SCHIZOPHR RES, V57, P247, DOI 10.1016/S0920-9964(01)00296-1
   2003, NATURE NEUROSCIENCE, V6, P323
NR 75
TC 27
Z9 32
U1 0
U2 3
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD MAY
PY 2004
VL 10
IS 5
BP HY19
EP HY25
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 867HN
UT WOS:000224833400001
PM 15114276
DA 2025-06-11
ER

PT J
AU Norris, E
   Hamer, M
   Stamatakis, E
AF Norris, Emma
   Hamer, Mark
   Stamatakis, Emmanuel
TI Active Video Games in Schools and Effects on Physical Activity and
   Health: A Systematic Review
SO JOURNAL OF PEDIATRICS
LA English
DT Review
ID CHILDHOOD OBESITY; SEDENTARY TIME; CARDIOMETABOLIC RISK;
   ENERGY-EXPENDITURE; MENTAL-HEALTH; AGED CHILDREN; EDUCATION; YOUTH;
   ADOLESCENTS; INTENSITY
AB Objective To assess the quality of evidence for the effects of school active video game (AVG) use on physical activity and health outcomes.
   Study design Online databases (ERIC, PsycINFO, PubMed, SPORTDiscus, and Web of Science) and gray literature were searched. Inclusion criteria were the use of AVGs in school settings as an intervention; assessment of at least 1 health or physical activity outcome; and comparison of outcomes with either a control group or comparison phase. Studies featuring AVGs within complex interventions were excluded. Study quality was assessed using the Effective Public Health Practice Project tool.
   Results Twenty-two reports were identified: 11 assessed physical activity outcomes only, 5 assessed motor skill outcomes only, and 6 assessed both physical activity and health outcomes. Nine out of 14 studies found greater physical activity in AVG sessions compared with controls; mostly assessed by objective measures in school time only. Motor skills were found to improve with AVGs vs controls in all studies but not compared with other motor skill interventions. Effects of AVGs on body composition were mixed. Study quality was low in 16 studies and moderate in the remaining 6, with insufficient detail given on blinding, participation rates, and confounding variables.
   Conclusions There is currently insufficient evidence to recommend AVGs as efficacious health interventions within schools. Higher quality AVG research utilizing randomized controlled trial designs, larger sample sizes, and validated activity measurements beyond the school day is needed.
C1 [Norris, Emma; Hamer, Mark] UCL, Dept Epidemiol & Publ Hlth, Mortimer St, London WC1E 7HB, England.
   [Hamer, Mark] Univ Loughborough, Natl Ctr Sport & Exercise Med, Sch Sport Exercise & Hlth Sci, Loughborough, Leics, England.
   [Stamatakis, Emmanuel] Univ Sydney, Sydney Med Sch, Sch Publ Hlth, Charles Perkins Ctr,Prevent Res Collaborat, Sydney, NSW 2006, Australia.
   [Stamatakis, Emmanuel] Univ Sydney, Fac Hlth Sci, Sydney, NSW 2006, Australia.
C3 University of London; University College London; Loughborough
   University; University of Sydney; University of Sydney
RP Norris, E (corresponding author), UCL, Dept Epidemiol & Publ Hlth, Mortimer St, London WC1E 7HB, England.
EM e.norris.11@ucl.ac.uk
RI Norris, Emma/B-1627-2014; Stamatakis, Emmanuel/C-4958-2009; Hamer,
   Mark/C-1602-2008
OI Hamer, Mark/0000-0002-8726-7992; Norris, Emma/0000-0002-9957-4025
FU University College London Crucible doctoral studentship; National Health
   and Medical Research Council through a Senior Research Fellowship
FX E.N. is funded by a University College London Crucible doctoral
   studentship. E.S. is funded by the National Health and Medical Research
   Council through a Senior Research Fellowship. The authors declare no
   conflicts of interest.
CR Adkins M., 2013, African Journal for Physical, Health Education, Recreation and Dance, V19, P576
   Aires L, 2010, J PHYS ACT HEALTH, V7, P54, DOI 10.1123/jpah.7.1.54
   AJZEN I, 1991, ORGAN BEHAV HUM DEC, V50, P179, DOI 10.1016/0749-5978(91)90020-T
   [Anonymous], AUTISM RES TREAT
   [Anonymous], EX EV BRIEF ACT VID
   [Anonymous], J EXTENSION
   [Anonymous], 2012, Appl Physiol Nutr Metab, V37, P540, DOI DOI 10.1139/H2012-024
   [Anonymous], ACT ED GROW EV PHYS
   [Anonymous], 2014, PUBLIC HEALTH, DOI DOI 10.1186/1471-2458
   [Anonymous], HUR LABS BAL SOFTW 2
   [Anonymous], 2008, QUAL ASS TOOL QUANT
   [Anonymous], EUR TESTS PHYS FITN
   Bandura A, 2001, ANNU REV PSYCHOL, V52, P1, DOI 10.1146/annurev.psych.52.1.1
   Barnett A, 2011, J PHYS ACT HEALTH, V8, P724, DOI 10.1123/jpah.8.5.724
   Biddiss E, 2010, ARCH PEDIAT ADOL MED, V164, P664, DOI 10.1001/archpediatrics.2010.104
   Biddle SJH, 2011, BRIT J SPORT MED, V45, P886, DOI 10.1136/bjsports-2011-090185
   Bruininks RH, 2005, BruininksOseretsky Test of Motor Proficiency2nd Edition (BOT2). Circle Pines: MN: AGS Publishing, V2nd
   Campbell M, 2000, J Health Serv Res Policy, V5, P12
   Clarke J, 2013, OBES REV, V14, P975, DOI 10.1111/obr.12058
   Colley Rachel C, 2011, Health Rep, V22, P15
   Corder K, 2008, J APPL PHYSIOL, V105, P977, DOI 10.1152/japplphysiol.00094.2008
   Crocker PRE, 1997, MED SCI SPORT EXER, V29, P1344, DOI 10.1097/00005768-199710000-00011
   Dale D, 2000, RES Q EXERCISE SPORT, V71, P240, DOI 10.1080/02701367.2000.10608904
   Daley AJ, 2009, PEDIATRICS, V124, P763, DOI 10.1542/peds.2008-2357
   Duncan M., 2010, Human Movement, V11, P95, DOI [DOI 10.2478/V10038-009-0023-1, 10.2478/V10038-009-0023-1]
   Duncan M. J., 2011, Medicina Sportiva, V15, P81, DOI 10.2478/v10036-011-0014-0
   Eccles J.S., 1983, ACHIEVEMENT ACHIEVEM
   Ekelund U, 2012, JAMA-J AM MED ASSOC, V307, P704, DOI 10.1001/jama.2012.156
   Evenson KR, 2008, J SPORT SCI, V26, P1557, DOI 10.1080/02640410802334196
   Fogel VA, 2010, J APPL BEHAV ANAL, V43, P591, DOI 10.1901/jaba.2010.43-591
   Freedson P, 2005, MED SCI SPORT EXER, V37, pS523, DOI 10.1249/01.mss.0000185658.28284.ba
   Frémeaux AE, 2011, INT J OBESITY, V35, P1277, DOI 10.1038/ijo.2011.52
   Gao Z., 2013, Asian Journal of Exercise Sports Science, V10, P1
   Gao Z, 2015, J PHYS ACT HEALTH, V12, P349, DOI 10.1123/jpah.2013-0392
   Gao Z, 2014, J PHYS ACT HEALTH, V11, P992, DOI 10.1123/jpah.2012-0228
   Gao Z, 2013, AM J PREV MED, V44, pS240, DOI 10.1016/j.amepre.2012.11.023
   GODIN G, 1985, Canadian Journal of Applied Sport Sciences, V10, P141
   Green Dido, 2008, Can J Occup Ther, V75, P208
   Griffin TL, 2014, INT J BEHAV NUTR PHY, V11, DOI 10.1186/s12966-014-0112-1
   Hammond J, 2014, CHILD CARE HLTH DEV, V40, P165, DOI 10.1111/cch.12029
   Harrell J. S., 2003, Medicine & Science in Sports & Exercise, V35, pS342, DOI 10.1097/00005768-200305001-01900
   Janssen I, 2010, INT J BEHAV NUTR PHY, V7, DOI 10.1186/1479-5868-7-40
   Jelsma D, 2014, HUM MOVEMENT SCI, V33, P404, DOI 10.1016/j.humov.2013.12.007
   Lakens D, 2013, FRONT PSYCHOL, V4, DOI 10.3389/fpsyg.2013.00863
   Lanningham-Foster L, 2006, PEDIATRICS, V118, pE1831, DOI 10.1542/peds.2006-1087
   Lanningham-Foster L, 2009, J PEDIATR-US, V154, P819, DOI 10.1016/j.jpeds.2009.01.009
   LeBlanc AG, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0129622
   LeBlanc AG, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0065351
   Leyland AH, 2003, SCAND J PUBLIC HEALT, V31, P267, DOI 10.1080/14034940210165028
   Lwin MO, 2012, PSYCHOL SPORT EXERC, V13, P756, DOI 10.1016/j.psychsport.2012.04.013
   MacArthur B, 2014, GAMES HEALTH J, V3, P388, DOI 10.1089/g4h.2014.0017
   Miller TA, 2013, GAMES HEALTH J, V2, P96, DOI 10.1089/g4h.2012.0058
   Mills A, 2013, J PEDIATR-US, V163, P806, DOI 10.1016/j.jpeds.2013.03.076
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Naylor PJ, 2015, PREV MED, V72, P95, DOI 10.1016/j.ypmed.2014.12.034
   Norris E, 2015, BMC PUBLIC HEALTH, V15, DOI 10.1186/s12889-015-1706-5
   Peng W, 2013, HEALTH EDUC BEHAV, V40, P171, DOI 10.1177/1090198112444956
   Peng W, 2011, CYBERPSYCH BEH SOC N, V14, P681, DOI 10.1089/cyber.2010.0578
   Quinn M, 2013, J PEDIATR HEALTH CAR, V27, P3, DOI 10.1016/j.pedhc.2011.03.011
   Ridgers ND, 2014, MED SCI SPORT EXER, V46, P1564, DOI 10.1249/MSS.0000000000000275
   SALLIS JF, 1993, RES Q EXERCISE SPORT, V64, P25, DOI 10.1080/02701367.1993.10608775
   Saunders TJ, 2014, BRIT J NUTR, V111, P747, DOI 10.1017/S000711451300295X
   Shayne RK, 2012, J APPL BEHAV ANAL, V45, P211, DOI 10.1901/jaba.2012.45-211
   Sheehan D.P., 2012, Int J Comput Sci Sport, V11, P5, DOI DOI 10.1016/j.jshs.2013.02.002
   Sheehan DP, 2013, J SPORT HEALTH SCI, V2, P131, DOI 10.1016/j.jshs.2013.02.002
   Smith L, 2015, J EPIDEMIOL COMMUN H, V69, P309, DOI 10.1136/jech-2014-204365
   Stamatakis E, 2015, PEDIATRICS, V135, pE1432, DOI 10.1542/peds.2014-3750
   Suchert V, 2015, PREV MED, V76, P48, DOI 10.1016/j.ypmed.2015.03.026
   Thalheimer W., CALCULATE EFFECT SIZ
   Tremblay MS, 2011, INT J BEHAV NUTR PHY, V8, DOI 10.1186/1479-5868-8-98
   Trost SG, 1998, MED SCI SPORT EXER, V30, P629, DOI 10.1097/00005768-199804000-00023
   Ulrich D.A., 2000, TGMD 2 TEST GROSS MO
   van Grieken A, 2012, INT J BEHAV NUTR PHY, V9, DOI 10.1186/1479-5868-9-61
   Vernadakis N, 2015, COMPUT EDUC, V83, P90, DOI 10.1016/j.compedu.2015.01.001
   Wadsworth D., 2014, Journal of Physical Education and Sport, V14, P311
   West ST, 2014, PHYS EDUC-US, V71, P16
   Wrotniak BH, 2006, PEDIATRICS, V118, pE1758, DOI 10.1542/peds.2006-0742
   Zhu XH, 2011, PHYS EDUC SPORT PEDA, V16, P83, DOI 10.1080/17408981003712802
NR 78
TC 41
Z9 46
U1 1
U2 54
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
EI 1097-6833
J9 J PEDIATR-US
JI J. Pediatr.
PD MAY
PY 2016
VL 172
BP 40
EP +
DI 10.1016/j.jpeds.2016.02.001
PG 12
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA DK8WP
UT WOS:000375209600008
PM 26947570
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Seda, O
   Krenová, D
   Oliyarnyk, O
   Sedová, L
   Krupková, M
   Liska, F
   Chyliková, B
   Kazdová, L
   Kren, V
AF Seda, Ondrej
   Krenova, Drahomira
   Oliyarnyk, Olena
   Sedova, Lucie
   Krupkova, Michaela
   Liska, Frantisek
   Chylikova, Blanka
   Kazdova, Ludmila
   Kren, Vladimir
TI Heterozygous connexin 50 mutation affects metabolic syndrome attributes
   in spontaneously hypertensive rat
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Connexin; Animal models; Lipoprotein; Oxidative stress; Metabolic
   syndrome
ID JUNCTION INTERCELLULAR COMMUNICATION; INDUCED INSULIN-RESISTANCE;
   GAP-JUNCTION; GLUCOSE-TOLERANCE; DEXAMETHASONE; CHOLESTEROL;
   HEMICHANNELS; SECRETION; MECHANISM; CATARACT
AB Background: Several members of connexin family of transmembrane proteins were previously implicated in distinct metabolic conditions. In this study we aimed to determine the effects of complete and heterozygous form of connexin50 gene (Gja8) mutation L7Q on metabolic profile and oxidative stress parameters in spontaneously hypertensive inbred rat strain (SHR).
   Methods: Adult, standard chow-fed male rats of SHR, heterozygous SHR-Dca+/- and SHR-Dca-/-coisogenic strains were used. At the age of 4 months, dexamethasone (2.6 mu g/ml) was administered in the drinking water for three days. The lipidemic profile (cholesterol and triacylglycerol concentration in 20 lipoprotein fractions, chylomicron, VLDL, LDL and HDL particle sizes) together with 33 cytokines and hormones in serum and several oxidative stress parameters in plasma, liver, kidney and heart were assessed.
   Results: SHR and SHR-Dca-/-rats had similar concentrations of triacylglycerols and cholesterol in all major lipoprotein fractions. The heterozygotes reached significantly highest levels of total (SHR-Dca+/- : 51.3 +/- 7.2 vs. SHR: 34.5 +/- 2.4 and SHR-Dca-/-: 34.4 +/- 2.5 mg/dl, p = 0.026), chylomicron and VLDL triacylglycerols. The heterozygotes showed significantly lowest values of HDL cholesterol (40.9 +/- 2.3 mg/dl) compared both to SHR (51.8 +/- 2.2 mg/dl) and SHR-Dca-/- (48.6 +/- 2.7 mg/dl). Total and LDL cholesterol in SHR-Dca+/- was lower compared to SHR. Glucose tolerance was improved and insulin concentrations were lowest in SHR-Dca-/- (1. 11 +/- 0.20 pg/ml) in comparison with both SHR (2.32 +/- 0.49 pg/ml) and SHR-Dca+/- (3.04 +/- 0.21 pg/ml). The heterozygous rats showed profile suggestive of increased oxidative stress as well as highest serum concentrations of several pro-inflammatory cytokines including interleukins 6, 12, 17, 18 and tumor necrosis factor alpha.
   Conclusions: Our results demonstrate that connexin50 mutation in heterozygous state affects significantly the lipid profile and the oxidative stress parameters in the spontaneously hypertensive rat strain.
C1 [Seda, Ondrej; Krenova, Drahomira; Sedova, Lucie; Krupkova, Michaela; Liska, Frantisek; Chylikova, Blanka; Kren, Vladimir] Charles Univ Prague, Fac Med 1, Inst Biol & Med Genet, Albertov 4, Prague 12800 2, Czech Republic.
   [Seda, Ondrej; Sedova, Lucie] Acad Sci Czech Republ, Lab Rat Models Metab Disorders, Div BIOCEV, Inst Mol Genet, Videnska 1083, Prague 14220 4, Czech Republic.
   [Oliyarnyk, Olena; Kazdova, Ludmila] Ctr Med Expt, Inst Clin & Expt Med, Videnska 1958-9, Prague 14021 4, Czech Republic.
C3 Charles University Prague; Czech Academy of Sciences; Institute of
   Molecular Genetics of the Czech Academy of Sciences; Institute for
   Clinical & Experimental Medicine (IKEM)
RP Seda, O (corresponding author), Charles Univ Prague, Fac Med 1, Inst Biol & Med Genet, Albertov 4, Prague 12800 2, Czech Republic.; Seda, O (corresponding author), Acad Sci Czech Republ, Lab Rat Models Metab Disorders, Div BIOCEV, Inst Mol Genet, Videnska 1083, Prague 14220 4, Czech Republic.
EM ondrej.seda@lf1.cuni.cz
RI Oliyarnyk, Olena/Q-6380-2019; Seda, Ondrej/A-2058-2008; Sedova,
   Lucie/D-1089-2017; Chylikova, Blanka/D-2976-2017; Krupkova,
   Michaela/L-2373-2017; Liska, Frantisek/N-9192-2017
OI Seda, Ondrej/0000-0001-8498-5895; Sedova, Lucie/0000-0003-3783-2946;
   Oliyarnyk, Olena/0000-0002-4912-6187; Chylikova,
   Blanka/0000-0002-3439-1850; Krupkova, Michaela/0000-0002-9371-2511;
   Liska, Frantisek/0000-0002-9588-806X
FU Czech Science Foundation [GACR P301/12/0777]; Ministry of Education,
   Youth and Sports of the Czech Republic [LK11217]; Charles University in
   Prague [PRVOUK-P25/LF1/2, UNCE 204022]
FX This work was supported by Czech Science Foundation Project GACR
   P301/12/0777, Project LK11217 from the Ministry of Education, Youth and
   Sports of the Czech Republic and Charles University in Prague
   [PRVOUK-P25/LF1/2, UNCE 204022].
CR Aitman TJ, 2011, NAT REV GENET, V12, P575, DOI 10.1038/nrg3047
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Beyer EC, 2013, FRONT PHARMACOL, V4, DOI 10.3389/fphar.2013.00043
   Ciccone MM, 2014, J DIABETES METAB, V5, DOI 10.4172/2155-6156.1000364
   Ciccone MM, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/782137
   Cigliola V, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0150880
   Cummings BP, 2013, J ENDOCRINOL, V216, P207, DOI 10.1530/JOE-12-0459
   Fishilevich S, 2016, GENECARDS DATABASE, V2016, DOI [10.1093/database/baw030, DOI 10.1093/DATABASE/BAW030]
   Gao K, 2015, J CELL MOL MED, V19, P2469, DOI 10.1111/jcmm.12641
   Görbe A, 2011, AM J PHYSIOL-HEART C, V300, pH1907, DOI 10.1152/ajpheart.01242.2010
   Haefliger JA, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055198
   Hamelin R, 2009, CURR PROTEIN PEPT SC, V10, P18, DOI 10.2174/138920309787315167
   Head WS, 2012, DIABETES, V61, P1700, DOI 10.2337/db11-1312
   Krupkova M, 2013, EUR J HUM GENET S2, V21, P247
   Krupkova M, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-38
   Kurtz A, 2015, CURR OPIN PHARMACOL, V21, P1, DOI 10.1016/j.coph.2014.11.009
   Le HT, 2014, J BIOL CHEM, V289, P1345, DOI 10.1074/jbc.M113.508390
   Li T, 2015, AM J PHYSIOL-ENDOC M, V308, pE257, DOI 10.1152/ajpendo.00348.2014
   Liska F, 2008, MOL VIS, V14, P823
   Lübkemeier I, 2011, J AM SOC NEPHROL, V22, P1031, DOI 10.1681/ASN.2010101047
   Lusis AJ, 2008, NAT REV GENET, V9, P819, DOI 10.1038/nrg2468
   Malínská H, 2010, MOL CELL BIOCHEM, V335, P119, DOI 10.1007/s11010-009-0248-5
   Meda P, 2012, DIABETES, V61, P1656, DOI 10.2337/db12-0336
   NAITO C, 1993, ANN NY ACAD SCI, V676, P27, DOI 10.1111/j.1749-6632.1993.tb38723.x
   Pal JD, 1999, AM J PHYSIOL-CELL PH, V276, pC1443, DOI 10.1152/ajpcell.1999.276.6.C1443
   Pfenniger A, 2013, BBA-BIOMEMBRANES, V1828, P157, DOI 10.1016/j.bbamem.2012.05.011
   Pogoda K, 2016, BMC CELL BIOL, V17, DOI 10.1186/s12860-016-0099-3
   Rafacho A, 2007, CAN J PHYSIOL PHARM, V85, P536, DOI 10.1139/Y07-037
   Rubinos C, 2014, AM J PHYSIOL-CELL PH, V306, pC212, DOI 10.1152/ajpcell.00098.2013
   Sáez JC, 2014, FEBS LETT, V588, P1205, DOI 10.1016/j.febslet.2014.03.004
   Samarasinghe RA, 2011, P NATL ACAD SCI USA, V108, P16657, DOI 10.1073/pnas.1102821108
   Seda O, 2005, CURR OPIN MOL THER, V7, P583
   Seda O, 2005, PHYSIOL GENOMICS, V21, P243, DOI 10.1152/physiolgenomics.00230.2004
   Seda O, 2008, PHARMACOGENOMICS, V9, P141, DOI 10.2217/14622416.9.2.141
   Sedová L, 2012, HEREDITY, V109, P63, DOI 10.1038/hdy.2012.14
   Shimoyama M, 2015, NUCLEIC ACIDS RES, V43, pD743, DOI 10.1093/nar/gku1026
   Shuja Z, 2016, J INVEST DERMATOL, V136, P225, DOI 10.1038/JID.2015.389
   Slavi N, 2014, J BIOL CHEM, V289, DOI 10.1074/jbc.M114.597898
   Tong JJ, 2011, AM J PHYSIOL-CELL PH, V300, pC1055, DOI 10.1152/ajpcell.00384.2010
   Usui S, 2002, J LIPID RES, V43, P805
   Xin L, 2013, FRONT PHYSIOL, V4, DOI 10.3389/fphys.2013.00373
   Xin L, 2012, J PHYSIOL-LONDON, V590, P5037, DOI 10.1113/jphysiol.2012.235507
   Yu G, 2010, FREE RADICAL BIO MED, V49, P1008, DOI 10.1016/j.freeradbiomed.2010.06.005
NR 43
TC 2
Z9 2
U1 0
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD NOV 21
PY 2016
VL 15
AR 199
DI 10.1186/s12944-016-0376-3
PG 9
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA ED3TA
UT WOS:000388770200001
PM 27871290
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rangel-Huerta, OD
   Aguilera, CM
   Martin, MV
   Soto, MJ
   Rico, MC
   Vallejo, F
   Tomas-Barberan, F
   Perez-De-La-Cruz, AJ
   Gil, A
   Mesa, MD
AF Rangel-Huerta, Oscar D.
   Aguilera, Concepcion M.
   Martin, Maria V.
   Soto, Maria J.
   Rico, Maria C.
   Vallejo, Fernando
   Tomas-Barberan, Francisco
   Perez-de-la-Cruz, Antonio J.
   Gil, Angel
   Mesa, Maria D.
TI Normal or High Polyphenol Concentration in Orange Juice Affects
   Antioxidant Activity, Blood Pressure, and Body Weight in Obese or
   Overweight Adults
SO JOURNAL OF NUTRITION
LA English
DT Article
DE antioxidants; flavanones; obesity; orange juice; oxidative stress
ID OXIDATIVE STRESS; GLUCOSYL HESPERIDIN; CITRUS FLAVONOIDS; VITAMIN-E;
   NARINGIN; CHOLESTEROL; BIOMARKERS; HESPERETIN; SUPPLEMENTATION;
   METABOLITES
AB Background: The consumption of orange juice may lead to reduced oxidative stress and may enhance the antioxidant defense system.
   Objective: The aim was to evaluate the effects of the intake of orange juice containing either normal (NPJ) or high (HPJ) concentrations of polyphenols (299 and 745 mg/d, respectively) on the antioxidant defense system, oxidative stress biomarkers, and clinical signs of metabolic syndrome in 100 nonsmoking subjects who were either overweight or obese.
   Methods: A randomized, double-blind crossover study was conducted over two 12-wk periods with a 7-wk washout period. The effects on enzymatic and nonenzymatic blood antioxidant defense systems, urinary and plasma oxidative stress biomarkers, and clinical signs of metabolic syndrome were evaluated before and after an intervention with both of the orange juices. Paired t tests and linear mixed-effects models were used to evaluate the effects of juice, time, and interactions.
   Results: The intake of either NPJ or HPJ led to a decrease in urinary 8-hydroxy-2'-deoxyguanosine (NPJ: 935 +/- 134 to 298 +/- 19 ng/mg creatinine; HPJ: 749 +/- 84 to 285 +/- 17 ng/mg creatinine), 8-iso-prostaglandin F2 alpha (NPJ: 437 +/- 68 to 156 +/- 14 ng/mg creatinine; HPJ: 347 +/- 43 to 154 +/- 13 ng/mg creatinine), erythrocyte catalase, and glutathione reductase activities. A decrease was also observed in body mass index, waist circumference, and leptin (all P < 0.051) The NPJ intervention decreased systolic and diastolic blood pressures (systolic blood pressure: 128 +/- 1 to 124 +/- 2 mm Hg; diastolic blood pressure: 79 +/- 1 to 76 +/- 1 mm Hg), whereas the HPJ intervention increased erythrocyte superoxide dismutase (SOD) activity (17.7 +/- 1.5 to 23.1 +/- 1.7 U/mg hemoglobin).
   Conclusions: Our results show that the consumption of either NPJ or HPJ protected against DNA damage and lipid peroxidation, modified several antioxidant enzymes, and reduced body weight in overweight or obese nonsmoking adults. Only blood pressure and SOD activity were influenced differently by the different flavanone supplementations.
C1 [Rangel-Huerta, Oscar D.; Aguilera, Concepcion M.; Martin, Maria V.; Rico, Maria C.; Gil, Angel; Mesa, Maria D.] Univ Granada, Ctr Biomed Res, Inst Nutr & Food Technol Jose Mataix, Dept Biochem & Mol Biol 2, Granada, Spain.
   [Soto, Maria J.] Ctr Studies Sensory Impairment Aging & Metab, Guatemala City, Guatemala.
   [Vallejo, Fernando; Tomas-Barberan, Francisco] Ctr Soil Sci & Appl Biol Segura Superior Council, Dept Food Sci & Technol, Res Grp Qual Safety & Bioact Plant Foods, Murcia, Spain.
   [Perez-de-la-Cruz, Antonio J.] Univ Hosp Virgen Nieves, Granada, Spain.
C3 University of Granada; Consejo Superior de Investigaciones Cientificas
   (CSIC); CSIC - Centro de Edafologia y Biologia Aplicada del Segura
   (CEBAS); Hospital Universitario Virgen de las Nieves
RP Gil, A (corresponding author), Univ Granada, Ctr Biomed Res, Inst Nutr & Food Technol Jose Mataix, Dept Biochem & Mol Biol 2, Granada, Spain.
EM agil@ugr.es
RI Gil, Angel/L-2275-2014; Rico Prados/G-4601-2016; Soto Mendez, Maria
   Jose/U-1639-2017; Mesa, Maria/M-3523-2014; Tomas-Barberan,
   Francisco/D-6686-2011; Aguilera, Concepcion/M-1663-2014; Rangel Huerta,
   Oscar Daniel/I-4019-2015
OI Gil, Angel/0000-0001-7663-0939; Rico Prados/0000-0001-7742-5742; Soto
   Mendez, Maria Jose/0000-0002-1012-4715; Mesa, Maria/0000-0003-4079-6464;
   Tomas-Barberan, Francisco/0000-0002-0790-1739; Aguilera,
   Concepcion/0000-0002-1451-4788; Rangel Huerta, Oscar
   Daniel/0000-0001-8585-0108; Vallejo, Fernando/0000-0003-3343-6479
FU University of Granada Enterprise General Foundation [3345]; Coca-Cola
   Europe [3345]
FX Supported by research contract 3345 between the University of Granada
   Enterprise General Foundation and Coca-Cola Europe.
CR Aebi H, 1984, Methods Enzymol, V105, P121
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Assini JM, 2013, CURR OPIN LIPIDOL, V24, P34, DOI 10.1097/MOL.0b013e32835c07fd
   Bernabé J, 2013, J FUNCT FOODS, V5, P1031, DOI 10.1016/j.jff.2013.02.003
   CARLBERG I, 1985, METHOD ENZYMOL, V113, P484
   Carocho M, 2013, FOOD CHEM TOXICOL, V51, P15, DOI 10.1016/j.fct.2012.09.021
   Choi EJ, 2008, LIFE SCI, V82, P1059, DOI 10.1016/j.lfs.2008.03.002
   Cilla A, 2009, ANN NUTR METAB, V54, P35, DOI 10.1159/000205318
   Codoñer-Franch P, 2008, J PEDIATR GASTR NUTR, V47, P349, DOI 10.1097/MPG.0b013e31816a8cdb
   Dalgård C, 2009, BRIT J NUTR, V101, P263, DOI 10.1017/S0007114508995660
   Demonty I, 2010, J NUTR, V140, P1615, DOI 10.3945/jn.110.124735
   DRABKIN DL, 1948, AM J MED SCI, V215, P110, DOI 10.1097/00000441-194801000-00017
   FLOHE L, 1984, METHOD ENZYMOL, V105, P114
   Galati G, 2004, FREE RADICAL BIO MED, V37, P287, DOI 10.1016/j.freeradbiomed.2004.04.034
   Galleano M, 2012, ANN NY ACAD SCI, V1259, P87, DOI 10.1111/j.1749-6632.2012.06511.x
   Garg A, 2001, PHYTOTHER RES, V15, P655, DOI 10.1002/ptr.1074
   Hollman PCH, 2011, J NUTR, V141, p989S, DOI 10.3945/jn.110.131490
   Jain M, 2011, INFLAMM RES, V60, P483, DOI 10.1007/s00011-010-0295-0
   Jeon SM, 2002, CLIN CHIM ACTA, V317, P181, DOI 10.1016/S0009-8981(01)00778-1
   Jeon SM, 2001, LIFE SCI, V69, P2855, DOI 10.1016/S0024-3205(01)01363-7
   Jomova K, 2013, EUR J MED CHEM, V70, P102, DOI 10.1016/j.ejmech.2013.09.054
   Kawashima A, 2007, ASIA PAC J CLIN NUTR, V16, P411
   Kurowska EM, 2000, AM J CLIN NUTR, V72, P1095
   Landete JM, 2013, CRIT REV FOOD SCI, V53, P706, DOI 10.1080/10408398.2011.555018
   Lobo V, 2010, Pharmacogn Rev, V4, P118, DOI 10.4103/0973-7847.70902
   Mahmoud AM, 2012, J DIABETES COMPLICAT, V26, P483, DOI 10.1016/j.jdiacomp.2012.06.001
   Martinez Cayuela M, 2010, TREATY NUTR PHYSL BI, V1, P455
   MARTINMORENO JM, 1993, INT J EPIDEMIOL, V22, P512, DOI 10.1093/ije/22.3.512
   MCCORD JM, 1969, J BIOL CHEM, V244, P6056
   Miwa Y, 2005, J NUTR SCI VITAMINOL, V51, P460, DOI 10.3177/jnsv.51.460
   Morand C, 2011, AM J CLIN NUTR, V93, P73, DOI 10.3945/ajcn.110.004945
   Mulvihill EE, 2009, DIABETES, V58, P2198, DOI 10.2337/db09-0634
   Niki E, 2014, FREE RADICAL BIO MED, V66, P3, DOI 10.1016/j.freeradbiomed.2013.03.022
   Pérez DD, 2002, ANN NY ACAD SCI, V957, P136, DOI 10.1111/j.1749-6632.2002.tb02912.x
   Pérez-Jiménez J, 2010, AM J CLIN NUTR, V92, P801, DOI 10.3945/ajcn.2010.29924
   Perron NR, 2011, J INORG BIOCHEM, V105, P745, DOI 10.1016/j.jinorgbio.2011.02.009
   POND AL, 1994, B ENVIRON CONTAM TOX, V53, P562
   Rajadurai M, 2009, PHYTOTHER RES, V23, P358, DOI 10.1002/ptr.2632
   Roowi S, 2009, MOL NUTR FOOD RES, V53, pS68, DOI 10.1002/mnfr.200800287
   Sánchez-Moreno C, 2003, AM J CLIN NUTR, V78, P454, DOI 10.1093/ajcn/78.3.454
   Schaer MY, 2015, AM J CLIN NUTR, V101, P931, DOI 10.3945/ajcn.114.104364
   Shi XP, 2012, MOLECULES, V17, P12868, DOI 10.3390/molecules171112868
   Tirkey Naveen, 2005, BMC Pharmacology, V5, P2, DOI 10.1186/1471-2210-5-2
   Tomás-Navarro M, 2014, J AGR FOOD CHEM, V62, P24, DOI 10.1021/jf4048989
   Tsai SJ, 2012, J AGR FOOD CHEM, V60, P514, DOI 10.1021/jf203259h
   University of Granada, 2010, SPAN DAT FOOD COMP B
   Wilcox LJ, 2001, J LIPID RES, V42, P725
   Wilmsen PK, 2005, J AGR FOOD CHEM, V53, P4757, DOI 10.1021/jf0502000
   Wu LL, 2004, CLIN CHIM ACTA, V339, P1, DOI 10.1016/j.cccn.2003.09.010
   Yamamoto M, 2008, J NUTR SCI VITAMINOL, V54, P95, DOI 10.3177/jnsv.54.95
   Yen GC, 2003, BIOSCI BIOTECH BIOCH, V67, P1215, DOI 10.1271/bbb.67.1215
NR 51
TC 105
Z9 108
U1 0
U2 33
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD AUG
PY 2015
VL 145
IS 8
BP 1808
EP 1816
DI 10.3945/jn.115.213660
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CO3DT
UT WOS:000359037500018
PM 26136593
OA Bronze
DA 2025-06-11
ER

PT J
AU Aguglia, A
   Signorelli, MS
   Albert, U
   Maina, G
AF Aguglia, Andrea
   Signorelli, Maria Salvina
   Albert, Umberto
   Maina, Giuseppe
TI The Impact of General Medical Conditions in Obsessive-Compulsive
   Disorder
SO PSYCHIATRY INVESTIGATION
LA English
DT Article
DE Obsessive-compulsive disorder; General medical condition; Cardiovascular
   disease; Duration of untreated illness; Medical illness
ID METABOLIC SYNDROME; ANXIETY DISORDERS; BIPOLAR DISORDER; UNTREATED
   ILLNESS; WEIGHT-GAIN; FOLLOW-UP; DEPRESSION; PREVALENCE; RISK; SYMPTOMS
AB Objective The co-occurrence of general medical conditions (GMCs) and major psychiatric disorders is well documented. The aim of this study was to assess the prevalence of GMCs in patients with a primary diagnosis of obsessive-compulsive disorder (OCD) and, secondly, to investigate which clinical variables are associated with the presence of a GMC.
   Methods Subjects with a primary diagnosis of OCD were included. Socio-demographic and clinical characteristics were collected. GMCs were classified using the ICD-10 and grouped according to the Cumulative Illness Rating Scale (CIRS) in: cardiac, vascular, hematopoietic, respiratory, ear/nose/throat, upper and lower gastrointestinal, hepatic, renal, genitourinary, musculoskeletal, neurologic, endocrine/metabolic. The association between the presence of GMCs and demographic/clinical variables of OCD was investigated.
   Results A total of 162 patients with OCD were included. 78 (48.1%) patients had at least one comorbid GMC. Most frequent GMCs were endocrine/metabolic diseases (25.9%), followed by upper/lower gastrointestinal (20.5%) and cardio-vascular diseases (13.6%). The presence of a GMC was significantly associated with female gender, older age, duration of untreated illness (DUI), and absence of physical activity.
   Conclusion Patients with OCD have high rates of comorbid GMCs. A longer DUI is associated with having at least one GMCs; this might be due to the long-lasting adoption of unhealthy lifestyles, not counterbalanced by appropriate treatment and psychoeducation.
C1 [Aguglia, Andrea; Albert, Umberto; Maina, Giuseppe] Univ Turin, San Luigi Gonzaga Hosp, Rita Levi Montalcini Dept Neurosci, Psychiat Unit, Reg Gonzole 10, I-10043 Turin, Italy.
   [Signorelli, Maria Salvina] Univ Catania, AOU Policlin Hosp, Dept Clin & Expt Med, Catania, Italy.
C3 Azienda Ospedaliero-Universitaria San Luigi Gonzaga; University of
   Turin; University of Catania
RP Aguglia, A (corresponding author), Univ Turin, San Luigi Gonzaga Hosp, Rita Levi Montalcini Dept Neurosci, Psychiat Unit, Reg Gonzole 10, I-10043 Turin, Italy.
EM andrea.aguglia@unito.it
RI Maina, Giuseppe/AAC-7158-2022; Signorelli, Maria Salvina/E-6155-2010;
   Salvina, Maria/E-6155-2010
OI Aguglia, Andrea/0000-0002-2003-2101; Signorelli, Maria
   Salvina/0000-0001-5835-4176; Salvina, Maria/0000-0002-6941-9454
CR Aguglia A, 2011, J AFFECT DISORDERS, V128, P262, DOI 10.1016/j.jad.2010.07.004
   Albert U, 2013, GEN HOSP PSYCHIAT, V35, P154, DOI 10.1016/j.genhosppsych.2012.10.004
   [Anonymous], MED CLIN MONOGR BARC
   Balkau B, 2003, DIABETES METAB, V29, P526, DOI 10.1016/S1262-3636(07)70067-8
   Barnard K, 2013, DIABETES CARE, V36, P3337, DOI 10.2337/dc13-0560
   Carroll D, 2009, BIOL PSYCHIAT, V66, P91, DOI 10.1016/j.biopsych.2009.02.020
   Chalfoun C, 2016, J SPORT SCI, V34, P1500, DOI 10.1080/02640414.2015.1119875
   Chong SA, 2012, ANN ACAD MED SINGAP, V41, P105
   Cosci F, 2015, PSYCHOTHER PSYCHOSOM, V84, P22, DOI 10.1159/000367913
   Crump C, 2013, JAMA PSYCHIAT, V70, P931, DOI 10.1001/jamapsychiatry.2013.1394
   Culpepper L, 2009, J CLIN PSYCHIAT, V70, P20, DOI 10.4088/JCP.s.7002.04
   De Hert M, 2009, EUR PSYCHIAT, V24, P412, DOI 10.1016/j.eurpsy.2009.01.005
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   Dell'Osso B, 2010, WORLD J BIOL PSYCHIA, V11, P59, DOI 10.3109/15622970903418544
   Dell'Osso B, 2015, CNS SPECTRUMS, V20, P474, DOI 10.1017/S1092852914000339
   Drummond LM, 2012, GEN HOSP PSYCHIAT, V34, P618, DOI 10.1016/j.genhosppsych.2012.02.001
   Fagiolini A, 2009, J CLIN PSYCHIAT, V70, P22, DOI 10.4088/JCP.7075su1c.04
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   Goulart AC, 2014, HEADACHE, V54, P1310, DOI 10.1111/head.12397
   Guan NH, 2010, PSYCHIAT CLIN NEUROS, V64, P625, DOI 10.1111/j.1440-1819.2010.02150.x
   Heppner PS, 2009, BMC MED, V7, DOI 10.1186/1741-7015-7-1
   Hu G, 2004, ARCH INTERN MED, V164, P1066, DOI 10.1001/archinte.164.10.1066
   Jakovljevic M, 2008, PSYCHIAT DANUB, V20, P406
   Jayakody K, 2014, BRIT J SPORT MED, V48, P187, DOI 10.1136/bjsports-2012-091287
   Katon W, 2007, GEN HOSP PSYCHIAT, V29, P147, DOI 10.1016/j.genhosppsych.2006.11.005
   Kessler RC, 2004, INT J METH PSYCH RES, V13, P69, DOI 10.1002/mpr.167
   Kinley DJ, 2015, GEN HOSP PSYCHIAT, V37, P288, DOI 10.1016/j.genhosppsych.2015.03.022
   LINN BS, 1968, J AM GERIATR SOC, V16, P622, DOI 10.1111/j.1532-5415.1968.tb02103.x
   Magalhaes PV, 2012, ACTA PSYCHIAT SCAND, V125, P303, DOI 10.1111/j.1600-0447.2011.01794.x
   Maina G, 2004, J CLIN PSYCHIAT, V65, P1365, DOI 10.4088/JCP.v65n1011
   Maina G, 2013, PSYCHOSOMATICS, V54, P437, DOI 10.1016/j.psym.2012.10.011
   Mansur RB, 2015, NEUROSCI BIOBEHAV R, V52, P89, DOI 10.1016/j.neubiorev.2014.12.017
   Matsunaga H, 2009, J CLIN PSYCHIAT, V70, P863, DOI 10.4088/JCP.08m04369
   Miccoli R, 2005, NUTR METAB CARDIOVAS, V15, P250, DOI 10.1016/j.numecd.2004.09.002
   Murray CJL, 2013, JAMA-J AM MED ASSOC, V310, P591, DOI 10.1001/jama.2013.13805
   Mussell M, 2008, J PSYCHOSOM RES, V64, P605, DOI 10.1016/j.jpsychores.2008.02.019
   Niles AN, 2015, J PSYCHOSOM RES, V78, P109, DOI 10.1016/j.jpsychores.2014.11.018
   Osborn DPJ, 2007, ARCH GEN PSYCHIAT, V64, P242, DOI 10.1001/archpsyc.64.2.242
   Panagiotakos DB, 2008, ANN EPIDEMIOL, V18, P387, DOI 10.1016/j.annepidem.2007.11.002
   Poyraz CA, 2015, COMPR PSYCHIAT, V58, P88, DOI 10.1016/j.comppsych.2014.12.019
   Roy-Byrne PP, 2008, GEN HOSP PSYCHIAT, V30, P208, DOI 10.1016/j.genhosppsych.2007.12.006
   Salcedo S, 2016, J AFFECT DISORDERS, V201, P203, DOI 10.1016/j.jad.2016.05.018
   Salvi V, 2016, EUR NEUROPSYCHOPHARM, V26, P1673, DOI 10.1016/j.euroneuro.2016.08.012
   Salvi V, 2016, PSYCHOPHARMACOLOGY, V233, P49, DOI 10.1007/s00213-015-4085-9
   Salvi V, 2012, J AFFECT DISORDERS, V136, P599, DOI 10.1016/j.jad.2011.10.025
   Sareen J, 2006, ARCH INTERN MED, V166, P2109, DOI 10.1001/archinte.166.19.2109
   Scott KM, 2007, J AFFECT DISORDERS, V103, P113, DOI 10.1016/j.jad.2007.01.015
   Scott KM, 2014, CURR OPIN PSYCHIATR, V27, P289, DOI 10.1097/YCO.0000000000000067
   Serretti A, 2010, J CLIN PSYCHIAT, V71, P1259, DOI 10.4088/JCP.09r05346blu
   Siddiqui F, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-502
   Sylvia LG, 2013, INT J BIPOLAR DISORD, V1, DOI 10.1186/2194-7511-1-24
   Sylvia LG, 2011, J PSYCHIATR PRACT, V17, P224, DOI 10.1097/01.pra.0000398419.82362.32
   Weber NS, 2011, PSYCHIAT SERV, V62, P1152, DOI 10.1176/ps.62.10.pss6210_1152
   Weiss T, 2011, GEN HOSP PSYCHIAT, V33, P135, DOI 10.1016/j.genhosppsych.2011.01.002
   Witthauer C, 2014, SOC PSYCH PSYCH EPID, V49, P2013, DOI 10.1007/s00127-014-0895-z
   Yates WR, 2004, GEN HOSP PSYCHIAT, V26, P421, DOI 10.1016/j.genhosppsych.2004.06.008
NR 56
TC 33
Z9 40
U1 0
U2 3
PU KOREAN NEUROPSYCHIATRIC ASSOC
PI SEOUL
PA RN 522, G-FIVE CENTRAL PLAZA 1685-8 SEOCHO 4-DONG, SEOCHO-GU, SEOUL,
   137-882, SOUTH KOREA
SN 1738-3684
EI 1976-3026
J9 PSYCHIAT INVEST
JI Psychiatry Investig.
PD MAR
PY 2018
VL 15
IS 3
BP 246
EP 253
DI 10.30773/pi.2017.06.17.2
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FZ6BQ
UT WOS:000427682300004
PM 29475243
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Steen, VM
   Nepal, C
   Ersland, KM
   Holdhus, R
   Nævdal, M
   Ratvik, SM
   Skrede, S
   Håvik, B
AF Steen, Vidar M.
   Nepal, Chirag
   Ersland, Kari M.
   Holdhus, Rita
   Naevdal, Marianne
   Ratvik, Siri M.
   Skrede, Silje
   Havik, Bjarte
TI Neuropsychological Deficits in Mice Depleted of the Schizophrenia
   Susceptibility Gene CSMD1
SO PLOS ONE
LA English
DT Article
ID DRUG-NAIVE; RNA; ASSOCIATION; POPULATION; MOLECULES; KINASE
AB Recent meta-analyses of schizophrenia genome-wide association studies (GWASs) have identified the CUB and SUSHI multiple domains 1 (CSMD1) gene as a statistically strong risk factor. CSMD1 is a complement control-related protein suggested to inhibit the classical complement pathway, being expressed in developing neurons. However, expression of CSMD1 is largely uncharacterized and relevance for behavioral phenotypes is not previously demonstrated. Here, we assess neuropsychological behaviors of a Csmd1 knockout (KO) mouse in a selection of standard behavioral tests. Deregulation of neuropsychological responses were observed in both the open field and the elevated plus maze tests, in which KO mice spent 55% and 33% less time than WT littermate mice in open areas, respectively. Altered behaviors were also observed in tail suspension and to higher acoustic stimuli, for which Csmd1 KO mice showed helplessness and moderate increase in startle amplitude, respectively. Furthermore, Csmd1 KO mice also displayed increased weight-gain and glucose tolerance, similar to a major phenotype of the metabolic syndrome that also has been associated to the human CSMD1 locus. Consistent with a role in the control of behaviors, Csmd1 was found highly expressed in the central nervous system (CNS), and with some expression in visceral fat and ovary, under tissue-specific control by a novel promoter-associated lncRNA. In summary, disruption of Csmd1 induces behaviors reminiscent of blunted emotional responses, anxiety and depression. These observations suggest an influence of the CSMD1 schizophrenia susceptibility gene on psychopathology and endophenotypes of the negative symptom spectra.
C1 [Steen, Vidar M.; Nepal, Chirag; Ersland, Kari M.; Holdhus, Rita; Naevdal, Marianne; Ratvik, Siri M.; Skrede, Silje; Havik, Bjarte] Univ Bergen, Dr E Martens Res Grp Biol Psychiat, Bergen, Norway.
   [Steen, Vidar M.; Nepal, Chirag; Ersland, Kari M.; Holdhus, Rita; Naevdal, Marianne; Ratvik, Siri M.; Skrede, Silje; Havik, Bjarte] Univ Bergen, KG Jebsen Ctr Psychosis Res, Dept Clin Sci, Bergen, Norway.
   [Steen, Vidar M.; Nepal, Chirag; Ersland, Kari M.; Holdhus, Rita; Naevdal, Marianne; Ratvik, Siri M.; Skrede, Silje; Havik, Bjarte] Haukeland Hosp, Ctr Med Genet & Mol Med, N-5021 Bergen, Norway.
C3 University of Bergen; University of Bergen; University of Bergen;
   Haukeland University Hospital
RP Håvik, B (corresponding author), Univ Bergen, Dr E Martens Res Grp Biol Psychiat, Bergen, Norway.
EM bjarte.haavik@uib.no
RI Nepal, Chirag/K-5866-2019; Skrede, Silje/AAA-4453-2019
OI Ersland, Kari Merete/0000-0003-3674-4151; Nepal,
   Chirag/0000-0001-8402-3805
FU Research Council of Norway (Psykisk Helse Grant) [186001]; Research
   Council of Norway (FUGE Grant) [151904, 183327]; Bergen Medical Research
   Foundation (BMFS); Kristian Gerhard Jebsen Foundation; Helse Vest RHF;
   Dr. Einar Martens Fund
FX This study was supported by the Research Council of Norway (Psykisk
   Helse Grant No. 186001 and the FUGE Grant Nos. 151904 and 183327),
   Bergen Medical Research Foundation (BMFS), The Kristian Gerhard Jebsen
   Foundation, Helse Vest RHF and Dr. Einar Martens Fund. The funders had
   no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
CR Anders S, 2010, GENOME BIOL, V11, DOI 10.1186/gb-2010-11-10-r106
   Baum AE, 2008, MOL PSYCHIATR, V13, P197, DOI 10.1038/sj.mp.4002012
   de Morentin PBM, 2011, REV ENDOCR METAB DIS, V12, P127, DOI 10.1007/s11154-011-9165-5
   Braff DL, 2001, SCHIZOPHR RES, V49, P171, DOI 10.1016/S0920-9964(00)00139-0
   Brown AS, 2006, SCHIZOPHRENIA BULL, V32, P200, DOI 10.1093/schbul/sbj052
   Carrieri C, 2012, NATURE, V491, P454, DOI 10.1038/nature11508
   Cryan JF, 2005, NEUROSCI BIOBEHAV R, V29, P571, DOI 10.1016/j.neubiorev.2005.03.009
   Datwani A, 2009, NEURON, V64, P463, DOI 10.1016/j.neuron.2009.10.015
   Dernovsek MZ, 2009, PSYCHIAT DANUB, V21, P43
   Distler MG, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051235
   Escudero-Esparza A, 2013, FASEB J, V27, P5083, DOI 10.1096/fj.13-230706
   Ferno J, 2011, FRONT BIOSCI-LANDMRK, V16, P49, DOI 10.2741/3675
   Friddle CJ, 2003, COLD SPRING HARB SYM, V68, P311, DOI 10.1101/sqb.2003.68.311
   Håvik B, 2007, NEUROSCIENCE, V148, P925, DOI 10.1016/j.neuroscience.2007.07.024
   Håvik B, 2011, BIOL PSYCHIAT, V70, P35, DOI 10.1016/j.biopsych.2011.01.030
   Juutinen J, 2008, EUR PSYCHIAT, V23, P521, DOI 10.1016/j.eurpsy.2008.06.002
   Kendler KS, 2010, MOL PSYCHIATR, V15, P789, DOI 10.1038/mp.2010.8
   Kirkitadze MD, 2001, IMMUNOL REV, V180, P146, DOI 10.1034/j.1600-065X.2001.1800113.x
   Kirkpatrick B, 2012, SCHIZOPHRENIA BULL, V38, P280, DOI 10.1093/schbul/sbq058
   Koch M, 1997, BEHAV BRAIN RES, V89, P35, DOI 10.1016/S0166-4328(97)02296-1
   Kraus DM, 2006, J IMMUNOL, V176, P4419, DOI 10.4049/jimmunol.176.7.4419
   Lichtenstein P, 2009, LANCET, V373, P234, DOI 10.1016/S0140-6736(09)60072-6
   Liu J, 2012, NAT NEUROSCI, V15, P1621, DOI 10.1038/nn.3263
   Makinodan M, 2012, SCIENCE, V337, P1357, DOI 10.1126/science.1220845
   Matsui M, 2013, ACS CHEM BIOL, V8, P122, DOI 10.1021/cb300490j
   Mouse ENCODE Consortium, 2012, Genome Biol, V13, P418, DOI 10.1186/gb-2012-13-8-418
   Nock Nora L, 2009, BMC Proc, V3 Suppl 7, pS50
   Ramos PS, 2012, ARTHRITIS RHEUM-US, V64, P4060, DOI 10.1002/art.34663
   Ripke S, 2011, NAT GENET, V43, P969, DOI 10.1038/ng.940
   Ritsner MS, 2007, QUALITY LIFE IMPAIRM, P388
   Schafer DP, 2013, GLIA, V61, P24, DOI 10.1002/glia.22389
   Schafer DP, 2012, NEURON, V74, P691, DOI 10.1016/j.neuron.2012.03.026
   Schafer DP, 2010, BIOCHEM SOC T, V38, P476, DOI 10.1042/BST0380476
   Schulze TG, 2012, WORLD J BIOL PSYCHIA, P1
   Shatz CJ, 2009, NEURON, V64, P40, DOI 10.1016/j.neuron.2009.09.044
   Sklar P, 2008, MOL PSYCHIATR, V13, P558, DOI 10.1038/sj.mp.4002151
   Stevens B, 2007, CELL, V131, P1164, DOI 10.1016/j.cell.2007.10.036
   Sullivan PF, 2009, MOL PSYCHIATR, V14, P359, DOI 10.1038/mp.2008.125
   Sullivan PF, 2012, NAT REV GENET, V13, P537, DOI 10.1038/nrg3240
   Sun PC, 2001, GENOMICS, V75, P17, DOI 10.1006/geno.2001.6587
   Swerdlow NR, 2000, BEHAV PHARMACOL, V11, P185, DOI 10.1097/00008877-200006000-00002
   Thakore JH, 2002, INT J OBESITY, V26, P137, DOI 10.1038/sj.ijo.0801840
   Trapnell C, 2010, NAT BIOTECHNOL, V28, P511, DOI 10.1038/nbt.1621
   Trapnell C, 2009, BIOINFORMATICS, V25, P1105, DOI 10.1093/bioinformatics/btp120
   Tye KM, 2011, NATURE, V471, P358, DOI 10.1038/nature09820
   Wagner E, 2010, NAT REV DRUG DISCOV, V9, P43, DOI 10.1038/nrd3011
   Williams KW, 2012, NAT NEUROSCI, V15, P1350, DOI 10.1038/nn.3217
NR 47
TC 58
Z9 68
U1 0
U2 65
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 14
PY 2013
VL 8
IS 11
AR e79501
DI 10.1371/journal.pone.0079501
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 254DJ
UT WOS:000327143800084
PM 24244513
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Ginis, KAM
   van der Ploeg, HP
   Foster, C
   Lai, B
   McBride, CB
   Ng, K
   Pratt, M
   Shirazipour, CH
   Smith, B
   Vásquez, PM
   Heath, GW
AF Ginis, Kathleen A. Martin
   van der Ploeg, Hidde P.
   Foster, Charlie
   Lai, Byron
   McBride, Christopher B.
   Ng, Kwok
   Pratt, Michael
   Shirazipour, Celina H.
   Smith, Brett
   Vasquez, Priscilla M.
   Heath, Gregory W.
TI Participation of people living with disabilities in physical activity: a
   global perspective
SO LANCET
LA English
DT Review
ID ACTIVITY QUESTIONNAIRE; INTELLECTUAL DISABILITIES; CEREBRAL-PALSY;
   SHORT-FORM; CHILDREN; INTERVENTIONS; INDIVIDUALS; HEALTH; METAANALYSIS;
   ADULTS
AB Approximately 1.5 billion people worldwide live with a physical, mental, sensory, or intellectual disability, about 80% of which are in low-income and middle-income countries. This Series paper provides a global overview of the prevalence, benefits, and promotion policies for physical activity for people living with disabilities (PLWD). PLWD are 16-62% less likely to meet physical activity guidelines and are at higher risk of serious health problems related to inactivity than people without disabilities. Meta-analyses have shown that physical activity has beneficial effects on cardiovascular fitness (average standardised mean difference [SMD] 0.69 [95% CI 0.31-1.01]), musculoskeletal fitness (0.59 [0.31-0.87]), cardiometabolic risk factors (0.39 [0.04-0.75]), and brain and mental health outcomes (0.47 [0.21-0.73]). These meta-analyses also show that health benefits can be achieved even with less than 150 min of physical activity per week, and suggest that some physical activity is better than none. Meta-analyses of interventions to increase physical activity for PLWD have reported effect sizes ranging from SMD 0.29 (95% CI 0.17-0.41, k=10) to 1.00 (0.46-1.53, k=10). There is increasing awareness among policy makers of the needs of PLWD for full participation in physical activity. Physical activity action plans worldwide must be adequately resourced, monitored, and enforced to truly advance the fundamental rights of PLWD to fully participate in physical activity.
C1 [Ginis, Kathleen A. Martin] Univ British Columbia, Fac Hlth & Social Dev, Sch Hlth & Exercise Sci, Dept Med,Fac Med, Kelowna, BC, Canada.
   [Ginis, Kathleen A. Martin] Univ British Columbia, Fac Hlth & Social Dev, Sch Hlth & Exercise Sci, Ctr Chron Dis Prevent & Management,Fac Med, Kelowna, BC, Canada.
   [Ginis, Kathleen A. Martin] Univ British Columbia, Fac Hlth & Social Dev, Sch Hlth & Exercise Sci, Int Collaborat Repair Discoveries,Fac Med, Kelowna, BC, Canada.
   [Ginis, Kathleen A. Martin] Univ British Columbia, Reichwald Hlth Sci Ctr, Kelowna, BC, Canada.
   [van der Ploeg, Hidde P.] Vrije Univ Amsterdam, Amsterdam UMC, Dept Publ & Occupat Hlth, Amsterdam, Netherlands.
   [van der Ploeg, Hidde P.] Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands.
   [van der Ploeg, Hidde P.] Univ Sydney, Sydney Sch Publ Hlth, Sydney, NSW, Australia.
   [Foster, Charlie] Univ Bristol, Sch Policy Studies, Ctr Exercise Nutr & Hlth Sci, Bristol, Avon, England.
   [Lai, Byron] Univ Alabama Birmingham, Sch Med, Div Pediat Rehabil Med, Birmingham, AL USA.
   [McBride, Christopher B.] Spinal Cord Injury British Columbia, Vancouver, BC, Canada.
   [Ng, Kwok] Univ Eastern Finland, Sch Educ Sci & Psychol, Joensuu, Finland.
   [Ng, Kwok] Univ Limerick, Dept Phys Educ & Sport Sci, Limerick, Ireland.
   [Smith, Brett] Univ Durham, Sch Sport & Exercise Sci, Durham, England.
   [Pratt, Michael] Univ Calif San Diego, Inst Publ Hlth, San Diego, CA 92103 USA.
   [Pratt, Michael] Univ Calif San Diego, Herbert Wertheim Sch Publ Hlth & Human Longev Sci, San Diego, CA 92103 USA.
   [Vasquez, Priscilla M.] Univ Calif San Diego, Dept Family Med & Publ Hlth, San Diego, CA 92103 USA.
   [Shirazipour, Celina H.] Cedars Sinai Med Ctr, Res Ctr Hlth Equ, Los Angeles, CA 90048 USA.
   [Shirazipour, Celina H.] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA.
   [Heath, Gregory W.] Univ Tennessee, Dept Hlth & Human Performance, Chattanooga, TN USA.
C3 University of British Columbia; University of British Columbia;
   University of British Columbia; University of British Columbia; Vrije
   Universiteit Amsterdam; University of Amsterdam; University of
   Amsterdam; Vrije Universiteit Amsterdam; University of Sydney;
   University of Bristol; University of Alabama System; University of
   Alabama Birmingham; University of Eastern Finland; University of
   Limerick; Durham University; Public Health Institute; University of
   California System; University of California San Diego; University of
   California System; University of California San Diego; University of
   California System; University of California San Diego; Cedars Sinai
   Medical Center; University of California System; University of
   California Los Angeles; University of Tennessee System; University of
   Tennessee at Chattanooga
RP Ginis, KAM (corresponding author), Univ British Columbia, Fac Med, Kelowna, BC V1V 1V7, Canada.
EM kathleen_martin.ginis@ubc.ca
RI MARTIN GINIS, KATHLEEN/KFS-1807-2024; van der Ploeg,
   Hidde/ABD-6402-2021; Ng, Kwok/K-6648-2013
OI MARTIN GINIS, KATHLEEN/0000-0002-7076-3594; Smith,
   Brett/0000-0001-7137-2889; Ng, Kwok/0000-0002-5461-7706; van der Ploeg,
   Hidde/0000-0002-3719-5249
FU US National Institutes of Health [NIH 3R15GM131315-01A1S1]
FX We gratefully acknowledge research and administrative support from
   Gabriel Dix, Sarah Lawrason, Zachary North, Ritu Sharma, and Adrienne
   Sinden. KAMG holds the Reichwald Family Southern Medical Program Chair
   in Preventive Medicine. GWH is in receipt of a US National Institutes of
   Health grant that is unrelated to this manuscript (NIH
   3R15GM131315-01A1S1).
CR [Anonymous], 2019, LANCET, V394, P187, DOI 10.1016/S0140-6736(19)31638-1
   [Anonymous], 2007, UN DESA PUBL
   [Anonymous], 2014, World-wide survey of school physical education: final report - UNESCO Digital Library
   [Anonymous], 2001, ICF INT CLASFUNCT
   Arbour KP, 2007, ADAPT PHYS ACT Q, V24, P144, DOI 10.1123/apaq.24.2.144
   Bania T, 2011, CLIN REHABIL, V25, P303, DOI 10.1177/0269215510383062
   Barg CJ, 2010, INT J DISABIL DEV ED, V57, P371, DOI 10.1080/1034912X.2010.524417
   Barnes C., 1991, Disabled People in Britain and Discrimination
   Blauwet C, 2012, PM&R, V4, P851, DOI 10.1016/j.pmrj.2012.08.015
   Bodde AE, 2009, DISABIL HEALTH J, V2, P57, DOI 10.1016/j.dhjo.2008.11.004
   Bornstein MH, 2013, SOC SCI MED, V97, P307, DOI 10.1016/j.socscimed.2012.09.049
   Bossink LWM, 2017, RES DEV DISABIL, V68, P95, DOI 10.1016/j.ridd.2017.06.008
   Bright T, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15102165
   Brittain I, 2014, STOKE MANDEVILLE SOC
   Brown C, 2018, J SPORT SOC ISSUES, V42, P343, DOI 10.1177/0193723518781237
   Brown David R, 2014, Qual Life Res, V23, P2673, DOI 10.1007/s11136-014-0739-z
   Bull FC, 2020, BRIT J SPORT MED, V54, P1451, DOI 10.1136/bjsports-2020-102955
   Carroll DD, 2014, MMWR-MORBID MORTAL W, V63, P407
   Carty C, 2021, J PHYS ACT HEALTH, V18, P350, DOI 10.1123/jpah.2021-0137
   Carty C, 2021, J PHYS ACT HEALTH, V18, P86, DOI 10.1123/jpah.2020-0629
   Casey B, 2018, ARCH PHYS MED REHAB, V99, P2059, DOI 10.1016/j.apmr.2017.12.013
   Charlton J., 1998, Nothing About Us Without Us-Disability Oppression and Empowerment, P3, DOI DOI 10.1525/CALIFORNIA/9780520207950.001.0001
   Clément-Guillotin C, 2018, PSYCHOL SPORT EXERC, V38, P192, DOI 10.1016/j.psychsport.2018.06.014
   Copeland J.L., 2019, Kinesiology Review, V8, P70
   Dairo Yetunde Marion, 2016, Prev Med Rep, V4, P209, DOI 10.1016/j.pmedr.2016.06.008
   de Hollander Ellen L, 2018, Prev Med Rep, V10, P370, DOI 10.1016/j.pmedr.2018.04.017
   Dennett R, 2018, PHYS THER, V98, P679, DOI 10.1093/ptj/pzy060
   Ding D, 2020, BRIT J SPORT MED, V54, P462, DOI 10.1136/bjsports-2019-101001
   Ding D, 2016, LANCET, V388, P1311, DOI 10.1016/S0140-6736(16)30383-X
   Ellis K., 2009, ASIAN PACIFIC MEDIA, V19, P23
   Evans MB, 2018, PSYCHOL SPORT EXERC, V37, P79, DOI 10.1016/j.psychsport.2018.04.009
   Gainforth HL, 2021, ARCH PHYS MED REHAB, V102, P656, DOI 10.1016/j.apmr.2020.09.393
   Gainforth HL, 2013, INT J SPORT EXERC PS, V11, P244, DOI 10.1080/1612197X.2013.749001
   Ginis KAM, 2018, SPINAL CORD, V56, P308, DOI 10.1038/s41393-017-0017-3
   Ginis KAM, 2017, ARCH PHYS MED REHAB, V98, P395, DOI 10.1016/j.apmr.2016.04.017
   Ginis KAM, 2016, HEALTH PSYCHOL REV, V10, P478, DOI 10.1080/17437199.2016.1198240
   Goodley D, 2014, SUBJECTIVITY, V7, P342, DOI 10.1057/sub.2014.15
   Guthold R, 2020, LANCET CHILD ADOLESC, V4, P23, DOI 10.1016/S2352-4642(19)30323-2
   Haegele JA, 2015, ADAPT PHYS ACT Q, V32, P68, DOI 10.1123/apaq.2013-0110
   Hallal PC, 2012, LANCET, V380, P247, DOI 10.1016/S0140-6736(12)60646-1
   Heath Gregory W, 2006, J Phys Act Health, V3, pS55, DOI 10.1123/jpah.3.s1.s55
   Hodges C. E. M., 2014, Tracking changes in everyday experiences of disability and disability sport within the context of the 2012 London Paralympics
   Hoekstra F, 2021, DISABIL REHABIL, V43, P1710, DOI 10.1080/09638288.2019.1675188
   Hoekstra F, 2019, DISABIL REHABIL, V41, P1217, DOI 10.1080/09638288.2017.1423402
   Hutzler Y, 2010, J INTELL DISABIL RES, V54, P767, DOI 10.1111/j.1365-2788.2010.01313.x
   Iemmi V, 2017, COCHRANE DB SYST REV, V3
   Iezzoni LI, 2013, MED CARE, V51, P133, DOI 10.1097/MLR.0b013e31827da9b9
   Jackson J, 2019, DISABIL HEALTH J, V12, P296, DOI 10.1016/j.dhjo.2018.11.008
   Jull J, 2017, IMPLEMENT SCI, V12, DOI 10.1186/s13012-017-0696-3
   Kittson K, 2013, PSYCHOL SPORT EXERC, V14, P847, DOI 10.1016/j.psychsport.2013.07.003
   Lankhorst K, 2020, ARCH PHYS MED REHAB, V101, P535, DOI 10.1016/j.apmr.2019.09.006
   Lonsdale C, 2013, PREV MED, V56, P152, DOI 10.1016/j.ypmed.2012.12.004
   Ma JK, 2018, PSYCHOL SPORT EXERC, V37, P262, DOI 10.1016/j.psychsport.2018.01.006
   Madans JH, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-S4-S4
   Martin Ginis KA., J PHYS ACT HEALTH, V18, P348
   Mauerberg-deCastro E, 2017, ROUT INT HANDB, P241
   McConachie H, 2006, DISABIL REHABIL, V28, P1157, DOI 10.1080/09638280500534507
   McGarty AM, 2018, J INTELL DISABIL RES, V62, P312, DOI 10.1111/jir.12467
   McGarty AM, 2018, RES DEV DISABIL, V73, P40, DOI 10.1016/j.ridd.2017.12.007
   McGillivray D, 2018, URBAN GEOGR, V39, P329, DOI 10.1080/02723638.2017.1328577
   McLaughlin H, 2010, BRIT J SOC WORK, V40, P1591, DOI 10.1093/bjsw/bcp064
   McPherson AC, 2014, DISABIL REHABIL, V36, P1573, DOI 10.3109/09638288.2013.863391
   Menezes D, 2017, DISABIL HEALTH J, V10, P33, DOI 10.1016/j.dhjo.2016.06.005
   Mitchell S., 2006, Removing barriers to survey participation for persons with disabilities
   Moss SJ, 2018, DISABIL REHABIL, V40, P360, DOI 10.1080/09638288.2016.1258092
   National Academies of Sciences Engineering and Medicine, 2017, PEOPL LIV DIS HLTH E
   Ng K, 2017, ADAPT PHYS ACT Q, V34, P456, DOI 10.1123/apaq.2016-0138
   Owens J, 2015, SOCIOL HEALTH ILL, V37, P385, DOI 10.1111/1467-9566.12199
   Peers D, 2009, DISABIL SOC, V24, P653, DOI 10.1080/09687590903011113
   Perrier MJ, 2017, PERSUASION COMMUNICA, P233
   Physical Activity Guidelines Advisory Committee, 2018, 2018 Physical Activity Guidelines Advisory Committee Scientific Report Internet
   Pratt M, 2015, PROG CARDIOVASC DIS, V57, P356, DOI 10.1016/j.pcad.2014.09.002
   Reedman S, 2017, DEV MED CHILD NEUROL, V59, P1011, DOI 10.1111/dmcn.13413
   Right to Play, 2008, Harnessing the Power of Sport for Development and Peace: Recommendations to Governments
   Rimmer JH, 2012, LANCET, V380, P193, DOI 10.1016/S0140-6736(12)61028-9
   Rosly MM, 2018, SPINAL CORD, V56, P806, DOI 10.1038/s41393-018-0068-0
   Sallis JF, 2016, LANCET, V388, P1325, DOI 10.1016/S0140-6736(16)30581-5
   Sangelaji B, 2016, CLIN REHABIL, V30, P559, DOI 10.1177/0269215515595274
   Sherrill C., 2004, Young people with disability in physical education/physical activity/sport in and out of schools: technical report for the World Health Organization
   Shikako-Thomas K, 2015, DISABIL SOC, V30, P381, DOI 10.1080/09687599.2015.1009001
   Shin IS, 2012, RES DEV DISABIL, V33, P1937, DOI 10.1016/j.ridd.2012.05.019
   Shirazipour CH, 2020, DISABIL REHABIL, V42, P147, DOI 10.1080/09638288.2018.1494215
   Silva CF, 2018, PHYS MED REH CLIN N, V29, P397, DOI 10.1016/j.pmr.2018.01.009
   Silva CF, 2012, J SPORT SOC ISSUES, V36, P174, DOI 10.1177/0193723511433865
   Smith B., 2018, The palgrave handbook of paralympic studies, P15, DOI [DOI 10.1057/978-1-137-47901-32, 10.1057/978-1-137-47901-3_2, DOI 10.1057/978-1-137-47901-3_2]
   Smith B, 2021, DISABIL REHABIL, V43, P3427, DOI 10.1080/09638288.2019.1679896
   Smith B, 2019, BRIT J SPORT MED, V53, P335, DOI 10.1136/bjsports-2018-100158
   Special Olympics World Winter Games Austria, 2017, ATHLETES
   Spengler JO., 2015, Physical Literacy: A Global Environmental Scan, DOI DOI 10.1016/j.jsams.2015.11.003
   Sport England, 2017, ACT LIV AD SURV
   Stretton CM, 2017, CLIN REHABIL, V31, P310, DOI 10.1177/0269215516640863
   Stubbs B, 2018, SCHIZOPHR RES, V193, P412, DOI 10.1016/j.schres.2017.06.025
   Thomas C., 2007, Sociologies of Disability and Illness: Contested Ideas in Disability Studies and Medical Sociology, DOI DOI 10.1007/978-1-137-02019-2
   Thomas C, 2012, SOC THEOR HEALTH, V10, P209, DOI 10.1057/sth.2012.7
   Tierney M, 2015, PHYSIOTHERAPY, V101, P193, DOI 10.1016/j.physio.2014.07.005
   Todd K.R., 2019, Kinesiology Review, V8, P54, DOI [10.1123/kr.2018-0062, DOI 10.1123/KR.2018-0062]
   Tomasone JR, 2014, IMPLEMENT SCI, V9, DOI 10.1186/1748-5908-9-30
   Tremblay MS, 2017, INT J BEHAV NUTR PHY, V14, DOI 10.1186/s12966-017-0525-8
   Tremblay MS, 2016, J PHYS ACT HEALTH, V13, pS343, DOI 10.1123/jpah.2016-0594
   Tyrrell AC, 2010, REHABIL PSYCHOL, V55, P383, DOI 10.1037/a0021539
   US Department of Health Human Services, 2018, PHYS ACT GUID AM, V2nd
   Vancampfort Davy, 2017, Int J Behav Nutr Phys Act, V14, P6, DOI 10.1186/s12966-017-0463-5
   Walmsley J., 2003, INCLUSIVE RES PEOPLE
   Warburton DER, 2017, CURR OPIN CARDIOL, V32, P541, DOI 10.1097/HCO.0000000000000437
   WHO, 2011, WORLD REPORT ON DISABILITY, P1
   WHO, 2010, SCREENING DONATED BLOOD FOR TRANSFUSION: TRANSMISSIBLE INFECTIONS, P1
   Williams TL, 2017, HEALTH PSYCHOL REV, V11, P179, DOI 10.1080/17437199.2017.1299027
   Wilson NC, 2013, DISABIL SOC, V28, P1132, DOI 10.1080/09687599.2012.758034
   Wilson PB, 2016, J PEDIATR-US, V176, P23, DOI 10.1016/j.jpeds.2016.06.016
   World Health Organization, 2019, World Health Organization
   Young R., 2016, DISABIL CBR INCL DEV, V27, P27
   Yousafzai AK, 2014, ARCH DIS CHILD, V99, P840, DOI 10.1136/archdischild-2012-302066
NR 112
TC 272
Z9 287
U1 19
U2 137
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0140-6736
EI 1474-547X
J9 LANCET
JI Lancet
PD JUL 31
PY 2021
VL 398
IS 10298
BP 443
EP 455
DI 10.1016/S0140-6736(21)01164-8
EA JUL 2021
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA TS1BS
UT WOS:000679392600026
PM 34302764
OA Green Published, Green Accepted, Bronze
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Siskind, D
   Bull, C
   Suetani, S
   Warren, N
   Suraev, A
   Mcgregor, I
   Kisely, S
   De Monte, V
   Trott, M
   Shine, M
   Moudgil, V
   Robinson, G
   Parker, S
   Krishnaiah, R
   Stedman, T
   Drummond, A
   Medland, S
   Iyer, R
   Baker, A
AF Siskind, Dan
   Bull, Claudia
   Suetani, Shuichi
   Warren, Nicola
   Suraev, Anastasia
   Mcgregor, Iain
   Kisely, Steve
   De Monte, Veronica
   Trott, Mike
   Shine, Manju
   Moudgil, Vikas
   Robinson, Gail
   Parker, Stephen
   Krishnaiah, Ravikumar
   Stedman, Terry
   Drummond, Allan
   Medland, Sarah
   Iyer, Ravi
   Baker, Andrea
TI Protocol for Cancloz: multicentre randomised, placebo-controlled,
   double-blind, parallel-group adaptive trial of cannabidiol for
   clozapine-resistant schizophrenia
SO BJPSYCH OPEN
LA English
DT Article
DE Schizophrenia; cannabidiol; clozapine; treatment-resistant
   schizophrenia; randomised controlled trial
ID GUIDELINES; COGNITION; SCALE
AB Background Although clozapine is the most effective antipsychotic for people with treatment-resistant schizophrenia (TRS), only 40% of people with TRS respond, and there is limited evidence for augmentation agents. Cannabidiol (CBD) reduces positive symptoms in individuals with schizophrenia, but no trials have specifically examined its efficacy in those with clozapine-resistant schizophrenia. Aims To examine the clinical efficacy of CBD augmentation in people with clozapine-resistant schizophrenia. Method This is a 12-week randomised, placebo-controlled, double-blind, parallel-group trial (registration number: ACTRN12622001112752). We will recruit 88 individuals with clozapine-resistant schizophrenia, randomised (1:1) to 1000 mg daily CBD versus placebo. Eligible individuals will be aged between 18 and 64 years, fulfil DSM-IV criteria for schizophrenia or schizoaffective disorder, have a total PANSS (Positive and Negative Syndrome Scale) score >= 60, have received oral clozapine for at least 18 weeks and have a clozapine level of >350 ng/mL. Interim analyses will be conducted at 25, 50 and 75% recruitment; these will also provide an opportunity to reallocate participants dependent on conditional power. The primary endpoint will be the difference in PANSS positive scores at the end of week 12. Secondary endpoints include depression, anxiety, sleep, quality of life, alcohol consumption, change in weight and metabolic syndrome components, and neurocognitive measures, as well as safety and tolerability. Discussion Novel treatments for clozapine-resistant schizophrenia are urgently needed. If found to be effective, CBD may have a role as a novel and safe adjunct to clozapine.
C1 [Siskind, Dan; Bull, Claudia; Warren, Nicola; Kisely, Steve; Trott, Mike; Parker, Stephen] Univ Queensland, Fac Med, Woolloongabba, Australia.
   [Siskind, Dan; Warren, Nicola; Kisely, Steve; De Monte, Veronica; Shine, Manju] Metro South Addict & Mental Hlth Serv, Woolloongabba, Australia.
   [Siskind, Dan; Bull, Claudia; Suetani, Shuichi; Warren, Nicola; Trott, Mike; Baker, Andrea] Queensland Ctr Mental Hlth Res, Wacol, Australia.
   [Siskind, Dan; Suetani, Shuichi] Univ Queensland, Queensland Brain Inst, Brisbane, Australia.
   [Suetani, Shuichi] Inst Urban Indigenous Hlth, Windsor, Australia.
   [Suetani, Shuichi; Parker, Stephen] Griffith Univ, Sch Med & Dent, Southport, Australia.
   [Suraev, Anastasia; Mcgregor, Iain] Univ Sydney, Lambert Initiat Cannabinoid Therapeut, Sydney, Australia.
   [Moudgil, Vikas; Parker, Stephen] Royal Brisbane Womens Hosp, Metro North Mental Hlth, Herston, Australia.
   [Robinson, Gail] Prince Charles Hosp, Metro North Mental Hlth, Chermside, Australia.
   [Krishnaiah, Ravikumar] Gold Coast Univ Hosp, Community Mental Hlth, Southport, Australia.
   [Stedman, Terry] West Moreton Div Mental Hlth & Specialised Serv, Wacol, Australia.
   [Drummond, Allan] Goodna Community Mental Hlth, Goodna, Australia.
   [Drummond, Allan] Integrated Mental Hlth Ctr, Ipswich, Australia.
   [Medland, Sarah] QIMR Berghofer Med Res Inst, Herston, Australia.
   [Iyer, Ravi] MAGNET Mental Hlth Australia Gen Clin Trials Netwo, Geelong, Australia.
   [Iyer, Ravi] Swinburne Univ Technol, Hawthorn, Australia.
C3 University of Queensland; Queensland Centre for Mental Health Research;
   University of Queensland; Griffith University; Griffith University -
   Gold Coast Campus; University of Sydney; Royal Brisbane & Women's
   Hospital; Prince Charles Hospital; Gold Coast University Hospital; QIMR
   Berghofer Medical Research Institute; Swinburne University of Technology
RP Siskind, D (corresponding author), Univ Queensland, Fac Med, Woolloongabba, Australia.; Siskind, D (corresponding author), Metro South Addict & Mental Hlth Serv, Woolloongabba, Australia.; Siskind, D (corresponding author), Queensland Ctr Mental Hlth Res, Wacol, Australia.; Siskind, D (corresponding author), Univ Queensland, Queensland Brain Inst, Brisbane, Australia.
EM d.siskind@uq.edu.au
RI Medland, Sarah/HRD-4930-2023; Parler, Stephen/D-7830-2013; McGregor,
   Iain/E-4463-2014; Robinson, Gail/C-2978-2011; Suraev,
   Anastasia/AAJ-3524-2021; Bull, Claudia/JRW-5850-2023; Warren,
   Nicola/O-8355-2018; Kisely, Steve/B-4680-2012; Trott, Mike/GWR-1913-2022
OI Warren, Nicola/0000-0002-0805-1182; Bull, Claudia/0000-0003-4064-652X;
   Kisely, Steve/0000-0003-4021-2924; Trott, Mike/0000-0001-5978-3407;
   Suetani, Shuichi/0000-0002-2487-5691
FU Princess Alexandra Hospital Foundation [RSS_2021_020]; Lambert
   Initiative for Cannabinoid Therapeutics at the University of Sydney
FX This work was supported by the Princess Alexandra Hospital Foundation
   (D.S. (RSS_2021_020)) and the Lambert Initiative for Cannabinoid
   Therapeutics at the University of Sydney. The manufacturer of the CBD is
   not involved in the design of the study. The CBD and placebo were
   supplied for this trial by the Lambert Initiative for Cannabinoid
   Therapeutics at the University of Sydney.
CR ADDINGTON D, 1990, SCHIZOPHR RES, V3, P247, DOI 10.1016/0920-9964(90)90005-R
   Blessing EM, 2015, NEUROTHERAPEUTICS, V12, P825, DOI 10.1007/s13311-015-0387-1
   Boggs DL, 2018, PSYCHOPHARMACOLOGY, V235, P1923, DOI 10.1007/s00213-018-4885-9
   Busner Joan, 2007, Psychiatry (Edgmont), V4, P28
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1016/0165-1781(89)90047-4
   Castle DJ, 2006, PSYCHOL MED, V36, P69, DOI 10.1017/S0033291705005969
   Deiana S, 2013, DRUG TEST ANAL, V5, P46, DOI 10.1002/dta.1425
   Fasinu PS, 2016, PHARMACOTHERAPY, V36, P781, DOI 10.1002/phar.1780
   GAUDINO EA, 1995, J CLIN EXP NEUROPSYC, V17, P529, DOI 10.1080/01688639508405143
   HALL RCW, 1995, PSYCHOSOMATICS, V36, P267, DOI 10.1016/S0033-3182(95)71666-8
   HAMILTON M, 1959, BRIT J MED PSYCHOL, V32, P50, DOI 10.1111/j.2044-8341.1959.tb00467.x
   Holdnack J. A., 2009, ADV CLIN SOLUTIONS U
   Howes OD, 2017, AM J PSYCHIAT, V174, P216, DOI 10.1176/appi.ajp.2016.16050503
   Iffland K, 2017, CANNABIS CANNABINOID, V2, P139, DOI 10.1089/can.2016.0034
   KAY SR, 1987, SCHIZOPHRENIA BULL, V13, P261, DOI 10.1093/schbul/13.2.261
   Keefe RSE, 2008, SCHIZOPHR RES, V102, P108, DOI 10.1016/j.schres.2008.03.024
   Land R, 2017, ACTA PSYCHIAT SCAND, V135, P296, DOI 10.1111/acps.12700
   Leweke FM, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.15
   Lieberman JA, 2005, NEW ENGL J MED, V353, P1209, DOI 10.1056/NEJMoa051688
   Lu HC, 2016, BIOL PSYCHIAT, V79, P516, DOI 10.1016/j.biopsych.2015.07.028
   McGuire P, 2018, AM J PSYCHIAT, V175, P225, DOI 10.1176/appi.ajp.2017.17030325
   Moher D, 2012, INT J SURG, V10, P28, DOI 10.1016/j.ijsu.2011.10.001
   O'Neill A, 2021, PSYCHOL MED, V51, P596, DOI 10.1017/S0033291719003519
   Pacher P, 2006, PHARMACOL REV, V58, P389, DOI 10.1124/pr.58.3.2
   Pisanti S, 2017, PHARMACOL THERAPEUT, V175, P133, DOI 10.1016/j.pharmthera.2017.02.041
   RABKIN JG, 1992, J CLIN PSYCHOPHARM, V12, P3
   Richardson J., 2009, Data used in the development of the AQoL-8D (PsyQoL) quality of life instrument
   Rosenbaum S, 2020, BMC PSYCHIATRY, V20, DOI 10.1186/s12888-020-2473-0
   Saha S, 2005, PLOS MED, V2, P413, DOI 10.1371/journal.pmed.0020141
   Sarris J, 2020, BMC PSYCHIATRY, V20, DOI 10.1186/s12888-019-2409-8
   SAUNDERS JB, 1993, ADDICTION, V88, P791, DOI 10.1111/j.1360-0443.1993.tb02093.x
   Siskind D, 2023, BJPSYCH OPEN, V9, DOI 10.1192/bjo.2023.532
   Siskind D, 2022, BRIT J PSYCHIAT, V220, P115, DOI 10.1192/bjp.2021.61
   Siskind D, 2021, THER ADV PSYCHOPHARM, V11, DOI 10.1177/20451253211045248
   Siskind D, 2017, CAN J PSYCHIAT, V62, P772, DOI 10.1177/0706743717718167
   Siskind D, 2016, BRIT J PSYCHIAT, V209, P387, DOI 10.1192/bjp.bp.115.177261
   Siskind DJ, 2018, AUST NZ J PSYCHIAT, V52, P751, DOI 10.1177/0004867418772351
   Siskind DJ, 2018, DIABETES OBES METAB, V20, P1050, DOI 10.1111/dom.13167
   Taylor L, 2018, CNS DRUGS, V32, P1053, DOI 10.1007/s40263-018-0578-5
   Vasudev K, 2017, CAN J PSYCHIAT, V62, P138, DOI 10.1177/0706743716670128
   Wang T, 2008, CAN MED ASSOC J, V178, P1669, DOI 10.1503/cmaj.071178
   White MA, 2002, OBES RES, V10, P107, DOI 10.1038/oby.2002.17
   World Med Assoc, 2013, JAMA-J AM MED ASSOC, V310, P2191, DOI 10.1001/jama.2013.281053
NR 43
TC 0
Z9 0
U1 0
U2 0
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2056-4724
J9 BJPSYCH OPEN
JI BJPsych Open
PD OCT 3
PY 2024
VL 10
IS 5
AR e156
DI 10.1192/bjo.2024.748
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA I0E1U
UT WOS:001327067000001
PM 39359160
OA gold
DA 2025-06-11
ER

PT J
AU Chistiakov, DA
   Orekhov, AN
   Bobryshev, YV
AF Chistiakov, Dimitry A.
   Orekhov, Alexander N.
   Bobryshev, Yuri V.
TI Endothelial Barrier and Its Abnormalities in Cardiovascular Disease
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE endothelium; endothelial barrier; cell-to-cell junctions; endothelial
   intercellular junctions; cardiovascular disease
AB Endothelial cells (ECs) form a unique barrier between the vascular lumen and the vascular wall. In addition, the endothelium is highly metabolically active. In cardiovascular disease such as atherosclerosis and hypertension, normal endothelial function could be severely disturbed leading to endothelial dysfunction that then could progress to complete and irreversible loss of EC functionality and contribute to entire vascular dysfunction. Proatherogenic stimuli such as diabetes, dyslipidemia, and oxidative stress could initiate endothelial dysfunction and in turn vascular dysfunction and lead to the development of atherosclerotic arterial disease, a background for multiple cardiovascular disorders including coronary artery disease, acute coronary syndrome, stroke, and thrombosis. Intercellular junctions between ECs mediate the barrier function. Proinflammatory stimuli destabilize the junctions causing the disruption of the endothelial barrier and increased junctional permeability. This facilitates transendothelial migration of immune cells to the arterial intima and induction of vascular inflammation. Proatherogenic stimuli attack endothelial microtubule function that is regulated by acetylation of tubulin, an essential microtubular constituent. Chemical modification of tubulin caused by cardiometabolic risk factors and oxidative stress leads to reorganization of endothelial microtubules. These changes destabilize vascular integrity and increase permeability, which finally results in increasing cardiovascular risk.
C1 [Chistiakov, Dimitry A.] Res Ctr Childrens Hlth, Inst Pediat, Dept Mol Genet Diagnost & Cell Biol, Div Lab Med, Moscow, Russia.
   [Orekhov, Alexander N.] Russian Acad Sci, Inst Gen Pathol & Pathophysiol, Lab Angiopathol, Moscow, Russia.
   [Orekhov, Alexander N.] Moscow MV Lomonosov State Univ, Biol Fac, Dept Biophys, Moscow, Russia.
   [Orekhov, Alexander N.] Skolkovo Innovat Ctr, Inst Atherosclerosis Res, Moscow, Russia.
   [Bobryshev, Yuri V.] Univ New South Wales, Sch Med Sci, Fac Med, Sydney, NSW, Australia.
   [Bobryshev, Yuri V.] Univ Western Sydney, Sch Med, Campbelltown, NSW, Australia.
C3 Russian Academy of Medical Sciences; Institute of General Pathology &
   Pathophysiology, RAMS; Russian Academy of Sciences; Lomonosov Moscow
   State University; University of New South Wales Sydney; Western Sydney
   University
RP Bobryshev, YV (corresponding author), Univ New South Wales, Sch Med Sci, Fac Med, Sydney, NSW, Australia.; Bobryshev, YV (corresponding author), Univ Western Sydney, Sch Med, Campbelltown, NSW, Australia.
EM y.bobryshev@unsw.edu.au
RI Bobryshev, Yuri/J-2838-2013
FU Russian Scientific Foundation [14-15-00112]
FX This work was supported by a grant from the Russian Scientific
   Foundation (grant 14-15-00112).
CR Aird WC, 2007, CIRC RES, V100, P158, DOI 10.1161/01.RES.0000255691.76142.4a
   Amerongen GPV, 2000, CIRCULATION, V102, P2803
   [Anonymous], THESIS
   Asaka M, 2011, AM J PHYSIOL-CELL PH, V300, pC87, DOI 10.1152/ajpcell.00565.2010
   Azari BM, 2011, J TRANSL MED, V9, DOI 10.1186/1479-5876-9-98
   Babinska A, 2007, THROMB HAEMOSTASIS, V97, P272, DOI 10.1160/TH06-08-0454
   Bazzoni G, 2004, PHYSIOL REV, V84, P869, DOI 10.1152/physrev.00035.2003
   Behl T, 2015, PHARMACOL RES, V99, P137, DOI 10.1016/j.phrs.2015.05.013
   Bélanger M, 2007, NEUROCHEM INT, V50, P95, DOI 10.1016/j.neuint.2006.07.005
   Bradfield PF, 2007, ARTERIOSCL THROM VAS, V27, P2104, DOI 10.1161/ATVBAHA.107.147694
   Broermann A, 2011, J EXP MED, V208, P2393, DOI 10.1084/jem.20110525
   Broman MT, 2006, CIRC RES, V98, P73, DOI 10.1161/01.RES.0000198387.44395.e9
   Bush KT, 2000, AM J PHYSIOL-RENAL, V278, pF847, DOI 10.1152/ajprenal.2000.278.5.F847
   Chatterjee S, 2015, AM J PHYSIOL-HEART C, V308, pH1451, DOI 10.1152/ajpheart.00105.2015
   Chavez A, 2011, INT REV CEL MOL BIO, V290, P205, DOI 10.1016/B978-0-12-386037-8.00001-6
   Chervin-Pétinot A, 2012, J BIOL CHEM, V287, P7556, DOI 10.1074/jbc.M111.328682
   Chistiakov DA, 2015, MINI-REV MED CHEM, V15, P338, DOI 10.2174/1389557515666150226114031
   Colgan OC, 2007, AM J PHYSIOL-HEART C, V292, pH3190, DOI 10.1152/ajpheart.01177.2006
   Collins NT, 2006, ARTERIOSCL THROM VAS, V26, P62, DOI 10.1161/01.ATV.0000194097.92824.b3
   Conklin BS, 2007, WORLD J SURG, V31, P733, DOI 10.1007/s00268-006-0735-8
   Conklin BS, 2002, J SURG RES, V102, P13, DOI 10.1006/jsre.2001.6295
   Conway DE, 2013, CURR BIOL, V23, P1024, DOI 10.1016/j.cub.2013.04.049
   Cummins PM, 2012, MOL CELL BIOL, V32, P242, DOI 10.1128/MCB.06029-11
   Curry FRE, 2010, CARDIOVASC RES, V87, P218, DOI 10.1093/cvr/cvq115
   D'Souza-Schorey C, 2006, NAT REV MOL CELL BIO, V7, P347, DOI 10.1038/nrm1910
   Dan C, 2001, J BIOL CHEM, V276, P32115, DOI 10.1074/jbc.M100871200
   Davies PF, 1997, J VASC RES, V34, P208, DOI 10.1159/000159224
   Dejana E, 2013, J CELL SCI, V126, P2545, DOI 10.1242/jcs.124529
   Dejana E, 2009, DEV CELL, V16, P209, DOI 10.1016/j.devcel.2009.01.004
   Demaio L, 2001, AM J PHYSIOL-HEART C, V281, pH105, DOI 10.1152/ajpheart.2001.281.1.H105
   Dossumbekova A, 2008, AM J PHYSIOL-HEART C, V295, pH2417, DOI 10.1152/ajpheart.00501.2008
   Dyer LA, 2010, SEMIN THROMB HEMOST, V36, P227, DOI 10.1055/s-0030-1253446
   Ebnet K, 2008, HISTOCHEM CELL BIOL, V130, P1, DOI 10.1007/s00418-008-0418-7
   Feldman GJ, 2005, ADV DRUG DELIVER REV, V57, P883, DOI 10.1016/j.addr.2005.01.009
   Furuse M, 1998, J CELL BIOL, V141, P1539, DOI 10.1083/jcb.141.7.1539
   Garrido-Urbani S, 2014, CELL TISSUE RES, V355, P701, DOI 10.1007/s00441-014-1820-1
   Gatti CD, 2008, CLIN EXP HYPERTENS, V30, P616, DOI 10.1080/10641960802443183
   Gavard Julie, 2014, Cell Adh Migr, V8, P158
   Giannotta M, 2013, DEV CELL, V26, P441, DOI 10.1016/j.devcel.2013.08.020
   Goel Reema, 2008, Arterioscler Thromb Vasc Biol, V28, P1996, DOI 10.1161/ATVBAHA.108.172270
   Gomez GA, 2015, MOL BIOL CELL, V26, P1249, DOI 10.1091/mbc.E14-07-1223
   Gündüz D, 2010, ARTERIOSCL THROM VAS, V30, P1237, DOI 10.1161/ATVBAHA.110.203901
   Gulino-Debrac D, 2013, TISSUE BARRIERS, V1, DOI 10.4161/tisb.24180
   Hahn C, 2009, NAT REV MOL CELL BIO, V10, P53, DOI 10.1038/nrm2596
   Harrison M, 2013, ARTERIOSCL THROM VAS, V33, P694, DOI 10.1161/ATVBAHA.112.300379
   Harry BL, 2008, ARTERIOSCL THROM VAS, V28, P2003, DOI 10.1161/ATVBAHA.108.164707
   Hashimoto-Komatsu A, 2011, HYPERTENS RES, V34, P949, DOI 10.1038/hr.2011.64
   Hirase T, 2001, J BIOL CHEM, V276, P10423, DOI 10.1074/jbc.M007136200
   Hirase T, 2012, AM J PHYSIOL-HEART C, V302, pH499, DOI 10.1152/ajpheart.00325.2011
   Huveneers S, 2015, CIRC RES, V116, P895, DOI 10.1161/CIRCRESAHA.116.305720
   Ishiyama N, 2013, J BIOL CHEM, V288, P15913, DOI 10.1074/jbc.M113.453928
   Jaalouk DE, 2009, NAT REV MOL CELL BIO, V10, P63, DOI 10.1038/nrm2597
   Janssen MEW, 2006, MOL CELL, V21, P271, DOI 10.1016/j.molcel.2005.11.020
   Kevil CG, 2000, AM J PHYSIOL-CELL PH, V279, pC21, DOI 10.1152/ajpcell.2000.279.1.C21
   Kiuchi-Saishin Y, 2002, J AM SOC NEPHROL, V13, DOI 10.1681/ASN.V134875
   Köhler K, 2004, J CELL BIOL, V165, P175, DOI 10.1083/jcb.200312118
   Kuroda S, 1999, BIOCHEM BIOPH RES CO, V262, P1, DOI 10.1006/bbrc.1999.1122
   Lee TYJ, 2003, MICROSC RES TECHNIQ, V60, P115, DOI 10.1002/jemt.10250
   Li YH, 2005, J MOL BIOL, V352, P151, DOI 10.1016/j.jmb.2005.07.017
   LIM SS, 1989, J CELL BIOL, V109, P253, DOI 10.1083/jcb.109.1.253
   Lui WY, 2005, J CELL PHYSIOL, V203, P564, DOI 10.1002/jcp.20254
   Maiden SL, 2011, J CELL BIOL, V195, P543, DOI 10.1083/jcb.201103106
   Mandel I, 2012, J CELL BIOCHEM, V113, P2415, DOI 10.1002/jcb.24118
   Martìn-Padura I, 1998, J CELL BIOL, V142, P117, DOI 10.1083/jcb.142.1.117
   Maul RS, 2003, J CELL BIOL, V160, P399, DOI 10.1083/jcb.200212057
   McLachlan RW, 2007, MOL BIOL CELL, V18, P3214, DOI 10.1091/mbc.E06-12-1154
   McLachlan RW, 2007, J MOL MED-JMM, V85, P545, DOI 10.1007/s00109-007-0198-x
   McLachlan RW, 2011, CYTOSKELETON, V68, P32, DOI 10.1002/cm.20492
   Mehta D, 2014, AM J PHYSIOL-LUNG C, V307, pL924, DOI 10.1152/ajplung.00318.2014
   Minami T, 2005, TRENDS CARDIOVAS MED, V15, P174, DOI 10.1016/j.tcm.2005.06.002
   MITCHISON T, 1984, NATURE, V312, P237, DOI 10.1038/312237a0
   Morimoto S, 2005, J BIOL CHEM, V280, P2220, DOI 10.1074/jbc.M406906200
   Morita K, 1999, J CELL BIOL, V147, P185, DOI 10.1083/jcb.147.1.185
   Morita K, 1999, P NATL ACAD SCI USA, V96, P511, DOI 10.1073/pnas.96.2.511
   Murakami T, 2009, J BIOL CHEM, V284, P21036, DOI 10.1074/jbc.M109.016766
   Nawroth R, 2002, EMBO J, V21, P4885, DOI 10.1093/emboj/cdf497
   Nitta T, 2003, J CELL BIOL, V161, P653, DOI 10.1083/jcb.200302070
   Nottebaum AF, 2008, J EXP MED, V205, P2929, DOI 10.1084/jem.20080406
   Ozaki M, 2002, AM J PATHOL, V160, P1335, DOI 10.1016/S0002-9440(10)62560-6
   Padovani D, 2014, P NATL ACAD SCI USA, V111, P12378, DOI 10.1073/pnas.1409832111
   Pandithage R, 2008, J CELL BIOL, V180, P915, DOI 10.1083/jcb.200707126
   Pang JH, 2005, J BIOL CHEM, V280, P3043, DOI 10.1074/jbc.M412148200
   Pang ZY, 2005, ANN BIOMED ENG, V33, P1536, DOI 10.1007/s10439-005-7786-0
   Pries A. R., 2006, V176, P1
   Rabiet MJP, 1996, ARTERIOSCL THROM VAS, V16, P488, DOI 10.1161/01.ATV.16.3.488
   REPIN VS, 1984, ATHEROSCLEROSIS, V50, P35, DOI 10.1016/0021-9150(84)90006-6
   Runkle EA, 2013, CANCER LETT, V337, P41, DOI 10.1016/j.canlet.2013.05.038
   Sakagami H, 2008, TOHOKU J EXP MED, V214, P191, DOI 10.1620/tjem.214.191
   Scbmieder RE, 2007, CURR HYPERTENS REP, V9, P415, DOI 10.1007/s11906-007-0076-5
   Schmieder RE, 2007, LANCET, V369, P1208, DOI 10.1016/S0140-6736(07)60242-6
   Schulte D, 2011, EMBO J, V30, P4157, DOI 10.1038/emboj.2011.304
   Schulz B, 2008, CIRC RES, V102, P1192, DOI 10.1161/CIRCRESAHA.107.169805
   Shapiro L, 2009, CSH PERSPECT BIOL, V1, DOI 10.1101/cshperspect.a003053
   Shewan AM, 2005, MOL BIOL CELL, V16, P4531, DOI 10.1091/mbc.E05-04-0330
   Singleton PA, 2005, FASEB J, V19, P1646, DOI 10.1096/fj.05-3928com
   Sukriti S, 2014, PULM CIRC, V4, P535, DOI 10.1086/677356
   Sun CX, 2012, ARTERIOSCL THROM VAS, V32, P2444, DOI 10.1161/ATVBAHA.112.252205
   Sun CX, 2010, CARDIOVASC RES, V87, P348, DOI 10.1093/cvr/cvq060
   Takahashi S, 2009, J CELL SCI, V122, P985, DOI 10.1242/jcs.040055
   Ting LH, 2012, AM J PHYSIOL-HEART C, V302, pH2220, DOI 10.1152/ajpheart.00975.2011
   Tran ADA, 2007, J CELL SCI, V120, P1469, DOI 10.1242/jcs.03431
   Traweger A, 2002, J BIOL CHEM, V277, P10201, DOI 10.1074/jbc.M111384200
   Tse D, 2010, SEMIN THROMB HEMOST, V36, P236, DOI 10.1055/s-0030-1253447
   Tsukita S, 2001, NAT REV MOL CELL BIO, V2, P285, DOI 10.1038/35067088
   Tzima E, 2006, CIRC RES, V98, P176, DOI 10.1161/01.RES.0000200162.94463.d7
   Tzima E, 2005, NATURE, V437, P426, DOI 10.1038/nature03952
   VAN MEER G, 1986, NATURE, V322, P639, DOI 10.1038/322639a0
   Vestweber D, 2014, SEMIN IMMUNOPATHOL, V36, P177, DOI 10.1007/s00281-014-0419-7
   Vestweber D, 2012, ANN NY ACAD SCI, V1257, P184, DOI 10.1111/j.1749-6632.2012.06558.x
   Walsh TG, 2011, J CELL PHYSIOL, V226, P3053, DOI 10.1002/jcp.22655
   WEBER E, 1994, J CELL BIOL, V125, P583, DOI 10.1083/jcb.125.3.583
   WEIBEL ER, 1964, J CELL BIOL, V23, P101, DOI 10.1083/jcb.23.1.101
   Witt KA, 2003, AM J PHYSIOL-HEART C, V285, pH2820, DOI 10.1152/ajpheart.00589.2003
   Wójciak-Stothard B, 2001, J CELL SCI, V114, P1343
   Zernecke A, 2006, ARTERIOSCL THROM VAS, V26, pE10, DOI 10.1161/01.ATV.0000197852.24529.4f
   Zhang Y, 2003, EMBO J, V22, P1168, DOI 10.1093/emboj/cdg115
   Zheng Q, 2007, BIOL CELL, V99, P489, DOI 10.1042/BC20060126
   Ziegler WH, 2006, TRENDS CELL BIOL, V16, P453, DOI 10.1016/j.tcb.2006.07.004
NR 118
TC 182
Z9 204
U1 2
U2 16
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD DEC 9
PY 2015
VL 6
AR 365
DI 10.3389/fphys.2015.00365
PG 11
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA VF7OS
UT WOS:000443518100001
PM 26696899
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Herrero-Beaumont, G
   Castro-Dominguez, F
   Migliore, A
   Naredo, E
   Largo, R
   Reginster, JY
AF Herrero-Beaumont, Gabriel
   Castro-Dominguez, Francisco
   Migliore, Alberto
   Naredo, Esperanza
   Largo, Raquel
   Reginster, Jean-Yves
TI Systemic osteoarthritis: the difficulty of categorically naming a
   continuous condition
SO AGING CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Article
DE Osteoarthritis; Systemic; Chronic inflammation; Metabolic syndrome;
   Personalized treatment
ID KNEE OSTEOARTHRITIS; ADIPOSE-TISSUE; OBESITY; DISEASE
AB Osteoarthritis (OA) is a disease with systemic implications that go beyond joint problems. Its pathogenic mechanisms involve a variety of systemic conditions that contribute to joint damage. These include metabolic dysfunction, chronic low-grade inflammation, neuroplastic pain, and the influence of the central nervous system in the development of neuropathic pain. Besides, OA can negatively affect other aspects of health, such as quality of life, reduced physical activity, social isolation, depression, and anxiety. OA can be considered a complex system in which pathological interactions involve not only obesity and metabolic dysfunction, but also fragility syndrome, sarcopenia, neurological complications, and systemic energy redistribution. Complex systems are composed of multiple interacting and dynamic parts and exhibit emergent properties that cannot be fully explained by examining their individual components. Chronic low-grade inflammation is characteristic of OA, occurring both in the affected joint, and systemically, mainly due to adipose tissue inflammation in obese patients. Obesity is a key factor in the progression of OA, so primary treatment should focus on its control, while maintaining muscle health. The chronic inflammation could lead to changes in energy distribution among the affected joint tissues. Therefore, OA should be approached as a systemic disease, considering individual patient factors, such as genetics, inflammatory response, and lifestyle. Medical care should be more holistic and personalized. Consideration of a name change, such as "systemic OA", could help to move away from the perception of a disease focused only on the joints.
C1 [Herrero-Beaumont, Gabriel; Naredo, Esperanza; Largo, Raquel] IIS Fdn Jimenez Diaz UAM, Rheumatol Dept, Bone & Joint Res Unit, Madrid, Spain.
   [Castro-Dominguez, Francisco] Teknon Med Ctr, Rheumatol Dept, Quironsalud Grp, Barcelona, Spain.
   [Migliore, Alberto] San Pietro Fatebenefratelli Hosp, Rheumatol Unit, Rome, Italy.
   [Reginster, Jean-Yves] Univ Liege, WHO Collaborating Ctr Epidemiol Musculoskeletal Hl, Div Publ Hlth Epidemiol & Hlth Econ, Liege, Belgium.
C3 Fundacion Jimenez Diaz; quironsalud Group; University of Liege
RP Herrero-Beaumont, G (corresponding author), IIS Fdn Jimenez Diaz UAM, Rheumatol Dept, Bone & Joint Res Unit, Madrid, Spain.
EM gherrero@fjd.es
RI Reginster, Jean-Yves/AGC-6097-2022; Largo, Raquel/B-2949-2009
OI Largo, Raquel/0000-0001-6525-2944; Herrero-Beaumont,
   Gabriel/0000-0002-3241-991X; Castro-Dominguez,
   Francisco/0000-0003-1238-4200
FU Instituto de Salud Carlos III [PI20/00349, PI22/00352]; European Union
FX This study was supported by research grants from the Instituto de Salud
   Carlos III (PI20/00349; PI22/00352), co-funded by the European Union.
CR Atukorala I, 2016, ANN RHEUM DIS, V75, P390, DOI 10.1136/annrheumdis-2014-205894
   Aubourg G, 2022, OSTEOARTHR CARTILAGE, V30, P636, DOI 10.1016/j.joca.2021.03.002
   Batushansky A, 2022, OSTEOARTHR CARTILAGE, V30, P501, DOI 10.1016/j.joca.2021.06.013
   Berenbaum F, 2017, ARTHRITIS RHEUMATOL, V69, P9, DOI 10.1002/art.39842
   Bierma-Zeinstra SM, 2017, NAT REV RHEUMATOL, V13, P705, DOI 10.1038/nrrheum.2017.181
   Castañeda S, 2014, RHEUMATOLOGY, V53, P1, DOI 10.1093/rheumatology/ket247
   Cilliers P, 1999, S AFR J PHILOS, V18, P275, DOI 10.1080/02580136.1999.10878188
   Collins KH, 2021, P NATL ACAD SCI USA, V118, DOI 10.1073/pnas.2021096118
   Dell'Isola A, 2022, ARTHRIT CARE RES, V74, P1689, DOI 10.1002/acr.24717
   Fonseca-Rodrigues D, 2022, RHEUMATOLOGY, V61, P53, DOI 10.1093/rheumatology/keab512
   Fu K, 2018, RHEUMATOLOGY, V57, P43, DOI 10.1093/rheumatology/kex419
   Gratal P, 2020, FRONT MED-LAUSANNE, V7, DOI 10.3389/fmed.2020.00506
   Harasymowicz NS, 2017, ARTHRITIS RHEUMATOL, V69, P1396, DOI 10.1002/art.40102
   Herrero-Beaumont G, 2020, ANN RHEUM DIS, V79, P1261, DOI 10.1136/annrheumdis-2020-217454
   Herrero-Beaumont G, 2019, BIOCHEM PHARMACOL, V165, P24, DOI 10.1016/j.bcp.2019.02.030
   Largo R, 2012, OSTEOARTHR CARTILAGE, V20, pS126, DOI 10.1016/j.joca.2012.02.160
   Leyland KM, 2021, AGING CLIN EXP RES, V33, P529, DOI 10.1007/s40520-020-01762-2
   Li K, 2022, FASEB J, V36, DOI 10.1096/fj.202200485R
   Liu-Bryan R, 2015, NAT REV RHEUMATOL, V11, P35, DOI 10.1038/nrrheum.2014.162
   Long HB, 2023, AGING CLIN EXP RES, V35, P333, DOI 10.1007/s40520-022-02312-8
   Loughlin J, 2022, TRENDS MOL MED, V28, P176, DOI 10.1016/j.molmed.2021.12.007
   Mobasheri A, 2017, NAT REV RHEUMATOL, V13, P302, DOI 10.1038/nrrheum.2017.50
   Niu JB, 2017, ARTHRITIS RHEUMATOL, V69, P1194, DOI 10.1002/art.40087
   O'Neill TW, 2016, ANN RHEUM DIS, V75, P84, DOI 10.1136/annrheumdis-2014-206927
   Perruccio AV, 2023, ARTHRIT CARE RES, V75, P893, DOI 10.1002/acr.24826
   Roman-Blas JA, 2009, ARTHRITIS RES THER, V11, DOI 10.1186/ar2791
   Rosa SC, 2011, OSTEOARTHR CARTILAGE, V19, P719, DOI 10.1016/j.joca.2011.02.004
   Sanchez-Lopez E, 2022, NAT REV RHEUMATOL, V18, P258, DOI 10.1038/s41584-022-00749-9
   Stücker S, 2021, BEST PRACT RES CL RH, V35, DOI 10.1016/j.berh.2021.101722
   Tchetina EV, 2018, RHEUMATOL INT, V38, P1963, DOI 10.1007/s00296-018-4103-4
   Tchetina EV, 2016, INT J RHEUMATOL, V2016, DOI 10.1155/2016/6432867
   Thijssen E, 2015, RHEUMATOLOGY, V54, P588, DOI 10.1093/rheumatology/keu464
   Veronese N, 2018, J NUTR HEALTH AGING, V22, P371, DOI 10.1007/s12603-017-0941-0
   Veronese N, 2023, AGING CLIN EXP RES, V35, P245, DOI 10.1007/s40520-022-02289-4
NR 34
TC 8
Z9 8
U1 2
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1594-0667
EI 1720-8319
J9 AGING CLIN EXP RES
JI Aging Clin. Exp. Res.
PD FEB 20
PY 2024
VL 36
IS 1
AR 45
DI 10.1007/s40520-024-02714-w
PG 5
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA IV0R0
UT WOS:001168998800001
PM 38376694
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Thakur, B
   Alvarado, L
   Dodoo, C
   Salazar, R
   Espay, AJ
   Dwivedi, AK
AF Thakur, Bhaskar
   Alvarado, Luis
   Dodoo, Christopher
   Salazar, Ricardo
   Espay, Alberto J.
   Dwivedi, Alok Kumar
TI Ethnic Differences Between Hispanics and Non-Hispanic Whites in
   Neuropsychiatric Symptoms Predict Conversion to Mild Cognitive
   Impairment
SO JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
LA English
DT Article
DE neuropsychiatric symptoms; mild cognitive impairment; variable cluster
   analysis; psychomotor apathy; affective mood; physical behavior
ID ALZHEIMERS-DISEASE; MEXICAN-AMERICANS; BEHAVIORAL SYMPTOMS; METABOLIC
   SYNDROME; RISK-FACTORS; DEMENTIA; POPULATION; PREVALENCE; DIAGNOSIS;
   MANIFESTATIONS
AB The aim of the study is to ascertain the neuropsychiatric symptoms (NPS) subtypes significantly influencing progression to mild cognitive impairment (MCI) by ethnicity. In this retrospective cohort study, we included 386 cognitively normal individuals participating in the longitudinal Texas Alzheimer's Research and Care Consortium between February 2007 and August 2014. The primary outcome was time to incident MCI. Data driven NPS subtypes at baseline were identified and the effects of these subtypes on the outcome were obtained for Hispanic and non-Hispanic ethnic cohorts and summarized with a hazard ratio (HR). Three NPS subtypes were identified and internally validated: psychomotor apathy factor (including agitation, irritability, apathy), affective mood factor (including depression, anxiety), and physical behavior factor (including nighttime behavior, eating/appetite disturbances). In adjusted analysis, a psychomotor apathy score of NPS was the best predictor for MCI (HR = 2.19, p = 0.037) among non-Hispanics whereas physical behavior score was the most predictive of MCI (HR = 2.55, p = 0.029) among Hispanics. A high score of affective mood factor also tended to increase the risk of MCI (HR = 2.09, p = 0.06) in Hispanics. Progression from normal cognition to MCI was differentially predicted by NPS subtypes in Hispanics and non-Hispanic whites. These data may inform the allocation of efforts for monitoring individuals at-risk of MCI.
C1 [Thakur, Bhaskar; Dwivedi, Alok Kumar] Texas Tech Univ, Hlth Sci Ctr El Paso, Div Biostat & Epidemiol, Dept Mol & Translat Med,Paul L Foster Sch Med, El Paso, TX USA.
   [Alvarado, Luis; Dodoo, Christopher; Dwivedi, Alok Kumar] Texas Tech Univ, Hlth Sci Ctr El Paso, Biostat & Epidemiol Consulting Lab, Paul L Foster Sch Med, El Paso, TX USA.
   [Dodoo, Christopher; Salazar, Ricardo] Texas Tech Univ, Paul L Foster Sch Med, Memory Disorder & Geriatr Neuropsychiat Clin, Div Geriatr Psychiat,Dept Psychiat,Hlth Sci Ctr E, El Paso, TX USA.
   [Espay, Alberto J.] Univ Cincinnati, Dept Neurol & Rehabil Med, James J & Joan A Gardner Family Ctr Parkinsons Di, Cincinnati, OH 45221 USA.
C3 Texas Tech University System; Texas Tech University; Texas Tech
   University Health Sciences Center El Paso; Texas Tech University System;
   Texas Tech University; Texas Tech University Health Sciences Center El
   Paso; Texas Tech University System; Texas Tech University; University
   System of Ohio; University of Cincinnati
RP Dwivedi, AK (corresponding author), Texas Tech Univ, Hlth Sci Ctr El Paso TTUHSC EP, Paul L Foster Sch Med, Div Biostat & Epidemiol,Dept Mol & Translat Med, El Paso, TX 79905 USA.
EM alok.dwivedi@ttuhsc.edu
RI Dodoo, Christpher/AAE-9313-2019; Salazar, Ricardo/AAG-7883-2021; Espay,
   Alberto/AAC-4255-2020; Thakur, Bhaskar/AAE-9281-2019
OI Thakur, Bhaskar/0000-0001-6869-8968; Salazar,
   Ricardo/0000-0003-0608-2193; Dwivedi, Alok/0000-0003-4574-1761; Dodoo,
   Christopher/0000-0001-6269-1757
FU Darrell K Royal Texas Alzheimer's Initiative
FX The author(s) have not directly received any funding for this research
   study. However, this study was made possible by funding provided to the
   Texas Alzheimer's Research and Care Consortium by the Darrell K Royal
   Texas Alzheimer's Initiative, directed by the Texas Council on
   Alzheimer's Disease and Related Disorders.
CR Aalten P, 2007, DEMENT GERIATR COGN, V24, P457, DOI 10.1159/000110738
   Abner EL, 2017, ANN NEUROL, V81, P549, DOI 10.1002/ana.24903
   Apostolova LG, 2008, DEMENT GERIATR COGN, V25, P115, DOI 10.1159/000112509
   Babulal GM, 2017, J ALZHEIMERS DIS, V58, P675, DOI 10.3233/JAD-170067
   Banks SJ, 2014, DEMENT GER COGN D EX, V4, P509, DOI 10.1159/000357775
   Burhanullah MH, 2020, AM J GERIAT PSYCHIAT, V28, P64, DOI 10.1016/j.jagp.2019.03.023
   Burke Shanna L, 2019, Psychol Neurosci, V12, P144, DOI 10.1037/pne0000163
   Cerejeira J, 2012, Front Neurol, V3, P73, DOI 10.3389/fneur.2012.00073
   Chavent M, 2012, J STAT SOFTW, V50, P1
   Chen JC, 2000, AM J GERIAT PSYCHIAT, V8, P123, DOI 10.1176/appi.ajgp.8.2.123
   Clark CM, 2005, ARCH NEUROL-CHICAGO, V62, P774, DOI 10.1001/archneur.62.5.774
   Cohen CI, 1999, AM J GERIAT PSYCHIAT, V7, P57, DOI 10.1097/00019442-199924710-00008
   Creese B, 2019, AM J GERIAT PSYCHIAT, V27, P823, DOI 10.1016/j.jagp.2019.01.215
   Cummings JL, 1997, NEUROLOGY, V48, pS10, DOI 10.1212/WNL.48.5_Suppl_6.10S
   CUMMINGS JL, 1994, NEUROLOGY, V44, P2308, DOI 10.1212/WNL.44.12.2308
   Dechamps A, 2008, INT J GERIATR PSYCH, V23, P1182, DOI 10.1002/gps.2052
   Diniz BS, 2013, BRIT J PSYCHIAT, V202, P329, DOI 10.1192/bjp.bp.112.118307
   Donovan NJ, 2014, AM J GERIAT PSYCHIAT, V22, P1642, DOI 10.1016/j.jagp.2014.02.007
   Dwivedi AK, CANC REP
   Fernández-Martínez M, 2008, CURR ALZHEIMER RES, V5, P61, DOI 10.2174/156720508783884585
   Filshtein TJ, 2019, J ALZHEIMERS DIS, V68, P145, DOI 10.3233/JAD-180992
   Fitten LJ, 2014, INT J GERIATR PSYCH, V29, P586, DOI 10.1002/gps.4040
   Fitten LJ, 2001, J AM GERIATR SOC, V49, P1301, DOI 10.1046/j.1532-5415.2001.49257.x
   Forrester SN, 2016, AM J GERIAT PSYCHIAT, V24, P117, DOI 10.1016/j.jagp.2015.05.007
   Geda YE, 2008, ARCH GEN PSYCHIAT, V65, P1193, DOI 10.1001/archpsyc.65.10.1193
   Geda YE, 2014, AM J PSYCHIAT, V171, P572, DOI 10.1176/appi.ajp.2014.13060821
   Hargrave Rita, 2000, Journal of the National Medical Association, V92, P15
   He J, 2009, ARCH NEUROL-CHICAGO, V66, P1393, DOI 10.1001/archneurol.2009.252
   Hollingworth P, 2006, J AM GERIATR SOC, V54, P1348, DOI 10.1111/j.1532-5415.2006.00854.x
   Hwang TJ, 2004, ALZ DIS ASSOC DIS, V18, P17, DOI 10.1097/00002093-200401000-00004
   Ismail Z, 2017, J ALZHEIMERS DIS, V56, P929, DOI 10.3233/JAD-160979
   Ismail Z, 2016, ALZHEIMERS DEMENT, V12, P195, DOI 10.1016/j.jalz.2015.05.017
   Kang HS, 2010, DEMENT GERIATR COGN, V29, P82, DOI 10.1159/000264629
   Kaufer DI, 2000, J NEUROPSYCH CLIN N, V12, P233, DOI 10.1176/jnp.12.2.233
   Kolenikov S, 2004, USE DISCRETE DATA PC, V20, P1
   Lyketsos CG, 2002, JAMA-J AM MED ASSOC, V288, P1475, DOI 10.1001/jama.288.12.1475
   Masters MC, 2015, NEUROLOGY, V84, P617, DOI 10.1212/WNL.0000000000001238
   MCKHANN G, 1984, NEUROLOGY, V34, P939, DOI 10.1212/WNL.34.7.939
   Mehta KM, 2017, ALZHEIMERS DEMENT, V13, P72, DOI 10.1016/j.jalz.2016.06.2360
   Modrego PJ, 2004, ARCH NEUROL-CHICAGO, V61, P1290, DOI 10.1001/archneur.61.8.1290
   Ng TP, 2016, JAMA NEUROL, V73, P456, DOI 10.1001/jamaneurol.2015.4899
   O'Bryant SE, 2007, J PSYCHOPATHOL BEHAV, V29, P137, DOI 10.1007/s10862-006-9042-9
   O'Bryant SE, 2013, ALZHEIMERS DEMENT, V9, P622, DOI 10.1016/j.jalz.2012.12.007
   O'Bryant SE, 2013, J ALZHEIMERS DIS, V33, P373, DOI 10.3233/JAD-2012-121420
   Ortiz Freddy, 2006, Am J Alzheimers Dis Other Demen, V21, P263, DOI 10.1177/1533317506289350
   Pankratz VS, 2015, NEUROLOGY, V84, P1433, DOI 10.1212/WNL.0000000000001437
   Petersen RC, 1999, ARCH NEUROL-CHICAGO, V56, P303, DOI 10.1001/archneur.56.3.303
   Petersen RC, 2004, J INTERN MED, V256, P183, DOI 10.1111/j.1365-2796.2004.01388.x
   Rosenberg PB, 2013, AM J GERIAT PSYCHIAT, V21, P685, DOI 10.1016/j.jagp.2013.01.006
   Royall DR, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0216413
   Salazar R, 2017, J NEUROPSYCH CLIN N, V29, P13, DOI 10.1176/appi.neuropsych.15120423
   Salazar R, 2015, INT J GERIATR PSYCH, V30, P300, DOI 10.1002/gps.4141
   Sanderlin AH, 2017, FRONT AGING NEUROSCI, V9, DOI 10.3389/fnagi.2017.00164
   Santos Roberta de Oliveira, 2019, Rev. bras. epidemiol., V22, pe190041
   Schreinzer D, 2005, INT J GERIATR PSYCH, V20, P137, DOI 10.1002/gps.1263
   Spalletta G, 2010, AM J GERIAT PSYCHIAT, V18, P1026, DOI 10.1097/JGP.0b013e3181d6b68d
   Tang MX, 2001, NEUROLOGY, V56, P49, DOI 10.1212/WNL.56.1.49
   Vega IE, 2017, J ALZHEIMERS DIS, V58, P979, DOI 10.3233/JAD-161261
   Waring S., 2008, Texas Public Health Journal, V60, P9
   Yao Q, 2016, J ALZHEIMERS DIS, V51, P1175, DOI 10.3233/JAD-150920
NR 60
TC 15
Z9 15
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0891-9887
EI 1552-5708
J9 J GERIATR PSYCH NEUR
JI J. Geriatr. Psychiatry Neurol.
PD NOV
PY 2021
VL 34
IS 6
SI SI
BP 622
EP 631
AR 0891988720957087
DI 10.1177/0891988720957087
EA SEP 2020
PG 10
WC Geriatrics & Gerontology; Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Neurosciences & Neurology; Psychiatry
GA WZ4KM
UT WOS:000568526300001
PM 32909879
DA 2025-06-11
ER

PT J
AU Albini, A
   La Vecchia, C
   Magnoni, F
   Garrone, O
   Morelli, D
   Janssens, JP
   Maskens, A
   Rennert, G
   Galimberti, V
   Corso, G
AF Albini, Adriana
   La Vecchia, Carlo
   Magnoni, Francesca
   Garrone, Ornella
   Morelli, Danilo
   Janssens, Jaak Ph.
   Maskens, Alain
   Rennert, Gad
   Galimberti, Viviana
   Corso, Giovanni
TI Physical activity and exercise health benefits: cancer prevention,
   interception, and survival
SO EUROPEAN JOURNAL OF CANCER PREVENTION
LA English
DT Article
DE cancer; exercise; physical activity; prevention; therapy
ID BREAST-CANCER; LIFE-STYLE; CARDIORESPIRATORY FITNESS; INDEPENDENT
   PREDICTOR; EUROPEAN ASSOCIATION; SEDENTARY BEHAVIOR; ESC GUIDELINES;
   HEART-FAILURE; IMMUNE-SYSTEM; DOSE-RESPONSE
AB Physical activity (PA) has an established role in the promotion of health and fitness and the prevention of disease. Expected overall benefits include reduction of all-cause morbidity and death, weight control, improved quality of life, improved bone health and decreased falls of elderly subjects, , deeper cognition, and reduced risk of depression, anxiety, and sleeplessness. Currently, PA is a mainstay in the management of cardiovascular diseases, metabolic syndrome, diabetes, and bone health. Recently, the perception of its role in primary and secondary prevention, interception, and treatment of cancer, however, is also gaining importance. Regular walking, the simplest type of PA, is associated with reduced all-cause and cardiovascular disease mortality, and a role in cancer prevention is of increasing interest. Furthermore, PA improves the quality of life of cancer patients, attenuating side effects of chemotherapy, decreasing sarcopenia, increasing fitness, and inhibiting the recurrence and progression of some cancer types. It promotes emotional and psychological benefits in patients, inducing positive changes. While mechanisms, effective levels and useful amount of PA practice are well established in cardiology, they are yet to be fully determined in oncology. Nevertheless, PA is recommended to reduce cancer risk in the general population, and it has been introduced in programs for the prevention of second cancers. In perspective, it will help as integrative therapy in cancer patients and for cancer survivors. The number of beneficial effects in the cancer continuum is highlighted in this review.
C1 [Albini, Adriana] Ist Ricovero & Cura Carattere Sci IRCCS, European Inst Oncol IEO, Via Giuseppe Ripamonti 435, Bari 20141, Italy.
   [La Vecchia, Carlo] Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy.
   [Magnoni, Francesca; Galimberti, Viviana; Corso, Giovanni] European Inst Oncol IEO, Ist Ricovero & Cura Carattere Sci IRCCS, Div Breast Surg, Bari, Italy.
   [Garrone, Ornella] Fdn IRCCS CaGranda Osped Maggiore Policlin, Dept Med Oncol, Milan, Italy.
   [Morelli, Danilo] Ist Ricovero & Cura Carattere Sci IRCCS Multimed, Milan, Italy.
   [Janssens, Jaak Ph.; Maskens, Alain] European Canc Prevent Org ECP, Milan, Italy.
   [Rennert, Gad] Carmel Hosp, Haifa, Israel.
   [Rennert, Gad] Technion Fac Med, Haifa, Israel.
   [Corso, Giovanni] Univ Milan, Dept Oncol & Hematooncol, Milan, Italy.
C3 IRCCS European Institute of Oncology (IEO); University of Milan; IRCCS
   European Institute of Oncology (IEO); IRCCS Ca Granda Ospedale Maggiore
   Policlinico; Clalit Health Services; Carmel Medical Center; Technion
   Israel Institute of Technology; Rappaport Faculty of Medicine;
   University of Milan
RP Albini, A (corresponding author), Ist Ricovero & Cura Carattere Sci IRCCS, European Inst Oncol IEO, Via Giuseppe Ripamonti 435, Bari 20141, Italy.
EM adriana.albini@ieo.it
RI Romero, Atocha/AAS-2862-2021; Magnoni, Francesca/E-3147-2019; Garrone,
   Ornella/HHS-9402-2022; Corso, Giovanni/AAN-5976-2020
FU Italian Ministry of Health Ricerca Corrente; European Institute of
   Oncology; IRCCS MultiMedica, Italy
FX The authors thank Francesca Albini and Paola Corradino for their
   collaboration and William Russel Edu for helping with the bibliography.
   Editorial assistance was provided by Aashni Shah and Laura Brogelli, PhD
   (Polistudium srl, Milan, Italy); graphic assistance was provided by
   Massimiliano Pianta (Polistudium srl, Milan, Italy).This study was
   sustained through the 'Umberto Veronesi' Foundation project: 'Massive
   CDH1 genetic screening in the so-called hereditary breast-gastric cancer
   syndrome' to G.C. The work was also supported by the Italian Ministry of
   Health Ricerca Corrente to IRCCS IEO, European Institute of Oncology,
   and IRCCS MultiMedica, Italy.
CR Albini A, 2016, CLIN CANCER RES, V22, P4322, DOI 10.1158/1078-0432.CCR-16-0695
   Albini A, 2015, JNCI-J NATL CANCER I, V107, DOI 10.1093/jnci/djv213
   Aldhahi MI, 2024, ANN MED, V56, DOI 10.1080/07853890.2024.2338248
   Almuqahwi A, 2023, CUREUS J MED SCIENCE, V15, DOI 10.7759/cureus.51307
   Amer Diabet Assoc, 2018, DIABETES CARE, V41, pS38, DOI 10.2337/dc18-S004
   Amin AM, 2024, CARDIO-ONCOLOGY, V10, DOI 10.1186/s40959-024-00208-2
   Anazco Diego, 2024, Obes Pillars, V10, P100106, DOI 10.1016/j.obpill.2024.100106
   Anish RJ, 2024, J ORTHOP, V53, P101, DOI 10.1016/j.jor.2024.03.002
   [Anonymous], 2017, Diet, nutrition, physical activity and colorectal cancer
   [Anonymous], 2009, NUTR REV, V67, P114, DOI 10.1111/j.1753-4887.2008.00136.x
   [Anonymous], 2018, Physical Activity Guidelines for Americans, V2nd
   Argilés JM, 2012, J CACHEXIA SARCOPENI, V3, P73, DOI 10.1007/s13539-012-0067-5
   Aune D, 2015, EUR J EPIDEMIOL, V30, P529, DOI 10.1007/s10654-015-0056-z
   Banach M, 2023, EUR J PREV CARDIOL, V30, P1975, DOI 10.1093/eurjpc/zwad229
   Baumann FT, 2024, DTSCH ARZTEBL INT, V121, DOI 10.3238/arztebl.m2024.0038
   Beg MS, 2017, J ONCOL PRACT, V13, P82, DOI 10.1200/JOP.2016.016857
   Bellissimo MP, 2023, JACC-CARDIOONCOL, V5, P641, DOI 10.1016/j.jaccao.2022.12.011
   Bird Stephen R, 2016, BMJ Open Sport Exerc Med, V2, pe000143, DOI 10.1136/bmjsem-2016-000143
   Bonekamp NE, 2024, EUR J PREV CARDIOL, V31, P205, DOI 10.1093/eurjpc/zwad316
   Bonnet F, 2005, ATHEROSCLEROSIS, V178, P339, DOI 10.1016/j.atherosclerosis.2004.08.035
   Brittain EL, 2024, JAMA NETW OPEN, V7, DOI 10.1001/jamanetworkopen.2024.3821
   Brown JC, 2023, BRIT J SPORT MED, V57, P965, DOI 10.1136/bjsports-2022-106445
   Cailleaux PE, 2024, CURR OPIN CLIN NUTR, V27, P234, DOI 10.1097/MCO.0000000000001023
   Campbell KL, 2019, MED SCI SPORT EXER, V51, P2375, DOI 10.1249/MSS.0000000000002116
   CASPERSEN CJ, 1985, PUBLIC HEALTH REP, V100, P126
   Ceci C, 2024, J CANCER, V15, P1, DOI 10.7150/jca.88559
   Chen FJ, 2024, BMC PULM MED, V24, DOI 10.1186/s12890-024-02906-0
   Chen XL, 2023, BMC NURS, V22, DOI 10.1186/s12912-023-01363-0
   Chiang CH., 2023, Oncology
   Ciernikova S, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1285516
   Corso G, 2023, EUR J CANCER PREV, V32, P203, DOI 10.1097/CEJ.0000000000000782
   Cuff DJ, 2003, DIABETES CARE, V26, P2977, DOI 10.2337/diacare.26.11.2977
   de Boer W, 2021, SCAND J MED SCI SPOR, V31, P1342, DOI 10.1111/sms.13940
   de Boniface J, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0274804
   Diao XY, 2023, CANCER COMMUN, V43, P1229, DOI 10.1002/cac2.12488
   Dixon-Suen SC, 2022, BRIT J SPORT MED, V56, P1157, DOI 10.1136/bjsports-2021-105132
   Duan X., 2024, Mol Cell Biochem
   Dunston ER, 2023, PM&R, V15, P916, DOI 10.1002/pmrj.12882
   Erdik A, 2023, CENT EUR J UROL, V76, P81, DOI 10.5173/ceju.2023.14
   Fabi A, 2024, CURR ONCOL REP, V26, P346, DOI 10.1007/s11912-024-01500-1
   Fang X, 2024, PREV MED REP, V41, DOI 10.1016/j.pmedr.2024.102697
   Fleg JL, 2016, CIRC-HEART FAIL, V9, DOI 10.1161/CIRCHEARTFAILURE.116.003155
   Fleg JL, 2015, CIRC-HEART FAIL, V8, P209, DOI 10.1161/CIRCHEARTFAILURE.113.001420
   Francois ME, 2014, DIABETOLOGIA, V57, P1437, DOI 10.1007/s00125-014-3244-6
   Frick C, 2023, LANCET GLOB HEALTH, V11, pE1700, DOI 10.1016/S2214-109X(23)00406-0
   Fukushima N, 2024, J AM MED DIR ASSOC, V25, P417, DOI 10.1016/j.jamda.2023.09.028
   Garber CE, 2011, MED SCI SPORT EXER, V43, P1334, DOI 10.1249/MSS.0b013e318213fefb
   García-Chico C, 2023, CANCERS, V15, DOI 10.3390/cancers15010324
   Garrone O, 2021, ANN ONCOL, V32, pS429, DOI 10.1016/j.annonc.2021.08.438
   Garrone O, 2023, J CLIN ONCOL, V41
   Gillies CL, 2007, BMJ-BRIT MED J, V334, P299, DOI 10.1136/bmj.39063.689375.55
   Gnagnarella P, 2024, J CANCER SURVIV, V18, P1732, DOI 10.1007/s11764-023-01415-z
   Hackney AC, 2015, PROG MOL BIOL TRANSL, V135, P293, DOI 10.1016/bs.pmbts.2015.07.001
   Herazo-Beltrán Y, 2017, BRAZ J PHYS THER, V21, P44, DOI 10.1016/j.bjpt.2016.04.003
   Huang ZH, 2024, JAMA NETW OPEN, V7, DOI 10.1001/jamanetworkopen.2024.0219
   Hussain N, 2018, AM J CARDIOL, V121, P41, DOI 10.1016/j.amjcard.2017.09.021
   International Agency for Research on CancerCancer Today, 2024, Population factsheets
   Iyengar NM, 2019, JAMA ONCOL, V5, P1620, DOI 10.1001/jamaoncol.2019.2585
   Jenkins DG, 2023, J PHYSIOL-LONDON, V601, P4691, DOI 10.1113/JP284985
   Jones LW, 2013, CANCER PREV RES, V6, P925, DOI 10.1158/1940-6207.CAPR-12-0416
   Khadanga S, 2024, MED CLIN N AM, V108, P509, DOI 10.1016/j.mcna.2023.11.005
   Kitajima K, 2023, PLOS ONE, V18, DOI 10.1371/journal.pone.0285762
   Koelwyn GJ, 2017, NAT REV CANCER, V17, P620, DOI 10.1038/nrc.2017.78
   Koh YS, 2022, BMC PUBLIC HEALTH, V22, DOI 10.1186/s12889-022-13431-2
   Koivula T, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-33432-4
   Kouidi E, 2024, EUR J PREV CARDIOL, V31, P1493, DOI 10.1093/eurjpc/zwae130
   Kyu HH, 2016, BMJ-BRIT MED J, V354, DOI 10.1136/bmj.i3857
   Lavín-Pérez AM, 2023, SUPPORT CARE CANCER, V31, DOI 10.1007/s00520-023-07968-0
   Lee YJ, 2024, BIOCHEM BIOPHYS REP, V38, DOI 10.1016/j.bbrep.2024.101684
   Leung WKC, 2024, J EXERC SCI FIT, V22, P278, DOI 10.1016/j.jesf.2024.04.001
   Li CYL, 2024, PREV MED REP, V41, DOI 10.1016/j.pmedr.2024.102715
   Ligibel JA, 2022, J CLIN ONCOL, V40, P2491, DOI 10.1200/JCO.22.00687
   Ligibel JA, 2019, CLIN CANCER RES, V25, P5398, DOI 10.1158/1078-0432.CCR-18-3143
   Lim WA, 2017, CELL, V168, P724, DOI 10.1016/j.cell.2017.01.016
   Liu AI, 2023, CANCER NURS, DOI 10.1097/NCC.0000000000001300
   Locasale JW., 2024, Cold Spring Harb Perspect Med, pa041549
   Lönnberg L, 2019, UPSALA J MED SCI, V124, P94, DOI 10.1080/03009734.2019.1602088
   Lu Y, 2024, INT J PSYCHIAT MED, V59, P199, DOI 10.1177/00912174231190451
   Lyu D, 2024, FRONT PHYSIOL, V14, DOI 10.3389/fphys.2023.1292580
   Mali SB, 2024, ORAL ONCOL, V151, DOI 10.1016/j.oraloncology.2024.106746
   Malveiro C, 2023, J SCI MED SPORT, V26, P586, DOI 10.1016/j.jsams.2023.08.178
   Mandsager K, 2018, JAMA NETW OPEN, V1, DOI 10.1001/jamanetworkopen.2018.3605
   Masiero M, 2024, JMIR FORM RES, V8, DOI 10.2196/51021
   Mast IH, 2024, J CANCER SURVIV, V18, P1, DOI 10.1007/s11764-024-01537-y
   Matthews CE, 2020, J CLIN ONCOL, V38, P686, DOI 10.1200/JCO.19.02407
   Mendes R, 2013, REV PORT ENDOCRINOL, V8, P9, DOI 10.1016/j.rpedm.2012.05.001
   Mölenberg FJM, 2019, INT J BEHAV NUTR PHY, V16, DOI 10.1186/s12966-019-0850-1
   Moore SC, 2012, PLOS MED, V9, DOI 10.1371/journal.pmed.1001335
   Naghavi M, 2017, LANCET, V390, P1151, DOI 10.1016/S0140-6736(17)32152-9
   Ning Y, 2023, FRONT PUBLIC HEALTH, V11, DOI 10.3389/fpubh.2023.1260804
   Nyrop KA, 2024, SUPPORT CARE CANCER, V32, DOI 10.1007/s00520-023-08275-4
   Orange ST, 2023, TRENDS ENDOCRIN MET, V34, P749, DOI 10.1016/j.tem.2023.08.001
   Parvanova I, 2024, STUD HEALTH TECHNOL, V310, P1569, DOI 10.3233/SHTI231326
   Patel AV, 2019, MED SCI SPORT EXER, V51, P2391, DOI 10.1249/MSS.0000000000002117
   Patterson R, 2018, EUR J EPIDEMIOL, V33, P811, DOI 10.1007/s10654-018-0380-1
   Pelliccia A, 2021, EUR HEART J, V42, P17, DOI [10.1093/eurheartj/ehaa605, 10.1093/eurheartj/ehaa835]
   Peng WY, 2024, AM J PREVENT CARDIOL, V17, DOI 10.1016/j.ajpc.2024.100635
   Piepoli MF, 2016, EUR HEART J, V37, P2315, DOI 10.1093/eurheartj/ehw106
   Piepoli MF, 2011, EUR J HEART FAIL, V13, P347, DOI 10.1093/eurjhf/hfr017
   Powers-James C, 2024, CURR ONCOL REP, V26, P147, DOI 10.1007/s11912-023-01467-5
   Puklin LS, 2024, CANCER-AM CANCER SOC, DOI 10.1002/cncr.35280
   Qi Z, 2024, CURR PROB CARDIOLOGY, V49, DOI 10.1016/j.cpcardiol.2023.102210
   Ranes Maria, 2022, PEC Innov, V1, P100088, DOI 10.1016/j.pecinn.2022.100088
   Ren XY, 2024, BONE, V181, DOI 10.1016/j.bone.2024.117025
   Rock CL, 2022, CA-CANCER J CLIN, V72, P230, DOI 10.3322/caac.21719
   Rock CL, 2020, CA-CANCER J CLIN, V70, P245, DOI 10.3322/caac.21591
   Rogers LQ, 2023, J CANCER SURVIV, V17, P1834, DOI 10.1007/s11764-022-01329-2
   Saint-Maurice PF, 2020, JAMA-J AM MED ASSOC, V323, P1151, DOI 10.1001/jama.2020.1382
   Sanft T, 2023, J CLIN ONCOL, V41, P5285, DOI 10.1200/JCO.23.00871
   Santagnello SB, 2024, J STRENGTH COND RES, V38, P773, DOI 10.1519/JSC.0000000000004020
   Santagnello SB, 2020, SUPPORT CARE CANCER, V28, P6075, DOI 10.1007/s00520-020-05429-6
   Sattelmair J, 2011, CIRCULATION, V124, P789, DOI 10.1161/CIRCULATIONAHA.110.010710
   Savvakis I, 2024, EUR GERIATR MED, V15, P333, DOI 10.1007/s41999-024-00944-9
   Schadler KL, 2016, ONCOTARGET, V7, P65429, DOI 10.18632/oncotarget.11748
   Schmitz KH, 2019, CA-CANCER J CLIN, V69, P468, DOI 10.3322/caac.21579
   Sebri V, 2022, BEHAV SCI-BASEL, V12, DOI 10.3390/bs12080271
   SenthilKumar G, 2024, CANCER RES COMMUN, V4, P1211, DOI 10.1158/2767-9764.CRC-23-0148
   Smith AD, 2016, DIABETOLOGIA, V59, P2527, DOI 10.1007/s00125-016-4079-0
   Spanoudaki M, 2023, CANCERS, V15, DOI 10.3390/cancers15215135
   Strain T, 2023, DIABETES CARE, V46, P1145, DOI 10.2337/dc22-1467
   Strathearn LS, 2020, NUTRIENTS, V12, DOI 10.3390/nu12040933
   Stringhini S, 2010, JAMA-J AM MED ASSOC, V303, P1159, DOI 10.1001/jama.2010.297
   Sung H, 2021, CA-CANCER J CLIN, V71, P209, DOI 10.3322/caac.21660
   Suter F, 2023, EUR J CANCER PREV, V32, P328, DOI 10.1097/CEJ.0000000000000814
   Szadkowska Agnieszka, 2021, Pediatr Endocrinol Diabetes Metab, V27, P235, DOI 10.5114/pedm.2022.112620
   Thong MSY, 2020, CURR TREAT OPTION ON, V21, DOI 10.1007/s11864-020-0707-5
   Timmins IR, 2024, J CLIN ONCOL, V42, DOI 10.1200/JCO.23.01101
   Tomida S, 2024, CANCER SCI, V115, P611, DOI 10.1111/cas.16020
   Tsilingiris D, 2024, CURR OBES REP, V13, P1, DOI 10.1007/s13679-023-00542-z
   Tuomilehto J, 2001, NEW ENGL J MED, V344, P1343, DOI 10.1056/NEJM200105033441801
   Vainshelboim B, 2017, ANN EPIDEMIOL, V27, P442, DOI 10.1016/j.annepidem.2017.06.003
   Van Blarigan EL, 2024, EUR UROL ONCOL, V7, P519, DOI 10.1016/j.euo.2023.10.012
   Vasilopoulos T, 2024, ARCH GERONTOL GERIAT, V120, DOI 10.1016/j.archger.2024.105339
   Vejux Julien, 2024, Geriatr Psychol Neuropsychiatr Vieil, V19, P127, DOI 10.1684/pnv.2021.0924
   Verma V, 2021, NAT IMMUNOL, V22, P53, DOI 10.1038/s41590-020-00818-9
   Veronese N, 2023, EUR GERIATR MED, V14, P925, DOI 10.1007/s41999-023-00858-y
   Visseren FLJ, 2022, REV ESP CARDIOL, V75, P429, DOI [10.1016/j.rec.2022.04.004, 10.1016/j.rec.2022.04.003]
   Wagoner CW, 2023, SUPPORT CARE CANCER, V31, DOI 10.1007/s00520-023-08001-0
   Wang J, 2024, CIRC RES, V134, P550, DOI 10.1161/CIRCRESAHA.123.323346
   Wang X, 2024, SEMIN ONCOL NURS, V40, DOI 10.1016/j.soncn.2023.151571
   Wen CP, 2011, LANCET, V378, P1244, DOI 10.1016/S0140-6736(11)60749-6
   Wilcoxon A, 2020, ONCOL NURS FORUM, V47, P703, DOI 10.1188/20.ONF.703-719
   Wu J, 2024, PSYCHOGERIATRICS, V24, P174, DOI 10.1111/psyg.13056
   Xiao KJ, 2024, J CANCER RES CLIN, V150, DOI 10.1007/s00432-023-05546-9
   Xu J, 2022, GERONTOLOGY, V68, P361, DOI 10.1159/000517099
   Yang HY, 2023, CANCER NURS, V46, P375, DOI 10.1097/NCC.0000000000001106
   Yang L, 2021, CANCER RES, V81, P4889, DOI 10.1158/0008-5472.CAN-21-1258
   Zhang CL, 2024, INT J OCCUP MED ENV, V37, P58, DOI 10.13075/ijomeh.1896.02249
   Zhang XM, 2020, BMC CANCER, V20, DOI 10.1186/s12885-020-6645-6
   Zhang YQ, 2023, MEDICINE, V102, DOI 10.1097/MD.0000000000036646
   Zhang Y, 2024, MEDICINE, V103, DOI 10.1097/MD.0000000000037666
   Zhuang CL, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000003164
   ,, 2010, Global recommendations on physical activity for health
NR 153
TC 8
Z9 8
U1 11
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0959-8278
EI 1473-5709
J9 EUR J CANCER PREV
JI Eur. J. Cancer Prev.
PD JAN
PY 2025
VL 34
IS 1
BP 24
EP 39
DI 10.1097/CEJ.0000000000000898
PG 16
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA O8Q1M
UT WOS:001373697400009
PM 38920329
DA 2025-06-11
ER

PT J
AU Pompili, M
   Venturini, P
   Lamis, DA
   Giordano, G
   Serafini, G
   Murri, MB
   Amore, M
   Girardi, P
AF Pompili, Maurizio
   Venturini, Paola
   Lamis, Dorian A.
   Giordano, Gloria
   Serafini, Gianluca
   Murri, Martino Belvederi
   Amore, Mario
   Girardi, Paolo
TI Suicide in Stroke Survivors: Epidemiology and Prevention
SO DRUGS & AGING
LA English
DT Review
ID CARDIOVASCULAR RISK-FACTORS; LATE-LIFE DEPRESSION; QUALITY-OF-LIFE;
   POSTSTROKE DEPRESSION; ANTIDEPRESSANT TREATMENT; BIPOLAR-DISORDER;
   DOUBLE-BLIND; METABOLIC SYNDROME; MAJOR DEPRESSION; MEDICAL ILLNESS
AB Stroke is a dramatic event and is associated with potentially severe consequences, including disability, mortality, and social costs. Stroke may occur at any age; however, most strokes occur in individuals aged 65 years and older. Previous research has found that stroke increases suicide risk, especially among women and younger patients. The aim of the current review is to investigate the relationship between suicide and stroke in order to determine which stroke patients are at elevated risk for suicide. Moreover, we review the literature in order to provide pharmacological treatment strategies for stroke patients at high risk of suicide. We performed a careful search to identify articles and book chapters focused on this issue, selecting only English-language articles published from 1990 to 2014 that addressed the issue of suicide after stroke and its pharmacological management. We found 12 clinical trials that explored the relationship between stroke and suicidal ideation and/or suicidal plans and 11 investigating suicide as the cause of death after stroke. We identified stroke as a significant risk factor for both suicide and suicidal ideation, especially among younger adult depressed patients in all articles, providing further support for the association between post-stroke and suicidality. Suicide risk is particularly high in the first 5 years following stroke. Depression, previous mood disorder, prior history of stroke, and cognitive impairment were found to be the most important risk factors for suicide. Selective serotonin reuptake inhibitors (SSRIs) represent the treatment of choice for stroke survivors with suicide risk, and studies in rats have suggested that carbolithium is a promising treatment in these patients. Early identification and treatment of post-stroke depression may significantly reduce suicide risk in stroke patients.
C1 [Pompili, Maurizio; Venturini, Paola; Giordano, Gloria; Girardi, Paolo] Univ Roma La Sapienza, Dept Neurosci Mental Hlth & Sensory Organs, Suicide Prevent Ctr, St Andrea Hosp, I-00189 Rome, Italy.
   [Lamis, Dorian A.] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA.
   [Serafini, Gianluca; Murri, Martino Belvederi; Amore, Mario] Univ Genoa, Sect Psychiat, Dept Neurosci Rehabi ,Ophthalmol Gene Maternal &, Genoa, Italy.
C3 Sapienza University Rome; Azienda Ospedaliera Sant'Andrea; Emory
   University; University of Genoa
RP Pompili, M (corresponding author), Univ Roma La Sapienza, Dept Neurosci Mental Hlth & Sensory Organs, Suicide Prevent Ctr, St Andrea Hosp, 1035-1039 Via Grottarossa, I-00189 Rome, Italy.
EM maurizio.pompili@uniroma1.it
RI Lamis, Dorian/AAM-3651-2020; Pompili, Maurizio/AAC-1011-2019; Altamura,
   Mario/IQS-2773-2023; Belvederi Murri, Martino/G-8781-2011; Serafini,
   Gianluca/K-6603-2016
OI Belvederi Murri, Martino/0000-0002-7262-3528; Serafini,
   Gianluca/0000-0002-6631-856X; Lamis, Dorian/0000-0001-5405-0239;
   Pompili, Maurizio/0000-0003-1886-4977
CR [Anonymous], 2004, ATLAS HEART DIS STRO
   [Anonymous], COCHRANE DATABASE SY
   Arciniegas David B., 2002, Curr Treat Options Neurol, V4, P457, DOI 10.1007/s11940-002-0013-5
   Baldessarini RJ, 2005, CLIN NEUROPSYCHIATR, V2, P73
   Baldwin RC, 2010, INT PSYCHOGERIATR, V22, P1216, DOI 10.1017/S1041610210000864
   Barbui C, 2014, EPIDEMIOL PSYCHIAT S, V14, P1
   Bates KA, 2015, RESTOR NEUROL NEUROS, V33, P557, DOI 10.3233/RNN-130359
   Beekman ATF, 1998, SOC PSYCH PSYCH EPID, V33, P463, DOI 10.1007/s001270050080
   Bilge C, 2008, EUR J PHYS REHAB MED, V44, P13
   Birkenaes AB, 2007, J CLIN PSYCHIAT, V68, P917, DOI 10.4088/JCP.v68n0614
   Bronnum-Hansen H, 2001, STROKE, V32, P2131, DOI 10.1161/hs0901.094253
   Capaldi VF, 2010, PSYCHOL RES BEHAV MA, V3, P109, DOI 10.2147/PRBM.S10035
   Carota Antonio, 2003, Adv Neurol, V92, P435
   Cassidy F, 1999, AM J PSYCHIAT, V156, P1417
   Centers for Disease Control and Prevention, 2013, CDC VIT PREV DEATHS
   Chan KL, 2006, ARCH PHYS MED REHAB, V87, P793, DOI 10.1016/j.apmr.2006.02.016
   Chan SS, 2007, AM J GERIAT PSYCHIAT, V15, P541, DOI 10.1097/JGP.0b013e31803c5523
   Choi-Kwon S, 2007, CEREBROVASC DIS, V23, P103, DOI 10.1159/000097045
   Conn DK, 1997, INT J PSYCHIAT MED, V27, P269, DOI 10.2190/J309-EJMX-WHRM-4UYG
   Coupland C, 2011, BMJ-BRIT MED J, V343, DOI 10.1136/bmj.d4551
   Cravello L, 2009, HUM PSYCHOPHARM CLIN, V24, P331, DOI 10.1002/hup.1021
   Crump C, 2014, PSYCHOL MED, V44, P279, DOI 10.1017/S0033291713000810
   Davis J, 2008, AM J MANAG CARE, V14, P125
   de Coster L, 2005, INT J GERIATR PSYCH, V20, P358, DOI 10.1002/gps.1290
   Di Carlo A, 2009, AGE AGEING, V38, P4, DOI 10.1093/ageing/afn282
   Eaton WW, 1996, DIABETES CARE, V19, P1097, DOI 10.2337/diacare.19.10.1097
   Ellis C, 2010, J PSYCHOSOM RES, V68, P545, DOI 10.1016/j.jpsychores.2009.11.006
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   FAWCETT J, 1990, AM J PSYCHIAT, V147, P1189
   Fiedorowicz JG, 2008, ANN CLIN PSYCHIATRY, V20, P131, DOI 10.1080/10401230802177722
   Flaster M, 2013, TOP STROKE REHABIL, V20, P139, DOI 10.1310/tsr2002-139
   Forsström E, 2010, J NEUROPSYCH CLIN N, V22, P182, DOI 10.1176/appi.neuropsych.22.2.182
   Fregni Felipe, 2005, Curr Psychiatry Rep, V7, P381, DOI 10.1007/s11920-005-0041-4
   Fuller-Thomson E, 2012, INT J STROKE, V7, P188, DOI 10.1111/j.1747-4949.2011.00702.x
   GARDEN FH, 1990, ARCH PHYS MED REHAB, V71, P1003
   Golden SH, 2008, JAMA-J AM MED ASSOC, V299, P2751, DOI 10.1001/jama.299.23.2751
   Gottfries CG, 2001, EUR ARCH PSY CLIN N, V251, P57, DOI 10.1007/BF03035129
   Graven C, 2011, BMC NEUROL, V11, DOI 10.1186/1471-2377-11-73
   Gustavsson A, 2011, EUR NEUROPSYCHOPHARM, V21, P718, DOI 10.1016/j.euroneuro.2011.08.008
   Hackett ML, 2010, INT J STROKE, V5, P52, DOI 10.1111/j.1747-4949.2009.00388.x
   Hadidi N, 2009, HEART LUNG, V38, P151, DOI 10.1016/j.hrtlng.2008.05.002
   Harmandayan M, 2012, GEN HOSP PSYCHIAT, V34
   Harris EC, 1997, BRIT J PSYCHIAT, V170, P205, DOI 10.1192/bjp.170.3.205
   Hawton K, 2009, LANCET, V373, P1372, DOI [10.1016/S0140-6736(09)60372-X, 10.1016/S0140-6736(13)62118-2]
   Huang H, 2012, NEUROSCIENCES, V17, P53
   Johannessen L, 2006, J AFFECT DISORDERS, V95, P13, DOI 10.1016/j.jad.2006.03.027
   Joiner TE, 2005, J ABNORM PSYCHOL, V114, P291, DOI 10.1037/0021-843X.114.2.291
   Jorge RE, 2003, AM J PSYCHIAT, V160, P1823, DOI 10.1176/appi.ajp.160.10.1823
   Joubert J, 2008, CEREBROVASC DIS, V26, P199, DOI 10.1159/000145328
   Juurlink DN, 2004, ARCH INTERN MED, V164, P1179, DOI 10.1001/archinte.164.11.1179
   Katayama M, 2010, KOBE J MED SCI, V56, P184
   Kilbourne AM, 2004, BIPOLAR DISORD, V6, P368, DOI 10.1111/j.1399-5618.2004.00138.x
   Kim BR, 2010, AM J PHYS MED REHAB, V89, P362, DOI 10.1097/PHM.0b013e3181d8a5b1
   Kim J-M, 2013, AM J GERIATR PSYCHIA
   Kishi Y, 1996, J NERV MENT DIS, V184, P274, DOI 10.1097/00005053-199605000-00002
   Kishi Y, 1996, Int Psychogeriatr, V8, P623, DOI 10.1017/S1041610296002931
   Kong KH, 2004, ARCH PHYS MED REHAB, V85, P35, DOI 10.1016/S0003-9993(03)00369-1
   Lee HC, 2008, BIOL PSYCHIAT, V64, P912, DOI 10.1016/j.biopsych.2008.07.006
   Lincoln NB, 1997, CLIN REHABIL, V11, P114, DOI 10.1177/026921559701100204
   Lloyd-Jones D, 2010, CIRCULATION, V121, pE46, DOI 10.1161/CIRCULATIONAHA.109.192667
   MACKENZIE TB, 1987, INT J PSYCHIAT MED, V17, P3
   McElroy SL, 2002, J CLIN PSYCHIAT, V63, P207, DOI 10.4088/JCP.v63n0306
   Meyer CM, 2004, J AFFECT DISORDERS, V83, P127, DOI 10.1016/j.jad.2004.06.004
   Mezuk B, 2008, AM J PUBLIC HEALTH, V98, P1480, DOI 10.2105/AJPH.2007.126441
   Mikami K, 2011, AM J GERIAT PSYCHIAT, V19, P1007, DOI 10.1097/JGP.0b013e31821181b0
   Möller HJ, 2008, EUR ARCH PSY CLIN N, V258, P3, DOI 10.1007/s00406-008-3002-1
   Mukherjee D, 2011, WORLD NEUROSURG, V76, pS85, DOI 10.1016/j.wneu.2011.07.023
   Narushima K, 2003, J NERV MENT DIS, V191, P645, DOI 10.1097/01.nmd.0000092197.97693.d2
   Niedermaier N, 2004, J CLIN PSYCHIAT, V65, P1619, DOI 10.4088/JCP.v65n1206
   Nuyen J, 2008, STROKE, V39, P132, DOI 10.1161/STROKEAHA.107.490565
   Paolucci Stefano, 2008, Neuropsychiatr Dis Treat, V4, P145
   Park SM, 2014, J MENT HEALTH, V23, P94, DOI 10.3109/09638237.2013.869569
   Patten SB, 2008, GEN HOSP PSYCHIAT, V30, P407, DOI 10.1016/j.genhosppsych.2008.05.001
   Placido A, 2009, INT J CARDIOL, V135, P261, DOI 10.1016/j.ijcard.2008.03.034
   Pohjasvaara T, 2001, CEREBROVASC DIS, V12, P21, DOI 10.1159/000047676
   Pompili M, 2011, MINERVA PSICHIAT, V52, P61
   Pompili M, 2005, CLIN NEUROPSYCHIATR, V2, P66
   Pompili M, 2012, CNS NEUROSCI THER, V18, P711, DOI 10.1111/j.1755-5949.2012.00364.x
   Pompili M, 2009, EXPERT REV NEUROTHER, V9, P109, DOI 10.1586/14737175.9.1.109
   Pritchard C, 2005, INT J GERIATR PSYCH, V20, P17, DOI 10.1002/gps.1213
   Quan H, 2002, SOC PSYCH PSYCH EPID, V37, P190, DOI 10.1007/s001270200014
   Rao R, 1999, STROKE, V30, P2167, DOI 10.1161/01.STR.30.10.2167
   Raskind MA, 2008, AM J MED, V121, P28, DOI 10.1016/j.amjmed.2008.09.011
   Rasmussen A, 2003, PSYCHOSOMATICS, V44, P216, DOI 10.1176/appi.psy.44.3.216
   Riva-Posse P, 2013, PSYCHIAT CLIN N AM, V36, P607, DOI 10.1016/j.psc.2013.08.007
   Santos CO, 2012, J STROKE CEREBROVASC, V21, P749, DOI 10.1016/j.jstrokecerebrovasdis.2011.04.001
   Saravane D, 2009, ENCEPHALE, V35, P330, DOI 10.1016/j.encep.2008.10.014
   Scott KM, 2010, PSYCHOSOM MED, V72, P712, DOI 10.1097/PSY.0b013e3181e3333d
   Shah Amy, 2006, Ann Clin Psychiatry, V18, P239, DOI 10.1080/10401230600948423
   Shima Satoru, 1997, Keio Journal of Medicine, V46, P25
   Shin KM, 2013, AGING MENT HEALTH, V17, P109, DOI 10.1080/13607863.2012.702732
   Sokero TP, 2005, BRIT J PSYCHIAT, V186, P314, DOI 10.1192/bjp.186.4.314
   Staub F, 2001, EUR NEUROL, V45, P3, DOI 10.1159/000052081
   Stenager EN, 1998, BRIT MED J, V316, P1206, DOI 10.1136/bmj.316.7139.1206
   Tang WK, 2013, ARCH PHYS MED REHAB, V94, P863, DOI 10.1016/j.apmr.2012.11.044
   Tang WK, 2011, ARCH PHYS MED REHAB, V92, P2025, DOI 10.1016/j.apmr.2011.06.030
   Tang WK, 2011, ARCH PHYS MED REHAB, V92, P1336, DOI 10.1016/j.apmr.2011.02.018
   Teasdale TW, 2001, J EPIDEMIOL COMMUN H, V55, P863, DOI 10.1136/jech.55.12.863
   Thome J, 2015, J NEURAL TRANSM, V122, P3, DOI 10.1007/s00702-013-1126-6
   Tran J, 2010, J NEUROL SCI, V295, P38, DOI 10.1016/j.jns.2010.05.016
   van de Port IGL, 2007, CEREBROVASC DIS, V23, P40, DOI 10.1159/000095757
   Voaklander DC, 2008, J EPIDEMIOL COMMUN H, V62, P138, DOI 10.1136/jech.2006.055533
   Webb, 2012, ARCH GEN PSYCHIAT, V69, P671
   Williams LS, 2005, SEMIN NEUROL, V25, P396, DOI 10.1055/s-2005-923534
   Williams LS, 2004, AM J PSYCHIAT, V161, P1090, DOI 10.1176/appi.ajp.161.6.1090
   Yamauchi T, 2014, PSYCHOSOM MED, V76, P452, DOI 10.1097/PSY.0000000000000079
   YATES WR, 1987, J AFFECT DISORDERS, V12, P129, DOI 10.1016/0165-0327(87)90004-8
   Younes N, 2015, J AFFECT DISORDERS, V170, P150, DOI 10.1016/j.jad.2014.08.037
   Yuan HW, 2014, NEUROL SCI, V35, P171, DOI 10.1007/s10072-013-1464-z
   Zorowitz Richard D, 2005, Top Stroke Rehabil, V12, P37
NR 110
TC 77
Z9 82
U1 2
U2 25
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 1170-229X
EI 1179-1969
J9 DRUG AGING
JI Drugs Aging
PD JAN
PY 2015
VL 32
IS 1
BP 21
EP 29
DI 10.1007/s40266-014-0233-x
PG 9
WC Geriatrics & Gerontology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Pharmacology & Pharmacy
GA AY8NN
UT WOS:000347810600003
PM 25491561
DA 2025-06-11
ER

PT J
AU Owczarczyk-Saczonek, A
   Krajewska-Wlodarczyk, M
   Kruszewska, A
   Banasiak, L
   Placek, W
   Maksymowicz, W
   Wojtkiewicz, J
AF Owczarczyk-Saczonek, Agnieszka
   Krajewska-Wlodarczyk, Magdalena
   Kruszewska, Anna
   Banasiak, Lukasz
   Placek, Waldemar
   Maksymowicz, Wojciech
   Wojtkiewicz, Joanna
TI Therapeutic Potential of Stem Cells in Follicle Regeneration
SO STEM CELLS INTERNATIONAL
LA English
DT Review
ID DERMAL PAPILLA CELLS; HAIR FOLLICLE; CONDITIONED MEDIA;
   WNT/BETA-CATENIN; ADIPOSE-TISSUE; UMBILICAL-CORD; BONE-MARROW; TGF-BETA;
   ACTIVATION; GROWTH
AB Alopecia is caused by a variety of factors which affect the hair cycle and decrease stem cell activity and hair follicle regeneration capability. This process causes lower self-acceptance, which may result in depression and anxiety. However, an early onset of androgenic alopecia is associated with an increased incidence of the metabolic syndrome and an increased risk of the cardiac ischaemic disease. The ubiquity of alopecia provides an encouragement to seek new, more effective therapies aimed at hair follicle regeneration and neoregeneration. We know that stem cells can be used to regenerate hair in several therapeutic strategies: reversing the pathological mechanisms which contribute to hair loss, regeneration of complete hair follicles from their parts, and neogenesis of hair follicles from a stem cell culture with isolated cells or tissue engineering. Hair transplant has become a conventional treatment technique in androgenic alopecia (micrografts). Although an autologous transplant is regarded as the gold standard, its usability is limited, because of both a limited amount of material and a reduced viability of cells obtained in this way. The new therapeutic options are adipose-derived stem cells and stem cells from Wharton's jelly. They seem an ideal cell population for use in regenerative medicine because of the absence of immunogenic properties and their ease of obtainment, multipotential character, ease of differentiating into various cell lines, and considerable potential for angiogenesis. In this article, we presented advantages and limitations of using these types of cells in alopecia treatment.
C1 [Owczarczyk-Saczonek, Agnieszka; Kruszewska, Anna; Placek, Waldemar] Univ Warmia & Mazury, Dept Dermatol Sexually Transmitted Dis & Clin Imm, Olsztyn, Poland.
   [Krajewska-Wlodarczyk, Magdalena] Univ Warmia & Mazury, Dept Rheumatol, Olsztyn, Poland.
   [Banasiak, Lukasz] Nicolaus Copernicus Univ Torun, L Rydygier Coll Med Bydgoszcz, Dept Plast Reconstruct & Aesthet Surg, Torun, Poland.
   [Maksymowicz, Wojciech] Univ Warmia & Mazury, Fac Med Sci, Dept Neurol & Neurosurg, Olsztyn, Poland.
   [Wojtkiewicz, Joanna] Univ Warmia & Mazury, Fdn Nerve Cell Regenerat, Olsztyn, Poland.
   [Wojtkiewicz, Joanna] Univ Warmia & Mazury, Fac Med Sci, Dept Pathophysiol, Olsztyn, Poland.
   [Wojtkiewicz, Joanna] Univ Warmia & Mazury, Fac Med Sci, Lab Regenerat Med, Olsztyn, Poland.
C3 University of Warmia & Mazury; University of Warmia & Mazury; Nicolaus
   Copernicus University; University of Warmia & Mazury; University of
   Warmia & Mazury; University of Warmia & Mazury; University of Warmia &
   Mazury
RP Owczarczyk-Saczonek, A (corresponding author), Univ Warmia & Mazury, Dept Dermatol Sexually Transmitted Dis & Clin Imm, Olsztyn, Poland.
EM aganek@wp.pl
RI Banasiak, Lukasz/AAU-3332-2021; Owczarczyk-Saczonek,
   Agnieszka/AAN-5260-2020; Wojtkiewicz, Joanna/AAD-8911-2019;
   Krajewska-Wlodarczyk, Magdalena/R-6218-2018
OI Krajewska-Wlodarczyk, Magdalena/0000-0002-7857-347X; Wojtkiewicz,
   Joanna/0000-0003-0856-3644
CR Adil A, 2017, J AM ACAD DERMATOL, V77, P136, DOI 10.1016/j.jaad.2017.02.054
   Agabalyan NA, 2017, STEM CELL TRANSL MED, V6, P434, DOI 10.5966/sctm.2016-0133
   Ali N, 2017, CELL, V169, P1119, DOI 10.1016/j.cell.2017.05.002
   Aljitawi OS, 2013, STEM CELLS DEV, V22, P18, DOI 10.1089/scd.2012.0184
   Amalia Pasolli H., 2014, MICROSC MICROANAL, V20, P1382
   Anderi R, 2018, STEM CELL RES THER, V9, DOI 10.1186/s13287-018-0889-y
   Asakawa K, 2012, SCI REP-UK, V2, DOI 10.1038/srep00424
   Biernaskie J, 2009, CELL STEM CELL, V5, P610, DOI 10.1016/j.stem.2009.10.019
   Blanpain C, 2004, CELL, V118, P635, DOI 10.1016/j.cell.2004.08.012
   Brownell I, 2011, CELL STEM CELL, V8, P552, DOI 10.1016/j.stem.2011.02.021
   Castellana D, 2014, PLOS BIOL, V12, DOI 10.1371/journal.pbio.1002002
   Christoph T, 2000, BRIT J DERMATOL, V142, P862, DOI 10.1046/j.1365-2133.2000.03464.x
   Cole JP, 2013, FACIAL PLAST SURG CL, V21, P437, DOI 10.1016/j.fsc.2013.05.009
   Cranwell WC, 2017, AUSTRALAS J DERMATOL, V58, pE94, DOI 10.1111/ajd.12499
   Demehri S, 2009, DEVELOPMENT, V136, P891, DOI 10.1242/dev.030700
   Deschene ER, 2014, SCIENCE, V343, P1353, DOI 10.1126/science.1248373
   Dong L, 2017, STEM CELLS INT, V2017, DOI 10.1155/2017/3738071
   Driskell RR, 2011, J CELL SCI, V124, P1179, DOI 10.1242/jcs.082446
   Du KT, 2018, TISSUE ENG REGEN MED, V15, P341, DOI 10.1007/s13770-018-0118-x
   El Sakka Dalia, 2016, J Cutan Aesthet Surg, V9, P165
   Elmaadawi IH, 2018, J DERMATOL TREAT, V29, P431, DOI 10.1080/09546634.2016.1227419
   Enshell-Seijffers D, 2010, DEV CELL, V18, P633, DOI 10.1016/j.devcel.2010.01.016
   Estrach S, 2006, DEVELOPMENT, V133, P4427, DOI 10.1242/dev.02644
   Balañá ME, 2015, WORLD J STEM CELLS, V7, P711, DOI 10.4252/wjsc.v7.i4.711
   Festa E, 2011, CELL, V146, P761, DOI 10.1016/j.cell.2011.07.019
   Foitzik K, 1999, DEV BIOL, V212, P278, DOI 10.1006/dbio.1999.9325
   Foitzik K, 2000, FASEB J, V14, P752, DOI 10.1096/fasebj.14.5.752
   Fukuoka Hirotaro, 2015, Eplasty, V15, pe10
   Garza Luis A, 2012, Sci Transl Med, V4, p126ra34, DOI 10.1126/scitranslmed.3003122
   Gaur M, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18010208
   Gay D, 2013, NAT MED, V19, P916, DOI 10.1038/nm.3181
   Gentile Pietro, 2017, Stem Cell Investig, V4, P58, DOI 10.21037/sci.2017.06.04
   Greco V, 2009, CELL STEM CELL, V4, P155, DOI 10.1016/j.stem.2008.12.009
   Guasch G, 2017, Biology and engineering of stem cell niches, P127
   GUO LF, 1993, EMBO J, V12, P973, DOI 10.1002/j.1460-2075.1993.tb05738.x
   Halloy J, 2000, P NATL ACAD SCI USA, V97, P8328, DOI 10.1073/pnas.97.15.8328
   Higgins CA, 2014, P NATL ACAD SCI USA, V111, P10648, DOI 10.1073/pnas.1402862111
   Hoeck JD, 2017, NAT CELL BIOL, V19, P666, DOI 10.1038/ncb3535
   Hoffman RM, 2018, METHODS MOL BIOL, V1760, P133, DOI 10.1007/978-1-4939-7745-1_14
   Hoi CSL, 2010, MOL CELL BIOL, V30, P2518, DOI 10.1128/MCB.01308-09
   Horsley V, 2008, CELL, V132, P299, DOI 10.1016/j.cell.2007.11.047
   Huang CYY, 2016, J SPACE WEATHER SPAC, V6, DOI 10.1051/swsc/2015041
   Hwang I, 2016, CELL TRANSPLANT, V25, P1439, DOI 10.3727/096368916X691466
   Inoue K, 2009, LAB INVEST, V89, P844, DOI 10.1038/labinvest.2009.48
   Ito Y, 2007, J INVEST DERMATOL, V127, P1052, DOI 10.1038/sj.jid.5700665
   Jadalannagari S., 2017, PLOS ONE, V12, P1, DOI [10.1371/journal.pone.0172098, DOI 10.1371/JOURNAL.PONE.0172098]
   Jahoda CAB, 2003, EXP DERMATOL, V12, P849, DOI 10.1111/j.0906-6705.2003.00161.x
   Jaks V, 2008, NAT GENET, V40, P1291, DOI 10.1038/ng.239
   Jensen KB, 2009, CELL STEM CELL, V4, P427, DOI 10.1016/j.stem.2009.04.014
   Jong MC, 1998, J CLIN INVEST, V101, P145, DOI 10.1172/JCI791
   Kadaja M, 2014, GENE DEV, V28, P328, DOI 10.1101/gad.233247.113
   Kalabusheva E, 2017, STEM CELLS INT, V2017, DOI 10.1155/2017/9271869
   Kandyba E, 2014, STEM CELLS, V32, P886, DOI 10.1002/stem.1599
   Kang BM, 2012, J INVEST DERMATOL, V132, P237, DOI 10.1038/jid.2011.250
   Kim M, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0035100, 10.1371/journal.pone.0048287]
   Kimura-Ueki M, 2012, J INVEST DERMATOL, V132, P1338, DOI 10.1038/jid.2011.490
   Kobielak K, 2007, P NATL ACAD SCI USA, V104, P10063, DOI 10.1073/pnas.0703004104
   Krieger K, 2018, J INVEST DERMATOL, V138, P256, DOI 10.1016/j.jid.2017.08.042
   Lei MX, 2014, EXP DERMATOL, V23, P407, DOI 10.1111/exd.12416
   LESKO SM, 1993, JAMA-J AM MED ASSOC, V269, P998, DOI 10.1001/jama.269.8.998
   Li J, 2013, J INVEST DERMATOL, V133, P1450, DOI 10.1038/jid.2012.511
   Lin HY, 2011, PLOS ONE, V6, DOI [10.1371/journal.pone.0015842, 10.1371/journal.pone.0019135]
   Lin WH, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/730139
   Matsuzaki Takashi, 1998, Wound Repair and Regeneration, V6, P524, DOI 10.1046/j.1524-475X.1998.60605.x
   McElwee KJ, 2003, J INVEST DERMATOL, V121, P1267, DOI 10.1111/j.1523-1747.2003.12568.x
   Means AL, 2008, GENESIS, V46, P318, DOI 10.1002/dvg.20397
   Mecklenburg L, 2000, J INVEST DERMATOL, V114, P909, DOI 10.1046/j.1523-1747.2000.00954.x
   Mill P, 2003, GENE DEV, V17, P282, DOI 10.1101/gad.1038103
   Millar SE, 1999, DEV BIOL, V207, P133, DOI 10.1006/dbio.1998.9140
   Misago N, 1998, BRIT J DERMATOL, V139, P40
   Mohammadi P, 2016, STEM CELLS DEV, V25, P1767, DOI 10.1089/scd.2016.0137
   Mohyeldin A, 2010, CELL STEM CELL, V7, P150, DOI 10.1016/j.stem.2010.07.007
   Nakamura M, 2013, J DERMATOL SCI, V69, P6, DOI 10.1016/j.jdermsci.2012.10.001
   Nilforoushzadeh M, 2017, CELL J, V19, P259, DOI 10.22074/cellj.2016.3916
   Öztürk ÖA, 2015, CELL REP, V13, P561, DOI 10.1016/j.celrep.2015.09.015
   Oh JW, 2016, J INVEST DERMATOL, V136, P34, DOI 10.1038/JID.2015.354
   Ohyama M, 2006, J CLIN INVEST, V116, P249, DOI 10.1172/JCI26043
   Oro AE, 2003, DEV BIOL, V255, P238, DOI 10.1016/S0012-1606(02)00042-8
   Osaka N, 2007, J CELL BIOL, V176, P903, DOI 10.1083/jcb.200611015
   Oshimori N, 2012, CELL STEM CELL, V10, P63, DOI 10.1016/j.stem.2011.11.005
   Ozawa M, 2004, EXP DERMATOL, V13, P401, DOI 10.1111/j.0906-6705.2004.00153.x
   Park B-S., 2010, BIOMED RES INT, V31
   Paus R, 2005, TRENDS IMMUNOL, V26, P32, DOI 10.1016/j.it.2004.09.014
   Perez-Meza D, 2017, STEM CELLS CLONING, V10, P1, DOI 10.2147/SCCAA.S131431
   Petiot A, 2003, DEVELOPMENT, V130, P5493, DOI 10.1242/dev.00788
   Plikus MV, 2008, NATURE, V451, P340, DOI 10.1038/nature06457
   Purba TS, 2014, BIOESSAYS, V36, P513, DOI 10.1002/bies.201300166
   Qiu WM, 2017, HISTOCHEM CELL BIOL, V147, P749, DOI 10.1007/s00418-017-1540-1
   Rabbani P, 2011, CELL, V145, P941, DOI 10.1016/j.cell.2011.05.004
   Ramdasi Sushilkumar, 2016, J Stem Cells, V11, P201
   Rendl M, 2005, PLOS BIOL, V3, P1910, DOI 10.1371/journal.pbio.0030331
   Rendl M, 2008, GENE DEV, V22, P543, DOI 10.1101/gad.1614408
   Rezza A, 2015, EXP DERMATOL, V24, P468, DOI 10.1111/exd.12672
   Richardson SM, 2016, METHODS, V99, P69, DOI 10.1016/j.ymeth.2015.09.015
   Rodrigues CAV, 2011, BIOTECHNOL ADV, V29, P815, DOI 10.1016/j.biotechadv.2011.06.009
   Rompolas P, 2014, SEMIN CELL DEV BIOL, V25, P34, DOI 10.1016/j.semcdb.2013.12.005
   Rompolas P, 2013, NATURE, V502, P513, DOI 10.1038/nature12602
   Sabapathy V, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0093726
   Sellheyer K, 2011, BRIT J DERMATOL, V164, P141, DOI 10.1111/j.1365-2133.2010.10045.x
   Seo CH, 2016, ANN DERMATOL, V28, P662, DOI 10.5021/ad.2016.28.5.662
   Shin H, 2017, CURR STEM CELL RES T, V12, P524, DOI 10.2174/1574888X12666170504120244
   Shin H, 2015, INT J DERMATOL, V54, P730, DOI 10.1111/ijd.12650
   Snippert HJ, 2010, SCIENCE, V327, P1385, DOI 10.1126/science.1184733
   St-Jacques B, 1998, CURR BIOL, V8, P1058, DOI 10.1016/S0960-9822(98)70443-9
   Tanimura S, 2011, CELL STEM CELL, V8, P177, DOI 10.1016/j.stem.2010.11.029
   Telerman SB, 2017, J INVEST DERMATOL, V137, P2270, DOI 10.1016/j.jid.2017.06.015
   Tsai SY, 2010, STEM CELLS, V28, P221, DOI 10.1002/stem.281
   Turksen K., 2015, Tissue-specific stem cell niche
   Wang QS, 2016, HUM VACC IMMUNOTHER, V12, P85, DOI 10.1080/21645515.2015.1030549
   Won CH, 2010, J DERMATOL SCI, V57, P134, DOI 10.1016/j.jdermsci.2009.10.013
   Wood S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0091574
   Wu Minjuan, 2012, Cell Biol Int Rep (2010), V19, pe00019, DOI 10.1042/CBR20120003
   Yang Y, 2016, STEM CELL RES THER, V7, DOI 10.1186/s13287-016-0313-4
   Yano K, 2001, J CLIN INVEST, V107, P409, DOI 10.1172/JCI11317
   Yi R, 2017, STEM CELLS, V35, P2323, DOI 10.1002/stem.2696
   Yoo BY, 2010, J DERMATOL SCI, V60, P74, DOI 10.1016/j.jdermsci.2010.08.017
   Yoo BY, 2010, BIOCHEM ENG J, V48, P323, DOI 10.1016/j.bej.2009.09.008
   Yoo BY, 2010, BIOTECHNOL BIOPROC E, V15, P182, DOI 10.1007/s12257-009-3050-z
   Zanzottera F, 2014, J Cosmet Dermatological Sci Appl, V4, P268, DOI [DOI 10.4236/JCDSA.2014.44036, 10.4236/jcdsa.2014.44036]
   Zhang PP, 2014, J TISSUE ENG, V5, DOI 10.1177/2041731414556850
   Zhou LJ, 2018, BIOCHEM BIOPH RES CO, V500, P325, DOI 10.1016/j.bbrc.2018.04.067
   Zhu M, 2010, ANN PLAS SURG, V64, P222, DOI 10.1097/SAP.0b013e31819ae05c
NR 122
TC 52
Z9 56
U1 1
U2 14
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-966X
EI 1687-9678
J9 STEM CELLS INT
JI Stem Cells Int.
PY 2018
VL 2018
AR 1049641
DI 10.1155/2018/1049641
PG 16
WC Cell & Tissue Engineering
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA GQ8KK
UT WOS:000442003100001
PM 30154860
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Deveaux, A
   Pham, I
   West, SG
   André, E
   Lantoine-Adam, F
   Bunouf, P
   Sadi, S
   Hermier, D
   Mathé, V
   Fouillet, H
   Huneau, JF
   Benamouzig, R
   Mariotti, F
AF Deveaux, Ambre
   Pham, Isabelle
   West, Sheila G.
   Andre, Etienne
   Lantoine-Adam, Frederique
   Bunouf, Pierre
   Sadi, Samira
   Hermier, Dominique
   Mathe, Veronique
   Fouillet, Helene
   Huneau, Jean-Francois
   Benamouzig, Robert
   Mariotti, Francois
TI L-Arginine Supplementation Alleviates Postprandial Endothelial
   Dysfunction When Baseline Fasting Plasma Arginine Concentration Is Low:
   A Randomized Controlled Trial in Healthy Overweight Adults with
   Cardiometabolic Risk Factors
SO JOURNAL OF NUTRITION
LA English
DT Article
DE arginine metabolism; cardiometabolic risk; dietary arginine; high-fat
   meal; postprandial period
ID FLOW-MEDIATED DILATION; NITRIC-OXIDE SYNTHESIS; HIGH-FAT MEAL; OXIDATIVE
   STRESS GENERATION; PULSE AMPLITUDE TONOMETRY; TEST-RETEST RELIABILITY;
   ORAL L-ARGININE; ASYMMETRIC DIMETHYLARGININE; SIMVASTATIN TREATMENT;
   VASCULAR REACTIVITY
AB Background: Vascular endothelial dysfunction, the hallmark of early atherosclerosis, is induced transiently by a high-fat meal. High doses of free L-arginine supplements reduce fasting endothelial dysfunction.
   Objective: We sought to determine the effects of a low dose of a sustained-release (SR) L-arginine supplement on postprandial endothelial function in healthy overweight adults with cardiometabolic risk factors and to investigate whether this effect may vary by baseline arginine status.
   Methods: In a randomized, double-blind, 2-period crossover, placebo-controlled trial (4-wk treatment, 4-wk washout), we compared the effects of 1.5 g SR-L-arginine 3 times/d (4.5 g/d) with placebo in 33 healthy overweight adults [body mass index (BMI, in kg/m(2)): 25 to >30] with the hypertriglyceridemic waist (HTW) phenotype [plasma triglycerides > 150 mg/dL; waist circumference > 94 cm (men) or > 80 cm (women)]. The main outcome variable tested was postprandial endothelial function after a high fat meal (900 kcal), as evaluated by use of flow-mediated dilation (FMD) and Framingham reactive hyperemia index (fRHI), after each treatment. By use of subgroup analysis, we determined whether the effect was related to the baseline plasma arginine concentration.
   Results: In the total population, the effects of SR-arginine supplementation on postprandial endothelial function were mixed and largely varied with baseline fasting arginine concentration (P-interaction < 0.05). In the lower half of the population (below the median of 78.2 mu mol arginine/L plasma), but not the upper half, SR-arginine supplementation attenuated the postprandial decrease in both FMD (29% decrease with SR-arginine compared with 50% decrease with placebo) and fRHI (5% increase with SR-arginine compared with 49% decrease with placebo), resulting in significantly higher mean +/- SEM values with SR-arginine (FMD: 4.0% +/- 0.40%; fRHI: 0.41 +/- 0.069) than placebo (FMD: 2.9% +/- 0.31%; fRHI: 0.21 +/- 0.060) at the end of the postprandial period (P < 0.05).
   Conclusions: Supplementation with low-dose SR-arginine alleviates postprandial endothelial dysfunction in healthy HTW adults when the baseline plasma arginine concentration is relatively low. The benefits of arginine supplementation may be linked to a lower ability to mobilize endogenous arginine for nitric oxide synthesis during a postprandial challenge. This trial was registered at clinicaltrials.gov as NCT02354794.
C1 [Deveaux, Ambre; Sadi, Samira; Hermier, Dominique; Mathe, Veronique; Fouillet, Helene; Huneau, Jean-Francois; Benamouzig, Robert; Mariotti, Francois] Univ Paris Saclay, INRA, AgroParisTech, UMR Physiol Nutr & Comportement Alimentaire, Paris, France.
   [Pham, Isabelle] Jean Verdier Hosp, Assistance Publ Hop Paris, Dept Physiol & Funct Invest, Bondy, France.
   [West, Sheila G.] Penn State Univ, Dept Nutr Sci, University Pk, PA 16802 USA.
   [West, Sheila G.] Penn State Univ, Dept Biobehav Hlth, University Pk, PA 16802 USA.
   [Andre, Etienne; Lantoine-Adam, Frederique; Bunouf, Pierre] Inst Rech Pierre Fabre, Boulogne, France.
C3 Universite Paris Saclay; AgroParisTech; INRAE; Assistance Publique
   Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire
   Saint-Louis - APHP; Hopital Universitaire Jean-Verdier - APHP;
   Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Behrend; Pennsylvania State
   University - University Park; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); Pennsylvania State University; Pennsylvania State
   University - University Park; Penn State Behrend
RP Mariotti, F (corresponding author), Univ Paris Saclay, INRA, AgroParisTech, UMR Physiol Nutr & Comportement Alimentaire, Paris, France.
EM francois.mariotti@agroparistech.fr
RI BENAMOUZIG, Robert/W-8067-2019; Mariotti, Francois/F-9651-2017;
   Fouillet, Helene/K-7314-2012
OI Mariotti, Francois/0000-0002-4516-3853; West,
   Sheila/0000-0003-3488-8768; Fouillet, Helene/0000-0003-3932-251X;
   BENAMOUZIG, ROBERT/0000-0003-1952-6830
FU Pierre Fabre Research Institute
FX Supported by a grant from Pierre Fabre Research Institute.
CR Amato MC, 2010, DIABETES CARE, V33, P920, DOI 10.2337/dc09-1825
   Avogaro A, 2003, DIABETES, V52, P795, DOI 10.2337/diabetes.52.3.795
   Ayer JG, 2010, OBESITY, V18, P945, DOI 10.1038/oby.2009.331
   Bai YY, 2009, AM J CLIN NUTR, V89, P77, DOI 10.3945/ajcn.2008.26544
   Ball RO, 2007, J NUTR, V137, p1626S, DOI 10.1093/jn/137.6.1626S
   Benjamin EJ, 2004, CIRCULATION, V109, P613, DOI 10.1161/01.CIR.0000112565.60887.1E
   Bode-Böger SM, 2006, EUR J CLIN PHARMACOL, V62, P91, DOI 10.1007/s00228-005-0004-z
   Böger GI, 2007, J AM COLL CARDIOL, V49, P2274, DOI 10.1016/j.jacc.2007.02.051
   Bonetti PO, 2004, J AM COLL CARDIOL, V44, P2137, DOI 10.1016/j.jacc.2004.08.062
   Borucki K, 2009, ATHEROSCLEROSIS, V205, P251, DOI 10.1016/j.atherosclerosis.2008.10.026
   Breuillard C, 2012, CLIN NUTR, V31, P415, DOI 10.1016/j.clnu.2011.11.012
   Burdge GC, 2005, BRIT J NUTR, V93, P3, DOI 10.1079/BJN20041282
   CASTILLO L, 1993, P NATL ACAD SCI USA, V90, P193, DOI 10.1073/pnas.90.1.193
   Ceriello A, 2004, DIABETES, V53, P701, DOI 10.2337/diabetes.53.3.701
   Ceriello A, 2002, CIRCULATION, V106, P1211, DOI 10.1161/01.CIR.0000027569.76671.A8
   Chowienczyk PJ, 1999, J AM COLL CARDIOL, V34, P2007, DOI 10.1016/S0735-1097(99)00441-6
   Deveaux A, 2016, J NUTR, V146, P1322, DOI 10.3945/jn.116.231910
   Ferreira AC, 2004, CIRCULATION, V110, P3599, DOI 10.1161/01.CIR.0000148820.55611.6B
   Gemignani V, 2008, ULTRASOUND MED BIOL, V34, P385, DOI 10.1016/j.ultrasmedbio.2007.08.006
   Hall WL, 2008, J NUTR, V138, P287, DOI 10.1093/jn/138.2.287
   Hamburg NM, 2008, CIRCULATION, V117, P2467, DOI 10.1161/CIRCULATIONAHA.107.748574
   Hamburg NM, 2009, TRENDS CARDIOVAS MED, V19, P6, DOI 10.1016/j.tcm.2009.03.001
   Haque MN, 2012, J DAIRY SCI, V95, P5876, DOI 10.3168/jds.2011-5230
   Herieka M, 2014, MOL NUTR FOOD RES, V58, P136, DOI 10.1002/mnfr.201300104
   International Physical Activity Questionnaire website, 2005, GUID DAT PROC AN INT
   Jegatheesan P, 2015, J NUTR, V145, P2273, DOI 10.3945/jn.115.218982
   Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213
   Lefèbvre P, 1998, DIABETIC MED, V15, pS63, DOI 10.1002/(SICI)1096-9136(1998120)15:4+<S63::AID-DIA737>3.3.CO;2-Z
   Lin CC, 2008, INT J CARDIOL, V127, P337, DOI 10.1016/j.ijcard.2007.06.013
   Luiking YC, 2015, CLIN SCI, V128, P57, DOI 10.1042/CS20140343
   Magné J, 2009, NITRIC OXIDE-BIOL CH, V21, P37, DOI 10.1016/j.niox.2009.04.003
   Mah E, 2012, NUTR RES, V32, P727, DOI 10.1016/j.nutres.2012.08.002
   Mah E, 2011, J NUTR, V141, P1961, DOI 10.3945/jn.111.144592
   Marchesi S, 2001, J CLIN PHARM THER, V26, P343, DOI 10.1046/j.1365-2710.2001.00362.x
   Mariotti F, 2013, AM J CLIN NUTR, V97, P972, DOI 10.3945/ajcn.112.048025
   Maxwell AJ, 2002, J AM COLL CARDIOL, V39, P37, DOI 10.1016/S0735-1097(01)01708-9
   McCrea CE, 2012, VASC MED, V17, P29, DOI 10.1177/1358863X11433188
   Moncada S, 2006, BRIT J PHARMACOL, V147, pS193, DOI 10.1038/sj.bjp.0706458
   Morris CR, 2000, BRIT J HAEMATOL, V111, P498, DOI 10.1046/j.1365-2141.2000.02403.x
   Napoli C, 2006, NITRIC OXIDE-BIOL CH, V15, P265, DOI 10.1016/j.niox.2006.03.011
   Nappo F, 2002, J AM COLL CARDIOL, V39, P1145, DOI 10.1016/S0735-1097(02)01741-2
   Neri S, 2005, CLIN THER, V27, P1764, DOI 10.1016/j.clinthera.2005.11.006
   Pfeuffer M, 2011, J AM COLL NUTR, V30, P19, DOI 10.1080/07315724.2011.10719940
   Preli RB, 2002, ATHEROSCLEROSIS, V162, P1, DOI 10.1016/S0021-9150(01)00717-1
   Siasos G, 2008, INT J CARDIOL, V126, P394, DOI 10.1016/j.ijcard.2007.04.057
   Siekmeier R, 2008, J CARDIOVASC PHARM T, V13, P279, DOI 10.1177/1074248408326488
   Siervo M, 2011, J HYPERTENS, V29, P1515, DOI 10.1097/HJH.0b013e3283487806
   Tousoulis D, 2012, CURR VASC PHARMACOL, V10, P4, DOI 10.2174/157016112798829760
   van de Poll MCG, 2004, AM J CLIN NUTR, V79, P185
   van Oostrom AJHHM, 2004, ATHEROSCLEROSIS, V177, P175, DOI 10.1016/j.atherosclerosis.2004.07.004
   Vincent Michelle A, 2003, Curr Diab Rep, V3, P279, DOI 10.1007/s11892-003-0018-9
   VISEK WJ, 1986, J NUTR, V116, P36, DOI 10.1093/jn/116.1.36
   Vogel RA, 1997, AM J CARDIOL, V79, P350, DOI 10.1016/S0002-9149(96)00760-6
   West SG, 2005, DIABETOLOGIA, V48, P113, DOI 10.1007/s00125-004-1600-7
   West SG, 2004, DIABETOLOGIA, V47, P1625, DOI 10.1007/s00125-004-1502-8
   Westphal S, 2006, ATHEROSCLEROSIS, V185, P313, DOI 10.1016/j.atherosclerosis.2005.06.004
   Wilkinson IB, 2000, J PHYSIOL-LONDON, V525, P263, DOI 10.1111/j.1469-7793.2000.t01-1-00263.x
   Yang ZH, 2006, CLIN MED RES, V4, P53, DOI 10.3121/cmr.4.1.53
NR 58
TC 27
Z9 28
U1 0
U2 9
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD JUL
PY 2016
VL 146
IS 7
BP 1330
EP 1340
DI 10.3945/jn.115.227959
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DQ7IL
UT WOS:000379380100007
PM 27281800
OA Bronze
DA 2025-06-11
ER

PT J
AU Ota, T
   Gayet, C
   Ginsberg, HN
AF Ota, Tsuguhito
   Gayet, Constance
   Ginsberg, Henry N.
TI Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic
   endoplasmic reticulum stress in rodents
SO JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
ID TRIGLYCERIDE TRANSFER PROTEIN; INSULIN-RESISTANCE; FATTY-ACIDS;
   INTRACELLULAR DEGRADATION; METABOLIC SYNDROME; ER STRESS; SODIUM
   4-PHENYLBUTYRATE; SELECTIVE-INHIBITION; B LIPOPROTEINS; LIVER-INJURY
AB ER stress can cause hepatic insulin resistance and steatosis. Increased VLDL secretion could protect the liver from ER stress-induced steatosis, but the effect of lipid-induced ER stress on the secretion of VLDL is unknown. To determine the effect of lipids on hepatic ER stress and VLDL secretion, we treated McA-RH7777 liver cells with free fatty acids. Prolonged exposure increased cell triglycerides, induced steatosis, and increased ER stress. Effects on apoB100 secretion, which is required for VLDL assembly, were parabolic, with moderate free fatty acid exposure increasing apoB100 secretion, while greater lipid loading inhibited apoB100 secretion. This decreased secretion at higher lipid levels was due to increased protein degradation through both proteasomal and nonproteasomal pathways and was dependent on the induction of ER stress. These findings were supported in vivo, where intravenous infusion of oleic acid (OA) in mice increased ER stress in a duration-dependent manner. apoB secretion was again parabolic, stimulated by moderate, but not prolonged, OA infusion. Inhibition of ER stress was able to restore OA-stimulated apoB secretion after prolonged OA infusion. These results suggest that excessive ER stress in response to increased hepatic lipids may decrease the ability of the liver to secrete triglycerides by limiting apoB secretion, potentially worsening steatosis.
C1 [Ota, Tsuguhito; Gayet, Constance; Ginsberg, Henry N.] Columbia Univ Coll Phys & Surg, Dept Med, New York, NY 10032 USA.
C3 Columbia University
RP Ginsberg, HN (corresponding author), Columbia Univ Coll Phys & Surg, Dept Med, PH 10-305,630 W 168th St, New York, NY 10032 USA.
EM hng1@columbia.edu
FU NHLBI NIH HHS [R01 HL073030, R01 HL055638] Funding Source: Medline
CR Adiels M, 2006, DIABETOLOGIA, V49, P755, DOI 10.1007/s00125-005-0125-z
   Avramoglu RK, 2003, FRONT BIOSCI, V8, pD464, DOI 10.2741/1022
   BARR J E, 1979, Pharmacology Biochemistry and Behavior, V11, P115, DOI 10.1016/0091-3057(79)90307-1
   Borradaile NM, 2006, MOL BIOL CELL, V17, P770, DOI 10.1091/mbc.E05-08-0742
   BOURGEOIS CS, 1995, AM J PHYSIOL-ENDOC M, V269, pE208, DOI 10.1152/ajpendo.1995.269.2.E208
   Browning JD, 2004, HEPATOLOGY, V40, P1387, DOI 10.1002/hep.20466
   Burrows JAJ, 2000, P NATL ACAD SCI USA, V97, P1796, DOI 10.1073/pnas.97.4.1796
   Calfon M, 2002, NATURE, V415, P92, DOI 10.1038/415092a
   Cnop M, 2007, J BIOL CHEM, V282, P3989, DOI 10.1074/jbc.M607627200
   Cohen FE, 2003, NATURE, V426, P905, DOI 10.1038/nature02265
   DIXON JL, 1991, J BIOL CHEM, V266, P5080
   Fisher EA, 2002, J BIOL CHEM, V277, P17377, DOI 10.1074/jbc.R100068200
   Fisher EA, 2001, J BIOL CHEM, V276, P27855, DOI 10.1074/jbc.M008885200
   Fisher EA, 1997, J BIOL CHEM, V272, P20427, DOI 10.1074/jbc.272.33.20427
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   Ford ES, 2004, DIABETES CARE, V27, P2444, DOI 10.2337/diacare.27.10.2444
   GAULL G, 1974, J PEDIATR-US, V84, P381, DOI 10.1016/S0022-3476(74)80721-3
   Ginsberg HN, 2005, ARCH MED RES, V36, P232, DOI 10.1016/j.arcmed.2005.01.005
   Gulsen M, 2005, J GASTROEN HEPATOL, V20, P1448, DOI 10.1111/j.1440-1746.2005.03891.x
   Harding HP, 1999, NATURE, V397, P271, DOI 10.1038/16729
   Harding HP, 2000, MOL CELL, V6, P1099, DOI 10.1016/S1097-2765(00)00108-8
   Harding HP, 2002, ANNU REV CELL DEV BI, V18, P575, DOI 10.1146/annurev.cellbio.18.011402.160624
   Ingram MF, 1996, J LIPID RES, V37, P2202
   Karaskov E, 2006, ENDOCRINOLOGY, V147, P3398, DOI 10.1210/en.2005-1494
   Kaufman RJ, 2002, NAT REV MOL CELL BIO, V3, P411, DOI 10.1038/nrm829
   Lee JN, 2006, J BIOL CHEM, V281, P39308, DOI 10.1074/jbc.M608999200
   Lewis G F, 1999, Curr Opin Lipidol, V10, P475, DOI 10.1097/00041433-199910000-00013
   LEWIS GF, 1993, DIABETES, V42, P833, DOI 10.2337/diabetes.42.6.833
   Liang JS, 2001, J BIOL CHEM, V276, P28606, DOI 10.1074/jbc.M100294200
   Liao W, 2003, J LIPID RES, V44, P978, DOI 10.1194/jlr.M300020-JLR200
   Macri J, 1997, ARTERIOSCL THROM VAS, V17, P2982, DOI 10.1161/01.ATV.17.11.2982
   Malhi H, 2006, J BIOL CHEM, V281, P12093, DOI 10.1074/jbc.M510660200
   Malmstrom R, 1997, ARTERIOSCL THROM VAS, V17, P1454, DOI 10.1161/01.ATV.17.7.1454
   Malmstrom R, 1997, DIABETOLOGIA, V40, P454, DOI 10.1007/s001250050700
   Marceau P, 1999, J CLIN ENDOCR METAB, V84, P1513, DOI 10.1210/jc.84.5.1513
   Marciniak SJ, 2006, PHYSIOL REV, V86, P1133, DOI 10.1152/physrev.00015.2006
   McGuinness MC, 2001, MOL GENET METAB, V74, P256, DOI 10.1006/mgme.2001.3239
   Mori K, 2000, CELL, V101, P451, DOI 10.1016/S0092-8674(00)80855-7
   Morris JA, 1997, J BIOL CHEM, V272, P4327, DOI 10.1074/jbc.272.7.4327
   Nakatani Y, 2005, J BIOL CHEM, V280, P847, DOI 10.1074/jbc.M411860200
   Nakatani Y, 2004, J BIOL CHEM, V279, P45803, DOI 10.1074/jbc.M406963200
   Neuschwander-Tetri BA, 2007, CURR OPIN GASTROEN, V23, P193, DOI 10.1097/MOG.0b013e32801421a9
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Olofsson SO, 2000, TRENDS CARDIOVAS MED, V10, P338, DOI 10.1016/S1050-1738(01)00071-8
   OTWAY S, 1967, J PHYSIOL-LONDON, V190, P321, DOI 10.1113/jphysiol.1967.sp008211
   Oyadomari S, 2006, CELL, V126, P727, DOI 10.1016/j.cell.2006.06.051
   Ozawa K, 2005, DIABETES, V54, P657, DOI 10.2337/diabetes.54.3.657
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Pagano G, 2002, HEPATOLOGY, V35, P367, DOI 10.1053/jhep.2002.30690
   Pan M, 2000, J BIOL CHEM, V275, P27399
   Pan MH, 2004, J CLIN INVEST, V113, P1277, DOI 10.1172/JCI200419197
   Qiu W, 2005, ARTERIOSCL THROM VAS, V25, P571, DOI 10.1161/01.ATV.0000154142.61859.94
   Qiu W, 2006, J LIPID RES, V47, P1749, DOI 10.1194/jlr.M500363-JLR200
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Rubenstein RC, 1997, J CLIN INVEST, V100, P2457, DOI 10.1172/JCI119788
   SAKATA N, 1993, J BIOL CHEM, V268, P22967
   SCANU ANGELO M., 1965, ADVANCE LIPID RES, V3, P63
   Shelness GS, 1999, J NUTR, V129, p456S, DOI 10.1093/jn/129.2.456S
   Shenkman M, 2007, BIOCHEM J, V404, P509, DOI 10.1042/BJ20061854
   Siri P, 2001, J BIOL CHEM, V276, P46064, DOI 10.1074/jbc.M108909200
   SMITH SG, 1974, METHODS NARCOTICS RE, P3
   SPARKS JD, 1994, BBA-LIPID LIPID MET, V1215, P9, DOI 10.1016/0005-2760(94)90088-4
   Sparks JD, 1997, BBA-LIPID LIPID MET, V1347, P51, DOI 10.1016/S0005-2760(97)00050-7
   Taghibiglou C, 2000, J BIOL CHEM, V275, P8416, DOI 10.1074/jbc.275.12.8416
   Utzschneider KM, 2006, J CLIN ENDOCR METAB, V91, P4753, DOI 10.1210/jc.2006-0587
   Vilatoba M, 2005, SURGERY, V138, P342, DOI 10.1016/j.surg.2005.04.019
   Wang D, 2006, ENDOCRINOLOGY, V147, P943, DOI 10.1210/en.2005-0570
   Wang HY, 2005, J CELL SCI, V118, P3905, DOI 10.1242/jcs.02513
   Wei YR, 2006, AM J PHYSIOL-ENDOC M, V291, pE275, DOI 10.1152/ajpendo.00644.2005
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Werstuck GH, 2001, J CLIN INVEST, V107, P1263, DOI 10.1172/JCI11596
   Yao ZM, 1997, J LIPID RES, V38, P1937
   Yoshida H, 2001, CELL, V107, P881, DOI 10.1016/S0092-8674(01)00611-0
   Zhang YL, 2004, J BIOL CHEM, V279, P19362, DOI 10.1074/jbc.M400220200
   Zhou MY, 1998, J BIOL CHEM, V273, P24649, DOI 10.1074/jbc.273.38.24649
NR 75
TC 303
Z9 350
U1 2
U2 36
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA
SN 0021-9738
EI 1558-8238
J9 J CLIN INVEST
JI J. Clin. Invest.
PD JAN
PY 2008
VL 118
IS 1
BP 316
EP 332
DI 10.1172/JCI32752
PG 17
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 248AE
UT WOS:000252122900032
PM 18060040
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Bergman, M
   Lundholm, A
AF Bergman, Martin
   Lundholm, Amy
TI Mitigation of disease- and treatment-related risks in patients with
   psoriatic arthritis
SO ARTHRITIS RESEARCH & THERAPY
LA English
DT Review
DE Psoriatic arthritis; Disease-specific risks; Treatment-related risks;
   Psychological risks; Comorbidities; Quality of life; Risk; Review
ID ANTI-INTERLEUKIN-17A MONOCLONAL-ANTIBODY; PLACEBO-CONTROLLED TRIAL;
   QUALITY-OF-LIFE; DOUBLE-BLIND; ANKYLOSING-SPONDYLITIS;
   RHEUMATOID-ARTHRITIS; TREATMENT RECOMMENDATIONS; METABOLIC SYNDROME;
   SPONDYLOARTHRITIS; PREVALENCE
AB Psoriatic arthritis is a part of the family of diseases referred to as spondyloarthropathies, a diverse group of chronic inflammatory disorders with common clinical, radiographic, and genetic features. Peripheral arthritis is the most common symptom of psoriatic arthritis and patients also frequently experience involvement of the entheses, spine, skin, and nails. Due to the diverse clinical spectrum of disease severity, tissues affected, and associated comorbidities, the treatment of psoriatic arthritis can be challenging and it is necessary to mitigate risks associated with both the disease and its treatment. These risks include disease-specific, treatment-related, and psychological risks. Disease-specific risks include those associated with disease progression that can limit functional status and be mitigated through early diagnosis and initiation of treatment. Risks also arise from comorbidities that are associated with psoriatic arthritis such as cardiovascular disease, obesity, diabetes mellitus, and gastrointestinal inflammation. Patient outcomes can be affected by the treatment strategy employed and the pharmacologic agents administered. Additionally, it is important for physicians to be aware of risks specific to each therapeutic option. The impact of psoriatic arthritis is not limited to the skin and joints and it is common for patients to experience quality-of-life impairment. Patients are also more likely to have depression, anxiety, and alcoholism. This article reviews the many risks associated with psoriatic arthritis and provides guidance on mitigating these risks.
C1 [Bergman, Martin] Taylor Hosp, 8 Morton Ave,Suite 304, Ridley Pk, PA 19078 USA.
   [Lundholm, Amy] Lankenau Med Ctr, Wynnewood, PA USA.
C3 Lankenau Medical Center
RP Bergman, M (corresponding author), Taylor Hosp, 8 Morton Ave,Suite 304, Ridley Pk, PA 19078 USA.
EM mjbergman@prodigy.net
FU Novartis Pharmaceuticals Corporation
FX Technical assistance with editing and styling of the manuscript for
   submission was provided by Oxford PharmaGenesis Inc. and was funded by
   Novartis Pharmaceuticals Corporation.
CR Amherd-Hoekstra A, 2010, J DTSCH DERMATOL GES, V8, P332, DOI 10.1111/j.1610-0387.2009.07334.x
   Antoni C, 2005, ANN RHEUM DIS, V64, P1150, DOI 10.1136/ard.2004.032268
   Archier E, 2012, J EUR ACAD DERMATOL, V26, P22, DOI 10.1111/j.1468-3083.2012.04520.x
   Berends MAM, 2006, ALIMENT PHARM THERAP, V24, P805, DOI 10.1111/j.1365-2036.2006.03047.x
   Betteridge N, 2016, J EUR ACAD DERMATOL, V30, P576, DOI 10.1111/jdv.13306
   Blum MA, 2011, CLIN THER, V33, P901, DOI 10.1016/j.clinthera.2011.06.001
   Bostoen J, 2014, J EUR ACAD DERMATOL, V28, P507, DOI 10.1111/jdv.12071
   Brockbank JE, 2005, ANN RHEUM DIS, V64, P188, DOI 10.1136/ard.2003.018184
   Coates LC, 2010, ANN RHEUM DIS, V69, P48, DOI 10.1136/ard.2008.102053
   Coates LC, 2016, ARTHRITIS RHEUMATOL, V68, P1060, DOI 10.1002/art.39573
   Coates LC, 2015, LANCET, V386, P2489, DOI 10.1016/S0140-6736(15)00347-5
   Collantes E, 2007, RHEUMATOLOGY, V46, P1309, DOI 10.1093/rheumatology/kem084
   Eder L, 2015, ANN RHEUM DIS, V74, P813, DOI 10.1136/annrheumdis-2013-204448
   Eder L, 2014, EXPERT REV CLIN IMMU, V10, P763, DOI 10.1586/1744666X.2014.905741
   El Miedany Y, 2014, CURR RHEUMATOL REV, V10, P87, DOI 10.2174/1573397110666140301000430
   Elewaut D, 2009, RHEUMATOLOGY, V48, P1029, DOI 10.1093/rheumatology/kep146
   Elyoussfi S, 2016, RHEUMATOL INT, V36, P603, DOI 10.1007/s00296-016-3436-0
   Gelfand JM, 2005, J AM ACAD DERMATOL, V53, P573, DOI 10.1016/j.jaad.2005.03.046
   Gezer O, 2014, INT J RHEUM DIS, DOI [10.1111/756-185X.12505, DOI 10.1111/756-185X.12505]
   Gladman DD, 2005, ANN RHEUM DIS, V64, P14, DOI 10.1136/ard.2004.032482
   Gladman DD, 2001, J RHEUMATOL, V28, P1045
   Glintborg B, 2013, ARTHRITIS RHEUM-US, V65, P1213, DOI 10.1002/art.37876
   Gossec L, 2012, ANN RHEUM DIS, V71, P4, DOI 10.1136/annrheumdis-2011-200350
   Haroon M, 2016, EXPERT REV CLIN IMMU, V12, P405, DOI 10.1586/1744666X.2016.1139453
   Haroon M, 2015, ANN RHEUM DIS, V74, P1045, DOI 10.1136/annrheumdis-2013-204858
   Haroon M, 2014, J RHEUMATOL, V41, P1357, DOI 10.3899/jrheum.140021
   Haroon NN, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2014-006634
   Horreau C, 2013, J EUR ACAD DERMATOL, V27, P12, DOI 10.1111/jdv.12163
   Jamnitski A, 2013, ANN RHEUM DIS, V72, P211, DOI 10.1136/annrheumdis-2011-201194
   Kang EJ, 2015, THER ADV CHRONIC DIS, V6, P194, DOI 10.1177/2040622315582354
   Kavanaugh A, 2014, ANN RHEUM DIS, V73, P1020, DOI 10.1136/annrheumdis-2013-205056
   Kavanaugh A, 2009, ARTHRITIS RHEUM-US, V60, P976, DOI 10.1002/art.24403
   Kingsley GH, 2012, RHEUMATOLOGY, V51, P1368, DOI 10.1093/rheumatology/kes001
   Labitigan M, 2014, ARTHRIT CARE RES, V66, P600, DOI 10.1002/acr.22185
   Lee Seina, 2010, P T, V35, P680
   Li WQ, 2013, ANN RHEUM DIS, V72, P1200, DOI 10.1136/annrheumdis-2012-202143
   Liu JT, 2014, WORLD J ORTHOP, V5, P537, DOI 10.5312/wjo.v5.i4.537
   Londono J, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2015-009092
   López-González R, 2015, CLIN EXP RHEUMATOL, V33, P559
   McDonough E, 2014, J RHEUMATOL, V41, P887, DOI 10.3899/jrheum.130797
   McInnes IB, 2015, LANCET, V386, P1137, DOI 10.1016/S0140-6736(15)61134-5
   McInnes IB, 2014, ANN RHEUM DIS, V73, P349, DOI 10.1136/annrheumdis-2012-202646
   McInnes IB, 2013, LANCET, V382, P780, DOI 10.1016/S0140-6736(13)60594-2
   Mease PJ, 2014, ANN RHEUM DIS, V73, P48, DOI 10.1136/annrheumdis-2013-203696
   Mease P, 2011, ARTHRITIS RHEUM-US, V63, P939, DOI 10.1002/art.30176
   Mease PJ, 2015, RMD OPEN, V1, DOI 10.1136/rmdopen-2015-000181
   Mease PJ, 2015, NEW ENGL J MED, V373, P1329, DOI 10.1056/NEJMoa1412679
   Mease PJ, 2013, J AM ACAD DERMATOL, V69, P729, DOI 10.1016/j.jaad.2013.07.023
   Mease PJ, 2012, NAT REV RHEUMATOL, V8, P251, DOI 10.1038/nrrheum.2012.56
   Mease PJ, 2004, ARTHRITIS RHEUM-US, V50, P2264, DOI 10.1002/art.20335
   Mease PJ, 2005, ARTHRITIS RHEUM-US, V52, P3279, DOI 10.1002/art.21306
   Menter A, 2010, J AM ACAD DERMATOL, V62, P114, DOI 10.1016/j.jaad.2009.08.026
   Ogdie A, 2015, CURR OPIN RHEUMATOL, V27, P118, DOI 10.1097/BOR.0000000000000152
   Ritchlin C, 2014, ANN RHEUM DIS, V73, P990, DOI 10.1136/annrheumdis-2013-204655
   Rohekar S, 2015, J RHEUMATOL, V42, P654, DOI 10.3899/jrheum.141000
   Rojas-Vargas M, 2009, RHEUMATOLOGY, V48, P404, DOI 10.1093/rheumatology/ken506
   Rosen CF, 2012, RHEUMATOLOGY, V51, P571, DOI 10.1093/rheumatology/ker365
   Saber TP, 2010, ARTHRITIS RES THER, V12, DOI 10.1186/ar3021
   Sanmartí R, 2009, ARTHRITIS RES THER, V11, DOI 10.1186/ar2802
   Schett G, 2011, ARTHRITIS RES THER, V13, DOI [10.1186/ar3095, 10.1186/1478-6354-13-S1-S4]
   Schoels MM, 2014, ANN RHEUM DIS, V73, P238, DOI 10.1136/annrheumdis-2013-203860
   Singh JA, 2009, J RHEUMATOL, V36, P1012, DOI 10.3899/jrheum.081015
   Smolen JS, 2014, ANN RHEUM DIS, V73, P6, DOI 10.1136/annrheumdis-2013-203419
   Solomon DH, 2010, ANN RHEUM DIS, V69, P2114, DOI 10.1136/ard.2009.125476
   Soltani-Arabshahi R, 2010, ARCH DERMATOL, V146, P721, DOI 10.1001/archdermatol.2010.141
   Taylor W, 2006, ARTHRITIS RHEUM, V54, P2665, DOI 10.1002/art.21972
   Veale DJ, 2015, RMD OPEN, V1, DOI 10.1136/rmdopen-2014-000025
   Versini M, 2014, AUTOIMMUN REV, V13, P981, DOI 10.1016/j.autrev.2014.07.001
   Wendling D, 2015, EXPERT REV CLIN IMMU, V11, P691, DOI 10.1586/1744666X.2015.1039514
   Zarco P, 2015, REUMATOL CLIN, V11, P83, DOI 10.1016/j.reuma.2014.04.003
   Zhu TY, 2008, RHEUMATOLOGY, V47, P1422, DOI 10.1093/rheumatology/ken287
   Zhu TY, 2012, INT J RHEUMATOL, V2012, DOI 10.1155/2012/714321
   Zisapel M, 2015, J RHEUMATOL, V42, P73, DOI 10.3899/jrheum.140685
   Zochling J, 2010, BEST PRACT RES CL RH, V24, P747, DOI 10.1016/j.berh.2011.02.002
NR 74
TC 18
Z9 18
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1478-6354
EI 1478-6362
J9 ARTHRITIS RES THER
JI Arthritis Res. Ther.
PD MAR 20
PY 2017
VL 19
AR 63
DI 10.1186/s13075-017-1265-5
PG 8
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA EO4KY
UT WOS:000396665000005
PM 28320454
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Park, SJ
   Park, JJ
   Choi, DJ
   Chun, EJ
   Choi, SI
   Kim, SM
   Jang, SY
   Ahn, S
   Choe, YH
AF Park, Sung-Ji
   Park, Jin Joo
   Choi, Dong-Ju
   Chun, Eun Ju
   Choi, Sang Il
   Kim, Sung Mok
   Jang, Shin Yi
   Ahn, Soyeon
   Choe, Yeon Hyeon
TI Understanding of chest pain in microvascular disease proved by cardiac
   magnetic resonance image (UMPIRE): study protocol for a randomized
   controlled trial
SO TRIALS
LA English
DT Article
DE Microvascular angina; PDE-5 inhibitors; Cardiac MRI
ID NORMAL CORONARY ANGIOGRAMS; LEFT-VENTRICULAR FUNCTION; SYNDROME-X;
   CLINICAL CHARACTERISTICS; ENDOTHELIAL DYSFUNCTION; MYOCARDIAL-ISCHEMIA;
   SILDENAFIL; ANGINA; VIAGRA; HYPERTENSION
AB Background: Microvascular angina (MVA) is characterized by anginal chest pain, an abnormal stress test, and normal coronary arteries on coronary angiography. Although the exact pathogenesis remains unclear, endothelial dysfunction is a contributing factor. To date, there exists no specific therapy for this disease. Phosphodiesterase-5 inhibitor improves the endothelial function and subsequently microvascular circulation. The aim of this study is to identify whether udenafil offers benefits in the treatment of MVA in female patients, who have a perfusion defect in their cardiac magnetic resonance image (CMR), but normal coronary arteries.
   Methods/Design: The 'Understanding of Chest Pain in Microvascular Disease Proved by Cardiac Magnetic Resonance Image: (UMPIRE)' trial is a multicenter, prospective, randomized, placebo controlled trial, designed to evaluate the effect of udenafil on myocardial ischemia and symptoms in female patients with MVA. The myocardial ischemia will be quantified by myocardial stress perfusion defect in CMR. A total of 80 patients with proven perfusion defect in adenosine-stress CMR will be randomly assigned to either the udenafil treatment group (daily dose of 100 mg) or the placebo group for three months. The primary endpoint is >25% improvement in perfusion defect size in adenosine-stress CMR from baseline. The secondary endpoints include <25% improvement in perfusion defect size, chest pain frequency, ST depression in stress test, Duke score in stress test, quality of life (QoL) assessment by SF-36 questionnaire, sexual dysfunction assessment by BISF-W (Brief Index of Sexual Functioning for Women) self-assessment questionnaire, and biomarkers for endothelial function.
   Discussion: The UMPIRE trial is the first randomized controlled trial to evaluate the efficacy of udenafil in female MVA patients. If udenafil demonstrates cardioprotective effects, it may provide a novel therapeutic option to reduce myocardial ischemia and improve cardiac function in female MVA patients.
C1 [Park, Sung-Ji; Kim, Sung Mok; Jang, Shin Yi; Choe, Yeon Hyeon] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Cardiovasc Imaging Ctr,Stroke Inst, Seoul 135710, South Korea.
   [Park, Jin Joo; Choi, Dong-Ju] Seoul Natl Univ, Coll Med, Bundang Hosp, Ctr Cardiovasc, Songnam 463707, Gyeonggi Do, South Korea.
   [Chun, Eun Ju; Choi, Sang Il] Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Radiol, Songnam 463707, Gyeonggi Do, South Korea.
   [Ahn, Soyeon] Seoul Natl Univ, Bundang Hosp, Med Res Collaborating Ctr, Songnam 463707, Gyeonggi Do, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Seoul National
   University (SNU); Seoul National University (SNU); Seoul National
   University (SNU)
RP Choi, DJ (corresponding author), Seoul Natl Univ, Coll Med, Bundang Hosp, Ctr Cardiovasc, Gumiro 166, Songnam 463707, Gyeonggi Do, South Korea.
EM djchoi@snu.ac.kr
RI Choi, Sang-Il/AGR-1133-2022; Choe, Yeon/F-1422-2010; Ahn,
   Soyeon/NES-1216-2025; Choi, Dong-Ju/J-5686-2012; kim,
   sungmok/D-6143-2017
CR Arthur HM, 2012, CAN J CARDIOL, V28, pS42, DOI 10.1016/j.cjca.2011.09.006
   BUGIARDINI R, 1989, AM J CARDIOL, V63, P286, DOI 10.1016/0002-9149(89)90332-9
   Bugiardini R, 2006, ARCH INTERN MED, V166, P1391, DOI 10.1001/archinte.166.13.1391
   Cannon RO, 2009, J AM COLL CARDIOL, V54, P877, DOI 10.1016/j.jacc.2009.03.080
   CANNON RO, 1994, NEW ENGL J MED, V330, P1411, DOI 10.1056/NEJM199405193302003
   Chen YJ, 2000, AM J PHYSIOL-HEART C, V279, pH2319, DOI 10.1152/ajpheart.2000.279.5.H2319
   Félétou M, 2006, AM J PHYSIOL-HEART C, V291, pH985, DOI 10.1152/ajpheart.00292.2006
   Halcox JPJ, 2002, J AM COLL CARDIOL, V40, P1232, DOI 10.1016/S0735-1097(02)02139-3
   Herrmann HC, 2000, NEW ENGL J MED, V342, P1622, DOI 10.1056/NEJM200006013422201
   Hirata K, 2005, AM J CARDIOL, V96, P1436, DOI 10.1016/j.amjcard.2005.06.091
   KASKI JC, 1995, J AM COLL CARDIOL, V25, P807, DOI 10.1016/0735-1097(94)00507-M
   KASKI JC, 1994, J AM COLL CARDIOL, V23, P652, DOI 10.1016/0735-1097(94)90750-1
   Lanza GA, 1999, AM J CARDIOL, V84, P854, DOI 10.1016/S0002-9149(99)00450-6
   Lanza GA, 2010, CIRCULATION, V121, P2317, DOI 10.1161/CIRCULATIONAHA.109.900191
   NABEL EG, 1988, CIRCULATION, V77, P43, DOI 10.1161/01.CIR.77.1.43
   Ockaili R, 2002, AM J PHYSIOL-HEART C, V283, pH1263, DOI 10.1152/ajpheart.00324.2002
   Paick JS, 2008, J SEX MED, V5, P946, DOI 10.1111/j.1743-6109.2007.00723.x
   Pérez NG, 2007, HYPERTENSION, V49, P1095, DOI 10.1161/HYPERTENSIONAHA.107.087759
   Przyklenk K, 2001, J AM COLL CARDIOL, V37, P286, DOI 10.1016/S0735-1097(00)01049-4
   Radovits T, 2009, BRIT J PHARMACOL, V156, P909, DOI 10.1111/j.1476-5381.2008.00098.x
   Reffelmann T, 2003, CARDIOVASC RES, V59, P441, DOI 10.1016/S0008-6363(03)00435-8
   Salloum FN, 2008, AM J PHYSIOL-HEART C, V294, pH1398, DOI [10.1152/ajpheart.ajpheart.91438.2007, 10.1152/ajpheart.91438.2007]
   SHIMOKAWA H, 1988, INT J CARDIOL, V18, P331, DOI 10.1016/0167-5273(88)90052-6
   Taylor AJ, 2004, CIRCULATION, V109, P2080, DOI 10.1161/01.CIR.0000127812.62277.50
   Traverse JH, 2000, CIRCULATION, V102, P2997
   Wallis RM, 1999, AM J CARDIOL, V83, p3C
   Wilcox CS, 2005, AM J PHYSIOL-REG I, V289, pR913, DOI 10.1152/ajpregu.00250.2005
   Yaguas K, 2010, AM J NEPHROL, V31, P283, DOI 10.1159/000279307
NR 28
TC 6
Z9 6
U1 0
U2 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1745-6215
J9 TRIALS
JI Trials
PD AUG 26
PY 2014
VL 15
AR 333
DI 10.1186/1745-6215-15-333
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AO3FP
UT WOS:000341214900001
PM 25154607
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gohar, SM
   Dieset, I
   Steen, NE
   Morch, RH
   Iversen, TS
   Steen, VM
   Andreassen, OA
   Melle, I
AF Gohar, Sherif M.
   Dieset, Ingrid
   Steen, Nils Eiel
   Morch, Ragni H.
   Iversen, Trude S.
   Steen, Vidar M.
   Andreassen, Ole A.
   Melle, Ingrid
TI Association between serum lipid levels, osteoprotegerin and depressive
   symptomatology in psychotic disorders
SO EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
LA English
DT Article
DE Depression; Dyslipidemia; Schizophrenia; Cholesterol; Cytokines; Bipolar
ID LOW-DENSITY-LIPOPROTEIN; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   SCHIZOPHRENIA; SYMPTOMS; CHOLESTEROL; MORTALITY; SCALE; RISK;
   INFLAMMATION
AB Although the relationship between positive and negative symptoms of psychosis and dyslipidemia has been thoroughly investigated in recent studies, the potential link between depression and lipid status is still under-investigated. We here examined the association between lipid levels and depressive symptomatology in patients with psychotic disorders, in addition to their possible inflammatory associations. Participants (n = 652) with the following distribution: schizophrenia, schizophreniform and schizoaffective disorder (schizophrenia group, n = 344); bipolar I, II, NOS, and psychosis NOS (non-schizophrenia group, n = 308) were recruited consecutively from the Norwegian Thematically Organized Psychosis (TOP) Study. Clinical data were obtained by Positive and Negative Syndrome Scale (PANSS), and Calgary Depression Scale for Schizophrenia (CDSS). Blood samples were analyzed for total cholesterol (TC), low-density lipoprotein (LDL), triglyceride (TG), C-reactive protein (CRP), soluble tumor necrosis factor receptor 1(sTNF-R1), osteoprotegerin (OPG), and interleukin 1 receptor antagonist (IL-1Ra). After adjusting for age, gender, BMI, smoking, and dyslipidemia-inducing antipsychotics, TC and LDL scores showed significant associations with depression [beta = 0.13, p = 0.007; beta = 0.14, p = 0.007], and with two inflammatory markers: CRP [beta = 0.14, p = 0.007; beta = 0.16, p = 0.007] and OPG [beta = 0.14, p = 0.007; beta = 0.11, p = 0.007]. Total model variance was 17% for both analyses [F(12, 433) = 8.42, p < 0.001; F(12, 433) = 8.64, p < 0.001]. Current findings highlight a potential independent role of depression and inflammatory markers, CRP and OPG in specific, in the pathophysiology of dyslipidemia in psychotic disorders.
C1 [Gohar, Sherif M.; Dieset, Ingrid; Steen, Nils Eiel; Morch, Ragni H.; Iversen, Trude S.; Andreassen, Ole A.; Melle, Ingrid] Univ Oslo, KG Jebsen Ctr Psychosis Res, Inst Clin Med, NORMENT, Oslo, Norway.
   [Gohar, Sherif M.; Dieset, Ingrid; Steen, Nils Eiel; Morch, Ragni H.; Iversen, Trude S.; Andreassen, Ole A.; Melle, Ingrid] Oslo Univ Hosp, Ulleval Hosp, Div Mental Hlth & Addict, Psychosis Res Unit,TOP, Bldg 49,Kirkeveien 166, N-0424 Oslo, Norway.
   [Steen, Vidar M.] Univ Bergen, KG Jebsen Ctr Psychosis Res, Dept Clin Sci, NORMENT, Bergen, Norway.
   [Steen, Vidar M.] Haukeland Hosp, Ctr Med Genet & Mol Med, Dr Einar Martens Res Grp Biol Psychiat, Bergen, Norway.
   [Gohar, Sherif M.] Cairo Univ, Fac Med, Dept Psychiat, Cairo, Egypt.
C3 University of Oslo; University of Oslo; University of Bergen; University
   of Bergen; Haukeland University Hospital; Egyptian Knowledge Bank (EKB);
   Cairo University
RP Gohar, SM (corresponding author), Univ Oslo, KG Jebsen Ctr Psychosis Res, Inst Clin Med, NORMENT, Oslo, Norway.; Gohar, SM (corresponding author), Oslo Univ Hosp, Ulleval Hosp, Div Mental Hlth & Addict, Psychosis Res Unit,TOP, Bldg 49,Kirkeveien 166, N-0424 Oslo, Norway.; Gohar, SM (corresponding author), Cairo Univ, Fac Med, Dept Psychiat, Cairo, Egypt.
EM sherif.gohar@kasralainy.edu.eg; ingrid.dieset@medisin.uio.no;
   n.e.steen@medisin.uio.no; r.h.morch@medisin.uio.no;
   t.s.j.iversen@medisin.uio.no; vidar.martin.steen@helse-bergen.no;
   ole.andreassen@medisin.uio.no; ingrid.melle@medisin.uio.no
RI Melle, Ingrid/B-4858-2011; Gohar, Sherif/ABF-3812-2021; Andreassen,
   Ole/AAY-7531-2020; Steen, Nils Eiel/GRO-6284-2022
OI Gohar, Sherif/0000-0002-4420-5716
FU European Union [609020]; Research Council of Norway (Centres of
   Excellence funding scheme) [223273/F50]; Stiftelsen Kristian Gerhard
   Jebsen [SKGJ-MED-008]; Regional Health Authority South-Eastern Norway:
   "Regional Research Network Psychotic Disorders" [2014102]
FX The research leading to these results has received funding from the
   European Union Seventh Framework Programme (FP7-PEOPLE-2013-COFUND)
   under Grant agreement no. 609020-Scientia Fellows. In addition, the
   study was supported by grants from the Research Council of Norway to
   NORMENT CoE (Grant number 223273/F50, under the Centres of Excellence
   funding scheme), Stiftelsen Kristian Gerhard Jebsen (SKGJ-MED-008), and
   Regional Health Authority South-Eastern Norway: "Regional Research
   Network Psychotic Disorders" (2014102).
CR ADDINGTON D, 1994, SCHIZOPHR RES, V11, P239, DOI 10.1016/0920-9964(94)90017-5
   ADDINGTON D, 1990, SCHIZOPHR RES, V3, P247, DOI 10.1016/0920-9964(90)90005-R
   Akbaraly TN, 2009, DIABETES CARE, V32, P499, DOI 10.2337/dc08-1358
   Andreassen OA, 2013, AM J HUM GENET, V92, P197, DOI 10.1016/j.ajhg.2013.01.001
   Brown S, 2000, BRIT J PSYCHIAT, V177, P212, DOI 10.1192/bjp.177.3.212
   Capuron L, 2008, BIOL PSYCHIAT, V64, P896, DOI 10.1016/j.biopsych.2008.05.019
   Hert M, 2012, NAT REV ENDOCRINOL, V8, P114, DOI 10.1038/nrendo.2011.156
   Dieset I, 2012, SCHIZOPHR RES, V140, P169, DOI 10.1016/j.schres.2012.06.040
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   First MB., 2002, STRUCTURED CLIN INTE
   Gjerde PB, 2017, SCHIZOPHR RES
   Gonçalves P, 2015, EUR NEUROPSYCHOPHARM, V25, P1, DOI 10.1016/j.euroneuro.2014.11.008
   Grundy SM, 2004, ARTERIOSCLER THROMB
   Hope S, 2013, SCHIZOPHR RES, V145, P36, DOI 10.1016/j.schres.2012.12.023
   Hope S, 2011, J PSYCHIATR RES, V45, P1608, DOI 10.1016/j.jpsychires.2011.08.003
   Hope S, 2010, J PSYCHIATR NEUROSCI, V35, P304, DOI 10.1503/jpn.090088
   Kadoglou NPE, 2014, CLIN DRUG INVEST, V34, P165, DOI 10.1007/s40261-013-0157-y
   Kahl KG, 2012, EUR ARCH PSY CLIN N, V262, P313, DOI 10.1007/s00406-011-0277-4
   KAY SR, 1987, SCHIZOPHRENIA BULL, V13, P261, DOI 10.1093/schbul/13.2.261
   Köhler CA, 2017, ACTA PSYCHIAT SCAND, V135, P373, DOI 10.1111/acps.12698
   Laursen TM, 2014, ANNU REV CLIN PSYCHO, V10, P425, DOI 10.1146/annurev-clinpsy-032813-153657
   Leucht S, 2013, LANCET, V382, P951, DOI 10.1016/S0140-6736(13)60733-3
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Lütjohann D, 2004, STEROIDS, V69, P431, DOI 10.1016/j.steroids.2004.03.012
   Martinac M, 2014, ACTA CLIN CROAT, V53, P55
   Mezuk B, 2008, DIABETES CARE, V31, P2383, DOI 10.2337/dc08-0985
   Miller BJ, 2017, NEUROPSYCHOPHARMACOL, V42, P299, DOI 10.1038/npp.2016.211
   Misiak B, 2017, SCHIZOPHR RES, V190, P18, DOI 10.1016/j.schres.2017.03.031
   Morch RH, 2016, PSYCHONEUROENDOCRINO, V67, P189, DOI 10.1016/j.psyneuen.2016.02.011
   Nerhus M, 2016, SCHIZOPHR RES, V178, P44, DOI 10.1016/j.schres.2016.08.024
   Nybo M, 2008, EUR J ENDOCRINOL, V159, P603, DOI 10.1530/EJE-08-0554
   Oh ES, 2005, METABOLISM, V54, P49, DOI 10.1016/j.metabol.2004.08.005
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Parekh A, 2017, HEALTHCARE-BASEL, V5, DOI 10.3390/healthcare5010005
   Penninx BWJH, 2001, ARCH GEN PSYCHIAT, V58, P221, DOI 10.1001/archpsyc.58.3.221
   Persons JE, 2016, J AFFECT DISORDERS, V206, P55, DOI 10.1016/j.jad.2016.07.033
   Reine G, 2003, ACTA PSYCHIAT SCAND, V108, P297, DOI 10.1034/j.1600-0447.2003.00132.x
   Rethorst CD, 2014, J CLIN PSYCHIAT, V75, pE1428, DOI 10.4088/JCP.14m09009
   Saari K, 2004, ACTA PSYCHIAT SCAND, V110, P279, DOI 10.1111/j.1600-0447.2004.00358.x
   Sands JR, 1999, SCHIZOPHRENIA BULL, V25, P157, DOI 10.1093/oxfordjournals.schbul.a033362
   Siasos G, 2011, CURR PHARM DESIGN, V17, P4132, DOI 10.2174/138161211798764780
   Siris SG, 2000, AM J PSYCHIAT, V157, P1379, DOI 10.1176/appi.ajp.157.9.1379
   Skilton MR, 2007, BIOL PSYCHIAT, V62, P1251, DOI 10.1016/j.biopsych.2007.01.012
   Solberg DK, 2016, BMC PSYCHIATRY, V16, DOI 10.1186/s12888-016-1006-3
   Steen NE, 2017, WORLD J BIOL PSYCHIA, V18, P471, DOI 10.1080/15622975.2016.1245441
   Suttajit S, 2013, NEUROPSYCH DIS TREAT, V9, P941, DOI 10.2147/NDT.S47450
   Toffoli B, 2016, MEDIAT INFLAMM, V2016, DOI 10.1155/2016/6529728
   Tomasik J, 2016, SCHIZOPHR RES, V176, P3, DOI 10.1016/j.schres.2014.07.025
   Upthegrove R, 2014, SCHIZOPHR RES, V155, P101, DOI 10.1016/j.schres.2014.03.005
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Viinamäki H, 2009, ACTA PSYCHIAT SCAND, V120, P23, DOI 10.1111/j.1600-0447.2008.01333.x
   Wysokinski A, 2015, DIABETES METAB SYND, V9, P168, DOI 10.1016/j.dsx.2015.04.004
   Zisook S, 2007, AM J GERIAT PSYCHIAT, V15, P1005, DOI 10.1097/JGP.0b013e3180a725ec
NR 53
TC 18
Z9 18
U1 0
U2 5
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0940-1334
EI 1433-8491
J9 EUR ARCH PSY CLIN N
JI Eur. Arch. Psych. Clin. Neurosci.
PD OCT
PY 2019
VL 269
IS 7
BP 795
EP 802
DI 10.1007/s00406-018-0897-z
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA IW9JK
UT WOS:000485309400005
PM 29721726
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Seydi-Shirvani, S
   Rasmi, Y
   Seyyed-Mohammadzad, MH
   Khosravifar, F
AF Seydi-Shirvani, Sam
   Rasmi, Yousef
   Seyyed-Mohammadzad, Mir-Hossein
   Khosravifar, Fariba
TI Oxidative stress status in patients with cardiac syndrome X
SO SCIENCEASIA
LA English
DT Article
DE microvascular dysfunction; antioxidant; angina pectoris
ID NORMAL CORONARY-ARTERIES; ENDOTHELIAL DYSFUNCTION; ANTIOXIDANT STATUS;
   ANGINA-PECTORIS; FREE-RADICALS; DAMAGE; NEBIVOLOL; PROGNOSIS; DISEASES
AB Cardiac syndrome X (CSX) is characterized by chest pain, typical angina pectoris, abnormal exercise test result and normal coronary arteries. Microvascular dysfunction and enhanced oxidative stress are the mechanisms suspected to play an important role in the pathogenesis of CSX. Thus we aimed to evaluate the oxidative stress status of 28 patients with CSX (14 male/14 female, mean age 49.5 +/- 9.3 years) and 24 age- and gender-matched healthy controls (10 male/14 female, mean age 45.6 +/- 5.7 years). Blood samples were drawn for measurement of malodialdehyde (MDA), as a marker of lipid peroxidation, glutathione (GSH) and superoxide dismutase (SOD) activity, as antioxidant markers and ferric reducing ability of plasma (FRAP), as a marker of total antioxidant capacity. There was significant increase in the levels of MDA in CSX patients comparing to controls (3.8 +/- 0.12 vs 3.3 +/- 0.14 mM, respectively; p = 0.006). But thelevels of FRAP in CSX patients were significantly lower than those controls (504 +/- 19 vs 568 +/- 26 mu M, respectively; p = 0.046). Also, GSH levels and SOD activity in patients were significantly lower than those of the controls (GSH: 133.6 +/- 5.4 vs 152.5 +/- 7.8 mmol/g Hb, p = 0.048; SOD: 386 +/- 34 vs 578 +/- 38 U/g Hb, p = 0.0001). It may be concluded that there is systemic oxidative stress in CSX patients. Considerable changes of antioxidant concentrations, indicating a compensatory mechanism to cope with increased oxidative stress in CSX patients and the body's antioxidant defence mechanisms try to minimize oxidative stress damage.
C1 [Rasmi, Yousef] Urmia Univ Med Sci, Ctr Cellular & Mol Res, Orumiyeh, Iran.
   [Seydi-Shirvani, Sam; Khosravifar, Fariba] Payame Noor Univ, Dept Biochem, Tehran, Iran.
   [Rasmi, Yousef] Urmia Univ Med Sci, Dept Biochem, Fac Med, Orumiyeh, Iran.
   [Seyyed-Mohammadzad, Mir-Hossein] Urmia Univ Med Sci, Fac Med, Dept Cardiol, Orumiyeh, Iran.
C3 Urmia University of Medical Sciences; Payame Noor University; Urmia
   University of Medical Sciences; Urmia University of Medical Sciences
RP Rasmi, Y (corresponding author), Urmia Univ Med Sci, Ctr Cellular & Mol Res, Orumiyeh, Iran.
EM rasmiy@unisu.ac.ir
RI Seyed-Mohammadzad, MirHossein/V-7699-2017; Rasmi, Prof.
   Yousef/H-1783-2017
OI Rasmi, Prof. Yousef/0000-0003-1506-1909
FU Urmia University of Medical Sciences, Urmia, Iran
FX This work derived from a Master of Science thesis in biochemistry and
   supported by research grant from the Urmia University of Medical
   Sciences, Urmia, Iran.
CR Ammann P, 2000, CHEST, V117, P333, DOI 10.1378/chest.117.2.333
   Aparna P., 2010, INT J BIOL MED RES, V1, P125
   Aviram M, 2000, FREE RADICAL RES, V33, pS85
   Benzie IFF, 1996, ANAL BIOCHEM, V239, P70, DOI 10.1006/abio.1996.0292
   Buffon A, 2000, AM J PHYSIOL-HEART C, V279, pH2627, DOI 10.1152/ajpheart.2000.279.6.H2627
   BUTLER RN, 1994, J GASTROEN HEPATOL, V9, P60, DOI 10.1111/j.1440-1746.1994.tb01217.x
   Cavalca V, 2001, CLIN CHEM, V47, P887
   Celik T, 2006, J HYPERTENS, V24, P591, DOI 10.1097/01.hjh.0000209993.26057.de
   Chauhan A, 1997, EUR HEART J, V18, P60
   Crea F, 2004, HEART, V90, P457, DOI 10.1136/hrt.2003.020594
   Dikici I, 2005, CLIN BIOCHEM, V38, P1141, DOI 10.1016/j.clinbiochem.2005.10.006
   Elhadd TA, 1998, DIABETES CARE, V21, P1990, DOI 10.2337/diacare.21.11.1990
   Erdamar H, 2009, CORONARY ARTERY DIS, V20, P238, DOI 10.1097/MCA.0b013e32830936bb
   Gur M, 2007, CORONARY ARTERY DIS, V18, P89, DOI 10.1097/MCA.0b013e32801104e8
   HALLIWELL B, 1994, NUTR REV, V52, P253
   Hurst T, 2006, AM J MED, V119, P560, DOI 10.1016/j.amjmed.2005.07.009
   KAMAL AAM, 1989, ENVIRON RES, V49, P173, DOI 10.1016/S0013-9351(89)80062-3
   Kaski JC, 2006, HEART, V92, P5, DOI 10.1136/hrt.2005.070318
   Kaski Juan Carlos, 2004, Am J Cardiovasc Drugs, V4, P179, DOI 10.2165/00129784-200404030-00005
   KEMP HG, 1973, AM J CARDIOL, V32, P375, DOI 10.1016/S0002-9149(73)80150-X
   KRAMER JH, 1984, CIRC RES, V55, P120, DOI 10.1161/01.RES.55.1.120
   MARX JL, 1987, SCIENCE, V235, P529, DOI 10.1126/science.3810154
   On YK, 2005, CIRC J, V69, P1212, DOI 10.1253/circj.69.1212
   RAJGURU SU, 1994, LIFE SCI, V54, P149, DOI 10.1016/0024-3205(94)00584-2
   Rasmi Y, 2009, CARDIOL J, V16, P585
   Risal S, 2006, Kathmandu Univ Med J (KUMJ), V4, P271
   Satake O, 2004, CIRC J, V68, P220, DOI 10.1253/circj.68.220
   Srinivas K, 2000, Indian Heart J, V52, P285
   VANE JR, 1990, NEW ENGL J MED, V323, P27
NR 29
TC 2
Z9 3
U1 0
U2 4
PU SCIENCE SOCIETY THAILAND
PI BANGKOK
PA PUBLIC INFORMATION DEPT, 73/1 RAMA VI RD, RAJDHEVEE, BANGKOK, 00000,
   THAILAND
SN 1513-1874
J9 SCIENCEASIA
JI Scienceasia
PD JUN
PY 2012
VL 38
IS 2
BP 136
EP 140
DI 10.2306/scienceasia1513-1874.2012.38.136
PG 5
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 979MH
UT WOS:000306823600002
DA 2025-06-11
ER

PT J
AU Correia, J
   Ravasco, P
AF Correia, Jeronima
   Ravasco, Paula
TI Weight changes in Portuguese patients with depression: which factors are
   involved?
SO NUTRITION JOURNAL
LA English
DT Article
DE Depression; Nutrition; Weight changes; Food intake; Physical activity;
   Psychiatric drugs
ID PSYCHIATRIC-DISORDERS; METABOLIC SYNDROME; ABDOMINAL OBESITY;
   PHYSICAL-ACTIVITY; MAJOR DEPRESSION; OVERWEIGHT; ASSOCIATION; SYMPTOMS;
   HEALTH
AB Background & Aims: Depression may lead to obesity, just as obesity can contribute to the disease; yet, changes in the dietary pattern and food habits in depressive syndromes have been scantily investigated. We aimed to identify possible associations between nutritional factors and depressive disorder.
   Methods: This cross sectional study included 127 consecutive ambulatory adult patients with depression (DSM-IV), under psychiatric treatment. All study parameters were classified according to sex & age: BMI, waist circumference, % fat mass, food intake & physical activity.
   Results: Patients' mean age was 48 +/- 13 (18-81) yrs, 94% were women. Overweight/obesity was found in 72% of the cohort, 72% had excessive fat mass & 69% had a waist circumference above the maximum cut-off value. Longer disease was associated with higher BMI +% fat mass, p < 0.003. Weight gain during illness was registered in 87%; just 12% lost weight, though undernutrition did not occur. Weight gain and greater fat mass were related with higher BMI, p = 0.002. The pattern of food intake was poor, monotonous and inadequate in 59% of patients; there was also a regular consumption of hypercaloric foods by 78% pts. Overall, the usual diet was associated with weight gain, p = 0.002. Antidepressants (75%) and benzodiazepines (72%) were prevalent; these drugs were associated with weight gain, p = 0.01; 80% pts did not practice any physical activity.
   Conclusions: There was a positive association with overweight/obesity: a striking & clinically worrying prevalence of high fat mass, abdominal fat, weight gain, poor nutritional intake and sedentarism. This unhealthy pattern points towards the need of a multidisciplinary approach to promote healthy lifestyles that may help depressive disorder management.
C1 [Ravasco, Paula] Univ Lisbon, Fac Med, Lab Nutr, P-1649028 Lisbon, Portugal.
   [Ravasco, Paula] Hosp Univ Santa Maria, P-1649028 Lisbon, Portugal.
   [Correia, Jeronima] Hosp Nossa Senhora Rosario EPE, Psychiat Dept, Barreiro, Portugal.
C3 Universidade de Lisboa; Universidade de Lisboa; Hospital Santa Maria
RP Ravasco, P (corresponding author), Univ Lisbon, Fac Med, Lab Nutr, Ave Prof Egas Moniz, P-1649028 Lisbon, Portugal.
EM p.ravasco@medicina.ulisboa.pt
OI Ravasco, Paula/0000-0002-6056-8269
FU Fundacao para a Cincia e Tecnologia [RUN 437]
FX This study was partially supported by a Grant from the "Fundacao para a
   Cincia e Tecnologia" (RUN 437).
CR American Dietetic Association, DIET FOOD HLTH WEIGH
   American Psyquiatric Association, 2004, DIAGN STAT MAN MENT, P345
   Arroll B, 1991, Epidemiology, V2, P296, DOI 10.1097/00001648-199107000-00011
   British Nutrition Foundation, NUTR HLTH LIV
   Heymsfield S., 2006, Modern nutrition in health and disease, VTenth
   Hrabosky JI, 2008, CLIN PSYCHOL-SCI PR, V15, P28, DOI 10.1111/j.1468-2850.2008.00108.x
   Instituto Nacional de Estatistica, 2007, 4 INQ NAC SAUD 2005
   Khandelwal S., 2001, Conquering depression
   Kloiber S, 2007, BIOL PSYCHIAT, V62, P321, DOI 10.1016/j.biopsych.2006.10.001
   Laquatra I, 2008, KRAUSE FOOD NUTR DIE, P469
   Lean MEJ, 2000, P NUTR SOC, V59, P331, DOI 10.1017/S0029665100000379
   Lopes C., 2000, Alimentacao e Enfarte agudo do miocardio: Estudo de caso-controlo de base comunitaria, P78
   Markowitz S, 2008, CLIN PSYCHOL-SCI PR, V15, P1, DOI 10.1111/j.1468-2850.2008.00106.x
   Miettola J, 2008, SCAND J PRIM HEALTH, V26, P203, DOI 10.1080/02813430802117624
   Mikolajczyk RT, 2009, NUTR J, V8, DOI 10.1186/1475-2891-8-31
   National Institutes of Health - National heart lung and blood Institute, 2001, ATP 3 GUID AT A GLAN
   Newcomer JW, 2007, AM J MANAG CARE, V13, pS170
   Ocke MC, 1997, AM J CLIN NUTR, V65, P1240
   Pagoto S, 2007, OBESITY, V15, P2557, DOI 10.1038/oby.2007.307
   Papakostas GI, 2008, J CLIN PSYCHIAT, V69, P1287, DOI 10.4088/JCP.v69n0812
   Parker G, 2007, BRIT J PSYCHIAT, V191, P351, DOI 10.1192/bjp.bp.106.033746
   Rapaport MH, 2002, AM J PSYCHIAT, V159, P637, DOI 10.1176/appi.ajp.159.4.637
   Reus V, 2008, HARRISONS PRINCIPLES, VII
   Schanze A, 2008, NEUROPSYCHOBIOLOGY, V57, P126, DOI 10.1159/000138915
   Schneider KL, 2008, BMC PSYCHIATRY, V8, DOI 10.1186/1471-244X-8-77
   Simon GE, 2006, ARCH GEN PSYCHIAT, V63, P824, DOI 10.1001/archpsyc.63.7.824
   Stecker T, 2006, PSYCHOSOMATICS, V47, P513, DOI 10.1176/appi.psy.47.6.513
   Tate DF, 2007, AM J CLIN NUTR, V85, P954, DOI 10.1093/ajcn/85.4.954
   Telles-Correia D, 2008, ACTA MEDICA PORT, V21, P247
   Vogelzangs N, 2008, ARCH GEN PSYCHIAT, V65, P1386, DOI 10.1001/archpsyc.65.12.1386
   Wang J, 2003, AM J CLIN NUTR, V77, P379, DOI 10.1093/ajcn/77.2.379
   Werrij MQ, 2006, PATIENT EDUC COUNS, V62, P126, DOI 10.1016/j.pec.2005.06.016
   Yu ZM, 2014, PREV MED, V61, P106, DOI 10.1016/j.ypmed.2013.12.022
   Zhao GX, 2011, BMC PSYCHIATRY, V11, DOI 10.1186/1471-244X-11-130
NR 34
TC 14
Z9 17
U1 0
U2 18
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2891
J9 NUTR J
JI Nutr. J.
PD DEC 16
PY 2014
VL 13
AR 117
DI 10.1186/1475-2891-13-117
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA AX8XT
UT WOS:000347189700001
PM 25516181
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Shan, HY
   Luo, RX
   Guo, XY
   Li, R
   Ye, ZH
   Peng, TL
   Liu, FT
   Yang, Z
AF Shan, Hongying
   Luo, Renxin
   Guo, Xuanying
   Li, Rong
   Ye, Zhenhong
   Peng, Tianliu
   Liu, Fenting
   Yang, Zi
TI Abnormal Endometrial Receptivity and Oxidative Stress in Polycystic
   Ovary Syndrome
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE polycystic ovary syndrome; endometrial receptivity; oxidative stress;
   molecular mechanism; hyperandrogenemia
ID INSULIN-RESISTANCE; MONONUCLEAR-CELLS; MAMMALIAN TARGET;
   GRANULOSA-CELLS; WOMEN; HYPERANDROGENISM; PCOS; INFLAMMATION;
   EXPRESSION; LEVEL
AB Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in women of childbearing age. Individual heterogeneity is evident, and the prevalence rate ranges between 6 and 15% globally. The prevalence rate of PCOS in Chinese women of childbearing age is 5.6%. The main manifestations are infertility, sparse menstruation, irregular vaginal bleeding, long-term endometrial hyperplasia, and endometrial cancer. PCOS is often associated with hyperandrogenemia, insulin resistance, hyperinsulinemia, obesity, metabolic syndrome, and intestinal flora disorder. Although there have been many studies in the past, the underlying pathophysiological mechanism of the disease is still unclear. Studies have shown that PCOS diseases and related complications are closely related to local oxidative stress imbalance in the endometrium, leading to poor endometrial receptivity and effects on pregnancy. Previous reviews have mainly focused on the abnormal mechanism of ovarian oxidative stress in women with PCOS, while reviews on endometrial receptivity and oxidative stress are relatively insufficient. This study reviews the abnormal cellular and molecular mechanisms of oxidative stress due to comorbidities in women with PCOS, leading to a downregulation of endometrial receptivity.
C1 [Shan, Hongying; Luo, Renxin; Guo, Xuanying; Li, Rong; Ye, Zhenhong; Peng, Tianliu; Liu, Fenting; Yang, Zi] Peking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing, Peoples R China.
   [Shan, Hongying] Shihezi Univ, Affiliated Hosp 1, Sch Med, Beijing, Peoples R China.
C3 Shihezi University
RP Li, R (corresponding author), Peking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing, Peoples R China.
EM roseli001@sina.com
RI Shan, Hongying/AAH-9946-2020; Li, Raymond/H-4442-2012; peng,
   Tianliu/MSW-1384-2025
OI peng, Tianliu/0000-0002-2680-2357
FU National Science Foundation for Distinguished Young Scholars [81925013];
   China Postdoctoral Science Foundation [2021M690259]
FX This study was supported by the "National Science Foundation for
   Distinguished Young Scholars, grant number 81925013" and the "China
   Postdoctoral Science Foundation grant number 2021M690259".
CR Agarwal A, 2012, REPROD BIOL ENDOCRIN, V10, DOI 10.1186/1477-7827-10-49
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Althobiti M, 2020, BREAST CANCER RES TR, V182, P581, DOI 10.1007/s10549-020-05719-x
   Amato G, 2003, OBSTET GYNECOL, V101, P1177, DOI 10.1016/S0029-7844(03)00233-3
   Ashary N, 2018, ENDOCRINOLOGY, V159, P1188, DOI 10.1210/en.2017-03082
   ASHKENAZI J, 1995, FERTIL STERIL, V64, P564, DOI 10.1016/S0015-0282(16)57793-0
   Azziz R, 2009, FERTIL STERIL, V91, P456, DOI 10.1016/j.fertnstert.2008.06.035
   Bansal S, 2021, INT J GYNECOL OBSTET, V152, P345, DOI 10.1002/ijgo.13375
   Belani M, 2018, J STEROID BIOCHEM, V178, P283, DOI 10.1016/j.jsbmb.2018.01.008
   Bloch-Damti A, 2005, ANTIOXID REDOX SIGN, V7, P1553, DOI 10.1089/ars.2005.7.1553
   Blumenfeld Z, 2019, CLIN MED INSIGHTS-RE, V13, DOI 10.1177/1179558119861936
   Cabrera-Cruz H, 2020, AM J PHYSIOL-ENDOC M, V318, pE237, DOI 10.1152/ajpendo.00162.2019
   Chakrabarty RP, 2021, CELL STEM CELL, V28, P394, DOI 10.1016/j.stem.2021.02.011
   Chang J, 2004, FERTIL STERIL, V81, P19, DOI 10.1016/j.fertnstert.2003.10.004
   Cheng YL, 2018, ENDOCR CONNECT, V7, P36, DOI 10.1530/EC-17-0315
   Chung HC, 2012, CELL, V149, P1578, DOI 10.1016/j.cell.2012.04.037
   Craciunas L, 2019, HUM REPROD UPDATE, V25, P202, DOI 10.1093/humupd/dmy044
   Dandona P, 2001, J CLIN ENDOCR METAB, V86, P3257, DOI 10.1210/jc.86.7.3257
   Ebejer K, 2013, GYNECOL ENDOCRINOL, V29, P536, DOI 10.3109/09513590.2012.760195
   El-Mansi AA, 2019, J FOOD BIOCHEM, V43, DOI 10.1111/jfbc.13001
   Enli Y, 2013, GYNECOL ENDOCRINOL, V29, P1036, DOI 10.3109/09513590.2013.829442
   Fauser BCJM, 2012, FERTIL STERIL, V97, P28, DOI 10.1016/j.fertnstert.2011.09.024
   Franks S, 2010, ANN ENDOCRINOL-PARIS, V71, P228, DOI 10.1016/j.ando.2010.02.007
   Glintborg D, 2016, ACTA OBSTET GYN SCAN, V95, P1235, DOI 10.1111/aogs.12964
   González F, 2006, J CLIN ENDOCR METAB, V91, P336, DOI 10.1210/jc.2005-1696
   González F, 2020, HUM REPROD, V35, P1168, DOI 10.1093/humrep/deaa056
   González F, 2012, J CLIN ENDOCR METAB, V97, P2836, DOI 10.1210/jc.2012-1259
   González F, 2012, AM J PHYSIOL-ENDOC M, V302, pE297, DOI 10.1152/ajpendo.00416.2011
   Gyuraszova M, 2017, MED HYPOTHESES, V103, P81, DOI 10.1016/j.mehy.2017.04.011
   Heard ME, 2016, ENDOCRINOLOGY, V157, P2870, DOI 10.1210/en.2016-1092
   Hilali N, 2013, CLIN ENDOCRINOL, V79, P105, DOI 10.1111/cen.12110
   Holvoet P, 2008, Verh K Acad Geneeskd Belg, V70, P193
   Hu M, 2019, LIFE SCI, V232, DOI 10.1016/j.lfs.2019.116681
   Inoguchi T, 2000, DIABETES, V49, P1939, DOI 10.2337/diabetes.49.11.1939
   Johnson RJ, 2013, DIABETES, V62, P3307, DOI 10.2337/db12-1814
   Krajmalnik-Brown R, 2012, NUTR CLIN PRACT, V27, P201, DOI 10.1177/0884533611436116
   LeRoith D, 2008, ENDOCRIN METAB CLIN, V37, pXIII, DOI 10.1016/j.ecl.2008.07.004
   Li R, 2013, HUM REPROD, V28, P2562, DOI 10.1093/humrep/det262
   Li RQ, 2017, MOL MED REP, V15, P2503, DOI 10.3892/mmr.2017.6322
   Liang YJ, 2020, CAN J PHYSIOL PHARM, V98, P803, DOI 10.1139/cjpp-2019-0413
   Lin XH, 2015, FERTIL STERIL, V103, P228, DOI 10.1016/j.fertnstert.2014.10.002
   Lindheim L, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0168390
   Liu R, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.00324
   Long XY, 2017, REPROD SCI, V24, P252, DOI 10.1177/1933719116653681
   Luo L, 2017, REPROD BIOMED ONLINE, V35, P576, DOI 10.1016/j.rbmo.2017.07.010
   Mahdi H, 2015, J SURG ONCOL, V112, P188, DOI 10.1002/jso.23993
   Mittler R, 2017, TRENDS PLANT SCI, V22, P11, DOI 10.1016/j.tplants.2016.08.002
   Mokhtar MH, 2020, IN VIVO, V34, P225, DOI 10.21873/invivo.11764
   Otani H, 2011, ANTIOXID REDOX SIGN, V15, P1911, DOI 10.1089/ars.2010.3739
   Palomba S, 2021, HUM REPROD UPDATE, V27, P584, DOI 10.1093/humupd/dmaa051
   Pei CZ, 2021, BIOMED PHARMACOTHER, V142, DOI 10.1016/j.biopha.2021.112031
   Peng Z, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0148531
   Blagojevic IMP, 2022, BRIT J NUTR, V128, P604, DOI 10.1017/S0007114521003585
   Qi XY, 2019, NAT MED, V25, P1225, DOI 10.1038/s41591-019-0509-0
   Rahman Tanzil Ur, 2018, Oncotarget, V9, P24627, DOI 10.18632/oncotarget.24821
   Rosas C, 2016, REPROD SCI, V23, P761, DOI 10.1177/1933719115618283
   Ruegsegger GN, 2018, J CLIN INVEST, V128, P3671, DOI 10.1172/JCI120843
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Samy N, 2009, DIS MARKERS, V26, P163, DOI [10.1155/2009/465203, 10.3233/DMA-2009-0627]
   Skorupskaite K, 2020, HUM REPROD, V35, P1421, DOI 10.1093/humrep/deaa104
   Soares AF, 2005, FREE RADICAL BIO MED, V38, P882, DOI 10.1016/j.freeradbiomed.2004.12.010
   Somers MJG, 2015, J CLIN PHARMACOL, V55, P368, DOI 10.1002/jcph.428
   Stepto NK, 2013, HUM REPROD, V28, P777, DOI 10.1093/humrep/des463
   Stevens BR, 2018, GUT, V67, P1555, DOI 10.1136/gutjnl-2017-314759
   Sturgeon C, 2016, TISSUE BARRIERS, V4, DOI 10.1080/21688370.2016.1251384
   Sun LY, 2012, J PROTEOME RES, V11, P2937, DOI 10.1021/pr3000317
   Sun Y, 2021, FERTIL STERIL, V116, P1641, DOI 10.1016/j.fertnstert.2021.07.1203
   Torres PJ, 2018, J CLIN ENDOCR METAB, V103, P1502, DOI 10.1210/jc.2017-02153
   Tremellen K, 2012, MED HYPOTHESES, V79, P104, DOI 10.1016/j.mehy.2012.04.016
   Vahidnezhad H, 2016, J INVEST DERMATOL, V136, P15, DOI 10.1038/JID.2015.331
   Varikasuvu SR, 2019, REPROD BIOMED ONLINE, V39, P685, DOI 10.1016/j.rbmo.2019.04.018
   Wang HS, 2019, ARCH GYNECOL OBSTET, V300, P1413, DOI 10.1007/s00404-019-05305-7
   Wataya-Kaneda M, 2015, J DERMATOL SCI, V79, P93, DOI 10.1016/j.jdermsci.2015.04.005
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Wollenhaupt K, 2013, REPROD BIOL, V13, P184, DOI 10.1016/j.repbio.2013.06.001
   Yland JJ, 2022, HUM REPROD, V37, P793, DOI 10.1093/humrep/deac005
   Zelzer S, 2011, CLIN CHIM ACTA, V412, P1345, DOI 10.1016/j.cca.2011.03.031
   Zeng B, 2019, RES MICROBIOL, V170, P43, DOI 10.1016/j.resmic.2018.09.002
   Zhang YH, 2019, J PHYSIOL-LONDON, V597, P3927, DOI 10.1113/JP277879
   Zhao Y, 2015, J CLIN ENDOCR METAB, V100, P201, DOI 10.1210/jc.2014-2419
NR 80
TC 27
Z9 29
U1 1
U2 28
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JUL 25
PY 2022
VL 13
AR 904942
DI 10.3389/fphar.2022.904942
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 3Q2IW
UT WOS:000838057800001
PM 35959444
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Khotskin, NV
   Plyusnina, AV
   Kulikova, EA
   Bazhenova, EY
   Fursenko, DV
   Sorokin, IE
   Kolotygin, I
   Mormede, P
   Terenina, EE
   Shevelev, OB
   Kulikov, AV
AF Khotskin, Nikita V.
   Plyusnina, Alexandra V.
   Kulikova, Elizabeth A.
   Bazhenova, Ekaterina Y.
   Fursenko, Daryia V.
   Sorokin, Ivan E.
   Kolotygin, Ilia
   Mormede, Pierre
   Terenina, Elena E.
   Shevelev, Oleg B.
   Kulikov, Alexander V.
TI On association of the lethal yellow (A<SUP>Y</SUP>) mutation in
   the agouti gene with the alterations in mouse brain and behavior
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Lethal yellow; Behavior; MRI; Brain; Mice
ID TYROSINE-PHOSPHATASE STEP; BODY-MASS INDEX; MELANOCORTIN-4 RECEPTOR;
   METABOLIC SYNDROME; MICE; PROTEIN; DEPRESSION; OBESITY; INFLAMMATION;
   EXPRESSION
AB Lethal yellow (A(Y)) mutation causes obesity and type-2 diabetes in mice. Here we studied the effect of the A(Y) mutation on the brain and behavior. The experiments were carried out on adult (11-12 weeks old) males of A(Y)/a mice and their wild-type littermates (a/a). Mice of A(Y)/a and a/a genotypes did not differ in their home cage activity, sleep, food and water consumption, learning ability in the Morris water maze, anxiety in the open field and elevated plus-maze, as well as in the level of monoamines, metabolites and some genes expression in the brain. At the same time, the fat mass, depressive-like immobility in the forced swim and tail suspension tests were significantly increased in A(Y)/a mice compared with a/a ones. Magnetic resonance imaging revealed a significant reduction of cortex volume in A(Y)/a mice. The level of mRNA of Ptpn5 gene encoding striatal enriched tyrosine phosphatase in the frontal cortex of A(Y)/a mice was significantly elevated compared with their wild-type littermates. This is the first report on the alterations in the brain and behavior in the A(Y)/a mouse line. It is tempting to speculate that this mouse line can serve as a new and useful preclinical model to study neurobehavioral complications associated with obesity and type-2 diabetes.
C1 [Khotskin, Nikita V.; Plyusnina, Alexandra V.; Kulikova, Elizabeth A.; Bazhenova, Ekaterina Y.; Fursenko, Daryia V.; Sorokin, Ivan E.; Shevelev, Oleg B.; Kulikov, Alexander V.] Inst Cytol & Genet SB RAS, Fed Res Ctr, Ave Lavrentyev 10, Novosibirsk 630090, Russia.
   [Kolotygin, Ilia] Novosibirsk State Univ, Novosibirsk 630090, Russia.
   [Mormede, Pierre; Terenina, Elena E.] Univ Toulouse, GenPhySE, INRA, INP,ENSAT,ENVT, F-31326 Castanet Tolosan, France.
C3 Russian Academy of Sciences; Siberian Branch of the Russian Academy of
   Sciences; Institute of Cytology & Genetics ICG SB RAS; Novosibirsk State
   University; Universite de Toulouse; Ecole Nationale Veterinaire de
   Toulouse; INRAE; Centre National de la Recherche Scientifique (CNRS);
   CNRS - Institute of Physics (INP); Universite Federale Toulouse
   Midi-Pyrenees (ComUE); Institut National Polytechnique de Toulouse
RP Kulikov, AV (corresponding author), Inst Cytol & Genet SB RAS, Fed Res Ctr, Ave Lavrentyev 10, Novosibirsk 630090, Russia.
EM akulikov@ngs.ru
RI Plyusnina, Aleksandra/ABA-9403-2020; Fursenko, Dariya/ABF-4273-2021;
   Kulikova, Elizabeth/AAD-4843-2020; Kulikov, Alexander/AAD-4870-2020;
   Khotskin, Nikita/AAE-9026-2020; Shevelev, Oleg/U-9436-2017; Mormede,
   Pierre/K-5537-2015
OI Fursenko, Dariya/0000-0003-0386-7315; Khotskin,
   Nikita/0000-0003-2187-2601; Terenina, Elena/0009-0005-1398-4525;
   Kulikova, Elizabeth/0000-0001-9102-1525; Mormede,
   Pierre/0000-0003-0345-1432
FU Russian Science Foundation [17-15-01032]; Russian Science Foundation
   [17-15-01032] Funding Source: Russian Science Foundation
FX The study has been supported by the Russian Science Foundation (grant No
   17-15-01032).
CR Bains RS, 2018, J NEUROSCI METH, V300, P37, DOI 10.1016/j.jneumeth.2017.04.014
   Bazhan NM, 2013, PHYSIOL BEHAV, V120, P19, DOI 10.1016/j.physbeh.2013.06.023
   Bazhenova EY, 2017, NEUROSCI LETT, V653, P264, DOI 10.1016/j.neulet.2017.05.070
   Belzung C, 2011, BIOL MOOD ANXIETY DI, V1, DOI 10.1186/2045-5380-1-9
   Boston BA, 1997, SCIENCE, V278, P1641, DOI 10.1126/science.278.5343.1641
   BOULANGER LM, 1995, J NEUROSCI, V15, P1532
   Castanon N, 2015, FRONT NEUROSCI-SWITZ, V9, DOI 10.3389/fnins.2015.00229
   Chaki S, 2005, PHARMACOL BIOCHEM BE, V82, P621, DOI 10.1016/j.pbb.2005.11.001
   Chaki S, 2005, PEPTIDES, V26, P1952, DOI 10.1016/j.peptides.2004.11.029
   Chaki S, 2007, CURR TOP MED CHEM, V7, P1145
   Charan J, 2013, J PHARMACOL PHARMACO, V4, P303, DOI 10.4103/0976-500X.119726
   Clark RE, 2007, J NEUROSCI, V27, P6647, DOI 10.1523/JNEUROSCI.0913-07.2007
   Cournot M, 2006, NEUROLOGY, V67, P1208, DOI 10.1212/01.wnl.0000238082.13860.50
   Cryan JF, 2004, MOL PSYCHIATR, V9, P326, DOI 10.1038/sj.mp.4001457
   Dahl AK, 2013, EPIDEMIOL REV, V35, P22, DOI 10.1093/epirev/mxs002
   Dalm S, 2000, BEHAV RES METH INS C, V32, P134, DOI 10.3758/BF03200795
   Dalm S, 2009, BEHAV BRAIN RES, V198, P98, DOI 10.1016/j.bbr.2008.10.016
   Dantzer R, 2017, CURR TOP BEHAV NEURO, V31, P117, DOI 10.1007/7854_2016_6
   Di Giovanni G, 2016, FRONT NEUROSCI-SWITZ, V10, DOI 10.3389/fnins.2016.00541
   Dinel AL, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024325
   Ernst A, 2013, TRANSL PSYCHIAT, V3, DOI 10.1038/tp.2013.42
   Farooqui AA, 2012, CELL MOL LIFE SCI, V69, P741, DOI 10.1007/s00018-011-0840-1
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Fisher SP, 2012, J BIOL RHYTHM, V27, P48, DOI 10.1177/0748730411431550
   Fitzpatrick CJ, 2011, FRONT NEUROANAT, V5, DOI 10.3389/fnana.2011.00047
   GALLAGHER M, 1993, BEHAV NEUROSCI, V107, P618, DOI 10.1037/0735-7044.107.4.618
   GARRIS DR, 1995, DEV BRAIN RES, V89, P314
   Goebel-Goody SM, 2012, PHARMACOL REV, V64, P65, DOI 10.1124/pr.110.003053
   Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
   Guan ZF, 2017, CNS NEUROSCI THER, V23, P462, DOI 10.1111/cns.12691
   Guo M, 2014, TRANSL PSYCHIAT, V4, DOI 10.1038/tp.2014.126
   Hof P., 2000, Comparative cytoarchitectonic atlas of the C57BL/6 and 129/SV mouse brains, V1
   Karasawa T, 2014, NEUROSCI RES, V89, P1, DOI 10.1016/j.neures.2014.08.018
   Kennedy JT, 2016, FRONT NEUROSCI-SWITZ, V10, DOI 10.3389/fnins.2016.00413
   [Хоцкин Н.В. Khotskin N.V.], 2017, [Вавиловский журнал генетики и селекции, VAVILOVSKII ZHURNAL GENETIKI I SELEKTSII = VAVILOV JOURNAL OF GENETICS AND BREEDING, Vavilovskii zhurnal genetiki i selektsii], V21, P804, DOI 10.18699/VJ17.297
   [Хоцкин Н.В. Khotskin N.V.], 2015, [Вавиловский журнал генетики и селекции, Russian Journal of Genetics: Applied Research, Vavilovskii zhurnal genetiki i selektsii], V19, P388, DOI 10.18699/VJ15.049
   Kulikov AV, 2008, J NEUROSCI METH, V170, P345, DOI 10.1016/j.jneumeth.2008.01.024
   Kulikov AV, 2014, LETT DRUG DES DISCOV, V11, P169
   Kulikov AV, 2010, J NEUROSCI METH, V191, P26, DOI 10.1016/j.jneumeth.2010.06.002
   Kulikov VA, 2014, J NEUROSCI METH, V235, P219, DOI 10.1016/j.jneumeth.2014.07.012
   Kulikova EA, 2015, ZH VYSSH NERV DEYAT+, V65, P105, DOI 10.7868/S0044467715010050
   Kulikova E, 2017, CURR PROTEIN PEPT SC, V18, P1152, DOI 10.2174/1389203718666170710121532
   Lad HV, 2010, PHYSIOL BEHAV, V99, P301, DOI 10.1016/j.physbeh.2009.11.007
   Leo L, 2016, BIOPROTOCOL, V4, DOI [10.21769/BioProtoc.1211, DOI 10.21769/BIOPROTOC.1211, 10.21769/bioprotoc.1211, DOI 10.21769/BI0PR0T0C]
   Li HY, 2018, REJUV RES, V21, P200, DOI 10.1089/rej.2017.1972
   Lojko D, 2015, J AFFECT DISORDERS, V185, P76, DOI 10.1016/j.jad.2015.06.020
   Lorber B, 2004, MOL CELL NEUROSCI, V27, P404, DOI 10.1016/j.mcn.2004.06.012
   LU DS, 1994, NATURE, V371, P799, DOI 10.1038/371799a0
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Marissal-Arvy N, 2014, BRIT J NUTR, V111, P1190, DOI 10.1017/S0007114513003577
   Marosi K, 2014, TRENDS ENDOCRIN MET, V25, P89, DOI 10.1016/j.tem.2013.10.006
   Martin AA, 2014, PHYSIOL BEHAV, V136, P185, DOI 10.1016/j.physbeh.2014.02.062
   McCrimmon RJ, 2012, LANCET, V379, P2291, DOI 10.1016/S0140-6736(12)60360-2
   Pack AI, 2007, PHYSIOL GENOMICS, V28, P232, DOI 10.1152/physiolgenomics.00139.2006
   Paylor R, 2006, PHYSIOL BEHAV, V87, P95, DOI 10.1016/j.physbeh.2005.09.002
   PERRY WL, 1994, BIOESSAYS, V16, P705, DOI 10.1002/bies.950161002
   Prickett C, 2015, OBES RES CLIN PRACT, V9, P93, DOI 10.1016/j.orcp.2014.05.001
   Rizzo SJS, 2014, GENES BRAIN BEHAV, V13, P643, DOI 10.1111/gbb.12169
   Roberts RO, 2010, ALZ DIS ASSOC DIS, V24, P11, DOI 10.1097/WAD.0b013e3181a4485c
   Sabia S, 2009, AM J CLIN NUTR, V89, P601, DOI 10.3945/ajcn.2008.26482
   Savitz J, 2017, CURR TOP BEHAV NEURO, V31, P249, DOI 10.1007/7854_2016_12
   Schwartz MW, 2000, NATURE, V404, P661, DOI 10.1038/35007534
   Sharma AN, 2010, PHYSIOL BEHAV, V101, P381, DOI 10.1016/j.physbeh.2010.07.002
   Shiflett MW, 2015, TRANSL PSYCHIAT, V5, DOI 10.1038/tp.2015.17
   Simon GE, 2006, ARCH GEN PSYCHIAT, V63, P824, DOI 10.1001/archpsyc.63.7.824
   Stranahan AM, 2009, HIPPOCAMPUS, V19, P951, DOI 10.1002/hipo.20577
   Stunkard AJ, 2003, BIOL PSYCHIAT, V54, P330, DOI 10.1016/S0006-3223(03)00608-5
   Tsukamoto A, 2015, EXP ANIM TOKYO, V64, P57, DOI 10.1538/expanim.14-0050
   Venkitaramani DV, 2011, EUR J NEUROSCI, V33, P2288, DOI 10.1111/j.1460-9568.2011.07687.x
   Voikar V, 2004, GENES BRAIN BEHAV, V3, P27, DOI 10.1046/j.1601-183X.2003.0044.x
   Voronova IP, 2016, PHARMACOL RES, V103, P123, DOI 10.1016/j.phrs.2015.11.018
   Wang H, 2018, NEUROPHARMACOLOGY, V131, P143, DOI 10.1016/j.neuropharm.2017.12.026
   Willette AA, 2015, AGEING RES REV, V20, P86, DOI 10.1016/j.arr.2014.03.007
   Willner P, 2002, BEHAV PHARMACOL, V13, P169, DOI 10.1097/00008877-200205000-00001
   Xu J, 2014, PLOS BIOL, V12, DOI 10.1371/journal.pbio.1001923
   Zhang YF, 2010, P NATL ACAD SCI USA, V107, P19014, DOI 10.1073/pnas.1013543107
NR 76
TC 27
Z9 27
U1 0
U2 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD FEB 1
PY 2019
VL 359
BP 446
EP 456
DI 10.1016/j.bbr.2018.11.013
PG 11
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA HI1RL
UT WOS:000456222600053
PM 30447239
DA 2025-06-11
ER

PT J
AU Ditzen, C
   Tang, N
   Jastorff, AM
   Teplytska, L
   Yassouridis, A
   Maccarrone, G
   Uhr, M
   Bronisch, T
   Miller, CA
   Holsboer, F
   Turck, CW
AF Ditzen, Claudia
   Tang, Ning
   Jastorff, Archana M.
   Teplytska, Larysa
   Yassouridis, Alexander
   Maccarrone, Giuseppina
   Uhr, Manfred
   Bronisch, Thomas
   Miller, Christine A.
   Holsboer, Florian
   Turck, Christoph W.
TI Cerebrospinal Fluid Biomarkers for Major Depression Confirm Relevance of
   Associated Pathophysiology
SO NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE major depression; cerebrospinal fluid biomarkers; phosphoproteins; PEDF;
   cystatin C; PGDS
ID ELEMENT-BINDING PROTEIN; CELL-ADHESION MOLECULE; METABOLIC SYNDROME;
   ALZHEIMERS-DISEASE; SUICIDE ATTEMPTERS; PROSTAGLANDIN D-2; CYSTATIN-C;
   CSF; DISORDER; SLEEP
AB Individual characteristics of pathophysiology and course of depressive episodes are at present not considered in diagnostics. There are no biological markers available that can assist in categorizing subtypes of depression and detecting molecular variances related to disease-causing mechanisms between depressed patients. Identification of such differences is important to create patient subgroups, which will benefit from medications that specifically target the pathophysiology underlying their clinical condition. To detect characteristic biological markers for major depression, we analyzed the cerebrospinal fluid (CSF) proteome of depressed vs control persons, using two-dimensional polyacrylamide gel electrophoresis and time-of-flight (TOF) mass spectrometry peptide profiling. Proteins of interest were identified by matrix-assisted laser desorption ionization TOF mass spectrometry (MALDI-TOF-MS). Validation of protein markers was performed by immunoblotting. We found 11 proteins and 144 peptide features that differed significantly between CSF from depressed patients and controls. In addition, we detected differences in the phosphorylation pattern of several CSF proteins. A subset of the differentially expressed proteins implicated in brain metabolism or central nervous system disease was validated by immunoblotting. The identified proteins are involved in neuroprotection and neuronal development, sleep regulation, and amyloid plaque deposition in the aging brain. This is one of the first hypothesis-free studies that identify characteristic protein expression differences in CSF of depressed patients. Proteomic approaches represent a powerful tool for the identification of disease markers for subgroups of patients with major depression. Neuropsychopharmacology (2012) 37, 1013-1025; doi: 10.1038/npp.2011.285; published online 14 December 2011
C1 [Ditzen, Claudia; Jastorff, Archana M.; Teplytska, Larysa; Yassouridis, Alexander; Maccarrone, Giuseppina; Uhr, Manfred; Bronisch, Thomas; Holsboer, Florian; Turck, Christoph W.] Max Planck Inst Psychiat, D-80804 Munich, Germany.
   [Tang, Ning; Miller, Christine A.] Agilent Technol, Santa Clara, CA USA.
C3 Max Planck Society; Agilent Technologies
RP Ditzen, C (corresponding author), Max Planck Inst Psychiat, Kraepelinstr 2, D-80804 Munich, Germany.
EM ditzen@mpipsykl.mpg.de
RI Turck, Christoph/ADE-0191-2022; Miller, Christine/A-8950-2008
FU German Federal Ministry of Science and Education (NGFN MooDS)
FX This study was supported by the German Federal Ministry of Science and
   Education (NGFN MooDS).
CR aan het Rot M, 2009, CAN MED ASSOC J, V180, P305, DOI 10.1503/cmaj.080697
   Brümmer D, 1998, J MOL MED, V76, P355, DOI 10.1007/s001090050227
   Brunner J, 2005, EUR ARCH PSY CLIN N, V255, P438, DOI 10.1007/s00406-005-0575-9
   Capuron L, 2008, BIOL PSYCHIAT, V64, P896, DOI 10.1016/j.biopsych.2008.05.019
   Carpenter LL, 2004, J AFFECT DISORDERS, V79, P285, DOI 10.1016/S0165-0327(02)00460-3
   Eguchi N, 1999, P NATL ACAD SCI USA, V96, P726, DOI 10.1073/pnas.96.2.726
   Geracioti TD, 1997, BIOL PSYCHIAT, V42, P165, DOI 10.1016/S0006-3223(96)00312-5
   Gnanapavan S, 2010, J NEUROIMMUNOL, V225, P118, DOI 10.1016/j.jneuroim.2010.04.020
   Henneman WJP, 2009, NEUROLOGY, V73, P935, DOI 10.1212/WNL.0b013e3181b879ac
   Hennings JM, 2008, J PSYCHIATR RES, V43, P215, DOI 10.1016/j.jpsychires.2008.05.002
   Ising M, 2009, ARCH GEN PSYCHIAT, V66, P966, DOI 10.1001/archgenpsychiatry.2009.95
   Jacob Archana M., 2008, V446, P21, DOI 10.1007/978-1-60327-084-7_2
   Jakovjevic M, 2007, PSYCHIAT DANUB, V19, P76
   Jastorff AM, 2009, PROTEOM CLIN APPL, V3, P1273, DOI 10.1002/prca.200800155
   Jokinen J, 2008, J AFFECT DISORDERS, V111, P119, DOI 10.1016/j.jad.2008.02.001
   Kaeser SA, 2007, NAT GENET, V39, P1437, DOI 10.1038/ng.2007.23
   KANTHA SS, 1994, PROSTAG LEUKOTR ESS, V51, P87, DOI 10.1016/0952-3278(94)90083-3
   Krishnan V, 2010, AM J PSYCHIAT, V167, P1305, DOI 10.1176/appi.ajp.2009.10030434
   Lee S, 2010, MOL BRAIN, V3, DOI 10.1186/1756-6606-3-8
   Levy E, 2006, BRAIN PATHOL, V16, P60, DOI 10.1111/j.1750-3639.2006.tb00562.x
   Lottspeich F, 2010, SCAND J CLIN LAB INV, V70, P19, DOI 10.3109/00365513.2010.493359
   Luo LQ, 2010, NAT REV NEUROSCI, V11, P718, DOI 10.1038/nrn2912
   Maccarrone G, 2004, ELECTROPHORESIS, V25, P2402, DOI 10.1002/elps.200305909
   MATSUMURA H, 1994, P NATL ACAD SCI USA, V91, P11998, DOI 10.1073/pnas.91.25.11998
   Petzold A, 2009, J NEUROL SCI, V279, P76, DOI 10.1016/j.jns.2008.12.037
   Pijnenburg YAL, 2007, DEMENT GERIATR COGN, V23, P225, DOI 10.1159/000099473
   Poltorak M, 1996, J NEUROCHEM, V66, P1532
   Popoli M, 2000, J NEUROCHEM, V74, P21, DOI 10.1046/j.1471-4159.2000.0740021.x
   Richter N, 2010, EUR ARCH PSY CLIN N, V260, P41, DOI 10.1007/s00406-009-0013-5
   Rush AJ, 2006, AM J PSYCHIAT, V163, P1905, DOI 10.1176/appi.ajp.163.11.1905
   Shaw LM, 2009, ANN NEUROL, V65, P403, DOI 10.1002/ana.21610
   Sullivan GM, 2006, INT J NEUROPSYCHOPH, V9, P547, DOI 10.1017/S1461145705006231
   Taurines R, 2011, J PSYCHOPHARMACOL, V25, P151, DOI 10.1177/0269881109106931
   Tombran-Tink J, 2003, NAT REV NEUROSCI, V4, P628, DOI 10.1038/nrn1176
   Turck Christoph W, 2005, J Med Invest, V52 Suppl, P231, DOI 10.2152/jmi.52.231
   Urade Y, 1999, BBA-MOL CELL BIOL L, V1436, P606, DOI 10.1016/S0005-2760(98)00163-5
   Vawter MP, 2000, J PSYCHIATR RES, V34, P25, DOI 10.1016/S0022-3956(99)00026-6
   Vawter MP, 2000, EUR J PHARMACOL, V405, P385, DOI 10.1016/S0014-2999(00)00568-9
   Vogelzangs N, 2007, PSYCHONEUROENDOCRINO, V32, P151, DOI 10.1016/j.psyneuen.2006.11.009
   Yabe T, 2005, NEUROSCIENCE, V133, P691, DOI 10.1016/j.neuroscience.2005.03.007
   Yamada S, 2003, J NEURAL TRANSM, V110, P671, DOI 10.1007/s00702-002-0810-8
   Yamashima T, 1997, J NEUROSCI, V17, P2376
   Yuan XL, 2002, ELECTROPHORESIS, V23, P1185, DOI 10.1002/1522-2683(200204)23:7/8<1185::AID-ELPS1185>3.0.CO;2-G
   Zougman A, 2008, J PROTEOME RES, V7, P386, DOI 10.1021/pr070501k
NR 44
TC 78
Z9 81
U1 0
U2 13
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0893-133X
EI 1740-634X
J9 NEUROPSYCHOPHARMACOL
JI Neuropsychopharmacology
PD MAR
PY 2012
VL 37
IS 4
BP 1013
EP 1025
DI 10.1038/npp.2011.285
PG 13
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 896PB
UT WOS:000300580100017
PM 22169944
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Tapsell, LC
   Lonergan, M
   Martin, A
   Batterham, MJ
   Neale, EP
AF Tapsell, Linda C.
   Lonergan, Maureen
   Martin, Allison
   Batterham, Marijka J.
   Neale, Elizabeth P.
CA Hlth Track Study Team
TI Interdisciplinary lifestyle intervention for weight management in a
   community population (Health Track study): Study design and baseline
   sample characteristics
SO CONTEMPORARY CLINICAL TRIALS
LA English
DT Article
DE Interdisciplinary; Study protocol; Clinical trial; Health services;
   Overweight
ID PSYCHOMETRIC PROPERTIES; TRIAL; QUESTIONNAIRE; DIET; VALIDATION;
   ACCEPTANCE; PREVENTION; VALIDITY; WALNUTS; DISEASE
AB Background: Integrating professional expertise in diet, exercise and behavioural support may provide more effective preventive health services but this needs testing. We describe the design and baseline results of a trial in the Illawarra region of New South Wales, Australia.
   Methods: The HealthTrack study is a 12 month randomised controlled trial testing effects of a novel interdisciplinary lifestyle intervention versus usual care. The study recruited overweight and obese adults 25-54 years resident in the Illawarra. Primary outcomes were weight, and secondary outcomes were disease risk factors (lipids, glucose, blood pressure), and behaviour (diet, activity, and psychological factors). Protocols, recruitment and baseline characteristics are reported.
   Results: Between May 2014 and April 2015, 377 participants were recruited and randomised. The median age (IQR) of the mostly female sample (74%) was 45 (37-51) years. The sample comprised obese (BMI 32 (29-35) kg/m(2)) well educated (79% post school qualifications) non-smokers (96%). A high proportion reported suffering from anxiety (26.8%) and depression (33.7%). Metabolic syndrome was identified in 34.9% of the sample.
   Conclusions: The HealthTrack study sample was recruited to test the effectiveness of an interdisciplinary approach to preventive healthcare in self-identified overweight adults in the Illawarra region. The profile of participants gives some indication of those likely to use services similar to the trial design. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Tapsell, Linda C.; Martin, Allison; Neale, Elizabeth P.] Univ Wollongong, Sch Med, Fac Sci Med & Hlth, Wollongong, NSW 2522, Australia.
   [Tapsell, Linda C.; Lonergan, Maureen; Martin, Allison; Neale, Elizabeth P.] Univ Wollongong, Illawarra Hlth & Med Res Inst, Wollongong, NSW 2522, Australia.
   [Lonergan, Maureen] Wollongong Hosp, Illawarrd Shoalhaven Local Hlth Dist, Renal Med, Wollongong, NSW 2500, Australia.
   [Batterham, Marijka J.] Univ Wollongong, Fac Engn & Informat Sci, Sch Math & Appl Stat, Stat Consulting Serv, Wollongong, NSW 2522, Australia.
C3 University of Wollongong; Illawarra Health & Medical Research Institute;
   University of Wollongong; Wollongong Hospital; University of Wollongong
RP Neale, EP (corresponding author), Univ Wollongong, Sch Med, Fac Sci Med & Hlth, Wollongong, NSW 2522, Australia.
EM elizan@uow.edu.au
RI Neale, Elizabeth/H-8514-2019; batterham, marijka/IQV-9028-2023; Probst,
   Yasmine/A-1342-2008; Ciarrochi, Joseph/F-5823-2016; Charlton,
   Karen/G-5906-2012
OI Tapsell, Linda/0000-0002-2546-6507; Probst, Yasmine/0000-0002-1971-173X;
   Batterham, Marijka/0000-0002-9520-6508; Russell,
   Joanna/0000-0002-0223-9256; Neale, Elizabeth/0000-0002-6373-8622;
   Ciarrochi, Joseph/0000-0003-0471-8100; Martin,
   Allison/0000-0001-6065-1188; Steel, David/0000-0002-3137-9952; Charlton,
   Karen/0000-0002-8044-444X; McMahon, Anne-Therese/0000-0001-9657-6001;
   Deane, Frank/0000-0002-6247-7416
FU Illawarra Health and Medical Research Institute; California Walnut
   Commission
FX This study was funded by the Illawarra Health and Medical Research
   Institute and the California Walnut Commission. The funding bodies were
   not involved in the analysis and interpretation of data, or writing of
   the report. Illawarra Health and Medical Research Institute facilities
   were used for conducting the study, including the collection of data.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   [Anonymous], 2013, AUSTR DIET GUID
   [Anonymous], 2011, 41020 AUSTR BUR STAT
   [Anonymous], 1379055001 AUSTR BUR
   [Anonymous], AUSTR PHYS ACT SED B
   [Anonymous], NUTR DIET S1
   [Anonymous], MED SCI SPORTS EXERC
   [Anonymous], 2011, 4364055001 ABS
   [Anonymous], HLTH ED BEHAV
   [Anonymous], BEHAV THER
   [Anonymous], POP LEV INT CHAPT 3
   Appel LJ, 2013, NEW ENGL J MED, V368, P1353, DOI 10.1056/NEJMe1301582
   Banks I, 2013, TREND UROL MENS HEAL, V4, P39, DOI 10.1002/tre.357
   Bauer UE, 2014, LANCET, V384, P45, DOI 10.1016/S0140-6736(14)60648-6
   Bond FW, 2011, BEHAV THER, V42, P676, DOI 10.1016/j.beth.2011.03.007
   Bosomworth NJ, 2012, CAN FAM PHYSICIAN, V58, P517
   Brug Johannes, 2005, Int J Behav Nutr Phys Act, V2, P2, DOI 10.1186/1479-5868-2-2
   Cameron AJ, 2007, DIABETES RES CLIN PR, V77, P471, DOI 10.1016/j.diabres.2007.02.002
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   Estruch R, 2013, NEW ENGL J MED, V368, P1279, DOI 10.1056/NEJMoa1200303
   Food Standards Australia New Zealand, 2008, AUSNUT 2007 AUSTR FO
   Ghosh A, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-557
   Glasgow RE, 2007, ANNU REV PUBL HEALTH, V28, P413, DOI 10.1146/annurev.publhealth.28.021406.144145
   Grafenauer SJ, 2014, BRIT J NUTR, V111, P1862, DOI 10.1017/S0007114514000063
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Guh DP, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-88
   Hill JO, 2005, J AM DIET ASSOC, V105, pS63, DOI 10.1016/j.jada.2005.02.016
   Jenkinson C, 2001, J PUBLIC HEALTH MED, V23, P187, DOI 10.1093/pubmed/23.3.187
   Karlsson J, 2000, INT J OBESITY, V24, P1715, DOI 10.1038/sj.ijo.0801442
   Keyes CLM, 2003, POSITIVE PSYCHOLOGICAL ASSESSMENT: HANDBOOK OF MODELS AND MEASURES, P411, DOI 10.1037/10612-026
   Lillis J, 2014, J CONTEXTUAL BEHAV S, V3, P1, DOI 10.1010/j.jcbs.2013.11.005
   Lovibond SH., 1995, Depression Anxiety Stress Scales-Short Form (DASS-21) [Measurement instrument]
   Marfell-Jones M., 2006, ISAK manual: international standards for anthropometric assessment
   Marks G.C., 2001, Monitoring food habits in the Australian population using short questions
   Martin GS, 2003, PREV MED, V36, P420, DOI 10.1016/S0091-7435(02)00054-3
   Moher D, 2010, BMJ-BRIT MED J, V340, DOI [10.1016/j.jclinepi.2010.02.005, 10.1136/bmj.c869, 10.1186/1741-7015-8-18, 10.1016/j.ijsu.2011.10.001, 10.1136/bmj.c332, 10.4103/0976-500X.72352, 10.1186/1745-6215-11-32, 10.1016/j.jclinepi.2010.03.004]
   Mullan E, 1997, PERS INDIV DIFFER, V23, P745, DOI 10.1016/S0191-8869(97)00107-4
   National Health and Medical Research Council, 2013, Clinical practice guidelines for the management of overweight and obesity in adults, adolescents and children in Australia
   Ostbye T, 2011, INT J EPIDEMIOL, V40, P240, DOI 10.1093/ije/dyq142
   Peirson Leslea, 2015, CMAJ Open, V3, pE47, DOI 10.9778/cmajo.20140050
   Ritenbaugh C, 2003, ANN EPIDEMIOL, V13, pS87, DOI 10.1016/S1047-2797(03)00044-9
   Tapsell LC, 2014, EUR J CLIN NUTR, V68, P778, DOI 10.1038/ejcn.2014.39
   Tapsell LC, 2009, EUR J CLIN NUTR, V63, P1008, DOI 10.1038/ejcn.2009.19
   Tapsell L, 2009, J AM COLL NUTR, V28, P611, DOI 10.1080/07315724.2009.10719793
   Tapsell LC, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-1231
   Thomson JL, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-983
   Westenhoefer J, 1999, INT J EAT DISORDER, V26, P53, DOI 10.1002/(SICI)1098-108X(199907)26:1<53::AID-EAT7>3.0.CO;2-N
   Whitlock G, 2009, LANCET, V373, P1083, DOI 10.1016/S0140-6736(09)60318-4
   Wilson PM, 2006, J APPL BIOBEHAV RES, V11, P79, DOI 10.1111/j.1751-9861.2006.tb00021.x
   Young MD, 2014, CONTEMP CLIN TRIALS, V37, P84, DOI 10.1016/j.cct.2013.11.004
NR 50
TC 21
Z9 22
U1 0
U2 13
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1551-7144
EI 1559-2030
J9 CONTEMP CLIN TRIALS
JI Contemp. Clin. Trials
PD NOV
PY 2015
VL 45
BP 394
EP 403
DI 10.1016/j.cct.2015.10.008
PN B
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA DA4FJ
UT WOS:000367755200037
PM 26498404
DA 2025-06-11
ER

PT J
AU Bettaieb, A
   Nagata, N
   AbouBechara, D
   Chahed, S
   Morisseau, C
   Hammock, BD
   Haj, FG
AF Bettaieb, Ahmed
   Nagata, Naoto
   AbouBechara, Daniel
   Chahed, Samah
   Morisseau, Christophe
   Hammock, Bruce D.
   Haj, Fawaz G.
TI Soluble Epoxide Hydrolase Deficiency or Inhibition Attenuates
   Diet-induced Endoplasmic Reticulum Stress in Liver and Adipose Tissue
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID UNFOLDED PROTEIN RESPONSE; ER STRESS; EPOXYEICOSATRIENOIC ACIDS;
   GLUCOSE-HOMEOSTASIS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   BLOOD-PRESSURE; MESSENGER-RNA; CELL-DEATH; OBESITY
AB Soluble epoxide hydrolase (sEH) is a cytosolic enzyme whose inhibition has beneficial effects in cardiovascular, inflammatory, and metabolic diseases in murine models. Mice with targeted deletion or pharmacological inhibition of sEH exhibit improved insulin signaling in liver and adipose tissue. Herein, we assessed the role of sEH in regulating endoplasmic reticulum (ER) stress in liver and adipose tissue. We report that sEH expression was increased in the livers and adipose tissue of mice fed a high fat diet, the adipose tissue of overweight humans, and palmitate-treated cells. Importantly, sEH deficiency or inhibition in mice attenuated chronic high fat diet-induced ER stress in liver and adipose tissue. Similarly, pharmacological inhibition of sEH in HepG2 cells and 3T3-L1 adipocytes mitigated chemical-induced ER stress and activation of JNK, p38, and cell death. In addition, insulin signaling was enhanced in HepG2 cells treated with sEH substrates and attenuated in cells treated with sEH products. In summary, these findings demonstrate that sEH is a physiological modulator of ER stress and a potential target for mitigating complications associated with obesity.
C1 [Bettaieb, Ahmed; Nagata, Naoto; AbouBechara, Daniel; Chahed, Samah; Haj, Fawaz G.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Morisseau, Christophe; Hammock, Bruce D.] Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA.
   [Haj, Fawaz G.] Univ Calif Davis, Dept Internal Med, Davis, CA 95616 USA.
   [Morisseau, Christophe; Hammock, Bruce D.; Haj, Fawaz G.] Univ Calif Davis, Ctr Comprehens Canc, Davis, CA 95616 USA.
C3 University of California System; University of California Davis;
   University of California System; University of California Davis;
   University of California System; University of California Davis;
   University of California System; University of California Davis
RP Haj, FG (corresponding author), Univ Calif Davis, Dept Nutr, 3135 Meyer Hall, Davis, CA 95616 USA.
EM fghaj@ucdavis.edu
RI Nagata, Naoto/D-9261-2012
OI Nagata, Naoto/0000-0002-2389-2334; Morisseau,
   Christophe/0000-0002-5672-6631
FU National Institutes of Health [R56 DK084317, R01 DK090492, ES02710];
   Superfund Basic Research Program from NIEHS [P42 ES04699]; NHLBI
   [HL059699]; Juvenile Diabetes Research Foundation [1-2009-337]
FX This work was supported, in whole or in part, by National Institutes of
   Health Grants R56 DK084317 and R01 DK090492 (to F. G. H.) and by
   National Institutes of Health Grant ES02710 and Superfund Basic Research
   Program Grant P42 ES04699 from NIEHS and Grant HL059699 from NHLBI (to
   B. D. H.). This work was also supported by Juvenile Diabetes Research
   Foundation Research Grant 1-2009-337 (to F. G. H.).
CR Boden G, 2008, DIABETES, V57, P2438, DOI 10.2337/db08-0604
   Burgess A, 2012, PROSTAG OTH LIPID M, V97, P1, DOI 10.1016/j.prostaglandins.2011.10.002
   Calfon M, 2002, NATURE, V415, P92, DOI 10.1038/415092a
   De Taeye BM, 2010, OBESITY, V18, P489, DOI 10.1038/oby.2009.227
   Enayetallah AE, 2004, J HISTOCHEM CYTOCHEM, V52, P447, DOI 10.1177/002215540405200403
   Friedman JM, 2000, NATURE, V404, P632, DOI 10.1038/35007504
   GILL SS, 1980, BIOCHEM PHARMACOL, V29, P389, DOI 10.1016/0006-2952(80)90518-3
   HAMMOCK BD, 1983, TOXICOL APPL PHARM, V71, P254, DOI 10.1016/0041-008X(83)90342-3
   Harding HP, 1999, NATURE, V397, P271, DOI 10.1038/16729
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   Hummasti S, 2010, CIRC RES, V107, P579, DOI 10.1161/CIRCRESAHA.110.225698
   Imig JD, 2002, HYPERTENSION, V39, P690, DOI 10.1161/hy0202.103788
   Imig JD, 2009, NAT REV DRUG DISCOV, V8, P794, DOI 10.1038/nrd2875
   Inceoglu B, 2007, PROSTAG OTH LIPID M, V82, P42, DOI 10.1016/j.prostaglandins.2006.05.004
   Jeffrey KD, 2008, P NATL ACAD SCI USA, V105, P8452, DOI 10.1073/pnas.0711232105
   Jones PD, 2006, BIOORG MED CHEM LETT, V16, P5212, DOI 10.1016/j.bmcl.2006.07.009
   Jurczak MJ, 2012, J BIOL CHEM, V287, P2558, DOI 10.1074/jbc.M111.316760
   Kammoun HL, 2009, J CLIN INVEST, V119, P1201, DOI 10.1172/JCI37007
   Kars M, 2010, DIABETES, V59, P1899, DOI 10.2337/db10-0308
   Kim DH, 2010, STEM CELLS DEV, V19, P1863, DOI 10.1089/scd.2010.0098
   Koh IU, 2010, FEBS J, V277, P2304, DOI 10.1111/j.1742-4658.2010.07646.x
   Kundu S, 2013, J LIPID RES, V54, P436, DOI 10.1194/jlr.M031914
   Latreille M, 2011, AM J PHYSIOL-ENDOC M, V300, pE423, DOI 10.1152/ajpendo.00088.2010
   Liu Y, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039165
   Lowe CE, 2012, INT J OBESITY, V36, P1248, DOI 10.1038/ijo.2011.233
   Luo PC, 2010, J PHARMACOL EXP THER, V334, P430, DOI 10.1124/jpet.110.167544
   Luria A, 2011, P NATL ACAD SCI USA, V108, P9038, DOI 10.1073/pnas.1103482108
   McElroy NR, 2003, J MED CHEM, V46, P1066, DOI 10.1021/jm020269o
   Mensah GA, 2004, CARDIOL CLIN, V22, P485, DOI 10.1016/j.ccl.2004.06.005
   Morisseau C, 1999, P NATL ACAD SCI USA, V96, P8849, DOI 10.1073/pnas.96.16.8849
   Nagata N, 2012, ENDOCRINOLOGY, V153, P3158, DOI 10.1210/en.2012-1406
   Nair S, 2007, TOXICOL LETT, V168, P21, DOI 10.1016/j.toxlet.2006.10.012
   Nakamura T, 2010, CELL, V140, P338, DOI 10.1016/j.cell.2010.01.001
   Nakatani Y, 2005, J BIOL CHEM, V280, P847, DOI 10.1074/jbc.M411860200
   Newman JW, 2005, PROG LIPID RES, V44, P1, DOI 10.1016/j.plipres.2004.10.001
   Nishitoh H, 2002, GENE DEV, V16, P1345, DOI 10.1101/gad.992302
   Node K, 1999, SCIENCE, V285, P1276, DOI 10.1126/science.285.5431.1276
   Novoa I, 2003, EMBO J, V22, P1180, DOI 10.1093/emboj/cdg112
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Okada T, 2002, BIOCHEM J, V366, P585, DOI 10.1042/BJ20020391
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   PINOT F, 1995, BIOCHEM PHARMACOL, V50, P501, DOI 10.1016/0006-2952(95)00167-X
   Ron D, 2007, NAT REV MOL CELL BIO, V8, P519, DOI 10.1038/nrm2199
   Sabio G, 2010, TRENDS BIOCHEM SCI, V35, P490, DOI 10.1016/j.tibs.2010.04.004
   Schmidt-Ott KM, 2005, J AM SOC NEPHROL, V16, P1993, DOI 10.1681/ASN.2004121127
   Schröder M, 2005, ANNU REV BIOCHEM, V74, P739, DOI 10.1146/annurev.biochem.73.011303.074134
   Sha HB, 2009, CELL METAB, V9, P556, DOI 10.1016/j.cmet.2009.04.009
   Sharma NK, 2008, J CLIN ENDOCR METAB, V93, P4532, DOI 10.1210/jc.2008-1001
   Shen HC, 2012, J MED CHEM, V55, P1789, DOI 10.1021/jm201468j
   Shi YG, 1998, MOL CELL BIOL, V18, P7499, DOI 10.1128/MCB.18.12.7499
   Sidrauski C, 1997, CELL, V90, P1031, DOI 10.1016/S0092-8674(00)80369-4
   Sinal CJ, 2000, J BIOL CHEM, V275, P40504, DOI 10.1074/jbc.M008106200
   Spector AA, 2007, AM J PHYSIOL-CELL PH, V292, pC996, DOI 10.1152/ajpcell.00402.2006
   Spiegelman BM, 2001, CELL, V104, P531, DOI 10.1016/S0092-8674(01)00240-9
   Wagner K, 2011, J AGR FOOD CHEM, V59, P2816, DOI 10.1021/jf102559q
   Xiao CT, 2011, DIABETES, V60, P918, DOI 10.2337/db10-1433
   Xu C, 2004, J BIOL CHEM, V279, P17973, DOI 10.1074/jbc.M313263200
   Ye J, 2000, MOL CELL, V6, P1355, DOI 10.1016/S1097-2765(00)00133-7
   Ye RS, 2010, DIABETES, V59, P6, DOI 10.2337/db09-0755
   Yoshida H, 2001, CELL, V107, P881, DOI 10.1016/S0092-8674(01)00611-0
   Zha BS, 2012, BIOCHEM RES INT, V2012, DOI 10.1155/2012/312943
   Zhang KZ, 2011, EMBO J, V30, P1357, DOI 10.1038/emboj.2011.52
   Zhang Y, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-81
   Zhou LJ, 2009, MOL PHARMACOL, V76, P596, DOI 10.1124/mol.109.057067
   Zhou YJ, 2011, NAT MED, V17, P356, DOI 10.1038/nm.2293
   Zinszner H, 1998, GENE DEV, V12, P982, DOI 10.1101/gad.12.7.982
NR 66
TC 108
Z9 123
U1 0
U2 17
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAY 17
PY 2013
VL 288
IS 20
BP 14189
EP 14199
DI 10.1074/jbc.M113.458414
PG 11
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 148OB
UT WOS:000319253500023
PM 23576437
OA Green Published
DA 2025-06-11
ER

PT J
AU Gardea-Resendez, M
   Winham, SJ
   Romo-Nava, F
   Cuellar-Barboza, A
   Clark, MM
   Andreazza, AC
   Cabello-Arreola, A
   Veldic, M
   Bond, DJ
   Singh, B
   Prieto, ML
   Nunez, NA
   Betcher, H
   Moore, KM
   Blom, T
   Colby, C
   Pendegraft, RS
   Kelpin, SS
   Ozerdem, A
   Miola, A
   De Filippis, E
   Biernacka, JM
   McElroy, SL
   Frye, MA
AF Gardea-Resendez, Manuel
   Winham, Stacey J.
   Romo-Nava, Francisco
   Cuellar-Barboza, Alfredo
   Clark, Matthew M.
   Andreazza, Ana Cristina
   Cabello-Arreola, Alejandra
   Veldic, Marin
   Bond, David J.
   Singh, Balwinder
   Prieto, Miguel L.
   Nunez, Nicolas A.
   Betcher, Hannah
   Moore, Katherine M.
   Blom, Thomas
   Colby, Colin
   Pendegraft, Richard S.
   Kelpin, Sydney S.
   Ozerdem, Aysegul
   Miola, Alessandro
   De Filippis, Eleanna
   Biernacka, Joanna M.
   McElroy, Susan L.
   Frye, Mark A.
TI Quantification of diet quality utilizing the rapid eating assessment for
   participants-shortened version in bipolar disorder: Implications for
   prospective depression and cardiometabolic studies
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Bipolar disorder; Diet quality; Cardiometabolic markers; Obesity;
   Bipolar depression
ID METABOLIC SYNDROME; SYMPTOMS; RISK; OBESITY; WOMEN; REAP; SCHIZOPHRENIA;
   VALIDATION; INVENTORY; NUTRITION
AB Objectives: Recognizing bipolar disorder as a multi-system metabolic condition driven, in part, by binge eating behavior and atypical depressive symptoms, this study aimed to quantify diet quality and evaluate clinical correlates in a bipolar disorder cohort. Methods: Participants from the Mayo Clinic Bipolar Disorder Biobank (n = 734) completed the Rapid Eating Assessment for Participants - Shortened version (REAP-S) to determine diet quality. The average REAP-S score for a U.S. omnivorous diet is 32 (range 13 to 39) with higher scores indicating healthier diet. Demographic variables were collected in a standardized clinical questionnaire. Depressive symptoms were assessed by the Bipolar Inventory of Symptoms Scale. Cardiometabolic variables were retrieved from the electronic health record. Associations between continuous variables and REAP-S scores (total, 'healthy foods' and 'avoidance of unhealthy foods') were assessed using linear regression. Results: Overall, our sample had a mean REAP-S score of 27.6 (4.9), suggestive of a lower diet quality than the average general population in the US. There was a significant inverse relationship between mean REAP-S lower scores with increased BMI, waist circumference, disordered eating and depression. All these associations were significantly stronger in female participants. Limitations: EHR cross-sectional data. Conclusions: Our data suggest unhealthy diet quality in bipolar disorder is associated with depression, obesity and cardiometabolic abnormalities. Additional work is encouraged to prospectively track mood and diet quality to further understand the bidirectional relationship and clarify if dietary interventions can positively impact mood. Further delineating potential sex differences in diet quality and depression may provide greater appreciation of modifiable risk factors for future cardiometabolic burden.
C1 [Gardea-Resendez, Manuel; Clark, Matthew M.; Cabello-Arreola, Alejandra; Veldic, Marin; Singh, Balwinder; Prieto, Miguel L.; Nunez, Nicolas A.; Betcher, Hannah; Moore, Katherine M.; Kelpin, Sydney S.; Ozerdem, Aysegul; Biernacka, Joanna M.; Frye, Mark A.] Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA.
   [Winham, Stacey J.; Colby, Colin; Pendegraft, Richard S.; Biernacka, Joanna M.] Mayo Clin, Dept Quantitat Hlth Sci, Rochester, MN USA.
   [Romo-Nava, Francisco; Blom, Thomas; McElroy, Susan L.] Univ Cincinnati, Lindner Ctr HOPE, Dept Psychiat & Behav Neurosci, Coll Med, Mason, OH USA.
   [Cuellar-Barboza, Alfredo] Univ Autonoma Nuevo Leon, Dept Psychiat, Monterrey, Mexico.
   [Andreazza, Ana Cristina] Univ Toronto, Temerty Fac Med, Dept Pharmacol & Toxicol & Psychiat, Toronto, ON, Canada.
   [Bond, David J.] Univ Minnesota, Dept Psychiat & Behav Sci, Med Sch, Minneapolis, MN USA.
   [Prieto, Miguel L.] Univ Andes, Fac Med, Dept Psychiat, Santiago, Chile.
   [Prieto, Miguel L.] Clin Univ Andes, Mental Hlth Serv, Santiago, Chile.
   [Prieto, Miguel L.] Univ Andes, Ctr Biomed Res & Innovat, Santiago, Chile.
   [Miola, Alessandro] Univ Hosp Padova, Dept Neurosci, Psychiat Unit, Padua, Italy.
   [De Filippis, Eleanna] Mayo Clin, Dept Endocrinol, Scottsdale, AZ USA.
   [Frye, Mark A.] Mayo Clin, Dept Psychiat & Psychol, 200 1st St SW, Rochester, MN 55902 USA.
C3 Mayo Clinic; Mayo Clinic; University System of Ohio; University of
   Cincinnati; Universidad Autonoma de Nuevo Leon; University of Toronto;
   University of Minnesota System; University of Minnesota Twin Cities;
   Universidad de los Andes - Chile; Universidad de los Andes - Chile;
   Universidad de los Andes - Chile; University of Padua; Azienda
   Ospedaliera - Universita di Padova; Mayo Clinic; Mayo Clinic Phoenix;
   Mayo Clinic
RP Frye, MA (corresponding author), Mayo Clin, Dept Psychiat & Psychol, 200 1st St SW, Rochester, MN 55902 USA.
EM mfrye@mayo.edu
RI Cuellar-Barboza, Alfredo/A-9278-2015; Singh, Balwinder/H-2016-2011;
   Gardea Resendez, Manuel/LZE-8888-2025; Miola, Alessandro/LMP-0749-2024;
   Nunez, Nicolas/HPD-4606-2023; Veldic, Marin/N-7705-2017; Andreazza, Ana
   Cristina/P-8562-2018
OI Andreazza, Ana Cristina/0000-0002-4323-7273; Gardea Resendez,
   Manuel/0000-0002-9825-8792; Romo-Nava, Francisco/0000-0002-5894-3701;
   OZERDEM, AYSEGUL/0000-0002-9455-5896; Bond, David/0000-0002-8713-7311
CR Akbaraly TN, 2009, BRIT J PSYCHIAT, V195, P408, DOI 10.1192/bjp.bp.108.058925
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   [Anonymous], 2011, DIABETES RES CLIN PR, V93, P299, DOI 10.1016/j.diabres.2011.03.012
   Appelhans BM, 2012, J ACAD NUTR DIET, V112, P693, DOI 10.1016/j.jand.2012.02.006
   Aronica L, 2021, INT J OBESITY, V45, P225, DOI 10.1038/s41366-020-00708-y
   Bly MJ, 2014, BIPOLAR DISORD, V16, P277, DOI 10.1111/bdi.12160
   Bowden CL, 2007, ACTA PSYCHIAT SCAND, V116, P189, DOI 10.1111/j.1600-0447.2006.00955.x
   Cardenas J, 2008, J AFFECT DISORDERS, V106, P91, DOI 10.1016/j.jad.2007.05.030
   CDC, 2019, DEF AD OV OB
   Cuellar-Barboza AB, 2021, J AFFECT DISORDERS, V282, P637, DOI 10.1016/j.jad.2020.12.121
   Darmon N, 2015, NUTR REV, V73, P643, DOI 10.1093/nutrit/nuv027
   Dent R, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0036889, 10.1371/journal.pone.0037135]
   Dregan A, 2020, JAMA PSYCHIAT, V77, P598, DOI 10.1001/jamapsychiatry.2019.4712
   Elmslie JL, 2001, J CLIN PSYCHIAT, V62, P486, DOI 10.4088/JCP.v62n0614
   Elstgeest LEM, 2019, J AFFECT DISORDERS, V249, P394, DOI 10.1016/j.jad.2019.02.004
   Ezzati M, 2017, LANCET, V390, P2627, DOI [10.1016/S0140-6736(17)32129-3, 10.1016/s0140-6736(17)32129-3]
   Foroughi M, 2022, PSYCHOSOM MED, V84, P97, DOI 10.1097/PSY.0000000000001017
   Frye MA, 2015, INT J BIPOLAR DISORD, V3, DOI 10.1186/s40345-015-0030-4
   Frye MA, 2011, NEW ENGL J MED, V364, P51, DOI 10.1056/NEJMcp1000402
   Fürtjes AE, 2022, PSYCHOL MED, V52, P4039, DOI 10.1017/S0033291721000945
   Gans K.M., 2000, Nutrition Clinical Care, V3, P163, DOI DOI 10.1046/J.1523-5408.2000.00045.X
   Gans KM, 2006, J NUTR EDUC BEHAV, V38, P286, DOI 10.1016/j.jneb.2005.12.002
   Gans KM, 2003, J NUTR, V133, p556S, DOI 10.1093/jn/133.2.556S
   Goldstein BI, 2020, BIPOLAR DISORD, V22, P440, DOI 10.1111/bdi.12921
   Gonzalez JM, 2008, INT J METH PSYCH RES, V17, P198, DOI 10.1002/mpr.262
   Guenther PM, 2014, J NUTR, V144, P399, DOI 10.3945/jn.113.183079
   Jacka FN, 2011, J AFFECT DISORDERS, V129, P332, DOI 10.1016/j.jad.2010.09.004
   Johnston CS, 2018, NUTR J, V17, DOI 10.1186/s12937-018-0399-x
   Khan I, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041196
   Korczak DJ, 2022, NUTR NEUROSCI, V25, P1948, DOI 10.1080/1028415X.2021.1918981
   Kuczmarski MF, 2010, J AM DIET ASSOC, V110, P383, DOI 10.1016/j.jada.2009.11.025
   Lassale C, 2019, MOL PSYCHIATR, V24, P965, DOI 10.1038/s41380-018-0237-8
   Leboyer M, 2012, J AFFECT DISORDERS, V141, P1, DOI 10.1016/j.jad.2011.12.049
   Li J, 2020, J AM COLL CARDIOL, V76, P2181, DOI 10.1016/j.jacc.2020.09.535
   Lojko D, 2019, EUR REV MED PHARMACO, V23, P1221, DOI 10.26355/eurrev_201902_17016
   Lutes LD, 2018, CONTEMP CLIN TRIALS, V70, P8, DOI 10.1016/j.cct.2018.04.007
   Ma J, 2010, OBESITY, V18, P347, DOI 10.1038/oby.2009.213
   McAulay C, 2019, J EAT DISORD, V7, DOI 10.1186/s40337-019-0262-2
   McElroy SL, 2016, ACTA PSYCHIAT SCAND, V133, P144, DOI 10.1111/acps.12460
   McElroy SL, 2016, J AFFECT DISORDERS, V201, P95, DOI 10.1016/j.jad.2016.05.003
   Meller FD, 2021, J AFFECT DISORDERS, V282, P1076, DOI 10.1016/j.jad.2020.12.155
   Miller V, 2020, LANCET PLANET HEALTH, V4, pE352, DOI 10.1016/S2542-5196(20)30162-5
   Neufcourt L, 2015, NUTR METAB CARDIOVAS, V25, P988, DOI 10.1016/j.numecd.2015.09.002
   Painold A, 2019, BIPOLAR DISORD, V21, P40, DOI 10.1111/bdi.12682
   Parletta N, 2019, NUTR NEUROSCI, V22, P474, DOI 10.1080/1028415X.2017.1411320
   Prieto ML, 2016, J AFFECT DISORDERS, V194, P120, DOI 10.1016/j.jad.2016.01.015
   Rahe C, 2014, EUR J NUTR, V53, P997, DOI 10.1007/s00394-014-0652-9
   Romo-Nava F, 2020, ACTA PSYCHIAT SCAND, V142, P58, DOI 10.1111/acps.13179
   Segal-Isaacson CJ, 2006, AIDS BEHAV, V10, P659, DOI 10.1007/s10461-006-9115-5
   Segal-Isaacson CJ, 2004, DIABETES EDUCATOR, V30, P774, DOI 10.1177/014572170403000512
   Steardo L, 2019, J AFFECT DISORDERS, V245, P174, DOI 10.1016/j.jad.2018.10.360
   Stice E, 2000, PSYCHOL ASSESSMENT, V12, P123, DOI 10.1037//1040-3590.12.2.123
   Teasdale SB, 2019, BRIT J PSYCHIAT, V214, P251, DOI 10.1192/bjp.2019.20
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
NR 54
TC 9
Z9 9
U1 0
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD AUG 1
PY 2022
VL 310
BP 150
EP 155
DI 10.1016/j.jad.2022.05.037
EA MAY 2022
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 2F6WM
UT WOS:000813048100018
PM 35545158
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Yamada, S
   Kimura, M
   Saito, Y
   Saito, H
AF Yamada, Shoji
   Kimura, Masaki
   Saito, Yoshimasa
   Saito, Hidetsugu
TI Nrf2-mediated anti-oxidant effects contribute to suppression of
   non-alcoholic steatohepatitis-associated hepatocellular carcinoma in
   murine model
SO JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
LA English
DT Article
DE hepatocellular carcinoma; gut microbiota; oxidative stress; anti-oxidant
   effect
ID SIGNIFICANT LIVER FIBROSIS; OXIDATIVE STRESS; GENE-EXPRESSION;
   RISK-FACTORS; METABOLIC SYNDROME; CLINICAL-FEATURES; IMMUNE-RESPONSE;
   NRF2; HEPATOCARCINOGENESIS; INFLAMMATION
AB The exact mechanisms of hepatocellular carcinoma development in non-alcoholic steatohepatitis remain unclear. In this study, we used a new class of high-fat diet, which could induce hepatocellular carcinoma development without the use of general chemical carcinogens or knockout mice. We investigated the correlation between hepatocellular carcinoma and oxidative stress/anti-oxidant effects after depletion of the gut microbiota by treatment with antibiotics. Mice fed with the steatohepatitis-inducing high fat diet (STHD-01) for 41 weeks developed hepatocellular carcinoma. Antibiotic-treatment in mice fed with STHD-01 significantly depleted the gut microbiota and significantly ameliorated liver injury/histology. The tumor numbers of hepatocellular carcinoma were dramatically decreased by the antibiotics-treatment. We analyzed the factors involved in oxidative stress and anti-oxidant effects. Oxidative stress was elevated in mice fed with STHD-01, whereas some anti-oxidant factors were significantly elevated after antibiotics treatment. These results suggest that the gut microbiota is a key factor in improving oxidative stress induced by STHD-01 feeding.
C1 [Yamada, Shoji; Kimura, Masaki; Saito, Yoshimasa; Saito, Hidetsugu] Keio Univ, Fac Pharm, Div Pharmacotherapeut, Minato Ku, 1-5-30 Shibakoen, Tokyo 1058512, Japan.
   [Saito, Yoshimasa; Saito, Hidetsugu] Keio Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan.
C3 Keio University; Keio University
RP Saito, H (corresponding author), Keio Univ, Fac Pharm, Div Pharmacotherapeut, Minato Ku, 1-5-30 Shibakoen, Tokyo 1058512, Japan.; Saito, H (corresponding author), Keio Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan.
EM hsaito@a2.keio.jp
FU Depaitment of Pathology, Keio University school of Medicine; MEXT, Japan
   [JCM1649T]; Keio University Fukuzawa Memorial Fund; Japan Society for
   Promotion of Science [15K09021]; Grants-in-Aid for Scientific Research
   [15K09021] Funding Source: KAKEN
FX I would like to thank Drs. Ken Yamazaki and Michiie Sakamoto, Depaitment
   of Pathology, Keio University school of Medicine, for their generous
   support in analyzing the pathological findings. The Escherichia coli
   JCM1649T genome DNA was provided by the RIKEN BRC through the
   Bio-Resource Project of the MEXT, Japan.This work was supported by Keio
   University Fukuzawa Memorial Fund (to HS) and Grant-in-Aid for
   Scientific Research C (15K09021) from the Japan Society for Promotion of
   Science (to HS). The fund was used to obtain materials.
CR Arata M, 2014, WORLD J DIABETES, V5, P917, DOI 10.4239/wjd.v5.i6.917
   Ascha MS, 2010, HEPATOLOGY, V51, P1972, DOI 10.1002/hep.23527
   Bellentani S, 2000, ANN INTERN MED, V132, P112, DOI 10.7326/0003-4819-132-2-200001180-00004
   Bishayee A, 2011, CARCINOGENESIS, V32, P888, DOI 10.1093/carcin/bgr045
   Briscoe CP, 2003, J BIOL CHEM, V278, P11303, DOI 10.1074/jbc.M211495200
   de Ledinghen V, 2006, J HEPATOL, V45, P592, DOI 10.1016/j.jhep.2006.05.008
   Moraes AD, 2013, HORM METAB RES, V45, P605, DOI 10.1055/s-0033-1343450
   Ejima C, 2016, PHYSIOL REP, V4, DOI 10.14814/phy2.13016
   Faienza MF, 2012, HORM RES PAEDIAT, V78, P158, DOI 10.1159/000342642
   Feng XJ, 2017, BIOCHEM PHARMACOL, V136, P136, DOI 10.1016/j.bcp.2017.04.014
   Gerardi G, 2002, CLIN CHEM LAB MED, V40, P104, DOI 10.1515/CCLM.2002.019
   Hanaki H, 1996, J ANTIBIOT, V49, P402, DOI 10.7164/antibiotics.49.402
   Hibino S, 2014, ONCOGENESIS, V3, DOI 10.1038/oncsis.2014.17
   Huang JS, 2010, AM J PHYSIOL-GASTR L, V299, pG1211, DOI 10.1152/ajpgi.00322.2010
   Imajo K, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0115403
   Inami Y, 2011, J CELL BIOL, V193, P275, DOI 10.1083/jcb.201102031
   Itoh M, 2011, AM J PATHOL, V179, P2454, DOI 10.1016/j.ajpath.2011.07.014
   Kamisako T, 2014, J CLIN BIOCHEM NUTR, V54, P90, DOI 10.3164/jcbn.13-92
   Kinoshita A, 2017, GERIATR GERONTOL INT, V17, P189, DOI 10.1111/ggi.12747
   Liu JM, 2017, FOOD FUNCT, V8, P4042, DOI 10.1039/c7fo00355b
   Loo TM, 2017, CANCER DISCOV, V7, P522, DOI 10.1158/2159-8290.CD-16-0932
   Miyazawa K, 2015, MICROBIOL IMMUNOL, V59, P99, DOI 10.1111/1348-0421.12226
   Oda K, 2015, CLIN J GASTROENTEROL, V8, P1, DOI 10.1007/s12328-014-0548-5
   Ooga T, 2011, MOL BIOSYST, V7, P1217, DOI 10.1039/c0mb00141d
   Paradis V, 2009, HEPATOLOGY, V49, P851, DOI 10.1002/hep.22734
   Ratziu V, 2000, GASTROENTEROLOGY, V118, P1117, DOI 10.1016/S0016-5085(00)70364-7
   Roustan A, 2012, LAB ANIM-UK, V46, P167, DOI 10.1258/la.2012.011115
   Sanyal A, 2010, CURR MED RES OPIN, V26, P2183, DOI 10.1185/03007995.2010.506375
   Serfaty L, 2008, DIABETES METAB, V34, P634, DOI 10.1016/S1262-3636(08)74597-X
   Sugiyama K, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094460
   Takaki Y, 2014, CANCER SCI, V105, P1254, DOI 10.1111/cas.12498
   Tanaka Y, 2008, J PHARMACOL EXP THER, V325, P655, DOI 10.1124/jpet.107.135822
   Thimmulappa RK, 2006, J CLIN INVEST, V116, P984, DOI 10.1172/JCI25790
   Tilg H, 2010, HEPATOLOGY, V52, P1836, DOI 10.1002/hep.24001
   Yamamoto N, 2016, J CLIN BIOCHEM NUTR, V58, P202, DOI 10.3164/jcbn.15-127
   Yates MS, 2009, CARCINOGENESIS, V30, P1024, DOI 10.1093/carcin/bgp100
   Yoshimoto S, 2013, NATURE, V499, P97, DOI 10.1038/nature12347
NR 37
TC 2
Z9 2
U1 1
U2 7
PU JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
PI KYOTO
PA KYOTO PREFECTURAL UNIV MED, GRAD SCH MEDICAL SCIENCE, DEPT MOLECULAR
   GASTROENTEROLOGY & HEPATOLOGY, KYOTO, 602-8566, JAPAN
SN 0912-0009
EI 1880-5086
J9 J CLIN BIOCHEM NUTR
JI J. Clin. Biochem. Nutr.
PD SEP 1
PY 2018
VL 63
IS 2
BP 123
EP 128
DI 10.3164/jcbn.17-125
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GW1MV
UT WOS:000446644600007
PM 30279623
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Lu, Y
   Wang, MX
   Bao, JX
   Chen, DS
   Jiang, H
AF Lu, Yi
   Wang, Meixiang
   Bao, Jiaxin
   Chen, Dashuang
   Jiang, Hao
TI Association between oxidative balance score and metabolic syndrome and
   its components in US adults: a cross-sectional study from NHANES
   2011-2018
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE oxidative balance score (OBS); metabolic syndrome; NHANES; oxidative
   stress; antioxidant
ID STRESS; INFLAMMATION; ANTIOXIDANT; OBESITY; HYPERTENSION; DISEASE
AB Background Metabolic syndrome (MetS) is a global health concern that threatens human well-being. The oxidative balance score (OBS) is a tool to identify the level of oxidative stress that is correlated with MetS risk. However, association between OBS and MetS and its components has not been reported. Methods This cross-sectional study included adult individuals with complete OBS and MetS data from National Health and Nutrition Examination Survey (NHANES) 2011-2018. A weighted logistic regression analysis was conducted to identify the association of the total, dietary, and lifestyle OBS scores with MetS. Subgroup analyses and restricted cubic splines were used to further explore associations. Results In total, 10,025 eligible adult individuals (51.48% were males at a median age of 46 years) were included, with a MetS prevalence of 29.98%. In fully adjusted model, higher total OBS was associated with reduced risk of MetS (Q3 vs. Q1: odds ratio [OR] = 0.57, 95% confidence interval [CI], 0.46-0.71, p < 0.001; Q4 vs. Q1: OR = 0.42, 95% CI, 0.33-0.53, p < 0.001; P for trend <0.001). Significant differences were observed in the relationship between dietary OBS and lifestyle OBS and MetS risk (continuous dietary OBS: OR = 0.97, 95% CI, 0.96-0.98, p < 0.001; continuous lifestyle OBS: OR = 0.61, 95% CI, 0.58-0.64, p < 0.001), as well as negative relationship between total OBS and risk of five MetS components (all p < 0.05). Subgroup analysis showed marital status modified the negative association between OBS and MetS in subgroup analysis (P for interaction = 0.014). Moreover, a nonlinear correlation between OBS and MetS (including its components) was found, further elucidating associations (all p < 0.05). Restricted cubic splines demonstrated not obviously U-shape correlation between OBS and MetS components (elevated triglyceride and blood pressure). Conclusion This study suggests a strong association between the OBS and MetS and its components. Our data indicated that a higher OBS score was correlated with a decreased risk of MetS and its components in a nonlinear manner. Hence, the OBS may serve as an effective marker for identifying individuals with MetS, with a higher score indicating a predominance of more antioxidants.
C1 [Lu, Yi; Wang, Meixiang; Jiang, Hao] Nanjing Med Univ, Affiliated Taizhou Peoples Hosp, Taizhou Sch Clin Med, Dept Cardiol, Taizhou, Peoples R China.
   [Bao, Jiaxin] Nanjing Med Univ, Affiliated Taizhou Peoples Hosp, Taizhou Sch Clin Med, Dept Nephrol, Taizhou, Peoples R China.
   [Chen, Dashuang] Nanjing Med Univ, Affiliated Taizhou Peoples Hosp, Taizhou Sch Clin Med, Dept Gen Med, Taizhou, Peoples R China.
C3 Nanjing Medical University; Nanjing Medical University; Nanjing Medical
   University
RP Jiang, H (corresponding author), Nanjing Med Univ, Affiliated Taizhou Peoples Hosp, Taizhou Sch Clin Med, Dept Cardiol, Taizhou, Peoples R China.
EM jianghao555666@163.com
RI Chen, Dashuang/HTM-8417-2023
CR Albano E, 2006, P NUTR SOC, V65, P278, DOI 10.1079/PNS2006496
   Altamura S, 2021, MOL METAB, V51, DOI 10.1016/j.molmet.2021.101235
   Annor FB, 2015, J AM SOC HYPERTENS, V9, P592, DOI 10.1016/j.jash.2015.05.014
   C R Assumpcao, 2008, Open Biochem J, V2, P108, DOI 10.2174/1874091X00802010108
   Campa Carlo C, 2015, Small GTPases, V6, P71, DOI 10.4161/21541248.2014.989789
   Cho AR, 2023, CLIN NUTR, V42, P1292, DOI 10.1016/j.clnu.2023.06.015
   Depeint F, 2006, CHEM-BIOL INTERACT, V163, P94, DOI 10.1016/j.cbi.2006.04.014
   El Assar M, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23158713
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Franco C, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms232214489
   Furukawa S., 2004, Journal of Clinical Investigation, V114, P1752, DOI 10.1172/JCI21625
   Goodman M, 2007, ANN EPIDEMIOL, V17, P394, DOI 10.1016/j.annepidem.2007.01.034
   Grandl G, 2018, SEMIN IMMUNOPATHOL, V40, P215, DOI 10.1007/s00281-017-0666-5
   Grundy SM, 2006, CURR OPIN CARDIOL, V21, P1, DOI 10.1097/01.hco.0000200416.65370.a0
   Hasani M, 2023, BMC CANCER, V23, DOI 10.1186/s12885-023-11657-w
   Hatami Mehdi, 2016, Chonnam Med J, V52, P201, DOI 10.4068/cmj.2016.52.3.201
   Hernández-Ruiz A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11040774
   Horvath TL, 2009, TRENDS ENDOCRIN MET, V20, P78, DOI 10.1016/j.tem.2008.10.003
   Hurrle S, 2017, BIOMED J, V40, P257, DOI 10.1016/j.bj.2017.06.007
   Johnson Clifford L, 2013, Vital Health Stat 2, P1
   Jomova K, 2011, TOXICOLOGY, V283, P65, DOI 10.1016/j.tox.2011.03.001
   Juan CA, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22094642
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Kattoor AJ, 2017, CURR ATHEROSCLER REP, V19, DOI 10.1007/s11883-017-0678-6
   Kwon YJ, 2023, NUTRIENTS, V15, DOI 10.3390/nu15112497
   Lakkur S, 2015, ATHEROSCLEROSIS, V243, P38, DOI 10.1016/j.atherosclerosis.2015.08.032
   Larsen MK, 2016, MEDICINA-LITHUANIA, V52, P19, DOI 10.1016/j.medici.2016.01.005
   Lee GY, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111614
   Lee JH, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.1066159
   Liu YB, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1276940
   Manna P, 2015, METAB SYNDR RELAT D, V13, P423, DOI 10.1089/met.2015.0095
   Mao ZL, 2021, EUR J NUTR, V60, P3873, DOI 10.1007/s00394-021-02557-5
   Masenga SK, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24097898
   MCGONAGLE KA, 1992, J SOC PERS RELAT, V9, P507, DOI 10.1177/0265407592094003
   Mollahosseini M, 2017, ETHIOP J HEALTH SCI, V27, P401, DOI 10.4314/ejhs.v27i4.11
   Moylan JS, 2007, MUSCLE NERVE, V35, P411, DOI 10.1002/mus.20743
   Noruzi Z, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/5593919
   Otani H, 2011, ANTIOXID REDOX SIGN, V15, P1911, DOI 10.1089/ars.2010.3739
   Padayatty SJ, 2003, J AM COLL NUTR, V22, P18, DOI 10.1080/07315724.2003.10719272
   Park HM, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1226107
   Prasun P, 2020, BBA-MOL BASIS DIS, V1866, DOI 10.1016/j.bbadis.2020.165838
   Robles TF, 2003, PHYSIOL BEHAV, V79, P409, DOI 10.1016/S0031-9384(03)00160-4
   Sangwung P, 2020, ENDOCRINOLOGY, V161, DOI 10.1210/endocr/bqaa017
   Savini I, 2013, INT J MOL SCI, V14, P10497, DOI 10.3390/ijms140510497
   Stahl W, 2003, MOL ASPECTS MED, V24, P345, DOI 10.1016/S0098-2997(03)00030-X
   van der Vaart H, 2004, THORAX, V59, P713, DOI 10.1136/thx.2003.012468
   Wang XY, 2024, CLIN NUTR, V43, P1, DOI 10.1016/j.clnu.2023.11.007
   Wu CL, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1148417
   Zhang W, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/1345071
   Zhao Y, 2023, J TRANSL MED, V21, DOI 10.1186/s12967-023-04491-y
NR 50
TC 15
Z9 15
U1 2
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD MAR 13
PY 2024
VL 11
AR 1375060
DI 10.3389/fnut.2024.1375060
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MB3W2
UT WOS:001191136900001
PM 38544757
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Flamment, M
   Kammoun, HL
   Hainault, I
   Ferré, P
   Foufelle, F
AF Flamment, Melissa
   Kammoun, Helene L.
   Hainault, Isabelle
   Ferre, Pascal
   Foufelle, Fabienne
TI Endoplasmic reticulum stress: a new actor in the development of hepatic
   steatosis
SO CURRENT OPINION IN LIPIDOLOGY
LA English
DT Review
DE endoplasmic reticulum stress; hepatic steatosis; lipogenesis; metabolic
   syndrome
ID ELEMENT-BINDING PROTEIN; INSULIN-RESISTANCE; ER STRESS; GENE-EXPRESSION;
   FATTY-ACIDS; NONALCOHOLIC STEATOHEPATITIS; TRANSCRIPTION FACTOR;
   GLUCOSE-HOMEOSTASIS; LIVER-INJURY; ACTIVATION
AB Purpose of review
   To examine the role of endoplasmic reticulum stress in the regulation of hepatic lipid metabolism and its contribution to the development of hepatic steatosis.
   Recent findings
   Endoplasmic reticulum stress activation has been reported in most models of hepatic steatosis in rodents and humans and its contribution to hepatic fat deposition has been recently documented. The main metabolic pathway affected by endoplasmic reticulum stress is lipogenesis. Endoplasmic reticulum stress activates the proteolytic cleavage of the lipogenic transcription factor sterol regulatory element binding protein-1c leading to the induction of lipogenic enzyme expression. A role for X box-binding protein 1, an endoplasmic reticulum stress-activated transcription factor, has also recently emerged. Endoplasmic reticulum stress, by inhibiting apoB100 secretion, has associated with impaired VLDL secretion. In rodents, treatments with molecular or chemical chaperones that reduce endoplasmic reticulum stress markers have fully demonstrated their efficiency in the treatment of hepatic steatosis.
   Summary
   Manipulating endoplasmic reticulum stress pathway yields encouraging results for the treatment of hepatic steatosis in rodents. However, activation of unfolded protein response is a physiological mechanism, which is particularly important for secretory cells such as hepatocytes and the long-term consequences of such treatments should be cautiously evaluated.
C1 [Foufelle, Fabienne] Ctr Rech Cordeliers, INSERM, UMR S 872, F-75006 Paris, France.
   Univ Paris 06, Paris, France.
C3 Universite Paris Cite; Sorbonne Universite; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Sorbonne Universite
RP Foufelle, F (corresponding author), Ctr Rech Cordeliers, INSERM, UMR S 872, 15 Rue Ecole Med, F-75006 Paris, France.
EM fabienne.foufelle@crc.jussieu.fr
RI Ferre, Pascal/K-1250-2013
OI Ferre, Pascal/0000-0003-0115-7045; FOUFELLE,
   Fabienne/0000-0002-0752-622X
FU INSERM; Agence Nationale de la Recherche [ANR-2005-PCOD-035]; European
   Commission [LSHM-CT- 2004-005272]; Ministere de la Recherche et de
   l'Enseignement superieur; Fondation pour la Recherche Medicale; 'Region
   Ile de France'
FX The present work was supported by grants from INSERM, the Agence
   Nationale de la Recherche (ANR-2005-PCOD-035), Alfediam Takeda and from
   the EXGENESIS Integrated Project Grant LSHM-CT- 2004-005272 funded by
   the European Commission. H. L. K. is a recipient of a doctoral
   fellowship from the Ministere de la Recherche et de l'Enseignement
   superieur and from the Fondation pour la Recherche Medicale. M. F. is
   supported by a postdoctoral grant from the 'Region Ile de France'.
CR Bailly-Maitre B, 2010, J BIOL CHEM, V285, P6198, DOI 10.1074/jbc.M109.056648
   Bécard D, 2001, DIABETES, V50, P2425, DOI 10.2337/diabetes.50.11.2425
   Bobrovnikova-Marjon E, 2008, P NATL ACAD SCI USA, V105, P16314, DOI 10.1073/pnas.0808517105
   Boden G, 2008, DIABETES, V57, P2438, DOI 10.2337/db08-0604
   Bommiasamy H, 2009, J CELL SCI, V122, P1626, DOI 10.1242/jcs.045625
   Borradaile NM, 2006, J LIPID RES, V47, P2726, DOI 10.1194/jlr.M600299-JLR200
   Browning JD, 2004, HEPATOLOGY, V40, P1387, DOI 10.1002/hep.20466
   Buse MG, 2006, AM J PHYSIOL-ENDOC M, V290, pE1, DOI 10.1152/ajpendo.00329.2005
   Cardozo AK, 2005, DIABETES, V54, P452, DOI 10.2337/diabetes.54.2.452
   Charlton N, 2002, HEPATOLOGY, V35, P898, DOI 10.1053/jhep.2002.32527
   Colgan SM, 2007, INT J BIOCHEM CELL B, V39, P1843, DOI 10.1016/j.biocel.2007.05.002
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI23621
   Eizirik DL, 2008, ENDOCR REV, V29, P42, DOI 10.1210/er.2007-0015
   Esfandiari F, 2005, AM J PHYSIOL-GASTR L, V289, pG54, DOI 10.1152/ajpgi.00542.2004
   Ferré P, 2007, HORM RES, V68, P72, DOI 10.1159/000100426
   Giorgi C, 2009, INT J BIOCHEM CELL B, V41, P1817, DOI 10.1016/j.biocel.2009.04.010
   Gregor MF, 2009, DIABETES, V58, P693, DOI 10.2337/db08-1220
   Han KL, 2008, DIABETES, V57, P737, DOI 10.2337/db07-0972
   Harding HP, 2000, MOL CELL, V6, P1099, DOI 10.1016/S1097-2765(00)00108-8
   Higuchi N, 2008, HEPATOL RES, V38, P1122, DOI 10.1111/j.1872-034X.2008.00382.x
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Jo H, 2009, CELL METAB, V9, P440, DOI 10.1016/j.cmet.2009.04.004
   Kammoun HL, 2009, J CLIN INVEST, V119, P1201, DOI 10.1172/JCI37007
   Kharroubi I, 2004, ENDOCRINOLOGY, V145, P5087, DOI 10.1210/en.2004-0478
   Kohjima M, 2007, INT J MOL MED, V20, P351
   Lee AH, 2008, SCIENCE, V320, P1492, DOI 10.1126/science.1158042
   Lee JN, 2004, J BIOL CHEM, V279, P45257, DOI 10.1074/jbc.M408235200
   Lemoine M, 2009, LIVER INT, V29, P1431, DOI 10.1111/j.1478-3231.2009.02022.x
   Lewis GF, 2002, ENDOCR REV, V23, P201, DOI 10.1210/er.23.2.201
   Lim JH, 2009, CELL SIGNAL, V21, P169, DOI 10.1016/j.cellsig.2008.10.004
   Liu J, 2010, J GASTROEN HEPATOL, V25, P613, DOI 10.1111/j.1440-1746.2009.06086.x
   Marchesini G, 2005, CURR OPIN LIPIDOL, V16, P421, DOI 10.1097/01.mol.0000174153.53683.f2
   Mu YP, 2010, LAB INVEST, V90, P245, DOI 10.1038/labinvest.2009.123
   Musso G, 2003, HEPATOLOGY, V37, P909, DOI 10.1053/jhep.2003.50132
   Nakamuta M, 2005, INT J MOL MED, V16, P631
   Neuschwander-Tetri BA, 2003, HEPATOLOGY, V37, P1202, DOI 10.1053/jhep.2003.50193
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Ota T, 2008, J CLIN INVEST, V118, P316, DOI 10.1172/JCI32752
   Oyadomari S, 2008, CELL METAB, V7, P520, DOI 10.1016/j.cmet.2008.04.011
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Puri P, 2008, GASTROENTEROLOGY, V134, P568, DOI 10.1053/j.gastro.2007.10.039
   Qiu W, 2009, J LIPID RES, V50, P1814, DOI 10.1194/jlr.M800343-JLR200
   Rahman SM, 2007, HEPATOLOGY, V45, P1108, DOI 10.1002/hep.21614
   Rutkowski DT, 2008, DEV CELL, V15, P829, DOI 10.1016/j.devcel.2008.10.015
   Sage AT, 2010, AM J PHYSIOL-ENDOC M, V298, pE499, DOI 10.1152/ajpendo.00507.2009
   Sanyal AJ, 2001, GASTROENTEROLOGY, V120, P1183, DOI 10.1053/gast.2001.23256
   Schröder M, 2005, MUTAT RES-FUND MOL M, V569, P29, DOI 10.1016/j.mrfmmm.2004.06.056
   Sharma NK, 2008, J CLIN ENDOCR METAB, V93, P4532, DOI 10.1210/jc.2008-1001
   Shimano H, 1997, J CLIN INVEST, V99, P846, DOI 10.1172/JCI119248
   Shimomura I, 2000, MOL CELL, V6, P77, DOI 10.1016/S1097-2765(00)00009-5
   Shimomura I, 1999, J BIOL CHEM, V274, P30028, DOI 10.1074/jbc.274.42.30028
   Sreejayan N, 2008, OBESITY, V16, P1331, DOI 10.1038/oby.2008.217
   Sreekumar R, 2003, HEPATOLOGY, V38, P244, DOI 10.1053/jhep.2003.50290
   Su QZ, 2009, HEPATOLOGY, V50, P77, DOI 10.1002/hep.22960
   Tarantino G, 2009, EUR J GASTROEN HEPAT, V21, P504, DOI 10.1097/MEG.0b013e3283229b40
   Urano F, 2000, SCIENCE, V287, P664, DOI 10.1126/science.287.5453.664
   Wang D, 2006, ENDOCRINOLOGY, V147, P943, DOI 10.1210/en.2005-0570
   Watanabe Y, 2003, J CELL BIOCHEM, V89, P244, DOI 10.1002/jcb.10501
   Wei YR, 2006, AM J PHYSIOL-ENDOC M, V291, pE275, DOI 10.1152/ajpendo.00644.2005
   Wei YR, 2009, MOL CELL BIOCHEM, V331, P31, DOI 10.1007/s11010-009-0142-1
   Werstuck GH, 2001, J CLIN INVEST, V107, P1263, DOI 10.1172/JCI11596
   Yahagi N, 2002, J BIOL CHEM, V277, P19353, DOI 10.1074/jbc.M201584200
   Yang L, 2007, LAB INVEST, V87, P927, DOI 10.1038/labinvest.3700603
   Ye J, 2000, MOL CELL, V6, P1355, DOI 10.1016/S1097-2765(00)00133-7
   Zhou QG, 2009, AM J PHYSIOL-ENDOC M, V296, pE869, DOI 10.1152/ajpendo.91011.2008
NR 66
TC 56
Z9 64
U1 3
U2 39
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0957-9672
EI 1473-6535
J9 CURR OPIN LIPIDOL
JI Curr. Opin. Lipidology
PD JUN
PY 2010
VL 21
IS 3
BP 239
EP 246
DI 10.1097/MOL.0b013e3283395e5c
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Peripheral
   Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Cardiovascular System & Cardiology
GA 601ZG
UT WOS:000278106300011
PM 20463471
DA 2025-06-11
ER

PT J
AU Tamashiro, KL
   Sakai, RR
   Shively, CA
   Karatsoreos, IN
   Reagan, LP
AF Tamashiro, K. L.
   Sakai, R. R.
   Shively, C. A.
   Karatsoreos, I. N.
   Reagan, L. P.
TI Chronic stress, metabolism, and metabolic syndrome
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Review
DE Cardiovascular disease; circadian disruption; diabetes mellitus;
   glucocorticoids; obesity; social stress
ID CHRONIC SOCIAL STRESS; INSULIN-STIMULATED TRANSLOCATION; BODY-WEIGHT;
   SUBORDINATION STRESS; DOWN-REGULATION; DIABETIC-RATS; SHIFT WORK; MODEL;
   OBESITY; CORTICOSTERONE
AB The prevalence of obesity has rapidly escalated and now represents a major public health concern. Although genetic associations with obesity and related metabolic disorders such as diabetes and cardiovascular disease have been identified, together they account for a small proportion of the incidence of disease. Environmental influences such as chronic stress, behavioral and metabolic disturbances, dietary deficiency, and infection have now emerged as contributors to the development of metabolic disease. Although epidemiological data suggest strong associations between chronic stress exposure and metabolic disease, the etiological mechanisms responsible remain unclear. Mechanistic studies of the influence of chronic social stress are now being conducted in both rodent and nonhuman primate models, and phenotypic results are consistent with those in humans. The advantage of these models is that potential neural mechanisms may be examined and interventions to treat or prevent disease may be developed and tested. Further, circadian disruption and metabolic conditions such as diabetes mellitus could increase susceptibility to other stressors or serve as a stressor itself. Here, we review data from leading investigators discussing the interrelationship between chronic stress and development of metabolic disorders.
C1 [Tamashiro, K. L.] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA.
   [Sakai, R. R.] Univ Cincinnati, Coll Med, Dept Psychiat & Behav Sci, Cincinnati, OH USA.
   [Shively, C. A.] Wake Forest Univ, Ctr Primate, Dept Pathol Comparat Med, Winston Salem, NC 27109 USA.
   [Karatsoreos, I. N.] Rockefeller Univ, Neuroendocrinol Lab, New York, NY 10021 USA.
   [Reagan, L. P.] Univ S Carolina, Sch Med, Dept Pharmacol Physiol & Neurosci, Columbia, SC USA.
C3 Johns Hopkins University; University System of Ohio; University of
   Cincinnati; Wake Forest University; Rockefeller University; University
   of South Carolina System; University of South Carolina Columbia
RP Tamashiro, KL (corresponding author), Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 720 Rutland Ave,Ross 618, Baltimore, MD 21205 USA.
EM ktamashiro@jhmi.edu
RI Karatsoreos, Ilia/AAR-8774-2020; Shively, Carol/L-2921-2019
OI Tamashiro, Kellie/0000-0002-9398-8796
FU NIMH [R13MH090623]
FX We acknowledge grant support from NIMH R13MH090623.
CR Balsalobre A, 2000, SCIENCE, V289, P2344, DOI 10.1126/science.289.5488.2344
   Bechtold DA, 2010, TRENDS PHARMACOL SCI, V31, P191, DOI 10.1016/j.tips.2010.01.002
   Björntorp P, 2000, NUTRITION, V16, P924, DOI 10.1016/S0899-9007(00)00422-6
   Björntorp P, 2000, BRIT J NUTR, V83, pS49, DOI 10.1017/S0007114500000957
   BLANCHARD DC, 1995, PSYCHONEUROENDOCRINO, V20, P117, DOI 10.1016/0306-4530(94)E0045-B
   BLANCHARD DC, 1993, BEHAV BRAIN RES, V58, P113, DOI 10.1016/0166-4328(93)90096-9
   BLANCHARD DC, 1990, NEUROSCI BIOBEHAV R, V14, P455, DOI 10.1016/S0149-7634(05)80068-5
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   Brunner EJ, 2007, AM J EPIDEMIOL, V165, P828, DOI 10.1093/aje/kwk058
   CLARKSON TB, 1995, PROG CARDIOVASC DIS, V38, P189, DOI 10.1016/S0033-0620(95)80011-5
   Clarkson TB, 2007, MENOPAUSE, V14, P373, DOI 10.1097/GME.0b013e31803c764d
   Dallman MF, 2010, TRENDS ENDOCRIN MET, V21, P159, DOI 10.1016/j.tem.2009.10.004
   Davis JF, 2009, NEUROSCIENCE, V162, P23, DOI 10.1016/j.neuroscience.2009.04.039
   de Kloet ER, 2007, NAT CLIN PRACT ENDOC, V3, P168, DOI 10.1038/ncpendmet0403
   DENICOLA AF, 1976, HORM METAB RES, V8, P388, DOI 10.1055/s-0028-1093620
   Finkelstein EA, 2009, HEALTH AFFAIR, V28, pW822, DOI 10.1377/hlthaff.28.5.w822
   Gispen WH, 2000, TRENDS NEUROSCI, V23, P542, DOI 10.1016/S0166-2236(00)01656-8
   Grillo CA, 2007, PHYSIOL BEHAV, V92, P691, DOI 10.1016/j.physbeh.2007.05.043
   Grillo CA, 2009, BRAIN RES, V1296, P35, DOI 10.1016/j.brainres.2009.08.005
   Grillo CA, 2005, NEUROSCIENCE, V136, P477, DOI 10.1016/j.neuroscience.2005.08.019
   Grillo CA, 2011, BEHAV BRAIN RES, V222, P230, DOI 10.1016/j.bbr.2011.03.052
   Grillo CA, 2011, PHYSIOL BEHAV, V104, P235, DOI 10.1016/j.physbeh.2010.10.020
   Harvey J, 2006, PROG LIPID RES, V45, P369, DOI 10.1016/j.plipres.2006.03.001
   Hastings MH, 2003, NAT REV NEUROSCI, V4, P649, DOI 10.1038/nrn1177
   Karatsoreos IN, 2011, P NATL ACAD SCI USA, V108, P1657, DOI 10.1073/pnas.1018375108
   Karatsoreos IN, 2010, ENDOCRINOLOGY, V151, P2117, DOI 10.1210/en.2009-1436
   Kuo LE, 2007, PEPTIDES, V28, P435, DOI 10.1016/j.peptides.2006.08.035
   Kuo LE, 2008, ANN NY ACAD SCI, V1148, P232, DOI 10.1196/annals.1410.035
   LEEDOM LJ, 1987, PHYSIOL BEHAV, V40, P447, DOI 10.1016/0031-9384(87)90029-1
   Magariños AM, 2000, P NATL ACAD SCI USA, V97, P11056, DOI 10.1073/pnas.97.20.11056
   McEwen BS, 2004, EUR J PHARMACOL, V490, P13, DOI 10.1016/j.ejphar.2004.02.041
   McKittrick CR, 2000, SYNAPSE, V36, P85, DOI 10.1002/(SICI)1098-2396(200005)36:2<85::AID-SYN1>3.3.CO;2-P
   Melhorn SJ, 2010, AM J PHYSIOL-REG I, V299, pR813, DOI 10.1152/ajpregu.00820.2009
   Nguyen MMN, 2007, ENDOCRINOLOGY, V148, P6145, DOI 10.1210/en.2007-0471
   Niedhammer I, 1996, INT J OBESITY, V20, P625
   Piroli GG, 2007, NEUROENDOCRINOLOGY, V85, P71, DOI 10.1159/000101694
   PLOTSKY PM, 1992, ENDOCRINOLOGY, V130, P1931, DOI 10.1210/en.130.4.1931
   Reagan LP, 2008, EUR J PHARMACOL, V585, P64, DOI 10.1016/j.ejphar.2008.02.050
   Reagan LP, 2002, INT REV NEUROBIOL, V51, P289, DOI 10.1016/S0074-7742(02)51009-6
   REAGAN LP, 2011, EXP NEUROL      0212
   Revsin Y, 2009, NEUROPSYCHOPHARMACOL, V34, P747, DOI 10.1038/npp.2008.136
   Saltiel AR, 2002, TRENDS CELL BIOL, V12, P65, DOI 10.1016/S0962-8924(01)02207-3
   SCRIBNER KA, 1993, ENDOCRINOLOGY, V133, P2667, DOI 10.1210/en.133.6.2667
   SCRIBNER KA, 1991, ENDOCRINOLOGY, V129, P99, DOI 10.1210/endo-129-1-99
   Shively CA, 1998, BIOL PSYCHIAT, V44, P882, DOI 10.1016/S0006-3223(97)00437-X
   SHIVELY CA, 1991, AM J PRIMATOL, V23, P239, DOI 10.1002/ajp.1350230404
   Shively CA, 2009, AM J PRIMATOL, V71, P715, DOI 10.1002/ajp.20720
   Steptoe A, 2002, EUR HEART J, V23, P1757, DOI 10.1053/euhj.2001.3233
   Stranahan AM, 2008, NEUROBIOL LEARN MEM, V90, P479, DOI 10.1016/j.nlm.2008.05.005
   Stranahan AM, 2008, NAT NEUROSCI, V11, P309, DOI 10.1038/nn2055
   Suwazono Y, 2008, HYPERTENSION, V52, P581, DOI 10.1161/HYPERTENSIONAHA.108.114553
   Suwazono Y, 2008, OBESITY, V16, P1887, DOI 10.1038/oby.2008.298
   Tamashiro KLK, 2007, PHYSIOL BEHAV, V91, P440, DOI 10.1016/j.physbeh.2007.04.004
   Tamashiro KLK, 2007, AM J PHYSIOL-REG I, V293, pR1864, DOI 10.1152/ajpregu.00371.2007
   Tamashiro KLK, 2006, PHYSIOL BEHAV, V89, P536, DOI 10.1016/j.physbeh.2006.05.026
   Tamashiro KLK, 2004, PHYSIOL BEHAV, V80, P683, DOI 10.1016/j.physbeh.2003.12.002
   Winocur G, 2005, BEHAV NEUROSCI, V119, P1389, DOI 10.1037/0735-7044.119.5.1389
   WOODS SC, 1979, NATURE, V282, P503, DOI 10.1038/282503a0
NR 58
TC 138
Z9 159
U1 0
U2 48
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1025-3890
EI 1607-8888
J9 STRESS
JI Stress
PD SEP
PY 2011
VL 14
IS 5
BP 468
EP 474
DI 10.3109/10253890.2011.606341
PG 7
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA 808VC
UT WOS:000294008400002
PM 21848434
DA 2025-06-11
ER

PT J
AU Ge, XM
   Liu, Z
   Qi, W
   Shi, XL
   Zhai, QW
AF Ge, Xuemei
   Liu, Zhen
   Qi, Wei
   Shi, Xianglin
   Zhai, Qiwei
TI Chromium (VI) induces insulin resistance in 3T3-L1 adipocytes through
   elevated reactive oxygen species generation
SO FREE RADICAL RESEARCH
LA English
DT Article
DE Cr(VI); insulin resistance; ROS; ER stress; JNK
ID INCREASED OXIDATIVE STRESS; HYDROXYL RADICAL FORMATION; PROTEIN-KINASE
   B; MITOCHONDRIAL DYSFUNCTION; ENDOPLASMIC-RETICULUM;
   SIGNAL-TRANSDUCTION; METABOLIC SYNDROME; HYDROGEN-PEROXIDE; ER STRESS;
   INFLAMMATION
AB Reactive oxygen species (ROS) have been proposed to be involved in the development of insulin resistance, although the exact molecular link between ROS and insulin resistance remains to be determined. Chromium (Cr(VI)) is known as an inducer of ROS. Therefore, this study examined whether Cr(VI) could induce insulin resistance. It demonstrated that Cr(VI) treatment significantly inhibited insulin-stimulated glucose uptake and attenuated insulin signalling. Moreover, Cr(VI) treatment markedly increased the intracellular levels of superoxide anion, hydrogen peroxide and hydroxyl radical. N-acetylcysteine, superoxide dismutase and catalase can block the ROS generation and alleviate the insulin resistance induced by Cr(VI) treatment. In addition, Cr(VI) treatment induced endoplasmic reticulum (ER) stress and JNK activation and these effects were diminished by N-acetylcysteine. These results suggested that ROS generation through Cr(VI) treatment cause ER stress, JNK activation and insulin resistance in adipocytes. Therefore, the oxidative stress could be a potential interventional target for insulin-resistance related diseases.
C1 [Ge, Xuemei; Liu, Zhen; Qi, Wei; Shi, Xianglin; Zhai, Qiwei] Chinese Acad Sci, Key Lab Nutr & Metab, Shanghai Inst Biol Sci, Inst Nutr Sci,Grad Sch, Shanghai 200031, Peoples R China.
C3 Chinese Academy of Sciences
RP Zhai, QW (corresponding author), Chinese Acad Sci, Key Lab Nutr & Metab, Shanghai Inst Biol Sci, Inst Nutr Sci,Grad Sch, 294 Taiyuan Rd, Shanghai 200031, Peoples R China.
EM qwzhai@sibs.ac.cn
RI Shi, Xianglin/B-8588-2012
OI Zhai, Qiwei/0000-0002-9617-7403
CR Arkan MC, 2005, NAT MED, V11, P191, DOI 10.1038/nm1185
   Bedard K, 2007, PHYSIOL REV, V87, P245, DOI 10.1152/physrev.00044.2005
   CARTER WO, 1994, J LEUKOCYTE BIOL, V55, P253
   Dandona P, 2004, TRENDS IMMUNOL, V25, P4, DOI 10.1016/j.it.2003.10.013
   Devangelio E, 2007, FREE RADICAL BIO MED, V43, P511, DOI 10.1016/j.freeradbiomed.2007.03.015
   Evans JL, 2002, ENDOCR REV, V23, P599, DOI 10.1210/er.2001-0039
   Evans JL, 2005, ANTIOXID REDOX SIGN, V7, P1040, DOI 10.1089/ars.2005.7.1040
   Festa A, 2003, CIRCULATION, V108, P1822, DOI 10.1161/01.CIR.0000091339.70120.53
   Fortuño A, 2006, DIABETES, V55, P209, DOI 10.2337/diabetes.55.1.209
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gabriely I, 2002, DIABETES, V51, P2951, DOI 10.2337/diabetes.51.10.2951
   Gregor MF, 2007, J LIPID RES, V48, P1905, DOI 10.1194/jlr.R700007-JLR200
   Haber CA, 2003, AM J PHYSIOL-ENDOC M, V285, pE744, DOI 10.1152/ajpendo.00355.2002
   HAYES RB, 1988, SCI TOTAL ENVIRON, V71, P331, DOI 10.1016/0048-9697(88)90205-7
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Hotamisligil GS, 2005, DIABETES, V54, pS73, DOI 10.2337/diabetes.54.suppl_2.S73
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Kahn SE, 2003, DIABETOLOGIA, V46, P3, DOI 10.1007/s00125-002-1009-0
   Kamata H, 2005, CELL, V120, P649, DOI 10.1016/j.cell.2004.12.041
   Kaneto H, 2005, J MOL MED, V83, P429, DOI 10.1007/s00109-005-0640-x
   Kaneto H, 2004, NAT MED, V10, P1128, DOI 10.1038/nm1111
   Kaneto Hideaki, 2004, Rev Diabet Stud, V1, P165, DOI 10.1900/RDS.2004.1.165
   Katsuki A, 2006, DIABETES RES CLIN PR, V73, P310, DOI 10.1016/j.diabres.2006.02.014
   Kowluru RA, 2006, FREE RADICAL BIO MED, V41, P1191, DOI 10.1016/j.freeradbiomed.2006.01.012
   LEES PSJ, 1991, ENVIRON HEALTH PERSP, V92, P93, DOI 10.2307/3431144
   Mahadev K, 2004, MOL CELL BIOL, V24, P1844, DOI 10.1128/MCB.24.5.1844-1854.2004
   Natali A, 2006, DIABETES, V55, P1133, DOI 10.2337/diabetes.55.04.06.db05-1076
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Petersen KF, 2004, NEW ENGL J MED, V350, P664, DOI 10.1056/NEJMoa031314
   Petersen KF, 2003, SCIENCE, V300, P1140, DOI 10.1126/science.1082889
   Peterson-Roth E, 2005, MOL CELL BIOL, V25, P3596, DOI 10.1128/MCB.25.9.3596-3607.2005
   Rudich A, 1997, AM J PHYSIOL-ENDOC M, V272, pE935, DOI 10.1152/ajpendo.1997.272.5.E935
   Rudich A, 1999, DIABETOLOGIA, V42, P949, DOI 10.1007/s001250051253
   Schrauwen P, 2007, P NUTR SOC, V66, P33, DOI 10.1017/S0029665107005277
   Shi XL, 1999, J TOXICOL ENV HEAL B, V2, P87, DOI 10.1080/109374099281241
   SHI XL, 1989, BIOCHEM BIOPH RES CO, V163, P627, DOI 10.1016/0006-291X(89)92183-9
   SHI XL, 1990, ARCH BIOCHEM BIOPHYS, V277, P342, DOI 10.1016/0003-9861(90)90589-Q
   Shoelson SE, 2007, GASTROENTEROLOGY, V132, P2169, DOI 10.1053/j.gastro.2007.03.059
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Sun C, 2007, CELL METAB, V6, P307, DOI 10.1016/j.cmet.2007.08.014
   Tirosh A, 1999, J BIOL CHEM, V274, P10595, DOI 10.1074/jbc.274.15.10595
   Van Gaal LF, 2006, NATURE, V444, P875, DOI 10.1038/nature05487
   Vianna CR, 2006, CELL METAB, V4, P453, DOI 10.1016/j.cmet.2006.11.003
   Wang SW, 2004, MOL CELL BIOCHEM, V255, P119, DOI 10.1023/B:MCBI.0000007268.42733.53
   Wang SW, 2000, AM J PHYSIOL-CELL PH, V279, pC868, DOI 10.1152/ajpcell.2000.279.3.C868
   Ye JP, 1999, J BIOL CHEM, V274, P34974, DOI 10.1074/jbc.274.49.34974
   YKIJARVINEN H, 1992, ENDOCR REV, V13, P415, DOI 10.1210/er.13.3.415
NR 47
TC 11
Z9 11
U1 0
U2 6
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PY 2008
VL 42
IS 6
BP 554
EP 563
DI 10.1080/10715760802155113
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 317XV
UT WOS:000257054600003
PM 18569013
DA 2025-06-11
ER

PT J
AU Lejawa, M
   Osadnik, K
   Osadnik, T
   Pawlas, N
AF Lejawa, Mateusz
   Osadnik, Kamila
   Osadnik, Tadeusz
   Pawlas, Natalia
TI Association of Metabolically Healthy and Unhealthy Obesity Phenotypes
   with Oxidative Stress Parameters and Telomere Length in Healthy Young
   Adult Men. Analysis of the MAGNETIC Study
SO ANTIOXIDANTS
LA English
DT Article
DE metabolically healthy obesity; metabolically unhealthy obesity;
   oxidative stress; telomere length
ID CARDIOVASCULAR-DISEASE; DIABETIC COMPLICATIONS; INSULIN-RESISTANCE;
   PERSPECTIVE; ANTIOXIDANT; MECHANISM; WEIGHT; PLASMA; IMPACT; WOMEN
AB Obesity is a significant factor related to metabolic disturbances that can lead to metabolic syndrome (MetS). Metabolic dysregulation causes oxidative stress, which affects telomere structure. The current study aimed to evaluate the relationships between telomere length, oxidative stress and the metabolically healthy and unhealthy phenotypes in healthy young men. Ninety-eight participants were included in the study (49 healthy slim and 49 obese patients). Study participants were divided into three subgroups according to body mass index and metabolic health. Selected oxidative stress markers were measured in serum. Relative telomere length (rTL) was measured using quantitative polymerase chain reaction. The analysis showed associations between laboratory markers, oxidative stress markers and rTL in metabolically healthy and unhealthy participants. Total oxidation status (TOS), total antioxidant capacity (TAC) and rTL were significantly connected with metabolically unhealthy obesity. TAC was associated with metabolically healthy obesity. Telomeres shorten in patients with metabolic dysregulation related to oxidative stress and obesity linked to MetS. Further studies among young metabolically healthy and unhealthy individuals are needed to determine the pathways related to metabolic disturbances that cause oxidative stress that leads to MetS.
C1 [Lejawa, Mateusz; Osadnik, Kamila; Osadnik, Tadeusz; Pawlas, Natalia] Fac Med Sci Zabrze, Dept Pharmacol, Jordana 38, PL-41808 Zabrze, Poland.
   [Lejawa, Mateusz; Osadnik, Kamila; Osadnik, Tadeusz; Pawlas, Natalia] Med Univ Silesia, PL-40055 Katowice, Poland.
   [Osadnik, Tadeusz] Silesian Ctr Heart Dis, Dept Cardiol & Angiol 2, Marii Sklodowskiej Curie 9, PL-41800 Zabrze, Poland.
C3 Medical University of Silesia; Silesian Center for Heart Diseases
RP Lejawa, M (corresponding author), Fac Med Sci Zabrze, Dept Pharmacol, Jordana 38, PL-41808 Zabrze, Poland.; Lejawa, M (corresponding author), Med Univ Silesia, PL-40055 Katowice, Poland.
EM mateusz.lejawa@sum.edu.pl; kosadnik@sum.edu.pl;
   tadeusz.osadnik@sum.edu.pl; natalia.pawlas@sum.edu.pl
RI ; Osadnik, Tadeusz/P-5844-2014; Pawlas, Natalia/H-5796-2013
OI Lejawa, Mateusz/0000-0002-1228-7534; Osadnik,
   Tadeusz/0000-0002-3202-6972; Osadnik, Kamila/0000-0002-4618-9844;
   Pawlas, Natalia/0000-0002-7551-9371
FU National Science Centre [UMO-2014113IBINZ5/03166]; Medical University of
   Silesia [KNW-1-039/N/8/K]
FX The study was supported by the National Science Centre (Grant No.
   UMO-2014113IBINZ5/03166, OPUS 7) and Medical University of Silesia
   (Grant No. KNW-1-039/N/8/K).
CR Abolnezhadian F, 2020, VASC HEALTH RISK MAN, V16, P249, DOI 10.2147/VHRM.S251927
   Aizawa K, 2009, DIABETES VASC DIS RE, V6, P181, DOI 10.1177/1479164109336375
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   André P, 2006, DIABETOLOGIA, V49, P2599, DOI 10.1007/s00125-006-0418-x
   Arab K, 2004, ANAL BIOCHEM, V325, P158, DOI 10.1016/j.ab.2003.10.022
   Armanios M, 2009, ANNU REV GENOM HUM G, V10, P45, DOI 10.1146/annurev-genom-082908-150046
   Baynes JW, 1999, DIABETES, V48, P1, DOI 10.2337/diabetes.48.1.1
   BAYNES JW, 1991, DIABETES, V40, P405, DOI 10.2337/diabetes.40.4.405
   BLACKBURN EH, 1991, NATURE, V350, P569, DOI 10.1038/350569a0
   Blüher M, 2019, NAT REV ENDOCRINOL, V15, P288, DOI 10.1038/s41574-019-0176-8
   Brownlee M, 2005, DIABETES, V54, P1615, DOI 10.2337/diabetes.54.6.1615
   Cawthon RM, 2002, NUCLEIC ACIDS RES, V30, DOI 10.1093/nar/30.10.e47
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Ceriello A, 2000, METABOLISM, V49, P27, DOI 10.1016/S0026-0495(00)80082-7
   Chen JH, 2013, ARTHRIT CARE RES, V65, P133, DOI 10.1002/acr.21824
   Chen RQ, 2020, HEART, V106, P267, DOI 10.1136/heartjnl-2019-315629
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Core Team R, The R project for statistical computing
   Dandona P, 2001, J CLIN ENDOCR METAB, V86, P3257, DOI 10.1210/jc.86.7.3257
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   de Mello AH, 2018, LIFE SCI, V192, P26, DOI 10.1016/j.lfs.2017.11.019
   Demanelis K, 2020, SCIENCE, V369, P1333, DOI 10.1126/science.aaz6876
   Doumatey AP, 2016, OBESITY, V24, P1257, DOI 10.1002/oby.21482
   Epel ES, 2006, PSYCHONEUROENDOCRINO, V31, P277, DOI 10.1016/j.psyneuen.2005.08.011
   Erel O, 2004, CLIN BIOCHEM, V37, P277, DOI 10.1016/j.clinbiochem.2003.11.015
   Erel O, 2005, CLIN BIOCHEM, V38, P1103, DOI 10.1016/j.clinbiochem.2005.08.008
   Fortuño A, 2006, DIABETES, V55, P209, DOI 10.2337/diabetes.55.1.209
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gardner JP, 2005, CIRCULATION, V111, P2171, DOI 10.1161/01.CIR.0000163550.70487.0B
   Giral P, 2008, ARTERIOSCL THROM VAS, V28, P587, DOI 10.1161/ATVBAHA.107.157891
   Giral P, 2010, ATHEROSCLEROSIS, V210, P607, DOI 10.1016/j.atherosclerosis.2009.12.026
   Gonçalves CG, 2016, NUTRITION, V32, P14, DOI 10.1016/j.nut.2015.07.010
   Hamer M, 2012, J CLIN ENDOCR METAB, V97, P2482, DOI 10.1210/jc.2011-3475
   Han TS, 2018, INT J OBESITY, V42, P1336, DOI 10.1038/s41366-018-0074-5
   Houben JMJ, 2008, FREE RADICAL BIO MED, V44, P235, DOI 10.1016/j.freeradbiomed.2007.10.001
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Molli AEI, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0174945
   Karelis A, 2004, DIABETES METAB, V30, P569, DOI 10.1016/S1262-3636(07)70156-8
   Kawanishi S, 2004, ANN NY ACAD SCI, V1019, P278, DOI 10.1196/annals.1297.047
   Kim M, 2013, METABOLISM, V62, P554, DOI 10.1016/j.metabol.2012.10.006
   KOSTER JF, 1986, ANN RHEUM DIS, V45, P44, DOI 10.1136/ard.45.1.44
   Liguori I, 2018, CLIN INTERV AGING, V13, P757, DOI 10.2147/CIA.S158513
   Lim JS, 2004, FREE RADICAL BIO MED, V37, P1018, DOI 10.1016/j.freeradbiomed.2004.06.032
   Yubero-Serrano EM, 2013, EXP MOL MED, V45, DOI 10.1038/emm.2013.53
   Marseglia L, 2015, INT J MOL SCI, V16, P378, DOI 10.3390/ijms16010378
   Martínez-Ezquerro JD, 2019, REV INVEST CLIN, V71, P393, DOI [10.24875/RIC.19003116, 10.24875/ric.19003116]
   Mikolajczyk A., 2015, ENV MED, V18, P7
   Navarro E, 2015, MOL NUTR FOOD RES, V59, P75, DOI 10.1002/mnfr.201400521
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   Osadnik K, 2020, DIABET METAB SYND OB, V13, P1281, DOI 10.2147/DMSO.S232497
   Osadnik K, 2020, NUTR J, V19, DOI 10.1186/s12937-020-00532-0
   Osadnik T, 2019, ARCH MED SCI, V15, P590, DOI 10.5114/aoms.2018.75895
   OYANAGUI Y, 1984, ANAL BIOCHEM, V142, P290
   Primeau V, 2011, INT J OBESITY, V35, P971, DOI 10.1038/ijo.2010.216
   Rey-López JP, 2014, OBES REV, V15, P781, DOI 10.1111/obr.12198
   Richterich R., 1971, CHEMIA KLINICZNA TEO
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Rospleszcz S, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-57459-z
   Samocha-Bonet D, 2014, OBES REV, V15, P697, DOI 10.1111/obr.12199
   Speakman JR, 2011, DIS MODEL MECH, V4, P733, DOI 10.1242/dmm.008698
   Stekhoven DJ, 2012, BIOINFORMATICS, V28, P112, DOI 10.1093/bioinformatics/btr597
   STOCKER R, 1987, SCIENCE, V235, P1043, DOI 10.1126/science.3029864
   Stranges S, 2004, HEPATOLOGY, V39, P754, DOI 10.1002/hep.20149
   Tan CY, 2008, BIOCHEM SOC T, V36, P935, DOI 10.1042/BST0360935
   Tian R, 2017, MED SCI MONITOR, V23, P4382, DOI 10.12659/MSM.902106
   TSUCHIDA M, 1985, BIOCHIM BIOPHYS ACTA, V834, P196
   Willeit P, 2010, ARTERIOSCL THROM VAS, V30, P1649, DOI 10.1161/ATVBAHA.110.205492
   Yan LJ, 2014, J DIABETES RES, V2014, DOI 10.1155/2014/137919
   Younus H, 2018, INT J HEALTH SCI-IJH, V12, P88
   Yu MA, 2010, J HYPERTENS, V28, P1234, DOI 10.1097/HJH.0b013e328337da1d
   Zhan YQ, 2019, CURR OPIN CARDIOL, V34, DOI 10.1097/HCO.0000000000000613
   Zhang XJ, 2018, CLIN RHEUMATOL, V37, P2539, DOI 10.1007/s10067-018-4132-0
NR 72
TC 22
Z9 24
U1 3
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JAN
PY 2021
VL 10
IS 1
AR 93
DI 10.3390/antiox10010093
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA PX1XW
UT WOS:000611156800001
PM 33440881
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kaneko, M
   Imaizumi, K
   Saito, A
   Kanemoto, S
   Asada, R
   Matsuhisa, K
   Ohtake, Y
AF Kaneko, Masayuki
   Imaizumi, Kazunori
   Saito, Atsushi
   Kanemoto, Soshi
   Asada, Rie
   Matsuhisa, Koji
   Ohtake, Yosuke
TI ER Stress and Disease: Toward Prevention and Treatment
SO BIOLOGICAL & PHARMACEUTICAL BULLETIN
LA English
DT Review
DE endoplasmic reticulum stress; unfolded protein response;
   neurodegenerative disease; diabetes; metabolic syndrome; cancer
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED-PROTEIN RESPONSE; BETA-CELL
   FAILURE; MESSENGER-RNA; TRANSLATIONAL CONTROL; TRANSCRIPTION FACTOR;
   GLUCOSE-HOMEOSTASIS; HEPATIC STEATOSIS; MAMMALIAN-CELLS; AMYLOID-BETA
AB Secretory and membrane proteins are synthesized in ribosomes, then mature in the endoplasmic reticulum (ER), but if ER function is impaired, immature defective proteins accumulate in the ER. This situation is. called ER stress: in response, a defensive mechanism called the unfolded protein response (UPR) is activated in cells to reduce the defective proteins. During the UPR, the ER transmembrane sensor molecules inositol-requiring enzyme 1 (IRE1), activating transcription factor 6 (ATF6), and RNA-dependent protein kinase (PKR)-like ER kinase (PERK) are activated, stress signals are transduced to the outside of the ER, and various cell responses, including gene induction, occur. In ER-associated degradation (ERAD), one type of UPR, defective proteins are eventually expelled from the ER and degraded in the cytoplasm through the ubiquitin proteasome system. Since ER stress has been reported to have relationships with neurodegenerative diseases, diabetes, metabolic syndromes, and cancer, it is the focus of increased attention from the perspectives of elucidating pathogenic mechanisms, and in the development of therapeutics.
C1 [Kaneko, Masayuki; Imaizumi, Kazunori; Kanemoto, Soshi; Asada, Rie; Ohtake, Yosuke] Hiroshima Univ, Inst Biomed & Hlth Sci, Dept Biochem, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348553, Japan.
   [Saito, Atsushi; Matsuhisa, Koji] Hiroshima Univ, Inst Biomed & Hlth Sci, Dept Stress Prot Proc, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348553, Japan.
C3 Hiroshima University; Hiroshima University
RP Kaneko, M (corresponding author), Hiroshima Univ, Inst Biomed & Hlth Sci, Dept Biochem, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348553, Japan.
EM mkaneko@hiroshima-u.ac.jp
RI 幸司, 松久/KGM-0809-2024; Kaneko, Masayuki/F-9302-2011; Saito,
   Atsushi/JQV-6748-2023
OI Kaneko, Masayuki/0000-0002-0477-0171; Matsuhisa,
   Koji/0000-0003-0707-9025; saito, atsushi/0000-0003-2425-3371
FU Grants-in-Aid for Scientific Research [17K15599] Funding Source: KAKEN
CR Acosta-Alvear D, 2007, MOL CELL, V27, P53, DOI 10.1016/j.molcel.2007.06.011
   Blais JD, 2006, MOL CELL BIOL, V26, P9517, DOI 10.1128/MCB.01145-06
   Boden G, 2008, DIABETES, V57, P2438, DOI 10.2337/db08-0604
   Bonifacino JS, 1998, ANNU REV CELL DEV BI, V14, P19, DOI 10.1146/annurev.cellbio.14.1.19
   Calfon M, 2002, NATURE, V415, P92, DOI 10.1038/415092a
   Delépine M, 2000, NAT GENET, V25, P406, DOI 10.1038/78085
   Egawa N, 2011, J BIOL CHEM, V286, P7947, DOI 10.1074/jbc.M110.156430
   Fernandez J, 2002, J BIOL CHEM, V277, P2050, DOI 10.1074/jbc.M109199200
   Fonseca SG, 2010, J CLIN INVEST, V120, P744, DOI 10.1172/JCI39678
   Harding HP, 2001, MOL CELL, V7, P1153, DOI 10.1016/S1097-2765(01)00264-7
   Harding HP, 1999, NATURE, V397, P271, DOI 10.1038/16729
   Harding HP, 2000, MOL CELL, V6, P1099, DOI 10.1016/S1097-2765(00)00108-8
   Harding HP, 2003, MOL CELL, V11, P619, DOI 10.1016/S1097-2765(03)00105-9
   Haze K, 1999, MOL BIOL CELL, V10, P3787, DOI 10.1091/mbc.10.11.3787
   Hetz C, 2003, EMBO J, V22, P5435, DOI 10.1093/emboj/cdg537
   Huber AL, 2013, MOL CELL, V49, P1049, DOI 10.1016/j.molcel.2013.01.009
   Imai Y, 2001, CELL, V105, P891, DOI 10.1016/S0092-8674(01)00407-X
   Kammoun HL, 2009, J CLIN INVEST, V119, P1201, DOI 10.1172/JCI37007
   Kaneko M, 2002, FEBS LETT, V532, P147, DOI 10.1016/S0014-5793(02)03660-8
   Kaneko M, 2010, J NEUROSCI, V30, P3924, DOI 10.1523/JNEUROSCI.2422-09.2010
   Katayama T, 1999, NAT CELL BIOL, V1, P479, DOI 10.1038/70265
   Kaufman RJ, 2004, TRENDS BIOCHEM SCI, V29, P152, DOI 10.1016/j.tibs.2004.01.004
   Kawasaki N, 2012, SCI REP-UK, V2, DOI 10.1038/srep00799
   Ladiges WC, 2005, DIABETES, V54, P1074, DOI 10.2337/diabetes.54.4.1074
   Lee AH, 2003, MOL CELL BIOL, V23, P7448, DOI 10.1128/MCB.23.21.7448-7459.2003
   Lee AH, 2011, P NATL ACAD SCI USA, V108, P8885, DOI 10.1073/pnas.1105564108
   Nadanaka S, 2007, MOL CELL BIOL, V27, P1027, DOI 10.1128/MCB.00408-06
   Nakagawa T, 2000, NATURE, V403, P98, DOI 10.1038/47513
   Nishitoh H, 2002, GENE DEV, V16, P1345, DOI 10.1101/gad.992302
   Nishitoh H, 2008, GENE DEV, V22, P1451, DOI 10.1101/gad.1640108
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Oyadomari S, 2002, J CLIN INVEST, V109, P525, DOI 10.1172/JCI200214550
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Romero-Ramirez L, 2004, CANCER RES, V64, P5943, DOI 10.1158/0008-5472.CAN-04-1606
   Ron D, 2007, NAT REV MOL CELL BIO, V8, P519, DOI 10.1038/nrm2199
   Roussel BD, 2013, LANCET NEUROL, V12, P105, DOI 10.1016/S1474-4422(12)70238-7
   Rutkowski DT, 2008, DEV CELL, V15, P829, DOI 10.1016/j.devcel.2008.10.015
   Saito A, 2014, ANAT SCI INT, V89, P11, DOI 10.1007/s12565-013-0214-x
   Scheuner D, 2001, MOL CELL, V7, P1165, DOI 10.1016/S1097-2765(01)00265-9
   Schewe DM, 2008, P NATL ACAD SCI USA, V105, P10519, DOI 10.1073/pnas.0800939105
   Siu F, 2002, J BIOL CHEM, V277, P24120, DOI 10.1074/jbc.M201959200
   Tirasophon W, 1998, GENE DEV, V12, P1812, DOI 10.1101/gad.12.12.1812
   Tsai B, 2002, NAT REV MOL CELL BIO, V3, P246, DOI 10.1038/nrm780
   Uehara T, 2006, NATURE, V441, P513, DOI 10.1038/nature04782
   Usui M, 2012, METABOLISM, V61, P1118, DOI 10.1016/j.metabol.2012.01.004
   Wang XZ, 1998, EMBO J, V17, P5708, DOI 10.1093/emboj/17.19.5708
   Ye J, 2000, MOL CELL, V6, P1355, DOI 10.1016/S1097-2765(00)00133-7
   Yoshida H, 2001, CELL, V107, P881, DOI 10.1016/S0092-8674(01)00611-0
   Yoshida H, 1998, J BIOL CHEM, V273, P33741, DOI 10.1074/jbc.273.50.33741
   Yoshida H, 2007, FEBS J, V274, P630, DOI 10.1111/j.1742-4658.2007.05639.x
NR 50
TC 100
Z9 107
U1 1
U2 19
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0918-6158
J9 BIOL PHARM BULL
JI Biol. Pharm. Bull.
PD SEP
PY 2017
VL 40
IS 9
BP 1337
EP 1343
DI 10.1248/bpb.b17-00342
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FF6WB
UT WOS:000409156600001
PM 28867719
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yi, MCL
   Cisneros, LC
   Cho, EJ
   Alexander, M
   Kimelman, FA
   Swentek, L
   Ferrey, A
   Tantisattamo, E
   Ichii, H
AF Yi, Michelle
   Cruz Cisneros, Leslie
   Cho, Eric J.
   Alexander, Michael
   Kimelman, Francesca A.
   Swentek, Lourdes
   Ferrey, Antoney
   Tantisattamo, Ekamol
   Ichii, Hirohito
TI Nrf2 Pathway and Oxidative Stress as a Common Target for Treatment of
   Diabetes and Its Comorbidities
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE diabetes; heart; kidney; liver; oxidative stress; Nrf2
ID STIMULATED LIPOPROTEIN RECEPTOR; IMPAIRED GLUCOSE-TOLERANCE; OXYGEN
   SPECIES PRODUCTION; FATTY LIVER-DISEASE; DIASTOLIC DYSFUNCTION;
   MITOCHONDRIAL SUPEROXIDE; MYOCARDIAL-INFARCTION; ALCOHOL-CONSUMPTION;
   THERAPEUTIC TARGET; METABOLIC SYNDROME
AB Diabetes is a chronic disease that induces many comorbidities, including cardiovascular disease, nephropathy, and liver damage. Many mechanisms have been suggested as to how diabetes leads to these comorbidities, of which increased oxidative stress in diabetic patients has been strongly implicated. Limited knowledge of antioxidative antidiabetic drugs and substances that can address diabetic comorbidities through the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway calls for detailed investigation. This review will describe how diabetes increases oxidative stress, the general impact of that oxidative stress, and how oxidative stress primarily contributes to diabetic comorbidities. It will also address how treatments for diabetes, especially focusing on their effects on the Nrf2 antioxidative pathway, have been shown to similarly affect the Nrf2 pathway of the heart, kidney, and liver systems. This review demonstrates that the Nrf2 pathway is a common pathogenic component of diabetes and its associated comorbidities, potentially identifying this pathway as a target to guide future treatments.
C1 [Yi, Michelle; Cruz Cisneros, Leslie; Cho, Eric J.; Alexander, Michael; Kimelman, Francesca A.; Swentek, Lourdes; Ichii, Hirohito] Univ Calif Irvine, Dept Surg, Irvine, CA 92697 USA.
   [Ferrey, Antoney; Tantisattamo, Ekamol] Univ Calif Irvine, Dept Med, Irvine, CA 92697 USA.
C3 University of California System; University of California Irvine;
   University of California System; University of California Irvine
RP Ichii, H (corresponding author), Univ Calif Irvine, Dept Surg, Irvine, CA 92697 USA.
EM myi10@hs.uci.edu; lcruzcis@hs.uci.edu; ejcho5@hs.uci.edu;
   michaela@hs.uci.edu; fkimelma@hs.uci.edu; lyrobles@hs.uci.edu;
   ferreya@hs.uci.edu; etantisa@hs.uci.edu; hichii@hs.uci.edu
RI Ichii, Hirohito/AAV-8256-2021
OI Yi, Michelle/0009-0007-7278-2661; Kimelman,
   Francesca/0009-0003-6639-1024; Tantisattamo, Ekamol/0000-0003-0883-6892
CR Abdelaziz AI, 2019, FOOD CHEM TOXICOL, V132, DOI 10.1016/j.fct.2019.110719
   Åberg F, 2018, HEPATOLOGY, V67, P2141, DOI 10.1002/hep.29631
   Adler AI, 2000, BMJ-BRIT MED J, V321, P412, DOI 10.1136/bmj.321.7258.412
   AIELLO LP, 1994, NEW ENGL J MED, V331, P1480, DOI 10.1056/NEJM199412013312203
   Andersen MJ, 2013, CIRCULATION, V127, P1200, DOI 10.1161/CIRCULATIONAHA.112.000056
   Araki E, 2010, J DIABETES INVEST, V1, P90, DOI 10.1111/j.2040-1124.2010.00013.x
   Arambasic J, 2013, EUR J NUTR, V52, P1461, DOI 10.1007/s00394-012-0452-z
   Arora MK, 2019, J DIET SUPPL, V16, P227, DOI 10.1080/19390211.2018.1449159
   Bae JC, 2010, AM J GASTROENTEROL, V105, P2389, DOI 10.1038/ajg.2010.275
   Baudoin L, 2015, FRONT ENDOCRINOL, V5, DOI [10.3389/fendo.2016.00235, 10.3389/fendo.2014.00235]
   Bellezza I, 2018, BBA-MOL CELL RES, V1865, P721, DOI 10.1016/j.bbamcr.2018.02.010
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Burlew BS, 2002, HERZ, V27, P92, DOI 10.1007/s00059-002-2354-y
   Candido R, 2003, CIRC RES, V92, P785, DOI 10.1161/01.RES.0000065620.39919.20
   Ceni E, 2014, WORLD J GASTROENTERO, V20, P17756, DOI 10.3748/wjg.v20.i47.17756
   Centers for Disease Control and Prevention, 2022, 2022 NAT DIAB STAT R
   Chang TT, 2021, J ETHNOPHARMACOL, V266, DOI 10.1016/j.jep.2020.113474
   Chang WG, 2015, BIOCHEM CELL BIOL, V93, P479, DOI 10.1139/bcb-2014-0107
   Chatterjee Paoulomi, 2012, Asian Pacific Journal of Tropical Biomedicine, V2, pS1754
   Chawla Aastha, 2016, Indian J Endocrinol Metab, V20, P546, DOI 10.4103/2230-8210.183480
   Chen PH, 2017, MOL CELL ONCOL, V4, DOI 10.1080/23723556.2017.1361501
   Chen PH, 2017, EMBO J, V36, P2233, DOI 10.15252/embj.201696113
   Cheng DY, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/162724
   Chian S, 2014, ASIAN PAC J CANCER P, V15, P2911, DOI 10.7314/APJCP.2014.15.6.2911
   Chiasson JL, 2003, JAMA-J AM MED ASSOC, V290, P486, DOI 10.1001/jama.290.4.486
   Chien CY, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9080679
   Chu SF, 2021, EUR J PHARMACOL, V913, DOI 10.1016/j.ejphar.2021.174628
   Chung SSM, 2003, J AM SOC NEPHROL, V14, pS233, DOI 10.1097/01.ASN.0000077408.15865.06
   Clark RJ, 2003, J BIOL CHEM, V278, P44230, DOI 10.1074/jbc.M303810200
   Cuadrado A, 2018, PHARMACOL REV, V70, P348, DOI 10.1124/pr.117.014753
   Cusi K, 2016, ANN INTERN MED, V165, P305, DOI 10.7326/M15-1774
   Dare A, 2021, BIOMED PHARMACOTHER, V141, DOI 10.1016/j.biopha.2021.111921
   David JA, 2017, J DIABETES RES, V2017, DOI 10.1155/2017/4826724
   de Boer IH, 2011, ARCH INTERN MED, V171, P412, DOI 10.1001/archinternmed.2011.16
   De Geest B, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11040784
   Deng CH, 2018, COMPUT INTEL NEUROSC, V2018, DOI 10.1155/2018/3094504
   Deyno S, 2019, DIABETES RES CLIN PR, V156, DOI 10.1016/j.diabres.2019.107815
   Dharmalingam Mala, 2018, Indian J Endocrinol Metab, V22, P421, DOI 10.4103/ijem.IJEM_585_17
   Dinic S, 2013, BRIT J NUTR, V110, P401, DOI 10.1017/S0007114512005429
   Dong YY, 2020, J SURG RES, V256, P345, DOI 10.1016/j.jss.2020.05.102
   Donnelly R, 2004, BRIT J OPHTHALMOL, V88, P145, DOI 10.1136/bjo.88.1.145
   Du JX, 2020, EXP THER MED, V20, P838, DOI 10.3892/etm.2020.8764
   Du YP, 2003, FREE RADICAL BIO MED, V35, P1491, DOI 10.1016/j.freeradbiomed.2003.08.018
   Ezhilarasan D, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/9233650
   Fathi R, 2020, LIFE SCI, V256, DOI 10.1016/j.lfs.2020.117958
   Felez-Nobrega M, 2023, INT J BEHAV NUTR PHY, V20, DOI 10.1186/s12966-022-01404-y
   Filippatos G, 2022, CIRCULATION, V146, P676, DOI 10.1161/CIRCULATIONAHA.122.059785
   Fisher M, 1999, BEST PRACT RES CL EN, V13, P331, DOI 10.1053/beem.1999.0024
   Ford RJ, 2015, BIOCHEM J, V468, P125, DOI 10.1042/BJ20150125
   Forouzandeh F, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.114.001202
   Freigang S, 2011, EUR J IMMUNOL, V41, P2040, DOI 10.1002/eji.201041316
   Gao AM, 2013, CARCINOGENESIS, V34, P1806, DOI 10.1093/carcin/bgt108
   Gao Y, 2001, J BIOL CHEM, V276, P9838, DOI 10.1074/jbc.M010420200
   Neto JCGL, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000018553
   Gaspari T, 2013, DIABETES VASC DIS RE, V10, P353, DOI 10.1177/1479164113481817
   Giacco F, 2010, CIRC RES, V107, P1058, DOI 10.1161/CIRCRESAHA.110.223545
   Glass CK, 2001, CELL, V104, P503, DOI 10.1016/S0092-8674(01)00238-0
   Golbidi S, 2012, EXP DIABETES RES, DOI 10.1155/2012/941868
   GRANT DM, 1991, J INHERIT METAB DIS, V14, P421, DOI 10.1007/BF01797915
   Gu Y, 2018, EUR REV MED PHARMACO, V22, P8973, DOI 10.26355/eurrev_201812_16668
   Guo M, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.830532
   Gupta N, 2013, OPEN OPHTHALMOL J, V7, P4, DOI 10.2174/1874364101307010004
   Halimi S, 2014, DIABETES METAB, V40, pS28, DOI 10.1016/S1262-3636(14)72693-X
   HALTIWANGER RS, 1992, J BIOL CHEM, V267, P9005
   Hammoudi N, 2017, CARDIOVASC DRUG THER, V31, P233, DOI 10.1007/s10557-017-6734-1
   Hazlehurst JM, 2016, METABOLISM, V65, P1096, DOI 10.1016/j.metabol.2016.01.001
   Hosseini-Fard SR, 2022, LIFE SCI, V300, DOI 10.1016/j.lfs.2022.120576
   Hovind P, 2004, BMJ-BRIT MED J, V328, P1105, DOI 10.1136/bmj.38070.450891.FE
   Huang SS, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/2586305
   Huang TC, 2011, J AGR FOOD CHEM, V59, P5164, DOI 10.1021/jf200579h
   Hüttl M, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222111513
   Ichiki T, 2012, REGUL PEPTIDES, V177, P35, DOI 10.1016/j.regpep.2012.04.005
   Inoguchi T, 2000, DIABETES, V49, P1939, DOI 10.2337/diabetes.49.11.1939
   Jian Z, 2011, J INVEST DERMATOL, V131, P1420, DOI 10.1038/jid.2011.56
   Jin JL, 2020, CARDIOVASC DIABETOL, V19, DOI 10.1186/s12933-020-01015-6
   Jin S, 2011, FOOD CHEM TOXICOL, V49, P1521, DOI 10.1016/j.fct.2011.03.043
   Jun JY, 2011, AM J PHYSIOL-ENDOC M, V301, pE145, DOI 10.1152/ajpendo.00034.2011
   Kamboj P, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/4632491
   Kang H, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-90
   Kawanami D, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21124239
   Kawase Y, 2008, NAT CLIN PRACT CARD, V5, P554, DOI 10.1038/ncpcardio1301
   Khalaf MM, 2022, CURR MOL PHARMACOL, V15, P213, DOI 10.2174/1874467214666210525153111
   Kiechl S, 1998, STROKE, V29, P900, DOI 10.1161/01.STR.29.5.900
   Kong LM, 2021, CELL DEATH DIS, V12, DOI 10.1038/s41419-021-04227-0
   Kotronen A, 2008, DIABETES CARE, V31, P165, DOI 10.2337/dc07-1463
   Kumar A, 2011, MOL PHARMACOL, V80, P446, DOI 10.1124/mol.111.071126
   LEE AYW, 1995, P NATL ACAD SCI USA, V92, P2780, DOI 10.1073/pnas.92.7.2780
   Lee AYW, 1999, FASEB J, V13, P23, DOI 10.1096/fasebj.13.1.23
   Li S, 2015, INT J MOL SCI, V16, P26087, DOI 10.3390/ijms161125942
   Lim J.-H., Sodium-Glucose Cotransporter 2 Inhibitors in Kidney Transplant Recipients
   Ma JQ, 2015, CLIN RES HEPATOL GAS, V39, P188, DOI 10.1016/j.clinre.2014.09.007
   Meakin PJ, 2014, MOL CELL BIOL, V34, P3305, DOI [10.1128/MCB.00677-14, 10.1128/MCB.00677-1]
   Milani L, 2019, ANN HEPATOL, V18, P918, DOI 10.1016/j.aohep.2019.04.011
   Miller M, 2018, J AM COLL CARDIOL, V72, P170, DOI 10.1016/j.jacc.2018.03.541
   Min-DeBartolo J, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0226854
   MOGENSEN CE, 1984, NEW ENGL J MED, V311, P89, DOI 10.1056/NEJM198407123110204
   Motohashi H, 2004, P NATL ACAD SCI USA, V101, P6379, DOI 10.1073/pnas.0305902101
   Movahed A, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/851267
   Mueller T, 2021, FRONT AGING-LAUSANNE, V1, DOI 10.3389/fragi.2020.620382
   Nagashima M, 2011, DIABETOLOGIA, V54, P2649, DOI 10.1007/s00125-011-2241-2
   Narvekar P, 2009, DIABETES, V58, P1040, DOI 10.2337/db08-1184
   Nayak IMN, 2017, J CLIN DIAGN RES, V11, DOI 10.7860/JCDR/2017/23910.9864
   Nishikawa T, 2000, NATURE, V404, P787, DOI 10.1038/35008121
   Nowotny K, 2015, BIOMOLECULES, V5, P194, DOI 10.3390/biom5010194
   Okamura T, 2020, BMJ OPEN DIAB RES CA, V8, DOI 10.1136/bmjdrc-2020-001629
   Orasanu G, 2009, J AM COLL CARDIOL, V53, pS35, DOI 10.1016/j.jacc.2008.09.055
   Osonoi Y, 2018, AUTOPHAGY, V14, P1991, DOI 10.1080/15548627.2018.1501132
   Pabel S, 2018, EUR J HEART FAIL, V20, P1690, DOI 10.1002/ejhf.1328
   Pais R, 2013, J HEPATOL, V59, P550, DOI 10.1016/j.jhep.2013.04.027
   Petrie JR, 2017, LANCET DIABETES ENDO, V5, P597, DOI 10.1016/S2213-8587(17)30194-8
   Picatoste B, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0078330
   Qi M, 2022, ENVIRON POLLUT, V293, DOI 10.1016/j.envpol.2021.118572
   Qi Y, 2020, J ATHEROSCLER THROMB, V27, P695, DOI 10.5551/jat.49841
   Qiu P, 2017, TOXICOL LETT, V274, P31, DOI 10.1016/j.toxlet.2017.04.009
   Rakipovski G, 2018, JACC-BASIC TRANSL SC, V3, P844, DOI 10.1016/j.jacbts.2018.09.004
   Robledinos-Antón N, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/9372182
   Ruotsalainen AK, 2013, CARDIOVASC RES, V98, P107, DOI 10.1093/cvr/cvt008
   Sena CM, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12010082
   Serina JJC, 2022, CRIT REV FOOD SCI, V62, P8355, DOI 10.1080/10408398.2021.1927977
   Sheetz MJ, 2002, JAMA-J AM MED ASSOC, V288, P2579, DOI 10.1001/jama.288.20.2579
   Shi Y, 2013, ACTA PHARMACOL SIN, V34, P1140, DOI 10.1038/aps.2013.59
   Shi ZM, 2021, INT J CLIN EXP PATHO, V14, P972
   Albert-Garay JS, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-05284-x
   Stefanson AL, 2014, NUTRIENTS, V6, P3777, DOI 10.3390/nu6093777
   Sun LP, 2023, EXP THER MED, V25, DOI 10.3892/etm.2023.11948
   Svegliati-Baroni G, 2011, LIVER INT, V31, P1285, DOI 10.1111/j.1478-3231.2011.02462.x
   Tang XW, 2011, FREE RADICAL BIO MED, V50, P1599, DOI 10.1016/j.freeradbiomed.2011.03.008
   Tashiro Y, 2014, PEPTIDES, V54, P19, DOI 10.1016/j.peptides.2013.12.015
   TESFAMARIAM B, 1994, FREE RADICAL BIO MED, V16, P383, DOI 10.1016/0891-5849(94)90040-X
   Tribble DL, 2001, AM J MED, V110, P103, DOI 10.1016/S0002-9343(00)00700-2
   Tsang CK, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4446
   Tu WJ, 2019, AGING DIS, V10, P637, DOI 10.14336/AD.2018.0513
   Unnikrishnan R, 2007, DIABETES CARE, V30, P2019, DOI 10.2337/dc06-2554
   Vallon V, 2014, AM J PHYSIOL-RENAL, V306, pF194, DOI 10.1152/ajprenal.00520.2013
   Vikramadithyan RK, 2005, J CLIN INVEST, V115, P2434, DOI 10.1172/JCI24819
   von Bibra H, 2010, DIABETOLOGIA, V53, P1033, DOI 10.1007/s00125-010-1682-3
   Wang JW, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/1122494
   Wang J, 2018, DRUG DES DEV THER, V12, P721, DOI 10.2147/DDDT.S160020
   Wang ML, 2017, CELL PHYSIOL BIOCHEM, V43, P1731, DOI 10.1159/000484060
   Wautier JL, 2004, CIRC RES, V95, P233, DOI 10.1161/01.RES.0000137876.28454.64
   Wondrak GT, 2010, MOLECULES, V15, P3338, DOI 10.3390/molecules15053338
   Xu XF, 2014, BIOCHEM PHARMACOL, V92, P220, DOI 10.1016/j.bcp.2014.09.008
   Yan Y, 2019, BIOFACTORS, V45, P598, DOI 10.1002/biof.1521
   Yang M, 2022, BIOENGINEERED, V13, P13162, DOI 10.1080/21655979.2022.2074109
   Yao MY, 2014, J AM SOC NEPHROL, V25, P1171, DOI 10.1681/ASN.2013040433
   Yen FT, 2008, J BIOL CHEM, V283, P25650, DOI 10.1074/jbc.M801027200
   You GH, 2020, DRUG DES DEV THER, V14, P457, DOI 10.2147/DDDT.S233932
   Yu C, 2018, CANCER MED-US, V7, P471, DOI 10.1002/cam4.1287
   Zhang J, 2023, INT J BIOL SCI, V19, P3029, DOI 10.7150/ijbs.82401
NR 149
TC 18
Z9 20
U1 3
U2 22
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2024
VL 25
IS 2
AR 821
DI 10.3390/ijms25020821
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GF7O5
UT WOS:001151318200001
PM 38255895
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU D'Alonzo, KT
   Munet-Vilaro, F
   Carmody, DP
   Guarnaccia, PJ
   Linn, AM
   Garsman, L
AF D'Alonzo, Karen Therese
   Munet-Vilaro, Frances
   Carmody, Dennis P.
   Guarnaccia, Peter J.
   Linn, Anne Marie
   Garsman, Lisa
TI Acculturation stress and allostatic load among Mexican immigrant women
SO REVISTA LATINO-AMERICANA DE ENFERMAGEM
LA English
DT Review
DE Allostasis; Acculturation; Obesity; Immigrants; Metabolic Syndrome;
   Case-Control Study
ID HEALTH
AB Objectives: this case-control study compared levels of stress and allostatic load (AL) among Mexican women in the US (n = 19) and Mexico (n = 40). Method: measures of stress included the Perceived Stress Scale (PSS) and the Hispanic Women's Social Stressor Scale (HWSSS). A composite measure of 8 indicators of AL (systolic and diastolic blood pressure, body mass index (BMI), waist-to-hip ratio, total cholesterol, glycated hemoglobin (hemoglobin A1C), triglycerides and C-reactive protein) was calculated. Results: there were no significant group differences in AL between Mexican and Mexican immigrant women (t = 1.55, p = .126). A principal component factor analysis was conducted on the 8 AL indicators; a 2-factor solution explained 57% of the variance. Group differences in the two AL factors were analyzed using MANOVA. BMI and waist-to-hip ratios were lower, but blood pressure and triglycerides were higher in the US group and were mediated by time in the US. Greater acculturation stress was significantly related to increased waist-to-hip ratio (r = .57, p = .02). Final remarks: findings suggest some measures of AL increased with time in the US, and acculturation stress may be a significant factor.
C1 [D'Alonzo, Karen Therese; Carmody, Dennis P.; Linn, Anne Marie] Rutgers State Univ, Sch Nursing, Newark, NJ 07102 USA.
   [Munet-Vilaro, Frances] Calif State Univ Monterey Bay, Dept Nursing, Seaside, CA USA.
   [Guarnaccia, Peter J.] Rutgers State Univ, Dept Human Ecol, New Brunswick, NJ USA.
   [Garsman, Lisa] St Peters Univ, Sch Nursing, Jersey City, NJ USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Newark; California State University System; California State
   University Monterey Bay; Rutgers University System; Rutgers University
   New Brunswick
RP D'Alonzo, KT (corresponding author), Rutgers State Univ, Sch Nursing, Newark, NJ 07102 USA.
EM kdalonzo@sn.rutgers.edu
RI D'Alonzo, Karen/GSM-6563-2022; Carmody, Dennis/AAS-7734-2020
OI Garsman, Lisa/0000-0001-6598-255X; Linn, Anne/0000-0001-9720-2378;
   Carmody, Dennis/0000-0002-1288-104X; Munet-Vilaro,
   Frances/0000-0002-3049-238X
FU International Collaborative Research Grant from The Centers for Global
   Advancement and International Affairs (GAIA Centers) at Rutgers, the
   State University of New Jersey, USA
FX Supported by International Collaborative Research Grant from The Centers
   for Global Advancement and International Affairs (GAIA Centers) at
   Rutgers, the State University of New Jersey, USA.
CR [Anonymous], 1992, AM J EPIDEMIOL, V135, P1029
   [Anonymous], STAT METHODS MED RES
   Berry JW, 1997, APPL PSYCHOL-INT REV, V46, P5, DOI 10.1111/j.1464-0597.1997.tb01087.x
   Caplan Susan, 2007, Policy Polit Nurs Pract, V8, P93, DOI 10.1177/1527154407301751
   Cervantes R., 1991, Psychological Assessment, V3, P438, DOI [DOI 10.1037/1040-3590.3.3.438, 10.1037/1040-3590.3.3.438]
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   D'Alonzo KT, 2018, J TRANSCULT NURS, V29, P335, DOI 10.1177/1043659617723073
   de la Garza R., 2010, Migration, development and children left-behind: A multidimensional perspective
   Fernandez-Huerta J., 1959, Consigna, V214, P29
   Finch Brian Karl, 2003, J Immigr Health, V5, P109, DOI 10.1023/A:1023987717921
   Flores Antonio., 2015, Facts on U.S. Latinos
   Gonzalez-Barrera Ana., 2015, More Mexicans Leaving than Coming to U.S
   Grimes DA, 2005, LANCET, V365, P1429, DOI 10.1016/S0140-6736(05)66379-9
   Hayes A.F., 2013, Introduction to mediation, moderation, and conditional process analysis: A regression-based approach. Introduction to mediation, moderation, P507, DOI DOI 10.1111/JEDM.12050
   Hovey J D, 2000, Cultur Divers Ethnic Minor Psychol, V6, P134, DOI 10.1037/1099-9809.6.2.134
   Institute for Mexicans Abroad, 2015, DO YOU KNOW MAN MEX
   Kaestner R, 2009, SOC SCI QUART, V90, P1089, DOI 10.1111/j.1540-6237.2009.00648.x
   MARKIDES KS, 1986, PUBLIC HEALTH REP, V101, P253
   McCaffery JM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047246
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   Mei J, 2014, WIL SER PHARM SCI BI, P21
   Nunnally Jr JC, 1978, PSYCHOMETRIC THEORY, V2nd
   Passel J.S., 2014, As growth stalls, unauthorized immigrant population becomes more settled
   Remor E, 2006, SPAN J PSYCHOL, V9, P86, DOI 10.1017/S1138741600006004
   González-Ramírez MT, 2013, SPAN J PSYCHOL, V16, DOI 10.1017/sjp.2013.35
   2004, AM J PUBLIC HLTH, V94, P1807
   2001, MULTIVARIATE BEHAV R, V36, P611
   2012, SOC SCI MED, V74, P135, DOI DOI 10.1016/J.SOCSCIMED.2011.10.020
   1984, PSYCHOMETRIKA, V49, P155, DOI DOI 10.1007/BF02294170
   2013, HISPANIC J BEHAV SCI, V35, P486, DOI DOI 10.1177/0739986313499004
   1999, AM J EPIDEMIOL, V149, P195
   NEUROPSYCHOPHARMACOL, V22, P108, DOI DOI 10.1016/S0893-133X(99)00129-3
   2014, AM J HUM BIOL, V26, P1, DOI DOI 10.1002/AJHB.22463
   1994, NUTR REV, V52, P285, DOI DOI 10.1111/J.1753-4887.1994.TB01460.X
   2012, BIOL RES NURS, V14, P364, DOI DOI 10.1177/1099800412457017
   2010, AM J PUBLIC HEALTH, V100, P940, DOI DOI 10.2105/AJPH.2007.129312
   2012, BIOL RES NURS, V14, P311, DOI DOI 10.1177/1099800412455688
   2002, BEHAV GENET, V32, P153
   2011, ANN BEHAV MED, V41, P21, DOI DOI 10.1007/S10903-014-0066-Z
   2001, P NATL ACAD SCI USA, V98, P4770, DOI DOI 10.1073/PNAS.081072698
   2003, ARCH INTER MED, V163, P427
   2010, AM PSYCHOL, V65, P237, DOI DOI 10.1037/A0019330
   2008, HISPANIC J BEHAV SCI, V30, P200, DOI DOI 10.1177/0739986308316178
   2014, AM J HYPERTENS, V27, P793, DOI DOI 10.1093/AJH/HPU003
   2008, RES NURS HLTH, V31, P180, DOI DOI 10.1002/NUR.20247
   2008, SOC SCI MED, V66, P525, DOI DOI 10.1016/J.SOCSCIMED.2007.09.006
   2015, J IMMIGR MINOR HEALT, V17, P1518, DOI DOI 10.1007/S10903-014-0066-Z
NR 47
TC 11
Z9 14
U1 0
U2 8
PU UNIV SAO PAULO, ESCOLA DE ENFERMAGEM DE RIBEIRAO PRETO
PI RIBEIRAO PRETO
PA AV BANDEIRANTES, 3900, RIBEIRAO PRETO, SP 14040-902  A, BRAZIL
SN 1518-8345
J9 REV LAT-AM ENFERM
JI Rev. Latino-Am. Enfermagem
PY 2019
VL 27
AR e3135
DI 10.1590/1518-8345.2578.3135
PG 11
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA HY7IQ
UT WOS:000468308600001
PM 31038629
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Raygan, F
   Rezavandi, Z
   Tehrani, SD
   Farrokhian, A
   Asemi, Z
AF Raygan, Fariba
   Rezavandi, Zohreh
   Tehrani, Sahar Dadkhah
   Farrokhian, Alireza
   Asemi, Zatollah
TI The effects of coenzyme Q10 administration on glucose homeostasis
   parameters, lipid profiles, biomarkers of inflammation and oxidative
   stress in patients with metabolic syndrome (Publication with Expression
   of Concern)
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article; Publication with Expression of Concern
DE Coenzyme Q10; Supplementation; Metabolic syndrome; Type 2 diabetes
   mellitus; Coronary heart disease
ID Q(10) SUPPLEMENTATION; INSULIN-RESISTANCE; GLYCEMIC CONTROL; PLASMA;
   DISEASE; ARTERY; INTERLEUKIN-6; DYSFUNCTION; INDEXES
AB Limited data are available indicating the effects of coenzyme Q10 (CoQ10) supplementation on metabolic status of patients with metabolic syndrome (MetS).
   The present study was conducted to determine the effects of CoQ10 administration on glucose homeostasis parameters, lipid profiles, biomarkers of inflammation and oxidative stress among patients with MetS.
   This randomized, double-blind, placebo-controlled trial was performed among 60 overweight or obese and type 2 diabetes mellitus patients with coronary heart disease aged 40-85 years old. Participants were randomly allocated into two groups. Group A (n = 30) received 100 mg CoQ10 supplements and group B (n = 30) received placebo for 8 weeks. Fasting blood samples were taken at the beginning of the study and after 8-week intervention to quantify glucose homeostasis parameters, lipid profiles and biomarkers of inflammation and oxidative stress.
   Compared with the placebo, CoQ10 supplementation resulted in a significant reduction in serum insulin levels (-2.1 +/- A 7.1 vs. +4.1 +/- A 7.8 A mu IU/mL, P = 0.002) and homeostasis model of assessment-insulin resistance (-0.7 +/- A 2.1 vs. +1.0 +/- A 2.0, P = 0.002) and homeostatic model assessment-beta cell function (-5.9 +/- A 22.2 vs. +15.9 +/- A 34.0, P = 0.005). In addition, patients who received CoQ10 supplements had a significant increase in plasma total antioxidant capacity (TAC) concentrations (+26.0 +/- A 105.0 vs. -162.2 +/- A 361.8 mmol/L, P = 0.008) compared with the placebo group. However, after adjustment for the baseline levels, age and baseline BMI, the effect on TAC levels (P = 0.08) disappeared. Additionally, compared with the placebo group, a significant positive trends in plasma glutathione (P = 0.06) and a significant reduction in malondialdehyde (P = 0.08) were seen among patients who received CoQ10 supplement. We did not observe any significant changes in fasting plasma glucose, lipid concentrations and inflammatory markers.
   Overall, daily intake of 100 mg CoQ10 supplements among patients with MetS for 8 weeks had beneficial effects on serum insulin levels, HOMA-IR, HOMA-B and plasma TAC concentrations.
   www.irct.ir http://www.irct.ir" TargetType="URL" IRCT201502245623N35.
C1 [Raygan, Fariba; Rezavandi, Zohreh; Farrokhian, Alireza] Kashan Univ Med Sci, Sch Med, Dept Cardiol, Kashan, Iran.
   [Tehrani, Sahar Dadkhah; Asemi, Zatollah] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
RP Asemi, Z (corresponding author), Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
EM asemi_r@yahoo.com
RI Raygan, Fariba/W-3349-2017; asemi, zatollah/J-2677-2018; Asemi,
   Zatollah/G-7393-2017; Farrokhian, Alireza/G-8864-2017
OI Asemi, Zatollah/0000-0001-5265-4792; Raygan, Fariba/0000-0003-3789-5584;
   Dadkhah Tehrani, Sahar/0009-0002-3264-8840; Farrokhian,
   Alireza/0000-0002-7814-5539
FU KUMS, Iran
FX The current study was founded by a grant from the Vice-chancellor for
   Research, KUMS, Iran. The authors would like to thank the staff of
   Naghavi Clinic (Kashan, Iran) for their assistance in this project.
CR Amin MM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0089169
   [Anonymous], CLIN BIOCH
   Arroyo A, 2000, ANTIOXID REDOX SIGN, V2, P251, DOI 10.1089/ars.2000.2.2-251
   Asemi Z, 2014, CLIN NUTR, V33, P198, DOI 10.1016/j.clnu.2013.05.015
   Benzie IFF, 1996, ANAL BIOCHEM, V239, P70, DOI 10.1006/abio.1996.0292
   BEUTLER E, 1985, J LAB CLIN MED, V105, P581
   Brownlee M, 2005, DIABETES, V54, P1615, DOI 10.2337/diabetes.54.6.1615
   Carmona MC, 2009, INT J OBESITY, V33, P204, DOI 10.1038/ijo.2008.265
   Chokrungvaranon N, 2011, POSTGRAD MED, V123, P114, DOI 10.3810/pgm.2011.11.2501
   Crane FL, 2001, J AM COLL NUTR, V20, P591, DOI 10.1080/07315724.2001.10719063
   Díaz-Castro J, 2012, EUR J NUTR, V51, P791, DOI 10.1007/s00394-011-0257-5
   Farhangi MA, 2014, ARCH MED RES, V45, P589, DOI 10.1016/j.arcmed.2014.11.001
   Fiorentino TV, 2013, CURR PHARM DESIGN, V19, P5695, DOI 10.2174/1381612811319320005
   Garrido-Maraver J, 2014, MOL SYNDROMOL, V5, P187, DOI 10.1159/000360101
   Gökbel H, 2010, J MED FOOD, V13, P216, DOI 10.1089/jmf.2008.0310
   Hodgson JM, 2002, EUR J CLIN NUTR, V56, P1137, DOI 10.1038/sj.ejcn.1601464
   JANERO DR, 1990, FREE RADICAL BIO MED, V9, P515, DOI 10.1016/0891-5849(90)90131-2
   Kolahdouz Mohammadi R, 2013, Minerva Gastroenterol Dietol, V59, P231
   Lee BJ, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-142
   Lee BJ, 2012, NUTRITION, V28, P767, DOI 10.1016/j.nut.2011.11.008
   Lee BJ, 2012, NUTRITION, V28, P250, DOI 10.1016/j.nut.2011.06.004
   Lee YJ, 2011, J MED FOOD, V14, P386, DOI 10.1089/jmf.2010.1202
   Mancini A, 2007, ARCH ANDROLOGY, V53, P37, DOI 10.1080/01485010600840756
   Mehmetoglu I, 2011, J CLIN BIOCHEM NUTR, V49, P159, DOI 10.3164/jcbn.11-08
   Miles MV, 2004, CLIN CHIM ACTA, V344, P173, DOI 10.1016/j.cccn.2004.02.016
   Miyake Y, 1999, ARZNEIMITTELFORSCH, V49, P324
   Park E, 2010, NUTR RES PRACT, V4, P311, DOI 10.4162/nrp.2010.4.4.311
   Pisprasert V, 2013, DIABETES CARE, V36, P845, DOI 10.2337/dc12-0840
   Schmelzer C, 2008, BIOFACTORS, V32, P179, DOI 10.1002/biof.5520320121
   Sivitz WI, 2010, ANTIOXID REDOX SIGN, V12, P537, DOI 10.1089/ars.2009.2531
   Suksomboon N, 2015, J CLIN PHARM THER, V40, P413, DOI 10.1111/jcpt.12280
   Watts GF, 2002, DIABETOLOGIA, V45, P420, DOI 10.1007/s00125-001-0760-y
   Welles CC, 2014, AM J EPIDEMIOL, V179, P1279, DOI 10.1093/aje/kwu059
NR 33
TC 69
Z9 70
U1 0
U2 12
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD DEC
PY 2016
VL 55
IS 8
BP 2357
EP 2364
DI 10.1007/s00394-015-1042-7
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ED6NY
UT WOS:000388973500003
PM 26385228
DA 2025-06-11
ER

PT J
AU Dimova, LG
   Battista, S
   Plösch, T
   Kampen, RA
   Liu, F
   Verkaik-Schakel, RN
   Pratico, D
   Verkade, HJ
   Tietge, UJF
AF Dimova, Lidiya G.
   Battista, Simone
   Plosch, Torsten
   Kampen, Rosalie A.
   Liu, Fan
   Verkaik-Schakel, Rikst Nynke
   Pratico, Domenico
   Verkade, Henkjan J.
   Tietge, Uwe J. F.
TI Gestational oxidative stress protects against adult obesity and insulin
   resistance
SO REDOX BIOLOGY
LA English
DT Article
DE Fetal oxidative stress; Mitohormesis; Metabolic programming; Adiposity;
   Epigenetics; Methylation
ID CHOLESTEROL; MOUSE; GENE; EXPRESSION; ORIGINS; GLUCOSE; FETAL; MICE;
   CELL
AB Pregnancy complications such as preeclampsia cause increased fetal oxidative stress and fetal growth restriction, and associate with a higher incidence of adult metabolic syndrome. However, the pathophysiological contribution of oxidative stress per se is experimentally difficult to discern and has not been investigated. This study determined, if increased intrauterine oxidative stress (IUOx) affects adiposity, glucose and cholesterol metabolism in adult Ldlr-/-xSod2+/+ offspring from crossing male Ldlr-/-xSod2+/+ mice with Ldlr-/-xSod2+/- dams (IUOx) or Ldlr-/-xSod2+/- males with Ldlr-/-xSod2+/+ dams (control). At 12 weeks of age mice received Western diet for an additional 12 weeks. Adult male IUOx offspring displayed lower body weight and reduced adiposity associated with improved glucose tolerance compared to controls. Reduced weight gain in IUOx was conceivably due to increased energy dissipation in white adipose tissue conveyed by higher expression of Ucp1 and an accompanying decrease in DNA methylation in the Ucp1 enhancer region. Female offspring did not show comparable phenotypes. These results demonstrate that fetal oxidative stress protects against the obesogenic effects of Western diet in adulthood by programming energy dissipation in white adipose tissue at the level of Ucp1.
C1 [Dimova, Lidiya G.; Battista, Simone; Kampen, Rosalie A.; Liu, Fan; Verkade, Henkjan J.; Tietge, Uwe J. F.] Univ Groningen, Univ Med Ctr Groningen, Dept Pediat, Hanzepl 1, Groningen, Netherlands.
   [Plosch, Torsten; Verkaik-Schakel, Rikst Nynke] Univ Groningen, Univ Med Ctr Groningen, Dept Obstet & Gynecol, Hanzepl 1, Groningen, Netherlands.
   [Pratico, Domenico] Temple Univ, Lewis Katz Sch Med, Alzheimers Ctr Temple, 3500 N Broad St, Philadelphia, PA 19122 USA.
   [Liu, Fan; Tietge, Uwe J. F.] Karolinska Inst, Dept Lab Med, Div Clin Chem, Alfred Nobels Alle 8, Stockholm, Sweden.
   [Tietge, Uwe J. F.] Karolinska Univ Hosp, Karolinska Univ Lab, Clin Chem, Stockholm, Sweden.
C3 University of Groningen; University of Groningen; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Temple University;
   Karolinska Institutet; Karolinska Institutet; Karolinska University
   Hospital
RP Tietge, UJF (corresponding author), Karolinska Inst, Dept Lab Med LABMED, Div Clin Chem, H5,Alfred Nobels Alle 8, S-14183 Stockholm, Sweden.
EM u_tietge@yahoo.com
RI Liu, Fan/B-8833-2013; Plösch, Torsten/X-6808-2019; Pratico,
   Domenico/ABA-9590-2020; Dimova, Lidiya/E-3224-2017
OI Verkade, Henkjan J/0000-0002-7034-2861; Liu, Fan/0000-0001-9647-6705;
   Dimova, Lidiya/0000-0002-7387-4564
FU Dutch Technology Foundation STW [11675]; Danone Nutricia Research
FX This work was supported by the Dutch Technology Foundation STW
   (www.stw.nl, grant: 11675) and was partly funded by Danone Nutricia
   Research. STW is now part of the Netherlands Organisation for Scientific
   Research.
CR BARKER DJP, 1995, EUR J CLIN INVEST, V25, P457, DOI 10.1111/j.1365-2362.1995.tb01730.x
   Brondani LD, 2012, ARQ BRAS ENDOCRINOL, V56, P215
   Dikkers A, 2013, HEPATOLOGY, V58, P293, DOI 10.1002/hep.26316
   Dimova LG, 2017, GASTROENTEROLOGY, V153, P382, DOI 10.1053/j.gastro.2017.04.019
   Dunwoodie SL, 2009, DEV CELL, V17, P755, DOI 10.1016/j.devcel.2009.11.008
   Echtay KS, 2002, NATURE, V415, P96, DOI 10.1038/415096a
   Harrison D, 2003, AM J CARDIOL, V91, p7A
   ISHIBASHI S, 1993, J CLIN INVEST, V92, P883, DOI 10.1172/JCI116663
   Jones JR, 2005, P NATL ACAD SCI USA, V102, P6207, DOI 10.1073/pnas.0306743102
   Kokoszka JE, 2001, P NATL ACAD SCI USA, V98, P2278, DOI 10.1073/pnas.051627098
   Lebovitz RM, 1996, P NATL ACAD SCI USA, V93, P9782, DOI 10.1073/pnas.93.18.9782
   Mao J, 2010, P NATL ACAD SCI USA, V107, P5557, DOI 10.1073/pnas.1000440107
   Morrison JL, 2010, PEDIATR NEPHROL, V25, P669, DOI 10.1007/s00467-009-1407-3
   MUSKIET FAJ, 1983, J CHROMATOGR, V278, P231, DOI 10.1016/S0378-4347(00)84782-9
   Pomara N, 2012, AM J PSYCHIAT, V169, P523, DOI 10.1176/appi.ajp.2011.11081153
   Puigserver P, 1998, CELL, V92, P829, DOI 10.1016/S0092-8674(00)81410-5
   Ristow M, 2014, NAT MED, V20, P709, DOI 10.1038/nm.3624
   Ristow M, 2009, P NATL ACAD SCI USA, V106, P8665, DOI 10.1073/pnas.0903485106
   Shore A, 2010, DIABETOLOGIA, V53, P1164, DOI 10.1007/s00125-010-1701-4
   Song H, 2019, BIOL REPROD, V100, P208, DOI 10.1093/biolre/ioy167
   Tchirikov M, 2018, PHYSIOL REP, V6, DOI 10.14814/phy2.13589
   Thompson LP, 2012, J PREGNANCY, V2012, DOI 10.1155/2012/582748
   van Dijk TH, 2013, LAB ANIM-UK, V47, P79, DOI 10.1177/0023677212473714
   Wang XL, 2004, DIABETES, V53, P129, DOI 10.2337/diabetes.53.1.129
   Winzell MS, 2004, DIABETES, V53, pS215, DOI 10.2337/diabetes.53.suppl_3.S215
   Wu J, 2012, CELL, V150, P366, DOI 10.1016/j.cell.2012.05.016
   Yu S, 2016, AGING-US, V8, P2538, DOI 10.18632/aging.101084
NR 27
TC 4
Z9 5
U1 0
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD JAN
PY 2020
VL 28
AR 101329
DI 10.1016/j.redox.2019.101329
PG 6
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA JU2FG
UT WOS:000501490700033
PM 31550664
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rafiei, H
   Omidian, K
   Bandy, B
AF Rafiei, Hossein
   Omidian, Kosar
   Bandy, Brian
TI Protection by different classes of dietary polyphenols against palmitic
   acid-induced steatosis, nitro-oxidative stress and endoplasmic reticulum
   stress in HepG2 hepatocytes
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Non-alcoholic fatty liver disease; Functional food polyphenols;
   Endoplasmic reticulum stress; Oxidative stress; Mitochondrial
   dysfunction
ID FATTY LIVER-DISEASE; NF-KAPPA-B; MITOCHONDRIAL DYSFUNCTION; GREEN TEA;
   CHEMICAL CHAPERONES; INSULIN-RESISTANCE; GLUCOSE-HOMEOSTASIS;
   LIPID-ACCUMULATION; METABOLIC SYNDROME; HEPATIC STEATOSIS
AB Polyphenol-rich functional foods have shown promise in ameliorating NAFLD but the relative effectiveness and mechanisms of different polyphenols are largely unknown. In a model of steatosis using HepG2 hepatocytes exposed to palmitic acid, we investigated the effect of selected polyphenols (resveratrol, quercetin, catechin, cyanidin, kuromanin) and berberine. Exposure to palmitic acid produced steatosis and intracellular ROS production, which were prevented by all of the polyphenols and berberine, at 10 mu M. Palmitic acid produced a 245% increase in mRNA for inducible nitric oxide synthase (iNOS) that was almost completely prevented by all of the polyphenols (but not by berberine). Most of the polyphenols also partially inhibited palmitic acid-induced increases in markers of endoplasmic reticulum stress, and decreases in mitochondrial content and mitochondrial membrane potential. In conclusion, the polyphenols all similarly prevented steatosis, ROS generation and iNOS induction, and protected against ER stress and mitochondrial impairment.
C1 [Rafiei, Hossein; Omidian, Kosar; Bandy, Brian] Univ Saskatchewan, Nutr Div, Coll Pharm & Nutr, Saskatoon, SK, Canada.
C3 University of Saskatchewan
RP Bandy, B (corresponding author), 107 Wiggins Rd, Saskatoon, SK S7N 5E5, Canada.
EM b.bandy@usask.ca
RI Rafiei, Hossein/W-4825-2017
OI Rafiei, Hossein/0000-0002-4843-9261
FU Saskatchewan Health Research Foundation (SHRF); College of Pharmacy and
   Nutrition; University of Saskatchewan
FX This work was financed by a grant from the Saskatchewan Health Research
   Foundation (SHRF). Scholarships to HR and KO were provided by the
   College of Pharmacy and Nutrition and the University of Saskatchewan.
   H.R and B.B designed the research; H.R and K.O conducted the research;
   H.R analyzed the data and performed the statistical analyses; H.R wrote
   the manuscript; and B.B had primary responsibility for the final
   content. All authors read and approved the final manuscript.
CR Agnello M, 2008, CYTOTECHNOLOGY, V56, P145, DOI 10.1007/s10616-008-9143-2
   Aharoni-Simon M, 2011, LAB INVEST, V91, P1018, DOI 10.1038/labinvest.2011.55
   Ahn J, 2008, J HEPATOL, V49, P1019, DOI 10.1016/j.jhep.2008.08.012
   Aoun M, 2010, BRIT J NUTR, V104, P1760, DOI 10.1017/S0007114510002850
   Arunkumar E, 2013, PHARM BIOL, V51, P815, DOI 10.3109/13880209.2013.766896
   Austin S, 2012, J CELL SCI, V125, P4963, DOI 10.1242/jcs.113662
   Bagul PK, 2012, PHARMACOL RES, V66, P260, DOI 10.1016/j.phrs.2012.05.003
   Baur JA, 2006, NATURE, V444, P337, DOI 10.1038/nature05354
   Begriche K, 2013, HEPATOLOGY, V58, P1497, DOI 10.1002/hep.26226
   BROWN GC, 1994, FEBS LETT, V356, P295, DOI 10.1016/0014-5793(94)01290-3
   Cao J, 2012, MOL CELL BIOCHEM, V364, P115, DOI 10.1007/s11010-011-1211-9
   Chami M, 2008, MOL CELL, V32, P641, DOI 10.1016/j.molcel.2008.11.014
   Chatterjee S, 2013, J HEPATOL, V58, P778, DOI 10.1016/j.jhep.2012.11.035
   Cortez L, 2014, PRION, V8, P197, DOI 10.4161/pri.28938
   Cottet-Rousselle C, 2011, CYTOM PART A, V79A, P405, DOI 10.1002/cyto.a.21061
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   de Oliveira PRB, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0143721
   Ekhlasi G., 2016, INT J VITAM NUTR RES, V14, P1
   Emamat H, 2016, J DIABETES METAB DIS, V15, DOI 10.1186/s40200-016-0248-4
   Enos RT, 2014, J NUTR BIOCHEM, V25, P600, DOI 10.1016/j.jnutbio.2014.01.011
   Faghihzadeh F, 2014, NUTR RES, V34, P837, DOI 10.1016/j.nutres.2014.09.005
   Ferreira Nelson, 2015, Biochem Biophys Rep, V3, P123, DOI 10.1016/j.bbrep.2015.07.019
   Fujita K, 2010, ALCOHOL CLIN EXP RES, V34, pS18, DOI 10.1111/j.1530-0277.2008.00756.x
   García-Ruiz I, 2006, HEPATOLOGY, V44, P581, DOI 10.1002/hep.21313
   García-Ruiz I, 2015, DIS MODEL MECH, V8, P183, DOI 10.1242/dmm.018234
   Glisan SL, 2016, J NUTR BIOCHEM, V37, P60, DOI 10.1016/j.jnutbio.2016.07.009
   Gu YY, 2014, EUR J NUTR, V53, P149, DOI 10.1007/s00394-013-0510-1
   Guo HH, 2014, NUTRITION, V30, P198, DOI 10.1016/j.nut.2013.07.023
   Handschin C, 2007, J CLIN INVEST, V117, P3463, DOI 10.1172/JCI31785
   Hiramitsu M, 2014, SCI REP-UK, V4, DOI 10.1038/srep03708
   Ip P, 2017, PROTEIN ENG DES SEL, V30, P431, DOI 10.1093/protein/gzx025
   Iwakiri Y, 2015, TRENDS PHARMACOL SCI, V36, P524, DOI 10.1016/j.tips.2015.05.001
   Jung CH, 2013, PHYTOTHER RES, V27, P139, DOI 10.1002/ptr.4687
   Jung TW, 2012, BIOCHEM BIOPH RES CO, V422, P229, DOI 10.1016/j.bbrc.2012.04.129
   Kim WS, 2009, AM J PHYSIOL-ENDOC M, V296, pE812, DOI 10.1152/ajpendo.90710.2008
   Kobori M, 2011, MOL NUTR FOOD RES, V55, P530, DOI 10.1002/mnfr.201000392
   Kuo JJ, 2012, INT J MOL MED, V30, P643, DOI 10.3892/ijmm.2012.1020
   Kuzuhara T, 2008, CANCER LETT, V261, P12, DOI 10.1016/j.canlet.2007.10.037
   Lagouge M, 2006, CELL, V127, P1109, DOI 10.1016/j.cell.2006.11.013
   Lim JH, 2009, CELL SIGNAL, V21, P169, DOI 10.1016/j.cellsig.2008.10.004
   Liu JF, 2011, PHYTOTHER RES, V25, P588, DOI 10.1002/ptr.3305
   Liu YT, 2009, J PHARM SCI-US, V98, P4391, DOI 10.1002/jps.21721
   Ly JD, 2003, APOPTOSIS, V8, P115, DOI 10.1023/A:1022945107762
   Mantena SK, 2008, FREE RADICAL BIO MED, V44, P1259, DOI 10.1016/j.freeradbiomed.2007.12.029
   Mantena SK, 2009, BIOCHEM J, V417, P183, DOI 10.1042/BJ20080868
   Masterjohn C, 2012, NUTR REV, V70, P41, DOI 10.1111/j.1753-4887.2011.00440.x
   McAvoy N, 2007, S AFR J DIABETES VAS, V4, P9
   Nassir F, 2014, INT J MOL SCI, V15, P8713, DOI 10.3390/ijms15058713
   Navarro LA, 2015, J HEPATOL, V62, P412, DOI 10.1016/j.jhep.2014.09.015
   Noori M, 2017, J SCI FOOD AGR, V97, P2327, DOI 10.1002/jsfa.8042
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Pagliassotti MJ, 2012, ANNU REV NUTR, V32, P17, DOI 10.1146/annurev-nutr-071811-150644
   Pan QR, 2015, NUTR RES, V35, P576, DOI 10.1016/j.nutres.2015.05.006
   Pereira R. R., 2016, OXIDATIVE MED CELLUL, V2016
   Pirillo A, 2015, ATHEROSCLEROSIS, V243, P449, DOI 10.1016/j.atherosclerosis.2015.09.032
   Pu P, 2012, ARCH BIOCHEM BIOPHYS, V518, P61, DOI 10.1016/j.abb.2011.11.026
   Rafiei H, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600781
   Rayamajhi N., 2013, OXIDATIVE MED CELLUL, V2013
   Ribeiro PS, 2004, AM J GASTROENTEROL, V99, P1708, DOI 10.1111/j.1572-0241.2004.40009.x
   Ricchi M, 2009, J GASTROEN HEPATOL, V24, P830, DOI 10.1111/j.1440-1746.2008.05733.x
   Rodriguez-Mateos A, 2014, ARCH TOXICOL, V88, P1803, DOI 10.1007/s00204-014-1330-7
   Roy D, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0133012
   Sakata R, 2013, INT J MOL MED, V32, P989, DOI 10.3892/ijmm.2013.1503
   Santamarina AB, 2015, J NUTR BIOCHEM, V26, P1348, DOI 10.1016/j.jnutbio.2015.07.002
   Sastre-Serra J, 2012, INT J BIOCHEM CELL B, V44, P1901, DOI 10.1016/j.biocel.2012.07.012
   Sitepu IR, 2012, J MICROBIOL METH, V91, P321, DOI 10.1016/j.mimet.2012.09.001
   Spruss A, 2011, ANTIOXID REDOX SIGN, V14, P2121, DOI 10.1089/ars.2010.3263
   Spruss A, 2009, HEPATOLOGY, V50, P1094, DOI 10.1002/hep.23122
   Tan Y, 2017, WORLD J GASTROENTERO, V23, P3805, DOI 10.3748/wjg.v23.i21.3805
   Tang XL, 2015, J AGR FOOD CHEM, V63, P552, DOI 10.1021/jf504926n
   Tilg H, 2010, HEPATOLOGY, V52, P1836, DOI 10.1002/hep.24001
   Visioli F, 2011, CRIT REV FOOD SCI, V51, P524, DOI 10.1080/10408391003698677
   Vitaglione P, 2010, HEPATOLOGY, V52, P1652, DOI 10.1002/hep.23902
   Wang D, 2006, ENDOCRINOLOGY, V147, P943, DOI 10.1210/en.2005-0570
   Watson R., 2013, POLYPHENOLS HUMAN HL
   Wieckowska A, 2006, HEPATOLOGY, V44, P27, DOI 10.1002/hep.21223
   Willy JA, 2015, MOL BIOL CELL, V26, P2190, DOI 10.1091/mbc.E15-01-0036
   Wu SS, 2017, MOL NUTR FOOD RES, V61, DOI [10.1002/mnfr.201600858, 10.1002/mnfr.201770044]
   Xiao J, 2014, EUR J NUTR, V53, P187, DOI 10.1007/s00394-013-0516-8
   Xu J, 2011, J HEPATOL, V55, P673, DOI 10.1016/j.jhep.2010.12.034
   Zhang S, 2013, FOOD CHEM, V141, P2108, DOI 10.1016/j.foodchem.2013.05.019
   Zhang XQ, 2014, WORLD J GASTROENTERO, V20, P1768, DOI 10.3748/wjg.v20.i7.1768
   Zhang ZK, 2016, SCI REP-UK, V6, DOI 10.1038/srep20300
   Zou X, 2014, ANTIOXID REDOX SIGN, V21, P1557, DOI 10.1089/ars.2013.5538
NR 85
TC 19
Z9 21
U1 2
U2 76
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD MAY
PY 2018
VL 44
BP 173
EP 182
DI 10.1016/j.jff.2018.02.033
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA GC8GE
UT WOS:000430030900021
DA 2025-06-11
ER

PT J
AU Sepanjnia, K
   Modabbernia, A
   Ashrafi, M
   Modabbernia, MJ
   Akhondzadeh, S
AF Sepanjnia, Khatereh
   Modabbernia, Amirhossein
   Ashrafi, Mandana
   Modabbernia, Mohammad-Jafar
   Akhondzadeh, Shahin
TI Pioglitazone Adjunctive Therapy for Moderate-to-Severe Major Depressive
   Disorder: Randomized Double-Blind Placebo-Controlled Trial
SO NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE PPAR-gamma; pioglitazone; major depressive disorder; adjunctive therapy;
   thiazolidinedione; randomized controlled trial
ID PPAR-GAMMA; CLINICAL-TRIAL; ADD-ON; RECEPTOR; ROSIGLITAZONE; OUTCOMES;
   STRESS; BRAIN; NEUROINFLAMMATION; AUGMENTATION
AB Thiazolidinediones have shown antidepressant effect in animal studies, as well as in some uncontrolled studies evaluating human subjects with concurrent major depressive disorder (MDD) and metabolic syndrome. Although these drugs are insulin sensitizers, they also have important anti-inflammatory, neuroprotective, and anti-excitotoxic properties. Thus, we hypothesized that they would show antidepressant effect in patients with MDD even if it was not accompanied by metabolic disturbances. In this double-blind placebo-controlled study, 40 patients with MDD (DSM-IV-TR) and Hamilton depression rating scale-17 (Ham-D) score >= 22 were randomized to citalopram plus pioglitazone (15 mg every 12 h) (n = 20) or citalopram plus placebo (n 20) for 6 weeks. Patients were evaluated using Ham-D (weeks 0, 2, 4, 6). Repeated-measure analysis of variance (ANOVA) and analysis of covariance were used for comparison of scores between the two groups. Treatment response (>= 50% reduction in Ham-D score), remission (Ham-D score <= 7), and early improvement (>= 20% reduction in Ham-D score within the first 2 weeks) were compared between the two groups using Fisher's exact test. Pioglitazone showed superiority over placebo during the course of the trial (F(1, 38) = 9.483, p = 0.004). Patients in the pioglitazone group had significantly lower scores at all time points than the placebo group (P<0.01). Frequency of early improvement, response (week 6), and remission was significantly higher in the pioglitazone group (95%, 95%, 45%, respectively) than in the placebo (30%, 40%, 15% respectively) group (P<0.001, <0.001, 0.04, respectively). Frequency of side effects was similar between the two groups. Pioglitazone is a safe and effective adjunctive short-term treatment in patients with moderate-to-severe MDD even in the absence of metabolic syndrome and diabetes (http://clinicaltrials.gov/ct2/show/NCT01109030). Neuropsychopharmacology (2012) 37, 2093-2100; doi:10.1038/npp.2012.58; published online 2 May 2012
C1 [Sepanjnia, Khatereh; Modabbernia, Amirhossein; Ashrafi, Mandana; Akhondzadeh, Shahin] Univ Tehran Med Sci, Roozbeh Psychiat Hosp, Psychiat Res Ctr, Tehran 13337, Iran.
   [Modabbernia, Mohammad-Jafar] Guilan Univ Med Sci, Dept Psychiat, Guilan, Iran.
C3 Tehran University of Medical Sciences; Guilan University of Medical
   Sciences
RP Akhondzadeh, S (corresponding author), Univ Tehran Med Sci, Roozbeh Psychiat Hosp, Psychiat Res Ctr, S Kargar St, Tehran 13337, Iran.
EM s.akhond@neda.net
RI Modabbernia, Amirhossein/H-3709-2014; Akhondzadeh, Shahin/F-2914-2018
OI Akhondzadeh, Shahin/0000-0002-2277-5101
FU Tehran University of Medical Sciences [9476]
FX This study was Dr Khatereh Sepanjnia's postgraduate thesis toward
   qualification for the Iranian Board of Psychiatry under the supervision
   of Prof. Shahin Akhondzadeh. This study was supported by a grant from
   Tehran University of Medical Sciences to Prof. Shahin Akhondzadeh (Grant
   No. 9476).
CR Abolfazli R, 2011, DEPRESS ANXIETY, V28, P297, DOI 10.1002/da.20801
   Ahmed AAE, 2009, BEHAV PHARMACOL, V20, P635, DOI 10.1097/FBP.0b013e328331b9bf
   Akhondzadeh S, 2009, DEPRESS ANXIETY, V26, P607, DOI 10.1002/da.20589
   Apler A, 2011, BMJ OPEN, V1, DOI 10.1136/bmjopen-2011-000106
   Berlie HD, 2007, DIABETES RES CLIN PR, V76, P279, DOI 10.1016/j.diabres.2006.09.010
   Blier P, 2010, AM J PSYCHIAT, V167, P281, DOI 10.1176/appi.ajp.2009.09020186
   Blier P, 2009, EUR NEUROPSYCHOPHARM, V19, P457, DOI 10.1016/j.euroneuro.2009.01.015
   Budni J, 2011, J PSYCHOPHA IN PRESS
   Chen CY, 2010, GEN HOSP PSYCHIAT, V32, p647e7
   Fava M, 2006, PSYCHOTHER PSYCHOSOM, V75, P139, DOI 10.1159/000091771
   García-Bueno B, 2005, PSYCHOPHARMACOLOGY, V180, P513, DOI 10.1007/s00213-005-2195-5
   García-Bueno B, 2007, NEUROPSYCHOPHARMACOL, V32, P1251, DOI 10.1038/sj.npp.1301252
   García-Bueno B, 2010, INT J NEUROPSYCHOPH, V13, P1411, DOI 10.1017/S1461145710000970
   Geldmacher DS, 2011, ARCH NEUROL-CHICAGO, V68, P45, DOI 10.1001/archneurol.2010.229
   Heneka MT, 2007, BBA-MOL CELL BIOL L, V1771, P1031, DOI 10.1016/j.bbalip.2007.04.016
   Henkel V, 2009, J AFFECT DISORDERS, V115, P439, DOI 10.1016/j.jad.2008.10.011
   Jeong EA, 2011, EXP NEUROL, V232, P195, DOI 10.1016/j.expneurol.2011.09.001
   Jope RS, 2011, FRONT MOL NEUROSCI, V4, DOI 10.3389/fnmol.2011.00016
   Joyce PR, 2002, AUST NZ J PSYCHIAT, V36, P384, DOI 10.1046/j.1440-1614.2001.01026.x
   Kaiser CC, 2009, J NEUROIMMUNOL, V211, P124, DOI 10.1016/j.jneuroim.2009.04.011
   Karege F, 2012, J AFFECT DISORDERS, V136, P185, DOI 10.1016/j.jad.2011.09.024
   Kemp DE, 2012, J AFFECT DISORDERS, V136, P1164, DOI 10.1016/j.jad.2011.06.033
   Kemp DE, 2009, AM J PSYCHIAT, V166, P619, DOI 10.1176/appi.ajp.2008.08081195
   Kim EJ, 2002, BRAIN RES, V941, P1, DOI 10.1016/S0006-8993(02)02480-0
   Kim JM, 2011, J AFFECT DISORDERS, V129, P183, DOI 10.1016/j.jad.2010.09.007
   Maes M, 1999, J CLIN PSYCHOPHARM, V19, P177, DOI 10.1097/00004714-199904000-00014
   Marcus RN, 2008, J CLIN PSYCHOPHARM, V28, P156, DOI 10.1097/JCP.0b013e31816774f9
   Miller BW, 2011, ANN PHARMACOTHER, V45, P1416, DOI 10.1345/aph.1Q238
   Müller N, 2006, MOL PSYCHIATR, V11, P680, DOI 10.1038/sj.mp.4001805
   Munhoz CD, 2008, BRAZ J MED BIOL RES, V41, P1037, DOI 10.1590/S0100-879X2008001200001
   Nelson JC, 2004, BIOL PSYCHIAT, V55, P296, DOI 10.1016/j.biopsych.2003.08.007
   Ponce-Lopez T, 2011, BRAIN RES, V1426, P73, DOI 10.1016/j.brainres.2011.09.056
   Rasgon NL, 2010, THESCIENTIFICWORLDJO, V10, P321, DOI 10.1100/tsw.2010.32
   Rosa AO, 2008, PROG NEURO-PSYCHOPH, V32, P1549, DOI 10.1016/j.pnpbp.2008.05.020
   Rush AJ, 2011, AM J PSYCHIAT, V168, P689, DOI 10.1176/appi.ajp.2011.10111645
   Sadaghiani MS, 2011, BEHAV BRAIN RES, V224, P336, DOI 10.1016/j.bbr.2011.06.011
   Schatzberg AF, 2008, CNS SPECTRUMS, V13, P1
   Spiegelman BM, 1998, DIABETES, V47, P507, DOI 10.2337/diabetes.47.4.507
   Toyomoto M, 2004, FEBS LETT, V562, P211, DOI 10.1016/S0014-5793(04)00246-7
   Trivedi Madhukar H, 2006, J Psychiatr Pract, V12, P205, DOI 10.1097/00131746-200607000-00002
   Trivedi MH, 2011, J CLIN PSYCHIAT, V72, P677, DOI 10.4088/JCP.10m06743
   Trivedi MH, 2006, AM J PSYCHIAT, V163, P28, DOI 10.1176/appi.ajp.163.1.28
   van Calker D, 2009, J AFFECT DISORDERS, V114, P243, DOI 10.1016/j.jad.2008.07.023
   Vlckova V, 2010, J EVAL CLIN PRACT, V16, P1124, DOI 10.1111/j.1365-2753.2009.01280.x
   Warden Diane, 2007, Curr Psychiatry Rep, V9, P449, DOI 10.1007/s11920-007-0061-3
NR 45
TC 119
Z9 127
U1 0
U2 16
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0893-133X
EI 1740-634X
J9 NEUROPSYCHOPHARMACOL
JI Neuropsychopharmacology
PD AUG
PY 2012
VL 37
IS 9
BP 2093
EP 2100
DI 10.1038/npp.2012.58
PG 8
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 975FY
UT WOS:000306494600012
PM 22549115
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Jung, UJ
AF Jung, Un Ju
TI Sarcopenic Obesity: Involvement of Oxidative Stress and Beneficial Role
   of Antioxidant Flavonoids
SO ANTIOXIDANTS
LA English
DT Review
DE sarcopenic obesity; pathophysiology; oxidative stress; flavonoids
ID ENDOPLASMIC-RETICULUM STRESS; ACTIVATED PROTEIN-KINASE; SKELETAL-MUSCLE
   ATROPHY; DIET-INDUCED OBESITY; ONION PEEL EXTRACT; NF-KAPPA-B;
   MITOCHONDRIAL DYSFUNCTION; MOLECULAR-MECHANISMS; ADIPOSE-TISSUE; ER
   STRESS
AB Sarcopenic obesity, which refers to concurrent sarcopenia and obesity, is characterized by decreased muscle mass, strength, and performance along with abnormally excessive fat mass. Sarcopenic obesity has received considerable attention as a major health threat in older people. However, it has recently become a health problem in the general population. Sarcopenic obesity is a major risk factor for metabolic syndrome and other complications such as osteoarthritis, osteoporosis, liver disease, lung disease, renal disease, mental disease and functional disability. The pathogenesis of sarcopenic obesity is multifactorial and complicated, and it is caused by insulin resistance, inflammation, hormonal changes, decreased physical activity, poor diet and aging. Oxidative stress is a core mechanism underlying sarcopenic obesity. Some evidence indicates a protective role of antioxidant flavonoids in sarcopenic obesity, although the precise mechanisms remain unclear. This review summarizes the general characteristics and pathophysiology of sarcopenic obesity and focuses on the role of oxidative stress in sarcopenic obesity. The potential benefits of flavonoids in sarcopenic obesity have also been discussed.
C1 [Jung, Un Ju] Pukyong Natl Univ, Dept Food Sci & Nutr, 45 Yongso ro, Busan 48513, South Korea.
C3 Pukyong National University
RP Jung, UJ (corresponding author), Pukyong Natl Univ, Dept Food Sci & Nutr, 45 Yongso ro, Busan 48513, South Korea.
EM jungunju@naver.com
OI Jung, Un Ju/0000-0002-5441-460X
FU National Research Foundation of Korea (NRF) - Korea government
   [NRF-2017R1A2B4002675, 2019R1F1A1059945]
FX This research was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korea government, grant number
   NRF-2017R1A2B4002675 and 2019R1F1A1059945.
CR Ahn J, 2008, BIOCHEM BIOPH RES CO, V373, P545, DOI 10.1016/j.bbrc.2008.06.077
   Akpan I, 2009, INT J OBESITY, V33, P1265, DOI 10.1038/ijo.2009.162
   Pahlavani HA, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.811751
   Allen DL, 2011, MED SCI SPORT EXER, V43, P1828, DOI 10.1249/MSS.0b013e3182178bb4
   Guimaraes MSA, 2021, CLIN NUTR ESPEN, V41, P94, DOI 10.1016/j.clnesp.2020.11.004
   Alway SE, 2014, EXP GERONTOL, V50, P82, DOI 10.1016/j.exger.2013.11.011
   Anand A, 2022, J CLIN EXP HEPATOL, V12, P510, DOI 10.1016/j.jceh.2021.05.004
   Anand David Alexander Victor, 2016, Pharmacogn Rev, V10, P84, DOI 10.4103/0973-7847.194044
   [Anonymous], WHO OB REP
   [Anonymous], WHO CONTR GLOB OB EP
   Armandi A, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.716533
   Avgerinos KI, 2019, METABOLISM, V92, P121, DOI 10.1016/j.metabol.2018.11.001
   Baig MH, 2022, FRONT PHYSIOL, V13, DOI 10.3389/fphys.2022.876078
   Baldini F, 2021, LIFE SCI, V265, DOI 10.1016/j.lfs.2020.118812
   Bañuls C, 2017, INT J OBESITY, V41, P1556, DOI 10.1038/ijo.2017.147
   Bark TH, 1998, AM J PHYSIOL-ENDOC M, V275, pE118, DOI 10.1152/ajpendo.1998.275.1.E118
   Beccafico S, 2007, ANN NY ACAD SCI, V1100, P345, DOI 10.1196/annals.1395.037
   Bernardo BL, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011307
   Bernet JD, 2014, NAT MED, V20, P265, DOI 10.1038/nm.3465
   Bian AL, 2020, BMC MUSCULOSKEL DIS, V21, DOI 10.1186/s12891-020-03236-y
   Biesemann N, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-27614-8
   Boccellino M, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21165642
   Boden G, 2008, DIABETES, V57, P2438, DOI 10.2337/db08-0604
   Bodine SC, 2006, MED SCI SPORT EXER, V38, P1950, DOI 10.1249/01.mss.0000233797.24035.35
   BOFFOLI D, 1994, BBA-MOL BASIS DIS, V1226, P73, DOI 10.1016/0925-4439(94)90061-2
   Bonaldo P, 2013, DIS MODEL MECH, V6, P25, DOI 10.1242/dmm.010389
   Boschmann M, 2007, J AM COLL NUTR, V26, p389S, DOI 10.1080/07315724.2007.10719627
   Boudina S, 2014, EXP PHYSIOL, V99, P1168, DOI 10.1113/expphysiol.2014.081414
   Brack AS, 2007, SCIENCE, V317, P807, DOI 10.1126/science.1144090
   Braun KF, 2011, THESCIENTIFICWORLDJO, V11, P2348, DOI 10.1100/2011/471426
   Brüünsgaard H, 2003, IMMUNOL ALLERGY CLIN, V23, P15, DOI 10.1016/S0889-8561(02)00056-5
   Burke AC, 2018, J LIPID RES, V59, P1714, DOI 10.1194/jlr.M087387
   Canfora I, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11162566
   Cawthon PM, 2020, J AM GERIATR SOC, V68, P1429, DOI 10.1111/jgs.16517
   Chalil S, 2015, BIOCHEM BIOPH RES CO, V468, P702, DOI 10.1016/j.bbrc.2015.11.019
   Chang YC, 2020, ARCH BIOCHEM BIOPHYS, V692, DOI 10.1016/j.abb.2020.108511
   Chatree S, 2021, EXP BIOL MED, V246, P163, DOI 10.1177/1535370220962708
   Chen MM, 2017, J NUTR BIOCHEM, V46, P57, DOI 10.1016/j.jnutbio.2017.04.006
   Chen N, 2009, BBA-MOL CELL RES, V1793, P1516, DOI 10.1016/j.bbamcr.2008.12.013
   Chen TJ, 2018, ONCOL REP, V40, P1129, DOI 10.3892/or.2018.6453
   Cheng ZY, 2010, TRENDS ENDOCRIN MET, V21, P589, DOI 10.1016/j.tem.2010.06.005
   Choi C, 2020, NUTRIENTS, V12, DOI 10.3390/nu12103072
   Choi WH, 2018, MUSCLE NERVE, V58, P314, DOI 10.1002/mus.26133
   Choi WH, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201700218
   Chong WC, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18040771
   Chrienova Z, 2021, J ENZYM INHIB MED CH, V36, P1679, DOI 10.1080/14756366.2021.1955873
   Conboy IM, 2003, SCIENCE, V302, P1575, DOI 10.1126/science.1087573
   Cousin S, 2014, INVEST NEW DRUG, V32, P382, DOI 10.1007/s10637-013-0053-6
   Crespillo A, 2011, BRIT J PHARMACOL, V164, P1899, DOI 10.1111/j.1476-5381.2011.01477.x
   Cruz-Jentoft AJ, 2019, AGE AGEING, V48, P16, DOI 10.1093/ageing/afy169
   Cuthbertson D, 2004, FASEB J, V18, P422, DOI 10.1096/fj.04-2640fje
   Dalle S, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.01045
   DAW CK, 1988, J APPL PHYSIOL, V64, P2428, DOI 10.1152/jappl.1988.64.6.2428
   Deldicque L, 2013, FRONT PHYSIOL, V4, DOI 10.3389/fphys.2013.00236
   Diago-Galmés A, 2021, BIOLOGY-BASEL, V10, DOI 10.3390/biology10020093
   Donini LM, 2022, CLIN NUTR, V41, P990, DOI 10.1016/j.clnu.2021.11.014
   Emanuele E, 2016, NEUROENDOCRINOL LETT, V37, P213
   Figueiredo PA, 2008, BIOGERONTOLOGY, V9, P67, DOI 10.1007/s10522-007-9121-7
   Fulle S, 2005, EXP GERONTOL, V40, P189, DOI 10.1016/j.exger.2004.11.006
   Gan ML, 2022, NUTRIENTS, V14, DOI 10.3390/nu14091861
   Gan ML, 2022, NUTRIENTS, V14, DOI 10.3390/nu14081551
   García-Prat L, 2017, MOL CELL ENDOCRINOL, V445, P109, DOI 10.1016/j.mce.2016.08.021
   García-Prat L, 2016, NATURE, V529, P37, DOI 10.1038/nature16187
   Gonzalez A, 2021, OXID MED CELL LONGEV, V2021, DOI 10.1155/2021/4493817
   Green CJ, 2011, DIABETES, V60, P2810, DOI 10.2337/db11-0263
   Gregor MF, 2007, J LIPID RES, V48, P1905, DOI 10.1194/jlr.R700007-JLR200
   Gregor MF, 2009, DIABETES, V58, P693, DOI 10.2337/db08-1220
   Gruber ES, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0215915
   Gyawali B, 2016, MOL CLIN ONCOL, V5, P641, DOI 10.3892/mco.2016.1015
   Haddad F, 2006, J APPL PHYSIOL, V100, P1188, DOI 10.1152/japplphysiol.01227.2005
   Hamer M, 2015, INT J OBESITY, V39, P1717, DOI 10.1038/ijo.2015.124
   Harborne JB, 2000, PHYTOCHEMISTRY, V55, P481, DOI 10.1016/S0031-9422(00)00235-1
   Hashemzaei M, 2021, PREV NUTR FOOD SCI, V26, P67, DOI 10.3746/pnf.2021.26.1.67
   Heber David, 1996, American Journal of Clinical Nutrition, V64, p472S, DOI 10.1093/ajcn/64.3.472S
   Hemdan DII, 2009, J MED INVESTIG, V56, P26, DOI 10.2152/jmi.56.26
   Hirasaka K, 2013, J NUTR SCI VITAMINOL, V59, P317, DOI 10.3177/jnsv.59.317
   Hoek-van den Hil EF, 2015, GENES NUTR, V10, DOI 10.1007/s12263-015-0469-z
   Hong SH, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21020494
   Hostetler GL, 2017, ADV NUTR, V8, P423, DOI 10.3945/an.116.012948
   Hou LJ, 2021, J CELL MOL MED, V25, P9953, DOI 10.1111/jcmm.16810
   Hou XL, 2015, J NAT PROD, V78, P1689, DOI 10.1021/acs.jnatprod.5b00275
   Huang CH, 2010, J MED FOOD, V13, P391, DOI 10.1089/jmf.2009.1229
   Huang YJ, 2018, CELL PHYSIOL BIOCHEM, V49, P758, DOI 10.1159/000493040
   Huo FJ, 2022, FRONT PHYSIOL, V13, DOI 10.3389/fphys.2022.892749
   Hur J, 2019, PHYTOTHER RES, V33, P403, DOI 10.1002/ptr.6235
   Hyatt HW, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10040588
   Ibrahim Z, 2022, LIFE SCI SPACE RES, V34, P45, DOI 10.1016/j.lssr.2022.06.005
   Ishii S, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0162898
   Issa RI, 2012, PATHOBIOL AGING AGE, V2, DOI 10.3402/pba.v2i0.17470
   Jackisch L, 2020, J CLIN ENDOCR METAB, V105, P2905, DOI 10.1210/clinem/dgaa258
   Jang HC, 2011, ANN GERIATR MED RES, V15, P1, DOI 10.4235/jkgs.2011.15.1.1
   Jang YJ, 2017, ONCOTARGET, V8, P78300, DOI 10.18632/oncotarget.20962
   Janssen I, 2004, J AM GERIATR SOC, V52, P80, DOI 10.1111/j.1532-5415.2004.52014.x
   Jayarathne Shasika, 2017, Prev Nutr Food Sci, V22, P251, DOI 10.3746/pnf.2017.22.4.251
   Jiang H, 2020, J CLIN BIOCHEM NUTR, V67, P74, DOI 10.3164/jcbn.20-47
   Jiao GY, 2017, MOL MED REP, V15, P366, DOI 10.3892/mmr.2016.6014
   Jin KL, 2015, AGING DIS, V6, P1, DOI 10.14336/AD.2014.1210
   Jung CH, 2013, PHYTOTHER RES, V27, P139, DOI 10.1002/ptr.4687
   Jung Jaehoon, 2019, Korean Journal of Family Practice, V9, P230, DOI 10.21215/kjfp.2019.9.2.230
   Jung UJ, 2016, NUTRIENTS, V8, DOI 10.3390/nu8050305
   Kaeberlein M, 2015, SCIENCE, V350, P1191, DOI 10.1126/science.aad3267
   Kalyani RR, 2014, LANCET DIABETES ENDO, V2, P819, DOI 10.1016/S2213-8587(14)70034-8
   Kang SI, 2015, BIOL PHARM BULL, V38, P552, DOI 10.1248/bpb.b14-00700
   Kang SI, 2013, PHYTOTHER RES, V27, P131, DOI 10.1002/ptr.4683
   Katta A, 2010, AM J PHYSIOL-REG I, V299, pR1666, DOI 10.1152/ajpregu.00229.2010
   Kawasaki N, 2012, SCI REP-UK, V2, DOI 10.1038/srep00799
   Ke JY, 2016, MOL NUTR FOOD RES, V60, P313, DOI 10.1002/mnfr.201500379
   Ke JY, 2015, NUTR METAB, V12, DOI 10.1186/1743-7075-12-1
   Keller K, 2019, WIEN MED WOCHENSCHR, V169, P157, DOI 10.1007/s10354-018-0618-2
   Kim C, 2020, FOOD SCI BIOTECHNOL, V29, P1619, DOI 10.1007/s10068-020-00816-5
   Kim C, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041079
   Kim D, 2011, DIABETES OBES METAB, V13, P584, DOI 10.1111/j.1463-1326.2011.01379.x
   Kim H, 2013, GERIATR GERONTOL INT, V13, P458, DOI 10.1111/j.1447-0594.2012.00923.x
   Kim HI, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-17451-1
   Kim JW, 2023, MOL NUTR FOOD RES, V67, DOI 10.1002/mnfr.202200729
   Kim TN, 2013, J Korean Diabetes, V14, P166, DOI [10.4093/jkd.2013.14.4.166, DOI 10.4093/JKD.2013.14.4.166]
   Kim Y, 2018, J MED FOOD, V21, P551, DOI 10.1089/jmf.2017.4108
   Kim YS, 2012, J GERONTOL A-BIOL, V67, P1107, DOI 10.1093/gerona/gls071
   King D, 2015, J PEDIAT HEMATOL ONC, V37, P245, DOI 10.1097/MPH.0000000000000329
   Kobori M, 2016, MOL NUTR FOOD RES, V60, P300, DOI 10.1002/mnfr.201500595
   Kongara S, 2012, FRONT ONCOL, V2, DOI 10.3389/fonc.2012.00171
   Kou XJ, 2017, BIOMED PHARMACOTHER, V90, P311, DOI 10.1016/j.biopha.2017.03.070
   Kriete A, 2010, PLOS COMPUT BIOL, V6, DOI 10.1371/journal.pcbi.1000820
   Kubo H, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-23521-1
   KUPPUSAMY UR, 1992, BIOCHEM PHARMACOL, V44, P1307, DOI 10.1016/0006-2952(92)90531-M
   Kusminski CM, 2012, TRENDS ENDOCRIN MET, V23, P435, DOI 10.1016/j.tem.2012.06.004
   Kwak JY, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-26617-9
   Larsen RG, 2012, APPL PHYSIOL NUTR ME, V37, P88, DOI [10.1139/h11-135, 10.1139/H11-135]
   Le NH, 2014, MEDIAT INFLAMM, V2014, DOI 10.1155/2014/834294
   LeBrasseur NK, 2011, AM J PHYSIOL-ENDOC M, V300, pE3, DOI 10.1152/ajpendo.00512.2010
   Lee H, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19061693
   Lee JS, 2016, NUTR RES PRACT, V10, P175, DOI 10.4162/nrp.2016.10.2.175
   Lee JW, 2012, J LIPID RES, V53, P1277, DOI 10.1194/jlr.M022897
   Lee MS, 2017, FOOD NUTR RES, V61, DOI 10.1080/16546628.2017.1325307
   Lee SE, 2020, CALCIFIED TISSUE INT, V106, P124, DOI 10.1007/s00223-019-00623-z
   Leng QY, 2022, NUTR METAB, V19, DOI 10.1186/s12986-022-00672-6
   LEXELL J, 1995, J GERONTOL A-BIOL, V50, P11
   LEXELL J, 1988, J NEUROL SCI, V84, P275, DOI 10.1016/0022-510X(88)90132-3
   Li B, 2016, GENET MOL RES, V15, DOI 10.4238/gmr.15017117
   Li F, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01366
   Li H, 2008, J MOL MED, V86, P1113, DOI 10.1007/s00109-008-0373-8
   Li HD, 2021, OBES RES CLIN PRACT, V15, P485, DOI 10.1016/j.orcp.2021.08.003
   Liang C, 2009, BIRTH DEFECTS RES B, V86, P377, DOI 10.1002/bdrb.20206
   Liesa M, 2013, CELL METAB, V17, P491, DOI 10.1016/j.cmet.2013.03.002
   Liguori I, 2018, CLIN INTERV AGING, V13, P757, DOI 10.2147/CIA.S158513
   Lin YH, 2022, ARCH OSTEOPOROS, V17, DOI 10.1007/s11657-022-01107-8
   Liu D, 2019, TRENDS FOOD SCI TECH, V91, P586, DOI 10.1016/j.tifs.2019.07.038
   Liu DJ, 2022, DOSE-RESPONSE, V20, DOI 10.1177/15593258221113791
   Liu M, 2015, HORTIC RES-ENGLAND, V2, DOI 10.1038/hortres.2015.11
   Liu P, 2016, MOL NEUROBIOL, V53, P7200, DOI 10.1007/s12035-015-9627-y
   López-Lázaro M, 2009, MINI-REV MED CHEM, V9, P31, DOI 10.2174/138955709787001712
   Lu CW, 2013, OBES RES CLIN PRACT, V7, pE301, DOI 10.1016/j.orcp.2012.02.003
   Mafi F, 2019, J AGING PHYS ACTIV, V27, P384, DOI 10.1123/japa.2017-0389
   Malenfant Jason H, 2019, J Glob Health Rep, V3, DOI 10.29392/joghr.3.e2019045
   Mammucari C, 2007, CELL METAB, V6, P458, DOI 10.1016/j.cmet.2007.11.001
   Maurya AK, 2015, TUMOR BIOL, V36, P8913, DOI 10.1007/s13277-015-3634-5
   McCarthy JJ, 2010, CURR OPIN CLIN NUTR, V13, P230, DOI 10.1097/MCO.0b013e32833781b5
   Meador BM, 2015, J FRALITY AGING, V4, P209, DOI 10.14283/jfa.2015.58
   Meng SJ, 2010, INT J MOL SCI, V11, P1509, DOI 10.3390/ijms11041509
   Merli M, 2013, METAB BRAIN DIS, V28, P281, DOI 10.1007/s11011-012-9365-z
   Mielgo-Ayuso J, 2014, BRIT J NUTR, V111, P1263, DOI 10.1017/S0007114513003784
   Minet AD, 2012, BIOGERONTOLOGY, V13, P277, DOI 10.1007/s10522-012-9372-9
   Mir O, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0037563
   Mirza KA, 2014, J CACHEXIA SARCOPENI, V5, P339, DOI 10.1007/s13539-014-0139-9
   Molino S, 2016, J NUTR HEALTH AGING, V20, P780, DOI 10.1007/s12603-015-0631-8
   Moon HS, 2007, OBESITY, V15, P2571, DOI 10.1038/oby.2007.309
   Moon J, 2013, FOOD CHEM TOXICOL, V58, P347, DOI 10.1016/j.fct.2013.05.006
   Moreno-Ulloa A, 2018, EUR J PHARMACOL, V822, P95, DOI 10.1016/j.ejphar.2018.01.014
   Moreno-Ulloa A, 2015, J GERONTOL A-BIOL, V70, P1370, DOI 10.1093/gerona/glu131
   Mou QH, 2022, ARCH BIOCHEM BIOPHYS, V723, DOI 10.1016/j.abb.2022.109217
   Mukai R, 2016, J NUTR BIOCHEM, V31, P67, DOI 10.1016/j.jnutbio.2016.02.001
   Mukai R, 2010, J NAT PROD, V73, P1708, DOI 10.1021/np100240y
   Munguia L, 2020, FOOD BIOSCI, V37, DOI 10.1016/j.fbio.2020.100710
   Murase T, 2005, AM J PHYSIOL-REG I, V288, pR708, DOI 10.1152/ajpregu.00693.2004
   Myoung HJ, 2010, ARCH PHARM RES, V33, P1741, DOI 10.1007/s12272-010-1105-5
   Nations U, World population projected to reach 9.8 billion in 2050, and 11.2 billion in 2100
   Nilwik R, 2013, EXP GERONTOL, V48, P492, DOI 10.1016/j.exger.2013.02.012
   O'Leary MF, 2013, AM J PHYSIOL-CELL PH, V304, pC422, DOI 10.1152/ajpcell.00240.2012
   O'Neill HM, 2013, MOL CELL ENDOCRINOL, V366, P135, DOI 10.1016/j.mce.2012.06.019
   O'Rourke RW, 2021, OBESITY, V29, P645, DOI 10.1002/oby.23099
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Ogata T, 2009, MECH AGEING DEV, V130, P328, DOI 10.1016/j.mad.2009.02.001
   Otsuka Y, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.912217
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Panche AN, 2016, J NUTR SCI, V5, DOI 10.1017/jns.2016.41
   Pellegrini M, 2014, GENES NUTR, V9, DOI 10.1007/s12263-014-0425-3
   Pfeuffer M, 2013, NUTR METAB CARDIOVAS, V23, P403, DOI 10.1016/j.numecd.2011.08.010
   Pi-Sunyer FX, 1998, AM J CLIN NUTR, V68, P899
   Pomiès P, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0160092
   Popko K, 2010, EUR J MED RES, V15, P120
   Prado CMM, 2009, CLIN CANCER RES, V15, P2920, DOI 10.1158/1078-0432.CCR-08-2242
   Purcell SA, 2021, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.583825
   Qiao Y, 2022, FRONT MICROBIOL, V12, DOI 10.3389/fmicb.2021.805827
   Qiu P, 2017, TOXICOL LETT, V274, P31, DOI 10.1016/j.toxlet.2017.04.009
   Ren B, 2016, EUR J PHARMACOL, V773, P13, DOI 10.1016/j.ejphar.2016.01.002
   Renno WM, 2012, N-S ARCH PHARMACOL, V385, P807, DOI 10.1007/s00210-012-0758-7
   Rocchetti G, 2022, COMPR REV FOOD SCI F, V21, P811, DOI 10.1111/1541-4337.12921
   Rooyackers OE, 1996, P NATL ACAD SCI USA, V93, P15364, DOI 10.1073/pnas.93.26.15364
   Roth SM, 2000, ANAT REC, V260, P351, DOI 10.1002/1097-0185(200012)260:4<350::AID-AR30>3.0.CO;2-6
   Ryan Alice S, 2021, JCSM Clin Rep, V6, P137, DOI 10.1002/crt2.43
   Sa BK, 2017, J MED FOOD, V20, P1047, DOI 10.1089/jmf.2017.3970
   Sack C, 2022, J CLIN MED, V11, DOI 10.3390/jcm11010277
   Sandri M, 2004, CELL, V117, P399, DOI 10.1016/S0092-8674(04)00400-3
   Santilli V, 2014, CLIN CASES MINER BON, V11, P177, DOI 10.11138/ccmbm/2014.11.3.177
   Saul D, 2016, J NUTR METAB, V2016, DOI 10.1155/2016/3703216
   Schiaffino S, 2011, PHYSIOL REV, V91, P1447, DOI 10.1152/physrev.00031.2010
   Sebastián D, 2012, P NATL ACAD SCI USA, V109, P5523, DOI 10.1073/pnas.1108220109
   Seo D, 2022, OBESITY, V30, P2034, DOI 10.1002/oby.23512
   Seok JH, 2022, J VET SCI, V23, DOI 10.4142/jvs.22097
   Shanely RA, 2010, FREE RADICAL RES, V44, P224, DOI 10.3109/10715760903407293
   Sharma Pranav, 2015, Urol Oncol, V33, DOI 10.1016/j.urolonc.2015.01.011
   Shen YC, 2019, INT J OBESITY, V43, P355, DOI 10.1038/s41366-018-0138-6
   Sheng LL, 2018, FASEB J, V32, P6371, DOI 10.1096/fj.201800370R
   Shiota C, 2015, J NUTR SCI VITAMINOL, V61, P188, DOI 10.3177/jnsv.61.188
   Shirakawa T, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11091493
   Shukla S, 2014, CARCINOGENESIS, V35, P452, DOI 10.1093/carcin/bgt316
   Si HW, 2019, FASEB J, V33, P965, DOI [10.1096/fj.201800554rr, 10.1096/fj.201800554RR]
   Siddique YH, 2022, CHEM-BIOL INTERACT, V366, DOI 10.1016/j.cbi.2022.110120
   Sirago G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms232213823
   Snijders T, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00283
   Song W, 2023, GUT LIVER, V17, P130, DOI 10.5009/gnl220041
   Song YJ, 2022, FOOD FUNCT, V13, P2491, DOI [10.1039/d1fo03971g, 10.1039/D1FO03971G]
   Song Y, 2016, J MED FOOD, V19, P1111, DOI 10.1089/jmf.2016.3800
   Soussi A, 2022, CHEM-BIOL INTERACT, V368, DOI 10.1016/j.cbi.2022.110230
   Stephen WC, 2009, J NUTR HEALTH AGING, V13, P460, DOI 10.1007/s12603-009-0084-z
   Stewart LK, 2008, METABOLISM, V57, pS39, DOI 10.1016/j.metabol.2008.03.003
   Stitt TN, 2004, MOL CELL, V14, P395, DOI 10.1016/S1097-2765(04)00211-4
   Sun BM, 2021, J NUTR, V151, P1717, DOI 10.1093/jn/nxab057
   Sun YS, 2019, FOOD CHEM TOXICOL, V133, DOI 10.1016/j.fct.2019.110780
   Suzuki T, 2016, MOLECULES, V21, DOI 10.3390/molecules21101305
   Szentesi P, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/4617801
   Takahashi H, 2017, EXP GERONTOL, V92, P56, DOI 10.1016/j.exger.2017.02.075
   Tan BHL, 2009, CLIN CANCER RES, V15, P6973, DOI 10.1158/1078-0432.CCR-09-1525
   Tandon P, 2020, CLIN GASTROENTEROL H, V18, P1036, DOI 10.1016/j.cgh.2019.09.030
   Terman A, 2006, ANTIOXID REDOX SIGN, V8, P197, DOI 10.1089/ars.2006.8.197
   Thornell LE, 2011, CURR OPIN CLIN NUTR, V14, P22, DOI 10.1097/MCO.0b013e3283412260
   Tierney MT, 2014, NAT MED, V20, P1182, DOI 10.1038/nm.3656
   Tripathi YB, 2012, FRONT IMMUNOL, V3, DOI 10.3389/fimmu.2012.00240
   United Nations Department of Economic & Social Affairs Population Division, 2022, World Population Prospects
   van der Meer SFT, 2011, MUSCLE NERVE, V43, P212, DOI 10.1002/mus.21822
   VanderVeen BN, 2023, NUTRIENTS, V15, DOI 10.3390/nu15010102
   Verdijk LB, 2014, AGE, V36, P545, DOI 10.1007/s11357-013-9583-2
   Vrânceanu M, 2022, PLANTS-BASEL, V11, DOI 10.3390/plants11192524
   Wagenaar CA, 2021, CLIN NUTR, V40, P4422, DOI 10.1016/j.clnu.2021.01.005
   Wagers AJ, 2005, CELL, V122, P659, DOI 10.1016/j.cell.2005.08.021
   Wang DT, 2020, J GERONTOL A-BIOL, V75, P2081, DOI 10.1093/gerona/glaa214
   Wang H, 2011, CANCER LETT, V305, P40, DOI 10.1016/j.canlet.2011.02.023
   Wang H, 2016, BMC GERIATR, V16, DOI 10.1186/s12877-016-0386-z
   Wang XN, 2006, ENDOCRINOLOGY, V147, P4160, DOI 10.1210/en.2006-0251
   White TA, 2014, GERONTOLOGY, V60, P289, DOI 10.1159/000356740
   Wilkinson Thomas J, 2022, JCSM Rapid Commun, V5, P3, DOI 10.1002/rco2.47
   World Health Organization IOTF, 2000, AS PAC PERSP RED OB
   Wu JB, 2022, MOLECULES, V27, DOI 10.3390/molecules27030607
   Wu MQ, 2017, EUR J PHARMACOL, V795, P134, DOI 10.1016/j.ejphar.2016.12.006
   Wu Y, 2021, J CLIN TRANSL HEPATO, V9, P373, DOI 10.14218/JCTH.2021.00050
   Wu ZJ, 2022, NUTRIENTS, V14, DOI 10.3390/nu14183756
   Yan J, 2012, J NUTR BIOCHEM, V23, P716, DOI 10.1016/j.jnutbio.2011.03.014
   Yang W, 2007, J BIOL CHEM, V282, P3799, DOI 10.1074/jbc.M610185200
   Ye LY, 2015, FOOD CHEM, V172, P416, DOI 10.1016/j.foodchem.2014.09.090
   Yeh CH, 2022, J BIOMED SCI, V29, DOI 10.1186/s12929-022-00838-7
   Yoon MS, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00788
   Yoshida T, 2013, INT J BIOCHEM CELL B, V45, P2322, DOI 10.1016/j.biocel.2013.05.035
   Yoshioka Y, 2019, ARCH BIOCHEM BIOPHYS, V664, P157, DOI 10.1016/j.abb.2019.02.006
   Zeng ZZ, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.583478
   Zhang JD, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/4353510
   Zhang XQ, 2008, CELL, V135, P61, DOI 10.1016/j.cell.2008.07.043
   Zhang ZK, 2016, SCI REP-UK, V6, DOI 10.1038/srep20300
   Zhao ZQ, 2014, CANCER PREV RES, V7, P927, DOI 10.1158/1940-6207.CAPR-14-0067
   Zhou DJ, 2022, AGING-US, V14, P8633, DOI 10.18632/aging.204368
   Zhou JH, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111681
   Zhou QC, 2017, BBA-MOL BASIS DIS, V1863, P1282, DOI 10.1016/j.bbadis.2017.03.019
   Zou D, 2014, MED SCI SPORT EXER, V46, P2077, DOI 10.1249/MSS.0000000000000336
NR 272
TC 17
Z9 17
U1 17
U2 41
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAY 8
PY 2023
VL 12
IS 5
AR 1063
DI 10.3390/antiox12051063
PG 25
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA H2GE5
UT WOS:000994192600001
PM 37237929
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ma, LH
   Jiang, XL
   Wang, S
   Ning, J
AF Ma, Lihua
   Jiang, Xiaolian
   Wang, Song
   Ning, Jiang
TI Application of health self-management intervention program for metabolic
   syndrome patients in the bereaved population following the Wenchuan
   earthquake
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE metabolic syndrome; bereavement; self-management; intervention; RCT -
   randomized controlled trial
ID RISK
AB Background: The destructive Wenchuan earthquake has led to approximately 800,000 people being bereaved. In the previous cross-sectional study, we explored the long-term incidence of Metabolic Syndrome (MS) and studied its influencing factors among the bereaved population 12 years after the Wenchuan earthquake. Chronic disease self-management has become a recognized public health service. Studies have shown that demographic and genetic factors, stress, geographical environment, society, culture, dietary habits, lifestyle, and other aspects influence MS. Due to the Wenchuan earthquake being a serious stress event, the implementation of targeted interventions should be discussed further.Objectives: To verify the effect of applying a self-management intervention program for patients with MS among the bereaved population following the Wenchuan earthquake.Design: A randomized controlled trial (RCT) design was adopted.Participants: A total of 132 bereaved patients with MS following the Wenchuan earthquake constituted the sample.Methods: The study was based on the Cognitive-Phenomenological-Transaction, Chronic Disease Self-Management Program, and Patient Empowerment Conceptual Model, which combined with the latest evidence-based guidelines, were used to systematically evaluate cross-sectional results of this study that were used to construct a stress management-based health self-management intervention program and MS health self-management manual for bereaved patients with MS following the Wenchuan earthquake. In addition, we revised and completed a health self-management intervention program and health self-management manual for patients with MS by using the expert consultation method. General data were collected prior to intervention (T0). We collected the patients' MS disease-related physiological indicators before intervention (T0), after intervention (T1), and 2 months after intervention (T2). EipData3.1 software was used to input data in duplex and duplicate, and SPSS22.0 software was used for statistical analysis.Results: The variance analysis showed that the total score of healthy self-management behavior and the score of diet management, exercise management, drug management, and emotional management have intergroup effects, time effects, and group-time interaction effects (p < 0.05). When the differences between groups were further compared, we found that the total score and the score of six dimensions (excluding disease self-monitoring management) were higher than those of the control groups at T1 and T2, and the differences were statistically significant (p < 0.05).Conclusion: The intervention program of healthy self-management for patients with MS who come from bereaved families following the Wenchuan earthquake can effectively improve patients' health self-management behaviors.
C1 [Ma, Lihua; Jiang, Xiaolian; Wang, Song; Ning, Jiang] Sichuan Univ, West China Hosp, West China Sch Nursing, Chengdu, Peoples R China.
   [Ma, Lihua] Lanzhou Univ, Hosp 1, Lanzhou, Gansu, Peoples R China.
C3 Sichuan University; Lanzhou University
RP Jiang, XL (corresponding author), Sichuan Univ, West China Hosp, West China Sch Nursing, Chengdu, Peoples R China.
EM jiang_xiaolian@126.com
FU Natural Science Foundation of Gansu Province [21JR1RA106]; National
   Natural Science Foundation of China [72264022]; First Hospital of
   Lanzhou University [ldyyn2022-97]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This research granted
   from the Natural Science Foundation of Gansu Province (No. 21JR1RA106),
   National Natural Science Foundation of China (No.72264022) and the First
   Hospital of Lanzhou University doctoral research start-up fund
   (ldyyn2022-97).
CR Aktas MF, 2019, EUR J CLIN NUTR, V73, P805, DOI 10.1038/s41430-018-0371-z
   Athyros VG, 2005, DIABETES OBES METAB, V7, P397, DOI 10.1111/j.1463-1326.2004.00409.x
   Bullón-Vela V, 2020, NUTRITION, V71, DOI 10.1016/j.nut.2019.110620
   Carmassi C, 2020, FRONT PSYCHIATRY, V11, DOI 10.3389/fpsyt.2020.492006
   Chinese Experts, 2017, Consensus on Diagnosis and Treatment of Cardiovascular Disease with Insomnia
   Cooney LG, 2018, FERTIL STERIL, V110, P161, DOI 10.1016/j.fertnstert.2018.03.028
   Gathirua-Mwangi WG, 2017, CANCER CAUSE CONTROL, V28, P127, DOI 10.1007/s10552-016-0843-1
   Kohsari M, 2021, BIOMED RES INT, V2021, DOI 10.1155/2021/5584452
   Lee BJ, 2020, BMC ENDOCR DISORD, V20, DOI 10.1186/s12902-020-0510-0
   Marks S, 2016, WORKPLACE HEALTH SAF, V64, P543, DOI 10.1177/2165079916634712
   Nehus E, 2018, CURR OPIN PEDIATR, V30, P241, DOI 10.1097/MOP.0000000000000586
   Qianjin J., 2000, Medical Psychology
   [曲姗 Qu Shan], 2015, [中国心理卫生杂志, Chinese Mental Health Journal], V29, P939
   Rafiey H, 2019, COMMUNITY MENT HLT J, V55, P542, DOI 10.1007/s10597-019-00384-x
   Senhai Y., 2017, Prev Med, V29, P1193
   Shengnan M., 2017, Community metabolic syndrome intervention research based on chronic disease management model
   Shin NM, 2017, J CARDIOVASC NURS, V32, pE8, DOI 10.1097/JCN.0000000000000406
   Shomaker LB, 2017, DEPRESS ANXIETY, V34, P866, DOI 10.1002/da.22617
   State Council Information Office of the People's Republic of China, 2010, Wenchuan earthquake
   Williams J, 2016, TRIALS, V17, DOI 10.1186/s13063-016-1660-2
   Xie K, 2019, LIPIDS HEALTH DIS, V18, DOI 10.1186/s12944-019-1121-5
   Xinman D., 2010, A study on the bereavement, anxiety, depression and its influencing factors of the bereaved one year after the Wenchuan earthquake
   Yasha W., 2017, Chin J Dis Control, V21, P784
   Yongxiang M., 2010, Study on the effect of health self-management intervention for hypertension patients in Banfang community
   Zhai Yingfen X., 2015, China Med Herald, V12, P142
   Zhang GT, 2021, SCI TOTAL ENVIRON, V760, DOI 10.1016/j.scitotenv.2020.143349
   Zhihong N., 2019, A study on health self-management intervention in Xinjiang Kazakh patients with metabolic syndrome
NR 27
TC 0
Z9 0
U1 2
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD DEC 7
PY 2023
VL 11
AR 1277389
DI 10.3389/fpubh.2023.1277389
PG 15
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA CV0U5
UT WOS:001127902200001
PM 38145081
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cottone, S
   Lorito, MC
   Riccobene, R
   Nardi, E
   Mulè, G
   Buscemi, S
   Geraci, C
   Guarneri, M
   Arsena, R
   Cerasola, G
AF Cottone, Santina
   Lorito, Maria Carmela
   Riccobene, Raffaella
   Nardi, Emilio
   Mule, Giuseppe
   Buscemi, Silvio
   Geraci, Calogero
   Guarneri, Marco
   Arsena, Rosalia
   Cerasola, Giovanni
TI Oxidative stress, inflammation and cardiovascular disease in chronic
   renal failure
SO JOURNAL OF NEPHROLOGY
LA English
DT Review
DE oxidative stress; endothelium; atherosclerosis; renal failure
ID LEFT-VENTRICULAR HYPERTROPHY; OXIDANT STRESS; KIDNEY-DISEASE;
   ATHEROSCLEROSIS; MORTALITY; ASSOCIATION; DIALYSIS; LIPOPROTEIN;
   DYSFUNCTION; BIOMARKERS
AB Traditional risk factors such as hypertension, diabetes, dyslipidemia, obesity and metabolic syndrome, as well as additional nontraditional risk factors, can damage the kidney directly and by promoting intrarenal atherogenesis. Evidence indicates that increased oxidative stress and inflammation may mediate most of the effects of risk factors on the kidney. Clinical studies have demonstrated a relationship between oxidative stress and inflammatory biomarkers, and a few studies indicate an inverse correlation of oxidative stress biomarkers with estimated glomerular filtration rate (eGFR). Further, surrogate indexes of atherosclerosis such as intima-media thickness and aortic pulse wave velocity have been demonstrated to be related to plasma concentrations of markers of endothelial activation, inflammation and fibrosis in patients with different stages of chronic kidney disease (CKD). Moreover, plasma concentrations of high-sensitivity Creactive protein have been shown to be increased and related to left ventricular mass in CKD individuals having left ventricular hypertrophy. In contrast, in these patients, decreases in fetuin-A plasma levels have been reported. Considering the complex background of the pathophysiological changes characterizing CKD patients, we can consider cardiovascular disease a multifactorial complication of CKD.
C1 [Cottone, Santina; Geraci, Calogero; Guarneri, Marco; Arsena, Rosalia] Univ Palermo, Chair Nephrol, Palermo, Italy.
   [Cottone, Santina; Geraci, Calogero; Guarneri, Marco; Arsena, Rosalia] Univ Palermo, Chair Nephrol, Unit Renal Dis & Hypertens, Palermo, Italy.
   [Lorito, Maria Carmela; Riccobene, Raffaella; Nardi, Emilio; Mule, Giuseppe; Buscemi, Silvio; Cerasola, Giovanni] Univ Palermo, Chair Internal Med, Dept Internal Med, Palermo, Italy.
C3 University of Palermo; University of Palermo; University of Palermo
RP Cottone, S (corresponding author), Via Vespro 129, I-90127 Palermo, Italy.
EM sancott@tin.it
RI Nardi, Emilio/AAB-9614-2022; MULE', GIUSEPPE/AAM-5435-2020; buscemi,
   silvio/K-9662-2016
OI Riccobene, Raffaella/0009-0005-2712-1616; Nardi,
   Emilio/0000-0003-1844-0285; GUARNERI, Marco/0000-0002-0447-6861;
   buscemi, silvio/0000-0003-0730-7649; Mulè&apos;,
   Giuseppe/0000-0002-8705-4911; Mule', Giuseppe/0000-0002-8500-8671;
   cottone, santina/0000-0001-6226-5846
CR Abrass CK, 2004, AM J NEPHROL, V24, P46, DOI 10.1159/000075925
   Ares Mikko P S, 2002, BMC Immunol, V3, P13, DOI 10.1186/1471-2172-3-13
   Arici M, 2001, KIDNEY INT, V59, P407, DOI 10.1046/j.1523-1755.2001.059002407.x
   Chade AR, 2003, KIDNEY INT, V64, P962, DOI 10.1046/j.1523-1755.2003.00170.x
   Chade AR, 2003, AM J HYPERTENS, V16, P111, DOI 10.1016/S08957061(02)03202-8
   Cottone S, 2007, J HYPERTENS, V25, pS64
   Cottone S, 2007, CLIN NEPHROL, V67, P209
   Covic A, 2005, J NEPHROL, V18, P388
   DEVEREUX RB, 1986, AM J CARDIOL, V57, P450, DOI 10.1016/0002-9149(86)90771-X
   Dounousi E, 2006, AM J KIDNEY DIS, V48, P752, DOI 10.1053/j.ajkd.2006.08.015
   Hermans MMH, 2007, KIDNEY INT, V72, P202, DOI 10.1038/sj.ki.5002178
   Himmelfarb J, 2002, KIDNEY INT, V62, P1524, DOI 10.1046/j.1523-1755.2002.00600.x
   Kamanna VS, 1998, HISTOL HISTOPATHOL, V13, P169, DOI 10.14670/HH-13.169
   Kamanna VS, 1997, CURR OPIN NEPHROL HY, V6, P205, DOI 10.1097/00041552-199705000-00001
   Kaysen GA, 2004, J AM SOC NEPHROL, V15, P538, DOI 10.1097/01.ASN.0000111744.00916.E6
   Ketteler M, 2003, LANCET, V361, P827, DOI 10.1016/S0140-6736(03)12710-9
   Liuzzo G, 2001, Rays, V26, P221
   Lombardo A, 2004, CIRCULATION, V109, P3158, DOI 10.1161/01.CIR.0000130786.28008.56
   Mallamaci F, 2005, KIDNEY INT, V67, P2330, DOI 10.1111/j.1523-1755.2005.00338.x
   Mancia G, 2007, EUR HEART J, V28, P1462, DOI 10.1093/eurheartj/ehm236
   Mathur S, 2002, CURR OPIN NEPHROL HY, V11, P141, DOI 10.1097/00041552-200203000-00003
   Merx MW, 2005, J AM SOC NEPHROL, V16, P3357, DOI 10.1681/ASN.2005040365
   Oberg BP, 2004, KIDNEY INT, V65, P1009, DOI 10.1111/j.1523-1755.2004.00465.x
   Varadhachary AS, 2001, CELL IMMUNOL, V213, P45, DOI 10.1006/cimm.2001.1855
   Zimmermann J, 1999, KIDNEY INT, V55, P648, DOI 10.1046/j.1523-1755.1999.00273.x
   Zoccali C, 2000, J HYPERTENS, V18, P1207, DOI 10.1097/00004872-200018090-00006
NR 26
TC 120
Z9 128
U1 1
U2 20
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1121-8428
EI 1724-6059
J9 J NEPHROL
JI J. Nephrol.
PD MAR-APR
PY 2008
VL 21
IS 2
BP 175
EP 179
PG 5
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 317TC
UT WOS:000257041900006
PM 18446711
DA 2025-06-11
ER

PT J
AU Eisenmann, JC
AF Eisenmann, Joey C.
TI Insight into the causes of the recent secular trend in pediatric
   obesity: Common sense does not always prevail for complex,
   multi-factorial phenotypes
SO PREVENTIVE MEDICINE
LA English
DT Review
DE obesity; prenatal environmental; macrosomia; gestational diabetes;
   physical activity; diet
ID BODY-MASS INDEX; PHYSICAL-ACTIVITY; UNITED-STATES; FETAL GROWTH;
   RISK-FACTORS; NEONATAL MACROSOMIA; SEDENTARY BEHAVIOR; METABOLIC
   SYNDROME; BRITISH CHILDREN; TEMPORAL TRENDS
AB Although the secular increase in pediatric obesity is well-documented, there has been no serious attempt to systematically address the causes of this secular trend. The aim of this paper is to provide a better understanding of the possible causes of the recent secular increase in pediatric obesity by reviewing and synthesizing the available literature pertaining to the topic. The paper addresses caveats and important considerations regarding the body mass index, physical activity, and diet and also considers alternative explanations (stress, sleep, maternal health, epigenetic mechanisms) for the secular trend. It is likely that the increased BMI is due to both an increased fat-free mass and fat mass (including waist circumference). Although total caloric intake has remained unchanged, there was a clear trend in increased simple sugar consumption. It is conceivable that total energy expenditure has decreased because of a decline in spontaneous but not voluntary physical activity. Several indicators of psycho-social stress (antidepressant medication prescriptions and suicide attempts, anxiety) have increased along with a decreased sleep duration. Finally, there is intriguing evidence that suggests that the secular trend is related to a common origin in fetal life that is exacerbated by postnatal events/stressors. The insight gained from examining the possible causes of the trend provides a better understanding of the basic etiology of pediatric obesity and should be incorporated into prevention and intervention models. (c) 2006 Elsevier Inc. All rights reserved.
C1 Iowa State Univ, Dept Hlth & Human Performance, Lab Study Growth Maturat & Phys Act, Ames, IA 50011 USA.
C3 Iowa State University
RP Eisenmann, JC (corresponding author), Iowa State Univ, Dept Hlth & Human Performance, Lab Study Growth Maturat & Phys Act, Ames, IA 50011 USA.
EM jce@iastate.edu
CR Agras WS, 2004, J PEDIATR-US, V145, P20, DOI 10.1016/j.jpeds.2004.03.023
   Ananth CV, 2002, SEMIN PERINATOL, V26, P260, DOI 10.1053/sper.2002.34772
   [Anonymous], 2017, Annex 3-03, P4
   Baeten JM, 2001, AM J PUBLIC HEALTH, V91, P436, DOI 10.2105/AJPH.91.3.436
   Bar-Or O., 1995, CHILD HLTH NUTR PHYS, P79
   BARKER DJP, 1992, BRIT J OBSTET GYNAEC, V99, P275, DOI 10.1111/j.1471-0528.1992.tb13719.x
   Bergmann RL, 2003, PAEDIATR PERINAT EP, V17, P244, DOI 10.1046/j.1365-3016.2003.00496.x
   Biddle SJH, 2004, J R SOC PROMO HEALTH, V124, P29, DOI 10.1177/146642400312400110
   Biddle SJH, 2004, J SPORT SCI, V22, P679, DOI 10.1080/02640410410001712412
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   BJORNTORP P, 1991, J INTERN MED, V230, P195
   Björntorp P, 2000, BRIT J NUTR, V83, pS49, DOI 10.1017/S0007114500000957
   Booth ML, 2003, AM J CLIN NUTR, V77, P29, DOI 10.1093/ajcn/77.1.29
   Catalano PM, 2003, J CLIN ENDOCR METAB, V88, P3505, DOI 10.1210/jc.2003-031046
   Catalano PM, 2003, AM J OBSTET GYNECOL, V189, P1698, DOI 10.1016/S0002-9378(03)00828-7
   Cavadini C, 2000, WESTERN J MED, V173, P378, DOI 10.1136/ewjm.173.6.378
   Chinn S, 2001, BRIT MED J, V322, P24, DOI 10.1136/bmj.322.7277.24
   Cole TJ, 2003, ECON HUM BIOL, V1, P161, DOI 10.1016/S1570-677X(02)00033-3
   Cooper AR, 2005, AM J PREV MED, V29, P179, DOI 10.1016/j.amepre.2005.05.009
   Dhurandhar NV, 2001, J NUTR, V131, p2794S, DOI 10.1093/jn/131.10.2794S
   Dietz WH, 2001, BRIT MED J, V322, P313, DOI 10.1136/bmj.322.7282.313
   Dyck RF, 2001, CAN J PUBLIC HEALTH, V92, P340, DOI 10.1007/BF03404975
   Ebbeling CB, 2004, JAMA-J AM MED ASSOC, V291, P2828, DOI 10.1001/jama.291.23.2828
   Ehrenberg HM, 2004, AM J OBSTET GYNECOL, V191, P964, DOI 10.1016/j.ajog.2004.05.052
   Ehrenberg HM, 2002, AM J OBSTET GYNECOL, V187, P1189, DOI 10.1067/mob.2002.127125
   Eisenmann J.C., 2004, J PHYS ACTIVITY HLTH, V1, P154, DOI 10.1123/jpah.1.2.154
   Eisenmann JC, 2004, OBES RES, V12, P1633, DOI 10.1038/oby.2004.203
   Eisenmann JC, 2003, AM J HUM BIOL, V15, P786, DOI 10.1002/ajhb.10214
   Eriksson J, 2001, INT J OBESITY, V25, P735, DOI 10.1038/sj.ijo.0801602
   Erlanson-Albertsson C, 2005, ACTA PAEDIATR, V94, P1523, DOI 10.1080/08035250500323780
   Ewald P., 2002, NEXT 50 YEARS, P289
   Ferrara A, 2004, OBSTET GYNECOL, V103, P526, DOI 10.1097/01.AOG.0000113623.18286.20
   Ford ES, 2004, PEDIATRICS, V114, P1534, DOI 10.1542/peds.2004-0674
   Freedman DS, 1997, PEDIATRICS, V99, P420, DOI 10.1542/peds.99.3.420
   French MA, 2003, AIDS, V17, P1977, DOI 10.1097/00002030-200309050-00017
   Gillman MW, 2003, PEDIATRICS, V111, DOI 10.1542/peds.111.3.e221
   Gupta NK, 2002, AM J HUM BIOL, V14, P762, DOI 10.1002/ajhb.10093
   Hediger ML, 1999, PEDIATRICS, V104, part. no., DOI 10.1542/peds.104.3.e33
   Iglowstein I, 2003, PEDIATRICS, V111, P302, DOI 10.1542/peds.111.2.302
   Jablonka E, 2004, INT J EPIDEMIOL, V33, P929, DOI 10.1093/ije/dyh231
   Janssens JP, 1999, EUR J CANCER PREV, V8, P289, DOI 10.1097/00008469-199908000-00004
   Johnson RK, 2000, P NUTR SOC, V59, P295, DOI 10.1017/S002966510000032X
   Kramer MS, 2002, J PEDIATR-US, V141, P538, DOI 10.1067/mpd.2002.128029
   KUCZMARSKI RJ, 1993, CRIT REV FOOD SCI, V33, P375, DOI 10.1080/10408399309527636
   LOCARD E, 1992, INT J OBESITY, V16, P721
   Maffeis C, 2000, EUR J PEDIATR, V159, pS35, DOI 10.1007/PL00014361
   Malina R., 1995, Physiological assessment of human fitness, P205
   Martin Joyce A, 2005, Natl Vital Stat Rep, V54, P1
   Maynard LM, 2001, PEDIATRICS, V107, P344, DOI 10.1542/peds.107.2.344
   McCarthy HD, 2005, INT J OBESITY, V29, P157, DOI 10.1038/sj.ijo.0802849
   McMillen IC, 2004, P NUTR SOC, V63, P405, DOI 10.1079/PNS2004370
   Merzouk H, 2000, BIOL NEONATE, V77, P17, DOI 10.1159/000014190
   Mindell JA, 1999, CHILD ADOL PSYCH CL, V8, P695
   Moreno LA, 2000, INT J OBESITY, V24, P925, DOI 10.1038/sj.ijo.0801255
   Moreno LA, 2005, ARCH DIS CHILD, V90, P818, DOI 10.1136/adc.2004.067066
   Moreno LA, 2001, PREV MED, V33, P357, DOI 10.1006/pmed.2001.0900
   Nicklas TA, 2001, AM J EPIDEMIOL, V153, P969, DOI 10.1093/aje/153.10.969
   Nielsen SJ, 2004, AM J PREV MED, V27, P205, DOI 10.1016/j.amepre.2004.05.005
   Ogden CL, 2002, JAMA-J AM MED ASSOC, V288, P1728, DOI 10.1001/jama.288.14.1728
   OH W, 1991, PEDIATR RES, V29, P606, DOI 10.1203/00006450-199106010-00016
   Oken E, 2003, OBES RES, V11, P496, DOI 10.1038/oby.2003.69
   Orskou J, 2001, ACTA OBSTET GYN SCAN, V80, P931
   Parikh SJ, 2003, AM J CLIN NUTR, V77, P281, DOI 10.1093/ajcn/77.2.281
   Parsons TJ, 2001, BRIT MED J, V323, P1331, DOI 10.1136/bmj.323.7325.1331
   Plagemann A, 1999, NEUROREPORT, V10, P3211, DOI 10.1097/00001756-199910190-00016
   Popper KarlR., 1988, REALISM AIM SCI
   Pratt M, 1999, MED SCI SPORT EXER, V31, pS526, DOI 10.1097/00005768-199911001-00007
   Putnam J., 2002, FoodReview, V25, P2
   Schmidt M, 2005, ARCH PEDIAT ADOL MED, V159, P626, DOI 10.1001/archpedi.159.7.626
   Sekine M, 2002, CHILD CARE HLTH DEV, V28, P163, DOI 10.1046/j.1365-2214.2002.00260.x
   Sekine Michikazu, 2002, J Epidemiol, V12, P33
   Siega-Riz AM, 2004, NUTR REV, V62, pS105, DOI 10.1111/j.1753-4887.2004.tb00079.x
   Sills MR, 2002, PEDIATRICS, V110, DOI 10.1542/peds.110.4.e40
   Sirard JR, 2005, MED SCI SPORT EXER, V37, P2062, DOI 10.1249/01.mss.0000179102.17183.6b
   Skidmore PML, 2004, QJM-INT J MED, V97, P817, DOI 10.1093/qjmed/hch136
   Slyper AH, 2004, J CLIN ENDOCR METAB, V89, P2540, DOI 10.1210/jc.2003-031449
   Spiegel K, 1999, LANCET, V354, P1435, DOI 10.1016/S0140-6736(99)01376-8
   Spiegel K, 2004, J CLIN ENDOCR METAB, V89, P5762, DOI 10.1210/jc.2004-1003
   Sturm R., 2005, Prev Chronic Dis, V2, P20
   Sturm Roland, 2005, Prev Chronic Dis, V2, pA20
   Surkan PJ, 2004, OBSTET GYNECOL, V104, P720, DOI 10.1097/01.AOG.0000141442.59573.cd
   Thompson AM, 2002, AM J HUM BIOL, V14, P669, DOI 10.1002/ajhb.10081
   Tremblay MS, 2002, INT J OBESITY, V26, P538, DOI 10.1038/sj.ijo.0801923
   Troiano RP, 2000, AM J CLIN NUTR, V72, p1343S, DOI 10.1093/ajcn/72.5.1343s
   Twenge JM, 2000, J PERS SOC PSYCHOL, V79, P1007, DOI 10.1037//0022-3514.79.6.1007
   Vickers MH, 2003, AM J PHYSIOL-REG I, V285, pR271, DOI 10.1152/ajpregu.00051.2003
   von Kries R, 2002, INT J OBESITY, V26, P710, DOI 10.1038/sj.ijo.0801980
   Wang YF, 2002, AM J CLIN NUTR, V75, P971, DOI 10.1093/ajcn/75.6.971
   Zemel MB, 2004, NUTR REV, V62, P125, DOI [10.1301/nr.2004.apr.125–131, 10.1111/j.1753-4887.2004.tb00034.x, 10.1301/nr.2004.apr.125-131]
   Zizza C, 2001, PREV MED, V32, P303, DOI 10.1006/pmed.2000.0817
NR 90
TC 68
Z9 82
U1 0
U2 15
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
EI 1096-0260
J9 PREV MED
JI Prev. Med.
PD MAY
PY 2006
VL 42
IS 5
BP 329
EP 335
DI 10.1016/j.ypmed.2006.02.002
PG 7
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 053GP
UT WOS:000238293900002
PM 16563483
DA 2025-06-11
ER

PT J
AU Qi, KJ
   Zhao, ZT
   Zhang, W
   Yang, F
AF Qi, Kai-Jie
   Zhao, Zhong-Tao
   Zhang, Wen
   Yang, Fang
TI The impacts of vitamin D supplementation in adults with metabolic
   syndrome: A systematic review and meta-analysis of randomized controlled
   trials
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE vitamin D; metabolic syndrome; randomized controlled trials;
   meta-analysis; inconclusive results
ID POLYCYSTIC-OVARY-SYNDROME; NONALCOHOLIC FATTY LIVER; D DEFICIENCY;
   BLOOD-PRESSURE; DOUBLE-BLIND; CARDIOVASCULAR-DISEASE; INSULIN
   SENSITIVITY; DIABETES-MELLITUS; OXIDATIVE STRESS; GLYCEMIC CONTROL
AB Background: Studies have shown the association of vitamin D status with the development of metabolic syndrome (MetS), which has attracted an extensive research interest with inconsistent results. Therefore, we hypothesized that vitamin D supplementation (VDS) will benefit adults with MetS.Aims: To test our hypothesis, we performed a meta-analysis to evaluate the effect of VDS on MetS in adults using relevant biomarkers such as anthropometric parameters, blood pressure, blood lipid profile, glycemia, oxidative stress and vitamin D toxicity (VDT).Methods: Randomized controlled trials published in PubMed, Web of Science, embase and the Cochrane Library between 2012 and 2022 on the effect of VDS on MetS in adults were searched. The language was limited to English. A meta-analysis performed using RevMan 5.4 and Stata 14.0 software, sensitivity analysis, and evaluation of the risk of bias and general quality of the resulting evidence were conducted.Results: Eventually, 13 articles were included in this meta-analysis. Overall, VDS significantly increased the endline serum 25-hydroxyvitamin D levels as compared to the control [MD:17.41, 95% CI (14.09, 20.73), p < 0.00001]. VDS did not affect waist circumference, body mass index, body fat percentage and VDT biomarkers, but decreased waist-to-hip ratio and blood pressure (p < 0.01). VDS significantly decreased fasting plasma glucose (FPG) [MD: 3.78; 95% CI (-6.52, -1.03), p = 0.007], but did not affect the levels of blood high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglyceride (TG). Pooled estimate of nine papers indicated a significant reduction of fasting insulin (FI) (p = 0.006), and homeostasis model assessment of insulin resistance (p = 0.0001). The quantitative insulin check index levels were moderately increased (p = 0.007) without any impact on the glycosylated hemoglobin type A1C (HbA1c). For the oxidative stress parameters, VDS significantly lowered the levels of malondialdehyde and hypersensitive C-reactive protein (p < 0.05).Conclusion: Results of this meta-analysis demonstrate that VDS only reduces insulin resistance and hypertension but not the blood lipid profile and HbA1c. It appears that the evidence for the benefit of VDS in adults with MetS is inconclusive. Further clinical studies are still needed.
C1 [Qi, Kai-Jie; Zhao, Zhong-Tao; Zhang, Wen; Yang, Fang] Hubei Univ Chinese Med, Sch Lab Med, Wuhan, Peoples R China.
C3 Hubei University of Chinese Medicine
RP Yang, F (corresponding author), Hubei Univ Chinese Med, Sch Lab Med, Wuhan, Peoples R China.
EM fangy521@hbtcm.edu.cn
RI Yang, Fang/JZT-6946-2024; Yang, Fang/J-8466-2017
OI Yang, Fang/0000-0002-7092-2532
FU Scientific Research Plan of Hubei Provincial Health Commission; 
   [WJ2021Q050]
FX Funding The work was supported by the Scientific Research Plan of Hubei
   Provincial Health Commission (Grant number: WJ2021Q050).
CR AlAnouti F, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113352
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Bovolini A, 2021, INT J SPORTS MED, V42, P199, DOI 10.1055/a-1263-0898
   Carr RM, 2016, GASTROENTEROL CLIN N, V45, P639, DOI 10.1016/j.gtc.2016.07.003
   Cashman KD, 2021, JBMR PLUS, V5, DOI 10.1002/jbm4.10547
   Castro-Barquero S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12102983
   Challoumas D, 2014, ATHEROSCLEROSIS, V235, P130, DOI 10.1016/j.atherosclerosis.2014.04.024
   Chandler PD, 2015, NUTR REV, V73, P577, DOI 10.1093/nutrit/nuv012
   Chang SW, 2019, PEDIATR NEONATOL, V60, P237, DOI 10.1016/j.pedneo.2019.04.007
   Charoenngam N, 2020, NUTRIENTS, V12, DOI 10.3390/nu12072097
   Chen C, 2019, NUTR J, V18, DOI 10.1186/s12937-019-0494-7
   Cojic M, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.610893
   Corcoy R, 2020, CLIN NUTR, V39, P976, DOI 10.1016/j.clnu.2019.04.006
   Cumpston M, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.ED000142
   Dudenkov DV, 2015, MAYO CLIN PROC, V90, P577, DOI 10.1016/j.mayocp.2015.02.012
   Ebadi SA, 2021, OBES RES CLIN PRACT, V15, P256, DOI 10.1016/j.orcp.2021.03.004
   Eslam M, 2020, J HEPATOL, V73, P202, DOI 10.1016/j.jhep.2020.03.039
   Fahed G, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23020786
   Farag HAM, 2019, DIABETES METAB SYND, V13, P1093, DOI 10.1016/j.dsx.2019.01.029
   Faraji S, 2020, J OBES METAB SYNDR, V29, P270, DOI 10.7570/jomes20003
   Farrokhian A, 2017, J NUTR, V147, P384, DOI 10.3945/jn.116.242008
   Ferreira PP, 2020, CLIMACTERIC, V23, P24, DOI [10.1007/s10111-019-00540-z, 10.1080/13697137.2019.1611761]
   Galior K, 2018, NUTRIENTS, V10, DOI 10.3390/nu10080953
   Ganji V, 2020, BIOFACTORS, V46, P180, DOI 10.1002/biof.1572
   Golzarand M, 2016, NUTR METAB CARDIOVAS, V26, P663, DOI 10.1016/j.numecd.2016.04.011
   Gramaglia C, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00621
   Grundy SM, 2006, CURR OPIN CARDIOL, V21, P1, DOI 10.1097/01.hco.0000200416.65370.a0
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Holick MF, 2015, MAYO CLIN PROC, V90, P561, DOI 10.1016/j.mayocp.2015.03.015
   Holick MF, 2011, J CLIN ENDOCR METAB, V96, P1911, DOI [10.1210/jc.2011-0385, 10.1210/jc.2011-1193]
   Hollis BW, 2013, J CLIN ENDOCR METAB, V98, P4619, DOI 10.1210/jc.2013-2653
   Hosseini SM, 2018, IRAN RED CRESCENT ME, V20, DOI 10.5812/ircmj.60746
   Hussin AM, 2017, EUR J NUTR, V56, P1095, DOI 10.1007/s00394-016-1159-3
   Imanparast F, 2020, APPL PHYSIOL NUTR ME, V45, P471, DOI 10.1139/apnm-2019-0113
   Javed Z, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010188
   Kamisnska S, 2020, INT J OCCUP MED ENV, V33, P107, DOI 10.13075/ijomeh.1896.01400
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Krul-Poel YHM, 2017, EUR J ENDOCRINOL, V176, pR1, DOI [10.1530/eje-16-0391, 10.1530/EJE-16-0391]
   Lagowska K, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111637
   Lemieux P, 2019, EUR J ENDOCRINOL, V181, P287, DOI 10.1530/EJE-19-0156
   Li XY, 2018, NUTRIENTS, V10, DOI 10.3390/nu10030375
   Lugg ST, 2015, DIS MARKERS, V2015, DOI 10.1155/2015/864370
   Mahmood SF, 2016, INT J VITAM NUTR RES, V86, P121, DOI 10.1024/0300-9831/a000426
   Makariou Stefania E, 2020, Arch Med Sci Atheroscler Dis, V5, pe64, DOI 10.5114/amsad.2020.95569
   Makariou SE, 2019, CLIN NUTR ESPEN, V29, P198, DOI 10.1016/j.clnesp.2018.10.004
   Maktabi M, 2017, HORM METAB RES, V49, P493, DOI 10.1055/s-0043-107242
   Mansouri M, 2018, DIABETES METAB SYND, V12, P393, DOI 10.1016/j.dsx.2018.01.007
   Mansournia MA, 2018, HORM METAB RES, V50, P429, DOI 10.1055/a-0630-1303
   Mansournia MA, 2017, EPIDEMIOLOGY, V28, P54, DOI 10.1097/EDE.0000000000000564
   Marcinowska-Suchowierska E, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00550
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   Mehri Z, 2019, ENDOCRINOL DIAB NUTR, V66, P628, DOI 10.1016/j.endinu.2019.02.006
   Melguizo-Rodríguez L, 2021, NUTRIENTS, V13, DOI 10.3390/nu13030830
   Mendes MM, 2020, P NUTR SOC, V79, P246, DOI 10.1017/S0029665119001538
   Misgar Raiz A, 2019, Indian J Endocrinol Metab, V23, P363, DOI 10.4103/ijem.IJEM_116_19
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Mora N, 2013, J Obes Weight Loss Ther, V3, P181
   Mukhopadhyay Pradip, 2019, Indian J Endocrinol Metab, V23, P215, DOI 10.4103/ijem.IJEM_59_19
   Mutt SJ, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061229
   Nakagawa S, 2017, BMC BIOL, V15, DOI 10.1186/s12915-017-0357-7
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Entrenas AO, 2017, OBES SURG, V27, P1222, DOI 10.1007/s11695-016-2445-0
   Ostadmohammadi V, 2019, CURR PHARM DESIGN, V25, P201, DOI 10.2174/1381612825666190308152943
   Ostman C, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-017-0590-y
   Pfotenhauer KM, 2017, J AM OSTEOPATH ASSOC, V117, P301, DOI 10.7556/jaoa.2017.055
   Piantanida E, 2017, ENDOCR CONNECT, V6, P943, DOI 10.1530/EC-17-0304
   Poolsup N, 2016, DIABETIC MED, V33, P290, DOI 10.1111/dme.12893
   Pragya P, 2021, J DIET SUPPL, V18, P630, DOI 10.1080/19390211.2020.1827116
   Rahimi-Ardabili H, 2013, J ENDOCRINOL INVEST, V36, P28, DOI 10.3275/8303
   Raja-Khan N, 2014, FERTIL STERIL, V101, P1740, DOI 10.1016/j.fertnstert.2014.02.021
   Raposo L, 2017, BMC ENDOCR DISORD, V17, DOI 10.1186/s12902-017-0221-3
   Ross AC, 2011, J AM DIET ASSOC, V111, P524, DOI 10.1016/j.jada.2011.01.004
   Sadiya A, 2016, CLIN NUTR, V35, P77, DOI 10.1016/j.clnu.2015.02.017
   Safarpour P, 2020, BMC FAM PRACT, V21, DOI 10.1186/s12875-020-1096-3
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Salekzamani S, 2016, J ENDOCRINOL INVEST, V39, P1303, DOI 10.1007/s40618-016-0507-8
   Scragg R, 2014, HYPERTENSION, V64, P725, DOI 10.1161/HYPERTENSIONAHA.114.03466
   Sharifi N, 2016, EXP BIOL MED, V241, P830, DOI 10.1177/1535370216629009
   Shidfar F, 2019, IRAN J PHARM RES, V18, P496
   Swart KMA, 2018, AM J CLIN NUTR, V107, P1043, DOI 10.1093/ajcn/nqy078
   Tabrizi R, 2018, HORM METAB RES, V50, DOI 10.1055/a-0651-4842
   Tamadon MR, 2018, HORM METAB RES, V50, P50, DOI 10.1055/s-0043-119221
   Tarantino G, 2020, J CLIN MED, V9, DOI 10.3390/jcm9010015
   Targher G, 2021, LANCET GASTROENTEROL, V6, pS78, DOI 10.1016/S2468-1253(21)00020-0
   Teixeira JS, 2018, NUTR HOSP, V35, P847, DOI 10.20960/nh.1657
   Theik NWY, 2021, CUREUS J MED SCIENCE, V13, DOI 10.7759/cureus.17419
   Tran V, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00148
   Turck D, 2017, EFSA J, V15, DOI 10.2903/j.efsa.2017.4780
   Vimaleswaran KS, 2014, LANCET DIABETES ENDO, V2, P719, DOI 10.1016/S2213-8587(14)70113-5
   Vimaleswaran KS, 2013, PLOS MED, V10, DOI 10.1371/journal.pmed.1001383
   Wang H, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-42
   Wang NJ, 2020, EUR J NUTR, V59, P1379, DOI 10.1007/s00394-019-01990-x
   Wongwiwatthananukit S, 2013, J ENDOCRINOL INVEST, V36, P558, DOI 10.3275/8817
   Xu YY, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000023672
   Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431
   Zhang YJ, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124464
   Zhao JF, 2021, ANN PALLIAT MED, V10, P169, DOI 10.21037/apm-20-2201
   Zheng JS, 2020, PLOS MED, V17, DOI 10.1371/journal.pmed.1003394
   Zhu W, 2018, DIABETES METAB SYND, V12, P727, DOI 10.1016/j.dsx.2018.04.010
   Zimmet P, 2005, J ATHEROSCLER THROMB, V12, P295, DOI 10.5551/jat.12.295
NR 101
TC 19
Z9 19
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD OCT 5
PY 2022
VL 13
AR 1033026
DI 10.3389/fphar.2022.1033026
PG 23
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 5Q9SM
UT WOS:000874162400001
PM 36278155
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rodriguez, JS
   Rodríguez-González, GL
   Reyes-Castro, LA
   Ibáñez, C
   Ramírez, A
   Chavira, R
   Larrea, F
   Nathanielsz, PW
   Zambrano, E
AF Rodriguez, J. S.
   Rodriguez-Gonzalez, G. L.
   Reyes-Castro, L. A.
   Ibanez, C.
   Ramirez, A.
   Chavira, R.
   Larrea, F.
   Nathanielsz, P. W.
   Zambrano, E.
TI Maternal obesity in the rat programs male offspring exploratory,
   learning and motivation behavior: prevention by dietary intervention
   pre-gestation or in gestation
SO INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
LA English
DT Article
DE Developmental programming; Cognition; Stress response; Consummatory
   behavior; Corticosterone
ID HIGH-FAT DIET; CHRONIC LUNG-DISEASE; LOW-PROTEIN DIET; JUNK FOOD DIET;
   PRESYNAPTIC TERMINALS; DEVELOPMENTAL ORIGINS; NUTRIENT RESTRICTION;
   METABOLIC SYNDROME; GENE-EXPRESSION; PRENATAL STRESS
AB We studied the effects of maternal high fat diet (HFD, 25% calories from fat administered before and during pregnancy and lactation) and dietary intervention (switching dams from HFD to control diet) at different periconceptional periods on male offspring anxiety related behavior, exploration, learning, and motivation. From weaning at postnatal day (PND) 21, female subjects produced to be the mothers in the study received either control diet (CTR - 5% calories from fat), HFD through pregnancy and lactation (MO), HFD during PNDs 21-90 followed by CTR diet (pre-gestation (PG) intervention) or HFD from PND 21 to 120 followed by CTR diet (gestation and lactation (G) intervention) and bred at PND 120. At 19 days of gestation maternal serum corticosterone was increased in MO and the PG and G dams showed partial recovery with intermediate levels. In offspring, no effects were found in the elevated plus maze test. In the open field test, MO and G offspring showed increase zone entries, displaying less thigmotaxis; PG offspring showed partial recuperation of this behavior. During initial operant conditioning MO. PG and G offspring displayed decreased approach behavior with subsequent learning impairment during the acquisition of FR-1 and FR-5 operant conditioning for sucrose reinforcement. Motivation during the progressive ratio test increased in MO offspring; PG and G intervention recuperated this behavior. We conclude that dietary intervention can reverse negative effects of maternal HFD and offspring outcomes are potentially due to elevated maternal corticosterone. (C) 2012 ISDN. Published by Elsevier Ltd. All rights reserved.
C1 [Rodriguez-Gonzalez, G. L.; Reyes-Castro, L. A.; Ibanez, C.; Ramirez, A.; Chavira, R.; Larrea, F.; Zambrano, E.] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Mexico City 14000, DF, Mexico.
   [Rodriguez, J. S.; Nathanielsz, P. W.] Univ Texas Hlth Sci Ctr San Antonio, Dept Obstet & Gynecol, Ctr Pregnancy & Newborn Res, San Antonio, TX 78229 USA.
C3 Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico; University of Texas System; University of Texas Health Science
   Center at San Antonio
RP Zambrano, E (corresponding author), Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Mexico City 14000, DF, Mexico.
EM zamgon@unam.mx
RI Larrea, Fernando/AAC-1900-2021; Rodríguez-González,
   Guadalupe/AAB-1291-2021; Ibanez Chavez, Carlos Alberto/AAG-2398-2020;
   REYES CASTRO, LUIS ANTONIO/E-9896-2019
OI Rodriguez Gonzalez, Guadalupe Leticia/0000-0002-3267-4793; Zambrano,
   Elena/0000-0002-0362-9117; Nathanielsz, Peter/0000-0001-8410-6280;
   Ibanez Chavez, Carlos Alberto/0000-0002-3435-497X; REYES CASTRO, LUIS
   ANTONIO/0000-0003-0397-6810
FU Consejo Nacional de Ciencias y Tecnologia (CONACyT), Mexico [155166];
   NIH [HD 21350]; CONACyT
FX L.A. Reyes-Castro and G.L. Rodriguez-Gonzalez are graduate students from
   Doctorado en Ciencias Biomedicas, Facultad de Medicina, Universidad
   Nacional Autonoma de Mexico and are recipients of CONACyT fellowship.
   This work was supported by Consejo Nacional de Ciencias y Tecnologia
   (CONACyT 155166), Mexico and NIH HD 21350.
CR Antonow-Schlorke I, 2003, J PHYSIOL-LONDON, V547, P117, DOI 10.1113/jphysiol.2002.025700
   Antonow-Schlorke I, 2001, NEUROSCI LETT, V297, P147, DOI 10.1016/S0304-3940(00)01605-0
   Armitage JA, 2004, J PHYSIOL-LONDON, V561, P355, DOI 10.1113/jphysiol.2004.072009
   Bautista CJ, 2008, PEDIATR RES, V63, P358, DOI 10.1203/01.pdr.0000304938.78998.21
   Bayol SA, 2008, J PHYSIOL-LONDON, V586, P3219, DOI 10.1113/jphysiol.2008.153817
   Bayol SA, 2010, ENDOCRINOLOGY, V151, P1451, DOI 10.1210/en.2009-1192
   Bilbo SD, 2010, FASEB J, V24, P2104, DOI 10.1096/fj.09-144014
   Bouret SG, 2010, J NUTR, V140, P653, DOI 10.3945/jn.109.112433
   Bouret SG, 2010, FORUM NUTR, V63, P84, DOI 10.1159/000264396
   Chang GQ, 2008, J NEUROSCI, V28, P12107, DOI 10.1523/JNEUROSCI.2642-08.2008
   Cottrell EC, 2009, FRONT BEHAV NEUROSCI, V3, DOI 10.3389/neuro.08.019.2009
   Dabelea D, 2007, DIABETES CARE, V30, pS169, DOI 10.2337/dc07-s211
   Desai M, 2007, AM J PHYSIOL-REG I, V293, pR2306, DOI 10.1152/ajpregu.00783.2006
   French NP, 2004, AM J OBSTET GYNECOL, V190, P588, DOI 10.1016/j.ajog.2003.12.016
   Guzmán C, 2006, J PHYSIOL-LONDON, V572, P97, DOI 10.1113/jphysiol.2005.103903
   Han HC, 2004, J PHYSIOL-LONDON, V558, P111, DOI 10.1113/jphysiol.2004.061697
   Hyatt MA, 2011, REPRODUCTION, V141, P119, DOI 10.1530/REP-10-0325
   JOHNSON JWC, 1981, AM J OBSTET GYNECOL, V141, P1053
   Kapoor A, 2008, BRAIN RES REV, V57, P586, DOI 10.1016/j.brainresrev.2007.06.013
   Karemaker R, 2008, PEDIATRICS, V121, pE870, DOI 10.1542/peds.2007-2454
   Karemaker R, 2006, PEDIATR RES, V60, P745, DOI 10.1203/01.pdr.0000246200.76860.de
   King JC, 2006, ANNU REV NUTR, V26, P271, DOI 10.1146/annurev.nutr.24.012003.132249
   Langley-Evans SC, 2009, J ANAT, V215, P36, DOI 10.1111/j.1469-7580.2008.00977.x
   Lima ND, 2011, BRIT J NUTR, V105, P1405, DOI 10.1017/S0007114510005064
   Matthews S G, 2001, Semin Neonatol, V6, P309, DOI 10.1053/siny.2001.0066
   Meyer-Bahlburg HFL, 2011, ENDOCR DEV, V20, P88, DOI 10.1159/000321225
   Naef L, 2011, NEUROSCIENCE, V176, P225, DOI 10.1016/j.neuroscience.2010.12.037
   Naef L, 2008, PSYCHOPHARMACOLOGY, V197, P83, DOI 10.1007/s00213-007-1008-4
   Naef L, 2007, ENDOCRINOLOGY, V148, P5977, DOI 10.1210/en.2007-0442
   Nijland MJ, 2008, CURR OPIN OBSTET GYN, V20, P132, DOI 10.1097/GCO.0b013e3282f76753
   Nuyt AM, 2009, CURR OPIN NEPHROL HY, V18, P144, DOI 10.1097/MNH.0b013e328326092c
   Puts DA, 2008, ARCH SEX BEHAV, V37, P100, DOI 10.1007/s10508-007-9271-3
   Ramos A, 2008, TRENDS PHARMACOL SCI, V29, P493, DOI 10.1016/j.tips.2008.07.005
   Ramos A, 2008, BEHAV BRAIN RES, V193, P277, DOI 10.1016/j.bbr.2008.06.007
   Reyes-Castro LA, 2012, BEHAV BRAIN RES, V227, P324, DOI 10.1016/j.bbr.2011.06.008
   Reyes-Castro LA, 2012, INT J DEV NEUROSCI, V30, P39, DOI 10.1016/j.ijdevneu.2011.10.002
   Reyes-Castro LA, 2011, INT J DEV NEUROSCI, V29, P177, DOI 10.1016/j.ijdevneu.2010.11.002
   Rodriguez A, 2010, J CHILD PSYCHOL PSYC, V51, P134, DOI 10.1111/j.1469-7610.2009.02133.x
   Rodriguez JS, 2011, AM J OBSTET GYNECOL, V204, DOI 10.1016/j.ajog.2011.01.063
   Sébert SP, 2010, REPRODUCTION, V139, P265, DOI 10.1530/REP-09-0173
   Sébert SP, 2009, ENDOCRINOLOGY, V150, P634, DOI 10.1210/en.2008-0542
   Seckl JR, 2007, PROG BRAIN RES, V167, P17, DOI 10.1016/S0079-6123(07)67002-2
   Solomons NW, 2009, NUTR REV, V67, pS12, DOI 10.1111/j.1753-4887.2009.00152.x
   Spencer SJ, 2009, PSYCHONEUROENDOCRINO, V34, P1133, DOI 10.1016/j.psyneuen.2009.02.013
   Sullivan EL, 2011, NEUROENDOCRINOLOGY, V93, P1, DOI 10.1159/000322038
   Sullivan EL, 2010, J NEUROSCI, V30, P3826, DOI 10.1523/JNEUROSCI.5560-09.2010
   Symonds ME, 2009, NAT REV ENDOCRINOL, V5, P604, DOI 10.1038/nrendo.2009.195
   Szuran TF, 2000, PHYSIOL BEHAV, V71, P353, DOI 10.1016/S0031-9384(00)00351-6
   Taylor PD, 2007, EXP PHYSIOL, V92, P287, DOI 10.1113/expphysiol.2005.032854
   Torres N, 2010, AM J PHYSIOL-ENDOC M, V298, pE270, DOI 10.1152/ajpendo.00437.2009
   Tozuka Y, 2010, NEUROCHEM INT, V57, P235, DOI 10.1016/j.neuint.2010.05.015
   Tozuka Y, 2009, FASEB J, V23, P1920, DOI 10.1096/fj.08-124784
   TRULLAS R, 1993, PSYCHOPHARMACOLOGY, V111, P323, DOI 10.1007/BF02244948
   Tsoi E, 2010, POSTGRAD MED J, V86, P617, DOI 10.1136/pgmj.2010.098186
   UNO H, 1990, DEV BRAIN RES, V53, P157, DOI 10.1016/0165-3806(90)90002-G
   UNO H, 1994, HORM BEHAV, V28, P336, DOI 10.1006/hbeh.1994.1030
   Vendruscolo L.F., 2003, PSYCHOPHARMACOLOGY B, V170, P287
   Vucetic Z, 2010, ENDOCRINOLOGY, V151, P4756, DOI 10.1210/en.2010-0505
   Wadhwa PD, 2009, SEMIN REPROD MED, V27, P358, DOI 10.1055/s-0029-1237424
   Walker CD, 2008, ANN NY ACAD SCI, V1144, P189, DOI 10.1196/annals.1418.023
   Warner MJ, 2010, BIOCHEM J, V427, P333, DOI 10.1042/BJ20091861
   Weinstock M, 2008, NEUROSCI BIOBEHAV R, V32, P1073, DOI 10.1016/j.neubiorev.2008.03.002
   Wright T, 2011, PHYSIOL BEHAV, V103, P164, DOI 10.1016/j.physbeh.2011.01.008
   Zambrano E, 2006, J PHYSIOL-LONDON, V571, P221, DOI 10.1113/jphysiol.2005.100313
   Zambrano E, 2005, J PHYSIOL-LONDON, V566, P225, DOI 10.1113/jphysiol.2005.086462
   Zambrano E, 2005, J PHYSIOL-LONDON, V563, P275, DOI 10.1113/jphysiol.2004.078543
   Zambrano E, 2010, J PHYSIOL-LONDON, V588, P1791, DOI 10.1113/jphysiol.2010.190033
NR 67
TC 62
Z9 68
U1 0
U2 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0736-5748
EI 1873-474X
J9 INT J DEV NEUROSCI
JI Int. J. Dev. Neurosci.
PD APR
PY 2012
VL 30
IS 2
BP 75
EP 81
DI 10.1016/j.ijdevneu.2011.12.012
PG 7
WC Developmental Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology; Neurosciences & Neurology
GA 916ND
UT WOS:000302109600003
PM 22239918
DA 2025-06-11
ER

PT J
AU Chaudhuri, A
   Watson, WS
   Pearn, J
   Behan, PO
AF Chaudhuri, A
   Watson, WS
   Pearn, J
   Behan, PO
TI The symptoms of chronic fatigue syndrome are related to abnormal ion
   channel function
SO MEDICAL HYPOTHESES
LA English
DT Article
ID FAMILIAL HEMIPLEGIC MIGRAINE; CALCIUM CHANNELS; SKELETAL-MUSCLE;
   SYNDROME-X; MECHANISMS; RECEPTORS; SCLEROSIS; RESPONSES; EXERCISE;
   SEIZURES
AB The pathogenesis of chronic fatigue syndrome (CFS) is unknown but one of the most characteristic features of the illness is fluctuation in symptoms which can be induced by physical and/or mental stress. Other conditions in which fluctuating fatigue occurs are caused by abnormal ion channels in the cell membrane. These include genetically determined channelopathies, e.g. hypokalemic periodic paralysis, episodic ataxia type 2 and acquired conditions such as neuromyotonia, myasthenic syndromes, multiple sclerosis and inflammatory demyelinating polyneuropathies. Our hypothesis is that abnormal ion channel function underlies the symptoms of CFS and this is supported also by the finding of abnormal cardiac-thallium(201) SPECT scans in CFS, similar to that found in syndrome X, another disorder of ion channels. CFS and syndrome X can have identical clinical symptoms. CFS may begin after exposure to specific toxins which are known to produce abnormal sodium ion channels. Finally, in CFS, increased resting energy expenditure (REE) occurs, a state influenced by transmembrane ion transport. The hypothesis that ion channels are abnormal in CFS may help to explain the fluctuating fatigue and other symptoms. (C) 2000 Harcourt Publishers Ltd.
C1 So Gen Hosp, Dept Nucl Med, Glasgow G51 4TF, Lanark, Scotland.
   Inst Neurol Sci, Univ Dept Neurol, Glasgow G51 4TF, Lanark, Scotland.
   Univ Queensland, Dept Child Hlth, Brisbane, Qld, Australia.
C3 University of Glasgow; University of Glasgow; University of Queensland
RP So Gen Hosp, Inst Neurol Sci, Univ Dept Neurol, 1345 Govan Rd, Glasgow G51 4TF, Lanark, Scotland.
EM osslv@clinmed.gla.ac.uk
OI Pearn, John/0000-0002-8815-2994
CR Ackerman MJ, 1997, NEW ENGL J MED, V336, P1575, DOI 10.1056/NEJM199705293362207
   ARNOLD DL, 1984, LANCET, V1, P1367
   BAKHEIT AMO, 1992, BRIT MED J, V304, P1010, DOI 10.1136/bmj.304.6833.1010
   BARNES PRJ, 1993, J NEUROL NEUROSUR PS, V56, P679, DOI 10.1136/jnnp.56.6.679
   BEHAN PO, 1988, CRIT REV NEUROBIOL, V4, P157
   BENOIT E, 1996, TOXICON, V31, P1121
   BEVER CT, 1994, ANN NEUROL, V36, pS118, DOI 10.1002/ana.410360728
   BIDARD JN, 1984, J BIOL CHEM, V259, P8353
   Bloomquist JR, 1996, ANNU REV ENTOMOL, V41, P163, DOI 10.1146/annurev.en.41.010196.001115
   BOGHEN D, 1993, EUR NEUROL, V33, P199, DOI 10.1159/000116936
   BOUDOULAS H, 1974, AM J CARDIOL, V34, P501, DOI 10.1016/0002-9149(74)90118-0
   BOUHOLAIGAH I, 1995, JAMA-J AM MED ASSOC, V274, P961, DOI 10.1001/jama.274.12.961
   BRUNO RL, 1995, ANN NY ACAD SCI, V753, P257, DOI 10.1111/j.1749-6632.1995.tb27552.x
   Burgess DL, 1997, CELL, V88, P385, DOI 10.1016/S0092-8674(00)81877-2
   CAMERON J, 1993, J TOXICOL-CLIN TOXIC, V31, P571, DOI 10.3109/15563659309025762
   CARRASCO L, 1993, NATO ADV SCI INST SE, V240, P283
   Chaudhuri A., 1997, Journal of the Neurological Sciences, V150, pS225, DOI 10.1016/S0022-510X(97)85970-9
   CHAUDHURI A, 1998, IN PRESS AM J MED
   CHAUDHURI A, 1998, IN PRESS P ROYAL COL
   CLEARE AJ, 1995, J AFFECT DISORDERS, V34, P283, DOI 10.1016/0165-0327(95)00026-J
   CREA F, 1997, SYNDR X SUMM, P48
   Critchley EMR, 1996, LANCET, V347, P1561, DOI 10.1016/S0140-6736(96)90717-5
   DUNSTAN RH, 1995, MED J AUSTRALIA, V163, P293
   ENGSTROM I, 1993, CLIN CHIM ACTA, V219, P113, DOI 10.1016/0009-8981(93)90202-F
   GARRY RF, 1991, AIDS, V5, P1381, DOI 10.1097/00002030-199111000-00017
   GOW JW, 1994, INT M CHRON FAT SYND
   Greenberg DA, 1997, ANN NEUROL, V42, P275, DOI 10.1002/ana.410420302
   GRIGGS RC, 1995, ANN NEUROL, V37, P285, DOI 10.1002/ana.410370302
   Harper PeterS., 1979, MYOTONIC DYSTROPHY
   Hilton PJ, 1996, LANCET, V348, P303, DOI 10.1016/S0140-6736(96)02257-X
   HINSON JP, 1995, J ENDOCRINOL, V146, P369, DOI 10.1677/joe.0.1460369
   KAGAN BL, 1992, SCIENCE, V255, P1427, DOI 10.1126/science.1371890
   KIM YI, 1988, SCIENCE, V239, P405, DOI 10.1126/science.2447652
   Krupp LB, 1996, CURR OPIN NEUROL, V9, P456, DOI 10.1097/00019052-199612000-00011
   LANE RJM, 1995, BRIT MED J, V311, P544, DOI 10.1136/bmj.311.7004.544
   LINDE A, 1992, J INFECT DIS, V165, P994, DOI 10.1093/infdis/165.6.994
   LIPTON SA, 1991, ANN NEUROL, V30, P110, DOI 10.1002/ana.410300121
   Majeed T., 1995, EOS-Rivista di Immunologia ed Immunofarmacologia, V15, P8
   MAY A, 1995, HUM GENET, V96, P604, DOI 10.1007/BF00197420
   McClave S A, 1992, Nutr Clin Pract, V7, P207, DOI 10.1177/0115426592007005207
   Mesch U, 1996, LANCET, V347, P1193, DOI 10.1016/S0140-6736(96)90655-8
   MYGLAND A, 1992, ANN NEUROL, V32, P589, DOI 10.1002/ana.410320419
   NEWSOMDAVIS J, 1993, BRAIN, V116, P453, DOI 10.1093/brain/116.2.453
   NODGREN B, 1997, MUSCLE NERVE, V20, P1341
   Patterson J., 1995, EOS-Rivista di Immunologia ed Immunofarmacologia, V15, P53
   Pearn J., 1995, EOS-Rivista di Immunologia ed Immunofarmacologia, V15, P63
   Pearn J., 1996, J CHRONIC FATIGUE SY, V2, P29, DOI [10.1300/J092v02n02_03, DOI 10.1300/J092V02N02_03]
   Pearn JH, 1997, MED J AUSTRALIA, V166, P309, DOI 10.5694/j.1326-5377.1997.tb122320.x
   PRIVITERA MD, 1994, NEUROLOGY, V44, P1453, DOI 10.1212/WNL.44.8.1453
   SCOTT L, 1998, THESIS U LONDON
   SMITH RG, 1992, NEW ENGL J MED, V327, P1721, DOI 10.1056/NEJM199212103272405
   SONODA Y, 1994, MUSCLE NERVE, V17, P891, DOI 10.1002/mus.880170808
   SOUSSI B, 1993, LANCET, V341, P829, DOI 10.1016/0140-6736(93)90605-G
   Talbott JH, 1941, MEDICINE, V20, P85, DOI 10.1097/00005792-194102000-00002
   UNCINI A, 1995, J NEUROL SCI, V129, P214, DOI 10.1016/0022-510X(94)00283-T
   Vernoux JP, 1997, TOXICON, V35, P889, DOI 10.1016/S0041-0101(96)00191-2
   Voss TG, 1996, J VIROL, V70, P5447, DOI 10.1128/JVI.70.8.5447-5454.1996
   WALDENSTROM A, 1992, J INTERN MED, V231, P327, DOI 10.1111/j.1365-2796.1992.tb00940.x
   WALDENSTROM A, 1993, SCAND J INFECT DIS, P131
   Watson W. S., 1997, J CHRONIC FATIGUE SY, V3, P1, DOI [DOI 10.1300/J092V03N03_01, 10.1300/J092v03n03_01]
   WAXMAN SG, 1995, ANN NEUROL
   Weidmann B, 1997, AM J CARDIOL, V79, P959, DOI 10.1016/S0002-9149(97)00020-9
NR 62
TC 25
Z9 25
U1 0
U2 3
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD JAN
PY 2000
VL 54
IS 1
BP 59
EP 63
DI 10.1054/mehy.1998.0822
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 295PL
UT WOS:000085977000010
PM 10790725
DA 2025-06-11
ER

PT J
AU Rodrigues, DM
   Reis, RS
   Molle, RD
   Machado, TD
   Mucellini, AB
   Bortoluzzi, A
   Toazza, R
   Pérez, JA
   Salum, GA
   Agranonik, M
   Minuzzi, L
   Levitan, RD
   Buchweitz, A
   Franco, AR
   Manfro, GG
   Silveira, PP
AF Rodrigues, Danitsa Marcos
   Reis, Roberta Sena
   Molle, Roberta Dalle
   Machado, Tania Diniz
   Mucellini, Amanda Brondani
   Bortoluzzi, Andressa
   Toazza, Rudineia
   Perez, Juliano Adams
   Salum, Giovanni Abrahao
   Agranonik, Marilyn
   Minuzzi, Luciano
   Levitan, Robert D.
   Buchweitz, Augusto
   Franco, Alexandre Rosa
   Manfro, Gisele Gus
   Silveira, Patricia Pelufo
TI Decreased comfort food intake and allostatic load in adolescents
   carrying the A3669G variant of the glucocorticoid receptor gene
SO APPETITE
LA English
DT Article
DE Glucocorticoid receptor gene polymorphism; Feeding behaviour; Comfort
   food; Reward circuitry; Insulin
ID PITUITARY-ADRENAL AXIS; STRIATAL DOPAMINE RELEASE; IN-VIVO; PSYCHOSOCIAL
   STRESS; POLYMORPHISM A3669G; ABDOMINAL OBESITY; BIPOLAR DISORDER;
   SELF-MEDICATION; MESSENGER-RNA; BETA-ISOFORM
AB Background: The A3669G single nucleotide polymorphism (SNP) of the glucocorticoid receptor (GR) gene NR3C1 is associated with altered tissue sensitivity to glucocorticoids (GCs). GCs modulate the food reward circuitry and are implicated in increased intake of palatable foods, which can lead to the metabolic syndrome and obesity. We hypothesized that presence of the G variant of the A3669G SNP would affect preferences for palatable foods and alter metabolic, behavioural, and neural outcomes.
   Methods: One hundred thirty-one adolescents were genotyped for the A3669G polymorphism, underwent anthropometric assessment and nutritional evaluations, and completed behavioural measures. A subsample of 74 subjects was followed for 5 years and performed a brain functional magnetic resonance imaging (fMRI) paradigm to verify brain activity in response to food cues.
   Results: Sugar and total energy consumption were lower in A3669G G allele variant carriers. On followup, this group also had reduced serum insulin concentrations, increased insulin sensitivity, and lower anxiety scores. Because of our unbalanced sample sizes (31/37 participants non-G allele carriers/total), our imaging data analysis failed to find whole brain-corrected significant results in between-group t-tests.
   Conclusion: These results highlight that a genetic variation in the GR gene is associated, at the cellular level, with significant reduction in GC sensitivity, which, at cognitive and behavioural levels, translates to altered food intake and emotional stress response. This genetic variant might play a major role in decreasing risk for metabolic and psychiatric diseases. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Rodrigues, Danitsa Marcos; Bortoluzzi, Andressa; Toazza, Rudineia; Manfro, Gisele Gus; Silveira, Patricia Pelufo] Univ Fed Rio Grande do Sul, Grad Program Neurosci, Porto Alegre, RS, Brazil.
   [Rodrigues, Danitsa Marcos; Mucellini, Amanda Brondani; Bortoluzzi, Andressa; Toazza, Rudineia; Salum, Giovanni Abrahao; Manfro, Gisele Gus] Univ Fed Rio Grande do Sul, Anxiety Disorders Program Child & Adolescent Psyc, Porto Alegre, RS, Brazil.
   [Reis, Roberta Sena; Molle, Roberta Dalle; Machado, Tania Diniz] Univ Fed Rio Grande do Sul, Grad Program Child & Adolescent Hlth, Porto Alegre, RS, Brazil.
   [Mucellini, Amanda Brondani; Salum, Giovanni Abrahao; Manfro, Gisele Gus] Univ Fed Rio Grande do Sul, Grad Program Psychiat & Behav Sci, Porto Alegre, RS, Brazil.
   [Perez, Juliano Adams] HCPA, Computed Tomog & Magnet Resonance Unit, Porto Alegre, RS, Brazil.
   [Agranonik, Marilyn] Fundacao Econ & Estat, Stat Informat Ctr, Porto Alegre, RS, Brazil.
   [Minuzzi, Luciano] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada.
   [Buchweitz, Augusto; Franco, Alexandre Rosa] Pontificia Univ Catolica Rio Grande do Sul, Brain Inst Rio Grande do Sul InsCer, Porto Alegre, RS, Brazil.
   [Silveira, Patricia Pelufo] McGill Univ, Dept Psychiat, Montreal, PQ, Canada.
   [Levitan, Robert D.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
C3 Universidade Federal do Rio Grande do Sul; Universidade Federal do Rio
   Grande do Sul; Universidade Federal do Rio Grande do Sul; Universidade
   Federal do Rio Grande do Sul; McMaster University; Pontificia
   Universidade Catolica Do Rio Grande Do Sul; McGill University;
   University of Toronto
RP Rodrigues, DM (corresponding author), Hosp Clin Porto Alegre, Ramiro Barcelos 2350, BR-90035003 Porto Alegre, RS, Brazil.
EM danitsarodrigues@gmail.com
RI Silveira, Patricia/A-7139-2011; Machado, Tania/AAQ-1446-2020; Minuzzi,
   Luciano/ABH-3481-2020; Manfro, Gisele/B-7020-2009; Franco,
   Alexandre/D-1706-2015; Agranonik, Marilyn/B-8416-2015; Brondani
   Mucellini, Amanda/C-7248-2015; Salum, Giovanni/A-7849-2010; Silveira,
   Patricia/F-4897-2014; Buchweitz, Augusto/G-3829-2012
OI Agranonik, Marilyn/0000-0003-2699-9628; Brondani Mucellini,
   Amanda/0000-0002-8707-8585; Machado, Tania/0000-0002-3706-4185; Salum,
   Giovanni/0000-0002-7537-7289; Silveira, Patricia/0000-0001-8626-2519;
   Buchweitz, Augusto/0000-0003-3791-7472
FU Brazilian National Council for Technological and Scientific Development
   (CNPq) Brazil [478820/2010]; Coordination for the Improvement of Higher
   Education Personnel (CAPES) [3024/2010]; Fundo de Incentivo a Pesquisa e
   Eventos do Hospital de Clinicas de Porto Alegre (FIPE/HCPA) [12-0254]
FX Brazilian National Council for Technological and Scientific Development
   (CNPq) Brazil 2010 (PPS, 478820/2010), Coordination for the Improvement
   of Higher Education Personnel (CAPES) number 3024/2010 and Fundo de
   Incentivo a Pesquisa e Eventos do Hospital de Clinicas de Porto Alegre
   (FIPE/HCPA), project number 12-0254.
CR Adam TC, 2007, PHYSIOL BEHAV, V91, P449, DOI 10.1016/j.physbeh.2007.04.011
   American Psychological Association, 2013, AR TEENS AD AD STRES
   Ashburner J, 1997, NEUROIMAGE, V6, P209, DOI 10.1006/nimg.1997.0290
   Ashburner J, 2005, NEUROIMAGE, V26, P839, DOI 10.1016/j.neuroimage.2005.02.018
   Baik JH, 2013, BMB REP, V46, P519, DOI 10.5483/BMBRep.2013.46.11.207
   Berridge KC, 1996, NEUROSCI BIOBEHAV R, V20, P1, DOI 10.1016/0149-7634(95)00033-B
   Birmaher B, 1997, J AM ACAD CHILD PSY, V36, P545, DOI 10.1097/00004583-199704000-00018
   Briassoulis G, 2011, ENDOCR PRACT, V17, P941, DOI 10.4158/EP11061.RA
   Charmandari E, 2010, EUR J CLIN INVEST, V40, P932, DOI 10.1111/j.1365-2362.2010.02336.x
   Chriguer RS, 2012, J CLIN IMMUNOL, V32, P786, DOI 10.1007/s10875-012-9679-y
   Chriguer RS, 2005, J CLIN ENDOCR METAB, V90, P5978, DOI 10.1210/jc.2005-0067
   Dallman MF, 2010, TRENDS ENDOCRIN MET, V21, P159, DOI 10.1016/j.tem.2009.10.004
   Dallman MF, 2005, BRAIN BEHAV IMMUN, V19, P275, DOI 10.1016/j.bbi.2004.11.004
   De Antonio SR, 2002, J RHEUMATOL, V29, P46
   de Carvalho AP, 2004, KIDNEY INT, V65, P403, DOI 10.1111/j.1523-1755.2004.00392.x
   de Kloet E Ronald, 2003, Endocr Regul, V37, P51
   Derijk RH, 2001, J RHEUMATOL, V28, P2383
   Epel E, 2001, PSYCHONEUROENDOCRINO, V26, P37, DOI 10.1016/S0306-4530(00)00035-4
   Figlewicz DP, 2009, AM J PHYSIOL-REG I, V296, pR9, DOI 10.1152/ajpregu.90725.2008
   Friston KJ, 1996, MAGNET RESON MED, V35, P346, DOI 10.1002/mrm.1910350312
   GREENO CG, 1994, PSYCHOL BULL, V115, P444, DOI 10.1037/0033-2909.115.3.444
   Hargrave SL, 2016, CURR OPIN BEHAV SCI, V9, P40, DOI 10.1016/j.cobeha.2015.12.001
   He B, 2016, MOL CELL BIOL, V36, P714, DOI 10.1128/MCB.00908-15
   Henn RL, 2010, CAD SAUDE PUBLICA, V26, P2068, DOI 10.1590/S0102-311X2010001100008
   Hinds TD, 2010, MOL ENDOCRINOL, V24, P1715, DOI 10.1210/me.2009-0411
   HOLLENBERG SM, 1985, NATURE, V318, P635, DOI 10.1038/318635a0
   Huizenga NATM, 1998, J CLIN ENDOCR METAB, V83, P47, DOI 10.1210/jc.83.1.47
   Huizenga NATM, 1998, J CLIN ENDOCR METAB, V83, P144, DOI 10.1210/jc.83.1.144
   Isolan L, 2011, J ANXIETY DISORD, V25, P741, DOI 10.1016/j.janxdis.2011.03.015
   John K, 2016, AM J PHYSIOL-ENDOC M, V310, pE249, DOI 10.1152/ajpendo.00478.2015
   Kino T, 2009, BIOCHEM BIOPH RES CO, V381, P671, DOI 10.1016/j.bbrc.2009.02.110
   Kumsta R, 2007, BIOL PSYCHIAT, V62, P863, DOI 10.1016/j.biopsych.2007.04.013
   Kurokawa K, 2011, STRESS, V14, P431, DOI 10.3109/10253890.2011.555930
   Lang P., 2008, A8 U FLOR NAT I MENT
   Marino JS, 2016, J BIOL CHEM, V291, P25776, DOI 10.1074/jbc.M116.752311
   Mikl M, 2008, MAGN RESON IMAGING, V26, P490, DOI 10.1016/j.mri.2007.08.006
   Moraitis AG, 2017, J STEROID BIOCHEM, V165, P114, DOI 10.1016/j.jsbmb.2016.03.023
   MORLEY JE, 1983, LIFE SCI, V32, P2169
   Müller MB, 2003, NAT NEUROSCI, V6, P1100, DOI 10.1038/nn1123
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Oakley RH, 1996, J BIOL CHEM, V271, P9550, DOI 10.1074/jbc.271.16.9550
   Oswald LM, 2005, NEUROPSYCHOPHARMACOL, V30, P821, DOI 10.1038/sj.npp.1300667
   Page KA, 2011, J CLIN INVEST, V121, P4161, DOI 10.1172/JCI57873
   Panarelli M, 1998, J CLIN ENDOCR METAB, V83, P1846, DOI 10.1210/jc.83.6.1846
   Pecoraro N, 2004, ENDOCRINOLOGY, V145, P3754, DOI 10.1210/en.2004-0305
   Pecoraro N, 2006, PROG NEUROBIOL, V79, P247, DOI 10.1016/j.pneurobio.2006.07.004
   Ramamoorthy S, 2016, RHEUM DIS CLIN N AM, V42, P15, DOI 10.1016/j.rdc.2015.08.002
   Rovaris DL, 2013, J NEURAL TRANSM, V120, P1499, DOI 10.1007/s00702-013-1012-2
   Salum GA, 2011, REV BRAS PSIQUIATR, V33, P181, DOI 10.1590/S1516-44462011000200015
   Schaaf MJM, 2002, STEROIDS, V67, P627, DOI 10.1016/S0039-128X(02)00015-6
   Sinha R, 2008, ANN NY ACAD SCI, V1141, P105, DOI 10.1196/annals.1441.030
   Sladky R, 2011, NEUROIMAGE, V58, P588, DOI 10.1016/j.neuroimage.2011.06.078
   Spijker AT, 2009, BIPOLAR DISORD, V11, P95, DOI 10.1111/j.1399-5618.2008.00647.x
   Stechschulte LA, 2014, J BIOL CHEM, V289, P17885, DOI 10.1074/jbc.M113.544072
   Stratakis C. A., 1994, ANN NY ACAD SCI, V746, p[366, 362]
   Syed AA, 2006, OBESITY, V14, P759, DOI 10.1038/oby.2006.86
   Szczepankiewicz A, 2011, J AFFECT DISORDERS, V134, P138, DOI 10.1016/j.jad.2011.06.020
   Trementino L, 2012, EUR J ENDOCRINOL, V166, P35, DOI 10.1530/EJE-11-0722
   Ulrich-Lai YM, 2016, CURR OPIN BEHAV SCI, V9, P78, DOI 10.1016/j.cobeha.2016.02.015
   United States Department of Agriculture (USDA), STAND REF REL 26
   van Rossum EFC, 2002, DIABETES, V51, P3128, DOI 10.2337/diabetes.51.10.3128
   van Strien T, 2013, PSYCHONEUROENDOCRINO, V38, P677, DOI 10.1016/j.psyneuen.2012.08.008
   Wand GS, 2007, NEUROPSYCHOPHARMACOL, V32, P2310, DOI 10.1038/sj.npp.1301373
   Warne JP, 2009, MOL CELL ENDOCRINOL, V300, P137, DOI 10.1016/j.mce.2008.09.036
   World Health Organization, 2015, GLOB HLTH OBS DAT OV
   Wüst S, 2004, J CLIN ENDOCR METAB, V89, P565, DOI 10.1210/jc.2003-031148
   Zhou JG, 2005, STEROIDS, V70, P407, DOI 10.1016/j.steroids.2005.02.006
NR 67
TC 8
Z9 10
U1 0
U2 17
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0195-6663
EI 1095-8304
J9 APPETITE
JI Appetite
PD SEP 1
PY 2017
VL 116
BP 21
EP 28
DI 10.1016/j.appet.2017.04.004
PG 8
WC Behavioral Sciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Nutrition & Dietetics
GA FB2KM
UT WOS:000405972700003
PM 28400302
OA Green Published
DA 2025-06-11
ER

PT J
AU Strawbridge, AB
   Elmendorf, JS
AF Strawbridge, AB
   Elmendorf, JS
TI Endothelin-1 impairs glucose transporter trafficking via a
   membrane-based mechanism
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Article
DE actin; Cbl; insulin resistance; phosphatidylinositol 4,5-bispliosphate
ID INSULIN-RESISTANCE SYNDROME; TYPE-2 DIABETES-MELLITUS;
   PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE; PLASMA ENDOTHELIN-1;
   GLUCOSE-TRANSPORTER-4 TRANSLOCATION; GLUT4 TRANSLOCATION; ACTIN
   CYTOSKELETON; FILAMENTOUS ACTIN; 3T3-L1 ADIPOCYTES; SIGNALING PATHWAY
AB Endothelin-1 (ET-1) disrupts insulin-regulated glucose transporter GLUT4 trafficking. Since the negative consequence of chronic ET-1 exposure appears to be independent of signal disturbance along the insulin receptor substrate-1/phosphatidyl inositol (PI) 3-kinase (PI3K)/Akt-2 pathway Of insulin action, we tested if ET-1 altered GLUT4 regulation engaged by osmotic shock, a PI3K-independent Stimulus that mimics insulin action. Regulation of GLUT4 by hyperosmotic stress was impaired by ET-1. Because of the mutual disruption of both insulin- and hyperosmolarity-stimulated GLUT4 translocation, we tested whether shared signaling and/or key phosphatidylinositol 4,5-bisphosphate (PIP2)-regulated cytoskeletal events of GLUT4 trafficking were targets of ET-1. Both insulin and hyperosmotic stress signaling to Cbl were impaired by ET-1. Also, plasma membrane PIP2 and cortical actin levels were reduced in cells exposed to ET-1. Exogenous PIP2, but not PI 3,4,5-bisphosphate, restored actin structure, Cbl activation, and GLUT4 translocation. These data show that ET-1-induced PIP2/actin disruption impairs GLUT4 trafficking elicited by insulin and hyperosmolarity. In addition to showing for the first time the important role Of PIP2-regulated cytoskeletal events in GLUT4 regulation by stimuli other than insulin, these studies reveal a novel function Of PIP2/actin structure in signal transduction.
C1 Indiana Univ, Sch Med, Ctr Diabet Res, Dept Cellular & Integrat Physiol, Indianapolis, IN USA.
   Indiana Univ, Sch Med, Ctr Diabet Res, Dept Biochem & Mol Biol, Indianapolis, IN USA.
C3 Indiana University System; Indiana University Indianapolis; Indiana
   University System; Indiana University Indianapolis
RP 635 Barnhill Dr,MS308A, Indianapolis, IN 46202 USA.
EM jelmendo@iupui.edu
FU NCCIH NIH HHS [R01 AT001846, R01-AT001846] Funding Source: Medline
CR Ahmed Z, 2000, FEBS LETT, V475, P31, DOI 10.1016/S0014-5793(00)01621-5
   Ahn MY, 2004, J BIOL CHEM, V279, P21526, DOI 10.1074/jbc.M307740200
   Ak G, 2001, J DIABETES COMPLICAT, V15, P150, DOI 10.1016/S1056-8727(01)00137-4
   Andronico G, 1997, J HUM HYPERTENS, V11, P63, DOI 10.1038/sj.jhh.1000386
   Bandyopadhyay G, 1997, J BIOL CHEM, V272, P2551
   Baumann CA, 2000, NATURE, V407, P202, DOI 10.1038/35025089
   Brozinick JT, 2004, J BIOL CHEM, V279, P40699, DOI 10.1074/jbc.M402697200
   Caballero AE, 1999, DIABETES, V48, P1856, DOI 10.2337/diabetes.48.9.1856
   Chen D, 1997, J BIOL CHEM, V272, P27401, DOI 10.1074/jbc.272.43.27401
   Chen GL, 2004, J BIOL CHEM, V279, P39705, DOI 10.1074/jbc.C400171200
   CHOU YC, 1994, BIOCHEM BIOPH RES CO, V202, P688, DOI 10.1006/bbrc.1994.1985
   Diamanti-Kandarakis E, 2001, J CLIN ENDOCR METAB, V86, P4666, DOI 10.1210/jc.86.10.4666
   Elmendorf JS, 2002, J MEMBRANE BIOL, V190, P167, DOI 10.1007/s00232-002-1035-3
   Ferri C, 1997, EXP CLIN ENDOCR DIAB, V105, P38, DOI 10.1055/s-0029-1211794
   FERRIS W, 1995, SOUTH CULT, V1, P431, DOI 10.1353/scu.1995.0043
   Gual P, 2002, J BIOL CHEM, V277, P43980, DOI 10.1074/jbc.M203042200
   Hilpelä P, 2004, CURR TOP MICROBIOL, V282, P117
   Hsueh Willa A., 1998, American Journal of Medicine, V105, p4S, DOI 10.1016/S0002-9343(98)00205-8
   Idris I, 2001, BIOCHEM PHARMACOL, V62, P1705, DOI 10.1016/S0006-2952(01)00815-2
   Irving RJ, 2001, QJM-INT J MED, V94, P321, DOI 10.1093/qjmed/94.6.321
   Ishibashi K, 2001, J CLIN INVEST, V107, P1193, DOI 10.1172/JCI11753
   JIANG Y, 1999, GUANGZHOU CHEM, V3, P48
   Jiang ZY, 2002, J BIOL CHEM, V277, P509, DOI 10.1074/jbc.M108280200
   Juan CC, 1996, BIOCHEM BIOPH RES CO, V227, P694, DOI 10.1006/bbrc.1996.1571
   Kanzaki M, 2002, MOL BIOL CELL, V13, P2334, DOI 10.1091/mbc.01-10-0490
   Kanzaki M, 2002, J BIOL CHEM, V277, P25867, DOI 10.1074/jbc.C200292200
   Kanzaki M, 2001, J BIOL CHEM, V276, P42436, DOI 10.1074/jbc.M108297200
   Kanzaki M, 2004, J BIOL CHEM, V279, P30622, DOI 10.1074/jbc.M401443200
   Kanzaki M, 2001, J BIOL CHEM, V276, P49331, DOI 10.1074/jbc.M109657200
   Kohn AD, 1996, J BIOL CHEM, V271, P31372, DOI 10.1074/jbc.271.49.31372
   Kralik SF, 2002, ENDOCRINOLOGY, V143, P37, DOI 10.1210/en.143.1.37
   Kwik J, 2003, P NATL ACAD SCI USA, V100, P13964, DOI 10.1073/pnas.2336102100
   Laux T, 2000, J CELL BIOL, V149, P1455, DOI 10.1083/jcb.149.7.1455
   Liu J, 2003, J BIOL CHEM, V278, P36754, DOI 10.1074/jbc.M300664200
   Mangiafico RA, 1998, INT ANGIOL, V17, P97
   Minami A, 2003, DIABETES, V52, P2657, DOI 10.2337/diabetes.52.11.2657
   Mitra P, 2004, J BIOL CHEM, V279, P37431, DOI 10.1074/jbc.C400180200
   OttossonSeeberger A, 1997, ACTA PHYSIOL SCAND, V161, P211, DOI 10.1046/j.1365-201X.1997.00212.x
   Piatti P, 1999, J AM COLL CARDIOL, V34, P1452, DOI 10.1016/S0735-1097(99)00379-4
   Piatti PM, 2000, METABOLISM, V49, P748, DOI 10.1053/meta.2000.6257
   Razidlo GL, 2004, J BIOL CHEM, V279, P47808, DOI 10.1074/jbc.M406395200
   Sánchez SS, 2001, HORM METAB RES, V33, P748, DOI 10.1055/s-2001-19137
   Sayama H, 1999, GERONTOLOGY, V45, P312, DOI 10.1159/000022111
   Sechi AS, 2000, J CELL SCI, V113, P3685
   Seljeflot I, 1998, METABOLISM, V47, P292, DOI 10.1016/S0026-0495(98)90259-1
   Shibasaki Y, 1997, J BIOL CHEM, V272, P7578, DOI 10.1074/jbc.272.12.7578
   Strawbridge AB, 2005, DIABETES, V54, P1698, DOI 10.2337/diabetes.54.6.1698
   TAKAHASHI K, 1990, DIABETOLOGIA, V33, P306, DOI 10.1007/BF00403325
   Takenawa T, 1999, CHEM PHYS LIPIDS, V98, P13, DOI 10.1016/S0009-3084(99)00014-6
   Teuscher AU, 1998, J HYPERTENS, V16, P1279, DOI 10.1097/00004872-199816090-00009
   Tsakiridis T, 1999, MICROSC RES TECHNIQ, V47, P79, DOI 10.1002/(SICI)1097-0029(19991015)47:2<79::AID-JEMT1>3.0.CO;2-S
   Watson RT, 2001, EXP CELL RES, V271, P75, DOI 10.1006/excr.2001.5375
   WHITE MF, 1994, J BIOL CHEM, V269, P1
   Wilkes JJ, 2003, DIABETES, V52, P1904, DOI 10.2337/diabetes.52.8.1904
   Wong SKF, 2004, ANAL BIOCHEM, V333, P265, DOI 10.1016/j.ab.2004.05.011
NR 55
TC 22
Z9 27
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-2312
EI 1097-4644
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 1
PY 2006
VL 97
IS 4
BP 849
EP 856
DI 10.1002/jcb.20687
PG 8
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 021BV
UT WOS:000235958500018
PM 16240321
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Dwyer, BE
   Zacharski, LR
   Balestra, DJ
   Lerner, AJ
   Perry, G
   Zhu, XW
   Smith, MA
AF Dwyer, Barney E.
   Zacharski, Leo R.
   Balestra, Dominic J.
   Lerner, Alan J.
   Perry, George
   Zhu, Xiongwei
   Smith, Mark A.
TI Getting the iron out: Phlebotomy for Alzheimer's disease?
SO MEDICAL HYPOTHESES
LA English
DT Article
ID INSULIN-RESISTANCE SYNDROME; INDUCED OXIDATIVE STRESS; BRAIN FERRITIN
   IRON; BODY IRON; TAU PHOSPHORYLATION; RESPONSIVE ELEMENT; VASCULAR
   DISORDER; SENILE PLAQUES; STORED IRON; ATHEROSCLEROSIS
AB This communication explores the temporal link between the age-associated increase in body iron stores and the age-related incidence of Alzheimer's disease (AD), the most prevalent cause of senile dementia. Body iron stores that increase with age could be pivotal to AD pathogenesis and progression. Increased stored iron is associated with common medical conditions such as diabetes and vascular disease that increase risk for development of AD. Increased stored iron could also promote oxidative stress/free radical damage in vulnerable neurons, a critical early change in AD. A ferrocentric model of AD described here forms the basis of a rational, easily testable experimental therapeutic approach for AD, which if successful, would be both widely applicable and inexpensive. Clinical studies have shown that calibrated phlebotomy is an effective way to reduce stored iron safely and predictably without causing anemia. We hypothesize that reducing stored iron by calibrated phlebotomy to avoid iron deficiency will improve cerebrovascular function, slow neurodegenerative change, and improve cognitive and behavioral functions in AD. The hypothesis is eminently testable as iron reduction therapy is useful for chronic diseases associated with iron excess such as nonalcoholic steatohepatitis (NASH), atherosclerosis, hereditary hemochromatosis and thalassemia. Testing this hypothesis could provide valuable insight into the causation of AD and suggest novel preventive and treatment strategies. Published by Elsevier Ltd.
C1 [Dwyer, Barney E.; Zacharski, Leo R.; Balestra, Dominic J.] Dept Vet Affairs Med Ctr, Res Serv, White River Jct, VT USA.
   [Dwyer, Barney E.; Zacharski, Leo R.; Balestra, Dominic J.] Dartmouth Med Sch, Dept Med, Lebanon, NH USA.
   [Lerner, Alan J.] Univ Hosp Case Med Ctr, Dept Neurol, Cleveland, OH USA.
   [Perry, George; Zhu, Xiongwei; Smith, Mark A.] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA.
   [Perry, George] Univ Texas San Antonio, Coll Sci, San Antonio, TX USA.
C3 Dartmouth College; University System of Ohio; Case Western Reserve
   University; Case Western Reserve University Hospital; University System
   of Ohio; Case Western Reserve University; University of Texas System;
   University of Texas at San Antonio (UTSA)
RP Dwyer, BE (corresponding author), VA Med Ctr, Res Serv 151, 215 N Main St, White River Jct, VT 05009 USA.
EM Barney.E.Dwyer@Dartmouth.edu; mark.smith@case.edu
RI Smith, Mark/A-9053-2009; Zhu, Xiongwei/A-9629-2009; Perry,
   George/A-8611-2009
OI Perry, George/0000-0002-6547-0172
FU NIA NIH HHS [R01 AG026151, R01 AG024028] Funding Source: Medline
CR Aliev G, 2003, NEUROTOX RES, V5, P491, DOI 10.1007/BF03033159
   Amit T, 2008, FASEB J, V22, P1296, DOI 10.1096/fj.07-8627rev
   Bartzokis G, 2004, ANN NY ACAD SCI, V1012, P224, DOI 10.1196/annals.1306.019
   Bartzokis G, 2007, NEUROBIOL AGING, V28, P414, DOI 10.1016/j.neurobiolaging.2006.02.005
   Batts KP, 2007, MODERN PATHOL, V20, pS31, DOI 10.1038/modpathol.3800715
   Bradbury MWB, 1997, J NEUROCHEM, V69, P443
   Brewer GJ, 2007, EXP BIOL MED, V232, P323
   Burdo JR, 2001, J NEUROSCI RES, V66, P1198, DOI 10.1002/jnr.1256.abs
   Bush AI, 2003, TRENDS NEUROSCI, V26, P207, DOI 10.1016/S0166-2236(03)00067-5
   Castellani RJ, 1999, FREE RADICAL BIO MED, V26, P1508, DOI 10.1016/S0891-5849(99)00016-7
   Castellani RJ, 2008, INT J MOL SCI, V9, P789, DOI 10.3390/ijms9050789
   Castellani RJ, 2006, ACTA NEUROPATHOL, V111, P503, DOI 10.1007/s00401-006-0071-y
   Castellani RJ, 2007, NEUROCHEM RES, V32, P1640, DOI 10.1007/s11064-007-9360-7
   Connor JR, 2006, J ALZHEIMERS DIS, V10, P267
   CONNOR JR, 1995, J NEUROCHEM, V65, P717
   Craft S, 2006, ALZ DIS ASSOC DIS, V20, P298, DOI 10.1097/01.wad.0000213866.86934.7e
   Cullen KM, 2006, NEUROBIOL AGING, V27, P1786, DOI 10.1016/j.neurobiolaging.2005.10.016
   Cullen KM, 2005, J CEREBR BLOOD F MET, V25, P1656, DOI 10.1038/sj.jcbfm.9600155
   de la Torre JC, 2002, J ALZHEIMERS DIS, V4, P497, DOI 10.3233/jad-2002-4606
   de la Torre JC, 2005, ANN NEUROL, V57, P783, DOI 10.1002/ana.20516
   de la Torre JC, 2004, LANCET NEUROL, V3, P184, DOI 10.1016/S1474-4422(04)00683-0
   de la Torre JC, 2002, STROKE, V33, P1152, DOI 10.1161/01.STR.0000014421.15948.67
   Dunn LL, 2007, TRENDS CELL BIOL, V17, P93, DOI 10.1016/j.tcb.2006.12.003
   Egaña JT, 2003, BIOMETALS, V16, P215, DOI 10.1023/A:1020727218493
   Failla M, 2000, HEPATOLOGY, V32, P569, DOI 10.1053/jhep.2000.16265
   Farris W, 2003, P NATL ACAD SCI USA, V100, P4162, DOI 10.1073/pnas.0230450100
   Fernández-Real JM, 2002, DIABETES, V51, P2348, DOI 10.2337/diabetes.51.8.2348
   Forouhi NG, 2007, DIABETOLOGIA, V50, P949, DOI 10.1007/s00125-007-0604-5
   Gaenzer H, 2002, J AM COLL CARDIOL, V40, P2189, DOI 10.1016/S0735-1097(02)02611-6
   Ghribi O, 2006, J NEUROCHEM, V99, P438, DOI 10.1111/j.1471-4159.2006.04079.x
   GONZALEZCUYAR LF, 2008, NEUROPATHOLOGY, DOI DOI 10.1111/J.1440-1789.2008.00901
   GRUNDKEIQBAL I, 1990, ACTA NEUROPATHOL, V81, P105, DOI 10.1007/BF00334497
   Hahn P, 2004, P NATL ACAD SCI USA, V101, P13850, DOI 10.1073/pnas.0405146101
   Hahn P, 2004, MOL VIS, V10, P598
   Haidari M, 2001, CLIN CHEM, V47, P1666
   Hofman A, 1997, LANCET, V349, P151, DOI 10.1016/S0140-6736(96)09328-2
   Honda K, 2005, J BIOL CHEM, V280, P20978, DOI 10.1074/jbc.M500526200
   Hwang EM, 2006, BIOCHEM BIOPH RES CO, V349, P654, DOI 10.1016/j.bbrc.2006.08.077
   Jehn ML, 2007, AM J EPIDEMIOL, V165, P1047, DOI 10.1093/aje/kwk093
   Jiang R, 2004, JAMA-J AM MED ASSOC, V291, P711, DOI 10.1001/jama.291.6.711
   Johanson CE, 2008, FLUIDS BARRIERS CNS, V5, DOI 10.1186/1743-8454-5-10
   Kalback W, 2004, NEUROL RES, V26, P525, DOI 10.1179/016164104225017668
   KONDZIELLA D, 2008, J NEUROL SCI, DOI DOI 10.1016/J.JNS.2008.06.00
   Kruszewski M, 2003, MUTAT RES-FUND MOL M, V531, P81, DOI 10.1016/j.mrfmmm.2003.08.004
   Loeffler DA, 2001, FREE RADICAL RES, V35, P111, DOI 10.1080/10715760100300651
   Lovell MA, 2007, J NEUROSCI RES, V85, P3036, DOI 10.1002/jnr.21346
   Luchsinger JA, 2007, ARCH NEUROL-CHICAGO, V64, P570, DOI 10.1001/archneur.64.4.570
   Luchsinger JA, 2008, EUR J PHARMACOL, V585, P119, DOI 10.1016/j.ejphar.2008.02.048
   McDowell I, 2001, AGING CLIN EXP RES, V13, P143, DOI 10.1007/BF03351474
   MCLACHLAN DRC, 1991, LANCET, V337, P1304, DOI 10.1016/0140-6736(91)92978-B
   Meyers DG, 2002, TRANSFUSION, V42, P1135, DOI 10.1046/j.1537-2995.2002.00186.x
   Millan M, 2007, STROKE, V38, P90, DOI 10.1161/01.STR.0000251798.25803.e0
   Miyajima H, 1997, ANN NEUROL, V41, P404, DOI 10.1002/ana.410410318
   Moos Torben, 2006, Semin Pediatr Neurol, V13, P149, DOI 10.1016/j.spen.2006.08.003
   Mueller PP, 2006, BIOMATERIALS, V27, P2193, DOI 10.1016/j.biomaterials.2005.10.042
   Ong WY, 2004, ANN NY ACAD SCI, V1012, P51, DOI 10.1196/annals.1306.005
   Petrat F, 2002, BIOL CHEM, V383, P489, DOI 10.1515/BC.2002.051
   Piñero DJ, 2000, CELL MOL BIOL, V46, P761
   Puglielli L, 2003, NAT NEUROSCI, V6, P345, DOI 10.1038/nn0403-345
   Rao G, 2001, AM FAM PHYSICIAN, V63, P1159
   REIF DW, 1992, FREE RADICAL BIO MED, V12, P417, DOI 10.1016/0891-5849(92)90091-T
   Reiman EM, 2004, P NATL ACAD SCI USA, V101, P284, DOI 10.1073/pnas.2635903100
   Ren MQ, 2005, FREE RADICAL BIO MED, V38, P1206, DOI 10.1016/j.freeradbiomed.2005.01.008
   Rogers JT, 2002, J BIOL CHEM, V277, P45518, DOI 10.1074/jbc.M207435200
   Rouault Tracey A, 2006, Semin Pediatr Neurol, V13, P142, DOI 10.1016/j.spen.2006.08.002
   Ruitenberg A, 2005, ANN NEUROL, V57, P789, DOI 10.1002/ana.20493
   Salonen JT, 1998, AM J EPIDEMIOL, V148, P445
   Sayre LM, 2000, J NEUROCHEM, V74, P270, DOI 10.1046/j.1471-4159.2000.0740270.x
   Schipper HM, 2004, AGEING RES REV, V3, P265, DOI 10.1016/j.arr.2004.02.001
   Shinall H, 2005, BIOCHEMISTRY-US, V44, P15345, DOI 10.1021/bi050650l
   Silvestri L, 2008, J CELL MOL MED, V12, P1548, DOI 10.1111/j.1582-4934.2008.00356.x
   Smith MA, 1998, BRAIN RES, V788, P232, DOI 10.1016/S0006-8993(98)00002-X
   Smith MA, 1997, P NATL ACAD SCI USA, V94, P9866, DOI 10.1073/pnas.94.18.9866
   Stokin GB, 2005, SCIENCE, V307, P1282, DOI 10.1126/science.1105681
   Sullivan JL, 2005, ARTERIOSCL THROM VAS, V25, P1532, DOI 10.1161/01.ATV.0000174124.20147.22
   Sullivan JL, 2004, J LAB CLIN MED, V144, P280, DOI 10.1016/j.lab.2004.10.006
   SULLIVAN JL, 1981, LANCET, V1, P1293
   Sullivan JL, 2001, J NUTR BIOCHEM, V12, P33, DOI 10.1016/S0955-2863(00)00142-X
   Swaminathan S, 2007, DIABETES CARE, V30, P1926, DOI 10.2337/dc06-2625
   Valenti L, 2007, AM J GASTROENTEROL, V102, P1251, DOI 10.1111/j.1572-0241.2007.01192.x
   Vari IS, 2007, DIABETES CARE, V30, P1795, DOI 10.2337/dc06-2312
   Wang J, 2005, J NEUROCHEM, V93, P953, DOI 10.1111/j.1471-4159.2005.03053.x
   Whitnall Megan, 2006, Semin Pediatr Neurol, V13, P186, DOI 10.1016/j.spen.2006.08.008
   Wu LJC, 2004, BRAIN RES, V1001, P108, DOI 10.1016/j.brainres.2003.10.066
   Yang Y, 2007, BBA-MOL BASIS DIS, V1772, P457, DOI 10.1016/j.bbadis.2006.10.002
   Zacharski LR, 2007, JAMA-J AM MED ASSOC, V297, P603, DOI 10.1001/jama.297.6.603
   Zacharski LR, 2003, VASC MED, V8, P153, DOI 10.1191/1358863x03vm492ed
   Zacharski LR, 2000, AM HEART J, V139, P337, DOI 10.1016/S0002-8703(00)90244-8
   Zacharski LR, 2000, AM HEART J, V140, P98, DOI 10.1067/mhj.2000.106646
   Zecca L, 2004, NAT REV NEUROSCI, V5, P863, DOI 10.1038/nrn1537
   Zheng HY, 2005, ARTERIOSCL THROM VAS, V25, P1577, DOI 10.1161/01.ATV.0000174126.28201.61
   Zhu X, 2007, CELL MOL LIFE SCI, V64, P2202, DOI 10.1007/s00018-007-7218-4
   ZHU X, 2006, BIOCHIM BIOPHYS ACTA, V1772, P494
   Zhu XW, 2007, J NEUROL SCI, V257, P240, DOI 10.1016/j.jns.2007.01.039
   Zhu XW, 2000, J NEUROPATH EXP NEUR, V59, P880, DOI 10.1093/jnen/59.10.880
   Zhu XW, 2005, TRENDS MOL MED, V11, P391, DOI 10.1016/j.molmed.2005.07.002
   Zhu XW, 2004, BRAIN RES, V1000, P32, DOI 10.1016/j.brainres.2004.01.012
NR 97
TC 28
Z9 30
U1 0
U2 6
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD MAY
PY 2009
VL 72
IS 5
BP 504
EP 509
DI 10.1016/j.mehy.2008.12.029
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 426XW
UT WOS:000264742800006
PM 19195795
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Menon, K
   Cameron, JD
   de Courten, M
   de Courten, B
AF Menon, Kirthi
   Cameron, James D.
   de Courten, Maximilian
   de Courten, Barbora
TI Use of carnosine in the prevention of cardiometabolic risk factors in
   overweight and obese individuals: study protocol for a randomised,
   double-blind placebo-controlled trial
SO BMJ OPEN
LA English
DT Article
DE general diabetes; public health; cardiology
ID GLYCATION END-PRODUCTS; EXERCISE PERFORMANCE; OXIDATIVE STRESS;
   SUPPLEMENTATION; HISTIDINE; GLUCOSE; DISEASE; TRIGLYCERIDES;
   INFLAMMATION; ASSOCIATION
AB IntroductionCarnosine, an over the counter food supplement, has been shown to improve glucose metabolism as well as cardiovascular risk factors in animal and human studies through its anti-inflammatory, antioxidative, antiglycating and chelating properties. The aim of this study is to establish if carnosine supplementation improves obesity, insulin sensitivity, insulin secretion, cardiovascular risk factors including arterial stiffness and endothelial function, and other risk factors related to diabetes and cardiovascular disease in the overweight and obese population.Methods and analysisFifty participants will be recruited to be enrolled in a double-blind randomised controlled trial. Eligible participants with a body mass index (BMI) between 25 and 40 kg/m(2) will be randomly assigned to the intervention or placebo group. Following a medical review and oral glucose tolerance test to check eligibility, participants will then undergo testing. At baseline, participants will have anthropometric measurements (BMI, dual X-ray absorptiometry and peripheral quantitative CT scan), measurements of glucose metabolism (oral glucose tolerance test, intravenous glucose tolerance test and euglycaemic hyperinsulinaemic clamp), cardiovascular measurements (central blood pressure, endothelial function and arterial stiffness), a muscle and fat biopsy, physical activity measurement, liver fibroscan, cognitive function and questionnaires to assess dietary habits, sleep quality, depression, and quality of life. Following baseline assessments, participants will be randomised to either 2g carnosine or placebo for 15 weeks. In the 15th week, all assessments will be repeated. The preplanned outcome metric is the change between baseline and follow-up measures.Ethics and disseminationThis study is approved by the Human Research Ethics Committee of Monash Health and Monash University, Australia.Trial registration numberNCT02686996.
C1 [Menon, Kirthi; de Courten, Maximilian] Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia.
   [Cameron, James D.] MonashHeart & Monash Cardiovasc Res Ctr, Melbourne, Vic, Australia.
   [Cameron, James D.; de Courten, Barbora] Monash Univ, Sch Clin Sci, Melbourne, Vic, Australia.
   [de Courten, Maximilian] Victoria Univ, Mitchell Inst, Melbourne, Vic, Australia.
C3 Monash University; Monash University; Victoria University
RP de Courten, B (corresponding author), Monash Univ, Sch Clin Sci, Melbourne, Vic, Australia.
EM barbora.decourten@monash.edu
RI Cameron, james/GQP-4595-2022; de Courten, Barbora/B-3308-2012; de
   Courten, Maximilian/B-3300-2012
OI de Courten, Barbora/0000-0001-8760-2511; Cameron,
   James/0000-0003-0589-0367; de Courten, Maximilian/0000-0001-9997-9359
FU Royal Australasian College of Physicians; Monash University
FX This work was supported by the Royal Australasian College of Physicians.
   Carnosine supplement (CarnoPureTM) is received from Flamma S.p.A, Italy.
   There are no award or grant numbers for the funds or support received.
   KM is a recipient of the Research Training Programme (RTP) scholarship
   provided by Monash University. BdC is supported by Fellows Career
   Development Fellowship from the the Royal Australasian College of
   Physicians.
CR Abe H, 2000, BIOCHEMISTRY-MOSCOW+, V65, P757
   Afdhal Nezam H, 2012, Gastroenterol Hepatol (N Y), V8, P605
   AIHW, 2017, REP DAT BURD DIS IMP
   Albrecht T, 2017, SCI REP-UK, V7, DOI 10.1038/srep44492
   Aldini G, 2005, BIOFACTORS, V24, P77, DOI 10.1002/biof.5520240109
   Aldini G, 2011, J CELL MOL MED, V15, P1339, DOI 10.1111/j.1582-4934.2010.01101.x
   [Anonymous], 2006, OB OV
   Aydin AF, 2010, PEPTIDES, V31, P67, DOI 10.1016/j.peptides.2009.11.028
   Bao YH, 2015, ASIAN AUSTRAL J ANIM, V28, P1465, DOI 10.5713/ajas.14.0604
   Barski OA, 2013, ARTERIOSCL THROM VAS, V33, P1162, DOI 10.1161/ATVBAHA.112.300572
   Baye E, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-17577-7
   Boldyrev A, 2008, REJUV RES, V11, P821, DOI 10.1089/rej.2008.0716
   Brown BE, 2014, ATHEROSCLEROSIS, V232, P403, DOI 10.1016/j.atherosclerosis.2013.11.068
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1016/0165-1781(89)90047-4
   Chan AW, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.e7586
   Cheng K, 2012, J HYPERTENS, V30, P2395, DOI 10.1097/HJH.0b013e328358bee2
   Corona C, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017971
   Coughlan MT, 2011, DIABETES, V60, P2523, DOI 10.2337/db10-1033
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   de Courten B, 2016, OBESITY, V24, P1027, DOI 10.1002/oby.21434
   Derosa G, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17111802
   Diabetes Prevention Progam, 2005, DIABETES, V54, P1150
   Dobrota D, 2005, NEUROCHEM RES, V30, P1283, DOI 10.1007/s11064-005-8799-7
   Égerházi A, 2007, PROG NEURO-PSYCHOPH, V31, P746, DOI 10.1016/j.pnpbp.2007.01.011
   Elbarbary NS, 2018, PEDIATR DIABETES, V19, P470, DOI 10.1111/pedi.12564
   Engelke K, 2008, J CLIN DENSITOM, V11, P123, DOI 10.1016/j.jocd.2007.12.010
   Everaert I, 2012, AM J PHYSIOL-RENAL, V302, pF1537, DOI 10.1152/ajprenal.00084.2012
   Fenech M, 2007, NAT PROTOC, V2, P1084, DOI 10.1038/nprot.2007.77
   Feng RN, 2013, DIABETOLOGIA, V56, P985, DOI 10.1007/s00125-013-2839-7
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Forbes JM, 2014, AMINO ACIDS, V46, P321, DOI 10.1007/s00726-013-1542-9
   Forsberg EA, 2015, J ENDOCRINOL, V225, P159, DOI 10.1530/JOE-14-0571
   Fouad AA, 2007, EUR J PHARMACOL, V572, P61, DOI 10.1016/j.ejphar.2007.06.010
   Fujii T, 2003, EUR J PHARMACOL, V474, P261, DOI 10.1016/S0014-2999(03)02079-X
   Guo X, 2012, ACTA PHARM SIN B, V2, P358, DOI 10.1016/j.apsb.2012.06.002
   Herculano B, 2013, J ALZHEIMERS DIS, V33, P983, DOI 10.3233/JAD-2012-121324
   Hipkiss AR, 2013, CHEM CENT J, V7, DOI 10.1186/1752-153X-7-38
   HIPKISS AR, 1995, FEBS LETT, V371, P81, DOI 10.1016/0014-5793(95)00849-5
   HODDES E, 1973, PSYCHOPHYSIOLOGY, V10, P431, DOI 10.1111/j.1469-8986.1973.tb00801.x
   Hoffman JR, 2015, AMINO ACIDS, V47, P627, DOI 10.1007/s00726-014-1896-7
   Houjeghani S, 2018, NUTR RES, V49, P96, DOI 10.1016/j.nutres.2017.11.003
   Kroenke K, 2009, J AFFECT DISORDERS, V114, P163, DOI 10.1016/j.jad.2008.06.026
   LAN KKG, 1983, BIOMETRIKA, V70, P659, DOI 10.2307/2336502
   Lee YT, 2005, EUR J PHARMACOL, V513, P145, DOI 10.1016/j.ejphar.2005.02.010
   Lim M, 2008, ANN NY ACAD SCI, V1150, P311, DOI 10.1196/annals.1447.011
   Liu YJ, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0138646
   Lombardi C, 2015, NUTRITION, V31, P72, DOI 10.1016/j.nut.2014.04.021
   Ma J, 2012, CNS NEUROSCI THER, V18, P745, DOI 10.1111/j.1755-5949.2012.00362.x
   Martin CA, 2011, J HYPERTENS, V29, P749, DOI 10.1097/HJH.0b013e328342eeeb
   Menon K, 2020, NUTR REV, V78, P939, DOI 10.1093/nutrit/nuaa022
   Menon K, 2020, OBES REV, V21, DOI 10.1111/obr.12975
   Mong MC, 2011, EUR J PHARMACOL, V653, P82, DOI 10.1016/j.ejphar.2010.12.001
   MONK TH, 1994, J SLEEP RES, V3, P111, DOI 10.1111/j.1365-2869.1994.tb00114.x
   Naderali EK, 2009, AM J ALZHEIMERS DIS, V24, P445, DOI 10.1177/1533317509348208
   Nagai K, 2012, AMINO ACIDS, V43, P97, DOI 10.1007/s00726-012-1251-9
   PAVLOV AR, 1993, BIOCHIM BIOPHYS ACTA, V1157, P304, DOI 10.1016/0304-4165(93)90114-N
   Pereira-Lancha LO, 2012, DIABET METAB SYND OB, V5, P75, DOI 10.2147/DMSO.S25026
   Pi-Sunyer FX, 2002, OBES SURG, V12, p6S, DOI 10.1007/BF03342140
   Rajanikant GK, 2007, STROKE, V38, P3023, DOI 10.1161/STROKEAHA.107.488502
   Sale C, 2013, AMINO ACIDS, V44, P1477, DOI 10.1007/s00726-013-1476-2
   Sauerhöfer S, 2007, DIABETES, V56, P2425, DOI 10.2337/db07-0177
   Schön M, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061196
   Solis MY, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0123857
   SVENDSEN OL, 1993, AM J CLIN NUTR, V57, P605, DOI 10.1093/ajcn/57.5.605
   Szczesniak D, 2014, ARCH GERONTOL GERIAT, V59, P485, DOI 10.1016/j.archger.2014.04.008
   Thomas P, 2009, NAT PROTOC, V4, P825, DOI 10.1038/nprot.2009.53
   Weinsier RL, 1998, AM J MED, V105, P145, DOI 10.1016/S0002-9343(98)00190-9
   WILLIAMS A, 1990, HEALTH POLICY, V16, P199
   Yan H, 2005, BBA-MOL BASIS DIS, V1741, P120, DOI 10.1016/j.bbadis.2004.11.008
   Yan SL, 2009, J FOOD SCI, V74, pH259, DOI 10.1111/j.1750-3841.2009.01330.x
   Yay A, 2014, BIOTECH HISTOCHEM, V89, P552, DOI 10.3109/10520295.2014.913811
   Yu JG, 2002, DIABETES, V51, P2968, DOI 10.2337/diabetes.51.10.2968
   Zoungas S, 2007, AM J KIDNEY DIS, V50, P622, DOI 10.1053/j.ajkd.2007.07.012
NR 73
TC 5
Z9 6
U1 0
U2 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD MAY
PY 2021
VL 11
IS 5
AR e043680
DI 10.1136/bmjopen-2020-043680
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA ZL4KH
UT WOS:000763646700012
PM 33986049
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kappes, C
   Stein, R
   Koerner, A
   Merkenschlager, A
   Kiess, W
AF Kappes, Claudia
   Stein, Robert
   Koerner, Antje
   Merkenschlager, Andreas
   Kiess, Wieland
TI Stress, Stress Reduction and Obesity in Childhood and Adolescence
SO HORMONE RESEARCH IN PAEDIATRICS
LA English
DT Review
DE Mindfulness; Stress; Childhood and adolescent obesity; Stress biology;
   Cortisol; COVID-19
ID BODY-MASS INDEX; HAIR CORTISOL CONCENTRATIONS;
   SYMPATHETIC-NERVOUS-SYSTEM; SALIVARY CORTISOL; DIURNAL CORTISOL;
   METABOLIC SYNDROME; PERCEIVED STRESS; EATING BEHAVIORS; CHILDREN; IMPACT
AB Background: Obesity in childhood and adolescence remains a great global health challenge. Stress exposure during childhood and adolescence is associated with a higher risk for obesity, yet the linkage between stress and obesity is multidimensional, and its biological and behavioral mechanisms are still not fully understood. Summary: In this literature review, we identified different types of stress exposure in children and adolescents, including first studied effects of the COVID-19 pandemic as a prolonged stress exposure and their association with obesity risk. We investigated studies on the connection of altered stress biology and behavioral pathways as well as intervention programs on stress reduction in children and adolescents with obesity. Key Messages: There is evidence that stress exposure in childhood and adolescence promotes biological and behavioral alterations that contribute to the multifactorial pathogenesis of obesity. COVID-19 related-stress presents the most current example of a negative influence on weight development in children and adolescents. However, longitudinal studies on the linkage between environmental, behavioral, and biological factors across development are few, and results are partly equivocal. Intervention programs to reduce stress in children through mindfulness might be a promising adjunctive tool in the prevention and treatment of childhood and adolescent obesity that could further offer proof of concept of theoretically elaborated cause-and-effect relationships.
C1 [Kappes, Claudia; Stein, Robert; Koerner, Antje; Merkenschlager, Andreas; Kiess, Wieland] Univ Leipzig, Univ Hosp Children & Adolescents, Med Fac, Leipzig, Germany.
   [Stein, Robert] Univ Leipzig, Helmholtz Inst Metab Obes & Vasc Res HI MAG, Helmholtz Zentrum Munchen, Leipzig, Germany.
C3 Leipzig University; Helmholtz Association; Helmholtz-Center Munich -
   German Research Center for Environmental Health; Leipzig University
RP Kappes, C (corresponding author), Univ Leipzig, Univ Hosp Children & Adolescents, Med Fac, Leipzig, Germany.
EM claudia.kappes@medizin.uni-leipzig.de
RI ; Korner, Antje/B-3988-2015
OI Stein, Robert/0000-0003-0896-9943; Korner, Antje/0000-0001-6001-0356
CR Adam TC, 2007, PHYSIOL BEHAV, V91, P449, DOI 10.1016/j.physbeh.2007.04.011
   Balantekin KN, 2012, APPETITE, V59, P298, DOI 10.1016/j.appet.2012.05.016
   Baskind MJ, 2019, PREV CHRONIC DIS, V16, DOI 10.5888/pcd16.180368
   Batelaan N, 2016, EVID-BASED MENT HEAL, V19, pE18, DOI 10.1136/eb-2015-102106
   Baum P, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054546
   Ruiz-Roso MB, 2020, NUTRIENTS, V12, DOI [10.3390/nu12061807, 10.3390/nu12082289]
   Burton P, 2007, APPETITE, V49, P191, DOI 10.1016/j.appet.2007.01.007
   Bussler S, 2017, HORM RES PAEDIAT, V88, P181, DOI 10.1159/000479510
   Champaneri S, 2013, OBESITY, V21, pE56, DOI 10.1002/oby.20047
   Charmandari E, 2005, ANNU REV PHYSIOL, V67, P259, DOI 10.1146/annurev.physiol.67.040403.120816
   Chrousos GP, 2009, NAT REV ENDOCRINOL, V5, P374, DOI 10.1038/nrendo.2009.106
   CHROUSOS GP, 1992, JAMA-J AM MED ASSOC, V267, P1244, DOI 10.1001/jama.267.9.1244
   Chung A, 2016, OBES REV, V17, P276, DOI 10.1111/obr.12360
   Cusinato M, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17228297
   Czech B, 2013, INT J CLIN EXP PATHO, V6, P1585
   Darling KE, 2019, FAM SYST HEALTH, V37, P62, DOI 10.1037/fsh0000387
   Daubenmier J, 2016, OBESITY, V24, P794, DOI 10.1002/oby.21396
   De Vriendt T, 2009, NUTR METAB CARDIOVAS, V19, P511, DOI 10.1016/j.numecd.2009.02.009
   De Vriendt T, 2012, BRIT J NUTR, V108, P371, DOI 10.1017/S0007114511005708
   Dockray S, 2009, J ADOLESCENT HEALTH, V45, P344, DOI 10.1016/j.jadohealth.2009.06.014
   Doom JR, 2020, INT J OBESITY, V44, P646, DOI 10.1038/s41366-019-0447-4
   Dubey S, 2020, DIAB MET SYND CLIN R, V14, P779, DOI 10.1016/j.dsx.2020.05.035
   Dunton GF, 2020, BMC PUBLIC HEALTH, V20, DOI 10.1186/s12889-020-09429-3
   Emmanouil CC, 2018, HORM-INT J ENDOCRINO, V17, P405, DOI 10.1007/s42000-018-0052-2
   Entringer S, 2013, CURR OPIN CLIN NUTR, V16, P320, DOI 10.1097/MCO.0b013e32835e8d80
   Figlewicz DP, 2009, AM J PHYSIOL-REG I, V296, pR9, DOI 10.1152/ajpregu.90725.2008
   Genitsaridi SM, 2020, HORM RES PAEDIAT, V92, P229, DOI 10.1159/000504913
   Geserick M, 2018, NEW ENGL J MED, V379, P1303, DOI 10.1056/NEJMoa1803527
   Gouveia MJ, 2019, APPETITE, V138, P102, DOI 10.1016/j.appet.2019.03.021
   Grassi G, 2019, HYPERTENSION, V74, P349, DOI 10.1161/HYPERTENSIONAHA.119.12885
   Gundersen C, 2011, OBES REV, V12, pe54, DOI 10.1111/j.1467-789X.2010.00813.x
   Hales CM, 2018, JAMA-J AM MED ASSOC, V319, P1723, DOI 10.1001/jama.2018.3060
   Hall JE, 2010, J BIOL CHEM, V285, P17271, DOI 10.1074/jbc.R110.113175
   Hemmingsson E, 2018, CURR OBES REP, V7, P204, DOI 10.1007/s13679-018-0310-2
   Hovens JGFM, 2015, J CLIN PSYCHIAT, V76, P931, DOI 10.4088/JCP.14m09135
   Jansen E, 2021, APPETITE, V161, DOI 10.1016/j.appet.2021.105119
   Jones-Smith JC, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0100181
   Kaufman J, 2018, J PEDIATR-US, V202, P150, DOI 10.1016/j.jpeds.2018.06.051
   Kleinendorst L, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0232990
   Körner A, 2007, PEDIATR RES, V61, P640, DOI 10.1203/01.pdr.0000262638.48304.ef
   Kumar S, 2017, MAYO CLIN PROC, V92, P251, DOI 10.1016/j.mayocp.2016.09.017
   Kumari M, 2010, J CLIN ENDOCR METAB, V95, P4415, DOI 10.1210/jc.2009-2105
   Licht CMM, 2013, J CLIN ENDOCR METAB, V98, P2484, DOI 10.1210/jc.2012-3104
   Loades ME, 2020, J AM ACAD CHILD PSY, V59, P1218, DOI 10.1016/j.jaac.2020.05.009
   López-Alarcón M, 2020, ENDOCR CONNECT, V9, P163, DOI 10.1530/EC-19-0461
   Lumeng JC, 2014, APPETITE, V73, P65, DOI 10.1016/j.appet.2013.10.016
   Mason AE, 2016, APPETITE, V100, P86, DOI 10.1016/j.appet.2016.02.009
   Michels N, 2012, APPETITE, V59, P762, DOI 10.1016/j.appet.2012.08.010
   Michels N, 2013, PSYCHONEUROENDOCRINO, V38, P1512, DOI 10.1016/j.psyneuen.2012.12.020
   Nater UM, 2009, PSYCHONEUROENDOCRINO, V34, P486, DOI 10.1016/j.psyneuen.2009.01.014
   NAYA C, INT J BEHAV NUTR PHY, P1, DOI DOI 10.1080/10253890.2020.1804852
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Papafotiou C, 2017, STRESS, V20, P217, DOI 10.1080/10253890.2017.1303830
   Parks EP, 2012, PEDIATRICS, V130, pE1096, DOI 10.1542/peds.2012-0895
   Pascoe MC, 2017, PSYCHONEUROENDOCRINO, V86, P152, DOI 10.1016/j.psyneuen.2017.08.008
   Päth G, 2001, J CLIN ENDOCR METAB, V86, P2281, DOI 10.1210/jc.86.5.2281
   Pervanidou P, 2018, HORM RES PAEDIAT, V89, P372, DOI 10.1159/000488468
   Pervanidou P, 2012, METABOLISM, V61, P611, DOI 10.1016/j.metabol.2011.10.005
   Pervanidou P, 2011, INT J PEDIATR OBES, V6, P21, DOI 10.3109/17477166.2011.615996
   Pietrobelli A, 2020, OBESITY, V28, P1382, DOI 10.1002/oby.22861
   Poulain T, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16050677
   Poulsen PH., 2019, BMC PUBLIC HLTH, V19
   Qi ZT, 2016, J PEDIATR ENDOCR MET, V29, P113, DOI 10.1515/jpem-2015-0182
   Rask E, 2002, J CLIN ENDOCR METAB, V87, P3330, DOI 10.1210/jc.87.7.3330
   Rodriguez ACI, 2015, PSYCHONEUROENDOCRINO, V62, P301, DOI 10.1016/j.psyneuen.2015.08.014
   Ruttle PL, 2013, J ADOLESCENT HEALTH, V52, P731, DOI 10.1016/j.jadohealth.2012.11.013
   Sandeep TC, 2005, DIABETES, V54, P872, DOI 10.2337/diabetes.54.3.872
   Scharlau F, 2018, STRESS, V21, P43, DOI 10.1080/10253890.2017.1392507
   Seckl JR, 2004, RECENT PROG HORM RES, V59, P359, DOI 10.1210/rp.59.1.359
   Sharkey JR, 2012, BMC PEDIATR, V12, DOI 10.1186/1471-2431-12-16
   Shomaker LB, 2019, APPETITE, V140, P213, DOI 10.1016/j.appet.2019.05.022
   Singh S, 2020, PSYCHIAT RES, V293, DOI 10.1016/j.psychres.2020.113429
   Stavrou Stavroula, 2016, J Mol Biochem, V5, P63
   Stel J, 2015, ENDOCRINOLOGY, V156, P3466, DOI 10.1210/en.2015-1434
   Stenhammar C, 2010, ACTA PAEDIATR, V99, P1205, DOI 10.1111/j.1651-2227.2010.01776.x
   STEPHENS TW, 1995, NATURE, V377, P530, DOI 10.1038/377530a0
   Stimson RH, 2017, DIABETES OBES METAB, V19, P883, DOI 10.1111/dom.12899
   Veldhorst MAB, 2014, J CLIN ENDOCR METAB, V99, P285, DOI 10.1210/jc.2013-2924
   Vogel M, 2021, JCPP ADV, V1, DOI 10.1111/jcv2.12004
   Wallis DJ, 2009, APPETITE, V52, P355, DOI 10.1016/j.appet.2008.11.007
   Wilson SM, 2014, STRESS HEALTH, V30, P91, DOI 10.1002/smi.2501
   Xu K, 2018, BIOL PSYCHOL, V131, P63, DOI 10.1016/j.biopsycho.2016.11.001
   Yang SJ, 2020, CLIN OBES, V10, DOI 10.1111/cob.12416
   Zarychta K, 2016, APPETITE, V96, P47, DOI 10.1016/j.appet.2015.08.040
   Zheng W, 2017, INT J OBESITY, V41, P606, DOI 10.1038/ijo.2017.6
NR 85
TC 23
Z9 23
U1 4
U2 32
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1663-2818
EI 1663-2826
J9 HORM RES PAEDIAT
JI Horm. Res. Paediatr.
PD MAR
PY 2023
VL 96
IS 1
BP 88
EP 96
DI 10.1159/000519284
PG 9
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA D3WP4
UT WOS:000968068200011
PM 34469895
OA hybrid
DA 2025-06-11
ER

PT J
AU Lee, BK
   Durairaj, A
   Mehra, A
   Wenby, RB
   Meiselman, HJ
   Alexy, T
AF Lee, Byoung Kwon
   Durairaj, Azhil
   Mehra, Anilkumar
   Wenby, Rosalinda B.
   Meiselman, Herbert J.
   Alexy, Tamas
TI Microcirculatory dysfunction in cardiac syndrome X: Role of abnormal
   blood rheology
SO MICROCIRCULATION
LA English
DT Article
DE angina with normal coronary; cardiac syndrome X; blood rheology;
   erythrocyte aggregation
ID NORMAL CORONARY ARTERIOGRAMS; MYOCARDIAL HEMATOCRIT GRADIENT; WALL
   SHEAR-STRESS; CELL AGGREGATION; ANGINA-PECTORIS; CHEST-PAIN;
   MICROVASCULAR DYSFUNCTION; ENDOTHELIAL DYSFUNCTION; ARTERY-DISEASE;
   CLINICAL PRESENTATION
AB Objective: Cardiac syndrome X (CSX) is of clinical interest, yet the underlying pathophysiological mechanisms have not been fully elucidated. It is well known that elevated blood viscosity and red blood cell (RBC) aggregation can adversely affect microcirculatory blood flow. The present study was designed to explore whether CSX is associated with abnormalities of blood rheology.
   Methods: Blood samples were obtained from 152 adult angina patients undergoing diagnostic coronary angiography; geometric and flow-velocity data were obtained. Rheologic measurements were performed in a blinded manner; 21 subjects were later identified with CSX. Hemorheologic and clinical laboratory data were compared to 21 age- and gender-matched healthy controls.
   Results: CSX patients had markedly abnormal blood rheology: (1) higher RBC aggregation and aggregability as judged by erythrocyte sedimentation rate and Myrenne indices at stasis and low shear (p < 0.001) and (2) elevated hematocrit-corrected blood viscosity, plasma viscosity (p < 0.001), and yield stress (p < 0.01). White blood cell counts and high-sensitivity C-reactive protein levels were significantly elevated in CSX; coronary-flow velocities were below normal.
   Conclusions: Abnormal hemorheologic parameters exist in subjects with CSX and may contribute to the pathophysiology of the disease, presumably via adversely affecting blood flow in the coronary microcirculation. Therapeutic measures aimed at normalizing blood rheology and hence microcirculatory flow should be explored.
C1 [Lee, Byoung Kwon; Wenby, Rosalinda B.; Meiselman, Herbert J.; Alexy, Tamas] Univ So Calif, Keck Sch Med, Dept Phys & Biophys, Los Angeles, CA 90033 USA.
   [Lee, Byoung Kwon] Inje Univ, Coll Med, Div Cardiovasc, Sanggyepaik Hosp, Seoul, South Korea.
   [Durairaj, Azhil; Mehra, Anilkumar] Univ So Calif, Keck Sch Med, Div Cardiovasc Med, Los Angeles, CA 90033 USA.
C3 University of Southern California; Inje University; University of
   Southern California
RP Alexy, T (corresponding author), Univ So Calif, Keck Sch Med, Dept Phys & Biophys, 1333 San Pablo St,MMR 230, Los Angeles, CA 90033 USA.
EM alexy@usc.edu
RI Lee, Jeong Hoon/AAF-2400-2020
FU NHLBI NIH HHS [HL15722, HL70595] Funding Source: Medline
CR Al Suwaidi J, 2001, MAYO CLIN PROC, V76, P813
   Arroyo-Espliguero R, 2006, CAN MED ASSOC J, V174, P1833, DOI 10.1503/cmaj.051331
   BASKURT OK, 1995, AM J PHYSIOL-HEART C, V268, pH260, DOI 10.1152/ajpheart.1995.268.1.H260
   BASKURT OK, 1995, CLIN HEMORHEOL, V15, P97
   Baskurt OK, 2004, AM J PHYSIOL-HEART C, V286, pH222, DOI 10.1152/ajpheart.00532.2003
   Baskurt OK, 2003, SEMIN THROMB HEMOST, V29, P435
   Baskurt OK, 1998, J LEUKOCYTE BIOL, V63, P89, DOI 10.1002/jlb.63.1.89
   BAUERSACHS RM, 1989, CLIN HEMORHEOL, V9, P1
   Beltrame JF, 2003, AM HEART J, V146, P84, DOI 10.1016/S0002-8703(03)00124-8
   Camici PG, 2007, NEW ENGL J MED, V356, P830, DOI 10.1056/NEJMra061889
   CANNON RO, 1987, CIRCULATION, V75, P163, DOI 10.1161/01.CIR.75.1.163
   CANNON RO, 1988, AM J CARDIOL, V61, P1338, DOI 10.1016/0002-9149(88)91180-0
   COKELET GR, 1987, HDB BIOENGINEERING
   Cosín-Sales J, 2003, J AM COLL CARDIOL, V41, P1468, DOI 10.1016/S0735-1097(03)00243-2
   CRAVERI A, 1988, CLIN HEMORHEOL, V8, P723
   Devendran T, 1975, Bibl Anat, V13, P95
   Elhabyan AK, 2004, CURR MED RES OPIN, V20, P773, DOI 10.1185/030079904125003359
   Erbel R, 1996, EUR HEART J, V17, P880
   Erdogan D, 2007, ATHEROSCLEROSIS, V191, P168, DOI 10.1016/j.atherosclerosis.2006.03.016
   ERNST E, 1993, EUR HEART J SUPPL, V14, pK82
   Fang L, 2004, CAN J CARDIOL, V20, P1433
   FORFANG K, 1977, BRIT HEART J, V39, P67
   GALASSI AR, 1993, AM J CARDIOL, V72, P134, DOI 10.1016/0002-9149(93)90148-6
   Gibson CM, 1996, CIRCULATION, V93, P879, DOI 10.1161/01.CIR.93.5.879
   Huo YL, 2007, CIRC RES, V100, P273, DOI 10.1161/01.RES.0000257777.83431.13
   Hurst T, 2006, AM J MED, V119, P560, DOI 10.1016/j.amjmed.2005.07.009
   Kaski JC, 2006, HEART, V92, P5, DOI 10.1136/hrt.2005.070318
   Kaski JC, 2004, CIRCULATION, V109, P568, DOI 10.1161/01.CIR.0000116601.58103.62
   KASKI JC, 1986, AM J CARDIOL, V58, P1242, DOI 10.1016/0002-9149(86)90390-5
   KASKI JC, 1995, AM J CARDIOL, V76, pD35
   KEMP HG, 1986, J AM COLL CARDIOL, V7, P479, DOI 10.1016/S0735-1097(86)80456-9
   Kolasinska-Kloch W, 2002, SCAND J CLIN LAB INV, V62, P7, DOI 10.1080/003655102753517145
   Lanza GA, 2007, HEART, V93, P159, DOI 10.1136/hrt.2005.067330
   Lanza GA, 1997, CIRCULATION, V96, P821
   Lekakis JP, 1998, J AM COLL CARDIOL, V31, P541, DOI 10.1016/S0735-1097(97)00542-1
   Lipowsky HH, 2005, MICROCIRCULATION, V12, P5, DOI 10.1080/10739680590894966
   Lowe GDO., 1988, CLIN BLOOD RHEOLOGY
   MATRAI A, 1987, CLIN HEMORHEOL, V7, P261
   MEISELMAN HJ, 1993, CLIN HEMORHEOL, V13, P575
   Neu B, 2002, BIOPHYS J, V83, P2482, DOI 10.1016/S0006-3495(02)75259-4
   OPHERK D, 1981, CIRCULATION, V63, P817, DOI 10.1161/01.CIR.63.4.817
   Panting JR, 2002, NEW ENGL J MED, V346, P1948, DOI 10.1056/NEJMoa012369
   Pasceri V, 1998, J AM COLL CARDIOL, V31, P62, DOI 10.1016/S0735-1097(97)00421-X
   Pérez-Martin A, 2001, CLIN HEMORHEOL MICRO, V25, P91
   Rampling MW, 2004, BIORHEOLOGY, V41, P91
   RESCH KL, 1992, ANN INTERN MED, V117, P371, DOI 10.7326/0003-4819-117-5-371
   Rosenson RS, 2003, EUR HEART J, V24, P1993, DOI 10.1016/j.ehj.2003.08.005
   Scudlova Marie, 2003, Biomedical Papers (Olomouc), V147, P207
   SENEN K, 2002, ANGIOLOGY, V346, P1948
   Solá E, 2007, CLIN HEMORHEOL MICRO, V37, P309
   Soulls JV, 2006, J BIOMECH, V39, P742, DOI 10.1016/j.jbiomech.2004.12.026
   TWEDDEL AC, 1992, BRIT HEART J, V68, P48
   van Lennep JER, 2002, CARDIOVASC RES, V53, P538, DOI 10.1016/S0008-6363(01)00388-1
   Yalcin O, 2005, BIORHEOLOGY, V42, P511
   Yalcin O, 2006, AM J PHYSIOL-HEART C, V290, pH765, DOI 10.1152/ajpheart.00756.2005
   Yalcin O, 2004, AM J PHYSIOL-HEART C, V287, pH2644, DOI 10.1152/ajpheart.00534.2004
NR 56
TC 31
Z9 34
U1 0
U2 7
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1073-9688
J9 MICROCIRCULATION
JI Microcirculation
PY 2008
VL 15
IS 5
BP 451
EP 459
DI 10.1080/10739680701797090
PG 9
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 317HP
UT WOS:000257011000008
PM 18574747
DA 2025-06-11
ER

PT J
AU Birditt, KS
   Newton, NJ
   Cranford, JA
   Webster, NJ
AF Birditt, Kira S.
   Newton, Nicky J.
   Cranford, Jim A.
   Webster, Noah J.
TI Chronic Stress and Negative Marital Quality Among Older Couples:
   Associations With Waist Circumference
SO JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL
   SCIENCES
LA English
DT Article
DE Couples; Negative marital quality; Stress; Waist circumference
ID BODY-MASS INDEX; ARTERY RISK DEVELOPMENT; SOCIAL RELATIONSHIPS;
   PSYCHOSOCIAL STRESS; GENDER-DIFFERENCES; METABOLIC SYNDROME; VISCERAL
   FAT; MARRIAGE; WEIGHT; HEALTH
AB Objective More than a third of the U.S. population of older adults is obese. The present study tests the Dyadic Biopsychosocial Model of Marriage and Health, which hypothesizes that, among married couples, individual and partner chronic stress predicts increased waist circumference and these links are exacerbated in negative quality marriages.
   Method Participants were from the nationally representative longitudinal Health and Retirement Study (HRS). A total of 2,042 married individuals (in 1,098 married couples) completed psychosocial and waist circumference assessments in 2006 and 2010. Analyses examined whether negative marital quality and chronic stress in Wave 1 (2006) were associated with changes in waist circumference over time.
   Results Actor-partner interdependence models revealed that greater partner stress, rather than individuals' own reports of stress, was associated with increased waist circumference over time. Higher perceived negative marital quality among husbands and lower negative marital quality among wives exacerbated the positive link between partner stress and waist circumference.
   Discussion Consistent with the Dyadic Biopsychosocial Model of Marriage and Health, partner stress has direct associations with waist circumference among couples and this link is moderated by negative marital quality. Thus, dyadic perceptions of stress and negative marital quality are important to consider for understanding marriage and obesity.
C1 [Birditt, Kira S.; Webster, Noah J.] Univ Michigan, Inst Social Res, Life Course Dev Program, 426 Thompson St, Ann Arbor, MI 48104 USA.
   [Newton, Nicky J.] Wilfrid Laurier Univ, Dept Psychol, Waterloo, ON, Canada.
   [Cranford, Jim A.] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; Wilfrid Laurier
   University; University of Michigan System; University of Michigan
RP Birditt, KS (corresponding author), Univ Michigan, Inst Social Res, Life Course Dev Program, 426 Thompson St, Ann Arbor, MI 48104 USA.
EM kirasb@umich.edu
FU National Institute on Aging [NIA U01AG009740]; National Institute on
   Aging [U01AG009740, P30AG024824] Funding Source: NIH RePORTER
FX The Health and Retirement Study (HRS) is sponsored by the National
   Institute on Aging (grant number NIA U01AG009740) and is conducted by
   the University of Michigan.
CR Adam TC, 2007, PHYSIOL BEHAV, V91, P449, DOI 10.1016/j.physbeh.2007.04.011
   [Anonymous], ONLINE J ISSUES NURS
   Birditt K, 2008, SOC SCI MED, V67, P1291, DOI 10.1016/j.socscimed.2008.06.029
   Birditt KS, 2016, J GERONTOL B-PSYCHOL, V71, P775, DOI 10.1093/geronb/gbv023
   Birditt KS, 2014, J GERONTOL B-PSYCHOL, V69, P188, DOI 10.1093/geronb/gbs123
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   BJORNTORP P, 1991, J INTERN MED, V230, P195
   Block JP, 2009, AM J EPIDEMIOL, V170, P181, DOI 10.1093/aje/kwp104
   Bodenmann G, 2007, PERS RELATIONSHIP, V14, P551, DOI 10.1111/j.1475-6811.2007.00171.x
   Carr D, 2006, SOC PSYCHOL QUART, V69, P127, DOI 10.1177/019027250606900202
   Carr D, 2016, J GERONTOL B-PSYCHOL, V71, P177, DOI 10.1093/geronb/gbv073
   Carr D, 2014, J MARRIAGE FAM, V76, P930, DOI 10.1111/jomf.12133
   COHEN S, 1985, PSYCHOL BULL, V98, P310, DOI 10.1037/0033-2909.98.2.310
   Crimmins E., 2008, HRS DOCUMENTATION RE, V14, P47
   Elobeid MA, 2007, OBESITY, V15, P2380, DOI 10.1038/oby.2007.282
   Fakhouri Tala H I, 2012, NCHS Data Brief, P1
   Gunderson EP, 2004, INT J OBESITY, V28, P525, DOI 10.1038/sj.ijo.0802551
   Hermann S, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-169
   HOUSE JS, 1988, SCIENCE, V241, P540, DOI 10.1037/0003-066X.59.8.676
   Huxley R, 2010, EUR J CLIN NUTR, V64, P16, DOI 10.1038/ejcn.2009.68
   Jaremka LM, 2016, CLIN PSYCHOL SCI, V4, P363, DOI 10.1177/2167702615593714
   Jeffery RW, 2002, OBES RES, V10, P809, DOI 10.1038/oby.2002.109
   Juster RP, 2010, NEUROSCI BIOBEHAV R, V35, P2, DOI 10.1016/j.neubiorev.2009.10.002
   Kenny D.A., 2006, DYADIC DATA ANAL
   Kershaw KN, 2014, AM J EPIDEMIOL, V179, P567, DOI 10.1093/aje/kwt311
   Kiecolt-Glaser JK, 2015, PSYCHONEUROENDOCRINO, V52, P239, DOI 10.1016/j.psyneuen.2014.11.018
   Kiecolt-Glaser JK, 2001, PSYCHOL BULL, V127, P472, DOI 10.1037//0033-2909.127.4.472
   Klein S, 2007, OBESITY, V15, P1061, DOI 10.1038/oby.2007.632
   Kouvonen A, 2011, AM J PUBLIC HEALTH, V101, P1474, DOI 10.2105/AJPH.2010.300115
   Lee CMY, 2008, J CLIN EPIDEMIOL, V61, P646, DOI 10.1016/j.jclinepi.2007.08.012
   Lee JM, 2010, INT J OBESITY, V34, P614, DOI 10.1038/ijo.2009.235
   Lindau ST, 2003, PERSPECT BIOL MED, V46, pS74, DOI 10.1353/pbm.2003.0055
   Liu H, 2014, J HEALTH SOC BEHAV, V55, P403, DOI 10.1177/0022146514556893
   Marniemi J, 2002, J INTERN MED, V251, P35, DOI 10.1046/j.1365-2796.2002.00921.x
   Meltzer AL, 2013, HEALTH PSYCHOL, V32, P824, DOI 10.1037/a0031593
   Neff LA, 2007, J MARRIAGE FAM, V69, P594, DOI 10.1111/j.1741-3737.2007.00394.x
   Nomaguchi KM, 2004, J MARRIAGE FAM, V66, P413, DOI 10.1111/j.1741-3737.2004.00029.x
   Rigby N., 2009, Obesity: Science to Practice, P21
   Robles TF, 2014, PSYCHOL BULL, V140, P140, DOI 10.1037/a0031859
   SCHUSTER TL, 1990, AM J COMMUN PSYCHOL, V18, P423, DOI 10.1007/BF00938116
   Seeman TE, 1996, ANN EPIDEMIOL, V6, P442, DOI 10.1016/S1047-2797(96)00095-6
   Singh Jagtar., 2009, AGR LOCATION MARKET, P1, DOI [10.1093/acprof:oso/9780195152968.001.0001/acprof-9780195152968, DOI 10.1093/ACPROF:OSO/9780195152968.001.0001, 10.1093/acprof:oso/9780195152968.001.0001]
   Smith J., 2013, Documentation Report Core Section LB
   Sobal J, 2009, OBESITY, V17, P2223, DOI 10.1038/oby.2009.64
   Stevens J, 2010, EUR J CLIN NUTR, V64, P6, DOI 10.1038/ejcn.2009.101
   Thoits PA, 2010, J HEALTH SOC BEHAV, V51, pS41, DOI 10.1177/0022146510383499
   Troxel WM, 2005, ARCH INTERN MED, V165, P1022, DOI 10.1001/archinte.165.9.1022
   Troxel WM, 2003, HEALTH PSYCHOL, V22, P300, DOI 10.1037/0278-6133.22.3.300
   Walen HR, 2000, J SOC PERS RELAT, V17, P5, DOI 10.1177/0265407500171001
   Wardle J, 2011, OBESITY, V19, P771, DOI 10.1038/oby.2010.241
   Whisman MA, 2012, HEALTH PSYCHOL, V31, P80, DOI 10.1037/a0025671
   Whisman MA, 2010, J FAM PSYCHOL, V24, P367, DOI 10.1037/a0019547
NR 52
TC 8
Z9 8
U1 3
U2 14
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5014
EI 1758-5368
J9 J GERONTOL B-PSYCHOL
JI J. Gerontol. Ser. B-Psychol. Sci. Soc. Sci.
PD FEB
PY 2019
VL 74
IS 2
BP 318
EP 328
DI 10.1093/geronb/gbw112
PG 11
WC Geriatrics & Gerontology; Gerontology; Psychology; Psychology,
   Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychology
GA HQ6ZN
UT WOS:000462568900013
PM 27664418
OA Green Published
DA 2025-06-11
ER

PT J
AU Kadkhoda, G
   Zarkesh, M
   Saidpour, A
   Oghaz, MH
   Hedayati, M
   Khalaj, A
AF Kadkhoda, Golnoosh
   Zarkesh, Maryam
   Saidpour, Atoosa
   Oghaz, Masoumeh Hajizadeh
   Hedayati, Mehdi
   Khalaj, Alireza
TI Association of dietary intake of fruit and green vegetables with PTEN
   and P53 mRNA gene expression in visceral and subcutaneous adipose
   tissues of obese and non-obese adults
SO GENE
LA English
DT Article
DE Fruit; Vegetables; P53; PTEN; Gene expression; Obesity
ID INSULIN-RESISTANCE; CARDIOMETABOLIC RISK; METABOLIC SYNDROME; OXIDATIVE
   STRESS; BODY-WEIGHT; FAT INTAKE; CONSUMPTION; HEALTH; INFLAMMATION;
   PATHWAY
AB Objective The present study investigates the association of dietary intake of fruit and green Vegetables with PTEN and P53 mRNA gene expression in visceral (VAT) and subcutaneous adipose tissues (SAT) of obese and non-obese adults.
   Methods VAT and SAT were obtained from 151 individuals, aged similar to 40 years, who had undergone elective abdominal surgery. The participants were grouped according to their body mass index (BMI), as obese (BMI > 30 kg/m(2)) and non-obese (BMI = 18.5-30 kg/m2). Dietary intakes were obtained using a valid and reliable food-frequency questionnaire (FFQ). Real-time PCR was carried out for PTEN and P53 mRNA expressions. Associations between expression levels and dietary parameters were analyzed.
   Results P53 mRNA expression of obese participants was significantly higher than the non-obese, only in VAT (p < 0.001). After adjusting for total energy intake, age and BMI, fruit intake was inversely associated with P53 gene expression in both VAT (beta = -0.38, P = 0.01) and SAT (beta = -0.35, P = 0.03) among non-obese participants. Furthermore, fruit consumption was inversely associated with P53 gene expression in obese individuals, only in VAT (beta = -0.21, P = 0.05). More so, intake of green vegetables in obese subjects was negatively associated with P53 gene expression in VAT (beta = -0.27, P = 0.01) and SAT (beta = -0.28, P < 0.001). On the other hand, after adjustment for total energy intake, age and BMI, a positive association was observed between fruit intake and PTEN in VAT (beta = 0.27, P = 0.01) and SAT (beta = 0.34, P < 0.001) among obese participants. In addition, dietary consumption of fruits in non-obese individuals was negatively associated withPTEN expression in SAT (beta = -0.48, P < 0.001).
   Conclusion Dietary intake of fruit and green vegetables was associated with P53 gene expression in VAT and SAT of obese participants, suggesting their protective role in regulating P53 mRNA expression in adipose tissue. Furthermore, higher fruit intake was inversely associated with PTEN mRNA levels in non-obese participants, implying the anti-adipogenic role of PTEN gene expression.
C1 [Kadkhoda, Golnoosh; Saidpour, Atoosa; Oghaz, Masoumeh Hajizadeh] Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, Dept Clin Nutr & Dietet, Tehran, Iran.
   [Zarkesh, Maryam; Hedayati, Mehdi] Shahid Beheshti Univ Med Sci, Cellular & Mol Endocrine Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
   [Khalaj, Alireza] Shahed Univ, Tehran Obes Treatment Ctr, Dept Surg, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Shahed University
RP Saidpour, A (corresponding author), Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, Dept Clin Nutr & Dietet, Tehran, Iran.; Zarkesh, M (corresponding author), Shahid Beheshti Univ Med Sci, Cellular & Mol Endocrine Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
EM zarkesh@endocrine.ac.ir; saidpour@sbmu.ac.ir; hedayati@endocrine.ac.ir;
   khalaj@totc.ir
RI Hedayati, Mehdi/AAG-3006-2019; Zarkesh, Maryam/ABC-1782-2021; saidpour,
   atoosa/Q-1135-2019
OI Zarkesh, Maryam/0000-0002-8519-4865; saidpour,
   atoosa/0000-0002-8442-7620
FU Research Institute for Endocrine Sciences (RIES) of the Shahid Beheshti
   University of Medical Sciences in Tehran, Iran
   [IR.SBMU.ENDOCRINE.REC.1395.283]
FX This study was funded by the Research Institute for Endocrine Sciences
   (RIES) of the Shahid Beheshti University of Medical Sciences in Tehran,
   Iran (IR.SBMU.ENDOCRINE.REC.1395.283).
CR Alinia S, 2009, OBES REV, V10, P639, DOI 10.1111/j.1467-789X.2009.00582.x
   Alonso A, 2004, BRIT J NUTR, V92, P311, DOI 10.1079/BJN20041196
   [Anonymous], [No title captured]
   [Anonymous], [No title captured]
   Asgard R., 2007, Scandinavian Journal of Food & Nutrition, V51, P149, DOI 10.1080/17482970701737285
   Asghari G, 2012, BRIT J NUTR, V108, P1109, DOI 10.1017/S0007114511006313
   Bargonetti J, 2002, CURR OPIN ONCOL, V14, P86, DOI 10.1097/00001622-200201000-00015
   Barth S, 2010, OBESITY FACTS, V3, P245, DOI 10.1159/000319508
   Blomhoff R, 2006, BRIT J NUTR, V96, pS52, DOI 10.1017/BJN20061864
   Bouali S, 2009, CANCER GENE THER, V16, P498, DOI 10.1038/cgt.2008.100
   Bustin SA, 2009, CLIN CHEM, V55, P611, DOI 10.1373/clinchem.2008.112797
   Chalhoub N, 2009, ANNU REV PATHOL-MECH, V4, P127, DOI 10.1146/annurev.pathol.4.110807.092311
   Demerath EW, 2008, AM J CLIN NUTR, V88, P1263, DOI 10.3945/ajcn.2008.26546
   Esmaillzadeh A, 2006, AM J CLIN NUTR, V84, P1489, DOI 10.1093/ajcn/84.6.1489
   Fardet A, 2010, NUTR RES REV, V23, P65, DOI 10.1017/S0954422410000041
   Ferreira I, 2005, ARCH INTERN MED, V165, P875, DOI 10.1001/archinte.165.8.875
   Freeman DJ, 2003, CANCER CELL, V3, P117, DOI 10.1016/S1535-6108(03)00021-7
   Garcia-Cao I, 2012, CELL, V149, P49, DOI 10.1016/j.cell.2012.02.030
   Goldstein I, 2015, TRENDS ENDOCRIN MET, V26, P699, DOI 10.1016/j.tem.2015.09.005
   González-Muniesa P, 2017, NAT REV DIS PRIMERS, V3, DOI 10.1038/nrdp.2017.34
   Goodpaster BH, 1997, DIABETES, V46, P1579, DOI 10.2337/diabetes.46.10.1579
   Hermsdorff HHM, 2010, NUTR METAB, V7, DOI 10.1186/1743-7075-7-42
   Holt EM, 2009, J AM DIET ASSOC, V109, P414, DOI 10.1016/j.jada.2008.11.036
   Homayounfar R, 2015, GEN COMP ENDOCR, V214, P134, DOI 10.1016/j.ygcen.2014.06.029
   Ibrahim MM, 2010, OBES REV, V11, P11, DOI 10.1111/j.1467-789X.2009.00623.x
   Klein S, 2007, OBESITY, V15, P1061, DOI 10.1038/oby.2007.632
   Kopf JC, 2018, NUTR J, V17, DOI 10.1186/s12937-018-0381-7
   Krstic J, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19092622
   Li GL, 2017, DNA CELL BIOL, V36, P672, DOI 10.1089/dna.2017.3712
   Mayo LD, 2002, TRENDS BIOCHEM SCI, V27, P462, DOI 10.1016/S0968-0004(02)02166-7
   Mirmiran P, 2010, PUBLIC HEALTH NUTR, V13, P654, DOI 10.1017/S1368980009991698
   Molchadsky A, 2013, CELL DEATH DIFFER, V20, P774, DOI 10.1038/cdd.2013.9
   Molfino A, 2018, CLIN NUTR, V37, P2186, DOI 10.1016/j.clnu.2017.10.021
   Ortega FJ, 2014, INT J OBESITY, V38, P737, DOI 10.1038/ijo.2013.163
   Ortega-Molina A, 2012, CELL METAB, V15, P382, DOI 10.1016/j.cmet.2012.02.001
   Palian BM, 2014, PLOS GENET, V10, DOI 10.1371/journal.pgen.1004789
   Porrini M, 2002, EUR J NUTR, V41, P95, DOI 10.1007/s003940200014
   Ravussin E, 2002, ANN NY ACAD SCI, V967, P363
   Rodríguez MC, 2005, PLANT FOOD HUM NUTR, V60, P219, DOI 10.1007/s11130-005-8622-2
   Rostami H, 2017, PROSTAG LEUKOTR ESS, V126, P49, DOI 10.1016/j.plefa.2017.09.010
   Shimizu I, 2012, CELL METAB, V15, P51, DOI 10.1016/j.cmet.2011.12.006
   Tan CY, 2008, BIOCHEM SOC T, V36, P935, DOI 10.1042/BST0360935
   Vasheghani-Farahani Ali, 2011, Asian J Sports Med, V2, P106
   Vergoni B, 2016, DIABETES, V65, P3062, DOI 10.2337/db16-0014
   Walley AJ, 2006, HUM MOL GENET, V15, pR124, DOI 10.1093/hmg/ddl215
   Wellen KE, 2003, J CLIN INVEST, V112, P1785, DOI 10.1172/JCI20514
   Williams EJ, 2017, NUTRIENTS, V9, DOI 10.3390/nu9020116
   Yamada KM, 2001, J CELL SCI, V114, P2375
   Yu Z, 2016, AM J CLIN NUTR, V104, P722, DOI 10.3945/ajcn.116.134205
   Yuzbashian E, 2019, NUTRITION, V63-64, P92, DOI 10.1016/j.nut.2018.12.014
   Yuzbashian E, 2019, J STEROID BIOCHEM, V187, P82, DOI 10.1016/j.jsbmb.2018.11.004
NR 51
TC 5
Z9 5
U1 0
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0378-1119
EI 1879-0038
J9 GENE
JI Gene
PD APR 5
PY 2020
VL 733
AR 144353
DI 10.1016/j.gene.2020.144353
PG 7
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA KR0ZA
UT WOS:000517347900008
PM 31978509
DA 2025-06-11
ER

PT J
AU Alazmi, AHS
   Khiriy, SA
   Khiriy, MA
   Alabdulaal, FA
   Aldossry, KMH
   Alshammari, KR
   Al Otaibi, RHS
   Alrowaily, MJ
   Sawadi, HAM
   Al-Shahrani, SN
   Alanzei, NAS
   Aldossri, BMM
   Alruwaily, KMAA
   Aldosari, HNF
   Al-Anzi, AS
   Al-Moshawwh, MA
AF Alazmi, Amnah Hameed Saleem
   Khiriy, Shujun Ahmad
   Khiriy, Muadia Ahmad
   Alabdulaal, Fatimah Abdullah
   Aldossry, Khalaf Mubark Hanian
   Alshammari, Khulud Raja
   Al Otaibi, Rehab Hamood Salim
   Alrowaily, Maram Jaber
   Sawadi, Hassan Abdoh Mohammed
   Al-Shahrani, Salhah Nasser
   Alanzei, Noha Abdullah Suliman
   Aldossri, Badar Majid Mubark
   Alruwaily, Khalid Mohammed Abed Alruwaily
   Aldosari, Haya Nasser Fahad
   Al-Anzi, Aziza Saud
   Al-Moshawwh, Majed Abdullah
TI Comprehensive Nursing Care in Coronary Heart Disease: Biochemical
   Markers, Strategies, Challenges, and Evidence-Based Approaches for
   Effective Patient Management and Outcomes
SO EGYPTIAN JOURNAL OF CHEMISTRY
LA English
DT Article
DE Coronary Heart Disease; Nursing Care; Patient Management; Pediatric
   Patients; Elderly Patients; Risk Factors; Lifestyle Modifications;
   Evidence-Based Practice; Clinical Outcomes; Mental Health
ID ARTERY-BYPASS GRAFT; RANDOMIZED CONTROLLED-TRIAL; CARDIOVASCULAR
   RISK-FACTORS; QUALITY-OF-LIFE; MYOCARDIAL-INFARCTION; SELF-CARE;
   METABOLIC SYNDROME; OBESITY; INTERVENTION; DIAGNOSIS
AB Background: Coronary heart disease (CHD) is a leading cause of morbidity and mortality globally, posing significant challenges for patient care across diverse populations. Nurses play a critical role in the prevention, management, and rehabilitation of patients with CHD, contributing to improved clinical outcomes and quality of life. This review explores evidence-based approaches and strategies for effective nursing care in CHD management, emphasizing the unique considerations for pediatric and elderly patients. Aim: The aim of this review is to critically examine the role of nurses in managing CHD, focusing on the prevention of risk factors, patient education, and care strategies across the lifespan, with particular attention to the pediatric and elderly populations. Methods: This review synthesizes findings from current literature on the role of nursing care in CHD management, including the impact of interventions aimed at change in behavioral, mental health support, and clinical outcomes. A particular focus is given to nursing interventions in the management of obesity, cardiovascular risk factors, and the distinctive challenges faced by pediatric and elderly populations with CHD. Results: Evidence shows that nursing interventions, including patient education, lifestyle modification support, and continuity of care, significantly improve self-care capacity, disease knowledge, and self-efficacy in patients with CHD. For pediatric and elderly populations, tailored care strategies are essential due to their unique physiological and psychological needs. In pediatric cases, nurses play a crucial role in early detection and family support, while in elderly patients, comprehensive care addressing polypharmacy, cognitive decline, and comorbidities is vital. Additionally, nurses have been shown to contribute to improved clinical parameters such as blood pressure, cholesterol levels, and physical activity adherence, along with better mental health outcomes. Conclusion: Nurses are central to the management and treatment of CHD, with evidence supporting the positive impact of their interventions on patient outcomes. Effective nursing care, particularly in the pediatric and elderly populations, requires a tailored, patient-centered approach that considers age-specific needs, comorbidities, and psychosocial factors. Continued research into nursing strategies and interventions is essential for optimizing care and improving long-term outcomes for patients with CHD.
C1 [Alazmi, Amnah Hameed Saleem; Al Otaibi, Rehab Hamood Salim; Al-Moshawwh, Majed Abdullah] Minist Hlth, Riyadh Hlth Cluster 1, Riyadh, Saudi Arabia.
   [Khiriy, Shujun Ahmad; Khiriy, Muadia Ahmad; Al-Shahrani, Salhah Nasser] Minist Hlth, Hlth Cluster 1, Riyadh, Saudi Arabia.
   [Alabdulaal, Fatimah Abdullah] Minist Hlth, Prince Mohammad Bin Fahd Hosp, Riyadh, Saudi Arabia.
   [Aldossry, Khalaf Mubark Hanian] Minist Hlth, Wadi Aldawasir Hosp, Riyadh, Saudi Arabia.
   [Alshammari, Khulud Raja] Minist Hlth, Erada & Mental Hlth Hosp, Riyadh, Saudi Arabia.
   [Alrowaily, Maram Jaber] Minist Hlth, Hlth Cluster 2, Riyadh, Saudi Arabia.
   [Sawadi, Hassan Abdoh Mohammed] Minist Hlth, Irada Mental Hlth Hosp Jazan Jazan Hlth Cluster, Riyadh, Saudi Arabia.
   [Alanzei, Noha Abdullah Suliman] Minist Hlth, Al Seih Hlth Care Ctr, Riyadh, Saudi Arabia.
   [Aldossri, Badar Majid Mubark] Minist Hlth, Hlth Cluster Riyadh 1, Riyadh, Saudi Arabia.
   [Alruwaily, Khalid Mohammed Abed Alruwaily] Minist Hlth, King Khalid Hosp, Al Haytham Hlth Ctr, Najran, Saudi Arabia.
   [Aldosari, Haya Nasser Fahad] Minist Hlth, Bani Malik Gen Hosp, Bani Malik St, Abha 62526, Saudi Arabia.
   [Al-Anzi, Aziza Saud] Minist Hlth, Al Qasumah Gen Hosp, Al Qassim, Saudi Arabia.
C3 Ministry of Health - Saudi Arabia; Ministry of Health - Saudi Arabia;
   Ministry of Health - Saudi Arabia; Ministry of Health - Saudi Arabia;
   Ministry of Health - Saudi Arabia; Ministry of Health - Saudi Arabia;
   Ministry of Health - Saudi Arabia; Ministry of Health - Saudi Arabia;
   Ministry of Health - Saudi Arabia; King Khalid Hospital
RP Alazmi, AHS (corresponding author), Minist Hlth, Riyadh Hlth Cluster 1, Riyadh, Saudi Arabia.
EM ahalazmi@moh.gov.sa
CR Al-Smadi AM, 2016, INT J NURS PRACT, V22, P633, DOI 10.1111/ijn.12494
   Alexander JK, 2001, AM J MED SCI, V321, P215, DOI 10.1097/00000441-200104000-00002
   Alghanem F, 2020, AM J EMERG MED, V38, P89, DOI 10.1016/j.ajem.2019.04.030
   Allen RA, 2001, EUR J CLIN INVEST, V31, P843, DOI 10.1046/j.1365-2362.2001.00907.x
   Alpert MA, 2016, Metabolic Syndrome: A Comprehensive Textbook, P619
   [Anonymous], 1996, J Am Coll Cardiol, V27, P957
   Bahit MC, 2018, JACC-HEART FAIL, V6, P179, DOI 10.1016/j.jchf.2017.09.015
   Bahr SJ, 2019, INT J NURS PRACT, V25, DOI 10.1111/ijn.12704
   Bajaj A, 2015, J INVEST MED, V63, P844, DOI 10.1097/JIM.0000000000000232
   Bamouni J, 2018, PAN AFR MED J, V31, DOI 10.11604/pamj.2018.31.229.15927
   BARRETTCONNOR EL, 1985, ANN INTERN MED, V103, P1010, DOI 10.7326/0003-4819-103-6-1010
   Bastien M, 2014, PROG CARDIOVASC DIS, V56, P369, DOI 10.1016/j.pcad.2013.10.016
   Bauersachs R, 2019, CARDIOVASC THER, V2019, DOI 10.1155/2019/8295054
   BERENSON GS, 1992, AM J CARDIOL, V70, P851, DOI 10.1016/0002-9149(92)90726-F
   Bikmoradi A, 2017, PATIENT EDUC COUNS, V100, P2290, DOI 10.1016/j.pec.2017.06.010
   Bikmoradi A, 2016, INT J MED INFORM, V86, P43, DOI 10.1016/j.ijmedinf.2015.12.001
   Buckley T, 2007, Eur J Cardiovasc Nurs, V6, P105, DOI 10.1016/j.ejcnurse.2006.05.005
   Carroll Diane L, 2006, Eur J Cardiovasc Nurs, V5, P83, DOI 10.1016/j.ejcnurse.2005.09.001
   Colella TJF, 2018, EUR J CARDIOVASC NUR, V17, P408, DOI 10.1177/1474515117725521
   Correa-Rodríguez M, 2020, J CLIN MED, V9, DOI 10.3390/jcm9040909
   Cossette S, 2012, NURS RES, V61, P119, DOI 10.1097/NNR.0b013e318240dc6b
   Dalen JE, 2014, AM J MED, V127, P807, DOI 10.1016/j.amjmed.2014.04.015
   Després JP, 2012, CIRCULATION, V126, P1301, DOI 10.1161/CIRCULATIONAHA.111.067264
   Elam MB, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0181308
   Fålun N, 2016, EUR J CARDIOVASC NUR, V15, P495, DOI 10.1177/1474515115614712
   Fredericks S, 2009, EUR J CARDIOVASC NUR, V8, P144, DOI 10.1016/j.ejcnurse.2008.10.007
   Freedman DS, 1999, PEDIATRICS, V103, P1175, DOI 10.1542/peds.103.6.1175
   Furuya RK, 2015, J ADV NURS, V71, P895, DOI 10.1111/jan.12568
   Rodríguez LAG, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0160046
   Giuliano C, 2017, CLIN MED INSIGHTS-CA, V11, DOI 10.1177/1179546817710028
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hunger M, 2015, EUR J PREV CARDIOL, V22, P442, DOI 10.1177/2047487314524682
   Irmak Z, 2010, APPL NURS RES, V23, P147, DOI 10.1016/j.apnr.2008.07.004
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jahangir E, 2014, TRANSL RES, V164, P336, DOI 10.1016/j.trsl.2014.03.010
   Jamal A, 2018, MMWR-MORBID MORTAL W, V67, P53, DOI 10.15585/mmwr.mm6702a1
   James S, 2009, AM HEART J, V157, P599, DOI 10.1016/j.ahj.2009.01.003
   Jankowski P, 2018, ARCH MED SCI, V14, P979, DOI 10.5114/aoms.2017.65236
   Katz D, 2019, ANN INTERN MED, V171, pITC17, DOI 10.7326/AITC201908060
   Koenig W, 2013, INT J CARDIOL, V168, P5126, DOI 10.1016/j.ijcard.2013.07.113
   Koliaki C, 2019, METABOLISM, V92, P98, DOI 10.1016/j.metabol.2018.10.011
   Krauss R M, 1998, Circulation, V98, P1472
   Krauss Ronald M., 1998, Circulation, V98, P1472
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lapointe F, 2006, CAN J CARDIOL, V22, P761, DOI 10.1016/S0828-282X(06)70292-6
   Makki N, 2015, J INTENSIVE CARE MED, V30, P186, DOI 10.1177/0885066613503294
   Mansilla-Chacon M, 2021, J CARDIOVASC DEV DIS, V8, DOI 10.3390/jcdd8120166
   Michniewicz E, 2018, ADV MED SCI-POLAND, V63, P30, DOI 10.1016/j.advms.2017.06.005
   Minneboo M, 2017, J AM COLL CARDIOL, V70, P318, DOI 10.1016/j.jacc.2017.05.041
   Mohammadpour A, 2015, J CLIN NURS, V24, P1686, DOI 10.1111/jocn.12775
   Molazem Z, 2013, ARYA ATHEROSCLER, V9, P186
   Mols RE, 2019, J CARDIOVASC NURS, V34, P222, DOI 10.1097/JCN.0000000000000566
   Muhammad I, 2016, INT J NURS PRACT, V22, P4, DOI 10.1111/ijn.12356
   Nakahara T, 2017, JACC-CARDIOVASC IMAG, V10, P582, DOI 10.1016/j.jcmg.2017.03.005
   Negarandeh R, 2012, EUR J CARDIOVASC NUR, V11, P460, DOI 10.1016/j.ejcnurse.2011.05.001
   Neskovic AN, 1999, CLIN CARDIOL, V22, P91, DOI 10.1002/clc.4960220207
   Poirier P, 2006, CIRCULATION, V113, P898, DOI 10.1161/CIRCULATIONAHA.106.171016
   Poirier Paul, 2002, Curr Atheroscler Rep, V4, P448, DOI 10.1007/s11883-002-0049-8
   Puymirat Etienne, 2015, Rev Prat, V65, P317
   Reed GW, 2017, LANCET, V389, P197, DOI 10.1016/S0140-6736(16)30677-8
   Reejhsinghani R, 2015, VASC HEALTH RISK MAN, V11, P93, DOI 10.2147/VHRM.S43357
   Rushton M, 2017, J CLIN NURS, V26, P5206, DOI 10.1111/jocn.14071
   Schiele F, 2017, EUR J PREV CARDIOL, V24, P88, DOI 10.1177/2047487317706586
   Schmidt-RioValle J, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17228439
   Schulte H, 1999, ATHEROSCLEROSIS, V144, P199, DOI 10.1016/S0021-9150(99)00055-6
   Sicari R, 2017, CARDIOVASC ULTRASOUN, V15, DOI 10.1186/s12947-017-0099-2
   Smith JN, 2015, J AM BOARD FAM MED, V28, P283, DOI 10.3122/jabfm.2015.02.140189
   Stevens S, 2015, NURS CLIN N AM, V50, P123, DOI 10.1016/j.cnur.2014.10.010
   Stoicea N, 2017, FRONT CARDIOVASC MED, V4, DOI 10.3389/fcvm.2017.00070
   Straka BT, 2017, J ALLERGY CLIN IMMUN, V140, P242, DOI 10.1016/j.jaci.2016.09.051
   Tabei SMB, 2014, J CARDIOVASC THORAC, V6, P51, DOI 10.5681/jcvtr.2014.010
   Todd Miller M, 2008, J Cardiometab Syndr, V3, P162, DOI 10.1111/j.1559-4572.2008.00004.x
   Uysal H, 2012, INT J NURS PRACT, V18, P445, DOI 10.1111/j.1440-172X.2012.02058.x
   Valaker I, 2017, EUR J CARDIOVASC NUR, V16, P444, DOI 10.1177/1474515117690298
   WHO Consultation, 2000, WHO TECH REP SER, V894, P1
   World Health Organisation Cardiovascular Diseases (CVDs), ABOUT US
   Wormser D, 2011, LANCET, V377, P1085, DOI 10.1016/S0140-6736(11)60105-0
   Wu Q, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0217535
   Zhang P, 2018, J CLIN NURS, V27, P969, DOI 10.1111/jocn.14064
   Zhao Y, 2009, J CLIN NURS, V18, P2444, DOI 10.1111/j.1365-2702.2009.02835.x
NR 81
TC 0
Z9 0
U1 0
U2 0
PU National Information & Documentation Centre-NIDOC
PI CAIRO
PA NIDOC DOKKI, CAIRO, 00000, EGYPT
SN 0449-2285
EI 2357-0245
J9 EGYPT J CHEM
JI Egypt. J. Chem.
PD DEC
PY 2024
VL 67
IS 13
BP 1449
EP 1463
DI 10.21608/ejchem.2024.335773.10782
PG 15
WC Chemistry, Multidisciplinary
WE Emerging Sources Citation Index (ESCI)
SC Chemistry
GA P9U0B
UT WOS:001381253100002
DA 2025-06-11
ER

PT J
AU Hamada, S
   Mae, Y
   Takata, T
   Hanada, H
   Kubo, M
   Taniguchi, S
   Iyama, T
   Sugihara, T
   Isomoto, H
AF Hamada, Shintaro
   Mae, Yukari
   Takata, Tomoaki
   Hanada, Hinako
   Kubo, Misaki
   Taniguchi, Sosuke
   Iyama, Takuji
   Sugihara, Takaaki
   Isomoto, Hajime
TI Five-Aminolevulinic Acid (5-ALA) Induces Heme Oxygenase-1 and
   Ameliorates Palmitic Acid-Induced Endoplasmic Reticulum Stress in Renal
   Tubules
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE Nrf2; Bach1; steatosis; kidney; lipotoxicity
ID CHRONIC KIDNEY-DISEASE; METABOLIC SYNDROME; OXIDATIVE STRESS; ER STRESS;
   EXPRESSION; DYSFUNCTION
AB Steatosis, or ectopic lipid deposition, is the fundamental pathophysiology of non-alcoholic steatohepatitis and chronic kidney disease. Steatosis in the renal tubule causes endoplasmic reticulum (ER) stress, leading to kidney injury. Thus, ER stress could be a therapeutic target in steatonephropathy. Five-aminolevulinic acid (5-ALA) is a natural product that induces heme oxygenase (HO)-1, which acts as an antioxidant. This study aimed to investigate the therapeutic potential of 5-ALA in lipotoxicity-induced ER stress in human primary renal proximal tubule epithelial cells. Cells were stimulated with palmitic acid (PA) to induce ER stress. Cellular apoptotic signals and expression of genes involved in the ER stress cascade and heme biosynthesis pathway were analyzed. The expression of glucose-regulated protein 78 (GRP78), a master regulator of ER stress, increased significantly, followed by increased cellular apoptosis. Administration of 5-ALA induced a remarkable increase in HO-1 expression, thus ameliorating PA-induced GRP78 expression and apoptotic signals. BTB and CNC homology 1 (BACH1), a transcriptional repressor of HO-1, was significantly downregulated by 5-ALA treatment. HO-1 induction attenuates PA-induced renal tubular injury by suppressing ER stress. This study demonstrates the therapeutic potential of 5-ALA against lipotoxicity through redox pathway.
C1 [Hamada, Shintaro; Mae, Yukari; Takata, Tomoaki; Hanada, Hinako; Kubo, Misaki; Taniguchi, Sosuke; Iyama, Takuji; Sugihara, Takaaki; Isomoto, Hajime] Tottori Univ, Fac Med, Div Gastroenterol & Nephrol, Tottori 6838504, Japan.
C3 Tottori University
RP Takata, T (corresponding author), Tottori Univ, Fac Med, Div Gastroenterol & Nephrol, Tottori 6838504, Japan.
EM t-takata@tottori-u.ac.jp
RI ; Takata, Tomoaki/AAC-9506-2020
OI Sugihara, Takaaki/0000-0003-0522-1884; Takata,
   Tomoaki/0000-0003-2959-6015
CR Alam J, 2007, AM J RESP CELL MOL, V36, P166, DOI 10.1165/rcmb.2006-0340TR
   Chitraju C, 2017, CELL METAB, V26, P407, DOI 10.1016/j.cmet.2017.07.012
   Drosatos Konstantinos, 2013, Curr Heart Fail Rep, V10, P109, DOI 10.1007/s11897-013-0133-0
   Gáll T, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20153675
   Gáll T, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01595
   Gao Z, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0149032
   Hamada S, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0265461
   Harada Y, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23126478
   Hashimoto T, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222111405
   Heo CU, 2019, J CLIN MED, V8, DOI 10.3390/jcm8030393
   Hosokawa K, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21010190
   Hoyas I, 2019, J CLIN MED, V8, DOI 10.3390/jcm8091301
   Hozumi K, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-27689-y
   Iseki K, 2008, J NEPHROL, V21, P305
   Jang HR, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-23014-0
   Kinoshita H, 2020, YONAGO ACTA MED, V63, P154, DOI 10.33160/yam.2020.08.003
   Li JW, 2020, ONCOL REP, V43, P1516, DOI 10.3892/or.2020.7517
   Li L, 2017, MOL MED REP, V16, P8055, DOI 10.3892/mmr.2017.7588
   Liu C, 2019, BIOCHEM BIOPH RES CO, V508, P583, DOI 10.1016/j.bbrc.2018.11.175
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   Luo D, 2017, AGING-US, V9, P2068, DOI 10.18632/aging.101302
   Maamoun H, 2017, BIOCHEM PHARMACOL, V127, P46, DOI 10.1016/j.bcp.2016.12.009
   Maekawa H, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00074
   Mendez-Sanchez N, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19072034
   Min SH, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-22658-2
   Nagahara R, 2019, YONAGO ACTA MED, V62, P36, DOI 10.33160/yam.2019.03.006
   Naito Y, 2014, ARCH BIOCHEM BIOPHYS, V564, P83, DOI 10.1016/j.abb.2014.09.005
   Natali A, 2009, J NEPHROL, V22, P29
   Nitta K, 2020, RENAL REPLACE THER, V6, DOI 10.1186/s41100-020-00286-9
   Ogawa K, 2001, EMBO J, V20, P2835, DOI 10.1093/emboj/20.11.2835
   Park SY, 2005, DIABETES, V54, P3530, DOI 10.2337/diabetes.54.12.3530
   Rinaldi A, 2022, JCI INSIGHT, V7, DOI 10.1172/jci.insight.161783
   Shi Y, 2018, NUTR RES, V52, P80, DOI 10.1016/j.nutres.2018.02.003
   Shoji T, 2005, INTERNAL MED, V44, P179, DOI 10.2169/internalmedicine.44.179
   Takaki A, 2013, INT J MOL SCI, V14, P20704, DOI 10.3390/ijms141020704
   Takaki H, 2017, MED SCI MONITOR, V23, P4526, DOI 10.12659/MSM.903210
   Takata T, 2022, INTERNAL MED, V63, P17, DOI 10.2169/internalmedicine.1342-22
   Takata T, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23169410
   Takata T, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22094374
   Takeda T, 2017, BBA-GEN SUBJECTS, V1861, P1813, DOI 10.1016/j.bbagen.2017.03.018
   Takeda TA, 2015, SCI REP-UK, V5, DOI 10.1038/srep10488
   Uchida A, 2019, NEPHROLOGY, V24, P28, DOI 10.1111/nep.13189
   Yamamoto T, 2017, J AM SOC NEPHROL, V28, P1534, DOI 10.1681/ASN.2016070731
   Yang X, 2015, INT J MOL SCI, V16, P25865, DOI 10.3390/ijms161025865
   Zenke-Kawasaki Y, 2007, MOL CELL BIOL, V27, P6962, DOI 10.1128/MCB.02415-06
   Zhang Y, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0916-0
NR 46
TC 6
Z9 6
U1 2
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN
PY 2023
VL 24
IS 12
AR 10151
DI 10.3390/ijms241210151
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA K2TM1
UT WOS:001015015100001
PM 37373300
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Aydogdu, A
   Karakas, EY
   Erkus, E
   Altiparmak, IH
   Savik, E
   Ulas, T
   Sabuncu, T
AF Aydogdu, Ali
   Karakas, Emel Yigit
   Erkus, Emre
   Altiparmak, Ibrahim Halil
   Savik, Emin
   Ulas, Turgay
   Sabuncu, Tevfik
TI Epicardial fat thickness and oxidative stress parameters in patients
   with subclinical hypothyroidism
SO ARCHIVES OF MEDICAL SCIENCE
LA English
DT Article
DE epicardial fat thickness; oxidative stress; subclinical hypothyroidism
ID ADIPOSE-TISSUE; LIPID-PEROXIDATION; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; THYROID-FUNCTION; OVERT; SERUM; ASSOCIATION; OBESITY; LEVEL
AB Introduction: Thyroid disorders are known to be a risk factor for cardiovascular diseases. Epicardial fat thickness (EFT) and oxidative stress are also believed to be major risk factors for cardiovascular events. The aim of this study was to evaluate the possible relationship between oxidative stress parameters and EFT in patients with subclinical hypothyroidism (SCH).
   Material and methods: A total of 60 individuals (30 patients with SCH and 30 healthy controls) were recruited for the study. The EFT and oxidative stress parameters of all participants were analyzed at baseline; the same were analyzed in SCH patients after achievement of a euthyroid state.
   Results: Compared to healthy subjects, SCH patients had significantly higher EFT and oxidative stress parameters (p < 0.05 for all). EFT and oxidative stress parameters both decreased after treatment, but only the decrease of EFT levels was statistically significant after thyroid hormone replacement (p < 0.05). Serum EFT levels were not significantly correlated with oxidative stress index (r = 0.141, p = 0.458).
   Conclusions: Previous studies have demonstrated that visceral adipose tissue and oxidative stress are major risk factors for cardiovascular events; our study demonstrated that EFT, a visceral adipose tissue, and oxidative stress parameters were higher, and could be used as an indicator for cardiovascular diseases in patients with SCH.
C1 [Aydogdu, Ali; Karakas, Emel Yigit; Ulas, Turgay] Harran Univ, Dept Internal Med, Fac Med, Yenisehir Campus, TR-63300 Sanliurfa, Turkey.
   [Erkus, Emre; Altiparmak, Ibrahim Halil] Harran Univ, Dept Cardiol, Fac Med, Sanliurfa, Turkey.
   [Savik, Emin] Harran Univ, Dept Biochem, Fac Med, Sanliurfa, Turkey.
   [Sabuncu, Tevfik] Harran Univ, Dept Internal Med & Endocrinol, Fac Med, Sanliurfa, Turkey.
C3 Harran University; Harran University; Harran University; Harran
   University
RP Karakas, EY (corresponding author), Harran Univ, Dept Internal Med, Fac Med, Yenisehir Campus, TR-63300 Sanliurfa, Turkey.
EM e.ygtkarakas@yahoo.com.tr
RI Erkuş, Emre/ABC-4126-2021; altıparmak, ibrahim/ABF-4178-2020; Ulas,
   Turgay/A-6050-2018; Sabuncu, Tevfik/ABF-5291-2020
CR Aghili R, 2012, ARCH MED SCI, V8, P1096, DOI 10.5114/aoms.2012.32423
   Aronow WS, 2012, ARCH MED SCI, V8, P375, DOI 10.5114/aoms.2012.28568
   Asik M, 2013, CLIN ENDOCRINOL, V79, P571, DOI 10.1111/cen.12176
   Bianchi G, 1999, HORM METAB RES, V31, P620, DOI 10.1055/s-2007-978808
   Biondi B, 2008, ENDOCR REV, V29, P76, DOI 10.1210/er.2006-0043
   Cebeci Egemen, 2011, Acta Biomed, V82, P214
   Costantini F, 1998, ARTERIOSCL THROM VAS, V18, P732, DOI 10.1161/01.ATV.18.5.732
   Dumitriu L, 1988, Endocrinologie, V26, P35
   Erdogan M, 2011, J ENDOCRINOL INVEST, V34, P488, DOI 10.3275/7202
   Erel O, 2004, CLIN BIOCHEM, V37, P112, DOI 10.1016/j.clinbiochem.2003.10.014
   Erel O, 2005, CLIN BIOCHEM, V38, P1103, DOI 10.1016/j.clinbiochem.2005.08.008
   Galili O, 2007, AM J PHYSIOL-HEART C, V292, pH904, DOI 10.1152/ajpheart.00628.2006
   Haribabu A, 2013, ENDOCRINE, V44, P152, DOI 10.1007/s12020-012-9849-y
   Iacobellis G, 2003, J CLIN ENDOCR METAB, V88, P5163, DOI 10.1210/jc.2003-030698
   Iacobellis G, 2003, OBES RES, V11, P304, DOI 10.1038/oby.2003.45
   Iacobellis G, 2007, CURR PHARM DESIGN, V13, P2180
   Korkmaz L, 2013, MED PRIN PRACT, V22, P42, DOI 10.1159/000340065
   Lee Yeo Kyung, 2011, Korean Journal of Internal Medicine, V26, P432, DOI 10.3904/kjim.2011.26.4.432
   Lemieux S, 2001, CAN J APPL PHYSIOL, V26, P273, DOI 10.1139/h01-018
   Liao YL, 2004, DIABETES CARE, V27, P978, DOI 10.2337/diacare.27.4.978
   Lin YK, 2010, MED HYPOTHESES, V74, P1026, DOI 10.1016/j.mehy.2010.01.004
   Oziol L, 2003, J ENDOCRINOL, V177, P137, DOI 10.1677/joe.0.1770137
   Öztürk Ü, 2012, INT IMMUNOPHARMACOL, V14, P349, DOI 10.1016/j.intimp.2012.08.010
   PEREIRA B, 1994, J ENDOCRINOL, V140, P73, DOI 10.1677/joe.0.1400073
   Reddy VS, 2013, HORM METAB RES, V45, P754, DOI 10.1055/s-0033-1348262
   Sacks HS, 2011, METAB SYNDR RELAT D, V9, P433, DOI 10.1089/met.2011.0024
   Salgado-Somoza A, 2010, AM J PHYSIOL-HEART C, V299, pH202, DOI 10.1152/ajpheart.00120.2010
   Santi A, 2012, INT J ENDOCRINOL, V2012, DOI 10.1155/2012/856359
   Santos OC, 2015, J ENDOCRINOL INVEST, V38, P421, DOI 10.1007/s40618-014-0199-x
   So M, 2012, AUST FAM PHYSICIAN, V41, P556
   SWAROOP A, 1985, BIOCHEM J, V226, P403, DOI 10.1042/bj2260403
   Torun AN, 2009, CLIN ENDOCRINOL, V70, P469, DOI 10.1111/j.1365-2265.2008.03348.x
   Ulas T, 2013, INT J CARDIOL, V167, P1643, DOI 10.1016/j.ijcard.2012.11.027
   Ulas T, 2013, INT J CARDIOL, V164, P128, DOI 10.1016/j.ijcard.2012.06.077
   Ulas T, 2012, CLIN INVEST MED, V35, pE126
   Unubol M, 2014, MINERVA ENDOCRINOL, V39, P135
   Waring AC, 2012, CLIN ENDOCRINOL, V76, P911, DOI 10.1111/j.1365-2265.2011.04328.x
   Wilund KR, 2010, NEPHROL DIAL TRANSPL, V25, P2695, DOI 10.1093/ndt/gfq106
   Yilmaz S, 2003, CELL BIOCHEM FUNCT, V21, P325, DOI 10.1002/cbf.1031
NR 39
TC 15
Z9 16
U1 0
U2 4
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1734-1922
EI 1896-9151
J9 ARCH MED SCI
JI Arch. Med. Sci.
PD MAR
PY 2017
VL 13
IS 2
BP 383
EP 389
DI 10.5114/aoms.2017.65479
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EM5PW
UT WOS:000395365500014
PM 28261292
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Juvinao-Quintero, DL
   Larrabure-Torrealva, GT
   Sanchez, SE
   Kirschbaum, C
   Williams, MA
   Gelaye, B
AF Juvinao-Quintero, Diana L.
   Larrabure-Torrealva, Gloria T.
   Sanchez, Sixto E.
   Kirschbaum, Clemens
   Williams, Michelle A.
   Gelaye, Bizu
TI Maternal hair cortisol concentrations and its association with increased
   insulin resistance in midpregnancy
SO ANNALS OF EPIDEMIOLOGY
LA English
DT Article
DE Hair cortisol concentrations; Chronic stress; GDM; Fasting insulin; HOMA
   scores; Pregnancy
ID SALIVARY CORTISOL; GLUCOSE; DETERMINANTS; PREGNANCY; HYPERGLYCEMIA;
   HOMEOSTASIS; METABOLISM; PREDICTOR; SECRETION; DISEASE
AB Purpose: Stress and elevated maternal glycemia have negative effects on pregnancy. We evaluated the as-sociation of hair cortisol concentrations (HCC), a marker of chronic stress, with insulin resistance and ge-stational diabetes (GDM).Methods: In total, 527 women from Lima, Peru, provided a hair sample in the second trimester of their pregnancy to measure HCC using liquid chromatography-tandem mass spectrometry. Each 6 cm of hair captured HCC in early (T1=1-12 weeks) and midpregnancy (T2 = 13-24 weeks). GDM diagnosis was con-ducted in midpregnancy. Multivariable regression models adjusted for putative risk factorsincluding ma-ternal sociodemographic factors, diabetes history, and hair characteristics, were used to estimate the association of HCC with GDM and various glycemic traits.Results: GDM was diagnosed in 122 (23%) women. Mean HCC across pregnancy was T1 = 3.7 ( +/- 3.4) pg/mg and T2 = 4.8 ( +/- 3.4) pg/mg. HCC was associated with increased log-transformed units of fasting insulin (T1 = 0.15 [0.03, 0.27], T2 = 0.17 [0.04, 0.30]), homeostasis model assessment for insulin resistance (T1 = 0.14 [0.01, 0.26], T2 = 0.17 [0.03, 0.30]), and homeostasis model assessment for beta-cell function (T1 = 0.20 [0.05, 0.34], T2 = 0.20 [0.04, 0.36]), but not with GDM (T1 = 0.95 [0.63, 1.40], T2 = 1.11 [0.74, 1.67]).Conclusions: Elevated maternal HCC was associated with abnormal insulin homeostasis in pregnancy. Dysregulation of the hypothalamic-pituitary-adrenal axis, as reflected by high HCC, may also contribute to insulin resistance syndrome in pregnancy.(c) 2023 Elsevier Inc. All rights reserved.
C1 [Juvinao-Quintero, Diana L.; Williams, Michelle A.; Gelaye, Bizu] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
   [Larrabure-Torrealva, Gloria T.] Univ Nacl Mayor San Marcos, Dept Acad Med Humana, Lima, Peru.
   [Larrabure-Torrealva, Gloria T.] Inst Nacl Materno Perinatal, Lima, Peru.
   [Sanchez, Sixto E.] Univ San Martin Porres, Fac Med Humana, Inst Invest, Lima, Peru.
   [Kirschbaum, Clemens] Asociac Civil PROESA, Lima, Peru.
   [Gelaye, Bizu] Tech Univ Dresden, Dept Psychol, Dresden, Germany.
   [Gelaye, Bizu] Massachusetts Gen Hosp, Chester M Pierce MD Div Global Psychiat, Boston, MA USA.
   [Gelaye, Bizu] Harvard Med Sch, Ctr Bioeth, Boston, MA USA.
   [Juvinao-Quintero, Diana L.] 677 Huntington Ave Room 500, Boston, MA 02115 USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health;
   Universidad Nacional Mayor de San Marcos; Universidad de San Martin de
   Porres; Technische Universitat Dresden; Harvard University; Harvard
   University Medical Affiliates; Massachusetts General Hospital; Harvard
   University; Harvard Medical School
RP Juvinao-Quintero, DL (corresponding author), 677 Huntington Ave Room 500, Boston, MA 02115 USA.
EM djq@hsph.harvard.edu
RI Kirschbaum, Clemens/AAB-1752-2020; SANCHEZ, SIXTO/HTO-5928-2023;
   Juvinao-Quintero, Diana/HYU-1922-2023; Gelaye, Bizu/GSI-6520-2022
OI Sanchez, Sixto/0000-0003-0354-0523
FU Roche Diagnostic Operations Inc [208617-5074547]; National Institute of
   Health [R21 HD102822]
FX Funding This study was supported by Roche Diagnostic Operations Inc
   (project number 208617-5074547) and the National Institute of Health
   (R21 HD102822) . Sponsors had no role in study design; in the
   collection, analysis, and interpretation of data; in the writing of the
   manuscript.
CR Ahmed SAM, 1999, E AFR MED J, V76, P465
   Arumugam R, 2008, ENDOCRINOLOGY, V149, P5401, DOI 10.1210/en.2008-0051
   Barker DJP, 2007, J INTERN MED, V261, P412, DOI 10.1111/j.1365-2796.2007.01809.x
   Barrett ES, 2018, HUM REPROD, V33, P1757, DOI 10.1093/humrep/dey261
   Bleker LS, 2017, PSYCHONEUROENDOCRINO, V83, P172, DOI 10.1016/j.psyneuen.2017.05.026
   Bonora E, 2002, DIABETES CARE, V25, P1135, DOI 10.2337/diacare.25.7.1135
   Braig S, 2015, PSYCHONEUROENDOCRINO, V52, P289, DOI 10.1016/j.psyneuen.2014.12.006
   Caparros-Gonzalez RA, 2019, J CLIN MED, V8, DOI 10.3390/jcm8112015
   Chiodini I, 2007, DIABETES CARE, V30, P83, DOI 10.2337/dc06-1267
   D'Anna-Hernandez KL, 2011, PHYSIOL BEHAV, V104, P348, DOI 10.1016/j.physbeh.2011.02.041
   Duffy AR, 2018, BIOL RES NURS, V20, P292, DOI 10.1177/1099800418758952
   Duthie L, 2013, NEUROENDOCRINOLOGY, V98, P106, DOI 10.1159/000354702
   Feng Y, 2020, NUTR DIABETES, V10, DOI 10.1038/s41387-020-0107-8
   Gao W, 2013, J CHROMATOGR B, V928, P1, DOI 10.1016/j.jchromb.2013.03.008
   Gerber M, 2013, STRESS, V16, P593, DOI 10.3109/10253890.2013.823599
   Gibson EL, 1999, PSYCHOSOM MED, V61, P214, DOI 10.1097/00006842-199903000-00014
   Hackett RA, 2016, J CLIN ENDOCR METAB, V101, P619, DOI 10.1210/jc.2015-2853
   Horan H, 2022, AM J HUM BIOL, V34, DOI 10.1002/ajhb.23718
   Iob E, 2019, CURR CARDIOL REP, V21, DOI 10.1007/s11886-019-1208-7
   Joseph JJ, 2015, PSYCHONEUROENDOCRINO, V62, P327, DOI 10.1016/j.psyneuen.2015.08.021
   Kalra S, 2007, CLIN INVEST MED, V30, pE103, DOI 10.25011/cim.v30i2.986
   Kampmann U, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/5320156
   Keller-Wood M, 2014, AM J PHYSIOL-REG I, V307, pR405, DOI 10.1152/ajpregu.00530.2013
   Kirwan JP, 2002, DIABETES, V51, P2207, DOI 10.2337/diabetes.51.7.2207
   Kuo T, 2015, ADV EXP MED BIOL, V872, P99, DOI 10.1007/978-1-4939-2895-8_5
   Larrabure-Torrealva GT, 2018, BMC PREGNANCY CHILDB, V18, DOI 10.1186/s12884-018-1904-0
   Maimon L, 2020, ISCIENCE, V23, DOI 10.1016/j.isci.2020.101501
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   MENDELSON JH, 1966, PSYCHOSOM MED, V28, P616, DOI 10.1097/00006842-196607000-00037
   Metzger BE, 2010, DIABETES CARE, V33, P676, DOI 10.2337/dc09-1848
   Orta OR, 2019, STRESS, V22, P60, DOI 10.1080/10253890.2018.1504917
   Remer T, 2008, MINI-REV MED CHEM, V8, P153, DOI 10.2174/138955708783498096
   Spiga F, 2014, COMPR PHYSIOL, V4, P1273, DOI 10.1002/cphy.c140003
   Stalder T, 2017, PSYCHONEUROENDOCRINO, V77, P261, DOI 10.1016/j.psyneuen.2016.12.017
   Stalder T, 2012, BRAIN BEHAV IMMUN, V26, P1019, DOI 10.1016/j.bbi.2012.02.002
   Steptoe A, 2006, INT J PSYCHOPHYSIOL, V59, P228, DOI 10.1016/j.ijpsycho.2005.10.011
   Traylor CS, 2020, AM J OBST GYNEC MFM, V2, P1
   Ullrich S, 2005, DIABETES, V54, P1090, DOI 10.2337/diabetes.54.4.1090
   van Buuren S, 2011, J STAT SOFTW, V45, P1
   Vejrazkova D, 2014, J STEROID BIOCHEM, V139, P122, DOI 10.1016/j.jsbmb.2012.11.007
   Wennig R, 2000, FORENSIC SCI INT, V107, P5, DOI 10.1016/S0379-0738(99)00146-2
   Wright KD, 2015, GERONTOLOGIST, V55, pS140, DOI 10.1093/geront/gnu174
   Zhuang WZ, 2020, EXP THER MED, V20, P3361, DOI 10.3892/etm.2020.9050
NR 43
TC 2
Z9 3
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1047-2797
EI 1873-2585
J9 ANN EPIDEMIOL
JI Ann. Epidemiol.
PD MAY
PY 2023
VL 81
DI 10.1016/j.annepidem.2023.02.011
EA APR 2023
PG 18
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA F2AE8
UT WOS:000980416900001
PM 36841381
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Mezzetti, A
   Cipollone, F
   Cuccurullo, F
AF Mezzetti, A
   Cipollone, F
   Cuccurullo, F
TI Oxidative stress and cardiovascular complications in diabetes:
   isoprostanes as new markers on an old paradigm
SO CARDIOVASCULAR RESEARCH
LA English
DT Review
DE cholesterol; coronary disease; diabetes; free radicals; lipid metabolism
ID LOW-DENSITY-LIPOPROTEIN; PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-2;
   ENDOTHELIUM-DEPENDENT RELAXATION; HUMAN ATHEROSCLEROTIC LESIONS;
   INSULIN-RESISTANCE SYNDROME; TISSUE FACTOR EXPRESSION; VASCULAR
   SMOOTH-MUSCLE; HIGH-GLUCOSE MEDIUM; IN-VIVO FORMATION; OXIDANT STRESS
AB Long-term vascular complications still represent the main cause of morbidity and mortality in diabetic patients. Although randomized long-term clinical studies comparing the effects of conventional and intensive therapy have demonstrated a clear link between hyperglycemia and the development of complications of diabetes, they have not defined the mechanism through which excess glucose results in tissue damage. Evidence has accumulated indicating that oxidative stress may play a key role in the etiology of diabetic complications. Isoprostanes are emerging as a new class of biologically active products of arachidonic acid metabolism of potential relevance to human Vascular disease. Their formation in vivo seems to reflect primarily, if not exclusively, a nonenzymatic process of Lipid peroxidation. Enhanced urinary excretion of 8-iso-PGF(2 alpha) has been described in association with both type 1 and type 2 diabetes mellitus, and correlates with impaired glycemic control. Besides providing a likely noninvasive index of lipid peroxidation in this setting, measurements of specific F-2 isoprostanes in urine may provide a sensitive biochemical end point for dose-finding studies of natural and synthetic inhibitors of lipid peroxidation. Although the biological effects of 8-iso-PGF(2 alpha) in vitro suggest that it and other isoeicosanoids may modulate the functional consequences of lipid peroxidation in diabetes, evidence that this is likely in vivo remains inadequate at this time. (C) 2000 Elsevier Science B.V. All rights reserved.
C1 Univ G DAnnunzio, Sch Med, Dept Med & Aging, Chieti, Italy.
C3 G d'Annunzio University of Chieti-Pescara
RP Nuovo Policlin SS Annunziata, Ctr Prevenz Aterosclerosi Diagnosi & Terapia Iper, Via Vestini 66, I-66013 Chieti, Italy.
EM mezzetti@unich.it
RI Cipollone, Francesco/AAC-5698-2022
OI Cipollone, Francesco/0000-0002-5993-9341
CR Abraira C, 1997, ARCH INTERN MED, V157, P181, DOI 10.1001/archinte.157.2.181
   ASAHINA T, 1995, DIABETES, V44, P520, DOI 10.2337/diabetes.44.5.520
   AUDOLY L, IN PRESS CIRCULATION
   AWAD JA, 1993, J BIOL CHEM, V268, P4161
   BAYNES JW, 1991, DIABETES, V40, P405, DOI 10.2337/diabetes.40.4.405
   Berliner JA, 1996, FREE RADICAL BIO MED, V20, P707, DOI 10.1016/0891-5849(95)02173-6
   BIERMAN EL, 1992, ARTERIOSCLER THROMB, V12, P647, DOI 10.1161/01.ATV.12.6.647
   BROWNLEE M, 1995, ANNU REV MED, V46, P223, DOI 10.1146/annurev.med.46.1.223
   Cameron NE, 1997, DIABETES, V46, pS31, DOI 10.2337/diab.46.2.S31
   CAMERON NE, 1994, DIABETES METAB REV, V10, P189, DOI 10.1002/dmr.5610100302
   CatellaLawson F, 1996, J INVEST MED, V44, pA223
   Ceriello A, 2000, METABOLISM, V49, P27, DOI 10.1016/S0026-0495(00)80082-7
   Chisholm DJ, 1997, CLIN EXP PHARMACOL P, V24, P782, DOI 10.1111/j.1440-1681.1997.tb02132.x
   CHISOLM GM, 1992, DIABETES, V41, P61, DOI 10.2337/diab.41.2.S61
   CIABATTONI G, IN PRESS AM J RESPIR
   CIPOLLONE F, IN PRESS CIRCULATION
   DAVI G, 1990, NEW ENGL J MED, V322, P1769, DOI 10.1056/NEJM199006213222503
   Davì G, 1999, CIRCULATION, V99, P224
   Davi G, 1997, ARTERIOSCL THROM VAS, V17, P3230, DOI 10.1161/01.ATV.17.11.3230
   Dechenes CJ, 1998, AM J PHYSIOL-ENDOC M, V275, pE785, DOI 10.1152/ajpendo.1998.275.5.E785
   DEGENHARDT TP, 1998, MAILLARD REACTION FO, P3
   Delanty N, 1997, CIRCULATION, V95, P2492, DOI 10.1161/01.CIR.95.11.2492
   Ferro D, 1999, BLOOD, V93, P2945
   FITZGERALD DJ, 1989, P NATL ACAD SCI USA, V86, P7585, DOI 10.1073/pnas.86.19.7585
   FONTBONNE A, 1991, DIABETOLOGIA, V34, P356, DOI 10.1007/BF00405009
   FUKUNAGA M, 1993, AM J PHYSIOL, V264, pC1619, DOI 10.1152/ajpcell.1993.264.6.C1619
   Gerich JE, 1998, ENDOCR REV, V19, P491, DOI 10.1210/edrv.19.4.0338
   Giugliano D, 1996, DIABETES CARE, V19, P257, DOI 10.2337/diacare.19.3.257
   Gniwotta C, 1997, ARTERIOSCL THROM VAS, V17, P3236, DOI 10.1161/01.ATV.17.11.3236
   GOPAUL NK, 1994, BIOCHEM BIOPH RES CO, V200, P338, DOI 10.1006/bbrc.1994.1453
   GOPAUL NK, 1995, FEBS LETT, V368, P225, DOI 10.1016/0014-5793(95)00649-T
   Gray RS, 1998, AM J EPIDEMIOL, V148, P869
   HANGAISHI M, 1997, CIRCULATION S1, V96, P665
   HARRISON KA, 1995, J BIOL CHEM, V270, P17273, DOI 10.1074/jbc.270.29.17273
   HOHMAN TC, 1994, EXPERT OPIN INV DRUG, V3, P1041
   Hopkins PN, 1996, CURR OPIN LIPIDOL, V7, P241, DOI 10.1097/00041433-199608000-00011
   HOTTA N, 1995, BIOMED PHARMACOTHER, V49, P232, DOI 10.1016/0753-3322(96)82629-1
   Hou X, 2000, STROKE, V31, P516, DOI 10.1161/01.STR.31.2.516
   Humphriss DB, 1997, DIABETOLOGIA, V40, P1185, DOI 10.1007/s001250050805
   Ido Y, 1997, DIABETOLOGIA, V40, pS115, DOI 10.1007/s001250051422
   Ishii H, 1998, J MOL MED, V76, P21, DOI 10.1007/s109-1998-8101-y
   ISLAM KN, 1995, J BIOCHEM-TOKYO, V118, P1054, DOI 10.1093/jb/118.5.1054
   JHA P, 1995, ANN INTERN MED, V123, P860, DOI 10.7326/0003-4819-123-11-199512010-00009
   KAMATA K, 1989, BRIT J PHARMACOL, V97, P614, DOI 10.1111/j.1476-5381.1989.tb11993.x
   KASHIWAGI A, 1994, DIABETOLOGIA, V37, P264, DOI 10.1007/s001250050104
   Keaney J.F., 1994, Natural antioxidants in human health and disease, P303
   Khechai F, 1997, ARTERIOSCL THROM VAS, V17, P2885, DOI 10.1161/01.ATV.17.11.2885
   Kinsella BT, 1997, J PHARMACOL EXP THER, V281, P957
   KUNAPU P, 1998, J BIOL CHEM, V28, P22442
   Kunapuli P, 1997, J BIOL CHEM, V272, P27147, DOI 10.1074/jbc.272.43.27147
   Laight DW, 1999, EUR J PHARMACOL, V377, P89, DOI 10.1016/S0014-2999(99)00407-0
   Lawson JA, 1999, J BIOL CHEM, V274, P24441, DOI 10.1074/jbc.274.35.24441
   Lopes-Virella MF, 1997, DIABETES REV, V5, P410
   LOW PA, 1988, P NATL ACAD SCI USA, V81, P6894
   Lund DD, 2000, CIRCULATION, V101, P1027, DOI 10.1161/01.CIR.101.9.1027
   LYNCH SM, 1994, J CLIN INVEST, V93, P998, DOI 10.1172/JCI117107
   Lyons TJ, 1997, DIABETES REV, V5, P365
   Maillard LC, 1912, CR HEBD ACAD SCI, V154, P66
   Mallat Z, 1999, J CLIN INVEST, V103, P421, DOI 10.1172/JCI3985
   MALMBERG K, 1995, J AM COLL CARDIOL, V26, P57, DOI 10.1016/0735-1097(95)00126-K
   MCCANCE DR, 1993, J CLIN INVEST, V91, P2470, DOI 10.1172/JCI116482
   MCCORD JM, 1985, NEW ENGL J MED, V312, P159
   MERAJI S, 1987, DIABETES, V36, P978, DOI 10.2337/diabetes.36.8.978
   Mezzetti A, 1999, ARTERIOSCL THROM VAS, V19, P2659, DOI 10.1161/01.ATV.19.11.2659
   MORROW JD, 1995, NEW ENGL J MED, V332, P1198, DOI 10.1056/NEJM199505043321804
   MORROW JD, 1990, P NATL ACAD SCI USA, V87, P9383, DOI 10.1073/pnas.87.23.9383
   MORROW JD, 1994, J BIOL CHEM, V269, P4317
   MORROW JD, 1992, PROSTAGLANDINS, V44, P155, DOI 10.1016/0090-6980(92)90077-7
   MOSS SE, 1994, ARCH INTERN MED, V154, P2473
   Muller DC, 1996, SEMIN NEPHROL, V16, P289
   Nathan DM, 1996, ANN INTERN MED, V124, P86, DOI 10.7326/0003-4819-124-1_Part_2-199601011-00002
   NISHIGAKI I, 1981, BIOCHEM MED METAB B, V25, P373, DOI 10.1016/0006-2944(81)90096-X
   NOUROOZZADEH J, 1995, DIABETES, V44, P1054, DOI 10.2337/diabetes.44.9.1054
   Palinski W., 1996, NEW HORIZONS DIABETE, P81
   PANARA MR, 1995, BRIT J PHARMACOL, V116, P2429, DOI 10.1111/j.1476-5381.1995.tb15091.x
   Patrignani P, 1996, BRIT J PHARMACOL, V118, P1285, DOI 10.1111/j.1476-5381.1996.tb15535.x
   PATRIGNANI P, IN PRESS CIRCULATION
   PATRONO C, 1992, TRENDS CARDIOVAS MED, V2, P15, DOI 10.1016/1050-1738(92)90039-U
   PFEIFFER A, 1995, EXP CLIN ENDOCR DIAB, V103, P7, DOI 10.1055/s-0029-1211323
   PIEPER GM, 1995, DIABETES, V44, P884, DOI 10.2337/diabetes.44.8.884
   PIMENTA W, 1995, JAMA-J AM MED ASSOC, V273, P1855, DOI 10.1001/jama.273.23.1855
   Praticò D, 1998, P NATL ACAD SCI USA, V95, P3449, DOI 10.1073/pnas.95.7.3449
   Pratico D, 1997, J CLIN INVEST, V100, P2028, DOI 10.1172/JCI119735
   Praticò D, 1998, AM J RESP CRIT CARE, V158, P1709, DOI 10.1164/ajrccm.158.6.9709066
   PRATICO D, 1995, J BIOL CHEM, V270, P9800, DOI 10.1074/jbc.270.17.9800
   Pratico D, 1996, J BIOL CHEM, V271, P14916, DOI 10.1074/jbc.271.25.14916
   Pratico D, 1996, J BIOL CHEM, V271, P8919, DOI 10.1074/jbc.271.15.8919
   Praticò D, 1998, NAT MED, V4, P1189, DOI 10.1038/2685
   PYORALA K, 1987, Diabetes Metabolism Reviews, V3, P463
   Rajagopalan S, 1996, J CLIN INVEST, V97, P1916, DOI 10.1172/JCI118623
   Reckelhoff JF, 1998, AM J PHYSIOL-REG I, V274, pR767, DOI 10.1152/ajpregu.1998.274.3.R767
   Reilly M, 1996, CIRCULATION, V94, P19, DOI 10.1161/01.CIR.94.1.19
   Reilly MP, 1998, CIRCULATION, V98, P2822, DOI 10.1161/01.CIR.98.25.2822
   Reilly MP, 1997, CIRCULATION, V96, P3314
   Roberts LJ, 1997, BBA-LIPID LIPID MET, V1345, P121, DOI 10.1016/S0005-2760(96)00162-2
   Rokach J, 1997, PROSTAG OTH LIPID M, V54, P853, DOI 10.1016/S0090-6980(97)00184-6
   Rokach J, 1997, PROSTAG OTH LIPID M, V54, P823, DOI 10.1016/S0090-6980(97)00183-4
   SALVEMINI D, 1989, BRIT J PHARMACOL, V97, P1145, DOI 10.1111/j.1476-5381.1989.tb12572.x
   Sharma K, 1997, SEMIN NEPHROL, V17, P80
   SINGER DE, 1992, DIABETES, V41, P202, DOI 10.2337/diabetes.41.2.202
   SMITH WL, 1986, ANNU REV PHYSIOL, V48, P251
   Smith WL, 1996, J BIOL CHEM, V271, P33157, DOI 10.1074/jbc.271.52.33157
   STEINBERG D, 1989, NEW ENGL J MED, V320, P915
   Steinberg D, 1997, J BIOL CHEM, V272, P20963, DOI 10.1074/jbc.272.34.20963
   Stephens NG, 1996, LANCET, V347, P781, DOI 10.1016/S0140-6736(96)90866-1
   TAKAHASHI K, 1992, J CLIN INVEST, V90, P136, DOI 10.1172/JCI115826
   TSAI EC, 1994, DIABETES, V43, P1010, DOI 10.2337/diabetes.43.8.1010
   Turner RC, 1998, LANCET, V352, P837, DOI 10.1016/s0140-6736(98)07019-6
   Valagussa F, 1999, LANCET, V354, P447, DOI 10.1016/S0140-6736(99)07072-5
   VANDAM PS, 1995, DIABETES METAB REV, V11, P181, DOI 10.1002/dmr.5610110303
   Vlassara H, 1997, DIABETES, V46, pS19, DOI 10.2337/diab.46.2.S19
   WANG ZY, 1995, J PHARMACOL EXP THER, V275, P94
   WILLIAMSON JR, 1993, DIABETES, V42, P801, DOI 10.2337/diabetes.42.6.801
   Witztum JL, 1997, DIABETES, V46, pS112, DOI 10.2337/diab.46.2.S112
   Witztum JL, 1998, CIRCULATION, V98, P2785, DOI 10.1161/01.CIR.98.25.2785
   WITZTUM JL, 1991, J CLIN INVEST, V88, P1785, DOI 10.1172/JCI115499
   WOLFF SP, 1987, BIOCHEM J, V245, P243, DOI 10.1042/bj2450243
   YAN SD, 1994, J BIOL CHEM, V269, P9889
   YOSHIDA K, 1995, DIABETOLOGIA, V38, P201, DOI 10.1007/BF00400095
   Yusuf S, 2000, NEW ENGL J MED, V342, P154, DOI 10.1056/NEJM200001203420302
NR 120
TC 130
Z9 156
U1 0
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0008-6363
EI 1755-3245
J9 CARDIOVASC RES
JI Cardiovasc. Res.
PD AUG
PY 2000
VL 47
IS 3
BP 475
EP 488
DI 10.1016/S0008-6363(00)00118-8
PG 14
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 349QE
UT WOS:000089056500009
PM 10963721
OA Bronze
DA 2025-06-11
ER

PT J
AU Razavi, R
   Parvaresh, A
   Abbasi, B
   Yaghoobloo, K
   Hassanzadeh, A
   Mohammadifard, N
   Clark, CCT
   Safavi, SM
AF Razavi, Roghaye
   Parvaresh, Arefe
   Abbasi, Behnood
   Yaghoobloo, Khadijeh
   Hassanzadeh, Akbar
   Mohammadifard, Noushin
   Clark, Cain C. T.
   Safavi, Sayyed Morteza
TI The alternate-day fasting diet is a more effective approach than a
   calorie restriction diet on weight loss and hs-CRP levels
SO INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
LA English
DT Article
DE Alternate-day fasting diet; energy restriction; inflammation; metabolic
   syndrome
ID METABOLIC SYNDROME; ENERGY-EXPENDITURE; OXIDATIVE STRESS;
   BODY-COMPOSITION; FAT DIET; OVERWEIGHT; IMPROVEMENTS; INFLAMMATION;
   BIOMARKERS; ADHERENCE
AB Background and Objective: The aim of present study was to compare, and determine, the effects of a modified alternate-day fasting diet vs. calorie restriction on inflammatory indices and coagulation factors. Methods: This was a randomized clinical trial consisting of 80 metabolic syndrome patients, who were enrolled and randomly dichotomized into a modified alternate-day fasting diet or calorie restriction group for 4 months. We measured weight, body mass index (BMI), waist circumstance (WC), waist-hip-ratio (WHR) and fat mass as primary outcomes and assessed high sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha) and coagulation factors levels as secondary outcomes before and after intervention. Results: Compared to the calorie restriction diet, following a modified alternate-day fasting diet led to a greater reduction in body weight (kg) (-6.43 +/- 4.34 vs -4.11 +/- 4.27; P = 0.02), BMI (kg/m(2)) (-3.19 +/- 2.90 vs -1.43 +/- 2.72; P = 0.01), fat mass (kg) (-4.88 +/- 2.09 vs -3.72 +/- 2.43; P = 0.03), WC (cm) (-5.57 +/- 5.64 vs -2.32 +/- 5.95; P = 0.01) and WHR (-0.05 +/- 0.06 vs -0.02 +/- 0.07; P = 0.04). Furthermore, a greater change was found in hs-CRP levels (mg/L) (-2.06 +/- 1.18 vs -0.97 +/- 0.82; P = 0.03), prothrombin time (s) (1.41 +/- 2.34 vs -0.41 +/- 2.17; P < 0.001), activated partial thromboplastin time (s) (0.26 +/- 3.70 vs -1.78 +/- 3.56; P = 0.04) in modified alternate-day fasting diet when compared to calorie restriction diet. However, there was no difference in TNF-alpha or IL-6 and fibrinogen between groups (P > 0.05). Conclusions: These findings suggest that a modified alternate-day fasting diet can be a beneficial alternative for the management of body weight, fat mass and WC as well as hs-CRP and coagulation factors levels among metabolic syndrome patients.
C1 [Razavi, Roghaye; Parvaresh, Arefe; Yaghoobloo, Khadijeh; Safavi, Sayyed Morteza] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Esfahan, Iran.
   [Abbasi, Behnood] Islamic Azad Univ, Dept Nutr, Sci & Res Branch, Nutr, Tehran, Iran.
   [Hassanzadeh, Akbar] Isfahan Univ Med Sci, Sch Hlth, Dept Epidemiol & Biostat, Esfahan, Iran.
   [Mohammadifard, Noushin] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Ctr, Cardiovasc Res Inst, Esfahan, Iran.
   [Clark, Cain C. T.] Coventry Univ, Fac Res Ctr Sport Exercise & Life Sci, Coventry, W Midlands, England.
C3 Isfahan University of Medical Sciences; Islamic Azad University; Isfahan
   University of Medical Sciences; Isfahan University of Medical Sciences;
   Coventry University
RP Safavi, SM (corresponding author), Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Esfahan, Iran.
EM safavimorteza@yahoo.com
RI safavi, sayyed morteza/GLT-2139-2022; Clark, Cain/I-4480-2019; Abbasi,
   Behnood/K-6261-2018; Merat, Shahin/A-5478-2009; Abbasi,
   Behnood/H-1083-2016
OI Clark, Dr. Cain/0000-0002-6610-4617; Abbasi,
   Behnood/0000-0002-7684-3691; Razavi, Roghayeh/0000-0002-7081-4945
CR Adrie C, 2000, AM J PHYSIOL-CELL PH, V279, pC452, DOI 10.1152/ajpcell.2000.279.2.C452
   Al-Numair K., 2006, Journal of Medical Sciences (Pakistan), V6, P112
   Aziz CBA, 2014, N AM J MED SCI, V6, P377, DOI 10.4103/1947-2714.139286
   Belza A, 2009, INT J OBESITY, V33, P456, DOI 10.1038/ijo.2009.27
   Bhutani S, 2010, OBESITY, V18, P2152, DOI 10.1038/oby.2010.54
   Bladbjerg EM, 2014, THROMB RES, V133, P327, DOI 10.1016/j.thromres.2013.12.010
   Castello L, 2010, FREE RADICAL BIO MED, V48, P47, DOI 10.1016/j.freeradbiomed.2009.10.003
   Chae JS, 2013, NUTR RES, V33, P195, DOI 10.1016/j.nutres.2013.01.005
   Das SK, 2007, AM J CLIN NUTR, V85, P1023, DOI 10.1093/ajcn/85.4.1023
   Del Corral P, 2009, J CLIN ENDOCR METAB, V94, P1602, DOI 10.1210/jc.2008-1057
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Escrivá F, 2007, J ENDOCRINOL, V194, P131, DOI 10.1677/joe.1.07043
   Eshghinia S, 2013, J DIABETES METAB DIS, V12, DOI 10.1186/2251-6581-12-4
   Esmaillzadeh A, 2006, OBESITY, V14, P377, DOI 10.1038/oby.2006.50
   Fffff K.F., 2010, FFFBMC MED, V8, DOI [10.1186/1741-7015-8-18ffff, DOI 10.1186/1741-7015-8-18FFFF]
   Golbidi S, 2017, CURR DIABETES REP, V17, DOI 10.1007/s11892-017-0951-7
   Grundy SM, 2016, TRENDS CARDIOVAS MED, V26, P364, DOI 10.1016/j.tcm.2015.10.004
   Gu L, 2014, THROMB RES, V133, P993, DOI 10.1016/j.thromres.2014.01.001
   GUTTMAN SD, 1980, CELL, V22, P299, DOI 10.1016/0092-8674(80)90177-4
   Hakeam HA, 2009, OBES SURG, V19, P456, DOI 10.1007/s11695-008-9729-y
   Hoddy Kristin K, 2016, Nutr Healthy Aging, V4, P63, DOI 10.3233/NHA-1611
   Javandoost A, 2018, AVICENNA J PHYTOMEDI, V8, P330
   Johnson JB, 2007, FREE RADICAL BIO MED, V42, P665, DOI 10.1016/j.freeradbiomed.2006.12.005
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Krakauer Teresa, 2004, Current Drug Targets - Inflammation and Allergy, V3, P317
   Lam DW., 2000, Endotext
   Malik VS, 2007, NAT CLIN PRACT CARD, V4, P34, DOI 10.1038/ncpcardio0726
   MIFFLIN MD, 1990, AM J CLIN NUTR, V51, P241, DOI 10.1093/ajcn/51.2.241
   Moro T, 2016, J TRANSL MED, V14, DOI 10.1186/s12967-016-1044-0
   Morton JP, 2009, SPORTS MED, V39, P643, DOI 10.2165/00007256-200939080-00003
   Musaad S, 2007, EPIDEMIOL REV, V29, P98, DOI 10.1093/epirev/mxm005
   Redman LM, 2007, J CLIN ENDOCR METAB, V92, P865, DOI 10.1210/jc.2006-2184
   Rezaianzadeh A, 2012, INT J PREVENTIVE MED, V3, P552
   Shariatpanahi ZV, 2008, BRIT J NUTR, V100, P147, DOI 10.1017/S000711450787231X
   Varady KA, 2011, OBES REV, V12, pE593, DOI 10.1111/j.1467-789X.2011.00873.x
   Varady KA, 2007, AM J CLIN NUTR, V86, P7, DOI 10.1093/ajcn/86.1.7
   Varady KA, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-146
   Varady KA, 2010, J NUTR BIOCHEM, V21, P188, DOI 10.1016/j.jnutbio.2008.11.001
   Varady KA, 2009, AM J CLIN NUTR, V90, P1138, DOI 10.3945/ajcn.2009.28380
   Varady KA, 2009, METABOLISM, V58, P803, DOI 10.1016/j.metabol.2009.01.018
   Vasconcelos AR, 2014, J NEUROINFLAMM, V11, DOI 10.1186/1742-2094-11-85
   Weiss EP, 2007, J NUTR, V137, P1087, DOI 10.1093/jn/137.4.1087
   Yang WW, 2016, NUTR RES, V36, P586, DOI 10.1016/j.nutres.2016.02.001
NR 43
TC 42
Z9 43
U1 2
U2 7
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 0300-9831
EI 1664-2821
J9 INT J VITAM NUTR RES
JI Int. J. Vitam. Nutr. Res.
PD MAY
PY 2021
VL 91
IS 3-4
BP 242
EP 250
DI 10.1024/0300-9831/a000623
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA WY8NE
UT WOS:000719533200008
PM 32003649
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Posa, DK
   Baba, SP
AF Posa, Dheeraj Kumar
   Baba, Shahid P.
TI Intracellular pH Regulation of Skeletal Muscle in the Milieu of Insulin
   Signaling
SO NUTRIENTS
LA English
DT Review
DE carnosine; chronic kidney disease; diabetes; glycolysis; histidyl
   dipeptides; insulin signaling; intracellular pH; obesity
ID HIGH-FAT DIET; CHRONIC KIDNEY-DISEASE; LOW URINE PH; OXIDATIVE STRESS;
   HEXOKINASE-II; GENE-EXPRESSION; GLUCOSE-TOLERANCE; ATHEROSCLEROSIS RISK;
   PROTEIN-METABOLISM; LACTATE TRANSPORT
AB Type 2 diabetes (T2D), along with obesity, is one of the leading health problems in the world which causes other systemic diseases, such as cardiovascular diseases and kidney failure. Impairments in glycemic control and insulin resistance plays a pivotal role in the development of diabetes and its complications. Since skeletal muscle constitutes a significant tissue mass of the body, insulin resistance within the muscle is considered to initiate the onset of diet-induced metabolic syndrome. Insulin resistance is associated with impaired glucose uptake, resulting from defective post-receptor insulin responses, decreased glucose transport, impaired glucose phosphorylation, oxidation and glycogen synthesis in the muscle. Although defects in the insulin signaling pathway have been widely studied, the effects of cellular mechanisms activated during metabolic syndrome that cross-talk with insulin responses are not fully elucidated. Numerous reports suggest that pathways such as inflammation, lipid peroxidation products, acidosis and autophagy could cross-talk with insulin-signaling pathway and contribute to diminished insulin responses. Here, we review and discuss the literature about the defects in glycolytic pathway, shift in glucose utilization toward anaerobic glycolysis and change in intracellular pH [pH](i) within the skeletal muscle and their contribution towards insulin resistance. We will discuss whether the derangements in pathways, which maintain [pH](i) within the skeletal muscle, such as transporters (monocarboxylate transporters 1 and 4) and depletion of intracellular buffers, such as histidyl dipeptides, could lead to decrease in [pH](i) and the onset of insulin resistance. Further we will discuss, whether the changes in [pH](i) within the skeletal muscle of patients with T2D, could enhance the formation of protein aggregates and activate autophagy. Understanding the mechanisms by which changes in the glycolytic pathway and [pH](i) within the muscle, contribute to insulin resistance might help explain the onset of obesity-linked metabolic syndrome. Finally, we will conclude whether correcting the pathways which maintain [pH](i) within the skeletal muscle could, in turn, be effective to maintain or restore insulin responses during metabolic syndrome.
C1 [Posa, Dheeraj Kumar; Baba, Shahid P.] Univ Louisville, Diabet & Obes Ctr, Louisville, KY 40202 USA.
   [Posa, Dheeraj Kumar; Baba, Shahid P.] Univ Louisville, Christina Lee Brown Envirome Inst, Louisville, KY 40202 USA.
C3 University of Louisville; University of Louisville
RP Posa, DK (corresponding author), Univ Louisville, Diabet & Obes Ctr, Louisville, KY 40202 USA.; Posa, DK (corresponding author), Univ Louisville, Christina Lee Brown Envirome Inst, Louisville, KY 40202 USA.
EM dheerajkumar.posa@louisville.edu; spbaba01@louisville.edu
OI Posa, Dheeraj kumar/0000-0003-0762-0280
FU National Institutes of Health [R01HL122581-01]
FX This work was supported by the National Institutes of Health:
   R01HL122581-01 (SPB).
CR Abe H, 2000, BIOCHEMISTRY-MOSCOW+, V65, P757
   Aldini G, 2011, J CELL MOL MED, V15, P1339, DOI 10.1111/j.1582-4934.2010.01101.x
   Anderson EJ, 2018, J CLIN INVEST, V128, P5280, DOI 10.1172/JCI94307
   Avogaro A, 1996, J CLIN INVEST, V98, P108, DOI 10.1172/JCI118754
   Baba SP, 2013, J BIOL CHEM, V288, P28163, DOI 10.1074/jbc.M113.504753
   Bailey JL, 2006, J AM SOC NEPHROL, V17, P1388, DOI 10.1681/ASN.2004100842
   Baran EJ, 2000, BIOCHEMISTRY-MOSCOW+, V65, P789
   BECKERZIMMERMANN K, 1982, DIABETOLOGIA, V22, P468, DOI 10.1007/BF00282592
   Berezhnov AV, 2016, J BIOL CHEM, V291, P8701, DOI 10.1074/jbc.M115.691774
   Boldyrev AA, 2013, PHYSIOL REV, V93, P1803, DOI 10.1152/physrev.00039.2012
   Bonen A, 2000, MED SCI SPORT EXER, V32, P778, DOI 10.1097/00005768-200004000-00010
   Bonen A, 1998, AM J PHYSIOL-ENDOC M, V274, pE102, DOI 10.1152/ajpendo.1998.274.1.E102
   Bouché C, 2004, ENDOCR REV, V25, P807, DOI 10.1210/er.2003-0026
   Bouzakri K, 2005, CURR DIABETES REV, V1, P167, DOI 10.2174/1573399054022785
   Bruunsgaard H, 2005, J LEUKOCYTE BIOL, V78, P819, DOI 10.1189/jlb.0505247
   Cappellari GG, 2016, DIABETES, V65, P874, DOI 10.2337/db15-1019
   Chang PY, 1996, J BIOL CHEM, V271, P14834, DOI 10.1074/jbc.271.25.14834
   Chatel B, 2017, FASEB J, V31, P2562, DOI 10.1096/fj.201601259R
   Choi CS, 2002, AM J PHYSIOL-ENDOC M, V283, pE233, DOI 10.1152/ajpendo.00557.2001
   Christ CY, 2002, J APPL PHYSIOL, V92, P736, DOI 10.1152/japplphysiol.00784.2001
   Crawford SO, 2010, INT J EPIDEMIOL, V39, P1647, DOI 10.1093/ije/dyq126
   Culbertson JY, 2010, NUTRIENTS, V2, P75, DOI 10.3390/nu2010075
   Cusi KJ, 2001, METABOLISM, V50, P602, DOI 10.1053/meta.2001.22568
   CUTHBERT C, 1978, METABOLISM, V27, P1903, DOI 10.1016/S0026-0495(78)80008-0
   DAVEY CL, 1960, ARCH BIOCHEM BIOPHYS, V89, P303, DOI 10.1016/0003-9861(60)90059-X
   de Courten B, 2016, OBESITY, V24, P1027, DOI 10.1002/oby.21434
   DEFRONZO RA, 1979, AM J PHYSIOL, V236, pE328, DOI 10.1152/ajpendo.1979.236.4.E328
   DeFronzo RA, 2009, DIABETES CARE, V32, pS157, DOI 10.2337/dc09-S302
   Deivanayagam S, 2008, AM J CLIN NUTR, V88, P257, DOI 10.1093/ajcn/88.2.257
   Deutsch A, 1938, BIOCHEM J, V32, P209, DOI 10.1042/bj0320209
   Drozak J, 2010, J BIOL CHEM, V285, P9346, DOI 10.1074/jbc.M109.095505
   Dubouchaud H, 2000, AM J PHYSIOL-ENDOC M, V278, pE571, DOI 10.1152/ajpendo.2000.278.4.E571
   Dubouchaud H, 1996, J APPL PHYSIOL, V80, P416, DOI 10.1152/jappl.1996.80.2.416
   Ducluzeau PH, 2001, DIABETES, V50, P1134, DOI 10.2337/diabetes.50.5.1134
   DUNAWAY GA, 1988, BIOCHEM J, V251, P677, DOI 10.1042/bj2510677
   Everaert I, 2013, EUR J APPL PHYSIOL, V113, P1169, DOI 10.1007/s00421-012-2540-4
   Fagherazzi G, 2014, DIABETOLOGIA, V57, P313, DOI 10.1007/s00125-013-3100-0
   Farwell WR, 2008, DIABETIC MED, V25, P798, DOI 10.1111/j.1464-5491.2008.02471.x
   Franch HA, 2004, AM J PHYSIOL-RENAL, V287, pF700, DOI 10.1152/ajprenal.00440.2003
   Fueger PT, 2004, DIABETES, V53, P306, DOI 10.2337/diabetes.53.2.306
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Garibotto G, 2015, KIDNEY INT, V88, P1419, DOI 10.1038/ki.2015.247
   Gatica D, 2018, NAT CELL BIOL, V20, P233, DOI 10.1038/s41556-018-0037-z
   Goodpaster BH, 2014, DIABETES, V63, P1058, DOI 10.2337/db13-1249
   Gualano B, 2012, AMINO ACIDS, V43, P21, DOI 10.1007/s00726-011-1165-y
   Halestrap AP, 1999, BIOCHEM J, V343, P281, DOI 10.1042/0264-6021:3430281
   Halestrap AP, 2004, PFLUG ARCH EUR J PHY, V447, P619, DOI 10.1007/s00424-003-1067-2
   HARDING JW, 1979, BRAIN RES, V173, P99, DOI 10.1016/0006-8993(79)91099-0
   Hayata H, 2014, BIOCHEM BIOPH RES CO, V445, P170, DOI 10.1016/j.bbrc.2014.01.162
   He CC, 2012, NATURE, V481, P511, DOI 10.1038/nature10758
   Heikkinen S, 1999, J BIOL CHEM, V274, P22517, DOI 10.1074/jbc.274.32.22517
   Hevener AL, 2000, DIABETES, V49, P2154, DOI 10.2337/diabetes.49.12.2154
   Hoetker D, 2018, J APPL PHYSIOL, V125, P1767, DOI 10.1152/japplphysiol.00007.2018
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Ihara H, 2019, J BIOL CHEM, V294, P1279, DOI 10.1074/jbc.RA118.006111
   Ingram KH, 2012, J CLIN ENDOCR METAB, V97, pE1182, DOI 10.1210/jc.2011-2963
   Juel C, 2008, ACTA PHYSIOL, V193, P17, DOI 10.1111/j.1748-1716.2008.01840.x
   Juel C, 2004, J PHYSIOL-LONDON, V556, P297, DOI 10.1113/jphysiol.2003.058222
   Juel C, 1999, J PHYSIOL-LONDON, V517, P633, DOI 10.1111/j.1469-7793.1999.0633s.x
   Juel C, 1997, PHYSIOL REV, V77, P321, DOI 10.1152/physrev.1997.77.2.321
   Juel C, 1998, ACTA PHYSIOL SCAND, V162, P359, DOI 10.1046/j.1365-201X.1998.0305f.x
   Juraschek SP, 2013, ANN EPIDEMIOL, V23, P791, DOI 10.1016/j.annepidem.2013.09.005
   Keildson S, 2014, DIABETES, V63, P1154, DOI 10.2337/db13-1301
   Kiefte-de Jong JC, 2017, DIABETOLOGIA, V60, P270, DOI 10.1007/s00125-016-4153-7
   Kim KH, 2013, NAT MED, V19, P83, DOI 10.1038/nm.3014
   Kobayashi S, 2005, AM J KIDNEY DIS, V45, P275, DOI 10.1053/j.ajkd.2004.09.034
   Kristensen JM, 2004, ACTA PHYSIOL SCAND, V182, P69, DOI 10.1111/j.1365-201X.2004.01297.x
   Krook A, 2000, DIABETES, V49, P284, DOI 10.2337/diabetes.49.2.284
   Lengacher S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0082505
   LILLIOJA S, 1988, NEW ENGL J MED, V318, P1217, DOI 10.1056/NEJM198805123181901
   Liu M, 2007, P NATL ACAD SCI USA, V104, P371, DOI 10.1073/pnas.0609870104
   Liu Y, 2015, DIABETES, V64, P36, DOI 10.2337/db14-0267
   Maalouf NM, 2007, CLIN J AM SOC NEPHRO, V2, P883, DOI 10.2215/CJN.00670207
   Maalouf NM, 2010, CLIN J AM SOC NEPHRO, V5, P1277, DOI 10.2215/CJN.08331109
   Maddux BA, 2001, DIABETES, V50, P404, DOI 10.2337/diabetes.50.2.404
   Mak RHK, 1998, KIDNEY INT, V54, P603, DOI 10.1046/j.1523-1755.1998.00023.x
   MANNION AF, 1992, EUR J APPL PHYSIOL O, V64, P47, DOI 10.1007/BF00376439
   MAY RC, 1987, J CLIN INVEST, V79, P1099, DOI 10.1172/JCI112924
   MELDRUM N. IT., 1933, JOUR PHYSIOL, V80, P113
   Menini S, 2012, BRIT J PHARMACOL, V166, P1344, DOI 10.1111/j.1476-5381.2012.01834.x
   Metz L, 2005, BIOCHEM BIOPH RES CO, V331, P1338, DOI 10.1016/j.bbrc.2005.04.054
   Moller AB, 2017, SCI REP-UK, V7, DOI 10.1038/srep43775
   Monazzami A, 2017, CELL MOL BIOL, V63, P11, DOI 10.14715/cmb/2017.63.5.3
   Mong MC, 2011, EUR J PHARMACOL, V653, P82, DOI 10.1016/j.ejphar.2010.12.001
   Mullen E, 2010, INT J MOL MED, V25, P445, DOI 10.3892/ijmm_00000364
   Nerpin E, 2008, DIABETES CARE, V31, P1550, DOI 10.2337/dc08-0369
   NG RH, 1977, J NEUROCHEM, V28, P449, DOI 10.1111/j.1471-4159.1977.tb07770.x
   Nichols RC, 1996, AM J HUM GENET, V59, P59
   Nikooie R, 2013, J PHYSIOL BIOCHEM, V69, P865, DOI 10.1007/s13105-013-0263-6
   Orioli M, 2011, CHEMMEDCHEM, V6, P1269, DOI 10.1002/cmdc.201100042
   Pedersen BK, 2001, J PHYSIOL-LONDON, V536, P329, DOI 10.1111/j.1469-7793.2001.0329c.xd
   Perreault M, 2001, NAT MED, V7, P1138, DOI 10.1038/nm1001-1138
   Petersen MC, 2018, PHYSIOL REV, V98, P2133, DOI 10.1152/physrev.00063.2017
   Pette D, 2000, MICROSC RES TECHNIQ, V50, P500, DOI 10.1002/1097-0029(20000915)50:6<500::AID-JEMT7>3.3.CO;2-Z
   Pilegaard H, 1999, AM J PHYSIOL-ENDOC M, V276, pE843, DOI 10.1152/ajpendo.1999.276.5.E843
   Pilegaard H, 1998, SCAND J MED SCI SPOR, V8, P98
   Pilegaard H, 1999, AM J PHYSIOL-ENDOC M, V276, pE255, DOI 10.1152/ajpendo.1999.276.2.E255
   Rahimi Y, 2014, P NATL ACAD SCI USA, V111, P16508, DOI 10.1073/pnas.1419104111
   REAVEN GM, 1988, DIABETES, V37, P1020, DOI 10.2337/diabetes.37.8.1020
   Regazzoni L, 2016, SCI REP-UK, V6, DOI 10.1038/srep27224
   Ristow M, 1997, J CLIN INVEST, V100, P2833, DOI 10.1172/JCI119831
   Rudich A, 1999, DIABETOLOGIA, V42, P949, DOI 10.1007/s001250051253
   Rudich A, 1998, DIABETES, V47, P1562, DOI 10.2337/diabetes.47.10.1562
   Sauerhöfer S, 2007, DIABETES, V56, P2425, DOI 10.2337/db07-0177
   Scheuermann-Freestone M, 2003, CIRCULATION, V107, P3040, DOI 10.1161/01.CIR.0000072789.89096.10
   Schiaffino S, 2011, PHYSIOL REV, V91, P1447, DOI 10.1152/physrev.00031.2010
   Shulman GI, 2014, NEW ENGL J MED, V371, P1131, DOI 10.1056/NEJMra1011035
   Souto G, 2011, METAB SYNDR RELAT D, V9, P247, DOI 10.1089/met.2010.0108
   Stump CS, 2006, ANN MED, V38, P389, DOI 10.1080/07853890600888413
   TANOKURA M, 1976, BIOPOLYMERS, V15, P393, DOI 10.1002/bip.1976.360150215
   Teufel M, 2003, J BIOL CHEM, V278, P6521, DOI 10.1074/jbc.M209764200
   TRIVEDI B, 1966, J BIOL CHEM, V241, P4110
   Urakawa H, 2003, J CLIN ENDOCR METAB, V88, P4673, DOI 10.1210/jc.2003-030202
   Vestergaard H, 1995, J CLIN INVEST, V96, P2639, DOI 10.1172/JCI118329
   WARRAM JH, 1990, ANN INTERN MED, V113, P909, DOI 10.7326/0003-4819-113-12-909
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Wetzel P., CARBONIC ANHYDRASES, P375
   Wilson MC, 1998, J BIOL CHEM, V273, P15920, DOI 10.1074/jbc.273.26.15920
   Wu PF, 1999, DIABETES, V48, P1593, DOI 10.2337/diabetes.48.8.1593
   Xu H, 2014, DIABETOLOGIA, V57, P1561, DOI 10.1007/s00125-014-3275-z
   Yamada T, 2010, AM J PHYSIOL-ENDOC M, V299, pE364, DOI 10.1152/ajpendo.00142.2010
   Yang L, 2020, BIOLOGY-BASEL, V9, DOI 10.3390/biology9080203
NR 122
TC 13
Z9 14
U1 0
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2020
VL 12
IS 10
AR 2910
DI 10.3390/nu12102910
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OM6RK
UT WOS:000586149100001
PM 32977552
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lee, DH
   Jacobs, DR
   Gross, M
   Kiefe, CI
   Roseman, J
   Lewis, CE
   Steffes, M
AF Lee, DH
   Jacobs, DR
   Gross, M
   Kiefe, CI
   Roseman, J
   Lewis, CE
   Steffes, M
TI γ-glutamyltransferase is a predictor of incident diabetes and
   hypertension:: The coronary artery risk development in young adults
   (CARDIA) study
SO CLINICAL CHEMISTRY
LA English
DT Article
ID INSULIN-RESISTANCE SYNDROME; TRANSPEPTIDASE; ASSOCIATION; IRON;
   DETERMINANTS; EXPRESSION; POPULATION; ALCOHOL; CELLS;
   GLUTAMYLTRANSFERASE
AB Background: gamma-Glutamyltransferase (GGT), which maintains cellular concentrations of glutathione, may be a marker of oxidative stress, and GGT itself may produce oxidative stress. We performed a prospective study to examine whether serum GGT predicts diabetes and hypertension.
   Methods: Study participants were 4844 black and white men and women 18-30 years of age in 1985-1986; they were reexamined 2, 5, 7, 10, and 15 years later. Year 0 GGT cutpoints were 12, 17, 25, and 36 U/L (overall 25th, 50th, 75th, and 90th percentiles; the laboratory cutpoints for abnormal are 40 U/L in women and 50 U/L in men). We deleted 32 participants with prevalent diabetes and 140 participants with prevalent hypertension from the respective incidence analyses.
   Results: After adjustment for study center, race, sex, and age in proportional hazards regression, the hazard ratios across year 0 GGT categories were 1.0. 1.6, 1.7, 4.0 (95% confidence interval, 2.0-8.1), and 5.5 (2.7-11.1) for 15-year incident diabetes and 1.0, 1.2, 1.7 (1.2-2.2), 2.3 (1.7-3.2). and 2.3 (1.7-3.2) for hypertension. Additional adjustment for year 0 alcohol consumption, body mass index, cigarette smoking, and physical activity attenuated this relationship, but GGT remained a significant predictor.
   Conclusions: Serum GGT within a range regarded as physiologically normal is associated with incident diabetes and hypertension. Considering known functionality of GGT, these associations are consistent with a role for oxidative stress in risk for diabetes and hypertension. (C) 2003 American Association for Clinical Chemistry.
C1 Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN 55454 USA.
   Univ Minnesota, Sch Publ Hlth, Dept Lab Med & Pathol, Minneapolis, MN 55454 USA.
   Kosin Univ, Coll Med, Dept Prevent Med, Pusan 602202, South Korea.
   Univ Oslo, Inst Nutr Res, N-0316 Oslo, Norway.
   Univ Alabama, Div Prevent Med, Sch Med, Birmingham, AL 35205 USA.
   Univ Alabama, Dept Epidemiol, Sch Publ Hlth, Birmingham, AL 35205 USA.
   Vet Affairs Med Ctr, Birmingham, AL 35233 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities;
   University of Oslo; University of Alabama System; University of Alabama
   Birmingham; University of Alabama System; University of Alabama
   Birmingham; US Department of Veterans Affairs; Veterans Health
   Administration (VHA)
RP Jacobs, DR (corresponding author), Univ Minnesota, Sch Publ Hlth, Div Epidemiol, 1300 S 2nd St,Suite 300, Minneapolis, MN 55454 USA.
RI Jacobs, David/G-5405-2011
OI Jacobs, David/0000-0002-7232-0543
FU NHLBI NIH HHS [R01 HL053560, N01 HC 48050, R01 HL 53560, N01 HC 48049,
   N01 HC 48048, N01 HC 48047] Funding Source: Medline
CR Brenner H, 1997, PREV MED, V26, P305, DOI 10.1006/pmed.1997.0144
   Brown KE, 1998, FREE RADICAL BIO MED, V24, P545, DOI 10.1016/S0891-5849(97)00284-0
   Chitturi S, 2002, HEPATOLOGY, V35, P373, DOI 10.1053/jhep.2002.30692
   Cleland SJ, 2000, HYPERTENSION, V35, P507, DOI 10.1161/01.HYP.35.1.507
   Drozdz R, 1998, FREE RADICAL BIO MED, V25, P786, DOI 10.1016/S0891-5849(98)00127-0
   Duplain H, 2001, CIRCULATION, V104, P342, DOI 10.1161/01.CIR.104.3.342
   Fernández-Real JM, 2002, DIABETES, V51, P2348, DOI 10.2337/diabetes.51.8.2348
   FRIEDMAN GD, 1988, J CLIN EPIDEMIOL, V41, P1105, DOI 10.1016/0895-4356(88)90080-7
   Gillum RF, 2001, INT J OBESITY, V25, P639, DOI 10.1038/sj.ijo.0801561
   Haffner SM, 1997, J HYPERTENS, V15, pS25, DOI 10.1097/00004872-199715011-00003
   Jacobs David R Jr, 1989, J Cardiopulm Rehabil, V9, P448, DOI 10.1097/00008483-198911000-00003
   Jousilahti P, 2000, STROKE, V31, P1851, DOI 10.1161/01.STR.31.8.1851
   Karp DR, 2001, J BIOL CHEM, V276, P3798, DOI 10.1074/jbc.M008484200
   KUGELMAN A, 1994, AM J RESP CELL MOL, V11, P586, DOI 10.1165/ajrcmb.11.5.7946387
   LAKKA TA, 1994, AM J EPIDEMIOL, V140, P148, DOI 10.1093/oxfordjournals.aje.a117225
   Lee DH, 2003, DIABETOLOGIA, V46, P359, DOI 10.1007/s00125-003-1036-5
   Lee DH, 2002, ANN EPIDEMIOL, V12, P90, DOI 10.1016/S1047-2797(01)00252-6
   Marchesini G, 2001, DIABETES, V50, P1844, DOI 10.2337/diabetes.50.8.1844
   MIURA K, 1994, J HUM HYPERTENS, V8, P445
   Morrow JD, 1999, METHOD ENZYMOL, V300, P3
   NILSSEN O, 1990, AM J EPIDEMIOL, V132, P318, DOI 10.1093/oxfordjournals.aje.a115661
   NILSSEN O, 1994, AM J EPIDEMIOL, V139, P787, DOI 10.1093/oxfordjournals.aje.a117075
   NYSTROM E, 1988, ACTA MED SCAND, V224, P79
   Orie NN, 1999, AM J HYPERTENS, V12, P1169, DOI 10.1016/S0895-7061(99)00129-6
   Paolicchi A, 1997, FREE RADICAL BIO MED, V22, P853, DOI 10.1016/S0891-5849(96)00422-4
   Perry IJ, 1998, DIABETES CARE, V21, P732, DOI 10.2337/diacare.21.5.732
   STARK AA, 1994, CARCINOGENESIS, V15, P343, DOI 10.1093/carcin/15.2.343
   STARK AA, 1991, MUTAGENESIS, V6, P241, DOI 10.1093/mutage/6.4.241
   Takahashi Y, 1997, TOXICOL APPL PHARM, V143, P388, DOI 10.1006/taap.1996.8087
   TESCHKE R, 1977, BIOCHEM BIOPH RES CO, V75, P718, DOI 10.1016/0006-291X(77)91531-5
   WANNAMETHEE G, 1995, AM J EPIDEMIOL, V142, P699, DOI 10.1093/oxfordjournals.aje.a117699
   Zacharski LR, 2000, AM HEART J, V140, P98, DOI 10.1067/mhj.2000.106646
NR 32
TC 399
Z9 423
U1 0
U2 12
PU AMER ASSOC CLINICAL CHEMISTRY
PI WASHINGTON
PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA
SN 0009-9147
J9 CLIN CHEM
JI Clin. Chem.
PD AUG
PY 2003
VL 49
IS 8
BP 1358
EP 1366
DI 10.1373/49.8.1358
PG 9
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 705CR
UT WOS:000184378900018
PM 12881453
OA Bronze
DA 2025-06-11
ER

PT J
AU He, QQ
   Tang, YG
   Li, YZ
   Wang, F
   Bao, JS
   Gupta, S
AF He, Qiqi
   Tang, Yangguo
   Li, Yuzhuo
   Wang, Fei
   Bao, Junsheng
   Gupta, Sanjay
TI A pilot dynamic analysis of formative factors of nephrolithiasis related
   to metabolic syndrome: evidence in a rat model
SO RENAL FAILURE
LA English
DT Article
DE Nephrolithiasis; metabolic syndrome; high oxalate urine; animal model
ID KIDNEY-STONE; OBESITY; RISK; MANIFESTATION; ASSOCIATION; COMPONENTS
AB Introduction and objective To examine the dynamic changes in the formative factors of nephrolithiasis and the final micromorphological changes in an obesity-initiated metabolic syndrome (MS) rat model. Methods Forty five-week-old male Sprague-Dawley (SD) rats were randomly divided into four groups: the regular diet group (RD), high-fat diet group (HFD), regular diet with drug (ethylene glycol and ammonium chloride) group (RDD), and high-fat diet with drug group (HFDD). A dynamic assessment of MS components (body weight (BW), body length (BL), Lee's index (LI), blood glucose (BG), total cholesterol (TC), and triglycerides (TGs)) and stone-forming factors (urinary pH, urinary calcium, and urinary oxalate acid) was carried out. In addition, the levels of oxidative stress (OS) markers (CAT, SOD, TAC, GSH-PX, and MDA) were measured, and histological analysis was carried out at the end of 16 weeks. Results MS-related parameters, such as BW, LI, BG, TC, and TG, were significantly higher in HFD-fed rats than in RD-fed rats (p < 0.001). In the HFDD group, significantly lower urinary pH, hyperoxaluria, and hypocalciuria were noted in the dynamic assessment of stone-forming factors (p < 0.001). CAT, TAC, and MDA were notably changed in the HFD-fed groups, particularly the HFDD rats. Histological analysis showed that the renal tubules of HFDD rats had the highest scores for both inflammation and renal crystallization deposition (p < 0.05). Conclusions Our results suggest that male SD rats with MS are prone to developing nephrolithiasis. Validation in an in vivo model may lead to an understanding of the underlying pathophysiological mechanisms of action of MS-related nephrolithiasis in humans. Key messages Male SD rats with metabolic syndrome are more prone to developing calcium oxalate nephrolithiasis after treatment with ethylene glycol and ammonium chloride compared to control lean rats. MS-related nephrolithiasis in rats induced by ethylene glycol and ammonium chloride is mainly related to increased hyperoxaluria and inflammation and decreased antioxidant levels. High-fat diet-fed SD rats treated with ethylene glycol and ammonium chloride are a stable and valid in vivo model for understanding the potential mechanism of action of MS-related nephrolithiasis.
C1 [He, Qiqi; Tang, Yangguo; Li, Yuzhuo; Bao, Junsheng] Lanzhou Univ, Hosp 2, Gansu Nephro Urol Clin Ctr, Dept Urol,Key Lab Dis Urol Syst, 80 Cui YinMen St, Lanzhou 730030, Gansu, Peoples R China.
   [Tang, Yangguo] Guangxi Univ, Coll Anim Sci & Technol, Nanning, Peoples R China.
   [Wang, Fei] Lanzhou Univ, Hosp 2, Dept Paediat, Lanzhou, Peoples R China.
   [Gupta, Sanjay] Case Western Reserve Univ, Case Med Ctr, Univ Hosp, Dept Urol, Cleveland, OH 44106 USA.
C3 Lanzhou University; Guangxi University; Lanzhou University; University
   System of Ohio; Case Western Reserve University; University Hospitals of
   Cleveland
RP He, QQ (corresponding author), Lanzhou Univ, Hosp 2, Gansu Nephro Urol Clin Ctr, Dept Urol,Key Lab Dis Urol Syst, 80 Cui YinMen St, Lanzhou 730030, Gansu, Peoples R China.
EM ery_heqq@lzu.edu.cn
FU National Natural Science Foundation of China [81800671]; Cuiyin Talent
   Program [CY2021-MS-A02]; Gansu Health industry Scientific Research
   Program [GSWSKY2021-070]; Lanzhou Science & Technology Project
   [2022-ZD-105]
FX This work was supported by the National Natural Science Foundation of
   China [81800671], Cuiyin Talent Program [CY2021-MS-A02], Gansu Health
   industry Scientific Research Program [GSWSKY2021-070] and Lanzhou
   Science & Technology Project [2022-ZD-105].
CR Abate N, 2004, KIDNEY INT, V65, P386, DOI 10.1111/j.1523-1755.2004.00386.x
   Ahmed OM, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10091317
   Bihl G, 2001, LANCET, V358, P651, DOI 10.1016/S0140-6736(01)05782-8
   Chaiyarit S, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.566506
   [陈晓琴 CHEN Xiaoqin], 2009, [天津医药, Tianjin Medical Journal], V37, P923
   Cupisti A, 2014, J NEPHROL, V27, P477, DOI 10.1007/s40620-014-0068-x
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Domingos F, 2014, SCAND J UROL, V48, P414, DOI 10.3109/21681805.2014.903513
   Eckel RH, 2010, LANCET, V375, P181, DOI 10.1016/S0140-6736(09)61794-3
   Grundy SM, 2004, J CLIN ENDOCR METAB, V89, P2595, DOI 10.1210/jc.2004-0372
   Haymann JP, 2015, WORLD J UROL, V33, P187, DOI 10.1007/s00345-014-1391-5
   He QQ, 2016, PROSTATE, V76, P964, DOI 10.1002/pros.23185
   He QQ, 2014, AGING MALE, V17, P223, DOI 10.3109/13685538.2014.967671
   Kim YJ, 2013, METABOLISM, V62, P808, DOI 10.1016/j.metabol.2012.12.010
   Kohjimoto Y, 2013, AM J KIDNEY DIS, V61, P923, DOI 10.1053/j.ajkd.2012.12.028
   Lee YC, 2016, AGING MALE, V19, P197, DOI 10.1080/13685538.2016.1174987
   Li XR, 2015, MOL CELL BIOCHEM, V399, P167, DOI 10.1007/s11010-014-2243-8
   Liu YD, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/4826525
   Liu YT, 2017, THER CLIN RISK MANAG, V13, P41, DOI 10.2147/TCRM.S125480
   Rahman Ilham Akbar, 2021, F1000Res, V10, P104, DOI 10.12688/f1000research.28346.1
   Sáenz-Medina J, 2018, UROLITHIASIS, V46, P179, DOI 10.1007/s00240-017-0979-9
   Taguchi K, 2020, KIDNEY INT, V97, P1042, DOI 10.1016/j.kint.2020.01.042
   Taguchi K, 2015, J UROLOGY, V194, P1787, DOI 10.1016/j.juro.2015.07.083
   Taylor EN, 2005, JAMA-J AM MED ASSOC, V293, P455, DOI 10.1001/jama.293.4.455
   Wong SK, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0123-9
NR 25
TC 2
Z9 2
U1 1
U2 14
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0886-022X
EI 1525-6049
J9 RENAL FAILURE
JI Ren. Fail.
PD DEC 31
PY 2022
VL 44
IS 1
BP 1134
EP 1143
DI 10.1080/0886022X.2022.2097922
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 2Y5RA
UT WOS:000825952800001
PM 35837686
OA Green Published
DA 2025-06-11
ER

PT J
AU Krishnaveni, GV
   Veena, SR
   Johnson, M
   Kumaran, K
   Jones, A
   Bhat, DS
   Yajnik, CS
   Fall, CHD
AF Krishnaveni, Ghattu, V
   Veena, Sargoor R.
   Johnson, Matt
   Kumaran, Kalyanaraman
   Jones, Alexander
   Bhat, Dattatray S.
   Yajnik, Chittaranjan S.
   Fall, Caroline H. D.
TI Maternal B12, Folate and Homocysteine Concentrations and Offspring
   Cortisol and Cardiovascular Responses to Stress
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE B12 deficiency; folate; homocysteine; stress response; cortisol;
   adolescent
ID FOLIC-ACID; BIRTH-WEIGHT; MICROBIOLOGICAL ASSAY; VITAMIN-B-12 STATUS;
   INSULIN-RESISTANCE; COGNITIVE FUNCTION; MENTAL STRESS; PREGNANCY; RISK;
   NUTRITION
AB Context: Imbalances in maternal 1-carbon nutrients (vitamin B12, folate) have been shown to be associated with higher offspring cardiometabolic risk markers in India.
   Objective: We examined the hypothesis that low plasma vitamin B12 (B12) and high folate and homocysteine concentrations in the mother are associated with higher hypothalamic-pituitary-adrenal axis (cortisol) and cardiovascular responses during the Trier Social Stress Test for Children (TSST-C) in an Indian birth cohort.
   Methods: Adolescents (n = 264; mean age: 13.6 years), whose mothers' plasma B12, folate and total homocysteine concentrations had been measured during pregnancy, completed 5-minutes each of public speaking and mental arithmetic tasks in front of 2 unfamiliar "judges" (TSST-C). Baseline and poststress salivary cortisol concentrations were measured. Heart rate, blood pressure, stroke volume, cardiac output, and total peripheral resistance were measured continuously at baseline, during the TSST-C, and for 10 minutes after the TSST-C using a finger cuff; beat-to-beat values were averaged for these periods, respectively.
   Results: Maternal low B12 status (plasma B12 < 150 pmol/L) was associated with greater cortisol responses to stress in the offspring (P < .001). Higher homocysteine concentrations were associated with greater offspring heart rate response (P < .001). After adjustment for multiple comparisons, there were nonsignificant associations between higher maternal folate concentrations and offspring total peripheral resistance response (P = .01).
   Conclusion: Our findings suggest that maternal 1-carbon nutritional status may have long-term programming implications for offspring neuroendocrine stress responses.
C1 [Krishnaveni, Ghattu, V; Veena, Sargoor R.; Kumaran, Kalyanaraman] CSI Holdsworth Mem Hosp, Epidemiol Res Unit, Mysore, Karnataka, India.
   [Johnson, Matt; Kumaran, Kalyanaraman; Fall, Caroline H. D.] Southampton Gen Hosp, MRC, Lifecourse Epidemiol Unit, Southampton, Hants, England.
   [Jones, Alexander] Univ Oxford, Dept Paediat, Oxford, England.
   [Bhat, Dattatray S.; Yajnik, Chittaranjan S.] King Edward Mem Hosp & Res Ctr, Diabet Unit, Pune, Maharashtra, India.
C3 University of Southampton; University of Oxford
RP Krishnaveni, GV (corresponding author), CSI Holdsworth Mem Hosp, Post Box 38, Mysore 570001, Karnataka, India.
EM gv.krishnaveni@gmail.com
RI Kumaran, Kalyanaraman/KCK-5741-2024
OI Krishnaveni, Ghattu V/0000-0002-6532-8272
FU Wellcome Trust UK [095147/Z/1O/Z]; Parthenon Trust; Wellcome Trust;
   Medical Research Council (UK); Department for International Development
   (UK); Wellcome Trust-DBT India Alliance Senior Fellowship; MRC
   [G0400519, MC_UU_12011/3, MC_PC_MR/R018545/1, MC_UP_A620_1016,
   MC_U147585821] Funding Source: UKRI
FX The study was supported by the Wellcome Trust UK as part of a personal
   fellowship to GVK (095147/Z/1O/Z). The Parthenon Cohort was funded by
   the Parthenon Trust, the Wellcome Trust, the Medical Research Council
   (UK) and the Department for International Development (UK). GVK is
   currently supported by a Wellcome Trust-DBT India Alliance Senior
   Fellowship.
CR [Anonymous], 2001, National Family Health Survey (NFHS-2), 1998-99
   BARKER DJP, 1993, LANCET, V341, P938, DOI 10.1016/0140-6736(93)91224-A
   Bhate V, 2008, FOOD NUTR BULL, V29, P249, DOI 10.1177/156482650802900401
   Brotman LM, 2007, ARCH GEN PSYCHIAT, V64, P1172, DOI 10.1001/archpsyc.64.10.1172
   Chida Y, 2010, HYPERTENSION, V55, P1026, DOI 10.1161/HYPERTENSIONAHA.109.146621
   Feldt K, 2011, J HUM HYPERTENS, V25, P231, DOI 10.1038/jhh.2010.55
   Godbole K, 2011, BIRTH DEFECTS RES A, V91, P848, DOI 10.1002/bdra.20841
   HORNE DW, 1988, CLIN CHEM, V34, P2357
   Jones A, 2006, J CLIN ENDOCR METAB, V91, P1868, DOI 10.1210/jc.2005-2077
   Jones A, 2008, EUR HEART J, V29, P2164, DOI 10.1093/eurheartj/ehn292
   KELLEHER BP, 1987, CLIN CHEM, V33, P52
   Krishnaveni G V, 2018, Wellcome Open Res, V3, P56, DOI 10.12688/wellcomeopenres.14583.1
   Krishnaveni GV, 2014, INDIAN PEDIATR, V51, P463, DOI 10.1007/s13312-014-0437-5
   Krishnaveni GV, 2009, DIABETOLOGIA, V52, P2350, DOI 10.1007/s00125-009-1499-0
   Krishnaveni GV, 2015, INT J EPIDEMIOL, V44, P28, DOI 10.1093/ije/dyu050
   Krishnaveni GV, 2014, DIABETOLOGIA, V57, P110, DOI 10.1007/s00125-013-3086-7
   LangleyEvans SC, 1996, J NUTR, V126, P1578, DOI 10.1093/jn/126.6.1578
   McEwen BS, 2008, EUR J PHARMACOL, V583, P174, DOI 10.1016/j.ejphar.2007.11.071
   McGarel C, 2015, P NUTR SOC, V74, P46, DOI 10.1017/S0029665114001554
   Phillips DIW, 2006, ANN NY ACAD SCI, V1083, P28, DOI 10.1196/annals.1367.027
   Poore KR, 2010, J PHYSIOL-LONDON, V588, P2219, DOI 10.1113/jphysiol.2010.187682
   Roy S, 2014, BRAIN DEV-JPN, V36, P219, DOI 10.1016/j.braindev.2013.03.004
   Sauer J, 2009, CURR OPIN CLIN NUTR, V12, P30, DOI 10.1097/MCO.0b013e32831cec62
   Morris MS, 2007, AM J CLIN NUTR, V85, P193, DOI 10.1093/ajcn/85.1.193
   SHIPCHANDLER MT, 1995, CLIN CHEM, V41, P991
   Smith AD, 2008, AM J CLIN NUTR, V87, P517
   Sucharita S, 2014, MATERN CHILD NUTR, V10, P226, DOI 10.1111/j.1740-8709.2012.00418.x
   Tanner J.M., 1962, Growth at Adolescence, V2nd ed.
   Veena SR, 2010, J NUTR, V140, P1014, DOI 10.3945/jn.109.118075
   Wüst S, 2005, PSYCHONEUROENDOCRINO, V30, P591, DOI 10.1016/j.psyneuen.2005.01.008
   Yajnik CS, 2008, DIABETOLOGIA, V51, P29, DOI 10.1007/s00125-007-0793-y
   Yajnik CS, 2014, INT J EPIDEMIOL, V43, P1487, DOI 10.1093/ije/dyu132
   Yajnik CS, 2009, INT J GYNECOL OBSTET, V104, pS27, DOI 10.1016/j.ijgo.2008.11.034
NR 33
TC 6
Z9 6
U1 1
U2 5
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JUL
PY 2020
VL 105
IS 7
BP E2591
EP E2599
DI 10.1210/clinem/dgz114
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA NJ3BF
UT WOS:000565922200029
PM 32206806
OA Green Published, Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Weigensberg, MJ
   Wen, CKF
   Sanogo, F
   Toledo-Corral, C
   Ding, L
AF Weigensberg, Marc J.
   Wen, Cheng K. F.
   Sanogo, Fatimata
   Toledo-Corral, Claudia
   Ding, Li
TI Imagine HEALTH: Changes in diurnal salivary cortisol patterns following
   a 12-week guided imagery RCT lifestyle intervention in predominantly
   Latino adolescents
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Guided imagery; Adolescents; Latino; Obesity; Stress reduction; Cortisol
ID PITUITARY-ADRENAL AXIS; METABOLIC SYNDROME; AWAKENING RESPONSE;
   STRESS-REDUCTION; HIGH-SCHOOL; OVERWEIGHT; CHILDREN; NEUROENDOCRINE;
   ASSOCIATION; DEPRESSION
AB Objective: Alterations in diurnal salivary cortisol patterns have been linked to adverse metabolic health outcomes. We have previously shown that stress-reduction guided imagery (GI) can reduce salivary cortisol levels acutely. We now ask whether addition of GI into a 12-week lifestyle intervention designed to improve eating and physical activity behaviors can alter diurnal salivary cortisol patterns and perceived stress.Methods: 232 adolescent participants (ages 14-17 years) were cluster randomized by school into one of four intervention arms: non-intervention Control (C; n = 51), Lifestyle (LS; n=61), Stress-Reduction GI (SRGI; n = 55), and Lifestyle Behavior GI (LBGI; n = 65). LS group received one nutrition and one physical activity class per week after-school for 12 weeks. SRGI and LBGI groups received same LS classes plus an additional weekly GI session. Salivary cortisol was assessed pre-and post-intervention on 3 days, 3 times daily, at awakening, 30 -mi-nutes post-awakening, and in the evening to determine Cortisol Awakening Response (CAR) and Diurnal Cortisol Slope (DCS). Perceived Stress Scale (PSS) was administered pre-and post-intervention. Mixed effects modeling was used for intent-to-treat analysis and sensitivity analysis was used for those participants adherent to inter-vention protocol. Results: Analysis of 208 subjects with complete data showed a small between-group increase in CAR in LBGI vs C (p = 0.045, d=0.24), with no significant group differences among other intervention arms. There were no be-tween group differences in change in DCS or change in PSS after 12-weeks. Amongst adherent participants, LBGI showed a small-moderate increase in CAR (p = 0.03, d=0.37), and moderate-large reduction in PSS (p = 0.02, d=-0.66) compared to C. There were no other between group differences in CAR, DCS, or PSS.Conclusion: LBGI led to an increase in CAR, and in adherent subjects, a decrease in PSS, suggesting GI may be a mind-body intervention that can affect both objective and subjective measures of the stress response. Whether changes in cortisol patterns in this population affect measures of mental or physical health remains to be determined.
C1 [Weigensberg, Marc J.] USC Keck Sch Med, Dept Pediat, Los Angeles, CA 90033 USA.
   [Wen, Cheng K. F.] USC Ctr Self Report Sci, Los Angeles, CA USA.
   [Sanogo, Fatimata] USC Keck Sch Med, Dept Populat & Publ Hlth Sci, Los Angeles, CA USA.
   [Toledo-Corral, Claudia] Calif State Univ Northridge, Dept Hlth Sci, Northridge, CA USA.
   [Ding, Li] USC Keck Sch Med, Dept Populat & Publ Hlth Sci, Div Biostat, Los Angeles, CA USA.
C3 University of Southern California; University of Southern California;
   California State University System; California State University
   Northridge; University of Southern California
RP Weigensberg, MJ (corresponding author), USC Keck Sch Med, Dept Pediat, Los Angeles, CA 90033 USA.
EM weigensb@usc.edu
RI Toledo-Corral, Claudia/J-5299-2019; Ding, Li/G-4031-2019; Wen,
   Cheng/J-6672-2019
OI Wen, Cheng K. Fred/0000-0002-2538-0439
FU NIH National Center for Complementary and Integrative Health
   [R01AT008330, UL1TR001855, UL1TR000130]
FX Funding: This work was sponsored by NIH National Center for
   Complementary and Integrative Health, R01AT008330. This work was
   supported by grants UL1TR001855 and UL1TR000130 from the
CR Adam EK, 2017, PSYCHONEUROENDOCRINO, V83, P25, DOI 10.1016/j.psyneuen.2017.05.018
   Adam TC, 2010, J CLIN ENDOCR METAB, V95, P4729, DOI 10.1210/jc.2010-0322
   Agorastos A, 2022, MOL PSYCHIATR, V27, P502, DOI 10.1038/s41380-021-01224-9
   Association American Psychological, 2014, STRESS AM AR TEENS A
   Association American Psychological, 2018, STRESS AM GEN Z
   Barlow SE, 2007, PEDIATRICS, V120, pS164, DOI 10.1542/peds.2007-2329C
   Björntorp P, 2000, INT J OBESITY, V24, pS80, DOI 10.1038/sj.ijo.0801285
   Booth RW, 2016, SOC PSYCH PSYCH EPID, V51, P193, DOI 10.1007/s00127-015-1096-0
   Bruehl H, 2009, PSYCHONEUROENDOCRINO, V34, P815, DOI 10.1016/j.psyneuen.2008.12.010
   Carlson LE, 2004, PSYCHONEUROENDOCRINO, V29, P448, DOI 10.1016/S0306-4530(03)00054-4
   Champaneri S, 2012, METABOLISM, V61, P986, DOI 10.1016/j.metabol.2011.11.006
   Chida Y, 2009, BIOL PSYCHOL, V80, P265, DOI 10.1016/j.biopsycho.2008.10.004
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Cruz ML, 2004, J CLIN ENDOCR METAB, V89, P108, DOI 10.1210/jc.2003-031188
   Dabelea D, 2007, JAMA-J AM MED ASSOC, V297, P2716, DOI 10.1001/jama.297.24.2716
   Davis J.N., 2007, AM J CLIN NUTR
   Davis JN, 2010, INT J PEDIATR OBES, V5, P451, DOI 10.3109/17477161003770123
   de Anda D, 2000, CHILD YOUTH SERV REV, V22, P441
   Dedovic K, 2015, NEUROPSYCH DIS TREAT, V11, P1181, DOI 10.2147/NDT.S62289
   DeSantis AS, 2010, INT J BEHAV MED, V17, P74, DOI 10.1007/s12529-009-9053-5
   Emmanouil CC, 2018, HORM-INT J ENDOCRINO, V17, P405, DOI 10.1007/s42000-018-0052-2
   Farley Tillman, 2005, J Immigr Health, V7, P213, DOI 10.1007/s10903-005-3678-5
   Goran MI, 2004, J CLIN ENDOCR METAB, V89, P207, DOI 10.1210/jc.2003-031402
   Hackett RA, 2016, J CLIN ENDOCR METAB, V101, P619, DOI 10.1210/jc.2015-2853
   Hackett RA, 2014, J CLIN ENDOCR METAB, V99, P4625, DOI 10.1210/jc.2014-2459
   Hammerfald K, 2006, PSYCHONEUROENDOCRINO, V31, P333, DOI 10.1016/j.psyneuen.2005.08.007
   Holland JM, 2011, STRESS HEALTH, V27, P334, DOI 10.1002/smi.1375
   Joseph JJ, 2017, ANN NY ACAD SCI, V1391, P20, DOI 10.1111/nyas.13217
   Joseph JJ, 2015, PSYCHONEUROENDOCRINO, V62, P327, DOI 10.1016/j.psyneuen.2015.08.021
   Kumari M, 2011, J CLIN ENDOCR METAB, V96, P1478, DOI 10.1210/jc.2010-2137
   Lederbogen F, 2011, EXP CLIN ENDOCR DIAB, V119, P573, DOI 10.1055/s-0031-1275288
   Lopez-Duran NL, 2009, PSYCHONEUROENDOCRINO, V34, P1272, DOI 10.1016/j.psyneuen.2009.03.016
   Miller R, 2016, PSYCHONEUROENDOCRINO, V73, P16, DOI 10.1016/j.psyneuen.2016.07.201
   MORRIS NM, 1980, J YOUTH ADOLESCENCE, V9, P271, DOI 10.1007/BF02088471
   Nguyen-Rodriguez Selena T, 2008, Eat Behav, V9, P238, DOI 10.1016/j.eatbeh.2007.09.001
   Ogden CL, 2016, JAMA-J AM MED ASSOC, V315, P2292, DOI 10.1001/jama.2016.6361
   Ortiz R, 2022, TRENDS ENDOCRIN MET, V33, P786, DOI 10.1016/j.tem.2022.08.002
   Pawlow LA, 2002, BIOL PSYCHOL, V60, P1, DOI 10.1016/S0301-0511(02)00010-8
   Powell DJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0052067
   Reyes O, 2000, AM J COMMUN PSYCHOL, V28, P519, DOI 10.1023/A:1005140631988
   Rosmond R, 2000, J INTERN MED, V247, P188, DOI 10.1046/j.1365-2796.2000.00603.x
   Rotenberg S, 2012, PSYCHONEUROENDOCRINO, V37, P1981, DOI 10.1016/j.psyneuen.2012.04.014
   Sanogo F, 2022, BMJ-BRIT MED J, V00, P1
   Simons SSH, 2015, PSYCHONEUROENDOCRINO, V62, P292, DOI 10.1016/j.psyneuen.2015.08.024
   Sisk LM, 2022, CURR OPIN PSYCHOL, V44, P286, DOI 10.1016/j.copsyc.2021.10.005
   Stalder T, 2016, PSYCHONEUROENDOCRINO, V63, P414, DOI 10.1016/j.psyneuen.2015.10.010
   Stavrou Stavroula, 2016, J Mol Biochem, V5, P63
   Stone AA, 2003, CONTROL CLIN TRIALS, V24, P182, DOI 10.1016/S0197-2456(02)00320-3
   Strait Robert B, 2018, J Child Obes, V3, DOI 10.21767/2572-5394.100048
   Toledo-Corral CM, 2013, PSYCHONEUROENDOCRINO, V38, P1658, DOI 10.1016/j.psyneuen.2013.01.011
   Tribole E., 1995, INTUITIVE EATING
   Twenge JM, 2000, J PERS SOC PSYCHOL, V79, P1007, DOI 10.1037//0022-3514.79.6.1007
   Urizar GG, 2021, INT J BEHAV MED, V28, P627, DOI 10.1007/s12529-021-09957-1
   Urizar GG, 2019, PSYCHONEUROENDOCRINO, V104, P174, DOI 10.1016/j.psyneuen.2019.02.022
   Weigensberg M.J., 2022, J ALTERN COMPLEM MED, V11
   Weigensberg MJ, 2008, J CLIN ENDOCR METAB, V93, P1372, DOI 10.1210/jc.2007-2309
   Weigensberg MJ, 2021, J ALTERN COMPLEM MED, V27, P738, DOI 10.1089/acm.2020.0515
   Weigensberg MJ, 2018, CONTEMP CLIN TRIALS, V72, P103, DOI 10.1016/j.cct.2018.07.009
   Weigensberg MJ, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-28
   Weigensberg MJ, 2009, J ALTERN COMPLEM MED, V15, P297, DOI 10.1089/acm.2008.0156
   Weigensberg MJ, 2019, GLOB ADV HLTH MED, V8, P1
   Wen C.K.F., 2022, PEDIATR OBES
   Williams D.R., 2000, RACE STRESS MENT HLT, P209
   Wüst S, 2000, PSYCHONEUROENDOCRINO, V25, P707, DOI 10.1016/S0306-4530(00)00021-4
NR 65
TC 1
Z9 1
U1 2
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAY
PY 2023
VL 151
AR 106053
DI 10.1016/j.psyneuen.2023.106053
EA FEB 2023
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 9W4CJ
UT WOS:000949025800001
PM 36842257
OA Bronze
DA 2025-06-11
ER

PT J
AU Lee, DH
   Ha, MH
   Kim, JH
   Christiani, DC
   Gross, MD
   Steffes, M
   Blomhoff, R
   Jacobs, DR
AF Lee, DH
   Ha, MH
   Kim, JH
   Christiani, DC
   Gross, MD
   Steffes, M
   Blomhoff, R
   Jacobs, DR
TI Gamma-glutamyltransferase and diabetes - a 4 year follow-up study
SO DIABETOLOGIA
LA English
DT Article
DE gamma glutamyltransferase; obesity; age; diabetes
ID OXIDATIVE STRESS; TRANSPEPTIDASE; DETERMINANTS; ASSOCIATION; POPULATION;
   EXPRESSION; ALCOHOL; MORTALITY; RADICALS; DISEASE
AB Aims/Hypothesis. Gamma-glutamyltransferase (GGT) is located on the external surface of most cells and mediates the uptake of gluthathione, an important component of intracellular antioxidant defenses. An increase in GGT concentration has been regarded as a marker of alcohol consumption or liver disease. However, more subtle gradations in GGT could be informative because its expression is enhanced by oxidative stress and it could be released by several conditions inducing cellular stress. Recently, serum GGT concentrations have been associated with many cardiovascular disease risk factors or components of the insulin resistance syndrome. We did a prospective study with the hypothesis that serum GGT is a predictor of incident diabetes.
   Methods. A total of 4,088 healthy men working in a steel manufacturing company were examined in 1994 and 1998. Diabetes was defined as a serum fasting glucose concentration of more than 126 mg/dl or the use of diabetes medication.
   Results. There was a strong dose-response relation between serum GGT concentrations at baseline and the incidence of diabetes. In contrast to the 31% of men with GGT concentrations under 9 U/l, adjusted relative risks for incidence of diabetes for GGT concentrations 10-19, 20-29, 30-39, 40-49, and over 50 U/l were 8.0, 13.3, 12.6, 19.6 and 25.8, respectively. The associations of age and BMI with incident diabetes became stronger the higher the value of baseline serum GGT concentration.
   Conclusion/interpretation. This study suggests that an increase in GGT concentration within its physiological range is a sensitive and early biomarker for the development of diabetes.
C1 Kosin Univ, Dept Prevent Med, Suh Gu, Pusan 602702, South Korea.
   Pohang Steel Co, Hlth Care Ctr, Pohang, South Korea.
   Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.
   Univ Minnesota, Sch Publ Hlth, Dept Lab Med, Minneapolis, MN 55455 USA.
   Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN 55455 USA.
   Univ Oslo, Inst Nutr Res, Oslo, Norway.
   Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN 55455 USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health;
   University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities;
   University of Oslo; University of Minnesota System; University of
   Minnesota Twin Cities
RP Kosin Univ, Dept Prevent Med, Suh Gu, 34 Amnan Dong, Pusan 602702, South Korea.
EM ducky@ns.kosinmed.or.kr
RI Jacobs, David/G-5405-2011
OI Jacobs, David/0000-0002-7232-0543
CR Bakker SJL, 2000, ATHEROSCLEROSIS, V148, P17, DOI 10.1016/S0021-9150(99)00329-9
   Brenner H, 1997, PREV MED, V26, P305, DOI 10.1006/pmed.1997.0144
   Chitturi S, 2002, HEPATOLOGY, V35, P373, DOI 10.1053/jhep.2002.30692
   Custro N, 2001, DIABETES METAB, V27, P476
   Dröge W, 2002, PHYSIOL REV, V82, P47, DOI 10.1152/physrev.00018.2001
   Drozdz R, 1998, FREE RADICAL BIO MED, V25, P786, DOI 10.1016/S0891-5849(98)00127-0
   Haluzík M, 2000, PHYSIOL RES, V49, pS37
   Hanigan MH, 1996, J HISTOCHEM CYTOCHEM, V44, P1101, DOI 10.1177/44.10.8813074
   Hensley K, 2002, ARCH BIOCHEM BIOPHYS, V397, P377, DOI 10.1006/abbi.2001.2630
   IKEDA Y, 1995, P NATL ACAD SCI USA, V92, P126, DOI 10.1073/pnas.92.1.126
   Jousilahti P, 2000, STROKE, V31, P1851, DOI 10.1161/01.STR.31.8.1851
   Joyce-Brady M, 2001, J BIOL CHEM, V276, P9468, DOI 10.1074/jbc.M004352200
   Karp DR, 2001, J BIOL CHEM, V276, P3798, DOI 10.1074/jbc.M008484200
   KUGELMAN A, 1994, AM J RESP CELL MOL, V11, P586, DOI 10.1165/ajrcmb.11.5.7946387
   Lee DH, 2002, ANN EPIDEMIOL, V12, P90, DOI 10.1016/S1047-2797(01)00252-6
   Marchesini G, 2001, DIABETES, V50, P1844, DOI 10.2337/diabetes.50.8.1844
   Mehta SH, 2000, ANN INTERN MED, V133, P592, DOI 10.7326/0003-4819-133-8-200010170-00009
   MIURA K, 1994, J HUM HYPERTENS, V8, P445
   NILSSEN O, 1990, AM J EPIDEMIOL, V132, P318, DOI 10.1093/oxfordjournals.aje.a115661
   NILSSEN O, 1994, AM J EPIDEMIOL, V139, P787, DOI 10.1093/oxfordjournals.aje.a117075
   NYSTROM E, 1988, ACTA MED SCAND, V224, P79
   Perry IJ, 1998, DIABETES CARE, V21, P732, DOI 10.2337/diacare.21.5.732
   Rösen P, 2001, DIABETES-METAB RES, V17, P189, DOI 10.1002/dmrr.196
   STARK AA, 1994, CARCINOGENESIS, V15, P343, DOI 10.1093/carcin/15.2.343
   Takahashi Y, 1997, TOXICOL APPL PHARM, V143, P388, DOI 10.1006/taap.1996.8087
   TESCHKE R, 1977, BIOCHEM BIOPH RES CO, V75, P718, DOI 10.1016/0006-291X(77)91531-5
   Vlassara H, 2002, J INTERN MED, V251, P87, DOI 10.1046/j.1365-2796.2002.00932.x
   WANNAMETHEE G, 1995, AM J EPIDEMIOL, V142, P699, DOI 10.1093/oxfordjournals.aje.a117699
   West IC, 2000, DIABETIC MED, V17, P171, DOI 10.1046/j.1464-5491.2000.00259.x
NR 29
TC 274
Z9 295
U1 0
U2 11
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD MAR
PY 2003
VL 46
IS 3
BP 359
EP 364
DI 10.1007/s00125-003-1036-5
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 674CV
UT WOS:000182620000007
PM 12687334
OA Bronze
DA 2025-06-11
ER

PT J
AU Panazzolo, DG
   Sicuro, FL
   Clapauch, R
   Maranhao, PA
   Bouskela, E
   Kraemer-Aguiar, LG
AF Panazzolo, Diogo G.
   Sicuro, Fernando L.
   Clapauch, Ruth
   Maranhao, Priscila A.
   Bouskela, Eliete
   Kraemer-Aguiar, Luiz G.
TI Obesity, metabolic syndrome, impaired fasting glucose, and microvascular
   dysfunction: a principal component analysis approach
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Article
DE Microcirculation; Capillaries; Obesity; Metabolic syndrome; Impaired
   fasting glucose; Principal component analysis
ID ACUTE CORONARY SYNDROMES; ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE;
   NORMOGLYCEMIC SUBJECTS; WAIST CIRCUMFERENCE; ASSOCIATION; ADOLESCENTS;
   GLYCOCALYX; HORMONE; STRESS
AB Background: We aimed to evaluate the multivariate association between functional microvascular variables and clinical-laboratorial-anthropometrical measurements.
   Methods: Data from 189 female subjects (34.0 +/- 15.5 years, 30.5 +/- 7.1 kg/m(2)), who were non-smokers, non-regular drug users, without a history of diabetes and/or hypertension, were analyzed by principal component analysis (PCA). PCA is a classical multivariate exploratory tool because it highlights common variation between variables allowing inferences about possible biological meaning of associations between them, without pre-establishing cause-effect relationships. In total, 15 variables were used for PCA: body mass index (BMI), waist circumference, systolic and diastolic blood pressure (BP), fasting plasma glucose, levels of total cholesterol, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides (TG), insulin, C-reactive protein (CRP), and functional microvascular variables measured by nailfold videocapillaroscopy. Nailfold videocapillaroscopy was used for direct visualization of nutritive capillaries, assessing functional capillary density, red blood cell velocity (RBCV) at rest and peak after 1 min of arterial occlusion (RBCVmax), and the time taken to reach RBCVmax (TRBCVmax).
   Results: A total of 35% of subjects had metabolic syndrome, 77% were overweight/obese, and 9.5% had impaired fasting glucose. PCA was able to recognize that functional microvascular variables and clinical-laboratorial-anthropometrical measurements had a similar variation. The first five principal components explained most of the intrinsic variation of the data. For example, principal component 1 was associated with BMI, waist circumference, systolic BP, diastolic BP, insulin, TG, CRP, and TRBCVmax varying in the same way. Principal component 1 also showed a strong association among HDL-c, RBCV, and RBCVmax, but in the opposite way. Principal component 3 was associated only with microvascular variables in the same way (functional capillary density, RBCV and RBCVmax). Fasting plasma glucose appeared to be related to principal component 4 and did not show any association with microvascular reactivity.
   Conclusions: In non-diabetic female subjects, a multivariate scenario of associations between classic clinical variables strictly related to obesity and metabolic syndrome suggests a significant relationship between these diseases and microvascular reactivity.
C1 [Panazzolo, Diogo G.; Sicuro, Fernando L.; Clapauch, Ruth; Maranhao, Priscila A.; Bouskela, Eliete; Kraemer-Aguiar, Luiz G.] Univ Estado Rio De Janeiro, Biomed Ctr, Clin & Expt Res Lab Vasc Biol BioVasc, Rio De Janeiro, Brazil.
   [Clapauch, Ruth] Hosp Lagoa, Female Endocrinol Sect, Minist Hlth, Rio De Janeiro, Brazil.
   [Kraemer-Aguiar, Luiz G.] Univ Estado Rio De Janeiro, Dept Internal Med, Fac Med Sci, Div Endocrinol, Rio De Janeiro, Brazil.
C3 Universidade do Estado do Rio de Janeiro; Universidade do Estado do Rio
   de Janeiro
RP Kraemer-Aguiar, LG (corresponding author), Univ Estado Rio De Janeiro, Biomed Ctr, Clin & Expt Res Lab Vasc Biol BioVasc, Rio De Janeiro, Brazil.
EM gkraemer@ig.com.br
RI Clapauch, Ruth/IUP-4139-2023; Maranhão, Priscila/F-2624-2013; Sicuro,
   Fernando/ABB-5797-2020; Kraemer-Aguiar, Luiz Guilherme/ABG-2833-2022
OI Sicuro, Fernando/0000-0002-2091-1712; Kraemer-Aguiar, Luiz
   Guilherme/0000-0002-3528-5881; Maranhao, Priscila/0000-0002-4804-4999
FU National Research Council of Brazil (CNPq); Agency for Financing
   Research of the State of Rio de Janeiro (FAPERJ)
FX This study was supported by grants from the National Research Council of
   Brazil (CNPq) and the Agency for Financing Research of the State of Rio
   de Janeiro (FAPERJ).
CR Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
   Barrett EJ, 2009, DIABETOLOGIA, V52, P752, DOI 10.1007/s00125-009-1313-z
   Bonetti PO, 2003, ARTERIOSCL THROM VAS, V23, P168, DOI 10.1161/01.ATV.0000051384.43104.FC
   Celermajer DS, 1997, J AM COLL CARDIOL, V30, P325, DOI 10.1016/S0735-1097(97)00189-7
   Chobanian AV, 2003, HYPERTENSION, V42, P1206, DOI 10.1161/01.HYP.0000107251.49515.c2
   Clapauch R, 2012, MENOPAUSE, V19, P672, DOI 10.1097/gme.0b013e31823a8f43
   Clifton VL, 2005, J ENDOCRINOL, V186, P69, DOI 10.1677/joe.1.06030
   Cole TJ, 2000, BMJ-BRIT MED J, V320, P1240, DOI 10.1136/bmj.320.7244.1240
   De Acular LGK, 2006, DIABETES CARE, V29, P1083, DOI 10.2337/dc05-2146
   de Jongh RT, 2004, DIABETES, V53, P2873, DOI 10.2337/diabetes.53.11.2873
   Fichtlscherer S, 2004, CIRCULATION, V110, P1926, DOI 10.1161/01.CIR.0000143378.58099.8C
   Hammer O, 2006, PALEONTOLOGICAL DATA ANALYSIS, P1
   Han KA, 2011, DIABETES-METAB RES, V27, P354, DOI 10.1002/dmrr.1183
   Hsu FC, 2009, J GERONTOL A-BIOL, V64, P581, DOI 10.1093/gerona/glp005
   JACKSON DA, 1993, ECOLOGY, V74, P2204, DOI 10.2307/1939574
   Ketel IJG, 2009, MICROCIRCULATION, V16, P714, DOI 10.3109/10739680903199186
   Klyscz T, 1997, BIOMED TECH, V42, P168, DOI 10.1515/bmte.1997.42.6.168
   de Aguiar LGK, 2007, DIABETIC MED, V24, P272, DOI 10.1111/j.1464-5491.2007.02082.x
   Kraemer-Aguiar LG, 2010, INT J OBESITY, V34, P111, DOI 10.1038/ijo.2009.209
   Kraemer-Aguiar LG, 2010, MICROVASC RES, V80, P427, DOI 10.1016/j.mvr.2010.08.004
   Kraemer-Aguiar LG, 2008, METABOLISM, V57, P1740, DOI 10.1016/j.metabol.2008.07.034
   Manly BFJ., 2017, Multivariate Statistical Methods-A Primer, V4th Ed
   Maranhao PA, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-32
   Nieuwdorp M, 2005, CURR OPIN LIPIDOL, V16, P507, DOI 10.1097/01.mol.0000181325.08926.9c
   Pearson K, 1901, PHILOS MAG, V2, P559, DOI 10.1080/14786440109462720
   Rubio-Gayosso I, 2006, AM J PHYSIOL-HEART C, V290, pH2247, DOI 10.1152/ajpheart.00796.2005
   SAX FL, 1987, NEW ENGL J MED, V317, P1366, DOI 10.1056/NEJM198711263172202
   Serné EH, 1999, CIRCULATION, V99, P896, DOI 10.1161/01.CIR.99.7.896
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Stubbs PJ, 1999, HEART, V82, P443, DOI 10.1136/hrt.82.4.443
   Stubbs PJ, 1999, CLIN SCI, V96, P589, DOI 10.1042/cs0960589
   Taddei S, 2002, DRUGS, V62, P265, DOI 10.2165/00003495-200262020-00003
   Tanner J.M., 1962, Growth at Adolescence, V2nd ed.
   Vogel RA, 1999, AM J MED, V107, P479, DOI 10.1016/S0002-9343(99)00261-2
   Voidonikola PT, 2008, OBESITY, V16, P2658, DOI 10.1038/oby.2008.431
   Wiernsperger N, 2007, MICROCIRCULATION, V14, P403, DOI 10.1080/10739680701285617
   Williams SB, 1998, CIRCULATION, V97, P1695, DOI 10.1161/01.CIR.97.17.1695
   World Health Organization, 1995, WHO TECHN REP SER, V854, P1
   Zimmet P, 2007, PEDIATR DIABETES, V8, P299, DOI 10.1111/j.1399-5448.2007.00271.x
NR 39
TC 14
Z9 16
U1 0
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD NOV 13
PY 2012
VL 12
AR 102
DI 10.1186/1471-2261-12-102
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 062GZ
UT WOS:000312908800001
PM 23148545
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Birarra, MK
   Gelayee, DA
AF Birarra, Mequanent Kassa
   Gelayee, Dessalegn Asmelashe
TI Metabolic syndrome among type 2 diabetic patients in Ethiopia: a
   cross-sectional study
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Article
DE Metabolic syndrome; Type 2 diabetes mellitus; University of Gondar;
   Ethiopia
ID CARDIOVASCULAR-DISEASE; PREVALENCE; RISK; DIAGNOSIS; STRESS; ADULTS
AB Background: Metabolic syndrome (MetS) increases risk of cardiovascular diseases (CVD), premature death as well as cost related to health care. This study was aimed at investigating the prevalence of MetS and its determinant factors among type2 diabetes mellitus (T2DM) patients attending a specialized hospital.
   Methods: A cross-sectional study was conducted on a total of 256 T2DM patients from the first march to 30th May 2017 at university of gondar comprehensive specialized hospital (UGCSH). Data was collected based on STROBE (strengthening the reporting of observational studies in epidemiology) statement. Bivariable and multivariable logistic regression analysis were run to identify predictors of MetS from the independent variables and significance test was set at P < 0.05.
   Results: The prevalence of MetS in this study was 70.3, 57 & 45.3% and it is more common in females (66.1, 83.3 & 70.7%) by using national cholesterol education program adult treatment panel III (NCEP-ATP III), International diabetic federation (IDF) and world health organization (WHO) criteria respectively. The most prevalent components of MetS were low level of high density lipoprotein (HDL) and triglyceride(TG). By usingIDF criteria, female gender was significantly associated with MetS (AOR = 0.2 at 95% CI: 0.1, 0.6 P = 0.00). Where as by NCEP-ATP IIIcriteria, age between 51 and 64 years old (AOR = 2.4 95% CI: 1.0,5.8, P = 0.04), self employment (AOR = 2.7 95% CI: 1.1, 6.5, P = 0. 03), and completetion of secondary school and above (AOR = 3.2, 95% CI: 1.6,6.7, P = 0.001) were predictors for the development of MetS. In the WHO criteria, being single in marital status was significantly associated with MetS (AOR = 17 at 95% CI: 1.8, 166, P = 0.000).
   Conclusions: This study demonstrates that Metabolic syndrome is a major health concern for diabetic patients in Ethiopia and they are at increased risk of developing complications such as cardiovascular diseases and premature mortality. The predictors female gender, age between 51 and 64 years old, urban area residence, and being single are modifiable. Thus, health authorities shall provide targeted interventions such as life style modifications to these most at risk sub-populations of diabetic patients.
C1 [Birarra, Mequanent Kassa] Univ Gondar, Coll Med & Hlth Sci, Sch Pharm, Dept Clin Pharm, Lideta St,POB 196, Gondar, Ethiopia.
   [Gelayee, Dessalegn Asmelashe] Univ Gondar, Coll Med & Hlth Sci, Sch Pharm, Dept Pharmacol, Gondar, Ethiopia.
C3 University of Gondar; University of Gondar
RP Birarra, MK (corresponding author), Univ Gondar, Coll Med & Hlth Sci, Sch Pharm, Dept Clin Pharm, Lideta St,POB 196, Gondar, Ethiopia.
EM mekuanentk@gmail.com
CR Abda E, 2016, DIABETES METAB SYNDR, V9, P47, DOI 10.2147/DMSO.S97561
   Ahmed HM, 2016, AM J EPIDEMIOL, V183, P875, DOI 10.1093/aje/kwv305
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   [Anonymous], 2022, NONCOMMUNICABLE DIS
   [Anonymous], IDF ATL
   Assegu, 2017, HLTH SCI J, V11
   Basol G, 2011, BRATISL MED J, V112, P253
   Bentley-Lewis R, 2007, NAT CLIN PRACT ENDOC, V3, P696, DOI 10.1038/ncpendmet0616
   Borena W, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0089368
   Boudreau DM, 2009, METAB SYNDR RELAT D, V7, P305, DOI 10.1089/met.2008.0070
   Bouguerra R, 2006, DIABETES METAB, V32, P215, DOI 10.1016/S1262-3636(07)70271-9
   BRAY GA, 1989, DM-DIS MON, V35, P451
   Callaghan BC, 2011, DIABETES CARE, V34, P635, DOI 10.2337/dc10-0878
   Chakraborty Sasthi Narayan, 2015, J Family Med Prim Care, V4, P535, DOI 10.4103/2249-4863.174279
   Chandalia M, 2000, NEW ENGL J MED, V342, P1392, DOI 10.1056/NEJM200005113421903
   Charmandari E, 2005, ANNU REV PHYSIOL, V67, P259, DOI 10.1146/annurev.physiol.67.040403.120816
   Chowdhury MZI, 2018, BMC PUBLIC HEALTH, V18, DOI 10.1186/s12889-018-5209-z
   CHROUSOS GP, 1992, JAMA-J AM MED ASSOC, V267, P1244, DOI 10.1001/jama.267.9.1244
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Matheus ASD, 2013, INT J HYPERTENS, V2013, DOI 10.1155/2013/653789
   Devers MC, 2016, BMJ OPEN DIAB RES CA, V4, DOI 10.1136/bmjdrc-2016-000195
   Foroozanfar Z, 2015, IRAN J MED SCI, V40, P522
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Han TS, 2016, JRSM CARDIOVASC DIS, V5, DOI 10.1177/2048004016633371
   Islam SMS, 2014, GLOBALIZATION HEALTH, V10, DOI 10.1186/s12992-014-0081-9
   Kengne AP, 2012, DIABETOL METAB SYNDR, V4, DOI 10.1186/1758-5996-4-22
   Khanam MA, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020259
   Lemogoum D, 2003, J HYPERTENS, V21, P1993, DOI 10.1097/00004872-200311000-00003
   Morimoto A, 2008, TOHOKU J EXP MED, V216, P69, DOI 10.1620/tjem.216.69
   Nijpels Giel, 2016, EPIDEMIOLOGY TYPE 2, DOI [10.14496/dia.3104287123.18, DOI 10.14496/DIA.3104287123.18]
   Nsiah Kwabena, 2015, Int J Appl Basic Med Res, V5, P133, DOI 10.4103/2229-516X.157170
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Panagiotakos DB, 2004, AM HEART J, V147, P106, DOI 10.1016/S0002-8703(03)00442-3
   Pitsavos Christos, 2006, Review of Diabetic Studies, V3, P118, DOI 10.1900/RDS.2006.3.118
   Pokharel DR, 2014, J DIABETES METAB DIS, V13, DOI 10.1186/s40200-014-0104-3
   Pourhoseingholi Mohamad Amin, 2013, Gastroenterol Hepatol Bed Bench, V6, P14
   Rampal S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046365
   Rivellese AA, 2010, NUTR METAB CARDIOVAS, V20, P474, DOI 10.1016/j.numecd.2010.01.008
   Saloojee S, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/s12888-014-0228-5
   Smith SR, 2006, OBESITY, V14, p128S, DOI 10.1038/oby.2006.292
   Thomas G, 2011, CLIN J AM SOC NEPHRO, V6, P2364, DOI 10.2215/CJN.02180311
   Woyesa SB, 2017, BMC ENDOCR DISORD, V17, DOI 10.1186/s12902-017-0226-y
   Yadav Dhananjay, 2013, Glob J Health Sci, V5, P142, DOI 10.5539/gjhs.v5n6p142
NR 44
TC 29
Z9 29
U1 1
U2 18
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD JUL 17
PY 2018
VL 18
AR 149
DI 10.1186/s12872-018-0880-7
PG 12
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GN3SS
UT WOS:000438929000001
PM 30016936
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pizzi, C
   Manfrini, O
   Fontana, F
   Bugiardini, R
AF Pizzi, C
   Manfrini, O
   Fontana, F
   Bugiardini, R
TI Angiotensin-converting enzyme inhibitors and 3-hydroxy-3-methylglutaryl
   coenzyme A reductase in cardiac syndrome X - Role of superoxide
   dismutase activity
SO CIRCULATION
LA English
DT Article
DE syndrome X; endothelium; free radicals
ID NORMAL CORONARY-ARTERIES; CHEST-PAIN; NITRIC-OXIDE; ENDOTHELIAL
   DYSFUNCTION; FLOW RESERVE; DISEASE; ANGINA; VASODILATATION; ANGIOGRAMS;
   MECHANISMS
AB Background - Morbidity of patients with Syndrome X (SX; chest pain and normal coronary angiograms) is high and is associated with continuing episodes of chest pain and hospitalization. Impairment of microvascular endothelial function caused by increased oxidative stress has been suggested to be a mechanism of the disease. Superoxide dismutase ( SOD) is the major antioxidant enzyme system of the vascular wall. This study sought to establish whether combination treatment with ACE inhibitors and statins reduces oxidative stress and improves quality of life of patients with cardiac SX.
   Methods and Results - Forty-five patients with SX were randomly assigned to receive either a combination of ramipril (10 mg/d) and atorvastatin ( 40 mg/d) or placebo for 6 months. We determined the activity of extracellular SOD and its relation to flow-dependent endothelium-mediated dilation (FMD) and quality of life ( exercise capacity and score with Seattle Angina Questionnaire [SAQ]) before and after treatment. After 6 months, patients with SX who received atorvastatin and ramipril had significantly reduced ( P = 0.001) SOD levels (188.1 +/- 29.6 U/mL). No significant changes were seen on placebo (262.9 +/- 48.8 U/mL). Reduction of SOD after therapy was negatively correlated with FMD (r = 0.38; P = 0.01) and positively with total cholesterol (r = - 0.56; P < 0.001). At follow-up, patients taking atorvastatin and ramipril improved their quality of life both in terms of exercise duration (by 23.46%) and SAQ (by 64.1%).
   Conclusions - Six months of therapy with atorvastatin and ramipril improves endothelial function and quality of life of patients with SX. Reduced SOD activity may reflect low superoxide anion production. Benefits of these drugs may be related to reduction of oxidative stress.
C1 Univ Bologna, Dipartimento Med Interna, I-40138 Bologna, Italy.
C3 University of Bologna
RP Bugiardini, R (corresponding author), Univ Bologna, Dipartimento Med Interna, Via Massarenti 9, I-40138 Bologna, Italy.
RI PIZZI, Carmine/C-8394-2012; MANFRINI, OLIVIA/AAM-9442-2020; Bugiardini,
   Raffaele/L-6446-2015
OI Bugiardini, Raffaele/0000-0002-6819-6818; Pizzi,
   Carmine/0000-0002-4048-675X
CR Albertsson P, 1997, AM J CARDIOL, V79, P299, DOI 10.1016/S0002-9149(96)00751-5
   Bugiardini R, 1993, J AM COLL CARDIOL, V22, P417, DOI 10.1016/0735-1097(93)90045-3
   Cai H, 2000, CIRC RES, V87, P840, DOI 10.1161/01.RES.87.10.840
   CANNON RO, 1990, J AM COLL CARDIOL, V16, P1359, DOI 10.1016/0735-1097(90)90377-2
   Cannon RO, 2000, NEW ENGL J MED, V342, P885, DOI 10.1056/NEJM200003233421209
   CANNON RO, 1991, CIRCULATION, V83, P77
   Chen JW, 2002, AM J CARDIOL, V90, P974, DOI 10.1016/S0002-9149(02)02664-4
   Corretti MC, 2002, J AM COLL CARDIOL, V39, P257, DOI 10.1016/S0735-1097(01)01746-6
   Desideri G, 2000, CIRCULATION, V102, P2359, DOI 10.1161/01.CIR.102.19.2359
   EGASHIRA K, 1993, NEW ENGL J MED, V328, P1659, DOI 10.1056/NEJM199306103282302
   GE JB, 1994, BRIT HEART J, V71, P572
   Gewaltig MT, 2002, CARDIOVASC RES, V55, P250, DOI 10.1016/S0008-6363(02)00327-9
   GRIENDLING KK, 1994, CIRC RES, V74, P1141, DOI 10.1161/01.RES.74.6.1141
   KOMARU T, 1990, CIRC RES, V67, P1142, DOI 10.1161/01.RES.67.5.1142
   Landmesser U, 2000, CIRCULATION, V101, P2264, DOI 10.1161/01.CIR.101.19.2264
   MCCORD JM, 1969, J BIOL CHEM, V244, P6049
   MISRA HP, 1972, J BIOL CHEM, V247, P3170
   Montori VM, 2002, J CLIN EPIDEMIOL, V55, P787, DOI 10.1016/S0895-4356(02)00446-8
   MUGGE A, 1991, AM J PHYSIOL, V260, pC219, DOI 10.1152/ajpcell.1991.260.2.C219
   Nikolaidis LA, 2002, CIRCULATION, V105, P2785, DOI 10.1161/01.CIR.0000017433.90061.2E
   Panting JR, 2002, NEW ENGL J MED, V346, P1948, DOI 10.1056/NEJMoa012369
   Panza JA, 2002, NEW ENGL J MED, V346, P1934, DOI 10.1056/NEJMp020047
   Panza JA, 1997, J AM COLL CARDIOL, V29, P293, DOI 10.1016/S0735-1097(96)00481-0
   QUYYUMI AA, 1992, CIRCULATION, V86, P1864, DOI 10.1161/01.CIR.86.6.1864
   SPERTUS JA, 1995, J AM COLL CARDIOL, V25, P333, DOI 10.1016/0735-1097(94)00397-9
   Tousoulis D, 2001, CLIN CARDIOL, V24, P301, DOI 10.1002/clc.4960240409
   VANE JR, 1990, NEW ENGL J MED, V323, P27
   Wagner AH, 2000, ARTERIOSCL THROM VAS, V20, P61, DOI 10.1161/01.ATV.20.1.61
NR 28
TC 147
Z9 152
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD JAN 6
PY 2004
VL 109
IS 1
BP 53
EP 58
DI 10.1161/01.CIR.0000100722.34034.E4
PG 6
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 760BY
UT WOS:000187791900013
PM 14699004
OA Bronze
DA 2025-06-11
ER

PT J
AU Jibril, AT
   Jayedi, A
   Shab-Bidar, S
AF Jibril, Aliyu Tijani
   Jayedi, Ahmad
   Shab-Bidar, Sakineh
TI Efficacy and safety of oral alpha-lipoic acid supplementation for type 2
   diabetes management: a systematic review and dose-response meta-analysis
   of randomized trials
SO ENDOCRINE CONNECTIONS
LA English
DT Review
DE alpha-lipoic acid; cardiometabolic; type 2 diabetes; diabetes;
   systematic review; meta-analysis
ID CARDIAC AUTONOMIC NEUROPATHY; OXIDATIVE-STRESS; GLUCOSE-UPTAKE;
   ANTIOXIDANT; ACTIVATION; MELLITUS; ALA; WEIGHT; NIDDM
AB Objective: To examine the dose-dependent influence of oral alpha-lipoic acid (ALA) supplementation on cardiometabolic risk factors in patients with type 2 diabetes (T2D).
   Design: We followed the instructions outlined in the Cochrane Handbook for Systematic Reviews of Interventions and the Grading of Recommendations, Assessment, Development, and Evaluation Handbook to conduct our systematic review. The protocol of the study was registered in PROSPERO (CRD42021260587).
   Method: We searched PubMed, Scopus, and Web of Science to May 2021 for trials of oral ALA supplementation in adults with T2D. The primary outcomes were HbA1c, weight loss, and LDL cholesterol (LDL-C). Secondary outcomes included fasting plasma glucose (FPG), triglyceride (TG), C-reactive protein (CRP), and blood pressure. We conducted a random-effects dose-response meta-analysis to calculate the mean difference (MD) and 95% CI for each 500 mg/day oral ALA supplementation. We performed a nonlinear dose-response meta-analysis using a restricted cubic spline.
   Results: We included 16 trials with 1035 patients. Each 500 mg/day increase in oral ALA supplementation significantly reduced HbA1c, body weight, CRP, FPG, and TG. Dose-response meta-analyses indicated a linear decrement in body weight at ALA supplementation of more than 600 mg/day (MD600 (mg/day): -0.30 kg, 95% CI: -0.04, -0.57). A relatively J-shaped effect was seen for HbA1c (MD: -0.32%, 95% CI: -0.45, -0.18). Levels of FPG and LDL-C decreased up to 600 mg/day ALA intake. The point estimates were below minimal clinically important difference thresholds for all outcomes.
   Conclusion: Despite significant improvements, the effects of oral ALA supplementation on cardiometabolic risk factors in patients with T2D were not clinically important.
C1 [Jibril, Aliyu Tijani; Shab-Bidar, Sakineh] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Jayedi, Ahmad] Semnan Univ Med Sci, Social Determinants Hlth Res Ctr, Semnan, Iran.
C3 Tehran University of Medical Sciences; Semnan University of Medical
   Sciences
RP Shab-Bidar, S (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
EM s_shabbidar@tums.ac.ir
RI Jayedi, Ahmad/E-7237-2017; Shab-Bidar, Sakineh/H-9525-2017; Jibril,
   Aliyu Tijani/AAF-4695-2021
OI Jibril, Aliyu Tijani/0000-0003-3930-9091
CR Adnan Khalaf M, 2021, Arch Razi Inst, V76, P1453, DOI 10.22092/ari.2021.355755.1717
   Akbari M, 2018, NUTR METAB, V15, DOI 10.1186/s12986-018-0274-y
   Al-Saber F, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/8294805
   Ansar H, 2011, SAUDI MED J, V32, P584
   Barbiroli B., 1996, DIABETES STOFFWECHSE, V5, P71
   Bashan N, 2009, PHYSIOL REV, V89, P27, DOI 10.1152/physrev.00014.2008
   Baziar N, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/5850865
   Begg C. B., 1994, The handbook of research synthesis, V25, P299
   Brozek JL, 2009, ALLERGY, V64, P669, DOI 10.1111/j.1398-9995.2009.01973.x
   Chang JW, 2007, AM J NEPHROL, V27, P70, DOI 10.1159/000099035
   Choi SH, 2011, TRENDS ENDOCRIN MET, V22, P353, DOI 10.1016/j.tem.2011.04.007
   COHEN J, 1960, EDUC PSYCHOL MEAS, V20, P37, DOI 10.1177/001316446002000104
   Crippa A, 2016, BMC MED RES METHODOL, V16, DOI 10.1186/s12874-016-0189-0
   de Oliveira AM, 2011, DIABETES RES CLIN PR, V92, P253, DOI 10.1016/j.diabres.2011.02.010
   Derosa G, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17111802
   DERSIMONIAN R, 1986, CONTROL CLIN TRIALS, V7, P177, DOI 10.1016/0197-2456(86)90046-2
   Didangelos T, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113254
   Ebada MA, 2019, IRAN J PHARM RES, V18, P2144, DOI 10.22037/ijpr.2019.1100842
   Egger M, 1997, BMJ-BRIT MED J, V315, P629, DOI 10.1136/bmj.315.7109.629
   Estrada DE, 1996, DIABETES, V45, P1798, DOI 10.2337/diabetes.45.12.1798
   Fernández-Galilea M, 2014, OBESITY, V22, P2210, DOI 10.1002/oby.20846
   Fernández-Galilea M, 2012, J LIPID RES, V53, P2296, DOI 10.1194/jlr.M027086
   Furukawa TA, 2006, J CLIN EPIDEMIOL, V59, P7, DOI 10.1016/j.jclinepi.2005.06.006
   Gianturco V, 2009, ARCH GERONTOL GERIAT, V49, P129, DOI 10.1016/j.archger.2009.09.022
   Golbidi S, 2011, FRONT PHARMACOL, V2, DOI 10.3389/fphar.2011.00069
   Goldenberg JZ, 2021, BMJ-BRIT MED J, V372, DOI 10.1136/bmj.m4743
   Haghighatdoost F, 2019, EUR J PHARMACOL, V849, P115, DOI 10.1016/j.ejphar.2019.01.065
   Haghighatdoost F, 2019, EUR J PHARMACOL, V847, P1, DOI 10.1016/j.ejphar.2019.01.001
   Harrell FE, 2015, SPRINGER SER STAT, DOI 10.1007/978-3-319-19425-7
   Higgins JPT, 2003, BMJ-BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557
   Hofmann MA, 1999, DIABETOLOGIA, V42, P222, DOI 10.1007/s001250051142
   Kaneto H, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/453892
   Kim MS, 2004, NAT MED, V10, P727, DOI 10.1038/nm1061
   Koh EH, 2011, AM J MED, V124, DOI 10.1016/j.amjmed.2010.08.005
   Konrad D, 2005, ANTIOXID REDOX SIGN, V7, P1032, DOI 10.1089/ars.2005.7.1032
   Konrad D, 2001, DIABETES, V50, P1464, DOI 10.2337/diabetes.50.6.1464
   Kucukgoncu S, 2017, OBES REV, V18, P594, DOI 10.1111/obr.12528
   Kumar S, 2021, CURR DIABETES REV, V17, P437, DOI 10.2174/1573399816666201103143225
   Lee SJ, 2017, DIABETES METAB J, V41, P275, DOI 10.4093/dmj.2017.41.4.275
   Lee WJ, 2005, BIOCHEM BIOPH RES CO, V332, P885, DOI 10.1016/j.bbrc.2005.05.035
   Li N, 2017, CLIN ENDOCRINOL, V86, P680, DOI 10.1111/cen.13303
   Lukaszuk JM., 2009, J COMPLEMENT INTEGRA, V6, DOI [10.2202/1553-3840.1297, DOI 10.2202/1553-3840.1297]
   Luo DH, 2018, STAT METHODS MED RES, V27, P1785, DOI 10.1177/0962280216669183
   Mendoza-Núñez VM, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/3276958
   Marseglia L, 2015, INT J MOL SCI, V16, P378, DOI 10.3390/ijms16010378
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Mohsen IH, 2022, Journal of Chemical Health Risks, V12, P523, DOI 10.22034/JCHR.2022.690774
   Moini H, 2002, ARCH BIOCHEM BIOPHYS, V397, P384, DOI 10.1006/abbi.2001.2680
   Mousavi SM, 2019, NUTRITION, V59, P121, DOI 10.1016/j.nut.2018.08.004
   Naghavi M., 2015, LANCET, V385, P117, DOI DOI 10.1016/S0140-6736(14)61682-2
   Nasser M, 2020, AM J PUBLIC HEALTH, V110, P753, DOI 10.2105/AJPH.2020.305609
   Okanovic Azra, 2015, Med Glas (Zenica), V12, P122, DOI 10.17392/798-15
   PACKER L, 1995, FREE RADICAL BIO MED, V19, P227, DOI 10.1016/0891-5849(95)00017-R
   Packer L, 1998, DRUG METAB REV, V30, P245, DOI 10.3109/03602539808996311
   Patle D, 2021, CURR DIABETES REV, V17, P186, DOI 10.2174/1573399816666200408090058
   Porasuphatana S, 2012, ASIA PAC J CLIN NUTR, V21, P12
   Rahimlou M, 2019, CLIN NUTR ESPEN, V32, P16, DOI 10.1016/j.clnesp.2019.03.015
   Saengsirisuwan V, 2001, J APPL PHYSIOL, V91, P145, DOI 10.1152/jappl.2001.91.1.145
   Schandelmaier S, 2020, CAN MED ASSOC J, V192, pE901, DOI 10.1503/cmaj.200077
   Schunemann H., 2008, GRADE handbook for grading quality of evidence and strength of recommendation
   Shay KP, 2009, BBA-GEN SUBJECTS, V1790, P1149, DOI 10.1016/j.bbagen.2009.07.026
   Shin JA, 2013, J DIABETES INVEST, V4, P334, DOI 10.1111/jdi.12075
   Sun YD, 2012, ANN NUTR METAB, V60, P293, DOI 10.1159/000338444
   Tabrizi R, 2019, J DIABETES METAB DIS, V18, P585, DOI 10.1007/s40200-019-00423-0
   Tibullo D, 2017, INFLAMM RES, V66, P947, DOI 10.1007/s00011-017-1079-6
   Udupa A, 2013, ANN MED HEALTH SCI R, V3, P442, DOI 10.4103/2141-9248.117954
   Ung L, 2019, J APPL BIOPHARM PHAR, V7, P1
   Wan X, 2014, BMC MED RES METHODOL, V14, DOI 10.1186/1471-2288-14-135
   Zhang WJ, 2001, FASEB J, V15, P2423, DOI 10.1096/fj.01-0260com
   Ziegler D, 1997, DIABETES CARE, V20, P369, DOI 10.2337/diacare.20.3.369
NR 70
TC 7
Z9 7
U1 0
U2 2
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
EI 2049-3614
J9 ENDOCR CONNECT
JI Endocr. Connect.
PD OCT 1
PY 2022
VL 11
IS 10
AR e220322
DI 10.1530/EC-22-0322
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 5K4SF
UT WOS:000869716800006
PM 36006850
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hristov, BD
AF Hristov, Boris D.
TI The Role of Glutathione Metabolism in Chronic Illness Development and
   Its Potential Use as a Novel Therapeutic Target
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE atherosclerotic cardiovascular disease; neurodegenerative disesase;
   chronic liver disease (cld); chronic renal disease; metabolic syndrome;
   ggt; n-acetylcysteine; glutathione
ID INTRAVENOUS N-ACETYLCYSTEINE; GAMMA-GLUTAMYL-TRANSFERASE; OXIDATIVE
   STRESS; CARDIOVASCULAR-DISEASE; ACETYL-CYSTEINE; RISK; TRANSPEPTIDASE;
   HOMOCYSTEINE; MULTICENTER; ELEVATION
AB Glutathione (GSH) is the most abundant thiol antioxidant in the human body and serves many important biochemical functions, including the regulation of vitamins, such as vitamins D, E, and C, and detoxification of drugs and toxins. As a powerful antioxidant, GSH is particularly important as a regulator of mitochondrial metabolism and a free radical scavenger that limits oxidative damage to cellular components. Low GSH levels have been associated with many chronic pro-inflammatory conditions, such as metabolic syndrome, cardiovascular, renal, and hepatic disease, as well as neurodegenerative conditions and autoimmune diseases. Given GSH's known direct protective role in mitochondrial metabolism and its association with chronic diseases of highly metabolically active tissues, this review aims to examine the literature for evidence that low GSH levels may be an important causative factor in the development of chronic illnesses. Because no large prospective human trials have been conducted using direct measurements of GSH, this review focused on the more common biomarker gamma-glutamyl transferase (GGT) which is directly correlated to low GSH levels. Several large prospective studies support this hypothesis by demonstrating that higher GGT levels are correlated with the risk of developing metabolic syndrome and cardiovascular disease in a dose-dependent fashion. Furthermore, as a corollary to this hypothesis, human and animal trials utilizing GSH augmentation using precursor supplementation in chronic conditions, including metabolic syndrome, cardiovascular disease, hepatic disease, renal disease, and neurodegenerative conditions, were also reviewed. While many of these trials were preliminary and small, there is strong evidence that GSH supplementation leads to improved outcomes in all of these chronic conditions. This review seeks to highlight these studies as preliminary evidence demonstrating the contributory role of GSH in chronic disease progression because a simple and cost-effective strategy can be created to screen for, track, and intervene in susceptible patients in the primary care setting at the earliest possible time in the disease process. Such a novel strategy would impact the majority of chronic diseases contributing to the bulk of morbidity and mortality in the Western world, and, thus, even minor benefits across many conditions may substantially impact population-wide health and longevity.
C1 [Hristov, Boris D.] Brookdale Univ Hosp Med Ctr, Surg Crit Care & Acute Care Surg, New York, NY 11212 USA.
RP Hristov, BD (corresponding author), Brookdale Univ Hosp Med Ctr, Surg Crit Care & Acute Care Surg, New York, NY 11212 USA.
EM bhristov10@gmail.com
CR Adair JC, 2001, NEUROLOGY, V57, P1515, DOI 10.1212/WNL.57.8.1515
   Ahmadi F, 2017, CLIN EXP NEPHROL, V21, P342, DOI 10.1007/s10157-016-1277-5
   Akaydin SY, 2020, EUR J BREAST HEALTH, V16, P72, DOI 10.5152/ejbh.2019.5147
   Alnandi A, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10020239
   Amore A, 2013, J NEPHROL, V26, P778, DOI 10.5301/jn.5000167
   Amrein K, 2014, JAMA-J AM MED ASSOC, V312, P1520, DOI 10.1001/jama.2014.13204
   Ben-Shachar R, 2012, THEOR BIOL MED MODEL, V9, DOI 10.1186/1742-4682-9-55
   Berk M, 2008, BIOL PSYCHIAT, V64, P361, DOI 10.1016/j.biopsych.2008.03.004
   Bjorklund G, 2021, NEUROSCI BIOBEHAV R, V120, P470, DOI 10.1016/j.neubiorev.2020.10.004
   CeballosPicot I, 1996, FREE RADICAL BIO MED, V21, P845, DOI 10.1016/0891-5849(96)00233-X
   Cui YQ, 2015, SCI REP-UK, V5, DOI 10.1038/srep16339
   Di Giorno C, 2006, TRANSPL P, V38, P2774, DOI 10.1016/j.transproceed.2006.08.178
   Dunning S, 2013, BBA-MOL BASIS DIS, V1832, P2027, DOI 10.1016/j.bbadis.2013.07.008
   FINE A, 1975, SCOT MED J, V20, P113, DOI 10.1177/003693307502000309
   Garg G, 2018, CAN J PHYSIOL PHARM, V96, P1189, DOI 10.1139/cjpp-2018-0209
   Giannikouris I, 2015, HIPPOKRATIA, V19, P131
   HAMMARSTROM S, 1983, ANNU REV BIOCHEM, V52, P355, DOI 10.1146/annurev.bi.52.070183.002035
   HAYDEN RE, 1987, LARYNGOSCOPE, V97, P1176
   Jain SK, 2018, ANTIOXID REDOX SIGN, V29, P1792, DOI 10.1089/ars.2017.7462
   Kaplowitz N, 2004, HEPATOLOGY, V40, P23, DOI 10.1002/hep.20312
   Kennedy L, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10101429
   Khoshbaten M, 2010, HEPAT MON, V10, P12
   Kumar P, 2021, CLIN TRANSL MED, V11, DOI 10.1002/ctm2.372
   Lapenna D, 1998, CIRCULATION, V97, P1930, DOI 10.1161/01.CIR.97.19.1930
   Lee DS, 2007, ARTERIOSCL THROM VAS, V27, P127, DOI 10.1161/01.ATV.0000251993.20372.40
   Lee TM, 2021, AUST NZ J PSYCHIAT, V55, P196, DOI 10.1177/0004867420952540
   Lee WM, 2009, GASTROENTEROLOGY, V137, P856, DOI 10.1053/j.gastro.2009.06.006
   Lutchmansingh FK, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0198626
   Mak TW, 2017, IMMUNITY, V46, P675, DOI 10.1016/j.immuni.2017.03.019
   Marian AJ, 2018, CIRC RES, V122, P1109, DOI 10.1161/CIRCRESAHA.117.312647
   Mischley LK, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/9409363
   Monami M, 2008, METABOLISM, V57, P387, DOI 10.1016/j.metabol.2007.10.015
   Monti DA, 2019, CLIN PHARMACOL THER, V106, P884, DOI 10.1002/cpt.1548
   Moreno-Sánchez R, 2018, BBA-BIOENERGETICS, V1859, P1138, DOI 10.1016/j.bbabio.2018.07.008
   Morris D, 2014, FRONT PHARMACOL, V5, DOI 10.3389/fphar.2014.00073
   Nabi T, 2017, SAUDI J GASTROENTERO, V23, P169, DOI 10.4103/1319-3767.207711
   Ndrepepa G, 2018, CLIN CHIM ACTA, V476, P130, DOI 10.1016/j.cca.2017.11.026
   Nuhu F, 2020, MOLECULES, V25, DOI 10.3390/molecules25184196
   Owen JB, 2010, METHODS MOL BIOL, V648, P269, DOI 10.1007/978-1-60761-756-3_18
   Ozaras R, 2003, WORLD J GASTROENTERO, V9, P125, DOI 10.3748/wjg.v9.i1.125
   Palmier James, 2012, J Insur Med, V43, P162
   Paschalis V, 2018, FREE RADICAL BIO MED, V115, P271, DOI 10.1016/j.freeradbiomed.2017.12.007
   Pasupathy S, 2017, CIRCULATION, V136, P894, DOI 10.1161/CIRCULATIONAHA.117.027575
   Perricone C, 2009, AUTOIMMUN REV, V8, P697, DOI 10.1016/j.autrev.2009.02.020
   Pinkham C Allen, 2009, J Insur Med, V41, P170
   PRESCOTT LF, 1974, LANCET, V1, P588, DOI 10.1016/s0140-6736(74)92649-x
   Rani M, 2020, METAB SYNDR RELAT D, V18, P341, DOI 10.1089/met.2020.0017
   Sedlak TW, 2019, P NATL ACAD SCI USA, V116, P2701, DOI 10.1073/pnas.1817885116
   Sekhar RV, 2011, DIABETES CARE, V34, P162, DOI 10.2337/dc10-1006
   Sharma S, 2016, PLANT SCI, V250, P20, DOI 10.1016/j.plantsci.2016.05.013
   SIAN J, 1994, ANN NEUROL, V36, P348, DOI 10.1002/ana.410360305
   SMILKSTEIN MJ, 1988, NEW ENGL J MED, V319, P1557, DOI 10.1056/NEJM198812153192401
   Subramaniam RM, 2016, ANN INTERN MED, V164, P406, DOI 10.7326/M15-1456
   Thaha M, 2006, CLIN DRUG INVEST, V26, P195, DOI 10.2165/00044011-200626040-00003
   Tsai JP, 2010, TZU CHI MED J, V22, P90, DOI 10.1016/S1016-3190(10)60047-X
   Vairetti M, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10030364
   Wang ML, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.724224
   Wei ZX, 2018, FRONT MOL NEUROSCI, V11, DOI 10.3389/fnmol.2018.00236
   WINKLER BS, 1986, EXP EYE RES, V43, P829, DOI 10.1016/S0014-4835(86)80013-6
   Wu XY, 2014, MOL MED REP, V10, P615, DOI 10.3892/mmr.2014.2292
   Zhang HQ, 2005, METHOD ENZYMOL, V401, P468, DOI 10.1016/S0076-6879(05)01028-1
NR 61
TC 18
Z9 19
U1 0
U2 5
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD SEP 28
PY 2022
VL 14
IS 9
AR e29696
DI 10.7759/cureus.29696
PG 8
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA 6J0PB
UT WOS:000886529200045
PM 36321012
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Laurent, MR
   Cook, MJ
   Gielen, E
   Ward, KA
   Antonio, L
   Adams, JE
   Decallonne, B
   Bartfai, G
   Casanueva, FF
   Forti, G
   Giwercman, A
   Huhtaniemi, IT
   Kula, K
   Lean, MEJ
   Lee, DM
   Pendleton, N
   Punab, M
   Claessens, F
   Wu, FCW
   Vanderschueren, D
   Pye, SR
   O'Neill, TW
AF Laurent, M. R.
   Cook, M. J.
   Gielen, E.
   Ward, K. A.
   Antonio, L.
   Adams, J. E.
   Decallonne, B.
   Bartfai, G.
   Casanueva, F. F.
   Forti, G.
   Giwercman, A.
   Huhtaniemi, I. T.
   Kula, K.
   Lean, M. E. J.
   Lee, D. M.
   Pendleton, N.
   Punab, M.
   Claessens, F.
   Wu, F. C. W.
   Vanderschueren, D.
   Pye, S. R.
   O'Neill, T. W.
CA EMAS Grp
TI Lower bone turnover and relative bone deficits in men with metabolic
   syndrome: a matter of insulin sensitivity? The European Male Ageing
   Study
SO OSTEOPOROSIS INTERNATIONAL
LA English
DT Article
DE Bone mineral density; Bone turnover; Male; Metabolic syndrome; Obesity;
   Peripheral quantitative computed tomography
ID BODY-MASS INDEX; FRACTURE RISK; MINERAL DENSITY; SEX STEROIDS;
   ELDERLY-MEN; OLDER MEN; WOMEN; ASSOCIATION; COHORT; HEALTH
AB We examined cross-sectional associations of metabolic syndrome and its components with male bone turnover, density and structure. Greater bone mass in men with meta-bolic syndrome was related to their greater body mass, whereas hyperglycaemia, hypertriglyceridaemia or impaired insulin sensitivity were associated with lower bone turnover and relative bone mass deficits.
   Introduction Metabolic syndrome (MetS) has been associated with lower bone turnover and relative bone mass or strength deficits (i.e. not proportionate to body mass index, BMI), but the relative contributions of MetS components related to insulin sensitivity or obesity to male bone health remain unclear.
   Methods We determined cross-sectional associations of MetS, its components and insulin sensitivity (by homeostatic model assessment-insulin sensitivity (HOMA-S)) using linear regression models adjusted for age, centre, smoking, alcohol, and BMI. Bone turnover markers and heel broadband ultrasound attenuation (BUA) were measured in 3129 men aged 40-79. Two centres measured total hip, femoral neck, and lumbar spine areal bone mineral density (aBMD, n = 527) and performed radius peripheral quantitative computed tomography (pQCT, n = 595).
   Results MetS was present in 975 men (31.2 %). Men with MetS had lower beta C-terminal cross-linked telopeptide (beta-CTX), N-terminal propeptide of type I procollagen (PINP) and osteocalcin (P < 0.0001) and higher total hip, femoral neck, and lumbar spine aBMD (P = 0.03). Among MetS components, only hypertriglyceridaemia and hyperglycaemia were independently associated with PINP and beta-CTX. Hyperglycaemia was negatively associated with BUA, hypertriglyceridaemia with hip aBMD and radius cross-sectional area (CSA) and stress-strain index. HOMA-S was similarly associated with PINP and beta-CTX, BUA, and radius CSA in BMI-adjusted models.
   Conclusions Men with MetS have higher aBMD in association with their greater body mass, while their lower bone turnover and relative deficits in heel BUA and radius CSA are mainly related to correlates of insulin sensitivity. Our findings support the hypothesis that underlying metabolic complications may be involved in the bone's failure to adapt to increasing bodily loads in men with MetS.
C1 [Laurent, M. R.; Gielen, E.] Katholieke Univ Leuven, Dept Clin & Expt Med, Gerontol & Geriatr, Herestr 49,POB 7003, B-3000 Leuven, Belgium.
   [Laurent, M. R.; Antonio, L.] Katholieke Univ Leuven, Dept Cellular & Mol Med, Mol Endocrinol Lab, Herestr 49,POB 901, B-3000 Leuven, Belgium.
   [Laurent, M. R.; Gielen, E.] Univ Hosp Leuven, Ctr Metab Bone Dis, Herestr 49, B-3000 Leuven, Belgium.
   [Cook, M. J.; Pye, S. R.; O'Neill, T. W.] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Med & Human Sci, Inst Inflammat & Repair,Arthrit Res UK Ctr Epidem, Stopford Bldg,Oxford Rd, Manchester M13 9PT, Lancs, England.
   [Ward, K. A.] Med Res Council Human Nutr Res, Elsie Widdowson Lab, 120 Fulbourn Rd, Cambridge CB1 9NL, England.
   [Antonio, L.; Decallonne, B.] Katholieke Univ Leuven, Dept Clin & Expt Med, Clin & Expt Endocrinol, Herestr 49,POB 902, B-3000 Leuven, Belgium.
   [Adams, J. E.] Cent Manchester Univ, Hosp NHS Fdn Trust, Dept Radiol, 46 Grafton St, Manchester M13 9NT, Lancs, England.
   [Adams, J. E.] Cent Manchester Univ, Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester Royal Infirm, 46 Grafton St, Manchester M13 9NT, Lancs, England.
   [Adams, J. E.] Univ Manchester, 46 Grafton St, Manchester M13 9NT, Lancs, England.
   [Bartfai, G.] Albert Szent Gyorgyi Med Univ, Dept Obstet Gynecol & Androl, Semmelweis U 1, H-6725 Szeged, Hungary.
   [Casanueva, F. F.] Univ Santiago Compostela, Dept Med, Complejo Hosp Univ Santiago, CIBER Fisiopatol Obesidad & Nut,Inst Salud Carlos, Travesia Choupana S-N, Santiago De Compostela 15706, Spain.
   [Forti, G.] Univ Florence, Dept Clin Physiopathol, Androl Unit, Viale Pieraccini 6, I-50139 Florence, Italy.
   [Giwercman, A.] Lund Univ, Malmo Univ Hosp, Scanian Androl Ctr, Dept Urol, Jan Waldenstromsgata 35, S-20502 Malmo, Sweden.
   [Huhtaniemi, I. T.] Imperial Coll London, Dept Surg & Canc, Inst Reprod & Dev Biol, Hammersmith Campus, London W12 0HS, England.
   [Kula, K.] Med Univ Lodz, Dept Androl & Reprod Endocrinol, Pomorska 45-47, PL-90406 Lodz, Poland.
   [Lean, M. E. J.] Univ Glasgow, Glasgow Royal Infirm, Dept Human Nutr, Sch Med, Glasgow G31 2ER, Lanark, Scotland.
   [Lee, D. M.] Univ Manchester, Sch Social Sci, Cathie Marsh Inst Social Res, Humanities Bridgeford St G17, Manchester M13 9PL, Lancs, England.
   [Pendleton, N.] Univ Manchester, Sch Community Based Med, Salford Royal NHS Trust, Stott Lane, Salford M6 8HD, Lancs, England.
   [Punab, M.] Tartu Univ Clin, United Labs, Androl Unit, L Puusepa 1a, Tartu, Estonia.
   [Wu, F. C. W.] Univ Manchester, Manchester Royal Infirm, Manchester Acad Hlth Sci Ctr, Androl Res Unit,Dev & Regenerat Biomed Res, Grafton St, Manchester M13 9WL, Lancs, England.
   [O'Neill, T. W.] NIHR Manchester Musculoskeletal Biomed Res Unit, 29 Grafton St, Manchester M13 9WU, Lancs, England.
C3 KU Leuven; KU Leuven; KU Leuven; University Hospital Leuven; University
   of Manchester; University of Cambridge; UK Research & Innovation (UKRI);
   Medical Research Council UK (MRC); MRC Human Nutrition Research; KU
   Leuven; University of Manchester; University of Manchester; Szeged
   University; Universidade de Santiago de Compostela; Complexo
   Hospitalario Universitario de Santiago de Compostela; University of
   Florence; Lund University; Skane University Hospital; Imperial College
   London; Medical University Lodz; University of Glasgow; University of
   Manchester; University of Manchester; Salford Royal NHS Foundation
   Trust; University of Tartu; University of Manchester
RP Laurent, MR (corresponding author), Katholieke Univ Leuven, Dept Clin & Expt Med, Gerontol & Geriatr, Herestr 49,POB 7003, B-3000 Leuven, Belgium.; Laurent, MR (corresponding author), Katholieke Univ Leuven, Dept Cellular & Mol Med, Mol Endocrinol Lab, Herestr 49,POB 901, B-3000 Leuven, Belgium.; Laurent, MR (corresponding author), Univ Hosp Leuven, Ctr Metab Bone Dis, Herestr 49, B-3000 Leuven, Belgium.
EM michael.laurent@med.kuleuven.be
RI Kujala, Urho/AAP-2547-2020; Woo, Jean/K-2625-2014; Ward,
   Katherine/HKV-3840-2023; , Margus Punab/KXS-1159-2024; Laurent,
   Michael/D-5748-2011; Claessens, Frank/M-8565-2016; Pendleton,
   Neil/F-2333-2015; Antonio, Leen/T-1206-2018; Lee, David/D-1005-2009;
   Gielen, Evelien/L-6604-2018; Pye, Stephen/D-9236-2011
OI Laurent, Michael/0000-0001-9681-8330; Decallonne,
   Brigitte/0000-0003-4153-4757; Ward, Kate/0000-0001-7034-6750; Claessens,
   Frank/0000-0002-8676-7709; Pendleton, Neil/0000-0003-0794-2386; Cook,
   Michael/0000-0002-6551-9722; Antonio, Leen/0000-0002-1079-2860; Punab,
   Margus/0000-0001-9601-6311; Lee, David/0000-0003-3472-0789; Gielen,
   Evelien/0000-0002-8985-1201; vanderschueren, dirk/0000-0003-1395-0104;
   Pye, Stephen/0000-0002-7263-2897
FU Commission of the European Communities Fifth Framework Programme,
   Quality of Life and Management of Living Resources [QLK6-CT-2001-00258];
   Arthritis Research UK; Research Foundation Flanders [G.0171.03,
   G.0854.13N]; KU Leuven [GOA/15/017]; UK National Institute for Health
   Research Biomedical Research Unit Funding Scheme; UK Medical Research
   Council [U105960371]; University Hospitals Leuven, Belgium; MRC
   [MC_U105960371] Funding Source: UKRI
FX The European Male Ageing Study was funded by the Commission of the
   European Communities Fifth Framework Programme, Quality of Life and
   Management of Living Resources, Grant QLK6-CT-2001-00258, by Arthritis
   Research UK, by the Research Foundation Flanders grants G.0171.03 and
   G.0854.13N and KU Leuven grant GOA/15/017. This report includes
   independent research supported by the UK National Institute for Health
   Research Biomedical Research Unit Funding Scheme. The views expressed in
   this publication are those of the author(s) and not necessarily those of
   the NHS, the National Institute for Health Research or the Department of
   Health. The work of K.A.W. was conducted within the core programme of
   the MRC Nutrition and Bone Health Group at MRC Human Nutrition Research,
   funded by the UK Medical Research Council (Programme number U105960371).
   M.R.L. is a PhD Fellow of the Research Foundation Flanders. D.V. is a
   senior clinical investigator supported by the Clinical Research Fund of
   the University Hospitals Leuven, Belgium.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Antonio L, 2015, J CLIN ENDOCR METAB, V100, P1396, DOI 10.1210/jc.2014-4184
   Boonen S, 2011, EUR J ENDOCRINOL, V165, P977, DOI 10.1530/EJE-11-0353
   Chan MY, 2014, J BONE MINER RES, V29, P2327, DOI 10.1002/jbmr.2288
   Clemens TL, 2011, J BONE MINER RES, V26, P677, DOI 10.1002/jbmr.321
   Confavreux CB, 2014, EUR J ENDOCRINOL, V171, P275, DOI 10.1530/EJE-13-0567
   Esposito K, 2013, J CLIN ENDOCR METAB, V98, P3306, DOI 10.1210/jc.2013-1775
   Evans AL, 2015, J BONE MINER RES, V30, P920, DOI 10.1002/jbmr.2407
   Farr JN, 2014, J BONE MINER RES, V29, P787, DOI 10.1002/jbmr.2106
   Hernández JL, 2010, MENOPAUSE, V17, P955, DOI 10.1097/gme.0b013e3181e39a15
   Ishii S, 2014, J BONE MINER RES, V29, P2561, DOI 10.1002/jbmr.2303
   Johansson H, 2014, J BONE MINER RES, V29, P223, DOI 10.1002/jbmr.2017
   Katz A, 2000, J CLIN ENDOCR METAB, V85, P2402, DOI 10.1210/jc.85.7.2402
   Kinjo M, 2007, J CLIN ENDOCR METAB, V92, P4161, DOI 10.1210/jc.2007-0757
   Lee DM, 2013, INT J EPIDEMIOL, V42, P391, DOI 10.1093/ije/dyr234
   Levy JC, 1998, DIABETES CARE, V21, P2191, DOI 10.2337/diacare.21.12.2191
   MILLER CG, 1993, OSTEOPOROSIS INT, V3, P31, DOI 10.1007/BF01623174
   Muka T, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0129116
   Parajuli A, 2015, BONE, V81, P152, DOI 10.1016/j.bone.2015.07.012
   Reaven GM, 2011, MED CLIN N AM, V95, P875, DOI 10.1016/j.mcna.2011.06.002
   ROSENQUIST C, 1995, CLIN CHEM, V41, P1439
   Schwartz AV, 2011, JAMA-J AM MED ASSOC, V305, P2184, DOI 10.1001/jama.2011.715
   Shen J, 2015, J BONE MINER RES, V30, P1301, DOI 10.1002/jbmr.2450
   Szulc P, 2010, J BONE MINER RES, V25, P1446, DOI 10.1002/jbmr.13
   Vanderschueren D, 2014, ENDOCR REV, V35, P906, DOI 10.1210/er.2014-1024
   Vanderschueren D, 2013, J CLIN ENDOCR METAB, V98, P995, DOI 10.1210/jc.2012-2772
   von Muhlen D, 2007, OSTEOPOROSIS INT, V18, P1337, DOI 10.1007/s00198-007-0385-1
   Ward KA, 2011, OSTEOPOROSIS INT, V22, P1513, DOI 10.1007/s00198-010-1437-5
   Yeap BB, 2015, J CLIN ENDOCR METAB, V100, P63, DOI 10.1210/jc.2014-3019
   Yu EW, 2015, OSTEOPOROSIS INT, V26, P673, DOI 10.1007/s00198-014-2927-7
   Yusuf E, 2012, ARTHRITIS RES THER, V14, DOI 10.1186/ar3894
NR 31
TC 28
Z9 31
U1 0
U2 4
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 0937-941X
EI 1433-2965
J9 OSTEOPOROSIS INT
JI Osteoporosis Int.
PD NOV
PY 2016
VL 27
IS 11
BP 3227
EP 3237
DI 10.1007/s00198-016-3656-x
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ED6GR
UT WOS:000388954600012
PM 27273111
DA 2025-06-11
ER

PT J
AU Liu, X
   Sun, XB
   Zhang, YK
   Jiang, WQ
   Lai, M
   Wiggins, KL
   Raffield, LM
   Bielak, LF
   Zhao, W
   Pitsillides, A
   Haessler, J
   Zheng, YA
   Blackwell, TW
   Yao, J
   Guo, XQ
   Qian, Y
   Thyagarajan, B
   Pankratz, N
   Rich, SS
   Taylor, KD
   Peyser, PA
   Heckbert, SR
   Seshadri, S
   Boerwinkle, E
   Grove, ML
   Larson, NB
   Smith, JA
   Vasan, RS
   Fitzpatrick, AL
   Fornage, M
   Ding, J
   Carson, AP
   Abecasis, G
   Dupuis, J
   Reiner, A
   Kooperberg, C
   Hou, LF
   Psaty, BM
   Wilson, JG
   Levy, D
   Rotter, JI
   Bis, JC
   Satizabal, CL
   Arking, DE
   Liu, CY
AF Liu, Xue
   Sun, Xianbang
   Zhang, Yuankai
   Jiang, Wenqing
   Lai, Meng
   Wiggins, Kerri L.
   Raffield, Laura M.
   Bielak, Lawrence F.
   Zhao, Wei
   Pitsillides, Achilleas
   Haessler, Jeffrey
   Zheng, Yinan
   Blackwell, Thomas W.
   Yao, Jie
   Guo, Xiuqing
   Qian, Yong
   Thyagarajan, Bharat
   Pankratz, Nathan
   Rich, Stephen S.
   Taylor, Kent D.
   Peyser, Patricia A.
   Heckbert, Susan R.
   Seshadri, Sudha
   Boerwinkle, Eric
   Grove, Megan L.
   Larson, Nicholas B.
   Smith, Jennifer A.
   Vasan, Ramachandran S.
   Fitzpatrick, Annette L.
   Fornage, Myriam
   Ding, Jun
   Carson, April P.
   Abecasis, Goncalo
   Dupuis, Josee
   Reiner, Alexander
   Kooperberg, Charles
   Hou, Lifang
   Psaty, Bruce M.
   Wilson, James G.
   Levy, Daniel
   Rotter, Jerome I.
   Bis, Joshua C.
   Satizabal, Claudia L.
   Arking, Dan E.
   Liu, Chunyu
CA TOPMeD mtDNA Working Grp NHLBI Tra
TI Association Between Whole Blood-Derived Mitochondrial DNA Copy Number,
   Low-Density Lipoprotein Cholesterol, and Cardiovascular Disease Risk
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE cardiometabolic risk factors; cardiovascular disease; low-density
   lipoprotein cholesterol; Mendelian randomization; mitochondrial DNA copy
   number; vascular atherosclerosis
ID MENDELIAN RANDOMIZATION; ATHEROSCLEROSIS RISK; OXIDATIVE STRESS;
   HEART-FAILURE; PERIPHERAL-BLOOD; DESIGN; HEALTH; COMMUNITIES;
   CLASSIFICATION; PLEIOTROPY
AB BACKGROUND: The relationship between mitochondrial DNA copy number (mtDNA CN) and cardiovascular disease remains elusive.
   METHODS AND RESULTS: We performed cross-sectional and prospective association analyses of blood-derived mtDNA CN and cardiovascular disease outcomes in 27 316 participants in 8 cohorts of multiple racial and ethnic groups with whole-genome sequencing. We also performed Mendelian randomization to explore causal relationships of mtDNA CN with coronary heart disease (CHD) and cardiometabolic risk factors (obesity, diabetes, hypertension, and hyperlipidemia). P<0.01 was used for significance. We validated most of the previously reported associations between mtDNA CN and cardiovascular disease outcomes. For example, 1-SD unit lower level of mtDNA CN was associated with 1.08 (95% CI, 1.04-1.12; P<0.001) times the hazard for developing incident CHD, adjusting for covariates. Mendelian randomization analyses showed no causal effect from a lower level of mtDNA CN to a higher CHD risk (beta=0.091; P=0.11) or in the reverse direction (beta=- 0.012; P=0.076). Additional bidirectional Mendelian randomization analyses revealed that low-density lipoprotein cholesterol had a causal effect on mtDNA CN (beta=-0.084; P<0.001), but the reverse direction was not significant (P=0.059). No causal associations were observed between mtDNA CN and obesity, diabetes, and hypertension, in either direction. Multivariable Mendelian randomization analyses showed no causal effect of CHD on mtDNA CN, controlling for low-density lipoprotein cholesterol level (P=0.52), whereas there was a strong direct causal effect of higher low-density lipoprotein cholesterol on lower mtDNA CN, adjusting for CHD status (beta=-0.092; P<0.001).
   CONCLUSIONS: Our findings indicate that high low-density lipoprotein cholesterol may underlie the complex relationships between mtDNA CN and vascular atherosclerosis.
C1 [Liu, Xue; Sun, Xianbang; Zhang, Yuankai; Jiang, Wenqing; Lai, Meng; Pitsillides, Achilleas; Dupuis, Josee; Liu, Chunyu] Boston Univ, Sch Publ Hlth, Dept Biostat, 801 Massachusetts Ave,Third Floor, Boston, MA 02118 USA.
   [Wiggins, Kerri L.; Psaty, Bruce M.; Bis, Joshua C.] Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.
   [Raffield, Laura M.] Univ N Carolina, Dept Genet, Chapel Hill, NC USA.
   [Bielak, Lawrence F.; Zhao, Wei; Peyser, Patricia A.; Smith, Jennifer A.] Univ Michigan, Dept Epidemiol, Sch Publ Hlth, Ann Arbor, MI USA.
   [Zhao, Wei; Smith, Jennifer A.] Univ Michigan, Survey Res Ctr, Inst Social Res, Ann Arbor, MI USA.
   [Haessler, Jeffrey; Reiner, Alexander; Kooperberg, Charles] Fred Hutchinson Canc Ctr, Div Publ Hlth Sci, Seattle, WA USA.
   [Zheng, Yinan; Hou, Lifang] Northwestern Univ, Feinberg Sch Med, Chicago, IL USA.
   [Blackwell, Thomas W.; Abecasis, Goncalo] Univ Michigan, TOPMed Informat Res Ctr, Ann Arbor, MI USA.
   [Yao, Jie; Guo, Xiuqing; Taylor, Kent D.; Rotter, Jerome I.] Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat, Torrance, CA USA.
   [Qian, Yong; Ding, Jun] NIA, Longitudinal Studies Sect, Translat Gerontol Branch, NIH, Baltimore, MD USA.
   [Thyagarajan, Bharat] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN USA.
   [Pankratz, Nathan] Univ Minnesota, Dept Computat Pathol, Minneapolis, MN USA.
   [Rich, Stephen S.] Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA.
   [Heckbert, Susan R.] Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA USA.
   [Heckbert, Susan R.] Univ Washington, Dept Epidemiol, Seattle, WA USA.
   [Seshadri, Sudha; Satizabal, Claudia L.] Univ Texas Hlth Sci Ctr San Antonio, Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX USA.
   [Seshadri, Sudha; Vasan, Ramachandran S.; Levy, Daniel; Satizabal, Claudia L.; Liu, Chunyu] NHLBI, Framingham Heart Study, Framingham, MA USA.
   [Seshadri, Sudha; Satizabal, Claudia L.] Boston Univ, Dept Neurol, Sch Med, Boston, MA USA.
   [Boerwinkle, Eric; Grove, Megan L.] Univ Texas Hlth Sci Ctr Houston, Ctr Human Genet, Dept Epidemiol Human Genet & Environm Sci, Houston, TX USA.
   [Boerwinkle, Eric] Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX USA.
   [Larson, Nicholas B.] Mayo Clin, Div Clin Trials & Biostat, Dept Quantitat Hlth Sci, Coll Med & Sci, Rochester, MN USA.
   [Vasan, Ramachandran S.] Boston Univ, Sch Med, Sect Prevent Med & Epidemiol, Boston, MA USA.
   [Vasan, Ramachandran S.] Boston Univ, Sch Med, Sect Cardiovasc Med, Boston, MA USA.
   [Fitzpatrick, Annette L.] Univ Washington, Dept Family Med, Seattle, WA USA.
   [Fitzpatrick, Annette L.; Psaty, Bruce M.] Univ Washington, Dept Epidemiol, Seattle, WA USA.
   [Fitzpatrick, Annette L.] Univ Washington, Dept Global Hlth, Seattle, WA USA.
   [Fornage, Myriam] Univ Texas Hlth Sci Ctr Houston, Ctr Human Genet, Houston, TX USA.
   [Carson, April P.] Univ Mississippi, Dept Med, Med Ctr, Jackson, MS USA.
   [Dupuis, Josee] McGill Univ, Fac Med & Hlth Sci, Dept Epidemiol Biostat & Occupat Hlth, Sch Populat & Global Hlth, Montreal, PQ, Canada.
   [Psaty, Bruce M.] Univ Washington, Dept Hlth Syst & Populat Hlth, Seattle, WA USA.
   [Wilson, James G.] Beth Israel Deaconess Med Ctr, Div Cardiovasc Med, Boston, MA USA.
   [Levy, Daniel] NHLBI, Populat Sci Branch, NIH, Bethesda, MD USA.
   [Arking, Dan E.] Johns Hopkins Univ, McKusick Nathans Inst, Dept Med Genet, Sch Med, Baltimore, MD USA.
C3 Boston University; University of Washington; University of Washington
   Seattle; University of North Carolina; University of North Carolina
   Chapel Hill; University of Michigan System; University of Michigan;
   University of Michigan System; University of Michigan; Fred Hutchinson
   Cancer Center; Northwestern University; Feinberg School of Medicine;
   University of Michigan System; University of Michigan; University of
   California System; University of California Los Angeles; University of
   California Los Angeles Medical Center; National Institutes of Health
   (NIH) - USA; NIH National Institute on Aging (NIA); University of
   Minnesota System; University of Minnesota Twin Cities; University of
   Minnesota System; University of Minnesota Twin Cities; University of
   Virginia; University of Washington; University of Washington Seattle;
   University of Washington; University of Washington Seattle; University
   of Texas System; University of Texas Health Science Center at San
   Antonio; National Institutes of Health (NIH) - USA; NIH National Heart
   Lung & Blood Institute (NHLBI); Framingham Heart Study; Boston
   University; University of Texas System; University of Texas Health
   Science Center Houston; Baylor College of Medicine; Mayo Clinic; Boston
   University; Boston University; University of Washington; University of
   Washington Seattle; University of Washington; University of Washington
   Seattle; University of Washington; University of Washington Seattle;
   University of Texas System; University of Texas Health Science Center
   Houston; University of Mississippi; University of Mississippi Medical
   Center; McGill University; University of Washington; University of
   Washington Seattle; Harvard University; Harvard University Medical
   Affiliates; Beth Israel Deaconess Medical Center; National Institutes of
   Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI);
   Johns Hopkins University
RP Liu, CY (corresponding author), Boston Univ, Sch Publ Hlth, Dept Biostat, 801 Massachusetts Ave,Third Floor, Boston, MA 02118 USA.
EM liuc@bu.edu
RI Larson, Nicholas/AEY-9578-2022; Zhang, Yuankai/GZK-8680-2022; Smith,
   Albert Vernon/AHC-3838-2022; Reiner-Benaim, Anat/HGQ-1183-2022;
   Ramachandran, Vasan/Y-2527-2019; Rotter, Jerome/AAY-6598-2021; jiang,
   wenqing/AAW-3649-2021; Liu, chunyu/Q-3901-2017; Boerwinkle,
   Eric/B-9599-2015; Zheng, Yinan/E-5775-2017; Levy, Daniel/ABB-2752-2021;
   Ford, James/A-4284-2013; Deng, Jun/X-6902-2019
OI Raffield, Laura/0000-0002-7892-193X; Wiggins, Kerri
   L/0000-0003-2749-1279; Hou, Lifang/0000-0003-4877-0031; Zhao,
   Wei/0000-0001-7388-0692; Smith, Jennifer Ann/0000-0002-3575-5468;
   Bielak, Lawrence/0000-0002-3443-8030; Pitsillides,
   Achilleas/0000-0002-2658-1566; Liu, Xue/0000-0002-4196-3597
FU National Heart, Lung, and Blood Institute (NHLBI); TOPMed Informatics
   Research Center [HHSN268201800002I]; TOPMed Data Coordinating Center
   [HHSN268201800002I, HHSN268201800001I]; NHLBI, National Institutes of
   Health, and Department of Health and Human Services [75N92022D00001,
   75N92022D00002, 75N92022D00003, 75N92022D00004, 75N92022D00005]; NHLBI;
   University of Alabama at Birmingham [HHSN268201800005I,
   HHSN268201800007I]; Northwestern University [HHSN268201800003I];
   University of Minnesota [HHSN268201800006I]; Kaiser Foundation Research
   Institute [HHSN268201800004I]; NHLBI [HHSN268201200036C,
   HHSN268200800007C, HHSN268201800001C, N01HC55222, N01HC85079,
   N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086,
   75N92021D00006, U01HL080295, U01HL130114, R01HL105756,
   HHSN268201600033I, 3U54HG003273-12S2, HHSN268201500015C, NO1-HC25195,
   HHSN268201500001I, 75N92019D00031, HHSN268201800013I, HHSN268201800014I,
   HHSN268201800015I, HHSN268201800010I, HHSN268201800011I,
   HHSN268201800012I]; National Institute on Aging (NIA) [R01AG023629];
   National Institute of Neurological Disorders and Stroke (NINDS); Evans
   Medical Foundation; Jay and Louis Coffman Endowment from the Department
   of Medicine, Boston University School of Medicine; NIA/NIH [AG052409,
   AG054076, AG059421]; NHLBI of the National Institutes of Health
   [HL054457, HL054464, HL054481, HL141292, HL119443, HL087660]; National
   Institute on Minority Health and Health Disparities (NIMHD); National
   Center for Advancing Translational Sciences, National Institutes of
   Health [KL2TR002490]; The NHLBI [75N92020D00001, HHSN268201500003I,
   N01-HC-95159, 75N92020D00005, N01-HC-95160, 75N92020D00002,
   N01-HC-95161, 75N92020D00003, N01-HC-95162, 75N92020D00006,
   N01-HC-95163, 75N92020D00004, N01-HC-95164, 75N92020D00007,
   N01-HC-95165]; NHLBI, National Institutes of Health, US Department of
   Health and Human Services [75N92021D00001, 75N92021D00002,
   75N92021D00003, 75N92021D00004, 75N92021D00005]; 'NHLBI' [R01HL105756,
   N01-HC-95166, N01-HC-95167, N01-HC95168, N01-HC-95169, UL1-TR-000040,
   UL1-TR-001079, UL1-TR001420, UL1TR001881, DK063491];  [R01
   HL092577-06S1];  [R01AG059727]
FX Whole-genome sequencing (WGS) for the Trans-Omics in Precision Medicine
   (TOPMed) program was supported by the National Heart, Lung, and Blood
   Institute (NHLBI). Centralized read mapping and genotype calling, along
   with variant quality metrics and filtering, were provided by the TOPMed
   Informatics Research Center (R01HL-117 626-02S1; contract
   HHSN268201800002I). Phenotype harmonization, data management,
   sample-identity quality control, and general study coordination were
   provided by the TOPMed Data Coordinating Center (R01HL-120 393-02S1;
   contract HHSN268201800001I). Additional phenotype harmonization was
   performed by the current study (NIA/NIH; R01AG059727). Funding resources
   for all participating institutes are described below. The ARIC
   (Atherosclerosis Risk in Communities) study has been funded in whole or
   in part with federal funds from the NHLBI, National Institutes of
   Health, and Department of Health and Human Services, under contracts
   75N92022D00001, 75N92022D00002, 75N92022D00003, 75N92022D00004, and
   75N92022D00005. The authors thank the staff and participants of the ARIC
   study for their important contributions. WGS for "NHLBI TOPMed:
   Atherosclerosis Risk in Communities" (phs001211.v3.p2.c1) was performed
   at the Baylor College of Medicine Human Genome Sequencing Center
   (3U54HG003273-12S2/HHSN268201500015C). Core support, including
   centralized genomic read mapping and genotype calling, along with
   variant quality metrics and filtering were provided by the TOPMed
   Informatics Research Center (3R01HL-117 626-02S1; contract
   HHSN268201800002I). Core support, including phenotype harmonization,
   data management, sample-identity quality control, and general program
   coordination were provided by the TOPMed Data Coordinating Center
   (R01HL-120393; U01HL-120393; contract HHSN268201800001I). The ARIC study
   gratefully acknowledges the study participants who provided biological
   samples and data for TOPMed. The CARDIA (Coronary Artery Risk
   Development in Young Adults) study is conducted and supported by the
   NHLBI in collaboration with the University of Alabama at Birmingham
   (HHSN268201800005I and HHSN268201800007I), Northwestern University
   (HHSN268201800003I), University of Minnesota (HHSN268201800006I), and
   Kaiser Foundation Research Institute (HHSN268201800004I). WGS in CARDIA
   (phs001612) was performed at the Baylor Human Genome Sequencing Center
   (HHSN268201600033I). Centralized read mapping and genotype calling,
   along with variant quality metrics and filtering, were provided by the
   TOPMed Informatics Research Center (3R01HL-117 626-02S1). Phenotype
   harmonization, data management, sample-identity quality control, and
   general study coordination were provided by the TOPMed Data Coordinating
   Center (3R01HL-120 393-02S1). The CARDIA study gratefully acknowledges
   the study participants who provided biological samples and data for
   TOPMed. We also thank the staff of the CARDIA study. The CHS
   (Cardiovascular Health Study) is supported by contracts
   HHSN268201200036C, HHSN268200800007C, HHSN268201800001C, N01HC55222,
   N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086,
   and 75N92021D00006 and grants U01HL080295, U01HL130114, and R01HL105756
   from the NHLBI, with additional contribution from the National Institute
   of Neurological Disorders and Stroke (NINDS). Additional support was
   provided by R01AG023629 from the National Institute on Aging (NIA). A
   full list of principal CHS investigators and institutions can be found
   at CHS-NHLBI. org. The content is solely the responsibility of the
   authors and does not necessarily represent the official views of the
   National Institutes of Health. Sequencing was supported and conducted in
   collaboration with Baylor University (HHSN268201600033I,
   3U54HG003273-12S2, and HHSN268201500015C) and Broad Genomics
   (HHSN268201600034I) contracts from NHLBI. The WGS for FHS (Framingham
   Heart Study) (phs000974) was performed at the Broad Institute of MIT and
   Harvard (3R01HL092577-06S1 and 3U54HG003067-12S2). The FHS is funded by
   contracts NO1-HC25195, HHSN268201500001I, and 75N92019D00031 from the
   NHLBI and grant supplement R01 HL092577-06S1 for this research. The FHS
   also acknowledges the dedication of the FHS participants without whom
   this research would not be possible. Dr Vasan is supported in part by
   the Evans Medical Foundation and the Jay and Louis Coffman Endowment
   from the Department of Medicine, Boston University School of Medicine.
   Xue Liu, Sudha Seshadri, Claudia L. Satizabal, and Chunyu Liu are also
   supported by R01AG059727. Sudha Seshadri, Claudia L. Satizabal are also
   supported by NIA/NIH (AG052409, AG054076, and AG059421). The GENOA
   (Genetic Epidemiology Network of Arteriopathy) study is supported by the
   NHLBI (HL054457, HL054464, HL054481, HL141292, HL119443, and HL087660)
   of the National Institutes of Health. Sequencing for the GENOA
   (phs001345. v1.p1) was performed by the University of Washington
   Northwest Genomics Center (3R01HL055673-18S1 from the NHLBI and at the
   Broad Institute of MIT and Harvard [HHSN268201500014C]). The authors
   thank the staff and participants of GENOA. The JHS (Jackson Heart Study)
   is supported and conducted in collaboration with Jackson State
   University (HHSN268201800013I), Tougaloo College (HHSN268201800014I),
   the Mississippi State Department of Health (HHSN268201800015I), and the
   University of Mississippi Medical Center (HHSN268201800010I,
   HHSN268201800011I, and HHSN268201800012I) contracts from the NHLBI and
   the National Institute on Minority Health and Health Disparities
   (NIMHD). The authors thank the staff and participants of the JHS.
   Molecular data for the TOPMed program were supported by the NHLBI.
   Genome sequencing for "NHLBI TOPMed: The Jackson Heart Study"
   (phs000964.v1.p1) was performed at the Northwest Genomics Center
   (HHSN268201100037C). Core support, including centralized genomic read
   mapping and genotype calling, along with variant quality metrics and
   filtering, was provided by the TOPMed Informatics Research Center
   (3R01HL-117 626-02S1; contract HHSN268201800002I). Core support,
   including phenotype harmonization, data management, sample-identity
   quality control, and general program coordination, was provided by the
   TOPMed Data Coordinating Center (R01HL-120 393 and U01HL-120 393;
   contract HHSN268201800001I). Laura Raffield was also supported by the
   National Center for Advancing Translational Sciences, National
   Institutes of Health, through grant KL2TR002490. The JHS gratefully
   acknowledges the studies and participants who provided biological
   samples and data for TOPMed. The MESA (Multi-Ethnic Study of
   Atherosclerosis) is conducted and supported by the NHLBI in
   collaboration with MESA investigators. MESA projects are conducted and
   supported by the NHLBI in collaboration with MESA investigators. Support
   for MESA is provided by contracts 75N92020D00001, HHSN268201500003I,
   N01-HC-95159, 75N92020D00005, N01-HC-95160, 75N92020D00002,
   N01-HC-95161, 75N92020D00003, N01-HC-95162, 75N92020D00006,
   N01-HC-95163, 75N92020D00004, N01-HC-95164, 75N92020D00007,
   N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC95168, N01-HC-95169,
   UL1-TR-000040, UL1-TR-001079, UL1-TR001420, UL1TR001881, DK063491, and
   R01HL105756. WGS for the TOPMed program was supported by the NHLBI. WGS
   for "NHLBI TOPMed: Multi-Ethnic Study of Atherosclerosis (MESA)"
   (phs001416.v1.p1) was performed at the Broad Institute of MIT and
   Harvard (3U54HG003067-13S1). Centralized read mapping and genotype
   calling, along with variant quality metrics and filtering, were provided
   by the TOPMed Informatics Research Center (3R01HL-117 626-02S1).
   Phenotype harmonization, data management, sample-identity quality
   control, and general study coordination, were provided by the TOPMed
   Data Coordinating Center (3R01HL-120 393-02S1) and TOPMed MESA
   Multi-Omics (HHSN2682015000031/HSN26800004). The authors thank the other
   investigators, the staff, and the participants of the MESA for their
   valuable contributions. A full list of participating MESA investigators
   and institutes can be found at http://www.mesa-nhlbi.org.The WHI
   (Women's Health Initiative) study program is funded by the NHLBI,
   National Institutes of Health, US Department of Health and Human
   Services through contracts 75N92021D00001, 75N92021D00002,
   75N92021D00003, 75N92021D00004, and 75N92021D00005. The WHI study thanks
   all WHI study participants for their dedication and contributions. The
   views expressed in this article are those of the authors and do not
   necessarily represent the views of the NHLBI, the National Institutes of
   Health, or the US Department of Health and Human Services.
CR ADAMS HP, 1993, STROKE, V24, P35, DOI 10.1161/01.STR.24.1.35
   Alberts B., 2002, Molecular Biology of the Cell, V4
   Alfaddagh A, 2020, AM J PREVENT CARDIOL, V4, DOI 10.1016/j.ajpc.2020.100130
   Anderson GL, 2003, ANN EPIDEMIOL, V13, pS5, DOI 10.1016/S1047-2797(03)00043-7
   Ashar FN, 2017, JAMA CARDIOL, V2, P1247, DOI 10.1001/jamacardio.2017.3683
   Ashar FN, 2015, J MOL MED, V93, P177, DOI 10.1007/s00109-014-1233-3
   Baigent C, 2005, LANCET, V366, P1267, DOI 10.1016/S0140-6736(05)67394-1
   Ballinger SW, 2002, CIRCULATION, V106, P544, DOI 10.1161/01.CIR.0000023921.93743.89
   Barbalic M, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002199
   Bennet AM, 2010, J ALZHEIMERS DIS, V22, P129, DOI 10.3233/JAD-2010-100864
   Bild DE, 2002, AM J EPIDEMIOL, V156, P871, DOI 10.1093/aje/kwf113
   Bowden J, 2016, GENET EPIDEMIOL, V40, P304, DOI 10.1002/gepi.21965
   Bowden J, 2015, INT J EPIDEMIOL, V44, P512, DOI 10.1093/ije/dyv080
   Burgess S, 2016, Genet Epidemiol, V40, P597
   Burgess S, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-019-14156-4
   Burgess S, 2017, GENETICS, V207, P481, DOI 10.1534/genetics.117.300191
   Burgess S, 2017, EUR J EPIDEMIOL, V32, P377, DOI 10.1007/s10654-017-0255-x
   Burgess S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0108891
   Castellani CA, 2020, MITOCHONDRION, V53, P214, DOI 10.1016/j.mito.2020.06.004
   Daniels PR, 2004, AM J MED, V116, P676, DOI 10.1016/j.amjmed.2003.12.032
   Davey Smith G, 2014, HUM MOL GENET, V23, pR89, DOI 10.1093/hmg/ddu328
   Davies NM, 2018, BMJ-BRIT MED J, V362, DOI 10.1136/bmj.k601
   Dawber TR, 1951, AM J PUBLIC HEALTH N, V41, P279, DOI 10.2105/ajph.41.3.279
   Ding J, 2015, PLOS GENET, V11, DOI [10.1371/journal.pgen.1005306, 10.1371/journal.pgen.1005549]
   Doenst T, 2013, CIRC RES, V113, P709, DOI 10.1161/CIRCRESAHA.113.300376
   Elsworth BL, 2020, bioRxiv, DOI [10.1101/2020.08.10.244293, 10.1101/2020.08.10.244293, DOI 10.1101/2020.08.10.244293]
   Fazzini F, 2019, KIDNEY INT, V96, P480, DOI 10.1016/j.kint.2019.04.021
   FEINLEIB M, 1975, PREV MED, V4, P518, DOI 10.1016/0091-7435(75)90037-7
   Fried Linda P., 1991, Annals of Epidemiology, V1, P263
   FRIEDMAN GD, 1990, INT J EPIDEMIOL, V19, P889, DOI 10.1093/ije/19.4.889
   Graham SE, 2021, NATURE, V600, P675, DOI 10.1038/s41586-021-04064-3
   Hartwig FP, 2017, INT J EPIDEMIOL, V46, P1985, DOI 10.1093/ije/dyx102
   Hemani G, 2018, ELIFE, V7, DOI 10.7554/eLife.34408
   Kanoni S, 2022, GENOME BIOL, V23, DOI 10.1186/s13059-022-02837-1
   Kobiyama K, 2018, CIRC RES, V123, P1118, DOI 10.1161/CIRCRESAHA.118.313816
   Kujoth GC, 2005, SCIENCE, V309, P481, DOI 10.1126/science.1112125
   Lee CF, 2005, ANN NY ACAD SCI, V1042, P246, DOI 10.1196/annals.1338.027
   Lee YT, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-016-0402-5
   Liu X, 2021, CELL GENOM, V1, DOI 10.1016/j.xgen.2021.100006
   Longchamps RJ, 2022, HUM GENET, V141, P127, DOI 10.1007/s00439-021-02394-w
   Mahajan A, 2022, NAT GENET, V54, P560, DOI 10.1038/s41588-022-01058-3
   Malik AN, 2013, MITOCHONDRION, V13, P481, DOI 10.1016/j.mito.2012.10.011
   Mc Namara K, 2019, INTEGR PHARM RES PRA, V8, P1, DOI 10.2147/IPRP.S133088
   Mengel-From J, 2014, HUM GENET, V133, P1149, DOI 10.1007/s00439-014-1458-9
   Mi HY, 2019, NAT PROTOC, V14, P703, DOI 10.1038/s41596-019-0128-8
   Minelli C, 2021, INT J EPIDEMIOL, V50, P1651, DOI 10.1093/ije/dyab084
   Mudd JO, 2008, NATURE, V451, P919, DOI 10.1038/nature06798
   Picard M, 2021, MITOCHONDRION, V60, P1, DOI 10.1016/j.mito.2021.06.010
   Psaty BM, 2016, CIRCULATION, V133, P156, DOI 10.1161/CIRCULATIONAHA.115.018610
   Ramdas S, 2022, AM J HUM GENET, V109, P1366, DOI 10.1016/j.ajhg.2022.06.012
   Relton CL, 2012, INT J EPIDEMIOL, V41, P161, DOI 10.1093/ije/dyr233
   Reznik E, 2016, ELIFE, V5, DOI 10.7554/eLife.10769
   Rosa HS, 2020, FASEB J, V34, P12278, DOI 10.1096/fj.202000959RR
   Rosamond WD, 2012, CIRC-HEART FAIL, V5, P152, DOI 10.1161/CIRCHEARTFAILURE.111.963199
   Sanderson E, 2019, Int J Epidemiol, V48, P713
   Splansky GL, 2007, AM J EPIDEMIOL, V165, P1328, DOI 10.1093/aje/kwm021
   Taliun D, 2021, NATURE, V590, DOI 10.1038/s41586-021-03205-y
   Taylor RW, 2005, NAT REV GENET, V6, P389, DOI 10.1038/nrg1606
   Tin A, 2016, J AM SOC NEPHROL, V27, P2467, DOI 10.1681/ASN.2015060661
   Trifunovic A, 2004, NATURE, V429, P417, DOI 10.1038/nature02517
   Tsao CW, 2015, INT J EPIDEMIOL, V44, P1800, DOI 10.1093/ije/dyv337
   van der Harst P, 2018, CIRC RES, V122, P433, DOI [10.1161/CIRCRESAHA.117.312086, 10.1161/circresaha.117.312086]
   Verbanck M, 2018, NAT GENET, V50, P693, DOI 10.1038/s41588-018-0099-7
   Walker Venexia M, 2019, Wellcome Open Res, V4, P113, DOI 10.12688/wellcomeopenres.15334.1
   Willerson JT, 2004, CIRCULATION, V109, P2, DOI 10.1161/01.CIR.0000129535.04194.38
   WILLIAMS OD, 1989, AM J EPIDEMIOL, V129, P687, DOI 10.1093/oxfordjournals.aje.a115184
   Wilson JG, 2005, ETHNIC DIS, V15, pS30
   Wu SN, 2011, FEBS J, V278, P941, DOI 10.1111/j.1742-4658.2011.08010.x
   Yang SY, 2021, GENOME RES, V31, P349, DOI 10.1101/gr.269381.120
   Zhang YY, 2017, EUR HEART J, V38, P3443, DOI 10.1093/eurheartj/ehx354
   Zorov DB, 2000, J EXP MED, V192, P1001, DOI 10.1084/jem.192.7.1001
   Zorov DB, 2014, PHYSIOL REV, V94, P909, DOI 10.1152/physrev.00026.2013
NR 72
TC 10
Z9 10
U1 1
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD OCT 17
PY 2023
VL 12
IS 20
AR e029090
DI 10.1161/JAHA.122.029090
PG 13
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA W1ZG5
UT WOS:001089678400035
PM 37804200
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU McIntyre, RS
   Cha, DS
   Jerrell, JM
   Soczynska, JK
   Woldeyohannes, HO
   Taylor, V
   Kaidanovich-Beilin, O
   Alsuwaidan, M
   Ahmed, AT
AF McIntyre, Roger S.
   Cha, Danielle S.
   Jerrell, Jeanette M.
   Soczynska, Joanna K.
   Woldeyohannes, Hanna O.
   Taylor, Valerie
   Kaidanovich-Beilin, Oksana
   Alsuwaidan, Mohammad
   Ahmed, Ameena T.
TI Obesity and Mental Illness: Implications for Cognitive Functioning
SO ADVANCES IN THERAPY
LA English
DT Review
DE Cognition; Dementia; Mental illness; Mood disorder; Neuropsychiatric
   disorders; Obesity; Psychiatry
ID ANXIETY TREATMENTS CANMAT; TASK-FORCE RECOMMENDATIONS; BODY-MASS INDEX;
   BIPOLAR DISORDER; DEFAULT-MODE; CANADIAN NETWORK; MOOD DISORDERS;
   METABOLIC SYNDROME; ALZHEIMERS-DISEASE; PREFRONTAL CORTEX
AB A priority research and clinical agenda is to identify determinants of cognitive impairment in individuals with neuropsychiatric disorders (NPD). The bidirectional association between NPD and cognitive performance has been reported to be mediated and/or moderated by obesity in a subset of individuals. Obesity can be conceptualized as a neurotoxic phenotype among individuals with NPD as evidenced by alterations in the structure and function of neural circuits and disseminated networks, diminished cognitive performance, and adverse effects on illness trajectory. The neurotoxic effect of obesity provides a rationale for screening, treating, and preventing obesity in neuropsychiatric populations. Research endeavors that aim to refine mediators and moderators of this association as well as novel strategies to reverse the injurious process of obesity on cognition are warranted.
C1 [McIntyre, Roger S.; Alsuwaidan, Mohammad] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [McIntyre, Roger S.] Univ Toronto, Dept Pharmacol, Toronto, ON, Canada.
   [McIntyre, Roger S.; Cha, Danielle S.; Soczynska, Joanna K.] Univ Toronto, Inst Med Sci, Toronto, ON, Canada.
   [McIntyre, Roger S.; Cha, Danielle S.; Soczynska, Joanna K.; Woldeyohannes, Hanna O.; Kaidanovich-Beilin, Oksana; Alsuwaidan, Mohammad] Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON M5T 2S8, Canada.
   [Jerrell, Jeanette M.] Univ S Carolina, Sch Med, Dept Neuropsychiat, Columbia, SC USA.
   [Taylor, Valerie] Univ Toronto, Toronto, ON, Canada.
   [Kaidanovich-Beilin, Oksana] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada.
   [Ahmed, Ameena T.] Permanente Med Grp Inc, San Francisco, CA 94115 USA.
   [Ahmed, Ameena T.] Kaiser Permanente Div Res, San Francisco, CA 94115 USA.
C3 University of Toronto; University of Toronto; University of Toronto;
   University of Toronto; University Health Network Toronto; University of
   South Carolina System; University of South Carolina Columbia; University
   of Toronto; University of Toronto; Sinai Health System Toronto;
   Lunenfeld Tanenbaum Research Institute; Permanente Medical Groups;
   Kaiser Permanente
RP McIntyre, RS (corresponding author), Univ Hlth Network, Mood Disorders Psychopharmacol Unit, 399 Bathurst St, Toronto, ON M5T 2S8, Canada.
EM Roger.McIntyre@uhn.ca
RI McIntyre, Roger/AAU-1000-2020; Taylor, Valerie/H-6242-2015
OI Taylor, Valerie/0000-0002-8948-638X; Alsuwaidan,
   Mohammad/0000-0003-1344-2935; Soczynska, Joanna/0000-0003-0003-7164
FU Stanley Medical Research Institute; National Alliance for Research on
   Schizophrenia and Depression (NARSAD); National Institutes of Mental
   Health; Astra Zeneca; Eli Lilly; Jannsen-Ortho; Lundbeck; Pfizer; Shire;
   Elan; Sunovion; CANMAT; Servier
FX RS McIntyre has received research grants from Stanley Medical Research
   Institute, National Alliance for Research on Schizophrenia and
   Depression (NARSAD), National Institutes of Mental Health, Astra Zeneca,
   Eli Lilly, Jannsen-Ortho, Lundbeck, Pfizer, and Shire; has served on
   advisory boards for Astra Zeneca, Bristol-Myers Squibb, Eli Lilly,
   France Foundation, GlaxoSmithKline, Janssen-Ortho, Lundbeck, Merck,
   Organon, Pfizer, and Shire; has served on speakers bureaus for Astra
   Zeneca, Eli Lilly, Janssen-Ortho, Lundbeck, Merck, Pfizer; and CME
   activities for Astra Zeneca, Bristol-Myers Squibb, CME Outfitters, Eli
   Lilly, France Foundation, I3CME, Merck, Optum Health, Pfizer,
   Physicians' Postgraduate Press. M. Alsuwaidan has received
   research/clinical trials grants from Elan, Lundbeck, Shire, and
   Sunovion; honoraria from Astra Zeneca and CANMAT; and travel funds from
   CANMAT and Servier. D. Cha declares no conflict of interest. J. Jerrell
   declares no conflict of interest. J. Soczynska declares no conflict of
   interest. H. Woldeyohannes declares no conflict of interest. V. Taylor
   declares no conflict of interest. O. Kaidanovich-Beilin declares no
   conflict of interest. A. Ahmed declares no conflict of interest.
CR Alonso J, 2011, PSYCHOL MED, V41, P873, DOI 10.1017/S0033291710001212
   Andreazza AC, 2008, J AFFECT DISORDERS, V111, P135, DOI 10.1016/j.jad.2008.04.013
   Andreazza AC, 2009, J PSYCHIATR NEUROSCI, V34
   [Anonymous], CAN J PSYCHIAT S1
   Bagger YZ, 2004, OBES RES, V12, P1519, DOI 10.1038/oby.2004.189
   Baydas G, 2003, LIFE SCI, V73, P1907, DOI 10.1016/S0024-3205(03)00561-7
   Berk M, 2011, NEUROSCI BIOBEHAV R, V35, P804, DOI 10.1016/j.neubiorev.2010.10.001
   Bob P, 2010, J AFFECT DISORDERS, V120, P231, DOI 10.1016/j.jad.2009.03.017
   Bond DJ, 2012, ANN CLIN PSYCHIATRY, V24, P23
   Bray GA, 2003, ENDOCRIN METAB CLIN, V32, P787, DOI 10.1016/S0889-8529(03)00067-7
   Broyd SJ, 2009, NEUROSCI BIOBEHAV R, V33, P279, DOI 10.1016/j.neubiorev.2008.09.002
   Buckner RL, 2005, J NEUROSCI, V25, P7709, DOI 10.1523/JNEUROSCI.2177-05.2005
   Chang CK, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019590
   Chico L, 2013, FREE RADICAL RES, V47, P569, DOI 10.3109/10715762.2013.804622
   Collins PY, 2011, NATURE, V475, P27, DOI 10.1038/475027a
   Cournot M, 2006, NEUROLOGY, V67, P1208, DOI 10.1212/01.wnl.0000238082.13860.50
   Craft S, 2004, LANCET NEUROL, V3, P169, DOI 10.1016/S1474-4422(04)00681-7
   Cserjési R, 2009, APPETITE, V52, P535, DOI 10.1016/j.appet.2009.01.003
   Dean B, 2011, INT J NEUROPSYCHOPH, V14, P997, DOI 10.1017/S1461145710001410
   Delgado-Rico E, 2012, OBESITY, V20, P1604, DOI 10.1038/oby.2012.47
   Dhabhar FS, 2009, J PSYCHIATR RES, V43, P962, DOI 10.1016/j.jpsychires.2009.05.010
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Drexhage RC, 2010, EXPERT REV NEUROTHER, V10, P59, DOI 10.1586/ERN.09.144
   Elias MF, 2003, INT J OBESITY, V27, P260, DOI 10.1038/sj.ijo.802225
   Galioto R, 2012, COMPR PSYCHIAT, V53, P490, DOI 10.1016/j.comppsych.2011.09.002
   García-García I, 2013, NEUROIMAGE, V66, P232, DOI 10.1016/j.neuroimage.2012.10.035
   Garcia-Portilla MP, 2008, J AFFECT DISORDERS, V106, P197, DOI 10.1016/j.jad.2007.06.002
   Gilbert SJ, 2006, J COGNITIVE NEUROSCI, V18, P932, DOI 10.1162/jocn.2006.18.6.932
   Gispen WH, 2000, TRENDS NEUROSCI, V23, P542, DOI 10.1016/S0166-2236(00)01656-8
   Greenwood CE, 2001, NEUROBIOL LEARN MEM, V75, P179, DOI 10.1006/nlme.2000.3964
   Greicius MD, 2003, P NATL ACAD SCI USA, V100, P253, DOI 10.1073/pnas.0135058100
   Grosshans M, 2011, ADDICT BIOL, V16, P189, DOI 10.1111/j.1369-1600.2010.00300.x
   Gurpegui M, 2012, PROG NEURO-PSYCHOPH, V37, P169, DOI 10.1016/j.pnpbp.2012.01.014
   Gusnard DA, 2001, P NATL ACAD SCI USA, V98, P4259, DOI 10.1073/pnas.071043098
   Gustafson D, 2003, ARCH INTERN MED, V163, P1524, DOI 10.1001/archinte.163.13.1524
   Gustafson DR, 2012, J ALZHEIMERS DIS, V30, pS97, DOI 10.3233/JAD-2012-120487
   Harrison NA, 2009, BIOL PSYCHIAT, V66, P407, DOI 10.1016/j.biopsych.2009.03.015
   Henderson DC, 2008, J CLIN PSYCHIAT, V69, P32, DOI 10.4088/JCP.0208e04
   Hendrickx H, 2005, NEUROBIOL AGING, V26, pS1, DOI 10.1016/j.neurobiolaging.2005.10.005
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Jones A, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039143
   Joseph RJ, 2011, OBES REV, V12, P800, DOI 10.1111/j.1467-789X.2011.00893.x
   Kanaya AM, 2009, ARCH NEUROL-CHICAGO, V66, P329, DOI 10.1001/archneurol.2008.570
   Kenna HA, 2009, HARVARD REV PSYCHIAT, V17, P138, DOI 10.1080/10673220902899722
   Kerwin DR, 2011, J AM GERIATR SOC, V59, P107, DOI 10.1111/j.1532-5415.2010.03219.x
   Kessler RC, 2012, INT J METH PSYCH RES, V21, P169, DOI 10.1002/mpr.1359
   Khanzode SD, 2003, REDOX REP, V8, P365, DOI 10.1179/135100003225003393
   Kim B, 2008, J AFFECT DISORDERS, V105, P45, DOI 10.1016/j.jad.2007.04.006
   Kivipelto M, 2005, ARCH NEUROL-CHICAGO, V62, P1556, DOI 10.1001/archneur.62.10.1556
   Kullmann S, 2012, HUM BRAIN MAPP, V33, P1052, DOI 10.1002/hbm.21268
   Laitala VS, 2011, CURR ALZHEIMER RES, V8, P699
   Magariños AM, 2000, P NATL ACAD SCI USA, V97, P11056, DOI 10.1073/pnas.97.20.11056
   MASTERS BA, 1987, BRAIN RES, V417, P247, DOI 10.1016/0006-8993(87)90449-5
   McElroy S.L., 2006, OBESITY MENTAL DISOR
   McEwen BS, 2002, J PSYCHOSOM RES, V53, P883, DOI 10.1016/S0022-3999(02)00307-0
   McEwen BS, 1997, NEUROLOGY, V48, pS8, DOI 10.1212/WNL.48.5_Suppl_7.8S
   McEwen BS, 1999, ANNU REV NEUROSCI, V22, P105, DOI 10.1146/annurev.neuro.22.1.105
   McIntyre Roger S, 2007, Ann Clin Psychiatry, V19, P257, DOI 10.1080/10401230701653377
   McIntyre RS, 2012, ANN CLIN PSYCHIATRY, V24, P69
   McIntyre Roger S, 2009, J Clin Psychiatry, V70, pe23
   McIntyre RS, 2003, BIPOLAR DISORD, V5, P28, DOI 10.1034/j.1399-5618.2003.00009.x
   Megna JL, 2011, ANN CLIN PSYCHIATRY, V23, P131
   Mire-Sluis A R, 1999, Dev Biol Stand, V97, P171
   Morrato EH, 2010, ARCH GEN PSYCHIAT, V67, P17, DOI 10.1001/archgenpsychiatry.2009.179
   Musen G, 2012, DIABETES, V61, P2375, DOI 10.2337/db11-1669
   Musselman DL, 2003, BIOL PSYCHIAT, V54, P317, DOI 10.1016/S0006-3223(03)00569-9
   Naderali EK, 2009, AM J ALZHEIMERS DIS, V24, P445, DOI 10.1177/1533317509348208
   Ozcan ME, 2004, INT CLIN PSYCHOPHARM, V19, P89, DOI 10.1097/01.yic.0000110796.97676.89
   Raichle ME, 2001, P NATL ACAD SCI USA, V98, P676, DOI 10.1073/pnas.98.2.676
   Ramacciotti CE, 2008, INT J EAT DISORDER, V41, P643, DOI 10.1002/eat.20544
   Ravaldi C, 2005, J CLIN PSYCHIAT, V66, P265, DOI 10.4088/JCP.v66n0217a
   Reagan LP, 2001, P NATL ACAD SCI USA, V98, P2820, DOI 10.1073/pnas.051629798
   Reichenberg A, 2001, ARCH GEN PSYCHIAT, V58, P445, DOI 10.1001/archpsyc.58.5.445
   Reus VI, 2001, EXPERT OPIN INV DRUG, V10, P1789, DOI 10.1517/13543784.10.10.1789
   RICHARDSON JTE, 1990, NEUROSCI BIOBEHAV R, V14, P385, DOI 10.1016/S0149-7634(05)80060-0
   Rössler W, 2012, EUR ARCH PSY CLIN N, V262, pS65, DOI 10.1007/s00406-012-0353-4
   Rush AJ, 1996, J CLIN PSYCHIAT, V57, P470, DOI 10.4088/JCP.v57n1006
   Selek S, 2008, J AFFECT DISORDERS, V107, P89, DOI 10.1016/j.jad.2007.08.006
   SHAPIRO E, 1991, J NEUROBIOL, V22, P55, DOI 10.1002/neu.480220106
   SHIBATA S, 1986, PHYSIOL BEHAV, V36, P79, DOI 10.1016/0031-9384(86)90077-6
   Singh-Manoux A, 2012, NEUROLOGY, V79, P755, DOI 10.1212/WNL.0b013e3182661f63
   Soczynska JK, 2011, NEUROMOL MED, V13, P93, DOI 10.1007/s12017-010-8140-8
   Stanley SH, 2012, AUST J PRIM HEALTH, V18, P258, DOI 10.1071/PY11045
   Taylor VH, 2012, CAN J PSYCHIAT, V57, P5, DOI 10.1177/070674371205700103
   Uddin LQ, 2009, HUM BRAIN MAPP, V30, P625, DOI 10.1002/hbm.20531
   Vieta E, 2013, EUR PSYCHIAT, V28, P21, DOI 10.1016/j.eurpsy.2011.11.007
   Volkow ND, 2011, MOL PSYCHIATR, V16, P818, DOI 10.1038/mp.2011.30
   Whitfield-Gabrieli S, 2012, ANNU REV CLIN PSYCHO, V8, P49, DOI 10.1146/annurev-clinpsy-032511-143049
   Whitmer RA, 2008, NEUROLOGY, V71, P1057, DOI 10.1212/01.wnl.0000306313.89165.ef
   Whitmer RA, 2005, BMJ-BRIT MED J, V330, P1360, DOI 10.1136/bmj.38446.466238.E0
   Williams JMG, 2002, PSYCHOL MED, V32, P469, DOI 10.1017/S0033291701005177
   Wilson PWF, 2003, CIRCULATION, V108, P1422, DOI 10.1161/01.CIR.0000089505.34741.E5
   Yatham LN, 2009, BIPOLAR DISORD, V11, P225, DOI 10.1111/j.1399-5618.2009.00672.x
   Yatham LN, 2005, BIPOLAR DISORD, V7, P5, DOI 10.1111/j.1399-5618.2005.00219.x
   Yau PL, 2012, PEDIATRICS, V130, pE856, DOI 10.1542/peds.2012-0324
   Yim CY, 2012, EUR PSYCHIAT, V27, P223, DOI 10.1016/j.eurpsy.2011.02.004
   Yoon DH, 2012, AGE AGEING, V41, P456, DOI 10.1093/ageing/afs018
   Zhu XL, 2012, BIOL PSYCHIAT, V71, P611, DOI 10.1016/j.biopsych.2011.10.035
   Zorrilla EP, 2001, BRAIN BEHAV IMMUN, V15, P199, DOI 10.1006/brbi.2000.0597
NR 99
TC 13
Z9 14
U1 2
U2 23
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0741-238X
EI 1865-8652
J9 ADV THER
JI Adv. Ther.
PD JUN
PY 2013
VL 30
IS 6
BP 577
EP 588
DI 10.1007/s12325-013-0040-5
PG 12
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 180HY
UT WOS:000321586000002
PM 23839214
DA 2025-06-11
ER

PT J
AU de la Iglesia, R
   Lopez-Legarrea, P
   Abete, I
   Bondia-Pons, I
   Navas-Carretero, S
   Forga, L
   Martinez, JA
   Zulet, MA
AF de la Iglesia, Rocio
   Lopez-Legarrea, Patricia
   Abete, Itziar
   Bondia-Pons, Isabel
   Navas-Carretero, Santiago
   Forga, Luis
   Alfredo Martinez, J.
   Angeles Zulet, M.
TI A new dietary strategy for long-term treatment of the metabolic syndrome
   is compared with the American Heart Association ( AHA) guidelines: the
   MEtabolic Syndrome REduction in NAvarra ( RESMENA) project
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Obesity; Energy restriction; Fibre; Macronutrient distribution
ID SERUM URIC-ACID; TOTAL ANTIOXIDANT CAPACITY; TYPE-2 DIABETES-MELLITUS;
   WEIGHT-LOSS; BODY-WEIGHT; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   HEALTH-BENEFITS; GLYCEMIC INDEX; LIVER-ENZYMES
AB The long-term effects of dietary strategies designed to combat the metabolic syndrome (MetS) remain unknown. The present study evaluated the effectiveness of a new dietary strategy based on macronutrient distribution, antioxidant capacity and meal frequency (MEtabolic Syndrome REduction in NAvarra (RESMENA) diet) for the treatment of the MetS when compared with the American Heart Association guidelines, used as Control. Subjects with the MetS (fifty-two men and forty-one women, age 49 (se 1) years, BMI 36.11 (se 0.5) kg/m(2)) were randomly assigned to one of two dietary groups. After a 2-month nutritional-learning intervention period, during which a nutritional assessment was made for the participants every 15d, a 4-month self-control period began. No significant differences were found between the groups concerning anthropometry, but only the RESMENA group exhibited a significant decrease in body weight (-1.7%; P=0.018), BMI (-1.7%; P=0.019), waist circumference (-1.8%; P=0.021), waist:hip ratio (-1.4%; P=0.035) and android fat mass (-6.9%; P=0.008). The RESMENA group exhibited a significant decrease in alanine aminotransferase and aspartate aminotransferase (AST) concentrations (-26.8%; P=0.008 and -14.0%; P=0.018, respectively), while the Control group exhibited a significant increase in glucose (7.9%; P=0.011), AST (11.3%; P=0.045) and uric acid (9.0%; P<0.001) concentrations. LDL-cholesterol (LDL-C) concentrations were increased (Control group: 34.4%; P<0.001 and RESMENA group: 33.8%; P<0.001), but interestingly so were the LDL-C:apoB ratio (Control group: 28.7%; P<0.001, RESMENA group: 17.1%; P=0.009) and HDL-cholesterol concentrations (Control group: 21.1%; P<0.001, RESMENA group: 8.7; P=0.001). Fibre was the dietary component that most contributed to the improvement of anthropometry, while body-weight loss explained changes in some biochemical markers. In conclusion, the RESMENA diet is a good long-term dietary treatment for the MetS.
C1 [de la Iglesia, Rocio; Lopez-Legarrea, Patricia; Bondia-Pons, Isabel; Navas-Carretero, Santiago; Alfredo Martinez, J.; Angeles Zulet, M.] Univ Navarra, Dept Nutr Food Sci & Physiol, E-31080 Pamplona, Spain.
   [Abete, Itziar] BioDonostia Hlth Res Inst, Dept Neurosci, San Sebastian, Spain.
   [Navas-Carretero, Santiago; Alfredo Martinez, J.; Angeles Zulet, M.] CIBERobn Centro Investigac Biomed Red Fisiopatol, Madrid, Spain.
   [Forga, Luis] Hosp Complex Navarra, Pamplona, Spain.
C3 University of Navarra; Instituto de Investigacion Sanitaria Biogipuzkoa;
   CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Servicio
   Navarro de Salud - Osasunbidea
RP Martinez, JA (corresponding author), Univ Navarra, Dept Nutr Food Sci & Physiol, E-31080 Pamplona, Spain.
EM jalfmtz@unav.es
RI de la Iglesia, Rocio/ABC-6189-2020; Abete, Itziar/H-4827-2017; Zulet, M.
   Angeles/H-1317-2017; Martinez Hernandez, J Alfredo/K-8709-2014;
   Navas-Carretero, Santiago/L-2918-2015
OI Abete, Itziar/0000-0002-6475-5387; Zulet, M.
   Angeles/0000-0002-3926-0892; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941; de la Iglesia, Rocio/0000-0002-7472-3565;
   Navas-Carretero, Santiago/0000-0002-5163-2230
FU Health Department of the Government of Navarra [48/2009]; Linea Especial
   about Nutrition, Obesity and Health (University of Navarra) [LE/97];
   CIBERobn scheme; RETICS scheme; Carlos III Health Institute [FI10/00587]
FX The present study was supported by the Health Department of the
   Government of Navarra (48/2009) and the Linea Especial about Nutrition,
   Obesity and Health (University of Navarra LE/97). The support from
   CIBERobn and RETICS schemes is gratefully acknowledged. Carlos III
   Health Institute provided a predoctoral grant to R.I (no. FI10/00587).
   None of the funding institutions and frameworks had a role in the design
   and analysis of the study or in writing of the article.
CR Abete I, 2010, NUTR REV, V68, P214, DOI 10.1111/j.1753-4887.2010.00280.x
   Abete I, 2009, INT J FOOD SCI NUTR, V60, P1, DOI 10.1080/09637480802232625
   Agnani Sujata, 2005, BMC Nephrol, V6, P7, DOI 10.1186/1471-2369-6-7
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Aller EEJG, 2011, NUTRIENTS, V3, P341, DOI 10.3390/nu3030341
   AMES BN, 1981, P NATL ACAD SCI-BIOL, V78, P6858, DOI 10.1073/pnas.78.11.6858
   Bahadoran Z, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-70
   Brownawell AM, 2012, J NUTR, V142, P962, DOI 10.3945/jn.112.158147
   Burton-Freeman B, 2000, J NUTR, V130, p272S, DOI 10.1093/jn/130.2.272S
   Carlsen MH, 2010, NUTR J, V9, DOI 10.1186/1475-2891-9-37
   Clifton PM, 2008, NAT CLIN PRACT GASTR, V5, P672, DOI 10.1038/ncpgasthep1283
   Clifton Peter M, 2007, Curr Atheroscler Rep, V9, P472, DOI 10.1007/s11883-007-0063-y
   CREPALDI G, 2005, METABOLIC SYNDROME B
   de Graaf C, 2004, AM J CLIN NUTR, V79, P946
   de la Iglesia R, 2013, INT J MOL SCI, V14, P6903, DOI 10.3390/ijms14046903
   Souto-Gallardo MD, 2011, NUTR HOSP, V26, P1242, DOI [10.3305/nh.2011.26.6.5244, 10.1590/S0212-16112011000600008]
   Du HD, 2010, AM J CLIN NUTR, V91, P329, DOI 10.3945/ajcn.2009.28191
   Ebbeling CB, 2012, JAMA-J AM MED ASSOC, V307, P2627, DOI 10.1001/jama.2012.6607
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Gao XA, 2007, HYPERTENSION, V50, P306, DOI 10.1161/HYPERTENSIONAHA.107.091041
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hamaguchi M, 2005, ANN INTERN MED, V143, P722, DOI 10.7326/0003-4819-143-10-200511150-00009
   Hermsdorff HHM, 2012, BRIT J NUTR, V107, P1119, DOI 10.1017/S0007114511004235
   Hermsdorff HHM, 2011, INFLAMMATION, V34, P161, DOI 10.1007/s10753-010-9219-y
   Howarth NC, 2001, NUTR REV, V59, P129, DOI 10.1111/j.1753-4887.2001.tb07001.x
   INGENIERIA A, 2011, DIAL PROGRAMME EVALU
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jaaskelainen A, 2012, NUTR METAB CARDIOVAS
   Jabary NS, 2006, NEFROLOGIA, V26, P64
   Jeemon P, 2013, CLIN SCI, V124, P255, DOI 10.1042/CS20120524
   Johnson RJ, 2011, SEMIN NEPHROL, V31, P394, DOI 10.1016/j.semnephrol.2011.08.002
   Kaczmarczyk MM, 2012, METABOLISM, V61, P1058, DOI 10.1016/j.metabol.2012.01.017
   Katcher HI, 2008, AM J CLIN NUTR, V87, P79, DOI 10.1093/ajcn/87.1.79
   Kerner A, 2005, ARTERIOSCL THROM VAS, V25, P193, DOI 10.1161/01.ATV.0000148324.63685.6a
   Kesse-Guyot E, 2013, NUTR METAB CARDIOVAS, V23, P677, DOI 10.1016/j.numecd.2012.02.005
   Kodama S, 2009, DIABETES CARE, V32, P1737, DOI 10.2337/dc09-0288
   König D, 2008, ANN NUTR METAB, V52, P74, DOI 10.1159/000119416
   Kristensen M, 2012, J NUTR, V142, P710, DOI 10.3945/jn.111.142315
   Larsen TM, 2010, NEW ENGL J MED, V363, P2102, DOI 10.1056/NEJMoa1007137
   Larson-Meyer DE, 2008, OBESITY, V16, P1355, DOI 10.1038/oby.2008.201
   Lemieux I, 2000, CIRCULATION, V102, P179, DOI 10.1161/01.CIR.102.2.179
   Livesey G., 1992, Nutrition Research Reviews, V5, P61, DOI 10.1079/NRR19920007
   Lonardo A, 2002, DIGEST LIVER DIS, V34, P204, DOI 10.1016/S1590-8658(02)80194-3
   Lopez-Huertas E, 2012, BRIT J NUTR, V107, pS185, DOI 10.1017/S0007114512001572
   Lopez-Legarrea P, 2013, NUTR METAB, V10, DOI 10.1186/1743-7075-10-22
   Masuo K, 2003, HYPERTENSION, V42, P474, DOI 10.1161/01.HYP.0000091371.53502.D3
   Moher D, 2012, INT J SURG, V10, P28, DOI 10.1016/j.ijsu.2011.10.001
   Navas-Carretero S, 2009, J PHYSIOL BIOCHEM, V65, P165, DOI 10.1007/BF03179067
   Navas-Carretero S, 2009, BRIT J NUTR, V102, P546, DOI 10.1017/S0007114509220794
   Parnell JA, 2012, GUT MICROBES, V3, P29, DOI 10.4161/gmic.19246
   Pereira MA, 2001, PEDIATR CLIN N AM, V48, P969, DOI 10.1016/S0031-3955(05)70351-5
   PEREZ S, 2005, ENFERMERIA CLIN, V15, P307
   Poppitt SD, 1996, APPETITE, V26, P153, DOI 10.1006/appe.1996.0013
   Puchau B, 2010, NUTRITION, V26, P534, DOI 10.1016/j.nut.2009.06.017
   REAVEN GM, 1993, ANNU REV MED, V44, P121, DOI 10.1146/annurev.med.44.1.121
   Rodríguez-Hernández H, 2011, ANN HEPATOL, V10, P486, DOI 10.1016/S1665-2681(19)31517-0
   RUBIO MA, 2005, METABOLIC SYNDROME B, P416
   Salmeron J, 1997, JAMA-J AM MED ASSOC, V277, P472, DOI 10.1001/jama.277.6.472
   Schulze MB, 2004, AM J CLIN NUTR, V80, P348, DOI 10.1093/ajcn/80.2.348
   Straznicky NE, 2012, DIABETES OBES METAB, V14, P139, DOI 10.1111/j.1463-1326.2011.01497.x
   Sundström J, 2005, HYPERTENSION, V45, P28, DOI 10.1161/01.HYP.0000150784.92944.9a
   Tani S, 2011, INT HEART J, V52, P343, DOI 10.1536/ihj.52.343
   Tzotzas T, 2011, OBES REV, V12, pe282, DOI 10.1111/j.1467-789X.2010.00807.x
   *U SYDN, 2012, GLYC IND
   Wanders AJ, 2011, OBES REV, V12, P724, DOI 10.1111/j.1467-789X.2011.00895.x
   Zijlstra N, 2009, AM J CLIN NUTR, V90, P269, DOI 10.3945/ajcn.2009.27694
   Zimmet P, 2005, REV ESP CARDIOL, V58, P1371, DOI 10.1016/S1885-5857(06)60742-1
   Zulet MA, 2011, NUTR HOSP, V26, P16, DOI 10.3305/nh.2011.26.1.5050
NR 69
TC 71
Z9 75
U1 0
U2 13
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD FEB 28
PY 2014
VL 111
IS 4
BP 643
EP 652
DI 10.1017/S0007114513002778
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AD0SE
UT WOS:000332943600009
PM 23968597
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Abplanalp, SJ
   Fulford, D
AF Abplanalp, Samuel J.
   Fulford, Daniel
TI Physical effort exertion and pain: Links with trait-based risk for
   psychopathology
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Serious mental illness; Schizotypy; Hypomania; Anhedonic depression;
   Clinical pain; Physical activity
ID MAJOR DEPRESSIVE DISORDER; SEVERE MENTAL-ILLNESS; BIPOLAR DISORDER;
   METABOLIC SYNDROME; TRIPARTITE MODEL; PEOPLE; SCHIZOPHRENIA; SCALE;
   METAANALYSIS; PERCEPTION
AB People with serious mental illness (SMI) are at an increased risk for physical health complications, such as cardiovascular disease and obesity. Low levels of physical activity is a major contributor to these health complications. One factor associated with limited physical activity in the broader sedentary population is pain. While preliminary findings suggest an association between lack of physical activity and pain in SMI, conclusions are still unclear. Thus, the goal of this correlational study was to examine associations between trait-based risk for psychopathology (hypomanic personality, schizotypy, and anhedonic depression) and the experience of pain following a physical endurance/effort task. Healthy participants (N = 43; 18 females) completed self-report measures of trait-based risk for psychopathology. They also reported on the experience of pain before and after the Time To Exhaustion (TTE) test. Findings revealed that risk for psychosis and anhedonic depression were associated with increases in pain following the TTE test, accounting for other key variables, such as age and self reported physical exercise. Risk for mania was unrelated to changes in pain. These results suggest that the experience of pain in relation to physical endurance/effort may contribute to diminished physical activity among people at risk for SMI.
C1 [Abplanalp, Samuel J.; Fulford, Daniel] Boston Univ, Sargent Coll, Coll Hlth & Rehabil Sci, Boston, MA 02215 USA.
   [Fulford, Daniel] Boston Univ, Dept Psychol & Brain Sci, Boston, MA 02215 USA.
C3 Boston University; Boston University
RP Abplanalp, SJ (corresponding author), Boston Univ, Sargent Coll, Coll Hlth & Rehabil Sci, Boston, MA 02215 USA.
EM samabp@bu.edu
CR Abplanalp SJ, 2017, PSYCHIAT RES, V255, P412, DOI 10.1016/j.psychres.2017.06.076
   Amann M, 2008, MED SCI SPORT EXER, V40, P574, DOI [10.1249/mss.0b013e31815e728f, 10.1249/MSS.0b013e31815e728f]
   [Anonymous], 2008, Physical Activity Guidelines Advisory Committee Report, 2008
   Atik L, 2007, ACTA NEUROPSYCHIATR, V19, P284, DOI 10.1111/j.1601-5215.2007.00193.x
   Bär KJ, 2005, PAIN, V117, P97, DOI 10.1016/j.pain.2005.05.016
   Birgenheir DG, 2013, GEN HOSP PSYCHIAT, V35, P480, DOI 10.1016/j.genhosppsych.2013.03.019
   Bredemeier K, 2010, PSYCHOL ASSESSMENT, V22, P702, DOI 10.1037/a0019915
   Callaway DA, 2014, PERSONAL DISORD, V5, P32, DOI 10.1037/per0000041
   Campellone TR, 2016, PSYCHIAT RES, V240, P181, DOI 10.1016/j.psychres.2016.04.020
   CHAPMAN LJ, 1994, J ABNORM PSYCHOL, V103, P171, DOI 10.1037/0021-843X.103.2.171
   CLARK LA, 1991, J ABNORM PSYCHOL, V100, P316, DOI 10.1037/0021-843X.100.3.316
   Cohen AS, 2010, J PERS DISORD, V24, P516, DOI 10.1521/pedi.2010.24.4.516
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   Dailey DL, 2015, ARTHRIT CARE RES, V67, P288, DOI 10.1002/acr.22417
   de Almeida JG, 2013, REV BRAS PSIQUIATR, V35, P13, DOI 10.1016/j.rbp.2011.11.003
   Dickens C, 2003, PSYCHOSOM MED, V65, P369, DOI 10.1097/01.PSY.0000041622.69462.06
   DWORKIN RH, 1995, PSYCHIAT RES, V56, P173, DOI 10.1016/0165-1781(95)02501-7
   ECKBLAD M, 1986, J ABNORM PSYCHOL, V95, P214, DOI 10.1037/0021-843X.95.3.214
   FERRAZ MB, 1990, J RHEUMATOL, V17, P1022
   Ferreira ML, 2012, J PHYSIOTHER, V58, P145, DOI 10.1016/S1836-9553(12)70105-4
   Firth J, 2016, PSYCHOL MED, V46, P2869, DOI 10.1017/S0033291716001732
   Gardner-Sood P, 2015, PSYCHOL MED, V45, P2619, DOI 10.1017/S0033291715000562
   Geneen L. J., 2017, COCHRANE DATABASE SY
   Girard M, 2011, CLIN J PAIN, V27, P790, DOI 10.1097/AJP.0b013e31821d904c
   Gureje O, 2008, PAIN, V135, P82, DOI 10.1016/j.pain.2007.05.005
   Hawker GA, 2011, ARTHRIT CARE RES, V63, pS240, DOI 10.1002/acr.20543
   Herr KA, 2004, CLIN J PAIN, V20, P207, DOI 10.1097/00002508-200407000-00002
   Koyanagi A, 2016, SCHIZOPHR RES, V175, P209, DOI 10.1016/j.schres.2016.04.031
   Kwapil TR, 2013, J ABNORM PSYCHOL, V122, P807, DOI 10.1037/a0033759
   Kwapil TR, 1998, J ABNORM PSYCHOL, V107, P558, DOI 10.1037/0021-843X.107.4.558
   Kwapil TR, 2000, J ABNORM PSYCHOL, V109, P222, DOI 10.1037//0021-843X.109.2.222
   Larson CO, 2002, HEALTH SERV RES, V37, P733, DOI 10.1111/1475-6773.00046
   Laursen TM, 2009, ARCH GEN PSYCHIAT, V66, P713, DOI 10.1001/archgenpsychiatry.2009.61
   Marcora SM, 2009, J APPL PHYSIOL, V106, P857, DOI 10.1152/japplphysiol.91324.2008
   McCormick A, 2015, SPORTS MED, V45, P997, DOI 10.1007/s40279-015-0319-6
   McIntosh T, 2016, J RES NURS, V21, P271, DOI 10.1177/1744987116647762
   Melzack R., 2005, Textbook of Pain
   Minichino A, 2016, BIPOLAR DISORD, V18, P591, DOI 10.1111/bdi.12439
   Okoro CA, 2014, PUBLIC HEALTH REP, V129, P30, DOI 10.1177/003335491412900106
   Parks J., 2006, Morbidity and mortality in people with serious mental illness
   Perez-Cruzado D, 2017, BMC SPORTS SCI MED R, V9, DOI 10.1186/s13102-017-0082-0
   Riddle DL, 2011, ARCH PHYS MED REHAB, V92, P859, DOI 10.1016/j.apmr.2011.01.003
   Salam H, 2018, EUR J APPL PHYSIOL, V118, P85, DOI 10.1007/s00421-017-3747-1
   Salokangas RKR, 2013, SOC PSYCH PSYCH EPID, V48, P303, DOI 10.1007/s00127-012-0545-2
   Simon GE, 2006, ARCH GEN PSYCHIAT, V63, P824, DOI 10.1001/archpsyc.63.7.824
   Stubbs B, 2016, ACTA PSYCHIAT SCAND, V134, P546, DOI 10.1111/acps.12654
   Stubbs B, 2015, ACTA PSYCHIAT SCAND, V131, P75, DOI 10.1111/acps.12325
   Stubbs B, 2018, SCHIZOPHR RES, V193, P412, DOI 10.1016/j.schres.2017.06.025
   Stubbs B, 2017, SCHIZOPHRENIA BULL, V43, P536, DOI 10.1093/schbul/sbw111
   Stubbs B, 2016, SCHIZOPHR RES, V176, P431, DOI 10.1016/j.schres.2016.05.017
   Stubbs B, 2015, PAIN, V156, P2121, DOI 10.1097/j.pain.0000000000000304
   Stubbs B, 2014, SCHIZOPHR RES, V160, P1, DOI 10.1016/j.schres.2014.10.017
   Thompson T, 2016, J PAIN, V17, P1257, DOI 10.1016/j.jpain.2016.08.007
   Trivedi Madhukar H, 2004, Prim Care Companion J Clin Psychiatry, V6, P12
   Vancampfort D, 2017, WORLD PSYCHIATRY, V16, P308, DOI 10.1002/wps.20458
   Vancampfort D, 2017, J AFFECT DISORDERS, V221, P81, DOI 10.1016/j.jad.2017.06.012
   Vancampfort D, 2016, WORLD PSYCHIATRY, V15, P166, DOI 10.1002/wps.20309
   Vancampfort D, 2016, GEN HOSP PSYCHIAT, V39, P15, DOI 10.1016/j.genhosppsych.2015.11.008
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Ware JE, 1996, MED CARE, V34, P220, DOI 10.1097/00005650-199603000-00003
   WATSON D, 1995, J ABNORM PSYCHOL, V104, P3, DOI 10.1037/0021-843X.104.1.3
NR 61
TC 4
Z9 4
U1 1
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD JAN
PY 2019
VL 271
BP 46
EP 51
DI 10.1016/j.psychres.2018.10.010
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HO1YZ
UT WOS:000460709900008
PM 30465981
DA 2025-06-11
ER

PT J
AU Shakil, SS
   Temu, TM
   Kityo, C
   Erem, G
   Bittencourt, MS
   Longenecker, CT
AF Shakil, Saate S.
   Temu, Tecla M.
   Kityo, Cissy
   Erem, Geoffrey
   Bittencourt, Marcio S.
   Longenecker, Chris T.
TI Circulating plasma NT-proBNP predicts subclinical coronary
   atherosclerosis on CT angiography among older adults in Uganda
SO BMC RESEARCH NOTES
LA English
DT Article
DE Cardiovascular disease; Coronary artery disease; Biomarkers; Myocardial
   stress
ID NATRIURETIC PEPTIDE
AB ObjectivePhenotypes and mechanisms of cardiovascular disease (CVD) may differ across global populations. In sub-Saharan Africa (SSA), distinct environmental determinants may influence development and progression of atherosclerotic coronary artery disease (CAD).MethodsWe investigated associations between 6 established markers of myocardial stress and subsequent subclinical CAD (sCAD), defined as presence of any atherosclerosis on coronary CT angiography (CCTA) in a 2-year prospective cohort of Ugandan adults enriched for cardiometabolic risk factors (RFs) and HIV. Six plasma biomarkers were measured baseline among 200 participants (50% with HIV) aged >= 45 years with >= 1 cardiovascular RF. At 2-year follow-up, 132 participants (52% with HIV) who returned underwent coronary CCTA.ResultsIn logistic regression models adjusted for cardiovascular RFs (age, diabetes, hypertension, hyperlipidemia, smoking, obesity) and non-traditional RFs (HIV, chronic kidney disease), only NT-proBNP predicted subsequent subclinical CAD (p < 0.008, Bonferroni correction for multiple testing). In sensitivity analyses adjusted for ASCVD risk category (instead of individual RFs) in the baseline cohort with multiple imputation applied to missing year 2 CCTA data (n = 200), NT-proBNP remained significantly associated with subsequent CAD (p < 0.008).ConclusionsNT-proBNP consistently predicted subclinical CAD in Uganda in the absence of such an association among other markers of myocardial stress, suggesting a role for NT-proBNP in atherosclerosis independently of coronary microvascular dysfunction.
C1 [Shakil, Saate S.] Univ Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94118 USA.
   [Temu, Tecla M.; Longenecker, Chris T.] Univ Washington, Dept Global Hlth, Med Ctr, Seattle, WA USA.
   [Kityo, Cissy] Joint Clin Res Ctr, Kampala, Uganda.
   [Erem, Geoffrey] Makerere Univ, Dept Radiol, Kampala, Uganda.
   [Bittencourt, Marcio S.] Univ Pittsburgh, Dept Radiol, Med Ctr, Pittsburgh, PA USA.
C3 University of California System; University of California San Francisco;
   University of Washington; University of Washington Seattle; Joint Clinic
   Research Center - United Arab Emirates; Makerere University;
   Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh
RP Shakil, SS (corresponding author), Univ Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94118 USA.
EM saate.shakil@ucsf.edu
RI Bittencourt, Marcio/C-1444-2011
OI Kityo, Cissy/0000-0002-9286-7052; Longenecker, Chris/0000-0002-9468-0179
FU National Institutes of Health [T32HL007828, 1K01HL147723, P30AI027757,
   K23HL123341]
FX This work was supported in part by the National Institutes of Health
   (T32HL007828 to SSS, 1K01HL147723 and P30AI027757 to TMT, and
   K23HL123341 to CTL).
CR Alencherry B, 2019, OPEN HEART, V6, DOI 10.1136/openhrt-2019-001046
   Dirajlal-Fargo S, 2015, AIDS, V29, P313, DOI 10.1097/QAD.0000000000000547
   Goff DC Jr, 2014, CIRCULATION, V129, pS49, DOI 10.1161/01.cir.0000437741.48606.98
   Hirakawa K, 2017, INT J CARDIOL, V228, P881, DOI 10.1016/j.ijcard.2016.11.054
   Huaman MA, 2021, CLIN INFECT DIS, V73, pE3384, DOI 10.1093/cid/ciaa1934
   Jones E, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0243213
   Kipke J, 2021, J AM HEART ASSOC, V10, DOI 10.1161/JAHA.120.018767
   Longenecker CT, 2022, J INT AIDS SOC, V25, DOI 10.1002/jia2.25868
   Otieno P, 2023, BMJ OPEN, V13, DOI 10.1136/bmjopen-2022-064275
   Shakil SS, 2023, AIDS, V37, P579, DOI 10.1097/QAD.0000000000003451
   Shakil SS, 2022, CIRC-CARDIOVASC QUAL, V15, DOI 10.1161/CIRCOUTCOMES.122.009046
NR 11
TC 0
Z9 0
U1 0
U2 0
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 1756-0500
J9 BMC RES NOTES
JI BMC Res. Notes
PD JUN 19
PY 2023
VL 16
IS 1
AR 107
DI 10.1186/s13104-023-06385-0
PG 6
WC Biology; Multidisciplinary Sciences
WE Emerging Sources Citation Index (ESCI)
SC Life Sciences & Biomedicine - Other Topics; Science & Technology - Other
   Topics
GA J6PX9
UT WOS:001010829700003
PM 37337285
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nakamura, K
   Yamagishi, S
   Inoue, H
AF Nakamura, K
   Yamagishi, S
   Inoue, H
TI Unique atheroprotective property of azeinidipine, a
   dihydropyridine-based calcium antagonist
SO MEDICAL HYPOTHESES
LA English
DT Article
ID INSULIN-RESISTANCE; ALPHA; STRESS
AB Insulin resistance and central obesity are often associated with hypertension. The metabolic syndrome is a cluster of these common clinical disorders, and is related with an increased risk for cardiovascular diseases. A number of pro-inflammatory cytokines derived from adipose tissues have been thought to contribute to the development of insulin resistance and accelerated atherosclerosis. Among them, TNF-alpha has been most widely studied; it not only suppresses the insulin signaling, but also elicits vascular inflammation. Indeed, inhibition of TNF-alpha was found to improve insulin resistance in obese rats and reduce the progression of atherosclerosis in apolipoprotein E knockout mice, respectively. These observations demonstrate that TNF-alpha could play a central role in the pathogenesis of insulin resistance and accelerated atherosclerosis in the metabolic syndrome. Considering that the primary goals of treatment for hypertensive patients with the metabolic syndrome are prevention of the development of diabetes and cardiovascular events, anti-hypertensive drugs that have abilities to block the TNF-alpha signaling would be desirable as a first-line therapy for these patients. In the process of the search for such a unique anti-hypertensive drug, we have recently found that azelnidipine, a newly developed and commercially used long-acting dihydropyridine-based calcium antagonist (DHP), inhibited TNF-alpha-induced activator protein-1 activation and interteukin-8 expression in human umbilical vein endothelial cells by suppressing NADPH oxidase-mediated reactive oxygen species generation. The concentration of azelnidipine that was found effective in these in vitro-experiments is well within the therapeutic range. Since endothelial cells do not possess voltage-operated L-type calcium channels, these observations suggest that the beneficial effects of azelnidipine are not likely due to calcium channel blocking property, but due to its unique anti-oxidative ability. Furthermore, we have very recently found that serum levels of monocyte chemoattractant protein-1, a biomarker for subclinical atherosclerosis, were significantly decreased by the treatment of azelnidipine in patients with essential hypertension. In this paper, we would like to hypothesize that due to its unique TNF-alpha signal modulatory, anti-oxidative property, azelnidipine may be a promising DHP that targets diabetes and cardiovascular diseases in hypertensive patients with the metabolic syndrome. (c) 2005 Elsevier Ltd. All rights reserved.
C1 Kurume Univ, Sch Med, Dept Med, Kurume, Fukuoka 8300011, Japan.
   Kurume Univ, Sch Med, Radioisotope Inst Basic & Clin Med, Kurume, Fukuoka 8300011, Japan.
C3 Kurume University; Kurume University
RP Kurume Univ, Sch Med, Dept Med, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
EM shoichi@med.kurume-u.ac.jp
CR Borst SE, 2004, ENDOCRINE, V23, P177, DOI 10.1385/ENDO:23:2-3:177
   Branén L, 2004, ARTERIOSCL THROM VAS, V24, P2137, DOI 10.1161/01.ATV.0000143933.20616.1b
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Deo R, 2004, J AM COLL CARDIOL, V44, P1812, DOI 10.1016/j.jacc.2004.07.047
   Fernández-Real JM, 2003, ENDOCR REV, V24, P278, DOI 10.1210/er.2002-0010
   Gerszten RE, 1999, NATURE, V398, P718, DOI 10.1038/19546
   HOTAMISLIGIL GS, 1994, P NATL ACAD SCI USA, V91, P4854, DOI 10.1073/pnas.91.11.4854
   Laight DW, 1999, EUR J PHARMACOL, V377, P89, DOI 10.1016/S0014-2999(99)00407-0
   Scheen A J, 2004, Minerva Endocrinol, V29, P31
   Sowers JR, 2004, AM J PHYSIOL-HEART C, V286, pH1597, DOI 10.1152/ajpheart.00026.2004
   Watson Karol E., 2003, Journal of Cardiovascular Pharmacology and Therapeutics, V8, P253, DOI 10.1177/107424840300800402
   Wisse BE, 2004, J AM SOC NEPHROL, V15, P2792, DOI 10.1097/01.ASN.0000141966.69934.21
   Yamagishi S, 2004, J CARDIOVASC PHARM, V43, P724, DOI 10.1097/00005344-200405000-00016
   YEU TL, 1994, CIRC RES, V75, P1
NR 14
TC 9
Z9 13
U1 0
U2 1
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PY 2005
VL 65
IS 1
BP 155
EP 157
DI 10.1016/j.mehy.2004.12.007
PG 3
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 932DW
UT WOS:000229535400027
PM 15893134
DA 2025-06-11
ER

PT J
CA FLAT-SUGAR Trial Investigators
TI Glucose Variability in a 26-Week Randomized Comparison of Mealtime
   Treatment With Rapid-Acting Insulin Versus GLP-1 Agonist in Participants
   With Type 2 Diabetes at High Cardiovascular Risk
SO DIABETES CARE
LA English
DT Article
ID RECEPTOR AGONIST; BASAL INSULIN; OPEN-LABEL; EXENATIDE; COMPLICATIONS;
   METFORMIN; TRIAL; TWICE
AB OBJECTIVEA1C is associated with diabetes complications but does not reflect glycemic variability (GV), which may worsen outcomes by inducing inflammation, oxidative stress, and cardiac arrhythmias. We tested whether a glucagon-like peptide 1 agonist-based regimen can reduce GV and cardiometabolic risk markers while maintaining similar A1C levels in people with insulin-requiring type 2 diabetes and high cardiovascular risk.RESEARCH DESIGN AND METHODSAfter run-in on metformin and basal-bolus insulin (BBI), 102 participants continued metformin and basal insulin and were randomized to exenatide dosing before the two largest meals (glucacon-like peptide-1 receptor agonist and insulin [GLIPULIN group]) or continuation of rapid-acting insulin analogs (BBI group). Indices of GV by continuous glucose monitoring (CGM), hypoglycemia, weight, risk markers, and cardiac arrhythmias were assessed. The primary end point was change in glucose coefficients of variation (CV) by CGM from baseline to 26 weeks.RESULTSAt randomization, the median A1C was 7.3% (57 mmol/mol) for GLIPULIN and 7.4% (56.3 mmol/mol) for BBI, and glucose CVs were 30.3 for BBI and 31.9 for GLIPULIN. At 26 weeks, A1C levels were similar (7.1% [54 mmol/mol] vs. 7.2% [55 mmol/mol]), whereas mean CV improved with GLIPULIN (-2.4 vs. 0.4, P = 0.047). Other GV indices followed similar nonsignificant patterns of improvement with GLIPULIN. There were no differences in hypoglycemic events during CGM or arrhythmias during electrocardiographic monitoring. On-trial changes in body weight (-4.8 kg vs. +0.7 kg, P < 0.001), alanine aminotransferase (P = 0.0002), and serum amyloid A (P = 0.023) favored GLIPULIN.CONCLUSIONSGLIPULIN reduced GV, weight, and some cardiometabolic risk markers while maintaining equivalent A1C levels versus BBI and might improve clinical outcomes in a larger trial.
RI O'Brien, Kevin/HDO-1461-2022
OI O'Brien, Kevin/0000-0002-2293-9196
FU Sanofi; Clinical Trials Service Unit of the University of Washington;
   Bristol-Myers Squibb-AstraZeneca; Eli Lilly; Bayer; Halozyme;
   AstraZeneca; Novo Nordisk
FX This study is an investigator-initiated clinical trial primarily funded
   by a grant from Sanofi. A contract was developed between Sanofi and the
   Clinical Trials Service Unit of the University of Washington, which
   became the academic sponsor of the study. Supplemental funding was
   provided later in the study by grants from Bristol-Myers
   Squibb-AstraZeneca and Sanofi. In-kind donations were provided for the
   study by several organizations, including Sanofi (donated insulin
   glargine [Lantus] and insulin glulisine [Apidra] and purchased insulin
   aspart [NovoLog]), Eli Lilly (donated insulin lispro [Humalog]),
   Amylin/Bristol-Myers Squibb-AstraZeneca (donated exenatide [Byetta]),
   Bayer (donated Contour Glucose Meters, strips, and supplies), Becton
   Dickinson (donated pen needles), Dexcom (donated the various components
   of the CGM devices [Seven Plus and Gen 4]), and Medicomp (donated Holter
   monitoring equipment and supported reading of the recordings). J.L.P.
   reports honoraria for consulting from Sanofi and research grant support
   from Sanofi, Bristol-Myers Squibb-AstraZeneca, Eli Lilly, and Bayer.
   These dualities of interest have been reviewed by the University of
   Washington. The FLAT-SUGAR Trial Investigators report receiving
   honoraria for consulting from Roche, Abbott Diabetes Care, and Becton
   Dickinson and receiving grants from Sanofi and Halozyme. R.B. reports
   receiving honoraria for consulting and lectures from Abbott Diabetes
   Care, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb-AstraZeneca,
   Calibra, Eli Lilly, Halozyme, Hygieia, Johnson & Johnson, Medtronic,
   Novo Nordisk, Roche, Sanofi, Takeda, and Valeritas. C.K. reports having
   received grant support from Sanofi and Bristol-Myers Squibb-AstraZeneca.
   D.K. and K.R.B. report having received grant support from Sanofi. M.R.
   reports having received grant support from Sanofi, AstraZeneca, Eli
   Lilly, and Novo Nordisk; honoraria for speaking from Sanofi; and
   honoraria for consulting from Sanofi, AstraZeneca, Eli Lilly, Elcelyx,
   Valeritas, and Biodol; these dualities of interest have been reviewed
   and managed by Oregon Health & Science University. K.D.O. reports having
   received grant support from Sanofi for this study. No other potential
   conflicts of interest relevant to this article were reported.
CR [Anonymous], NEW ENGL J MED
   Buse JB, 2009, LANCET, V374, P39, DOI 10.1016/S0140-6736(09)60659-0
   Cervera A, 2008, AM J PHYSIOL-ENDOC M, V294, pE846, DOI 10.1152/ajpendo.00030.2008
   Chow E, 2014, DIABETES, V63, P1738, DOI 10.2337/db13-0468
   Diamant M, 2014, DIABETES CARE, V37, P2763, DOI 10.2337/dc14-0876
   Drucker DJ, 2008, LANCET, V372, P1240, DOI 10.1016/S0140-6736(08)61206-4
   Duckworth W, 2009, NEW ENGL J MED, V360, P129, DOI 10.1056/NEJMoa0808431
   Garg SK, 2009, DIABETES CARE, V32, P436, DOI 10.2337/dc08-1745
   Gerstein HC, 2008, NEW ENGL J MED, V358, P2545, DOI 10.1056/NEJMoa0802743
   Hirsch IB, 2015, DIABETES CARE, V38, P1610, DOI 10.2337/dc14-2898
   Holman RR, 2008, NEW ENGL J MED, V359, P1577, DOI 10.1056/NEJMoa0806470
   Nematollahi LR, 2009, METABOLISM, V58, P443, DOI 10.1016/j.metabol.2008.10.018
   Orchard TJ, 2015, JAMA-J AM MED ASSOC, V313, P45, DOI 10.1001/jama.2014.16107
   Poon Terri, 2005, Diabetes Technol Ther, V7, P467, DOI 10.1089/dia.2005.7.467
   Probstfield JL, 2015, DIABETES CARE, V38, P1558, DOI 10.2337/dc14-2689
   Ratner RE, 2010, DIABETIC MED, V27, P1024, DOI 10.1111/j.1464-5491.2010.03020.x
   Rodbard David, 2012, J Diabetes Sci Technol, V6, P712
   SHAMOON H, 1993, NEW ENGL J MED, V329, P977, DOI 10.1056/NEJM199307293290502
   Turner RC, 1998, LANCET, V352, P837, DOI 10.1016/s0140-6736(98)07019-6
   Uccellatore A, 2015, DIABETES THER, V6, P239, DOI 10.1007/s13300-015-0127-x
NR 20
TC 90
Z9 90
U1 0
U2 7
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD JUN
PY 2016
VL 39
IS 6
BP 973
EP 981
DI 10.2337/dc15-2782
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DN3RJ
UT WOS:000376980500023
PM 27208320
DA 2025-06-11
ER

PT J
AU Bo, S
   Musso, G
   Gambino, R
   Villois, P
   Gentile, L
   Durazzo, M
   Cavallo-Perin, P
   Cassader, M
AF Bo, Simona
   Musso, Giovanni
   Gambino, Roberto
   Villois, Paola
   Gentile, Luigi
   Durazzo, Marilena
   Cavallo-Perin, Paolo
   Cassader, Maurizio
TI Prognostic implications for insulin-sensitive and insulin-resistant
   normal-weight and obese individuals from a population-based cohort
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID BODY-MASS INDEX; JAPANESE METABOLICALLY OBESE; HOMEOSTASIS MODEL
   ASSESSMENT; CARDIOVASCULAR RISK PROFILE; OXIDATIVE STRESS; HEALTHY;
   PREVALENCE; PHENOTYPES; DISEASE; GLUCOSE
AB Background: There are few prospective data on the prognosis of insulin-sensitive and insulin-resistant normal-weight (NW) or obese individuals.
   Objectives: The estimated liver fat content, incidences of hyperglycemia and cardiovascular disease, and all-cause and cardiovascular mortality rates were investigated in a population-based cohort of 1658 individuals who were categorized according to BMI and insulin resistance as defined by HOMA-IR values >= 2.5 and the presence of metabolic syndrome.
   Design: This was a prospective cohort study with a 9-y follow-up. Anthropometric values, blood pressure, and blood metabolic variables were measured, and information on vital status was collected from demographic files at follow-up.
   Results: A total of 137 of 677 NW individuals (20%) were classified as insulin resistant and normal weight (IR-NW), and 72 of 330 obese individuals (22%) were classified as insulin sensitive and obese (IS-obese). Incidences of diabetes, impaired fasting glucose, and cardiovascular events were 0.4%, 6.3%, and 3.3%, respectively, in insulin-sensitive and normal-weight (IS-NW) individuals (reference category); 5.8%, 10.2%, and 6.6%, respectively, in IR-NW individuals; and 5.6%, 8.3%, and 8.3%, respectively, in IS-obese individuals. In a multiple logistic regression model, risks of incident hyperglycemia and cardiovascular events increased in both groups compared with in the reference category [HR (95% CI): 2.54 (1.42, 4.55) and 1.98 (0.86, 4.54) in IR-NW subjects; 2.16 (1.01, 4.63) and 2.76 (1.05, 7.28) in IS-obese subjects]. The estimated liver fat content significantly increased during follow-up only in the IR-NW group in the same model. Cardiovascular mortality was 2-3-fold higher in IR-NW and IS-obese than in IS-NW individuals in a Cox regression model.
   Conclusions: Our data refute the existence of healthy obese phenotypes because IS-obese individuals showed increased cardiometabolic risk. The existence of unhealthy NW phenotypes is supported by their increased risk of incident hyperglycemia, fatty liver, cardiovascular events, and death. Am J Clin Nutr 2012;96:962-9.
C1 [Bo, Simona; Gambino, Roberto; Villois, Paola; Durazzo, Marilena; Cavallo-Perin, Paolo; Cassader, Maurizio] Univ Turin, Dept Internal Med, Corso Dogliotti 14, I-10126 Turin, Italy.
   [Musso, Giovanni] Gradenigo Hosp, Turin, Italy.
   [Gentile, Luigi] Hosp Asti, Diabet Clin, Asti, Italy.
C3 University of Turin; Humanitas Hospital Gradenigo
RP Bo, S (corresponding author), Univ Turin, Dept Internal Med, Corso Dogliotti 14, I-10126 Turin, Italy.
EM sbo@molinette.piemonte.it
RI Bo, Simona/AAC-1110-2019; GAMBINO, Roberto/AAC-7517-2022; Musso,
   Giovanni/AAB-7884-2022
OI DURAZZO, Marilena/0000-0003-2450-5911; Bo, Simona/0000-0001-6862-8628
FU Regione Piemonte
FX Supported by a grant from the Regione Piemonte, 2009.
CR Aguilar-Salinas CA, 2008, J CLIN ENDOCR METAB, V93, P4075, DOI 10.1210/jc.2007-2724
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
   [Anonymous], INT J OBES LOND
   Ärnlöv J, 2010, CIRCULATION, V121, P230, DOI 10.1161/CIRCULATIONAHA.109.887521
   Bellentani S, 2000, ANN INTERN MED, V132, P112, DOI 10.7326/0003-4819-132-2-200001180-00004
   Bo S, 2005, DIABETES-METAB RES, V21, P515, DOI 10.1002/dmrr.561
   Bo S, 2006, AM J CLIN NUTR, V84, P1062, DOI 10.1093/ajcn/84.5.1062
   Bonora E, 2000, DIABETES CARE, V23, P57, DOI 10.2337/diacare.23.1.57
   Brochu M, 2001, J CLIN ENDOCR METAB, V86, P1020, DOI 10.1210/jc.86.3.1020
   Calori G, 2011, DIABETES CARE, V34, P210, DOI 10.2337/dc10-0665
   Conus F, 2004, J CLIN ENDOCR METAB, V89, P5013, DOI 10.1210/jc.2004-0265
   D'Agostino RB, 2008, CIRCULATION, V117, P743, DOI 10.1161/CIRCULATIONAHA.107.699579
   De Lorenzo A, 2007, AM J CLIN NUTR, V85, P40, DOI 10.1093/ajcn/85.1.40
   Dvorak RV, 1999, DIABETES, V48, P2210, DOI 10.2337/diabetes.48.11.2210
   He Y, 2007, DIABETES CARE, V30, P2128, DOI 10.2337/dc06-2402
   Hyun YJ, 2008, OBESITY, V16, P784, DOI 10.1038/oby.2007.127
   Iacobellis G, 2005, OBES RES, V13, P1116, DOI 10.1038/oby.2005.130
   Jennings CL, 2008, OBESITY, V16, P1602, DOI 10.1038/oby.2008.233
   Karelis A, 2004, DIABETES METAB, V30, P569, DOI 10.1016/S1262-3636(07)70156-8
   Karelis AD, 2004, J CLIN ENDOCR METAB, V89, P2569, DOI 10.1210/jc.2004-0165
   Katsuki A, 2003, DIABETES CARE, V26, P2341, DOI 10.2337/diacare.26.8.2341
   Katsuki A, 2006, DIABETES RES CLIN PR, V73, P310, DOI 10.1016/j.diabres.2006.02.014
   Khan UI, 2011, ATHEROSCLEROSIS, V217, P179, DOI 10.1016/j.atherosclerosis.2011.01.007
   Kip KE, 2004, CIRCULATION, V109, P706, DOI 10.1161/01.CIR.0000115514.44135.A8
   Kotronen A, 2009, GASTROENTEROLOGY, V137, P865, DOI 10.1053/j.gastro.2009.06.005
   Kroke A, 1999, AM J CLIN NUTR, V70, P439
   Kuk JL, 2009, DIABETES CARE, V32, P2297, DOI 10.2337/dc09-0574
   Lee SH, 2011, CLIN ENDOCRINOL, V75, P475, DOI 10.1111/j.1365-2265.2011.04085.x
   Marini MA, 2007, DIABETES CARE, V30, P2145, DOI 10.2337/dc07-0419
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McLaughlin T, 2007, ARCH INTERN MED, V167, P642, DOI 10.1001/archinte.167.7.642
   Meigs JB, 2007, DIABETES CARE, V30, P2529, DOI 10.2337/dc07-0817
   Meigs JB, 2006, J CLIN ENDOCR METAB, V91, P2906, DOI 10.1210/jc.2006-0594
   Musso G, 2011, ANN MED, V43, P617, DOI 10.3109/07853890.2010.518623
   Ogorodnikova AD, 2012, OBESITY, V20, P651, DOI 10.1038/oby.2011.243
   Pajunen P, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-754
   Park J, 2011, J HYPERTENS, V29, P1765, DOI 10.1097/HJH.0b013e32834a50f3
   Pataky Z, 2011, INT J OBESITY, V35, P1208, DOI 10.1038/ijo.2010.264
   Pi-Sunyer FX, 1998, OBES RES, V6, p51S
   Ruderman N, 1998, DIABETES, V47, P699, DOI 10.2337/diabetes.47.5.699
   St-Pierre AC, 2005, CAN MED ASSOC J, V172, P1301, DOI 10.1503/cmaj.1040834
   Stefan N, 2008, ARCH INTERN MED, V168, P1609, DOI 10.1001/archinte.168.15.1609
   Succurro E, 2008, OBESITY, V16, P1881, DOI 10.1038/oby.2008.308
   TAYLOR HL, 1978, J CHRON DIS, V31, P741, DOI 10.1016/0021-9681(78)90058-9
   Velho S, 2010, EUR J CLIN NUTR, V64, P1043, DOI 10.1038/ejcn.2010.114
   Wildman RP, 2008, ARCH INTERN MED, V168, P1617, DOI 10.1001/archinte.168.15.1617
   Wildman RP, 2011, OBESITY, V19, P1482, DOI 10.1038/oby.2010.332
   WILLETT W, 1986, AM J EPIDEMIOL, V124, P17, DOI 10.1093/oxfordjournals.aje.a114366
NR 49
TC 46
Z9 48
U1 0
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD NOV
PY 2012
VL 96
IS 5
BP 962
EP 969
DI 10.3945/ajcn.112.040006
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 062UX
UT WOS:000312949600004
PM 23034958
OA Bronze
DA 2025-06-11
ER

PT J
AU Cabre, HE
   Woolf, EK
   Redman, LM
AF Cabre, Hannah E.
   Woolf, Emily K.
   Redman, Leanne M.
TI Precision Nutrition for Management of Cardiovascular Disease Risk during
   Menopause
SO LIFESTYLE GENOMICS
LA English
DT Review
DE Perimenopause; Postmenopause; Dietary Approaches to Stop Hypertension;
   Mediterranean diet; Diabetes
ID LOW-FAT; BODY-COMPOSITION; WOMENS HEALTH; WEIGHT-LOSS; CARBOHYDRATE
   DIETS; MEDITERRANEAN DIET; TRANSITION; ASSOCIATION; OBESITY;
   INTERVENTION
AB Background: Women can spend up to 40% of their lives in the postmenopausal state. As women begin to transition into menopause, known as perimenopause, changes in hormonal concentrations and body composition dramatically increase overall cardiometabolic risk. Dietary patterns and interventions can be utilized to prevent and treat cardiovascular disease (CVD) and some dietary patterns over others may be more beneficial due to their specific effects on the health aspects of menopause. In this narrative review, we summarize key cardiovascular alterations that occur during the menopause transition and explore current dietary recommendations to address CVD risk as well as explore the new frontier of precision nutrition and the implications for nutrition prescription during menopause. Summary: Popular dietary interventions for CVD such as the Dietary Approaches to Stop Hypertension (DASH) diet and the Mediterranean diet (MED) have limited data in women following menopause. However, both diets improve CVD risk biomarkers of total cholesterol and low-density lipoprotein cholesterol as well as lower oxidative stress and inflammation and improve endothelial function. As the menopause transition increases the risk for developing metabolic syndrome, insulin insensitivity, and dyslipidemia, the DASH diet and MED may be impactful dietary strategies for mediating CVD risk in menopausal women. However, these are "one-size-fits-all" approaches that neglect individual characteristics such as genetic predisposition and environmental factors. Precision nutrition considers individual factors for nutrition prescription, spanning from evaluating food intake preferences and behaviors to deep phenotyping. Data from a large-scale investigation of the menopause transition suggests nutritional strategies that address postprandial glycemic responses, and the gut microbiome may attenuate some of the unfavorable effects of menopause on CVD risk factors. Key Messages: Considering menopause, women are a clinical population that would greatly benefit from precision nutrition. Future research should explore the use of machine learning and artificial intelligence in a precision nutrition framework to modify the DASH diet and MED to address adverse effects that occur during the menopause transition are vital for supporting women's health as they age. (c) 2024 The Author(s).Published by S. Karger AG, Basel
C1 [Cabre, Hannah E.; Woolf, Emily K.; Redman, Leanne M.] Pennington Biomed Res Ctr, Reprod Endocrinol & Womens Hlth Lab, Baton Rouge, LA 70808 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center
RP Redman, LM (corresponding author), Pennington Biomed Res Ctr, Reprod Endocrinol & Womens Hlth Lab, Baton Rouge, LA 70808 USA.
EM leanne.redman@pbrc.edu
RI Cabre, Hannah/NDT-4907-2025; Redman, Leanne/N-1986-2017
FU National Institute of Diabetes and Digestive and Kidney Diseases of the
   National Institutes of Health [T32DK064584]; Eunice Kennedy Shriver
   National Institute of Child Health and Human Development
   [5UG1HD107696-03]
FX Research reported in this publication was supported by the National
   Institute of Diabetes and Digestive and Kidney Diseases of the National
   Institutes of Health under Award No. T32DK064584 and Eunice Kennedy
   Shriver National Institute of Child Health and Human Development under
   Award No. 5UG1HD107696-03. The content is solely the responsibility of
   the authors and does not necessarily represent the official views of the
   National Institutes of Health. The funders had no role in the design,
   data collection, data analysis, and reporting of this review.
CR Acosta A, 2021, OBESITY, V29, P662, DOI 10.1002/oby.23120
   Amiri M, 2022, MATURITAS, V155, P40, DOI 10.1016/j.maturitas.2021.10.001
   Arnett DK, 2019, CIRCULATION, V140, pE563, DOI [10.1016/j.jacc.2019.03.009, 10.1016/j.jacc.2019.03.010, 10.1161/CIR.0000000000000678, 10.1161/CIR.0000000000000677]
   Barnard ND, 2005, AM J MED, V118, P991, DOI 10.1016/j.amjmed.2005.03.039
   Barrea L, 2021, CRIT REV FOOD SCI, V61, P1201, DOI 10.1080/10408398.2020.1755220
   Bermingham KM, 2022, EBIOMEDICINE, V85, DOI 10.1016/j.ebiom.2022.104303
   Berrino F, 2001, CANCER EPIDEM BIOMAR, V10, P25
   Cabre HE, 2024, METABOLITES, V14, DOI 10.3390/metabo14070347
   Cabre HE, 2022, CLIN PHYSIOL FUNCT I, V42, P460, DOI 10.1111/cpf.12771
   Cornier MA, 2005, OBES RES, V13, P703, DOI 10.1038/oby.2005.79
   de Toro-Martín J, 2017, NUTRIENTS, V9, DOI 10.3390/nu9080913
   Dinh QN, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/406960
   Ebbeling CB, 2007, JAMA-J AM MED ASSOC, V297, P2092, DOI 10.1001/jama.297.19.2092
   El Khoudary SR, 2020, CIRCULATION, V142, pe506, DOI 10.1161/CIR.0000000000000912
   El Khoudary SR, 2019, MENOPAUSE, V26, P1213, DOI 10.1097/GME.0000000000001424
   Fatima K, 2023, IRISH J MED SCI, V192, P105, DOI 10.1007/s11845-022-02944-9
   Flor-Alemany M, 2020, MATURITAS, V137, P30, DOI 10.1016/j.maturitas.2020.04.002
   Frankenfeld CL, 2014, EUR J CLIN NUTR, V68, P526, DOI 10.1038/ejcn.2014.23
   Gardner CD, 2018, JAMA-J AM MED ASSOC, V319, P667, DOI 10.1001/jama.2018.0245
   Gold EB, 2006, AM J PUBLIC HEALTH, V96, P1226, DOI 10.2105/AJPH.2005.066936
   Gould LM, 2022, MENOPAUSE, V29, P377, DOI 10.1097/GME.0000000000001932
   Greendale GA, 2020, J CLIN ENDOCR METAB, V105, DOI 10.1210/clinem/dgz056
   Grisotto G, 2022, MENOPAUSE, V29, P861, DOI 10.1097/GME.0000000000001985
   Harlow SD, 2018, OBSTET GYN CLIN N AM, V45, P599, DOI 10.1016/j.ogc.2018.07.003
   Höchsmann C, 2023, NAT COMMUN, V14, DOI 10.1038/s41467-023-41969-1
   Hsia J, 2007, CIRCULATION, V115, P855, DOI 10.1161/CIRCULATIONAHA.106.656850
   Janssen I, 2008, ARCH INTERN MED, V168, P1568, DOI 10.1001/archinte.168.14.1568
   Jeppesen J, 1997, AM J CLIN NUTR, V65, P1027, DOI 10.1093/ajcn/65.4.1027
   Kravitz HM, 2018, OBSTET GYN CLIN N AM, V45, P679, DOI 10.1016/j.ogc.2018.07.008
   Kurrelmeyer Karla, 2017, Methodist Debakey Cardiovasc J, V13, P183, DOI 10.14797/mdcj-13-4-183
   Lovejoy JC, 2008, INT J OBESITY, V32, P949, DOI 10.1038/ijo.2008.25
   Maas AHEM, 2021, EUR HEART J, V42, P967, DOI 10.1093/eurheartj/ehaa1044
   Marín C, 2013, INT J MOL SCI, V14, P8869, DOI 10.3390/ijms14058869
   Marin C, 2011, AM J CLIN NUTR, V93, P267, DOI 10.3945/ajcn.110.006866
   Marlatt KL, 2022, OBESITY, V30, P14, DOI 10.1002/oby.23289
   Marlatt KL, 2020, AM J OBSTET GYNECOL, V222, DOI 10.1016/j.ajog.2019.09.051
   Minkin MJ, 2019, OBSTET GYN CLIN N AM, V46, P501, DOI 10.1016/j.ogc.2019.04.008
   Moore SR, 2024, MENOPAUSE, V31, P336, DOI 10.1097/GME.0000000000002334
   Moreau KL, 2020, GEROSCIENCE, V42, P1699, DOI 10.1007/s11357-020-00236-7
   Moreau KL, 2012, J CLIN ENDOCR METAB, V97, P4692, DOI 10.1210/jc.2012-2244
   Moreau KL., 2014, Adv Vasc Med, V2014, P1, DOI DOI 10.1155/2014/204390
   Namazi M, 2019, INT J WOMENS HEALTH, V11, P637, DOI 10.2147/IJWH.S228594
   Nowson CA, 2009, NUTR RES, V29, P8, DOI 10.1016/j.nutres.2008.12.002
   Onwuzo C, 2023, CUREUS J MED SCIENCE, V15, DOI 10.7759/cureus.44692
   Rossi R, 2008, J AM COLL CARDIOL, V51, P997, DOI 10.1016/j.jacc.2007.11.044
   Segal-Isaacson CJ, 2004, OBES RES, V12, p130S, DOI 10.1038/oby.2004.278
   Siervo M, 2015, BRIT J NUTR, V113, P1, DOI 10.1017/S0007114514003341
   Silva TR, 2021, NUTRIENTS, V13, DOI 10.3390/nu13072149
   Stanton MV, 2017, CONTEMP CLIN TRIALS, V53, P151, DOI 10.1016/j.cct.2016.12.021
   Williams CM, 2013, P NUTR SOC, V72, P407, DOI 10.1017/S0029665113002048
   Woolf EK, 2023, NUTR RES, V120, P20, DOI 10.1016/j.nutres.2023.09.007
   Woolf EK, 2023, FOOD FUNCT, V14, P2621, DOI [10.1039/d3fo00157a, 10.1039/D3FO00157A]
NR 52
TC 1
Z9 1
U1 5
U2 7
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 2504-3161
EI 2504-3188
J9 LIFESTYLE GENOM
JI Lifestyle Genom.
PD JAN-DEC
PY 2024
VL 17
IS 1
BP 93
EP 101
DI 10.1159/000540337
PG 9
WC Genetics & Heredity; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Nutrition & Dietetics
GA O5D9J
UT WOS:001371341700001
PM 39047690
OA gold
DA 2025-06-11
ER

PT J
AU Das, M
   Sauceda, C
   Webster, NJG
AF Das, Manasi
   Sauceda, Consuelo
   Webster, Nicholas J. G.
TI Mitochondrial Dysfunction in Obesity and Reproduction
SO ENDOCRINOLOGY
LA English
DT Review
DE mitochondrial function; mitochondrial dynamics; lipid accumulation;
   oxidative stress; mitophagy; insulin resistance; ovarian dysfunction
ID INDUCED INSULIN-RESISTANCE; HUMAN SKELETAL-MUSCLE; PROTEIN-KINASE-C;
   FREE FATTY-ACID; PREMATURE OVARIAN FAILURE; OXYGEN SPECIES PRODUCTION;
   MATERNAL OBESITY; OXIDATIVE STRESS; METABOLIC SYNDROME; PERRAULT
   SYNDROME
AB Mounting evidence suggests a role for mitochondrial dysfunction in the pathogenesis of many diseases, including type 2 diabetes, aging, and ovarian failure. Because of the central role of mitochondria in energy production, heme biosynthesis, calcium buffering, steroidogenesis, and apoptosis signaling within cells, understanding the molecular mechanisms behind mitochondrial dysregulation and its potential implications in disease is critical. This review will take a journey through the past and summarize what is known about mitochondrial dysfunction in various disorders, focusing on metabolic alterations and reproductive abnormalities. Evidence is presented from studies in different human populations, and rodents with genetic manipulations of pathways known to affect mitochondrial function.
C1 [Das, Manasi; Sauceda, Consuelo; Webster, Nicholas J. G.] VA San Diego Healthcare Syst, San Diego, CA 92161 USA.
   [Das, Manasi; Sauceda, Consuelo; Webster, Nicholas J. G.] Univ Calif San Diego, Dept Med, Div Endocrinol & Metab, La Jolla, CA 92093 USA.
   [Webster, Nicholas J. G.] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92037 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA San Diego Healthcare System; University of California System;
   University of California San Diego; University of California System;
   University of California San Diego
RP Webster, NJG (corresponding author), Univ Calif San Diego, Dept Med, 9500 Gilman Dr, La Jolla, CA 92093 USA.
EM nwebster@ucsd.edu
RI Webster, Nick/AAI-8410-2021
OI Webster, Nicholas/0000-0002-3827-5750
FU VA Merit Review award [I01BX000130, I01BX004848]; Senior Research Career
   Scientist Award; National Institutes of Health [HD012303, CA196853,
   AI25860, HL141999]
FX This work was supported by a VA Merit Review award (I01BX000130 and
   I01BX004848), a Senior Research Career Scientist Award (to N.J.G.W.),
   and the National Institutes of Health (Grants Nos. HD012303, CA196853,
   AI25860, and HL141999 to N. J.G.W.)
CR Abbade J, 2020, BMJ OPEN DIAB RES CA, V8, DOI 10.1136/bmjdrc-2019-000923
   Abdulhasan MK, 2017, J ASSIST REPROD GEN, V34, P1595, DOI 10.1007/s10815-017-1027-y
   Allen JF, 1996, J THEOR BIOL, V180, P135, DOI 10.1006/jtbi.1996.0089
   Amiri M, 2020, MENOPAUSE, V27, P684, DOI 10.1097/GME.0000000000001513
   Anagnostis P, 2019, EUR J ENDOCRINOL, V180, P41, DOI 10.1530/EJE-18-0602
   Anderson EJ, 2009, J CLIN INVEST, V119, P573, DOI 10.1172/JCI37048
   Archer SL, 2013, NEW ENGL J MED, V369, P2236, DOI 10.1056/NEJMra1215233
   Asmann YW, 2006, DIABETES, V55, P3309, DOI 10.2337/db05-1230
   Bach D, 2003, J BIOL CHEM, V278, P17190, DOI 10.1074/jbc.M212754200
   Bajaj M, 2007, DIABETES, V56, P743, DOI 10.2337/db06-0840
   Barritt JA, 2001, HUM REPROD, V16, P513, DOI 10.1093/humrep/16.3.513
   Befroy DE, 2007, DIABETES, V56, P1376, DOI 10.2337/db06-0783
   Ben-Meir A, 2015, AGING CELL, V14, P887, DOI 10.1111/acel.12368
   Boney CM, 2005, PEDIATRICS, V115, pE290, DOI 10.1542/peds.2004-1808
   Boushel R, 2007, DIABETOLOGIA, V50, P790, DOI 10.1007/s00125-007-0594-3
   Bruce CR, 2012, DIABETES, V61, P3148, DOI 10.2337/db12-0029
   Cardenas-Perez RE, 2018, NUTR METAB, V15, DOI 10.1186/s12986-018-0279-6
   Cecchino GN, 2018, REPROD BIOMED ONLINE, V36, P686, DOI 10.1016/j.rbmo.2018.02.007
   Chen AL, 2018, HUM MOL GENET, V27, P1913, DOI 10.1093/hmg/ddy098
   Chen WQ, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0136421
   Cho J, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms14477
   Chung HK, 2017, J CELL BIOL, V216, P149, DOI 10.1083/jcb.201607110
   Cox L, 2014, INT J WOMENS HEALTH, V6, P235, DOI 10.2147/IJWH.S37636
   Cozzolino M, 2020, CURR OPIN OBSTET GYN, V32, P205, DOI 10.1097/GCO.0000000000000619
   Dallabona C, 2014, NEUROLOGY, V82, P2063, DOI 10.1212/WNL.0000000000000497
   de Wilde J, 2008, PHYSIOL GENOMICS, V32, P360, DOI 10.1152/physiolgenomics.00219.2007
   Demain LAM, 2017, CLIN GENET, V91, P199, DOI 10.1111/cge.12896
   Dincer Y, 2005, SCAND J CLIN LAB INV, V65, P721, DOI 10.1080/00365510500375263
   Dioguardi CC, 2016, MOL HUM REPROD, V22, P384, DOI 10.1093/molehr/gaw023
   Elshenawy S, 2016, MOL CELL ENDOCRINOL, V435, P2, DOI 10.1016/j.mce.2016.07.002
   Fox R, 2011, P NATL ACAD SCI USA, V108, P8779, DOI 10.1073/pnas.1106344108
   Fragouli E, 2015, PLOS GENET, V11, DOI 10.1371/journal.pgen.1005241
   Franks S, 2008, INT J OBESITY, V32, P1035, DOI 10.1038/ijo.2008.61
   Garcia-Roves P, 2007, P NATL ACAD SCI USA, V104, P10709, DOI 10.1073/pnas.0704024104
   Ghaddhab C, 2017, J PEDIATR-US, V184, P227, DOI 10.1016/j.jpeds.2017.02.008
   Gnaiger E, 2009, INT J BIOCHEM CELL B, V41, P1837, DOI 10.1016/j.biocel.2009.03.013
   Godfrey KM, 2017, LANCET DIABETES ENDO, V5, P53, DOI 10.1016/S2213-8587(16)30107-3
   Gonzalez-Franquesa A, 2017, ADV EXP MED BIOL, V982, P465, DOI 10.1007/978-3-319-55330-6_25
   Goodpaster BH, 2013, DIABETES, V62, P1032, DOI 10.2337/db12-1612
   Griffin ME, 1999, DIABETES, V48, P1270, DOI 10.2337/diabetes.48.6.1270
   Grindler NM, 2013, MOL HUM REPROD, V19, P486, DOI 10.1093/molehr/gat026
   Hamatani M, 2016, J HUM GENET, V61, P899, DOI 10.1038/jhg.2016.64
   Han DH, 2004, AM J PHYSIOL-ENDOC M, V286, pE347, DOI 10.1152/ajpendo.00434.2003
   Hancock CR, 2008, P NATL ACAD SCI USA, V105, P7815, DOI 10.1073/pnas.0802057105
   HARMAN D, 1956, J GERONTOL, V11, P298, DOI 10.1093/geronj/11.3.298
   He J, 2001, DIABETES, V50, P817, DOI 10.2337/diabetes.50.4.817
   Hevener AL, 2020, ENDOCRINOLOGY, V161, DOI 10.1210/endocr/bqz017
   Hoehn KL, 2009, P NATL ACAD SCI USA, V106, P17787, DOI 10.1073/pnas.0902380106
   Holloszy JO, 2009, AM J CLIN NUTR, V89, p463S, DOI 10.3945/ajcn.2008.26717C
   Holloway GP, 2007, AM J PHYSIOL-ENDOC M, V292, pE1782, DOI 10.1152/ajpendo.00639.2006
   Holmström MH, 2013, METABOLISM, V62, P1258, DOI 10.1016/j.metabol.2013.04.001
   Holmström MH, 2012, AM J PHYSIOL-ENDOC M, V302, pE731, DOI 10.1152/ajpendo.00159.2011
   Hulman A, 2017, DIABETOLOGIA, V60, P1252, DOI 10.1007/s00125-017-4275-6
   Hütter E, 2006, EXP GERONTOL, V41, P103, DOI 10.1016/j.exger.2005.09.011
   Igosheva N, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010074
   Iossa S, 2000, BRIT J NUTR, V84, P377
   Itani SI, 2002, DIABETES, V51, P2005, DOI 10.2337/diabetes.51.7.2005
   Jenkinson EM, 2013, AM J HUM GENET, V92, P605, DOI 10.1016/j.ajhg.2013.02.013
   Jovaisaite V, 2015, CURR OPIN CELL BIOL, V33, P74, DOI 10.1016/j.ceb.2014.12.003
   Kasapoglu I, 2020, ENDOCRINOLOGY, V161, DOI 10.1210/endocr/bqaa001
   Kelley DE, 1999, AM J PHYSIOL-ENDOC M, V277, pE1130
   Kelley DE, 2002, DIABETES, V51, P2944, DOI 10.2337/diabetes.51.10.2944
   Kim JA, 2008, CIRC RES, V102, P401, DOI 10.1161/CIRCRESAHA.107.165472
   Kim JY, 2000, AM J PHYSIOL-ENDOC M, V279, pE1039, DOI 10.1152/ajpendo.2000.279.5.E1039
   Koopman WJH, 2012, NEW ENGL J MED, V366, P1132, DOI 10.1056/NEJMra1012478
   Koves TR, 2005, J BIOL CHEM, V280, P33588, DOI 10.1074/jbc.M507621200
   Kujoth GC, 2005, SCIENCE, V309, P481, DOI 10.1126/science.1112125
   Labarta E, 2019, FERTIL STERIL, V111, P219, DOI 10.1016/j.fertnstert.2018.10.036
   Lai QH, 2018, FRONT MED-PRC, V12, P518, DOI 10.1007/s11684-017-0575-y
   Lambert AJ, 2009, METHODS MOL BIOL, V554, P165, DOI 10.1007/978-1-59745-521-3_11
   Lanzendorf SE, 1999, FERTIL STERIL, V71, P575, DOI 10.1016/S0015-0282(98)00504-4
   Larsson NG, 2010, ANNU REV BIOCHEM, V79, P683, DOI 10.1146/annurev-biochem-060408-093701
   Lee SH, 2011, METABOLISM, V60, P1677, DOI 10.1016/j.metabol.2011.04.010
   Lefort N, 2010, DIABETES, V59, P2444, DOI 10.2337/db10-0174
   Liu MY, 2013, HUM REPROD, V28, P707, DOI 10.1093/humrep/des437
   Lodi R, 2004, ANN NEUROL, V56, P719, DOI 10.1002/ana.20278
   Lokkegaard E, 2006, MATURITAS, V53, P226, DOI 10.1016/j.maturitas.2005.04.009
   Luoma P, 2004, LANCET, V364, P875, DOI 10.1016/S0140-6736(04)16983-3
   Mandy M, 2018, INT HEALTH, V10, P66, DOI 10.1093/inthealth/ihy006
   MARTIN BC, 1992, LANCET, V340, P925, DOI 10.1016/0140-6736(92)92814-V
   Mingrone G, 2005, DIABETOLOGIA, V48, P2108, DOI 10.1007/s00125-005-1918-9
   Mogensen M, 2007, DIABETES, V56, P1592, DOI 10.2337/db06-0981
   Mootha VK, 2004, P NATL ACAD SCI USA, V101, P6570, DOI 10.1073/pnas.0401401101
   Mootha VK, 2003, NAT GENET, V34, P267, DOI 10.1038/ng1180
   Morino H, 2014, NEUROLOGY, V83, P2054, DOI 10.1212/WNL.0000000000001036
   Morino K, 2005, J CLIN INVEST, V115, P3587, DOI 10.1172/JCI25151
   Morino K, 2006, DIABETES, V55, pS9, DOI 10.2337/db06-S002
   Morrow RM, 2017, P NATL ACAD SCI USA, V114, P2705, DOI 10.1073/pnas.1700997114
   Nair KS, 2008, DIABETES, V57, P1166, DOI 10.2337/db07-1556
   Nicolson GL, 2014, ALTERN THER HEALTH M, V20, P18
   Nunnari J, 2012, CELL, V148, P1145, DOI 10.1016/j.cell.2012.02.035
   Ou XH, 2012, HUM REPROD, V27, P2130, DOI 10.1093/humrep/des137
   Patti ME, 2003, P NATL ACAD SCI USA, V100, P8466, DOI 10.1073/pnas.1032913100
   Peigné M, 2014, ANN ENDOCRINOL-PARIS, V75, P194, DOI 10.1016/j.ando.2014.07.111
   Pereira RO, 2017, EMBO J, V36, P2126, DOI 10.15252/embj.201696179
   Petersen KF, 2004, NEW ENGL J MED, V350, P664, DOI 10.1056/NEJMoa031314
   Petersen KF, 2003, SCIENCE, V300, P1140, DOI 10.1126/science.1082889
   Petersen MC, 2017, TRENDS PHARMACOL SCI, V38, P649, DOI 10.1016/j.tips.2017.04.004
   Pfanner N, 2019, NAT REV MOL CELL BIO, V20, P267, DOI 10.1038/s41580-018-0092-0
   Phielix E, 2008, DIABETES, V57, P2943, DOI 10.2337/db08-0391
   Picard M, 2016, MITOCHONDRION, V30, P105, DOI 10.1016/j.mito.2016.07.003
   Pierce SB, 2013, AM J HUM GENET, V92, P614, DOI 10.1016/j.ajhg.2013.03.007
   Ploumi C, 2017, FEBS J, V284, P183, DOI 10.1111/febs.13820
   Plows JF, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19113342
   Podfigurna-Stopa A, 2016, J ENDOCRINOL INVEST, V39, P983, DOI 10.1007/s40618-016-0467-z
   Poulton J, 2002, REPRODUCTION, V123, P751, DOI 10.1530/rep.0.1230751
   Rahman S, 2019, NAT REV NEUROL, V15, P40, DOI 10.1038/s41582-018-0101-0
   REAVEN GM, 1988, DIABETES, V37, P1020, DOI 10.2337/diabetes.37.8.1020
   Ribas V, 2016, SCI TRANSL MED, V8, DOI 10.1126/scitranslmed.aad3815
   Ritov VB, 2005, DIABETES, V54, P8, DOI 10.2337/diabetes.54.1.8
   Rocha M, 2020, TRENDS ENDOCRIN MET, V31, P725, DOI 10.1016/j.tem.2020.03.004
   Rudich A, 1998, DIABETES, V47, P1562, DOI 10.2337/diabetes.47.10.1562
   Saben JL, 2016, CELL REP, V16, P1, DOI 10.1016/j.celrep.2016.05.065
   Saeed NAAAH, 2019, BMC RES NOTES, V12, DOI 10.1186/s13104-019-4453-3
   Samocha-Bonet D, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036320
   Samuel VT, 2007, J CLIN INVEST, V117, P739, DOI 10.1172/JCI30400
   Samuel VT, 2004, J BIOL CHEM, V279, P32345, DOI 10.1074/jbc.M313478200
   Sangwung P, 2020, ENDOCRINOLOGY, V161, DOI 10.1210/endocr/bqaa017
   Schmitz-Peiffer C, 1999, J BIOL CHEM, V274, P24202, DOI 10.1074/jbc.274.34.24202
   Seli E, 2016, CURR OPIN OBSTET GYN, V28, P158, DOI 10.1097/GCO.0000000000000274
   Sergi D, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00532
   Shamsi MB, 2013, MITOCHONDRION, V13, P96, DOI 10.1016/j.mito.2013.01.002
   Shulman GI, 2000, J CLIN INVEST, V106, P171, DOI 10.1172/JCI10583
   Simoneau JA, 1999, FASEB J, V13, P2051, DOI 10.1096/fasebj.13.14.2051
   Song C, 2016, SCI REP-UK, V6, DOI 10.1038/srep35165
   Sreekumar R, 2002, AM J PHYSIOL-ENDOC M, V282, pE1055, DOI 10.1152/ajpendo.00554.2001
   Stocco DM, 2001, ANNU REV PHYSIOL, V63, P193, DOI 10.1146/annurev.physiol.63.1.193
   Stump CS, 2003, P NATL ACAD SCI USA, V100, P7996, DOI 10.1073/pnas.1332551100
   Su ZQ, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.01193
   Sugiyama M, 2015, J REPROD DEVELOP, V61, P251, DOI 10.1262/jrd.2015-001
   Szendroedi J, 2007, PLOS MED, V4, P858, DOI 10.1371/journal.pmed.0040154
   Takeo S, 2014, J REPROD DEVELOP, V60, P92, DOI 10.1262/jrd.2013-102
   Tiosano D, 2019, ENDOCRINOLOGY, V160, P2353, DOI 10.1210/en.2019-00441
   Toledo FGS, 2008, DIABETES, V57, P987, DOI 10.2337/db07-1429
   Trenell MI, 2008, DIABETES CARE, V31, P1644, DOI 10.2337/dc08-0303
   Trifunovic A, 2004, NATURE, V429, P417, DOI 10.1038/nature02517
   Turner N, 2007, DIABETES, V56, P2085, DOI 10.2337/db07-0093
   Turner N, 2009, DIABETES, V58, P2547, DOI 10.2337/db09-0784
   Turrens JF, 2003, J PHYSIOL-LONDON, V552, P335, DOI 10.1113/jphysiol.2003.049478
   Udagawa O, 2014, CURR BIOL, V24, P2451, DOI 10.1016/j.cub.2014.08.060
   Vafai SB, 2012, NATURE, V491, P374, DOI 10.1038/nature11707
   Van Blerkom J, 2008, REPROD BIOMED ONLINE, V16, P553, DOI 10.1016/S1472-6483(10)60463-4
   Velde ERT, 2002, HUM REPROD UPDATE, V8, P141, DOI 10.1093/humupd/8.2.141
   Vermulst M, 2007, NAT GENET, V39, P540, DOI 10.1038/ng1988
   VONDRA K, 1977, DIABETOLOGIA, V13, P527, DOI 10.1007/BF01234508
   Wall CE, 2015, P NATL ACAD SCI USA, V112, P8714, DOI 10.1073/pnas.1509930112
   Wang CH, 2017, J BIOMED SCI, V24, DOI 10.1186/s12929-017-0375-3
   Wang CH, 2015, ANN NY ACAD SCI, V1350, P66, DOI 10.1111/nyas.12838
   Wang TR, 2018, AGING CELL, V17, DOI 10.1111/acel.12784
   Wang TR, 2017, AM J REPROD IMMUNOL, V77, DOI 10.1111/aji.12651
   Wang XW, 2015, NATURE, V524, P481, DOI 10.1038/nature14859
   Wredenberg A, 2006, BIOCHEM BIOPH RES CO, V350, P202, DOI 10.1016/j.bbrc.2006.09.029
   Youle RJ, 2011, NAT REV MOL CELL BIO, V12, P9, DOI 10.1038/nrm3028
   Yu CL, 2002, J BIOL CHEM, V277, P50230, DOI 10.1074/jbc.M200958200
   Zhang M, 2019, CELL DEATH DIS, V10, DOI 10.1038/s41419-019-1799-3
   Zhang T, 2019, J OVARIAN RES, V12, DOI 10.1186/s13048-019-0529-x
NR 156
TC 50
Z9 54
U1 2
U2 17
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD JAN
PY 2021
VL 162
IS 1
AR bqaa158
DI 10.1210/endocr/bqaa158
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA PQ4UF
UT WOS:000606540000006
PM 32945868
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Walsh, SW
AF Walsh, Scott W.
TI Obesity: a risk factor for preeclampsia
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID BODY-MASS-INDEX; NECROSIS-FACTOR-ALPHA; OXIDATIVE STRESS; WEIGHT-LOSS;
   ENDOTHELIAL DYSFUNCTION; INFLAMMATORY MARKERS; DENSITY-LIPOPROTEIN;
   METABOLIC SYNDROME; BLOOD-PRESSURE; WOMEN
AB Obesity is becoming an epidemic worldwide. Among young women, obesity is especially important because maternal obesity confers an increased risk of preeclampsia, a hypertensive disorder of pregnancy and a leading cause of maternal and fetal morbidity and mortality. It is not known why obesity is a risk factor for preeclampsia, but these conditions might be related through common features related to oxidative stress, inflammation and altered vascular function. Recently, extensive vascular infiltration of neutrophils and vascular inflammation has been reported in both preeclamptic women and obese women. Therefore, if the vasculature of obese women is inflamed, they could be at increased risk of developing preeclampsia when they become pregnant and are exposed to the additional burdens of pregnancy.
C1 [Walsh, Scott W.] Virginia Commonwealth Univ, Med Ctr, Dept Obstet & Gynecol, Richmond, VA 23298 USA.
   [Walsh, Scott W.] Virginia Commonwealth Univ, Med Ctr, Dept Physiol, Richmond, VA 23298 USA.
C3 Virginia Commonwealth University; Virginia Commonwealth University
RP Walsh, SW (corresponding author), Virginia Commonwealth Univ, Med Ctr, Dept Obstet & Gynecol, Med Coll Virginia Campus, Richmond, VA 23298 USA.
EM swwalsh@vcu.edu
FU NHLBI NIH HHS [R01 HL069851] Funding Source: Medline
CR Belogolovkin V, 2007, J MATERN-FETAL NEO M, V20, P509, DOI 10.1080/14767050701420027
   Bodnar LM, 2005, ANN EPIDEMIOL, V15, P475, DOI 10.1016/j.annepidem.2004.12.008
   Cadden KA, 2006, J SOC GYNECOL INVEST, V13, p228A
   Catov JM, 2007, INT J EPIDEMIOL, V36, P412, DOI 10.1093/ije/dyl271
   Cedergren MI, 2004, OBSTET GYNECOL, V103, P219, DOI 10.1097/01.AOG.0000107291.46159.00
   Chavarría ME, 2003, AM J OBSTET GYNECOL, V188, P986, DOI 10.1067/mob.2003.203
   Clément K, 2004, FASEB J, V18, P1657, DOI 10.1096/fj.04-2204com
   Couillard C, 2005, J CLIN ENDOCR METAB, V90, P6454, DOI 10.1210/jc.2004-2438
   Crofford LJ, 2000, ARTHRITIS RHEUM-US, V43, P4, DOI 10.1002/1529-0131(200001)43:1<4::AID-ANR2>3.0.CO;2-V
   Cunningham F. Gary, 2005, Williams Obstetrics
   Desideri G, 2005, J CLIN ENDOCR METAB, V90, P3145, DOI 10.1210/jc.2004-1741
   Doll S, 2002, INT J OBESITY, V26, P48, DOI 10.1038/sj.ijo.0801854
   Droyvold WB, 2005, INT J OBESITY, V29, P650, DOI 10.1038/sj.ijo.0802944
   Eiserich JP, 2002, SCIENCE, V296, P2391, DOI 10.1126/science.1106830
   Esposito K, 2002, J ENDOCRINOL INVEST, V25, P646, DOI 10.1007/BF03345092
   Esposito K, 2003, JAMA-J AM MED ASSOC, V289, P1799, DOI 10.1001/jama.289.14.1799
   Flegal KM, 2002, JAMA-J AM MED ASSOC, V288, P1723, DOI 10.1001/jama.288.14.1723
   Freeman DJ, 2004, HYPERTENSION, V44, P708, DOI 10.1161/01.HYP.0000143849.67254.ca
   Frostegård J, 2003, CLIN SCI, V105, P615, DOI 10.1042/CS20030152
   Germain AM, 2007, HYPERTENSION, V49, P90, DOI 10.1161/01.HYP.0000251522.18094.d4
   Gervasi MT, 2001, AM J OBSTET GYNECOL, V185, P792, DOI 10.1067/mob.2001.117311
   Girouard J, 2007, HYPERTENSION, V49, P1056, DOI 10.1161/HYPERTENSIONAHA.107.087528
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Irgens HU, 2001, BRIT MED J, V323, P1213, DOI 10.1136/bmj.323.7323.1213
   Kabiru W, 2004, AM J OBSTET GYNECOL, V191, P928, DOI 10.1016/j.ajog.2004.06.051
   Kauma S, 2002, OBSTET GYNECOL, V100, P706, DOI 10.1016/S0029-7844(02)02169-5
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Leik CE, 2004, HYPERTENSION, V44, P72, DOI 10.1161/01.HYP.0000130483.83154.37
   Lurie S, 1998, GYNECOL OBSTET INVES, V45, P229, DOI 10.1159/000009973
   Manten GTR, 2007, HYPERTENS PREGNANCY, V26, P39, DOI 10.1080/10641950601146574
   Mellembakken JR, 2002, HYPERTENSION, V39, P155, DOI 10.1161/hy0102.100778
   Mendez MA, 2005, AM J CLIN NUTR, V81, P714
   Mohn A, 2005, J CLIN ENDOCR METAB, V90, P2653, DOI 10.1210/jc.2004-2178
   Mokdad AH, 2003, JAMA-J AM MED ASSOC, V289, P76, DOI 10.1001/jama.289.1.76
   Nohr EA, 2005, OBSTET GYNECOL, V106, P250, DOI 10.1097/01.AOG.0000172422.81496.57
   O'Brien TE, 2003, EPIDEMIOLOGY, V14, P368, DOI 10.1097/00001648-200305000-00020
   Paradisi G, 2006, J CLIN ENDOCR METAB, V91, P1233, DOI 10.1210/jc.2005-1337
   Qiu CF, 2004, AM J HYPERTENS, V17, P154, DOI 10.1016/j.amjhyper.2003.09.011
   Ramos GA, 2005, AM J OBSTET GYNECOL, V193, P1089, DOI 10.1016/j.ajog.2005.06.040
   Ramsay JE, 2002, J CLIN ENDOCR METAB, V87, P4231, DOI 10.1210/jc.2002-020311
   Roberts JM, 2003, HYPERTENSION, V41, P437, DOI 10.1161/01.HYP.0000054981.03589.E9
   Rosenberg TJ, 2003, OBSTET GYNECOL, V102, P1022, DOI [10.1016/j.obstetgynecol.2003.07.005, 10.1016/S0029-7844(03)00878-0]
   Shah TJ, 2007, AM J OBSTET GYNECOL, V196, P48, DOI 10.1016/j.ajog.2006.08.038
   Shah TJ, 2006, J SOC GYNECOL INVEST, V13, p291A
   Shah TJ, 2006, J SOC GYNECOL INVEST, V13, p194A
   Smith GCS, 2001, LANCET, V357, P2002, DOI 10.1016/S0140-6736(00)05112-6
   Spaanderman MEA, 2006, AM J OBSTET GYNECOL, V194, P855, DOI 10.1016/j.ajog.2005.09.012
   Srinivasan SR, 2006, HYPERTENSION, V48, P33, DOI 10.1161/01.HYP.0000226410.11198.f4
   Stewart FM, 2007, J CLIN ENDOCR METAB, V92, P969, DOI 10.1210/jc.2006-2083
   STONE JL, 1994, OBSTET GYNECOL, V83, P357
   Straczkowski M, 2002, J CLIN ENDOCR METAB, V87, P4602, DOI 10.1210/jc.2002-020135
   Surkan PJ, 2004, OBSTET GYNECOL, V104, P720, DOI 10.1097/01.AOG.0000141442.59573.cd
   Thomas F, 2005, HYPERTENSION, V46, P654, DOI 10.1161/01.HYP.0000184282.51550.00
   Touyz RM, 2004, HISTOCHEM CELL BIOL, V122, P339, DOI 10.1007/s00418-004-0696-7
   Touyz RM, 2004, HYPERTENSION, V44, P248, DOI 10.1161/01.HYP.0000138070.47616.9d
   Urakawa H, 2003, J CLIN ENDOCR METAB, V88, P4673, DOI 10.1210/jc.2003-030202
   van Nieuwenhoven ALV, 2002, FERTIL STERIL, V77, P1032, DOI 10.1016/S0015-0282(02)02976-X
   Vaughan JE, 2005, AM J OBSTET GYNECOL, V193, P830, DOI 10.1016/j.ajog.2005.01.057
   Vaughan JE, 2006, AM J OBSTET GYNECOL, V195, P1415, DOI 10.1016/j.ajog.2006.02.053
   Villamor E, 2006, LANCET, V368, P1164, DOI 10.1016/S0140-6736(06)69473-7
   Walsh SW, 2000, FASEB J, V14, P1289, DOI 10.1096/fj.14.10.1289
   Walsh SW, 2004, PROSTAG LEUKOTR ESS, V70, P223, DOI 10.1016/j.plefa.2003.04.010
   Weinbrenner T, 2006, AM J CLIN NUTR, V83, P30
   Weiss JL, 2004, AM J OBSTET GYNECOL, V190, P1091, DOI 10.1016/j.ajog.2003.09.058
   White WB, 2007, HYPERTENSION, V49, P408, DOI 10.1161/01.HYP.0000258106.74139.25
   WHO Consultation, 2000, WHO TECH REP SER, V894, P1
   Zhou LC, 2006, FREE RADICAL BIO MED, V41, P1384, DOI 10.1016/j.freeradbiomed.2006.07.019
   Ziccardi P, 2002, CIRCULATION, V105, P804, DOI 10.1161/hc0702.104279
NR 68
TC 118
Z9 132
U1 0
U2 6
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD DEC
PY 2007
VL 18
IS 10
BP 365
EP 370
DI 10.1016/j.tem.2007.09.003
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 242PO
UT WOS:000251738000001
PM 18023357
DA 2025-06-11
ER

PT J
AU Porras, D
   Nistal, E
   Martínez-Flórez, S
   Pisonero-Vaquero, S
   Olcoz, JL
   Jover, R
   González-Gallego, J
   García-Mediavilla, MV
   Sánchez-Campos, S
AF Porras, David
   Nistal, Esther
   Martinez-Florez, Susana
   Pisonero-Vaquero, Sandra
   Luis Olcoz, Jose
   Jover, Ramiro
   Gonzalez-Gallego, Javier
   Victoria Garcia-Mediavilla, Maria
   Sanchez-Campos, Sonia
TI Protective effect of quercetin on high-fat diet-induced non-alcoholic
   fatty liver disease in mice is mediated by modulating intestinal
   microbiota imbalance and related gut-liver axis activation
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE CYP2E1; Dysbiosis; Endoplasmic reticulum stress; Gut-liver axis;
   Inflammasome; Inflammation; Intestinal barrier function; Intestinal
   microbiota; Lipid metabolism; Lipotoxicity; NAFLD; Quercetin
ID HELICOBACTER-PYLORI INFECTION; ENDOPLASMIC-RETICULUM STRESS;
   CYTOCHROME-P450 2E1 CYP2E1; TOLL-LIKE RECEPTORS; OXIDATIVE STRESS;
   LIPID-ACCUMULATION; INSULIN-RESISTANCE; DOWN-REGULATION; CROSS-TALK;
   ER-STRESS
AB Gut microbiota is involved in obesity, metabolic syndrome and the progression of nonalcoholic fatty liver disease (NAFLD). It has been recently suggested that the flavonoid quercetin may have the ability to modulate the intestinal microbiota composition, suggesting a prebiotic capacity which highlights a great therapeutic potential in NAFLD. The present study aims to investigate benefits of experimental treatment with quercetin on gut microbial balance and related gut-liver axis activation in a nutritional animal model of NAFLD associated to obesity. C57BL/6J mice were challenged with high fat diet (HFD) supplemented or not with quercetin for 16 weeks. HFD induced obesity, metabolic syndrome and the development of hepatic steatosis as main hepatic histological finding. Increased accumulation of intrahepatic lipids was associated with altered gene expression related to lipid metabolism, as a result of deregulation of their major modulators. Quercetin supplementation decreased insulin resistance and NAFLD activity score, by reducing the intrahepatic lipid accumulation through its ability to modulate lipid metabolism gene expression, cytochrome P450 2E1 (CYP2E1)-dependent lipoperoxidation and related lipotoxicity. Microbiota composition was determined via 16S ribosomal RNA Illumina next-generation sequencing. Metagenomic studies revealed HFD-dependent differences at phylum, class and genus levels leading to dysbiosis, characterized by an increase in Firmicutes/Bacteroidetes ratio and in Gram-negative bacteria, and a dramatically increased detection of Helicobacter genus. Dysbiosis was accompanied by endotoxemia, intestinal barrier dysfunction and gut-liver axis alteration and subsequent inflammatory gene overexpression. Dysbiosis-mediated toll-like receptor 4 (TLR-4)-NF-kappa B signaling pathway activation was associated with inflammasome initiation response and reticulum stress pathway induction. Quercetin reverted gut microbiota imbalance and related endotoxemia-mediated TLR-4 pathway induction, with subsequent inhibition of inflammasome response and reticulum stress pathway activation, leading to the blockage of lipid metabolism gene expression deregulation. Our results support the suitability of quercetin as a therapeutic approach for obesity-associated NAFLD via its anti-inflammatory, antioxidant and prebiotic integrative response.
C1 [Porras, David; Nistal, Esther; Martinez-Florez, Susana; Pisonero-Vaquero, Sandra; Gonzalez-Gallego, Javier; Victoria Garcia-Mediavilla, Maria; Sanchez-Campos, Sonia] Univ Leon, Inst Biomed IBIOMED, Leon, Spain.
   [Luis Olcoz, Jose; Jover, Ramiro; Gonzalez-Gallego, Javier; Victoria Garcia-Mediavilla, Maria; Sanchez-Campos, Sonia] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain.
   [Luis Olcoz, Jose] Complejo Asistencial Univ Leon, Dept Gastroenterol, Leon, Spain.
   [Jover, Ramiro] IIS Hosp La Fe, Expt Hepatol Unit, Valencia, Spain.
   [Jover, Ramiro] Univ Valencia, Dept Biochem & Mol Biol, Valencia, Spain.
C3 Universidad de Leon; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEREHD; Universidad de Leon;
   University of Valencia
RP Sánchez-Campos, S (corresponding author), Univ Leon, Inst Biomed, Campus Vegazana, E-24071 Leon, Spain.
EM dporrs00@estudiantes.unileon.es; esthernistal@hotmail.com;
   smarf@unileon.es; spisv@unileon.es; jolcozg@gmail.com;
   ramiro.jover@uv.es; jgonga@unileon.es; mvgarm@unileon.es;
   ssanc@unileon.es
RI Porras, David/ABH-7475-2020; Gonzalez-Gallego, Javier/D-8219-2012;
   Nistal, Esther/ABL-5651-2022; Martínez Flórez, Susana/LKM-2602-2024;
   Garcia-Mediavilla, Victoria/F-9641-2015; Sanchez-Campos,
   Sonia/F-9654-2015; JOVER, RAMIRO/O-9796-2017
OI Martinez, Susana/0000-0002-7200-8744; Garcia-Mediavilla,
   Victoria/0000-0002-5722-7500; Porras, David/0000-0002-8824-7504;
   Sanchez-Campos, Sonia/0000-0003-2672-734X; Gonzalez-Gallego,
   Javier/0000-0002-4386-9342; Nistal, Esther/0000-0002-2201-5575; JOVER,
   RAMIRO/0000-0002-4914-5804
FU Ministerio de Economia y Competitividad/FEDER [BFU2013-48141-R]; Junta
   de Castilla y Leon [LE135U13, GRS1428/A/16, BIO/LE02/15]; Junta de
   Castilla y Leon y Fondo Europeo de Desarrollo Regional (FEDER)
   [LE063U16]; Fondo de Investigacion Sanitaria (FIS); Instituto de Salud
   Carlos III [ISCIII-FEDER PI 13/01470]; CIBERehd; Instituto de Salud
   Carlos III, Spain
FX This work was supported by grants to Javier Gonzalez-Gallego and Sonia
   Sanchez Campos from Ministerio de Economia y Competitividad/FEDER
   (BFU2013-48141-R) and Junta de Castilla y Leon (LE135U13, GRS1428/A/16
   and BIO/LE02/15), LE063U16 (Junta de Castilla y Leon y Fondo Europeo de
   Desarrollo Regional (FEDER)) and Ramiro Jover from Fondo de
   Investigacion Sanitaria (FIS), Instituto de Salud Carlos III
   (ISCIII-FEDER PI 13/01470). Maria V. Garcia-Mediavilla was supported by
   CIBERehd contracts. CIBERehd is funded by the Instituto de Salud Carlos
   III, Spain.
CR Abdelmegeed MA, 2012, J HEPATOL, V57, P860, DOI 10.1016/j.jhep.2012.05.019
   Abu-Shanab A, 2010, NAT REV GASTRO HEPAT, V7, P691, DOI 10.1038/nrgastro.2010.172
   Aron-Wisnewsky J, 2013, CLIN MICROBIOL INFEC, V19, P338, DOI 10.1111/1469-0691.12140
   Baeg MK, 2016, WORLD J GASTROENTERO, V22, P2592, DOI 10.3748/wjg.v22.i8.2592
   Bieghs Veerle, 2014, Hepatobiliary Surg Nutr, V3, P377, DOI 10.3978/j.issn.2304-3881.2014.12.04
   Boursier J, 2016, HEPATOLOGY, V63, P764, DOI 10.1002/hep.28356
   Buzzetti E, 2016, METABOLISM, V65, P1038, DOI 10.1016/j.metabol.2015.12.012
   Byun EB, 2013, BIOCHEM BIOPH RES CO, V431, P698, DOI 10.1016/j.bbrc.2013.01.056
   Cai DS, 2005, NAT MED, V11, P183, DOI 10.1038/nm1166
   Calabrese V, 2015, MOL IMMUNOL, V63, P153, DOI 10.1016/j.molimm.2014.05.011
   Cardona F, 2013, J NUTR BIOCHEM, V24, P1415, DOI 10.1016/j.jnutbio.2013.05.001
   Carotti Simone, 2015, World J Gastrointest Pathophysiol, V6, P99, DOI 10.4291/wjgp.v6.i4.99
   Chao J, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0096969
   Csak T, 2011, HEPATOLOGY, V54, P133, DOI 10.1002/hep.24341
   Dandekar A, 2015, METHODS MOL BIOL, V1292, P205, DOI 10.1007/978-1-4939-2522-3_15
   DeMinicis S, 2014, HEPATOLOGY, V59, P1738, DOI 10.1002/hep.26695
   Dong J, 2014, J LIPID RES, V55, P363, DOI 10.1194/jlr.M038786
   Duda-Chodak A, 2015, EUR J NUTR, V54, P325, DOI 10.1007/s00394-015-0852-y
   Estadella D, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/137579
   Eteberria U, 2015, J NUTR BIOCHEM, V26, P651, DOI 10.1016/j.jnutbio.2015.01.002
   Miquilena-Colina ME, 2011, GUT, V60, P1394, DOI 10.1136/gut.2010.222844
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Farrell GC, 2012, GUT LIVER, V6, P149, DOI 10.5009/gnl.2012.6.2.149
   Ganz M, 2013, HEPATOL INT, V7, pS771, DOI 10.1007/s12072-013-9468-6
   Ganz M, 2014, WORLD J GASTROENTERO, V20, P8525, DOI 10.3748/wjg.v20.i26.8525
   Gkolfakis P, 2015, HEPATOB PANCREAT DIS, V14, P572, DOI 10.1016/S1499-3872(15)60026-1
   González-Rodríguez A, 2014, CELL DEATH DIS, V5, DOI 10.1038/cddis.2014.162
   González-Segovia R, 2008, J GASTROENTEROL, V43, P441, DOI 10.1007/s00535-008-2184-7
   Guzmán C, 2013, BBA-MOL CELL BIOL L, V1831, P803, DOI 10.1016/j.bbalip.2012.12.014
   Henao-Mejia J, 2012, NATURE, V482, P179, DOI 10.1038/nature10809
   Herlemann DPR, 2011, ISME J, V5, P1571, DOI 10.1038/ismej.2011.41
   Imajo K, 2014, SEMIN IMMUNOPATHOL, V36, P115, DOI 10.1007/s00281-013-0404-6
   Jamali R, 2013, HEPAT MON, V13, DOI 10.5812/hepatmon.14679
   Jung CH, 2013, PHYTOTHER RES, V27, P139, DOI 10.1002/ptr.4687
   Kawabata K, 2013, BIOFACTORS, V39, P422, DOI 10.1002/biof.1081
   Kim HR, 2009, J CELL SCI, V122, P1126, DOI 10.1242/jcs.038430
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Lambert JE, 2015, BMC GASTROENTEROL, V15, DOI 10.1186/s12876-015-0400-5
   Lau E, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/979515
   Le Roy T, 2013, GUT, V62, P1787, DOI 10.1136/gutjnl-2012-303816
   Lee JY, 2003, J LIPID RES, V44, P479, DOI 10.1194/jlr.M200361-JLR200
   Lewis MD, 2005, ARCH BIOCHEM BIOPHYS, V436, P237, DOI 10.1016/j.abb.2005.02.010
   Lima-Cabello E, 2011, CLIN SCI, V120, P239, DOI 10.1042/CS20100387
   Liu CM, 2013, FREE RADICAL RES, V47, P192, DOI 10.3109/10715762.2012.760198
   Machado M, 2006, CURR OPIN CLIN NUTR, V9, P637, DOI 10.1097/01.mco.0000241677.40170.17
   Malhi H, 2011, J HEPATOL, V54, P795, DOI 10.1016/j.jhep.2010.11.005
   Marcolin E, 2012, J NUTR, V142, P1821, DOI 10.3945/jn.112.165274
   Mei L, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0138078
   Memon RA, 1999, BBA-MOL CELL BIOL L, V1440, P118, DOI 10.1016/S1388-1981(99)00120-1
   Miura K, 2014, WORLD J GASTROENTERO, V20, P7381, DOI 10.3748/wjg.v20.i23.7381
   Monika P, 2015, PHYTOMEDICINE, V22, P939, DOI 10.1016/j.phymed.2015.07.001
   Musso G, 2013, PROG LIPID RES, V52, P175, DOI 10.1016/j.plipres.2012.11.002
   Neuschwander-Tetri BA, 2010, HEPATOLOGY, V52, P774, DOI 10.1002/hep.23719
   Nishikawa S, 2007, EXP ANIM TOKYO, V56, P263, DOI 10.1538/expanim.56.263
   Oksanen JB., vegan: Community Ecology Package, V2, ped2018
   Okushin K, 2015, BMC GASTROENTEROL, V15, DOI 10.1186/s12876-015-0247-9
   Pisonero-Vaquero S, 2015, MOL NUTR FOOD RES, V59, P879, DOI 10.1002/mnfr.201400913
   Polyzos SA, 2013, METABOLISM, V62, P121, DOI 10.1016/j.metabol.2012.06.007
   Rahman K., 2016, LAB INVESTIG
   Rocha DM, 2016, ATHEROSCLEROSIS, V244, P211, DOI 10.1016/j.atherosclerosis.2015.11.015
   Sawada K, 2014, HEPATOL RES, V44, P920, DOI 10.1111/hepr.12199
   Serino M, 2012, GUT, V61, P543, DOI 10.1136/gutjnl-2011-301012
   Sharifnia T, 2015, AM J PHYSIOL-GASTR L, V309, pG270, DOI 10.1152/ajpgi.00304.2014
   Song H., 2015, J GASTROENTEROL HEPA
   Sumida Y, 2015, J GASTROENTEROL, V50, P996, DOI 10.1007/s00535-015-1039-2
   Surapaneni KM, 2014, EUR REV MED PHARMACO, V18, P2736
   Surapaneni KM, 2014, PHARMACOGN RES, V6, P153, DOI 10.4103/0974-8490.129037
   Suzuki T, 2013, CELL MOL LIFE SCI, V70, P631, DOI 10.1007/s00018-012-1070-x
   Szabo G, 2015, NAT REV GASTRO HEPAT, V12, P387, DOI 10.1038/nrgastro.2015.94
   Szabo G, 2012, J HEPATOL, V57, P642, DOI 10.1016/j.jhep.2012.03.035
   Takaki A, 2013, INT J MOL SCI, V14, P20704, DOI 10.3390/ijms141020704
   Tiari Y., 2016, BIOMED RES INT, V2016
   Tieppo J, 2009, J NUTR, V139, P1339, DOI 10.3945/jn.109.105353
   Tiniakos DG, 2010, ANNU REV PATHOL-MECH, V5, P145, DOI 10.1146/annurev-pathol-121808-102132
   Tobar N, 2011, ENDOCRINOLOGY, V152, P4080, DOI 10.1210/en.2011-0249
   Usami M, 2015, WORLD J GASTROENTERO, V21, P11597, DOI 10.3748/wjg.v21.i41.11597
   Vernon G, 2011, ALIMENT PHARM THER, V34, P274, DOI 10.1111/j.1365-2036.2011.04724.x
   Vidyashankar S, 2013, TOXICOL IN VITRO, V27, P945, DOI 10.1016/j.tiv.2013.01.014
   Waluga M, 2015, WORLD J HEPATOL, V7, P2136, DOI 10.4254/wjh.v7.i18.2136
   Wang LL, 2016, HEPATOL RES, V46, P225, DOI 10.1111/hepr.12557
   Wang W, 2013, BRIT J PHARMACOL, V169, P1352, DOI 10.1111/bph.12226
   Wang YC, 2014, WORLD J GASTROENTERO, V20, P10368, DOI 10.3748/wjg.v20.i30.10368
   Whelan K, 2009, AM J CLIN NUTR, V89, P240, DOI 10.3945/ajcn.2008.26219
   Wood Natalie J, 2012, Nat Rev Gastroenterol Hepatol, V9, P123, DOI 10.1038/nrgastro.2012.21
   Zhang Chaoxian, 2016, Zhong Nan Da Xue Xue Bao Yi Xue Ban, V41, P359, DOI 10.11817/j.issn.1672-7347.2016.04.004
   Zhang X, 2015, ANTIOXID REDOX SIGN, V22, P848, DOI 10.1089/ars.2014.5868
NR 86
TC 397
Z9 424
U1 15
U2 317
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD JAN
PY 2017
VL 102
BP 188
EP 202
DI 10.1016/j.freeradbiomed.2016.11.037
PG 15
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA EI3AG
UT WOS:000392361200016
PM 27890642
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Soltani, H
   Keim, NL
   Laugero, KD
AF Soltani, Hoda
   Keim, Nancy L.
   Laugero, Kevin D.
TI Waking Salivary Cortisol Associated with Magnitude of Cholesterol
   Reduction in Women Fed a Healthy Whole-Food Diet for 8 Weeks
SO CURRENT DEVELOPMENTS IN NUTRITION
LA English
DT Article
DE whole food diet intervention; cholesterol response; awakening cortisol
   phenotype; randomized control trial; women
ID STRESS; GLUCOCORTICOIDS; INSULIN; CARBOHYDRATE; METABOLISM; DISEASE;
   RISK; FAT
AB Background: Diet and cortisol are independently linked to cardiometabolic function and health, but underlying alterations in circulating cortisol may influence beneficial cardiometabolic effects of consuming a healthy diet.
   Objective: This study was a secondary analysis to examine whether baseline concentrations of waking salivary cortisol interacted with 8-wk whole-food diet interventions to affect cardiometabolic outcomes.
   Methods: A randomized, double-blind, controlled 8-wk diet intervention was conducted in 44 participants. The trial was conducted at the Western Human Nutrition Research Center in Davis, California. Participants were overweight or obese women aged 20-64 y, minimally active, and insulin resistant and/or dyslipidemic. Diets were randomly assigned and based on the 2010 Dietary Guidelines for Americans (DGA) or a typical American diet (TAD). Cardiometabolic risk factors and salivary cortisol were assessed at baseline and at 8 wk. Primary outcome measures included 8-wk change in overnight fasted cardiometabolic risk factors, including blood pressure, BMI, and circulating triglycerides, cholesterol, glycated hemoglobin (HbA1c), nonesterified fatty acids, and high-sensitivity C-reactive protein. This trial was approved by the University of California, Davis, Institutional Review Board.
   Results: Baseline waking cortisol concentrations interacted (P = 0.0474) with diet to affect 8-wk changes in fasting total cholesterol. Compared with a TAD, a DGA diet was associated with 8-wk decreases in total cholesterol in participants with low (10th percentile of all participants; 2.76 nmol/L) or average (7.76 nmol/L) but not higher (90th percentile of all participants; 13.44 nmol/L) baseline waking cortisol. Consistent with this finding, there was a DGA-specific positive association (P = 0.0047; b: 2.88 +/- 0.94) between baseline waking cortisol and 8-wk increases in total cholesterol.
   Conclusions: The underlying status of waking cortisol may explain interindividual variability in total cholesterol responses to whole-food diets.
C1 [Soltani, Hoda; Keim, Nancy L.; Laugero, Kevin D.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Keim, Nancy L.; Laugero, Kevin D.] ARS, Obes & Metab Res Unit, USDA, Western Human Nutr Res Ctr, Davis, CA 95616 USA.
C3 University of California System; University of California Davis; United
   States Department of Agriculture (USDA)
RP Laugero, KD (corresponding author), Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.; Laugero, KD (corresponding author), ARS, Obes & Metab Res Unit, USDA, Western Human Nutr Res Ctr, Davis, CA 95616 USA.
EM kevin.laugero@usda.gov
OI Keim, Nancy/0000-0002-6601-7572
FU USDA Agricultural Research Service project [2032-51530-022-00-D];
   National Dairy Council; Campbell Soup Company
FX Supported by funding from USDA Agricultural Research Service project
   2032-51530-022-00-D, the National Dairy Council, and the Campbell Soup
   Company.
CR Anagnostis P, 2009, J CLIN ENDOCR METAB, V94, P2692, DOI 10.1210/jc.2009-0370
   Arnaldi G, 2010, NEUROENDOCRINOLOGY, V92, P86, DOI 10.1159/000314213
   Aschbacher K, 2014, PSYCHONEUROENDOCRINO, V46, P14, DOI 10.1016/j.psyneuen.2014.04.003
   Bujtor M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020356
   Christiansen JJ, 2007, J CLIN ENDOCR METAB, V92, P3553, DOI 10.1210/jc.2007-0445
   Crawford AA, 2019, EUR J ENDOCRINOL, V181, P429, DOI 10.1530/EJE-19-0161
   DALLMAN MF, 1993, FRONT NEUROENDOCRIN, V14, P303, DOI 10.1006/frne.1993.1010
   Dallman MF, 1995, ANN NY ACAD SCI, V771, P730, DOI 10.1111/j.1749-6632.1995.tb44724.x
   Danese A, 2009, ARCH PEDIAT ADOL MED, V163, P1135, DOI 10.1001/archpediatrics.2009.214
   DiNicolantonio JJ, 2016, PROG CARDIOVASC DIS, V58, P464, DOI 10.1016/j.pcad.2015.11.006
   DINNEEN S, 1993, J CLIN INVEST, V92, P2283, DOI 10.1172/JCI116832
   Epel E, 2004, ANN NY ACAD SCI, V1032, P208, DOI 10.1196/annals.1314.022
   ETTINGER WH, 1987, ATHEROSCLEROSIS, V63, P167, DOI 10.1016/0021-9150(87)90117-1
   Gregg R., 1993, Hormones in Lipoprotein Metabolism, P169
   Hazra A, 2008, PHARM RES-DORDR, V25, P769, DOI 10.1007/s11095-007-9371-8
   KIRSCHBAUM C, 1993, NEUROPSYCHOBIOLOGY, V28, P76, DOI 10.1159/000119004
   Krishnan S, 2018, AM J CLIN NUTR, V108, P266, DOI 10.1093/ajcn/nqy113
   Lee JY, 2001, J BIOL CHEM, V276, P16683, DOI 10.1074/jbc.M011695200
   Prodam F, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-44
   RIZZA RA, 1982, J CLIN ENDOCR METAB, V54, P131, DOI 10.1210/jcem-54-1-131
   Robinson G, 2022, J CLIN INVEST, V132, DOI 10.1172/JCI148552
   Rosmond R, 2005, PSYCHONEUROENDOCRINO, V30, P1, DOI 10.1016/j.psyneuen.2004.05.007
   Schäcke H, 2002, PHARMACOL THERAPEUT, V96, P23, DOI 10.1016/S0163-7258(02)00297-8
   SCHWERTNER HA, 1984, ARTERIOSCLEROSIS, V4, P59, DOI 10.1161/01.ATV.4.1.59
   Soltani H, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112563
   Soltani H, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111606
   van Raalte DH, 2009, EUR J CLIN INVEST, V39, P81, DOI 10.1111/j.1365-2362.2008.02067.x
   Walker BR, 2007, EUR J ENDOCRINOL, V157, P545, DOI 10.1530/EJE-07-0455
   Witbracht MG, 2013, J NUTR, V143, P46, DOI 10.3945/jn.112.166355
NR 29
TC 0
Z9 0
U1 2
U2 4
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 2475-2991
J9 CURR DEV NUTR
JI Curr. Dev. Nutr.
PD MAY 28
PY 2022
VL 6
IS 5
AR nzac083
DI 10.1093/cdn/nzac083
PG 8
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA 1T0EI
UT WOS:000804412900001
PM 35669046
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Lai, WJ
   Shi, M
   Huang, RS
   Fu, P
   Ma, L
AF Lai, Weijing
   Shi, Min
   Huang, Rongshuang
   Fu, Ping
   Ma, Liang
TI Fatty acid-binding protein 4 in kidney diseases: From mechanisms to
   clinics
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Kidney diseases; FABP4; Biomarker; Therapeutic target
ID ENDOPLASMIC-RETICULUM STRESS; METABOLIC SYNDROME; GAMMA ACTIVITY;
   ADIPOCYTE; INHIBITORS; LEVEL; CELLS; DRUG; IDENTIFICATION; CALCIFICATION
AB Considerable evidence indicated the relationship between fatty acid-binding protein 4 (FABP4) and kidney diseases. FABP4, a small molecular lipid chaperone, is identified to regulate fatty acid oxidation, inflammation, apoptosis, endoplasmic reticulum stress and macrophage-to-myofibroblast transition in kidney diseases. Many studies have shown that circulating FABP4 level is related to proteinuria, renal function decline, cardiovascular complications of end-stage renal disease and even the prognosis of kidney transplanted patients. Notably, pharmacological or genetic inhibition of FABP4 attenuated renal injury in the various experimental models of kidney diseases, making it promising to develop potential therapeutic strategies targeting FABP4 in kidney diseases. In this study, we updated and reviewed the mechanisms and clinical significance of FABP4 in kidney diseases.
C1 [Lai, Weijing; Shi, Min; Huang, Rongshuang; Fu, Ping; Ma, Liang] Sichuan Univ, West China Hosp, Kidney Res Inst, Dept Nephrol, Chengdu 610041, Sichuan, Peoples R China.
   [Lai, Weijing] Chengdu Med Coll, Affiliated Hosp 1, Clin Med Coll, Dept Nephrol, Chengdu 610500, Peoples R China.
   [Fu, Ping; Ma, Liang] Sichuan Univ, West China Hosp, Kidney Res Inst, Dept Nephrol, Guoxue Alley 37, Chengdu 610041, Peoples R China.
C3 Sichuan University; Chengdu Medical College; Sichuan University
RP Fu, P; Ma, L (corresponding author), Sichuan Univ, West China Hosp, Kidney Res Inst, Dept Nephrol, Guoxue Alley 37, Chengdu 610041, Peoples R China.
EM fupinghx@scu.edu.cn; liang_m@scu.edu.cn
RI Ma, Liang/AGS-5714-2022
OI Ma, Liang/0000-0001-8327-7969
FU National Key R & D Program of China [2020YFC2005000]; Science/Technology
   Project of Sichuan Province [2021YFQ0027]
FX Funding This study was supported by the National Key R & D Program of
   China (2020YFC2005000) and the Science/Technology Project of Sichuan
   Province (2021YFQ0027) .
CR Abebe A, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-94946-3
   Adachi Y, 2012, HISTOCHEM CELL BIOL, V138, P397, DOI 10.1007/s00418-012-0963-y
   Barf T, 2009, BIOORG MED CHEM LETT, V19, P1745, DOI 10.1016/j.bmcl.2009.01.084
   BERNLOHR DA, 1985, BIOCHEM BIOPH RES CO, V132, P850, DOI 10.1016/0006-291X(85)91209-4
   Boss M, 2015, ATHEROSCLEROSIS, V240, P424, DOI 10.1016/j.atherosclerosis.2015.03.042
   Cabré A, 2008, CLIN CHEM, V54, P181, DOI 10.1373/clinchem.2007.094672
   Cai HY, 2013, ACTA PHARMACOL SIN, V34, P1397, DOI 10.1038/aps.2013.97
   Cai HY, 2015, EUR J MED CHEM, V90, P241, DOI 10.1016/j.ejmech.2014.11.020
   Cao ZM, 2011, J DIABETES INVEST, V2, P243, DOI 10.1111/j.2040-1124.2011.00131.x
   Charlton A, 2021, BIOLOGY-BASEL, V10, DOI 10.3390/biology10010018
   Chen JZ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0099862
   Chen TL, 2019, METABOLITES, V9, DOI 10.3390/metabo9080159
   Chen YC, 2018, CLIN EXP NEPHROL, V22, P188, DOI 10.1007/s10157-017-1438-1
   Chen YT, 2021, CELL DEATH DIS, V12, DOI 10.1038/s41419-021-03850-1
   Chuang TF, 2020, BMC NEPHROL, V21, DOI 10.1186/s12882-020-01950-2
   Dai JG, 2021, ANIM SCI J, V92, DOI 10.1111/asj.13582
   Duffy CM, 2017, MOL CELL NEUROSCI, V80, P52, DOI 10.1016/j.mcn.2017.02.004
   Ebert T, 2014, NUTR METAB CARDIOVAS, V24, P1027, DOI 10.1016/j.numecd.2014.03.006
   Eknoyan G, 2002, AM J KIDNEY DIS, V39, pS14, DOI 10.1053/ajkd.2002.30939
   Elmasri H, 2012, ANGIOGENESIS, V15, P457, DOI 10.1007/s10456-012-9274-0
   Elmasri H, 2009, FASEB J, V23, P3865, DOI 10.1096/fj.09-134882
   Fan HJ, 2022, LIFE-BASEL, V12, DOI 10.3390/life12020316
   Feng YH, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.566535
   Figueroa JD, 2016, J NEUROTRAUM, V33, P1436, DOI 10.1089/neu.2015.4186
   Floresta G, 2022, EUR J MED CHEM, V240, DOI 10.1016/j.ejmech.2022.114604
   Floresta G, 2019, BIOORG CHEM, V84, P276, DOI 10.1016/j.bioorg.2018.11.045
   Floresta G, 2017, EUR J MED CHEM, V138, P854, DOI 10.1016/j.ejmech.2017.07.022
   Furuhashi M, 2008, NAT REV DRUG DISCOV, V7, P489, DOI 10.1038/nrd2589
   Furuhashi M, 2016, ARTERIOSCL THROM VAS, V36, P825, DOI 10.1161/ATVBAHA.116.307225
   Furuhashi M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027356
   Fuseya T, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.117.006377
   Gao DD, 2018, EUR J MED CHEM, V154, P44, DOI 10.1016/j.ejmech.2018.05.007
   García-Carro C, 2021, J CLIN MED, V10, DOI 10.3390/jcm10112505
   Garg N, 2019, TRANSPLANTATION, V103, P2405, DOI 10.1097/TP.0000000000002663
   Guan YF, 2001, AM J PHYSIOL-RENAL, V281, pF1036, DOI 10.1152/ajprenal.0025.2001
   Guebre-Egziabher F, 2013, BIOCHIMIE, V95, P1971, DOI 10.1016/j.biochi.2013.07.017
   Guo D, 2022, BONE RES, V10, DOI 10.1038/s41413-022-00211-2
   Hami M, 2017, SAUDI J KIDNEY DIS T, V28, P362, DOI 10.4103/1319-2442.202786
   He YL, 2019, BIOORGAN MED CHEM, V27, DOI 10.1016/j.bmc.2019.07.031
   Hertzel AV, 2009, J MED CHEM, V52, P6024, DOI 10.1021/jm900720m
   Hu X, 2017, J DIABETES INVEST, V8, P582, DOI 10.1111/jdi.12611
   Huang IC, 2017, INT J CLIN EXP PATHO, V10, P8727
   Huang RS, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00917
   Kralisch S, 2013, DIABETOLOGIA, V56, P10, DOI 10.1007/s00125-012-2737-4
   Kralisch S, 2015, OBESITY, V23, P1007, DOI 10.1002/oby.21057
   Kühne H, 2016, BIOORG MED CHEM LETT, V26, P5092, DOI 10.1016/j.bmcl.2016.08.071
   Lan H, 2011, J LIPID RES, V52, P646, DOI 10.1194/jlr.M012757
   Lee CH, 2019, DIABETOLOGIA, V62, P169, DOI 10.1007/s00125-018-4742-8
   Lee WC, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17207567
   Leheste JR, 1999, AM J PATHOL, V155, P1361, DOI 10.1016/S0002-9440(10)65238-8
   Li JC, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/8380279
   Li LZ, 2021, INT IMMUNOPHARMACOL, V96, DOI 10.1016/j.intimp.2021.107760
   Liu J, 2021, LIFE SCI, V268, DOI 10.1016/j.lfs.2021.119023
   Martínez-Micaelo N, 2019, BBA-MOL CELL BIOL L, V1864, P234, DOI 10.1016/j.bbalip.2018.11.011
   Mitrofanova A, 2021, WORLD J DIABETES, V12, P524, DOI 10.4239/wjd.v12.i5.524
   Ni XQ, 2018, BIOMED RES INT, V2018, DOI 10.1155/2018/4578140
   Obajdin J, 2018, TOXICOL SCI, V166, P441, DOI 10.1093/toxsci/kfy204
   Okada T, 2012, CHEM PHARM BULL, V60, P164, DOI 10.1248/cpb.60.164
   Okazaki Y, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0115429
   Penno G, 2021, BMC MED, V19, DOI 10.1186/s12916-021-01936-3
   Polenakovic Momir H, 2021, Pril (Makedon Akad Nauk Umet Odd Med Nauki), V42, P19, DOI 10.2478/prilozi-2021-0002
   Rai B, 2025, CURR DIABETES REV, V21, DOI 10.2174/1573399819666220610191935
   Reese-Wagoner A, 1999, BBA-MOL CELL BIOL L, V1441, P106, DOI 10.1016/S1388-1981(99)00154-7
   Ringom R, 2004, BIOORG MED CHEM LETT, V14, P4449, DOI 10.1016/j.bmcl.2004.06.058
   Rolph MS, 2006, J IMMUNOL, V177, P7794, DOI 10.4049/jimmunol.177.11.7794
   Sabatino A, 2021, J NEPHROL, V34, P1347, DOI 10.1007/s40620-020-00840-y
   Samsu N, 2021, BIOMED RES INT, V2021, DOI 10.1155/2021/1497449
   Seo DH, 2020, DIABETES METAB J, V44, P875, DOI 10.4093/dmj.2019.0221
   Shang WF, 2017, PEERJ, V5, DOI 10.7717/peerj.2907
   Shi M, 2020, EUR J PHARMACOL, V887, DOI 10.1016/j.ejphar.2020.173570
   Shi M, 2020, CURR MED CHEM, V27, P3657, DOI 10.2174/0929867325666181008154622
   Shi M, 2018, RSC ADV, V8, P15207, DOI 10.1039/c8ra00122g
   Shinoda Y, 2020, J PHARMACOL SCI, V143, P264, DOI 10.1016/j.jphs.2020.05.005
   Shrestha S, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-34902-w
   Shum BOV, 2006, J CLIN INVEST, V116, P2183, DOI 10.1172/JCI24767
   Smathers Rebecca L., 2011, Human Genomics, V5, P170
   Sommer G, 2008, CLIN ENDOCRINOL, V69, P901, DOI 10.1111/j.1365-2265.2008.03277.x
   SPIEGELMAN BM, 1983, J BIOL CHEM, V258, P83
   Su HX, 2020, J MED CHEM, V63, P4090, DOI 10.1021/acs.jmedchem.9b02107
   Sulsky R, 2007, BIOORG MED CHEM LETT, V17, P3511, DOI 10.1016/j.bmcl.2006.12.044
   Sung CH, 2021, INT J HYPERTENS, V2021, DOI 10.1155/2021/8849115
   Taguchi K, 2020, KIDNEY INT, V97, P1042, DOI 10.1016/j.kint.2020.01.042
   Tan ZK, 2019, J CELL MOL MED, V23, P6260, DOI 10.1111/jcmm.14512
   Tanaka M, 2020, BMC NEPHROL, V21, DOI 10.1186/s12882-020-02122-y
   Tanaka M, 2014, NEPHRON CLIN PRACT, V128, P345, DOI 10.1159/000368412
   Toruner F, 2011, DIABETES RES CLIN PR, V91, P203, DOI 10.1016/j.diabres.2010.11.011
   Tsai JP, 2010, ARCH MED RES, V41, P536, DOI 10.1016/j.arcmed.2010.09.007
   Uribarri J, 2020, CURR OPIN NEPHROL HY, V29, P237, DOI 10.1097/MNH.0000000000000582
   Wang B, 2022, CELL DEATH DIS, V13, DOI 10.1038/s41419-022-04794-w
   Wang Y, 2016, PHYTOMEDICINE, V23, P1469, DOI 10.1016/j.phymed.2016.08.008
   Wang Y, 2015, ACS CHEM NEUROSCI, V6, P211, DOI 10.1021/cn5002107
   World Health Organization, 2020, The top 10 causes of death
   Wu YW, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21239245
   Xie XT, 2016, OBESITY, V24, P1506, DOI 10.1002/oby.21528
   Yang SL, 2022, RSC ADV, V12, P13500, DOI 10.1039/d2ra01057g
   Yao F, 2020, EUR REV MED PHARMACO, V24, P12808, DOI 10.26355/eurrev_202012_24182
   Yao F, 2015, MOL CELL ENDOCRINOL, V411, P232, DOI 10.1016/j.mce.2015.05.003
   Yeung DCY, 2009, DIABETES CARE, V32, P132, DOI 10.2337/dc08-1333
   Zhang MM, 2014, MED CHEM, V10, P339, DOI 10.2174/15734064113096660045
   Zhou SJ, 2021, RENAL FAILURE, V43, P1539, DOI 10.1080/0886022X.2021.2003205
   Zhu QY, 2015, CELL BIOL INT, V39, P540, DOI 10.1002/cbin.10429
   Zhuang LF, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.722908
NR 102
TC 6
Z9 6
U1 2
U2 16
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD SEP 15
PY 2022
VL 931
AR 175224
DI 10.1016/j.ejphar.2022.175224
EA AUG 2022
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 4Y1WJ
UT WOS:000861322300001
PM 35995212
DA 2025-06-11
ER

PT J
AU Pistell, PJ
   Morrison, CD
   Gupta, S
   Knight, AG
   Keller, JN
   Ingram, DK
   Bruce-Keller, AJ
AF Pistell, Paul J.
   Morrison, Christopher D.
   Gupta, Sunita
   Knight, Alecia G.
   Keller, Jeffrey N.
   Ingram, Donald K.
   Bruce-Keller, Annadora J.
TI Cognitive impairment following high fat diet consumption is associated
   with brain inflammation
SO JOURNAL OF NEUROIMMUNOLOGY
LA English
DT Article
DE Metabolic syndrome; Neurodegeneration; Obesity; Oxidative stress;
   Western diet
ID NF-KAPPA-B; OXIDATIVE STRESS; LEPTIN RECEPTOR; METABOLIC COMPLICATIONS;
   GLUTAMATE RELEASE; DENTATE GYRUS; SATURATED FAT; OBESITY; HIPPOCAMPAL;
   EXPRESSION
AB C57Bl/6 truce were administered a high fat, Western diet (WD, 41% fat) or a very high fat lard diet (HFL, 60% fat). and evaluated I'm cognitive ability using the Stone T-maze and for biochemical markers of brain inflammation WD consumption resulted in significantly increased body weight and astrocyte reactivity. but not impaired cognition, microglial reactivity, or heightened cytokine levels. HFL. increased body weight. and impaired cognition. increased brain inflammation. and decreased BDNF. Collectively, these data suggest that while different diet formulations can increase body weight. the ability of high fat diets to disrupt cognition is linked to brain inflammation (C) 2009 Elsevier B V. All rights reserved
C1 [Pistell, Paul J.; Morrison, Christopher D.; Gupta, Sunita; Knight, Alecia G.; Keller, Jeffrey N.; Ingram, Donald K.; Bruce-Keller, Annadora J.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center
RP Bruce-Keller, AJ (corresponding author), Louisiana State Univ, Pennington Biomed Res Ctr, Inflammat & Neurodegenerat Lab, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
RI Keller, Jeffrey/N-1975-2017; Bruce-Keller, Annadora/N-1954-2017;
   Morrison, Christopher/A-6093-2010
OI Morrison, Christopher/0000-0002-5492-102X; keller,
   jeffrey/0000-0002-9892-7423
FU NIH [NS46267, DA19398, AG05119, NS051570, RR021945, P20-RR021945,
   P30-DK072476]
FX The authors are grateful to Megan Purpera and Sun-Ok FernandezKim for
   expert technical assistance and animal handling This work was supported
   by grants from the NIH (NS46267. DA19398, and AG05119 to AJB-K; NS051570
   and RR021945 to CDM). This study also used PBRC Core facilities (Animal
   Phenotyping) that are funded by the NIH (P20-RR021945 and P30-DK072476).
CR Ahima RS, 2008, FRONT HORM RES, V36, P182, DOI 10.1159/000115365
   Ahmed Z, 2007, J HISTOCHEM CYTOCHEM, V55, P687, DOI 10.1369/jhc.6A7156.2007
   Aronis A, 2008, NUTRITION, V24, P167, DOI 10.1016/j.nut.2007.10.017
   Atzmon G, 2002, J GERONTOL A-BIOL, V57, pM712, DOI 10.1093/gerona/57.11.M712
   Averill MM, 2009, CURR DIABETES REP, V9, P18, DOI 10.1007/s11892-009-0005-x
   Banks WA, 1996, PEPTIDES, V17, P305, DOI 10.1016/0196-9781(96)00025-3
   Baran SE, 2005, NEUROREPORT, V16, P39, DOI 10.1097/00001756-200501190-00010
   Barger SW, 2007, J NEUROCHEM, V101, P1205, DOI 10.1111/j.1471-4159.2007.04487.x
   Barrientos RM, 2006, NEUROBIOL AGING, V27, P723, DOI 10.1016/j.neurobiolaging.2005.03.010
   BELLINGER FP, 1995, NEUROSCI LETT, V198, P95, DOI 10.1016/0304-3940(95)11976-4
   Benveniste EN, 2001, NEUROCHEM INT, V39, P381, DOI 10.1016/S0197-0186(01)00045-6
   Brinton RD, 2008, ADV DRUG DELIVER REV, V60, P1504, DOI 10.1016/j.addr.2008.06.003
   Bruce-Keller AJ, 2001, J NEUROCHEM, V78, P1315, DOI 10.1046/j.1471-4159.2001.00511.x
   Bruce-Keller AJ, 2009, BBA-MOL BASIS DIS, V1792, P395, DOI 10.1016/j.bbadis.2008.10.004
   Chandalia M, 2007, J DIABETES COMPLICAT, V21, P128, DOI 10.1016/j.jdiacomp.2006.10.004
   Chen B, 2009, BRAIN RES, V1273, P129, DOI 10.1016/j.brainres.2009.04.002
   Chen PQ, 1997, J BIOL CHEM, V272, P22385, DOI 10.1074/jbc.272.36.22385
   Combs CK, 2009, J NEUROIMMUNE PHARM, V4, P380, DOI 10.1007/s11481-009-9165-3
   Croll SD, 1998, BRAIN RES, V812, P200, DOI 10.1016/S0006-8993(98)00993-7
   de Vries A, 2009, CLIN EXP ALLERGY, V39, P731, DOI 10.1111/j.1365-2222.2008.03179.x
   Elias MF, 2003, INT J OBESITY, V27, P260, DOI 10.1038/sj.ijo.802225
   Elias MF, 2005, NEUROBIOL AGING, V26, pS11, DOI 10.1016/j.neurobiolaging.2005.08.019
   Elmquist JK, 1998, J COMP NEUROL, V395, P535
   Espey MG, 1998, J NEUROCHEM, V71, P2079
   Farr SA, 2008, ENDOCRINOLOGY, V149, P2628, DOI 10.1210/en.2007-1722
   Fei H, 1997, P NATL ACAD SCI USA, V94, P7001, DOI 10.1073/pnas.94.13.7001
   Gazdzinski S, 2008, ANN NEUROL, V63, P652, DOI 10.1002/ana.21377
   Gemma C, 2007, REV NEUROSCIENCE, V18, P137
   Granholm AC, 2008, J ALZHEIMERS DIS, V14, P133
   Harvey J, 2005, BIOCHEM SOC T, V33, P1029, DOI 10.1042/BST0331029
   Haslam DW, 2005, LANCET, V366, P1197, DOI 10.1016/S0140-6736(05)67483-1
   Hilton GD, 2008, J CEREBR BLOOD F MET, V28, P1845, DOI 10.1038/jcbfm.2008.75
   Hooijmans CR, 2009, NEUROBIOL DIS, V33, P482, DOI 10.1016/j.nbd.2008.12.002
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Jagust W, 2007, CURR ALZHEIMER RES, V4, P135, DOI 10.2174/156720507780362146
   Jankowsky JL, 1999, MOL CELL NEUROSCI, V14, P273, DOI 10.1006/mcne.1999.0792
   Jovanovic JN, 2000, NAT NEUROSCI, V3, P323, DOI 10.1038/73888
   Kadish I, 2009, J NEUROSCI, V29, P1805, DOI 10.1523/JNEUROSCI.4599-08.2009
   Kennedy A, 2009, J NUTR, V139, P1, DOI 10.3945/jn.108.098269
   Kovalchuk Y, 2002, SCIENCE, V295, P1729, DOI 10.1126/science.1067766
   Laine PS, 2007, BIOCHEM BIOPH RES CO, V358, P150, DOI 10.1016/j.bbrc.2007.04.092
   Lee CH, 2008, J VET MED SCI, V70, P1405, DOI 10.1292/jvms.70.1405
   Luchsinger JA, 2009, J ALZHEIMERS DIS, V16, P693, DOI 10.3233/JAD-2009-1022
   Ma D, 2008, HIPPOCAMPUS, V18, P326, DOI 10.1002/hipo.20393
   Mankowski JL, 2004, J NEUROIMMUNOL, V157, P66, DOI 10.1016/j.jneuroim.2004.08.031
   Mascarucci P, 1998, NEUROSCIENCE, V86, P1285, DOI 10.1016/S0306-4522(98)00105-5
   McGeer EG, 1997, MOVEMENT DISORD, V12, P855, DOI 10.1002/mds.870120604
   Milanski M, 2009, J NEUROSCI, V29, P359, DOI 10.1523/JNEUROSCI.2760-08.2009
   Monje ML, 2003, SCIENCE, V302, P1760, DOI 10.1126/science.1088417
   Morrison CD, 2009, BBA-MOL BASIS DIS, V1792, P401, DOI 10.1016/j.bbadis.2008.12.004
   O'Callaghan James P, 2005, Expert Opin Drug Saf, V4, P433, DOI 10.1517/14740338.4.3.433
   Oomura Y, 2006, PEPTIDES, V27, P2738, DOI 10.1016/j.peptides.2006.07.001
   Ouchi N, 2007, CLIN CHIM ACTA, V380, P24, DOI 10.1016/j.cca.2007.01.026
   Pannacciulli N, 2006, NEUROIMAGE, V31, P1419, DOI 10.1016/j.neuroimage.2006.01.047
   Parnet P, 2002, J NEUROIMMUNOL, V125, P5, DOI 10.1016/S0165-5728(02)00022-X
   Patil S, 2005, NEUROSCI LETT, V384, P288, DOI 10.1016/j.neulet.2005.05.003
   Perlmuter L C, 1988, J Diabet Complications, V2, P210, DOI 10.1016/S0891-6632(88)80011-4
   Pickup JC, 1998, DIABETOLOGIA, V41, P1241, DOI 10.1007/s001250051058
   Pinteaux E, 2007, J NEUROCHEM, V102, P826, DOI 10.1111/j.1471-4159.2007.04559.x
   Pistell PJ, 2009, BEHAV BRAIN RES, V197, P138, DOI 10.1016/j.bbr.2008.08.015
   Rader DJ, 2000, NEW ENGL J MED, V343, P1179, DOI 10.1056/NEJM200010193431609
   Rasouli N, 2008, J CLIN ENDOCR METAB, V93, pS64, DOI 10.1210/jc.2008-1613
   Reitz C, 2005, NEUROLOGY, V64, P1378, DOI 10.1212/01.WNL.0000158274.31318.3C
   Rogers J, 2007, INT REV NEUROBIOL, V82, P235, DOI 10.1016/S0074-7742(07)82012-5
   ROGERS RL, 1989, ANGIOLOGY, V40, P260, DOI 10.1177/000331978904000404
   SENA A, 1985, J NEUROL SCI, V68, P233, DOI 10.1016/0022-510X(85)90104-2
   Shoelson SE, 2007, GASTROENTEROLOGY, V132, P2169, DOI 10.1053/j.gastro.2007.03.059
   Silva MC, 2005, NUTR NEUROSCI, V8, P259, DOI 10.1080/10284150500475032
   Sparkman NL, 2006, J NEUROSCI, V26, P10709, DOI 10.1523/JNEUROSCI.3376-06.2006
   Sparks DL, 2005, ARCH NEUROL-CHICAGO, V62, P753, DOI 10.1001/archneur.62.5.753
   Streit WJ, 2008, FRONT BIOSCI-LANDMRK, V13, P3423
   Studzinski CM, 2009, J NEUROCHEM, V108, P860, DOI 10.1111/j.1471-4159.2008.05798.x
   Tanaka S, 2006, J NEUROSCI RES, V83, P557, DOI 10.1002/jnr.20752
   Tang CH, 2007, J IMMUNOL, V179, P1292, DOI 10.4049/jimmunol.179.2.1292
   Tartaglia LA, 1995, CELL, V83, P1263, DOI 10.1016/0092-8674(95)90151-5
   Vega-Avelaira D, 2007, BRAIN BEHAV IMMUN, V21, P617, DOI 10.1016/j.bbi.2006.10.007
   Waldstein SR, 2006, INT J OBESITY, V30, P201, DOI 10.1038/sj.ijo.0803114
   Ward MA, 2005, BMC NEUROL, V5, DOI 10.1186/1471-2377-5-23
   Wayner MJ, 2004, PEPTIDES, V25, P991, DOI 10.1016/j.peptides.2004.03.018
   White CL, 2009, NEUROBIOL DIS, V35, P3, DOI 10.1016/j.nbd.2009.04.002
   Willard LB, 2000, EXP BRAIN RES, V134, P58, DOI 10.1007/s002210000446
   Winocur G, 2005, NEUROBIOL AGING, V26, pS46, DOI 10.1016/j.neurobiolaging.2005.09.003
   Wu AG, 2004, EUR J NEUROSCI, V19, P1699, DOI 10.1111/j.1460-9568.2004.03246.x
   Zecca L, 2008, ACTA NEUROPATHOL, V116, P47, DOI 10.1007/s00401-008-0361-7
   Zhao Q, 2004, PEDIATR RES, V55, P498, DOI 10.1203/01.PDR.0000112032.47575.D1
NR 85
TC 469
Z9 529
U1 6
U2 77
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-5728
EI 1872-8421
J9 J NEUROIMMUNOL
JI J. Neuroimmunol.
PD FEB 26
PY 2010
VL 219
IS 1-2
BP 25
EP 32
DI 10.1016/j.jneuroim.2009.11.010
PG 8
WC Immunology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology
GA 570NA
UT WOS:000275683800004
PM 20004026
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Dancsó, B
   Spiró, Z
   Arslan, MA
   Nguyen, MT
   Papp, D
   Csermely, P
   Soti, C
AF Dancso, Balazs
   Spiro, Zoltan
   Arslan, Mehmet Alper
   Nguyen, Minh Tu
   Papp, Diana
   Csermely, Peter
   Soti, Csaba
TI The Heat Shock Connection of Metabolic Stress and Dietary Restriction
SO CURRENT PHARMACEUTICAL BIOTECHNOLOGY
LA English
DT Review
DE Aging; caloric restriction; diabetes; heat shock response; resveratrol;
   sirtuin
ID LIFE-SPAN EXTENSION; CALORIC RESTRICTION; CAENORHABDITIS-ELEGANS;
   MOLECULAR CHAPERONES; CELLULAR NETWORKS; IN-VIVO;
   DROSOPHILA-MELANOGASTER; TRANSCRIPTION FACTORS; ENDOCRINE REGULATION;
   INSULIN-RESISTANCE
AB Molecular chaperones and the heat shock response guard and modulate protein conformation, protect proteins from misfolding and aggregation, and maintain signalling and organellar networks. Overnutrition and the metabolic syndrome represent a pro-aging condition, and dietary restriction is the most robust environmental intervention that induces longevity from yeast to mammals. In recent years a considerable effort has been made to elucidate the signaling pathways involved in metabolic signaling. Here we review the current understanding on the connection between metabolic stress, dietary restriction and the heat shock response and highlight results showing chaperone induction as a promising therapeutic strategy to promote healthy aging and to prevent metabolic disorders.
C1 [Dancso, Balazs; Spiro, Zoltan; Arslan, Mehmet Alper; Nguyen, Minh Tu; Papp, Diana; Csermely, Peter; Soti, Csaba] Semmelweis Univ, Dept Med Chem, Budapest, Hungary.
C3 Semmelweis University
RP Soti, C (corresponding author), Semmelweis Univ, Dept Med Chem, Budapest, Hungary.
EM csaba.soti@eok.sote.hu
RI Csermely, Peter/J-2067-2017; Sőti, Csaba/O-6070-2017; Papp,
   Diana/K-3921-2015; Arslan, Mehmet Alper/HDO-4459-2022
OI Soti, Csaba/0000-0002-4057-7678; Papp, Diana/0000-0002-2732-7543; Papp,
   Diana/0000-0001-5001-5719; Csermely, Peter/0000-0001-9234-0659; Arslan,
   Mehmet Alper/0000-0002-3113-7195
FU EU [FP6-518230, PROTEOMAGE, FP7-200970, WhyWeAge]; Hungarian Science
   Foundation [OTKA K69105, NNF-78794]
FX Work in the authors' laboratory was supported by a research grant from
   the EU (FP6-518230, PROTEOMAGE; FP7-200970, WhyWeAge), from the
   Hungarian Science Foundation (OTKA K69105) and from a joint grant of the
   Hungarian Science Foundation and Norway Grants (NNF-78794). C. S. is a
   Bolyai Research Scholar of the Hungarian Academy of Sciences. The
   authors have declared that no competing interests exist.
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Allard JS, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003211
   Atalay M, 2009, CURR PROTEIN PEPT SC, V10, P85, DOI 10.2174/138920309787315202
   Banks AS, 2008, CELL METAB, V8, P333, DOI 10.1016/j.cmet.2008.08.014
   Bass TM, 2007, MECH AGEING DEV, V128, P546, DOI 10.1016/j.mad.2007.07.007
   Baur JA, 2006, NATURE, V444, P337, DOI 10.1038/nature05354
   Baur JA, 2006, NAT REV DRUG DISCOV, V5, P493, DOI 10.1038/nrd2060
   Bishop NA, 2007, NATURE, V447, P545, DOI 10.1038/nature05904
   Boily G, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001759
   Brunet A, 2004, SCIENCE, V303, P2011, DOI 10.1126/science.1094637
   Bukau B, 2006, CELL, V125, P443, DOI 10.1016/j.cell.2006.04.014
   Calabrese EJ, 2006, BIOGERONTOLOGY, V7, P119, DOI 10.1007/s10522-006-0005-z
   Cao SX, 2001, P NATL ACAD SCI USA, V98, P10630, DOI 10.1073/pnas.191313598
   Chung J, 2008, P NATL ACAD SCI USA, V105, P1739, DOI 10.1073/pnas.0705799105
   Colotti C, 2005, BIOGERONTOLOGY, V6, P397, DOI 10.1007/s10522-005-4906-z
   Cuervo AM, 2008, J GERONTOL A-BIOL, V63, P547, DOI 10.1093/gerona/63.6.547
   Cypser JR, 2002, J GERONTOL A-BIOL, V57, pB109, DOI 10.1093/gerona/57.3.B109
   Dai C, 2007, CELL, V130, P1005, DOI 10.1016/j.cell.2007.07.020
   Davis BJ, 2006, DIABETES, V55, P496, DOI 10.2337/diabetes.55.02.06.db05-1064
   Denegri M, 2001, MOL BIOL CELL, V12, P3502, DOI 10.1091/mbc.12.11.3502
   Deuerling E, 2004, CRIT REV BIOCHEM MOL, V39, P261, DOI 10.1080/10409230490892496
   Donati A, 2008, J GERONTOL A-BIOL, V63, P550, DOI 10.1093/gerona/63.6.550
   Duan WZ, 2003, P NATL ACAD SCI USA, V100, P2911, DOI 10.1073/pnas.0536856100
   Ehrenfried JA, 1996, ANN SURG, V223, P592, DOI 10.1097/00000658-199605000-00015
   Epel ES, 2009, HORM-INT J ENDOCRINO, V8, P7, DOI 10.14310/horm.2002.1217
   Frier B, 2005, EXP GERONTOL, V40, P615, DOI 10.1016/j.exger.2005.04.011
   Gabai VL, 2002, J APPL PHYSIOL, V92, P1743, DOI 10.1152/japplphysiol.01101.2001
   Garigan D, 2002, GENETICS, V161, P1101
   Giannakou ME, 2008, AGING CELL, V7, P187, DOI 10.1111/j.1474-9726.2007.00362.x
   Greer EL, 2007, CURR BIOL, V17, P1646, DOI 10.1016/j.cub.2007.08.047
   Greer EL, 2009, AGING CELL, V8, P113, DOI 10.1111/j.1474-9726.2009.00459.x
   Gruber J, 2007, ANN NY ACAD SCI, V1100, P530, DOI 10.1196/annals.1395.059
   Guo ZH, 2000, EXP NEUROL, V166, P173, DOI 10.1006/exnr.2000.7497
   Gupte AA, 2009, DIABETES, V58, P567, DOI 10.2337/db08-1070
   Hahn JS, 2004, MOL CELL BIOL, V24, P5249, DOI 10.1128/MCB.24.12.5249-5256.2004
   Hall DM, 2000, FASEB J, V14, P78, DOI 10.1096/fasebj.14.1.78
   Hansen M, 2008, PLOS GENET, V4, DOI 10.1371/journal.pgen.0040024
   Hansen M, 2007, AGING CELL, V6, P95, DOI 10.1111/j.1474-9726.2006.00267.x
   Hartl FU, 2002, SCIENCE, V295, P1852, DOI 10.1126/science.1068408
   Heydari AR, 1996, DEV GENET, V18, P114, DOI 10.1002/(SICI)1520-6408(1996)18:2<114::AID-DVG4>3.0.CO;2-C
   HEYDARI AR, 1993, MOL CELL BIOL, V13, P2909, DOI 10.1128/MCB.13.5.2909
   Hooper PL, 2009, CELL STRESS CHAPERON, V14, P113, DOI 10.1007/s12192-008-0073-x
   Houthoofd K, 2006, EXP GERONTOL, V41, P1026, DOI 10.1016/j.exger.2006.05.007
   Howitz KT, 2003, NATURE, V425, P191, DOI 10.1038/nature01960
   Hsu AL, 2003, SCIENCE, V300, P1142, DOI 10.1126/science.1083701
   Jolly C, 1999, P NATL ACAD SCI USA, V96, P6769, DOI 10.1073/pnas.96.12.6769
   Kaeberlein TL, 2006, AGING CELL, V5, P487, DOI 10.1111/j.1474-9726.2006.00238.x
   Kahn SE, 2006, NATURE, V444, P840, DOI 10.1038/nature05482
   Kaniuk NA, 2007, DIABETES, V56, P930, DOI 10.2337/db06-1160
   Kavanagh K, 2009, CELL STRESS CHAPERON, V14, P291, DOI 10.1007/s12192-008-0084-7
   Kayo T, 2001, P NATL ACAD SCI USA, V98, P5093, DOI 10.1073/pnas.081061898
   Kenyon C, 2005, CELL, V120, P449, DOI 10.1016/j.cell.2005.02.002
   Kim D, 2007, EMBO J, V26, P3169, DOI 10.1038/sj.emboj.7601758
   Kumar PA, 2007, BIOCHEM J, V408, P251, DOI 10.1042/BJ20070989
   Kürthy M, 2002, ANN NY ACAD SCI, V967, P482
   Kurucz I, 2002, DIABETES, V51, P1102, DOI 10.2337/diabetes.51.4.1102
   Lakowski B, 1998, P NATL ACAD SCI USA, V95, P13091, DOI 10.1073/pnas.95.22.13091
   Lee GD, 2006, AGING CELL, V5, P515, DOI 10.1111/j.1474-9726.2006.00241.x
   Lee J, 1999, J NEUROSCI RES, V57, P48, DOI 10.1002/(SICI)1097-4547(19990701)57:1<48::AID-JNR6>3.3.CO;2-C
   Lei HT, 2007, J BIOL CHEM, V282, P9364, DOI 10.1074/jbc.M608985200
   Lenaerts I, 2008, J GERONTOL A-BIOL, V63, P242, DOI 10.1093/gerona/63.3.242
   Lin SJ, 2000, SCIENCE, V289, P2126, DOI 10.1126/science.289.5487.2126
   Literáti-Nagy B, 2009, HORM METAB RES, V41, P374, DOI 10.1055/s-0028-1128142
   Masoro EJ, 2005, MECH AGEING DEV, V126, P913, DOI 10.1016/j.mad.2005.03.012
   McClellan AJ, 2007, CELL, V131, P121, DOI 10.1016/j.cell.2007.07.036
   Mohan S, 2009, AM J PHYSIOL-CELL PH, V296, pC182, DOI 10.1152/ajpcell.00575.2007
   Morimoto RI, 1998, GENE DEV, V12, P3788, DOI 10.1101/gad.12.24.3788
   Morimoto RI, 2008, GENE DEV, V22, P1427, DOI 10.1101/gad.1657108
   Morimoto RI, 2009, J GERONTOL A-BIOL, V64, P167, DOI 10.1093/gerona/gln071
   Morley JF, 2004, MOL BIOL CELL, V15, P657, DOI 10.1091/mbc.E03-07-0532
   Morley JF, 2002, P NATL ACAD SCI USA, V99, P10417, DOI 10.1073/pnas.152161099
   Nemoto S, 2005, J BIOL CHEM, V280, P16456, DOI 10.1074/jbc.M501485200
   Palotai R, 2008, IUBMB LIFE, V60, P10, DOI 10.1002/iub.8
   Panowski SH, 2007, NATURE, V447, P550, DOI 10.1038/nature05837
   Parker JA, 2005, NAT GENET, V37, P349, DOI 10.1038/ng1534
   Pearson KJ, 2008, CELL METAB, V8, P157, DOI 10.1016/j.cmet.2008.06.011
   Pfluger PT, 2008, P NATL ACAD SCI USA, V105, P9793, DOI 10.1073/pnas.0802917105
   Picard F, 2004, NATURE, V429, P771, DOI 10.1038/nature02583
   Pirkkala L, 2001, FASEB J, V15, P1118, DOI 10.1096/fj00-0294rev
   Putics A, 2008, ANTIOXID REDOX SIGN, V10, P65, DOI 10.1089/ars.2007.1866
   Rangaraju S, 2009, AGING CELL, V8, P178, DOI 10.1111/j.1474-9726.2009.00460.x
   Rea SL, 2005, NAT GENET, V37, P894, DOI 10.1038/ng1608
   Roigas J, 2004, INT J HYPERTHER, V20, P557, DOI 10.1080/02656730310001625229
   Ron D, 2007, NAT REV MOL CELL BIO, V8, P519, DOI 10.1038/nrm2199
   SARGE KD, 1993, MOL CELL BIOL, V13, P1392, DOI 10.1128/MCB.13.3.1392
   Selsby JT, 2005, EXP GERONTOL, V40, P37, DOI 10.1016/j.exger.2004.08.012
   Shamovsky I, 2008, CELL MOL LIFE SCI, V65, P855, DOI 10.1007/s00018-008-7458-y
   Shamovsky I, 2006, NATURE, V440, P556, DOI 10.1038/nature04518
   Smith ED, 2008, BMC DEV BIOL, V8, DOI 10.1186/1471-213X-8-49
   Söti C, 2007, J BIOSCIENCES, V32, P511, DOI 10.1007/s12038-007-0050-z
   Soti C, 2007, EXP GERONTOL, V42, P113, DOI 10.1016/j.exger.2006.05.017
   Söti C, 2005, CURR OPIN CELL BIOL, V17, P210, DOI 10.1016/j.ceb.2005.02.012
   Steinkraus KA, 2008, AGING CELL, V7, P394, DOI 10.1111/j.1474-9726.2008.00385.x
   Syntichaki P, 2007, NATURE, V445, P922, DOI 10.1038/nature05603
   Szalay MS, 2007, FEBS LETT, V581, P3675, DOI 10.1016/j.febslet.2007.03.083
   Tatar M, 2003, SCIENCE, V299, P1346, DOI 10.1126/science.1081447
   Tissenbaum HA, 2001, NATURE, V410, P227, DOI 10.1038/35065638
   Tóth ML, 2008, AUTOPHAGY, V4, P330, DOI 10.4161/auto.5618
   Viswanathan M, 2005, DEV CELL, V9, P605, DOI 10.1016/j.devcel.2005.09.017
   Wang YQ, 2009, CARDIOVASC RES, V82, P484, DOI 10.1093/cvr/cvp078
   Wang YM, 2006, MECH AGEING DEV, V127, P48, DOI 10.1016/j.mad.2005.09.005
   Weighardt F, 1999, J CELL SCI, V112, P1465
   Weindruch R, 1997, NEW ENGL J MED, V337, P986, DOI 10.1056/NEJM199710023371407
   Westerheide SD, 2009, SCIENCE, V323, P1063, DOI 10.1126/science.1165946
   Wood JG, 2004, NATURE, V430, P686, DOI 10.1038/nature02789
   Xiao XZ, 1999, EMBO J, V18, P5943, DOI 10.1093/emboj/18.21.5943
   Yang JS, 2009, J GERONTOL A-BIOL, V64, P828, DOI 10.1093/gerona/glp054
NR 107
TC 12
Z9 14
U1 1
U2 10
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-2010
EI 1873-4316
J9 CURR PHARM BIOTECHNO
JI Curr. Pharm. Biotechnol.
PD FEB
PY 2010
VL 11
IS 2
BP 139
EP 145
DI 10.2174/138920110790909704
PG 7
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 568IX
UT WOS:000275517100002
PM 20166967
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Poyraz, N
   Özer, H
   Baloglu, I
   Kadiyoran, C
   Yilmaz, PD
   Sertdemir, AL
   Türkmen, K
AF Poyraz, Necdet
   Ozer, Hakan
   Baloglu, Ismail
   Kadiyoran, Cengiz
   Yilmaz, Pinar Diydem
   Sertdemir, Ahmet Lutfu
   Turkmen, Kultigin
TI Liver-Spleen Ratio: Can It Be Used for the Prediction of Coronary Artery
   Disease?
SO ANATOLIAN JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Liver-spleen ratio; hepatosteatosis; epicardial adipose tissue;
   cardiovascular disease
ID EPICARDIAL ADIPOSE-TISSUE; TO-LYMPHOCYTE RATIO; FATTY LIVER; METABOLIC
   SYNDROME; COMPUTED-TOMOGRAPHY; OXIDATIVE STRESS; THICKNESS; CT;
   DIAGNOSIS; OBESITY
AB Background: Considering that ectopic fat accumulation in various organs, especially the heart and liver, is a cardiometabolic risk factor, the need for easily accessible markers of ectopic fat accumulation is inevitable. The main starting point of the study is based on the hypothesis of predicting cardiovascular disease risk through the link that can be established between the liver-spleen ratio, which is one of the strong indicators of hepatosteatosis, and epicardial adipose tissue volume.
   Methods: This was a retrospective study. The records of 283 consecutive patients who underwent coronary computed tomography angiography in our Radiology Department were reviewed retrospectively from our hospital's system. All patients' epicardial adipose tissue volume and liver-spleen ratio were calculated using appropriate criteria on non-contrast computed tomography images. Additionally, the Coronary Artery Disease-Reporting and Data System was calculated on contrast computed tomography images. The participating patients were divided into groups according to the liver-spleen ratio and Coronary Artery Disease-Reporting and Data System score.
   Results: We found that while there was a negative correlation between the liver-spleen ratio and epicardial adipose tissue volume in the hepatosteatosis group, this relationship was not observed in the non-steatosis group. In addition, we observed that the family history of cardiovascular disease and the frequency of cardiovascular disease were higher in the hepatosteatosis group than in the other group, and there was a correlation between cardiovascular disease and the liver-spleen ratio. Also, we found that age and liver- spleen ratio values were found to be independent predictors of coronary artery disease.
   Conclusion: In our study, we found that the frequency of cardiovascular disease was lower in patients with a high liver-spleen ratio. We also demonstrated in the study that the liver-spleen ratio, which indicates a low level of epicardial adipose tissue volume accumulation, is an independent predictor of cardiovascular disease. In addition, the use of liver-spleen ratio, which is more valuable than liver attenuation in predicting hepatic steatosis, may be more useful in evaluating the risk of hepatosteatosis-related cardiovascular disease.
C1 [Poyraz, Necdet; Kadiyoran, Cengiz; Yilmaz, Pinar Diydem] Necmettin Erbakan Univ, Meram Fac Med, Dept Radiol, Konya, Turkey.
   [Ozer, Hakan; Turkmen, Kultigin] Necmettin Erbakan Univ, Meram Fac Med, Dept Nephrol, Konya, Turkey.
   [Baloglu, Ismail] Omer Halisdemir Univ Training & Res Hosp, Dept Nephrol, Nigde, Turkey.
   [Sertdemir, Ahmet Lutfu] Necmettin Erbakan Univ, Meram Fac Med, Dept Cardiol, Konya, Turkey.
C3 Necmettin Erbakan University; Necmettin Erbakan University; Nigde Omer
   Halisdemir University; Necmettin Erbakan University
RP Özer, H (corresponding author), Necmettin Erbakan Univ, Meram Fac Med, Dept Nephrol, Konya, Turkey.
EM hakanozer724@gmail.com
RI KADIYORAN, Cengiz/AAH-6564-2021; Turkmen, Kultigin/AFR-4244-2022;
   Poyraz, Necdet/AAP-2172-2020; Özer, Hakan/HKN-9433-2023; Yilmaz,
   Pinar/AAH-5763-2021
OI Yilmaz, Pinar Diydem/0000-0002-8519-5382; Turkmen,
   Kultigin/0000-0002-1667-7716; OZER, Hakan/0000-0001-9174-0351
CR Akbas EM, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-55
   Akbas EM, 2014, INT J CLIN EXP MED, V7, P1794
   Altin C, 2018, J OBSTET GYNAECOL RE, V44, P1072, DOI 10.1111/jog.13631
   Apostolopoulou M, 2018, DIABETES CARE, V41, P1235, DOI 10.2337/dc17-1318
   Aprigliano G, 2015, INT J CARDIOL, V199, P8, DOI 10.1016/j.ijcard.2015.06.168
   Aydin H, 2010, METAB SYNDR RELAT D, V8, P229, DOI 10.1089/met.2009.0080
   Baloglu I, 2021, EXP CLIN ENDOCR DIAB, V129, P390, DOI 10.1055/a-0892-4290
   Brunt EM, 2002, BEST PRACT RES CL GA, V16, P691, DOI 10.1053/bega.2002.0326
   Cheng KH, 2008, INT J OBESITY, V32, P268, DOI 10.1038/sj.ijo.0803726
   Cho KI, 2017, METAB SYNDR RELAT D, V15, P226, DOI 10.1089/met.2016.0132
   D'Marco LG, 2013, NEPHROL DIAL TRANSPL, V28, P2586, DOI 10.1093/ndt/gft264
   de Feyter PJ, 2011, CLIN CARDIOL, V34, P143, DOI 10.1002/clc.20893
   Golabi P, 2018, MEDICINE, V97, DOI [10.1097/MD.0000000000010214, 10.1097/md.0000000000010214]
   Gorter PM, 2008, ATHEROSCLEROSIS, V197, P896, DOI 10.1016/j.atherosclerosis.2007.08.016
   Iacobellis G, 2003, J CLIN ENDOCR METAB, V88, P5163, DOI 10.1210/jc.2003-030698
   Iacobellis G, 2009, HORM METAB RES, V41, P227, DOI 10.1055/s-0028-1100412
   Iacobellis G, 2008, OBESITY, V16, P179, DOI 10.1038/oby.2007.50
   Iacobellis G, 2015, NAT REV ENDOCRINOL, V11, P363, DOI 10.1038/nrendo.2015.58
   Iacobellis G, 2014, OBESITY, V22, P332, DOI 10.1002/oby.20624
   Iacobellis G, 2009, J AM SOC ECHOCARDIOG, V22, P1311, DOI 10.1016/j.echo.2009.10.013
   Iozzo P, 2011, DIABETES CARE, V34, pS371, DOI 10.2337/dc11-s250
   Iwasaki M, 2004, TRANSPLANTATION, V78, P1501, DOI 10.1097/01.TP.0000140499.23683.0D
   Johnston RJ, 1998, ABDOM IMAGING, V23, P409, DOI 10.1007/s002619900370
   Joy D, 2003, EUR J GASTROEN HEPAT, V15, P539, DOI 10.1097/01.meg.0000059112.41030.2e
   Kankaanpää M, 2006, J CLIN ENDOCR METAB, V91, P4689, DOI 10.1210/jc.2006-0584
   Karatas A, 2018, BRATISL MED J, V119, P566, DOI 10.4149/BLL_2018_102
   Kodama Y, 2007, AM J ROENTGENOL, V188, P1307, DOI 10.2214/AJR.06.0992
   Kotronen A, 2008, ARTERIOSCL THROM VAS, V28, P27, DOI 10.1161/ATVBAHA.107.147538
   Lacobellis G, 2008, HORM METAB RES, V40, P442, DOI 10.1055/s-2008-1062724
   Le Jemtel TH, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0880-0
   Lin A, 2021, CARDIOVASC DIABETOL, V20, DOI 10.1186/s12933-021-01220-x
   Lin HH, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-127
   Ma XZ, 2009, RADIOGRAPHICS, V29, P1253, DOI 10.1148/rg.295085186
   Mazurek T, 2003, CIRCULATION, V108, P2460, DOI 10.1161/01.CIR.0000099542.57313.C5
   MILLS SR, 1977, J COMPUT ASSIST TOMO, V1, P101, DOI 10.1097/00004728-197701000-00012
   Nakanishi K, 2014, ATHEROSCLEROSIS, V237, P353, DOI 10.1016/j.atherosclerosis.2014.09.015
   Neeland IJ, 2013, OBESITY, V21, pE439, DOI [10.1002/oby.20135, 10.1038/oby.20135]
   Nerlekar N, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.117.006379
   Oikawa M, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/483982
   Ozcicek A, 2017, ARCH MED SCI, V13, P118, DOI 10.5114/aoms.2015.50784
   Park SH, 2006, RADIOLOGY, V239, P105, DOI 10.1148/radiol.2391050361
   PIEKARSKI J, 1980, RADIOLOGY, V137, P727, DOI 10.1148/radiology.137.3.6934563
   Rabkin SW, 2014, METAB SYNDR RELAT D, V12, P31, DOI 10.1089/met.2013.0107
   Sarin S, 2008, AM J CARDIOL, V102, P767, DOI 10.1016/j.amjcard.2008.04.058
   Saritas T, 2020, CLIN KIDNEY J, V13, P571, DOI 10.1093/ckj/sfz030
   Silaghi A, 2008, OBESITY, V16, P2424, DOI 10.1038/oby.2008.379
   Smits MM, 2013, J GASTROEN HEPATOL, V28, P664, DOI 10.1111/jgh.12106
   Song DK, 2015, DIABETES METAB J, V39, P405, DOI 10.4093/dmj.2015.39.5.405
   Tomic D, 2018, EUR J GASTROEN HEPAT, V30, P1103, DOI 10.1097/MEG.0000000000001235
   Tonbul HZ, 2011, RENAL FAILURE, V33, P770, DOI 10.3109/0886022X.2011.599913
   Topuz M, 2014, INVESTIGATION RELATI
   Turan Y, 2020, ANGIOLOGY, V71, P77, DOI 10.1177/0003319719844933
   Turkmen K, 2013, INT UROL NEPHROL, V45, P857, DOI 10.1007/s11255-012-0286-x
   Versteylen MO, 2012, EUR HEART J-CARD IMG, V13, P517, DOI 10.1093/ehjci/jes024
   Wang TD, 2010, ATHEROSCLEROSIS, V213, P279, DOI 10.1016/j.atherosclerosis.2010.07.055
   Wang TD, 2009, J CLIN ENDOCR METAB, V94, P662, DOI 10.1210/jc.2008-0834
   Wilund KR, 2010, NEPHROL DIAL TRANSPL, V25, P2695, DOI 10.1093/ndt/gfq106
   Wu SQ, 2016, SCI REP-UK, V6, DOI 10.1038/srep33386
   Yerramasu A, 2012, ATHEROSCLEROSIS, V220, P223, DOI 10.1016/j.atherosclerosis.2011.09.041
   Zhou YY, 2018, EUR J GASTROEN HEPAT, V30, P631, DOI [10.1097/MEG.0000000000001075, 10.1097/meg.0000000000001075]
NR 60
TC 4
Z9 4
U1 0
U2 8
PU AVES
PI SISLI
PA BUYUKDERE CAD 105-9, MECIDIYEKOY, SISLI, ISTANBUL 34394, TURKEY
SN 2149-2263
EI 2149-2271
J9 ANATOL J CARDIOL
JI Anat. J. Cardiol.
PD OCT
PY 2022
VL 26
IS 10
BP 762
EP 770
DI 10.5152/AnatolJCardiol.2022.1787
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 6D2UQ
UT WOS:000882552600005
PM 35943316
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Mahbouli, S
   Dupont, C
   Elfassy, Y
   Lameignère, E
   Levy, R
AF Mahbouli, Sinda
   Dupont, Charlotte
   Elfassy, Yaelle
   Lameignere, Eric
   Levy, Rachel
TI Exploring the potential impact of nutritionally actionable genetic
   polymorphisms on idiopathic male infertility: a review of current
   evidence
SO ASIAN JOURNAL OF ANDROLOGY
LA English
DT Review
ID SPERM DNA-DAMAGE; OXIDATIVE STRESS; NITRIC-OXIDE; VITAMIN-D; METABOLIC
   SYNDROME; APOLIPOPROTEIN-E; SEMINAL PLASMA; SELENIUM SUPPLEMENTATION;
   COMMON VARIANTS; INCREASED RISK
AB Infertility affects about 15% of the world's population. In 40%-50% of infertile couples, a male factor underlies the problem, but in about 50% of these cases, the etiology of male infertility remains unexplained. Some clinical data show that lifestyle interventions may contribute to male reproductive health. Cessation of unhealthy habits is suggested for preserving male fertility; there is growing evidence that most preexisting comorbidities, such as obesity and metabolic syndrome, are highly likely to have an impact on male fertility. The analysis of genetic polymorphisms implicated in metabolic activity represents one of the most exciting areas in the study of genetic causes of male infertility. Although these polymorphisms are not directly connected with male infertility, they may have a role in specific conditions associated with it, that is, metabolic disorders and oxidative stress pathway genes that are potentially associated with an increased risk of male infertility due to DNA and cell membrane damage. Some studies have examined the impact of individual genetic differences and gene-diet interactions on male infertility, but their results have not been synthesized. We review the current research to identify genetic variants that could be tested to improve the chances of conceiving spontaneously through personalized diet and/or oral vitamin and mineral supplementation, by examining the science of genetic modifiers of dietary factors that affect nutritional status and male fertility.
C1 [Mahbouli, Sinda; Lameignere, Eric] FabLife, 104 Ave Albert 1er, F-92500 Rueil Malmaison, France.
   [Dupont, Charlotte; Levy, Rachel] Sorbonne Univ, Tenon Hosp, AP HP, St Antoine Res Ctr,INSERM,Genet & Acquired Lipody, F-75020 Paris, France.
   [Dupont, Charlotte; Elfassy, Yaelle; Levy, Rachel] Tenon Hosp, AP HP, Reprod Biol & CECOS, F-75020 Paris, France.
C3 Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital
   Universitaire Tenon - APHP; Hopital Universitaire Saint-Antoine - APHP;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital
   Universitaire Tenon - APHP
RP Levy, R (corresponding author), Sorbonne Univ, Tenon Hosp, AP HP, St Antoine Res Ctr,INSERM,Genet & Acquired Lipody, F-75020 Paris, France.; Levy, R (corresponding author), Tenon Hosp, AP HP, Reprod Biol & CECOS, F-75020 Paris, France.
EM rachel.levy@aphp.fr
RI Dupont, Charlotte/AAL-8780-2020
CR Agarwal A, 2006, UROLOGY, V67, P2, DOI 10.1016/j.urology.2005.07.012
   Aitken RJ, 2016, J ASSIST REPROD GEN, V33, P1691, DOI 10.1007/s10815-016-0791-4
   Aitken RJ, 2014, ASIAN J ANDROL, V16, P31, DOI 10.4103/1008-682X.122203
   Aston KI, 2010, HUM REPROD, V25, P1383, DOI 10.1093/humrep/deq081
   Balercia G, 2004, J ANDROL, V25, P245
   Bansal Amrit Kaur, 2010, Vet Med Int, V2010, DOI 10.4061/2011/686137
   Bhakat R, 2017, INDIAN J CLIN BIOCHE, V32, P468, DOI 10.1007/s12291-017-0632-y
   Brown KM, 2000, CLIN SCI, V98, P593, DOI 10.1042/CS19990276
   Buldreghini E, 2010, J ANDROL, V31, P482, DOI 10.2164/jandrol.109.008979
   Cahill LE, 2009, AM J CLIN NUTR, V90, P1411, DOI 10.3945/ajcn.2009.28327
   Chan D, 2010, ENDOCRINOLOGY, V151, P3363, DOI 10.1210/en.2009-1340
   Chavarro JE, 2010, FERTIL STERIL, V93, P2222, DOI 10.1016/j.fertnstert.2009.01.100
   Connor KL, 2012, J PHYSIOL-LONDON, V590, P2167, DOI 10.1113/jphysiol.2011.223305
   Conquer JA, 2000, LIPIDS, V35, P149, DOI 10.1007/BF02664764
   Corbo RM, 2004, FERTIL STERIL, V81, P104, DOI 10.1016/j.fertnstert.2003.05.029
   de Angelis C, 2017, REV ENDOCR METAB DIS, V18, P285, DOI 10.1007/s11154-017-9425-0
   Ding W, 2018, BMC MED GENET, V19, DOI 10.1186/s12881-018-0553-5
   Dupont C, 2013, ASIAN J ANDROL, V15, P622, DOI 10.1038/aja.2013.65
   Dupont J, 2015, HORM MOL BIOL CLIN I, V24, P11, DOI 10.1515/hmbci-2015-0034
   Ebisch IMW, 2007, HUM REPROD UPDATE, V13, P163, DOI 10.1093/humupd/dml054
   Ergün A, 2007, ARCH ANDROLOGY, V53, P21, DOI 10.1080/01485010600888961
   Fenech M, 2001, MUTAT RES-FUND MOL M, V475, P1, DOI 10.1016/S0027-5107(01)00069-0
   Finkelstein JD, 2000, SEMIN THROMB HEMOST, V26, P219, DOI 10.1055/s-2000-8466
   Gameiro S, 2016, HUM REPROD, V31, P1928, DOI 10.1093/humrep/dew155
   Rodríguez AG, 2019, ANN HUM GENET, V83, P63, DOI 10.1111/ahg.12286
   García-Martín E, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0065487
   Gattas GJF, 2004, BRAZ J MED BIOL RES, V37, P451, DOI 10.1590/S0100-879X2004000400002
   Gava MM, 2011, GENET TEST MOL BIOMA, V15, P153, DOI 10.1089/gtmb.2010.0128
   Gharagozloo P, 2011, HUM REPROD, V26, P1628, DOI 10.1093/humrep/der132
   Giahi L, 2016, NUTR REV, V74, P118, DOI 10.1093/nutrit/nuv059
   Gong MC, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0121147
   Gunes S, 2016, J ASSIST REPROD GEN, V33, P553, DOI 10.1007/s10815-016-0682-8
   Håkonsen LB, 2011, REPROD HEALTH, V8, DOI 10.1186/1742-4755-8-24
   Hamade A., 2014, Universal Journal of Public Health, P118, DOI [10.13189/ujph.2014.020402, DOI 10.13189/UJPH.2014.020402]
   Haussler MR, 2011, BEST PRACT RES CL EN, V25, P543, DOI 10.1016/j.beem.2011.05.010
   Herrero MB, 2001, J ANDROL, V22, P349
   Hinney A, 2013, PROG MOL BIOL TRANSL, V114, P147, DOI 10.1016/B978-0-12-386933-3.00005-4
   Hopewell JC, 2014, J INTERN MED, V276, P260, DOI 10.1111/joim.12187
   Horne J, 2018, LIFESTYLE GENOM, V11, P49, DOI 10.1159/000488086
   Hosseini B, 2015, GALEN MED J, V4, P123
   Huang I, 2006, MED SCI MONITOR, V12, pCR103
   Hunt SC, 2008, OBESITY, V16, P902, DOI 10.1038/oby.2007.126
   Ilacqua A, 2018, REPROD BIOL ENDOCRIN, V16, DOI 10.1186/s12958-018-0436-9
   Irfan M, 2016, BALK J MED GENET, V19, P51, DOI 10.1515/bjmg-2016-0007
   Jacques PF, 2001, AM J CLIN NUTR, V73, P613
   Ji GX, 2012, FREE RADICAL BIO MED, V52, P775, DOI 10.1016/j.freeradbiomed.2011.11.032
   Jia GF, 2011, NAT CHEM BIOL, V7, P885, DOI [10.1038/NCHEMBIO.687, 10.1038/nchembio.687]
   Johnson AR, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036047
   Kabisch S, 2019, J DIABETES COMPLICAT, V33, P193, DOI 10.1016/j.jdiacomp.2018.11.008
   Kao SH, 2008, FERTIL STERIL, V89, P1183, DOI 10.1016/j.fertnstert.2007.05.029
   Kasturi SS, 2008, J ANDROL, V29, P251, DOI 10.2164/jandrol.107.003731
   Katsoulis K, 2018, HORM-INT J ENDOCRINO, V17, P359, DOI 10.1007/s42000-018-0047-z
   Kaukua J, 2003, OBES RES, V11, P689, DOI 10.1038/oby.2003.98
   Kothari S, 2010, INDIAN J EXP BIOL, V48, P425
   Kumar N, 2018, J GYNECOL OBSTET HUM, V47, P565, DOI 10.1016/j.jogoh.2018.06.008
   La Vignera S, 2012, ANDROLOGIA, V44, P565, DOI 10.1111/j.1439-0272.2011.01228.x
   Landfors M, 2016, FERTIL STERIL, V105, P1170, DOI 10.1016/j.fertnstert.2016.01.002
   Lange CM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0064053
   Laqqan M, 2018, ANDROLOGIA, V50, DOI 10.1111/and.12913
   Lazaros L, 2012, ASIAN J ANDROL, V14, P778, DOI 10.1038/aja.2011.125
   Lazaros LA, 2011, J ANDROL, V32, P394, DOI 10.2164/jandrol.110.010348
   Levine H, 2017, HUM REPROD UPDATE, V23, P646, DOI 10.1093/humupd/dmx022
   Li HL, 2003, J MOL MED, V81, P766, DOI 10.1007/s00109-003-0481-4
   Li SS, 2014, GENET MOL RES, V13, P6367, DOI 10.4238/2014.March.24.26
   Liu K, 2015, SCI REP-UK, V5, DOI 10.1038/srep15548
   Liu XH, 2015, GENET MOL RES, V14, P16856, DOI 10.4238/2015.December.14.12
   Lobaccaro JMA, 2012, CLIN LIPIDOL, V7, P485, DOI 10.2217/CLP.12.58
   Loos RJF, 2008, NAT GENET, V40, P768, DOI 10.1038/ng.140
   Mahley RW, 2000, ANNU REV GENOM HUM G, V1, P507, DOI 10.1146/annurev.genom.1.1.507
   Major JM, 2011, HUM MOL GENET, V20, P3876, DOI 10.1093/hmg/ddr296
   Maqdasy S, 2013, MOL CELL ENDOCRINOL, V368, P30, DOI 10.1016/j.mce.2012.06.011
   Mendiola J, 2009, FERTIL STERIL, V91, P812, DOI 10.1016/j.fertnstert.2008.01.020
   Miller JC, 2012, AM J CLIN NUTR, V96, P923, DOI 10.3945/ajcn.112.043125
   Morrison CD, 2015, BEST PRACT RES CL OB, V29, P507, DOI 10.1016/j.bpobgyn.2014.10.006
   Mostafa T, 2015, ANDROLOGIA, V47, P209, DOI 10.1111/and.12248
   Murphy LE, 2011, ASIAN J ANDROL, V13, P856, DOI 10.1038/aja.2011.96
   Ng SF, 2010, NATURE, V467, P963, DOI 10.1038/nature09491
   Olthof MR, 2003, J NUTR, V133, P4135, DOI 10.1093/jn/133.12.4135
   Ordovas J M, 1999, Curr Atheroscler Rep, V1, P196, DOI 10.1007/s11883-999-0032-8
   Palmer Nicole O, 2012, Spermatogenesis, V2, P253
   Paracchini V, 2006, BIOMARKERS, V11, P53, DOI 10.1080/13547500500442050
   Ramirez-Torres M A, 2000, Ginecol Obstet Mex, V68, P224
   Ren BN, 2019, ANN HUM GENET, V83, P434, DOI 10.1111/ahg.12326
   Sabouhi S, 2015, ANDROLOGIA, V47, P97, DOI 10.1111/and.12228
   Safarinejad MR, 2011, ANDROLOGIA, V43, P38, DOI 10.1111/j.1439-0272.2009.01013.x
   Safarinejad MR, 2012, UROL J, V9, P541
   Safarinejad MR, 2010, MOL REPROD DEV, V77, P720, DOI 10.1002/mrd.21210
   Saleh RA, 2003, FERTIL STERIL, V79, P1597, DOI 10.1016/S0015-0282(03)00337-6
   Salehi Z, 2012, REPROD SCI, V19, P81, DOI 10.1177/1933719111413302
   Santi D, 2017, ANDROLOGY-US, V5, P695, DOI 10.1111/andr.12379
   Schisterman EF, 2014, J CLIN ENDOCR METAB, V99, P2786, DOI 10.1210/jc.2013-3936
   Sermondade N, 2013, HUM REPROD UPDATE, V19, P221, DOI 10.1093/humupd/dms050
   Sermondade N, 2012, ARCH INTERN MED, V172, P440, DOI 10.1001/archinternmed.2011.1382
   Setarehbadi R, 2012, SYST BIOL REPROD MED, V58, P263, DOI 10.3109/19396368.2012.684134
   Shelnutt KP, 2003, J NUTR, V133, P4107, DOI 10.1093/jn/133.12.4107
   Shi TL, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000014283
   Shiva M, 2011, CLIN BIOCHEM, V44, P319, DOI 10.1016/j.clinbiochem.2010.11.009
   Smits RM, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007411.pub4
   Soubry A, 2018, ENVIRON EPIGENETICS, V4, DOI 10.1093/eep/dvy007
   Steenge GR, 2003, J NUTR, V133, P1291
   Sunden SLF, 1997, ARCH BIOCHEM BIOPHYS, V345, P171, DOI 10.1006/abbi.1997.0246
   Tang QQ, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-11636-9
   Tavilani H, 2014, SYST BIOL REPROD MED, V60, P361, DOI 10.3109/19396368.2014.960624
   Tüttelmann F, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019426
   Venkatesh S, 2011, INDIAN J MED RES, V134, P396
   Verit FF, 2009, J ANDROL, V30, P183, DOI 10.2164/jandrol.108.004929
   Vladoiu S, 2016, ACTA ENDOCRINOL-BUCH, V12, P137, DOI 10.4183/aeb.2016.137
   Vucic NLJ, 2018, ANDROLOGIA, V50, DOI 10.1111/and.12817
   Wan L, 2018, TRANSL PSYCHIAT, V8, DOI 10.1038/s41398-018-0276-6
   Watkins D, 2002, AM J HUM GENET, V71, P143, DOI 10.1086/341354
   Wu CY, 2012, J ASSIST REPROD GEN, V29, P837, DOI 10.1007/s10815-012-9790-2
   Wu W, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013884
   Xiong DK, 2015, ASIAN J ANDROL, V17, P481, DOI 10.4103/1008-682X.143737
   Xue G, 2017, ONCOTARGET, V8, P51387, DOI 10.18632/oncotarget.17988
   Yan LF, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0115190
   Zanatta L, 2011, LIFE SCI, V89, P515, DOI 10.1016/j.lfs.2011.04.008
   Zhang MZ, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0133788
   Zhu Pei-Ran, 2017, Zhonghua Nan Ke Xue, V23, P137
NR 118
TC 3
Z9 5
U1 0
U2 6
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 1008-682X
EI 1745-7262
J9 ASIAN J ANDROL
JI Asian J. Androl.
PD SEP-OCT
PY 2021
VL 23
IS 5
BP 441
EP 449
DI 10.4103/aja.aja_87_20
PG 9
WC Andrology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Urology & Nephrology
GA WQ9SM
UT WOS:000714150100001
PM 33533736
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Danciu, AM
   Ghitea, TC
   Bungau, AF
   Vesa, CM
AF Danciu, Adrian Marius
   Ghitea, Timea Claudia
   Bungau, Alexa Florina
   Vesa, Cosmin Mihai
TI The Crucial Role of Diet Therapy and Selenium on the Evolution of
   Clinical and Paraclinical Parameters in Patients with Metabolic Syndrome
SO JOURNAL OF NUTRITION AND METABOLISM
LA English
DT Article
ID OXIDATIVE STRESS; ACNE-VULGARIS; MUSCLE STRENGTH; PATHOGENESIS;
   ANTIOXIDANTS; INFLAMMATION; INVOLVEMENT; QUALITY; ADULTS
AB Oxidative stress (OS) is associated with metabolic syndrome (MS) and represents a complex disease association that has become a major challenge in the field of public health. The aim of this study was to investigate the effectiveness of introducing selenium in the management of OS, while considering a balanced diet based on a healthy lifestyle and dietary therapy. A total of 206 individuals participated voluntarily in the study, divided into three groups: the control group with 35 individuals (17.0%) designated as control lot (LC), the group undergoing diet therapy with 119 individuals (57.8%) designated as diet therapy lot (LD), and the group undergoing diet therapy supplemented with selenium consisting of 52 individuals (25.2%) designated as diet therapy with selenium lot (LD + Se). The study assessed various clinical parameters (such as body mass index (BMI), body weight status, fat mass, visceral fat, and sarcopenic index), paraclinical parameters (including HOMA index, cholesterol, triglycerides, C-reactive protein, and glycosylated haemoglobin (HGS)), as well as OS parameters (measured using the FORD test, FORT test, and MIXED test). The LD + Se group demonstrated the most favourable results in terms of BMI reduction, decreased fat and visceral mass, reduced levels of C-reactive protein, and improved glycosylated haemoglobin levels. By implementing a balanced diet therapy and supplementing the diet with selenium, it was possible to achieve a reduction in adipose tissue and glycosylated haemoglobin levels, ultimately contributing to the reduction of OS in the body.
C1 [Danciu, Adrian Marius; Bungau, Alexa Florina] Univ Oradea, Doctoral Sch Biol & Biomed Sci, Oradea 410087, Romania.
   [Ghitea, Timea Claudia] Univ Oradea, Fac Med & Pharm, Pharm Dept, Oradea 410068, Romania.
   [Vesa, Cosmin Mihai] Univ Oradea, Fac Med & Pharm, Med Dept, Oradea 410068, Romania.
C3 University of Oradea; University of Oradea; University of Oradea
RP Bungau, AF (corresponding author), Univ Oradea, Doctoral Sch Biol & Biomed Sci, Oradea 410087, Romania.; Ghitea, TC (corresponding author), Univ Oradea, Fac Med & Pharm, Pharm Dept, Oradea 410068, Romania.
EM adrian.danciu@telios.ro; timea.ghitea@csud.uoradea.ro;
   pradaalexaflorina@gmail.com; v_cosmin_15@yahoo.com
RI Mihai, Vesa/AAE-5495-2019; Bungau, Alexa/AGY-4752-2022; Ghitea, Timea
   Claudia/AAJ-4273-2021
OI Cosmin Mihai, Vesa/0000-0001-5071-9601; Ghitea, Timea
   Claudia/0000-0001-8981-1958
FU The authors would like to thank the University of Oradea for supporting
   the payment of the invoice, through an internal project. The APC was
   funded by the University of Oradea, Oradea, Romania.; University of
   Oradea - University of Oradea; Oradea, Romania
FX The authors would like to thank the University of Oradea for supporting
   the payment of the invoice, through an internal project. The APC was
   funded by the University of Oradea, Oradea, Romania.
CR Abdel-Daim MM, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/6276438
   Akamatsu H, 2003, INT J DERMATOL, V42, P366, DOI 10.1046/j.1365-4362.2003.01540.x
   Al-Shobaili HA, 2014, ANN CLIN LAB SCI, V44, P202
   Allhorn M, 2003, J INVEST DERMATOL, V121, P640, DOI 10.1046/j.1523-1747.2003.12409.x
   Barchielli G, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11020251
   Bickers DR, 2006, J INVEST DERMATOL, V126, P2565, DOI 10.1038/sj.jid.5700340
   Boissy RE, 2004, PIGM CELL RES, V17, P208, DOI 10.1111/j.1600-0749.2004.00130.x
   Bonomini F, 2015, AGING DIS, V6, P109, DOI 10.14336/AD.2014.0305
   Bungau S, 2020, EXP THER MED, V20, DOI 10.3892/etm.2020.9327
   Zaha DC, 2020, EXP THER MED, V20, P121, DOI 10.3892/etm.2020.8663
   COHEN J, 1992, PSYCHOL BULL, V112, P155, DOI 10.1037/0033-2909.112.1.155
   Cordain L, 2002, ARCH DERMATOL, V138, P1584, DOI 10.1001/archderm.138.12.1584
   Costa A, 2010, AN BRAS DERMATOL, V85, P346, DOI 10.1590/S0365-05962010000300008
   Couillard C, 2005, J CLIN ENDOCR METAB, V90, P6454, DOI 10.1210/jc.2004-2438
   Del Rio D, 2005, NUTR METAB CARDIOVAS, V15, P316, DOI 10.1016/j.numecd.2005.05.003
   Esterbauer H, 1996, PATHOL BIOL, V44, P25
   FRANCIS GL, 1988, BIOCHEM J, V251, P95, DOI 10.1042/bj2510095
   Gavra DI, 2022, MOLECULES, V27, DOI 10.3390/molecules27175499
   Ghitea TC, 2020, ACTA ENDOCRINOL-BUCH, V16, P470, DOI 10.4183/aeb.2020.470
   Guillin OM, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092101
   Guyatt GH, 2008, BRIT MED J, V336, P924, DOI 10.1136/bmj.39489.470347.AD
   Hariharan S, 2020, INFLAMMOPHARMACOLOGY, V28, P667, DOI 10.1007/s10787-020-00690-x
   Hosny NS, 2020, FRONT VET SCI, V7, DOI 10.3389/fvets.2020.00290
   Jennings A, 2020, AM J CLIN NUTR, V111, P98, DOI 10.1093/ajcn/nqz243
   Jichitu A, 2021, DIAGNOSTICS, V11, DOI 10.3390/diagnostics11040689
   Jurca MC, 2018, ROM J MORPHOL EMBRYO, V59, P381
   Kanfer S., 1981, Oxygen and Living Processes, P47
   Kardeh S, 2014, EUR J PHARMACOL, V735, P150, DOI 10.1016/j.ejphar.2014.04.023
   Keshavarz-Rezaei M, 2022, BIOMATER ADV, V140, DOI 10.1016/j.bioadv.2022.213084
   Kidd Parris, 2003, Altern Med Rev, V8, P223
   Kircik LH, 2014, J DRUGS DERMATOL, V13, pS56
   Lauretani F, 2007, AM J CLIN NUTR, V86, P347, DOI 10.1093/ajcn/86.2.347
   Lewis NA, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0149927
   Mehdi Y, 2013, MOLECULES, V18, P3292, DOI 10.3390/molecules18033292
   Melnik BC, 2018, CLIN DERMATOL, V36, P29, DOI 10.1016/j.clindermatol.2017.09.006
   Melnik BC, 2009, MED HYPOTHESES, V72, P631, DOI 10.1016/j.mehy.2009.01.008
   Merkel M, 2002, J BIOL CHEM, V277, P7405, DOI 10.1074/jbc.M107914200
   Mills Otto H, 2016, J Clin Aesthet Dermatol, V9, P25
   Millward DJ, 2008, AM J CLIN NUTR, V87, p1576S, DOI 10.1093/ajcn/87.5.1576S
   Mistry HD, 2012, AM J OBSTET GYNECOL, V206, P21, DOI 10.1016/j.ajog.2011.07.034
   Monteiro R, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/289645
   Murphy MP, 2018, NAT REV DRUG DISCOV, V17, P865, DOI 10.1038/nrd.2018.174
   Nyska A, 2002, TOXICOL PATHOL, V30, P620, DOI 10.1080/01926230290166724
   Palmieri VO, 2006, J NUTR, V136, P3022, DOI 10.1093/jn/136.12.3022
   Papaccio F, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11061121
   Parthasarathy S, 2010, METHODS MOL BIOL, V610, P403, DOI 10.1007/978-1-60327-029-8_24
   Pavlatou MG, 2009, METABOLISM, V58, P1657, DOI 10.1016/j.metabol.2009.05.022
   Penso L, 2020, JAMA DERMATOL, V156, P854, DOI 10.1001/jamadermatol.2020.1602
   Pinzani M, 1998, LIVER, V18, P2
   Random O. R. G, 1998, What's this fuss about true randomness
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   Popa AR, 2020, EXP THER MED, V20, P129, DOI 10.3892/etm.2020.8662
   Rezzani R, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020301
   Riley J., 2009, Journal of the American Academy of Dermatology, V60, P19, DOI [10.1016/j.jaad.2008.11.108, DOI 10.1016/J.JAAD.2008.11.108]
   Rotariu D, 2022, BIOMED PHARMACOTHER, V152, DOI 10.1016/j.biopha.2022.113238
   Sharifi-Rad M, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.00694
   Singh A, 2019, MOLECULES, V24, DOI 10.3390/molecules24081583
   Sivonová M, 2004, STRESS, V7, P183, DOI 10.1080/10253890400012685
   SUTHANTHIRAN M, 1990, P NATL ACAD SCI USA, V87, P3343, DOI 10.1073/pnas.87.9.3343
   Tanianskii DA, 2019, NUTRIENTS, V11, DOI 10.3390/nu11030524
   Terzo S, 2018, NUTRIENTS, V10, DOI 10.3390/nu10121857
   Tieu K, 2003, IUBMB LIFE, V55, P329, DOI 10.1080/1521654032000114320
   Tomaipitinca L, 2019, NUTRIENTS, V11, DOI 10.3390/nu11040827
   Trichopoulou A, 1997, NUTR REV, V55, P383, DOI 10.1111/j.1753-4887.1997.tb01578.x
   Trifan DF, 2023, HEALTHCARE-BASEL, V11, DOI 10.3390/healthcare11101490
   Ferreira RLU, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.685317
   van Dronkelaar C, 2018, J AM MED DIR ASSOC, V19, P6, DOI 10.1016/j.jamda.2017.05.026
   Venditti P, 2013, MITOCHONDRION, V13, P71, DOI 10.1016/j.mito.2013.01.008
   Vincent HK, 2006, INT J OBESITY, V30, P400, DOI 10.1038/sj.ijo.0803177
   WEBSTER GF, 1995, J AM ACAD DERMATOL, V33, P247, DOI 10.1016/0190-9622(95)90243-0
   Yang JH, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010114
   Zheng YH, 2022, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.820853
   Zhenyukh O, 2017, FREE RADICAL BIO MED, V104, P165, DOI 10.1016/j.freeradbiomed.2017.01.009
NR 73
TC 2
Z9 2
U1 2
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2090-0724
EI 2090-0732
J9 J NUTR METAB
JI J. Nutr. Metab.
PD SEP 25
PY 2023
VL 2023
AR 6632197
DI 10.1155/2023/6632197
PG 14
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA T3XS0
UT WOS:001077355200001
PM 37790730
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Francisqueti-Ferron, FV
   Silva, JPD
   Garcia, JL
   Ferron, AJT
   Kano, HT
   Silva, CCVD
   Costa, MR
   Nai, GA
   Moreto, F
   Corrêa, CR
AF Francisqueti-Ferron, Fabiane Valentini
   Silva, Janaina Paixao das Chagas
   Garcia, Jessica Leite
   Ferron, Artur Junio Togneri
   Kano, Hugo Tadashi
   Silva, Carol Cristina Vagula de Almeida
   Costa, Mariane Rovero
   Nai, Gisele Alborghetti
   Moreto, Fernando
   Correa, Camila Renata
TI Preventive Effect of Gamma-Oryzanol on Physiopathological Process
   Related to Nonalcoholic Fatty Liver Disease in Animals Submitted to High
   Sugar/Fat Diet
SO LIVERS
LA English
DT Article
DE nonalcoholic fatty liver disease; gamma-oryzanol; metabolic syndrome;
   bioactive compounds
AB Nonalcoholic fatty liver disease (NAFLD) is the main cause of liver disease. The physiopathological processes involved in the disease are metabolic syndrome (MetS) components (central obesity, dyslipidemia, insulin resistance/type 2 diabetes, hypertension), genetic, and dietary factors, including unsaturated fats and sweetened beverages, which are able to lead to inflammation and oxidative stress, conditions associated with progression and severity of NAFLD. Gamma-oryzanol (gamma Oz) is a nutraceutical obtained from rice brain oil with many benefits to health, from immunological to metabolic. The aim of this study is to test the preventive effect of gamma Oz on the physiopathological process related to nonalcoholic fatty liver disease in animals submitted to high sugar/fat diet. Male Wistar rats (+/- 187 g) were randomly divided into four experimental groups to receive: control diet (C, n = 6), control diet plus gamma Oz (C + gamma Oz, n = 6), high sugar/fat diet (HSF, n = 6), or high sugar/fat diet plus gamma Oz (HSF + gamma Oz, n = 6) during 30 weeks. HSF groups also received water plus sucrose (25%). gamma Oz was added to diets to reach 0.5% of final concentration. The HSF group presented MetS, liver inflammation and oxidative stress, and micro and macrovesicular steatosis. HSF plus gamma Oz was protected against these changes. It is possible to conclude that gamma-oryzanol was effective in modulating the physiopathological process related to nonalcoholic fatty liver disease in animals submitted to a high sugar/fat diet.
C1 [Francisqueti-Ferron, Fabiane Valentini; Garcia, Jessica Leite; Ferron, Artur Junio Togneri; Kano, Hugo Tadashi; Silva, Carol Cristina Vagula de Almeida; Costa, Mariane Rovero; Moreto, Fernando; Correa, Camila Renata] Sao Paulo State Univ UNESP, Med Sch, BR-18618687 Botucatu, SP, Brazil.
   [Silva, Janaina Paixao das Chagas] Sao Paulo State Univ UNESP, Inst Biosci, BR-18618687 Botucatu, SP, Brazil.
   [Nai, Gisele Alborghetti] Univ Oeste Paulista UNOESTE, Dept Pathol Anat & Cytopathol, BR-19050680 Presidente Prudente, SP, Brazil.
C3 Universidade Estadual Paulista; Universidade Estadual Paulista;
   Universidade do Oeste Paulista
RP Francisqueti-Ferron, FV (corresponding author), Sao Paulo State Univ UNESP, Med Sch, BR-18618687 Botucatu, SP, Brazil.
EM fabiane_vf@yahoo.com.br
RI Nai, Gisele/G-6810-2012; Correa, Camila/Q-2071-2019; Francisqueti-
   Ferron, Fabiane/M-4919-2017; Leite Garcia, Jessica/Q-8779-2018; Moreto,
   Fernando/I-7690-2013; Ferron, Artur Junio/M-5194-2017
OI Nai, Gisele/0000-0003-1674-7371; Vagula de Almeida Silva, Carol
   Cristina/0000-0001-9911-6254; Correa, Camila Renata/0000-0001-8493-5329;
   Kano, Hugo Tadashi/0000-0003-3938-4921; Francisqueti- Ferron,
   Fabiane/0000-0003-2910-4308; Leite Garcia, Jessica/0000-0002-3670-243X;
   Moreto, Fernando/0000-0002-4028-0014; Ferron, Artur
   Junio/0000-0001-7089-3033
FU Sao Paulo Research Foundation (FAPESP) [2015/10626-0, 2019/04524-0]
FX Sao Paulo Research Foundation (FAPESP), grant #2015/10626-0 and
   #2019/04524-0
CR [Anonymous], 2013, World J Hypertens, DOI 10.5494/wjh.v3.i3.18
   Buzzetti E, 2016, METABOLISM, V65, P1038, DOI 10.1016/j.metabol.2015.12.012
   Caturano A, 2021, PROCESSES, V9, DOI 10.3390/pr9010135
   Costa MR, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8080276
   Francisqueti FV, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/1278392
   Francisqueti FV, 2017, NUTRIENTS, V9, DOI 10.3390/nu9121299
   Francisqueti-Ferron FV, 2021, MOL CELL ENDOCRINOL, V520, DOI 10.1016/j.mce.2020.111095
   Freitas I, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/9307064
   Gao B, 2016, GASTROENTEROLOGY, V150, P1704, DOI 10.1053/j.gastro.2016.01.025
   IBGE Instituto Brasileiro de Geografia e Estatistica Coordenacao de Trabalho e Rendimento, Pesquisa de Orcamentos Familiares: 2008-2009. Analise Do Consumo Aliment
   Jung CH, 2015, NUTRIENTS, V7, P4851, DOI 10.3390/nu7064851
   Kalra A., 2022, Physiology (Liver)
   Lafontan M, 2014, DIABETES METAB, V40, P16, DOI 10.1016/j.diabet.2013.08.002
   Liang W, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0115922
   Justo ML, 2016, EUR J NUTR, V55, P2011, DOI 10.1007/s00394-015-1015-x
   Ma ZH, 2017, SCI REP-UK, V7, DOI 10.1038/srep44819
   Masarone M, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/9547613
   Mattei L, 2021, MOL CELL ENDOCRINOL, V537, DOI 10.1016/j.mce.2021.111423
   Mesquita CS, 2014, ANAL BIOCHEM, V458, P69, DOI 10.1016/j.ab.2014.04.034
   Minatel IO, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17081107
   Monteiro R, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/289645
   Nd Asia Muhammad, 2019, Integr Med (Encinitas), V18, P42
   Parra-Vargas M, 2018, NUTRIENTS, V10, DOI 10.3390/nu10081060
   Ruiz-Ojeda FJ., 2018, Obesity, P1, DOI [DOI 10.1016/B978-0-12-812504-5.00001-5, 10.1016/b978-0-12-812504-5.00001-5]
   Samarghandian S, 2016, BIOCHEM RES INT, V2016, DOI 10.1155/2016/2645237
   Son MJ, 2011, J FOOD SCI, V76, pH7, DOI 10.1111/j.1750-3841.2010.01907.x
   Sulaiman A., 2021, Funct FoodsPhytochem Heal Promot Potential, P97666, DOI [10.5772/intechopen.97666, DOI 10.5772/INTECHOPEN.97666]
   Tomic D, 2018, EUR J GASTROEN HEPAT, V30, P1103, DOI 10.1097/MEG.0000000000001235
   Valenzuela R, 2018, PHARMACOL RES, V132, P168, DOI 10.1016/j.phrs.2017.12.013
   Wang O, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0118135
   WHO, 2016, World Health Organisation Obesity and Overweight Fact Sheet, VVolume 1
NR 31
TC 4
Z9 4
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2673-4389
J9 LIVERS-BASEL
JI Livers
PD SEP
PY 2022
VL 2
IS 3
BP 146
EP 157
DI 10.3390/livers2030013
PG 12
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA WI4E4
UT WOS:001254219500001
OA gold
DA 2025-06-11
ER

PT J
AU Ghosh, S
   Dhar, S
   Bhattacharjee, S
   Bhattacharjee, P
AF Ghosh, Sunandini
   Dhar, Shrinjana
   Bhattacharjee, Sandip
   Bhattacharjee, Pritha
TI Contribution of environmental, genetic and epigenetic factors to
   obesity-related metabolic syndrome
SO NUCLEUS-INDIA
LA English
DT Review
DE Non-communicable diseases; Lifestyle; Environmental factors; Obesity;
   Genetics; Epigenetics
ID BODY-MASS INDEX; RENIN-ANGIOTENSIN SYSTEM; CORONARY-HEART-DISEASE;
   FOOD-INTAKE REGULATION; DNA METHYLATION; PHYSICAL-ACTIVITY;
   INSULIN-RESISTANCE; HIGH-FAT; ADIPOSE-TISSUE; WEIGHT-GAIN
AB Non-communicable lifestyle diseases and related mortality are increasing rapidly over the last few decades. Obesity is one of the major concerning problems leading to obesity-related metabolic syndrome like cardiovascular diseases, type 2 diabetes mellitus, polycystic ovarian syndrome etc. About 40-75% of obesity cases arise through genetic inheritance. The genetic and epigenetic alterations involved in the disease manifestation are controlled by the environmental factors including both physical and physiological factors. In both the prenatal and postnatal stages of the concerned individual, the epigenetic modifications are controlled by the environmental factors subsequently leading to genomic alterations and predisposition of a disease. In this review, we have assimilated the studies from last 20 years discussing the genetic and epigenetic mechanisms of the predominant non-communicable diseases and the environmental factors affecting them. This review also focuses on the inter-relationship of the concerned environmental factors and their variations in a disease specific pattern. The environmental factors including diet, physical inactivity, stress, education, pollutants, addictions etc. have been found to portray significant role in the disease outcomes. The family income, exposure to heavy metal pollutants, noise pollution, endocrine disruptors and external stress inducing agents can't be controlled by the subject. Instead, controlling the diet pattern, family health, sleeping duration, screen time, addiction of alcohol or smoking and physical activity can provide significant benefit henceforth lowering the risk of obesity, CVD, T2DM and PCOD.
C1 [Ghosh, Sunandini; Dhar, Shrinjana; Bhattacharjee, Pritha] Univ Calcutta, Dept Environm Sci, Environm Epigen Lab, 35 Ballygunge Circular Rd, Kolkata 700019, West Bengal, India.
   [Ghosh, Sunandini] Univ Calcutta, Dept Zool, 35 Ballygunge Circular Rd, Kolkata 700019, India.
   [Bhattacharjee, Sandip] Siemens India, Hlth Management Environm Hlth & Safety, Level 21,Plot 1080,Dr Annie Besant Rd, Mumbai 400030, India.
C3 University of Calcutta; University of Calcutta
RP Bhattacharjee, P (corresponding author), Univ Calcutta, Dept Environm Sci, Environm Epigen Lab, 35 Ballygunge Circular Rd, Kolkata 700019, West Bengal, India.
EM 777.pritha@gmail.com
RI Dhar, Shrinjana/MTA-3614-2025; bhattacharjee, pritha/I-5171-2019
OI Bhattacharjee, Pritha/0000-0002-4623-7746; Dhar,
   Shrinjana/0000-0002-2765-0439
CR Abifadel M, 2003, NAT GENET, V34, P154, DOI 10.1038/ng1161
   Gnanadass SA, 2021, ARCH GYNECOL OBSTET, V303, P631, DOI 10.1007/s00404-020-05951-2
   Abumrad NA, 2016, BBA-MOL CELL BIOL L, V1861, P1442, DOI 10.1016/j.bbalip.2016.03.015
   Acker CI, 2012, CHEMOSPHERE, V89, P602, DOI 10.1016/j.chemosphere.2012.05.059
   Ahmadi Afsane, 2013, Indian J Endocrinol Metab, V17, P672, DOI 10.4103/2230-8210.113759
   Ajmal N, 2019, EUR J OBSTET GYN R B, V3, DOI 10.1016/j.eurox.2019.100060
   Akbari M, 2020, INFLAMMOPHARMACOLOGY, V28, P345, DOI 10.1007/s10787-019-00663-9
   Akinyemiju T, 2017, JAMA ONCOL, V3, P1683, DOI 10.1001/jamaoncol.2017.3055
   Alanbay I, 2012, ARCH GYNECOL OBSTET, V286, P1065, DOI 10.1007/s00404-012-2425-0
   An R, 2018, OBES REV, V19, P150, DOI 10.1111/obr.12624
   An RP, 2018, INT J OBESITY, V42, P1112, DOI 10.1038/s41366-018-0089-y
   Anbalagan Muralidharan, 2012, Nucl Recept Signal, V10, pe001, DOI 10.1621/nrs.10001
   Andrade Ana M, 2012, Int J Behav Nutr Phys Act, V9, P135, DOI 10.1186/1479-5868-9-135
   [Anonymous], 2016, World Health Organisation, Global Information System on Alcohol and Health (GISAH)
   Anyanwu GE, 2010, N AM J MED SCI, V2, P320, DOI 10.4297/najms.2010.2320
   Appelman MD, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.729828
   Aronica L, 2017, EPIGENOMICS-UK, V9, P769, DOI 10.2217/epi-2016-0182
   Aroor Annayya R, 2013, Front Endocrinol (Lausanne), V4, P161, DOI 10.3389/fendo.2013.00161
   Asante EO, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2019-035010
   Audrain-McGovern J, 2011, CLIN PHARMACOL THER, V90, P164, DOI 10.1038/clpt.2011.105
   Aye ILMH, 2022, J CLIN ENDOCR METAB, V107, P53, DOI 10.1210/clinem/dgab680
   Barnard K, 2013, DIABETES CARE, V36, P3337, DOI 10.2337/dc13-0560
   Battineni G, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22094798
   Bayoglu B, 2016, CLIN BIOCHEM, V49, P821, DOI 10.1016/j.clinbiochem.2016.02.012
   Bell CG, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0014040
   Benton MC, 2015, GENOME BIOL, V16, DOI 10.1186/s13059-014-0569-x
   Besar Dwi Sakti Berlian, 2020, Indonesian Journal of Medicine, V5, P38, DOI 10.26911/theijmed.2020.05.01.06
   Bhatnagar A, 2017, CIRC RES, V121, P162, DOI 10.1161/CIRCRESAHA.117.306458
   Bi HS, 2015, PUBLIC HEALTH NUTR, V18, P3013, DOI 10.1017/S1368980015000257
   Bird Y, 2015, INT J EQUITY HEALTH, V14, DOI 10.1186/s12939-015-0237-0
   Bisaccia G, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22020614
   Bloom MS, 2016, FERTIL STERIL, V106, P857, DOI 10.1016/j.fertnstert.2016.08.021
   Bogdarina I, 2007, CIRC RES, V100, P520, DOI 10.1161/01.RES.0000258855.60637.58
   Bonilla D., 2018, EC NUTR, V13, P4
   Booth FW, 2007, PHYSIOL GENOMICS, V28, P146, DOI 10.1152/physiolgenomics.00174.2006
   Bordoni L, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/9171684
   Bravard A, 2014, CELL COMMUN SIGNAL, V12, DOI 10.1186/1478-811X-12-4
   Brons C, 2010, J CLIN ENDOCR METAB, V95, P3048, DOI 10.1210/jc.2009-2413
   Brown JM, 2014, CIRCULATION, V129, P1799, DOI 10.1161/CIRCULATIONAHA.114.009224
   Cai R, 2015, J MOL CELL CARDIOL, V79, P115, DOI 10.1016/j.yjmcc.2014.11.014
   Carley AN, 2011, J BIOL CHEM, V286, P4589, DOI 10.1074/jbc.M110.182162
   Catalán V, 2022, NUTRIENTS, V14, DOI 10.3390/nu14081597
   Chiurazzi M, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21239035
   Choi Kangduk, 2010, Korean Journal of Internal Medicine, V25, P119, DOI 10.3904/kjim.2010.25.2.119
   Choquet H, 2011, CURR GENOMICS, V12, P169, DOI 10.2174/138920211795677895
   Chow JH, 2018, A A PRACT, V11, P175, DOI 10.1213/XAA.0000000000000775
   Comas-Armangue G, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10102461
   Cox AJ, 2015, LANCET DIABETES ENDO, V3, P207, DOI 10.1016/S2213-8587(14)70134-2
   Cristancho AG, 2011, NAT REV MOL CELL BIO, V12, P722, DOI 10.1038/nrm3198
   Cunningham AL, 2021, LIPIDS HEALTH DIS, V20, DOI 10.1186/s12944-021-01491-z
   Czajka M, 2019, ENVIRON RES, V178, DOI 10.1016/j.envres.2019.108685
   Darbre PD, 2018, INT J GEN MED, V11, P191, DOI 10.2147/IJGM.S102230
   De Silva K, 2022, HELIYON, V8, DOI 10.1016/j.heliyon.2022.e08886
   DeFuria J, 2013, P NATL ACAD SCI USA, V110, P5133, DOI 10.1073/pnas.1215840110
   den Biggelaar LJCJ, 2019, EUR J NUTR, V58, P597, DOI 10.1007/s00394-018-1644-y
   Dick KJ, 2014, LANCET, V383, P1990, DOI 10.1016/S0140-6736(13)62674-4
   Dludla PV, 2019, NUTRIENTS, V11, DOI 10.3390/nu11010023
   Doche ME, 2012, J CLIN INVEST, V122, P4732, DOI 10.1172/JCI62696
   Drummond EM, 2013, CURR OPIN CLIN NUTR, V16, P392, DOI 10.1097/MCO.0b013e3283620f45
   Dubern B, 2007, J PEDIATR-US, V150, P613, DOI 10.1016/j.jpeds.2007.01.041
   Duleba AJ, 2012, FERTIL STERIL, V97, P7, DOI 10.1016/j.fertnstert.2011.11.023
   Dzhambov AM, 2017, NOISE HEALTH, V19, P270, DOI 10.4103/nah.NAH_78_16
   Eleftheriadou M, 2012, J PEDIATR ADOL GYNEC, V25, P172, DOI 10.1016/j.jpag.2011.11.009
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   Fan HQ, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0127705
   Farooqi IS, 2007, NEW ENGL J MED, V356, P237, DOI 10.1056/NEJMoa063988
   Fawcett KA, 2010, TRENDS GENET, V26, P266, DOI 10.1016/j.tig.2010.02.006
   Ferdi NE, 2016, IRAN J PUBLIC HEALTH, V45, P1636
   Ferrante SC, 2015, PEDIATR RES, V77, P447, DOI 10.1038/pr.2014.202
   Ferreira FG, 2022, NUTRITION, V96, DOI 10.1016/j.nut.2022.111590
   Filippatos TD, 2013, WORLD J CARDIOL, V5, P317, DOI 10.4330/wjc.v5.i9.317
   Foraster M, 2018, ENVIRON INT, V121, P879, DOI 10.1016/j.envint.2018.09.057
   Franco OH, 2005, ARCH INTERN MED, V165, P2355, DOI 10.1001/archinte.165.20.2355
   Gahete MD, 2022, ENDOCR-RELAT CANCER, V29, pR123, DOI 10.1530/ERC-22-0019
   Garg T, 2020, J ECON BEHAV ORGAN, V180, P309, DOI 10.1016/j.jebo.2020.10.016
   Ge Q, 2014, J IMMUNOL RES, V2014, DOI 10.1155/2014/987285
   Ghai V, 2019, J CELL MOL MED, V23, P2753, DOI 10.1111/jcmm.14182
   Giambò F, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18168697
   Gill H, 2020, OBESITY, V28, P2064, DOI 10.1002/oby.22969
   González-Domínguez A, 2022, FREE RADICAL BIO MED, V191, P40, DOI 10.1016/j.freeradbiomed.2022.08.017
   Goyal R, 2010, REPROD SCI, V17, P227, DOI 10.1177/1933719109351935
   Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
   Grundy A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0099780
   Gualillo O, 2003, FEBS LETT, V552, P105, DOI 10.1016/S0014-5793(03)00965-7
   Guo CM, 2020, DIABETES OBES METAB, V22, P79, DOI 10.1111/dom.13867
   Gutiérrez-Cuevas J, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11020235
   Gutiérrez-Cuevas J, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10030629
   Guzzo-Merello G, 2014, WORLD J CARDIOL, V6, P771, DOI 10.4330/wjc.v6.i8.771
   Hajivandi L, 2020, BMC PEDIATR, V20, DOI 10.1186/s12887-020-02173-y
   Hamilton MT, 2014, MED SPORT SCI, V60, P11, DOI 10.1159/000357332
   Han YY, 2020, AM J CANCER RES, V10, P727
   Harris KK, 2016, NAT REV ENDOCRINOL, V12, P299, DOI 10.1038/nrendo.2016.32
   Hawkesworth S, 2018, J EPIDEMIOL COMMUN H, V72, P121, DOI 10.1136/jech-2017-209440
   Hiam D, 2019, J CLIN MED, V8, DOI 10.3390/jcm8101606
   Hildebrandt X, 2023, CELL DEATH DIFFER, V30, P279, DOI 10.1038/s41418-022-01062-4
   Hindy George, 2014, BMC Med Genet, V15, P1220, DOI 10.1186/s12881-014-0138-x
   Hobbs M, 2019, SOC SCI MED, V227, P76, DOI 10.1016/j.socscimed.2018.06.027
   Hu FB, 2000, AM J CLIN NUTR, V72, P912
   Huang JL, 2022, MOL MED, V28, DOI 10.1186/s10020-022-00446-z
   Huvenne H, 2016, OBESITY FACTS, V9, P158, DOI 10.1159/000445061
   Iacomino G, 2017, GENES NUTR, V12, DOI 10.1186/s12263-017-0577-z
   Inoue K, 2011, INTERNAL MED, V50, P707, DOI 10.2169/internalmedicine.50.4600
   Inzani I, 2022, P NUTR SOC, V81, P227, DOI 10.1017/S0029665122001914
   Jaramillo JD, 2015, ANN AM THORAC SOC, V12, P648, DOI 10.1513/AnnalsATS.201412-591OC
   Jiang WX, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-17086-7
   Jo BS, 2016, GENOMICS, V108, P84, DOI 10.1016/j.ygeno.2016.07.001
   Jones MR, 2015, PLOS GENET, V11, DOI 10.1371/journal.pgen.1005455
   Kabra DG, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms10782
   Karami-Mohajeri S, 2011, HUM EXP TOXICOL, V30, P1119, DOI 10.1177/0960327110388959
   Kathiresan S, 2012, CELL, V148, P1242, DOI 10.1016/j.cell.2012.03.001
   Katzmarzyk PT, 2022, BRIT J SPORT MED, V56, P101, DOI 10.1136/bjsports-2020-103640
   Kim SK, 2020, KOREAN J INTERN MED, V35, P369, DOI 10.3904/kjim.2019.133
   Kim TJ, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2017-019862
   Klatsky AL, 2015, J INTERN MED, V278, P238, DOI 10.1111/joim.12390
   Klok MD, 2007, OBES REV, V8, P21, DOI 10.1111/j.1467-789X.2006.00270.x
   Knott C, 2015, DIABETES CARE, V38, P1804, DOI 10.2337/dc15-0710
   Kobyliak N, 2016, NUTR J, V15, DOI 10.1186/s12937-016-0166-9
   Koch CA, 2021, HORM METAB RES, V53, P575, DOI 10.1055/a-1533-2861
   Kudo A, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-44477-9
   Lebrun B, 2006, AUTON NEUROSCI-BASIC, V126, P30, DOI 10.1016/j.autneu.2006.02.027
   Lee CJ, 2020, ANN NY ACAD SCI, V1461, P37, DOI 10.1111/nyas.14107
   Lee HY, 2022, NUTRIENTS, V14, DOI 10.3390/nu14010217
   LeMaire SA, 2011, NAT GENET, V43, P996, DOI 10.1038/ng.934
   Li LO, 2010, BBA-MOL CELL BIOL L, V1801, P246, DOI 10.1016/j.bbalip.2009.09.024
   Li XH, 2016, AM J CLIN NUTR, V103, P818, DOI 10.3945/ajcn.115.114389
   Li Y, 2022, EXP NEUROL, V348, DOI 10.1016/j.expneurol.2021.113949
   Ling Charlotte, 2022, Epigenetic epidemiology, P445, DOI 10.1007/978-3-030-94475-9_19
   Liu YN, 2022, REPROD TOXICOL, V111, P11, DOI 10.1016/j.reprotox.2022.04.010
   Lone JB, 2018, MICROB PATHOGENESIS, V124, P266, DOI 10.1016/j.micpath.2018.08.036
   Lu YN, 2020, MOL MED REP, V22, P1868, DOI 10.3892/mmr.2020.11281
   Lundgren P, 2020, AM J PHYSIOL-GASTR L, V318, pG717, DOI 10.1152/ajpgi.00304.2019
   Lustig RH, 2022, BIOCHEM PHARMACOL, V199, DOI 10.1016/j.bcp.2022.115012
   Lyu GL, 2018, BMC GENOMICS, V19, DOI 10.1186/s12864-018-4814-7
   Ma TKW, 2010, BRIT J PHARMACOL, V160, P1273, DOI 10.1111/j.1476-5381.2010.00750.x
   Ma YY, 2017, P NUTR SOC, V76, P333, DOI 10.1017/S0029665116000823
   Magkos F, 2020, OBESITY, V28, P73, DOI 10.1002/oby.22657
   Makker A, 2012, GYNECOL ENDOCRINOL, V28, P175, DOI 10.3109/09513590.2011.583955
   Makrinou E, 2020, MOL CELL ENDOCRINOL, V500, DOI 10.1016/j.mce.2019.110611
   Malik VS, 2006, AM J CLIN NUTR, V84, P274
   Mambiya M, 2019, FRONT PUBLIC HEALTH, V7, DOI 10.3389/fpubh.2019.00349
   Marco A, 2016, DIABETES, V65, P2258, DOI 10.2337/db15-1608
   Mario FM, 2017, J ENDOCRINOL INVEST, V40, P377, DOI 10.1007/s40618-016-0570-1
   Martini CN, 2016, J BIOCHEM MOL TOXIC, V30, P404, DOI 10.1002/jbt.21804
   Mattar P, 2022, OBESITY, V30, P1143, DOI 10.1002/oby.23411
   McArdle Maeve A, 2013, Front Endocrinol (Lausanne), V4, P52, DOI 10.3389/fendo.2013.00052
   Meggs WJ, 2007, J MED TOXICOL, V3, P89, DOI 10.1007/BF03160916
   Mendelson MM, 2017, PLOS MED, V14, DOI 10.1371/journal.pmed.1002215
   Monteleone P, 2013, PSYCHONEUROENDOCRINO, V38, P312, DOI 10.1016/j.psyneuen.2012.10.021
   Moseti D, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17010124
   Mostafalou S, 2017, ARCH TOXICOL, V91, P549, DOI 10.1007/s00204-016-1849-x
   Movassagh M, 2011, CIRCULATION, V124, P2411, DOI 10.1161/CIRCULATIONAHA.111.040071
   Münzel T, 2021, NAT REV CARDIOL, V18, P619, DOI 10.1038/s41569-021-00532-5
   Musunuru K, 2010, ANNU REV GENOM HUM G, V11, P91, DOI 10.1146/annurev-genom-082509-141637
   Nagaraju R, 2015, J DIABETES, V7, P47, DOI 10.1111/1753-0407.12158
   Nakanishi N, 2023, REPROD SCI, V30, P1306, DOI 10.1007/s43032-022-01095-7
   Nicolaidis S, 2019, METABOLISM, V100, DOI 10.1016/j.metabol.2019.07.006
   Nieuwenhuijsen MJ, 2018, NAT REV CARDIOL, V15, P432, DOI 10.1038/s41569-018-0003-2
   Nomura A, 2017, CIRC RES, V121, P81, DOI 10.1161/CIRCRESAHA.117.311145
   O'Keefe EL, 2018, PROG CARDIOVASC DIS, V61, P68, DOI 10.1016/j.pcad.2018.02.001
   Obradovic M, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.585887
   Ogden CL, 2012, JAMA-J AM MED ASSOC, V307, P483, DOI [10.1001/jama.2012.39, 10.1001/jama.2012.40]
   Oh A, 2019, FRONT CARDIOVASC MED, V6, DOI 10.3389/fcvm.2019.00110
   Ordovas JM, 2002, CIRCULATION, V106, P2315, DOI 10.1161/01.CIR.0000036597.52291.C9
   Özen S, 2015, J PEDIATR ENDOCR MET, V28, P691, DOI 10.1515/jpem-2014-0324
   Pandey A, 2018, JACC-HEART FAIL, V6, P975, DOI 10.1016/j.jchf.2018.09.006
   Paulo E, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-29333-6
   Pedroso JAB, 2019, HORM-INT J ENDOCRINO, V18, P127, DOI 10.1007/s42000-018-0078-5
   Perhonen MA, 2001, J APPL PHYSIOL, V91, P645, DOI 10.1152/jappl.2001.91.2.645
   Piccoli MT, 2017, CIRC RES, V121, P575, DOI 10.1161/CIRCRESAHA.117.310624
   Pigeyre M, 2016, CLIN SCI, V130, P943, DOI 10.1042/CS20160136
   Polak-Szczybylo E, 2022, NUTRIENTS, V14, DOI 10.3390/nu14030643
   Prasher D, 2020, BIOCHEM CELL BIOL, V98, P12, DOI 10.1139/bcb-2019-0045
   Qi L, 2017, ARTERIOSCL THROM VAS, V37, P2204, DOI [10.1161/ATVBAHA.117.309548, 10.1161/atvbaha.117.309548]
   Qu F, 2012, J MOL MED, V90, P911, DOI 10.1007/s00109-012-0881-4
   Raman P.G., 2016, Environmental Health Risk-Hazardous Factors to Living Species
   Rana MN, 2022, CURR DIABETES REP, V22, P27, DOI 10.1007/s11892-021-01446-9
   Rasheed MA, 2017, THER ADV ENDOCRINOL, V8, P97, DOI 10.1177/2042018817708910
   Raskin Erusan R., 2012, Open J Endocr Metab Dis, V2, P7, DOI DOI 10.4236/OJEMD.2012
   Rawat K, 2022, MOL HUM REPROD, V28, DOI 10.1093/molehr/gaac024
   Ren G, 2022, DIABETES, V71, DOI 10.2337/db22-1400-P
   Ren J, 2021, PHYSIOL REV, V101, P1745, DOI 10.1152/physrev.00030.2020
   Robker RL, 2011, J REPROD IMMUNOL, V88, P142, DOI 10.1016/j.jri.2011.01.008
   Rönn T, 2015, HUM MOL GENET, V24, P3792, DOI 10.1093/hmg/ddv124
   Rostamtabar M, 2021, J CELL PHYSIOL, V236, P824, DOI 10.1002/jcp.29912
   Roura E, 2014, INT J CANCER, V135, P453, DOI 10.1002/ijc.28666
   Roy SG, 2021, NUCLEUS CALCUTTA, V64, P317, DOI 10.1007/s13237-021-00378-9
   Rudnicka E, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22073789
   Sabaté-Pérez A, 2023, AUTOPHAGY, V19, P904, DOI 10.1080/15548627.2022.2111081
   Sabbah HN, 2020, JACC-BASIC TRANSL SC, V5, P88, DOI 10.1016/j.jacbts.2019.07.009
   Safi-Stibler S, 2020, SEMIN CELL DEV BIOL, V97, P172, DOI 10.1016/j.semcdb.2019.09.008
   Sagvekar P, 2022, MOL HUM REPROD, V28, DOI 10.1093/molehr/gaac019
   Sahu A, 2004, ENDOCRINOLOGY, V145, P2613, DOI 10.1210/en.2004-0032
   Saito S, 2009, PROG NEURO-PSYCHOPH, V33, P312, DOI 10.1016/j.pnpbp.2008.12.009
   Saponaro C, 2015, NUTRIENTS, V7, P9453, DOI 10.3390/nu7115475
   Sayers SR, 2020, DIABETOLOGIA, V63, P313, DOI 10.1007/s00125-019-05029-y
   Sayols-Baixeras S, 2017, EPIGENETICS-US, V12, P909, DOI 10.1080/15592294.2017.1363951
   Schwartz C, 2022, SCI TRANSL MED, V14, DOI 10.1126/scitranslmed.abj6879
   Scully T, 2021, FRONT ONCOL, V10, DOI 10.3389/fonc.2020.615375
   Serra-Juhé C, 2015, EPIGENETICS-US, V10, P167, DOI 10.1080/15592294.2014.998536
   Shai I, 2010, CIRCULATION, V121, P1200, DOI 10.1161/CIRCULATIONAHA.109.879254
   Shamriz O, 2017, CANCER CAUSE CONTROL, V28, P331, DOI [10.1007/s10552-017-0863-5, 10.1007/s10552-017-086]
   Sharma Mukesh, 2009, Indian J Occup Environ Med, V13, P109, DOI 10.4103/0019-5278.58912
   Rossi JLS, 2022, DIABETES-METAB RES, V38, DOI 10.1002/dmrr.3502
   Speakman JR, 2018, HAND CLINIC, V156, P431, DOI 10.1016/B978-0-444-63912-7.00026-6
   Stienstra R, 2014, DIABETOLOGIA, V57, P1505, DOI 10.1007/s00125-014-3255-3
   Sun QC, 2016, J AGR FOOD CHEM, V64, P9293, DOI 10.1021/acs.jafc.6b04322
   Sun X, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/926713
   Sverdlov AL, 2015, J MOL CELL CARDIOL, V78, P165, DOI 10.1016/j.yjmcc.2014.07.018
   Thannickal A, 2020, CLIN ENDOCRINOL, V92, P338, DOI 10.1111/cen.14153
   Tian Y, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00274
   Tong J, 2015, J CLIN INVEST, V125, P490, DOI 10.1172/JCI79187
   Trentinaglia MT, 2021, GLOB FOOD SECUR-AGR, V29, DOI 10.1016/j.gfs.2021.100539
   Tsai PC, 2018, CLIN EPIGENETICS, V10, DOI 10.1186/s13148-018-0558-0
   Van Gaal LF, 2006, NATURE, V444, P875, DOI 10.1038/nature05487
   Viscarra JA, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-14617-1
   Wabitsch M, 2015, NEW ENGL J MED, V372, P48, DOI 10.1056/NEJMoa1406653
   Wagner KH, 2012, PREV MED, V54, pS38, DOI 10.1016/j.ypmed.2011.11.012
   Walaszczyk E, 2018, DIABETOLOGIA, V61, P354, DOI 10.1007/s00125-017-4497-7
   Wang CF, 2010, BRAIN RES, V1336, P66, DOI 10.1016/j.brainres.2010.04.013
   Wang DY, 2022, LANCET PUBLIC HEALTH, V7, pE670, DOI 10.1016/S2468-2667(22)00157-8
   Wang J, 2011, BIRTH DEFECTS RES A, V91, P468, DOI 10.1002/bdra.20816
   Wang S, 2022, THERANOSTICS, V12, P1589, DOI 10.7150/thno.69054
   Wang XY, 2020, GENOMICS, V112, P1516, DOI 10.1016/j.ygeno.2019.08.023
   Webb TR, 2017, J AM COLL CARDIOL, V69, P823, DOI 10.1016/j.jacc.2016.11.056
   Weihrauch-Blüher S, 2019, METABOLISM, V92, P147, DOI 10.1016/j.metabol.2018.12.001
   Wen WQ, 2012, NAT GENET, V44, P307, DOI 10.1038/ng.1087
   Wieser V, 2013, ARCH IMMUNOL THER EX, V61, P119, DOI 10.1007/s00005-012-0210-1
   World Health Organization, 2021, WHO FACTSH OB OV
   World Health Organization, 2022, WHO FACTSH NONC DIS
   Xie LL, 2022, COMB CHEM HIGH T SCR, V25, P1304, DOI 10.2174/1386207321666210602170054
   Xie YY, 2022, J TRANSL MED, V20, DOI 10.1186/s12967-021-03220-7
   Xu L, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23169252
   Xu XJ, 2013, EPIGENETICS-US, V8, P522, DOI 10.4161/epi.24506
   Yan LH, 2022, BRAIN RES BULL, V185, P99, DOI 10.1016/j.brainresbull.2022.04.015
   Yan X, 2013, INT J OBESITY, V37, P568, DOI 10.1038/ijo.2012.69
   Yang D, 2022, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.822969
   Yang H, 2020, J CELL MOL MED, V24, P2384, DOI 10.1111/jcmm.14889
   Yang J, 2015, NAT GENET, V47, P1114, DOI 10.1038/ng.3390
   Yang J, 2022, J CELL PHYSIOL, V237, P98, DOI 10.1002/jcp.30534
   Ye JP, 2013, AM J PHYSIOL-ENDOC M, V304, pE466, DOI 10.1152/ajpendo.00266.2012
   Yeo GSH, 2004, NAT NEUROSCI, V7, P1187, DOI 10.1038/nn1336
   Youngwanichsetha S., 2020, GLOB J FERTIL RES, V5, P007, DOI [10.17352/gjfr.000015, DOI 10.17352/GJFR.000015]
   Zamora M, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20112833
   Zatterale F, 2020, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.01607
   Zdravkovic S, 2002, J INTERN MED, V252, P247, DOI 10.1046/j.1365-2796.2002.01029.x
   Zeng X, 2020, CLIN CHIM ACTA, V502, P214, DOI 10.1016/j.cca.2019.11.003
   Zhang KX, 2020, STEM CELLS INT, V2020, DOI 10.1155/2020/8892300
   Zhang YM, 2018, NAT REV ENDOCRINOL, V14, P356, DOI 10.1038/s41574-018-0009-1
   Zhang YM, 2016, PHARMACOL THERAPEUT, V161, P52, DOI 10.1016/j.pharmthera.2016.03.005
   Zheng Y, 2016, AM J CLIN NUTR, V103, P1179, DOI 10.3945/ajcn.115.107177
   Zhou FC, 2017, HANDBOOK OF EPIGENETICS: THE NEW MOLECULAR AND MEDICAL GENETICS, 2ND EDITION, P477, DOI 10.1016/B978-0-12-805388-1.00031-6
   Zhu TY, 2018, J MOL BIOL, V430, P363, DOI 10.1016/j.jmb.2017.12.003
   Ziv-Gal A, 2016, FERTIL STERIL, V106, P827, DOI 10.1016/j.fertnstert.2016.06.027
   Zivin J.G., 2010, Temperature and the allocation of time: Implications for climate change
NR 254
TC 7
Z9 7
U1 0
U2 21
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0029-568X
EI 0976-7975
J9 NUCLEUS CALCUTTA
JI Nucleus
PD AUG
PY 2023
VL 66
IS 2
BP 215
EP 237
DI 10.1007/s13237-023-00420-y
EA APR 2023
PG 23
WC Cell Biology
WE Emerging Sources Citation Index (ESCI)
SC Cell Biology
GA K4QV9
UT WOS:000967152600001
DA 2025-06-11
ER

PT J
AU Zgutka, K
   Tkacz, M
   Tomasiak, P
   Tarnowski, M
AF Zgutka, Katarzyna
   Tkacz, Marta
   Tomasiak, Patrycja
   Tarnowski, Maciej
TI A Role for Advanced Glycation End Products in Molecular Ageing
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE AGE; ageing; oxidative stress; inflammation; brain; age-related
   diseases; caloric restriction; physical activities
ID CARDIOMETABOLIC RISK-FACTORS; INCREASED PROTEIN GLYCATION; REDUCES
   OXIDATIVE STRESS; LOW-DENSITY-LIPOPROTEIN; CALORIC RESTRICTION;
   EXTRACELLULAR-MATRIX; MAILLARD REACTION; SOLUBLE RECEPTOR; AGE
   ACCUMULATION; OXIDANT STRESS
AB Ageing is a composite process that involves numerous changes at the cellular, tissue, organ and whole-body levels. These changes result in decreased functioning of the organism and the development of certain conditions, which ultimately lead to an increased risk of death. Advanced glycation end products (AGEs) are a family of compounds with a diverse chemical nature. They are the products of non-enzymatic reactions between reducing sugars and proteins, lipids or nucleic acids and are synthesised in high amounts in both physiological and pathological conditions. Accumulation of these molecules increases the level of damage to tissue/organs structures (immune elements, connective tissue, brain, pancreatic beta cells, nephrons, and muscles), which consequently triggers the development of age-related diseases, such as diabetes mellitus, neurodegeneration, and cardiovascular and kidney disorders. Irrespective of the role of AGEs in the initiation or progression of chronic disorders, a reduction in their levels would certainly provide health benefits. In this review, we provide an overview of the role of AGEs in these areas. Moreover, we provide examples of lifestyle interventions, such as caloric restriction or physical activities, that may modulate AGE formation and accumulation and help to promote healthy ageing.
C1 [Zgutka, Katarzyna; Tkacz, Marta; Tarnowski, Maciej] Pomeranian Med Univ, Fac Hlth Sci, Dept Physiol Hlth Sci, Zolnierska 54, PL-70210 Szczecin, Poland.
   [Tomasiak, Patrycja] Univ Szczecin, Inst Phys Culture Sci, PL-70453 Szczecin, Poland.
C3 Pomeranian Medical University; University of Szczecin
RP Tarnowski, M (corresponding author), Pomeranian Med Univ, Fac Hlth Sci, Dept Physiol Hlth Sci, Zolnierska 54, PL-70210 Szczecin, Poland.
EM maciejt@pum.edu.pl
RI Tkacz, Marta/ABD-7770-2020; Tarnowski, Maciej/J-6292-2014; Zgutka,
   Katarzyna/M-8352-2014
OI Tarnowski, Maciej/0000-0002-3869-5077; Zgutka,
   Katarzyna/0000-0003-1445-6562
CR Addi UR, 2022, CHEM-BIOL INTERACT, V355, DOI 10.1016/j.cbi.2022.109840
   Ahmed N, 2005, ANN NY ACAD SCI, V1043, P718, DOI 10.1196/annals.1333.083
   Ahmed N, 2005, J NEUROCHEM, V92, P255, DOI 10.1111/j.1471-4159.2004.02864.x
   Ahmed N, 2003, BBA-MOL BASIS DIS, V1639, P121, DOI 10.1016/j.bbadis.2003.08.002
   Akhter F, 2021, FREE RADICAL BIO MED, V164, P429, DOI 10.1016/j.freeradbiomed.2020.12.021
   Alikhani M, 2007, AM J PHYSIOL-CELL PH, V292, pC850, DOI 10.1152/ajpcell.00356.2006
   Allaman I, 2015, FRONT NEUROSCI-SWITZ, V9, DOI 10.3389/fnins.2015.00023
   Almajwal AM, 2020, FOOD SCI NUTR, V8, P1046, DOI 10.1002/fsn3.1389
   Ando K, 2018, ANTICANCER RES, V38, P3411, DOI 10.21873/anticanres.12609
   Anwar S, 2021, MOL BIOL REP, V48, P787, DOI 10.1007/s11033-020-06084-0
   Arnold P, 2018, EXP GERONTOL, V108, P118, DOI 10.1016/j.exger.2018.04.002
   Asadipooya K, 2019, J ENDOCR SOC, V3, P1799, DOI 10.1210/js.2019-00160
   Asif M, 2000, P NATL ACAD SCI USA, V97, P2809, DOI 10.1073/pnas.040558497
   Atzeni IM, 2022, METHODS, V203, P533, DOI 10.1016/j.ymeth.2021.02.016
   Avagimyan A, 2022, CURR PROB CARDIOLOGY, V47, DOI 10.1016/j.cpcardiol.2022.101156
   Avery NC, 2006, PATHOL BIOL, V54, P387, DOI 10.1016/j.patbio.2006.07.005
   Ballotari P, 2017, BMC CANCER, V17, DOI 10.1186/s12885-017-3696-4
   Bansal S, 2012, MOL CELL BIOCHEM, V361, P289, DOI 10.1007/s11010-011-1114-9
   Barile GR, 2005, INVEST OPHTH VIS SCI, V46, P2916, DOI 10.1167/iovs.04-1409
   Basta G, 2008, ATHEROSCLEROSIS, V196, P9, DOI 10.1016/j.atherosclerosis.2007.07.025
   Beisswenger PJ, 2003, BIOCHEM SOC T, V31, P1358
   BROWNLEE M, 1984, ANN INTERN MED, V101, P527, DOI 10.7326/0003-4819-101-4-527
   Bucciarelli LG, 2002, CIRCULATION, V106, P2827, DOI 10.1161/01.CIR.0000039325.03698.36
   Busch M, 2010, EUR J CLIN INVEST, V40, P742, DOI 10.1111/j.1365-2362.2010.02317.x
   Byun K, 2017, PHARMACOL THERAPEUT, V177, P44, DOI 10.1016/j.pharmthera.2017.02.030
   Byun K, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0037917
   Fernández SC, 2021, MED FAM-SEMERGEN, V47, P515, DOI 10.1016/j.semerg.2021.07.014
   Cai WJ, 2008, AM J PATHOL, V173, P327, DOI 10.2353/ajpath.2008.080152
   Cai WJ, 2008, AM J PHYSIOL-CELL PH, V294, pC145, DOI 10.1152/ajpcell.00350.2007
   Cai WJ, 2006, P NATL ACAD SCI USA, V103, P13801, DOI 10.1073/pnas.0600362103
   Cai WJ, 2014, P NATL ACAD SCI USA, V111, P4940, DOI 10.1073/pnas.1316013111
   Cai WJ, 2004, CIRCULATION, V110, P285, DOI 10.1161/01.CIR.0000135587.92455.0D
   Cai ZY, 2016, CELL MOL NEUROBIOL, V36, P483, DOI 10.1007/s10571-015-0233-3
   Cao CW, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030870
   Cao XY, 2019, CHEM BIODIVERS, V16, DOI 10.1002/cbdv.201900174
   Carlo-Stella N, 2009, INT J IMMUNOPATH PH, V22, P745, DOI 10.1177/039463200902200320
   Cepas V, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9020142
   Cerami C, 1997, P NATL ACAD SCI USA, V94, P13915, DOI 10.1073/pnas.94.25.13915
   Chavakis T, 2004, MICROBES INFECT, V6, P1219, DOI 10.1016/j.micinf.2004.08.004
   Chawla D, 2014, MICROVASC RES, V95, P1, DOI 10.1016/j.mvr.2014.06.010
   Chen CY, 2022, FRONT MED-LAUSANNE, V9, DOI 10.3389/fmed.2022.837222
   Chen C, 2020, MECH AGEING DEV, V187, DOI 10.1016/j.mad.2020.111215
   Chen JL, 2020, AM J CLIN NUTR, V112, P129, DOI 10.1093/ajcn/nqaa117
   Chen MY, 2001, BIOCHEM BIOPH RES CO, V287, P962, DOI 10.1006/bbrc.2001.5674
   Chen SC, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17040565
   Chen YJ, 2021, J IMMUNOTOXICOL, V18, P93, DOI 10.1080/1547691X.2021.1959677
   Choi KM, 2012, J CLIN ENDOCR METAB, V97, P3751, DOI 10.1210/jc.2012-1951
   Choudhuri S, 2013, MOL VIS, V19, P100
   Chuah YK, 2013, INT J INFLAMM, V2013, DOI 10.1155/2013/403460
   Colhoun HM, 2011, DIABETES, V60, P2379, DOI 10.2337/db11-0291
   Conner JR, 2005, ANN NY ACAD SCI, V1043, P824, DOI 10.1196/annals.1333.095
   Cordain L, 2005, AM J CLIN NUTR, V81, P341, DOI 10.1093/ajcn.81.2.341
   Corica D, 2022, METHODS, V203, P90, DOI 10.1016/j.ymeth.2021.12.008
   Cortes-Canteli M, 2020, J AM COLL CARDIOL, V75, P942, DOI 10.1016/j.jacc.2019.10.062
   Crisan M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0075003
   Cruz-Jentoft AJ, 2019, LANCET, V393, P2636, DOI 10.1016/S0140-6736(19)31138-9
   da Silva PFL, 2021, J INVEST DERMATOL, V141, P951, DOI 10.1016/j.jid.2020.11.018
   Dahlmann M, 2014, ONCOTARGET, V5, P3220, DOI 10.18632/oncotarget.1908
   Dattilo BM, 2007, BIOCHEMISTRY-US, V46, P6957, DOI 10.1021/bi7003735
   Delbin MA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0053318
   Deluyker D, 2016, INT J CARDIOL, V210, P100, DOI 10.1016/j.ijcard.2016.02.095
   Dickerson TJ, 2002, P NATL ACAD SCI USA, V99, P15084, DOI 10.1073/pnas.222561699
   Dobi A, 2021, MICROVASC RES, V133, DOI 10.1016/j.mvr.2020.104098
   Donato AJ, 2013, AGING CELL, V12, P772, DOI 10.1111/acel.12103
   Dorn GW, 2015, EMBO MOL MED, V7, P865, DOI 10.15252/emmm.201404575
   Dozio E, 2017, MEDIAT INFLAMM, V2017, DOI 10.1155/2017/9845175
   Drenth H, 2018, J GERONTOL A-BIOL, V73, P1545, DOI 10.1093/gerona/gly108
   Duda-Sobczak A, 2018, CLIN THER, V40, P872, DOI 10.1016/j.clinthera.2018.02.016
   Egawa T, 2022, FRONT PHYSIOL, V13, DOI 10.3389/fphys.2022.855358
   Egawa T, 2017, BRIT J NUTR, V117, P21, DOI 10.1017/S0007114516004591
   Eguchi Y, 2021, J WOMEN AGING, V33, P328, DOI 10.1080/08952841.2019.1697161
   Erusalimsky JD, 2021, REDOX BIOL, V42, DOI 10.1016/j.redox.2021.101958
   Falcone C, 2013, SCI WORLD J, DOI 10.1155/2013/584504
   Farinha JB, 2018, J DIABETES COMPLICAT, V32, P1124, DOI 10.1016/j.jdiacomp.2018.09.008
   Federico G, 2016, SAGE OPEN MED, V4, DOI 10.1177/2050312116682126
   Fishman SL, 2018, MOL MED, V24, DOI 10.1186/s10020-018-0060-3
   Fleming TH, 2011, GERONTOLOGY, V57, P435, DOI 10.1159/000322087
   Fotheringham AK, 2022, NUTRIENTS, V14, DOI 10.3390/nu14132675
   Fournet M, 2018, AGING DIS, V9, P880, DOI 10.14336/AD.2017.1121
   Frimat M, 2017, CLIN SCI, V131, P1069, DOI 10.1042/CS20160823
   Gill V, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9120888
   Gillies AR, 2011, MUSCLE NERVE, V44, P318, DOI 10.1002/mus.22094
   Gladyshev VN, 2021, NATURE AGING, V1, P1096, DOI 10.1038/s43587-021-00150-3
   Glenn JV, 2009, INVEST OPHTH VIS SCI, V50, P441, DOI 10.1167/iovs.08-1724
   Goldberg T, 2004, J AM DIET ASSOC, V104, P1287, DOI 10.1016/j.jada.2004.05.214
   Goon JA, 2009, J PHYS ACT HEALTH, V6, P43, DOI 10.1123/jpah.6.1.43
   Goova MT, 2001, AM J PATHOL, V159, P513, DOI 10.1016/S0002-9440(10)61723-3
   Gopal P, 2012, EUR J CLIN INVEST, V42, P807, DOI 10.1111/j.1365-2362.2012.02646.x
   Goudarzi R, 2020, J DIABETES METAB DIS, V19, P1129, DOI 10.1007/s40200-020-00614-0
   Granic A, 2023, MECH AGEING DEV, V209, DOI 10.1016/j.mad.2022.111744
   Greenwald SE, 2007, J PATHOL, V211, P157, DOI 10.1002/path.2101
   Gu MJ, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11050934
   Gugliucci A, 2009, ANN NUTR METAB, V54, P197, DOI 10.1159/000217817
   Gurbuz O, 2022, J OBSTET GYNAECOL, V42, P3048, DOI 10.1080/01443615.2022.2081796
   Gursinsky T, 2006, BIOL CHEM, V387, P1411, DOI 10.1515/BC.2006.177
   Habib Samy L, 2013, ISRN Oncol, V2013, P583786, DOI 10.1155/2013/583786
   Han XQ, 2014, J HUAZHONG U SCI-MED, V34, P10, DOI 10.1007/s11596-014-1224-1
   Harvey A, 2015, J MOL CELL CARDIOL, V83, P112, DOI 10.1016/j.yjmcc.2015.04.011
   He CJ, 2000, KIDNEY INT, V58, P1931, DOI 10.1111/j.1523-1755.2000.00365.x
   He LB, 2022, MOLECULES, V27, DOI 10.3390/molecules27206995
   Heidari F, 2019, CYTOKINE, V120, P186, DOI 10.1016/j.cyto.2019.05.007
   Henning RJ, 2018, FUTUR CARDIOL, V14, DOI 10.2217/fca-2018-0045
   Hipkiss AR, 2006, EXP GERONTOL, V41, P464, DOI 10.1016/j.exger.2006.03.004
   Hofmann SM, 2002, DIABETES, V51, P2082, DOI 10.2337/diabetes.51.7.2082
   Hooshiar S.H., 2020, HEART MIND, V6, P139
   Horiuchi S, 2003, AMINO ACIDS, V25, P283, DOI 10.1007/s00726-003-0029-5
   Hudson BI, 2014, METABOLISM, V63, P1125, DOI 10.1016/j.metabol.2014.05.011
   Ito D, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0138037
   Ivancovsky-Wajcman D, 2019, CLIN TRANSL GASTROEN, V10, DOI 10.14309/ctg.0000000000000040
   Iwashige Kenichi, 2004, Journal of Physiological Anthropology and Applied Human Science, V23, P19, DOI 10.2114/jpa.23.19
   Jamwal S, 2018, INFLAMM RES, V67, P391, DOI 10.1007/s00011-018-1129-8
   Jee SH, 2005, JAMA-J AM MED ASSOC, V293, P194, DOI 10.1001/jama.293.2.194
   Jeong SR, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22126530
   Jono T, 2002, FEBS LETT, V511, P170, DOI 10.1016/S0014-5793(01)03325-7
   Kalapos MP, 1999, TOXICOL LETT, V110, P145, DOI 10.1016/S0378-4274(99)00160-5
   Kalea AZ, 2011, FRONT BIOSCI-LANDMRK, V16, P2756, DOI 10.2741/3884
   Kang YT, 2021, AGING-US, V13, P12143, DOI 10.18632/aging.202924
   Kashiwabara S, 2019, J NUTR SCI VITAMINOL, V65, P526, DOI 10.3177/jnsv.65.526
   Kato M, 2017, GERIATR GERONTOL INT, V17, P785, DOI 10.1111/ggi.12787
   KELLEHER DJ, 1992, CELL, V69, P55, DOI 10.1016/0092-8674(92)90118-V
   Kellow NJ, 2018, EUR J NUTR, V57, P2209, DOI 10.1007/s00394-017-1495-y
   Khan R., 2019, The Eye and Foot in Diabetes, DOI DOI 10.5772/INTECHOPEN.89408
   Kislinger T, 1999, J BIOL CHEM, V274, P31740, DOI 10.1074/jbc.274.44.31740
   Kisugi R, 2007, CLIN CHIM ACTA, V382, P59, DOI 10.1016/j.cca.2007.04.001
   Kitai Y, 2021, CONTRIB NEPHROL, V199, P266, DOI 10.1159/000517708
   Kitaura A, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0245957
   Kong X, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/9692546
   Koschinsky T, 1997, P NATL ACAD SCI USA, V94, P6474, DOI 10.1073/pnas.94.12.6474
   Kosmopoulos M, 2019, BBA-MOL BASIS DIS, V1865, P611, DOI 10.1016/j.bbadis.2019.01.006
   Kotani Kazuhiko, 2011, J Clin Med Res, V3, P252, DOI 10.4021/jocmr704w
   KueperO T, 2007, J BIOL CHEM, V282, P23427, DOI 10.1074/jbc.M701586200
   Kumar PA, 2016, ARCH BIOCHEM BIOPHYS, V590, P10, DOI 10.1016/j.abb.2015.11.003
   Laina A, 2018, EXP GERONTOL, V109, P16, DOI 10.1016/j.exger.2017.06.007
   Lakatta EG, 2013, ARTERY RES, V7, P73, DOI 10.1016/j.artres.2013.01.003
   Lan L, 2015, MOL MED REP, V11, P4321, DOI 10.3892/mmr.2015.3317
   Lee J, 2022, NUTRIENTS, V14, DOI 10.3390/nu14153086
   Lee JG, 2012, J ETHNOPHARMACOL, V139, P739, DOI 10.1016/j.jep.2011.11.049
   Lega IC, 2020, ENDOCR REV, V41, P33, DOI 10.1210/endrev/bnz014
   Leslie RDG, 2003, DIABETES, V52, P2441, DOI 10.2337/diabetes.52.9.2441
   Li Z, 2017, BIOSCIENCE REP, V37, DOI 10.1042/BSR20170213
   Liang YB, 2021, FRONT CELL NEUROSCI, V14, DOI 10.3389/fncel.2020.540669
   Lim M, 2008, ANN NY ACAD SCI, V1150, P311, DOI 10.1196/annals.1447.011
   LIU H, 2005, DIABETES, V54, pA21
   Loomis SJ, 2017, CLIN CHEM, V63, P980, DOI 10.1373/clinchem.2016.264135
   Lopes-Virella MF, 2013, DIABETES CARE, V36, P2317, DOI 10.2337/dc12-2521
   Luevano-Contreras C, 2010, NUTRIENTS, V2, P1247, DOI 10.3390/nu2121247
   Luo PL, 2015, MOL MED REP, V11, P4447, DOI 10.3892/mmr.2015.3269
   Ma H, 2009, J CELL MOL MED, V13, P1751, DOI 10.1111/j.1582-4934.2008.00547.x
   Maillard-Lefebvre H, 2009, RHEUMATOLOGY, V48, P1190, DOI 10.1093/rheumatology/kep199
   MAKITA Z, 1991, NEW ENGL J MED, V325, P836, DOI 10.1056/NEJM199109193251202
   MAKITA Z, 1994, LANCET, V343, P1519, DOI 10.1016/S0140-6736(94)92935-1
   Malik P, 2015, BBA-GEN SUBJECTS, V1850, P1898, DOI 10.1016/j.bbagen.2015.05.020
   Martens RJH, 2020, CLIN KIDNEY J, V13, P855, DOI 10.1093/ckj/sfz099
   Matsumoto S, 2022, ARCH GERONTOL GERIAT, V101, DOI 10.1016/j.archger.2022.104704
   Mitchell WK, 2012, FRONT PHYSIOL, V3, DOI 10.3389/fphys.2012.00260
   Miyata T, 1996, J AM SOC NEPHROL, V7, P1198
   Miyata T, 1997, KIDNEY INT, V51, P1170, DOI 10.1038/ki.1997.160
   Miyazaki A, 2002, TRENDS CARDIOVAS MED, V12, P258, DOI 10.1016/S1050-1738(02)00171-8
   Miyoshi A, 2019, FASEB J, V33, P3575, DOI 10.1096/fj.201701553RR
   Moldogazieva NT, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/3085756
   Momma H, 2011, EUR J APPL PHYSIOL, V111, P1545, DOI 10.1007/s00421-010-1779-x
   Monnier VM, 2005, ANN NY ACAD SCI, V1043, P533, DOI 10.1196/annals.1333.061
   Nagaraj RH, 2012, AMINO ACIDS, V42, P1205, DOI 10.1007/s00726-010-0778-x
   Nakamura K, 2007, MOL MED, V13, P185, DOI 10.2119/2006-00090.Nakamura
   Navaratna D, 2013, J CLIN INVEST, V123, P3373, DOI 10.1172/JCI65767
   Nelson MB, 2015, AM J PHYSIOL-HEART C, V309, pH63, DOI 10.1152/ajpheart.00043.2015
   Nguyen H P, 2015, Skin Therapy Lett, V20, P1
   Nicholl ID, 1998, MOL MED, V4, P594, DOI 10.1007/BF03401759
   Nowotny K, 2018, AGEING RES REV, V47, P55, DOI 10.1016/j.arr.2018.06.005
   Nursten HE, 2005, MAILLARD REACTION: CHEMISTRY, BIOCHEMISTRY AND IMPLICATIONS, P1, DOI 10.1039/9781847552570
   Olson LC, 2021, BIOENGINEERING-BASEL, V8, DOI 10.3390/bioengineering8110168
   Otero K, 2001, BIOCHEM J, V359, P567, DOI 10.1042/0264-6021:3590567
   Ott C, 2014, REDOX BIOL, V2, P411, DOI 10.1016/j.redox.2013.12.016
   Ottum MS, 2015, J CLIN BIOCHEM NUTR, V57, P1, DOI 10.3164/jcbn.15-3
   Pageon H, 2021, J AGING RES, V2021, DOI 10.1155/2021/6647773
   Pandey KB, 2009, OXID MED CELL LONGEV, V2, P270, DOI 10.4161/oxim.2.5.9498
   Pang YJ, 2018, J EPIDEMIOL COMMUN H, V72, P919, DOI 10.1136/jech-2018-210651
   Papagrigoraki A, 2017, ACTA DERM-VENEREOL, V97, P782, DOI 10.2340/00015555-2661
   Paramita N, 2022, J NUTR METAB, V2022, DOI 10.1155/2022/5631488
   Park SH, 2017, NUTRIENTS, V9, DOI 10.3390/nu9111214
   Pasupulati Anil Kumar, 2016, BioMolecular Concepts, V7, P293, DOI 10.1515/bmc-2016-0021
   Payne GW, 2006, MICROCIRCULATION, V13, P315, DOI 10.1080/10739680600618918
   Peng ZY, 2017, STEM CELL TRANSL MED, V6, P261, DOI 10.5966/sctm.2015-0380
   Perrone A, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/3818196
   Politz O, 2002, BIOCHEM J, V362, P155, DOI 10.1042/0264-6021:3620155
   Porter M. M., 1995, Scandinavian Journal of Medicine and Science in Sports, V5, P129
   Poulsen MW, 2013, FOOD CHEM TOXICOL, V60, P10, DOI 10.1016/j.fct.2013.06.052
   Prasad C, 2019, AM J LIFESTYLE MED, V13, P384, DOI 10.1177/1559827617708991
   Prasad K, 2018, INT J ANGIOL, V27, P1, DOI 10.1055/s-0037-1613678
   Prasad K, 2014, INT J ANGIOL, V23, P11, DOI 10.1055/s-0033-1363423
   Price CL, 2004, DIABETES, V53, P1452, DOI 10.2337/diabetes.53.6.1452
   Puddu A, 2010, BIOCHEM BIOPH RES CO, V395, P122, DOI 10.1016/j.bbrc.2010.03.152
   Pugliese G, 2001, FASEB J, V15, P2471, DOI 10.1096/fj.01-0006com
   Qiu XL, 2010, CELL METAB, V12, P662, DOI 10.1016/j.cmet.2010.11.015
   Rabbani N, 2012, AMINO ACIDS, V42, P1133, DOI 10.1007/s00726-010-0783-0
   RAHBAR S, 1969, BIOCHEM BIOPH RES CO, V36, P838, DOI 10.1016/0006-291X(69)90685-8
   Rahmani AH, 2022, APPL SCI-BASEL, V12, DOI 10.3390/app12189175
   Raucci A, 2008, FASEB J, V22, P3716, DOI 10.1096/fj.08-109033
   Rodrigues KL, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01641
   Roggerio A, 2018, NUTRIENTS, V10, DOI 10.3390/nu10070937
   Rom S, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-75940-7
   Rowan S, 2018, BBA-MOL BASIS DIS, V1864, P3631, DOI 10.1016/j.bbadis.2018.08.036
   Roy S, 2015, EXP EYE RES, V133, P58, DOI 10.1016/j.exer.2014.08.011
   Ruiz HH, 2020, ENDOCRINOLOGY, V161, DOI 10.1210/endocr/bqz006
   Rungratanawanich W, 2021, EXP MOL MED, V53, P168, DOI 10.1038/s12276-021-00561-7
   Sakaguchi T, 2003, J CLIN INVEST, V111, P959, DOI 10.1172/JCI200317115
   Santilli F, 2013, THROMB HAEMOSTASIS, V110, P1232, DOI 10.1160/TH13-04-0295
   Schalkwijk CG, 2012, AMINO ACIDS, V42, P1193, DOI 10.1007/s00726-010-0779-9
   Scheijen JLJM, 2018, CLIN NUTR, V37, P919, DOI 10.1016/j.clnu.2017.03.019
   SCHMIDT AM, 1994, P NATL ACAD SCI USA, V91, P8807, DOI 10.1073/pnas.91.19.8807
   Schmidt AM, 2015, VASC PHARMACOL, V72, P1, DOI 10.1016/j.vph.2015.06.011
   Schröter D, 2018, CURR PHARM DESIGN, V24, P5245, DOI 10.2174/1381612825666190130145549
   Seals DR, 2018, J APPL PHYSIOL, V125, P1841, DOI 10.1152/japplphysiol.00448.2018
   Sell DR, 2003, J GERONTOL A-BIOL, V58, P508
   Semba RD, 2010, J GERONTOL A-BIOL, V65, P963, DOI 10.1093/gerona/glq074
   Semba RD, 2010, J RENAL NUTR, V20, P74, DOI 10.1053/j.jrn.2009.08.001
   Semba RD, 2009, AM J KIDNEY DIS, V53, P51, DOI 10.1053/j.ajkd.2008.06.018
   Semba R, 2009, EUR J NUTR, V48, P38, DOI 10.1007/s00394-008-0757-0
   Sergi D, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00532
   Sessa L, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0086903
   Sharaf H, 2015, BBA-MOL BASIS DIS, V1852, P429, DOI 10.1016/j.bbadis.2014.12.009
   Sharma A, 2020, REDOX BIOL, V34, DOI 10.1016/j.redox.2020.101546
   Sharma Yashodhara, 2012, J Ocul Biol Dis Infor, V5, P63, DOI 10.1007/s12177-013-9104-7
   Shaw SS, 2003, DIABETES, V52, P2381, DOI 10.2337/diabetes.52.9.2381
   Shinmura K, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/528935
   Shoji T, 2006, DIABETES, V55, P2245, DOI 10.2337/db05-1375
   Shu TT, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0018782
   Singh VP, 2014, KOREAN J PHYSIOL PHA, V18, P1, DOI 10.4196/kjpp.2014.18.1.1
   Sohal RS, 2000, RES PRO CEL, V29, P45
   Song F, 2014, DIABETES, V63, P1948, DOI 10.2337/db13-1636
   Song QH, 2021, BIOMED PHARMACOTHER, V140, DOI 10.1016/j.biopha.2021.111750
   Sorci G, 2013, BBA-MOL CELL RES, V1833, P101, DOI 10.1016/j.bbamcr.2012.10.021
   Sponder M, 2018, HEART VESSELS, V33, P893, DOI 10.1007/s00380-018-1125-5
   Stirban A, 2013, DIABETES CARE, V36, P1278, DOI 10.2337/dc12-1489
   Stitt AW, 1997, ANN NY ACAD SCI, V811, P115, DOI 10.1111/j.1749-6632.1997.tb51994.x
   Striker LJ, 1996, NEPHROL DIAL TRANSPL, V11, P62
   Tabara Y, 2019, J GERONTOL A-BIOL, V74, P1446, DOI 10.1093/gerona/gly233
   TAKAHASHI M, 1993, DIABETOLOGIA, V36, P664, DOI 10.1007/BF00404078
   Takeuchi M, 2008, CURR PHARM DESIGN, V14, P973, DOI 10.2174/138161208784139693
   Takeuchi M, 2009, J ALZHEIMERS DIS, V16, P845, DOI 10.3233/JAD-2009-0974
   Takino J, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-82619-0
   Tamura Y, 2003, J BIOL CHEM, V278, P12613, DOI 10.1074/jbc.M210211200
   Teillet L, 2002, MECH AGEING DEV, V123, P427, DOI 10.1016/S0047-6374(01)00400-6
   Teillet L, 2000, J AM SOC NEPHROL, V11, P1488, DOI 10.1681/ASN.V1181488
   Thieme K, 2021, LIFE SCI, V270, DOI 10.1016/j.lfs.2020.118997
   THORNALLEY PJ, 1993, MOL ASPECTS MED, V14, P287, DOI 10.1016/0098-2997(93)90002-U
   Thornalley PJ, 2003, BIOCHEM J, V375, P581, DOI 10.1042/BJ20030763
   Thorpe SR, 2003, AMINO ACIDS, V25, P275, DOI 10.1007/s00726-003-0017-9
   Ton ALY, 2007, SEMIN NEPHROL, V27, P130, DOI 10.1016/j.semnephrol.2007.01.006
   Tosato M, 2007, CLIN INTERV AGING, V2, P401
   Twarda-Clapa A, 2022, CELLS-BASEL, V11, DOI 10.3390/cells11081312
   Uhle F, 2017, INFLAMM RES, V66, P961, DOI 10.1007/s00011-017-1076-9
   Ungvari Z, 2008, CIRC RES, V102, P519, DOI 10.1161/CIRCRESAHA.107.168369
   Uribarri J, 2007, J GERONTOL A-BIOL, V62, P427, DOI 10.1093/gerona/62.4.427
   Uribarri J, 2014, AMINO ACIDS, V46, P301, DOI 10.1007/s00726-013-1502-4
   Uribarri J, 2010, J AM DIET ASSOC, V110, P911, DOI 10.1016/j.jada.2010.03.018
   Van Heijst JWJ, 2005, ANN NY ACAD SCI, V1043, P725, DOI 10.1196/annals.1333.084
   Veiga-Da-Cunha M, 2006, BIOCHEM J, V399, P257, DOI 10.1042/BJ20060684
   Verzijl N, 2000, J BIOL CHEM, V275, P39027, DOI 10.1074/jbc.M006700200
   Villa M, 2017, METABOLISM, V71, P64, DOI 10.1016/j.metabol.2017.03.004
   Vlassara H, 2004, REV ENDOCR METAB DIS, V5, P181, DOI 10.1023/B:REMD.0000032406.84813.f6
   VLASSARA H, 1995, MOL MED, V1, P634, DOI 10.1007/BF03401604
   Walker D, 2015, EXPERT OPIN INV DRUG, V24, P393, DOI 10.1517/13543784.2015.1001490
   Wannamethee SG, 2017, ATHEROSCLEROSIS, V264, P36, DOI 10.1016/j.atherosclerosis.2017.07.008
   Wear-Maggitti K, 2004, ANN PLAS SURG, V52, P519, DOI 10.1097/01.sap.0000122857.49274.8c
   Wrigglesworth J, 2021, BMC NEUROL, V21, DOI 10.1186/s12883-021-02331-4
   Xiao JB, 2015, CURR MED CHEM, V22, P23
   Xin C, 2021, J COSMET DERMATOL-US, V20, P243, DOI 10.1111/jocd.13452
   Xue MZ, 2011, SEMIN CELL DEV BIOL, V22, P293, DOI 10.1016/j.semcdb.2011.02.013
   Yamagishi S, 2005, MED HYPOTHESES, V64, P1208, DOI 10.1016/j.mehy.2005.01.015
   Yamagishi S, 2002, J BIOL CHEM, V277, P20309, DOI 10.1074/jbc.M202634200
   Yamagishi S, 2012, REJUV RES, V15, P564, DOI 10.1089/rej.2012.1335
   Yamagishi S, 2011, EXP GERONTOL, V46, P217, DOI 10.1016/j.exger.2010.11.007
   Yamagishi Sho-ichi, 2010, Front Biosci (Elite Ed), V2, P1184
   YANG Z, 1991, J EXP MED, V174, P515, DOI 10.1084/jem.174.3.515
   Yoshihara K, 1998, BIOL PHARM BULL, V21, P1005
   Yoshikawa T, 2009, MED SCI MONITOR, V15, pPH65
   Yoshimaru T, 2008, BBA-MOL CELL RES, V1783, P2332, DOI 10.1016/j.bbamcr.2008.08.010
   Yoshinaga E, 2012, J INVEST DERMATOL, V132, P315, DOI 10.1038/jid.2011.298
   Younus H, 2016, INT J HEALTH SCI-IJH, V10, P261
   Yuan Q, 2014, CLIN EXP PHARMACOL P, V41, P127, DOI 10.1111/1440-1681.12194
   Zawada A, 2022, NUTRIENTS, V14, DOI 10.3390/nu14193982
   Zeng C, 2019, TRENDS ENDOCRIN MET, V30, P959, DOI 10.1016/j.tem.2019.08.005
   Zgutka K, 2021, POSTEPY BIOL KOMORKI, V48, P249
   Zhang L, 2008, J BIOL CHEM, V283, P35507, DOI 10.1074/jbc.M806948200
   Zhang YX, 2021, BIOENGINEERED, V12, P1360, DOI 10.1080/21655979.2021.1917980
   Zhu P, 2011, ARCH DERMATOL RES, V303, P339, DOI 10.1007/s00403-010-1102-z
   Zhu YX, 2011, BIOCHEM BIOPH RES CO, V404, P159, DOI 10.1016/j.bbrc.2010.11.085
   Zhuang AW, 2021, ENDOCRIN DIAB METAB, V4, DOI 10.1002/edm2.278
   Zhuang AW, 2016, GLYCOCONJUGATE J, V33, P645, DOI 10.1007/s10719-016-9693-z
   Zong HL, 2011, CURR DIABETES REP, V11, P244, DOI 10.1007/s11892-011-0198-7
NR 291
TC 50
Z9 51
U1 1
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN
PY 2023
VL 24
IS 12
AR 9881
DI 10.3390/ijms24129881
PG 36
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA K3AT3
UT WOS:001015205600001
PM 37373042
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Akhter, N
   Wilson, A
   Arefanian, H
   Thomas, R
   Kochumon, S
   Al-Rashed, F
   Abu-Farha, M
   Al-Madhoun, A
   Al-Mulla, F
   Ahmad, R
   Sindhu, S
AF Akhter, Nadeem
   Wilson, Ajit
   Arefanian, Hossein
   Thomas, Reeby
   Kochumon, Shihab
   Al-Rashed, Fatema
   Abu-Farha, Mohamed
   Al-Madhoun, Ashraf
   Al-Mulla, Fahd
   Ahmad, Rasheed
   Sindhu, Sardar
TI Endoplasmic Reticulum Stress Promotes the Expression of TNF-α in THP-1
   Cells by Mechanisms Involving ROS/CHOP/HIF-1α and MAPK/NF-κB Pathways
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE ER stress; metabolic stress; obesity; metabolic syndrome; inflammation;
   TNF-alpha; ROS; CHOP; HIF-1 alpha; MAPK/NF-kappa B
ID TUMOR-NECROSIS-FACTOR; OXIDATIVE STRESS; ADIPOSE-TISSUE;
   INSULIN-RESISTANCE; FATTY-ACIDS; MONOCYTIC CELLS; UP-REGULATION;
   OLEIC-ACID; OBESITY; PROTEIN
AB Obesity and metabolic syndrome involve chronic low-grade inflammation called metabolic inflammation as well as metabolic derangements from increased endotoxin and free fatty acids. It is debated whether the endoplasmic reticulum (ER) stress in monocytic cells can contribute to amplify metabolic inflammation; if so, by which mechanism(s). To test this, metabolic stress was induced in THP-1 cells and primary human monocytes by treatments with lipopolysaccharide (LPS), palmitic acid (PA), or oleic acid (OA), in the presence or absence of the ER stressor thapsigargin (TG). Gene expression of tumor necrosis factor (TNF)-alpha and markers of ER/oxidative stress were determined by qRT-PCR, TNF-alpha protein by ELISA, reactive oxygen species (ROS) by DCFH-DA assay, hypoxia-inducible factor 1-alpha (HIF-1 alpha), p38, extracellular signal-regulated kinase (ERK)-1,2, and nuclear factor kappa B (NF-kappa B) phosphorylation by immunoblotting, and insulin sensitivity by glucose-uptake assay. Regarding clinical analyses, adipose TNF-alpha was assessed using qRT-PCR/IHC and plasma TNF-alpha, high-sensitivity C-reactive protein (hs-CRP), malondialdehyde (MDA), and oxidized low-density lipoprotein (OX-LDL) via ELISA. We found that the cooperative interaction between metabolic and ER stresses promoted TNF-alpha, ROS, CCAAT-enhancer-binding protein homologous protein (CHOP), activating transcription factor 6 (ATF6), superoxide dismutase 2 (SOD2), and nuclear factor erythroid 2-related factor 2 (NRF2) expression (p <= 0.0183),. However, glucose uptake was not impaired. TNF-alpha amplification was dependent on HIF-1 alpha stabilization and p38 MAPK/p65 NF-kappa B phosphorylation, while the MAPK/NF-kappa B pathway inhibitors and antioxidants/ROS scavengers such as curcumin, allopurinol, and apocynin attenuated the TNF-alpha production (p <= 0.05). Individuals with obesity displayed increased adipose TNF-alpha gene/protein expression as well as elevated plasma levels of TNF-alpha, CRP, MDA, and OX-LDL (p <= 0.05). Our findings support a metabolic-ER stress cooperativity model, favoring inflammation by triggering TNF-alpha production via the ROS/CHOP/HIF-1 alpha and MAPK/NF-kappa B dependent mechanisms. This study also highlights the therapeutic potential of antioxidants in inflammatory conditions involving metabolic/ER stresses.
C1 [Akhter, Nadeem; Wilson, Ajit; Arefanian, Hossein; Thomas, Reeby; Kochumon, Shihab; Al-Rashed, Fatema; Ahmad, Rasheed; Sindhu, Sardar] Dasman Diabet Inst, Dept Immunol & Microbiol, POB 1180, Dasman 15462, Kuwait.
   [Abu-Farha, Mohamed; Al-Mulla, Fahd] Dasman Diabet Inst, Dept Translat Res, POB 1180, Dasman 15462, Kuwait.
   [Al-Madhoun, Ashraf] Dasman Diabet Inst, Dept Genet & Bioinformat, POB 1180, Dasman 15462, Kuwait.
   [Al-Madhoun, Ashraf; Sindhu, Sardar] Dasman Diabet Inst, Anim & Imaging Core Facil, POB 1180, Dasman 15462, Kuwait.
C3 Dasman Diabetes Institute (DDI); Dasman Diabetes Institute (DDI); Dasman
   Diabetes Institute (DDI); Dasman Diabetes Institute (DDI)
RP Sindhu, S (corresponding author), Dasman Diabet Inst, Dept Immunol & Microbiol, POB 1180, Dasman 15462, Kuwait.; Sindhu, S (corresponding author), Dasman Diabet Inst, Anim & Imaging Core Facil, POB 1180, Dasman 15462, Kuwait.
EM nadeem.akhter@dasmaninstitute.org; ajit.wilson@dasmaninstitute.org;
   hossein.arefanian@dasmaninstitute.org; reeby.thomas@dasmaninstitute.org;
   shihab.kochumon@dasmaninstitute.org;
   fatema.alrashed@dasmaninstitute.org;
   mohamed.abufarha@dasmaninstitute.org;
   ashraf.madhoun@dasmaninstitute.org; fahd.almulla@dasmaninstitute.org;
   rasheed.ahmad@dasmaninstitute.org; sardar.sindhu@dasmaninstitute.org
RI Al Madhoun, Ashraf/I-3043-2012; Abu-Farha, Mohamed/KHW-8579-2024;
   Arefanian, Hossein/K-2422-2019; Ahmad, Rasheed/LMP-1937-2024; sindhu,
   sardar/ABE-3565-2021; Al-Mulla, Fahd/E-2068-2015
OI Alrashed, Fatema/0000-0003-4020-5978; Abu-Farha,
   Mohamed/0000-0001-8357-1252
FU We thank Valerie Lopez for PBMC isolation and Lubaina Koti for editorial
   assistance. The authors also thank the study participants.
FX We thank Valerie Lopez for PBMC isolation and Lubaina Koti for editorial
   assistance. The authors also thank the study participants.
CR Abreu RD, 2009, MOL BIOSYST, V5, P1512, DOI 10.1039/b908315d
   Ahmad Rasheed, 2019, Cell Physiol Biochem, V52, P908, DOI 10.33594/000000063
   Ahmad Rasheed, 2019, Cell Physiol Biochem, V52, P212, DOI 10.33594/000000015
   Akhter N, 2022, J INFLAMM RES, V15, P4291, DOI 10.2147/JIR.S368352
   Akhter N, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms221910519
   Bhandary B, 2013, INT J MOL SCI, V14, P434, DOI 10.3390/ijms14010434
   Biden TJ, 2014, TRENDS ENDOCRIN MET, V25, P389, DOI 10.1016/j.tem.2014.02.003
   Birben E, 2012, WORLD ALLERGY ORGAN, V5, P9, DOI 10.1097/WOX.0b013e3182439613
   Biswas SK, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/5698931
   Blühre M, 2009, EXP CLIN ENDOCR DIAB, V117, P241, DOI 10.1055/s-0029-1192044
   Boutagy NE, 2016, BIOCHIMIE, V124, P11, DOI 10.1016/j.biochi.2015.06.020
   Brooks GC, 2010, AM J CARDIOL, V106, P56, DOI 10.1016/j.amjcard.2010.02.017
   Cao SS, 2014, ANTIOXID REDOX SIGN, V21, P396, DOI 10.1089/ars.2014.5851
   Colak E, 2020, J MED BIOCHEM, V39, P346, DOI 10.2478/jomb-2019-0051
   Collins RA, 2001, J HISTOCHEM CYTOCHEM, V49, P989, DOI 10.1177/002215540104900807
   Couillard C, 2005, J CLIN ENDOCR METAB, V90, P6454, DOI 10.1210/jc.2004-2438
   Díaz-Bulnes P, 2020, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.02951
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   GAILLARD RC, 1990, ENDOCRINOLOGY, V127, P101, DOI 10.1210/endo-127-1-101
   Gomes RZ, 2016, ACTA CIR BRAS, V31, P126, DOI 10.1590/S0102-865020160020000007
   Grill V, 2000, BRIT J NUTR, V83, pS79
   Harte AL, 2012, DIABETES CARE, V35, P375, DOI 10.2337/dc11-1593
   Harvey KA, 2010, J LIPID RES, V51, P3470, DOI 10.1194/jlr.M010371
   Hasnain SZ, 2012, IMMUNOL CELL BIOL, V90, P260, DOI 10.1038/icb.2011.112
   Håversen L, 2009, ATHEROSCLEROSIS, V202, P382, DOI 10.1016/j.atherosclerosis.2008.05.033
   Higuchi M, 2013, STEM CELLS DEV, V22, P878, DOI 10.1089/scd.2012.0306
   HOTAMISLIGIL GS, 1994, DIABETES, V43, P1271, DOI 10.2337/diabetes.43.11.1271
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   HOTAMISLIGIL GS, 1995, J CLIN INVEST, V95, P2409, DOI 10.1172/JCI117936
   Hu P, 2006, MOL CELL BIOL, V26, P3071, DOI 10.1128/MCB.26.8.3071-3084.2006
   Hummasti S, 2010, CIRC RES, V107, P579, DOI 10.1161/CIRCRESAHA.110.225698
   Kasai S, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10020320
   KERN PA, 1995, J CLIN INVEST, V95, P2111, DOI 10.1172/JCI117899
   Lamers D, 2012, MOL CELL ENDOCRINOL, V362, P194, DOI 10.1016/j.mce.2012.06.010
   Lolmède K, 2003, INT J OBESITY, V27, P1187, DOI 10.1038/sj.ijo.0802407
   Maier T, 2009, FEBS LETT, V583, P3966, DOI 10.1016/j.febslet.2009.10.036
   Malhotra JD, 2007, SEMIN CELL DEV BIOL, V18, P716, DOI 10.1016/j.semcdb.2007.09.003
   Malhotra JD, 2007, ANTIOXID REDOX SIGN, V9, P2277, DOI 10.1089/ars.2007.1782
   Miyazaki Y, 2003, INT J OBESITY, V27, P88, DOI 10.1038/sj.ijo.0802187
   MOI P, 1994, P NATL ACAD SCI USA, V91, P9926, DOI 10.1073/pnas.91.21.9926
   Montgomery SL, 2012, J NEUROIMMUNE PHARM, V7, P42, DOI 10.1007/s11481-011-9287-2
   Mota M, 2016, METABOLISM, V65, P1049, DOI 10.1016/j.metabol.2016.02.014
   Mukhopadhyay S, 2006, RESP RES, V7, DOI 10.1186/1465-9921-7-125
   Musunuru K, 2008, NAT CLIN PRACT CARD, V5, P621, DOI 10.1038/ncpcardio1322
   Nakagawa H, 2014, CANCER CELL, V26, P331, DOI 10.1016/j.ccr.2014.07.001
   Nam SJ, 2014, CLIN EXP MED, V14, P261, DOI 10.1007/s10238-013-0241-x
   Nilsson J, 1998, ARTERIOSCL THROM VAS, V18, P1199, DOI 10.1161/01.ATV.18.8.1199
   Palomer X, 2018, TRENDS ENDOCRIN MET, V29, P178, DOI 10.1016/j.tem.2017.11.009
   Prázny M, 1999, CLIN CHEM LAB MED, V37, P1129, DOI 10.1515/CCLM.1999.164
   Qiu XL, 2010, CELL METAB, V12, P662, DOI 10.1016/j.cmet.2010.11.015
   RON D, 1992, GENE DEV, V6, P439, DOI 10.1101/gad.6.3.439
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Sage AT, 2010, AM J PHYSIOL-ENDOC M, V298, pE499, DOI 10.1152/ajpendo.00507.2009
   Sankhla M, 2012, CLIN LAB, V58, P385
   Sindhu S, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9081799
   Sindhu S, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9030730
   Sindhu S, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8111418
   Sindhu S, 2016, CELL PHYSIOL BIOCHEM, V39, P889, DOI 10.1159/000447798
   Sindhu S, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0133494
   Sindhu STAK, 2003, J VIROL, V77, P1848, DOI 10.1128/JVI.77.3.1848-1855.2003
   Ståhlman M, 2012, DIABETOLOGIA, V55, P1156, DOI 10.1007/s00125-011-2444-6
   Tu BP, 2004, J CELL BIOL, V164, P341, DOI 10.1083/jcb.200311055
   Uysal KT, 1997, NATURE, V389, P610, DOI 10.1038/39335
   Vogel C, 2012, NAT REV GENET, V13, P227, DOI 10.1038/nrg3185
   Wang B, 2007, PFLUG ARCH EUR J PHY, V455, P479, DOI 10.1007/s00424-007-0301-8
   Wang SL, 2009, BIOMED ENVIRON SCI, V22, P32, DOI 10.1016/S0895-3988(09)60019-2
   Weinbrenner T, 2006, AM J CLIN NUTR, V83, P30
   Wood IS, 2007, BIOCHEM BIOPH RES CO, V361, P468, DOI 10.1016/j.bbrc.2007.07.032
   Xiao K, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/5803639
   Ye J, 2009, INT J OBESITY, V33, P54, DOI 10.1038/ijo.2008.229
   Zelová H, 2013, INFLAMM RES, V62, P641, DOI 10.1007/s00011-013-0633-0
   Zhang HR, 2009, CLIN SCI, V116, P219, DOI 10.1042/CS20080196
   Zinman B, 1999, J CLIN ENDOCR METAB, V84, P272, DOI 10.1210/jc.84.1.272
NR 73
TC 23
Z9 26
U1 5
U2 12
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2023
VL 24
IS 20
AR 15186
DI 10.3390/ijms242015186
PG 26
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA X4BW7
UT WOS:001097933200001
PM 37894865
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Fang, CY
   Egleston, BL
   Gabriel, KP
   Stevens, VJ
   Kwiterovich, PO
   Snetselaar, LG
   Longacre, ML
   Dorgan, JF
AF Fang, Carolyn Y.
   Egleston, Brian L.
   Gabriel, Kelley Pettee
   Stevens, Victor J.
   Kwiterovich, Peter O., Jr.
   Snetselaar, Linda G.
   Longacre, Margaret L.
   Dorgan, Joanne F.
TI Depressive symptoms and serum lipid levels in young adult women
SO JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Depression; Cholesterol; Health behaviors; Diet
ID DENSITY-LIPOPROTEIN CHOLESTEROL; ARTERY RISK DEVELOPMENT; METABOLIC
   SYNDROME; LIFE-STYLE; DIETARY INTERVENTION; PHYSICAL-ACTIVITY; HEALTH
   BEHAVIORS; POLYMORPHISM; ASSOCIATION; MEDIATION
AB Accumulating data suggest that depression is associated with risk factors for cardiovascular disease, but few studies have investigated potential behavioral mediators of such associations, particularly among women. In this study of healthy young adult women (n = 225), we examined associations among depressive symptoms, health behaviors, and serum lipid levels. Depressive symptoms were assessed with the 20-item Center for Epidemiologic Studies-Depression scale, and a fasting blood sample was obtained for serum lipid levels, including total cholesterol, high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C). Diet was measured using 24-h recalls, and other health behaviors (physical activity, smoking) were assessed via self-report questionnaire. Results indicated a modest negative association between depressive symptoms and LDL-C levels. Higher levels of depressive symptoms were also associated with lower total and insoluble dietary fiber intake, both of which were associated with HDL-C and LDL-C. Mediational analyses indicated a significant indirect effect of depressive symptoms on LDL-C via total and insoluble dietary fiber in unadjusted analyses, but not in adjusted analyses. The present findings suggest that depressive symptoms are inversely associated with serum LDL-C levels in young adult women, but that these associations are not likely mediated by adverse lifestyle behaviors.
C1 [Fang, Carolyn Y.; Longacre, Margaret L.] Fox Chase Canc Ctr, Canc Prevent & Control Program, Philadelphia, PA 19111 USA.
   [Egleston, Brian L.] Fox Chase Canc Ctr, Dept Biostat & Bioinformat, Philadelphia, PA 19111 USA.
   [Gabriel, Kelley Pettee] Univ Texas Hlth Sci Ctr Houston, Div Epidemiol Human Genet & Environm Sci, Univ Texas Sch Publ Hlth Austin Reg Campus, Univ Texas Adm Bldg UTA, Austin, TX 78701 USA.
   [Stevens, Victor J.] Kaiser Permanente Ctr Hlth Res, Portland, OR 97227 USA.
   [Kwiterovich, Peter O., Jr.] Johns Hopkins Univ, Sch Med, Dept Pediat, Lipid Res Atherosclerosis Unit, Baltimore, MD 21287 USA.
   [Kwiterovich, Peter O., Jr.] Johns Hopkins Univ, Sch Med, Dept Med, Lipid Res Atherosclerosis Unit, Baltimore, MD 21287 USA.
   [Snetselaar, Linda G.] Univ Iowa, Coll Publ Hlth, Dept Epidemiol, Iowa City, IA 52242 USA.
   [Dorgan, Joanne F.] Fox Chase Canc Ctr, Womens Canc Program, Philadelphia, PA 19111 USA.
C3 Fox Chase Cancer Center; Fox Chase Cancer Center; University of Texas
   System; University of Texas Health Science Center Houston; Kaiser
   Permanente; Johns Hopkins University; Johns Hopkins University;
   University of Iowa; Fox Chase Cancer Center
RP Fang, CY (corresponding author), Fox Chase Canc Ctr, Canc Prevent & Control Program, Robert C Young Pavil,4th Floor,333 Cottman Ave, Philadelphia, PA 19111 USA.
EM carolyn.fang@fccc.edu; brian.egleston@fccc.edu;
   Kelley.P.Gabriel@uth.tmc.edu; victor.j.stevens@kpchr.org;
   pkwitero@jhmi.edu; linda-snetselaar@uiowa.edu;
   margaret.longacre@fccc.edu; joanne.dorgan@fccc.edu
RI Egleston, Brian/P-1000-2019; Fang, Carolyn/A-2324-2008
OI Egleston, Brian/0000-0002-1633-799X; Fang, Carolyn/0000-0002-0575-3867
CR Ainsworth BE, 2000, MED SCI SPORT EXER, V32, pS498, DOI 10.1097/00005768-200009001-00009
   [Anonymous], 1993, Ann Epidemiol, V3, P393, DOI 10.1016/1047-2797(93)90067-E
   [Anonymous], MED SCI SPORTS EXERC
   Brien SE, 2011, BMJ-BRIT MED J, V342, DOI 10.1136/bmj.d636
   Broms U, 2004, NICOTINE TOB RES, V6, P447, DOI 10.1080/14622200410001696637
   Carnethon MR, 2004, DIABETES CARE, V27, P2707, DOI 10.2337/diacare.27.11.2707
   CLEVIDENCE BA, 1995, ARTERIOSCL THROM VAS, V15, P179, DOI 10.1161/01.ATV.15.2.179
   DENKE MA, 1994, ARCH INTERN MED, V154, P401, DOI 10.1001/archinte.154.4.401
   Dorgan JF, 2010, CANCER EPIDEM BIOMAR, V19, P1545, DOI 10.1158/1055-9965.EPI-09-1259
   ENGELBERG H, 1992, LANCET, V339, P727, DOI 10.1016/0140-6736(92)90609-7
   Fischer P, 2006, MOL PSYCHIATR, V11, P707, DOI 10.1038/sj.mp.4001837
   FRIEDEWALD WT, 1972, CLIN CHEM, V18
   Galobardes B, 2001, INT J EPIDEMIOL, V30, P334, DOI 10.1093/ije/30.2.334
   Gary TL, 2000, DIABETES CARE, V23, P23, DOI 10.2337/diacare.23.1.23
   Georgiou CC, 1997, J AM DIET ASSOC, V97, P754, DOI 10.1016/S0002-8223(97)00187-9
   Golomb BA, 2004, CONTROL CLIN TRIALS, V25, P178, DOI 10.1016/j.cct.2003.08.014
   Gravely-Witte S, 2009, J BEHAV MED, V32, P478, DOI 10.1007/s10865-009-9218-3
   Gupta R, 2007, J Assoc Physicians India, V55, P621
   Harrell FE, 2001, Regression Modeling Strategies: With Applications to Linear Models, Logistic Regression, and Survival Analysis
   Horsten M, 1997, PSYCHOSOM MED, V59, P521, DOI 10.1097/00006842-199709000-00009
   Houston MC, 2009, PROG CARDIOVASC DIS, V52, P61, DOI 10.1016/j.pcad.2009.02.002
   Igna CV, 2008, PSYCHOSOM MED, V70, P960, DOI 10.1097/PSY.0b013e318189a942
   Imai K, 2010, PSYCHOL METHODS, V15, P309, DOI 10.1037/a0020761
   KAPLAN JR, 1994, PSYCHOSOM MED, V56, P479, DOI 10.1097/00006842-199411000-00001
   Katcher HI, 2009, ENDOCRIN METAB CLIN, V38, P45, DOI 10.1016/j.ecl.2008.11.010
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   KOHLMEIER M, 1986, CLIN CHEM, V32, P63
   KRISKA AM, 1990, DIABETES CARE, V13, P401, DOI 10.2337/diacare.13.4.401
   Lamb KA, 2003, J MARRIAGE FAM, V65, P953, DOI 10.1111/j.1741-3737.2003.00953.x
   Leach LS, 2008, SOC PSYCH PSYCH EPID, V43, P983, DOI 10.1007/s00127-008-0388-z
   Lee S, 2005, INT J EPIDEMIOL, V34, P69, DOI 10.1093/ije/dyh258
   Lett HS, 2004, PSYCHOSOM MED, V66, P305, DOI 10.1097/01.psy.0000126207.43307.c0
   López-León S, 2008, MOL PSYCHIATR, V13, P772, DOI 10.1038/sj.mp.4002088
   López-León S, 2010, J AFFECT DISORDERS, V122, P247, DOI 10.1016/j.jad.2009.07.008
   Markovitz JH, 1997, ARCH INTERN MED, V157, P1953, DOI 10.1001/archinte.157.17.1953
   Martinez-Gonzalez MA, 1998, EUR J EPIDEMIOL, V14, P525, DOI 10.1023/A:1007402521913
   Matsuzaki Y., 1996, J Anal Bio-Sc, V19, P419
   McCaffery JM, 2003, PSYCHOSOM MED, V65, P490, DOI 10.1097/01.PSY.0000041545.52924.82
   Obarzanek E, 1997, PEDIATRICS, V100, P51, DOI 10.1542/peds.100.1.51
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Schakel Sally F., 1997, Journal of Food Composition and Analysis, V10, P102, DOI 10.1006/jfca.1997.0527
   Schoenborn Charlotte A, 2004, Adv Data, P1
   Schubert CM, 2006, INT J OBESITY, V30, P251, DOI 10.1038/sj.ijo.0803129
   Schulz L O, 1994, Obes Res, V2, P541
   Shin JY, 2008, ANN BEHAV MED, V36, P33, DOI 10.1007/s12160-008-9045-8
   Shrivastava S, 2010, BIOCHEMISTRY-US, V49, P5426, DOI 10.1021/bi100276b
   Shrout PE, 2002, PSYCHOL METHODS, V7, P422, DOI 10.1037//1082-989X.7.4.422
   SIEDEL J, 1983, CLIN CHEM, V29, P1075
   Steegmans PHA, 1996, BRIT MED J, V312, P221, DOI 10.1136/bmj.312.7025.221
   Suarez EC, 1999, PSYCHOSOM MED, V61, P273, DOI 10.1097/00006842-199905000-00004
   SUGIUCHI H, 1995, CLIN CHEM, V41, P717
   Tomson K, 2011, PROG NEURO-PSYCHOPH, V35, P1857, DOI 10.1016/j.pnpbp.2011.08.004
   Trost SG, 2002, MED SCI SPORT EXER, V34, P350, DOI 10.1097/00005768-200202000-00025
   Tsuboi H, 2006, J AFFECT DISORDERS, V91, P63, DOI 10.1016/j.jad.2005.12.010
   Vogelzangs N, 2007, PSYCHONEUROENDOCRINO, V32, P151, DOI 10.1016/j.psyneuen.2006.11.009
   Whooley MA, 2008, JAMA-J AM MED ASSOC, V300, P2379, DOI 10.1001/jama.2008.711
   Williams RL, 2000, BIOMETRICS, V56, P645, DOI 10.1111/j.0006-341X.2000.00645.x
   Wood R.G., 2007, EFFECTS MARRIAGE HLT
   Wulsin LR, 2003, PSYCHOSOM MED, V65, P201, DOI 10.1097/01.PSY.0000058371.50240.E3
   Yamamoto Akira, 2003, J Atheroscler Thromb, V10, P176
NR 60
TC 27
Z9 30
U1 0
U2 20
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0160-7715
EI 1573-3521
J9 J BEHAV MED
JI J. Behav. Med.
PD APR
PY 2013
VL 36
IS 2
BP 143
EP 152
DI 10.1007/s10865-012-9409-1
PG 10
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA 109RG
UT WOS:000316385600004
PM 22382824
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Anderson, RE III
   Graham, KA
AF Anderson III, Robert E.
   Graham, Karen A.
TI North Carolina Healthy Active Living: Describing a Wellness Coaching
   Program for First-Episode Psychosis Clinics
SO AMERICAN JOURNAL OF LIFESTYLE MEDICINE
LA English
DT Article; Early Access
DE first-episode psychosis; coordinated specialty care; psychosis;
   lifestyle interventions
ID LIFE-STYLE INTERVENTIONS; SOCIAL COGNITIVE THEORY; INDUCED WEIGHT-GAIN;
   PHYSICAL-ACTIVITY; SEDENTARY BEHAVIOR; METABOLIC SYNDROME;
   MENTAL-ILLNESS; BLOOD-PRESSURE; OBESE ADULTS; SCHIZOPHRENIA
AB Cardiovascular disease presents a ten-fold higher risk of death than suicide in individuals with serious mental illness. Individuals experiencing first-episode psychosis already have high rates of modifiable risk factors contributing to cardiovascular disease. The initial 12 months are crucial for implementing behavioral interventions for effective risk factor modification and disease prevention. Coordinated Specialty Care (CSC) outpatient clinics provide multi-disciplinary team-based treatment for teens and young adults in the early stages of psychotic illness, significantly improving mental health outcomes and quality of life. However, these clinics lack support for addressing lifestyle behavior changes in their clients. The North Carolina Healthy Active Living (NC HeAL) program is an innovative clinical service offered to all CSC clients in this state. It offers personalized health and wellness coaching to help clients achieve meaningful health improvements. This paper provides a detailed description of the program's development, the target population and setting, the roles and skills of the NC HeAL team, program components and evidence-based program measures. Results of program measures, feasibility, acceptability, implementation, and fidelity will be published separately.
C1 [Anderson III, Robert E.] Univ North Carolina Chapel Hill, Gillings Sch Global Publ Hlth, Dept Nutr, Chapel Hill, NC USA.
   [Graham, Karen A.] Univ North Carolina Chapel Hill, Dept Psychiat, 101 Manning Dr 1, Chapel Hill, NC 27514 USA.
C3 University of North Carolina School of Medicine; University of North
   Carolina; University of North Carolina Chapel Hill; University of North
   Carolina; University of North Carolina Chapel Hill; University of North
   Carolina School of Medicine
RP Graham, KA (corresponding author), Univ North Carolina Chapel Hill, Dept Psychiat, 101 Manning Dr 1, Chapel Hill, NC 27514 USA.
EM karen_graham@med.unc.edu
OI Anderson III, Robert E./0000-0002-0008-7754
FU NC Division of MHDDSA; NC First-Episode Psychosis Coordinated Specialty
   Care (NC-CSC) Programs; Federal Community Mental Health Services Block
   Grant (CFDA) [93.958]
FX The author(s) disclosed receipt of the followingfinancialsupport for the
   research, authorship, and/or publicationof this article: Early Psychosis
   Interventions of North Carolina (EPI-NC) is funded by the NC Division of
   MHDDSA and supports NC First-Episode Psychosis Coordinated Specialty
   Care (NC-CSC) Programs.Federal Community Mental Health Services Block
   Grant(CFDA #93.958).
CR Alvarez-Jiménez M, 2008, BRIT J PSYCHIAT, V193, P101, DOI 10.1192/bjp.bp.107.042853
   Alvarez-Jiménez M, 2006, J CLIN PSYCHIAT, V67, P1253, DOI 10.4088/JCP.v67n0812
   Alvarez-Jiménez M, 2010, SCHIZOPHR RES, V116, P16, DOI 10.1016/j.schres.2009.10.012
   Armstrong Marni, 2018, Transl J Am Coll Sports Med, V3, P176, DOI 10.1249/TJX.0000000000000073
   Aucott L, 2011, OBES REV, V12, pe412, DOI 10.1111/j.1467-789X.2010.00819.x
   Bagherniya M, 2018, HEALTH EDUC RES, V33, P26, DOI 10.1093/her/cyx079
   Bandura A, 2001, ANNU REV PSYCHOL, V52, P1, DOI 10.1146/annurev.psych.52.1.1
   Bandura A., 1986, Social foundations of thought and action: A social cognitive theory, DOI DOI 10.5465/AMR.1987.4306538
   Bazzano LA, 2013, CURR HYPERTENS REP, V15, P694, DOI 10.1007/s11906-013-0390-z
   Breitborde NJK, 2009, EARLY INTERV PSYCHIA, V3, P259, DOI 10.1111/j.1751-7893.2009.00148.x
   Brown T, 2015, HARVARD BUS REV, V93, P57
   Carey RN, 2019, ANN BEHAV MED, V53, P693, DOI 10.1093/abm/kay078
   Coentre R, 2022, J INT MED RES, V50, DOI 10.1177/03000605221106703
   Connell LE, 2019, ANN BEHAV MED, V53, P708, DOI 10.1093/abm/kay082
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   Correll CU, 2015, WORLD PSYCHIATRY, V14, P119, DOI 10.1002/wps.20204
   Correll CU, 2014, JAMA PSYCHIAT, V71, P1350, DOI 10.1001/jamapsychiatry.2014.1314
   Corrigan PW, 2005, ON THE STIGMA OF MENTAL ILLNESS: PRACTICAL STRATEGIES FOR RESEARCH AND SOCIAL CHANGE, P11, DOI 10.1037/10887-001
   Craig C., 2017, Journal of American College Health, V65, P492
   Cruz BD, 2022, JAMA INTERN MED, V182, P1139, DOI 10.1001/jamainternmed.2022.4000
   Davy BM, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0172610
   de Vries HJ, 2016, OBESITY, V24, P2078, DOI 10.1002/oby.21619
   Dipasquale S, 2013, J PSYCHIATR RES, V47, P197, DOI 10.1016/j.jpsychires.2012.10.005
   Elwyn G, 2012, J GEN INTERN MED, V27, P1361, DOI 10.1007/s11606-012-2077-6
   Ettehad D, 2016, LANCET, V387, P957, DOI 10.1016/S0140-6736(15)01225-8
   Fagerström K, 2012, NICOTINE TOB RES, V14, P1467, DOI 10.1093/ntr/nts018
   Firth J, 2020, WORLD PSYCHIATRY, V19, P360, DOI 10.1002/wps.20773
   Firth J, 2019, LANCET PSYCHIAT, V6, P675, DOI 10.1016/S2215-0366(19)30132-4
   Firth J, 2018, EARLY INTERV PSYCHIA, V12, P307, DOI 10.1111/eip.12329
   Gottgens Irene, 2021, JMIR Mhealth Uhealth, V9, pe28102, DOI 10.2196/28102
   Gurusamy J, 2018, ASIAN J PSYCHIATR, V36, P73, DOI 10.1016/j.ajp.2018.06.018
   Hall KS, 2020, INT J BEHAV NUTR PHY, V17, DOI 10.1186/s12966-020-00978-9
   Hall KD, 2018, MED CLIN N AM, V102, P183, DOI 10.1016/j.mcna.2017.08.012
   Harsha DW, 2008, HYPERTENSION, V51, P1420, DOI 10.1161/HYPERTENSIONAHA.107.094011
   He JA, 2000, HYPERTENSION, V35, P544, DOI 10.1161/01.HYP.35.2.544
   Heald AH, 2023, CARDIOVASC ENDOCR ME, V12, DOI 10.1097/XCE.0000000000000286
   Islam KF, 2023, HELIYON, V9, DOI 10.1016/j.heliyon.2023.e14889
   Jakobsen AS, 2018, SCHIZOPHR RES, V199, P109, DOI 10.1016/j.schres.2018.03.016
   Janney CA, 2013, SCHIZOPHR RES, V145, P63, DOI 10.1016/j.schres.2013.01.010
   Jordan M., 2015, National Training and Education Standards for Health and Wellness Coaching: The Path to National Certification
   Kaiafa G, 2021, POSTGRAD MED J, V97, P380, DOI 10.1136/postgradmedj-2020-138756
   Kandzari DE, 2022, CIRCULATION, V145, P847, DOI 10.1161/CIRCULATIONAHA.121.057687
   Kane JM, 2015, J CLIN PSYCHIAT, V76, P240, DOI 10.4088/JCP.14m09289
   Cheung KL, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4902-7
   Keyserling TC, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-3370-9
   Khurana T, 2022, J PEDIATR-US, V250, P61, DOI 10.1016/j.jpeds.2022.07.004
   Kleiman EM, 2023, ASSESSMENT, V30, P2223, DOI 10.1177/10731911221146341
   Knol LL, 2016, AM J HEALTH EDUC, V47, P204, DOI 10.1080/19325037.2016.1179607
   Kraus WE, 2019, MED SCI SPORT EXER, V51, P1206, DOI 10.1249/MSS.0000000000001932
   Lisi DM, 2018, US PHARM, V43, P15
   Luszczynska A., 2015, Fac Health Sci Publ, P225, DOI DOI 10.1007/978-3-319-19715-511
   Melles M, 2021, INT J QUAL HEALTH C, V33, P37, DOI 10.1093/intqhc/mzaa127
   Mueser KT, 2015, PSYCHIAT SERV, V66, P680, DOI 10.1176/appi.ps.201400413
   Mueser KT., 2014, Rising to the challenge of first episode psychosis: the NIMH Recovery after Initial Schizophrenia Episode (RAISE) initiative
   Myles N, 2012, J CLIN PSYCHIAT, V73, P468, DOI 10.4088/JCP.11r07222
   Naous E, 2023, NUTRIENTS, V15, DOI 10.3390/nu15163661
   Naslund JA, 2017, GEN HOSP PSYCHIAT, V47, P83, DOI 10.1016/j.genhosppsych.2017.04.003
   Neff AJ, 2021, ARCH PHYS MED REHAB, V102, P395, DOI 10.1016/j.apmr.2020.08.007
   Nuttall Frank Q, 2015, Nutr Today, V50, P117
   Olfson M, 2015, JAMA PSYCHIAT, V72, P1172, DOI 10.1001/jamapsychiatry.2015.1737
   Org I., 2015, The Field Guide to Human Centered Design
   Pérez-Iglesias R, 2014, INT J NEUROPSYCHOPH, V17, P41, DOI 10.1017/S1461145713001053
   Plotnikoff RC, 2013, PREV MED, V56, P245, DOI 10.1016/j.ypmed.2013.01.013
   Rodrigues F, 2023, EDUC SCI, V13, DOI 10.3390/educsci13020122
   Saari KM, 2005, J CLIN PSYCHIAT, V66, P559, DOI 10.4088/JCP.v66n0503
   Scheid JL, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16173124
   Schlegel-Pratt K, 1990, Nutr Clin Pract, V5, P254, DOI 10.1177/0115426590005006254
   Schröder H, 2011, J NUTR, V141, P1140, DOI 10.3945/jn.110.135566
   Sebastian AT, 2021, HEALTH PSYCHOL RES, V9, DOI 10.52965/001c.24510
   Shamizadeh T, 2019, TRIALS, V20, DOI 10.1186/s13063-019-3220-z
   Shannon A, 2020, PSYCHIAT RES, V293, DOI 10.1016/j.psychres.2020.113402
   SHERBOURNE CD, 1991, SOC SCI MED, V32, P705, DOI 10.1016/0277-9536(91)90150-B
   Shern D., 2020, Issue brief financing coordinated specialty care for first episode psychosis: a clinician/advocate's guide
   THOMAS S, 1992, CAN J SPORT SCI, V17, P338
   Towle A, 1999, BRIT MED J, V319, P766, DOI 10.1136/bmj.319.7212.766
   UNC Center for Health Promotion and Disease Prevention, Med-South Lifestyle Program
   Valentiner LS, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0208181
   Vancampfort D, 2017, WORLD PSYCHIATRY, V16, P308, DOI 10.1002/wps.20458
   Ventriglio A, 2015, FRONT NEUROSCI-SWITZ, V9, DOI 10.3389/fnins.2015.00297
   West R, 2007, ADDICTION, V102, P506, DOI 10.1111/j.1360-0443.2007.01750.x
   Whelton Paul K, 2018, J Am Coll Cardiol, V71, pe127, DOI 10.1016/j.jacc.2017.11.006
   Wolever RQ, 2016, BMC HEALTH SERV RES, V16, DOI 10.1186/s12913-016-1465-8
   World Health Organization, 2018, Management of physical health conditions in adults with severe mental disorders WHO GUIDELINES Internet
NR 83
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1559-8276
EI 1559-8284
J9 AM J LIFESTYLE MED
JI Am. J. Lifestyle Med.
PD 2025 APR 10
PY 2025
DI 10.1177/15598276251331854
EA APR 2025
PG 9
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA 1FX6F
UT WOS:001464078900001
PM 40224299
DA 2025-06-11
ER

PT J
AU Mantzorou, M
   Pavlidou, E
   Vasios, G
   Tsagalioti, E
   Giaginis, C
AF Mantzorou, Maria
   Pavlidou, Eleni
   Vasios, George
   Tsagalioti, Eftychia
   Giaginis, Constantinos
TI Effects of curcumin consumption on human chronic diseases: A narrative
   review of the most recent clinical data
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE cancer; chronic diseases; curcumin; diabetes; inflammation; metabolic
   syndrome; obesity
ID MAJOR DEPRESSIVE DISORDER; HIGHLY-BIOAVAILABLE CURCUMIN;
   INFLAMMATORY-BOWEL-DISEASE; FATTY LIVER-DISEASE; DOUBLE-BLIND; PHASE-I;
   ULCERATIVE-COLITIS; ORAL CURCUMIN; CHEMOPREVENTIVE AGENT; KNEE
   OSTEOARTHRITIS
AB Numerous clinical trials have investigated the potential beneficial effects of curcumin supplementation against several human chronic diseases. Up to now, it has been claimed that curcumin consumption may exert beneficial effects against several chronic diseases by promoting human health and preventing diseases. In this aspect, the present review aims to critically collect and in-depth summarize the most recent, well-designed clinical studies evaluating the potential beneficial effects of curcumin consumption on human health promotion and disease prevention. According to recent and well-designed clinical studies, curcumin consumption may benefit against obesity, metabolic syndrome, and diabetes. Moreover, curcumin consumption seems to exert a positive effect on people suffering from various types of cancer, fatty liver disease, depression, arthritis, skin diseases, gut inflammation, and symptoms of premenstrual syndrome. Due to the strong heterogeneity among the clinical studies concerning the exact effective curcumin dose and formulation, as well as the recommended treatment duration for each chronic disease, no precise and definitive conclusions could be drawn. Further large-scale prospective studies are strongly recommended, being well-designed as far as follow-up times, dosage, formulation, and duration of curcumin supplementation are concerned. Moreover, potential confounders in each specific chronic disease should carefully be taken into account in future studies.
C1 [Mantzorou, Maria; Pavlidou, Eleni; Vasios, George; Tsagalioti, Eftychia; Giaginis, Constantinos] Univ Aegean, Sch Environm, Dept Food Sci & Nutr, Myrina, Lemnos, Greece.
RP Mantzorou, M (corresponding author), Univ Aegean, Dept Food Sci & Nutr, Mitropoliti Ioakim 2, Myrina 81440, Lemnos, Greece.
EM mantzorou.m@aegean.gr
RI Giaginis, Constantinos/JMQ-9552-2023; Pavlidou, Eleni/JMB-5502-2023
OI Pavlidou, Eleni/0000-0002-7764-3544; Mantzorou,
   Maria/0000-0002-2535-2841; Giaginis, Constantinos/0000-0003-2878-4831
CR Akazawa N, 2012, NUTR RES, V32, P795, DOI 10.1016/j.nutres.2012.09.002
   Al-Karawi D, 2016, PHYTOTHER RES, V30, P175, DOI 10.1002/ptr.5524
   Alwi Idrus, 2008, Acta Med Indones, V40, P201
   Andrew R, 2017, BRIT J PHARMACOL, V174, P1177, DOI 10.1111/bph.13779
   [Anonymous], 2016, HerbalGram
   Antiga E, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/283634
   Antony B, 2008, INDIAN J PHARM SCI, V70, P445, DOI 10.4103/0250-474X.44591
   Appelboom Thierry, 2014, Open Rheumatol J, V8, P77, DOI 10.2174/1874312901408010077
   Appendino G, 2011, Panminerva Med, V53, P43
   Appendino G., 2012, Panminerva Med, V54, P11
   Atkin SL, 2017, PHYTOTHER RES, V31, P1836, DOI 10.1002/ptr.5905
   Bayet-Robert M, 2010, CANCER BIOL THER, V9, P8, DOI 10.4161/cbt.9.1.10392
   Belcaro G, 2010, PANMINERVA MED, V52, P269
   Belcaro G, 2010, ALTERN MED REV, V15, P337
   Bergman J, 2013, CLIN NEUROPHARMACOL, V36, P73, DOI 10.1097/WNF.0b013e31828ef969
   Braga MEM, 2003, J AGR FOOD CHEM, V51, P6604, DOI 10.1021/jf0345550
   Chandran B, 2012, PHYTOTHER RES, V26, P1719, DOI 10.1002/ptr.4639
   Cheng AL, 2001, ANTICANCER RES, V21, P2895
   Cho JA, 2015, NUTR RES PRACT, V9, P117, DOI 10.4162/nrp.2015.9.2.117
   Chuengsamarn S, 2012, DIABETES CARE, V35, P2121, DOI 10.2337/dc12-0116
   Darvesh AS, 2012, CURR PHARM BIOTECHNO, V13, P218
   de Oliveira MR, 2016, BIOTECHNOL ADV, V34, P813, DOI 10.1016/j.biotechadv.2016.04.004
   Demmers A, 2017, DIABETES RES CLIN PR, V131, P91, DOI 10.1016/j.diabres.2017.05.024
   Dhillon N, 2008, CLIN CANCER RES, V14, P4491, DOI 10.1158/1078-0432.CCR-08-0024
   Douglass BJ, 2015, J AM COLL NUTR, V34, P347, DOI 10.1080/07315724.2014.950392
   Epelbaum R, 2010, NUTR CANCER, V62, P1137, DOI 10.1080/01635581.2010.513802
   Esmaily H, 2015, CHIN J INTEGR MED, V21, P332, DOI 10.1007/s11655-015-2160-z
   Feng T, 2017, INT J NANOMED, V12, P6027, DOI 10.2147/IJN.S132434
   Franco-Robles E, 2014, APPL PHYSIOL NUTR ME, V39, P211, DOI 10.1139/apnm-2013-0133
   Ganjali S, 2014, SCI WORLD J, DOI 10.1155/2014/898361
   Garcea G, 2005, CANCER EPIDEM BIOMAR, V14, P120
   Golombick T, 2012, AM J HEMATOL, V87, P455, DOI 10.1002/ajh.23159
   Golombick T, 2009, CLIN CANCER RES, V15, P5917, DOI 10.1158/1078-0432.CCR-08-2217
   Gota VS, 2010, J AGR FOOD CHEM, V58, P2095, DOI 10.1021/jf9024807
   Gupta SC, 2013, AAPS J, V15, P195, DOI 10.1208/s12248-012-9432-8
   Hanai H, 2006, CLIN GASTROENTEROL H, V4, P1502, DOI 10.1016/j.cgh.2006.08.008
   He ZY, 2011, CANCER INVEST, V29, P208, DOI 10.3109/07357907.2010.550592
   Henrotin Y, 2014, BMC COMPLEM ALTERN M, V14, DOI 10.1186/1472-6882-14-159
   Holt PR, 2005, DIGEST DIS SCI, V50, P2191, DOI 10.1007/s10620-005-3032-8
   Jäger R, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-11
   Kanai M, 2013, CANCER CHEMOTH PHARM, V71, P1521, DOI 10.1007/s00280-013-2151-8
   Kanai M, 2012, CANCER CHEMOTH PHARM, V69, P65, DOI 10.1007/s00280-011-1673-1
   Kanai M, 2011, CANCER CHEMOTH PHARM, V68, P157, DOI 10.1007/s00280-010-1470-2
   Khayat S, 2015, COMPLEMENT THER MED, V23, P318, DOI 10.1016/j.ctim.2015.04.001
   Kunnumakkara AB, 2017, BRIT J PHARMACOL, V174, P1325, DOI 10.1111/bph.13621
   Kurd SK, 2008, J AM ACAD DERMATOL, V58, P625, DOI 10.1016/j.jaad.2007.12.035
   Lal B, 1999, PHYTOTHER RES, V13, P318, DOI 10.1002/(SICI)1099-1573(199906)13:4<318::AID-PTR445>3.0.CO;2-7
   Lang A, 2015, CLIN GASTROENTEROL H, V13, P1444, DOI 10.1016/j.cgh.2015.02.019
   Langhorst J, 2015, J CROHNS COLITIS, V9, P86, DOI 10.1093/ecco-jcc/jju007
   Lopresti AL, 2015, EUR NEUROPSYCHOPHARM, V25, P38, DOI 10.1016/j.euroneuro.2014.11.015
   Lopresti AL, 2014, J AFFECT DISORDERS, V167, P368, DOI 10.1016/j.jad.2014.06.001
   Mahammedi H, 2016, ONCOLOGY-BASEL, V90, P69, DOI 10.1159/000441148
   Milani A, 2017, BRIT J PHARMACOL, V174, P1290, DOI 10.1111/bph.13625
   Moura MD, 2017, PHYTOTHER RES, V31, P1676, DOI 10.1002/ptr.5910
   Nabavi SF, 2014, COMPR REV FOOD SCI F, V13, P62, DOI 10.1111/1541-4337.12047
   Nakagawa Y, 2014, J ORTHOP SCI, V19, P933, DOI 10.1007/s00776-014-0633-0
   Neerati P, 2014, PHYTOTHER RES, V28, P1796, DOI 10.1002/ptr.5201
   Onakpoya IJ, 2017, INT J RHEUM DIS, V20, P420, DOI 10.1111/1756-185X.13069
   Panahi Y, 2017, DRUG RES, V67, P244, DOI 10.1055/s-0043-100019
   Panahi Y, 2012, ANN CLIN BIOCHEM, V49, P580, DOI 10.1258/acb.2012.012040
   Panahi Y, 2012, BRIT J NUTR, V108, P1272, DOI 10.1017/S0007114511006544
   Perrone D, 2015, EXP THER MED, V10, P1615, DOI 10.3892/etm.2015.2749
   Rahmani S, 2016, PHYTOTHER RES, V30, P1540, DOI 10.1002/ptr.5659
   RAVINDRANATH V, 1981, TOXICOLOGY, V20, P251, DOI 10.1016/0300-483X(81)90056-1
   Ryan JL, 2013, RADIAT RES, V180, P34, DOI 10.1667/RR3255.1
   Sanmukhani J, 2014, PHYTOTHER RES, V28, P579, DOI 10.1002/ptr.5025
   Schiborr C, 2014, MOL NUTR FOOD RES, V58, P516, DOI 10.1002/mnfr.201300724
   Schneider A, 2017, COMPLEMENT THER MED, V33, P32, DOI 10.1016/j.ctim.2017.06.002
   Sharma RA, 2004, CLIN CANCER RES, V10, P6847, DOI 10.1158/1078-0432.CCR-04-0744
   Singla V, 2014, J CROHNS COLITIS, V8, P208, DOI 10.1016/j.crohns.2013.08.006
   Siviero A, 2015, J HERB MED, V5, P57, DOI 10.1016/j.hermed.2015.03.001
   Stanic Z, 2012, CURCUMIN BIOSYNTHESI, P39
   Stanic Z, 2017, PLANT FOOD HUM NUTR, V72, P1, DOI 10.1007/s11130-016-0590-1
   Sugawara J, 2012, AM J HYPERTENS, V25, P651, DOI 10.1038/ajh.2012.24
   Suskind DL, 2013, J PEDIATR GASTR NUTR, V56, P277, DOI 10.1097/MPG.0b013e318276977d
   Vaughn AR, 2016, PHYTOTHER RES, V30, P1243, DOI 10.1002/ptr.5640
   Wang J, 2017, AM J PHYSIOL-CELL PH, V312, pC438, DOI 10.1152/ajpcell.00235.2016
   WHO, 1999, SEL MED PLANTS
   Yang H, 2015, EXP CLIN ENDOCR DIAB, V123, P360, DOI 10.1055/s-0035-1545345
   Yang KY, 2007, J CHROMATOGR B, V853, P183, DOI 10.1016/j.jchromb.2007.03.010
   Yang Y, 2015, PHARMACOL RES, V95-96, P71, DOI 10.1016/j.phrs.2015.03.016
   Yang YS, 2014, PHYTOTHER RES, V28, P1770, DOI 10.1002/ptr.5197
   Yu JJ, 2015, J CLIN PSYCHOPHARM, V35, P406, DOI 10.1097/JCP.0000000000000352
   Yu YC, 2015, METAB BRAIN DIS, V30, P47, DOI 10.1007/s11011-014-9554-z
   Yue GGL, 2012, J MED FOOD, V15, P242, DOI 10.1089/jmf.2011.1845
   Yue GGL, 2010, FOOD CHEM TOXICOL, V48, P2011, DOI 10.1016/j.fct.2010.04.039
NR 86
TC 100
Z9 108
U1 0
U2 62
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD JUN
PY 2018
VL 32
IS 6
BP 957
EP 975
DI 10.1002/ptr.6037
PG 19
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GI4TL
UT WOS:000434364000001
PM 29468820
DA 2025-06-11
ER

PT J
AU Bhasin, S
   Enzlin, P
   Coviello, A
   Basson, R
AF Bhasin, Shalender
   Enzlin, Paul
   Coviello, Andrea
   Basson, Rosemary
TI Sexual dysfunction 3 - Sexual dysfunction in men and women with
   endocrine disorders
SO LANCET
LA English
DT Review
ID QUALITY-OF-LIFE; SURGICALLY MENOPAUSAL WOMEN; TESTOSTERONE REPLACEMENT
   THERAPY; CONGENITAL ADRENAL-HYPERPLASIA; BENIGN PROSTATIC HYPERPLASIA;
   POLYCYSTIC-OVARY-SYNDROME; ERECTILE DYSFUNCTION; METABOLIC SYNDROME;
   ANDROGEN LEVELS; DESIRE DISORDER
AB Endocrine disease frequently interrupts sexual function, and sexual dysfunction may signal serious endocrine disease. Diabetic autonomic neuropathy and endothelial dysfunction impair erectile function, and phosphodiesterase inhibition produces only moderate benefit. The effect of diabetes on women's sexual function is complex: the most consistent finding is a correlation between sexual dysfunction and depression. Reductions in testosterone level in men are associated with low sexual desire and reduced nocturnal erections and ejaculate volume, all of which improve with testosterone supplementation. The age-dependent decline in testosterone production in men is not associated with precise sexual symptoms, and supplementation has not been shown to produce sexual benefit. In women, sexual dysfunction has not been associated with serum testosterone, but this may be confounded by limitations of assays at low concentrations and by the greater importance of intracellular production of testosterone in women than in men. Testosterone supplementation after menopause does improve some aspects of sexual function in women, but long-term outcome data are needed. More research on the sexual effects of abnormal adrenal and thyroid function, hyperprolactinaemia, and metabolic syndrome should also be prioritised. We have good data on local management of the genital consequences of oestrogen lack, but need to better understand the potential role of systemic oestrogen supplementation from menopause onwards in sexually symptomatic women.
C1 Boston Univ, Sch Med, Boston Med Ctr, Sect Endocrinol Diabet & Nutr, Boston, MA 02199 USA.
   Catholic Univ Louvain, Inst Family & Sexuality Studies, B-3000 Louvain, Belgium.
   Univ Hosp Gasthuisberg, Dept Psychiat, B-3000 Louvain, Belgium.
   Univ Hosp Gasthuisberg, Dept Gynaecol, B-3000 Louvain, Belgium.
   Univ British Columbia, Dept Psychiat, Vancouver, BC V5Z 1M9, Canada.
   Univ British Columbia, Dept Obstet & Gynecol, Vancouver, BC V5Z 1M9, Canada.
   Univ British Columbia, BC Ctr Sexual Med, Vancouver, BC V5Z 1M9, Canada.
   Univ British Columbia, Vancouver Gen Hosp, Vancouver, BC V5Z 1M9, Canada.
C3 Boston Medical Center; Boston University; Universite Catholique Louvain;
   KU Leuven; University Hospital Leuven; KU Leuven; University Hospital
   Leuven; University of British Columbia; University of British Columbia;
   University of British Columbia; University of British Columbia
RP Bhasin, S (corresponding author), Boston Univ, Sch Med, Boston Med Ctr, Sect Endocrinol Diabet & Nutr, Boston, MA 02199 USA.
EM bhasin@bu.edu
RI Enzlin, Paul/AAW-3160-2020
OI Enzlin, Paul/0000-0002-6641-5159; Coviello, Andrea/0000-0003-0244-9787
CR Alexander GM, 1997, HORM BEHAV, V31, P110, DOI 10.1006/hbeh.1997.1372
   Althof SE, 2005, J SEX MED, V2, P146, DOI 10.1111/j.1743-6109.2005.00130.x
   Anderson RA, 1999, J CLIN ENDOCR METAB, V84, P3556, DOI 10.1210/jc.84.10.3556
   Angulo J, 2003, BIOCHEM BIOPH RES CO, V312, P1202, DOI 10.1016/j.bbrc.2003.11.034
   [Anonymous], 2005, MENOPAUSE, V12, P497, DOI 10.1097/01.gme.0000177709.65944.b0
   Apperloo M, 2006, J SEX MED, V3, P541, DOI 10.1111/j.1743-6109.2006.00212.x
   Archer JS, 2006, MENOPAUSE, V13, P528, DOI 10.1097/01.gme.0000188737.46746.cd
   Arlt W, 1999, NEW ENGL J MED, V341, P1013, DOI 10.1056/NEJM199909303411401
   Arver S, 1996, J UROLOGY, V155, P1604, DOI 10.1016/S0022-5347(01)66141-X
   Aziz A, 2005, FERTIL STERIL, V83, P1021, DOI 10.1016/j.fertnstert.2004.12.008
   Bachmann G, 2002, FERTIL STERIL, V77, P660, DOI 10.1016/S0015-0282(02)02969-2
   BAGATELL CJ, 1994, J CLIN ENDOCR METAB, V78, P711, DOI 10.1210/jc.78.3.711
   Bancroft J, 2005, J ENDOCRINOL, V186, P411, DOI 10.1677/joe.1.06233
   Bansal TC, 2005, J SEX MED, V2, P96, DOI 10.1111/j.1743-6109.2005.20120.x
   Barnabei VM, 2002, OBSTET GYNECOL, V100, P1209, DOI 10.1016/S0029-7844(02)02369-4
   Basson R, 2003, J PSYCHOSOM OBST GYN, V24, P221, DOI 10.3109/01674820309074686
   Basson R.J., 2001, Journal Sex Reproduction Medicine, V1, P11, DOI DOI 10.4172/1488-5069.1000004
   Basson R, 2007, LANCET, V369, P409, DOI 10.1016/S0140-6736(07)60197-4
   BELISLE S, 2006, J OBSTET GYNAECOL CA, V172, P43
   Bell RJ, 2006, MENOPAUSE, V13, P65, DOI 10.1097/01.gme.0000191212.58856.96
   Bhasin S, 2005, J CLIN ENDOCR METAB, V90, P4970, DOI 10.1210/jc.2005-1328
   Bhasin S, 2006, J CLIN ENDOCR METAB, V91, P1995, DOI 10.1210/jc.2005-2847
   Billups KL, 2005, AM J CARDIOL, V96, p57M, DOI 10.1016/j.amjcard.2005.10.007
   Bivalacqua TJ, 2004, P NATL ACAD SCI USA, V101, P9121, DOI 10.1073/pnas.0400520101
   Boulton AJM, 2005, DIABETES CARE, V28, P956, DOI 10.2337/diacare.28.4.956
   Boulton AJM, 2001, DIABETOLOGIA, V44, P1296, DOI 10.1007/s001250100656
   Braga-Basaria M, 2006, J CLIN ONCOL, V24, P3979, DOI 10.1200/JCO.2006.05.9741
   Braunstein GD, 2005, ARCH INTERN MED, V165, P1582, DOI 10.1001/archinte.165.14.1582
   Buster JE, 2005, OBSTET GYNECOL, V105, P944, DOI 10.1097/01.AOG.0000158103.27672.0d
   Buvat J, 1997, J UROLOGY, V158, P1764, DOI 10.1016/S0022-5347(01)64123-5
   Carani C, 2005, J CLIN ENDOCR METAB, V90, P6472, DOI 10.1210/jc.2005-1135
   Carani C, 2005, PSYCHONEUROENDOCRINO, V30, P413, DOI 10.1016/j.psyneuen.2004.10.004
   CARANI C, 1990, ARCH SEX BEHAV, V19, P223, DOI 10.1007/BF01541548
   Cardozo L, 1998, OBSTET GYNECOL, V92, P722, DOI 10.1016/S0029-7844(98)00175-6
   Caruso S, 2006, FERTIL STERIL, V85, P1496, DOI 10.1016/j.fertnstert.2005.10.043
   Cavallini G, 2004, UROLOGY, V63, P641, DOI 10.1016/j.urology.2003.11.009
   CHOPRA IJ, 1974, J CLIN ENDOCR METAB, V38, P269, DOI 10.1210/jcem-38-2-269
   Colao A, 2003, EUR J ENDOCRINOL, V148, P325, DOI 10.1530/eje.0.1480325
   COLOA A, 2004, J CLIN ENDOCR METAB, V89, P1704
   Conaglen HA, 2003, J SEX MARITAL THER, V29, P255, DOI 10.1080/00926230390195498
   Corona G, 2004, EUR UROL, V46, P615, DOI 10.1016/j.eururo.2004.07.001
   Corona G, 2004, EUR UROL, V46, P222, DOI 10.1016/j.eururo.2004.03.010
   Corona G, 2006, EUR UROL, V50, P595, DOI 10.1016/j.eururo.2006.02.053
   Coviello AD, 2006, J CLIN ENDOCR METAB, V91, P492, DOI 10.1210/jc.2005-1666
   Davis SR, 2005, JAMA-J AM MED ASSOC, V294, P91, DOI 10.1001/jama.294.1.91
   DAVIS SR, 2006, MATURITAS S, V554, pS1
   Davis SR, 2006, MENOPAUSE, V13, P387, DOI 10.1097/01.gme.0000179049.08371.c7
   Davison SL, 2005, J CLIN ENDOCR METAB, V90, P3847, DOI 10.1210/jc.2005-0212
   Dayal M, 2005, J WOMENS HEALTH, V14, P391, DOI 10.1089/jwh.2005.14.391
   De Berardis G, 2005, DIABETES CARE, V28, P2637, DOI 10.2337/diacare.28.11.2637
   de Groot M, 2001, PSYCHOSOM MED, V63, P619, DOI 10.1097/00006842-200107000-00015
   De Rosa M, 2004, J CLIN ENDOCR METAB, V89, P621, DOI 10.1210/jc.2003-030852
   de Tejada IS, 2002, DIABETES CARE, V25, P2159
   de Tejada IS, 2005, J SEX MED, V2, P26, DOI 10.1111/j.1743-6109.2005.20103.x
   Delavierre D, 1999, PROG UROL, V9, P1097
   Dennerstein L, 2006, J SEX MED, V3, P212, DOI 10.1111/j.1743-6109.2006.00215.x
   Dennerstein L, 2005, FERTIL STERIL, V84, P174, DOI 10.1016/j.fertnstert.2005.01.119
   DEVRIESE AS, 2000, BRIT J PHARMACOL, V730, P963
   Dew JE, 2003, CLIMACTERIC, V6, P45, DOI 10.1080/713605341
   Dobs A S, 1998, Endocr Pract, V4, P355
   Donnelly P, 2000, CLIN ENDOCRINOL, V52, P197, DOI 10.1046/j.1365-2265.2000.00918.x
   Doruk H, 2005, ARCH ANDROLOGY, V51, P1, DOI 10.1080/014850190512798
   El-Sakka AI, 2005, J UROLOGY, V174, P1026, DOI 10.1097/01.ju.0000170231.51306.32
   Elsenbruch S, 2003, J CLIN ENDOCR METAB, V88, P5801, DOI 10.1210/jc.2003-030562
   Enzlin P, 2002, DIABETES CARE, V25, P672, DOI 10.2337/diacare.25.4.672
   Erol B, 2003, INT J IMPOT RES, V15, P198, DOI 10.1038/sj.ijir.3900998
   Erol B, 2002, J SEX MARITAL THER, V28, P55, DOI 10.1080/00926230252851195
   Esposito K, 2005, INT J IMPOT RES, V17, P391, DOI 10.1038/sj.ijir.3901333
   Esposito K, 2005, INT J IMPOT RES, V17, P224, DOI 10.1038/sj.ijir.3901310
   Esposito K, 2005, DIABETES CARE, V28, P756, DOI 10.2337/diacare.28.3.756
   Fedele D, 2000, INT J EPIDEMIOL, V29, P524, DOI 10.1093/ije/29.3.524
   FELDMAN HA, 1994, J UROLOGY, V151, P54, DOI 10.1016/S0022-5347(17)34871-1
   Ferrini RL, 1998, AM J EPIDEMIOL, V147, P750
   Finley SK, 1999, J NEUROBIOL, V40, P446
   Fonseca V, 2004, DIABETOLOGIA, V47, P1914, DOI 10.1007/s00125-004-1549-6
   Gazzaruso C, 2004, CIRCULATION, V110, P22, DOI 10.1161/01.CIR.0000133278.81226.C9
   Gerig NE, 1997, UROLOGY, V49, P239, DOI 10.1016/S0090-4295(96)00444-X
   Glueck CJ, 2003, METABOLISM, V52, P908, DOI 10.1016/S0026-0495(03)00104-5
   Golden SH, 2004, AM J EPIDEMIOL, V160, P540, DOI 10.1093/aje/kwh250
   Goldstein I, 2003, DIABETES CARE, V26, P777, DOI 10.2337/diacare.26.3.777
   Gontero P, 2005, INT J IMPOT RES, V17, P80, DOI 10.1038/sj.ijir.3901273
   GORZYNSKI G, 1977, ARCH SEX BEHAV, V6, P215, DOI 10.1007/BF01541129
   Hak AE, 2002, J CLIN ENDOCR METAB, V87, P3632, DOI 10.1210/jc.87.8.3632
   Harman SM, 2001, J CLIN ENDOCR METAB, V86, P724, DOI 10.1210/jc.86.2.724
   Hays J, 2003, NEW ENGL J MED, V348, P1839, DOI 10.1056/NEJMoa030311
   Hines M, 2004, J SEX RES, V41, P75, DOI 10.1080/00224490409552215
   Hirshkowitz M, 1997, J PSYCHOSOM RES, V42, P541, DOI 10.1016/S0022-3999(97)00006-8
   Hunt PJ, 2000, J CLIN ENDOCR METAB, V85, P4650, DOI 10.1210/jc.85.12.4650
   Israilov S, 2005, INT J IMPOT RES, V17, P431, DOI 10.1038/sj.ijir.3901337
   Johannsson G, 2002, J CLIN ENDOCR METAB, V87, P2046, DOI 10.1210/jc.87.5.2046
   Kadioglu P, 2005, J UROLOGY, V174, P1921, DOI 10.1097/01.ju.0000176456.50491.51
   Kalter-Leibovici O, 2005, DIABETES CARE, V28, P1739, DOI 10.2337/diacare.28.7.1739
   Kaufman JM, 2005, ENDOCR REV, V26, P833, DOI 10.1210/er.2004-0013
   Kenny AM, 2002, J GERONTOL A-BIOL, V57, pM321, DOI 10.1093/gerona/57.5.M321
   King BE, 1999, NEUROSCI LETT, V269, P149, DOI 10.1016/S0304-3940(99)00440-1
   Klein R, 2005, J DIABETES COMPLICAT, V19, P35, DOI 10.1016/j.jdiacomp.2003.12.005
   KOLODNY RC, 1971, DIABETES, V20, P557, DOI 10.2337/diab.20.8.557
   KORENMAN SG, 1990, J CLIN ENDOCR METAB, V71, P963, DOI 10.1210/jcem-71-4-963
   Korhonen S, 2003, FERTIL STERIL, V79, P1327, DOI 10.1016/S0015-0282(03)00347-9
   Krassas GE, 2003, J ENDOCRINOL INVEST, V26, P372, DOI 10.1007/BF03345187
   Krassas GE, 2002, J CLIN ENDOCR METAB, V87, P3667, DOI 10.1210/jc.87.8.3667
   Krassas GE, 2000, FERTIL STERIL, V74, P1063, DOI 10.1016/S0015-0282(00)01589-2
   Kulp JL, 2004, MENOPAUSE, V11, P116, DOI 10.1097/01.GME.0000079221.19081.11
   Kupelian V, 2006, J CLIN ENDOCR METAB, V91, P843, DOI 10.1210/jc.2005-1326
   Kushnir MM, 2006, CLIN CHEM, V52, P120, DOI 10.1373/clinchem.2005.052167
   KWAN M, 1983, J CLIN ENDOCR METAB, V57, P557, DOI 10.1210/jcem-57-3-557
   Laaksonen DE, 2005, J CLIN ENDOCR METAB, V90, P712, DOI 10.1210/jc.2004-0970
   Labrie F, 2003, ENDOCR REV, V24, P152, DOI 10.1210/er.2001-0031
   Labrie F, 2006, J STEROID BIOCHEM, V99, P182, DOI 10.1016/j.jsbmb.2006.02.004
   Laumann EO, 2005, INT J IMPOT RES, V17, P39, DOI 10.1038/sj.ijir.3901250
   Leiblum SR, 2006, MENOPAUSE, V13, P46, DOI 10.1097/01.gme.0000172596.76272.06
   Liverman CT., 2004, TESTOSTERONE AGING C
   Lovås K, 2003, J CLIN ENDOCR METAB, V88, P1112, DOI 10.1210/jc.2002-020769
   MACFARLANE I, 1997, TXB DIABETES, P1
   Meikle AW, 1997, J CLIN ENDOCR METAB, V82, P571, DOI 10.1210/jc.82.2.571
   Mills TM, 1999, STEROIDS, V64, P605, DOI 10.1016/S0039-128X(99)00040-9
   MORALI G, 1993, BIOL REPROD, V49, P577, DOI 10.1095/biolreprod49.3.577
   Motofei IG, 2005, INT J ANDROL, V28, P78, DOI 10.1111/j.1365-2605.2004.00514.x
   *N AM MEN SOC, 2003, MENOPAUSE, V10, P6
   Nwokolo NC, 2000, DRUG AGING, V16, P335, DOI 10.2165/00002512-200016050-00003
   Peng YS, 2005, KIDNEY INT, V68, P760, DOI 10.1111/j.1523-1755.2005.00454.x
   Platz EA, 1999, PROSTATE CANCER P D, V2, P285, DOI 10.1038/sj.pcan.4500380
   Pope HG, 2003, AM J PSYCHIAT, V160, P105, DOI 10.1176/appi.ajp.160.1.105
   RABKIN JG, 1995, GEN HOSP PSYCHIAT, V17, P37, DOI 10.1016/0163-8343(94)00062-I
   Reddy P, 2000, J CLIN PHARM THER, V25, P421, DOI 10.1046/j.1365-2710.2000.00309.x
   Redouté J, 2005, PSYCHONEUROENDOCRINO, V30, P461, DOI 10.1016/j.psyneuen.2004.12.003
   Rendell MS, 1999, JAMA-J AM MED ASSOC, V281, P421, DOI 10.1001/jama.281.5.421
   Rhoden EL, 2005, BJU INT, V95, P615, DOI 10.1111/j.1464-410X.2005.05349.x
   RYMER J, 1994, MATURITAS, V18, P127, DOI 10.1016/0378-5122(94)90050-7
   Sam S, 2005, J CLIN ENDOCR METAB, V90, P4797, DOI 10.1210/jc.2004-2217
   SANDS R, 1995, AM J MED, V98, pS76, DOI 10.1016/S0002-9343(99)80062-X
   Santoro N, 2005, J CLIN ENDOCR METAB, V90, P4836, DOI 10.1210/jc.2004-2063
   SCHIAVI RC, 1995, PSYCHIAT CLIN N AM, V18, P7, DOI 10.1016/S0193-953X(18)30067-4
   Schroeder JP, 2000, NEUROSCI LETT, V282, P17, DOI 10.1016/S0304-3940(00)00839-9
   Seftel AD, 1997, UROLOGY, V50, P1016, DOI 10.1016/S0090-4295(97)00512-8
   Seidman SN, 2005, J CLIN PSYCHOPHARM, V25, P584, DOI 10.1097/01.jcp.0000185424.23515.e5
   Seidman SN, 2001, J CLIN PSYCHIAT, V62, P406, DOI 10.4088/JCP.v62n0602
   Seidman SN, 2001, BIOL PSYCHIAT, V50, P371, DOI 10.1016/S0006-3223(01)01148-9
   Shifren JL, 2006, MENOPAUSE, V13, P770, DOI 10.1097/01.gme.0000227400.60816.52
   Simon J, 2005, J CLIN ENDOCR METAB, V90, P5226, DOI 10.1210/jc.2004-1747
   Singh AB, 2006, J CLIN ENDOCR METAB, V91, P136, DOI 10.1210/jc.2005-1640
   SLAG MF, 1983, JAMA-J AM MED ASSOC, V249, P1736, DOI 10.1001/jama.249.13.1736
   Snyder PJ, 1999, J CLIN ENDOCR METAB, V84, P2647, DOI 10.1210/jc.84.8.2647
   Snyder PJ, 2000, J CLIN ENDOCR METAB, V85, P2670, DOI 10.1210/jc.85.8.2670
   Sobel JD, 2003, AM J OBSTET GYNECOL, V189, P1297, DOI 10.1067/S0002-9378(03)00726-9
   Somboonporn W, 2005, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004509.pub2
   Steidle C, 2003, J CLIN ENDOCR METAB, V88, P2673, DOI 10.1210/jc.2002-021058
   Stenberg A, 1996, MATURITAS, V24, P31, DOI 10.1016/0378-5122(95)00996-5
   Stuckey BGA, 2003, DIABETES CARE, V26, P279, DOI 10.2337/diacare.26.2.279
   Traish AM, 2006, J SEX MED, V3, P382, DOI 10.1111/j.1743-6109.2006.00245.x
   Tuiten A, 2000, ARCH GEN PSYCHIAT, V57, P149, DOI 10.1001/archpsyc.57.2.149
   UTIAN WH, 1994, MENOPAUSE, V1, P39
   van Lunsen RHW, 2004, MENOPAUSE, V11, P741, DOI 10.1097/01.GME.0000143704.48324.46
   van Thiel SW, 2005, J CLIN ENDOCR METAB, V90, P3295, DOI 10.1210/jc.2004-1802
   Van Uytfanghe K, 2004, CLIN CHEM, V50, P2101, DOI 10.1373/clinchem.2004.037358
   Vermeulen A, 1999, J CLIN ENDOCR METAB, V84, P3666, DOI 10.1210/jc.84.10.3666
   Veronelli A, 2006, INT J IMPOT RES, V18, P111, DOI 10.1038/sj.ijir.3901364
   Wang C, 2000, J CLIN ENDOCR METAB, V85, P2839, DOI 10.1210/jc.85.8.2839
   Wang C, 2004, J CLIN ENDOCR METAB, V89, P534, DOI 10.1210/jc.2003-031287
   Weiner CL, 2004, PSYCHOSOM MED, V66, P356, DOI 10.1097/01.psy.0000127871.46309.fe
   Weisberg E, 2005, CLIMACTERIC, V8, P83, DOI 10.1080/13697130500087016
   Wierman ME, 2006, J CLIN ENDOCR METAB, V91, P3697, DOI 10.1210/jc.2006-1121
   Willhite LA, 2001, PHARMACOTHERAPY, V21, P464, DOI 10.1592/phco.21.5.464.34486
   WINCZE JP, 1993, ARCH SEX BEHAV, V22, P587, DOI 10.1007/BF01543302
   Wisniewski AB, 2004, J UROLOGY, V171, P2497, DOI 10.1097/01.ju.0000125269.91938.f7
   WORTSMAN J, 1987, AM J MED, V82, P207, DOI 10.1016/0002-9343(87)90057-X
   XIN Z, 2004, ZHONGGUO LINCHYUANG, V8, P4136
   Zheng H, 2006, DIABETES RES CLIN PR, V71, P313, DOI 10.1016/j.diabres.2005.07.011
   2002, FERTIL STERIL S4, V77, P1
NR 169
TC 208
Z9 215
U1 0
U2 23
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0140-6736
EI 1474-547X
J9 LANCET
JI Lancet
PD FEB 17
PY 2007
VL 369
IS 9561
BP 597
EP 611
DI 10.1016/S0140-6736(07)60280-3
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA 138MZ
UT WOS:000244368000034
PM 17307107
DA 2025-06-11
ER

PT J
AU Aljahdali, AA
   Shi, ZM
AF Aljahdali, Abeer Ali
   Shi, Zumin
TI Circadian Syndrome Is Associated with Dietary Patterns among
   Middle-Older Americans: The Health and Retirement Study
SO NUTRIENTS
LA English
DT Article
DE diet; dietary patterns; circadian rhythms; circadian syndrome; Health
   and Retirement Study; middle-older adults; US
ID ALL-CAUSE MORTALITY; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; RISK;
   RHYTHMS; METAANALYSIS; GLUCOSE; CLOCKS; COHORT; SYSTEM
AB Population aging is a global demographic characteristic of the 21st century, and healthy eating is a core component of healthy aging. However, limited evidence is available among older adults for associations between diet quality and circadian syndrome (CircS). Thus, this study examined associations between dietary patterns and CircS among a representative sample of middle-older adults in the US. The sample comprised middle-older adults enrolled in the 2016 core wave of the Health and Retirement Study (HRS) and one of its sub-studies, the 2013 Health Care and Nutrition Study (HCNS). A food frequency questionnaire was used to quantify habitual food intake and identify dietary patterns using a factor analysis. CircS was defined based on the existence of >= 4 components of metabolic syndrome and indicators of sleep disorders and depression. A total of 4253 middle-older adults with a mean age (SD) of 65.4 (10.0) years were included in the study. The prevalence of CircS was 35.9%. Comparing extreme quartiles of the "Prudent Pattern", the odds ratio (95% CI) for CircS was 0.72 (0.55-0.94), and it was 1.47 (1.10-1.95) for the "Western Pattern". The "Western Pattern" was positively associated while the "Prudent Pattern" was inversely associated with the odds of CircS among middle-older adults.
C1 [Aljahdali, Abeer Ali] King Abdulaziz Univ, Fac Appl Med Sci, Dept Clin Nutr, Jeddah 21589, Saudi Arabia.
   [Aljahdali, Abeer Ali] Univ Michigan, Dept Nutr Sci, Ann Arbor, MI 48109 USA.
   [Shi, Zumin] Qatar Univ, QU Hlth, Coll Hlth Sci, Human Nutr Dept, POB 2713, Doha, Qatar.
C3 King Abdulaziz University; University of Michigan System; University of
   Michigan; Qatar University
RP Shi, ZM (corresponding author), Qatar Univ, QU Hlth, Coll Hlth Sci, Human Nutr Dept, POB 2713, Doha, Qatar.
EM aaoaljahdali1@kau.edu.sa; zumin@qu.edu.qa
RI Shi, Zumin/A-1093-2009; Aljahdali, Abeer/AFP-2790-2022
OI Shi, Zumin/0000-0002-3099-3299; Aljahdali, Abeer/0000-0003-3104-1019
FU National Institute of Aging
FX No Statement Available
CR Agodi A, 2018, NUTRIENTS, V10, DOI 10.3390/nu10070898
   Akbar Z, 2023, NUTRIENTS, V15, DOI 10.3390/nu15153396
   Al-Khatib Y, 2022, CUREUS J MED SCIENCE, V14, DOI 10.7759/cureus.22153
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   [Anonymous], 2017, National Population Projections Tables. Table 1. Projected population size and births, deaths, and migration
   Atkins JL, 2016, BRIT J NUTR, V116, P1246, DOI 10.1017/S0007114516003147
   Bishop NJ, 2020, PUBLIC HEALTH NUTR, V23, P243, DOI 10.1017/S1368980019001496
   Bloom DE, 2016, HBK ECON, P3, DOI 10.1016/bs.hespa.2016.06.002
   Boege HL, 2021, CURR OPIN BIOTECH, V70, P1, DOI 10.1016/j.copbio.2020.08.009
   Cao YT, 2017, ASIA PAC J CLIN NUTR, V26, P1158, DOI 10.6133/apjcn.122016.03
   CDC's National Center for Chronic Disease Prevention and Health Promotion, 6 Tips for Healthy Aging
   Chen MX, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1131126
   Choi YJ, 2021, PUBLIC HEALTH NUTR, V24, P1638, DOI 10.1017/S1368980021000586
   Crnko S, 2019, NAT REV CARDIOL, V16, P437, DOI 10.1038/s41569-019-0167-4
   Fabiani R, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092056
   Ferraz-Bannitz R, 2021, BIOLOGY-BASEL, V10, DOI 10.3390/biology10030197
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Gheshlagh RG, 2016, IRAN RED CRESCENT ME, V18, DOI 10.5812/ircmj.26523
   Gramaglia C, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00621
   Grant PJ, 2008, DIABETES VASC DIS RE, V5, P75, DOI 10.3132/dvdr.2008.0012
   Hassannejad R, 2018, NUTR METAB CARDIOVAS, V28, P352, DOI 10.1016/j.numecd.2017.10.025
   Health and Retirement Study, 2018, Health Care and Nutrition Study (HCNS) 2013) public use dataset, Produced and distributed by the University of Michigan with funding from the National Institute on Aging (grant number NIA U01AG009740)
   Javeed N, 2018, PHYSIOLOGY, V33, P138, DOI 10.1152/physiol.00003.2018
   Jha PK, 2015, MOL CELL ENDOCRINOL, V418, P74, DOI 10.1016/j.mce.2015.01.024
   Lassale C, 2019, MOL PSYCHIATR, V24, P965, DOI 10.1038/s41380-018-0237-8
   Li Min-Dian, 2012, Yale Journal of Biology and Medicine, V85, P387
   LLabre JE, 2021, FASEB J, V35, DOI 10.1096/fj.202100610RR
   Long TX, 2022, JAMA NETW OPEN, V5, DOI 10.1001/jamanetworkopen.2022.1880
   López-Otín C, 2013, CELL, V153, P1194, DOI 10.1016/j.cell.2013.05.039
   Lotti S, 2023, NUTR METAB CARDIOVAS, V33, P1490, DOI 10.1016/j.numecd.2023.05.009
   Marques-Vidal P, 2018, BMC PUBLIC HEALTH, V18, DOI 10.1186/s12889-018-5045-1
   Medina L., Living Longer: Historical and Projected Life Expectancy in the United States, 1960 to 2060
   Orozco-Solis R, 2014, NEUROSCIENCE, V264, P76, DOI 10.1016/j.neuroscience.2014.01.043
   Panda S, 2019, NAT REV ENDOCRINOL, V15, P67, DOI 10.1038/s41574-018-0142-x
   Pickel L, 2020, FRONT NUTR, V7, DOI 10.3389/fnut.2020.00039
   Prasai MJ, 2008, DIABETES VASC DIS RE, V5, P89, DOI 10.3132/dvdr.2008.015
   Qian JY, 2016, TRENDS ENDOCRIN MET, V27, P282, DOI 10.1016/j.tem.2016.03.005
   Qiu WX, 2021, FRONT NEUROSCI-SWITZ, V15, DOI 10.3389/fnins.2021.728810
   Rabinovich-Nikitin I, 2019, CIRCULATION, V139, P965, DOI 10.1161/CIRCULATIONAHA.118.036550
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Rodríguez-Monforte M, 2017, EUR J NUTR, V56, P925, DOI 10.1007/s00394-016-1305-y
   Rüger M, 2009, REV ENDOCR METAB DIS, V10, P245, DOI 10.1007/s11154-009-9122-8
   Shab-Bidar S, 2018, PUBLIC HEALTH NUTR, V21, P1681, DOI [10.1017/S1368980018000216, 10.1017/s1368980018000216]
   Shi Z, 2021, J INTERN MED, V289, P851, DOI 10.1111/joim.13204
   Shi ZM, 2022, NUTRIENTS, V14, DOI 10.3390/nu14245317
   Shlisky J, 2017, ADV NUTR, V8, P17, DOI 10.3945/an.116.013474
   Smolensky MH, 2007, SLEEP MED, V8, P668, DOI 10.1016/j.sleep.2006.11.011
   Sonnega A, 2014, INT J EPIDEMIOL, V43, P576, DOI 10.1093/ije/dyu067
   Staels B, 2006, NAT MED, V12, P54, DOI 10.1038/nm0106-54
   Stenvers DJ, 2019, NAT REV ENDOCRINOL, V15, P75, DOI 10.1038/s41574-018-0122-1
   Stocks T, 2015, INT J EPIDEMIOL, V44, P1353, DOI 10.1093/ije/dyv001
   Thosar SS, 2018, J CLIN INVEST, V128, P2157, DOI 10.1172/JCI80590
   United States Census Bureau, 2020, census: 1 in 6 people in the United States were 65 and over
   Vaduganathan M, 2022, J AM COLL CARDIOL, V80, P2361, DOI 10.1016/j.jacc.2022.11.005
   Varraso R, 2012, AM J CLIN NUTR, V96, P1079, DOI 10.3945/ajcn.112.038109
   Vgontzas AN, 2005, SLEEP MED REV, V9, P211, DOI 10.1016/j.smrv.2005.01.006
   Wang YL, 2022, FRONT NEUROL, V13, DOI 10.3389/fneur.2022.946172
   WILLETT WC, 1985, AM J EPIDEMIOL, V122, P51, DOI 10.1093/oxfordjournals.aje.a114086
   Xiao YF, 2023, BMC PUBLIC HEALTH, V23, DOI 10.1186/s12889-023-15934-y
   Xiao YF, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1137668
   Xiong Y, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.715830
   Yu E, 2018, J AM COLL CARDIOL, V72, P914, DOI 10.1016/j.jacc.2018.02.085
   Yuguang L, 2024, FRONT ENDOCRINOL, V15, DOI 10.3389/fendo.2024.1293850
   Zhao H, 2022, NUTRIENTS, V14, DOI 10.3390/nu14061198
   Zimmet P, 2019, J INTERN MED, V286, P181, DOI 10.1111/joim.12924
   Zulyniak M.A., 2016, BMC Nutr, V2, DOI [10.1186/s40795-016-0074-6, DOI 10.1186/S40795-016-0074-6, DOI 10.1186/s40795-016-0074-6]
NR 68
TC 1
Z9 2
U1 5
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2024
VL 16
IS 6
AR 760
DI 10.3390/nu16060760
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MI0M4
UT WOS:001192876400001
PM 38542672
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Smolarczyk, K
   Meczekalski, B
   Rudnicka, E
   Suchta, K
   Szeliga, A
AF Smolarczyk, Katarzyna
   Meczekalski, Blazej
   Rudnicka, Ewa
   Suchta, Katarzyna
   Szeliga, Anna
TI Association of Obesity and Bariatric Surgery on Hair Health
SO MEDICINA-LITHUANIA
LA English
DT Review
DE obesity; hair loss; bariatric surgery
ID ONSET ANDROGENETIC ALOPECIA; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   RISK-FACTORS; WOMEN; MEN; ADIPOKINES; SOCIETY; LEPTIN
AB Obesity and obesity-related conditions today constitute a public health problem worldwide. Obesity is an "epidemic" chronic disorder, which is defined by the WHO as normal or excessive fat accumulation that may impair health. It is also defined for adults as a BMI that is greater than or equal to 30. The most common obesity-related diseases are type 2 diabetes mellitus, cardiovascular diseases, metabolic syndrome, chronic kidney disease, hyperlipidemia, hypertension, nonalcoholic fatty liver disease, and certain types of cancer. It has been also proven that obesity can have a negative effect on hair. It can lead to hair thinning. Patients with obesity can undergo bariatric surgery if they meet the inclusion criteria. The four common types of weight loss surgery include a duodenal switch with biliopancreatic diversion, laparoscopic adjustable gastric banding, Roux-en-Y gastric bypass, and sleeve gastrectomy. Bariatric surgery can affect skin and hair and is associated with telogen effluvium due to weight loss, microelement deficiency, anesthesia, low calorie intake, and low protein intake. Patients who undergo bariatric surgery can experience post-bariatric surgery depression. Hair loss can have a major impact on self-esteem, negatively affecting one's self-image. The purpose of this narrative review is to critically review how obesity, obesity-related diseases, and bariatric surgery affect hair health in general and the hair development cycle, and how they influence hair loss.
C1 [Smolarczyk, Katarzyna] Med Univ Warsaw, Dept Dermatol, PL-02008 Warsaw, Poland.
   [Meczekalski, Blazej; Szeliga, Anna] Poznan Univ Med Sci, Dept Gynecol Endocrinol, PL-60535 Poznan, Poland.
   [Rudnicka, Ewa; Suchta, Katarzyna] Warsaw Med Univ, Dept Gynecol Endocrinol, PL-00315 Warsaw, Poland.
C3 Medical University of Warsaw; Poznan University of Medical Sciences;
   Medical University of Warsaw
RP Smolarczyk, K (corresponding author), Med Univ Warsaw, Dept Dermatol, PL-02008 Warsaw, Poland.
EM ksmolarczyk@gmail.com; blazejmeczekalski@yahoo.com;
   ewa.rudnicka@poczta.onet.pl; suchta.katarzyna@gmail.com;
   annamaria.szeliga@gmail.com
RI Suchta, Katarzyna/KBA-7024-2024; Rudnicka, Ewa/U-4988-2018
OI Suchta, Katarzyna/0000-0003-1715-1262; Rudnicka, Ewa/0000-0002-3936-5598
CR Acibucu F, 2010, SINGAP MED J, V51, P931
   Aljefree NM, 2022, HEALTHCARE-BASEL, V10, DOI 10.3390/healthcare10020400
   Almohanna HM, 2019, DERMATOLOGY THER, V9, P51, DOI 10.1007/s13555-018-0278-6
   Arias-Santiago S, 2010, BRIT J DERMATOL, V162, P786, DOI 10.1111/j.1365-2133.2009.09588.x
   Asghar F, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.8320
   Avila C, 2015, CURR OBES REP, V4, P303, DOI 10.1007/s13679-015-0164-9
   Bennour I, 2022, NUTRIENTS, V14, DOI 10.3390/nu14102049
   Brzezinska-Wcislo L, 2018, PRZ DERMATOL, V105, P1, DOI 10.5114/dr.2018.74162
   Chakrabarty S, 2014, Int J Trichology, V6, P50, DOI 10.4103/0974-7753.138586
   Chen Q, 2017, VISION RES, V139, P47, DOI 10.1016/j.visres.2017.02.007
   Cohen-Kurzrock RA, 2021, CUREUS J MED SCIENCE, V13, DOI 10.7759/cureus.14617
   Darlenski R, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.855573
   Dharam Kumar K C, 2018, Indian J Endocrinol Metab, V22, P196, DOI 10.4103/ijem.IJEM_650_17
   Dhurat Rachita, 2009, Int J Trichology, V1, P108, DOI 10.4103/0974-7753.58553
   Dopytalska K, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-01391-8
   Eisenberg D, 2022, SURG OBES RELAT DIS, V18, P1345, DOI 10.1016/j.soard.2022.08.013
   El Sayed MH, 2016, INT J DERMATOL, V55, P1131, DOI 10.1111/ijd.13303
   Fang PH, 2023, AGEING RES REV, V84, DOI 10.1016/j.arr.2022.101829
   Friedlich A.L., 1955, Angiology, V6, P165
   Fujimaki S, 2001, J INT MED RES, V29, P108, DOI 10.1177/147323000102900207
   Gasmi A, 2022, EUR J NUTR, V61, P55, DOI 10.1007/s00394-021-02619-8
   Ghantous CM, 2015, INT J ENDOCRINOL, V2015, DOI 10.1155/2015/534320
   Guo HaiJun Guo HaiJun, 2017, Chinese Journal of Digestive Surgery, V16, P592
   Hu J J, 2017, Zhonghua Yu Fang Yi Xue Za Zhi, V51, P1065, DOI 10.3760/cma.j.issn.0253-9624.2017.12.003
   Katsogridaki G, 2018, OBES SURG, V28, P3929, DOI 10.1007/s11695-018-3433-3
   Kim MW, 2017, J EUR ACAD DERMATOL, V31, P942, DOI 10.1111/jdv.14000
   Kyei A, 2011, ARCH DERMATOL, V147, P909, DOI 10.1001/archdermatol.2011.66
   Ledoux S, 2020, OBES SURG, V30, P1891, DOI 10.1007/s11695-020-04412-8
   Lee SW, 2012, J OBSTET GYNAECOL, V32, P73, DOI 10.3109/01443615.2011.618893
   Lonnie M, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph192013647
   Ludwig DS, 2018, JAMA INTERN MED, V178, P1098, DOI 10.1001/jamainternmed.2018.2933
   McDonald KA, 2017, J AM ACAD DERMATOL, V76, P472, DOI 10.1016/j.jaad.2016.10.002
   Mechanick JI, 2019, ENDOCR PRACT, V25, P1346, DOI [10.4158/GL-2019-0406, 10.1002/oby.22719]
   Minokawa Y, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23031038
   Morinaga H, 2021, NATURE, V595, P266, DOI 10.1038/s41586-021-03624-x
   Nakamura K, 2014, J CARDIOL, V63, P250, DOI 10.1016/j.jjcc.2013.11.006
   Olszewska M, 2010, ENDOKRYNOL POL, V61, P406
   Papafotiou C, 2017, STRESS, V20, P217, DOI 10.1080/10253890.2017.1303830
   Pengsalae Nopparat, 2013, Journal of the Medical Association of Thailand, V96, P947
   Pereira LJ, 2023, BRIT J NUTR, V129, P1626, DOI 10.1017/S0007114522000228
   Pereira-Santos M, 2015, OBES REV, V16, P341, DOI 10.1111/obr.12239
   Qi WW, 2015, DIABETES, V64, P1407, DOI 10.2337/db14-1111
   Rojas P, 2011, NUTR HOSP, V26, P856, DOI [10.1590/S0212-16112011000400028, 10.3305/nh.2011.26.4.5199]
   Ruiz-Tovar J, 2014, AM SURGEON, V80, P466
   Ryan DH, 2023, GASTROENTEROL CLIN N, V52, P645, DOI 10.1016/j.gtc.2023.08.001
   Sadighha A, 2009, J EUR ACAD DERMATOL, V23, P80, DOI 10.1111/j.1468-3083.2008.02704.x
   Safaei M, 2021, COMPUT BIOL MED, V136, DOI 10.1016/j.compbiomed.2021.104754
   Schulze PC, 2011, J CARD FAIL, V17, P1004, DOI 10.1016/j.cardfail.2011.08.010
   Sen O, 2021, J LAPAROENDOSC ADV S, V31, P296, DOI 10.1089/lap.2020.0468
   Serarslan G, 2021, IRISH J MED SCI, V190, P1015, DOI 10.1007/s11845-020-02410-4
   Sharma Lata, 2013, Indian Dermatol Online J, V4, P283, DOI 10.4103/2229-5178.120638
   Shin H, 2015, J AM ACAD DERMATOL, V72, P321, DOI 10.1016/j.jaad.2014.11.008
   Stierman Bryan, 2021, Natl Health Stat Report, DOI 10.15620/cdc:106273
   Stochmal A, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-92853-1
   Su LH, 2010, BRIT J DERMATOL, V163, P371, DOI 10.1111/j.1365-2133.2010.09816.x
   Swaroop MR, 2019, INDIAN J DERMATOL, V64, P23, DOI 10.4103/ijd.IJD_724_16
   Trieu N, 2014, INT J CARDIOL, V176, P687, DOI 10.1016/j.ijcard.2014.07.079
   Verduci E, 2021, J PEDIATR GASTR NUTR, V72, P769, DOI 10.1097/MPG.0000000000003075
   Vranic L, 2019, MEDICINA-LITHUANIA, V55, DOI 10.3390/medicina55090541
   Wang CC, 2014, SURG LAPARO ENDO PER, V24, pE216, DOI 10.1097/SLE.0000000000000004
   Wang MH, 2022, J DIABETES RES, V2022, DOI 10.1155/2022/8938276
   World Health Organization, 2021, Obesity and overweight, fact sheet
   Yang CC, 2017, EXP DERMATOL, V26, P524, DOI 10.1111/exd.13369
   Yang CC, 2014, J AM ACAD DERMATOL, V70, P297, DOI 10.1016/j.jaad.2013.09.036
   Yang M, 2022, HEALTHCARE-BASEL, V10, DOI 10.3390/healthcare10091616
   Yun JE, 2010, METABOLISM, V59, P424, DOI 10.1016/j.metabol.2009.08.012
   Zhang W, 2021, OBES SURG, V31, P2649, DOI 10.1007/s11695-021-05311-2
NR 67
TC 5
Z9 5
U1 2
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD FEB
PY 2024
VL 60
IS 2
AR 325
DI 10.3390/medicina60020325
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA JI8C5
UT WOS:001172617800001
PM 38399612
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ahuja, S
   Caldwell, JD
   Shanks, BC
   Flores, R
AF Ahuja, Suman
   Caldwell, James D.
   Shanks, Bruce C.
   Flores, Rene
TI Effects of macronutrient composition and meal frequency on cortisol
   levels in humans
SO AGRO FOOD INDUSTRY HI-TECH
LA English
DT Article
ID PSYCHOSOCIAL STRESS; HEALTHY-SUBJECTS; PLASMA-CORTISOL; PROTEIN; FAT;
   SECRETION; DIET; BEHAVIOR; OBESITY; WEIGHT
AB Obesity has reached epidemic proportions world-wide with approximately 1.6 billion adults overweight (Body Mass Index (BMI) >= 25kg/m(2)), almost 400 million clinically obese (BMI >= 30kg/m(2)), and an estimated 2.3 billion people will be overweight by the year 2015 (1). Obesity is a major risk factor for several chronic diseases and is a multi-factorial disorder that includes many contributing factors such as quality and quantity of food consumption, physical activity, hormonal imbalance, and life style choices. Of these, new attention has been given to certain hormones elevated by macronutrients and their relationship with other disorders. There has been speculation that moderate increase in cortisol levels may lead to an increased risk for cardiovascular disease, glucose intolerance, hypertension, and dyslipidemia, all classic conditions associated with metabolic syndrome (2). In fact, it has been reported that exposure to elevated maternal cortisol levels may have a negative impact on the fetus, which may result in predisposition to high blood pressure, elevated basal stress-induced glucocorticoid, and other features of metabolic syndrome in later adult life (3). Of the many contributing factors of obesity, it appears that macronutrient composition and frequency of meal consumption might be two important pieces of this puzzle. Both, meal composition and frequency have shown to impact various hormones, particularly those related to obesity, diabetes, and CVD. Therefore, we propose to review effects of macronutrient composition and meal frequency on cortisol levels in humans.
C1 [Flores, Rene] Univ Texas Hlth Sci Ctr Houston, Ctr Nursing Res, Houston, TX 77030 USA.
   [Ahuja, Suman; Caldwell, James D.; Shanks, Bruce C.] Lincoln Univ, Dept Agr & Environm Sci, Jefferson City, MO 65101 USA.
C3 University of Texas System; University of Texas Health Science Center
   Houston; Lincoln University - Missouri
RP Flores, R (corresponding author), Univ Texas Hlth Sci Ctr Houston, Ctr Nursing Res, 6901 Bertner Ave, Houston, TX 77030 USA.
RI Martínez Flores, René/GLT-6329-2022
CR ANDERSON KE, 1987, LIFE SCI, V40, P1761, DOI 10.1016/0024-3205(87)90086-5
   Bogdan A, 2001, LIFE SCI, V68, P1607, DOI 10.1016/S0024-3205(01)00966-3
   Brydon L, 2011, BIOL PSYCHOL, V86, P114, DOI 10.1016/j.biopsycho.2010.02.010
   Dallman MF, 2004, ENDOCRINOLOGY, V145, P2633, DOI 10.1210/en.2004-0037
   Epel ES, 2000, PSYCHOSOM MED, V62, P623, DOI 10.1097/00006842-200009000-00005
   Gibson EL, 1999, PSYCHOSOM MED, V61, P214, DOI 10.1097/00006842-199903000-00014
   Gonzalez-Bono E, 2002, HORM BEHAV, V41, P328, DOI 10.1006/hbeh.2002.1766
   Herrick K, 2003, J CLIN ENDOCR METAB, V88, P3554, DOI 10.1210/jc.2003-030287
   Holt JP, 2006, J ANIM SCI, V84, P946, DOI 10.2527/2006.844946x
   Iranmanesh A, 2011, J CLIN ENDOCR METAB, V96, P2882, DOI 10.1210/jc.2011-0682
   ISHIZUKA B, 1983, J CLIN ENDOCR METAB, V57, P1111, DOI 10.1210/jcem-57-6-1111
   Lemmens SG, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016826
   MARIN P, 1992, METABOLISM, V41, P882, DOI 10.1016/0026-0495(92)90171-6
   Marniemi J, 2002, J INTERN MED, V251, P35, DOI 10.1046/j.1365-2796.2002.00921.x
   McGlone JJ, 2001, J ANIM SCI, V79, P1466
   Posener JA, 1996, PSYCHONEUROENDOCRINO, V21, P33, DOI 10.1016/0306-4530(95)00033-X
   Posener JA, 1998, PSYCHONEUROENDOCRINO, V23, P371, DOI 10.1016/S0306-4530(98)00006-7
   Reynolds RM, 2010, J CLIN ENDOCR METAB, V95, P1602, DOI 10.1210/jc.2009-2112
   Schwarz NA, 2011, J NUTR METAB, V2011, DOI 10.1155/2011/237932
   SLAG MF, 1981, METABOLISM, V30, P1104, DOI 10.1016/0026-0495(81)90055-X
   Stimson RH, 2007, J CLIN ENDOCR METAB, V92, P4480, DOI 10.1210/jc.2007-0692
   Stote KS, 2007, AM J CLIN NUTR, V85, P981, DOI 10.1093/ajcn/85.4.981
NR 22
TC 0
Z9 0
U1 0
U2 6
PU TEKNOSCIENZE PUBL
PI MILANO
PA VIALE BRIANZA 22, 20127 MILANO, ITALY
SN 1722-6996
J9 AGRO FOOD IND HI TEC
JI Agro Food Ind. Hi-Tech
PD MAR-APR
PY 2012
VL 23
IS 2
SU S
BP 4
EP 5
PG 2
WC Biotechnology & Applied Microbiology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Food Science & Technology
GA 953CS
UT WOS:000304845100002
DA 2025-06-11
ER

PT J
AU Soda, T
   Pasqua, T
   De Sarro, G
   Moccia, F
AF Soda, Teresa
   Pasqua, Teresa
   De Sarro, Giovambattista
   Moccia, Francesco
TI Cognitive Impairment and Synaptic Dysfunction in Cardiovascular
   Disorders: The New Frontiers of the Heart-Brain Axis
SO BIOMEDICINES
LA English
DT Review
DE heart-brain axis; cardiovascular disorders; synaptic plasticity;
   cardiogenic dementia; cognitive impairment; heart failure; metabolic
   syndrome; arrhythmias; NMDA receptors; long-term potentiation
ID LONG-TERM POTENTIATION; METABOTROPIC GLUTAMATE RECEPTORS;
   STREPTOZOTOCIN-DIABETIC RATS; TIMING-DEPENDENT PLASTICITY;
   ANGIOTENSIN-II; AMPA RECEPTORS; ANIMAL-MODEL; INTRACEREBROVENTRICULAR
   INJECTION; HIPPOCAMPAL GLUTAMATE; INSULIN-RESISTANCE
AB Within the central nervous system, synaptic plasticity, fundamental to processes like learning and memory, is largely driven by activity-dependent changes in synaptic strength. This plasticity often manifests as long-term potentiation (LTP) and long-term depression (LTD), which are bidirectional modulations of synaptic efficacy. Strong epidemiological and experimental evidence show that the heart-brain axis could be severely compromised by both neurological and cardiovascular disorders. Particularly, cardiovascular disorders, such as heart failure, hypertension, obesity, diabetes and insulin resistance, and arrhythmias, may lead to cognitive impairment, a condition known as cardiogenic dementia. Herein, we review the available knowledge on the synaptic and molecular mechanisms by which cardiogenic dementia may arise and describe how LTP and/or LTD induction and maintenance may be compromised in the CA1 region of the hippocampus by heart failure, metabolic syndrome, and arrhythmias. We also discuss the emerging evidence that endothelial dysfunction may contribute to directly altering hippocampal LTP by impairing the synaptically induced activation of the endothelial nitric oxide synthase. A better understanding of how CV disorders impact on the proper function of central synapses will shed novel light on the molecular underpinnings of cardiogenic dementia, thereby providing a new perspective for more specific pharmacological treatments.
C1 [Soda, Teresa; Pasqua, Teresa; De Sarro, Giovambattista] Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy.
   [Moccia, Francesco] Univ Molise, Dept Med & Hlth Sci V Tiberio, I-86100 Campobasso, Italy.
C3 Magna Graecia University of Catanzaro; University of Molise
RP Soda, T (corresponding author), Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy.
EM teresa.soda@unicz.it; teresa.pasqua@unicz.it; desarro@unicz.it;
   francesco.moccia@unimol.it
RI De Sarro, Giovambattista/G-5256-2010; Moccia, Francesco/AAX-6447-2020;
   Soda, Teresa/HNS-4686-2023
OI Moccia, Francesco/0000-0003-0010-0098; Soda, Teresa/0000-0002-7728-6815;
   De Sarro, Giovambattista/0000-0002-7629-6579
FU #NEXTGENERATIONEU (NGEU); Ministry of University and Research (MUR)
   [PE0000006, 1553 11.10.2022]; National Recovery and Resilience Plan
   (NRRP); European Commission's FESR FSE
FX This research has been supported by #NEXTGENERATIONEU (NGEU) and funded
   by the Ministry of University and Research (MUR), National Recovery and
   Resilience Plan (NRRP), project MNESYS (PE0000006)-A Multiscale
   integrated approach to the study of the nervous system in health and
   disease (DN. 1553 11.10.2022) (G.D.S. and F.M.) and European
   Commission's FESR FSE 2014-2020 and POR CALABRIA FESR AZIONE 1.5.1
   "Support for research infrastructures considered critical/crucial for
   regional systems" Nuova Piattaforma di Farmacologia Integrata e
   Tecnologie Avanzate (G.D.S.).
CR Abbas T, 2009, BEHAV BRAIN RES, V205, P265, DOI 10.1016/j.bbr.2009.06.035
   Abbott KN, 2019, NEUROSCI BIOBEHAV R, V107, P399, DOI 10.1016/j.neubiorev.2019.08.010
   Alaaeddine R, 2019, J PHARMACOL EXP THER, V371, P567, DOI 10.1124/jpet.119.262048
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Aleman A, 2009, PROG NEUROBIOL, V89, P256, DOI 10.1016/j.pneurobio.2009.07.008
   Allen P, 2019, NEUROSCI BIOBEHAV R, V99, P90, DOI 10.1016/j.neubiorev.2019.02.004
   Althammer F, 2023, HYPERTENSION, V80, P1258, DOI 10.1161/HYPERTENSIONAHA.123.21070
   Alzoubi KH, 2005, J MOL NEUROSCI, V27, P337, DOI 10.1385/JMN:27:3:337
   Andrade-Talavera Y, 2023, MOL PSYCHIATR, V28, P2177, DOI 10.1038/s41380-023-02027-w
   [Anonymous], 1977, LANCET, V1, P27
   Ansari MA, 2023, CELLS-BASEL, V12, DOI 10.3390/cells12131728
   Ansari MA, 2023, BRAIN RES, V1798, DOI 10.1016/j.brainres.2022.148134
   Appelbaum LG, 2023, NEUROPSYCHOPHARMACOL, V48, P113, DOI 10.1038/s41386-022-01370-w
   Armando I, 2003, CNS NEUROL DISORD-DR, V2, P413, DOI 10.2174/1568007033482661
   Artola A, 2005, EUR J NEUROSCI, V22, P169, DOI 10.1111/j.1460-9568.2005.04205.x
   Badaly D, 2022, FRONT NEUROL, V13, DOI 10.3389/fneur.2022.827780
   Baggeroer CE, 2024, HYPERTENSION, V81, P34, DOI 10.1161/HYPERTENSIONAHA.123.19939
   Barber TM, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22020546
   Beilharz JE, 2015, NUTRIENTS, V7, P6719, DOI 10.3390/nu7085307
   Bermudez C, 2024, MAGN RESON IMAGING, V109, P49, DOI 10.1016/j.mri.2024.02.016
   Berra-Romani R, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21010250
   Bhat S, 2012, PROG NEUROBIOL, V99, P1, DOI 10.1016/j.pneurobio.2012.06.001
   Biessels GJ, 1998, BRAIN RES, V800, P125, DOI 10.1016/S0006-8993(98)00510-1
   Biessels GJ, 1996, DIABETES, V45, P1259, DOI 10.2337/diabetes.45.9.1259
   Bliss TVP, 2013, MOL BRAIN, V6, DOI 10.1186/1756-6606-6-5
   Boitard C, 2015, J NEUROSCI, V35, P4092, DOI 10.1523/JNEUROSCI.3122-14.2015
   Bozkurt B, 2021, EUR J HEART FAIL, V23, P352, DOI 10.1002/ejhf.2115
   Bridi M, 2020, JCI INSIGHT, V5, DOI 10.1172/jci.insight.92385
   Brunetti V, 2024, BIOMEDICINES, V12, DOI 10.3390/biomedicines12040880
   Chabot C, 1997, BRAIN RES, V768, P249, DOI 10.1016/S0006-8993(97)00648-3
   Chellammal HSJ, 2022, J DIABETES METAB DIS, V21, P1415, DOI 10.1007/s40200-022-01074-4
   Chen Jie, 2024, Aging-US, V16, P10882, DOI 10.18632/aging.205960
   Chen XS, 2024, CARDIOLOGY, V149, P369, DOI 10.1159/000538409
   Chen ZL, 2017, CIRC RES, V121, P451, DOI 10.1161/CIRCRESAHA.117.311170
   Cheng M, 2018, NEUROCHEM RES, V43, P1047, DOI 10.1007/s11064-018-2515-x
   Correa Sonia A L, 2012, J Signal Transduct, V2012, P649079, DOI 10.1155/2012/649079
   Torres DMC, 2020, REV NEUROSCIENCE, V31, P245, DOI 10.1515/revneuro-2019-0058
   Cui C, 2024, CELL MOL NEUROBIOL, V44, DOI 10.1007/s10571-024-01491-4
   Cui Y, 2022, J MAGN RESON IMAGING, V56, P1621, DOI 10.1002/jmri.28358
   D'Angelo E, 2014, PROG BRAIN RES, V210, P31, DOI 10.1016/B978-0-444-63356-9.00002-9
   Dai HL, 2016, SCI REP-UK, V6, DOI 10.1038/srep27600
   Davari S, 2013, NEUROSCIENCE, V240, P287, DOI 10.1016/j.neuroscience.2013.02.055
   David H, 2021, FRONT CARDIOVASC MED, V7, DOI 10.3389/fcvm.2020.615507
   Di Luca M, 1999, DIABETOLOGIA, V42, P693, DOI 10.1007/s001250051217
   Díaz HS, 2020, J PHYSIOL-LONDON, V598, P33, DOI 10.1113/JP278864
   Doehner W, 2023, QJM-INT J MED, V116, P897, DOI 10.1093/qjmed/hcad179
   Doreulee N, 2003, BRAIN RES, V964, P159, DOI 10.1016/S0006-8993(02)04121-5
   Eckernäs D, 2019, IBRO REP, V6, DOI 10.1016/j.ibror.2018.11.007
   Eisner DA, 2017, CIRC RES, V121, P181, DOI 10.1161/CIRCRESAHA.117.310230
   Engin A, 2017, ADV EXP MED BIOL, V960, P1, DOI 10.1007/978-3-319-48382-5_1
   Engl E, 2015, J PHYSIOL-LONDON, V593, P3417, DOI 10.1113/jphysiol.2014.282517
   Ezra-Nevo G, 2018, J NEUROSCI, V38, P6751, DOI 10.1523/JNEUROSCI.3106-15.2018
   Fang SP, 2024, BIOMEDICINES, V12, DOI 10.3390/biomedicines12081719
   Favieri F, 2019, FRONT PSYCHOL, V10, DOI 10.3389/fpsyg.2019.02126
   Fekete M, 2024, GEROSCIENCE, DOI 10.1007/s11357-024-01290-1
   Feldman DE, 2012, NEURON, V75, P556, DOI 10.1016/j.neuron.2012.08.001
   Foster WJ, 2018, SCI SIGNAL, V11, DOI 10.1126/scisignal.aat9093
   Franzon R, 2005, DIABETES RES CLIN PR, V69, P107, DOI 10.1016/j.diabres.2004.11.010
   Freeman K, 2023, bioRxiv, DOI [10.1101/2023.08.08.552492, 10.1101/2023.08.08.552492, DOI 10.1101/2023.08.08.552492]
   Gao M, 2019, NEUROL RES, V41, P1024, DOI 10.1080/01616412.2019.1672387
   Gardoni F, 2002, J NEUROCHEM, V80, P438, DOI 10.1046/j.0022-3042.2001.00713.x
   Garthwaite G, 2006, J NEUROSCI, V26, P7730, DOI 10.1523/JNEUROSCI.1528-06.2006
   GEAN PW, 1993, NEUROSCI LETT, V158, P170, DOI 10.1016/0304-3940(93)90256-K
   Gerges NZ, 2003, NEUROSCIENCE, V120, P535, DOI 10.1016/S0306-4522(03)00297-5
   Ghaderi S, 2024, PHYTOTHER RES, V38, P1262, DOI 10.1002/ptr.8111
   Gómez-Apo E, 2021, J OBES, V2021, DOI 10.1155/2021/6613385
   Grant WB, 2024, J ALZHEIMERS DIS, V100, pS165, DOI 10.3233/JAD-240658
   Greer PL, 2008, NEURON, V59, P846, DOI 10.1016/j.neuron.2008.09.002
   Grosshans DR, 2002, NAT NEUROSCI, V5, P27, DOI 10.1038/nn779
   Guerra G, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19040938
   Guo W, 2018, DEV NEUROBIOL, V78, P647, DOI 10.1002/dneu.22592
   Hagena H, 2024, PHILOS T R SOC B, V379, DOI 10.1098/rstb.2023.0229
   Hakim MA, 2023, MICROCIRCULATION, V30, DOI 10.1111/micc.12797
   Hakim MA, 2021, J ALZHEIMERS DIS REP, V5, P693, DOI 10.3233/ADR-210016
   Hansen KB, 2018, J GEN PHYSIOL, V150, P1081, DOI 10.1085/jgp.201812032
   Hanson P, 2020, THER ADV ENDOCRINOL, V11, DOI 10.1177/2042018820922018
   Harnett MT, 2009, NEURON, V62, P826, DOI 10.1016/j.neuron.2009.05.011
   Harney SC, 2008, J NEUROSCI, V28, P11685, DOI 10.1523/JNEUROSCI.3035-08.2008
   Harney SC, 2006, J NEUROSCI, V26, P1128, DOI 10.1523/JNEUROSCI.2753-05.2006
   Hennigan A, 2009, BEHAV BRAIN RES, V197, P371, DOI 10.1016/j.bbr.2008.09.037
   Hernández-Ramírez S, 2021, PSYCHONEUROENDOCRINO, V127, DOI 10.1016/j.psyneuen.2021.105178
   Hofmeijer J, 2014, BRAIN RES, V1557, P180, DOI 10.1016/j.brainres.2014.02.027
   Hofmeijer J, 2012, STROKE, V43, P607, DOI 10.1161/STROKEAHA.111.632943
   Hopper RA, 2006, J NEUROSCI, V26, P11513, DOI 10.1523/JNEUROSCI.2259-06.2006
   Horigane S, 2020, FEBS OPEN BIO, V10, P1436, DOI 10.1002/2211-5463.12924
   Hristov M, 2024, METAB BRAIN DIS, V39, P321, DOI 10.1007/s11011-023-01299-z
   Iadecola C, 2013, NEURON, V80, P844, DOI 10.1016/j.neuron.2013.10.008
   Ichijo Y, 2020, J AM HEART ASSOC, V9, DOI 10.1161/JAHA.119.014564
   Ishrat T, 2006, BEHAV BRAIN RES, V171, P9, DOI 10.1016/j.bbr.2006.03.009
   Ishrat T, 2009, BEHAV PHARMACOL, V20, P567, DOI 10.1097/FBP.0b013e32832c7125
   Ismail TR, 2023, BIOLOGY-BASEL, V12, DOI 10.3390/biology12030480
   Iwai T, 2009, NEUROSCI RES, V64, P67, DOI 10.1016/j.neures.2009.01.013
   Jauch-Chara K, 2014, PROG NEUROBIOL, V114, P84, DOI 10.1016/j.pneurobio.2013.12.001
   Jensen V, 2009, NEUROSCIENCE, V158, P353, DOI 10.1016/j.neuroscience.2008.05.016
   Johnstone A, 2020, CELL TISSUE RES, V382, P101, DOI 10.1007/s00441-020-03278-7
   Kalalian-Moghaddam H, 2013, EUR J PHARMACOL, V698, P259, DOI 10.1016/j.ejphar.2012.10.020
   Kamal A, 2006, BRAIN RES, V1073, P276, DOI 10.1016/j.brainres.2005.12.070
   Kamal A, 2003, NEUROSCIENCE, V118, P577, DOI 10.1016/S0306-4522(02)00874-6
   Kamal A, 1999, NEUROSCIENCE, V90, P737, DOI 10.1016/S0306-4522(98)00485-0
   Kamijo S, 2018, J NEUROSCI, V38, P5551, DOI 10.1523/JNEUROSCI.2357-17.2018
   Karimi SA, 2015, NEUROCHEM RES, V40, P811, DOI 10.1007/s11064-015-1531-3
   Keefe JA, 2023, MAMM GENOME, V34, P298, DOI 10.1007/s00335-022-09964-x
   Kelley RE, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9121835
   Kelly A, 1998, NEUROPHARMACOLOGY, V37, P561, DOI 10.1016/S0028-3908(98)00048-3
   Kelly A, 2000, HIPPOCAMPUS, V10, P431, DOI 10.1002/1098-1063(2000)10:4<431::AID-HIPO9>3.0.CO;2-Z
   Kendig MD, 2014, APPETITE, V80, P41, DOI 10.1016/j.appet.2014.04.028
   Kerchner GA, 2008, NAT REV NEUROSCI, V9, P813, DOI 10.1038/nrn2501
   Khaledi N, 2024, NEUROL RES, V46, P835, DOI 10.1080/01616412.2024.2359265
   Kharroubi AT, 2015, WORLD J DIABETES, V6, P850, DOI 10.4239/wjd.v6.i6.850
   Kitzbichler MG, 2023, ELIFE, V12, DOI 10.7554/eLife.85175
   Kogelschatz B, 2024, TRENDS CARDIOVAS MED, V34, P236, DOI 10.1016/j.tcm.2023.01.005
   Kouvari M, 2022, NUTRIENTS, V14, DOI 10.3390/nu14020333
   Krishnan B, 2020, J NEUROCHEM, V153, P51, DOI 10.1111/jnc.14915
   Ku PH, 2024, FRONT AGING NEUROSCI, V16, DOI 10.3389/fnagi.2024.1392304
   Kwon HB, 2008, NEURON, V60, P1082, DOI 10.1016/j.neuron.2008.10.045
   Lacalle-Aurioles M, 2022, BRIT J PHARMACOL, V179, P2259, DOI 10.1111/bph.15751
   le Feber J, 2017, J NEUROPHYSIOL, V118, P394, DOI 10.1152/jn.00098.2017
   Le Thuc O, 2024, NAT METAB, V6, P1237, DOI 10.1038/s42255-024-01079-8
   Lee CC, 2021, J CELL MOL MED, V25, P8546, DOI 10.1111/jcmm.16816
   LeMaistre JL, 2012, J CEREBR BLOOD F MET, V32, P537, DOI 10.1038/jcbfm.2011.161
   Li G, 2017, P NATL ACAD SCI USA, V114, pE4288, DOI 10.1073/pnas.1617205114
   Li J, 2015, CELL BIOCHEM BIOPHYS, V71, P315, DOI 10.1007/s12013-014-0200-5
   Lim XR, 2024, NAT COMMUN, V15, DOI 10.1038/s41467-024-52969-0
   Lionetti V, 2021, PHARMACOL RES, V168, DOI 10.1016/j.phrs.2021.105581
   Lions S, 2018, J CRIT CARE, V46, P151, DOI 10.1016/j.jcrc.2018.03.014
   Liu JX, 2024, FRONT CARDIOVASC MED, V11, DOI 10.3389/fcvm.2024.1304864
   Locatelli F, 2021, J NEUROSCI, V41, P3307, DOI 10.1523/JNEUROSCI.3013-19.2020
   Longden TA, 2021, SCI ADV, V7, DOI 10.1126/sciadv.abh0101
   Longden TA, 2017, NAT NEUROSCI, V20, P717, DOI 10.1038/nn.4533
   López-Taboada I, 2020, FRONT PSYCHOL, V11, DOI 10.3389/fpsyg.2020.564413
   Lossnitzer N, 2013, INT J CARDIOL, V167, P502, DOI 10.1016/j.ijcard.2012.01.062
   Lu ZW, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0278398
   Lüscher C, 2012, CSH PERSPECT BIOL, V4, DOI 10.1101/cshperspect.a005710
   Mackey-Alfonso SE, 2024, BRAIN BEHAV IMMUN, V121, P56, DOI 10.1016/j.bbi.2024.07.021
   Maione AS, 2022, J TRANSL MED, V20, DOI 10.1186/s12967-022-03742-8
   Majimbi M, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1224418
   Malenka RC, 2004, NEURON, V44, P5, DOI 10.1016/j.neuron.2004.09.012
   Manolis AA, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms242015472
   Mapelli L, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23073894
   Marks AR, 2023, J CLIN INVEST, V133, DOI 10.1172/JCI162891
   Marques DM, 2023, NEUROCHEM RES, V48, P2424, DOI 10.1007/s11064-023-03917-9
   Matsumoto T, 2017, EUR J PHARMACOL, V807, P151, DOI 10.1016/j.ejphar.2017.03.062
   Medin T, 2013, NEUROSCIENCE, V242, P11, DOI 10.1016/j.neuroscience.2013.03.036
   Mei JQ, 2024, TRANSL NEURODEGENER, V13, DOI 10.1186/s40035-024-00431-y
   Mene-Afejuku TO, 2019, CURR CARDIOL REV, V15, P291, DOI 10.2174/1573403X15666190313112841
   Min JA, 2011, NEUROSCI LETT, V500, P52, DOI 10.1016/j.neulet.2011.05.239
   Moccia F, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms242316765
   Moccia F, 2023, J CLIN MED, V12, DOI 10.3390/jcm12165295
   Moccia F, 2023, FRONT PHYSIOL, V14, DOI 10.3389/fphys.2023.1210085
   Moccia F, 2023, CELLS-BASEL, V12, DOI 10.3390/cells12091261
   Moccia F, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24043259
   Moccia F, 2022, VASC PHARMACOL, V145, DOI 10.1016/j.vph.2022.106997
   Moccia F, 2020, CURR MED CHEM, V27, P240, DOI [10.2174/092986732666190905142135, 10.2174/0929867326666190905142135]
   Moccia F, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20163986
   Momeni Z, 2021, PHYSIOL BEHAV, V229, DOI 10.1016/j.physbeh.2020.113255
   Mone P, 2024, PHARMACOL RES, V200, DOI 10.1016/j.phrs.2023.107055
   Mone P, 2022, DIABETES CARE, V45, P1247, DOI 10.2337/dc21-2434
   Mone P, 2022, J CLIN HYPERTENS, V24, P638, DOI 10.1111/jch.14439
   Montgomery JM, 2002, NEURON, V33, P765, DOI 10.1016/S0896-6273(02)00606-2
   Morrison CD, 2010, J NEUROCHEM, V114, P1581, DOI 10.1111/j.1471-4159.2010.06865.x
   Nagayach A, 2024, AGEING RES REV, V100, DOI 10.1016/j.arr.2024.102450
   Naomi R, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12051071
   Navakkode S, 2022, TRANSL PSYCHIAT, V12, DOI 10.1038/s41398-021-01683-2
   Negri S, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22189821
   Negri S, 2021, CELL CALCIUM, V99, DOI 10.1016/j.ceca.2021.102454
   Negri S, 2021, INT J BIOCHEM CELL B, V135, DOI 10.1016/j.biocel.2021.105983
   Negri S, 2020, CELL MOL LIFE SCI, V77, P2235, DOI 10.1007/s00018-019-03284-1
   Newpher TM, 2009, TRENDS CELL BIOL, V19, P218, DOI 10.1016/j.tcb.2009.02.004
   Nguyen MN, 2017, COMPR PHYSIOL, V7, P1009, DOI 10.1002/cphy.c160046
   Nisticò R, 2012, NEUROMOL MED, V14, P262, DOI 10.1007/s12017-012-8184-z
   Noriega-Prieto JA, 2024, FRONT CELL NEUROSCI, V18, DOI 10.3389/fncel.2024.1390663
   Nowaczewska M, 2019, DIABETES RES CLIN PR, V153, P1, DOI 10.1016/j.diabres.2019.05.024
   O'Riordan K, 2014, HIPPOCAMPUS, V24, P1, DOI 10.1002/hipo.22222
   OCONNOR JJ, 1995, J NEUROSCI, V15, P2013, DOI 10.1523/JNEUROSCI.15-03-02013.1995
   Olmo BMG, 2023, NPJ SCI FOOD, V7, DOI 10.1038/s41538-023-00211-4
   Ortiz GG, 2022, WORLD J DIABETES, V13, P319, DOI 10.4239/wjd.v13.i4.319
   Osteraas ND, 2017, HAND CLINIC, V140, P49, DOI 10.1016/B978-0-444-63600-3.00004-0
   Otsuka H, 2024, NEUROSCI LETT, V822, DOI 10.1016/j.neulet.2024.137650
   Pacholko A, 2024, HYPERTENSION, V81, P991, DOI 10.1161/HYPERTENSIONAHA.123.21356
   Pan XN, 2017, FRONT BEHAV NEUROSCI, V11, DOI 10.3389/fnbeh.2017.00185
   Parent MB, 2021, BEHAV BRAIN RES, V414, DOI 10.1016/j.bbr.2021.113452
   Park M, 2004, SCIENCE, V305, P1972, DOI 10.1126/science.1102026
   Paulo SL, 2021, CURR ISSUES MOL BIOL, V43, P2305, DOI 10.3390/cimb43030162
   Perry Guy M L, 2010, Behav Brain Funct, V6, P56, DOI 10.1186/1744-9081-6-56
   Peters EC, 2022, J CEREBR BLOOD F MET, V42, P145, DOI 10.1177/0271678X211039592
   Polidori MC, 2001, AGING CLIN EXP RES, V13, P231, DOI 10.1007/BF03351481
   Poorgholam P, 2023, METAB BRAIN DIS, V38, P1925, DOI 10.1007/s11011-023-01200-y
   Porter D, 2012, PEPTIDES, V35, P1, DOI 10.1016/j.peptides.2012.03.014
   Potapenko ES, 2011, J NEUROPHYSIOL, V106, P1545, DOI 10.1152/jn.00218.2011
   Rajgor D, 2020, CELL REP, V31, DOI 10.1016/j.celrep.2020.107785
   Ramsey MM, 2004, NEUROSCIENCE, V129, P119, DOI 10.1016/j.neuroscience.2004.08.001
   Rebola N, 2008, NEURON, V57, P121, DOI 10.1016/j.neuron.2007.11.023
   Reisi Parham, 2010, Pathophysiology, V17, P33, DOI 10.1016/j.pathophys.2009.06.001
   Bueno JAR, 2024, J ALZHEIMERS DIS, V99, P887, DOI 10.3233/JAD-230791
   Rojas M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13072254
   Rossier BC, 2017, PHYSIOLOGY, V32, P112, DOI 10.1152/physiol.00026.2016
   Sa-Nguanmoo P, 2017, TOXICOL APPL PHARM, V333, P43, DOI 10.1016/j.taap.2017.08.005
   Sachdev PS, 2007, AM J GERIAT PSYCHIAT, V15, P487, DOI 10.1097/JGP.0b013e3180581fe6
   Saeed A, 2023, J AM HEART ASSOC, V12, DOI 10.1161/JAHA.123.030780
   Sagvolden T, 2009, NEUROPHARMACOLOGY, V57, P619, DOI 10.1016/j.neuropharm.2009.08.004
   Sahel A, 2023, J CLIN MED, V12, DOI 10.3390/jcm12165264
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sanderson JL, 2022, NEUROPHARMACOLOGY, V220, DOI 10.1016/j.neuropharm.2022.109271
   Sasaki-Hamada S, 2012, NEUROSCIENCE, V227, P293, DOI 10.1016/j.neuroscience.2012.09.081
   Sasaki-Hamada S, 2021, NEUROSCI RES, V170, P201, DOI 10.1016/j.neures.2020.08.005
   Sasaki-Hamada S, 2015, EUR J NEUROSCI, V41, P1393, DOI 10.1111/ejn.12891
   Sauvé MJ, 2009, J CARD FAIL, V15, P1, DOI 10.1016/j.cardfail.2008.08.007
   Savarese G, 2022, CARDIOVASC RES, V118, P3272, DOI 10.1093/cvr/cvac013
   Scheinman SB, 2024, MOL NEUROBIOL, V61, P120, DOI 10.1007/s12035-023-03556-9
   SELIG DK, 1995, NEURON, V15, P417, DOI 10.1016/0896-6273(95)90045-4
   Servili E, 2020, PROG NEUROBIOL, V191, DOI 10.1016/j.pneurobio.2020.101820
   Servili E, 2019, CELL CALCIUM, V84, DOI 10.1016/j.ceca.2019.102102
   Sgritta M, 2017, J NEUROSCI, V37, P2809, DOI 10.1523/JNEUROSCI.2079-16.2016
   Shoham S, 2003, EXP NEUROL, V184, P1043, DOI 10.1016/j.expneurol.2003.08.015
   Silva DS, 2021, J STROKE CEREBROVASC, V30, DOI 10.1016/j.jstrokecerebrovasdis.2021.105887
   Soda T, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24043914
   Soda T, 2019, J NEUROSCI, V39, P2383, DOI 10.1523/JNEUROSCI.1985-18.2019
   Solis-Urra P, 2024, PEDIATR RES, V95, P1812, DOI 10.1038/s41390-023-02923-5
   Song Juhyun, 2024, J Lipid Atheroscler, V13, P122, DOI 10.12997/jla.2024.13.2.122
   Song J, 2023, BIOMED PHARMACOTHER, V162, DOI 10.1016/j.biopha.2023.114647
   Splawski I, 2004, CELL, V119, P19, DOI 10.1016/j.cell.2004.09.011
   Srinivas S, 2024, CUREUS J MED SCIENCE, V16, DOI 10.7759/cureus.57159
   Stranahan AM, 2008, HIPPOCAMPUS, V18, P1085, DOI 10.1002/hipo.20470
   Tahsili-Fahadan P, 2017, CIRC RES, V120, P559, DOI 10.1161/CIRCRESAHA.116.308446
   Tapella L, 2020, GLIA, V68, P543, DOI 10.1002/glia.23737
   Tarantini S, 2018, J GERONTOL A-BIOL, V73, P853, DOI 10.1093/gerona/glx177
   Taylor JL, 2024, MICROCIRCULATION, V31, DOI 10.1111/micc.12881
   Testai FD, 2024, STROKE, V55, pe425, DOI 10.1161/STR.0000000000000476
   Thornton PL, 2000, J GERONTOL A-BIOL, V55, pB106
   Toledo C, 2019, MOL NEUROBIOL, V56, P8035, DOI 10.1007/s12035-019-01655-0
   Traynelis SF, 2010, PHARMACOL REV, V62, P405, DOI 10.1124/pr.109.002451
   Treviño S, 2015, SYNAPSE, V69, P421, DOI 10.1002/syn.21832
   Trudeau F, 2004, EUR J PHARMACOL, V490, P177, DOI 10.1016/j.ejphar.2004.02.055
   Tu LL, 2019, EXP THER MED, V18, P2429, DOI 10.3892/etm.2019.7868
   Tucsek Z, 2017, GEROSCIENCE, V39, P385, DOI 10.1007/s11357-017-9981-y
   Ungvari Z, 2021, NAT REV NEPHROL, V17, P639, DOI 10.1038/s41581-021-00430-6
   Valastro B, 2002, DIABETOLOGIA, V45, P642, DOI 10.1007/s00125-002-0818-5
   Valcarcel-Ares MN, 2019, J GERONTOL A-BIOL, V74, P290, DOI 10.1093/gerona/gly127
   Vallabhajosyula S, 2019, J AM COLL CARDIOL, V73, P1781, DOI 10.1016/j.jacc.2019.01.053
   Valladolid-Acebes I, 2012, AM J PHYSIOL-ENDOC M, V302, pE396, DOI 10.1152/ajpendo.00343.2011
   Varela EV, 2019, NEUROBIOL DIS, V127, P605, DOI 10.1016/j.nbd.2019.04.010
   Varrias D, 2024, BIOMOLECULES, V14, DOI 10.3390/biom14040455
   Vouimba RM, 2021, HIPPOCAMPUS, V31, P117, DOI 10.1002/hipo.23278
   Wang HY, 2024, ISCIENCE, V27, DOI 10.1016/j.isci.2024.109515
   Wang H, 2018, NEUROPHARMACOLOGY, V131, P143, DOI 10.1016/j.neuropharm.2017.12.026
   Wang L, 2024, FASEB J, V38, DOI 10.1096/fj.202301699RR
   Wang M, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-87809-4
   Wang YM, 2022, NEUROSCI LETT, V777, DOI 10.1016/j.neulet.2022.136587
   WAYNER MJ, 1993, PHARMACOL BIOCHEM BE, V45, P455, DOI 10.1016/0091-3057(93)90265-U
   Westhoff TH, 2011, J HUM HYPERTENS, V25, P256, DOI 10.1038/jhh.2010.51
   Wild AR, 2019, CELL REP, V26, P3537, DOI 10.1016/j.celrep.2019.03.005
   Wilson C, 2020, METABOLISM, V111, DOI 10.1016/j.metabol.2020.154340
   Woo MA, 2003, J APPL PHYSIOL, V95, P677, DOI 10.1152/japplphysiol.00101.2003
   Woo MA, 2015, J NEUROSCI RES, V93, P678, DOI 10.1002/jnr.23525
   XIAO MY, 1994, EUR J NEUROSCI, V6, P1055, DOI 10.1111/j.1460-9568.1994.tb00600.x
   Xu P, 2019, PHYSIOL GENOMICS, V51, P432, DOI 10.1152/physiolgenomics.00006.2019
   Yang J, 2015, AM J ALZHEIMERS DIS, V30, P201, DOI 10.1177/1533317514545379
   Yang MX, 2022, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.831734
   Yasuda R, 2022, NAT REV NEUROSCI, V23, P666, DOI 10.1038/s41583-022-00624-2
   Yeomans MR, 2017, P NUTR SOC, V76, P455, DOI 10.1017/S0029665117000805
   Yin HJ, 2017, J ALZHEIMERS DIS, V57, P1207, DOI 10.3233/JAD-160858
   Yong J, 2024, BIOMED PHARMACOTHER, V175, DOI 10.1016/j.biopha.2024.116688
   Youn YJ, 2024, FRONT NEUROENDOCRIN, V73, DOI 10.1016/j.yfrne.2024.101131
   Zhang HY, 2020, FRONT SYNAPTIC NEURO, V12, DOI 10.3389/fnsyn.2020.00026
   Zhang S, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1192602
   Zhang W, 2021, NEUROSCIENCE, V470, P88, DOI 10.1016/j.neuroscience.2021.06.037
   Zhang-James Y, 2012, DEV NEUROSCI-BASEL, V34, P218, DOI 10.1159/000338813
   Zhang-James Y, 2011, AM J MED GENET B, V156B, P835, DOI 10.1002/ajmg.b.31229
   Zhou Z, 2024, CURR HYPERTENS REP, V26, P1, DOI 10.1007/s11906-023-01266-0
   Zhuang YY, 2021, WORLD NEUROSURG, V149, P461, DOI 10.1016/j.wneu.2020.11.120
   Zuccolo E, 2019, J CELL PHYSIOL, V234, P3538, DOI 10.1002/jcp.26953
NR 271
TC 2
Z9 2
U1 11
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD OCT
PY 2024
VL 12
IS 10
AR 2387
DI 10.3390/biomedicines12102387
PG 24
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA K3M1Q
UT WOS:001342941600001
PM 39457698
OA gold
DA 2025-06-11
ER

PT J
AU Grillo, CA
   Mulder, P
   Macht, VA
   Kaigler, KF
   Wilson, SP
   Wilson, MA
   Reagan, LP
AF Grillo, Claudia A.
   Mulder, Petra
   Macht, Victoria A.
   Kaigler, Kris F.
   Wilson, Steven P.
   Wilson, Marlene A.
   Reagan, Lawrence P.
TI Dietary restriction reverses obesity-induced anhedonia
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Leptin; Triglycerides; Pro-inflammatory cytokines; Metabolic syndrome;
   Depressive illness
ID INSULIN-RECEPTOR EXPRESSION; GASTRIC BYPASS-SURGERY; C-REACTIVE PROTEIN;
   QUALITY-OF-LIFE; DEPRESSIVE SYMPTOMS; RANDOMIZED-TRIAL; DOWN-REGULATION;
   MOOD DISORDERS; YOUNG FINNS; WEIGHT-LOSS
AB Obesity-induced changes in the metabolic and endocrine milieu elicit deficits in neuroplasticity, including increased risk for development of neuropsychiatric disorders such as depressive illness. We previously demonstrated that downregulation of hypothalamic insulin receptors (hypo-IRAS) elicits a phenotype that is consistent with features of the metabolic syndrome (MetS) and that rats with this phenotype exhibit deficits in neuronal plasticity, including depressive-like behaviors such as anhedonia. Since food restriction paradigms effectively inhibit obesity-induced neuroplasticity deficits, the aim of the current study was to determine whether food restriction could reverse obesity-induced anhedonia in hypo-IRAS rats. Compared to hypo-IRAS rats provided ad lib food access, food restriction paradigms that were initiated either prior to increases in body weight or following development of the MetS/obesity phenotype effectively restored sucrose intake in hypo-IRAS rats. Moreover, food restriction paradigms were able to prevent and reverse the changes in the endocrine/metabolic/inflammatory milieu observed in hypo-IRAS, such as increases in plasma leptin and triglyceride levels and increases in pro-inflammatory cytokines such as IL-1 alpha, IL-6 and C-reactive protein (CRP). Collectively, these results demonstrate that obesity-induced anhedonia is a reversible process and identify some potential mechanistic mediators that may be responsible for co-morbid depression in obesity. Published by Elsevier Inc.
C1 [Grillo, Claudia A.; Mulder, Petra; Macht, Victoria A.; Kaigler, Kris F.; Wilson, Steven P.; Wilson, Marlene A.; Reagan, Lawrence P.] Univ S Carolina, Sch Med, Dept Pharmacol Physiol & Neurosci, Columbia, SC 29208 USA.
   [Wilson, Marlene A.; Reagan, Lawrence P.] WJB Dorn Vet Affairs Med Ctr, Columbia, SC USA.
C3 University of South Carolina System; University of South Carolina
   Columbia
RP Reagan, LP (corresponding author), Univ S Carolina, Sch Med, Dept Pharmacol Physiol & Neurosci, 6439 Garners Ferry Rd,Room D40, Columbia, SC 29208 USA.
EM lpreagan@uscmed.sc.edu
RI A Wilson, Marlene/JRW-2264-2023; Grillo, Claudia/J-6373-2012
OI Grillo, Claudia/0000-0001-9599-7234; Wilson,
   Marlene/0000-0003-4770-9669; Mulder, Petra/0000-0002-0982-4466
FU Department of Veterans Affairs [IO1 BX001804-01]; National Institutes of
   Health [R01 MH063344]; University of South Carolina Research Foundation
FX This work was supported by the Department of Veterans Affairs (IO1
   BX001804-01; LPR), the National Institutes of Health (R01 MH063344; MAW)
   and the University of South Carolina Research Foundation.
CR Andersen JR, 2010, HEALTH QUAL LIFE OUT, V8, DOI 10.1186/1477-7525-8-52
   Brüning JC, 2000, SCIENCE, V289, P2122, DOI 10.1126/science.289.5487.2122
   Capuron L, 2011, PSYCHOL MED, V41, P1517, DOI 10.1017/S0033291710001984
   Capuron L, 2008, BIOL PSYCHIAT, V64, P896, DOI 10.1016/j.biopsych.2008.05.019
   Capuron L, 2011, PHARMACOL THERAPEUT, V130, P226, DOI 10.1016/j.pharmthera.2011.01.014
   Collin M, 2000, MOL BRAIN RES, V81, P51, DOI 10.1016/S0169-328X(00)00167-4
   Daly M, 2013, OBESITY, V21, P248, DOI 10.1002/oby.20051
   Dantzer R, 2006, NEUROL CLIN, V24, P441, DOI 10.1016/j.ncl.2006.03.003
   de Zwaan M, 2011, J AFFECT DISORDERS, V133, P61, DOI 10.1016/j.jad.2011.03.025
   Dixon JB, 2003, ARCH INTERN MED, V163, P2058, DOI 10.1001/archinte.163.17.2058
   Dortland AKBV, 2013, PSYCHONEUROENDOCRINO, V38, P209, DOI 10.1016/j.psyneuen.2012.05.017
   Dortland AKBV, 2010, J CLIN PSYCHIAT, V71, P729, DOI 10.4088/JCP.08m04865blu
   Dymek MP, 2002, OBES RES, V10, P1135, DOI 10.1038/oby.2002.154
   Elovainio M, 2006, PSYCHOL MED, V36, P797, DOI 10.1017/S0033291706007574
   Elovainio M, 2010, HEALTH PSYCHOL, V29, P237, DOI 10.1037/a0018875
   Emery CF, 2007, OBES SURG, V17, P759, DOI 10.1007/s11695-007-9140-0
   Fabricatore AN, 2006, ANNU REV CLIN PSYCHO, V2, P357, DOI 10.1146/annurev.clinpsy.2.022305.095249
   Faulconbridge LF, 2009, OBESITY, V17, P1009, DOI 10.1038/oby.2008.647
   Grillo CA, 2007, PHYSIOL BEHAV, V92, P691, DOI 10.1016/j.physbeh.2007.05.043
   Grillo CA, 2011, BEHAV BRAIN RES, V222, P230, DOI 10.1016/j.bbr.2011.03.052
   Grillo CA, 2011, PHYSIOL BEHAV, V105, P138, DOI 10.1016/j.physbeh.2011.02.028
   Grillo CA, 2011, PHYSIOL BEHAV, V104, P235, DOI 10.1016/j.physbeh.2010.10.020
   Hamer M, 2012, MOL PSYCHIATR, V17, P940, DOI 10.1038/mp.2012.30
   Karlsson J, 2007, INT J OBESITY, V31, P1248, DOI 10.1038/sj.ijo.0803573
   Ladwig KH, 2003, BRAIN BEHAV IMMUN, V17, P268, DOI 10.1016/S0889-1591(03)00056-4
   Lu XY, 2007, CURR OPIN PHARMACOL, V7, P648, DOI 10.1016/j.coph.2007.10.010
   Lu XY, 2006, P NATL ACAD SCI USA, V103, P1593, DOI 10.1073/pnas.0508901103
   Lumeng CN, 2011, J CLIN INVEST, V121, P2111, DOI 10.1172/JCI57132
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   McElroy SL, 2004, J CLIN PSYCHIAT, V65, P634
   Morris AA, 2012, PSYCHOSOM MED, V74, P483, DOI 10.1097/PSY.0b013e31824f5de0
   Obici S, 2002, NAT NEUROSCI, V5, P566, DOI 10.1038/nn861
   Onyike CU, 2003, AM J EPIDEMIOL, V158, P1139, DOI 10.1093/aje/kwg275
   Paranjape SA, 2011, AM J PHYSIOL-ENDOC M, V301, pE978, DOI 10.1152/ajpendo.00304.2011
   Raison CL, 2013, JAMA PSYCHIAT, V70, P31, DOI 10.1001/2013.jamapsychiatry.4
   Raison CL, 2006, TRENDS IMMUNOL, V27, P24, DOI 10.1016/j.it.2005.11.006
   Reagan LP, 2012, EXP NEUROL, V233, P68, DOI 10.1016/j.expneurol.2011.02.004
   Sharma AN, 2010, PHYSIOL BEHAV, V101, P381, DOI 10.1016/j.physbeh.2010.07.002
   Shelton RC, 2010, PROG NEUROBIOL, V91, P275, DOI 10.1016/j.pneurobio.2010.04.004
   Simon GE, 2006, ARCH GEN PSYCHIAT, V63, P824, DOI 10.1001/archpsyc.63.7.824
   Soczynska JK, 2011, NEUROMOL MED, V13, P93, DOI 10.1007/s12017-010-8140-8
   Stunkard AJ, 2003, BIOL PSYCHIAT, V54, P330, DOI 10.1016/S0006-3223(03)00608-5
   Wadden TA, 2005, NEW ENGL J MED, V353, P2111, DOI 10.1056/NEJMoa050156
   Yamada N, 2011, ENDOCRINOLOGY, V152, P2634, DOI 10.1210/en.2011-0004
   Zhao WQ, 1999, J BIOL CHEM, V274, P34893, DOI 10.1074/jbc.274.49.34893
   Zhao WQ, 2001, MOL CELL ENDOCRINOL, V177, P125, DOI 10.1016/S0303-7207(01)00455-5
NR 46
TC 25
Z9 27
U1 3
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD APR 10
PY 2014
VL 128
BP 126
EP 132
DI 10.1016/j.physbeh.2014.01.026
PG 7
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA AG0LE
UT WOS:000335106200019
PM 24518861
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Cardinali, DP
   Brown, GM
   Pandi-Perumal, SR
AF Cardinali, Daniel P.
   Brown, Gregory M.
   Pandi-Perumal, Seithikurippu R.
TI Can Melatonin Be a Potential "Silver Bullet" in Treating COVID-19
   Patients?
SO DISEASES
LA English
DT Review
DE aging; anti-SARS-CoV-2 vaccination; chronotherapy; COVID-19 pandemic;
   cytoprotection; diabetes; inflammation; metabolic syndrome; melatonin;
   cognitive impairment; neurodegeneration; oxidative stress;
   renin-angiotensin system
ID RENIN-ANGIOTENSIN SYSTEM; SLEEP DISTURBANCES; OXIDATIVE STRESS;
   INHIBITION; EXPRESSION; MOLECULE; DELIRIUM; DISEASE; CANCER; CELLS
AB The therapeutic potential of melatonin as a chronobiotic cytoprotective agent to counteract the consequences of COVID-19 infections has been advocated. Because of its wide-ranging effects as an antioxidant, anti-inflammatory, and immunomodulatory compound, melatonin could be unique in impairing the consequences of SARS-CoV-2 infection. Moreover, indirect evidence points out to a possible antiviral action of melatonin by interfering with SARS-CoV-2/angiotensin-converting enzyme 2 association. Melatonin is also an effective chronobiotic agent to reverse the circadian disruption of social isolation and to control delirium in severely affected patients. As a cytoprotector, melatonin serves to combat several comorbidities such as diabetes, metabolic syndrome, and ischemic and non-ischemic cardiovascular diseases, which aggravate COVID-19 disease. In view of evidence on the occurrence of neurological sequels in COVID-19-infected patients, another putative application of melatonin emerges based on its neuroprotective properties. Since melatonin is an effective means to control cognitive decay in minimal cognitive impairment, its therapeutic significance for the neurological sequels of SARS-CoV-2 infection should be considered. Finally, yet importantly, exogenous melatonin can be an adjuvant capable of augmenting the efficacy of anti-SARS-CoV-2 vaccines. We discuss in this review the experimental evidence suggesting that melatonin is a potential "silver bullet" in the COVID 19 pandemic.
C1 [Cardinali, Daniel P.] Pontificia Univ Catolica Argentina, Fac Med Sci, RA-1007 Buenos Aires, DF, Argentina.
   [Brown, Gregory M.] Univ Toronto, Dept Psychiat, Ctr Addict & Mental Hlth, Toronto, ON M5T 1R8, Canada.
   [Pandi-Perumal, Seithikurippu R.] Somnogen Canada Inc, Coll St, Toronto, ON M6H 1C5, Canada.
C3 Pontificia Universidad Catolica Argentina; University of Toronto; Centre
   for Addiction & Mental Health - Canada
RP Pandi-Perumal, SR (corresponding author), Somnogen Canada Inc, Coll St, Toronto, ON M6H 1C5, Canada.
EM daniel_cardinali@uca.edu.ar; gregory.brown@camh.ca;
   Pandiperumal2020@gmail.com
RI Pandi-Perumal, Seithikurippu/Q-8281-2016; Brown, Gregory/ACV-1983-2022;
   Pandi-Perumal, Seithikurippu R/C-6767-2008
OI Pandi-Perumal, Seithikurippu R/0000-0002-8686-7259
CR Abbas A., 2019, Basic Immunology, V6th
   Acuña-Castroviejo D, 2014, CELL MOL LIFE SCI, V71, P2997, DOI 10.1007/s00018-014-1579-2
   Ahmadi Z, 2020, FUND CLIN PHARMACOL, V34, P11, DOI 10.1111/fcp.12498
   Al-Waeli H, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-019-57215-y
   Al-Zaqri N, 2020, J MOL LIQ, V318, DOI 10.1016/j.molliq.2020.114082
   Alexopoulos H, 2020, NEUROL-NEUROIMMUNOL, V7, DOI 10.1212/NXI.0000000000000893
   Anderson G, 2015, J MED VIROL, V87, P537, DOI 10.1002/jmv.24130
   Antony PA, 2005, J IMMUNOTHER, V28, P120, DOI 10.1097/01.cji.0000155049.26787.45
   Arendse LB, 2019, PHARMACOL REV, V71, P539, DOI 10.1124/pr.118.017129
   Bald T, 2020, NAT IMMUNOL, V21, P835, DOI 10.1038/s41590-020-0728-z
   Ballesta A, 2017, PHARMACOL REV, V69, P161, DOI 10.1124/pr.116.013441
   Bazyar H, 2019, INFLAMMOPHARMACOLOGY, V27, P67, DOI 10.1007/s10787-018-0539-0
   BenitezKing G, 1996, BBA-GEN SUBJECTS, V1290, P191, DOI 10.1016/0304-4165(96)00025-6
   BENITEZKING G, 1993, LIFE SCI, V53, P201, DOI 10.1016/0024-3205(93)90670-X
   Brivio F, 2008, IN VIVO, V22, P647
   Campos LA, 2013, INT J HYPERTENS, V2013, DOI 10.1155/2013/521783
   Cardinali D. P, 2019, Melatonin Research, V2, P106, DOI [10.32794/mr11250025, DOI 10.32794/MR11250025]
   Cardinali D.P., 2020, Melatonin Res, V3, P311, DOI [10.32794/mr11250064, DOI 10.32794/MR11250064]
   Cardinali Daniel P, 2020, Sleep Vigil, V4, P81, DOI 10.1007/s41782-020-00111-7
   Cardinali DP, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00480
   Cardinali DP, 2019, BIOL RHYTHM RES, V50, P28, DOI 10.1080/09291016.2018.1491200
   Cardinali DP, 2017, NEUROENDOCRINOLOGY, V104, P382, DOI 10.1159/000446543
   Cardinali DP, 2014, ANTIOXIDANTS, V3, P245, DOI 10.3390/antiox3020245
   Cardinali Daniel P, 2012, Am J Neurodegener Dis, V1, P280
   Cardinali DP, 2008, NEUROIMMUNOMODULAT, V15, P272, DOI 10.1159/000156470
   Cardinali DP, 1998, BRAIN RES, V789, P283, DOI 10.1016/S0006-8993(98)00015-8
   Carrillo-Vico A, 2013, INT J MOL SCI, V14, P8638, DOI 10.3390/ijms14048638
   Castillo R.R., 2020, MELATONIN RES, V3, P310, DOI 10.32794
   Castrillón PO, 2000, J NEUROENDOCRINOL, V12, P758, DOI 10.1046/j.1365-2826.2000.00519.x
   Cederroth CR, 2019, CELL METAB, V30, P238, DOI 10.1016/j.cmet.2019.06.019
   Chellappa SL, 2019, TRENDS ENDOCRIN MET, V30, P767, DOI 10.1016/j.tem.2019.07.008
   Chen J, 2019, BIOMED PHARMACOTHER, V117, DOI 10.1016/j.biopha.2019.109150
   Chen NS, 2020, LANCET, V395, P507, DOI 10.1016/S0140-6736(20)30211-7
   Chow N, 2020, MMWR-MORBID MORTAL W, V69, P382, DOI 10.15585/mmwr.mm6913e2
   Codo AC, 2020, CELL METAB, V32, P437, DOI 10.1016/j.cmet.2020.07.007
   Cornelissen G, 2017, GERONTOLOGY, V63, P118, DOI 10.1159/000450945
   Pedrosa AMD, 2010, J IMMUNOL, V184, P3487, DOI 10.4049/jimmunol.0902961
   Dai WL, 2019, INT J MOL MED, V44, P1197, DOI 10.3892/ijmm.2019.4306
   Damoiseaux J, 2020, CLIN IMMUNOL, V218, DOI 10.1016/j.clim.2020.108515
   Dawson D, 1996, PHARMACOL THERAPEUT, V69, P15, DOI 10.1016/0163-7258(95)02020-9
   Deng WG, 2006, BLOOD, V108, P518, DOI 10.1182/blood-2005-09-3691
   Duffy JF, 2015, SLEEP MED CLIN, V10, P423, DOI 10.1016/j.jsmc.2015.08.002
   El-Gendy FM, 2018, J MATERN-FETAL NEO M, V31, P2299, DOI 10.1080/14767058.2017.1342794
   Eraslan M, 2016, ACTA OPHTHALMOL, V94, pE68, DOI 10.1111/aos.12809
   Feitosa EL, 2020, INT J MED SCI, V17, P2133, DOI 10.7150/ijms.48053
   Foster RG, 2020, INTERFACE FOCUS, V10, DOI 10.1098/rsfs.2019.0098
   Galano A, 2011, J PINEAL RES, V51, P1, DOI 10.1111/j.1600-079X.2011.00916.x
   Gitto E, 2001, PEDIATR RES, V50, P756, DOI 10.1203/00006450-200112000-00021
   Gitto E, 2004, J PEDIATR SURG, V39, P184, DOI 10.1016/j.jpedsurg.2003.10.003
   Gitto E, 2004, J PINEAL RES, V36, P250, DOI 10.1111/j.1600-079X.2004.00124.x
   Grifoni A, 2020, CELL, V181, P1489, DOI 10.1016/j.cell.2020.05.015
   GRIMM EA, 1982, J EXP MED, V155, P1823, DOI 10.1084/jem.155.6.1823
   Gulia Kamalesh K, 2020, Sleep Vigil, V4, P49, DOI 10.1007/s41782-020-00087-4
   Gurwitz D, 2020, DRUG DEVELOP RES, V81, P537, DOI 10.1002/ddr.21656
   Hampshire A., 2020, COGNITIVE DEFICITS P, DOI [DOI 10.1101/2020.10.20.20215863, https://doi.org/10.1101/2020.10.20.20215863]
   Hardeland R, 2018, J PINEAL RES, V65, DOI 10.1111/jpi.12525
   Haspel JA, 2020, JCI INSIGHT, V5, DOI 10.1172/jci.insight.131487
   Horby P, 2021, NEW ENGL J MED, V384, P693, DOI [10.1056/NEJMoa2022926, 10.1056/NEJMoa2021436]
   Huang CL, 2020, LANCET, V395, P497, DOI 10.1016/S0140-6736(20)30183-5
   Jafari-Vayghan H, 2019, J CELL BIOCHEM, V120, P16340, DOI 10.1002/jcb.29151
   Jawaid A, 2020, SCIENCE, V368, P145, DOI 10.1126/science.abb7885
   Jehi L, 2020, CHEST, V158, P1364, DOI 10.1016/j.chest.2020.05.580
   Juybari KB, 2020, VIRUS RES, V287, DOI 10.1016/j.virusres.2020.198108
   Kleszczynski K, 2020, NUTRIENTS, V12, DOI 10.3390/nu12092561
   Korn T, 2009, ANNU REV IMMUNOL, V27, P485, DOI 10.1146/annurev.immunol.021908.132710
   Kremer S, 2020, RADIOLOGY, V297, pE242, DOI [10.1148/radiol.202020222, 10.1148/radiol.2020202222]
   Kryczek I, 2007, J IMMUNOL, V179, P1423, DOI 10.4049/jimmunol.179.3.1423
   Kücükakin B, 2008, J PINEAL RES, V44, P426, DOI 10.1111/j.1600-079X.2007.00545.x
   Lambert DW, 2008, FEBS LETT, V582, P385, DOI 10.1016/j.febslet.2007.11.085
   Lewandowska K, 2020, SLEEP MED, V69, P127, DOI 10.1016/j.sleep.2020.01.019
   Lewy A, 2006, CHRONOBIOL INT, V23, P403, DOI 10.1080/07420520500545862
   Madjid M, 2020, JAMA CARDIOL, V5, P831, DOI 10.1001/jamacardio.2020.1286
   Maestroni G, 2020, J NEUROIMMUNE PHARM, V15, P572, DOI 10.1007/s11481-020-09956-1
   MAESTRONI GJM, 1993, J PINEAL RES, V14, P1, DOI 10.1111/j.1600-079X.1993.tb00478.x
   Maestroni GJM, 1999, ADV EXP MED BIOL, V467, P217
   Manchester LC, 2015, J PINEAL RES, V59, P403, DOI 10.1111/jpi.12267
   Mao L, 2020, JAMA NEUROL, V77, P683, DOI 10.1001/jamaneurol.2020.1127
   Moreno ACR, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01914
   O'Neill S, 2015, OBES REV, V16, P1, DOI 10.1111/obr.12229
   Papachristodoulou E, 2020, PATHOG DIS, V78, DOI 10.1093/femspd/ftaa025
   Perrotta F, 2020, AGING CLIN EXP RES, V32, P1599, DOI 10.1007/s40520-020-01631-y
   Rahimi SB, 2018, ARCH VIROL, V163, P587, DOI 10.1007/s00705-017-3647-z
   Rahman A, 2019, HYPERTENS RES, V42, P920, DOI 10.1038/s41440-019-0223-9
   Raj V, 2018, AUTON NEUROSCI-BASIC, V215, P46, DOI 10.1016/j.autneu.2018.03.004
   Ramlall Vijendra, 2020, medRxiv, DOI 10.1101/2020.10.15.20213546
   Reagan-Shaw S, 2008, FASEB J, V22, P659, DOI 10.1096/fj.07-9574LSF
   Regodón S, 2005, VACCINE, V23, P5321, DOI 10.1016/j.vaccine.2005.07.003
   Reiter R.J., 2020, Melatonin Res, V3, P362, DOI [10.32794/mr11250068, DOI 10.32794/MR11250068]
   Reiter RJ, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19082439
   Roby C.A., 2005, WEREWOLVES CREATURES
   Rogers JP, 2020, LANCET PSYCHIAT, V7, P611, DOI 10.1016/S2215-0366(20)30203-0
   Romero A, 2022, CELL MOL NEUROBIOL, V42, P489, DOI 10.1007/s10571-020-00938-8
   Salluh J, 2015, BMJ-BRIT MED J, V350, DOI [10.1136/bmj.h2538, 10.1136/bmj.h3129]
   Sánchez-López AL, 2018, ARCH MED RES, V49, P391, DOI 10.1016/j.arcmed.2018.12.004
   Sengupta S, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-11400-9
   Shafiei E, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000011383
   Shang Y, 2009, CHINESE MED J-PEKING, V122, P1388, DOI 10.3760/cma.j.issn.0366-6999.2009.12.006
   Simko F, 2020, EXPERT REV CLIN PHAR, V13, P921, DOI 10.1080/17512433.2020.1814141
   Smith CJ, 2015, DIABETES METAB SYNDR, V8, P295, DOI 10.2147/DMSO.S61296
   Santos RAS, 2019, AM J PHYSIOL-HEART C, V316, pH958, DOI 10.1152/ajpheart.00723.2018
   Tan D.X., 2020, MELATONIN RES, V3, P120, DOI 10.32794/mr11250052
   Tseng YH, 2020, KAOHSIUNG J MED SCI, V36, P389, DOI 10.1002/kjm2.12237
   Venegas C, 2013, J PINEAL RES, V54, P313, DOI 10.1111/jpi.12019
   Volt H, 2016, J PINEAL RES, V60, P193, DOI 10.1111/jpi.12303
   Wells R, 2020, J ARRYTHM, V36, P549, DOI 10.1002/joa3.12325
   Wong SK, 2004, J BIOL CHEM, V279, P3197, DOI 10.1074/jbc.C300520200
   Xia YY, 2019, J PINEAL RES, V66, DOI 10.1111/jpi.12547
   Xu L, 2020, MED SCI MONITOR, V26, DOI 10.12659/MSM.923232
   Yan RH, 2020, SCIENCE, V367, P1444, DOI 10.1126/science.abb2762
   Yu ZX, 2015, CRIT CARE, V19, DOI 10.1186/s13054-015-0811-2
   Zaki NFW, 2018, EUR ARCH PSY CLIN N, V268, P107, DOI 10.1007/s00406-017-0835-5
   Zambrelli E, 2020, SLEEP MED, V70, P111, DOI 10.1016/j.sleep.2020.04.006
   Zanin L, 2020, ACTA NEUROCHIR, V162, P1491, DOI 10.1007/s00701-020-04374-x
   Zhang C, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.01295
   Zhang JB, 2020, J CELL PHYSIOL, V235, P2847, DOI 10.1002/jcp.29190
   Zhang QY, 2019, SLEEP BREATH, V23, P1059, DOI 10.1007/s11325-019-01831-5
   Zhang R, 2020, LIFE SCI, V250, DOI 10.1016/j.lfs.2020.117583
   Zhao ZW, 2018, J PINEAL RES, V65, DOI 10.1111/jpi.12521
   Zhou YD, 2020, PLOS BIOL, V18, DOI [10.1371/journal.pbio.3000970, 10.26434/chemrxiv.12579137.v1]
NR 119
TC 53
Z9 53
U1 0
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2079-9721
J9 DISEASES-BASEL
JI Diseases
PD DEC
PY 2020
VL 8
IS 4
AR 44
DI 10.3390/diseases8040044
PG 15
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA TY8FI
UT WOS:000684014900009
PM 33256258
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Limberg, JK
   Harrell, JW
   Johansson, RE
   Eldridge, MW
   Proctor, LT
   Sebranek, JJ
   Schrage, WG
AF Limberg, Jacqueline K.
   Harrell, John W.
   Johansson, Rebecca E.
   Eldridge, Marlowe W.
   Proctor, Lester T.
   Sebranek, Joshua J.
   Schrage, William G.
TI Microvascular function in younger adults with obesity and metabolic
   syndrome: role of oxidative stress
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE endothelial function; blood flow; prediabetes; nitric oxide;
   prostacyclin
ID HIGH-SALT DIET; ENDOTHELIAL DYSFUNCTION; NITRIC-OXIDE; SKELETAL-MUSCLE;
   ASCORBIC-ACID; ZUCKER RATS; MEDIATED VASODILATION; EXERCISE HYPEREMIA;
   INSULIN-RESISTANCE; HABITUAL EXERCISE
AB Older adults with cardiovascular disease exhibit microvascular dysfunction and increased levels of reactive oxygen species (ROS). We hypothesized that microvascular impairments begin early in the disease process and can be improved by scavenging ROS. Forearm blood flow (Doppler ultrasound) was measured in 45 young (32 +/- 2 yr old) adults (n = 15/group) classified as lean, obese, and metabolic syndrome (MetSyn). Vasodilation in response to endothelial (ACh) and vascular smooth muscle [nitroprusside (NTP) and epoprostenol (Epo)] agonists was tested before and after intra-arterial infusion of ascorbic acid to scavenge ROS. Vasodilation was assessed as a rise in relative vascular conductance (ml.min(-1).dl(-1).100 mmHg(-1)). ACh and NTP responses were preserved (P = 0.825 and P = 0.924, respectively), whereas Epo responses were lower in obese and MetSyn adults (P < 0.05) than in lean controls. Scavenging of ROS via infusion of ascorbic acid resulted in an increase in ACh-mediated (P < 0.001) and NTP-mediated (P < 0.001) relative vascular conductance across all groups, suggesting that oxidative stress influences vascular responsiveness in adults with and without overt cardiovascular disease risk. Ascorbic acid had no effect on Epo-mediated vasodilation (P = 0.267). These results suggest that obese and MetSyn adults exhibit preserved endothelium-dependent vasodilation with reduced dependence on prostacyclin and are consistent with an upregulation of compensatory vascular control mechanisms.
C1 [Limberg, Jacqueline K.; Harrell, John W.; Johansson, Rebecca E.; Eldridge, Marlowe W.; Schrage, William G.] Univ Wisconsin, Dept Kinesiol, Sch Educ, Madison, WI 53706 USA.
   [Eldridge, Marlowe W.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Populat Hlth Sci, John Rankin Lab Pulm Med, Madison, WI 53706 USA.
   [Eldridge, Marlowe W.] Univ Wisconsin Hosp & Clin, Dept Pediat, Madison, WI 53792 USA.
   [Proctor, Lester T.; Sebranek, Joshua J.] Univ Wisconsin Hosp & Clin, Dept Anesthesiol, Madison, WI 53792 USA.
C3 University of Wisconsin System; University of Wisconsin Madison;
   University of Wisconsin System; University of Wisconsin Madison;
   University of Wisconsin System; University of Wisconsin Madison;
   University Wisconsin Madison Hospital; University of Wisconsin System;
   University of Wisconsin Madison; University Wisconsin Madison Hospital
RP Schrage, WG (corresponding author), Univ Wisconsin, Dept Kinesiol, 1149A Natatorium, Madison, WI 53706 USA.
EM wschrage@education.wisc.edu
OI Johansson, Rebecca/0000-0002-0605-1293
FU American Heart Association [10PRE3870000, 11PRE7390038]; National Heart,
   Lung, and Blood Institute [HL-091397, HL-105820]; National Institutes of
   Health [RR-000167]; American Heart Association (AHA) [10PRE3870000,
   11PRE7390038] Funding Source: American Heart Association (AHA)
FX This study was supported by American Heart Association Predoctoral
   Awards 10PRE3870000 (J. K. Limberg) and 11PRE7390038 (J. W. Harrell) and
   National Heart, Lung, and Blood Institute Grants HL-091397 and HL-105820
   (W. G. Schrage). In addition, we acknowledge the involvement of
   Wisconsin National Primate Research Center Assay Services and the
   partial support of National Institutes of Health Grant RR-000167.
CR Acree Luke S, 2007, Dyn Med, V6, P4, DOI 10.1186/1476-5918-6-4
   Andrews TJ, 2000, J PHARM PHARMACOL, V52, P83, DOI 10.1211/0022357001773544
   Benzie IFF, 1996, INT J FOOD SCI NUTR, V47, P233, DOI 10.3109/09637489609012586
   Christou DD, 2012, AM J PHYSIOL-HEART C, V303, pH743, DOI 10.1152/ajpheart.00394.2012
   Crecelius AR, 2010, AM J PHYSIOL-HEART C, V299, pH1633, DOI 10.1152/ajpheart.00614.2010
   Davignon J, 2004, CIRCULATION, V109, P27, DOI 10.1161/01.CIR.0000131515.03336.f8
   Dell'Omo G, 2004, ATHEROSCLEROSIS, V172, P383, DOI 10.1016/j.atherosclerosis.2003.11.013
   Després JP, 2012, CIRCULATION, V126, P1301, DOI 10.1161/CIRCULATIONAHA.111.067264
   Eskurza I, 2001, AM J CARDIOL, V88, P1067, DOI 10.1016/S0002-9149(01)01997-X
   Frisbee JC, 2002, AM J PHYSIOL-HEART C, V283, pH2160, DOI 10.1152/ajpheart.00379.2002
   Frisbee JC, 2001, AM J PHYSIOL-HEART C, V281, pH1808, DOI 10.1152/ajpheart.2001.281.4.H1808
   Frisbee JC, 2006, ESSAYS BIOCHEM, V42, P145, DOI 10.1042/bse0420145
   Fujita K, 2006, CIRC J, V70, P1437, DOI 10.1253/circj.70.1437
   Green DJ, 2004, J APPL PHYSIOL, V97, P749, DOI 10.1152/japplphysiol.00109.2004
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Hodnett BL, 2008, MICROCIRCULATION, V15, P485, DOI 10.1080/10739680801942240
   Hodnett BL, 2009, AM J PHYSIOL-REG I, V296, pR715, DOI 10.1152/ajpregu.90330.2008
   Kirby BS, 2010, J PHYSIOL-LONDON, V588, P4017, DOI 10.1113/jphysiol.2010.197814
   Kirby BS, 2009, J PHYSIOL-LONDON, V587, P1989, DOI 10.1113/jphysiol.2008.167320
   Landmesser U, 2004, CIRCULATION, V109, P27, DOI 10.1161/01.CIR.0000129501.88485.1f
   Limberg JK, 2010, J APPL PHYSIOL, V108, P349, DOI 10.1152/japplphysiol.00551.2009
   Lteif AA, 2005, CIRCULATION, V112, P32, DOI 10.1161/CIRCULATIONAHA.104.520130
   Meyer MF, 2008, MICROVASC RES, V76, P61, DOI 10.1016/j.mvr.2008.03.001
   NAJIBI S, 1994, AM J PHYSIOL, V266, pH2061, DOI 10.1152/ajpheart.1994.266.5.H2061
   Nicholson WT, 2009, HYPERTENSION, V53, P973, DOI 10.1161/HYPERTENSIONAHA.108.121483
   Nielsen S, 2004, HYPERTENSION, V44, P435, DOI 10.1161/01.HYP.0000142111.67601.6b
   NISHIKIMI M, 1975, BIOCHEM BIOPH RES CO, V63, P463, DOI 10.1016/0006-291X(75)90710-X
   Perticone F, 2001, DIABETES, V50, P159, DOI 10.2337/diabetes.50.1.159
   RICEEVANS C, 1994, METHOD ENZYMOL, V234, P279
   Romero-Corral A, 2008, INT J OBESITY, V32, P959, DOI 10.1038/ijo.2008.11
   Schrage WG, 2005, J APPL PHYSIOL, V98, P1251, DOI 10.1152/japplphysiol.00966.2004
   Schubert R, 1997, AM J PHYSIOL-HEART C, V272, pH1147, DOI 10.1152/ajpheart.1997.272.3.H1147
   Seals DR, 2008, J APPL PHYSIOL, V105, P1323, DOI 10.1152/japplphysiol.90553.2008
   Seals DR, 2009, J PHYSIOL-LONDON, V587, P5541, DOI 10.1113/jphysiol.2009.178822
   SIEGEL G, 1992, ADV EXP MED BIOL, V311, P53
   Sivitz WI, 2007, J DIABETES COMPLICAT, V21, P149, DOI 10.1016/j.jdiacomp.2005.12.003
   Sofola OA, 2002, J PHYSIOL-LONDON, V543, P255, DOI 10.1113/jphysiol.2002.022277
   Steinberg HO, 1996, J CLIN INVEST, V97, P2601, DOI 10.1172/JCI118709
   Taddei S, 2001, HYPERTENSION, V38, P274, DOI 10.1161/01.HYP.38.2.274
   Taddei S, 2000, CIRCULATION, V101, P2896, DOI 10.1161/01.CIR.101.25.2896
   Tesauro M, 2005, CIRCULATION, V112, P2986, DOI 10.1161/CIRCULATIONAHA.105.553883
   Van Guilder GP, 2008, AM J PHYSIOL-HEART C, V294, pH1685, DOI 10.1152/ajpheart.01281.2007
   Villela Nivaldo Ribeiro, 2006, Clinics, V61, P53, DOI 10.1590/S1807-59322006000100010
   Weil BR, 2011, OBESITY, V19, P1742, DOI 10.1038/oby.2011.189
   Wolin Michael S., 1996, Microcirculation (Philadelphia), V3, P1, DOI 10.3109/10739689609146778
   Xiang LH, 2006, AM J PHYSIOL-REG I, V290, pR134, DOI 10.1152/ajpregu.00295.2005
NR 46
TC 33
Z9 35
U1 0
U2 13
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD OCT
PY 2013
VL 305
IS 8
BP H1230
EP H1237
DI 10.1152/ajpheart.00291.2013
PG 8
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 237KM
UT WOS:000325868600013
PM 23934859
OA Green Published
DA 2025-06-11
ER

PT J
AU Sengul, C
   Cevik, C
   Ozveren, O
   Duman, D
   Eroglu, E
   Oduncu, V
   Tanboga, HI
   Can, MM
   Akgun, T
   Dindar, I
AF Sengul, Cihan
   Cevik, Cihan
   Ozveren, Olcay
   Duman, Dursun
   Eroglu, Elif
   Oduncu, Vecih
   Tanboga, Halil Ibrahim
   Can, Mehmet Mustafa
   Akgun, Taylan
   Dindar, Ismet
TI Epicardial Fat Thickness Is Associated with Non-Dipper Blood Pressure
   Pattern in Patients with Essential Hypertension
SO CLINICAL AND EXPERIMENTAL HYPERTENSION
LA English
DT Article
DE epicardial fat; visceral adiposity; hypertension; echocardiography;
   non-dipper
ID LEFT-VENTRICULAR HYPERTROPHY; AUTONOMIC NERVOUS-SYSTEM; TARGET ORGAN
   DAMAGE; INSULIN-RESISTANCE; ADIPOSE-TISSUE; METABOLIC SYNDROME;
   NOCTURNAL FALL; ECHOCARDIOGRAPHY; ADIPONECTIN; SOCIETY
AB Objective. Epicardial fat tissue reflects visceral adiposity and is a suggested cardiometabolic risk factor. Patients with abdominal obesity have an increased prevalence of the non-dipper blood pressure (BP) pattern, but it is unclear whether the same is true of patients with increased epicardial fat thickness (EFT). The association between EFT and circadian BP changes in patients with recently diagnosed essential hypertension was examined. Methods. Sixty hypertensive patients underwent echocardiography, treadmill stress testing, and 24 hours of ambulatory BP monitoring. Epicardial fat thickness and left ventricular mass (LVM) index were measured by using transthoracic echocardiography. The patients were categorized into two groups according to their BP pattern (group 1, non-dippers; group 2, dippers). Results. The mean EFT and LVM of patients in group 1 (n = 24) (EFT, 7.6 +/- 2.1 mm; LVM, 130 +/- 31.2 g/m(2)) were significantly greater than those of group 2 (n = 36) (EFT, 5.5 +/- 1.2 mm, P = .0001; LVM, 107 +/- 23.7 g/m(2), P = .002). The average systolic BP over 24 hours (BPs 24) and average diastolic BP over 24 hours (BPd 24) of group 1 (BPs 24, 151.1 +/- 17.6 mm Hg; BPd 24, 94.1 +/- 16.5 mm Hg) were significantly higher than those of group 2 (BPs 24, 136.7 +/- 11.9 mm Hg, P = .0001; BPd 24, 84.6 +/- 10.6 mm Hg; P = .008). Multivariate backward logistic regression analysis demonstrated that the non-dipper BP pattern was associated with EFT (standardized beta coefficient = 0.87, P = .005) and LVM (standardized beta coefficient = 0.43, P = .016). An EFT = 7 mm was associated with the non-dipper BP pattern with 44% sensitivity and 94% specificity (receiver operating characteristic area under curve of 0.72, 95% CI [0.59-0.83], P = .0007). Conclusions. Epicardial fat thickness was above average in newly diagnosed, untreated hypertensive patients with non-dipper BP pattern. The echocardiographic measurement of EFT may be used to indicate increased risk of hypertension-related adverse cardiovascular events.
C1 [Cevik, Cihan] St Lukes Episcopal Hosp, Texas Heart Inst, Div Adult Cardiol, Houston, TX 77030 USA.
   [Sengul, Cihan; Dindar, Ismet] Goztepe Med Pk Hosp, Div Cardiol, Istanbul, Turkey.
   [Ozveren, Olcay; Eroglu, Elif; Oduncu, Vecih; Tanboga, Halil Ibrahim; Can, Mehmet Mustafa; Akgun, Taylan] Kartal Kosuyolu Heart & Res Hosp, Div Cardiol, Istanbul, Turkey.
   [Duman, Dursun] Haydarpasa Numune Training & Res Hosp, Div Cardiol, Istanbul, Turkey.
C3 Texas Heart Institute; Saint Lukes Episcopal Hospital; Medical Park
   Hospitals Group; Istanbul Kartal Kosuyolu Yuksek Ihtisas Training &
   Research Hospital; Istanbul Haydarpasa Numune Training & Research
   Hospital; Istanbul Haydarpasa Sultan Abdulhamid Training & Research
   Hospital
RP Cevik, C (corresponding author), St Lukes Episcopal Hosp, Texas Heart Inst, Div Adult Cardiol, Houston, TX 77030 USA.
EM ccevik@sleh.com
RI Tanboga, Ibrahim/E-8886-2010; Eroglu, Elif/T-7450-2017; Duman,
   Dursun/B-5558-2015; AKGUN, Taylan/ABH-8172-2020
OI Tanboga, Ibrahim Halil/0000-0003-4546-9227; AKGUN,
   Taylan/0000-0002-5395-2027; ODUNCU, Vecih/0000-0001-8221-9230
CR Anan F, 2003, HYPERTENS RES, V26, P669, DOI 10.1291/hypres.26.669
   Aydin H, 2010, METAB SYNDR RELAT D, V8, P229, DOI 10.1089/met.2009.0080
   Bambace Clara, 2011, Cardiovasc Pathol, V20, pe153, DOI 10.1016/j.carpath.2010.07.005
   Birkenhäger AM, 2007, NETH J MED, V65, P127
   Chen JW, 1998, DIABETES CARE, V21, P1743, DOI 10.2337/diacare.21.10.1743
   Chuang SY, 2006, AM J HYPERTENS, V19, P788, DOI 10.1016/j.amjhyper.2006.01.010
   Cuspidi C, 2004, J HYPERTENS, V22, P273, DOI 10.1097/00004872-200402000-00010
   Cuspidi C, 2008, BLOOD PRESS MONIT, V13, P318, DOI 10.1097/MBP.0b013e32830d4bf8
   DELASIERRA A, 1995, AM J HYPERTENS, V8, P970, DOI 10.1016/0895-7061(95)00225-1
   Della Mea P, 2005, AM J HYPERTENS, V18, P30, DOI 10.1016/j.amjhyper.2004.08.029
   DEVEREUX RB, 1987, HYPERTENSION, V9, P19
   Diamantopoulos EJ, 2006, CLIN EXP HYPERTENS, V28, P625, DOI 10.1080/10641960600946106
   GARRISON RJ, 1987, PREV MED, V16, P235, DOI 10.1016/0091-7435(87)90087-9
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   HENRY WL, 1980, CIRCULATION, V62, P212, DOI 10.1161/01.CIR.62.2.212
   Hojo Y, 1997, J HUM HYPERTENS, V11, P665, DOI 10.1038/sj.jhh.1000515
   Hoshide S, 2003, AM J HYPERTENS, V16, P434, DOI 10.1016/S0895-7061(03)00567-3
   Iacobellis G, 2005, NAT CLIN PRACT CARD, V2, P536, DOI 10.1038/ncpcardio0319
   Iacobellis G, 2003, J CLIN ENDOCR METAB, V88, P5163, DOI 10.1210/jc.2003-030698
   Iacobellis G, 2008, INT J CARDIOL, V128, P424, DOI 10.1016/j.ijcard.2007.12.072
   Ijiri H, 2000, JPN CIRC J, V64, P499, DOI 10.1253/jcj.64.499
   IMAI Y, 1992, CLIN EXP HYPERTENS A, V14, P1141, DOI 10.3109/10641969209038198
   Kotsis V, 2005, HYPERTENSION, V45, P602, DOI 10.1161/01.HYP.0000158261.86674.8e
   Lacobellis G, 2008, HORM METAB RES, V40, P442, DOI 10.1055/s-2008-1062724
   Lurbe E, 2001, J HYPERTENS, V19, P1421, DOI 10.1097/00004872-200108000-00010
   Manzella D, 2001, J CLIN ENDOCR METAB, V86, P2769, DOI 10.1210/jc.86.6.2769
   MARCHINGTON JM, 1989, COMP BIOCHEM PHYS B, V94, P225, DOI 10.1016/0305-0491(89)90337-4
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Nakano S, 2002, CLIN EXP HYPERTENS, V24, P65, DOI 10.1081/CEH-100108716
   O'Brien E, 2003, J HYPERTENS, V21, P821, DOI 10.1097/00004872-200305000-00001
   OBRIEN E, 1988, LANCET, V2, P397
   Palatini P, 2004, J HYPERTENS, V22, pS234, DOI 10.1097/00004872-200406002-00820
   Ragot S, 1999, J HYPERTENS, V17, P1805, DOI 10.1097/00004872-199917121-00004
   Rahman M, 2005, BLOOD PRESS MONIT, V10, P25, DOI 10.1097/00126097-200502000-00006
   Rhéaume C, 2009, HYPERTENSION, V54, P91, DOI 10.1161/HYPERTENSIONAHA.109.131656
   Sironi AM, 2004, HYPERTENSION, V44, P127, DOI 10.1161/01.HYP.0000137982.10191.0a
   Sironi AM, 2008, HYPERTENSION, V51, P282, DOI 10.1161/HYPERTENSIONAHA.107.098640
   Soylu A, 2009, ECHOCARDIOGR-J CARD, V26, P378, DOI 10.1111/j.1540-8175.2008.00821.x
   Tartan Z, 2006, TOHOKU J EXP MED, V210, P57, DOI 10.1620/tjem.210.57
   Teijeira-Fernandez E, 2008, J HUM HYPERTENS, V22, P856, DOI 10.1038/jhh.2008.75
NR 40
TC 34
Z9 39
U1 0
U2 4
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1064-1963
EI 1525-6006
J9 CLIN EXP HYPERTENS
JI Clin. Exp. Hypertens.
PY 2012
VL 34
IS 3
BP 165
EP 170
DI 10.3109/10641963.2011.577488
PG 6
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA 925IF
UT WOS:000302754200002
PM 22008026
DA 2025-06-11
ER

PT J
AU Sestito, A
   Lanza, GA
   Le Pera, D
   De Armas, L
   Sgueglia, GA
   Infusino, F
   Millucci, R
   Tonali, PA
   Crea, F
   Valeriarni, M
AF Sestito, Alfonso
   Lanza, Gaetano Antonio
   Le Pera, Domenica
   De Armas, Liala
   Sgueglia, Gregory Angelo
   Infusino, Fablo
   Millucci, Roberto
   Tonali, Pietro Attillo
   Crea, Filippo
   Valeriarni, Massimillano
TI Spinal cord stimulation normalizes abnormal cortical pain processing in
   patients with cardiac syndrome X
SO PAIN
LA English
DT Article
DE Spinal cord stimulation; Angina pectoris; Laser evoked potential
ID NOXIOUS INHIBITORY CONTROLS; NORMAL CORONARY ARTERIOGRAMS; REFRACTORY
   ANGINA-PECTORIS; LASER-EVOKED POTENTIALS; CHEST-PAIN; CONVERGENT
   NEURONS; BRAIN; MECHANISMS; ARTERIES; STRESS
AB Cardiac syndrome X (CSX) is characterized by effort angina, ST-segment depression during stress tests and normal corollary arteries. Abnormal nociception was suggested in these patients by Studies showing a reduced cardiac pain threshold: furthermore. we recently found a lack of habituation to pain stimuli using recording of laser evoked potentials (LEPs). In CSX patients with severe angina. spinal cord stimulation (SCS) was shown to improve symptoms. In this study we investigated whether, in these patients, SCS has any effects oil the excitability of the nociceptive system. assessed by LEPs recording. We studied 16 CSX patients (61.6 +/- 7 years: 4 men) who underwent SCS for refractory angina. Cortical LEPs were recorded during stimulation of the chest and right-hand during active SCS (SCS-ON) and in the absence of SCS (SCS-OFF). using a randomized cross-over design. Three sequences of painful stimuli were applied at each site during each test. During the first sequence of chest stimuli, the N2/P2 LEP amplitude was higher during the SCS-ON, compared to the SCS-OFF phase ( 18.2 +/- 7.8 vs. 11.5 +/- 4.4 mu V, P = 0.006). The N2/ 112 amplitude did not change significantly across the three stimulation sequences during the SCS-OFF phase (P = 0.22). whereas it decreased progressively during the second and third sequence (to 87.1 +/- 29.5% and 76.4 +/- 24.1%, respectively) compared with the first sequence. during the SCS-ON phase (P = 0.014). Similar results were observed during right-hand stimulation. Our study shows that in CSX patients SCS is able to restore habituation to peripheral pain stimuli. This effect might contribute to restore the ability of CSX patients to better tolerate cardiac pain. (C) 2008 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
C1 [Sestito, Alfonso; Lanza, Gaetano Antonio; Sgueglia, Gregory Angelo; Infusino, Fablo; Crea, Filippo] Univ Cattolica Sacro Cuore, Ist Cardiol, I-00168 Rome, Italy.
   [Le Pera, Domenica; De Armas, Liala] IRCSS San Raffaele, Rome, Italy.
   [Millucci, Roberto; Valeriarni, Massimillano] IRCCS, Osped Pediat Bambino Gesu, Div Neurol, Rome, Italy.
   [Tonali, Pietro Attillo] Univ Cattolica Sacro Cuore, Ist Neurol, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   IRCCS Bambino Gesu; Catholic University of the Sacred Heart; IRCCS
   Policlinico Gemelli
RP Lanza, GA (corresponding author), Univ Cattolica Sacro Cuore, Ist Cardiol, Largo A Gemelli 8, I-00168 Rome, Italy.
EM g.a.lanza@inwind.it
RI Lanza, Gaetano/AAC-2660-2019; Valeriani, Massimiliano/AAA-4459-2020;
   Crea, Filippo/AAC-9754-2022; Infusino, Fabio/JEF-6750-2023; Sgueglia,
   Gregory/A-9701-2019; Valeriani, Massimiliano/K-5736-2016
OI Infusino, Fabio/0000-0001-9287-5936; Sgueglia,
   Gregory/0000-0001-9680-7412; Valeriani, Massimiliano/0000-0001-6602-103X
CR [Anonymous], ISCHEMIC HEART DIS
   Arendt-Nielsen L, 2000, Prog Brain Res, V129, P343
   ARENDTNIELSEN L, 1988, J NEUROL NEUROSUR PS, V51, P35, DOI 10.1136/jnnp.51.1.35
   Bentley DE, 2002, CLIN NEUROPHYSIOL, V113, P1351, DOI 10.1016/S1388-2457(02)00149-9
   CAMICI PG, 1991, J AM COLL CARDIOL, V17, P1461, DOI 10.1016/0735-1097(91)90632-J
   CANNON RO, 1990, J AM COLL CARDIOL, V16, P1359, DOI 10.1016/0735-1097(90)90377-2
   CANNON RO, 1983, J AM COLL CARDIOL, V1, P1359, DOI 10.1016/S0735-1097(83)80037-0
   CHANDLER MJ, 1993, EUR HEART J, V14, P96, DOI 10.1093/eurheartj/14.1.96
   CHAUHAN A, 1994, CIRCULATION, V89, P694, DOI 10.1161/01.CIR.89.2.694
   ELIASSON T, 1993, CORONARY ARTERY DIS, V4, P819
   Ellrich J, 1998, BRAIN RES, V803, P161, DOI 10.1016/S0006-8993(98)00646-5
   FIELDS HL, 1988, PAIN, V33, P195, DOI 10.1016/0304-3959(88)90091-7
   Foreman RD, 1999, ANNU REV PHYSIOL, V61, P143, DOI 10.1146/annurev.physiol.61.1.143
   FOREMAN RD, 1986, PROG BRAIN RES, V67, P227
   Foreman RD, 2000, CARDIOVASC RES, V47, P367, DOI 10.1016/S0008-6363(00)00095-X
   Frot M, 2003, BRAIN, V126, P438, DOI 10.1093/brain/awg032
   Frot M, 1999, CLIN NEUROPHYSIOL, V110, P133, DOI 10.1016/S0168-5597(98)00054-9
   Garcia-Larrea L, 2003, NEUROPHYSIOL CLIN, V33, P279, DOI 10.1016/j.neucli.2003.10.008
   GOODIN D, 1994, ELECTROEN CLIN NEURO, V91, P18, DOI 10.1016/0013-4694(94)90014-0
   JANNE P, 1987, EUR HEART J, V8, P125, DOI 10.1093/eurheartj/8.suppl_G.125
   Jessurun G, 2003, EUR J PAIN, V7, P507, DOI 10.1016/S1090-3801(03)00022-3
   Klem G H, 1999, Electroencephalogr Clin Neurophysiol Suppl, V52, P3
   KUNDE V, 1993, ELECTROEN CLIN NEURO, V88, P280, DOI 10.1016/0168-5597(93)90052-Q
   LAGERQVIST B, 1992, BRIT HEART J, V68, P282
   Lanza GA, 2007, HEART, V93, P159, DOI 10.1136/hrt.2005.067330
   Lanza GA, 2005, EUR HEART J, V26, P983, DOI 10.1093/eurheartj/ehi089
   Lanza GA, 2002, HEART, V88, P328, DOI 10.1136/heart.88.4.328
   LEBARS D, 1979, PAIN, V6, P305, DOI 10.1016/0304-3959(79)90050-2
   LEBARS D, 1979, PAIN, V6, P283, DOI 10.1016/0304-3959(79)90049-6
   Lenz FA, 1998, J NEUROPHYSIOL, V79, P2231, DOI 10.1152/jn.1998.79.4.2231
   Mancia G, 2007, J HYPERTENS, V25, P1751, DOI 10.1097/HJH.0b013e3282f0580f
   MELZACK R, 1965, SCIENCE, V150, P971, DOI 10.1126/science.150.3699.971
   NIHOYANNOPOULOS P, 1991, J AM COLL CARDIOL, V18, P1463, DOI 10.1016/0735-1097(91)90676-Z
   Ohara S, 2006, PAIN, V123, P244, DOI 10.1016/j.pain.2006.02.012
   OPHERK D, 1981, CIRCULATION, V63, P817, DOI 10.1161/01.CIR.63.4.817
   Pasceri V, 1998, J AM COLL CARDIOL, V31, P62, DOI 10.1016/S0735-1097(97)00421-X
   Sgueglia GA, 2007, HEART, V93, P591, DOI 10.1136/hrt.2006.102194
   SHAPIRO LM, 1988, BRIT MED J, V296, P170, DOI 10.1136/bmj.296.6616.170-a
   TenVaarwerk IAM, 1999, HEART, V82, P82, DOI 10.1136/hrt.82.1.82
   Treede RD, 2003, NEUROPHYSIOL CLIN, V33, P303, DOI 10.1016/j.neucli.2003.10.009
   Valeriani M, 2000, CLIN NEUROPHYSIOL, V111, P1103, DOI 10.1016/S1388-2457(00)00273-X
   Valeriani M, 2005, EUR HEART J, V26, P975, DOI 10.1093/eurheartj/ehi229
   Valeriani M, 2003, PAIN, V105, P57, DOI 10.1016/S0304-3959(03)00137-4
   VILLANUEVA L, 1984, BRAIN RES, V321, P165, DOI 10.1016/0006-8993(84)90695-4
   Weiss T, 1997, NEUROSCI LETT, V227, P95, DOI 10.1016/S0304-3940(97)00320-0
NR 45
TC 25
Z9 29
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0304-3959
EI 1872-6623
J9 PAIN
JI Pain
PD SEP 30
PY 2008
VL 139
IS 1
BP 82
EP 89
DI 10.1016/j.pain.2008.03.015
PG 8
WC Anesthesiology; Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; Neurosciences & Neurology
GA 361WV
UT WOS:000260159200010
PM 18440702
DA 2025-06-11
ER

PT J
AU Spitzer, C
   Weihs, A
   Ewert, R
   Stubbe, B
   Penzel, T
   Fietze, I
   Völzke, H
   Grabe, HJ
AF Spitzer, Carsten
   Weihs, Antoine
   Ewert, Ralf
   Stubbe, Beate
   Penzel, Thomas
   Fietze, Ingo
   Voelzke, Henry
   Grabe, Hans J.
TI Childhood maltreatment and sleep apnea: Findings from a cross-sectional
   general population study
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Childhood maltreatment; Sleep disturbances; Sleep apnea; Polysomnography
   (PSG); Apnea-hypopnea index (AHI); Oxygen desaturation index (ODI);
   General population
ID EYE-MOVEMENT SLEEP; SEXUAL-ABUSE; HEALTH; EXPERIENCES; TRAUMA; INSOMNIA;
   METAANALYSIS; PREVALENCE; VERSION; BIAS
AB Objective: Cumulative evidence indicates that childhood maltreatment (CM) is associated with sleep disturbances possibly suggesting sleep apnea. However, the relation between CM and objective measures of sleep apnea as determined by polysomnography (PSG) has not yet been assessed. Methods: Using a cross-sectional design and based on PSG measurements from N = 962 subjects from the SHIPTrend general population study, we used linear regression models to investigate the relationship between apneahypopnea (AHI) and oxygen desaturation index (ODI) and Epworth sleepiness scale (ESS) metrics and the Childhood Trauma Questionnaire (CTQ). All significant models were additionally adjusted for obesity, depression, metabolic syndrome, risky health behaviors, and socioeconomic factors. Results: While both AHI and ESS were positively associated with the CTQ sum score, ODI was not. Investigating the CTQ subscales, ESS was associated with emotional abuse and emotional neglect; AHI was associated with physical and sexual abuse as well as physical neglect. For both the sum score and the subscales of the CTQ, ESS effects were partially mediated by depressive symptoms, while AHI effects were mediated by obesity, risky health behaviors, and metabolic syndrome. Conclusion: The findings of this general population study suggest an association between CM, particularly physical neglect, and objective as well as subjective indicators of sleep apnea, which were partially mediated by depressive symptoms and obesity.
C1 [Spitzer, Carsten] Univ Med Rostock, Dept Psychosomat Med & Psychotherapy, Rostock, Germany.
   [Weihs, Antoine; Grabe, Hans J.] Univ Med Greifswald, Dept Psychiat & Psychotherapy, Greifswald, Germany.
   [Ewert, Ralf; Stubbe, Beate] Univ Med Greifswald, Dept Internal Med Cardiol B, Pulm Med Infect Dis & Intens Care, Greifswald, Germany.
   [Penzel, Thomas; Fietze, Ingo] Univ Hosp Charite Berlin, Ctr Sleep Med, Berlin, Germany.
   [Voelzke, Henry] Univ Greifswald, Dept Community Med, SHIP Clin Epidemiol Res, Greifswald, Germany.
   [Voelzke, Henry] German Ctr Diabet Res DZD, Partner Site Greifswald, Greifswald, Germany.
   [Voelzke, Henry] German Ctr Cardiovasc Res DZHK, Site Greifswald, Greifswald, Germany.
   [Grabe, Hans J.] German Ctr Neurodegenerat Dis DZNE, Site Rostock Greifswald, Greifswald, Germany.
   [Spitzer, Carsten] Univ Med Rostock, Dept Psychosomat Med & Psychotherapy, Gehlsheimer Str 20, D-18147 Rostock, Germany.
C3 University of Rostock; Universitat Greifswald; Greifswald Medical
   School; Universitat Greifswald; Greifswald Medical School; Berlin
   Institute of Health; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin; Universitat Greifswald;
   German Center for Diabetes Research (DZD); German Centre for
   Cardiovascular Research; Helmholtz Association; German Center for
   Neurodegenerative Diseases (DZNE); University of Rostock
RP Spitzer, C (corresponding author), Univ Med Rostock, Dept Psychosomat Med & Psychotherapy, Gehlsheimer Str 20, D-18147 Rostock, Germany.
EM carsten.spitzer@med.uni-rostock.de
RI ; Penzel, Thomas/M-2344-2014
OI Fietze, Ingo/0000-0001-5567-5206; Weihs, Antoine/0000-0002-7113-0027;
   Penzel, Thomas/0000-0002-4304-0112
FU German Federal State of Mecklenburg-West Pomerania; Siemens
   Healthineers, Erlangen, Germany; Federal State of Mecklenburg-West
   Pomerania; German RLS organization (Deutsche Restless Legs Vereinigung);
   EU Joint Programme-Neurodegenerative Disease Research [01ED1615];
   National Institutes of Health (NIH) [AG059421]; Deutsche
   Forschungsgemeinschaft (DFG) [GR1912/13-1, GR1912/13-2]
FX The Study of Health in Pomerania (SHIP) is part of the Community
   Medicine Research net (CMR) (http:// www.medizin.uni-greifswald. de/icm)
   of the University Medicine Greifswald, which is supported by the German
   Federal State of Mecklenburg-West Pomerania. MRI scans in SHIP-Trend
   have been supported by a joint grant from Siemens Healthineers,
   Erlangen, Germany, and the Federal State of Mecklenburg-West Pomerania.
   PSG assessment was in part supported by the German RLS organization
   (Deutsche Restless Legs Vereinigung) . This study was further supported
   by EU Joint Programme-Neurodegenerative Disease Research funding for
   BRIDGET [grant number 01ED1615] , the National Institutes of Health
   (NIH) [grant number AG059421] and the Deutsche Forschungsgemeinschaft
   (DFG) [GR1912/13-1 and GR1912/13-2] .
CR Bader K, 2007, J SLEEP RES, V16, P285, DOI 10.1111/j.1365-2869.2007.00608.x
   Bader K, 2013, J CLIN NEUROPHYSIOL, V30, P188, DOI 10.1097/WNP.0b013e3182767c4a
   Baumeister SE, 2005, GESUNDHEITSWESEN, V67, P39, DOI 10.1055/s-2004-813829
   Bellis MA, 2019, LANCET PUBLIC HEALTH, V4, pE517, DOI 10.1016/S2468-2667(19)30145-8
   Benjafield AV, 2019, LANCET RESP MED, V7, P687, DOI 10.1016/S2213-2600(19)30198-5
   Bernstein DP, 2003, CHILD ABUSE NEGLECT, V27, P169, DOI 10.1016/S0145-2134(02)00541-0
   Briggs EC, 2021, AM PSYCHOL, V76, P243, DOI 10.1037/amp0000768
   Brindle RC, 2018, PSYCHOSOM MED, V80, P200, DOI 10.1097/PSY.0000000000000542
   Carroll HA, 2020, PSYCHIAT RES, V291, DOI 10.1016/j.psychres.2020.113236
   Cecil CAM, 2017, CHILD ABUSE NEGLECT, V63, P106, DOI 10.1016/j.chiabu.2016.11.024
   Chang JL, 2023, INT FORUM ALLERGY RH, V13, P1061, DOI 10.1002/alr.23079
   Danese A, 2014, MOL PSYCHIATR, V19, P544, DOI 10.1038/mp.2013.54
   Ernst G, 2016, SLEEP BREATH, V20, P1175, DOI 10.1007/s11325-016-1330-3
   Fietze I, 2019, J SLEEP RES, V28, DOI 10.1111/jsr.12770
   Fujiwara T, 2022, PSYCHIAT CLIN NEUROS, V76, P544, DOI 10.1111/pcn.13464
   Garbarino S, 2020, BEHAV SLEEP MED, V18, P35, DOI 10.1080/15402002.2018.1545649
   Georgieva S, 2021, CHILD ABUSE NEGLECT, V120, DOI 10.1016/j.chiabu.2021.105223
   Guglielmi O, 2019, SLEEP MED, V57, P100, DOI 10.1016/j.sleep.2019.01.042
   Hardt J, 2010, PSYCHOL REP, V107, P425, DOI 10.2466/02.04.09.10.16.21.PR0.107.5.425-440
   Harrell FE, 2015, SPRINGER SER STAT, DOI 10.1007/978-3-319-19425-7
   Heany SJ, 2018, DEV PSYCHOPATHOL, V30, P1475, DOI 10.1017/S0954579417001717
   Heitkemper MM, 2011, BIOL RES NURS, V13, P399, DOI 10.1177/1099800410393274
   Higgs E, 2020, CHILD ABUSE NEGLECT, V107, DOI 10.1016/j.chiabu.2020.104567
   Holz NE, 2023, BIOL PSYCHIAT, V93, P430, DOI 10.1016/j.biopsych.2022.10.019
   Hughes K, 2017, LANCET PUBLIC HEALTH, V2, pE356, DOI 10.1016/S2468-2667(17)30118-4
   Iber C., 2007, AASM MANUAL SCORING, V1
   Insana SP, 2012, BIOL PSYCHOL, V89, P570, DOI 10.1016/j.biopsycho.2012.01.001
   JOHNS MW, 1991, SLEEP, V14, P540, DOI 10.1093/sleep/14.6.540
   Kajeepeta S, 2015, SLEEP MED, V16, P320, DOI 10.1016/j.sleep.2014.12.013
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Laskemoen JF, 2021, PSYCHOL MED, V51, P2337, DOI 10.1017/S0033291720000914
   Lee JEJ, 2021, LUNG, V199, P87, DOI 10.1007/s00408-021-00426-w
   Li MZ, 2023, TRAUMA VIOLENCE ABUS, V24, P2560, DOI 10.1177/15248380221102558
   Lim L, 2020, NEUROSCI BIOBEHAV R, V116, P406, DOI 10.1016/j.neubiorev.2020.07.004
   Lind MJ, 2016, PSYCHOL TRAUMA-US, V8, P198, DOI 10.1037/tra0000080
   Madigan S, 2023, WORLD PSYCHIATRY, V22, P463, DOI 10.1002/wps.21122
   Malicki M, 2023, METABOLITES, V13, DOI 10.3390/metabo13010060
   Matsumoto M, 2023, TRAUMA VIOLENCE ABUS, V24, P487, DOI 10.1177/15248380211030502
   McWhorter KL, 2019, SLEEP, V42, DOI 10.1093/sleep/zsz108
   Nielsen T, 2019, SLEEP MED, V56, P57, DOI 10.1016/j.sleep.2019.03.004
   Ooi EL, 2023, CURR PROB CARDIOLOGY, V48, DOI 10.1016/j.cpcardiol.2022.101178
   Parnes MF, 2022, CHILD ABUSE NEGLECT, V127, DOI 10.1016/j.chiabu.2022.105562
   R Core Team, 2019, R LANG ENV STAT COMP
   Rashid NHA, 2021, LARYNGOSCOPE, V131, P440, DOI 10.1002/lary.28663
   Scott KM, 2012, BRIT J PSYCHIAT, V200, P469, DOI 10.1192/bjp.bp.111.103267
   Steine IM, 2019, CHILD ABUSE NEGLECT, V93, P263, DOI 10.1016/j.chiabu.2019.05.009
   Stekhoven DJ, 2012, BIOINFORMATICS, V28, P112, DOI 10.1093/bioinformatics/btr597
   Stubbe B., 2016, journal of sleep disorders and management, V2, DOI [10.23937/2572-4053.1510010, DOI 10.23937/2572-4053.1510010]
   Sullivan K, 2019, SLEEP, V42, DOI 10.1093/sleep/zsz087
   Taylor DJ, 2016, SLEEP, V39, P1795, DOI 10.5665/sleep.6156
   Van den Bergh O, 2016, CURR OPIN PSYCHIATR, V29, P302, DOI 10.1097/YCO.0000000000000267
   Völzke H, 2011, INT J EPIDEMIOL, V40, P294, DOI 10.1093/ije/dyp394
   Völzke H, 2022, INT J EPIDEMIOL, V51, pE372, DOI 10.1093/ije/dyac034
   von Elm E, 2007, LANCET, V370, P1453, DOI 10.1016/S0140-6736(07)61602-X
   Walentynowicz M, 2017, BRIT J HEALTH PSYCH, V22, P362, DOI 10.1111/bjhp.12234
   Wang C, 2022, J DIABETES INVEST, V13, P1396, DOI 10.1111/jdi.13793
   Weihs A, 2021, SLEEP, V44, DOI 10.1093/sleep/zsaa204
   Whitehead BR, 2013, PSYCHOL HEALTH, V28, P784, DOI 10.1080/08870446.2012.759224
   Wingenfeld K, 2010, PSYCHOTHER PSYCH MED, V60, P442, DOI 10.1055/s-0030-1247564
   Yu HJ, 2022, SLEEP MED, V98, P26, DOI 10.1016/j.sleep.2022.06.006
   Zacharias HU, 2021, JAMA NETW OPEN, V4, DOI 10.1001/jamanetworkopen.2021.28225
   Zhu SY, 2022, J GLOB HEALTH, V12, DOI 10.7189/jogh.12.04082
NR 62
TC 0
Z9 0
U1 1
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD MAR
PY 2024
VL 178
AR 111600
DI 10.1016/j.jpsychores.2024.111600
EA FEB 2024
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA KZ2E7
UT WOS:001183718100001
PM 38340571
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Jan, A
   Shah, M
   Shah, SA
   Habib, SH
   Ehtesham, E
   Ahmed, N
AF Jan, Amin
   Shah, Mohsin
   Shah, Shahid Ali
   Habib, Syed Hamid
   Ehtesham, Ehtesham
   Ahmed, Naseer
TI Melatonin rescues pregnant female mice and their juvenile offspring from
   high fat diet-induced alzheimer disease neuropathy
SO HELIYON
LA English
DT Article
DE HFD; Obesity; Neuroinflammation; Neurodegeneration; Melatonin treatment;
   Synaptic dysfunction; ROS; Oxidative stress; SIRT1/Nrf2
ID BRAIN INSULIN-RESISTANCE; METABOLIC SYNDROME; INFLAMMATION; DYSFUNCTION;
   IMPAIRMENT; INDUCTION; COGNITION; BEHAVIOR; OBESITY; IMPACT
AB High fat diet (HFD) is a prime factor, which contributes to the present epidemic of metabolic syndrome. Prolonged intake of HFD induces oxidative stress (OS) that in turn causes neuroinflammation, neurodegeneration, insulin resistance, amyloid burden, synaptic dysfunction and cognitive impairment hence leading to Alzheimer's disease neuropathy. Melatonin (secreted by the Pineal gland) has the potential to nullify the toxic effects of reactive oxygen species (ROS) and have been shown to ameliorate various complications induced by HFD in rodent models. This study aimed to assess the neurotherapeutic effects of melatonin on HFD-induced neuroinflammation and neurodegeneration mediated by OS in pregnant female mice and their offspring. Western blotting, immunohistochemistry and antioxidant enzyme assays were used for quantification of samples from the hippocampal region of the brain of pregnant albino mice and their offspring. Short- and long-term memory was assessed by Y-maze and Morris Water Maze tests. HFD significantly induced OS leading to AD like neuropathology in the pregnant mice and their offspring while melatonin administration simultaneously with the HFD significantly prevented this neuropathy. This study reports that melatonin exerts these effects through the stimulation of SIRT1/Nrf2/HO-1 pathway that in turn reduces the HFD-induced OS and its downstream signaling. In conclusion melatonin prevents HFD-induced multiple complications that ultimately leads to the memory dysfunction in pregnant female mice and their successive generation via activation of SIRT1/Nrf2 signaling pathway.
C1 [Jan, Amin; Shah, Mohsin; Habib, Syed Hamid; Ehtesham, Ehtesham; Ahmed, Naseer] Khyber Med Univ, Inst Basic Med Sci, Peshawar, Pakistan.
   [Shah, Shahid Ali] Haripur Univ, Dept Biochem, Haripur, Pakistan.
C3 Khyber Medical University
RP Shah, M (corresponding author), Khyber Med Univ, Inst Basic Med Sci, Dept Physiol, Peshawar, Pakistan.
EM mohsin.ibms@kmu.edu.pk
RI Habib, Syed/ITU-1299-2023
FU Organization of Research Innovation and commercialization of Khyber
   Medical University; Khyber Medical University [DIR/ORIC/REF/22/00003]
FX This research was supported by Organization of Research Innovation and
   commercialization of Khyber Medical University and the publication
   charges for this article are partially borne from Khyber Medical
   University publication fund (reference No. DIR/ORIC/REF/22/00003) .
CR Ahmed T, 2014, NEUROBIOL AGING, V35, P2474, DOI 10.1016/j.neurobiolaging.2014.05.005
   Ali T, 2020, FRONT MOL NEUROSCI, V13, DOI 10.3389/fnmol.2020.00096
   Almeida-Suhett CP, 2017, PHYSIOL BEHAV, V169, P130, DOI 10.1016/j.physbeh.2016.11.016
   Alzoubi KH, 2018, BEHAV BRAIN RES, V336, P93, DOI 10.1016/j.bbr.2017.08.047
   Alzoubi KH, 2013, PHYSIOL BEHAV, V119, P72, DOI 10.1016/j.physbeh.2013.06.011
   Amin KA, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-74
   Araki W, 2016, BRAIN RES BULL, V126, P170, DOI 10.1016/j.brainresbull.2016.04.009
   Arnold SE, 2014, NEUROBIOL DIS, V67, P79, DOI 10.1016/j.nbd.2014.03.011
   Arshad NA, 2018, CNS NEUROL DISORD-DR, V17, P595, DOI 10.2174/1871527317666180724143258
   Bak J, 2017, BEHAV BRAIN RES, V320, P219, DOI 10.1016/j.bbr.2016.12.011
   Balakumar M, 2016, MOL CELL BIOCHEM, V423, P93, DOI 10.1007/s11010-016-2828-5
   Bosiacki M, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20174108
   Busquets O, 2017, MECH AGEING DEV, V162, P38, DOI 10.1016/j.mad.2016.11.002
   Chi H, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19103082
   Chrustek A, 2021, ACTA PHARMACEUT, V71, P335, DOI 10.2478/acph-2021-0027
   CONNOLLY JA, 1977, P NATL ACAD SCI USA, V74, P2437, DOI 10.1073/pnas.74.6.2437
   Boleti APD, 2020, NEUROCHEM INT, V136, DOI 10.1016/j.neuint.2020.104714
   Denver P, 2018, DIABETES OBES METAB, V20, P1166, DOI 10.1111/dom.13210
   Favero G, 2017, INT J ENDOCRINOL, V2017, DOI 10.1155/2017/1835195
   Grundy SM, 2016, TRENDS CARDIOVAS MED, V26, P364, DOI 10.1016/j.tcm.2015.10.004
   Han TK, 2019, BRAIN RES, V1707, P154, DOI 10.1016/j.brainres.2018.11.035
   Hardeland R, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20051223
   He T, 2023, J MOL MED, V101, P1397, DOI 10.1007/s00109-023-02364-x
   Kang EB, 2016, J NEUROENDOCRINOL, V28, DOI 10.1111/jne.12385
   Kang TC, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9070617
   Karaaslan C, 2015, CURR TOP MED CHEM, V15, P894, DOI 10.2174/1568026615666150220120946
   Kesh SB., 2016, Asian Journal of Pharmaceutical and Clinical Research, V9, P47
   Kim JM, 2017, J AGR FOOD CHEM, V65, P2719, DOI 10.1021/acs.jafc.7b00297
   Kohjima M, 2010, ENDOCRINOLOGY, V151, P1532, DOI 10.1210/en.2009-1196
   Kohlgruber A, 2015, CURR DIABETES REP, V15, DOI 10.1007/s11892-015-0670-x
   Kölliker-Frers R, 2021, MEDIAT INFLAMM, V2021, DOI 10.1155/2021/9999146
   Kothari V, 2017, BBA-MOL BASIS DIS, V1863, P499, DOI 10.1016/j.bbadis.2016.10.006
   Li SM, 2020, J NEUROCHEM, V154, pCP5, DOI 10.1111/jnc.15007
   Lian CY, 2020, CHEM-BIOL INTERACT, V330, DOI 10.1016/j.cbi.2020.109199
   Lin BW, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.115.003154
   Liu ZJ, 2018, J PINEAL RES, V64, DOI 10.1111/jpi.12455
   Mazzei G, 2021, AGING CELL, V20, DOI 10.1111/acel.13429
   McNeilly AD, 2015, PSYCHONEUROENDOCRINO, V52, P272, DOI 10.1016/j.psyneuen.2014.12.002
   de Farias TDM, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00750
   Mihardja M, 2020, ANN NY ACAD SCI, V1478, P43, DOI 10.1111/nyas.14436
   Mishra M, 2017, EXPERT REV PROTEOMIC, V14, P1037, DOI 10.1080/14789450.2017.1388167
   Misra A, 2010, J AM COLL NUTR, V29, p289S, DOI 10.1080/07315724.2010.10719844
   Muth AK, 2021, CLIN NUTR, V40, P3999, DOI 10.1016/j.clnu.2021.04.043
   Nawaz A, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-29773-0
   Owino S, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00488
   Pasinetti GM, 2008, J NEUROCHEM, V106, P1503, DOI 10.1111/j.1471-4159.2008.05454.x
   Prestipino L., 2020, PhD Thesis
   Proctor DT, 2011, PROG NEUROBIOL, V93, P509, DOI 10.1016/j.pneurobio.2011.02.002
   Profenno LA, 2010, BIOL PSYCHIAT, V67, P505, DOI 10.1016/j.biopsych.2009.02.013
   Pyrillou K, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.613170
   Rad SK, 2018, DRUG DES DEV THER, V12, P3999, DOI 10.2147/DDDT.S173970
   Raygan F, 2019, CLIN NUTR, V38, P191, DOI 10.1016/j.clnu.2017.12.004
   Reiter RJ, 2014, HUM REPROD UPDATE, V20, P293, DOI 10.1093/humupd/dmt054
   Rius-Pérez S, 2020, ANTIOXID REDOX SIGN, V33, P145, DOI 10.1089/ars.2019.7975
   Shah SA, 2017, CNS NEUROSCI THER, V23, P33, DOI 10.1111/cns.12588
   Singh S, 2020, CURR NEUROPHARMACOL, V18, P918, DOI 10.2174/1570159X18666200207120949
   Singh V, 2020, INFLAMMATION, V43, P1589, DOI 10.1007/s10753-020-01242-9
   Takahashi M, 1999, J NUTR SCI VITAMINOL, V45, P583, DOI 10.3177/jnsv.45.583
   Targhazeh N, 2022, BIOCHIMIE, V202, P34, DOI 10.1016/j.biochi.2022.06.008
   Taylor ZB, 2021, NEUROSCI BIOBEHAV R, V130, P91, DOI 10.1016/j.neubiorev.2021.08.008
   Thakur P, 2018, J DRUG TARGET, V26, P766, DOI 10.1080/1061186X.2017.1419478
   Uranga RM, 2010, J NEUROCHEM, V114, P344, DOI 10.1111/j.1471-4159.2010.06803.x
   Varatharaj A, 2017, BRAIN BEHAV IMMUN, V60, P1, DOI 10.1016/j.bbi.2016.03.010
   Vorhees CV, 2006, NAT PROTOC, V1, P848, DOI 10.1038/nprot.2006.116
   Wang S, 2016, J NUTR BIOCHEM, V36, P42, DOI 10.1016/j.jnutbio.2016.07.008
   Xiong J, 2022, METAB BRAIN DIS, V37, P1941, DOI 10.1007/s11011-022-01029-x
   Yu TT, 2016, MINI-REV MED CHEM, V16, P1230, DOI 10.2174/1389557516666160505115743
   Zhao W, 2019, WORLD NEUROSURG, V127, pE346, DOI 10.1016/j.wneu.2019.03.116
NR 68
TC 1
Z9 1
U1 0
U2 0
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD SEP 15
PY 2024
VL 10
IS 17
AR e36921
DI 10.1016/j.heliyon.2024.e36921
EA AUG 2024
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA E3B6I
UT WOS:001301789300001
PM 39281480
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Feillet-Coudray, C
   Fouret, G
   Casas, F
   Coudray, C
AF Feillet-Coudray, Christine
   Fouret, Gilles
   Casas, Francois
   Coudray, Charles
TI Impact of high dietary lipid intake and related metabolic disorders on
   the abundance and acyl composition of the unique mitochondrial
   phospholipid, cardiolipin
SO JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
LA English
DT Review
DE Cardiolipin; Fatty acid; High fat diet; Metabolic syndrome;
   Mitochondria; Obesity; Oxidative stress; Steatosis
ID FATTY-ACID-COMPOSITION; RAT-LIVER MITOCHONDRIA; INDUCED DIABETIC-RATS;
   OXIDATIVE STRESS; SKELETAL-MUSCLE; SHOTGUN LIPIDOMICS; RAPESEED OIL;
   COMPLEX-I; FISH-OIL; HEART
AB Excessive dietary lipid intake, coupled with lack of exercise, are the major causes of the development and progression of metabolic syndrome features e. g. obesity, hepatic steatosis, insulin resistance, type 2 diabetes and cardiovascular diseases. These metabolic diseases are associated with both structural and functional alterations of mitochondria. Cardiolipin (CL) is a unique phospholipid that is almost exclusively localized in the mitochondrial inner membrane. Cardiolipin is at the heart of mitochondrial metabolism playing a key role in several processes of mitochondrial bioenergetics as well as in mitochondrial membrane stability and dynamics, and in many of the mitochondrial-dependent steps of apoptosis. Indeed, alterations to CL content and acyl chain profile have been associated with mitochondrial dysfunction in multiple tissues in Barth syndrome and in many other physio-pathological conditions. After a brief overview of the biological roles of CL, we highlight the consequences of lipid overload-related nutritional manipulations as well as related metabolic disorders on both CL content and its fatty acid composition in the major metabolic tissues, the heart, muscle and liver. The goal of this review is to fill a void in the CL literature concerning the effects of CL abundance and form that arise following high lipid supplementation and the related metabolic disorders.
C1 [Feillet-Coudray, Christine; Fouret, Gilles; Casas, Francois; Coudray, Charles] Ctr INRA Montpellier, UMR Dynam Musculaire & Metab 866, F-34060 Montpellier, France.
C3 Universite de Montpellier; INRAE
RP Feillet-Coudray, C (corresponding author), Ctr INRA Montpellier, UMR Dynam Musculaire & Metab 866, F-34060 Montpellier, France.
EM cfeillet@supagro.inra.fr
RI COUDRAY, Charles/AGG-4757-2022
OI Coudray, Charles/0000-0003-2680-7796; Francois,
   Casas/0000-0002-5535-8195
CR Acin-Pérez R, 2008, MOL CELL, V32, P529, DOI 10.1016/j.molcel.2008.10.021
   Ahmed KA, 2012, BIOCHEM J, V441, P719, DOI 10.1042/BJ20111130
   Aoun M, 2012, J BIOENERG BIOMEMBR, V44, P439, DOI 10.1007/s10863-012-9448-x
   Aoun M, 2012, BRIT J NUTR, V107, P647, DOI 10.1017/S000711451100331X
   Baile MG, 2014, J BIOL CHEM, V289, P1768, DOI 10.1074/jbc.M113.525733
   Berg K, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0090964
   BLOMSTRAND R, 1975, ACTA MED SCAND, P51
   Chicco AJ, 2008, HYPERTENSION, V52, P549, DOI 10.1161/HYPERTENSIONAHA.108.114264
   Chicco AJ, 2007, AM J PHYSIOL-CELL PH, V292, pC33, DOI 10.1152/ajpcell.00243.2006
   Claypool SM, 2009, BBA-BIOMEMBRANES, V1788, P2059, DOI 10.1016/j.bbamem.2009.04.020
   Croston TL, 2013, LIFE SCI, V93, P313, DOI 10.1016/j.lfs.2013.07.005
   Dabkowski ER, 2009, AM J PHYSIOL-HEART C, V296, pH359, DOI 10.1152/ajpheart.00467.2008
   Dorn GW, 2010, CIRC RES, V107, P689, DOI 10.1161/CIRCRESAHA.110.225714
   Dulloo AG, 2012, OBES REV, V13, P1, DOI 10.1111/j.1467-789X.2012.01032.x
   EBLE KS, 1990, J BIOL CHEM, V265, P19434
   Feillet-Coudray C, 2013, BRIT J NUTR, V110, P1789, DOI 10.1017/S0007114513001311
   Ferreira FM, 2003, BBA-MOL BASIS DIS, V1639, P113, DOI 10.1016/j.bbadis.2003.08.001
   Ferreira R, 2013, MITOCHONDRION, V13, P762, DOI 10.1016/j.mito.2013.05.001
   Giudetti AM, 2003, J LIPID RES, V44, P2135, DOI 10.1194/jlr.M300237-JLR200
   Gohil VM, 2005, ANAL BIOCHEM, V343, P350, DOI 10.1016/j.ab.2005.04.039
   GUDBJARNASON S, 1987, J MOL CELL CARDIOL, V19, P1141, DOI 10.1016/S0022-2828(87)80357-7
   Haiens TH, 2002, FEBS LETT, V528, P35, DOI 10.1016/S0014-5793(02)03292-1
   Han XL, 2007, BIOCHEMISTRY-US, V46, P6417, DOI 10.1021/bi7004015
   Han XL, 2005, BIOCHEMISTRY-US, V44, P16684, DOI 10.1021/bi051908a
   HATCH GM, 1995, BIOCHEM J, V306, P759, DOI 10.1042/bj3060759
   HATEFI Y, 1985, ANNU REV BIOCHEM, V54, P1015, DOI 10.1146/annurev.biochem.54.1.1015
   He Q, 2014, CHEM PHYS LIPIDS, V179, P75, DOI 10.1016/j.chemphyslip.2013.10.007
   HOCH FL, 1992, BIOCHIM BIOPHYS ACTA, V1113, P71, DOI 10.1016/0304-4157(92)90035-9
   Horvath SE, 2013, PROG LIPID RES, V52, P590, DOI 10.1016/j.plipres.2013.07.002
   Houtkooper RH, 2008, CELL MOL LIFE SCI, V65, P2493, DOI 10.1007/s00018-008-8030-5
   Khairallah RJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034402
   Kim JA, 2008, CIRC RES, V102, P401, DOI 10.1161/CIRCRESAHA.107.165472
   Klingenberg M, 2009, BBA-BIOMEMBRANES, V1788, P2048, DOI 10.1016/j.bbamem.2009.06.007
   Li J, 2010, CELL METAB, V12, P154, DOI 10.1016/j.cmet.2010.07.003
   Lowell BB, 2005, SCIENCE, V307, P384, DOI 10.1126/science.1104343
   Ma ZA, 2012, CURR DIABETES REV, V8, P69
   Ma ZA, 2012, EXP DIABETES RES, DOI 10.1155/2012/703538
   Maranzana E, 2013, ANTIOXID REDOX SIGN, V19, P1469, DOI 10.1089/ars.2012.4845
   McMillen IC, 2009, ADV EXP MED BIOL, V646, P71, DOI 10.1007/978-1-4020-9173-5_8
   MCMILLIN JB, 1992, AM J PHYSIOL, V263, pH1479, DOI 10.1152/ajpheart.1992.263.5.H1479
   Mejia EM, 2014, CHEM PHYS LIPIDS, V179, P11, DOI 10.1016/j.chemphyslip.2013.10.001
   Miquel E, 2014, FREE RADICAL BIO MED, V70, P204, DOI 10.1016/j.freeradbiomed.2014.02.019
   Monteiro JP, 2013, ARCH TOXICOL, V87, P2151, DOI 10.1007/s00204-013-1068-7
   Mulligan CM, 2012, CARDIOVASC RES, V94, P460, DOI 10.1093/cvr/cvs118
   Osman C, 2011, J CELL BIOL, V192, P7, DOI 10.1083/jcb.201006159
   Pan HJ, 2006, VASC PHARMACOL, V45, P65, DOI 10.1016/j.vph.2005.11.011
   Paradies G, 2014, ANTIOXID REDOX SIGN, V20, P1925, DOI 10.1089/ars.2013.5280
   Paradies G, 2014, BBA-BIOENERGETICS, V1837, P408, DOI 10.1016/j.bbabio.2013.10.006
   Paradies G, 2010, FREE RADICAL BIO MED, V48, P1286, DOI 10.1016/j.freeradbiomed.2010.02.020
   Pepe S, 1999, AM J PHYSIOL-HEART C, V276, pH149, DOI 10.1152/ajpheart.1999.276.1.H149
   Pessayre D, 2004, EUR J GASTROEN HEPAT, V16, P1095, DOI 10.1097/00042737-200411000-00003
   Petrosillo G, 2007, BBA-BIOENERGETICS, V1767, P1260, DOI 10.1016/j.bbabio.2007.07.011
   Pope S, 2008, BBA-BIOENERGETICS, V1777, P794, DOI 10.1016/j.bbabio.2008.03.011
   POWER GW, 1994, BIOCHEM MOL BIOL INT, V34, P671
   Ren MD, 2014, PROG LIPID RES, V55, P1, DOI 10.1016/j.plipres.2014.04.001
   ROBBLEE NM, 1984, J NUTR, V114, P263, DOI 10.1093/jn/114.2.263
   RUIZGUTIERREZ V, 1990, ANN NUTR METAB, V34, P350, DOI 10.1159/000177609
   Schlame M, 2000, PROG LIPID RES, V39, P257, DOI 10.1016/S0163-7827(00)00005-9
   Schlame M, 2005, CHEM PHYS LIPIDS, V138, P38, DOI 10.1016/j.chemphyslip.2005.08.002
   Schlame M, 1999, J LIPID RES, V40, P1585
   Schlame M, 2008, J LIPID RES, V49, P1607, DOI 10.1194/jlr.R700018-JLR200
   Schlame M, 2013, BBA-MOL CELL BIOL L, V1831, P582, DOI 10.1016/j.bbalip.2012.11.007
   Schlame M, 2009, BBA-BIOMEMBRANES, V1788, P2080, DOI 10.1016/j.bbamem.2009.04.019
   Schwall CT, 2012, BBA-BIOENERGETICS, V1817, P1588, DOI 10.1016/j.bbabio.2012.04.015
   Shi YG, 2010, J BIOMED RES, V24, P6, DOI 10.1016/S1674-8301(10)60003-6
   Simoes C, 2013, ARCH BIOCHEM BIOPHYS, V538, P95, DOI 10.1016/j.abb.2013.07.029
   Sparagna GC, 2009, J CARDIOVASC PHARM, V53, P290, DOI 10.1097/FJC.0b013e31819b5461
   Stavrovskaya IG, 2013, J LIPID RES, V54, P2623, DOI 10.1194/jlr.M036285
   Stefanyk LE, 2010, J MEMBRANE BIOL, V234, P207, DOI 10.1007/s00232-010-9247-4
   SWANSON JE, 1986, J NUTR, V116, P514, DOI 10.1093/jn/116.4.514
   Tamura Y, 2013, CELL METAB, V17, P709, DOI 10.1016/j.cmet.2013.03.018
   Taylor WA, 2002, BMC BIOCHEM, V3, DOI 10.1186/1471-2091-3-9
   Tsalouhidou S, 2006, J ANIM SCI, V84, P2818, DOI 10.2527/jas.2006-031
   Wang HYJ, 2007, J AM SOC MASS SPECTR, V18, P567, DOI 10.1016/j.jasms.2006.10.023
   Watkins SM, 2001, LIPIDS, V36, P247, DOI 10.1007/s11745-001-0714-8
   WOLFF RL, 1991, BIOCHIM BIOPHYS ACTA, V1082, P136, DOI 10.1016/0005-2760(91)90187-M
   YABUUCHI H, 1968, J NEUROCHEM, V15, P1383, DOI 10.1111/j.1471-4159.1968.tb05920.x
   YAMAOKA S, 1988, J NUTR, V118, P290, DOI 10.1093/jn/118.3.290
   YAMAOKA S, 1990, J NUTR, V120, P415, DOI 10.1093/jn/120.5.415
   Ye C, 2014, J BIOL CHEM, V289
   Zhang M, 2005, J BIOL CHEM, V280, P29403, DOI 10.1074/jbc.M504955200
   Zhuravleva E, 2012, MOL CELL BIOL, V32, P2685, DOI 10.1128/MCB.00312-12
NR 82
TC 26
Z9 29
U1 1
U2 40
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0145-479X
EI 1573-6881
J9 J BIOENERG BIOMEMBR
JI J. Bioenerg. Biomembr.
PD OCT
PY 2014
VL 46
IS 5
BP 447
EP 457
DI 10.1007/s10863-014-9555-y
PG 11
WC Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biophysics; Cell Biology
GA AP9YW
UT WOS:000342439200010
PM 24951897
DA 2025-06-11
ER

PT J
AU Daubenmier, J
   Moran, PJ
   Kristeller, J
   Acree, M
   Bacchetti, P
   Kemeny, ME
   Dallman, M
   Lustig, RH
   Grunfeld, C
   Nixon, DF
   Milush, JM
   Goldman, V
   Laraia, B
   Laugero, KD
   Woodhouse, L
   Epel, ES
   Hecht, FM
AF Daubenmier, Jennifer
   Moran, Patricia J.
   Kristeller, Jean
   Acree, Michael
   Bacchetti, Peter
   Kemeny, Margaret E.
   Dallman, Mary
   Lustig, Robert H.
   Grunfeld, Carl
   Nixon, Douglas F.
   Milush, Jeffrey M.
   Goldman, Veronica
   Laraia, Barbara
   Laugero, Kevin D.
   Woodhouse, Leslie
   Epel, Elissa S.
   Hecht, Frederick M.
TI Effects of a mindfulness-based weight loss intervention in adults with
   obesity: A randomized clinical trial
SO OBESITY
LA English
DT Article
ID METABOLIC SYNDROME; DIABETES-MELLITUS; HEART-DISEASE; LIFE-STYLE;
   MORTALITY; STRESS; METAANALYSIS; INDIVIDUALS; IMPACT; INDEX
AB ObjectiveTo determine whether adding mindfulness-based eating and stress management practices to a diet-exercise program improves weight loss and metabolic syndrome components.
   MethodsIn this study 194 adults with obesity were randomized to a 5.5-month program with or without mindfulness training and identical diet-exercise guidelines. Intention-to-treat analyses with multiple imputation were used for missing data. The primary outcome was 18-month weight change.
   ResultsEstimated effects comparing the mindfulness to control arm favored the mindfulness arm in (a) weight loss at 12 months, -1.9 kg (95% CI: -4.5, 0.8; P=0.17), and 18 months, -1.7 kg (95% CI: -4.7, 1.2; P=0.24), though not statistically significant; (b) changes in fasting glucose at 12 months, -3.1 mg/dl (95% CI: -6.3, 0.1; P=0.06), and 18 months, -4.1 mg/dl (95% CI: -7.3, -0.9; P=0.01); and (c) changes in triglyceride/HDL ratio at 12 months, -0.57 (95% CI: -0.95, -0.18; P=0.004), and 18 months, -0.36 (95% CI: -0.74, 0.03; P=0.07). Estimates for other metabolic risk factors were not statistically significant, including waist circumference, blood pressure, and C-reactive protein.
   ConclusionsMindfulness enhancements to a diet-exercise program did not show substantial weight loss benefit but may promote long-term improvement in some aspects of metabolic health in obesity that requires further study.
C1 [Daubenmier, Jennifer; Moran, Patricia J.; Acree, Michael; Goldman, Veronica; Hecht, Frederick M.] Univ Calif San Francisco, Osher Ctr Integrat Med, San Francisco, CA 94143 USA.
   [Daubenmier, Jennifer; Dallman, Mary; Grunfeld, Carl; Laraia, Barbara; Epel, Elissa S.; Hecht, Frederick M.] Univ Calif San Francisco, Ctr Obes Assessment Study & Treatment, San Francisco, CA 94143 USA.
   [Daubenmier, Jennifer; Grunfeld, Carl; Milush, Jeffrey M.; Hecht, Frederick M.] Univ Calif San Francisco, Dept Med, San Francisco, CA USA.
   [Kristeller, Jean] Indiana State Univ, Dept Psychol, Terre Haute, IN 47809 USA.
   [Bacchetti, Peter] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
   [Kemeny, Margaret E.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA.
   [Dallman, Mary; Epel, Elissa S.] Univ Calif San Francisco, Dept Physiol, Box 0444, San Francisco, CA USA.
   [Lustig, Robert H.] Univ Calif San Francisco, Dept Pediat, San Francisco, CA USA.
   [Grunfeld, Carl] Vet Affairs Med Ctr, San Francisco, CA 94121 USA.
   [Nixon, Douglas F.] Univ Calif San Francisco, Div Expt Med, San Francisco, CA 94143 USA.
   [Nixon, Douglas F.] George Washington Univ, Dept Microbiol Immunol & Trop Med, Washington, DC USA.
   [Laraia, Barbara] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA.
   [Laugero, Kevin D.; Woodhouse, Leslie] USDA, Western Human Nutr Res Ctr, Davis, CA USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   Indiana State University; University of California System; University of
   California San Francisco; University of California System; University of
   California San Francisco; University of California System; University of
   California San Francisco; University of California System; University of
   California San Francisco; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); University of California System; University
   of California San Francisco; George Washington University; University of
   California System; University of California Berkeley; United States
   Department of Agriculture (USDA)
RP Daubenmier, J; Hecht, FM (corresponding author), Univ Calif San Francisco, Osher Ctr Integrat Med, San Francisco, CA 94143 USA.; Daubenmier, J; Hecht, FM (corresponding author), Univ Calif San Francisco, Ctr Obes Assessment Study & Treatment, San Francisco, CA 94143 USA.; Daubenmier, J; Hecht, FM (corresponding author), Univ Calif San Francisco, Dept Med, San Francisco, CA USA.
EM jennifer.daubenmier@ucsf.edu; rick.hecht@ucsf.edu
RI Lustig, Robert/O-9380-2019; Nixon, Douglas/AAU-5734-2020; Dallman,
   Mary/B-4816-2010; Epel, Elissa/ABI-6703-2022; Laraia,
   Barbara/GXG-1829-2022
OI Hecht, Frederick/0000-0002-5782-1171
FU NIH grants from the National Center for Complementary and Alternative
   Medicine (NCCAM) [P01AT005013, K24AT007827, K01AT004199]; National
   Center for Advancing Translational Sciences, UCSF-CTSI [UL1 TR000004];
   National Center for Complementary and Integrative Health [K24AT007827]
   Funding Source: NIH RePORTER; National Institute of Diabetes and
   Digestive and Kidney Diseases [P30DK098722] Funding Source: NIH RePORTER
FX This study was supported by NIH grants from the National Center for
   Complementary and Alternative Medicine (NCCAM) P01AT005013 (Hecht),
   K24AT007827 (Hecht), and K01AT004199 (Daubenmier), as well as the
   National Center for Advancing Translational Sciences, UCSF-CTSI Grant
   Number UL1 TR000004.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   [Anonymous], CHI WALKING 5 MINDFU
   [Anonymous], 2011, NCHS DATA BRIEF
   [Anonymous], JAMA INTERN MED
   [Anonymous], 1990, FULL CATASTROPHE LIV, DOI DOI 10.1037/032287
   [Anonymous], NAT REV ENDOCRINOL
   [Anonymous], J BEHAV MED IN PRESS
   Barr ELM, 2007, CIRCULATION, V116, P151, DOI 10.1161/CIRCULATIONAHA.106.685628
   Brown KW, 2007, PSYCHOL INQ, V18, P211, DOI 10.1080/10478400701598298
   Burke LE, 2011, J AM DIET ASSOC, V111, P92, DOI 10.1016/j.jada.2010.10.008
   Crane RS, 2013, ASSESSMENT, V20, P681, DOI 10.1177/1073191113490790
   Daubenmier J, 2011, J OBES, V2011, DOI 10.1155/2011/651936
   Franz MJ, 2007, J AM DIET ASSOC, V107, P1755, DOI 10.1016/j.jada.2007.07.017
   Jakicic JM, 2012, JAMA-J AM MED ASSOC, V307, P2617, DOI 10.1001/jama.2012.6866
   Jensen MD, 2014, OBESITY, V22, pS5, DOI 10.1002/oby.20821
   Jensen MD, 2014, JAMA-J AM MED ASSOC, V311, P23, DOI 10.1001/jama.2013.282546
   Katterman SN, 2014, EAT BEHAV, V15, P197, DOI 10.1016/j.eatbeh.2014.01.005
   Kiernan M, 2013, J CONSULT CLIN PSYCH, V81, P336, DOI 10.1037/a0030544
   Kim DM, 2006, PSYCHOTHER RES, V16, P161, DOI 10.1080/10503300500264911
   Knowler William C, 2002, N Engl J Med, V346, P393, DOI 10.1056/NEJMoa012512
   Kristeller J L, 1999, J Health Psychol, V4, P357, DOI 10.1177/135910539900400305
   Kristeller J, 2014, MINDFULNESS, V5, P282, DOI 10.1007/s12671-012-0179-1
   Kristeller Jean L, 2011, Eat Disord, V19, P49, DOI 10.1080/10640266.2011.533605
   Li L, 2013, J ENDOCRINOL, V217, P175, DOI 10.1530/JOE-12-0559
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Miller CK, 2012, J ACAD NUTR DIET, V112, P1835, DOI 10.1016/j.jand.2012.07.036
   Mozumdar A, 2011, DIABETES CARE, V34, P216, DOI 10.2337/dc10-0879
   O'Reilly GA, 2014, OBES REV, V15, P453, DOI 10.1111/obr.12156
   Papadaki A, 2014, NUTRITION, V30, P410, DOI 10.1016/j.nut.2013.09.001
   Rosmond R, 2005, PSYCHONEUROENDOCRINO, V30, P1, DOI 10.1016/j.psyneuen.2004.05.007
   Schmidt MI, 2005, DIABETES CARE, V28, P2013, DOI 10.2337/diacare.28.8.2013
   Shin JA, 2013, J DIABETES INVEST, V4, P334, DOI 10.1111/jdi.12075
   Sterne JAC, 2009, BMJ-BRIT MED J, V339, DOI 10.1136/bmj.b2393
   Vega GL, 2014, J INVEST MED, V62, P345, DOI 10.2310/JIM.0000000000000044
   Wansink B, 2010, PHYSIOL BEHAV, V100, P454, DOI 10.1016/j.physbeh.2010.05.003
   Wardle J, 2011, OBESITY, V19, P771, DOI 10.1038/oby.2010.241
NR 36
TC 97
Z9 112
U1 0
U2 48
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD APR
PY 2016
VL 24
IS 4
BP 794
EP 804
DI 10.1002/oby.21396
PG 11
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA DI6MM
UT WOS:000373613200008
PM 26955895
OA Green Published, Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Chan, KC
   Pen, PJ
   Yin, MC
AF Chan, Kung-chi
   Pen, Pei-Jain
   Yin, Mei-chin
TI Anticoagulatory and Antiinflammatory Effects of Astaxanthin in Diabetic
   Rats
SO JOURNAL OF FOOD SCIENCE
LA English
DT Article
DE astaxanthin; coagulation; diabetes; reactive oxygen species
ID VON-WILLEBRAND-FACTOR; METABOLIC SYNDROME; OXIDATIVE STRESS; MESANGIAL
   CELLS; HYPERGLYCEMIA; COAGULATION; ATHEROTHROMBOSIS; NEUTROPHILS;
   DYSFUNCTION; CYTOKINES
AB Astaxanthin at 0.01 or 0.05% of the diet was supplied to diabetic rats for 12 wk. Astaxanthin intake significantly increased its deposit in plasma, and retained glutathione content, reduced the production of reactive oxygen species, interleukin-6, tumor necrosis factor-a, and monocyte chemoattractant protein-1 in blood and kidney of diabetic rats (P < 0.05). Astaxanthin treatments also significantly decreased plasma levels of C-reactive protein and von Willebrand factor in diabetic rats (P < 0.05). Astaxanthin intake at 0.05% significantly diminished plasminogen activator inhibitor-1 and factor VII activities, enhanced antithrombin-III and protein C activities in circulation (P < 0.05). These results support that astaxanthin could attenuate diabetes associated coagulatory, oxidative, and inflammatory stress.
C1 [Yin, Mei-chin] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung, Taiwan.
   [Yin, Mei-chin] China Med Univ, Dept Nutr, Taichung, Taiwan.
   [Chan, Kung-chi; Pen, Pei-Jain] Providence Univ, Dept Food & Nutr, Taichung, Taiwan.
C3 Asia University Taiwan; China Medical University Taiwan; Providence
   University - Taiwan
RP Yin, MC (corresponding author), Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung, Taiwan.
EM mcyin@mail.cmu.edu.tw
FU Natl. Science Council, Taiwan, ROC [NSC 99-2320-B-126-001]
FX This study was supported by a grant from Natl. Science Council, Taiwan,
   ROC (NSC 99-2320-B-126-001).
CR ALI SF, 1992, NEUROTOXICOLOGY, V13, P637
   Asakawa H, 2000, J DIABETES COMPLICAT, V14, P121, DOI 10.1016/S1056-8727(00)00075-1
   Aso Y, 2003, DIABETIC MED, V20, P930, DOI 10.1046/j.1464-5491.2003.01058.x
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   CERIELLO A, 1995, DIABETES, V44, P924, DOI 10.2337/diabetes.44.8.924
   Chan KC, 2009, J FOOD SCI, V74, pH225, DOI 10.1111/j.1750-3841.2009.01274.x
   Chao CY, 2010, MOL NUTR FOOD RES, V54, P388, DOI 10.1002/mnfr.200900087
   Delmastro MM, 2011, CLIN DEV IMMUNOL, DOI 10.1155/2011/593863
   Drimal Jan, 2008, Endocr Regul, V42, P129
   Eigenbrot C, 2002, TRENDS CARDIOVAS MED, V12, P19, DOI 10.1016/S1050-1738(01)00139-6
   Geerlings SE, 2000, EUR J CLIN INVEST, V30, P995, DOI 10.1046/j.1365-2362.2000.00745.x
   Hatanaka E, 2006, CLIN EXP IMMUNOL, V146, P443, DOI 10.1111/j.1365-2249.2006.03229.x
   Herkert O, 2004, ANTIOXID REDOX SIGN, V6, P765, DOI 10.1089/1523086041361695
   Kessler L, 1998, DIABETES METAB, V24, P327
   Lee EA, 2005, KIDNEY INT, V67, P1762, DOI 10.1111/j.1523-1755.2005.00274.x
   Lemkes BA, 2010, J THROMB HAEMOST, V8, P1663, DOI 10.1111/j.1538-7836.2010.03910.x
   Lin CY, 2009, J AGR FOOD CHEM, V57, P6661, DOI 10.1021/jf9015202
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   Manabe E, 2008, J CELL BIOCHEM, V103, P1925, DOI 10.1002/jcb.21583
   Marin DP, 2011, INT IMMUNOPHARMACOL, V11, P103, DOI 10.1016/j.intimp.2010.10.013
   Meerarani P, 2006, CURR MOL MED, V6, P501, DOI 10.2174/156652406778018680
   MYRUP B, 1995, DIABETOLOGIA, V38, P73, DOI 10.1007/BF02369355
   Naito Y, 2004, BIOFACTORS, V20, P49, DOI 10.1002/biof.5520200105
   Navarro-González JF, 2008, J AM SOC NEPHROL, V19, P433, DOI 10.1681/ASN.2007091048
   Nwose EU, 2009, REDOX REP, V14, P55, DOI 10.1179/135100009X392458
   Otton R, 2010, CHEM-BIOL INTERACT, V186, P306, DOI 10.1016/j.cbi.2010.05.011
   Palomo I, 2006, INT J MOL MED, V18, P969
   Park JS, 2010, NUTR METAB, V7, DOI 10.1186/1743-7075-7-18
   Takaishi H, 2003, BIOCHEM BIOPH RES CO, V305, P122, DOI 10.1016/S0006-291X(03)00712-5
   Urano T, 2000, SEMIN THROMB HEMOST, V26, P39, DOI 10.1055/s-2000-9801
   Vischer UM, 2006, J THROMB HAEMOST, V4, P1186, DOI 10.1111/j.1538-7836.2006.01949.x
   Yamada T, 2000, DIABETES RES CLIN PR, V49, P23, DOI 10.1016/S0168-8227(00)00134-0
NR 32
TC 43
Z9 49
U1 0
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-1147
EI 1750-3841
J9 J FOOD SCI
JI J. Food Sci.
PD FEB
PY 2012
VL 77
IS 2
BP H76
EP H80
DI 10.1111/j.1750-3841.2011.02558.x
PG 5
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 897YU
UT WOS:000300700100014
PM 22309505
DA 2025-06-11
ER

PT J
AU Kim, HJ
   Shin, SY
   Jeong, SH
AF Kim, Ho Joon
   Shin, Sam Yi
   Jeong, Seong Hoon
TI Nature and Extent of Physical Comorbidities Among Korean Patients With
   Mental Illnesses: Pairwise and Network Analysis Based on Health
   Insurance Claims Data
SO PSYCHIATRY INVESTIGATION
LA English
DT Article
DE Physical comorbidity; Healthcare system; Comorbidity network; Health
   insurance claims data; Severe mental
ID GENERAL-POPULATION; DISORDERS; SCHIZOPHRENIA; DEPRESSION;
   MULTIMORBIDITY; ASSOCIATION; PERSPECTIVE; BEHAVIORS; MORTALITY; PEOPLE
AB Objective The nature of physical comorbidities in patients with mental illness may differ according to diagnosis and personal charac-teristics. We investigated this complexity by conventional logistic regression and network analysis. Methods A health insurance claims data in Korea was analyzed. For every combination of psychiatric and physical diagnoses, odds ra-tios were calculated adjusting age and sex. From the patient-diagnosis data, a network of diagnoses was constructed using Jaccard coeffi-cient as the index of comorbidity. Results In 1,017,024 individuals, 77,447 (7.6%) were diagnosed with mental illnesses. The number of physical diagnoses among them was 11.2, which was 1.6 times higher than non-psychiatric groups. The most noticeable associations were 1) neurotic illnesses with gas-trointestinal/pain disorders and 2) dementia with fracture, Parkinson's disease, and cerebrovascular accidents. Unexpectedly, the diagno-sis of metabolic syndrome was only scarcely found in patients with severe mental illnesses (SMIs). However, implicit associations be-tween metabolic syndrome and SMIs were suggested in comorbidity networks. Conclusion Physical comorbidities in patients with mental illnesses were more extensive than those with other disease categories. However, the result raised questions as to whether the medical resources were being diverted to less serious conditions than more urgent conditions in patients with SMIs.
C1 [Kim, Ho Joon; Jeong, Seong Hoon] Eulji Univ, Daejeon Eulji Med Ctr, Dept Psychiat, Sch Med, 77 Gyeryong Ro 771beon Gil, Daejeon 34824, South Korea.
   [Shin, Sam Yi] Healers Hosp, Dept Psychiat, Busan, South Korea.
C3 Eulji University
RP Jeong, SH (corresponding author), Eulji Univ, Daejeon Eulji Med Ctr, Dept Psychiat, Sch Med, 77 Gyeryong Ro 771beon Gil, Daejeon 34824, South Korea.
EM AnselmJeong@gmail.com
RI Jeong, Seong/NES-0289-2025
OI Shin, Sam Yi/0000-0003-2268-3968
CR Aguado A, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-59336-1
   Balaur I, 2017, BIOINFORMATICS, V33, P1096, DOI 10.1093/bioinformatics/btw731
   Bijl RV, 2000, AM J PUBLIC HEALTH, V90, P602, DOI 10.2105/AJPH.90.4.602
   Boeckle M, 2016, NEUROIMAGE-CLIN, V11, P606, DOI 10.1016/j.nicl.2016.04.001
   Boerema AM, 2016, BMC PSYCHIATRY, V16, DOI 10.1186/s12888-016-0790-0
   Bremmer MA, 2008, J AFFECT DISORDERS, V106, P249, DOI 10.1016/j.jad.2007.07.002
   Cameron OG, 2004, BIOL PSYCHIAT, V56, P875, DOI 10.1016/j.biopsych.2004.08.007
   Carney CP, 2006, J GEN INTERN MED, V21, P1133, DOI 10.1111/j.1525-1497.2006.00563.x
   Cramer AOJ, 2010, BEHAV BRAIN SCI, V33, P137, DOI 10.1017/S0140525X09991567
   Crawford MJ, 2014, BRIT J PSYCHIAT, V205, P473, DOI 10.1192/bjp.bp.113.142521
   Crump C, 2013, AM J PSYCHIAT, V170, P324, DOI 10.1176/appi.ajp.2012.12050599
   Ehlert U, 2001, BIOL PSYCHOL, V57, P141, DOI 10.1016/S0301-0511(01)00092-8
   Firth J, 2019, LANCET PSYCHIAT, V6, P675, DOI 10.1016/S2215-0366(19)30132-4
   Fotouhi Babak, 2018, Appl Netw Sci, V3, P46, DOI 10.1007/s41109-018-0101-4
   del Valle EPG, 2019, J BIOMED INFORM, V94, DOI 10.1016/j.jbi.2019.103206
   Goh KI, 2007, P NATL ACAD SCI USA, V104, P8685, DOI 10.1073/pnas.0701361104
   Haussleiter I, 2021, HEALTH SCI REP-US, V4, DOI 10.1002/hsr2.226
   Heinig I, 2021, COMMUNITY MENT HLT J, V57, P1505, DOI 10.1007/s10597-020-00767-5
   Heo YC, 2019, INT J MENT HEALTH SY, V13, DOI 10.1186/s13033-019-0266-y
   Hidalgo CA, 2009, PLOS COMPUT BIOL, V5, DOI 10.1371/journal.pcbi.1000353
   Hu JX, 2016, NAT REV GENET, V17, P615, DOI 10.1038/nrg.2016.87
   Jansen L, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194029
   Jeong E, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-15647-4
   Jiang YF, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-21779-y
   Katon WJ, 2003, BIOL PSYCHIAT, V54, P216, DOI 10.1016/S0006-3223(03)00273-7
   Khan A, 2018, INT J MED INFORM, V115, P1, DOI 10.1016/j.ijmedinf.2018.04.001
   Kim JH, 2016, PSYCHIAT INVEST, V13, P496, DOI 10.4306/pi.2016.13.5.496
   Kim JH, 2016, J BIOMED INFORM, V61, P276, DOI 10.1016/j.jbi.2016.05.002
   Kim SW, 2019, CLIN PSYCHOPHARM NEU, V17, P279, DOI 10.9758/cpn.2019.17.2.279
   Klabunde CN, 2007, ANN EPIDEMIOL, V17, P584, DOI 10.1016/j.annepidem.2007.03.011
   Klabunde CN, 2002, MED CARE, V40, P26
   Ko Y, 2016, SCI REP-UK, V6, DOI 10.1038/srep39433
   Köteles F, 2017, J PSYCHOSOM RES, V101, P1, DOI 10.1016/j.jpsychores.2017.07.011
   Larson SL, 2004, PSYCHOL MED, V34, P211, DOI 10.1017/S0033291703001041
   Marx P, 2017, PLOS COMPUT BIOL, V13, DOI 10.1371/journal.pcbi.1005487
   Maxwell M, 2013, BMC FAM PRACT, V14, DOI 10.1186/1471-2296-14-46
   Momen NC, 2020, NEW ENGL J MED, V382, P1721, DOI 10.1056/NEJMoa1915784
   Nelis SM, 2019, AGE AGEING, V48, P361, DOI 10.1093/ageing/afy155
   Ni P, 2020, IEEE ACM T COMPUT BI, V17, P906, DOI 10.1109/TCBB.2018.2817624
   Nocaj A., 2015, JGAA, V19, P595, DOI DOI 10.7155/JGAA.00370
   Pan YJ, 2020, EPIDEMIOL PSYCH SCI, V29, DOI 10.1017/S2045796020000694
   Park S, 2016, BMJ-BRIT MED J, V355, DOI 10.1136/bmj.i5745
   Park S, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18084187
   Pavlopoulos GA, 2018, GIGASCIENCE, V7, DOI 10.1093/gigascience/giy014
   Plana-Ripoll O, 2019, JAMA PSYCHIAT, V76, P259, DOI 10.1001/jamapsychiatry.2018.3658
   Romain AJ, 2018, J AFFECT DISORDERS, V225, P381, DOI 10.1016/j.jad.2017.08.065
   Sartorius N, 2018, ACTA PSYCHIAT SCAND, V137, P369, DOI 10.1111/acps.12888
   Scott KM, 2016, JAMA PSYCHIAT, V73, P150, DOI 10.1001/jamapsychiatry.2015.2688
   Seto H, 2017, BIOPSYCHOSOC MED, V11, DOI 10.1186/s13030-017-0110-z
   Shoshi A, 2018, J INTEGR BIOINFORMAT, V15, DOI 10.1515/jib-2018-0049
   Smith DP, 2013, BMJ OPEN, V3, DOI [10.1136/bmjopen-2013-003244, 10.1136/bmjopen-2013-002808]
   Söderquist F, 2020, BMC PSYCHIATRY, V20, DOI 10.1186/s12888-020-02940-2
   Steffen A, 2020, BMC PSYCHIATRY, V20, DOI 10.1186/s12888-020-02546-8
   Summer G, 2015, BIOINFORMATICS, V31, P3868, DOI 10.1093/bioinformatics/btv460
   Tabarés-Seisdedos R, 2009, J CLIN PSYCHIAT, V70, P1191, DOI 10.4088/JCP.08lr04991
   Vancampfort D, 2017, GEN HOSP PSYCHIAT, V45, P1, DOI 10.1016/j.genhosppsych.2016.11.002
   Walker ER, 2015, JAMA PSYCHIAT, V72, P334, DOI 10.1001/jamapsychiatry.2014.2502
   Wittchen Hans-Ulrich, 2003, Dialogues Clin Neurosci, V5, P115
   Yang CY, 2020, NEUROPSYCH DIS TREAT, V16, P2073, DOI 10.2147/NDT.S261223
   Zimmerman M, 2016, CAN J PSYCHIAT, V61, P71, DOI 10.1177/0706743715625935
NR 60
TC 2
Z9 2
U1 0
U2 4
PU KOREAN NEUROPSYCHIATRIC ASSOC
PI SEOUL
PA RN 522, G-FIVE CENTRAL PLAZA 1685-8 SEOCHO 4-DONG, SEOCHO-GU, SEOUL,
   137-882, SOUTH KOREA
EI 1976-3026
J9 PSYCHIAT INVEST
JI Psychiatry Investig.
PD JUN
PY 2022
VL 19
IS 6
BP 488
EP 499
DI 10.30773/pi.2022.0068
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 3L7KL
UT WOS:000834939900011
PM 35753688
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Segura, AG
   Martínez-Pinteño, A
   Gassó, P
   Rodríguez, N
   Bioque, M
   Cuesta, MJ
   González-Peñas, J
   García-Rizo, C
   Lobo, A
   González-Pinto, A
   García-Alcón, A
   Roldán, A
   Vista, E
   Castro-Fornieles, J
   Mané, A
   Saiz, J
   Bernardo, M
   Mas, S
AF Segura, Alex G.
   Martinez-Pinteno, Albert
   Gasso, Patricia
   Rodriguez, Natalia
   Bioque, Miquel
   Cuesta, Manuel J.
   Gonzalez-Penas, Javier
   Garcia-Rizo, Clemente
   Lobo, Antonio
   Gonzalez-Pinto, Ana
   Garcia-Alcon, Alicia
   Roldan, Alexendra
   Vista, Eduard
   Castro-Fornieles, Josefina
   Mane, Anne
   Saiz, Jeronimo
   Bernardo, Miguel
   Mas, Sergi
CA PEPs Grp
TI Metabolic polygenic risk scores effect on antipsychotic-induced
   metabolic dysregulation: A longitudinal study in a first episode
   psychosis cohort
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE Psychotic disorders; Metabolic syndrome; Polygenic risk score
ID 1ST-EPISODE PSYCHOSIS; BIPOLAR DISORDER; SCHIZOPHRENIA; ASSOCIATION;
   ABNORMALITIES; METAANALYSIS; PREVALENCE; PSYCHIATRY; PEOPLE; DRUGS
AB Objective: Metabolic syndrome is a health-threatening condition suffered by approximately one third of schizophrenia patients and largely attributed to antipsychotic medication. Previous evidence reports a common genetic background of psychotic and metabolic disorders. In this study, we aimed to assess the role of polygenic risk scores (PRSs) on the progression of the metabolic profile in a first-episode psychosis (FEP) cohort. Method: Of the 231 FEP individuals included in the study, 192-220 participants were included in basal analysis and 118-179 in longitudinal 6-month models. Eleven psychopathologic and metabolic PRSs were constructed. Basal and longitudinal PRSs association with metabolic measurements was assessed by statistical analyses.Results: No major association of psychopathological PRSs with the metabolic progression was found. However, high risk individuals for depression and cholesterol-related PRSs reported a higher increase of cholesterol levels during the follow-up (FDR <= 0.023 for all analyses). Their effect was comparable to other well-established pharmacological and environmental risk factors (explaining at least 1.2% of total variance).Conclusion: Our findings provide new evidence of the effects of metabolic genetic risk on the development of metabolic dysregulation. The future establishment of genetic profiling tools in clinical procedures could enable practitioners to better personalize antipsychotic treatment selection and dosage.
C1 [Segura, Alex G.; Martinez-Pinteno, Albert; Gasso, Patricia; Rodriguez, Natalia; Mas, Sergi] Univ Barcelona, Dept Clin Fdn, Pharmacol Unit, Barcelona 08036, Spain.
   [Gasso, Patricia; Bioque, Miquel; Gonzalez-Penas, Javier; Garcia-Rizo, Clemente; Lobo, Antonio; Gonzalez-Pinto, Ana; Garcia-Alcon, Alicia; Roldan, Alexendra; Vista, Eduard; Castro-Fornieles, Josefina; Mane, Anne; Saiz, Jeronimo; Bernardo, Miguel; Mas, Sergi] Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid 28029, Spain.
   [Gasso, Patricia; Bioque, Miquel; Garcia-Rizo, Clemente] Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona 08036, Spain.
   [Bioque, Miquel; Garcia-Rizo, Clemente; Bernardo, Miguel] Hosp Clin Barcelona, Barcelona Clin Schizophrenia Unit, Neurosci Inst, Barcelona 08036, Spain.
   [Cuesta, Manuel J.] Complejo Hosp Navarra, Dept Psychiat, Pamplona 31008, Spain.
   [Cuesta, Manuel J.] Navarra Inst Hlth Res IdiSNA, Pamplona, Spain.
   [Gonzalez-Penas, Javier; Garcia-Alcon, Alicia] Inst Invest Sanitaria Gregorio Maran IiSGM, Hosp Gen Univ Gregorio Maranon, Inst Psychiat & Mental Hlth, Dept Child & Adolescent Psychiat, Madrid 28007, Spain.
   [Lobo, Antonio] Univ Zaragoza, Dept Med & Psychiat, Zaragoza 50009, Spain.
   [Lobo, Antonio] Inst Invest Sanitaria Aragon IIS Aragon, Zaragoza 50009, Spain.
   [Gonzalez-Pinto, Ana] Hosp Univ Alava, Vitoria 01009, Spain.
   [Gonzalez-Pinto, Ana] Inst Invest Sanitaria Bioaraba, Vitoria 01009, Spain.
   [Gonzalez-Pinto, Ana] Univ Basque Country, Vizcaya 48940, Spain.
   [Roldan, Alexendra] Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Inst Invest Biomed St Pau IIB SANTPAU, Psychiat Dept, Barcelona 08041, Spain.
   [Vista, Eduard] Hosp Clin Barcelona, Barcelona 08036, Spain.
   [Vista, Eduard; Bernardo, Miguel] Univ Barcelona, Dept Med, Barcelona 08036, Spain.
   [Castro-Fornieles, Josefina] Hosp Clin Barcelona, Clin Inst Neurosci, Dept Child & Adolescent Psychiat & Psychol, Barcelona 08036, Spain.
   [Mane, Anne] Autonomous Univ Barcelona, Hosp del Mar Med Res Inst IMIM, Barcelona 08003, Spain.
   [Saiz, Jeronimo] Univ Alcala, Hosp Univ Ramon & Cajal, IRYCIS, Madrid 28034, Spain.
C3 University of Barcelona; CIBER - Centro de Investigacion Biomedica en
   Red; CIBERSAM; University of Barcelona; Hospital Clinic de Barcelona;
   IDIBAPS; University of Barcelona; Hospital Clinic de Barcelona; Servicio
   Navarro de Salud - Osasunbidea; University of Navarra; General
   University Gregorio Maranon Hospital; University of Zaragoza; University
   Hospital of Araba; Bioaraba Health Research Institute; University of
   Basque Country; Autonomous University of Barcelona; Hospital of Santa
   Creu i Sant Pau; University of Barcelona; Hospital Clinic de Barcelona;
   University of Barcelona; University of Barcelona; Hospital Clinic de
   Barcelona; Hospital del Mar Research Institute; Hospital del Mar;
   Autonomous University of Barcelona; Universidad de Alcala; Hospital
   Universitario Ramon y Cajal
RP Mas, S (corresponding author), Univ Barcelona, Dept Clin Fdn, IDIBAPS, CIBERSAM, Casanova 143, E-08036 Barcelona, Spain.
EM sergimash@ub.edu
RI Rodriguez, Natalia/HNB-5559-2023; Martínez-Pinteño,
   Albert/GWM-5523-2022; Bernardo, Miquel/P-3049-2015; González-Peñas,
   Javier/ABC-8818-2021; Torres, Miguel/HZK-8113-2023; Gasso,
   Patricia/KEI-8686-2024; Vieta, Eduard/Y-2919-2019; Di Carlo,
   Antonio/AAB-9776-2022; Cuesta, Manuel/HLX-6728-2023; Mas,
   Sergi/AAD-1996-2019; Rivero, Olga/AAA-8059-2020; Vieta,
   Eduard/I-6330-2013; Bioque, Miquel/ACC-0014-2022; garcia-rizo,
   clemente/C-5520-2019
OI GARCIA ALCON, ALICIA/0000-0003-1777-1795; Mas,
   Sergi/0000-0003-3336-6298; Gonzalez-Penas, Javier/0000-0002-3850-3012;
   Segura, Alex G/0000-0002-9398-2183; Rivero, Olga/0000-0002-2664-4053;
   mane santacana, anna/0000-0003-2127-349X; Vieta,
   Eduard/0000-0002-0548-0053; Martinez Pinteno,
   Albert/0000-0003-2035-5979; Bioque, Miquel/0000-0001-6887-7149;
   garcia-rizo, clemente/0000-0002-4855-1608; Gasso,
   Patricia/0000-0001-6930-3454
CR [Anonymous], 1994, DSM 4
   Barton BB, 2020, EXPERT OPIN DRUG SAF, V19, P295, DOI 10.1080/14740338.2020.1713091
   Bernardo M, 2017, SCHIZOPHR RES, V189, P181, DOI 10.1016/j.schres.2017.01.058
   Bernardo M, 2013, REV PSIQUIATR SALUD, V6, P4, DOI 10.1016/j.rpsm.2012.11.001
   Bioque M, 2016, INT J NEUROPSYCHOPH, V19, DOI 10.1093/ijnp/pyv121
   Bulla J, 2017, INT J SOC PSYCHIATR, V63, P550, DOI 10.1177/0020764017716696
   Choi SW, 2020, NAT PROTOC, V15, P2759, DOI 10.1038/s41596-020-0353-1
   Choi SW, 2019, GIGASCIENCE, V8, DOI 10.1093/gigascience/giz082
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   Das S, 2016, NAT GENET, V48, P1284, DOI 10.1038/ng.3656
   Delacrétaza A, 2017, PHARMACOGENET GENOM, V27, P464, DOI 10.1097/FPC.0000000000000313
   Eeltink E, 2021, NEUROSCI BIOBEHAV R, V121, P119, DOI 10.1016/j.neubiorev.2020.11.021
   Fernandez-Egea E, 2008, SCHIZOPHR RES, V103, P110, DOI 10.1016/j.schres.2008.04.017
   Garcia-Rizo C, 2017, EUR PSYCHIAT, V41, P42, DOI 10.1016/j.eurpsy.2016.10.001
   Gardner DM, 2010, AM J PSYCHIAT, V167, P686, DOI 10.1176/appi.ajp.2009.09060802
   Gassó P, 2020, J PSYCHOPHARMACOL, V34, P514, DOI 10.1177/0269881120903462
   Habtewold TD, 2020, J PSYCHOSOM RES, V132, DOI 10.1016/j.jpsychores.2020.109968
   Hiemstra M, 2018, DRUG ALCOHOL DEPEN, V190, P143, DOI 10.1016/j.drugalcdep.2018.05.024
   Howard DM, 2019, NAT NEUROSCI, V22, P343, DOI 10.1038/s41593-018-0326-7
   Janssens ACJW, 2019, HUM MOL GENET, V28, pR143, DOI 10.1093/hmg/ddz205
   Kember RL, 2018, TRANSL PSYCHIAT, V8, DOI 10.1038/s41398-018-0226-3
   Lagou V, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-020-19366-9
   Leucht S, 2013, LANCET, V382, P951, DOI 10.1016/S0140-6736(13)60733-3
   Lin YF, 2018, TRANSL PSYCHIAT, V8, DOI 10.1038/s41398-018-0144-4
   Maj C, 2020, EARLY INTERV PSYCHIA, V14, P507, DOI 10.1111/eip.12906
   Malan-Müller S, 2016, SCHIZOPHR RES, V170, P1, DOI 10.1016/j.schres.2015.11.011
   Mas S, 2020, SCHIZOPHRENIA BULL, V46, P1019, DOI 10.1093/schbul/sbaa012
   Mistry S, 2018, SCHIZOPHR RES, V197, P2, DOI 10.1016/j.schres.2017.10.037
   Mistry S, 2018, J AFFECT DISORDERS, V234, P148, DOI 10.1016/j.jad.2018.02.005
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P295, DOI 10.1093/schbul/sbs082
   Morris AP, 2012, NAT GENET, V44, P981, DOI 10.1038/ng.2383
   Perkins DO, 2020, AM J PSYCHIAT, V177, P155, DOI 10.1176/appi.ajp.2019.18060721
   Perry BI, 2016, LANCET PSYCHIAT, V3, P1049, DOI 10.1016/S2215-0366(16)30262-0
   Pillinger T, 2020, LANCET PSYCHIAT, V7, P64, DOI 10.1016/S2215-0366(19)30416-X
   Pina-Camacho L, 2016, SCHIZOPHRENIA BULL, V42, P344, DOI 10.1093/schbul/sbv128
   Pisanu C, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.00617
   Pulit SL, 2019, HUM MOL GENET, V28, P166, DOI 10.1093/hmg/ddy327
   Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795
   R Core Team, 2017, R: A Language and Environment for Statistical Computing
   Radulescu E, 2020, MOL PSYCHIATR, V25, P791, DOI 10.1038/s41380-018-0304-1
   Ripke S, 2020, Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia
   Salagre E, 2019, REV PSIQUIATR SALUD, V12, P1, DOI 10.1016/j.rpsm.2018.10.001
   Samson SL, 2014, ENDOCRIN METAB CLIN, V43, P1, DOI 10.1016/j.ecl.2013.09.009
   Santoro ML, 2018, TRANSL PSYCHIAT, V8, DOI 10.1038/s41398-018-0230-7
   Siafis S, 2018, CURR NEUROPHARMACOL, V16, P1210, DOI 10.2174/1570159X15666170630163616
   Smeland OB, 2021, EUR NEUROPSYCHOPHARM, V51, P68, DOI 10.1016/j.euroneuro.2021.05.007
   Sneller MH, 2021, FRONT PSYCHIATRY, V12, DOI 10.3389/fpsyt.2021.625935
   Solmi F, 2019, BRIT J PSYCHIAT, V215, P428, DOI 10.1192/bjp.2019.39
   Tomasik J, 2019, JAMA PSYCHIAT, V76, P864, DOI 10.1001/jamapsychiatry.2019.0304
   Torkamani A, 2018, NAT REV GENET, V19, P581, DOI 10.1038/s41576-018-0018-x
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vassos E, 2017, BIOL PSYCHIAT, V81, P470, DOI 10.1016/j.biopsych.2016.06.028
   Vázquez-Bourgon J, 2020, EUR NEUROPSYCHOPHARM, V39, P46, DOI 10.1016/j.euroneuro.2020.08.009
   Wang SH, 2018, GENES BRAIN BEHAV, V17, P49, DOI 10.1111/gbb.12401
   Zhang JP, 2019, AM J PSYCHIAT, V176, P21, DOI 10.1176/appi.ajp.2018.17121363
   Zwicker A, 2018, J PSYCHIATR RES, V105, P17, DOI 10.1016/j.jpsychires.2018.08.011
NR 56
TC 13
Z9 13
U1 2
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD JUN
PY 2022
VL 244
BP 101
EP 110
DI 10.1016/j.schres.2022.05.021
EA MAY 2022
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 2A6PY
UT WOS:000809622900002
PM 35659654
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Antonino, C
   Vitale, E
   Bardone, L
AF Antonino, Calabro
   Vitale, Elsa
   Bardone, Lorenzo
TI Sex-Related Differences Linked to Depression Disorders and Chronic
   Inflammation Diseases in Nursing Shift Workers: An Expsloratory
   Multidimensional Literature Review
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Review
DE Depression; inflammation; sex; shift nurses; gender role; nursing;
   medicine; rheumatologically diseases
ID LOW-BACK-PAIN; CAUSE-SPECIFIC MORTALITY; C-REACTIVE PROTEIN; ITALIAN
   NURSES; METABOLIC SYNDROME; SLEEP DISTURBANCE; RISK-FACTORS; PREVALENCE;
   WORKING; GENDER
AB Objective The objective of this literature review is to explore how depression and inflammatory conditions relate to gender among nurses working shifts. Methods Relevant studies available on the PubMed database over the past decade were consulted. The main keywords were: "shift nurses", "depression", "gender Shift Nurses", "Gender Role", "shift nurse", "gender roles", "Inflammation" and then, free terms were combined with the Boolean AND operator. Inclusion and exclusion criteria had been formerly identified, and then, all the selected studies were assessed according to the following criteria, good description, and appropriateness of study design (objective and method), sample (sufficiently numerous, clarity of treatment allocation criteria, absence of important bias), intervention, outcomes, statistical analysis, and clinical relevance. Results 61 titles concerning research on inflammation were found. 28 titles were not taken into account as doubles whilst 33 were selected by title and abstract; in addition, 28 were discarded because they were not relevant to the objective or because they did not meet the inclusion criteria. Out of the remaining 5, a further 2 were also discarded upon a careful analysis of the whole text: they did not prove relevant to the research question. As for the research related to depression, the research strategy highlighted 186 articles in the first place and then eliminated 165 of them either because they were duplicates or on the grounds that they did not answer the research questions; 21 texts were thoroughly analyzed and, after a careful read, 4 studies were eventually incorporated in this review. Conclusion Since data available in the literature were inconsistent, it was difficult to establish that all depression conditions could be associated with an increase in inflammation and vice versa and that this condition was strictly connected to the female gender.
C1 [Antonino, Calabro] Nuovo Osped Infermi, Local Hlth Author Biella, Biella, Italy.
   [Vitale, Elsa] Local Hlth Co Bari, Ctr Mental Hlth, Bari, Italy.
   [Bardone, Lorenzo] Univ Piemonte Orientale, Biella Headquarters, Biella, Italy.
   [Vitale, Elsa] Via X Marzo 43, I-70026 Bari, Italy.
C3 University of Eastern Piedmont Amedeo Avogadro
RP Vitale, E (corresponding author), Local Hlth Co Bari, Ctr Mental Hlth, Bari, Italy.; Vitale, E (corresponding author), Via X Marzo 43, I-70026 Bari, Italy.
EM vitaleelsa@libero.it
RI Vitale, Elsa/D-8904-2018
OI Vitale, Elsa/0000-0002-9738-3479; Calabro, Antonino/0000-0003-2843-6693
CR Abolfotouh SM, 2015, INT ORTHOP, V39, P2439, DOI 10.1007/s00264-015-2900-x
   Ang SY, 2016, BIOMED RES INT, V2016, DOI 10.1155/2016/6960184
   Angerer P, 2017, DTSCH ARZTEBL INT, V114, P404, DOI 10.3238/arztebl.2017.0404
   [Anonymous], 2018, AG GENDER RIV INTERN, DOI [DOI 10.15167/2279-5057/AG2017.6.12.488, 10.15167/2279-5057/AG2017.6.12.488]
   [Anonymous], 2019, PLAN APPL DISSEMINAT
   Attar Suzan Mansour, 2014, BMC Res Notes, V7, P61, DOI 10.1186/1756-0500-7-61
   Baggio G, 2013, CLIN CHEM LAB MED, V51, P713, DOI 10.1515/cclm-2012-0849
   Bara AC, 2009, SCAND J WORK ENV HEA, V35, P361, DOI 10.5271/sjweh.1344
   Bejia I, 2005, JOINT BONE SPINE, V72, P254, DOI 10.1016/j.jbspin.2004.06.001
   Benros ME, 2014, AM J PSYCHIAT, V171, P218, DOI 10.1176/appi.ajp.2013.13010086
   Bjorvatn B, 2020, FRONT PUBLIC HEALTH, V8, DOI 10.3389/fpubh.2020.00415
   Booker LA, 2020, J SLEEP RES, V29, DOI 10.1111/jsr.12872
   Borkowski N, 2007, HEALTH CARE MANAGE R, V32, P160, DOI 10.1097/01.HMR.0000267793.47803.41
   Bowling NA, 2005, J APPL PSYCHOL, V90, P1044, DOI 10.1037/0021-9010.90.6.1044
   Brandford AA, 2016, WORKPLACE HEALTH SAF, V64, P488, DOI 10.1177/2165079916653415
   Bronder EC, 2014, J BLACK PSYCHOL, V40, P115, DOI 10.1177/0095798412474466
   Brown D, 2020, HEALTH PROMOT PRACT, V21, P496, DOI 10.1177/1524839919893361
   Cain SW, 2015, SCAND J WORK ENV HEA, V41, P288, DOI 10.5271/sjweh.3486
   Chan MF, 2009, J CLIN NURS, V18, P285, DOI 10.1111/j.1365-2702.2008.02583.x
   Chapman A, 2020, SSM-POPUL HLTH, V12, DOI 10.1016/j.ssmph.2020.100663
   Copertaro A., 2013, SHIFT NIGHT WORK RIS
   Costa G, 2003, OCCUP MED-OXFORD, V53, P83, DOI 10.1093/occmed/kqg045
   Costa G, 2010, SAF HEALTH WORK, V1, P112, DOI 10.5491/SHAW.2010.1.2.112
   Czarny P, 2018, PROG NEURO-PSYCHOPH, V80, P309, DOI 10.1016/j.pnpbp.2017.06.036
   Davila EP, 2010, DIABETES CARE, V33, P2390, DOI 10.2337/dc10-0681
   de la Fuente-solana EI, 2021, J CLIN NURS, V30, P207, DOI 10.1111/jocn.15541
   Depner CM, 2014, CURR DIABETES REP, V14, DOI 10.1007/s11892-014-0507-z
   Frick LR, 2013, CLIN DEV IMMUNOL, DOI 10.1155/2013/608654
   Galecki P, 2018, PSYCHIATR POL, V52, P437, DOI 10.12740/PP/76863
   Galecki P, 2018, PROG NEURO-PSYCHOPH, V80, P267, DOI 10.1016/j.pnpbp.2017.05.023
   Galizzi G, 2016, MEDITARI ACCOUNT RES, V24, P246, DOI 10.1108/MEDAR-09-2015-0062
   Goldsmith DR, 2016, MOL PSYCHIATR, V21, P1696, DOI 10.1038/mp.2016.3
   González-Parra S, 2019, ACTAS DERMO-SIFILOGR, V110, P12, DOI 10.1016/j.ad.2018.05.009
   Gu FY, 2015, AM J PREV MED, V48, P241, DOI 10.1016/j.amepre.2014.10.018
   Halaris A, 2017, CURR TOP BEHAV NEURO, V31, P45, DOI 10.1007/7854_2016_28
   Himmerich H, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00030
   Horn SR, 2018, BRAIN BEHAV IMMUN, V73, P85, DOI 10.1016/j.bbi.2018.06.016
   Irwin MR, 2016, BIOL PSYCHIAT, V80, P40, DOI 10.1016/j.biopsych.2015.05.014
   Kang MY, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0188019
   Karahan A, 2009, J ADV NURS, V65, P516, DOI 10.1111/j.1365-2648.2008.04905.x
   Karlsson B, 2005, SCAND J WORK ENV HEA, V31, P30, DOI 10.5271/sjweh.845
   Keller J, 2017, MOL PSYCHIATR, V22, P527, DOI 10.1038/mp.2016.120
   Kessler RC, 2013, ANNU REV PUBL HEALTH, V34, P119, DOI 10.1146/annurev-publhealth-031912-114409
   Korompeli A, 2013, NURS FORUM, V48, P45, DOI 10.1111/nuf.12005
   Kuehner C, 2017, LANCET PSYCHIAT, V4, P146, DOI 10.1016/S2215-0366(16)30263-2
   La Sala M, 2007, G Ital Med Lav Ergon, V29, P445
   Lee S, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-36402-3
   Liukkonen T, 2006, BIOL PSYCHIAT, V60, P825, DOI 10.1016/j.biopsych.2006.02.016
   Maeng SH, 2019, INT NEUROUROL J, V23, pS63, DOI 10.5213/inj.1938226.113
   Maes M, 2009, METAB BRAIN DIS, V24, P27, DOI 10.1007/s11011-008-9118-1
   Martins JT, 2009, REV LAT-AM ENFERM, V17, P52, DOI 10.1590/S0104-11692009000100009
   Menard C, 2017, NAT NEUROSCI, V20, P1752, DOI 10.1038/s41593-017-0010-3
   Moghaddam Hamideh Yazdi, 2018, Electron Physician, V10, P7205, DOI 10.19082/7205
   Moher D, 2009, J CLIN EPIDEMIOL, V62, P1006, DOI 10.1016/j.jclinepi.2009.06.005
   Moola S, 2008, Curationis, V31, P77
   Morrissette DA, 2013, CNS SPECTRUMS, V18, P42, DOI 10.1017/S109285291300076X
   Mosadeghrad AM, 2013, INT J HEALTH POLICY, V1, P169, DOI 10.15171/ijhpm.2013.30
   Nobis A, 2020, J CLIN MED, V9, DOI 10.3390/jcm9123793
   Ohler MC, 2010, CAN J NURS RES, V42, P66
   Osimo EF, 2020, BRAIN BEHAV IMMUN, V87, P901, DOI 10.1016/j.bbi.2020.02.010
   Oyane NMF, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0070228
   Pai JK, 2004, NEW ENGL J MED, V351, P2599, DOI 10.1056/NEJMoa040967
   Pariante CM, 2009, BRAIN BEHAV IMMUN, V23, P325, DOI 10.1016/j.bbi.2009.01.006
   Parkes K R, 1999, J Occup Health Psychol, V4, P256, DOI 10.1037/1076-8998.4.3.256
   Patel SR, 2014, INT J OBESITY, V38, P1159, DOI 10.1038/ijo.2014.13
   Perez-Caballero L, 2019, CELL TISSUE RES, V377, P107, DOI 10.1007/s00441-018-2978-8
   Pietroiusti A, 2010, OCCUP ENVIRON MED, V67, P54, DOI 10.1136/oem.2009.046797
   Poghosyan L, 2017, HEALTH CARE MANAGE R, V42, P162, DOI 10.1097/HMR.0000000000000094
   Puttonen S, 2011, CHRONOBIOL INT, V28, P528, DOI 10.3109/07420528.2011.580869
   Reinhardt ÉL, 2019, CHRONOBIOL INT, V36, P11, DOI 10.1080/07420528.2018.1515771
   Ridker PM, 2003, CIRCULATION, V107, P363, DOI 10.1161/01.CIR.0000053730.47739.3C
   Royal College of Physicians. R.C.o.N, 2012, Ward Rounds in Medicine: Principles for Best Practice
   Salmi M., 2017, J GEND SPECIF MED, V3, P89
   Siegmann EM, 2018, JAMA PSYCHIAT, V75, P577, DOI 10.1001/jamapsychiatry.2018.0190
   SKIPPER JK, 1990, J ADV NURS, V15, P835, DOI 10.1111/j.1365-2648.1990.tb01915.x
   Slavish DC, 2020, PSYCHOSOM MED, V82, P678, DOI 10.1097/PSY.0000000000000843
   Sobstad J.H., 2020, HEALTH CARE MANAGE R
   Song BM, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2014-006429
   Sookoian S, 2007, J INTERN MED, V261, P285, DOI 10.1111/j.1365-2796.2007.01766.x
   STUBBS DA, 1986, INT J NURS STUD, V23, P325, DOI 10.1016/0020-7489(86)90055-6
   Suzuki E, 2010, J NURS MANAGE, V18, P194, DOI 10.1111/j.1365-2834.2010.01054.x
   Uchida S, 2018, PSYCHIAT CLIN NEUROS, V72, P212, DOI 10.1111/pcn.12621
   Vahedian-Azimi A, 2019, J INTENSIVE CARE MED, V34, P311, DOI 10.1177/0885066617696853
   Vitale E, 2022, ENDOCR METAB IMMUNE, V22, P490, DOI 10.2174/1871530321666210715125939
   Vitale E, 2021, J EVID-BASED PSYCHOT, V21, P83
   Vitale Elsa, 2021, Acta Biomed, V92, pe2021007, DOI 10.23750/abm.v92iS2.11305
   Vitale E, 2020, MINERVA PSICH, V61, P162, DOI 10.23736/S0391-1772.20.02090-7
   Vitale E, 2021, ENDOCR METAB IMMUNE, V21, P1604, DOI 10.2174/1871530320666201016150033
   Walker WH II, 2020, TRANSL PSYCHIAT, V10, DOI 10.1038/s41398-020-0694-0
   Williams DR, 2007, ARCH GEN PSYCHIAT, V64, P305, DOI 10.1001/archpsyc.64.3.305
   World Health Organization, 2008, US
   Xian MT, 2020, J CLIN NURS, V29, P535, DOI 10.1111/jocn.15103
   Yang LL, 2020, EUR NEUROPSYCHOPHARM, V41, P118, DOI 10.1016/j.euroneuro.2020.10.005
NR 93
TC 3
Z9 3
U1 0
U2 0
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2022
VL 22
IS 13
BP 1293
EP 1302
DI 10.2174/1871530322666220620101323
PG 10
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA 7A9MU
UT WOS:000898771900007
PM 35726431
DA 2025-06-11
ER

PT J
AU Nicholson, T
   Church, C
   Tsintzas, K
   Jones, R
   Breen, L
   Davis, ET
   Baker, DJ
   Jones, SW
AF Nicholson, Thomas
   Church, Chris
   Tsintzas, Kostas
   Jones, Robert
   Breen, Leigh
   Davis, Edward T.
   Baker, David J.
   Jones, Simon W.
TI Vaspin promotes insulin sensitivity in elderly muscle and is upregulated
   in obesity
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
DE skeletal muscle; adipokines; insulin; obesity; myotubes; adipose tissue
ID ADIPOSE-TISSUE MACROPHAGES; GLUT4 EXPRESSION; SKELETAL-MUSCLE;
   GLUCOSE-UPTAKE; METABOLIC SYNDROME; GENE-EXPRESSION; SEX-DIFFERENCES;
   SERUM-LEVELS; ER STRESS; P38 MAPK
AB Adipokines have emerged as central mediators of insulin sensitivity and metabolism, in part due to the known association of obesity with metabolic syndrome disorders such as type 2 diabetes. Recent studies in rodents have identified the novel adipokine vaspin as playing a protective role in inflammatory metabolic diseases by functioning as a promoter of insulin sensitivity during metabolic stress. However, at present the skeletal muscle and adipose tissue expression of vaspin in humans is poorly characterised. Furthermore, the functional role of vaspin in skeletal muscle insulin sensitivity has not been studied. Since skeletal muscle is the major tissue for insulin-stimulated glucose uptake, understanding the functional role of vaspin in human muscle insulin signalling is critical in determining its role in glucose homeostasis. The objective of this study was to profile the skeletal muscle and subcutaneous adipose tissue expression of vaspin in humans of varying adiposity, and to determine the functional role of vaspin in mediating insulin signalling and glucose uptake in human skeletal muscle. Our data shows that vaspin is secreted from both human subcutaneous adipose tissue and skeletal muscle, and is more highly expressed in obese older individuals compared to lean older individuals. Furthermore, we demonstrate that vaspin induces activation of the PI3K/AKT axis, independent of insulin receptor activation, promotes GLUT4 expression and translocation and sensitises older obese human skeletal muscle to insulin-mediated glucose uptake.
C1 [Nicholson, Thomas; Breen, Leigh; Jones, Simon W.] Univ Birmingham, MRC ARUK Ctr Musculoskeletal Ageing Res, Inst Inflammat & Ageing, Birmingham, W Midlands, England.
   [Church, Chris; Baker, David J.] MedImmune, Cardiovasc & Metab Dis CVMD, Milstein Bldg, Cambridge, England.
   [Tsintzas, Kostas; Jones, Robert] Univ Nottingham, MRC ARUK Ctr Musculoskeletal Ageing Res, Fac Med & Hlth Sci, Sch Life Sci, Nottingham, England.
   [Davis, Edward T.] Royal Orthopaed Hosp NHS Fdn Trust, Birmingham, W Midlands, England.
C3 University of Birmingham; AstraZeneca; Medimmune; University of
   Nottingham; Royal Orthopaedic Hospital
RP Jones, SW (corresponding author), Univ Birmingham, MRC ARUK Ctr Musculoskeletal Ageing Res, Inst Inflammat & Ageing, Birmingham, W Midlands, England.
EM S.W.Jones@bham.ac.uk
RI Jones, Simon/ABB-8625-2020; Breen, Leigh/AAO-7302-2021
OI Breen, Leigh/0000-0001-6669-4816; Jones, Simon/0000-0001-6785-2310
FU BBSRC; MedImmune/AstraZeneca [BB/N504002/1]; BBSRC [1733068] Funding
   Source: UKRI; MRC [MR/P021220/1] Funding Source: UKRI
FX T N was funded by a BBSRC Case PhD studentship with
   MedImmune/AstraZeneca (BB/N504002/1).
CR Aas V, 2004, DIABETOLOGIA, V47, P1452, DOI 10.1007/s00125-004-1465-9
   Al-Khalili L, 2003, CELL MOL LIFE SCI, V60, P991, DOI 10.1007/s00018-003-3001-3
   [Anonymous], 2011, OBESITY, DOI DOI 10.1038/oby.2010.123
   Aust G, 2009, ATHEROSCLEROSIS, V204, P262, DOI 10.1016/j.atherosclerosis.2008.08.028
   Beigh SH, 2012, BIOINFORMATION, V8, P613, DOI 10.6026/97320630008613
   Blaber SP, 2012, J TRANSL MED, V10, DOI 10.1186/1479-5876-10-172
   Blüher M, 2015, METABOLISM, V64, P131, DOI 10.1016/j.metabol.2014.10.016
   Blüher M, 2014, MOL METAB, V3, P230, DOI 10.1016/j.molmet.2014.01.005
   Carey DG, 1996, DIABETES, V45, P633, DOI 10.2337/diabetes.45.5.633
   Chowdhury HH, 2005, PFLUG ARCH EUR J PHY, V450, P131, DOI 10.1007/s00424-004-1378-y
   dos Santos JM, 2012, CELL BIOCHEM FUNCT, V30, P191, DOI 10.1002/cbf.1834
   Dugani CB, 2005, EMBO REP, V6, P1137, DOI 10.1038/sj.embor.7400584
   Edgar R, 2002, NUCLEIC ACIDS RES, V30, P207, DOI 10.1093/nar/30.1.207
   Esteghamati A, 2014, DIABETES METAB J, V38, P143, DOI 10.4093/dmj.2014.38.2.143
   Fuente-Martín E, 2013, ADIPOCYTE, V2, P128, DOI 10.4161/adip.24075
   Heiker JT, 2013, CELL MOL LIFE SCI, V70, P2569, DOI 10.1007/s00018-013-1258-8
   Hida K, 2005, P NATL ACAD SCI USA, V102, P10610, DOI 10.1073/pnas.0504703102
   Hida K, 2000, J LIPID RES, V41, P1615
   Holliday KL, 2011, OSTEOARTHR CARTILAGE, V19, P37, DOI 10.1016/j.joca.2010.10.014
   Ibrahim DM, 2018, OBES SURG, V28, P3237, DOI 10.1007/s11695-018-3306-9
   Jensen EB, 2009, AM J PHYSIOL-REG I, V296, pR1820, DOI 10.1152/ajpregu.90651.2008
   Jian WX, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094763
   KAHN BB, 1993, ENDOCRINOLOGY, V132, P13, DOI 10.1210/en.132.1.13
   Kahn BB, 2000, J CLIN INVEST, V106, P473, DOI 10.1172/JCI10842
   Kalyani RR, 2017, DIABETES CARE, V40, P440, DOI 10.2337/dci17-0005
   Kawasaki N, 2012, SCI REP-UK, V2, DOI 10.1038/srep00799
   Khadir A, 2016, METABOLISM, V65, P1409, DOI 10.1016/j.metabol.2016.06.004
   Klöting N, 2006, BIOCHEM BIOPH RES CO, V339, P430, DOI 10.1016/j.bbrc.2005.11.039
   Koshy Shyny, 2010, J Vis Exp, DOI 10.3791/2429
   KOTANI K, 1994, INT J OBESITY, V18, P207
   Lee AS, 2005, METHODS, V35, P373, DOI 10.1016/j.ymeth.2004.10.010
   Lehr S, 2012, MOL CELL PROTEOMICS, V11, DOI 10.1074/mcp.M111.010504
   Li C, 2006, INT J OBESITY, V30, P1775, DOI 10.1038/sj.ijo.0803339
   Liu P, 2015, EXP BIOL MED, V240, P1520, DOI 10.1177/1535370214565081
   Liu SW, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-31923-3
   Liu SW, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0189722
   Maria Z, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0146033
   Matsuo K, 2013, GYNECOL ONCOL, V128, P552, DOI 10.1016/j.ygyno.2012.11.024
   Mcgee SL, 2008, DIABETES, V57, P860, DOI 10.2337/db07-0843
   Montell E, 2001, AM J PHYSIOL-ENDOC M, V280, pE229, DOI 10.1152/ajpendo.2001.280.2.E229
   Montessuit C, 2004, CARDIOVASC RES, V64, P94, DOI 10.1016/j.cardiores.2004.06.005
   Nakatsuka A, 2012, DIABETES, V61, P2823, DOI 10.2337/db12-0232
   Nicholson T, 2018, J INFLAMM-LOND, V15, DOI 10.1186/s12950-018-0185-8
   Niu WY, 2003, J BIOL CHEM, V278, P17953, DOI 10.1074/jbc.M211136200
   O'Leary MF, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-13479-w
   Pellegrinelli V, 2015, DIABETES, V64, P3121, DOI 10.2337/db14-0796
   PRATLEY RE, 1995, AM J PHYSIOL-ENDOC M, V268, pE484, DOI 10.1152/ajpendo.1995.268.3.E484
   Rosqvist F, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0445-2
   Rossi AP, 2011, J GERONTOL A-BIOL, V66, P801, DOI [10.1093/gerona/glr058, 10.1093/gerona/glr059]
   Seeger J, 2008, J CLIN ENDOCR METAB, V93, P247, DOI 10.1210/jc.2007-1853
   Skurk T, 2007, J CLIN ENDOCR METAB, V92, P1023, DOI 10.1210/jc.2006-1055
   Sun N, 2015, INT J CLIN EXP PATHO, V8, P482
   Teshigawara S, 2012, J CLIN ENDOCR METAB, V97, pE1202, DOI 10.1210/jc.2011-3297
   THIEBAUD D, 1982, DIABETES, V31, P957, DOI 10.2337/diacare.31.11.957
   Tilg H, 2006, NAT REV IMMUNOL, V6, P772, DOI 10.1038/nri1937
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Wentworth JM, 2010, DIABETES, V59, P1648, DOI 10.2337/db09-0287
   White UA, 2014, BBA-MOL BASIS DIS, V1842, P377, DOI 10.1016/j.bbadis.2013.05.006
   Yilmaz E, 2017, ADV EXP MED BIOL, V960, P261, DOI 10.1007/978-3-319-48382-5_11
   You BS, 2008, DIABETES, V57, P372, DOI 10.2337/db07-1045
   Zeyda M, 2007, INT J OBESITY, V31, P1420, DOI 10.1038/sj.ijo.0803632
   Zeyda M, 2007, IMMUNOL LETT, V112, P61, DOI 10.1016/j.imlet.2007.07.003
   Zhang Y, 2010, J BIOL CHEM, V285, P15065, DOI 10.1074/jbc.M109.087445
NR 63
TC 35
Z9 36
U1 0
U2 5
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD APR
PY 2019
VL 241
IS 1
BP 31
EP 43
DI 10.1530/JOE-18-0528
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HN6QD
UT WOS:000460309900004
PM 30721136
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Meepring, S
   Chien, WT
   Gray, R
   Bressington, D
AF Meepring, Soontareeporn
   Chien, Wai Tong
   Gray, Richard
   Bressington, Daniel
TI Effects of the Thai Health Improvement Profile intervention on the
   physical health and health behaviours of people with schizophrenia: A
   quasi-experimental study
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE BMI; health behaviours; physical health; schizophrenia; severe mental
   illness
ID SERIOUS MENTAL-ILLNESS; METABOLIC SYNDROME; WEIGHT-GAIN; DRUG-NAIVE;
   PREVALENCE; METAANALYSIS; 1ST-EPISODE; MORTALITY; CRITERIA; PROGRAM
AB Physical health problems and unhealthy lifestyle behaviours are common in people with severe mental illness (SMI), leading to high levels of mortality.There is some evidence that nurse-led interventions involving comprehensive health checks may be effective in improving physical health in people with SMI. This quasi-experimental before-and-after study investigated the impacts of the Thai Health Improvement Profile (HIP-T) on the physical health and health behaviours of people with schizophrenia over 1-year. All 105 service-users who volunteered to participate completed the study. There were significant reductions in mean BMI (-0.78kg/m(2), P<.001) and bodyweight (-1.13kg, P<.001) at post-test. There was also a significant decrease in the total number of red-flagged HIP-T items, suggesting lowered potential health risks (P<.001). Overall, 23 patients (22%) were found to have moved to a healthier BMI classification after 1-year. The findings suggest that the HIP-T intervention has potential for improving the physical health of people with SMI when integrated into routine community mental health care.
C1 [Meepring, Soontareeporn] Naresuan Univ, Mental Hlth & Psychiat Nursing Div, Dept Nursing, Phitsanulok, Thailand.
   [Chien, Wai Tong; Bressington, Daniel] Hong Kong Polytech Univ, Mental Hlth Care Res Grp, Sch Nursing, Hong Kong, Hong Kong, Peoples R China.
   [Gray, Richard] Hamad Med Corp, Hlth Serv Res Ctr, Doha, Qatar.
   [Gray, Richard] La Trobe Univ, Dept Nursing, Melbourne, Vic, Australia.
C3 Naresuan University; Hong Kong Polytechnic University; Hamad Medical
   Corporation; La Trobe University
RP Bressington, D (corresponding author), Hong Kong Polytech Univ, Sch Nursing, Kowloon, Hong Kong, Peoples R China.
EM dan.bressington@polyu.edu.hk
RI Gray, Richard/C-9945-2017; Chien, Wai Tong/M-6106-2019; Bressington,
   Daniel/G-2789-2017; Chien, Wai Tong/F-9604-2014
OI Bressington, Daniel/0000-0003-0951-2208; Meepring, Thongsai,
   Soontareeporn/0000-0001-5648-2908; Chien, Wai Tong/0000-0001-5321-5791
CR Aekplakorn W, 2011, ASIA-PAC J PUBLIC HE, V23, P792, DOI 10.1177/1010539511424482
   Alvarez-Jiménez M, 2006, J CLIN PSYCHIAT, V67, P1253, DOI 10.4088/JCP.v67n0812
   Anderson S., 2016, J MENTAL HLTH
   [Anonymous], 2006, THE IDF CONSENSUS WO
   Bankston CL III, 2006, NEW DIR CHILD ADOLES, V114, P25, DOI 10.1002/cad.173
   Barnes TRE, 2008, ACTA PSYCHIAT SCAND, V118, P26, DOI 10.1111/j.1600-0447.2008.01203.x
   Bonfioli E, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-78
   Bressington D, 2016, INT J MENT HEALTH NU, V25, P214, DOI 10.1111/inm.12195
   Bressington D, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/1471-244X-14-57
   Bressington DT, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-87
   Chow SC, 2011, WIRES COMPUT STAT, V3, P414, DOI 10.1002/wics.155
   Clayton AH, 2009, J SEX MED, V6, P1200, DOI 10.1111/j.1743-6109.2009.01255.x
   COHEN J, 1992, PSYCHOL BULL, V112, P155, DOI 10.1037/0033-2909.112.1.155
   Cohen J., 1988, STAT POWER ANAL BEHA, DOI [10.4324/9780203771587, DOI 10.4324/9780203771587]
   Colton Craig W, 2006, Prev Chronic Dis, V3, pA42
   Curtis J, 2016, EARLY INTERV PSYCHIA, V10, P267, DOI 10.1111/eip.12230
   De Hert M, 2011, BRIT J PSYCHIAT, V199, P99, DOI 10.1192/bjp.bp.110.084665
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   De Hert M, 2009, WORLD PSYCHIATRY, V8, P15
   Eldridge D, 2011, BMC PSYCHIATRY, V11, DOI 10.1186/1471-244X-11-46
   Fields LE, 2004, HYPERTENSION, V44, P398, DOI 10.1161/01.HYP.0000142248.54761.56
   Foley DL, 2011, ARCH GEN PSYCHIAT, V68, P609, DOI 10.1001/archgenpsychiatry.2011.2
   Gubbins A, 2012, PSYCHIATR BULL, V36, P326, DOI 10.1192/pb.bp.111.037374
   Happell B, 2011, J PSYCHIATR MENT HLT, V18, P706, DOI 10.1111/j.1365-2850.2010.01666.x
   Happell B, 2012, INT J MENT HEALTH NU, V21, P236, DOI 10.1111/j.1447-0349.2012.00816.x
   Jorgensen R, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/1471-244X-14-28
   Kanazawa M, 2005, WORLD REV NUTR DIET, V94, P1, DOI 10.1159/000088200
   Lack D, 2015, THER ADV PSYCHOPHARM, V5, P22, DOI 10.1177/2045125314560734
   Littrell KH, 2003, J NURS SCHOLARSHIP, V35, P237, DOI 10.1111/j.1547-5069.2003.00237.x
   McEvoy JP, 2005, SCHIZOPHR RES, V80, P19, DOI 10.1016/j.schres.2005.07.014
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Moyers TB, 2002, J CLIN PSYCHOL, V58, P185, DOI 10.1002/jclp.1142
   National Institute for Clinical Excellence, 2014, 178 NICE
   Ohlsen R I, 2005, J Psychiatr Ment Health Nurs, V12, P614
   Ösby U, 2000, SCHIZOPHR RES, V45, P21, DOI 10.1016/S0920-9964(99)00191-7
   Robson D, 2007, INT J NURS STUD, V44, P457, DOI 10.1016/j.ijnurstu.2006.07.013
   Roshanaei-Moghaddam B, 2009, PSYCHIAT SERV, V60, P147, DOI 10.1176/appi.ps.60.2.147
   Shuel F, 2010, INT J NURS STUD, V47, P136, DOI 10.1016/j.ijnurstu.2009.06.003
   Stubbs B, 2015, ACTA PSYCHIAT SCAND, V132, P144, DOI 10.1111/acps.12439
   Suttajit S, 2013, NEUROPSYCH DIS TREAT, V9, P941, DOI 10.2147/NDT.S47450
   Thongsai S, 2016, J PSYCHIATR MENT HLT, V23, P255, DOI 10.1111/jpm.12300
   van Meijel B, 2015, PERSPECT PSYCHIATR C, V51, P106, DOI 10.1111/ppc.12071
   Vancampfort D, 2013, WORLD PSYCHIATRY, V12, P240, DOI 10.1002/wps.20069
   Villeneuve K, 2010, SCHIZOPHR RES, V121, P266, DOI 10.1016/j.schres.2010.04.003
   von Hausswolff-Juhlin Y, 2009, ACTA PSYCHIAT SCAND, V119, P15, DOI 10.1111/j.1600-0447.2008.01309.x
   Vreeland B, 2003, PSYCHIAT SERV, V54, P1155, DOI 10.1176/appi.ps.54.8.1155
   White J, 2009, J PSYCHIATR MENT HLT, V16, P493, DOI 10.1111/j.1365-2850.2009.01375.x
   White J, 2011, TRIALS, V12, DOI 10.1186/1745-6215-12-167
   Zullino D, 2003, CAN J PSYCHIAT, V48, P480, DOI 10.1177/070674370304800709
NR 49
TC 13
Z9 14
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD FEB
PY 2018
VL 27
IS 1
BP 126
EP 137
DI 10.1111/inm.12301
PG 12
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA FS3XF
UT WOS:000419717100012
PM 27982537
DA 2025-06-11
ER

PT J
AU Yang, XY
   Feng, C
   Feng, JP
AF Yang, Xueyuan
   Feng, Chao
   Feng, Jinping
TI Epicardial Adipose Tissue and Diabetic Cardiomyopathy
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
LA English
DT Review
DE diabetic cardiomyopathy; epicardial adipose tissue; insulin resistance;
   oxidative stress; autophagy
ID BINDING-PROTEIN 4; CORONARY-ARTERY-DISEASE; LOW-DENSITY-LIPOPROTEIN;
   INSULIN-RESISTANCE; MACROPHAGE POLARIZATION; CARDIAC DYSFUNCTION;
   METABOLIC SYNDROME; SIGNALING PATHWAY; HEART-FAILURE; FAT
AB Diabetes is a long-term chronic disease, and cardiovascular disease is the leading cause of death. Diabetic cardiomyopathy (DCM), one of the cardiovascular complications of diabetes, has many uncertain factors. Epicardial fat, as the heart fat bank, functions as fatty tissue and is the heart's endocrine organ. The existence of diabetes affects the distribution of heart fat and promotes the secretion of adipokine. In different pathological conditions, it can promote the secretion of pro-inflammatory adipokine, reactive oxygen species, oxidative stress, and even autophagy, thus affecting cardiac function. In this paper, we will elaborate on the mechanism of epicardial fat in the pathogenesis of diabetic cardiomyopathy.
C1 [Yang, Xueyuan] Tianjin Med Univ, Chest Clin Coll, Tianjin, Peoples R China.
   [Feng, Chao; Feng, Jinping] Tianjin Chest Hosp, Tianjin, Peoples R China.
   [Feng, Jinping] Tianjin Chest Hosp, Tianjin 300222, Peoples R China.
C3 Tianjin Medical University
RP Feng, JP (corresponding author), Tianjin Chest Hosp, Tianjin 300222, Peoples R China.
EM chlfjp@sina.com
CR Abad-Jiménez Z, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9090892
   An Y, 2021, AM J TRANSL RES, V13, P6305
   Antonopoulos AS, 2016, CIRC RES, V118, P842, DOI 10.1161/CIRCRESAHA.115.307856
   Arow M, 2020, CARDIOVASC DIABETOL, V19, DOI 10.1186/s12933-019-0980-4
   Bambace C, 2014, HEART VESSELS, V29, P42, DOI 10.1007/s00380-012-0315-9
   Barber MC, 2000, J ANIM SCI, V78, P62
   Blumensatt M, 2017, BASIC RES CARDIOL, V112, DOI 10.1007/s00395-016-0591-0
   Bublitz K, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9102298
   Cairo M, 2020, J PHYSIOL BIOCHEM, V76, P213, DOI 10.1007/s13105-019-00708-1
   Chauhan A., 2021, J ASS PHYS INDIA, V69, P11
   Colom C, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0794-9
   D'Imperio S, 2021, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.688875
   Dewanjee S, 2021, AGEING RES REV, V68, DOI 10.1016/j.arr.2021.101338
   Díaz-Rodríguez E, 2018, CARDIOVASC RES, V114, P336, DOI 10.1093/cvr/cvx186
   Dinescu S, 2021, ADV EXP MED BIOL, V1312, P139, DOI 10.1007/5584_2020_588
   Du X, 2018, CELL DEATH DIS, V9, DOI 10.1038/s41419-017-0205-2
   Elisha B, 2016, HORM METAB RES, V48, P42, DOI 10.1055/s-0035-1554688
   Farias-Itao DS, 2016, JMIR RES PROTOC, V5, DOI 10.2196/resprot.6340
   Ferhat M, 2019, ANTIOXID REDOX SIGN, V31, P487, DOI 10.1089/ars.2018.7626
   Fernández-Trasancos A, 2016, J CELL PHYSIOL, V231, P1015, DOI 10.1002/jcp.25189
   Gaborit B, 2022, DIABETES OBES METAB, V24, P578, DOI 10.1111/dom.14595
   Gastaldelli A, 2012, CURR OPIN CLIN NUTR, V15, P523, DOI 10.1097/MCO.0b013e328358be7b
   Greulich S, 2011, J CELL MOL MED, V15, P2399, DOI 10.1111/j.1582-4934.2010.01232.x
   Rotkvic PG, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22115973
   Gruzdeva OV, 2022, J PERS MED, V12, DOI 10.3390/jpm12020129
   Guay C, 2015, CELL COMMUN SIGNAL, V13, DOI 10.1186/s12964-015-0097-7
   Günes H, 2020, CARDIOL YOUNG, V30, P1429, DOI 10.1017/S1047951120002103
   Günes H, 2020, ARQ BRAS CARDIOL, V114, P675, DOI 10.36660/abc.20190197
   Gurses KM, 2017, J CARDIOL, V69, P851, DOI 10.1016/j.jjcc.2016.08.016
   He SY, 2020, BIOCHEM BIOPH RES CO, V525, P334, DOI 10.1016/j.bbrc.2020.02.053
   Hirata Y, 2011, J AM COLL CARDIOL, V58, P248, DOI 10.1016/j.jacc.2011.01.048
   Hirata Y, 2011, INT HEART J, V52, P139, DOI 10.1536/ihj.52.139
   Hu JQ, 2018, BBA-MOL BASIS DIS, V1864, P3639, DOI 10.1016/j.bbadis.2018.08.026
   Huang WH, 2020, EUR REV MED PHARMACO, V24, P7002, DOI 10.26355/eurrev_202006_21693
   Iacobellis G, 2022, J ENDOCRINOL INVEST, V45, P489, DOI 10.1007/s40618-021-01687-1
   Iacobellis G, 2014, NUTR METAB CARDIOVAS, V24, P725, DOI 10.1016/j.numecd.2013.11.001
   Iacobellis G, 2011, TRENDS ENDOCRIN MET, V22, P450, DOI 10.1016/j.tem.2011.07.003
   Jia GH, 2018, CIRC RES, V122, P624, DOI 10.1161/CIRCRESAHA.117.311586
   Kaspi H, 2014, TRENDS ENDOCRIN MET, V25, P285, DOI 10.1016/j.tem.2014.01.003
   Khan S, 2021, ENDOCR METAB IMMUNE, V21, P268, DOI 10.2174/1871530320666200731174724
   Kobayashi S, 2015, BBA-MOL BASIS DIS, V1852, P252, DOI 10.1016/j.bbadis.2014.05.020
   Koepp KE, 2020, JACC-HEART FAIL, V8, P657, DOI 10.1016/j.jchf.2020.04.016
   Li B, 2020, J CELL MOL MED, V24, P7751, DOI 10.1111/jcmm.15407
   Li DY, 2003, J AM COLL CARDIOL, V41, P1048, DOI 10.1016/S0735-1097(02)02966-2
   Li YR, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0807-3
   Malavazos AE, 2010, AM J CARDIOL, V105, P1831, DOI 10.1016/j.amjcard.2010.01.368
   Martín-Fuentes P, 2007, J IMMUNOL, V179, P3242, DOI 10.4049/jimmunol.179.5.3242
   Meisinger C, 2011, DIABETES CARE, V34, P1648, DOI 10.2337/dc11-0118
   Momesso DP, 2011, DIABETES RES CLIN PR, V91, P47, DOI 10.1016/j.diabres.2010.09.037
   Moraes-Vieira PM, 2020, P NATL ACAD SCI USA, V117, P31309, DOI 10.1073/pnas.2013877117
   Nakajima T, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-40419-7
   Nankam PAN, 2021, MOL CELL ENDOCRINOL, V531, DOI 10.1016/j.mce.2021.111312
   Naryzhnaya NV, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9010064
   Packer M, 2018, CIRCULATION, V137, P1614, DOI 10.1161/CIRCULATIONAHA.117.032474
   Pate VB, 2016, DIABETES, V65, P85, DOI 10.2337/db15-0399
   Patel VB, 2016, ADIPOCYTE, V5, P306, DOI 10.1080/21623945.2015.1131881
   Perumalsamy S, 2021, BIOLOGY-BASEL, V10, DOI 10.3390/biology10090858
   Polonsky KS, 2006, NEW ENGL J MED, V354, P2596, DOI 10.1056/NEJMe068091
   Prakaschandra RD, 2018, J CARDIOVASC ECHOGR, V28, P160, DOI 10.4103/jcecho.jcecho_71_17
   Qi QB, 2007, J CLIN ENDOCR METAB, V92, P4827, DOI 10.1210/jc.2007-1219
   Roever L, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000010387
   Roubícek T, 2008, PHYSIOL RES, V57, P911, DOI 10.33549/physiolres.931315
   Sacks HS, 2007, AM HEART J, V153, P907, DOI 10.1016/j.ahj.2007.03.019
   Sacks HS, 2009, J CLIN ENDOCR METAB, V94, P3611, DOI 10.1210/jc.2009-0571
   Salgado-Somoza A, 2012, CLIN ENDOCRINOL, V76, P51, DOI 10.1111/j.1365-2265.2011.04140.x
   Salgado-Somoza A, 2010, AM J PHYSIOL-HEART C, V299, pH202, DOI 10.1152/ajpheart.00120.2010
   Salvatore T, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.695792
   Santiago-Fernández C, 2019, J TRANSL MED, V17, DOI 10.1186/s12967-019-1842-2
   Sena CM, 2019, REV PORT CARDIOL, V38, P425, DOI 10.1016/j.repc.2019.07.001
   Shaihov-Teper O, 2021, CIRCULATION, V143, P2475, DOI 10.1161/CIRCULATIONAHA.120.052009
   Smith U, 2016, J INTERN MED, V280, P465, DOI 10.1111/joim.12540
   Sukumaran V, 2022, PFLUG ARCH EUR J PHY, V474, P63, DOI 10.1007/s00424-021-02651-x
   Svanteson M, 2019, CARDIOVASC DIABETOL, V18, DOI 10.1186/s12933-019-0861-x
   Tedford RJ, 2020, JACC-HEART FAIL, V8, P677, DOI 10.1016/j.jchf.2020.04.018
   Thankam FG, 2022, J TISSUE ENG REGEN M, V16, P396, DOI 10.1002/term.3289
   Vianello E, 2016, NUTR METAB CARDIOVAS, V26, P246, DOI 10.1016/j.numecd.2015.12.005
   Fricke ACV, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20235989
   Vyas V, 2021, JCI INSIGHT, V6, DOI 10.1172/jci.insight.145495
   Wang XH, 2016, DIABETES, V65, P3111, DOI 10.2337/db15-1563
   Wang YL, 2021, J HEALTHC ENG, V2021, DOI 10.1155/2021/8476592
   Wen ZY, 2020, OBESITY, V28, P1932, DOI 10.1002/oby.22932
   Yamamuro T, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-17985-w
   Yan Z., 2019, ADV CARDIOVASC DIS, V40, P618
   Yazici D, 2011, ENDOCRINE, V40, P250, DOI 10.1007/s12020-011-9478-x
   Zhao Na, 2021, J Diabetes Res, V2021, P5578216, DOI 10.1155/2021/5578216
   Zhou MM, 2020, PACE, V43, P133, DOI 10.1111/pace.13825
   Zobel EH, 2020, CARDIOVASC DIABETOL, V19, DOI 10.1186/s12933-020-0995-x
NR 87
TC 7
Z9 7
U1 2
U2 10
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1074-2484
EI 1940-4034
J9 J CARDIOVASC PHARM T
JI J. Cardiovasc. Pharmacol. Ther.
PY 2023
VL 28
AR 10742484231151820
DI 10.1177/10742484231151820
PG 10
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 8W4GL
UT WOS:000931293400001
PM 36752345
OA gold
DA 2025-06-11
ER

PT J
AU Ilincic, B
   Stokic, E
   Stosic, Z
   Kojic, NE
   Katsiki, N
   Mikhailidis, DP
   Isenovic, ER
AF Ilincic, Branislava
   Stokic, Edita
   Stosic, Zoran
   Kojic, Nevena Eremic
   Katsiki, Niki
   Mikhailidis, Dimitri P.
   Isenovic, Esma R.
TI Vitamin D status and circulating biomarkers of endothelial dysfunction
   and inflammation in non-diabetic obese individuals: a pilot study
SO ARCHIVES OF MEDICAL SCIENCE
LA English
DT Article
DE vitamin D; endothelial dysfunction; inflammation; obesity;
   cardiometabolic risk factors
ID C-REACTIVE PROTEIN; CARDIOVASCULAR RISK; OXIDATIVE STRESS; D DEFICIENCY;
   CELLS; METAANALYSIS; MECHANISMS; GLUCOSE; MARKERS; WEIGHT
AB Introduction: Obesity and inadequate vitamin D status are associated with endothelial dysfunction and cardiovascular disease. We evaluated the associations between vitamin D status (i.e. serum levels of 25-hydroxyvitamin D (25(OH)D)), biomarkers of endothelial dysfunction (i.e. serum concentrations of soluble intercellular adhesion molecule 1 (sICAM-1) and soluble E-selectin (sE-selectin)), inflammatory markers (i.e. high-sensitivity C-reactive protein (hsCRP) and fibrinogen) and cardiometabolic risk factors.
   Material and methods: Fifty obese (body mass index (BMI) >= 30 kg/m(2)) non-diabetic adults (mean age: 36.2 +/- 5.4 years) without pre-existing cardiovascular abnormalities and 25 clinically healthy, normal weight and age matched individuals were included. Anthropometric parameters, markers of glucose and lipid metabolism, and serum levels of inflammatory and endothelial dysfunction biomarkers were assessed in all subjects.
   Results: The mean serum 25(OH)D level was significantly lower in the obese group than in controls (33.5 +/- 15.2 vs. 60.1 +/- 23.1 nmol/l; p < 0.001). In the obese group, sE-selectin (36.4 (32.1-47.2) vs. 32.4 (24.6-35.5) ng/ml, p < 0.05) and hsCRP (6.0 +/- 3.4 vs. 3.5 1.0 mg/l, p < 0.05) were significantly higher in individuals with lower than median vitamin D levels (i.e. 31 nmol/l) compared with those with higher vitamin D levels. In multivariable linear regression analysis, hsCRP (beta = 0.43; p < 0.001) and sE-selectin (beta = 0.30; p = 0.03) were independently and significantly associated with serum 25(OH)D levels in the obese group.
   Conclusions: Vitamin D levels may be related to increased levels of biomarkers of endothelial dysfunction and inflammation in obese non-diabetic individuals.
C1 [Ilincic, Branislava; Stokic, Edita; Stosic, Zoran; Kojic, Nevena Eremic] Univ Novi Sad, Clin Ctr Vojvodina, Fac Med, Novi Sad, Serbia.
   [Katsiki, Niki] Aristotle Univ Thessaloniki, Sch Med, Propedeut Dept Internal Med 2, Hippokrat Hosp, Thessaloniki, Greece.
   [Mikhailidis, Dimitri P.] UCL, Sch Med, Dept Clin Biochem, Vasc Dis Prevent Clin, Royal Free Hosp Campus, London, England.
   [Isenovic, Esma R.] Univ Belgrade, Inst Vinca, Lab Mol Genet & Radiobiol, Belgrade, Serbia.
C3 University of Novi Sad; Aristotle University of Thessaloniki; University
   of London; University College London; UCL Medical School; Royal Free
   London NHS Foundation Trust; University of Belgrade
RP Ilincic, B (corresponding author), Univ Novi Sad, Fac Med, Dept Pathophysiol & Lab Med, HajdukVeljkova 3, Novi Sad 21000, Serbia.
EM branislava.ilincic@mf.uns.ac.rs
RI Mikhailidis, Dimitri/A-1869-2013; Isenovic, Esma/D-3017-2009; KATSIKI,
   NIKI/ADE-7999-2022
OI Isenovic, Esma/0000-0002-0012-2636; KATSIKI, NIKI/0000-0003-0894-2644
FU Ministry of Science, Education and Technological development, Republic
   of Serbia [173033]
FX This study was supported by a grant funded by the Ministry of Science,
   Education and Technological development, Republic of Serbia, No. 173033
   (to ERI).
CR Al Mheid I, 2011, J AM COLL CARDIOL, V58, P186, DOI 10.1016/j.jacc.2011.02.051
   Bellien J, 2008, FUND CLIN PHARMACOL, V22, P363, DOI 10.1111/j.1472-8206.2008.00610.x
   Bosanská L, 2010, PHYSIOL RES, V59, P79, DOI 10.33549/physiolres.931705
   Chen N, 2014, NUTRIENTS, V6, P2206, DOI 10.3390/nu6062206
   Cheng S, 2010, DIABETES, V59, P242, DOI 10.2337/db09-1011
   de Jongh RT, 2004, CIRCULATION, V109, P2529, DOI 10.1161/01.CIR.0000129772.26647.6F
   Deanfield JE, 2007, CIRCULATION, V115, P1285, DOI 10.1161/CIRCULATIONAHA.106.652859
   Devaraj S, 2011, CLIN CHEM, V57, P1757, DOI 10.1373/clinchem.2011.169839
   Drincic AT, 2012, OBESITY, V20, P1444, DOI 10.1038/oby.2011.404
   Ertek S, 2012, ARCH MED SCI, V8, P47, DOI 10.5114/aoms.2012.27280
   Goch A, 2009, CLIN EXP HYPERTENS, V31, P20, DOI 10.1080/10641960802409846
   Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
   Grundy SM, 2004, CIRCULATION, V110, P227, DOI 10.1161/01.CIR.0000133317.49796.0E
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Jablonski KL, 2011, HYPERTENSION, V57, P63, DOI 10.1161/HYPERTENSIONAHA.110.160929
   Jonk AM, 2011, MICROVASC RES, V82, P423, DOI 10.1016/j.mvr.2011.08.006
   Katsiki N, 2014, CURR VASC PHARMACOL, V12, P627, DOI 10.2174/15701611113119990131
   Keogh JB, 2008, AM J CLIN NUTR, V87, P567, DOI 10.1093/ajcn/87.3.567
   Liu EJ, 2010, AM J CLIN NUTR, V91, P1627, DOI 10.3945/ajcn.2009.28441
   Ma AJ, 2014, ARCH MED SCI, V10, P47, DOI 10.5114/aoms.2013.39200
   Martinesi M, 2008, INFLAMM BOWEL DIS, V14, P597, DOI 10.1002/ibd.20354
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Michalska-Kasiczak M, 2015, INT J CARDIOL, V178, P111, DOI 10.1016/j.ijcard.2014.10.118
   Molinari C, 2011, CELL PHYSIOL BIOCHEM, V27, P661, DOI 10.1159/000330075
   Mulvihill NT, 2002, EUR HEART J, V23, P1569, DOI 10.1053/euhj.2002.3188
   Naumovic Nada, 2010, Med Pregl, V63, P301
   Ngo DT, 2010, AM J MED, V123, P335, DOI 10.1016/j.amjmed.2009.09.024
   Oz F, 2013, CORONARY ARTERY DIS, V24, P392, DOI 10.1097/MCA.0b013e328362b2c8
   Parikh NI, 2009, OBESITY, V17, P2054, DOI 10.1038/oby.2009.60
   Pereira-Santos M, 2015, OBES REV, V16, P341, DOI 10.1111/obr.12239
   Polidoro L, 2013, J CARDIOVASC TRANSL, V6, P221, DOI 10.1007/s12265-012-9436-x
   Pontiroli AF, 2004, EUR J ENDOCRINOL, V150, P195, DOI 10.1530/eje.0.1500195
   Pou KM, 2007, CIRCULATION, V116, P1234, DOI 10.1161/CIRCULATIONAHA.107.710509
   Rodríguez-Hernández H, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/678159
   Scalia R, 2013, REV ENDOCR METAB DIS, V14, P69, DOI 10.1007/s11154-013-9236-x
   Spiro A, 2014, NUTR BULL, V39, P322, DOI 10.1111/nbu.12108
   Stokic E, 2015, ANGIOLOGY, V66, P237, DOI 10.1177/0003319714528569
   Sun SY, 2012, ANNU REV NUTR, V32, P261, DOI 10.1146/annurev-nutr-071811-150623
   Tarcin O, 2009, J CLIN ENDOCR METAB, V94, P4023, DOI 10.1210/jc.2008-1212
   Tchernof A, 2013, PHYSIOL REV, V93, P359, DOI 10.1152/physrev.00033.2011
   Uberti F, 2014, J CLIN ENDOCR METAB, V99, P1367, DOI 10.1210/jc.2013-2103
   Vanlint S, 2013, NUTRIENTS, V5, P949, DOI 10.3390/nu5030949
   Wamberg L, 2013, EUR J INTERN MED, V24, P644, DOI 10.1016/j.ejim.2013.03.005
   Wilson PWF, 2008, CIRC-CARDIOVASC QUAL, V1, P92, DOI 10.1161/CIRCOUTCOMES.108.831198
NR 44
TC 27
Z9 28
U1 0
U2 5
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1734-1922
EI 1896-9151
J9 ARCH MED SCI
JI Arch. Med. Sci.
PD FEB
PY 2017
VL 13
IS 1
BP 53
EP 60
DI 10.5114/aoms.2016.61812
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EG3YS
UT WOS:000390981200003
PM 28144255
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Bayliak, MM
   Dmytriv, TR
   Melnychuk, AV
   Strilets, NV
   Storey, KB
   Lushchak, VI
AF Bayliak, Maria M.
   Dmytriv, Tetiana R.
   Melnychuk, Antonina, V
   Strilets, Nadia, V
   Storey, Kenneth B.
   Lushchak, Volodymyr, I
TI CHAMOMILE AS A POTENTIAL REMEDY FOR OBESITY AND METABOLIC SYNDROME
SO EXCLI JOURNAL
LA English
DT Review
DE Chamomile; polyphenols; inflammation; pro-oxidant; Nrf2; PPAR
ID ACTIVATED PROTEIN-KINASE; RECUTITA L. RAUSCHERT; MATRICARIA-CHAMOMILLA;
   ADIPOSE-TISSUE; OXIDATIVE STRESS; PPAR-GAMMA; INSULIN-RESISTANCE;
   ESSENTIAL OIL; ANTIMICROBIAL ACTIVITY; INFLAMMATORY RESPONSE
AB Obesity is an increasing health concern related to many metabolic disorders, including metabolic syndrome, diabetes type 2 and cardiovascular diseases. Many studies suggest that herbal products can be useful dietary supplements for weight management due to the presence of numerous biologically active compounds, including antioxidant polyphenols that can counteract obesity-related oxidative stress. In this review we focus on Matricaria chamomilla, commonly known as chamomile, and one of the most popular medicinal plants in the world. Thanks to a high content of phenolic compounds and essential oils, preparations from chamomile flowers demonstrate a number of pharmacological effects, including antioxidant, anti-inflammatory, antimicrobial and sedative actions as well as improving gastrointestinal function. Several recent studies have shown certain positive effects of chamomile preparations in the prevention of obesity and complications of diabetes. These effects were associated with modulation of signaling pathways involving the AMP-activated protein kinase, NF-kappa B, Nrf2 and PPAR. transcription factors. However, the potential of chamomile in the management of obesity seems to be underestimated. This review summarizes current data on the use of chamomile and its individual components (apigenin, luteolin, essential oils) to treat obesity and related metabolic disorders in cell and animal models and in human studies. Special attention is paid to molecular mechanisms that can be involved in the anti-obesity effects of chamomile preparations. Limitation of chamomile usage is also analyzed.
C1 [Bayliak, Maria M.; Dmytriv, Tetiana R.; Melnychuk, Antonina, V; Strilets, Nadia, V; Lushchak, Volodymyr, I] Vasyl Stefanyk Precarpathian Natl Univ, Dept Biochem & Biotechnol, 57 Shevchenko Str, UA-76018 Ivano Frankivsk, Ukraine.
   [Lushchak, Volodymyr, I] I Horbachevsky Ternopil Natl Med Univ, UA-46002 Ternopol, Ukraine.
   [Lushchak, Volodymyr, I] Res & Dev Univ, Shota Rustaveli Str, UA-76018 Ivano Frankivsk, Ukraine.
   [Storey, Kenneth B.] Carleton Univ, Inst Biochem, 1125 Colonel By Dr, Ottawa, ON K1S 5B6, Canada.
C3 Ministry of Education & Science of Ukraine; Vasyl Stefanyk Precarpathian
   National University; I. Horbachevsky Ternopil State Medical University;
   Carleton University
RP Bayliak, MM (corresponding author), Vasyl Stefanyk Precarpathian Natl Univ, Dept Biochem & Biotechnol, 57 Shevchenko Str, UA-76018 Ivano Frankivsk, Ukraine.
EM maria.bayliak@pnu.edu.ua
RI Storey, Kenneth/G-9883-2011; Lushchak, Volodymyr/AAV-4256-2021; Dmytriv,
   Tetiana/HLX-5759-2023; Bayliak, Maria/P-8950-2015
OI Bayliak, Maria/0000-0001-6268-8910; Dmytriv, Tetiana/0000-0001-9467-1267
FU Ministry of Education and Science of Ukraine [0118U003477]; National
   Research Foundation of Ukraine [2020.02/0118]
FX This work was partially supported by a grant from the Ministry of
   Education and Science of Ukraine (#0118U003477) to VIL and a grant from
   National Research Foundation of Ukraine (#2020.02/0118) to MMB.
CR Aggoun Y, 2007, PEDIATR RES, V61, P653, DOI [10.1203/pdr.0b013e31805d8a8c, 10.1210/jc.2004-0372]
   Ahmad A, 1997, INT J PHARMACOGN, V35, P121, DOI 10.1076/phbi.35.2.121.13280
   Al-Jubouri H. H. F., 1990, Journal of the Faculty of Medicine (Baghdad), V32, P5
   Albrecht U, 2014, BMJ OPEN GASTROENTER, V1, DOI 10.1136/bmjgast-2014-000015
   Amsterdam JD, 2009, J CLIN PSYCHOPHARM, V29, P378, DOI 10.1097/JCP.0b013e3181ac935c
   Anzai A, 2015, CONTACT DERMATITIS, V72, P254, DOI 10.1111/cod.12353
   Aranaz P, 2019, MOLECULES, V24, DOI 10.3390/molecules24061045
   Baek Y, 2019, J NUTR BIOCHEM, V71, P72, DOI 10.1016/j.jnutbio.2019.06.002
   Bayliak MM, 2020, PROG INFLAMM RES SER, V85, P153, DOI 10.1007/978-3-030-44599-7_7
   Bayliak MM, 2019, COMP BIOCHEM PHYS A, V228, P18, DOI 10.1016/j.cbpa.2018.09.027
   Bayliak MM, 2016, OPEN LIFE SCI, V11, P298, DOI 10.1515/biol-2016-0040
   Benito P, 2014, J INVEST ALLERG CLIN, V24, P369
   Bhaskaran N, 2010, INT J MOL MED, V26, P935, DOI 10.3892/ijmm_00000545
   Bray GA, 2017, OBES REV, V18, P715, DOI 10.1111/obr.12551
   Bumke-Vogt C, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0104321
   Capuzzo A, 2014, NAT PROD RES, V28, P2321, DOI 10.1080/14786419.2014.931393
   Catrysse L, 2017, TRENDS CELL BIOL, V27, P417, DOI 10.1016/j.tcb.2017.01.006
   Cavalcante HAO, 2020, INFLAMMATION, V43, P193, DOI 10.1007/s10753-019-01109-8
   Cemek M, 2008, J NAT MED-TOKYO, V62, P284, DOI 10.1007/s11418-008-0228-1
   Coelho M, 2013, ARCH MED SCI, V9, P191, DOI 10.5114/aoms.2013.33181
   Deren K, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-21773-4
   Dewanjee S, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21062217
   Fernandes MYD, 2019, EUR J PHARMACOL, V842, P270, DOI 10.1016/j.ejphar.2018.09.036
   Ding L, 2010, J NUTR BIOCHEM, V21, P941, DOI 10.1016/j.jnutbio.2009.07.009
   de Franco EPD, 2020, J ENZYM INHIB MED CH, V35, P42, DOI 10.1080/14756366.2019.1681989
   Drummond EM, 2013, PHYTOTHER RES, V27, P588, DOI 10.1002/ptr.4753
   Dubois V, 2017, J CLIN INVEST, V127, P1202, DOI 10.1172/JCI88894
   European Medicines Agency, 2015, EMAHMPC558372011
   Fang X, 2006, BIOCHEM SOC T, V34, P798, DOI 10.1042/BST0340798
   Feng SM, 2020, COMPR REV FOOD SCI F, V19, P1243, DOI 10.1111/1541-4337.12560
   Feng XJ, 2017, BIOCHEM PHARMACOL, V136, P136, DOI 10.1016/j.bcp.2017.04.014
   Feng XJ, 2016, EBIOMEDICINE, V9, P61, DOI 10.1016/j.ebiom.2016.06.017
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Foti MC, 2007, J PHARM PHARMACOL, V59, P1673, DOI 10.1211/jpp.59.12.0010
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Garaschuk O, 2018, AGEING RES REV, V43, P26, DOI 10.1016/j.arr.2018.02.003
   Gastaldelli A, 2017, DIABETES, V66, P815, DOI 10.2337/db16-1167
   Gentile D, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01094
   Gentile D, 2018, NUTR RES REV, V31, P239, DOI 10.1017/S0954422418000082
   Gentile D, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0195502
   Ghasemi M, 2016, FOODS, V5, DOI 10.3390/foods5030056
   Goldberg IJ, 1996, J LIPID RES, V37, P693
   Gómez-Zorita S, 2017, J TRANSL MED, V15, DOI 10.1186/s12967-017-1343-0
   González-Castejón M, 2011, PHARMACOL RES, V64, P438, DOI 10.1016/j.phrs.2011.07.004
   Guo H, 2020, PPAR RES, V2020, DOI 10.1155/2020/8889612
   Hadrich F, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0738-0
   Haghi G, 2014, RES PHARM SCI, V9, P31
   Hajizadeh-Sharafabad F, 2020, COMPLEMENT THER MED, V48, DOI 10.1016/j.ctim.2019.102284
   Hernandez-Quiles M, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.624112
   Hu WC, 2016, FOOD FUNCT, V7, P1002, DOI 10.1039/c5fo01212k
   Jabri MA, 2022, NUTR NEUROSCI, V25, P1350, DOI 10.1080/1028415X.2020.1859727
   Jabri MA, 2016, LIPIDS HEALTH DIS, V15, DOI 10.1186/s12944-016-0233-4
   Jung UJ, 2016, NUTRIENTS, V8, DOI 10.3390/nu8050305
   Kanda Y, 2011, LIFE SCI, V89, P250, DOI 10.1016/j.lfs.2011.06.007
   Kato A, 2008, J AGR FOOD CHEM, V56, P8206, DOI 10.1021/jf8014365
   Kazemi M, 2015, INT J FOOD PROP, V18, P1784, DOI 10.1080/10942912.2014.939660
   Khan SS, 2014, PAK J PHARM SCI, V27, P1509
   Kim S, 2011, FOOD CHEM TOXICOL, V49, P2580, DOI 10.1016/j.fct.2011.06.076
   Klotz LO, 2015, REDOX BIOL, V6, P51, DOI 10.1016/j.redox.2015.06.019
   Kolodziejczyk-Czepas J, 2015, INT J BIOL MACROMOL, V72, P1152, DOI 10.1016/j.ijbiomac.2014.09.032
   KOTOV AG, 1991, KHIM PRIR SOEDIN+, P853
   Kwon EY, 2018, NUTRIENTS, V10, DOI 10.3390/nu10101415
   Kwon EY, 2015, DIABETES, V64, P1658, DOI 10.2337/db14-0631
   Langin D, 2006, PHARMACOL RES, V53, P482, DOI 10.1016/j.phrs.2006.03.009
   Lee C, 2017, OXID MED CELL LONGEV, V2017, P1, DOI 10.1155/2017/1378175
   Lihn AS, 2005, OBES REV, V6, P13, DOI 10.1111/j.1467-789X.2005.00159.x
   Lim HJ, 2006, PROSTAG OTH LIPID M, V80, P165, DOI 10.1016/j.prostaglandins.2006.06.006
   Liu Y, 2014, BEHAV BRAIN RES, V267, P178, DOI 10.1016/j.bbr.2014.02.040
   López-Lázaro M, 2009, MINI-REV MED CHEM, V9, P31, DOI 10.2174/138955709787001712
   Lu J, 2019, EXP THER MED, V18, P2965, DOI 10.3892/etm.2019.7905
   Lundh K, 2007, CONTACT DERMATITIS, V57, P218, DOI 10.1111/j.1600-0536.2007.01226.x
   Lushchak VI, 2021, PFLUG ARCH EUR J PHY, V473, P713, DOI 10.1007/s00424-021-02531-4
   Lushchak VI, 2011, COMP BIOCHEM PHYS C, V153, P175, DOI 10.1016/j.cbpc.2010.10.004
   Lv YA, 2019, J NUTR BIOCHEM, V71, P110, DOI 10.1016/j.jnutbio.2019.05.015
   Ma D, 2020, BIOSCI BIOTECH BIOCH, V84, P402, DOI 10.1080/09168451.2019.1682511
   Ma XR, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00473
   Manach C, 2005, AM J CLIN NUTR, V81, p230S, DOI 10.1093/ajcn/81.1.230S
   Mao JJ, 2016, PHYTOMEDICINE, V23, P1735, DOI 10.1016/j.phymed.2016.10.012
   Maréchal L, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19051529
   Marusic M, 2021, CAN J GASTROENTEROL, V2021, DOI 10.1155/2021/6613827
   Masania J, 2016, GLYCOCONJUGATE J, V33, P581, DOI 10.1007/s10719-016-9692-0
   Matsuda M, 2013, OBES RES CLIN PRACT, V7, pE330, DOI 10.1016/j.orcp.2013.05.004
   McKay DL, 2006, PHYTOTHER RES, V20, P519, DOI 10.1002/ptr.1900
   Mehta M, 2021, ENDOCR PRACT, V27, P626, DOI 10.1016/j.eprac.2021.04.001
   Miguel FG, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/828437
   Molnar M, 2017, CHEM CENT J, V11, DOI 10.1186/s13065-017-0308-y
   Morigny P, 2016, BIOCHIMIE, V125, P259, DOI 10.1016/j.biochi.2015.10.024
   Morín FDT, 2001, J INVEST ALLERG CLIN, V11, P118
   Rocha NFM, 2011, N-S ARCH PHARMACOL, V384, P525, DOI 10.1007/s00210-011-0679-x
   Mulinacci N, 2000, CHROMATOGRAPHIA, V51, P301, DOI 10.1007/BF02490607
   Nagy L, 1998, CELL, V93, P229, DOI 10.1016/S0092-8674(00)81574-3
   Najla O.A., 2012, J HEALTH SCI, V2, P43, DOI 10.5923/j.health.20120205.01
   Nakae J, 2008, DIABETES, V57, P563, DOI 10.2337/db07-0698
   Nakagawa M, 2019, ALLERGOL INT, V68, P396, DOI 10.1016/j.alit.2019.02.011
   Ordovas JM, 2008, KIDNEY INT, V74, pS10, DOI 10.1038/ki.2008.517
   Pallauf K, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/4397340
   Panda S, 2007, J PHARM PHARMACOL, V59, P1543, DOI 10.1211/jpp.59.11.0012
   Park HS, 2020, J FOOD BIOCHEM, V44, DOI 10.1111/jfbc.13358
   Paulsen E, 2008, CONTACT DERMATITIS, V58, P15
   Paulsen E, 2010, CONTACT DERMATITIS, V62, P338, DOI 10.1111/j.1600-0536.2010.01730.x
   Chaves PFP, 2020, INT J BIOL MACROMOL, V164, P1675, DOI 10.1016/j.ijbiomac.2020.08.039
   Pérez-Torres I, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22041786
   Priceman SJ, 2013, P NATL ACAD SCI USA, V110, P13079, DOI 10.1073/pnas.1311557110
   Querio G, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00246
   Raal A, 2012, FOOD CHEM, V131, P632, DOI 10.1016/j.foodchem.2011.09.042
   Rafraf M, 2015, J ENDOCRINOL INVEST, V38, P163, DOI 10.1007/s40618-014-0170-x
   Rauter AP, 2010, PHYTOTHER RES, V24, pS133, DOI 10.1002/ptr.3017
   REDAELLI C, 1981, J CHROMATOGR, V209, P110, DOI 10.1016/S0021-9673(00)80433-1
   Reider N, 2000, CLIN EXP ALLERGY, V30, P1436, DOI 10.1046/j.1365-2222.2000.00902.x
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Salehi B, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20061305
   Salminen A, 2012, AGEING RES REV, V11, P230, DOI 10.1016/j.arr.2011.12.005
   Scala G, 2006, INT ARCH ALLERGY IMM, V139, P330, DOI 10.1159/000091605
   Segal R, 2006, CAN MED ASSOC J, V174, P1281, DOI 10.1503/cmaj.051191
   Semchyshyn H, 2021, PFLUG ARCH EUR J PHY, V473, P723, DOI 10.1007/s00424-021-02529-y
   Semchyshyn HM, 2014, SCI WORLD J, DOI 10.1155/2014/417842
   Sharifi-Rad M, 2018, MICROBIOL RES, V215, P76, DOI 10.1016/j.micres.2018.06.010
   SHULMAN GI, 2000, J CLIN INVEST, V106, P171, DOI [DOI 10.1172/JCI10583, 10.1172/jci10583]
   Singh Ompal, 2011, Pharmacogn Rev, V5, P82, DOI 10.4103/0973-7847.79103
   Slocum SL, 2016, ARCH BIOCHEM BIOPHYS, V591, P57, DOI 10.1016/j.abb.2015.11.040
   Smith U, 2016, J INTERN MED, V280, P465, DOI 10.1111/joim.12540
   Srivastava JK, 2010, MOL MED REP, V3, P895, DOI 10.3892/mmr.2010.377
   Stanojevic LP, 2016, J ESSENT OIL BEAR PL, V19, P2017, DOI 10.1080/0972060X.2016.1224689
   Su SS, 2015, GENE, V571, P58, DOI 10.1016/j.gene.2015.06.037
   Su T, 2020, PHARMACOL RES, V152, DOI 10.1016/j.phrs.2019.104586
   SUBIZA J, 1990, ANN ALLERGY, V65, P127
   Suh KS, 2012, BIOL PHARM BULL, V35, P121, DOI 10.1248/bpb.35.121
   Tanaka T, 2014, CSH PERSPECT BIOL, V6, DOI 10.1101/cshperspect.a016295
   Tinahones FJ, 2009, OBESITY, V17, P240, DOI 10.1038/oby.2008.536
   Trayhurn P, 2004, BRIT J NUTR, V92, P347, DOI 10.1079/BJN20041213
   Vaiserman A, 2018, AGEING RES REV, V47, P105, DOI 10.1016/j.arr.2018.07.007
   van Eenige R, 2018, TRENDS ENDOCRIN MET, V29, P326, DOI 10.1016/j.tem.2018.03.001
   Viapiana A, 2016, FRONT PLANT SCI, V7, DOI 10.3389/fpls.2016.01561
   Villa-Rodriguez JA, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-23736-1
   Wang MQ, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/7010467
   Wang W, 2020, J PHARM PHARMACOL, V72, P1645, DOI 10.1111/jphp.13347
   Wang X, 2020, OPEN LIFE SCI, V15, P251, DOI 10.1515/biol-2020-0026
   Weidner C, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0080335
   Wu LL, 2021, J PHARMACOL EXP THER, V377, P146, DOI 10.1124/jpet.120.000162
   Xiao ZJ, 2014, PLOS ONE, V9, DOI [10.1371/journal.pone.0101251, 10.1371/journal.pone.0107072]
   Yanai H, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20051190
   Yang M, 2018, BIOMED PHARMACOTHER, V105, P1283, DOI 10.1016/j.biopha.2018.06.108
   Yu HY, 2021, CELL SIGNAL, V84, DOI 10.1016/j.cellsig.2021.110043
   Zang MW, 2006, DIABETES, V55, P2180, DOI 10.2337/db05-1188
   Zemestani M, 2016, NUTRITION, V32, P66, DOI 10.1016/j.nut.2015.07.011
   Zhang L, 2016, DIABETOLOGIA, V59, P2219, DOI 10.1007/s00125-016-4039-8
   Zhang X, 2016, INT J OBESITY, V40, P1841, DOI 10.1038/ijo.2016.108
   Zhang YJ, 2015, MOLECULES, V20, P21138, DOI 10.3390/molecules201219753
   Zhong QQ, 2015, INT J BIOL SCI, V11, P256, DOI 10.7150/ijbs.10258
   Zhu DQ, 2011, BIOCHIMIE, V93, P506, DOI 10.1016/j.biochi.2010.11.002
NR 150
TC 25
Z9 27
U1 1
U2 30
PU EXCLI JOURNAL MANAGING OFFICE
PI DORTMUND
PA LEIBNIZ RESEARCH CENTRE WORKING ENVIRONMENT & HUMAN FACTORS EXCLI
   JOURNAL, ARDEYSTR 67, DORTMUND, D-44139, GERMANY
SN 1611-2156
J9 EXCLI J
JI EXCLI J.
PY 2021
VL 20
DI 10.17179/excli2021-4013
PG 26
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA TX5CM
UT WOS:000683105200001
PM 34602925
DA 2025-06-11
ER

PT J
AU Thomas-Valdés, S
   Theoduloz, C
   Jiménez-Aspee, F
   Burgos-Edwards, A
   Schmeda-Hirschmann, G
AF Thomas-Valdes, Samanta
   Theoduloz, Cristina
   Jimenez-Aspee, Felipe
   Burgos-Edwards, Alberto
   Schmeda-Hirschmann, Guillermo
TI Changes in polyphenol composition and bioactivity of the native Chilean
   white strawberry (Fragaria chiloensis spp. chiloensis f.
   chiloensis) after in vitro gastrointestinal digestion
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Article
DE Fragaria chiloensis; In vitro digestion; Polyphenolic profiles;
   Antioxidant activity; Metabolic syndrome-associated enzymes;
   HPLC-DAD-MS/MSn
ID ALPHA-GLUCOSIDASE; ANTIOXIDANT ACTIVITY; OXIDATIVE STRESS;
   RIBES-MAGELLANICUM; METABOLIC SYNDROME; AMYLASE; LIPASE; FRUITS;
   PROANTHOCYANIDINS; STABILITY
AB The Chilean white strawberry (Fragaria chiloensis spp. chiloensis f. chiloensis) is a semi-domesticated strawberry with high polyphenol content and antioxidant activity occurring in southern Chile. The aim of this work was to compare the composition and bioactivity of the polyphenol-enriched fruit extract (PEE) before and after simulated gastrointestinal digestion (GID). Results show a decrease by > 50% in the total phenolic (TP) content at the end of the GID, compared to the non-digested PEE. A reduction in the antioxidant capacity of the PEEs was observed after GID by means of DPPH, FRAP, TEAC and anion superoxide assays. After simulated GID the PEE significantly inhibited alpha-glucosidase with an IC50 value of 3.13 mu g/mL. The inhibition of pancreatic lipase was reduced by 95% after GID. All the PEEs did not show inhibitory effect towards alpha-amylase throughout the GID. In the same way, the PEEs did not significantly protect human gastric adenocarcinoma (AGS) cells against H2O2 induced stress. Thirty eight compounds were tentatively identified in the non-digested PEE. The compounds that were more affected by the simulated GID were simple phenolics. After the GID, only 33 and 25 compounds were detected, in the gastric and intestinal steps, respectively. These results evidence the changes elicited by GID on the bioactivity and polyphenolic composition of the white strawberry.
C1 [Thomas-Valdes, Samanta; Burgos-Edwards, Alberto; Schmeda-Hirschmann, Guillermo] Univ Talca, Inst Quim Recursos Nat, Lab Quim Prod Nat, Talca, Chile.
   [Theoduloz, Cristina] Univ Talca, Fac Ciencias Salud, Lab Cult Celular, Talca, Chile.
   [Jimenez-Aspee, Felipe] Univ Talca, Fac Ciencias Salud, Dept Ciencias Basicas Biomed, Talca, Chile.
   [Thomas-Valdes, Samanta] Univ Valparaiso, Fac Farm, Escuela Nutr & Dietet, Valparaiso, Chile.
C3 Universidad de Talca; Universidad de Talca; Universidad de Talca;
   Universidad de Valparaiso
RP Schmeda-Hirschmann, G (corresponding author), Univ Talca, Inst Quim Recursos Nat, Lab Quim Prod Nat, Talca, Chile.
EM schmeda@utalca.cl
RI Thomas-Valdés, Samanta/H-4807-2018; Aspee, Felipe/ABA-2948-2020; Jimenez
   Aspee, Felipe/G-6955-2017; Schmeda Hirschmann, Guillermo/G-1046-2010
OI Burgos-Edwards, Alberto/0000-0001-8286-8556; Thomas-Valdes,
   Samanta/0000-0002-1813-2728; Jimenez Aspee, Felipe/0000-0002-7285-7033;
   Schmeda Hirschmann, Guillermo/0000-0002-9228-5378
FU CONICYT-PCHA/Doctorado Nacional [2013-63130042, 2015-21151561]; Nucleo
   Cientifico Multidisciplinario; PIEI-QUIM-BIO, Universidad de Talca
FX Financial support from CONICYT-PCHA/Doctorado Nacional/2013-63130042 (S.
   Thomas-Valdes), CONICYT-PCHA/Doctorado Nacional/2015-21151561 (A. Burgos
   Edwards), Nucleo Cientifico Multidisciplinario and PIEI-QUIM-BIO,
   Universidad de Talca, are kindly acknowledged.
CR Bergmann H, 2009, MOL NUTR FOOD RES, V53, P1211, DOI 10.1002/mnfr.200800498
   Bhandari MR, 2008, FOOD CHEM, V106, P247, DOI 10.1016/j.foodchem.2007.05.077
   Birari RB, 2007, DRUG DISCOV TODAY, V12, P879, DOI 10.1016/j.drudis.2007.07.024
   Boath A. S., 2012, Food Digestion, V3, P1
   Bohn T., 2017, CRITICAL REV FOOD SC
   Bouayed J, 2011, FOOD CHEM, V128, P14, DOI 10.1016/j.foodchem.2011.02.052
   Burgos-Edwards A, 2017, FOOD CHEM, V237, P1073, DOI 10.1016/j.foodchem.2017.06.060
   Cheel J, 2007, FOOD CHEM, V102, P36, DOI 10.1016/j.foodchem.2006.04.036
   Cheli F, 2011, J FOOD SCI, V76, pR197, DOI 10.1111/j.1750-3841.2011.02411.x
   Correa-Betanzo J, 2014, FOOD CHEM, V165, P522, DOI 10.1016/j.foodchem.2014.05.135
   Costamagna MS, 2016, FOOD CHEM, V190, P392, DOI 10.1016/j.foodchem.2015.05.068
   Ercan P, 2016, FOOD CHEM, V205, P163, DOI 10.1016/j.foodchem.2016.03.012
   Orqueda ME, 2017, FOOD CHEM, V216, P70, DOI 10.1016/j.foodchem.2016.08.015
   Fracassetti D, 2013, FOOD CHEM, V139, P578, DOI 10.1016/j.foodchem.2013.01.121
   Friscic M, 2016, J MASS SPECTROM, V51, P1211, DOI 10.1002/jms.3844
   Ghani U, 2015, EUR J MED CHEM, V103, P133, DOI 10.1016/j.ejmech.2015.08.043
   Giampieri F, 2014, FOOD FUNCT, V5, P1939, DOI [10.1039/c4fo00048j, 10.1039/C4FO00048J]
   Gullon B, 2015, FOOD RES INT, V78, P169, DOI 10.1016/j.foodres.2015.10.021
   Gullon B, 2015, J FUNCT FOODS, V19, P617, DOI 10.1016/j.jff.2015.09.056
   Guo X, 2016, EUR J CLIN NUTR, V70, P1360, DOI 10.1038/ejcn.2016.142
   Heim KE, 2002, J NUTR BIOCHEM, V13, P572, DOI 10.1016/S0955-2863(02)00208-5
   Heo HJ, 2008, J FOOD SCI, V73, pH28, DOI 10.1111/j.1750-3841.2007.00632.x
   Huang HZ, 2014, FOOD CHEM, V146, P363, DOI 10.1016/j.foodchem.2013.09.071
   Jiménez-Aspee F, 2016, FOOD SCI NUTR, V4, P595, DOI 10.1002/fsn3.323
   Jiménez-Aspee F, 2016, FOOD CHEM, V194, P908, DOI 10.1016/j.foodchem.2015.08.117
   Li Q, 2015, FOOD RES INT, V78, P378, DOI 10.1016/j.foodres.2015.09.004
   Li Y, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17081258
   Lin LZ, 2014, J AGR FOOD CHEM, V62, P9387, DOI 10.1021/jf501011y
   López-Alarcón C, 2013, ANAL CHIM ACTA, V763, P1, DOI 10.1016/j.aca.2012.11.051
   Lucas-Gonzalez R, 2016, IND CROP PROD, V94, P774, DOI 10.1016/j.indcrop.2016.09.057
   McDougall GJ, 2005, J AGR FOOD CHEM, V53, P2760, DOI 10.1021/jf0489926
   McDougall GJ, 2009, FOOD CHEM, V115, P193, DOI 10.1016/j.foodchem.2008.11.093
   Minekus M, 2014, FOOD FUNCT, V5, P1113, DOI 10.1039/c3fo60702j
   Pavan V, 2014, LWT-FOOD SCI TECHNOL, V59, P1247, DOI 10.1016/j.lwt.2014.05.040
   Retamales JB, 2005, HORTSCIENCE, V40, P1633, DOI 10.21273/HORTSCI.40.6.1633
   Rubilar M, 2011, J AGR FOOD CHEM, V59, P1630, DOI 10.1021/jf103461k
   Simirgiotis MJ, 2010, J FOOD COMPOS ANAL, V23, P545, DOI 10.1016/j.jfca.2009.08.020
   Svensson L, 2010, J AGR FOOD CHEM, V58, P9214, DOI 10.1021/jf101504v
   Tan YQ, 2017, FOOD CHEM, V214, P259, DOI 10.1016/j.foodchem.2016.06.100
   Tavares L, 2012, FOOD CHEM, V131, P1443, DOI 10.1016/j.foodchem.2011.10.025
   Tomé-Carneiro J, 2016, PHYTOMEDICINE, V23, P1145, DOI 10.1016/j.phymed.2015.10.018
   Törrönen R, 2012, AM J CLIN NUTR, V96, P527, DOI 10.3945/ajcn.112.042184
   Zhang H, 2016, CURR OPIN FOOD SCI, V8, P33, DOI 10.1016/j.cofs.2016.02.002
NR 43
TC 40
Z9 42
U1 0
U2 72
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0963-9969
EI 1873-7145
J9 FOOD RES INT
JI Food Res. Int.
PD MAR
PY 2018
VL 105
BP 10
EP 18
DI 10.1016/j.foodres.2017.10.074
PG 9
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA FW8GJ
UT WOS:000425567900002
PM 29433189
DA 2025-06-11
ER

PT J
AU Di Bartolomeo, F
   Van den Ende, W
AF Di Bartolomeo, Francesca
   Van den Ende, Wim
TI Fructose and Fructans: Opposite Effects on Health?
SO PLANT FOODS FOR HUMAN NUTRITION
LA English
DT Review
DE Diabetes; Health; Food; Fructan; Fructose; Prebiotics; Oxidative stress
ID RETINOL-BINDING PROTEIN-4; INSULIN SENSITIVITY; URIC-ACID; BODY-WEIGHT;
   SWEETENED BEVERAGES; INTESTINAL BARRIER; METABOLIC SYNDROME;
   FATTY-ACIDS; STRESS; LIVER
AB Fructans are fructose-based oligo-and polysaccharides of natural origin. Fructan and fructose species are sometimes confused by the great public, although they clearly have different biochemical and physiological properties. This review discusses aspects of the use of fructose and fructans in foods in the context of human health, with possible differential effects on cellular autophagy in cells of the human body. Although there are uncertainties on the daily levels of ingested fructose to be considered harmful to human health, there is an emerging consensus on the benefits of the use of fructans in functional foods, sustaining health via direct immunomodulatory and antioxidant effects or through indirect, prebiotic mechanisms.
C1 [Di Bartolomeo, Francesca] Graz Univ Technol, Inst Biochem, A-8010 Graz, Austria.
   [Van den Ende, Wim] Katholieke Univ Leuven, Plant Mol Biol Lab, B-3001 Leuven, Belgium.
   [Van den Ende, Wim] Katholieke Univ Leuven, L FoRCe, B-3001 Leuven, Belgium.
C3 Graz University of Technology; KU Leuven; KU Leuven
RP Van den Ende, W (corresponding author), Katholieke Univ Leuven, Plant Mol Biol Lab, Kasteelpk Arenberg 31, B-3001 Leuven, Belgium.
EM wim.vandenende@bio.kuleuven.be
RI ; Van den Ende, Wim/I-6899-2013
OI Di Bartolomeo, Francesca/0000-0002-4302-0701; Van den Ende,
   Wim/0000-0003-1137-3614
FU FWO Vlaanderen
FX Wim Van den Ende is supported by funding from FWO Vlaanderen. The
   authors thank Lukasz Pawel Tarkowski for his assistance in drawing
   figures.
CR Aeberli I, 2013, DIABETES CARE, V36, P150, DOI 10.2337/dc12-0540
   Allsopp P, 2013, ANAEROBE, V22, P38, DOI 10.1016/j.anaerobe.2013.05.006
   Anderson GH, 2003, NUTR REV, V61, pS17, DOI 10.1301/nr.2003.may.S17-S26
   Arroyo DS, 2014, INT IMMUNOPHARMACOL, V18, P55, DOI 10.1016/j.intimp.2013.11.001
   BARON AD, 1995, J CLIN INVEST, V96, P786, DOI 10.1172/JCI118124
   BARON H, 1968, J NUTR, V94, P95, DOI 10.1093/jn/94.1.95
   Barone S, 2009, J BIOL CHEM, V284, P5056, DOI 10.1074/jbc.M808128200
   Bremer AA, 2011, CTS-CLIN TRANSL SCI, V4, P243, DOI 10.1111/j.1752-8062.2011.00298.x
   Bruynseels K, 1999, NMR BIOMED, V12, P145, DOI 10.1002/(SICI)1099-1492(199905)12:3<145::AID-NBM559>3.0.CO;2-1
   Chong MFF, 2007, AM J CLIN NUTR, V85, P1511, DOI 10.1093/ajcn/85.6.1511
   Delgado GTC, 2013, PLANT FOOD HUM NUTR, V68, P222, DOI 10.1007/s11130-013-0362-0
   Corcoran MP, 2007, AM J CLIN NUTR, V85, P662
   Cox CL, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-68
   Di Bartolomeo F, 2013, PHYTOTHER RES, V27, P1457, DOI 10.1002/ptr.4901
   Douard V, 2008, AM J PHYSIOL-ENDOC M, V295, pE227, DOI 10.1152/ajpendo.90245.2008
   Duffy VB, 2004, J AM DIET ASSOC, V104, P255, DOI 10.1016/j.jada.2003.12.001
   Dyer J, 2002, AM J PHYSIOL-GASTR L, V282, pG241, DOI 10.1152/ajpgi.00310.2001
   Eiwegger T, 2010, PEDIAT ALLERG IMM-UK, V21, P1179, DOI 10.1111/j.1399-3038.2010.01062.x
   Elliott SS, 2002, AM J CLIN NUTR, V76, P911, DOI 10.1093/ajcn/76.5.911
   Faeh D, 2005, DIABETES, V54, P1907, DOI 10.2337/diabetes.54.7.1907
   FUCHS A, 1991, BIOCHEM SOC T, V19, P555, DOI 10.1042/bst0190555
   Giordano S, 2014, REDOX BIOL, V2, P82, DOI 10.1016/j.redox.2013.12.013
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Gwak MJ, 2012, FOOD SCI BIOTECHNOL, V21, P889, DOI 10.1007/s10068-012-0115-0
   Higuchi T, 2015, J CELL BIOCHEM, V116, P609, DOI 10.1002/jcb.25012
   Incoll L., 1993, Inulin and inulin- containing crops, P309
   Kang YL, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0113520
   Kelly G, 2008, ALTERN MED REV, V13, P315
   Keunen E, 2013, PLANT CELL ENVIRON, V36, P1242, DOI 10.1111/pce.12061
   Kim JK, 2004, J CLIN INVEST, V114, P823, DOI 10.1172/JCI200422230
   Kleessen B, 1997, AM J CLIN NUTR, V65, P1397, DOI 10.1093/ajcn/65.5.1397
   Klok MD, 2007, OBES REV, V8, P21, DOI 10.1111/j.1467-789X.2006.00270.x
   Kroemer G, 2010, MOL CELL, V40, P280, DOI 10.1016/j.molcel.2010.09.023
   Lammens W, 2009, J EXP BOT, V60, P727, DOI 10.1093/jxb/ern333
   Lanaspa MA, 2012, J BIOL CHEM, V287, P40732, DOI 10.1074/jbc.M112.399899
   Laughlin MR, 2014, NUTRIENTS, V6, P3117, DOI 10.3390/nu6083117
   LEVINE R, 1986, ANNU REV NUTR, V6, P211, DOI 10.1146/annurev.nu.06.070186.001235
   Lim JS, 2010, NAT REV GASTRO HEPAT, V7, P251, DOI 10.1038/nrgastro.2010.41
   Livesey G, 2008, AM J CLIN NUTR, V88, P1419, DOI 10.3945/ajcn.2007.25700
   Lopez G.M., 2007, In Recent Advances in Fructootigosaccharides Research, P297
   Matsuzaka T, 2004, DIABETES, V53, P560, DOI 10.2337/diabetes.53.3.560
   MAYES PA, 1993, AM J CLIN NUTR, V58, P754
   McGarry JD, 1997, EUR J BIOCHEM, V244, P1, DOI 10.1111/j.1432-1033.1997.00001.x
   Moore MC, 2001, DIABETES CARE, V24, P1882, DOI 10.2337/diacare.24.11.1882
   Mor I, 2011, COLD SH Q B, V76, P211, DOI 10.1101/sqb.2011.76.010868
   Nakagawa T, 2006, AM J PHYSIOL-RENAL, V290, pF625, DOI 10.1152/ajprenal.00140.2005
   NIEWOEHNER CB, 1986, J AM COLL NUTR, V5, P443
   Ortega-Gonzales M, 2014, PLOS ONE, V9, P1
   OSER BL, 1985, FOOD CHEM TOXICOL, V23, P535, DOI 10.1016/0278-6915(85)90148-6
   Pagliassotti MJ, 2002, AM J PHYSIOL-ENDOC M, V282, pE170, DOI 10.1152/ajpendo.2002.282.1.E170
   Pasqualetti V, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0098031
   Peng LY, 2009, J NUTR, V139, P1619, DOI 10.3945/jn.109.104638
   Peshev D, 2014, J FUNCT FOODS, V8, P348, DOI 10.1016/j.jff.2014.04.005
   Rendón-Huerta JA, 2012, PLANT FOOD HUM NUTR, V67, P64, DOI 10.1007/s11130-011-0266-9
   Rippe JM, 2013, ADV NUTR, V4, P236, DOI 10.3945/an.112.002824
   RUMESSEN JJ, 1990, AM J CLIN NUTR, V52, P675, DOI 10.1093/ajcn/52.4.675
   Samuel VT, 2010, LANCET, V375, P2267, DOI 10.1016/S0140-6736(10)60408-4
   Sauer J, 2007, J NUTR BIOCHEM, V18, P736, DOI 10.1016/j.jnutbio.2006.12.012
   Scholz-Ahrens KE, 2007, J NUTR, V137, p2513S, DOI 10.1093/jn/137.11.2513S
   Schwarz JM, 1993, DIABETES S, V42, P1
   Sluijs I, 2013, J NUTR, V143, P80, DOI 10.3945/jn.112.167221
   Stanhope KL, 2011, AM J CLIN NUTR, V94, P112, DOI 10.3945/ajcn.110.002246
   Stanhope KL, 2009, J CLIN INVEST, V119, P1322, DOI 10.1172/JCI37385
   Tamura K, 2009, J EXP BOT, V60, P893, DOI 10.1093/jxb/ern337
   Tarini J, 2010, APPL PHYSIOL NUTR ME, V35, P9, DOI 10.1139/H09-119
   Ten Bruggencate SJM, 2006, J NUTR, V136, P70, DOI 10.1093/jn/136.1.70
   Terra X, 2013, OBESITY, V21, P170, DOI 10.1002/oby.20233
   Ueno M, 2000, BRAZ J MED BIOL RES, V33, P1421, DOI 10.1590/S0100-879X2000001200004
   Valluru R, 2008, J EXP BOT, V59, P2905, DOI 10.1093/jxb/ern164
   Van den Ende W, 2011, TRENDS FOOD SCI TECH, V22, P689, DOI 10.1016/j.tifs.2011.07.005
   Van den Ende W, 2013, FRONT PLANT SCI, V4, DOI 10.3389/fpls.2013.00247
   VANLOO J, 1995, CRIT REV FOOD SCI, V35, P525, DOI 10.1080/10408399509527714
   Vilà L, 2008, HEPATOLOGY, V48, P1506, DOI 10.1002/hep.22523
   Viollet B, 2006, J PHYSIOL-LONDON, V574, P41, DOI 10.1113/jphysiol.2006.108506
   Vogt L, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0068367
   Waldrop ME, 2014, J FOOD SCI, V79, pS1782, DOI 10.1111/1750-3841.12575
   Wei YR, 2007, J NUTR BIOCHEM, V18, P1, DOI 10.1016/j.jnutbio.2006.03.013
   White JS, 2013, ADV NUTR, V4, P246, DOI 10.3945/an.112.003137
   Wu TY, 2004, AM J CLIN NUTR, V80, P1043, DOI 10.1093/ajcn/80.4.1043
NR 79
TC 25
Z9 25
U1 1
U2 67
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0921-9668
EI 1573-9104
J9 PLANT FOOD HUM NUTR
JI Plant Food Hum. Nutr.
PD SEP
PY 2015
VL 70
IS 3
BP 227
EP 237
DI 10.1007/s11130-015-0485-6
PG 11
WC Plant Sciences; Chemistry, Applied; Food Science & Technology; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Chemistry; Food Science & Technology; Nutrition &
   Dietetics
GA CP5TX
UT WOS:000359948600001
PM 25904233
DA 2025-06-11
ER

PT J
AU Belgardt, BF
   Mauer, J
   Brüning, JC
AF Belgardt, Bengt F.
   Mauer, Jan
   Bruening, Jens C.
TI Novel roles for JNK1 in metabolism
SO AGING-US
LA English
DT Article
DE JNK1; obesity; insulin resistance; CNS
ID ENDOPLASMIC-RETICULUM STRESS; N-TERMINAL KINASE; INDUCED
   INSULIN-RESISTANCE; REGULATES LIFE-SPAN; GROWTH-HORMONE;
   CAENORHABDITIS-ELEGANS; TRANSCRIPTION FACTORS; GLUCOSE-PRODUCTION;
   LEPTIN RESISTANCE; ADIPOSE-TISSUE
AB Activation of stress-kinase signaling has recently been recognized as an important pathophysiological mechanism in the development of diet-induced obesity, type 2 diabetes mellitus and other aging-related pathologies. Here, c-Jun N-terminal Kinase (JNK) 1 knockout mice have been shown to exhibit protection from diet-induced obesity, glucose intolerance, and insulin resistance. Nonetheless, the tissue-specific role of JNK1-activation in the development of the metabolic syndrome has been poorly defined so far. Recently, it was demonstrated that JNK1 signaling plays a crucial role in the central nervous system (CNS) and in the pituitary to control systemic glucose and lipid metabolism partially through regulation of hormones involved in growth and energy expenditure.
C1 [Belgardt, Bengt F.; Mauer, Jan; Bruening, Jens C.] Univ Cologne, Dept Internal Med 2, Cologne Excellence Cluster Cellular Stress Respon, Ctr Mol Med,CMMC,Inst Genet,Dept Mouse Genet & Me, D-50674 Cologne, Germany.
   [Belgardt, Bengt F.; Mauer, Jan; Bruening, Jens C.] Max Planck Inst Biol Ageing, D-50674 Cologne, Germany.
C3 University of Cologne; Max Planck Society
RP Brüning, JC (corresponding author), Univ Cologne, Dept Internal Med 2, Cologne Excellence Cluster Cellular Stress Respon, Ctr Mol Med,CMMC,Inst Genet,Dept Mouse Genet & Me, D-50674 Cologne, Germany.
EM jens.bruening@uni-koeln.de
OI Mauer, Jan/0000-0002-0189-5876; Belgardt,
   Bengt-Frederik/0000-0003-4537-9002
FU CMMC (TV2); EU [LSHM-CT-2003-503041]; Fritz Thyssen Stiftung
   [Az.10.04.1.153/Az.10.06.2.175]; EFSD/Lilly European Diabetes Research
   Programme; DFG [Br. 1492/7-1]
FX We apologize to all colleagues whose important contribution could not be
   cited due to space limitations. This work was supported by grants from
   the CMMC (TV2) and the EU (LSHM-CT-2003-503041) to J.C.B., the Fritz
   Thyssen Stiftung (Az.10.04.1.153/Az.10.06.2.175) to J.C.B., the
   EFSD/Lilly European Diabetes Research Programme to J.C.B., and the DFG
   (Br. 1492/7-1) to J.C.B.
CR Arkan MC, 2005, NAT MED, V11, P191, DOI 10.1038/nm1185
   Belgardt BF, 2008, CELL METAB, V7, P291, DOI 10.1016/j.cmet.2008.01.006
   Belgardt BF, 2010, P NATL ACAD SCI USA, V107, P6028, DOI 10.1073/pnas.1001796107
   Belgardt BF, 2009, J PHYSIOL-LONDON, V587, P5305, DOI 10.1113/jphysiol.2009.179192
   Bonkowski MS, 2006, P NATL ACAD SCI USA, V103, P7901, DOI 10.1073/pnas.0600161103
   Brüning JC, 2000, SCIENCE, V289, P2122, DOI 10.1126/science.289.5487.2122
   Clancy DJ, 2001, SCIENCE, V292, P104, DOI 10.1126/science.1057991
   Copps KD, 2010, CELL METAB, V11, P84, DOI 10.1016/j.cmet.2009.11.003
   Coschigano KT, 2003, ENDOCRINOLOGY, V144, P3799, DOI 10.1210/en.2003-0374
   De Souza CT, 2005, ENDOCRINOLOGY, V146, P4192, DOI 10.1210/en.2004-1520
   Dominici FP, 2002, J ENDOCRINOL, V173, P81, DOI 10.1677/joe.0.1730081
   Flurkey K, 2001, P NATL ACAD SCI USA, V98, P6736, DOI 10.1073/pnas.111158898
   Fontana L, 2010, SCIENCE, V328, P321, DOI 10.1126/science.1172539
   FRIEDMAN DB, 1988, GENETICS, V118, P75
   Giustina A, 2008, ENDOCR REV, V29, P535, DOI 10.1210/er.2007-0036
   Gleiberman AS, 2008, P NATL ACAD SCI USA, V105, P6332, DOI 10.1073/pnas.0801644105
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Holzenberger M, 2003, NATURE, V421, P182, DOI 10.1038/nature01298
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   Hotamisligil GS, 1996, SCIENCE, V271, P665, DOI 10.1126/science.271.5249.665
   Huang HJ, 2007, J CELL SCI, V120, P2479, DOI 10.1242/jcs.001222
   KAHN CR, 1994, DIABETES, V43, P1066, DOI 10.2337/diab.43.8.1066
   KLASS MR, 1983, MECH AGEING DEV, V22, P279, DOI 10.1016/0047-6374(83)90082-9
   Kleinridders A, 2009, CELL METAB, V10, P249, DOI 10.1016/j.cmet.2009.08.013
   Koch L, 2008, J CLIN INVEST, V118, P2132, DOI 10.1172/JCI31073
   Könner AC, 2007, CELL METAB, V5, P438, DOI 10.1016/j.cmet.2007.05.004
   Obici S, 2002, NAT MED, V8, P1376, DOI 10.1038/nm798
   Oh SW, 2005, P NATL ACAD SCI USA, V102, P4494, DOI 10.1073/pnas.0500749102
   Ozcan L, 2009, CELL METAB, V9, P35, DOI 10.1016/j.cmet.2008.12.004
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Partridge L, 2008, ONCOGENE, V27, P2351, DOI 10.1038/onc.2008.28
   Plum L, 2006, J CLIN INVEST, V116, P1761, DOI 10.1172/JCI29063
   Prada PO, 2005, ENDOCRINOLOGY, V146, P1576, DOI 10.1210/en.2004-0767
   Sabio G, 2008, SCIENCE, V322, P1539, DOI 10.1126/science.1160794
   Sabio G, 2010, GENE DEV, V24, P256, DOI 10.1101/gad.1878510
   Sabio G, 2010, MOL CELL BIOL, V30, P106, DOI 10.1128/MCB.01162-09
   Sabio G, 2009, CELL METAB, V10, P491, DOI 10.1016/j.cmet.2009.09.007
   Unger EK, 2010, ENDOCRINOLOGY, V151, P671, DOI 10.1210/en.2009-0711
   Wang MC, 2005, CELL, V121, P115, DOI 10.1016/j.cell.2005.02.030
   Wellen KE, 2003, J CLIN INVEST, V112, P1785, DOI 10.1172/JCI20514
   WHITE MF, SCIENCE, V302, P1710
   Zhang XQ, 2008, CELL, V135, P61, DOI 10.1016/j.cell.2008.07.043
NR 42
TC 28
Z9 31
U1 1
U2 4
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD SEP
PY 2010
VL 2
IS 9
BP 621
EP 626
DI 10.18632/aging.100192
PG 6
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA 657VR
UT WOS:000282447100012
PM 20834068
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Surma, S
   Sahebkar, A
   Urbanski, J
   Penson, PE
   Banach, M
AF Surma, Stanislaw
   Sahebkar, Amirhossein
   Urbanski, Jakub
   Penson, Peter E.
   Banach, Maciej
TI Curcumin-The Nutraceutical With Pleiotropic Effects? Which
   Cardiometabolic Subjects Might Benefit the Most?
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE curcumin; cardiovascular risk; cardiovascular disease; treatment;
   prevention
ID FATTY LIVER-DISEASE; TYPE-2 DIABETES-MELLITUS; ACUTE
   MYOCARDIAL-INFARCTION; DOUBLE-BLIND; METABOLIC SYNDROME; NANO-CURCUMIN;
   ORAL BIOAVAILABILITY; CARDIOVASCULAR-DISEASES; PHYTOSOMAL CURCUMIN;
   CONTROLLED-TRIAL
AB Despite continuous advances in pharmacotherapy, atherosclerotic cardiovascular disease remains the world's leading killer. Atherosclerosis relates not only to an increased level of cholesterol, but involves the development of atherosclerotic plaques, which are formed as a result of processes including inflammation and oxidative stress. Therefore, in addition to the classical risk factors for ASCVD (such as type 2 diabetes, overweight, obesity, hypertension and metabolic syndrome), residual risk factors such as inflammation and oxidative stress should also be reduced. The most important intervention in ASCVD is prevention, which includes promoting a healthy diet based on products of natural origin. Curcumin, which is often present in the diet, has been demonstrate to confer several benefits to health. It has been shown in numerous clinical trials that curcumin exhibited anti-diabetic, lipid-lowering, antihypertensive, antioxidant and anti-inflammatory effects, as well as promoting weight loss. All this means that curcumin has a comprehensive impact on the most important risk factors of ASCVD and may be a beneficial support in the treatment of these diseases. Recently, it has also been shown that curcumin may have a beneficial effect on the course of SARS-CoV-2 infection and might be helpful in the prevention of long-COVID complications. The aim of this review is to summarize the current knowledge regarding the safety and efficacy of curcumin in the prevention and treatment of cardiometabolic diseases.
C1 [Surma, Stanislaw] Med Univ Silesia, Fac Med Sci Katowice, Katowice, Poland.
   [Surma, Stanislaw] Polish Soc Hypertens, Club Young Hypertensiologists, Gdansk, Poland.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Neurogenic Inflammat Res Ctr, Mashhad, Iran.
   [Urbanski, Jakub] NomiBiotech Corp, Zlotniki, Poland.
   [Penson, Peter E.] Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Clin Pharm, Therapeut Res Grp, Liverpool, England.
   [Penson, Peter E.] Liverpool Ctr Cardiovasc Sci, Liverpool, England.
   [Banach, Maciej] Med Univ Lodz, Dept Prevent Cardiol & Lipidol, Lodz, Poland.
   [Banach, Maciej] Univ Zielona Gora, Cardiovasc Res Ctr, Zielona Gora, Poland.
   [Banach, Maciej] Polish Mothers Mem Hosp Res Inst PMMHRI, Dept Cardiol & Adult Congenital Heart Dis, Lodz, Poland.
C3 Medical University of Silesia; Mashhad University of Medical Sciences;
   Mashhad University of Medical Sciences; Liverpool John Moores
   University; Medical University Lodz; University of Zielona Gora
RP Banach, M (corresponding author), Med Univ Lodz, Dept Prevent Cardiol & Lipidol, Lodz, Poland.; Banach, M (corresponding author), Univ Zielona Gora, Cardiovasc Res Ctr, Zielona Gora, Poland.; Banach, M (corresponding author), Polish Mothers Mem Hosp Res Inst PMMHRI, Dept Cardiol & Adult Congenital Heart Dis, Lodz, Poland.
EM maciej.banach@umed.lodz.pl
RI Sahebkar, Amirhossein/B-5124-2018; Surma, Stanisław/HLX-0557-2023;
   Banach, Maciej/A-1271-2009; Penson, Peter/E-5353-2010
OI Penson, Peter/0000-0001-6763-1489; Surma, Stanislaw/0000-0001-8073-6664
CR Abdalla SM, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.18150
   Abdelmoaty AAA, 2022, ACTA PHARMACOL SIN, V43, P446, DOI 10.1038/s41401-021-00642-3
   Adibian M, 2019, PHYTOTHER RES, V33, P1374, DOI 10.1002/ptr.6328
   Afshar GV, 2020, IRAN J KIDNEY DIS, V14, P52
   Alidadi M, 2021, ADV EXP MED BIOL, V1308, P1, DOI 10.1007/978-3-030-64872-5_1
   Altobelli E, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020404
   Altunay N, 2020, FOOD CHEM, V310, DOI 10.1016/j.foodchem.2019.125933
   Alwi Idrus, 2008, Acta Med Indones, V40, P201
   Anand P, 2007, MOL PHARMACEUT, V4, P807, DOI 10.1021/mp700113r
   [Anonymous], 2021, LANCET GASTROENTEROL, V6, P411, DOI 10.1016/S2468-1253(21)00143-6
   Antony B, 2008, INDIAN J PHARM SCI, V70, P445, DOI 10.4103/0250-474X.44591
   Asadi S, 2020, PHYTOTHER RES, V34, P896, DOI 10.1002/ptr.6571
   Asadi S, 2019, COMPLEMENT THER MED, V43, P253, DOI 10.1016/j.ctim.2019.02.014
   Ashtary-Larky D, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10071015
   Atkin SL, 2017, PHYTOTHER RES, V31, P1836, DOI 10.1002/ptr.5905
   Averna M, 2021, ATHEROSCLEROSIS, V325, P99, DOI 10.1016/j.atherosclerosis.2021.03.039
   Azhdari M, 2019, PHYTOTHER RES, V33, P1289, DOI 10.1002/ptr.6323
   Baell J, 2014, NATURE, V513, P481, DOI 10.1038/513481a
   Banach M, 2021, ARCH MED SCI, V17, P1447, DOI 10.5114/aoms/141941
   Banach M, 2019, ATHEROSCLEROSIS SUPP, V39, pE1, DOI 10.1016/j.atherosclerosissup.2019.08.023
   Bateni Z, 2021, PHYTOTHER RES, V35, P3945, DOI 10.1002/ptr.7109
   Baziar N, 2020, PHYTOTHER RES, V34, P464, DOI 10.1002/ptr.6542
   Campbell MS, 2019, NUTRITION, V62, P135, DOI 10.1016/j.nut.2019.01.002
   Campbell MS, 2017, J FUNCT FOODS, V29, P154, DOI 10.1016/j.jff.2016.12.013
   Cheng AL, 2001, ANTICANCER RES, V21, P2895
   Chuengsamarn S, 2014, J NUTR BIOCHEM, V25, P144, DOI 10.1016/j.jnutbio.2013.09.013
   Chuengsamarn S, 2012, DIABETES CARE, V35, P2121, DOI 10.2337/dc12-0116
   Cicero AFG, 2017, NUTR REV, V75, P731, DOI [10.5114/aoms.2017.69326, 10.1093/nutrit/nux047]
   Clark CCT, 2019, DIABETES METAB SYND, V13, P2819, DOI 10.1016/j.dsx.2019.07.045
   Cuomo J, 2011, J NAT PROD, V74, P664, DOI 10.1021/np1007262
   Dalidowska I, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22042020
   Dei Cas M, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092147
   Derosa G, 2016, PHARMACOL RES, V111, P394, DOI 10.1016/j.phrs.2016.07.004
   Di Pierro F, 2015, EUR REV MED PHARMACO, V19, P4195
   Di Zanni E, 2012, NEUROBIOL DIS, V45, P508, DOI 10.1016/j.nbd.2011.09.007
   Esmaily H, 2015, CHIN J INTEGR MED, V21, P332, DOI 10.1007/s11655-015-2160-z
   Ferguson JJA, 2021, NUTR REV, V79, P1043, DOI 10.1093/nutrit/nuaa114
   Ferguson JJA, 2018, METABOLISM, V82, P22, DOI 10.1016/j.metabol.2017.12.009
   Funamoto M, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/8208237
   Furia T.E., 1973, CRC Handbook of Food Additives, V1
   Ganjali S, 2017, PHARMACOL RES, V119, P208, DOI 10.1016/j.phrs.2017.02.008
   Ganjali S, 2014, SCI WORLD J, DOI 10.1155/2014/898361
   Gorabi AM, 2022, PHYTOTHER RES, V36, P85, DOI 10.1002/ptr.7284
   Gorabi AM, 2021, CYTOKINE, V143, DOI 10.1016/j.cyto.2021.155541
   Gorgani L, 2017, COMPR REV FOOD SCI F, V16, P124, DOI 10.1111/1541-4337.12246
   Gota VS, 2010, J AGR FOOD CHEM, V58, P2095, DOI 10.1021/jf9024807
   Guthold R, 2020, LANCET CHILD ADOLESC, V4, P23, DOI 10.1016/S2352-4642(19)30323-2
   Hadi A, 2019, PHARMACOL RES, V150, DOI 10.1016/j.phrs.2019.104505
   Hirode G, 2020, JAMA-J AM MED ASSOC, V323, P2526, DOI 10.1001/jama.2020.4501
   Hodaei H, 2019, DIABETOL METAB SYNDR, V11, DOI 10.1186/s13098-019-0437-7
   Huang J, 2019, J HUM NUTR DIET, V32, P591, DOI 10.1111/jhn.12648
   Jäger R, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-11
   Jamilian M, 2020, CLIN NUTR ESPEN, V36, P128, DOI 10.1016/j.clnesp.2020.01.005
   Jazayeri-Tehrani SA, 2019, NUTR METAB, V16, DOI 10.1186/s12986-019-0331-1
   Jennings MR, 2020, MICROORGANISMS, V8, DOI 10.3390/microorganisms8101524
   Karandish M, 2021, PHYTOTHER RES, V35, P4377, DOI 10.1002/ptr.7136
   Kelly T, 2008, INT J OBESITY, V32, P1431, DOI 10.1038/ijo.2008.102
   Khajuria Annu, 1998, Indian Journal of Experimental Biology, V36, P46
   Komiyama M, 2021, EUR CARDIOL REV, V16, DOI 10.15420/ecr.2021.10
   Kotha RR, 2019, MOLECULES, V24, DOI 10.3390/molecules24162930
   Lao Christopher D, 2006, BMC Complement Altern Med, V6, P10, DOI 10.1186/1472-6882-6-10
   Lee S, 2021, NUTRIENTS, V13, DOI 10.3390/nu13082797
   Lewek J, 2021, ARCH MED SCI, V17, P818, DOI 10.5114/aoms/134211
   Li H, 2020, BIOTECHNOL ADV, V38, DOI 10.1016/j.biotechadv.2019.01.010
   Li ZY, 2021, FRONT PUBLIC HEALTH, V9, DOI 10.3389/fpubh.2021.559751
   Lin XL, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-71908-9
   Liu WD, 2016, J DRUG TARGET, V24, P694, DOI 10.3109/1061186X.2016.1157883
   Ma ZW, 2019, J CONTROL RELEASE, V316, P359, DOI 10.1016/j.jconrel.2019.10.053
   Mahdavi Atena, 2021, Adv Exp Med Biol, V1291, P139, DOI 10.1007/978-3-030-56153-6_8
   Mangolim CS, 2014, FOOD CHEM, V153, P361, DOI 10.1016/j.foodchem.2013.12.067
   Marcolino VA, 2011, J AGR FOOD CHEM, V59, P3348, DOI 10.1021/jf104223k
   Martins RM, 2013, FOOD RES INT, V50, P657, DOI 10.1016/j.foodres.2011.06.030
   Marton LT, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.669448
   Milobedzka J, 1910, BER DTSCH CHEM GES, V43, P2163, DOI 10.1002/cber.191004302168
   Mirhafez SR, 2021, ADV EXP MED BIOL, V1308, P25, DOI 10.1007/978-3-030-64872-5_3
   Mirhafez SR, 2019, J GASTROINTEST LIVER, V28, P183, DOI 10.15403/jgld-179
   Mirzabeigi P, 2015, IRAN J PHARM RES, V14, P479
   Mohammadi Elahe, 2021, Adv Exp Med Biol, V1291, P151, DOI 10.1007/978-3-030-56153-6_9
   Mohammed ES, 2021, ARCH MED SCI, V17, P218, DOI 10.5114/aoms.2020.93739
   Mokhtari M, 2021, PHYTOTHER RES, V35, P2099, DOI 10.1002/ptr.6957
   Mousavi SM, 2020, CRIT REV FOOD SCI, V60, P171, DOI 10.1080/10408398.2018.1517724
   Na LX, 2014, BIOMED ENVIRON SCI, V27, P902, DOI 10.3967/bes2014.127
   Na LX, 2013, MOL NUTR FOOD RES, V57, P1569, DOI 10.1002/mnfr.201200131
   Panahi Y, 2018, DRUG RES, V68, P403, DOI 10.1055/s-0044-101752
   Panahi Y, 2017, CURR CLIN PHARMACOL, V12, P253, DOI 10.2174/1574884713666180104095641
   Panahi Y, 2017, COMPLEMENT THER MED, V33, P1, DOI 10.1016/j.ctim.2017.05.006
   Panahi Y, 2017, DRUG RES, V67, P244, DOI 10.1055/s-0043-100019
   Panahi Y, 2017, INFLAMMOPHARMACOLOGY, V25, P25, DOI 10.1007/s10787-016-0301-4
   Panahi Y, 2016, J CARDIOVASC PHARM, V68, P223, DOI 10.1097/FJC.0000000000000406
   Panahi Y, 2016, NUTRITION, V32, P1116, DOI 10.1016/j.nut.2016.03.018
   Panahi Y, 2016, BIOMED PHARMACOTHER, V82, P578, DOI 10.1016/j.biopha.2016.05.037
   Panahi Y, 2015, CLIN NUTR, V34, P1101, DOI 10.1016/j.clnu.2014.12.019
   Pirillo A, 2021, NAT REV CARDIOL, V18, P689, DOI 10.1038/s41569-021-00541-4
   Pivari F, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081837
   Pulido-Moran M, 2016, MOLECULES, V21, DOI 10.3390/molecules21030264
   Purpura M, 2018, EUR J NUTR, V57, P929, DOI 10.1007/s00394-016-1376-9
   Qin S, 2018, NUTR RES, V60, P1, DOI 10.1016/j.nutres.2018.08.003
   Qin S, 2017, NUTR J, V16, DOI 10.1186/s12937-017-0293-y
   Rahimi HR, 2016, AVICENNA J PHYTOMEDI, V6, P567
   Rahmani S, 2016, PHYTOTHER RES, V30, P1540, DOI 10.1002/ptr.5659
   Rosengren A, 2019, LANCET GLOB HEALTH, V7, pE748, DOI 10.1016/S2214-109X(19)30045-2
   Roth GA, 2020, J AM COLL CARDIOL, V76, P2982, DOI 10.1016/j.jacc.2020.11.010
   Ruscica M, 2021, PROG CARDIOVASC DIS, V67, P40, DOI 10.1016/j.pcad.2021.06.010
   Ryan JL, 2013, RADIAT RES, V180, P34, DOI 10.1667/RR3255.1
   Saadati S, 2019, EUR J CLIN NUTR, V73, P441, DOI 10.1038/s41430-018-0382-9
   Safari Zahra, 2021, Adv Exp Med Biol, V1291, P121, DOI 10.1007/978-3-030-56153-6_7
   Sahebkar A, 2017, J CACHEXIA SARCOPENI, V8, P19, DOI 10.1002/jcsm.12140
   Saraf-Bank S, 2019, SAO PAULO MED J, V137, P414, DOI 10.1590/1516-3180.2018.0454120419
   Saraf-Bank S, 2019, PHYTOTHER RES, V33, P2015, DOI 10.1002/ptr.6370
   Jiménez-Osorio AS, 2016, J RENAL NUTR, V26, P237, DOI 10.1053/j.jrn.2016.01.013
   Sasaki H, 2011, BIOL PHARM BULL, V34, P660, DOI 10.1248/bpb.34.660
   Sathiyakumar V, 2018, TRENDS PHARMACOL SCI, V39, P733, DOI 10.1016/j.tips.2018.06.001
   Schiborr C, 2014, MOL NUTR FOOD RES, V58, P516, DOI 10.1002/mnfr.201300724
   Shafabakhsh R, 2020, CLIN NUTR ESPEN, V40, P77, DOI 10.1016/j.clnesp.2020.09.029
   Shafabakhsh R, 2020, IRAN J KIDNEY DIS, V14, P290
   Silalahi T, 2021, INT J ANGIOL, V30, P132, DOI 10.1055/s-0040-1720969
   Simental-Mendía LE, 2019, OBES RES CLIN PRACT, V13, P340, DOI 10.1016/j.orcp.2019.04.003
   Simental-Mendía LE, 2019, CRIT REV FOOD SCI, V59, P1178, DOI 10.1080/10408398.2017.1396201
   Singh L, 2021, MOLECULES, V26, DOI 10.3390/molecules26134036
   Sohaei S, 2019, COMPLEMENT THER MED, V47, DOI 10.1016/j.ctim.2019.102201
   Soleimani V, 2018, PHYTOTHER RES, V32, P985, DOI 10.1002/ptr.6054
   Srinivasan A, 2019, PHYTOTHER RES, V33, P1898, DOI 10.1002/ptr.6381
   Stojanovic-Radic Z, 2019, APPL SCI-BASEL, V9, DOI 10.3390/app9204270
   Tabaee S, 2021, ADV EXP MED BIOL, V1328, P199, DOI 10.1007/978-3-030-73234-9_13
   Tabrizi R, 2019, PHYTOTHER RES, V33, P253, DOI 10.1002/ptr.6226
   Tabrizi R, 2018, CURR PHARM DESIGN, V24, P3184, DOI 10.2174/1381612824666180828162053
   Thota RN, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041032
   Thota RN, 2019, LIPIDS HEALTH DIS, V18, DOI 10.1186/s12944-019-0967-x
   Thota RN, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-32032-x
   Vahedian-Azimi A, 2022, NUTRIENTS, V14, DOI 10.3390/nu14020256
   Vanaie A, 2019, J RES MED SCI, V24, DOI 10.4103/jrms.JRMS_1055_18
   Vareed SK, 2008, CANCER EPIDEM BIOMAR, V17, P1411, DOI 10.1158/1055-9965.EPI-07-2693
   de Melo ISV, 2018, PHARMACOL RES, V128, P137, DOI 10.1016/j.phrs.2017.09.010
   Wang YJ, 1997, J PHARMACEUT BIOMED, V15, P1867, DOI 10.1016/S0731-7085(96)02024-9
   Williams R, 2020, DIABETES RES CLIN PR, V162, DOI 10.1016/j.diabres.2020.108072
   Wongcharoen W, 2012, AM J CARDIOL, V110, P40, DOI 10.1016/j.amjcard.2012.02.043
   Yang H, 2015, EXP CLIN ENDOCR DIAB, V123, P360, DOI 10.1055/s-0035-1545345
   Yuan F, 2019, ADV NUTR, V10, P791, DOI 10.1093/advances/nmz021
   Zahedipour F, 2020, PHYTOTHER RES, V34, P2911, DOI 10.1002/ptr.6738
   Zhang TQ, 2021, EVID-BASED COMPL ALT, V2021, DOI 10.1155/2021/4471944
   Zheng ZH, 2020, J INFECTION, V81, pE16, DOI 10.1016/j.jinf.2020.04.021
NR 141
TC 18
Z9 19
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD MAY 17
PY 2022
VL 9
AR 865497
DI 10.3389/fnut.2022.865497
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1V5NC
UT WOS:000806135100001
PM 35662932
OA gold, Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Hosoyamada, Y
   Yamada, M
AF Hosoyamada, Yasue
   Yamada, Masako
TI Effects of Dietary Fish Oil and Apple Polyphenol on the Concentration
   Serum Lipids and Excretion of Fecal Bile Acids in Rats
SO JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
LA English
DT Article
DE fish oil; apple pholyphenol; fecal bile acids; rat
ID POLYUNSATURATED FATTY-ACIDS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   IN-VITRO; DOCOSAHEXAENOIC ACID; PANCREATIC LIPASE; TEA POLYPHENOLS;
   CHOLESTEROL; ABSORPTION; JAPANESE
AB We studied the effects of fish oil and apple polyphenol combined with a high cholesterol diet in rats, and assessed serum and liver lipids concentrations, serum oxidative stress and fecal bile acid excretion. Young male rats were fed a diet containing the control (Control), apple polyphenol (AP), fish oil (FO) or fish oil + apple polyphenol (FO +AP) for 4 wk. The control diet contained a lard component. Posterior abdominal wall fat and testicle peripheral fat weights decreased in the FO +AP group compared to the AP group. The concentration of total cholesterol in the serum and liver decreased in the FO group and the FO +AP group compared to the Control and the AP groups. The concentration of adiponectin and biological antioxidant potential in the serum increased in the FO group compared to the other groups. The diacron-reactive oxygen metabolites in serum decreased in the FO group and the FO +AP group compared to the Control and the AP groups. The bile acid excretion in feces increased in the AP group, the FO group and the FO +AP group compared to the Control group. These results suggested that the combination of fish oil and apple poly phenol in the diet improved serum and liver lipids, which should assist in the prevention and improvement of metabolic syndrome.
C1 [Hosoyamada, Yasue; Yamada, Masako] Chiba Prefectural Univ Hlth Sci, Fac Hlth Care Sci, Dept Nutr, Mihama Ku, 2-10-1 Wakaba, Chiba, Chiba 2610014, Japan.
RP Hosoyamada, Y (corresponding author), Chiba Prefectural Univ Hlth Sci, Fac Hlth Care Sci, Dept Nutr, Mihama Ku, 2-10-1 Wakaba, Chiba, Chiba 2610014, Japan.
EM yasue.hosoyamada@cpuhs.ac.jp
CR Azuma T, 2013, J JPN SOC FOOD SCI, V60, P184, DOI 10.3136/nskkk.60.184
   Birch EE, 2010, AM J CLIN NUTR, V91, P848, DOI 10.3945/ajcn.2009.28557
   BRONSGEESTSCHOUTE HC, 1981, AM J CLIN NUTR, V34, P1752, DOI 10.1093/ajcn/34.9.1752
   Demonty I, 2009, J NUTR, V139, P271, DOI 10.3945/jn.108.095125
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Garg ML, 1998, J CLIN BIOCHEM NUTR, V24, P23
   Gent CM, 1979, LANCET, P1249
   Iso H, 2006, CIRCULATION, V113, P195, DOI 10.1161/CIRCULATIONAHA.105.581355
   Jay D, 2006, FREE RADICAL BIO MED, V40, P183, DOI 10.1016/j.freeradbiomed.2005.06.018
   Juhel C, 2000, J NUTR BIOCHEM, V11, P45, DOI 10.1016/S0955-2863(99)00070-4
   Kanamoto Y, 2011, J AGR FOOD CHEM, V59, P8985, DOI 10.1021/jf201471p
   Kim M, 2015, SCI REP-UK, V5, DOI 10.1038/srep18013
   Kopelman PG, 2000, NATURE, V404, P635, DOI 10.1038/35007508
   Lin XB, 2011, LIPIDS, V46, P701, DOI 10.1007/s11745-011-3560-2
   Mulvihill EE, 2009, DIABETES, V58, P2198, DOI 10.2337/db09-0634
   Murase T, 2011, AM J PHYSIOL-ENDOC M, V300, pE122, DOI 10.1152/ajpendo.00441.2010
   Murdolo G, 2013, FREE RADICAL BIO MED, V65, P811, DOI 10.1016/j.freeradbiomed.2013.08.007
   Nagao K, 2008, PROG LIPID RES, V47, P127, DOI 10.1016/j.plipres.2007.12.002
   Nagasako-Akazome Yoko, 2007, J Oleo Sci, V56, P417
   Nakagawa K, 1999, J AGR FOOD CHEM, V47, P3967, DOI 10.1021/jf981195l
   Nakai M, 2005, J AGR FOOD CHEM, V53, P4593, DOI 10.1021/jf047814+
   Nakazato K, 2006, EXP ANIM TOKYO, V55, P383, DOI 10.1538/expanim.55.383
   Ogino Y, 2007, LIPIDS, V42, P151, DOI 10.1007/s11745-006-3008-2
   Ohta Y., 2006, Journal of Oleo Science, V55, P305
   Osada K., 2006, Journal of Oleo Science, V55, P79
   Osada K, 2006, LIPIDS, V41, P133, DOI 10.1007/s11745-006-5081-y
   Rossi AS, 2005, AM J PHYSIOL-REG I, V289, pR486, DOI 10.1152/ajpregu.00846.2004
   Shishikura Y, 2006, J AGR FOOD CHEM, V54, P1906, DOI 10.1021/jf051988p
   SINGER P, 1990, ATHEROSCLEROSIS, V83, P167, DOI 10.1016/0021-9150(90)90162-C
   Sugiyama H, 2007, J AGR FOOD CHEM, V55, P4604, DOI 10.1021/jf070569k
   Suzuki K, 2013, BIOSCI BIOTECH BIOCH, V77, P1792, DOI 10.1271/bbb.130380
   Williamson G, 2005, FREE RADICAL RES, V39, P457, DOI 10.1080/10715760500053610
   WONG S, 1985, METABOLISM, V34, P900, DOI 10.1016/0026-0495(85)90135-0
   Yamagishi K, 2008, J AM COLL CARDIOL, V52, P988, DOI 10.1016/j.jacc.2008.06.018
NR 35
TC 13
Z9 15
U1 0
U2 13
PU CENTER ACADEMIC PUBL JAPAN
PI TOKYO
PA 2-4-16 YAYOI, BUNKYO-KU, TOKYO, 113-0032, JAPAN
SN 0301-4800
EI 1881-7742
J9 J NUTR SCI VITAMINOL
JI J. Nutr. Sci. Vitaminol.
PD FEB
PY 2017
VL 63
IS 1
BP 21
EP 27
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EN0TW
UT WOS:000395724400004
PM 28367922
OA gold
DA 2025-06-11
ER

PT J
AU Cho, KI
   Kim, BH
   Je, HG
   Jang, JS
   Park, YH
AF Cho, Kyoung Im
   Kim, Bo Hyun
   Je, Hyung Gon
   Jang, Jae Sik
   Park, Yong Hyun
TI Gender-Specific Associations between Socioeconomic Status and
   Psychological Factors and Metabolic Syndrome in the Korean Population:
   Findings from the 2013 Korean National Health and Nutrition Examination
   Survey
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; PREVALENCE; OBESITY; ADULTS; SEX
AB We aimed to assess the gender-specific associations between psychological factors and socioeconomic status (SES) and metabolic syndrome (MetS) in Korean adults. We examined 4,689 Korean adults aged 20-79 years who participated in the 2013 Korean National Health Examination and Nutrition Survey. With regard to SES, occupation status (none, manual, and nonmanual), marital status (single, married, divorced, and widowed), and psychological factors (detection of stress, depressive symptoms, and suicidal thoughts) were determined via questionnaires. Compared with married men, single and divorced men exhibited ORs (95% confidence interval [CIs]) for MetS of 0.45 (0.31-0.65) and 1.61 (1.02-2.55), respectively, after adjusting for covariates. However, this association was not significant in women. Compared with those in the lowest household income group and least educated group in women, the ORs for MetS in the highest income group and the most educated group were 0.63 (CI 0.46-0.86) and 0.46 (CI 0.32-0.67), respectively. Suicidal thoughts in men (OR 1.64, CI 1.03-2.61) and perceived stress in women (OR 1.26, CI 1.01-1.59) were associated with MetS. In this study, MetS has gender-specific associations with lower SES and psychological factors. Thus, gender-specific public health interventions based on SES and psychological factors are needed to prevent and treat MetS and reduce additional cardiovascular disease risk.
C1 [Cho, Kyoung Im] Kosin Univ, Sch Med, Dept Internal Med, 34 Amnam Dong, Busan 602702, South Korea.
   [Kim, Bo Hyun] Pusan Natl Univ Hosp & Biomed Res Inst, Dept Internal Med, 179 Gudeok Ro, Busan 602739, South Korea.
   [Je, Hyung Gon] Pusan Natl Univ, Yangsan Hosp, Res Inst Convergence Biomed Sci & Technol, Dept Cardiovasc & Thorac Surg, Yangsan 626770, South Korea.
   [Jang, Jae Sik] Univ Inje, Coll Med, Busan Paik Hosp, Dept Internal Med, Busan 614735, South Korea.
   [Park, Yong Hyun] Pusan Natl Univ, Yangsan Hosp, Dept Internal Med, Yangsan 626770, South Korea.
C3 Pusan National University; Pusan National University Hospital; Inje
   University; Pusan National University; Pusan National University
   Hospital
RP Kim, BH (corresponding author), Pusan Natl Univ Hosp & Biomed Res Inst, Dept Internal Med, 179 Gudeok Ro, Busan 602739, South Korea.
EM pons71@hanmail.net
RI Kim, Yun Hak/ABF-3331-2021; Cho, Young-Seok/J-5670-2012; Jang,
   Jae-Sik/B-4379-2015
OI Kim, Bo Hyun/0000-0001-9632-9457
CR Al-Daghri NM, 2014, BMC CARDIOVASC DISOR, V14, DOI [10.1186/1471-2458-14-391, 10.1186/1471-2261-14-51]
   Booth SL, 2001, NUTR REV, V59, pS21, DOI 10.1111/j.1753-4887.2001.tb06983.x
   Buckland G, 2008, PUBLIC HEALTH NUTR, V11, P1372, DOI 10.1017/S1368980008003492
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Gurka MJ, 2014, METABOLISM, V63, P218, DOI 10.1016/j.metabol.2013.10.006
   Ha KH, 2015, ENDOCRINOL METAB, V30, P142, DOI 10.3803/EnM.2015.30.2.142
   Hosseinpour-Niazi S, 2014, INT J ENDOCRINOL MET, V12, DOI 10.5812/ijem.18980
   Joh HK, 2013, OBESITY FACTS, V6, P17, DOI 10.1159/000346805
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lee SY, 2007, DIABETES RES CLIN PR, V75, P72, DOI 10.1016/j.diabres.2006.04.013
   Lidfeldt J, 2003, DIABETES OBES METAB, V5, P106, DOI 10.1046/j.1463-1326.2003.00250.x
   Lim S, 2011, DIABETES CARE, V34, P1323, DOI 10.2337/dc10-2109
   Loucks EB, 2007, ANN EPIDEMIOL, V17, P19, DOI 10.1016/j.annepidem.2006.07.002
   Minehira K, 2002, EUR J CLIN NUTR, V56, DOI 10.1038/sj.ejcn.1601645
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Park SJ, 2012, DIABETES RES CLIN PR, V96, P400, DOI 10.1016/j.diabres.2011.12.025
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Regidor E, 2004, EUR J CLIN NUTR, V58, P488, DOI 10.1038/sj.ejcn.1601835
   Russo A, 2008, EUR J CANCER, V44, P293, DOI 10.1016/j.ejca.2007.11.005
   Santos AC, 2008, BMC PUBLIC HEALTH, V8, DOI 10.1186/1471-2458-8-62
   Troxel WM, 2005, ARCH INTERN MED, V165, P1022, DOI 10.1001/archinte.165.9.1022
   Vernay M, 2013, INT J PUBLIC HEALTH, V58, P855, DOI 10.1007/s00038-013-0501-2
   Walker SE, 2012, NUTR METAB CARDIOVAS, V22, P141, DOI 10.1016/j.numecd.2010.05.006
   Wilson PWF, 2005, CIRCULATION, V112, P3066, DOI 10.1161/CIRCULATIONAHA.105.539528
NR 24
TC 25
Z9 27
U1 1
U2 4
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2016
VL 2016
AR 3973197
DI 10.1155/2016/3973197
PG 8
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA EF6MA
UT WOS:000390443900001
PM 28050556
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Arpaci, D
   Celik, SK
   Can, M
   Ermis, E
   Kuzu, F
   Kokturk, F
   Hamamcioglu, AC
   Dursun, A
   Bayraktaroglu, T
AF Arpaci, Dilek
   Celik, Sevim Karakas
   Can, Murat
   Ermis, Esra
   Kuzu, Fatih
   Kokturk, Furuzan
   Hamamcioglu, Ayse Ceylan
   Dursun, Ahmet
   Bayraktaroglu, Taner
TI Serum paraoxonase level and paraoxonase polymorphism in patients with
   acromegaly
SO REDOX REPORT
LA English
DT Article
DE Acromegaly; Paraoxonase; Polymorphism
ID CORONARY-ARTERY-DISEASE; GROWTH-FACTOR-I; Q192R POLYMORPHISM;
   RISK-FACTORS; DENSITY-LIPOPROTEIN; LIPID-PEROXIDATION; OXIDATIVE STRESS;
   DIABETES-MELLITUS; GENE; ATHEROSCLEROSIS
AB Background: Acromegalic patients have increased cardiometabolic risk factors due to an elevation of growth hormone (GH) levels. Human serum paraoxonase (PON), a high-density lipoprotein (HDL)-related enzyme, is one of the major bioscavengers and decreases the oxidation of low-density lipoprotein (LDL), a key regulator in the pathogenesis of atherosclerosis. In this study, we investigated a potential relationship between serum PON levels or PON polymorphisms and acromegaly.
   Methods: A total of 48 acromegalic patients and 44 healthy controls were included in this study. Serum GH levels, insulin-like growth factor-1 levels and lipid profiles were measured. Serum PON levels, as well as PON 1 L55M and Q192R gene polymorphisms, were examined.
   Results: No significant differences were found in terms of age, gender, presence of diabetes, serum LDL cholesterol (LDL-C), HDL-C, or triglyceride levels between the case and control groups (P > 0.05). A statistically significant difference was found in serum PON levels between the cases and controls (P = 0.007). The median serum PON level was 101 +/- 63.36 U/l in the case group and 63 +/- 60.50 U/l in the control group. There was a significant correlation between serum PON levels and IGF-1 levels (P = 0.004, r = 0.319); however, no significant differences were found in PON1 L55M and PON Q192R polymorphisms between the patients and controls (P = 0.607 and P = 0.308, respectively). In addition, no significant differences were found in serum PON levels in acromegalic patients who were and were not in remission (P = 0.385), nor between those with PON1 L55M and Q192R polymorphisms (P = 0.161 and P = 0.336, respectively).
   Conclusions: Elevated serum PON levels were detected in acromegalic patients, independently of their remission status. This suggests protective effects for cardiometabolic risk parameters.
C1 [Arpaci, Dilek; Kuzu, Fatih; Bayraktaroglu, Taner] Bulent Ecevit Univ, Dept Endocrinol & Metab, Fac Med, Kozlu, Zonguldak, Turkey.
   [Celik, Sevim Karakas] Bulent Ecevit Univ, Grad Sch Nat & Appl Sci, Dept Biol, Zonguldak, Turkey.
   [Can, Murat] Bulent Ecevit Univ, Dept Biochem, Fac Med, Zonguldak, Turkey.
   [Ermis, Esra; Dursun, Ahmet] Bulent Ecevit Univ, Fac Arts & Sci, Dept Mol Biol & Genet, Zonguldak, Turkey.
   [Kokturk, Furuzan] Bulent Ecevit Univ, Dept Biostat, Fac Med, Zonguldak, Turkey.
   [Hamamcioglu, Ayse Ceylan] Bulent Ecevit Univ, Fac Chem, Zonguldak, Turkey.
C3 Zonguldak Bulent Ecevit University; Zonguldak Bulent Ecevit University;
   Zonguldak Bulent Ecevit University; Zonguldak Bulent Ecevit University;
   Zonguldak Bulent Ecevit University; Zonguldak Bulent Ecevit University
RP Arpaci, D (corresponding author), Bulent Ecevit Univ, Dept Endocrinol & Metab, Fac Med, Kozlu, Zonguldak, Turkey.
EM drarpaci@gmail.com
RI Bayraktaroglu, Taner/Y-8182-2019; Hamamcioglu, Ayse
   Ceylan/AAG-4209-2019; Dursun, Ahmet/HGU-7580-2022; CAN,
   Murat/S-6630-2016; Ermis Akyuz, Esra/MGA-6180-2025; kuzu,
   Fatih/R-6801-2017; KARAKAS CELIK, Sevim/C-3773-2018
OI KARAKAS CELIK, Sevim/0000-0003-0505-7850; DURSUN,
   AHMET/0000-0002-7625-837X; Karakaya, Dilek/0000-0002-3603-5198; Ermis
   Akyuz, Esra/0000-0001-6233-2420
CR ADKINS S, 1993, AM J HUM GENET, V52, P598
   Akutsu H, 2010, EUR J ENDOCRINOL, V162, P879, DOI 10.1530/EJE-09-0945
   Alegría-Torres JA, 2015, ARCH MED RES, V46, P78, DOI 10.1016/j.arcmed.2014.12.001
   Altuner D, 2011, TOXICOL IND HEALTH, V27, P873, DOI 10.1177/0748233711399317
   Anagnostis P, 2013, HORM METAB RES, V45, P314, DOI 10.1055/s-0032-1323765
   Arca M, 2002, EUR J CLIN INVEST, V32, P9, DOI 10.1046/j.1365-2362.2002.00935.x
   Boero L, 2010, CLIN ENDOCRINOL, V72, P654, DOI 10.1111/j.1365-2265.2009.03685.x
   Bogazzi F, 2007, J CLIN ENDOCR METAB, V92, P4271, DOI 10.1210/jc.2007-1213
   Brown-Borg HM, 2002, EXP BIOL MED, V227, P94, DOI 10.1177/153537020222700203
   Cannavo S, 2006, J CLIN ENDOCR METAB, V91, P3766, DOI 10.1210/jc.2005-2857
   Clayton RN, 2003, ENDOCR REV, V24, P272, DOI 10.1210/er.2003-0009
   Colao A, 1997, J CLIN ENDOCR METAB, V82, P2777, DOI 10.1210/jc.82.9.2777
   Silva CMD, 2015, ENDOCRINE, V50, P749, DOI 10.1007/s12020-015-0628-4
   Ergun MA, 2011, BIOCHEM GENET, V49, P1, DOI 10.1007/s10528-010-9376-6
   Fleseriu M, 2014, ENDOCRINE, V47, P1, DOI 10.1007/s12020-013-0157-y
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   GAN KN, 1991, DRUG METAB DISPOS, V19, P100
   Garin MCB, 1997, J CLIN INVEST, V99, P62, DOI 10.1172/JCI119134
   Higashi Y, 2010, TRENDS ENDOCRIN MET, V21, P245, DOI 10.1016/j.tem.2009.12.005
   Ikeda Y, 1998, METABOLISM, V47, P598, DOI 10.1016/S0026-0495(98)90246-3
   Ito T, 2002, HUM GENET, V110, P89, DOI 10.1007/s00439-001-0654-6
   Kaman D, 2009, CELL BIOCHEM FUNCT, V27, P88, DOI 10.1002/cbf.1539
   Ko YL, 1998, ATHEROSCLEROSIS, V141, P259, DOI 10.1016/S0021-9150(98)00179-8
   La Du B.N., 1992, PHARMACOGENETICS DRU, P51
   Liberopoulos EN, 2004, PERITON DIALYSIS INT, V24, P580
   Mackness B, 1998, FEBS LETT, V423, P57, DOI 10.1016/S0014-5793(98)00064-7
   MACKNESS MI, 1995, ATHEROSCLEROSIS, V115, P243, DOI 10.1016/0021-9150(94)05524-M
   Muller G, 2007, Hamostaseologie, V27, P5
   Ng CJ, 2005, FREE RADICAL BIO MED, V38, P153, DOI 10.1016/j.freeradbiomed.2004.09.035
   Nishizawa H, 2012, GROWTH HORM IGF RES, V22, P64, DOI 10.1016/j.ghir.2012.02.001
   Osei-Hyiaman D, 2001, EUR J ENDOCRINOL, V144, P639, DOI 10.1530/eje.0.1440639
   Otsuki M, 2001, CLIN ENDOCRINOL, V54, P791, DOI 10.1046/j.1365-2265.2001.01281.x
   Ozkan C, 2015, PITUITARY, V18, P621, DOI 10.1007/s11102-014-0621-6
   PrimoParmo SL, 1996, GENOMICS, V33, P498, DOI 10.1006/geno.1996.0225
   Quillen EE, 2012, J LIPIDS, V2012, DOI 10.1155/2012/189681
   Ragonese M, 2014, ENDOCRINE, V47, P206, DOI 10.1007/s12020-013-0115-8
   Sies H., 1985, OXIDATIVE STRESS, P1, DOI DOI 10.1016/B978-0-12-642760-8.50005-3
   Succurro E, 2008, DIABETES CARE, V31, P1886, DOI 10.2337/dc08-0553
   Sukhanov S, 2015, ATHEROSCLEROSIS, V238, P313, DOI 10.1016/j.atherosclerosis.2014.12.024
   Tewthanom K, 2008, J PHARM PHARM SCI, V11, P30, DOI 10.18433/J3C885
   Yarman S, 2003, CLIN CHIM ACTA, V336, P45, DOI 10.1016/S0009-8981(03)00328-0
NR 41
TC 1
Z9 1
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1351-0002
EI 1743-2928
J9 REDOX REP
JI Redox Rep.
PY 2016
VL 21
IS 6
BP 281
EP 286
DI 10.1080/13510002.2015.1133036
PG 6
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DX7AU
UT WOS:000384538900006
PM 26863932
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Indriyati, T
   Adisasmita, AC
   Nadjib, M
   Subekti, I
   Hatma, RD
   Kosen, S
   Riyadina, W
   Purnamasari, T
AF Indriyati, Titi
   Adisasmita, Asri C.
   Nadjib, Mardiati
   Subekti, Imam
   Hatma, Ratna Djuwita
   Kosen, Soewarta
   Riyadina, Woro
   Purnamasari, Telly
TI The role of changes in metabolic syndrome status on health-related
   quality of life in Bogor City, West Java, Indonesia: A cross-sectional
   study
SO BELITUNG NURSING JOURNAL
LA English
DT Article
DE Indonesia; comorbidity; effect modification; dose-response relationship;
   health-related quality of life; metabolic syndrome; cardiovascular
   diseases
ID RISK; ADULTS
AB Background: Metabolic syndrome (MetS) is a cluster of chronic conditions, including central obesity, hypertension, impaired glucose metabolism, and dyslipidemia (low HDL, high LDL, and triglycerides). A diagnosis of MetS is made when three or more of these symptoms are present. If left unmanaged, MetS can lead to serious health complications such as cardiovascular disease and type 2 diabetes. Over time, individuals with MetS may experience a decline in their health-related quality of life (HRQoL), especially due to its chronic nature. Objective: This study aimed to evaluate the effects of changes in MetS status on HRQoL. Methods: This study employed a cross-sectional design. Secondary data from the cohort study of Non-Communicable Disease (NCD) risk factors, conducted by the Health Research and Development Agency of the Ministry of Health of the Republic of Indonesia in Bogor City, was used. Data from four follow-up periods (2011/2012 to 2017/2018) were analyzed. A total of 874 respondents were selected via total sampling based on inclusion and exclusion criteria. Data were collected in 2021, which included measures of knowledge, health check-ups, and HRQoL using the SF-36 questionnaire. Statistical analyses, including chi-square tests, t-tests, and multiple regression analyses, were conducted to examine the associations between MetS status and HRQoL. Results: Descriptive analysis revealed that 19% (171 participants) had worsened MetS status, while 80.4% (703 participants) showed improvement. Chi-Square analysis found that respondents with worsening MetS status were 1.6 times more likely to experience poor HRQoL in the physical dimension (95% CI = 1.1-2.3), but no significant effect was found for the mental dimension (PR = 1.1, 95% CI = 0.8-1.6). Multiple logistic regression analysis revealed that comorbidities interacted with worsening MetS status to significantly affect HRQoL in the physical dimension. The adjusted prevalence ratios (PR) were 27.5 (95% CI = 10.3-73.2) for those with comorbidities and 9.2 (95% CI = 5.7-15.0) for those without comorbidities, after controlling for age, mental health, BMI changes, routine health checks, and knowledge. Conclusion: Changes in MetS status towards worsening have a significant negative effect on HRQoL, particularly in the physical dimension. The presence of comorbidities in individuals with worsening MetS status greatly increases the risk of poor HRQoL. Healthcare professionals and nurses should consider the interaction between MetS and comorbidities in patient management. Nurses are encouraged to monitor HRQoL in patients with MetS, promote education on managing comorbidities, and collaborate across disciplines to enhance patient care and intervention programs aimed at improving HRQoL.
C1 [Indriyati, Titi] Univ Mohammad Husni Thamrin Jakarta, Fac Hlth, Jakarta, Indonesia.
   [Adisasmita, Asri C.; Nadjib, Mardiati; Hatma, Ratna Djuwita; Kosen, Soewarta] Univ Indonesia, Fac Publ Hlth, Depok, Indonesia.
   [Subekti, Imam] Cipto Mangunkusumo Natl Cent Gen Hosp, Jakarta, Indonesia.
   [Riyadina, Woro; Purnamasari, Telly] Natl Res & Innovat Agcy BRIN, Jakarta, Indonesia.
C3 University of Indonesia; National Research & Innovation Agency of
   Indonesia (BRIN)
RP Indriyati, T (corresponding author), Univ Mohammad Husni Thamrin Jakarta, Fac Hlth, Jakarta, Indonesia.
EM indriyati2901@gmail.com
RI Riyadina, Woro/IQW-6286-2023
FU Epidemiology Study Program, Faculty of Public Health, Universitas
   Indonesia
FX The authors would like to thank the Head of the Health Research and
   Development Agency of the Indonesian Ministry of Health, the Principal
   Investigator of the NCD Cohort Study in Bogor City, the enumerator team,
   health cadres in the study area, and all participants who voluntarily
   provided their information. They also greatly acknowledge the
   Epidemiology Study Program, Faculty of Public Health, Universitas
   Indonesia, and all leaders at Universitas Mohammad Husni Thamrin,
   Jakarta, for supporting this study.
CR Agustin M. J., 2022, Indonesian Health Journal, V1, P62, DOI [10.58344/ihj.v1i2.19, DOI 10.58344/IHJ.V1I2.19]
   Al Shehri HA, 2022, OPEN MED-WARSAW, V17, P341, DOI 10.1515/med-2021-0397
   Al-Qawasmeh RH, 2018, CURR RES NUTR FOOD S, V6, P594, DOI 10.12944/CRNFSJ.6.3.03
   Amiri P, 2018, INT J ENDOCRINOL MET, V16, DOI 10.5812/ijem.84745
   Amiri P, 2014, J DIABETES INVEST, V5, P687, DOI 10.1111/jdi.12222
   [Anonymous], 2022, What is Metabolic Syndrome?
   Asnani Monika Rani, 2017, Glob Pediatr Health, V4, p2333794X17739194, DOI 10.1177/2333794X17739194
   Barcelo MA, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0176665
   Chackrewarthy S, 2013, ISRN Endocrinol, V2013, P320176, DOI 10.1155/2013/320176
   Fauziyah N., 2019, Data analysis uses multiple logistic regression tests in the fields of public and clinical health, V1st
   Frempong-Ainguah F., 2014, Quetelet Journal, V2, P7, DOI [10.14428/rqj2014.02.02.01, DOI 10.14428/RQJ2014.02.02.01]
   Grundy SM, 2018, ENDOCRINOL SER, P71, DOI 10.1007/978-3-319-44433-8_3
   Herningtyas EH, 2019, BMC PUBLIC HEALTH, V19, DOI 10.1186/s12889-019-6711-7
   Indonesia Ministry of Health, 2012, Technical instructions: Integrated development post for non-communicable diseases (POSBINDU PTM)
   Indonesian Ministry of Health, 2016, PTM prevention and control of non-communicable diseases in Indonesia
   Indonesian Ministry of Health, 2018, Basic Health Research 2018 report (Riskesdas)
   Indonesian Ministry of Health, 2013, Riset kesehatan dasar
   Indonesian Ministry of Health, 2022, P2PTM Annual Report 2021
   Jafar N., 2018, Indian Journal of Public Health Research & Development, V9, P263
   Jia XX, 2018, DIABETOL METAB SYNDR, V10, DOI 10.1186/s13098-018-0328-3
   Karyani AK, 2019, INT J HUM RIGHTS HEA, V12, P28, DOI 10.1108/IJHRH-05-2018-0036
   Knox SA, 2009, QUAL LIFE RES, V18, P637, DOI 10.1007/s11136-009-9467-1
   Leventhal H, 2016, J BEHAV MED, V39, P935, DOI 10.1007/s10865-016-9782-2
   Lin YH, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-99767-y
   Makbul A. A., 2019, Guidelines for managing dyslipidemia in Indonesia 2019
   Megari K, 2013, HEALTH PSYCHOL RES, V1, P141, DOI [10.4082/hpr.2013.e27, 10.4081/hpr.2013.e27]
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Novitasari L., 2016, Jurnal Kedokteran dan Kesehatan Indonesia, V7, P80, DOI DOI 10.20885/JKKI.VOL7.ISS3.ART2
   Parikh Rakesh M, 2012, Indian J Endocrinol Metab, V16, P7, DOI 10.4103/2230-8210.91175
   Payot A, 2011, CURR PROB PEDIATR AD, V41, P91, DOI 10.1016/j.cppeds.2010.10.008
   Postolova A., 2014, Journal of Scientific Research and Reports, V3, P1088, DOI [10.9734/JSRR/2014/7748, DOI 10.9734/JSRR/2014/7748]
   Rampal S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046365
   RAND Health Care, 2020, RAND 36-Item Health Survey 1.0 Questionnaire items (SF-36)
   Rashvand F, 2021, ASIAN J SOC HEAL BEH, V4, P69, DOI 10.4103/shb.shb_72_20
   Regufe Virginia M G, 2020, Porto Biomed J, V5, pe101, DOI 10.1097/j.pbj.0000000000000101
   Riyadina W., 2019, Final report of the 2019 non- communicable disease risk factor cohort study
   Roohafza H, 2012, INT J ENDOCRINOL, V2012, DOI 10.1155/2012/380902
   Saboya PP, 2016, REV LAT-AM ENFERM, V24, DOI 10.1590/1518-8345.1573.2848
   Salim S, 2017, ACTA MED INDONES, V49, P10
   Shofany C., 2017, Nursing Care Open Access Journal, V4, DOI DOI 10.15406/NCOAJ.2017.04.00103
   Sigit FS, 2022, PREV MED REP, V27, DOI 10.1016/j.pmedr.2022.101806
   Sihombing M., 2015, Penelitian Gizi Dan Makanan, V38, P21, DOI [10.22435/pgm.v38i1.4418.21-30, DOI 10.22435/PGM.V38I1.4418.21-30]
   Sihombing M, 2015, MEDIA PENELIT PENGEM, V25, P219
   Sulistiowati E, 2016, UNIVERSA MED, V35, P46, DOI 10.1805/UnivMed.2016.v35.46-55
   Ware J. E., 1994, SF-36 physical and mental summary scales: A users manual
   WHO, 2024, Noncommunicable diseases
NR 46
TC 0
Z9 0
U1 0
U2 0
PU BELITUNG RAYA FOUNDATION
PI BELITUNG
PA RT 06 RW 02, URISAN JAYA, PADANG, BELITUNG TIMUR, MANGGAR, BANGKA,
   BELITUNG, INDONESIA
SN 2528-181X
EI 2477-4073
J9 BELITUNG NURS J
JI Belitung Nurs. J.
PD MAR-APR
PY 2025
VL 11
IS 2
BP 172
EP 185
DI 10.33546/bnj.3543
PG 14
WC Nursing
WE Emerging Sources Citation Index (ESCI)
SC Nursing
GA 1SE9P
UT WOS:001472403200001
PM 40256385
DA 2025-06-11
ER

PT J
AU Correll, CU
AF Correll, Christoph U.
TI Balancing efficacy and safety in treatment with antipsychotics
SO CNS SPECTRUMS
LA English
DT Review
ID CORONARY-HEART-DISEASE; CARDIOVASCULAR RISK-FACTORS; CATIE SCHIZOPHRENIA
   TRIAL; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; METABOLIC SYNDROME;
   ATYPICAL ANTIPSYCHOTICS; BIPOLAR-DISORDER; SCHIZOAFFECTIVE DISORDER;
   WEIGHT-GAIN
AB Balancing efficacy with tolerability and safety of prescribed treatments is critical to optimizing antipsychotic treatment outcomes in the mentally ill. Symptom control, symptom remission, and functional recovery are only realistic goals when treatments are both effective and well tolerated. The consideration of predictable differences in antipsychotic adverse-effect profiles is central to successful illness management. Minimizing adverse effects on alertness, motivation, cognition, sexual/reproductive functioning, and physical health enhances mental health outcomes, partly through improving treatment adherence. Neuroendocrine and metabolic side effects of antipsychotics for cardiovascular morbidity and mortality need to be addressed proactively and aggressively. In view of the widespread lack of primary care engagement and the adverse effects of psychotropic medications on cardiovascular health, psychiatric care providers should function as key facilitators of an integrated mental and physical health management approach. In addition to psychoeducation and healthy lifestyle counseling, clinicians can improve psychiatric and physical health by selecting medications carefully, routinely screening and monitoring for reversible cardiovascular risk factors, and playing an active role in the prevention and interdisciplinary management of cardiovascular risk factors and medical illness in the vulnerable mentally ill.
C1 Zucker Hillside Hosp Queens, Recognit & Prevent Program, New York, NY USA.
   Albert Einstein Coll Med, Bronx, NY 10467 USA.
C3 Northwell Health; Montefiore Medical Center; Albert Einstein College of
   Medicine; Yeshiva University
RP Correll, CU (corresponding author), Zucker Hillside Hosp Queens, Recognit & Prevent Program, New York, NY USA.
EM ccorrell@lii.edu
RI Correll, Christoph/D-3530-2011
CR Addington DEN, 2004, J CLIN PSYCHIAT, V65, P1624, DOI 10.4088/JCP.v65n1207
   Agid O, 2007, J CLIN PSYCHOPHARM, V27, P369, DOI 10.1097/JCP.0b013e3180d0a6d4
   ALLEBECK P, 1989, SCHIZOPHRENIA BULL, V15, P81, DOI 10.1093/schbul/15.1.81
   Allison DB, 1999, J CLIN PSYCHIAT, V60, P215, DOI 10.4088/JCP.v60n0402
   Amer Diabet Assoc, 2004, DIABETES CARE, V27, P596, DOI 10.2337/diacare.27.2.596
   Azorin JM, 2001, AM J PSYCHIAT, V158, P1305, DOI 10.1176/appi.ajp.158.8.1305
   Bassuk SS, 2005, J APPL PHYSIOL, V99, P1193, DOI 10.1152/japplphysiol.00160.2005
   Bergman RN, 2005, J CLIN PSYCHIAT, V66, P504, DOI 10.4088/JCP.v66n0414
   Birkenaes AB, 2007, J CLIN PSYCHIAT, V68, P917, DOI 10.4088/JCP.v68n0614
   Buckley PF, 2005, SCHIZOPHR RES, V79, P281, DOI 10.1016/j.schres.2005.04.010
   CARDENAS J, 2007, J AFFECT DISORD 0610
   Casey DE, 2003, PSYCHOPHARMACOLOGY, V166, P391, DOI 10.1007/s00213-002-1344-3
   Cassidy F, 1999, AM J PSYCHIAT, V156, P1417
   Chrzanowski WK, 2006, PSYCHOPHARMACOLOGY, V189, P259, DOI 10.1007/s00213-006-0564-3
   Clevenger CV, 2003, ENDOCR REV, V24, P1, DOI 10.1210/er.2001-0036
   Cohn T, 2004, CAN J PSYCHIAT, V49, P753, DOI 10.1177/070674370404901106
   Colton Craig W, 2006, Prev Chronic Dis, V3, pA42
   Conley RR, 2001, AM J PSYCHIAT, V158, P765, DOI 10.1176/appi.ajp.158.5.765
   Coombes RC, 2004, NEW ENGL J MED, V350, P1081, DOI 10.1056/NEJMoa040331
   Correll CU, 2007, SCHIZOPHR RES, V92, P103, DOI 10.1016/j.schres.2007.01.004
   Correll CU, 2006, J AM ACAD CHILD PSY, V45, P771, DOI 10.1097/01.chi.0000220851.94392.30
   Correll CU, 2006, J CLIN PSYCHIAT, V67, P575, DOI 10.4088/JCP.v67n0408
   Correll CU, 2006, J CLIN PSYCHIAT, V67, P160, DOI 10.4088/JCP.v67n0122
   Correll CU, 2004, AM J PSYCHIAT, V161, P414, DOI 10.1176/appi.ajp.161.3.414
   Correll CU, 2004, PSYCHOPHARMACOLOGY, V174, P477, DOI 10.1007/s00213-004-1949-9
   Critchley JA, 2003, JAMA-J AM MED ASSOC, V290, P86, DOI 10.1001/jama.290.1.86
   CUFFEL B, 2006, 58 I PSYCH SERV ANN
   Davidson S, 2001, AUST NZ J PSYCHIAT, V35, P196, DOI 10.1046/j.1440-1614.2001.00877.x
   Davis JM, 2003, ARCH GEN PSYCHIAT, V60, P553, DOI 10.1001/archpsyc.60.6.553
   De Hert M, 2006, Clin Pract Epidemiol Ment Health, V2, P14
   De Hert M, 2007, SCHIZOPHRENIA BULL, V33, P823, DOI 10.1093/schbul/sbl037
   De Hert M, 2006, J CLIN PSYCHIAT, V67, P1889, DOI 10.4088/JCP.v67n1208
   Dixon L, 1999, J NERV MENT DIS, V187, P496, DOI 10.1097/00005053-199908000-00006
   Druss BG, 2001, ARCH GEN PSYCHIAT, V58, P565, DOI 10.1001/archpsyc.58.6.565
   Eliassen AH, 2007, INT J CANCER, V120, P1536, DOI 10.1002/ijc.22482
   Essock SM, 2006, AM J PSYCHIAT, V163, P2090, DOI 10.1176/appi.ajp.163.12.2090
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   Faulkner G, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005148.pub2
   Frye RL, 2003, AM J MED, V115, P93, DOI 10.1016/j.amjmed.2003.09.015
   GARCIAPORTILLA MP, 2007, J AFFECT DISORD 0711
   Goff DC, 2005, SCHIZOPHR RES, V80, P45, DOI 10.1016/j.schres.2005.08.010
   Grunze H, 2004, ACTA PSYCHIAT SCAND, V110, P21
   Haddad PM, 2004, DRUGS, V64, P2291, DOI 10.2165/00003495-200464200-00003
   Heiskanen T, 2003, J CLIN PSYCHIAT, V64, P575, DOI 10.4088/JCP.v64n0513
   Henderson DC, 2005, AM J PSYCHIAT, V162, P954, DOI 10.1176/appi.ajp.162.5.954
   Hennekens CH, 1998, CIRCULATION, V97, P1095, DOI 10.1161/01.CIR.97.11.1095
   Hennekens CH, 2005, AM HEART J, V150, P1115, DOI 10.1016/j.ahj.2005.02.007
   Heres S, 2006, AM J PSYCHIAT, V163, P185, DOI 10.1176/appi.ajp.163.2.185
   Herrán A, 2000, SCHIZOPHR RES, V41, P373, DOI 10.1016/S0920-9964(99)00082-1
   Howard L, 2007, BRIT J PSYCHIAT, V190, P129, DOI 10.1192/bjp.bp.106.023671
   Jones PB, 2006, ARCH GEN PSYCHIAT, V63, P1079, DOI 10.1001/archpsyc.63.10.1079
   Kane J, 2007, SCHIZOPHR RES, V90, P147, DOI 10.1016/j.schres.2006.09.012
   Kane JM, 2007, CNS SPECTRUMS, V12, P21, DOI 10.1017/S1092852900026304
   Kato Martha M., 2004, Prim Care Companion J Clin Psychiatry, V6, P74
   Kemmler G, 2005, ARCH GEN PSYCHIAT, V62, P1305, DOI 10.1001/archpsyc.62.12.1305
   Kilbourne AM, 2004, BIPOLAR DISORD, V6, P368, DOI 10.1111/j.1399-5618.2004.00138.x
   Kilbourne AM, 2007, J AFFECT DISORDERS, V102, P145, DOI 10.1016/j.jad.2007.01.006
   Kinon BJ, 2005, J CLIN PSYCHOPHARM, V25, P255, DOI 10.1097/01.jcp.0000161501.65890.22
   Klein DJ, 2006, AM J PSYCHIAT, V163, P2072, DOI 10.1176/appi.ajp.163.12.2072
   Knowler WC, 2002, NEW ENGL J MED, V346, P393, DOI 10.1056/nejmoa012512
   Koro CE, 2002, ARCH GEN PSYCHIAT, V59, P1021, DOI 10.1001/archpsyc.59.11.1021
   Lambert Timothy J R, 2003, Med J Aust, V178, pS67
   Leucht S, 1999, SCHIZOPHR RES, V35, P51, DOI 10.1016/S0920-9964(98)00105-4
   Leucht S, 2003, AM J PSYCHIAT, V160, P1209, DOI 10.1176/appi.ajp.160.7.1209
   Li TY, 2006, CIRCULATION, V113, P499, DOI 10.1161/CIRCULATIONAHA.105.574087
   Lieberman JA, 2005, NEW ENGL J MED, V353, P1209, DOI 10.1056/NEJMoa051688
   MANSON JE, 1992, NEW ENGL J MED, V326, P1406, DOI 10.1056/NEJM199205213262107
   March JS, 2005, AM J PSYCHIAT, V162, P836, DOI 10.1176/appi.ajp.162.5.836
   Marder SR, 2004, AM J PSYCHIAT, V161, P1334, DOI 10.1176/appi.ajp.161.8.1334
   Marder SR, 2003, SCHIZOPHR RES, V61, P123, DOI 10.1016/S0920-9964(03)00050-1
   MARDER SR, 2007, BIOL PSYCHIAT    JUN
   McElroy SL, 2002, J CLIN PSYCHIAT, V63, P207, DOI 10.4088/JCP.v63n0306
   McEvoy JP, 2007, AM J PSYCHIAT, V164, P1050, DOI 10.1176/appi.ajp.164.7.1050
   McEvoy JP, 2005, SCHIZOPHR RES, V80, P19, DOI 10.1016/j.schres.2005.07.014
   McQuade RD, 2004, J CLIN PSYCHIAT, V65, P47
   Meltzer HY, 2003, ARCH GEN PSYCHIAT, V60, P82, DOI 10.1001/archpsyc.60.1.82
   Meyer J, 2005, INT REV PSYCHIATR, V17, P173, DOI 10.1080/09540260500071798
   Meyer JM, 2005, CLIN THER, V27, P1930, DOI 10.1016/j.clinthera.2005.12.005
   Nakonezny PA, 2007, J SEX MARITAL THER, V33, P203, DOI 10.1080/00926230701267829
   Nasrallah HA, 2006, SCHIZOPHR RES, V86, P15, DOI 10.1016/j.schres.2006.06.026
   Newcomer John W, 2004, J Clin Psychopharmacol, V24, pS1, DOI 10.1097/01.jcp.0000142281.85207.d5
   Newcomer JW, 2005, CNS DRUGS, V19, P1
   O'Keane V, 2005, J CLIN PSYCHOPHARM, V25, P26, DOI 10.1097/01.jcp.0000150223.31007.e0
   Perlis RH, 2006, J CLIN PSYCHIAT, V67, P509, DOI 10.4088/JCP.v67n0401
   RICHEDWARDS JW, 1995, NEW ENGL J MED, V332, P1758, DOI 10.1056/NEJM199506293322607
   Scherk H, 2007, ARCH GEN PSYCHIAT, V64, P442, DOI 10.1001/archpsyc.64.4.442
   Schooler N, 2005, AM J PSYCHIAT, V162, P947, DOI 10.1176/appi.ajp.162.5.947
   Serri O, 2006, CLIN ENDOCRINOL, V64, P366, DOI 10.1111/j.1365-2265.2006.02469.x
   Shim JC, 2007, AM J PSYCHIAT, V164, P1404, DOI 10.1176/appi.ajp.2007.06071075
   Simpson GM, 2004, AM J PSYCHIAT, V161, P1837, DOI 10.1176/appi.ajp.161.10.1837
   Straker D, 2005, AM J PSYCHIAT, V162, P1217, DOI 10.1176/appi.ajp.162.6.1217
   Stroup TS, 2007, AM J PSYCHIAT, V164, P415, DOI 10.1176/appi.ajp.164.3.415
   Stroup TS, 2006, AM J PSYCHIAT, V163, P611, DOI 10.1176/appi.ajp.163.4.611
   Suppes T, 2007, PSYCHOPHARMACOL BULL, V40, P22
   Szarfman A, 2006, PHARMACOTHERAPY, V26, P748, DOI 10.1592/phco.26.6.748
   Tarsy D, 2002, CNS DRUGS, V16, P23, DOI 10.2165/00023210-200216010-00003
   Üçok A, 2004, PSYCHIAT CLIN NEUROS, V58, P434, DOI 10.1111/j.1440-1819.2004.01279.x
   Vieta E, 2002, BIPOLAR DISORD, V4, P335, DOI 10.1034/j.1399-5618.2002.01204.x
   Weiden P J, 2001, J Psychiatr Pract, V7, P41, DOI 10.1097/00131746-200101000-00005
   Weiden PJ, 2003, J CLIN PSYCHIAT, V64, P580, DOI 10.4088/JCP.v64n0514
   WEIDEN PJ, 2007, NEUROPSYCHOPHARMACOL
   Weissman EM, 2006, J CLIN PSYCHIAT, V67, P1323, DOI 10.4088/JCP.v67n0901
   WOEMER MG, 2003, AM J PSYCHIAT, V160, P1514
   Woods SW, 2005, ARCH GEN PSYCHIAT, V62, P961, DOI 10.1001/archpsyc.62.9.961
   Yatham LN, 2004, J CLIN PSYCHOPHARM, V24, P599, DOI 10.1097/01.jcp.0000144887.66319.2f
   Yumru M, 2007, J AFFECT DISORDERS, V98, P247, DOI 10.1016/j.jad.2006.08.009
   Zipursky RB, 2005, BRIT J PSYCHIAT, V187, P537, DOI 10.1192/bjp.187.6.537
NR 107
TC 67
Z9 69
U1 0
U2 19
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1092-8529
EI 2165-6509
J9 CNS SPECTRUMS
JI CNS Spectr.
PD OCT
PY 2007
VL 12
IS 10
SU 17
BP 12
EP +
DI 10.1017/S1092852900026298
PG 10
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 229SZ
UT WOS:000250825900003
PM 17934385
DA 2025-06-11
ER

PT J
AU Emik-Ozdemir, B
   Tunc-Ata, M
   Ozdemir, Y
   Kilic-Erkek, O
   Senol, H
   Kucukatay, V
   Bor-Kucukatay, M
AF Emik-Ozdemir, Busra
   Tunc-Ata, Melek
   Ozdemir, Yasin
   Kilic-Erkek, Ozgen
   Senol, Hande
   Kucukatay, Vural
   Bor-Kucukatay, Melek
TI The effects of swimming exercise and detraining on hemorheological
   parameters and oxidative stress in rats with metabolic syndrome
SO NUTRITION CLINIQUE ET METABOLISME
LA English
DT Article
DE Monosodium glutamate (MSG); Exercise training; Detraining; Antioxidant
   status; Whole blood viscosity (WBV)
ID REGULAR EXERCISE; BLOOD-VISCOSITY; OBESE; ASSOCIATION; INTENSITY;
   GLUCOSE; DEFENSE; PLASMA
AB Background. - Moderate-intensity aerobic exercise training with high frequency is recommended in metabolic syndrome (MetS). We aimed to investigate the effects of swimming and subsequent detraining on hemorheology and oxidative stress in MetS.Material and methods. - A total of 80 rats were used. MetS was induced by a 4 mg/g monosodium glutamate (MSG) injection to rats on days 0-10, every other day. Swimming exercise training was applied 30 minutes, 3 days/week, with a 5% body weight load, for 18 weeks. Detraining was applied for 8 weeks. Erythrocyte deformability was measured with an ektacytometer, whole blood viscosity (WBV) by a cone-plate viscometer, total oxidant-antioxidant capacity (TOS-TAS) were measured by commercial kits.Results. - Exercise resulted in an increment of HDL in rats with MetS, which was not reversed by detraining. Swimming decreased HOMA-IR score in MetS. Detraining caused an increase in WBV in healthy rats. The exercise applied resulted in an increase in TAS in both healthy and MetS rats.Conclusion. - We suggest that swimming may be beneficial in MetS and may contribute positively to the prevention of the development of possible complications by increasing TAS. Since some of the gains of exercise training are reversed by detraining, lifetime exercise training may be recommended.& COPY; 2023 Societe francophone nutrition clinique et metabolisme (SFNCM). Published by Elsevier Masson SAS. All rights reserved.
C1 [Emik-Ozdemir, Busra] Bigad State Hosp, Phys Therapy Unit, TR-10440 Bigadic, Balikesir, Turkiye.
   [Tunc-Ata, Melek; Kilic-Erkek, Ozgen; Kucukatay, Vural; Bor-Kucukatay, Melek] Pamukkale Univ, Fac Med, Dept Physiol, TR-20070 Kinikli, Denizli, Turkiye.
   [Ozdemir, Yasin] Tercih Common Hlth & Safety Unit, TR-10100 Altieylul, Balikesir, Turkiye.
   [Senol, Hande] Pamukkale Univ, Fac Med, Dept Biostat, TR-20070 Kinikli, Denizli, Turkiye.
C3 Bigadic State Hospital; Pamukkale University; Pamukkale University
RP Bor-Kucukatay, M (corresponding author), Pamukkale Univ, Fac Med, Dept Physiol, TR-20070 Kinikli, Denizli, Turkiye.
EM mbor@pau.edu.tr
RI Kucukatay, Vural/ABI-6427-2020; Kilic-Erkek, Ozgen/AAA-1237-2022
FU PAU Scientific Research Projects Coordination Unit [2018SABE033]
FX This work was supported by the PAU Scientific Research Projects
   Coordination Unit (Project no: 2018SABE033) .
CR Abou Ehnagd M., 2016, Int. J. Phys. Educ. Sports Health, V3, P22
   Anderson EJ, 2009, J CLIN INVEST, V119, P573, DOI 10.1172/JCI37048
   Balbo SL, 2007, ENDOCRINE, V31, P142, DOI 10.1007/s12020-007-0021-z
   Bogdanis GC, 2013, FOOD CHEM TOXICOL, V61, P171, DOI 10.1016/j.fct.2013.05.046
   Borck PC, 2020, CLIN EXP PHARMACOL P, V47, P286, DOI 10.1111/1440-1681.13197
   Bruna JF, 2013, CLIN HEMORHEOL MICRO, V55, P15, DOI 10.3233/CH-131686
   Cekirdekci EI, 2020, REV PORT CARDIOL, V39, P17, DOI 10.1016/j.repc.2019.04.008
   Churilla JR, 2008, AM J LIFESTYLE MED, V2, P118, DOI 10.1177/1559827607311981
   Colak E, 2005, ANN MED, V37, P613, DOI 10.1080/07853890500330193
   Davidson MH, 2011, J CLIN LIPIDOL, V5, P338, DOI 10.1016/j.jacl.2011.07.005
   Demirtas CY, 2018, BRATISL MED J, V119, P36, DOI 10.4149/BLL_2018_008
   Dolnikoff M, 2001, INT J OBESITY, V25, P426, DOI 10.1038/sj.ijo.0801517
   Dumortier M, 2002, CLIN HEMORHEOL MICRO, V26, P219
   Espitia-Bautista E, 2017, METABOLISM, V72, P83, DOI 10.1016/j.metabol.2017.04.006
   Farinha JB, 2015, SPORTS MED-OPEN, V1, DOI 10.1186/s40798-015-0011-2
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gyawali P, 2015, REDOX REP, V20, P139, DOI 10.1179/1351000214Y.0000000120
   Gyawali P, 2014, MICROVASC RES, V95, P31, DOI 10.1016/j.mvr.2014.06.013
   HARDEMAN MR, 1994, CLIN HEMORHEOL, V14, P605
   Harma M, 2003, SWISS MED WKLY, V133, P563
   Bautista RJH, 2019, BIOMED PHARMACOTHER, V111, P503, DOI 10.1016/j.biopha.2018.12.108
   Imbernon M, 2013, GASTROENTEROLOGY, V144, P636, DOI 10.1053/j.gastro.2012.10.051
   Inoguchi T, 2000, DIABETES, V49, P1939, DOI 10.2337/diabetes.49.11.1939
   Irace C, 2009, NUTR METAB CARDIOVAS, V19, P476, DOI 10.1016/j.numecd.2008.11.005
   Kilic-Erkek O, 2014, BIORHEOLOGY, V51, P355, DOI 10.3233/BIR-14030
   Kiran TR, 2004, COMP BIOCHEM PHYS B, V137, P187, DOI 10.1016/j.cbpc.2003.11.002
   Mendoza-Núñez VM, 2018, CLIN INTERV AGING, V13, P523, DOI 10.2147/CIA.S157584
   Minato Satomi, 2017, J Clin Med Res, V9, P332, DOI 10.14740/jocmr2885w
   Miranda RA, 2014, CELL PHYSIOL BIOCHEM, V33, P1075, DOI 10.1159/000358677
   Myers J, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071652
   OLNEY JW, 1969, SCIENCE, V164, P719, DOI 10.1126/science.164.3880.719
   Ostman C, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-017-0590-y
   Otani H, 2011, ANTIOXID REDOX SIGN, V15, P1911, DOI 10.1089/ars.2010.3739
   Ribeiro RA, 2013, MOL BIOL REP, V40, P4521, DOI 10.1007/s11033-013-2546-y
   Samson SL, 2014, ENDOCRIN METAB CLIN, V43, P1, DOI 10.1016/j.ecl.2013.09.009
   Scomparin DX, 2011, ENDOCR RES, V36, P83, DOI 10.3109/07435800.2010.534750
   Stoltz JF, 1985, ACTA MEDICA PORT, V6, P4
   Svidnicki PV, 2015, ARCH ENDOCRIN METAB, V59, P210, DOI 10.1590/2359-3997000000039
   Swamy AHMV, 2013, INDIAN J PHARM SCI, V75, P657
   Unver F, 2019, CLIN HEMORHEOL MICRO, V71, P463, DOI 10.3233/CH-180402
   Vayá A, 2011, CLIN HEMORHEOL MICRO, V49, P493, DOI 10.3233/CH-2011-1499
   Vezzoli A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0087506
   Wang YT, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0515-5
   Way KL, 2016, DIABETES METAB J, V40, P253
   Wiewiora M, 2014, CLIN HEMORHEOL MICRO, V56, P101, DOI 10.3233/CH-2012-1642
NR 45
TC 0
Z9 0
U1 0
U2 5
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0985-0562
EI 1768-3092
J9 NUTR CLIN METAB
JI Nutr. Clin. Metab.
PD MAY
PY 2023
VL 37
IS 2
BP 94
EP 100
DI 10.1016/j.nupar.2023.01.003
EA MAY 2023
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA M0FG0
UT WOS:001026940300001
DA 2025-06-11
ER

PT J
AU Pin, NT
AF Pin, Ng Tze
TI Cognitive Health of Older Persons in Longitudinal Ageing Cohort Studies
SO SAINS MALAYSIANA
LA English
DT Article
DE Aging; cognitive function; dementia; older adult; risk factor
ID ALZHEIMERS-DISEASE; BLOOD-PRESSURE; LEISURE ACTIVITIES; RISK-FACTORS;
   METABOLIC SYNDROME; TEA CONSUMPTION; MARITAL-STATUS; LATER LIFE;
   DEMENTIA; DECLINE
AB Dementia poses a major global burden of care to society and health systems in ageing populations. The majority (over 60%) of persons with dementia in the world are found in Asia and developing countries with rapid rates of population ageing. Improving and maintaining the cognitive health of older persons is vital to national strategies for dementia prevention. Increasing numbers of population-based ageing cohort studies in the past decade have provided a better understanding of the factors that contribute to cognitive function and decline in old age. The roles of major demographic, psychosocial, lifestyle, behavioral and cardiovascular risk factors contributing to cognitive health were discussed using examples from the Singapore Longitudinal Ageing Studies. They include socio-demographic factors, particularly education and marital status, leisure time activity such as physical activity, social engagement and mental activities, psychological factors such as depression, cardiovascular and metabolic risk factors: obesity, diabetes, hypertension and dyslipidemia, and the metabolic syndrome, under-nutrition, low albumin, low hemoglobin, nutritional factors such as blood folate, B12 and homocysteine, omega-3 poly-unsaturated fatty acids, tea drinking and curcumin-rich turmeric in curry meals. These factors are found to be associated variously with cognitive functions (memory and learning, language, visuospatial, attention and information processing speed), rates of cognitive impairment and cognitive decline, or increased risk of developing MCI and progression to dementia.
C1 [Pin, Ng Tze] Natl Univ Singapore, Yong Yoo Lin Sch Med, Res Programme, Dept Psychol Med & Gerontol, 21 Lower Kent Ridge Rd, Singapore 119077, Singapore.
C3 National University of Singapore
RP Pin, NT (corresponding author), Natl Univ Singapore, Yong Yoo Lin Sch Med, Res Programme, Dept Psychol Med & Gerontol, 21 Lower Kent Ridge Rd, Singapore 119077, Singapore.
EM pcmngtp@nus.edu.sg
FU Biomedical Research Council, Agency for Science, Technology and Research
   [03/1/21/17/214]; National Medical Research Council [08/1/21/19/567];
   National Medical Research Council (NMRC/CG/NUHCS); Geylang East Home for
   the Aged; Presbyterian Community Services; Thye Hua Kwan Moral Society
   (Moral Neighbourhood Links); Yuhua Neighbourhood Link; Henderson Senior
   Citizens' Home; NTUC Eldercare Co-op Ltd; Thong Kheng Seniors Activity
   Centre (Queenstown Centre); Redhill Moral Seniors Activity Centre
FX The study was supported by research grant funding from the Biomedical
   Research Council, Agency for Science, Technology and Research
   (03/1/21/17/214) and National Medical Research Council (08/1/21/19/567
   and NMRC/CG/NUHCS/2010). The authors would like to thank the following
   voluntary welfare organizations for their support of the Singapore
   Longitudinal Ageing Studies: Geylang East Home for the Aged,
   Presbyterian Community Services, Thye Hua Kwan Moral Society (Moral
   Neighbourhood Links), Yuhua Neighbourhood Link, Henderson Senior
   Citizens' Home, NTUC Eldercare Co-op Ltd, Thong Kheng Seniors Activity
   Centre (Queenstown Centre) and Redhill Moral Seniors Activity Centre.
CR [Anonymous], 2014, DEMENTIA RISK REDUCT
   Anstey KJ, 2011, OBES REV, V12, pe426, DOI 10.1111/j.1467-789X.2010.00825.x
   Bassuk SS, 1998, ARCH GEN PSYCHIAT, V55, P1073, DOI 10.1001/archpsyc.55.12.1073
   Beydoun MA, 2008, OBES REV, V9, P204, DOI 10.1111/j.1467-789X.2008.00473.x
   Boyle PA, 2010, ARCH GEN PSYCHIAT, V67, P304, DOI 10.1001/archgenpsychiatry.2009.208
   Brookmeyer R, 2007, ALZHEIMERS DEMENT, V3, P186, DOI 10.1016/j.jalz.2007.04.381
   Buchman AS, 2005, NEUROLOGY, V65, P892, DOI 10.1212/01.wnl.0000176061.33817.90
   Feng L, 2012, J NUTR HEALTH AGING, V16, P754, DOI 10.1007/s12603-012-0077-1
   Feng L, 2010, J NUTR HEALTH AGING, V14, P433
   Feng L, 2014, DEMENT GER COGN D EX, V4, P375, DOI 10.1159/000358584
   Feng L, 2013, AM J GERIAT PSYCHIAT, V21, P164, DOI 10.1016/j.jagp.2012.10.017
   Feng L, 2006, AM J CLIN NUTR, V84, P1506, DOI 10.1093/ajcn/84.6.1506
   Fratiglioni L, 2004, LANCET NEUROL, V3, P343, DOI 10.1016/S1474-4422(04)00767-7
   Gao Q, 2011, J NUTR HEALTH AGING, V15, P32, DOI 10.1007/s12603-011-0010-z
   Geerlings MI, 2000, BRIT J PSYCHIAT, V176, P568, DOI 10.1192/bjp.176.6.568
   Håkansson K, 2009, BMJ-BRIT MED J, V339, DOI 10.1136/bmj.b2462
   Hamid TA, 2010, DEMENT GERIATR COGN, V30, P533, DOI 10.1159/000321672
   Ho RCM, 2008, AM J GERIAT PSYCHIAT, V16, P519, DOI 10.1097/JGP.0b013e31816b7841
   International A.s.D., 2015, WORLD ALZHEIMER REPO, DOI DOI 10.1111/J.0963-7214.2004.00293.X
   Johansson L, 2010, BRAIN, V133, P2217, DOI 10.1093/brain/awq116
   Karp A, 2006, DEMENT GERIATR COGN, V21, P65, DOI 10.1159/000089919
   Kivipelto M, 2001, BMJ-BRIT MED J, V322, P1447, DOI 10.1136/bmj.322.7300.1447
   Launer LJ, 2000, NEUROBIOL AGING, V21, P49, DOI 10.1016/S0197-4580(00)00096-8
   Launer LJ, 2005, NEUROBIOL AGING, V26, P335, DOI 10.1016/j.neurobiolaging.2004.03.016
   Luchsinger JA, 2007, ARCH NEUROL-CHICAGO, V64, P392, DOI 10.1001/archneur.64.3.392
   Muller M, 2014, PEDIATRICS, V134, P761, DOI 10.1542/peds.2014-1108
   Ng TP, 2008, AGE AGEING, V37, P423, DOI 10.1093/ageing/afn102
   Ng TP, 2016, JAMA NEUROL, V73, P456, DOI 10.1001/jamaneurol.2015.4899
   Ng TP, 2014, J ALZHEIMERS DIS, V41, P61, DOI 10.3233/JAD-131901
   Ng TP, 2010, DEMENT GERIATR COGN, V29, P131, DOI 10.1159/000275668
   Ng TP, 2009, J AM GERIATR SOC, V57, P1058, DOI 10.1111/j.1532-5415.2009.02262.x
   Ng TP, 2008, AM J CLIN NUTR, V88, P224, DOI 10.1093/ajcn/88.1.224
   Ng TP, 2006, AM J EPIDEMIOL, V164, P898, DOI 10.1093/aje/kwj267
   Ng TP, 2009, J AM GERIATR SOC, V57, P101, DOI 10.1111/j.1532-5415.2008.02086.x
   Ninomiya T, 2011, HYPERTENSION, V58, P22, DOI 10.1161/HYPERTENSIONAHA.110.163055
   Niti M, 2008, INT PSYCHOGERIATR, V20, P237, DOI 10.1017/S1041610207006655
   O'Leary F, 2012, BRIT J NUTR, V108, P1948, DOI 10.1017/S0007114512004175
   Posner HB, 2002, NEUROLOGY, V58, P1175, DOI 10.1212/WNL.58.8.1175
   Qiu CX, 2007, CURR OPIN PSYCHIATR, V20, P380, DOI 10.1097/YCO.0b013e32816ebc7b
   Qiu CX, 2010, J ALZHEIMERS DIS, V20, P689, DOI 10.3233/JAD-2010-091663
   Reitz C, 2004, ARCH NEUROL-CHICAGO, V61, P705, DOI 10.1001/archneur.61.5.705
   Singh B, 2014, J ALZHEIMERS DIS, V39, P271, DOI 10.3233/JAD-130830
   Skoog I, 2003, LANCET NEUROL, V2, P334, DOI 10.1016/S1474-4422(03)00405-8
   Skoog I, 1996, LANCET, V347, P1141, DOI 10.1016/S0140-6736(96)90608-X
   Solfrizzi V, 2011, NEUROBIOL AGING, V32, P1932, DOI 10.1016/j.neurobiolaging.2009.12.012
   Song J, 2012, J NUTR HEALTH AGING, V16, P31, DOI 10.1007/s12603-011-0139-9
   SPECK CE, 1995, EPIDEMIOLOGY, V6, P366, DOI 10.1097/00001648-199507000-00006
   Stern Y, 2002, J INT NEUROPSYCH SOC, V8, P448, DOI 10.1017/S1355617702813248
   Sydenham E, 2012, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD005379.pub3, 10.1590/S1516-31802012000600013]
   Tang MX, 2001, NEUROLOGY, V56, P49, DOI 10.1212/WNL.56.1.49
   Wang HX, 2002, AM J EPIDEMIOL, V155, P1081, DOI 10.1093/aje/155.12.1081
NR 51
TC 2
Z9 2
U1 0
U2 24
PU UNIV KEBANGSAAN MALAYSIA
PI SELANGOR
PA FACULTY SCIENCE & TECHNOLOGY, BANGI, SELANGOR, 43600, MALAYSIA
SN 0126-6039
J9 SAINS MALAYS
JI Sains Malays.
PD SEP
PY 2016
VL 45
IS 9
BP 1351
EP 1355
PG 5
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EA4PF
UT WOS:000386594400009
DA 2025-06-11
ER

PT J
AU Wüst, S
   Entringer, S
   Federenko, IS
   Schlotz, W
   Hellhammer, DH
AF Wüst, S
   Entringer, S
   Federenko, IS
   Schlotz, W
   Hellhammer, DH
TI Birth weight is associated with salivary cortisol responses to
   psychosocial. stress in adult life
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE hypothalamus-pituitary-adrenal axis; prenatal stress; birth weight;
   length of gestation; TSST
ID PITUITARY-ADRENAL AXIS; FETAL-ORIGINS HYPOTHESIS; PRENATAL STRESS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; GESTATIONAL-AGE; HEART-DISEASE;
   HPA AXIS; PREGNANCY; SECRETION
AB Fetal programming of the hypothalamus-pituitary-adrenal (HPA) axis was proposed as one mechanism underlying the link between prenatal stress, adverse birth outcomes (particularly tow birth weight) and an enhanced vulnerability for several diseases later in life. In recent studies, birth weight was significantly related to basal cortisol levels as well as to cortisol responses to pharmacological stimulation.
   In order to investigate the association between cortisol responses to psychological challenge, birth weight and length of gestation, 106 young healthy mates were exposed to the 'Trier Social Stress Test'. Salivary cortisol responses to the stress exposure were significantly and inversely related to the subjects' birth weight, white the analysis of the impact of gestational age yielded inconsistent results.
   This finding is consistent with the concept of fetal programming of the HPA axis and provides the first preliminary evidence for an association between birth weight and adrenocortical responses to psychosocial stress. As the investigated subjects were twins, possible implications of this sample characteristic for the present findings are discussed. (c) 2005 Elsevier Ltd. All rights reserved.
C1 Univ Trier, Dept Psychobiol, D-54290 Trier, Germany.
C3 Universitat Trier
RP Univ Trier, Dept Psychobiol, Johanniterufer 15, D-54290 Trier, Germany.
EM wuest@uni-trier.de
RI Schlotz, Wolff/AAI-9549-2020; Hellhammer, Dirk/F-1888-2013; Entringer,
   Sonja/ABB-9405-2020; Yim, Ilona/D-4331-2011
OI Entringer, Sonja/0000-0002-9926-7076; Wust, Stefan/0000-0002-2315-8949;
   Schlotz, Wolff/0000-0003-2356-7766
CR Bagiella E, 2000, PSYCHOPHYSIOLOGY, V37, P13, DOI 10.1017/S0048577200980648
   Barbazanges A, 1996, J NEUROSCI, V16, P3943
   Barker DJP, 1999, ANN INTERN MED, V130, P322, DOI 10.7326/0003-4819-130-4-199902160-00019
   Barker DJP, 2002, TRENDS ENDOCRIN MET, V13, P364, DOI 10.1016/S1043-2760(02)00689-6
   BARKER DJP, 1995, BRIT MED J, V311, P1203, DOI 10.1136/bmj.311.7014.1203
   BARKER DJP, 1992, J HYPERTENS, V10, pS39
   Bartels M, 2003, PSYCHONEUROENDOCRINO, V28, P121, DOI 10.1016/S0306-4530(02)00003-3
   Bo S, 2001, EXP CLIN ENDOCR DIAB, V109, P135, DOI 10.1055/s-2001-14835
   CHRISTENSEN K, 1995, BRIT MED J, V310, P432, DOI 10.1136/bmj.310.6977.432
   CRATTY MS, 1995, BRAIN RES, V675, P297, DOI 10.1016/0006-8993(95)00087-7
   De Kloet ER, 1998, ENDOCR REV, V19, P269, DOI 10.1210/er.19.3.269
   DRESSENDORFER RA, 1992, J STEROID BIOCHEM, V43, P683, DOI 10.1016/0960-0760(92)90294-S
   Federenko IS, 2004, J CLIN ENDOCR METAB, V89, P6244, DOI 10.1210/jc.2004-0981
   Federenko IS, 2004, CNS SPECTRUMS, V9, P198, DOI 10.1017/S1092852900008993
   Glynn LM, 2001, AM J OBSTET GYNECOL, V184, P637, DOI 10.1067/mob.2001.111066
   HEDEGAARD M, 1993, BMJ-BRIT MED J, V307, P234, DOI 10.1136/bmj.307.6898.234
   Herman JP, 2003, FRONT NEUROENDOCRIN, V24, P151, DOI 10.1016/j.yfrne.2003.07.001
   HRUBEC Z, 1981, HUM GENET, V59, P39, DOI 10.1007/BF00278852
   Huizink AC, 2004, PSYCHOL BULL, V130, P115, DOI 10.1037/0033-2909.130.1.115
   Kajantie E, 2004, CLIN ENDOCRINOL, V60, P201, DOI 10.1046/j.1365-2265.2003.01965.x
   Kajantie E, 2003, EUR J ENDOCRINOL, V149, P569, DOI 10.1530/eje.0.1490569
   Kajantie E, 2002, CLIN ENDOCRINOL, V57, P635, DOI 10.1046/j.1365-2265.2002.01659.x
   Kirschbaum C, 1999, PSYCHOSOM MED, V61, P154, DOI 10.1097/00006842-199903000-00006
   KIRSCHBAUM C, 1994, CLIN INVESTIGATOR, V72, P804
   KIRSCHBAUM C, 1993, NEUROPSYCHOBIOLOGY, V28, P76, DOI 10.1159/000119004
   KIRSCHBAUM C, 1992, J CLIN ENDOCR METAB, V75, P1526, DOI 10.1210/jc.75.6.1526
   Kramer MS, 2003, J NUTR, V133, p1592S, DOI 10.1093/jn/133.5.1592S
   Levitt NS, 2000, J CLIN ENDOCR METAB, V85, P4611, DOI 10.1210/jc.85.12.4611
   LINKOWSKI P, 1993, AM J PHYSIOL, V264, pE173, DOI 10.1152/ajpendo.1993.264.2.E173
   Matthews SG, 2002, TRENDS ENDOCRIN MET, V13, P373, DOI 10.1016/S1043-2760(02)00690-2
   Oswald LM, 2004, PSYCHONEUROENDOCRINO, V29, P371, DOI 10.1016/S0306-4530(03)00048-9
   PAARLBERG KM, 1995, J PSYCHOSOM RES, V39, P563, DOI 10.1016/0022-3999(95)00018-6
   Paarlberg KM, 1999, BRIT J OBSTET GYNAEC, V106, P834, DOI 10.1111/j.1471-0528.1999.tb08406.x
   Phillips D I, 2001, Twin Res, V4, P327, DOI 10.1375/1369052012669
   Phillips DIW, 1998, J CLIN ENDOCR METAB, V83, P757, DOI 10.1210/jc.83.3.757
   Phillips DIW, 2000, HYPERTENSION, V35, P1301, DOI 10.1161/01.HYP.35.6.1301
   Raison CL, 2003, AM J PSYCHIAT, V160, P1554, DOI 10.1176/appi.ajp.160.9.1554
   Reynolds RM, 2001, J CLIN ENDOCR METAB, V86, P245, DOI 10.1210/jc.86.1.245
   Schmidt-Reinwald A, 1999, LIFE SCI, V64, P1653, DOI 10.1016/S0024-3205(99)00103-4
   Schommer NC, 2003, PSYCHOSOM MED, V65, P450, DOI 10.1097/01.PSY.0000035721.12441.17
   VAGERO D, 1994, LANCET, V343, P260, DOI 10.1016/S0140-6736(94)91112-6
   Wadhwa P D, 2001, Prog Brain Res, V133, P131
   Walker BR, 2002, CLIN ENDOCRINOL, V57, P351, DOI 10.1046/j.1365-2265.2002.01606.x
   Ward AMV, 2004, J CLIN ENDOCR METAB, V89, P1227, DOI 10.1210/jc.2003-030978
   Weinstock M, 1997, NEUROSCI BIOBEHAV R, V21, P1, DOI 10.1016/S0149-7634(96)00014-0
   Weinstock M, 2001, PROG NEUROBIOL, V65, P427, DOI 10.1016/S0301-0082(01)00018-1
   Welberg LAM, 2001, J NEUROENDOCRINOL, V13, P113, DOI 10.1046/j.1365-2826.2001.00601.x
   Wüst S, 2000, PSYCHONEUROENDOCRINO, V25, P707, DOI 10.1016/S0306-4530(00)00021-4
   Wüst S, 2005, PSYCHONEUROENDOCRINO, V30, P591, DOI 10.1016/j.psyneuen.2005.01.008
   Wüst S, 2004, J CLIN ENDOCR METAB, V89, P565, DOI 10.1210/jc.2003-031148
NR 50
TC 163
Z9 173
U1 0
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JUL
PY 2005
VL 30
IS 6
BP 591
EP 598
DI 10.1016/j.psyneuen.2005.01.008
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 917XN
UT WOS:000228502700009
PM 15808929
DA 2025-06-11
ER

PT J
AU Kazukauskiene, N
   Podlipskyte, A
   Varoneckas, G
   Mickuviene, N
AF Kazukauskiene, Nijole
   Podlipskyte, Aurelija
   Varoneckas, Giedrius
   Mickuviene, Narseta
TI Health-related quality of life and insulin resistance over a 10-year
   follow-up
SO SCIENTIFIC REPORTS
LA English
DT Article
ID METABOLIC SYNDROME; MENTAL-HEALTH; HYPERINSULINEMIA; STATEMENT
AB The aim of the study was to investigate the association between insulin resistance (IR) and health-related quality of life (HRQoL) among citizens of Palanga in a 10-year follow-up. A randomized epidemiological study was performed with 835 subjects. The following data were examined using questionnaires: sociodemographic characteristics, behavioural factors, HRQoL and self-perceived health. Fasting blood samples were drawn from all participants, and biochemical tests were performed for glucose and insulin. IR was evaluated by the homeostasis model assessment of IR (HOMA-IR). In subjects with IR, after adjusting for various factors, logistic regression analysis showed that within 10 years, there was a significantly higher chance of deteriorating HRQoL in the areas of physical functioning (odds ratio [OR] = 1.15, p < 0.001), emotional role limitations (OR = 1.07, p = 0.034), social functioning (OR = 1.26, p = 0.004), pain (OR = 1.09, p = 0.005) and general health perception (OR = 1.07, p = 0.022). People with IR have a worse HRQoL, and as they age, they are significantly more likely to have a deterioration in their HRQoL than people without IR in the areas of physical functioning, emotional role limitations, social functioning, pain and general health perception.
C1 [Kazukauskiene, Nijole; Podlipskyte, Aurelija; Varoneckas, Giedrius; Mickuviene, Narseta] Lithuanian Univ Hlth Sci, Neurosci Inst, Lab Behav Med, Vyduno Al 4, LT-00135 Palanga, Lithuania.
C3 Lithuanian University of Health Sciences
RP Kazukauskiene, N (corresponding author), Lithuanian Univ Hlth Sci, Neurosci Inst, Lab Behav Med, Vyduno Al 4, LT-00135 Palanga, Lithuania.
EM nijole.kazukauskiene@lsmuni.lt
OI Podlipskyte, Aurelija/0000-0003-1412-6168; Varoneckas,
   Giedrius/0000-0001-8073-4335
FU Research Council of Lithuania [S-SEN-20-13]
FX This research is funded by a grant (No. S-SEN-20-13) from the Research
   Council of Lithuania.
CR Agewall S, 2008, CORONARY ARTERY DIS, V19, P289, DOI 10.1097/MCA.0b013e3282fc618f
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Andruskiene J., 2014, PUBLIC HEALTH, V81
   Beale EG, 2013, J INVEST MED, V61, P11, DOI 10.2310/JIM.0b013e3182746f95
   Cadeddu C, 2016, CARDIOL THER, V5, P63, DOI 10.1007/s40119-016-0057-3
   da Silva AA, 2020, CAN J CARDIOL, V36, P671, DOI 10.1016/j.cjca.2020.02.066
   Matheus ASD, 2013, INT J HYPERTENS, V2013, DOI 10.1155/2013/653789
   Deihim T, 2015, HEALTH QUAL LIFE OUT, V13, DOI 10.1186/s12955-015-0391-5
   Eddy D, 2009, DIABETES CARE, V32, P361, DOI 10.2337/dc08-0854
   Erceg P, 2013, CLIN INTERV AGING, V8, P1539, DOI 10.2147/CIA.S53305
   Ezzati A, 2019, ALZ DIS ASSOC DIS, V33, P240, DOI 10.1097/WAD.0000000000000324
   Freeman A.M., 2021, INSULIN RESISTANCE
   Gerber M, 2009, SCAND J PUBLIC HEALT, V37, P801, DOI 10.1177/1403494809350522
   Grabauskas V., 2011, SUAUGUSIU LIETUVOS Z
   Han TS, 2013, EUR J ENDOCRINOL, V168, P887, DOI 10.1530/EJE-13-0128
   Kim KH, 2018, SCI REP-UK, V8, DOI [10.1038/s41598-018-23254-0, 10.1038/s41598-018-21168-5]
   Llaneza P, 2009, FERTIL STERIL, V91, P1370, DOI 10.1016/j.fertnstert.2008.04.031
   Ma LN, 2015, CLIN CHIM ACTA, V444, P18, DOI 10.1016/j.cca.2015.01.027
   Mirr M, 2021, J ENDOCRINOL INVEST, V44, P2831, DOI 10.1007/s40618-021-01608-2
   Noh JW, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-40090-y
   Ohrnberger J, 2017, SOC SCI MED, V195, P42, DOI 10.1016/j.socscimed.2017.11.008
   Onyango AN, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/4321714
   Perry RJ, 2014, NATURE, V510, P84, DOI 10.1038/nature13478
   Pickering TG, 2005, CIRCULATION, V111, P697, DOI 10.1161/01.CIR.0000154900.76284.F6
   Saboya PP, 2016, REV LAT-AM ENFERM, V24, DOI 10.1590/1518-8345.1573.2848
   Sayer AA, 2005, DIABETES CARE, V28, P2541, DOI 10.2337/diacare.28.10.2541
   Schlotz W, 2007, QUAL LIFE RES, V16, P429, DOI 10.1007/s11136-006-9129-5
   Sesti G, 2006, BEST PRACT RES CL EN, V20, P665, DOI 10.1016/j.beem.2006.09.007
   Shanik MH, 2008, DIABETES CARE, V31, pS262, DOI 10.2337/dc08-s264
   Szatkowski L, 2015, NICOTINE TOB RES, V17, P356, DOI 10.1093/ntr/ntu173
   Tziallas D, 2012, EUR J CARDIOVASC NUR, V11, P297, DOI 10.1016/j.ejcnurse.2011.02.004
   Wallace TM, 2004, DIABETES CARE, V27, P1487, DOI 10.2337/diacare.27.6.1487
   WARE JE, 1992, MED CARE, V30, P473, DOI 10.1097/00005650-199206000-00002
   Wild S, 2004, DIABETES CARE, V27, P1047, DOI 10.2337/diacare.27.5.1047
   World Health Organization Regional Office for Europe, 1998, WELL BEING MEAS PRIM
NR 35
TC 8
Z9 9
U1 0
U2 8
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 21
PY 2021
VL 11
IS 1
AR 24294
DI 10.1038/s41598-021-03791-x
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA XR9VH
UT WOS:000732567600081
PM 34934126
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hetrick, S
   Alvarez-Jiménez, M
   Parker, A
   Hughes, F
   Willet, M
   Morley, K
   Fraser, R
   McGorry, P
   Thompson, A
AF Hetrick, Sarah
   Alvarez-Jimenez, Mario
   Parker, Alexandra
   Hughes, Frank
   Willet, Michaela
   Morley, Katherine
   Fraser, Richard
   McGorry, Patrick
   Thompson, Andrew
TI Promoting physical health in youth mental health services: ensuring
   routine monitoring of weight and metabolic indices in a first episode
   psychosis clinic
SO AUSTRALASIAN PSYCHIATRY
LA English
DT Article
DE adverse effects; evidence based practice; first episode psychosis;
   knowledge transfer; metabolic syndrome
ID RISK-ASSESSMENT; ANTIPSYCHOTICS; IMPLEMENTATION; DISORDERS; CARE
AB Objective: Clinicians are increasingly being asked to implement guideline recommendations into their practice, but are given little practical guidance on this complex task. In this paper we outline a promising theory-driven approach we took to implementing guideline recommendations about routine monitoring of weight gain and metabolic disturbance in our first-episode psychosis clinic. While there is significant psychological and physical morbidity associated with weight gain and metabolic disturbance, routine monitoring was not being undertaken according to guideline recommendations. We examined the factors that make it difficult to undertake routine monitoring by interviewing psychiatrists. This barrier analysis allowed us to develop and introduce feasible and acceptable strategies to address these barriers, increasing the likelihood that routine monitoring would take place.
   Conclusion: This paper advocates for undertaking an analysis of the barriers clinicians face to undertaking evidence-based practice in order to develop more sophisticated approaches to address areas where clinical practice and evidence are divergent. Such an approach is more likely to ensure that measures to improve practice are successful, are meaningful for the clinicians involved, and become imbedded in the clinical practice of the service.
C1 [Hetrick, Sarah; Parker, Alexandra; Willet, Michaela] Univ Melbourne, Ctr Youth Mental Hlth, Orygen Youth Hlth Res Centre, Ctr Excellence, Melbourne, Vic, Australia.
   [Hetrick, Sarah; Parker, Alexandra; Willet, Michaela; McGorry, Patrick] Natl Youth Mental Hlth Fdn, Melbourne, Vic, Australia.
   [Hughes, Frank] EPPIC Clin Orygen Youth Hlth, Melbourne, Vic, Australia.
   [Morley, Katherine] Univ Melbourne, Ctr Youth Mental Hlth, Orygen Youth Hlth Res Ctr, Appl Genet Unit, Melbourne, Vic, Australia.
   [Morley, Katherine] Univ Melbourne, Sch Populat Hlth, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia.
   [Fraser, Richard] Univ Melbourne, Ctr Youth Mental Hlth, Youth Hlth Res Ctr, Melbourne, Vic, Australia.
   [McGorry, Patrick; Thompson, Andrew] Orygen Youth Hlth, Melbourne, Vic, Australia.
C3 University of Melbourne; Orygen, The National Centre of Excellence in
   Youth Mental Health; Orygen, The National Centre of Excellence in Youth
   Mental Health; University of Melbourne; University of Melbourne; Orygen,
   The National Centre of Excellence in Youth Mental Health; University of
   Melbourne; Orygen, The National Centre of Excellence in Youth Mental
   Health
RP Hetrick, S (corresponding author), Univ Melbourne, Ctr Youth Mental Hlth, Orygen Youth Hlth Res Centre, Ctr Excellence, Locked Bag 10, Parkville, Vic 3052, Australia.
EM shetrick@unimelb.edu.au
RI Parker, Alexandra/AER-0997-2022; Hetrick, Sarah/AAT-1277-2020; McGorry,
   Patrick/O-4115-2019; Thompson, Andrew/F-3153-2012; Alvarez-Jimenez,
   Mario/G-4691-2013; Morley, Katherine/A-2986-2011
OI McGorry, Patrick/0000-0002-3789-6168; Parker,
   Alexandra/0000-0002-2398-6306; Thompson, Andrew/0000-0002-0567-6013;
   Alvarez-Jimenez, Mario/0000-0002-3535-9086; Morley,
   Katherine/0000-0002-2725-5535
CR Alvarez-Jiménez M, 2008, CNS DRUGS, V22, P547, DOI 10.2165/00023210-200822070-00002
   [Anonymous], MENTAL HLTH AUSTR CO
   Bick P, 2007, AUSTRALAS PSYCHIATRY, V15, P465, DOI 10.1080/10398560701689186
   Braun V., 2006, Qualitative Research in Psychology, V3, P77, DOI [10.1191/1478088706oa, DOI 10.1191/1478088706OA, DOI 10.1191/1478088706QP063OA]
   Dunbar L, 2010, AUSTRALAS PSYCHIATRY, V18, P322, DOI 10.3109/10398561003692571
   Dunbar L, 2010, AUSTRALAS PSYCHIATRY, V18, P318, DOI 10.3109/10398561003692563
   Grimshaw JM, 2004, HEALTH TECHNOL ASSES, V8, P1, DOI 10.3310/hta8060
   Grol R, 2001, MED CARE, V39, pII46
   Grol R, 2008, CAN J PSYCHIAT, V53, P275, DOI 10.1177/070674370805300501
   Hennekens CH, 2007, J CLIN PSYCHIAT, V68, P4
   Jamtvedt G, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD000259.pub2
   Killackey E, 2008, AUST NZ J PSYCHIAT, V42, P439, DOI 10.1080/00048670802050652
   Lambert TJR, 2004, MED J AUSTRALIA, V181, P544, DOI 10.5694/j.1326-5377.2004.tb06443.x
   Marder SR, 2004, AM J PSYCHIAT, V161, P1334, DOI 10.1176/appi.ajp.161.8.1334
   McGorry PD, 1996, SCHIZOPHRENIA BULL, V22, P305, DOI 10.1093/schbul/22.2.305
   MCGORRY PD, 2006, PSYCH B, V2
   Michie S, 2005, QUAL SAF HEALTH CARE, V14, P26, DOI 10.1136/qshc.2004.011155
   Minichiello V., 1995, IN DEPTH INTERVIEWIN, V2nd
   Nasrallah Henry A, 2004, J Clin Psychopharmacol, V24, pS7, DOI 10.1097/01.jcp.0000142282.62336.e9
   Newcomer JW, 2007, J CLIN PSYCHIAT, V68, P8
   Newcomer JW, 2005, CNS DRUGS, V19, P1
   *NHMRC, 2000, PUT EVID PRACT IMPL
   Rege S, 2008, AUST NZ J PSYCHIAT, V42, pA108
   Tschoner A, 2007, INT J CLIN PRACT, V61, P1356, DOI 10.1111/j.1742-1241.2007.01416.x
   Walter G, 2008, AUSTRALAS PSYCHIATRY, V16, P253, DOI 10.1080/10398560801958549
   Waterreus AJ, 2009, MED J AUSTRALIA, V190, P185, DOI 10.5694/j.1326-5377.2009.tb02344.x
NR 26
TC 29
Z9 30
U1 0
U2 12
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1039-8562
EI 1440-1665
J9 AUSTRALAS PSYCHIATRY
JI Australas. Psychiatry
PD OCT
PY 2010
VL 18
IS 5
BP 451
EP 455
DI 10.3109/10398561003731189
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 675HD
UT WOS:000283817400013
PM 20863186
DA 2025-06-11
ER

PT J
AU Karupaiah, T
   Chuah, KA
   Chinna, K
   Matsuoka, R
   Masuda, Y
   Sundram, K
   Sugano, M
AF Karupaiah, Tilakavati
   Chuah, Khun-Aik
   Chinna, Karuthan
   Matsuoka, Ryosuke
   Masuda, Yasunobu
   Sundram, Kalyana
   Sugano, Michihiro
TI Comparing effects of soybean oil- and palm olein-based mayonnaise
   consumption on the plasma lipid and lipoprotein profiles in human
   subjects: a double-blind randomized controlled trial with cross-over
   design
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Mayonnaise; Fatty acids; Cardiometabolic risk; Lipids; Lipoprotein
   particles
ID CORONARY-HEART-DISEASE; FATTY-ACIDS; ENZYMATIC DETERMINATION;
   CARDIOVASCULAR-DISEASE; DIETARY FATS; CHOLESTEROL; SERUM; RISK; MEN;
   INFLAMMATION
AB Background: Mayonnaise is used widely in contemporary human diet with widespread use as a salad dressing or spread on breads. Vegetable oils used in its formulation may be a rich source of omega-6 PUFAs and the higher-PUFA content of mayonnaise may be beneficial in mediating a hypocholesterolemic effect. This study, therefore, evaluated the functionality of mayonnaise on cardiometabolic risk within a regular human consumption scenario.
   Methods: Subjects underwent a randomized double-blind crossover trial, consuming diets supplemented with 20 g/day of either soybean oil-based mayonnaise (SB-mayo) or palm olein-based mayonnaise (PO-mayo) for 4 weeks each with a 2-week wash-out period. The magnitude of changes for metabolic outcomes between dietary treatments was compared with PO-mayo serving as the control. The data was analyzed by ANCOVA using the GLM model. Analysis was adjusted for weight changes.
   Results: Treatments resulted in significant reductions in TC (diff = -0.25 mmol/L; P = 0.001), LDL-C (diff = -0. 17 mmol/L; P = 0.016) and HDL-C (diff = -0.12 mmol/L; P < 0.001) in SB-mayo compared to PO-mayo without affecting LDL-C: HDL-C ratio (P > 0.05). Lipoprotein particle change was significant with large LDL particles increasing after PO-mayo (diff = +63.2 nmol/L; P = 0.007) compared to SB-mayo but small LDL particles remained unaffected. Plasma glucose, apolipoproteins and oxidative stress markers remained unchanged.
   Conclusions: Daily use with 20 g of linoleic acid-rich SB-mayo elicited reductions in TC and LDL-C concentrations without significantly changing LDL-C: HDL-C ratio or small LDL particle distributions compared to the PO-mayo diet.
C1 [Karupaiah, Tilakavati] Natl Univ Malaysia, Sch Healthcare Sci, Dietet Program, Fac Hlth Sci, Kuala Lumpur, Malaysia.
   [Chuah, Khun-Aik] Natl Univ Malaysia, Sch Healthcare Sci, Nutr Program, Fac Hlth Sci, Kuala Lumpur, Malaysia.
   [Chinna, Karuthan] Univ Malaya, Dept Social & Prevent Med, Julius Ctr, Fac Med, Kuala Lumpur, Malaysia.
   [Matsuoka, Ryosuke; Masuda, Yasunobu] Kewpie Corp, R&D Div, 2-5-7 Sengawa Cho, Chofu, Tokyo, Japan.
   [Sundram, Kalyana] Malaysian Palm Oil Council, Kelana Jaya, Selangor, Malaysia.
   [Sugano, Michihiro] Kyushu Univ, Kyushu, Japan.
   [Sugano, Michihiro] Prefectual Univ Kumamoto, Kyushu, Japan.
C3 Universiti Kebangsaan Malaysia; Universiti Kebangsaan Malaysia;
   Universiti Malaya; Kyushu University
RP Karupaiah, T (corresponding author), Natl Univ Malaysia, Sch Healthcare Sci, Dietet Program, Fac Hlth Sci, Kuala Lumpur, Malaysia.
EM tilly_karu@yahoo.co.uk
RI Matsuoka, Ryosuke/LOS-1392-2024; chinna, karuthan/E-4495-2014;
   Karupaiah, Tilakavati/C-9868-2013
OI Matsuoka, Ryosuke/0000-0002-4511-6272; KARUPAIAH,
   TILAKAVATI/0000-0001-5808-8074
FU Kewpie Corporation, Japan [NN-188-2010]
FX This study was supported by a grant (NN-188-2010) received from Kewpie
   Corporation, Japan.
CR Akter S, 2013, NUTR METAB, V10, DOI 10.1186/1743-7075-10-30
   ALLAIN CC, 1974, CLIN CHEM, V20, P470
   Amini M, 2010, NUTRITION, V26, P986, DOI 10.1016/j.nut.2010.03.006
   [Anonymous], 1968, LANCET, V2, P693
   [Anonymous], 2015, DIET GUID AM
   Baer DJ, 2004, AM J CLIN NUTR, V79, P969
   Baum SJ, 2012, J CLIN LIPIDOL, V6, P216, DOI 10.1016/j.jacl.2012.04.077
   Berneis KK, 2002, J LIPID RES, V43, P1363, DOI 10.1194/jlr.R200004-JLR200
   CHOUDHURY N, 1995, AM J CLIN NUTR, V61, P1043, DOI 10.1093/ajcn/61.5.1043
   Cromwell William C, 2004, Curr Atheroscler Rep, V6, P381, DOI 10.1007/s11883-004-0050-5
   Cusack LK, 2013, ADV NUTR, V4, P633, DOI 10.3945/an.113.004507
   Danesh J, NEW ENG J MED
   DataBank F, 2005, NUTR PRON AN SOFTW
   Donovan SM, 2014, AM J CLIN NUTR, V99, p1209S, DOI 10.3945/ajcn.113.073429
   Eckel RH, 2014, J AM COLL CARDIOL, V63, P2960, DOI 10.1016/j.jacc.2013.11.003
   Esposito K, 2006, EUR HEART J, V27, P15, DOI 10.1093/eurheartj/ehi605
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Fritsche KL, 2015, ADV NUTR, V6, p293S, DOI 10.3945/an.114.006940
   Hansson GK, 2005, NEW ENGL J MED, V352, P1685, DOI 10.1056/NEJMra043430
   Harika RK, 2013, ANN NUTR METAB, V63, P229, DOI 10.1159/000355437
   Herron KL, 2004, METABOLISM, V53, P823, DOI 10.1016/j.metabol.2003.12.030
   Indahl UG, 1999, CHEMOMETR INTELL LAB, V49, P19, DOI 10.1016/S0169-7439(99)00023-4
   Karupaiah T., 2005, HEALTHFUL LIPIDS, P171
   Karupaiah T, 2013, NUTR J, V12, DOI 10.1186/1475-2891-12-122
   Karupaiah T, 2011, J AM COLL NUTR, V30, P511, DOI 10.1080/07315724.2011.10719997
   Knopp RH, 1997, J AM COLL NUTR, V16, P551
   Kris-Eiherton PM, 2015, ADV NUTR, V6, p326S, DOI 10.3945/an.114.006981
   Ma J, 1997, AM J CLIN NUTR, V65, P551, DOI 10.1093/ajcn/65.2.551
   Ma Z, 2013, FOOD BIOPROCESS TECH, V6, P648, DOI 10.1007/s11947-012-1000-9
   MATTSON FH, 1985, J LIPID RES, V26, P194
   Micha R, 2014, BMJ-BRIT MED J, V348, DOI 10.1136/bmj.g2272
   MIETTINEN M, 1983, INT J EPIDEMIOL, V12, P17, DOI 10.1093/ije/12.1.17
   MIETTINEN TA, 1985, JAMA-J AM MED ASSOC, V254, P2097, DOI 10.1001/jama.254.15.2097
   Mozaffarian D, 2011, CIRCULATION, V123, P2870, DOI 10.1161/CIRCULATIONAHA.110.968735
   NAGELE U, 1984, J CLIN CHEM CLIN BIO, V22, P165
   NEWKIRK DR, 1978, J AM OIL CHEM SOC, V55, pA548, DOI 10.1007/BF02667261
   NG TKW, 1992, J AM COLL NUTR, V11, P383
   Otvos James D, 2002, Clin Lab, V48, P171
   Rett BS, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-36
   Saito S, 2006, NUTRITION, V22, P174, DOI 10.1016/j.nut.2005.05.013
   Scicchitano P, 2014, J FUNCT FOODS, V6, P11, DOI 10.1016/j.jff.2013.12.006
   SHIMIZU S, 1979, BIOCHEM BIOPH RES CO, V91, P108, DOI 10.1016/0006-291X(79)90589-8
   Shin JY, 2013, AM J CLIN NUTR, V98, P146, DOI 10.3945/ajcn.112.051318
   Sundram K, 2007, NUTR METAB, V4, DOI 10.1186/1743-7075-4-3
   Trinder P., 1969, Journal of Clinical Pathology, V22, P158, DOI 10.1136/jcp.22.2.158
   Walldius G, 2004, J INTERN MED, V255, P188, DOI 10.1046/j.1365-2796.2003.01276.x
   Wang DD, 2016, JAMA INTERN MED, V176, P1134, DOI 10.1001/jamainternmed.2016.2417
   WARNICK GR, 1982, CLIN CHEM, V28, P1379
   WATTS GF, 1994, AM J CARDIOL, V73, P328, DOI 10.1016/0002-9149(94)90003-5
   Yagi K, 1998, Methods Mol Biol, V108, P101
   YOUNG SG, 1990, CIRCULATION, V82, P1574, DOI 10.1161/01.CIR.82.5.1574
NR 51
TC 27
Z9 29
U1 0
U2 34
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD AUG 17
PY 2016
VL 15
AR 131
DI 10.1186/s12944-016-0301-9
PG 11
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA DT7RS
UT WOS:000381684900002
PM 27535127
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Prasad, M
   Goswami, S
   Kurkure, PA
AF Prasad, Maya
   Goswami, Savita
   Kurkure, Purna A.
TI The Care of Childhood Cancer Survivors in India: Challenges and
   Solutions
SO INDIAN JOURNAL OF MEDICAL AND PAEDIATRIC ONCOLOGY
LA English
DT Article
DE childhood cancer survivors; low- and middle-income countries;
   survivorship care
ID OUTCOMES; CHILDREN; BURDEN; RISK
AB Purpose We describe the challenges faced and lessons learnt over three decades of a childhood cancer survivorship program in India.Methods We provide a descriptive analysis of the challenges and barriers faced in running this program, our strategies in management, and detail the stages of development of holistic support system.Results The profile of late effects in our cohort of survivors is notable for the high prevalence of psychosocial issues and metabolic syndrome. Major difficulties faced were transitioning of patients to survivorship care and attrition to follow-up, which were overcome to an extent by ensuring constant communication/rapport-building, updated databases, and peer support groups. Collaborations with nonprofit organizations and other donors have enabled financial, psychosocial, educational, and vocational rehabilitation.Conclusions It is feasible to establish and sustain a survivorship program in a large-volume center in low- and medium-income country. Understanding the unique spectrum of late effects and establishing a holistic support system go a long way in ensuring the long-term physical and mental health and psychosocial concerns of childhood cancer survivors. Decentralization, development of a strong national networks, capacity building, and incorporation of sustainable technology should be priorities in survivorship care.
C1 [Prasad, Maya] Tata Mem Hosp, Div Paediat Oncol, Mumbai, Maharashtra, India.
   [Prasad, Maya; Goswami, Savita] Homi Bhabha Natl Inst HBNI, Mumbai, Maharashtra, India.
   [Goswami, Savita] Tata Mem Hosp, Dept Psychooncol, Mumbai, Maharashtra, India.
   [Kurkure, Purna A.] Narayana Hlth, SRCC Childrens Hosp, Dept Pediat Oncol & Bone Marrow Transplantat, Mumbai, Maharashtra, India.
   [Prasad, Maya] Tata Mem Hosp, Div Paediat Oncol, Mumbai 400012, Maharashtra, India.
C3 Tata Memorial Centre (TMC); Tata Memorial Hospital; Homi Bhabha National
   Institute; Tata Memorial Centre (TMC); Tata Memorial Hospital; Tata
   Memorial Centre (TMC); Tata Memorial Hospital
RP Prasad, M (corresponding author), Tata Mem Hosp, Div Paediat Oncol, Mumbai 400012, Maharashtra, India.
EM maya.prasad@gmail.com
CR Agarwal A, 2022, SUPPORT CARE CANCER, V30, P5075, DOI 10.1007/s00520-022-06910-0
   [Anonymous], Children's Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers: Health Links- Diet and Physical Activity
   Armstrong GT, 2014, J CLIN ONCOL, V32, P1218, DOI 10.1200/JCO.2013.51.1055
   Arora Puneet Rana, 2016, J Hum Reprod Sci, V9, P90, DOI 10.4103/0974-1208.183508
   Arora R., 2018, J GLOB ONCOL, V4, p74s
   Arora RS, 2020, PEDIATR BLOOD CANCER, V67, DOI 10.1002/pbc.28556
   Bakhshi, 2016, PEDIATR HEMAT ONCOL, V1, P13, DOI [10.1016/j.phoj.2016.04.005, DOI 10.1016/J.PHOJ.2016.04.005]
   Bhakta N, 2017, LANCET, V390, P2569, DOI 10.1016/S0140-6736(17)31610-0
   Chaturvedi SK, 2014, FRONT PSYCHOL, V5, DOI 10.3389/fpsyg.2014.01332
   Cheung YT, 2021, JCO GLOB ONCOL, V7, P261, DOI 10.1200/GO.20.00534
   Goda JS, 2020, NEURO-ONCOLOGY, V22, P1677, DOI 10.1093/neuonc/noaa076
   Gupta T, 2012, INT J RADIAT ONCOL, V83, P1534, DOI 10.1016/j.ijrobp.2011.10.037
   Henderson TO, 2015, J CLIN ONCOL, V33, P3849, DOI 10.1200/JCO.2015.63.7900
   Howard SC, 2017, PEDIATR BLOOD CANCER, V64, DOI 10.1002/pbc.26879
   Hudson MM, 2013, JAMA-J AM MED ASSOC, V309, P2371, DOI 10.1001/jama.2013.6296
   IGHG, INT LATE EFFECTS CHI
   Jalali R, 2010, INT J RADIAT ONCOL, V77, P974, DOI 10.1016/j.ijrobp.2009.06.025
   Jatia S, 2016, PEDIATR BLOOD CANCER, V63, pS89
   Jatia S, 2019, PEDIATR BLOOD CANCER, V66, DOI 10.1002/pbc.27716
   Kagramanov D, 2021, CANCER MED-US, V10, P5078, DOI 10.1002/cam4.4058
   Kurkure P., 2003, Indian Journal of Pediatrics, V70, P825, DOI 10.1007/BF02723807
   Kurkure P A., J CLIN ONCOL, V36, P46
   Kurkure PA, 2003, MED PEDIATR ONCOL, V41, P588, DOI 10.1002/mpo.10323
   Kurkure P, 2015, REPROD BIOL ENDOCRIN, V13, DOI 10.1186/s12958-015-0121-1
   Nipp RD, 2017, J CLIN ONCOL, V35, P3474, DOI 10.1200/JCO.2016.71.7066
   Phad P, 2016, PEDIATR BLOOD CANCER, V63, pS232
   Prasad M, 2015, INDIAN J CANCER, V52, P219, DOI 10.4103/0019-509X.175814
   Prasad M., 2020, NEURO-ONCOLOGY, V22
   Prasad M, 2022, JCO GLOB ONCOL, V8, DOI 10.1200/GO.22.00044
   Prasad M, 2022, SUPPORT CARE CANCER, V30, P3303, DOI 10.1007/s00520-021-06788-4
   Prasad M, 2021, PEDIATR BLOOD CANCER, V68, DOI 10.1002/pbc.29248
   Prasad M, 2020, PEDIATR BLOOD CANCER, V67, DOI 10.1002/pbc.28362
   Rathore V, 2020, INDIAN J MED PAEDIAT, V41, P707, DOI 10.4103/ijmpo.ijmpo_6_20
   Rawat-Pawar E, 2011, PEDIATR BLOOD CANCER, V57, P759
   Seth R., 2017, PEDIAT HEMATOLOGY ON, V2, pS5
   van den Oever SR, 2022, J CANCER SURVIV, V16, P1390, DOI 10.1007/s11764-021-01120-9
   worldbank, World Bank national accounts data, and OECD National Accounts data files. GDP (current US$)-Nigeria
NR 37
TC 2
Z9 2
U1 0
U2 3
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0971-5851
EI 0975-2129
J9 INDIAN J MED PAEDIAT
JI Indian J. Med. Paediatr. Oncol.
PD APR
PY 2024
VL 45
IS 02
BP 167
EP 172
DI 10.1055/s-0043-1761262
EA APR 2023
PG 6
WC Oncology
WE Emerging Sources Citation Index (ESCI)
SC Oncology
GA OZ0M1
UT WOS:000974128200008
OA gold
DA 2025-06-11
ER

PT J
AU Mitchell, AJ
   Lawrence, D
AF Mitchell, Alex J.
   Lawrence, David
TI Revascularisation and mortality rates following acute coronary syndromes
   in people with severe mental illness: comparative meta-analysis
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Review
ID INVASIVE CARDIAC PROCEDURES; ACUTE MYOCARDIAL-INFARCTION; CATIE
   SCHIZOPHRENIA TRIAL; INDUCED WEIGHT-GAIN; HEALTH-CARE-SYSTEM;
   QUALITY-OF-CARE; HEART-DISEASE; METABOLIC SYNDROME; EXCESS MORTALITY;
   RELATIVE RISK
AB Background
   High levels of comorbid physical illness and excess mortality rates have been previously documented in people with severe mental illness, but outcomes following myocardial infarction and other acute coronary syndromes are less clear.
   Aims
   To examine inequalities in the provision of invasive coronary procedures (revascularisation, angiography, angioplasty and bypass grafting) and subsequent mortality in people with mental illness and in those with schizophrenia, compared with those without mental ill health.
   Method
   Systematic search and random effects meta-analysis were used according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies of mental health and cardiovascular procedures following cardiac events were eligible but we required a minimum of three independent studies to warrant pooling by procedure type. We searched Medline/PubMed and EMBASE abstract databases and Science Direct, Ingenta Select, Springer Link and Online Wiley Library full text databases.
   Results
   We identified 22 analyses of possible inequalities in coronary procedures in those with defined mental disorder, of which 10 also reported results in schizophrenia or related psychosis. All studies following acute coronary syndrome originated in the USA. The total sample size was 825754 individuals. Those with mental disorders received 0.86 (relative risk, RR: 95% CI 0.80-0.92, P<0.0001) of comparable procedures with significantly lower receipt of coronary artery bypass graft (CABG; RR=0.85, 95% CI 0.72-1.00), cardiac catheterisation (RR = 0.85, 95% CI 0.76-0.95) and percutaneous transluminal coronary angioplasty or percutaneous coronary intervention (PTCA/PCI; RR=0.87, 95% CI 0.72-1.05). People with a diagnosis of schizophrenia received only 0.53 (95% CI 0.44-0.64, P<0.0001) of the usual procedure rate with significantly lower receipt of CABG (RR=0.69, 95% CI 0.55-0.85) and PTCA/PCI (RR=0.50, 95% CI 0.34-0.75). We identified 6 related studies examining mortality following cardiac events: for those with mental illness there was a 1.11 relative risk of mortality up to 1 year (95% CI 1.00-1.24, P=0.05) but there was insufficient evidence to examine mortality rates in schizophrenia alone.
   Conclusions
   Following cardiac events, individuals with mental illness experience a 14% lower rate of invasive coronary interventions (47% in the case of schizophrenia) and they have an 11% increased mortality rate. Further work is required to explore whether these factors are causally linked and whether improvements in medical care might improve survival in those with mental ill health.
C1 [Mitchell, Alex J.] Leicestershire Partnership Trust, Dept Liaison Psychiat, Leicester, Leics, England.
   [Mitchell, Alex J.] Leicester Royal Infirm, Dept Canc Studies & Mol Med, Leicester, Leics, England.
   [Lawrence, David] Univ Western Australia, Telethon Inst Child Hlth Res, Ctr Child Hlth Resaerch, Perth, WA 6009, Australia.
C3 University of Leicester; University of Western Australia; The Kids
   Research Institute Australia
RP Mitchell, AJ (corresponding author), Leicester Gen Hosp, Dept Liaison Psychiat, Gwendolen Rd, Leicester LE5 4PW, Leics, England.
EM Alex.mitchell@leicspart.nhs.uk
RI Mitchell, Alex/A-3090-2009; Mitchell, Alex/P-5671-2015; Lawrence,
   David/C-8292-2009
OI Mitchell, Alex/0000-0001-6014-598X; Lawrence, David/0000-0003-4700-1425
CR Abrams TE, 2009, CIRC-CARDIOVASC QUAL, V2, P213, DOI 10.1161/CIRCOUTCOMES.108.829143
   Al-Mandhari AS, 2004, FAM PRACT, V21, P519, DOI 10.1093/fampra/cmh508
   Allison DB, 1999, J CLIN PSYCHIAT, V60, P215, DOI 10.4088/JCP.v60n0402
   Alpert JS, 2000, J AM COLL CARDIOL, V36, P959, DOI 10.1016/S0735-1097(00)00804-4
   Alter DA, 1999, NEW ENGL J MED, V341, P1359, DOI 10.1056/NEJM199910283411806
   Alvarez-Jiménez M, 2006, J CLIN PSYCHIAT, V67, P1253, DOI 10.4088/JCP.v67n0812
   Amer Diabet Assoc, 2004, DIABETES CARE, V27, P596, DOI 10.2337/diacare.27.2.596
   Anderson JL, 2007, CIRCULATION, V116, pE148, DOI 10.1161/CIRCULATIONAHA.107.181940
   [Anonymous], 1996, GLOBAL BURDEN DIS IN
   [Anonymous], SCHIZ COR INT TREATM
   Bär KJ, 2007, SCHIZOPHR RES, V95, P115, DOI 10.1016/j.schres.2007.05.034
   BEGG CB, 1994, BIOMETRICS, V50, P1088, DOI 10.2307/2533446
   Bernardo M, 2006, SCHIZOPHR RES, V81, P176
   Blecker S, 2010, GEN HOSP PSYCHIAT, V32, P255, DOI 10.1016/j.genhosppsych.2010.02.002
   Brown S, 2000, BRIT J PSYCHIAT, V177, P212, DOI 10.1192/bjp.177.3.212
   Brown S, 1997, BRIT J PSYCHIAT, V171, P502, DOI 10.1192/bjp.171.6.502
   Buckley PF, 2005, SCHIZOPHR RES, V79, P281, DOI 10.1016/j.schres.2005.04.010
   Casey DE, 2004, J CLIN PSYCHIAT, V65, P4
   Citrome Leslie, 2005, J Psychopharmacol, V19, P102, DOI 10.1177/0269881105059505
   Cohn TA, 2006, CAN J PSYCHIAT, V51, P492, DOI 10.1177/070674370605100804
   Copeland LA, 2009, BMC HEALTH SERV RES, V9, DOI 10.1186/1472-6963-9-127
   Crone Diane, 2008, Issues Ment Health Nurs, V29, P1088, DOI 10.1080/01612840802319837
   Curkendall SM, 2004, J CLIN PSYCHIAT, V65, P715
   Daumit GL, 2005, J NERV MENT DIS, V193, P641, DOI 10.1097/01.nmd.0000180737.85895.60
   De Hert M, 2009, EUR PSYCHIAT, V24, P412, DOI 10.1016/j.eurpsy.2009.01.005
   De Hert M, 2006, INT CLIN PSYCHOPHARM, V21, pS11, DOI 10.1097/01.yic.0000201496.23259.85
   de Leon J, 2005, SCHIZOPHR RES, V76, P135, DOI 10.1016/j.schres.2005.02.010
   Desai MM, 2002, AM J PSYCHIAT, V159, P1584, DOI 10.1176/appi.ajp.159.9.1584
   Dombrovski A, 2004, CURR OPIN PSYCHIATR, V17, P523, DOI 10.1097/00001504-200411000-00018
   Druss BG, 2000, JAMA-J AM MED ASSOC, V283, P506, DOI 10.1001/jama.283.4.506
   Druss BG, 2001, ARCH GEN PSYCHIAT, V58, P565, DOI 10.1001/archpsyc.58.6.565
   Elming Hanne, 2002, Card Electrophysiol Rev, V6, P289, DOI 10.1023/A:1016345412555
   FALLOW S, 1995, INT J GERIATR PSYCH, V10, P74
   FARMER S, 1987, HOSP COMMUNITY PSYCH, V38, P745
   Filik R, 2006, ACTA PSYCHIAT SCAND, V113, P298, DOI 10.1111/j.1600-0447.2006.00768.x
   Fleischhacker WW, 2008, J CLIN PSYCHIAT, V69, P514, DOI 10.4088/JCP.v69n0401
   Ganguli R, 2007, J CLIN PSYCHIAT, V68, P19, DOI 10.4088/JCP.0607e14
   Goff DC, 2005, SCHIZOPHR RES, V80, P45, DOI 10.1016/j.schres.2005.08.010
   Grundy SM, 1999, CIRCULATION, V100, P1481, DOI 10.1161/01.CIR.100.13.1481
   Haupt DW, 2009, AM J PSYCHIAT, V166, P345, DOI 10.1176/appi.ajp.2008.08030383
   Heilä H, 2005, PSYCHOL MED, V35, P725, DOI 10.1017/S0033291704004118
   Heiskanen T, 2003, J CLIN PSYCHIAT, V64, P575, DOI 10.4088/JCP.v64n0513
   Hennekens CH, 2005, AM HEART J, V150, P1115, DOI 10.1016/j.ahj.2005.02.007
   Horvitz-Lennon M, 2006, HEALTH AFFAIR, V25, P659, DOI 10.1377/hlthaff.25.3.659
   Hunink MGM, 1997, JAMA-J AM MED ASSOC, V277, P535, DOI 10.1001/jama.277.7.535
   Iestra JA, 2005, CIRCULATION, V112, P924, DOI 10.1161/CIRCULATIONAHA.104.503995
   Jindal RD, 2009, SCHIZOPHR RES, V113, P176, DOI 10.1016/j.schres.2009.06.003
   Jones LE, 2005, PSYCHOSOM MED, V67, P568, DOI 10.1097/01.psy.0000170336.87544.74
   Joukamaa M, 2001, BRIT J PSYCHIAT, V179, P498, DOI 10.1192/bjp.179.6.498
   Khazaal Y, 2007, SCHIZOPHR RES, V91, P169, DOI 10.1016/j.schres.2006.12.025
   Kilbourne AM, 2005, AM J GERIAT PSYCHIAT, V13, P250, DOI 10.1176/appi.ajgp.13.3.250
   Kilbourne AM, 2006, J NERV MENT DIS, V194, P598, DOI 10.1097/01.nmd.0000230637.21821.ec
   Kisely S, 2007, CAN MED ASSOC J, V176, P779, DOI 10.1503/cmaj.060482
   KORANYI EK, 1979, ARCH GEN PSYCHIAT, V36, P414
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Laursen TM, 2007, J CLIN PSYCHIAT, V68, P899, DOI 10.4088/JCP.v68n0612
   Laursen TM, 2009, ARCH GEN PSYCHIAT, V66, P713, DOI 10.1001/archgenpsychiatry.2009.61
   Lawrence DM, 2003, BRIT J PSYCHIAT, V182, P31, DOI 10.1192/bjp.182.1.31
   Li Y, 2007, MED CARE, V45, P587, DOI 10.1097/MLR.0b013e31803d3b54
   Lopez AD, 2006, GLOBAL BURDEN OF DISEASE AND RISK FACTORS, P1, DOI 10.1596/978-0-8213-6262-4
   Lord O, 2010, GEN HOSP PSYCHIAT, V32, P519, DOI 10.1016/j.genhosppsych.2010.04.004
   Mackin P, 2007, BMC PSYCHIATRY, V7, DOI 10.1186/1471-244X-7-28
   Mateen FJ, 2008, PSYCHO-ONCOL, V17, P721, DOI 10.1002/pon.1303
   McDermott S, 2005, COMMUNITY MENT HLT J, V41, P747, DOI 10.1007/s10597-005-6431-6
   McEvoy JP, 2005, SCHIZOPHR RES, V80, P19, DOI 10.1016/j.schres.2005.07.014
   Mitchell AJ, 2009, J CLIN PSYCHOPHARM, V29, P517, DOI 10.1097/JCP.0b013e3181c1b44a
   Mitchell AJ, 2009, BRIT J PSYCHIAT, V194, P491, DOI 10.1192/bjp.bp.107.045732
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Montanez A, 2004, ARCH INTERN MED, V164, P943, DOI 10.1001/archinte.164.9.943
   Morrato EH, 2008, J CLIN PSYCHIAT, V69, P316, DOI 10.4088/JCP.v69n0219
   Morris RW, 2005, HEART, V91, P635, DOI 10.1136/hrt.2004.037507
   Mujica-Parodi LR, 2005, NEUROPSYCHOBIOLOGY, V51, P10, DOI 10.1159/000082850
   Nasrallah HA, 2006, SCHIZOPHR RES, V86, P15, DOI 10.1016/j.schres.2006.06.026
   NEWMAN SC, 1991, CAN J PSYCHIAT, V36, P239, DOI 10.1177/070674379103600401
   Nicholson A, 2006, EUR HEART J, V27, P2763, DOI 10.1093/eurheartj/ehl338
   Osborn DPJ, 2007, ARCH GEN PSYCHIAT, V64, P242, DOI 10.1001/archpsyc.64.2.242
   Osborn DPJ, 2008, BMC PSYCHIATRY, V8, DOI 10.1186/1471-244X-8-84
   Ösby U, 2000, SCHIZOPHR RES, V45, P21, DOI 10.1016/S0920-9964(99)00191-7
   Pendlebury J, 2005, HUM PSYCHOPHARM CLIN, V20, P447, DOI 10.1002/hup.707
   Petersen LA, 2003, HEALTH SERV RES, V38, P41, DOI 10.1111/1475-6773.00104
   Plomondon ME, 2007, BMC HEALTH SERV RES, V7, DOI 10.1186/1472-6963-7-146
   Quatromoni J, 2008, INT J CLIN PRACT, V62, P1910, DOI 10.1111/j.1742-1241.2008.01943.x
   Rasmussen JN, 2007, CARDIOVASC DRUG THER, V21, P449, DOI 10.1007/s10557-007-6058-7
   Ray KK, 2009, LANCET, V373, P1765, DOI 10.1016/S0140-6736(09)60697-8
   Ray WA, 2009, NEW ENGL J MED, V360, P225, DOI 10.1056/NEJMoa0806994
   Roberts L, 2007, FAM PRACT, V24, P34, DOI 10.1093/fampra/cml054
   Rosvall M, 2008, BMC PUBLIC HEALTH, V8, DOI 10.1186/1471-2458-8-44
   Saha S, 2007, ARCH GEN PSYCHIAT, V64, P1123, DOI 10.1001/archpsyc.64.10.1123
   Ruiz JS, 2008, ACTAS ESP PSIQUIATRI, V36, P251
   Schneiderhan ME, 2009, PHARMACOTHERAPY, V29, P975, DOI 10.1592/phco.29.8.975
   Sekhri N, 2008, BMJ-BRIT MED J, V336, P1058, DOI 10.1136/bmj.39534.571042.BE
   Sundquist K, 2006, ACTA PSYCHIAT SCAND, V113, P283, DOI 10.1111/j.1600-0447.2006.00774.x
   Suvisaari J, 2010, PSYCHIAT RES, V175, P126, DOI 10.1016/j.psychres.2008.07.021
   Suvisaari JM, 2007, J CLIN PSYCHIAT, V68, P1045, DOI 10.4088/JCP.v68n0711
   Unützer J, 2006, PSYCHIAT SERV, V57, P37, DOI 10.1176/appi.ps.57.1.37
   Vahia IV, 2008, PSYCHIAT SERV, V59, P853, DOI 10.1176/ps.2008.59.8.853
   van Melle JP, 2004, PSYCHOSOM MED, V66, P814, DOI 10.1097/01.psy.0000146294.82810.9c
   Waterreus AJ, 2009, MED J AUSTRALIA, V190, P185, DOI 10.5694/j.1326-5377.2009.tb02344.x
   Weber M, 2006, SCHIZOPHR RES, V83, P95, DOI 10.1016/j.schres.2006.01.008
   Young JK, 2000, JAMA-J AM MED ASSOC, V283, P3198, DOI 10.1001/jama.283.24.3198
   Zhang J, 1998, JAMA-J AM MED ASSOC, V280, P1690, DOI 10.1001/jama.280.19.1690
NR 101
TC 87
Z9 90
U1 0
U2 18
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1250
EI 1472-1465
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD JUN
PY 2011
VL 198
IS 6
BP 434
EP 441
DI 10.1192/bjp.bp.109.076950
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 778AR
UT WOS:000291669900006
PM 21628705
OA Bronze
DA 2025-06-11
ER

PT J
AU Khalfallah, M
   Habib, M
   Kishk, AM
   Saeed, B
   Hemdan, S
   Eissa, A
   Aboomar, AA
   Hagag, RY
   Elnagar, B
AF Khalfallah, Mohamed
   Habib, Marwa
   Kishk, Ahmed mustafa
   Saeed, Baraka
   Hemdan, Shreen
   Eissa, Ahmad
   Aboomar, Ahmed a.
   Hagag, Rasha youssef
   Elnagar, Basma
TI Atherosclerotic Cardiovascular Diseases in Middle Delta of Egypt: A
   Systematic Analysis of Risk Factors Associated with the Rising Burden of
   the Disease
SO GLOBAL HEART
LA English
DT Article
DE Atherosclerotic cardiovascular diseases; risk factors; Egypt
ID CORONARY-HEART-DISEASE; PREVENTION
AB Background: The popularity of behavioural and metabolic risk factors associated with atherosclerotic cardiovascular diseases (ACVDs) has increased because of social progress, rapid economic development, population aging, and changes in social ideology. We aimed to perform a systematic analysis of risk factors associated with the rising rate of ACVDs in Egypt. Methods: This study was carried out on 1,700 participants. The patients were classified into two groups: group 1 included patients with ACVDs, and group 2 (control group) included healthy individuals. All data recorded included patients' anthropometric measurements, and laboratory and clinical examinations were collected. Results: The rising burden of ACVDs in Egypt was caused by a variety of risk factors, including diabetes mellitus, smoking, hypertension, dyslipidemia, obesity, and a lack of physical activity. The dominant risk factors recognized through multivariate regression analysis were the existence of metabolic syndrome (OR = 1.463; 95% CI, 1.056-2.026; P = 0.022), increased psychosocial stress among the patients (OR = 1.404; 95% CI, 1.008-1.953; P = 0.044), excessive consumption of high-fat, processed, and fast food (OR = 1.964; 95% CI, 1.489-2.590; P = 0.001), and decreased the income (OR = 1.865; 95% CI, 1.454-2.391; P = 0.001). Conclusions: Patients who suffer from uncontrolled diabetes, dyslipidemia, and metabolic syndrome are the most liable to have ACVDs. Psychosocial stress and the excessive intake of processed, high-fat, and fast food are augmenting leading risk features, especially in low-income populations.
C1 [Khalfallah, Mohamed; Habib, Marwa; Elnagar, Basma] Tanta Univ, Fac Med, Cardiovasc Med Dept, Tanta, Egypt.
   [Kishk, Ahmed mustafa] Tanta Univ, Fac Med, Neurol Med Dept, Tanta, Egypt.
   [Saeed, Baraka; Hemdan, Shreen] Family Med & Community Hlth Dept, Abu Dhabi, U Arab Emirates.
   [Eissa, Ahmad; Aboomar, Ahmed a.; Hagag, Rasha youssef] Tanta Univ, Fac Med, Internal Med Dept, Tanta, Egypt.
C3 Egyptian Knowledge Bank (EKB); Tanta University; Egyptian Knowledge Bank
   (EKB); Tanta University; Egyptian Knowledge Bank (EKB); Tanta University
RP Khalfallah, M (corresponding author), Tanta Univ, Fac Med, Cardiovasc Med Dept, Tanta, Egypt.
EM khalfallah@yahoo.com
RI habib, Marwa/KRR-2042-2024; Hagag, Rasha/JZT-5241-2024; elnagar,
   basma/JKJ-4690-2023; khalfallah, mohamed/AAN-3560-2020; Kishk, Ahmed
   Mustafa/LKO-0848-2024
OI Khalfallah, Mohamed/0000-0002-6105-9300
CR Abd El-Gawad HN, 2022, JRAM, V3, P119, DOI [10.21608/jram.2021.104011.1146, DOI 10.21608/JRAM.2021.104011.1146]
   Ali MK, 2010, INDIAN J MED RES, V132, P584
   An SJ, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0208189
   [Anonymous], 2020, WHO
   Bahnasawy MH, 2013, Egypt J Hosp Med, V53, P827, DOI [10.12816/0001645, DOI 10.12816/0001645]
   Belli M, 2023, ACTA DIABETOL, V60, P1291, DOI 10.1007/s00592-023-02097-w
   Cai JJ, 2019, ANNU REV PATHOL-MECH, V14, P153, DOI 10.1146/annurev-pathmechdis-012418-013003
   Chandola T, 2008, EUR HEART J, V29, P640, DOI 10.1093/eurheartj/ehm584
   Cimmino G, 2023, BIOMEDICINES, V11, DOI 10.3390/biomedicines11092353
   Flack JM, 2020, TRENDS CARDIOVAS MED, V30, P160, DOI 10.1016/j.tcm.2019.05.003
   Gaidai O, 2023, CURR PROB CARDIOLOGY, V48, DOI 10.1016/j.cpcardiol.2023.101622
   Galicia-Garcia U, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21176275
   Gatto L, 2020, EUR HEART J SUPPL, V22, pE87, DOI 10.1093/eurheartj/suaa068
   Gilbert-Ouimet M, 2022, J HUM HYPERTENS, V36, P207, DOI 10.1038/s41371-021-00499-3
   Harris KM, 2023, ANN BEHAV MED, V57, P846, DOI 10.1093/abm/kaad015
   Jebari-Benslaiman S, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23063346
   Khan MAB, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.9349
   Li YT, 2022, FRONT PUBLIC HEALTH, V10, DOI 10.3389/fpubh.2022.973317
   Mehta PK, 2022, CURR CARDIOL REP, V24, P2109, DOI 10.1007/s11886-022-01821-2
   Mills KT, 2020, NAT REV NEPHROL, V16, P223, DOI 10.1038/s41581-019-0244-2
   Mumena WA, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph192215083
   Prabhakaran D, 2017, Cardiovascular, Respiratory, and Related Disorders
   Prabhakaran D, 2016, CIRCULATION, V133, P1605, DOI 10.1161/CIRCULATIONAHA.114.008729
   Ralapanawa U, 2021, J EPIDEMIOL GLOB HEA, V11, P169, DOI 10.2991/jegh.k.201217.001
   Ramadan A, 2024, CUREUS J MED SCIENCE, V16, DOI 10.7759/cureus.58024
   Reiner Z, 2021, INT J CARDIOL, V322, P227, DOI 10.1016/j.ijcard.2020.09.004
   Rippe JM, 2019, AM J LIFESTYLE MED, V13, P204, DOI 10.1177/1559827618812395
   Satyjeet FNU, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.10757
   Schultz WM, 2018, CIRCULATION, V137, P2166, DOI 10.1161/CIRCULATIONAHA.117.029652
   Sedky A, 2021, American University in Cairo AUC Knowledge Fountain
   Thomas H, 2018, GLOB HEART, V13, P143, DOI 10.1016/j.gheart.2018.09.511
   Valenzuela PL, 2023, EUR J PREV CARDIOL, V30, P1493, DOI 10.1093/eurjpc/zwad204
   Verma S, 2023, CIRCULATION, V147, P1251, DOI 10.1161/CIRCULATIONAHA.123.064345
   Walli-Attaei M, 2022, LANCET, V400, P811, DOI 10.1016/S0140-6736(22)01441-6
   Wang WX, 2021, CELL METAB, V33, P1943, DOI 10.1016/j.cmet.2021.08.005
   WHO Consultation, 2000, WHO TECH REP SER, V894, P1
   Gowdak LHW, 2020, ARQ BRAS CARDIOL, V114, P273, DOI 10.36660/abc.20200038
   Yu E, 2018, J AM COLL CARDIOL, V72, P914, DOI 10.1016/j.jacc.2018.02.085
   Zhang B, 2017, BIOMED ENG ONLINE, V16, DOI 10.1186/s12938-017-0425-9
   Zhou JH, 2020, HEPATOLOGY, V71, P1851, DOI 10.1002/hep.31150
NR 40
TC 1
Z9 1
U1 0
U2 0
PU UBIQUITY PRESS LTD
PI LONDON
PA Unit 3N, 6 Osborn Street, LONDON, E1 6TD, ENGLAND
SN 2211-8160
EI 2211-8179
J9 GLOB HEART
JI Glob. Heart
PY 2025
VL 20
IS 1
AR 11
DI 10.5334/gh.1395
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA X0A1F
UT WOS:001422075700005
PM 39925839
OA gold
DA 2025-06-11
ER

PT J
AU Macaluso, M
   Bianchi, A
   Sanmartin, C
   Taglieri, I
   Venturi, F
   Testai, L
   Flori, L
   Calderone, V
   De Leo, M
   Braca, A
   Ciccone, V
   Donnini, S
   Guidi, L
   Zinnai, A
AF Macaluso, Monica
   Bianchi, Alessandro
   Sanmartin, Chiara
   Taglieri, Isabella
   Venturi, Francesca
   Testai, Lara
   Flori, Lorenzo
   Calderone, Vincenzo
   De Leo, Marinella
   Braca, Alessandra
   Ciccone, Valerio
   Donnini, Sandra
   Guidi, Luca
   Zinnai, Angela
TI By-Products from Winemaking and Olive Mill Value Chains for the
   Enrichment of Refined Olive Oil: Technological Challenges and
   Nutraceutical Features
SO FOODS
LA English
DT Article
DE phenol-enriched olive oil; grape marc; olive pomace; olive leaves;
   phenols; in vitro model; in vivo model; cardiovascular diseases; cancer
   diseases; metabolic syndrome
ID OWN PHENOLIC-COMPOUNDS; WASTE-WATER; VIRGIN; ANTIOXIDANTS;
   HYDROXYTYROSOL; STABILIZATION; INFLAMMATION; POLYPHENOLS; EXTRACTION;
   STABILITY
AB A growing body of literature is available about the valorization of food by-products to produce functional foods that combine the basic nutritional impact with the improvement of the health status of consumers. In this context, this study had two main objectives: (i) An innovative multistep extraction process for the production of a refined olive oil enriched with phenolic compounds (PE-ROO) extracted from olive pomace, olive leaves, or grape marc was presented and discussed. (ii) The most promising PE-ROOs were selected and utilized in in vitro and in vivo trials in order to determine their effectiveness in the management of high fat diet-induced-metabolic syndrome and oxidative stress in rats. The best results were obtained when olive leaves were used as source of phenols, regardless of the chemical composition of the solvent utilized for the extraction. Furthermore, while ethanol/hexane mixture was confirmed as a good solvent for the extraction of phenols compounds soluble in oil, the mix ROO/ethanol also showed a good extracting power from olive leaves. Besides, the ROO enriched with phenols extracted from olive leaves revealed an interesting beneficial effect to counteract high fat diet-induced-metabolic disorder and oxidative stress in rats, closely followed by ROO enriched by utilizing grape marc.
C1 [Macaluso, Monica; Bianchi, Alessandro; Sanmartin, Chiara; Taglieri, Isabella; Venturi, Francesca; Zinnai, Angela] Univ Pisa, Dept Agr Food & Environm DAFE, Via Borghetto 80, I-56124 Pisa, Italy.
   [Sanmartin, Chiara; Venturi, Francesca; Testai, Lara; Calderone, Vincenzo; De Leo, Marinella; Braca, Alessandra; Zinnai, Angela] Univ Pisa, Interdept Res Ctr Nutraceut & Food Hlth, Via Borghetto 80, I-56124 Pisa, Italy.
   [Venturi, Francesca; De Leo, Marinella; Braca, Alessandra; Zinnai, Angela] Pisa Univ, Ctr Instrumentat Sharing, CISUP, Lungarno Pacinotti 43, I-56126 Pisa, Italy.
   [Testai, Lara; Calderone, Vincenzo; De Leo, Marinella; Braca, Alessandra; Ciccone, Valerio] Univ Pisa, Dept Pharm, Via Bonanno Pisano 6, I-56126 Pisa, Italy.
   [Flori, Lorenzo; Donnini, Sandra] Univ Siena, Dept Life Sci, Via Aldo Moro 2, I-53100 Siena, Italy.
   [Ciccone, Valerio; Donnini, Sandra] Toscana Life Sci, Str Petriccio & Belriguardo 35, I-53100 Siena, Italy.
   [Guidi, Luca] SALOV SpA, Via Montramito 1600, I-55054 Massarosa, Italy.
C3 University of Pisa; University of Pisa; University of Pisa; University
   of Pisa; University of Siena
RP Sanmartin, C; Taglieri, I (corresponding author), Univ Pisa, Dept Agr Food & Environm DAFE, Via Borghetto 80, I-56124 Pisa, Italy.; Sanmartin, C (corresponding author), Univ Pisa, Interdept Res Ctr Nutraceut & Food Hlth, Via Borghetto 80, I-56124 Pisa, Italy.
EM monica.macaluso@phd.unipi.it; alessandra.braca@unipi.it;
   chiara.sanmartin@unipi.it; Isabella.taglieri@for.unipi.it;
   francesca.venturi@unipi.it; lara.testai@unipi.it;
   lorenzo.flori@phd.unipi.it; vincenzo.calderone@unipi.it;
   marinella.deleo@unipi.it; alessandra.braca@unipi.it;
   vincenzo.calderone@unipi.it; sandra.donnini@unisi.it;
   luca.guidi@salov.com; angela.zinnai@unipi.it
RI Ciccone, Valerio/AAT-1508-2021; guidi, lucia/ABZ-9443-2022; Bianchi,
   Alessandro/AHC-3063-2022; Donnini, Sandra/K-9252-2019; Taglieri,
   Isabella/AAA-4892-2019; Venturi, Francesca/O-8348-2016; SANMARTIN,
   CHIARA/F-7524-2017; CALDERONE, VINCENZO/L-9288-2015
OI Venturi, Francesca/0000-0002-7844-3253; testai,
   lara/0000-0003-2431-6248; SANMARTIN, CHIARA/0000-0002-7559-1955; Flori,
   Lorenzo/0000-0001-7899-0954; De Leo, Marinella/0000-0002-5544-8457;
   Ciccone, Valerio/0000-0002-5374-9694; Monica,
   Macaluso/0000-0001-7075-4252; Donnini, Sandra/0000-0001-6617-1644;
   BRACA, ALESSANDRA/0000-0002-9838-0448; Taglieri,
   Isabella/0000-0001-6000-9371; Bianchi, Alessandro/0000-0001-6482-527X;
   CALDERONE, VINCENZO/0000-0002-1441-5421
FU Regione Toscana: VALE Project (Grant 1 "Progetti di ricerca e sviluppo",
   FESR 2014-2020) [CUP D56G18000160009]
FX This research was funded by Regione Toscana: VALE Project (Grant 1
   "Progetti di ricerca e sviluppo", FESR 2014-2020, cod. CUP
   D56G18000160009).
CR Aparicio-Ruiz R, 2017, FOOD CHEM, V220, P42, DOI 10.1016/j.foodchem.2016.09.176
   Ascrizzi R, 2019, MOLECULES, V24, DOI 10.3390/molecules24010065
   Bagetta D, 2020, EUR J MED CHEM, V186, DOI 10.1016/j.ejmech.2019.111903
   Bellumori M, 2019, MOLECULES, V24, DOI 10.3390/molecules24112179
   Bouaziz M, 2008, FOOD CHEM, V108, P253, DOI 10.1016/j.foodchem.2007.10.074
   BRAND-WILLIAMS W, 1995, FOOD SCI TECHNOL-LEB, V28, P25
   Celano R, 2018, J AGR FOOD CHEM, V66, P6053, DOI 10.1021/acs.jafc.8b01751
   Cinelli G, 2019, COLLOID INTERFAC, V3, DOI 10.3390/colloids3030059
   Cuomo F, 2020, COLLOID INTERFAC, V4, DOI 10.3390/colloids4020023
   De La Torre-Carbot K, 2005, J AGR FOOD CHEM, V53, P4331, DOI 10.1021/jf0501948
   Di Nunzio M, 2020, FOOD RES INT, V131, DOI 10.1016/j.foodres.2019.108940
   Di Nunzio M, 2018, FOOD RES INT, V113, P392, DOI 10.1016/j.foodres.2018.07.025
   Dierkes G, 2012, J AGR FOOD CHEM, V60, P7597, DOI 10.1021/jf3020574
   *EU, 2013, OFF J EUR UNION, P31
   Fki I, 2005, FOOD CHEM, V93, P197, DOI 10.1016/j.foodchem.2004.09.014
   Flori L, 2020, NUTRIENTS, V12, DOI 10.3390/nu12061557
   Flori L, 2019, NUTRIENTS, V11, DOI 10.3390/nu11091962
   Galanakis CM, 2018, ENVIRON TECHNOL INNO, V10, P62, DOI 10.1016/j.eti.2018.01.012
   García A, 2006, J AM OIL CHEM SOC, V83, P159, DOI 10.1007/s11746-006-1189-8
   Garcia R, 2013, FOOD RES INT, V54, P2039, DOI 10.1016/j.foodres.2013.05.008
   García-Villalba R, 2010, J PHARMACEUT BIOMED, V51, P416, DOI 10.1016/j.jpba.2009.06.021
   Garrido M, 2013, J SCI FOOD AGR, V93, P1820, DOI 10.1002/jsfa.5972
   Gavahian M, 2019, TRENDS FOOD SCI TECH, V88, P220, DOI 10.1016/j.tifs.2019.03.008
   Gomes T, 2010, NONCONVENTIONAL PARA
   Grosso G, 2017, CRIT REV FOOD SCI, V57, P3218, DOI 10.1080/10408398.2015.1107021
   Hidalgo M, 2014, FOOD RES INT, V64, P553, DOI 10.1016/j.foodres.2014.07.030
   Incalza MA, 2018, VASC PHARMACOL, V100, P1, DOI 10.1016/j.vph.2017.05.005
   Kehili M, 2019, FOOD BIOPROD PROCESS, V117, P321, DOI 10.1016/j.fbp.2019.08.004
   Kehili M, 2018, FOOD CHEM, V246, P295, DOI 10.1016/j.foodchem.2017.11.034
   Muhlack RA, 2018, WASTE MANAGE, V72, P99, DOI 10.1016/j.wasman.2017.11.011
   Nunes MA, 2016, INNOV FOOD SCI EMERG, V35, P139, DOI 10.1016/j.ifset.2016.04.016
   Olmo-García L, 2018, MOLECULES, V23, DOI 10.3390/molecules23102419
   Persuric Z, 2020, LWT-FOOD SCI TECHNOL, V125, DOI 10.1016/j.lwt.2020.109225
   Qi J, 2020, J DIABETES RES, V2020, DOI 10.1155/2020/2308520
   Quirantes-Piné R, 2013, PHYTOCHEM ANALYSIS, V24, P213, DOI 10.1002/pca.2401
   Reboredo-Rodríguez P, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18030668
   Rekik O, 2018, ELECTROPHORESIS, V39, P1663, DOI 10.1002/elps.201700200
   ROSALES FG, 1992, J AM OIL CHEM SOC, V69, P394, DOI 10.1007/BF02636076
   Rosenblat M, 2008, J NUTR BIOCHEM, V19, P514, DOI 10.1016/j.jnutbio.2007.06.007
   Rubió L, 2012, J AGR FOOD CHEM, V60, P3105, DOI 10.1021/jf204902w
   de Medina VS, 2012, J AGR FOOD CHEM, V60, P5866, DOI 10.1021/jf301161v
   de Medina VS, 2011, J AGR FOOD CHEM, V59, P11432, DOI 10.1021/jf2020528
   Schwingshackl L, 2019, NUTR METAB CARDIOVAS, V29, P1030, DOI 10.1016/j.numecd.2019.07.001
   Sgherri C, 2016, AGROCHIMICA, V60, P312, DOI 10.12871/00021857201646
   Silva S, 2015, J NUTR BIOCHEM, V26, P360, DOI 10.1016/j.jnutbio.2014.11.011
   Sukovi D., 2020, MONTENEGRO FOODS, V9, P138, DOI [10.3390/foods902013832012995, DOI 10.3390/FOODS902013832012995]
   Valls RM, 2015, FOOD CHEM, V167, P30, DOI 10.1016/j.foodchem.2014.06.107
   Venturi F, 2015, AGROCHIMICA, V59, P261
   Venturi F, 2019, APPL SCI-BASEL, V9, DOI 10.3390/app9122431
   Venturi F, 2017, NUTRIENTS, V9, DOI 10.3390/nu9080916
   Venturi F, 2017, APPL SCI-BASEL, V7, DOI 10.3390/app7040361
   Wang W, 2019, ENVIRON INT, V128, P24, DOI 10.1016/j.envint.2019.04.028
   Ye XW, 2013, J ACAD NUTR DIET, V113, P276, DOI 10.1016/j.jand.2012.10.014
NR 53
TC 14
Z9 14
U1 0
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD OCT
PY 2020
VL 9
IS 10
AR 1390
DI 10.3390/foods9101390
PG 21
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA OL5KL
UT WOS:000585378600001
PM 33019655
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vahedian, Z
   Fakhraie, G
   Bovet, J
   Mozaffarieh, M
AF Vahedian, Zakieh
   Fakhraie, Ghasem
   Bovet, Jerome
   Mozaffarieh, Maneli
TI Nutritional recommendations for individuals with Flammer syndrome
SO EPMA JOURNAL
LA English
DT Review
DE Preventive; Personalized; Flammer syndrome; Oxidative stress;
   Antioxidative nutrition
ID GINKGO-BILOBA-EXTRACT; ZINC-CHELATING SUBSTANCE; RETINAL
   VENOUS-PRESSURE; RED WINE POLYPHENOLS; ANTIOXIDANT CAPACITY;
   BORAGO-OFFICINALIS; DARK CHOCOLATE; BLOOD-PRESSURE; VISUAL-FIELD;
   CIRCULATING LEUKOCYTES
AB The Flammer syndrome (FS) describes the phenotype of people with a predisposition for an altered reaction of the blood vessels to stimuli like coldness or emotional stress. The question whether such people should be treated is often discussed. On the one hand, most of these subjects are healthy; on the other hand, FS seems to predispose to certain eye diseases such as normal tension glaucoma or retinitis pigmentosa or systemic diseases such as multiple sclerosis or tinnitus. A compromise between doing nothing and a drug treatment is the adaption of nutrition. But what do we mean by healthy food consumption for subjects with FS? The adaption of nutrition depends on the health condition. Whereas patients with e.g. a metabolic syndrome should reduce their calorie intake, this can be counterproductive for subjects with FS, as most subjects with FS have already a low body mass index (BMI) and the lower the BMI the stronger the FS symptoms. Accordingly, while fasting is healthy e.g. for subjects with metabolic syndrome, fasting can even dangerously aggravate the vascular dysregulation, as it has been nicely demonstrated by the loss of retinal vascular regulation during fasting. To give another example, while reducing salt intake is recommended for subjects with systemic hypertensions, such a salt restriction can aggravate systemic hypotension and thereby indirectly also the vascular regulation in subjects with FS. This clearly demonstrates that such a preventive adaption of nutrition needs to be personalized.
C1 [Vahedian, Zakieh; Fakhraie, Ghasem] Univ Tehran Med Sci, Farabi Eye Hosp, Glaucoma Serv, Tehran, Iran.
   [Bovet, Jerome; Mozaffarieh, Maneli] Augen Glattzentrum, Zurich, Switzerland.
   [Mozaffarieh, Maneli] Univ Basel, Dept Ophthalmol, Mittlere Str 91, CH-4031 Basel, Switzerland.
C3 Tehran University of Medical Sciences; Farabi Eye Hospital; University
   of Basel
RP Mozaffarieh, M (corresponding author), Augen Glattzentrum, Zurich, Switzerland.; Mozaffarieh, M (corresponding author), Univ Basel, Dept Ophthalmol, Mittlere Str 91, CH-4031 Basel, Switzerland.
EM vahedian.z@gmail.com; gfakhraie@gmail.com; jbovet@vision.tv;
   maneli.mozaffarieh@gmail.com
CR Abdel-Kader R, 2007, PHARMACOL RES, V56, P493, DOI 10.1016/j.phrs.2007.09.011
   Abolhassani M, 2010, ARCH MED SCI, V6, P366, DOI 10.5114/aoms.2010.14256
   Al-Khamees WA, 2011, J MED TOXICOL, V7, P154, DOI 10.1007/s13181-011-0135-9
   Almoosawi S, 2010, BRIT J NUTR, V103, P842, DOI 10.1017/S0007114509992431
   Asadi-Samani M, 2014, ASIAN PAC J TROP MED, V7, pS22, DOI 10.1016/S1995-7645(14)60199-1
   Asadollahi F, 2015, J PHOTOCH PHOTOBIO B, V151, P270, DOI 10.1016/j.jphotobiol.2015.08.023
   Bamford JTM, 2013, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004416.pub2
   Bujor OC, 2016, FOOD CHEM, V213, P58, DOI 10.1016/j.foodchem.2016.06.042
   Casanova MA, 2017, J AM SOC HYPERTENS, V11, P10, DOI 10.1016/j.jash.2016.10.004
   Cha SH, 2001, J NUTR, V131, P2636, DOI 10.1093/jn/131.10.2636
   Chung HS, 1999, J OCUL PHARMACOL TH, V15, P233, DOI 10.1089/jop.1999.15.233
   Clostre F, 2001, THERAPIE, V56, P595
   Coudray C, 2005, MAGNESIUM RES, V18, P215
   D'Souza HP, 2006, INDIAN J CLIN BIOCHE, V21, P138, DOI 10.1007/BF02912929
   Dettmann ES, 1998, GRAEF ARCH CLIN EXP, V236, P47, DOI 10.1007/s004170050041
   DROYLEFAIX MT, 1995, TRANSPLANT P, V27, P2861
   Duluc L, 2013, INT J BIOCHEM CELL B, V45, P783, DOI 10.1016/j.biocel.2013.01.007
   Eckert A, 2003, PHARMACOPSYCHIATRY, V36, pS15
   Eckert A, 2012, INT PSYCHOGERIATR, V24, pS18, DOI 10.1017/S1041610212000531
   ENGLER MB, 1992, CARDIOVASC DRUG THER, V6, P605, DOI 10.1007/BF00052562
   Fang L, 2015, GRAEF ARCH CLIN EXP, V253, P935, DOI 10.1007/s00417-015-3001-7
   Fang L, 2015, EXPERT REV OPHTHALMO, V10, P313, DOI 10.1586/17469899.2015.1043994
   Fang L, 2014, BMC OPHTHALMOL, V14, DOI 10.1186/1471-2415-14-121
   Flammer AJ, 2007, CIRCULATION, V116, P2376, DOI 10.1161/CIRCULATIONAHA.107.713867
   Flammer AJ, 2012, EUR HEART J, V33, P2172, DOI 10.1093/eurheartj/ehr448
   Flammer J, 2013, SPRINGER SCI BUSINES, P160
   Flammer J., 2009, European Ophthalmic Review, V3, P33, DOI DOI 10.17925/EOR.2009.03.01.33
   GASPAR AZ, 1995, OPHTHALMOLOGICA, V209, P11, DOI 10.1159/000310566
   Gauthier S, 2014, CLIN INTERV AGING, V9, P2065, DOI 10.2147/CIA.S72728
   Gilani AH, 2007, J ETHNOPHARMACOL, V114, P393, DOI 10.1016/j.jep.2007.08.032
   Golubnitschaja O, 2016, EPMA J, V7, DOI 10.1186/s13167-016-0072-4
   Gomes SMC, 2016, TALANTA, V154, P284, DOI 10.1016/j.talanta.2016.03.083
   Gramza-Michalowska A, 2016, FOOD CHEM, V211, P448, DOI 10.1016/j.foodchem.2016.05.048
   Grassi D, 2008, J NUTR, V138, P1671, DOI 10.1093/jn/138.9.1671
   Harvey LD, 2015, ASN NEURO, V7, DOI 10.1177/1759091415618969
   Hayek T, 1997, ARTERIOSCL THROM VAS, V17, P2744, DOI 10.1161/01.ATV.17.11.2744
   Heiss C, 2015, AGE, V37, DOI 10.1007/s11357-015-9794-9
   Hernández-Jiménez A, 2013, J ANAL METHODS CHEM, V2013, DOI 10.1155/2013/572896
   Hooshmand S, 2015, FOOD FUNCT, V6, P1719, DOI [10.1039/c5fo00173k, 10.1039/C5FO00173K]
   Hoshi T, 2013, P NATL ACAD SCI USA, V110, P4816, DOI 10.1073/pnas.1221997110
   Izzo Angelo A., 1996, Magnesium Research, V9, P133
   Karim M, 2000, J NUTR, V130, p2105S, DOI 10.1093/jn/130.8.2105S
   Kaur P, 2012, CHEM BIODIVERS, V9, P409, DOI 10.1002/cbdv.201100082
   Khatun M, 2006, FOOD SCI TECHNOL RES, V12, P178, DOI 10.3136/fstr.12.178
   Kim AR, 2002, J PHARM PHARMACOL, V54, P1385, DOI 10.1211/002235702760345473
   Kim SY, 1998, OPHTHALMOLOGICA, V212, P268, DOI 10.1159/000027305
   Koch E, 2005, PHYTOMEDICINE, V12, P10, DOI 10.1016/j.phymed.2004.02.002
   Koczka N, 2015, ACTA PHARMACEUT, V65, P99, DOI 10.1515/acph-2015-0001
   Konieczka K, 2014, EPMA J, V5, DOI 10.1186/1878-5085-5-11
   Krishnan KR, 2014, INT J FOOD MICROBIOL, V171, P32, DOI 10.1016/j.ijfoodmicro.2013.11.011
   Lançon A, 2016, MOLECULES, V21, DOI 10.3390/molecules21030304
   Lee J, 2013, J GLAUCOMA, V22, P780, DOI 10.1097/IJG.0b013e3182595075
   Lee KW, 2003, J AGR FOOD CHEM, V51, P7292, DOI 10.1021/jf0344385
   Li CC, 2014, J NUTR BIOCHEM, V25, P19, DOI 10.1016/j.jnutbio.2013.08.010
   López-Sepúlveda R, 2008, HYPERTENSION, V51, P1088, DOI 10.1161/HYPERTENSIONAHA.107.107672
   López-Sepúlveda R, 2011, CLIN SCI, V120, P321, DOI 10.1042/CS20100311
   Mamun S, 2012, Malays J Nutr, V18, P355
   Martinez-López S, 2014, FOOD FUNCT, V5, P364, DOI 10.1039/c3fo60352k
   Mattila P, 2006, J AGR FOOD CHEM, V54, P7193, DOI 10.1021/jf0615247
   Medeiros ND, 2015, BIOCHEM RES INT, V2015, DOI 10.1155/2015/294659
   MORGADO PB, 1994, OPHTHALMOLOGY, V101, P1220
   Morteza E, 2015, NAT PROD RES, V29, P663, DOI 10.1080/14786419.2014.971793
   Mozaffarieh M, 2008, SURV OPHTHALMOL, V53, P479, DOI 10.1016/j.survophthal.2008.06.006
   Mozaffarieh M, 2008, MOL VIS, V14, P1584
   Mozaffarieh M., 2013, OXID ANTIOXID MED SC, V2, P155
   Mozaffarieh M., 2009, Ocular blood flow and glaucomatous optic neuropathy
   Mozaffarieh M, 2007, SURV OPHTHALMOL, V52, pS174, DOI 10.1016/j.survophthal.2007.08.013
   Mozaffarieh M, 2007, EXPERT OPIN EMERG DR, V12, P195, DOI 10.1517/14728214.12.2.195
   Mozaffarieh M, 2013, CURR OPIN PHARMACOL, V13, P43, DOI 10.1016/j.coph.2012.10.001
   Mozaffarieh M, 2010, EPMA J, V1, P229, DOI 10.1007/s13167-010-0018-1
   Mozaffarieh Maneli, 2010, Tob Induc Dis, V8, P14, DOI 10.1186/1617-9625-8-14
   Mozaffarieh M, 2010, POPUL HEALTH METR, V8, DOI 10.1186/1478-7954-8-17
   Nakagawa T, 2002, FOOD CHEM TOXICOL, V40, P1745, DOI 10.1016/S0278-6915(02)00169-2
   Neilson AP, 2006, J CHROMATOGR A, V1132, P132, DOI 10.1016/j.chroma.2006.07.059
   Niedzwiecki A, 2016, NUTRIENTS, V8, DOI 10.3390/nu8090552
   Oszmianski J, 2016, MOLECULES, V21, DOI 10.3390/molecules21081098
   Otunola GA, 2014, BIOL RES, V47, DOI 10.1186/0717-6287-47-5
   Ou HC, 2009, J APPL PHYSIOL, V106, P1674, DOI 10.1152/japplphysiol.91415.2008
   Park JY, 2011, J MECH SCI TECHNOL, V25, P323, DOI [10.3341/kjo.2011.25.5.323, 10.1007/s12206-010-1218-2]
   Patay ÉB, 2016, ASIAN PAC J TROP MED, V9, P356, DOI 10.1016/j.apjtm.2016.03.014
   Peluso I, 2017, BRIT J PHARMACOL, V174, P1195, DOI 10.1111/bph.13649
   Pierre SV, 2008, CELL MOL BIOL, V54, P1032, DOI 10.1170/118
   Piljac-Zegarac J, 2009, J MED FOOD, V12, P608, DOI 10.1089/jmf.2008.0081
   Polidori D, 2016, OBESITY, V24, P2289, DOI 10.1002/oby.21653
   Quaranta L, 2003, OPHTHALMOLOGY, V110, P359, DOI 10.1016/S0161-6420(02)01745-1
   Ranade V V, 2001, Am J Ther, V8, P345, DOI 10.1097/00045391-200109000-00008
   Rassaf T, 2016, CLIN J AM SOC NEPHRO, V11, P108, DOI 10.2215/CJN.05560515
   Rodríguez JC, 2016, J AGR FOOD CHEM, V64, P852, DOI 10.1021/acs.jafc.5b04990
   Roura E, 2007, ANN NUTR METAB, V51, P493, DOI 10.1159/000111473
   Rull G, 2015, VASC PHARMACOL, V71, P70, DOI 10.1016/j.vph.2015.02.010
   Scoditti E, 2012, ARCH BIOCHEM BIOPHYS, V527, P81, DOI 10.1016/j.abb.2012.05.003
   Seeram NP, 2008, J AGR FOOD CHEM, V56, P1415, DOI 10.1021/jf073035s
   Segovia F, 2014, ANTIOXIDANTS-BASEL, V3, P339, DOI 10.3390/antiox3020339
   Shen JM, 2016, NEUROSCIENCE, V334, P226, DOI 10.1016/j.neuroscience.2016.08.013
   STADLER RH, 1994, MUTAT RES, V308, P177, DOI 10.1016/0027-5107(94)90153-8
   Strike PC, 2003, EUR HEART J, V24, P690, DOI 10.1016/S0195-668X(02)00615-2
   Sun BN, 2003, P NATL ACAD SCI USA, V100, P7141, DOI 10.1073/pnas.1232419100
   Teuchner B, 2004, ACTA OPHTHALMOL SCAN, V82, P738, DOI 10.1111/j.1600-0420.2004.00376.x
   Tulsulkar J, 2013, NEUROCHEM INT, V62, P189, DOI 10.1016/j.neuint.2012.11.017
   Vahedian Z, 2015, EPMA J, V6, DOI 10.1186/s13167-015-0031-5
   van Golde PHM, 1999, ATHEROSCLEROSIS, V147, P365
   Verna R, 2013, MALAY J PATHOL, V35, P111
   von Holst C, 2016, FOOD ADDIT CONTAM A, V33, P66, DOI 10.1080/19440049.2015.1116127
   Wang CZ, 2015, MOLECULES, V20, P22257, DOI 10.3390/molecules201219839
   Wen X, 2005, J AGR FOOD CHEM, V53, P2684, DOI 10.1021/jf048304i
   Wen X, 2004, BIOSCI BIOTECH BIOCH, V68, P2313, DOI 10.1271/bbb.68.2313
   Wu YT, 2016, BIOTECHNOL PROGR, V32, P735, DOI 10.1002/btpr.2255
   Wu YZ, 2008, PHYTOMEDICINE, V15, P164, DOI 10.1016/j.phymed.2007.12.002
   Wunderlich K, 2003, MOL VIS, V9, P756
   Xie HY, 2014, MOLECULES, V19, P4466, DOI 10.3390/molecules19044466
   Yammine L, 2014, PSYCHOSOM MED, V76, P109, DOI 10.1097/PSY.0000000000000026
   Yoon AMC, 2016, ANN ALLERG ASTHMA IM, V117, P359, DOI 10.1016/j.anai.2016.08.021
   Zhao BL, 2001, METHOD ENZYMOL, V335, P217
   Zhao RX, 2017, INT J CARDIOL, V226, P110, DOI 10.1016/j.ijcard.2016.10.053
NR 114
TC 3
Z9 3
U1 0
U2 17
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1878-5077
EI 1878-5085
J9 EPMA J
JI EPMA J.
PD JUN
PY 2017
VL 8
IS 2
BP 187
EP 195
DI 10.1007/s13167-017-0093-7
PG 9
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA FB0KI
UT WOS:000405833600010
PM 28824740
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Hayden, MR
   Banks, WA
   Shah, GN
   Gu, Z
   Sowers, JR
AF Hayden, M. R.
   Banks, W. A.
   Shah, G. N.
   Gu, Z.
   Sowers, J. R.
TI Cardiorenal Metabolic Syndrome and Diabetic Cognopathy
SO CARDIORENAL MEDICINE
LA English
DT Article
DE Diabetic cognopathy; Alzheimer's disease; Type 2 diabetes mellitus;
   Ultrastructure; Remodeling; Neurovascular unit; Blood-brain barrier
ID BLOOD-BRAIN-BARRIER; RENIN-ANGIOTENSIN SYSTEM; CALCIFIC UREMIC
   ARTERIOLOPATHY; CHRONIC KIDNEY-DISEASE; ALZHEIMERS-DISEASE; VASCULAR
   DEMENTIA; COGNITIVE IMPAIRMENT; OXIDATIVE STRESS; PERICYTES; MELLITUS
AB The prevalence of the cardiorenal metabolic syndrome (CRS) is increasing in parallel with obesity, type 2 diabetes mellitus, Alzheimer's disease, and other forms of dementia. Along with metabolic, inflammatory, and immunological abnormalities, there is maladaptive structural remodeling of the heart, kidney, and brain. The term 'diabetic cognopathy' (DC) may be used when discussing functional and structural changes in the brain of the diabetic patient. DC likely represents an advanced form of these changes in the brain that evolve with increasing duration of the CRS and subsequent clinical diabetes. We posit that DC develops due to a convergence of aging, genetic and lifestyle abnormalities (overnutrition and lack of exercise), which result in multiple injurious metabolic and immunologic toxicities such as dysfunctional immune responses, oxidative stress, inflammation, insulin resistance, and dysglycemia (systemically and in the brain). These converging abnormalities may lead to endothelial blood-brain barrier tight junction/adherens junction (TJ/AJ) complex remodeling and microglia activation, which may result in neurodegeneration, impaired cognition, and dementia. Herein, we describe the brain ultrastructural changes evolving from a normal state to maladaptive remodeling in rodent models of CRS including microglia activation/polarization and attenuation and/or loss of the TJ/AJ complexes, pericytes and astrocytes of the neurovascular unit. Further, we discuss the potential relationship between these structural changes and the development of DC, potential therapeutic strategies, and future directions. (C) 2013 S. Karger AG, Basel
C1 [Hayden, M. R.; Sowers, J. R.] Univ Missouri, Dept Internal Med, Div Endocrinol Diabet & Metab, Columbia, MO 65212 USA.
   [Hayden, M. R.; Gu, Z.; Sowers, J. R.] Univ Missouri, Diabet & Cardiovasc Res Lab, Columbia, MO 65212 USA.
   [Sowers, J. R.] Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO 65212 USA.
   [Sowers, J. R.] Harry S Truman Mem Vet Hosp, Columbia, MO 65201 USA.
   [Banks, W. A.] Univ Washington, Dept Med, Div Geriatr Med, Vet Affairs Puget Sound Hlth Care Syst,Geriat Res, Seattle, WA USA.
   [Shah, G. N.] St Louis Univ, Dept Internal Med, Div Endocrinol, St Louis, MO 63103 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); Vet Affairs Puget Sound
   Health Care System; University of Washington; University of Washington
   Seattle; Saint Louis University
RP Hayden, MR (corresponding author), Univ Missouri, D109 Diabet Ctr HSC,1 Hosp Dr, Columbia, MO 65212 USA.
EM mrh29@usmo.com
RI Banks, William/K-1330-2017; Hayden, Michael/D-8581-2011
FU NIH [R01 HL73101-01A1, R01 HL107910-01]; Veterans Affairs Merit System
   [0018]
FX The authors would like to acknowledge Tommi White, PhD, of the
   University of Missouri Electron Microscopic Core Facility, Columbia,
   Mo., USA, for preparing and staining the transmission electron
   microscopic images for viewing. We wish to acknowledge Brenda Hunter for
   her editorial assistance. The work presented is supported by the NIH
   (R01 HL73101-01A1 and R01 HL107910-01), Veterans Affairs Merit System
   0018 (J.R. Sowers).
CR Abbott NJ, 2006, NAT REV NEUROSCI, V7, P41, DOI 10.1038/nrn1824
   Akter K, 2011, BRIT J CLIN PHARMACO, V71, P365, DOI 10.1111/j.1365-2125.2010.03830.x
   [Anonymous], CLIN GERIATR
   Armulik A, 2010, NATURE, V468, P557, DOI 10.1038/nature09522
   Banks WA, 1998, PEPTIDES, V19, P883, DOI 10.1016/S0196-9781(98)00018-7
   Banks WA, 2012, ANN NY ACAD SCI, V1264, P13, DOI 10.1111/j.1749-6632.2012.06568.x
   Bell RD, 2010, NEURON, V68, P409, DOI 10.1016/j.neuron.2010.09.043
   Bell RD, 2009, ACTA NEUROPATHOL, V118, P103, DOI 10.1007/s00401-009-0522-3
   Biessels GJ, 2006, LANCET NEUROL, V5, P64, DOI 10.1016/S1474-4422(05)70284-2
   Bomboi G, 2010, NEUROL SCI, V31, P1, DOI 10.1007/s10072-009-0151-6
   Bowler JV, 1997, ARCH NEUROL-CHICAGO, V54, P697, DOI 10.1001/archneur.1997.00550180021007
   Carvalho C, 2012, DIABETES, V61, P1234, DOI 10.2337/db11-1186
   Cheng KC, 2012, BMC NEPHROL, V13, DOI 10.1186/1471-2369-13-129
   Coleman ES, 2010, BRAIN RES, V1306, P131, DOI 10.1016/j.brainres.2009.10.005
   Craft S, 2012, ARCH NEUROL-CHICAGO, V69, P29, DOI 10.1001/archneurol.2011.233
   Craft S, 2009, ARCH NEUROL-CHICAGO, V66, P300, DOI 10.1001/archneurol.2009.27
   Cui JK, 2012, MOL NEURODEGENER, V7, DOI 10.1186/1750-1326-7-21
   Cukierman T, 2005, DIABETOLOGIA, V48, P2460, DOI 10.1007/s00125-005-0023-4
   Daneman R, 2010, NATURE, V468, P562, DOI 10.1038/nature09513
   FRASER CL, 1988, ANN INTERN MED, V109, P143, DOI 10.7326/0003-4819-109-2-143
   Genuth S, 2007, NEW ENGL J MED, V356, P1842
   Girouard H, 2006, ARTERIOSCL THROM VAS, V26, P826, DOI 10.1161/01.ATV.0000205849.22807.6e
   Graham NL, 2004, J NEUROL NEUROSUR PS, V75, P61
   Hawkins BT, 2005, PHARMACOL REV, V57, P173, DOI 10.1124/pr.57.2.4
   Hayden MR, 2007, EXP BIOL MED, V232, P772
   Hayden MR, 2005, J PANCREAS, V6, P287
   Hayden MR, 2005, CARDIOVASC DIABETOL, V4, DOI 10.1186/1475-2840-4-4
   Hayden MR, 2010, OXID MED CELL LONGEV, V3, P290, DOI 10.4161/oxim.3.5.13653
   Jackson K., 2013, Annals of neurology
   Jefferson AL, 2010, J ALZHEIMERS DIS, V20, P813, DOI 10.3233/JAD-2010-100081
   Kappe C, 2012, J NEUROINFLAMM, V9, DOI 10.1186/1742-2094-9-276
   Kehoe PG, 2012, J ALZHEIMERS DIS, V30, pS251, DOI 10.3233/JAD-2012-111376
   Kodl CT, 2008, ENDOCR REV, V29, P494, DOI 10.1210/er.2007-0034
   Koehler RC, 2009, TRENDS NEUROSCI, V32, P160, DOI 10.1016/j.tins.2008.11.005
   Lanctot Krista L, 2009, Ther Adv Neurol Disord, V2, P163, DOI 10.1177/1756285609102724
   Lange S, 2013, DRUG DISCOV TODAY, V18, P456, DOI 10.1016/j.drudis.2012.12.007
   Li NC, 2010, BMJ-BRIT MED J, V340, DOI 10.1136/bmj.b5465
   Lin CH, 2013, J INTERN MED, V273, P102, DOI 10.1111/joim.12000
   Luchsinger JA, 2009, J ALZHEIMERS DIS, V16, P693, DOI 10.3233/JAD-2009-1022
   Lue Lih-Fen, 2012, Int J Alzheimers Dis, V2012, P918680, DOI 10.1155/2012/918680
   Manrique C, 2013, ENDOCRINOLOGY, V154, P3632, DOI 10.1210/en.2013-1256
   Mathias JL, 2009, NEUROPSYCHOLOGY, V23, P411, DOI 10.1037/a0015384
   McCrimmon RJ, 2012, LANCET, V379, P2291, DOI 10.1016/S0140-6736(12)60360-2
   McKinley MJ, 2003, INT J BIOCHEM CELL B, V35, P901, DOI 10.1016/S1357-2725(02)00306-0
   Mogi M, 2012, INT J HYPERTENS, V2012, DOI 10.1155/2012/169649
   Moreira PI, 2009, CNS NEUROL DISORD-DR, V8, P492, DOI 10.2174/187152709789824651
   Novak V, 2011, DIABETES CARE, V34, P2438, DOI 10.2337/dc11-0969
   Ott A, 1999, NEUROLOGY, V53, P1937, DOI 10.1212/WNL.53.9.1937
   Paul G, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035577
   Price TO, 2012, ENDOCRINOLOGY, V153, P362, DOI 10.1210/en.2011-1638
   Saijo K, 2011, NAT REV IMMUNOL, V11, P775, DOI 10.1038/nri3086
   Shah GN, 2013, J PHARMACOL EXP THER, V344, P637, DOI 10.1124/jpet.112.201400
   Sila Cathy A, 2007, Cleve Clin J Med, V74 Suppl 1, pS132
   Sofroniew MV, 2010, ACTA NEUROPATHOL, V119, P7, DOI 10.1007/s00401-009-0619-8
   Sowers JR, 2011, CARDIORENAL MED, V1, P5, DOI 10.1159/000322822
   Sowers KM, 2010, OXID MED CELL LONGEV, V3, P109, DOI 10.4161/oxim.3.2.11354
   Strachan MWJ, 2008, BRIT MED BULL, V88, P131, DOI 10.1093/bmb/ldn042
   Streit WJ, 2012, FRONT PHARMACOL, V3, DOI 10.3389/fphar.2012.00138
   Tamura MK, 2008, AM J KIDNEY DIS, V52, P227, DOI 10.1053/j.ajkd.2008.05.004
   Trevaskis JL, 2008, ENDOCRINOLOGY, V149, P5679, DOI 10.1210/en.2008-0770
   Vogels RLC, 2007, EUR J HEART FAIL, V9, P440, DOI 10.1016/j.ejheart.2006.11.001
   Vrang N, 2007, BRAIN RES, V1149, P118, DOI 10.1016/j.brainres.2007.02.043
   Wright JW, 2013, PFLUG ARCH EUR J PHY, V465, P133, DOI 10.1007/s00424-012-1102-2
   Wright JW, 2011, PROG NEUROBIOL, V95, P49, DOI 10.1016/j.pneurobio.2011.07.001
   Zhang M, 2010, NEUROSCIENCE, V171, P852, DOI 10.1016/j.neuroscience.2010.09.029
NR 65
TC 16
Z9 16
U1 0
U2 9
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1664-3828
EI 1664-5502
J9 CARDIORENAL MED
JI CardioRenal Med.
PY 2013
VL 3
IS 4
BP 265
EP 282
DI 10.1159/000357113
PG 18
WC Cardiac & Cardiovascular Systems; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Urology & Nephrology
GA 278UL
UT WOS:000328915300007
PM 24474955
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Johnson, RJ
   Perez-Pozo, SE
   Lillo, JL
   Grases, F
   Schold, JD
   Kuwabara, M
   Sato, Y
   Hernando, AA
   Garcia, G
   Jensen, T
   Rivard, C
   Sanchez-Lozada, LG
   Roncal, C
   Lanaspa, MA
AF Johnson, Richard J.
   Perez-Pozo, Santos E.
   Lillo, Julian Lopez
   Grases, Felix
   Schold, Jesse D.
   Kuwabara, Masanari
   Sato, Yuka
   Hernando, Ana Andres
   Garcia, Gabriela
   Jensen, Thomas
   Rivard, Christopher
   Sanchez-Lozada, Laura G.
   Roncal, Carlos
   Lanaspa, Miguel A.
TI Fructose increases risk for kidney stones: potential role in metabolic
   syndrome and heat stress
SO BMC NEPHROLOGY
LA English
DT Article
DE Fructose; Sugar; Sucrose; Kidney stone; Magnesium; Uric acid; Citrate;
   Oxalate
ID URINARY URIC-ACID; UNITED-STATES; INDUCED HYPERURICEMIA; SUGARCANE
   HARVESTERS; ORAL FRUCTOSE; RENAL INJURY; NEPHROLITHIASIS; OXALATE;
   DISEASE; PREVALENCE
AB BackgroundFructose intake, mainly as table sugar or high fructose corn syrup, has increased in recent decades and is associated with increased risk for kidney stones. We hypothesized that fructose intake alters serum and urinary components involved in stone formation.MethodsWe analyzed a previously published randomized controlled study that included 33 healthy male adults (40-65years of age) who ingested 200g of fructose (supplied in a 2-L volume of 10% fructose in water) daily for 2weeks. Participants were evaluated at the Unit of Nephrology of the Mateo Orfila Hospital in Menorca. Changes in serum levels of magnesium, calcium, uric acid, phosphorus, vitamin D, and intact PTH levels were evaluated. Urine magnesium, calcium, uric acid, phosphorus, citrate, oxalate, sodium, potassium, as well as urinary pH, were measured.ResultsIngestion of fructose was associated with an increased serum level of uric acid (p<0.001), a decrease in serum ionized calcium (p=0.003) with a mild increase in PTH (p<0.05) and a drop in urinary pH (p=0.02), an increase in urine oxalate (p=0.016) and decrease in urinary magnesium (p=0.003).ConclusionsFructose appears to increase urinary stone formation in part via effects on urate metabolism and urinary pH, and also via effects on oxalate. Fructose may be a contributing factor for the development of kidney stones in subjects with metabolic syndrome and those suffering from heat stress.Trial registrationClinicalTrials.gov NCT00639756 March 20, 2008.
C1 [Johnson, Richard J.; Kuwabara, Masanari; Sato, Yuka; Hernando, Ana Andres; Garcia, Gabriela; Jensen, Thomas; Rivard, Christopher; Roncal, Carlos; Lanaspa, Miguel A.] Univ Colorado, Div Renal Dis & Hypertens, Denver, CO 80202 USA.
   [Johnson, Richard J.] Eastern Colorado Hlth Care Syst, Dept Vet Affairs, Denver, CO 80220 USA.
   [Perez-Pozo, Santos E.] Clin San Felipe, Div Nephrol, Lima, Peru.
   [Lillo, Julian Lopez] Hosp Mateu Orfila, Menorca, Spain.
   [Grases, Felix] Univ Balearic Isl, IUNICS Idisba, Palma De Mallorca, Spain.
   [Schold, Jesse D.] Cleveland Clin Fdn, Dept Quantitat Hlth Sci, 9500 Euclid Ave, Cleveland, OH 44195 USA.
   [Sanchez-Lozada, Laura G.] Inst Nacl Cardiol, Lab Renal Physiopathol, Mexico City, DF, Mexico.
   [Johnson, Richard J.] Univ Colorado, Div Renal Dis, Anschutz Med Campus, Aurora, CO 80045 USA.
C3 University of Colorado System; University of Colorado Denver; Hospital
   Mateu Orfila; Universitat de les Illes Balears; Institut Investigacio
   Sanitaria Illes Balears (IdISBa); Cleveland Clinic Foundation; National
   Institute of Cardiology - Mexico; University of Colorado System;
   University of Colorado Anschutz Medical Campus
RP Johnson, RJ (corresponding author), Univ Colorado, Div Renal Dis & Hypertens, Denver, CO 80202 USA.; Johnson, RJ (corresponding author), Eastern Colorado Hlth Care Syst, Dept Vet Affairs, Denver, CO 80220 USA.
EM richard.johnson@ucdenver.edu
RI Lanaspa, Miguel/AAO-4971-2020; Schold, Jesse/AAC-5844-2019;
   Sanchez-Lozada, Laura/AAS-2104-2021; Kuwabara, Masanari/O-9844-2017
OI Johnson, Richard/0000-0003-3312-8193; Kuwabara,
   Masanari/0000-0002-6601-4347; Sanchez-Lozada,
   Laura-Gabriela/0000-0003-0348-9617; Andres-Hernando,
   Ana/0000-0002-0676-0188
FU Mateu Orfila Fundation; Institute for Research in Health Sciences
   (IUNICS) at the University of the Balearic Islands (Palma de Mallorca,
   Spain)
FX This work was supported by the Mateu Orfila Fundation and the Institute
   for Research in Health Sciences (IUNICS) at the University of the
   Balearic Islands (Palma de Mallorca, Spain).
CR Asselman M, 2008, KIDNEY INT, V73, P139, DOI 10.1038/sj.ki.5002700
   Bawden SJ, 2016, CLIN NUTR, V35, P645, DOI 10.1016/j.clnu.2015.04.001
   BORGHI L, 1993, J UROLOGY, V150, P1757, DOI 10.1016/S0022-5347(17)35887-1
   Borghi L, 1996, J UROLOGY, V155, P839, DOI 10.1016/S0022-5347(01)66321-3
   Brikowski TH, 2008, P NATL ACAD SCI USA, V105, P9841, DOI 10.1073/pnas.0709652105
   CAPPUCCIO FP, 1990, BMJ-BRIT MED J, V300, P1234, DOI 10.1136/bmj.300.6734.1234
   Cappuccio FP, 1999, J HYPERTENS, V17, P1017, DOI 10.1097/00004872-199917070-00019
   Chen W, 2014, METABOLISM, V63, P150, DOI 10.1016/j.metabol.2013.09.018
   Cho S, 2013, APPL ECON LETT, V20, P208, DOI 10.1080/13504851.2012.689100
   Choi HK, 2008, BMJ-BRIT MED J, V336, P309, DOI 10.1136/bmj.39449.819271.BE
   Choi Hyon K., 2010, JAMA (Journal of the American Medical Association), V304, P2270, DOI 10.1001/jama.2010.1638
   Choi JWJ, 2008, ARTHRIT RHEUM-ARTHR, V59, P109, DOI 10.1002/art.23245
   CLIFFORD AJ, 1976, J NUTR, V106, P428, DOI 10.1093/jn/106.3.428
   Cox CL, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-68
   Crowe J, 2015, AM J IND MED, V58, P541, DOI 10.1002/ajim.22450
   Crowe J, 2013, AM J IND MED, V56, P1157, DOI 10.1002/ajim.22204
   Curhan GC, 2004, ARCH INTERN MED, V164, P885, DOI 10.1001/archinte.164.8.885
   Daudon M, 2006, J AM SOC NEPHROL, V17, P2026, DOI 10.1681/ASN.2006030262
   Daudon M, 2006, UROL RES, V34, P193, DOI 10.1007/s00240-006-0042-8
   De SK, 2014, UROLOGY, V84, P1030, DOI 10.1016/j.urology.2014.06.037
   Douard V, 2010, J AM SOC NEPHROL, V21, P261, DOI 10.1681/ASN.2009080795
   Ekeruo WO, 2004, J UROLOGY, V172, P159, DOI 10.1097/01.ju.0000128574.50588.97
   Fakheri RJ, 2009, KIDNEY INT, V76, P798, DOI 10.1038/ki.2009.274
   Ferraro PM, 2013, CLIN J AM SOC NEPHRO, V8, P1389, DOI 10.2215/CJN.11661112
   Fischer EM, 2015, NAT CLIM CHANGE, V5, P560, DOI 10.1038/nclimate2617
   FOX IH, 1972, METABOLISM, V21, P713, DOI 10.1016/0026-0495(72)90120-5
   García-Arroyo FE, 2017, INT J BIOL SCI, V13, P961, DOI 10.7150/ijbs.20074
   García-Arroyo FE, 2016, AM J PHYSIOL-REG I, V311, pR57, DOI 10.1152/ajpregu.00354.2015
   Glaser J, 2016, CLIN J AM SOC NEPHRO, V11, P1472, DOI 10.2215/CJN.13841215
   HAMM LL, 1990, KIDNEY INT, V38, P728, DOI 10.1038/ki.1990.265
   Holmes RP, 1998, J UROLOGY, V160, P1617, DOI 10.1016/S0022-5347(01)62363-2
   Jimenez CAR, 2014, KIDNEY INT, V86, P294, DOI 10.1038/ki.2013.492
   Johnson RJ, 2013, DIABETES, V62, P3307, DOI 10.2337/db12-1814
   Johnson RJ, 2013, NEPHROL DIAL TRANSPL, V28, P2221, DOI 10.1093/ndt/gft029
   Johnson RJ, 2009, ENDOCR REV, V30, P96, DOI 10.1210/er.2008-0033
   KNOCHEL JP, 1974, ANN INTERN MED, V81, P321, DOI 10.7326/0003-4819-81-3-321
   KOK DJ, 1988, KIDNEY INT, V34, P346, DOI 10.1038/ki.1988.187
   Kummu M, 2010, ENVIRON RES LETT, V5, DOI 10.1088/1748-9326/5/3/034006
   Kuwabara M, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0169137
   Le MT, 2012, METABOLISM, V61, P641, DOI 10.1016/j.metabol.2011.09.013
   Lotan Y, 2012, BJU INT, V110, pE1060, DOI 10.1111/j.1464-410X.2012.11212.x
   Maalouf NM, 2007, CLIN J AM SOC NEPHRO, V2, P883, DOI 10.2215/CJN.00670207
   Maalouf NM, 2011, J RENAL NUTR, V21, P128, DOI 10.1053/j.jrn.2010.10.015
   Matthews TKR, 2017, P NATL ACAD SCI USA, V114, P3861, DOI 10.1073/pnas.1617526114
   Melnick JZ, 1996, J CLIN INVEST, V98, P2381, DOI 10.1172/JCI119051
   Nakanishi N, 2012, KIDNEY BLOOD PRESS R, V35, P77, DOI 10.1159/000330487
   Nakayama T, 2010, AM J PHYSIOL-RENAL, V298, pF712, DOI 10.1152/ajprenal.00433.2009
   NGUYEN NU, 1989, HORM METAB RES, V21, P96, DOI 10.1055/s-2007-1009160
   NGUYEN NU, 1995, HORM METAB RES, V27, P155, DOI 10.1055/s-2007-979929
   Ogawa S, 2015, CLIN EXP NEPHROL, V19, P822, DOI 10.1007/s10157-014-1066-y
   Perez-Pozo SE, 2010, INT J OBESITY, V34, P454, DOI 10.1038/ijo.2009.259
   Perez-Ruiz F, 2002, ARTHRIT RHEUM-ARTHR, V47, P610, DOI 10.1002/art.10792
   PERHEENT.J, 1967, LANCET, V2, P528
   Rahmstorf S, 2011, P NATL ACAD SCI USA, V108, P17905, DOI 10.1073/pnas.1101766108
   ROFE AM, 1986, BIOCHEM MED METAB B, V36, P141, DOI 10.1016/0885-4505(86)90118-0
   Roncal-Jimenez C, 2016, AM J KIDNEY DIS, V67, P20, DOI 10.1053/j.ajkd.2015.08.021
   Roncal-Jimenez CA, 2017, AM J PHYSIOL-RENAL, V312, pF418, DOI 10.1152/ajprenal.00495.2016
   Shang WF, 2017, PEERJ, V5, DOI 10.7717/peerj.2907
   Shoag J, 2014, J UROLOGY, V192, P1440, DOI 10.1016/j.juro.2014.05.117
   Shoham DA, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003431
   SHUSTER J, 1992, J CLIN EPIDEMIOL, V45, P911, DOI 10.1016/0895-4356(92)90074-W
   Song ZL, 2017, J NEUROPHYSIOL, V117, P646, DOI 10.1152/jn.00781.2016
   Sontrop JM, 2013, AM J NEPHROL, V37, P434, DOI 10.1159/000350377
   SPENCE JT, 1982, EUR J BIOCHEM, V128, P15
   Stamatelou KK, 2003, KIDNEY INT, V63, P1817, DOI 10.1046/j.1523-1755.2003.00917.x
   STIRPE F, 1970, LANCET, V2, P1310
   Sun SZ, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-89
   Taylor EN, 2008, KIDNEY INT, V73, P207, DOI 10.1038/sj.ki.5002588
   WOLF JP, 1992, HORM METAB RES, V24, P379, DOI 10.1055/s-2007-1003340
   Wollin DA, 2017, CURR OPIN UROL, V27, P422, DOI 10.1097/MOU.0000000000000427
   Wong YV, 2015, INT J ENDOCRINOL, V2015, DOI 10.1155/2015/570674
   Zimmermann DJ, 2005, UROL INT, V74, P262, DOI 10.1159/000083560
NR 72
TC 43
Z9 47
U1 0
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2369
J9 BMC NEPHROL
JI BMC Nephrol.
PD NOV 8
PY 2018
VL 19
AR 315
DI 10.1186/s12882-018-1105-0
PG 7
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA GZ9XL
UT WOS:000449856000005
PM 30409184
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Aneni, EC
   Oni, ET
   Osondu, CU
   Martin, SS
   Blaha, MJ
   Veledar, E
   Agatston, AS
   Feldman, T
   Carvalho, JAM
   Conceiçao, RD
   Santos, RD
   Nasir, K
AF Aneni, Ehimen C.
   Oni, Ebenezer T.
   Osondu, Chukwuemeka U.
   Martin, Seth S.
   Blaha, Michael J.
   Veledar, Emir
   Agatston, Arthur S.
   Feldman, Theodore
   Carvalho, Jose A. M.
   Conceicao, Raquel D.
   Santos, Raul D.
   Nasir, Khurram
TI Obesity Modifies the Effect of Fitness on Heart Rate Indices during
   Exercise Stress Testing in Asymptomatic Individuals
SO CARDIOLOGY
LA English
DT Article
DE Fitness; Obesity; Body mass index; Heart rate; Stress test; Metabolic
   equivalents
ID ALL-CAUSE MORTALITY; RATE RECOVERY; CARDIORESPIRATORY FITNESS;
   CARDIOMETABOLIC RISK; PHYSICAL-ACTIVITY; RATE RESPONSE; PREDICTOR;
   HEALTHY; ASSOCIATION; CONSUMPTION
AB Objective: To assess the impact of aerobic fitness on exercise heart rate (HR) indices in an asymptomatic cohort across different body mass index (BMI) categories. Methods: We performed a cross-sectional analysis of 506 working-class Brazilian subjects, free of known clinical cardiovascular disease (e.g. ischemic heart disease and stroke) who underwent an exercise stress test. Results: There was a significant trend towards decreased HR at peak exercise, HR recovery and chronotropic index (CI) measures as BMI increased, but resting HR increased significantly across BMI categories. In multivariate analysis, the change in CI per unit change in metabolic equivalents of task was greater among the obese subjects than the normal-weight (2.7 vs. -0.07; p interaction = 0.029) and overweight (2.7 vs. 0.7; p interaction = 0.044) subjects. A similar pattern was seen with peak HR and HR recovery, although the formal tests of interaction did not achieve statistical significance. Conclusion: Our findings strongly suggest that fitness is associated with a favorable HR profile and is modified by BMI. Intervention programs should place emphasis on fitness and not only on weight loss. (C) 2015 S. Karger AG, Basel
C1 [Aneni, Ehimen C.; Osondu, Chukwuemeka U.; Veledar, Emir; Agatston, Arthur S.; Feldman, Theodore; Nasir, Khurram] Baptist Hlth South Florida, Ctr Healthcare Adv & Outcomes, Miami, FL USA.
   Mt Sinai Med Ctr, Miami Beach, FL 33140 USA.
   [Veledar, Emir; Nasir, Khurram] Florida Int Univ, Robert Stempel Coll Publ Hlth, Miami, FL 33199 USA.
   [Nasir, Khurram] Florida Int Univ, Herbert Wertheim Coll Med, Miami, FL 33199 USA.
   [Oni, Ebenezer T.] Brooklyn Hosp, Brooklyn, NY USA.
   [Martin, Seth S.; Blaha, Michael J.; Nasir, Khurram] Johns Hopkins Ciccarone Ctr Prevent Cardiovasc Di, Baltimore, MD USA.
   [Veledar, Emir] Emory Univ, Sch Med, Dept Med, Atlanta, GA USA.
   [Carvalho, Jose A. M.; Conceicao, Raquel D.; Santos, Raul D.] Univ Sao Paulo, Med Sch Hosp, Hosp Israelita Albert Einstein, Sao Paulo, Brazil.
   [Carvalho, Jose A. M.; Conceicao, Raquel D.; Santos, Raul D.] Univ Sao Paulo, Med Sch Hosp, Heart Inst InCor, Sao Paulo, Brazil.
   [Nasir, Khurram] Baptist Hlth South Florida, Miami Cardiac & Vasc Inst, Miami, FL USA.
C3 Mount Sinai Medical Center; State University System of Florida; Florida
   International University; State University System of Florida; Florida
   International University; Brooklyn Hospital Center; Johns Hopkins
   University; Johns Hopkins Medicine; Emory University; Universidade de
   Sao Paulo; Hospital Israelita Albert Einstein; Universidade de Sao
   Paulo; Baptist Cardiac & Vascular Institute
RP Aneni, EC (corresponding author), 1500 San Remo Ave,Suite 350, Miami, FL 33146 USA.
EM ehimena@baptisthealth.net
RI Veledar, Emir/L-6637-2019; Nasir, Khurram/A-2317-2008; Santos,
   Raul/A-1170-2010; Osondu, Chukwuemeka/JXY-7302-2024
OI Veledar, Emir/0000-0002-3831-5433; Martin, Seth/0000-0002-7021-7622
CR ARAI Y, 1989, AM J PHYSIOL, V256, pH132, DOI 10.1152/ajpheart.1989.256.1.H132
   Barry VW, 2014, PROG CARDIOVASC DIS, V56, P382, DOI 10.1016/j.pcad.2013.09.002
   BRUCE RA, 1973, AM HEART J, V85, P546, DOI 10.1016/0002-8703(73)90502-4
   Campos EZ, 2012, INT J SPORTS MED, V33, P621, DOI 10.1055/s-0031-1295442
   Ciolac EG, 2011, CLINICS, V66, P583, DOI 10.1590/S1807-59322011000400011
   Cole CR, 2000, ANN INTERN MED, V132, P552, DOI 10.7326/0003-4819-132-7-200004040-00007
   Cole CR, 1999, NEW ENGL J MED, V341, P1351, DOI 10.1056/NEJM199910283411804
   Cooney MT, 2010, AM HEART J, V159, P612, DOI 10.1016/j.ahj.2009.12.029
   Dimkpa U, 2010, EUR J APPL PHYSIOL, V108, P695, DOI 10.1007/s00421-009-1276-2
   Fogelholm M, 2010, OBES REV, V11, P202, DOI 10.1111/j.1467-789X.2009.00653.x
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   García-López M, 2014, EUR J PREV CARDIOL, V21, P521, DOI 10.1177/2047487312467871
   Go AS, 2014, CIRCULATION, V129, pE28, DOI 10.1161/01.cir.0000441139.02102.80
   Gondoni LA, 2009, NUTR METAB CARDIOVAS, V19, P170, DOI 10.1016/j.numecd.2008.07.001
   Gulati M, 2010, CIRCULATION, V122, P130, DOI 10.1161/CIRCULATIONAHA.110.939249
   Hansen AL, 2014, J CLIN SLEEP MED, V10, P567, DOI 10.5664/jcsm.3714
   IMAI K, 1994, J AM COLL CARDIOL, V24, P1529, DOI 10.1016/0735-1097(94)90150-3
   Jensen MT, 2013, HEART, V99, P882, DOI 10.1136/heartjnl-2012-303375
   JETTE M, 1990, CLIN CARDIOL, V13, P555, DOI 10.1002/clc.4960130809
   Jouven X, 2005, NEW ENGL J MED, V352, P1951, DOI 10.1056/NEJMoa043012
   Laguna M, 2013, NUTR METAB CARDIOVAS, V23, P995, DOI 10.1016/j.numecd.2012.10.002
   Lauer M, 2005, CIRCULATION, V112, P771, DOI 10.1161/CIRCULATIONAHA.105.166543
   Lauer M S, 2001, Cardiol Clin, V19, P401
   Lauer MS, 1999, JAMA-J AM MED ASSOC, V281, P524, DOI 10.1001/jama.281.6.524
   McAuley PA, 2012, MAYO CLIN PROC, V87, P443, DOI 10.1016/j.mayocp.2012.01.013
   Nishime EO, 2000, JAMA-J AM MED ASSOC, V284, P1392, DOI 10.1001/jama.284.11.1392
   Pickering Thomas G., 2005, Hypertension (Baltimore), V45, P142
   Rogowski O, 2009, CARDIOVASC DIABETOL, V8, DOI 10.1186/1475-2840-8-55
   Rosenwinkel Eric T., 2001, Cardiology Clinics, V19, P369, DOI 10.1016/S0733-8651(05)70223-X
   Swift DL, 2014, PROG CARDIOVASC DIS, V56, P441, DOI 10.1016/j.pcad.2013.09.012
   Tentolouris N, 2006, ANN NY ACAD SCI, V1083, P129, DOI 10.1196/annals.1367.010
   Vranian MN, 2013, AM J CARDIOL, V111, P991, DOI 10.1016/j.amjcard.2012.12.022
NR 32
TC 3
Z9 6
U1 0
U2 16
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0008-6312
EI 1421-9751
J9 CARDIOLOGY
JI Cardiology
PY 2015
VL 132
IS 4
BP 242
EP 248
DI 10.1159/000435907
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CT7CM
UT WOS:000362970900006
PM 26329389
DA 2025-06-11
ER

PT J
AU Leite-Almeida, L
   Morato, M
   Cosme, D
   Afonso, J
   Areias, JC
   Guerra, A
   Afonso, AC
   Albino-Teixeira, A
   Sousa, T
   Correia-Costa, L
AF Leite-Almeida, Laura
   Morato, Manuela
   Cosme, Dina
   Afonso, Joana
   Areias, Jose C.
   Guerra, Antonio
   Afonso, Alberto Caldas
   Albino-Teixeira, Antonio
   Sousa, Teresa
   Correia-Costa, Liane
TI Impact of physical activity on redox status and nitric oxide
   bioavailability in nonoverweight and overweight/obese prepubertal
   children
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Childhood obesity; Oxidative stress; Nitric oxide; Antioxidant capacity;
   Cardiometabolic risk factors; Physical activity; Exercise
ID OXIDATIVE STRESS; CARDIOVASCULAR RISK; INSULIN-RESISTANCE; OBESE
   CHILDREN; RENAL-FUNCTION; NORMAL-WEIGHT; EXERCISE; ASSOCIATION;
   DYSFUNCTION; FITNESS
AB Nutritional status might contribute to variations induced by physical activity (PA) in redox status biomarkers. We investigated the influence of PA on redox status and nitric oxide (NO) production/metabolism biomarkers in nonoverweight and overweight/obese prepubertal children. We performed a cross-sectional evaluation of 313 children aged 8-9 years (163 nonoverweight, 150 overweight/obese) followed since birth in a cohort study (Generation XXI, Porto, Portugal). Plasma total antioxidant status (P-TAS), plasma and urinary isoprostanes (P-Isop, U-Isop), urinary hydrogen peroxide (U-H2O2), myeloperoxidase (MPO) and plasma and urinary nitrates and nitrites (P-NOx, U-NOx) were assessed, as well as their association with variables of reported PA quantification (categories of PA frequency (>1x/week and <= 1x/week)and continuous PA index (obtained by the sum of points)) in a questionnaire with increasing ranks from sedentary to vigorous activity levels. U-NOx was significantly higher in children who presented higher PA index scores and higher PA frequency. Separately by BMI classes, U-NOx was significantly higher only in nonoverweight children who practiced PA more frequently (p = 0.037). In overweight/obese children, but not in nonoverweight, P-TAS was higher among children with higher PA frequency (p = 0.007). Homeostasis model assessment index (HOMA-IR) was significantly lower in more active overweight/obese children, but no differences were observed in nonoverweight children. In the fully adjusted multivariate linear regression models for P-TAS, in the overweight/obese group, children with higher PA frequency presented higher P-TAS. In the U-NOx models, U-NOx significantly increased with PA index, only in nonoverweight children. Our results provide additional evidence in support of a protective effect of physical activity, in nonoverweight by increasing NO bioavailability and in overweight/obese children by enhancing systemic antioxidant capacity and insulin sensitivity. These results highlight the importance of engaging in regular physical exercise, particularly among overweight/obese children, in which a positive association between oxidant status and cardiometabolic risk markers has been described.
C1 [Leite-Almeida, Laura; Afonso, Alberto Caldas; Correia-Costa, Liane] Univ Porto, Inst Ciencias Biomed Abel Salazar, Porto, Portugal.
   [Morato, Manuela] Univ Porto, Fac Pharm Porto, Dept Drug Sci, Lab Pharmacol, Porto, Portugal.
   [Morato, Manuela] Univ Porto, Fac Pharm Porto, LAQV REQUIMTE, Porto, Portugal.
   [Cosme, Dina; Afonso, Joana; Albino-Teixeira, Antonio; Sousa, Teresa] Univ Porto, Dept Biomed, Unit Pharmacol & Therapeut, Fac Med, Porto, Portugal.
   [Cosme, Dina; Afonso, Joana; Albino-Teixeira, Antonio; Sousa, Teresa] Univ Porto, MedInUP Ctr Drug Discovery & Innovat Med, Porto, Portugal.
   [Areias, Jose C.; Guerra, Antonio] Univ Porto, Dept Gynecol Obstet & Pediat, Fac Med, Porto, Portugal.
   [Areias, Jose C.] Ctr Hosp Univ Sao Joao, Integrated Pediat Hosp, Div Pediat Cardiol, Porto, Portugal.
   [Guerra, Antonio] Ctr Hosp Univ Sao Joao, Integrated Pediat Hosp, Div Pediat Nutr, Porto, Portugal.
   [Afonso, Alberto Caldas; Correia-Costa, Liane] Univ Porto, EPIUnit Inst Saude Publ, Porto, Portugal.
   [Afonso, Alberto Caldas; Correia-Costa, Liane] Ctr Hosp Univ Porto, Ctr Maternoinfantil Norte, Dept Pediat Nephrol, Porto, Portugal.
C3 Universidade do Porto; Universidade do Porto; Universidade do Porto;
   Universidade do Porto; Universidade do Porto; Universidade do Porto;
   Universidade do Porto; Universidade do Porto
RP Correia-Costa, L (corresponding author), Inst Sande Publ Univ Porto ISPUP, Rua Taipas 135, P-4050600 Porto, Portugal.
EM lianecosta@icbas.up.pt
RI Afonso, Carlos/M-7833-2013; , Teresa/HSF-0698-2023; Morato,
   Manuela/D-7563-2013; Correia-Costa, Liane/JPA-4135-2023;
   Albino-Teixeira, Antonio/HPI-0713-2023
OI Morato, Manuela/0000-0002-9509-0613; Correia-Costa,
   Liane/0000-0002-8216-090X; Albino-Teixeira, Antonio/0000-0003-0097-2953;
   Sousa, Teresa/0000-0001-7230-5020; Cosme, Dina/0000-0002-8398-0184;
   Leite-Almeida, Laura/0000-0003-2319-1332
FU FEDER funds from Programa Operacional Factores de Competitividade -
   COMPETE [FCOMP-01-0124-FEDER-028751]; Portuguese Foundation for Science
   and Technology (FCT), Lisbon, Portugal [PTDC/DTP-PIC/0239/2012];
   Calouste Gulbenkian Foundation; FCT [SFRH/SINTD/95898/2013]; FCT;
   POPH/FSE (EC) [SFRH/BPD/112005]; POPH/FSE (EC) [Ciencia 2008]; Fundação
   para a Ciência e a Tecnologia [PTDC/DTP-PIC/0239/2012] Funding Source:
   FCT
FX This project was supported by FEDER funds from Programa Operacional
   Factores de Competitividade - COMPETE [FCOMP-01-0124-FEDER-028751], by
   national funds from the Portuguese Foundation for Science and Technology
   (FCT), Lisbon, Portugal [PTDC/DTP-PIC/0239/2012] and by Calouste
   Gulbenkian Foundation. Liane CorreiaCosta was supported by FCT
   [SFRH/SINTD/95898/2013] and Teresa Sousa was supported by FCT and
   POPH/FSE (EC) [Ciencia 2008 and SFRH/BPD/112005].
CR Abudukadier A, 2013, DIABETES, V62, P3033, DOI 10.2337/db12-1242
   Ahmad A, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19092605
   Aires L, 2012, INT J SPORTS MED, V33, P325, DOI 10.1055/s-0031-1297955
   Avloniti A, 2017, ANTIOXIDANTS-BASEL, V6, DOI 10.3390/antiox6010006
   Börgeson E, 2015, CELL METAB, V22, P125, DOI 10.1016/j.cmet.2015.05.003
   Bruder-Nascimento T, 2015, BRAZ J PHYS THER, V19, P177, DOI 10.1590/bjpt-rbf.2014.0088
   Cai H, 2000, CIRC RES, V87, P840, DOI 10.1161/01.RES.87.10.840
   Cakmak A, 2010, PEDIATR EXERC SCI, V22, P93, DOI 10.1123/pes.22.1.93
   Carlsohn A, 2010, MED SCI SPORT EXER, V42, P1131, DOI 10.1249/MSS.0b013e3181c74f7b
   Casey DP, 2017, AM J PHYSIOL-HEART C, V313, pH854, DOI 10.1152/ajpheart.00282.2017
   Clarkson PM, 2000, AM J CLIN NUTR, V72, p637S, DOI 10.1093/ajcn/72.2.637S
   Codoñer-Franch P, 2011, ATHEROSCLEROSIS, V215, P475, DOI 10.1016/j.atherosclerosis.2010.12.035
   Correia-Costa L, 2016, BRIT J NUTR, V116, P805, DOI 10.1017/S0007114516002804
   Correia-Costa L, 2016, EUR J CLIN INVEST, V46, P50, DOI 10.1111/eci.12564
   Correia-Costa L, 2015, PEDIATR RES, V78, P436, DOI 10.1038/pr.2015.130
   Covas MI, 2002, MED SCI SPORT EXER, V34, P814, DOI 10.1097/00005768-200205000-00014
   de Onis M, 2007, B WORLD HEALTH ORGAN, V85, P660, DOI 10.2471/BLT.07.043497
   Dennis BA, 2013, CHILD OBES, V9, P15, DOI 10.1089/chi.2011.0092
   Dias KA, 2015, PEDIATRICS, V136, pE648, DOI 10.1542/peds.2015-0616
   Durao C, 2015, EUR J NUTR, V54, P835, DOI 10.1007/s00394-014-0762-4
   Fang FC, 2019, CURR OPIN IMMUNOL, V60, P96, DOI 10.1016/j.coi.2019.05.008
   Fedewa MV, 2014, PEDIATRICS, V133, pE163, DOI 10.1542/peds.2013-2718
   Finaud J, 2006, SPORTS MED, V36, P327, DOI 10.2165/00007256-200636040-00004
   Förstermann U, 2012, EUR HEART J, V33, P829, DOI 10.1093/eurheartj/ehr304
   Gabbai FB, 2001, NEPHROL DIAL TRANSPL, V16, P10, DOI 10.1093/ndt/16.suppl_1.10
   Gomez-Cabrera MC, 2008, FREE RADICAL BIO MED, V44, P126, DOI 10.1016/j.freeradbiomed.2007.02.001
   Gonenc Sevil, 2000, Indian Journal of Physiology and Pharmacology, V44, P340
   Gougoura S, 2007, EUR J APPL PHYSIOL, V100, P235, DOI 10.1007/s00421-007-0423-x
   Ho M, 2013, JAMA PEDIATR, V167, P759, DOI 10.1001/jamapediatrics.2013.1453
   Jones DP, 2008, AM J PHYSIOL-CELL PH, V295, pC849, DOI 10.1152/ajpcell.00283.2008
   Kabasakalis A, 2009, J SCI MED SPORT, V12, P691, DOI 10.1016/j.jsams.2008.05.005
   Kelishadi R, 2008, CLIN CHEM, V54, P147, DOI 10.1373/clinchem.2007.089953
   Kubota T, 2011, CELL METAB, V13, P294, DOI 10.1016/j.cmet.2011.01.018
   Larsen PS, 2013, PAEDIATR PERINAT EP, V27, P393, DOI 10.1111/ppe.12060
   Leal J, 2019, NITRIC OXIDE-BIOL CH, V82, P1, DOI 10.1016/j.niox.2018.10.007
   Ledent M., 1997, Sport, V159/160, P90
   Li HG, 2014, ATHEROSCLEROSIS, V237, P208, DOI 10.1016/j.atherosclerosis.2014.09.001
   Llorente-Cantarero FJ, 2012, FREE RADICAL BIO MED, V53, P415, DOI 10.1016/j.freeradbiomed.2012.05.017
   Manna P, 2015, METAB SYNDR RELAT D, V13, P423, DOI 10.1089/met.2015.0095
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McCormack SE, 2014, PEDIATR OBES, V9, P281, DOI 10.1111/j.2047-6310.2013.00180.x
   McIntosh N, 2000, Arch Dis Child, V82, P177
   Milne GL, 2015, BBA-MOL CELL BIOL L, V1851, P433, DOI 10.1016/j.bbalip.2014.10.007
   Miyazaki H, 2001, EUR J APPL PHYSIOL, V84, P1, DOI 10.1007/s004210000342
   Morato M, 2017, PEDIATR NEPHROL, V32, P1411, DOI 10.1007/s00467-017-3639-y
   Mota J, 2002, INT J BEHAV MED, V9, P111, DOI 10.1207/S15327558IJBM0902_03
   Niess AM, 2007, FRONT BIOSCI-LANDMRK, V12, P4826, DOI 10.2741/2431
   Pacher P, 2007, PHYSIOL REV, V87, P315, DOI 10.1152/physrev.00029.2006
   Paltoglou G, 2015, PEDIATR RES, V78, P158, DOI 10.1038/pr.2015.85
   RAITAKARI OT, 1994, AM J EPIDEMIOL, V140, P195, DOI 10.1093/oxfordjournals.aje.a117239
   Reina-Couto M, 2021, BIOMED PHARMACOTHER, V133, DOI 10.1016/j.biopha.2020.110938
   Remer T, 2002, AM J CLIN NUTR, V75, P561, DOI 10.1093/ajcn/75.3.561
   Rosa JS, 2011, PEDIATR DIABETES, V12, P464, DOI 10.1111/j.1399-5448.2010.00724.x
   Sansbury BE, 2014, FREE RADICAL BIO MED, V73, P383, DOI 10.1016/j.freeradbiomed.2014.05.016
   Santos-Silva A, 2001, CLIN CHIM ACTA, V306, P119, DOI 10.1016/S0009-8981(01)00406-5
   Schuler G, 2013, EUR HEART J, V34, P1790, DOI 10.1093/eurheartj/eht111
   Sieverdes JC, 2010, BRIT J SPORT MED, V44, P238, DOI 10.1136/bjsm.2009.062117
   Sousa T, 2012, BRIT J PHARMACOL, V166, P2386, DOI 10.1111/j.1476-5381.2012.01957.x
   Sousa T, 2012, LIPID PEROXIDATION, P345, DOI 10.5772/50346
   Stephen RC, HOWIE SAFE BLOOD SAM, DOI [10.2471/BLT.10.080010, DOI 10.2471/BLT.10.080010]
   Taylor NF, 2014, J PHYSIOTHER, V60, P179, DOI [10.1016/j.jphys.2014.06.013, 10.1016/j.jphys.2014.08.004]
   Tong TK, 2012, OXID MED CELL LONGEV, V2012, DOI 10.1155/2012/741239
   Vincent HK, 2009, METABOLISM, V58, P254, DOI 10.1016/j.metabol.2008.09.022
   Wing RR, 2007, MED SCI SPORT EXER, V39, P2107, DOI 10.1249/mss.0b013e31815614cb
   Yilmaz N., Int J Adolesc Med Health, V19, P177
   Zalavras A, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/283921
   Zivkovic V, 2013, ACTA PHYSIOL HUNG, V100, P64, DOI 10.1556/APhysiol.100.2013.1.6
NR 67
TC 9
Z9 9
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD FEB 1
PY 2021
VL 163
BP 116
EP 124
DI 10.1016/j.freeradbiomed.2020.12.005
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA PY6YT
UT WOS:000612189300003
PM 33309779
OA Green Published
DA 2025-06-11
ER

PT J
AU De Rosa, C
   Sampogna, G
   Luciano, M
   Del Vecchio, V
   Pocai, B
   Borriello, G
   Giallonardo, V
   Savorani, M
   Pinna, F
   Pompili, M
   Fiorillo, A
AF De Rosa, Corrado
   Sampogna, Gaia
   Luciano, Mario
   Del Vecchio, Valeria
   Pocai, Benedetta
   Borriello, Giuseppina
   Giallonardo, Vincenzo
   Savorani, Micaela
   Pinna, Federica
   Pompili, Maurizio
   Fiorillo, Andrea
TI Improving physical health of patients with severe mental disorders: a
   critical review of lifestyle psychosocial interventions
SO EXPERT REVIEW OF NEUROTHERAPEUTICS
LA English
DT Review
DE Severe mental illness; lifestyle behaviours; mortality rate; physical
   health; psychosocial intervention; schizophrenia; bipolar disorder;
   depression
ID RANDOMIZED CONTROLLED-TRIAL; MAJOR DEPRESSIVE DISORDER; BIPOLAR I
   DISORDER; PSYCHOEDUCATIONAL FAMILY INTERVENTION; CARDIOVASCULAR-DISEASE
   RISK; REDUCTION INTERVENTION; 1ST-EPISODE PSYCHOSIS; SEDENTARY BEHAVIOR;
   METABOLIC SYNDROME; SMOKING-CESSATION
AB Introduction: People with severe mental disorders have a mortality rate that is more than two times higher than the general population, with at least a decade of potential years of life lost. People with mental disorders have a significantly higher risk of obesity, hyperglycemia and metabolic syndrome, which are related to modifiable risk factors, such as heavy smoking, poor physical activities, and inappropriate unhealthy diet, which can be improved through lifestyle changes.Areas covered: Lifestyle behaviours are amenable to change through the adoption of specific psychosocial interventions, and several approaches have been promoted. In the present review, the authors aim to: 1) critically analyze studies involving multimodal lifestyle interventions; 2) discuss the way forward to integrate these interventions in clinical routine care.Expert commentary: The psychoeducational approaches developed for the improvement of healthy lifestyle behaviours differ for several aspects: 1) the format (individual vs. group); 2) the setting (outpatient vs. inpatient vs. home-based); 3) the professional characteristics of the staff running the intervention (psychiatrists or nurses or dietitians or psychologists); 4) the active ingredients of the intervention (education only or inclusion of motivational interview or of problem solving); 5) the duration of treatment (ranging from 3months to 2years).
C1 [De Rosa, Corrado; Sampogna, Gaia; Luciano, Mario; Del Vecchio, Valeria; Pocai, Benedetta; Borriello, Giuseppina; Giallonardo, Vincenzo; Savorani, Micaela; Fiorillo, Andrea] Univ Naples SUN, Dept Psychiat, Naples, Italy.
   [Pinna, Federica] Univ Cagliari, Sect Psychiat, Dept Publ Hlth Clin & Mol Med, Cagliari, Italy.
   [Pompili, Maurizio] Sapienza Univ Rome, Suicide Prevent Ctr, Dept Neurosci Mental Hlth & Sensory Organs, Rome, Italy.
C3 Universita della Campania Vanvitelli; University of Cagliari; Sapienza
   University Rome
RP Fiorillo, A (corresponding author), Univ Naples SUN, Dept Psychiat, Naples, Italy.
EM andrea.fiorillo@unina2.it
RI Pompili, Maurizio/AAC-1011-2019; Pinna, Federica/LRU-3388-2024;
   Fiorillo, Andrea/AHH-4551-2022; Sampogna, Gaia/AHH-4608-2022
OI Pinna, Federica/0000-0002-3108-9509; Fiorillo,
   Andrea/0000-0002-6926-0762; Sampogna, Gaia/0000-0002-9547-2793; ,
   Vincenzo/0000-0003-3294-1748; Luciano, Mario/0000-0002-4338-1371
CR Alvarez-Jimenez M, 2015, EVID-BASED MENT HEAL, V18, P127, DOI 10.1136/eb-2015-102178
   [Anonymous], 2014, PSYCH SCHIZ AD PREV
   [Anonymous], GIORN ITAL PSICOPAT
   [Anonymous], MENT HLTH CHRON PHYS
   [Anonymous], PRIM CARE COMPANION
   Attux C, 2013, BMC PSYCHIATRY, V13, DOI 10.1186/1471-244X-13-60
   Baker AL, 2015, NICOTINE TOB RES, V17, P946, DOI [10.1093, 10.1093/ntr/ntv039]
   Baller JB, 2015, BMC PSYCHIATRY, V15, DOI 10.1186/s12888-015-0416-y
   Bartoli F, 2017, J PSYCHIATR RES, V88, P38, DOI 10.1016/j.jpsychires.2016.12.021
   Bauer IE, 2016, J PSYCHIATR RES, V74, P1, DOI 10.1016/j.jpsychires.2015.12.006
   Biddle S, 2016, WORLD PSYCHIATRY, V15, P176, DOI 10.1002/wps.20331
   Bruins J, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0112276
   Busch AM, 2013, OBESITY, V21, pE211, DOI 10.1002/oby.20113
   Calvo A, 2015, J AM ACAD CHILD PSY, V54, P984, DOI 10.1016/j.jaac.2015.09.018
   Chartier IS, 2013, J AFFECT DISORDERS, V145, P292, DOI 10.1016/j.jad.2012.07.023
   Cole MG, 2008, AM J GERIAT PSYCHIAT, V16, P435, DOI 10.1097/JGP.0b013e318162f174
   Colom F, 2014, WORLD PSYCHIATRY, V13, P90, DOI 10.1002/wps.20091
   Correll CU, 2015, WORLD PSYCHIATRY, V14, P119, DOI 10.1002/wps.20204
   Corruble E, 2015, WORLD PSYCHIATRY, V14, P366, DOI 10.1002/wps.20260
   Danner U, 2017, FORTSCHR NEUROL PSYC, V85, P86, DOI 10.1055/s-0042-124506
   De Hert M, 2012, CNS DRUGS, V26, P733, DOI 10.2165/11634500-000000000-00000
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P138
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P52, DOI 10.1002/j.2051-5545.2011.tb00014.x
   Dipasquale S, 2013, J PSYCHIATR RES, V47, P197, DOI 10.1016/j.jpsychires.2012.10.005
   Faulkner G, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005148.pub2
   Fiorillo A, 2016, J AFFECT DISORDERS, V190, P657, DOI 10.1016/j.jad.2015.10.060
   Fiorillo A, 2015, J AFFECT DISORDERS, V172, P291, DOI 10.1016/j.jad.2014.10.021
   Fiorillo A, 2013, WORLD PSYCHIATRY, V12, P165, DOI 10.1002/wps.20052
   Firth J, 2016, PSYCHOL MED, V46, P2869, DOI 10.1017/S0033291716001732
   Firth J., 2016, Early Intervention in Psychiatry
   Firth J, 2017, SCHIZOPHRENIA BULL, V43, P546, DOI 10.1093/schbul/sbw115
   Forsman AK, 2015, EUR J PUBLIC HEALTH, V25, P249, DOI 10.1093/eurpub/cku232
   Forsyth A, 2015, PSYCHIAT RES, V230, P537, DOI 10.1016/j.psychres.2015.10.001
   Frank E, 2015, BIPOLAR DISORD, V17, P424, DOI 10.1111/bdi.12283
   Goldberg RW, 2013, PSYCHIAT SERV, V64, P737, DOI 10.1176/appi.ps.201200314
   Gonzalez-Valderrama A, 2015, FRONT PSYCHIATRY, V6, DOI 10.3389/fpsyt.2015.00051
   Goracci A, 2016, J AFFECT DISORDERS, V196, P20, DOI 10.1016/j.jad.2016.02.034
   Green CA, 2015, AM J PSYCHIAT, V172, P71, DOI 10.1176/appi.ajp.2014.14020173
   Green CA, 2014, COMMUNITY MENT HLT J, V50, P974, DOI 10.1007/s10597-014-9716-9
   Guyatt GH, 2011, J CLIN EPIDEMIOL, V64, P1294, DOI 10.1016/j.jclinepi.2011.03.017
   Hardy S, 2013, J MENT HEALTH, V22, P42, DOI 10.3109/09638237.2012.759194
   Hayes JF, 2016, WORLD PSYCHIATRY, V15, P53, DOI 10.1002/wps.20298
   Hjorth P, 2014, AUST NZ J PSYCHIAT, V48, P861, DOI 10.1177/0004867414533011
   Iglesias-García C, 2010, J PSYCHIATR MENT HLT, V17, P849, DOI 10.1111/j.1365-2850.2010.01590.x
   Fernández-San-Martín MI, 2014, COMMUNITY MENT HLT J, V50, P81, DOI 10.1007/s10597-013-9614-6
   Kilbourne AM, 2013, J CLIN PSYCHIAT, V74, pE655, DOI 10.4088/JCP.12m08082
   Krämer LV, 2014, PSYCHOL HEALTH, V29, P1206, DOI 10.1080/08870446.2014.918978
   Lesage A, 2015, CAN J PSYCHIAT, V60, P571, DOI 10.1177/070674371506001208
   Leucht S., 2007, Physical illness and schizophrenia: A Review of the Evidence
   Lobelo F, 2016, PROG CARDIOVASC DIS, V58, P584, DOI 10.1016/j.pcad.2016.02.007
   Lord O, 2010, GEN HOSP PSYCHIAT, V32, P519, DOI 10.1016/j.genhosppsych.2010.04.004
   Luciano M, 2012, EXPERT REV NEUROTHER, V12, P83, DOI [10.1586/ern.11.131, 10.1586/ERN.11.131]
   Magliano L, 2006, PSYCHIAT SERV, V57, P266, DOI 10.1176/appi.ps.57.2.266
   Malchow B, 2015, SCHIZOPHRENIA BULL, V41, P847, DOI 10.1093/schbul/sbv020
   Masa-Font R, 2015, EUR PSYCHIAT, V30, P1028, DOI 10.1016/j.eurpsy.2015.09.006
   Methapatara W, 2011, PSYCHIAT CLIN NEUROS, V65, P374, DOI 10.1111/j.1440-1819.2011.02225.x
   Mitchell AJ, 2015, GEN HOSP PSYCHIAT, V37, P14, DOI 10.1016/j.genhosppsych.2014.11.006
   Moore S, 2015, ACTA PSYCHIAT SCAND, V132, P109, DOI 10.1111/acps.12431
   Naslund JA, 2016, AM J PREV MED, V50, P145, DOI 10.1016/j.amepre.2015.07.012
   Naslund JA, 2015, TELEMED E-HEALTH, V21, P213, DOI 10.1089/tmj.2014.0105
   Petrakis M, 2013, INT J SOC PSYCHIATR, V59, P391, DOI 10.1177/0020764012438476
   Pingani L, 2013, INT J SOC PSYCHIATR, V59, P701, DOI 10.1177/0020764012453812
   Popay J., A product from the ESRC methods programme Version
   Recio-Rodríguez JI, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-254
   Reinares M, 2014, J AFFECT DISORDERS, V156, P46, DOI 10.1016/j.jad.2013.12.017
   Rimes RR, 2015, CNS NEUROL DISORD-DR, V14, P1244, DOI 10.2174/1871527315666151111130659
   Rosenbaum S, 2015, BRIT J SPORT MED, V49, P1544, DOI 10.1136/bjsports-2014-094314
   Schlosser D, 2016, JMIR RES PROTOC, V5, DOI 10.2196/resprot.5450
   Schroeder SA, 2016, WORLD PSYCHIATRY, V15, P175, DOI 10.1002/wps.20332
   Schuch F, 2017, J AFFECT DISORDERS, V210, P139, DOI 10.1016/j.jad.2016.10.050
   Soundy A, 2014, PSYCHIAT SERV, V65, P693, DOI 10.1176/appi.ps.201300276
   Speyer H, 2016, WORLD PSYCHIATRY, V15, P155, DOI 10.1002/wps.20318
   Speyer H, 2015, BMC PSYCHIATRY, V15, DOI 10.1186/s12888-015-0465-2
   Stubbs B, 2016, SCHIZOPHR RES, V176, P431, DOI 10.1016/j.schres.2016.05.017
   Stubbs B, 2016, SCHIZOPHR RES, V171, P103, DOI 10.1016/j.schres.2016.01.034
   Stubbs B, 2016, J AFFECT DISORDERS, V190, P457, DOI 10.1016/j.jad.2015.10.019
   Sylvia LG, 2013, INT J BIPOLAR DISORD, V1, DOI 10.1186/2194-7511-1-24
   Sylvia LG, 2011, J PSYCHIATR PRACT, V17, P224, DOI 10.1097/01.pra.0000398419.82362.32
   Taylor J, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0168549
   Teasdale SB, 2017, BRIT J PSYCHIAT, V210, P110, DOI 10.1192/bjp.bp.115.177139
   Temmingh H, 2013, J NERV MENT DIS, V201, P977, DOI 10.1097/NMD.0000000000000036
   Thornicroft G, 2011, BRIT J PSYCHIAT, V199, P441, DOI 10.1192/bjp.bp.111.092718
   Vancampfort D, 2017, SPORTS MED, V47, P343, DOI 10.1007/s40279-016-0574-1
   Vancampfort D, 2016, J AFFECT DISORDERS, V201, P145, DOI 10.1016/j.jad.2016.05.020
   Vancampfort D, 2016, WORLD PSYCHIATRY, V15, P166, DOI 10.1002/wps.20309
   Vancampfort D, 2016, GEN HOSP PSYCHIAT, V39, P15, DOI 10.1016/j.genhosppsych.2015.11.008
   Vancampfort D, 2015, PREV MED, V81, P216, DOI 10.1016/j.ypmed.2015.09.006
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vancampfort D, 2015, PSYCHIAT RES, V228, P100, DOI 10.1016/j.psychres.2015.04.021
   Verhaeghe N, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-657
   Verhaeghe N, 2011, INT J BEHAV NUTR PHY, V8, DOI 10.1186/1479-5868-8-28
   Walker ER, 2015, JAMA PSYCHIAT, V72, P334, DOI 10.1001/jamapsychiatry.2014.2502
NR 92
TC 40
Z9 40
U1 0
U2 35
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1473-7175
EI 1744-8360
J9 EXPERT REV NEUROTHER
JI Expert Rev. Neurother.
PY 2017
VL 17
IS 7
BP 667
EP 681
DI 10.1080/14737175.2017.1325321
PG 15
WC Clinical Neurology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA EX7EZ
UT WOS:000403412200005
PM 28468528
DA 2025-06-11
ER

PT J
AU Wickrama, T
   Merten, MJ
   Wickrama, KAS
AF Wickrama, Thulitha
   Merten, Michael J.
   Wickrama, K. A. S.
TI Early community influence on young adult physical health: Race/ethnicity
   and gender differences
SO ADVANCES IN LIFE COURSE RESEARCH
LA English
DT Article
DE Community; Childhood; Young adulthood; Physical health; Race/ethnicity;
   Adolescence
ID ARTERY RISK DEVELOPMENT; METABOLIC SYNDROME; MENTAL-HEALTH; RESIDENTIAL
   SEGREGATION; HEART-DISEASE; LIFE-COURSE; CHILDREN; FAMILY; SUPPORT;
   ASSOCIATION
AB The purpose of this study was to examine the implications of childhood community contexts in the U.S. for physical health problems related to impaired metabolic conditions, and coronary/cardiovascular diseases during young adulthood. Data came from Waves 1 and 4 (1995 and 2008) of the National Longitudinal Study of Adolescent Health (N = 11,845). Multilevel logistic-normal regression was used to examine the relative risk or odds ratios of physical health problems in young adulthood (2008), based on both 1990 census level and 1995 survey data. Childhood community disadvantage and minority concentration increased the risk of young adult obesity, hypertension, diabetes, and high cholesterol. However, the influence of both community disadvantage and minority concentration on young adult physical health outcomes differed by race/ethnicity. Our findings clearly point to the increased risk of physical health problems related to coronary and cardiovascular diseases when a child is raised in an adverse and minority concentrated community. This influence of the community was pervasive and independent of family characteristics. Programs should combat adverse community conditions and enhance resiliencies of youth and families living in such communities. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Wickrama, Thulitha] Auburn Univ, Dept Human Dev & Family Studies, Auburn, AL 36849 USA.
   [Merten, Michael J.] Oklahoma State Univ, Dept Human Dev & Family Sci, Tulsa, OK 74106 USA.
   [Wickrama, K. A. S.] Univ Georgia, Dept Child & Family Dev, Athens, GA 30602 USA.
C3 Auburn University System; Auburn University; Oklahoma State University
   System; Oklahoma State University - Tulsa; University System of Georgia;
   University of Georgia
RP Wickrama, T (corresponding author), Auburn Univ, Dept Human Dev & Family Studies, 288 Spidle Hall, Auburn, AL 36849 USA.
EM tzw0003@auburn.edu; michael.merten@okstate.edu; wickrama@uga.edu
CR Abramovitz BA, 2000, J AM DIET ASSOC, V100, P1157, DOI 10.1016/S0002-8223(00)00339-4
   Acevedo-Garcia D, 2003, AM J PUBLIC HEALTH, V93, P215, DOI 10.2105/AJPH.93.2.215
   [Anonymous], 1942, JUVENILE DELINQUENCY
   Backett-Milburn KC, 2006, SOC SCI MED, V63, P624, DOI 10.1016/j.socscimed.2006.02.011
   Bandura A., 1977, Social Learning Theory
   Barrett AE, 2005, J HEALTH SOC BEHAV, V46, P156, DOI 10.1177/002214650504600203
   Bell RA., 2009, Diabetes Care, V32
   Birch LL, 1998, PEDIATRICS, V101, P539
   BRONFENBRENNER U, 1977, AM PSYCHOL, V32, P513, DOI 10.1037/0003-066x.32.7.513
   Browning CR, 2003, J HEALTH SOC BEHAV, V44, P552, DOI 10.2307/1519799
   Calzada PJ, 2009, PRIMARY CARE, V36, P307, DOI 10.1016/j.pop.2009.01.007
   Ceballo R, 2002, CHILD DEV, V73, P1310, DOI 10.1111/1467-8624.00473
   Centers for Disease Control, 2008, HLTH US SPEC FEAT HL
   Chantala K., 2004, Non-response in Wave III
   Dannefer D, 2003, J GERONTOL B-PSYCHOL, V58, pS327, DOI 10.1093/geronb/58.6.S327
   DiLorenzo TM, 1998, PREV MED, V27, P470, DOI 10.1006/pmed.1998.0307
   DiPrete TA, 2006, ANNU REV SOCIOL, V32, P271, DOI 10.1146/annurev.soc.32.061604.123127
   Duncan GE, 2004, DIABETES CARE, V27, P2438, DOI 10.2337/diacare.27.10.2438
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Entwisle B, 2007, DEMOGRAPHY, V44, P687, DOI 10.1353/dem.2007.0045
   Evans GW, 2004, AM PSYCHOL, V59, P77, DOI 10.1037/0003-066X.59.2.77
   Ferraro KF, 2003, AM SOCIOL REV, V68, P707, DOI 10.2307/1519759
   Fomby P, 2007, AM SOCIOL REV, V72, P181, DOI 10.1177/000312240707200203
   Gable S, 2000, FAM RELAT, V49, P293, DOI 10.1111/j.1741-3729.2000.00293.x
   Girod JP, 2003, MED HYPOTHESES, V60, P584, DOI 10.1016/S0306-9877(03)00053-7
   Halpern-Meekin S, 2008, J MARRIAGE FAM, V70, P435, DOI 10.1111/j.1741-3737.2008.00492.x
   Hansen ML, 2007, JAMA-J AM MED ASSOC, V298, P874, DOI 10.1001/jama.298.8.874
   *HARV MED SCH HLTH, 1998, HARVARD HLTH LETT, V23, P1
   Haworth-Hoeppner S, 2000, J MARRIAGE FAM, V62, P212, DOI 10.1111/j.1741-3737.2000.00212.x
   Hortz B, 2009, J RURAL HEALTH, V25, P58, DOI 10.1111/j.1748-0361.2009.00199.x
   Jeffreys M, 2006, INT J OBESITY, V30, P507, DOI 10.1038/sj.ijo.0803161
   Jencks C., 1990, INNER CITY POVERTY U, P111, DOI DOI 10.17226/1539
   KAPLAN GA, 1995, PSYCHOSOM MED, V57, P208, DOI 10.1097/00006842-199505000-00002
   Kitai E, 2007, ISR MED ASSOC J, V9, P8
   Kowaleski-Jones L, 2000, J MARRIAGE FAM, V62, P449, DOI 10.1111/j.1741-3737.2000.00449.x
   Lindsay AC, 2006, FUTURE CHILD, V16, P169, DOI 10.1353/foc.2006.0006
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   Marmot M., 2008, CLOSING GAP GENERATI
   McLoyd V., 2009, Handbook of Adolescent Psychology
   Melchior M, 2007, AM J EPIDEMIOL, V166, P966, DOI 10.1093/aje/kwm155
   Merten MJ, 2010, OBESITY, V18, P1423, DOI 10.1038/oby.2009.365
   MERTON RK, 1968, SCIENCE, V159, P56, DOI 10.1126/science.159.3810.56
   Neumark-Sztainer D, 2000, J NUTR EDUC, V32, P329, DOI 10.1016/S0022-3182(00)70592-9
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Pollitt RA, 2005, BMC PUBLIC HEALTH, V5, DOI 10.1186/1471-2458-5-7
   Prochaska JJ, 2002, RES Q EXERCISE SPORT, V73, P206, DOI 10.1080/02701367.2002.10609010
   Richmond TK, 2007, INT J PEDIATR OBES, V2, P202, DOI 10.1080/17477160701305781
   Ross CE, 2009, J HEALTH SOC BEHAV, V50, P49, DOI 10.1177/002214650905000104
   Roux AVD, 2002, DIABETES CARE, V25, P1976, DOI 10.2337/diacare.25.11.1976
   Sampson RJ, 2002, ANNU REV SOCIOL, V28, P443, DOI 10.1146/annurev.soc.28.110601.141114
   Santana P, 2009, SOC SCI MED, V68, P601, DOI 10.1016/j.socscimed.2008.11.033
   Spencer MB, 2001, DOES IT TAKE A VILLAGE?, P51
   Sweeney MM, 2007, J HEALTH SOC BEHAV, V48, P33, DOI 10.1177/002214650704800103
   Taylor SE, 2006, BIOL PSYCHIAT, V60, P819, DOI 10.1016/j.biopsych.2006.03.016
   Thom T, 2006, CIRCULATION, V113, pE85, DOI 10.1161/CIRCULATIONAHA.105.171600
   van Jaarsveld CHM, 2009, OBESITY, V17, P2155, DOI 10.1038/oby.2009.183
   Wheaton B, 2003, AM SOCIOL REV, V68, P680, DOI 10.2307/1519758
   Wickrama KAT, 2006, J YOUTH ADOLESCENCE, V35, P647, DOI 10.1007/s10964-006-9050-9
   Wickrama KAS, 2003, J MARRIAGE FAM, V65, P850, DOI 10.1111/j.1741-3737.2003.00850.x
   Wickrama KAS, 2005, J COMMUNITY PSYCHOL, V33, P639, DOI 10.1002/jcop.20076
   Wickrama KAS, 1997, J HEALTH SOC BEHAV, V38, P149, DOI 10.2307/2955422
   Williams DR, 2001, PUBLIC HEALTH REP, V116, P404, DOI 10.1016/S0033-3549(04)50068-7
   Wilson W., 1987, TRULY DISADVANTAGED
   Windle M, 2004, AM J PREV MED, V27, P164, DOI 10.1016/j.amepre.2004.04.007
   Wormald H, 2006, BMC PUBLIC HEALTH, V6, DOI 10.1186/1471-2458-6-202
   Zenk SN, 2008, HEALTH PLACE, V14, P336, DOI 10.1016/j.healthplace.2007.08.003
   Zenk SN, 2005, AM J PUBLIC HEALTH, V95, P660, DOI 10.2105/AJPH.2004.042150
NR 67
TC 10
Z9 11
U1 2
U2 16
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1040-2608
J9 ADV LIFE COURSE RES
JI Adv. Life Course Res.
PD MAR
PY 2012
VL 17
IS 1
BP 25
EP 33
DI 10.1016/j.alcr.2012.01.001
PG 9
WC Social Sciences, Interdisciplinary
WE Social Science Citation Index (SSCI)
SC Social Sciences - Other Topics
GA 912AF
UT WOS:000301765100003
DA 2025-06-11
ER

PT J
AU Akbar, Z
   Shi, ZM
AF Akbar, Zoha
   Shi, Zumin
TI Dietary Patterns and Circadian Syndrome among Adults Attending NHANES
   2005-2016
SO NUTRIENTS
LA English
DT Article
DE diet; dietary patterns; circadian rhythms; circadian syndrome; NHANES
ID METABOLIC SYNDROME; SLEEP; PREGNANCY; RHYTHMS; CLOCK; METAANALYSIS;
   DISEASE; HEALTH; RISK
AB The study aimed to assess the associations of dietary patterns and circadian syndrome (CircS). Data from National Health and Nutrition Examination Survey (NHANES) 2005-2016 were analyzed (n = 10,486). Factor analysis was used to construct dietary patterns based on two 24 h food recalls. CircS was defined based on components of the metabolic syndrome, with the addition of short sleep and depression symptoms. Multivariable logistic regression was used to analyze the associations. Two major dietary patterns were identified. The Western dietary pattern had high loadings of refined grains, solid fats, added sugars, and red and cured meats, while the prudent pattern was characterized by a high intake of vegetables, whole grains, oils, nuts, and seeds. The prevalence of CircS was 41.3%. Comparing extreme quartiles of intake, the odds ratios (OR) for having CircS were 1.96 (95%CI 1.53-2.53) and 0.71 (95%CI 0.58-0.86) for the Western pattern and prudent pattern, respectively. The association between the Western dietary pattern and CircS was stronger among men (OR = 2.05; 95%CI 1.48-2.85) and those with low income (OR = 1.94; 95%CI 1.27-2.96) and high education (OR = 3.38; 95%CI 1.90-6.04). The Western dietary pattern was associated with a higher likelihood of having CircS, while the prudent pattern was inversely associated with CircS.
C1 [Akbar, Zoha; Shi, Zumin] Qatar Univ, Coll Hlth Sci, Human Nutr Dept, QU Hlth, POB 2713, Doha, Qatar.
C3 Qatar University
RP Shi, ZM (corresponding author), Qatar Univ, Coll Hlth Sci, Human Nutr Dept, QU Hlth, POB 2713, Doha, Qatar.
EM za1404491@qu.edu.qa; zumin@qu.edu.qa
RI Shi, Zumin/A-1093-2009
OI Shi, Zumin/0000-0002-3099-3299; Akbar, Zoha/0000-0002-7287-0027
FU Qatar University [QUST-1-CHS-2023-810]
FX This research was supported by the Qatar University student grant
   QUST-1-CHS-2023-810.
CR Afshin A, 2019, LANCET, V393, P1958, DOI 10.1016/S0140-6736(19)30041-8
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Asher G, 2011, CELL METAB, V13, P125, DOI 10.1016/j.cmet.2011.01.006
   Bellet MM, 2011, COLD SH Q B, V76, P31, DOI 10.1101/sqb.2011.76.010520
   Berryman CE, 2021, CLIN NUTR, V40, P4301, DOI 10.1016/j.clnu.2021.01.018
   Bhutta N., 2020, FEDS Notes, DOI DOI 10.17016/2380-7172.2797
   Cao YT, 2017, ASIA PAC J CLIN NUTR, V26, P1158, DOI 10.6133/apjcn.122016.03
   Castro-Diehl C, 2018, SLEEP, V41, DOI 10.1093/sleep/zsy158
   cdc.gov, NHANES WHAT WE EAT A
   Clark AM, 2009, NAT REV CARDIOL, V6, P712, DOI 10.1038/nrcardio.2009.163
   Crnko S, 2019, NAT REV CARDIOL, V16, P437, DOI 10.1038/s41569-019-0167-4
   Eckel-Mahan K, 2009, NAT STRUCT MOL BIOL, V16, P462, DOI 10.1038/nsmb.1595
   Fabiani R, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092056
   Ferraz-Bannitz R, 2021, BIOLOGY-BASEL, V10, DOI 10.3390/biology10030197
   Gramaglia C, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00621
   Groop L, 2000, BRIT J NUTR, V83, pS39
   Hou WY, 2021, J CLIN ENDOCR METAB, V106, pE2480, DOI 10.1210/clinem/dgab288
   Hu FB, 2000, AM J CLIN NUTR, V72, P912
   Hu XM, 2023, SCI TOTAL ENVIRON, V868, DOI 10.1016/j.scitotenv.2023.161696
   Itani O, 2017, SLEEP MED, V32, P246, DOI 10.1016/j.sleep.2016.08.006
   Javeed N, 2018, PHYSIOLOGY, V33, P138, DOI 10.1152/physiol.00003.2018
   Jayedi A, 2020, BRIT J NUTR, V124, P1133, DOI 10.1017/S0007114520002330
   Kohsaka A, 2007, CELL METAB, V6, P414, DOI 10.1016/j.cmet.2007.09.006
   Lassale C, 2019, MOL PSYCHIATR, V24, P965, DOI 10.1038/s41380-018-0237-8
   Li DY, 2021, CHRONOBIOL INT, V38, P762, DOI 10.1080/07420528.2021.1889579
   Lopez DEG, 2021, CELL METAB, V33, P873, DOI 10.1016/j.cmet.2021.03.015
   Minhas AMK, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-27474-x
   Moshfegh AJ, 2008, AM J CLIN NUTR, V88, P324
   Nauli AM, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.01486
   Nayak N, 2021, LIFE SCI, V281, DOI 10.1016/j.lfs.2021.119758
   Panda S, 2019, NAT REV ENDOCRINOL, V15, P67, DOI 10.1038/s41574-018-0142-x
   Patterson RE, 2017, ANNU REV NUTR, V37, P371, DOI 10.1146/annurev-nutr-071816-064634
   Paula ABR, 2022, METABOLITES, V12, DOI 10.3390/metabo12121273
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Rippin HL, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0232447
   Rodríguez-Monforte M, 2017, EUR J NUTR, V56, P925, DOI 10.1007/s00394-016-1305-y
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Scoditti E, 2022, NUTRIENTS, V14, DOI 10.3390/nu14142998
   Sedov ID, 2018, SLEEP MED REV, V38, P168, DOI 10.1016/j.smrv.2017.06.005
   Shab-Bidar S, 2018, PUBLIC HEALTH NUTR, V21, P1681, DOI [10.1017/S1368980018000216, 10.1017/s1368980018000216]
   Shi Z, 2021, J INTERN MED, V289, P851, DOI 10.1111/joim.13204
   Shi ZM, 2022, NUTRIENTS, V14, DOI 10.3390/nu14245317
   Shin D, 2015, NUTRIENTS, V7, P9369, DOI 10.3390/nu7115472
   Smolensky MH, 2007, SLEEP MED, V8, P668, DOI 10.1016/j.sleep.2006.11.011
   Staels B, 2006, NAT MED, V12, P54, DOI 10.1038/nm0106-54
   U.S. Department of Agriculture, AV HLTH EAT IND 2015
   Vgontzas AN, 2005, SLEEP MED REV, V9, P211, DOI 10.1016/j.smrv.2005.01.006
   Wang YL, 2022, FRONT NEUROL, V13, DOI 10.3389/fneur.2022.946172
   Wilsnack RW, 2018, ALCOHOL RES-CURR REV, V39, P57
   Xiao YF, 2023, BMC PUBLIC HEALTH, V23, DOI 10.1186/s12889-023-15934-y
   Xiao YF, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1137668
   Xiong Y, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.715830
   Xu YJ, 2021, TRANSL PSYCHIAT, V11, DOI 10.1038/s41398-021-01590-6
   Zeng ZD, 2017, ANN NUTR METAB, V70, P59, DOI 10.1159/000459633
   Zimmet P, 2019, J INTERN MED, V286, P181, DOI 10.1111/joim.12924
   Zisapel N, 2018, BRIT J PHARMACOL, V175, P3190, DOI 10.1111/bph.14116
   Zitting KM, 2022, METABOLISM, V130, DOI 10.1016/j.metabol.2022.155158
NR 58
TC 12
Z9 12
U1 3
U2 28
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2023
VL 15
IS 15
AR 3396
DI 10.3390/nu15153396
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA O7NE6
UT WOS:001045625700001
PM 37571333
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Boleti, APD
   Cardoso, PHD
   Frihling, BEF
   Silva, PSE
   de Moraes, LFRN
   Migliolo, L
AF Boleti, Ana Paula de A.
   Cardoso, Pedro Henrique de O.
   Frihling, Breno Emanuel F.
   Souza e Silva, Patricia
   de Moraes, Luiz Filipe R. N.
   Migliolo, Ludovico
TI Adipose tissue, systematic inflammation, and neurodegenerative diseases
SO NEURAL REGENERATION RESEARCH
LA English
DT Review
DE adiposity; anti-obesity drugs; hypothalamic inflammation; metabolic
   disease; neurodegenerative disease; neuroinflammation
ID BODY-MASS INDEX; BETA/NF-KAPPA-B; WEIGHT-LOSS; COGNITIVE FUNCTION;
   LIPASE INHIBITOR; METABOLIC SYNDROME; RECEPTOR AGONISTS; GLYCEMIC
   CONTROL; GASTRIC BYPASS; CLINICAL-TRIAL
AB Obesity is associated with several diseases, including mental health. Adipose tissue is distributed around the internal organs, acting in the regulation of metabolism by storing and releasing fatty acids and adipokine in the tissues. Excessive nutritional intake results in hypertrophy and proliferation of adipocytes, leading to local hypoxia in adipose tissue and changes in these adipokine releases. This leads to the recruitment of immune cells to adipose tissue and the release of pro-inflammatory cytokines. The presence of high levels of free fatty acids and inflammatory molecules interfere with intracellular insulin signaling, which can generate a neuroinflammatory process. In this review, we provide an up-to-date discussion of how excessive obesity can lead to possible cognitive dysfunction. We also address the idea that obesity-associated systemic inflammation leads to neuroinflammation in the brain, particularly the hypothalamus and hippocampus, and that this is partially responsible for these negative cognitive outcomes. In addition, we discuss some clinical models and animal studies for obesity and clarify the mechanism of action of anti-obesity drugs in the central nervous system.
C1 [Boleti, Ana Paula de A.; Cardoso, Pedro Henrique de O.; Frihling, Breno Emanuel F.; Souza e Silva, Patricia; de Moraes, Luiz Filipe R. N.; Migliolo, Ludovico] Univ Catolica Dom Bosco, Programa Posgrad Biotecnol, S Inova Biotech, Campo Grande, MS, Brazil.
   [Migliolo, Ludovico] Univ Fed Rio Grande do Norte, Programa Posgrad Bioquim, Programa Posgrad Biol Celular & Mol, Natal, RN, Brazil.
C3 Universidade Catolica Dom Bosco (UCDB); Universidade Federal do Rio
   Grande do Norte
RP Migliolo, L (corresponding author), Univ Catolica Dom Bosco, Programa Posgrad Biotecnol, S Inova Biotech, Campo Grande, MS, Brazil.; Migliolo, L (corresponding author), Univ Fed Rio Grande do Norte, Programa Posgrad Bioquim, Programa Posgrad Biol Celular & Mol, Natal, RN, Brazil.
EM ludovico@ucdb.br
RI Migliolo, Ludovico/AAV-6913-2021; Cardoso, Pedro/B-3546-2019; De
   Oliveira Cardoso, Pedro Henrique/KUF-2487-2024
OI Frihling, Breno Emanuel/0000-0002-3749-9410; MIGLIOLO,
   LUDOVICO/0000-0002-6606-2189; De Oliveira Cardoso, Pedro
   Henrique/0000-0002-2872-3767
FU Brazilian funding agency CNPq; Brazilian funding agency FUNDECT
FX This work was supported by the Brazilian funding agencies CNPq, and
   FUNDECT (to LM).
CR Abdul-Ghani MA, 2013, DIABETES, V62, P3324, DOI 10.2337/db13-0604
   Adan RAH, 2008, TRENDS PHARMACOL SCI, V29, P208, DOI 10.1016/j.tips.2008.01.008
   Agustí A, 2018, FRONT NEUROSCI-SWITZ, V12, DOI 10.3389/fnins.2018.00155
   Ahrén B, 2017, LANCET DIABETES ENDO, V5, P341, DOI 10.1016/S2213-8587(17)30092-X
   Alisi A, 2014, ALIMENT PHARM THER, V39, P1276, DOI 10.1111/apt.12758
   Alosco ML, 2014, AM J SURG, V207, P870, DOI 10.1016/j.amjsurg.2013.05.018
   André P, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081887
   Anstey KJ, 2011, OBES REV, V12, pe426, DOI 10.1111/j.1467-789X.2010.00825.x
   Ashrafian H, 2013, METAB BRAIN DIS, V28, P341, DOI 10.1007/s11011-013-9412-4
   Avgerinos KI, 2019, METABOLISM, V92, P121, DOI 10.1016/j.metabol.2018.11.001
   Bartsch T, 2015, NEUROSCIENCE, V309, P1, DOI 10.1016/j.neuroscience.2015.07.084
   Benzler J, 2015, DIABETES, V64, P2015, DOI 10.2337/db14-0093
   Berger NA, 2014, ANN NY ACAD SCI, V1311, P57, DOI 10.1111/nyas.12416
   Bialecka-Florjanczyk E, 2018, MINI-REV MED CHEM, V18, P672, DOI 10.2174/1389557516666160630123356
   Bielawiec P, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00114
   Biessels GJ, 2014, LANCET DIABETES ENDO, V2, P246, DOI 10.1016/S2213-8587(13)70088-3
   Birn RM, 2019, J NEUROSCI, V39, P1436, DOI 10.1523/JNEUROSCI.2513-18.2018
   Blaszkiewicz M, 2019, BIOLOGY-BASEL, V8, DOI 10.3390/biology8010010
   Blundell J, 2017, DIABETES OBES METAB, V19, P1242, DOI 10.1111/dom.12932
   Bocarsly ME, 2015, P NATL ACAD SCI USA, V112, P15731, DOI 10.1073/pnas.1511593112
   Boleti APD, 2022, NEUROSCI BIOBEHAV R, V132, P1214, DOI 10.1016/j.neubiorev.2020.09.027
   Brown PD, 2016, JAMA-J AM MED ASSOC, V316, P401, DOI 10.1001/jama.2016.9839
   Bryson A, 2009, BRIT J CLIN PHARMACO, V67, P309, DOI 10.1111/j.1365-2125.2008.03311.x
   Cai DS, 2012, AGING-US, V4, P98, DOI 10.18632/aging.100431
   Cao HM, 2008, CELL, V134, P933, DOI 10.1016/j.cell.2008.07.048
   Carabotti M, 2015, ANN GASTROENTEROL, V28, P203
   Castanon N, 2015, FRONT NEUROSCI-SWITZ, V9, DOI 10.3389/fnins.2015.00229
   Cattaneo A, 2017, NEUROBIOL AGING, V49, P60, DOI 10.1016/j.neurobiolaging.2016.08.019
   Chen KY, 2015, J CLIN ENDOCR METAB, V100, P1639, DOI 10.1210/jc.2014-4024
   Chen WW, 2016, MOL MED REP, V13, P3391, DOI 10.3892/mmr.2016.4948
   Chen Y, 2016, DRUG DISCOV THER, V10, P62, DOI 10.5582/ddt.2016.01014
   Cheng L, 2021, ADIPOCYTE, V10, P48, DOI 10.1080/21623945.2020.1870060
   Chi LT, 2018, J CEREBR BLOOD F MET, V38, P479, DOI 10.1177/0271678X17697988
   Chiang HL, 2019, J MOV DISORD, V12, P67, DOI 10.14802/jmd.18067
   Cho JS, 2021, CNS NEUROSCI THER, V27, P505, DOI 10.1111/cns.13613
   Cinti S, 2018, COMPR PHYSIOL, V8, P1357, DOI 10.1002/cphy.c170042
   Coulter AA, 2018, DRUGS, V78, P1113, DOI 10.1007/s40265-018-0946-y
   da Luz FQ, 2018, NUTRIENTS, V10, DOI 10.3390/nu10070829
   Dahl AK, 2013, EPIDEMIOL REV, V35, P22, DOI 10.1093/epirev/mxs002
   Boleti APD, 2020, NEUROCHEM INT, V136, DOI 10.1016/j.neuint.2020.104714
   de Azua IR, 2019, CELL MOL LIFE SCI, V76, P1341, DOI 10.1007/s00018-018-2994-6
   de Farias BX, 2020, NEUROCHEM RES, V45, P2487, DOI 10.1007/s11064-020-03107-x
   Di Rosa MC, 2021, LIFE-BASEL, V11, DOI 10.3390/life11111256
   Dietz W, 2020, OBESITY, V28, P1005, DOI 10.1002/oby.22818
   Dinel AL, 2014, PSYCHONEUROENDOCRINO, V40, P48, DOI 10.1016/j.psyneuen.2013.10.014
   Dohle S, 2018, APPETITE, V124, P4, DOI 10.1016/j.appet.2017.05.041
   Du LL, 2014, AGE, V36, P613, DOI 10.1007/s11357-013-9592-1
   Duffy CM, 2019, NEUROBIOL LEARN MEM, V157, P41, DOI 10.1016/j.nlm.2018.11.008
   Elks CM, 2010, CURR HYPERTENS REP, V12, P99, DOI 10.1007/s11906-010-0096-4
   Enzinger C, 2005, NEUROLOGY, V64, P1704, DOI 10.1212/01.WNL.0000161871.83614.BB
   Favre G, 2021, METABOLISM, V115, DOI 10.1016/j.metabol.2020.154440
   Fleckenstein-Elsen M, 2016, MOL NUTR FOOD RES, V60, P2065, DOI 10.1002/mnfr.201500892
   Gadde KM, 2007, J CLIN PSYCHIAT, V68, P1226, DOI 10.4088/JCP.v68n0809
   García-Sánchez A, 2020, DIABET METAB SYND OB, V13, P1077, DOI 10.2147/DMSO.S245494
   Garg SK, 2018, NEW ENGL J MED, V378, P967, DOI 10.1056/NEJMc1800394
   Goyal D, 2021, PROG NEURO-PSYCHOPH, V106, DOI 10.1016/j.pnpbp.2020.110112
   Grizenkova J, 2014, BMC NEUROSCI, V15, DOI 10.1186/1471-2202-15-44
   Gunstad J, 2010, NEUROEPIDEMIOLOGY, V34, P222, DOI 10.1159/000297742
   Guo DH, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-24540-8
   Hansen DV, 2018, J CELL BIOL, V217, P459, DOI 10.1083/jcb.201709069
   He YL, 2019, DIABETES OBES METAB, V21, P1311, DOI 10.1111/dom.13654
   Heck AM, 2000, PHARMACOTHERAPY, V20, P270, DOI 10.1592/phco.20.4.270.34882
   Heindel JJ, 2017, REPROD TOXICOL, V68, P3, DOI 10.1016/j.reprotox.2016.10.001
   Heymsfield SB, 2017, NEW ENGL J MED, V376, P254, DOI 10.1056/NEJMra1514009
   Hickman S, 2018, NAT NEUROSCI, V21, P1359, DOI 10.1038/s41593-018-0242-x
   Hofso D, 2010, EUR J ENDOCRINOL, V163, P735, DOI 10.1530/EJE-10-0514
   Hooten KG, 2015, NEUROTHERAPEUTICS, V12, P364, DOI 10.1007/s13311-014-0329-3
   Hussain A, 2020, OBES RES CLIN PRACT, V14, P295, DOI 10.1016/j.orcp.2020.07.002
   Husum H, 2003, NEUROPSYCHOPHARMACOL, V28, P1292, DOI 10.1038/sj.npp.1300178
   Isaacs D, 2016, AM J HEALTH-SYST PH, V73, P1493, DOI 10.2146/ajhp150990
   Jezek P, 2019, BBA-BIOENERGETICS, V1860, P259, DOI 10.1016/j.bbabio.2018.11.007
   Jiang SZ, 2016, EXP THER MED, V12, P2395, DOI 10.3892/etm.2016.3667
   Kälin S, 2015, NAT REV ENDOCRINOL, V11, P339, DOI 10.1038/nrendo.2015.48
   Kakkar AK, 2015, EUR J INTERN MED, V26, P89, DOI 10.1016/j.ejim.2015.01.005
   Kiortsis DN, 2013, HORM-INT J ENDOCRINO, V12, P507, DOI 10.14310/horm.2002.1438
   Kleinert M, 2018, NAT REV ENDOCRINOL, V14, P140, DOI 10.1038/nrendo.2017.161
   Kojta I, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051305
   Kopelman P, 2007, INT J OBESITY, V31, P494, DOI 10.1038/sj.ijo.0803446
   Kotsis V, 2010, HYPERTENS RES, V33, P386, DOI 10.1038/hr.2010.9
   Kowalski K, 2019, J NEUROGASTROENTEROL, V25, P48, DOI 10.5056/jnm18087
   Kumar J, 2020, MOL BIOL REP, V47, P6229, DOI 10.1007/s11033-020-05611-3
   Lam Daniel D., 2007, Expert Reviews in Molecular Medicine, V9, DOI 10.1017/S1462399407000245
   Lee THY, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22010201
   Libman IM, 2015, JAMA-J AM MED ASSOC, V314, P2241, DOI 10.1001/jama.2015.16174
   Lidell ME, 2019, HANDB EXP PHARMACOL, V251, P107, DOI 10.1007/164_2018_118
   Luo LP, 2016, J ENDOCRINOL, V231, pR77, DOI 10.1530/JOE-16-0211
   Luo P, 2019, BRAIN RES BULL, V146, P12, DOI 10.1016/j.brainresbull.2018.11.017
   Lynes MD, 2019, ENDOCRINOLOGY, V160, P2314, DOI 10.1210/en.2019-00337
   Mack CM, 2010, INT J OBESITY, V34, P385, DOI 10.1038/ijo.2009.238
   Madore C, 2020, IMMUNITY, V52, P222, DOI 10.1016/j.immuni.2019.12.003
   Madsen L, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011391
   Mainardi M, 2017, FRONT CELL NEUROSCI, V11, DOI 10.3389/fncel.2017.00225
   Maldonado-Ruiz R, 2017, NUTR DIABETES, V7, DOI 10.1038/nutd.2017.10
   Malm-Erjefalt M, 2010, DRUG METAB DISPOS, V38, P1944, DOI 10.1124/dmd.110.034066
   Martin CK, 2011, J CLIN ENDOCR METAB, V96, P837, DOI 10.1210/jc.2010-1848
   McAlpine LS, 2021, CURR OPIN PSYCHIATR, V34, P177, DOI 10.1097/YCO.0000000000000688
   McElroy SL, 2015, JAMA PSYCHIAT, V72, P235, DOI 10.1001/jamapsychiatry.2014.2162
   Meder D, 2019, NEUROIMAGE, V190, P79, DOI 10.1016/j.neuroimage.2018.11.021
   Mella Nathalie, 2018, J Intell, V6, DOI 10.3390/jintelligence6010010
   Mendes NF, 2018, METABOLISM, V85, P171, DOI 10.1016/j.metabol.2018.04.005
   Milic S, 2014, WORLD J GASTROENTERO, V20, P9330, DOI 10.3748/wjg.v20.i28.9330
   Miller AA, 2014, BRAIN BEHAV IMMUN, V42, P10, DOI 10.1016/j.bbi.2014.04.001
   Mokry LE, 2016, PLOS MED, V13, DOI 10.1371/journal.pmed.1002053
   Moraes JC, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005045
   Morita-Takemure S, 2019, NEUROCHEM INT, V128, P135, DOI 10.1016/j.neuint.2019.04.007
   Morrison SF, 2018, HAND CLINIC, V156, P281, DOI 10.1016/B978-0-444-63912-7.00017-5
   Murman Daniel L., 2015, Seminars in Hearing, V36, P111, DOI 10.1055/s-0035-1555115
   Naderali EK, 2009, AM J ALZHEIMERS DIS, V24, P445, DOI 10.1177/1533317509348208
   Narayanaswami V, 2017, PHARMACOL THERAPEUT, V170, P116, DOI 10.1016/j.pharmthera.2016.10.015
   Neuhouser ML, 2015, JAMA ONCOL, V1, P611, DOI 10.1001/jamaoncol.2015.1546
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Norregaard PK, 2018, DIABETES OBES METAB, V20, P60, DOI 10.1111/dom.13034
   Palpagama TH, 2019, FRONT MOL NEUROSCI, V12, DOI 10.3389/fnmol.2019.00258
   Panza F, 2010, J ALZHEIMERS DIS, V21, P691, DOI 10.3233/JAD-2010-091669
   Park J, 2020, FRONT IMMUNOL, V11
   Patel P, 2013, J OBES, V2013, DOI 10.1155/2013/489187
   Pavlov VA, 2021, PHARMACOL THERAPEUT, V222, DOI 10.1016/j.pharmthera.2020.107794
   Pertwee RG, 2010, CURR MED CHEM, V17, P1360, DOI 10.2174/092986710790980050
   Peterli R, 2018, JAMA-J AM MED ASSOC, V319, P255, DOI 10.1001/jama.2017.20897
   Pilitsi E, 2019, METABOLISM, V92, P170, DOI 10.1016/j.metabol.2018.10.010
   Powell AG, 2011, CLIN PHARMACOL THER, V90, P40, DOI 10.1038/clpt.2011.82
   Prickett C, 2015, OBES RES CLIN PRACT, V9, P93, DOI 10.1016/j.orcp.2014.05.001
   Qi J, 2020, BREAST CANCER-BASIC, V14, DOI 10.1177/1178223420972369
   Quach ND, 2014, BIOCHEM PHARMACOL, V90, P338, DOI 10.1016/j.bcp.2014.05.022
   Ransohoff RM, 2016, CSH PERSPECT BIOL, V8, DOI 10.1101/cshperspect.a020560
   Rao RR, 2014, CELL, V157, P1279, DOI 10.1016/j.cell.2014.03.065
   Rebello CJ, 2020, EXPERT OPIN INV DRUG, V29, P63, DOI 10.1080/13543784.2020.1705277
   Richard D, 2000, NUTRITION, V16, P961, DOI 10.1016/S0899-9007(00)00452-4
   Rocha NP, 2016, MEDIAT INFLAMM, V2016, DOI 10.1155/2016/8653132
   Rodríguez-Hernández H, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/678159
   Rossi F, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19092690
   Russell-Jones D, 2009, MOL CELL ENDOCRINOL, V297, P137, DOI 10.1016/j.mce.2008.11.018
   Sabia S, 2009, AM J CLIN NUTR, V89, P601, DOI 10.3945/ajcn.2008.26482
   Sahin S, 2014, INT J PSYCHIAT CLIN, V18, P280, DOI 10.3109/13651501.2014.940054
   Salthouse TA, 2017, J GERONTOL B-PSYCHOL, V72, P7, DOI 10.1093/geronb/gbw069
   Saltiel AR, 2017, J CLIN INVEST, V127, P1, DOI [10.1172/JCI92035, 10.1172/jci92035]
   Sari C, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.588016
   Scherer T, 2021, NAT REV ENDOCRINOL, V17, P468, DOI 10.1038/s41574-021-00498-x
   Sellbom KS, 2012, J ALZHEIMERS DIS, V30, pS89, DOI 10.3233/JAD-2011-111073
   Shank RP, 2000, EPILEPSIA, V41, pS3, DOI 10.1111/j.1528-1157.2000.tb06045.x
   Shin AC, 2019, NUTR DIABETES, V9, DOI 10.1038/s41387-019-0076-y
   Silvestri C, 2015, J HEPATOL, V62, P1382, DOI 10.1016/j.jhep.2015.01.001
   Solas M, 2017, CURR OPIN PHARMACOL, V37, P87, DOI 10.1016/j.coph.2017.10.005
   Speakman JR, 2007, CELL METAB, V6, P5, DOI 10.1016/j.cmet.2007.06.004
   Spinelli M, 2019, FRONT NEUROSCI-SWITZ, V13, DOI 10.3389/fnins.2019.00788
   Staiano AE, 2018, PEDIATR OBES, V13, P724, DOI 10.1111/ijpo.12438
   Bassi MS, 2020, MULT SCLER J, V26, P1237, DOI 10.1177/1352458519853473
   Stoll LL, 2004, ARTERIOSCL THROM VAS, V24, P2227, DOI 10.1161/01.ATV.0000147534.69062.dc
   Subhramanyam CS, 2019, SEMIN CELL DEV BIOL, V94, P112, DOI 10.1016/j.semcdb.2019.05.004
   Thompson SV, 2017, AM J CLIN NUTR, V106, P1514, DOI 10.3945/ajcn.117.163246
   Thonhoff JR, 2018, CURR OPIN NEUROL, V31, P635, DOI 10.1097/WCO.0000000000000599
   Townsend KL, 2012, ADIPOCYTE, V1, P13, DOI 10.4161/adip.18951
   Trotta M, 2020, MOL METAB, V37, DOI 10.1016/j.molmet.2020.100985
   Tuppo EE, 2005, INT J BIOCHEM CELL B, V37, P289, DOI 10.1016/j.biocel.2004.07.009
   Vamanu E, 2021, DISEASES-BASEL, V9, DOI 10.3390/diseases9030045
   Vanderheiden A, 2016, J CLIN ENDOCR METAB, V101, P1798, DOI 10.1210/jc.2015-3906
   Voet S, 2019, TRENDS MOL MED, V25, P112, DOI 10.1016/j.molmed.2018.11.005
   Wang Y, 2016, PROG NEUROBIOL, V141, P45, DOI [10.1016/j.pneurobio.2016.04.005, 10.1016/j.pneurobio.2016.04.00]
   Ward MA, 2005, BMC NEUROL, V5, DOI 10.1186/1471-2377-5-23
   Wilding J, 2018, DIABETES THER, V9, P1757, DOI 10.1007/s13300-018-0471-8
   Williams LM, 2012, P NUTR SOC, V71, P521, DOI 10.1017/S002966511200078X
   Wolf SA, 2017, ANNU REV PHYSIOL, V79, P619, DOI 10.1146/annurev-physiol-022516-034406
   Wynne K, 2006, INT J OBESITY, V30, P1729, DOI 10.1038/sj.ijo.0803344
   Xu CJ, 2018, CLIN NUTR ESPEN, V24, P148, DOI 10.1016/j.clnesp.2017.11.010
   Yang HM, 2017, FRONT AGING NEUROSCI, V9, DOI 10.3389/fnagi.2017.00193
   Zhang TH, 2019, LIPIDS HEALTH DIS, V18, DOI 10.1186/s12944-019-1170-9
   Zhang XQ, 2008, CELL, V135, P61, DOI 10.1016/j.cell.2008.07.043
   Zhao G, 2008, J MED CHEM, V51, P380, DOI 10.1021/jm7013887
   Zorena K, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21103570
NR 169
TC 37
Z9 37
U1 3
U2 69
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 1673-5374
EI 1876-7958
J9 NEURAL REGEN RES
JI Neural Regen. Res.
PD JAN
PY 2023
VL 18
IS 1
BP 38
EP 46
DI 10.4103/1673-5374.343891
PG 9
WC Cell Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Neurosciences & Neurology
GA 5H5IK
UT WOS:000867712700005
PM 35799506
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tamayo, A
   Karter, AJ
   Mujahid, MS
   Warton, EM
   Moffet, HH
   Adler, N
   Schillinger, D
   O'Connell, BH
   Laraia, B
AF Tamayo, Aracely
   Karter, Andrew J.
   Mujahid, Mahasin S.
   Warton, E. Margaret
   Moffet, Howard H.
   Adler, Nancy
   Schillinger, Dean
   O'Connell, Bethany Hendrickson
   Laraia, Barbara
TI Associations of perceived neighborhood safety and crime with
   cardiometabolic risk factors among a population with type 2 diabetes
SO HEALTH & PLACE
LA English
DT Article
DE Neighborhood; Safety; Crime; Diabetes; Obesity
ID POISSON REGRESSION APPROACH; PHYSICAL-ACTIVITY; SOCIAL-ENVIRONMENT;
   HEALTH BEHAVIORS; MANAGED CARE; PERCEPTIONS; OBESITY; RELIABILITY;
   OUTCOMES; PEOPLE
AB Little is known about how neighborhood crime may relate to health in diabetes patients. We examined associations between individuals' perceptions of neighborhood safety or violent crime and stress, physical activity, body mass index (BMI) or hemoglobin A1c (HbA1c) in a sample (n=721) of adults (mean age:63) with diabetes. Self-reported neighborhood safety, violent crime, physical activity, and stress were collected and linked to clinical measures of BMI and HbA1c. Approximately 54% and 15% of patients reported neighborhood safety concerns and violent crimes, respectively. Any neighborhood safety concerns (beta=1.14, 95% C.I. 0.04-2.24) and violent crime (beta=2.04, 95% C.I. 0.34-3.73) were associated with BMI in adjusted analysis. Any violent crime was associated with class II-III obesity (BMI >= 35) (OR=1.34, 95% C.I.:. 1.02, 1.75). There were no significant associations between neighborhood safety concerns or violent crime with stress, physical activity, or HbA1c. Neighborhood safety is associated with BMI and obesity. Further studies, including longitudinal designs, are needed to study how people with diabetes may be influenced by a sense of poor personal safety in their neighborhoods. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Tamayo, Aracely] Univ Calif Berkeley, Berkeley Sch Publ Hlth, Div Epidemiol, 101 Haviland Hall, Berkeley, CA 94720 USA.
   [Karter, Andrew J.; Warton, E. Margaret; Moffet, Howard H.] Kaiser Permanente, Div Res, Oakland, CA USA.
   [Mujahid, Mahasin S.] Univ Calif Berkeley, Sch Publ Hlth, Div Epidemiol, Berkeley, CA USA.
   [Adler, Nancy] Univ Calif San Francisco, Ctr Hlth & Community, San Francisco, CA 94143 USA.
   [Schillinger, Dean] Univ Calif San Francisco, Div Gen Internal Med, Ctr Vulnerable Populat, San Francisco Gen Hosp, San Francisco, CA 94143 USA.
   [O'Connell, Bethany Hendrickson] Univ Calif Berkeley, Ctr Weight & Hlth, Berkeley, CA USA.
   [Laraia, Barbara] UC Berkeley SPH, Community Hlth & Human Dev, Berkeley, CA USA.
C3 University of California System; University of California Berkeley;
   Kaiser Permanente; University of California System; University of
   California Berkeley; University of California System; University of
   California San Francisco; University of California System; University of
   California San Francisco; San Francisco General Hospital Medical Center;
   University of California System; University of California Berkeley
RP Tamayo, A (corresponding author), Univ Calif Berkeley, Berkeley Sch Publ Hlth, Div Epidemiol, 101 Haviland Hall, Berkeley, CA 94720 USA.
EM tamayo@berkeley.edu
RI Laraia, Barbara/GXG-1829-2022; Tamayo, Aracely/KHU-2891-2024; Adler,
   Nancy/ABR-3334-2022
FU National Institute of Diabetes and Digestive and Kidney Diseases [R01
   DK065664-01-A1, R01 DK080744]; National Institute of Diabetes and
   Digestive and Kidney Diseases [P30DK098722] Funding Source: NIH RePORTER
FX This study was supported by grants from the National Institute of
   Diabetes and Digestive and Kidney Diseases: "Ethnic disparities in
   diabetes complications" (PI Andrew Karter, R01 DK065664-01-A1) and
   "Neighborhood Effects on Weight Change and Diabetes Risk Factors" (PI
   Barbara Laraia, R01 DK080744).
CR [Anonymous], 2014, NAT DIAB STAT REP ES
   Boslaugh SE, 2004, J URBAN HEALTH, V81, P671, DOI 10.1093/jurban/jth150
   Brown BB, 2014, PREV MED, V66, P140, DOI 10.1016/j.ypmed.2014.06.021
   Browning CR, 2002, J HEALTH SOC BEHAV, V43, P383, DOI 10.2307/3090233
   Burdette AM, 2008, SOC SCI MED, V67, P38, DOI 10.1016/j.socscimed.2008.03.029
   Christian H, 2011, PREV MED, V53, P57, DOI 10.1016/j.ypmed.2011.05.004
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   Pham DQ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0105251
   Echeverria SE, 2004, J URBAN HEALTH, V81, P682, DOI 10.1093/jurban/jth151
   Eeg-Olofsson K, 2009, DIABETOLOGIA, V52, P65, DOI 10.1007/s00125-008-1190-x
   Fish JS, 2010, AM J PUBLIC HEALTH, V100, P2296, DOI 10.2105/AJPH.2009.183293
   Gary TL, 2008, DIABETES CARE, V31, P273, DOI 10.2337/dc07-1111
   Grafova IB, 2008, AM J PUBLIC HEALTH, V98, P2065, DOI 10.2105/AJPH.2007.127712
   Jones-Smith JC, 2013, DIABETES CARE, V36, P2697, DOI 10.2337/dc12-2190
   Kerr Z, 2015, PREV MED, V73, P88, DOI 10.1016/j.ypmed.2015.01.017
   Leal C, 2011, OBES REV, V12, P217, DOI 10.1111/j.1467-789X.2010.00726.x
   Lorenc T, 2012, HEALTH PLACE, V18, P757, DOI 10.1016/j.healthplace.2012.04.001
   Loukaitou-Sideris A, 2006, J PLAN LIT, V20, P219, DOI 10.1177/0885412205282770
   McCullagh P., 2019, GEN LINEAR MODELS, DOI DOI 10.1201/9780203753736
   McGinn AP, 2008, J PHYS ACT HEALTH, V5, P117, DOI 10.1123/jpah.5.1.117
   Moffet HH, 2009, INT J EPIDEMIOL, V38, P38, DOI 10.1093/ije/dyn040
   Moreno G, 2014, J COMMUN HEALTH, V39, P1077, DOI 10.1007/s10900-014-9854-6
   Mujahid MS, 2007, AM J EPIDEMIOL, V165, P858, DOI 10.1093/aje/kwm040
   Piro FN, 2006, J EPIDEMIOL COMMUN H, V60, P626, DOI 10.1136/jech.2005.042697
   Powell-Wiley TM, 2013, OBESITY, V21, pE14, DOI 10.1002/oby.20012
   Roux AVD, 2003, J URBAN HEALTH, V80, P569, DOI 10.1093/jurban/jtg065
   Warttig SL, 2013, J HEALTH PSYCHOL, V18, P1617, DOI 10.1177/1359105313508346
   Yelland LN, 2011, AM J EPIDEMIOL, V174, P984, DOI 10.1093/aje/kwr183
   Yen IH, 1999, ANNU REV PUBL HEALTH, V20, P287, DOI 10.1146/annurev.publhealth.20.1.287
   Zou GY, 2004, AM J EPIDEMIOL, V159, P702, DOI 10.1093/aje/kwh090
NR 31
TC 22
Z9 24
U1 0
U2 19
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1353-8292
EI 1873-2054
J9 HEALTH PLACE
JI Health Place
PD MAY
PY 2016
VL 39
BP 116
EP 121
DI 10.1016/j.healthplace.2016.03.007
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA DM7DQ
UT WOS:000376515600015
PM 27060870
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Zeng, Y
   Hua, YQ
   Wang, W
   Zhang, H
   Xu, XL
AF Zeng, Yi
   Hua, Yi Qiao
   Wang, Wei
   Zhang, Hua
   Xu, Xiao Le
TI Modulation of SIRT1-mediated signaling cascades in the liver contributes
   to the amelioration of nonalcoholic steatohepatitis in high fat fed
   middle-aged LDL receptor knockout mice by dihydromyricetin
SO BIOCHEMICAL PHARMACOLOGY
LA English
DT Article
DE Nonalcoholic steatohepatitis; Dihydromyricetin; Metabolic syndrome
ID NF-KAPPA-B; MOUSE MODEL; DISEASE; SIRT1; AMPK; INFLAMMATION;
   RESVERATROL; POLYPHENOLS; METABOLISM; CROSSTALK
AB Dihydromyricetin (DMY) is the most abundant flavonoid in Ampelopsis grossedentata possessing many pharmacological activities. But less is known about its protective effect against nonalcoholic steatohepatitis (NASH) in the context of metabolic syndrome. The present study is aimed to evaluate the pharmacological effects of DMY on NASH induced by feeding a high fat diet to 12-mo-old male LDLr-/- mice for 12 weeks and its molecular mode of action. At the end of the experiment, the blood samples and liver tissues of mice were collected for analysis. The results showed that DMY treatment improved the steatosis, inflammation and fibrosis which are three main aspects of NASH and some of the metabolic basal characteristics. The underlying mechanisms include regulating key regulators of lipid metabolism, oxidative stress, inflammation and fibrosis. Notably, DMY treatment increased hepatic sirtuin 1 (SIRT1) activity and protein expression. DMY also enhanced deacetylation of liver kinase B1 (LKB1) and nuclear transcription factor kappa B (NF-kB). Furthermore, in cultured hepatocyte cells, the benefits of DMY on lipid accumulation, oxidative stress and inflammation as well as the above related genes were abrogated in hepatocytes transfected with SIRT1 siRNA. These results suggest that modulation of SIRT1-mediated signaling cascades contributes to the amelioration of NASH by DMY and DMY may serve as a potential therapeutic candidate for human NASH.
C1 [Zeng, Yi; Hua, Yi Qiao; Wang, Wei; Zhang, Hua; Xu, Xiao Le] Nantong Univ, Dept Pharmacol, Pharm Coll, Nantong 226001, Peoples R China.
   [Wang, Wei] Jiangsu Vocat Coll Med, Yancheng 224005, Peoples R China.
C3 Nantong University; Jiangsu Vocational College of Medicine
RP Xu, XL (corresponding author), Nantong Univ, Dept Pharmacol, Div Med, Med Coll, Nantong 226001, Peoples R China.
EM xiaolexu@ntu.edu.cn
FU National Science Foundation of China [81770446]; Six Talents Peak
   Project of Jiangsu Province [SWYY-022]; Nantong University Cooperative
   Innovation Program of Small Molecular Compound RD [NTU2016-1]
FX The research was supported by the National Science Foundation of China
   (Grant no. 81770446), the Six Talents Peak Project of Jiangsu Province
   (No. SWYY-022) and Nantong University Cooperative Innovation Program of
   Small Molecular Compound R&D (NTU2016-1).
CR Aguirre L, 2014, WORLD J GASTROENTERO, V20, P7366, DOI 10.3748/wjg.v20.i23.7366
   Bieghs V., PLOS ONE, V7
   Cha Ji-Young, 2018, Lab Anim Res, V34, P133, DOI 10.5625/lar.2018.34.4.133
   Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI 10.1002/hep.29367
   Chen SH, 2015, PHARMACOL RES, V99, P74, DOI 10.1016/j.phrs.2015.05.009
   Colak Y, 2014, J GASTROINTEST LIVER, V23, P311, DOI [10.1543/jgld.20l4.1121.233.yck, 10.15403/jgld.2014.1121.233.yck]
   Day EA, 2017, TRENDS ENDOCRIN MET, V28, P545, DOI 10.1016/j.tem.2017.05.004
   Diehl AM, 2017, NEW ENGL J MED, V377, P2063, DOI 10.1056/NEJMra1503519
   Ding RB, 2017, INT J BIOL SCI, V13, P852, DOI 10.7150/ijbs.19370
   Dong SJ, 2019, LIFE SCI, V227, P20, DOI 10.1016/j.lfs.2019.04.019
   Drew L, 2017, NATURE, V550, pS102, DOI 10.1038/550S102a
   Durazzo A, 2019, PHYTOTHER RES, V33, P2221, DOI 10.1002/ptr.6419
   Gottlieb A, 2019, DIGESTION, V100, P79, DOI 10.1159/000493259
   Guclu A, 2016, EXP CLIN ENDOCR DIAB, V124, P131, DOI 10.1055/s-0035-1565067
   Guo L, 2019, MOL MED REP, V19, P1638, DOI 10.3892/mmr.2018.9783
   Gupte AA, 2014, ENDOCRINOLOGY, V155, P4697, DOI 10.1210/en.2014-1430
   Gupte AA, 2010, HEPATOLOGY, V52, P2001, DOI 10.1002/hep.23941
   Ikejima K, 2005, HEPATOL RES, V33, P151, DOI 10.1016/j.hepres.2005.09.024
   Joo MS, 2016, MOL CELL BIOL, V36, P1931, DOI 10.1128/MCB.00118-16
   Kauppinen A, 2013, CELL SIGNAL, V25, P1939, DOI 10.1016/j.cellsig.2013.06.007
   Kessoku T, 2016, SCI REP-UK, V6, DOI 10.1038/srep22251
   Lan F, 2008, J BIOL CHEM, V283, P27628, DOI 10.1074/jbc.M805711200
   Lee WJ, 2006, BIOCHEM BIOPH RES CO, V340, P291, DOI 10.1016/j.bbrc.2005.12.011
   Liu TT, 2017, ATHEROSCLEROSIS, V262, P39, DOI 10.1016/j.atherosclerosis.2017.05.003
   Mohan SK, 2015, IRAN J BASIC MED SCI, V18, P832
   Peng S, 2019, PHYTOMEDICINE, V61, DOI 10.1016/j.phymed.2019.152989
   Qiu P, 2017, TOXICOL LETT, V274, P31, DOI 10.1016/j.toxlet.2017.04.009
   Rao Y, 2019, BRIT J PHARMACOL, V176, P2877, DOI 10.1111/bph.14713
   Rinella ME, 2004, J HEPATOL, V40, P47, DOI 10.1016/j.jhep.2003.09.020
   Saadati S, 2019, BMC GASTROENTEROL, V19, DOI 10.1186/s12876-019-1055-4
   Salomone F, 2016, LIVER INT, V36, P5, DOI 10.1111/liv.12975
   Tang K, 2018, EUR J PHARMACOL, V830, P76, DOI 10.1016/j.ejphar.2018.04.026
   Wang Q, 2018, BIOL PHARM BULL, V41, P985, DOI 10.1248/bpb.b17-00724
   Wardyn JD, 2015, BIOCHEM SOC T, V43, P621, DOI 10.1042/BST20150014
   Wegermann Kara, 2018, Clin Liver Dis (Hoboken), V11, P87, DOI 10.1002/cld.709
   Xie J, 2015, WORLD J GASTROENTERO, V21, P5473, DOI 10.3748/wjg.v21.i18.5473
   Xu J., 2019, INT J MOL SCI, V20
   Zeng XL, 2019, ANTIOXID REDOX SIGN, V30, P163, DOI 10.1089/ars.2017.7172
   Zeng Y, 2018, BIOMED PHARMACOTHER, V101, P543, DOI 10.1016/j.biopha.2018.02.124
   Zhang JY, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01204
NR 40
TC 40
Z9 41
U1 2
U2 31
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0006-2952
EI 1873-2968
J9 BIOCHEM PHARMACOL
JI Biochem. Pharmacol.
PD MAY
PY 2020
VL 175
AR 113927
DI 10.1016/j.bcp.2020.113927
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA LF3WF
UT WOS:000527350300044
PM 32217100
DA 2025-06-11
ER

PT J
AU Mallard, AR
   Ramos, JS
   Roberts, LA
   Centner, CM
   Fassett, RG
   Coombes, JS
AF Mallard, Alistair R.
   Ramos, Joyce S.
   Roberts, Llion A.
   Centner, Christoph M.
   Fassett, Robert G.
   Coombes, Jeff S.
TI The association between metabolic syndrome severity and oxidative stress
   induced by maximal exercise testing - a cross-sectional study
SO BIOMARKERS
LA English
DT Article
DE F2-isoprostanes; protein carbonyls; antioxidants; cardiorespiratory
   fitness; exercise
ID HOMEOSTASIS; BIOMARKERS; PLASMA; BLOOD; MODEL
AB Purpose: Oxidative stress (OS) has been implicated in the pathogenesis of metabolic syndrome (MetS). The acute change in OS biomarkers due to exercise, known as exercise-induced OS (EIOS), is postulated to be a more appropriate marker of OS compared to spot OS measures. These studies objectives were to investigate EIOS in participants with MetS and compare the associations between EIOS, spot OS measures and MetS severity.Methods: Sixty-three participants with MetS had MetS severity assessed using the MetS Z-score. Participants undertook a cardiorespiratory fitness test (O(2)peak) to volitional exhaustion (approximate to 8-12 minutes). Plasma OS (total F2-isoprostanes (IsoP), protein carbonyls (PCs)) and antioxidant (glutathione peroxidase (GPx), total antioxidant status (TAS)) biomarkers were measured from samples obtained before and fiveminutes post-O(2)peak test. Wilcoxon's signed-rank tests were used to determine changes in OS markers.Results: There were no significant (p>0.05) changes in OS or antioxidant biomarkers from pre- to post-exercise (median (interquartile range): IsoP -15.5 (-71.8 to 47.8) pg/mL; PC -0.01 (-0.16 to 0.13) nmol/mg protein; GPx 0.76 (-4.94 to 9.82) U/L, TAS 0.03 (0.00-0.05) mmol/L).Conclusions: A O(2)peak test to exhaustion failed to induce OS in participants with MetS. There were no associations between MetS severity and spot OS or EIOS biomarkers.
C1 [Mallard, Alistair R.; Roberts, Llion A.; Fassett, Robert G.; Coombes, Jeff S.] Univ Queensland, Ctr Res Exercise Phys Act & Hlth, Sch Human Movement Studies, Brisbane, Qld, Australia.
   [Ramos, Joyce S.] Flinders Univ S Australia, Coll Nursing & Hlth Sci, Dept Hlth & Exercise Sci, Adelaide, SA, Australia.
   [Centner, Christoph M.] Univ Freiburg, Dept Sport Sci, Freiburg, Germany.
C3 University of Queensland; Flinders University South Australia;
   University of Freiburg
RP Mallard, AR (corresponding author), Univ Queensland, Sch Human Movement & Nutr Sci, Ctr Res Exercise Phys Act & Hlth, Brisbane, Qld 4072, Australia.
EM a.mallard@uq.edu.au
RI Centner, Christoph/L-6926-2019; Fassett, Robert/R-3495-2019; Roberts,
   Llion/AAF-9393-2020; Mallard, Alistair/AAD-1147-2019; Roberts,
   Llion/E-6593-2012; Mallard, Alistair/H-4570-2014
OI Ramos, Joyce/0000-0001-8693-6800; Centner,
   Christoph/0000-0001-6839-4438; Roberts, Llion/0000-0002-2284-1033;
   Mallard, Alistair/0000-0002-7961-1458
FU Coca-Cola company
FX This study was funded by an unrestricted research grant from the from
   the Coca-Cola company. The funders had no role in the design and conduct
   of the study.
CR Briskey DR, 2014, J PHARMACEUT BIOMED, V90, P161, DOI 10.1016/j.jpba.2013.11.028
   Done AJ, 2017, FREE RADICAL RES, V51, P646, DOI 10.1080/10715762.2017.1353689
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Laaksonen DE, 1996, DIABETES CARE, V19, P569, DOI 10.2337/diacare.19.6.569
   LEVINE RL, 1990, METHOD ENZYMOL, V186, P464
   Malin SK, 2014, METAB SYNDR RELAT D, V12, P79, DOI 10.1089/met.2013.0083
   Margaritelis NV, 2016, FREE RADICAL BIO MED, V98, P2, DOI 10.1016/j.freeradbiomed.2016.02.005
   Margaritelis N.V., 2017, ACTA PHYSL OXFORD, V222
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mullins AL, 2013, BIOMARKERS, V18, P446, DOI 10.3109/1354750X.2013.810668
   Nikolaidis MG, 2012, BIOMARKERS, V17, P28, DOI 10.3109/1354750X.2011.635805
   Radak Z, 2017, REDOX BIOL, V12, P285, DOI 10.1016/j.redox.2017.02.015
   RICEEVANS C, 1994, METHOD ENZYMOL, V234, P279
   Shashaj B, 2016, ACTA DIABETOL, V53, P251, DOI 10.1007/s00592-015-0782-4
   Stagos D, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/204615
   Tjonna AE, 2018, BMC PUBLIC HEALTH, V18, DOI 10.1186/s12889-018-5343-7
   Tucker PS, 2008, CURR DIABETES REV, V4, P309, DOI 10.2174/157339908786241160
   van 't Erve TJ, 2017, REDOX BIOL, V12, P582, DOI 10.1016/j.redox.2017.03.024
   Whaley-Connell A, 2011, REV CARDIOVASC MED, V12, P21, DOI 10.3909/ricm0555
   WHEELER CR, 1990, ANAL BIOCHEM, V184, P193, DOI 10.1016/0003-2697(90)90668-Y
   Wild SH, 2011, METABOLIC SYNDROME, 2ND EDITION, P1
NR 22
TC 3
Z9 3
U1 0
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1354-750X
EI 1366-5804
J9 BIOMARKERS
JI Biomarkers
PD MAY 19
PY 2019
VL 24
IS 4
BP 394
EP 400
DI 10.1080/1354750X.2019.1600022
PG 7
WC Biotechnology & Applied Microbiology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Toxicology
GA ID9BH
UT WOS:000471981900011
PM 30907677
DA 2025-06-11
ER

PT J
AU Wysokinski, A
AF Wysokinski, Adam
TI Fasting Serum Levels of Neuropeptide Y in Patients With Schizophrenia on
   Clozapine Monotherapy
SO CLINICAL NEUROPHARMACOLOGY
LA English
DT Review
DE schizophrenia; clozapine; NPY; metabolic syndrome
ID CORTICOTROPIN-RELEASING HORMONE; X-RAY ABSORPTIOMETRY; WEIGHT-GAIN;
   ATYPICAL ANTIPSYCHOTICS; CEREBROSPINAL-FLUID; METABOLIC SYNDROME;
   BODY-COMPOSITION; INDUCED OBESITY; DEPRESSION; GHRELIN
AB Objective: Neuropeptide Y (NPY) is one of the hypothalamic hormones that works by increasing appetite and decreasing metabolism, leading to weight gain. We checked whether NPY level in subjects with schizophrenia on clozapine is higher compared with healthy controls.
   Methods: We determined the fasting NPY levels of 24 subjects with schizophrenia on clozapine monotherapy and 24 age-and sex-matched healthy controls.
   Results: There was no difference for NPY between the clozapine group and the control group (mean [SD], 323.33 [138.50] vs 295.83 [25.28] pg/mL, P = 0.25). Neuropeptide Y was higher in women in the clozapine group (376.00 [162.15] vs 275.45 [96.99] pg/mL, P = 0.048) but not in the control group (P = 0.31) or in the whole study group (P = 0.20). We found no correlations between NPY and age, weight, body mass index, fat mass index, body circumferences, blood pressure, waist-to-hip ratio, levels of cholesterol, high-density lipoproteins, low-density lipoproteins, triglycerides, uric acid, calcium, homocysteine, glucose, insulin, insulin resistance, treatment duration, dose of clozapine, body composition, or basal metabolic rate.
   Conclusions: We cannot conclude that treatment with clozapine is associated with increased level of NPY. We did not find previously described differences in NPY for obesity or associations between NPY and metabolic parameters.
C1 Med Univ Lodz, Dept Old Age Psychiat & Psychot Disorders, PL-92216 Lodz, Poland.
C3 Medical University Lodz
RP Wysokinski, A (corresponding author), Med Univ Lodz, Dept Old Age Psychiat & Psychot Disorders, Czechoslowacka 8-10, PL-92216 Lodz, Poland.
EM adam.wysokinski@gmail.com
RI Wysokinski, Adam/S-9294-2016; Wysokinski, Adam/G-8174-2014
OI Wysokinski, Adam/0000-0002-6159-6579
FU Healthy Ageing Research Centre [REGPOT-2012-2013-1]
FX Conflicts of Interest and Source of Funding: The author is partially
   supported by Healthy Ageing Research Centre (REGPOT-2012-2013-1, 7FP).
   The author has no conflicts of interest to declare.
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Andrews ZB, 2011, PEPTIDES, V32, P2248, DOI 10.1016/j.peptides.2011.05.014
   Aydin K, 2005, J CHILD NEUROL, V20, P848, DOI 10.1177/08830738050200101501
   Bachmann CJ, 2012, Z KINDER JUG-PSYCH, V40, P151, DOI 10.1024/1422-4917/a000165
   Baltazi M, 2011, AM J CARDIOVASC DIS, V1, P48
   Bjornebekk A, 2006, NEUROPSYCHOPHARMACOL, V31, P256, DOI 10.1038/sj.npp.1300820
   Bosy-Westphal A, 2008, OBESITY FACTS, V1, P319, DOI 10.1159/000176061
   Briggs DI, 2010, ENDOCRINOLOGY, V151, P4745, DOI 10.1210/en.2010-0556
   Dipasquale S, 2013, J PSYCHIATR RES, V47, P197, DOI 10.1016/j.jpsychires.2012.10.005
   Druce MR, 2004, ENDOCRINOLOGY, V145, P2660, DOI 10.1210/en.2004-0089
   Eaton K, 2007, CURR TOP MED CHEM, V7, P1645, DOI 10.2174/156802607782341037
   EGAWA M, 1990, NEUROSCIENCE, V34, P771, DOI 10.1016/0306-4522(90)90181-3
   Ferno J, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020571
   Fontaine KR, 2001, PSYCHIAT RES, V101, P277, DOI 10.1016/S0165-1781(01)00234-7
   Hagan MM, 2000, AM J PHYSIOL-REG I, V279, pR47, DOI 10.1152/ajpregu.2000.279.1.R47
   Kane John M, 2012, J Clin Psychiatry, V73, pe07, DOI 10.4088/JCP.11076tx2c
   Kelly TL, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007038
   Kroeze WK, 2003, NEUROPSYCHOPHARMACOL, V28, P519, DOI 10.1038/sj.npp.1300027
   Kuo LE, 2007, NAT MED, V13, P803, DOI 10.1038/nm1611
   Morton GJ, 2001, INT J OBESITY, V25, pS56, DOI 10.1038/sj.ijo.0801915
   Newcomer JW, 2005, CNS DRUGS, V19, P1
   Nikisch G, 2012, INT J NEUROPSYCHOPH, V15, P1051, DOI 10.1017/S1461145711001556
   SAHU A, 1988, PEPTIDES, V9, P83, DOI 10.1016/0196-9781(88)90013-7
   Schwartz MW, 2000, NATURE, V404, P661, DOI 10.1038/35007534
   Sentissi O, 2008, SCHIZOPHRENIA BULL, V34, P1189, DOI 10.1093/schbul/sbm141
   Tiihonen J, 2009, LANCET, V374, P620, DOI 10.1016/S0140-6736(09)60742-X
   Wetterling T, 2001, DRUG SAFETY, V24, P59, DOI 10.2165/00002018-200124010-00005
   WIDERLOV E, 1988, J PSYCHIATR RES, V22, P69, DOI 10.1016/0022-3956(88)90030-1
   Wysokinski A, 2014, PHARMACOPSYCHIATRY, V47, P169, DOI 10.1055/s-0034-1382012
   Yanik T, 2013, J CLIN PSYCHOPHARM, V33, P608, DOI 10.1097/JCP.0b013e318297980e
   Yoshida-Komiya H, 2014, PSYCHIAT CLIN NEUROS, V68, P574, DOI 10.1111/pcn.12160
NR 31
TC 6
Z9 6
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0362-5664
EI 1537-162X
J9 CLIN NEUROPHARMACOL
JI Clin. Neuropharmacol.
PD JAN-FEB
PY 2015
VL 38
IS 1
BP 18
EP 22
DI 10.1097/WNF.0000000000000062
PG 5
WC Clinical Neurology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA AZ3SK
UT WOS:000348146800004
PM 25580919
DA 2025-06-11
ER

PT J
AU Rönngren, Y
   Björk, A
   Haage, D
   Audulv, A
AF Ronngren, Ylva
   Bjork, Annette
   Haage, David
   Audulv, Asa
TI Initiating and Maintaining a Lifestyle Program Directed at Persons
   Living with Severe Mental Illness in a Municipality Care Setting
SO ISSUES IN MENTAL HEALTH NURSING
LA English
DT Article
ID PHYSICAL-ACTIVITY; METABOLIC SYNDROME; EXCESS MORTALITY; HEALTH
   LITERACY; PEOPLE; INTERVENTIONS; DISORDERS; FRAMEWORK; BURDEN; REDUCE
AB Lifestyle programs are effective in improving the health of persons living with severe mental illness. However, the implementation of these programs and making them a sustainable part of daily care remain challenging. This qualitative descriptive study aimed to describe how staff worked with and experienced a lifestyle program in a municipality mental health care setting over time. The program intended to support persons living with severe mental illness to overcome health challenges. Data was collected at three time points spanning 7 years. The staff motivated the participants with SMI with severe mental illness to take part in the program, prepared them, and gave them individualized lifestyle support. A key factor of the program's implementation was the staff's interest and engagement in lifestyle questions. According to the staff it was apparent that small efforts such as running the present program could give synergic health effects such as improved mental- and social health. This study shows that it is feasible to conduct this lifestyle program in ordinary care without considerable resources. However, support from management is crucial, as well as the development of guidelines and routines of the work with lifestyle questions.
C1 [Ronngren, Ylva; Bjork, Annette; Haage, David] Mid Sweden Univ, Dept Hlth Sci, Sundsvall, Sweden.
   [Audulv, Asa] Umea Univ, Dept Nursing, Umea, Sweden.
C3 Mid-Sweden University; Umea University
RP Rönngren, Y (corresponding author), Mid Sweden Univ, Dept Hlth Sci, Sundsvall, Sweden.
EM Ylva.ronngren@miun.se
RI Audulv, Åsa K/HJO-9269-2023
OI Ronngren, Ylva/0000-0002-0002-7866
CR Alexander GL, 2018, HEALTH EDUC BEHAV, V45, P492, DOI 10.1177/1090198117736347
   Almeida OP, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0111882
   [Anonymous], 2016, LANCET, V387, P1027, DOI 10.1016/S0140-6736(16)00687-5
   Audulv Å, 2023, BMC MED RES METHODOL, V23, DOI 10.1186/s12874-023-02105-1
   Bartels SJ, 2018, PSYCHIAT SERV, V69, P664, DOI 10.1176/appi.ps.201700368
   Berkman ND, 2011, ANN INTERN MED, V155, P97, DOI 10.7326/0003-4819-155-2-201107190-00005
   Brainard J, 2016, BMC HEALTH SERV RES, V16, DOI 10.1186/s12913-016-1479-2
   Damschroder LJ, 2022, IMPLEMENT SCI, V17, DOI [10.1186/s13012-021-01181-5, 10.1186/s13012-022-01245-0]
   Deenik J, 2019, BMC HEALTH SERV RES, V19, DOI 10.1186/s12913-019-4608-x
   Deenik J, 2020, TRANSL BEHAV MED, V10, P1070, DOI 10.1093/tbm/ibz067
   Deenik J, 2017, BMC PSYCHIATRY, V17, DOI 10.1186/s12888-017-1466-0
   Degan TJ, 2019, PSYCHIAT RES, V280, DOI 10.1016/j.psychres.2019.112499
   Farrell SJ, 2020, COMMUNITY MENT HLT J, V56, P645, DOI 10.1007/s10597-019-00525-2
   Fletcher GF, 2018, J AM COLL CARDIOL, V72, P1622, DOI 10.1016/j.jacc.2018.08.2141
   Fortuna KL, 2021, PSYCHIAT QUART, V92, P101, DOI 10.1007/s11126-020-09777-8
   Grossoehme Daniel, 2016, BMC Res Notes, V9, P136, DOI 10.1186/s13104-016-1954-1
   Hawes MR, 2022, HEALTH SOC CARE COMM, V30, pE2989, DOI 10.1111/hsc.13744
   Heinberg LJ, 2021, CURR OBES REP, V10, P365, DOI 10.1007/s13679-021-00447-9
   Jager M, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16214300
   Kalinowska S, 2021, J CLIN MED, V10, DOI 10.3390/jcm10010165
   Lawrence D, 2010, CAN J PSYCHIAT, V55, P752, DOI 10.1177/070674371005501202
   Liu NH, 2017, WORLD PSYCHIATRY, V16, P30, DOI 10.1002/wps.20384
   Lopuszanska UJ, 2014, ANN AGR ENV MED, V21, P815, DOI 10.5604/12321966.1129939
   Lund K, 2019, SCAND J OCCUP THER, V26, P55, DOI 10.1080/11038128.2017.1409266
   Lundström S, 2020, INT J MENT HEALTH NU, V29, P244, DOI 10.1111/inm.12669
   Malterud K, 2016, QUAL HEALTH RES, V26, P1753, DOI 10.1177/1049732315617444
   Manger S, 2019, AUST J GEN PRACT, V48, P670, DOI 10.31128/AJGP-06-19-4964
   Mantwill S, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0145455
   Mathieson A, 2018, PRIM HEALTH CARE RES, V20, DOI 10.1017/S1463423618000488
   Molina JD, 2021, CURR PHARM DESIGN, V27, P4049, DOI 10.2174/1381612827666210804110139
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Plana-Ripoll O, 2019, JAMA PSYCHIAT, V76, P259, DOI 10.1001/jamapsychiatry.2018.3658
   Richards L, 2016, J PSYCHOSOC NURS MEN, V54, P46, DOI 10.3928/02793695-20151109-02
   Rönngren YM, 2014, J PSYCHIATR MENT HLT, V21, P924, DOI 10.1111/jpm.12175
   Rönngren Y, 2018, INT J MENT HEALTH NU, V27, P1022, DOI 10.1111/inm.12410
   Rönngren Y, 2018, PERSPECT PSYCHIATR C, V54, P309, DOI 10.1111/ppc.12239
   Rosenbaum S, 2014, J CLIN PSYCHIAT, V75, P964, DOI 10.4088/JCP.13r08765
   Ruser CB, 2005, POSTGRAD MED, V117, P31, DOI 10.3810/pgm.2005.01.1568
   Sandelowski M, 2000, RES NURS HEALTH, V23, P334, DOI 10.1002/1098-240X(200008)23:4<334::AID-NUR9>3.0.CO;2-G
   Scott David, 2011, Issues Ment Health Nurs, V32, P589, DOI 10.3109/01612840.2011.569846
   Speyer H, 2019, PSYCHOTHER PSYCHOSOM, V88, P350, DOI 10.1159/000502293
   Suetani S, 2016, EPIDEMIOL PSYCH SCI, V25, P205, DOI 10.1017/S2045796015001043
   Suetani S, 2017, SOC PSYCH PSYCH EPID, V52, P795, DOI 10.1007/s00127-016-1307-3
   Tjörnstrand C, 2020, BMC PSYCHIATRY, V20, DOI 10.1186/s12888-020-02896-3
   Vancampfort D, 2016, J AFFECT DISORDERS, V201, P145, DOI 10.1016/j.jad.2016.05.020
   Walburg F, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0271990
   Walburg FS, 2022, BMC HEALTH SERV RES, V22, DOI 10.1186/s12913-021-07391-3
   Weman-Josefsson K, 2015, INT J BEHAV NUTR PHY, V12, DOI 10.1186/s12966-015-0226-0
   World Med Assoc, 2013, JAMA-J AM MED ASSOC, V310, P2191, DOI 10.1001/jama.2013.281053
   Yalçin SU, 2019, ISSUES MENT HEALTH N, V40, P908, DOI 10.1080/01612840.2019.1619201
NR 50
TC 1
Z9 1
U1 0
U2 0
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0161-2840
EI 1096-4673
J9 ISSUES MENT HEALTH N
JI Issues Ment. Health Nurs.
PD JUL 2
PY 2024
VL 45
IS 7
BP 706
EP 714
DI 10.1080/01612840.2024.2344805
EA APR 2024
PG 9
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA YL7T9
UT WOS:001216417000001
PM 38717866
OA hybrid
DA 2025-06-11
ER

PT J
AU Barbhuiya, PA
   Pathak, MP
AF Barbhuiya, Pervej Alom
   Pathak, Manash Pratim
TI Impact of Obesity, Menopause, and Depression in Women's Health:An
   Attempt to Decipher the Complex Relationship
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review; Early Access
DE Obesity; menopause; depression; estrogen; women's health; phytoestrogens
ID GENOME-WIDE ASSOCIATION; BODY-MASS INDEX; POSTMENOPAUSAL WOMEN; HOT
   FLASHES; VISCERAL FAT; REPRODUCTIVE HORMONES; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; ADIPOSE-TISSUE; MIDLIFE WOMEN
AB Background: Menopause symptoms may be distressing, especially when they appear at a time when women are expected to play significant responsibilities in society. Numerous biological systems are influenced by the hormonal changes that start during the menopausal transition. This review attempts to decipher the complex relationship between obesity, menopause, and depression, citing some recent longitudinal and cross-sectional studies. Additionally, this study provides a summary of the different phytoestrogens, their sources, and probable mechanisms of action in addition to available therapeutic alternatives. Methodology: For this review purpose, the authors have gone through a vast number of articles from various scientific databases like PubMed, Google Scholar, and Web of Science. Results: It is becoming clear that the physiological basis for these menopausal symptoms is complicated and connected to estrogen deficiency, but not alone. Other hormones like FSH, LH, progesterone, and inhibin B are the major ones that are both directly and indirectly responsible for most of the menopausal symptoms. Numerous longitudinal and cross-sectional studies have found a direct relationship between the incidence of menopause and depression as well as obesity. Phytoestrogens like stilbene, lignans, isoflavone, and coumestan have been reported to be the alternatives to synthetic estrogen with lesser side effects, as reported in various studies. Conclusion: The complex relationship between depression, menopause, and obesity presents a complex obstacle to women's health and overall well-being. There might be a lot of promising prospects for revolutionary advancements in women's health during the menopausal stage in the future. Promising drug development that targets not just one but also the three conditions -obesity, menopause, and depression - as well as more thorough research are needed to improve the healthcare system for women who suffer from these conditions.
C1 [Barbhuiya, Pervej Alom; Pathak, Manash Pratim] Assam Down Town Univ, Fac Pharmaceut Sci, Sankar Madhab Path, Gauhati 781026, Assam, India.
   [Barbhuiya, Pervej Alom; Pathak, Manash Pratim] Assam Down Town Univ, Ctr Res Ethnomed, Sankar Madhab Path, Gauhati 781026, Assam, India.
C3 Assam Down Town University; Assam Down Town University
RP Pathak, MP (corresponding author), Assam Down Town Univ, Fac Pharmaceut Sci, Sankar Madhab Path, Gauhati 781026, Assam, India.
EM manashpharma@rediffmail.com
RI Pathak, Manash/I-3539-2019
FU Assam down town University, Guwahati, India [AdtU/DRA-II/2023-24/156]
FX The authors are thankful to Assam down town University, Guwahati, India,
   for providing financial support in the form of a Seed Money Grant vide
   award letter number AdtU/DRA-II/2023-24/156.
CR Akiyama M, 2017, NAT GENET, V49, P1458, DOI 10.1038/ng.3951
   Al-Akoum M, 2009, MENOPAUSE, V16, P307, DOI 10.1097/gme.0b013e31818572a0
   Al-Safi ZA, 2015, BEST PRACT RES CL OB, V29, P548, DOI 10.1016/j.bpobgyn.2014.12.002
   Albert S, 2011, BIOORGAN MED CHEM, V19, P5155, DOI 10.1016/j.bmc.2011.07.015
   Atasoy S, 2018, J PSYCHOSOM RES, V115, P66, DOI 10.1016/j.jpsychores.2018.10.007
   Azizi M, 2022, IRAN J MED SCI, V47, P173, DOI 10.30476/ijms.2020.87687.1817
   Bansal R, 2019, J MID-LIFE HEALTH, V10, P6, DOI 10.4103/jmh.JMH_7_19
   Barbhuiya PA, 2024, PHYTOCHEM REV, V23, P969, DOI 10.1007/s11101-023-09912-w
   Bedell S, 2014, J STEROID BIOCHEM, V139, P225, DOI 10.1016/j.jsbmb.2012.12.004
   Bhathena SJ, 2002, AM J CLIN NUTR, V76, P1191, DOI 10.1093/ajcn/76.6.1191
   Blümel JE, 2016, MENOPAUSE, V23, P488, DOI 10.1097/GME.0000000000000575
   Bromberger JT, 2007, J AFFECT DISORDERS, V103, P267, DOI 10.1016/j.jad.2007.01.034
   Bromberger JT, 2018, OBSTET GYN CLIN N AM, V45, P663, DOI 10.1016/j.ogc.2018.07.007
   CalvoFlores FG, 2015, LIGNIN AND LIGNANS AS RENEWABLE RAW MATERIALS: CHEMISTRY, TECHNOLOGY AND APPLICATIONS, P1, DOI 10.1002/9781118682784
   Caretto M., 2020, Obesity and Gynecology, P273, DOI [10.1016/B978-0-12-817919-2.00030-9, DOI 10.1016/B978-0-12-817919-2.00030-9]
   Carranza-Lira S, 1999, INT J GYNECOL OBSTET, V65, P35, DOI 10.1016/S0020-7292(99)00017-X
   Chao PY, 2017, INT J MED SCI, V14, P896, DOI 10.7150/ijms.19933
   Chedraui P, 2008, GYNECOL ENDOCRINOL, V24, P620, DOI 10.1080/09513590802288283
   Cheng K., 2023, Extracell Vesicle, V2, P100029, DOI [DOI 10.1016/J.VESIC.2023.100029, 10.1016/j.vesic.2023.100029]
   Chopra S, 2019, J MID-LIFE HEALTH, V10, P165, DOI 10.4103/jmh.JMH_155_19
   Chrzastek Z, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020515
   Cooke PS, 2004, EXP BIOL MED, V229, P1127, DOI 10.1177/153537020422901107
   Dat NT, 2005, CHEM PHARM BULL, V53, P114, DOI 10.1248/cpb.53.114
   Davis SR, 2012, CLIMACTERIC, V15, P419, DOI 10.3109/13697137.2012.707385
   Davis SR, 2015, NAT REV DIS PRIMERS, V1, DOI 10.1038/nrdp.2015.4
   Desmawati Desmawati, 2019, Open Access Maced J Med Sci, V7, P495, DOI 10.3889/oamjms.2019.044
   Dong C, 2004, INT J OBESITY, V28, P790, DOI 10.1038/sj.ijo.0802626
   DUKER EM, 1991, PLANTA MED, V57, P420, DOI 10.1055/s-2006-960139
   Ehsanpour Soheila, 2012, Iran J Nurs Midwifery Res, V17, P34
   El Khoudary SR, 2019, MENOPAUSE, V26, P1213, DOI 10.1097/GME.0000000000001424
   Elsabagh S, 2005, J PSYCHOPHARMACOL, V19, P173, DOI 10.1177/0269881105049038
   Ferrari G, 2022, BMC PEDIATR, V22, DOI 10.1186/s12887-022-03577-8
   Finucane HK, 2015, NAT GENET, V47, P1228, DOI 10.1038/ng.3404
   Flegal KM, 2010, JAMA-J AM MED ASSOC, V303, P235, DOI 10.1001/jama.2009.2014
   Franco OH, 2016, JAMA-J AM MED ASSOC, V315, P2554, DOI 10.1001/jama.2016.8012
   Freedman RR, 2005, AM J MED, V118, P1410, DOI 10.1016/j.amjmed.2005.10.022
   Freeman EW, 2007, OBSTET GYNECOL, V110, P230, DOI 10.1097/01.AOG.0000270153.59102.40
   Freeman EW, 2010, MENOPAUSE, V17, P823, DOI 10.1097/gme.0b013e3181db9f8b
   Freeman EW, 2006, ARCH GEN PSYCHIAT, V63, P375, DOI 10.1001/archpsyc.63.4.375
   Freeman EW, 2004, ARCH GEN PSYCHIAT, V61, P62, DOI 10.1001/archpsyc.61.1.62
   Gao X, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.633447
   Geiselman PJ, 2006, SCIENTIFIC EVIDENCE FOR MUSCULOSKELETAL, BARIATRIC, AND SPORTS NUTRITION, P231
   George ES, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19074399
   Gibson CJ, 2013, INT J OBESITY, V37, P809, DOI 10.1038/ijo.2012.164
   Goetz LH, 2018, FERTIL STERIL, V109, P952, DOI 10.1016/j.fertnstert.2018.05.006
   Gordon JL, 2016, MENOPAUSE, V23, P1189, DOI 10.1097/GME.0000000000000689
   Haddad F, 2023, LIFE-BASEL, V13, DOI 10.3390/life13041012
   Halbreich U, 2000, ARCH GEN PSYCHIAT, V57, P1163, DOI 10.1001/archpsyc.57.12.1163
   Harlow SD, 2012, MENOPAUSE, V19, P387, DOI 10.1097/gme.0b013e31824d8f40
   He Y, 2022, J PSYCHOSOM RES, V163, DOI 10.1016/j.jpsychores.2022.111049
   Heidari Mohammad, 2017, J Menopausal Med, V23, P42, DOI 10.6118/jmm.2017.23.1.42
   Herson M, 2022, DRUG AGING, V39, P607, DOI 10.1007/s40266-022-00962-x
   Ho SC, 2017, MENOPAUSE, V24, P180, DOI 10.1097/GME.0000000000000734
   Hryhorczuk C, 2013, FRONT NEUROSCI-SWITZ, V7, DOI 10.3389/fnins.2013.00177
   Ibrahim RM, 2014, ADV PHARM BULL, V4, P29, DOI 10.5681/apb.2014.005
   Janssen I, 2010, OBESITY, V18, P604, DOI 10.1038/oby.2009.251
   Jantaratnotai N, 2017, OBES RES CLIN PRACT, V11, P1, DOI 10.1016/j.orcp.2016.07.003
   Jokela M, 2023, J PSYCHIATR RES, V163, P86, DOI 10.1016/j.jpsychires.2023.05.034
   Kanaley JA, 2001, METABOLISM, V50, P976, DOI 10.1053/meta.2001.24931
   Kanaley JA, 2003, METABOLISM, V52, P186, DOI 10.1053/meta.2003.50024
   Karvonen-Gutierrez C, 2016, HEALTHCARE-BASEL, V4, DOI 10.3390/healthcare4030042
   Kaul K, 2013, ADV EXP MED BIOL, V771, P1
   Kim HJ, 2019, J FUNCT FOODS, V57, P453, DOI 10.1016/j.jff.2019.03.051
   Kim MH, 2017, AM J CHINESE MED, V45, P269, DOI [10.1142/S0192415X17500173, 10.1142/s0192415x17500173]
   Kiyama R, 2023, J NUTR BIOCHEM, V114, DOI 10.1016/j.jnutbio.2022.109250
   Kozakowski J, 2017, MENOPAUSE REV, V16, P61, DOI 10.5114/pm.2017.68594
   Kravitz HM, 2005, ARCH INTERN MED, V165, P2370, DOI 10.1001/archinte.165.20.2370
   Kulkarni J, 2022, NATURE, V608, pS54, DOI 10.1038/d41586-022-02213-w
   Kurita K, 2016, FERTIL STERIL, V106, P749, DOI 10.1016/j.fertnstert.2016.04.033
   Labrie F, 1997, J CLIN ENDOCR METAB, V82, P2403, DOI 10.1210/jc.82.8.2403
   Lei ZL, 2022, INT J FOOD SCI TECH, V57, P1451, DOI 10.1111/ijfs.15507
   Li X, 2023, NAT COMMUN, V14, DOI 10.1038/s41467-023-38684-2
   Liu S, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-27044-7
   Locke AE, 2015, NATURE, V518, P197, DOI 10.1038/nature14177
   Lovejoy JC, 2008, INT J OBESITY, V32, P949, DOI 10.1038/ijo.2008.25
   Mahdavipour F, 2019, COMPLEMENT THER MED, V47, DOI 10.1016/j.ctim.2019.102195
   Malmir H, 2019, DIABETES METAB SYND, V13, P1099, DOI 10.1016/j.dsx.2019.01.027
   Maru G.B., 2014, Polyphenols in Human Health and Disease, P1141, DOI [DOI 10.1016/B978-0-12-398456-2.00088-8, 10.1016/B978-0-12-3984562.00088-8, DOI 10.1016/B978-0-12-3984562.00088-8]
   Mauvais-Jarvis F, 2013, ENDOCR REV, V34, P309, DOI 10.1210/er.2012-1055
   Mirabi P, 2013, IRAN J PHARM RES, V12, P217
   Monteleone P, 2018, NAT REV ENDOCRINOL, V14, P199, DOI 10.1038/nrendo.2017.180
   Morrison MF, 2001, BIOL PSYCHIAT, V50, P705, DOI 10.1016/S0006-3223(01)01169-6
   Muharam R, 2018, MIDDLE EAST FERTIL S, V23, P27, DOI 10.1016/j.mefs.2017.08.003
   Murphy JM, 2009, INT J OBESITY, V33, P335, DOI 10.1038/ijo.2008.273
   Nagula RL, 2019, J CONTROL RELEASE, V296, P190, DOI 10.1016/j.jconrel.2019.01.029
   Nahidi F, 2012, IRAN J PHARM RES, V11, P1079
   Opoku AA, 2023, BEST PRACT RES CL OB, V88, DOI 10.1016/j.bpobgyn.2023.102348
   Park E, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020369
   Park H, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15112327
   Patsalos O, 2021, J PERS MED, V11, DOI 10.3390/jpm11030176
   Pedersen SB, 2004, J CLIN ENDOCR METAB, V89, P1869, DOI 10.1210/jc.2003-031327
   Plackett B, 2022, NATURE, V608, pS42, DOI 10.1038/d41586-022-02207-8
   Power RA, 2017, BIOL PSYCHIAT, V81, P325, DOI 10.1016/j.biopsych.2016.05.010
   Rabiei Samira, 2023, Clinical Nutrition Open Science, V47, P44, DOI 10.1016/j.nutos.2022.11.005
   Rance NE, 2013, FRONT NEUROENDOCRIN, V34, P211, DOI 10.1016/j.yfrne.2013.07.003
   Randolph JF, 2004, J CLIN ENDOCR METAB, V89, P1555, DOI 10.1210/jc.2003-031183
   Rao WW, 2020, J AFFECT DISORDERS, V267, P78, DOI 10.1016/j.jad.2020.01.154
   Remes O, 2021, BRAIN SCI, V11, DOI 10.3390/brainsci11121633
   Rodríguez-García C, 2019, MOLECULES, V24, DOI 10.3390/molecules24050917
   Rossmanith WG, 2009, GYNECOL ENDOCRINOL, V25, P303, DOI 10.1080/09513590802632514
   Rubinow DR, 1998, BIOL PSYCHIAT, V44, P839, DOI 10.1016/S0006-3223(98)00162-0
   Ryczkowska K, 2023, ARCH MED SCI, V19, P458, DOI 10.5114/aoms/157308
   Sakai E., 2022, Studies in Natural Products Chemistry, V72, P1, DOI [10.1016/B978-0-12-823944-5.00002-8, DOI 10.1016/B978-0-12-823944-5.00002-8]
   Sanoh S, 2003, J HEALTH SCI, V49, P359, DOI 10.1248/jhs.49.359
   Santoro N, 2004, J CLIN ENDOCR METAB, V89, P2622, DOI 10.1210/jc.2003-031578
   Santoro N, 2015, ENDOCRIN METAB CLIN, V44, P497, DOI 10.1016/j.ecl.2015.05.001
   Santoro N, 2011, OBSTET GYN CLIN N AM, V38, P455, DOI 10.1016/j.ogc.2011.05.004
   Schmidt PJ, 2002, PSYCHONEUROENDOCRINO, V27, P907, DOI 10.1016/S0306-4530(02)00004-5
   Sepehri S, 2024, RSC ADV, V14, P19823, DOI 10.1039/d4ra02867h
   Smethers AD, 2018, MED CLIN N AM, V102, P107, DOI 10.1016/j.mcna.2017.08.009
   Soares CN, 2008, J PSYCHIATR NEUROSCI, V33, P331
   Sowers M, 2007, J CLIN ENDOCR METAB, V92, P895, DOI 10.1210/jc.2006-1393
   Stefanska A, 2015, ADV CLIN CHEM, V72, P1, DOI 10.1016/bs.acc.2015.07.001
   Sternfeld B, 2004, AM J EPIDEMIOL, V160, P912, DOI 10.1093/aje/kwh299
   Stevenson PC, 2006, STUD NAT PROD CHEM, V33, P905
   Taavoni S, 2013, COMPLEMENT THER CLIN, V19, P193, DOI 10.1016/j.ctcp.2013.07.002
   Tchernof A, 2004, J CLIN ENDOCR METAB, V89, P3425, DOI 10.1210/jc.2003-031561
   Nguyen TTH, 2020, BIOPOLYMER-BASED FORMULATIONS, P47, DOI 10.1016/B978-0-12-816897-4.00002-3
   Toth MJ, 2000, ANN NY ACAD SCI, V904, P502
   Öz B, 2023, ARCH PEDIATRIE, V30, P226, DOI 10.1016/j.arcped.2023.02.003
   Uddin LQ, 2017, J CLIN NEUROPHYSIOL, V34, P300, DOI 10.1097/WNP.0000000000000377
   Ugbogu Ositadinma Chinyere, 2021, Heliyon, V7, pe08404, DOI 10.1016/j.heliyon.2021.e08404
   Vandecasteele K, 2012, PHYTOTHER RES, V26, P208, DOI 10.1002/ptr.3528
   Toral MV, 2014, MATURITAS, V77, P93, DOI 10.1016/j.maturitas.2013.10.020
   Vera-Ponce Victor Juan, 2023, Int J Environ Res Public Health, V20, DOI 10.3390/ijerph20031816
   Blasco BV, 2020, PSYCHIAT INVEST, V17, P715, DOI 10.30773/pi.2020.0099
   Voedisch AJ, 2021, CLIN OBSTET GYNECOL, V64, P528, DOI 10.1097/GRF.0000000000000639
   Wadden TA, 2020, AM PSYCHOL, V75, P235, DOI 10.1037/amp0000517
   Walter G, 2004, BIOORG MED CHEM LETT, V14, P4659, DOI 10.1016/j.bmcl.2004.06.098
   Wang RZ, 2024, NAT MENT HEALTH, V2, DOI 10.1038/s44220-023-00158-1
   Wang SG, 2020, BIOMED PHARMACOTHER, V131, DOI 10.1016/j.biopha.2020.110734
   Wang T, 2023, EXPLORATION-PRC, V3, DOI 10.1002/EXP.20220133
   Wang ZS, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000004918
   Wang ZX, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.880230
   Woods NF, 2008, MENOPAUSE, V15, P223, DOI 10.1097/gme.0b013e3181450fc2
   Woods Nancy Fugate, 2005, Am J Med, V118 Suppl 12B, P14
   Woods NF, 2006, MENOPAUSE, V13, P212, DOI 10.1097/01.gme.0000198490.57242.2e
   Xu H, 2020, FRONT PLANT SCI, V11, DOI 10.3389/fpls.2020.571138
   Yaralizadeh M, 2016, MATURITAS, V84, P75, DOI 10.1016/j.maturitas.2015.11.005
   Yokosuka K, 2021, STROKE, V52, P2661, DOI 10.1161/STROKEAHA.120.032042
   Yoshida N, 2018, INT J DENT HYG, V16, P157, DOI 10.1111/idh.12282
   Yuan MJ, 2023, J NUTR, V153, P811, DOI 10.1016/j.tjnut.2023.01.001
   Zhang RX, 2008, J ETHNOPHARMACOL, V117, P199, DOI 10.1016/j.jep.2008.02.018
   Zuiter A. S., 2014, Reference module in chemistry, molecular sciences and chemical engineering, DOI [10.1016/B978-0-12-409547-2.11046-7, DOI 10.1016/B978-0-12-409547-2.11046-7]
NR 144
TC 0
Z9 0
U1 3
U2 3
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PD 2024 OCT 16
PY 2024
DI 10.2174/0109298673317600240930052201
EA OCT 2024
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA J6C1F
UT WOS:001337914500001
PM 39415576
DA 2025-06-11
ER

PT J
AU van den Heuvel, LL
   Smit, AM
   Stalder, T
   Kirschbaum, C
   Seedat, S
   Emsley, R
AF van den Heuvel, Leigh Luella
   Smit, Anna Margaretha
   Stalder, Tobias
   Kirschbaum, Clemens
   Seedat, Soraya
   Emsley, Robin
TI Hair cortisol levels in schizophrenia and metabolic syndrome
SO EARLY INTERVENTION IN PSYCHIATRY
LA English
DT Article
DE cardiovascular disease; first-episode psychosis; hydrocortisone;
   hypothalamic-pituitary-adrenal axis; stress
ID PITUITARY-ADRENAL AXIS; BIPOLAR DISORDER; DRUG-NAIVE; STRESS;
   1ST-EPISODE; MORTALITY; DISEASE; METAANALYSIS; VALIDATION; PSYCHOSIS
AB Aim Individuals with schizophrenia demonstrate higher rates of metabolic syndrome (MetS) than the general population. Hair cortisol concentrations (HCC) reflect longer-term cortisol secretion and can provide additional insights into the role of the hypothalamic pituitary adrenal (HPA) axis in schizophrenia and co-occurring MetS. Methods In a case-control study of 16 patients with schizophrenia (11 first episode psychosis [FEP] and 5 chronic) and 21 controls hair samples, representing a 3-month retrospective window of cortisol, were collected and analysed utilizing liquid chromatography tandem mass spectrometry. We investigated whether schizophrenia and MetS co-occurrence were associated with HCC utilizing multivariate regression models. We also explored the longitudinal trajectory of HCC in FEP patients by conducting a mixed models analysis. Results At baseline HCC were significantly lower (Cohen's d = 0.88) in patients with schizophrenia than in controls (p = .014). HCC increased from baseline to month-12 in FEP patients compared to controls, demonstrating a trend towards significance (p = .097). MetS was not associated with HCC at baseline, but HCC increased significantly from baseline to month-12 in relation to MetS (p = .037). Conclusions In a subgroup of schizophrenia patients, psychosis may be associated with a blunted HPA axis with lower long-term cortisol output. MetS was associated with an increase in HCC and elevated cortisol levels observed in schizophrenia may be related to increased rates of MetS in schizophrenia patients.
C1 [van den Heuvel, Leigh Luella; Smit, Anna Margaretha; Seedat, Soraya; Emsley, Robin] Stellenbosch Univ, Dept Psychiat, Fac Med & Hlth Sci, Clin Bldg,POB 241, ZA-8000 Tygerberg, South Africa.
   [van den Heuvel, Leigh Luella; Seedat, Soraya; Emsley, Robin] Stellenbosch Univ, Fac Med & Hlth Sci, Genom Brain Disorders Res Unit, South African Med Res Council, Cape Town, South Africa.
   [Stalder, Tobias] Univ Siegen, Clin Psychol, Siegen, Germany.
   [Kirschbaum, Clemens] Tech Univ Dresden, Biol Psychol, Dresden, Germany.
C3 Stellenbosch University; Stellenbosch University; South African Medical
   Research Council; Universitat Siegen; Technische Universitat Dresden
RP van den Heuvel, LL (corresponding author), Stellenbosch Univ, Dept Psychiat, Fac Med & Hlth Sci, Clin Bldg,POB 241, ZA-8000 Tygerberg, South Africa.
EM llvdh@sun.ac.za
RI Kirschbaum, Clemens/AAB-1752-2020; van den Heuvel, Leigh/AGV-5481-2022
OI , Clemens/0000-0003-3707-4444; Stalder, Tobias/0000-0001-7558-1274;
   Smit, Anna Margaretha/0000-0003-3966-5213; van den Heuvel,
   Leigh/0000-0003-3884-4754; Seedat, Soraya/0000-0002-5118-786X
FU Deutsche Forschungsgemeinschaft [KI-537/37-1, STA 1213/6-1]; South
   African Department of Science and Technology; South African National
   Research Foundation; South African Research Chairs Initiative in PTSD;
   South African Medical Research Council [MRC-RFA-IFSP-01-2013]
FX Deutsche Forschungsgemeinschaft, Grant/Award Numbers: KI-537/37-1, STA
   1213/6-1; South African Department of Science and Technology and the
   South African National Research Foundation; South African Research
   Chairs Initiative in PTSD; South African Medical Research Council,
   Grant/Award Numbers: SAMRC CLINICIAN RESEARCHER (M.D PHD) SCHOLARSHIP
   PROGRAMME, MRC-RFA-IFSP-01-2013/SHARED ROOTS genetic risk (Laursen et
   al., 2014; Penninx & Lange, 2018; Vancampfort et al., 2015).
CR Aas M, 2019, SCHIZOPHR RES, V213, P65, DOI 10.1016/j.schres.2019.01.011
   Andrade EH, 2016, REV BRAS PSIQUIATR, V38, P11, DOI 10.1590/1516-4446-2014-1634
   Anglin RE, 2006, J NEUROPSYCH CLIN N, V18, P450, DOI 10.1176/appi.neuropsych.18.4.450
   [Anonymous], 2013, J CLIN ENDOCRINOLOGY, V98, P2573, DOI [10.1210/jc.2013-1056, DOI 10.1210/JC.2013-1056]
   [Anonymous], 2018, PRIMARY CARE COMPANI, V20, p18br02279, DOI 10.4088/pcc.18br02279
   Borges S, 2013, PSYCHONEUROENDOCRINO, V38, P603, DOI 10.1016/j.psyneuen.2012.12.025
   Bradley AJ, 2010, J PSYCHOPHARMACOL, V24, P91, DOI 10.1177/1359786810385491
   Chaumette B, 2016, PSYCHONEUROENDOCRINO, V63, P262, DOI 10.1016/j.psyneuen.2015.10.007
   Chiliza B, 2016, EARLY INTERV PSYCHIA, V10, P54, DOI 10.1111/eip.12141
   Correll CU, 2017, WORLD PSYCHIATRY, V16, P163, DOI 10.1002/wps.20420
   De Hert M, 2018, DIALOGUES CLIN NEURO, V20, P31, DOI 10.31887/DCNS.2018.20.1/mdehert
   Farah Julia de Lima, 2015, Case Rep Psychiatry, V2015, P512430, DOI 10.1155/2015/512430
   First M. B., 1997, Structured Clinical Interview for DSM-IV Axis I Disorders, Research Version, Patient Edition
   Gajsak LR, 2017, PSYCHIAT DANUB, V29, P14
   Gao W, 2013, J CHROMATOGR B, V928, P1, DOI 10.1016/j.jchromb.2013.03.008
   Girshkin L, 2014, PSYCHONEUROENDOCRINO, V49, P187, DOI 10.1016/j.psyneuen.2014.07.013
   Hubbard DB, 2019, PSYCHONEUROENDOCRINO, V104, P269, DOI 10.1016/j.psyneuen.2019.03.014
   Kuehl LK, 2015, PSYCHONEUROENDOCRINO, V51, P365, DOI 10.1016/j.psyneuen.2014.09.012
   Laursen TM, 2014, ANNU REV CLIN PSYCHO, V10, P425, DOI 10.1146/annurev-clinpsy-032813-153657
   Manzanares N, 2014, PSYCHONEUROENDOCRINO, V39, P1, DOI 10.1016/j.psyneuen.2013.09.023
   Matsha TE, 2013, INT J CARDIOL, V168, P2954, DOI 10.1016/j.ijcard.2013.03.150
   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Mondelli V, 2015, SCHIZOPHRENIA BULL, V41, P1162, DOI 10.1093/schbul/sbv028
   Penninx BWJH, 2018, DIALOGUES CLIN NEURO, V20, P63
   Piotrowski P, 2017, PSYCHIAT DANUB, V29, P108, DOI 10.24869/psyd.2017.108
   Pulopulos MM, 2014, PSYCHONEUROENDOCRINO, V44, P100, DOI 10.1016/j.psyneuen.2014.03.002
   Seitz R, 2019, PSYCHONEUROENDOCRINO, V105, P155, DOI 10.1016/j.psyneuen.2019.01.010
   Sheehan DV, 1998, J CLIN PSYCHIAT, V59, P22, DOI 10.4088/JCP.09m05305whi
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Stalder T, 2017, PSYCHONEUROENDOCRINO, V77, P261, DOI 10.1016/j.psyneuen.2016.12.017
   Stalder T, 2012, BRAIN BEHAV IMMUN, V26, P1019, DOI 10.1016/j.bbi.2012.02.002
   Streit F, 2016, PSYCHONEUROENDOCRINO, V69, P26, DOI 10.1016/j.psyneuen.2016.03.010
   Touskova TP, 2018, SCHIZOPHR RES, V201, P428, DOI 10.1016/j.schres.2018.06.002
   van den Heuvel LL, 2020, STRESS, V23, P577, DOI 10.1080/10253890.2020.1724949
   van den Heuvel LL, 2020, PSYCHONEUROENDOCRINO, V117, DOI 10.1016/j.psyneuen.2020.104704
   van den Heuvel LL, 2020, PSYCHONEUROENDOCRINO, V113, DOI 10.1016/j.psyneuen.2019.104543
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vancampfort D, 2013, WORLD PSYCHIATRY, V12, P240, DOI 10.1002/wps.20069
   Vuksan-Cusa B, 2014, PSYCHIAT DANUB, V26, P187
   Wennig R, 2000, FORENSIC SCI INT, V107, P5, DOI 10.1016/S0379-0738(99)00146-2
   World Health Organization, 2005, WHO steps surveillance manual: the who stepwise approach to chronic disease risk factor surveillance
   Wosu AC, 2013, ANN EPIDEMIOL, V23, P797, DOI 10.1016/j.annepidem.2013.09.006
   2015, THER DRUG MONIT, V37, P71
NR 43
TC 10
Z9 10
U1 2
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1751-7885
EI 1751-7893
J9 EARLY INTERV PSYCHIA
JI Early Interv. Psychiatry
PD AUG
PY 2022
VL 16
IS 8
BP 902
EP 911
DI 10.1111/eip.13238
EA JAN 2022
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 3L6EZ
UT WOS:000737152400001
PM 34978366
DA 2025-06-11
ER

PT J
AU Vehkala, L
   Ukkola, O
   Kesäniemi, YA
   Kähönen, M
   Nieminen, MS
   Salomaa, V
   Jula, A
   Hörkkö, S
AF Vehkala, Lauri
   Ukkola, Olavi
   Kesaniemi, Y. Antero
   Kahonen, Mika
   Nieminen, Markku S.
   Salomaa, Veikko
   Jula, Antti
   Horkko, Sohvi
TI Plasma IgA antibody levels to malondialdehyde acetaldehyde-adducts are
   associated with inflammatory mediators, obesity and type 2 diabetes
SO ANNALS OF MEDICINE
LA English
DT Article
DE CRP; glucose metabolism; oxidized LDL; TNF-alpha
ID LOW-DENSITY-LIPOPROTEIN; CIRCULATING OXIDIZED LDL;
   NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; PROTEIN ADDUCTS; IMMUNE-SYSTEM; ATHEROSCLEROSIS; AUTOANTIBODIES
AB Aim. Obesity and type 2 diabetes (T2D) associate with increased oxidative stress. Malondialdehyde acetaldehyde (MAA) adducts have been suggested to be one of the antigenic epitopes in MDA-LDL responsible for the antibody recognition. Our aim was to investigate the associations between plasma IgA antibodies to MAA-LDL, inflammatory markers, adipokines, obesity, and T2D.
   Methods. IgA to MAA-LDL were measured in a subsample (n = 1507) of the Finnish Health 2000 survey. The associations between antibody levels, obesity, TNF-alpha, IL-6, high-sensitivity (hs) CRP, resistin, adiponectin, fasting plasma (fp) glucose, fp-insulin, glycosylated hemoglobin (Hb-A1C), and T2D were investigated.
   Results. IgA to MAA-LDL associated positively with fasting plasma insulin. IgA to MAA-LDL were higher among subjects with T2D (P < 0.001) compared to subjects with normal glucose metabolism. IgA to MAA-LDL associated with obesity, but was not independently (P = 0.002, not significant after correction for multiple tests) associated with T2D in logistic regression analysis. IgA to MAA-LDL, obesity, and TNF-alpha all associated with markers of glucose metabolism.
   Conclusions. T2D subjects had increased IgA to MAA-LDL compared to subjects with normal glucose metabolism. The data suggest that the associations between IgA to MAA-LDL and markers of glucose metabolism were independent of TNF-alpha but dependent on components of the metabolic syndrome.
C1 [Vehkala, Lauri; Horkko, Sohvi] Univ Oulu, Inst Diagnost, Dept Med Microbiol & Immunol, FI-90014 Oulu, Finland.
   [Vehkala, Lauri; Horkko, Sohvi] Med Res Ctr, Oulu, Finland.
   [Ukkola, Olavi; Kesaniemi, Y. Antero] Univ Oulu, Bioctr Oulu, FI-90014 Oulu, Finland.
   [Vehkala, Lauri; Ukkola, Olavi; Kesaniemi, Y. Antero; Horkko, Sohvi] Oulu Univ Hosp, Nordlab Oulu, Oulu, Finland.
   [Kahonen, Mika] Tampere Univ Hosp, Dept Clin Physiol, Tampere, Finland.
   [Kahonen, Mika] Univ Tampere, FIN-33101 Tampere, Finland.
   [Nieminen, Markku S.] Univ Helsinki, Dept Med, Helsinki, Finland.
   [Salomaa, Veikko] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.
   [Jula, Antti] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.
C3 University of Oulu; University of Oulu; University of Oulu; Tampere
   University; Tampere University Hospital; Tampere University; University
   of Helsinki; Finland National Institute for Health & Welfare; Finland
   National Institute for Health & Welfare
RP Hörkkö, S (corresponding author), Univ Oulu, Inst Diagnost, Dept Med Microbiol & Immunol, Oulu POB 5000, FI-90014 Oulu, Finland.
EM sohvi.horkko@oulu.fi
RI Gratten, Jacob/G-1485-2011; Salomaa, Veikko/AEO-8209-2022
OI Kahonen, Mika/0000-0002-4510-7341
FU Academy of Finland; Sigrid Juselius Foundation; Finnish Foundation for
   Cardiovascular Research; Sohlberg Foundation; Medical Research Fund of
   Tampere University Hospital; Finnish Cultural Foundation
FX The authors report no conflicts of interest. This work was supported by
   funding from the Academy of Finland, the Sigrid Juselius Foundation, the
   Finnish Foundation for Cardiovascular Research, the Sohlberg Foundation,
   the Medical Research Fund of Tampere University Hospital, and the
   Finnish Cultural Foundation.
CR Aromaa A., 2004, Health and Functional Capacity in Finland. Baseline Results of the Health 2000 Health Examination Survey
   Chou MY, 2009, J CLIN INVEST, V119, P1335, DOI 10.1172/JCI36800
   Duryee MJ, 2010, FREE RADICAL BIO MED, V49, P1480, DOI 10.1016/j.freeradbiomed.2010.08.001
   ESTERBAUER H, 1991, FREE RADICAL BIO MED, V11, P81, DOI 10.1016/0891-5849(91)90192-6
   Fagerberg B, 2001, NUTR METAB CARDIOVAS, V11, P227
   Frostegard J, 1997, ARTERIOSCL THROM VAS, V17, P963, DOI 10.1161/01.ATV.17.5.963
   Gonzalez-Quintela A, 2008, CLIN EXP IMMUNOL, V151, P42, DOI 10.1111/j.1365-2249.2007.03545.x
   Hansson GK, 2011, NAT IMMUNOL, V12, P204, DOI 10.1038/ni.2001
   Hill GE, 1998, ATHEROSCLEROSIS, V141, P107, DOI 10.1016/S0021-9150(98)00153-1
   Holvoet P, 2001, ARTERIOSCL THROM VAS, V21, P844, DOI 10.1161/01.ATV.21.5.844
   Holvoet P, 2008, JAMA-J AM MED ASSOC, V299, P2287, DOI 10.1001/jama.299.19.2287
   Hörkkö S, 2000, FREE RADICAL BIO MED, V28, P1771, DOI 10.1016/S0891-5849(00)00333-6
   HOTAMISLIGIL GS, 1995, J CLIN INVEST, V95, P2409, DOI 10.1172/JCI117936
   Hu E, 1996, J BIOL CHEM, V271, P10697, DOI 10.1074/jbc.271.18.10697
   Hulthe J, 2002, ARTERIOSCL THROM VAS, V22, P1162, DOI 10.1161/01.ATV.0000021150.63480.CD
   Hulthe J, 2001, CLIN SCI, V100, P371, DOI [10.1042/CS20000269, 10.1042/cs1000371]
   Karvonen J, 2003, CIRCULATION, V108, P2107, DOI 10.1161/01.CIR.0000092891.55157.A7
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Kelly AS, 2010, PEDIATR DIABETES, V11, P552, DOI 10.1111/j.1399-5448.2009.00640.x
   Kharbanda KK, 2001, ALCOHOL, V25, P123, DOI 10.1016/S0741-8329(01)00174-4
   Kleemann R, 2008, CARDIOVASC RES, V79, P360, DOI 10.1093/cvr/cvn120
   Kunnari AM, 2009, REGUL PEPTIDES, V157, P57, DOI 10.1016/j.regpep.2009.05.002
   Lappalainen J, 2011, ATHEROSCLEROSIS, V214, P357, DOI 10.1016/j.atherosclerosis.2010.11.024
   MANSON JAE, 1990, NEW ENGL J MED, V322, P882, DOI 10.1056/NEJM199003293221303
   Mertens A, 2003, CIRCULATION, V107, P1640, DOI 10.1161/01.CIR.0000056523.08033.9F
   Mutlu-Türkoglu Ü, 2003, CLIN EXP MED, V2, P171, DOI 10.1007/s102380300002
   Otten MA, 2004, IMMUNOL LETT, V92, P23, DOI 10.1016/j.imlet.2003.11.018
   Pickup JC, 1997, DIABETOLOGIA, V40, P1286, DOI 10.1007/s001250050822
   Plomgaard P, 2005, DIABETES, V54, P2939, DOI 10.2337/diabetes.54.10.2939
   Qin BL, 2007, DIABETES, V56, P450, DOI 10.2337/db06-0518
   Resch U, 2006, BRIT J CLIN PHARMACO, V61, P262, DOI 10.1111/j.1365-2125.2005.02568.x
   Saad AF, 2006, J LIPID RES, V47, P1975, DOI 10.1194/jlr.M600064-JLR200
   Sämpi M, 2008, J AM COLL CARDIOL, V52, P1370, DOI 10.1016/j.jacc.2008.06.047
   Sämpi M, 2010, J CLIN ENDOCR METAB, V95, P2467, DOI 10.1210/jc.2009-1858
   Santaniemi M, 2006, EUR J ENDOCRINOL, V155, P745, DOI 10.1530/eje.1.02287
   Schrauwen P, 2004, DIABETES, V53, P1412, DOI 10.2337/diabetes.53.6.1412
   Shoelson SE, 2007, GASTROENTEROLOGY, V132, P2169, DOI 10.1053/j.gastro.2007.03.059
   Shoma S, 2011, EUR J CLIN MICROBIOL, V30, P521, DOI 10.1007/s10096-010-1113-x
   Sipilä K, 2007, METABOLISM, V56, P320, DOI 10.1016/j.metabol.2006.10.008
   Sjöberg BG, 2009, ATHEROSCLEROSIS, V203, P528, DOI 10.1016/j.atherosclerosis.2008.07.009
   Steppan CM, 2001, NATURE, V409, P307, DOI 10.1038/35053000
   Su J, 2006, ATHEROSCLEROSIS, V188, P160, DOI 10.1016/j.atherosclerosis.2005.10.017
   Subbanagounder G, 2002, J BIOL CHEM, V277, P7271, DOI 10.1074/jbc.M107602200
   Suzuki Koji, 2003, Asian Pac J Cancer Prev, V4, P259
   Thiele GM, 1998, ALCOHOL CLIN EXP RES, V22, P1731, DOI 10.1097/00000374-199811000-00016
   Tsimikas S, 2012, J AM COLL CARDIOL, V60, P2218, DOI 10.1016/j.jacc.2012.08.979
   Tuma DJ, 2001, CHEM RES TOXICOL, V14, P822, DOI 10.1021/tx000222a
   Tuma DJ, 1996, HEPATOLOGY, V23, P872, DOI 10.1053/jhep.1996.v23.pm0008666344
   van Egmond M, 2000, NAT MED, V6, P680, DOI 10.1038/76261
   Vasankari T, 2001, INT J OBESITY, V25, P205, DOI 10.1038/sj.ijo.0801533
   Virella G, 2002, CLIN IMMUNOL, V105, P81, DOI 10.1006/clim.2002.5269
   Wang ZY, 2011, INFLAMM RES, V60, P525, DOI 10.1007/s00011-010-0298-x
   Weinbrenner T, 2006, AM J CLIN NUTR, V83, P30
   Willis MS, 2003, INT IMMUNOPHARMACOL, V3, P1381, DOI 10.1016/S1567-5769(03)00136-X
   Wonisch W, 2012, AGING MALE, V15, P159, DOI 10.3109/13685538.2012.669436
NR 55
TC 31
Z9 31
U1 0
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PD DEC
PY 2013
VL 45
IS 8
BP 501
EP 510
DI 10.3109/07853890.2013.841322
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 255RO
UT WOS:000327257700002
PM 24131174
OA Bronze
DA 2025-06-11
ER

PT J
AU Mallorquí-Bagué, N
   Lozano-Madrid, M
   Vintró-Alcaraz, C
   Forcano, L
   Díaz-López, A
   Galera, A
   Fernández-Carrión, R
   Granero, R
   Jiménez-Murcia, S
   Corella, D
   Pintó, X
   Cuenca-Royo, A
   Bulló, M
   Salas-Salvadó, J
   de la Torre, R
   Fernández-Aranda, F
AF Mallorqui-Bague, Nuria
   Lozano-Madrid, Maria
   Vintro-Alcaraz, Cristina
   Forcano, Laura
   Diaz-Lopez, Andres
   Galera, Ana
   Fernandez-Carrion, Rebeca
   Granero, Roser
   Jimenez-Murcia, Susana
   Corella, Dolores
   Pinto, Xavier
   Cuenca-Royo, Aida
   Bullo, Monica
   Salas-Salvado, Jordi
   de la Torre, Rafael
   Fernandez-Aranda, Fernando
TI Effects of a psychosocial intervention at one-year follow-up in a
   PREDIMED-plus sample with obesity and metabolic syndrome
SO SCIENTIFIC REPORTS
LA English
DT Article
ID IMPULSIVE BEHAVIOR SCALE; FOOD ADDICTION; PHYSICAL-ACTIVITY; GAMBLING
   DISORDER; EATING-DISORDERS; SPANISH VERSION; DEPRESSION; RISK; DIET;
   ASSOCIATION
AB This study examines if overweight/obesity are related to higher impulsivity, food addiction and depressive symptoms, and if these variables could be modified after 1 year of a multimodal intervention (diet, physical activity, psychosocial support). 342 adults (55-75 years) with overweight/obesity and metabolic syndrome (MetS) from the PREDIMED-Plus Cognition study were randomized to the intervention or to the control group (lifestyle recommendations). Cognitive and psychopathological assessments were performed at baseline and after 1-year follow-up. At baseline, higher impulsivity was linked to higher food addiction and depressive symptoms, but not to body mass index (BMI). Food addiction not only predicted higher BMI and depressive symptoms, but also achieved a mediational role between impulsivity and BMI/depressive symptoms. After 1 year, patients in both groups reported significant decreases in BMI, food addiction and impulsivity. BMI reduction and impulsivity improvements were higher in the intervention group. Higher BMI decrease was achieved in individuals with lower impulsivity. Higher scores in food addiction were also related to greater post-treatment impulsivity. To conclude, overweight/obesity are related to higher impulsivity, food addiction and depressive symptoms in mid/old age individuals with MetS. Our results also highlight the modifiable nature of the studied variables and the interest of promoting multimodal interventions within this population.
C1 [Mallorqui-Bague, Nuria] Hosp Santa Creu & Sant Pau, Addict Behav Unit, Dept Psychiat, Biomed Res Inst St Pau IIB St Pau, Barcelona, Spain.
   [Mallorqui-Bague, Nuria; Lozano-Madrid, Maria; Vintro-Alcaraz, Cristina; Jimenez-Murcia, Susana; Fernandez-Aranda, Fernando] Univ Hosp Bellvitge IDIBELL, Dept Psychiat, Feixa Llarga S-N, Barcelona 08907, Spain.
   [Mallorqui-Bague, Nuria; Lozano-Madrid, Maria; Vintro-Alcaraz, Cristina; Forcano, Laura; Diaz-Lopez, Andres; Galera, Ana; Fernandez-Carrion, Rebeca; Granero, Roser; Jimenez-Murcia, Susana; Corella, Dolores; Pinto, Xavier; Cuenca-Royo, Aida; Bullo, Monica; Salas-Salvado, Jordi; de la Torre, Rafael; Fernandez-Aranda, Fernando] Inst Salud Carlos III ISCIII, Consorcio CIBER, MP Fisiopatol Obesidad & Nutr CIBERObn, Madrid, Spain.
   [Forcano, Laura; Cuenca-Royo, Aida; de la Torre, Rafael] Inst Hosp del Mar Invest Med IMIM, Integrat Pharmacol & Neurosci Syst, Dr Aiguder 88, Barcelona 08003, Spain.
   [Diaz-Lopez, Andres; Bullo, Monica; Salas-Salvado, Jordi] Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Unitat Nutr Humana, Reus, Spain.
   [Galera, Ana; Pinto, Xavier] Univ Hosp Bellvitge, Lipids & Vasc Risk Unit, Internal Med, Barcelona, Spain.
   [Fernandez-Carrion, Rebeca; Corella, Dolores] Univ Valencia, Dept Prevent Med, Valencia, Spain.
   [Granero, Roser] Univ Autonoma Barcelona, Dept Psicobiol & Metodol, Barcelona, Spain.
   [Jimenez-Murcia, Susana; Fernandez-Aranda, Fernando] Univ Barcelona, Sch Med & Hlth Sci, Dept Clin Sci, Barcelona, Spain.
   [Diaz-Lopez, Andres; Bullo, Monica; Salas-Salvado, Jordi] Inst Invest Sanitaria Pere Virgili IISPV, Reus, Spain.
   [Salas-Salvado, Jordi] Univ Hosp St Joan Reus, Nutr Unit, Reus, Spain.
   [de la Torre, Rafael] Univ Pompeu Fabra CEXS UPF, Dept Ciencies Expt & Salut, Barcelona, Spain.
   [Diaz-Lopez, Andres] Univ Rovira & Virgili URV, Reus, Spain.
C3 Hospital of Santa Creu i Sant Pau; Institut d'Investigacio Biomedica de
   Bellvitge (IDIBELL); Bellvitge University Hospital; University of
   Barcelona; Hospital del Mar Research Institute; Hospital del Mar;
   Universitat Rovira i Virgili; Institut d'Investigacio Biomedica de
   Bellvitge (IDIBELL); Bellvitge University Hospital; University of
   Barcelona; University of Valencia; Autonomous University of Barcelona;
   University of Barcelona; Universitat Rovira i Virgili; Institut
   d'Investigacio Sanitaria Pere Virgili (IISPV); Pompeu Fabra University;
   Universitat Rovira i Virgili
RP Fernández-Aranda, F (corresponding author), Univ Hosp Bellvitge IDIBELL, Dept Psychiat, Feixa Llarga S-N, Barcelona 08907, Spain.; de la Torre, R; Fernández-Aranda, F (corresponding author), Inst Salud Carlos III ISCIII, Consorcio CIBER, MP Fisiopatol Obesidad & Nutr CIBERObn, Madrid, Spain.; de la Torre, R (corresponding author), Inst Hosp del Mar Invest Med IMIM, Integrat Pharmacol & Neurosci Syst, Dr Aiguder 88, Barcelona 08003, Spain.; Fernández-Aranda, F (corresponding author), Univ Barcelona, Sch Med & Hlth Sci, Dept Clin Sci, Barcelona, Spain.; de la Torre, R (corresponding author), Univ Pompeu Fabra CEXS UPF, Dept Ciencies Expt & Salut, Barcelona, Spain.
EM RTorre@imim.es; ffernandez@bellvitgehospital.cat
RI Corella, Dolores/L-9888-2014; FORCANO, LAURA/AAP-1933-2020;
   Mallorquí-Bagué, Núria/Q-1721-2015; Torre, Riccardo/N-9558-2014;
   Fernandez-Carrion, Rebeca/AAA-5713-2019; Pintó, Xavier/AGI-4297-2022;
   JIMENEZ-MURCIA, SUSANA/L-9786-2014; Salas-Salvado, Jordi/C-7229-2017;
   Lozano Madrid, Maria/IQV-7373-2023; Forcano Gamazo, Laura/B-1154-2017;
   Vintro Alcaraz, Cristina/R-7030-2018; Bullo, Monica/F-2925-2016;
   Granero, Roser/F-9492-2016; FERNANDEZ-ARANDA, FERNANDO/L-9762-2014
OI JIMENEZ-MURCIA, SUSANA/0000-0002-3596-8033; Salas-Salvado,
   Jordi/0000-0003-2700-7459; Lozano Madrid, Maria/0000-0003-3833-317X;
   Forcano Gamazo, Laura/0000-0002-8478-1451; Cuenca Royo,
   Aida/0000-0001-8551-5457; Vintro Alcaraz, Cristina/0000-0001-9453-8810;
   Diaz-Lopez, Andres/0000-0002-7500-5629; Bullo,
   Monica/0000-0002-0218-7046; Granero, Roser/0000-0001-6308-3198;
   FERNANDEZ-ARANDA, FERNANDO/0000-0002-2968-9898
FU Department of Health of the Generalitat de Catalunya [SLT006/17/00246,
   SLT002/16/00045]; Instituto de Salud Carlos III (ISCIII); Spanish
   Government Official Agency through the Fondo de Investigacion para la
   Salud (FIS); European Regional Development Fund [PI13/00233, PI13/00728,
   PI13/01123, PI13/00462, PI16/00533, PI16/00366, PI16/01094, PI16/00501,
   PI19/00017, PI19/00781, PI19/01032, PI19/00576]; Especial Action
   Project; European Research Council [340918]; Recercaixa [2013ACUP00194];
   EU-H2020 Grants [Eat2beNICE/H2020-SFS-2016-2, 728018,
   PRIME/H2020-SC1-BHC-2018-2020, 847879]; Instituto Salud Carlos III
   (Fondo Investigacion Sanitario, FIS) [PI17/01167]; Generalitat
   Valenciana [PROMETEO/2017/017]; Grant FEA/SEA; ICREA under the ICREA
   Academia programme; Ministerio de Educacion, Cultura y Deporte
   [FPU15/02911, FPU16/01453]; DIUE de la Generalitat de Catalunya from the
   Departament d'Economia i Coneixement de la Generalitat de Catalunya
   (Spain) [2017 SGR 138]
FX Study resulting from the following grants: SLT006/17/00246 and
   SLT002/16/00045, funded by the Department of Health of the Generalitat
   de Catalunya by the calls "Accio instrumental de programes de recerca
   orientats en l'ambit de la recerca i la innovacio en salut" and "Pla
   estrategic de recerca i innovacio en salut (PERIS)". We thank CERCA
   Programme/Generalitat de Catalunya for institutional support. This
   project was funded by Instituto de Salud Carlos III (ISCIII), the
   Spanish Government Official Agency for funding biomedical research-with
   competitive grants leaded by Jordi Salas-Salvado and Josep Vidal for the
   periods 2014-2016, 2015-2017, 2017-2019 and 2018-2020, through the Fondo
   de Investigacion para la Salud (FIS), which is co-funded by the European
   Regional Development Fund [grants: PI13/00233, PI13/00728, PI13/01123,
   PI13/00462, PI16/00533, PI16/00366, PI16/01094, PI16/00501, PI19/00017,
   PI19/00781, PI19/01032, PI19/00576]; the Especial Action Project
   entitled: Implementacion y evaluacion de una intervencion intensiva
   sobre la actividad fisica Cohorte PREDIMED-Plus grant to Jordi
   Salas-Salvado; the European Research Council [Advanced Research Grant
   2014-2019; agreement #340918] granted to Miguel Angel Martinez-Gonzalez;
   the Recercaixa (number 2013ACUP00194) grant to Jordi Salas-Salvado. This
   research was also partially funded by EU-H2020 Grants
   (Eat2beNICE/H2020-SFS-2016-2; Ref 728018; and
   PRIME/H2020-SC1-BHC-2018-2020; Ref: 847879) and Instituto Salud Carlos
   III (Fondo Investigacion Sanitario, FIS: PI17/01167), Grant
   PROMETEO/2017/017 (Generalitat Valenciana) and Grant FEA/SEA 2017 for
   Primary Care Research. This work is also partially supported by ICREA
   under the ICREA Academia programme. None of these funding sources plays
   any role in the design, collection, analysis, or interpretation of the
   data or in the decision to submit manuscripts for publication. MLM and
   CVA are supported by a predoctoral Grant of the Ministerio de Educacion,
   Cultura y Deporte (FPU15/02911 and FPU16/01453). This work was supported
   by grants from DIUE de la Generalitat de Catalunya 2017 SGR 138 (RTF)
   from the Departament d'Economia i Coneixement de la Generalitat de
   Catalunya (Spain). The funders of the study had no role in study design,
   data collection, data analysis, data interpretation, or writing of the
   report.
CR Alemán JA, 2016, NUTRIENTS, V8, DOI 10.3390/nu8110680
   Aiello M, 2018, BRAIN COGNITION, V123, P103, DOI 10.1016/j.bandc.2018.03.006
   ALBERS U, 2011, OBES REV, V12, P583, DOI DOI 10.1111/J.1467-789X.2011.00878.X
   Amlung M, 2016, PSYCHOL MED, V46, P2423, DOI 10.1017/S0033291716000866
   Association AP, 2013, Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition
   Atlantis E, 2008, INT J OBESITY, V32, P881, DOI 10.1038/ijo.2008.54
   Avila C, 2015, CURR OBES REP, V4, P303, DOI 10.1007/s13679-015-0164-9
   Bari A, 2013, PROG NEUROBIOL, V108, P44, DOI 10.1016/j.pneurobio.2013.06.005
   Barnard ND, 2009, AM J CLIN NUTR, V89, pS1588, DOI 10.3945/ajcn.2009.26736H
   Barrett P, 2007, PERS INDIV DIFFER, V42, P815, DOI 10.1016/j.paid.2006.09.018
   Bechara A, 2000, BRAIN, V123, P2189, DOI 10.1093/brain/123.11.2189
   Bechara A, 1997, SCIENCE, V275, P1293, DOI 10.1126/science.275.5304.1293
   Beck A. T., 1996, BDI 2 BECK DEPRESSIO
   Becker W., 2004, Scandinavian Journal of Nutrition, V48, P178, DOI 10.1080/1102680410003794
   Blaine B, 2008, J HEALTH PSYCHOL, V13, P1190, DOI 10.1177/1359105308095977
   Brogan A, 2011, J PSYCHOSOM RES, V70, P189, DOI 10.1016/j.jpsychores.2010.07.012
   Burnay J, 2015, COMPUT HUM BEHAV, V43, P28, DOI 10.1016/j.chb.2014.10.039
   Carmen M, 2020, J EAT DISORD, V8, DOI 10.1186/s40337-020-0278-7
   Conners C.K., 2004, Conners Continuous Performance Test, V2nd
   Coskunpinar A, 2013, ALCOHOL CLIN EXP RES, V37, P1441, DOI 10.1111/acer.12131
   Cyders MA, 2008, PSYCHOL BULL, V134, P807, DOI 10.1037/a0013341
   Daneshzad E, 2020, J SCI FOOD AGR, V100, P2946, DOI 10.1002/jsfa.10322
   Davis C, 2011, APPETITE, V57, P711, DOI 10.1016/j.appet.2011.08.017
   de Wit L, 2010, PSYCHIAT RES, V178, P230, DOI 10.1016/j.psychres.2009.04.015
   Del-Ponte B, 2019, J AFFECT DISORDERS, V252, P160, DOI 10.1016/j.jad.2019.04.061
   Delgado-Rico E, 2012, BEHAV PHARMACOL, V23, P609, DOI 10.1097/FBP.0b013e328356c3ac
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Eisinger Andrea, 2016, Neuropsychopharmacol Hung, V18, P45
   Evenden JL, 1999, PSYCHOPHARMACOLOGY, V146, P348, DOI 10.1007/PL00005481
   FINNER H, 1993, J AM STAT ASSOC, V88, P920, DOI 10.2307/2290782
   FRIEDMAN MA, 1995, PSYCHOL BULL, V117, P3, DOI 10.1037/0033-2909.117.1.3
   Gariepy G, 2010, INT J OBESITY, V34, P407, DOI 10.1038/ijo.2009.252
   Gearhardt AN, 2016, PSYCHOL ADDICT BEHAV, V30, P113, DOI 10.1037/adb0000136
   Gearhardt AN, 2009, APPETITE, V52, P430, DOI 10.1016/j.appet.2008.12.003
   Golden C.J., 1978, age, V15, P90
   Golden C.J., 1978, STROOP COLOR WORD TE, P1978
   Granero R, 2018, FRONT PSYCHIATRY, V9, DOI 10.3389/fpsyt.2018.00208
   Gunstad J, 2006, Eat Weight Disord, V11, pe15
   Guzzardi MA, 2018, EUR EAT DISORD REV, V26, P657, DOI 10.1002/erv.2652
   Hershberger A, 2018, INT J MENT HEALTH AD, V16, P366, DOI 10.1007/s11469-017-9783-6
   Holsen LM, 2005, NEUROIMAGE, V27, P669, DOI 10.1016/j.neuroimage.2005.04.043
   Hu G, 2004, ARCH INTERN MED, V164, P892, DOI 10.1001/archinte.164.8.892
   Jeon CY, 2007, DIABETES CARE, V30, P744, DOI 10.2337/dc06-1842
   Kaminsky J, 2002, OBES SURG, V12, P14, DOI 10.1381/096089202321144513
   KIEHM TG, 1976, AM J CLIN NUTR, V29, P895, DOI 10.1093/ajcn/29.8.895
   Kline RB, 2011, Principles and practice of structural equation modelling
   Kubik JF, 2013, J OBES, V2013, DOI 10.1155/2013/837989
   Kulendran M, 2014, INT J OBESITY, V38, P507, DOI 10.1038/ijo.2013.198
   Lakka TA, 2007, APPL PHYSIOL NUTR ME, V32, P76, DOI 10.1139/h06-113
   Li TY, 2006, CIRCULATION, V113, P499, DOI 10.1161/CIRCULATIONAHA.105.574087
   Lin KP, 2014, BIOL RES NURS, V16, P327, DOI 10.1177/1099800413500138
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Lykouras L, 2008, DIGEST DIS, V26, P36, DOI 10.1159/000109384
   MacKillop J, 2016, PSYCHOPHARMACOLOGY, V233, P3361, DOI 10.1007/s00213-016-4372-0
   Mallorquí-Bagué N, 2019, EUR PSYCHIAT, V61, P9, DOI 10.1016/j.eurpsy.2019.06.006
   Mallorquí-Bagué N, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0163901
   Marazziti D, 2014, CNS SPECTRUMS, V19, P293, DOI 10.1017/S1092852913000667
   Martínez-González MA, 2019, INT J EPIDEMIOL, V48, P387, DOI 10.1093/ije/dyy225
   Meda SA, 2009, BEHAV PHARMACOL, V20, P390, DOI 10.1097/FBP.0b013e32833113a3
   Mobbs O, 2010, PATIENT EDUC COUNS, V79, P372, DOI 10.1016/j.pec.2010.03.003
   Mole TB, 2015, PSYCHOL MED, V45, P771, DOI 10.1017/S0033291714001834
   Molendijk M, 2018, J AFFECT DISORDERS, V226, P346, DOI 10.1016/j.jad.2017.09.022
   Murphy CM, 2014, APPETITE, V73, P45, DOI 10.1016/j.appet.2013.10.008
   Oh H, 2021, J DUAL DIAGN, V17, P34, DOI 10.1080/15504263.2020.1839827
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Pignatti R, 2006, Eat Weight Disord, V11, P126
   Pivarunas B, 2015, EAT BEHAV, V19, P9, DOI 10.1016/j.eatbeh.2015.06.007
   Pursey K., 2014, OBES RES CLIN PRACT, V8, P80, DOI [10.1016/j.orcp.2014.10.146, DOI 10.1016/J.ORCP.2014.10.146]
   Quintero MJ, 2020, ADDICT BEHAV, V111, DOI 10.1016/j.addbeh.2020.106533
   Romain AJ, 2018, J AFFECT DISORDERS, V225, P381, DOI 10.1016/j.jad.2017.08.065
   Rose MH, 2018, J PEDIATR PSYCHOL, V43, P443, DOI 10.1093/jpepsy/jsx127
   Rose P, 2014, J BEHAV ADDICT, V3, P128, DOI 10.1556/JBA.3.2014.011
   Salas-Salvadó J, 2019, DIABETES CARE, V42, P777, DOI 10.2337/dc18-0836
   Saunders TJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0079143
   Sayón-Orea C, 2019, JAMA-J AM MED ASSOC, V322, P1486, DOI 10.1001/jama.2019.14630
   Smith E, 2011, OBES REV, V12, P740, DOI 10.1111/j.1467-789X.2011.00920.x
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Steward T, 2018, EUR EAT DISORD REV, V26, P574, DOI 10.1002/erv.2636
   Steward T, 2017, EUR EAT DISORD REV, V25, P601, DOI 10.1002/erv.2543
   Stice E, 2016, J NEUROSCI, V36, P6949, DOI 10.1523/JNEUROSCI.4365-15.2016
   Stice E, 2011, J NEUROSCI, V31, P4360, DOI 10.1523/JNEUROSCI.6604-10.2011
   Stinson EJ, 2018, PHYSIOL BEHAV, V186, P25, DOI 10.1016/j.physbeh.2018.01.005
   van Meer F, 2016, CURR DIABETES REP, V16, DOI 10.1007/s11892-016-0773-z
   VanderBroek-Stice L, 2017, APPETITE, V112, P59, DOI 10.1016/j.appet.2017.01.009
   Verdejo-García A, 2010, J PERS ASSESS, V92, P70, DOI 10.1080/00223890903382369
   Waldstein SR, 2006, INT J OBESITY, V30, P201, DOI 10.1038/sj.ijo.0803114
   Walther K, 2010, HUM BRAIN MAPP, V31, P1052, DOI 10.1002/hbm.20916
   Webster CC, 2019, DIABET METAB SYND OB, V12, P2567, DOI 10.2147/DMSO.S227090
   Whiteside SP, 2005, EUR J PERSONALITY, V19, P559, DOI 10.1002/per.556
   Wolz I, 2017, COMPR PSYCHIAT, V74, P118, DOI 10.1016/j.comppsych.2017.01.012
   Wolz I, 2016, FRONT PSYCHOL, V7, DOI 10.3389/fpsyg.2016.00061
   Zang Y, 2019, MEDICINE, V98, DOI 10.1097/MD.0000000000017980
   Zorrilla EP, 2019, FRONT BEHAV NEUROSCI, V13, DOI 10.3389/fnbeh.2019.00136
NR 93
TC 12
Z9 12
U1 1
U2 12
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 28
PY 2021
VL 11
IS 1
AR 9144
DI 10.1038/s41598-021-88298-1
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA SK2NW
UT WOS:000656057700003
PM 33911087
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rönngren, YM
   Björk, A
   Haage, D
   Kristiansen, L
AF Ronngren, Y. M.
   Bjork, A.
   Haage, D.
   Kristiansen, L.
TI LIFEHOPE.EU: lifestyle and healthy outcome in physical education
SO JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING
LA English
DT Article
DE cognitive adaptive training; cognitive disabilities; lifestyle
   intervention programme; nursing care; physical activity; severe mental
   illness
ID QUALITY-OF-LIFE; MENTAL-ILLNESS; METABOLIC SYNDROME; PEOPLE; STATE;
   SCHIZOPHRENIA; INTERVENTIONS; INDIVIDUALS; PREVALENCE; DEFICITS
AB People with severe mental illness (SMIs) are more prone to physical illnesses, increased mortality and cognitive impairments, all of which negatively influence their daily lives. Physical activity (PHYS) programmes have helped alleviate SMI. LIFEHOPE is an ongoing research project with the purpose of developing a sustainable lifestyle intervention for physical and mental health. PHYS/cognitive adaptation training (CAT) is a newly created lifestyle intervention that provides group education and is based on CAT. It provides individualized support for PHYS and dietary change in a natural nursing environment. The aim of this study was to obtain further knowledge for developing a sustainable lifestyle programme by exploring psychiatric clients' experiences with PHYS and lifestyle habits, which we did by interviewing a local reference group, community mental healthcare users and community mental healthcare workers. Then, we developed a lifestyle programme for people with SMI using information obtained from these focus group interviews. Our results suggest that there is a need for support and education, as well as active interventions, in carrying out PHYS and dietary changes among people with SMIs, and the PHYS/CAT may be a useful strategy.
C1 [Ronngren, Y. M.; Bjork, A.; Haage, D.; Kristiansen, L.] Mid Sweden Univ, Dept Nursing, SE-85170 Sundsvall, Sweden.
C3 Mid-Sweden University
RP Rönngren, YM (corresponding author), Mid Sweden Univ, Dept Nursing Sci, Dept Nursing, Holmgatan 10, SE-85170 Sundsvall, Sweden.
EM ylva.ronngren@miun.se
OI Kristiansen, Lisbeth/0000-0001-7959-606X
CR Acil AA, 2008, J PSYCHIATR MENT HLT, V15, P808, DOI 10.1111/j.1365-2850.2008.01317.x
   [Anonymous], 2013, GLOB STRAT DIET PHYS
   [Anonymous], 1999, Personnel Reform Evaluation Database: Baseline Report FAA
   [Anonymous], 2009, FOLKH 2009
   Brunero S, 2010, INT J NURS STUD, V47, P753, DOI 10.1016/j.ijnurstu.2009.11.004
   Carrà G, 2014, SOC PSYCH PSYCH EPID, V49, P1739, DOI 10.1007/s00127-014-0835-y
   Currid T., 2012, BRIT J COMMUNITY NUR, V17, P21
   De Hert M, 2009, WORLD PSYCHIATRY, V8, P15
   Fitzgerald PB, 2008, HUM BRAIN MAPP, V29, P683, DOI 10.1002/hbm.20426
   Fleischhacker WW, 2009, J CLIN PSYCHIAT, V70, P1191
   Forsberg KA, 2010, J CLIN NURS, V19, P1519, DOI 10.1111/j.1365-2702.2009.03010.x
   Gorczynski P, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004412.pub2
   Graneheim UH, 2004, NURS EDUC TODAY, V24, P105, DOI 10.1016/j.nedt.2003.10.001
   Green MF, 2000, SCHIZOPHRENIA BULL, V26, P119, DOI 10.1093/oxfordjournals.schbul.a033430
   GUBA EG, 1981, ECTJ-EDUC COMMUN TEC, V29, P75
   Hägg S, 2006, INT CLIN PSYCHOPHARM, V21, P93
   Hansen JP, 2012, SCHIZOPHR RES, V135, P105, DOI 10.1016/j.schres.2011.12.014
   Happell B, 2013, INT J MENT HEALTH NU, V22, P399, DOI 10.1111/inm.12006
   Happell B, 2013, NURS EDUC TODAY, V33, P396, DOI 10.1016/j.nedt.2013.01.015
   Happell B, 2012, INT J MENT HEALTH NU, V21, P236, DOI 10.1111/j.1447-0349.2012.00816.x
   Holt RIG, 2010, J PSYCHOPHARMACOL, V24, P867, DOI 10.1177/0269881109102788
   Holt R. I. G., 2010, Practical Diabetes International, V27, P79, DOI 10.1002/pdi.1451
   Johnstone R, 2009, J MENT HEALTH, V18, P523, DOI 10.3109/09638230903111114
   Kitzinger J., 1996, Qualitative Research in Health Care, P36
   Koivukangas J, 2010, SCHIZOPHR RES, V116, P152, DOI 10.1016/j.schres.2009.10.022
   Konrad K, 2010, HUM BRAIN MAPP, V31, P904, DOI 10.1002/hbm.21058
   KORAN LM, 1989, ARCH GEN PSYCHIAT, V46, P733
   Laursen TM, 2009, ARCH GEN PSYCHIAT, V66, P713, DOI 10.1001/archgenpsychiatry.2009.61
   Martínez-Arán A, 2004, BIPOLAR DISORD, V6, P224, DOI 10.1111/j.1399-5618.2004.00111.x
   Morgan, 1997, FOCUS GROUPS QUALITA
   Morrato EH, 2010, ARCH GEN PSYCHIAT, V67, P17, DOI 10.1001/archgenpsychiatry.2009.179
   National Board of Health and Welfare-Socialstyrelsen, 2012, SWED NAT BOARD HLTH
   National Institute of Public Health. Staten folkhalsoinstitut, 2012, STILL OH EN
   Pattij T, 2008, TRENDS PHARMACOL SCI, V29, P192, DOI 10.1016/j.tips.2008.01.002
   Peplau HE., 1952, INTERPERSONAL RELATI
   Philips R.J., 1934, British Medical Journal, V2, P363
   Robson D, 2007, INT J NURS STUD, V44, P457, DOI 10.1016/j.ijnurstu.2006.07.013
   Sandlund M., 2005, ATT LEVA PSYKISKT FU, P15
   SOU, 2006, SLUTB NAT PSYK AMB A
   SOU, 2006, UNGD STRESS PSYK OH
   Torres-Carbajo A., 2005, American Journal of Recreation Therapy, V4, P41
   Velligan DI, 2008, SCHIZOPHR RES, V102, P312, DOI 10.1016/j.schres.2008.02.005
   Velligan DI, 2009, SCHIZOPHRENIA BULL, V35, P884, DOI 10.1093/schbul/sbp075
   Verhaeghe N, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-657
   Verhaeghe N, 2011, INT J BEHAV NUTR PHY, V8, DOI 10.1186/1479-5868-8-28
   White Jane H, 2008, Issues Ment Health Nurs, V29, P1066, DOI 10.1080/01612840802319779
NR 46
TC 8
Z9 9
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1351-0126
EI 1365-2850
J9 J PSYCHIATR MENT HLT
JI J. Psychiatr. Ment. Health Nurs.
PD DEC
PY 2014
VL 21
IS 10
BP 924
EP 930
DI 10.1111/jpm.12175
PG 7
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA AU0OE
UT WOS:000345321900010
PM 25236866
DA 2025-06-11
ER

PT J
AU Chen, DD
   Zhang, H
   Wu, JJ
   Xue, ER
   Guo, PP
   Tang, LW
   Shao, J
   Cui, NQ
   Wang, XY
   Chen, LY
   Ye, ZH
AF Chen, Dandan
   Zhang, Hui
   Wu, Jingjie
   Xue, Erxu
   Guo, Pingping
   Tang, Leiwen
   Shao, Jing
   Cui, Nianqi
   Wang, Xiyi
   Chen, Liying
   Ye, Zhihong
TI Effects of an Individualized mHealth-Based Intervention on Health
   Behavior Change and Cardiovascular Risk Among People With Metabolic
   Syndrome Based on the Behavior Change Wheel: Quasi-Experimental Study
SO JOURNAL OF MEDICAL INTERNET RESEARCH
LA English
DT Article
DE metabolic syndrome; health behavior; cardiovascular risk; mobile health;
   behavior change wheel
ID PREVENTION; PREVALENCE; MANAGEMENT; REDUCE
AB Background: Metabolic syndrome (MetS) is a common public health challenge. Health-promoting behaviors such as diet and physical activity are central to preventing and controlling MetS. However, the adoption of diet and physical activity behaviors has always been challenging. An individualized mobile health (mHealth)-based intervention using the Behavior Change Wheel is promising in promoting health behavior change and reducing atherosclerotic cardiovascular disease (ASCVD) risk. However, the effects of this intervention are not well understood among people with MetS in mainland China.Objective: We aimed to evaluate the effects of the individualized mHealth-based intervention using the Behavior Change Wheel on behavior change and ASCVD risk in people with MetS.
   Methods: We conducted a quasi-experimental, nonrandomized study. Individuals with MetS were recruited from the health promotion center of a tertiary hospital in Zhejiang province, China. The study involved 138 adults with MetS, comprising a control group of 69 participants and an intervention group of 69 participants. All participants received health education regarding diet and physical activity. The intervention group additionally received a 12-week individualized intervention through a WeChat mini program and a telephone follow-up in the sixth week of the intervention. Primary outcomes included diet, physical activity behaviors, and ASCVD risk. Secondary outcomes included diet self-efficacy, physical activity self-efficacy, knowledge of MetS, quality of life, and the quality and efficiency of health management services. The Mann-Whitney U test and Wilcoxon signed rank test were primarily used for data analysis. Data analysis was conducted based on the intention-to-treat principle using SPSS (version 25.0; IBM Corp).
   Results: Baseline characteristics did not differ between the 2 groups. Compared with the control group, participants in the intervention group showed statistically significant improvements in diet behavior, physical activity behavior, diet self-efficacy, physical activity self-efficacy, knowledge of MetS, physical health, and mental health after a 12-week intervention (P=.04, P=.001, P=.04, P=.04, P=.001, P=.04, P=.04, and P<.05). The intervention group demonstrated a statistically significant improvement in outcomes from pre-to postintervention evaluations (P<.001, P=.03, P<.001, P=.04, P<.001, P<.001, and P<.001). The intervention also led to enhanced health management services and quality.
   Conclusions: The individualized mHealth-based intervention using the Behavior Change Wheel was effective in promoting diet and physical activity behaviors in patients with MetS. Nurses and other health care professionals may incorporate the intervention into their health promotion programs.
C1 [Chen, Dandan; Wu, Jingjie; Xue, Erxu; Chen, Liying; Ye, Zhihong] Zhejiang Univ, Affiliated Sir Run Run Shaw Hosp, Nursing Dept, Sch Med, Hangzhou, Peoples R China.
   [Zhang, Hui] Guizhou Prov Peoples Hosp, Dept Nursing, Guiyang, Peoples R China.
   [Guo, Pingping] Zhejiang Univ, Nursing Dept, Sch Med, Womens Hosp, Hangzhou, Peoples R China.
   [Tang, Leiwen] Zhejiang Univ, Inst Nursing Res, Sch Med, Hangzhou, Peoples R China.
   [Shao, Jing] Zhejiang Univ, Dept Nursing, Affiliated Hosp 4, Sch Med,Inst Nursing Res, Yiwu, Peoples R China.
   [Cui, Nianqi] Kunming Med Univ, Sch Nursing, Kunming, Peoples R China.
   [Wang, Xiyi] Shanghai Jiao Tong Univ, Sch Nursing, Shanghai, Peoples R China.
   [Ye, Zhihong] Zhejiang Univ, Affiliated Sir Run Run Shaw Hosp, Sch Med, Nursing Dept, 3 East Qingchun Rd, Hangzhou 310020, Peoples R China.
C3 Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang
   University; Kunming Medical University; Shanghai Jiao Tong University;
   Zhejiang University
RP Ye, ZH (corresponding author), Zhejiang Univ, Affiliated Sir Run Run Shaw Hosp, Sch Med, Nursing Dept, 3 East Qingchun Rd, Hangzhou 310020, Peoples R China.
EM yezh@zju.edu.cn
RI Wu, Jingjie/G-8274-2016; Wang, Xiyi/AAQ-2610-2021
OI Guo, Pingping/0000-0002-5091-9387; Wang, Xiyi/0000-0002-6470-8556; Tang,
   Leiwen/0000-0003-4058-0161; Cui, Nianqi/0000-0002-7963-4887
FU National Social Science Fund of China [20BGL275]
FX Acknowledgments The authors express their sincere gratitude to the
   participating hospital and all individuals with metabolic syndrome. This
   study was supported by the National Social Science Fund of China
   (20BGL275) . Generative artificial intelligence was not used in any
   portion of the manuscript writing.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alkhulaifi F, 2022, NUTRIENTS, V14, DOI 10.3390/nu14091719
   Almeda-Valdes P, 2019, CURR MED CHEM, V26, P3613, DOI 10.2174/0929867324666170518095316
   Aucoin M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124418
   Azar KMJ, 2016, J MED INTERNET RES, V18, DOI 10.2196/jmir.5143
   Becker H., 1993, HLTH VALUES, V17, P42
   Beltrán-Sánchez H, 2013, J AM COLL CARDIOL, V62, P697, DOI 10.1016/j.jacc.2013.05.064
   [曹文君 Cao Wenjun], 2016, [中华疾病控制杂志, Chinese Journal of Disease Control & Prevention], V20, P286
   Castro-Barquero S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12102983
   Celis-Morales C, 2017, INT J EPIDEMIOL, V46, P578, DOI 10.1093/ije/dyw186
   Changhao J, 2014, Adv Psychol Sci, V22, P1889, DOI [10.3724/SP.J.1042.2014.01889, DOI 10.3724/SP.J.1042.2014.01889]
   Chen DD, 2022, BMC PUBLIC HEALTH, V22, DOI 10.1186/s12889-022-14129-1
   Chen DD, 2023, EUR J CARDIOVASC NUR, V22, P193, DOI 10.1093/eurjcn/zvac034
   Chen Dandan, 2022, Zhejiang Da Xue Xue Bao Yi Xue Ban, V51, P27, DOI 10.3724/zdxbyxb-2021-0378
   Chen DD, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2020-036927
   Delavari A, 2009, DIABETES CARE, V32, P1092, DOI 10.2337/dc08-1800
   Des Jarlais DC, 2004, AM J PUBLIC HEALTH, V94, P361, DOI 10.2105/AJPH.94.3.361
   Dongxing G, 2016, Chin J Health Inf Manag, V8, P87, DOI [10.3969/j.issn.1672-5166.2021.03.023, DOI 10.3969/J.ISSN.1672-5166.2021.03.023]
   Fugui L, 2019, The influence of physical activity on emotion: the mediation of neuroticism regulation and self-efficacy
   Fujiyoshi A, 2011, J EVAL CLIN PRACT, V17, P78, DOI 10.1111/j.1365-2753.2010.01371.x
   Gallardo-Alfaro L, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041013
   Grundy SM, 2016, TRENDS CARDIOVAS MED, V26, P364, DOI 10.1016/j.tcm.2015.10.004
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Gu Dongfeng, 2020, Zhonghua Yufang Yixue Zazhi, V54, P256, DOI 10.3760/cma.j.issn.0253-9624.2020.03.006
   Jacka FN, 2017, BMC MED, V15, DOI 10.1186/s12916-017-0791-y
   Jimenez G, 2019, JMIR MHEALTH UHEALTH, V7, DOI 10.2196/11848
   Lam CLK, 2005, QUAL LIFE RES, V14, P539, DOI 10.1007/s11136-004-0704-3
   Lau Y, 2020, PREV MED, V132, DOI 10.1016/j.ypmed.2020.106001
   Lehtisalo J, 2022, EUR HEART J, V43, P2054, DOI 10.1093/eurheartj/ehab922
   Lihua W, 2016, Evaluation of the comprehensive intervention effect on metabolic syndrome in workers of a certain steel group
   Lu YT, 2022, INT J NURS PRACT, V28, DOI 10.1111/ijn.13002
   Ma JK, 2021, TRANSL BEHAV MED, V11, P2174, DOI 10.1093/tbm/ibab106
   Marcos-Delgado A, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18030887
   McKay FH, 2018, J TELEMED TELECARE, V24, P22, DOI 10.1177/1357633X16673538
   Michie S., 2014, ABC BEHAV CHANGE THE
   Michie S, 2011, IMPLEMENT SCI, V6, DOI 10.1186/1748-5908-6-42
   Ni ZH, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0278190
   Nilsson PM, 2019, EUR J PREV CARDIOL, V26, P33, DOI 10.1177/2047487319886404
   Oh B, 2015, JMIR MHEALTH UHEALTH, V3, DOI 10.2196/mhealth.4222
   Ordovas JM, 2018, BMJ-BRIT MED J, V361, DOI 10.1136/bmj.k2173
   Parletta N, 2019, NUTR NEUROSCI, V22, P474, DOI 10.1080/1028415X.2017.1411320
   Pawelczyk T, 2021, SCHIZOPHR RES, V230, P61, DOI 10.1016/j.schres.2021.02.012
   Peiris CL, 2021, REV ENDOCR METAB DIS, V22, P877, DOI 10.1007/s11154-021-09644-2
   Pérez-Martínez P, 2017, NUTR REV, V75, P307, DOI 10.1093/nutrit/nux014
   Rautio N, 2015, EUR J CARDIOVASC NUR, V14, P145, DOI 10.1177/1474515114521713
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sayón-Orea C, 2019, JAMA-J AM MED ASSOC, V322, P1486, DOI 10.1001/jama.2019.14630
   Scholze J, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-529
   Sequi-Dominguez I, 2020, J MED INTERNET RES, V22, DOI 10.2196/17790
   Tang Leiwen, 2022, Zhejiang Da Xue Xue Bao Yi Xue Ban, V51, P115, DOI 10.3724/zdxbyxb-2021-0380
   Tekkesin AI, 2021, ATHEROSCLEROSIS, V319, P21, DOI 10.1016/j.atherosclerosis.2020.12.020
   Thompson PD, 2003, ARTERIOSCL THROM VAS, V23, pE42, DOI 10.1161/01.ATV.0000089628.63625.D4
   Tucker G, 2010, QUAL LIFE RES, V19, P1069, DOI 10.1007/s11136-010-9658-9
   van Namen M, 2019, METABOLISM, V101, DOI 10.1016/j.metabol.2019.153988
   Wang Q, 2022, FRONT PUBLIC HEALTH, V10, DOI 10.3389/fpubh.2022.929043
   Wong EML, 2023, J NURS SCHOLARSHIP, V55, P936, DOI 10.1111/jnu.12883
   Xiaoqing F, 2019, Evaluation of the effectiveness of the O2O health management service process for middle-aged and young people with hypertension in the community
   Yang XL, 2016, CIRCULATION, V134, P1430, DOI 10.1161/CIRCULATIONAHA.116.022367
   Yao F, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124475
   Zhang JJ, 2021, DIABETOL METAB SYNDR, V13, DOI 10.1186/s13098-021-00627-6
   Zhang X, 2023, J MED INTERNET RES, V25, DOI 10.2196/41298
   Zheng XJ, 2020, INT J NURS STUD, V109, DOI 10.1016/j.ijnurstu.2020.103638
NR 62
TC 4
Z9 4
U1 3
U2 32
PU JMIR PUBLICATIONS, INC
PI TORONTO
PA 130 QUEENS QUAY East, Unit 1100, TORONTO, ON M5A 0P6, CANADA
SN 1438-8871
J9 J MED INTERNET RES
JI J. Med. Internet Res.
PD NOV 29
PY 2023
VL 25
AR e49257
DI 10.2196/49257
PG 17
WC Health Care Sciences & Services; Medical Informatics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; Medical Informatics
GA AA1L0
UT WOS:001115638000001
PM 38019579
OA gold
DA 2025-06-11
ER

PT J
AU dos Santos, JL
   de Quadros, A
   Weschenfelder, C
   Garofallo, SB
   Marcadenti, A
AF dos Santos, Julia Lorenzon
   de Quadros, Alexandre Schaan
   Weschenfelder, Camila
   Garofallo, Silvia Bueno
   Marcadenti, Aline
TI Oxidative Stress Biomarkers, Nut-Related Antioxidants, and
   Cardiovascular Disease
SO NUTRIENTS
LA English
DT Review
DE oxidative stress; antioxidants; nuts; cardiovascular diseases
ID CORONARY-HEART-DISEASE; CHEMICAL-COMPOSITION; METABOLIC SYNDROME;
   PISTACHIO NUTS; NITRIC-OXIDE; VITAMIN-E; CONSUMPTION; INFLAMMATION;
   BRAZIL; ALMONDS
AB Atherosclerosis is related to fat accumulation in the arterial walls and vascular stiffening, and results in acute coronary syndrome which is commonly associated with acute myocardial infarction. Oxidative stress participates in the pathogenesis of atherosclerosis. Thus, the inclusion of food sources of dietary antioxidants, such as different kinds of nuts, may improve biomarkers related to oxidative stress, contributing to a possible reduction in atherosclerosis progression. This article has briefly highlighted the interaction between oxidative stress, atherosclerosis, and cardiovascular disease, in addition to the effect of the consumption of different nuts and related dietary antioxidants-like polyphenols and vitamin E-on biomarkers of oxidative stress in primary and secondary cardiovascular prevention. Studies in vitro suggest that nuts may exert antioxidant effects by DNA repair mechanisms, lipid peroxidation prevention, modulation of the signaling pathways, and inhibition of the MAPK pathways through the suppression of NF-kappa B and activation of the Nrf2 pathways. Studies conducted in animal models showed the ability of dietary nuts in improving biomarkers of oxidative stress, such as oxLDL and GPx. However, clinical trials in humans have not been conclusive, especially with regards to the secondary prevention of cardiovascular disease.
C1 [dos Santos, Julia Lorenzon; de Quadros, Alexandre Schaan; Weschenfelder, Camila; Garofallo, Silvia Bueno; Marcadenti, Aline] Univ Fdn Cardiol IC FUC, Inst Cardiol Rio Grande Sul, Grad Program Hlth Sci Cardiol, Princesa Isabel Ave 395, BR-90040371 Porto Alegre, RS, Brazil.
   [Marcadenti, Aline] Coracao Hosp IP HCor, HCor Res Inst, Abilio Soares St 250, BR-0400405 Sao Paulo, Brazil.
C3 Fundacao Universitaria de Cardiologia; Hospital do Coracao - HCor
RP Marcadenti, A (corresponding author), Univ Fdn Cardiol IC FUC, Inst Cardiol Rio Grande Sul, Grad Program Hlth Sci Cardiol, Princesa Isabel Ave 395, BR-90040371 Porto Alegre, RS, Brazil.; Marcadenti, A (corresponding author), Coracao Hosp IP HCor, HCor Res Inst, Abilio Soares St 250, BR-0400405 Sao Paulo, Brazil.
EM julia.lorenzon@gmail.com; consult.asq@gmail.com; camilawesche@gmail.com;
   silviagarofallo@hotmail.com; marcadenti.aline@gmail.com
RI de Quadros, Alexandre/AAJ-5622-2021; Marcadenti, Aline/A-8085-2012
OI Marcadenti, Aline/0000-0003-1994-4610; Weschenfelder,
   Camila/0000-0002-9470-2569
CR Acosta JC, 2013, NAT CELL BIOL, V15, P978, DOI 10.1038/ncb2784
   Alasalvar C, 2015, BRIT J NUTR, V113, pS68, DOI 10.1017/S0007114514003729
   Alasalvar C, 2009, EUR J LIPID SCI TECH, V111, P1056, DOI 10.1002/ejlt.200900098
   Alturfan AA, 2009, FOLIA BIOL-PRAGUE, V55, P132
   Amaral JS, 2005, J AGR FOOD CHEM, V53, P5467, DOI 10.1021/jf050342u
   Ambrose John A, 2015, F1000Prime Rep, V7, P08, DOI 10.12703/P7-08
   Anderson KJ, 2001, J NUTR, V131, P2837, DOI 10.1093/jn/131.11.2837
   [Anonymous], 2013, USDA NAT NUTR DAT ST
   [Anonymous], PLANT SYSTEMATICS AP
   Anselmo Natassia Alberici, 2018, Braz. J. Nephrol., V40, P10, DOI [10.1590/1678-46a85-jbn-3819, 10.1590/1678-46a85-JBN-3819]
   Arnett DK, 2019, CIRCULATION, V140, pE563, DOI [10.1016/j.jacc.2019.03.009, 10.1016/j.jacc.2019.03.010, 10.1161/CIR.0000000000000678, 10.1161/CIR.0000000000000677]
   Bao Y, 2013, NEW ENGL J MED, V369, P2001, DOI 10.1056/NEJMoa1307352
   Bento APN, 2014, NUTR METAB CARDIOVAS, V24, P1330, DOI 10.1016/j.numecd.2014.07.002
   Berryman CE, 2013, J NUTR, V143, P788, DOI 10.3945/jn.112.170993
   Bitok E, 2018, PROG CARDIOVASC DIS, V61, P33, DOI 10.1016/j.pcad.2018.05.003
   Bolling BW, 2011, NUTR RES REV, V24, P244, DOI 10.1017/S095442241100014X
   Bolling BW, 2010, ASIA PAC J CLIN NUTR, V19, P117
   Campisi J, 2005, CELL, V120, P513, DOI 10.1016/j.cell.2005.02.003
   Cardoso BR, 2017, FOOD RES INT, V100, P9, DOI 10.1016/j.foodres.2017.08.036
   Chaalal M, 2019, ACTA ALIMENT HUNG, V48, P125, DOI 10.1556/066.2018.0009
   Chen CYO, 2015, NUTR J, V14, DOI 10.1186/s12937-015-0049-5
   Choi Y, 2016, J NUTR BIOCHEM, V38, P70, DOI 10.1016/j.jnutbio.2016.08.013
   Darvish D.R., 2019, INT J ENDOCRINOL MET, V17
   Domínguez-Avila JA, 2015, FOOD CHEM, V168, P529, DOI 10.1016/j.foodchem.2014.07.092
   Dugo G, 2003, J AGR FOOD CHEM, V51, P3722, DOI 10.1021/jf021256m
   Ellsworth JL, 2001, NUTR METAB CARDIOVAS, V11, P372
   Estruch R, 2018, NEW ENGL J MED, V378, DOI [10.1056/NEJMoa1800389, 10.1056/NEJMoa1200303, 10.1056/nejmoa1800389]
   Barbosa KBF, 2010, REV NUTR, V23, P629, DOI 10.1590/S1415-52732010000400013
   Förstermann U, 2008, NAT CLIN PRACT CARD, V5, P338, DOI 10.1038/ncpcardio1211
   Förstermann U, 2010, PFLUG ARCH EUR J PHY, V459, P923, DOI 10.1007/s00424-010-0808-2
   FRASER GE, 1992, ARCH INTERN MED, V152, P1416, DOI 10.1001/archinte.152.7.1416
   Freitas J. B., 2012, Food and Nutrition Sciences, V3, P857, DOI 10.4236/fns.2012.36114
   Freitas JB, 2010, REV NUTR, V23, P269, DOI 10.1590/S1415-52732010000200010
   Gardner SE, 2015, ARTERIOSCL THROM VAS, V35, P1963, DOI 10.1161/ATVBAHA.115.305896
   Glaudemans AWJM, 2010, EUR J NUCL MED MOL I, V37, P2381, DOI 10.1007/s00259-010-1406-4
   Guaraldi F, 2018, J NUTR BIOCHEM, V57, P206, DOI 10.1016/j.jnutbio.2018.03.012
   Gulati S, 2014, NUTRITION, V30, P192, DOI 10.1016/j.nut.2013.08.005
   Hatch EvelynM., 1933, SELECTION LETT LEWIS, P1
   Hong MY, 2018, MOLECULES, V23, DOI 10.3390/molecules23123126
   Hshieh TT, 2015, AM J CLIN NUTR, V101, P407, DOI 10.3945/ajcn.114.099846
   Huguenin GVB, 2015, NUTR J, V14, DOI 10.1186/s12937-015-0043-y
   Kim HS, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/2594703
   Kim Y, 2017, NUTRIENTS, V9, DOI 10.3390/nu9111271
   Köksal AH, 2006, FOOD CHEM, V99, P509, DOI 10.1016/j.foodchem.2005.08.013
   Laubertová L, 2015, EUR J NUTR, V54, P291, DOI 10.1007/s00394-014-0710-3
   Lee YJ, 2014, NUTR RES, V34, P814, DOI 10.1016/j.nutres.2014.08.011
   Lefer DJ, 2000, AM J MED, V109, P315, DOI 10.1016/S0002-9343(00)00467-8
   Li HG, 2014, ATHEROSCLEROSIS, V237, P208, DOI 10.1016/j.atherosclerosis.2014.09.001
   Liguori I, 2018, CLIN INTERV AGING, V13, P757, DOI 10.2147/CIA.S158513
   Lippi G, 2016, INT J CARDIOL, V215, P20, DOI 10.1016/j.ijcard.2016.04.045
   Liu JF, 2013, EUR J NUTR, V52, P927, DOI 10.1007/s00394-012-0400-y
   López-Uriarte P, 2010, CLIN NUTR, V29, P373, DOI 10.1016/j.clnu.2009.12.008
   Lux S, 2012, BRIT J NUTR, V108, P1177, DOI 10.1017/S0007114511006647
   Macedo TJS, 2017, ZYGOTE, V25, P434, DOI [10.1017/S0967199417000193, 10.1017/s0967199417000193]
   de Souza RGM, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081750
   de Souza RGM, 2017, NUTRIENTS, V9, DOI 10.3390/nu9121311
   Maranhao PA, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-32
   Miraliakbari H, 2008, J FOOD LIPIDS, V15, P81, DOI 10.1111/j.1745-4522.2007.00104.x
   Morel A, 2014, PLATELETS, V25, P75, DOI 10.3109/09537104.2013.769511
   Paterniti I, 2017, NUTRIENTS, V9, DOI 10.3390/nu9080915
   Pérez-Jiménez J, 2010, EUR J CLIN NUTR, V64, pS112, DOI 10.1038/ejcn.2010.221
   Rapola JM, 1997, LANCET, V349, P1715, DOI 10.1016/S0140-6736(97)01234-8
   Ryan E, 2006, INT J FOOD SCI NUTR, V57, P219, DOI 10.1080/09637480600768077
   Sakakura K, 2013, HEART LUNG CIRC, V22, P399, DOI 10.1016/j.hlc.2013.03.001
   Sánchez-González C, 2017, CRIT REV FOOD SCI, V57, P3373, DOI 10.1080/10408398.2015.1126218
   Sheng JY, 2019, J AGR FOOD CHEM, V67, P3305, DOI 10.1021/acs.jafc.8b05722
   Shin EC, 2009, J AGR FOOD CHEM, V57, P10289, DOI 10.1021/jf9029546
   Duarte GBS, 2019, NUTRITION, V63-64, P162, DOI 10.1016/j.nut.2019.02.009
   Siti HN, 2015, VASC PHARMACOL, V71, P40, DOI 10.1016/j.vph.2015.03.005
   Stephens NG, 1996, LANCET, V347, P781, DOI 10.1016/S0140-6736(96)90866-1
   Stevens-Barrón JC, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102303
   Stockler-Pinto MB, 2014, BIOL TRACE ELEM RES, V158, P105, DOI 10.1007/s12011-014-9904-z
   Sureda A, 2016, MOL NUTR FOOD RES, V60, P2654, DOI 10.1002/mnfr.201600450
   Surra JC, 2013, BRIT J NUTR, V109, P202, DOI 10.1017/S000711451200092X
   Thomazella MCD, 2011, AM J CARDIOL, V108, P1523, DOI 10.1016/j.amjcard.2011.07.008
   Valagussa F, 1999, LANCET, V354, P447, DOI 10.1016/S0140-6736(99)07072-5
   Venkatachalam M, 2006, J AGR FOOD CHEM, V54, P4705, DOI 10.1021/jf0606959
   Vera R, 2009, REV BRAS FRUTIC, V31, P112, DOI 10.1590/S0100-29452009000100017
   Wang T, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092153
   World Health Organization, TOP 10 CAUS DEATH
   Yang L., 2018, BioMed Research International, P1, DOI DOI 10.1155/2018/8584136
   Zamora-Ros R, 2013, NUTR METAB CARDIOVAS, V23, P1167, DOI 10.1016/j.numecd.2012.12.008
NR 82
TC 78
Z9 80
U1 5
U2 37
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2020
VL 12
IS 3
AR 682
DI 10.3390/nu12030682
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA LL8VB
UT WOS:000531831000091
PM 32138220
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Morais, JBS
   Severo, JS
   dos Santos, LR
   Melo, SRD
   Santos, RD
   de Oliveira, ARS
   Cruz, KJC
   Marreiro, DD
AF Silva Morais, Jennifer Beatriz
   Severo, Juliana Soares
   dos Santos, Loanne Rocha
   de Sousa Melo, Stefany Rodrigues
   Santos, Raisa de Oliveira
   Soares de Oliveira, Ana Raquel
   Climaco Cruz, Kyria Jayanne
   Marreiro, Dilina do Nascimento
TI Role of Magnesium in Oxidative Stress in Individuals with Obesity
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Magnesium; Oxidative stress; Malondialdehyde; Superoxide dismutase;
   Glutathione peroxidase; Reactive oxygen species; Inflammation; Obesity
ID INSULIN-RESISTANCE; ADIPOSE-TISSUE; BIOCHEMICAL PARAMETERS;
   LIPID-PEROXIDATION; METABOLIC SYNDROME; INFLAMMATION; MECHANISMS;
   SUPPLEMENTATION; DEFICIENCY; DYSREGULATION
AB Adipose tissue is considered an endocrine organ that promotes excessive production of reactive oxygen species when in excess, thus contributing to lipid peroxidation. Magnesium deficiency contributes to the development of oxidative stress in obese individuals, as this mineral plays a role as an antioxidant, participates as a cofactor of several enzymes, maintains cell membrane stability and mitigates the effects of oxidative stress. The objective of this review is to bring together updated information on the participation of magnesium in the oxidative stress present in obesity. We conducted a search of articles published in the PubMed, SciELO and LILACS databases, using the keywords 'magnesium', 'oxidative stress', 'malondialdehyde', 'superoxide dismutase', 'glutathione peroxidase', 'reactive oxygen species', 'inflammation' and 'obesity'. The studies show that obese subjects have low serum concentrations of magnesium, as well as high concentrations of oxidative stress marker in these individuals. Furthermore, it is evident that the adequate intake of magnesium contributes to its appropriate homeostasis in the body. Thus, this review of current research can help define the need for intervention with supplementation of this mineral for the prevention and treatment of disorders associated with this chronic disease.
C1 [Silva Morais, Jennifer Beatriz; Severo, Juliana Soares; dos Santos, Loanne Rocha; de Sousa Melo, Stefany Rodrigues; Santos, Raisa de Oliveira; Soares de Oliveira, Ana Raquel; Climaco Cruz, Kyria Jayanne; Marreiro, Dilina do Nascimento] Univ Fed Piaui, Dept Nutr, Campus Minister Petronio Portela, BR-64048320 Teresina, Piaui, Brazil.
C3 Universidade Federal do Piaui
RP Marreiro, DD (corresponding author), Univ Fed Piaui, Dept Nutr, Campus Minister Petronio Portela, BR-64048320 Teresina, Piaui, Brazil.
EM dilina.marreiro@gmail.com
RI CRUZ, KYRIA/LOQ-9371-2024; Severo, Juliana/C-5152-2018
OI Cruz, Kyria Jayanne/0000-0002-4489-702X; Severo,
   Juliana/0000-0002-1771-7871
CR García EA, 2012, ACTA BIOQUIM CLIN L, V46, P183
   [Anonymous], 2011, Rev. Bras. Clin. Med
   Bae HC, 2011, MOL CELL TOXICOL, V7, P333, DOI 10.1007/s13273-011-0042-9
   Barbagallo M, 2010, CURR PHARM DESIGN, V16, P832, DOI 10.2174/138161210790883679
   Belin RJ, 2007, MAGNESIUM RES, V20, P107
   Beltowski J, 2012, CLIN EXP PHARMACOL P, V39, P168, DOI 10.1111/j.1440-1681.2011.05623.x
   Bertinato J, 2015, FOOD NUTR RES, V59, DOI 10.3402/fnr.v59.25974
   Bryan HK, 2013, BIOCHEM PHARMACOL, V85, P705, DOI 10.1016/j.bcp.2012.11.016
   CALVIELLO G, 1994, BIOCHEM MOL BIOL INT, V32, P903
   Çelik N, 2011, J PEDIATR ENDOCR MET, V24, P675, DOI 10.1515/JPEM.2011.255
   Chen HC, 2012, BIOCHEM J, V445, P441, DOI 10.1042/BJ20120248
   Chen X, 2014, FREE RADICAL BIO MED, V69, P77, DOI 10.1016/j.freeradbiomed.2014.01.011
   Cruz KJC, 2014, BIOL TRACE ELEM RES, V160, P305, DOI 10.1007/s12011-014-0044-2
   Cocate PG, 2014, NUTRITION, V30, P660, DOI 10.1016/j.nut.2013.10.015
   Codoñer-Franch P, 2010, INT J PEDIATR OBES, V5, P56, DOI 10.3109/17477160903055945
   de Baaij JHF, 2015, PHYSIOL REV, V95, P1, DOI 10.1152/physrev.00012.2014
   Exley MA, 2014, J ENDOCRINOL, V223, pR41, DOI 10.1530/JOE-13-0516
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   França Bruna Karoline, 2013, J Port Gastrenterol., V20, P199
   Galic S, 2010, MOL CELL ENDOCRINOL, V316, P129, DOI 10.1016/j.mce.2009.08.018
   Gobato RC, 2014, SURG OBES RELAT DIS, V10, P944, DOI 10.1016/j.soard.2014.05.011
   Gottlieb MGV, 2010, SCI MED, V21, P69
   Hans CP, 2003, MAGNESIUM RES, V16, P13
   Inoue H, 2014, FREE RADICAL BIO MED, V72, P257, DOI 10.1016/j.freeradbiomed.2014.04.015
   Jastrzebska-Mierzynska M, 2012, VIDEOSURGERY MINIINV, V7, P156, DOI 10.5114/wiitm.2011.27581
   Khan M, 2014, SCIENTIFICA, V2014, DOI 10.1155/2014/328592
   Kolisek M, 2015, CLIN SCI, V129, P1143, DOI 10.1042/CS20150355
   Kostellow AB, 2004, ATHEROSCLEROSIS, V175, P15, DOI 10.1016/j.atherosclerosis.2004.01.040
   Latham JR, 2009, DIABETES, V58, P2656, DOI 10.2337/db08-1763
   Lecube A, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030599
   Li YH, 2015, BBA-GEN SUBJECTS, V1850, P813, DOI 10.1016/j.bbagen.2015.01.007
   López-Jaramillo P, 2014, HORM MOL BIOL CLIN I, V18, P37, DOI 10.1515/hmbci-2013-0053
   Maier JAM, 2012, CLIN SCI, V122, P397, DOI 10.1042/CS20110506
   Marchesi C, 2009, HYPERTENSION, V54, P1384, DOI 10.1161/HYPERTENSIONAHA.109.138305
   Matsuda M, 2013, OBES RES CLIN PRACT, V7, pE330, DOI 10.1016/j.orcp.2013.05.004
   Mazur A, 2007, ARCH BIOCHEM BIOPHYS, V458, P48, DOI 10.1016/j.abb.2006.03.031
   Molica F, 2015, THROMB HAEMOSTASIS, V113, P553, DOI 10.1160/TH14-06-0513
   Mooren FC, 2011, DIABETES OBES METAB, V13, P281, DOI 10.1111/j.1463-1326.2010.01332.x
   Murdolo G, 2013, BIOCHIMIE, V95, P585, DOI 10.1016/j.biochi.2012.12.014
   Nielsen FH, 2010, NUTR REV, V68, P333, DOI 10.1111/j.1753-4887.2010.00293.x
   Niranjan G, 2014, Int J Biomed Sci, V10, P118
   Oteiza PI, 2012, FREE RADICAL BIO MED, V53, P1748, DOI 10.1016/j.freeradbiomed.2012.08.568
   Patel M.D., 2012, Int. J. Sci. Res., V3, P229, DOI [10.15373/22778179/MARCH2014/77, DOI 10.15373/22778179/MARCH2014/77]
   Ribeiro MCP, 2013, MAGNESIUM RES, V26, P32, DOI 10.1684/mrh.2013.0334
   Rayssiguier Y, 2010, MAGNESIUM RES, V23, P73, DOI 10.1684/mrh.2010.0208
   Rochette L, 2013, PHARMACOL THERAPEUT, V140, P239, DOI 10.1016/j.pharmthera.2013.07.004
   Sampaio FA, 2014, NUTR HOSP, V30, P570, DOI 10.3305/nh.2014.30.3.7333
   Savini I, 2013, INT J MOL SCI, V14, P10497, DOI 10.3390/ijms140510497
   Scherer T, 2012, J BIOL CHEM, V287, P33061, DOI 10.1074/jbc.M111.307348
   Silva PA., 2014, J DIABETES METAB, V5, P1000347, DOI [10.4172/2155-6156.1000347, DOI 10.4172/2155-6156.1000347]
   de Oliveira ARS, 2015, BIOL TRACE ELEM RES, V168, P296, DOI 10.1007/s12011-015-0358-8
   Song CH, 2007, EUR J CLIN NUTR, V61, P682, DOI 10.1038/sj.ejcn.1602568
   Su LT, 2010, J MOL BIOL, V396, P858, DOI 10.1016/j.jmb.2010.01.014
   Suliburska J, 2011, BIOL TRACE ELEM RES, V139, P137, DOI 10.1007/s12011-010-8650-0
   Tchoukalova YD, 2010, P NATL ACAD SCI USA, V107, P18226, DOI 10.1073/pnas.1005259107
   Venco P, 2015, FRONT GENET, V6, DOI 10.3389/fgene.2015.00185
   Warolin J, 2014, PEDIATR OBES, V9, P43, DOI 10.1111/j.2047-6310.2012.00135.x
   Weglicki WB, 2012, ANNU REV NUTR, V32, P55, DOI 10.1146/annurev-nutr-071811-150656
   Weglicki WB, 2011, AM J MED SCI, V342, P125, DOI 10.1097/MAJ.0b013e318222e88c
NR 59
TC 92
Z9 101
U1 1
U2 26
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD MAR
PY 2017
VL 176
IS 1
BP 20
EP 26
DI 10.1007/s12011-016-0793-1
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA EL2JR
UT WOS:000394446400003
PM 27444303
DA 2025-06-11
ER

PT J
AU Im, HJ
   Chu, MK
   Yang, KI
   Kim, WJ
   Hwang, I
   Yoon, JE
   Oh, D
   Thomas, RJ
   Yun, CH
AF Im, Hee-Jin
   Chu, Min Kyung
   Yang, Kwang Ik
   Kim, Won-Joo
   Hwang, Inha
   Yoon, Jee-Eun
   Oh, Dana
   Thomas, Robert J. J.
   Yun, Chang-Ho
TI The association between social jetlag and depression is independent of
   sleep debt
SO SLEEP AND BREATHING
LA English
DT Article
DE Sleep-corrected social jetlag; Depression; Sleep debt; Weekend sleep
   extension
ID CATCH-UP SLEEP; METABOLIC SYNDROME; DURATION; CHRONOTYPE; HYPERTENSION;
   ENDOCRINE; MORTALITY; LIFE; LAG
AB ObjectivesTo investigate whether the association between SJLsc (sleep-corrected social jetlag) and depressive mood is significant and independent of sleep debt.MethodsParticipants from the general adult population were interviewed using structured questionnaires on sleep duration, weekday/weekend sleep schedules, and depressive mood (Patient Health Questionnaire-9). Social jetlag (SJL) was measured by SJLsc and standard SJL (SJLs). SJLs was the absolute difference between mid-sleep time on free days (MSF) and workdays (MSW). For SJLsc, both MSF and MSW were adjusted for average sleep duration across the week according to the direction of sleep debt. Sleep debt was defined by sleep extension on free days. The association of SJL with depression was investigated, and covariates included age, sex, sociodemographic factors, insomnia symptoms, sleep duration, and sleep debt.ResultsA total of 1982 individuals (1089 men; age 43.1 +/- 14.4 years) were analyzed. SJL was present in 24.6% measured by SJLsc and 51.0% by SJLs. SJLsc and SJLs were significantly associated with depressive mood (r = 0.06, P = 0.02; r = 0.06, P = 0.01, respectively), independent of sleep debt. Sleep debt was also associated with depression (r = 0.07, P < 0.01).ConclusionsBy adopting sleep-corrected formula for SJL, this study found that misaligned and insufficient sleep, at levels occurring in routine social life, can negatively affect mood. Minimizing social jetlag and sleep deprivation may promote individual psychological well-being.
C1 [Im, Hee-Jin] Hallym Univ, Dongtan Sacred Heart Hosp, Dept Neurol, Coll Med, Hwaseong, South Korea.
   [Chu, Min Kyung] Yonsei Univ, Severance Hosp, Coll Med, Dept Neurol, Seoul, South Korea.
   [Yang, Kwang Ik] Soonchunhyang Univ, Cheonan Hosp, Sleep Disorders Ctr, Dept Neurol,Coll Med, Cheonan, South Korea.
   [Kim, Won-Joo] Yonsei Univ, Gangnam Severance Hosp, Coll Med, Dept Neurol, Seoul, South Korea.
   [Hwang, Inha; Yun, Chang-Ho] Seoul Natl Univ, Seoul Natl Univ Bundang Hosp, Dept Neurol, 82 Gumi Ro,173 Beon Gil, Seongnam 13620, Gyeonggi, South Korea.
   [Hwang, Inha; Yun, Chang-Ho] Seoul Natl Univ, Coll Med, 82 Gumi Ro,173 Beon Gil, Seongnam 13620, Gyeonggi, South Korea.
   [Yoon, Jee-Eun] Bucheon Soonchunhyang Univ Hosp, Dept Neurol, Bucheon, South Korea.
   [Oh, Dana] Seoul Med Ctr, Dept Neurol, Seoul, South Korea.
   [Thomas, Robert J. J.] Beth Israel Deaconess Med Ctr, Dept Med, Div Pulm Crit Care & Sleep Med, Boston, MA USA.
C3 Hallym University; Yonsei University; Yonsei University Health System;
   Soonchunhyang University; Yonsei University; Yonsei University Health
   System; Seoul National University (SNU); Seoul National University
   Hospital; Seoul National University (SNU); Soonchunhyang University;
   Seoul Medical Center; Harvard University; Harvard University Medical
   Affiliates; Beth Israel Deaconess Medical Center
RP Yun, CH (corresponding author), Seoul Natl Univ, Seoul Natl Univ Bundang Hosp, Dept Neurol, 82 Gumi Ro,173 Beon Gil, Seongnam 13620, Gyeonggi, South Korea.; Yun, CH (corresponding author), Seoul Natl Univ, Coll Med, 82 Gumi Ro,173 Beon Gil, Seongnam 13620, Gyeonggi, South Korea.
EM ych333@gmail.com
OI Chu, Min Kyung/0000-0001-6221-1346; Kim, Won-Joo/0000-0002-5850-010X;
   Yun, Chang-Ho/0000-0003-2204-8067
FU Korean Neurological Association, Republic of Korea [KNA-10-MI-03]
FX This study was supported by grants from the Korean Neurological
   Association (KNA-10-MI-03), Republic of Korea
CR Amagai Y, 2004, J EPIDEMIOL, V14, P124, DOI 10.2188/jea.14.124
   Bastien CH, 2001, SLEEP MED, V2, P297, DOI 10.1016/S1389-9457(00)00065-4
   de Souza CM, 2014, CHRONOBIOL INT, V31, P199, DOI 10.3109/07420528.2013.838575
   Depner CM, 2019, CURR BIOL, V29, P957, DOI 10.1016/j.cub.2019.01.069
   Gangwisch JE, 2010, SLEEP, V33, P956, DOI 10.1093/sleep/33.7.956
   Gottlieb DJ, 2006, SLEEP, V29, P1009, DOI 10.1093/sleep/29.8.1009
   Hall MH, 2008, SLEEP, V31, P635, DOI 10.1093/sleep/31.5.635
   Henderson SEM, 2019, CHRONOBIOL INT, V36, P1316, DOI 10.1080/07420528.2019.1636813
   Hwangbo Y, 2013, SLEEP MED, V14, P549, DOI 10.1016/j.sleep.2013.02.009
   Im HJ, 2017, SLEEP, V40, DOI 10.1093/sleep/zsx089
   Islam Z, 2020, SLEEP, V43, DOI 10.1093/sleep/zsz204
   Jankowski KS, 2017, CHRONOBIOL INT, V34, P531, DOI 10.1080/07420528.2017.1299162
   Juda M, 2013, J BIOL RHYTHM, V28, P141, DOI 10.1177/0748730412475042
   Keller LK, 2017, EUR CHILD ADOLES PSY, V26, P1233, DOI 10.1007/s00787-017-0977-z
   Kelly RM, 2020, SLEEP MED, V66, P1, DOI 10.1016/j.sleep.2019.07.023
   Killick R, 2015, CLIN ENDOCRINOL, V83, P498, DOI 10.1111/cen.12747
   Knapen SE, 2018, CHRONOBIOL INT, V35, P1, DOI 10.1080/07420528.2017.1374966
   Koopman ADM, 2017, J BIOL RHYTHM, V32, P359, DOI 10.1177/0748730417713572
   Korczak AL, 2008, BRAZ J MED BIOL RES, V41, P914, DOI 10.1590/S0100-879X2008005000047
   Kripke DF, 2002, ARCH GEN PSYCHIAT, V59, P131, DOI 10.1001/archpsyc.59.2.131
   Kroenke K, 2002, PSYCHIAT ANN, V32, P509, DOI 10.3928/0048-5713-20020901-06
   Levandovski R, 2011, CHRONOBIOL INT, V28, P771, DOI 10.3109/07420528.2011.602445
   Mathew GM, 2019, J BIOL RHYTHM, V34, P205, DOI 10.1177/0748730419828102
   Matthews KA, 2012, SLEEP, V35, P1353, DOI 10.5665/sleep.2112
   Min JH, 2023, J AFFECT DISORDERS, V323, P562, DOI 10.1016/j.jad.2022.12.010
   Okajima I, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18062908
   Parsons MJ, 2015, INT J OBESITY, V39, P842, DOI 10.1038/ijo.2014.201
   Randler C, 2012, J INDIVID DIFFER, V33, P186, DOI 10.1027/1614-0001/a000089
   Roenneberg T, 2003, J BIOL RHYTHM, V18, P80, DOI 10.1177/0748730402239679
   Roenneberg T, 2019, BIOLOGY-BASEL, V8, DOI 10.3390/biology8030054
   Roenneberg T, 2012, CURR BIOL, V22, P939, DOI 10.1016/j.cub.2012.03.038
   Roepke SE, 2010, NAT SCI SLEEP, V2, P213, DOI 10.2147/NSS.S12572
   Rutters F, 2014, J BIOL RHYTHM, V29, P377, DOI 10.1177/0748730414550199
   Spiegel K, 1999, LANCET, V354, P1435, DOI 10.1016/S0140-6736(99)01376-8
   Wittmann M, 2006, CHRONOBIOL INT, V23, P497, DOI 10.1080/07420520500545979
NR 35
TC 6
Z9 6
U1 3
U2 10
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1520-9512
EI 1522-1709
J9 SLEEP BREATH
JI Sleep Breath.
PD DEC
PY 2023
VL 27
IS 6
BP 2459
EP 2467
DI 10.1007/s11325-023-02849-6
EA MAY 2023
PG 9
WC Clinical Neurology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Respiratory System
GA Y4XX8
UT WOS:000987925000001
PM 37184756
DA 2025-06-11
ER

PT J
AU Akter, T
   Zahan, MS
   Nawal, N
   Rahman, MH
   Tanjum, TN
   Arafat, KI
   Moni, A
   Islam, MN
   Uddin, MJ
AF Akter, Tanzina
   Zahan, Md. Sarwar
   Nawal, Nafisa
   Rahman, Md. Hasanur
   Tanjum, Tayyabatun Nur
   Arafat, Kazi Ifthi
   Moni, Akhi
   Islam, Mohammad Nazrul
   Uddin, Md Jamal
TI Potentials of curcumin against polycystic ovary syndrome:
   Pharmacological insights and therapeutic promises
SO HELIYON
LA English
DT Review
DE PCOS; Hyperandrogenism; Oxidative stress; Insulin resistance;
   Inflammation; Hyperglycemia; Hyperlipidemia; Apoptosis
ID C-REACTIVE PROTEIN; CHRONIC KIDNEY-DISEASE; NECROSIS-FACTOR-ALPHA;
   KAPPA-B ACTIVATION; INSULIN-RESISTANCE; OXIDATIVE STRESS; SYNDROME PCOS;
   DOUBLE-BLIND; ANTHROPOMETRIC INDEXES; METABOLIC SYNDROME
AB Polycystic ovary syndrome (PCOS) is a common hormonal disorder among women (4%-20%) when the ovaries create abnormally high levels of androgens, the male sex hormones that are typically present in women in trace amounts. The primary characteristics of PCOS include oxidative stress, inflammation, hyperglycemia, hyperlipidemia, hyperandrogenism, and insulin resistance. Generally, metformin, spironolactone, eflornithine and oral contraceptives are used to treat PCOS, despite their several side effects. Therefore, finding a potential candidate for treating PCOS is necessary. Curcumin is a major active natural polyphenolic compound derived from turmeric (Curcuma longa). A substantial number of studies have shown that curcumin has antiinflammatory, anti-oxidative stress, antibacterial, and anti-apoptotic activities. In addition, curcumin reduces hyperglycemia, hyperlipidemia, hyperandrogenism, and insulin resistance in various conditions, including PCOS. The review highlighted the therapeutic aspects of curcumin against the pathophysiology of PCOS. We also offer a hypothesis to improve the development of medicines based on curcumin against PCOS.
C1 [Akter, Tanzina; Zahan, Md. Sarwar; Nawal, Nafisa; Rahman, Md. Hasanur; Tanjum, Tayyabatun Nur; Arafat, Kazi Ifthi; Moni, Akhi; Islam, Mohammad Nazrul; Uddin, Md Jamal] ABEx Biores Ctr, Dhaka 1230, Bangladesh.
   [Islam, Mohammad Nazrul] Sher E Bangla Agr Univ, Dept Biotechnol, Dhaka 1207, Bangladesh.
C3 Sher-e-Bangla Agricultural University (SAU)
RP Uddin, MJ (corresponding author), ABEx Biores Ctr, Dhaka 1230, Bangladesh.
EM hasan800920@gmail.com
RI Akter, Tanzina/ABG-6726-2021; Rahman, Hasanur/AAX-4023-2020; Zahan, Md.
   Sarwar/AFS-4089-2022; Uddin, Md Jamal/W-3434-2017; Islam, Mohammad
   Nazrul/JAN-7145-2023
OI Islam, Mohammad Nazrul/0000-0001-5692-3566; Arafat, Kazi
   Ifthi/0000-0002-0488-1429; Rahman, MD. Hasanur/0000-0001-9238-3149;
   Uddin, Md Jamal/0000-0003-2911-3255
CR Abdelazeem B, 2022, PHYTOTHER RES, V36, P22, DOI 10.1002/ptr.7274
   Abhari SMF, 2020, LIFE SCI, V249, DOI 10.1016/j.lfs.2020.117515
   Abuelezz Nermeen Z, 2021, J Exp Pharmacol, V13, P873, DOI 10.2147/JEP.S323962
   Abuelezz NZ, 2020, LIFE SCI, V256, DOI 10.1016/j.lfs.2020.118003
   Aggarwal BB, 2003, ANTICANCER RES, V23, P363
   Aggarwal BB, 2007, ADV EXP MED BIOL, V595, P1
   Aggarwal BB, 2010, ANNU REV NUTR, V30, P173, DOI 10.1146/annurev.nutr.012809.104755
   Akhi Moni Akhi Moni, 2018, Journal of Advanced Biotechnology and Experimental Therapeutics, V1, P78, DOI 10.5455/jabet.2018.d14
   Akinrinmade J. F., 2013, European Journal of Medicinal Plants, V3, P591
   Alibraheemi NAA, 2021, LAT AM J PHARM, V40, P179
   Alipourfard I, 2019, MEDIAT INFLAMM, V2019, DOI 10.1155/2019/3560819
   Allahbadia Gautam N, 2008, Semin Reprod Med, V26, P22, DOI 10.1055/s-2007-992921
   Anand P, 2008, BIOCHEM PHARMACOL, V76, P1590, DOI 10.1016/j.bcp.2008.08.008
   [Anonymous], 2014, Int. J. Cell. Mol. Biotechnol, DOI [DOI 10.5899/2014/IJCMB-00014, 10.5899/2014/ijcmb-00014]
   [Anonymous], 2016, J ANIM RES, V29
   Asan SA, 2020, PROG NUTR, V22, DOI 10.23751/pn.v22i4.10460
   Baptiste CG, 2010, J STEROID BIOCHEM, V122, P42, DOI 10.1016/j.jsbmb.2009.12.010
   Baum L, 2007, PHARMACOL RES, V56, P509, DOI 10.1016/j.phrs.2007.09.013
   Bishop JL, 2011, COMPLEMENT THER MED, V19, P303, DOI 10.1016/j.ctim.2011.08.005
   Börchers S, 2017, N-S ARCH PHARMACOL, V390, P813, DOI 10.1007/s00210-017-1385-0
   Boudreaux Monique Y, 2006, Curr Diab Rep, V6, P77, DOI 10.1007/s11892-006-0056-1
   Cai LB, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0083402
   CASTELL JV, 1989, FEBS LETT, V242, P237, DOI 10.1016/0014-5793(89)80476-4
   Chen JT, 2010, J ALTERN COMPLEM MED, V16, P1295, DOI 10.1089/acm.2009.0696
   Chen SD, 2011, INT J MOL SCI, V12, P7199, DOI 10.3390/ijms12107199
   Chien YJ, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020684
   Daraï E, 2003, HUM REPROD, V18, P1681, DOI 10.1093/humrep/deg321
   Deligeoroglou E, 2012, GYNECOL ENDOCRINOL, V28, P974, DOI 10.3109/09513590.2012.683082
   Diamanti-Kandarakis E., 2009, Diagnosis management of polycystic ovary syndrome, P35, DOI [DOI 10.1007/978-0-387-09718-3_4, 10.1007/978-0-387-09718-3_4]
   Diamanti-Kandarakis E, 2006, ENDOCRINE, V30, P19, DOI 10.1385/ENDO:30:1:19
   Dokras A, 2005, OBSTET GYNECOL, V106, P131, DOI 10.1097/01.AOG.0000167408.30893.6b
   DRAPER HH, 1986, LIPIDS, V21, P305, DOI 10.1007/BF02536418
   Duleba AJ, 2012, FERTIL STERIL, V97, P7, DOI 10.1016/j.fertnstert.2011.11.023
   Ehrmann DA, 2005, NEW ENGL J MED, V352, P1223, DOI 10.1056/NEJMra041536
   Ejaz A, 2009, J NUTR, V139, P919, DOI 10.3945/jn.108.100966
   Emmanuel S., 2010, INT J PHARM BIOL SCI, V1, P15
   Esmaily H, 2015, CHIN J INTEGR MED, V21, P332, DOI 10.1007/s11655-015-2160-z
   Fauser BCJM, 2012, FERTIL STERIL, V97, P28, DOI 10.1016/j.fertnstert.2011.09.024
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Franks S, 2008, HUM REPROD UPDATE, V14, P367, DOI 10.1093/humupd/dmn015
   Fulghesu AM, 2011, MEDIAT INFLAMM, V2011, DOI 10.1155/2011/389317
   Ganie MA, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00699
   Gao LL, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0164021
   Ghaffarzad A, 2016, INT J FERTIL STERIL, V10, P29
   Ghelani H, 2019, BMC NEPHROL, V20, DOI 10.1186/s12882-019-1621-6
   Ghorbani Z, 2014, INT J ENDOCRINOL MET, V12, DOI 10.5812/ijem.18081
   HALLIWELL B, 1993, AM J CLIN NUTR, V57, P715
   Han KH, 2004, CIRCULATION, V109, P2566, DOI 10.1161/01.CIR.0000131160.94926.6E
   Hannan MA, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22169078
   Harada T, 2004, HUM REPROD UPDATE, V10, P29, DOI 10.1093/humupd/dmh007
   Harris Holly R, 2016, Fertil Res Pract, V2, P14, DOI 10.1186/s40738-016-0029-2
   Hasan ST, 2014, ATHEROSCLEROSIS, V232, P40, DOI 10.1016/j.atherosclerosis.2013.10.016
   Hedayat KM, 2019, THEORY OF ENDOBIOGENY, VOL 3: ADVANCED CONCEPTS FOR THE TREATMENT OF COMPLEX CLINICAL CONDITIONS, P69, DOI 10.1016/B978-0-12-816964-3.00004-3
   Henstridge DC, 2019, BRIT J PHARMACOL, V176, P4193, DOI 10.1111/bph.14642
   Heshmati J, 2021, PHYTOMEDICINE, V80, DOI 10.1016/j.phymed.2020.153395
   Heshmati J, 2020, DIAB MET SYND CLIN R, V14, P77, DOI 10.1016/j.dsx.2020.01.002
   Hewlings SJ, 2017, FOODS, V6, DOI 10.3390/foods6100092
   Hodaei H, 2019, DIABETOL METAB SYNDR, V11, DOI 10.1186/s13098-019-0437-7
   Hwang I, 2020, FREE RADICAL BIO MED, V148, P22, DOI 10.1016/j.freeradbiomed.2019.12.025
   Indira Pandiri Indira Pandiri, 2018, Journal of Advanced Biotechnology and Experimental Therapeutics, V1, P88
   Islam MN, 2021, PHYTOTHER RES, V35, P1329, DOI 10.1002/ptr.6895
   Jain Madhu, 2012, J Hum Reprod Sci, V5, P52, DOI 10.4103/0974-1208.97802
   Jamilian M, 2020, CLIN NUTR ESPEN, V36, P128, DOI 10.1016/j.clnesp.2020.01.005
   Jobin C, 1999, J IMMUNOL, V163, P3474
   Kadlec AO, 2016, ARTERIOSCL THROM VAS, V36, P1467, DOI 10.1161/ATVBAHA.116.307123
   Kalwat MA, 2013, EXP MOL MED, V45, DOI 10.1038/emm.2013.73
   Kamal DAM, 2021, NUTRIENTS, V13, DOI 10.3390/nu13093126
   Kang QH, 2009, BRIT J PHARMACOL, V157, P1354, DOI 10.1111/j.1476-5381.2009.00261.x
   Kato M, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600471
   Kim M, 2010, NUTR RES PRACT, V4, P191, DOI 10.4162/nrp.2010.4.3.191
   Kobayashi EH, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms11624
   Kumar A, 2005, CLIN ENDOCRINOL, V62, P644, DOI 10.1111/j.1365-2265.2005.02256.x
   Lao Christopher D, 2006, BMC Complement Altern Med, V6, P10, DOI 10.1186/1472-6882-6-10
   Lauritsen MP, 2014, HUM REPROD, V29, P791, DOI 10.1093/humrep/det469
   Laursen TL, 2019, WORLD J HEPATOL, V11, P138, DOI 10.4254/wjh.v11.i2.138
   Li GJ, 2014, EXP THER MED, V8, P1015, DOI 10.3892/etm.2014.1834
   Liu JJ, 2021, HUM REPROD, V36, P1108, DOI 10.1093/humrep/deaa371
   Lunny CA, 2010, J MIDWIFERY WOM HEAL, V55, P335, DOI 10.1016/j.jmwh.2009.10.015
   Malin SK, 2015, AM J PHYSIOL-ENDOC M, V308, pE770, DOI 10.1152/ajpendo.00510.2014
   Mao ZH, 2018, REPROD SCI, V25, P372, DOI 10.1177/1933719117715129
   Maradana MR, 2013, MOL NUTR FOOD RES, V57, P1550, DOI 10.1002/mnfr.201200791
   McAllister JM, 2015, TRENDS ENDOCRIN MET, V26, P118, DOI 10.1016/j.tem.2014.12.004
   McGrath KC, 2008, VASC HEALTH RISK MAN, V4, P11
   Mohammadi Shima, 2017, J Reprod Infertil, V18, P352
   Mohammadi S, 2017, CELL J, V19, P425, DOI 10.22074/cellj.2017.4415
   Mombaini E, 2017, PHYTOTHER RES, V31, P747, DOI 10.1002/ptr.5795
   Moni A., 2018, J ADV BIOTECHNOL EXP, V1, P7
   Nasser HA, 2019, J MED BIOCHEM, V38, P427, DOI 10.2478/jomb-2019-0012
   Nordeng Hedvig, 2011, Complement Ther Clin Pract, V17, P147, DOI 10.1016/j.ctcp.2010.09.002
   Okoroh EM, 2012, AM J OBSTET GYNECOL, V207, DOI 10.1016/j.ajog.2012.07.023
   Page MJ, 2021, BMJ-BRIT MED J, V372, DOI [10.1136/bmj.n71, 10.1136/bmj.n160]
   Pan YY, 2017, ROY SOC OPEN SCI, V4, DOI 10.1098/rsos.170917
   Panahi Y, 2018, J CELL PHYSIOL, V233, P141, DOI 10.1002/jcp.25756
   Parkash J, 2005, ANAT REC PART A, V286A, P982, DOI 10.1002/ar.a.20229
   Pergialiotis V, 2018, HORM MOL BIOL CLIN I, V34, DOI 10.1515/hmbci-2018-0002
   Pfluger PT, 2008, P NATL ACAD SCI USA, V105, P9793, DOI 10.1073/pnas.0802917105
   Rahimi HR, 2016, AVICENNA J PHYTOMEDI, V6, P383
   Raja MA, 2021, INT J NANOMED, V16, P6231, DOI 10.2147/IJN.S302161
   Raoofi A, 2018, J PHARM RES INT, V24, DOI 10.9734/JPRI/2018/45124
   Reddy P. S., 2016, Asian Pacific Journal of Reproduction, V5, P116
   Ridker PM, 2003, CIRCULATION, V107, P391, DOI 10.1161/01.CIR.0000055014.62083.05
   Rodin DA, 1998, CLIN ENDOCRINOL, V49, P91, DOI 10.1046/j.1365-2265.1998.00492.x
   Rojas Joselyn, 2014, Int J Reprod Med, V2014, P719050, DOI 10.1155/2014/719050
   Rosenfield RL, 2016, ENDOCR REV, V37, P467, DOI 10.1210/er.2015-1104
   Rui LY, 2001, J CLIN INVEST, V107, P181, DOI 10.1172/JCI10934
   Sanderson PA, 2017, HUM REPROD UPDATE, V23, P232, DOI 10.1093/humupd/dmw042
   Shahmoradi MK, 2018, GMJ Med, V2, P80, DOI [DOI 10.29088/GMJM.2018.80, 10.29088/GMJM.2018.80]
   Sharma RA, 2004, CLIN CANCER RES, V10, P6847, DOI 10.1158/1078-0432.CCR-04-0744
   Shen Z, 2009, AM J PHYSIOL-GASTR L, V296, pG1047, DOI 10.1152/ajpgi.00016.2009
   Simental-Mendía LE, 2022, REPROD SCI, V29, P3124, DOI 10.1007/s43032-021-00761-6
   Sirmans SM, 2014, CLIN EPIDEMIOL, V6, P1, DOI 10.2147/CLEP.S37559
   Smith CA, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-224
   Sohaei S, 2019, COMPLEMENT THER MED, V47, DOI 10.1016/j.ctim.2019.102201
   Sohrevardi SM, 2021, ADV EXP MED BIOL, V1308, P109, DOI 10.1007/978-3-030-64872-5_9
   Solorzano CMB, 2012, STEROIDS, V77, P332, DOI 10.1016/j.steroids.2011.12.007
   Stankiewicz M, 2007, AUST NZ J OBSTET GYN, V47, P145, DOI 10.1111/j.1479-828X.2007.00702.x
   Strauss JF, 2003, ANN NY ACAD SCI, V997, P42, DOI 10.1196/annals.1290.005
   Suryanarayana P, 2007, MED SCI MONITOR, V13, pBR286
   Tapia E, 2016, FREE RADICAL RES, V50, P781, DOI 10.1080/10715762.2016.1174776
   Teede HJ, 2011, MED J AUSTRALIA, V195, pS69, DOI 10.5694/mja11.10915
   Thota RN, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-32032-x
   Uddin MJ, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10020258
   Walters KA, 2018, TRENDS ENDOCRIN MET, V29, P842, DOI 10.1016/j.tem.2018.08.005
   Wang XN, 2017, CHINESE MED J-PEKING, V130, P1026, DOI 10.4103/0366-6999.204927
   Wang YJ, 1997, J PHARMACEUT BIOMED, V15, P1867, DOI 10.1016/S0731-7085(96)02024-9
   Witchel SF, 2019, J ENDOCR SOC, V3, P1545, DOI 10.1210/js.2019-00078
   Wojcik M, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/9698258
   Wu XK, 2016, FERTIL STERIL, V106, P757, DOI 10.1016/j.fertnstert.2016.05.022
   Wu XK, 2003, FERTIL STERIL, V80, P954, DOI 10.1016/S0015-0282(03)01007-0
   Xia ZH, 2020, MOLECULES, V25, DOI 10.3390/molecules25020271
   Yang YS, 2014, PHYTOTHER RES, V28, P1770, DOI 10.1002/ptr.5197
   YEN SSC, 1980, CLIN ENDOCRINOL, V12, P177, DOI 10.1111/j.1365-2265.1980.tb02132.x
   Yildiz BO, 2007, REV ENDOCR METAB DIS, V8, P331, DOI 10.1007/s11154-007-9054-0
   Zhang CK, 2018, INT J ONCOL, V53, P2531, DOI 10.3892/ijo.2018.4569
   Zuo T, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/8589318
NR 135
TC 11
Z9 12
U1 4
U2 17
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD JUN
PY 2023
VL 9
IS 6
AR e16957
DI 10.1016/j.heliyon.2023.e16957
EA JUN 2023
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA O1FJ1
UT WOS:001041343000001
PM 37346347
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ruiz, GP
   Camara, H
   Fazolini, NPB
   Mori, MA
AF Ruiz, Gabriel Palermo
   Camara, Henrique
   Fazolini, Narayana P. B.
   Mori, Marcelo A.
TI Extracellular miRNAs in redox signaling: Health, disease and potential
   therapies
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Oxidative stress; Redox biology; miRNA; Extracellular vesicles;
   Exosomes; Cancer; Cardiovascular disease; Metabolic syndrome;
   Neurodegenerative diseases; Aging; RNA therapeutics
ID SMOOTH-MUSCLE-CELLS; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; BETA-CELL; CIRCULATING MICROPARTICLES; CARDIOMYOCYTE
   APOPTOSIS; MACROPHAGE ACTIVATION; MICRORNA BIOGENESIS; ENDOTHELIAL-CELLS
AB Extracellular microRNAs (miRNAs) have emerged as important mediators of cell-to-cell communication and intertissue crosstalk. MiRNAs are produced by virtually all types of eukaryotic cells and can be selectively packaged and released to the extracellular medium, where they may reach distal cells to regulate gene expression cell non-autonomously. By doing so, miRNAs participate in integrative physiology. Oxidative stress affects miRNA expression, while miRNAs control redox signaling. Disruption in miRNA expression, processing or release to the extracellular compartment are associated with aging and a number of chronic diseases, such as obesity, type 2 diabetes, neurodegenerative diseases and cancer, all of them being conditions related to oxidative stress. Here we discuss the interplay between redox balance and miRNA function and secretion as a determinant of health and disease states, reviewing the findings that support this notion and highlighting novel and yet understudied venues of research in the field.
C1 [Ruiz, Gabriel Palermo; Camara, Henrique; Fazolini, Narayana P. B.; Mori, Marcelo A.] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Campinas, SP, Brazil.
   [Mori, Marcelo A.] Univ Estadual Campinas, Expt Med Res Cluster EMRC, Campinas, SP, Brazil.
   [Mori, Marcelo A.] Univ Estadual Campinas, Obes & Comorbid Res Ctr OCRC, Campinas, SP, Brazil.
C3 Universidade Estadual de Campinas; Universidade de Sao Paulo;
   Universidade Estadual de Campinas; Universidade Estadual de Campinas
RP Mori, MA (corresponding author), Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Campinas, SP, Brazil.
EM morima@unicamp.br
RI Camara, Henrique/KDO-6799-2024; Mori, Marcelo/R-2881-2018
OI Camara, Henrique/0000-0001-7300-1416; Palermo Ruiz,
   Gabriel/0000-0002-5660-1396
FU Fundacao de Amparo a` Pesquisa do Estado de Sao Paulo [2017/01339-2,
   2018/21635-8, 2017/01184-9, 2017/07975-8, 2017/23920-9]; Fundacao de
   Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [17/23920-9,
   17/01339-2, 18/21635-8, 17/01184-9] Funding Source: FAPESP
FX We acknowledge Fabio Hecht for the illustrations and artwork. Au-thors
   were supported by grants of Fundacao de Amparo a` Pesquisa do Estado de
   Sao Paulo (2017/01339-2 to H.C.; 2018/21635-8 to G.P.R.; and
   2017/01184-9, 2017/07975-8, and 2017/23920-9 to M.A.M) .
CR Amabile N, 2014, EUR HEART J, V35, P2972, DOI 10.1093/eurheartj/ehu153
   [Anonymous], 2019, J ENDOCR SOC, DOI DOI 10.1210/JS.2019-OR01-3
   AO BBB, 2020, P NATL ACAD SCI USA, V117, P23932
   Armand-Labit Virginie, 2017, BioMolecular Concepts, V8, P61, DOI 10.1515/bmc-2017-0002
   Arroyo JD, 2011, P NATL ACAD SCI USA, V108, P5003, DOI 10.1073/pnas.1019055108
   Asano N, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-09143-8
   Bai XY, 2011, J AM SOC NEPHROL, V22, P1252, DOI 10.1681/ASN.2010040367
   Baker JR, 2016, SCI REP-UK, V6, DOI 10.1038/srep35871
   Bang C, 2014, J CLIN INVEST, V124, P2136, DOI 10.1172/JCI70577
   Barile L, 2014, CARDIOVASC RES, V103, P530, DOI 10.1093/cvr/cvu167
   Bartel DP, 2018, CELL, V173, P20, DOI 10.1016/j.cell.2018.03.006
   Bartel DP, 2009, CELL, V136, P215, DOI 10.1016/j.cell.2009.01.002
   Berra E, 2003, EMBO J, V22, P4082, DOI 10.1093/emboj/cdg392
   Bobrie A, 2012, J EXTRACELL VESICLES, V1, DOI 10.3402/jev.v1i0.18397
   Bosisio D, 2019, CANCER LETT, V452, P59, DOI 10.1016/j.canlet.2019.03.021
   Brancucci N. M. B., 2017, CELL, V171, P1532, DOI [DOI 10.1016/J.CELL.2017, 10.1016/j.cell.2017.10.020, DOI 10.1016/J.CELL.2017.10.020]
   Burbulla LF, 2017, SCIENCE, V357, P1255, DOI 10.1126/science.aam9080
   Campello E, 2016, INTERN EMERG MED, V11, P695, DOI 10.1007/s11739-016-1397-7
   Cao W. -H, 2017, EUR REV MED PHARMACO, DOI [10.26355/eurrev_201708_13273, DOI 10.26355/EURREV_201708_13273]
   Carbonell T, 2020, REDOX BIOL, V36, DOI 10.1016/j.redox.2020.101607
   Carlomosti F, 2017, ANTIOXID REDOX SIGN, V27, P328, DOI 10.1089/ars.2016.6643
   Casadei L, 2017, CANCER RES, V77, P3846, DOI 10.1158/0008-5472.CAN-16-2984
   Castaño C, 2018, P NATL ACAD SCI USA, V115, P12158, DOI 10.1073/pnas.1808855115
   Chandrasekaran A, 2017, REDOX BIOL, V11, P91, DOI 10.1016/j.redox.2016.11.005
   Chao JL, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/5025610
   Chartoumpekis DV, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034872
   Checa J, 2020, J INFLAMM RES, V13, P1057, DOI 10.2147/JIR.S275595
   Chen C, 2015, J CELL MOL MED, V19, P970, DOI 10.1111/jcmm.12483
   Chen CYA, 2011, WIRES RNA, V2, P167, DOI 10.1002/wrna.40
   Chen JF, 2008, P NATL ACAD SCI USA, V105, P2111, DOI 10.1073/pnas.0710228105
   Chen Z, 2010, ONCOGENE, V29, P4362, DOI 10.1038/onc.2010.193
   Cheng ZY, 2013, ANTIOXID REDOX SIGN, V19, P240, DOI 10.1089/ars.2013.5255
   Chevillet JR, 2014, P NATL ACAD SCI USA, V111, P14888, DOI 10.1073/pnas.1408301111
   Chibaya L, 2021, P NATL ACAD SCI USA, V118, DOI 10.1073/pnas.2003193118
   Chim SSC, 2008, CLIN CHEM, V54, P482, DOI 10.1373/clinchem.2007.097972
   Chuang T.-Y., 2015, J DIABETES RES J DIA, V2015, pe943659, DOI [DOI 10.1155/2015/943659, 10.1155/2015/943659]
   Collin F, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20102407
   Cvjetkovic A, 2014, J EXTRACELL VESICLES, V3, DOI 10.3402/jev.v3.23111
   Das S, 2019, CELL, V177, P231, DOI 10.1016/j.cell.2019.03.023
   DAVIS C, 2017, TISSUE ENG
   de Couto G, 2017, CIRCULATION, V136, P200, DOI 10.1161/CIRCULATIONAHA.116.024590
   Pérez DD, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-60212-1
   Deiuliis JA, 2016, INT J OBESITY, V40, P88, DOI 10.1038/ijo.2015.170
   Deline B, 2018, P NATL ACAD SCI USA, V115, pE8909, DOI 10.1073/pnas.1810575115
   Dimmeler S, 2013, EMBO MOL MED, V5, P180, DOI 10.1002/emmm.201201986
   Dohm JC, 2008, NUCLEIC ACIDS RES, V36, DOI 10.1093/nar/gkn425
   Dong YH, 2019, INT J BIOL SCI, V15, P680, DOI 10.7150/ijbs.30464
   Eacker SM, 2013, FRONT CELL NEUROSCI, V7, DOI 10.3389/fncel.2013.00136
   Esau C, 2006, CELL METAB, V3, P87, DOI 10.1016/j.cmet.2006.01.005
   Espinosa-Diez C, 2015, REDOX BIOL, V6, P183, DOI 10.1016/j.redox.2015.07.008
   Espinosa-Diez C, 2015, ANTIOXID REDOX SIGN, V23, P1092, DOI 10.1089/ars.2014.6025
   Feng YL, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0088685
   Fierro-Fernández M, 2016, REDOX BIOL, V7, P58, DOI 10.1016/j.redox.2015.11.006
   Flaherty SE, 2019, SCIENCE, V363, P989, DOI 10.1126/science.aaw2586
   Franceschi C, 2014, J GERONTOL A-BIOL, V69, pS4, DOI 10.1093/gerona/glu057
   Frost RJA, 2011, P NATL ACAD SCI USA, V108, P21075, DOI 10.1073/pnas.1118922109
   Fujisaka S, 2013, DIABETOLOGIA, V56, P1403, DOI 10.1007/s00125-013-2885-1
   Fulzele S, 2019, AGING-US, V11, P1791, DOI 10.18632/aging.101874
   Gayen M, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21072312
   Gibbings DJ, 2009, NAT CELL BIOL, V11, P1143, DOI 10.1038/ncb1929
   Gmerek L, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0222013
   Goren Y, 2012, EUR J HEART FAIL, V14, P147, DOI 10.1093/eurjhf/hfr155
   Grueter CE, 2012, CELL, V149, P671, DOI 10.1016/j.cell.2012.03.029
   Haneklaus M, 2012, J IMMUNOL, V189, P3795, DOI 10.4049/jimmunol.1200312
   Hansen KD, 2010, NUCLEIC ACIDS RES, V38, DOI 10.1093/nar/gkq224
   He S, 2018, SCAND J IMMUNOL, V87, DOI 10.1111/sji.12648
   Heimberg AM, 2008, P NATL ACAD SCI USA, V105, P2946, DOI 10.1073/pnas.0712259105
   Heman-Ackah SM, 2013, FRONT MOL NEUROSCI, V6, DOI 10.3389/fnmol.2013.00040
   Hergenreider E, 2012, NAT CELL BIOL, V14, P249, DOI 10.1038/ncb2441
   Ibrahim AGE, 2014, STEM CELL REP, V2, P606, DOI 10.1016/j.stemcr.2014.04.006
   Iwasaki S, 2010, MOL CELL, V39, P292, DOI 10.1016/j.molcel.2010.05.015
   Jackstadt R, 2015, BBA-GENE REGUL MECH, V1849, P544, DOI 10.1016/j.bbagrm.2014.04.003
   Jaeger A, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-32274-9
   Jansen F, 2017, CIRC RES, V120, P1649, DOI 10.1161/CIRCRESAHA.117.310752
   Jansen F, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.114.001249
   Jeppesen DK, 2019, CELL, V177, P428, DOI 10.1016/j.cell.2019.02.029
   Jeppesen DK, 2014, J EXTRACELL VESICLES, V3, DOI 10.3402/jev.v3.25011
   Jiang Y, 2014, SCI REP-UK, V4, DOI 10.1038/srep05026
   JIN Y, 2019, SCI REP-UK
   Jonas S, 2015, NAT REV GENET, V16, P421, DOI 10.1038/nrg3965
   Jones A, 2017, OBESITY, V25, P1734, DOI 10.1002/oby.21950
   Kalinina EV, 2019, BIOCHEMISTRY-MOSCOW+, V84, P1233, DOI 10.1134/S0006297919110026
   Kamenska A, 2016, NUCLEIC ACIDS RES, V44, P6318, DOI 10.1093/nar/gkw565
   Kamenska A, 2014, NUCLEIC ACIDS RES, V42, P3298, DOI 10.1093/nar/gkt1265
   Kang T, 2016, STEM CELL TRANSL MED, V5, P440, DOI 10.5966/sctm.2015-0177
   Kanthasamy A.G., 2018, NEUROTOXICOLOGY
   Kawamata T, 2010, TRENDS BIOCHEM SCI, V35, P368, DOI 10.1016/j.tibs.2010.03.009
   Kawase-Koga Y, 2009, DEV DYNAM, V238, P2800, DOI 10.1002/dvdy.22109
   Kern JC, 2005, FRONT BIOSCI-LANDMRK, V10, P1727, DOI 10.2741/1656
   Kim HJ, 2014, DIABETES, V63, P4045, DOI 10.2337/db14-0466
   Koppers-Lalic D, 2014, CELL REP, V8, P1649, DOI 10.1016/j.celrep.2014.08.027
   Kosaka N, 2010, J BIOL CHEM, V285, P17442, DOI 10.1074/jbc.M110.107821
   Krol J, 2010, NAT REV GENET, V11, P597, DOI 10.1038/nrg2843
   Krützfeldt J, 2005, NATURE, V438, P685, DOI 10.1038/nature04303
   KUMAR A, 2016, J HUNTINGTONS DIS, DOI DOI 10.3233/JHD
   Kurowska-Stolarska M, 2011, P NATL ACAD SCI USA, V108, P11193, DOI 10.1073/pnas.1019536108
   Lambeth JD, 2004, NAT REV IMMUNOL, V4, P181, DOI 10.1038/nri1312
   Lan JQ, 2019, CANCER RES, V79, P146, DOI 10.1158/0008-5472.CAN-18-0014
   Lang A, 2016, AGING-US, V8, P484, DOI 10.18632/aging.100905
   Lawrie CH, 2008, BRIT J HAEMATOL, V141, P672, DOI 10.1111/j.1365-2141.2008.07077.x
   Lee H, 2019, J EXP MED, V216, P2202, DOI 10.1084/jem.20182313
   Lee Y, 2003, NATURE, V425, P415, DOI 10.1038/nature01957
   Leisegang MS, 2018, ANTIOXID REDOX SIGN, V29, P793, DOI 10.1089/ars.2017.7276
   LeMaster E, 2017, FASEB J, V31
   Lewis BP, 2005, CELL, V120, P15, DOI 10.1016/j.cell.2004.12.035
   Li N, 2017, NEUROL SCI, V38, P761, DOI 10.1007/s10072-017-2841-9
   Li R, 2013, KIDNEY INT, V84, P1129, DOI 10.1038/ki.2013.272
   Li SY, 2016, CELL PHYSIOL BIOCHEM, V39, P2439, DOI 10.1159/000452512
   Li T, 2020, CIRC J, V84, P1304, DOI 10.1253/circj.CJ-19-1060
   Li XL, 2014, GENE, V533, P1, DOI 10.1016/j.gene.2013.09.105
   Liang YZ, 2020, J DIABETES, V12, P633, DOI 10.1111/1753-0407.12643
   Lim LP, 2005, NATURE, V433, P769, DOI 10.1038/nature03315
   Lin XL, 2016, PLOS GENET, V12, DOI 10.1371/journal.pgen.1006308
   Lin YH, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20184497
   Linhares-Lacerda L, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-59486-2
   Liu H, 2017, EUR REV MED PHARMACO, V21, P2734
   Long B, 2017, MOL CELLS, V40, P542, DOI 10.14348/molcells.2017.0012
   Lopez YON, 2017, MOL BIOSYST, V13, P106, DOI 10.1039/c6mb00596a
   Lu H, 2010, CARDIOVASC RES, V86, P410, DOI 10.1093/cvr/cvq010
   Lu P, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0185992
   Lynn FC, 2007, DIABETES, V56, P2938, DOI 10.2337/db07-0175
   Magenta A, 2011, CELL DEATH DIFFER, V18, P1628, DOI 10.1038/cdd.2011.42
   Makarova J, 2021, TRENDS BIOCHEM SCI, V46, P640, DOI 10.1016/j.tibs.2021.01.007
   Malag on, 2021, MOL THER-NUCL ACIDS
   Marchand L., 2015, J MOL BIOMARKERS DIA, DOI [10.4172/2155-9929.1000251,06, DOI 10.4172/2155-9929.1000251,06]
   Marengo B, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-32195-7
   Mateescu B, 2017, J EXTRACELL VESICLES, V6, DOI 10.1080/20013078.2017.1286095
   Mayo JS, 2019, PRS-GLOB OPEN, V7, DOI 10.1097/GOX.0000000000002588
   McKenzie AJ, 2016, CELL REP, V15, P978, DOI 10.1016/j.celrep.2016.03.085
   Melo SA, 2014, CANCER CELL, V26, P707, DOI 10.1016/j.ccell.2014.09.005
   Milosavljevic A, 2020, CELL REP
   Mittelbrunn M, 2011, NAT COMMUN, V2, DOI 10.1038/ncomms1285
   Mittler R, 2011, TRENDS PLANT SCI, V16, P300, DOI 10.1016/j.tplants.2011.03.007
   Montecalvo A, 2012, BLOOD, V119, P756, DOI 10.1182/blood-2011-02-338004
   Mori MA, 2019, CELL METAB, V30, P656, DOI 10.1016/j.cmet.2019.07.011
   Mori MA, 2014, J CLIN INVEST, V124, P3339, DOI 10.1172/JCI73468
   Mori MA, 2012, CELL METAB, V16, P336, DOI 10.1016/j.cmet.2012.07.017
   Müller G, 2011, CELL SIGNAL, V23, P1207, DOI 10.1016/j.cellsig.2011.03.013
   Munir J, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9102271
   Murillo OD, 2019, CELL, V177, P463, DOI 10.1016/j.cell.2019.02.018
   Niedzielska E, 2016, MOL NEUROBIOL, V53, P4094, DOI 10.1007/s12035-015-9337-5
   Nishimura T, 2015, CELL REP, V11, P1425, DOI 10.1016/j.celrep.2015.04.065
   Nunomura A, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/2638130
   O'Rourke JR, 2007, DEV BIOL, V311, P359, DOI 10.1016/j.ydbio.2007.08.032
   Ohno S, 2013, MOL THER, V21, P185, DOI 10.1038/mt.2012.180
   Oltra M, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-54373-x
   Ong SG, 2014, CIRCULATION, V130, pS60, DOI 10.1161/CIRCULATIONAHA.113.007917
   Ono K, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0191553
   Ortega FJ, 2014, DIABETES CARE, V37, P1375, DOI 10.2337/dc13-1847
   Ortiz-Dosal A, 2019, BIOMARKERS, V24, P499, DOI 10.1080/1354750X.2019.1606279
   Ovadya Y, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-07825-3
   Ozgur S, 2015, CELL REP, V13, P703, DOI 10.1016/j.celrep.2015.09.033
   Papaconstantinou J, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8111383
   Patel GK, 2017, BRIT J CANCER, V116, P609, DOI 10.1038/bjc.2017.18
   Peng Y, 2016, SIGNAL TRANSDUCT TAR, V1, DOI 10.1038/sigtrans.2015.4
   Phinney DG, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms9472
   Pinto S, 2017, FRONT NEUROSCI-SWITZ, V11, DOI 10.3389/fnins.2017.00273
   Pinto S, 2018, REDOX BIOL, V18, P84, DOI 10.1016/j.redox.2018.06.006
   Pirola CJ, 2015, GUT, V64, P800, DOI 10.1136/gutjnl-2014-306996
   Poy MN, 2009, P NATL ACAD SCI USA, V106, P5813, DOI 10.1073/pnas.0810550106
   Poy MN, 2004, NATURE, V432, P226, DOI 10.1038/nature03076
   Rao KVR, 2004, J BIOL CHEM, V279, P32333, DOI 10.1074/jbc.M402096200
   Reis FCG, 2016, AGING-US, V8, P1201, DOI 10.18632/aging.100970
   Ribeiro-Rodrigues TM, 2017, CARDIOVASC RES, V113, P1338, DOI 10.1093/cvr/cvx118
   Rocha AL, 2020, SCI ADV, V6, DOI 10.1126/sciadv.abc6250
   Rosen ED, 2014, CELL, V156, P20, DOI 10.1016/j.cell.2013.12.012
   Santangelo A, 2018, J NEURO-ONCOL, V136, P51, DOI 10.1007/s11060-017-2639-x
   Santangelo L, 2016, CELL REP, V17, P799, DOI 10.1016/j.celrep.2016.09.031
   Schafer F.Q., 2003, Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles, P1, DOI DOI 10.1007/0-306-48412-9_1
   Schulte C, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0145930
   Sekine S, 2009, GASTROENTEROLOGY, V136, P2304, DOI 10.1053/j.gastro.2009.02.067
   SERAFIN A, 2015, NEUROLOGY
   Shan Z, 2015, J AM COLL CARDIOL, V65, P2526, DOI 10.1016/j.jacc.2015.03.570
   Shi ZH, 2014, ENDOCRINOLOGY, V155, P1982, DOI 10.1210/en.2013-2046
   Shurtleff MJ, 2018, ANNU REV CANC BIOL, V2, P395, DOI 10.1146/annurev-cancerbio-030617-050519
   Shurtleff MJ, 2016, ELIFE, V5, DOI 10.7554/eLife.19276
   Sohn W, 2015, EXP MOL MED, V47, DOI 10.1038/emm.2015.68
   Squadrito ML, 2014, CELL REP, V8, P1432, DOI 10.1016/j.celrep.2014.07.035
   Srinivasan S, 2019, CELL, V177, P446, DOI 10.1016/j.cell.2019.03.024
   Stepanian A, 2013, OBESITY, V21, P2236, DOI 10.1002/oby.20365
   Su J, 2020, CHEM SCI, V11, P80, DOI 10.1039/c9sc04823e
   Sun Y, 2015, FRONT CELL NEUROSCI, V9, DOI 10.3389/fncel.2015.00193
   Temoche-Diaz MM, 2019, ELIFE, V8, DOI 10.7554/eLife.47544
   Teng Y, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms14448
   TERLECKIZANIEWI.L, 2018, AGING CLIN EXP RES
   Théry C, 2018, J EXTRACELL VESICLES, V7, DOI 10.1080/20013078.2018.1535750
   Tho LC, 2016, THERANOSTICS, V6, P2068, DOI 10.7150/thno.15007
   Thomou T, 2017, NATURE, V542, P450, DOI 10.1038/nature21365
   Tian CH, 2020, J MOL CELL CARDIOL, V143, P120, DOI 10.1016/j.yjmcc.2020.04.032
   Tian CH, 2018, AM J PHYSIOL-HEART C, V314, pH928, DOI 10.1152/ajpheart.00602.2017
   Trajkovic K, 2008, SCIENCE, V319, P1244, DOI 10.1126/science.1153124
   Tsukamoto H, 2020, ISCIENCE, V23, DOI 10.1016/j.isci.2020.101520
   Turchinovich A., 2013, Frontiers in Genetics, V4, P119, DOI 10.3389/fgene.2013.00119
   Turchinoyich A, 2016, TRENDS BIOCHEM SCI, V41, P883, DOI 10.1016/j.tibs.2016.08.004
   Umezu T, 2014, BLOOD, V124, P3748, DOI 10.1182/blood-2014-05-576116
   Valadi H, 2007, NAT CELL BIOL, V9, P654, DOI 10.1038/ncb1596
   Van Deun J, 2017, NAT METHODS, V14, P228, DOI 10.1038/nmeth.4185
   Vickers KC, 2014, P NATL ACAD SCI USA, V111, P14518, DOI 10.1073/pnas.1215767111
   Vickers KC, 2011, NAT CELL BIOL, V13, P423, DOI 10.1038/ncb2210
   Villarroya-Beltri C, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3980
   Vishnoi A, 2017, METHODS MOL BIOL, V1509, P1, DOI 10.1007/978-1-4939-6524-3_1
   Walenta K, 2012, EUR HEART J, V33, P1469, DOI 10.1093/eurheartj/ehr485
   Wan Y, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/5189138
   Wang JX, 2015, MOL CELL, V59, P50, DOI 10.1016/j.molcel.2015.05.003
   Wang K, 2010, NUCLEIC ACIDS RES, V38, DOI 10.1093/nar/gkq603
   Wang L, 2020, J NANOBIOTECHNOL, V18, DOI 10.1186/s12951-020-00711-5
   Wang L, 2015, CELL STRESS CHAPERON, V20, P411, DOI 10.1007/s12192-014-0565-9
   Wang R, 2015, EUR J ENDOCRINOL, V172, P291, DOI 10.1530/EJE-14-0867
   Wang XH, 2009, CLIN EXP PHARMACOL P, V36, P181, DOI 10.1111/j.1440-1681.2008.05057.x
   Wang XH, 2014, J MOL CELL CARDIOL, V74, P139, DOI 10.1016/j.yjmcc.2014.05.001
   Wang Y, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/4971261
   Wang YC, 2013, DIABETOLOGIA, V56, P2275, DOI 10.1007/s00125-013-2996-8
   Weaver AM, 2020, CANCER RES, V80, P379, DOI 10.1158/0008-5472.CAN-19-2782
   Weber JA, 2010, CLIN CHEM, V56, P1733, DOI 10.1373/clinchem.2010.147405
   Wen DZ, 2015, OBES RES CLIN PRACT, V9, P398, DOI 10.1016/j.orcp.2015.01.006
   Wendt S, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-33862-5
   Wiklander OPB, 2019, SCI TRANSL MED, V11, DOI 10.1126/scitranslmed.aav8521
   WILLEIT P, 2017, DIABETES
   Willems PHGM, 2015, CELL METAB, V22, P207, DOI 10.1016/j.cmet.2015.06.006
   Williams Z, 2013, P NATL ACAD SCI USA, V110, P4255, DOI 10.1073/pnas.1214046110
   Wilson RC, 2015, MOL CELL, V57, P397, DOI 10.1016/j.molcel.2014.11.030
   Wlodarski A, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21186902
   Xiao J, 2016, CELL DEATH DIS, V7, DOI 10.1038/cddis.2016.181
   Xiao YT, 2015, CELL CYCLE, V14, P1548, DOI 10.1080/15384101.2015.1026491
   Xie HM, 2009, DIABETES, V58, P1050, DOI 10.2337/db08-1299
   Xiong Y, 2020, J NANOBIOTECHNOL, V18, DOI 10.1186/s12951-020-00622-5
   Xu HX, 2020, PLOS BIOL, V18, DOI 10.1371/journal.pbio.3000603
   Xue G, 2015, ONCOGENE, V34, P1393, DOI 10.1038/onc.2014.82
   Yao F, 2017, EXP CELL RES, V355, P105, DOI 10.1016/j.yexcr.2017.03.060
   Yeung CLA, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms11150
   Ying W, 2019, CELL METAB, V29, P457, DOI 10.1016/j.cmet.2018.12.003
   Yu AM, 2019, PHARMACOL THERAPEUT, V196, P91, DOI 10.1016/j.pharmthera.2018.11.011
   Yu T, 2019, BRAZ J MED BIOL RES, V52, DOI [10.1590/1414-431X20198735, 10.1590/1414-431x20198735]
   Yu Y, 2018, THERANOSTICS, V8, P2171, DOI 10.7150/thno.22565
   Yuan XG, 2020, COMMUN BIOL, V3, DOI 10.1038/s42003-020-01514-y
   Zampetaki A, 2010, CIRC RES, V107, P810, DOI 10.1161/CIRCRESAHA.110.226357
   Zeh N, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0221679
   Zeiher, 2017, SCI REP-UK, V7, P1
   Zhang AM, 2018, BIOCHEM BIOPH RES CO, V495, P1648, DOI 10.1016/j.bbrc.2017.12.028
   Zhang D, 2019, THORAX, V74, P865, DOI 10.1136/thoraxjnl-2018-212994
   Zhang Q, 2019, CELL REP, V27, P940, DOI 10.1016/j.celrep.2019.01.009
   Zhang XM, 2012, CANCER RES, V72, P4707, DOI 10.1158/0008-5472.CAN-12-0639
   Zhang YL, 2017, NATURE, V548, P52, DOI 10.1038/nature23282
   Zhang YQ, 2016, J MOL CELL BIOL, V8, P505, DOI 10.1093/jmcb/mjw040
   Zhang YY, 2013, INT J MOL MED, V31, P797, DOI 10.3892/ijmm.2013.1260
   Zhang YG, 2019, CELL CYCLE, V18, P2674, DOI 10.1080/15384101.2019.1654797
   Zhao HL, 2010, PANCREAS, V39, P843, DOI 10.1097/MPA.0b013e3181d12613
   Zhao Y, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-14450-6
   Zheng W, 2011, BMC BIOINFORMATICS, V12, DOI 10.1186/1471-2105-12-290
   Zhou L, 2020, GUT
   Zhu HQ, 2011, CARDIOVASC RES, V92, P75, DOI 10.1093/cvr/cvr145
   Zhu XH, 2017, J EXTRACELL VESICLES, V6, DOI 10.1080/20013078.2017.1324730
   Zhuang GQ, 2012, CIRCULATION, V125, P2892, DOI 10.1161/CIRCULATIONAHA.111.087817
   Zietzer A, 2020, J EXTRACELL VESICLES, V9, DOI 10.1080/20013078.2020.1786967
   Zou JF, 2020, EUR REV MED PHARMACO, V24, P11251, DOI 10.26355/eurrev_202011_23614
NR 255
TC 19
Z9 20
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD SEP
PY 2021
VL 173
BP 170
EP 187
DI 10.1016/j.freeradbiomed.2021.05.004
EA JUL 2021
PG 18
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA UJ8NA
UT WOS:000691534600002
PM 33965563
DA 2025-06-11
ER

PT J
AU Yubero-Serrano, EM
   Lopez-Moreno, J
   Gomez-Delgado, F
   Lopez-Miranda, J
AF Yubero-Serrano, Elena M.
   Lopez-Moreno, Javier
   Gomez-Delgado, Francisco
   Lopez-Miranda, Jose
TI Extra virgin olive oil: More than a healthy fat
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article; Proceedings Paper
CT 11th International Mediterranean Diet Conference on Mediterranean Diet
   as a Lifestyle and Dynamic Food Pattern
CY APR, 2016
CL Barcelona, SPAIN
ID CARDIOVASCULAR RISK-FACTORS; POSTPRANDIAL ENDOTHELIAL FUNCTION;
   MEDITERRANEAN-STYLE DIET; LOW-DENSITY-LIPOPROTEIN;
   CORONARY-HEART-DISEASE; METABOLIC SYNDROME; PHENOLIC-COMPOUNDS;
   OXIDATIVE STRESS; ELDERLY-MEN; FACTOR-VII
AB The beneficial effects of a Mediterranean diet on human health and, in particular, on lowering risk of cardiovascular disease, has been mainly attributed to its high content to extra virgin olive oil (EVOO). While its main fatty acid, oleic acid, is considered important to these effects, EVOO has other biological properties that depend on, or are potentiated by other minor components of this oil. Initially, the mechanisms considered as possible causes of this cardioprotective effect of EVOO were based on the incidence on the so-called traditional risk factors (especially lipids and blood pressure). However, the high relative reduction in the prevalence of cardiovascular morbidity and mortality were not proportional to the limited findings about regulation of those traditional risk factors. In addition to several studies confirming the above effects, current research on beneficial effect of EVOO, and in particular in conjunction with Mediterranean style diets, is being focused on defining its effects on newer cardiovascular risk factors, such as inflammation, oxidative stress, coagulation, platelet aggregation, fibrinolysis, endothelial function or lipids or on the modulation of the conditions which predispose people to cardiovascular events, such as obesity, metabolic syndrome or type 2 diabetes mellitus. In the current review, we will mainly focus on reviewing the current evidence about the effects that EVOO exerts on alternative factors, including postprandial lipemia or coagulation, among others, discussing the underlying mechanism by which it exerts its effect, as well as providing a short review on future directions.
C1 [Yubero-Serrano, Elena M.; Lopez-Moreno, Javier; Gomez-Delgado, Francisco; Lopez-Miranda, Jose] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Lipids & Atherosclerosis Unit, Cordoba, Spain.
   [Yubero-Serrano, Elena M.; Lopez-Moreno, Javier; Gomez-Delgado, Francisco; Lopez-Miranda, Jose] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
C3 Universidad de Cordoba; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN
RP Lopez-Miranda, J (corresponding author), Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Lipids & Atherosclerosis Unit, Cordoba, Spain.; Lopez-Miranda, J (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
EM jlopezmir@uco.es
RI YUBERO, ELENA/AFM-2738-2022; Lopez-Miranda, Jose/Y-8306-2019; Gomez
   Delgado, Francisco/H-4552-2015
OI Lopez-Miranda, Jose/0000-0002-8844-0718; Yubero-Serrano, Elena
   M/0000-0002-2733-5359; Gomez Delgado, Francisco/0000-0002-0216-2084
FU Ministry of Science and Innovation [AGL2004-07907, AGL2006-01979,
   AGL2009-12270]; Ministry of Science and Competitiveness [AGL2012-39615,
   AGL2015-67896-P]; Carlos III Health Institute (FIS) [PIE14/00031,
   PIE14/00005]; Ministry of Economy, Innovation, Science and Employment
   [CVI-7450]; Mediterranean Diet Foundation; Diputacio de Barcelona
FX Supported in part by research grants from the Ministry of Science and
   Innovation (AGL2004-07907, AGL2006-01979, AGL2009-12270), Ministry of
   Science and Competitiveness (AGL2012-39615, AGL2015-67896-P), Training
   in health research Proyects by Carlos III Health Institute (FIS)
   (PIE14/00031 and PIE14/00005), Ministry of Economy, Innovation, Science
   and Employment (CVI-7450). This article is published as part of a
   supplement sponsored by the Mediterranean Diet Foundation and the
   Diputacio de Barcelona.
CR Ambrose JA, 2004, J AM COLL CARDIOL, V43, P1731, DOI 10.1016/j.jacc.2003.12.047
   Martín MA, 2010, MOL NUTR FOOD RES, V54, P956, DOI 10.1002/mnfr.200900159
   [Anonymous], 2015, DIABETOLOGIA
   [Anonymous], 2003, WHO TECHN REP SER
   Bayturan O, 2010, ARCH INTERN MED, V170, P478, DOI 10.1001/archinternmed.2009.551
   Berry SEE, 2008, J NUTR, V138, P1910, DOI 10.1093/jn/138.10.1910
   Bogani P, 2007, ATHEROSCLEROSIS, V190, P181, DOI 10.1016/j.atherosclerosis.2006.01.011
   Borissoff JI, 2011, NEW ENGL J MED, V364, P1746, DOI 10.1056/NEJMra1011670
   Bravo-Herrera MD, 2004, NUTR METAB CARDIOVAS, V14, P128, DOI 10.1016/S0939-4753(04)80032-2
   Brunner H, 2005, J HYPERTENS, V23, P233, DOI 10.1097/00004872-200502000-00001
   Buchholz T, 2015, PLANTA MED, V81, P771, DOI 10.1055/s-0035-1546173
   Bulló M, 2011, CURR TOP MED CHEM, V11, P1797, DOI 10.2174/156802611796235062
   Calabriso N, 2016, J NUTR BIOCHEM, V28, P19, DOI 10.1016/j.jnutbio.2015.09.026
   Camargo A, 2012, BRIT J NUTR, V108, P500, DOI 10.1017/S0007114511005812
   Camargo A, 2010, BMC GENOMICS, V11, DOI 10.1186/1471-2164-11-253
   Carluccio MA, 2003, ARTERIOSCL THROM VAS, V23, P622, DOI 10.1161/01.ATV.0000062884.69432.A0
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Covas MI, 2006, ANN INTERN MED, V145, P333, DOI 10.7326/0003-4819-145-5-200609050-00006
   Covas MI, 2009, J CARDIOVASC PHARM, V54, P477, DOI 10.1097/FJC.0b013e3181c5e7fd
   Cruz-Teno C, 2012, MOL NUTR FOOD RES, V56, P854, DOI 10.1002/mnfr.201200096
   D'Alessandro A, 2015, NUTRIENTS, V7, P7863, DOI 10.3390/nu7095367
   Davignon J, 2004, CIRCULATION, V109, P27, DOI 10.1161/01.CIR.0000131515.03336.f8
   de la Torre-Carbot K, 2010, J NUTR, V140, P501, DOI 10.3945/jn.109.112912
   Delgado-Lista J, 2008, AM J CLIN NUTR, V87, P317, DOI 10.1093/ajcn/87.2.317
   Díaz-López A, 2015, DIABETES CARE, V38, P2134, DOI 10.2337/dc15-1117
   Elhayany A, 2010, DIABETES OBES METAB, V12, P204, DOI 10.1111/j.1463-1326.2009.01151.x
   Storniolo CE, 2014, REDOX BIOL, V2, P971, DOI 10.1016/j.redox.2014.07.001
   Esmaillzadeh A, 2007, AM J CLIN NUTR, V85, P910, DOI 10.1093/ajcn/85.3.910
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   Esposito K, 2011, METAB SYNDR RELAT D, V9, P1, DOI 10.1089/met.2010.0031
   Estruch R, 2006, ANN INTERN MED, V145, P1, DOI 10.7326/0003-4819-145-1-200607040-00004
   Estruch R, 2010, P NUTR SOC, V69, P333, DOI 10.1017/S0029665110001539
   Fitó M, 2005, ATHEROSCLEROSIS, V181, P149, DOI 10.1016/j.atherosclerosis.2004.12.036
   Fuentes F, 2008, BRIT J NUTR, V100, P159, DOI 10.1017/S0007114508888708
   Fuentes F, 2001, ANN INTERN MED, V134, P1115, DOI 10.7326/0003-4819-134-12-200106190-00011
   Giordano E, 2014, NUTR METAB CARDIOVAS, V24, P1144, DOI 10.1016/j.numecd.2014.05.003
   Giugliano F, 2010, J SEX MED, V7, P1911, DOI 10.1111/j.1743-6109.2010.01713.x
   Gleissner CA, 2008, ARTERIOSCL THROM VAS, V28, P1920, DOI 10.1161/ATVBAHA.108.169417
   Gutierrez-Mariscal FM, 2012, AGE, V34, P389, DOI 10.1007/s11357-011-9229-1
   Hodge AM, 2011, NUTR METAB CARDIOVAS, V21, P733, DOI 10.1016/j.numecd.2010.10.014
   Hunter KA, 2001, BRIT J NUTR, V86, P207
   Jimenez-Gomez Yolanda, 2009, Atherosclerosis, V204, pe70, DOI 10.1016/j.atherosclerosis.2008.09.011
   Karantonis HC, 2006, DIABETES RES CLIN PR, V72, P33, DOI 10.1016/j.diabres.2005.09.003
   Karantonis HC, 2002, J AGR FOOD CHEM, V50, P1150, DOI 10.1021/jf010923t
   Kelly CNM, 2001, P NUTR SOC, V60, P161, DOI 10.1079/PNS200087
   Kolovou GD, 2011, CURR VASC PHARMACOL, V9, P258
   Konstantinidou V, 2009, OMICS, V13, P431, DOI 10.1089/omi.2008.0085
   KOZIMA Y, 1993, THROMB RES, V70, P191, DOI 10.1016/0049-3848(93)90159-L
   Langsted A, 2011, J INTERN MED, V270, P65, DOI 10.1111/j.1365-2796.2010.02333.x
   Larsen LF, 1999, AM J CLIN NUTR, V70, P976
   Larsen LF, 1997, ARTERIOSCL THROM VAS, V17, P2904, DOI 10.1161/01.ATV.17.11.2904
   Lercker G, 2000, J CHROMATOGR A, V881, P105, DOI 10.1016/S0021-9673(00)00455-6
   Lievens D, 2009, THROMB HAEMOSTASIS, V102, P206, DOI 10.1160/TH09-01-0029
   Llorente-Cortés V, 2010, ATHEROSCLEROSIS, V208, P442, DOI 10.1016/j.atherosclerosis.2009.08.004
   Lockyer S, 2017, EUR J NUTR, V56, P1421, DOI 10.1007/s00394-016-1188-y
   Loffredo L, 2017, BRIT J CLIN PHARMACO, V83, P96, DOI 10.1111/bcp.12923
   López S, 2008, AM J CLIN NUTR, V88, P638, DOI 10.1093/ajcn/88.3.638
   López-Miranda J, 2010, NUTR METAB CARDIOVAS, V20, P284, DOI 10.1016/j.numecd.2009.12.007
   Loued S, 2013, BRIT J NUTR, V110, P1272, DOI 10.1017/S0007114513000482
   Lucas L, 2011, CURR PHARM DESIGN, V17, P754, DOI 10.2174/138161211795428911
   Lutsey PL, 2008, CIRCULATION, V117, P754, DOI 10.1161/CIRCULATIONAHA.107.716159
   Marin C, 2011, AM J CLIN NUTR, V93, P267, DOI 10.3945/ajcn.110.006866
   Martínez-González MA, 2008, BMJ-BRIT MED J, V336, P1348, DOI 10.1136/bmj.39561.501007.BE
   Meisinger C, 2005, CIRCULATION, V112, P651, DOI 10.1161/CIRCULATIONAHA.104.529297
   Mena MP, 2009, AM J CLIN NUTR, V89, P248, DOI 10.3945/ajcn.2008.26094
   Mihas C, 2011, CURR VASC PHARMACOL, V9, P271, DOI 10.2174/157016111795495530
   Misikangas M, 2001, J NUTR, V131, P1700, DOI 10.1093/jn/131.6.1700
   Moreno JJ, 2003, FREE RADICAL BIO MED, V35, P1073, DOI 10.1016/S0891-5849(03)00465-9
   Motton DD, 2005, THROMB HAEMOSTASIS, V94, P504, DOI 10.1160/TH04-12-0826
   Owen RW, 2000, FOOD CHEM TOXICOL, V38, P647, DOI 10.1016/S0278-6915(00)00061-2
   Panagiotakos DB, 2004, AM HEART J, V147, P106, DOI 10.1016/S0002-8703(03)00442-3
   Paniagua JA, 2007, DIABETES CARE, V30, P1717, DOI 10.2337/dc06-2220
   Pérez-Jiménez F, 1999, ATHEROSCLEROSIS, V145, P351, DOI 10.1016/S0021-9150(99)00116-1
   Pérez-Jiménez F, 2007, MOL NUTR FOOD RES, V51, P1199, DOI [10.1002/mnfr.200600273, 10.1002/mnfr.200790023]
   Pérez-Martínez P, 2011, CURR PHARM DESIGN, V17, P769, DOI 10.2174/138161211795428948
   Perez-Martinez P, 2010, CLIN SCI, V119, P251, DOI 10.1042/CS20100015
   Pignatelli P, 2015, CLIN NUTR, V34, P899, DOI 10.1016/j.clnu.2014.09.011
   Poppitt SD, 2004, EUR J CLIN NUTR, V58, P819, DOI 10.1038/sj.ejcn.1601882
   Rader DJ, 2009, J LIPID RES, V50, pS189, DOI 10.1194/jlr.R800088-JLR200
   Ramírez-Tortosa MC, 1999, CLIN NUTR, V18, P167, DOI 10.1016/S0261-5614(99)80007-7
   Reisin E, 2010, CURR HYPERTENS REP, V12, P56, DOI 10.1007/s11906-010-0102-x
   Ryu SJ, 2015, J AGR FOOD CHEM, V63, P2098, DOI 10.1021/jf505894b
   Salas-Salvadó J, 2008, EUR J CLIN NUTR, V62, P651, DOI 10.1038/sj.ejcn.1602762
   Sanders TAB, 2003, BRIT J NUTR, V89, P767, DOI 10.1079/BJN2003850
   Sanders TAB, 2000, ATHEROSCLEROSIS, V149, P413, DOI 10.1016/S0021-9150(99)00335-4
   Schwartz GJ, 2008, CELL METAB, V8, P281, DOI 10.1016/j.cmet.2008.08.005
   Scoditti E, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0128218
   Scoditti E, 2012, ARCH BIOCHEM BIOPHYS, V527, P81, DOI 10.1016/j.abb.2012.05.003
   Silva KDR, 2003, ATHEROSCLEROSIS, V166, P73, DOI 10.1016/S0021-9150(02)00306-4
   Smith RD, 2003, BRIT J NUTR, V90, P597, DOI 10.1079/BJN2003953
   Solfrizzi V, 2011, EXPERT REV NEUROTHER, V11, P677, DOI [10.1586/ERN.11.56, 10.1586/ern.11.56]
   Tedgui A, 2006, PHYSIOL REV, V86, P515, DOI 10.1152/physrev.00024.2005
   Tortosa A, 2007, DIABETES CARE, V30, P2957, DOI 10.2337/dc07-1231
   TREMOLI E, 1994, WORLD REV NUTR DIET, V76, P55
   Trichopoulou A, 2007, FOOD NUTR BULL, V28, P236, DOI 10.1177/156482650702800213
   Tripoli E, 2005, NUTR RES REV, V18, P98, DOI 10.1079/NRR200495
   Venturini D, 2015, NUTRITION, V31, P834, DOI 10.1016/j.nut.2014.12.016
   Vicario IM, 1998, ANN NUTR METAB, V42, P160, DOI 10.1159/000012729
   Visioli F, 2002, MED RES REV, V22, P65, DOI 10.1002/med.1028
   Visioli F, 2000, BIOCHEM BIOPH RES CO, V278, P797, DOI 10.1006/bbrc.2000.3879
   Weinbrenner T, 2004, J NUTR, V134, P2314, DOI 10.1093/jn/134.9.2314
   Yubero-Serrano EM, 2013, AGE, V35, P159, DOI 10.1007/s11357-011-9331-4
   Yubero-Serrano EM, 2012, J GERONTOL A-BIOL, V67, P3, DOI 10.1093/gerona/glr167
   Yubero-Serrano EM, 2011, J AM GERIATR SOC, V59, P938, DOI 10.1111/j.1532-5415.2011.03381.x
   Yubero-Serrano EM, 2011, AGE, V33, P579, DOI 10.1007/s11357-010-9199-8
   Zrelli H, 2011, J AGR FOOD CHEM, V59, P4473, DOI 10.1021/jf104151d
NR 106
TC 153
Z9 160
U1 1
U2 39
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0954-3007
EI 1476-5640
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PY 2019
VL 72
SU S
BP 8
EP 17
DI 10.1038/s41430-018-0304-x
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics
GA JC2ML
UT WOS:000489111000013
PM 30487558
DA 2025-06-11
ER

PT J
AU Cordero, MD
   Cotán, D
   del-Pozo-Martín, Y
   Carrión, AM
   de Miguel, M
   Bullón, P
   Sánchez-Alcazar, JA
AF Cordero, Mario D.
   Cotan, David
   del-Pozo-Martin, Yaiza
   Carrion, Angel M.
   de Miguel, Manuel
   Bullon, Pedro
   Antonio Sanchez-Alcazar, Jose
TI Oral coenzyme Q10 supplementation improves clinical symptoms and
   recovers pathologic alterations in blood mononuclear cells in a
   fibromyalgia patient
SO NUTRITION
LA English
DT Article
DE Fibromyalgia; Coenzyme Q; Mitochondrial biogenesis; Oxidative stress
ID MITOCHONDRIAL DYSFUNCTION; METABOLIC SYNDROME; COPY NUMBER; DNA
AB Fibromyalgia (FM) is a chronic pain syndrome with unknown etiology. Recent studies have shown evidence demonstrating that mitochondrial dysfunction and oxidative stress may have a role in the pathophysiology of FM. Coenzyme Q10 (CoQ10) is an essential electron carrier in the mitochondrial respiratory chain and a strong antioxidant. Low CoQ10 levels have been detected in patients with FM, and a significant decrease of clinical symptoms has been reported after oral CoQ10 supplementation. In this report, we show the effect of CoQ10 treatment on clinical symptoms, blood mononuclear cells, and mitochondrial and oxidative stress markers from a woman with FM. After CoQ10 treatment, the patient reported a significant improvement of clinical symptoms. At the cellular level, CoQ10 treatment restored mitochondrial dysfunction and the mtDNA copy number, decreased oxidative stress, and increased mitochondrial biogenesis. Our results suggest that CoQ10 could be an alternative therapeutic approach for FM. Crown Copyright (C) 2012 Published by Elsevier Inc. All rights reserved.
C1 [Cordero, Mario D.; Cotan, David; Antonio Sanchez-Alcazar, Jose] Univ Pablo Olavide, CSIC Junta Andalucia, Ctr Andaluz Biol Desarrollo, Seville, Spain.
   [Cordero, Mario D.; Cotan, David; Antonio Sanchez-Alcazar, Jose] ISCIII, Ctr Invest Biomed Red Enfermedades Raras, Seville, Spain.
   [Cordero, Mario D.; de Miguel, Manuel] Univ Seville, Fac Med, Dept Citol & Histol Normal & Patol, Seville, Spain.
   [del-Pozo-Martin, Yaiza; Carrion, Angel M.] Univ Pablo Olavide Sevilla, Div Neurociencias, Seville, Spain.
   [Bullon, Pedro] Univ Seville, Fac Odontol, Dpto Periodontl, Seville, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); Universidad
   Pablo de Olavide; CSIC - Andalusian Center for Developmental Biology
   (CABD); Instituto de Salud Carlos III; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERER; University of Sevilla; Universidad Pablo de
   Olavide; University of Sevilla
RP Cordero, MD (corresponding author), Univ Pablo Olavide, CSIC Junta Andalucia, Ctr Andaluz Biol Desarrollo, Seville, Spain.
EM mdcormor@upo.es
RI De-Miguel, Manuel/B-3713-2017; Bullon, Pedro/E-6319-2010; Cordero, Mario
   D./L-8006-2014; Carrion Rodriguez, Angel Manuel/K-5875-2014;
   Sanchez-Alcazar, Jose A./L-4925-2014
OI De-Miguel, Manuel/0000-0002-6751-1695; Bullon,
   Pedro/0000-0003-4873-4196; Cordero, Mario D./0000-0003-0151-3644; del
   Pozo Martin, Yaiza/0000-0002-8053-6256; Carrion Rodriguez, Angel
   Manuel/0000-0001-8158-9512; Sanchez-Alcazar, Jose A./0000-0001-9705-1469
FU Servicio Andaluz de Salud [FIS PI10/00543, FIS EC08/00076, SAS 111242];
   Asociacion de Enfermos de Patologia Mitocondrial; Federacion Andaluza de
   Fibromialgia y Fatiga Cronica (ALBA Andalucia)
FX This group was founded by the Centro de Investigacion Biomedica en Red
   de Enfermedades Raras, ISCIII. This work was supported by grants FIS
   PI10/00543, FIS EC08/00076, and SAS 111242 from the Servicio Andaluz de
   Salud, the Asociacion de Enfermos de Patologia Mitocondrial, and the
   Federacion Andaluza de Fibromialgia y Fatiga Cronica (ALBA Andalucia).
CR Adhihetty PJ, 2007, AM J PHYSIOL-ENDOC M, V293, pE672, DOI 10.1152/ajpendo.00043.2007
   Cordero MD, 2011, MITOCHONDRION, V11, P623, DOI 10.1016/j.mito.2011.03.122
   Cordero MD, 2010, CLIN BIOCHEM, V43, P1174, DOI 10.1016/j.clinbiochem.2010.06.013
   Cordero MD, 2010, ARTHRITIS RES THER, V12, DOI 10.1186/ar2918
   DeSouza RA, 2004, SOUTH MED J, V97, P528, DOI 10.1097/00007611-200405000-00023
   Glass JM, 2009, RHEUM DIS CLIN N AM, V35, P299, DOI 10.1016/j.rdc.2009.06.002
   Huang CH, 2011, J ATHEROSCLER THROMB, V18, P867, DOI 10.5551/jat.8698
   Lee JW, 2010, CLIN CHIM ACTA, V411, P592, DOI 10.1016/j.cca.2010.01.024
   Lenaz G, 2007, MITOCHONDRION, V7, pS8, DOI 10.1016/j.mito.2007.03.009
   Lister RE, 2002, J INT MED RES, V30, P195, DOI 10.1177/147323000203000213
   Liu CS, 2006, ACTA NEUROL SCAND, V113, P334, DOI 10.1111/j.1600-0404.2006.00586.x
   Loevinger BL, 2007, METABOLISM, V56, P87, DOI 10.1016/j.metabol.2006.09.001
   Quinzii CM, 2008, BIOFACTORS, V32, P113, DOI 10.1002/biof.5520320113
   RAUCHOVA H, 1992, J BIOENERG BIOMEMBR, V24, P235, DOI 10.1007/BF00762682
   Tomasetti M, 2001, FASEB J, V15, P1425, DOI 10.1096/fj.00-0694fje
   Villanova M, 1999, MUSCLE NERVE, V22, P289, DOI 10.1002/(SICI)1097-4598(199902)22:2<289::AID-MUS26>3.0.CO;2-O
   WOLFE F, 1990, ARTHRITIS RHEUM-US, V33, P160, DOI 10.1002/art.1780330203
NR 17
TC 40
Z9 42
U1 0
U2 18
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0899-9007
J9 NUTRITION
JI Nutrition
PD NOV-DEC
PY 2012
VL 28
IS 11-12
BP 1200
EP 1203
DI 10.1016/j.nut.2012.03.018
PG 4
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 028BI
UT WOS:000310397400024
PM 22898267
DA 2025-06-11
ER

PT J
AU Cardona, F
   Túnez, I
   Tasset, I
   Garrido-Sánchez, L
   Collantes, E
   Tinahones, FJ
AF Cardona, Fernando
   Tunez, Isaac
   Tasset, Inmaculada
   Garrido-Sanchez, Lourdes
   Collantes, Eduardo
   Tinahones, Francisco Jose
TI Circulating antioxidant defences are decreased in healthy people after a
   high-fat meal
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE uric acid; oxidative stress; postprandial hyperlipidaemia; high-fat meal
ID URIC-ACID; OXIDATIVE STRESS; RENAL EXCRETION; ENDOTHELIAL FUNCTION;
   PLASMA; CAPACITY; DISEASE; URATE; RISK
AB The aim of this study was to examine the responses of uric acid, antioxidant defences and pro-oxidant variables after a high-fat meal. Twenty-five healthy persons without criteria for the metabolic syndrome, underwent a high-fat meal with Supracal (R) (60 g fat). Measurements were made at baseline and 3 h after the meal of TAG, uric acid, HDL-cholesterol, total proteins and oxidative stress. Following the high-fat meal, we detected a significant increase in pro-oxidative variables and a decrease in antioxidative variables. The uric acid concentrations were significantly lower after the high-fat meal and the reduction correlated significantly with the oxidative stress variables. The inverse relation between reduced uric acid and increased carbonylated proteins remained in multiple regression analysis. We conclude that uric acid is a powerful antioxidant and its reduction following a high-fat meal may be related with its acute antioxidative action.
C1 [Cardona, Fernando; Garrido-Sanchez, Lourdes; Tinahones, Francisco Jose] Univ Virgen Victoria, Hosp Clin, Serv Endocrinol & Nutr, Malaga 29009, Spain.
   [Cardona, Fernando; Garrido-Sanchez, Lourdes; Tinahones, Francisco Jose] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CB06 03, Malaga 29009, Spain.
   [Tunez, Isaac; Tasset, Inmaculada] Univ Cordoba, Fac Med, Dept Bioquim & Biol Mol, E-14071 Cordoba, Spain.
   [Collantes, Eduardo] Univ Cordoba, Serv Reumatol, Hosp Univ Reina Sofia Cordoba, E-14004 Cordoba, Spain.
   [Collantes, Eduardo] Univ Cordoba, Dept Med, E-14004 Cordoba, Spain.
C3 Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica
   en Red; CIBEROBN; Universidad de Cordoba; Hospital Universitario Reina
   Sofia - Cordoba; Universidad de Cordoba; Universidad de Cordoba
RP Tinahones, FJ (corresponding author), Univ Virgen Victoria, Hosp Clin, Serv Endocrinol & Nutr, Malaga 29009, Spain.
EM fjtinahones@terra.es
RI Tinahones, Francisco/AAB-2882-2020; Cardona, Fernando/AAG-7835-2019;
   Cuevas, Inmaculada/R-4509-2019; Collantes-Estevez, Eduardo/M-9549-2019;
   Cardona, Fernando/H-6022-2015
OI Collantes Estevez, Eduardo/0000-0002-7647-6289; Tinahones, Francisco
   J/0000-0001-6871-4403; Cardona, Fernando/0000-0003-4460-6824
CR AEBI H, 1984, METHOD ENZYMOL, V105, P121
   AMES BN, 1981, P NATL ACAD SCI-BIOL, V78, P6858, DOI 10.1073/pnas.78.11.6858
   Bae JH, 2001, ATHEROSCLEROSIS, V155, P517, DOI 10.1016/S0021-9150(00)00601-8
   Benzie IFF, 1999, CLIN CHEM, V45, P901
   Berry CE, 2004, J PHYSIOL-LONDON, V555, P589, DOI 10.1113/jphysiol.2003.055913
   Bowen Phyllis E, 2004, Curr Atheroscler Rep, V6, P477, DOI 10.1007/s11883-004-0089-3
   Cardona F, 2005, ANN RHEUM DIS, V64, P85, DOI 10.1136/ard.2003.019695
   Cardona F, 2003, RHEUMATOLOGY, V42, P468, DOI 10.1093/rheumatology/keg166
   Cardona F, 2006, ENDOCRINOL NUTR, V53, P345
   DAVIES KJA, 1986, BIOCHEM J, V235, P747, DOI 10.1042/bj2350747
   de Koning EJP, 2002, ATHEROSCLEROSIS SUPP, V3, P11, DOI 10.1016/S1567-5688(01)00008-3
   FLOHE L, 1984, METHOD ENZYMOL, V105, P114
   Franse LV, 2000, J HYPERTENS, V18, P1149, DOI 10.1097/00004872-200018080-00021
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Glantzounis GK, 2005, CURR PHARM DESIGN, V11, P4145, DOI 10.2174/138161205774913255
   HALLIWELL B, 1999, FREE RADICAL BIO MED, P195
   HOEY BM, 1984, BIOCHIM BIOPHYS ACTA, V791, P212
   KARPE F, 1994, ATHEROSCLEROSIS, V106, P83, DOI 10.1016/0021-9150(94)90085-X
   KAUR H, 1990, CHEM-BIOL INTERACT, V73, P235, DOI 10.1016/0009-2797(90)90006-9
   Lapenna D, 1998, CIRCULATION, V97, P1930, DOI 10.1161/01.CIR.97.19.1930
   LEVINE RL, 1990, METHOD ENZYMOL, V186, P464
   Lohman TG, 1988, Anthropometric Standardization Reference Manual. Abridged Edition
   Manuel-y-Keenoy B, 2005, J AM COLL NUTR, V24, P474, DOI 10.1080/07315724.2005.10719493
   MARKLUND SL, 1990, METHOD ENZYMOL, V186, P260
   Maxwell SRJ, 1997, EUR J CLIN INVEST, V27, P484, DOI 10.1046/j.1365-2362.1997.1390687.x
   Mikami T, 2000, FREE RADICAL RES, V32, P31, DOI 10.1080/10715760000300041
   Nieto FJ, 2000, ATHEROSCLEROSIS, V148, P131, DOI 10.1016/S0021-9150(99)00214-2
   PATSCH JR, 1992, ARTERIOSCLER THROMB, V12, P1336, DOI 10.1161/01.ATV.12.11.1336
   PORTER M, 1992, CLIN SCI, V83, P343, DOI 10.1042/cs0830343
   Ricart-Jané D, 2002, NITRIC OXIDE-BIOL CH, V6, P178, DOI 10.1006/niox.2001.0392
   Roxborough HE, 1999, NEPHRON, V81, P278, DOI 10.1159/000045293
   TINAHONES FJ, 1995, BRIT J RHEUMATOL, V34, P920
   Tinahones JF, 1997, J CLIN ENDOCR METAB, V82, P1188, DOI 10.1210/jc.82.4.1188
   Ursini F, 2002, BIOL CHEM, V383, P599, DOI 10.1515/BC.2002.062
   Waring WS, 2003, CLIN SCI, V105, P425, DOI 10.1042/CS20030149
   Waring WS, 2001, J CARDIOVASC PHARM, V38, P365, DOI 10.1097/00005344-200109000-00005
   Watanabe S, 2002, HYPERTENSION, V40, P355, DOI 10.1161/01.HYP.0000028589.66335.AA
   Yu ZF, 1998, J NEUROSCI RES, V53, P613, DOI 10.1002/(SICI)1097-4547(19980901)53:5<613::AID-JNR11>3.0.CO;2-1
NR 38
TC 21
Z9 22
U1 0
U2 3
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD AUG
PY 2008
VL 100
IS 2
BP 312
EP 316
DI 10.1017/S0007114507894347
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 330OF
UT WOS:000257952000012
PM 18184452
OA Bronze
DA 2025-06-11
ER

PT J
AU Lee, H
   Im, SW
   Jung, CH
   Jang, YJ
   Ha, TY
   Ahn, J
AF Lee, Hyunjung
   Im, Sung Won
   Jung, Chang Hwa
   Jang, Young Jin
   Ha, Tae Youl
   Ahn, Jiyun
TI Tyrosol, an olive oil polyphenol, inhibits ER stress-induced apoptosis
   in pancreatic β-cell through JNK signaling
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Tyrosol; ER stress; beta-Cell failure; Apoptosis; NIT-1
ID ENDOPLASMIC-RETICULUM STRESS; ACTIVATION; FAILURE; LINE; PERK
AB Dysfunction of pancreatic beta-cell is a major determinant for the development of type 2 diabetes. Because of the stimulated insulin secretion in metabolic syndrome, endoplasmic reticulum (ER) stress plays a central mediator for beta-cell failure. In this study, we investigated whether an antioxidant phenolic compound, tyrosol protects against beta-cell dysfunction associated with ER stress. To address this issue, we exposed pancreatic beta cells, NIT-1 to tunicamycin with tyrosol. We found tyrosol diminished tunicamycin-induced cell death in a dose-dependent manner. We also detected tyrosol decreased the expressions of apoptosis-related markers. Exposure to tunicamycin evoked UPR response and co-treatment of tyrosol led to reduction of ER stress. These effects of tyrosol were mediated by the phosphorylation of JNK. Moreover, we confirmed supplement of tyrosol ameliorated beta-cell loss induced by high fat feeding. Taken together, our study provides a molecular basis for signaling transduction of protective effect of tyrosol against ER stress-induced beta-cell death. Therefore, we suggest tyrosol could be a potential therapeutic candidate for amelioration of type 2 diabetes. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Lee, Hyunjung; Im, Sung Won; Jung, Chang Hwa; Jang, Young Jin; Ha, Tae Youl; Ahn, Jiyun] Korea Food Res Inst, Res Grp Metab Mech, 1201-62 Anyangpangyo Ro, Songnam 13539, Gyeonggi, South Korea.
   [Jung, Chang Hwa; Ha, Tae Youl; Ahn, Jiyun] Univ Sci & Technol, Div Food Biotechnol, Daejeon 34113, South Korea.
C3 Korea Food Research Institute (KFRI); University of Science & Technology
   (UST)
RP Ahn, J (corresponding author), Korea Food Res Inst, Res Grp Metab Mech, 1201-62 Anyangpangyo Ro, Songnam 13539, Gyeonggi, South Korea.
EM jyan@kfri.re.kr
RI Jang, Young/AAT-1192-2020
OI Jang, Young Jin/0000-0003-0553-2498
FU Korea Food Research Institute [E0143033654]
FX This work was supported by Korea Food Research Institute (#E0143033654).
CR Aguirre V, 2000, J BIOL CHEM, V275, P9047, DOI 10.1074/jbc.275.12.9047
   Ahn J, 2010, AM J PHYSIOL-CELL PH, V298, pC1510, DOI 10.1152/ajpcell.00369.2009
   Boselli E, 2006, ANAL CHIM ACTA, V563, P93, DOI 10.1016/j.aca.2005.10.024
   Carluccio MA, 2003, ARTERIOSCL THROM VAS, V23, P622, DOI 10.1161/01.ATV.0000062884.69432.A0
   Chandramohan R, 2015, CHEM-BIOL INTERACT, V229, P44, DOI 10.1016/j.cbi.2015.01.026
   왕승진, 2012, [Korean Journal of Food Science and Technology, 한국식품과학회지], V44, P14
   Cnop M, 2008, BIOCHEM SOC T, V36, P909, DOI 10.1042/BST0360909
   Eizirik DL, 2010, SCI SIGNAL, V3, DOI 10.1126/scisignal.3110pe7
   FernandesAlnemri T, 1996, P NATL ACAD SCI USA, V93, P7464, DOI 10.1073/pnas.93.15.7464
   Fitó M, 2000, LIPIDS, V35, P633, DOI 10.1007/s11745-000-0567-1
   Giovannini C, 1999, J NUTR, V129, P1269, DOI 10.1093/jn/129.7.1269
   Ha BG, 2013, MAR DRUGS, V11, P4193, DOI 10.3390/md11114193
   HAMAGUCHI K, 1991, DIABETES, V40, P842, DOI 10.2337/diabetes.40.7.842
   Harding HP, 2001, MOL CELL, V7, P1153, DOI 10.1016/S1097-2765(01)00264-7
   Harding HP, 2000, MOL CELL, V5, P897, DOI 10.1016/S1097-2765(00)80330-5
   Hitomi J, 2004, NEUROSCI LETT, V357, P127, DOI 10.1016/j.neulet.2003.12.080
   Lee AH, 2003, MOL CELL BIOL, V23, P7448, DOI 10.1128/MCB.23.21.7448-7459.2003
   Matsumoto M, 1996, FEBS LETT, V395, P143, DOI 10.1016/0014-5793(96)01016-2
   McCullough KD, 2001, MOL CELL BIOL, V21, P1249, DOI 10.1128/MCB.21.4.1249-1259.2001
   Melloul D, 2002, DIABETOLOGIA, V45, P309, DOI 10.1007/s00125-001-0728-y
   PETRONI A, 1995, THROMB RES, V78, P151, DOI 10.1016/0049-3848(95)00043-7
   Prentki M, 2006, J CLIN INVEST, V116, P1802, DOI 10.1172/JCI29103
   Roat R, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0086815
   Salas-Salvadó J, 2011, DIABETES CARE, V34, P14, DOI 10.2337/dc10-1288
   Salucci S, 2015, J DERMATOL SCI, V80, P61, DOI 10.1016/j.jdermsci.2015.07.002
   Scheuner D, 2008, ENDOCR REV, V29, P317, DOI 10.1210/er.2007-0039
   Schröder M, 2005, ANNU REV BIOCHEM, V74, P739, DOI 10.1146/annurev.biochem.73.011303.074134
   Srinivasan S, 2005, DIABETES, V54, P968, DOI 10.2337/diabetes.54.4.968
   UNGER RH, 1995, DIABETES, V44, P863, DOI 10.2337/diabetes.44.8.863
   Urano F, 2000, SCIENCE, V287, P664, DOI 10.1126/science.287.5453.664
   Violi F, 2015, NUTR DIABETES, V5, DOI 10.1038/nutd.2015.23
NR 31
TC 28
Z9 32
U1 1
U2 26
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD JAN 15
PY 2016
VL 469
IS 3
BP 748
EP 752
DI 10.1016/j.bbrc.2015.12.036
PG 5
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA DC6TP
UT WOS:000369352800065
PM 26692476
DA 2025-06-11
ER

PT J
AU Iijima, K
   Iimuro, S
   Ohashi, Y
   Sakurai, T
   Umegaki, H
   Araki, A
   Yoshimura, Y
   Ouchi, Y
   Ito, H
AF Iijima, Katsuya
   Iimuro, Satoshi
   Ohashi, Yasuo
   Sakurai, Takashi
   Umegaki, Hiroyuki
   Araki, Atsushi
   Yoshimura, Yukio
   Ouchi, Yasuyoshi
   Ito, Hideki
CA Japanese Elderly Diabet Interventi
TI Lower physical activity, but not excessive calorie intake, is associated
   with metabolic syndrome in elderly with type 2 diabetes mellitus: The
   Japanese elderly diabetes intervention trial
SO GERIATRICS & GERONTOLOGY INTERNATIONAL
LA English
DT Article
DE depression; elderly; excessive calorie intake; Japanese Elderly Diabetes
   Intervention Trial study; metabolic syndrome; physical activity; work
   activity
ID CORONARY-HEART-DISEASE; RANDOMIZED CONTROLLED-TRIAL; DEPRESSIVE
   SYMPTOMS; GENERAL-PRACTICE; RISK; PEOPLE; FEDERATION; MORTALITY
AB Aim: A decline in physical activity has been shown to be associated with metabolic syndrome (MetS), leading to cardiovascular events. However, this is difficult to manage well in the elderly with multiple atherosclerotic risk factors. In this study, we investigated the correlation between physical activity and clinical parameters in the presence and absence of MetS in Japanese elderly subjects with type 2 diabetes mellitus (T2DM). In addition, we determined which factor, calorie intake or physical activity, mainly contributes to the prevalence of MetS.
   Methods: Cross- sectional analysis of 846 consecutive Japanese elderly (408 men and 438 women, mean age 68.7 years) was carried out at the time of enrolment (2000-2002) in the Japanese Elderly Diabetes Intervention Trial. Their level of physical activity was evaluated using the Baecke questionnaire, consisting of three components: work, sports and leisure. Total activity score (TAS) as the sum of each activity score was divided into four quartiles (Q1 to Q4).
   Results: After adjustment for age and sex, there was a positive association of TAS with high-density lipoprotein cholesterol, although no significant correlation between other lipid parameters and TAS was found. In addition, fasting plasma glucose, insulin level and physical measurements, such as waist circumference, waist/hip ratio and body mass index, were inversely associated with TAS. Although no correlation between TAS and cognitive function Mini- Mental State Examination was found, TAS was positively associated with instrumental ADL and negatively associated with geriatric depression score (GDS), suggesting that a decline in physical activity in the elderly is associated with depressed mood rather than a decline of cognitive function. Total calorie intake appeared to increase according to TAS; however, this did not reach statistical significance. In a subanalysis comparing the presence and absence of MetS, the TAS grade in the MetS group was significantly lower than that in the non- MetS group, although there was no significant difference in total calorie intake between the groups.
   Conclusion: These results showed that lower physical activity, but not excessive calorie intake, is independently associated with the prevalence of MetS in the elderly with T2DM. In our routine work, encouraging physical activity might contribute to preventing MetS and subsequent atherosclerotic disease in the elderly, rather than strict management of abnormal laboratory parameters using multiple drugs. Geriatr Gerontol Int 2012; 12 (Suppl. 1): 68-76.
C1 [Iijima, Katsuya] Univ Tokyo, Dept Geriatr Med, Grad Sch Med, Bunkyo Ku, Tokyo 1138655, Japan.
   [Iijima, Katsuya] Univ Tokyo, Inst Gerontol, Tokyo 1138655, Japan.
   [Iimuro, Satoshi; Ohashi, Yasuo] Univ Tokyo, Grad Sch Med, Sch Publ Hlth, Dept Biostat, Tokyo 1138655, Japan.
   [Sakurai, Takashi] Natl Ctr Geriatr & Gerontol, Ctr Comprehens Care & Res Demented Disorders, Oobu, Aichi, Japan.
   [Sakurai, Takashi] Kobe Univ, Grad Sch Med, Dept Geriatr Med, Kobe, Hyogo 657, Japan.
   [Umegaki, Hiroyuki] Nagoya Univ, Grad Sch Med, Dept Community Healthcare & Geriatr, Nagoya, Aichi 4648601, Japan.
   [Araki, Atsushi; Ito, Hideki] Tokyo Metropolitan Geriatr Hosp, Dept Diabet Metab & Endocrinol, Tokyo 173, Japan.
   [Yoshimura, Yukio] Shikoku Univ, Fac Human Life Sci, Training Dept Adm Dietitians, Tokushima, Japan.
C3 University of Tokyo; University of Tokyo; University of Tokyo; National
   Center for Geriatrics & Gerontology; Kobe University; Nagoya University;
   Tokyo Metropolitan Institute of Gerontology
RP Iijima, K (corresponding author), Univ Tokyo, Dept Geriatr Med, Grad Sch Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM katsu-tky@umin.ac.jp
RI Araki, Atsushi/JVE-0081-2024
OI Araki, Atsushi/0000-0001-9088-2841
FU Ministry of Health and Labour, and Welfare [H12-Choju-016,
   H15-Chojyu-016, H17-Choju-Ordinal-013]; Japan Foundation for Aging and
   Health
FX The registration number for this clinical trial was UMIN000000890. This
   study was financially supported by Research Grants for Longevity
   Sciences from the Ministry of Health and Labour, and Welfare
   (H12-Choju-016, H15-Chojyu-016, H17-Choju-Ordinal-013) and the Japan
   Foundation for Aging and Health.
CR Akisaki T, 2006, DIABETES-METAB RES, V22, P376, DOI 10.1002/dmrr.632
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Anuurad E, 2003, J OCCUP HEALTH, V45, P335, DOI 10.1539/joh.45.335
   Athyros VG, 2005, CURR MED RES OPIN, V21, P1157, DOI 10.1185/030079905X53333
   BAECKE JAH, 1982, AM J CLIN NUTR, V36, P936
   Bauman A E, 2004, J Sci Med Sport, V7, P6, DOI 10.1016/S1440-2440(04)80273-1
   BERLIN JA, 1990, AM J EPIDEMIOL, V132, P612, DOI 10.1093/oxfordjournals.aje.a115704
   Bonnet F, 2005, ATHEROSCLEROSIS, V178, P339, DOI 10.1016/j.atherosclerosis.2004.08.035
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Hemingway H, 1999, BMJ-BRIT MED J, V318, P1460, DOI 10.1136/bmj.318.7196.1460
   Hirose Takahisa, 2005, Curr Diab Rep, V5, P226, DOI 10.1007/s11892-005-0013-4
   Kerse NM, 1999, BMJ-BRIT MED J, V319, P683, DOI 10.1136/bmj.319.7211.683
   KOYANO W, 1991, ARCH GERONTOL GERIAT, V13, P103, DOI 10.1016/0167-4943(91)90053-S
   McNeill AM, 2006, J AM GERIATR SOC, V54, P1317, DOI 10.1111/j.1532-5415.2006.00862.x
   OHKUBO Y, 1995, DIABETES RES CLIN PR, V28, P103, DOI 10.1016/0168-8227(95)01064-K
   Pinto BM, 2005, AM J PREV MED, V29, P247, DOI 10.1016/j.amepre.2005.06.016
   Pitsavos C, 2005, EUR J CARDIOV PREV R, V12, P151, DOI 10.1097/00149831-200504000-00010
   POWELL KE, 1987, ANNU REV PUBL HEALTH, V8, P253, DOI 10.1146/annurev.publhealth.8.1.253
   Sakurai T, 2010, GERONTOLOGY, V56, P141, DOI 10.1159/000246970
   SHERMAN SE, 1994, AM HEART J, V128, P879, DOI 10.1016/0002-8703(94)90583-5
   Shichiri M, 2000, DIABETES CARE, V23, pB21
   Steptoe A, 1999, BRIT MED J, V319, P943, DOI 10.1136/bmj.319.7215.943
   Tong PC, 2007, DIABETES CARE, V30, P1206, DOI 10.2337/dc06-1484
   Van der Kooy K, 2007, INT J GERIATR PSYCH, V22, P613, DOI 10.1002/gps.1723
   van Gool CH, 2003, AGE AGEING, V32, P81, DOI 10.1093/ageing/32.1.81
   Wannamethee SG, 1998, LANCET, V351, P1603, DOI 10.1016/S0140-6736(97)12355-8
   WHO Study Group on Epidemiology and Prevention of Cardiovascular Diseases in the Elderly, 1995, WHO TECHNI REP SER
   Wulsin LR, 2003, PSYCHOSOM MED, V65, P201, DOI 10.1097/01.PSY.0000058371.50240.E3
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
NR 30
TC 16
Z9 19
U1 1
U2 26
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1444-1586
EI 1447-0594
J9 GERIATR GERONTOL INT
JI Geriatr. Gerontol. Int.
PD APR
PY 2012
VL 12
SU 1
SI SI
BP 68
EP 76
DI 10.1111/j.1447-0594.2011.00814.x
PG 9
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 912DW
UT WOS:000301775900008
PM 22435942
DA 2025-06-11
ER

PT J
AU Park, CG
   Lee, SH
   Chu, MK
AF Park, Chae Gyu
   Lee, Sue Hyun
   Chu, Min Kyung
TI No change in interictal C-reactive protein levels in individuals with
   episodic and chronic migraine: A case-control study and literature
   review
SO FRONTIERS IN NEUROLOGY
LA English
DT Review
DE biomarker; C-reactive protein; inflammation; migraine; headache
ID MAJOR DEPRESSIVE DISORDER; ACUTE-PHASE PROTEINS; CARDIOVASCULAR-DISEASE;
   ENDOTHELIAL FUNCTION; INSULIN-RESISTANCE; METABOLIC SYNDROME; PROBABLE
   MIGRAINE; SEX-DIFFERENCES; SERUM-LEVELS; BIOMARKERS
AB ObjectivesThe levels of some migraine biomarkers differ between episodic migraine (EM) and chronic migraine (CM), but information on C-reactive protein (CRP) levels in EM and CM is conflicting. Thus, this study aimed to evaluate CRP levels in participants with EM and CM in comparison to those in healthy controls. MethodsPlasma CRP levels were evaluated by high-sensitivity CRP tests in female participants with EM (n = 174) and CM (n = 191) and healthy controls (n = 50). ResultsThe results showed no significant difference in CRP levels among the EM, CM, and control groups (median and interquartile range, 0.40 [0.15-0.70] mg/L vs. 0.40 [0.15-1.00] mg/L vs. 0.15 [0.15-0.90] mg/L, p = 0.991). The ratio of individuals with elevated CRP levels (>3.0 mg/L) did not significantly differ among the EM, CM, and control groups (3.4% [6/174] vs. 2.1% [4/191] vs. 0.0% [0/50], p = 0.876). Multivariable regression analyses revealed that CRP levels were not significantly associated with headache frequency per month (beta = -0.076, p = 0.238), the severity of anxiety (Generalized Anxiety Disorder-7 score, beta = 0.143, p = 0.886), and depression (Patient Health Questionnaire-9 score, beta = 0.143, p = 0.886). Further, CRP levels did not significantly differ according to clinical characteristics, fibromyalgia, medication overuse, preventive treatment, and classes of preventive treatment medications. Among participants with a body mass index >= 25 kg/m(2), the CRP levels in EM (n = 41) and CM (n = 17) were numerically higher than those in the control (n = 6) (1.30 [0.28-4.25] mg/L vs. 1.10 [0.50-3.15] mg/L vs. 0.40 [0.15-0.83] mg/L, p = 0.249) but did not reach statistical significance. ConclusionsThe interictal CRP level is not likely to be a biomarker for EM or CM.
C1 [Park, Chae Gyu] Ewha Womans Univ, Heart Immune Brain Network Res Ctr, Dept Life Sci, Seoul, South Korea.
   [Park, Chae Gyu] Yonsei Univ, Severance Biomed Sci Inst, Lab Immunol, Coll Med, Seoul, South Korea.
   [Park, Chae Gyu] Genuv Inc, Therapeut Antibody Res Ctr, Seoul, South Korea.
   [Lee, Sue Hyun; Chu, Min Kyung] Yonsei Univ, Dept Neurol, Coll Med, Seoul, South Korea.
C3 Ewha Womans University; Yonsei University; Yonsei University Health
   System; Yonsei University; Yonsei University Health System
RP Chu, MK (corresponding author), Yonsei Univ, Dept Neurol, Coll Med, Seoul, South Korea.
EM chumk@yonsei.ac.kr
OI Chu, Min Kyung/0000-0001-6221-1346; Park, Chae Gyu/0000-0003-1906-1308
FU Korea Health Technology R&D Project through the Korea Health Industry
   Development Institute (KHIDI) - Ministry of Health & Welfare, Republic
   of Korea;  [HVC22CO106]
FX Funding This research was supported by a grant from the Korea Health
   Technology R&D Project through the Korea Health Industry Development
   Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic
   of Korea (Grant No.: HVC22CO106).
CR Ablij Hans, 2002, Eur J Intern Med, V13, P412, DOI 10.1016/S0953-6205(02)00132-2
   Ahn JK, 2019, FRONT PSYCHIATRY, V10, DOI 10.3389/fpsyt.2019.00127
   Benatto MT, 2017, ARQ NEURO-PSIQUIAT, V75, P153, DOI 10.1590/0004-282X20170015
   Breslau N, 2003, NEUROLOGY, V60, P1308, DOI 10.1212/01.WNL.0000058907.41080.54
   Buse DC, 2013, HEADACHE, V53, P1278, DOI 10.1111/head.12150
   Chamberlain SR, 2019, BRIT J PSYCHIAT, V214, P11, DOI 10.1192/bjp.2018.66
   Copeland WE, 2012, PSYCHOL MED, V42, P2641, DOI 10.1017/S0033291712000554
   Ekinci O, 2017, NORD J PSYCHIAT, V71, P574, DOI 10.1080/08039488.2017.1363285
   Fava A, 2014, EUR J NEUROL, V21, P267, DOI 10.1111/ene.12289
   Ferreira KS, 2021, EXPERT REV NEUROTHER, V21, P817, DOI 10.1080/14737175.2021.1951236
   Gudmundsson LS, 2009, CEPHALALGIA, V29, P1301, DOI 10.1111/j.1468-2982.2009.01865.x
   Guldiken B, 2008, CAN J NEUROL SCI, V35, P448, DOI 10.1017/S0317167100009100
   Guldiken S, 2011, J HEADACHE PAIN, V12, P355, DOI 10.1007/s10194-011-0306-8
   Güzel I, 2013, NEUROL NEUROCHIR POL, V47, P357, DOI 10.5114/ninp.2013.36760
   Hamed SA, 2010, J STROKE CEREBROVASC, V19, P92, DOI 10.1016/j.jstrokecerebrovasdis.2009.04.007
   Kao TW, 2009, SAMJ S AFR MED J, V99, P326
   Khera A, 2005, J AM COLL CARDIOL, V46, P464, DOI 10.1016/j.jacc.2005.04.051
   Khera A, 2009, J CLIN ENDOCR METAB, V94, P3251, DOI 10.1210/jc.2008-2406
   Kling MA, 2007, BIOL PSYCHIAT, V62, P309, DOI 10.1016/j.biopsych.2006.09.033
   Kroenke K, 2002, PSYCHIAT ANN, V32, P509, DOI 10.3928/0048-5713-20020901-06
   Kroenke K, 2007, ANN INTERN MED, V146, P317, DOI 10.7326/0003-4819-146-5-200703060-00004
   Kurth T, 2008, CEPHALALGIA, V28, P49, DOI 10.1111/j.1468-2982.2007.01467.x
   Ladwig KH, 2003, BRAIN BEHAV IMMUN, V17, P268, DOI 10.1016/S0889-1591(03)00056-4
   Lipton RB, 2009, EXPERT REV NEUROTHER, V9, P1451, DOI [10.1586/ERN.09.93, 10.1002/pmic.200800454]
   Lopez-Candales Angel, 2017, J Nat Sci, V3
   Ma Y, 2011, CARDIOL RES PRACT, V2011, DOI 10.4061/2011/286509
   Meng Wei-guang, 2012, Zhongguo Zhen Jiu, V32, P519
   Nelson KB, 2010, ARCH PEDIAT ADOL MED, V164, P358, DOI 10.1001/archpediatrics.2010.17
   NISHIMOTO N, 1989, CLIN IMMUNOL IMMUNOP, V50, P399, DOI 10.1016/0090-1229(89)90147-5
   Olejnik S. F., 1984, Journal of Educational Statistics, V9, P129, DOI DOI 10.3102/10769986009002129
   Olesen J, 2018, CEPHALALGIA, V38, P1, DOI 10.1177/0333102417738202
   Park S, 2014, PSYCHOSOMATICS, V55, P640, DOI 10.1016/j.psym.2013.12.010
   Ridker PM, 2003, CIRCULATION, V107, P363, DOI 10.1161/01.CIR.0000053730.47739.3C
   Ridker PM, 2002, NEW ENGL J MED, V347, P1557, DOI 10.1056/NEJMoa021993
   Rockett FC, 2013, J HEADACHE PAIN, V14, DOI 10.1186/1129-2377-14-75
   Rose KM, 2004, NEUROLOGY, V63, P2233, DOI 10.1212/01.WNL.0000147289.50605.DC
   Schürks M, 2009, BMJ-BRIT MED J, V339, DOI 10.1136/bmj.b3914
   Shibata M, 2018, J AFFECT DISORDERS, V237, P73, DOI 10.1016/j.jad.2018.05.004
   Silva FA, 2007, HEADACHE, V47, P45, DOI 10.1111/j.1526-4610.2006.00532.x
   Song TJ, 2017, CEPHALALGIA, V37, P845, DOI 10.1177/0333102416653235
   Theodoropoulos DS, 2011, EUR REV MED PHARMACO, V15, P1117
   Tietjen GE, 2012, HEADACHE, V52, P920, DOI [10.1111/j.1526-4610.2012.02179.x, 10.1111/j.1526-4610.2012.02165.x]
   Tietjen GE, 2009, STROKE, V40, P2977, DOI 10.1161/STROKEAHA.109.547901
   Torzewski M, 2000, ARTERIOSCL THROM VAS, V20, P2094, DOI 10.1161/01.ATV.20.9.2094
   van Dongen RM, 2017, CEPHALALGIA, V37, P49, DOI 10.1177/0333102415625614
   Vanmolkot FH, 2007, CEPHALALGIA, V27, P843, DOI 10.1111/j.1468-2982.2007.01324.x
   Welch KMA, 2006, HEADACHE, V46, P197, DOI 10.1111/j.1526-4610.2006.00330.x
   Wener MH, 2000, J RHEUMATOL, V27, P2351
   Wilson AM, 2006, INT J CARDIOL, V106, P291, DOI 10.1016/j.ijcard.2005.01.068
   Wolfe F, 2016, SEMIN ARTHRITIS RHEU, V46, P319, DOI 10.1016/j.semarthrit.2016.08.012
   Yamamoto K, 2011, J PHYSIOL ANTHROPOL, V30, P15, DOI 10.2114/jpa2.30.15
   Yilmaz N, 2011, CLIN BIOCHEM, V44, P832, DOI 10.1016/j.clinbiochem.2011.04.015
   YOUNG B, 1991, PATHOLOGY, V23, P118, DOI 10.3109/00313029109060809
NR 53
TC 7
Z9 7
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD OCT 12
PY 2022
VL 13
AR 1021065
DI 10.3389/fneur.2022.1021065
PG 10
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 5U7AR
UT WOS:000876696100001
PM 36313504
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Masarone, M
   Rosato, V
   Dallio, M
   Gravina, AG
   Aglitti, A
   Loguercio, C
   Federico, A
   Persico, M
AF Masarone, Mario
   Rosato, Valerio
   Dallio, Marcello
   Gravina, Antonietta Gerarda
   Aglitti, Andrea
   Loguercio, Carmelina
   Federico, Alessandro
   Persico, Marcello
TI Role of Oxidative Stress in Pathophysiology of Nonalcoholic Fatty Liver
   Disease
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID ENDOPLASMIC-RETICULUM STRESS; NITRIC-OXIDE SYNTHASE; UNFOLDED PROTEIN
   RESPONSE; CYTOCHROME-P450 2E1; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   HEPATIC STEATOSIS; DNA-DAMAGE; LIPID-PEROXIDATION; HEME OXYGENASE-1
AB Liver steatosis without alcohol consumption, namely, nonalcoholic fatty liver disease (NAFLD), is a common hepatic condition that encompasses a wide spectrum of presentations, ranging from simple accumulation of triglycerides in the hepatocytes without any liver damage to inflammation, necrosis, ballooning, and fibrosis (namely, nonalcoholic steatohepatitis) up to severe liver disease and eventually cirrhosis and/or hepatocellular carcinoma. The pathophysiology of fatty liver and its progression is influenced by multiple factors (environmental and genetics), in a "multiple parallel-hit model," in which oxidative stress plays a very likely primary role as the starting point of the hepatic and extrahepatic damage. The aim of this review is to give a comprehensive insight on the present researches and findings on the role of oxidative stress mechanisms in the pathogenesis and pathophysiology of NAFLD. With this aim, we evaluated the available data in basic science and clinical studies in this field, reviewing the most recent works published on this topic.
C1 [Masarone, Mario; Rosato, Valerio; Gravina, Antonietta Gerarda; Aglitti, Andrea; Persico, Marcello] Univ Med Salerno, Internal Med & Hepatol Div, Dept Med, Salerno, Italy.
   [Dallio, Marcello; Loguercio, Carmelina; Federico, Alessandro] Univ Campania Luigi Vanvitelli, Hepatogastroenterol Div, Naples, Italy.
C3 Universita della Campania Vanvitelli
RP Masarone, M (corresponding author), Univ Med Salerno, Internal Med & Hepatol Div, Dept Med, Salerno, Italy.
EM mmasarone@unisa.it
RI Dallio, Marcello/ABG-7693-2020; Aglitti, Andrea/Y-1705-2019; persico,
   marcello/AAB-3562-2019; Gravina, Antonietta Gerarda/AAC-1528-2019;
   Federico, Alessandro/AAB-3893-2019; Rosato, Valerio/ABB-9874-2020;
   Masarone, Mario/H-8633-2017
OI DALLIO, MARCELLO/0000-0003-4153-815X; Masarone,
   Mario/0000-0003-0550-8201; Gravina, Antonietta
   Gerarda/0000-0001-8049-0115; Rosato, Valerio/0000-0002-3584-2414;
   Federico, Alessandro/0000-0002-0885-0793; Persico,
   Marcello/0000-0002-1399-6498; Aglitti, Andrea/0000-0001-9742-0172
CR Angulo P, 2002, NEW ENGL J MED, V346, P1221, DOI 10.1038/nrdp.2015.80
   [Anonymous], 2016, GASTROENTEROLOGY, DOI DOI 10.1053/j.gastro.2016.02.073
   Aubert J, 2011, CLIN RES HEPATOL GAS, V35, P630, DOI 10.1016/j.clinre.2011.04.015
   BACON BR, 1994, GASTROENTEROLOGY, V107, P1103, DOI 10.1016/0016-5085(94)90235-6
   Bedogni G, 2005, HEPATOLOGY, V42, P44, DOI 10.1002/hep.20734
   Begriche K, 2013, HEPATOLOGY, V58, P1497, DOI 10.1002/hep.26226
   Boursier J, 2016, HEPATOLOGY, V63, P764, DOI 10.1002/hep.28356
   Bril F, 2017, DIABETES CARE, V40, P419, DOI 10.2337/dc16-1787
   Brown KE, 2003, LIVER INT, V23, P232, DOI 10.1034/j.1600-0676.2003.00832.x
   Brunt EM, 2010, NAT REV GASTRO HEPAT, V7, P195, DOI 10.1038/nrgastro.2010.21
   Caballero F, 2010, J BIOL CHEM, V285, P18528, DOI 10.1074/jbc.M109.099333
   Caldwell SH, 1999, J HEPATOL, V31, P430, DOI 10.1016/S0168-8278(99)80033-6
   Carvalho MA, 2005, DIABETES, V54, P959, DOI 10.2337/diabetes.54.4.959
   Chalasani N, 2004, AM J GASTROENTEROL, V99, P1497, DOI 10.1111/j.1572-0241.2004.30159.x
   Chalasani N, 2003, HEPATOLOGY, V37, P544, DOI 10.1053/jhep.2003.50095
   Cornejo P, 2005, NITRIC OXIDE-BIOL CH, V13, P54, DOI 10.1016/j.niox.2005.04.009
   Couillard C, 2005, J CLIN ENDOCR METAB, V90, P6454, DOI 10.1210/jc.2004-2438
   Dallaire P, 2008, DIABETES, V57, P1999, DOI 10.2337/db08-0540
   Davidzon G, 2005, ANN NEUROL, V57, P921, DOI 10.1002/ana.20498
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   de Medeiros IC, 2015, MED HYPOTHESES, V85, P148, DOI 10.1016/j.mehy.2015.04.021
   DeMinicis S, 2014, HEPATOLOGY, V59, P1738, DOI 10.1002/hep.26695
   Deniaud A, 2008, ONCOGENE, V27, P285, DOI 10.1038/sj.onc.1210638
   Diehl AM, 2004, GUT, V53, P923, DOI 10.1136/gut.2003.037309
   Ding RB, 2017, INT J BIOL SCI, V13, P852, DOI 10.7150/ijbs.19370
   Donati G, 2004, GUT, V53, P1020, DOI 10.1136/gut.2003.027086
   Dongiovanni P, 2011, J HEPATOL, V55, P920, DOI 10.1016/j.jhep.2011.05.008
   Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI23621
   Elinav E, 2011, CELL, V145, P745, DOI 10.1016/j.cell.2011.04.022
   Ertle J, 2011, INT J CANCER, V128, P2436, DOI 10.1002/ijc.25797
   Federico A, 2017, MINERVA GASTROENTERO, V63, P385, DOI 10.23736/S1121-421X.17.02375-3
   Feldstein AE, 2006, AM J PHYSIOL-GASTR L, V290, pG1339, DOI 10.1152/ajpgi.00509.2005
   Fu SN, 2011, NATURE, V473, P528, DOI 10.1038/nature09968
   Fuchs CD, 2017, FEBS LETT, V591, P3360, DOI 10.1002/1873-3468.12845
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gao DQ, 2004, AM J PHYSIOL-GASTR L, V287, pG1070, DOI 10.1152/ajpgi.00228.2004
   Gariani K, 2016, HEPATOLOGY, V63, P1190, DOI 10.1002/hep.28245
   George DK, 1998, GASTROENTEROLOGY, V114, P311, DOI 10.1016/S0016-5085(98)70482-2
   Gholam PM, 2007, AM J GASTROENTEROL, V102, P399, DOI 10.1111/j.1572-0241.2006.01041.x
   Grattagliano I, 2008, J NUTR BIOCHEM, V19, P491, DOI 10.1016/j.jnutbio.2007.06.011
   Grattagliano I, 2012, CLIN BIOCHEM, V45, P610, DOI 10.1016/j.clinbiochem.2012.03.024
   Greene MW, 2010, J BIOL CHEM, V285, P42115, DOI 10.1074/jbc.M110.168575
   Guo HT, 2015, NAT MED, V21, P677, DOI 10.1038/nm.3893
   Hagström H, 2016, LIVER INT, V36, P1688, DOI 10.1111/liv.13144
   Henao-Mejia J, 2012, NATURE, V482, P179, DOI 10.1038/nature10809
   Hensley K, 2000, CARCINOGENESIS, V21, P983, DOI 10.1093/carcin/21.5.983
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Houtkooper RH, 2010, ENDOCR REV, V31, P194, DOI 10.1210/er.2009-0026
   Imeryuz N, 2007, J HEPATOL, V47, P851, DOI 10.1016/j.jhep.2007.06.018
   Inoue M, 2011, J CLIN BIOCHEM NUTR, V48, P161, DOI 10.3164/jcbn.09-122GFR
   Irene P, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-11744-6
   Iwakiri Y, 2008, HEPATOLOGY, V47, P1754, DOI 10.1002/hep.22203
   Jandhyala SM, 2015, WORLD J GASTROENTERO, V21, P8787, DOI 10.3748/wjg.v21.i29.8787
   Gonzalez-Paredes FJ, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0156650
   Pirola CJ, 2013, GUT, V62, P1356, DOI 10.1136/gutjnl-2012-302962
   Kang S, 2016, J BIOL CHEM, V291, P5185, DOI 10.1074/jbc.M115.705012
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Kendrick AA, 2011, BIOCHEM J, V433, P505, DOI 10.1042/BJ20100791
   Kushnareva Y, 2002, BIOCHEM J, V368, P545, DOI 10.1042/BJ20021121
   Lai SJ, 2017, BIOSCIENCE REP, V37, DOI 10.1042/BSR20170869
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Langer DA, 2008, HEPATOLOGY, V47, P1983, DOI 10.1002/hep.22285
   Leamy AK, 2014, J LIPID RES, V55, P1478, DOI 10.1194/jlr.M050237
   Leung C, 2016, NAT REV GASTRO HEPAT, V13, P412, DOI 10.1038/nrgastro.2016.85
   Li M, 2015, INT J BIOL SCI, V11, P1458, DOI [10.7150/ijbs.13444, 10.7150/ijbs.10809]
   Maeda H, 2016, FREE RADICAL RES, V50, P720, DOI 10.3109/10715762.2016.1170125
   Malaguarnera L, 2005, J HEPATOL, V42, P585, DOI 10.1016/j.jhep.2004.11.040
   Malhotra JD, 2007, SEMIN CELL DEV BIOL, V18, P716, DOI 10.1016/j.semcdb.2007.09.003
   Marra F, 2018, J HEPATOL, V68, P280, DOI 10.1016/j.jhep.2017.11.014
   Masarone M, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0178473
   Masarone M, 2014, REV RECENT CLIN TRIA, V9, P126, DOI 10.2174/1574887109666141216111143
   Matteoni CA, 1999, GASTROENTEROLOGY, V116, P1413, DOI 10.1016/S0016-5085(99)70506-8
   Minamiyama Y, 2010, AM J PHYSIOL-ENDOC M, V298, pE1140, DOI 10.1152/ajpendo.00620.2009
   Mridha AR, 2017, J HEPATOL, V66, P1037, DOI 10.1016/j.jhep.2017.01.022
   Nascimbeni F, 2013, J HEPATOL, V59, P859, DOI 10.1016/j.jhep.2013.05.044
   Nelson JE, 2012, HEPATOLOGY, V56, P1730, DOI 10.1002/hep.25856
   Nobili V, 2014, J PEDIATR GASTR NUTR, V58, P632, DOI 10.1097/MPG.0000000000000279
   Okada K, 2013, J GASTROENTEROL, V48, P620, DOI 10.1007/s00535-012-0659-z
   Otogawa K, 2007, AM J PATHOL, V170, P967, DOI 10.2353/ajpath.2007.060441
   Palmieri VO, 2006, J NUTR, V136, P3022, DOI 10.1093/jn/136.12.3022
   Pasarín M, 2017, WORLD J GASTROENTERO, V23, P6777, DOI 10.3748/wjg.v23.i37.6777
   Pasarín M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0032785
   Patterson RE, 2016, AM J PHYSIOL-ENDOC M, V310, pE484, DOI 10.1152/ajpendo.00492.2015
   Perreault M, 2001, NAT MED, V7, P1138, DOI 10.1038/nm1001-1138
   Persico M, 2017, BMC GASTROENTEROL, V17, DOI 10.1186/s12876-017-0592-y
   Peterson LW, 2014, NAT REV IMMUNOL, V14, P141, DOI 10.1038/nri3608
   Petta S, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17122082
   Podrini C, 2013, CURR PHARM DESIGN, V19, P2737, DOI 10.2174/1381612811319150009
   Potenza MA, 2005, AM J PHYSIOL-HEART C, V289, pH813, DOI 10.1152/ajpheart.00092.2005
   Rahman K, 2016, GASTROENTEROLOGY, V151, P733, DOI 10.1053/j.gastro.2016.06.022
   Rahman K, 2016, LAB INVEST, V96, P895, DOI 10.1038/labinvest.2016.61
   Ricchi M, 2009, J GASTROEN HEPATOL, V24, P830, DOI 10.1111/j.1440-1746.2008.05733.x
   Rinella Mary E, 2011, Hepatology, V54, P1600, DOI 10.1002/hep.24553
   Sabbagha NGA, 2011, PEDIATR RES, V70, P31, DOI 10.1203/PDR.0b013e31821b89ee
   Schattenberg JM, 2006, HEPATOLOGY, V43, P163, DOI 10.1002/hep.20999
   Seki S, 2002, J HEPATOL, V37, P56, DOI 10.1016/S0168-8278(02)00073-9
   Shimizu Y, 2009, ANTIOXID REDOX SIGN, V11, P2317, DOI [10.1089/ars.2009.2501, 10.1089/ARS.2009.2501]
   Silva MFB, 2008, J INHERIT METAB DIS, V31, P205, DOI 10.1007/s10545-008-0841-x
   Song BB, 2008, J CLIN INVEST, V118, P3378, DOI 10.1172/JCI34587
   Stiuso P, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/169216
   SUTHANTHIRAN M, 1990, P NATL ACAD SCI USA, V87, P3343, DOI 10.1073/pnas.87.9.3343
   Tilg H, 2010, HEPATOLOGY, V52, P1836, DOI 10.1002/hep.24001
   Valenti L, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048804
   van Galen P, 2014, NATURE, V510, P268, DOI 10.1038/nature13228
   Varela NM, 2008, BIOL RES, V41, P81, DOI /S0716-97602008000100010
   Vos B, 2011, ACTA GASTRO-ENT BELG, V74, P389
   Wang D, 2006, ENDOCRINOLOGY, V147, P943, DOI 10.1210/en.2005-0570
   Wei YR, 2006, AM J PHYSIOL-ENDOC M, V291, pE275, DOI 10.1152/ajpendo.00644.2005
   Wei YR, 2009, MOL CELL BIOCHEM, V331, P31, DOI 10.1007/s11010-009-0142-1
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Weltman MD, 1996, GASTROENTEROLOGY, V111, P1645, DOI 10.1016/S0016-5085(96)70028-8
   Woodhouse CA, 2018, ALIMENT PHARM THER, V47, P192, DOI 10.1111/apt.14397
   Yamaguchi K, 2007, HEPATOLOGY, V45, P1366, DOI 10.1002/hep.21655
   Yokota S, 2001, J HISTOCHEM CYTOCHEM, V49, P613, DOI 10.1177/002215540104900508
   Yoon Y, 2000, CLIN CHEM, V46, P1626
   Zaki MH, 2010, IMMUNITY, V32, P379, DOI 10.1016/j.immuni.2010.03.003
   Zamparelli MS, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17081225
NR 117
TC 506
Z9 525
U1 6
U2 95
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2018
VL 2018
AR 9547613
DI 10.1155/2018/9547613
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA GK6BJ
UT WOS:000436265900001
PM 29991976
OA hybrid, Green Published, Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Alshehri, T
   Mook-Kanamori, DO
   de Mutsert, R
   Penninx, BWJH
   Rosendaal, FR
   le Cessie, S
   Milaneschi, Y
AF Alshehri, Tahani
   Mook-Kanamori, Dennis O.
   de Mutsert, Renee
   Penninx, Brenda W. J. H.
   Rosendaal, Frits R.
   le Cessie, Saskia
   Milaneschi, Yuri
TI The association between adiposity and atypical energy-related symptoms
   of depression: A role for metabolic dysregulations
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Genetic risk score; Depression; Metabolic Syndrome; Body Fat
   Distribution; Body Mass Index; Homeostasis
ID BODY-MASS INDEX; MAJOR DEPRESSION; OBESITY; FEATURES
AB Background: Adiposity has been shown to be linked with atypical energy-related symptoms (AES) of depression. We used genomics to separate the effect of adiposity from that of metabolic dysregulations to examine whether the link between obesity and AES is dependent on the presence of metabolic dysregulations. Method: Data were from NEO (n = 5734 individuals) and NESDA (n = 2238 individuals) cohorts, in which the Inventory of Depressive Symptomatology (IDS-SR30) was assessed. AES profile was based on four symptoms: increased appetite, increased weight, low energy level, and leaden paralysis. We estimated associations between AES and two genetic risk scores (GRS) indexing increasing total body fat with (metabolically unhealthy adiposity, GRS-MUA) and without (metabolically healthy adiposity, GRS-MHA) metabolic dysregulations.Results: We validated that both GRS-MUA and GRS-MHA were associated with higher total body fat in NEO study, but divergently associated with biomarkers of metabolic health (e.g., fasting glucose and HDL-cholesterol) in both cohorts. In the pooled results, per standard deviation, GRS-MUA was specifically associated with a higher AES score (beta = 0.03, 95%CI: 0.01; 0.05), while there was no association between GRS-MHA and AES (beta =-0.01, 95%CI:-0.03; 0.01).Conclusion: These results suggest that the established link between adiposity and AES profile emerges in the presence of metabolic dysregulations, which may represent the connecting substrate between the two conditions.
C1 [Alshehri, Tahani; Mook-Kanamori, Dennis O.; de Mutsert, Renee; Rosendaal, Frits R.; le Cessie, Saskia] Leiden Univ, Dept Clin Epidemiol, Med Ctr, Leiden, Netherlands.
   [Mook-Kanamori, Dennis O.] Leiden Univ, Dept Publ Hlth & Primary Care, Med Ctr, Leiden, Netherlands.
   [Penninx, Brenda W. J. H.; Milaneschi, Yuri] Vrije Univ, Amsterdam Publ Hlth Res Inst, Dept Psychiat, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands.
   [le Cessie, Saskia] Leiden Univ, Dept Biomed Data Sci, Med Ctr, Leiden, Netherlands.
   [Alshehri, Tahani] Leiden Univ Med Ctr LUMC, Albinusdreef 2,Postzone C7-P,Postbus 9600, NL-2300 RC Leiden, Netherlands.
C3 Leiden University - Excl LUMC; Leiden University; Leiden University
   Medical Center (LUMC); Leiden University - Excl LUMC; Leiden University;
   Leiden University Medical Center (LUMC); University of Amsterdam; Vrije
   Universiteit Amsterdam; Leiden University - Excl LUMC; Leiden
   University; Leiden University Medical Center (LUMC); Leiden University;
   Leiden University Medical Center (LUMC)
RP Alshehri, T (corresponding author), Leiden Univ Med Ctr LUMC, Albinusdreef 2,Postzone C7-P,Postbus 9600, NL-2300 RC Leiden, Netherlands.
EM t.m.alshehri@lumc.nl
RI Penninx, Brenda/S-7627-2017; Rosendaal, Frits/Q-3842-2017; le+Cessie,
   Saskia/HGC-8966-2022; Alshehri, Tahani/IUP-1119-2023
OI Milaneschi, Yuri/0000-0002-3697-6617
FU Geestkracht program of the Netherlands Organization for Health Research
   and Development (ZonMw) [10-000-1002]; VU University Medical Center; GGZ
   in Geest; Leiden University Medical Center; Leiden University; GGZ
   Rivierduinen; University Medical Center Groningen; University of
   Groningen; Lentis; GGZ Friesland; GGZ Drenthe; Rob Giel
   Onderzoekscentrum; Leiden University, Research Profile Area Vascular and
   Regenerative Medicine; Dutch Science Organization (ZonMW-VENI Grant)
   [916.14.023]
FX Acknowledgments NESDA The infrastructure for the NESDA study (
   www.nesda.nl) is funded through the Geestkracht program of the
   Netherlands Organization for Health Research and Development (ZonMw,
   grant number: 10-000-1002) and financial contributions by participating
   universities and mental health care organizations (VU University Medical
   Center, GGZ in Geest, Leiden University Medical Center, Leiden
   University, GGZ Rivierduinen, University Medical Center Groningen,
   University of Groningen, Lentis, GGZ Friesland, GGZ Drenthe, Rob Giel
   Onderzoekscentrum) . NEO study The NEO study is supported by the
   participating Departments, Division, and Board of Directors of the
   Leiden University Medical Center, and by the Leiden University, Research
   Profile Area Vascular and Regenerative Medicine. DOM-K is supported by
   Dutch Science Organization (ZonMW-VENI Grant No. 916.14.023) . We
   express our gratitude to all participants of the Netherlands
   Epidemiology of Obesity (NEO) study, in addition to all participating
   general practi-tioners. We furthermore thank P.R. van Beelen and all
   research nurses for collecting the data, P.J. Noordijk and her team for
   sample handling and storage, and I. de Jonge for data management of the
   NEO study. Finally, we would like to express our gratitude to Dr R.
   Noordam for extracting the genetics data in this study and answering our
   related questions.
CR Alshehri T, 2019, PSYCHONEUROENDOCRINO, V110, DOI 10.1016/j.psyneuen.2019.104429
   Badini I, 2022, PSYCHOL MED, V52, P726, DOI 10.1017/S0033291720002342
   Blaine B, 2008, J HEALTH PSYCHOL, V13, P1190, DOI 10.1177/1359105308095977
   Blauw LL, 2018, CIRC-GENOM PRECIS ME, V11, DOI 10.1161/CIRCGEN.117.002034
   Brewis AA, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15050891
   Brydges CR, 2022, BRAIN BEHAV IMMUN, V102, P42, DOI 10.1016/j.bbi.2022.02.003
   de Mutsert R, 2013, EUR J EPIDEMIOL, V28, P513, DOI 10.1007/s10654-013-9801-3
   Delgado I, 2018, PSYCHONEUROENDOCRINO, V91, P55, DOI 10.1016/j.psyneuen.2018.02.030
   Gómez-Zorita S, 2021, J PHYSIOL BIOCHEM, V77, P175, DOI 10.1007/s13105-020-00781-x
   Ji YJ, 2019, DIABETES, V68, P207, DOI 10.2337/db18-0708
   Jokela M, 2014, MOL PSYCHIATR, V19, P910, DOI 10.1038/mp.2013.162
   Khan Ahsan Y, 2006, Ann Clin Psychiatry, V18, P91, DOI 10.1080/10401230600614496
   Khandaker GM, 2020, MOL PSYCHIATR, V25, P1477, DOI 10.1038/s41380-019-0395-3
   Lamers F, 2020, BRAIN BEHAV IMMUN, V88, P174, DOI 10.1016/j.bbi.2020.04.002
   Locke AE, 2015, NATURE, V518, P197, DOI 10.1038/nature14177
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Mannan M, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0157240
   Mannan M, 2016, ASIAN J PSYCHIATR, V21, P51, DOI 10.1016/j.ajp.2015.12.008
   Martin S, 2022, ELIFE, V11, DOI [10.7554/eLife.72452, 10.7554/eLife.72452.sa0, 10.7554/eLife.72452.sa1, 10.7554/eLife.72452.sa2]
   Mbarek H, 2017, TWIN RES HUM GENET, V20, P267, DOI 10.1017/thg.2017.30
   Milaneschi Y, 2016, MOL PSYCHIATR, V21, P516, DOI 10.1038/mp.2015.86
   Milaneschi Y, 2021, BRAIN BEHAV IMMUN, V97, P167, DOI 10.1016/j.bbi.2021.07.007
   Milaneschi Y, 2021, MOL PSYCHIATR, V26, P7393, DOI 10.1038/s41380-021-01188-w
   Milaneschi Y, 2020, BIOL PSYCHIAT, V88, P369, DOI 10.1016/j.biopsych.2020.01.014
   Milaneschi Y, 2019, MOL PSYCHIATR, V24, P18, DOI 10.1038/s41380-018-0017-5
   Milaneschi Y, 2017, JAMA PSYCHIAT, V74, P1214, DOI 10.1001/jamapsychiatry.2017.3016
   Milaneschi Y, 2017, BIOL PSYCHIAT, V81, P807, DOI 10.1016/j.biopsych.2015.10.023
   Mulugeta A, 2019, DEPRESS ANXIETY, V36, P1154, DOI 10.1002/da.22963
   Paans NPG, 2018, J PSYCHIATR RES, V103, P18, DOI 10.1016/j.jpsychires.2018.05.003
   Penninx BWJH, 2008, INT J METH PSYCH RES, V17, P121, DOI 10.1002/mpr.256
   Primeau V, 2011, INT J OBESITY, V35, P971, DOI 10.1038/ijo.2010.216
   Rush AJ, 1996, PSYCHOL MED, V26, P477, DOI 10.1017/S0033291700035558
   Tyrrell J, 2019, INT J EPIDEMIOL, V48, P834, DOI 10.1093/ije/dyy223
NR 33
TC 2
Z9 2
U1 0
U2 6
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD FEB
PY 2023
VL 108
BP 197
EP 203
DI 10.1016/j.bbi.2022.12.005
EA DEC 2022
PG 7
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA 7K2QD
UT WOS:000905129500001
PM 36494049
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Ertas, F
   Kaya, H
   Acet, H
   Çil, H
   Akyüz, A
   Islamoglu, Y
   Tekbas, E
   Aritürk, Z
   Aydin, M
   Soydinç, S
AF Ertas, Faruk
   Kaya, Hasan
   Acet, Halit
   Cil, Habib
   Akyuz, Abdurrahman
   Islamoglu, Yahya
   Tekbas, Ebru
   Ariturk, Zuhal
   Aydin, Mesut
   Soydinc, Serdar
TI Increased echocardiographic epicardial fat thickness is related to
   impaired diurnal blood pressure profiles
SO BLOOD PRESSURE
LA English
DT Article
DE Dipper; echocardiography; epicardial fat thickness; hypertension;
   non-dipper
ID ADIPOSE-TISSUE; INSULIN-RESISTANCE; OXIDATIVE STRESS; ORGAN DAMAGE;
   HYPERTENSION; INFLAMMATION; PATTERNS; DECREASE; VOLUMES
AB Objective. Epicardial fat has been proposed as a new cardiometabolic risk factor. Although epicardial fat thickness (EFT) is associated with hypertension, the relationship between diurnal blood pressure profiles and EFT is still unknown. The purpose of this study is to investigate the association between the echocardiographic EFT and diurnal blood pressure profiles in hypertensive patients. Methods. After the ambulatory blood pressures of 123 patients were monitored, they were divided into three groups according to the clinical diagnoses: 41 patients (33.3%) were in the normotensive group, 40 patients (32.5%) were in the dipper hypertensive group and 42 patients (34.1%) were in the non-dipper hypertensive group. All participants underwent transthoracic echocardiography and ambulatory blood pressure monitoring to measure the EFT and blood pressure responses. Results. The mean EFT measurements of the dipper group were significantly higher than the normotensive group (6.5 +/- 0.6 vs 5.8 +/- 0.6; p < 0.0001). On the other hand, the mean EFTs of the non-dipper group were also significantly higher than the dipper group (7.4 +/- 0.7 vs 6.5 +/- 0.6, p < 0.0001). An EFT of >= 7 mm predicted the non-dipper profile in hypertensive patients with 74% sensitivity and 71% specificity (receiving operator characteristic area under the curve: 0.826, 95% CI 0.738-0.913; p < 0.0001). EFT was associated with both dipper (OR 8.9, 95% CI 3.03-26.3; p < 0.0001) and non-dipper blood pressure profiles (OR 12.3, 95% CI 1.75-86.31; p < 0.0001), and this relationship was also independent from all the risk factors. Conclusion. Echocardiographic EFT assessment is independently associated with impaired diurnal blood pressure profiles in the hypertensive individuals. Thus, the echocardiographic assessment of the EFT may be helpful in cardiometabolic risk stratification and therapeutic interventions.
C1 [Ertas, Faruk; Kaya, Hasan; Cil, Habib; Akyuz, Abdurrahman; Islamoglu, Yahya; Tekbas, Ebru; Ariturk, Zuhal; Aydin, Mesut; Soydinc, Serdar] Dicle Univ, Dept Cardiol, Fac Med, Diyarbakir, Turkey.
   [Acet, Halit] Diyarbakir Educ & Res Hosp, Dept Cardiol, Diyarbakir, Turkey.
C3 Dicle University; Diyarbakir Training & Research Hospital
RP Ertas, F (corresponding author), Dicle Univ, Dept Cardiol, Fac Med, Diyarbakir, Turkey.
EM farukertas@hotmail.com
RI Ertas, Faruk/N-6409-2013; akyüz, abdurrahman/IZQ-0738-2023; KAYA,
   HASAN/F-8496-2013
OI KAYA, HASAN/0000-0003-3923-4026
CR Cuspidi C, 2008, BLOOD PRESS MONIT, V13, P318, DOI 10.1097/MBP.0b013e32830d4bf8
   de la Sierra A, 2009, HYPERTENSION, V53, P466, DOI 10.1161/HYPERTENSIONAHA.108.124008
   DEVEREUX RB, 1987, HYPERTENSION, V9, P19
   Djaberi R, 2008, AM J CARDIOL, V102, P1602, DOI 10.1016/j.amjcard.2008.08.010
   Gastaldelli A, 2010, NUTR METAB CARDIOVAS, V20, P481, DOI 10.1016/j.numecd.2010.05.005
   Grandi AM, 2002, AM J CARDIOL, V89, P1193, DOI 10.1016/S0002-9149(02)02303-2
   HENRY WL, 1980, CIRCULATION, V62, P212, DOI 10.1161/01.CIR.62.2.212
   Hoshide S, 2003, AM J HYPERTENS, V16, P434, DOI 10.1016/S0895-7061(03)00567-3
   Iacobellis G, 2005, NAT CLIN PRACT CARD, V2, P536, DOI 10.1038/ncpcardio0319
   Iacobellis G, 2004, AM J CARDIOL, V94, P1084, DOI 10.1016/j.amjcard.2004.06.075
   Iacobellis G, 2003, J CLIN ENDOCR METAB, V88, P5163, DOI 10.1210/jc.2003-030698
   Iacobellis G, 2003, OBES RES, V11, P304, DOI 10.1038/oby.2003.45
   Iacobellis G, 2008, OBESITY, V16, P887, DOI 10.1038/oby.2008.6
   Iacobellis G, 2006, OBESITY, V14, P1679, DOI 10.1038/oby.2006.192
   Ihm SH, 2011, KOREAN CIRC J, V41, P175, DOI 10.4070/kcj.2011.41.4.175
   Kotsis V, 2005, HYPERTENSION, V45, P602, DOI 10.1161/01.HYP.0000158261.86674.8e
   Lacobellis G, 2008, HORM METAB RES, V40, P442, DOI 10.1055/s-2008-1062724
   Mansoor GA, 2002, J HUM HYPERTENS, V16, P237, DOI 10.1038/sj.jhh.1001383
   Manzella D, 2001, J CLIN ENDOCR METAB, V86, P2769, DOI 10.1210/jc.86.6.2769
   Mazurek T, 2003, CIRCULATION, V108, P2460, DOI 10.1161/01.CIR.0000099542.57313.C5
   Parati G, 2000, J HYPERTENS, V18, P1725, DOI 10.1097/00004872-200018120-00004
   Pi-Sunyer FX, 1998, OBES RES, V6, p51S
   Pou KM, 2007, CIRCULATION, V116, P1234, DOI 10.1161/CIRCULATIONAHA.107.710509
   Profant J, 1999, HYPERTENSION, V33, P1099, DOI 10.1161/01.HYP.33.5.1099
   Rizzo V, 2000, AM HEART J, V139, P529
   Rosito GA, 2008, CIRCULATION, V117, P605, DOI 10.1161/CIRCULATIONAHA.107.743062
   Sengul C, 2011, BLOOD PRESSURE, V20, P303, DOI 10.3109/08037051.2011.569992
   Silaghi AC, 2011, MED ULTRASON, V13, P15
   Sironi AM, 2004, HYPERTENSION, V44, P127, DOI 10.1161/01.HYP.0000137982.10191.0a
   Sironi AM, 2008, HYPERTENSION, V51, P282, DOI 10.1161/HYPERTENSIONAHA.107.098640
   Teijeira-Fernandez E, 2008, J HUM HYPERTENS, V22, P856, DOI 10.1038/jhh.2008.75
   Zhang LF, 2003, CIRCULATION, V108, P472, DOI 10.1161/01.CIR.0000080378.96063.23
NR 32
TC 20
Z9 22
U1 0
U2 13
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
EI 1651-1999
J9 BLOOD PRESSURE
JI Blood Pressure
PD JUN
PY 2012
VL 21
IS 3
BP 202
EP 208
DI 10.3109/08037051.2011.649538
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 939RO
UT WOS:000303831700010
PM 22229446
DA 2025-06-11
ER

PT J
AU Cai, XJ
   Li, X
   Li, L
   Huang, XZ
   Liu, YS
   Chen, L
   Zhang, K
   Wang, L
   Li, XN
   Song, JT
   Li, SZ
   Zhang, Y
   Zhang, M
AF Cai, Xiaojun
   Li, Xuan
   Li, Li
   Huang, Xiao-Zhen
   Liu, Yu-Sheng
   Chen, Liang
   Zhang, Ke
   Wang, Lin
   Li, Xiaonan
   Song, Jiantao
   Li, Shuzhen
   Zhang, Yun
   Zhang, Mei
TI Adiponectin reduces carotid atherosclerotic plaque formation in
   ApoE<SUP>-/-</SUP> mice: Roles of oxidative and nitrosative stress and
   inducible nitric oxide synthase
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE adiponectin; atherosclerosis; oxidative stress; nitrite/nitrate;
   inducible nitric oxide synthase
ID IMPROVES ENDOTHELIAL FUNCTION; ADIPOSE-SPECIFIC PROTEIN; TYPE-2 DIABETIC
   MICE; OXIDATIVE/NITRATIVE STRESS; HYPERLIPIDEMIC RATS; ADHESION
   MOLECULES; INSULIN-RESISTANCE; METABOLIC SYNDROME; SIGNALING PATHWAY;
   CORONARY-ARTERY
AB Adiponectin (APN) is an important anti-atherogenic adipocytokine. The aim of the present study was to investigate the role of adiponectin in atherosclerotic plaque formation and clarify its mechanisms. An atherosclerosis model was induced by in vivo perivascular constrictive silica collar placement on the left common carotid arteries in male apolipoprotein E-deficient (ApoE(-/-)) mice. All of the mice were fed a high-fat diet, and divided into phosphate-buffered saline, adenovirus (Ad)-beta-galactosidase and Ad-APN treatment groups. Compared with treatment of Ad-beta-gal or PBS, Ad-APN treatment markedly reduced inducible nitric oxide synthase (iNOS) protein expression, decreased in nitric oxide/superoxide production, blocked peroxynitrite formation and reversed the progression of atherosclerotic lesions. Adiponectin may be a natural molecule that reduces atherosclerosis by inhibiting iNOS and consequently diminishing oxidative/nitrative stress.
C1 [Cai, Xiaojun; Li, Xuan; Li, Li; Huang, Xiao-Zhen; Liu, Yu-Sheng; Chen, Liang; Zhang, Ke; Wang, Lin; Li, Xiaonan; Song, Jiantao; Zhang, Yun; Zhang, Mei] Shandong Univ, Qilu Hosp, Chinese Minist Educ, Key Lab Cardiovasc Remodeling & Funct Res, Jinan 250012, Shandong, Peoples R China.
   [Cai, Xiaojun; Li, Xuan; Li, Li; Huang, Xiao-Zhen; Liu, Yu-Sheng; Chen, Liang; Zhang, Ke; Wang, Lin; Li, Xiaonan; Song, Jiantao; Zhang, Yun; Zhang, Mei] Shandong Univ, Qilu Hosp, Chinese Minist Publ Hlth, Jinan 250012, Shandong, Peoples R China.
   [Cai, Xiaojun; Li, Li; Li, Shuzhen] Shandong Univ, Dept Cardiol, Jinan Cent Hosp, Jinan 250014, Shandong, Peoples R China.
   [Li, Xuan] Weifang Tradit Chinese Med Hosp, Dept Cardiol, Weifang 261041, Shandong, Peoples R China.
   [Huang, Xiao-Zhen] Jinan Huaiyin Hosp, Dept Cardiol, Jinan 250021, Shandong, Peoples R China.
   [Liu, Yu-Sheng] Shandong Univ, Hosp 2, Dept Cardiol, Jinan 250033, Shandong, Peoples R China.
C3 Ministry of Education - China; Shandong University; Shandong University;
   Shandong University; Shandong First Medical University & Shandong
   Academy of Medical Sciences; Shandong University
RP Zhang, M (corresponding author), Shandong Univ, Qilu Hosp, Chinese Minist Educ, Key Lab Cardiovasc Remodeling & Funct Res, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China.
EM daixh@vip.sina.com
RI Cai, Xiaojun/C-1864-2015; Li, Linlin/M-8350-2014
FU National Basic Research Program of China (973 Program) [2011CB503906];
   Development Program of China (863 Program) [2007AA02Z448]; National
   Natural Science Foundation of China [30728025, 30970709]; National
   Natural Science Funds for Young Scholar [81200211]; Shandong Young
   Scientists Award Fund [BS2012SW003]; Scientific and technology
   Development program of Jinan [201003125, 200905035]
FX This study was supported by The National Basic Research Program of China
   (973 Program, 2011CB503906), Development Program of China (863 Program,
   2007AA02Z448), the National Natural Science Foundation of China (nos.
   30728025 and 30970709), National Natural Science Funds for Young Scholar
   (no. 81200211), grants from the Shandong Young Scientists Award Fund
   (no. BS2012SW003) and grants from Scientific and technology Development
   program of Jinan (nos. 201003125 and 200905035).
CR Arita Y, 1999, BIOCHEM BIOPH RES CO, V257, P79, DOI 10.1006/bbrc.1999.0255
   Beckman JS, 1996, AM J PHYSIOL-CELL PH, V271, pC1424
   Cai XJ, 2010, MOL ENDOCRINOL, V24, P218, DOI 10.1210/me.2009-0128
   Essick EE, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0068697
   Fernández-Real JM, 2004, DIABETES CARE, V27, P739, DOI 10.2337/diacare.27.3.739
   Fisman EZ, 2014, CARDIOVASC DIABETOL, V13, DOI 10.1186/1475-2840-13-103
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gozin A, 1998, FREE RADICAL BIO MED, V25, P1021, DOI 10.1016/S0891-5849(98)00134-8
   Hotta K, 2000, ARTERIOSCL THROM VAS, V20, P1595, DOI 10.1161/01.ATV.20.6.1595
   HUIE RE, 1993, FREE RADICAL RES COM, V18, P195, DOI 10.3109/10715769309145868
   Lautamaki R, 2007, METABOLISM, V56, P881, DOI 10.1016/j.metabol.2007.01
   Lee S, 2012, AM J PHYSIOL-HEART C, V303, pH106, DOI 10.1152/ajpheart.00110.2012
   Lee S, 2011, AM J PHYSIOL-HEART C, V301, pH306, DOI 10.1152/ajpheart.01306.2010
   Li L, 2010, CIRC J, V74, P552, DOI 10.1253/circj.CJ-09-0304
   Li R, 2007, AM J PHYSIOL-ENDOC M, V293, pE1703, DOI 10.1152/ajpendo.00462.2007
   Li R, 2010, J MOL CELL CARDIOL, V49, P508, DOI 10.1016/j.yjmcc.2010.03.002
   Margaritis M, 2013, CIRCULATION, V127, P2209, DOI 10.1161/CIRCULATIONAHA.112.001133
   Motoshima H, 2004, BIOCHEM BIOPH RES CO, V315, P264, DOI 10.1016/j.bbrc.2004.01.049
   Muscoli C, 2003, BRIT J PHARMACOL, V140, P445, DOI 10.1038/sj.bjp.0705430
   Okamoto Y, 2002, CIRCULATION, V106, P2767, DOI 10.1161/01.CIR.0000042707.50032.19
   Okamoto Y, 2000, HORM METAB RES, V32, P47, DOI 10.1055/s-2007-978586
   Okui H, 2008, INT J CARDIOL, V126, P53, DOI 10.1016/j.ijcard.2007.03.116
   Ouchi N, 2003, HYPERTENSION, V42, P231, DOI 10.1161/01.HYP.0000083488.67550.B8
   Ouchi N, 1999, CIRCULATION, V100, P2473, DOI 10.1161/01.CIR.100.25.2473
   Ouedraogo R, 2006, DIABETES, V55, P1840, DOI 10.2337/db05-1174
   Rabe K, 2008, MOL MED, V14, P741, DOI 10.2119/2008-00058.Rabe
   Shimabukuro M, 2003, J CLIN ENDOCR METAB, V88, P3236, DOI 10.1210/jc.2002-021883
   Sulistyoningrum DC, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-170
   Tan KCB, 2004, J CLIN ENDOCR METAB, V89, P765, DOI 10.1210/jc.2003-031012
   Tao L, 2003, CIRCULATION, V108, P2805, DOI 10.1161/01.CIR.0000097003.49585.5E
   Tao L, 2007, CIRCULATION, V115, P1408, DOI 10.1161/CIRCULATIONAHA.106.666941
   Wang XM, 2014, MED SCI MONITOR, V20, P1792, DOI 10.12659/MSM.892299
   Zhao ZQ, 2003, AM J PHYSIOL-HEART C, V285, pH579, DOI 10.1152/ajpheart.01064.2002
   Zheng QJ, 2011, ARTERIOSCL THROM VAS, V31, P2616, DOI 10.1161/ATVBAHA.111.231050
   Zoccali C, 2002, J AM SOC NEPHROL, V13, P134, DOI 10.1681/ASN.V131134
NR 35
TC 27
Z9 34
U1 0
U2 23
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD MAR
PY 2015
VL 11
IS 3
BP 1715
EP 1721
DI 10.3892/mmr.2014.2947
PG 7
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA CD2OA
UT WOS:000350917700022
PM 25395016
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Bhat, PV
   Vinod, V
   Priyanka, AN
   Kamath, A
AF Bhat, Parvati, V
   Vinod, Vinutha
   Priyanka, Alluri Naga
   Kamath, Asha
TI Maternal serum lipid levels, oxidative stress and antioxidant activity
   in pre-eclampsia patients from Southwest India
SO PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR
   HEALTH
LA English
DT Article
DE Fasting glucose; Fasting insulin; Insulin resistance; Oxidative stress;
   Pre-eclampsia
ID DIABETES-MELLITUS; PREGNANCY; COMPLICATIONS; DISORDERS
AB Objective: A study was carried out to evaluate the effects of metabolic syndrome components and oxidative stress factors among preeclamptic women from South West India.
   Study design: A case-control study was carried out by enrolling fifty pre-eclampsia cases and hundred low-risk pregnant women within the age group of 18-40 years, at 28-34 weeks of pregnancy. The fasting glucose level, fasting insulin level, insulin resistance, total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), malondialdehyde, the ferric reducing ability of plasma (FRAP assay), cardiac output and aortic wall distensibility were measured.
   Main outcome measures: There was a significant rise in the fasting blood glucose, fasting insulin, insulin resistance levels, total cholesterol, triglycerides, LDL, and antioxidant levels in pre-eclamptic women (p < 0.001). The cardiac output and aortic wall distensibility were observed to be low in the cases.
   Conclusion: We conclude that abnormal lipid metabolism and high lipid peroxide concentrations observed in pre-eclampsia may result in oxidative stress and vascular dysfunction.
C1 [Bhat, Parvati, V; Priyanka, Alluri Naga] Manipal Acad Higher Educ, MMMC, Dr TMA Pai Hosp, Dept Obstet & Gynecol, Manipal 576104, Karnataka, India.
   [Vinod, Vinutha] Manipal Acad Higher Educ, MMMC, Dr TMA Pai Hosp, Manipal 576104, Karnataka, India.
   [Kamath, Asha] Manipal Acad Higher Educ, Prasanna Sch Publ Hlth, Dept Stat, Manipal 576104, Karnataka, India.
C3 Manipal Academy of Higher Education (MAHE); Manipal Academy of Higher
   Education (MAHE); Manipal Academy of Higher Education (MAHE)
RP Bhat, PV (corresponding author), Manipal Acad Higher Educ, MMMC, Dr TMA Pai Hosp, Dept Obstet & Gynecol, Manipal 576104, Karnataka, India.
EM parvati.bhat@manipal.edu; asha.kamath@manipal.edu
OI vinod, vinutha/0000-0001-8768-3251
CR Adiga Usha, 2007, J Chin Med Assoc, V70, P435, DOI 10.1016/S1726-4901(08)70034-0
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Bartha JL, 2008, EUR J OBSTET GYN R B, V137, P178, DOI 10.1016/j.ejogrb.2007.06.011
   Benzie IFF, 1996, ANAL BIOCHEM, V239, P70, DOI 10.1006/abio.1996.0292
   Christensen M, 2017, ACTA OBSTET GYN SCAN, V96, P1084, DOI 10.1111/aogs.13173
   Dane B, 2009, ARCH GYNECOL OBSTET, V280, P921, DOI 10.1007/s00404-009-1029-9
   EASTERLING TR, 1990, OBSTET GYNECOL, V76, P1061
   EVANS RW, 1994, METABOLISM, V43, P1196, DOI 10.1016/0026-0495(94)90065-5
   Fanshawe AE, 2013, J CARDIOL, V61, P99, DOI 10.1016/j.jjcc.2012.09.009
   Guray Y, 2010, TURK KARDIYOL DERN A, V38, P14
   Harsem NK, 2006, EUR J OBSTET GYN R B, V128, P209, DOI 10.1016/j.ejogrb.2005.11.014
   Hubel CA, 1996, AM J OBSTET GYNECOL, V174, P975, DOI 10.1016/S0002-9378(96)70336-8
   Kaihura C, 2009, AM J PHYSIOL-HEART C, V297, pH759, DOI 10.1152/ajpheart.01106.2008
   Kharb S, 2000, INT J GYNECOL OBSTET, V69, P23, DOI 10.1016/S0020-7292(99)00198-8
   Lykke JA, 2009, HYPERTENSION, V53, P944, DOI 10.1161/HYPERTENSIONAHA.109.130765
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Patil SB, 2008, INDIAN J CLIN BIOCHE, V23, P45, DOI 10.1007/s12291-008-0011-9
   Pfützner A, 2003, CLIN CHEM LAB MED, V41, P1234, DOI 10.1515/CCLM.2003.189
   POTTER JM, 1979, AM J OBSTET GYNECOL, V133, P165, DOI 10.1016/0002-9378(79)90469-1
   Reddy KS, 2006, B WORLD HEALTH ORGAN, V84, P461, DOI 10.2471/BLT.05.027037
   SAHN DJ, 1978, CIRCULATION, V58, P1072, DOI 10.1161/01.CIR.58.6.1072
   SATOH K, 1978, CLIN CHIM ACTA, V90, P37
   Sattar N, 2002, BMJ-BRIT MED J, V325, P157, DOI 10.1136/bmj.325.7356.157
   VISSER W, 1991, HYPERTENSION, V17, P1072, DOI 10.1161/01.HYP.17.6.1072
NR 24
TC 7
Z9 7
U1 0
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2210-7789
J9 PREGNANCY HYPERTENS
JI Pregnancy Hypertens.
PD JAN
PY 2019
VL 15
BP 130
EP 133
DI 10.1016/j.preghy.2018.12.010
PG 4
WC Obstetrics & Gynecology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Cardiovascular System & Cardiology
GA HM9LF
UT WOS:000459805100021
PM 30825910
DA 2025-06-11
ER

PT J
AU Saiki, M
   Robbins, W
   Tolentino, DA
   Macey, PM
   Nakata, A
   Li, J
AF Saiki, Mayumi
   Robbins, Wendie
   Tolentino, Dante Anthony
   Macey, Paul M.
   Nakata, Akinori
   Li, Jian
TI Associations of work-family conflict with changes in metabolic risk
   factors: a four-year longitudinal study
SO INDUSTRIAL HEALTH
LA English
DT Article
DE Longitudinal study; Occupational stress; Work-family conflict;
   Cardiometabolic risk factors; Cholesterol
ID JOB DEMANDS; HEALTH; STRESS; STRAIN; JAPAN
AB Cardiovascular disease (CVD) is becoming prevalent among younger people who have dual roles at both work and home. A possible contributor to CVD is conflict between work and home life. Thus, this study investigated the impact of work-to-family conflict (WFC) and family- to-work conflict (FWC) on metabolic risk factors. We used longitudinal data with a 4-yr interval from the Midlife in Japan study. 152 participants who were employed at baseline without missing variables of interest were included. We assessed the associations of baseline WFC and FWC with changes in metabolic risk factors between baseline and follow-up using Generalized Estimating Equations. After adjusting for baseline sociodemographic, work and family-related, and lifestyle factors, the fully adjusted model showed WFC was significantly associated with changes in low- density lipoprotein cholesterol (LDL-C) and Total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C) ratio. However, FWC was not significantly associated with changes in any metabolic risk factors. Our findings indicated a significant impact of WFC on LDL-C and TC/HDL-C ratio but no significant impact of FWC on metabolic health. Since these metabolic risk factors cause CVD, understanding the physiological responses to occupational psychosocial stress could help create primary prevention interventions and assess their effects on workers' metabolic health.
C1 [Saiki, Mayumi; Robbins, Wendie; Tolentino, Dante Anthony; Macey, Paul M.; Li, Jian] Univ Calif Los Angeles, Sch Nursing, Los Angeles, CA 90095 USA.
   [Robbins, Wendie; Li, Jian] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Environm Hlth Sci, Los Angeles, CA 90095 USA.
   [Nakata, Akinori] Int Univ Hlth & Welf, Grad Sch Med, Otawara, Japan.
   [Li, Jian] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90095 USA.
C3 University of California System; University of California Los Angeles;
   University of California System; University of California Los Angeles;
   International University of Health & Welfare; University of California
   System; University of California Los Angeles
RP Li, J (corresponding author), Univ Calif Los Angeles, Sch Nursing, Los Angeles, CA 90095 USA.; Li, J (corresponding author), Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Environm Hlth Sci, Los Angeles, CA 90095 USA.; Li, J (corresponding author), Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90095 USA.
EM jianli2019@ucla.edu
RI Tolentino, Dante Anthony/HNQ-6991-2023; Nakata, Akinori/HHC-4947-2022;
   Macey, Paul/B-5037-2008
OI Macey, Paul/0000-0003-4093-7458; Nakata, Akinori/0000-0003-3008-4615
FU U.S. National Institute on Aging [5R37AG027343]; National Institute for
   Occupational Safety and Health (NIOSH) Occupational and Environmental
   Health Nursing Program of the Southern California Education and Research
   Center (SCERC) from the U.S. Centers for Disease Control and Prevention
   (CDC) [T42 OH008412]
FX The Midlife in Japan (MIDJA) Study was supported by a grant from the
   U.S. National Institute on Aging (5R37AG027343) . MS was supported by
   the National Institute for Occupational Safety and Health (NIOSH)
   Occupational and Environmental Health Nursing Program of the Southern
   California Education and Research Center (SCERC) (Grant Agreement
   Number: T42 OH008412) from the U.S. Centers for Disease Control and
   Prevention (CDC) . Its contents are solely the responsibility of the
   authors and do not necessarily represent the official view of the U.S.
   CDC.
CR Allen TD, 2017, J OCCUP HEALTH PSYCH, V22, P259, DOI 10.1037/ocp0000065
   Andersson C, 2018, NAT REV CARDIOL, V15, P230, DOI 10.1038/nrcardio.2017.154
   Berkman LF, 2023, AM J PUBLIC HEALTH, V113, P1322, DOI 10.2105/AJPH.2023.307413
   Boylan JM, 2017, HEALTH PSYCHOL, V36, P449, DOI 10.1037/hea0000455
   Cardiovascular diseases (CVDs), Cardiovascular diseases (CVD)
   Greenhaus JH, 2012, J VOCAT BEHAV, V80, P246, DOI 10.1016/j.jvb.2011.12.007
   GREENHAUS JH, 1985, ACAD MANAGE REV, V10, P76, DOI 10.5465/AMR.1985.4277352
   Hartanto A, 2024, J PSYCHOSOM RES, V178, DOI 10.1016/j.jpsychores.2024.111594
   Hegewald J, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0251260
   Japan Ministry of Health Labour and Welfare, White paper on prevention of Karoshi 2022
   KARASEK RA, 1979, ADMIN SCI QUART, V24, P285, DOI 10.2307/2392498
   Kawakami N, 1995, INT J BEHAV MED, V2, P358, DOI 10.1207/s15327558ijbm0204_5
   Kiyoshige E, 2023, LANCET REG HEALTH-W, V31, DOI 10.1016/j.lanwpc.2022.100637
   Li J., 2014, PSYCHOSOCIAL FACTORS, P309
   Li J, 2022, ANN WORK EXPOS HEAL, V66, P822, DOI 10.1093/annweh/wxac026
   LIANG KY, 1986, BIOMETRIKA, V73, P13, DOI 10.1093/biomet/73.1.13
   Markus Hazel, 2014, ICPSR, DOI 10.3886/ICPSR34969
   Martin SS, 2024, CIRCULATION, V149, pE347, DOI 10.1161/CIR.0000000000001209
   Netemeyer RG, 1996, J APPL PSYCHOL, V81, P400, DOI 10.1037/0021-9010.81.4.400
   O'Donnell E, 2019, COMMUNITY WORK FAM, V22, P203, DOI 10.1080/13668803.2018.1440193
   Ogihara Y, 2017, FRONT PSYCHOL, V8, DOI 10.3389/fpsyg.2017.00695
   Oshio T, 2017, SOC SCI MED, V175, P36, DOI 10.1016/j.socscimed.2016.12.039
   Rocco PTP, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.119.012701
   Ryff C.D., 2008, SURVEY MIDLIFE JAPAN
   Ryff CD, 2018, Survey of Midlife in Japan (MIDJA 2): Biomarker project, 2013-2014
   Saiki M, 2024, SAF HEALTH WORK-KR, V15, P59, DOI 10.1016/j.shaw.2024.01.001
   Samur AA, 2014, PEERJ, V2, DOI 10.7717/peerj.648
   Schnall PL, 2016, INT J HEALTH SERV, V46, P656, DOI 10.1177/0020731416664687
   Shimazu A, 2013, J OCCUP HEALTH, V55, P234, DOI 10.1539/joh.12-0252-OA
   Shimazu A, 2010, IND HEALTH, V48, P766, DOI 10.2486/indhealth.MS1131
   Sugawara N, 2017, NEUROPSYCH DIS TREAT, V13, P779, DOI 10.2147/NDT.S127053
   Versey HS, 2020, J HEALTH PSYCHOL, V25, P1771, DOI 10.1177/1359105318764014
   W.H. Organization, 2019, World health statistics overview 2019: monitoring health for the SDGs, sustainable development goals
NR 33
TC 0
Z9 0
U1 1
U2 1
PU NATL INST OCCUPATIONAL SAFETY & HEALTH, JAPAN
PI KAWASAKI KANAGAWA
PA 21-1 NAGAO 6-CHOME TAMA-KU, KAWASAKI KANAGAWA, 214, JAPAN
SN 0019-8366
EI 1880-8026
J9 IND HEALTH
JI Ind. Health
PY 2024
VL 62
IS 6
BP 367
EP 376
DI 10.2486/indhealth.2024-0115
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA N4N2G
UT WOS:001364117800003
PM 39261023
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Oo, WJ
   Lim, CL
   Goh, MH
   Koh, RY
AF Oo, Wei Jet
   Lim, Chooi Ling
   Goh, Mun Hon
   Koh, Rhun Yian
TI Serum Cortisol and Cardiovascular Disease Risk - A Potential Biomarker
SO CURRENT CARDIOLOGY REVIEWS
LA English
DT Review
DE Serum cortisol; cardiovascular; stress; hormone; biomarker; mechanistic
   parameters
ID CUSHINGS-SYNDROME; GENE-EXPRESSION; ADIPOSE-TISSUE; ORAL
   GLUCOCORTICOIDS; GLUCOSE-METABOLISM; ADRENAL-TUMORS; ACTIVE DISEASE;
   CHRONIC STRESS; PHASE-III; LINC 3
AB Cardiovascular disease (CVD), the leading cause of death globally, poses a significant burden on the healthcare sector. Its association with stress and Cushing's Syndrome has driven cortisol, the 'stress hormone,' to be a potential candidate in determining CVD risk. Cortisol synthesis and release through the hypothalamic-pituitary-adrenal (HPA) axis are regulated by several hormones and receptors involved in the pathological cascade towards CVD. Evidence suggests that metabolic syndrome plays a major role in cortisol-mediated CVD risk. On the other hand, non-metabolic features are also implicated when the association between cortisol and CVD risk remains significant upon normalisation of metabolic parameters. Correspondingly, the treatment for hypercortisolism is often found effective in lowering CVD risk. Despite available evidence, several factors continue to hinder the clinical use of cortisol as a risk biomarker for CVD. This review provides an insight into the role of serum cortisol in CVD progression and risk, with emphasis on the mechanistic features and parameters.
C1 [Oo, Wei Jet; Lim, Chooi Ling; Koh, Rhun Yian] IMU Univ, Sch Hlth Sci, Div Appl Biomed Sci & Biotechnol, 126 Jalan Jalil Perkasa 19, Kuala Lumpur 57000, Malaysia.
   [Goh, Mun Hon] Natl Heart Inst, Lab & Blood Serv Dept, 145 Jalan Tun Razak, Kuala Lumpur 50400, Malaysia.
C3 Institute Jantung Negara
RP Lim, CL (corresponding author), IMU Univ, Sch Hlth Sci, Div Appl Biomed Sci & Biotechnol, 126 Jalan Jalil Perkasa 19, Kuala Lumpur 57000, Malaysia.
EM chooi_linglim@imu.edu.my
RI Koh, Rhun Yian/KHZ-6083-2024
OI Lim, Chooi Ling/0000-0002-2926-892X
FU School of Health Sciences, IMU University, Malaysia
FX This work was supported by the School of Health Sciences, IMU
   University, Malaysia.
CR Abell JG, 2016, PSYCHONEUROENDOCRINO, V73, P148, DOI 10.1016/j.psyneuen.2016.07.214
   Abraham TM, 2015, CIRCULATION, V132, P1639, DOI 10.1161/CIRCULATIONAHA.114.015000
   Adam EK, 2017, PSYCHONEUROENDOCRINO, V83, P25, DOI 10.1016/j.psyneuen.2017.05.018
   Albani A, 2018, ENDOCRINE, V61, P118, DOI 10.1007/s12020-018-1524-5
   Allara E, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0272807
   [Anonymous], 2022, American Heart Association 2022 heart disease stroke statistical update fact sheet global burden of disease
   Arab Dolatabadi A., J Med Life
   Arnaldi G, 2010, NEUROENDOCRINOLOGY, V92, P86, DOI 10.1159/000314213
   Arruda M, 2017, J HUM HYPERTENS, V32, P3, DOI 10.1038/s41371-017-0011-4
   Avenatti E, 2017, ENDOCRINE, V55, P547, DOI 10.1007/s12020-016-0986-6
   Bailey MA, 2017, CURR HYPERTENS REP, V19, DOI 10.1007/s11906-017-0797-z
   Bancos I, 2016, EUR J ENDOCRINOL, V175, pR283, DOI 10.1530/EJE-16-0465
   Benjamin EJ, 2019, CIRCULATION, V139, pE56, DOI [10.1161/CIR.0000000000000659, 10.1161/CIR.0000000000000746]
   Berawi K. N., 2018, Biomedical & Pharmacology Journal, V11, P201
   Boffa MB, 2003, J BIOL CHEM, V278, P9250, DOI 10.1074/jbc.M209588200
   Bongsebandhu-phubhakdi C, 2023, TROP MED INFECT DIS, V8, DOI 10.3390/tropicalmed8030146
   Brotman DJ, 2006, THROMB RES, V118, P247, DOI 10.1016/j.thromres.2005.06.006
   Bruce IN, 2023, RHEUMATOLOGY, V62, P1526, DOI 10.1093/rheumatology/keac491
   Cardiovascular diseases (CVDs), 2021, About us
   Chait A, 2020, FRONT CARDIOVASC MED, V7, DOI 10.3389/fcvm.2020.00022
   Cheng S, 2014, CIRCULATION, V130, P820, DOI 10.1161/CIRCULATIONAHA.113.008506
   Cohen BE, 2015, AM J HYPERTENS, V28, P1295, DOI 10.1093/ajh/hpv047
   Cohen S, 2012, P NATL ACAD SCI USA, V109, P5995, DOI 10.1073/pnas.1118355109
   Coulden A, 2022, PITUITARY, V25, P750, DOI 10.1007/s11102-022-01258-4
   Crawford AA, 2019, EUR J ENDOCRINOL, V181, P429, DOI 10.1530/EJE-19-0161
   Dalle H, 2019, DIABETES, V68, P305, DOI 10.2337/db17-1577
   De Leo M, 2010, NEUROENDOCRINOLOGY, V92, P50, DOI 10.1159/000318566
   Del Gobbo LC, 2013, AM J CLIN NUTR, V98, P160, DOI 10.3945/ajcn.112.053132
   Detomas M, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.903545
   Díaz-Castro F, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00429
   Einarson TR, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0728-6
   Evans LC, 2016, CIRCULATION, V133, P1360, DOI 10.1161/CIRCULATIONAHA.115.019341
   Faggiano A, 2003, J CLIN ENDOCR METAB, V88, P2527, DOI 10.1210/jc.2002-021558
   Fardet L, 2014, DRUGS, V74, P1731, DOI 10.1007/s40265-014-0282-9
   Fischli S, 2021, J ENDOCR SOC, V5, DOI 10.1210/jendso/bvab047
   Fleseriu M., 2021, J. Endocr. Soc, V5, pA521, DOI [10.1210/jendso/bvab048.1063, DOI 10.1210/JENDSO/BVAB048.1063]
   Fleseriu M, 2022, EUR J ENDOCRINOL, V187, P531, DOI 10.1530/EJE-22-0317
   Gadelha M, 2022, J CLIN ENDOCR METAB, V107, pE2882, DOI 10.1210/clinem/dgac178
   Garcez A, 2018, PSYCHONEUROENDOCRINO, V95, P50, DOI 10.1016/j.psyneuen.2018.05.023
   Giordano R, 2011, CLIN ENDOCRINOL, V75, P354, DOI 10.1111/j.1365-2265.2011.04055.x
   Gonzalez D, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-44693-3
   Guo C, 2008, CIRCULATION, V117, P2253, DOI 10.1161/CIRCULATIONAHA.107.748640
   Hackett RA, 2016, J CLIN ENDOCR METAB, V101, P619, DOI 10.1210/jc.2015-2853
   Halleux CM, 1999, J CLIN ENDOCR METAB, V84, P4097, DOI 10.1210/jc.84.11.4097
   Henley C., 2020, HPA axis. Foundations of Neuroscience. Simple Book
   Herman JP, 2016, COMPR PHYSIOL, V6, P603, DOI 10.1002/cphy.c150015
   Hornsby W Guy, 2020, J Funct Morphol Kinesiol, V5, DOI 10.3390/jfmk5020044
   Iob E, 2019, CURR CARDIOL REP, V21, DOI 10.1007/s11886-019-1208-7
   Isidori AM, 2015, J HYPERTENS, V33, P44, DOI 10.1097/HJH.0000000000000415
   Jin YX, 2022, INT J ENDOCRINOL, V2022, DOI [10.1049/icp.2022.1184, 10.1155/2022/5680170]
   Johannesdottir SA, 2013, JAMA INTERN MED, V173, P743, DOI 10.1001/jamainternmed.2013.122
   Jones C, 2021, PHYSIOL REP, V8, DOI 10.14814/phy2.14644
   Joseph JJ, 2017, METABOLISM, V68, P95, DOI 10.1016/j.metabol.2016.12.001
   Kamba A, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0166077
   Kamenicky P, 2014, J CLIN ENDOCR METAB, V99, pE2144, DOI 10.1210/jc.2014-1783
   Kaze AD, 2021, J AM HEART ASSOC, V10, DOI 10.1161/JAHA.120.016947
   Kluwe B, 2021, OBESITY, V29, P418, DOI 10.1002/oby.23056
   Kwok MK, 2020, BMC MED, V18, DOI 10.1186/s12916-020-01831-3
   Larsson SC, 2021, J CLIN ENDOCR METAB, V106, pE2521, DOI 10.1210/clinem/dgab219
   Lee HW, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0187066
   Lee NR, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-77281-x
   Li DF, 2020, GLAND SURG, V9, P43, DOI 10.21037/gs.2019.11.03
   Licinio J, 1997, NAT MED, V3, P575, DOI 10.1038/nm0597-575
   Linden MA, 2023, MOL METAB, V74, DOI 10.1016/j.molmet.2023.101751
   Liu JK, 2010, J CLIN ENDOCR METAB, V95, P5419, DOI 10.1210/jc.2010-1378
   Lopez D, 2016, ANN INTERN MED, V165, P533, DOI 10.7326/M16-0547
   Ma CX, 2022, CARDIOVASC DIABETOL, V21, DOI 10.1186/s12933-022-01516-6
   Mac Giollabhui N, 2021, MOL PSYCHIATR, V26, P3302, DOI 10.1038/s41380-020-00867-4
   Magiakou MA, 2006, BEST PRACT RES CL EN, V20, P467, DOI 10.1016/j.beem.2006.07.006
   Matthews K, 2006, PSYCHOSOM MED, V68, P657, DOI 10.1097/01.psy.0000244071.42939.0e
   Mazgelyte Egle, 2021, Open Med (Wars), V16, P873, DOI 10.1515/med-2021-0298
   McLaughlin T, 2016, DIABETES, V65, P1245, DOI 10.2337/db15-1213
   Mebrahtu TF, 2020, CAN MED ASSOC J, V192, pE295, DOI 10.1503/cmaj.191012
   Moor VJA, 2017, INT J VASC MED, V2017, DOI 10.1155/2017/6061306
   Morgan SA, 2014, P NATL ACAD SCI USA, V111, pE2482, DOI 10.1073/pnas.1323681111
   Muscogiuri G, 2011, CLIN ENDOCRINOL, V74, P300, DOI 10.1111/j.1365-2265.2010.03928.x
   Nieman LK, 2015, J CLIN ENDOCR METAB, V100, P2807, DOI 10.1210/jc.2015-1818
   Niroumand Shabnam, 2015, Med J Islam Repub Iran, V29, P240
   Norman A., 2015, Hormones, V3rd ed, P1, DOI [10.1016/B978-0-08-091906-5.00001-X, DOI 10.1016/B978-0-08-091906-5.00001-X]
   Ormazabal V, 2018, CARDIOVASC DIABETOL, V17, DOI 10.1186/s12933-018-0762-4
   Ortiz R, 2019, PSYCHONEUROENDOCRINO, V103, P25, DOI 10.1016/j.psyneuen.2018.12.237
   Osborne MT, 2020, CIRC-CARDIOVASC IMAG, V13, DOI 10.1161/CIRCIMAGING.120.010931
   Patel SA, 2015, ANN INTERN MED, V163, P245, DOI 10.7326/M14-1753
   Petersenn S, 2017, ENDOCRINE, V57, P156, DOI 10.1007/s12020-017-1316-3
   Pickering G, 2020, NUTRIENTS, V12, DOI 10.3390/nu12123672
   Pimenta E, 2012, ENDOCRINOLOGY, V153, P5137, DOI 10.1210/en.2012-1573
   Pivonello R, 2020, LANCET DIABETES ENDO, V8, P748, DOI 10.1016/S2213-8587(20)30240-0
   Pivonello R, 2016, LANCET DIABETES ENDO, V4, P611, DOI 10.1016/S2213-8587(16)00086-3
   Podbregar A, 2020, BMC ENDOCR DISORD, V20, DOI 10.1186/s12902-020-00599-0
   Preis SR, 2010, OBESITY, V18, P2191, DOI 10.1038/oby.2010.59
   Pujades-Rodriguez M, 2020, PLOS MED, V17, DOI 10.1371/journal.pmed.1003432
   Rao R, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-47605-7
   Rockall AG, 2003, EUR J ENDOCRINOL, V149, P543, DOI 10.1530/eje.0.1490543
   Roerink SHPP, 2017, OBESITY, V25, P1369, DOI 10.1002/oby.21887
   Ross R, 2020, NAT REV ENDOCRINOL, V16, P177, DOI 10.1038/s41574-019-0310-7
   Ruiz-Castell M, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-88587-9
   Ryder AL, 2021, FAM PRACT, V38, P365, DOI 10.1093/fampra/cmab031
   Samson SL, 2021, PITUITARY, V24, P887, DOI 10.1007/s11102-021-01161-4
   Sarfraz A, 2021, CLIN APPL THROMB-HEM, V27, DOI 10.1177/1076029621993573
   Savas M, 2017, INT J MED SCI, V14, P615, DOI 10.7150/ijms.19213
   Scaroni C, 2017, ENDOCR REV, V38, P189, DOI 10.1210/er.2016-1105
   Schutten JC, 2021, CLIN ENDOCRINOL, V94, P150, DOI 10.1111/cen.14350
   SHIBATA H, 1995, HYPERTENSION, V26, P1003, DOI 10.1161/01.HYP.26.6.1003
   Simeoli C, 2020, J ENDOCRINOL INVEST, V43, P57, DOI 10.1007/s40618-019-01077-8
   Song H, 2019, BMJ-BRIT MED J, V365, DOI 10.1136/bmj.l1255
   Souverein PC, 2004, HEART, V90, P859, DOI 10.1136/hrt.2003.020180
   Stephens MAC, 2012, ALCOHOL RES-CURR REV, V34, P468
   Stimson RH, 2017, DIABETES OBES METAB, V19, P883, DOI 10.1111/dom.12899
   Stomby A, 2022, FRONT CARDIOVASC MED, V8, DOI 10.3389/fcvm.2021.765000
   Tawakol A, 2017, LANCET, V389, P834, DOI 10.1016/S0140-6736(16)31714-7
   Thau L., 2022, Physiology
   Tholen S, 2022, CELL REP, V39, DOI 10.1016/j.celrep.2022.111018
   Tomasiuk R, 2022, AM J MENS HEALTH, V16, DOI 10.1177/15579883221108895
   Trandafir LM, 2021, DIAGNOSTICS, V11, DOI 10.3390/diagnostics11040735
   Ulrich-Lai YM, 2006, AM J PHYSIOL-ENDOC M, V291, pE965, DOI 10.1152/ajpendo.00070.2006
   Victorio JA, 2016, HYPERTENSION, V68, P726, DOI 10.1161/HYPERTENSIONAHA.116.07911
   Wagner J, 2019, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00805
   Zhao SG, 2021, CIRC RES, V128, P136, DOI 10.1161/CIRCRESAHA.120.314458
   Zilio M, 2014, CLIN ENDOCRINOL, V80, P403, DOI 10.1111/cen.12299
NR 119
TC 0
Z9 0
U1 0
U2 0
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-403X
EI 1875-6557
J9 CURR CARDIOL REV
JI Curr. Cardiol. Rev.
PY 2025
VL 21
IS 3
AR E1573403X328499
DI 10.2174/011573403X328499241106064553
PG 11
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA 2JS0S
UT WOS:001484278100008
PM 39754772
DA 2025-06-11
ER

PT J
AU Groer, M
   Murphy, R
   Bunnell, W
   Salomon, K
   Van Eepoel, J
   Rankin, B
   White, K
   Bykowski, C
AF Groer, Maureen
   Murphy, Randall
   Bunnell, William
   Salomon, Kristin
   Van Eepoel, Jeanne
   Rankin, Blake
   White, Kristi
   Bykowski, Cathy
TI Salivary Measures of Stress and Immunity in Police Officers Engaged in
   Simulated Critical Incident Scenarios
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
ID INTERLEUKIN-6 LEVELS; METABOLIC SYNDROME; COLLECTION METHOD;
   IMMUNOGLOBULIN-A; ALPHA-AMYLASE; CORTISOL; SERUM; WORK; ATHEROSCLEROSIS;
   EXERCISE
AB Objective: This research investigated the effects of a critical incident lethal force scenario on a panel of salivary biomarkers, measured at baseline and then at 10 and 30 minutes postscenario, in 141 law enforcement volunteer officers. Methods: Officers were randomly assigned to two virtual reality scenarios. One scenario was brief and involved a police officer chasing a suspect on a motorcycle, confronting the suspect who draws a gun and shoots the police officer. The other scenario involved a lengthy chase by the police officer through a workplace of an armed perpetrator ultimately engaging in gunfire with the police officer. Saliva was analyzed for cortisol, secretory immunoglobulin A (sIgA), interleukin-6, and alpha-amylase concentrations. Results: The "workplace" scenario produced the largest responses in biomarkers, with significant rises in cortisol, interleukin-6, alpha-amylase, and secretory immunoglobulin A. These data suggest that virtual reality can produce stress and immune effects. Conclusions: This research suggests that virtual reality scenarios produce physiologic stress responses, mimicking occupational stress.
C1 [Groer, Maureen; Van Eepoel, Jeanne; Rankin, Blake] Univ S Florida, Coll Nursing, Tampa, FL 33612 USA.
   [Salomon, Kristin; White, Kristi; Bykowski, Cathy] Univ S Florida, Dept Psychol, Tampa, FL 33612 USA.
   [Murphy, Randall; Bunnell, William] Meggitts Training Syst Inc, Atlanta, GA USA.
C3 State University System of Florida; University of South Florida; State
   University System of Florida; University of South Florida
RP Groer, M (corresponding author), Univ S Florida, Coll Nursing, 12910 Bruce B Downs Blvd, Tampa, FL 33612 USA.
EM mgroer@health.usf.edu
CR Altemus M, 2006, ANN NY ACAD SCI, V1071, P167, DOI 10.1196/annals.1364.013
   Black PH, 2006, MED HYPOTHESES, V67, P879, DOI 10.1016/j.mehy.2006.04.008
   Castellano Cherie, 2003, Int J Emerg Ment Health, V5, P211
   Chatterton RT, 1996, CLIN PHYSIOL, V16, P433, DOI 10.1111/j.1475-097X.1996.tb00731.x
   COOLENS J, 1987, J STEROID BIOCHEM, V2, P197
   Cox AJ, 2008, EUR J APPL PHYSIOL, V103, P477, DOI 10.1007/s00421-008-0722-x
   Ehlert U, 2006, J CLIN ENDOCR METAB, V91, P5130, DOI 10.1210/jc.2006-0461
   Fahlman MM, 2005, MED SCI SPORT EXER, V37, P374, DOI 10.1249/01.MSS.0000155432.67020.88
   Hellhammer DH, 2009, PSYCHONEUROENDOCRINO, V34, P163, DOI 10.1016/j.psyneuen.2008.10.026
   Joseph PN, 2009, J OCCUP ENVIRON MED, V51, P700, DOI 10.1097/JOM.0b013e3181a02252
   Kiecolt-Glaser JK, 2003, P NATL ACAD SCI USA, V100, P9090, DOI 10.1073/pnas.1531903100
   Maguen S, 2009, J NERV MENT DIS, V197, P754, DOI 10.1097/NMD.0b013e3181b975f8
   Minetto M, 2005, EUR J APPL PHYSIOL, V93, P679, DOI 10.1007/s00421-004-1241-z
   Minetto MA, 2007, EUR J APPL PHYSIOL, V101, P249, DOI 10.1007/s00421-007-0484-x
   Otsuki T, 2004, Int J Immunopathol Pharmacol, V17, P45
   Poll EM, 2007, CLIN CHIM ACTA, V382, P15, DOI 10.1016/j.cca.2007.03.009
   Ring C, 2000, PSYCHOPHYSIOLOGY, V37, P634, DOI 10.1111/1469-8986.3750634
   SCANNAPIECO FA, 1994, CRIT REV ORAL BIOL M, V5, P203, DOI 10.1177/10454411940050030201
   SIDDLE B, 2005, COMBAT HUMAN FACTORS, P1
   Sjögren E, 2006, BRAIN BEHAV IMMUN, V20, P270, DOI 10.1016/j.bbi.2005.08.001
   Skosnik PD, 2000, INT J PSYCHOPHYSIOL, V36, P59, DOI 10.1016/S0167-8760(99)00100-2
   Sluzewska A, 1996, PSYCHIAT RES, V64, P161, DOI 10.1016/S0165-1781(96)02783-7
   Strazdins L, 2005, J IMMUNOL METHODS, V307, P167, DOI 10.1016/j.jim.2005.09.010
   Takatsuji K, 2008, BIOMED RES-TOKYO, V29, P221, DOI 10.2220/biomedres.29.221
   Thompson MM., 2006, Int J Stress Manag, V13, P494, DOI [DOI 10.1037/1072-5245.13.4.494, 10.1037/1072-5245.13.4.494]
   Tiollier E, 2005, EUR J APPL PHYSIOL, V93, P421, DOI 10.1007/s00421-004-1231-1
   Violanti JM, 2006, ANN EPIDEMIOL, V16, P148, DOI 10.1016/j.annepidem.2005.07.054
   Violanti John M, 2008, Int J Emerg Ment Health, V10, P299
   Violanti JM, 2009, ARCH ENVIRON OCCUP H, V64, P194, DOI 10.1080/19338240903241259
   Yoo HL, 2009, J OCCUP ENVIRON MED, V51, P46, DOI 10.1097/JOM.0b013e31817f9e43
NR 30
TC 55
Z9 67
U1 0
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1076-2752
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD JUN
PY 2010
VL 52
IS 6
BP 595
EP 602
DI 10.1097/JOM.0b013e3181e129da
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 608FM
UT WOS:000278568500004
PM 20523239
DA 2025-06-11
ER

PT J
AU Arnold, SE
   Lucki, I
   Brookshire, BR
   Carlson, GC
   Browne, CA
   Kazi, H
   Bang, S
   Choi, BR
   Chen, Y
   McMullen, MF
   Kim, SF
AF Arnold, Steven E.
   Lucki, Irwin
   Brookshire, Bethany R.
   Carlson, Gregory C.
   Browne, Caroline A.
   Kazi, Hala
   Bang, Sookhee
   Choi, Bo-Ran
   Chen, Yong
   McMullen, Mary F.
   Kim, Sangwon F.
TI High fat diet produces brain insulin resistance, synaptodendritic
   abnormalities and altered behavior in mice
SO NEUROBIOLOGY OF DISEASE
LA English
DT Article
DE Insulin; Insulin receptor substrate 1; Alct; GSK3; mTOR; IPMK; Synapse;
   Spine; Working memory
ID TYPE-2 DIABETES-MELLITUS; HIPPOCAMPAL SYNAPTIC PLASTICITY; ACTIVATED
   PROTEIN-KINASE; LONG-TERM POTENTIATION; METABOLIC SYNDROME; INDUCED
   OBESITY; FOOD-INTAKE; MEMORY; DEPRESSION; RECEPTOR
AB Insulin resistance and other features of the metabolic syndrome are increasingly recognized for their effects on cognitive health. To ascertain mechanisms by which this occurs, we fed mice a very high fat diet (60% kcal by fat) for 17 days or a moderate high fat diet (HFD, 45% kcal by fat) for 8 weeks and examined changes in brain insulin signaling responses, hippocampal synaptodendritic protein expression, and spatial working memory. Compared to normal control diet mice, cerebral cortex tissues of HFD mice were insulin-resistant as evidenced by failed activation of Akt, S6 and GSK3 beta with ex-vivo insulin stimulation. Importantly, we found that expression of brain IPMK, which is necessary for mTOR/Akt signaling, remained decreased in HFD mice upon activation of AMPK. HFD mouse hippocampus exhibited increased expression of serine-phosphorylated insulin receptor substrate 1 (IRS1-pS(616)), a marker of insulin resistance, as well as decreased expression of PSD-95, a scaffolding protein enriched in post-synaptic densities, and synaptopodin, an actin-associated protein enriched in spine apparatuses. Spatial working memory was impaired as assessed by decreased spontaneous alternation in a T-maze. These findings indicate that HFD is associated with telencephalic insulin resistance and deleterious effects on synaptic integrity and cognitive behaviors. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Arnold, Steven E.; Lucki, Irwin; Brookshire, Bethany R.; Carlson, Gregory C.; Browne, Caroline A.; Kazi, Hala; Bang, Sookhee; Choi, Bo-Ran; Chen, Yong; McMullen, Mary F.; Kim, Sangwon F.] Univ Penn, Dept Psychiat, Ctr Neurobiol & Behav, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania
RP Arnold, SE (corresponding author), 2205 Translat Res Labs, 125 Soth 31st St, Philadelphia, PA 19104 USA.
EM steven.arnold@uphs.upenn.edu; sangwonk@mail.med.upenn.edu
RI Browne, Caroline/ADZ-5051-2022; Arnold, Steven/J-7546-2012; Lucki,
   Irwin/AAX-6061-2021
OI Browne, Caroline/0000-0001-7463-7870; Choi, Bo-Ran/0000-0002-1366-4688
FU NIH [R01 AG039478, RO1 DK084336, R01 MH086599, T32 MH14654]; University
   of Pennsylvania Institute on Aging; Allen H and Selma W. Berkman
   Charitable Trust; BrightFocus Foundation
FX This work was supported by grants from the NIH R01 AG039478 RO1
   DK084336, R01 MH086599 and T32 MH14654, the Allen H and Selma W. Berkman
   Charitable Trust, the BrightFocus Foundation and pilot grants from the
   University of Pennsylvania Institute on Aging.
CR Abbott MA, 1999, J NEUROSCI, V19, P7300, DOI 10.1523/JNEUROSCI.19-17-07300.1999
   Amato L, 1996, DIABETES METAB, V22, P314
   Artola A, 2005, EUR J NEUROSCI, V22, P169, DOI 10.1111/j.1460-9568.2005.04205.x
   Baker LD, 2011, ARCH NEUROL-CHICAGO, V68, P51, DOI 10.1001/archneurol.2010.225
   Bang S, 2012, NEUROSCI LETT, V521, P142, DOI 10.1016/j.neulet.2012.05.073
   Bang S, 2012, P NATL ACAD SCI USA, V109, P616, DOI 10.1073/pnas.1119751109
   Biessels GJ, 2006, LANCET NEUROL, V5, P64, DOI 10.1016/S1474-4422(05)70284-2
   Bockmann J, 2002, J NEUROCHEM, V83, P1013, DOI 10.1046/j.1471-4159.2002.01204.x
   Boitard C, 2012, HIPPOCAMPUS, V22, P2095, DOI 10.1002/hipo.22032
   Can ÖD, 2012, BEHAV PHARMACOL, V23, P582, DOI 10.1097/FBP.0b013e328356c3f2
   Chakraborty A, 2010, CELL, V143, P897, DOI 10.1016/j.cell.2010.11.032
   Chen Y, 2013, J NEUROSCI, V33, P3582, DOI 10.1523/JNEUROSCI.1497-12.2013
   Chiu SL, 2008, NEURON, V58, P708, DOI 10.1016/j.neuron.2008.04.014
   Cohen JW, 2011, SYNAPSE, V65, P763, DOI 10.1002/syn.20900
   Correia SC, 2011, AGEING RES REV, V10, P264, DOI 10.1016/j.arr.2011.01.001
   Dagon Y, 2012, CELL METAB, V16, P104, DOI 10.1016/j.cmet.2012.05.010
   Hert M, 2012, NAT REV ENDOCRINOL, V8, P114, DOI 10.1038/nrendo.2011.156
   de la Monte SM, 2009, BMB REP, V42, P475, DOI 10.5483/BMBRep.2009.42.8.475
   Dudchenko PA, 2004, NEUROSCI BIOBEHAV R, V28, P699, DOI 10.1016/j.neubiorev.2004.09.002
   Finger BC, 2010, PSYCHOPHARMACOLOGY, V210, P559, DOI 10.1007/s00213-010-1858-z
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   Gispen WH, 2000, TRENDS NEUROSCI, V23, P542, DOI 10.1016/S0166-2236(00)01656-8
   Gong R, 2006, J BIOL CHEM, V281, P18802, DOI 10.1074/jbc.M512524200
   GREENWOOD CE, 1990, BEHAV NEURAL BIOL, V53, P74, DOI 10.1016/0163-1047(90)90831-P
   Gupta A, 2011, NEUROPHARMACOLOGY, V60, P910, DOI 10.1016/j.neuropharm.2011.01.033
   Haan MN, 2006, NAT CLIN PRACT NEURO, V2, P159, DOI 10.1038/ncpneuro0124
   Hardie DG, 2012, NAT REV MOL CELL BIO, V13, P251, DOI 10.1038/nrm3311
   Heppner PS, 2009, BMC MED, V7, DOI 10.1186/1741-7015-7-1
   Hernandez D, 2012, NEURON, V74, P277, DOI 10.1016/j.neuron.2012.02.020
   Heyward FD, 2012, NEUROBIOL LEARN MEM, V98, P25, DOI 10.1016/j.nlm.2012.04.005
   Ho N, 2013, NEUROSCI BIOBEHAV R, V37, P1346, DOI 10.1016/j.neubiorev.2013.03.010
   Ho N, 2012, PHYSIOL BEHAV, V105, P702, DOI 10.1016/j.physbeh.2011.09.003
   Hughes RN, 2004, NEUROSCI BIOBEHAV R, V28, P497, DOI 10.1016/j.neubiorev.2004.06.006
   Hwang LL, 2010, OBESITY, V18, P463, DOI 10.1038/oby.2009.273
   Kahn BB, 2005, CELL METAB, V1, P15, DOI 10.1016/j.cmet.2004.12.003
   Kalender A, 2010, CELL METAB, V11, P390, DOI 10.1016/j.cmet.2010.03.014
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Kim SF, 2007, P NATL ACAD SCI USA, V104, P3456, DOI 10.1073/pnas.0611417104
   Kim S, 2011, CELL METAB, V13, P215, DOI 10.1016/j.cmet.2011.01.007
   Kindler S, 2012, ADV EXP MED BIOL, V970, P285, DOI 10.1007/978-3-7091-0932-8_13
   Knol MJ, 2006, DIABETOLOGIA, V49, P837, DOI 10.1007/s00125-006-0159-x
   Lee CC, 2011, NEUROPHARMACOLOGY, V61, P867, DOI 10.1016/j.neuropharm.2011.06.003
   Li XL, 2002, NEUROSCIENCE, V113, P607, DOI 10.1016/S0306-4522(02)00162-8
   Lindqvist A, 2006, EUR J NEUROL, V13, P1385, DOI 10.1111/j.1468-1331.2006.01500.x
   Maag D, 2011, P NATL ACAD SCI USA, V108, P1391, DOI 10.1073/pnas.1017831108
   Magarinos AM, 1997, P NATL ACAD SCI USA, V94, P14002, DOI 10.1073/pnas.94.25.14002
   Magariños AM, 2000, P NATL ACAD SCI USA, V97, P11056, DOI 10.1073/pnas.97.20.11056
   McEvoy JP, 2005, SCHIZOPHR RES, V80, P19, DOI 10.1016/j.schres.2005.07.014
   McIntyre RS, 2010, J AFFECT DISORDERS, V126, P366, DOI 10.1016/j.jad.2010.04.012
   Metlakunta AS, 2008, ENDOCRINOLOGY, V149, P1121, DOI 10.1210/en.2007-1307
   Mielke JG, 2006, NEUROSCIENCE, V143, P165, DOI 10.1016/j.neuroscience.2006.07.055
   Mielke JG, 2011, PROG MOL BIOL TRANSL, V98, P133, DOI 10.1016/B978-0-12-385506-0.00004-1
   Miller RA, 2013, NATURE, V494, P256, DOI 10.1038/nature11808
   Minokoshi Y, 2004, NATURE, V428, P569, DOI 10.1038/nature02440
   Minokoshi Y, 2002, NATURE, V415, P339, DOI 10.1038/415339a
   Morrison CD, 2010, J NEUROCHEM, V114, P1581, DOI 10.1111/j.1471-4159.2010.06865.x
   Neumann KF, 2008, CURR ALZHEIMER RES, V5, P438, DOI 10.2174/156720508785908919
   Obrosova IG, 2007, DIABETES, V56, P2598, DOI 10.2337/db06-1176
   Okamura F, 2000, METABOLISM, V49, P1255, DOI 10.1053/meta.2000.9515
   Pan A, 2010, ARCH INTERN MED, V170, P1884, DOI 10.1001/archinternmed.2010.356
   Peineau S, 2007, NEURON, V53, P703, DOI 10.1016/j.neuron.2007.01.029
   Pistell PJ, 2010, J NEUROIMMUNOL, V219, P25, DOI 10.1016/j.jneuroim.2009.11.010
   Porter DW, 2010, DIABETES OBES METAB, V12, P891, DOI 10.1111/j.1463-1326.2010.01259.x
   Porter D, 2012, PEPTIDES, V35, P1, DOI 10.1016/j.peptides.2012.03.014
   Porter W.D., 2012, INT J OBES LOND, P678
   Pouwer F, 2003, DIABETOLOGIA, V46, P892, DOI 10.1007/s00125-003-1124-6
   Profenno LA, 2010, BIOL PSYCHIAT, V67, P505, DOI 10.1016/j.biopsych.2009.02.013
   Reaven GM, 2011, J INTERN MED, V269, P127, DOI 10.1111/j.1365-2796.2010.02325.x
   Schneider CA, 2012, NAT METHODS, V9, P671, DOI 10.1038/nmeth.2089
   Schrijvers EMC, 2010, NEUROLOGY, V75, P1982, DOI 10.1212/WNL.0b013e3181ffe4f6
   Smillie KJ, 2012, TRAFFIC, V13, P1004, DOI 10.1111/j.1600-0854.2012.01365.x
   Stranahan AM, 2008, HIPPOCAMPUS, V18, P1085, DOI 10.1002/hipo.20470
   Talbot K, 2012, J CLIN INVEST, V122, P1316, DOI 10.1172/JCI59903
   Tucker KR, 2012, PHYSIOL BEHAV, V107, P424, DOI 10.1016/j.physbeh.2012.09.007
   Valladolid-Acebes I, 2011, NEUROBIOL LEARN MEM, V95, P80, DOI 10.1016/j.nlm.2010.11.007
   Valladolid-Acebes I, 2012, AM J PHYSIOL-ENDOC M, V302, pE396, DOI 10.1152/ajpendo.00343.2011
   van der Heide LP, 2005, J NEUROCHEM, V94, P1158, DOI 10.1111/j.1471-4159.2005.03269.x
   Weber-Hamann B, 2006, J CLIN PSYCHIAT, V67, P1856, DOI 10.4088/JCP.v67n1204
   WERTHER GA, 1989, J NEUROENDOCRINOL, V1, P369, DOI 10.1111/j.1365-2826.1989.tb00131.x
   Williams LM, 2012, P NUTR SOC, V71, P521, DOI 10.1017/S002966511200078X
   Winocur G, 2005, NEUROBIOL AGING, V26, pS46, DOI 10.1016/j.neurobiolaging.2005.09.003
   Winzell MS, 2004, DIABETES, V53, pS215, DOI 10.2337/diabetes.53.suppl_3.S215
   Wolfgang MJ, 2006, ANNU REV NUTR, V26, P23, DOI 10.1146/annurev.nutr.25.050304.092532
   Xue BZ, 2006, J PHYSIOL-LONDON, V574, P73, DOI 10.1113/jphysiol.2006.113217
   Yamada-Goto N, 2012, J NEUROENDOCRINOL, V24, P1120, DOI 10.1111/j.1365-2826.2012.02327.x
   Zhao WQ, 2009, BBA-MOL BASIS DIS, V1792, P482, DOI 10.1016/j.bbadis.2008.10.014
NR 86
TC 248
Z9 285
U1 1
U2 62
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0969-9961
EI 1095-953X
J9 NEUROBIOL DIS
JI Neurobiol. Dis.
PD JUL
PY 2014
VL 67
BP 79
EP 87
DI 10.1016/j.nbd.2014.03.011
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA AH9PU
UT WOS:000336475100009
PM 24686304
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Florczak, E
   Prejbisz, A
   Szwench-Pietrasz, E
   Sliwinski, P
   Bielen, P
   Klisiewicz, A
   Michalowska, I
   Warchol, E
   Januszewicz, M
   Kala, M
   Witkowski, A
   Wiecek, A
   Narkiewicz, K
   Somers, VK
   Januszewicz, A
AF Florczak, E.
   Prejbisz, A.
   Szwench-Pietrasz, E.
   Sliwinski, P.
   Bielen, P.
   Klisiewicz, A.
   Michalowska, I.
   Warchol, E.
   Januszewicz, M.
   Kala, M.
   Witkowski, A.
   Wiecek, A.
   Narkiewicz, K.
   Somers, V. K.
   Januszewicz, A.
TI Clinical characteristics of patients with resistant hypertension: the
   RESIST-POL study
SO JOURNAL OF HUMAN HYPERTENSION
LA English
DT Article
DE resistant hypertension; obstructive sleep apnea; primary aldosteronism;
   renal artery stenosis; metabolic syndrome
ID OBSTRUCTIVE SLEEP-APNEA; PROFESSIONAL-EDUCATION-COMMITTEE;
   BLOOD-PRESSURE; PRIMARY ALDOSTERONISM; CARDIOVASCULAR-DISEASE;
   SCIENTIFIC STATEMENT; WHITE SUBJECTS; UNITED-STATES; PREVALENCE;
   ASSOCIATION
AB Recent studies indicate that resistant hypertension (RHTN) is present in about 12% of the treated hypertensive population. However, patients with true RHTN (confirmed out of the office) have not been widely studied. We prospectively studied 204 patients (123 male, 81female, mean age 48.4 years, range 19-65 years) with truly RHTN (ambulatory daytime mean blood pressure >135/85 mm Hg). We evaluated the frequency of obstructive sleep apnea (OSA), renal artery stenosis (RAS), primary aldosteronism (PA) and other secondary forms of hypertension (HTN) and conditions. Mild, moderate and severe OSA were present in 55 (27.0%), 38 (18.6%) and 54 (26.5%) patients, respectively. Secondary forms of HTN were diagnosed in 49 patients (24.0%), the most frequent being PA (15.7%) and RAS (5.4%). Metabolic syndrome (MS) was present in 65.7% of patients. Excessive sodium excretion was evident in 33.3% of patients and depression in 36.8% patients. In patients with RHTN, OSA and MS were the most frequent conditions, frequently overlapping with each other and also with PA. Our data indicate that in the vast majority of patients with truly RHTN, at least one of three co-morbidities-OSA, MS and PA-is present. Other conditions, even though less frequent, should also be taken into the consideration.
C1 [Florczak, E.; Prejbisz, A.; Szwench-Pietrasz, E.; Warchol, E.; Januszewicz, A.] Inst Cardiol, Dept Hypertens, PL-04628 Warsaw, Poland.
   [Sliwinski, P.; Bielen, P.] Inst TB & Lung Dis, Dept Resp Med 4, Warsaw, Poland.
   [Klisiewicz, A.] Inst Cardiol, Dept Congenital Heart Dis, PL-04628 Warsaw, Poland.
   [Michalowska, I.] Inst Cardiol, Dept Radiol, PL-04628 Warsaw, Poland.
   [Januszewicz, M.] Med Univ Warsaw, Dept Clin Radiol 2, Warsaw, Poland.
   [Kala, M.] Inst Forens Res, Krakow, Poland.
   [Witkowski, A.] Inst Cardiol, Dept Intervent Cardiol & Angiol, PL-04628 Warsaw, Poland.
   [Wiecek, A.] Med Univ Silesia, Dept Nephrol Endocrinol & Metab Dis, Katowice, Poland.
   [Narkiewicz, K.] Med Univ Gdansk, Dept Hypertens & Diabetol, Gdansk, Poland.
   [Somers, V. K.] Mayo Clin, Div Cardiovasc Dis, Rochester, MN USA.
   [Somers, V. K.] Mayo Clin, Div Hypertens, Rochester, MN USA.
C3 Institute of Cardiology - Poland; Institute of Cardiology - Poland;
   Institute of Cardiology - Poland; Medical University of Warsaw;
   Institute of Cardiology - Poland; Medical University of Silesia;
   Fahrenheit Universities; Medical University Gdansk; Mayo Clinic; Mayo
   Clinic
RP Prejbisz, A (corresponding author), Inst Cardiol, Dept Hypertens, Alpejska 42, PL-04628 Warsaw, Poland.
EM a.prejbisz@ikard.pl
RI Prejbisz, Aleksander/AAM-7672-2020
OI Prejbisz, Aleksander/0000-0001-7085-0244; Narkiewicz,
   Krzysztof/0000-0001-5949-5018; Januszewicz, Andrzej/0000-0002-1831-250X;
   Klisiewicz, Anna/0000-0001-5439-7443; Januszewicz,
   Magdalena/0000-0002-4725-3545
FU Ministry of Science and Higher Education [NN 402 190 335]
FX The study was supported by the Ministry of Science and Higher Education
   NN 402 190 335.
CR Acelajado MC, 2011, INT J HYPERTENS, V2011, DOI 10.4061/2011/837817
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   Born-Frontsberg E, 2009, J CLIN ENDOCR METAB, V94, P1125, DOI 10.1210/jc.2008-2116
   Calhoun DA, 2002, HYPERTENSION, V40, P892, DOI 10.1161/01.HYP.0000040261.30455.B6
   Calhoun DA, 2008, HYPERTENSION, V51, P1403, DOI 10.1161/HYPERTENSIONAHA.108.189141
   Coughlin SR, 2004, EUR HEART J, V25, P735, DOI 10.1016/j.ehj.2004.02.021
   Acelajado MC, 2012, J CLIN HYPERTENS, V14, P7, DOI 10.1111/j.1751-7176.2011.00556.x
   Daugherty SL, 2012, CIRCULATION, V125, P1635, DOI 10.1161/CIRCULATIONAHA.111.068064
   DAVIES RJO, 1990, EUR RESPIR J, V3, P509
   de la Sierra A, 2011, HYPERTENSION, V57, P898, DOI 10.1161/HYPERTENSIONAHA.110.168948
   de Mast Q, 2009, J HYPERTENS, V27, P1333, DOI 10.1097/HJH.0b013e328329bbf4
   DEVEREUX RB, 1977, CIRCULATION, V55, P613, DOI 10.1161/01.CIR.55.4.613
   Douma S, 2008, LANCET, V371, P1921, DOI 10.1016/S0140-6736(08)60834-X
   Dudenbostel T, 2012, J HUM HYPERTENS, V26, P281, DOI 10.1038/jhh.2011.47
   Egan BM, 2011, CIRCULATION, V124, P1046, DOI 10.1161/CIRCULATIONAHA.111.030189
   Eze-Nliam CM, 2010, J HYPERTENS, V28, P1785, DOI 10.1097/HJH.0b013e32833b4a6f
   Flemons WW, 1999, SLEEP, V22, P667, DOI 10.1093/sleep/22.5.667
   Friedman O, 2010, HYPERTENSION, V56, P1077, DOI 10.1161/HYPERTENSIONAHA.110.154427
   Funder JW, 2008, J CLIN ENDOCR METAB, V93, P3266, DOI 10.1210/jc.2008-0104
   Gami AS, 2004, EUR HEART J, V25, P709, DOI 10.1016/j.ehj.2004.03.008
   Gonzaga CC, 2010, J CLIN SLEEP MED, V6, P363
   Gupta AK, 2011, J HYPERTENS, V29, P2004, DOI 10.1097/HJH.0b013e32834a8a42
   Kasai T, 2012, CIRCULATION, V126, P1495, DOI 10.1161/CIRCULATIONAHA.111.070813
   Kumbhani DJ, 2013, EUR HEART J, V34, P1204, DOI 10.1093/eurheartj/ehs368
   Levey AS, 2006, ANN INTERN MED, V145, P247, DOI 10.7326/0003-4819-145-4-200608150-00004
   Lloberes P, 2010, J SLEEP RES, V19, P597, DOI 10.1111/j.1365-2869.2010.00839.x
   Mancia G, 2007, J HYPERTENS, V25, P1751, DOI 10.1097/HJH.0b013e3282f0580f
   Nieman LK, 2008, J CLIN ENDOCR METAB, V93, P1526, DOI 10.1210/jc.2008-0125
   Nishizaka MK, 2005, AM J HYPERTENS, V18, P805, DOI 10.1016/j.amjhyper.2005.01.002
   Okorodudu DO, 2010, INT J OBESITY, V34, P791, DOI 10.1038/ijo.2010.5
   Pacak K, 2007, NAT CLIN PRACT ENDOC, V3, P92, DOI 10.1038/ncpendmet0396
   Pedrosa RP, 2011, HYPERTENSION, V58, P811, DOI 10.1161/HYPERTENSIONAHA.111.179788
   Persell SD, 2011, HYPERTENSION, V57, P1076, DOI 10.1161/HYPERTENSIONAHA.111.170308
   Pimenta E, 2012, CIRCULATION, V125, P1594, DOI 10.1161/CIRCULATIONAHA.112.097345
   Polish Society of Hypertension Polish Society of Nephrology and Polish Cardiac Society, 2010, Kardiol Pol, V68, P860
   Rechtschaffen A., 1968, MANUAL STANDARDIZED
   Rossi GP, 2007, HYPERTENSION, V50, P424, DOI 10.1161/HYPERTENSIONAHA.107.091827
   Somers VK, 2008, CIRCULATION, V118, P1080, DOI [10.1161/CIRCULATIONAHA.107.189420, 10.1161/CIRCULATIONAHA.107.189375]
   Umpierrez GE, 2007, DIABETES CARE, V30, P1699, DOI 10.2337/dc07-0031
NR 39
TC 85
Z9 97
U1 0
U2 12
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0950-9240
EI 1476-5527
J9 J HUM HYPERTENS
JI J. Hum. Hypertens.
PD NOV
PY 2013
VL 27
IS 11
BP 678
EP 685
DI 10.1038/jhh.2013.32
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 235UC
UT WOS:000325745200004
PM 23698004
DA 2025-06-11
ER

PT J
AU Zadeh, ZH
   Najdegerami, EH
   Niko, M
   Nejati, V
   Gavlighi, HA
AF Zadeh, Zahra Hossein
   Najdegerami, Ebrahim H.
   Niko, Mehdi
   Nejati, Vahid
   Gavlighi, Hassan Ahmadi
TI Low-molecular weight oligosaccharides from gum tragacanth (Astragalus
   gossypinus) ameliorate nonalcoholic fatty liver disease (NAFLD) in
   Wistar male rats
SO FOOD SCIENCE & NUTRITION
LA English
DT Article
DE autophagy; fatty liver; glycemia; gum tragacanth; oligosaccharides;
   oxidative stress
ID BIOLOGICAL-ACTIVITIES; METABOLIC SYNDROME; OXIDATIVE STRESS; IN-VITRO;
   STEATOHEPATITIS; AUTOPHAGY; OBESITY; POLYSACCHARIDES; MICROBIOTA;
   INFLAMMATION
AB Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease affecting 25% of the world's population. The effects of oligosaccharides from Gum tragacanth (Astragalus gossypinus) (GT) on oxidative stress, glucose metabolism, and expression of autophagy genes were investigated in induced non-alcoholic fatty liver. Twenty-four male healthy rats were divided into four groups, Control; high-fat diet, high-fat diet+ 100mg GT oligosaccharides/kg body weight, high-fat diet + 200 mg GT oligosaccharides/kg body weight and fed with the trial diets for 70days. At the end of the experiment, the results indicated that GT oligosaccharides affected the weight gain and liver weight in NAFLD-induced rats. In addition, the results showed that the use of GT oligosaccharides significantly decreased oxidative stress, liver injury, and hyperglycemia (p<.05) and upregulated the expression of autophagy genes in NAFLD-induced rats.
C1 [Zadeh, Zahra Hossein; Najdegerami, Ebrahim H.; Nejati, Vahid] Urmia Univ, Dept Biol, Fac Sci, Orumiyeh, Iran.
   [Niko, Mehdi] Urmia Univ, Dept Pathobiol & Qual Control, Artemia & Aquaculture Res Inst, Orumiyeh, Iran.
   [Gavlighi, Hassan Ahmadi] Tarbiat Modares Univ, Dept Food Sci & Technol, Fac Agr, Tehran, Iran.
C3 Urmia University; Urmia University; Tarbiat Modares University
RP Najdegerami, EH (corresponding author), Urmia Univ, Dept Biol, Fac Sci, Orumiyeh, Iran.
EM e.geraini@urmia.ac.ir
RI Nikoo, Mehdi/AAU-4566-2020; Ahmadi Gavlighi, Hassan/E-2368-2011
OI Ahmadi Gavlighi, Hassan/0000-0001-9103-2291; Nikoo,
   Mehdi/0000-0001-7928-9588
FU Urmia University [4542]
FX Urmia University, Grant/Award Number: 4542
CR Al Mamun MA, 2019, EVID-BASED COMPL ALT, V2019, DOI 10.1155/2019/1897237
   Begriche K, 2006, MITOCHONDRION, V6, P1, DOI 10.1016/j.mito.2005.10.004
   Bellentani S, 2017, LIVER INT, V37, P81, DOI 10.1111/liv.13299
   Brunt EM, 1999, AM J GASTROENTEROL, V94, P2467, DOI 10.1111/j.1572-0241.1999.01377.x
   Carter-Kent C, 2008, AM J GASTROENTEROL, V103, P1036, DOI 10.1111/j.1572-0241.2007.01709.x
   Chang HC, 2013, PLANT FOOD HUM NUTR, V68, P18, DOI 10.1007/s11130-013-0336-2
   Chappuis E, 2017, MOLECULES, V22, DOI 10.3390/molecules22101725
   Chitapanarux T, 2009, J GASTROEN HEPATOL, V24, P1045, DOI 10.1111/j.1440-1746.2009.05865.x
   Cho WCS, 2007, CANCER LETT, V252, P43, DOI 10.1016/j.canlet.2006.12.001
   Czaja MJ, 2010, AM J PHYSIOL-CELL PH, V298, pC973, DOI 10.1152/ajpcell.00527.2009
   da Cunha NV, 2014, AM J PHYSIOL-HEART C, V306, DOI 10.1152/ajpheart.00520.2013
   Dai ZQ, 2014, J AGR FOOD CHEM, V62, P10727, DOI 10.1021/jf503510h
   Daniel H, 2014, ISME J, V8, P295, DOI 10.1038/ismej.2013.155
   de Moura FA, 2015, INT J FOOD SCI TECH, V50, P275, DOI 10.1111/ijfs.12681
   Ehara T, 2016, BRIT J NUTR, V116, P270, DOI 10.1017/S0007114516001987
   Fabbrini E, 2010, HEPATOLOGY, V51, P679, DOI 10.1002/hep.23280
   Festi D, 2014, WORLD J GASTROENTERO, V20, P16079, DOI 10.3748/wjg.v20.i43.16079
   Fu CH, 2016, J AGR FOOD CHEM, V64, P9571, DOI 10.1021/acs.jafc.6b04468
   Fu J, 2014, PHYTOTHER RES, V28, P1275, DOI 10.1002/ptr.5188
   Gavlighi HA, 2013, J AGR FOOD CHEM, V61, P1272, DOI 10.1021/jf304795f
   Gharehbagh SA, 2021, LIFE SCI, V277, DOI 10.1016/j.lfs.2021.119585
   González-Rodríguez A, 2014, CELL DEATH DIS, V5, DOI 10.1038/cddis.2014.162
   Gosling A, 2010, FOOD CHEM, V121, P307, DOI 10.1016/j.foodchem.2009.12.063
   Grundy SM, 2004, J CLIN ENDOCR METAB, V89, P2595, DOI 10.1210/jc.2004-0372
   Hao Z, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0245749
   Jiang JB, 2010, INT J RHEUM DIS, V13, P396, DOI 10.1111/j.1756-185X.2010.01555.x
   Katsiki N, 2016, METABOLISM, V65, P1109, DOI 10.1016/j.metabol.2016.05.003
   Kazankov K, 2019, NAT REV GASTRO HEPAT, V16, P145, DOI 10.1038/s41575-018-0082-x
   Khodadoostan Mahsa, 2016, Adv Biomed Res, V5, P40, DOI 10.4103/2277-9175.178785
   Kim J, 2010, MUTAT RES-FUND MOL M, V690, P12, DOI 10.1016/j.mrfmmm.2009.09.007
   Koga H, 2010, FASEB J, V24, P3052, DOI 10.1096/fj.09-144519
   Li ZP, 2003, HEPATOLOGY, V37, P343, DOI 10.1053/jhep.2003.50048
   Liu WJ, 2016, CELL MOL BIOL LETT, V21, DOI 10.1186/s11658-016-0031-z
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   Madrigal-Matute J, 2016, GASTROENTEROLOGY, V150, P328, DOI 10.1053/j.gastro.2015.09.042
   Mao YQ, 2016, HEPATIC MED-EVID RES, V8, P27, DOI 10.2147/HMER.S98120
   Marnett LJ, 1999, MUTAT RES-FUND MOL M, V424, P83, DOI 10.1016/S0027-5107(99)00010-X
   Matsuzawa N, 2007, HEPATOLOGY, V46, P1392, DOI 10.1002/hep.21874
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Morel FB, 2015, J NUTR, V145, P2052, DOI 10.3945/jn.114.204909
   Muanprasat C, 2017, PHARMACOL THERAPEUT, V170, P80, DOI 10.1016/j.pharmthera.2016.10.013
   Nasri R, 2015, CHEM-BIOL INTERACT, V242, P71, DOI 10.1016/j.cbi.2015.08.003
   Nauta AJ, 2013, CARBOHYD POLYM, V93, P263, DOI 10.1016/j.carbpol.2012.02.021
   Pan MH, 2014, MOL NUTR FOOD RES, V58, P147, DOI 10.1002/mnfr.201300522
   Pirabalouti AG, 2016, ACTA SCI POL-HORTORU, V15, P141
   Qian MY, 2019, MAR DRUGS, V17, DOI 10.3390/md17070391
   Rahman MM, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0539-x
   Roberfroid M, 2010, BRIT J NUTR, V104, pS1, DOI 10.1017/S0007114510003363
   Ryter Stefan W, 2014, Int J Cell Biol, V2014, P502676, DOI 10.1155/2014/502676
   Singh DP, 2016, INT J OBESITY, V40, P487, DOI 10.1038/ijo.2015.197
   Singh R, 2009, NATURE, V458, P1131, DOI 10.1038/nature07976
   SUN Y, 1988, CLIN CHEM, V34, P497
   Taliercio JJ, 2013, AM J KIDNEY DIS, V62, P703, DOI 10.1053/j.ajkd.2013.04.012
   Tao WJ, 2021, MAR DRUGS, V19, DOI 10.3390/md19090501
   Tao WJ, 2019, MAR DRUGS, V17, DOI 10.3390/md17110645
   Tiippana E, 2016, SCAND J PAIN, V12, P19, DOI 10.1016/j.sjpain.2016.02.008
   Wang JJ, 2015, ISME J, V9, P1, DOI 10.1038/ismej.2014.99
   Whistler R.L., 1993, Industrial Gum: Polysaccharides and Their Derivatives, V3rd, P1
   Yang L, 2010, CELL METAB, V11, P467, DOI 10.1016/j.cmet.2010.04.005
   Zhu ZY, 2017, MEDCHEMCOMM, V8, P1521, DOI 10.1039/c7md00148g
   Zou P, 2016, FOOD CHEM, V190, P1174, DOI 10.1016/j.foodchem.2015.06.076
   Zou P, 2013, MOLECULES, V18, P9933, DOI 10.3390/molecules18089933
NR 62
TC 6
Z9 6
U1 1
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2048-7177
J9 FOOD SCI NUTR
JI Food Sci. Nutr.
PD FEB
PY 2023
VL 11
IS 2
BP 765
EP 777
DI 10.1002/fsn3.3112
EA OCT 2022
PG 13
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 8Y4YY
UT WOS:000870685100001
PM 36789034
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Yisireyili, M
   Hayashi, M
   Wu, HX
   Uchida, Y
   Yamamoto, K
   Kikuchi, R
   Hamrah, MS
   Nakayama, T
   Cheng, XW
   Matsushita, T
   Nakamura, S
   Niwa, T
   Murohara, T
   Takeshita, K
AF Yisireyili, Maimaiti
   Hayashi, Motoharu
   Wu, Hongxian
   Uchida, Yasuhiro
   Yamamoto, Koji
   Kikuchi, Ryosuke
   Hamrah, Mohammad Shoaib
   Nakayama, Takayuki
   Cheng, Xian Wu
   Matsushita, Tadashi
   Nakamura, Shigeo
   Niwa, Toshimitsu
   Murohara, Toyoaki
   Takeshita, Kyosuke
TI Xanthine oxidase inhibition by febuxostat attenuates stress-induced
   hyperuricemia, glucose dysmetabolism, and prothrombotic state in mice
SO SCIENTIFIC REPORTS
LA English
DT Article
ID SERUM URIC-ACID; INSULIN-RESISTANCE; OXIDATIVE STRESS; ADIPOSE-TISSUE;
   OXIDOREDUCTASE; INFLAMMATION; GENE; ATHEROSCLEROSIS; DISEASE; CELLS
AB Chronic stress is closely linked to the metabolic syndrome, diabetes, hyperuricemia and thromboembolism, but the mechanisms remain elusive. We reported recently that stress targets visceral adipose tissue (VAT), inducing lipolysis, low-grade inflammation with production of inflammatory adipokines, metabolic derangements such as insulin resistance, and prothrombotic state. In the present study, we hypothesized the involvement of VAT xanthine oxidoreductase (XOR), a source of reactive oxygen species (ROS) and uric acid (UA) in the above processes. Restraint stress in mice resulted in upregulation of XOR and xanthine oxidase activity, accumulation of ROS in VAT as well as liver and intestine, increase in serum UA levels, upregulation of NADPH oxidase subunits and downregulation of antioxidant enzymes. Immunohistochemistry and RT-PCR analysis also showed that restraint stress induced VAT monocyte accumulation and proinflammatory adipokine production, resulting in reduced insulin sensitivity and induction of plasminogen activator inhibitor-1 and tissue factor in VAT. Treatment with febuxostat, a potent XO inhibitor, suppressed stress-induced ROS production and VAT inflammation, resulting in improvement of serum UA levels, insulin sensitivity, and prothrombotic tendency. Our results suggest that stress perturbs glucose and UA metabolism, and promotes prothrombotic status, and that XO inhibition by febuxostat might be a potential therapy for stress-related disorders.
C1 [Yisireyili, Maimaiti; Hayashi, Motoharu; Wu, Hongxian; Uchida, Yasuhiro; Hamrah, Mohammad Shoaib; Cheng, Xian Wu; Murohara, Toyoaki; Takeshita, Kyosuke] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi, Japan.
   [Kikuchi, Ryosuke; Matsushita, Tadashi; Takeshita, Kyosuke] Nagoya Univ Hosp, Dept Clin Lab, Nagoya, Aichi, Japan.
   [Yamamoto, Koji; Matsushita, Tadashi] Nagoya Univ Hosp, Dept Blood Transfus, Nagoya, Aichi, Japan.
   [Nakamura, Shigeo] Nagoya Univ Hosp, Dept Pathol, Nagoya, Aichi, Japan.
   [Nakayama, Takayuki] Aichi Med Univ Hosp, Dept Blood Transfus, Nagakute, Aichi, Japan.
   [Wu, Hongxian] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Cardiol, Sch Med, Shanghai, Peoples R China.
   [Niwa, Toshimitsu] Shubun Univ, Fac Hlth & Nutr, Ichinomiya, Aichi, Japan.
C3 Nagoya University; Nagoya University; Nagoya University; Nagoya
   University; Aichi Medical University; Shanghai Jiao Tong University
RP Takeshita, K (corresponding author), Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi, Japan.; Takeshita, K (corresponding author), Nagoya Univ Hosp, Dept Clin Lab, Nagoya, Aichi, Japan.
EM kyousuke@med.nagoya-u.ac.jp
RI Kikuchi, Ryosuke/AAX-4971-2021; Takeshita, Kyosuke/AAD-9515-2020;
   Takeshita, Kyosuke/B-7008-2012
OI Nakayama, Takayuki/0000-0003-2389-2542; Hamrah, Mohammad
   Shoaib/0000-0003-1758-8341; Takeshita, Kyosuke/0000-0002-8283-3799
FU JSPS KAKENHI [15J00397]; Kakenhi [16K15411]; Grants-in-Aid for
   Scientific Research [15J00397, 16K15411] Funding Source: KAKEN
FX We thank Dr. F.G. Issa (www.word-medex.com.au) for the careful reading
   and editing of the manuscript. Work led by K.T. is supported by a
   Grant-in-Aid for Scientific Research (Kakenhi 16K15411). M.Y. is a JSPS
   doctoral fellow overseas researcher (JSPS KAKENHI Grant Number
   15J00397).
CR Aoyama T, 2009, BIOCHEM BIOPH RES CO, V383, P216, DOI 10.1016/j.bbrc.2009.03.154
   Baldwin W, 2011, DIABETES, V60, P1258, DOI 10.2337/db10-0916
   Battelli MG, 2014, ATHEROSCLEROSIS, V237, P562, DOI 10.1016/j.atherosclerosis.2014.10.006
   BECKMAN JS, 1989, FREE RADICAL BIO MED, V6, P607, DOI 10.1016/0891-5849(89)90068-3
   Benito Manuel, 2011, Archives of Physiology and Biochemistry, V117, P96, DOI 10.3109/13813455.2011.563748
   Berk M, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-74
   Berry CE, 2004, J PHYSIOL-LONDON, V555, P589, DOI 10.1113/jphysiol.2003.055913
   Borghi C, 2015, J HYPERTENS, V33, P1729, DOI 10.1097/HJH.0000000000000701
   Boueiz A, 2008, AM J PHYSIOL-LUNG C, V294, pL830, DOI 10.1152/ajplung.00007.2008
   Cheung BMY, 2012, CURR ATHEROSCLER REP, V14, P160, DOI 10.1007/s11883-012-0227-2
   Cimmino G, 2015, J THROMB THROMBOLYS, V40, P186, DOI 10.1007/s11239-015-1199-1
   Creager MA, 2003, CIRCULATION, V108, P1527, DOI 10.1161/01.CIR.0000091257.27563.32
   Fleshner M, 2013, BRAIN BEHAV IMMUN, V27, P1, DOI 10.1016/j.bbi.2012.08.012
   Furukawa S., 2004, Journal of Clinical Investigation, V114, P1752, DOI 10.1172/JCI21625
   Han CY, 2016, DIABETES METAB J, V40, P272
   Hayashi M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0116163
   KATHER H, 1990, J CLIN INVEST, V85, P106, DOI 10.1172/JCI114399
   KATZ JL, 1972, PSYCHOSOM MED, V34, P165, DOI 10.1097/00006842-197203000-00008
   Kauppinen A, 2013, CELL SIGNAL, V25, P1939, DOI 10.1016/j.cellsig.2013.06.007
   Lima WG, 2015, BIOCHIMIE, V116, P17, DOI 10.1016/j.biochi.2015.06.025
   Maiuolo J, 2016, INT J CARDIOL, V213, P8, DOI 10.1016/j.ijcard.2015.08.109
   Miller MW, 2014, MOL PSYCHIATR, V19, P1156, DOI 10.1038/mp.2014.111
   Nomura J, 2014, SCI REP-UK, V4, DOI 10.1038/srep04554
   Pacher P, 2006, PHARMACOL REV, V58, P87, DOI 10.1124/pr.58.1.6
   Page S, 1998, BBA-GEN SUBJECTS, V1381, P191, DOI 10.1016/S0304-4165(98)00028-2
   Feoli AMP, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/587083
   Reber SO, 2007, ENDOCRINOLOGY, V148, P670, DOI 10.1210/en.2006-0983
   Ruan H, 2002, DIABETES, V51, P3176, DOI 10.2337/diabetes.51.11.3176
   Suganami T, 2005, ARTERIOSCL THROM VAS, V25, P2062, DOI 10.1161/01.ATV.0000183883.72263.13
   Takeshita K, 2004, CIRCULATION, V109, P1776, DOI 10.1161/01.CIR.0000124224.48962.32
   Takeshita K, 2014, HYPERTENS RES, V37, P490, DOI 10.1038/hr.2014.48
   Tamura Y, 2008, ARTERIOSCL THROM VAS, V28, P2195, DOI 10.1161/ATVBAHA.108.168633
   Tsushima Y, 2013, J BIOL CHEM, V288, P27138, DOI 10.1074/jbc.M113.485094
   Uchida Y, 2012, DIABETES, V61, P1552, DOI 10.2337/db11-0828
   Uetani M, 2006, OCCUP MED-OXFORD, V56, P83, DOI 10.1093/occmed/kqi178
   Wang CH, 2007, J BIOL CHEM, V282, P7991, DOI 10.1074/jbc.M700098200
   Yamamoto K, 2002, P NATL ACAD SCI USA, V99, P890, DOI 10.1073/pnas.022608799
   Yisireyili M, 2016, PSYCHONEUROENDOCRINO, V73, P186, DOI 10.1016/j.psyneuen.2016.08.004
NR 38
TC 52
Z9 62
U1 0
U2 21
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 28
PY 2017
VL 7
AR 1266
DI 10.1038/s41598-017-01366-3
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA ET4KA
UT WOS:000400247600025
PM 28455534
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ma, ZQ
   Xin, ZL
   Di, WC
   Yan, XL
   Li, XF
   Reiter, RJ
   Yang, Y
AF Ma, Zhiqiang
   Xin, Zhenlong
   Di, Wencheng
   Yan, Xiaolong
   Li, Xiaofei
   Reiter, Russel J.
   Yang, Yang
TI Melatonin and mitochondrial function during ischemia/reperfusion injury
SO CELLULAR AND MOLECULAR LIFE SCIENCES
LA English
DT Review
DE Melatonin; Mitochondria; Ischemia/reperfusion injury; Oxidative stress
ID ISCHEMIA-REPERFUSION INJURY; ENDOPLASMIC-RETICULUM STRESS; PERMEABILITY
   TRANSITION PORE; MESENCHYMAL STEM-CELLS; OXIDATIVE STRESS;
   EXPERIMENTAL-MODELS; NITROSATIVE STRESS; METABOLIC SYNDROME;
   DIABETIC-RATS; BRAIN-INJURY
AB Ischemia/reperfusion (IR) injury occurs in many organs and tissues, and contributes to morbidity and mortality worldwide. Melatonin, an endogenously produced indolamine, provides a strong defense against IR injury. Mitochondrion, an organelle for ATP production and a decider for cell fate, has been validated to be a crucial target for melatonin to exert its protection against IR injury. In this review, we first clarify the mechanisms underlying mitochondrial dysfunction during IR and melatonin's protection of mitochondria under this condition. Thereafter, special focus is placed on the protective actions of melatonin against IR injury in brain, heart, liver, and others. Finally, we explore several potential future directions of research in this area. Collectively, the information compiled here will serve as a comprehensive reference for the actions of melatonin in IR injury identified to date and will hopefully aid in the design of future research and increase the potential of melatonin as a therapeutic agent.
C1 [Ma, Zhiqiang; Reiter, Russel J.; Yang, Yang] Northwest Univ, Fac Life Sci, Minist Educ, Key Lab Resource Biol & Biotechnol Western China, 229 Taibai North Rd, Xian 710069, Shaanxi, Peoples R China.
   [Ma, Zhiqiang; Yan, Xiaolong; Li, Xiaofei] Fourth Mil Med Univ, Tangdu Hosp, Dept Thorac Surg, 1 Xinsi Rd, Xian 710038, Shaanxi, Peoples R China.
   [Xin, Zhenlong; Yang, Yang] Fourth Mil Med Univ, Dept Biomed Engn, 169 Changle West Rd, Xian 710032, Shaanxi, Peoples R China.
   [Di, Wencheng] Nanjing Univ, Med Sch, Affiliated Drum Tower Hosp, Dept Cardiol, 321 Zhongshan Rd, Nanjing 210008, Jiangsu, Peoples R China.
   [Reiter, Russel J.; Yang, Yang] UT Hlth Sci Ctr, Dept Cellular & Struct Biol, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
C3 Northwest University Xi'an; Ministry of Education - China; Air Force
   Medical University; Air Force Medical University; Nanjing University;
   University of Texas System; University of Texas Health Science Center at
   San Antonio
RP Yang, Y (corresponding author), Northwest Univ, Fac Life Sci, Minist Educ, Key Lab Resource Biol & Biotechnol Western China, 229 Taibai North Rd, Xian 710069, Shaanxi, Peoples R China.; Yang, Y (corresponding author), Fourth Mil Med Univ, Dept Biomed Engn, 169 Changle West Rd, Xian 710032, Shaanxi, Peoples R China.; Reiter, RJ (corresponding author), UT Hlth Sci Ctr, Dept Cellular & Struct Biol, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
EM reiter@uthscsa.edu; yang200214yy@163.com
RI Ma, qiang/HZK-3874-2023; Li, xiaofei/GXF-7187-2022; Reiter,
   Russel/D-3221-2009
OI Ma, Zhiqiang/0000-0002-5555-2764; Yan, Xiaolong/0000-0003-2419-9707
FU National Natural Science Foundation of China [81500263]; China
   Postdoctoral Science Foundation [2016T90973, 2015M572681]
FX This work was supported by the National Natural Science Foundation of
   China (81500263) and China Postdoctoral Science Foundation (2016T90973
   and 2015M572681).
CR Andrabi SA, 2004, FASEB J, V18, P869, DOI 10.1096/fj.03-1031fje
   Andreas M, 2011, J CARDIOVASC MAGN R, V13, DOI 10.1186/1532-429X-13-32
   Anzell AR, 2018, MOL NEUROBIOL, V55, P2547, DOI 10.1007/s12035-017-0503-9
   Berger HR, 2016, J NEUROCHEM, V136, P339, DOI 10.1111/jnc.13420
   Block H, 2012, J EXP MED, V209, P407, DOI 10.1084/jem.20111493
   Brazao V, 2017, J PINEAL RES, V63, DOI 10.1111/jpi.12409
   Bronner DN, 2015, IMMUNITY, V43, P451, DOI 10.1016/j.immuni.2015.08.008
   Brown DA, 2013, PHARMACOL THERAPEUT, V140, P258, DOI 10.1016/j.pharmthera.2013.07.005
   Cardinali DP, 2017, NEUROENDOCRINOLOGY, V104, P382, DOI 10.1159/000446543
   Carloni S, 2014, J PINEAL RES, V57, P192, DOI 10.1111/jpi.12156
   Chang CL, 2015, J PINEAL RES, V59, P206, DOI 10.1111/jpi.12251
   Chen HH, 2016, J PINEAL RES, V61, P52, DOI 10.1111/jpi.12326
   Chouchani ET, 2016, CELL METAB, V23, P254, DOI 10.1016/j.cmet.2015.12.009
   Chuang JI, 2016, J PINEAL RES, V61, P230, DOI 10.1111/jpi.12343
   Dare AJ, 2015, REDOX BIOL, V5, P163, DOI 10.1016/j.redox.2015.04.008
   Das N, 2017, J PINEAL RES, V62, DOI 10.1111/jpi.12404
   de Luxán-Delgado B, 2016, J PINEAL RES, V61, P108, DOI 10.1111/jpi.12333
   Demirtas CY, 2015, EUR REV MED PHARMACO, V19, P1915
   Deng Y, 2015, MOL NEUROBIOL, V51, P68, DOI 10.1007/s12035-014-8789-3
   Dokmeci D, 2007, ARCH TOXICOL, V81, P655, DOI 10.1007/s00204-007-0189-2
   Duan QH, 2006, J PINEAL RES, V41, P351, DOI 10.1111/j.1600-079X.2006.00374.x
   Eltzschig HK, 2011, NAT MED, V17, P1391, DOI 10.1038/nm.2507
   Ertracht O, 2014, PHARMACOL THERAPEUT, V142, P33, DOI 10.1016/j.pharmthera.2013.11.003
   Fernández A, 2015, J PINEAL RES, V59, P292, DOI 10.1111/jpi.12264
   Filho Danilo Wilhelm, 2004, Mol Aspects Med, V25, P199, DOI 10.1016/j.mam.2004.02.020
   Fischer TW, 2013, J PINEAL RES, V54, P303, DOI 10.1111/jpi.12018
   Freitas I, 2006, IN VIVO, V20, P229
   Gao L, 2016, J PINEAL RES, V61, P340, DOI 10.1111/jpi.12351
   García JA, 2015, FASEB J, V29, P3863, DOI 10.1096/fj.15-273656
   Ginsberg MD, 2016, PROG NEUROBIOL, V145, P46, DOI 10.1016/j.pneurobio.2016.09.002
   Hamada F, 2010, NEONATOLOGY, V98, P33, DOI 10.1159/000264205
   Han F, 2011, J PINEAL RES, V51, P124, DOI 10.1111/j.1600-079X.2011.00869.x
   Han F, 2011, J PINEAL RES, V50, P281, DOI 10.1111/j.1600-079X.2010.00838.x
   Han Yi-xiang, 2006, J Zhejiang Univ Sci B, V7, P142, DOI 10.1631/jzus.2006.B0142
   Hardeland R, 2015, PROG NEUROBIOL, V127, P46, DOI 10.1016/j.pneurobio.2015.02.001
   Harner M, 2011, EMBO J, V30, P3232, DOI 10.1038/emboj.2011.235
   He B, 2016, J PINEAL RES, V60, P313, DOI 10.1111/jpi.12312
   Heusch G, 2015, CIRC RES, V116, P674, DOI 10.1161/CIRCRESAHA.116.305348
   Hickie IB, 2011, LANCET, V378, P621, DOI 10.1016/S0140-6736(11)60095-0
   Hosseinzadeh A, 2016, J PINEAL RES, V61, P411, DOI 10.1111/jpi.12362
   Hu BF, 2015, J HEPATOL, V63, P855, DOI 10.1016/j.jhep.2015.05.030
   Hu J., 2017, Atmos. Chem. Phys. Discuss, V2017, P1, DOI DOI 10.1111/JPI.12368
   Hu W, 2016, BRIT J PHARMACOL, V173, P3431, DOI 10.1111/bph.13651
   Ibáñez B, 2015, J AM COLL CARDIOL, V65, P1455, DOI 10.1016/j.jacc.2015.02.032
   Jayaraman B, 2016, CRIT REV BIOCHEM MOL, V51, P379, DOI 10.1080/10409238.2016.1215406
   Jung JE, 2009, J NEUROSCI, V29, P7003, DOI 10.1523/JNEUROSCI.1110-09.2009
   Kang JW, 2016, J PINEAL RES, V60, P383, DOI 10.1111/jpi.12319
   Kanter M, 2010, EXP MOL PATHOL, V89, P314, DOI 10.1016/j.yexmp.2010.07.006
   Kaur C, 2013, J PINEAL RES, V54, P190, DOI 10.1111/jpi.12016
   Kezic A, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/2950503
   Kim SH, 2008, J PINEAL RES, V44, P165, DOI 10.1111/j.1600-079X.2007.00504.x
   Lesnefsky EJ, 2017, ANNU REV PHARMACOL, V57, P535, DOI 10.1146/annurev-pharmtox-010715-103335
   Li GH, 2016, J TRANSL MED, V14, DOI 10.1186/s12967-016-0847-3
   Li T, 2017, CELL METAB, V25, P374, DOI 10.1016/j.cmet.2016.11.005
   Li Y, 2014, ANN MED, V46, P503, DOI 10.3109/07853890.2014.934275
   Lin C, 2016, J PINEAL RES, V61, P177, DOI 10.1111/jpi.12337
   Luo SS, 2016, FREE RADICAL BIO MED, V92, P1, DOI 10.1016/j.freeradbiomed.2015.12.026
   Ma ZQ, 2016, ONCOTARGET, V7, P46768, DOI 10.18632/oncotarget.8776
   Maessen MFH, 2017, AM J PHYSIOL-REG I, V312, pR828, DOI 10.1152/ajpregu.00466.2016
   Manchester LC, 2015, J PINEAL RES, V59, P403, DOI 10.1111/jpi.12267
   Mukherjee D, 2015, J PINEAL RES, V58, P275, DOI 10.1111/jpi.12213
   Mukherjee D, 2012, J PINEAL RES, V53, P166, DOI 10.1111/j.1600-079X.2012.00984.x
   Musatov A, 2012, FREE RADICAL RES, V46, P1313, DOI 10.3109/10715762.2012.717273
   Nagai R, 2008, J PINEAL RES, V45, P271, DOI 10.1111/j.1600-079X.2008.00586.x
   Nair SM, 2011, J PINEAL RES, V51, P313, DOI 10.1111/j.1600-079X.2011.00891.x
   Nan JL, 2017, BBA-MOL CELL RES, V1864, P1260, DOI 10.1016/j.bbamcr.2017.03.006
   Nduhirabandi F, 2016, J PINEAL RES, V60, P39, DOI 10.1111/jpi.12286
   Oakes SA, 2015, ANNU REV PATHOL-MECH, V10, P173, DOI 10.1146/annurev-pathol-012513-104649
   Okatani Y, 2003, EUR J PHARMACOL, V469, P145, DOI 10.1016/S0014-2999(03)01643-1
   Okur MH, 2018, J INVEST SURG, V31, P1, DOI 10.1080/08941939.2016.1246629
   Ong SB, 2015, J MOL CELL CARDIOL, V78, P23, DOI 10.1016/j.yjmcc.2014.11.005
   Ozdemir D, 2007, INTENS CARE MED, V33, P511, DOI 10.1007/s00134-006-0492-z
   PALMER JW, 1986, AM J PHYSIOL, V250, pH741, DOI 10.1152/ajpheart.1986.250.5.H741
   Parameyong A, 2013, J PINEAL RES, V55, P313, DOI 10.1111/jpi.12078
   Park JH, 2014, J PINEAL RES, V56, P143, DOI 10.1111/jpi.12106
   Parry BL, 2008, AM J PSYCHIAT, V165, P1551, DOI 10.1176/appi.ajp.2008.08050709
   Pei HF, 2017, J PINEAL RES, V62, DOI 10.1111/jpi.12371
   Peschke E, 2015, J PINEAL RES, V59, P1, DOI 10.1111/jpi.12240
   Petrosillo G, 2006, FASEB J, V20, P269, DOI 10.1096/fj.05-4692com
   Petrosillo G, 2009, AM J PHYSIOL-HEART C, V297, pH1487, DOI 10.1152/ajpheart.00163.2009
   Preda MB, 2014, STEM CELLS, V32, P2123, DOI 10.1002/stem.1687
   Prieto-Domínguez N, 2016, J PINEAL RES, V61, P396, DOI 10.1111/jpi.12358
   Ramos E, 2017, FREE RADICAL BIO MED, V104, P32, DOI 10.1016/j.freeradbiomed.2017.01.005
   Reiter RJ, 2016, J PINEAL RES, V61, P253, DOI 10.1111/jpi.12360
   Revuelta M, 2016, BRAIN PATHOL, V26, P186, DOI 10.1111/bpa.12272
   Rodríguez-Reynoso S, 2001, J SURG RES, V100, P141, DOI 10.1006/jsre.2001.6185
   San-Miguel B, 2015, J PINEAL RES, V59, P151, DOI 10.1111/jpi.12247
   Sarkar S, 2017, EXP GERONTOL, V92, P13, DOI 10.1016/j.exger.2017.03.009
   Shanmughapriya S, 2015, MOL CELL, V60, P47, DOI 10.1016/j.molcel.2015.08.009
   Tajeddine N, 2016, BBA-GEN SUBJECTS, V1860, P1079, DOI 10.1016/j.bbagen.2016.02.013
   Tan DX, 2013, J PINEAL RES, V54, P127, DOI 10.1111/jpi.12026
   Tao RR, 2013, J PINEAL RES, V54, P271, DOI 10.1111/jpi.12009
   Venegas C, 2012, J PINEAL RES, V52, P217, DOI 10.1111/j.1600-079X.2011.00931.x
   Wakatsuki A, 2001, J PINEAL RES, V31, P167, DOI 10.1034/j.1600-079x.2001.310211.x
   Wang FW, 2015, EUR J PHARMACOL, V748, P157, DOI 10.1016/j.ejphar.2014.09.033
   Wang K, 2016, SCI REP-UK, V6, DOI 10.1038/srep37927
   Wang WZ, 2011, J SURG RES, V171, P108, DOI 10.1016/j.jss.2010.01.019
   Wang X, 2009, STROKE, V40, P1877, DOI 10.1161/STROKEAHA.108.540765
   Watanabe K, 2004, J PINEAL RES, V37, P276, DOI 10.1111/j.1600-079X.2004.00167.x
   Wu SM, 2016, J PINEAL RES, V60, P142, DOI 10.1111/jpi.12295
   Xu SC, 2016, J PINEAL RES, V60, P291, DOI 10.1111/jpi.12310
   Yang Y, 2015, J PINEAL RES, V58, P61, DOI 10.1111/jpi.12193
   Yang Y, 2013, J PINEAL RES, V55, P275, DOI 10.1111/jpi.12070
   Yip HK, 2015, J PINEAL RES, V59, P434, DOI 10.1111/jpi.12273
   Yip HK, 2013, J PINEAL RES, V54, P207, DOI 10.1111/jpi.12020
   Yu JW, 2014, CELL BIOCHEM BIOPHYS, V70, P999, DOI 10.1007/s12013-014-0009-2
   Yu LM, 2017, SCI REP-UK, V7, DOI 10.1038/srep41337
   Yu LM, 2015, J PINEAL RES, V59, P376, DOI 10.1111/jpi.12269
   Yu LM, 2014, J PINEAL RES, V57, P228, DOI 10.1111/jpi.12161
   Zephy D, 2015, DIABETES METAB SYND, V9, P127, DOI 10.1016/j.dsx.2014.09.018
   Zhang YF, 2011, J BIOCHEM, V150, P627, DOI 10.1093/jb/mvr102
   Zhou H, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.116.005328
   Zhou H, 2014, J NEUROSCI, V34, P2967, DOI 10.1523/JNEUROSCI.1948-13.2014
   Zimmerman MA, 2013, HEPATOLOGY, V58, P1766, DOI 10.1002/hep.26505
   Zong HY, 2017, AM J TRANSL RES, V9, P1139
   Zorov DB, 2014, PHYSIOL REV, V94, P909, DOI 10.1152/physrev.00026.2013
NR 116
TC 93
Z9 100
U1 1
U2 29
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1420-682X
EI 1420-9071
J9 CELL MOL LIFE SCI
JI Cell. Mol. Life Sci.
PD NOV
PY 2017
VL 74
IS 21
BP 3989
EP 3998
DI 10.1007/s00018-017-2618-6
PG 10
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA FJ5AB
UT WOS:000412754800009
PM 28795196
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hur, KY
   Lee, MS
AF Hur, Kyu Yeon
   Lee, Myung-Shik
TI New mechanisms of metformin action: Focusing on mitochondria and the gut
SO JOURNAL OF DIABETES INVESTIGATION
LA English
DT Review
DE Autophagy; Gut; Mitochondria
ID THIOREDOXIN-INTERACTING PROTEIN; GLUCAGON-LIKE PEPTIDE-1; PANCREATIC
   BETA-CELLS; DIET-INDUCED OBESITY; GLUCOSE-HOMEOSTASIS; NLRP3
   INFLAMMASOME; OXIDATIVE STRESS; ER STRESS; INSULIN-RESISTANCE; C.
   ELEGANS
AB The most well-known mechanism of metformin action, one of the most commonly prescribed antidiabetic drugs, is adenosine monophosphate-activated protein kinase activation; however, recent investigations have shown that adenosine monophosphate-activated protein kinase-independent pathways can explain some of metformin's beneficial metabolic effects as well as undesirable side-effects. Such novel pathways include induction of mitochondrial stress, inhibition of mitochondrial shuttles, alteration of intestinal microbiota, suppression of glucagon signaling, activation of autophagy, attenuation of inflammasome activation, induction of incretin receptors and reduction of terminal endoplasmic reticulum stress. Together, these studies have broadened our understanding of the mechanisms of antidiabetic agents as well as the pathogenic mechanism of diabetes itself. The results of such investigations might help to identify new target molecules and pathways for treatment of diabetes and metabolic syndrome, and could also have broad implications in diseases other than diabetes. Accordingly, new antidiabetic drugs with better efficacy and fewer adverse effects will likely result from these studies.
C1 [Hur, Kyu Yeon; Lee, Myung-Shik] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Endocrinol & Metab,Dept Med, Seoul, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center
RP Lee, MS (corresponding author), Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Endocrinol & Metab,Dept Med, Seoul, South Korea.
EM mslee0923@skku.edu
RI Lee, Myung/C-9606-2011
FU Global Research Laboratory Grant of the National Research Foundation of
   Korea [K21004000003-10A0500-00310]; Ulsan National Institute of Science
   and Technology (UNIST) [2014M3A9D8034459]
FX This work was supported by the Global Research Laboratory Grant of the
   National Research Foundation of Korea (K21004000003-10A0500-00310), and
   the Ulsan National Institute of Science and Technology (UNIST) research
   fund (2014M3A9D8034459). The authors thank Sungkab Kim (Samsung Medical
   Center, Multimedia Services Part, Chief Illustrator) for illustrating
   the figures.
CR Alhouayek M, 2012, TRENDS MOL MED, V18, P615, DOI 10.1016/j.molmed.2012.07.009
   Back SH, 2009, CELL METAB, V10, P13, DOI 10.1016/j.cmet.2009.06.002
   Bäckhed F, 2004, P NATL ACAD SCI USA, V101, P15718, DOI 10.1073/pnas.0407076101
   Bäckhed F, 2007, P NATL ACAD SCI USA, V104, P979, DOI 10.1073/pnas.0605374104
   Bailey CJ, 2008, DIABETOLOGIA, V51, P1552, DOI 10.1007/s00125-008-1053-5
   BAILEY CJ, 1994, BRIT J PHARMACOL, V112, P671, DOI 10.1111/j.1476-5381.1994.tb13128.x
   Barbato DL, 2013, CELL DEATH DIS, V4, DOI 10.1038/cddis.2013.404
   Baur JA, 2014, CELL METAB, V20, P197, DOI 10.1016/j.cmet.2014.07.013
   Buzzai M, 2007, CANCER RES, V67, P6745, DOI 10.1158/0008-5472.CAN-06-4447
   Cabreiro F, 2013, CELL, V153, P228, DOI 10.1016/j.cell.2013.02.035
   Chai TF, 2012, CELL SIGNAL, V24, P1700, DOI 10.1016/j.cellsig.2012.04.017
   Cho MH, 2014, AUTOPHAGY, V10, P1761, DOI 10.4161/auto.29647
   Derrien M, 2011, FRONT MICROBIOL, V2, DOI 10.3389/fmicb.2011.00166
   Dethlefsen L, 2008, PLOS BIOL, V6, P2383, DOI 10.1371/journal.pbio.0060280
   Egan DF, 2011, SCIENCE, V331, P456, DOI 10.1126/science.1196371
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Feuerer M, 2009, NAT MED, V15, P930, DOI 10.1038/nm.2002
   Foretz M, 2014, CELL METAB, V20, P953, DOI 10.1016/j.cmet.2014.09.018
   Foretz M, 2010, J CLIN INVEST, V120, P2355, DOI 10.1172/JCI40671
   Hardie DG, 2007, ANNU REV PHARMACOL, V47, P185, DOI 10.1146/annurev.pharmtox.47.120505.105304
   Hardie DG, 2001, BIOESSAYS, V23, P1112, DOI 10.1002/bies.10009
   Harding HP, 2003, MOL CELL, V11, P619, DOI 10.1016/S1097-2765(03)00105-9
   He CY, 2013, DIABETES, V62, P1270, DOI 10.2337/db12-0533
   He CC, 2012, NATURE, V481, P511, DOI 10.1038/nature10758
   Hildebrandt MA, 2009, GASTROENTEROLOGY, V137, P1716, DOI 10.1053/j.gastro.2009.08.042
   Hinke SA, 2007, BRIT J PHARMACOL, V150, P1031, DOI 10.1038/sj.bjp.0707189
   Hooper LV, 2012, SCIENCE, V336, P1268, DOI 10.1126/science.1223490
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Houtkooper RH, 2013, NATURE, V497, P451, DOI 10.1038/nature12188
   Inzucchi SE, 2012, DIABETES CARE, V35, P1364, DOI 10.2337/dc12-0413
   Jiang YL, 2014, INT J BIOL SCI, V10, P268, DOI 10.7150/ijbs.7929
   Kalender A, 2010, CELL METAB, V11, P390, DOI 10.1016/j.cmet.2010.03.014
   Kim DH, 2012, DIABETOLOGIA, V55, P3308, DOI 10.1007/s00125-012-2723-x
   Kim J, 2014, J CLIN INVEST, V124, P3311, DOI 10.1172/JCI69625
   Kim J, 2013, CELL, V152, P290, DOI 10.1016/j.cell.2012.12.016
   Kim J, 2011, NAT CELL BIOL, V13, P132, DOI 10.1038/ncb2152
   Kim KH, 2014, NAT REV ENDOCRINOL, V10, P322, DOI 10.1038/nrendo.2014.35
   Kim KH, 2013, BIOCHEM BIOPH RES CO, V440, P76, DOI 10.1016/j.bbrc.2013.09.026
   Kim KH, 2013, NAT MED, V19, P83, DOI 10.1038/nm.3014
   Kim MH, 2014, J ENDOCRINOL, V220, P117, DOI 10.1530/JOE-13-0381
   KLIP A, 1990, DIABETES CARE, V13, P696, DOI 10.2337/diacare.13.6.696
   Kufer TA, 2011, NAT IMMUNOL, V12, P121, DOI 10.1038/ni.1985
   Larsen CM, 2007, NEW ENGL J MED, V356, P1517, DOI 10.1056/NEJMoa065213
   Le Chatelier E, 2013, NATURE, V500, P541, DOI 10.1038/nature12506
   Lee H, 2014, APPL ENVIRON MICROB, V80, P5935, DOI 10.1128/AEM.01357-14
   Lee HM, 2013, DIABETES, V62, P194, DOI 10.2337/db12-0420
   Lerner AG, 2012, CELL METAB, V16, P250, DOI 10.1016/j.cmet.2012.07.007
   Ley RE, 2005, P NATL ACAD SCI USA, V102, P11070, DOI 10.1073/pnas.0504978102
   Lim YM, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms5934
   Liou AP, 2013, SCI TRANSL MED, V5, DOI 10.1126/scitranslmed.3005687
   Madiraju AK, 2014, NATURE, V510, P542, DOI 10.1038/nature13270
   Maida A, 2011, DIABETOLOGIA, V54, P339, DOI 10.1007/s00125-010-1937-z
   Mannucci E, 2004, DIABETES NUTR METAB, V17, P336
   Mannucci E, 2001, DIABETES CARE, V24, P489, DOI 10.2337/diacare.24.3.489
   Maratos-Flier E, 2013, NAT MED, V19, P1218, DOI 10.1038/nm.3373
   Martin-Montalvo A, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3192
   Masini M, 2009, DIABETOLOGIA, V52, P1083, DOI 10.1007/s00125-009-1347-2
   Masters SL, 2010, NAT IMMUNOL, V11, P897, DOI 10.1038/ni.1935
   Miller RA, 2013, NATURE, V494, P256, DOI 10.1038/nature11808
   Misawa T, 2013, NAT IMMUNOL, V14, P454, DOI 10.1038/ni.2550
   Mizushima N, 2011, CELL, V147, P728, DOI 10.1016/j.cell.2011.10.026
   Mouchiroud L, 2013, CELL, V154, P430, DOI 10.1016/j.cell.2013.06.016
   Mulherin AJ, 2011, ENDOCRINOLOGY, V152, P4610, DOI 10.1210/en.2011-1485
   Nakahira K, 2011, NAT IMMUNOL, V12, P222, DOI 10.1038/ni.1980
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Onken B, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0008758
   Oslowski CM, 2012, CELL METAB, V16, P265, DOI 10.1016/j.cmet.2012.07.005
   Owen MR, 2000, BIOCHEM J, V348, P607, DOI 10.1042/0264-6021:3480607
   Pearce EL, 2009, NATURE, V460, P103, DOI 10.1038/nature08097
   Petersen KF, 2003, SCIENCE, V300, P1140, DOI 10.1126/science.1082889
   Pospisilik JA, 2003, DIABETES, V52, P741, DOI 10.2337/diabetes.52.3.741
   Pyo JO, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3300
   Qin JJ, 2012, NATURE, V490, P55, DOI 10.1038/nature11450
   Scheuner D, 2005, NAT MED, V11, P757, DOI 10.1038/nm1259
   Shaked M, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0028804
   Shan MM, 2013, SCIENCE, V342, P447, DOI 10.1126/science.1237910
   Shaw RJ, 2005, SCIENCE, V310, P1642, DOI 10.1126/science.1120781
   Shi CS, 2012, NAT IMMUNOL, V13, P255, DOI 10.1038/ni.2215
   Shin NR, 2014, GUT, V63, P727, DOI 10.1136/gutjnl-2012-303839
   Singh R, 2009, NATURE, V458, P1131, DOI 10.1038/nature07976
   Song YM, 2015, AUTOPHAGY, V11, P46, DOI 10.4161/15548627.2014.984271
   Spuss A, 2012, LAB INVEST, V92, P1020
   Turnbaugh PJ, 2006, NATURE, V444, P1027, DOI 10.1038/nature05414
   Vandanmagsar B, 2011, NAT MED, V17, P179, DOI 10.1038/nm.2279
   Verfaillie T, 2012, CELL DEATH DIFFER, V19, P1880, DOI 10.1038/cdd.2012.74
   Wen HT, 2011, NAT IMMUNOL, V12, P408, DOI 10.1038/ni.2022
   Whitman WB, 1998, P NATL ACAD SCI USA, V95, P6578, DOI 10.1073/pnas.95.12.6578
   Witters LA, 2001, J CLIN INVEST, V108, P1105, DOI 10.1172/JCI14178
   Wu J, 2013, ENDOCRINE, V44, P87, DOI 10.1007/s12020-012-9826-5
   Xie ZL, 2011, DIABETES, V60, P1770, DOI 10.2337/db10-0351
   Yee C, 2014, CELL, V157, P897, DOI 10.1016/j.cell.2014.02.055
   Youm YH, 2011, ENDOCRINOLOGY, V152, P4039, DOI 10.1210/en.2011-1326
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI13505
   Zhou RB, 2010, NAT IMMUNOL, V11, P136, DOI 10.1038/ni.1831
NR 94
TC 132
Z9 141
U1 0
U2 46
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2040-1124
J9 J DIABETES INVEST
JI J. Diabetes Investig.
PD NOV
PY 2015
VL 6
IS 6
BP 600
EP 609
DI 10.1111/jdi.12328
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CU7AL
UT WOS:000363687000002
PM 26543531
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lee, TY
   Chang, HH
   Lo, WC
   Lin, HC
AF Lee, Tzung-Yan
   Chang, Hen-Hong
   Lo, Wen-Chai
   Lin, Han-Chieh
TI Alleviation of hepatic oxidative stress by Chinese herbal medicine
   Yin-Chen-Hao-Tang in obese mice with steatosis
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Article
DE oxidative stress; herbal medicine; steatosis
ID FATTY-ACID OXIDATION; INCHIN-KO-TO; INSULIN-RESISTANCE; LIVER-DISEASE;
   METABOLIC SYNDROME; ADIPOSE-TISSUE; RATS; APOPTOSIS; FIBROSIS; PROTEIN
AB Obesity is associated with a complex systemic inflammatory state that has been implicated in the development of hepatic steatosis. This study was to test the efficacy of Yin-Chen-Hao-Tang (YCHT), an agent that improves hepatic triglyceride metabolism in its ability to modulate pathways implicated in hepatic steatosis. Mice were fed with high-fat diet for fifteen weeks. The therapeutic mechanism of YCHT likely enhanced adiponectin and endothelial progenitor cells, and up-regulation of peroxisome proliferator-activated receptor gamma might be responsible for fatty liver diseases. In addition, YCHT anti-oxidative stress effect might be associated with inhibition of hepatic free fatty acid concentrations and elevation of the glutathione levels in hepatic tissues. Furthermore, YCHT action mechanisms might promote senescence marker protein-30 metabolism that increase resistance to hepatic oxidative stress. These findings suggest a novel therapeutic approach for fatty liver progression in obesity mice.
C1 [Lee, Tzung-Yan; Chang, Hen-Hong; Lo, Wen-Chai] Chang Gung Univ, Grad Inst Tradit Chinese Med, Tao Yuan 333, Taiwan.
   [Chang, Hen-Hong] Chang Gung Mem Hosp, Ctr Tradit Chinese Med, Tao Yuan, Taiwan.
   [Lin, Han-Chieh] Taipei Vet Gen Hosp, Dept Med, Div Gastroenterol, Taipei, Taiwan.
C3 Chang Gung University; Chang Gung Memorial Hospital; Taipei Veterans
   General Hospital
RP Lee, TY (corresponding author), Chang Gung Univ, Grad Inst Tradit Chinese Med, 259 Wen Hwa 1st Rd, Tao Yuan 333, Taiwan.
EM joyamen@mail.cgu.edu.tw
RI Hen Hong, Chang/ITT-2813-2023; Lin, Han/GRF-1081-2022
OI Chang, Hen-Hong/0000-0002-7840-1504
FU National Science Council, Taipei, Taiwan [NSC96-2320-B-182-021]; Chang
   Gung Memorial Hospital [CMRPD180241]
FX This work was supported by the National Science Council, Taipei, Taiwan,
   NSC96-2320-B-182-021 and CMRPD180241 supported by a Research Grant from
   the Chang Gung Memorial Hospital.
CR Angulo P, 2002, NEW ENGL J MED, V346, P1221, DOI 10.1038/nrdp.2015.80
   Bergheim I, 2003, EUR J CLIN NUTR, V57, P431, DOI 10.1038/sj.ejcn.1601557
   Clark JM, 2002, GASTROENTEROLOGY, V122, P1649, DOI 10.1053/gast.2002.33573
   Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Fruebis J, 2001, P NATL ACAD SCI USA, V98, P2005, DOI 10.1073/pnas.041591798
   Fujita T, 1999, BIOCHEM BIOPH RES CO, V254, P1, DOI 10.1006/bbrc.1998.9841
   Grundy SM, 2002, CIRCULATION, V105, P2696, DOI 10.1161/01.CIR.0000020650.86137.84
   Inao M, 2004, J HEPATOL, V41, P584, DOI 10.1016/j.jhep.2004.06.033
   Lee TY, 2007, J PHARM PHARMACOL, V59, P583, DOI 10.1211/jpp.59.4.0014
   Lee TY, 2007, J ETHNOPHARMACOL, V109, P318, DOI 10.1016/j.jep.2006.07.042
   Lee TY, 2009, MOL CELL BIOCHEM, V325, P53, DOI 10.1007/s11010-008-0019-8
   Lee TY, 2009, INT J MOL MED, V23, P477
   Lovås K, 2009, DIABETES OBES METAB, V11, P304, DOI 10.1111/j.1463-1326.2008.00958.x
   Mayerson AB, 2002, DIABETES, V51, P797, DOI 10.2337/diabetes.51.3.797
   Mohanty P, 2002, AM J CLIN NUTR, V75, P767, DOI 10.1093/ajcn/75.4.767
   Nollen EAA, 2002, J CELL SCI, V115, P2809
   Oakes ND, 2001, DIABETES, V50, P1158, DOI 10.2337/diabetes.50.5.1158
   REED DJ, 1980, ANAL BIOCHEM, V106, P55, DOI 10.1016/0003-2697(80)90118-9
   Solomon SS, 1997, HORM METAB RES, V29, P379, DOI 10.1055/s-2007-979059
   Takahashi Y, 2008, J NUTR BIOCHEM, V19, P682, DOI 10.1016/j.jnutbio.2007.09.003
   Tiikkainen M, 2004, DIABETES, V53, P2169, DOI 10.2337/diabetes.53.8.2169
   Uysal KT, 1997, NATURE, V389, P610, DOI 10.1038/39335
   Wu SY, 2009, ACTA PHARMACOL SIN, V30, P202, DOI 10.1038/aps.2008.17
   Yamamoto M, 1996, HEPATOLOGY, V23, P552
   Yamauchi T, 2001, NAT MED, V7, P941, DOI 10.1038/90984
   Yang CS, 2007, J EXP MED, V204, P583, DOI 10.1084/jem.20061849
   Zhao XY, 2009, CLIN EXP PHARMACOL P, V36, P29, DOI 10.1111/j.1440-1681.2008.05051.x
NR 28
TC 40
Z9 41
U1 1
U2 20
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD JUN
PY 2010
VL 25
IS 6
BP 837
EP 844
DI 10.3892/ijmm_00000412
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 594QB
UT WOS:000277551200002
PM 20428786
OA Bronze
DA 2025-06-11
ER

PT J
AU Alkazemi, D
   Jackson, RL
   Chan, HM
   Kubow, S
AF Alkazemi, Dalal
   Jackson, Robert L., II
   Chan, Hing Man
   Kubow, Stan
TI Increased F3-Isoprostanes in the Canadian Inuit Population
   Could Be Cardioprotective by Limiting F2-Isoprostane
   Production
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID N-3 FATTY-ACIDS; FISH-OIL; OXIDATIVE STRESS; IN-VIVO;
   CARDIOVASCULAR-DISEASE; EICOSAPENTAENOIC ACID; DOCOSAHEXAENOIC ACID;
   BIOLOGICAL-FLUIDS; OXIDANT STRESS; HEALTH SURVEY
AB Context: F-3-isoprostanes (F-3-IsoPs), derived from peroxidation of eicosapentaenoic acid (C20:5n-3), could be cardioprotective by limiting production of F-2-isoprostanes (F-2-IsoPs), a cardiovascular disease risk factor.
   Objective: The objective of the study was to determine whether the n-3-polyunsaturated (PUFA)-rich Inuit diet is associated with a lower plasma ratio of F-2-IsoPs to F-3-IsoPs.
   Design: This was a cross-sectional observational study.
   Setting: The study was conducted in 36 Canadian Arctic Inuit communities.
   Participants: Participants included a random subset (n = 233) of Inuit adults taken from a population-based survey.
   Main Outcome Measures: Plasma F-2-IsoPs and F-3-IsoPs, cardiometabolic risk factors (blood lipids, C-reactive protein, blood pressure, fasting glucose) and markers of dietary exposure (erythrocyte n-3 and n-6 PUFA, blood levels of Se, mercury, polychlorinated biphenyls) were measured.
   Results: Inuit aged 40 years old and older vs younger Inuit showed higher concentrations of plasma F-3-IsoPs and erythrocyte n-3 PUFA and lower plasma F-2-IsoPs concentrations despite having higher blood lipids, fasting glucose, systolic blood pressure, and percentage body fat. Plasma F-3-IsoPs were not associated with any cardiometabolic measures. When subjects were categorized into tertiles according to total n-3 PUFA erythrocyte concentrations, F-3-IsoPs increased with increasing tertiles, whereas the F-2-IsoP to F-3-IsoP ratio was lowest at the highest n-3 tertile. The F-2-IsoP to F-3-IsoP ratio was significantly predicted by C20:5n-3 (beta = -.365, P = .002); C20:4n-6:C20:5n-3 (beta = .056, P = .006), blood mercury (beta = -.812, P = .015), blood Se (beta = -1.95, P = .015), and smoking (beta = .745, P = .025).
   Conclusions: Plasma F-3-IsoPs were not associated with cardiometabolic risk factors previously seen with F-2-IsoPs. Higher n-3 fatty acid status was associated with lower plasma F-2-IsoPs and higher plasma F-3-IsoPs, which provides partial explanation to the cardioprotective effects of the n-3 PUFA-rich Inuit diet.
C1 [Alkazemi, Dalal; Kubow, Stan] McGill Univ, Sch Dietet & Human Nutr, 21 111 Lakeshore, Ste Anne De Bellevue, PQ H9X 3V9, Canada.
   [Alkazemi, Dalal] McGill Univ, Ctr Indigenous Peoples Nutr & Environm, 21 111 Lakeshore, Ste Anne De Bellevue, PQ H9X 3V9, Canada.
   [Alkazemi, Dalal] Kuwait Univ, Coll Life Sci, Dept Food Sci & Nutr, Safat 13060, Kuwait.
   [Jackson, Robert L., II] Vanderbilt Univ, Dept Med & Pharmacol, Nashville, TN 37232 USA.
   [Chan, Hing Man] Univ Ottawa, Ctr Adv Res Environm Genom, Ottawa, ON K1N 6N5, Canada.
C3 McGill University; McGill University; Kuwait University; Vanderbilt
   University; University of Ottawa
RP Kubow, S (corresponding author), McGill Univ, Sch Dietet & Human Nutr, 21 111 Lakeshore, Ste Anne De Bellevue, PQ H9X 3V9, Canada.
EM stan.kubow@mcgill.ca
RI Jackson, Robert/U-1061-2019; Chan, Laurie/C-4055-2014; Kubow,
   Stan/AAJ-6913-2021; Alkazemi, Dalal Usamah Zaid/E-5481-2018
OI Alkazemi, Dalal Usamah Zaid/0000-0001-9349-2144; Kubow,
   Stan/0000-0001-5831-9880; Chan, Laurie/0000-0003-4351-7483
FU Government of Canada Federal Program for International Polar Year;
   Canadian Institutes of Health Research; Canadian Foundation for
   Innovation; Canada Research Chair Program; Health Canada; Aboriginal
   Affairs, and Northern Development Canada; Government of Nunavut;
   University of Toronto; Arctic Net
FX This work was based on support by the Government of Canada Federal
   Program for International Polar Year, Canadian Institutes of Health
   Research, Canadian Foundation for Innovation, Canada Research Chair
   Program, Health Canada, Aboriginal Affairs, and Northern Development
   Canada, Government of Nunavut, University of Toronto, and Arctic Net.
CR Alkazemi D, 2012, FREE RADICAL RES, V46, P1258, DOI 10.3109/10715762.2012.702900
   Barden AE, 2004, FREE RADICAL RES, V38, P233, DOI 10.1080/10715760310001656722
   Chateau-Degat ML, 2011, CAN J CARDIOL, V26, pe190
   Cheng JWM, 2008, J ALTERN COMPLEM MED, V14, P965, DOI 10.1089/acm.2007.0765
   Davis TA, 2006, J AM CHEM SOC, V128, P14897, DOI 10.1021/ja064399o
   Dewailly E, 2001, AM J CLIN NUTR, V74, P464
   Egeland GM, 2011, CAN MED ASSOC J, V183, P1022, DOI 10.1503/cmaj.101801
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   Gao L, 2007, J BIOL CHEM, V282, P2529, DOI 10.1074/jbc.M607622200
   Gao L, 2006, J BIOL CHEM, V281, P14092, DOI 10.1074/jbc.M601035200
   Glauert HP, 2008, ENVIRON TOXICOL PHAR, V25, P247, DOI 10.1016/j.etap.2007.10.025
   Hansson P, 2015, NUTRITION, V31, P847, DOI 10.1016/j.nut.2014.12.015
   Harris WS, 1997, AM J CLIN NUTR, V66, P254, DOI 10.1093/ajcn/66.2.254
   Hong S, 2003, J BIOL CHEM, V278, P14677, DOI 10.1074/jbc.M300218200
   König A, 2005, AM J PREV MED, V29, P335, DOI 10.1016/j.amepre.2005.07.001
   Kuhnlein HV, 2004, J NUTR, V134, P1447, DOI 10.1093/jn/134.6.1447
   Lopez-Garcia E, 2004, J NUTR, V134, P1806, DOI 10.1093/jn/134.7.1806
   Mas E, 2010, FREE RADICAL RES, V44, P983, DOI 10.3109/10715762.2010.492830
   Milne GL, 2007, METHOD ENZYMOL, V433, P113, DOI 10.1016/S0076-6879(07)33006-1
   Mori TA, 2003, FREE RADICAL BIO MED, V35, P772, DOI 10.1016/S0891-5849(03)00407-6
   MORRISON WR, 1964, J LIPID RES, V5, P600
   Morrow JD, 1999, METHOD ENZYMOL, V300, P3
   Nobmann E D, 1999, Int J Circumpolar Health, V58, P254
   Park K, 2010, CURR ATHEROSCLER REP, V12, P414, DOI 10.1007/s11883-010-0138-z
   PHILLIPS DL, 1989, ARCH ENVIRON CON TOX, V18, P495, DOI 10.1007/BF01055015
   Pratico D, 1997, J PHARMACOL EXP THER, V281, P1178
   Rylander L, 2006, CHEMOSPHERE, V62, P333, DOI 10.1016/j.chemosphere.2005.04.107
   Santilli F, 2007, FREE RADICAL BIO MED, V43, P1255, DOI 10.1016/j.freeradbiomed.2007.06.017
   Santilli F, 2015, VASC PHARMACOL, V74, P23, DOI 10.1016/j.vph.2015.09.003
   Sethi S, 2002, REDOX REP, V7, P369, DOI 10.1179/135100002125001144
   Twaroski TP, 2001, BIOCHEM PHARMACOL, V62, P273, DOI 10.1016/S0006-2952(01)00668-2
   Yin HY, 2009, FREE RADICAL BIO MED, V47, P622, DOI 10.1016/j.freeradbiomed.2009.05.033
   Zhou YE, 2011, INT J CIRCUMPOL HEAL, V70, P498, DOI 10.3402/ijch.v70i5.17864
NR 33
TC 6
Z9 7
U1 0
U2 6
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD SEP
PY 2016
VL 101
IS 9
BP 3264
EP 3271
DI 10.1210/jc.2015-4096
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EG2CB
UT WOS:000390849100009
PM 27192695
OA Bronze
DA 2025-06-11
ER

PT J
AU Juratli, SM
   Janisse, J
   Schwartz, K
   Arnetz, BB
AF Juratli, Sham Maghout
   Janisse, James
   Schwartz, Kendra
   Arnetz, Bengt B.
TI Demographic and lifestyle factors associated with perceived stress in
   the primary care setting: a MetroNet study
SO FAMILY PRACTICE
LA English
DT Article
DE Family medicine; stress
ID SELF-RATED HEALTH; CHRONIC-FATIGUE-SYNDROME; MIDDLE-AGED MEN;
   SOCIOECONOMIC-STATUS; SOCIAL SUPPORT; PSYCHOLOGICAL DISTRESS; METABOLIC
   SYNDROME; WOMEN; SLEEP; NEIGHBORHOOD
AB Methods. We distributed surveys to 100 consecutive adult patients in each of four family medicine centres in metropolitan Detroit between 2006 and 2007. Hierarchical multivariable regression analyses were used to assess the relative significance of the demographic and lifestyle factors related to stress.
   Results. Of the 400 distributed surveys, 315 (78.7%) answered a minimum of 70% of the questions and were included in the analysis. The lifestyle factors [exercise, body mass index (BMI), sleep, social support, recovery or self-care skills (such as the ability to rest, relax and recuperate)] explained 39% (P < 0.001) of the variance in stress compared to 10% (P < 0.001) by the demographic factors (age, gender, race, employment, education and marital status). Stress was inversely related to sleep (P < 0.001), recovery (P < 0.001) and social support (P = 0.02) and positively to education (P < 0.001).
   Conclusions. The modifiable lifestyle factors explained significantly more of perceived stress among primary care patients than the demographic factors. Sleep and recovery had the biggest inverse relationship with stress, which suggests that they should be the primary target for assessment and intervention in patients who report stress or stress-related disorders.
C1 [Juratli, Sham Maghout; Janisse, James; Schwartz, Kendra; Arnetz, Bengt B.] Wayne State Univ, Dept Family Med & Publ Hlth Sci, Detroit, MI 48201 USA.
C3 Wayne State University
RP Juratli, SM (corresponding author), Wayne State Univ, Dept Family Med & Publ Hlth Sci, 3939 Woodward Ave, Detroit, MI 48201 USA.
EM smjuratli@med.wayne.edu
RI Arnetz, Bengt/G-1685-2011
FU Wayne State University; Skandia insurance [420393]
FX Wayne State University research start up funds and Skandia insurance, a
   member of the Old Mutual Group (420393).
CR André-Petersson L, 2007, SOC SCI MED, V64, P830, DOI 10.1016/j.socscimed.2006.10.020
   Bikson K, 2009, SOC WORK HEALTH CARE, V48, P736, DOI 10.1080/00981380902929057
   Branth S, 2007, NUTR METAB CARDIOVAS, V17, P427, DOI 10.1016/j.numecd.2006.03.001
   Chatterjee S., 2006, Regression Analysis by Example, V4th, P317, DOI DOI 10.1002/0470055464
   Demakakos P, 2008, SOC SCI MED, V67, P330, DOI 10.1016/j.socscimed.2008.03.038
   Edéll-Gustafsson UM, 2002, SCAND J CARING SCI, V16, P179, DOI 10.1046/j.1471-6712.2002.00078.x
   Flack J M, 1991, J Assoc Acad Minor Phys, V2, P143
   Fredrickson BL, 2008, J PERS SOC PSYCHOL, V95, P1045, DOI 10.1037/a0013262
   Gale CR, 2008, PSYCHOSOM MED, V70, P397, DOI 10.1097/PSY.0b013e31816a719e
   Gianaros PJ, 2010, PSYCHOSOM MED, V72, P450, DOI 10.1097/PSY.0b013e3181e1a23c
   Goodman E, 2007, J ADOLESCENT HEALTH, V41, P479, DOI 10.1016/j.jadohealth.2007.05.020
   Goodyear-Smith F, 2008, BRIT J GEN PRACT, V58, P26, DOI 10.3399/bjgp08X263785
   Goodyear-Smith F, 2009, ANN FAM MED, V7, P239, DOI 10.1370/afm.962
   Haglund MEM, 2007, DEV PSYCHOPATHOL, V19, P889, DOI 10.1017/S0954579407000430
   Haines VA, 2009, HEALTH PLACE, V15, P383, DOI 10.1016/j.healthplace.2008.01.011
   Hamilton NA, 2007, HEALTH PSYCHOL, V26, P288, DOI 10.1037/0278-6133.26.3.288
   Hasson D., 2005, International Electronic Journal of Health Education, V8, P178
   Hasson Dan, 2006, Popul Health Metr, V4, P8, DOI 10.1186/1478-7954-4-8
   Hemingway H, 2001, EUR HEART J, V22, P1082, DOI 10.1053/euhj.2000.2534
   Israel BA, 2002, HEALTH EDUC BEHAV, V29, P342, DOI 10.1177/109019810202900306
   Killgore WDS, 2008, SLEEP MED, V9, P517, DOI 10.1016/j.sleep.2007.07.003
   Kirschbaum C, 1999, PSYCHOSOM MED, V61, P154, DOI 10.1097/00006842-199903000-00006
   Lee HY, 2008, INT J NURS STUD, V45, P1042, DOI 10.1016/j.ijnurstu.2007.05.007
   LUTGENDORF SK, 1995, PSYCHOSOM MED, V57, P310, DOI 10.1097/00006842-199507000-00002
   Maghout-Juratli S, 2010, J AM BOARD FAM MED, V23, P212, DOI 10.3122/jabfm.2010.02.090132
   Martí O, 1998, INT J DEV NEUROSCI, V16, P241, DOI 10.1016/S0736-5748(98)00030-6
   Matthews KA, 2008, HEALTH PSYCHOL, V27, P576, DOI 10.1037/0278-6133.27.5.576
   McEwen BS, 2000, NEUROPSYCHOPHARMACOL, V22, P108, DOI 10.1016/S0893-133X(99)00129-3
   Mensah FK, 2008, J EPIDEMIOL COMMUN H, V62, P599, DOI 10.1136/jech.2007.065706
   Nicholson A, 2009, SOC SCI MED, V69, P519, DOI 10.1016/j.socscimed.2009.06.024
   Novati A, 2008, SLEEP, V31, P1579, DOI 10.1093/sleep/31.11.1579
   Nummela O, 2008, INT J PUBLIC HEALTH, V53, P227, DOI 10.1007/s00038-008-6117-2
   Öhlin B, 2004, EUR HEART J, V25, P867, DOI 10.1016/j.ehj.2004.03.003
   Pearson WS, 2009, INT J PUBLIC HEALTH, V54, P23, DOI 10.1007/s00038-009-0003-4
   Peisah C, 2009, AGING MENT HEALTH, V13, P300, DOI 10.1080/13607860802459831
   Pengilly JW, 2000, J CLIN PSYCHOL, V56, P813, DOI 10.1002/(SICI)1097-4679(200006)56:6<813::AID-JCLP10>3.0.CO;2-Q
   Schell E, 2008, EUR SPINE J, V17, P393, DOI 10.1007/s00586-007-0554-0
   Schulz AJ, 2008, J URBAN HEALTH, V85, P642, DOI 10.1007/s11524-008-9288-5
   Schwartz KL, 2006, J AM BOARD FAM MED, V19, P39, DOI 10.3122/jabfm.19.1.39
   Sheps DS, 2002, CIRCULATION, V105, P1780, DOI 10.1161/01.CIR.0000014491.90666.06
   Steptoe A, 2004, PSYCHONEUROENDOCRINO, V29, P593, DOI 10.1016/S0306-4530(03)00086-6
   Taylor RR, 2001, J NERV MENT DIS, V189, P709, DOI 10.1097/00005053-200110000-00008
   Van Houdenhove B, 2004, PSYCHOTHER PSYCHOSOM, V73, P267, DOI 10.1159/000078843
   Veenstra G, 2005, SOC SCI MED, V60, P2799, DOI 10.1016/j.socscimed.2004.11.013
   Veenstra G, 2000, SOC SCI MED, V50, P619, DOI 10.1016/S0277-9536(99)00307-X
   Wiholm C, 2006, EUR J PHYSIOTHER, V8, P5, DOI 10.1080/14038190500494683
   Winwood PC, 2007, J OCCUP ENVIRON MED, V49, P862, DOI 10.1097/JOM.0b013e318124a8dc
   Yang Y, 2008, SOC SCI RES, V37, P1235, DOI 10.1016/j.ssresearch.2007.07.004
NR 48
TC 9
Z9 10
U1 0
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0263-2136
EI 1460-2229
J9 FAM PRACT
JI Fam. Pr.
PD APR
PY 2011
VL 28
IS 2
BP 156
EP 162
DI 10.1093/fampra/cmq091
PG 7
WC Primary Health Care; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA 740MN
UT WOS:000288798900006
PM 21068192
DA 2025-06-11
ER

PT J
AU Zheng, YJ
   Zhu, DM
AF Zheng, Yijun
   Zhu, Duming
TI Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID OXIDATIVE STRESS; POLYMICROBIAL SEPSIS; COMBINATION THERAPY; FLUID
   RESUSCITATION; CECAL LIGATION; MURINE MODEL; INJURY; LUNG; MICE;
   INHALATION
AB Since it was proposed in 2007, molecular hydrogen therapy has been widely concerned and researched. Many animal experiments were carried out in a variety of disease fields, such as cerebral infarction, ischemia reperfusion injury, Parkinson syndrome, type 2 diabetes mellitus, metabolic syndrome, chronic kidney disease, radiation injury, chronic hepatitis, rheumatoid arthritis, stress ulcer, acute sports injuries, mitochondrial and inflammatory disease, and acute erythema skin disease and other pathological processes or diseases. Molecular hydrogen therapy is pointed out as there is protective effect for sepsis patients, too. The impact of molecular hydrogen therapy against sepsis is shown from the aspects of basic vital signs, organ functions (brain, lung, liver, kidney, small intestine, etc.), survival rate, and so forth. Molecular hydrogen therapy is able to significantly reduce the release of inflammatory factors and oxidative stress injury. Thereby it can reduce damage of various organ functions from sepsis and improve survival rate. Molecular hydrogen therapy is a prospective method against sepsis.
C1 [Zheng, Yijun; Zhu, Duming] Fudan Univ, Zhongshan Hosp, Dept Crit Care Med, Shanghai 200032, Peoples R China.
C3 Fudan University
RP Zhu, DM (corresponding author), Fudan Univ, Zhongshan Hosp, Dept Crit Care Med, Shanghai 200032, Peoples R China.
EM zhu.duming@zs-hospital.sh.cn
CR Chen HG, 2015, INT IMMUNOPHARMACOL, V28, P643, DOI 10.1016/j.intimp.2015.07.034
   Dixon BJ, 2013, MED GAS RES, V3, DOI 10.1186/2045-9912-3-10
   Li GM, 2013, J SURG RES, V181, P279, DOI 10.1016/j.jss.2012.06.058
   Liu HY, 2015, SHOCK, V43, P504, DOI 10.1097/SHK.0000000000000316
   Liu LL, 2014, BRAIN RES, V1589, P78, DOI 10.1016/j.brainres.2014.09.030
   Liu Lingling, 2014, Zhonghua Wei Zhong Bing Ji Jiu Yi Xue, V26, P629, DOI 10.3760/cma.j.issn.2095-4352.2014.09.005
   Liu W, 2014, INT J CLIN EXP MED, V7, P919
   Liu W, 2013, WORLD J GASTROENTERO, V19, P492, DOI 10.3748/wjg.v19.i4.492
   Martin GS, 2003, NEW ENGL J MED, V348, P1546, DOI 10.1056/NEJMoa022139
   Ohsawa I, 2007, NAT MED, V13, P688, DOI 10.1038/nm1577
   Russell JA, 2006, NEW ENGL J MED, V355, P1699, DOI 10.1056/NEJMra043632
   Xie KL, 2012, SHOCK, V38, P656, DOI 10.1097/SHK.0b013e3182758646
   Xie KL, 2012, SHOCK, V37, P548, DOI 10.1097/SHK.0b013e31824ddc81
   Xie KL, 2010, SHOCK, V34, P90, DOI 10.1097/SHK.0b013e3181cdc4ae
   Zhang JY, 2014, INT IMMUNOPHARMACOL, V21, P94, DOI 10.1016/j.intimp.2014.04.011
   Zhou J, 2012, J SURG RES, V178, P390, DOI 10.1016/j.jss.2012.01.041
NR 16
TC 22
Z9 27
U1 1
U2 12
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2016
VL 2016
AR 5806057
DI 10.1155/2016/5806057
PG 6
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA DQ2VY
UT WOS:000379062800001
PM 27413421
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Bradford, BJ
   Contreras, GA
AF Bradford, Barry J.
   Contreras, G. Andres
TI Adipose Tissue Inflammation: Linking Physiological Stressors to Disease
   Susceptibility
SO ANNUAL REVIEW OF ANIMAL BIOSCIENCES
LA English
DT Review
DE immunity; metabolism; homeostasis; programming; inflammation;
   endocrinology
ID REGULATORY T-CELLS; BODY-WEIGHT LOSS; DAIRY-COWS; HEAT-STRESS;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; FETAL; FAT; MACROPHAGES;
   METABOLISM
AB The study of adipose tissue (AT) is enjoying a renaissance. White, brown, and beige adipocytes are being investigated in adult animals, and the critical roles of small depots like perivascular AT are becoming clear. But the most profound revision of the AT dogma has been its cellular composition and regulation. Single-cell transcriptomic studies revealed that adipocytes comprise well under 50% of the cells in white AT, and a substantial portion of the rest are immune cells. Altering the function of AT resident leukocytes can induce or correct metabolic syndrome and, more surprisingly, alter adaptive immune responses to infection. Although the field is dominated by obesity research, conditions such as rapid lipolysis, infection, and heat stress impact AT immune dynamics as well. Recent findings in rodents lead to critical questions that should be explored in domestic livestock as potential avenues for improved animal resilience to stressors, particularly as animals age.
C1 [Bradford, Barry J.] Michigan State Univ, Dept Anim Sci, Coll Agr & Nat Resources, E Lansing, MI 48824 USA.
   [Contreras, G. Andres] Michigan State Univ, Dept Large Anim Clin Sci, Coll Vet Med, E Lansing, MI USA.
C3 Michigan State University; Michigan State University
RP Bradford, BJ (corresponding author), Michigan State Univ, Dept Anim Sci, Coll Agr & Nat Resources, E Lansing, MI 48824 USA.
EM bjbrad@msu.edu; contre28@msu.edu
RI Bradford, Barry/B-7870-2010; Contreras, G. Andres/C-7621-2012
OI Contreras, G. Andres/0000-0003-4969-2178
CR Abeyta MA, 2023, J DAIRY SCI, V106, P1441, DOI 10.3168/jds.2022-22338
   Ahmad MF, 2019, ARTERIOSCL THROM VAS, V39, P188, DOI 10.1161/ATVBAHA.118.311720
   Akter SH, 2011, J DAIRY SCI, V94, P2871, DOI 10.3168/jds.2010-3868
   Anderson EK, 2013, DIABETES, V62, P3180, DOI 10.2337/db12-1076
   Aouadi M, 2013, P NATL ACAD SCI USA, V110, P8278, DOI 10.1073/pnas.1300492110
   Aylward BA, 2019, J DAIRY SCI, V102, P3452, DOI 10.3168/jds.2018-15156
   Billon N, 2007, DEVELOPMENT, V134, P2283, DOI 10.1242/dev.002642
   Bispham J, 2003, ENDOCRINOLOGY, V144, P3575, DOI 10.1210/en.2003-0320
   Blaszczak AM, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.650768
   Bobe G, 2004, J DAIRY SCI, V87, P3105, DOI 10.3168/jds.S0022-0302(04)73446-3
   Bonnet M, 2010, ANIMAL, V4, P1093, DOI 10.1017/S1751731110000601
   Börgeson E, 2022, FRONT CELL DEV BIOL, V10, DOI 10.3389/fcell.2022.1003118
   Bornelöv S, 2018, BMC GENOMICS, V19, DOI 10.1186/s12864-018-4675-0
   Bradford BJ, 2020, ANIMAL, V14, pS144, DOI 10.1017/S1751731119003203
   Braune J, 2021, DIABETES, V70, P538, DOI 10.2337/db20-0293
   Caputa G, 2022, CELL METAB, V34, P747, DOI 10.1016/j.cmet.2022.04.008
   CASTEILLA L, 1987, AM J PHYSIOL, V252, pE627, DOI 10.1152/ajpendo.1987.252.5.E627
   Chandler TL, 2022, J DAIRY SCI, V105, P4593, DOI 10.3168/jds.2021-21226
   Chaurasia B, 2021, ANNU REV PHYSIOL, V83, P303, DOI 10.1146/annurev-physiol-031620-093815
   Chirivi M, 2022, J DAIRY SCI, V105, P842, DOI 10.3168/jds.2021-20855
   Cho DS, 2020, J CACHEXIA SARCOPENI, V11, P1351, DOI 10.1002/jcsm.12596
   Contreras GA, 2020, J DAIRY SCI, V103, P1944, DOI 10.3168/jds.2019-17256
   Contreras GA, 2016, J DAIRY SCI, V99, P10009, DOI 10.3168/jds.2016-11552
   Contreras GA, 2015, J DAIRY SCI, V98, P6176, DOI 10.3168/jds.2015-9370
   Cottam MA, 2022, NAT COMMUN, V13, DOI 10.1038/s41467-022-30646-4
   Crociati M, 2018, THERIOGENOLOGY, V114, P46, DOI 10.1016/j.theriogenology.2018.03.026
   Cruz-Pineda WD, 2022, J LEUKOCYTE BIOL, V111, P197, DOI 10.1002/JLB.2RU1220-847R
   Czech MP, 2020, MOL METAB, V34, P27, DOI 10.1016/j.molmet.2019.12.014
   Damouche A, 2015, PLOS PATHOG, V11, DOI 10.1371/journal.ppat.1005153
   De Koster J, 2018, J DAIRY SCI, V101, P7608, DOI 10.3168/jds.2017-14318
   Dechow CD, 2002, J DAIRY SCI, V85, P3062, DOI 10.3168/jds.S0022-0302(02)74393-2
   Desai M, 2011, SEMIN REPROD MED, V29, P237, DOI 10.1055/s-0031-1275517
   Deters EL, 2020, APPL ANIM SCI, V36, P183, DOI 10.15232/aas.2019-01956
   Dirandeh E, 2020, ANIMAL, V14, P1724, DOI 10.1017/S1751731120000476
   Dornbach CW, 2023, J ANIM SCI, V101, DOI 10.1093/jas/skac333
   Ebihara T, 2021, SHOCK, V56, P718, DOI 10.1097/SHK.0000000000001756
   Edwards LJ, 2005, AM J PHYSIOL-REG I, V288, pR39, DOI 10.1152/ajpregu.00127.2004
   Emont MP, 2022, NATURE, V603, P926, DOI 10.1038/s41586-022-04518-2
   Fazeli PK, 2020, MOL METAB, V42, DOI 10.1016/j.molmet.2020.101082
   Feuerer M, 2009, NAT MED, V15, P930, DOI 10.1038/nm.2002
   Flaherty SE, 2019, SCIENCE, V363, P989, DOI 10.1126/science.aaw2586
   Fricke PM, 2023, JDS COMMUN, V4, DOI 10.3168/jdsc.2022-0280
   Friedman JM, 1998, NATURE, V395, P763, DOI 10.1038/27376
   Frigo E, 2010, J DAIRY SCI, V93, P1184, DOI 10.3168/jds.2009-2313
   Froy O, 2018, ENDOCR REV, V39, P261, DOI 10.1210/er.2017-00193
   Gartung A, 2016, J BIOL CHEM, V291, P16001, DOI 10.1074/jbc.M116.725937
   Ge YL, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1065617
   GEMMELL RT, 1978, AUST J BIOL SCI, V31, P505, DOI 10.1071/BI9780505
   Gómez-Banoy N, 2019, NAT MED, V25, P1739, DOI 10.1038/s41591-019-0610-4
   Gordon CJ, 2012, J THERM BIOL, V37, P654, DOI 10.1016/j.jtherbio.2012.08.004
   Gordon JL, 2013, VET CLIN N AM-FOOD A, V29, P433, DOI 10.1016/j.cvfa.2013.03.001
   Guo JL, 2020, J MOL CELL BIOL, V12, P764, DOI 10.1093/jmcb/mjaa009
   Hajri T, 2017, J TRAUMA ACUTE CARE, V83, P507, DOI 10.1097/TA.0000000000001610
   Hall JR, 2020, ACS BIOMATER SCI ENG, V6, P433, DOI 10.1021/acsbiomaterials.9b01384
   Hammoud SH, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.707126
   Han SJ, 2017, IMMUNITY, V47, P1154, DOI 10.1016/j.immuni.2017.11.009
   Harasymowicz NS, 2021, FASEB J, V35, DOI 10.1096/fj.202001970R
   Hausman GJ, 2014, ADIPOCYTE, V3, P242, DOI 10.4161/adip.28546
   HAUSMAN GJ, 1986, J ANIM SCI, V63, P642, DOI 10.2527/jas1986.632642x
   HAUSMAN GJ, 1984, J ANIM SCI, V58, P1550, DOI 10.2527/jas1984.5861550x
   Herrero L, 2010, P NATL ACAD SCI USA, V107, P240, DOI 10.1073/pnas.0905310107
   Hersoug LG, 2018, NUTR RES REV, V31, P153, DOI [10.1017/S0954422417000269, 10.1017/s0954422417000269]
   Horst EA, 2019, J DAIRY SCI, V102, P3584, DOI 10.3168/jds.2018-15627
   Jaitin DA, 2019, CELL, V178, P686, DOI 10.1016/j.cell.2019.05.054
   Jin L, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-23560-8
   Johnson BT, 2023, JAVMA-J AM VET MED A, V261, DOI 10.2460/javma.22.11.0517
   Karisson EA, 2010, J IMMUNOL, V184, P3127, DOI 10.4049/jimmunol.0903220
   KENNEDY GC, 1953, PROC R SOC SER B-BIO, V140, P578, DOI 10.1098/rspb.1953.0009
   Kistner TM, 2022, NAT METAB, V4, P170, DOI 10.1038/s42255-022-00538-4
   Kosteli A, 2010, J CLIN INVEST, V120, P3466, DOI 10.1172/JCI42845
   Koutsari C, 2006, J LIPID RES, V47, P1643, DOI 10.1194/jlr.R600011-JLR200
   Krafsur GM, 2019, PULM CIRC, V9, DOI 10.1177/2045894018796804
   Kratz M, 2014, CELL METAB, V20, P614, DOI 10.1016/j.cmet.2014.08.010
   Leachman JR, 2022, LIFE SCI, V304, DOI 10.1016/j.lfs.2022.120718
   Li CR, 2021, CELL METAB, V33, P1610, DOI 10.1016/j.cmet.2021.06.007
   Li Y, 2022, AM J PHYSIOL-GASTR L, V322, pG346, DOI 10.1152/ajpgi.00207.2021
   Louveau I, 2016, ANIMAL, V10, P1839, DOI 10.1017/S1751731116000872
   Mann S, 2022, J DAIRY SCI, V105, P3687, DOI 10.3168/jds.2021-21215
   Mayorga EJ, 2019, ANIM FRONT, V9, P54, DOI 10.1093/af/vfy035
   McFadden JW, 2019, J DAIRY SCI, V102, P7619, DOI 10.3168/jds.2018-16095
   Meizlish ML, 2021, ANNU REV IMMUNOL, V39, P557, DOI 10.1146/annurev-immunol-061020-053734
   Meléndez DM, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0278768
   Meléndez DM, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0228492
   Michelotti TC, 2022, FRONT CELL DEV BIOL, V10, DOI 10.3389/fcell.2022.1025240
   Misumi I, 2019, CELL REP, V27, P514, DOI 10.1016/j.celrep.2019.03.030
   Moritz E, 2022, METABOLITES, V12, DOI 10.3390/metabo12070617
   Nagajyothi F, 2012, J INFECT DIS, V205, P830, DOI 10.1093/infdis/jir840
   Nam GE, 2020, DIABETES CARE, V43, P2234, DOI 10.2337/dc19-2552
   Neary JM, 2016, J VET INTERN MED, V30, P326, DOI 10.1111/jvim.13789
   Nguyen KD, 2011, NATURE, V480, P104, DOI 10.1038/nature10653
   Olagaray KE, 2020, J DAIRY SCI, V103, P11857, DOI 10.3168/jds.2020-18462
   Olefsky JM, 2010, ANNU REV PHYSIOL, V72, P219, DOI 10.1146/annurev-physiol-021909-135846
   Oliveira BM, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-58678-0
   Oliveira BM, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-39938-0
   Petrick HL, 2020, FUNCTION, V1, DOI 10.1093/function/zqaa013
   Putman AK, 2019, J DAIRY SCI, V102, P2481, DOI 10.3168/jds.2018-15158
   Putman AK, 2018, J DAIRY SCI, V101, P9350, DOI 10.3168/jds.2018-14591
   Qing H, 2020, CELL, V182, P372, DOI 10.1016/j.cell.2020.05.054
   Qu H, 2018, J ANIM SCI, V96, P975, DOI 10.1093/jas/sky022
   Qu H, 2016, J ANIM SCI, V94, P1884, DOI 10.2527/jas.2015-0084
   Reith RR, 2022, J ANIM SCI, V100, DOI 10.1093/jas/skac019
   Renner S, 2018, MOL METAB, V16, P180, DOI 10.1016/j.molmet.2018.06.015
   Richter SH, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0167652
   Rigamonti A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017637
   ROBELIN J, 1989, J DAIRY SCI, V72, P505, DOI 10.3168/jds.S0022-0302(89)79133-5
   Russo L, 2018, IMMUNOLOGY, V155, P407, DOI 10.1111/imm.13002
   Sestan M, 2018, IMMUNITY, V49, P164, DOI 10.1016/j.immuni.2018.05.005
   Shim K, 2020, WORLD J DIABETES, V11, P1, DOI 10.4239/wjd.v11.i1.1
   Shulman GI, 2014, NEW ENGL J MED, V371, P1131, DOI 10.1056/NEJMra1011035
   Sierzant K, 2019, BMC VET RES, V15, DOI 10.1186/s12917-019-2107-2
   Spalding KL, 2008, NATURE, V453, P783, DOI 10.1038/nature06902
   Surendar J, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00257
   Swartz TH, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.700278
   Tisoncik JR, 2012, MICROBIOL MOL BIOL R, V76, P16, DOI 10.1128/MMBR.05015-11
   Torchon E, 2017, ADIPOCYTE, V6, P33, DOI 10.1080/21623945.2016.1263777
   Trim WV, 2022, NAT REV IMMUNOL, V22, P371, DOI 10.1038/s41577-021-00635-7
   Trim WV, 2022, J PHYSIOL-LONDON, V600, P921, DOI 10.1113/JP280977
   Trindade S, 2016, CELL HOST MICROBE, V19, P837, DOI 10.1016/j.chom.2016.05.002
   van Straten M, 2009, J DAIRY SCI, V92, P4386, DOI 10.3168/jds.2009-2204
   Vanacker N, 2023, J DAIRY SCI, V106, P2113, DOI 10.3168/jds.2022-22309
   Vialard F, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.588387
   Vishvanath L, 2019, J CLIN INVEST, V129, P4022, DOI 10.1172/JCI129191
   Wagoner B, 2006, AM J PHYSIOL-REG I, V290, pR1557, DOI 10.1152/ajpregu.00860.2005
   Wang A, 2016, CELL, V166, P1512, DOI 10.1016/j.cell.2016.07.026
   Wang YQ, 2021, COMPUT STRUCT BIOTEC, V19, P4641, DOI 10.1016/j.csbj.2021.07.038
   Weber JM, 2011, J EXP BIOL, V214, P286, DOI 10.1242/jeb.047050
   WIJAYASINGHE MS, 1986, J DAIRY SCI, V69, P2358, DOI 10.3168/jds.S0022-0302(86)80675-0
   WRIGHT JT, 1990, J ANIM SCI, V68, P1170, DOI 10.2527/1990.6841170x
   Xu QS, 2019, J ANIM SCI, V97, P2837, DOI 10.1093/jas/skz132
   Xu YX, 2023, COMMUN BIOL, V6, DOI 10.1038/s42003-023-04523-9
   Xue YF, 2019, ANIMAL, V13, P992, DOI 10.1017/S1751731118002136
   Yang LH, 2018, REPRODUCTION, V156, P133, DOI 10.1530/REP-18-0120
   Yang YQ, 2008, ENDOCRINE, V33, P261, DOI 10.1007/s12020-008-9085-7
   Zachut M, 2017, J DAIRY SCI, V100, P3143, DOI 10.3168/jds.2016-11750
   Zachut M, 2017, J PROTEOMICS, V158, P52, DOI 10.1016/j.jprot.2017.02.011
   Zamarron BF, 2020, OBESITY, V28, P1086, DOI 10.1002/oby.22788
   Zhu QZ, 2020, MOL METAB, V39, DOI 10.1016/j.molmet.2020.101010
   Zhu QZ, 2018, NAT REV NEPHROL, V14, P105, DOI 10.1038/nrneph.2017.157
NR 138
TC 10
Z9 11
U1 2
U2 4
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 USA
SN 2165-8102
EI 2165-8110
J9 ANNU REV ANIM BIOSCI
JI Annu. Rev. Anim. Biosci.
PY 2024
VL 12
BP 261
EP 281
DI 10.1146/annurev-animal-021122-113212
PG 21
WC Agriculture, Dairy & Animal Science; Biotechnology & Applied
   Microbiology; Veterinary Sciences; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Biotechnology & Applied Microbiology; Veterinary Sciences;
   Zoology
GA MJ6O5
UT WOS:001193295300013
PM 38064480
OA hybrid
DA 2025-06-11
ER

PT J
AU Ramos, VP
   da Silva, PG
   Oliveira, PS
   Bona, NP
   Soares, MSP
   Cardoso, JD
   Hoffmann, JF
   Chaves, FC
   Schneider, A
   Spanevello, RM
   Lencina, CL
   Stefanello, FM
   Tavares, RG
AF Ramos, Vanessa Plasse
   da Silva, Pamela Goncalves
   Oliveira, Pathise Souto
   Bona, Natalia Pontes
   Pereira Soares, Mayara Sandrielly
   Cardoso, Juliane de Souza
   Hoffmann, Jessica Fernanda
   Chaves, Fabio Clasen
   Schneider, Augusto
   Spanevello, Roselia Maria
   Lencina, Claiton Leoneti
   Stefanello, Francieli Moro
   Tavares, Rejane Giacomelli
TI Hypolipidemic and anti-inflammatory properties of phenolic richButia
   odoratafruit extract: potential involvement of paraoxonase activity
SO BIOMARKERS
LA English
DT Article
DE Phenolic compounds; animal model system; cardiovascular disease
ID OXIDATIVE STRESS; LIPOPROTEIN-LIPASE; METABOLIC SYNDROME; SEED EXTRACT;
   HYPERLIPIDEMIA; ACID; BUTYRYLCHOLINESTERASE; EXPRESSION;
   ATHEROSCLEROSIS; LYMPHOCYTES
AB Aim:This study investigated the effects of polarButia odoratafruit extract on metabolic, inflammatory, and oxidative stress parameters in rats submitted to a hyperlipidaemia condition induced by tyloxapol. Methods:Animals were divided into 3 groups: saline, saline plus tyloxapol, andB. odorataextract plus tyloxapol. Animals were treated for 15 days with a saline solution orB. odoratafruit extract and after hyperlipidaemia was induced by tyloxapol. Results:Treatment withB. odorataextract reduced serum triglyceride, total cholesterol, C-reactive protein, and adenosine deaminase and butyrylcholinesterase activities when compared to the tyloxapol group. HDL-cholesterol and paraoxonase 1 activity were higher inB. odorataextract treated animals when compared to tyloxapol-treated animals. No differences were observed in hepatic oxidative stress parameters. Phenolic compounds present inB. odoratafruit extract were identified and quantified by LC-MS/MS. Conclusion:These findings indicated that phenolic richB. odorataextract has hypolipidemic and anti-inflammatory effects in hyperlipidemic rats.
C1 [Ramos, Vanessa Plasse; da Silva, Pamela Goncalves; Oliveira, Pathise Souto; Bona, Natalia Pontes; Cardoso, Juliane de Souza; Lencina, Claiton Leoneti; Stefanello, Francieli Moro; Tavares, Rejane Giacomelli] Univ Fed Pelotas, Ctr Ciencias Quim Farmaceut & Alimentos, Lab Biomarcadores, Campus Univ S-N, BR-96160000 Pelotas, RS, Brazil.
   [Pereira Soares, Mayara Sandrielly; Spanevello, Roselia Maria] Univ Fed Pelotas, Ctr Ciencias Quim Farmaceut & Alimentos, Lab Neuroquim Inflamacao & Canc, Pelotas, RS, Brazil.
   [Hoffmann, Jessica Fernanda; Chaves, Fabio Clasen] Univ Fed Pelotas, Dept Ciencia & Tecnol Agroind, Programa Posgrad Ciencia & Tecnol Alimentos, Pelotas, RS, Brazil.
   [Schneider, Augusto] Univ Fed Pelotas, Fac Nutr, Pelotas, RS, Brazil.
C3 Universidade Federal de Pelotas; Universidade Federal de Pelotas;
   Universidade Federal de Pelotas; Universidade Federal de Pelotas
RP Stefanello, FM (corresponding author), Univ Fed Pelotas, Ctr Ciencias Quim Farmaceut & Alimentos, Lab Biomarcadores, Campus Univ S-N, BR-96160000 Pelotas, RS, Brazil.
EM nessaplasse@hotmail.com; fmstefanello@gmail.com;
   tavares.rejane@gmail.com
RI Tavares, Rejane/C-1307-2010; Spanevello, Roselia/H-1610-2018; Hoffmann,
   Jessica/E-2239-2017; de Aguiar, Mayara Sandrielly/ABA-5461-2021;
   Schneider, Augusto/B-5011-2014; Chaves, Fabio/A-6390-2013
OI Schneider, Augusto/0000-0002-3410-2860; Spanevello,
   Roselia/0000-0002-5117-2000; Giacomelli Tavares,
   Rejane/0000-0002-9806-1893; Chaves, Fabio/0000-0002-5773-0800
FU SDECT-RS
FX To the research funding agencies SDECT-RS, FAPERGS, CAPES, and CNPQ (FCC
   - 457947/2014-4).
CR Ademosun A. O., 2015, Food Science and Human Wellness, V4, P80, DOI 10.1016/j.fshw.2015.05.002
   Adeneye AA, 2010, J ETHNOPHARMACOL, V130, P307, DOI 10.1016/j.jep.2010.05.009
   AEBI H, 1984, METHOD ENZYMOL, V105, P121
   Akinyemi AJ, 2016, PLANTA MED, V82, P612, DOI 10.1055/s-0042-102062
   Aksenov MY, 2001, NEUROSCI LETT, V302, P141, DOI 10.1016/S0304-3940(01)01636-6
   Alvi SS, 2017, BIOMED PHARMACOTHER, V96, P1082, DOI 10.1016/j.biopha.2017.11.116
   Amarowicz R, 2017, CURR PHARM DESIGN, V23, P2754, DOI 10.2174/1381612823666170329142936
   Argani H, 2016, SAO PAULO MED J, V134, P234, DOI 10.1590/1516-3180.2015.01702312
   Augusti PR, 2012, LIPIDS HEALTH DIS, V11, DOI 10.1186/1476-511X-11-79
   Baghdadi H. H., 2014, British Journal of Medicine and Medical Research, V4, P4382, DOI 10.9734/BJMMR/2014/11126
   Baldissera MD, 2017, N-S ARCH PHARMACOL, V390, P215, DOI 10.1007/s00210-016-1326-3
   Ben Mansour H, 2011, ANN CLIN MICROB ANTI, V10, DOI 10.1186/1476-0711-10-32
   Bertges L.C., 2011, BRAZ J MED SCI HLTH, V1, P32
   Beskow GT, 2015, FOOD CHEM, V172, P699, DOI 10.1016/j.foodchem.2014.09.111
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Braun JBS, 2018, MOL CELL BIOCHEM, V444, P63, DOI 10.1007/s11010-017-3231-6
   Browne RW, 2007, CLIN CHEM, V53, P310, DOI 10.1373/clinchem.2006.074559
   Cardoso JD, 2018, REDOX REP, V23, P41, DOI 10.1080/13510002.2017.1375709
   Castro K. F., 2012, BRAZ J VET RES ANIM, V49, P193, DOI [10.11606/issn.1678-4456.v49i3p193-201, DOI 10.11606/ISSN.1678-4456.V49I3P193-201]
   Casula M, 2012, PATIENT PREFER ADHER, V6, P805, DOI 10.2147/PPA.S29092
   Chistiakov DA, 2017, BIOCHIMIE, V132, P19, DOI 10.1016/j.biochi.2016.10.010
   da Rocha JT, 2009, J PHARM PHARMACOL, V61, P1673, DOI 10.1211/jpp/61.12.0013
   De Bona KS, 2013, INFLAMMATION, V36, P1539, DOI 10.1007/s10753-013-9697-9
   de Sousa JA, 2017, EXP MOL PATHOL, V103, P51, DOI 10.1016/j.yexmp.2017.06.009
   Ding SB, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0181666
   Ebtehaj S, 2017, CARDIOVASC DIABETOL, V16, DOI 10.1186/s12933-017-0613-8
   ELLMAN GL, 1961, BIOCHEM PHARMACOL, V7, P88, DOI 10.1016/0006-2952(61)90145-9
   Souza BSFE, 2017, BIOMED PHARMACOTHER, V90, P542, DOI 10.1016/j.biopha.2017.04.005
   Gazal M, 2015, NEUROCHEM RES, V40, P1421, DOI 10.1007/s11064-015-1610-5
   Guisti, 1984, Methods of enzymatic analysis, V2nd, P315
   Harisa GI, 2017, EUR J PHARM SCI, V96, P62, DOI 10.1016/j.ejps.2016.09.004
   Hoffmann JF, 2018, FRUITS, V73, P125, DOI 10.17660/th2018/73.2.5
   Hossain MK, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17040569
   Huang WC, 2009, IMMUNOLOGY, V128, pe275, DOI 10.1111/j.1365-2567.2008.02959.x
   Iqbal S, 2016, PAK J MED SCI, V32, P1494, DOI 10.12669/pjms.326.11274
   Khalil A, 2021, ANTIOXID REDOX SIGN, V34, P191, DOI 10.1089/ars.2019.7998
   Khamis AA, 2017, BIOMED PHARMACOTHER, V95, P1242, DOI 10.1016/j.biopha.2017.09.071
   Khlifi R, 2019, REGUL TOXICOL PHARM, V107, DOI 10.1016/j.yrtph.2019.104404
   Kim JH, 2016, INT J BIOL MACROMOL, V91, P1033, DOI 10.1016/j.ijbiomac.2016.06.069
   Kong FS, 2018, J FOOD SCI, V83, P212, DOI 10.1111/1750-3841.14004
   Kutryb-Zajac B, 2016, CARDIOVASC RES, V112, P590, DOI 10.1093/cvr/cvw203
   Limmongkon A, 2018, FOOD CHEM, V239, P569, DOI 10.1016/j.foodchem.2017.06.162
   Melvin JC, 2013, J CANCER EPIDEMIOL, V2013, DOI 10.1155/2013/823849
   MISRA HP, 1972, J BIOL CHEM, V247, P3170
   Monika P, 2015, PHYTOMEDICINE, V22, P939, DOI 10.1016/j.phymed.2015.07.001
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   Oliveira PS, 2017, BIOMED PHARMACOTHER, V92, P935, DOI 10.1016/j.biopha.2017.05.131
   Pytel E, 2017, PHARMACOL REP, V69, P150, DOI 10.1016/j.pharep.2016.09.016
   Reale M, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-19701-7
   Rodrigues R, 2014, CLIN CHIM ACTA, V433, P105, DOI 10.1016/j.cca.2014.03.002
   Rony KA, 2014, ENVIRON TOXICOL PHAR, V37, P482, DOI 10.1016/j.etap.2014.01.004
   Shokri Y, 2020, DIABETES RES CLIN PR, V161, DOI 10.1016/j.diabres.2020.108067
   Singh K., 2017, DIABETES METABOLIC S, V17, P30381
   Toppo E, 2017, CHEM-BIOL INTERACT, V269, P9, DOI 10.1016/j.cbi.2017.03.013
   Toutouzas K, 2018, J CLIN LIPIDOL, V12, P33, DOI 10.1016/j.jacl.2017.10.019
   Vanzin CS, 2015, CELL MOL NEUROBIOL, V35, P899, DOI 10.1007/s10571-015-0185-7
   Villeda-González JD, 2020, LIFE SCI, V250, DOI 10.1016/j.lfs.2020.117585
   Wedell-Neergaard AS, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0190645
   Williamson G, 2017, NUTR BULL, V42, P226, DOI 10.1111/nbu.12278
   Zivkovic AR, 2016, J INFLAMM RES, V9, P221, DOI 10.2147/JIR.S117590
   Zsíros N, 2016, CLIN BIOCHEM, V49, P862, DOI 10.1016/j.clinbiochem.2016.03.011
NR 61
TC 4
Z9 4
U1 1
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1354-750X
EI 1366-5804
J9 BIOMARKERS
JI Biomarkers
PD JUL 3
PY 2020
VL 25
IS 5
BP 417
EP 424
DI 10.1080/1354750X.2020.1781261
PG 8
WC Biotechnology & Applied Microbiology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Toxicology
GA MG1SN
UT WOS:000545812700008
PM 32519899
DA 2025-06-11
ER

PT J
AU Sell, H
   Dietze-Schroeder, D
   Eckel, J
AF Sell, Henrike
   Dietze-Schroeder, Daniela
   Eckel, Juergen
TI The adipocyte-myocyte axis in insulin resistance
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID HUMAN SKELETAL-MUSCLE; NECROSIS-FACTOR-ALPHA; KAPPA-B KINASE;
   ENDOPLASMIC-RETICULUM STRESS; WHITE ADIPOSE-TISSUE; FREE FATTY-ACIDS;
   METABOLIC SYNDROME; 3T3-L1 ADIPOCYTES; DIABETES-MELLITUS; POTENTIAL ROLE
AB Insulin resistance in skeletal muscle is linked to an elevated adipose tissue mass, as is found in obesity, but can also be observed in lipodystrophy, in which adipose tissue is greatly reduced. Adipose tissue releases endocrine and metabolic mediators and is actively involved in crosstalk with skeletal muscle, a process that precedes and underlies the development of insulin resistance in muscles. Adipokines including tumor necrosis factor alpha, interieukin-6, leptin and adiponectin influence insulin signaling in skeletal muscle. Free fatty acids, their metabolites and ectopic fat in muscle also contribute to insulin resistance. Recent research indicates inflammation, endoplasmic reticulum stress and oxidative stress could be underlying mechanisms at the center of the development of insulin resistance. Insights into the role of macrophages in adipose tissue add to the complicated interplay between adipose tissue and skeletal muscle.
C1 German Diabet Ctr, Inst Clin Biochem & Pathobiochem, Dusseldorf, Germany.
C3 Leibniz Association; Deutsches Diabetes-Zentrum (DDZ)
RP Eckel, J (corresponding author), German Diabet Ctr, Inst Clin Biochem & Pathobiochem, Dusseldorf, Germany.
EM eckel@uni-duesseldorf.de
OI Sell, Henrike/0000-0001-6323-6158; Eckel, Juergen/0000-0003-3645-5288
CR Almendro V, 2006, BBA-MOL CELL BIOL L, V1761, P37, DOI 10.1016/j.bbalip.2005.12.006
   Anderson JW, 2003, J AM COLL NUTR, V22, P331, DOI 10.1080/07315724.2003.10719316
   Arch JRS, 2005, P NUTR SOC, V64, P39, DOI 10.1079/PNS2004407
   Argilés JM, 2005, MED RES REV, V25, P49, DOI 10.1002/med.20010
   Arkan MC, 2005, NAT MED, V11, P191, DOI 10.1038/nm1185
   Assimacopoulos-Jeannet F, 2004, INT J OBESITY, V28, pS53, DOI 10.1038/sj.ijo.0802857
   Bandyopadhyay GK, 2005, DIABETES, V54, P2351, DOI 10.2337/diabetes.54.8.2351
   Belfort R, 2005, DIABETES, V54, P1640, DOI 10.2337/diabetes.54.6.1640
   Boden G, 2002, EUR J CLIN INVEST, V32, P14, DOI 10.1046/j.1365-2362.32.s3.3.x
   Bray GA, 2006, ENDOCRINE, V29, P109, DOI 10.1385/ENDO:29:1:109
   Brozinick JT, 2003, DIABETES, V52, P935, DOI 10.2337/diabetes.52.4.935
   Bruce CR, 2003, DIABETES, V52, P2338, DOI 10.2337/diabetes.52.9.2338
   Cancello R, 2005, DIABETES, V54, P2277, DOI 10.2337/diabetes.54.8.2277
   Carbó N, 2001, BBA-GEN SUBJECTS, V1526, P17, DOI 10.1016/S0304-4165(00)00188-4
   Chen BY, 2006, BIOCHEM BIOPH RES CO, V341, P549, DOI 10.1016/j.bbrc.2006.01.004
   Chinookoswong N, 1999, DIABETES, V48, P1487, DOI 10.2337/diabetes.48.7.1487
   Cohen B, 1996, SCIENCE, V274, P1185, DOI 10.1126/science.274.5290.1185
   Constant VA, 2006, DIABETOLOGIA, V49, P1402, DOI 10.1007/s00125-006-0253-0
   Coppack SW, 2005, BIOCHEM SOC T, V33, P1049, DOI 10.1042/BST20051049
   Dahlman I, 2006, DIABETES, V55, P1792, DOI 10.2337/db05-1421
   Dandona P, 2005, CIRCULATION, V111, P1448, DOI 10.1161/01.CIR.0000158483.13093.9D
   Daval M, 2006, J PHYSIOL-LONDON, V574, P55, DOI 10.1113/jphysiol.2006.111484
   Després JP, 2006, ANN MED, V38, P52, DOI 10.1080/07853890500383895
   Dietze D, 2004, INT J OBESITY, V28, P985, DOI 10.1038/sj.ijo.0802701
   Dietze D, 2002, DIABETES, V51, P2369, DOI 10.2337/diabetes.51.8.2369
   Dietze-Schroeder D, 2005, DIABETES, V54, P2003, DOI 10.2337/diabetes.54.7.2003
   Fain JN, 2004, ENDOCRINOLOGY, V145, P2273, DOI 10.1210/en.2003-1336
   Felber JP, 2002, INT J OBESITY, V26, pS39, DOI 10.1038/sj.ijo.0802126
   Finegood DT, 2003, INT J OBESITY, V27, pS4, DOI 10.1038/sj.ijo.0802490
   Frayn KN, 2005, P NUTR SOC, V64, P7, DOI 10.1079/PNS2004403
   Frost RA, 2004, AM J PHYSIOL-CELL PH, V287, pC1605, DOI 10.1152/ajpcell.00010.2004
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gao ZG, 2004, MOL ENDOCRINOL, V18, P2024, DOI 10.1210/me.2003-0383
   Gao ZG, 2002, J BIOL CHEM, V277, P48115, DOI 10.1074/jbc.M209459200
   GONG D., 2003, Current Opinion in Endocrinology, Diabetes and Obesity, V10, P115
   Goodpaster Bret H, 2002, Curr Diab Rep, V2, P216, DOI 10.1007/s11892-002-0086-2
   Graham TE, 2006, NEW ENGL J MED, V354, P2552, DOI 10.1056/NEJMoa054862
   Haasch D, 2006, BIOCHEM BIOPH RES CO, V343, P361, DOI 10.1016/j.bbrc.2006.02.177
   Hajri T, 2002, J CLIN INVEST, V109, P1381, DOI [10.1172/JCI200214596, 10.1172/JCI0214596]
   Halse R, 2001, DIABETES, V50, P1102, DOI 10.2337/diabetes.50.5.1102
   Haslam DW, 2005, LANCET, V366, P1197, DOI 10.1016/S0140-6736(05)67483-1
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Javor ED, 2005, DIABETES, V54, P1994, DOI 10.2337/diabetes.54.7.1994
   Jernås M, 2006, FASEB J, V20, P1540, DOI 10.1096/fj.05-5678fje
   Joffe BI, 2001, LANCET, V357, P1379, DOI 10.1016/S0140-6736(00)04616-X
   Kahn BB, 2000, J CLIN INVEST, V106, P473, DOI 10.1172/JCI10842
   Kanda H, 2006, J CLIN INVEST, V116, P1494, DOI 10.1172/JCI26498
   Kelley DE, 2002, DIABETES, V51, P2944, DOI 10.2337/diabetes.51.10.2944
   Kelley DE, 2002, ANNU REV NUTR, V22, P325, DOI 10.1146/annurev.nutr.22.010402.102912
   Kern PA, 2001, AM J PHYSIOL-ENDOC M, V280, pE745
   Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2548, DOI 10.1210/jc.2004-0395
   Kovacs P, 2005, BEST PRACT RES CL EN, V19, P625, DOI 10.1016/j.beem.2005.07.003
   Kralisch S, 2006, J ENDOCRINOL, V189, P665, DOI 10.1677/joe.1.06645
   Kralisch S, 2005, FEBS LETT, V579, P6417, DOI 10.1016/j.febslet.2005.10.033
   Krebs M, 2005, DIABETES OBES METAB, V7, P621, DOI 10.1111/j.1463-1326.2004.00439.x
   Lappas M, 2005, ENDOCRINOLOGY, V146, P1491, DOI 10.1210/en.2004-0809
   Lehrke M, 2004, NAT MED, V10, P126, DOI 10.1038/nm0204-126
   Lihn AS, 2005, OBES REV, V6, P13, DOI 10.1111/j.1467-789X.2005.00159.x
   Mazurek T, 2003, CIRCULATION, V108, P2460, DOI 10.1161/01.CIR.0000099542.57313.C5
   Moller DE, 2000, TRENDS ENDOCRIN MET, V11, P212, DOI 10.1016/S1043-2760(00)00272-1
   Mootha VK, 2003, NAT GENET, V34, P267, DOI 10.1038/ng1180
   Muller G, 1997, J BIOL CHEM, V272, P10585, DOI 10.1074/jbc.272.16.10585
   Muzzin P, 1996, P NATL ACAD SCI USA, V93, P14804, DOI 10.1073/pnas.93.25.14804
   Nawrocki AR, 2004, CURR OPIN PHARMACOL, V4, P281, DOI 10.1016/j.coph.2004.03.003
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Pender C, 2005, METABOLISM, V54, P598, DOI 10.1016/j.metabol.2004.11.018
   Permana PA, 2006, BIOCHEM BIOPH RES CO, V341, P507, DOI 10.1016/j.bbrc.2006.01.012
   Petersen KF, 2004, NEW ENGL J MED, V350, P664, DOI 10.1056/NEJMoa031314
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Quinn LBS, 2005, CELL BIOL INT, V29, P449, DOI 10.1016/j.cellbi.2005.02.005
   RANDLE PJ, 1963, LANCET, V1, P785
   Rieusset J, 2004, DIABETES, V53, P2232, DOI 10.2337/diabetes.53.9.2232
   Rotter V, 2003, J BIOL CHEM, V278, P45777, DOI 10.1074/jbc.M301977200
   Ruan H, 2003, CYTOKINE GROWTH F R, V14, P447, DOI 10.1016/S1359-6101(03)00052-2
   Sartipy P, 2003, P NATL ACAD SCI USA, V100, P7265, DOI 10.1073/pnas.1133870100
   Schrauwen P, 2004, DIABETES, V53, P1412, DOI 10.2337/diabetes.53.6.1412
   Sell H, 2006, ENDOCRINOLOGY, V147, P2458, DOI 10.1210/en.2005-0969
   Senn JJ, 2002, DIABETES, V51, P3391, DOI 10.2337/diabetes.51.12.3391
   Shimomura I, 1999, NATURE, V401, P73, DOI 10.1038/43448
   Shoelson SE, 2003, INT J OBESITY, V27, pS49, DOI 10.1038/sj.ijo.0802501
   Sjöholm Å, 2006, DIABETES-METAB RES, V22, P4, DOI 10.1002/dmrr.568
   Steensberg A, 2002, AM J PHYSIOL-ENDOC M, V283, pE1272, DOI 10.1152/ajpendo.00255.2002
   Sweeney G, 2001, ENDOCRINOLOGY, V142, P4806, DOI 10.1210/en.142.11.4806
   Takahashi K, 2003, J BIOL CHEM, V278, P46654, DOI 10.1074/jbc.M309895200
   Trayhurn P, 2004, BRIT J NUTR, V92, P347, DOI 10.1079/BJN20041213
   Trayhurn P, 2005, ACTA PHYSIOL SCAND, V184, P285, DOI 10.1111/j.1365-201X.2005.01468.x
   Trujillo ME, 2005, J INTERN MED, V257, P167, DOI 10.1111/j.1365-2796.2004.01426.x
   Tsalikian E, 2004, DIABETES CARE, V27, P722
   Tschritter O, 2003, DIABETES, V52, P239, DOI 10.2337/diabetes.52.2.239
   van Hall G, 2003, J CLIN ENDOCR METAB, V88, P3005, DOI 10.1210/jc.2002-021687
   Weigert C, 2005, AM J PHYSIOL-ENDOC M, V289, pE251, DOI 10.1152/ajpendo.00448.2004
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Widdowson PS, 1998, HORM METAB RES, V30, P259, DOI 10.1055/s-2007-978879
   Yang Q, 2005, NATURE, V436, P356, DOI 10.1038/nature03711
   Ye JM, 2001, DIABETES, V50, P411, DOI 10.2337/diabetes.50.2.411
   Zhang FM, 2005, VITAM HORM, V71, P345, DOI 10.1016/S0083-6729(05)71012-8
   Zhao LH, 2006, CURR OPIN CELL BIOL, V18, P444, DOI 10.1016/j.ceb.2006.06.005
   Zierath JR, 2000, DIABETOLOGIA, V43, P821, DOI 10.1007/s001250051457
NR 99
TC 94
Z9 113
U1 0
U2 16
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD DEC
PY 2006
VL 17
IS 10
BP 416
EP 422
DI 10.1016/j.tem.2006.10.010
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 119ZY
UT WOS:000243054200013
PM 17084639
DA 2025-06-11
ER

PT J
AU Berger, S
   Polotsky, VY
AF Berger, Slava
   Polotsky, Vsevolod Y.
TI Leptin and Leptin Resistance in the Pathogenesis of Obstructive Sleep
   Apnea: A Possible Link to Oxidative Stress and Cardiovascular
   Complications
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID CHRONIC INTERMITTENT HYPOXIA; POSITIVE AIRWAY PRESSURE; DIET-INDUCED
   OBESITY; SYMPATHETIC-NERVOUS-SYSTEM; RECEPTOR MESSENGER-RNA; NADPH
   OXIDASE; INSULIN-RESISTANCE; METABOLIC SYNDROME; HEART-FAILURE;
   RISK-FACTOR
AB Obesity-related sleep breathing disorders such as obstructive sleep apnea (OSA) and obesity hypoventilation syndrome (OHS) cause intermittent hypoxia (IH) during sleep, a powerful trigger of oxidative stress. Obesity also leads to dramatic increases in circulating levels of leptin, a hormone produced in adipose tissue. Leptin acts in the hypothalamus to suppress food intake and increase metabolic rate. However, obese individuals are resistant to metabolic effects of leptin. Leptin also activates the sympathetic nervous system without any evidence of resistance, possibly because these effects occur peripherally without a need to penetrate the blood-brain barrier. IH is a potent stimulator of leptin expression and release from adipose tissue. Hyperleptinemia and leptin resistance may upregulate generation of reactive oxygen species, increasing oxidative stress and promoting inflammation. The current review summarizes recent data on a possible link between leptin and oxidative stress in the pathogenesis of sleep breathing disorders.
C1 [Berger, Slava; Polotsky, Vsevolod Y.] Johns Hopkins Univ, Sch Med, Dept Med, Div Pulm & Crit Care & Sleep Med, Baltimore, MD 21205 USA.
C3 Johns Hopkins University
RP Polotsky, VY (corresponding author), Johns Hopkins Univ, Sch Med, Dept Med, Div Pulm & Crit Care & Sleep Med, Baltimore, MD 21205 USA.
EM vpolots1@jhmi.edu
RI Berger, Slava/AAF-7088-2020
OI Polotsky, Vsevolod/0000-0002-2951-7535; Berger,
   Slava/0000-0001-6188-0118
CR Aizawa-Abe M, 2000, J CLIN INVEST, V105, P1243, DOI 10.1172/JCI8341
   Amos DL, 2017, BBA-MOL BASIS DIS, V1863, P2293, DOI 10.1016/j.bbadis.2017.06.016
   Arnardottir ES, 2013, INT J OBESITY, V37, P835, DOI 10.1038/ijo.2012.138
   Asferg C, 2010, AM J HYPERTENS, V23, P327, DOI 10.1038/ajh.2009.244
   Bado A, 1998, NATURE, V394, P790, DOI 10.1038/29547
   Banks WA, 1996, PEPTIDES, V17, P305, DOI 10.1016/0196-9781(96)00025-3
   Bjorbaek C, 1997, J BIOL CHEM, V272, P32686, DOI 10.1074/jbc.272.51.32686
   Blanca AJ, 2016, J CELL BIOCHEM, V117, P2281, DOI 10.1002/jcb.25526
   Bonomini F, 2015, AGING DIS, V6, P109, DOI 10.14336/AD.2014.0305
   Briançon-Marjollet A, 2016, EXP PHYSIOL, V101, P1432, DOI 10.1113/EP085783
   Caldefie-Chezet F, 2001, J LEUKOCYTE BIOL, V69, P414
   Carpagnano GE, 2003, CHEST, V124, P1386, DOI 10.1378/chest.124.4.1386
   Ciriello J, 2016, NEUROSCI LETT, V626, P112, DOI 10.1016/j.neulet.2016.05.029
   Considine RV, 1996, NEW ENGL J MED, V334, P292, DOI 10.1056/NEJM199602013340503
   Çuhadaroglu Ç, 2009, LUNG, V187, P75, DOI 10.1007/s00408-008-9131-5
   CULEBRAS A, 2012, SLEEP STROKE CARDIOV
   de Git KCG, 2015, OBES REV, V16, P207, DOI 10.1111/obr.12243
   Denroche HC, 2012, J DIABETES INVEST, V3, P115, DOI 10.1111/j.2040-1124.2012.00203.x
   Dewan NA, 2015, CHEST, V147, P266, DOI 10.1378/chest.14-0500
   Ding YF, 2010, AM J PHYSIOL-REG I, V298, pR303, DOI 10.1152/ajpregu.00629.2009
   Dong F, 2006, HYPERTENSION, V47, P222, DOI 10.1161/01.HYP.0000198555.51645.f1
   Drager LF, 2013, J AM COLL CARDIOL, V62, P569, DOI 10.1016/j.jacc.2013.05.045
   Eisele HJ, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/608438
   Fantuzzi G, 2000, J LEUKOCYTE BIOL, V68, P437
   Flier Jeffrey S, 2012, Yale J Biol Med, V85, P405
   Fortuño A, 2010, J HYPERTENS, V28, P1944, DOI 10.1097/HJH.0b013e32833c21af
   Frühbeck G, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-02848-0
   Fu CP, 2015, SLEEP BREATH, V19, P1467, DOI 10.1007/s11325-015-1144-8
   Gajewski Michal, 2016, Reumatologia (Warsaw), V54, P103, DOI 10.5114/reum.2016.61209
   GASTAUT H., 1966, BRAIN RES, V1, P167, DOI 10.1016/0006-8993(66)90117-X
   Gilmartin GS, 2010, AM J PHYSIOL-HEART C, V299, pH925, DOI 10.1152/ajpheart.00253.2009
   Grosfeld A, 2002, DIABETOLOGIA, V45, P527, DOI 10.1007/s00125-002-0804-y
   Hall JE, 2001, AM J HYPERTENS, V14, p103S, DOI 10.1016/S0895-7061(01)02077-5
   Hall JE, 2010, J BIOL CHEM, V285, P17271, DOI 10.1074/jbc.R110.113175
   Harsch IA, 2003, EUR RESPIR J, V22, P251, DOI 10.1183/09031936.03.00010103
   Hoggard N, 1997, P NATL ACAD SCI USA, V94, P11073, DOI 10.1073/pnas.94.20.11073
   Humphreys M., 2014, SURG OBES RELAT DIS, V10, P71
   Imayama I, 2017, ANN AM THORAC SOC, V14, P1607, DOI 10.1513/AnnalsATS.201702-181FR
   Jamar G, 2017, APPETITE, V108, P477, DOI 10.1016/j.appet.2016.11.013
   Jéquier E, 2002, ANN NY ACAD SCI, V967, P379, DOI 10.1111/j.1749-6632.2002.tb04293.x
   Kim S, 2002, J NUTR, V132, P1135, DOI 10.1093/jn/132.6.1135
   Koh KK, 2008, CIRCULATION, V117, P3238, DOI 10.1161/CIRCULATIONAHA.107.741645
   Lavie L, 2003, SLEEP MED REV, V7, P35, DOI 10.1053/smrv.2002.0261
   Lavie L, 2007, SLEEP BIOL RHYTHMS, V5, P100, DOI 10.1111/j.1479-8425.2007.00259.x
   Lavie L, 2015, SLEEP MED REV, V20, P27, DOI 10.1016/j.smrv.2014.07.003
   Lavie L, 2009, PROG CARDIOVASC DIS, V51, P303, DOI 10.1016/j.pcad.2008.08.003
   Lin CC, 2014, ANN OTO RHINOL LARYN, V123, P40, DOI 10.1177/0003489414521385
   Lin Y, 2007, SCI CHINA SER C, V50, P669, DOI 10.1007/s11427-007-0077-2
   Malli F, 2010, RESP RES, V11, DOI 10.1186/1465-9921-11-152
   Marin JM, 2005, LANCET, V365, P1046, DOI 10.1016/S0140-6736(05)71141-7
   Marshall NS, 2008, SLEEP, V31, P1079
   Matsuda M, 2013, OBES RES CLIN PRACT, V7, pE330, DOI 10.1016/j.orcp.2013.05.004
   McMurray F, 2016, OBESITY, V24, P2301, DOI 10.1002/oby.21654
   Meister B, 2001, CLIN EXP PHARMACOL P, V28, P610, DOI 10.1046/j.1440-1681.2001.03493.x
   Mela V, 2017, MOL CELL ENDOCRINOL, V454, P125, DOI 10.1016/j.mce.2017.06.018
   Mercer JG, 1996, FEBS LETT, V387, P113, DOI 10.1016/0014-5793(96)00473-5
   Minokoshi Y, 2002, NATURE, V415, P339, DOI 10.1038/415339a
   Morawietz H, 2006, HYPERTENSION, V47, pE20, DOI 10.1161/01.HYP.0000218452.18010.fb
   Moschos S, 2002, FERTIL STERIL, V77, P433, DOI 10.1016/S0015-0282(01)03010-2
   Myers MG, 2008, ANNU REV PHYSIOL, V70, P537, DOI 10.1146/annurev.physiol.70.113006.100707
   Nieto FJ, 2012, AM J RESP CRIT CARE, V186, P190, DOI 10.1164/rccm.201201-0130OC
   Olea E, 2014, J APPL PHYSIOL, V117, P706, DOI 10.1152/japplphysiol.00454.2014
   Ostlund RE, 1996, J CLIN ENDOCR METAB, V81, P3909, DOI 10.1210/jc.81.11.3909
   Öztürk L, 2003, ARCH OTOLARYNGOL, V129, P538, DOI 10.1001/archotol.129.5.538
   Pan WH, 2014, SLEEP MED REV, V18, P283, DOI 10.1016/j.smrv.2013.07.003
   Pedersen SD, 2013, GASTROENT RES PRACT, V2013, DOI 10.1155/2013/528450
   Peppard PE, 2013, AM J EPIDEMIOL, V177, P1006, DOI 10.1093/aje/kws342
   Phillips BG, 2000, AM J PHYSIOL-HEART C, V279, pH234, DOI 10.1152/ajpheart.2000.279.1.H234
   Phipps PR, 2002, THORAX, V57, P75, DOI 10.1136/thorax.57.1.75
   Pho H, 2016, J APPL PHYSIOL, V120, P78, DOI 10.1152/japplphysiol.00494.2015
   Polotsky M, 2012, J APPL PHYSIOL, V112, P1637, DOI 10.1152/japplphysiol.01222.2011
   Polotsky VY, 2003, J PHYSIOL-LONDON, V552, P253, DOI 10.1113/jphysiol.2003.048173
   Porzionato A, 2011, BRAIN RES, V1385, P56, DOI 10.1016/j.brainres.2011.02.028
   Punjabi NM, 2009, PLOS MED, V6, DOI 10.1371/journal.pmed.1000132
   Rahmouni K, 2005, DIABETES, V54, P2012, DOI 10.2337/diabetes.54.7.2012
   Redline S, 2007, AM J RESP CRIT CARE, V176, P401, DOI 10.1164/rccm.200703-375OC
   Reinke C, 2011, J APPL PHYSIOL, V111, P881, DOI 10.1152/japplphysiol.00492.2011
   REMMERS JE, 1978, J APPL PHYSIOL, V44, P931, DOI 10.1152/jappl.1978.44.6.931
   Reuter S, 2010, FREE RADICAL BIO MED, V49, P1603, DOI 10.1016/j.freeradbiomed.2010.09.006
   Schroeter MR, 2013, CARDIOVASC RES, V99, P555, DOI 10.1093/cvr/cvt126
   Schwartz MW, 1996, NAT MED, V2, P589, DOI 10.1038/nm0596-589
   Sforza E, 2016, HYPOXIA, V4, P99, DOI 10.2147/HP.S103091
   Shankar A, 2010, HYPERTENSION, V56, P623, DOI 10.1161/HYPERTENSIONAHA.109.148213
   Shapiro SD, 2014, J APPL PHYSIOL, V116, P1334, DOI 10.1152/japplphysiol.00958.2013
   Sies H, 2015, REDOX BIOL, V4, P180, DOI 10.1016/j.redox.2015.01.002
   Simonds SE, 2013, TRENDS NEUROSCI, V36, P121, DOI 10.1016/j.tins.2013.01.004
   Singh M, 2010, INT J CARDIOL, V140, P266, DOI 10.1016/j.ijcard.2009.07.019
   Sinha MK, 1996, J CLIN INVEST, V98, P1277, DOI 10.1172/JCI118913
   Sögüt A, 2016, TUBERK TORAK, V64, P283, DOI 10.5578/tt.21009
   Srivastava KK, 2015, INDIAN J CLIN BIOCHE, V30, P3, DOI 10.1007/s12291-014-0441-5
   Tam CS, 2011, EXPERT OPIN BIOL TH, V11, P1677, DOI 10.1517/14712598.2011.619974
   Tankersley C, 1996, J APPL PHYSIOL, V81, P716, DOI 10.1152/jappl.1996.81.2.716
   Trevaskis JL, 2016, OBES SCI PRACT, V2, P385, DOI 10.1002/osp4.62
   Upadhyay J, 2015, METABOLISM, V64, P105, DOI 10.1016/j.metabol.2014.10.021
   Van Eyck A, 2017, SLEEP MED, V30, P52, DOI 10.1016/j.sleep.2015.11.014
   Verhulst SL, 2007, J PEDIATR-US, V150, P608, DOI 10.1016/j.jpeds.2007.01.051
   Verhulst SL, 2008, SLEEP MED REV, V12, P339, DOI 10.1016/j.smrv.2007.11.002
   Verhulst SL, 2009, SLEEP BREATH, V13, P207, DOI 10.1007/s11325-008-0231-5
   Yagishita Y, 2017, CELL REP, V18, P2030, DOI 10.1016/j.celrep.2017.01.064
   Yamagishi SI, 2003, MICROVASC RES, V65, P186, DOI 10.1016/S0026-2862(03)00005-0
   Yang RH, 2007, CIRC RES, V101, P545, DOI 10.1161/CIRCRESAHA.107.156596
   Yao QL, 2016, SLEEP, V39, P1097, DOI 10.5665/sleep.5762
   Ye J, 2009, INT J OBESITY, V33, P54, DOI 10.1038/ijo.2008.229
   Yosunkaya S, 2015, METAB SYNDR RELAT D, V13, P272, DOI 10.1089/met.2014.0161
   Young T, 2008, SLEEP, V31, P1071
   ZHANG YY, 1994, NATURE, V372, P425, DOI 10.1038/372425a0
NR 106
TC 82
Z9 85
U1 0
U2 11
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2018
VL 2018
AR 5137947
DI 10.1155/2018/5137947
PG 8
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA FX1SJ
UT WOS:000425831800001
PM 29675134
OA Green Submitted, hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Sztretye, M
   Dienes, B
   Gönczi, M
   Czirják, T
   Csernoch, L
   Dux, L
   Szentesi, P
   Keller-Pintér, A
AF Sztretye, Monika
   Dienes, Beatrix
   Gonczi, Monika
   Czirjak, Tamas
   Csernoch, Laszlo
   Dux, Laszlo
   Szentesi, Peter
   Keller-Pinter, Aniko
TI Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in
   Diseases and with Aging
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID INSULIN-RECEPTOR SUBSTRATE-1; INDUCED OXIDATIVE STRESS; DISUSE MUSCLE
   ATROPHY; SKELETAL-MUSCLE; LIPID-METABOLISM; UP-REGULATION; CAROTENOID
   ASTAXANTHIN; SARCOPLASMIC-RETICULUM; CAPILLARY REGRESSION;
   GLUCOSE-METABOLISM
AB Oxidative stress is characterized by an imbalance between prooxidant and antioxidant species, leading to macromolecular damage and disruption of redox signaling and cellular control. It is a hallmark of various diseases including metabolic syndrome, chronic fatigue syndrome, neurodegenerative, cardiovascular, inflammatory, and age-related diseases. Several mitochondrial defects have been considered to contribute to the development of oxidative stress and known as the major mediators of the aging process and subsequent age-associated diseases. Thus, mitochondrial-targeted antioxidants should prevent or slow down these processes and prolong longevity. This is the reason why antioxidant treatments are extensively studied and newer and newer compounds with such an effect appear. Astaxanthin, a xanthophyll carotenoid, is the most abundant carotenoid in marine organisms and is one of the most powerful natural compounds with remarkable antioxidant activity. Here, we summarize its antioxidant targets, effects, and benefits in diseases and with aging.
C1 [Sztretye, Monika; Dienes, Beatrix; Gonczi, Monika; Czirjak, Tamas; Csernoch, Laszlo; Szentesi, Peter] Univ Debrecen, Fac Med, Dept Physiol, H-4002 Debrecen, Hungary.
   [Dux, Laszlo; Keller-Pinter, Aniko] Univ Szeged, Fac Med, Dept Biochem, H-6720 Szeged, Hungary.
C3 University of Debrecen; Szeged University
RP Szentesi, P (corresponding author), Univ Debrecen, Fac Med, Dept Physiol, H-4002 Debrecen, Hungary.; Keller-Pintér, A (corresponding author), Univ Szeged, Fac Med, Dept Biochem, H-6720 Szeged, Hungary.
EM szentesi.peter@med.unideb.hu; keller.aniko@med.u-szeged.hu
RI Gonczi, Monika/ABD-1465-2021; Dux, László/B-6174-2012; Keller-Pinter,
   Aniko/A-9608-2013
OI Laszlo, Dux/0000-0002-1270-1678; Dienes, Beatrix/0000-0002-3110-0296;
   Szentesi, Peter/0000-0003-2621-2282; Csernoch,
   Laszlo/0000-0002-2446-1456; Sztretye, Monika/0000-0002-5946-6986;
   Keller-Pinter, Aniko/0000-0002-4105-8458; Gonczi,
   Monika/0000-0002-8421-4369
FU Hungarian National Research, Development and Innovation Office (Hungary)
   [NKFIH NK-115461, PD-128370, GINOP-2.3.2-15-2016-00040,
   EFOP-3.6.2-16-2017-00006]; Higher Education Institutional Excellence
   Programme of the Ministry of Human Capacities in Hungary of the
   University of Debrecen [20428-3/2018/FEKUTSTRAT]; Hungarian Academy of
   Sciences; New National Excellence Program of the Ministry for Innovation
   and Technology Sciences [UNKP-18-4-DE-157, UNKP-19-4-SZTE-23]
FX This work was supported by NKFIH NK-115461, PD-128370,
   GINOP-2.3.2-15-2016-00040, and EFOP-3.6.2-16-2017-00006 grants of the
   Hungarian National Research, Development and Innovation Office (Hungary)
   and was financed by the Higher Education Institutional Excellence
   Programme of the Ministry of Human Capacities in Hungary, within the
   framework of the 20428-3/2018/FEKUTSTRAT thematic programme of the
   University of Debrecen. Additional fundings are Janos Bolyai Research
   Scholarship of the Hungarian Academy of Sciences (to A. K.-P. and M.
   Sz.) and New National Excellence Program of the Ministry for Innovation
   and Technology Sciences (UNKP-18-4-DE-157 to M. Sz. and
   UNKP-19-4-SZTE-23 to A. K.-P.).
CR Aguirre V, 2002, J BIOL CHEM, V277, P1531, DOI 10.1074/jbc.M101521200
   Aguirre V, 2000, J BIOL CHEM, V275, P9047, DOI 10.1074/jbc.275.12.9047
   Ali-Nehari A, 2012, KOREAN J CHEM ENG, V29, P329, DOI 10.1007/s11814-011-0186-2
   Amengual J, 2008, OBESITY, V16, P585, DOI 10.1038/oby.2007.104
   [Anonymous], J PHYSIOL SCI
   [Anonymous], 2013, MEDIAT INFLAMM
   [Anonymous], REDOX REPORT
   [Anonymous], 2011, MARINE BIOACTIVE COM, DOI [10.1007/978-1-4614--1247-2_2, DOI 10.1007/978-1-4614--1247-2_2]
   Aoi W, 2008, BIOCHEM BIOPH RES CO, V366, P892, DOI 10.1016/j.bbrc.2007.12.019
   Aoi W, 2014, SUBCELL BIOCHEM, V77, P175, DOI 10.1007/978-94-007-7920-4_15
   Arunkumar E, 2012, FOOD FUNCT, V3, P120, DOI 10.1039/c1fo10161g
   Bagi Z, 2003, AM J PHYSIOL-HEART C, V285, pH2277, DOI 10.1152/ajpheart.00448.2003
   Barros MP, 2014, NUTRIENTS, V6, P1293, DOI 10.3390/nu6031293
   BENDICH A, 1989, FASEB J, V3, P1927, DOI 10.1096/fasebj.3.8.2656356
   Beppu M, 2001, BIOL PHARM BULL, V24, P575, DOI 10.1248/bpb.24.575
   Berger MM, 2005, CLIN NUTR, V24, P172, DOI 10.1016/j.clnu.2004.10.003
   Bloomer RJ, 2007, SPORTS MED, V37, P519, DOI 10.2165/00007256-200737060-00005
   Bloomer RJ, 2005, INT J SPORT NUTR EXE, V15, P401, DOI 10.1123/ijsnem.15.4.401
   Boussiba S, 2000, PHYSIOL PLANTARUM, V108, P111, DOI 10.1034/j.1399-3054.2000.108002111.x
   Brewer GJ, 2010, EXP GERONTOL, V45, P173, DOI 10.1016/j.exger.2009.11.007
   Brown DR, 2018, FRONT NUTR, V4, DOI 10.3389/fnut.2017.00076
   Bullon P, 2014, PERIODONTOL 2000, V64, P139, DOI 10.1111/j.1600-0757.2012.00455.x
   Campisi J, 2013, ANNU REV PHYSIOL, V75, P685, DOI 10.1146/annurev-physiol-030212-183653
   Capelli B, 2019, FUNCT FOODS HEALTH D, V9, P430, DOI 10.31989/ffhd.v9i6.584
   Cefalu CA, 2011, CLIN GERIATR MED, V27, P491, DOI 10.1016/j.cger.2011.07.001
   Cesari M, 2004, AM J CLIN NUTR, V79, P289
   Chen Q, 2018, EUR J PHARMACOL, V840, P33, DOI 10.1016/j.ejphar.2018.09.028
   Cherednichenko G, 2004, CIRC RES, V94, P478, DOI 10.1161/01.RES.0000115554.65513.7C
   Chew BP, 1999, ANTICANCER RES, V19, P1849
   Chiu TT, 2010, MOL BIOL CELL, V21, P3529, DOI 10.1091/mbc.E10-04-0316
   Cui Hang, 2012, J Signal Transduct, V2012, P646354, DOI 10.1155/2012/646354
   Davinelli S, 2018, NUTRIENTS, V10, DOI 10.3390/nu10040522
   Di Meo S, 2017, J ENDOCRINOL, V233, pR15, DOI 10.1530/JOE-16-0598
   Dumas JF, 2009, DIABETES METAB, V35, P159, DOI 10.1016/j.diabet.2009.02.002
   Egginton S, 2010, EXP PHYSIOL, V95, P971, DOI 10.1113/expphysiol.2010.053421
   Evans JL, 2005, ANTIOXID REDOX SIGN, V7, P1040, DOI 10.1089/ars.2005.7.1040
   Evans JL, 2005, CURR DIABETES REV, V1, P299, DOI 10.2174/157339905774574365
   Fassett RG, 2011, MAR DRUGS, V9, P447, DOI 10.3390/md9030447
   Fassett RG, 2009, FUTUR CARDIOL, V5, P333, DOI [10.2217/fca.09.19, 10.2217/FCA.09.19]
   Fusco D, 2007, CLIN INTERV AGING, V2, P377
   Galasso C, 2018, MAR DRUGS, V16, DOI 10.3390/md16080247
   Georges J, 2018, J NUTR METAB, V2018, DOI 10.1155/2018/7625981
   Gomez-Cabrera MC, 2008, FREE RADICAL BIO MED, V44, P126, DOI 10.1016/j.freeradbiomed.2007.02.001
   Grimmig Beth, 2018, Oncotarget, V9, P10388, DOI 10.18632/oncotarget.23737
   Guerra BA, 2011, INT IMMUNOPHARMACOL, V11, P2220, DOI 10.1016/j.intimp.2011.10.004
   Hama S, 2012, J PHARM SCI-US, V101, P2909, DOI 10.1002/jps.23216
   HARMAN D, 1972, J AM GERIATR SOC, V20, P145, DOI 10.1111/j.1532-5415.1972.tb00787.x
   HARMAN D, 1956, J GERONTOL, V11, P298, DOI 10.1093/geronj/11.3.298
   He Q, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/654198
   Head E, 2008, VET CLIN N AM-SMALL, V38, P167, DOI 10.1016/j.cvsm.2007.10.002
   Helfrich Yolanda Rosi, 2008, Dermatol Nurs, V20, P177
   Hussein G, 2006, J NAT PROD, V69, P443, DOI 10.1021/np050354+
   Hussein G, 2007, LIFE SCI, V80, P522, DOI 10.1016/j.lfs.2006.09.041
   Hwang E, 2014, J MED FOOD, V17, P985, DOI 10.1089/jmf.2013.2999
   Ikeuchi M, 2006, BIOL PHARM BULL, V29, P2106, DOI 10.1248/bpb.29.2106
   Inoue M, 2012, BIOCHEM PHARMACOL, V84, P692, DOI 10.1016/j.bcp.2012.05.021
   Ishiki M, 2013, ENDOCRINOLOGY, V154, P2600, DOI 10.1210/en.2012-2198
   Ishikura S, 2007, BIOCHEM BIOPH RES CO, V353, P1074, DOI 10.1016/j.bbrc.2006.12.140
   Jaldin-Fincati JR, 2017, TRENDS ENDOCRIN MET, V28, P597, DOI 10.1016/j.tem.2017.05.002
   Johnson JM, 2018, J MOL CELL CARDIOL, V121, P94, DOI 10.1016/j.yjmcc.2018.07.001
   Kamath BS, 2008, EUR J PHARMACOL, V590, P387, DOI 10.1016/j.ejphar.2008.06.042
   Kanazashi M, 2013, ACTA PHYSIOL, V207, P405, DOI 10.1111/apha.12018
   Kanazashi M, 2014, EXP PHYSIOL, V99, P1065, DOI 10.1113/expphysiol.2014.079988
   Kim SH, 2018, NUTRIENTS, V10, DOI 10.3390/nu10091137
   Kim YJ, 2009, J AGR FOOD CHEM, V57, P8793, DOI 10.1021/jf9019745
   Klinkenberg LJJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0079280
   Kuhn R, 1938, ANGEW CHEM-GER EDIT, V51, P0465, DOI 10.1002/ange.19380512703
   Lee DH, 2011, FOOD CHEM TOXICOL, V49, P271, DOI 10.1016/j.fct.2010.10.029
   Lee YM, 2008, J BIOL CHEM, V283, P33969, DOI 10.1074/jbc.M804469200
   LEID M, 1992, CELL, V68, P377, DOI 10.1016/0092-8674(92)90478-U
   Lin MT, 2006, NATURE, V443, P787, DOI 10.1038/nature05292
   Liu PH, 2014, J CLIN BIOCHEM NUTR, V54, P86, DOI 10.3164/jcbn.13-110
   LIU Q, 1993, MOL ENDOCRINOL, V7, P651, DOI 10.1210/me.7.5.651
   Liu SZ, 2018, J CACHEXIA SARCOPENI, V9, P826, DOI 10.1002/jcsm.12318
   Liu XB, 2009, FORUM NUTR, V61, P129, DOI 10.1159/000212745
   Lu YP, 2010, BRAIN RES, V1360, P40, DOI 10.1016/j.brainres.2010.09.016
   Bonet ML, 2012, BBA-MOL CELL BIOL L, V1821, P177, DOI 10.1016/j.bbalip.2011.06.001
   Ma JH, 2014, J BIOL CHEM, V289, P133, DOI 10.1074/jbc.M113.533240
   Maezawa T, 2017, J PHYSIOL SCI, V67, P603, DOI 10.1007/s12576-016-0492-x
   Manabe E, 2008, J CELL BIOCHEM, V103, P1925, DOI 10.1002/jcb.21583
   MANGELSDORF DJ, 1992, GENE DEV, V6, P329, DOI 10.1101/gad.6.3.329
   Manolescu DC, 2010, J NUTR, V140, P311, DOI 10.3945/jn.109.115147
   Maoka T, 2011, MAR DRUGS, V9, P278, DOI 10.3390/md9020278
   Mashhadi NS, 2018, ASIA PAC J CLIN NUTR, V27, P341, DOI 10.6133/apjcn.052017.11
   McNulty HP, 2007, BBA-BIOMEMBRANES, V1768, P167, DOI 10.1016/j.bbamem.2006.09.010
   Meissner G, 2004, CIRC RES, V94, P418, DOI 10.1161/01.RES.0000122072.43826.98
   Miyawaki H, 2008, J CLIN BIOCHEM NUTR, V43, P69, DOI 10.3164/jcbn.2008048
   Muller FL, 2007, FREE RADICAL BIO MED, V43, P477, DOI 10.1016/j.freeradbiomed.2007.03.034
   Naguib YMA, 2000, J AGR FOOD CHEM, V48, P1150, DOI 10.1021/jf991106k
   Naito Y, 2004, BIOFACTORS, V20, P49, DOI 10.1002/biof.5520200105
   Ni YH, 2015, SCI REP-UK, V5, DOI 10.1038/srep17192
   O'Donnell E, 1998, NEUROBIOL AGING, V19, P461, DOI 10.1016/S0197-4580(98)00082-7
   Otton R, 2010, CHEM-BIOL INTERACT, V186, P306, DOI 10.1016/j.cbi.2010.05.011
   Park CH, 2015, J MED FOOD, V18, P337, DOI 10.1089/jmf.2014.3174
   Park JS, 2010, NUTR METAB, V7, DOI 10.1186/1743-7075-7-18
   Paz K, 1997, J BIOL CHEM, V272, P29911, DOI 10.1074/jbc.272.47.29911
   Persson B, 2009, CHEM-BIOL INTERACT, V178, P94, DOI 10.1016/j.cbi.2008.10.040
   Phetcharat L, 2015, CLIN INTERV AGING, V10, P1849, DOI 10.2147/CIA.S90092
   Polotow TG, 2014, NUTRIENTS, V6, P5819, DOI 10.3390/nu6125819
   Powers SK, 2008, PHYSIOL REV, V88, P1243, DOI 10.1152/physrev.00031.2007
   Powers SK, 2007, J APPL PHYSIOL, V102, P2389, DOI 10.1152/japplphysiol.01202.2006
   Powers SK, 2014, SPORTS MED, V44, pS155, DOI 10.1007/s40279-014-0255-x
   Powers SK, 2012, CURR OPIN CLIN NUTR, V15, P240, DOI 10.1097/MCO.0b013e328352b4c2
   Powers SK, 2005, AM J PHYSIOL-REG I, V288, pR337, DOI 10.1152/ajpregu.00469.2004
   Rao AR, 2013, J AGR FOOD CHEM, V61, P3842, DOI 10.1021/jf304609j
   Rattan SIS, 2006, FREE RADICAL RES, V40, P1230, DOI 10.1080/10715760600911303
   Res PT, 2013, MED SCI SPORT EXER, V45, P1158, DOI 10.1249/MSS.0b013e31827fddc4
   Rhee EJ, 2012, DIABETES METAB J, V36, P167
   Ristow M, 2014, NAT MED, V20, P709, DOI 10.1038/nm.3624
   Rivera S, 2012, MOLECULES, V17, P11255, DOI 10.3390/molecules170911255
   Rodriguez-Amaya DB, 2010, J FOOD COMPOS ANAL, V23, P726, DOI 10.1016/j.jfca.2010.03.008
   Romano Antonino D, 2010, J Nephrol, V23 Suppl 15, pS29
   Roohbakhsh A, 2017, BIOMED PHARMACOTHER, V91, P31, DOI 10.1016/j.biopha.2017.04.057
   Rovira-Llopis S, 2017, REDOX BIOL, V11, P637, DOI 10.1016/j.redox.2017.01.013
   Ruegsegger GN, 2018, J CLIN INVEST, V128, P3671, DOI 10.1172/JCI120843
   Ruiz A, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-017-18844-3
   Saito M, 2012, GRAEF ARCH CLIN EXP, V250, P239, DOI 10.1007/s00417-011-1843-1
   Salmon AB, 2010, FREE RADICAL BIO MED, V48, P642, DOI 10.1016/j.freeradbiomed.2009.12.015
   Santos SD, 2012, J FOOD SCI, V77, pH141, DOI 10.1111/j.1750-3841.2012.02762.x
   Schreiber I, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-17595-5
   Shabalina IG, 2017, AGING-US, V9, P315, DOI 10.18632/aging.101174
   Shibaguchi T, 2016, PHYSIOL REP, V4, DOI 10.14814/phy2.12885
   Sies H, 2004, PHOTOCH PHOTOBIO SCI, V3, P749, DOI 10.1039/b316082c
   Sies H, 2017, ANNU REV BIOCHEM, V86, P715, DOI 10.1146/annurev-biochem-061516-045037
   SLEEMAN MW, 1995, MOL CELL ENDOCRINOL, V108, P161, DOI 10.1016/0303-7207(95)03473-K
   Soyal S, 2006, DIABETOLOGIA, V49, P1477, DOI 10.1007/s00125-006-0268-6
   Suganuma K, 2010, J DERMATOL SCI, V58, P136, DOI 10.1016/j.jdermsci.2010.02.009
   Swomley AM, 2015, ARCH TOXICOL, V89, P1669, DOI 10.1007/s00204-015-1556-z
   Szentesi P, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/4617801
   Takami M, 2019, J CLIN BIOCHEM NUTR, V64, P79, DOI 10.3164/jcbn.18-40
   Toledo FGS, 2007, DIABETES, V56, P2142, DOI 10.2337/db07-0141
   Tominaga K, 2012, ACTA BIOCHIM POL, V59, P43
   Treves S, 2012, BIOCHEM J, V441, P731, DOI 10.1042/BJ20111457
   Uysal KT, 1997, NATURE, V389, P610, DOI 10.1038/39335
   Valavanidis A, 2009, J ENVIRON SCI HEAL C, V27, P120, DOI 10.1080/10590500902885684
   Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
   Vina Jose, 2004, Molecular Aspects of Medicine, V25, P117, DOI 10.1016/j.mam.2004.02.013
   Viña J, 2013, ANTIOXID REDOX SIGN, V19, P779, DOI 10.1089/ars.2012.5111
   Visioli F, 2017, FOOD FUNCT, V8, P39, DOI [10.1039/C6FO01721E, 10.1039/c6fo01721e]
   Wolf AM, 2010, J NUTR BIOCHEM, V21, P381, DOI 10.1016/j.jnutbio.2009.01.011
   WOLF G, 1992, NUTR REV, V50, P270, DOI 10.1111/j.1753-4887.1992.tb01345.x
   Wu DF, 2003, ALCOHOL RES HEALTH, V27, P277
   Wu WQ, 2014, FOOD FUNCT, V5, P158, DOI 10.1039/c3fo60400d
   Xu LB, 2015, INT J CLIN EXP PATHO, V8, P6083
   YAMADA T, 1975, J LAB CLIN MED, V86, P38
   Yang JL, 2011, AM J PHYSIOL-ENDOC M, V301, pE132, DOI 10.1152/ajpendo.00629.2010
   Yaribeygi H, 2020, DIABETIC MED, V37, P11, DOI 10.1111/dme.13943
   Yoon HS, 2014, J MED FOOD, V17, P810, DOI 10.1089/jmf.2013.3060
   Yoshihara T, 2018, J ZHEJIANG UNIV-SC B, V19, P844, DOI [10.1631/jzus.B1800076, 10.1631/jzus.b1800076]
   Yu TZ, 2019, J CELL PHYSIOL, V234, P13292, DOI 10.1002/jcp.28006
   Yuan JP, 2011, MOL NUTR FOOD RES, V55, P150, DOI 10.1002/mnfr.201000414
   Zhande R, 2002, MOL CELL BIOL, V22, P1016, DOI 10.1128/MCB.22.4.1016-1026.2002
   Zhu XY, 2018, J DIABETES RES, V2018, DOI 10.1155/2018/6730315
   Zirnniak P, 2011, FREE RADICAL BIO MED, V51, P1087, DOI 10.1016/j.freeradbiomed.2011.05.039
NR 154
TC 142
Z9 149
U1 8
U2 51
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD NOV 11
PY 2019
VL 2019
AR 3849692
DI 10.1155/2019/3849692
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA JQ8AO
UT WOS:000499161600008
PM 31814873
OA Green Published, Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU O'Brien, PD
   Hinder, LM
   Sakowski, SA
   Feldman, EL
AF O'Brien, Phillipe D.
   Hinder, Lucy M.
   Sakowski, Stacey A.
   Feldman, Eva L.
TI ER Stress in Diabetic Peripheral Neuropathy: A New Therapeutic Target
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE;
   GLUCOSE-REGULATED PROTEINS; DORSAL-ROOT GANGLION; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; CALCIUM HOMEOSTASIS; CELL-SURVIVAL; CHEMICAL
   CHAPERONES; SENSORY NEURONS
AB Significance: Diabetes and other diseases that comprise the metabolic syndrome have reached epidemic proportions. Diabetic peripheral neuropathy (DPN) is the most prevalent complication of diabetes, affecting similar to 50% of diabetic patients. Characterized by chronic pain or loss of sensation, recurrent foot ulcerations, and risk for amputation, DPN is associated with significant morbidity and mortality. Mechanisms underlying DPN pathogenesis are complex and not well understood, and no effective treatments are available. Thus, an improved understanding of DPN pathogenesis is critical for the development of successful therapeutic options. Recent Advances: Recent research implicates endoplasmic reticulum (ER) stress as a novel mechanism in the onset and progression of DPN. ER stress activates the unfolded protein response (UPR), a well-orchestrated signaling cascade responsible for relieving stress and restoring normal ER function. Critical Issues: During times of extreme or chronic stress, such as that associated with diabetes, the UPR may be insufficient to alleviate ER stress, resulting in apoptosis. Here, we discuss the potential role of ER stress in DPN, as well as evidence demonstrating how ER stress intersects with pathways involved in DPN development and progression. An improved understanding of how ER stress contributes to peripheral nerve dysfunction in diabetes will provide important insight into DPN pathogenesis. Future Directions: Future studies aimed at gaining the necessary insight into ER stress in DPN pathogenesis will ultimately facilitate the development of novel therapies.
C1 [O'Brien, Phillipe D.; Hinder, Lucy M.; Feldman, Eva L.] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA.
   [Sakowski, Stacey A.] Univ Michigan, A Alfred Taubman Med Res Inst, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan
RP Feldman, EL (corresponding author), Univ Michigan, Dept Neurol, 109 Zina Pitcher Pl 5017 AAT BSRB, Ann Arbor, MI 48109 USA.
EM efeldman@umich.edu
RI O'Brien, Phillipe/W-4268-2019
OI O'Brien, Phillipe/0000-0002-6365-3477; Hinder, Lucy/0000-0002-5206-8010;
   Feldman, Eva/0000-0002-9162-2694
FU Program for Neurology Research Discovery; A. Alfred Taubman Medical
   Research Institute; Juvenile Diabetes Research Foundation
FX The authors would like to thank Mrs. Judith Bentley for excellent
   administrative support during the preparation of this article. Funding
   support is provided by the Program for Neurology Research & Discovery
   and the A. Alfred Taubman Medical Research Institute. L.M.H. is funded
   by a fellowship from the Juvenile Diabetes Research Foundation.
CR Anitei M, 2006, CURR BIOL, V16, pR418, DOI 10.1016/j.cub.2006.05.010
   [Anonymous], 2011, National Diabetes Fact Sheet: National Estimates and General Information on Diabetes and Prediabetes in the United States, 2011
   Ansquer JC, 2009, CURR PHARM DESIGN, V15, P537, DOI 10.2174/138161209787315701
   Back SH, 2012, ANNU REV BIOCHEM, V81, P767, DOI 10.1146/annurev-biochem-072909-095555
   Bashan N, 2009, PHYSIOL REV, V89, P27, DOI 10.1152/physrev.00014.2008
   Bek MF, 2006, AM J PATHOL, V168, P20, DOI 10.2353/ajpath.2006.040774
   Bertolotti A, 2000, NAT CELL BIOL, V2, P326, DOI 10.1038/35014014
   BOOTH C, 1989, CELL, V59, P729, DOI 10.1016/0092-8674(89)90019-6
   BRETSCHER MS, 1993, SCIENCE, V261, P1280, DOI 10.1126/science.8362242
   Brussee V, 2004, DIABETES, V53, P1824, DOI 10.2337/diabetes.53.7.1824
   Callaghan BC, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007543.pub2
   Cao SS, 2013, EXPERT OPIN THER TAR, V17, P437, DOI 10.1517/14728222.2013.756471
   Cermenati G, 2012, J LIPID RES, V53, P300, DOI 10.1194/jlr.M021188
   Chen Y, 2012, DIABETOLOGIA, V55, P2533, DOI 10.1007/s00125-012-2594-1
   Cowie CC, 2009, DIABETES CARE, V32, P287, DOI 10.2337/dc08-1296
   D'Antonio M, 2013, J EXP MED, V210, P821, DOI 10.1084/jem.20122005
   DORNER AJ, 1989, J BIOL CHEM, V264, P20602
   DRUMMOND IAS, 1987, J BIOL CHEM, V262, P12801
   DYCK PJ, 1993, NEUROLOGY, V43, P817, DOI 10.1212/WNL.43.4.817
   Edwards JL, 2008, PHARMACOL THERAPEUT, V120, P1, DOI 10.1016/j.pharmthera.2008.05.005
   Eizirik DL, 2013, DIABETOLOGIA, V56, P234, DOI 10.1007/s00125-012-2762-3
   Engin F, 2010, DIABETES OBES METAB, V12, P108, DOI 10.1111/j.1463-1326.2010.01282.x
   Feng B, 2003, NAT CELL BIOL, V5, P781, DOI 10.1038/ncb1035
   Flamment M, 2012, TRENDS ENDOCRIN MET, V23, P381, DOI 10.1016/j.tem.2012.06.003
   Geiss LS, 2010, AM J PREV MED, V38, P403, DOI 10.1016/j.amepre.2009.12.029
   Görlach A, 2006, ANTIOXID REDOX SIGN, V8, P1391, DOI 10.1089/ars.2006.8.1391
   González-Clemente JM, 2005, CLIN ENDOCRINOL, V63, P525, DOI 10.1111/j.1365-2265.2005.02376.x
   Gorman AM, 2012, PHARMACOL THERAPEUT, V134, P306, DOI 10.1016/j.pharmthera.2012.02.003
   Gregor MF, 2009, DIABETES, V58, P693, DOI 10.2337/db08-1220
   Grote CW, 2011, EXP DIABETES RES, DOI 10.1155/2011/212571
   Hager L, 2012, J BIOL CHEM, V287, P20755, DOI 10.1074/jbc.M112.340919
   Harding HP, 2000, MOL CELL, V5, P897, DOI 10.1016/S1097-2765(00)80330-5
   Harding HP, 2003, MOL CELL, V11, P619, DOI 10.1016/S1097-2765(03)00105-9
   Harding HP, 2002, DIABETES, V51, pS455, DOI 10.2337/diabetes.51.2007.S455
   Hinder LM, 2012, J PERIPHER NERV SYST, V17, P10, DOI 10.1111/j.1529-8027.2012.00389.x
   Hosogai N, 2007, DIABETES, V56, P901, DOI 10.2337/db06-0911
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   Hu P, 2006, MOL CELL BIOL, V26, P3071, DOI 10.1128/MCB.26.8.3071-3084.2006
   Huang TJ, 2002, DIABETOLOGIA, V45, P560, DOI 10.1007/s00125-002-0785-x
   Hur J, 2011, BRAIN, V134, P3222, DOI 10.1093/brain/awr228
   International Diabetes Federation, 2013, IDF DIAB ATL
   Kim B, 2011, ENDOCRINOLOGY, V152, P3638, DOI 10.1210/en.2011-0029
   Kostyuk E, 2001, DIABETOLOGIA, V44, P1302, DOI 10.1007/s001250100642
   Krishnamoorthy T, 2001, MOL CELL BIOL, V21, P5018, DOI 10.1128/MCB.21.15.5018-5030.2001
   Lakshmanan AP, 2013, INT J BIOCHEM CELL B, V45, P438, DOI 10.1016/j.biocel.2012.09.017
   Laybutt DR, 2007, DIABETOLOGIA, V50, P752, DOI 10.1007/s00125-006-0590-z
   Li G, 2009, J CELL BIOL, V186, P783, DOI 10.1083/jcb.200904060
   Li JM, 2009, FEBS LETT, V583, P1521, DOI 10.1016/j.febslet.2009.04.007
   Li LX, 2011, J BIOL CHEM, V286, P17809, DOI 10.1074/jbc.M110.180893
   Li YK, 2005, J BIOL CHEM, V280, P21763, DOI 10.1074/jbc.M501759200
   Lin WS, 2009, NAT NEUROSCI, V12, P379, DOI 10.1038/nn.2273
   Lindenmeyer MT, 2008, J AM SOC NEPHROL, V19, P2225, DOI 10.1681/ASN.2007121313
   Lindholm D, 2006, CELL DEATH DIFFER, V13, P385, DOI 10.1038/sj.cdd.4401778
   Lipson KL, 2006, CELL METAB, V4, P245, DOI 10.1016/j.cmet.2006.07.007
   Liu GG, 2008, BIOCHEM BIOPH RES CO, V370, P651, DOI 10.1016/j.bbrc.2008.04.031
   Lupachyk S, 2013, EXP NEUROL, V247, P342, DOI 10.1016/j.expneurol.2012.11.001
   Lupachyk S, 2013, DIABETES, V62, P944, DOI 10.2337/db12-0716
   Ma K, 2002, J BIOL CHEM, V277, P18728, DOI 10.1074/jbc.M200903200
   Ma YJ, 2003, J BIOL CHEM, V278, P34864, DOI 10.1074/jbc.M301107200
   Malhotra JD, 2007, ANTIOXID REDOX SIGN, V9, P2277, DOI 10.1089/ars.2007.1782
   Mantuano E, 2011, J NEUROSCI, V31, P13376, DOI 10.1523/JNEUROSCI.2850-11.2011
   Mayer CM, 2010, ENDOCRINOLOGY, V151, P576, DOI 10.1210/en.2009-1122
   McCullough KD, 2001, MOL CELL BIOL, V21, P1249, DOI 10.1128/MCB.21.4.1249-1259.2001
   Menu P, 2012, CELL DEATH DIS, V3, DOI 10.1038/cddis.2011.132
   Musso G, 2013, PROG LIPID RES, V52, P175, DOI 10.1016/j.plipres.2012.11.002
   Nakagawa T, 2000, NATURE, V403, P98, DOI 10.1038/47513
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Ozawa K, 2005, DIABETES, V54, P657, DOI 10.2337/diabetes.54.3.657
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Padilla A, 2011, BRAIN RES, V1370, P64, DOI 10.1016/j.brainres.2010.11.013
   Pande M, 2011, DIABETES, V60, P1981, DOI 10.2337/db10-1541
   Peng G, 2011, ENDOCRINOLOGY, V152, P2206, DOI 10.1210/en.2010-1369
   Pennuto M, 2008, NEURON, V57, P393, DOI 10.1016/j.neuron.2007.12.021
   Puri P, 2008, GASTROENTEROLOGY, V134, P568, DOI 10.1053/j.gastro.2007.10.039
   SAMBROOK JF, 1990, CELL, V61, P197, DOI 10.1016/0092-8674(90)90798-J
   Scheuner D, 2008, ENDOCR REV, V29, P317, DOI 10.1210/er.2007-0039
   Schindler AJ, 2009, P NATL ACAD SCI USA, V106, P17775, DOI 10.1073/pnas.0910342106
   Schröder M, 2005, MUTAT RES-FUND MOL M, V569, P29, DOI 10.1016/j.mrfmmm.2004.06.056
   Shen JS, 2002, DEV CELL, V3, P99, DOI 10.1016/S1534-5807(02)00203-4
   Sims-Robinson C, 2012, DIABETOLOGIA, V55, P2276, DOI 10.1007/s00125-012-2573-6
   Sjöholm Å, 2006, DIABETES-METAB RES, V22, P4, DOI 10.1002/dmrr.568
   Song BB, 2008, J CLIN INVEST, V118, P3378, DOI 10.1172/JCI34587
   Southwood CM, 2002, NEURON, V36, P585, DOI 10.1016/S0896-6273(02)01045-0
   Stevens FJ, 1999, SEMIN CELL DEV BIOL, V10, P443, DOI 10.1006/scdb.1999.0315
   Stutzmann GE, 2011, PHARMACOL REV, V63, P700, DOI 10.1124/pr.110.003814
   Sugimoto K, 2000, DIABETES-METAB RES, V16, P354, DOI 10.1002/1520-7560(200009/10)16:5<354::AID-DMRR149>3.0.CO;2-H
   Sugimoto K, 2002, J PERIPHER NERV SYST, V7, P44, DOI 10.1046/j.1529-8027.2002.02005.x
   Szegezdi E, 2003, ANN NY ACAD SCI, V1010, P186, DOI 10.1196/annals.1299.032
   Tao JL, 2012, CHINESE MED J-PEKING, V125, P3137, DOI 10.3760/cma.j.issn.0366-6999.2012.17.031
   Timmins JM, 2009, J CLIN INVEST, V119, P2925, DOI 10.1172/JCI38857
   Toth C, 2006, NEUROSCIENCE, V139, P429, DOI 10.1016/j.neuroscience.2005.11.065
   Tu BP, 2004, J CELL BIOL, V164, P341, DOI 10.1083/jcb.200311055
   Urano F, 2000, SCIENCE, V287, P664, DOI 10.1126/science.287.5453.664
   Verkhratsky A, 2005, PHYSIOL REV, V85, P201, DOI 10.1152/physrev.00004.2004
   Vernon PJ, 2013, ANTIOXID REDOX SIGN, V18, P677, DOI 10.1089/ars.2012.4810
   Vincent AM, 2005, FASEB J, V19, P638, DOI 10.1096/fj.04-2513fje
   Vincent AM, 2004, ENDOCR REV, V25, P612, DOI 10.1210/er.2003-0019
   Vincent AM, 2004, REV ENDOCR METAB DIS, V5, P227, DOI 10.1023/B:REMD.0000032411.11422.e0
   Vincent AM, 2011, NAT REV NEUROL, V7, P573, DOI 10.1038/nrneurol.2011.137
   Vincent AM, 2009, J PERIPHER NERV SYST, V14, P257, DOI 10.1111/j.1529-8027.2009.00237.x
   Vincent AM, 2009, DIABETES, V58, P2376, DOI 10.2337/db09-0047
   Vincent AM, 2009, ANTIOXID REDOX SIGN, V11, P425, DOI 10.1089/ars.2008.2235
   Wang HY, 2005, J CELL SCI, V118, P3905, DOI 10.1242/jcs.02513
   Wek RC, 2007, ANTIOXID REDOX SIGN, V9, P2357, DOI 10.1089/ars.2007.1764
   Wiggin TD, 2009, DIABETES, V58, P1634, DOI 10.2337/db08-1771
   Wilson NM, 2012, J DIABETES METAB, V3, DOI 10.4172/2155-6156.S5-004
   Xu QG, 2004, EXP NEUROL, V188, P43, DOI 10.1016/j.expneurol.2004.03.008
   Ylitalo KR, 2011, DIABETES CARE, V34, P1642, DOI 10.2337/dc10-2150
   Yoshida H, 2001, CELL, V107, P881, DOI 10.1016/S0092-8674(01)00611-0
   Zhang KZ, 2008, NATURE, V454, P455, DOI 10.1038/nature07203
   Zherebitskaya E, 2012, ASN NEURO, V4, P1, DOI 10.1042/AN20110038
   Zhong YM, 2012, DIABETES, V61, P492, DOI 10.2337/db11-0315
   Zinszner H, 1998, GENE DEV, V12, P982, DOI 10.1101/gad.12.7.982
NR 113
TC 68
Z9 79
U1 3
U2 41
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD AUG 1
PY 2014
VL 21
IS 4
BP 621
EP 633
DI 10.1089/ars.2013.5807
PG 13
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA AM2DP
UT WOS:000339659600007
PM 24382087
OA Green Published
DA 2025-06-11
ER

PT J
AU Yao, ST
   Tian, H
   Zhao, L
   Li, JG
   Yang, LB
   Yue, F
   Li, YY
   Jiao, P
   Yang, NN
   Wang, YW
   Zhang, XJ
   Qin, SC
AF Yao, Shutong
   Tian, Hua
   Zhao, Li
   Li, Jinguo
   Yang, Libo
   Yue, Feng
   Li, Yanyan
   Jiao, Peng
   Yang, Nana
   Wang, Yiwei
   Zhang, Xiangjian
   Qin, Shucun
TI Oxidized high density lipoprotein induces macrophage apoptosis via
   toll-like receptor 4-dependent CHOP pathway
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE endoplasmic reticulum stress; CCAAT-enhancer-binding protein homologous
   protein; atherosclerosis; oxidative stress
ID ENDOPLASMIC-RETICULUM STRESS; THERAPEUTIC TARGET; CHOLESTEROL EFFLUX;
   ENDOTHELIAL-CELLS; HDL-C; LDL; ATHEROSCLEROSIS; ACCUMULATION; PROMOTES;
   CONTRIBUTES
AB Oxidized HDL (ox-HDL), unlike native HDL that exerts antiatherogenic effects, plays a proatherogenic role. However, the underlying mechanisms are not completely understood. This study was designed to explore the inductive effect of ox-HDL on endoplasmic reticulum (ER) stress-CCAAT-enhancer-binding protein homologous protein (CHOP)-mediated macrophage apoptosis and its upstream mechanisms. Our results showed that ox-HDL could be ingested by macrophages, causing intracellular lipid accumulation. As with tunicamycin (an ER stress inducer), ox-HDL induced macrophage apoptosis with concomitant activation of ER stress pathway, including nuclear translocation of activating transcription factor 6, phosphorylation of protein kinase-like ER kinase and eukaryotic translation initiation factor 2 alpha, and upregulation of glucose-regulated protein 78 and CHOP, which were inhibited by 4-phenylbutyric acid (PBA, an ER stress inhibitor) and CHOP gene silencing. Additionally, diphenyleneiodonium (DPI, an oxidative stress inhibitor), probucol (a reactive oxygen species scavenger), and toll-like receptor 4 (TLR4) silencing reduced ox-HDL-induced macrophage apoptosis, oxidative stress, and CHOP upregulation. Moreover, HDL isolated from patients with metabolic syndrome induced macrophage apoptosis, oxidative stress, and CHOP upregulation, which were blocked by PBA and DPI.(Jlr) These data indicate that ox-HDL may activate ER stress-CHOP-induced apoptotic pathway in macrophages via enhanced oxidative stress and that this pathway may be mediated by TLR4.
C1 [Yao, Shutong; Tian, Hua; Li, Yanyan; Jiao, Peng; Yang, Nana; Qin, Shucun] Taishan Med Univ, Key Lab Atherosclerosis Univ Shandong, Tai An, Shandong, Peoples R China.
   [Yao, Shutong; Tian, Hua; Li, Yanyan; Jiao, Peng; Yang, Nana; Qin, Shucun] Taishan Med Univ, Inst Atherosclerosis, Tai An, Shandong, Peoples R China.
   [Yao, Shutong; Li, Jinguo] Taishan Med Univ, Coll Basic Med Sci, Tai An, Shandong, Peoples R China.
   [Zhao, Li; Wang, Yiwei] Chengde Med Univ, Affiliated Hosp, Chengde, Peoples R China.
   [Yang, Libo; Yue, Feng] Cent Hosp Taian, Dept Endocrinol, Tai An, Shandong, Peoples R China.
   [Zhang, Xiangjian] Hebei Collaborat Innovat Ctr Cardiocerebrovasc Di, Hebei Key Lab Vasc Homeostasis, Shijiazhuang, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical
   Sciences; Taishan University; Shandong First Medical University &
   Shandong Academy of Medical Sciences; Taishan University; Taishan
   University; Shandong First Medical University & Shandong Academy of
   Medical Sciences; Chengde Medical University
RP Qin, SC (corresponding author), Taishan Med Univ, Key Lab Atherosclerosis Univ Shandong, Tai An, Shandong, Peoples R China.; Qin, SC (corresponding author), Taishan Med Univ, Inst Atherosclerosis, Tai An, Shandong, Peoples R China.
EM shucunqin@hotmail.com
RI Li, YanY/ABC-3649-2020
OI Zhang, Xiangjian/0000-0003-0114-1668
FU Taishan Scholars Foundation of Shandong Province [ts201511057]; National
   Natural Science Foundations of China [81370381, 81570410, 91539114]
FX This research was supported by the Taishan Scholars Foundation of
   Shandong Province (ts201511057) and the National Natural Science
   Foundations of China (81370381, 81570410, 91539114). The authors declare
   no conflicts of interest.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Assinger A, 2010, ATHEROSCLEROSIS, V212, P153, DOI 10.1016/j.atherosclerosis.2010.05.010
   Bots ML, 2007, LANCET, V370, P153, DOI 10.1016/S0140-6736(07)61088-5
   Boullier A, 2006, ARTERIOSCL THROM VAS, V26, P1169, DOI 10.1161/01.ATV.0000210279.97308.9a
   Brown DI, 2015, CIRC RES, V116, P531, DOI 10.1161/CIRCRESAHA.116.303584
   Callegari E, 2006, INT J MOL MED, V18, P209
   Carrillo-Sepulveda MA, 2015, J MOL MED, V93, P1341, DOI 10.1007/s00109-015-1318-7
   Chai Y. L., 2016, GENET MOL RES, V15
   Chen XP, 2007, VASC PHARMACOL, V47, P1, DOI 10.1016/j.vph.2007.01.004
   Choi SH, 2009, CIRC RES, V104, P1355, DOI 10.1161/CIRCRESAHA.108.192880
   den Dekker WK, 2010, ATHEROSCLEROSIS, V209, P314, DOI 10.1016/j.atherosclerosis.2009.09.075
   DeVries-Seimon T, 2005, J CELL BIOL, V171, P61, DOI 10.1083/jcb.200502078
   Ding R, 2015, APMIS, V123, P410, DOI 10.1111/apm.12362
   Erbay E, 2009, NAT MED, V15, P1383, DOI 10.1038/nm.2067
   Feng B, 2003, NAT CELL BIOL, V5, P781, DOI 10.1038/ncb1035
   Ferretti G, 2006, ATHEROSCLEROSIS, V184, P1, DOI 10.1016/j.atherosclerosis.2005.08.008
   Gadi R, 2013, INT J CARDIOL, V167, P646, DOI 10.1016/j.ijcard.2012.05.052
   Girona J, 2003, BBA-MOL CELL BIOL L, V1633, P143, DOI 10.1016/S1388-1981(03)00108-2
   Hansen MK, 2010, J CARDIOVASC PHARM T, V15, P196, DOI 10.1177/1074248410362891
   Hewing B, 2014, ARTERIOSCL THROM VAS, V34, P779, DOI 10.1161/ATVBAHA.113.303044
   Higashimori M, 2011, ARTERIOSCL THROM VAS, V31, P50, DOI 10.1161/ATVBAHA.110.210971
   Hong D, 2014, ATHEROSCLEROSIS, V235, P310, DOI 10.1016/j.atherosclerosis.2014.04.028
   Ishiyama J, 2011, J LIPID RES, V52, P299, DOI [10.1194/jlr.M007104, 10.1194/jlr.m007104]
   Ivanova EA, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17020193
   Kar S, 2013, BBA-MOL CELL BIOL L, V1831, P1714, DOI 10.1016/j.bbalip.2013.08.008
   Kontush A, 2008, CURR DIABETES REP, V8, P51, DOI 10.1007/s11892-008-0010-5
   Kotani K, 2012, CLIN CHIM ACTA, V414, P125, DOI 10.1016/j.cca.2012.08.021
   Maiolino G, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/714653
   Matsunaga T, 2003, BIOCHEM BIOPH RES CO, V303, P313, DOI 10.1016/S0006-291X(03)00308-5
   Moore KJ, 2011, CELL, V145, P341, DOI 10.1016/j.cell.2011.04.005
   Nakajima T, 2000, ANN CLIN BIOCHEM, V37, P179, DOI 10.1258/0004563001899186
   Nissen SE, 2007, NEW ENGL J MED, V356, P1304, DOI 10.1056/NEJMoa070635
   Otocka-Kmiecik A, 2012, PROG LIPID RES, V51, P314, DOI 10.1016/j.plipres.2012.03.003
   Parolini C, 2008, J AM COLL CARDIOL, V51, P1098, DOI 10.1016/j.jacc.2007.12.010
   Pedruzzi E, 2004, MOL CELL BIOL, V24, P10703, DOI 10.1128/MCB.24.24.10703-10717.2004
   Peterson SJ, 2016, PROSTAG OTH LIPID M, V123, P68, DOI 10.1016/j.prostaglandins.2016.04.004
   Pirillo A, 2013, CURR PHARM DESIGN, V19, P3841, DOI 10.2174/13816128113199990298
   Rader DJ, 2014, LANCET, V384, P618, DOI 10.1016/S0140-6736(14)61217-4
   Schwartz GG, 2012, NEW ENGL J MED, V367, P2089, DOI 10.1056/NEJMoa1206797
   Scull CM, 2011, ARTERIOSCL THROM VAS, V31, P2792, DOI 10.1161/ATVBAHA.111.224881
   Shao BH, 2014, CIRC RES, V114, P1733, DOI 10.1161/CIRCRESAHA.114.303454
   Soumyarani VS, 2012, MOL CELL BIOCHEM, V366, P277, DOI 10.1007/s11010-012-1306-y
   Soumyarani VS, 2014, J BIOCHEM MOL TOXIC, V28, P481, DOI 10.1002/jbt.21588
   Taylor AJ, 2008, AM J CARDIOL, V101, p36B, DOI 10.1016/j.amjcard.2008.02.030
   Thorp E, 2009, CELL METAB, V9, P474, DOI 10.1016/j.cmet.2009.03.003
   Tiwari RL, 2008, MED RES REV, V28, P483, DOI 10.1002/med.20118
   Tsukano H, 2010, ARTERIOSCL THROM VAS, V30, P1925, DOI 10.1161/ATVBAHA.110.206094
   Wang Y, 2014, J ATHEROSCLER THROMB, V21, P204, DOI 10.5551/jat.19448
   Yao ST, 2015, J LIPID RES, V56, P836, DOI 10.1194/jlr.M055400
   Yao ST, 2014, J BIOL CHEM, V289, P4032, DOI 10.1074/jbc.M113.524512
   Yao ST, 2013, J ATHEROSCLER THROMB, V20, P94, DOI 10.5551/jat.13425
   Yao ST, 2012, BBA-MOL CELL BIOL L, V1821, P954, DOI 10.1016/j.bbalip.2012.03.003
   Yu XC, 2014, INT J MOL MED, V34, P886, DOI 10.3892/ijmm.2014.1833
NR 53
TC 31
Z9 71
U1 1
U2 14
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD JAN
PY 2017
VL 58
IS 1
BP 164
EP 177
DI 10.1194/jlr.M071142
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA EI3RJ
UT WOS:000392408700013
PM 27895089
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Su, QZ
   Baker, C
   Christian, P
   Naples, M
   Tong, XD
   Zhang, KZ
   Santha, M
   Adeli, K
AF Su, Qiaozhu
   Baker, Chris
   Christian, Patricia
   Naples, Mark
   Tong, Xuedong
   Zhang, Kezhong
   Santha, Miklos
   Adeli, Khosrow
TI Hepatic mitochondrial and ER stress induced by defective PPARα signaling
   in the pathogenesis of hepatic steatosis
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE peroxisome proliferator-activated receptor-alpha; endoplasmic reticulum;
   mitochondrial and endoplasmic reticulum stress; apolipoprotein B;
   very-low density lipoprotein; hepatic steatosis
ID ENDOPLASMIC-RETICULUM STRESS; APOLIPOPROTEIN B100 SECRETION; ACTIVATED
   RECEPTOR-ALPHA; INSULIN-RESISTANCE; LIPID-METABOLISM; MAMMALIAN-CELLS;
   EXPRESSION; OBESITY; REINITIATION; INFLAMMATION
AB Emerging evidence demonstrates a close interplay between disturbances in mitochondrial function and ER homeostasis in the development of the metabolic syndrome. The present investigation sought to advance our understanding of the communication between mitochondrial dysfunction and ER stress in the onset of hepatic steatosis in male rodents with defective peroxisome proliferator-activated receptor-alpha (PPAR alpha) signaling. Genetic depletion of PPAR alpha or perturbation of PPAR alpha signaling by high-fructose diet compromised the functional activity of metabolic enzymes involved in mitochondrial fatty acid alpha-oxidation and induced hepatic mitochondrial stress in rats and mice. Inhibition of PPAR alpha activity further enhanced the expression of apolipoprotein B (apoB) mRNA and protein, which was associated with reduced mRNA expression of the sarco/endoplasmic reticulum calcium ATPase (SERCA), the induction of hepatic ER stress, and hepatic steatosis. Restoration of PPAR alpha activity recovered the metabolic function of the mitochondria and ER, alleviated systemic hypertriglyceridemia, and improved hepatic steatosis. These findings unveil novel roles for PPAR alpha in mediating stress signals between hepatic subcellular stress-responding machinery and in the onset of hepatic steatosis under conditions of metabolic stress.
C1 [Su, Qiaozhu; Baker, Chris; Christian, Patricia; Naples, Mark; Adeli, Khosrow] Univ Toronto, Hosp Sick Children, Program Mol Struct & Funct, Toronto, ON M5G 1X8, Canada.
   [Su, Qiaozhu; Tong, Xuedong] Univ Nebraska, Dept Nutr & Hlth Sci, Lincoln, NE USA.
   [Zhang, Kezhong] Wayne State Univ, Detroit, MI USA.
   [Santha, Miklos] Hungarian Acad Sci, Inst Biochem, Szeged, Hungary.
   [Santha, Miklos] Hungarian Acad Sci, Biol Res Ctr, H-6701 Szeged, Hungary.
C3 University of Toronto; Hospital for Sick Children (SickKids); University
   of Nebraska System; University of Nebraska Lincoln; Wayne State
   University; HUN-REN; HUN-REN Biological Research Center; Institute of
   Biochemistry - HAS; Hungarian Academy of Sciences; HUN-REN; HUN-REN
   Biological Research Center; Hungarian Academy of Sciences
RP Adeli, K (corresponding author), Hosp Sick Children, DPLM, Div Clin Biochem, 555 Univ Ave, Toronto, ON M5G 1X8, Canada.
EM k.adeli@utoronto.ca
RI Zhang, Zhiwu/P-6156-2016; Tong, Xuedong/ABR-9313-2022
OI Adeli, Khosrow/0000-0002-5839-5709; Su, Qiaozhu/0000-0001-8434-1408;
   Zhang, Kezhong/0000-0002-6062-235X; Tong, Xuedong/0000-0002-0450-2564
FU Heart and Stroke Foundation of Ontario; Postdoctoral Research Fellowship
   from the Canadian Institutes of Health Research (CIHR); CIHR Strategic
   Training Program in Protein Folding and Interaction Dynamics Studentship
   from the University of Toronto; National Institute of Diabetes and
   Digestive and Kidney Diseases [P30DK020572] Funding Source: NIH RePORTER
FX This work was supported by an operating grant from the Heart and Stroke
   Foundation of Ontario to K. Adeli. Q. Su was supported by a Postdoctoral
   Research Fellowship from the Canadian Institutes of Health Research
   (CIHR). P. Christian is a recipient of the CIHR Strategic Training
   Program in Protein Folding and Interaction Dynamics Studentship from the
   University of Toronto.
CR Aoyama T, 1998, J BIOL CHEM, V273, P5678, DOI 10.1074/jbc.273.10.5678
   Basciano H, 2009, AM J PHYSIOL-ENDOC M, V297, pE462, DOI 10.1152/ajpendo.90764.2008
   Bensinger SJ, 2008, NATURE, V454, P470, DOI 10.1038/nature07202
   Bernal-Mizrachi C, 2003, NAT MED, V9, P1069, DOI 10.1038/nm898
   Choi SH, 2011, TRENDS ENDOCRIN MET, V22, P353, DOI 10.1016/j.tem.2011.04.007
   Dekker MJ, 2010, AM J PHYSIOL-ENDOC M, V299, pE685, DOI 10.1152/ajpendo.00283.2010
   Forman BM, 1997, P NATL ACAD SCI USA, V94, P4312, DOI 10.1073/pnas.94.9.4312
   Fu SN, 2011, NATURE, V473, P528, DOI 10.1038/nature09968
   Ginsberg HN, 2009, J LIPID RES, V50, pS162, DOI 10.1194/jlr.R800090-JLR200
   Hayashi T, 2009, TRENDS CELL BIOL, V19, P81, DOI 10.1016/j.tcb.2008.12.002
   Haynes CM, 2010, J CELL SCI, V123, P3849, DOI 10.1242/jcs.075119
   Haynes CM, 2010, MOL CELL, V37, P529, DOI 10.1016/j.molcel.2010.01.015
   Jo H, 2013, HEPATOLOGY, V57, P1366, DOI 10.1002/hep.26126
   Koves TR, 2008, CELL METAB, V7, P45, DOI 10.1016/j.cmet.2007.10.013
   Lindén D, 2001, J LIPID RES, V42, P1831
   Lu PD, 2004, J CELL BIOL, V167, P27, DOI 10.1083/jcb.200408003
   Morino K, 2006, DIABETES, V55, pS9, DOI 10.2337/db06-S002
   Muoio DM, 2006, ANNU REV BIOCHEM, V75, P367, DOI 10.1146/annurev.biochem.75.103004.142512
   Neupert W, 2007, ANNU REV BIOCHEM, V76, P723, DOI 10.1146/annurev.biochem.76.052705.163409
   Nury T, 2013, BIOCHIMIE, V95, P518, DOI 10.1016/j.biochi.2012.11.013
   Ota T, 2008, J CLIN INVEST, V118, P316, DOI 10.1172/JCI32752
   Ozawa K, 2005, DIABETES, V54, P657, DOI 10.2337/diabetes.54.3.657
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Qiu W, 2009, J LIPID RES, V50, P1814, DOI 10.1194/jlr.M800343-JLR200
   Qu S, 2007, AM J PHYSIOL-ENDOC M, V292, pE421, DOI 10.1152/ajpendo.00157.2006
   Reddy JK, 2001, ANNU REV NUTR, V21, P193, DOI 10.1146/annurev.nutr.21.1.193
   Roglans N, 2007, HEPATOLOGY, V45, P778, DOI 10.1002/hep.21499
   Schrauwen P, 2004, DIABETES, V53, P1412, DOI 10.2337/diabetes.53.6.1412
   Sparks JD, 2009, CURR OPIN LIPIDOL, V20, P217, DOI 10.1097/MOL.0b013e32832b3f4c
   Su QZ, 2009, HEPATOLOGY, V50, P77, DOI 10.1002/hep.22960
   Su QZ, 2006, P NATL ACAD SCI USA, V103, P63, DOI 10.1073/pnas.0508207103
   Tsai J, 2009, AM J PHYSIOL-GASTR L, V296, pG1287, DOI 10.1152/ajpgi.90540.2008
   Vattem KM, 2004, P NATL ACAD SCI USA, V101, P11269, DOI 10.1073/pnas.0400541101
   Wek RC, 2007, ANTIOXID REDOX SIGN, V9, P2357, DOI 10.1089/ars.2007.1764
   Zhao Q, 2002, EMBO J, V21, P4411, DOI 10.1093/emboj/cdf445
NR 35
TC 64
Z9 67
U1 0
U2 17
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD JUN
PY 2014
VL 306
IS 11
BP E1264
EP E1273
DI 10.1152/ajpendo.00438.2013
PG 10
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA AJ7SI
UT WOS:000337897000005
PM 24735884
OA Green Published
DA 2025-06-11
ER

PT J
AU Speelman, T
   Dale, L
   Louw, A
   Verhoog, NJD
AF Speelman, Tammy
   Dale, Lieke
   Louw, Ann
   Verhoog, Nicolette J. D.
TI The Association of Acute Phase Proteins in Stress and
   Inflammation-Induced T2D
SO CELLS
LA English
DT Review
DE acute phase response; acute phase proteins; insulin resistance; type II
   diabetes; glucocorticoids; pro-inflammatory cytokines
ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; C-REACTIVE PROTEIN;
   NECROSIS-FACTOR-ALPHA; SERUM AMYLOID-A; INSULIN-RECEPTOR SUBSTRATE-1;
   ADIPOSE-TISSUE DEVELOPMENT; PAI-1 GENE-EXPRESSION; NF-KAPPA-B;
   TNF-ALPHA; METABOLIC SYNDROME
AB Acute phase proteins (APPs), such as plasminogen activator inhibitor-1 (PAI-1), serum amyloid A (SAA), and C-reactive protein (CRP), are elevated in type-2 diabetes (T2D) and are routinely used as biomarkers for this disease. These APPs are regulated by the peripheral mediators of stress (i.e., endogenous glucocorticoids (GCs)) and inflammation (i.e., pro-inflammatory cytokines), with both implicated in the development of insulin resistance, the main risk factor for the development of T2D. In this review we propose that APPs, PAI-1, SAA, and CRP, could be the causative rather than only a correlative link between the physiological elements of risk (stress and inflammation) and the development of insulin resistance.
C1 [Speelman, Tammy; Dale, Lieke; Louw, Ann; Verhoog, Nicolette J. D.] Stellenbosch Univ, Biochem Dept, Van Byl St, ZA-7200 Stellenbosch, South Africa.
C3 Stellenbosch University
RP Verhoog, NJD (corresponding author), Stellenbosch Univ, Biochem Dept, Van Byl St, ZA-7200 Stellenbosch, South Africa.
EM tammyspee195@gmail.com; liekedale@gmail.com; al@sun.ac.za;
   nverhoog@sun.ac.za
RI Louw, Ann/A-7620-2012
OI Verhoog, Nicolette/0000-0002-3786-6452
FU Medical Research Council of South Africa
FX This research was funded by the Medical Research Council of South
   Africa.
CR Ahlin S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0072204
   Akbari M, 2018, INFLAMMOPHARMACOLOGY, V26, P685, DOI 10.1007/s10787-018-0458-0
   ALESSI MC, 1988, THROMB HAEMOSTASIS, V60, P491
   Alessi MC, 1997, DIABETES, V46, P860, DOI 10.2337/diabetes.46.5.860
   Alipourfard I, 2019, MEDIAT INFLAMM, V2019, DOI 10.1155/2019/3560819
   Altalhi R, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22063170
   Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
   Andrews RC, 1999, CLIN SCI, V96, P513, DOI 10.1042/cs0960513
   Armandi A, 2021, METABOLITES, V11, DOI 10.3390/metabo11030155
   Balsara RD, 2006, J BIOL CHEM, V281, P22527, DOI 10.1074/jbc.M512819200
   Banfi C, 2001, DIABETES, V50, P1522, DOI 10.2337/diabetes.50.7.1522
   Barnes PJ, 1998, CLIN SCI, V94, P557, DOI 10.1042/cs0940557
   Barzilay JI, 2001, DIABETES, V50, P2384, DOI 10.2337/diabetes.50.10.2384
   Bastard JP, 2000, DIABETES-METAB RES, V16, P192, DOI 10.1002/1520-7560(200005/06)16:3<192::AID-DMRR114>3.0.CO;2-G
   Batista TM, 2021, DIABETOLOGIA, V64, P994, DOI 10.1007/s00125-021-05415-5
   Bazuine M, 2004, MOL ENDOCRINOL, V18, P1697, DOI 10.1210/me.2003-0213
   Beaupere C, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22020623
   Beck-Nielsen Henning, 2002, Curr Diab Rep, V2, P231
   Binder BR, 2002, NEWS PHYSIOL SCI, V17, P56, DOI 10.1152/nips.01369.2001
   Black PH, 2003, BRAIN BEHAV IMMUN, V17, P350, DOI 10.1016/S0889-1591(03)00048-5
   Burén J, 2008, ARCH BIOCHEM BIOPHYS, V474, P91, DOI 10.1016/j.abb.2008.02.034
   Burhans MS, 2019, COMPR PHYSIOL, V9, P1, DOI 10.1002/cphy.c170040
   Calabro P, 2005, J AM COLL CARDIOL, V46, P1112, DOI 10.1016/j.jacc.2005.06.017
   Carmeliet P, 1997, CIRCULATION, V96, P3180, DOI 10.1161/01.CIR.96.9.3180
   CASTELL JV, 1990, HEPATOLOGY, V12, P1179, DOI 10.1002/hep.1840120517
   Cesari M, 2010, CARDIOVASC THER, V28, pe72, DOI 10.1111/j.1755-5922.2010.00171.x
   Crandall DL, 2006, ARTERIOSCL THROM VAS, V26, P2209, DOI 10.1161/01.ATV.0000235605.51400.9d
   Cray C, 2009, COMPARATIVE MED, V59, P517
   D'Alessandris C, 2007, DIABETOLOGIA, V50, P840, DOI 10.1007/s00125-006-0522-y
   De Buck M, 2016, CURR MED CHEM, V23, P1725, DOI 10.2174/0929867323666160418114600
   de Oliveira EM, 2016, DIABETOLOGIA, V59, P1760, DOI 10.1007/s00125-016-3970-z
   De Taeye B, 2005, CURR OPIN PHARMACOL, V5, P149, DOI 10.1016/j.coph.2005.01.007
   DeFronzo RA, 1997, DIABETES REV, V5, P177
   DEPRAETERE S, 1991, AGENTS ACTIONS, V34, P369, DOI 10.1007/BF01988730
   Du Clos TW, 2000, ANN MED, V32, P274, DOI 10.3109/07853890009011772
   Ebeling P, 1999, DIABETOLOGIA, V42, P1433, DOI 10.1007/s001250051315
   Eklund KK, 2012, CRIT REV IMMUNOL, V32, P335
   Fasshauer M, 2004, J ENDOCRINOL, V183, P561, DOI 10.1677/joe.1.05699
   Faty A, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034031
   FEINSTEIN R, 1993, J BIOL CHEM, V268, P26055
   Fernández-Real JM, 2003, ENDOCR REV, V24, P278, DOI 10.1210/er.2002-0010
   Ferris HA, 2012, J CLIN INVEST, V122, P3854, DOI 10.1172/JCI66180
   Festa A, 2002, DIABETES, V51, P1131, DOI 10.2337/diabetes.51.4.1131
   Festa A, 2006, CIRCULATION, V113, P1753, DOI 10.1161/CIRCULATIONAHA.106.616177
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Filippin-Monteiro FB, 2012, INT J OBESITY, V36, P1032, DOI 10.1038/ijo.2011.193
   Gabay C, 1999, NEW ENGL J MED, V340, P448, DOI 10.1056/NEJM199902113400607
   GANAPATHI MK, 1991, J IMMUNOL, V147, P1261
   GANAPATHI MK, 1988, BIOCHEM BIOPH RES CO, V157, P271, DOI 10.1016/S0006-291X(88)80043-3
   Gao D, 2014, AM J PHYSIOL-ENDOC M, V307, pE289, DOI 10.1152/ajpendo.00430.2013
   Gentry P, 2008, CLINICAL BIOCHEMISTRY OF DOMESTIC ANIMALS, 6TH EDITION, P287, DOI 10.1016/B978-0-12-370491-7.00010-6
   Getz GS, 2016, CURR OPIN LIPIDOL, V27, P531, DOI 10.1097/MOL.0000000000000331
   Gonzalez E, 2011, P NATL ACAD SCI USA, V108, P10162, DOI 10.1073/pnas.1019268108
   Gruys E, 2005, J Zhejiang Univ Sci B, V6, P1045, DOI 10.1631/jzus.2005.B1045
   Guo SD, 2014, J ENDOCRINOL, V220, pT1, DOI 10.1530/JOE-13-0327
   Guo S, 2009, MOL CELL BIOL, V29, P5070, DOI 10.1128/MCB.00138-09
   Hagiwara A, 2012, CELL METAB, V15, P725, DOI 10.1016/j.cmet.2012.03.015
   Hak AE, 1999, ARTERIOSCL THROM VAS, V19, P1986, DOI 10.1161/01.ATV.19.8.1986
   Halleux CM, 1999, J CLIN ENDOCR METAB, V84, P4097, DOI 10.1210/jc.84.11.4097
   Hamar P, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23062972
   He JY, 2006, MOL ENDOCRINOL, V20, P114, DOI 10.1210/me.2005-0107
   HEALY AM, 1994, J BIOL CHEM, V269, P19095
   HEINRICH PC, 1990, BIOCHEM J, V265, P621, DOI 10.1042/bj2650621
   Hotamisligil GS, 1996, SCIENCE, V271, P665, DOI 10.1126/science.271.5249.665
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Hozumi A, 2010, BIOMED RES-TOKYO, V31, P281, DOI 10.2220/biomedres.31.281
   Hua S, 2009, REDOX REP, V14, P187, DOI 10.1179/135100009X12525712409490
   Hunter SJ, 1998, AM J MED, V105, P331, DOI 10.1016/S0002-9343(98)00300-3
   Ito A, 1999, J IMMUNOL, V162, P4260
   James DE, 2021, NAT REV MOL CELL BIO, V22, P751, DOI 10.1038/s41580-021-00390-6
   Janciauskiene S, 2011, ACUTE PHASE PROTEINS - REGULATION AND FUNCTIONS OF ACUTE PHASE PROTEINS, P25
   Ji AL, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0266688
   Jijon HB, 2005, EUR J IMMUNOL, V35, P718, DOI 10.1002/eji.200425688
   JONSSON A, 1976, DIABETOLOGIA, V12, P245, DOI 10.1007/BF00422091
   Juhan-Vague I, 2002, PATHOPHYSIOL HAEMO T, V32, P269, DOI 10.1159/000073579
   Juhan-Vague I, 2000, ANN MED, V32, P78
   JUHANVAGUE I, 1991, DIABETOLOGIA, V34, P457, DOI 10.1007/BF00403280
   KANETY H, 1995, J BIOL CHEM, V270, P23780, DOI 10.1074/jbc.270.40.23780
   Khalid M, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22168590
   Kido Y, 2000, J CLIN INVEST, V105, P199, DOI 10.1172/JCI7917
   Kimura H, 2009, NEPHROL DIAL TRANSPL, V24, P1759, DOI 10.1093/ndt/gfn756
   Kisilevsky R, 2012, AMYLOID, V19, P5, DOI 10.3109/13506129.2011.654294
   Kohler HP, 2002, SWISS MED WKLY, V132, P241
   KONKLE BA, 1992, BLOOD, V79, P2636
   Kramer F, 2008, MOL IMMUNOL, V45, P2678, DOI 10.1016/j.molimm.2007.12.017
   Kroder G, 1996, J CLIN INVEST, V97, P1471, DOI 10.1172/JCI118569
   Kruszynska YT, 2000, DIABETES, V49, P633, DOI 10.2337/diabetes.49.4.633
   Kubota N, 2000, DIABETES, V49, P1880, DOI 10.2337/diabetes.49.11.1880
   Kubota N, 2008, CELL METAB, V8, P49, DOI 10.1016/j.cmet.2008.05.007
   Kuller LH, 1996, AM J EPIDEMIOL, V144, P537, DOI 10.1093/oxfordjournals.aje.a008963
   KUMON Y, 1994, CLIN BIOCHEM, V27, P469, DOI 10.1016/0009-9120(94)00044-V
   Kunz HE, 2021, AM J PHYSIOL-ENDOC M, V321, pE105, DOI 10.1152/ajpendo.00070.2021
   KUSHNER I, 1982, ANN NY ACAD SCI, V389, P39, DOI 10.1111/j.1749-6632.1982.tb22124.x
   Lee SH, 2022, DIABETES METAB J, V46, P15, DOI 10.4093/dmj.2021.0280
   Lee YH, 2003, J BIOL CHEM, V278, P2896, DOI 10.1074/jbc.M208359200
   Leinonen E, 2003, ATHEROSCLEROSIS, V166, P387, DOI 10.1016/S0021-9150(02)00371-4
   Leto D, 2012, NAT REV MOL CELL BIO, V13, P383, DOI 10.1038/nrm3351
   Li JJ, 2004, MED HYPOTHESES, V62, P499, DOI 10.1016/j.mehy.2003.12.014
   Liang XB, 2006, AM J PHYSIOL-ENDOC M, V290, pE103, DOI 10.1152/ajpendo.00605.2004
   Lijnen HR, 2005, J THROMB HAEMOST, V3, P35, DOI 10.1111/j.1538-7836.2004.00827.x
   Lijnen HR, 2005, J THROMB HAEMOST, V3, P1174, DOI 10.1111/j.1538-7836.2005.01390.x
   Lijnen HR, 2003, ARTERIOSCL THROM VAS, V23, P78, DOI 10.1161/01.ATV.0000044457.60665.DD
   Lin Y, 2001, J BIOL CHEM, V276, P42077, DOI 10.1074/jbc.M107101200
   López-Alemany R, 2003, EUR J BIOCHEM, V270, P814, DOI 10.1046/j.1432-1033.2003.03453.x
   LUCORE CL, 1988, J BIOL CHEM, V263, P15845
   Lyon CJ, 2003, AM J MED, V115, P62, DOI 10.1016/j.amjmed.2003.08.014
   Ma LJ, 2004, DIABETES, V53, P336, DOI 10.2337/diabetes.53.2.336
   Malle E, 1996, EUR J CLIN INVEST, V26, P427, DOI 10.1046/j.1365-2362.1996.159291.x
   Markanday A, 2015, OPEN FORUM INFECT DI, V2, DOI 10.1093/ofid/ofv098
   Marzi C, 2013, DIABETES CARE, V36, P1321, DOI 10.2337/dc12-1514
   Mathers CD, 2006, PLOS MED, V3, DOI 10.1371/journal.pmed.0030442
   McKay LI, 1998, MOL ENDOCRINOL, V12, P45, DOI 10.1210/mend.12.1.0044
   MCMILLAN DE, 1989, METABOLISM, V38, P1042, DOI 10.1016/0026-0495(89)90038-3
   MEEK RL, 1994, P NATL ACAD SCI USA, V91, P3186, DOI 10.1073/pnas.91.8.3186
   Mejhert N, 2022, NAT REV ENDOCRINOL, V18, P269, DOI 10.1038/s41574-022-00648-9
   Mendall MA, 1996, BRIT MED J, V312, P1061
   Meshkani R, 2009, CLIN BIOCHEM, V42, P1331, DOI 10.1016/j.clinbiochem.2009.05.018
   Mezza T, 2019, DIABETES, V68, P1121, DOI 10.2337/db18-0856
   Michael MD, 2000, MOL CELL, V6, P87, DOI 10.1016/S1097-2765(00)00010-1
   Miranda PJ, 2005, AM HEART J, V149, P33, DOI 10.1016/j.ahj.2004.07.013
   Miyake K, 2002, J CLIN INVEST, V110, P1483, DOI 10.1172/JCI200215880
   Mlinar B, 2007, CLIN CHIM ACTA, V375, P20, DOI 10.1016/j.cca.2006.07.005
   Mora A, 2005, BIOCHEM J, V385, P639, DOI 10.1042/BJ20041782
   Morange PE, 2002, THROMB HAEMOSTASIS, V87, P306
   Morange PE, 2000, ARTERIOSCL THROM VAS, V20, P1150, DOI 10.1161/01.ATV.20.4.1150
   Morange PE, 1999, DIABETES, V48, P890, DOI 10.2337/diabetes.48.4.890
   Moshage H, 1997, J PATHOL, V181, P257, DOI 10.1002/(SICI)1096-9896(199703)181:3<257::AID-PATH756>3.0.CO;2-U
   Muhammad IF, 2016, ACTA DIABETOL, V53, P981, DOI 10.1007/s00592-016-0903-8
   Mukai Y, 2007, AM J PHYSIOL-HEART C, V292, pH1937, DOI 10.1152/ajpheart.00868.2006
   Müller S, 2002, DIABETOLOGIA, V45, P805, DOI 10.1007/s00125-002-0829-2
   Ndumele Chiadi E, 2006, J Cardiometab Syndr, V1, P190
   Newton R, 2000, THORAX, V55, P603, DOI 10.1136/thorax.55.7.603
   Nieto-Vazquez Iria, 2008, Archives of Physiology and Biochemistry, V114, P183, DOI 10.1080/13813450802181047 
   Oguntibeju Oluwafemi Omoniyi, 2019, Int J Physiol Pathophysiol Pharmacol, V11, P45
   Oróstica L, 2020, REPROD SCI, V27, P290, DOI 10.1007/s43032-019-00026-3
   Padhi S, 2020, BIOMED PHARMACOTHER, V131, DOI 10.1016/j.biopha.2020.110708
   Pandey M, 2005, FASEB J, V19, P1317, DOI 10.1096/fj.04-3459fje
   Pasieka AM, 2016, METABOLITES, V6, DOI 10.3390/metabo6030024
   Pepys MB, 2003, J CLIN INVEST, V111, P1805, DOI 10.1172/JCI200318921
   Petersen MC, 2018, PHYSIOL REV, V98, P2133, DOI 10.1152/physrev.00063.2017
   Pickup JC, 1997, DIABETOLOGIA, V40, P1286, DOI 10.1007/s001250050822
   Pickup JC, 2004, DIABETES CARE, V27, P813, DOI 10.2337/diacare.27.3.813
   Pickup JC, 1998, DIABETOLOGIA, V41, P1241, DOI 10.1007/s001250051058
   Poitou C, 2005, DIABETOLOGIA, V48, P519, DOI 10.1007/s00125-004-1654-6
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Pratipanawatr W, 2001, DIABETES, V50, P2572, DOI 10.2337/diabetes.50.11.2572
   Qatanani M., 2010, GENE DEV, V36, P490, DOI [10.1101/gad.1550907.Adipokines, DOI 10.1101/GAD.1550907.ADIPOKINES]
   Qi D, 2007, AM J PHYSIOL-ENDOC M, V292, pE654, DOI 10.1152/ajpendo.00453.2006
   Qi YJ, 2013, DIABETES, V62, P3887, DOI 10.2337/db13-0095
   RAYNES JG, 1991, CLIN EXP IMMUNOL, V83, P488
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Rehman K, 2016, J BIOMED SCI, V23, DOI 10.1186/s12929-016-0303-y
   Reynolds RM, 2003, DIABETES OBES METAB, V5, P5, DOI 10.1046/j.1463-1326.2003.00221.x
   Rines AK, 2016, NAT REV DRUG DISCOV, V15, P786, DOI 10.1038/nrd.2016.151
   Ruzzin J, 2005, DIABETOLOGIA, V48, P2119, DOI 10.1007/s00125-005-1886-0
   SAAD MJA, 1993, J CLIN INVEST, V92, P2065, DOI 10.1172/JCI116803
   Sakamoto T, 1999, AM J PHYSIOL-CELL PH, V276, pC1391, DOI 10.1152/ajpcell.1999.276.6.C1391
   Sakoda H, 2000, DIABETES, V49, P1700, DOI 10.2337/diabetes.49.10.1700
   Saltiel AR, 2001, NATURE, V414, P799, DOI 10.1038/414799a
   Samad F, 1996, J CLIN INVEST, V97, P37, DOI 10.1172/JCI118404
   Samad F, 1996, MOL MED, V2, P568, DOI 10.1007/BF03401641
   SAWDEY MS, 1991, J CLIN INVEST, V88, P1346, DOI 10.1172/JCI115440
   Schäfer K, 2001, FASEB J, V15, P1840, DOI 10.1096/fj.00-0750fje
   Scheja L, 2008, EXP DIABETES RES, DOI 10.1155/2008/230837
   Schernthaner-Reiter MH, 2019, ENDOCRINE, V64, P157, DOI 10.1007/s12020-018-1819-6
   Schneider DJ, 2012, DIABETES CARE, V35, P1961, DOI 10.2337/dc12-0638
   Seki T, 1996, J CELL PHYSIOL, V168, P648
   Senn JJ, 2002, DIABETES, V51, P3391, DOI 10.2337/diabetes.51.12.3391
   Serrano R, 2009, AM J PHYSIOL-REG I, V297, pR1563, DOI 10.1152/ajpregu.00093.2009
   Severino C, 2002, AM J PHYSIOL-ENDOC M, V283, pE367, DOI 10.1152/ajpendo.00185.2001
   Sharabi K, 2015, MOL ASPECTS MED, V46, P21, DOI 10.1016/j.mam.2015.09.003
   Shim K, 2020, WORLD J DIABETES, V11, P1, DOI 10.4239/wjd.v11.i1.1
   SIPE JD, 1995, CLIN IMMUNOTHER, V3, P297, DOI 10.1007/BF03259281
   Sjöholm K, 2009, CYTOKINE, V48, P260, DOI 10.1016/j.cyto.2009.08.005
   SMITH JW, 1992, CLIN EXP IMMUNOL, V90, P293
   Sobel BE, 1998, CIRCULATION, V97, P2213, DOI 10.1161/01.CIR.97.22.2213
   Sommer G, 2008, J CELL BIOCHEM, V104, P2241, DOI 10.1002/jcb.21782
   Sproston NR, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.00754
   STEEL DM, 1991, BIOCHEM J, V277, P477, DOI 10.1042/bj2770477
   Stienstra R, 2007, PPAR RES, V2007, DOI 10.1155/2007/95974
   Su Q, 2018, PHARMACOL RES, V128, P145, DOI 10.1016/j.phrs.2017.09.012
   Suffredini AF, 1999, J CLIN IMMUNOL, V19, P203, DOI 10.1023/A:1020563913045
   Sun H, 2022, DIABETES RES CLIN PR, V183, DOI 10.1016/j.diabres.2021.109119
   Swaroop JJ, 2012, INDIAN J MED RES, V135, P127, DOI 10.4103/0971-5916.93435
   Swiatkowska M, 2002, CELL MOL BIOL LETT, V7, P1065
   Tamura Y, 2015, DIABETES, V64, P2194, DOI 10.2337/db14-1192
   Tamura Y, 2014, ENDOCRINOLOGY, V155, P1708, DOI 10.1210/en.2013-1888
   Tanti Jean-Francois, 2012, Front Endocrinol (Lausanne), V3, P181, DOI 10.3389/fendo.2012.00181
   Tarry-Adkins JL, 2021, DIABETES THER, V12, P1901, DOI 10.1007/s13300-021-01058-2
   Thorn CF, 2004, SCAND J IMMUNOL, V59, P152, DOI 10.1111/j.0300-9475.2004.01369.x
   Thorn CF, 2003, EUR J IMMUNOL, V33, P2630, DOI 10.1002/eji.200323985
   Thorn CF, 2002, J IMMUNOL, V169, P399, DOI 10.4049/jimmunol.169.1.399
   TILLETT WILLIAM S., 1930, JOUR EXP MED, V52, P561, DOI 10.1084/jem.52.4.561
   Uhlar CM, 1999, EUR J BIOCHEM, V265, P501, DOI 10.1046/j.1432-1327.1999.00657.x
   Uhlar CM, 1997, J IMMUNOL METHODS, V203, P123, DOI 10.1016/S0022-1759(96)00220-7
   Uysal KT, 1997, NATURE, V389, P610, DOI 10.1038/39335
   van Greevenbroek MMJ, 2013, NETH J MED, V71, P174
   Vincent HK, 2014, MED SCI SPORT EXER, V46, P1693, DOI 10.1249/MSS.0000000000000294
   Visser K, 2010, ENDOCRINOLOGY, V151, P5279, DOI 10.1210/en.2010-0368
   Wickert Lucia, 2007, Comp Hepatol, V6, P5
   Wilcox Gisela, 2005, Clin Biochem Rev, V26, P19
   Withers DJ, 1998, NATURE, V391, P900, DOI 10.1038/36116
   Xi LA, 2011, HEPATOLOGY, V53, P127, DOI 10.1002/hep.24011
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Xu JW, 2007, MOL ENDOCRINOL, V21, P564, DOI 10.1210/me.2006-0354
   Yamamoto K, 2002, P NATL ACAD SCI USA, V99, P890, DOI 10.1073/pnas.022608799
   Yang RZ, 2006, PLOS MED, V3, P884, DOI 10.1371/journal.pmed.0030287
   Ye JP, 2013, FRONT MED-PRC, V7, P14, DOI 10.1007/s11684-013-0262-6
   Ye XY, 2009, J ENDOCRINOL INVEST, V32, P568, DOI [10.1007/BF03346510, 10.3275/6111]
   YOUNG B, 1991, PATHOLOGY, V23, P118, DOI 10.3109/00313029109060809
   Yudkin JS, 1999, ARTERIOSCL THROM VAS, V19, P972, DOI 10.1161/01.ATV.19.4.972
   Zick Y, 2003, INT J OBESITY, V27, pS56, DOI 10.1038/sj.ijo.0802503
   INSULIN RESISTANCE S
NR 213
TC 15
Z9 16
U1 1
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD JUL
PY 2022
VL 11
IS 14
AR 2163
DI 10.3390/cells11142163
PG 20
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 3I1BJ
UT WOS:000832459800001
PM 35883605
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Arias-Loza, PA
   Muehlfelder, M
   Pelzer, T
AF Arias-Loza, Paula-Anahi
   Muehlfelder, Melanie
   Pelzer, Theo
TI Estrogen and estrogen receptors in cardiovascular oxidative stress
SO PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
LA English
DT Review
DE Estrogens; ROS; Oxidative stress; 17 beta-Estradiol; Cardiovascular
   system
ID NITRIC-OXIDE SYNTHASE; CEREBRAL BLOOD-VESSELS; MYOCARDIAL-INFARCTION;
   ENDOTHELIAL-CELLS; NADPH OXIDASES; OVARIECTOMIZED RATS; IN-VIVO;
   SUPEROXIDE GENERATION; GENDER-DIFFERENCES; METABOLIC SYNDROME
AB The cardiovascular system of a premenopausal woman is prepared to adapt to the challenges of increased cardiac output and work load that accompany pregnancy. Thus, it is tempting to speculate whether enhanced adaptability of the female cardiovascular system might be advantageous under conditions that promote cardiovascular disease. In support of this concept, 17 beta-estradiol as the major female sex hormone has been shown to confer protective cardiovascular effects in experimental studies. Mechanistically, these have been partially linked to the prevention and protection against oxidative stress. Current evidence indicates that estrogens attenuate oxidative stress at two levels: first, by preventing generation of reactive oxygen species (ROS) and, second, by scavenging ROS in the myocardium and in the vasculature. The purpose of this review is to give an overview on current concepts on conditions and mechanisms by which estrogens protect the cardiovascular system against ROS-mediated cellular injury.
C1 [Arias-Loza, Paula-Anahi; Muehlfelder, Melanie; Pelzer, Theo] Univ Hosp Wurzburg, Dept Internal Med 1, D-97080 Wurzburg, Germany.
   [Pelzer, Theo] Univ Hosp Wurzburg, Dept Med Cardiol & Pneumol ZIM 1, D-97080 Wurzburg, Germany.
C3 University of Wurzburg; University of Wurzburg
RP Pelzer, T (corresponding author), Univ Hosp Wurzburg, Dept Med Cardiol & Pneumol ZIM 1, Oberduerrbacher Str 6, D-97080 Wurzburg, Germany.
EM pelzer_t@klinik.uni-wuerzburg.de
OI Arias-Loza, Anahi-Paula/0000-0003-4048-4719
FU Interdisciplinary Center for Clinical Research Wurzburg [Z-2/21, F-144];
   Comprehensive Heart Failure Center Wurzburg [CHFC D-5]; Bayer Pharma AG
   Berlin
FX T.P. received support from the Interdisciplinary Center for Clinical
   Research Wurzburg (Z-2/21 and F-144) and the Comprehensive Heart Failure
   Center Wurzburg (CHFC D-5).T.P. has received financial support from the
   Bayer Pharma AG Berlin that relates to the evaluation of novel steroid
   hormone receptor ligands.
CR Alderton WK, 2001, BIOCHEM J, V357, P593, DOI 10.1042/0264-6021:3570593
   Altenhöfer S, 2012, CELL MOL LIFE SCI, V69, P2327, DOI 10.1007/s00018-012-1010-9
   Arias-Loza PA, 2011, TOXICOL PATHOL, V39, P867, DOI 10.1177/0192623311410441
   Barbacanne MA, 1999, CARDIOVASC RES, V41, P672, DOI 10.1016/S0008-6363(98)00254-5
   Bäumer AT, 2001, BRIT J PHARMACOL, V134, P579, DOI 10.1038/sj.bjp.0704299
   Booth EA, 2007, AM J PHYSIOL-HEART C, V293, pH1408, DOI 10.1152/ajpheart.00993.2006
   Borrás C, 2010, BBA-MOL BASIS DIS, V1802, P205, DOI 10.1016/j.bbadis.2009.09.007
   BRILLA CG, 1992, J LAB CLIN MED, V120, P893
   Busserolles J, 2002, EXP BIOL MED, V227, P837, DOI 10.1177/153537020222700918
   Cavasin MA, 2003, AM J PHYSIOL-HEART C, V284, pH1560, DOI 10.1152/ajpheart.01087.2002
   Crabbe DL, 2003, J AM COLL CARDIOL, V41, P300, DOI 10.1016/S0735-1097(02)02710-9
   Dean SA, 2006, AM J PHYSIOL-REG I, V291, pR155, DOI 10.1152/ajpregu.00497.2005
   Deschamps AM, 2010, TRENDS CARDIOVAS MED, V20, P73, DOI 10.1016/j.tcm.2010.05.001
   Ejima K, 1999, EUR J ENDOCRINOL, V140, P608, DOI 10.1530/eje.0.1400608
   Florian M, 2004, STEROIDS, V69, P779, DOI 10.1016/j.steroids.2004.09.008
   Foryst-Ludwig A, 2010, J STEROID BIOCHEM, V122, P74, DOI 10.1016/j.jsbmb.2010.06.012
   Furchgott RF, 1999, BIOSCIENCE REP, V19, P235, DOI 10.1023/A:1020537506008
   Gragasin FS, 2003, ARTERIOSCL THROM VAS, V23, P38, DOI 10.1161/01.ATV.0000047868.93732.B7
   GRIENDLING KK, 1994, CIRC RES, V74, P1141, DOI 10.1161/01.RES.74.6.1141
   Griendling KK, 2003, CIRCULATION, V108, P1912, DOI 10.1161/01.CIR.0000093660.86242.BB
   Hayward CS, 2000, CARDIOVASC RES, V46, P28, DOI 10.1016/S0008-6363(00)00005-5
   Hernández I, 2000, AM J PHYSIOL-REG I, V279, pR1599, DOI 10.1152/ajpregu.2000.279.5.R1599
   Javeshghani D, 2009, J AM SOC HYPERTENS, V3, P295, DOI 10.1016/j.jash.2009.07.002
   Jazbutyte V, 2009, BIOCHEM BIOPH RES CO, V384, P450, DOI 10.1016/j.bbrc.2009.04.139
   Jeanes HL, 2008, J ENDOCRINOL, V197, P493, DOI 10.1677/JOE-08-0071
   Jeong EM, 2012, J MOL CELL CARDIOL, V52, P454, DOI 10.1016/j.yjmcc.2011.09.018
   KANNEL WB, 1976, ANN INTERN MED, V85, P447, DOI 10.7326/0003-4819-85-4-447
   KAUSER K, 1994, AM J PHYSIOL-HEART C, V267, pH2311, DOI 10.1152/ajpheart.1994.267.6.H2311
   Kim JK, 2006, J BIOL CHEM, V281, P6760, DOI 10.1074/jbc.M511024200
   Lagranha CJ, 2010, CIRC RES, V106, P1681, DOI 10.1161/CIRCRESAHA.109.213645
   Lam KK, 2006, MENOPAUSE, V13, P294, DOI 10.1097/01.gme.0000182806.99137.5e
   Lassègue B, 2012, CIRC RES, V110, P1364, DOI 10.1161/CIRCRESAHA.111.243972
   Laufs U, 2003, J BIOL CHEM, V278, P5956, DOI 10.1074/jbc.M209813200
   Li JM, 2004, AM J PHYSIOL-REG I, V287, pR1014, DOI 10.1152/ajpregu.00124.2004
   Li L, 2007, P NATL ACAD SCI USA, V104, P16468, DOI 10.1073/pnas.0704315104
   McNeill AM, 1999, STROKE, V30, P2186, DOI 10.1161/01.STR.30.10.2186
   Mendelsohn ME, 2005, SCIENCE, V308, P1583, DOI 10.1126/science.1112062
   Mendelsohn ME, 1999, NEW ENGL J MED, V340, P1801, DOI 10.1056/NEJM199906103402306
   Moreau KL, 2012, AM J PHYSIOL-HEART C, V302, pH1211, DOI 10.1152/ajpheart.01065.2011
   Muehlfelder M, 2012, BIOCHEM BIOPH RES CO, V423, P850, DOI 10.1016/j.bbrc.2012.06.053
   Murase T, 2012, HYPERTENSION, V59, P694, DOI 10.1161/HYPERTENSIONAHA.111.180976
   Nickenig G, 1998, CIRCULATION, V97, P2197, DOI 10.1161/01.CIR.97.22.2197
   Ortmann J, 2011, J CLIN ENDOCR METAB, V96, P220, DOI 10.1210/jc.2010-0943
   Paravicini TM, 2008, DIABETES CARE, V31, pS170, DOI 10.2337/dc08-s247
   Perjés A, 2012, ACTA PHYSIOL, V205, P26, DOI 10.1111/j.1748-1716.2012.02391.x
   Poornima IG, 2006, CIRC RES, V98, P596, DOI 10.1161/01.RES.0000207406.94146.c2
   Raedschelders K, 2012, PHARMACOL THERAPEUT, V133, P230, DOI 10.1016/j.pharmthera.2011.11.004
   Razmara A, 2008, J PHARMACOL EXP THER, V325, P782, DOI 10.1124/jpet.107.134072
   Schramm A, 2012, VASC PHARMACOL, V56, P216, DOI 10.1016/j.vph.2012.02.012
   Smith PJW, 2000, CIRCULATION, V102, P2983
   Sovershaev MA, 2006, AM J PHYSIOL-HEART C, V291, pH1554, DOI 10.1152/ajpheart.01171.2005
   Stirone C, 2005, MOL PHARMACOL, V67, P105, DOI 10.1124/mol.104.004465
   Stirone C, 2003, EUR J PHARMACOL, V478, P35, DOI 10.1016/j.ejphar.2003.08.037
   Strehlow K, 2003, CIRC RES, V93, P170, DOI 10.1161/01.RES.0000082334.17947.11
   Szabó C, 2003, TOXICOL LETT, V140, P105, DOI 10.1016/S0378-4274(02)00507-6
   TIMMERMANS PBMWM, 1993, PHARMACOL REV, V45, P205
   Tomaschitz A, 2010, EUR HEART J, V31, P1237, DOI 10.1093/eurheartj/ehq019
   Tschudi MR, 1996, HYPERTENSION, V27, P32, DOI 10.1161/01.HYP.27.1.32
   Urata Y, 2006, J BIOL CHEM, V281, P13092, DOI 10.1074/jbc.M601984200
   Vásquez-Vivar J, 1998, P NATL ACAD SCI USA, V95, P9220, DOI 10.1073/pnas.95.16.9220
   Wagner AH, 2001, FASEB J, V15, P2121, DOI 10.1096/fj.01-0123com
   Wassmann S, 2002, CIRCULATION, V105, P2083, DOI 10.1161/01.CIR.0000014618.91633.67
   Wing LYC, 2009, EXP BIOL MED, V234, P1037, DOI 10.3181/0811-RM-332
   Wong CM, 2008, BRIT J PHARMACOL, V155, P326, DOI 10.1038/bjp.2008.262
   Yang SH, 2004, P NATL ACAD SCI USA, V101, P4130, DOI 10.1073/pnas.0306948101
   Yung LM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017437
   Zhang L, 2007, J HYPERTENS, V25, P407, DOI 10.1097/HJH.0b013e328010beee
   Zhang YX, 2012, FREE RADICAL BIO MED, V53, P1531, DOI 10.1016/j.freeradbiomed.2012.07.010
NR 68
TC 57
Z9 63
U1 1
U2 29
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0031-6768
J9 PFLUG ARCH EUR J PHY
JI Pflugers Arch.
PD MAY
PY 2013
VL 465
IS 5
BP 739
EP 746
DI 10.1007/s00424-013-1247-7
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 143MO
UT WOS:000318871800015
PM 23417608
DA 2025-06-11
ER

PT S
AU Naito, Y
   Yoshikawa, T
AF Naito, Yuji
   Yoshikawa, Toshikazu
BE Yoshikawa, T
TI Oxidative Stress-induced Posttranslational Modification of Proteins as a
   Target of Functional Food
SO FOOD FACTORS FOR HEALTH PROMOTION
SE Forum of Nutrition
LA English
DT Article; Book Chapter
ID MANGANESE-SUPEROXIDE-DISMUTASE; ACID-BINDING PROTEIN;
   LIPID-PEROXIDATION; 4-HYDROXY-2-NONENAL-MODIFIED PROTEINS; THIOREDOXIN
   REDUCTASE; MEDIATED NITRATION; MONOCLONAL-ANTIBODY; INSULIN-RESISTANCE;
   RAT MODEL; IN-VITRO
AB In lifestyle-related diseases including metabolic syndrome, atherosclerosis, and cancer, oxidative stress is indicated by several markers, among which are lipid peroxides, aldehydes, and nitrotyrosine. We hypothesized that identification of proteins that are posttranslationally modified due to oxidative stress would lead to a greater understanding of some of the potential molecular mechanisms involved in degeneration and inflammation in these disorders. Proteomics is an emerging method for identification of proteins and their modification residues, and its application to food factor science is just beginning. Especially, we can obtain several monoclonal antibodies to detect specifically oxidized proteins, which can be applied to analysis by immunostaining or immunoblot. In this review, we present the use of these monoclonal antibodies in several diseases, from which new insights have emerged into mechanisms of metabolism and inflammation in these disorders that are associated with oxidative stress. Copyright (C) 2009 S. Karger AG, Basel
C1 [Naito, Yuji] Kyoto Prefectural Univ Med, Kamigyo Ku, Kyoto 6028566, Japan.
C3 Kyoto Prefectural University of Medicine
RP Naito, Y (corresponding author), Kyoto Prefectural Univ Med, Kamigyo Ku, Kyoto 6028566, Japan.
EM ynaito@koto.kpu-m.ac.jp
RI Naito, Yuji/D-1213-2010
FU Grants-in-Aid for Scientific Research [21390184] Funding Source: KAKEN
CR Ahsan H, 2003, CLIN EXP IMMUNOL, V131, P398, DOI 10.1046/j.1365-2249.2003.02104.x
   Anantharaman M, 2006, AM J PATHOL, V168, P1608, DOI 10.2353/ajpath.2006.051223
   Aoi W, 2003, ANTIOXID REDOX SIGN, V5, P139, DOI 10.1089/152308603321223630
   Aoi W, 2008, BIOCHEM BIOPH RES CO, V366, P892, DOI 10.1016/j.bbrc.2007.12.019
   Bayir H, 2007, J NEUROCHEM, V101, P168, DOI 10.1111/j.1471-4159.2006.04353.x
   Bennaars-Eiden A, 2002, J BIOL CHEM, V277, P50693, DOI 10.1074/jbc.M209493200
   Betteridge DJ, 2000, METABOLISM, V49, P3, DOI 10.1016/S0026-0495(00)80077-3
   BLASIG IE, 1995, AM J PHYSIOL-HEART C, V269, pH14, DOI 10.1152/ajpheart.1995.269.1.H14
   Carbone DL, 2005, J PHARMACOL EXP THER, V315, P8, DOI 10.1124/jpet.105.088088
   Cassidy PB, 2006, CARCINOGENESIS, V27, P2538, DOI 10.1093/carcin/bgl111
   Chang MK, 2004, J EXP MED, V200, P1359, DOI 10.1084/jem.20031763
   Chou MY, 2008, J INTERN MED, V263, P479, DOI 10.1111/j.1365-2796.2008.01968.x
   Cloos PAC, 2004, BIOGERONTOLOGY, V5, P139, DOI 10.1023/B:BGEN.0000031152.31352.8b
   Devaraj S, 2008, FREE RADICAL BIO MED, V44, P1203, DOI 10.1016/j.freeradbiomed.2007.12.018
   Eaton P, 2002, J BIOL CHEM, V277, P9806, DOI 10.1074/jbc.M111454200
   Eschwège P, 1999, J UROLOGY, V162, P553, DOI 10.1016/S0022-5347(05)68626-0
   Fang JG, 2006, J AM CHEM SOC, V128, P1879, DOI 10.1021/ja057358l
   Fukuchi Y, 2008, J ATHEROSCLER THROMB, V15, P185, DOI 10.5551/jat.E543
   Grimsrud PA, 2007, MOL CELL PROTEOMICS, V6, P624, DOI 10.1074/mcp.M600120-MCP200
   Gujral Jaspreet S, 2004, Comp Hepatol, V3 Suppl 1, pS48, DOI 10.1186/1476-5926-2-S1-S48
   Hartley DP, 1997, CHEM RES TOXICOL, V10, P895, DOI 10.1021/tx960181b
   HEINECKE JW, 2008, J LIPID RES
   Ihara Y, 1999, DIABETES, V48, P927, DOI 10.2337/diabetes.48.4.927
   Ishii T, 2005, BIOCHEMISTRY-US, V44, P13893, DOI 10.1021/bi051336u
   Ishii T, 2004, CHEM RES TOXICOL, V17, P1313, DOI 10.1021/tx049860+
   Kageyama F, 2000, AM J GASTROENTEROL, V95, P1041, DOI 10.1111/j.1572-0241.2000.01979.x
   Kato Y, 1999, J BIOL CHEM, V274, P20406, DOI 10.1074/jbc.274.29.20406
   Kato Y, 2000, BIOCHEM BIOPH RES CO, V274, P389, DOI 10.1006/bbrc.2000.3150
   Kovacic P, 2003, MINI-REV MED CHEM, V3, P568, DOI 10.2174/1389557033487926
   Kruger AL, 2006, J PHARMACOL EXP THER, V319, P1144, DOI 10.1124/jpet.106.107482
   Kunitomo M, 2008, J PHARMACOL SCI, V107, P128, DOI 10.1254/jphs.FP0072365
   Kuster GM, 2006, ANTIOXID REDOX SIGN, V8, P2153, DOI 10.1089/ars.2006.8.2153
   MacMillan-Crow LA, 1998, BIOCHEMISTRY-US, V37, P1613, DOI 10.1021/bi971894b
   Manabe E, 2008, J CELL BIOCHEM, V103, P1925, DOI 10.1002/jcb.21583
   Mark RJ, 1997, J NEUROSCI, V17, P1046
   Miyake H, 2003, BIOL PHARM BULL, V26, P1652, DOI 10.1248/bpb.26.1652
   Musso G, 2007, AM J CLIN NUTR, V86, P661, DOI 10.1093/ajcn/86.3.661
   Nair J, 2006, ANTIOXID REDOX SIGN, V8, P1003, DOI 10.1089/ars.2006.8.1003
   Naito Y., 2005, Current Drug Targets - Inflammation and Allergy, V4, P511, DOI 10.2174/1568010054526269
   Naito Y, 2004, BIOFACTORS, V20, P49, DOI 10.1002/biof.5520200105
   Osakabe N, 2002, FREE RADICAL BIO MED, V33, P798, DOI 10.1016/S0891-5849(02)00970-X
   Park YS, 2005, BIOCHEM BIOPH RES CO, V327, P1058, DOI 10.1016/j.bbrc.2004.12.104
   Park YS, 2003, FREE RADICAL RES, V37, P205, DOI 10.1080/1071576021000041005
   Perluigi M, 2005, FREE RADICAL BIO MED, V38, P960, DOI 10.1016/j.freeradbiomed.2004.12.021
   Reed T, 2008, NEUROBIOL DIS, V30, P107, DOI 10.1016/j.nbd.2007.12.007
   Rhee SG, 2006, SCIENCE, V312, P1882, DOI 10.1126/science.1130481
   Ryu JK, 2007, GLIA, V55, P439, DOI 10.1002/glia.20479
   Saitoh T, 2008, NATURE, V456, P264, DOI 10.1038/nature07383
   Selley ML, 1998, FREE RADICAL BIO MED, V25, P169, DOI 10.1016/S0891-5849(98)00021-5
   Serviddio G, 2008, GUT, V57, P957, DOI 10.1136/gut.2007.147496
   Shao BH, 2006, J BIOL CHEM, V281, P9001, DOI 10.1074/jbc.C600011200
   Tangpong J, 2007, J NEUROCHEM, V100, P191, DOI 10.1111/j.1471-4159.2006.04179.x
   Toyoda K, 2007, J BIOL CHEM, V282, P25769, DOI 10.1074/jbc.M703039200
   TOYOKUNI S, 1995, FEBS LETT, V359, P189, DOI 10.1016/0014-5793(95)00033-6
   TOYOKUNI S, 1994, P NATL ACAD SCI USA, V91, P2616, DOI 10.1073/pnas.91.7.2616
   Trigwell SM, 2001, CLIN EXP IMMUNOL, V126, P242, DOI 10.1046/j.1365-2249.2001.01653.x
   Uchida K, 2005, J CLIN BIOCHEM NUTR, V36, P1, DOI 10.3164/jcbn.36.1
   UCHIDA K, 1994, BIOCHEMISTRY-US, V33, P12487, DOI 10.1021/bi00207a016
   Winterbourn CC, 2000, FREE RADICAL BIO MED, V29, P403, DOI 10.1016/S0891-5849(00)00204-5
   Yamagami K, 2000, ANTIOXID REDOX SIGN, V2, P127, DOI 10.1089/ars.2000.2.1-127
   Yamaguchi Y, 2006, LIFE SCI, V79, P2474, DOI 10.1016/j.lfs.2006.08.007
   Yamakura F, 1998, J BIOL CHEM, V273, P14085, DOI 10.1074/jbc.273.23.14085
   Yang JH, 2004, FREE RADICAL RES, V38, P241, DOI 10.1080/10715760310001657712
   Yasuda A, 2008, INT J IMMUNOPATH PH, V21, P279, DOI 10.1177/039463200802100204
   Yeo WS, 2008, BMB REP, V41, P194, DOI 10.5483/BMBRep.2008.41.3.194
NR 65
TC 6
Z9 6
U1 0
U2 3
PU KARGER
PI BASEL
PA POSTFACH, CH-4009 BASEL, SWITZERLAND
SN 1660-0347
BN 978-3-8055-9097-6
J9 FORUM NUTR
JI Forum Nutr.
PY 2009
VL 61
BP 39
EP 54
DI 10.1159/000212737
PG 16
WC Nutrition & Dietetics
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA BKJ08
UT WOS:000268245400004
PM 19367109
DA 2025-06-11
ER

PT J
AU Boudina, S
AF Boudina, Sihem
TI Cardiac Aging and Insulin Resistance: Could Insulin/Insulin-Like Growth
   Factor (IGF) Signaling be used as a Therapeutic Target?
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Insulin signaling; cardiac function; cardiac aging; mitochondria;
   reactive oxygen species; autophagy; fibrosis
ID AGE-RELATED-CHANGES; RAT-HEART MITOCHONDRIA; CARDIOVASCULAR-DISEASE
   ENTERPRISES; MANGANESE SUPEROXIDE-DISMUTASE; ENDOPLASMIC-RETICULUM
   STRESS; OXIDATIVE STRESS; ELECTRON-TRANSPORT; PERMEABILITY TRANSITION;
   ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME
AB Intrinsic cardiac aging is an independent risk factor for cardiovascular disease and is associated with structural and functional changes that impede cardiac responses to stress and to cardio-protective mechanisms. Although systemic insulin resistance and the associated risk factors exacerbate cardiac aging, cardiac-specific insulin resistance without confounding systemic alterations, could prevent cardiac aging. Thus, strategies aimed to reduce insulin/insulin-like growth factor (IGF) signaling in the heart prevent cardiac aging in lower organisms and in mammals but the mechanisms underlying this protection are not fully understood. In this review, we describe the impact of aging on the cardiovascular system and discuss the mounting evidence that reduced insulin/IGF signaling in the heart could alleviate age-associated alterations and preserve cardiac performance.
C1 [Boudina, Sihem] Univ Utah, Sch Med, Div Endocrinol Metab & Diabet, Salt Lake City, UT 84112 USA.
   [Boudina, Sihem] Univ Utah, Sch Med, Program Mol Med, Salt Lake City, UT 84112 USA.
C3 Utah System of Higher Education; University of Utah; Utah System of
   Higher Education; University of Utah
RP Boudina, S (corresponding author), Program Human Mol Biol & Genet, Div Endocrinol Metab & Diabet, 15 N 2030 Bldg 533 Rm 3410B, Salt Lake City, UT 84112 USA.
EM sihem.boudina@hmbg.utah.edu
FU American Heart Association [09SDG2220218]; National Institutes of Health
   (NIH) [P30-HL-101310]; American Heart Association (AHA) [09SDG2220218]
   Funding Source: American Heart Association (AHA)
FX This work was supported by grants 09SDG2220218 from the American Heart
   Association and P30-HL-101310 from the National Institutes of Health
   (NIH) to Sihem Boudina. S.B. researched the literature, wrote,
   constructed and edited the manuscript.
CR Ago T, 2010, AGING-US, V2, P1012, DOI 10.18632/aging.100261
   Alcendor RR, 2007, CIRC RES, V100, P1512, DOI 10.1161/01.RES.0000267723.65696.4a
   Aranda R, 2007, FREE RADICAL RES, V41, P1195, DOI 10.1080/10715760701481461
   Asai K, 2000, ARTERIOSCL THROM VAS, V20, P1493, DOI 10.1161/01.ATV.20.6.1493
   Atkinson J, 2008, J APPL PHYSIOL, V105, P1643, DOI 10.1152/japplphysiol.90476.2008
   Barazzoni R, 2000, J BIOL CHEM, V275, P3343, DOI 10.1074/jbc.275.5.3343
   Bartling B, 2003, FEBS LETT, V555, P539, DOI 10.1016/s0014-5793(03)01342-5
   Belfiore A, 2009, ENDOCR REV, V30, P586, DOI 10.1210/er.2008-0047
   Belke DD, 2002, J CLIN INVEST, V109, P629, DOI 10.1172/JCI200213946
   BELMIN J, 1993, AM J PHYSIOL, V264, pH679, DOI 10.1152/ajpheart.1993.264.3.H679
   BENEDETTI MS, 1994, J NEURAL TRANSM-SUPP, P83
   BENJAMIN EJ, 1992, AM J CARDIOL, V70, P508, DOI 10.1016/0002-9149(92)91199-E
   Blakesley Vicky A., 1996, Cytokine and Growth Factor Reviews, V7, P153, DOI 10.1016/1359-6101(96)00015-9
   Boudina S, 2009, CIRCULATION, V119, P1272, DOI 10.1161/CIRCULATIONAHA.108.792101
   Boyle AJ, 2011, EXP GERONTOL, V46, P549, DOI 10.1016/j.exger.2011.02.010
   Bulteau AL, 2002, ARCH BIOCHEM BIOPHYS, V397, P298, DOI 10.1006/abbi.2001.2663
   BURNET FM, 1973, LANCET, V2, P480
   Butler J, 2006, J AM COLL CARDIOL, V47, P1595, DOI 10.1016/j.jacc.2005.12.046
   CANO J, 1984, EXPERIENTIA, V40, P206, DOI 10.1007/BF01963602
   Chaudhary KR, 2011, J GERIATR CARDIOL, V8, P159, DOI 10.3724/SP.J.1263.2011.00159
   Chen Q, 2003, J BIOL CHEM, V278, P36027, DOI 10.1074/jbc.M304854200
   Chen W, 2010, HEART FAIL REV, V15, P415, DOI 10.1007/s10741-010-9161-y
   Chinnaiyan KM, 2007, AM HEART J, V153, P189, DOI 10.1016/j.ahj.2006.10.022
   Choksi KB, 2011, AGING-US, V3, P754, DOI 10.18632/aging.100357
   Correia LCL, 2002, J AM COLL CARDIOL, V40, P1290, DOI 10.1016/S0735-1097(02)02132-0
   CORTOPASSI GA, 1990, NUCLEIC ACIDS RES, V18, P6927, DOI 10.1093/nar/18.23.6927
   Crompton M, 2004, AGING CELL, V3, P3, DOI 10.1046/j.1474-9728.2003.00073.x
   Dai DF, 2012, CIRC RES, V110, P1109, DOI 10.1161/CIRCRESAHA.111.246140
   Dai DF, 2010, AGING CELL, V9, P536, DOI 10.1111/j.1474-9726.2010.00581.x
   Dai DF, 2009, CIRCULATION, V119, P2789, DOI 10.1161/CIRCULATIONAHA.108.822403
   Davies SMK, 2001, FREE RADICAL BIO MED, V31, P181, DOI 10.1016/S0891-5849(01)00576-7
   de Souza RR, 2002, BIOGERONTOLOGY, V3, P325, DOI 10.1023/A:1021312027486
   de Souza-Pinto NC, 2001, FREE RADICAL BIO MED, V30, P916, DOI 10.1016/S0891-5849(01)00483-X
   Debessa CRG, 2001, MECH AGEING DEV, V122, P1049
   Demissie S, 2006, AGING CELL, V5, P325, DOI 10.1111/j.1474-9726.2006.00224.x
   Di Lisa F, 2005, CARDIOVASC RES, V66, P222, DOI 10.1016/j.cardiores.2005.02.009
   Dutta D, 2012, CIRC RES, V110, P1125, DOI 10.1161/CIRCRESAHA.111.246108
   Edgar D, 2009, CELL METAB, V10, P131, DOI 10.1016/j.cmet.2009.06.010
   Fannin SW, 1999, ARCH BIOCHEM BIOPHYS, V372, P399, DOI 10.1006/abbi.1999.1508
   Ferrari AU, 2003, J APPL PHYSIOL, V95, P2591, DOI 10.1152/japplphysiol.00601.2003
   Finley LWS, 2009, AGEING RES REV, V8, P173, DOI 10.1016/j.arr.2009.03.003
   FLEG JL, 1994, CIRCULATION, V90, P2333, DOI 10.1161/01.CIR.90.5.2333
   FLEG JL, 1995, J APPL PHYSIOL, V78, P890, DOI 10.1152/jappl.1995.78.3.890
   Fontes JD, 2012, AM J CARDIOL, V109, P87, DOI 10.1016/j.amjcard.2011.08.008
   FRATICELLI A, 1989, AM J PHYSIOL, V257, pH259, DOI 10.1152/ajpheart.1989.257.1.H259
   Fu HY, 2010, CIRCULATION, V122, P361, DOI 10.1161/CIRCULATIONAHA.109.917914
   Gottlieb RA, 2010, AM J PHYSIOL-CELL PH, V299, pC203, DOI 10.1152/ajpcell.00097.2010
   Gounder SS, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0045697
   GUERRIERI F, 1992, ARCH GERONTOL GERIAT, V14, P299, DOI 10.1016/0167-4943(92)90029-4
   Hafner AV, 2010, AGING-US, V2, P914, DOI 10.18632/aging.100252
   Han S, 2006, CELL METAB, V3, P257, DOI 10.1016/j.cmet.2006.02.008
   HAYAKAWA M, 1993, MOL CELL BIOCHEM, V119, P95, DOI 10.1007/BF00926859
   HONGO K, 1988, STROKE, V19, P892, DOI 10.1161/01.STR.19.7.892
   Horn MA, 2012, J MOL CELL CARDIOL, V53, P82, DOI 10.1016/j.yjmcc.2012.03.011
   Hu P, 2003, AM J PHYSIOL-HEART C, V285, pH1261, DOI 10.1152/ajpheart.00108.2003
   Hu YF, 2010, ACTA CARDIOL, V65, P653, DOI 10.1080/AC.65.6.2059862
   Hua YN, 2011, BASIC RES CARDIOL, V106, P1173, DOI 10.1007/s00395-011-0222-8
   Ide T, 1999, CIRC RES, V85, P357, DOI 10.1161/01.RES.85.4.357
   Inuzuka Y, 2009, CIRCULATION, V120, P1695, DOI 10.1161/CIRCULATIONAHA.109.871137
   Jahangir A, 2001, MECH AGEING DEV, V122, P1073, DOI 10.1016/S0047-6374(01)00242-1
   Judge S, 2005, FASEB J, V19, P419, DOI 10.1096/fj.04-2622fje
   Judge S, 2007, AM J PHYSIOL-CELL PH, V292, pC1983, DOI 10.1152/ajpcell.00285.2006
   Juhaszova M, 2005, CARDIOVASC RES, V66, P233, DOI 10.1016/j.cardiores.2004.12.020
   Kalogeropoulos A, 2009, J CARD FAIL, V15, P593, DOI 10.1016/j.cardfail.2009.03.001
   Kannel William B, 2002, Am J Geriatr Cardiol, V11, P101, DOI 10.1111/j.1076-7460.2002.00995.x
   Kates AM, 2003, J AM COLL CARDIOL, V41, P293, DOI 10.1016/S0735-1097(02)02714-6
   KELBAEK H, 1991, SCAND J CLIN LAB INV, V51, P161, DOI 10.3109/00365519109091103
   Kenyon C, 2005, CELL, V120, P449, DOI 10.1016/j.cell.2005.02.002
   Kim JH, 2009, J APPL PHYSIOL, V107, P1249, DOI 10.1152/japplphysiol.91393.2008
   Kim J, 2008, MOL ENDOCRINOL, V22, P2531, DOI 10.1210/me.2008-0265
   KIM JH, 1988, MECH AGEING DEV, V46, P279, DOI 10.1016/0047-6374(88)90130-3
   Koonen DPY, 2007, CIRCULATION, V116, P2139, DOI 10.1161/CIRCULATIONAHA.107.712901
   Kostin S, 2003, CIRC RES, V92, P715, DOI 10.1161/01.RES.0000067471.95890.5C
   Kujoth GC, 2005, SCIENCE, V309, P481, DOI 10.1126/science.1112125
   Laakso M, 1996, CURR OPIN LIPIDOL, V7, P217, DOI 10.1097/00041433-199608000-00008
   Lakatta EG, 2003, CIRCULATION, V107, P139, DOI 10.1161/01.CIR.0000048892.83521.58
   Lakatta EG, 2000, CLIN GERIATR MED, V16, P419, DOI 10.1016/S0749-0690(05)70021-5
   Lakatta EG, 2001, CIRC RES, V88, P984, DOI 10.1161/hh1001.091963
   LAMMIKEEFE CJ, 1984, GERONTOLOGY, V30, P153, DOI 10.1159/000212623
   Larsson NG, 2010, ANNU REV BIOCHEM, V79, P683, DOI 10.1146/annurev-biochem-060408-093701
   Laustsen PG, 2007, MOL CELL BIOL, V27, P1649, DOI 10.1128/MCB.01110-06
   Lee TM, 2002, CIRCULATION, V105, P334, DOI 10.1161/hc0302.102572
   LeMoine CMR, 2006, BIOCHEM CELL BIOL, V84, P191, DOI 10.1139/O05-169
   Lempiäinen P, 1999, CIRCULATION, V100, P123, DOI 10.1161/01.CIR.100.2.123
   Lesnefsky EJ, 2001, J MOL CELL CARDIOL, V33, P37, DOI 10.1006/jmcc.2000.1273
   Leung AWC, 2008, BBA-BIOENERGETICS, V1777, P946, DOI 10.1016/j.bbabio.2008.03.009
   Li F, 2008, MECH AGEING DEV, V129, P515, DOI 10.1016/j.mad.2008.04.007
   Li QX, 2009, BASIC RES CARDIOL, V104, P269, DOI 10.1007/s00395-008-0754-8
   Li Q, 2008, REJUV RES, V11, P725, DOI 10.1089/rej.2008.0717
   Li Q, 2007, AM J PHYSIOL-HEART C, V292, pH1398, DOI 10.1152/ajpheart.01036.2006
   Lin J, 2008, EXP GERONTOL, V43, P296, DOI 10.1016/j.exger.2007.12.005
   LINNANE AW, 1989, LANCET, V1, P642, DOI 10.1016/S0140-6736(89)92145-4
   Ljubicic V, 2010, MECH AGEING DEV, V131, P79, DOI 10.1016/j.mad.2009.12.004
   Maggi S, 2006, J GERONTOL A-BIOL, V61, P505, DOI 10.1093/gerona/61.5.505
   Maklashina E, 2004, AGING CELL, V3, P21, DOI 10.1111/j.1474-9728.2003.00078.x
   MANZELMANN MS, 1987, MECH AGEING DEV, V39, P281, DOI 10.1016/0047-6374(87)90067-4
   Marín-García J, 2002, J CARD FAIL, V8, P347, DOI 10.1054/jcaf.2002.127774
   MARON BJ, 1975, AM J PATHOL, V79, P387
   Martinet W, 2009, CIRC RES, V104, P304, DOI 10.1161/CIRCRESAHA.108.188318
   Maurel A, 2003, AM J PHYSIOL-HEART C, V284, pH1460, DOI 10.1152/ajpheart.00700.2002
   MCMILLIN JB, 1993, CARDIOVASC RES, V27, P2222, DOI 10.1093/cvr/27.12.2222
   MECO M, 1987, MECH AGEING DEV, V38, P145, DOI 10.1016/0047-6374(87)90074-1
   Minamino T, 2010, CIRC RES, V107, P1071, DOI 10.1161/CIRCRESAHA.110.227819
   Minamino T, 2010, J MOL CELL CARDIOL, V48, P1105, DOI 10.1016/j.yjmcc.2009.10.026
   Moellendorf S, 2012, AM J PHYSIOL-ENDOC M, V303, pE213, DOI 10.1152/ajpendo.00538.2011
   Moslehi J, 2012, CIRC RES, V110, P1226, DOI 10.1161/CIRCRESAHA.111.246868
   Nagai Y, 1999, VASC MED, V4, P181, DOI 10.1177/1358836X9900400309
   Nakai A, 2007, NAT MED, V13, P619, DOI 10.1038/nm1574
   Nassimiha D, 2001, AM J CARDIOL, V87, P1313, DOI 10.1016/S0002-9149(01)01531-4
   Niizuma S, 2012, LIFE SCI, V90, P619, DOI 10.1016/j.lfs.2012.02.010
   Nishino I, 2000, NATURE, V406, P906, DOI 10.1038/35022604
   NOHL H, 1978, EUR J BIOCHEM, V82, P563, DOI 10.1111/j.1432-1033.1978.tb12051.x
   Nojiri H, 2006, J BIOL CHEM, V281, P33789, DOI 10.1074/jbc.M602118200
   ODIET JA, 1995, MECH AGEING DEV, V79, P127, DOI 10.1016/0047-6374(94)01552-W
   Oellerich MF, 2012, CIRC RES, V110, P1238, DOI 10.1161/CIRCRESAHA.111.246488
   Oka T, 2012, NATURE, V485, P251, DOI 10.1038/nature10992
   Okada K, 2004, CIRCULATION, V110, P705, DOI 10.1161/01.CIR.0000137836.95625.D4
   ORGEL LE, 1963, P NATL ACAD SCI USA, V49, P517, DOI 10.1073/pnas.49.4.517
   Orlandi A, 2004, CARDIOVASC RES, V64, P544, DOI 10.1016/j.cardiores.2004.07.024
   Padrao AI, 2012, EUR J APPL PHYSIOL, V112, P1467, DOI 10.1007/s00421-011-2100-3
   PARADIES G, 1993, ARCH GERONTOL GERIAT, V16, P263, DOI 10.1016/0167-4943(93)90037-I
   PARADIES G, 1990, BIOCHIM BIOPHYS ACTA, V1016, P207, DOI 10.1016/0005-2728(90)90060-H
   PARADIES G, 1992, INT J BIOCHEM, V24, P783, DOI 10.1016/0020-711X(92)90012-P
   Paradies G, 2009, CELL CALCIUM, V45, P643, DOI 10.1016/j.ceca.2009.03.012
   Petrosillo G, 2010, J PINEAL RES, V48, P340, DOI 10.1111/j.1600-079X.2010.00758.x
   Picard M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043003
   Pollack M, 2002, ANN NY ACAD SCI, V959, P93, DOI 10.1111/j.1749-6632.2002.tb02086.x
   Powell SR, 2006, AM J PHYSIOL-HEART C, V291, pH1, DOI 10.1152/ajpheart.00062.2006
   Pretorius L, 2009, AM J PATHOL, V175, P998, DOI 10.2353/ajpath.2009.090126
   Pushpalatha K, 2007, ACTA BIOL HUNG, V58, P173, DOI 10.1556/ABiol.58.2007.2.4
   Qin FZ, 2010, CIRC-HEART FAIL, V3, P306, DOI 10.1161/CIRCHEARTFAILURE.109.864785
   Rask-Madsen C, 2012, ARTERIOSCL THROM VAS, V32, P2052, DOI 10.1161/ATVBAHA.111.241919
   Rask-Madsen C, 2010, CELL METAB, V11, P379, DOI 10.1016/j.cmet.2010.03.013
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Reiss K, 1996, P NATL ACAD SCI USA, V93, P8630, DOI 10.1073/pnas.93.16.8630
   Ren J, 2007, MECH AGEING DEV, V128, P276, DOI 10.1016/j.mad.2006.12.007
   Riva A, 2006, MECH AGEING DEV, V127, P917, DOI 10.1016/j.mad.2006.09.002
   Rivard A, 2000, J BIOL CHEM, V275, P29643, DOI 10.1074/jbc.M001029200
   Rivard A, 1999, CIRCULATION, V99, P111, DOI 10.1161/01.CIR.99.1.111
   Roger VL, 2012, CIRCULATION, V125, P188, DOI 10.1161/CIR.0b013e3182456d46
   Ron D, 2007, NAT REV MOL CELL BIO, V8, P519, DOI 10.1038/nrm2199
   Rueckschloss U, 2010, EXP GERONTOL, V45, P788, DOI 10.1016/j.exger.2010.05.002
   SACHS HG, 1977, AM J ANAT, V150, P63, DOI 10.1002/aja.1001500105
   Sahin E, 2011, NATURE, V470, P359, DOI 10.1038/nature09787
   Saltiel AR, 2001, NATURE, V414, P799, DOI 10.1038/414799a
   SAURA J, 1994, NEUROBIOL AGING, V15, P399, DOI 10.1016/0197-4580(94)90071-X
   Sawada T, 2010, J MOL CELL CARDIOL, V48, P1280, DOI 10.1016/j.yjmcc.2010.02.004
   SCHWARTZ SM, 1977, CIRC RES, V41, P248, DOI 10.1161/01.RES.41.2.248
   Sena S, 2009, J MOL CELL CARDIOL, V46, P910, DOI 10.1016/j.yjmcc.2009.02.014
   Sengupta A, 2009, J BIOL CHEM, V284, P28319, DOI 10.1074/jbc.M109.024406
   Serviddio G, 2007, REDOX REP, V12, P91, DOI 10.1179/135100007X162112
   Shimomura H, 2001, JPN CIRC J, V65, P965, DOI 10.1253/jcj.65.965
   Shirwany NA, 2010, ACTA PHARMACOL SIN, V31, P1267, DOI 10.1038/aps.2010.123
   SOHAL RS, 1970, EXP GERONTOL, V5, P213, DOI 10.1016/0531-5565(70)90040-9
   Strait JB, 2012, HEART FAIL CLIN, V8, P143, DOI 10.1016/j.hfc.2011.08.011
   Symons JD, 2009, CIRC RES, V104, P1085, DOI 10.1161/CIRCRESAHA.108.189316
   Szibor M, 2003, BASIC RES CARDIOL, V98, P210, DOI 10.1007/s00395-003-0421-z
   TAKASAWA M, 1993, EXP GERONTOL, V28, P269, DOI 10.1016/0531-5565(93)90034-B
   Tanaka Y, 2000, NATURE, V406, P902, DOI 10.1038/35022595
   Taneike M, 2010, AUTOPHAGY, V6, P600, DOI 10.4161/auto.6.5.11947
   Tatarková Z, 2011, PHYSIOL RES, V60, P281, DOI 10.33549/physiolres.932019
   Terman A, 2007, J PATHOL, V211, P134, DOI 10.1002/path.2094
   Terman A, 1998, MECH AGEING DEV, V100, P145, DOI 10.1016/S0047-6374(97)00129-2
   Terman A, 2004, ANN NY ACAD SCI, V1019, P70, DOI 10.1196/annals.1297.015
   Terman A, 2010, ANTIOXID REDOX SIGN, V12, P503, DOI 10.1089/ars.2009.2598
   Torella D, 2004, CIRC RES, V94, P514, DOI 10.1161/01.RES.0000117306.10142.50
   Trifunovic A, 2005, P NATL ACAD SCI USA, V102, P17993, DOI 10.1073/pnas.0508886102
   Trifunovic A, 2004, NATURE, V429, P417, DOI 10.1038/nature02517
   Ungvari Z, 2012, J GERONTOL A-BIOL, V67, P599, DOI 10.1093/gerona/gls072
   Vasan RS, 2003, ANN INTERN MED, V139, P642, DOI 10.7326/0003-4819-139-8-200310210-00007
   Vicent D, 2003, J CLIN INVEST, V111, P1373, DOI 10.1172/JCI200315211
   Villeneuve C, 2012, ANTIOXID REDOX SIGNA
   Vinciguerra M, 2010, AGING-US, V2, P43
   VIRMANI R, 1991, AM J PATHOL, V139, P1119
   Voziyan PA, 2002, ARCH BIOCHEM BIOPHYS, V397, P293, DOI 10.1006/abbi.2001.2620
   Wagner M, 2001, EXP GERONTOL, V36, P1327, DOI 10.1016/S0531-5565(01)00105-X
   Wallin R, 2001, MED RES REV, V21, P274, DOI 10.1002/med.1010
   Wang JC, 2012, CIRC RES, V111, P245, DOI 10.1161/CIRCRESAHA.111.261388
   Wang MY, 2010, CURR HYPERTENS REV, V6, P266, DOI 10.2174/157340210793611668
   Wang MY, 2010, J MOL CELL CARDIOL, V48, P765, DOI 10.1016/j.yjmcc.2010.01.006
   Wenzel P, 2008, CARDIOVASC RES, V80, P280, DOI 10.1093/cvr/cvn182
   Wessells RJ, 2004, NAT GENET, V36, P1275, DOI 10.1038/ng1476
   Wilson Peter W F, 2002, Am J Geriatr Cardiol, V11, P119
   Wilson PW, 2002, AM J GERIATR CARDIOL, V11, P125
   Wohlgemuth SE, 2007, REJUV RES, V10, P281, DOI 10.1089/rej.2006.0535
   Wu S, 2007, CLIN EXP PHARMACOL P, V34, P81, DOI 10.1111/j.1440-1681.2007.04540.x
   Yang YM, 2009, AM J PHYSIOL-HEART C, V297, pH1829, DOI 10.1152/ajpheart.00230.2009
   Yaniv Y, 2010, ANN NY ACAD SCI, V1188, P133, DOI 10.1111/j.1749-6632.2009.05093.x
   Zhou RH, 2012, ARTERIOSCL THROM VAS, V32, P745, DOI 10.1161/ATVBAHA.111.243121
   Zhou S, 2011, CIRC RES, V109, P639, DOI 10.1161/CIRCRESAHA.111.243592
   Zhu HX, 2007, J CLIN INVEST, V117, P1782, DOI 10.1172/JCI27523
NR 191
TC 28
Z9 30
U1 0
U2 11
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD OCT
PY 2013
VL 19
IS 32
BP 5684
EP 5694
DI 10.2174/1381612811319320004
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 207PK
UT WOS:000323614200004
PM 23448491
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Gendle, MH
   Spaeth, AM
   Dollard, SM
   Novaky, CA
AF Gendle, Mathew H.
   Spaeth, Andrea M.
   Dollard, Sarah M.
   Novaky, Cindy A.
TI Functional relationships between serum total cholesterol levels,
   executive control, and sustained attention
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Article
DE total cholesterol; cognition; stress; executive control; sustained
   attention
ID HIGH-FAT DIETS; PREFRONTAL CORTICAL FUNCTION; NUTRITION EXAMINATION
   SURVEY; 3RD NATIONAL-HEALTH; COGNITIVE FUNCTION; POSTPRANDIAL LIPEMIA;
   METABOLIC SYNDROME; LIPOPROTEIN RECEPTORS; NORMOLIPIDEMIC ADULTS;
   CARBOHYDRATE CONTENT
AB This study investigated the potential relationship between serum total cholesterol (TC) and two specific aspects of cognition a (executive control and sustained attention) in a non-elderly sample, after controlling for life stress and several sociodemographic and health variables. For each participant (n = 46), measurements of TC, physical healthe and life stress were obtained, and executive control and sustained attention were assessed using the Tower of London and the Digit Vigilance Test. The outcomes of these cognitive assessments were correlated with TC, and a co-variate-adjusted analysis was performed. After controlling for several co-variates, TC was found to be significantly negatively associated with components of executive control and sustained attention. Because these cognitive functions are crucial in the moment-to-moment regulation of behavior, elevated TC may have negative behavioral consequences in everyday life situations.
C1 [Gendle, Mathew H.; Spaeth, Andrea M.; Dollard, Sarah M.] Elon Univ, Dept Psychol, Elon, NC 27244 USA.
   [Novaky, Cindy A.] Elon Univ, Univ Wellness Coordinator, Elon, NC 27244 USA.
C3 Elon University; Elon University
RP Gendle, MH (corresponding author), Elon Univ, Dept Psychol, 2337 Campus Box, Elon, NC 27244 USA.
EM mgendle@elon.edu
CR Arnsten AFT, 1998, ARCH GEN PSYCHIAT, V55, P362, DOI 10.1001/archpsyc.55.4.362
   Arnsten AFT, 2000, PROG BRAIN RES, V126, P183
   Arnsten AFT, 1999, J AM ACAD CHILD PSY, V38, P220, DOI 10.1097/00004583-199902000-00024
   Astrup A, 2005, LANCET, V365, P4, DOI 10.1016/S0140-6736(04)17674-5
   Baker SC, 1996, NEUROPSYCHOLOGIA, V34, P515, DOI 10.1016/0028-3932(95)00133-6
   BENTON D, 1995, PSYCHOSOM MED, V57, P50, DOI 10.1097/00006842-199501000-00008
   BENTON D, 1997, LIPIDS HLTH BEHAV, P227
   Bergeron N, 1997, CURR OPIN LIPIDOL, V8, P43, DOI 10.1097/00041433-199702000-00010
   Birnbaum S, 1999, BIOL PSYCHIAT, V46, P1266, DOI 10.1016/S0006-3223(99)00138-9
   Björkhem I, 2004, ARTERIOSCL THROM VAS, V24, P806, DOI 10.1161/01.ATV.0000120374.59826.1b
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   Björntorp P, 2000, BRIT J NUTR, V83, pS49, DOI 10.1017/S0007114500000957
   Briefel RR, 2004, ANNU REV NUTR, V24, P401, DOI 10.1146/annurev.nutr.23.011702.073349
   Canfield RL, 2004, DEV NEUROPSYCHOL, V26, P513, DOI 10.1207/s15326942dn2601_8
   *CHOL CORP, 2003, ACC REPR REPR RAP FI
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   Constantinidis C, 2002, NAT NEUROSCI, V5, P175, DOI 10.1038/nn799
   Cournot M, 2006, NEUROLOGY, V67, P1208, DOI 10.1212/01.wnl.0000238082.13860.50
   Culbertson W. C., 2005, TOWER LONDON DREXEL
   Culbertson WC, 1998, ARCH CLIN NEUROPSYCH, V13, P285, DOI 10.1016/S0887-6177(97)00033-4
   Dehouck B, 1997, J CELL BIOL, V138, P877, DOI 10.1083/jcb.138.4.877
   Dietschy JM, 2001, CURR OPIN LIPIDOL, V12, P105, DOI 10.1097/00041433-200104000-00003
   DUBOIS C, 1994, AM J CLIN NUTR, V60, P374, DOI 10.1093/ajcn/60.3.374
   Dubois C, 1996, AM J CLIN NUTR, V64, P47, DOI 10.1093/ajcn/64.1.47
   DUBOIS C, 1994, J LIPID RES, V35, P1993
   Dubois C, 1998, AM J CLIN NUTR, V67, P31, DOI 10.1093/ajcn/67.1.31
   Dye L, 2000, NUTRITION, V16, P1021, DOI 10.1016/S0899-9007(00)00450-0
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Elias MF, 2003, INT J OBESITY, V27, P260, DOI 10.1038/sj.ijo.802225
   ELINS PK, 2005, PSYCHOSOM MED, V67, P24
   Fagan AM, 2000, ANN NEUROL, V48, P201, DOI 10.1002/1531-8249(200008)48:2<201::AID-ANA10>3.0.CO;2-X
   Fassbender K, 2002, NEUROLOGY, V59, P1257, DOI 10.1212/WNL.59.8.1257
   Flordellis CS, 2005, TRENDS ENDOCRIN MET, V16, P254, DOI 10.1016/j.tem.2005.06.001
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Forouhi NG, 2006, ATHEROSCLEROSIS SUPP, V7, P11, DOI 10.1016/j.atherosclerosissup.2006.01.003
   Fuster JM, 2000, NATURE, V405, P347, DOI 10.1038/35012613
   Fuster JM, 2000, EXP BRAIN RES, V133, P66, DOI 10.1007/s002210000401
   FUSTER JM, 1997, PREFRONTAL CORTEX
   GOEL V, 1995, NEUROPSYCHOLOGIA, V33, P623, DOI 10.1016/0028-3932(95)90866-P
   Granon S, 1998, Q J EXP PSYCHOL-B, V51, P219
   Greenwood CE, 1996, BEHAV NEUROSCI, V110, P451, DOI 10.1037/0735-7044.110.3.451
   GREENWOOD CE, 1990, BEHAV NEURAL BIOL, V53, P74, DOI 10.1016/0163-1047(90)90831-P
   Henderson VW, 2003, J NEUROL NEUROSUR PS, V74, P1530, DOI 10.1136/jnnp.74.11.1530
   Herz J, 2002, ANNU REV BIOCHEM, V71, P405, DOI 10.1146/annurev.biochem.71.110601.135342
   ISSA DF, 1996, ARQ BRAS CARDIOL, V66, P339
   KAPLAN JJ, 1999, LIPIDS HLTH BEHAV, P139
   KAPLAN JR, 1991, PSYCHOSOM MED, V53, P634, DOI 10.1097/00006842-199111000-00005
   KAPLAN JR, 1994, PSYCHOSOM MED, V56, P479, DOI 10.1097/00006842-199411000-00001
   Kaplan RJ, 1998, NEUROCHEM RES, V23, P615, DOI 10.1023/A:1022478503367
   Kelland DZ, 1996, ARCH CLIN NEUROPSYCH, V11, P339, DOI 10.1016/0887-6177(95)00032-1
   KESSLER AR, 1986, LIFE SCI, V38, P1185, DOI 10.1016/0024-3205(86)90173-6
   KESSLER AR, 1985, BIOCHEM PHARMACOL, V34, P1120, DOI 10.1016/0006-2952(85)90620-3
   Kimberg DY, 1997, CURR DIR PSYCHOL SCI, V6, P185, DOI 10.1111/1467-8721.ep10772959
   Kuller LH, 2004, CURR OPIN LIPIDOL, V15, P109, DOI 10.1097/00041433-200404000-00003
   Lairon D, 1996, REPROD NUTR DEV, V36, P345, DOI 10.1051/rnd:19960401
   Lewis, 1995, DIGIT VIGILANCE TEST
   LLOYD HM, 1994, PHYSIOL BEHAV, V56, P51, DOI 10.1016/0031-9384(94)90260-7
   Lloyd HM, 1996, APPETITE, V27, P151, DOI 10.1006/appe.1996.0042
   MASON RP, 1991, J MOL CELL CARDIOL, V23, P1339, DOI 10.1016/0022-2828(91)90091-Y
   Michikawa M, 2003, J NEUROSCI RES, V72, P141, DOI 10.1002/jnr.10585
   MICKEY RM, 1989, AM J EPIDEMIOL, V129, P125, DOI 10.1093/oxfordjournals.aje.a115101
   Miller EK, 2001, ANNU REV NEUROSCI, V24, P167, DOI 10.1146/annurev.neuro.24.1.167
   Molteni R, 2002, NEUROSCIENCE, V112, P803, DOI 10.1016/S0306-4522(02)00123-9
   Moos R.H., 1994, LIFE STRESSORS SOCIA
   MOOS RH, 1988, SOC SCI MED, V27, P999, DOI 10.1016/0277-9536(88)90291-2
   Muldoon MF, 1997, PSYCHOSOM MED, V59, P382, DOI 10.1097/00006842-199707000-00008
   Muldoon MF, 2000, AM J MED, V108, P538, DOI 10.1016/S0002-9343(00)00353-3
   Oliver G, 2000, PSYCHOSOM MED, V62, P853, DOI 10.1097/00006842-200011000-00016
   Ose Leiv, 1995, Tidsskrift for den Norske Laegeforening, V115, P3487
   Panz V R, 2005, Cardiovasc J S Afr, V16, P112
   Pavlik VN, 2005, NEUROEPIDEMIOLOGY, V24, P42, DOI 10.1159/000081049
   POSNER MI, 1990, ANNU REV NEUROSCI, V13, P25, DOI 10.1146/annurev.ne.13.030190.000325
   Pozzi F, 2003, PSYCHIAT RES, V120, P239, DOI 10.1016/S0165-1781(03)00192-6
   Prentice A M, 2003, Obes Rev, V4, P187, DOI 10.1046/j.1467-789X.2003.00117.x
   Puttonen S, 2003, NEUROPSYCHOBIOLOGY, V48, P35, DOI 10.1159/000071827
   Qiu SF, 2006, NEUROBIOL LEARN MEM, V85, P16, DOI 10.1016/j.nlm.2005.08.009
   REITAN RM, 1963, J GERONTOL, V18, P350, DOI 10.1093/geronj/18.4.350
   Rogers PJ, 2001, P NUTR SOC, V60, P135, DOI 10.1079/PNS200061
   Rowe JB, 2001, NEUROPSYCHOLOGIA, V39, P315, DOI 10.1016/S0028-3932(00)00109-3
   Rubin DA, 2003, INT J SPORT NUTR EXE, V13, P358, DOI 10.1123/ijsnem.13.3.358
   Santee J, 2002, AM J HEALTH-SYST PH, V59, P1774, DOI 10.1093/ajhp/59.18.1774
   Sapolsky RM, 1996, SCIENCE, V273, P749, DOI 10.1126/science.273.5276.749
   Sarter M, 2001, BRAIN RES REV, V35, P146, DOI 10.1016/S0165-0173(01)00044-3
   SHALLICE T, 1982, PHILOS T R SOC B, V298, P199, DOI 10.1098/rstb.1982.0082
   Shemesh T, 2006, CLIN CHIM ACTA, V367, P69, DOI 10.1016/j.cca.2005.11.014
   Stein JH, 2002, CLIN CHEM, V48, P284
   Vance JE, 2005, SEMIN CELL DEV BIOL, V16, P193, DOI 10.1016/j.semcdb.2005.01.005
   Volles DF, 1998, PHARMACOTHERAPY, V18, P184
   Wang Minghan, 2005, Nutr Metab (Lond), V2, P3, DOI 10.1186/1743-7075-2-3
   Wardle J, 2000, AM J MED, V108, P547, DOI 10.1016/S0002-9343(00)00330-2
   WINOCUR G, 1993, PSYCHOBIOLOGY, V21, P286
   Winocur G, 1999, BEHAV BRAIN RES, V101, P153, DOI 10.1016/S0166-4328(98)00147-8
   Wu A, 2003, NEUROSCIENCE, V119, P365, DOI 10.1016/S0306-4522(03)00154-4
   Zhang J, 2004, AM J CLIN NUTR, V80, P291, DOI 10.1093/ajcn/80.2.291
NR 94
TC 7
Z9 9
U1 0
U2 8
PU MANEY PUBLISHING
PI LEEDS
PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND
SN 1028-415X
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PD APR
PY 2008
VL 11
IS 2
BP 84
EP 94
DI 10.1179/147683008X301469
PG 11
WC Neurosciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Nutrition & Dietetics
GA 317DH
UT WOS:000256999300006
PM 18510808
DA 2025-06-11
ER

PT J
AU Puttabyatappa, M
   Martin, JD
   Andriessen, V
   Stevenson, M
   Zeng, LX
   Pennathur, S
   Padmanabhan, V
AF Puttabyatappa, Muraly
   Martin, Jacob D.
   Andriessen, Victoria
   Stevenson, Micaela
   Zeng, Lixia
   Pennathur, Subramaniam
   Padmanabhan, Vasantha
TI Developmental programming: Changes in mediators of insulin sensitivity
   in prenatal bisphenol A-treated female sheep
SO REPRODUCTIVE TOXICOLOGY
LA English
DT Article
DE Endocrine disruptor; Bisphenol A; Insulin resistance; Oxidative stress;
   Inflammation; Lipotoxicity
ID ENDOCRINE-DISRUPTING CHEMICALS; UMBILICAL-CORD SERUM; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; BPA EXPOSURE; TESTOSTERONE EXCESS; METABOLIC SYNDROME;
   SEX STEROIDS; LH SURGE; RESISTANCE
AB Developmental exposure to endocrine disruptor bisphenol A (BPA) is associated with metabolic defects during adulthood. In sheep, prenatal BPA treatment causes insulin resistance (IR) and adipocyte hypertrophy in the female offspring. To determine if changes in insulin sensitivity mediators (increase in inflammation, oxidative stress, and lipotoxicity and/or decrease in adiponectin) and the intracrine steroidal milieu contributes to these metabolic perturbations, metabolic tissues collected from 21-month-old female offspring born to mothers treated with 0, 0.05, 0.5, or 5 mg/kg/day of BPA were studied. Findings showed prenatal BPA in non-monotonic manner (1) increased oxidative stress; (2) induced lipotoxicity in liver and muscle; and (3) increased aromatase and estrogen receptor expression in visceral adipose tissues. These changes are generally associated with the development of peripheral and tissue level IR and may explain the IR status and adipocyte hypertrophy observed in prenatal BPA-treated female sheep.
C1 [Puttabyatappa, Muraly; Martin, Jacob D.; Andriessen, Victoria; Stevenson, Micaela; Padmanabhan, Vasantha] Univ Michigan, Dept Pediat, MSRB1 7510,1500 W Med Ctr Dr, Ann Arbor, MI 48109 USA.
   [Zeng, Lixia; Pennathur, Subramaniam] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA.
   [Pennathur, Subramaniam; Padmanabhan, Vasantha] Univ Michigan, Dept Mol Physiol, Ann Arbor, MI 48109 USA.
   [Pennathur, Subramaniam; Padmanabhan, Vasantha] Univ Michigan, Dept Integrat Physiol, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; University of Michigan System;
   University of Michigan; University of Michigan System; University of
   Michigan
RP Padmanabhan, V (corresponding author), Univ Michigan, Dept Pediat, MSRB1 7510,1500 W Med Ctr Dr, Ann Arbor, MI 48109 USA.
EM vasantha@umich.edu
RI Puttabyatappa, Muraly/K-2598-2015; Pennathur, Subramaniam/O-7032-2017;
   Stevenson, Micaela/JPA-0105-2023; Padmanabhan, Vasantha/C-8558-2017
OI Pennathur, Subramaniam/0000-0003-3628-6883
FU National Institute of Environmental Health Sciences [R01-ES-016541];
   Ruth L. Kirschstein Institutional Training Grant from the National
   Institutes of Health/National Institute for Environmental Health
   Sciences [T32 ES007062]; National Institute of Diabetes and Digestive
   and Kidney Diseases [P30DK020572] Funding Source: NIH RePORTER; National
   Institute of Environmental Health Sciences [P30ES017885, T32ES007062]
   Funding Source: NIH RePORTER
FX This work was supported by National Institute of Environmental Health
   Sciences Grant R01-ES-016541 (VP) and Ruth L. Kirschstein Institutional
   Training Grant from the National Institutes of Health/National Institute
   for Environmental Health SciencesT32 ES007062 to MP
CR Ahmed RG, 2016, FOOD CHEM TOXICOL, V95, P168, DOI 10.1016/j.fct.2016.06.017
   Alonso-Magdalena P, 2010, HORM-INT J ENDOCRINO, V9, P118, DOI 10.1007/BF03401277
   [Anonymous], 2014, 4 CDCP
   Barker DJP, 2005, HORM RES, V64, P2, DOI 10.1159/000089311
   Bashan N, 2009, PHYSIOL REV, V89, P27, DOI 10.1152/physrev.00014.2008
   BASSETT JM, 1974, AUST J BIOL SCI, V27, P167, DOI 10.1071/BI9740167
   Biasiotto G, 2016, TOXICOL APPL PHARM, V297, P32, DOI 10.1016/j.taap.2016.02.023
   Biddinger SB, 2006, ANNU REV PHYSIOL, V68, P123, DOI 10.1146/annurev.physiol.68.040104.124723
   BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911
   Calafat AM, 2005, ENVIRON HEALTH PERSP, V113, P391, DOI 10.1289/ehp.7534
   Calafat AM, 2008, ENVIRON HEALTH PERSP, V116, P39, DOI 10.1289/ehp.10753
   Cardoso RC, 2016, ENDOCRINOLOGY, V157, P522, DOI 10.1210/en.2015-1565
   Caselli C, 2014, MOL GENET METAB, V113, P155, DOI 10.1016/j.ymgme.2014.09.003
   Clarke IJ, 2008, FRONT HORM RES, V36, P107, DOI 10.1159/000115359
   COHEN J, 1992, PSYCHOL BULL, V112, P155, DOI 10.1037/0033-2909.112.1.155
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   Evans JL, 2005, ANTIOXID REDOX SIGN, V7, P1040, DOI 10.1089/ars.2005.7.1040
   Faulk C, 2015, ENVIRON EPIGENETICS, V1, DOI 10.1093/eep/dvv006
   Foulds C, 2017, NAT REV ENDOCRINOL, V13, P445, DOI 10.1038/nrendo.2017.42
   Fu YC, 2014, PROG MOL BIOL TRANSL, V121, P293, DOI 10.1016/B978-0-12-800101-1.00009-0
   Fuller-Jackson JP, 2018, J ENDOCRINOL, V237, pR99, DOI 10.1530/JOE-18-0090
   Gerona RR, 2013, ENVIRON SCI TECHNOL, V47, P12477, DOI 10.1021/es402764d
   Gonzalez-Bulnes A, 2017, CURR PHARM BIOTECHNO, V18, P541, DOI 10.2174/1389201018666170811150920
   Guignard D, 2017, CHEMOSPHERE, V182, P458, DOI 10.1016/j.chemosphere.2017.05.028
   Gustafson B, 2015, TRENDS ENDOCRIN MET, V26, P193, DOI 10.1016/j.tem.2015.01.006
   JANES AN, 1985, BRIT J NUTR, V54, P459, DOI 10.1079/BJN19850131
   Janesick AS, 2016, AM J OBSTET GYNECOL, V214, P559, DOI 10.1016/j.ajog.2016.01.182
   Kadowaki T, 2005, ENDOCR REV, V26, P439, DOI 10.1210/er.2005-0005
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Klöting N, 2014, REV ENDOCR METAB DIS, V15, P277, DOI 10.1007/s11154-014-9301-0
   Lagarde F, 2015, ENVIRON HEALTH-GLOB, V14, DOI 10.1186/1476-069X-14-13
   Landrigan PJ, 2016, ANN GLOB HEALTH, V82, P10, DOI 10.1016/j.aogh.2016.01.005
   Lassailly G, 2016, GASTROENTEROLOGY, V150, P1835, DOI 10.1053/j.gastro.2016.03.004
   Lee BE, 2014, INT J HYG ENVIR HEAL, V217, P328, DOI 10.1016/j.ijheh.2013.07.005
   Lee BC, 2014, BBA-MOL BASIS DIS, V1842, P446, DOI 10.1016/j.bbadis.2013.05.017
   Lee HJ, 2003, TOXICOL SCI, V75, P40, DOI 10.1093/toxsci/kfg150
   Lee J, 2018, SCI TOTAL ENVIRON, V626, P1494, DOI 10.1016/j.scitotenv.2017.10.042
   Lejeune M, 2008, J ANAT, V212, P868, DOI 10.1111/j.1469-7580.2008.00910.x
   Li JH, 2015, STEROIDS, V103, P89, DOI 10.1016/j.steroids.2015.03.016
   Liu WS, 2016, CELL MOL LIFE SCI, V73, P1969, DOI 10.1007/s00018-016-2161-x
   Lonardo A, 2017, WORLD J GASTROENTERO, V23, P6571, DOI 10.3748/wjg.v23.i36.6571
   Lu CX, 2016, BIOL REPROD, V94, DOI 10.1095/biolreprod.115.136283
   Ma Y, 2013, DIABETOLOGIA, V56, P2059, DOI 10.1007/s00125-013-2944-7
   Manikkam M, 2004, ENDOCRINOLOGY, V145, P790, DOI 10.1210/en.2003-0478
   McMillen IC, 2005, J PHYSIOL-LONDON, V565, P9, DOI 10.1113/jphysiol.2004.081992
   Mehlem A, 2013, NAT PROTOC, V8, P1149, DOI 10.1038/nprot.2013.055
   Mielenz M, 2013, DOMEST ANIM ENDOCRIN, V44, P121, DOI 10.1016/j.domaniend.2012.10.004
   Miyawaki J, 2007, J ATHEROSCLER THROMB, V14, P245, DOI 10.5551/jat.E486
   Moon MK, 2015, J ENDOCRINOL, V226, P35, DOI 10.1530/JOE-14-0714
   Mullur R, 2014, PHYSIOL REV, V94, P355, DOI 10.1152/physrev.00030.2013
   Nakagawa S, 2007, BIOL REV, V82, P591, DOI 10.1111/j.1469-185X.2007.00027.x
   Newbold RR, 2010, HORM-INT J ENDOCRINO, V9, P206, DOI 10.14310/horm.2002.1271
   Newell-Fugate AE, 2017, REPRODUCTION, V153, pR133, DOI 10.1530/REP-16-0417
   Ortega HH, 2009, REPRODUCTION, V137, P865, DOI 10.1530/REP-08-0491
   Padmanabhan V, 2014, J ANIM SCI, V92, P3199, DOI 10.2527/jas.2014-7637
   Padmanabhan V, 2015, ENDOCRINOLOGY, V156, P2678, DOI 10.1210/en.2015-1235
   Perry RJ, 2014, NATURE, V510, P84, DOI 10.1038/nature13478
   Pu Y, 2017, ENDOCRINOLOGY, V158, P3844, DOI 10.1210/en.2017-00615
   Puttabyatappa M., 2017, ENDOCRINOLOGY
   Puttabyatappa M., 2017, REPROD SCI
   Puttabyatappa M, 2017, ADV EXP MED BIOL, V1043, P575, DOI 10.1007/978-3-319-70178-3_25
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   Saal FSV, 2012, MOL CELL ENDOCRINOL, V354, P74, DOI 10.1016/j.mce.2012.01.001
   SANO H, 1990, J ANIM SCI, V68, P3736
   Shulman GI, 2014, NEW ENGL J MED, V371, P1131, DOI 10.1056/NEJMra1011035
   Somm E, 2009, ENVIRON HEALTH PERSP, V117, P1549, DOI 10.1289/ehp.11342
   Song SZ, 2014, INT J ENV RES PUB HE, V11, P3728, DOI 10.3390/ijerph110403728
   Sternbauer K, 2002, ACTA VET SCAND, V43, P107, DOI 10.1186/1751-0147-43-107
   Strakovsky RS, 2015, TOXICOL APPL PHARM, V284, P101, DOI 10.1016/j.taap.2015.02.021
   Styskal J, 2012, FREE RADICAL BIO MED, V52, P46, DOI 10.1016/j.freeradbiomed.2011.10.441
   Tchernof A, 1998, CORONARY ARTERY DIS, V9, P503, DOI 10.1097/00019501-199809080-00006
   Teppala S, 2012, INT J ENDOCRINOL, V2012, DOI 10.1155/2012/598180
   Turgeon JL, 2006, ENDOCR REV, V27, P575, DOI 10.1210/er.2005-0020
   van Esterik JCJ, 2014, TOXICOLOGY, V321, P40, DOI 10.1016/j.tox.2014.04.001
   Vandenberg LN, 2014, DOSE-RESPONSE, V12, P259, DOI 10.2203/dose-response.13-020.Vandenberg
   Veiga-Lopez A, 2014, TOXICOL APPL PHARM, V279, P119, DOI 10.1016/j.taap.2014.05.016
   Veiga-Lopez A, 2013, ENDOCRINOLOGY, V154, P1731, DOI 10.1210/en.2012-2145
   Veiga-Lopez A, 2016, AM J PHYSIOL-ENDOC M, V310, pE238, DOI 10.1152/ajpendo.00425.2015
   Veiga-Lopez A, 2015, J CLIN ENDOCR METAB, V100, pE1394, DOI 10.1210/jc.2015-1724
   Veiga-Lopez A, 2015, ENDOCRINOLOGY, V156, P911, DOI 10.1210/en.2014-1863
   Veiga-Lopez A, 2013, ENDOCRINOLOGY, V154, P1873, DOI 10.1210/en.2012-2129
   Verdile G, 2015, MEDIAT INFLAMM, V2015, DOI 10.1155/2015/105828
   Viguié C, 2013, ENDOCRINOLOGY, V154, P521, DOI 10.1210/en.2012-1401
   Vivekanandan-Giri A, 2011, METHOD ENZYMOL, V491, P73, DOI 10.1016/B978-0-12-385928-0.00005-5
   Vogel Sarah A, 2009, Am J Public Health, V99 Suppl 3, pS559, DOI 10.2105/AJPH.2008.159228
   vom Saal FS, 2016, J ANIM SCI, V94, P2722, DOI 10.2527/jas.2015-0211
   vom Saal FS, 2007, REPROD TOXICOL, V24, P131, DOI 10.1016/j.reprotox.2007.07.005
   Wang TG, 2012, J CLIN ENDOCR METAB, V97, pE223, DOI 10.1210/jc.2011-1989
   Wei J, 2011, ENDOCRINOLOGY, V152, P3049, DOI 10.1210/en.2011-0045
   Withers DJ, 2000, ENDOCRINOLOGY, V141, P1917, DOI 10.1210/en.141.6.1917
   Zimmet PZ, 2006, OBESITY, V14, P1, DOI 10.1038/oby.2006.1
NR 91
TC 22
Z9 23
U1 0
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0890-6238
J9 REPROD TOXICOL
JI Reprod. Toxicol.
PD APR
PY 2019
VL 85
BP 110
EP 122
DI 10.1016/j.reprotox.2019.03.002
PG 13
WC Reproductive Biology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Reproductive Biology; Toxicology
GA HT5TH
UT WOS:000464625700015
PM 30853570
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Wu, WW
   Xu, H
   Wang, ZM
   Mao, Y
   Yuan, LS
   Luo, W
   Cui, ZQ
   Cui, TX
   Wang, XL
   Shen, YH
AF Wu, Weiwei
   Xu, Hao
   Wang, Zemin
   Mao, Yun
   Yuan, Liangshuai
   Luo, Wei
   Cui, Zhaoqiang
   Cui, Taixing
   Wang, Xing Li
   Shen, Ying H.
TI PINK1-Parkin-Mediated Mitophagy Protects Mitochondrial Integrity and
   Prevents Metabolic Stress-Induced Endothelial Injury
SO PLOS ONE
LA English
DT Article
ID MUTATIONS; DISEASE; PARKIN; REGULATORS; AUTOPHAGY; MEMBRANE
AB Mitochondrial injury and dysfunction, a significant feature in metabolic syndrome, triggers endothelial cell dysfunction and cell death. Increasing evidence suggests that mitophagy, a process of autophagic turnover of damaged mitochondria, maintains mitochondrial integrity. PINK1 (phosphatase and tensin homolog (PTEN)-induced putative kinase 1) and Parkin signaling is a key pathway in mitophagy control. In this study, we examined whether this pathway could protect mitochondria under metabolic stress. We found that palmitic acid (PA) induced significant mitophagy and activated PINK1 and Parkin in endothelial cells. Knocking down PINK1 or Parkin reduced mitophagy, leading to impaired clearance of damaged mitochondria and intracellular accumulation of mitochondrial fragments. Furthermore, PINK1 and Parkin prevented PA-induced mitochondrial dysfunction, ROS production and apoptosis. Finally, we show that PINK1 and Parkin were up-regulated in vascular wall of obese mice and diabetic mice. Our study demonstrates that PINK1-Parkin pathway is activated in response to metabolic stress. Through induction of mitophagy, this pathway protects mitochondrial integrity and prevents metabolic stress-induced endothelial injury.
C1 [Wu, Weiwei; Xu, Hao; Wang, Zemin; Mao, Yun; Yuan, Liangshuai; Luo, Wei; Cui, Zhaoqiang; Cui, Taixing; Wang, Xing Li] Shandong Univ, Res Ctr Cell Therapy, Key Lab Cardiovasc Remodeling & Funct Res, Qilu Hosp, Jinan 250012, Peoples R China.
   [Cui, Taixing] Univ S Carolina, Dept Cell Biol & Anat, Columbus, SC 29209 USA.
   [Wang, Xing Li; Shen, Ying H.] Baylor Coll Med, Div Cardiothorac Surg, Michael E DeBakey Dept Surg, Houston, TX 77030 USA.
   [Wang, Xing Li; Shen, Ying H.] Texas Heart Inst, Houston, TX 77025 USA.
C3 Shandong University; University of South Carolina System; University of
   South Carolina Columbia; Baylor College of Medicine; Texas Heart
   Institute
RP Wang, XL (corresponding author), Shandong Univ, Res Ctr Cell Therapy, Key Lab Cardiovasc Remodeling & Funct Res, Qilu Hosp, Jinan 250012, Peoples R China.
EM xingliwang@sdu.edu.cn; hyshen@bcm.edu
RI wang, xingli/MHR-1399-2025; Wu, Weiwei/AFY-8257-2022; shen,
   ying/HHS-5635-2022
OI Luo, Wei/0000-0001-9416-9592
FU Shandong University National Qianren Scholar Fund; National 973 Program
   Grant [2014CB542401]
FX This work was supported by the Shandong University National Qianren
   Scholar Fund (XLW) and by the National 973 Program Grant (2014CB542401).
   The funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
CR Beilina A, 2005, P NATL ACAD SCI USA, V102, P5703, DOI 10.1073/pnas.0500617102
   Chen YR, 2014, CIRC RES, V114, P524, DOI 10.1161/CIRCRESAHA.114.300559
   Davidson SM, 2007, CIRC RES, V100, P1128, DOI 10.1161/01.RES.0000261970.18328.1d
   Dorn G.W., 2014, CIRC RES
   Galluzzi L, 2012, NAT REV MOL CELL BIO, V13, P780, DOI 10.1038/nrm3479
   Geisler S, 2010, NAT CELL BIOL, V12, P119, DOI 10.1038/ncb2012
   Green DR, 2014, SCIENCE, V345, P1466, DOI 10.1126/science.1250256
   Green DR, 2011, SCIENCE, V333, P1109, DOI 10.1126/science.1201940
   HAYWOOD LJ, 1988, JAMA-J AM MED ASSOC, V259, P1328
   Kitada T, 1998, NATURE, V392, P605, DOI 10.1038/33416
   Kluge MA, 2013, CIRC RES, V112, P1171, DOI 10.1161/CIRCRESAHA.111.300233
   Kubli DA, 2012, CIRC RES, V111, P1208, DOI 10.1161/CIRCRESAHA.112.265819
   LI X, 2009, DIABETES
   Lupfer C, 2013, NAT IMMUNOL, V14, P480, DOI 10.1038/ni.2563
   Madamanchi NR, 2007, CIRC RES, V100, P460, DOI 10.1161/01.RES.0000258450.44413.96
   Nunnari J, 2012, CELL, V148, P1145, DOI 10.1016/j.cell.2012.02.035
   Rizzuto R, 2012, NAT REV MOL CELL BIO, V13, P566, DOI 10.1038/nrm3412
   Shen YH, 2013, CIRC RES, V112, P618, DOI 10.1161/CIRCRESAHA.112.300735
   Springer W, 2011, AUTOPHAGY, V7, P266, DOI 10.4161/auto.7.3.14348
   Tait SWG, 2010, NAT REV MOL CELL BIO, V11, P621, DOI 10.1038/nrm2952
   Valente EM, 2004, SCIENCE, V304, P1158, DOI 10.1126/science.1096284
   Vives-Bauza C, 2010, P NATL ACAD SCI USA, V107, P378, DOI 10.1073/pnas.0911187107
   Wang K, 2011, AUTOPHAGY, V7, P297, DOI 10.4161/auto.7.3.14502
   Yoshii SR, 2011, J BIOL CHEM, V286, P19630, DOI 10.1074/jbc.M110.209338
   Youle RJ, 2011, NAT REV MOL CELL BIO, V12, P9, DOI 10.1038/nrm3028
   Zhu JH, 2011, METHODS MOL BIOL, V793, P325, DOI 10.1007/978-1-61779-328-8_21
NR 26
TC 117
Z9 138
U1 0
U2 22
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 10
PY 2015
VL 10
IS 7
AR e0132499
DI 10.1371/journal.pone.0132499
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CN1FD
UT WOS:000358162300142
PM 26161534
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Turgut, O
   Tandogan, I
AF Turgut, Okan
   Tandogan, Izzet
TI Gamma-glutamyltransferase to Determine Cardiovascular Risk: Shifting the
   Paradigm Forward
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Review
DE Cardiovascular risk; Gamma-glutamyltranferase; Oxidative stress;
   Prognosis
ID MALE WORKERS 3M; METABOLIC SYNDROME; OXIDATIVE STRESS;
   MYOCARDIAL-INFARCTION; PROGNOSTIC VALUE; HEART-DISEASE; FATTY LIVER;
   HIPOP-OHP; ATHEROSCLEROSIS; ASSOCIATION
AB Gamma-glutamyltransferase (GGT), regarded as a marker of excessive alcohol consumption or liver disturbances, is an enzyme catalyzing the first step in the extracellular degradation of the antioxidant glutathione (GSH) and may take part in atherogenesis. The marked relationship between GGT and the atherosclerotic process has shifted attention to the issue of whether its serum levels can aid in the detection of individuals at high risk for incident cardiovascular events. It is likely that the process entails the oxidation of low-density lipoprotein through GSH/GGT-dependent iron reduction within the plaque. In this context, oxidative stress is a probable mediator. Recent insights into the pathophysiological background of GGT in the precipitation and progression of atherosclerosis appear to be supported by relevant epidemiological observations as a cardiovascular risk predictor. Further understanding is, nevertheless, warranted to ameliorate the prognostic stratification of patients through GGT.
C1 [Turgut, Okan; Tandogan, Izzet] Cumhuriyet Univ, Dept Cardiol, Fac Med, TR-58140 Sivas, Turkey.
C3 Cumhuriyet University
RP Turgut, O (corresponding author), Cumhuriyet Univ, Dept Cardiol, Fac Med, TR-58140 Sivas, Turkey.
EM okanturgut@lycos.com
RI Turgut, Okan/C-4396-2008
OI Turgut, Okan/0000-0002-6847-3029
CR Bolodeoku JA, 1997, PLATELETS, V8, P333
   Emdin M, 2005, CIRCULATION, V112, P2078, DOI 10.1161/CIRCULATIONAHA.105.571919
   Emdin M, 2001, EUR HEART J, V22, P1802, DOI 10.1053/euhj.2001.2807
   Emdin M, 2006, EUR HEART J, V27, P2145, DOI 10.1093/eurheartj/ehl151
   Emdin M, 2009, INT J CARDIOL, V136, P80, DOI 10.1016/j.ijcard.2008.04.030
   Franzini M, 2009, ATHEROSCLEROSIS, V202, P119, DOI 10.1016/j.atherosclerosis.2008.03.023
   Grundy SM, 2007, ARTERIOSCL THROM VAS, V27, P4, DOI 10.1161/01.ATV.0000253905.13219.4b
   GURDOL F, 1995, PLATELETS, V6, P200, DOI 10.3109/09537109509078455
   Hayakawa T, 2010, J ATHEROSCLER THROMB, V17, P64, DOI 10.5551/jat.1727
   Hozawa A, 2007, ATHEROSCLEROSIS, V194, P498, DOI 10.1016/j.atherosclerosis.2006.08.058
   Hozawa A, 2010, J ATHEROSCLER THROMB, V17, P195, DOI 10.5551/jat.3202
   Ishizaka N, 2010, J ATHEROSCLER THROMB, V17, P476, DOI 10.5551/jat.2717
   Kawamoto R, 2009, J ATHEROSCLER THROMB, V16, P355, DOI 10.5551/jat.No414
   Lee DH, 2005, ATHEROSCLEROSIS, V178, P327, DOI 10.1016/j.atherosclerosis.2004.08.027
   Lee DS, 2007, ARTERIOSCL THROM VAS, V27, P127, DOI 10.1161/01.ATV.0000251993.20372.40
   Mabile L, 2003, DIABETES CARE, V26, P1652, DOI 10.2337/diacare.26.5.1652
   Maruyama K, 2009, J ATHEROSCLER THROMB, V16, P714
   Mascitelli L, 2009, ARCH MED RES, V40, P640, DOI 10.1016/j.arcmed.2009.10.003
   Noda H, 2010, J ATHEROSCLER THROMB, V17, P452, DOI 10.5551/jat.3277
   Paolicchi A, 2006, ATHEROSCLEROSIS, V186, P80, DOI 10.1016/j.atherosclerosis.2005.07.012
   Pleiner J, 2003, J AM COLL CARDIOL, V42, P1656, DOI 10.1016/j.jacc.2003.06.002
   Ruttmann E, 2005, CIRCULATION, V112, P2130, DOI 10.1161/CIRCULATIONAHA.105.552547
   Schulze P Christian, 2005, Curr Atheroscler Rep, V7, P242, DOI 10.1007/s11883-005-0013-5
   Tamura U, 2010, J ATHEROSCLER THROMB, V17, P12, DOI 10.5551/jat.1800
   Tokgözoglu L, 2008, J ATHEROSCLER THROMB, V15, P286, DOI 10.5551/jat.E614
   Tsutsumi M, 2001, ALCOHOL CLIN EXP RES, V25, p75S, DOI 10.1097/00000374-200106001-00017
   Turgut O, 2006, MED HYPOTHESES, V67, P1060, DOI 10.1016/j.mehy.2006.04.010
   Turgut O, 2009, ARCH MED RES, V40, P318, DOI 10.1016/j.arcmed.2009.04.006
   Turgut O, 2009, ATHEROSCLEROSIS, V202, P348, DOI 10.1016/j.atherosclerosis.2008.05.019
   Villanova N, 2005, HEPATOLOGY, V42, P473, DOI 10.1002/hep.20781
   WANNAMETHEE G, 1995, AM J EPIDEMIOL, V142, P699, DOI 10.1093/oxfordjournals.aje.a117699
   Yamada J, 2006, ATHEROSCLEROSIS, V189, P198, DOI 10.1016/j.atherosclerosis.2005.11.036
NR 32
TC 54
Z9 58
U1 1
U2 6
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PY 2011
VL 18
IS 3
BP 177
EP 181
DI 10.5551/jat.6189
PG 5
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 750FJ
UT WOS:000289530600001
PM 21041983
OA hybrid
DA 2025-06-11
ER

PT J
AU Sekiya, M
   Hiraishi, A
   Touyama, M
   Sakamoto, K
AF Sekiya, Mika
   Hiraishi, Ako
   Touyama, Maiko
   Sakamoto, Kazuichi
TI Oxidative stress induced lipid accumulation via SREBP1c activation in
   HepG2 cells
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Fatty acid biosynthesis; Adipogenesis; ROS; Transcription factor
ID TRANSCRIPTION FACTOR; BINDING; INSULIN; PROTEIN; CLEAVAGE; OBESITY;
   KINASE
AB SREBP1c (sterol regulatory element-binding protein 1c) is a metabolic-syndrome-associated transcription factor that controls fatty acid biosynthesis under glucose/insulin stimulation. Oxidative stress increases lipid accumulation, which promotes the generation of reactive oxygen species (ROS). However, we know little about the role of oxidative stress in fatty acid biosynthesis. To clarify the action of oxidative stress in lipid accumulation via SREBP1c, we examined SREBP1c activity in H2O2-treated mammalian cells. We introduced a luciferase reporter plasmid carrying the SREBP1c-binding site into HepG2 or COS-7 cells. With increasing H2O2 dose, SREBP1c transcriptional activity increased in HepG2 cells but declined in COS-7 cells. RT-PCR analysis revealed that mRNA expression of SREBP1c gene or of SREBP1c-regulated genes rose H2O2 dose-dependently in HepG2 cells but dropped in COS-7 cells. Lipid accumulation and levels of the nuclear form of SREBP1c increased in H2O2-stimulated HepG2 cells. ROS may stimulate lipid accumulation in HepG2 cells via SREBP1c activation. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Sekiya, Mika; Hiraishi, Ako; Touyama, Maiko; Sakamoto, Kazuichi] Univ Tsukuba, Grad Sch Life & Environm Sci, Tsukuba, Ibaraki 3058572, Japan.
C3 University of Tsukuba
RP Sakamoto, K (corresponding author), Univ Tsukuba, Grad Sch Life & Environm Sci, 1-1-1 Tennoudai, Tsukuba, Ibaraki 3058572, Japan.
EM sakamoto@biol.tsukuba.ac.jp
FU Ministry of Education, Science, Sports, and Culture of Japan
FX We thank Dr. Hitoshi Shimano (University of Tsukuba) for providing
   plasmid of pGL2-basic SREBP1 c (-2.6 kb) promoter Luc. This work was
   supported in part by Grants-in-Aid for Scientific Research from the
   Ministry of Education, Science, Sports, and Culture of Japan.
CR Abbatecola AM, 2004, J AM GERIATR SOC, V52, P399, DOI 10.1111/j.1532-5415.2004.52112.x
   Azzout-Marniche D, 2000, BIOCHEM J, V350, P389, DOI 10.1042/0264-6021:3500389
   BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911
   Christenson LK, 2001, ENDOCRINOLOGY, V142, P28, DOI 10.1210/endo.142.1.7867
   Colgan SM, 2007, INT J BIOCHEM CELL B, V39, P1843, DOI 10.1016/j.biocel.2007.05.002
   DELPHINE E, 2004, BIOCHIMIE, V86, P839
   Duncan EA, 1998, J BIOL CHEM, V273, P17801, DOI 10.1074/jbc.273.28.17801
   Espenshade PJ, 1999, J BIOL CHEM, V274, P22795, DOI 10.1074/jbc.274.32.22795
   Ferré P, 2007, HORM RES, V68, P72, DOI 10.1159/000100426
   Foufelle F, 2002, BIOCHEM J, V366, P377, DOI 10.1042/BJ20020430
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Goldstein BJ, 2005, ANTIOXID REDOX SIGN, V7, P1021, DOI 10.1089/ars.2005.7.1021
   HUA XX, 1993, P NATL ACAD SCI USA, V90, P11603, DOI 10.1073/pnas.90.24.11603
   Igata M, 2005, CIRC RES, V97, P837, DOI 10.1161/01.RES.0000185823.73556.06
   Kaneto H, 2005, J MOL MED, V83, P429, DOI 10.1007/s00109-005-0640-x
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Nohturfft A, 1998, J BIOL CHEM, V273, P17243, DOI 10.1074/jbc.273.27.17243
   Seo JH, 2005, MOL BIOL CELL, V16, P348, DOI 10.1091/mbc.E04-05-0369
   Shimano H, 2001, PROG LIPID RES, V40, P439, DOI 10.1016/S0163-7827(01)00010-8
   Shimomura I, 1997, J CLIN INVEST, V99, P838, DOI 10.1172/JCI119247
   Tilg H, 2006, NAT REV IMMUNOL, V6, P772, DOI 10.1038/nri1937
   TONTONOZ P, 1993, MOL CELL BIOL, V13, P4753, DOI 10.1128/MCB.13.8.4753
   Wang HY, 2005, J CELL SCI, V118, P3905, DOI 10.1242/jcs.02513
NR 23
TC 142
Z9 152
U1 6
U2 35
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD OCT 31
PY 2008
VL 375
IS 4
BP 602
EP 607
DI 10.1016/j.bbrc.2008.08.068
PG 6
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 356HL
UT WOS:000259769200023
PM 18727921
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Liu, Y
   Zhai, MM
   Guo, F
   Shi, TR
   Liu, JZ
   Wang, X
   Zhang, XD
   Jing, D
   Hai, CX
AF Liu, Ying
   Zhai, Mingming
   Guo, Fan
   Shi, Tengrui
   Liu, Jiangzheng
   Wang, Xin
   Zhang, Xiaodi
   Jing, Da
   Hai, Chunxu
TI Whole Body Vibration Improves Insulin Resistance in db/db Mice:
   Amelioration of Lipid Accumulation and Oxidative Stress
SO APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
LA English
DT Article
DE Insulinresistance; Liver steatosis; Oxidative stress; Glutathione
   peroxidases; Whole body vibration
ID TYPE-2 DIABETES-MELLITUS; FATTY LIVER-DISEASE; GLUTATHIONE PEROXIDASES;
   METABOLIC SYNDROME; WEIGHT-GAIN; EXERCISE; ACTIVATION; THERAPY; RISK;
   RATS
AB Insulin resistance (IR) is the hallmark of type 2 diabetes mellitus (T2DM), which is one of the most important chronic noncommunicable diseases. Effective and feasible strategies to treat IR are still urgently needed. Previous research studies reported that whole body vibration (WBV) was beneficial for IR in clinical; however, its underlying mechanisms remains unknown. In the present study, db/db mice were treated with WBV administration 60 min/day for 12 weeks and the impaired insulin sensitivity was improved. Besides, liver steatosis was also ameliorated. Further explorations revealed that WBV could reduce the expression of SREBP1c and increase the expression of GSH-Px and consequently suppress oxidative stress. In conclusion, WBV attenuates oxidative stress to ameliorate liver steatosis and thus improves insulin resistance in db/db mice. Therefore, WBV administration is a promising treatment for individuals who suffered from central obesity and IR.
C1 [Liu, Ying; Shi, Tengrui; Liu, Jiangzheng; Wang, Xin; Zhang, Xiaodi; Hai, Chunxu] Fourth Mil Med Univ, Sch Publ Hlth, Dept Toxicol,Shanxi Prov Key Lab Free Rad Biol &, Minist Educ,Key Lab Hazard Assessment & Control S, Xian 710032, Shaanxi, Peoples R China.
   [Zhai, Mingming; Jing, Da] Fourth Mil Med Univ, Dept Biomed Engn, Xian 710032, Peoples R China.
   [Guo, Fan] Fourth Mil Med Univ, Xijing Hosp, Dept Radiol, Xian 710032, Peoples R China.
C3 Ministry of Education - China; Air Force Medical University; Air Force
   Medical University; Air Force Medical University
RP Hai, CX (corresponding author), Fourth Mil Med Univ, Sch Publ Hlth, Dept Toxicol,Shanxi Prov Key Lab Free Rad Biol &, Minist Educ,Key Lab Hazard Assessment & Control S, Xian 710032, Shaanxi, Peoples R China.; Jing, D (corresponding author), Fourth Mil Med Univ, Dept Biomed Engn, Xian 710032, Peoples R China.
EM jingdaasq@126.com; cx-hai@fmmu.edu.cn
RI Zhang, Xiaodi/KIB-3120-2024; shi, teng/GSE-5879-2022; Wang,
   Xin/AAJ-6869-2020; Wang, Xin/S-5548-2016
OI Wang, Xin/0000-0002-7296-9406; di, ming ming/0000-0001-9793-2231
FU Program for Chankiang Scholars, Innovative Research Team in University
   (PCSIRT); National Nature Scientific Foundation [NSFC-81473010,
   NSFC-3140040159]; Natural Science Foundation of Shaanxi Province
   [2014JQ4135]
FX This work was supported by Program for Chankiang Scholars, Innovative
   Research Team in University (PCSIRT) and National Nature Scientific
   Foundation (NSFC-81473010 and NSFC-3140040159). This work was also
   supported by the Natural Science Foundation of Shaanxi Province
   (2014JQ4135).
CR Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Almdal T, 2004, ARCH INTERN MED, V164, P1422, DOI 10.1001/archinte.164.13.1422
   Arciero PJ, 2014, J APPL PHYSIOL, V117, P1, DOI 10.1152/japplphysiol.00152.2014
   Arthur JR, 2000, CELL MOL LIFE SCI, V57, P1825
   Banerjee M, 2014, REDOX BIOL, V2, P170, DOI [10.1016/j.redox.2013.12.001, 10.4103/0971-6866.132747]
   Behboudi Lale, 2011, Asian J Sports Med, V2, P83
   Belavy DL, 2014, INT J OBESITY, V38, P1478, DOI 10.1038/ijo.2014.26
   Bellia A, 2014, INT J SPORTS MED, V35, P511, DOI 10.1055/s-0033-1354358
   CHAN JM, 1994, DIABETES CARE, V17, P961, DOI 10.2337/diacare.17.9.961
   Chen Y, 2013, FOOD CHEM TOXICOL, V60, P38, DOI 10.1016/j.fct.2013.07.008
   Choudhury S., 2015, FREE RADICAL RES, P1
   Cintra DE, 2012, LIFE SCI, V91, P395, DOI 10.1016/j.lfs.2012.08.002
   COLDITZ GA, 1995, ANN INTERN MED, V122, P481, DOI 10.7326/0003-4819-122-7-199504010-00001
   Pozo-Cruz B, 2014, MATURITAS, V77, P52, DOI 10.1016/j.maturitas.2013.09.005
   Demirtas CY, 2015, EUR REV MED PHARMACO, V19, P1915
   Feng RB, 2015, CHIN MED-UK, V10, DOI 10.1186/s13020-015-0054-9
   Forgione MA, 2002, AM J PHYSIOL-HEART C, V282, pH1255, DOI 10.1152/ajpheart.00598.2001
   Guo R, 2015, HEPATOB PANCREAT DIS, V14, P139, DOI 10.1016/S1499-3872(15)60355-1
   Hassan HA, 2015, APPL BIOCHEM BIOTECH, V176, P647, DOI 10.1007/s12010-015-1602-6
   Johnson NA, 2012, SEMIN LIVER DIS, V32, P65, DOI 10.1055/s-0032-1306427
   Kahler W, 1993, Z Gesamte Inn Med, V48, P223
   Kessler NJ, 2013, J BODYW MOV THER, V17, P518, DOI 10.1016/j.jbmt.2013.03.001
   Kim H, 2010, CYTOTECHNOLOGY, V62, P245, DOI 10.1007/s10616-010-9285-x
   Kopprasch S., 2015, CLIN ENDOCRINOLOGY O
   Kumar AK, 2015, APPL BIOCHEM BIOTECH, V175, P410, DOI 10.1007/s12010-014-1276-5
   Liu W., 2015, CURRENT DRUG TARGETS
   Lu C., 2015, CURCUMIN ATTENUATES
   Marosi K, 2012, NEUROSCIENCE, V226, P21, DOI 10.1016/j.neuroscience.2012.09.001
   MEISTER A, 1991, PHARMACOL THERAPEUT, V51, P155, DOI 10.1016/0163-7258(91)90076-X
   Murase T, 2005, AM J PHYSIOL-REG I, V288, pR708, DOI 10.1152/ajpregu.00693.2004
   Pischon T, 2008, NEW ENGL J MED, V359, P2105, DOI 10.1056/NEJMoa0801891
   Prabhakar R, 2006, BIOCHEMISTRY-US, V45, P6967, DOI 10.1021/bi060456e
   Rittweger J, 2010, EUR J APPL PHYSIOL, V108, P877, DOI 10.1007/s00421-009-1303-3
   Robertson RP, 2007, CELL BIOCHEM BIOPHYS, V48, P139, DOI 10.1007/s12013-007-0026-5
   Ronikeili-Costa P, 2014, REHABILITATION REP, V2014, DOI DOI 10.1155/2014/628518
   SALMINEN A, 1983, EXP MOL PATHOL, V38, P380, DOI 10.1016/0014-4800(83)90077-1
   Sañudo B, 2013, EUR J APPL PHYSIOL, V113, P2245, DOI 10.1007/s00421-013-2654-3
   Sekiya M, 2008, BIOCHEM BIOPH RES CO, V375, P602, DOI 10.1016/j.bbrc.2008.08.068
   Subhapradha N, 2014, APPL BIOCHEM BIOTECH, V172, P9, DOI 10.1007/s12010-013-0499-1
   Sun XH, 2012, AM J PHYSIOL-GASTR L, V302, pG548, DOI 10.1152/ajpgi.00342.2011
   Tan Y, 2011, CLIN SCI, V120, P297, DOI 10.1042/CS20100441
   Tsedensodnom O, 2013, HEPATOLOGY, V58, P1210, DOI 10.1002/hep.26497
   URSINI F, 1995, METHOD ENZYMOL, V252, P38
   Wang X, 2015, INT J MOL SCI, V16, P16483, DOI 10.3390/ijms160716483
   Weinheimer-Haus EM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0091355
   Wild S, 2004, DIABETES CARE, V27, P1047, DOI 10.2337/diacare.27.5.1047
   Yoosefinejad AK, 2014, J BODYW MOV THER, V18, P82, DOI 10.1016/j.jbmt.2013.10.007
NR 47
TC 24
Z9 28
U1 1
U2 12
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0273-2289
EI 1559-0291
J9 APPL BIOCHEM BIOTECH
JI Appl. Biochem. Biotechnol.
PD JUL
PY 2016
VL 179
IS 5
BP 819
EP 829
DI 10.1007/s12010-016-2033-8
PG 11
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA DR2TC
UT WOS:000379755800010
PM 26945578
DA 2025-06-11
ER

PT J
AU Brietzke, E
   Kapczinski, F
   Grassi-Oliveira, R
   Grande, I
   Vieta, E
   McIntyre, RS
AF Brietzke, Elisa
   Kapczinski, Flavio
   Grassi-Oliveira, Rodrigo
   Grande, Iria
   Vieta, Eduard
   McIntyre, Roger S.
TI Insulin dysfunction and allostatic load in bipolar disorder
SO EXPERT REVIEW OF NEUROTHERAPEUTICS
LA English
DT Review
DE allostatic load; bipolar disorder; cognition; cytokines; early life
   stress; general medical comorbidities; HPA; insulin; neuroplasticity;
   oxidative stress
ID PITUITARY-ADRENAL AXIS; CORTICOTROPIN-RELEASING HORMONE; METABOLIC
   SYNDROME; SYNAPTIC PLASTICITY; COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE;
   HIPPOCAMPAL PLASTICITY; INFLAMMATORY MARKERS; CARDIOVASCULAR RISK;
   MEMORY IMPAIRMENTS
AB Bipolar disorder (BD) is associated with substantial morbidity, as well as premature mortality. Available evidence indicates that 'stress-sensitive' chronic medical disorders, such as cardiovascular disease, obesity and Type 2 diabetes mellitus, are critical mediators and/or moderators of BD. Changes in physiologic systems implicated in allostasis have been proposed to impact brain structures and neurocognition, as well as medical comorbidity in this population. For example, abnormalities in insulin physiology, for example, insulin resistance, hyperinsulinemia and central insulinopenia, are implicated as effectors of allostatic load in BD. Insulin's critical role in CNS physiological (e.g., neurotrophism and synaptic plasticity) and pathophysiological (e.g., neurocognitive deficits, pro-apoptosis and amyloid deposition) processes is amply documented. This article introduces the concept that insulin is a mediator of allostatic load in the BD and possibly a therapeutic target.
C1 [Brietzke, Elisa] Univ Sao Paulo, Inst Psychiat, Bipolar Disorder Program, Sao Paulo, Brazil.
   [Kapczinski, Flavio] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Bipolar Disorder Program, Porto Alegre, RS, Brazil.
   [Kapczinski, Flavio] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Lab Mol Psychiat, Porto Alegre, RS, Brazil.
   [Kapczinski, Flavio; Grassi-Oliveira, Rodrigo] INCT TM, Natl Inst Translat Med, Porto Alegre, RS, Brazil.
   [Grassi-Oliveira, Rodrigo] Pontificia Univ Catolica Rio Grande do Sul, Dev Cognit Neurosci Res Grp, Porto Alegre, RS, Brazil.
   [Grande, Iria; Vieta, Eduard] Univ Barcelona, IDIBAPS, Bipolar Disorders Program, CIBERSAM,Inst Clin Neurosci,Hosp Clin, Barcelona, Spain.
   [McIntyre, Roger S.] Univ Toronto, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.
C3 Universidade de Sao Paulo; Universidade Federal do Rio Grande do Sul;
   Hospital de Clinicas de Porto Alegre; Hospital de Clinicas de Porto
   Alegre; Universidade Federal do Rio Grande do Sul; Pontificia
   Universidade Catolica Do Rio Grande Do Sul; CIBER - Centro de
   Investigacion Biomedica en Red; CIBERSAM; University of Barcelona;
   Hospital Clinic de Barcelona; IDIBAPS; University of Toronto
RP Brietzke, E (corresponding author), Rua Prof Dr Ovidio Pires de Campos 785, BR-01060970 Sao Paulo, Brazil.
EM elisabrietzke@hotmail.com
RI Vieta, Eduard/Y-2919-2019; Grande, Iria/AAF-9342-2021; Brietzke,
   Elisa/G-9559-2012; McIntyre, Roger/AAU-1000-2020; Grassi-Oliveira,
   R/G-2623-2012; Grande, Iria/D-3072-2015; Vieta, Eduard/I-6330-2013;
   Kapczinski, Flavio/D-3175-2013
OI Grassi-Oliveira, Rodrigo/0000-0001-9911-5921; Grande,
   Iria/0000-0002-0137-0666; Vieta, Eduard/0000-0002-0548-0053; Kapczinski,
   Flavio/0000-0001-8738-856X
FU Stanley Medical Research Institute; National Alliance for Research on
   Schizophrenia and Depression (NARSAD); Eli Lilly; Janssen-Ortho; Shire;
   AstraZeneca; Pfizer; Bristol-Myers Squibb
FX Roger S McIntyre has received research grants from the Stanley Medical
   Research Institute, the National Alliance for Research on Schizophrenia
   and Depression (NARSAD), Eli Lilly, Janssen-Ortho, Shire, AstraZeneca
   and Pfizer. He is on the advisory boards for the following: AstraZeneca,
   Bristol-Myers Squibb, France Foundation, GlaxoSmithKline, Janssen-Ortho,
   Solvay/Wyeth, Eli Lilly, Organon, Lundbeck, Biovail, Pfizer, Shire,
   Schering-Plough and Merck, and on the speakers bureau for the following:
   Janssen-Ortho, Astra-Zeneca, Eli Lilly, Lundbeck, Biovail and Merck. He
   has also carried out CME activities for the following: AstraZeneca,
   Bristol-Myers Squibb, France Foundation, I3CME, Solvay/Wyeth,
   Physicians' Postgraduate Press, CME Outfitters, Optum Health,
   Schering-Plough, Merck and Eli Lilly and received travel funds from
   Bristol-Myers Squibb. The authors have no other relevant affiliations or
   financial involvement with any organization or entity with a financial
   interest in or financial conflict with the subject matter or materials
   discussed in the manuscript apart from those disclosed.
CR Alsuwaidan MT, 2009, NEUROMOL MED, V11, P328, DOI 10.1007/s12017-009-8079-9
   Angst F, 2002, J AFFECT DISORDERS, V68, P167, DOI 10.1016/S0165-0327(01)00377-9
   Bauer ME, 2010, NEUROIMMUNOMODULAT, V17, P192, DOI 10.1159/000258721
   Begum N, 2000, AM J PHYSIOL-CELL PH, V278, pC81, DOI 10.1152/ajpcell.2000.278.1.C81
   Benedict C, 2004, PSYCHONEUROENDOCRINO, V29, P1326, DOI 10.1016/j.psyneuen.2004.04.003
   Bermejo P, 2008, IMMUNOL LETT, V117, P198, DOI 10.1016/j.imlet.2008.02.002
   Borrell LN, 2011, J EPIDEMIOL COMMUN H, V65, P144, DOI 10.1136/jech.2009.098269
   Brietzke E, 2008, PROG NEURO-PSYCHOPH, V32, P1355, DOI 10.1016/j.pnpbp.2008.01.006
   Brietzke E, 2009, J AFFECT DISORDERS, V116, P214, DOI 10.1016/j.jad.2008.12.001
   Brown ES, 1999, NEUROPSYCHOPHARMACOL, V21, P474, DOI 10.1016/S0893-133X(99)00054-8
   Bruehl H, 2007, J CLIN ENDOCR METAB, V92, P2439, DOI 10.1210/jc.2006-2540
   Bruehl H, 2009, BRAIN RES, V1280, P186, DOI 10.1016/j.brainres.2009.05.032
   Brunet A, 2001, CURR OPIN NEUROBIOL, V11, P297, DOI 10.1016/S0959-4388(00)00211-7
   Calkin C, 2009, BIPOLAR DISORD, V11, P650, DOI 10.1111/j.1399-5618.2009.00730.x
   Castilla-Puentes R, 2007, BIPOLAR DISORD, V9, P772, DOI 10.1111/j.1399-5618.2007.00534.x
   Cotman CW, 2002, TRENDS NEUROSCI, V25, P295, DOI 10.1016/S0166-2236(02)02143-4
   Craft S, 2004, LANCET NEUROL, V3, P169, DOI 10.1016/S1474-4422(04)00681-7
   Craft S, 2009, ARCH NEUROL-CHICAGO, V66, P300, DOI 10.1001/archneurol.2009.27
   Cunha AB, 2008, EUR ARCH PSY CLIN N, V258, P300, DOI 10.1007/s00406-007-0797-0
   Daban C, 2005, PSYCHIAT CLIN N AM, V28, P469, DOI 10.1016/j.psc.2005.01.005
   Dias VV, 2009, J AFFECT DISORDERS, V113, P285, DOI 10.1016/j.jad.2008.05.011
   Dugan LL, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005518
   During MJ, 2003, NAT MED, V9, P1173, DOI 10.1038/nm919
   Etain B, 2008, BIPOLAR DISORD, V10, P867, DOI 10.1111/j.1399-5618.2008.00635.x
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   Fagiolini A, 2003, AM J PSYCHIAT, V160, P112, DOI 10.1176/appi.ajp.160.1.112
   Fagiolini A, 2002, J CLIN PSYCHIAT, V63, P528, DOI 10.4088/JCP.v63n0611
   Fiedorowicz JG, 2008, ANN CLIN PSYCHIATRY, V20, P131, DOI 10.1080/10401230802177722
   Gallagher P, 2007, SCHIZOPHR RES, V90, P258, DOI 10.1016/j.schres.2006.11.020
   Garcia-Portilla MP, 2008, J AFFECT DISORDERS, V106, P197, DOI 10.1016/j.jad.2007.06.002
   Garno JL, 2005, BRIT J PSYCHIAT, V186, P121, DOI 10.1192/bjp.186.2.121
   Glaser R, 2005, NAT REV IMMUNOL, V5, P243, DOI 10.1038/nri1571
   Gold SM, 2007, DIABETOLOGIA, V50, P711, DOI 10.1007/s00125-007-0602-7
   Goldstein BI, 2009, J CLIN PSYCHIAT, V70, P1078, DOI 10.4088/JCP.08r04505
   Goldstein BI, 2009, BIPOLAR DISORD, V11, P657, DOI 10.1111/j.1399-5618.2009.00735.x
   Gomes FA, 2010, ACTA NEUROPSYCHIATR, V22, P63, DOI 10.1111/j.1601-5215.2010.00452.x
   Goodwin RD, 2004, PSYCHOL MED, V34, P509, DOI 10.1017/S003329170300134X
   Grassi-Oliveira R, 2008, REV BRAS PSIQUIATR, V30, P60, DOI 10.1590/S1516-44462008000100012
   Grillo CA, 2005, NEUROSCIENCE, V136, P477, DOI 10.1016/j.neuroscience.2005.08.019
   Grodstein F, 2001, DIABETES CARE, V24, P1060, DOI 10.2337/diacare.24.6.1060
   Gruenewald TL, 2006, P NATL ACAD SCI USA, V103, P14158, DOI 10.1073/pnas.0606215103
   Halliwell B, 2006, J NEUROCHEM, V97, P1634, DOI 10.1111/j.1471-4159.2006.03907.x
   Hallschmid M, 2009, DIABETOLOGIA, V52, P2264, DOI 10.1007/s00125-009-1501-x
   Hasselbalch SG, 1999, DIABETES, V48, P1915, DOI 10.2337/diabetes.48.10.1915
   Heim C, 2001, BIOL PSYCHIAT, V49, P1023, DOI 10.1016/S0006-3223(01)01157-X
   Hong M, 1997, J BIOL CHEM, V272, P19547, DOI 10.1074/jbc.272.31.19547
   Hunsberger JG, 2009, BRAIN RES, V1293, P76, DOI 10.1016/j.brainres.2009.06.103
   Iwai T, 2009, NEUROSCI RES, V64, P67, DOI 10.1016/j.neures.2009.01.013
   Jandeleit-Dahm K, 2008, CURR PHARM DESIGN, V14, P979, DOI 10.2174/138161208784139684
   Juster RP, 2010, NEUROSCI BIOBEHAV R, V35, P2, DOI 10.1016/j.neubiorev.2009.10.002
   Kapczinski F, 2008, REV BRAS PSIQUIATR, V30, P243, DOI 10.1590/S1516-44462008000300011
   Kapczinski F, 2008, NEUROSCI BIOBEHAV R, V32, P675, DOI 10.1016/j.neubiorev.2007.10.005
   Kapczinski Flavio, 2008, Expert Rev Neurother, V8, P1101, DOI 10.1586/14737175.8.7.1101
   Karavanaki K, 2008, J ENDOCRINOL INVEST, V31, P406, DOI 10.1007/BF03346384
   Karlamangla AS, 2006, PSYCHOSOM MED, V68, P500, DOI 10.1097/01.psy.0000221270.93985.82
   Kauer-Sant'Anna M, 2008, BRIT J PSYCHIAT, V192, P458, DOI 10.1192/bjp.bp.107.040295
   Kauer-Sant'Anna M, 2009, INT J NEUROPSYCHOPH, V12, P447, DOI 10.1017/S1461145708009310
   Kaufman D, 2007, DIABETES, V56, P1382, DOI 10.2337/db06-1409
   Ketter Terrence A, 2010, J Clin Psychiatry, V71, pe14, DOI 10.4088/JCP.8125tx11c
   Kim B, 2009, PSYCHIAT INVEST, V6, P78, DOI 10.4306/pi.2009.6.2.78
   Kishida KT, 2007, ANTIOXID REDOX SIGN, V9, P233, DOI 10.1089/ars.2007.9.233
   Knijff EM, 2007, BIPOLAR DISORD, V9, P743, DOI 10.1111/j.1399-5618.2007.00444.x
   Koponen H, 2008, J CLIN PSYCHIAT, V69, P178, DOI 10.4088/JCP.v69n0202
   Kramer AF, 2003, J MOL NEUROSCI, V20, P213, DOI 10.1385/JMN:20:3:213
   Kroner Z, 2009, ALTERN MED REV, V14, P373
   Kulstad JJ, 2006, NEUROLOGY, V66, P1506, DOI 10.1212/01.wnl.0000216274.58185.09
   Kunz M, 2008, PROG NEURO-PSYCHOPH, V32, P1677, DOI 10.1016/j.pnpbp.2008.07.001
   Kupfer DJ, 2005, JAMA-J AM MED ASSOC, V293, P2528, DOI 10.1001/jama.293.20.2528
   Lannert H, 1998, BEHAV NEUROSCI, V112, P1199, DOI 10.1037/0735-7044.112.5.1199
   Leverich GS, 2006, LANCET, V367, P1040, DOI 10.1016/S0140-6736(06)68450-X
   Levine A, 2007, PHYSIOL BEHAV, V90, P43, DOI 10.1016/j.physbeh.2006.08.025
   Li L, 2007, BRAIN RES REV, V56, P384, DOI 10.1016/j.brainresrev.2007.09.001
   Liu XP, 2010, EUR J PHARMACOL, V629, P153, DOI 10.1016/j.ejphar.2009.11.059
   Luchsinger JA, 2004, NEUROLOGY, V63, P1187, DOI 10.1212/01.WNL.0000140292.04932.87
   Lyons David M, 2002, Psychopharmacol Bull, V36, P27
   Maes M, 1997, PSYCHIAT RES, V66, P1, DOI 10.1016/S0165-1781(96)02915-0
   Magariños AM, 2000, P NATL ACAD SCI USA, V97, P11056, DOI 10.1073/pnas.97.20.11056
   Maggio M, 2006, J GERONTOL A-BIOL, V61, P575, DOI 10.1093/gerona/61.6.575
   Martínez-Arán A, 2004, BIPOLAR DISORD, V6, P224, DOI 10.1111/j.1399-5618.2004.00111.x
   McClean PL, 2010, EUR J PHARMACOL, V630, P158, DOI 10.1016/j.ejphar.2009.12.023
   McEwen Bruce S, 2006, Dialogues Clin Neurosci, V8, P367
   McEwen BS, 2007, PHYSIOL REV, V87, P873, DOI 10.1152/physrev.00041.2006
   McEwen BS, 2006, METABOLISM, V55, pS20, DOI 10.1016/j.metabol.2006.07.008
   McEwen BS, 2010, ANN NY ACAD SCI, V1186, P190, DOI 10.1111/j.1749-6632.2009.05331.x
   McEwen BS, 2010, HORM BEHAV, V57, P105, DOI 10.1016/j.yhbeh.2009.09.011
   McEwen BS, 1999, ANN NY ACAD SCI, V896, P30, DOI 10.1111/j.1749-6632.1999.tb08103.x
   McEwen BS, 2005, J PSYCHIATR NEUROSCI, V30, P315
   McEwen BS, 2003, HORM BEHAV, V43, P2, DOI 10.1016/S0018-506X(02)00024-7
   McEwen BS, 2002, NEUROBIOL AGING, V23, P921, DOI 10.1016/S0197-4580(02)00027-1
   McIntyre Roger S, 2006, Expert Opin Pharmacother, V7, P1305, DOI 10.1517/14656566.7.10.1305
   McIntyre Roger S, 2007, Ann Clin Psychiatry, V19, P257, DOI 10.1080/10401230701653377
   McIntyre RS, 2007, CURR OPIN PSYCHIATR, V20, P406, DOI 10.1097/YCO.0b013e3281938102
   McIntyre RS, 2010, J AFFECT DISORDERS, V126, P366, DOI 10.1016/j.jad.2010.04.012
   McIntyre Roger S, 2009, J Clin Psychiatry, V70, pe17
   McNay EC, 2010, PHYSIOL BEHAV, V100, P234, DOI 10.1016/j.physbeh.2010.01.004
   Midei AJ, 2010, PSYCHOSOM MED, V72, P215, DOI 10.1097/PSY.0b013e3181cb5c24
   Mir M, 2008, J NEUROIMMUNOL, V204, P101, DOI 10.1016/j.jneuroim.2008.07.002
   Mokdad AH, 2003, JAMA-J AM MED ASSOC, V289, P76, DOI 10.1001/jama.289.1.76
   Murray DP, 2009, CURR PSYCHIAT REP, V11, P475, DOI 10.1007/s11920-009-0072-3
   Pajonk FG, 2010, ARCH GEN PSYCHIAT, V67, P133, DOI 10.1001/archgenpsychiatry.2009.193
   Park CR, 2000, PHYSIOL BEHAV, V68, P509, DOI 10.1016/S0031-9384(99)00220-6
   Rao JS, 2010, MOL PSYCHIATR, V15, P384, DOI 10.1038/mp.2009.47
   Rapp MA, 2006, ARCH GEN PSYCHIAT, V63, P161, DOI 10.1001/archpsyc.63.2.161
   Rasgon NL, 2010, BIPOLAR DISORD, V12, P504, DOI 10.1111/j.1399-5618.2010.00839.x
   Rasgon NL, 2010, THESCIENTIFICWORLDJO, V10, P321, DOI 10.1100/tsw.2010.32
   Rasgon NL, 2005, NEUROBIOL AGING, V26, pS103
   Reagan LP, 2007, CURR OPIN PHARMACOL, V7, P633, DOI 10.1016/j.coph.2007.10.012
   Reger MA, 2008, NEUROLOGY, V70, P440, DOI 10.1212/01.WNL.0000265401.62434.36
   Reger MA, 2008, J ALZHEIMERS DIS, V13, P323, DOI 10.3233/jad-2008-13309
   Rodgers EE, 2002, INT J DEV NEUROSCI, V20, P187, DOI 10.1016/S0736-5748(02)00047-3
   Rosmond R, 2005, PSYCHONEUROENDOCRINO, V30, P1, DOI 10.1016/j.psyneuen.2004.05.007
   Ruzickova M, 2003, CAN J PSYCHIAT, V48, P458, DOI 10.1177/070674370304800705
   Ryan CM, 2000, DIABETES CARE, V23, P1486, DOI 10.2337/diacare.23.10.1486
   Sagud M, 2009, PSYCHIAT RES, V168, P218, DOI 10.1016/j.psychres.2008.06.048
   Scheid MP, 2003, FEBS LETT, V546, P108, DOI 10.1016/S0014-5793(03)00562-3
   Schmatz R, 2009, EUR J PHARMACOL, V610, P42, DOI 10.1016/j.ejphar.2009.03.032
   Seaquist ER, 2001, DIABETES, V50, P2203, DOI 10.2337/diabetes.50.10.2203
   Seeman T, 2010, ANN NY ACAD SCI, V1186, P223, DOI 10.1111/j.1749-6632.2009.05341.x
   Serrano F, 2004, AGEING RES REV, V3, P431, DOI 10.1016/j.arr.2004.05.002
   Sicras A, 2008, BIPOLAR DISORD, V10, P607, DOI 10.1111/j.1399-5618.2008.00599.x
   Steen E, 2005, J ALZHEIMERS DIS, V7, P63, DOI 10.3233/jad-2005-7107
   Sterling P., 1988, Handbook of life stress, cognition, and health, P629
   Storz P, 2002, FRONT BIOSCI-LANDMRK, V7, pD886, DOI 10.2741/storz
   Strachan MWJ, 1997, DIABETES CARE, V20, P438, DOI 10.2337/diacare.20.3.438
   Sugimoto K, 2008, CURR PHARM DESIGN, V14, P953, DOI 10.2174/138161208784139774
   Takuma K, 2004, PROG NEUROBIOL, V72, P111, DOI 10.1016/j.pneurobio.2004.02.001
   Teicher MH, 2006, AM J PSYCHIAT, V163, P993, DOI 10.1176/appi.ajp.163.6.993
   Thomas C, 2008, PEDIATRICS, V121, pE1240, DOI 10.1542/peds.2007-2403
   van der Heide LP, 2006, PROG NEUROBIOL, V79, P205, DOI 10.1016/j.pneurobio.2006.06.003
   van der Heide LP, 2005, J NEUROCHEM, V94, P1158, DOI 10.1111/j.1471-4159.2005.03269.x
   Vanhaesebroeck B, 2000, BIOCHEM J, V346, P561, DOI 10.1042/0264-6021:3460561
   Vega GL, 2001, AM HEART J, V142, P1108, DOI 10.1067/mhj.2001.119790
   Vieta E, 1999, PSYCHOL MED, V29, P971, DOI 10.1017/S0033291799008727
   Vieta E, 1997, ACTA PSYCHIAT SCAND, V95, P205, DOI 10.1111/j.1600-0447.1997.tb09621.x
   Von Korff M, 2009, PAIN, V143, P76, DOI 10.1016/j.pain.2009.01.034
   Watson GS, 2004, EUR J PHARMACOL, V490, P97, DOI 10.1016/j.ejphar.2004.02.048
   Watson S, 2004, BRIT J PSYCHIAT, V184, P496, DOI 10.1192/bjp.184.6.496
   White MF, 2002, AM J PHYSIOL-ENDOC M, V283, pE413, DOI 10.1152/ajpendo.00514.2001
   Yamaguchi A, 2001, J BIOL CHEM, V276, P5256, DOI 10.1074/jbc.M008552200
   YAO PL, 2009, PSYCHIAT RES, V174, P223
   Zhao WQ, 1999, J BIOL CHEM, V274, P34893, DOI 10.1074/jbc.274.49.34893
   Zhao WQ, 2004, EUR J PHARMACOL, V490, P71, DOI 10.1016/j.ejphar.2004.02.045
NR 142
TC 56
Z9 59
U1 0
U2 27
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1473-7175
EI 1744-8360
J9 EXPERT REV NEUROTHER
JI Expert Rev. Neurother.
PD JUL
PY 2011
VL 11
IS 7
BP 1017
EP 1028
DI 10.1586/ERN.10.185
PG 12
WC Clinical Neurology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 806YL
UT WOS:000293853900016
PM 21721918
OA Green Published
DA 2025-06-11
ER

PT J
AU Ge, DL
   Dong, YB
   Wang, XL
   Treiber, FA
   Snieder, H
AF Ge, Dongliang
   Dong, Yanbin
   Wang, Xiaoling
   Treiber, Frank A.
   Snieder, Harold
TI The Georgia Cardiovascular Twin Study: Influence of genetic
   predisposition and chronic stress on risk for cardiovascular disease and
   type 2 diabetes
SO TWIN RESEARCH AND HUMAN GENETICS
LA English
DT Article
ID HEART-RATE-VARIABILITY; RESPIRATORY SINUS ARRHYTHMIA; AMBULATORY
   BLOOD-PRESSURE; PULSE-WAVE VELOCITY; METABOLIC SYNDROME; HERITABILITY;
   AMERICAN; IMPACT; MORTALITY; POLYMORPHISMS
AB The Georgia Cardiovascular Twin Study is a longitudinal study of biobehavioral antecedents of cardiovascular disease in youth and young adults, including around 500 twin pairs with roughly equal numbers of African Americans and European Americans. Focus of study includes the longitudinal change in relative influence of genetic and environmental factors (especially chronic stress) on development of risk factors for cardiovascular disease. Approaches include quantitative genetic modeling of phenotypic twin data as well as the examination of the influence of polymorphic variation in candidate genes and their potential interaction with environmental factors on these risk factors. Future work will expand the scope of the study to investigating the impact of chronic stress as measured by indices of the hypothalamus-pituitary-adrenal axis and the sympathetic nervous system on preclinical markers of cardiovascular disease, essential hypertension and type 2 diabetes.
C1 Med Coll Georgia, Georgia Prevent Inst, Dept Pediat, Augusta, GA 30912 USA.
   Kings Coll London, Twin Res & Genet Epidemiol Unit, London WC2R 2LS, England.
C3 University System of Georgia; Augusta University; University of London;
   King's College London
RP Snieder, H (corresponding author), Med Coll Georgia, Georgia Prevent Inst, Dept Pediat, Bldg HS-1640, Augusta, GA 30912 USA.
EM hsnieder@mcg.edu
RI Ge, Dongliang/GYJ-5489-2022
FU NHLBI NIH HHS [HL 56622, HL 69999] Funding Source: Medline
CR ASMAR R, 1995, HYPERTENSION, V26, P485, DOI 10.1161/01.HYP.26.3.485
   Barnes VA, 2004, AM J HYPERTENS, V17, P366, DOI 10.1016/j.amjhyper.2003.12.008
   Barnes VA, 2001, J PSYCHOSOM RES, V51, P597, DOI 10.1016/S0022-3999(01)00261-6
   Barnes VA, 2004, PSYCHOSOM MED, V66, P909, DOI 10.1097/01.psy.0000145902.91749.35
   BIGGER JT, 1993, CIRCULATION, V88, P927, DOI 10.1161/01.CIR.88.3.927
   Björntorp P, 1999, ANN NY ACAD SCI, V892, P297, DOI 10.1111/j.1749-6632.1999.tb07803.x
   BOOMSMA DI, 1990, ACTA GENET MED GEMEL, V39, P181, DOI 10.1017/S0001566000005419
   Busjahn A, 1998, AM J CARDIOL, V81, P755, DOI 10.1016/S0002-9149(97)01019-9
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   de Geus EJC, 2003, MED SCI SPORT EXER, V35, P1287, DOI 10.1249/01.MSS.0000079073.20399.11
   DEGEUS EJ, 2006, PSYCHOSOM MED, V68, pA5
   Dekker JM, 1997, AM J EPIDEMIOL, V145, P899, DOI 10.1093/oxfordjournals.aje.a009049
   GE D, 2005, GENETIC EPIDEMIOLOGY, V29, P30
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   HENRY JP, 1990, J HYPERTENS, V8, P783, DOI 10.1097/00004872-199009000-00001
   Iliadou A, 2005, TWIN RES HUM GENET, V8, P492, DOI 10.1375/twin.8.5.492
   Imumorin IG, 2005, CARDIOVASC TOXICOL, V5, P109, DOI 10.1385/CT:5:2:109
   Jackson R W, 2001, Twin Res, V4, P12, DOI 10.1375/twin.4.1.12
   KLEIGER RE, 1987, AM J CARDIOL, V59, P256, DOI 10.1016/0002-9149(87)90795-8
   Koertge J, 2003, AM J CARDIOL, V91, P1316, DOI 10.1016/S0002-9149(03)00320-5
   Kupper N, 2006, HYPERTENSION, V47, P948, DOI 10.1161/01.HYP.0000217521.79447.9a
   Kupper NHM, 2004, CIRCULATION, V110, P2792, DOI 10.1161/01.CIR.0000146334.96820.6E
   La Rovere MT, 2002, CIRCULATION, V106, P945, DOI 10.1161/01.CIR.0000027565.12764.E1
   Lu YH, 2006, AM J HYPERTENS, V19, P832, DOI 10.1016/j.amjhyper.2006.01.006
   McEwen BS, 1999, ANN NY ACAD SCI, V896, P30, DOI 10.1111/j.1749-6632.1999.tb08103.x
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   Reinhardt L, 1996, CARDIOLOGY, V87, P104, DOI 10.1159/000177071
   Safar H, 2002, ARCH MAL COEUR VAISS, V95, P1215
   SCHWARTZ PJ, 1988, CIRCULATION, V78, P969, DOI 10.1161/01.CIR.78.4.969
   Singh JP, 1999, CIRCULATION, V99, P2251, DOI 10.1161/01.CIR.99.17.2251
   Sinnreich R, 1999, HUM GENET, V105, P654, DOI 10.1007/s004390051158
   Snieder H, 2005, J HYPERTENS, V23, pS369
   Snieder H, 1997, PSYCHOPHYSIOLOGY, V34, P317, DOI 10.1111/j.1469-8986.1997.tb02402.x
   Snieder H, 2002, BIOL PSYCHOL, V61, P73, DOI 10.1016/S0301-0511(02)00053-4
   Snieder H, 2002, AM J HYPERTENS, V15, P973, DOI 10.1016/S0895-7061(02)02991-6
   Snieder H, 2002, TWIN RES, V5, P497, DOI 10.1375/136905202320906354
   Tsuji H, 1996, CIRCULATION, V94, P2850, DOI 10.1161/01.CIR.94.11.2850
   Wang XL, 2005, AM J CARDIOL, V96, P1168, DOI 10.1016/j.amjcard.2005.06.050
   Wang XL, 2005, PSYCHOSOM MED, V67, P16, DOI 10.1097/01.psy.0000146331.10104.d4
   Zhu HD, 2006, PEDIATR RES, V60, P440, DOI 10.1203/01.pdr.0000238250.64591.44
   Zhu HD, 2006, AM J HYPERTENS, V19, P61, DOI 10.1016/j.amjhyper.2005.07.007
NR 41
TC 28
Z9 29
U1 0
U2 8
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1832-4274
EI 1839-2628
J9 TWIN RES HUM GENET
JI Twin Res. Hum. Genet.
PD DEC
PY 2006
VL 9
IS 6
BP 965
EP 970
DI 10.1375/183242706779462877
PG 6
WC Genetics & Heredity; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Obstetrics & Gynecology
GA 122HO
UT WOS:000243216600045
PM 17254438
OA Bronze
DA 2025-06-11
ER

PT J
AU Huynh, VW
   Chiang, JJ
AF Huynh, Virginia W.
   Chiang, Jessica J.
TI Subjective Social Status and Adolescent Health: The Role of Stress and
   Sleep
SO YOUTH & SOCIETY
LA English
DT Article
DE status; health; sleep; stress; Latino; Asian
ID FUNCTIONAL SOMATIC SYMPTOMS; FAMILY SOCIOECONOMIC-STATUS;
   BLOOD-PRESSURE; METABOLIC SYNDROME; DURATION; INTERVENTION; ASSOCIATION;
   PREVALENCE; CHILDHOOD; AMERICANS
AB Despite adolescence being a period marked by significant social changes, research on social status focuses largely on adults. This study examined whether school and societal subjective social status (SSS) are differentially associated with adolescent health above and beyond objective socioeconomic status (SES), and explored pathways linking SSS to health. Latino (n = 169) and Asian American (n = 77) adolescents (M age = 17.23, SD = 0.74; 59% female) completed self-reports of SSS, sleep, stress, and somatic symptoms. Parents reported income and education. Blood pressure (BP) measurements were obtained. Results indicate that independent of objective SES, lower school SSS was associated with higher diastolic BP whereas lower societal SSS was associated with more somatic symptoms. Sleep disruptions and perceived stress mediated the association between societal SSS and somatic symptoms. Results suggest that SSS may be more important to adolescent health than objective SES. Furthermore, school and societal SSS may differentially affect indicators of health through different pathways.
C1 [Huynh, Virginia W.] Calif State Univ Northridge, Dept Child & Adolescent Dev, 18111 Nordhoff St, Northridge, CA 91330 USA.
   [Chiang, Jessica J.] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA USA.
C3 California State University System; California State University
   Northridge; University of California System; University of California
   Los Angeles
RP Huynh, VW (corresponding author), Calif State Univ Northridge, Dept Child & Adolescent Dev, 18111 Nordhoff St, Northridge, CA 91330 USA.
EM Virginia.huynh@csun.edu
OI huynh, virginia/0000-0002-9741-4482
CR Adler NE, 2000, HEALTH PSYCHOL, V19, P586, DOI 10.1037/0278-6133.19.6.586
   Altman NG, 2012, SLEEP MED, V13, P1261, DOI 10.1016/j.sleep.2012.08.005
   [Anonymous], 2014, Stress in America: Are teens adopting adults' stress habits?
   Becker SP, 2015, J YOUTH ADOLESCENCE, V44, P239, DOI 10.1007/s10964-014-0248-y
   Bei B, 2013, EARLY INTERV PSYCHIA, V7, P213, DOI 10.1111/j.1751-7893.2012.00382.x
   Bohman H, 2012, BMC PSYCHIATRY, V12, DOI 10.1186/1471-244X-12-90
   Bootzin RR, 2005, CLIN PSYCHOL REV, V25, P629, DOI 10.1016/j.cpr.2005.04.007
   Bromfenbrennner Urie., 1979, Ecology of Human Development: Experiments by Nature and Design
   Burford TI, 2013, ANN BEHAV MED, V46, P217, DOI 10.1007/s12160-013-9487-5
   Burke CA, 2010, J CHILD FAM STUD, V19, P133, DOI 10.1007/s10826-009-9282-x
   Buysse D J, 1989, Psychiatry Res, V28, P193
   Cain N, 2011, SLEEP MED, V12, P246, DOI 10.1016/j.sleep.2010.06.008
   Campo JV, 2012, J CHILD PSYCHOL PSYC, V53, P575, DOI 10.1111/j.1469-7610.2012.02535.x
   Chen E, 2013, ANNU REV CLIN PSYCHO, V9, P723, DOI 10.1146/annurev-clinpsy-050212-185634
   Cohen J., 1988, STAT POWER ANAL BEHA, DOI [10.4324/9780203771587, DOI 10.4324/9780203771587]
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Cohen S, 2007, JAMA-J AM MED ASSOC, V298, P1685, DOI 10.1001/jama.298.14.1685
   Cook S, 2003, ARCH PEDIAT ADOL MED, V157, P821, DOI 10.1001/archpedi.157.8.821
   Cornelissen VA, 2005, HYPERTENSION, V46, P667, DOI 10.1161/01.HYP.0000184225.05629.51
   Crone EA, 2012, NAT REV NEUROSCI, V13, P636, DOI 10.1038/nrn3313
   de Castro AB, 2010, J IMMIGR MINOR HEALT, V12, P659, DOI 10.1007/s10903-009-9258-3
   Demakakos P, 2008, SOC SCI MED, V67, P330, DOI 10.1016/j.socscimed.2008.03.038
   Dewald JF, 2010, SLEEP MED REV, V14, P179, DOI 10.1016/j.smrv.2009.10.004
   Doubeni CA, 2012, AM J PUBLIC HEALTH, V102, P680, DOI 10.2105/AJPH.2011.300158
   Erikson Erik, 1968, Identity: Youth and Crises
   Finkelstein DM, 2006, J ADOLESCENT HEALTH, V39, P678, DOI 10.1016/j.jadohealth.2006.04.011
   Franzini L, 2006, SOC SCI MED, V63, P788, DOI 10.1016/j.socscimed.2006.01.009
   Gallo LC, 2005, J PERS SOC PSYCHOL, V88, P386, DOI 10.1037/0022-3514.88.2.386
   GLENDINNING A, 1992, SOC SCI MED, V35, P679, DOI 10.1016/0277-9536(92)90006-C
   Goodman E, 2003, OBES RES, V11, P1018, DOI 10.1038/oby.2003.140
   Goodman E, 2001, PEDIATRICS, V108, DOI 10.1542/peds.108.2.e31
   Gustafsson PE, 2011, ANN EPIDEMIOL, V21, P103, DOI 10.1016/j.annepidem.2010.08.012
   Hanson MD, 2007, J BEHAV MED, V30, P263, DOI 10.1007/s10865-007-9098-3
   Irwin MR, 2015, ANNU REV PSYCHOL, V66, P143, DOI 10.1146/annurev-psych-010213-115205
   Javaheri S, 2008, CIRCULATION, V118, P1034, DOI 10.1161/CIRCULATIONAHA.108.766410
   Knutson KL, 2007, PEDIATRICS, V119, pE1056, DOI 10.1542/peds.2006-2597
   Kozlowska K, 2013, CURR OPIN PSYCHIATR, V26, P485, DOI 10.1097/YCO.0b013e3283642ca0
   Lantz PM, 2005, J HEALTH SOC BEHAV, V46, P274, DOI 10.1177/002214650504600305
   Lauderdale DS, 2008, EPIDEMIOLOGY, V19, P838, DOI 10.1097/EDE.0b013e318187a7b0
   Liu XC, 2000, SLEEP, V23, P27
   Mackinnon David P, 2004, Multivariate Behav Res, V39, P99
   Marco CA, 2012, BEHAV SLEEP MED, V10, P70, DOI 10.1080/15402002.2012.636298
   Matthews KA, 2011, ANNU REV PSYCHOL, V62, P501, DOI 10.1146/annurev.psych.031809.130711
   Mezick EJ, 2008, PSYCHOSOM MED, V70, P410, DOI 10.1097/PSY.0b013e31816fdf21
   Moore PJ, 2002, PSYCHOSOM MED, V64, P337, DOI 10.1097/00006842-200203000-00018
   Moseley L, 2009, SLEEP, V32, P334, DOI 10.1093/sleep/32.3.334
   Muntner P, 2004, JAMA-J AM MED ASSOC, V291, P2107, DOI 10.1001/jama.291.17.2107
   National High Blood Pressure Education Program, 2005, 4 REP DIAGN EV TREAT
   Parker Jennifer D., 1994, Annals of Epidemiology, V4, P271
   Pina AA, 2004, J CLIN CHILD ADOLESC, V33, P227, DOI 10.1207/s15374424jccp3302_3
   Preacher KJ, 2008, BEHAV RES METHODS, V40, P879, DOI 10.3758/BRM.40.3.879
   Quon EC, 2014, HEALTH PSYCHOL, V33, P433, DOI 10.1037/a0033716
   Reinehr T, 2006, METABOLISM, V55, P113, DOI 10.1016/j.metabol.2005.07.016
   Resnick MD, 1997, JAMA-J AM MED ASSOC, V278, P823, DOI 10.1001/jama.278.10.823
   Ritterman ML, 2009, SOC SCI MED, V68, P1843, DOI 10.1016/j.socscimed.2009.02.048
   Schreier HMC, 2013, PSYCHOL BULL, V139, P606, DOI 10.1037/a0029416
   Singh-Manoux A, 2005, PSYCHOSOM MED, V67, P855, DOI 10.1097/01.psy.0000188434.52941.a0
   Singh-Manoux A, 2003, SOC SCI MED, V56, P1321, DOI 10.1016/S0277-9536(02)00131-4
   Somerville LH, 2013, CURR DIR PSYCHOL SCI, V22, P121, DOI 10.1177/0963721413476512
   Udry J.R., 1998, NEW PERSPECTIVES ADO, DOI [10.1017/cbo9780511571138.009, DOI 10.1017/CBO9780511571138.009]
   Van Cauter E, 1999, ANN NY ACAD SCI, V896, P254, DOI 10.1111/j.1749-6632.1999.tb08120.x
   Varvogli L., 2011, Health Science Journal, V5, P74, DOI DOI 10.1080/02699930302287
   West P, 2010, SOC SCI MED, V70, P1246, DOI 10.1016/j.socscimed.2009.12.006
   Yu YX, 2007, SLEEP, V30, P1688, DOI 10.1093/sleep/30.12.1688
   Zimmet P, 2007, PEDIATR DIABETES, V8, P299, DOI 10.1111/j.1399-5448.2007.00271.x
NR 65
TC 18
Z9 21
U1 1
U2 38
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0044-118X
EI 1552-8499
J9 YOUTH SOC
JI Youth Soc.
PD OCT
PY 2018
VL 50
IS 7
BP 926
EP 946
DI 10.1177/0044118X16646028
PG 21
WC Social Issues; Social Sciences, Interdisciplinary; Sociology
WE Social Science Citation Index (SSCI)
SC Social Issues; Social Sciences - Other Topics; Sociology
GA GS1ON
UT WOS:000443298800004
DA 2025-06-11
ER

PT J
AU Yasui, N
   Nishiyama, E
   Juman, S
   Negishi, H
   Miki, T
   Yamori, Y
   Ikeda, K
AF Yasui, Naomi
   Nishiyama, Emi
   Juman, Sachiko
   Negishi, Hiroko
   Miki, Tomohiro
   Yamori, Yukio
   Ikeda, Katsumi
TI Caffeic acid phenethyl ester suppresses oxidative stress in 3T3-L1
   adipocytes
SO JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
LA English
DT Article
DE CAPE; adipocyte; ROS; 3T3-L1
ID METABOLIC SYNDROME; DIFFERENTIATION; EXPRESSION; OBESITY
AB The generation of oxidative stress, characterized by enhanced reactive oxygen species (ROS) formation, has been found in obesity. ROS production was increased during the differentiation of 3T3-L1 cells into adipocytes. We previously reported that caffeic acid phenethyl ester (CAPE) suppresses 3T3-L1 differentiation to adipocytes through the inhibition of peroxisome proliferator-activated receptor . In this study, the preventive effect of CAPE on oxidative stress in 3T3-L1 cells was observed. The results were as follows: (1) ROS production during 3T3-L1 cell differentiation to adipocytes was significantly (p<0.05) suppressed by CAPE treatment in a concentration-dependent manner, (2) with CAPE treatment, the extracellular superoxide dismutase mRNA expression level significantly increased, but the NOX4 mRNA expression level did not change, and (3) CAPE treatment significantly increased superoxide dismutase (SOD) activity in 3T3-L1 cells. From these results, we suggest that the increased oxidative stress in 3T3-L1 differentiation to adipocytes is attenuated by CAPE treatment. This attenuation may be partly caused by increased SOD production.
C1 [Yasui, Naomi; Nishiyama, Emi; Juman, Sachiko; Miki, Tomohiro; Ikeda, Katsumi] Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Nishinomiya, Hyogo, Japan.
   [Negishi, Hiroko] Nara Womens Univ, Grad Sch Humanities & Sci, Nara 630, Japan.
   [Yamori, Yukio] Mukogawa Womens Univ, Inst World Hlth Dev, Nishinomiya, Hyogo, Japan.
C3 Mukogawa Women's University; Nara Womens University; Mukogawa Women's
   University
RP Ikeda, K (corresponding author), Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Nishinomiya, Hyogo, Japan.
EM ikeda@mukogawa-u.ac.jp
CR Abate N, 2000, J DIABETES COMPLICAT, V14, P154, DOI 10.1016/S1056-8727(00)00067-2
   Adachi T, 2009, REDOX REP, V14, P34, DOI 10.1179/135100009X392467
   Bedard K, 2007, PHYSIOL REV, V87, P245, DOI 10.1152/physrev.00044.2005
   Choi Y., 2000, J NUTR, V130, P3122
   Duvnjak L, 2009, J PHYSIOL PHARMACOL, V60, P19
   Farmer SR, 2004, OBES REV, V5, P186
   FRENKEL K, 1993, CANCER RES, V53, P1255
   Fu J, 2005, NEUROPHARMACOLOGY, V48, P1147, DOI 10.1016/j.neuropharm.2005.02.013
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   GAO Y, 2000, BIOL PHARM BULL, V31, P1716
   GRUNBERGER D, 1988, EXPERIENTIA, V44, P230, DOI 10.1007/BF01941717
   Han CY, 2012, J BIOL CHEM, V287, P10379, DOI 10.1074/jbc.M111.304998
   Juman S, 2012, BIOL PHARM BULL, V35, P1941, DOI 10.1248/bpb.b12-00317
   Juman S, 2010, BIOL PHARM BULL, V33, P1484, DOI 10.1248/bpb.33.1484
   Kameji H, 2010, NUTRITION, V26, P1151, DOI 10.1016/j.nut.2009.09.006
   Lee OH, 2010, BIOFACTORS, V36, P459, DOI 10.1002/biof.119
   Ntambi JM, 2000, J NUTR, V130, p3122S, DOI 10.1093/jn/130.12.3122S
   Ookawara T, 2002, BIOCHEM BIOPH RES CO, V296, P54, DOI 10.1016/S0006-291X(02)00804-5
   Sakuma S, 2010, J CLIN BIOCHEM NUTR, V47, P167, DOI 10.3164/jcbn.10-44
   Unger RH, 2001, DIABETES, V50, pS118, DOI 10.2337/diabetes.50.2007.S118
   Zhou Y, 2009, BIOL PHARM BULL, V32, P993, DOI 10.1248/bpb.32.993
NR 21
TC 17
Z9 18
U1 1
U2 23
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1028-6020
EI 1477-2213
J9 J ASIAN NAT PROD RES
JI J. Asian Nat. Prod. Res.
PD NOV 1
PY 2013
VL 15
IS 11
BP 1189
EP 1196
DI 10.1080/10286020.2013.825609
PG 8
WC Plant Sciences; Chemistry, Applied; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Chemistry; Pharmacology & Pharmacy
GA 270KC
UT WOS:000328316300008
PM 23927014
DA 2025-06-11
ER

PT J
AU Singh, R
   Singh, M
   Krishan, P
AF Singh, Randhir
   Singh, Manjeet
   Krishan, Pawan
TI Effect of Sodium Tungstate on Obesity Induced Cardiac Hypertrophy and
   Oxidative Stress
SO LATIN AMERICAN JOURNAL OF PHARMACY
LA English
DT Article
DE Obesity; Oxidative stress; Sodium tungstate
ID INTENTIONAL WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   ADIPOSE-TISSUE; HEART-FAILURE; RATS; HYPERTENSION; PATHOPHYSIOLOGY;
   THERMOGENESIS; PROTEINS
AB Obesity was induced by high fat diet (30 % fat by weight). Wistar rats of 225-250 g were kept on high fat diet to induce obesity for 90 days. Sodium tungstate (2 mg/ml, in drinking water) was administered for 90 days. Obesity was assessed by measuring % age change in body weight, WHR ratio, adiposity index and obesity index. Left ventricular cardiac hypertrophy was assessed in terms of left ventricular weight, left ventricular wall thickness, left ventricular protein content and left ventricular collagen content. Oxidative stress was measured in terms of levels of thiobarbituric acid reactive substances (TBARS), superoxide anion generation (SAG) and level of reduced glutathione. Sodium tungstate significantly attenuated the increase in body weight adiposity index, obesity index, TBARS, SAG and reduced glutathione, whereas no significant change was observed the parameters of cardiac hypertrophy. So, it can be concluded that sodium tungstate significantly attenuated high fat diet induced obesity and oxidative stress but no significant decrease was observed in the parameters of cardiac hypertrophy.
C1 [Singh, Randhir; Singh, Manjeet; Krishan, Pawan] Punjabi Univ, Dept Pharmaceut Sci & Drug Res, Patiala 147002, Punjab, India.
C3 Punjabi University
RP Singh, R (corresponding author), Punjabi Univ, Dept Pharmaceut Sci & Drug Res, Patiala 147002, Punjab, India.
EM dahiya_rsd@rediffmail.com
RI Dahiya, Randhir/AAF-6424-2020; Krishan, Pawan/AAF-9983-2021
OI Singh, Randhir/0000-0003-0183-0797
CR Aguila MB, 2003, NUTRITION, V19, P347, DOI 10.1016/S0899-9007(02)00934-6
   Alexander J K, 1993, Heart Dis Stroke, V2, P317
   Alpert MA, 2001, AM J MED SCI, V321, P225, DOI 10.1097/00000441-200104000-00003
   Balakumar Pitchai, 2007, Journal of Pharmacological and Toxicological Methods, V56, P1, DOI 10.1016/j.vascn.2007.01.003
   Balakumar P, 2006, BASIC CLIN PHARMACOL, V99, P418, DOI 10.1111/j.1742-7843.2006.pto_569.x
   Barbera A, 1997, DIABETOLOGIA, V40, P143, DOI 10.1007/s001250050655
   BEUTLER E, 1963, J LAB CLIN MED, V61, P882
   Ceconi C, 2003, ARCH BIOCHEM BIOPHYS, V420, P217, DOI 10.1016/j.abb.2003.06.002
   Claret M, 2005, ENDOCRINOLOGY, V146, P4362, DOI 10.1210/en.2005-0385
   Dalgaard LT, 2001, DIABETOLOGIA, V44, P946, DOI 10.1007/s001250100596
   Dobrian AD, 2001, HYPERTENSION, V37, P554, DOI 10.1161/01.HYP.37.2.554
   Dulloo AG, 2001, BIOCHEM SOC T, V29, P785, DOI 10.1042/BST0290785
   Engeli S, 2000, HYPERTENSION, V35, P1270, DOI 10.1161/01.HYP.35.6.1270
   GOLDSTEIN DJ, 1992, INT J OBESITY, V16, P397
   HIMMSHAGEN J, 1984, NEW ENGL J MED, V311, P1549, DOI 10.1056/NEJM198412133112407
   HUBERT HB, 1983, CIRCULATION, V67, P968, DOI 10.1161/01.CIR.67.5.968
   James PT, 2004, EUR J CARDIOV PREV R, V11, P3, DOI 10.1097/01.hjr.0000114707.27531.48
   Kenchaiah S, 2002, NEW ENGL J MED, V347, P305, DOI 10.1056/NEJMoa020245
   Kerner J, 2000, BBA-MOL CELL BIOL L, V1486, P1, DOI 10.1016/S1388-1981(00)00044-5
   LAUER MS, 1992, J AM COLL CARDIOL, V19, P130, DOI 10.1016/0735-1097(92)90063-S
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   Merkel M, 2002, J LIPID RES, V43, P1997, DOI 10.1194/jlr.R200015-JLR200
   Mori T, 2004, CARDIOVASC RES, V61, P771, DOI 10.1016/j.cardiores.2003.12.005
   Muñoz MC, 2001, DIABETES, V50, P131, DOI 10.2337/diabetes.50.1.131
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   PARTHASARATHY S, 2003, FREE RADICAL RES, V33, P197
   Roberts CK, 2006, METABOLISM, V55, P928, DOI 10.1016/j.metabol.2006.02.022
   Sadoshima J, 1997, ANNU REV PHYSIOL, V59, P551, DOI 10.1146/annurev.physiol.59.1.551
   Saleh MC, 2002, DIABETOLOGIA, V45, P174, DOI 10.1007/s00125-001-0737-x
   Santini SA, 1997, DIABETES, V46, P1853, DOI 10.2337/diabetes.46.11.1853
   Schrauwen P, 2002, J EXP BIOL, V205, P2275
   Simko F, 2002, PHYSIOL RES, V51, P27, DOI 10.33549/physiolres.930150
   Sjöström CD, 1999, OBES RES, V7, P477
   Storch J, 2000, BBA-MOL CELL BIOL L, V1486, P28, DOI 10.1016/S1388-1981(00)00046-9
   Vincent HK, 2006, INT J OBESITY, V30, P400, DOI 10.1038/sj.ijo.0803177
   Wang H, 1998, CIRC RES, V83, P832, DOI 10.1161/01.RES.83.8.832
   Williamson DF, 2000, DIABETES CARE, V23, P1499, DOI 10.2337/diacare.23.10.1499
   Wong CY, 2004, CIRCULATION, V110, P3081, DOI 10.1161/01.CIR.0000147184.13872.0F
   Woods SC, 2003, J NUTR, V133, P1081, DOI 10.1093/jn/133.4.1081
NR 39
TC 0
Z9 0
U1 0
U2 0
PU COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES
PI LA PLATA
PA DEPT CIENTIFICO, CALLE 5 NO 966, LA PLATA, 00000, ARGENTINA
SN 0326-2383
J9 LAT AM J PHARM
JI Lat. Am. J. Pharm.
PD AUG
PY 2010
VL 29
IS 5
BP 747
EP 753
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 654YW
UT WOS:000282208300016
DA 2025-06-11
ER

PT J
AU Yoshino, K
   Suzuki, S
   Ishizuka, Y
   Takayanagi, A
   Sugihara, N
   Kamijyo, H
AF Yoshino, Koichi
   Suzuki, Seitaro
   Ishizuka, Yoichi
   Takayanagi, Atsushi
   Sugihara, Naoki
   Kamijyo, Hideyuki
TI Relationship between job stress and subjective oral health symptoms in
   male financial workers in Japan
SO INDUSTRIAL HEALTH
LA English
DT Article
DE Oral health; Subjective symptoms; Job stress; BJSQ; Stress check
ID PERIODONTAL-DISEASE; METABOLIC SYNDROME; RISK-FACTORS
AB Objective: The aim was to assess subjective oral health symptoms and job stress, as measured by self-assessment of how demanding the job is, in male financial workers. Methods: The participants were recruited by applying screening procedures to a pool of Japanese registrants in an online database. For the stress check, 7 items about how demanding the job is were selected from The Brief Job Stress Questionnaire (BJSQ). Participants comprised a total of 950 financial male workers, ages 25 to 64. Results: Participants who answered "I can't complete my work in the required time" had more decayed teeth (p = 0.010). Participants who felt that their job is highly demanding (answered affirmatively to 6 or all 7 items) were more likely to report "often get food stuck between teeth" (p=0.030), "there are some foods I can't eat" (p=0.005), "bad breath" (p=0.032), and "jaw makes clicking sound" (p=0.032). The independent variable of total stress score of 24-28 was found to be correlated to at least three oral health symptoms (OR: 3.25; 95%CI: 1.66-6.35). Conclusion: These results indicate that certain job stress factors are associated with certain oral health symptoms, and that oral health symptoms are likely predictors of job stress.
C1 [Yoshino, Koichi; Suzuki, Seitaro; Ishizuka, Yoichi; Takayanagi, Atsushi; Sugihara, Naoki] Tokyo Dent Coll, Dept Epidemiol & Publ Hlth, Tokyo, Japan.
   [Kamijyo, Hideyuki] Tokyo Dent Coll, Dept Social Secur Dent, Tokyo, Japan.
C3 Tokyo Dental College; Tokyo Dental College
RP Yoshino, K (corresponding author), Tokyo Dent Coll, Dept Epidemiol & Publ Hlth, Tokyo, Japan.
EM ko-yoshi@d8.dion.ne.jp
RI Ishizuka, Yoichi/HPB-6409-2023
FU Research Fund for Clinical Study of Industrial Accidents and Diseases
   [140201-02]
FX This study was supported by the Research Fund for Clinical Study of
   Industrial Accidents and Diseases (140201-02).
CR Axelsson G, 1995, COMMUNITY DENT ORAL, V23, P365, DOI 10.1111/j.1600-0528.1995.tb00264.x
   Boyapati L, 2007, PERIODONTOL 2000, V44, P195, DOI 10.1111/j.1600-0757.2007.00211.x
   Dietrich T, 2015, J DENT RES, V94, P1369, DOI 10.1177/0022034515598961
   Donaldson AN, 2008, J DENT RES, V87, P60, DOI 10.1177/154405910808700110
   Edgar M., 2004, Saliva and oral health, V3rd
   FREEMAN R, 1993, COMMUNITY DENT ORAL, V21, P176, DOI 10.1111/j.1600-0528.1993.tb00748.x
   Fukui N, 2012, J PERIODONTOL, V83, P1363, DOI 10.1902/jop.2012.110605
   Genco RJ, 1999, J PERIODONTOL, V70, P711, DOI 10.1902/jop.1999.70.7.711
   Hugo FN, 2006, J PERIODONTOL, V77, P1008, DOI 10.1902/jop.2006.050037
   Kawakami N, 2016, J OCCUP HEALTH, V58, P1, DOI 10.1539/joh.15-0001-ER
   Kleinberg I, 2002, INT DENT J, V52, P236, DOI 10.1002/j.1875-595X.2002.tb00932.x
   Kuttila M, 1998, J OROFAC PAIN, V12, P67
   Linden GJ, 1996, J CLIN PERIODONTOL, V23, P675, DOI 10.1111/j.1600-051X.1996.tb00593.x
   Locker D, 2011, J PUBLIC HEALTH DENT, V71, P327, DOI 10.1111/j.1752-7325.2011.00277.x
   MARCENES WS, 1992, SOC SCI MED, V35, P1511
   Mejía-Rubalcava C, 2012, INT DENT J, V62, P127, DOI 10.1111/j.1875-595X.2011.00103.x
   Moss ME, 1996, J PERIODONTOL, V67, P1060, DOI 10.1902/jop.1996.67.10s.1060
   Oral Health Association, 2013, COMPR GUID SURV DENT, P16
   Peruzzo DC, 2007, J PERIODONTOL, V78, P1491, DOI 10.1902/jop.2007.060371
   Queiroz CS, 2002, EUR J ORAL SCI, V110, P337, DOI 10.1034/j.1600-0722.2002.21320.x
   Silva AER, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0106382
   Rivas-Tumanyan S, 2013, J PERIODONTOL, V84, P203, DOI 10.1902/jop.2012.110748
   Rollman G B, 2000, Curr Rev Pain, V4, P71
   Rugh JD, 1975, J CALIF DENT ASSOC, V3, P56
   Shimomitsu T.., 2000, The Ministry of Labor sponsored grant for the prevention of work-related illness: The 1999 report
   Sora ND, 2013, J CLIN PERIODONTOL, V40, P599, DOI 10.1111/jcpe.12104
   Stabholz A, 2010, PERIODONTOL 2000, V53, P138, DOI 10.1111/j.1600-0757.2010.00340.x
   Turner RJ, 2002, ORAL DIS, V8, P3, DOI 10.1034/j.1601-0825.2002.10815.x
   van Gelder MMHJ, 2010, AM J EPIDEMIOL, V172, P1292, DOI 10.1093/aje/kwq291
   Yasunaga Hideo, 2006, Nihon Koshu Eisei Zasshi, V53, P40
   Yuichi A, 2012, J DENT HLTH, V62, P41
NR 31
TC 8
Z9 8
U1 0
U2 11
PU NATL INST OCCUPATIONAL SAFETY & HEALTH, JAPAN
PI KAWASAKI KANAGAWA
PA 21-1 NAGAO 6-CHOME TAMA-KU, KAWASAKI KANAGAWA, 214, JAPAN
SN 0019-8366
EI 1880-8026
J9 IND HEALTH
JI Ind. Health
PD MAR
PY 2017
VL 55
IS 2
BP 119
EP 126
DI 10.2486/indhealth.2016-0120
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA EQ3XY
UT WOS:000398008500004
PM 27840370
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Mumford, EA
   Taylor, BG
   Kubu, B
AF Mumford, Elizabeth A.
   Taylor, Bruce G.
   Kubu, Bruce
TI Law Enforcement Officer Safety and Wellness
SO POLICE QUARTERLY
LA English
DT Article
DE law enforcement; occupational safety; officer health; critical
   incidents; PTSD
ID UNITED-STATES; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   ALCOHOL-CONSUMPTION; CIGARETTE-SMOKING; POLICE OFFICERS; PTSD SYMPTOMS;
   SHIFT WORK; PART I; STRESS
AB Officers in law enforcement agencies (LEAs) experience long-term health morbidity and mortality at rates exceeding other occupations and the general population. The purpose of this study was to pilot a survey of officer safety and wellness to demonstrate feasibility, assess the need for further research, and lay the groundwork for policies and additional support for officer wellbeing. A random sample of 184 officers from 11 participating LEAs responded to a survey regarding physical activity patterns, job characteristics, substance use, critical incidents, job-related stress, personal health, and health-care usage. Officers reported physical health outcomes at rates similar to the general population but screened positive for elevated rates of posttraumatic stress disorder, common mental disorders, and alcohol misuse. These data support the need for research at the regional and national levels to inform LEA policies and programs.
C1 [Mumford, Elizabeth A.; Taylor, Bruce G.] Univ Chicago, NORC, Bethesda, MD 20814 USA.
   [Kubu, Bruce] Police Execut Res Forum, Washington, DC USA.
C3 University of Chicago
RP Mumford, EA (corresponding author), Univ Chicago, NORC, 4350 East West Highway,Suite 800, Bethesda, MD 20814 USA.
EM mumford-elizabeth@norc.org
OI Taylor, Bruce/0000-0002-8115-1438
FU NORC at the University of Chicago; Police Executive Research Forum
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: NORC at the
   University of Chicago in collaboration with Police Executive Research
   Forum provided support for this study.
CR Abdollahi M., 2002, Journal of Forensic Psychology Practice, V2, P1, DOI DOI 10.1300/J158V02N02_01
   Abi-Habib N., 2004, 12 NSAF URB I
   Agaku Israel, 2012, Morbidity and Mortality Weekly Report, V61, P889
   Anderson GS, 2002, POLICING, V25, P399, DOI 10.1108/13639510210429437
   [Anonymous], 2009, Add Health Research Design
   [Anonymous], 2009, STRESS AM 2009
   Anshel MH, 2000, CRIM JUSTICE BEHAV, V27, P375, DOI 10.1177/0093854800027003006
   Ashton R.J., 2012, The Police Chief, V79, P62
   Auerbach SM, 2003, J CRIM JUST, V31, P25, DOI 10.1016/S0047-2352(02)00197-6
   BEEHR TA, 1995, J ORGAN BEHAV, V16, P3, DOI 10.1002/job.4030160104
   Board BJ, 2011, AM J IND MED, V54, P307, DOI 10.1002/ajim.20889
   Bradley KA, 2007, ALCOHOL CLIN EXP RES, V31, P1208, DOI 10.1111/j.1530-0277.2007.00403.x
   Brandl SG, 2012, POLICE Q, V15, P262, DOI 10.1177/1098611112447757
   Carlier IVE, 1997, J NERV MENT DIS, V185, P498, DOI 10.1097/00005053-199708000-00004
   Chae MH, 2013, POLICING, V36, P91, DOI 10.1108/13639511311302498
   Chen GX, 2007, AM J IND MED, V50, P285, DOI 10.1002/ajim.20441
   Chen GX, 2007, AM J IND MED, V50, P183, DOI 10.1002/ajim.20431
   Chopko BA, 2013, J LOSS TRAUMA, V18, P482, DOI 10.1080/15325024.2012.719340
   Church R.L., 1993, A Descriptive Analysis of Wellness Programs Within State Police Agencies and a Descriptive Analysis of Other State Police Agency Programs and The Texas Department of Public Safety
   Church RL, 1999, POLICING, V22, P304, DOI 10.1108/13639519910285062
   Claxton G., 2008, PUBLICATION KAISER F, V7790
   Commission on Accreditation for Law Enforcement Agencies, LAW ENF PROGR STAND
   Cooper D., 2005, Morbidity and Mortality Weekly Report, V54, P356
   Declercq F, 2011, J TRAUMA STRESS, V24, P133, DOI 10.1002/jts.20609
   Dollard MF, 2013, J ORGAN BEHAV, V34, P629, DOI 10.1002/job.1821
   Donnelly EA, 2014, J WORKPLACE BEHAV HE, V29, P333, DOI 10.1080/15555240.2014.965824
   Esquirol Y, 2009, CHRONOBIOL INT, V26, P544, DOI 10.1080/07420520902821176
   Fagan P, 2007, AM J PUBLIC HEALTH, V97, P1412, DOI 10.2105/AJPH.2006.103697
   Fan AZ, 2008, J CLIN ENDOCR METAB, V93, P3833, DOI 10.1210/jc.2007-2788
   Fent Kenneth W, 2010, J Occup Environ Hyg, V7, pD73, DOI 10.1080/15459624.2010.509843
   Franke WD, 1998, J OCCUP ENVIRON MED, V40, P441, DOI 10.1097/00043764-199805000-00006
   Friedman B, 2005, J AM GERIATR SOC, V53, P1978, DOI 10.1111/j.1532-5415.2005.00469.x
   Gillespie C., 2011, Morbidity and Mortality Weekly Report, V60, P103
   Gu JK, 2012, J OCCUP ENVIRON MED, V54, P1374, DOI 10.1097/JOM.0b013e31825f2bea
   Hamilton CM, 2011, AM J EPIDEMIOL, V174, P253, DOI 10.1093/aje/kwr193
   Harris CD, 2013, MMWR-MORBID MORTAL W, V62, P326
   HART PM, 1995, J OCCUP ORGAN PSYCH, V68, P133, DOI 10.1111/j.2044-8325.1995.tb00578.x
   Hartley Tara A, 2011, Int J Emerg Ment Health, V13, P211
   Hartley Tara A, 2007, Int J Emerg Ment Health, V9, P25
   Idler EL, 1997, J HEALTH SOC BEHAV, V38, P21, DOI 10.2307/2955359
   JOHNSON JV, 1988, AM J PUBLIC HEALTH, V78, P1336, DOI 10.2105/AJPH.78.10.1336
   Johnson LB, 2005, J FAM VIOLENCE, V20, P3, DOI 10.1007/s10896-005-1504-4
   Joseph PN, 2010, J OCCUP ENVIRON MED, V52, P1004, DOI 10.1097/JOM.0b013e3181f4385c
   Kanny Dafna, 2012, Morbidity and Mortality Weekly Report, V61, P14
   KARASEK RA, 1979, ADMIN SCI QUART, V24, P285, DOI 10.2307/2392498
   Kelly EL, 2008, ACAD MANAG ANN, V2, P305, DOI 10.1080/19416520802211610
   Kessler RC, 2005, ARCH GEN PSYCHIAT, V62, P593, DOI 10.1001/archpsyc.62.6.593
   Kroenke K, 2003, MED CARE, V41, P1284, DOI 10.1097/01.MLR.0000093487.78664.3C
   Kuklina E. V., 2011, Morbidity and Mortality Weekly Report, V60, P109
   LeBlanc V.R., 2008, International Journal of Stress Management, V15, P76, DOI [DOI 10.1037/1072-5245.15.1.76, 10.1037/1072-5245.15.1.76]
   Ma CC, 2013, AM J IND MED, V56, P1341, DOI 10.1002/ajim.22236
   Maguire BJ, 2002, ANN EMERG MED, V40, P625, DOI 10.1067/mem.2002.128681
   Martinez M., 2009, BJA PERF BODY ARMOR
   McCanlies EC, 2012, WORK, V43, P133, DOI 10.3233/WOR-2012-1399
   McEwen BS, 2006, METABOLISM, V55, pS20, DOI 10.1016/j.metabol.2006.07.008
   National Highway Traffic Safety Administration, 2000, TRAFF SAF NEW MILL S
   National Law Enforcement and Corrections Technology Center, 2008, NO REST WEARY
   National Law Enforcement Officers Memorial Fund, 2013, CAUS LAW ENF DEATHS
   National Law Enforcement Officers Memorial Fund, 2013, RES B
   Neylan TC, 2005, PSYCHONEUROENDOCRINO, V30, P373, DOI 10.1016/j.psyneuen.2004.10.005
   O'Hara Brett., 2012, Current Population Reports P, P70
   O'Keefe JH, 2007, J AM COLL CARDIOL, V50, P1009, DOI 10.1016/j.jacc.2007.04.089
   Ogden Cynthia L, 2013, NCHS Data Brief, P1
   Pacella ML, 2013, J ANXIETY DISORD, V27, P33, DOI 10.1016/j.janxdis.2012.08.004
   Patterson GT, 2003, J CRIM JUST, V31, P215, DOI 10.1016/S0047-2352(03)00003-5
   Pearsall B., 2012, NATL I JUSTICE J, V270, P36
   Prins A, 2003, PRIMARY CARE PSYCHIA, V9, P9
   Prochaska JJ, 2004, J ADOLESCENT HEALTH, V34, P163, DOI 10.1016/j.jadohealth.2003.07.001
   Rajaratnam SMW, 2011, JAMA-J AM MED ASSOC, V306, P2567, DOI 10.1001/jama.2011.1851
   Reaves B.A., 2012, Hiring and Retention of State and Local Law Enforcement Officers, 2008-Statistical Tables
   Regehr C, 2011, NEW HORIZ MANAG, P201
   Rehm J, 2003, J CARDIOVASC RISK, V10, P15, DOI 10.1097/00043798-200302000-00004
   Riediker M, 2007, INHAL TOXICOL, V19, P99, DOI 10.1080/08958370701495238
   Salmon P, 2001, CLIN PSYCHOL REV, V21, P33, DOI 10.1016/S0272-7358(99)00032-X
   Salters-Pedneault K, 2010, PERS INDIV DIFFER, V49, P210, DOI 10.1016/j.paid.2010.03.037
   Shane JM, 2010, J CRIM JUST, V38, P807, DOI 10.1016/j.jcrimjus.2010.05.008
   Shucard JL, 2012, PSYCHIAT RES-NEUROIM, V204, P25, DOI 10.1016/j.pscychresns.2012.04.006
   Slaven James E, 2011, Int J Emerg Ment Health, V13, P267
   Sonder GJB, 2005, AM J PREV MED, V28, P169, DOI 10.1016/j.amepre.2004.10.003
   Thompson MM., 2006, Int J Stress Manag, V13, P494, DOI [DOI 10.1037/1072-5245.13.4.494, 10.1037/1072-5245.13.4.494]
   VIOLANTI J, 1983, J OCCUP ENVIRON MED, V25, P455, DOI 10.1097/00043764-198306000-00010
   Violanti J.M., 2006, INT J STRESS MANAGE, V13, P541
   Violanti JM, 1998, AM J IND MED, V33, P366, DOI 10.1002/(SICI)1097-0274(199804)33:4<366::AID-AJIM6>3.0.CO;2-S
   Violanti JM, 2012, AM J IND MED, V55, P217, DOI 10.1002/ajim.22007
   Violanti JM, 2009, ARCH ENVIRON OCCUP H, V64, P194, DOI 10.1080/19338240903241259
   WARE JE, 1992, MED CARE, V30, P473, DOI 10.1097/00005650-199206000-00002
   Waxman R, 2000, SPINE, V25, P2085, DOI 10.1097/00007632-200008150-00013
   Weisburd D, 2001, ANN AM ACAD POLIT SS, V578, P50, DOI 10.1177/0002716201578001004
   Weiss DS, 2010, J TRAUMA STRESS, V23, P734, DOI 10.1002/jts.20576
   Witter RZ, 2007, J OCCUP ENVIRON HYG, V4, P895, DOI 10.1080/15459620701693516
   Wolk R, 2007, EXP PHYSIOL, V92, P67, DOI 10.1113/expphysiol.2006.033787
   Yoo SS, 2007, CURR BIOL, V17, pR877, DOI 10.1016/j.cub.2007.08.007
NR 92
TC 40
Z9 75
U1 0
U2 34
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1098-6111
EI 1552-745X
J9 POLICE Q
JI Police Q.
PD JUN
PY 2015
VL 18
IS 2
BP 111
EP 133
DI 10.1177/1098611114559037
PG 23
WC Criminology & Penology
WE Social Science Citation Index (SSCI)
SC Criminology & Penology
GA CH8HZ
UT WOS:000354278500001
DA 2025-06-11
ER

PT J
AU de Lemos, ET
   Oliveira, J
   Pinheiro, JP
   Reis, F
AF de Lemos, Edite Teixeira
   Oliveira, Jorge
   Pinheiro, Joao Pascoa
   Reis, Flavio
TI Regular Physical Exercise as a Strategy to Improve Antioxidant and
   Anti-Inflammatory Status: Benefits in Type 2 Diabetes Mellitus
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID INDUCED OXIDATIVE STRESS; INDUCED WEIGHT-LOSS; INSULIN-RESISTANCE;
   REACTIVE OXYGEN; ENDOTHELIAL FUNCTION; NITRIC-OXIDE; URIC-ACID;
   DENSITY-LIPOPROTEIN; NAD(P)H OXIDASE; FREE-RADICALS
AB Over the last 30 years the combination of both a sedentary lifestyle and excessive food availability has led to a significant increase in the prevalence of obesity and aggravation of rates of metabolic syndrome and type 2 diabetes mellitus (T2DM). Several lines of scientific evidence have been demonstrating that a low level of physical activity and decreased daily energy expenditure leads to the accumulation of visceral fat and, consequently, the activation of the oxidative stress/inflammation cascade, which underlies the development of insulin resistant T2DM and evolution of micro, and macrovascular complications. This paper focuses on the pathophysiological pathways associated with the involvement of oxidative stress and inflammation in the development of T2DM and the impact of regular physical exercise (training) as a natural antioxidant and anti-inflammatory strategy to prevent evolution of T2DM and its serious complications.
C1 [de Lemos, Edite Teixeira; Reis, Flavio] Univ Coimbra, Fac Med, IBILI, Lab Pharmacol & Expt Therapeut, P-3000354 Coimbra, Portugal.
   [de Lemos, Edite Teixeira; Oliveira, Jorge] Polytech Inst Viseu, ESAV, P-3504510 Viseu, Portugal.
   [Oliveira, Jorge] Polytech Inst Viseu, Ctr Study Educ Technol & Hlth, P-3504510 Viseu, Portugal.
C3 Universidade de Coimbra; Instituto Politecnico de Viseu; Instituto
   Politecnico de Viseu
RP Reis, F (corresponding author), Univ Coimbra, Fac Med, IBILI, Lab Pharmacol & Expt Therapeut, P-3000354 Coimbra, Portugal.
EM freis@fmed.uc.pt
RI Reis, Flávio/E-7077-2016; Teixeira-Lemos, Edite/AAW-9401-2021; Oliveira,
   Jorge/C-6443-2014
OI Pascoa Pinheiro, Joao/0000-0001-8666-1819; Teixeira-Lemos,
   Edite/0000-0002-6346-8319; Oliveira, Jorge/0000-0002-9391-5191; Reis,
   Flavio/0000-0003-3401-9554
CR Afanas'ev I, 2010, OXID MED CELL LONGEV, V3, P361, DOI 10.4161/oxim.3.6.14415
   Ahmadi N, 2011, AM J MED, V124, P978, DOI 10.1016/j.amjmed.2011.02.032
   Alessio HM, 2000, MED SCI SPORT EXER, V32, P1576
   Andersson AK, 2001, BIOCHEM BIOPH RES CO, V281, P396, DOI 10.1006/bbrc.2001.4361
   Bassuk SS, 2005, J APPL PHYSIOL, V99, P1193, DOI 10.1152/japplphysiol.00160.2005
   Bastard JP, 2006, EUR CYTOKINE NETW, V17, P4
   Belotto MF, 2010, CLIN EXP IMMUNOL, V162, P237, DOI 10.1111/j.1365-2249.2010.04240.x
   Bjork L, 2012, INT J SPORTS MED, V33, P279, DOI 10.1055/s-0032-1301891
   Bluher M, 2006, J CLIN ENDOCR METAB, V91, P2310, DOI 10.1210/jc.2005-2556
   Cai WJ, 2006, AM J NEPHROL, V26, P181, DOI 10.1159/000093122
   Caimi G, 2009, CLIN HEMORHEOL MICRO, V43, P233, DOI 10.3233/CH-2009-1215
   Calder PC, 2009, BRIT J NUTR, V101, pS1, DOI 10.1017/S0007114509377867
   Caro AA, 2004, ANNU REV PHARMACOL, V44, P27, DOI 10.1146/annurev.pharmtox.44.101802.121704
   Ceriello A, 2003, DIABETES CARE, V26, P1589, DOI 10.2337/diacare.26.5.1589
   Ceriello A, 2002, DIABETES, V51, P1076, DOI 10.2337/diabetes.51.4.1076
   Ceriello A, 2008, DIABETES, V57, P1349, DOI 10.2337/db08-0063
   Chang TS, 2004, J BIOL CHEM, V279, P41975, DOI 10.1074/jbc.M407707200
   Chen JS, 2011, ATHEROSCLEROSIS, V214, P301, DOI 10.1016/j.atherosclerosis.2010.11.010
   Cnop M, 2002, ENDOCRINOLOGY, V143, P3449, DOI 10.1210/en.2002-220273
   Cooper CE, 2002, BIOCHEM SOC T, V30, P280, DOI 10.1042/BST0300280
   Cortez-Pinto H, 2006, J HEPATOL, V44, P197, DOI 10.1016/j.jhep.2005.09.002
   Creager MA, 2003, CIRCULATION, V108, P1527, DOI 10.1161/01.CIR.0000091257.27563.32
   Dandona P, 2002, AM J CARDIOL, V90, p27G
   Dandona P, 2004, TRENDS IMMUNOL, V25, P4, DOI 10.1016/j.it.2003.10.013
   Das UN, 2004, NUTRITION, V20, P323, DOI 10.1016/j.nut.2003.11.017
   de Lemos ET, 2009, NUTRITION, V25, P330, DOI 10.1016/j.nut.2008.08.014
   de Lemos ET, 2007, MED SCI MONITOR, V13, pBR172
   de Lemos ET, 2011, MEDIAT INFLAMM, V2011, DOI 10.1155/2011/253061
   de Oliveira VN, 2012, APPL PHYSIOL NUTR ME, V37, P334, DOI [10.1139/h2012-004, 10.1139/H2012-004]
   DeFronzo RA, 2010, DIABETOLOGIA, V53, P1270, DOI 10.1007/s00125-010-1684-1
   Dela F, 2004, AM J PHYSIOL-ENDOC M, V287, pE1024, DOI 10.1152/ajpendo.00056.2004
   Donath MY, 2010, TRENDS ENDOCRIN MET, V21, P261, DOI 10.1016/j.tem.2009.12.010
   Dröge W, 2002, PHYSIOL REV, V82, P47, DOI 10.1152/physrev.00018.2001
   El-Assaad W, 2003, ENDOCRINOLOGY, V144, P4154, DOI 10.1210/en.2003-0410
   Enriquez A, 1999, BIOCHEM BIOPH RES CO, V255, P300, DOI 10.1006/bbrc.1999.0202
   Evans JL, 2002, ENDOCR REV, V23, P599, DOI 10.1210/er.2001-0039
   Fallon KE, 2001, BRIT J SPORT MED, V35, P170, DOI 10.1136/bjsm.35.3.170
   Fatehi-Hassanabad Z, 2010, EUR J PHARMACOL, V636, P8, DOI 10.1016/j.ejphar.2010.03.048
   Febbraio MA, 2002, FASEB J, V16, P1335, DOI 10.1096/fj.01-0876rev
   Ferrer MD, 2007, FREE RADICAL RES, V41, P274, DOI 10.1080/10715760601080371
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Finaud J, 2006, SPORTS MED, V36, P327, DOI 10.2165/00007256-200636040-00004
   Fisman EZ, 2010, CARDIOVASC DIABETOL, V9, DOI 10.1186/1475-2840-9-62
   Fridlyand LE, 2006, DIABETES OBES METAB, V8, P136, DOI 10.1111/j.1463-1326.2005.00496.x
   Fukai T, 2000, J CLIN INVEST, V105, P1631, DOI 10.1172/JCI9551
   Furler SM, 2006, OBESITY, V14, P228, DOI 10.1038/oby.2006.29
   Gao L, 2009, CARDIOVASC RES, V82, P9, DOI 10.1093/cvr/cvp031
   Giacco F, 2010, CIRC RES, V107, P1058, DOI 10.1161/CIRCRESAHA.110.223545
   Gleeson M, 2007, J APPL PHYSIOL, V103, P693, DOI 10.1152/japplphysiol.00008.2007
   Goebeler M, 2001, BLOOD, V97, P46, DOI 10.1182/blood.V97.1.46
   Golbidi S, 2012, EXP DIABETES RES, DOI 10.1155/2012/941868
   Golbidi S, 2010, MED SCI MONITOR, V16, pRA9
   Gomez-Cabrera MC, 2008, FREE RADICAL BIO MED, V44, P126, DOI 10.1016/j.freeradbiomed.2007.02.001
   Gomez-Cabrera MC, 2008, AM J CLIN NUTR, V87, P142, DOI 10.1093/ajcn/87.1.142
   Grijalva J, 2008, CARDIOVASC DIABETOL, V7, DOI 10.1186/1475-2840-7-34
   Gupta S, 2002, AM J PHYSIOL-CELL PH, V282, pC560, DOI 10.1152/ajpcell.00343.2001
   Guzik TJ, 2002, CIRCULATION, V105, P1656, DOI 10.1161/01.CIR.0000012748.58444.08
   Hambrecht R, 2003, CIRCULATION, V107, P3152, DOI 10.1161/01.CIR.0000074229.93804.5C
   Heitzer T, 2001, CIRCULATION, V104, P2673, DOI 10.1161/hc4601.099485
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Hollander J, 1999, AM J PHYSIOL-REG I, V277, pR856, DOI 10.1152/ajpregu.1999.277.3.R856
   Huang W, 2010, ARTERIOSCL THROM VAS, V30, P1542, DOI 10.1161/ATVBAHA.109.191189
   Hull RL, 2004, J CLIN ENDOCR METAB, V89, P3629, DOI 10.1210/jc.2004-0405
   Iborra RT, 2008, SCAND J MED SCI SPOR, V18, P742, DOI 10.1111/j.1600-0838.2007.00748.x
   Jankord R, 2004, MED SCI SPORT EXER, V36, P960, DOI 10.1249/01.MSS.0000128186.09416.18
   Jansen T, 2010, J MOL CELL CARDIOL, V49, P186, DOI 10.1016/j.yjmcc.2010.04.011
   Johnson RJ, 2003, HYPERTENSION, V41, P1183, DOI 10.1161/01.HYP.0000069700.62727.C5
   Kadowaki T, 2006, J CLIN INVEST, V116, P1784, DOI 10.1172/JCI29126
   Kaneto H, 2007, CURR MOL MED, V7, P674, DOI 10.2174/156652407782564408
   Kasapis C, 2005, J AM COLL CARDIOL, V45, P1563, DOI 10.1016/j.jacc.2004.12.077
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Keller C, 2004, BIOCHEM BIOPH RES CO, V321, P179, DOI 10.1016/j.bbrc.2004.06.129
   Kiritoshi S, 2003, DIABETES, V52, P2570, DOI 10.2337/diabetes.52.10.2570
   Kodama S, 2007, ARCH INTERN MED, V167, P999, DOI 10.1001/archinte.167.10.999
   Kriketos AD, 2004, DIABETES CARE, V27, P629, DOI 10.2337/diacare.27.2.629
   Lamb RE, 2008, INT J CLIN PRACT, V62, P1087, DOI 10.1111/j.1742-1241.2008.01789.x
   Lauer N, 2005, CARDIOVASC RES, V65, P254, DOI 10.1016/j.cardiores.2004.09.010
   Lazarevic G, 2006, DIABETES METAB, V32, P583, DOI 10.1016/S1262-3636(07)70312-9
   Lee HC, 2007, EXP BIOL MED, V232, P592
   Lee S, 2011, WORLD J CARDIOL, V3, P18, DOI 10.4330/wjc.v3.i1.18
   Leehey DJ, 2005, NEPHRON EXP NEPHROL, V100, pE46, DOI 10.1159/000084348
   Leeuwenburgh C, 2001, CURR MED CHEM, V8, P829, DOI 10.2174/0929867013372896
   Lieb DC, 2012, EXP DIABETES RES, DOI 10.1155/2012/878760
   Lindström J, 2003, DIABETES CARE, V26, P3230, DOI 10.2337/diacare.26.12.3230
   Lindström J, 2006, LANCET, V368, P1673, DOI 10.1016/S0140-6736(06)69701-8
   Madamanchi NR, 2005, ARTERIOSCL THROM VAS, V25, P950, DOI 10.1161/01.ATV.0000161050.77646.68
   Maedler K, 2001, DIABETES, V50, P69, DOI 10.2337/diabetes.50.1.69
   Mantel C, 2011, CURR OPIN HEMATOL, V18, P208, DOI 10.1097/MOH.0b013e3283475ffe
   Manzato E, 2007, INTERN EMERG MED, V2, P1, DOI 10.1007/s11739-007-0001-6
   Martin-Cordero L, 2009, EUR J APPL PHYSIOL, V107, P535, DOI 10.1007/s00421-009-1140-4
   Martín-Cordero L, 2011, NEUROIMMUNOMODULAT, V18, P123, DOI 10.1159/000322053
   Matsumoto S, 2003, FREE RADICAL RES, V37, P767, DOI 10.1080/1071576031000107344
   MATTHYS P, 1995, INFECT IMMUN, V63, P1158, DOI 10.1128/IAI.63.4.1158-1164.1995
   McGarry JD, 2002, DIABETES, V51, P7, DOI 10.2337/diabetes.51.1.7
   Minato K, 2000, INT J PANCREATOL, V27, P151, DOI 10.1385/IJGC:27:2:151
   Moien-Afshari F, 2008, DIABETOLOGIA, V51, P1327, DOI 10.1007/s00125-008-0996-x
   Monnier L, 2006, JAMA-J AM MED ASSOC, V295, P1681, DOI 10.1001/jama.295.14.1681
   Natarajan R, 2003, FRONT BIOSCI-LANDMRK, V8, pS783, DOI 10.2741/1144
   Niedowicz DM, 2005, CELL BIOCHEM BIOPHYS, V43, P289, DOI 10.1385/CBB:43:2:289
   Niess AM, 1999, FREE RADICAL BIO MED, V26, P184, DOI 10.1016/S0891-5849(98)00192-0
   Nishida Y, 2011, INTERNAL MED, V50, P2121, DOI 10.2169/internalmedicine.50.5506
   Nojima H, 2008, METABOLISM, V57, P170, DOI 10.1016/j.metabol.2007.08.021
   Oliveira CSV, 2011, ARQ BRAS ENDOCRINOL, V55, P446, DOI 10.1590/S0004-27302011000700003
   Ouchi N, 2000, CIRCULATION, V102, P1296, DOI 10.1161/01.CIR.102.11.1296
   Pacher P, 2007, PHYSIOL REV, V87, P315, DOI 10.1152/physrev.00029.2006
   Peake J, 2004, EXERC IMMUNOL REV, V10, P129
   Pedersen BK, 2007, BIOCHEM SOC T, V35, P1295, DOI 10.1042/BST0351295
   Pedersen BK, 2008, PHYSIOL REV, V88, P1379, DOI 10.1152/physrev.90100.2007
   Pedersen BK, 2009, J PHYSIOL-LONDON, V587, P5559, DOI 10.1113/jphysiol.2009.179515
   Pedersen BK, 2000, PHYSIOL REV, V80, P1055, DOI 10.1152/physrev.2000.80.3.1055
   Petersen AMW, 2005, J APPL PHYSIOL, V98, P1154, DOI 10.1152/japplphysiol.00164.2004
   Pickup JC, 2004, DIABETES CARE, V27, P813, DOI 10.2337/diacare.27.3.813
   Pitocco Dario, 2010, Rev Diabet Stud, V7, P15, DOI 10.1900/RDS.2010.7.15
   Pitocco D, 2009, DIABETES RES CLIN PR, V86, P173, DOI 10.1016/j.diabres.2009.09.019
   Poitout V, 2002, ENDOCRINOLOGY, V143, P339, DOI 10.1210/en.143.2.339
   Poitout V, 2008, ENDOCR REV, V29, P351, DOI 10.1210/er.2007-0023
   Rabin KR, 2005, EXPERT REV CARDIOVAS, V3, P465, DOI 10.1586/14779072.3.3.465
   Radák Z, 2000, ARCH BIOCHEM BIOPHYS, V383, P114, DOI 10.1006/abbi.2000.2042
   Rains JL, 2011, FREE RADICAL BIO MED, V50, P567, DOI 10.1016/j.freeradbiomed.2010.12.006
   Rawi S.M., 2011, Int. J. Pharm, V2, P29
   Rector RS, 2007, AM J PHYSIOL-ENDOC M, V293, pE500, DOI 10.1152/ajpendo.00116.2007
   Rhee SG, 2001, IUBMB LIFE, V52, P35, DOI 10.1080/15216540252774748
   Roberts CK, 2006, DIABETES RES CLIN PR, V73, P249, DOI 10.1016/j.diabres.2006.02.013
   Rolo AP, 2006, TOXICOL APPL PHARM, V212, P167, DOI 10.1016/j.taap.2006.01.003
   Sachdev S, 2008, FREE RADICAL BIO MED, V44, P215, DOI 10.1016/j.freeradbiomed.2007.07.019
   Saito T, 2011, ARCH INTERN MED, V171, P1352, DOI 10.1001/archinternmed.2011.275
   Sautin YY, 2008, NUCLEOS NUCLEOT NUCL, V27, P608, DOI 10.1080/15257770802138558
   Schmidt MI, 1999, LANCET, V353, P1649, DOI 10.1016/S0140-6736(99)01046-6
   Shanmugam N, 2004, DIABETES, V53, P795, DOI 10.2337/diabetes.53.3.795
   Shen GX, 2010, CAN J PHYSIOL PHARM, V88, P241, DOI 10.1139/Y10-018
   Shima K, 1997, DIABETES RES CLIN PR, V35, P11, DOI 10.1016/S0168-8227(96)01357-5
   Simpson KA, 2008, OBESITY, V16, P241, DOI 10.1038/oby.2007.53
   Slentz CA, 2009, DIABETES CARE, V32, P1807, DOI 10.2337/dc09-0032
   Starkie R, 2003, FASEB J, V17, P884, DOI 10.1096/fj.02-0670fje
   Stewart LK, 2007, MED SCI SPORT EXER, V39, P1714, DOI 10.1249/mss.0b013e31811ece1c
   Storz P, 2005, FRONT BIOSCI-LANDMRK, V10, P1881, DOI 10.2741/1667
   Taniyama Y, 2003, HYPERTENSION, V42, P1075, DOI 10.1161/01.HYP.0000100443.09293.4F
   Teixeira de Lemos E, 2007, B SPHM, P16
   Teixeira-Lemos E, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-12
   Thompson PD, 2001, MED SCI SPORT EXER, V33, pS438, DOI 10.1097/00005768-200106001-00012
   Timmerman KL, 2008, J LEUKOCYTE BIOL, V84, P1271, DOI 10.1189/jlb.0408244
   Tousoulis D, 2011, CURR PHARM DESIGN, V17, P4089, DOI 10.2174/138161211798764843
   Urso ML, 2003, TOXICOLOGY, V189, P41, DOI 10.1016/S0300-483X(03)00151-3
   van Raalte DH, 2011, DIABETES RES CLIN PR, V93, pS37, DOI 10.1016/S0168-8227(11)70012-2
   Venkateshappa C, 2012, NEUROCHEM RES, V37, P358, DOI 10.1007/s11064-011-0619-7
   Viña J, 2000, IUBMB LIFE, V49, P539
   Vincent HK, 2006, OBESITY, V14, P1921, DOI 10.1038/oby.2006.224
   Wang ZQ, 2003, BRIT J CLIN PHARMACO, V55, P77, DOI 10.1046/j.1365-2125.2003.01731.x
   Wellen KE, 2003, J CLIN INVEST, V112, P1785, DOI 10.1172/JCI20514
   Wilund KR, 2007, CLIN SCI, V112, P543, DOI 10.1042/CS20060368
   Wycherley TP, 2008, DIABETES OBES METAB, V10, P1062, DOI 10.1111/j.1463-1326.2008.00863.x
   Yang H, 2011, CLIN CHEM LAB MED, V49, P1773, DOI 10.1515/CCLM.2011.250
   Yang M, 2005, AM J HYPERTENS, V18, P1329, DOI 10.1016/j.amjhyper.2005.04.012
   Yano Y, 2004, DIABETES CARE, V27, P844, DOI 10.2337/diacare.27.3.844
   Yatagai T, 2003, ENDOCR J, V50, P233, DOI 10.1507/endocrj.50.233
   Yoon JC, 2010, GENE DEV, V24, P1507, DOI 10.1101/gad.1924910
   Yu ZW, 2012, WORLD J DIABETES, V3, P19, DOI 10.4239/wjd.v3.i1.19
   Zhang LF, 2003, CIRCULATION, V108, P472, DOI 10.1161/01.CIR.0000080378.96063.23
NR 158
TC 101
Z9 106
U1 0
U2 38
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2012
VL 2012
AR 741545
DI 10.1155/2012/741545
PG 15
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 997RT
UT WOS:000308184500001
PM 22928086
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Kokubun, K
AF Kokubun, Keisuke
TI Effort-Reward Imbalance and Passion Exploitation: A Narrative Review and
   a New Perspective
SO WORLD
LA English
DT Review
DE effort-reward imbalance; passion exploitation; intrinsic motivation;
   transformational leadership
ID CORONARY-HEART-DISEASE; WORK STRESS; MODEL; OVERCOMMITMENT;
   QUESTIONNAIRE; EMPOWERMENT; WORKPLACE
AB This paper provides a narrative review of previous research on effort-reward imbalance (ERI) and passion exploitation, providing a perspective for future research. Previous research has shown that ERI can cause work stress, negative economic behavior such as job turnover, and illnesses such as metabolic syndrome. Previous research also claims that loyal and generous people, as well as young people and women, are more likely to be targets of passion exploitation. However, there are unresolved issues in previous research, such as (i) the mechanism by which effort-reward imbalance leads to stress and illness, (ii) there being lack of research on what types of jobs are more likely to experience imbalance, and (iii) there being lack of research on what level of imbalance is acceptable, and therefore further research is required. To this end, this study recommends addressing these challenges through the integration of ERI and passion exploitation theory.
C1 [Kokubun, Keisuke] Kyoto Univ, Grad Sch Management, Kyoto 6068501, Japan.
C3 Kyoto University
RP Kokubun, K (corresponding author), Kyoto Univ, Grad Sch Management, Kyoto 6068501, Japan.
EM kokubun.keisuke.6x@kyoto-u.jp
RI Kokubun, Keisuke/H-9590-2018
OI Kokubun, Keisuke/0000-0002-7440-5049
CR Araújo TM, 2022, AM J IND MED, V65, P604, DOI 10.1002/ajim.23360
   Asakura M., 2022, CONSIDERING THIS PER
   Aulakh PS, 2000, IND MARKET MANAG, V29, P521, DOI 10.1016/S0019-8501(00)00126-7
   Bailey ER, 2024, SOC PSYCHOL PERS SCI, V15, P769, DOI 10.1177/19485506241252461
   Bass B. M., 1999, European Journal of Work and Organisational Psychology, V8, P9, DOI [DOI 10.1080/135943299398410, 10.1080/135943299398410]
   Bebenroth R, 2020, J INT MANAG, V26, DOI 10.1016/j.intman.2019.100730
   Beschoner P, 2023, PLOS ONE, V18, DOI 10.1371/journal.pone.0287509
   Boren JP, 2023, J OCCUP MED TOXICOL, V18, DOI 10.1186/s12995-023-00390-6
   Bozarslan R., 2024, Reading the Air: A Study on the Relationship Between Japans Overtime Work Culture and Universal Human Rights
   Braunheim L, 2024, SOC SCI MED, V341, DOI 10.1016/j.socscimed.2023.116523
   Chen SW, 2016, BRIT J NUTR, V115, P1254, DOI 10.1017/S0007114515005516
   Cho E, 2021, SOC SCI MED, V277, DOI 10.1016/j.socscimed.2021.113878
   Dobryakova E, 2013, J INT NEUROPSYCH SOC, V19, P849, DOI 10.1017/S1355617713000684
   Doki S, 2018, INT ARCH OCC ENV HEA, V91, P767, DOI 10.1007/s00420-018-1333-4
   Dragano N, 2017, EPIDEMIOLOGY, V28, P619, DOI 10.1097/EDE.0000000000000666
   Eddy P, 2023, PSYCHOSOM MED, V85, P450, DOI 10.1097/PSY.0000000000001155
   Elder EG, 2020, AUSTRALAS EMERG CARE, V23, P181, DOI 10.1016/j.auec.2020.02.002
   Fei Y, 2023, J CLIN NURS, V32, P4762, DOI 10.1111/jocn.16518
   Feuerhahn N, 2012, INT J STRESS MANAGE, V19, P105, DOI 10.1037/a0028338
   Fujimoto Y, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-14171-4
   Ge JJ, 2021, BMC PUBLIC HEALTH, V21, DOI 10.1186/s12889-021-10233-w
   Geurts SAE, 2005, WORK STRESS, V19, P319, DOI 10.1080/02678370500410208
   HACKMAN JR, 1975, J APPL PSYCHOL, V60, P159, DOI 10.1037/h0076546
   Heming M, 2023, J OCCUP MED TOXICOL, V18, DOI 10.1186/s12995-023-00376-4
   Honda Y., 2007, World, V762, P109
   IDASZAK JR, 1987, J APPL PSYCHOL, V72, P69, DOI 10.1037/0021-9010.72.1.69
   Jones MT, 2024, WORK STRESS, DOI 10.1080/02678373.2024.2364616
   Kim JY, 2020, J PERS SOC PSYCHOL, V118, P121, DOI 10.1037/pspi0000190
   Kokubun K, 2021, INQUIRY-J HEALTH CAR, V58, DOI 10.1177/00469580211005189
   Kostova T, 2018, J MANAGE, V44, P2611, DOI 10.1177/0149206316648383
   Kouvonen A, 2006, BMC PUBLIC HEALTH, V6, DOI 10.1186/1471-2458-6-24
   Kouvonen A, 2006, BMC PUBLIC HEALTH, V6, DOI 10.1186/1471-2458-6-251
   Kwon M., 2024, ACAD MANAGE REV, DOI [10.5465/amr.2021.0467, DOI 10.5465/AMR.2021.0467]
   Le Huu P, 2022, INT ARCH OCC ENV HEA, V95, P559, DOI 10.1007/s00420-021-01784-x
   Leineweber C, 2021, J OCCUP HEALTH, V63, DOI 10.1002/1348-9585.12203
   Li J, 2023, FRONT PSYCHOL, V14, DOI 10.3389/fpsyg.2023.1020494
   Livne-Ofer E, 2019, ACAD MANAGE J, V62, P1989, DOI 10.5465/amj.2017.1421
   Llorente-Alonso M, 2024, CURR PSYCHOL, V43, P1759, DOI 10.1007/s12144-023-04369-8
   Lopez-Gamundi P, 2021, NEUROSCI BIOBEHAV R, V131, P1275, DOI 10.1016/j.neubiorev.2021.10.024
   Lyons D., 2016, Disrupted: My misadventure in the start-up bubble
   Ma H, 2022, BMJ OPEN, V12, DOI 10.1136/bmjopen-2021-055941
   Mayerl H, 2021, ADV LIFE COURSE RES, V48, DOI 10.1016/j.alcr.2020.100394
   Min J, 2024, J BUS ETHICS, V190, P589, DOI 10.1007/s10551-023-05404-1
   National Association of Public Interest Corporations, 2024, Dictionary of Nonprofit Business Terms
   Nordentoft M, 2020, J PSYCHOSOM RES, V128, DOI 10.1016/j.jpsychores.2019.109867
   Nowak MA, 2005, NATURE, V437, P1291, DOI 10.1038/nature04131
   Nuebling M, 2013, BMC PUBLIC HEALTH, V13, DOI 10.1186/1471-2458-13-538
   O'Donovan R, 2020, BMC MED RES METHODOL, V20, DOI 10.1186/s12874-020-01066-z
   Pena-Gralle APB, 2022, SCAND J WORK ENV HEA, V48, P5, DOI 10.5271/sjweh.3987
   Peristera P, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2017-017525
   Pudelko M, 2013, ASIAN BUS MANAG, V12, P409, DOI 10.1057/abm.2013.6
   Ratey J., 2014, Go wild: Free your body and mind from the afflictions of civilization
   Reizer A, 2022, INT J STRESS MANAGE, V29, P205, DOI 10.1037/str0000251
   RIZZO JR, 1970, ADMIN SCI QUART, V15, P150, DOI 10.2307/2391486
   Ryan RM, 2000, CONTEMP EDUC PSYCHOL, V25, P54, DOI 10.1006/ceps.1999.1020
   Schaufeli WB, 2009, CROSS-CULT RES, V43, P320, DOI 10.1177/1069397109337239
   Schmidt B, 2015, INT J CARDIOL, V178, P24, DOI 10.1016/j.ijcard.2014.10.115
   Seedat S, 2021, BMJ-BRIT MED J, V374, DOI 10.1136/bmj.n1972
   Siegrist J, 2004, SOC SCI MED, V58, P1483, DOI 10.1016/S0277-9536(03)00351-4
   Siegrist J, 1996, J Occup Health Psychol, V1, P27, DOI 10.1037/1076-8998.1.1.27
   SIEGRIST J, 1986, SOC SCI MED, V22, P247, DOI 10.1016/0277-9536(86)90073-0
   Siegrist J., 2001, Stress in the workplace: Past, present and future, P52
   Siegrist J., 2016, Stress: Concepts, Cognition, Emotion, and Behavior, P81, DOI [10.1016/b978-0-12-800951-2.00009-1, 10.1016/B978-0-12-800951-2.00009-1, DOI 10.1016/B978-0-12-800951-2.00009-1]
   Siegrist J, 2008, SCAND J WORK ENV HEA, P163
   Siegrist J, 2016, INT J ENV RES PUB HE, V13, DOI 10.3390/ijerph13040432
   Siegrist J, 2009, INT ARCH OCC ENV HEA, V82, P1005, DOI 10.1007/s00420-008-0384-3
   SPREITZER GM, 1995, ACAD MANAGE J, V38, P1442, DOI 10.5465/256865
   Stanley ML, 2023, J EXP SOC PSYCHOL, V108, DOI 10.1016/j.jesp.2023.104503
   Stanley ML, 2023, J EXP SOC PSYCHOL, V106, DOI 10.1016/j.jesp.2022.104442
   THOMAS KW, 1990, ACAD MANAGE REV, V15, P666, DOI 10.2307/258687
   van der Meij L, 2018, PSYCHONEUROENDOCRINO, V89, P78, DOI 10.1016/j.psyneuen.2017.12.020
   Wolter C, 2021, J PUBLIC HEALTH-HEID, V29, P177, DOI 10.1007/s10389-019-01112-1
   Xu WX, 2009, J OCCUP HEALTH, V51, P107, DOI 10.1539/joh.L8060
   Yan YJ, 2021, COGN NEUROPSYCHIATRY, V26, P166, DOI 10.1080/13546805.2021.1899906
   Yu SF, 2015, WORK, V51, P411, DOI 10.3233/WOR-141881
   Zhang YJ, 2024, FRONT PSYCHOL, V15, DOI 10.3389/fpsyg.2024.1425445
   Zhao S., 2024, Chinese General Pract J, V1, P3, DOI [10.1016/j.cgpj.2024.03.004, DOI 10.1016/J.CGPJ.2024.03.004]
   Zhou H, 2015, J NURS MANAGE, V23, P96, DOI 10.1111/jonm.12094
   Zhuo LB, 2020, J AFFECT DISORDERS, V260, P214, DOI 10.1016/j.jad.2019.09.007
NR 79
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2673-4060
J9 WORLD-BASEL
JI World
PD DEC
PY 2024
VL 5
IS 4
BP 1235
EP 1247
DI 10.3390/world5040063
PG 13
WC Economics; Political Science; Social Sciences, Interdisciplinary
WE Emerging Sources Citation Index (ESCI)
SC Business & Economics; Government & Law; Social Sciences - Other Topics
GA Q8K5U
UT WOS:001387099000001
OA gold
DA 2025-06-11
ER

PT J
AU Bhatti, S
   Kozlov, S
   Farooqi, AA
   Naqi, A
   Lavin, M
   Khanna, KK
AF Bhatti, Shahzad
   Kozlov, Sergei
   Farooqi, Ammad Ahmad
   Naqi, Ali
   Lavin, Martin
   Khanna, Kum Kum
TI ATM protein kinase: the linchpin of cellular defenses to stress
SO CELLULAR AND MOLECULAR LIFE SCIENCES
LA English
DT Review
DE ATM kinase; DNA damage response; Signaling; Carcinogenesis
ID DOUBLE-STRAND BREAKS; DNA-DAMAGE RESPONSE; TELANGIECTASIA MUTATED ATM;
   S-PHASE CHECKPOINT; ATAXIA-TELANGIECTASIA; IONIZING-RADIATION; OXIDATIVE
   STRESS; DEPENDENT PHOSPHORYLATION; MRE11/RAD50/NBS1 COMPLEX;
   INSULIN-RESISTANCE
AB ATM is the most significant molecule involved in monitoring the genomic integrity of the cell. Any damage done to DNA relentlessly challenges the cellular machinery involved in recognition, processing and repair of these insults. ATM kinase is activated early to detect and signal lesions in DNA, arrest the cell cycle, establish DNA repair signaling and faithfully restore the damaged chromatin. ATM activation plays an important role as a barrier to tumorigenesis, metabolic syndrome and neurodegeneration. Therefore, studies of ATM-dependent DNA damage signaling pathways hold promise for treatment of a variety of debilitating diseases through the development of new therapeutics capable of modulating cellular responses to stress. In this review, we have tried to untangle the complex web of ATM signaling pathways with the purpose of pinpointing multiple roles of ATM underlying the complex phenotypes observed in AT patients.
C1 [Kozlov, Sergei; Lavin, Martin; Khanna, Kum Kum] Queensland Inst Med Res, QIMR, Brisbane, Qld 4029, Australia.
   [Bhatti, Shahzad; Farooqi, Ammad Ahmad; Naqi, Ali] Univ Lahore, Inst Mol Biol & Biotechnol, Lahore, Pakistan.
C3 QIMR Berghofer Medical Research Institute; University of Lahore
RP Kozlov, S (corresponding author), Queensland Inst Med Res, QIMR, 300 Herston Rd, Brisbane, Qld 4029, Australia.
EM Sergei.Kozlov@qimr.edu.au
RI Kozlov, Sergei/T-9779-2019; Khanna, Kum/I-1747-2013; Farooqi,
   Ammad/O-9760-2018; Lavin, Martin/F-5961-2014
OI Farooqi, Ammad/0000-0003-2899-5014; Bhatti, Shahzad/0000-0003-1937-0100;
   Khanna, Kum Kum/0000-0001-8650-5381; Lavin, Martin/0000-0002-5940-4769
FU National Health and Medical Research Council (NHMRC); Australian
   Research Council (ARC); Cancer Council Queensland (CCQ)
FX We apologize to our colleagues whose data have not been cited due to
   space limitations. The support by grants from the National Health and
   Medical Research Council (NHMRC), Australian Research Council (ARC) and
   Cancer Council Queensland (CCQ) is gratefully appreciated. We are
   thankful to Madeleine Kersting for excellent graphic artwork
   preparation, Dr Kevin Spring for useful comments and the editor for
   inviting this review.
CR Adams BR, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0010001
   AGUILAR MJ, 1968, J NEUROPATH EXP NEUR, V27, P659
   Aguilar-Quesada R, 2007, BMC MOL BIOL, V8, DOI 10.1186/1471-2199-8-29
   AHMAD MQF, 2010, WORLD J ONCOL, V1, P242
   Alexander A, 2010, P NATL ACAD SCI USA, V107, P4153, DOI 10.1073/pnas.0913860107
   Ali A, 2004, GENE DEV, V18, P249, DOI 10.1101/gad.1176004
   Allen DR, 2001, GENE DEV, V15, P554, DOI 10.1101/gad.869001
   Ambrose M, 2007, HUM MOL GENET, V16, P2154, DOI 10.1093/hmg/ddm166
   Andegeko Y, 2001, J BIOL CHEM, V276, P38224
   Anderson CM, 2008, GENE DEV, V22, P854, DOI 10.1101/gad.1646208
   Anne SL, 2007, J NEUROSCI, V27, P7318, DOI 10.1523/JNEUROSCI.1831-07.2007
   Armstrong L, 2010, STEM CELLS, V28, P661, DOI 10.1002/stem.307
   Ayoub N, 2008, NATURE, V453, P682, DOI 10.1038/nature06875
   Ayoub N, 2009, CELL CYCLE, V8, P2945
   Bakkenist CJ, 2003, NATURE, V421, P499, DOI 10.1038/nature01368
   Bandhakavi S, 2010, MOL CELL PROTEOMICS, V9, P403, DOI 10.1074/mcp.M900326-MCP200
   BANERJEE S, 1995, J CELL SCI, V108, P755
   Banin S, 1998, SCIENCE, V281, P1674, DOI 10.1126/science.281.5383.1674
   BAR RS, 1978, NEW ENGL J MED, V298, P1164, DOI 10.1056/NEJM197805252982103
   Barlow C, 2000, P NATL ACAD SCI USA, V97, P871, DOI 10.1073/pnas.97.2.871
   Barzilai A, 2002, DNA REPAIR, V1, P3, DOI 10.1016/S1568-7864(01)00007-6
   Barzilai A, 2008, DNA REPAIR, V7, P1010, DOI 10.1016/j.dnarep.2008.03.005
   Baskaran R, 1997, NATURE, V387, P516, DOI 10.1038/387516a0
   Beamish H, 2002, J BIOL CHEM, V277, P30515, DOI 10.1074/jbc.M203801200
   Bennetzen MV, 2010, MOL CELL PROTEOMICS, V9, P1314, DOI 10.1074/mcp.M900616-MCP200
   Bensimon A, 2010, SCI SIGNAL, V3, DOI 10.1126/scisignal.2001034
   Berkovich E, 2007, NAT CELL BIOL, V9, P683, DOI 10.1038/ncb1599
   Bhaskara V, 2007, MOL CELL, V25, P647, DOI 10.1016/j.molcel.2007.01.028
   Biton S, 2006, J BIOL CHEM, V281, P17482, DOI 10.1074/jbc.M601895200
   Bloch-Damti A, 2005, ANTIOXID REDOX SIGN, V7, P1553, DOI 10.1089/ars.2005.7.1553
   Boehrs JK, 2007, J NEUROCHEM, V100, P337, DOI 10.1111/j.1471-4159.2006.04254.x
   Boisvert FM, 2005, GENE DEV, V19, P671, DOI 10.1101/gad.1279805
   Bosotti R, 2000, TRENDS BIOCHEM SCI, V25, P225, DOI 10.1016/S0968-0004(00)01563-2
   Braunstein S, 2009, MOL CELL BIOL, V29, P5645, DOI 10.1128/MCB.00711-09
   Brewerton SC, 2004, J STRUCT BIOL, V145, P295, DOI 10.1016/j.jsb.2003.11.024
   Burdak-Rothkamm S, 2007, ONCOGENE, V26, P993, DOI 10.1038/sj.onc.1209863
   Buscemi G, 2001, MOL CELL BIOL, V21, P5214, DOI 10.1128/MCB.21.15.5214-5222.2001
   Cam H, 2010, MOL CELL, V40, P509, DOI 10.1016/j.molcel.2010.10.030
   Canman CE, 1998, SCIENCE, V281, P1677, DOI 10.1126/science.281.5383.1677
   Carlessi L, 2009, CELL DEATH DIFFER, V16, P795, DOI 10.1038/cdd.2009.10
   Carney JP, 1998, CELL, V93, P477, DOI 10.1016/S0092-8674(00)81175-7
   Carson CT, 2003, EMBO J, V22, P6610, DOI 10.1093/emboj/cdg630
   Cerosaletti K, 2004, J BIOL CHEM, V279, P38813, DOI 10.1074/jbc.M404294200
   Chailleux C, 2010, BIOCHEM J, V426, P365, DOI 10.1042/BJ20091329
   Chan DW, 2000, J BIOL CHEM, V275, P7803, DOI 10.1074/jbc.275.11.7803
   Chapman JR, 2008, EMBO REP, V9, P795, DOI 10.1038/embor.2008.103
   Chen BPC, 2007, J BIOL CHEM, V282, P6582, DOI 10.1074/jbc.M611605200
   Chen G, 1996, J BIOL CHEM, V271, P33693, DOI 10.1074/jbc.271.52.33693
   Chen P, 2003, J NEUROSCI, V23, P11453
   Chen XP, 2007, EXP CELL RES, V313, P1667, DOI 10.1016/j.yexcr.2007.02.015
   Chiu SL, 2010, NEURAL DEV, V5, DOI 10.1186/1749-8104-5-7
   Cohn MA, 2008, MOL CELL, V32, P306, DOI 10.1016/j.molcel.2008.10.009
   Costanzo V, 2004, PLOS BIOL, V2, P600, DOI 10.1371/journal.pbio.0020110
   Costes SV, 2007, PLOS COMPUT BIOL, V3, P1477, DOI 10.1371/journal.pcbi.0030155
   Cowell IG, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0001057
   Dames SA, 2005, J BIOL CHEM, V280, P20558, DOI 10.1074/jbc.M501116200
   Daniel JA, 2008, J CELL BIOL, V183, P777, DOI 10.1083/jcb.200805154
   DAVIS AJ, 2010, CELL CYCLE, V9
   de Jager M, 2001, MOL CELL, V8, P1129, DOI 10.1016/S1097-2765(01)00381-1
   de Lange T, 2005, GENE DEV, V19, P2100, DOI 10.1101/gad.1346005
   Denchi EL, 2007, NATURE, V448, P1068, DOI 10.1038/nature06065
   Deng YB, 2009, NATURE, V460, P914, DOI 10.1038/nature08196
   Desai-Mehta A, 2001, MOL CELL BIOL, V21, P2184, DOI 10.1128/MCB.21.6.2184-2191.2001
   Di Virgilio M, 2009, DNA REPAIR, V8, P1311, DOI 10.1016/j.dnarep.2009.07.006
   Dimitrova N, 2009, MOL CELL BIOL, V29, P5552, DOI 10.1128/MCB.00476-09
   Dong ZW, 1999, J BIOL CHEM, V274, P19513, DOI 10.1074/jbc.274.28.19513
   Douglas P, 2007, MOL CELL BIOL, V27, P1581, DOI 10.1128/MCB.01962-06
   Du LT, 2009, J EXP MED, V206, P2285, DOI 10.1084/jem.20081940
   Dupré A, 2006, NAT STRUCT MOL BIOL, V13, P451, DOI 10.1038/nsmb1090
   Durocher D, 2001, CURR OPIN CELL BIOL, V13, P225, DOI 10.1016/S0955-0674(00)00201-5
   Engmann O, 2010, J PROTEOME RES, V9, P2725, DOI 10.1021/pr900627e
   Falck J, 2002, NAT GENET, V30, P290, DOI 10.1038/ng845
   Falck J, 2005, NATURE, V434, P605, DOI 10.1038/nature03442
   Farooqi AA, 2011, J EXP INTEGR MED, V1, P43, DOI DOI 10.5455/JEIM.030111.OR.002
   Fernandes N, 2005, J BIOL CHEM, V280, P15158, DOI 10.1074/jbc.M412065200
   Frouin I, 2003, EMBO REP, V4, P666, DOI 10.1038/sj.embor.embor886
   Fu XA, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002009
   Gately DP, 1998, MOL BIOL CELL, V9, P2361, DOI 10.1091/mbc.9.9.2361
   Ghavidel A, 2001, CELL, V106, P575, DOI 10.1016/S0092-8674(01)00473-1
   Goldstine JV, 2006, DNA REPAIR, V5, P432, DOI 10.1016/j.dnarep.2005.12.002
   Goodarzi AA, 2004, EMBO J, V23, P4451, DOI 10.1038/sj.emboj.7600455
   Goodarzi AA, 2004, DNA REPAIR, V3, P753, DOI 10.1016/j.dnarep.2004.03.041
   Goodarzi AA, 2008, MOL CELL, V31, P167, DOI 10.1016/j.molcel.2008.05.017
   Grattarola M, 2003, INT J BIOL MACROMOL, V33, P23, DOI 10.1016/S0141-8130(03)00060-6
   Green CM, 2002, EMBO REP, V3, P28, DOI 10.1093/embo-reports/kvf005
   Guo JY, 2008, CURR BIOL, V18, P933, DOI 10.1016/j.cub.2008.05.045
   Guo Z, 2010, CELL CYCLE, V9, P4805, DOI 10.4161/cc.9.24.14323
   Guo Z, 2010, SCIENCE, V330, P517, DOI 10.1126/science.1192912
   Haince JF, 2007, J BIOL CHEM, V282, P16441, DOI 10.1074/jbc.M608406200
   Hauptner A, 2006, RADIAT PROT DOSIM, V122, P147, DOI 10.1093/rpd/ncl420
   Heierhorst J, 2008, CELL CYCLE, V7, P2654, DOI 10.4161/cc.7.17.6593
   Hinz M, 2010, MOL CELL, V40, P63, DOI 10.1016/j.molcel.2010.09.008
   Hoehn KL, 2009, P NATL ACAD SCI USA, V106, P17787, DOI 10.1073/pnas.0902380106
   Hopfner KP, 2000, CELL, V101, P789, DOI 10.1016/S0092-8674(00)80890-9
   Hopfner KP, 2002, NATURE, V418, P562, DOI 10.1038/nature00922
   Hopfner KP, 2001, CELL, V105, P473, DOI 10.1016/S0092-8674(01)00335-X
   Horejsi Z, 2010, MOL CELL, V39, P839, DOI 10.1016/j.molcel.2010.08.037
   HOULDSWORTH J, 1980, NUCLEIC ACIDS RES, V8, P3709, DOI 10.1093/nar/8.16.3709
   Huang TT, 2003, CELL, V115, P565, DOI 10.1016/S0092-8674(03)00895-X
   Hurov KE, 2010, GENE DEV, V24, P1939, DOI 10.1101/gad.1934210
   Iacovoni JS, 2010, EMBO J, V29, P1446, DOI 10.1038/emboj.2010.38
   Ikura T, 2007, MOL CELL BIOL, V27, P7028, DOI 10.1128/MCB.00579-07
   Innes CL, 2006, MOL CANCER RES, V4, P197, DOI 10.1158/1541-7786.MCR-05-0154
   Inomata K, 2009, CELL, V137, P1088, DOI 10.1016/j.cell.2009.03.037
   Ishikawa Y, 2005, CELL SIGNAL, V17, P1175, DOI 10.1016/j.cellsig.2005.03.025
   Ito K, 2006, NAT MED, V12, P446, DOI 10.1038/nm1388
   Ito K, 2004, NATURE, V431, P997, DOI 10.1038/nature02989
   Jazayeri A, 2006, NAT CELL BIOL, V8, P37, DOI 10.1038/ncb1337
   Jazayeri A, 2008, EMBO J, V27, P1953, DOI 10.1038/emboj.2008.128
   Jiang XF, 2006, J BIOL CHEM, V281, P15741, DOI 10.1074/jbc.M513172200
   Jiang YL, 2005, HUM MUTAT, V25, P56, DOI 10.1002/humu.20113
   Kaizuka T, 2010, J BIOL CHEM, V285, P20109, DOI 10.1074/jbc.M110.121699
   Kanu N, 2007, EMBO J, V26, P2933, DOI 10.1038/sj.emboj.7601733
   Karlseder J, 2004, PLOS BIOL, V2, P1150, DOI 10.1371/journal.pbio.0020240
   Keegan KS, 1996, GENE DEV, V10, P2423, DOI 10.1101/gad.10.19.2423
   Keller DM, 2001, MOL CELL, V7, P283, DOI 10.1016/S1097-2765(01)00176-9
   Khanna KK, 1997, J BIOL CHEM, V272, P9489
   Khanna KK, 1998, NAT GENET, V20, P398, DOI 10.1038/3882
   Kim J, 2009, STEM CELLS, V27, P1987, DOI 10.1002/stem.125
   Kim J, 2009, J BIOL CHEM, V284, P14396, DOI 10.1074/jbc.M808116200
   Kim JA, 2007, J CELL BIOL, V178, P209, DOI 10.1083/jcb.200612031
   Kim TS, 2010, DIS MODEL MECH, V3, P752, DOI 10.1242/dmm.004689
   Kim YC, 2009, NAT CELL BIOL, V11, P92, DOI 10.1038/ncb1817
   Kinner A, 2008, NUCLEIC ACIDS RES, V36, P5678, DOI 10.1093/nar/gkn550
   Kirshner J, 2006, CANCER RES, V66, P10861, DOI 10.1158/0008-5472.CAN-06-2565
   Kitagawa R, 2004, GENE DEV, V18, P1423, DOI 10.1101/gad.1200304
   KLEINSCHMIDT JA, 1991, EMBO J, V10, P3043, DOI 10.1002/j.1460-2075.1991.tb07855.x
   Kolas NK, 2007, SCIENCE, V318, P1637, DOI 10.1126/science.1150034
   KONDO N, 1993, SCAND J IMMUNOL, V38, P45, DOI 10.1111/j.1365-3083.1993.tb01692.x
   Kozlov S, 2003, J BIOL CHEM, V278, P9309, DOI 10.1074/jbc.M300003200
   Kozlov SV, 2006, EMBO J, V25, P3504, DOI 10.1038/sj.emboj.7601231
   Kozlov SV, 2011, J BIOL CHEM, V286, P9107, DOI 10.1074/jbc.M110.204065
   Kruhlak M, 2007, NATURE, V447, P730, DOI 10.1038/nature05842
   Kruhlak MJ, 2006, J CELL BIOL, V172, P823, DOI 10.1083/jcb.200510015
   Kumar A, 2010, P NATL ACAD SCI USA, V107, P7491, DOI 10.1073/pnas.0914242107
   Lavin MF, 2008, NAT REV MOL CELL BIO, V9, P759, DOI 10.1038/nrm2514
   Lavin MF, 2007, CELL CYCLE, V6, P931, DOI 10.4161/cc.6.8.4180
   Lechner MS, 2000, MOL CELL BIOL, V20, P6449, DOI 10.1128/MCB.20.17.6449-6465.2000
   Lee AYL, 2007, J BIOL CHEM, V282, P32243, DOI 10.1074/jbc.M705486200
   Lee HS, 2010, EMBO J, V29, P1434, DOI 10.1038/emboj.2010.27
   Lee JH, 2007, ONCOGENE, V26, P7741, DOI 10.1038/sj.onc.1210872
   Lee JH, 2004, SCIENCE, V304, P93, DOI 10.1126/science.1091496
   Lee JH, 2005, SCIENCE, V308, P551, DOI 10.1126/science.1108297
   Lee JH, 2010, EMBO J, V29, P574, DOI 10.1038/emboj.2009.372
   Lehner B, 2006, NAT GENET, V38, P896, DOI 10.1038/ng1844
   Lempiäinen H, 2009, EMBO J, V28, P3067, DOI 10.1038/emboj.2009.281
   Li DQ, 2010, J BIOL CHEM, V285, P19802, DOI 10.1074/jbc.M109.085258
   Li HY, 2008, J CELL BIOL, V183, P253, DOI 10.1083/jcb.200711150
   Li JL, 2009, CURR BIOL, V19, P2091, DOI 10.1016/j.cub.2009.10.039
   Li X, 2007, J BIOL CHEM, V282, P36177, DOI 10.1074/jbc.M706912200
   Li X, 2010, SCI SIGNAL, V3, DOI 10.1126/scisignal.2000781
   Lim ACB, 2004, J BIOL CHEM, V279, P46668, DOI 10.1074/jbc.M404760200
   Linding R, 2007, CELL, V129, P1415, DOI 10.1016/j.cell.2007.05.052
   Liu JJ, 2010, FEBS LETT, V584, P619, DOI 10.1016/j.febslet.2009.12.011
   Llorca O, 2003, ONCOGENE, V22, P3867, DOI 10.1038/sj.onc.1206649
   Lou ZK, 2006, MOL CELL, V21, P187, DOI 10.1016/j.molcel.2005.11.025
   Lovejoy CA, 2009, DNA REPAIR, V8, P1004, DOI 10.1016/j.dnarep.2009.04.006
   Lucero H, 2003, J BIOL CHEM, V278, P22136, DOI 10.1074/jbc.M301579200
   Macaulay VM, 2001, ONCOGENE, V20, P4029, DOI 10.1038/sj.onc.1204565
   Mao L, 2009, MOL CELL BIOL, V29, P5426, DOI 10.1128/MCB.00105-09
   Matsuoka S, 2007, SCIENCE, V316, P1160, DOI 10.1126/science.1140321
   Meetei AR, 2003, MOL CELL BIOL, V23, P3417, DOI 10.1128/MCB.23.10.3417-3426.2003
   Mimitou EP, 2009, DNA REPAIR, V8, P983, DOI 10.1016/j.dnarep.2009.04.017
   Miyamoto K, 2007, CELL STEM CELL, V1, P101, DOI 10.1016/j.stem.2007.02.001
   Moeller B, 2006, BRIT J CANCER, V95, P1, DOI 10.1038/sj.bjc.6603201
   Momcilovic O, 2009, STEM CELLS, V27, P1822, DOI 10.1002/stem.123
   Moncalian G, 2004, J MOL BIOL, V335, P937, DOI 10.1016/j.jmb.2003.11.026
   Mordes DA, 2008, CELL CYCLE, V7, P2809, DOI 10.4161/cc.7.18.6689
   Mordes DA, 2008, GENE DEV, V22, P1478, DOI 10.1101/gad.1666208
   Moreno-Herrero F, 2005, NATURE, V437, P440, DOI 10.1038/nature03927
   Murr R, 2006, NAT CELL BIOL, V8, P91, DOI 10.1038/ncb1343
   Myers JS, 2006, J BIOL CHEM, V281, P9346, DOI 10.1074/jbc.M513265200
   O'Sullivan RJ, 2010, NAT REV MOL CELL BIO, V11, P171, DOI 10.1038/nrm2848
   OCONNOR RD, 1980, CLIN IMMUNOL IMMUNOP, V15, P66, DOI 10.1016/0090-1229(80)90021-5
   Olson E, 2007, MOL CELL BIOL, V27, P6053, DOI 10.1128/MCB.00532-07
   PAGANELLI R, 1992, J CLIN IMMUNOL, V12, P84, DOI 10.1007/BF00918137
   Paglin S, 2005, CANCER RES, V65, P11061, DOI 10.1158/0008-5472.CAN-05-1083
   PAINTER RB, 1980, P NATL ACAD SCI-BIOL, V77, P7315, DOI 10.1073/pnas.77.12.7315
   Pandita TK, 2002, ONCOGENE, V21, P611, DOI 10.1038/sj.onc.1205060
   Park JH, 2006, EMBO J, V25, P3986, DOI 10.1038/sj.emboj.7601291
   Paull TT, 1998, MOL CELL, V1, P969, DOI 10.1016/S1097-2765(00)80097-0
   Paull TT, 2005, CELL CYCLE, V4, P737, DOI 10.4161/cc.4.6.1715
   Paulsen RD, 2009, MOL CELL, V35, P228, DOI 10.1016/j.molcel.2009.06.021
   Pellegrini M, 2006, NATURE, V443, P222, DOI 10.1038/nature05112
   Peng G, 2009, NAT CELL BIOL, V11, P865, DOI 10.1038/ncb1895
   Peretz S, 2001, P NATL ACAD SCI USA, V98, P1676, DOI 10.1073/pnas.041416598
   Perlman ZE, 2005, CHEMBIOCHEM, V6, P145, DOI 10.1002/cbic.200400266
   Perry J, 2003, CELL, V112, P151, DOI 10.1016/S0092-8674(03)00033-3
   Pilch DR, 2003, BIOCHEM CELL BIOL, V81, P123, DOI 10.1139/o03-042
   Pirola L, 2001, J BIOL CHEM, V276, P21544, DOI 10.1074/jbc.M011330200
   Poot RA, 2004, NAT CELL BIOL, V6, P1236, DOI 10.1038/ncb1196
   Rai R, 2006, CANCER CELL, V10, P145, DOI 10.1016/j.ccr.2006.07.002
   Rhodes N, 1998, GENE DEV, V12, P3686, DOI 10.1101/gad.12.23.3686
   Richard DJ, 2008, NATURE, V453, P677, DOI 10.1038/nature06883
   Rivera-Calzada A, 2005, STRUCTURE, V13, P243, DOI 10.1016/j.str.2004.12.006
   Robert F, 2006, MOL CELL BIOL, V26, P402, DOI 10.1128/MCB.26.2.402-412.2006
   Roques C, 2009, EMBO J, V28, P2400, DOI 10.1038/emboj.2009.193
   Rossetto D, 2010, CLIN CANCER RES, V16, P4543, DOI 10.1158/1078-0432.CCR-10-0513
   Sampath SC, 2007, MOL CELL, V27, P596, DOI 10.1016/j.molcel.2007.06.026
   Savic V, 2009, MOL CELL, V34, P298, DOI 10.1016/j.molcel.2009.04.012
   SAVITSKY K, 1995, SCIENCE, V268, P1749, DOI 10.1126/science.7792600
   Schmidt DR, 1999, BIOCHEMISTRY-US, V38, P14711, DOI 10.1021/bi991614n
   Schneider JG, 2006, CELL METAB, V4, P377, DOI 10.1016/j.cmet.2006.10.002
   Schrimpf SP, 2005, PROTEOMICS, V5, P2531, DOI 10.1002/pmic.200401198
   Schultz DC, 2002, GENE DEV, V16, P919, DOI 10.1101/gad.973302
   Seidel JJ, 2008, MOL CELL BIOL, V28, P5736, DOI 10.1128/MCB.00326-08
   Shafman T, 1997, NATURE, V387, P520, DOI 10.1038/387520a0
   Shanbhag NM, 2010, CELL, V141, P970, DOI 10.1016/j.cell.2010.04.038
   Shiloh Y, 1997, ANNU REV GENET, V31, P635, DOI 10.1146/annurev.genet.31.1.635
   SHILOH Y, 1982, EXP CELL RES, V140, P191, DOI 10.1016/0014-4827(82)90169-0
   Shiotani B, 2009, MOL CELL, V33, P547, DOI 10.1016/j.molcel.2009.01.024
   Shreeram S, 2006, MOL CELL, V23, P757, DOI 10.1016/j.molcel.2006.07.010
   Sibanda BL, 2010, NATURE, V463, P118, DOI 10.1038/nature08648
   SimbulanRosenthal CM, 1996, BIOCHEMISTRY-US, V35, P11622, DOI 10.1021/bi953010z
   Singh S, 2010, INT J BIOCHEM CELL B, V42, P1105, DOI 10.1016/j.biocel.2010.01.022
   SMITH PJ, 1985, EXP CELL RES, V160, P331, DOI 10.1016/0014-4827(85)90180-6
   So SR, 2009, J CELL BIOL, V187, P977, DOI 10.1083/jcb.200906064
   Soutoglou E, 2008, SCIENCE, V320, P1507, DOI 10.1126/science.ll59051
   Spycher C, 2008, J CELL BIOL, V181, P227, DOI 10.1083/jcb.200709008
   Stewart GS, 1999, CELL, V99, P577, DOI 10.1016/S0092-8674(00)81547-0
   Stiff T, 2006, EMBO J, V25, P5775, DOI 10.1038/sj.emboj.7601446
   Stiff T, 2008, HUM MOL GENET, V17, P3247, DOI 10.1093/hmg/ddn220
   Stilmann M, 2009, MOL CELL, V36, P365, DOI 10.1016/j.molcel.2009.09.032
   Stucki M, 2005, CELL, V123, P1213, DOI 10.1016/j.cell.2005.09.038
   Sun YL, 2007, MOL CELL BIOL, V27, P8502, DOI 10.1128/MCB.01382-07
   Sun YL, 2009, NAT CELL BIOL, V11, P1376, DOI 10.1038/ncb1982
   Sun YL, 2005, P NATL ACAD SCI USA, V102, P13182, DOI 10.1073/pnas.0504211102
   Suzuki A, 2003, J BIOL CHEM, V278, P48, DOI 10.1074/jbc.M206025200
   Takahashi T, 2000, GENES CELLS, V5, P765, DOI 10.1046/j.1365-2443.2000.00365.x
   Takai H, 2007, CELL, V131, P1248, DOI 10.1016/j.cell.2007.10.052
   Takai H, 2010, GENE DEV, V24, P2019, DOI 10.1101/gad.1956410
   Takemura H, 2006, J BIOL CHEM, V281, P30814, DOI 10.1074/jbc.M603747200
   Tian B, 2009, NAT CELL BIOL, V11, P211, DOI 10.1038/ncb1829
   Tobias F, 2010, MUTAT RES-REV MUTAT, V704, P54, DOI 10.1016/j.mrrev.2009.11.004
   Tomimatsu N, 2009, EMBO REP, V10, P629, DOI 10.1038/embor.2009.60
   Tsai WB, 2008, NAT CELL BIOL, V10, P460, DOI 10.1038/ncb1709
   Uziel T, 2003, EMBO J, V22, P5612, DOI 10.1093/emboj/cdg541
   van Attikum H, 2009, TRENDS CELL BIOL, V19, P207, DOI 10.1016/j.tcb.2009.03.001
   van der Linden E, 2009, NUCLEIC ACIDS RES, V37, P1580, DOI 10.1093/nar/gkn1072
   Vaquero A, 2007, NATURE, V450, P440, DOI 10.1038/nature06268
   Venkitaraman AR, 2010, CRIT REV BIOCHEM MOL, V45, P2, DOI 10.3109/10409230903325446
   Verdun RE, 2005, MOL CELL, V20, P551, DOI 10.1016/j.molcel.2005.09.024
   Viniegra JG, 2005, J BIOL CHEM, V280, P4029, DOI 10.1074/jbc.M410344200
   Volonte D, 2009, J BIOL CHEM, V284, P5462, DOI 10.1074/jbc.C800225200
   Waltes R, 2009, AM J HUM GENET, V84, P605, DOI 10.1016/j.ajhg.2009.04.010
   Wang X, 2011, CELL DEATH DIFFER, V18, P5, DOI 10.1038/cdd.2010.106
   Wang Y, 2000, GENE DEV, V14, P927
   Watters D, 1999, J BIOL CHEM, V274, P34277, DOI 10.1074/jbc.274.48.34277
   Wiegman EM, 2007, RADIOTHER ONCOL, V83, P289, DOI 10.1016/j.radonc.2007.05.013
   Williams RS, 2008, CELL, V135, P97, DOI 10.1016/j.cell.2008.08.017
   Williams RS, 2009, CELL, V139, P87, DOI 10.1016/j.cell.2009.07.033
   Wu LM, 2008, P NATL ACAD SCI USA, V105, P11200, DOI 10.1073/pnas.0802885105
   Wu ZH, 2006, SCIENCE, V311, P1141, DOI 10.1126/science.1121513
   Wuerzberger-Davis SM, 2007, ONCOGENE, V26, P641, DOI 10.1038/sj.onc.1209815
   Xiao A, 2009, NATURE, V457, P57, DOI 10.1038/nature07668
   Yajima H, 2006, MOL CELL BIOL, V26, P7520, DOI 10.1128/MCB.00048-06
   Yalcin S, 2008, J BIOL CHEM, V283, P25692, DOI 10.1074/jbc.M800517200
   Yang DQ, 2000, NAT CELL BIOL, V2, P893, DOI 10.1038/35046542
   Yazdi PT, 2002, GENE DEV, V16, P571, DOI 10.1101/gad.970702
   Yoo HY, 2009, MOL BIOL CELL, V20, P2351, DOI 10.1091/mbc.E08-12-1190
   You ZS, 2007, NAT CELL BIOL, V9, P311, DOI 10.1038/ncb1651
   You ZS, 2005, MOL CELL BIOL, V25, P5363, DOI 10.1128/MCB.25.13.5363-5379.2005
   Young DB, 2005, J BIOL CHEM, V280, P27587, DOI 10.1074/jbc.M411689200
   Yuan SSF, 2002, TOXICOLOGY, V177, P123, DOI 10.1016/S0300-483X(02)00220-2
   Yuan Z, 2007, MOL CELL, V27, P149, DOI 10.1016/j.molcel.2007.05.029
   Zhang NX, 2009, EMBO REP, V10, P1029, DOI 10.1038/embor.2009.122
   Zhang ST, 2006, CELL CYCLE, V5, P2787, DOI 10.4161/cc.5.23.3523
   Zhong H, 2005, HUM MOL GENET, V14, P2685, DOI 10.1093/hmg/ddi302
   Zhong ZH, 2007, J BIOL CHEM, V282, P29314, DOI 10.1074/jbc.M701413200
   Zhu XD, 2000, NAT GENET, V25, P347, DOI 10.1038/77139
   Ziv Y, 2006, NAT CELL BIOL, V8, P870, DOI 10.1038/ncb1446
   Zou L, 2003, SCIENCE, V300, P1542, DOI 10.1126/science.1083430
   Zou L, 2007, GENE DEV, V21, P879, DOI 10.1101/gad.1550307
NR 273
TC 89
Z9 101
U1 2
U2 22
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1420-682X
EI 1420-9071
J9 CELL MOL LIFE SCI
JI Cell. Mol. Life Sci.
PD SEP
PY 2011
VL 68
IS 18
BP 2977
EP 3006
DI 10.1007/s00018-011-0683-9
PG 30
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 811ZY
UT WOS:000294258700001
PM 21533982
OA Green Published
DA 2025-06-11
ER

PT J
AU Wang, LZ
   Li, WX
   Li, YG
   Chen, GR
   Zhao, LJ
   Li, W
   Wang, SW
   Wang, CM
   Feng, YX
   Zhang, YB
AF Wang, Lingzhi
   Li, Wenxi
   Li, Yinggang
   Chen, Gengrui
   Zhao, Lijuan
   Li, Wu
   Wang, Shengwei
   Wang, Chunming
   Feng, Yanxian
   Zhang, Yibo
TI Dried tangerine peel polysaccharide (DTPP) alleviates hepatic steatosis
   by suppressing TLR4/MD-2-mediated inflammation and endoplasmic reticulum
   stress
SO BIOORGANIC CHEMISTRY
LA English
DT Article
DE NAFLD; Dried tangerine peel polysaccharide; Inflammation; Endoplasmic
   reticulum stress; Zebrafish
ID RECEPTOR 4; ZEBRAFISH; TLR4; PATHOGENESIS; BINDING; ROLES; CELLS; MD-2;
   LPS
AB Non-alcoholic fatty liver disease (NAFLD) is a complex pathogenic metabolic syndrome characterized by increased inflammation and endoplasmic reticulum stress. In recent years, natural polysaccharides derived from traditional Chinese medicine have shown significant anti-inflammatory effects, making them an attractive therapeutic option. However, little research has been conducted on the therapeutic potential of dried tangerine peel polysaccharide (DTPP) - one of the most important medicinal resources in China. The results of the present study showed that DTPP substantially reduced macrophage infiltration in vivo and suppressed the expression of pro-inflammatory factors and endoplasmic reticulum stress-related genes. Additionally, surface plasmon resonance analysis revealed that DTPP had a specific affinity to myeloid differentiation factor 2, which consequently suppressed lipopolysaccharide-induced inflammation via interaction with the toll-like receptor 4 signaling pathway. This study provides a potential molecular mechanism underlying the anti-inflammatory effects of DTPP on NAFLD and suggests DTPP as a promising therapeutic strategy for NAFLD treatment.
C1 [Wang, Lingzhi; Li, Wenxi; Li, Yinggang; Chen, Gengrui; Zhao, Lijuan; Li, Wu; Wang, Shengwei; Feng, Yanxian] Wuyi Univ, Sch Pharm & Food Engn, Jiangmen 529020, Peoples R China.
   [Wang, Chunming] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa, Macau, Peoples R China.
   [Wang, Lingzhi; Zhang, Yibo] Jinan Univ, Coll Life Sci & Technol, Dept Cell Biol, State Key Lab Bioact Mol & Druggabil Assessment,Na, Guangzhou, Peoples R China.
   [Wang, Lingzhi; Zhang, Yibo] Jinan Univ, Inst Biomed, Coll Life Sci & Technol, State Key Lab Bioact Mol & Druggabil Assessment,Na, Guangzhou, Peoples R China.
C3 Wuyi University; University of Macau; Jinan University; Jinan University
RP Feng, YX (corresponding author), Wuyi Univ, Sch Pharm & Food Engn, Jiangmen 529020, Peoples R China.; Zhang, YB (corresponding author), Jinan Univ, Coll Life Sci & Technol, Dept Cell Biol, State Key Lab Bioact Mol & Druggabil Assessment,Na, Guangzhou, Peoples R China.; Zhang, YB (corresponding author), Jinan Univ, Inst Biomed, Coll Life Sci & Technol, State Key Lab Bioact Mol & Druggabil Assessment,Na, Guangzhou, Peoples R China.
EM yanxianfeng@wyu.edu.cn; zyb_87@hotmail.com
RI Zhao, Lijuan/E-8485-2012; Yanxian, Feng/ABC-1623-2021; Zhang,
   Bob/ABD-5926-2021
FU National Natural Science Foundation of China [32000936, 81902801];
   Guangdong Provincial Key Construction Discipline Research Ability
   Enhancement Project [2022ZDJS026]; Special projects in key areas of
   general colleges and universities in Guangdong Province [2023ZDZX2064];
   Guangdong Basic and Applied Basic Research Foundation [2024A1515030168];
   Wuyi University-Macau University Joint Research Foundation [2022WGALH10,
   2021WGALH13]
FX This work is supported by the National Natural Science Foundation of
   China (No.32000936 and 81902801) , Guangdong Provincial Key Construction
   Discipline Research Ability Enhancement Project (No.2022ZDJS026) , The
   Special projects in key areas of general colleges and universities in
   Guangdong Province (No. 2023ZDZX2064) , Guangdong Basic and Applied
   Basic Research Foundation (No.2024A1515030168) and Wuyi University-Macau
   University Joint Research Foundation (No.2022WGALH10 and 2021WGALH13) .
CR Barreby E, 2022, NAT REV ENDOCRINOL, V18, P461, DOI 10.1038/s41574-022-00675-6
   Buzzetti E, 2016, METABOLISM, V65, P1038, DOI 10.1016/j.metabol.2015.12.012
   Chen B, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00366
   Chen Y, 2016, MOLECULES, V21, DOI 10.3390/molecules21121705
   Davis JM, 2016, INFECT IMMUN, V84, P3047, DOI 10.1128/IAI.00506-16
   de Oliveira S, 2019, J HEPATOL, V70, P710, DOI 10.1016/j.jhep.2018.11.034
   Ghemrawi R, 2018, CELLS-BASEL, V7, DOI 10.3390/cells7060063
   Hou CY, 2020, INT J BIOL MACROMOL, V153, P248, DOI 10.1016/j.ijbiomac.2020.02.315
   Howe K, 2013, NATURE, V496, P498, DOI 10.1038/nature12111
   Hu P, 2006, MOL CELL BIOL, V26, P3071, DOI 10.1128/MCB.26.8.3071-3084.2006
   Hummasti S, 2010, CIRC RES, V107, P579, DOI 10.1161/CIRCRESAHA.110.225698
   Ji Y, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081712
   Jia L, 2018, MOL METAB, V14, P121, DOI 10.1016/j.molmet.2018.05.015
   Khanmohammadi S, 2022, PHARMACOL RES, V185, DOI 10.1016/j.phrs.2022.106507
   Lebeaupin C, 2018, J HEPATOL, V69, P927, DOI 10.1016/j.jhep.2018.06.008
   Loser K, 2010, NAT MED, V16, P713, DOI 10.1038/nm.2150
   Lu YC, 2008, CYTOKINE, V42, P145, DOI 10.1016/j.cyto.2008.01.006
   Nagai Y, 2002, NAT IMMUNOL, V3, P667, DOI 10.1038/ni809
   Paik YH, 2003, HEPATOLOGY, V37, P1043, DOI 10.1053/jhep.2003.50182
   Peng ZC, 2023, FOOD HYDROCOLLOID, V136, DOI 10.1016/j.foodhyd.2022.108237
   Rivera CA, 2007, J HEPATOL, V47, P571, DOI 10.1016/j.jhep.2007.04.019
   Rogero MM, 2018, NUTRIENTS, V10, DOI 10.3390/nu10040432
   Sapp V, 2014, HEPATOLOGY, V60, P1581, DOI 10.1002/hep.27284
   Shao ML, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4528
   Shin HJ, 2007, MOL CELLS, V24, P119
   Spruss A, 2009, HEPATOLOGY, V50, P1094, DOI 10.1002/hep.23122
   Sun SQ, 2019, J ETHNOPHARMACOL, V238, DOI 10.1016/j.jep.2019.111857
   Takashima K, 2009, BRIT J PHARMACOL, V157, P1250, DOI 10.1111/j.1476-5381.2009.00297.x
   Tanaka N, 2019, WORLD J GASTROENTERO, V25, P163, DOI 10.3748/wjg.v25.i2.163
   Vespasiani-Gentilucci U, 2015, LIVER INT, V35, P569, DOI 10.1111/liv.12531
   Vonderlin J, 2023, CELL MOL GASTROENTER, V15, P1311, DOI 10.1016/j.jcmgh.2023.03.002
   Wang YH, 2022, NUTRIENTS, V14, DOI 10.3390/nu14245221
   Xiao J, 2013, NUTR DIABETES, V3, DOI 10.1038/nutd.2013.22
   Xie MT, 2021, INT J BIOL MACROMOL, V185, P917, DOI 10.1016/j.ijbiomac.2021.07.008
   Yu X, 2018, J ETHNOPHARMACOL, V220, P265, DOI 10.1016/j.jep.2018.03.031
   Zhang TS, 2021, J NEUROCHEM, V157, P611, DOI 10.1111/jnc.15302
   Zhang XT, 2022, FOOD FRONTIERS, V3, P785, DOI 10.1002/fft2.169
   Zhang YS, 2022, EUR J MED CHEM, V235, DOI 10.1016/j.ejmech.2022.114291
   Zhang Y, 2022, J ETHNOPHARMACOL, V282, DOI 10.1016/j.jep.2021.114638
NR 39
TC 4
Z9 5
U1 10
U2 32
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0045-2068
EI 1090-2120
J9 BIOORG CHEM
JI Bioorganic Chem.
PD JUN
PY 2024
VL 147
AR 107369
DI 10.1016/j.bioorg.2024.107369
EA APR 2024
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Organic
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA C8D8I
UT WOS:001291628600001
PM 38640721
DA 2025-06-11
ER

PT J
AU Na, MK
   Jeong, YT
   Li, X
   Jin, F
   Hwang, SL
   Kim, GJ
   Yang, JH
   Chang, YC
   Kim, DS
   Kim, CH
   Chang, HW
AF Na, Min Kyun
   Jeong, Yong-Tae
   Li, Xian
   Jin, Fansi
   Hwang, Seung-Lark
   Kim, Geum Jin
   Yang, Ju Hye
   Chang, Young-Chae
   Kim, Dong Soo
   Kim, Cheorl-Ho
   Chang, Hyeun Wook
TI Protective effect of butanol extracts of skin of Anguilla
   japonica against endoplasmic reticulum stress-induced insulin
   resistance via the AMPK pathway in L6 myotubes
SO FOOD SCIENCE AND BIOTECHNOLOGY
LA English
DT Article
DE AMP-activated protein kinase; Anguilla japonica skin; Insulin
   resistance; L6 myotube
ID ACTIVATED PROTEIN-KINASE; METABOLIC SYNDROME; SKELETAL-MUSCLE; MOUSE
   MODEL; GLUCOSE; SENSITIVITY; HOMEOSTASIS; CASCADE; OBESITY; LECTIN
AB The effect of butanol extracts of the skin of Anguilla japonica (BESA) on endoplasmic reticulum (ER) stress-induced insulin resistance in L6 myotubes was investigated. Western blotting revealed that BESA increased phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase, and stimulated glucose uptake in L6 myotubes. Stimulation of AMPK and glucose uptake by BESA were significantly (p < 0.05) reduced by siRNA LKB1 or siRNA AMPK, compared with controls, suggesting that enhanced glucose uptake by BESA was predominantly accomplished via an LKB1-mediated AMPK activation pathway. In addition, BESA effectively reduced phosphorylation of ER stress markers, RNA-activated protein kinase-like ER resident kinase, JNK, and significantly (p < 0.01) increased glucose uptake via AMPK activation in tunicamycin-treated L6 myotubes, compared with controls. Improvement of insulin sensitivity under ER stress conditions by BESA is predominantly accomplished via an LKB1-AMPK-dependent pathway.
C1 [Na, Min Kyun] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea.
   [Jeong, Yong-Tae; Li, Xian; Jin, Fansi; Hwang, Seung-Lark; Kim, Geum Jin; Chang, Hyeun Wook] Yeungnam Univ, Coll Pharm, Gyongsan 712749, Gyeongbuk, South Korea.
   [Yang, Ju Hye] Korea Inst Oriental Med, Korea Med Based Herbal Drug Dev Grp, Taejon 305811, South Korea.
   [Chang, Young-Chae] Catholic Univ Daegu, Sch Med, Dept Pathol, Daegu 705718, South Korea.
   [Kim, Dong Soo] Kyung Sung Univ, Dept Food Sci & Biotechnol, Busan 608736, South Korea.
   [Kim, Cheorl-Ho] Sungkyunkwan Univ, Dept Biol Sci, Suwon 440746, Gyeonggi, South Korea.
C3 Chungnam National University; Yeungnam University; Korea Institute of
   Oriental Medicine (KIOM); Catholic University of Daegu; Sungkyunkwan
   University (SKKU)
RP Chang, HW (corresponding author), Yeungnam Univ, Coll Pharm, Gyongsan 712749, Gyeongbuk, South Korea.
EM hwchang@yu.ac.kr
RI Yang, Ju-Hye/GNH-6607-2022; Kim, Cheorl-Ho/T-6753-2019; na,
   ma/K-4873-2013
OI Na, MinKyun/0000-0002-4865-6506; Kim, Cheorl-Ho/0000-0002-6323-0714
FU Fisheries Technology Development Program - Ministry for Food,
   Agriculture, Forestry, and Fisheries of the Korean government; National
   Research Foundation of Korea - Korean Government (MEST)
   [NRF-2010-0020484]
FX This research was supported by the Fisheries Technology Development
   Program funded by the Ministry for Food, Agriculture, Forestry, and
   Fisheries of the Korean government and, in part, supported by a National
   Research Foundation of Korea Grant funded by the Korean Government
   (MEST) (NRF-2010-0020484).
CR Carling D, 2004, TRENDS BIOCHEM SCI, V29, P18, DOI 10.1016/j.tibs.2003.11.005
   DEFRONZO RA, 1981, DIABETES, V30, P1000, DOI 10.2337/diab.30.12.1000
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Hardie DG, 2003, ENDOCRINOLOGY, V144, P5179, DOI 10.1210/en.2003-0982
   Hawley SA, 2005, CELL METAB, V2, P9, DOI 10.1016/j.cmet.2005.05.009
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Hwang SL, 2013, BRIT J PHARMACOL, V169, P69, DOI 10.1111/bph.12124
   Hwang SL, 2012, BIOCHEM BIOPH RES CO, V418, P402, DOI 10.1016/j.bbrc.2012.01.038
   Jeong YT, 2014, FOOD SCI BIOTECHNOL, V23, P1695, DOI 10.1007/s10068-014-0231-0
   Jeong YT, 2013, MOL PHARMACOL, V84, P147, DOI 10.1124/mol.113.085100
   Kahn BB, 2005, CELL METAB, V1, P15, DOI 10.1016/j.cmet.2004.12.003
   Kemp BE, 2003, BIOCHEM SOC T, V31, P162
   Liang Y, 2011, PROTEIN J, V30, P413, DOI 10.1007/s10930-011-9346-9
   Long YC, 2006, J CLIN INVEST, V116, P1776, DOI 10.1172/JCI29044
   Lu Y, 2013, FOOD CHEM TOXICOL, V57, P307, DOI 10.1016/j.fct.2013.03.029
   Nakatani Y, 2005, J BIOL CHEM, V280, P847, DOI 10.1074/jbc.M411860200
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Ron D, 2002, J CLIN INVEST, V110, P1383, DOI 10.1172/JCI200216784
   Ruderman N, 2004, NAT REV DRUG DISCOV, V3, P340, DOI 10.1038/nrd1344
   Saitoh E, 2005, COMP BIOCHEM PHYS B, V141, P103, DOI 10.1016/j.cbpc.2005.02.002
   Sakamoto K, 2005, EMBO J, V24, P1810, DOI 10.1038/sj.emboj.7600667
   Tasumi S, 2002, J BIOL CHEM, V277, P27305, DOI 10.1074/jbc.M202648200
   Xue BZ, 2006, J PHYSIOL-LONDON, V574, P73, DOI 10.1113/jphysiol.2006.113217
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI13505
NR 25
TC 0
Z9 0
U1 0
U2 10
PU KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
PI SEOUL
PA #605, KOREA SCI TECHNOL CENT, 635-4 YEOKSAM-DONG, KANGNAM-GU, SEOUL,
   135-703, SOUTH KOREA
SN 1226-7708
EI 2092-6456
J9 FOOD SCI BIOTECHNOL
JI Food Sci. Biotechnol.
PD JUN
PY 2015
VL 24
IS 3
BP 1069
EP 1075
DI 10.1007/s10068-015-0137-5
PG 7
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA CI6QR
UT WOS:000354886300037
DA 2025-06-11
ER

PT J
AU Kwon, AR
   Yoon, YS
   Min, KP
   Lee, YK
   Jeon, JH
AF Kwon, A. Rom
   Yoon, Yeong Sook
   Min, Kyong Pil
   Lee, Yoon Kyung
   Jeon, Ji Ho
TI Eating alone and metabolic syndrome: A population-based Korean National
   Health and Nutrition Examination Survey 2013-2014
SO OBESITY RESEARCH & CLINICAL PRACTICE
LA English
DT Article
DE Eating alone; Commensality; Living alone; Abdominal obesity; Metabolic
   syndrome
ID SCIENTIFIC STATEMENT; PHYSICAL-ACTIVITY; ASSOCIATION; OBESITY; ADULTS;
   FOOD; BEHAVIORS; QUESTIONNAIRE; DEPRESSION; VALIDITY
AB Eating alone has been an emerging social concern in modern life. However, there is little research on the association between eating alone and Metabolic syndrome (MetS).
   We aimed to assess the association between eating alone and the MetS and to identify whether sociodemographic factors modify this association.
   This study included 7725 adults (>= 19 years} who participated in the Korean National Health and Nutrition Examination Survey (KNHANES) 2013-2014. Multivariable logistic regression analysis was used for assessing the association of eating alone (none, 1 time/day, and >= 2 times/day) with MetS.
   The percentages of subjects with MetS were 30.4% in men and 24.2% in women. 20.8% of men and 29.2% of women ate alone >= 2 times/day. Individuals who ate alone 2 or more times per day showed higher frequency of living alone, having no spouse, skip meals, and less eating out (p < 0.05). Women with eating alone >= 2 times/day had a crude OR of 1.29 (95% Cl:1.08-1.53, p-trend = 0.001) for MetS compared with women without eating alone. However, this association was no longer significant after adjustments for confounding factors. Eating alone >= 2 times/day was significantly associated with increase abdominal obesity (OR, 95% Cl: 1.45, 1.10-1.91, p-trend = 0.039) and MetS (1.64, 1.28-2.10, p-trend-0.004) in men. Eating alone was associated with a higher likelihood of having a MetS in men without spouse as compared with those with spouse (OR for men without spouse 3.02, 95% CI: 1.50-6.11 and OR for men with spouse 1.48, 95% CI: 1.22-1.7, p-interaction = 0.027).
   Our results indicate that eating alone may be a potential risk factor for MetS. (C) 2017 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
C1 [Kwon, A. Rom; Lee, Yoon Kyung; Jeon, Ji Ho] Dongguk Univ, Smart Healthcare Ctr, Ilsan Hosp, 27 Dongguk Ro, Goyang Si 10326, Gyeonggi Do, South Korea.
   [Yoon, Yeong Sook] Inje Univ, Dept Family Med, Ilsan Paik Hosp, 170 Juhwa Ro, Goyang Si 10380, Gyeonggi Do, South Korea.
   [Min, Kyong Pil] HurayPositive Inc, 69,Nonhyeon Ro 149 Gil, Seoul 06039, South Korea.
C3 Dongguk University; NHIS Ilsan Hospital; Inje University
RP Yoon, YS (corresponding author), Inje Univ, Dept Family Med, Ilsan Paik Hosp, 170 Juhwa Ro, Goyang Si 10380, Gyeonggi Do, South Korea.
EM sweet6531@naver.com; ysyoon@paik.ac.kr; kpmin@huray.net;
   lorain0331@nate.com; jihojeon744@naver.com
OI Yoon, Yeong Sook/0000-0002-9249-2940
FU Residential Environment Research Program - Ministry of Land,
   Infrastructure and Transport of Korean government [17RERP-B090228-04]
FX This research was supported by a grant (17RERP-B090228-04) from
   Residential Environment Research Program funded by Ministry of Land,
   Infrastructure and Transport of Korean government.
CR Allaert FA, 2015, VALUE HEALTH, V18, pA711, DOI 10.1016/j.jval.2015.09.2679
   [Anonymous], 2015, STAT KOREA POPULATIO
   Calton EK, 2014, NUTR RES, V34, P559, DOI 10.1016/j.nutres.2014.06.012
   Choi Mi-Kyeong, 2016, [Korean Journal of community Nutrition, 대한지역사회영양학회지], V21, P256
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hanna KL, 2015, NUTR REV, V73, P594, DOI 10.1093/nutrit/nuv024
   He D, 2014, ENDOCRINE, V46, P231, DOI 10.1007/s12020-013-0110-0
   Hetherington MM, 2006, PHYSIOL BEHAV, V88, P498, DOI 10.1016/j.physbeh.2006.04.025
   Holm L, 2016, APPETITE, V103, P358, DOI 10.1016/j.appet.2016.04.034
   Katsarou A, 2014, EUR J CLIN NUTR, V68, P1016, DOI 10.1038/ejcn.2014.74
   Kimura Y, 2012, J NUTR HEALTH AGING, V16, P728, DOI 10.1007/s12603-012-0067-3
   Korea Centers for Disease Control and Prevention, 2014, AN GUID 5 KOR NAT HL
   Kuroda A, 2015, J AM MED DIR ASSOC, V16, P578, DOI 10.1016/j.jamda.2015.01.078
   Kutsuma A, 2014, SCIENTIFICA, V2014, DOI 10.1155/2014/253581
   Lee SA, 2016, INT J SOC PSYCHIATR, V62, P560, DOI 10.1177/0020764016654505
   Lee SY, 2007, DIABETES RES CLIN PR, V75, P72, DOI 10.1016/j.diabres.2006.04.013
   Lee YC, 2015, MULT SCLER J, V21, P57
   Lee YeonJoo Lee YeonJoo, 2015, Journal of Nutrition and Health, V48, P277
   Mekhmoukh A, APPETITE
   Nakajima K, 2015, J DIABETES METAB DIS, V14, DOI 10.1186/s40200-015-0147-0
   Oh Sein, 2014, [The Korean Journal of Food and Nutrition, 한국식품영양학회지], V27, P940
   Oh SW, 2005, DIABETES CARE, V28, P2064, DOI 10.2337/diacare.28.8.2064
   Reaven GM, 2005, CLIN CHEM, V51, P931, DOI 10.1373/clinchem.2005.048611
   Salvy SJ, 2009, AM J CLIN NUTR, V90, P282, DOI 10.3945/ajcn.2009.27658
   Scherwitz L, 2005, EXPLORE-NY, V1, P342, DOI 10.1016/j.explore.2005.06.004
   Sobal J, 2002, SOCIOL REV, V50, P378, DOI 10.1111/1467-954X.00388
   St-Onge MP, 2017, CIRCULATION, V135, pE96, DOI 10.1161/CIR.0000000000000476
   Tani Y, 2015, APPETITE, V95, P1, DOI 10.1016/j.appet.2015.06.005
   Tanofsky-Kraff M, 2007, J CONSULT CLIN PSYCH, V75, P901, DOI 10.1037/0022-006X.75.6.901
   Vazquez IA, 2007, ENDOCRINOL NUTR, V54, P530
   Vesnaver E, 2015, PSYCHOL SCI SOC SCI, V71, P1059
   Wang XY, 2016, BMC GERIATR, V16, DOI 10.1186/s12877-016-0197-2
   Yeung WJJ, 2015, DEMOGR RES, V32, P1099, DOI 10.4054/DemRes.2015.32.40
   Yiengprugsawan Vasoontara, 2015, Glob J Health Sci, V7, P270, DOI 10.5539/gjhs.v7n4p270
   Yoon YS, 2013, EUR J CLIN NUTR, V67, P141, DOI 10.1038/ejcn.2012.204
   Yoon YS, 2004, AM J CLIN NUTR, V80, P217
NR 37
TC 34
Z9 36
U1 0
U2 7
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-403X
EI 1878-0318
J9 OBES RES CLIN PRACT
JI Obes. Res. Clin. Pract.
PD MAR-APR
PY 2018
VL 12
IS 2
BP 146
EP 157
DI 10.1016/j.orcp.2017.09.002
PG 12
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA GG1LJ
UT WOS:000432448200003
PM 29066025
DA 2025-06-11
ER

PT J
AU Decorde, K
   Teissedre, PL
   Sutra, T
   Ventura, E
   Cristol, JP
   Rouanet, JM
AF Decorde, Kelly
   Teissedre, Pierre-Louis
   Sutra, Thibault
   Ventura, Emilie
   Cristol, Jean-Paul
   Rouanet, Jean-Max
TI Chardonnay grape seed procyanidins prevent obesity in hamsters
SO AGRO FOOD INDUSTRY HI-TECH
LA English
DT Article
DE obesity; adipocytokines; oxidative stress; grape seed proanthocyanidins;
   hamsters
ID SYSTEMIC OXIDATIVE STRESS; DIET-INDUCED OBESITY; FAT ACCUMULATION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; GLUCOSE LEVEL; OXIDASE; RODENTS;
   MICE; ABSORPTION
AB We analyzed the effects of a phenolic grape seed extract (GSE) on obesity and oxidative stress in hamsters receiving a high-fat diet (HF). Hamsters received a HF diet plus a daily gavage with water (Control, HF) or a solution of GSE (HF+GSE), for 12 weeks. HF diet increased abdominal fat. GSE avoided this feature. HF diet led to higher plasma glucose, triglycerides, insulin and insulin resistance values. GSE prevented in part these effects, reducing insulinemia and leptinemia by 16.5 percent an 45 percent respectively, whereas adiponectin level increased by 61 percent compared with obese controls. GSE lowered glycemic and insulin resistance and strongly prevented cardiac NAD(P)H oxidase activity (74 percent) and expression (30 percent). For the first time the chronic consumption of grape seed tannins has potential effects against the development of obesity.
C1 [Decorde, Kelly; Sutra, Thibault; Ventura, Emilie; Cristol, Jean-Paul; Rouanet, Jean-Max] Univ Montpellier Sud France, UMR Prevent Malnutr & Pathol Associees 204, Montpellier, France.
   [Teissedre, Pierre-Louis] Univ Bordeaux 2, INRA, Fac Oenol, UMR Oenol 1219, Talence, France.
C3 Institut de Recherche pour le Developpement (IRD); Universite de
   Montpellier; INRAE; Universite de Bordeaux
RP Rouanet, JM (corresponding author), Univ Montpellier Sud France, UMR Prevent Malnutr & Pathol Associees 204, Montpellier, France.
RI Teissedre, Pierre-Louis/I-6885-2016
OI TEISSEDRE, Pierre-Louis/0000-0002-0115-5456
CR Al-Awwadi NA, 2005, J AGR FOOD CHEM, V53, P151, DOI 10.1021/jf048919f
   Auger C, 2005, J AGR FOOD CHEM, V53, P2015, DOI 10.1021/jf048177q
   BAYNES JW, 1991, DIABETES, V40, P405, DOI 10.2337/diabetes.40.4.405
   Cho SY, 2007, AM J PHYSIOL-ENDOC M, V292, pE1166, DOI 10.1152/ajpendo.00436.2006
   Decorde K, 2008, MOL NUTR FOOD RES, V52, P400, DOI 10.1002/mnfr.200700141
   Esposito K, 2003, JAMA-J AM MED ASSOC, V289, P1799, DOI 10.1001/jama.289.14.1799
   Fortuño A, 2006, DIABETES, V55, P209, DOI 10.2337/diabetes.55.1.209
   Fujita K, 2006, CIRC J, V70, P1437, DOI 10.1253/circj.70.1437
   Inoguchi T, 2000, DIABETES, V49, P1939, DOI 10.2337/diabetes.49.11.1939
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Klaus S, 2005, INT J OBESITY, V29, P615, DOI 10.1038/sj.ijo.0802926
   Maggi-Capeyron MF, 2002, J NUTR BIOCHEM, V13, P296, DOI 10.1016/S0955-2863(01)00222-4
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mokdad AH, 2003, JAMA-J AM MED ASSOC, V289, P76, DOI 10.1001/jama.289.1.76
   Murase T, 2002, INT J OBESITY, V26, P1459, DOI 10.1038/sj.ijo.0802141
   Nagao T, 2007, OBESITY, V15, P1473, DOI 10.1038/oby.2007.176
   Nakagawa K, 2004, BIOL PHARM BULL, V27, P1775, DOI 10.1248/bpb.27.1775
   Ohashi K, 2007, ARTERIOSCL THROM VAS, V27, P1910, DOI 10.1161/ATVBAHA.107.147645
   Pajvani Utpal B, 2003, Curr Diab Rep, V3, P207, DOI 10.1007/s11892-003-0065-2
   REEVES PG, 1993, J NUTR, V123, P1939, DOI 10.1093/jn/123.11.1939
   Saito M, 2005, FOOD CHEM TOXICOL, V43, P411, DOI 10.1016/j.fct.2004.11.008
   Sugiyama H, 2007, J AGR FOOD CHEM, V55, P4604, DOI 10.1021/jf070569k
   Tao L, 2007, CIRCULATION, V115, P1408, DOI 10.1161/CIRCULATIONAHA.106.666941
   Wolfram S, 2005, ANN NUTR METAB, V49, P54, DOI 10.1159/000084178
   Yaspelkis BB, 2004, LIFE SCI, V74, P1801, DOI 10.1016/j.lfs.2003.08.037
NR 25
TC 1
Z9 3
U1 0
U2 8
PU TEKNOSCIENZE PUBL
PI MILANO
PA VIALE BRIANZA 22, 20127 MILANO, ITALY
SN 1722-6996
EI 2035-4606
J9 AGRO FOOD IND HI TEC
JI Agro Food Ind. Hi-Tech
PD NOV-DEC
PY 2009
VL 20
IS 6
BP 22
EP 24
PG 3
WC Biotechnology & Applied Microbiology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Food Science & Technology
GA 548PG
UT WOS:000273978100005
DA 2025-06-11
ER

PT J
AU Wang, JW
   Wan, XY
   Zhu, HT
   Lu, C
   Yu, WL
   Yu, CH
   Shen, Z
   Li, YM
AF Wang, Jie-wei
   Wan, Xing-yong
   Zhu, Hua-tuo
   Lu, Chao
   Yu, Wei-lai
   Yu, Chao-hui
   Shen, Zhe
   Li, You-ming
TI Lipotoxic Effect of p21 on Free Fatty Acid-Induced Steatosis in L02
   Cells
SO PLOS ONE
LA English
DT Article
ID LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; PROTEASOME INHIBITOR;
   OXIDATIVE STRESS; PROGRESSION; MICE; SENESCENCE; REGENERATION;
   PATHOGENESIS; HEPATOCYTES
AB Nonalcoholic fatty liver disease (NAFLD) is increasingly regarded as a hepatic manifestation of metabolic syndrome. Though with high prevalence, the mechanism is poorly understood. This study aimed to investigate the effects of p21 on free fatty acid (FFA)-induced steatosis in L02 cells. We therefore analyzed the L02 cells with MG132 and siRNA treatment for different expression of p21 related to lipid accumulation and lipotoxicity. Cellular total lipid was stained by Oil Red O, while triglyceride content, cytotoxicity assays, lipid peroxidation markers and anti-oxidation levels were measured by enzymatic kits. Treatment with 1 mM FFA for 48 hr induced magnificent intracellular lipid accumulation and increased oxidative stress in p21 overload L02 cells compared to that in p21 knockdown L02 cells. By increasing oxidative stress and peroxidation, p21 accelerates FFA-induced lipotoxic effect in L02 cells and might provide information about potentially new targets for drug development and treatments of NAFLD.
C1 [Wang, Jie-wei; Wan, Xing-yong; Zhu, Hua-tuo; Lu, Chao; Yu, Wei-lai; Yu, Chao-hui; Shen, Zhe; Li, You-ming] Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Gastroenterol, Hangzhou 310003, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Li, YM (corresponding author), Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Gastroenterol, Hangzhou 310003, Zhejiang, Peoples R China.
EM zlym@zju.edu.cn
OI Ma, Han/0000-0001-9985-3035
FU National Natural Science Foundation of China [81270487, 81300303]
FX National Natural Science Foundation of China Grant number: 81270487,
   81300303 (http://www.nsfc.gov.cn/publish/portal0/default.htm). The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
CR Alexandrova A, 2008, CELL BIOCHEM FUNCT, V26, P392, DOI 10.1002/cbf.1459
   Aravinthan A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0072904
   Aravinthan A, 2013, J HEPATOL, V58, P549, DOI 10.1016/j.jhep.2012.10.031
   Araya J, 2004, CLIN SCI, V106, P635, DOI 10.1042/CS20030326
   Bogyo M, 1997, P NATL ACAD SCI USA, V94, P6629, DOI 10.1073/pnas.94.13.6629
   Chalasani N, 2012, HEPATOLOGY, V55, P2005, DOI 10.1002/hep.25762
   Chu JH, 2011, WORLD J GASTROENTERO, V17, P2379, DOI 10.3748/wjg.v17.i19.2379
   Cortez-Pinto H, 1999, GASTROENTEROLOGY, V116, P1184, DOI 10.1016/S0016-5085(99)70022-3
   Day CP, 2002, BEST PRACT RES CL GA, V16, P663, DOI 10.1053/bega.2002.0333
   ELDEIRY WS, 1993, CELL, V75, P817, DOI 10.1016/0092-8674(93)90500-P
   Gartel AL, 2005, CANCER RES, V65, P3980, DOI 10.1158/0008-5472.CAN-04-3995
   Gómez-Lechón MJ, 2007, CHEM-BIOL INTERACT, V165, P106, DOI 10.1016/j.cbi.2006.11.004
   Guo N, 2013, ASIA-PAC J CLIN ONCO, V9, P6, DOI 10.1111/j.1743-7563.2012.01535.x
   Kim CH, 2008, CLEV CLIN J MED, V75, P721, DOI 10.3949/ccjm.75.10.721
   Leclercq IA, 2000, J CLIN INVEST, V105, P1067, DOI 10.1172/JCI8814
   Letteron P, 1996, J HEPATOL, V24, P200, DOI 10.1016/S0168-8278(96)80030-4
   Marra F, 2008, TRENDS MOL MED, V14, P72, DOI 10.1016/j.molmed.2007.12.003
   Masgras I, 2012, J BIOL CHEM, V287, P9845, DOI 10.1074/jbc.M111.250357
   Mehta K, 2002, NUTR REV, V60, P289, DOI 10.1301/002966402320387224
   Nakajima T, 2010, PATHOL INT, V60, P175, DOI 10.1111/j.1440-1827.2009.02504.x
   Parekh S, 2007, GASTROENTEROLOGY, V132, P2191, DOI 10.1053/j.gastro.2007.03.055
   Passos JF, 2010, MOL SYST BIOL, V6, DOI 10.1038/msb.2010.5
   Richardson MM, 2007, GASTROENTEROLOGY, V133, P80, DOI 10.1053/j.gastro.2007.05.012
   Rodriguez R, 2006, MOL BIOL CELL, V17, P402, DOI 10.1091/mbc.E05-07-0594
   Roskams T, 2003, AM J PATHOL, V163, P1301, DOI 10.1016/S0002-9440(10)63489-X
   Seki S, 2005, HEPATOL RES, V33, P132, DOI 10.1016/j.hepres.2005.09.020
   Sherr CJ, 1999, GENE DEV, V13, P1501, DOI 10.1101/gad.13.12.1501
   Tomita K, 2012, J HEPATOL, V57, P837, DOI 10.1016/j.jhep.2012.05.013
   Torbenson M, 2002, AM J PATHOL, V161, P155, DOI 10.1016/S0002-9440(10)64167-3
   Vernon G, 2011, ALIMENT PHARM THER, V34, P274, DOI 10.1111/j.1365-2036.2011.04724.x
   Wu XD, 2008, HEPATOLOGY, V47, P1905, DOI 10.1002/hep.22239
   Yang SQ, 2004, HEPATOLOGY, V39, P403, DOI 10.1002/hep.20082
   Zhang X, 2011, AM J PHYSIOL-GASTR L, V302, P558
NR 33
TC 4
Z9 5
U1 0
U2 17
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 30
PY 2014
VL 9
IS 4
AR e96124
DI 10.1371/journal.pone.0096124
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AL1WP
UT WOS:000338917300027
PM 24788149
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Craft, S
   Foster, TC
   Landfield, PW
   Maier, SF
   Resnick, SM
   Yaffe, K
AF Craft, Suzanne
   Foster, Thomas C.
   Landfield, Philip W.
   Maier, Steven F.
   Resnick, Susan M.
   Yaffe, Kristine
TI Session III: Mechanisms of Age-Related Cognitive Change and Targets for
   Intervention: Inflammatory, Oxidative, and Metabolic Processes
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
DE Aging; Cognition; Inflammation; Oxidative stress; Metabolism
ID ALZHEIMER-DISEASE; IMPAIRMENT; DECLINE; MEMORY; RISK; HIPPOCAMPUS;
   PREVALENCE; DEMENTIA; LATINOS; PROTEIN
AB There is increasing evidence from basic science and human epidemiological studies that inflammation, oxidative stress, and metabolic abnormalities are associated with age-related cognitive decline and impairment. This article summarizes selected research on these topics presented at the Cognitive Aging Summit II. Speakers in this session presented evidence highlighting the roles of these processes and pathways on age-related cognitive decline, pointing to possible targets for intervention in nondemented older adults. Specific areas discussed included age differences in the production of cytokines following injury or infection, mechanisms underlying oxidative stress-induced changes in memory consolidation, insulin effects on brain signaling and memory, and the association between metabolic syndrome and cognitive decline in older adults. These presentations emphasize advances in our understanding of mechanisms and modifiers of age-related cognitive decline and provide insights into potential targets to promote cognitive health in older adults.
C1 [Resnick, Susan M.] NIA, Lab Behav Neurosci, BRC, Baltimore, MD 21224 USA.
   [Craft, Suzanne] Univ Washington, Dept Psychiat & Behav Sci, Geriatr Res Educ & Clin Ctr, Seattle, WA 98195 USA.
   [Foster, Thomas C.] Univ Florida, Dept Neurosci, Evelyn F & William L McKnight Brain Inst, Gainesville, FL 32610 USA.
   [Landfield, Philip W.] Univ Kentucky, Dept Mol & Biomed Pharmacol, Coll Med, Lexington, KY 40506 USA.
   [Maier, Steven F.] Univ Colorado, Dept Psychol, Boulder, CO 80309 USA.
   [Maier, Steven F.] Univ Colorado, Dept Neurosci, Boulder, CO 80309 USA.
   [Yaffe, Kristine] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA.
   [Yaffe, Kristine] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA.
   [Yaffe, Kristine] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
   [Yaffe, Kristine] San Francisco VA Med Ctr, San Francisco, CA USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); Geriatric Research Education & Clinical Center; University
   of Washington; University of Washington Seattle; State University System
   of Florida; University of Florida; University of Kentucky; University of
   Colorado System; University of Colorado Boulder; University of Colorado
   System; University of Colorado Boulder; University of California System;
   University of California San Francisco; University of California System;
   University of California San Francisco; University of California System;
   University of California San Francisco; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); San Francisco VA Medical
   Center
RP Resnick, SM (corresponding author), NIA, Lab Behav Neurosci, BRC, Room 4B335,251 Bayview Blvd, Baltimore, MD 21224 USA.
EM susan.resnick@nih.gov
RI Yaffe, Kristine/LLL-8209-2024
FU NCATS NIH HHS [UL1 TR000064] Funding Source: Medline; NIA NIH HHS [R37
   AG036800, R01 AG014979, R01 AG034605, P30 AG028740] Funding Source:
   Medline; Intramural NIH HHS [ZIA AG000191] Funding Source: Medline
CR [Anonymous], JAMA
   Barbieri M, 2003, AM J PHYSIOL-ENDOC M, V285, pE1064, DOI 10.1152/ajpendo.00296.2003
   Bayer-Carter JL, 2011, ARCH NEUROL-CHICAGO, V68, P743, DOI 10.1001/archneurol.2011.125
   Blalock EM, 2003, J NEUROSCI, V23, P3807
   Blalock EM, 2010, J NEUROSCI, V30, P6058, DOI 10.1523/JNEUROSCI.3956-09.2010
   Bodhinathan K, 2010, J NEUROPHYSIOL, V104, P2586, DOI 10.1152/jn.00577.2010
   Bodhinathan K, 2010, J NEUROSCI, V30, P1914, DOI 10.1523/JNEUROSCI.5485-09.2010
   Bourdel-Marchasson I, 2010, DIABETES METAB, V36, P173, DOI 10.1016/j.diabet.2010.03.001
   Buckner RL, 2004, NEURON, V44, P195, DOI 10.1016/j.neuron.2004.09.006
   *CENS US, 2000, NAT POP PROJ
   Craft S, 2009, ARCH NEUROL-CHICAGO, V66, P300, DOI 10.1001/archneurol.2009.27
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Foster TC, 2007, AGING CELL, V6, P319, DOI 10.1111/j.1474-9726.2007.00283.x
   Gu YA, 2010, ARCH NEUROL-CHICAGO, V67, P699, DOI 10.1001/archneurol.2010.84
   Haan MN, 2003, J AM GERIATR SOC, V51, P169, DOI 10.1046/j.1532-5415.2003.51054.x
   Jackson TC, 2010, J NEUROCHEM, V115, P941, DOI 10.1111/j.1471-4159.2010.06984.x
   Kadish I, 2009, J NEUROSCI, V30, P6058
   Lee I, 2002, NAT NEUROSCI, V5, P162, DOI 10.1038/nn790
   Nelson TJ, 2008, EUR J PHARMACOL, V585, P76, DOI 10.1016/j.ejphar.2008.01.051
   Papadia S, 2008, NAT NEUROSCI, V11, P476, DOI 10.1038/nn2071
   Ridker PM, 2004, CIRCULATION, V109, P2818, DOI 10.1161/01.CIR.0000132467.45278.59
   Yaffe K, 2004, JAMA-J AM MED ASSOC, V292, P2237, DOI 10.1001/jama.292.18.2237
   Yaffe K, 2007, J AM GERIATR SOC, V55, P758, DOI 10.1111/j.1532-5415.2007.01139.x
   Yaffe K, 2009, ARCH NEUROL-CHICAGO, V66, P324, DOI 10.1001/archneurol.2008.566
   Zeier Z, 2011, MECH AGEING DEV, V132, P8, DOI 10.1016/j.mad.2010.10.006
   Zhao WQ, 2009, BBA-MOL BASIS DIS, V1792, P482, DOI 10.1016/j.bbadis.2008.10.014
NR 26
TC 49
Z9 52
U1 0
U2 14
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD JUL
PY 2012
VL 67
IS 7
BP 754
EP 759
DI 10.1093/gerona/gls112
PG 6
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 970PD
UT WOS:000306143700008
PM 22570133
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Kim, IG
   So, WY
   Sung, DJ
AF Kim, Ill-Gwang
   So, Wi-Young
   Sung, Dong Jun
TI The relationships between lifestyle factors and hypertension in
   community-dwelling Korean adults
SO JOURNAL OF PHYSICAL THERAPY SCIENCE
LA English
DT Article
DE Hypertension; Lifestyle factors
ID BLOOD-PRESSURE; ARTERIAL-HYPERTENSION; METABOLIC SYNDROME; POPULATION;
   PREVENTION; PREVALENCE; STRESS; WOMEN; RACE; MEN
AB [Purpose] This study was performed to determine whether certain lifestyle factors are associated with hypertension in community-dwelling Korean adults. [Subjects and Methods] The subjects were 586 males and 1,135 females >20 years old who had visited a public health promotion center in Seoul, Republic of Korea to take a survey related to lifestyle factors. Hypertension status was defined according to the criteria of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure VII report. [Results] The relationships between lifestyle factors and hypertension status were assessed using multivariate logistic regression analysis after adjusting for age and gender. Only mental stress and economic status significantly predicted hypertension status. [Conclusion] We conclude that sleep duration, education level, frequency of drinking and smoking status were not associated with hypertension status. However, economic status and mental stress were significantly associated with hypertension in community-dwelling Korean adults, regardless of age or gender.
C1 [Kim, Ill-Gwang] Seowon Univ, Sch Human Serv, Dept Leisure Sport, Cheongju, South Korea.
   [So, Wi-Young] Korea Natl Univ Transportat, Coll Human & Arts, Sports & Hlth Care Major, Seoul, South Korea.
   [Sung, Dong Jun] Konkuk Univ, Coll Sci & Technol, Div Sport Sci, 268 Chungwon Daero, Chungju Si 380701, Chungcheongbuk, South Korea.
C3 Seowon University; Korea National University of Transportation; Konkuk
   University
RP Sung, DJ (corresponding author), Konkuk Univ, Coll Sci & Technol, Div Sport Sci, 268 Chungwon Daero, Chungju Si 380701, Chungcheongbuk, South Korea.
EM sls98@kku.ac.kr
OI So, Wi-Young/0000-0002-9322-5852
CR Bae JM, 2002, J KOREAN MED SCI, V17, P328, DOI 10.3346/jkms.2002.17.3.328
   Davis MM, 2002, SEMIN NEPHROL, V22, P35, DOI 10.1053/snep.2002.28642
   de Morais PK, 2015, J PHYS THER SCI, V27, P51, DOI 10.1589/jpts.27.51
   Dickey R A, 2001, Endocr Pract, V7, P392
   Esler M, 2008, CLIN EXP PHARMACOL P, V35, P498, DOI 10.1111/j.1440-1681.2008.04904.x
   Gabler NB, 2012, CHEST, V141, P20, DOI 10.1378/chest.11-0404
   Ham OK, 2011, ASIA-PAC J PUBLIC HE, V23, P485, DOI 10.1177/1010539509347941
   Hur S, 2014, J PHYS THER SCI, V26, P1367, DOI 10.1589/jpts.26.1367
   Lynn S.Bickley, 2013, BATES GUIDE PHYS EXA
   Lyra R, 2012, REV ASSOC MED BRAS, V58, P209, DOI 10.1590/S0104-42302012000200017
   McGrane MM, 2011, CURR CARDIOVASC RISK, V5, P287, DOI 10.1007/s12170-011-0181-5
   National High Blood Pressure Education Program, 2003, JNC7 NAT HIGH BLOOD
   Slama M, 2002, CURR OPIN CARDIOL, V17, P531, DOI 10.1097/00001573-200209000-00014
   Sull JW, 2010, STROKE, V41, P2157, DOI 10.1161/STROKEAHA.110.586347
   Svetkey LP, 2005, J HUM HYPERTENS, V19, P21, DOI 10.1038/sj.jhh.1001770
   Talukder MAH, 2011, AM J PHYSIOL-HEART C, V300, pH388, DOI 10.1152/ajpheart.00868.2010
   Weir M.R., 2005, HYPERTENSION
   Wu MC, 2012, PREV MED, V55, P305, DOI 10.1016/j.ypmed.2012.07.013
NR 18
TC 7
Z9 8
U1 0
U2 2
PU SOC PHYSICAL THERAPY SCIENCE
PI TOKYO
PA C/O PUBLICATION CENTER, 1-24-12 SUGAMO, TOSHIMA-KU, TOKYO, 170-0002,
   JAPAN
SN 0915-5287
EI 2187-5626
J9 J PHYS THER SCI
JI J. Phys. Ther. Sci.
PD DEC
PY 2015
VL 27
IS 12
BP 3689
EP 3692
DI 10.1589/jpts.27.3689
PG 4
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rehabilitation
GA DB6EF
UT WOS:000368605500018
PM 26834333
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Changchien, TC
   Yen, YC
   Lin, CL
   Lin, MC
   Liang, JA
   Kao, CH
AF Changchien, Te-Chang
   Yen, Yung-Chieh
   Lin, Cheng-Li
   Lin, Ming-Chia
   Liang, Ji-An
   Kao, Chia-Hung
TI High Risk of Depressive Disorders in Patients With Gout A Nationwide
   Population-Based Cohort Study
SO MEDICINE
LA English
DT Article
ID MAGNETIC-RESONANCE-SPECTROSCOPY; METABOLIC SYNDROME; BIPOLAR DISORDER;
   CONTROLLED-TRIAL; MOOD DISORDERS; DOUBLE-BLIND; MANIA; SCHIZOPHRENIA;
   ALLOPURINOL; PLACEBO
AB Metabolic abnormalities are common in patients with depressive disorders. However, the relationship between gout and depression is unclear. We explored the causal relationship among gout, antigout medication, and the associated risk of incidental depressive disorders.
   In this nationwide cohort study, we sampled data from the National Health Insurance Research Database to recruit 34,050 patients with gout as the gout cohort and 68,100 controls (without gout) as the nongout cohort. Our primary endpoint was the diagnosis of depressive disorders during follow-up. The overall study population was followed up until depression diagnosis, withdrawal from the NHI program, or the end of the study. The differences in demographic and clinical characteristics between both cohorts were determined using the Chi-square test for categorical variables and the t-test for continuous variables. Cox proportional hazard regression models were used to examine the effect of gout on the risk of depression, represented using the hazard ratio with the 95% confidence interval.
   Patients with gout exhibited a higher risk of depressive disorders than controls did. The risk of depressive disorders increased with age and was higher in female patients and those with hypertension, stroke, and coronary artery disease. Nonsteroidal antiinflammatory drug and prednisolone use was associated with a reduced risk of depression. Patients with gout who had received antigout medication exhibited a reduced risk of depressive disorders compared with nongout patients.
   Our findings support that gout increases the risk of depressive disorders, and that antigout medication use reduces the risk.
C1 [Changchien, Te-Chang; Yen, Yung-Chieh] E Da Hosp, Dept Psychiat, Kaohsiung, Taiwan.
   [Changchien, Te-Chang; Yen, Yung-Chieh] I Shou Univ, Sch Med, Kaohsiung, Taiwan.
   [Lin, Cheng-Li] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan.
   [Lin, Cheng-Li] China Med Univ, Coll Med, Taichung 40447, Taiwan.
   [Lin, Ming-Chia] I Shou Univ, Dept Nucl Med, Kaohsiung, Taiwan.
   [Liang, Ji-An; Kao, Chia-Hung] China Med Univ, Grad Inst Clin Med Sci, Coll Med, Taichung 40447, Taiwan.
   [Liang, Ji-An; Kao, Chia-Hung] China Med Univ, Sch Med, Coll Med, Taichung 40447, Taiwan.
   [Liang, Ji-An] China Med Univ Hosp, Dept Radiat Oncol, Taichung, Taiwan.
   [Kao, Chia-Hung] China Med Univ Hosp, Dept Nucl Med, Taichung, Taiwan.
   [Kao, Chia-Hung] China Med Univ Hosp, PET Ctr, Taichung, Taiwan.
C3 E-Da Hospital; I Shou University; China Medical University Taiwan; China
   Medical University Hospital - Taiwan; China Medical University Taiwan; I
   Shou University; China Medical University Taiwan; China Medical
   University Taiwan; China Medical University Taiwan; China Medical
   University Hospital - Taiwan; China Medical University Taiwan; China
   Medical University Hospital - Taiwan; China Medical University Taiwan;
   China Medical University Hospital - Taiwan
RP Kao, CH (corresponding author), China Med Univ, Grad Inst Clin Med Sci, Coll Med, 2 Yuh Der Rd, Taichung 40447, Taiwan.
EM d10040@mail.cmuh.org.tw
RI liang, jian/HNI-8846-2023; Liao, Yu-Chi/AAT-1357-2021; , TC
   Changchien/LGZ-0295-2024
OI Lin, Cheng-Li/0000-0001-9926-3668; , TC Changchien/0009-0009-3120-7569
FU Taiwan Ministry of Health and Welfare Clinical Trial and Research Center
   of Excellence [MOHW104-TDU-B-212-113002]; China Medical University
   Hospital, Academia Sinica Taiwan Biobank, Stroke Biosignature Project
   [BM104010092]; NRPB Stroke Clinical Trial Consortium [MOST
   103-2325-B-039-006]; Tseng-Lien Lin Foundation, Taichung, Taiwan; Taiwan
   Brain Disease Foundation, Taipei, Taiwan; Katsuzo and Kiyo Aoshima
   Memorial Funds, Japan; CMU under the Aim for Top University Plan of the
   Ministry of Education, Taiwan
FX This study is supported in part by Taiwan Ministry of Health and Welfare
   Clinical Trial and Research Center of Excellence
   (MOHW104-TDU-B-212-113002); China Medical University Hospital, Academia
   Sinica Taiwan Biobank, Stroke Biosignature Project (BM104010092); NRPB
   Stroke Clinical Trial Consortium (MOST 103-2325-B-039-006); Tseng-Lien
   Lin Foundation, Taichung, Taiwan; Taiwan Brain Disease Foundation,
   Taipei, Taiwan; Katsuzo and Kiyo Aoshima Memorial Funds, Japan; and CMU
   under the Aim for Top University Plan of the Ministry of Education,
   Taiwan.
CR Akhondzadeh S, 2006, BIPOLAR DISORD, V8, P485, DOI 10.1111/j.1399-5618.2006.00363.x
   Berk M, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-74
   Billiet Laura, 2014, ISRN Rheumatol, V2014, P852954, DOI 10.1155/2014/852954
   Chuang CS, 2014, GEN HOSP PSYCHIAT, V36, P497, DOI 10.1016/j.genhosppsych.2014.05.008
   Chung KH, 2010, PSYCHIAT RES, V180, P147, DOI 10.1016/j.psychres.2009.07.012
   Cronstein BN, 2013, JCR-J CLIN RHEUMATOL, V19, P19, DOI 10.1097/RHU.0b013e31827d8790
   Detka J, 2013, PHARMACOL REP, V65, P1591, DOI 10.1016/S1734-1140(13)71520-2
   Dowlati Y, 2010, BIOL PSYCHIAT, V67, P446, DOI 10.1016/j.biopsych.2009.09.033
   Eyre HA, 2015, PROG NEURO-PSYCHOPH, V57, P11, DOI 10.1016/j.pnpbp.2014.10.003
   Fields RD, 2006, NAT REV NEUROSCI, V7, P423, DOI 10.1038/nrn1928
   Forester BP, 2009, INT J GERIATR PSYCH, V24, P788, DOI 10.1002/gps.2230
   Garcia-Portilla MP, 2008, J AFFECT DISORDERS, V106, P197, DOI 10.1016/j.jad.2007.06.002
   Halmai Z, 2013, J AFFECT DISORDERS, V150, P104, DOI 10.1016/j.jad.2013.02.033
   Henderson DC, 2015, LANCET PSYCHIAT, V2, P452, DOI 10.1016/S2215-0366(15)00115-7
   Hirota T, 2013, SCHIZOPHR RES, V149, P88, DOI 10.1016/j.schres.2013.06.038
   Huang CJ, 2012, GEN HOSP PSYCHIAT, V34, P242, DOI 10.1016/j.genhosppsych.2011.12.011
   Jahangard L, 2014, EUR NEUROPSYCHOPHARM, V24, P1210, DOI 10.1016/j.euroneuro.2014.05.013
   Kesebir S, 2014, J AFFECT DISORDERS, V165, P131, DOI 10.1016/j.jad.2014.04.053
   Kuo CF, 2016, ANN RHEUM DIS, V75, P210, DOI 10.1136/annrheumdis-2014-206410
   Li CG, 2013, CURR OPIN RHEUMATOL, V25, P210, DOI 10.1097/BOR.0b013e32835d951e
   Machado-Vieira R, 2002, MED HYPOTHESES, V58, P297, DOI 10.1054/mehy.2001.1543
   McElroy SL, 2004, J CLIN PSYCHIAT, V65, P634
   Ortiz R, 2015, PROG NEURO-PSYCHOPH, V57, P117, DOI 10.1016/j.pnpbp.2014.10.016
   Prior JA, 2015, SCAND J RHEUMATOL, V44, P257, DOI 10.3109/03009742.2015.1022215
   Renshaw PF, 2001, AM J PSYCHIAT, V158, P2048, DOI 10.1176/appi.ajp.158.12.2048
   Rethorst CD, 2014, J CLIN PSYCHIAT, V75, pE1428, DOI 10.4088/JCP.14m09009
   Rosenblat JD, 2014, PROG NEURO-PSYCHOPH, V53, P23, DOI 10.1016/j.pnpbp.2014.01.013
   Simon GE, 2006, ARCH GEN PSYCHIAT, V63, P824, DOI 10.1001/archpsyc.63.7.824
   Soares Claudio N, 2008, J Clin Psychiatry, V69, pe30
   Sperlagh Beata, 2012, Neuropsychopharmacol Hung, V14, P231
   Ulrich H, 2012, STEM CELL REV REP, V8, P755, DOI 10.1007/s12015-012-9372-9
   Van Durme CM, 2014, COCHRANE DB SYST REV, V9
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vane JR, 2003, THROMB RES, V110, P255, DOI 10.1016/S0049-3848(03)00379-7
   Weiser M, 2014, BIPOLAR DISORD, V16, P441, DOI 10.1111/bdi.12202
NR 35
TC 19
Z9 20
U1 1
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD DEC
PY 2015
VL 94
IS 52
AR e2401
DI 10.1097/MD.0000000000002401
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA DD3XM
UT WOS:000369856700044
PM 26717394
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Toraldo, DM
   De Nuccio, F
   De Benedetto, M
   Scoditti, E
AF Toraldo, D. M.
   De Nuccio, F.
   De Benedetto, M.
   Scoditti, E.
TI Obstructive sleep apnoea syndrome: a new paradigm by chronic nocturnal
   intermittent hypoxia and sleep disruption
SO ACTA OTORHINOLARYNGOLOGICA ITALICA
LA English
DT Review
DE Atherosclerosis; Cancer; Chronic intermittent hypoxia; Obstructive sleep
   apnoea; Sleep disruption
ID POSITIVE AIRWAY PRESSURE; PLASMINOGEN-ACTIVATOR INHIBITOR-1;
   CARDIOVASCULAR RISK-FACTORS; OXIDATIVE STRESS; PLATELET ACTIVATION;
   BLOOD-VISCOSITY; FOLLOW-UP; MORTALITY; COAGULABILITY; ASSOCIATION
AB Obstructive sleep apnoea syndrome (OSAS) is associated with severe cerebro-cardiovascular morbidity and mortality. It is an independent risk factor for atherosclerosis, arterial thrombosis and metabolic syndrome, and recently has been associated with an increased incidence of cancer and death. A causal link between OSAS and atherosclerosis has been partially established. Recent research on atherosclerosis in OSAS has focused on thrombotic tendency and blood viscosity, providing new insight into disease mechanisms. Hypoxia is a critical pathophysiological element in OSAS that leads to intensive sympathetic activity, in association with inflammation, oxidative stress and procoagulant activity. Hypoxia and the induction of oxidative stress can simultaneously represent an underlying mechanism in the pathogenesis of cancer development and progression. This mini-review will discuss the latest findings on the association and potential relationship between OSA and pathological vascular sequelae.
C1 [Toraldo, D. M.] ASL Lecce, V Fazzi Hosp, Rehabil Dept, Resp Care Unit, Lecce, Italy.
   [De Nuccio, F.] Univ Salento, Dept Biol & Environm Sci & Technol, Lab Human Anat & Neurosci, Lecce, Italy.
   [De Benedetto, M.] ASL Lecce, ENT Unit, V Fazzi Hosp, Lecce, Italy.
   [Scoditti, E.] CNR, Inst Clin Physiol, Lecce, Italy.
C3 University of Salento; Consiglio Nazionale delle Ricerche (CNR);
   Istituto di Fisiologia Clinica (IFC-CNR)
RP Toraldo, DM (corresponding author), Via AC Casetti 2, I-73100 Lecce, Italy.
EM d.torald@tin.it
RI De Nuccio, Francesco/GSD-5516-2022; SCODITTI, EGERIA/J-8609-2016
OI TORALDO, Domenico Maurizio/0000-0003-0023-0212; SCODITTI,
   EGERIA/0000-0003-2753-8487; De Nuccio, Francesco/0000-0003-2041-0149
CR Akinnusi ME, 2009, RESPIRATION, V77, P25, DOI 10.1159/000158488
   Almendros I, 2012, EUR RESPIR J, V39, P215, DOI 10.1183/09031936.00185110
   Ambrosetti M, 2004, J THROMB HAEMOST, V2, P1858, DOI 10.1111/j.1538-7836.2004.00913.x
   Martínez-García MA, 2009, AM J RESP CRIT CARE, V180, P36, DOI 10.1164/rccm.200808-1341OC
   Barceló A, 2002, RESP MED, V96, P193, DOI 10.1053/rmed.2001.1239
   Basner RC, 2014, NEW ENGL J MED, V370, P2339, DOI 10.1056/NEJMe1404501
   Bosanquet JP, 2011, CLIN APPL THROMB-HEM, V17, pE119, DOI 10.1177/1076029610389023
   Burioka N, 2009, LIFE SCI, V85, P372, DOI 10.1016/j.lfs.2009.07.002
   Carmeliet P, 1998, NATURE, V394, P485, DOI 10.1038/28867
   Chen L, 2005, AM J RESP CRIT CARE, V172, P915, DOI 10.1164/rccm.200504-560OC
   De Bels D, 2011, NEW ENGL J MED, V365, P1845, DOI [10.1056/NEJMra1011165, 10.1056/NEJMc1110602]
   Drager LF, 2013, AM J RESP CRIT CARE, V188, P240, DOI 10.1164/rccm.201209-1688OC
   Eckert DJ, 2009, PROG CARDIOVASC DIS, V51, P313, DOI 10.1016/j.pcad.2008.02.003
   El Solh AA, 2008, SLEEP BREATH, V12, P331, DOI 10.1007/s11325-008-0182-x
   Epstein MD, 2010, SLEEP, V33, P1069, DOI 10.1093/sleep/33.8.1069
   Gautier-Veyret E, 2013, EUR RESPIR J, V42, P404, DOI 10.1183/09031936.00096512
   Hui DS, 2004, CHEST, V125, P1768, DOI 10.1378/chest.125.5.1768
   de Lima AMJ, 2010, RESPIRATION, V79, P370, DOI 10.1159/000227800
   Jelic S, 2008, CIRCULATION, V117, P2270, DOI 10.1161/CIRCULATIONAHA.107.741512
   Kang JH, 2012, SLEEP MED, V13, P583, DOI 10.1016/j.sleep.2012.03.002
   Kim R, 2014, J CLIN SLEEP MED, V10, P363, DOI 10.5664/jcsm.3602
   Lam DCL, 2015, CLIN ENDOCRINOL, V82, P165, DOI 10.1111/cen.12597
   Lavie L, 2009, EUR RESPIR J, V33, P1467, DOI 10.1183/09031936.00086608
   Lavie L., 2014, SLEEP MED REV
   Lavie L, 2009, PROG CARDIOVASC DIS, V51, P303, DOI 10.1016/j.pcad.2008.08.003
   Liak C, 2011, CAN RESPIR J, V18, P338, DOI 10.1155/2011/924629
   Marshall NS, 2008, SLEEP, V31, P1079
   McNicholas WT, 2007, EUR RESPIR J, V29, P156, DOI 10.1183/09031936.00027406
   Merz CNB, 2009, CIRCULATION, V120, pE100, DOI 10.1161/CIRCULATIONAHA.109.192640
   Mills PJ, 2006, J APPL PHYSIOL, V100, P343, DOI 10.1152/japplphysiol.00494.2005
   Nieto FJ, 2012, AM J RESP CRIT CARE, V186, P190, DOI 10.1164/rccm.201201-0130OC
   Oga T, 2009, J ATHEROSCLER THROMB, V16, P862
   Peker Y, 2014, AM J RESP CRIT CARE, V189, P1345, DOI 10.1164/rccm.201403-0497UP
   Phillips CL, 2012, THORAX, V67, P639, DOI 10.1136/thoraxjnl-2011-200874
   Punjabi NM, 2009, PLOS MED, V6, DOI 10.1371/journal.pmed.1000132
   RANGEMARK C, 1995, SLEEP, V18, P188, DOI 10.1093/sleep/18.3.188
   Reinhart WH, 2002, CLIN HEMORHEOL MICRO, V27, P201
   Ren WY, 2015, INFLAMMATION, V38, P384, DOI 10.1007/s10753-014-0042-8
   Robinson GV, 2004, THORAX, V59, P777, DOI 10.1136/thx.2003.018739
   Ryan S, 2005, CIRCULATION, V112, P2660, DOI 10.1161/CIRCULATIONAHA.105.556746
   Ryan Silke, 2009, Cardiovascular & Hematological Agents in Medicinal Chemistry, V7, P76
   Shamsuzzaman A, 2014, SLEEP BREATH, V18, P761, DOI 10.1007/s11325-014-0938-4
   Sorajja D, 2008, CHEST, V133, P927, DOI 10.1378/chest.07-2544
   Steiner S, 2005, CARDIOLOGY, V104, P92, DOI 10.1159/000086729
   Steiropoulos P, 2007, CHEST, V132, P843, DOI 10.1378/chest.07-0074
   Tanno S, 2014, SLEEP MED
   Tazbirek M, 2009, CLIN HEMORHEOL MICRO, V41, P241, DOI 10.3233/CH-2009-1175
   Testelmans D, 2013, CYTOKINE, V62, P210, DOI 10.1016/j.cyto.2013.02.021
   Tkacova R, 2014, EUR RESPIR J, V44, P931, DOI 10.1183/09031936.00225113
   Toffoli S, 2009, ANGIOGENESIS, V12, P47, DOI 10.1007/s10456-009-9131-y
   Toraldo DM, 2013, J SLEEP DISORDERS TH, V2, P131
   Toraldo DM, 2013, LUNG, V191, P1, DOI 10.1007/s00408-012-9427-3
   von Känel R, 2006, SLEEP BREATH, V10, P139, DOI 10.1007/s11325-006-0060-3
   von Känel R, 2003, CHEST, V124, P1956, DOI 10.1378/chest.124.5.1956
   von Känel R, 2007, METABOLISM, V56, P969, DOI 10.1016/j.metabol.2007.02.010
   Weinreich G, 2013, ATHEROSCLEROSIS, V231, P191, DOI 10.1016/j.atherosclerosis.2013.09.011
   Young T, 2008, SLEEP, V31, P1071
NR 57
TC 27
Z9 29
U1 0
U2 15
PU PACINI EDITORE
PI PISA
PA VIA DELLA GHERARDESCA-ZONA INDUSTRIALE OSPEDALETTO, 56121 PISA, ITALY
SN 0392-100X
EI 1827-675X
J9 ACTA OTORHINOLARYNGO
JI Acta Otorhinolaryngol. Ital.
PD APR
PY 2015
VL 35
IS 2
BP 69
EP 74
PG 6
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA CJ2MI
UT WOS:000355318500001
PM 26019388
DA 2025-06-11
ER

PT J
AU Falkner, B
   Gidding, SS
   Baker-Smith, CM
   Brady, TM
   Flynn, JT
   Malle, LM
   South, AM
   Tran, AH
   Urbina, EM
AF Falkner, Bonita
   Gidding, Samuel S.
   Baker-Smith, Carissa M.
   Brady, Tammy M.
   Flynn, Joseph T.
   Malle, Leslie M.
   South, Andrew M.
   Tran, Andrew H.
   Urbina, Elaine M.
CA Amer Heart Assoc Council Hypertens
   Council Lifelong Congenital Heart
   Council Kidney Cardiovasc Dis
   Council Lifestyle Cardiometab Hlth
   Council Cardiovasc Stroke Nursing
TI Pediatric Primary Hypertension: An Underrecognized Condition: A
   Scientific Statement From the American Heart Association
SO HYPERTENSION
LA English
DT Article
DE AHA Scientific Statements; blood pressure; cardiovascular diseases;
   child; hypertension; obesity
ID HIGH BLOOD-PRESSURE; CARDIOMETABOLIC RISK-FACTORS; PHYSICAL-ACTIVITY;
   EUROPEAN-SOCIETY; CHILDREN; CHILDHOOD; ADULTHOOD; OBESITY; TRAJECTORIES;
   GUIDELINES
AB The overall prevalence of hypertension in childhood is 2% to 5%, and the leading type of childhood hypertension is primary hypertension, especially in adolescence. As in adults, the leading risk factors for children with primary hypertension are excess adiposity and suboptimal lifestyles; however, environmental stress, low birth weight, and genetic factors may also be important. Hypertensive children are highly likely to become hypertensive adults and to have measurable target organ injury, particularly left ventricular hypertrophy and vascular stiffening. Ambulatory and home blood pressure monitoring may facilitate diagnosis. Primordial prevention of hypertension through public health implementation of healthier diet and increased physical activity will reduce the prevalence of primary hypertension, and evidence-based treatment guidelines should be implemented when hypertension is diagnosed. Further research to optimize recognition and diagnosis and clinical trials to better define outcomes of treatment are needed.
RI Tran, Andrew/G-1795-2018; Falkner, Bonita/Y-8451-2019; Baker-Smith,
   Carissa/ABL-0815-2022
OI Baker-Smith, Carissa/0000-0002-7528-1586
CR Arif M, 2019, HYPERTENS RES, V42, P1099, DOI 10.1038/s41440-019-0248-0
   Baker-Smith CM, 2021, J AM HEART ASSOC, V10, DOI 10.1161/JAHA.121.022427
   Bijlsma MW, 2014, J PEDIATR-US, V164, P173, DOI 10.1016/j.jpeds.2013.08.066
   BLUMENTHAL S, 1977, PEDIATRICS, V59, P797
   Chen XL, 2008, CIRCULATION, V117, P3171, DOI 10.1161/CIRCULATIONAHA.107.730366
   Cogswell ME, 2017, AM J CLIN NUTR, V106, P530, DOI 10.3945/ajcn.116.145623
   Couch SC, 2021, HYPERTENSION, V77, P241, DOI 10.1161/HYPERTENSIONAHA.120.16156
   Ducharme-Smith K, 2021, J NUTR, V151, P1609, DOI 10.1093/jn/nxab027
   Ekelund U, 2012, JAMA-J AM MED ASSOC, V307, P704, DOI 10.1001/jama.2012.156
   Falkner B, 2020, HYPERTENSION, V75, P1142, DOI 10.1161/HYPERTENSIONAHA.119.14059
   Flynn JT, 2017, PEDIATRICS, V140, DOI [10.1542/peds.2017-3035, 10.1542/peds.2017-1904]
   Flynn JT, 2022, HYPERTENSION, V79, pE114, DOI 10.1161/HYP.0000000000000215
   Flynn JT, 2022, CIRC RES, V130, P800, DOI 10.1161/CIRCRESAHA.121.319819
   Gidding SS, 2018, HYPERTENSION, V72, P834, DOI 10.1161/HYPERTENSIONAHA.118.11575
   Hardy ST, 2021, JAMA NETW OPEN, V4, DOI 10.1001/jamanetworkopen.2021.3917
   Hendriksen MAH, 2014, AM J CLIN NUTR, V99, P446, DOI 10.3945/ajcn.113.062018
   Jacobs DR Jr, 2022, NEW ENGL J MED, V386, P1877, DOI 10.1056/NEJMoa2109191
   Kelly RK, 2015, J PEDIATR-US, V167, P1422, DOI 10.1016/j.jpeds.2015.07.055
   Kharbanda EO, 2018, PEDIATRICS, V141, DOI 10.1542/peds.2017-2954
   Köchli S, 2019, HYPERTENSION, V73, P153, DOI 10.1161/HYPERTENSIONAHA.118.11872
   Koebnick C, 2018, J CLIN HYPERTENS, V20, P174, DOI 10.1111/jch.13159
   Kotsis V, 2010, HYPERTENS RES, V33, P386, DOI 10.1038/hr.2010.9
   Lande MB, 2018, J PEDIATR-US, V195, P85, DOI 10.1016/j.jpeds.2017.12.013
   Lang RM, 2015, EUR HEART J-CARD IMG, V16, P233, DOI 10.1093/ehjci/jev014
   Leyvraz M, 2018, INT J EPIDEMIOL, V47, P1796, DOI 10.1093/ije/dyy121
   Li J, 2022, ENVIRON INT, V161, DOI 10.1016/j.envint.2022.107134
   Li Y, 2020, CURR HYPERTENS REP, V22, DOI 10.1007/s11906-020-01044-2
   Llewellyn A, 2016, OBES REV, V17, P56, DOI 10.1111/obr.12316
   Lurbe E, 2018, HYPERTENSION, V71, P437, DOI 10.1161/HYPERTENSIONAHA.117.10529
   Lurbe E, 2016, J HYPERTENS, V34, P1887, DOI 10.1097/HJH.0000000000001039
   Manosroi W, 2019, ENDOCR REV, V40, P825, DOI 10.1210/er.2018-00071
   Martin-Smith R, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17082955
   Muntner P, 2019, HYPERTENSION, V73, pE35, DOI 10.1161/HYP.0000000000000087
   Olczak KJ, 2021, J INTERN MED, V290, P1130, DOI 10.1111/joim.13352
   Rabi DM, 2020, CAN J CARDIOL, V36, P596, DOI 10.1016/j.cjca.2020.02.086
   Rinke ML, 2019, PEDIATR QUAL SAF, V4, DOI 10.1097/pq9.0000000000000187
   Rosettie KL, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0200378
   Song PG, 2019, JAMA PEDIATR, V173, P1154, DOI 10.1001/jamapediatrics.2019.3310
   South AM, 2019, PEDIATR NEPHROL, V34, P1583, DOI 10.1007/s00467-019-04253-3
   South AM, 2019, CLIN SCI, V133, P55, DOI 10.1042/CS20171550
   Stergiou GS, 2018, J HYPERTENS, V36, P479, DOI 10.1097/HJH.0000000000001635
   STRIDE BP, About  us
   Su SY, 2015, CIRCULATION, V131, P1674, DOI 10.1161/CIRCULATIONAHA.114.013104
   Suglia SF, 2018, CIRCULATION, V137, pE15, DOI 10.1161/CIR.0000000000000536
   Theodore RF, 2015, HYPERTENSION, V66, P1108, DOI 10.1161/HYPERTENSIONAHA.115.05831
   Tran AH, 2020, HYPERTENSION, V75, P1551, DOI 10.1161/HYPERTENSIONAHA.119.14682
   U.S. Department of Health and Human Services and U.S. Department of Agriculture, 2015-2020 Dietary Guidelines for Americans
   Urbina EM, 2019, HYPERTENSION, V74, P590, DOI 10.1161/HYPERTENSIONAHA.119.13027
   .validateBP, US blood pressure validated device listing
   Welch WP, 2012, J CLIN HYPERTENS, V14, P388, DOI 10.1111/j.1751-7176.2012.00656.x
   Wühl E, 2009, NEW ENGL J MED, V361, P1639, DOI 10.1056/NEJMoa0902066
   Yalçin SS, 2022, BMC NEPHROL, V23, DOI 10.1186/s12882-022-02774-y
   Yang LL, 2020, HYPERTENSION, V75, P948, DOI 10.1161/HYPERTENSIONAHA.119.14168
NR 53
TC 61
Z9 66
U1 9
U2 20
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD JUN
PY 2023
VL 80
IS 6
BP E101
EP E111
DI 10.1161/HYP.0000000000000228
PG 11
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA H9IX3
UT WOS:000999023600002
PM 36994715
OA Bronze
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Prince, SA
   Rasmussen, CL
   Biswas, A
   Holtermann, A
   Aulakh, T
   Merucci, K
   Coenen, P
AF Prince, Stephanie A.
   Rasmussen, Charlotte Lund
   Biswas, Aviroop
   Holtermann, Andreas
   Aulakh, Tarnbir
   Merucci, Katherine
   Coenen, Pieter
TI The effect of leisure time physical activity and sedentary behaviour on
   the health of workers with different occupational physical activity
   demands: a systematic review
SO INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
LA English
DT Review
DE Physical activity; Sedentary behaviour; Occupation; Leisure;
   Cardiovascular disease; Mortality
ID ALL-CAUSE MORTALITY; CORONARY-HEART-DISEASE; ACUTE
   MYOCARDIAL-INFARCTION; LOW-BACK-PAIN; CARDIOVASCULAR-DISEASE;
   CARDIORESPIRATORY FITNESS; EXERCISE PROGRAM; FINNISH MEN; NECK PAIN;
   FOLLOW-UP
AB Background: Although it is generally accepted that physical activity reduces the risk for chronic non-communicable disease and mortality, accumulating evidence suggests that occupational physical activity (OPA) may not confer the same health benefits as leisure time physical activity (LTPA). It is also unclear if workers in high OPA jobs benefit from LTPA the same way as those in sedentary jobs. Our objective was to determine whether LTPA and leisure time sedentary behaviour (LTSB) confer the same health effects across occupations with different levels of OPA.
   Methods: Searches were run in Medline, Embase, PsycINFO, ProQuest Public Health and Scopus from inception to June 9, 2020. Prospective or experimental studies which examined the effects of LTPA or LTSB on all-cause and cardiovascular mortality and cardiovascular disease, musculoskeletal pain, diabetes, metabolic syndrome, arrhythmias and depression among adult workers grouped by OPA (low OPA/sitters, standers, moderate OPA/intermittent movers, high OPA/heavy labourers) were eligible. Results were synthesized using narrative syntheses and harvest plots, and certainty of evidence assessed with GRADE.
   Results: The review includes 38 papers. Across all outcomes, except cardiovascular mortality, metabolic syndrome and atrial fibrillation, greater LTPA was consistently protective among low OPA, but conferred less protection among moderate and high OPA. For cardiovascular mortality and metabolic syndrome, higher levels of LTPA were generally associated with similar risk reductions among all OPA groups. Few studies examined effects in standers and none examined effects of LTSB across OPA groups.
   Conclusions: Evidence suggests that LTPA is beneficial for all workers, but with larger risk reductions among those with low compared to high OPA jobs. This suggests that, in our attempts to improve the health of workers through LTPA, tailored interventions for different occupational groups may be required. More high-quality studies are needed to establish recommended levels of LTPA/LTSB for different OPA groups.
C1 [Prince, Stephanie A.] Publ Hlth Agcy Canada, Ctr Surveillance & Appl Res, 785 Carling Ave, Ottawa, ON K1A 0K9, Canada.
   [Prince, Stephanie A.] Univ Ottawa, Fac Med, Sch Epidemiol & Publ Hlth, Ottawa, ON, Canada.
   [Rasmussen, Charlotte Lund; Holtermann, Andreas] Natl Res Ctr Working Environm, Copenhagen, Denmark.
   [Biswas, Aviroop] Inst Work & Hlth, Toronto, ON, Canada.
   [Biswas, Aviroop] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada.
   [Aulakh, Tarnbir] Queens Univ, Sch Kinesiol & Hlth Studies, Kingston, ON, Canada.
   [Merucci, Katherine] Hlth Canada, Hlth Lib, Ottawa, ON, Canada.
   [Coenen, Pieter] Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Dept Publ & Occupat Hlth, Amsterdam UMC, Amsterdam, Netherlands.
C3 Public Health Agency of Canada; University of Ottawa; National Research
   Centre for the Working Environment; Institute for Work & Health;
   University of Toronto; Queens University - Canada; Health Canada; Vrije
   Universiteit Amsterdam; University of Amsterdam
RP Prince, SA (corresponding author), Publ Hlth Agcy Canada, Ctr Surveillance & Appl Res, 785 Carling Ave, Ottawa, ON K1A 0K9, Canada.; Prince, SA (corresponding author), Univ Ottawa, Fac Med, Sch Epidemiol & Publ Hlth, Ottawa, ON, Canada.
EM stephanie.princeware@canada.ca
RI Coenen, Pieter/H-8195-2019; Prince, Stephanie/J-9361-2019; Lund
   Rasmussen, Charlotte/HKW-5734-2023
OI Merucci, Katherine/0000-0003-1981-7013; Coenen,
   Pieter/0000-0002-4034-7063; Biswas, Aviroop/0000-0002-0393-6280;
   Holtermann, Andreas/0000-0003-4825-5697; Lund Rasmussen,
   Charlotte/0000-0003-2193-5019; Prince, Stephanie/0000-0001-6729-5649
CR Ainsworth BE, 2011, MED SCI SPORT EXER, V43, P1575, DOI 10.1249/MSS.0b013e31821ece12
   Allesoe K, 2015, EUR J PREV CARDIOL, V22, P1601, DOI 10.1177/2047487314554866
   Andersen LL, 2012, SCAND J WORK ENV HEA, V38, P582, DOI 10.5271/sjweh.3310
   Andersen LL, 2016, OCCUP ENVIRON MED, V73, P246, DOI 10.1136/oemed-2015-103314
   [Anonymous], 2018, 2018 physical activity guidelines advisory committee scientific report
   Aune D, 2015, EUR J EPIDEMIOL, V30, P529, DOI 10.1007/s10654-015-0056-z
   Bahls M, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-34468-7
   Balshem H, 2011, J CLIN EPIDEMIOL, V64, P401, DOI 10.1016/j.jclinepi.2010.07.015
   Barengo NC, 2004, EUR HEART J, V25, P2204, DOI 10.1016/j.ehj.2004.10.009
   Bernaards CM, 2006, OCCUP ENVIRON MED, V63, P10, DOI 10.1136/oem.2004.017541
   Biswas A, 2021, AM J PREV MED, V60, pE149, DOI 10.1016/j.amepre.2020.09.017
   Biswas A, 2020, J APPL GERONTOL, V39, P214, DOI 10.1177/0733464818755313
   Biswas A, 2015, ANN INTERN MED, V162, P123, DOI 10.7326/M14-1651
   Bull FC, 2020, BRIT J SPORT MED, V54, P1451, DOI 10.1136/bjsports-2020-102955
   Burn NL, 2019, SPORTS MED, V49, P1255, DOI 10.1007/s40279-019-01125-6
   CASPERSEN CJ, 1985, PUBLIC HEALTH REP, V100, P126
   Cillekens B, 2020, BRIT J SPORT MED, V54, P1474, DOI 10.1136/bjsports-2020-102587
   Clays E, 2014, AM J EPIDEMIOL, V179, P559, DOI 10.1093/aje/kwt294
   Clays E, 2013, EUR J EPIDEMIOL, V28, P241, DOI 10.1007/s10654-013-9764-4
   Clays E, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-1002
   Coenen P, 2017, OCCUP ENVIRON MED, V74, DOI [10.1136/oemed-2017-104636.9, DOI 10.1136/OEMED-2017-104636.9]
   Coenen P, 2020, BRIT J SPORT MED, V54, P1055, DOI 10.1136/bjsports-2019-101343
   Coenen P, 2018, BRIT J SPORT MED, V52, P1320, DOI 10.1136/bjsports-2017-098540
   Coenen P, 2018, BRIT J SPORT MED, V52, P174, DOI 10.1136/bjsports-2016-096795
   Fan MY, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.119.012556
   Ferrario MM, 2018, HEART, V104, P1165, DOI 10.1136/heartjnl-2017-312594
   Fransson E, 2004, EPIDEMIOLOGY, V15, P573, DOI 10.1097/01.ede.0000134865.74261.fe
   Gommans FG, 2016, J OCCUP ENVIRON MED, V58, pE140, DOI 10.1097/JOM.0000000000000687
   Gordon-Larsen P, 2009, ARCH INTERN MED, V169, P1216, DOI 10.1001/archinternmed.2009.163
   Halim I, 2012, SAF HEALTH WORK, V3, P31, DOI 10.5491/SHAW.2012.3.1.31
   Harari G, 2015, OCCUP ENVIRON MED, V72, P617, DOI 10.1136/oemed-2014-102613
   Haukka E, 2012, OCCUP ENVIRON MED, V69, P485, DOI 10.1136/oemed-2011-100453
   Hengel KMO, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-1008
   Henriques-Neto D, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17082721
   Hermansen R, 2019, EUR J PREV CARDIOL, V26, P1636, DOI 10.1177/2047487319848205
   HOLME I, 1981, ACTA MED SCAND, V209, P277
   Holtermann A, 2009, INT ARCH OCC ENV HEA, V82, P1015, DOI 10.1007/s00420-009-0401-1
   Holtermann A., 2020, Handbook of socioeconomic determinants of occupational health - from macro-level to micro-level evidence, P1
   Holtermann A, 2018, BRIT J SPORT MED, V52, P149, DOI 10.1136/bjsports-2017-097965
   Holtermann A, 2016, SCAND J WORK ENV HEA, V42, P291, DOI 10.5271/sjweh.3563
   Holtermann A, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054548
   Holtermann A, 2012, BMJ OPEN, V2, DOI 10.1136/bmjopen-2011-000556
   Holtermann A, 2012, BMJ OPEN, V2, DOI 10.1136/bmjopen-2011-000279
   Holtermann A, 2010, SCAND J WORK ENV HEA, V36, P357, DOI 10.5271/sjweh.2913
   Holtermann A, 2009, SCAND J WORK ENV HEA, V35, P466, DOI 10.5271/sjweh.1357
   Howley ET, 2001, MED SCI SPORT EXER, V33, pS364, DOI 10.1097/00005768-200106001-00005
   Hu G, 2005, STROKE, V36, P1994, DOI 10.1161/01.STR.0000177868.89946.0c
   Hu G, 2007, ATHEROSCLEROSIS, V194, P490, DOI 10.1016/j.atherosclerosis.2006.08.051
   Jakobsen MD, 2015, SCAND J WORK ENV HEA, V41, P153, DOI 10.5271/sjweh.3479
   Kirk MA, 2011, AM J PREV MED, V40, P476, DOI 10.1016/j.amepre.2010.12.015
   Korhonen T, 2003, OCCUP ENVIRON MED, V60, P475, DOI 10.1136/oem.60.7.475
   Korshoj M, 2013, ERGONOMICS, V56, P935, DOI 10.1080/00140139.2013.782427
   Kuwahara K, 2016, ENDOCRINE, V53, P710, DOI 10.1007/s12020-016-0911-z
   Lerche AF, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17207419
   Lewis JE, 2011, J OCCUP ENVIRON MED, V53, P1115, DOI 10.1097/JOM.0b013e31822cfe8e
   Li J, 2013, CURR OPIN CARDIOL, V28, P575, DOI 10.1097/HCO.0b013e328364289c
   Lin XC, 2015, J AM HEART ASSOC, V4, DOI 10.1161/JAHA.115.002014
   McGuinness LA, 2021, RES SYNTH METHODS, V12, P55, DOI 10.1002/jrsm.1411
   Messing K, 2004, CAN J APPL PHYSIOL, V29, P639, DOI 10.1139/h04-041
   Miranda H, 2001, OCCUP ENVIRON MED, V58, P528, DOI 10.1136/oem.58.8.528
   MORRIS JN, 1958, BMJ-BRIT MED J, V2, P1485, DOI 10.1136/bmj.2.5111.1485
   Murad M Hassan, 2017, Evid Based Med, V22, P85, DOI 10.1136/ebmed-2017-110668
   Nordander C, 2016, APPL ERGON, V55, P70, DOI 10.1016/j.apergo.2016.01.010
   Ogilvie D, 2008, BMC MED RES METHODOL, V8, DOI 10.1186/1471-2288-8-8
   PAFFENBA.RS, 1970, NEW ENGL J MED, V282, P1109, DOI 10.1056/NEJM197005142822001
   Page MJ, 2021, BMJ-BRIT MED J, V372, DOI [10.1136/bmj.n71, 10.1136/bmj.n160]
   Pedersen MT, 2013, BMC MUSCULOSKEL DIS, V14, DOI 10.1186/1471-2474-14-287
   Petersen CB, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-1070
   Poitras VJ, 2016, APPL PHYSIOL NUTR ME, V41, pS197, DOI 10.1139/apnm-2015-0663
   Prince SA, 2019, INT J BEHAV NUTR PHY, V16, DOI 10.1186/s12966-019-0790-9
   Pulsford RM, 2015, INT J EPIDEMIOL, V44, P1909, DOI 10.1093/ije/dyv191
   Reid CR, 2010, INT J IND ERGONOM, V40, P247, DOI 10.1016/j.ergon.2010.01.003
   RIIHIMAKI H, 1994, SPINE, V19, P138, DOI 10.1097/00007632-199401001-00003
   Ruzic L, 2003, OCCUP ENVIRON MED, V60, P983, DOI 10.1136/oem.60.12.983
   SALONEN JT, 1988, AM J EPIDEMIOL, V127, P87, DOI 10.1093/oxfordjournals.aje.a114794
   Samitz G, 2011, INT J EPIDEMIOL, V40, P1382, DOI 10.1093/ije/dyr112
   Saunders TJ, 2020, APPL PHYSIOL NUTR ME, V45, pS197, DOI 10.1139/apnm-2020-0272
   Schmidt SCE, 2017, BIOMED RES INT, V2017, DOI 10.1155/2017/1785217
   Sihawong R, 2014, EUR SPINE J, V23, P786, DOI 10.1007/s00586-014-3212-3
   Sihawong R, 2014, OCCUP ENVIRON MED, V71, P63, DOI 10.1136/oemed-2013-101561
   Skielboe AK, 2016, EUR J PREV CARDIOL, V23, P1883, DOI 10.1177/2047487316655464
   Smith P, 2018, AM J EPIDEMIOL, V187, P27, DOI 10.1093/aje/kwx298
   Stamatakis E, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0073753
   Sterne JAC, 2019, BMJ-BRIT MED J, V366, DOI 10.1136/bmj.l4898
   Stevens ML, 2020, ANN WORK EXPOS HEAL, V64, P138, DOI 10.1093/annweh/wxz095
   Stevens ML, 2021, INT ARCH OCC ENV HEA, V94, P503, DOI 10.1007/s00420-020-01596-5
   Strain T, 2020, BRIT J SPORT MED, V54, P1488, DOI 10.1136/bjsports-2020-102601
   Tremblay MS, 2017, INT J BEHAV NUTR PHY, V14, DOI 10.1186/s12966-017-0525-8
   van den Heuvel SG, 2005, PREV MED, V41, P260, DOI 10.1016/j.ypmed.2004.11.006
   Wang AL, 2016, SCAND J WORK ENV HEA, V42, P423, DOI 10.5271/sjweh.3580
   Wang CL, 2019, J GERONTOL A-BIOL, V74, P1952, DOI 10.1093/gerona/gly288
   Wang YJ, 2010, J AM COLL CARDIOL, V56, P1140, DOI 10.1016/j.jacc.2010.05.035
   Waters TR, 2015, REHABIL NURS, V40, P148, DOI 10.1002/rnj.166
   World Health Organizatin, 2020, WHO guidelines on physical activity and sedentary behaviour
   Yip VYB, 2004, J ADV NURS, V46, P430, DOI 10.1111/j.1365-2648.2004.03009.x
   Zeiher J, 2019, SPORTS MED-OPEN, V5, DOI 10.1186/s40798-019-0211-2
   Zhu XM, 2020, BUILD ENVIRON, V168, DOI 10.1016/j.buildenv.2019.106455
NR 97
TC 81
Z9 87
U1 11
U2 37
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1479-5868
J9 INT J BEHAV NUTR PHY
JI Int. J. Behav. Nutr. Phys. Act.
PD JUL 20
PY 2021
VL 18
IS 1
AR 100
DI 10.1186/s12966-021-01166-z
PG 17
WC Nutrition & Dietetics; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics; Physiology
GA TL5KB
UT WOS:000674895300001
PM 34284795
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Prossin, AR
   Zalcman, SS
   Evans, SJ
   McInnis, MG
   Ellingrod, VL
AF Prossin, Alan R.
   Zalcman, Steven S.
   Evans, Simon J.
   McInnis, McInnis G.
   Ellingrod, Vicki L.
TI A Pilot Study Investigating Tumor Necrosis Factor-α as a Potential
   Intervening Variable of Atypical Antipsychotic-Associated Metabolic
   Syndrome in Bipolar Disorder
SO THERAPEUTIC DRUG MONITORING
LA English
DT Article
DE cytokines; psychoneuroimmunology; bipolar disorder; metabolic syndrome;
   mediation; atypical antipsychotic; tumor necrosis factor
ID TNF-ALPHA; PREVALENCE; ADULTS; GENES; TRIAL; RISK
AB Background: Strong associations exist between tumor necrosis factor-alpha (TNF-alpha) and metabolic syndrome (MetS). Although TNF-a is associated with bipolar depression (BD), its role in atypical antipsychotic (AAP)-associated MetS in BD is unclear. Here, we investigate the potential intervening role of TNF-alpha in the indirect relationship between AAP treatment and MetS in BD.
   Materials and Methods: Using a cross-sectional design, 99 euthymic BD volunteers were stratified by the presence or the absence of MetS (National Cholesterol Education Program Adult Treatment Panel III). Serum TNF-alpha concentration, determined via chemiluminescent immunometric assays, was compared between groups (ie, MetS or no MetS). We investigated the intervening effect of TNF-alpha on the relation between AAP treatment and MetS in BD using regression techniques.
   Results: Treatment with those antipsychotics believed associated with a higher risk for MetS (ie, AAPs: olanzapine, quetiapine, risperidone, paliperidone, clozapine) was found to be associated with significantly greater TNF-alpha (F-1,F-88 = 11.2, P = 0.001, mean difference of 1.7 +/- 0.51) and a higher likelihood of MetS (F-1,F-88 = 4.5, P = 0.036) than in those not receiving treatment with an AAP. Additionally, TNF-alpha was greater (trending toward significance; T-52 = 2.0, P = 0.05) in BD volunteers with MetS and was found to have a statistically significant effect on the indirect relationship between AAP treatment and elevated waist circumference in these BD volunteers.
   Discussion: These results identify TNF-alpha as a potential intervening variable of AAP-associated MetS in BD, not previously identified in this population. Future prospective studies could assess the predictive potential of TNF-alpha in determining risk of AAP-associated MetS in BD. Given previous evidence relating TNF-alpha and mood state in BD, this study increases the importance in understanding the role of TNF-alpha in "mind-body" interactions and renews discussions of the utility of research into the clinical efficacy of TNF-alpha antagonist treatment in mood disorders.
C1 [Prossin, Alan R.; Evans, Simon J.; McInnis, McInnis G.; Ellingrod, Vicki L.] Univ Michigan, Sch Med, Dept Psychiat, Ann Arbor, MN USA.
   [Zalcman, Steven S.] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Psychiat, Newark, NJ 07103 USA.
   [Ellingrod, Vicki L.] Univ Michigan, Coll Pharm, Ann Arbor, MN USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences
RP Prossin, AR (corresponding author), Univ Michigan, Sch Med, Dept Psychiat, 4250 Plymouth Rd,2409, Ann Arbor, MI 48109 USA.
EM prossin@med.umich.edu
RI Ellingrod, Vicki/G-8764-2012; McInnis, Melvin/F-6963-2012; Prossin,
   Alan/K-2967-2015
OI Evans, Simon/0000-0001-8112-9487; Prossin, Alan/0000-0003-1262-522X
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [DK020572]; National Institute of Diabetes and Digestive and Kidney
   Diseases [P30DK020572] Funding Source: NIH RePORTER
FX This work used the Chemistry Core of the Michigan Diabetes Research and
   Training Center funded by DK020572 from the National Institute of
   Diabetes and Digestive and Kidney Diseases.
CR Andreasen NC, 2010, BIOL PSYCHIAT, V67, P255, DOI 10.1016/j.biopsych.2009.08.040
   Basile VS, 2001, J CLIN PSYCHIAT, V62, P45
   BECK AT, 1993, SUICIDE LIFE-THREAT, V23, P139
   Berkley KJ, 2006, AM J PHYSIOL-REG I, V291, pR241, DOI 10.1152/ajpregu.00287.2006
   Brietzke E, 2010, PSYCHIAT CLIN NEUROS, V64, P442, DOI 10.1111/j.1440-1819.2010.02096.x
   Brietzke E, 2009, J AFFECT DISORDERS, V116, P214, DOI 10.1016/j.jad.2008.12.001
   Cardenas J, 2008, J AFFECT DISORDERS, V106, P91, DOI 10.1016/j.jad.2007.05.030
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Correll CU, 2008, BIPOLAR DISORD, V10, P788, DOI 10.1111/j.1399-5618.2008.00625.x
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   Fagiolini A, 2008, CNS DRUGS, V22, P655, DOI 10.2165/00023210-200822080-00004
   Fiedorowicz JG, 2008, ANN CLIN PSYCHIATRY, V20, P131, DOI 10.1080/10401230802177722
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Garcia-Portilla MP, 2008, J AFFECT DISORDERS, V106, P197, DOI 10.1016/j.jad.2007.06.002
   Grundy SM, 2004, ARTERIOSCL THROM VAS, V24, pE13, DOI 10.1161/01.ATV.0000111245.75752.C6
   Guo JJ, 2007, PSYCHIAT SERV, V58, P1073, DOI 10.1176/appi.ps.58.8.1073
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Hayes AF, 2011, COMMUN SER, P434
   Hayes AF, 2010, MULTIVAR BEHAV RES, V45, P627, DOI 10.1080/00273171.2010.498290
   Hayes AF, 2009, COMMUN MONOGR, V76, P408, DOI 10.1080/03637750903310360
   Kemp DE, 2010, J CLIN PSYCHIAT, V71, P1138, DOI 10.4088/JCP.09m05159gre
   Kern PA, 1997, J NUTR, V127, pS1917, DOI 10.1093/jn/127.9.1917S
   Kim YK, 2004, PSYCHIAT RES, V129, P267, DOI 10.1016/j.psychres.2004.08.005
   Kim YK, 2007, J AFFECT DISORDERS, V104, P91, DOI 10.1016/j.jad.2007.02.018
   Koh KK, 2005, J AM COLL CARDIOL, V46, P1978, DOI 10.1016/j.jacc.2005.06.082
   Kunz M, 2011, REV BRAS PSIQUIATR, V33, P268, DOI 10.1590/S1516-44462011005000009
   Lee SC, 2000, METABOLISM, V49, P1021, DOI 10.1053/meta.2000.7704
   Lieberman JA, 2005, NEW ENGL J MED, V353, P1209, DOI 10.1056/NEJMoa051688
   Mathieu JE, 2006, J PERS SOC PSYCHOL, V89, P12
   Meyer JM, 2008, SCHIZOPHR RES, V101, P273, DOI 10.1016/j.schres.2007.12.487
   Orrell A, 2007, EUR J CARDIOV PREV R, V14, P615, DOI 10.1097/HJR.0b013e3280ecfd56
   Preacher KJ, 2004, BEHAV RES METH INS C, V36, P717, DOI 10.3758/BF03206553
   Saghizadeh M, 1996, J CLIN INVEST, V97, P1111, DOI 10.1172/JCI118504
   STEPHENS JM, 1992, J BIOL CHEM, V267, P13580
   STEPHENS JM, 1992, J BIOL CHEM, V267, P8336
   Taylor V, 2006, J CLIN PSYCHIAT, V67, P1034, DOI 10.4088/JCP.v67n0704
   van Winkel R, 2008, BIPOLAR DISORD, V10, P342, DOI 10.1111/j.1399-5618.2007.00520.x
   Vuksan-Cusa B, 2011, PSYCHIAT RES, V189, P21, DOI 10.1016/j.psychres.2010.11.021
   Woods SW, 2003, J CLIN PSYCHIAT, V64, P663, DOI 10.4088/JCP.v64n0607
   Yumru M, 2007, J AFFECT DISORDERS, V98, P247, DOI 10.1016/j.jad.2006.08.009
NR 40
TC 7
Z9 7
U1 0
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0163-4356
EI 1536-3694
J9 THER DRUG MONIT
JI Ther. Drug Monit.
PD APR
PY 2013
VL 35
IS 2
BP 194
EP 202
DI 10.1097/FTD.0b013e31827e18d2
PG 9
WC Medical Laboratory Technology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Medical Laboratory Technology; Pharmacology & Pharmacy; Toxicology
GA 107DE
UT WOS:000316194100007
PM 23503445
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Bakke, J
   Haj, FG
AF Bakke, Jesse
   Haj, Fawaz G.
TI Protein-tyrosine phosphatase 1B substrates and metabolic regulation
SO SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
LA English
DT Review
DE PTP1B; Substrate; Obesity; Diabetes; ER stress; Pyruvate kinase
ID ENDOPLASMIC-RETICULUM STRESS; PYRUVATE-KINASE M2; INSULIN-RECEPTOR;
   BODY-WEIGHT; GLUCOSE-HOMEOSTASIS; SIGNAL-TRANSDUCTION; NEGATIVE
   REGULATION; MASS-SPECTROMETRY; REDOX REGULATION; S-NITROSYLATION
AB Metabolic homeostasis requires integration of complex signaling networks which, when deregulated, contribute to metabolic syndrome and related disorders. Protein-tyrosine phosphatase 1B (PTP1B) has emerged as a key regulator of signaling networks that are implicated in metabolic diseases such as obesity and type 2 diabetes. In this review, we examine mechanisms that regulate PTP1B-substrate interaction, enzymatic activity and experimental approaches to identify PTP1B substrates. We then highlight findings that implicate PTP1B in metabolic regulation. In particular, insulin and leptin signaling are discussed as well as recently identified PTP1B substrates that are involved in endoplasmic reticulum stress response, cell-cell communication, energy balance and vesicle trafficking. In summary, PTP1B exhibits exquisite substrate specificity and is an outstanding pharmaceutical target for obesity and type 2 diabetes. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Bakke, Jesse; Haj, Fawaz G.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Haj, Fawaz G.] Univ Calif Davis, Dept Internal Med, Div Endocrinol Diabet & Metab, Sacramento, CA 95817 USA.
   [Haj, Fawaz G.] Univ Calif Davis, Ctr Comprehens Canc, Sacramento, CA 95817 USA.
C3 University of California System; University of California Davis;
   University of California System; University of California Davis;
   University of California System; University of California Davis
RP Haj, FG (corresponding author), Univ Calif Davis, Dept Nutr, 3135 Meyer Hall, Davis, CA 95616 USA.
EM fghaj@ucdavis.edu
OI Bakke, Jesse/0000-0003-0305-5165
FU Juvenile Diabetes Research Foundation; American Diabetes Association;
   National Institutes of Health [R56 DK084317, R01 DK090492, R01 DK095359,
   K99 DK100736]
FX Thanks to Dr. Ahmed Bettaieb for comments on the manuscript and
   preparing the figure. Research in the Haj laboratory is supported by
   grants from Juvenile Diabetes Research Foundation, American Diabetes
   Association and National Institutes of Health (R56 DK084317, R01
   DK090492 and R01 DK095359 to F.G.H. and K99 DK100736 to A.B.).
CR Agotini A, 2011, BIOCHEM J, V2, P369
   Ahima RS, 2004, PHYSIOL BEHAV, V81, P223, DOI 10.1016/j.physbeh.2004.02.014
   AHMAD F, 1995, J BIOL CHEM, V270, P20503, DOI 10.1074/jbc.270.35.20503
   Anderie I, 2007, CELL SIGNAL, V19, P582, DOI 10.1016/j.cellsig.2006.08.007
   Avruch J, 1998, MOL CELL BIOCHEM, V182, P31, DOI 10.1023/A:1006823109415
   Bakke J, 2013, CELL COMMUN SIGNAL, V11, DOI 10.1186/1478-811X-11-57
   Balsamo J, 1996, J CELL BIOL, V134, P801, DOI 10.1083/jcb.134.3.801
   Bandyopadhyay D, 1997, J BIOL CHEM, V272, P1639, DOI 10.1074/jbc.272.3.1639
   Barford D, 1998, ANNU REV BIOPH BIOM, V27, P133, DOI 10.1146/annurev.biophys.27.1.133
   Barr AJ, 2010, FUTURE MED CHEM, V2, P1563, DOI 10.4155/FMC.10.241
   Bence KK, 2006, NAT MED, V12, P917, DOI 10.1038/nm1435
   Bettaieb A, 2013, J BIOL CHEM, V288, P17360, DOI 10.1074/jbc.M112.441469
   Bettaieb A, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0034412
   Bettaieb A, 2011, J BIOL CHEM, V286, P9225, DOI 10.1074/jbc.M110.186148
   Biddinger SB, 2006, ANNU REV PHYSIOL, V68, P123, DOI 10.1146/annurev.physiol.68.040104.124723
   Boubekeur S, 2011, J BIOL CHEM, V286, P19373, DOI 10.1074/jbc.M111.222984
   Boute N, 2003, EMBO REP, V4, P313, DOI 10.1038/sj.embor.embor767
   BROWNSHIMER S, 1990, P NATL ACAD SCI USA, V87, P5148, DOI 10.1073/pnas.87.13.5148
   Bryant NJ, 2002, NAT REV MOL CELL BIO, V3, P267, DOI 10.1038/nrm782
   CHARBONNEAU H, 1989, P NATL ACAD SCI USA, V86, P5252, DOI 10.1073/pnas.86.14.5252
   Cheatham B, 1996, P NATL ACAD SCI USA, V93, P15169, DOI 10.1073/pnas.93.26.15169
   Chen YY, 2007, METHODS, V42, P243, DOI 10.1016/j.ymeth.2007.03.002
   Chen YY, 2008, J BIOL CHEM, V283, P35265, DOI 10.1074/jbc.M805287200
   Cheng A, 2002, DEV CELL, V2, P497, DOI 10.1016/S1534-5807(02)00149-1
   Christofk HR, 2008, NATURE, V452, P230, DOI 10.1038/nature06734
   Christofk HR, 2008, NATURE, V452, P181, DOI 10.1038/nature06667
   CICIRELLI MF, 1990, P NATL ACAD SCI USA, V87, P5514, DOI 10.1073/pnas.87.14.5514
   Cromlish WA, 2006, BIOCHEM PHARMACOL, V72, P1279, DOI 10.1016/j.bcp.2006.07.038
   Dadke S, 2000, J BIOL CHEM, V275, P23642, DOI 10.1074/jbc.M001063200
   Dadke S, 2001, MOL CELL BIOCHEM, V221, P147, DOI 10.1023/A:1010909031310
   Dadke S, 2007, NAT CELL BIOL, V9, P80, DOI 10.1038/ncb1522
   Delibegovic M, 2007, MOL CELL BIOL, V27, P7727, DOI 10.1128/MCB.00959-07
   Delibegovic M, 2009, DIABETES, V58, P590, DOI 10.2337/db08-0913
   Denu JM, 1998, CURR OPIN CHEM BIOL, V2, P633, DOI 10.1016/S1367-5931(98)80095-1
   Eden ER, 2010, NAT CELL BIOL, V12, P267, DOI 10.1038/ncb2026
   Elchebly M, 1999, SCIENCE, V283, P1544, DOI 10.1126/science.283.5407.1544
   Feldhammer M, 2013, CRIT REV BIOCHEM MOL, V48, P430, DOI 10.3109/10409238.2013.819830
   Flint AJ, 1997, P NATL ACAD SCI USA, V94, P1680, DOI 10.1073/pnas.94.5.1680
   FLINT AJ, 1993, EMBO J, V12, P1937, DOI 10.1002/j.1460-2075.1993.tb05843.x
   FRANGIONI JV, 1992, CELL, V68, P545, DOI 10.1016/0092-8674(92)90190-N
   FRANGIONI JV, 1993, EMBO J, V12, P4843, DOI 10.1002/j.1460-2075.1993.tb06174.x
   Garton AJ, 1996, MOL CELL BIOL, V16, P6408
   Goldberg MS, 2012, J EXP MED, V209, P217, DOI 10.1084/jem.20111487
   Goldstein BJ, 2000, J BIOL CHEM, V275, P4283, DOI 10.1074/jbc.275.6.4283
   Grant L, 2014, DIABETES, V63, P456, DOI 10.2337/db13-0885
   Gu F, 2004, J BIOL CHEM, V279, P49689, DOI 10.1074/jbc.C400261200
   Hai FG, 2002, SCIENCE, V295, P1708
   Haj FG, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036633
   Haj FG, 2005, J BIOL CHEM, V280, P15038, DOI 10.1074/jbc.M413240200
   Haj FG, 2003, J BIOL CHEM, V278, P739, DOI 10.1074/jbc.M210194200
   Haque A, 2011, CELL, V147, P185, DOI 10.1016/j.cell.2011.08.036
   Harding HP, 1999, NATURE, V397, P271, DOI 10.1038/16729
   He RJ, 2013, FEBS J, V280, P731, DOI 10.1111/j.1742-4658.2012.08718.x
   Hitosugi T, 2009, SCI SIGNAL, V2, DOI 10.1126/scisignal.2000431
   Hummasti S, 2010, CIRC RES, V107, P579, DOI 10.1161/CIRCRESAHA.110.225698
   Jain R, 2013, DIABETOLOGIA, V56, P1350, DOI 10.1007/s00125-013-2877-1
   Jewell JL, 2011, J CELL BIOL, V193, P185, DOI 10.1083/jcb.201007176
   Kaufman RJ, 2002, NAT REV MOL CELL BIO, V3, P411, DOI 10.1038/nrm829
   KAYNE FJ, 1973, ARCH BIOCHEM BIOPHYS, V159, P292, DOI 10.1016/0003-9861(73)90455-4
   Kenner KA, 1996, J BIOL CHEM, V271, P19810, DOI 10.1074/jbc.271.33.19810
   Klaman LD, 2000, MOL CELL BIOL, V20, P5479, DOI 10.1128/MCB.20.15.5479-5489.2000
   Konstantinova I, 2007, CELL, V129, P359, DOI 10.1016/j.cell.2007.02.044
   Krishnan N, 2011, SCI SIGNAL, V4, DOI 10.1126/scisignal.2002329
   Kushner JA, 2004, DIABETES, V53, P61, DOI 10.2337/diabetes.53.1.61
   Lee SR, 1998, J BIOL CHEM, V273, P15366, DOI 10.1074/jbc.273.25.15366
   Liang FB, 2005, J BIOL CHEM, V280, P24857, DOI 10.1074/jbc.M502780200
   Liu F, 1997, BIOCHEM J, V327, P139, DOI 10.1042/bj3270139
   Liu F, 1996, J BIOL CHEM, V271, P31290, DOI 10.1074/jbc.271.49.31290
   Liu S, 2014, ENDOCRINOLOGY
   Lohse DL, 1997, BIOCHEMISTRY-US, V36, P4568, DOI 10.1021/bi963094r
   Luo J, 2005, CELL CYCLE, V4, P1309, DOI 10.4161/cc.4.10.2062
   Ma YL, 2001, RAPID COMMUN MASS SP, V15, P1693, DOI 10.1002/rcm.426
   Macintyre AN, 2011, MOL CELL, V42, P713, DOI 10.1016/j.molcel.2011.06.003
   Matsuo K, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0016446
   MAURO LJ, 1994, TRENDS BIOCHEM SCI, V19, P151, DOI 10.1016/0968-0004(94)90274-7
   Meng TC, 2004, J BIOL CHEM, V279, P37716, DOI 10.1074/jbc.M404606200
   Mertins P, 2008, MOL CELL PROTEOMICS, V7, P1763, DOI 10.1074/mcp.M800196-MCP200
   Mustelin T, 2002, FRONT BIOSCI-LANDMRK, V7, pD85, DOI 10.2741/mustelin
   Myers MP, 2001, J BIOL CHEM, V276, P47771, DOI 10.1074/jbc.C100583200
   Nakamura Y, 2008, CIRC RES, V102, P1182, DOI 10.1161/CIRCRESAHA.107.167080
   Nievergall E, 2010, J CELL BIOL, V191, P1189, DOI 10.1083/jcb.201005035
   Owen C, 2013, DIABETOLOGIA, V56, P2286, DOI 10.1007/s00125-013-2992-z
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Panzhinskiy E, 2013, DIABETOLOGIA, V56, P598, DOI 10.1007/s00125-012-2782-z
   Pasquale EB, 2008, CELL, V133, P38, DOI 10.1016/j.cell.2008.03.011
   Pathre P, 2001, J NEUROSCI RES, V63, P143, DOI 10.1002/1097-4547(20010115)63:2<143::AID-JNR1006>3.0.CO;2-1
   PELLEYMOUNTER MA, 1995, SCIENCE, V269, P540, DOI 10.1126/science.7624776
   Rask-Madsen C, 2012, ARTERIOSCL THROM VAS, V32, P2052, DOI 10.1161/ATVBAHA.111.241919
   Ravichandran LV, 2001, MOL ENDOCRINOL, V15, P1768, DOI 10.1210/me.15.10.1768
   Ravier MA, 2005, DIABETES, V54, P1798, DOI 10.2337/diabetes.54.6.1798
   Rhee S G, 2000, Sci STKE, V2000, ppe1
   Romsicki Y, 2004, J BIOL CHEM, V279, P12868, DOI 10.1074/jbc.M309600200
   Ron D, 2007, NAT REV MOL CELL BIO, V8, P519, DOI 10.1038/nrm2199
   Salmeen A, 2005, ANTIOXID REDOX SIGN, V7, P560, DOI 10.1089/ars.2005.7.560
   Salmeen A, 2003, NATURE, V423, P769, DOI 10.1038/nature01680
   Salmeen A, 2000, MOL CELL, V6, P1401, DOI 10.1016/S1097-2765(00)00137-4
   Seely BL, 1996, DIABETES, V45, P1379, DOI 10.2337/diabetes.45.10.1379
   Shifrin VI, 1997, J BIOL CHEM, V272, P2957, DOI 10.1074/jbc.272.5.2957
   Spiegelman BM, 2001, CELL, V104, P531, DOI 10.1016/S0092-8674(01)00240-9
   Stuible M, 2008, J BIOL CHEM, V283, P15740, DOI 10.1074/jbc.M710534200
   Stuible M, 2010, J BIOL CHEM, V285, P23899, DOI 10.1074/jbc.M110.115295
   Su Q, 2008, J BIOL CHEM, V283, P469, DOI 10.1074/jbc.M704612200
   SUN H, 1994, TRENDS BIOCHEM SCI, V19, P480, DOI 10.1016/0968-0004(94)90134-1
   Swarbrick MM, 2009, ENDOCRINOLOGY, V150, P1670, DOI 10.1210/en.2008-0885
   Taniguchi CM, 2006, NAT REV MOL CELL BIO, V7, P85, DOI 10.1038/nrm1837
   Tao JC, 2001, J BIOL CHEM, V276, P29520, DOI 10.1074/jbc.M103721200
   Tartaglia LA, 1997, J BIOL CHEM, V272, P6093, DOI 10.1074/jbc.272.10.6093
   TELLAM JT, 1995, J BIOL CHEM, V270, P5857, DOI 10.1074/jbc.270.11.5857
   Thurmond DC, 1998, J BIOL CHEM, V273, P33876, DOI 10.1074/jbc.273.50.33876
   Tiganis T, 2013, FEBS J, V280, P445, DOI 10.1111/j.1742-4658.2012.08563.x
   Tonks NK, 2006, NAT REV MOL CELL BIO, V7, P833, DOI 10.1038/nrm2039
   Tonks NK, 2003, FEBS LETT, V546, P140, DOI 10.1016/S0014-5793(03)00603-3
   TONKS NK, 1990, MOL CELL BIOL, V10, P458, DOI 10.1128/MCB.10.2.458
   Tonks NK, 2001, CURR OPIN CELL BIOL, V13, P182, DOI 10.1016/S0955-0674(00)00196-4
   Trümpler A, 2009, FEBS J, V276, P5622, DOI 10.1111/j.1742-4658.2009.07255.x
   Tsou RC, 2014, MOL METAB, V3, P301, DOI 10.1016/j.molmet.2014.01.008
   Tsou RC, 2012, ENDOCRINOLOGY, V153, P4227, DOI 10.1210/en.2012-1548
   van Montfort RLM, 2003, NATURE, V423, P773, DOI 10.1038/nature01681
   Vila-Bedmar R, 2010, ENDOCRINOLOGY, V151, P980, DOI 10.1210/en.2009-0810
   WOODFORDTHOMAS TA, 1992, J CELL BIOL, V117, P401, DOI 10.1083/jcb.117.2.401
   Xie LP, 2002, BIOCHEMISTRY-US, V41, P4032, DOI 10.1021/bi015904r
   Xu G, 2004, J CELL SCI, V117, P3207, DOI 10.1242/jcs.01174
   Xue B, 2009, MOL CELL BIOL, V29, P4563, DOI 10.1128/MCB.01914-08
   Yamada E, 1999, BIOCHEM BIOPH RES CO, V256, P257, DOI 10.1006/bbrc.1999.0228
   Yip SC, 2012, J CELL SCI, V125, P310, DOI 10.1242/jcs.086256
   Yip SC, 2010, TRENDS BIOCHEM SCI, V35, P442, DOI 10.1016/j.tibs.2010.03.004
   Zabolotny JM, 2002, DEV CELL, V2, P489, DOI 10.1016/S1534-5807(02)00148-X
   Zabolotny JM, 2004, J BIOL CHEM, V279, P24844, DOI 10.1074/jbc.M310688200
   ZHANG M, 1994, BIOCHEMISTRY-US, V33, P11097, DOI 10.1021/bi00203a006
   Zhang S, 2007, DRUG DISCOV TODAY, V12, P373, DOI 10.1016/j.drudis.2007.03.011
   ZHANG YY, 1994, NATURE, V372, P425, DOI 10.1038/372425a0
   Zinker BA, 2002, P NATL ACAD SCI USA, V99, P11357, DOI 10.1073/pnas.142298199
NR 132
TC 123
Z9 134
U1 1
U2 37
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1084-9521
J9 SEMIN CELL DEV BIOL
JI Semin. Cell Dev. Biol.
PD JAN
PY 2015
VL 37
BP 58
EP 65
DI 10.1016/j.semcdb.2014.09.020
PG 8
WC Cell Biology; Developmental Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Developmental Biology
GA CC2ES
UT WOS:000350158600009
PM 25263014
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Schuler, BR
   Gardenhire, RA
   Jones, SD
   Spilsbury, JC
   Moore, SM
   Borawski, EA
AF Schuler, Brittany R.
   Gardenhire, Rachel A.
   Jones, Sarah D.
   Spilsbury, James C.
   Moore, Shirley M.
   Borawski, Elaine A.
TI Exploring the Association Between Trauma, Instability, and Youth
   Cardiometabolic Health Outcomes Over Three Years
SO JOURNAL OF ADOLESCENT HEALTH
LA English
DT Article
DE Adverse childhood experiences; Trauma; Instability; Low-income;
   Adolescence; Cardiometabolic risk; Obesity; Diabetes
ID ADVERSE CHILDHOOD EXPERIENCES; RISK; ADOLESCENTS; BEHAVIORS; CHILDREN;
   OBESITY; STRESS; SCALE
AB Purpose: Childhood adversity plays a fundamental role in predicting youth cardiometabolic health. Our understanding of how adverse experiences in childhood should best be conceptualized remains elusive, based on one-dimensional measures of adversity. The present study fills a major gap in existing research by examining two distinct forms of threat and instability -related exposures that may impact cardiometabolic risk (CMR) in adolescence. Methods: We explore two specific subtypes of adversity: trauma (e.g., badly hurt, victim of crime, loss of close person) and instability (e.g., moving, change of schools, change in household structure) as differential influences that can accumulate to impact early childhood onset of CMR (body mass index, high -density lipoprotein (HDL), low -density lipoprotein, diastolic and systolic blood pressure, triglycerides, C -reactive protein, insulin sensitivity). Secondary data were drawn from a randomized control behavioral trial of youth recruited during sixth grade from urban Cleveland (Ohio) schools beginning in 2012-2014 (n 1/4 360) and followed for 3 years. Participants reported on 12 adverse experiences, six trauma- and six instability -specific. Multiple regression assessed effects of prospective and accumulative indices of trauma and instability with 3 -year trajectories of eight objective CMR markers. Results: Instability was associated with increased body mass index, decreased high -density lipoprotein, and increased C -reactive protein slopes. Trauma was associated with trends in triglyceride levels but not with any other CMR outcomes. Discussion: Experiences with instability distinctly impacted adolescent CMR. Future research is needed to examine factors that can enhance stability for families in marginalized communities. (c) 2023 Society for Adolescent Health and Medicine. Published by Elsevier Inc. This is an open access article under the CC BY -NC -ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Schuler, Brittany R.] Temple Univ, Coll Publ Hlth, Sch Social Work, Philadelphia, PA USA.
   [Gardenhire, Rachel A.] Case Western Reserve Univ, Sch Med, Cleveland, OH USA.
   [Jones, Sarah D.] Dominican Univ, Borra Coll Hlth Sci Nutr, River Forest, IL USA.
   [Spilsbury, James C.] Case Western Reserve Univ, Sch Med, Dept Populat & Quantitat Hlth Sci, Cleveland, OH USA.
   [Moore, Shirley M.] Case Western Reserve Univ, Frances Payne Bolton Sch Nursing, Cleveland, OH USA.
   [Borawski, Elaine A.] Case Western Reserve Univ, Dept Nutr, Cleveland, OH USA.
   [Schuler, Brittany R.] Temple Univ, Sch Social Work, 1301 Cecil B Moore Ave Ritter Annex 549, Philadelphia, PA 19122 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple
   University; University System of Ohio; Case Western Reserve University;
   University System of Ohio; Case Western Reserve University; University
   System of Ohio; Case Western Reserve University; University System of
   Ohio; Case Western Reserve University; Pennsylvania Commonwealth System
   of Higher Education (PCSHE); Temple University
RP Schuler, BR (corresponding author), Temple Univ, Sch Social Work, 1301 Cecil B Moore Ave Ritter Annex 549, Philadelphia, PA 19122 USA.
EM brittany.schuler@temple.edu
RI Spilsbury, James/O-6880-2019; Moore, Shirley/AAB-8911-2019; Borawski,
   Elaine/R-9959-2019
OI Schuler, Brittany/0000-0002-2869-6260
FU National Institute on Minority Health and Health Disparities of the
   National Institutes of Health [K01MD015326]; National Heart, Lung, and
   Blood Institute of the National Institutes of Health [U01 HL103622];
   Prevention Research Centers Program of the Centers for Disease Control
   and Prevention [U48DP005030]
FX This study was supported by the National Institute on Minority Health
   and Health Disparities of the National Institutes of Health to Brittany
   R. Schuler (Grant Number K01MD015326) . This is a secondary study of
   research supported by the National Heart, Lung, and Blood Institute of
   the National Institutes of Health (Grant Number U01 HL103622) and the
   Prevention Research Centers Program of the Centers for Disease Control
   and Prevention (Grant Number U48DP005030) ; Clinicaltrials.gov
   #NCT01514279) .
CR Andrade JL, 2021, J PEDIATR-US, V237, P267, DOI 10.1016/j.jpeds.2021.06.024
   Berman IS, 2022, DEV PSYCHOPATHOL, V34, P499, DOI 10.1017/S0954579421001826
   Brewerton TD, 2022, J EAT DISORD, V10, DOI 10.1186/s40337-022-00696-6
   Brown DW, 2009, AM J PREV MED, V37, P389, DOI 10.1016/j.amepre.2009.06.021
   Bureau of Labor Statistics Reports, 2017, Consumer expenditures in 2017
   Bureau UC, 2022, Quick facts, Cleaveland city, Ohio. United States Census Bureau. Quick Facts Web site
   Burgard SA, 2014, SOC SCI MED, V106, P143, DOI 10.1016/j.socscimed.2014.01.045
   Chissini RDC, 2020, NUTRITION, V71, DOI 10.1016/j.nut.2019.110608
   Cole MB, 2022, AM J PREV MED, V62, P670, DOI 10.1016/j.amepre.2021.11.008
   Datar A, 2013, AM J EPIDEMIOL, V177, P1065, DOI 10.1093/aje/kws353
   Daundasekara SS, 2020, J YOUTH ADOLESCENCE, V49, P1645, DOI 10.1007/s10964-020-01249-3
   Desmond Matthew., 2015, RSF: The Russell Sage Foundation Journal of the Social Sciences, V1, P1
   Doom JR, 2020, SOC SCI MED, V258, DOI 10.1016/j.socscimed.2020.113083
   Doom JR, 2019, J PEDIATR-US, V209, P85, DOI 10.1016/j.jpeds.2019.01.058
   Doom JR, 2017, SOC SCI MED, V188, P166, DOI 10.1016/j.socscimed.2017.06.044
   Doom JR, 2016, DEV PSYCHOPATHOL, V28, P1505, DOI 10.1017/S0954579415001169
   Dube SR, 2009, PSYCHOSOM MED, V71, P243, DOI 10.1097/PSY.0b013e3181907888
   Ellis BJ, 2022, DEV PSYCHOPATHOL, V34, P447, DOI 10.1017/S0954579421001838
   Felitti VJ., 1998, J FAMILY CONSUMER SC, V90, P31
   Flynn JT, 2017, PEDIATRICS, V140, DOI [10.1542/peds.2017-3035, 10.1542/peds.2017-1904]
   Flynn JT, 2020, PEDIATRICS, V146, DOI 10.1542/peds.2020-018481
   Forsyth A, 2015, J ADOLESCENT HEALTH, V57, P222, DOI 10.1016/j.jadohealth.2015.05.003
   Friedman EM, 2015, J AGING HEALTH, V27, P1311, DOI 10.1177/0898264315580122
   Garner T., 2008, Creating a consistent poverty measure over time using NAS procedures: 1996-2005
   Greeson JKP, 2011, CHILD WELFARE, V90, P91
   Groenwold RHH, 2021, EUR J ENDOCRINOL, V184, pE11, DOI 10.1530/EJE-20-1375
   Jones BL, 2014, FRONT PSYCHOL, V5, DOI 10.3389/fpsyg.2014.00374
   Kelly JB, 2003, FAM RELAT, V52, P352, DOI 10.1111/j.1741-3729.2003.00352.x
   Lipina S., 2005, Interamerican Journal of Psychology, V39, P49
   Lumeng JC, 2013, PEDIATRICS, V132, pE1506, DOI 10.1542/peds.2013-1111
   Maner JK, 2023, J BEHAV MED, V46, P417, DOI 10.1007/s10865-022-00373-8
   Martinez JL, 2022, DEV PSYCHOPATHOL, V34, P705, DOI 10.1017/S0954579421001607
   McEwen BS, 2005, J PSYCHIATR NEUROSCI, V30, P315
   McLaughlin KA, 2014, NEUROSCI BIOBEHAV R, V47, P578, DOI 10.1016/j.neubiorev.2014.10.012
   Moore SM, 2019, PEDIATRICS, V143, DOI 10.1542/peds.2018-2185
   Moore SM, 2013, CONTEMP CLIN TRIALS, V36, P574, DOI 10.1016/j.cct.2013.08.009
   National Heart Lung and Blood Institute, 2022, High blood triglycerides
   Nord M, 2007, J NUTR, V137, P533, DOI 10.1093/jn/137.3.533
   Ranganathan Priya, 2016, Perspect Clin Res, V7, P106, DOI 10.4103/2229-3485.179436
   Rosenberg D, 2009, PREV MED, V49, P213, DOI 10.1016/j.ypmed.2009.07.011
   Schlenz H, 2014, INT J OBESITY, V38, pS26, DOI 10.1038/ijo.2014.132
   Schuler BR, 2023, PREV MED REP, V31, DOI 10.1016/j.pmedr.2022.102071
   Schuler BR, 2022, SSM-POPUL HLTH, V19, DOI 10.1016/j.ssmph.2022.101197
   Schuler BR, 2021, PREV MED, V145, DOI 10.1016/j.ypmed.2021.106447
   Schuler BR, 2020, PUBLIC HEALTH NUTR, V23, P2781, DOI 10.1017/S1368980020001366
   Schuler BR, 2019, SOC WORK HEALTH CARE, V58, P952, DOI 10.1080/00981389.2019.1680478
   Shonkoff JP, 2012, PEDIATRICS, V129, pE232, DOI 10.1542/peds.2011-2663
   Sonu S, 2019, PREV MED, V123, P163, DOI 10.1016/j.ypmed.2019.03.032
   Standford Children's Health, 2022, Cholesterol, LDL, HDL, and triglycerides in children and teens
   van den Berg GJ, 2014, J EUR ECON ASSOC, V12, P1521, DOI 10.1111/jeea.12112
   Wells NM, 2010, AM J PUBLIC HEALTH, V100, P2507, DOI 10.2105/AJPH.2009.184291
   Willett W., 2012, NUTR EPIDEMIOLOGY
   Wiss DA, 2020, PHYSIOL BEHAV, V223, DOI 10.1016/j.physbeh.2020.112964
   Yang YC, 2021, P NATL ACAD SCI USA, V118, DOI 10.1073/pnas.2020167118
   YEAWORTH RC, 1992, ADOLESCENCE, V27, P783
NR 55
TC 1
Z9 1
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1054-139X
EI 1879-1972
J9 J ADOLESCENT HEALTH
JI J. Adolesc. Health
PD FEB
PY 2024
VL 74
IS 2
BP 301
EP 311
DI 10.1016/j.jadohealth.2023.08.049
EA JAN 2024
PG 11
WC Psychology, Developmental; Public, Environmental & Occupational Health;
   Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Public, Environmental & Occupational Health; Pediatrics
GA HY2U1
UT WOS:001163013600001
PM 37843478
OA hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Quesada, I
   de Paola, M
   Torres-Palazzolo, C
   Camargo, A
   Ferder, L
   Manucha, W
   Castro, C
AF Quesada, Isabel
   de Paola, Matilde
   Torres-Palazzolo, Carolina
   Camargo, Alejandra
   Ferder, Leon
   Manucha, Walter
   Castro, Claudia
TI Effect of Garlic's Active Constituents in Inflammation, Obesity and
   Cardiovascular Disease
SO CURRENT HYPERTENSION REPORTS
LA English
DT Review
DE Garlic; Organosulfur compounds; Atherosclerosis; Overweight;
   Mitochondria dysfunction; Oxidative stress
ID ALLIUM-SATIVUM L.; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION;
   DIALLYL-DISULFIDE; ENDOTHELIAL FUNCTION; METABOLIC SYNDROME;
   ORGANOSULFUR COMPOUNDS; BIOACTIVE COMPOUNDS; INSULIN-RESISTANCE;
   SULFUR-COMPOUNDS
AB Purpose of Review Several studies have attributed garlic's beneficial properties to its high content of organosulfur compounds (OSCs). Here, we summarized recent studies published and some own findings regarding OSCs and its effects on cardiovascular disease, inflammation, and obesity. Recent Finding The analysis of the multiple actions produced by OSCs suggests that many of its bioactivities interfere against inflammation, oxidative stress, obesogenic effects, and mitochondrial dysfunction. Accumulating evidence from in vitro, animal, and human studies reinforce the notion that OSCs modify signaling pathways that trigger chronic diseases, and to highlight, actions over these pathways are related to the treatment of disorders addressed in this review. Garlic's bioactive OSCs behave like a nutraceutical panacea because they cover a broad spectrum of applications with promising impact for the prevention and treatment of prevalent chronic pathologies associated with low-grade inflammation.
C1 [Quesada, Isabel; de Paola, Matilde; Manucha, Walter; Castro, Claudia] Consejo Nacl Invest Cient & Tecn, Inst Med & Expt Biol Cuyo IMBECU, Mendoza, Argentina.
   [Quesada, Isabel; de Paola, Matilde; Manucha, Walter; Castro, Claudia] Univ Nacl Cuyo, Fac Ciencias Med Mendoza, Mendoza, Argentina.
   [Torres-Palazzolo, Carolina; Camargo, Alejandra] Consejo Nacl Invest Cient & Tecn, Agr Biol Inst Mendoza IBAM, Mendoza, Argentina.
   [Torres-Palazzolo, Carolina; Camargo, Alejandra] Univ Nacl Cuyo, Fac Ciencias Agr Mendoza, Mendoza, Argentina.
   [Ferder, Leon] Univ Miami, Miller Sch Med, Dept Pediat, Div Nephrol, Miami, FL 33136 USA.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   Instituto de Medicina y BiologIa Experimental de Cuyo (IMBECU);
   University Nacional Cuyo Mendoza; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); University Nacional Cuyo Mendoza;
   University of Miami
RP Castro, C (corresponding author), Consejo Nacl Invest Cient & Tecn, Inst Med & Expt Biol Cuyo IMBECU, Mendoza, Argentina.; Castro, C (corresponding author), Univ Nacl Cuyo, Fac Ciencias Med Mendoza, Mendoza, Argentina.
EM ccastro@fcm.uncu.edu.ar
OI Torres Palazzolo, Carolina/0000-0003-1412-9836; Castro,
   Claudia/0000-0002-8428-2484; Camargo, Alejandra
   Beatriz/0000-0001-9749-8842; Manucha, Walter/0000-0002-2279-7626
FU Secretary of Science, Technology and Posgrade [06/J469, 06/J514];
   Universidad Nacional de Cuyo, Mendoza Argentina; PIP-CONICET
   [PICT-2013-2379, PICT-2016-4541]
FX Authors received the following grants: from the Secretary of Science,
   Technology and Posgrade No. 06/J469 (to CC) and No. 06/J514 (to WM),
   Universidad Nacional de Cuyo, Mendoza Argentina; PIP-CONICET 2015-17 (to
   CC); PICT-2013-2379 (to AC) and PICT-2016-4541 (to WM).
CR Al-Rasheed N, 2014, J OLEO SCI, V63, P839, DOI 10.5650/jos.ess14027
   Amano H, 2015, DRUG METAB DISPOS, V43, P749, DOI 10.1124/dmd.115.063230
   Annamalai S, 2017, BIOMED PHARMACOTHER, V93, P81, DOI 10.1016/j.biopha.2017.06.035
   [Anonymous], 2018, CIRCULATION, DOI DOI 10.1161/CIR.0000000000000558
   Morales-González JA, 2019, FOODS, V8, DOI 10.3390/foods8080343
   Arent SM, 2018, J AM COLL NUTR, V37, P111, DOI 10.1080/07315724.2017.1368039
   Arreola R, 2015, J IMMUNOL RES, V2015, DOI 10.1155/2015/401630
   Atkin M, 2016, J DIABETES COMPLICAT, V30, P723, DOI 10.1016/j.jdiacomp.2016.01.003
   Ba L, 2019, PHYTOMEDICINE, V58, DOI 10.1016/j.phymed.2018.11.025
   Bae J, 2019, J NUTR BIOCHEM, V64, P152, DOI 10.1016/j.jnutbio.2018.10.014
   Bhuiyan AI, 2015, MOLECULES, V20, P1731, DOI 10.3390/molecules20011731
   Block E, 2010, J AGR FOOD CHEM, V58, P4617, DOI 10.1021/jf1000106
   Camargo AB, 2017, CLIN INVEST ARTERIOS, V29, P36, DOI 10.1016/j.arteri.2016.05.004
   Charron CS, 2015, J NUTR, V145, P2448, DOI 10.3945/jn.115.215392
   Choudhary Prema Ram, 2018, Journal of Dietary Supplements, V15, P499, DOI 10.1080/19390211.2017.1358233
   Cornelius C, 2013, IMMUN AGEING, V10, DOI 10.1186/1742-4933-10-15
   Dehghani S, 2018, PHYTOMEDICINE, V48, P70, DOI 10.1016/j.phymed.2018.04.060
   Demine S, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8080795
   Feng C, 2017, INFLAMMATION, V40, P818, DOI 10.1007/s10753-017-0526-4
   Galal Heba M, 2019, Pathophysiology, V26, P271, DOI 10.1016/j.pathophys.2019.07.002
   Trejo EMAG, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18091980
   Gruhlke MCH, 2019, FREE RADICAL BIO MED, V131, P144, DOI 10.1016/j.freeradbiomed.2018.11.022
   Hurtado-Barroso S, 2019, NUTRIENTS, V11, DOI 10.3390/nu11040851
   Prado NJ, 2018, J PINEAL RES, V65, DOI 10.1111/jpi.12513
   Kattoor AJ, 2017, CURR ATHEROSCLER REP, V19, DOI 10.1007/s11883-017-0678-6
   Kim EJ, 2012, J NUTR BIOCHEM, V23, P1552, DOI 10.1016/j.jnutbio.2011.10.008
   Kirichenko TV, 2017, PHYTOTHER RES, V31, P1209, DOI 10.1002/ptr.5841
   Lai YS, 2014, J AGR FOOD CHEM, V62, P5897, DOI 10.1021/jf500803c
   Lawson LD, 2018, NUTRIENTS, V10, DOI 10.3390/nu10070812
   Lee CG, 2019, J NUTR BIOCHEM, V64, P13, DOI 10.1016/j.jnutbio.2018.09.014
   Lee HS, 2016, J MED FOOD, V19, P823, DOI 10.1089/jmf.2016.3674
   Lee IC, 2014, FOOD CHEM TOXICOL, V63, P174, DOI 10.1016/j.fct.2013.11.006
   Lembede BW, 2018, J DEV ORIG HLTH DIS, V9, P160, DOI [10.1017/S2040174417000940, 10.1017/s2040174417000940]
   Lembede Busisani W, 2018, Prev Nutr Food Sci, V23, P15, DOI 10.3746/pnf.2018.23.1.15
   Lii CK, 2012, FOOD CHEM TOXICOL, V50, P478, DOI 10.1016/j.fct.2011.11.020
   Liu H, 2015, CELL PHYSIOL BIOCHEM, V36, P966, DOI 10.1159/000430271
   Liu SG, 2015, FOOD FUNCT, V6, P321, DOI 10.1039/c4fo00761a
   Locatelli DA, 2014, FOOD CHEM, V157, P199, DOI 10.1016/j.foodchem.2014.02.010
   Mahdavi-Roshan M, 2017, ANATOL J CARDIOL, V18, P116, DOI 10.14744/AnatolJCardiol.2017.7669
   Maiese K, 2017, CURR NEUROVASC RES, V14, P415, DOI 10.2174/1567202614666171116102911
   Mansour MH, 2013, INFLAMMOPHARMACOLOGY, V21, P147, DOI 10.1007/s10787-012-0139-3
   Manucha W, 2015, CURR HYPERTENS REP, V17, DOI 10.1007/s11906-014-0504-2
   Manucha W, 2014, MEDICINA-BUENOS AIRE, V74, P254
   Marchio P, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8563845
   Martins N, 2016, FOOD CHEM, V211, P41, DOI 10.1016/j.foodchem.2016.05.029
   Maslov LN, 2019, J CLIN TRANSL ENDOCR, V15, P1, DOI 10.1016/j.jcte.2018.11.001
   Matsumoto S, 2016, J NUTR, V146, p427S, DOI 10.3945/jn.114.202424
   Mattson MP, 2006, TRENDS NEUROSCI, V29, P632, DOI 10.1016/j.tins.2006.09.001
   Meldrum DR, 2017, FERTIL STERIL, V107, DOI 10.1016/j.fertnstert.2017.02.104
   Marón FJM, 2019, STRESS, V22, P169, DOI 10.1080/10253890.2018.1542683
   Mofrad MD, 2021, INT J VITAM NUTR RES, V91, P370, DOI 10.1024/0300-9831/a000607
   Mofrad MD, 2019, J NUTR, V149, P605, DOI 10.1093/jn/nxy310
   Moriya J, 2019, J CARDIOL, V73, P22, DOI 10.1016/j.jjcc.2018.05.010
   Moutia M, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/4984659
   Mozaffarian D, 2016, CIRCULATION, V133, P187, DOI 10.1161/CIRCULATIONAHA.115.018585
   Myasoedova VA, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17081318
   Nillert N, 2017, NUTRIENTS, V9, DOI 10.3390/nu9010024
   Pérez-Torres I, 2016, MOLECULES, V21, DOI 10.3390/molecules21111425
   Pintana H, 2014, APPL PHYSIOL NUTR ME, V39, P1373, DOI 10.1139/apnm-2014-0255
   Putnik P, 2019, FOOD CHEM, V276, P680, DOI 10.1016/j.foodchem.2018.10.068
   Raggi P, 2018, ATHEROSCLEROSIS, V276, P98, DOI 10.1016/j.atherosclerosis.2018.07.014
   Ramalingam L, 2017, BBA-MOL BASIS DIS, V1863, P1106, DOI 10.1016/j.bbadis.2016.07.019
   Ramirez DA, 2017, J FOOD COMPOS ANAL, V61, P4, DOI 10.1016/j.jfca.2016.09.012
   Rastogi S, 2016, PHYTOMEDICINE, V23, P1082, DOI 10.1016/j.phymed.2015.10.012
   Riad K, 2018, FRONT NUTR, V5, DOI 10.3389/fnut.2018.00122
   Ridker PM, 2016, CIRC RES, V118, P145, DOI 10.1161/CIRCRESAHA.115.306656
   Ried K, 2016, INTEGR BLOOD PRESS C, V9, P9, DOI 10.2147/IBPC.S93335
   Tosi MER, 2011, CELL STRESS CHAPERON, V16, P57, DOI 10.1007/s12192-010-0221-y
   Ritchie SA, 2007, NUTR METAB CARDIOVAS, V17, P319, DOI 10.1016/j.numecd.2006.07.005
   Rodrigues C, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020295
   Ryu JH, 2017, MOLECULES, V22, DOI 10.3390/molecules22060919
   Santhosha SG, 2013, FOOD BIOSCI, V3, P59, DOI 10.1016/j.fbio.2013.07.001
   Schwingshackl L, 2016, PHYTOMEDICINE, V23, P1127, DOI 10.1016/j.phymed.2015.10.015
   Shang A, 2019, FOODS, V8, DOI 10.3390/foods8070246
   Shin IS, 2013, FOOD CHEM TOXICOL, V62, P506, DOI 10.1016/j.fct.2013.09.012
   Sultana MR, 2016, LIFE SCI, V164, P42, DOI 10.1016/j.lfs.2016.08.030
   Szulinska M, 2018, BIOMED PHARMACOTHER, V102, P792, DOI 10.1016/j.biopha.2018.03.131
   Taleb S, 2016, ARCH CARDIOVASC DIS, V109, P708, DOI 10.1016/j.acvd.2016.04.002
   Tilli CMLJ, 2003, ARCH DERMATOL RES, V295, P117, DOI 10.1007/s00403-003-0404-9
   Torres-Palazzolo C, 2018, J FOOD COMPOS ANAL, V70, P49, DOI 10.1016/j.jfca.2018.03.008
   van Rooy MJ, 2014, CURR MED CHEM, V21, P2121
   Varshney R, 2016, J NUTR, V146, p416S, DOI 10.3945/jn.114.202333
   Wan QY, 2019, FOOD SCI NUTR, V7, P2451, DOI 10.1002/fsn3.1117
   Wang SY, 2016, MOL MED REP, V14, P3086, DOI 10.3892/mmr.2016.5651
   Wong BW, 2012, CAN J CARDIOL, V28, P631, DOI 10.1016/j.cjca.2012.06.023
   Xu CJ, 2018, CLIN NUTR ESPEN, V24, P148, DOI 10.1016/j.clnesp.2017.11.010
   Yazici D, 2017, ADV EXP MED BIOL, V960, P277, DOI 10.1007/978-3-319-48382-5_12
   Yuan YJ, 2016, MECH AGEING DEV, V155, P10, DOI 10.1016/j.mad.2016.02.003
   Zare E, 2019, BMC NEPHROL, V20, DOI 10.1186/s12882-019-1204-6
   Zeb I, 2018, CORONARY ARTERY DIS, V29, P325, DOI 10.1097/MCA.0000000000000587
   Zhai BQ, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-21421-x
   Zhang Lei, 2019, Subcell Biochem, V91, P227, DOI 10.1007/978-981-13-3681-2_9
   Zhang M, 2017, CELL PHYSIOL BIOCHEM, V41, P2255, DOI 10.1159/000475640
   Zhang YM, 2019, J ETHNOPHARMACOL, V231, P486, DOI 10.1016/j.jep.2018.11.030
   Zhu YQ, 2018, NEUROL RES, V40, P421, DOI 10.1080/01616412.2018.1451269
   Zuniga KE, 2019, BREAST CANCER RES TR, V173, P145, DOI 10.1007/s10549-018-4982-9
NR 96
TC 45
Z9 46
U1 0
U2 14
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD JAN 10
PY 2020
VL 22
IS 1
AR 6
DI 10.1007/s11906-019-1009-9
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA KO2QS
UT WOS:000515394900002
PM 31925548
DA 2025-06-11
ER

PT J
AU Mazzola, D
   Fornari, F
   Vigano, G
   Oro, T
   Costa, JAV
   Bertolin, TE
AF Mazzola, Daiane
   Fornari, Fernando
   Vigano, Gabriela
   Oro, Tatiana
   Vieira Costa, Jorge Alberto
   Bertolin, Telma Elita
TI Spirulina platensis Enhances the Beneficial Effect of Exercise on
   Oxidative Stress and the Lipid Profile in Rats
SO BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY
LA English
DT Article
DE Exercise; antioxidant; cholesterol; lipid peroxidation
ID ANTIOXIDANT; SUPPLEMENTATION; DAMAGE; ATHEROSCLEROSIS; PEROXIDATION;
   DYSFUNCTION; METABOLISM; MECHANISMS; ENDURANCE; TOXICITY
AB This study aimed to evaluate the effect of Spirulina platensis and moderate exercise on oxidative stress and lipid profiles in the rats. Forty male Wistar rats were allocated to the following 10-week treatments, three times a week: exercise (E, 30 min swimming), S. platensis (SP, 26 mg/Kg); exercise and Spirulina (ES); and control (C). Outcomes were Thiobarbituric Acid Reactive Substances (TBARS) in serum and brain, and cholesterol and triglycerides (TG) in serum. Rats treated with exercise showed lower brain TBARS than the controls, mostly in association with S. platensis. In the groups E and ES, serum TBARS decreased after intervention. Compared with the controls, both E and ES prevented an increase in cholesterol and reduced triglycerides. Results demonstrated that S. platensis enhanced the beneficial effect of exercise on oxidative stress and lipid profiles in rats, which might be a promising approach for treating metabolic syndrome in humans.
C1 [Mazzola, Daiane; Vigano, Gabriela; Oro, Tatiana; Bertolin, Telma Elita] Univ Passo Fundo, Inst Ciencias Biol, Lab Tecnol Fermentacoes, Passo Fundo, RS, Brazil.
   [Fornari, Fernando] Univ Passo Fundo, Fac Med, Passo Fundo, RS, Brazil.
   [Vieira Costa, Jorge Alberto] Univ Fed Rio Grande, Fac Quim & Engn Alimentos, Rio Grande, RS, Brazil.
C3 Universidade de Passo Fundo; Universidade de Passo Fundo; Universidade
   Federal do Rio Grande
RP Bertolin, TE (corresponding author), Univ Passo Fundo, Inst Ciencias Biol, Lab Tecnol Fermentacoes, Passo Fundo, RS, Brazil.
EM telma@upf.br
RI Fornari, Fernando/GOJ-7615-2022; Bertolin, Telma/AAG-8473-2021; Costa,
   Jorge Alberto Vieira/L-3999-2013; ORO, TATIANA/H-2801-2014
OI Fornari, Fernando/0000-0003-0899-329X; Costa, Jorge Alberto
   Vieira/0000-0001-8042-7642; ORO, TATIANA/0000-0002-8415-1863
FU CNPq; PPGEH
FX The authors would like to thank the Instituto de Ciencias Biologicas -
   UPF - which provided the location and facilities to perform the
   experimental work. This work was supported by grants from CNPq and
   PPGEH.
CR Adibhatla Rao Muralikrishna, 2008, V49, P241, DOI 10.1007/978-1-4020-8831-5_9
   Akao Y, 2009, CANCER SCI, V100, P1494, DOI 10.1111/j.1349-7006.2009.01188.x
   ANVISA - Agencia Nacional de Vigilancia Sanitaria, 2009, 7 LIST NOV INGR APR
   Babusikova E, 2007, NEUROCHEM RES, V32, P1351, DOI 10.1007/s11064-007-9314-0
   Bermejo-Bescós P, 2008, TOXICOL IN VITRO, V22, P1496, DOI 10.1016/j.tiv.2008.05.004
   Bertolin TE, 2009, BRAZ ARCH BIOL TECHN, V52, P1253, DOI 10.1590/S1516-89132009000500024
   Blagosklonny MV, 2010, AGING-US, V2, P177, DOI 10.18632/aging.100139
   Çakir B, 2010, CELL BIOCHEM FUNCT, V28, P469, DOI 10.1002/cbf.1679
   Cheong SH, 2010, J NUTR SCI VITAMINOL, V56, P34, DOI 10.3177/jnsv.56.34
   Farooq S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0108713
   FIOCRUZ - Fundacao Oswaldo Cruz, 1994, MAN TECN AN LAB CAP
   Gamba P, 2015, FRONT AGING NEUROSCI, V7, DOI 10.3389/fnagi.2015.00119
   Gomez-Cabrera MC, 2008, FREE RADICAL BIO MED, V44, P126, DOI 10.1016/j.freeradbiomed.2007.02.001
   Gomez-Pinilla F, 2011, PREV MED, V52, pS75, DOI 10.1016/j.ypmed.2011.01.023
   Gustaw-Rothenberg K, 2010, GERIATR GERONTOL INT, V10, P161, DOI 10.1111/j.1447-0594.2009.00571.x
   Hare DJ, 2015, NAT REV NEUROL, V11, P536, DOI 10.1038/nrneurol.2015.100
   Hwang JH, 2011, J NUTR SCI VITAMINOL, V57, P186, DOI 10.3177/jnsv.57.186
   Kalafati M, 2010, MED SCI SPORT EXER, V42, P142, DOI 10.1249/MSS.0b013e3181ac7a45
   Khan Z, 2005, CURR PHARM BIOTECHNO, V6, P373, DOI 10.2174/138920105774370607
   Kim E, 2004, J NUTR SCI VITAMINOL, V50, P335, DOI 10.3177/jnsv.50.335
   Kim W-Y., 2003, KOREAN J NUTR, V36, P287
   Macedo D, 2015, HUM MOL GENET, V24, P1717, DOI 10.1093/hmg/ddu585
   Meilhac O, 2001, ARTERIOSCL THROM VAS, V21, P1681, DOI 10.1161/hq1001.097106
   NAKAYA N, 1988, NUTR REP INT, V37, P1329
   Navarro A, 2010, FRONT AGING NEUROSCI, V2, DOI 10.3389/fnagi.2010.00034
   Negre-Salvayre A, 2010, FREE RADICAL RES, V44, P1125, DOI 10.3109/10715762.2010.498478
   Onat A, 2012, TURK KARDIYOL DERN A, V40, P368, DOI 10.5543/tkda.2012.55490
   Pabon MM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0045256
   Potter TM, 2011, METHODS MOL BIOL, V697, P181, DOI 10.1007/978-1-60327-198-1_19
   Quiles JL, 2003, NUTRITION, V19, P363, DOI 10.1016/S0899-9007(02)00949-8
   Quirós PM, 2015, NAT REV MOL CELL BIO, V16, P345, DOI 10.1038/nrm3984
   Ramamoorthy A, 1996, J FOOD SCI TECH MYS, V33, P124
   Sainz N, 2010, MEDIAT INFLAMM, V2010, P784
   Scott CT, 2015, NAT BIOTECHNOL, V33, P31, DOI 10.1038/nbt.3108
   STEELS EL, 1994, MICROBIOL-SGM, V140, P569, DOI 10.1099/00221287-140-3-569
   Ungvari Z, 2010, J GERONTOL A-BIOL, V65, P1028, DOI 10.1093/gerona/glq113
   Vatani DS, 2012, APPETITE, V59, P673, DOI 10.1016/j.appet.2012.08.005
   Vaupel JW, 2010, NATURE, V464, P536, DOI 10.1038/nature08984
   Vaziri ND, 2010, NAT REV NEPHROL, V6, P287, DOI 10.1038/nrneph.2010.36
   Venditti P, 1997, INT J SPORTS MED, V18, P497, DOI 10.1055/s-2007-972671
   Viña J, 2000, IUBMB LIFE, V49, P539
   Wang XK, 2010, FRONT AGING NEUROSCI, V2, DOI 10.3389/fnagi.2010.00012
   Yogianti F, 2014, J INVEST DERMATOL, V134, P2610, DOI 10.1038/jid.2014.188
   Zheng J, 2013, AM J PHYSIOL-REG I, V304, pR110, DOI 10.1152/ajpregu.00648.2011
NR 44
TC 7
Z9 9
U1 1
U2 11
PU INST TECNOLOGIA PARANA
PI CURITIBA-PARANA
PA RUA PROF ALGACYR MUNHOZ MADER 3775-CIC, 81350-010 CURITIBA-PARANA,
   BRAZIL
SN 1516-8913
EI 1678-4324
J9 BRAZ ARCH BIOL TECHN
JI Braz. Arch. Biol. Technol.
PD NOV-DEC
PY 2015
VL 58
IS 6
BP 961
EP 969
DI 10.1590/S1516-89132015060216
PG 9
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA CY2ZT
UT WOS:000366277400019
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Huang, SH
   Chen, SC
   Geng, JH
   Wu, DW
   Li, CH
AF Huang, Szu-Han
   Chen, Szu-Chia
   Geng, Jiun-Hung
   Wu, Da-Wei
   Li, Chien-Hsun
TI Metabolic Syndrome and High-Obesity-Related Indices Are Associated with
   Poor Cognitive Function in a Large Taiwanese Population Study Older than
   60 Years
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; obesity-related indices; Mini-Mental State
   Examination; cognitive impairment
ID LOW BLOOD-PRESSURE; MINI-MENTAL-STATE; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; BRAIN ATROPHY; RISK; DEMENTIA; IMPAIRMENT;
   DEPRESSION; TRIGLYCERIDES
AB Metabolic syndrome (MetS) is prevalent in Taiwan; however, the association between MetS and cognitive function is unclear. The aim of this study was to explore the associations between MetS, its components, and obesity-related indices with cognitive function in a large Taiwanese cohort. We enrolled a total of 28,486 participants who completed the Mini-Mental State Examination (MMSE) questionnaire, which was used to evaluate cognitive function. MetS was defined according to the NCEP-ATP III guidelines and modified criteria for Asians. Ten obesity-related indices were also evaluated: body mass index (BMI), abdominal volume index (AVI), body adiposity index (BAI), waist-hip ratio (WHR), a body shape index (ABSI), lipid accumulation product, waist-to-height ratio (WHtR), conicity index (CI), body roundness index (BRI), and triglyceride glucose index. The prevalence of MetS and its components (except for hypertriglyceridemia) and the number of MetS components increased while the cognitive impairment worsened (from MMSE >= 24, 18-23 to 0-17). In addition, increases in all obesity-related index values were associated with a decline in cognitive function (from MMSE >= 24, 18-23 to 0-17, ANOVA p < 0.001). Multivariable analysis showed that MetS (p = 0.002), abdominal obesity (p < 0.001), low high-density lipoprotein cholesterol (p = 0.004), and hyperglycemia (p = 0.012) were significantly associated with a low MMSE score. Further, participants with high BMI (p = 0.001), WHR (p < 0.001), WHtR (p < 0.001), BRI (p < 0.001), CI (p < 0.001), BAI (p < 0.001), AVI (p < 0.001), and ABSI (p < 0.001) values were significantly associated with a low MMSE score. Our results show that MetS and its components (except for hypertriglyceridemia and high blood pressure) may lead to cognitive impairment, and that high values of obesity-related indices were associated with poor cognitive function.
C1 [Huang, Szu-Han] Kaohsiung Med Univ, Dept Post Baccalaureate Med, Kaohsiung 807, Taiwan.
   [Chen, Szu-Chia; Wu, Da-Wei] Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Dept Internal Med, Kaohsiung 812, Taiwan.
   [Chen, Szu-Chia] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 807, Taiwan.
   [Chen, Szu-Chia] Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 807, Taiwan.
   [Chen, Szu-Chia] Kaohsiung Med Univ, Res Ctr Environm Med, Kaohsiung 807, Taiwan.
   [Geng, Jiun-Hung] Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Dept Urol, Kaohsiung 812, Taiwan.
   [Geng, Jiun-Hung] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Urol, Kaohsiung 807, Taiwan.
   [Wu, Da-Wei] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Pulm & Crit Care Med, Kaohsiung 807, Taiwan.
   [Li, Chien-Hsun] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Neurol, Kaohsiung 807, Taiwan.
   [Li, Chien-Hsun] Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Dept Neurol, Kaohsiung 812, Taiwan.
   [Li, Chien-Hsun] Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Integrated Ctr Hlth & Long Term Care, Kaohsiung 812, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University; Kaohsiung
   Municipal Siao-Gang Hospital; Kaohsiung Medical University; Kaohsiung
   Medical University Hospital; Kaohsiung Medical University; Kaohsiung
   Medical University; Kaohsiung Medical University; Kaohsiung Municipal
   Siao-Gang Hospital; Kaohsiung Medical University; Kaohsiung Medical
   University Hospital; Kaohsiung Medical University; Kaohsiung Medical
   University Hospital; Kaohsiung Medical University; Kaohsiung Medical
   University Hospital; Kaohsiung Medical University; Kaohsiung Municipal
   Siao-Gang Hospital; Kaohsiung Medical University; Kaohsiung Municipal
   Siao-Gang Hospital
RP Li, CH (corresponding author), Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Neurol, Kaohsiung 807, Taiwan.; Li, CH (corresponding author), Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Dept Neurol, Kaohsiung 812, Taiwan.; Li, CH (corresponding author), Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Integrated Ctr Hlth & Long Term Care, Kaohsiung 812, Taiwan.
EM gavin40708123@gmail.com; scarchenone@yahoo.com.tw; u9001090@gmail.com;
   u8900030@yahoo.com.tw; gavli@kmu.edu.tw
RI 蘇, 河名/AAE-9843-2019; GENG, JIUNHUNG/AAB-2322-2022; Wu,
   Da-Wei/AHB-2174-2022
OI Wu, Da-Wei/0000-0001-5737-6613; Chen, Szu-Chia/0000-0002-1610-4184;
   HUANG, SZU-HAN/0000-0002-2425-1002
FU Research Center for Environmental Medicine, Kaohsiung Medical
   University, Kaohsiung, Taiwan, from The Featured Areas Research Center
   Program within Ministry of Education (MOE) in Taiwan; Kaohsiung Medical
   University Research Center Grants [KMU-TC111A01, KMUTC111IFSP01]
FX This work was supported partially by the Research Center for
   Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan,
   from The Featured Areas Research Center Program within the framework of
   the Higher Education Sprout Project by the Ministry of Education (MOE)
   in Taiwan and by Kaohsiung Medical University Research Center Grants
   (KMU-TC111A01 and KMUTC111IFSP01).
CR Akbaraly TN, 2011, DIABETES CARE, V34, P904, DOI 10.2337/dc10-1644
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Apostolatos A, 2012, J BIOL CHEM, V287, P9299, DOI 10.1074/jbc.M111.313080
   Arevalo-Rodriguez I, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD010783.pub2
   Bangen KJ, 2019, J ALZHEIMERS DIS, V71, P931, DOI 10.3233/JAD-190261
   Bergman RN, 2011, OBESITY, V19, P1083, DOI 10.1038/oby.2011.38
   Buyo M, 2020, J NUTR HEALTH AGING, V24, P878, DOI 10.1007/s12603-020-1412-6
   Chakrabarty Trisha, 2016, Focus (Am Psychiatr Publ), V14, P194, DOI 10.1176/appi.focus.20150043
   Chen CH, 2016, HUM MOL GENET, V25, P5321, DOI 10.1093/hmg/ddw346
   Cheng Yan, 2014, Shanghai Arch Psychiatry, V26, P4, DOI 10.3969/j.issn.1002-0829.2014.01.002
   Dik MG, 2007, DIABETES CARE, V30, P2655, DOI 10.2337/dc06-1190
   Dimache AM, 2021, NUTRIENTS, V13, DOI 10.3390/nu13062118
   Dye L, 2017, P NUTR SOC, V76, P443, DOI 10.1017/S0029665117002014
   Fan CT, 2015, J LAW MED ETHICS, V43, P816, DOI 10.1111/jlme.12322
   FOLSTEIN MF, 1975, J PSYCHIAT RES, V12, P189, DOI 10.1016/0022-3956(75)90026-6
   Forti P, 2010, J AM GERIATR SOC, V58, P487, DOI 10.1111/j.1532-5415.2010.02731.x
   Frisardi V, 2014, J ALZHEIMERS DIS, V41, P163, DOI 10.3233/JAD-140389
   Gaspar JM, 2016, ACS CHEM NEUROSCI, V7, P131, DOI 10.1021/acschemneuro.5b00240
   Gheshlagh RG, 2016, IRAN RED CRESCENT ME, V18, DOI 10.5812/ircmj.26523
   Giannopoulos S, 2010, EUR J NEUROL, V17, P1457, DOI 10.1111/j.1468-1331.2010.03087.x
   Guerrero-Romero F, 2003, ARCH MED RES, V34, P428, DOI 10.1016/S0188-4409(03)00073-0
   Guerrero-Romero F, 2010, J CLIN ENDOCR METAB, V95, P3347, DOI 10.1210/jc.2010-0288
   Guo ZC, 1996, BRIT MED J, V312, P805, DOI 10.1136/bmj.312.7034.805
   Hsu YE, 2021, NUTRIENTS, V13, DOI 10.3390/nu13114055
   Isomaa B, 2001, DIABETOLOGIA, V44, P1148, DOI 10.1007/s001250100615
   Jung JY, 2019, ACTA DIABETOL, V56, P551, DOI 10.1007/s00592-019-01290-0
   Kahn Henry S, 2005, BMC Cardiovasc Disord, V5, P26, DOI 10.1186/1471-2261-5-26
   Koivistoinen T, 2011, ANN MED, V43, P312, DOI 10.3109/07853890.2010.549145
   Kooistra M, 2013, J NEUROL SCI, V332, P69, DOI 10.1016/j.jns.2013.06.019
   Krakauer NY, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039504
   Langa KM, 2014, JAMA-J AM MED ASSOC, V312, P2551, DOI 10.1001/jama.2014.13806
   Lazo-Porras M, 2017, BMC GERIATR, V17, DOI 10.1186/s12877-017-0628-8
   Levey AS, 1999, ANN INTERN MED, V130, P461, DOI 10.7326/0003-4819-130-6-199903160-00002
   Lin IT, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18030857
   Martín-Timón I, 2014, WORLD J DIABETES, V5, P444, DOI 10.4239/wjd.v5.i4.444
   Mendrick DL, 2018, TOXICOL SCI, V162, P36, DOI 10.1093/toxsci/kfx233
   Mone P, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10082115
   Mulvahill JS, 2017, J AM GERIATR SOC, V65, P2651, DOI 10.1111/jgs.15129
   Nakabe T, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-026733
   Ou YL, 2021, RENAL FAILURE, V43, P1250, DOI 10.1080/0886022X.2021.1969247
   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
   Patel TP, 2016, HEART FAIL REV, V21, P11, DOI 10.1007/s10741-015-9515-6
   Petersen RC, 1999, ARCH NEUROL-CHICAGO, V56, P303, DOI 10.1001/archneur.56.3.303
   Petersen RC, 2018, NEUROLOGY, V90, P126, DOI 10.1212/WNL.0000000000004826
   Putra S.E., 2021, CALLOSUM NEUROL, V4, P34, DOI [10.29342/cnj.v4i1.135, DOI 10.29342/CNJ.V4I1.135]
   Raffaitin C, 2011, NEUROLOGY, V76, P518, DOI 10.1212/WNL.0b013e31820b7656
   Rock PL, 2014, PSYCHOL MED, V44, P2029, DOI 10.1017/S0033291713002535
   Schaller S, 2015, INT J GERIATR PSYCH, V30, P111, DOI 10.1002/gps.4198
   Sipilä K, 2009, ATHEROSCLEROSIS, V204, P276, DOI 10.1016/j.atherosclerosis.2008.08.029
   Tan CE, 2004, DIABETES CARE, V27, P1182, DOI 10.2337/diacare.27.5.1182
   Thomas DM, 2013, OBESITY, V21, P2264, DOI 10.1002/oby.20408
   Tomás E, 2002, ANN NY ACAD SCI, V967, P43
   TOMBAUGH TN, 1992, J AM GERIATR SOC, V40, P922, DOI 10.1111/j.1532-5415.1992.tb01992.x
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
   VALDEZ R, 1991, J CLIN EPIDEMIOL, V44, P955, DOI 10.1016/0895-4356(91)90059-I
   Verghese J, 2003, NEUROLOGY, V61, P1667, DOI 10.1212/01.WNL.0000098934.18300.BE
   Wang XH, 2021, BMC ENDOCR DISORD, V21, DOI 10.1186/s12902-021-00705-w
   Wisse LEM, 2014, J NEUROL SCI, V344, P32, DOI 10.1016/j.jns.2014.06.008
   Wu LH, 2021, NUTR METAB, V18, DOI 10.1186/s12986-020-00536-x
   Wung CH, 2021, J PERS MED, V11, DOI 10.3390/jpm11080775
   Wung CH, 2021, J PERS MED, V11, DOI 10.3390/jpm11060533
   Xia X, 2021, HYPERTENSION, V78, P769, DOI 10.1161/HYPERTENSIONAHA.121.17454
   Yaffe K, 2007, ALZ DIS ASSOC DIS, V21, P167, DOI 10.1097/WAD.0b013e318065bfd6
   Yates KF, 2012, ARTERIOSCL THROM VAS, V32, P2060, DOI 10.1161/ATVBAHA.112.252759
   Yin ZX, 2012, AGE AGEING, V41, P600, DOI 10.1093/ageing/afs033
NR 65
TC 19
Z9 20
U1 2
U2 22
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2022
VL 14
IS 8
AR 1535
DI 10.3390/nu14081535
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA 0S2SB
UT WOS:000786128200001
PM 35458097
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Song, J
   Huang, YP
   Zheng, WJ
   Yan, J
   Cheng, M
   Zhao, RX
   Chen, L
   Hu, C
   Jia, WP
AF Song, Jun
   Huang, Yeping
   Zheng, Wenjian
   Yan, Jing
   Cheng, Min
   Zhao, Ruxing
   Chen, Li
   Hu, Cheng
   Jia, Weiping
TI Resveratrol reduces intracellular reactive oxygen species levels by
   inducing autophagy through the AMPK-mTOR pathway
SO FRONTIERS OF MEDICINE
LA English
DT Article
DE resveratrol; reactive oxygen species; AMPK; mTOR; autophagy
ID OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; CELLS; MECHANISMS;
   PHOSPHORYLATION
AB Oxidative stress induced by free fatty acid aggravates endothelial injury, which leads to diabetic cardiovascular complications. Reduction of intracellular oxidative stress may attenuate these pathogenic processes. The dietary polyphenol resveratrol reportedly exerts potential protective effects against endothelial injury. This study determined whether resveratrol can reduce the palmitic acid (PA)-induced generation of reactive oxygen species (ROS) and further explored the underlying molecular mechanisms. We found that resveratrol significantly reduced the PA-induced endothelial ROS levels in human aortic endothelial cells. Resveratrol also induced endothelial cell autophagy, which mediated the effect of resveratrol on ROS reduction. Resveratrol stimulated autophagy via the AMP-activated protein kinase (AMPK)-mTOR pathway. Taken together, these data suggest that resveratrol prevents PA-induced intracellular ROS by autophagy regulation via the AMPK-mTOR pathway. Thus, the induction of autophagy by resveratrol may provide a novel therapeutic candidate for cardioprotection in metabolic syndrome.
C1 [Song, Jun; Huang, Yeping; Yan, Jing; Hu, Cheng; Jia, Weiping] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai Key Clin Ctr Metab Dis, Shanghai Diabet Inst,Shanghai Key Lab Diabet Mell, Shanghai 200233, Peoples R China.
   [Song, Jun; Zhao, Ruxing; Chen, Li] Shandong Univ, Dept Endocrinol, Qilu Hosp, Jinan 250012, Shandong, Peoples R China.
   [Song, Jun] Tongji Univ, Sch Med, Shanghai East Hosp, Dept Endocrinol, Shanghai 200120, Peoples R China.
   [Zheng, Wenjian] Qingdao Haici Med Treatment Grp, Dept Geriatr, Qingdao 266000, Peoples R China.
   [Cheng, Min] Huangdao Dis Prevent & Control Ctr, Qingdao 266555, Peoples R China.
C3 Shanghai Jiao Tong University; Shandong University; Tongji University
RP Hu, C; Jia, WP (corresponding author), Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai Key Clin Ctr Metab Dis, Shanghai Diabet Inst,Shanghai Key Lab Diabet Mell, Shanghai 200233, Peoples R China.
EM alfredhc@sjtu.edu.cn; wpjia@sjtu.edu.cn
RI Jia, Weiping/B-7483-2012; Hu, Cheng/C-3346-2008
OI Jia, Weiping/0000-0002-6244-2168; Hu, Cheng/0000-0003-4314-2386
FU outstanding young scientist research grant in Shandong Province
   [2013BSE27128]; National Natural Science Foundation of China [81370943];
   China Postdoctoral Science Foundation [2015M580334]; Shanghai Municipal
   Health and Family Planning Commission Project [20134189]
FX The present work was funded by outstanding young scientist research
   grant in Shandong Province (No. 2013BSE27128), National Natural Science
   Foundation of China (No. 81370943), China Postdoctoral Science
   Foundation (No. 2015M580334) and Shanghai Municipal Health and Family
   Planning Commission Project (No. 20134189).
CR Antonioli M, 2017, TRENDS BIOCHEM SCI, V42, P28, DOI 10.1016/j.tibs.2016.09.008
   Baxter Richard A, 2008, J Cosmet Dermatol, V7, P2, DOI 10.1111/j.1473-2165.2008.00354.x
   Bonnefont-Rousselot D, 2016, NUTRIENTS, V8, DOI 10.3390/nu8050250
   Bradamante S, 2004, CARDIOVASC DRUG REV, V22, P169
   Carrizzo A, 2013, FOOD CHEM TOXICOL, V61, P215, DOI 10.1016/j.fct.2013.07.021
   Elnakish MT, 2013, J PATHOL, V231, P290, DOI 10.1002/path.4255
   Fan XD, 2015, J TRANSL MED, V13, DOI 10.1186/s12967-015-0450-z
   Gu J, 2016, INT IMMUNOPHARMACOL, V32, P1, DOI 10.1016/j.intimp.2016.01.002
   Gwinn DM, 2008, MOL CELL, V30, P214, DOI 10.1016/j.molcel.2008.03.003
   Han SY, 2015, AM J CHINESE MED, V43, P1605, DOI 10.1142/S0192415X15500913
   Hao HD, 2004, J MED FOOD, V7, P290, DOI 10.1089/jmf.2004.7.290
   He CY, 2015, DIABETES, V64, P4285, DOI 10.2337/db15-0107
   Hutcheson R, 2012, EXP DIABETES RES, DOI 10.1155/2012/271028
   Incalza MA, 2018, VASC PHARMACOL, V100, P1, DOI 10.1016/j.vph.2017.05.005
   Jo HK, 2014, BIOL PHARM BULL, V37, P1341, DOI 10.1248/bpb.b14-00281
   Kiffin R, 2006, ANTIOXID REDOX SIGN, V8, P152, DOI 10.1089/ars.2006.8.152
   Klionsky DJ, 2016, AUTOPHAGY, V12, P1, DOI 10.1080/15548627.2015.1100356
   Koshkin V, 2003, J BIOL CHEM, V278, P19709, DOI 10.1074/jbc.M209709200
   Lee Y, 2012, J CARDIOVASC PHARM, V60, P118, DOI 10.1097/FJC.0b013e318256cdd0
   Li XN, 2009, DIABETES, V58, P2246, DOI 10.2337/db08-1512
   Morales CR, 2014, ANTIOXID REDOX SIGN, V20, P507, DOI 10.1089/ars.2013.5359
   Nagata D, 2003, J BIOL CHEM, V278, P31000, DOI 10.1074/jbc.M300643200
   Novelle MG, 2015, AGEING RES REV, V21, P1, DOI 10.1016/j.arr.2015.01.002
   Saad MI, 2015, ENDOCRINE, V50, P537, DOI 10.1007/s12020-015-0709-4
   Diaz-Gerevini GT, 2016, NUTRITION, V32, P174, DOI 10.1016/j.nut.2015.08.017
   Wu SB, 2014, BBA-GEN SUBJECTS, V1840, P1331, DOI 10.1016/j.bbagen.2013.10.034
   Xia N, 2014, MOLECULES, V19, P16102, DOI 10.3390/molecules191016102
   Xu M, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/7453849
   Youn JY, 2009, CIRC RES, V104, P50, DOI 10.1161/CIRCRESAHA.108.178467
   Zhang LS, 2017, ENVIRON POLLUT, V220, P843, DOI 10.1016/j.envpol.2016.10.067
   Zheng XT, 2017, MOL CELL BIOCHEM, V425, P125, DOI 10.1007/s11010-016-2868-x
   Zou MH, 2002, J BIOL CHEM, V277, P32552, DOI 10.1074/jbc.M204512200
NR 32
TC 50
Z9 56
U1 3
U2 45
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 2095-0217
EI 2095-0225
J9 FRONT MED-PRC
JI Front. Med.
PD DEC
PY 2018
VL 12
IS 6
BP 697
EP 706
DI 10.1007/s11684-018-0655-7
PG 10
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA HE4PL
UT WOS:000453348800010
PM 30421395
DA 2025-06-11
ER

PT J
AU Xiong, Y
   Zhang, FX
   Wu, CJ
   Zhang, YC
   Huang, XYZ
   Qin, F
   Yuan, JH
AF Xiong, Yang
   Zhang, Fuxun
   Wu, Changjing
   Zhang, Yangchang
   Huang, Xiaoyingzi
   Qin, Feng
   Yuan, Jiuhong
TI The Circadian Syndrome Predicts Lower Urinary Tract Symptoms Suggestive
   of Benign Prostatic Hyperplasia Better Than Metabolic Syndrome in Aging
   Males: A 4-Year Follow-Up Study
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE aging males; benign prostatic hyperplasia; circadian syndrome; lower
   urinary tract symptoms; metabolic syndrome
ID TESTOSTERONE
AB Background: The prevalence of lower urinary tract symptoms (LUTS) suggestive of benign prostate hyperplasia (BPH) increases in men. Although several risk factors, including metabolic syndrome (MetS) and depression, were identified, the underlying etiological factor remains unclear. Recently, circadian syndrome (CircS) was proposed as a novel risk cluster based on MetS. To compare the predictive power of the CircS and MetS for LUTS/BPH, this study was performed.
   Materials and Methods: In the baseline survey, 4,390 men older than 40 years from the China Health and Retirement Longitudinal Study were enrolled. Of them, 3,658 men were followed in the 2015 survey. Logistic regression was adopted to examine the relationships between CircS, MetS, and LUTS/BPH. To further verify the association, propensity score matching was used for sensitivity analyses. Moreover, the participants who had LUTS/BPH at the baseline were excluded to test the longitudinal relationships between CircS, MetS, and LUTS/BPH. In addition, we employed the receiver operating characteristic (ROC) curve analysis to compare the predictive power using the number of components of CircS and MetS. The DeLong test was used to test the disparities of area under the curves (AUCs).
   Results: The prevalence of CircS and MetS in aging men was 30.23 and 38.36%, respectively. The odds ratios for prevalent LUTS/BPH were 1.61 (95% CI = 1.29-2.00, P < 0.001) and 1.34 (95% CI = 1.08-1.66, P < 0.01), respectively, in aging men. This increased risk was also observed in incident LUTS/BPH. The prevalence of LUTS/BPH in normal, CircS alone, MetS alone, and both CircS and MetS groups was 6.96, 8.77, 7.83, and 10.77%, respectively. The AUCs for CircS predicting prevalent and incident LUTS/BPH were higher than those for MetS (0.582 vs. 0.556 for incident LUTS/BPH, P < 0.001; 0.574 vs. 0.561 for prevalent LUTS/BPH, P < 0.05).
   Conclusions: The CircS predicts both incident and prevalent LUTS/BPH better than MetS.
C1 [Xiong, Yang; Zhang, Fuxun; Wu, Changjing; Huang, Xiaoyingzi; Qin, Feng; Yuan, Jiuhong] Sichuan Univ, West China Hosp, Androl Lab, Chengdu, Peoples R China.
   [Xiong, Yang; Zhang, Fuxun; Yuan, Jiuhong] Sichuan Univ, West China Hosp, Dept Urol, Chengdu, Peoples R China.
   [Zhang, Yangchang] Chongqing Med Univ, Sch Publ Hlth & Management, Dept Epidemiol & Hlth Stat, Chongqing, Peoples R China.
C3 Sichuan University; Sichuan University; Chongqing Medical University
RP Yuan, JH (corresponding author), Sichuan Univ, West China Hosp, Androl Lab, Chengdu, Peoples R China.; Yuan, JH (corresponding author), Sichuan Univ, West China Hosp, Dept Urol, Chengdu, Peoples R China.
EM jiuhongyuan2107@163.com
RI Qin, Feng/JWP-5386-2024; Yang, Xiong/AGP-5601-2022
OI Yuan, Jiuhong/0000-0002-0991-1463; Xiong, Yang/0000-0003-3901-2394; Qin,
   Feng/0000-0001-9521-7146
FU Natural Science Foundation of China [81871147, 82071639]; Chengdu
   Science and Technology Program [2019-YFYF-00087-SN]
FX Funding This work was supported by the Natural Science Foundation of
   China (81871147 and 82071639) and the Chengdu Science and Technology
   Program (2019-YFYF-00087-SN).
CR Allada R, 2021, NEW ENGL J MED, V384, P550, DOI 10.1056/NEJMra1802337
   ANDRESEN EM, 1994, AM J PREV MED, V10, P77, DOI 10.1016/S0749-3797(18)30622-6
   Cakir OO, 2012, CURR UROL REP, V13, P407, DOI 10.1007/s11934-012-0281-x
   Chughtai B, 2016, NAT REV DIS PRIMERS, V2, DOI 10.1038/nrdp.2016.31
   De Nunzio C, 2018, PROSTATE CANCER P D, V21, P287, DOI 10.1038/s41391-017-0003-z
   De Nunzio C, 2016, NAT REV UROL, V13, P613, DOI 10.1038/nrurol.2016.168
   Foster HE, 2018, J UROLOGY, V200, P612, DOI 10.1016/j.juro.2018.05.048
   Ge HS, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-77184-x
   Gratzke C, 2015, EUR UROL, V67, P1099, DOI 10.1016/j.eururo.2014.12.038
   Kaplan SA, 2013, AGING MALE, V16, P169, DOI 10.3109/13685538.2013.844786
   Kawamura M, 2014, ANDROLOGY-US, V2, P225, DOI 10.1111/j.2047-2927.2013.00161.x
   Li YZ, 2019, AGING-US, V11, P5570, DOI 10.18632/aging.102138
   Madersbacher S, 2019, GERONTOLOGY, V65, P458, DOI 10.1159/000496289
   Pietrzyk B, 2015, INT UROL NEPHROL, V47, P431, DOI 10.1007/s11255-015-0920-5
   Roehrborn CG, 2008, INT J IMPOT RES, V20, pS11, DOI 10.1038/ijir.2008.55
   Sebastianelli A, 2018, EUR UROL FOCUS, V4, P25, DOI 10.1016/j.euf.2018.03.007
   Shi Z, 2021, J INTERN MED, V289, P851, DOI 10.1111/joim.13204
   Sokka T, 2008, CLIN EXP RHEUMATOL, V26, pS35, DOI 10.1161/CIRCULATIONAHA.109.192644
   Vignozzi L, 2016, NAT REV UROL, V13, P108, DOI 10.1038/nrurol.2015.301
   Wendeu-Foyet MG, 2020, INT J CANCER, V147, P3119, DOI 10.1002/ijc.33139
   Xiong Y, 2021, ASIAN J ANDROL, V23, P633, DOI 10.4103/aja.aja_12_21
   Xiong Y, 2021, TRANSL ANDROL UROL, V10, DOI 10.21037/tau-20-1127
   Xiong Y, 2020, AGING MALE, V23, P1432, DOI 10.1080/13685538.2020.1781806
   Yoo S, 2019, BJU INT, V123, P140, DOI 10.1111/bju.14528
   Zhang WY, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-022792
   Zhao YH, 2014, INT J EPIDEMIOL, V43, P61, DOI 10.1093/ije/dys203
   Zimmet P, 2019, J INTERN MED, V286, P181, DOI 10.1111/joim.12924
NR 27
TC 23
Z9 23
U1 0
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD SEP 21
PY 2021
VL 8
AR 715830
DI 10.3389/fmed.2021.715830
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA WB3TB
UT WOS:000703497000001
PM 34621761
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Agarwal, AK
AF Agarwal, AK
TI Cortisol metabolism and visceral obesity:: Role of 11β-hydroxysteroid
   dehydrogenase type I enzyme and reduced co-factor NADPH
SO ENDOCRINE RESEARCH
LA English
DT Article
DE 11 beta-HSD; co-factor NADPH; visceral obesity; cortisone reductase
   deficiency; G6PDH; H6PDH
ID ADIPOSE-TISSUE; EXPRESSION; GENE; RECEPTOR; CLONING; STRESS; G6PD; CDNA;
   MICE
AB Several factors including genetic and environmental play a role in the development of obesity and the metabolic syndrome. The transgenic mouse overexpressing 11beta-hydroxysteroid dehydrogenase (11beta-HSD) develops visceral obesity. However, it remains unclear how a ubiquitously expressed 11beta-HSD1 enzyme affects adipose tissue so much that it would lead to obesity. In this commentary we explore the possibility that increased intracellular availability of reduced co-factor, NADPH, could exacerbate the enzymatic activity.
C1 Univ Texas, SW Med Ctr, Div Nutr & Metab Dis, Dept Internal Med, Dallas, TX 75390 USA.
   Univ Texas, SW Med Ctr, Ctr Human Nutr, Dallas, TX 75390 USA.
C3 University of Texas System; University of Texas Dallas; University of
   Texas Southwestern Medical Center Dallas; University of Texas System;
   University of Texas Dallas; University of Texas Southwestern Medical
   Center Dallas
RP Agarwal, AK (corresponding author), Univ Texas, SW Med Ctr, Div Nutr & Metab Dis, Dept Internal Med, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.
CR ABATE N, 1995, PROG LIPID RES, V34, P53, DOI 10.1016/0163-7827(94)00006-8
   AGARWAL AK, 1994, J BIOL CHEM, V269, P25959
   AGARWAL AK, 1990, MOL ENDOCRINOL, V4, P1827, DOI 10.1210/mend-4-12-1827
   AGARWAL AK, 1989, J BIOL CHEM, V264, P18939
   Alberts P, 2002, DIABETOLOGIA, V45, P1528, DOI 10.1007/s00125-002-0959-6
   Berger J, 2001, J BIOL CHEM, V276, P12629, DOI 10.1074/jbc.M003592200
   Bujalska IJ, 1997, LANCET, V349, P1210, DOI 10.1016/S0140-6736(96)11222-8
   Draper N, 2003, NAT GENET, V34, P434, DOI 10.1038/ng1214
   Draper N, 2002, J CLIN ENDOCR METAB, V87, P4984, DOI 10.1210/jc.2001-011375
   Eto K, 1999, SCIENCE, V283, P981, DOI 10.1126/science.283.5404.981
   Gelernter-Yaniv L, 2003, INT J OBESITY, V27, P983, DOI 10.1038/sj.ijo.0802327
   GROMNICKI AR, 1991, BIOCHEM GENET, V29, P145
   Kotelevtsev Y, 1997, P NATL ACAD SCI USA, V94, P14924, DOI 10.1073/pnas.94.26.14924
   Mason PJ, 1999, BLOOD CELL MOL DIS, V25, P30, DOI 10.1006/bcmd.1999.0224
   Masuzaki H, 2001, SCIENCE, V294, P2166, DOI 10.1126/science.1066285
   PANDOLFI PP, 1995, EMBO J, V14, P5209, DOI 10.1002/j.1460-2075.1995.tb00205.x
   Salati LM, 2001, ANNU REV NUTR, V21, P121, DOI 10.1146/annurev.nutr.21.1.121
   Simoncini T, 2000, NATURE, V407, P538, DOI 10.1038/35035131
   STRYER L, 1989, BIOCHEMISTRY-US, P427
   Stulnig TM, 2002, DIABETES, V51, P2426, DOI 10.2337/diabetes.51.8.2426
   Tanahashi T, 2002, J STEROID BIOCHEM, V80, P441, DOI 10.1016/S0960-0760(02)00033-X
   Tishkoff SA, 2001, SCIENCE, V293, P455, DOI 10.1126/science.1061573
   Tomlinson JW, 2001, ENDOCRINOLOGY, V142, P1982, DOI 10.1210/en.142.5.1982
   Tomlinson JW, 2002, J CLIN ENDOCR METAB, V87, P5630, DOI 10.1210/jc.2002-020687
   White PC, 1997, ENDOCR REV, V18, P135, DOI 10.1210/er.18.1.135
NR 25
TC 15
Z9 27
U1 0
U2 3
PU MARCEL DEKKER INC
PI NEW YORK
PA 270 MADISON AVE, NEW YORK, NY 10016 USA
SN 0743-5800
J9 ENDOCR RES
JI Endocr. Res.
PY 2003
VL 29
IS 4
BP 411
EP 418
DI 10.1081/ERC-120026947
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 752LX
UT WOS:000187163300005
PM 14682470
DA 2025-06-11
ER

PT J
AU Hayeems, RZ
   Miller, FA
   Barg, CJ
   Bombard, Y
   Carroll, JC
   Tam, K
   Kerr, E
   Chakraborty, P
   Potter, BK
   Patton, S
   Bytautas, JP
   Taylor, L
   Davies, C
   Milburn, J
   Price, A
   Gonska, T
   Keenan, K
   Ratjen, F
   Guttmann, A
AF Hayeems, Robin Z.
   Miller, Fiona A.
   Barg, Carolyn J.
   Bombard, Yvonne
   Carroll, June C.
   Tam, Karen
   Kerr, Elizabeth
   Chakraborty, Pranesh
   Potter, Beth K.
   Patton, Sarah
   Bytautas, Jessica P.
   Taylor, Louise
   Davies, Christine
   Milburn, Jennifer
   Price, April
   Gonska, Tanja
   Keenan, Katherine
   Ratjen, Felix
   Guttmann, Astrid
TI Psychosocial Response to Uncertain Newborn Screening Results for Cystic
   Fibrosis
SO JOURNAL OF PEDIATRICS
LA English
DT Article
ID METABOLIC SYNDROME; DIAGNOSIS; CHILD; PERCEPTIONS; GUIDELINES;
   MANAGEMENT; DISORDERS; KNOWLEDGE; INFANTS; PARENTS
AB Objective To explore the psychosocial implications of diagnostic uncertainty that result from inconclusive results generated by newborn bloodspot screening (NBS) for cystic fibrosis (CF).
   Study design Using a mixed methods prospective cohort study of children who received NBS for CF, we compared psychosocial outcomes of parents whose children who received persistently inconclusive results with those whose children received true positive or screen-negative results.
   Results Mothers of infants who received inconclusive results (n = 17), diagnoses of CF (n = 15), and screen-negative results (n = 411) were surveyed; 23 parent interviews were completed. Compared with mothers of infants with true positive/screen-negative results, mothers of infants with inconclusive results reported greater perceived uncertainty (P < .006) but no differences in anxiety or vulnerability (P > .05). Qualitatively, parents valued being connected to experts but struggled with the meaning of an uncertain diagnosis, worried about their infant's health-related vulnerability, and had mixed views about surveillance.
   Conclusion Inconclusive CF NBS results were not associated with anxiety or vulnerability but led to health-related uncertainty and qualitative concerns. Findings should be considered alongside efforts to optimize protocols for CF screening and surveillance. Educational and psychosocial supports are warranted for these families.
C1 [Hayeems, Robin Z.; Guttmann, Astrid] Hosp Sick Children, Child Hlth Evaluat Sci, Res Inst, Toronto, ON, Canada.
   [Hayeems, Robin Z.; Miller, Fiona A.; Barg, Carolyn J.; Bombard, Yvonne; Patton, Sarah; Bytautas, Jessica P.; Guttmann, Astrid] Univ Toronto, Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada.
   [Bombard, Yvonne] St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada.
   [Carroll, June C.] Univ Toronto, Mt Sinai Hosp, Dept Family & Community Med, Sinai Hlth Syst, Toronto, ON, Canada.
   [Tam, Karen] Hosp Sick Children, Dept Pediat, Div Clin & Metab Genet, Toronto, ON, Canada.
   [Kerr, Elizabeth] Hosp Sick Children, Dept Psychol, Toronto, ON, Canada.
   [Kerr, Elizabeth; Ratjen, Felix; Guttmann, Astrid] Univ Toronto, Dept Pediat, Fac Med, Toronto, ON, Canada.
   [Chakraborty, Pranesh; Davies, Christine; Milburn, Jennifer] Childrens Hosp Eastern Ontario, Newborn Screening Ontario, Ottawa, ON, Canada.
   [Chakraborty, Pranesh] Univ Ottawa, Fac Med, Dept Pediat, Ottawa, ON, Canada.
   [Potter, Beth K.] Univ Ottawa, Fac Med, Sch Epidemiol Publ Hlth & Prevent Med, Ottawa, ON, Canada.
   [Bytautas, Jessica P.] Univ Helsinki, Dept Publ Hlth, Helsinki, Finland.
   [Taylor, Louise; Keenan, Katherine; Guttmann, Astrid] Hosp Sick Children, Dept Pediat, Toronto, ON, Canada.
   [Price, April] Childrens Hosp Western Ontario, Dept Pediat Respirol, London, ON, Canada.
   [Gonska, Tanja] Hosp Sick Children, Div Gastroenterol, Dept Pediat, Toronto, ON, Canada.
   [Gonska, Tanja] Hosp Sick Children, Res Inst, Physiol & Expt Med, Toronto, ON, Canada.
   [Ratjen, Felix] Hosp Sick Children, Dept Pediat, Div Resp Med, Toronto, ON, Canada.
   [Guttmann, Astrid] Inst Clin Evaluat Sci, Hlth Syst Planning & Evaluat Res Program, Toronto, ON, Canada.
C3 University of Toronto; Hospital for Sick Children (SickKids); University
   of Toronto; University of Toronto; Saint Michaels Hospital Toronto; Li
   Ka Shing Knowledge Institute; University of Toronto; Sinai Health System
   Toronto; University of Toronto; Hospital for Sick Children (SickKids);
   University of Toronto; Hospital for Sick Children (SickKids); University
   of Toronto; University of Ottawa; Children's Hospital of Eastern
   Ontario; University of Ottawa; University of Ottawa; University of
   Helsinki; University of Toronto; Hospital for Sick Children (SickKids);
   Western University (University of Western Ontario); University Western
   Ontario Hospital; University of Toronto; Hospital for Sick Children
   (SickKids); University of Toronto; Hospital for Sick Children
   (SickKids); University of Toronto; Hospital for Sick Children
   (SickKids); University of Toronto; Institute for Clinical Evaluative
   Sciences (ICES)
RP Hayeems, RZ (corresponding author), Hosp Sick Children, Res Inst, 686 Bay St,11-9710, Toronto, ON M5G 0A4, Canada.
EM robin.hayeems@sickkids.ca
RI Carroll, June/K-2096-2017; Bytautas, Jessica/F-3066-2016
OI Bytautas, Jessica/0000-0002-7931-2036; Miller,
   Fiona/0000-0003-4953-6255; Ratjen, Felix/0000-0003-4057-6592; Hayeems,
   Robin/0000-0003-3269-8004; Price, April/0000-0001-7994-8715
FU Canadian Institutes of Health Research operating grant [106505]
FX Supported by a Canadian Institutes of Health Research operating grant
   (106505). The authors declare no conflicts of interest.
CR Araia MH, 2011, J COMMUN GENET, V2, P127, DOI 10.1007/s12687-011-0046-0
   Bonham JR, 2013, J INHERIT METAB DIS, V36, P681, DOI 10.1007/s10545-013-9598-y
   Borowitz D, 2009, J PEDIATR-US, V155, pS106, DOI 10.1016/j.jpeds.2009.09.003
   Burke W, 2011, EPIDEMIOL REV, V33, P148, DOI 10.1093/epirev/mxr008
   Dillman D.A., 2009, Internet, Mail, and Mix-Mode Surveys: The Taylored Design Method
   ECFS Neonatal Screening Working Group, MAY 2014 REP
   Farrell PM, 2008, J PEDIATR-US, V153, pS4, DOI 10.1016/j.jpeds.2008.05.005
   Fletcher Janice M, 2008, Ann Acad Med Singap, V37, P27
   Forsyth BWC, 1996, J PEDIATR PSYCHOL, V21, P89, DOI 10.1093/jpepsy/21.1.89
   Goldenberg AJ, 2016, MATERN CHILD HLTH J, V20, P693, DOI 10.1007/s10995-015-1869-9
   Grob R, 2008, SOC SCI MED, V67, P1056, DOI 10.1016/j.socscimed.2008.06.003
   Hayeems RZ, 2016, PEDIATRICS, V138, DOI 10.1542/peds.2016-1052
   Kemper AR, 2005, PUBLIC HEALTH NURS, V22, P332, DOI 10.1111/j.0737-1209.2005.220408.x
   Kerruish NJ, 2008, J MED ETHICS, V34, P648, DOI 10.1136/jme.2007.023374
   Kerruish NJ, 2007, PEDIATRICS, V120, pE324, DOI 10.1542/peds.2006-1381
   Kokotos Faye, 2009, Pediatr Rev, V30, P193, DOI 10.1542/pir.30-5-193
   Koppaka Ram, 2011, Morbidity and Mortality Weekly Report, V60, P619
   Levy H, 2016, CLIN GENET, V89, P539, DOI 10.1111/cge.12711
   Massie J, 2005, PEDIATR PULM, V39, P440, DOI 10.1002/ppul.20191
   Massie J, 2014, PEDIATR PULM, V49, P1, DOI 10.1002/ppul.22933
   Mayell S, 2014, EUR CYST FIBR C 2014
   Miller FA, 2006, PERSPECT BIOL MED, V49, P99, DOI 10.1353/pbm.2006.0012
   Miller FA, 2015, PEDIATRICS, V136, pE413, DOI 10.1542/peds.2015-0518
   MISHEL MH, 1983, NURS RES, V32, P324
   Newborn Screening Ontario, 2013, NEWB SCREEN ONT ANN
   Ooi CY, 2015, PEDIATRICS, V135, pE1377, DOI 10.1542/peds.2014-2081
   Perobelli S, 2009, ACTA PAEDIATR, V98, P1927, DOI 10.1111/j.1651-2227.2009.01485.x
   Potter BK, 2012, J INHERIT METAB DIS, V35, P115, DOI 10.1007/s10545-011-9352-2
   Ren CL, 2011, PEDIATR PULM, V46, P1079, DOI 10.1002/ppul.21475
   Spielberger C., 1983, STAI MANUAL
   Thorne S, 1997, RES NURS HEALTH, V20, P169
   Timmermans S, 2010, J HEALTH SOC BEHAV, V51, P408, DOI 10.1177/0022146510386794
   Tluczek A, 2010, QUAL HEALTH RES, V20, P209, DOI 10.1177/1049732309356285
   van Spronsen FJ, 2011, J INHERIT METAB DIS, V34, P651, DOI 10.1007/s10545-011-9283-y
   Wilcken B, 2010, J INHERIT METAB DIS, V33, pS205, DOI 10.1007/s10545-010-9106-6
NR 35
TC 31
Z9 32
U1 0
U2 4
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
EI 1097-6833
J9 J PEDIATR-US
JI J. Pediatr.
PD MAY
PY 2017
VL 184
BP 165
EP +
DI 10.1016/j.jpeds.2017.01.049
PG 8
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA EU5WH
UT WOS:000401104300033
PM 28279431
DA 2025-06-11
ER

PT J
AU Cosín-Sales, J
   Pizzi, C
   Brown, S
   Kaski, JC
AF Cosín-Sales, J
   Pizzi, C
   Brown, S
   Kaski, JC
TI C-reactive protein, clinical presentation, and ischemic activity in
   patients with chest pain and normal coronary angiograms
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
ID CARDIAC SYNDROME-X; ENDOTHELIAL DYSFUNCTION; MYOCARDIAL-ISCHEMIA;
   ANGINA; ARTERIES; RESISTANCE; DISEASE
AB OBJECTIVES We sought to investigate the relationship among C-reactive protein (hs-CRP), clinical characteristics, exercise stress test responses, and ST-segment changes during daily life in patients with typical chest pain and normal coronary angiograms (CPNCA).
   BACKGROUND Patients with CPNCA have coronary microvascular endothelial dysfunction and myocardial ischemia. Elevated hs-CRP levels have been related to atherogenesis and endothelial dysfunction. The relationship between hs-CRP and disease activity has not been previously investigated in CPNCA patients.
   METHODS We studied 137 consecutive CPNCA patients (mean age, 57 +/- 9; 33 men). All completed standardized angina questionnaires, underwent exercise stress testing, 24-h ambulatory electrocardiogram (ECG) monitoring (Holter), and hs-CRP measurements at study entry.
   RESULTS C-reactive protein levels (mg/l) were higher in patients with frequent (2.9 +/- 3.3) and prolonged (3.9 +/- 4.1) chest pain episodes, and in those with ST-segment depression on exercise testing (2.6 +/- 2.8) and Holter monitoring (3.4 +/- 3.1) compared with patients with occasional (1.3 +/- 1.2; p = 0.002) or shorter chest pain (1.5 +/- 1.3; p < 0.001) episodes, negative exercise stress testing (1.1 +/- 1.1; p < 0.001), and no ST-segment shifts on Holter monitoring (0.9 +/- 0.7; p < 0.001). Moreover, we found a correlation between hs-CRP concentration and number of ischemic episodes during Holter monitoring (r = 0.65; p < 0.001) and with the magnitude of ST-segment depression on exercise testing (r = -0.43; p < 0.001). The hs-CRP was the only independent variable (multivariate logistic regression) capable of predicting positive findings on Holter monitoring (odds ratio [OR], 3.8; confidence interval [CI], 2.3 to 6.2) and exercise testing (OR, 1.7; Cl, 1.2 to 2.2).
   CONCLUSIONS The hs-CRP correlates with symptoms and ECG markers of myocardial ischemia in CPNCA patients. Whether hs-CRP is related to the pathogenesis of angina in these patients deserves further investigation. (C) 2003 by the American College of Cardiology Foundation.
C1 St George Hosp, Sch Med, Dept Cardiol Sci, Coronary Artery Dis Res Unit, London SW17 0RE, England.
C3 City St Georges, University of London
RP St George Hosp, Sch Med, Dept Cardiol Sci, Coronary Artery Dis Res Unit, Cranmer Terrance, London SW17 0RE, England.
EM jkaski@sghms.ac.uk
RI Kaski, Juan Carlos/LKM-8031-2024; PIZZI, Carmine/C-8394-2012
OI Pizzi, Carmine/0000-0002-4048-675X; Cosin-Sales,
   Juan/0000-0002-4249-557X
CR Anzai T, 1997, CIRCULATION, V96, P778
   Bellamy MF, 1998, CARDIOVASC RES, V40, P410, DOI 10.1016/S0008-6363(98)00184-9
   BOUDOULAS H, 1974, AM J CARDIOL, V34, P501, DOI 10.1016/0002-9149(74)90118-0
   Buchthal SD, 2000, NEW ENGL J MED, V342, P829, DOI 10.1056/NEJM200003233421201
   Buffon A, 2000, AM J PHYSIOL-HEART C, V279, pH2627, DOI 10.1152/ajpheart.2000.279.6.H2627
   Cox ID, 1999, J AM COLL CARDIOL, V34, P455, DOI 10.1016/S0735-1097(99)00224-7
   Desideri G, 2000, CIRCULATION, V102, P2359, DOI 10.1161/01.CIR.102.19.2359
   Egashira K, 1999, DEV CARDIOVASC MED, V213, P91
   EGASHIRA K, 1993, NEW ENGL J MED, V328, P1659, DOI 10.1056/NEJM199306103282302
   Fichtlscherer S, 2000, CIRCULATION, V102, P1000, DOI 10.1161/01.CIR.102.9.1000
   KASKI JC, 1995, J AM COLL CARDIOL, V25, P807, DOI 10.1016/0735-1097(94)00507-M
   KASKI JC, 1995, BRIT HEART J, V74, P620
   LIUZZO G, 1994, NEW ENGL J MED, V331, P417, DOI 10.1056/NEJM199408183310701
   MOLLICHELLI N, 2002, HEART, V87, P54
   Panting JR, 2002, NEW ENGL J MED, V346, P1948, DOI 10.1056/NEJMoa012369
   Pasceri V, 2000, CIRCULATION, V102, P2165
   QUYYUMI AA, 1992, CIRCULATION, V86, P1864, DOI 10.1161/01.CIR.86.6.1864
   Rosano GMC, 1996, EUR HEART J, V17, P1175
   Tousoulis D, 2001, CLIN CARDIOL, V24, P301, DOI 10.1002/clc.4960240409
   Tracy RP, 1997, ARTERIOSCL THROM VAS, V17, P1121, DOI 10.1161/01.ATV.17.6.1121
   VANE JR, 1990, NEW ENGL J MED, V323, P27
   Yudkin JS, 1999, ARTERIOSCL THROM VAS, V19, P972, DOI 10.1161/01.ATV.19.4.972
   ZEIHER AM, 1995, CIRCULATION, V91, P2345, DOI 10.1161/01.CIR.91.9.2345
NR 23
TC 125
Z9 130
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD MAY 7
PY 2003
VL 41
IS 9
BP 1468
EP 1474
DI 10.1016/S0735-1097(03)00243-2
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 674HR
UT WOS:000182631800007
PM 12742283
OA Bronze
DA 2025-06-11
ER

PT J
AU Furuto, Y
   Kawamura, M
   Yamashita, J
   Yoshikawa, T
   Namikawa, A
   Isshiki, R
   Takahashi, H
   Shibuya, Y
AF Furuto, Yoshitaka
   Kawamura, Mariko
   Yamashita, Jumpei
   Yoshikawa, Takahiro
   Namikawa, Akio
   Isshiki, Rei
   Takahashi, Hiroko
   Shibuya, Yuko
TI Relationship Between Helicobacter pylori Infection and
   Arteriosclerosis
SO INTERNATIONAL JOURNAL OF GENERAL MEDICINE
LA English
DT Review
DE Helicobacter pylori infection; arteriosclerosis; hypertension
ID ISCHEMIC-HEART-DISEASE; BLOOD-PRESSURE; ATHEROSCLEROTIC DISEASES;
   CORONARY ATHEROSCLEROSIS; ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; VIRULENT-STRAINS; OXIDATIVE STRESS; ASSOCIATION
AB It is reported that Helicobacter pylori (H. pylori) infection may be linked to non-digestive tract diseases, such as arteriosclerosis including dyslipidemia, diabetes, obesity, hypertension, and cardiovascular disease. Therefore, we reviewed recent studies available in PubMed dealing with the mechanisms of arteriosclerosis due to H. pylori infection and the effects of H. pylori eradication. Conventional studies suggested that H. pylori infection may increase the risk of arteriosclerosis. A large interventional study is required to clarify the causal relationships and the effects of bacterial eradication.
C1 [Furuto, Yoshitaka; Kawamura, Mariko; Yamashita, Jumpei; Yoshikawa, Takahiro; Namikawa, Akio; Isshiki, Rei; Takahashi, Hiroko; Shibuya, Yuko] NTT Med Ctr, Dept Hypertens & Nephrol, Shinagawa Ku, 5-9-22 Higasi Gotanda, Tokyo 1418625, Japan.
C3 Kanto Medical Center NTT EC
RP Furuto, Y (corresponding author), NTT Med Ctr, Dept Hypertens & Nephrol, Shinagawa Ku, 5-9-22 Higasi Gotanda, Tokyo 1418625, Japan.
EM furuto19761006@yahoo.co.jp
CR Akbas HS, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-92
   Albaker WI, 2011, SAUDI J GASTROENTERO, V17, P165, DOI 10.4103/1319-3767.80377
   Ambrosini G, 2011, EUR J OBSTET GYN R B, V155, P157, DOI 10.1016/j.ejogrb.2010.12.001
   ASAKA M, 1992, GASTROENTEROLOGY, V102, P760, DOI 10.1016/0016-5085(92)90156-S
   Aslan M, 2008, ATHEROSCLEROSIS, V196, P270, DOI 10.1016/j.atherosclerosis.2006.10.024
   Ayada K, 2009, CLIN REV ALLERG IMMU, V37, P44, DOI 10.1007/s12016-008-8097-7
   Bagnis A, 2012, DIGEST LIVER DIS, V44, P963, DOI 10.1016/j.dld.2012.05.009
   Beydoun MA, 2018, ALZHEIMERS DEMENT, V14, P1148, DOI 10.1016/j.jalz.2018.04.009
   Blum A, 2011, AM J MED, V124, P1171, DOI 10.1016/j.amjmed.2011.08.015
   Çakmak SK, 2009, INT J DERMATOL, V48, P1174, DOI 10.1111/j.1365-4632.2009.04145.x
   Cammarota G, 2000, DIGEST LIVER DIS, V32, P65, DOI 10.1016/S1590-8658(00)80047-X
   Campuzano-Maya G, 2011, WORLD J GASTROENTERO, V17, P3165, DOI 10.3748/wjg.v17.i26.3165
   Cho IS, 2005, AM J EPIDEMIOL, V162, P579, DOI 10.1093/aje/kwi237
   Consolazio A, 2004, ALIMENT PHARM THERAP, V20, P289, DOI 10.1111/j.1365-2036.2004.02074.x
   Coskun S, 2008, PEDIATR INT, V50, P150, DOI 10.1111/j.1442-200X.2008.02542.x
   Dahl LK, 2005, INT J EPIDEMIOL, V34, P967, DOI 10.1093/ije/dyh317
   Danesh J, 1998, BRIT MED J, V316, P1130, DOI 10.1136/bmj.316.7138.1130
   Eeskandarian R, 2012, CARDIOVASC J AFR, V23, P131, DOI 10.5830/CVJA-2011-016
   Elizalde JI, 2004, HELICOBACTER, V9, P681, DOI 10.1111/j.1083-4389.2004.00271.x
   Elizalde JI, 2002, ALIMENT PHARM THER, V16, P577, DOI 10.1046/j.1365-2036.2002.01202.x
   Fagoonee S, 2010, MINERVA MED, V101, P121
   Figura N, 2014, J CLIN PATHOL, V67, DOI 10.1136/jclinpath-2013-201743
   FORMAN D, 1993, LANCET, V341, P1359
   Fox JG, 1999, CANCER RES, V59, P4823
   Gen R, 2010, SOUTH MED J, V103, P190, DOI 10.1097/SMJ.0b013e3181cf373f
   Grebowska Aneta, 2006, Polish Journal of Microbiology, V55, P25
   Heuschmann PU, 2001, STROKE, V32, P2253, DOI 10.1161/hs1001.097096
   Huang BS, 2011, DIGEST DIS SCI, V56, P109, DOI 10.1007/s10620-010-1274-6
   Iwai N, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0221349
   Jafarzadeh A, 2009, DIGEST DIS SCI, V54, P2612, DOI 10.1007/s10620-008-0686-z
   Jalalzadeh Mojgan, 2012, J Nephropathol, V1, P170, DOI 10.5812/nephropathol.8115
   Jukic A, 2017, THER CLIN RISK MANAG, V13, P933, DOI 10.2147/TCRM.S142193
   Kanbay M, 2005, DIGEST DIS SCI, V50, P1228, DOI 10.1007/s10620-005-2764-9
   Kato S, 2006, INT J CANCER, V119, P1558, DOI 10.1002/ijc.21810
   Kebapcilar L, 2009, INTERNAL MED, V48, P2055, DOI 10.2169/internalmedicine.48.2562
   Kong XL, 2017, INT UROL NEPHROL, V49, P845, DOI 10.1007/s11255-016-1498-2
   Kopacova M, 2014, WORLD J GASTROENTERO, V20, P5625, DOI 10.3748/wjg.v20.i19.5625
   Kowalski M, 2001, J Physiol Pharmacol, V52, P3
   Lee YY, 2012, HELICOBACTER, V17, P54, DOI 10.1111/j.1523-5378.2011.00917.x
   Lin SY, 2015, INT J CLIN PRACT, V69, P604, DOI 10.1111/ijcp.12602
   Longo-Mbenza B, 2007, INT J CARDIOL, V121, P229, DOI 10.1016/j.ijcard.2006.12.003
   Longo-Mbenza B, 2007, West Afr J Med, V26, P183
   Longo-Mbenza B, 2012, VASC HEALTH RISK MAN, V8, P455, DOI 10.2147/VHRM.S28680
   Lu Ye-Hsu, 2002, Kaohsiung J Med Sci, V18, P266
   Maciorkowska E, 2005, WORLD J GASTROENTERO, V11, P6745, DOI 10.3748/wjg.v11.i43.6745
   Mayr M, 2006, J AM COLL CARDIOL, V47, P2436, DOI 10.1016/j.jacc.2006.03.024
   Mestrovic Tomislav, 2012, Lijec Vjesn, V134, P292
   Migneco A, 2003, HELICOBACTER, V8, P585, DOI 10.1111/j.1523-5378.2003.00180.x
   Moyaert H, 2008, HELICOBACTER, V13, P47, DOI 10.1111/j.1523-5378.2008.00634.x
   Murray LJ, 2000, ATHEROSCLEROSIS, V149, P379, DOI 10.1016/S0021-9150(99)00325-1
   Nakamura S, 2012, GUT, V61, P507, DOI 10.1136/gutjnl-2011-300495
   Nasrat SAM, 2015, CARDIOL RES, V6, P221, DOI 10.14740/cr382e
   Nazligul Y, 2011, CLIN BIOCHEM, V44, P647, DOI 10.1016/j.clinbiochem.2011.03.001
   Ng QX, 2018, HELICOBACTER, V23, DOI 10.1111/hel.12455
   Niccoli G, 2010, CORONARY ARTERY DIS, V21, P217, DOI 10.1097/MCA.0b013e3283399f36
   Oluyemi Aderemi, 2012, BMC Res Notes, V5, P284, DOI 10.1186/1756-0500-5-284
   Pellicano R, 2009, INT ANGIOL, V28, P469
   Pellicano R, 2008, LANCET INFECT DIS, V8, P254, DOI 10.1016/S1473-3099(08)70066-5
   Pellicano R, 2009, HELICOBACTER, V14, P58, DOI 10.1111/j.1523-5378.2009.00699.x
   Pierantozzi M, 2006, NEUROLOGY, V66, P1824, DOI 10.1212/01.wnl.0000221672.01272.ba
   Rechcinski Tomasz, 2002, Acta Microbiol Pol, V51, P339
   Rogha M, 2012, ARYA ATHEROSCLER, V8, P5
   Rogha M, 2012, ARYA ATHEROSCLER, V7, P138
   Russo F, 2001, IMMUNOPHARM IMMUNOT, V23, P13, DOI 10.1081/IPH-100102563
   Satoh H, 2010, J ATHEROSCLER THROMB, V17, P1041, DOI 10.5551/jat.5157
   Scharnagl H, 2004, AM J CARDIOL, V93, P219, DOI 10.1016/j.amjcard.2003.09.045
   Slomiany BL, 2013, INFLAMMOPHARMACOLOGY, V21, P241, DOI 10.1007/s10787-013-0169-5
   Slomiany BL, 2013, INFLAMMOPHARMACOLOGY, V21, P67, DOI 10.1007/s10787-012-0141-9
   Sotuneh N, 2014, INT J PREVENTIVE MED, V5, P1537
   Strachan DP, 1998, BRIT MED BULL, V54, P87
   Suzuki M, 2009, CELL HOST MICROBE, V5, P23, DOI 10.1016/j.chom.2008.11.010
   Tamer GS, 2009, DIGEST DIS SCI, V54, P1253, DOI 10.1007/s10620-008-0482-9
   Tamura A, 2002, AM J GASTROENTEROL, V97, P861, DOI 10.1111/j.1572-0241.2002.05601.x
   Thjodleifsson B, 2008, SCAND J INFECT DIS, V40, P381, DOI 10.1080/00365540701708293
   Torres AM, 2002, REV ESP CARDIOL, V55, P652
   Vijayvergiya R, 2015, WORLD J CARDIOL, V7, P134, DOI 10.4330/wjc.v7.i3.134
   Wan ZC, 2018, J HUM HYPERTENS, V32, P158, DOI 10.1038/s41371-017-0028-8
   Wang DZ, 2015, CLIN INTERV AGING, V10, P813, DOI 10.2147/CIA.S72724
   Wang JQ, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0197563
   Watanabe J, 2021, ANTIBIOTICS-BASEL, V10, DOI 10.3390/antibiotics10020156
   Wincup PH, 1997, HEART, V77, P294, DOI 10.1136/hrt.77.3.294
   Xu CF, 2014, HELICOBACTER, V19, P437, DOI 10.1111/hel.12153
   Yang GH, 2014, J GASTROEN HEPATOL, V29, P1794, DOI 10.1111/jgh.12617
   Yusuf SW, 2002, ACTA CARDIOL, V57, P317, DOI 10.2143/AC.57.5.2005446
   Zhang S, 2008, CHINESE MED J-PEKING, V121, P946, DOI 10.1097/00029330-200805020-00015
   Zhou XY, 2013, DIABETES RES CLIN PR, V99, P200, DOI 10.1016/j.diabres.2012.11.012
   Zhu JH, 2004, CIRCULATION, V109, P36, DOI 10.1161/01.CIR.0000105513.37677.B3
NR 87
TC 12
Z9 12
U1 1
U2 30
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-7074
J9 INT J GEN MED
JI Int. J. Gen. Med.
PY 2021
VL 14
BP 1533
EP 1540
DI 10.2147/IJGM.S303071
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA RS7GE
UT WOS:000643942400001
PM 33935515
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lee, M
   Kowdley, KV
AF Lee, Maximilian
   Kowdley, Kris V.
TI Alcohol's Effect on Other Chronic Liver Diseases
SO CLINICS IN LIVER DISEASE
LA English
DT Article
DE Alcohol; Autoimmune hepatitis; Fatty liver disease; Hepatitis B;
   Hepatitis C; Hemochromatosis; Fibrosis; Cirrhosis
ID HEPATITIS-C VIRUS; HIGH-FAT DIET; HEPATOCELLULAR-CARCINOMA; HEREDITARY
   HEMOCHROMATOSIS; FIBROSIS PROGRESSION; METABOLIC SYNDROME; CORE PROTEIN;
   B-VIRUS; CIGARETTE-SMOKING; OXIDATIVE STRESS
AB In addition to directly causing liver disease, alcohol consumption is a common comorbid condition with other chronic liver diseases and may exacerbate liver injury, particularly in nonalcoholic fatty liver disease, chronic viral hepatitis, hereditary hemochromatosis, and autoimmune liver diseases. This synergism can result in increased hepatic inflammation and accelerated rates of fibrosis, with more rapid and earlier development of cirrhosis, and also increase the risk for liver cancer and death from liver disease.
C1 [Lee, Maximilian; Kowdley, Kris V.] Virginia Mason Med Ctr, Liver Ctr Excellence, Seattle, WA 98101 USA.
C3 Virginia Mason Medical Center
RP Kowdley, KV (corresponding author), Virginia Mason Med Ctr, Liver Ctr Excellence, 1100 9th Ave,Mailstop C3-GAS, Seattle, WA 98101 USA.
EM kris.kowdley@vmmc.org
RI Kowdley, Kris/AAF-5202-2019
CR Adams PC, 1996, HEPATOLOGY, V23, P724, DOI 10.1053/jhep.1996.v23.pm0008666324
   Alkerwi A, 2009, ATHEROSCLEROSIS, V204, P624, DOI 10.1016/j.atherosclerosis.2008.10.036
   Armstrong GL, 2006, ANN INTERN MED, V144, P705, DOI 10.7326/0003-4819-144-10-200605160-00004
   Arteel Gavin E, 2012, Hepatology, V55, P2030, DOI 10.1002/hep.25721
   Baker SS, 2010, PLOS ONE, V5, pA82, DOI 10.1371/journal.pone.0009570
   Caldwell SH, 2009, ANN HEPATOL, V8, P346, DOI 10.1016/S1665-2681(19)31748-X
   Chitturi S, 2001, SEMIN LIVER DIS, V21, P27, DOI 10.1055/s-2001-12927
   Colell A, 1998, GASTROENTEROLOGY, V115, P1541, DOI 10.1016/S0016-5085(98)70034-4
   Cotrim HP, 2009, EUR J GASTROEN HEPAT, V21, P969, DOI 10.1097/MEG.0b013e328328f3ec
   Davis GL, 2010, GASTROENTEROLOGY, V138, P513, DOI 10.1053/j.gastro.2009.09.067
   DIEHL AM, 1988, GASTROENTEROLOGY, V95, P1056, DOI 10.1016/0016-5085(88)90183-7
   Donato F, 2002, AM J EPIDEMIOL, V155, P323, DOI 10.1093/aje/155.4.323
   Ekstedt M, 2009, SCAND J GASTROENTERO, V44, P366, DOI 10.1080/00365520802555991
   Encke J, 2000, ALCOHOL CLIN EXP RES, V24, P1063, DOI 10.1097/00000374-200007000-00018
   Fletcher LM, 2002, GASTROENTEROLOGY, V122, P281, DOI 10.1053/gast.2002.30992
   Gäbele E, 2011, ALCOHOL CLIN EXP RES, V35, P1361, DOI 10.1111/j.1530-0277.2011.01472.x
   Gelatti U, 2003, AM J GASTROENTEROL, V98, P907, DOI 10.1016/S0002-9270(02)06011-2
   Grundy SM, 2000, ENDOCRINE, V13, P155, DOI 10.1385/ENDO:13:2:155
   Gunji T, 2009, AM J GASTROENTEROL, V104, P2189, DOI 10.1038/ajg.2009.361
   Hamaguchi M, 2005, ANN INTERN MED, V143, P722, DOI 10.7326/0003-4819-143-10-200511150-00009
   Hamaguchi M, 2012, WORLD J GASTROENTERO, V18, P156, DOI 10.3748/wjg.v18.i2.156
   Harrison-Findik DD, 2010, WORLD J HEPATOL, V2, P302, DOI 10.4254/wjh.v2.i8.302
   Hiramine Y, 2011, J GASTROENTEROL, V46, P519, DOI 10.1007/s00535-010-0336-z
   Hutchinson SJ, 2005, CLIN GASTROENTEROL H, V3, P1150, DOI 10.1016/S1542-3565(05)00407-6
   Ikeda K, 1998, CANCER-AM CANCER SOC, V82, P827, DOI 10.1002/(SICI)1097-0142(19980301)82:5<827::AID-CNCR5>3.0.CO;2-G
   Jee SH, 2004, JNCI-J NATL CANCER I, V96, P1851, DOI 10.1093/jnci/djh334
   Kim WH, 2001, FASEB J, V15, P2551, DOI 10.1096/fj.01-0217
   Kim WH, 2005, CELL MOL IMMUNOL, V2, P40
   Larkin J, 2001, HEPATOLOGY, V34, P792, DOI 10.1053/jhep.2001.27565
   Lavanchy D, 2004, J VIRAL HEPATITIS, V11, P97, DOI 10.1046/j.1365-2893.2003.00487.x
   LUDWIG J, 1980, MAYO CLIN PROC, V55, P434
   Machida K, 2009, P NATL ACAD SCI USA, V106, P1548, DOI 10.1073/pnas.0807390106
   Marcellin P, 2008, J HEPATOL, V48, P200, DOI 10.1016/j.jhep.2007.09.010
   Miura K, 2008, HEPATOLOGY, V48, P1420, DOI 10.1002/hep.22486
   Monto A, 2004, HEPATOLOGY, V39, P826, DOI 10.1002/hep.20127
   Moriya A, 2011, ALIMENT PHARM THER, V33, P378, DOI 10.1111/j.1365-2036.2010.04520.x
   Mueller S, 2009, WORLD J GASTROENTERO, V15, P3462, DOI 10.3748/wjg.15.3462
   Nieto N, 2002, HEPATOLOGY, V35, P62, DOI 10.1053/jhep.2002.30362
   NOMURA H, 1988, AM J EPIDEMIOL, V128, P277, DOI 10.1093/oxfordjournals.aje.a114968
   Nomura Hideyuki, 1996, Fukuoka Acta Medica, V87, P237
   Ostapowicz G, 1998, HEPATOLOGY, V27, P1730, DOI 10.1002/hep.510270637
   Otani K, 2005, GASTROENTEROLOGY, V128, P96, DOI 10.1053/j.gastro.2004.10.045
   Perlemuter G, 2003, J HEPATOL, V39, P1020, DOI 10.1016/S0168-8278(03)00414-8
   Pianko S, 2001, J VIRAL HEPATITIS, V8, P406, DOI 10.1046/j.1365-2893.2001.00316.x
   Piccoli C, 2009, BBA-BIOENERGETICS, V1787, P539, DOI 10.1016/j.bbabio.2008.11.008
   Poynard T, 2003, J HEPATOL, V38, P257, DOI 10.1016/S0168-8278(02)00413-0
   Rigamonti C, 2003, HEPATOLOGY, V38, P42, DOI 10.1053/jhep.2003.50275
   Scotet V, 2003, AM J EPIDEMIOL, V158, P129, DOI 10.1093/aje/kwg123
   Siddique A, 2012, ALIMENT PHARM THER, V35, P876, DOI 10.1111/j.1365-2036.2012.05051.x
   Sorrentino P, 2010, J GASTROENTEROL, V45, P1053, DOI 10.1007/s00535-010-0249-x
   Sozio MS, 2009, NAT CLIN PRACT GASTR, V6, P18, DOI 10.1038/ncpgasthep1314
   Suzuki Y, 2002, ALCOHOL CLIN EXP RES, V26, p26S, DOI 10.1097/01.ALC.0000026830.27338.23
   Szabo G, 2010, ALCOHOL CLIN EXP RES, V34, P1675, DOI 10.1111/j.1530-0277.2010.01255.x
   Takahashi K, 2001, J GASTROEN HEPATOL, V16, P416, DOI 10.1046/j.1440-1746.2001.02462.x
   Thein HH, 2008, HEPATOLOGY, V48, P418, DOI 10.1002/hep.22375
   Thiele GM, 2010, ALCOHOL CLIN EXP RES, V34, P2126, DOI 10.1111/j.1530-0277.2010.01309.x
   Thorén F, 2004, J LEUKOCYTE BIOL, V76, P1180, DOI 10.1189/jlb.0704387
   Thun MJ, 1997, NEW ENGL J MED, V337, P1705, DOI 10.1056/NEJM199712113372401
   Valerio LG, 1996, ALCOHOL CLIN EXP RES, V20, P1352, DOI 10.1111/j.1530-0277.1996.tb01134.x
   Wang LY, 2003, CANCER CAUSE CONTROL, V14, P241, DOI 10.1023/A:1023636619477
   Wang Y, 2010, ALCOHOL CLIN EXP RES, V34, P567, DOI 10.1111/j.1530-0277.2009.01122.x
   Westin J, 2002, J VIRAL HEPATITIS, V9, P235, DOI 10.1046/j.1365-2893.2002.00356.x
   Wiley TE, 1998, HEPATOLOGY, V28, P805, DOI 10.1002/hep.510280330
   Wood MJ, 2012, HEPATOLOGY
   Ye L, 2010, DRUG ALCOHOL DEPEN, V112, P107, DOI 10.1016/j.drugalcdep.2010.05.008
   Zhang T, 2003, HEPATOLOGY, V38, P57, DOI 10.1053/jhep.2003.50295
   Zhu Gui-Ting, 2011, Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi, V25, P328
NR 67
TC 17
Z9 19
U1 0
U2 9
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1089-3261
EI 1557-8224
J9 CLIN LIVER DIS
JI Clin. Liver Dis.
PD NOV
PY 2012
VL 16
IS 4
BP 827
EP +
DI 10.1016/j.cld.2012.08.010
PG 12
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 058FL
UT WOS:000312619400011
PM 23101984
DA 2025-06-11
ER

PT J
AU Perez-Rubio, KG
   Villar, MMD
   Cortez-Navarrete, M
AF Perez-Rubio, Karina G.
   Mendez-del Villar, Miriam
   Cortez-Navarrete, Marisol
TI The Role of Garlic in Metabolic Diseases: A Review
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Review
DE dyslipidemia; garlic; hypertension; metabolic syndrome; obesity; type 2
   diabetes mellitus
ID TYPE-2 DIABETES-MELLITUS; BLOOD-PRESSURE; NITRIC-OXIDE; POWDER TABLETS;
   ORGANOSULFUR COMPOUNDS; DIETARY-SUPPLEMENTS; CARDIOVASCULAR RISK;
   SERUM-CHOLESTEROL; HYDROGEN-SULFIDE; OXIDATIVE STRESS
AB Garlic (Allium sativum L.) is a popular spice that has been widely used for thousands of years in traditional medicine. Several organosulfur compounds in garlic have been linked to its beneficial effects on health. Evidence from preclinical studies and clinical trials supports garlic's antihypertensive, antidiabetic, antiobesity, and hypolipidemic effects. This study aims to summarize clinical trial evidence regarding the effects of garlic on metabolic diseases and its mechanisms of action.
C1 [Perez-Rubio, Karina G.; Cortez-Navarrete, Marisol] Univ Guadalajara, Hlth Sci Univ Ctr, Inst Expt & Clin Therapeut, Dept Physiol, Guadalajara, Jalisco, Mexico.
   [Mendez-del Villar, Miriam] Univ Guadalajara, Univ Ctr Tonala, Multidisciplinary Hlth Res Ctr, Biomed Sci Dept, Tonala, Jalisco, Mexico.
   [Cortez-Navarrete, Marisol] Univ Guadalajara, Hlth Sci Univ Ctr, Inst Expt & Clin Therapeut, Dept Physiol, Sierra Mojada 950,Colonia Independencia, Guadalajara 44340, Mexico.
C3 Universidad de Guadalajara; Universidad de Guadalajara; Universidad de
   Guadalajara
RP Cortez-Navarrete, M (corresponding author), Univ Guadalajara, Hlth Sci Univ Ctr, Inst Expt & Clin Therapeut, Dept Physiol, Sierra Mojada 950,Colonia Independencia, Guadalajara 44340, Mexico.
EM marisol.cortez@academicos.udg.mx
RI Villar, Miriam/ABF-1251-2021
OI MENDEZ-DEL VILLAR, MIRIAM/0000-0002-9249-7709
CR Adler AJ, 1997, AM J CLIN NUTR, V65, P445, DOI 10.1093/ajcn/65.2.445
   Al-Qattan KK, 2006, J NUTR, V136, p774S, DOI 10.1093/jn/136.3.774S
   Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
   [Anonymous], 2015, International Journal of Academic Scientific Research
   Ansary J, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9070619
   Asemani Y, 2019, PHYTOTHER RES, V33, P3019, DOI 10.1002/ptr.6490
   Aslani N, 2016, INT J PREVENTIVE MED, V7, DOI 10.4103/2008-7802.187248
   Atkin M, 2016, J DIABETES COMPLICAT, V30, P723, DOI 10.1016/j.jdiacomp.2016.01.003
   Banerjee SK, 2002, NUTR J, V1, DOI 10.1186/1475-2891-1-4
   Banerjee SK, 2003, PHYTOTHER RES, V17, P97, DOI 10.1002/ptr.1281
   Benavides GA, 2007, P NATL ACAD SCI USA, V104, P17977, DOI 10.1073/pnas.0705710104
   Bisen PS, 2016, CURR NUTR FOOD SCI, V12, P190, DOI 10.2174/1573401312666160608121954
   BORDIA A, 1981, AM J CLIN NUTR, V34, P2100, DOI 10.1093/ajcn/34.10.2100
   Castro C, 2010, MOL NUTR FOOD RES, V54, P781, DOI 10.1002/mnfr.200900108
   Choudhary Prema Ram, 2018, Journal of Dietary Supplements, V15, P499, DOI 10.1080/19390211.2017.1358233
   Coletta C, 2012, P NATL ACAD SCI USA, V109, P9161, DOI 10.1073/pnas.1202916109
   Conway B, 2004, Obes Rev, V5, P145, DOI 10.1111/j.1467-789X.2004.00144.x
   Gebhardt R, 1996, LIPIDS, V31, P1269, DOI 10.1007/BF02587912
   Gomez-Arbelaez Diego, 2013, Mediators Inflamm, V2013, P285795, DOI 10.1155/2013/285795
   Gruenwald J, 2020, EXP THER MED, V19, P1490, DOI 10.3892/etm.2019.8378
   Hunter PM, 2017, NAT REV ENDOCRINOL, V13, P278, DOI 10.1038/nrendo.2016.210
   JAIN AK, 1993, AM J MED, V94, P632, DOI 10.1016/0002-9343(93)90216-C
   Jiang TA, 2019, J AOAC INT, V102, P395, DOI 10.5740/jaoacint.18-0418
   Joo H, 2013, FOOD CHEM TOXICOL, V55, P100, DOI 10.1016/j.fct.2012.12.044
   Jung ES, 2014, NUTRITION, V30, P1034, DOI 10.1016/j.nut.2014.02.014
   Keophiphath M, 2009, J NUTR, V139, P2055, DOI 10.3945/jn.109.105452
   Kopin Laurie, 2017, Ann Intern Med, V167, pITC81, DOI 10.7326/AITC201712050
   Kim EJ, 2012, J NUTR BIOCHEM, V23, P1552, DOI 10.1016/j.jnutbio.2011.10.008
   Kim-Park S, 2000, CLIN EXP PHARMACOL P, V27, P780, DOI 10.1046/j.1440-1681.2000.03333.x
   Kumar R, 2013, DIABET METAB SYND OB, V6, P49, DOI 10.2147/DMSO.S38888
   Lau BHS, 2006, J NUTR, V136, p765S, DOI 10.1093/jn/136.3.765S
   Lee, 2007, FASEB J, V21, pLB59
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   Nakasone Y, 2013, EXP THER MED, V5, P399, DOI 10.3892/etm.2012.819
   National Library of Medicine, PUBM MESH
   Oboh G, 2019, J DIET SUPPL, V16, P105, DOI 10.1080/19390211.2018.1438553
   Pareek S, 2019, BIOACTIVE FOOD DIETA, P245
   Park BM, 2017, J FUNCT FOODS, V30, P247, DOI 10.1016/j.jff.2017.01.024
   Park BM, 2016, J FUNCT FOODS, V22, P156, DOI 10.1016/j.jff.2016.01.034
   Phil RAM, 2011, J MED PLANTS RES, V5, P2922
   Putnik P, 2019, FOOD CHEM, V276, P680, DOI 10.1016/j.foodchem.2018.10.068
   Quesada I, 2020, CURR HYPERTENS REP, V22, DOI 10.1007/s11906-019-1009-9
   Riad K, 2018, FRONT NUTR, V5, DOI 10.3389/fnut.2018.00122
   Ried K, 2013, EUR J CLIN NUTR, V67, P64, DOI 10.1038/ejcn.2012.178
   Ried K, 2016, INTEGR BLOOD PRESS C, V9, P9, DOI 10.2147/IBPC.S93335
   Ried K, 2016, J NUTR, V146, p389S, DOI 10.3945/jn.114.202192
   Ried K, 2010, MATURITAS, V67, P144, DOI 10.1016/j.maturitas.2010.06.001
   Rossier BC, 2017, PHYSIOLOGY, V32, P112, DOI 10.1152/physiol.00026.2016
   Rudkowska I, 2012, MATURITAS, V72, P113, DOI 10.1016/j.maturitas.2012.03.001
   Sahebkar A, 2016, NUTRITION, V32, P33, DOI 10.1016/j.nut.2015.06.009
   Sangouni AA, 2021, PHYTOTHER RES, V35, P4433, DOI 10.1002/ptr.7146
   Sangouni AA, 2020, COMPLEMENT THER MED, V51, DOI 10.1016/j.ctim.2020.102428
   SENDL A, 1992, ATHEROSCLEROSIS, V94, P79, DOI 10.1016/0021-9150(92)90190-R
   Seo DY, 2012, NUTR RES PRACT, V6, P226, DOI 10.4162/nrp.2012.6.3.226
   Shabani E, 2019, PRIM CARE DIABETES, V13, P28, DOI 10.1016/j.pcd.2018.07.007
   Shang A, 2019, FOODS, V8, DOI 10.3390/foods8070246
   Sharifi F, 2010, INT J ENDOCRINOL MET, V8, P68
   Shoshi M.S.J., 2017, Journal of Enam Medical College, V7, P151, DOI DOI 10.3329/JEMC.V7I3.34075
   Singh DK, 2006, J NUTR, V136, p759S, DOI 10.1093/jn/136.3.759S
   Sobenin IA, 2008, ACTA DIABETOL, V45, P1, DOI 10.1007/s00592-007-0011-x
   Sobenin IA, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-119
   Sobenin IA, 2009, HYPERTENS RES, V32, P433, DOI 10.1038/hr.2009.36
   Sobenin IA, 2008, J ATHEROSCLER THROMB, V15, P334, DOI 10.5551/jat.E550
   Soleimani Davood, 2016, Adv Biomed Res, V5, P2, DOI 10.4103/2277-9175.174962
   Spigelski D, 2001, NUTR REV, V59, P236
   Suetsuna K, 1998, J NUTR BIOCHEM, V9, P415, DOI 10.1016/S0955-2863(98)00036-9
   Sun YE, 2018, MEDICINE, V97, DOI [10.1097/md.0000000000010255, 10.1097/MD.0000000000010255]
   Takashima M, 2017, PHYTOMEDICINE, V24, P56, DOI 10.1016/j.phymed.2016.11.016
   Thomson M., 2007, International Journal of Diabetes and Metabolism, V15, P108
   Ushijima M, 2018, J PHARM PHARMACOL, V70, P559, DOI 10.1111/jphp.12865
   Xu CJ, 2018, CLIN NUTR ESPEN, V24, P148, DOI 10.1016/j.clnesp.2017.11.010
   Yang C, 2018, NUTR METAB, V15, DOI 10.1186/s12986-018-0275-x
   Yang JY, 2006, OBESITY, V14, P388, DOI 10.1038/oby.2006.52
   Zeng T, 2012, J SCI FOOD AGR, V92, P1892, DOI 10.1002/jsfa.5557
   Zhang M, 2017, CELL PHYSIOL BIOCHEM, V41, P2255, DOI 10.1159/000475640
NR 75
TC 8
Z9 8
U1 1
U2 20
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD JUL 1
PY 2022
VL 25
IS 7
BP 683
EP 694
DI 10.1089/jmf.2021.0146
EA JUN 2022
PG 12
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA 3A9FR
UT WOS:000807876800001
PM 35675656
DA 2025-06-11
ER

PT J
AU Sen, N
   Tavil, Y
   Erdamar, H
   Yazici, HU
   Çakir, E
   Bilgi, C
   Erbil, MK
   Poyraz, F
   Okyay, K
   Turfan, M
   Cemri, M
   Akgul, EO
AF Sen, Nihat
   Tavil, Yusuf
   Erdamar, Huesamettin
   Yazici, Hueseyin Ugur
   Cakir, Erdinc
   Bilgi, Cumhur
   Erbil, Mehmet Kemal
   Poyraz, Fatih
   Okyay, Kaan
   Turfan, Murat
   Cemri, Mustafa
   Akgul, Emin Ozgur
TI Nebivolol therapy improves endothelial function and increases exercise
   tolerance in patients with cardiac syndrome X
SO ANADOLU KARDIYOLOJI DERGISI-THE ANATOLIAN JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Cardiac syndrome X; nebivolol; endothelial function; asymmetric
   dimethylarginine; nitric oxide
ID NORMAL CORONARY-ARTERIES; TYPE-2 DIABETES-MELLITUS; OXIDE SYNTHASE
   INHIBITOR; ORAL L-ARGININE; ASYMMETRIC DIMETHYLARGININE;
   ESSENTIAL-HYPERTENSION; DOUBLE-BLIND; MICROVASCULAR FUNCTION; FOREARM
   VASCULATURE; ANGINA-PECTORIS
AB Objective: We sought to determine whether nebivolol affects coronary endothelial function and exercise induced ischemia in patients with cardiac syndrome X (CSX).
   Methods: The study protocol undertaken was based on a single-blind randomized controlled prospective study. After a 2-week washout period, 38 patients with cardiac syndrome X were randomized to receive either nebivolol 5 mg daily (n=19) or metoprolol 50 mg daily (n=19) in a single-blind design for 12 weeks. The control group under study was consisted of 16 age- and gender-matched subjects with negative treadmill exercise tests. Plasma endothelial nitric oxide INN), L-arginine, and asymmetric dimethylarginine (ADMA) were measured in all patients at baseline and after 12 weeks of treatment. Statistical differences among groups were tested by one-way analysis of variance and unpaired samples t test for parametric; Kruskal-Wallis and Mann-Whitney U tests for non-parametric variables, respectively. A paired - samples t test was used to compare continuous variables before and after drug therapy.
   Results: At baseline, plasma level of NOx, L-arginine, and L-arginine/ADMA ratio were lower (p<0.001 for all) in patients with CSX than in the control patients. Whereas, the plasma ADMA levels were increased in the patient group (p<0.001). After 12 weeks of drug therapy, the patients taking nebivolol had increased levels of plasma NOx, plasma L-arginine, the L-arginine/ADMA ratio and decreased levels of plasma ADMA compared to those of the patients taking metoprolol (p<0.001). In addition, exercise duration to 1-mm ST depression and total exercise duration significantly increased after treatment in the nebivolol group compared to the metoprolol group (p<0.01). In the nebivolol group, Canadian Cardiovascular Society INS) angina classification improved by one or more categories in 12 (70%) patients, whereas it deteriorated or remained in the same category in 5 (30%) patients. Meanwhile, in the metoprolol group, the CCS angina classification improved by one or more categories in 7 (41%), whereas it deteriorated or remained in the same category in 10 (59%) patients.
   Conclusion: Circulating endothelial function parameters (plasma ADMA, L-arginine, NOx levels) were impaired in patients with CSX. Nebivolol treatment was associated with better improvements in both circulating endothelial function and exercise stress test parameters than metoprolol. We believe that further studies are needed to evaluate the effects of nebivolol treatment on long-term clinical outcomes in patients with CSX. (Anadolu Kardiyol Derg 2009;9:371-9)
C1 [Sen, Nihat; Tavil, Yusuf; Yazici, Hueseyin Ugur; Poyraz, Fatih; Okyay, Kaan; Turfan, Murat; Cemri, Mustafa] Gazi Univ, Fac Med, Dept Cardiol, Ankara, Turkey.
   [Erdamar, Huesamettin] Beytepe Mil Hosp, Dept Biochem, Ankara, Turkey.
   [Cakir, Erdinc; Bilgi, Cumhur] Gulhane Mil Med Acad, Dept Emergency Med, Ankara, Turkey.
   [Erbil, Mehmet Kemal; Akgul, Emin Ozgur] Gulhane Mil Med Acad, Dept Biochem, Ankara, Turkey.
C3 Gazi University; Beytepe Military Hospital; Gulhane Military Medical
   Academy; Gulhane Military Medical Academy
RP Sen, N (corresponding author), Gazi Univ, Fac Med, Dept Cardiol, Ankara, Turkey.
EM nihatdrsen@yahoo.com
RI Durakoglugil, Emre/Q-3547-2019; Turfan, Murat/B-8972-2014; Poyraz,
   Fatih/JZD-3254-2024; okyay, kaan/AAK-7355-2020
OI okyay, kaan/0000-0001-6134-8826
CR Abbasi F, 2001, AM J CARDIOL, V88, P1201, DOI 10.1016/S0002-9149(01)02063-X
   Bassand JP, 2007, EUR HEART J, V28, P1598, DOI 10.1093/eurheartj/ehm161
   BOWMAN AJ, 1994, BRIT J CLIN PHARMACO, V38, P199, DOI 10.1111/j.1365-2125.1994.tb04342.x
   Campeau L, 2002, CAN J CARDIOL, V18, P371
   Chen BM, 1997, J CHROMATOGR B, V692, P467, DOI 10.1016/S0378-4347(96)00531-2
   Chen JW, 2002, AM J CARDIOL, V90, P974, DOI 10.1016/S0002-9149(02)02664-4
   COCKCROFT JR, 1995, J PHARMACOL EXP THER, V274, P1067
   Cooke JP, 2000, ARTERIOSCL THROM VAS, V20, P2032, DOI 10.1161/01.ATV.20.9.2032
   Cosentino F, 2002, J HYPERTENS, V20, P421, DOI 10.1097/00004872-200203000-00017
   Dawes M, 1999, BRIT J CLIN PHARMACO, V48, P460
   EGASHIRA K, 1993, NEW ENGL J MED, V328, P1659, DOI 10.1056/NEJM199306103282302
   Fragasso G, 1997, HEART, V77, P32, DOI 10.1136/hrt.77.1.32
   GAO YS, 1991, J CARDIOVASC PHARM, V17, P964, DOI 10.1097/00005344-199106000-00016
   Ignarro LJ, 2002, NITRIC OXIDE-BIOL CH, V7, P75, DOI 10.1016/S1089-8603(02)00112-X
   Jadhav S, 2006, J AM COLL CARDIOL, V48, P956, DOI 10.1016/j.jacc.2006.04.088
   Kayikcioglu M, 2003, EUR HEART J, V24, P1999, DOI 10.1016/S0195-668X(03)00478-0
   KEMP HG, 1973, AM J CARDIOL, V32, P375, DOI 10.1016/S0002-9149(73)80150-X
   Kolasinska-Kloch W, 2002, SCAND J CLIN LAB INV, V62, P7, DOI 10.1080/003655102753517145
   Leiper J, 1999, CARDIOVASC RES, V43, P542, DOI 10.1016/S0008-6363(99)00162-5
   Lu TM, 2004, AM J CARDIOL, V94, P157, DOI 10.1016/j.amjcard.2004.03.052
   Miranda KM, 2001, NITRIC OXIDE-BIOL CH, V5, P62, DOI 10.1006/niox.2000.0319
   Miyazaki H, 1999, CIRCULATION, V99, P1141, DOI 10.1161/01.CIR.99.9.1141
   Oguz A, 2007, ANATOL J CARDIOL, V7, P383
   Palloshi A, 2004, AM J CARDIOL, V93, P933, DOI 10.1016/j.amjcard.2003.12.040
   Ritter JM, 2001, J CARDIOVASC PHARM, V38, pS13, DOI 10.1097/00005344-200112003-00003
   Stühlinger MC, 2002, JAMA-J AM MED ASSOC, V287, P1420, DOI 10.1001/jama.287.11.1420
   Surdacki A, 1999, J CARDIOVASC PHARM, V33, P652, DOI 10.1097/00005344-199904000-00020
   Taddei S, 2002, DRUGS, V62, P265, DOI 10.2165/00003495-200262020-00003
   Tzemos N, 2001, CIRCULATION, V104, P511, DOI 10.1161/hc3001.094207
   Van Nueten L, 1998, J HUM HYPERTENS, V12, P135, DOI 10.1038/sj.jhh.1000571
   VANDEWATER A, 1988, J CARDIOVASC PHARM, V11, P552, DOI 10.1097/00005344-198805000-00007
   VANDEWATER A, 1988, EUR J PHARMACOL, V156, P95, DOI 10.1016/0014-2999(88)90151-3
   Walker HA, 2001, J AM COLL CARDIOL, V38, P499, DOI 10.1016/S0735-1097(01)01380-8
   YAVAS N, 2006, ASSESSMENT AFFECTS N
NR 34
TC 32
Z9 32
U1 0
U2 10
PU AVES YAYINCILIK
PI FINDIKZADE
PA IBRAHIM KARA, KIZILELMA CAD 5-3, FINDIKZADE, ISTANBUL 34096, TURKEY
SN 1302-8723
J9 ANADOLU KARDIYOL DER
JI Anadolu Kardiyol. Derg.
PD OCT
PY 2009
VL 9
IS 5
BP 371
EP 379
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 512QU
UT WOS:000271265900003
PM 19819787
DA 2025-06-11
ER

PT J
AU Li, KL
   Li, T
   Yang, T
   Lin, YZ
   Liao, YT
   Gan, ZY
AF Li, Kanglai
   Li, Tong
   Yang, Ting
   Lin, Youzhen
   Liao, Yingtao
   Gan, Zhaoyu
TI Prevalence of insulin resistance and its associated factors in
   drug-naïve patients with bipolar disorder among Han Chinese population
SO BMC PSYCHIATRY
LA English
DT Article
DE Bipolar disorder; Insulin resistance; Metabolic syndrome; Waist
   circumference; Clinical characteristics
ID METABOLIC SYNDROME; DIABETES-MELLITUS; MOOD DISORDERS; RATING-SCALE;
   FEATURES; DEPRESSION; SYMPTOMS; DISEASE; ILLNESS; OBESITY
AB Background Metabolic syndrome (Mets) is commonly seen in bipolar disorder (BD). As the key component and early biological index of Mets, insulin resistance (IR) among BD has received more and more attention. However, little is known about the prevalence of IR and its associated factors in drug-na & iuml;ve patients with (BD), especially among Han Chinese population. Methods A cross-sectional study was conducted on 125 drug-na & iuml;ve patients with bipolar disorder (BD) and 85 healthy controls (HC). The Homeostatic Model Assessment of insulin resistance (HOMA-IR) was calculated, and IR was defined as HOMA-IR greater than the 75th percentile value for health controls (2.35). Clinical characteristics of BD were collected through semi-structural interview performed by a trained interviewer with background of psychiatric education. Results Among the measured anthropocentric variables including BMI, waist circumference, abdomen circumference, hipline, and hip-waist ratio, waist circumference was found to be the most closely related to IR (0R = 1.070, 95%CI = 1.031-1.110, P < 0.001). Male was another factor that was associated with IR (OR = 2.281, 95%CI = 1.107-4.702, P = 0.025). After adjusted for gender and waist circumference, the risk of IR was significantly higher in bipolar disorder than in healthy controls (OR = 2.66, 95%CI = 1.364-5.214, P = 0.004). No significant association was found between IR and any of the observed physical and mental comorbidities, any characteristic of illness course including age onset, number of mixed episodes, types of current state, duration of current episode, duration of illness course, rapid cycling, number of mood episodes, and subgroup of BD. Hypersomnia was the only symptomatic feature that was significantly associated with IR (OR = 0.316, 95%CI = 0.124-0.803, P = 0.016). Conclusions Bipolar disorder increases two-to-three-fold risk of IR, both circumference and male are the risk factors of IR but hypersomnia act as a protective factor.
C1 [Li, Kanglai; Li, Tong; Yang, Ting; Lin, Youzhen; Liao, Yingtao; Gan, Zhaoyu] Sun Yat Sen Univ, Affiliated Hosp 3, 600 Tianhe Rd, Guangzhou, Guangdong, Peoples R China.
C3 Sun Yat Sen University
RP Gan, ZY (corresponding author), Sun Yat Sen Univ, Affiliated Hosp 3, 600 Tianhe Rd, Guangzhou, Guangdong, Peoples R China.
EM ganzhy@mail.sysu.edu.cn
FU Third Affiliated Hospital of Sun Yat-Sen University, Clinical Research
   Program and the Natural Science Foundation of Guangdong Province, China
FX Not applicable.
CR Albert U, 2013, GEN HOSP PSYCHIAT, V35, P154, DOI 10.1016/j.genhosppsych.2012.10.004
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Arnold SE, 2018, NAT REV NEUROL, V14, P168, DOI 10.1038/nrneurol.2017.185
   Banos G., 2011, Cardiovascular & Hematological Agents in Medicinal Chemistry, V9, P137
   Bortolasci CC, 2015, J AFFECT DISORDERS, V179, P148, DOI 10.1016/j.jad.2015.03.041
   Cairns K, 2018, J PSYCHIATR RES, V102, P34, DOI 10.1016/j.jpsychires.2018.03.006
   Calkin CV, 2019, ANN MED, V51, P281, DOI 10.1080/07853890.2019.1659511
   Calkin CV, 2015, BRIT J PSYCHIAT, V206, P52, DOI 10.1192/bjp.bp.114.152850
   Carli M, 2021, PHARMACEUTICALS-BASE, V14, DOI 10.3390/ph14030238
   Chae WR, 2023, EUR NEUROPSYCHOPHARM, V71, P25, DOI 10.1016/j.euroneuro.2023.03.007
   Coello K, 2019, INT J BIPOLAR DISORD, V7, DOI 10.1186/s40345-019-0142-3
   Crump C, 2013, JAMA PSYCHIAT, V70, P931, DOI 10.1001/jamapsychiatry.2013.1394
   Ferrannini E, 2006, ANN MED, V38, P42, DOI 10.1080/07853890500415358
   Geer EB, 2009, GENDER MED, V6, P60, DOI 10.1016/j.genm.2009.02.002
   Guha P, 2014, INDIAN J CLIN BIOCHE, V29, P51, DOI 10.1007/s12291-012-0292-x
   Hadley C, 2008, J EPIDEMIOL COMMUN H, V62, P980, DOI 10.1136/jech.2007.068460
   HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
   Ilyas A, 2019, MOL CELL ENDOCRINOL, V497, DOI 10.1016/j.mce.2018.10.005
   Katsuki A, 2001, DIABETES CARE, V24, P362, DOI 10.2337/diacare.24.2.362
   Kim SJ, 2005, J NEURAL TRANSM, V112, P179, DOI 10.1007/s00702-004-0163-6
   Lasserre AM, 2014, JAMA PSYCHIAT, V71, P880, DOI 10.1001/jamapsychiatry.2014.411
   Madden AM, 2016, J HUM NUTR DIET, V29, P7, DOI 10.1111/jhn.12278
   Mansur RB, 2016, J AFFECT DISORDERS, V195, P57, DOI 10.1016/j.jad.2016.02.002
   Matulewicz N, 2016, POSTEP HIG MED DOSW, V70, P1245
   McIntyre Roger S, 2005, Ann Clin Psychiatry, V17, P83, DOI 10.1080/10401230590932380
   Miola A, 2023, J AFFECT DISORDERS, V334, P1, DOI 10.1016/j.jad.2023.04.068
   Mohammed W, 2022, CUREUS J MED SCIENCE, V14, DOI 10.7759/cureus.22021
   Morris G, 2017, NEUROSCI BIOBEHAV R, V74, P1, DOI 10.1016/j.neubiorev.2017.01.014
   Nieves DJ, 2003, DIABETES, V52, P172, DOI 10.2337/diabetes.52.1.172
   Onat A, 2006, METABOLISM, V55, P445, DOI 10.1016/j.metabol.2005.10.005
   Petrelli A, 2021, CURR DIABETES REP, V21, DOI 10.1007/s11892-021-01430-3
   Ramirez-Manent JI, 2023, Nutrients, V15
   Ross R, 2020, NAT REV ENDOCRINOL, V16, P177, DOI 10.1038/s41574-019-0310-7
   Ruzickova M, 2003, CAN J PSYCHIAT, V48, P458, DOI 10.1177/070674370304800705
   Salvi V, 2020, J AFFECT DISORDERS, V266, P610, DOI 10.1016/j.jad.2020.01.145
   Schuster MP, 2021, J AFFECT DISORDERS, V295, P1161, DOI 10.1016/j.jad.2021.08.139
   Shell AL, 2022, J BEHAV MED, V45, P882, DOI 10.1007/s10865-022-00356-9
   So E., 2003, Hong Kong J Psychiatry, V13, P7
   Steardo L, 2019, J AFFECT DISORDERS, V245, P174, DOI 10.1016/j.jad.2018.10.360
   Taylor V, 2010, CAN J PSYCHIAT, V55, P362, DOI 10.1177/070674371005500605
   van der Heide LP, 2005, J NEUROCHEM, V94, P1158, DOI 10.1111/j.1471-4159.2005.03269.x
   Vancampfort D, 2015, J CLIN PSYCHIAT, V76, P1490, DOI 10.4088/JCP.14r09635
   Wallace TM, 2004, DIABETES CARE, V27, P1487, DOI 10.2337/diacare.27.6.1487
   Wulsin LR, 2018, BIPOLAR DISORD, V20, P658, DOI 10.1111/bdi.12633
   YOUNG RC, 1978, BRIT J PSYCHIAT, V133, P429, DOI 10.1192/bjp.133.5.429
NR 45
TC 0
Z9 0
U1 1
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD MAY 23
PY 2024
VL 24
IS 1
AR 388
DI 10.1186/s12888-024-05838-5
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA RU9S1
UT WOS:001230297500004
PM 38783222
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wang, Y
   Fu, W
   Liu, J
AF Wang, Yan
   Fu, Wei
   Liu, Jing
TI Neurodevelopment in children with intrauterine growth restriction:
   adverse effects and interventions
SO JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
LA English
DT Review
DE Adverse effects; interventions; intrauterine growth restriction;
   neurodevelopment
ID INDIVIDUALIZED DEVELOPMENTAL CARE; INDUCED CEREBRAL APOPTOSIS;
   FOR-GESTATIONAL-AGE; PRETERM INFANTS; FETAL RATS; COGNITIVE FUNCTION;
   ASSESSMENT PROGRAM; OXIDATIVE STRESS; YOUNG-ADULTS; RISK-FACTORS
AB Intrauterine growth restriction (IUGR) is associated with higher rates of fetal, perinatal, and neonatal morbidity and mortality. The consequences of IUGR include short-term metabolic, hematological and thermal disturbances that lead to metabolic syndrome in children and adults. Additionally, IUGR severely affects short- and long-term fetal brain development and brain function (including motor, cognitive and executive function) and neurobehavior, especially neuropsychology. This review details the adverse effects of IUGR on fetal brain development and discusses intervention strategies.
C1 [Wang, Yan; Fu, Wei; Liu, Jing] Beijing Mil Gen Hosp, Dept Neonatol & NICU, Bayi Childrens Hosp, Beijing 100700, Peoples R China.
   [Wang, Yan] Taian City Cent Hosp Shandong Prov, Dept Neonatol & NICU, Tai An, Shandong, Peoples R China.
RP Liu, J (corresponding author), Beijing Mil Gen Hosp, Dept Neonatol & NICU, Bayi Childrens Hosp, 5 Nanmen Cang, Beijing 100700, Peoples R China.
EM liujingbj@live.cn
RI Liu, Jing/AFQ-7746-2022
FU National Natural Science Foundation of China [81170577, 81471087]
FX The authors declare that they have no competing interests. This work was
   supported by the National Natural Science Foundation of China (81170577
   & 81471087).
CR Akhtar N, 2012, ADV CHILD DEV BEHAV, V42, P41
   Als H, 2012, J PERINATOL, V32, P797, DOI 10.1038/jp.2011.201
   Als H, 2011, J PERINATOL, V31, P130, DOI 10.1038/jp.2010.81
   Anttila H, 2008, BMC PEDIATR, V8, DOI 10.1186/1471-2431-8-14
   Barker ED, 2013, OBSTET GYNECOL, V122, P248, DOI 10.1097/AOG.0b013e31829ca9a7
   Black RE, 2003, LANCET, V361, P2226, DOI 10.1016/S0140-6736(03)13779-8
   Burke C, 2006, BRAIN RES, V1098, P19, DOI 10.1016/j.brainres.2006.04.129
   Businelli C, 2015, J MATERN-FETAL NEO M, V28, P1302, DOI 10.3109/14767058.2014.953474
   Chen H, 2011, ZHONGHUA WEICHANG YI, V14, P612
   Chernausek SD, 2012, J CLIN ENDOCR METAB, V97, P689, DOI 10.1210/jc.2011-2741
   Chesney RW, 1998, ADV EXP MED BIOL, V442, P463
   Dobbs MA, 2012, REV SCI INSTRUM, V83, DOI 10.1063/1.4737629
   Dubois J, 2008, BRAIN, V131, P2028, DOI 10.1093/brain/awn137
   Duncan JR, 2004, DEV BRAIN RES, V153, P243, DOI 10.1016/j.devbrainres.2004.09.004
   Duy AP, 2013, ARCH PEDIATRIE, V20, P1034, DOI 10.1016/j.arcped.2013.06.008
   Escobar RS, 2014, APPETITE, V81, P337, DOI 10.1016/j.appet.2014.06.107
   Fattal-Valevski A, 2009, J CHILD NEUROL, V24, P846, DOI 10.1177/0883073808331082
   Galano A, 2011, J PINEAL RES, V51, P1, DOI 10.1111/j.1600-079X.2011.00916.x
   Geva R, 2008, J CHILD PSYCHOL PSYC, V49, P1321, DOI 10.1111/j.1469-7610.2008.01917.x
   Gharibani PM, 2013, ADV EXP MED BIOL, V776, P241, DOI 10.1007/978-1-4614-6093-0_23
   Guellec I, 2011, PEDIATRICS, V127, pE883, DOI 10.1542/peds.2010-2442
   Head LM, 2015, J PEDIATR HEALTH CAR, V29, P126, DOI 10.1016/j.pedhc.2014.08.015
   Heinonen K, 2010, BMC PEDIATR, V10, DOI 10.1186/1471-2431-10-91
   Hernández-Benítez R, 2012, STEM CELL RES, V9, P24, DOI 10.1016/j.scr.2012.02.004
   Jacobsson B, 2008, BJOG-INT J OBSTET GY, V115, P1250, DOI 10.1111/j.1471-0528.2008.01827.x
   Jarvis S, 2003, LANCET, V362, P1106, DOI 10.1016/S0140-6736(03)14466-2
   Klaric AS, 2012, EUR J PAEDIATR NEURO, V16, P132, DOI 10.1016/j.ejpn.2011.06.003
   Kliegman R., 2011, FANAROFF MARTINS NEO, P245
   Kok RD, 2002, MAGNET RESON MED, V48, P611, DOI 10.1002/mrm.10264
   Lane RH, 2001, BRAIN RES, V895, P186, DOI 10.1016/S0006-8993(01)02074-1
   Lane RH, 2001, AM J PHYSIOL-REG I, V280, pR183, DOI 10.1152/ajpregu.2001.280.1.R183
   Lauritz B, 2012, J DEV ORIG HLTH DIS, V3, P59, DOI 10.1017/S2040174411000729
   Lerdweeraphon W, 2013, AM J PHYSIOL-REG I, V305, pR95, DOI 10.1152/ajpregu.00142.2013
   Liu J, 2011, NEUROSCIENCE, V181, P265, DOI 10.1016/j.neuroscience.2011.02.056
   Liu J, 2015, METAB BRAIN DIS, V30, P67, DOI 10.1007/s11011-014-9572-x
   Liu J, 2014, MEDICINE, V93, DOI 10.1097/MD.0000000000000210
   Liu J, 2013, NUTR NEUROSCI, V16, P282, DOI 10.1179/1476830513Y.0000000057
   Liu J, 2013, NEURAL REGEN RES, V8, P2190, DOI 10.3969/j.issn.1673-5374.2013.23.009
   Liu J, 2012, NEUROPEDIATRICS, V43, P258, DOI 10.1055/s-0032-1324730
   Liu Y, 2014, ZHONGHUA WEI CHAN YI, V17, P312
   Lohaugen GCC, 2013, J PEDIATR-US, V163, P447, DOI 10.1016/j.jpeds.2013.01.060
   Longo S, 2013, J MATERN-FETAL NEO M, V26, P222, DOI 10.3109/14767058.2012.715006
   Mandruzzato G, 2008, J PERINAT MED, V36, P277, DOI 10.1515/JPM.2008.050
   McAnulty G, 2013, BMC PEDIATR, V13, DOI 10.1186/1471-2431-13-25
   McDonald M, 2012, NATURE, V488, P349, DOI 10.1038/nature11379
   Menzie J, 2014, AMINO ACIDS, V46, P31, DOI 10.1007/s00726-012-1382-z
   Mert I, 2012, J OBSTET GYNAECOL RE, V38, P658, DOI 10.1111/j.1447-0756.2011.01771.x
   Miller SL, 2014, J PINEAL RES, V56, P283, DOI 10.1111/jpi.12121
   Miyamoto N, 2009, NEUROSCIENCE, V162, P525, DOI 10.1016/j.neuroscience.2009.05.004
   Morioka N, 2010, J PHARMACOL SCI, V113, P234, DOI 10.1254/jphs.10031FP
   Morsing E, 2011, PEDIATRICS, V127, pE874, DOI 10.1542/peds.2010-1821
   Räikkönen K, 2008, ARCH GEN PSYCHIAT, V65, P290, DOI 10.1001/archgenpsychiatry.2007.40
   Rajesh M, 2013, J OBSTET GYN INDIA, V63, P37, DOI 10.1007/s13224-012-0210-4
   REITER RJ, 1993, EXPERIENTIA, V49, P654, DOI 10.1007/BF01923947
   Ripps H, 2012, MOL VIS, V18, P2673
   Rodriguez C, 2004, J PINEAL RES, V36, P1, DOI 10.1046/j.1600-079X.2003.00092.x
   Romo Agustin, 2009, Pediatr Endocrinol Rev, V6 Suppl 3, P332
   Ropacka-Lesiak M, 2014, GINEKOL POL, V85, P509
   Rosenberg A, 2008, SEMIN PERINATOL, V32, P219, DOI 10.1053/j.semperi.2007.11.003
   Salam RA, 2014, CURR OPIN CLIN NUTR, V17, P249, DOI 10.1097/MCO.0000000000000051
   Samuelsen GB, 2007, AM J OBSTET GYNECOL, V197, DOI 10.1016/j.ajog.2007.02.011
   Sankaran S, 2009, BEST PRACT RES CL OB, V23, P765, DOI 10.1016/j.bpobgyn.2009.05.003
   Sanz-Cortés M, 2010, ULTRASOUND OBST GYN, V36, P159, DOI 10.1002/uog.7724
   Schaffer SW, 2014, AMINO ACIDS, V46, P1, DOI 10.1007/s00726-013-1632-8
   Schmandke A, 2007, NEUROSCIENTIST, V13, P454, DOI 10.1177/1073858407303611
   Sehested LT, 2014, DAN MED J, V61
   Shah P., 2011, Obstetrics, Gynaecology and Reproductive Medicine, V21, P142, DOI DOI 10.1016/J.OGRM.2011.02.004
   Shivaraj MC, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0042935
   Smith GCS, 2007, LANCET, V370, P1715, DOI 10.1016/S0140-6736(07)61723-1
   Stoknes M, 2012, PEDIATRICS, V130, pE1629, DOI 10.1542/peds.2012-0152
   Story L, 2011, AM J OBSTET GYNECOL, V205, DOI 10.1016/j.ajog.2011.06.032
   Stromme KK, 2014, ACTA PAEDIATR, V103, P886, DOI 10.1111/apa.12657
   Tideman E, 2007, ULTRASOUND OBST GYN, V29, P614, DOI 10.1002/uog.4042
   Tolsa CB, 2004, PEDIATR RES, V56, P132, DOI 10.1203/01.PDR.0000128983.54614.7E
   Torrance HL, 2010, ULTRASOUND OBST GYN, V36, P171, DOI 10.1002/uog.7627
   Torres N, 2010, AM J PHYSIOL-ENDOC M, V298, pE270, DOI 10.1152/ajpendo.00437.2009
   Tronnes H, 2014, DEV MED CHILD NEUROL, V56, P779, DOI 10.1111/dmcn.12430
   Unterscheider J, 2013, AM J OBSTET GYNECOL, V208, DOI 10.1016/j.ajog.2013.02.007
   van Vliet E, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0064545
   Vasiliadis HM, 2008, ACTA PSYCHIAT SCAND, V117, P306, DOI 10.1111/j.1600-0447.2008.01168.x
   Walker N, 2010, INT J EPIDEMIOL, V39, P21, DOI 10.1093/ije/dyq036
   Yerushalmy-Feler A, 2014, J PEDIATR-US, V164, P756, DOI 10.1016/j.jpeds.2013.12.030
NR 82
TC 38
Z9 47
U1 1
U2 29
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1476-7058
EI 1476-4954
J9 J MATERN-FETAL NEO M
JI J. Matern.-Fetal Neonatal Med.
PD FEB 16
PY 2016
VL 29
IS 4
BP 660
EP 668
DI 10.3109/14767058.2015.1015417
PG 9
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA CY9RI
UT WOS:000366743600028
PM 25758617
DA 2025-06-11
ER

PT J
AU Van Gaal, LF
   Mertens, IL
   De Block, CE
AF Van Gaal, Luc F.
   Mertens, Ilse L.
   De Block, Christophe E.
TI Mechanisms linking obesity with cardiovascular disease
SO NATURE
LA English
DT Article
ID CORONARY-HEART-DISEASE; FREE FATTY-ACIDS; C-REACTIVE PROTEIN;
   INSULIN-RESISTANCE; ADIPOSE-TISSUE; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; RISK-FACTORS; MYOCARDIAL-INFARCTION; OXIDATIVE STRESS
AB Obesity increases the risk of cardiovascular disease and premature death. Adipose tissue releases a large number of bioactive mediators that influence not only body weight homeostasis but also insulin resistance - the core feature of type 2 diabetes - as well as alterations in lipids, blood pressure, coagulation, fibrinolysis and inflammation, leading to endothelial dysfunction and atherosclerosis. We are now beginning to understand the underlying mechanisms as well as the ways in which smoking and dyslipidaemia increase, and physical activity attenuates, the adverse effects of obesity on cardiovascular health.
C1 Univ Antwerp, Univ Antwerp Hosp, Fac Med, Dept Diabetol Metab & Clin Nutr, B-2650 Antwerp, Belgium.
C3 University of Antwerp
RP Van Gaal, LF (corresponding author), Univ Antwerp, Univ Antwerp Hosp, Fac Med, Dept Diabetol Metab & Clin Nutr, Wilrijkstr 10, B-2650 Antwerp, Belgium.
EM luc.van.gaal@uza.be
RI De+Block, Christophe/ABE-1600-2020
OI De Block, Christophe/0000-0002-0679-3203
CR Abel ED, 2001, NATURE, V409, P729, DOI 10.1038/35055575
   Adams KF, 2006, NEW ENGL J MED, V355, P763, DOI 10.1056/NEJMoa055643
   Alessi MC, 2006, ARTERIOSCL THROM VAS, V26, P2200, DOI 10.1161/01.ATV.0000242905.41404.68
   Alessi MC, 2003, ARTERIOSCL THROM VAS, V23, P1262, DOI 10.1161/01.ATV.0000077401.36885.BB
   Arita Y, 2002, CIRCULATION, V105, P2893, DOI 10.1161/01.CIR.0000018622.84402.FF
   Bastelica D, 2002, ARTERIOSCL THROM VAS, V22, P173, DOI 10.1161/hq0102.101552
   Berenson GS, 1998, NEW ENGL J MED, V338, P1650, DOI 10.1056/NEJM199806043382302
   Berg AH, 2005, CIRC RES, V96, P939, DOI 10.1161/01.RES.0000163635.62927.34
   Berg AH, 2004, AM J PHYSIOL-ENDOC M, V287, pE1178, DOI 10.1152/ajpendo.00002.2004
   BJORNTORP P, 1990, ARTERIOSCLEROSIS, V10, P493, DOI 10.1161/01.ATV.10.4.493
   Blair SN, 2004, JAMA-J AM MED ASSOC, V292, P1232, DOI 10.1001/jama.292.10.1232
   Blann AD, 1997, THROMB RES, V85, P433, DOI 10.1016/S0049-3848(97)00031-5
   Bornstein SR, 2000, DIABETES, V49, P532, DOI 10.2337/diabetes.49.4.532
   Cancello R, 2006, BJOG-INT J OBSTET GY, V113, P1141, DOI 10.1111/j.1471-0528.2006.01004.x
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Chan DC, 2002, METABOLISM, V51, P1041, DOI 10.1053/meta.2002.33339
   Després JP, 2001, BMJ-BRIT MED J, V322, P716, DOI 10.1136/bmj.322.7288.716
   Devaraj S, 2003, CIRCULATION, V107, P398, DOI 10.1161/01.CIR.0000052617.91920.FD
   Eckel RH, 2006, CIRCULATION, V113, P2943, DOI 10.1161/CIRCULATIONAHA.106.176583
   Esmon CT, 2005, BRIT J HAEMATOL, V131, P417, DOI 10.1111/j.1365-2141.2005.05753.x
   Esposito K, 2002, CIRCULATION, V106, P2067, DOI 10.1161/01.CIR.0000034509.14906.AE
   FACCHINI FS, 1992, LANCET, V339, P1128, DOI 10.1016/0140-6736(92)90730-Q
   Ferrannini E, 2006, ATHEROSCLEROSIS SUPP, V7, P5, DOI 10.1016/j.atherosclerosissup.2006.05.006
   Frénais R, 2001, J CLIN ENDOCR METAB, V86, P1962, DOI 10.1210/jc.86.5.1962
   Fukuhara A, 2005, SCIENCE, V307, P426, DOI 10.1126/science.1097243
   Gaudet D, 1998, CIRCULATION, V97, P871, DOI 10.1161/01.CIR.97.9.871
   Graham TE, 2006, NEW ENGL J MED, V354, P2552, DOI 10.1056/NEJMoa054862
   Haider DG, 2006, DIABETOLOGIA, V49, P1909, DOI 10.1007/s00125-006-0303-7
   Hanley AJG, 2004, DIABETES, V53, P1773, DOI 10.2337/diabetes.53.7.1773
   Holvoet P, 2004, DIABETES, V53, P1068, DOI 10.2337/diabetes.53.4.1068
   Howard BV, 2000, ARTERIOSCL THROM VAS, V20, P830, DOI 10.1161/01.ATV.20.3.830
   Howard BV, 2003, ENDOCRIN METAB CLIN, V32, P855, DOI 10.1016/S0889-8529(03)00073-2
   Hu FB, 2004, NEW ENGL J MED, V351, P2694, DOI 10.1056/NEJMoa042135
   Iwashima Y, 2005, HYPERTENSION, V45, P1094, DOI 10.1161/01.HYP.0000169444.05588.4c
   James PT, 2004, EUR J CARDIOV PREV R, V11, P3, DOI 10.1097/01.hjr.0000114707.27531.48
   Kenchaiah S, 2002, NEW ENGL J MED, V347, P305, DOI 10.1056/NEJMoa020245
   Kobayashi H, 2004, CIRC RES, V94, pE27, DOI 10.1161/01.RES.0000119921.86460.37
   Konstantinides S, 2001, J CLIN INVEST, V108, P1533, DOI 10.1172/JCI13143
   Kuk JL, 2006, OBESITY, V14, P336, DOI 10.1038/oby.2006.43
   Kumada M, 2004, CIRCULATION, V109, P2046, DOI 10.1161/01.CIR.0000127953.98131.ED
   Kwiterovich PO, 2002, AM J CARDIOL, V90, p30I
   Lakka TA, 2001, ATHEROSCLEROSIS, V154, P497, DOI 10.1016/S0021-9150(00)00514-1
   Lau DCW, 2005, AM J PHYSIOL-HEART C, V288, pH2031, DOI 10.1152/ajpheart.01058.2004
   Li TY, 2006, CIRCULATION, V113, P499, DOI 10.1161/CIRCULATIONAHA.105.574087
   Libby P, 2002, CIRCULATION, V105, P1135, DOI 10.1161/hc0902.104353
   Liu RH, 2004, J PHARMACOL EXP THER, V310, P52, DOI 10.1124/jpet.103.065037
   Maddux BA, 2001, DIABETES, V50, P404, DOI 10.2337/diabetes.50.2.404
   MANSON JE, 1995, NEW ENGL J MED, V333, P677, DOI 10.1056/NEJM199509143331101
   Matsuzawa Y, 2006, FEBS LETT, V580, P2917, DOI 10.1016/j.febslet.2006.04.028
   McGavock JM, 2006, ANN INTERN MED, V144, P517, DOI 10.7326/0003-4819-144-7-200604040-00011
   Mertens I, 2006, J THROMB HAEMOST, V4, P1164, DOI 10.1111/j.1538-7836.2006.01919.x
   Mertens I, 2002, Obes Rev, V3, P85, DOI 10.1046/j.1467-789X.2002.00056.x
   Mertens I, 2006, EUR J ENDOCRINOL, V155, P477, DOI 10.1530/eje.1.02239
   Montani JP, 2004, INT J OBESITY, V28, pS58, DOI 10.1038/sj.ijo.0802858
   Nicholls SJ, 2006, AM J CARDIOL, V97, P1553, DOI 10.1016/j.amjcard.2005.12.042
   Nigro J, 2006, ENDOCR REV, V27, P242, DOI 10.1210/er.2005-0007
   Olshansky SJ, 2005, NEW ENGL J MED, V352, P1138, DOI 10.1056/NEJMsr043743
   Ouchi N, 2003, HYPERTENSION, V42, P231, DOI 10.1161/01.HYP.0000083488.67550.B8
   Peeters A, 2003, ANN INTERN MED, V138, P24, DOI 10.7326/0003-4819-138-1-200301070-00008
   Pilz S, 2006, J CLIN ENDOCR METAB, V91, P2542, DOI 10.1210/jc.2006-0195
   Poirier P, 2006, CIRCULATION, V113, P898, DOI 10.1161/CIRCULATIONAHA.106.171016
   Pontiroli AF, 2004, EUR J ENDOCRINOL, V150, P195, DOI 10.1530/eje.0.1500195
   Rexrode KM, 1998, JAMA-J AM MED ASSOC, V280, P1843, DOI 10.1001/jama.280.21.1843
   Rutter MK, 2003, CIRCULATION, V107, P448, DOI 10.1161/01.CIR.0000045671.62860.98
   SANDVIK L, 1993, NEW ENGL J MED, V328, P533, DOI 10.1056/NEJM199302253280803
   Sattar N, 2004, DIABETES, V53, P2855, DOI 10.2337/diabetes.53.11.2855
   Singhal A, 2002, CIRCULATION, V106, P1919, DOI 10.1161/01.CIR.0000033219.24717.52
   Smith SR, 2006, J CLIN ENDOCR METAB, V91, P2506, DOI 10.1210/jc.2006-1018
   Stevens J, 2002, AM J EPIDEMIOL, V156, P832, DOI 10.1093/aje/kwf114
   Summers SA, 2006, PROG LIPID RES, V45, P42, DOI 10.1016/j.plipres.2005.11.002
   Szczepaniak LS, 2003, MAGN RESON MED, V49, P417, DOI 10.1002/mrm.10372
   TASKINEN M-R, 1987, Diabetes Metabolism Reviews, V3, P551
   Tripathy D, 2003, DIABETES, V52, P2882, DOI 10.2337/diabetes.52.12.2882
   van der Vaart H, 2004, THORAX, V59, P713, DOI 10.1136/thx.2003.012468
   Verlohren S, 2004, HYPERTENSION, V44, P271, DOI 10.1161/01.HYP.0000140058.28994.ec
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Yki-Järvinen H, 2005, CURR MOL MED, V5, P287, DOI 10.2174/1566524053766031
   Young ME, 2002, CIRCULATION, V105, P1861, DOI 10.1161/01.CIR.0000012467.61045.87
   Yusuf S, 2005, LANCET, V366, P1640, DOI 10.1016/S0140-6736(05)67663-5
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
   Zhou YT, 2000, P NATL ACAD SCI USA, V97, P1784, DOI 10.1073/pnas.97.4.1784
NR 81
TC 2152
Z9 2394
U1 7
U2 237
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
EI 1476-4687
J9 NATURE
JI Nature
PD DEC 14
PY 2006
VL 444
IS 7121
BP 875
EP 880
DI 10.1038/nature05487
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 116LW
UT WOS:000242805400045
PM 17167476
DA 2025-06-11
ER

PT J
AU Hayasaka, T
   Fuda, H
   Hui, SP
   Chiba, H
AF Hayasaka, Takahiro
   Fuda, Hirotoshi
   Hui, Shu-Ping
   Chiba, Hitoshi
TI Imaging Mass Spectrometry Reveals a Decrease of Cardiolipin in the
   Kidney of NASH Model Mice
SO ANALYTICAL SCIENCES
LA English
DT Article
DE Imaging; matrix-assisted laser desorption/ionization; non-alcoholic
   steatohepatitis; kidney; cardiolipin
ID NONALCOHOLIC FATTY LIVER; METABOLIC SYNDROME; OXIDATIVE STRESS; DISEASE;
   PREVALENCE; NAFLD
AB Non-alcoholic steatohepatitis (NASH) can be complicated with chronic kidney disease (CKD). In this study, changes in the distribution of biomolecules in the kidney were studied in NASH model mice with the use of imaging mass spectrometry (IMS). The mass spectra and ion images of IMS showed that the signals of cardiolipin (CL) species were decreased in the kidney cortex of the NASH mice. The decrease of CL might therefore suggest the kidney involvement of NASH.
C1 [Hayasaka, Takahiro; Fuda, Hirotoshi; Hui, Shu-Ping; Chiba, Hitoshi] Hokkaido Univ, Fac Hlth Sci, Hlth Innovat & Technol Ctr, Lab Adv Lipid Anal,Kita Ku, Kita 12,Nishi 5, Sapporo, Hokkaido 0600812, Japan.
C3 Hokkaido University
RP Hui, SP (corresponding author), Hokkaido Univ, Fac Hlth Sci, Hlth Innovat & Technol Ctr, Lab Adv Lipid Anal,Kita Ku, Kita 12,Nishi 5, Sapporo, Hokkaido 0600812, Japan.
FU Ministry of Education, Culture, Sports, Science and Technology, Japan;
   Japan Society for the Promotion of Science
FX This research is supported by the Regional Innovation Strategy Support
   Program, Sapporo Health Innovation "Smart-H", of the Ministry of
   Education, Culture, Sports, Science and Technology, Japan, and partially
   by the Grant-in-Aid for Scientific Research from the Japan Society for
   the Promotion of Science.
CR Aballay LR, 2013, NUTR REV, V71, P168, DOI 10.1111/j.1753-4887.2012.00533.x
   BACON BR, 1994, GASTROENTEROLOGY, V107, P1103, DOI 10.1016/0016-5085(94)90235-6
   BUTTKE TM, 1994, IMMUNOL TODAY, V15, P7, DOI 10.1016/0167-5699(94)90018-3
   Ford ES, 2010, J DIABETES, V2, P180, DOI 10.1111/j.1753-0407.2010.00078.x
   Hamed EA, 2012, J CANCER RES CLIN, V138, P999, DOI 10.1007/s00432-012-1176-4
   Hsu FF, 2005, J AM SOC MASS SPECTR, V16, P491, DOI 10.1016/j.jasms.2004.12.015
   Jansen-Chaparro S, 2012, EUR J INTERN MED, V23, P558, DOI 10.1016/j.ejim.2012.02.016
   Lin Y, 2012, LAB INVEST, V92, P265, DOI 10.1038/labinvest.2011.159
   Matteoni CA, 1999, GASTROENTEROLOGY, V116, P1413, DOI 10.1016/S0016-5085(99)70506-8
   Michelotti GA, 2013, NAT REV GASTRO HEPAT, V10, P656, DOI 10.1038/nrgastro.2013.183
   Ott M, 2002, P NATL ACAD SCI USA, V99, P1259, DOI 10.1073/pnas.241655498
   Sinha K, 2013, ARCH TOXICOL, V87, P1157, DOI 10.1007/s00204-013-1034-4
   Teli MR, 1995, HEPATOLOGY, V22, P1714, DOI 10.1016/0270-9139(95)90196-5
   Thomas GN, 2005, DIABETES RES CLIN PR, V67, P251, DOI 10.1016/j.diabres.2004.07.022
   Wree A, 2013, NAT REV GASTRO HEPAT, V10, P627, DOI 10.1038/nrgastro.2013.149
   Yasui K, 2011, METABOLISM, V60, P735, DOI 10.1016/j.metabol.2010.07.022
   Zhou XW, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/786528
NR 17
TC 10
Z9 11
U1 0
U2 13
PU JAPAN SOC ANALYTICAL CHEMISTRY
PI TOKYO
PA 26-2 NISHIGOTANDA 1 CHOME SHINAGAWA-KU, TOKYO, 141, JAPAN
SN 0910-6340
EI 1348-2246
J9 ANAL SCI
JI Anal. Sci.
PD APR
PY 2016
VL 32
IS 4
BP 473
EP 476
DI 10.2116/analsci.32.473
PG 4
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA DK8HS
UT WOS:000375168400016
PM 27063723
OA gold
DA 2025-06-11
ER

PT J
AU Naowar, M
   Dickton, D
   Francis, J
AF Naowar, Maisha
   Dickton, Darby
   Francis, Jimi
TI Cardiometabolic Risk Factors Associated with Magnesium and Vitamin D
   Nutrients during Pregnancy-A Narrative Review
SO NUTRIENTS
LA English
DT Review
DE gestational diabetes; gestational hypertension; cardiometabolic changes;
   vitamin D; magnesium
ID C-REACTIVE PROTEIN; D DEFICIENCY; INSULIN SENSITIVITY; UNITED-STATES;
   ION CHANNELS; HYPERTENSION; SUPPLEMENTATION; METABOLISM; CALCITRIOL;
   DEPRESSION
AB This narrative review comprehensively explores the cardiometabolic implications of two vital nutrients, magnesium and vitamin D, during gestation. Magnesium, a key regulator of vascular tone, glucose metabolism, and insulin sensitivity, plays a crucial role in mitigating gestational hypertension and diabetes, a point this review underscores. Conversely, vitamin D, critical for immune response and calcium level maintenance, is linked to gestational diabetes and hypertensive disorders of pregnancy. The authors aim to enhance comprehension of the complex interaction between these nutrients and cardiometabolic function in pregnancy, knowledge that is pivotal for optimizing maternal-fetal outcomes. The mother's health during pregnancy significantly influences the long-term development of the fetus. Recognizing the impact of these nutrient deficiencies on the physiology of cardiometabolic cycles underscores the importance of adequate nutritional support during pregnancy. It also emphasizes the pressing need for future research and targeted interventions to alleviate the burden of pregnancy complications, highlighting the crucial role of healthcare professionals, researchers, and policy makers in obstetrics and gynecology in this endeavor.
C1 [Naowar, Maisha] Univ Texas San Antonio, Coll Hlth Community & Policy, Dept Publ Hlth, San Antonio, TX 78249 USA.
   [Dickton, Darby] Fdn Maternal Infant & Lactat Knowledge, San Antonio, TX 78249 USA.
   [Francis, Jimi] Univ Texas San Antonio, Coll Hlth Community & Policy, Dept Kinesiol, San Antonio, TX 78249 USA.
C3 University of Texas System; University of Texas at San Antonio (UTSA);
   University of Texas System; University of Texas at San Antonio (UTSA)
RP Francis, J (corresponding author), Univ Texas San Antonio, Coll Hlth Community & Policy, Dept Kinesiol, San Antonio, TX 78249 USA.
EM maisha.naowar@my.utsa.edu; ddickton@foundation4milk.org;
   jimi.francis@utsa.edu
FX This research received no external funding.
CR AGUS ZS, 1991, ANNU REV PHYSIOL, V53, P299, DOI 10.1146/annurev.physiol.53.1.299
   Ahmadi S, 2018, MAGNESIUM RES, V31, P131, DOI 10.1684/mrh.2019.0446
   Aikawa J.K., 1981, Magnesium : its biologic significance
   Alvarez JA, 2010, INT J ENDOCRINOL, V2010, DOI 10.1155/2010/351385
   Amrein K, 2020, EUR J CLIN NUTR, V74, P1498, DOI 10.1038/s41430-020-0558-y
   An P, 2022, J AM COLL CARDIOL, V80, P2269, DOI 10.1016/j.jacc.2022.09.048
   [Anonymous], 2002, Diabetes Care, DOI DOI 10.2337/DIACARE.25.2007.S94
   Aranow C, 2011, J INVEST MED, V59, P881, DOI 10.2310/JIM.0b013e31821b8755
   Ashique S, 2023, J HEALTH POPUL NUTR, V42, DOI 10.1186/s41043-023-00423-0
   Barbagallo M, 2015, WORLD J DIABETES, V6, P1152, DOI 10.4239/wjd.v6.i10.1152
   Baz-Hecht M, 2010, CURR OPIN ENDOCRINOL, V17, P113, DOI 10.1097/MED.0b013e3283372859
   Benedik E, 2022, INT J VITAM NUTR RES, V92, P118, DOI 10.1024/0300-9831/a000733
   Borissova AM, 2003, INT J CLIN PRACT, V57, P258
   Brannon PM, 2012, P NUTR SOC, V71, P205, DOI 10.1017/S0029665111003399
   Cakal S, 2021, BLOOD PRESS MONIT, V26, P113, DOI 10.1097/MBP.0000000000000497
   Cashman KD, 2020, CALCIFIED TISSUE INT, V106, P14, DOI 10.1007/s00223-019-00559-4
   Catalano PM, 2003, J NUTR, V133, p1674S, DOI 10.1093/jn/133.5.1674S
   Contreras-Bolivar V, 2021, NUTRIENTS, V13, DOI 10.3390/nu13103491
   Dalan R, 2014, IJC METAB ENDOCR, V4, P4, DOI 10.1016/j.ijcme.2014.06.003
   Melo SRD, 2022, BIOL TRACE ELEM RES, V200, P3545, DOI 10.1007/s12011-021-02966-x
   Di Cianni G, 2003, DIABETES-METAB RES, V19, P259, DOI 10.1002/dmrr.390
   Le TD, 2022, CLIN MED INSIGHTS-EN, V15, DOI 10.1177/11795514221098403
   DiNicolantonio JJ, 2018, OPEN HEART, V5, DOI 10.1136/openhrt-2017-000668
   Dominguez LJ, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010180
   Domitrz I, 2022, NUTRIENTS, V14, DOI 10.3390/nu14051089
   dos Santos LM, 2023, ENDOCRINE, V80, P183, DOI 10.1007/s12020-022-03265-8
   Duley L, 2010, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD000025.pub2
   Durlach J, 2004, J AM COLL NUTR, V23, p694S, DOI 10.1080/07315724.2004.10719411
   Eisner DA, 2017, CIRC RES, V121, P181, DOI 10.1161/CIRCRESAHA.117.310230
   Endo S, 2006, GYNECOL ENDOCRINOL, V22, P343, DOI 10.1080/09513590600724836
   Fanni D, 2021, BIOL TRACE ELEM RES, V199, P3647, DOI 10.1007/s12011-020-02513-0
   Fiorentini D, 2021, NUTRIENTS, V13, DOI 10.3390/nu13041136
   Ford ND, 2022, MMWR-MORBID MORTAL W, V71, P585, DOI [10.15585/mmwr.mm7117a1, 10.15585/mmwr.m0m7117a1]
   Forman JP, 2010, HYPERTENSION, V55, P1283, DOI 10.1161/HYPERTENSIONAHA.109.148619
   Fritzen R, 2023, NUTRIENTS, V15, DOI 10.3390/nu15102355
   Gallo S, 2020, J ACAD NUTR DIET, V120, P898, DOI 10.1016/j.jand.2019.07.002
   Garrison SR, 2020, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD009402.pub3, 10.1002/14651858.CD009402.pub2]
   Granger JP, 2001, HYPERTENSION, V38, P718, DOI 10.1161/01.HYP.38.3.718
   Gröber U, 2015, NUTRIENTS, V7, P8199, DOI 10.3390/nu7095388
   Hollis BW, 2011, CURR OPIN ENDOCRINOL, V18, P371, DOI 10.1097/MED.0b013e32834b0040
   Houston M, 2011, J CLIN HYPERTENS, V13, P843, DOI 10.1111/j.1751-7176.2011.00538.x
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Ismail A. A. A., 2016, Journal of Nutrition and Food Sciences, V6, P523
   Jeyakumar A, 2021, J HEALTH POPUL NUTR, V40, DOI 10.1186/s41043-021-00253-y
   Jiang ZW, 2023, CRIT REV FOOD SCI, V63, P3602, DOI 10.1080/10408398.2021.1990850
   Karamali M, 2018, APPL PHYSIOL NUTR ME, V43, P565, DOI 10.1139/apnm-2017-0521
   Khazai Natasha, 2008, Curr Rheumatol Rep, V10, P110, DOI 10.1007/s11926-008-0020-y
   Kim DH, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020575
   Kinshella MLW, 2022, REPROD HEALTH, V19, DOI 10.1186/s12978-022-01485-9
   Kostov K, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19061724
   Krajewska M, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.920340
   Lee CC, 2022, J FORMOS MED ASSOC, V121, P1231, DOI 10.1016/j.jfma.2021.11.006
   Lin RL, 2023, J CLIN HYPERTENS, V25, P480, DOI 10.1111/jch.14657
   Mansur JL, 2022, NUTRIENTS, V14, DOI 10.3390/nu14091900
   Magee LA, 2018, MAYO CLIN PROC, V93, P1664, DOI 10.1016/j.mayocp.2018.04.033
   Marcinkevage JA, 2011, PRIM CARE DIABETES, V5, P81, DOI 10.1016/j.pcd.2010.10.002
   McCollum E V, 2002, J Biol Chem, V277, pE8
   METZGER BE, 1991, DIABETES, V40, P197, DOI 10.2337/diab.40.2.S197
   Nawsherwan, 2020, IRAN J PUBLIC HEALTH, V49, P2032, DOI 10.18502/ijph.v49i11.4717
   Olmos-Ortiz A, 2015, NUTRIENTS, V7, P443, DOI 10.3390/nu7010443
   Orlova S, 2021, BMC PREGNANCY CHILDB, V21, DOI 10.1186/s12884-021-03558-2
   Pelczynska M, 2022, NUTRIENTS, V14, DOI 10.3390/nu14091714
   Pitocco D, 2006, DIABETIC MED, V23, P920, DOI 10.1111/j.1464-5491.2006.01921.x
   Poel YHM, 2012, EUR J INTERN MED, V23, P465, DOI 10.1016/j.ejim.2012.01.007
   Quigley M, 2022, JBMR PLUS, V6, DOI 10.1002/jbm4.10572
   Razzaque MS, 2018, NUTRIENTS, V10, DOI 10.3390/nu10121863
   Redman C.W., 2010, Hypertension in Pregnancy. de Swiets Medical Disorders in Obstetric Practice
   Ren Q, 2023, BIOL TRACE ELEM RES, V201, P5115, DOI 10.1007/s12011-023-03591-6
   Rosanoff A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010195
   Rosanoff A, 2016, ADV NUTR, V7, P25, DOI 10.3945/an.115.008631
   Rosanoff A, 2012, NUTR REV, V70, P153, DOI 10.1111/j.1753-4887.2011.00465.x
   Roth DE, 2018, ANN NY ACAD SCI, V1430, P44, DOI 10.1111/nyas.13968
   Rude RK, 2003, CALCIFIED TISSUE INT, V72, P32, DOI 10.1007/s00223-001-1091-1
   Ryan BA, 2021, J ENDOCRINOL INVEST, V44, P643, DOI 10.1007/s40618-020-01387-2
   Saraf R, 2016, MATERN CHILD NUTR, V12, P647, DOI 10.1111/mcn.12210
   Schlegel RN, 2015, PLACENTA, V36, P750, DOI 10.1016/j.placenta.2015.03.011
   Schoenaker DAJM, 2014, BMC MED, V12, DOI 10.1186/s12916-014-0157-7
   Schutten JC, 2022, J AM HEART ASSOC, V11, DOI 10.1161/JAHA.121.021783
   Shamim N, 2023, J PAK MED ASSOC, V73, P500, DOI 10.47391/JPMA.5512
   Sonagra Amit D, 2014, J Clin Diagn Res, V8, pCC01, DOI 10.7860/JCDR/2014/10068.5081
   Standley CA, 1997, OBSTET GYNECOL, V89, P24, DOI 10.1016/S0029-7844(96)00380-8
   Tamblyn JA, 2015, J ENDOCRINOL, V224, pR107, DOI 10.1530/JOE-14-0642
   Tangvoraphonkchai K, 2018, ADV CHRONIC KIDNEY D, V25, P251, DOI 10.1053/j.ackd.2018.02.010
   Touyz R. M., 2003, Molecular Aspects of Medicine, V24, P107, DOI 10.1016/S0098-2997(02)00094-8
   Tranquilli AL, 2013, PREGNANCY HYPERTENS, V3, P44, DOI [10.1016/j.preghy.2012.11.001, 10.1016/j.preghy.2013.04.006]
   Traub Ariana, 2024, US Cardiol, V18, pe03, DOI 10.15420/usc.2023.01
   Uwitonze AM, 2018, J AM OSTEOPATH ASSOC, V118, P181, DOI 10.7556/jaoa.2018.037
   Vaidya A, 2010, HYPERTENSION, V56, P774, DOI 10.1161/HYPERTENSIONAHA.109.140160
   Wang W, 2021, BMC PREGNANCY CHILDB, V21, DOI 10.1186/s12884-021-03809-2
   Wei SQ, 2012, BJOG-INT J OBSTET GY, V119, P832, DOI 10.1111/j.1471-0528.2012.03307.x
   Wei SQ, 2013, J MATERN-FETAL NEO M, V26, P889, DOI 10.3109/14767058.2013.765849
   WHITE RE, 1989, BIOCHEM PHARMACOL, V38, P859, DOI 10.1016/0006-2952(89)90272-4
   Wium-Andersen MK, 2013, JAMA PSYCHIAT, V70, P176, DOI 10.1001/2013.jamapsychiatry.102
   WYNN A, 1988, Nutrition and Health (Bicester), V6, P69
   Yamagami R, 2019, BIOCHEMISTRY-US, V58, P3971, DOI 10.1021/acs.biochem.9b00578
   Yaribeygi H, 2019, J CELL PHYSIOL, V234, P8152, DOI 10.1002/jcp.27603
   Ye WR, 2022, BMJ-BRIT MED J, V377, DOI 10.1136/bmj-2021-067946
   Zarean Elaheh, 2017, Adv Biomed Res, V6, P109, DOI 10.4103/2277-9175.213879
   Zhu A, 2022, NUTRIENTS, V14, DOI 10.3390/nu14193894
NR 99
TC 1
Z9 1
U1 1
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2024
VL 16
IS 16
AR 2630
DI 10.3390/nu16162630
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA E7H7G
UT WOS:001304684900001
PM 39203767
OA gold
DA 2025-06-11
ER

PT J
AU Takeshita, J
   Grewal, S
   Langan, SM
   Mehta, NN
   Ogdie, A
   Van Voorhers, AS
   Gelfand, JM
AF Takeshita, Junko
   Grewal, Sungat
   Langan, Sinead M.
   Mehta, Nehal N.
   Ogdie, Alexis
   Van Voorhers, Abby S.
   Gelfand, Joel M.
TI Psoriasis and comorbid diseases Implications for management
SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
LA English
DT Review
DE cardiovascular disease; chronic kidney disease; comorbidities; Crohn's
   disease; depression; infection; lymphoma; metabolic syndrome;
   nonalcoholic fatty liver disease; psoriasis; psoriatic arthritis;
   screening; vaccination
ID POPULATION-BASED-COHORT; FACTOR-ALPHA THERAPY; CARDIOVASCULAR
   RISK-FACTORS; NECROSIS-FACTOR INHIBITORS; SQUAMOUS-CELL CARCINOMA;
   HEPATITIS-B-VIRUS; NATIONAL-PSORIASIS; RHEUMATOID-ARTHRITIS; BIOLOGIC
   THERAPY; TREATMENT RECOMMENDATIONS
AB As summarized in the first article in this continuing medical education series, the currently available epidemiologic data suggest that psoriasis may be a risk factor for cardiometabolic disease. Emerging data also suggest associations between psoriasis and other comorbidities beyond psoriatic arthritis, including chronic kidney disease, inflammatory bowel disease, hepatic disease, certain malignancies, infections, and mood disorders. Recognizing the comorbid disease burden of psoriasis is essential for ensuring comprehensive care of patients with psoriasis. The clinical implications of the comorbid diseases that are associated with psoriasis and recommendations for clinical management are reviewed in this article.
C1 [Takeshita, Junko; Grewal, Sungat; Gelfand, Joel M.] Univ Penn, Perelman Sch Med, Dept Dermatol, Philadelphia, PA 19104 USA.
   [Takeshita, Junko; Ogdie, Alexis; Gelfand, Joel M.] Univ Penn, Ctr Clin Epidemiol & Biostat, Perelman Sch Med, Dept Epidemiol & Biostat, Philadelphia, PA 19104 USA.
   [Ogdie, Alexis] Univ Penn, Perelman Sch Med, Div Rheumatol, Philadelphia, PA 19104 USA.
   [Langan, Sinead M.] London Sch Hyg & Trop Med, London, England.
   [Langan, Sinead M.] St Johns Inst Dermatol, London, England.
   [Mehta, Nehal N.] NHLBI, Bldg 10, Bethesda, MD 20892 USA.
   [Van Voorhers, Abby S.] Eastern Virginia Med Sch, Dept Dermatol, Norfolk, VA 23501 USA.
C3 University of Pennsylvania; University of Pennsylvania; University of
   Pennsylvania; University of London; London School of Hygiene & Tropical
   Medicine; University of London; King's College London; National
   Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood
   Institute (NHLBI); Eastern Virginia Medical School
RP Takeshita, J (corresponding author), Univ Penn, Perelman Ctr Adv Med, Dept Dermatol, 3400 Civ Ctr Blvd,7th Floor,South Tower,Off 728, Philadelphia, PA 19104 USA.
EM Junko.Takeshita@uphs.upenn.edu
RI Mehta, Nehal/W-4669-2019
OI Gelfand, Joel/0000-0003-3480-2661; Langan, Sinead/0000-0002-7022-7441
FU National Institute of Arthritis and Musculoskeletal and Skin Diseases
   [K24AR064310, T32AR00746532, K23AR063764, K23AR068433]; Dermatology
   Foundation Career Development Award; Intramural Research Program at the
   National Institutes of Health [ZIAHL006193-02]; National Institute for
   Health Research Clinician Scientist Fellowship [NIHR/CS/010/014]; Pfizer
   Inc; AbbVie; Celgene; Amgen; Eli Lilly; Janssen; Novartis Corp;
   Regeneron
FX Supported in part by National Institute of Arthritis and Musculoskeletal
   and Skin Diseases grants K24AR064310 (Dr Gelfand), T32AR00746532 (Ms
   Grewal), K23AR063764 (Dr Ogdie), and K23AR068433 (Dr Takeshita), a
   Dermatology Foundation Career Development Award (Dr Takeshita), the
   Intramural Research Program at the National Institutes of Health grant
   ZIAHL006193-02 (Mehta), and a National Institute for Health Research
   Clinician Scientist Fellowship (grant NIHR/CS/010/014 to Dr Langan). The
   findings and conclusions in this report are those of the authors and do
   not necessarily represent the views of the UK Department of Health.Dr
   Takeshita has received a research grant (to the Trustees of the
   University of Pennsylvania) from Pfizer Inc and payment for continuing
   medical education work related to psoriasis. Dr Mehta is a full-time
   employee of the US Government. Dr Ogdie receives research grants from
   AbbVie (to the Group for Research and Assessment of Psoriasis and
   Psoriatic Arthritis [GRAPPA]), Celgene (to GRAPPA), and Pfizer Inc (to
   the Trustees of the University of Pennsylvania and GRAPPA), and has
   served as a consultant for Novartis, receiving honoraria. Dr Van
   Voorhees has served as a consultant for AbbVie, Amgen, Aqua,
   AstraZeneca, Celgene, Corrona, Dermira, Janssen, Leo, Novartis, and
   Pfizer, receiving honoraria; received a research grant from AbbVie; and
   has other relationship with Merck. Dr Gelfand has served as a consultant
   for AbbVie, AstraZeneca, Celgene Corp, Coherus, Eli Lilly, Janssen
   Biologics (formerly Centocor), Sanofi, Merck, Novartis Corp, Endo, and
   Pfizer Inc, receiving honoraria; receives research grants (to the
   Trustees of the University of Pennsylvania) from AbbVie, Amgen, Eli
   Lilly, Janssen, Novartis Corp, Regeneron, and Pfizer Inc; and received
   payment for continuing medical education work related to psoriasis. Dr
   Gelfand is a co-patent holder of resiquimod for treatment of cutaneous
   T-cell lymphoma. No other potential conflicts of interest were declared
   by the authors.
CR Abuabara K, 2011, BRIT J DERMATOL, V165, P1066, DOI 10.1111/j.1365-2133.2011.10525.x
   Ahlehoff O, 2013, J INTERN MED, V273, P197, DOI 10.1111/j.1365-2796.2012.02593.x
   Al-Mutairi N, 2014, EXPERT OPIN BIOL TH, V14, P749, DOI 10.1517/14712598.2014.900541
   Alamdari Habibollah S, 2013, J Drugs Dermatol, V12, pe14
   Amer Diabet Assoc, 2014, DIABETES CARE, V37, pS14, DOI 10.2337/dc14-S014
   [Anonymous], 1991, JAMA, V265, P3255
   [Anonymous], 2015, DIABETES CARE, V38, pS4, DOI 10.2337/dc15-S003
   [Anonymous], 2015, DIABETES CARE, V38, pS1, DOI 10.2337/dc15-S001
   [Anonymous], 2015, ABN BLOOD GLUC TYP 2
   Armstrong AW, 2015, J AM ACAD DERMATOL, V72, P968, DOI 10.1016/j.jaad.2015.02.1095
   Armstrong AW, 2013, JAMA DERMATOL, V149, P1180, DOI 10.1001/jamadermatol.2013.5264
   Armstrong AW, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0018227
   Askling J, 2011, PHARMACOEPIDEM DR S, V20, P119, DOI 10.1002/pds.2046
   Azfar RS, 2012, ARCH DERMATOL, V148, P995, DOI 10.1001/archdermatol.2012.1401
   Barnabe C, 2011, ARTHRIT CARE RES, V63, P522, DOI 10.1002/acr.20371
   Bath-Hextall F, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005414.pub2
   Bissonnette R, 2013, CIRC-CARDIOVASC IMAG, V6, P83, DOI 10.1161/CIRCIMAGING.112.975730
   Boetticher NC, 2008, GASTROENTEROLOGY, V135, P1953, DOI 10.1053/j.gastro.2008.08.057
   Branson Bernard M., 2006, Morbidity and Mortality Weekly Report, V55, P1
   Brauchli YB, 2009, J INVEST DERMATOL, V129, P2604, DOI 10.1038/jid.2009.113
   Calonge N, 2008, ANN INTERN MED, V149, P627, DOI 10.7326/0003-4819-149-9-200811040-00243
   Calonge N, 2007, ANN INTERN MED, V147, P783, DOI 10.7326/0003-4819-147-11-200712040-00009
   Calonge N, 2009, ANN INTERN MED, V151, P716, DOI 10.7326/0003-4819-151-10-200911170-00008
   Chen YJ, 2012, ARTHRITIS RHEUM-US, V64, P1879, DOI 10.1002/art.34335
   Chi CC, 2015, J DERMATOL SCI, V78, P232, DOI 10.1016/j.jdermsci.2015.03.012
   Clark L, 2008, J AM ACAD DERMATOL, V58, P443, DOI 10.1016/j.jaad.2007.11.011
   Coates LC, 2016, ARTHRITIS RHEUMATOL, V68, P1060, DOI 10.1002/art.39573
   Dixon WG, 2010, ANN RHEUM DIS, V69, P522, DOI 10.1136/ard.2009.118935
   Dommasch ED, 2015, BRIT J DERMATOL, V173, P975, DOI 10.1111/bjd.14032
   Dommasch ED, 2011, J AM ACAD DERMATOL, V64, P1035, DOI 10.1016/j.jaad.2010.09.734
   Eckel RH, 2014, CIRCULATION, V129, pS76, DOI 10.1161/01.cir.0000437740.48606.d1
   Fayad ZA, 2011, LANCET, V378, P1547, DOI 10.1016/S0140-6736(11)61383-4
   FREIS ED, 1990, HYPERTENSION, V16, P472, DOI 10.1161/01.HYP.16.4.472
   Friedewald VE, 2008, AM J CARDIOL, V102, P1631, DOI 10.1016/j.amjcard.2008.10.004
   Gelfand JM, 2006, J INVEST DERMATOL, V126, P2194, DOI 10.1038/sj.jid.5700410
   Gisondi P, 2008, AM J CLIN NUTR, V88, P1242, DOI 10.3945/ajcn.2008.26427
   Goff DC Jr, 2014, J AM COLL CARDIOL, V63, P2935, DOI 10.1016/j.jacc.2013.11.005
   Goulabchand R, 2014, ANN RHEUM DIS, V73, P414, DOI 10.1136/annrheumdis-2012-202641
   Grijalva CG, 2011, JAMA-J AM MED ASSOC, V306, P2331, DOI 10.1001/jama.2011.1692
   Hearn RMR, 2008, BRIT J DERMATOL, V159, P931, DOI 10.1111/j.1365-2133.2008.08776.x
   Herron MD, 2005, ARCH DERMATOL, V141, P1527, DOI 10.1001/archderm.141.12.1527
   Hong Y, 2014, J INVEST DERMATOL, V134, pS50
   Horn EJ, 2007, J AM ACAD DERMATOL, V57, P957, DOI 10.1016/j.jaad.2007.06.042
   Hueber W, 2012, GUT, V61, P1693, DOI 10.1136/gutjnl-2011-301668
   Kadakia KC, 2012, CANCER-AM CANCER SOC, V118, P2128, DOI 10.1002/cncr.26374
   Kalb RE, 2009, J AM ACAD DERMATOL, V60, P824, DOI 10.1016/j.jaad.2008.11.906
   Kao LT, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0116077
   Kim DK, 2015, MMWR-MORBID MORTAL W, V64, P91, DOI 10.7326/M14-2755
   Kimball AB, 2008, J AM ACAD DERMATOL, V58, P1031, DOI 10.1016/j.jaad.2008.01.006
   Kimball AB, 2012, J AM ACAD DERMATOL, V67, P76, DOI 10.1016/j.jaad.2011.06.035
   Kurd SK, 2010, ARCH DERMATOL, V146, P891, DOI 10.1001/archdermatol.2010.186
   Kwoh CK, 2002, ARTHRITIS RHEUM-US, V46, P328
   Langman G, 2001, J GASTROEN HEPATOL, V16, P1395, DOI 10.1046/j.1440-1746.2001.02644.x
   Lebwohl MG, 2014, J AM ACAD DERMATOL, V70, P871, DOI 10.1016/j.jaad.2013.12.018
   Mäki-Petäjä KM, 2012, CIRCULATION, V126, P2473, DOI 10.1161/CIRCULATIONAHA.112.120410
   Manalo IF, 2015, J AM ACAD DERMATOL, V73, P872, DOI 10.1016/j.jaad.2015.07.029
   Margolis D, 2001, ARCH DERMATOL, V137, P778
   Margolis DJ, 2011, BRIT J DERMATOL, V165, P930, DOI 10.1111/j.1365-2133.2011.10652.x
   Mariette X, 2011, ANN RHEUM DIS, V70, P1895, DOI 10.1136/ard.2010.149419
   Maybury CM, 2014, BRIT J DERMATOL, V170, P1237, DOI 10.1111/bjd.12905
   Mehta NN, 2012, J AM ACAD DERMATOL, V67, P796, DOI 10.1016/j.jaad.2012.05.016
   Mehta NN, 2012, JOVE-J VIS EXP, DOI 10.3791/3777
   Menter A, 2008, J AM ACAD DERMATOL, V58, P826, DOI 10.1016/j.jaad.2008.02.039
   Micha R, 2011, AM J CARDIOL, V108, P1362, DOI 10.1016/j.amjcard.2011.06.054
   Motaparthi K, 2014, J AM ACAD DERMATOL, V70, P178, DOI 10.1016/j.jaad.2013.08.049
   Moyer VA, 2014, ANN INTERN MED, V160, P330, DOI 10.7326/M13-2771
   Moyer VA, 2012, ANN INTERN MED, V156, P880, DOI 10.7326/0003-4819-156-12-201206190-00424
   Nathan DM, 2006, J GASTROEN HEPATOL, V21, P1366, DOI 10.1111/j.1440-1746.2006.04559.x
   Ogdie A, 2015, RHEUM DIS CLIN N AM, V41, P545, DOI 10.1016/j.rdc.2015.07.001
   Parsi KK, 2012, J AM ACAD DERMATOL, V67, P357, DOI 10.1016/j.jaad.2011.09.006
   Peters MJL, 2010, ANN RHEUM DIS, V69, P325, DOI 10.1136/ard.2009.113696
   Pouplard C, 2013, J EUR ACAD DERMATOL, V27, P36, DOI 10.1111/jdv.12165
   Prodanowich S, 2005, J AM ACAD DERMATOL, V52, P262, DOI 10.1016/j.jaad.2004.06.017
   Puig L, 2011, J EUR ACAD DERMATOL, V25, P1007, DOI 10.1111/j.1468-3083.2011.04065.x
   Raaschou P, 2013, BMJ, V346, pf1939
   Ridker PM, 2009, J THROMB HAEMOST, V7, P332, DOI 10.1111/j.1538-7836.2009.03404.x
   Ritchlin CT, 2009, ANN RHEUM DIS, V68, P1387, DOI 10.1136/ard.2008.094946
   Rosenberg P, 2007, J HEPATOL, V46, P1111, DOI 10.1016/j.jhep.2007.01.024
   Rosmarin DM, 2010, J AM ACAD DERMATOL, V62, P838, DOI 10.1016/j.jaad.2009.05.017
   Roubille C, 2015, ANN RHEUM DIS, V74, P480, DOI 10.1136/annrheumdis-2014-206624
   Shalom G, 2015, JAMA DERMATOL, V151, P533, DOI 10.1001/jamadermatol.2014.4956
   Singh JA, 2012, ARTHRIT CARE RES, V64, P625, DOI 10.1002/acr.21641
   Siu AL, 2015, ANN INTERN MED, V163, P778, DOI 10.7326/M15-2223
   Smith CH, 2009, BRIT J DERMATOL, V161, P987, DOI 10.1111/j.1365-2133.2009.09505.x
   Stern RS, 1998, ARCH DERMATOL, V134, P1582, DOI 10.1001/archderm.134.12.1582
   Strangfeld A, 2010, ARTHRITIS RES THER, V12, DOI 10.1186/ar2904
   Strikas RA, 2015, MMWR-MORBID MORTAL W, V64, P93
   Takeshita J, 2016, J INVEST DERMATOL, V136, pS34, DOI 10.1016/j.jid.2016.02.219
   Takeshita J, 2015, J INVEST DERMATOL, V135, pS50
   Takeshita J, 2015, JAMA DERMATOL, V151, P161, DOI 10.1001/jamadermatol.2014.2094
   Tubach F, 2009, ARTHRITIS RHEUM-US, V60, P1884, DOI 10.1002/art.24632
   Upala S, 2015, INT J OBESITY, V39, P1197, DOI 10.1038/ijo.2015.64
   VAHLQUIST C, 1988, ACTA DERM-VENEREOL, V68, P300
   Wakkee M, 2011, J AM ACAD DERMATOL, V65, P1135, DOI 10.1016/j.jaad.2010.08.036
   Wan J, 2013, BMJ-BRIT MED J, V347, DOI 10.1136/bmj.f5961
   Weinbaum Cindy M., 2008, Morbidity and Mortality Weekly Report, V57, P1, DOI 10.1002/hep.22882
   Wine-Lee L, 2013, J AM ACAD DERMATOL, V69, P1003, DOI 10.1016/j.jaad.2013.06.046
   Wu JJ, 2012, ARCH DERMATOL, V148, P1244, DOI 10.1001/archdermatol.2012.2502
   Yeung H, 2013, JAMA DERMATOL, V149, P1173, DOI 10.1001/jamadermatol.2013.5015
NR 99
TC 151
Z9 160
U1 0
U2 12
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0190-9622
J9 J AM ACAD DERMATOL
JI J. Am. Acad. Dermatol.
PD MAR
PY 2017
VL 76
IS 3
BP 393
EP 403
DI 10.1016/j.jaad.2016.07.065
PG 11
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA ES0KG
UT WOS:000399214700011
PM 28212760
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Dogaru, G
   Bulboaca, AE
   Gheban, D
   Boarescu, PM
   Rus, V
   Festila, D
   Sitar-Taut, AV
   Stanescu, I
AF Dogaru, Gabriela
   Bulboaca, Adriana Elena
   Gheban, Dan
   Boarescu, Paul Mihai
   Rus, Vasile
   Festila, Dana
   Sitar-Taut, Adela-Viviana
   Stanescu, Ioana
TI Effect of Liposomal Curcumin on Acetaminophen Hepatotoxicity by
   Down-regulation of Oxidative Stress and Matrix Metalloproteinases
SO IN VIVO
LA English
DT Article
DE Curcumin; acetaminophen-induced hepatotoxicity; tumor necrosis factor
   alpha; oxidative stress; matrix metalloproteinases
ID HEPATIC MICROVASCULAR INJURY; LIVER-INJURY; METABOLIC SYNDROME;
   IN-VITRO; NECROSIS; ISCHEMIA; PROTECTS; INHIBITION; ALPHA; REGENERATION
AB Background/Aim: The hepatoprotective role of various molecules in drug-induced hepatotoxicity arouses great interest. We investigated the effect of liposomal curcumin (LCC) on experimental acetaminophen (APAP)-induced hepatotoxicity. Materials and Methods: Rats were randomly allocated into 5 groups, and the effect of two LCC concentrations was studied: group 1 - 1 ml intraperitoneal (i.p.) saline, group 2 - APAP pretreatment, group 3 - APAP+silymarin (extract of the silybum marianum with anti-inflammatory, anti-oxidant, and anti-fibrotic properties), group 4 - APAP+LCC1, group 5 - APAP+LCC2. The biomarkers of oxidative stress (nitric oxide and malondialdehyde) and antioxidant status of plasma (thiols and catalase), TNF-alpha, MMP-2 and MMP-9 serum levels were evaluated. Results: An improvement in oxidative stress, antioxidant status, and TNF-alpha, MMP-2 and MMP-9 levels was obtained in groups pretreated with LCC compared to silymarin treatment, in a dose-dependent manner. Histopathological examination reinforced the results. Conclusion: Liposomal curcumin improves the oxidative stress/antioxidant balance and alleviates inflammation in experimental APAP-induced hepatotoxicity.
C1 [Dogaru, Gabriela] Iuliu Hatieganu Univ Med & Pharm, Dept Med Rehabil, Cluj Napoca, Romania.
   [Bulboaca, Adriana Elena; Boarescu, Paul Mihai] Iuliu Hatieganu Univ Med & Pharm, Dept Pathophysiol, Cluj Napoca, Romania.
   [Gheban, Dan] Iuliu Hatieganu Univ Med & Pharm, Dept Pathol Anat, Cluj Napoca, Romania.
   [Rus, Vasile] Univ Agr Sci & Vet Med, Dept Cell Biol Histol & Embryol, Calea Manastur Str 3-5, Cluj Napoca 400375, Romania.
   [Festila, Dana] Iuliu Hatieganu Univ Med & Pharm, Dept Orthodont, Cluj Napoca, Romania.
   [Sitar-Taut, Adela-Viviana] Iuliu Hatieganu Univ Med & Pharm, Dept Internal Med, Cluj Napoca, Romania.
   [Stanescu, Ioana] Iuliu Hatieganu Univ Med & Pharm, Dept Neurol, Cluj Napoca, Romania.
C3 Iuliu Hatieganu University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy; Iuliu Hatieganu University of
   Medicine & Pharmacy; University of Agricultural Sciences & Veterinary
   Medicine Cluj Napoca; Iuliu Hatieganu University of Medicine & Pharmacy;
   Iuliu Hatieganu University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy
RP Rus, V (corresponding author), Univ Agr Sci & Vet Med, Dept Cell Biol Histol & Embryol, Calea Manastur Str 3-5, Cluj Napoca 400375, Romania.
EM vasile.rus@usamvcluj.ro
RI Bulboacă, Adriana-Elena/AAD-7347-2020; Rus, Vasile/HAL-6488-2022;
   Gheban, Dan/AEM-1332-2022; STANESCU, IOANA CRISTINA/JVZ-1768-2024;
   Boarescu, Paul/S-2448-2017; Festila, Dana/AEO-5262-2022; Adriana-Elena,
   Bulboaca/S-8093-2017
OI Dan, Gheban/0000-0002-0755-2882; Adriana-Elena,
   Bulboaca/0000-0001-7748-382X; Rus, Vasile/0000-0003-3706-887X; STANESCU,
   IOANA CRISTINA/0000-0003-0613-9575
CR AEBI H, 1984, METHOD ENZYMOL, V105, P121
   Al-Olayan E, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/381413
   Almazroo OA, 2017, CLIN LIVER DIS, V21, P1, DOI 10.1016/j.cld.2016.08.001
   Alvarenga DM, 2018, CELLS-BASEL, V7, DOI 10.3390/cells7120247
   ARAI K, 1990, ANNU REV BIOCHEM, V59, P783, DOI 10.1146/annurev.bi.59.070190.004031
   Athersuch TJ, 2018, TOXICOL RES-UK, V7, P347, DOI 10.1039/c7tx00340d
   Attia H, 2016, BMC COMPLEM ALTERN M, V16, DOI 10.1186/s12906-016-1388-2
   Bhushan Bharat, 2016, Gene Expression, V17, P35, DOI 10.3727/105221616X691578
   Blazka ME, 1996, TOXICOL PATHOL, V24, P181, DOI 10.1177/019262339602400206
   Boarescu PM, 2019, MOLECULES, V24, DOI 10.3390/molecules24152802
   Boarescu PM, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/7847142
   Bulboaca A, 2016, IRAN J BASIC MED SCI, V19, P585
   Bulboaca AE, 2019, MED SCI MONITOR, V25, P5087, DOI 10.12659/MSM.915607
   Bulboaca AE, 2018, INT J NANOMED, V13, P3093, DOI 10.2147/IJN.S162087
   Bulboaca AE, 2019, MOLECULES, V24, DOI 10.3390/molecules24050846
   Bunchorntavakul C, 2013, CLIN LIVER DIS, V17, P587, DOI 10.1016/j.cld.2013.07.005
   Caro AA, 2005, BIOCHEM PHARMACOL, V69, P1081, DOI 10.1016/j.bcp.2005.01.007
   Chen Q, 2017, NUTRIENTS, V9, DOI 10.3390/nu9020096
   Chiu H, 2003, AM J PHYSIOL-GASTR L, V285, pG959, DOI 10.1152/ajpgi.00219.2003
   Cursio R, 2001, FASEB J, V15, P93, DOI 10.1096/fj.01-0279fje
   Defamie V, 2008, HEPATOLOGY, V47, P177, DOI 10.1002/hep.21929
   Demine S, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8080795
   Du K, 2017, FOOD CHEM TOXICOL, V108, P339, DOI 10.1016/j.fct.2017.08.020
   Duarte S, 2015, MATRIX BIOL, V44-46, P147, DOI 10.1016/j.matbio.2015.01.004
   Fadda L, 2019, TOXICOL REP, V6, P712, DOI 10.1016/j.toxrep.2019.07.008
   Feng T, 2017, INT J NANOMED, V12, P6027, DOI 10.2147/IJN.S132434
   Gardner CR, 2012, TOXICOL APPL PHARM, V262, P139, DOI 10.1016/j.taap.2012.04.027
   Gera M, 2017, ONCOTARGET, V8, P66680, DOI 10.18632/oncotarget.19164
   Grober Uwe, 2012, Med Monatsschr Pharm, V35, P445
   GUENGERICH FP, 1985, CRC CR REV TOXICOL, V14, P259, DOI 10.3109/10408448509037460
   Gupta SC, 2013, AAPS J, V15, P195, DOI 10.1208/s12248-012-9432-8
   Hamada T, 2008, HEPATOLOGY, V47, P186, DOI 10.1002/hep.21922
   Hamano N, 2019, MOL PHARMACEUT, V16, P3957, DOI 10.1021/acs.molpharmaceut.9b00583
   Hammam Olfat, 2013, Gastrointest Cancer Res, V6, P107
   Heritage Mandy, 2017, World J Gastrointest Pathophysiol, V8, P67, DOI 10.4291/wjgp.v8.i2.67
   Hu JN, 2017, MOLECULES, V22, DOI 10.3390/molecules22040664
   HU ML, 1994, METHOD ENZYMOL, V233, P380
   Ito Y, 2005, TOXICOL SCI, V83, P190, DOI 10.1093/toxsci/kfh291
   Ito Y, 2004, AM J PHYSIOL-GASTR L, V286, pG60, DOI 10.1152/ajpgi.00217.2003
   Jaeschke H, 2018, FOOD CHEM TOXICOL, V118, P709, DOI 10.1016/j.fct.2018.06.025
   JANERO DR, 1990, FREE RADICAL BIO MED, V9, P515, DOI 10.1016/0891-5849(90)90131-2
   Jazayeri-Tehrani SA, 2017, BMJ OPEN, V7, DOI 10.1136/bmjopen-2017-016914
   Jurenka JS, 2009, ALTERN MED REV, V14, P141
   Kato H, 2014, J HEPATOL, V60, P1032, DOI 10.1016/j.jhep.2013.12.022
   Kelany ME, 2017, CAN J PHYSIOL PHARM, V95, P140, DOI 10.1139/cjpp-2016-0152
   Kwon KW, 2019, KOREAN J PHYSIOL PHA, V23, P263, DOI 10.4196/kjpp.2019.23.4.263
   Mazer M, 2008, J MED TOXICOL, V4, P2, DOI 10.1007/BF03160941
   McGill MR, 2013, PHARM RES-DORDR, V30, P2174, DOI 10.1007/s11095-013-1007-6
   Melo A, 2016, FRONT BEHAV NEUROSCI, V10, DOI 10.3389/fnbeh.2016.00226
   MITCHELL JR, 1973, J PHARMACOL EXP THER, V187, P211
   MOCHIDA S, 1989, J PATHOL, V158, P67, DOI 10.1002/path.1711580113
   Mohammadi A, 2019, J NUTR BIOCHEM, V66, P1, DOI 10.1016/j.jnutbio.2018.12.005
   Morsy MA, 2012, J PHYSIOL BIOCHEM, V68, P29, DOI 10.1007/s13105-011-0116-0
   Mouzaoui S, 2012, INT IMMUNOPHARMACOL, V12, P302, DOI 10.1016/j.intimp.2011.10.010
   Murthy A, 2012, J IMMUNOL, V188, P2876, DOI 10.4049/jimmunol.1102199
   Nafady Allam Mohamed, 2017, J Microsc Ultrastruct, V5, P21, DOI 10.1016/j.jmau.2016.04.003
   Parks WC, 2004, NAT REV IMMUNOL, V4, P617, DOI 10.1038/nri1418
   Ramachandran Anup, 2018, J Clin Transl Res, V4, P75
   Ramachandran A, 2013, HEPATOLOGY, V58, P2099, DOI 10.1002/hep.26547
   Shehzad A, 2017, J FOOD SCI, V82, P2006, DOI 10.1111/1750-3841.13793
   Somchit M, 2014, ASIAN PAC J CANCER P, V15, P1807, DOI 10.7314/APJCP.2014.15.4.1807
   Sreejayan N, 1996, ARZNEIMITTEL-FORSCH, V46, P169
   Subramanya SB, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19123776
   Tefas LR, 2017, DRUG DES DEV THER, V11, P1605, DOI 10.2147/DDDT.S129008
   Trettin A, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/212576
   Trivedi MK, 2017, INFLAMMOPHARMACOLOGY, V25, P609, DOI 10.1007/s10787-017-0395-3
   Tsikas D, 2007, J CHROMATOGR B, V851, P51, DOI 10.1016/j.jchromb.2006.07.054
   Uchida NS, 2017, EVID-BASED COMPL ALT, V2017, DOI 10.1155/2017/1796209
   Viappiani S, 2006, CURR PHARM DESIGN, V12, P2923, DOI 10.2174/138161206777947560
   Wang XY, 2005, J CONTROL RELEASE, V104, P91, DOI 10.1016/j.jconrel.2005.01.008
   Yan MZ, 2018, REDOX BIOL, V17, P274, DOI 10.1016/j.redox.2018.04.019
   Yan TT, 2016, DRUG METAB DISPOS, V44, P720, DOI 10.1124/dmd.116.069419
   Yang X, 2013, J PHARMACOL EXP THER, V344, P286, DOI 10.1124/jpet.112.199067
   Yu HL, 2011, FOOD FUNCT, V2, P373, DOI 10.1039/c1fo10053j
   Zakaria ZA, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1781-5
   Zbodakova O., 2017, Metalloproteinases Med, V4, P25, DOI [10.2147/MNM.S124363, DOI 10.2147/MNM.S124363, 10.2147/mnm.s124363]
   Zhang JF, 2018, J ANIM SCI, V96, P867, DOI 10.1093/jas/sky009
   Zhong S, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000009061
   Zhong Y, 2017, MOL MED REP, V16, P4315, DOI 10.3892/mmr.2017.7037
NR 79
TC 19
Z9 20
U1 1
U2 11
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22,
   ATHENS 19014, GREECE
SN 0258-851X
EI 1791-7549
J9 IN VIVO
JI In Vivo
PD MAR-APR
PY 2020
VL 34
IS 2
BP 569
EP 582
DI 10.21873/invivo.11809
PG 14
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA KS2ML
UT WOS:000518144400012
PM 32111755
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Luger, M
   Kruschitz, R
   Marculescu, R
   Haslacher, H
   Hoppichler, F
   Kallay, E
   Kienbacher, C
   Klammer, C
   Kral, M
   Langer, F
   Luger, E
   Prager, G
   Trauner, M
   Traussnigg, S
   Würger, T
   Schindler, K
   Ludvik, B
AF Luger, Maria
   Kruschitz, Renate
   Marculescu, Rodrig
   Haslacher, Helmuth
   Hoppichler, Friedrich
   Kallay, Enikoe
   Kienbacher, Christian
   Klammer, Carmen
   Kral, Melanie
   Langer, Felix
   Luger, Eva
   Prager, Gerhard
   Trauner, Michael
   Traussnigg, Stefan
   Wuerger, Tanja
   Schindler, Karin
   Ludvik, Bernhard
TI The link between obesity and vitamin D in bariatric patients with
   omega-loop gastric bypass surgery - a vitamin D supplementation trial to
   compare the efficacy of postoperative cholecalciferol loading (LOAD):
   study protocol for a randomized controlled trial
SO TRIALS
LA English
DT Article
DE Bariatric patients; Cholecalciferol; Obesity; Vitamin D; Vitamin D
   supplementation trial
ID FATTY LIVER-DISEASE; QUALITY-OF-LIFE; D DEFICIENCY; NUTRITIONAL
   DEFICIENCIES; METABOLIC SYNDROME; NONALCOHOLIC STEATOHEPATITIS;
   MORBID-OBESITY; WEIGHT-LOSS; D-RECEPTOR; DEPRESSION
AB Background: Beyond its classical role in calcium homoeostasis and bone metabolism, vitamin D deficiency has been found to be associated with several diseases, including diabetes, non-alcoholic fatty liver disease, and even obesity itself. Importantly, there are limited data on therapeutic strategies for vitamin D deficiency in bariatric patients, and the procedure-specific guidelines may not be sufficient. To improve long-term outcomes, nutritional screening and appropriate supplementation to prevent nutrient deficiencies are urgently needed. Therefore, the aim of this study is to examine effects and safety of a forced dosing regimen of vitamin D versus conventional dose supplementation on vitamin D levels and other parameters in bariatric patients.
   Methods/Design: The study includes loading plus repeat dosing compared with repeated administration of vitamin D without a loading dose, according to guidelines, in a prospective, double-blind, randomized controlled trial. Up to a triple oral loading dose is given on day 1, then 2 and 4 weeks after surgery (100,000 IU dose each time), followed by an oral maintenance dose (3420 IU/day). The control group (n = 25) will receive placebo, followed by administration of a standard dose (3420 IU/day). We hypothesize that a significant increase in vitamin D levels will occur in patients in the treatment group (n = 25) by 24 weeks after surgery. Further measurements are aimed at evaluating changes in inflammation, bone turnover, insulin resistance, blood pressure, liver, mental health, and gut microbiota of patients undergoing omega-loop gastric bypass surgery. Furthermore, possible associations between concentrations of vitamin D, the involved enzymes, or vitamin D receptor in adipose and/or liver tissues will be determined.
   Discussion: To our knowledge, this trial is the first of its kind with this type of vitamin D supplementation in bariatric patients. Its major strength is the design and implementation of evaluation of influencing factors such as liver function, bone health, inflammation, insulin resistance, blood pressure, symptoms of depression, or microbiota. This alternative vitamin D dosing regimen has the potential to be a safe, fast, evidence-based treatment of vitamin D deficiency in bariatric patients. Owing to the increasing number of bariatric patients, it is also of interest to elucidate the link between obesity and vitamin D.
C1 [Luger, Maria; Kruschitz, Renate; Klammer, Carmen; Schindler, Karin; Ludvik, Bernhard] Med Univ Vienna, Dept Internal Med 3, Div Endocrinol & Metab, A-1090 Vienna, Austria.
   [Luger, Maria; Hoppichler, Friedrich] SIPCAN, A-5026 Salzburg, Austria.
   [Marculescu, Rodrig; Haslacher, Helmuth] Med Univ Vienna, Dept Lab Med, Clin Inst Med & Chem Lab Diagnost, A-1090 Vienna, Austria.
   [Kallay, Enikoe] Med Univ Vienna, Dept Pathophysiol & Allergy Res, A-1090 Vienna, Austria.
   [Kienbacher, Christian; Kral, Melanie; Trauner, Michael; Traussnigg, Stefan] Med Univ Vienna, Dept Internal Med 3, Div Gastroenterol & Hepatol, A-1090 Vienna, Austria.
   [Langer, Felix; Prager, Gerhard] Med Univ Vienna, Dept Surg, Div Gen Surg, A-1090 Vienna, Austria.
   [Luger, Eva] Med Univ Vienna, Ctr Publ Hlth, Inst Social Med, A-1090 Vienna, Austria.
   [Wuerger, Tanja] Med Univ Vienna, Dept Pathol, A-1090 Vienna, Austria.
C3 Medical University of Vienna; Medical University of Vienna; Medical
   University of Vienna; Medical University of Vienna; Medical University
   of Vienna; Medical University of Vienna; Medical University of Vienna
RP Schindler, K (corresponding author), Med Univ Vienna, Dept Internal Med 3, Div Endocrinol & Metab, Wahringer Gurtel 18-20, A-1090 Vienna, Austria.
EM karin.schindler@meduniwien.ac.at
RI Trauner, Michael/HCH-4032-2022; Marculescu, Rodrig/B-6474-2016;
   Haslacher, Helmuth/D-4233-2013
OI Trauner, Michael/0000-0002-1275-6425; Marculescu,
   Rodrig/0000-0003-1772-6695; Wakolbinger, Maria/0000-0002-1991-6700;
   Haslacher, Helmuth/0000-0003-4605-2503; Winzer, Eva/0000-0002-5547-8517;
   Kallay, Eniko/0000-0002-4996-0104
CR Aasheim ET, 2008, AM J CLIN NUTR, V87, P362, DOI 10.1093/ajcn/87.2.362
   Aasheim ET, 2009, AM J CLIN NUTR, V90, P15, DOI 10.3945/ajcn.2009.27583
   Agostoni C, 2012, EFSA J, V10, DOI 10.2903/j.efsa.2012.2813
   Amrein K, 2014, JAMA-J AM MED ASSOC, V312, P1520, DOI 10.1001/jama.2014.13204
   Martínez-González MA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043134
   Anglin RES, 2013, BRIT J PSYCHIAT, V202, P100, DOI 10.1192/bjp.bp.111.106666
   [Anonymous], 2013, ISRN OBES
   [Anonymous], VITAMIN D
   [Anonymous], AM J PHYSL ENDOCRINO
   [Anonymous], MED STAT INF
   Artaza JN, 2009, CLIN J AM SOC NEPHRO, V4, P1515, DOI 10.2215/CJN.02260409
   Bacci V, 2010, EXPERT REV GASTROENT, V4, P781, DOI [10.1586/egh.10.69, 10.1586/EGH.10.69]
   Bacon CJ, 2009, OSTEOPOROSIS INT, V20, P1407, DOI 10.1007/s00198-008-0814-9
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   BELL NH, 1985, J CLIN INVEST, V76, P370, DOI 10.1172/JCI111971
   Bellia A, 2013, INTERN EMERG MED, V8, P33, DOI 10.1007/s11739-011-0559-x
   Blachier M, 2013, J HEPATOL, V58, P593, DOI 10.1016/j.jhep.2012.12.005
   Botella-Carretero JI, 2007, CLIN NUTR, V26, P573, DOI 10.1016/j.clnu.2007.05.009
   Buchwald H, 2009, OBES SURG, V19, P1605, DOI 10.1007/s11695-009-0014-5
   Bugianesi E, 2002, GASTROENTEROLOGY, V123, P134, DOI 10.1053/gast.2002.34168
   Chalasani N, 2012, GASTROENTEROLOGY, V142, P1592, DOI 10.1053/j.gastro.2012.04.001
   Charlton MR, 2011, GASTROENTEROLOGY, V141, P1249, DOI 10.1053/j.gastro.2011.06.061
   Ching S, 2011, J CELL BIOCHEM, V112, P3393, DOI 10.1002/jcb.23273
   Cipriani C, 2010, J CLIN ENDOCR METAB, V95, P4771, DOI 10.1210/jc.2010-0502
   Clements RH, 2008, AM SURGEON, V74, P469
   Csendes A, 2006, OBES SURG, V16, P607, DOI 10.1381/096089206776944904
   Dale O, 1996, ACTA ANAESTH SCAND, V40, P771, DOI 10.1111/j.1399-6576.1996.tb04530.x
   Ducloux R, 2011, OBES SURG, V21, P556, DOI 10.1007/s11695-010-0352-3
   Eliades M, 2013, ALIMENT PHARM THER, V38, P246, DOI 10.1111/apt.12377
   Fish E, 2010, J SURG RES, V164, P198, DOI 10.1016/j.jss.2010.06.029
   Foss YJ, 2009, MED HYPOTHESES, V72, P314, DOI 10.1016/j.mehy.2008.10.005
   Gagnon LE, 2012, AM J NURS, V112, P26, DOI 10.1097/01.NAJ.0000418920.45600.7a
   Gasteyger C, 2008, AM J CLIN NUTR, V87, P1128, DOI 10.1093/ajcn/87.5.1128
   George N, 2012, BRIT J NUTR, V108, P1410, DOI 10.1017/S0007114511006830
   Gloth F M 3rd, 1999, J Nutr Health Aging, V3, P5
   Goldner WS, 2009, OBES SURG, V19, P173, DOI 10.1007/s11695-008-9680-y
   Johnson JM, 2006, ANN SURG, V243, P701, DOI 10.1097/01.sla.0000216773.47825.c1
   Jorde R, 2008, J INTERN MED, V264, P599, DOI 10.1111/j.1365-2796.2008.02008.x
   KAMEI Y, 1993, BIOCHEM BIOPH RES CO, V193, P948, DOI 10.1006/bbrc.1993.1717
   Kayaniyil S, 2011, J CLIN ENDOCR METAB, V96, P168, DOI 10.1210/jc.2010-1439
   Kenakin T, 2009, PHARMACOLOGY PRIMER: THEORY, APPLICATIONS, AND METHODS, 3RD EDITION, P179, DOI 10.1016/B978-0-12-374585-9.00009-8
   Kjærgaard M, 2012, BRIT J PSYCHIAT, V201, P360, DOI 10.1192/bjp.bp.111.104349
   Kolotkin RL, 2009, SURG OBES RELAT DIS, V5, P250, DOI 10.1016/j.soard.2009.01.009
   Kyle UG, 2004, CLIN NUTR, V23, P1226, DOI 10.1016/j.clnu.2004.06.004
   Lazo M, 2008, SEMIN LIVER DIS, V28, P339, DOI 10.1055/s-0028-1091978
   Ledoux S, 2008, AM J CLIN NUTR, V88, P1176, DOI 10.1093/ajcn/88.4.1176
   Li J, 2008, J STEROID BIOCHEM, V112, P122, DOI 10.1016/j.jsbmb.2008.09.006
   Luger M, 2015, OBES SURG, V25, P1056, DOI 10.1007/s11695-014-1492-7
   Machado M, 2006, J HEPATOL, V45, P600, DOI 10.1016/j.jhep.2006.06.013
   Mathus-Vliegen EMH, 2007, BRIT J SURG, V94, P457, DOI 10.1002/bjs.5607
   Matteoni CA, 1999, GASTROENTEROLOGY, V116, P1413, DOI 10.1016/S0016-5085(99)70506-8
   MAWER EB, 1972, CLIN SCI, V43, P413, DOI 10.1042/cs0430413
   Mechanick JI, 2013, ENDOCR PRACT, V19, P338
   Mechanick JI, 2010, OBESITY, V18, P649
   Mechanick Jeffrey I, 2008, Endocr Pract, V14 Suppl 1, P1
   Moher D, 2010, BMJ-BRIT MED J, V340, DOI [10.1016/j.jclinepi.2010.02.005, 10.1136/bmj.c869, 10.1186/1741-7015-8-18, 10.1016/j.ijsu.2011.10.001, 10.1136/bmj.c332, 10.4103/0976-500X.72352, 10.1186/1745-6215-11-32, 10.1016/j.jclinepi.2010.03.004]
   Naalt SJV, 2014, HEPATIC MED-EVID RES, V6, P103, DOI 10.2147/HMER.S64819
   Osei K, 2010, J CLIN ENDOCR METAB, V95, P4220, DOI 10.1210/jc.2010-1550
   Ozfirat Z, 2010, POSTGRAD MED J, V86, P18, DOI 10.1136/pgmj.2009.078626
   Pilone V, 2012, SURG OBES RELAT DIS, V8, P260, DOI 10.1016/j.soard.2011.12.012
   Popkin BM, 2010, AM J CLIN NUTR, V91, p284S, DOI 10.3945/ajcn.2009.28473C
   Potter JJ, 2013, LIVER INT, V33, P677, DOI 10.1111/liv.12122
   Roth CL, 2012, HEPATOLOGY, V55, P1103, DOI 10.1002/hep.24737
   Sasaki A, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00164
   Schmitt M, 2006, DIAGNOSTICA, V52, P51, DOI 10.1026/0012-1924.52.2.51
   Signori C, 2010, OBES SURG, V20, P949, DOI 10.1007/s11695-010-0178-z
   Sjöström L, 2007, NEW ENGL J MED, V357, P741, DOI 10.1056/NEJMoa066254
   Skroubis G, 2002, OBES SURG, V12, P551, DOI 10.1381/096089202762252334
   Sovik TT, 2011, ANN INTERN MED, V155, P281, DOI 10.7326/0003-4819-155-5-201109060-00005
   Starmann J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046584
   Tucker ON, 2007, MED CLIN N AM, V91, P499, DOI 10.1016/j.mcna.2007.01.006
   Vieth R, 1999, AM J CLIN NUTR, V69, P842
   Vieth R, 2007, J BONE MINER RES, V22, pV64, DOI 10.1359/JBMR.07S221
   Wang TT, 2005, MOL ENDOCRINOL, V19, P2685, DOI 10.1210/me.2005-0106
   Wang YF, 2008, OBESITY, V16, P2323, DOI 10.1038/oby.2008.351
   Wong KE, 2011, J BIOL CHEM, V286, P33804, DOI 10.1074/jbc.M111.257568
   Wortsman J, 2000, AM J CLIN NUTR, V72, P690, DOI 10.1093/ajcn/72.3.690
   Wree A, 2014, METABOLISM, V63, P1542, DOI 10.1016/j.metabol.2014.09.001
   Yach D, 2006, NAT MED, V12, P62, DOI 10.1038/nm0106-62
   ZAROWITZ BJ, 1989, DICP ANN PHARMAC, V23, P548, DOI 10.1177/1060028089023007-803
   Zhang AB, 2007, INT IMMUNOPHARMACOL, V7, P1122, DOI 10.1016/j.intimp.2007.03.007
   Ziegler O, 2009, DIABETES METAB, V35, P544, DOI 10.1016/S1262-3636(09)73464-0
NR 82
TC 11
Z9 11
U1 1
U2 22
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD AUG 5
PY 2015
VL 16
AR 328
DI 10.1186/s13063-015-0877-9
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CO1MX
UT WOS:000358920600001
PM 26242295
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Garg, A
   Naik, HB
   Kirby, JS
AF Garg, Amit
   Naik, Haley B.
   Kirby, Joslyn S.
TI A Practical Guide for Primary Care Providers on Timely Diagnosis and
   Comprehensive Care Strategies for Hidradenitis Suppurativa
SO AMERICAN JOURNAL OF MEDICINE
LA English
DT Review
DE Hidradenitis suppurativa; HS clinical presentation; HS management;
   Primary care provider
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; PAIN MANAGEMENT; DISEASE;
   PREVALENCE; DEPRESSION; HEALTH; BURDEN; RISK; SEVERITY
AB Hidradenitis suppurativa is a chronic, progressive inflammatory disease of the skin with many systemic implications. Hidradenitis suppurativa is frequently underdiagnosed or misdiagnosed, particularly because of heterogeneity in presentation and low disease recognition. Patients can see multiple types of health care providers, including primary care providers, along their journey to an accurate diagnosis. This review provides a comprehensive overview of the clinical presentation, associated comorbidities, and life impact associated with hidradenitis suppurativa. Disease features described here can facilitate earlier identification of hidradenitis suppurativa, differentiation from common mimickers, and timely referrals for multidisciplinary management when needed. Engagement of the medical community will also support comprehensive care strategies necessary in hidradenitis suppurativa.
C1 [Garg, Amit] Donald & Barbara Zucker Sch Med Hofstra Northwell, New Hyde Pk, NY USA.
   [Naik, Haley B.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Kirby, Joslyn S.] Penn State Hlth Dermatol, Hershey, PA USA.
C3 Northwell Health; University of California System; University of
   California San Francisco
RP Garg, A (corresponding author), Donald & Barbara Zucker Sch Med Hofstra Northwell, Dept Dermatol, 1991 Marcus Ave,Suite 300, New Hyde Pk, NY 11042 USA.
EM amgarg@Northwell.edu
RI Garg, Amit/JEO-9043-2023
OI Garg, Amit/0000-0003-0886-6856
FU Novartis Pharmaceuticals Corporation
FX Medical writing support was provided by Charli Dominguez, PhD, CMPP, of
   Health Interactions, Inc, Chicago, IL, and was funded by Novartis
   Pharmaceuticals Corporation. This manuscript was developed in accordance
   with Good Publication Practice (GPP3) guidelines. Authors had full
   control of the content and made the final decision on all aspects of
   this publication.
CR Alavi A, 2018, Int J Womens Dermatol, V4, P74, DOI 10.1016/j.ijwd.2017.10.007
   Alavi A, 2015, J AM ACAD DERMATOL, V73, pS55, DOI 10.1016/j.jaad.2015.07.048
   Alikhan A, 2019, J AM ACAD DERMATOL, V81, P76, DOI 10.1016/j.jaad.2019.02.067
   Alikhan A, 2019, J AM ACAD DERMATOL, V81, P91, DOI 10.1016/j.jaad.2019.02.068
   [Anonymous], 2019, CIRCULATION, DOI DOI 10.1161/CIR.0000000000000659
   Blok JL, 2016, BRIT J DERMATOL, V174, P839, DOI 10.1111/bjd.14338
   Bush K, 1998, ARCH INTERN MED, V158, P1789, DOI 10.1001/archinte.158.16.1789
   Casseres RG, 2020, J AM ACAD DERMATOL, V82, P1524, DOI 10.1016/j.jaad.2020.02.005
   Del Duca E, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21228436
   Delage M, 2023, J AM ACAD DERMATOL, V88, P94, DOI 10.1016/j.jaad.2020.01.007
   Desai N, 2017, BRIT J DERMATOL, V176, P1048, DOI 10.1111/bjd.14976
   Egeberg A, 2017, J INVEST DERMATOL, V137, P1060, DOI 10.1016/j.jid.2016.11.040
   Egeberg A, 2016, JAMA DERMATOL, V152, P429, DOI 10.1001/jamadermatol.2015.6264
   Enamandram M, 2015, J AM ACAD DERMATOL, V73, P575, DOI 10.1016/j.jaad.2014.11.038
   Fauconier M, 2018, JOINT BONE SPINE, V85, P593, DOI 10.1016/j.jbspin.2017.09.005
   Fauser BCJM, 2004, HUM REPROD, V19, P41, DOI 10.1093/humrep/deh098
   Fitzpatrick L, 2022, J AM ACAD DERMATOL, V86, P46, DOI 10.1016/j.jaad.2021.06.023
   Freeman AF, 2009, ORAL DIS, V15, P2, DOI 10.1111/j.1601-0825.2008.01463.x
   Frew JW, 2021, JAMA DERMATOL, V157, P449, DOI 10.1001/jamadermatol.2020.5467
   Garcovich S, 2020, J CLIN MED, V9, DOI 10.3390/jcm9124046
   Garg A, 2018, BRIT J DERMATOL, V178, P709, DOI 10.1111/bjd.15939
   Garg A, 2022, J AM ACAD DERMATOL, V86, P1092, DOI 10.1016/j.jaad.2021.01.059
   Garg A, 2020, J AM ACAD DERMATOL, V82, P366, DOI 10.1016/j.jaad.2019.06.1301
   Garg A, 2018, JAMA DERMATOL, V154, P814, DOI 10.1001/jamadermatol.2018.0878
   Garg A, 2018, J INVEST DERMATOL, V138, P2152, DOI 10.1016/j.jid.2018.04.001
   Garg A, 2018, J AM ACAD DERMATOL, V79, P495, DOI 10.1016/j.jaad.2018.02.053
   Garg A, 2018, J AM ACAD DERMATOL, V79, P71, DOI 10.1016/j.jaad.2018.01.014
   Garg A, 2018, J INVEST DERMATOL, V138, P1288, DOI 10.1016/j.jid.2018.01.009
   Garg A, 2017, JAMA DERMATOL, V153, P760, DOI 10.1001/jamadermatol.2017.0201
   Garg A, 2017, J AM ACAD DERMATOL, V77, P118, DOI 10.1016/j.jaad.2017.02.005
   Glatt S, 2021, JAMA DERMATOL, V157, P1279, DOI 10.1001/jamadermatol.2021.2905
   Gold DA, 2014, J AM ACAD DERMATOL, V70, P699, DOI 10.1016/j.jaad.2013.11.014
   Horváth B, 2015, J AM ACAD DERMATOL, V73, pS47, DOI 10.1016/j.jaad.2015.07.046
   Hotz C, 2016, J INVEST DERMATOL, V136, P1768, DOI 10.1016/j.jid.2016.04.036
   Huang CAM, 2021, J CUTAN MED SURG, V25, P591, DOI 10.1177/12034754211024157
   Huilaja L, 2018, J INVEST DERMATOL, V138, P46, DOI 10.1016/j.jid.2017.06.020
   Humira (adalimumab), HUM AD PACK INS
   Ingram JR, 2018, BRIT J DERMATOL, V178, P917, DOI 10.1111/bjd.16101
   Ingram JR, 2020, BRIT J DERMATOL, V183, P990, DOI 10.1111/bjd.19435
   Janse IC, 2017, BRIT J DERMATOL, V176, P1042, DOI 10.1111/bjd.14975
   Jemec GBE, 2015, J AM ACAD DERMATOL, V73, pS4, DOI 10.1016/j.jaad.2015.07.052
   Join-Lambert O, 2011, DERMATOLOGY, V222, P49, DOI 10.1159/000321716
   Kaaz K, 2018, ACTA DERM-VENEREOL, V98, P757, DOI 10.2340/00015555-2967
   Kanni T, 2018, BRIT J DERMATOL, V179, P413, DOI 10.1111/bjd.16428
   Kelly G, 2015, BRIT J DERMATOL, V173, P1431, DOI 10.1111/bjd.14075
   Khalsa A, 2015, J AM ACAD DERMATOL, V73, P609, DOI 10.1016/j.jaad.2015.06.053
   Khandalavala Birgit N, 2016, J Clin Aesthet Dermatol, V9, P44
   Kimball AB, 2020, J EUR ACAD DERMATOL, V34, P1302, DOI 10.1111/jdv.16132
   Kimball AB, 2016, NEW ENGL J MED, V375, P422, DOI 10.1056/NEJMoa1504370
   Kimball AB, 2018, DERMATOLOGY THER, V8, P557, DOI 10.1007/s13555-018-0264-z
   Kirby JS, 2020, BRIT J DERMATOL, V182, P267, DOI 10.1111/bjd.18707
   Kirby JS, 2014, JAMA DERMATOL, V150, P937, DOI 10.1001/jamadermatol.2014.691
   Kokolakis G, 2020, DERMATOLOGY, V236, P421, DOI 10.1159/000508787
   Koumaki D, 2019, CLIN COSMET INV DERM, V12, P785, DOI 10.2147/CCID.S180036
   Kraft JN, 2007, J CUTAN MED SURG, V11, P125, DOI 10.2310/7750.2007.00019
   Krajewski PK, 2021, ACTA DERM-VENEREOL, V101, DOI 10.2340/00015555-3724
   Kroenke K, 2003, MED CARE, V41, P1284, DOI 10.1097/01.MLR.0000093487.78664.3C
   Kroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.x
   Kromann CB, 2014, BRIT J DERMATOL, V171, P819, DOI 10.1111/bjd.13090
   Kromann CB, 2014, ACTA DERM-VENEREOL, V94, P553, DOI 10.2340/00015555-1800
   Lee JH, 2018, J EUR ACAD DERMATOL, V32, P1784, DOI 10.1111/jdv.15071
   Leslie KS, 2014, J AM ACAD DERMATOL, V70, P243, DOI 10.1016/j.jaad.2013.09.044
   Levis B, 2020, JAMA-J AM MED ASSOC, V323, P2290, DOI 10.1001/jama.2020.6504
   Mac Mahon J, 2020, PATIENT-RELAT OUTCOM, V11, P21, DOI 10.2147/PROM.S174299
   Machado MO, 2019, JAMA DERMATOL, V155, P939, DOI 10.1001/jamadermatol.2019.0759
   Marasca C, 2020, EXPERT REV CLIN PHAR, V13, P521, DOI 10.1080/17512433.2020.1762571
   Marvel J, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2019-030579
   Matusiak L, 2018, ACTA DERM-VENEREOL, V98, P191, DOI 10.2340/00015555-2815
   Miller IM, 2014, JAMA DERMATOL, V150, P1273, DOI 10.1001/jamadermatol.2014.1165
   Mitchell AJ, 2007, BRIT J GEN PRACT, V57, P144
   Montero-Vilchez T, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18136709
   Naik HB, 2020, J INVEST DERMATOL, V140, P922, DOI 10.1016/j.jid.2019.08.445
   Naik HB, 2019, JAMA DERMATOL, V155, P971, DOI 10.1001/jamadermatol.2019.0478
   Napolitano M, 2017, CLIN COSMET INV DERM, V10, P105, DOI 10.2147/CCID.S111019
   Onderdijk AJ, 2013, J EUR ACAD DERMATOL, V27, P473, DOI 10.1111/j.1468-3083.2012.04468.x
   Patel KR, 2019, BRIT J DERMATOL, V181, P275, DOI 10.1111/bjd.17416
   Phan K., 2020, Biomed Dermatol, V4, P1, DOI DOI 10.1186/S41702-019-0052-0
   Pink AE, 2013, J INVEST DERMATOL, V133, P601, DOI 10.1038/jid.2012.372
   Prens E, 2015, J AM ACAD DERMATOL, V73, pS8, DOI 10.1016/j.jaad.2015.07.045
   Prussick L, 2019, BRIT J DERMATOL, V181, P609, DOI 10.1111/bjd.17822
   Reddy S, 2020, JAMA DERMATOL, V156, P65, DOI 10.1001/jamadermatol.2019.3412
   Reddy S, 2019, JAMA DERMATOL, V155, P1284, DOI 10.1001/jamadermatol.2019.2610
   Reddy S, 2019, J AM ACAD DERMATOL, V81, P937, DOI 10.1016/j.jaad.2019.06.016
   Reddy S, 2019, JAMA DERMATOL, V155, P797, DOI 10.1001/jamadermatol.2019.0164
   Revuz JE, 2008, J AM ACAD DERMATOL, V59, P596, DOI 10.1016/j.jaad.2008.06.020
   Riis PT, 2019, BRIT J DERMATOL, V180, P774, DOI 10.1111/bjd.16998
   Riis PT, 2016, ACTA DERMATOVENER CR, V24, P239
   Sabat R, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031810
   Sachdeva M, 2021, J CUTAN MED SURG, V25, P177, DOI 10.1177/1203475420972348
   Savage KT, 2021, J AM ACAD DERMATOL, V85, P187, DOI 10.1016/j.jaad.2020.09.039
   Saylor DK, 2020, DERMATOLOGY THER, V10, P529, DOI 10.1007/s13555-020-00391-x
   Scala E, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10082094
   Schlapbach C, 2011, J AM ACAD DERMATOL, V65, P790, DOI 10.1016/j.jaad.2010.07.010
   Schneider-Burrus S, 2018, JAMA DERMATOL, V154, P447, DOI 10.1001/jamadermatol.2017.6058
   Schrader AMR, 2014, J AM ACAD DERMATOL, V71, P460, DOI 10.1016/j.jaad.2014.04.001
   Sharon VR, 2012, ACTA DERM-VENEREOL, V92, P320, DOI 10.2340/00015555-1229
   Shavit E, 2015, J EUR ACAD DERMATOL, V29, P371, DOI 10.1111/jdv.12567
   Shlyankevich J, 2014, J AM ACAD DERMATOL, V71, P1144, DOI 10.1016/j.jaad.2014.09.012
   Slyper M, 2018, BRIT J DERMATOL, V179, P502, DOI 10.1111/bjd.16483
   Spitzer RL, 2006, ARCH INTERN MED, V166, P1092, DOI 10.1001/archinte.166.10.1092
   Bui TL, 2018, J AM ACAD DERMATOL, V78, P395, DOI 10.1016/j.jaad.2017.08.042
   Theut Riis P, 2016, ACTA DERM-VENEREOL, V96, P222, DOI 10.2340/00015555-2129
   Thomi R, 2018, JAMA DERMATOL, V154, P592, DOI 10.1001/jamadermatol.2018.0141
   Thorlacius L, 2018, J INVEST DERMATOL, V138, P52, DOI 10.1016/j.jid.2017.09.008
   Tiri H, 2018, J INVEST DERMATOL, V138, P2672, DOI 10.1016/j.jid.2018.06.171
   Tzanetakou V, 2016, JAMA DERMATOL, V152, P52, DOI 10.1001/jamadermatol.2015.3903
   Tzellos T, 2015, BRIT J DERMATOL, V173, DOI 10.1111/bjd.14024
   Uebelacker Lisa A, 2011, Prim Care Companion CNS Disord, V13, DOI 10.4088/PCC.10m01027
   van der Zee HH, 2011, BRIT J DERMATOL, V164, P1292, DOI 10.1111/j.1365-2133.2011.10254.x
   Vazquez BG, 2013, J INVEST DERMATOL, V133, P97, DOI 10.1038/jid.2012.255
   Verdolini R, 2013, J EUR ACAD DERMATOL, V27, P1101, DOI 10.1111/j.1468-3083.2012.04668.x
   Vlassova N, 2015, ACTA DERM-VENEREOL, V95, P990, DOI 10.2340/00015555-2176
   von der Werth JM, 2000, J EUR ACAD DERMATOL, V14, P389, DOI 10.1046/j.1468-3083.2000.00087.x
   Vossen ARJV, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.02965
   Vossen ARJV, 2017, AM J CLIN DERMATOL, V18, P687, DOI 10.1007/s40257-017-0280-2
   Witte-Händel E, 2019, J INVEST DERMATOL, V139, P1294, DOI 10.1016/j.jid.2018.11.018
   Wright S, 2021, BRIT J DERMATOL, V185, P74, DOI 10.1111/bjd.19713
   Zouboulis CC, 2015, J EUR ACAD DERMATOL, V29, P619, DOI 10.1111/jdv.12966
   Zouboulis CC, 2019, J AM ACAD DERMATOL, V80, P60, DOI 10.1016/j.jaad.2018.05.040
NR 119
TC 10
Z9 10
U1 1
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9343
EI 1555-7162
J9 AM J MED
JI Am. J. Med.
PD JAN
PY 2023
VL 136
IS 1
BP 42
EP 53
DI 10.1016/j.amjmed.2022.09.025
EA DEC 2022
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 6Z9GN
UT WOS:000898076100019
PM 36252715
OA hybrid
DA 2025-06-11
ER

PT J
AU Bansal, D
   Chahoud, G
   Smith, ES
   Mehta, JL
AF Bansal, Darpan
   Chahoud, Georges
   Smith, Eugene S.
   Mehta, Jawahar L.
TI Prevention of heart failure
SO CURRENT OPINION IN CARDIOLOGY
LA English
DT Review
DE clinical trials; heart failure; prevention
ID CORONARY-ARTERY-DISEASE; CONVERTING-ENZYME-INHIBITOR;
   MYOCARDIAL-INFARCTION; CARDIOVASCULAR EVENTS; METABOLIC SYNDROME;
   LIFETIME RISK; US MEN; DEPRESSION; OUTCOMES; TRIAL
AB Purpose of review
   Chronic heart failure imposes a significant health burden and remains a substantial and increasing problem despite advances in therapy. Hence, prevention of heart failure is a priority.
   Recent findings
   Various risk factors have been identified that contribute to development of heart failure. In this review, we will discuss the various recently reported clinical trials, epidemiological studies, meta-analyses, and subanalyses that have identified these risk factors and have provided evidence regarding the strategies to prevent heart failure.
   Summary
   Heart failure is a costly, disabling, and potentially fatal disease. It is therefore important to incorporate the strategies for prevention of heart failure on the basis of the current available evidence onto routine clinical practice.
C1 Univ Arkansas Med Sci, Div Cardiovasc Med, Dept Internal Med, Little Rock, AR 72205 USA.
   Cent Arkansas Vet Healthcare Syst, Little Rock, AR USA.
C3 University of Arkansas System; University of Arkansas Medical Sciences;
   US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Central Arkansas Veterans Healthcare System
RP Chahoud, G (corresponding author), Univ Arkansas Med Sci, Div Cardiovasc Med, Dept Internal Med, 4301 W Markham,Slot 532, Little Rock, AR 72205 USA.
EM chahoudgeorges@uams.edu
RI Mehta, jl/AAB-8832-2019
CR Alpert MA, 2001, AM J MED SCI, V321, P225, DOI 10.1097/00000441-200104000-00003
   ANDA R, 1993, EPIDEMIOLOGY, V4, P285, DOI 10.1097/00001648-199307000-00003
   [Anonymous], 2003, HEART DIS STROK STAT
   [Anonymous], J AM COLL CARDIOL  S
   Baldasseroni S, 2002, AM HEART J, V143, P398, DOI 10.1067/mhj.2002.121264
   Barefoot JC, 1996, AM J CARDIOL, V78, P613, DOI 10.1016/S0002-9149(96)00380-3
   Barker WH, 2006, CIRCULATION, V113, P799, DOI 10.1161/CIRCULATIONAHA.104.492033
   Berkman LF, 2003, JAMA-J AM MED ASSOC, V289, P3106
   Berl T, 2003, ANN INTERN MED, V138, P542, DOI 10.7326/0003-4819-138-7-200304010-00010
   Bleumink GS, 2004, EUR HEART J, V25, P1614, DOI 10.1016/j.ehj.2004.06.038
   Braunwald E, 2004, NEW ENGL J MED, V351, P2058
   Braunwald E, 1997, NEW ENGL J MED, V337, P1360, DOI 10.1056/NEJM199711063371906
   Brenner BM, 2001, NEW ENGL J MED, V345, P861, DOI 10.1056/NEJMoa011161
   BURT A, 1974, LANCET, V1, P304
   Chen YT, 1999, AM J MED, V106, P605, DOI 10.1016/S0002-9343(99)00126-6
   Cohn JN, 2000, J AM COLL CARDIOL, V35, P569, DOI 10.1016/S0735-1097(99)00630-0
   Denollet J, 2001, CIRCULATION, V104, P2018, DOI 10.1161/hc4201.097940
   Denollet J, 1998, CIRCULATION, V97, P167, DOI 10.1161/01.CIR.97.2.167
   ENGEL GL, 1968, ANN INTERN MED, V69, P293, DOI 10.7326/0003-4819-69-2-293
   Fox KM, 2003, LANCET, V362, P782
   FRASURESMITH N, 1995, CIRCULATION, V91, P999, DOI 10.1161/01.CIR.91.4.999
   Furberg CD, 2002, JAMA-J AM MED ASSOC, V288, P2981
   Gerstein HC, 2000, LANCET, V355, P253
   Glassman AH, 2002, JAMA-J AM MED ASSOC, V288, P701, DOI 10.1001/jama.288.6.701
   Gueyffier F, 1999, LANCET, V353, P793, DOI 10.1016/S0140-6736(98)08127-6
   He J, 2002, ARCH INTERN MED, V162, P1619, DOI 10.1001/archinte.162.14.1619
   He J, 2001, ARCH INTERN MED, V161, P996, DOI 10.1001/archinte.161.7.996
   Hunt Sharon Ann, 2005, J Am Coll Cardiol, V46, pe1, DOI 10.1016/j.jacc.2005.08.022
   Jessup M, 2003, NEW ENGL J MED, V348, P2007, DOI 10.1056/NEJMra021498
   Jiang W, 2001, ARCH INTERN MED, V161, P1849, DOI 10.1001/archinte.161.15.1849
   KANNEL WB, 1994, BRIT HEART J, V72, P3
   Kannell WB, 1999, ARCH INTERN MED, V159, P1197, DOI 10.1001/archinte.159.11.1197
   Kenchaiah S, 2004, MED CLIN N AM, V88, P1273, DOI 10.1016/j.mcna.2004.04.011
   Kenchaiah S, 2002, NEW ENGL J MED, V347, P305, DOI 10.1056/NEJMoa020245
   Kereiakes DJ, 2003, CIRCULATION, V108, P1552, DOI 10.1161/01.CIR.0000093203.00632.2B
   Kjekshus J, 1997, J Card Fail, V3, P249, DOI 10.1016/S1071-9164(97)90022-1
   Kostis JB, 1997, JAMA-J AM MED ASSOC, V278, P212
   Krumholz HM, 2000, AM HEART J, V139, P72, DOI 10.1016/S0002-8703(00)90311-9
   Levy D, 1996, JAMA-J AM MED ASSOC, V275, P1557, DOI 10.1001/jama.275.20.1557
   Lloyd-Jones DM, 2002, CIRCULATION, V106, P3068, DOI 10.1161/01.CIR.0000039105.49749.6F
   *NAT HEART LUNG BL, 1996, DAT FACT SHEET CONG
   Psaty BM, 1997, JAMA-J AM MED ASSOC, V277, P739, DOI 10.1001/jama.277.9.739
   Rich MW, 2001, J GERONTOL A-BIOL, V56, pM88, DOI 10.1093/gerona/56.2.M88
   Richards AM, 2002, J AM COLL CARDIOL, V39, P1182, DOI 10.1016/S0735-1097(02)01737-0
   Vaur L, 2003, DIABETES CARE, V26, P855, DOI 10.2337/diacare.26.3.855
   Wilson PWF, 2003, CIRCULATION, V108, P1422, DOI 10.1161/01.CIR.0000089505.34741.E5
   Yusuf S, 2000, NEW ENGL J MED, V342, P145
NR 47
TC 7
Z9 7
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0268-4705
J9 CURR OPIN CARDIOL
JI Curr. Opin. Cardiol.
PD SEP
PY 2006
VL 21
IS 5
BP 510
EP 516
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 082JZ
UT WOS:000240384200013
PM 16900016
DA 2025-06-11
ER

PT J
AU Chang, YC
   Yu, YH
   Shew, JY
   Lee, WJ
   Hwang, JJ
   Chen, YH
   Chen, YR
   Wei, PC
   Chuang, LM
   Lee, WH
AF Chang, Yi-Cheng
   Yu, Yu-Hsiang
   Shew, Jin-Yuh
   Lee, Wei-Jei
   Hwang, Juey-Jen
   Chen, Yen-Hui
   Chen, Yet-Ran
   Wei, Pei-Chi
   Chuang, Lee-Ming
   Lee, Wen-Hwa
TI Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in
   mice and human
SO EMBO MOLECULAR MEDICINE
LA English
DT Article
DE adipogenesis; C/EBP; N-acetylcysteine; NPGPx; oxidative stress
ID ALPHA-LIPOIC ACID; DIET-INDUCED OBESITY; BODY-MASS INDEX;
   GLUTATHIONE-PEROXIDASE; ADIPOCYTE DIFFERENTIATION; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; CELL-DEATH; PROTECTS; ASSOCIATION
AB Elevated oxidative stress is closely associated with obesity. Emerging evidence shows that instead of being a consequence of obesity, oxidative stress may also contribute to fat formation. Nonselenocysteine-containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) is a conserved oxidative stress sensor/transducer and deficiency of NPGPx causes accumulation of reactive oxygen species (ROS). In this communication, we show that NPGPx was highly expressed in preadipocytes of adipose tissue. Deficiency of NPGPx promoted preadipocytes to differentiate to adipocytes via ROS-dependent dimerization of protein kinase A regulatory subunits and activation of CCAA N-acetylcysteine (NAC). Consistently, NPGPx-deficient mice exhibited markedly increased fat mass and adipocyte hypertrophy, while treatment with NAC ablated these phenotypes. Furthermore, single nucleotide polymorphisms (SNPs) in human NPGPx gene, which correlated with lower NPGPx expression level in adipose tissue, were associated with higher body mass index (BMI) in several independent human populations. These results indicate that NPGPx protects against fat accumulation in mice and human via modulating ROS, and highlight the importance of targeting redox homeostasis in obesity management.
C1 [Chang, Yi-Cheng; Yu, Yu-Hsiang; Shew, Jin-Yuh; Wei, Pei-Chi; Lee, Wen-Hwa] Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan.
   [Chang, Yi-Cheng] Natl Taiwan Univ, Grad Program Translat Med, Taipei 10764, Taiwan.
   [Chang, Yi-Cheng; Hwang, Juey-Jen; Chuang, Lee-Ming] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan.
   [Lee, Wei-Jei] Min Sheng Gen Hosp, Dept Surg, Taoyan, Taiwan.
   [Chen, Yen-Hui] Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan.
   [Chen, Yet-Ran] Acad Sinica, Agr Biotechnol Res Ctr, Taipei 115, Taiwan.
   [Lee, Wen-Hwa] Univ Calif Irvine, Dept Biol Chem, Irvine, CA 92717 USA.
C3 Academia Sinica - Taiwan; National Taiwan University; National Taiwan
   University; National Taiwan University Hospital; Academia Sinica -
   Taiwan; Academia Sinica - Taiwan; University of California System;
   University of California Irvine
RP Lee, WH (corresponding author), Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan.
EM leeming@ntu.edu.tw; whlee@uci.edu
RI Lee, Wen-Hwa/C-2519-2014; Yu, Yu-Hsiang/J-4424-2019; Chen,
   Yi-Ting/I-3161-2013; Chiang, Chieh/C-3815-2015; Chuang,
   Lee-Ming/AAF-3324-2019; Chang, Yi-Cheng/O-1334-2018
OI Wei, Pei-Chi/0000-0002-3309-0511; CHUANG, LEE-MING/0000-0003-0978-2662;
   Chen, Yet-Ran/0000-0002-2409-6655; Chang, Yi-Cheng/0000-0002-8077-5011;
   Yu, Yu-Hsiang/0000-0001-9629-8478; Hwang, Juey-Jen/0000-0001-6437-0455
FU Medical Research Council [G0000934]; Wellcome Trust [068545/Z/02]; NIH
   [R01 HL087679]; National Research Program for Biopharmaceuticals of
   Taiwan; National Science Council of Taiwan [NSC 97-2314-B-002-047-MY3];
   Academia Sinica, Taiwan; MRC [G0000934] Funding Source: UKRI
FX We acknowledge the use of genotype data from the British 1958 Birth
   Cohort DNA collection (funded by the Medical Research Council grant
   G0000934 and the Wellcome Trust grant 068545/Z/02) and the genotype data
   from the Northern Finland Birth Cohort collection (funded by the NIH
   grant R01 HL087679). We thank Dr. Dale R. Nyholt (Queensland Institute
   of Medical Research) for the help of corrections for multiple correlated
   SNPs and Dr. Pi-Hua Liu (Chang-Gung University) for the statistical
   assistance of correction for multiple correlated genetic tests. We thank
   Dr. Eva Y.-H.P. Lee (University of California, Irvine) for critical
   comments of the manuscript. We also thank the Taiwan Mouse Clinic
   (funded by the National Research Program for Biopharmaceuticals of
   Taiwan) for their technical support, the National RNAi Core Facility for
   shRNA plasmid and the Metabolomics Core of Academia Sinica for targeted
   lipidomics study. This work was mainly supported by the Academia Sinica,
   Taiwan to WHL and in part by a grant (NSC 97-2314-B-002-047-MY3) from
   the National Science Council of Taiwan to LMC The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript. YHY was supported by a postdoc fellowship
   and YCC by a fellowship for Translational Medicine Graduate Program from
   the Academia Sinica, Taiwan.
CR Anso E, 2011, CELL METAB, V14, P537
   Barrett JC, 2005, BIOINFORMATICS, V21, P263, DOI 10.1093/bioinformatics/bth457
   Brennan JP, 2004, J BIOL CHEM, V279, P41352, DOI 10.1074/jbc.M403827200
   Carbonelli MG, 2010, CURR PHARM DESIGN, V16, P840, DOI 10.2174/138161210790883589
   Chabory E, 2009, J CLIN INVEST, V119, P2074, DOI 10.1172/JCI38940
   CHU FF, 1993, J BIOL CHEM, V268, P2571
   D'Autréaux B, 2007, NAT REV MOL CELL BIO, V8, P813, DOI 10.1038/nrm2256
   Diano S, 2011, NAT MED, V17, P1121, DOI 10.1038/nm.2421
   Festa A, 2001, INT J OBESITY, V25, P1407, DOI 10.1038/sj.ijo.0801792
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Han YH, 2009, ONCOL REP, V21, P253, DOI 10.3892/or_00000216
   Heard KJ, 2008, NEW ENGL J MED, V359, P285, DOI 10.1056/NEJMct0708278
   Ho YS, 1997, J BIOL CHEM, V272, P16644, DOI 10.1074/jbc.272.26.16644
   Huh JY, 2012, ANTIOXID REDOX SIGN, V16, P229, DOI [10.1089/ars.2011.3952, 10.1089/ars.2010.3766]
   Imai H, 2009, J BIOL CHEM, V284, P32522, DOI 10.1074/jbc.M109.016139
   Jones JR, 2005, P NATL ACAD SCI USA, V102, P6207, DOI 10.1073/pnas.0306743102
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Kim E, 2008, J CLIN PSYCHOPHARM, V28, P138, DOI 10.1097/JCP.0b013e31816777f7
   Kim J, 2007, P NATL ACAD SCI USA, V104, P1800, DOI 10.1073/pnas.0611137104
   Koh EH, 2011, AM J MED, V124, DOI 10.1016/j.amjmed.2010.08.005
   Lane MD, 2012, ANN REV BIOCH, V81, P715
   Lin JW, 2009, DIABETES CARE, V32, P2294, DOI 10.2337/dc09-0694
   Liu N, 2002, J NEUROVIROL, V8, P318, DOI 10.1080/13550280290100699
   Marenzi G, 2006, NEW ENGL J MED, V354, P2773, DOI 10.1056/NEJMoa054209
   Nguyen VD, 2011, J MOL BIOL, V406, P503, DOI 10.1016/j.jmb.2010.12.039
   Nyholt DR, 2004, AM J HUM GENET, V74, P765, DOI 10.1086/383251
   O'Rahilly S, 2009, NATURE, V462, P307, DOI 10.1038/nature08532
   Otto, 2003, P NATL ACAD SCI US, V100, P850
   PACKER L, 1995, FREE RADICAL BIO MED, V19, P227, DOI 10.1016/0891-5849(95)00017-R
   Peng DF, 2012, GUT, V61, P1250, DOI 10.1136/gutjnl-2011-301078
   Pergola PE, 2011, NEW ENGL J MED, V365, P327, DOI 10.1056/NEJMoa1105351
   Platte P, 2003, AM J MED GENET C, V121C, P71, DOI 10.1002/ajmg.c.20005
   Rosen ED, 2006, NAT REV MOL CELL BIO, V7, P885, DOI 10.1038/nrm2066
   Sabatti C, 2009, NAT GENET, V41, P35, DOI 10.1038/ng.271
   Seda O, 2005, PHYSIOL GENOMICS, V21, P243, DOI 10.1152/physiolgenomics.00230.2004
   So HC, 2011, BEHAV GENET, V41, P768, DOI 10.1007/s10519-011-9450-9
   Speliotes EK, 2010, NAT GENET, V42, P937, DOI 10.1038/ng.686
   Urakawa H, 2003, J CLIN ENDOCR METAB, V88, P4673, DOI 10.1210/jc.2003-030202
   Utomo A, 2004, J BIOL CHEM, V279, P43522, DOI 10.1074/jbc.M407141200
   Vanin S, 2008, ANTIOXID REDOX SIGNA, V10, P1501
   Weerapana E, 2010, NATURE, V468, P790, DOI 10.1038/nature09472
   Wei PC, 2012, MOL CELL, V48, P747, DOI 10.1016/j.molcel.2012.10.007
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   YEH WC, 1995, GENE DEV, V9, P168, DOI 10.1101/gad.9.2.168
   YOSHIMURA S, 1991, J BIOCHEM-TOKYO, V109, P918, DOI 10.1093/oxfordjournals.jbchem.a123480
   ZIEGLER DM, 1985, ANNU REV BIOCHEM, V54, P305, DOI 10.1146/annurev.biochem.54.1.305
NR 46
TC 60
Z9 63
U1 0
U2 19
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1757-4676
EI 1757-4684
J9 EMBO MOL MED
JI EMBO Mol. Med.
PD AUG
PY 2013
VL 5
IS 8
BP 1165
EP 1179
DI 10.1002/emmm.201302679
PG 15
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 195QE
UT WOS:000322717900006
PM 23828861
OA Green Published
DA 2025-06-11
ER

PT J
AU Wouters, HJCM
   van Loon, HCM
   van der Klauw, MM
   Elderson, MF
   Slagter, SN
   Kobold, AM
   Kema, IP
   Links, TP
   van Vliet-Ostaptchouk, JV
   Wolffenbuttel, BHR
AF Wouters, Hanneke J. C. M.
   van Loon, Hannah C. M.
   van der Klauw, Melanie M.
   Elderson, Martin F.
   Slagter, Sandra N.
   Kobold, Anneke Muller
   Kema, Ido P.
   Links, Thera P.
   van Vliet-Ostaptchouk, Jana V.
   Wolffenbuttel, Bruce H. R.
TI No Effect of the Thr92Ala Polymorphism of Deiodinase-2 on Thyroid
   Hormone Parameters, Health-Related Quality of Life, and Cognitive
   Functioning in a Large Population-Based Cohort Study
SO THYROID
LA English
DT Article
DE TSH; free T4; general population; quality of life; deiodinase-2;
   polymorphism; executive functioning
ID TYPE-2 DEIODINASE; L-THYROXINE; COMMON VARIATION; GENE; ASSOCIATION;
   COMBINATION; THERAPY; TSH; HYPOTHYROIDISM; LEVOTHYROXINE
AB Introduction: The presence of the Thr92Ala polymorphism of deiodinase-2 (D2) has been thought to have several effects. It may influence its enzymatic function, is associated with increased expression of genes involved in oxidative stress in brain tissue, and may predict favorable response to combination levothyroxine (LT4) plus triiodothyronine (T3) therapy. It was hypothesized that homozygous carriers of the D2-92Ala allele have different thyroid hormone parameters, and reduced health-related quality of life (HRQoL) and cognitive functioning.
   Methods: In 12,625 participants from the LifeLines cohort study with genome-wide genetic data available, the effects of the Thr92Ala polymorphism (rs225014) were evaluated in the general population and in 364 people treated with thyroid hormone replacement therapy, the latter mainly because of primary hypothyroidism. In addition to evaluating anthropometric data, medication use, and existence of metabolic syndrome, HRQoL was assessed with the RAND 36-Item Health Survey, and the Ruff Figural Fluency Test was used as a sensitive test for executive functioning. Data on thyrotropin, free thyroxine (fT4), and free T3 (fT3) levels were available in a subset of 4479 participants.
   Results: The mean age (-standard deviation) was 53 +/- 12 years and the body mass index was 27.0 +/- 4.5 kg/m(2) in the LT4 users compared with 48 +/- 11 years and 26.2 +/- 4.1 kg/m(2) in participants from the general population. The Ala/Ala genotype of the D2-Thr92Ala polymorphism was present in 11.3% of LT4 users and in 10.7% of the general population. In total, 3742/4479 subjects with thyroid hormone data available had normal TSH (0.4-4.0 mIU/L), and 88% of LT4 users were females. LT4 users had higher fT4, lower fT3, and a lower fT3/fT4 ratio, and female patients had lower scores on the HRQoL domains of physical functioning, vitality, mental health, social functioning, bodily pain, and general health compared with those not using LT4 (p < 0.005). Executive functioning scores, as part of cognitive functioning, were comparable between female LT4 users and the general population. In both groups, the D2-Thr92Ala polymorphism was not associated with differences in TSH, fT4, fT3, the fT3/fT4 ratio, presence of metabolic syndrome or other comorbidities, use of medication, HRQoL, and cognitive functioning.
   Conclusion: The Thr92Ala polymorphism of D2 was not associated with thyroid parameters, HRQoL, and cognitive functioning in the general population and in participants on thyroid hormone replacement therapy.
C1 [Wouters, Hanneke J. C. M.; van Loon, Hannah C. M.; van der Klauw, Melanie M.; Elderson, Martin F.; Slagter, Sandra N.; Links, Thera P.; van Vliet-Ostaptchouk, Jana V.; Wolffenbuttel, Bruce H. R.] Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol & Metab, Groningen, Netherlands.
   [Kobold, Anneke Muller; Kema, Ido P.] Univ Groningen, Univ Med Ctr Groningen, Dept Lab Med, Groningen, Netherlands.
C3 University of Groningen; University of Groningen
RP Wolffenbuttel, BHR (corresponding author), Univ Med Ctr Groningen, Dept Endocrinol, HPC AA31,POB 30001, NL-9700 RB Groningen, Netherlands.
EM bwo@umcg.nl
RI Muller Kobold, Anna/HHC-2189-2022; van der Klauw, Melanie/A-2138-2014
OI Wolffenbuttel, Bruce H.R./0000-0001-9262-6921; Muller Kobold,
   Anneke/0000-0003-3457-4179; van Vliet-Ostaptchouk,
   Jana/0000-0002-7943-3153; van der Klauw, Melanie/0000-0001-7178-009X
FU Dutch Government; Netherlands Organization of Scientific Research NOW
   [175.010.2007.006]; Northern Netherlands Collaboration of Provinces
   (SNN); European fund for regional development; Target project;
   University of Groningen; University Medical Center Groningen,
   Netherlands; National Consortium for Healthy Ageing; European Union
   [261433]; Dutch Ministry of Economic Affairs; Pieken in de Delta;
   Province of Groningen; Province of Drenthe; BBMRI-NL
FX LifeLines has been funded by a number of public sources, notably the
   Dutch Government, The Netherlands Organization of Scientific Research
   NOW (grant 175.010.2007.006), the Northern Netherlands Collaboration of
   Provinces (SNN), the European fund for regional development, Dutch
   Ministry of Economic Affairs, Pieken in de Delta, Provinces of Groningen
   and Drenthe, the Target project, BBMRI-NL, the University of Groningen,
   and the University Medical Center Groningen, Netherlands. This work was
   supported by the National Consortium for Healthy Ageing, and funds from
   the European Union's Seventh Framework program (FP7/2007-2013) through
   the BioSHaRE-EU (Biobank Standardisation and Harmonisation for Research
   Excellence in the European Union) project, grant agreement 261433.
   LifeLines (BRIF4568) is engaged in a Bioresource research impact factor
   (BRIF) policy pilot study, details of which can be found at
   www.bioshare.eu/content/bioresource-impact-factor.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Alevizaki M, 2005, WIEN KLIN WOCHENSCHR, V117, P636, DOI 10.1007/s00508-005-0421-0
   Appelhof BC, 2005, J CLIN ENDOCR METAB, V90, P6296, DOI 10.1210/jc.2005-0451
   Bianco AC, 2002, ENDOCR REV, V23, P38, DOI 10.1210/er.23.1.38
   Boelen A, 2005, ENDOCRINOLOGY, V146, P5128, DOI 10.1210/en.2005-0608
   Brummelman P, 2011, CLIN ENDOCRINOL, V74, P481, DOI 10.1111/j.1365-2265.2010.03947.x
   Bunevicius R, 1999, NEW ENGL J MED, V340, P424, DOI 10.1056/NEJM199902113400603
   Butler PW, 2010, THYROID, V20, P1407, DOI 10.1089/thy.2010.0244
   Callebaut I, 2003, J BIOL CHEM, V278, P36887, DOI 10.1074/jbc.M305725200
   Canaris GJ, 2000, ARCH INTERN MED, V160, P526, DOI 10.1001/archinte.160.4.526
   Celi FS, 2000, EUR J ENDOCRINOL, V143, P267, DOI 10.1530/eje.0.1430267
   Davis J D, 2007, Minerva Endocrinol, V32, P49
   de Jong FJ, 2007, J CLIN ENDOCR METAB, V92, P636, DOI 10.1210/jc.2006-1331
   Escobar-Morreale HF, 2015, BEST PRACT RES CL EN, V29, P57, DOI 10.1016/j.beem.2014.10.004
   Madariaga AG, 2014, J CLIN ENDOCR METAB, V99, P923, DOI 10.1210/jc.2013-2409
   Grarup N, 2007, J CLIN ENDOCR METAB, V92, P363, DOI 10.1210/jc.2006-1958
   Gullo D, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0022552
   Heemstra KA, 2009, CLIN ENDOCRINOL, V71, P279, DOI 10.1111/j.1365-2265.2008.03474.x
   Izaks GJ, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017045
   Jansen H, 2013, J INTERN MED, V273, P283, DOI 10.1111/joim.12010
   Jonklaas J, 2014, THYROID, V24, P1670, DOI 10.1089/thy.2014.0028
   Klaver EI, 2013, THYROID, V23, P1066, DOI 10.1089/thy.2013.0017
   McAninch EA, 2015, LANCET DIABETES ENDO, V3, P756, DOI 10.1016/S2213-8587(15)00325-3
   McAninch EA, 2015, J CLIN ENDOCR METAB, V100, P920, DOI 10.1210/jc.2014-4092
   Panicker V, 2008, J CLIN ENDOCR METAB, V93, P3075, DOI 10.1210/jc.2008-0397
   Panicker V, 2009, J CLIN ENDOCR METAB, V94, P1623, DOI 10.1210/jc.2008-1301
   Peeters RP, 2003, J CLIN ENDOCR METAB, V88, P2880, DOI 10.1210/jc.2002-021592
   Peeters RP, 2005, AM J PHYSIOL-ENDOC M, V289, pE75, DOI 10.1152/ajpendo.00571.2004
   PILO A, 1990, AM J PHYSIOL, V258, pE715, DOI 10.1152/ajpendo.1990.258.4.E715
   Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795
   RUFF RM, 1987, DEV NEUROPSYCHOL, V3, P37, DOI 10.1080/87565648709540362
   Samuels MH, 2007, THYROID, V17, P249, DOI 10.1089/thy.2006.0252
   Samuels MH, 2014, J CLIN ENDOCR METAB, V99, P843, DOI 10.1210/jc.2013-3686
   Santoro AB, 2014, BRIT J CLIN PHARMACO, V78, P1067, DOI 10.1111/bcp.12437
   Saravanan P, 2002, CLIN ENDOCRINOL, V57, P577, DOI 10.1046/j.1365-2265.2002.01654.x
   Scholtens S, 2015, INT J EPIDEMIOL, V44, P1172, DOI 10.1093/ije/dyu229
   Schubert CC, 2006, J AM GERIATR SOC, V54, P104, DOI 10.1111/j.1532-5415.2005.00543.x
   Slagter SN, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0140599
   Taylor PN, 2013, J CLIN ENDOCR METAB, V98, P3562, DOI 10.1210/jc.2013-1315
   Torlontano M, 2008, J CLIN ENDOCR METAB, V93, P910, DOI 10.1210/jc.2007-1067
   van der Zee KI, 1996, INT J BEHAV MED, V3, P104, DOI 10.1207/s15327558ijbm0302_2
   van Eersel MEA, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0121411
   Verloop H, 2014, EUR J ENDOCRINOL, V171, pR123, DOI 10.1530/EJE-14-0302
   Wartofsky L, 2013, CURR OPIN ENDOCRINOL, V20, P460, DOI 10.1097/01.med.0000432611.03732.49
   Wekking EM, 2005, EUR J ENDOCRINOL, V153, P747, DOI 10.1530/eje.1.02025
   Wiersinga WM, 2012, EUR THYROID J, V1, P55, DOI 10.1159/000339444
NR 46
TC 75
Z9 78
U1 0
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1050-7256
EI 1557-9077
J9 THYROID
JI Thyroid
PD FEB
PY 2017
VL 27
IS 2
BP 147
EP 155
DI 10.1089/thy.2016.0199
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA EK6RK
UT WOS:000394051600004
PM 27786042
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Bermejo-Millo, JC
   Guimaraes, MRM
   de Luxán-Delgado, B
   Potes, Y
   Pérez-Martínez, Z
   Díaz-Luis, A
   Caballero, B
   Solano, JJ
   Vega-Naredo, I
   Coto-Montes, A
AF Carlos Bermejo-Millo, Juan
   Moreira Guimaraes, Marcela Rodrigues
   de Luxan-Delgado, Beatriz
   Potes, Yaiza
   Perez-Martinez, Zulema
   Diaz-Luis, Andrea
   Caballero, Beatriz
   Jose Solano, Juan
   Vega-Naredo, Ignacio
   Coto-Montes, Ana
TI High-Fructose Consumption Impairs the Redox System and Protein Quality
   Control in the Brain of Syrian Hamsters: Therapeutic Effects of
   Melatonin
SO MOLECULAR NEUROBIOLOGY
LA English
DT Article
DE High-fructose; Brain; ER stress; Autophagy; Neurodegeneration; Melatonin
ID GLYCATION END-PRODUCTS; ENDOPLASMIC-RETICULUM STRESS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   GLUCOSE-TOLERANCE; LIPID-METABOLISM; BLOOD-LIPIDS; RISK-FACTOR;
   URIC-ACID
AB Although numerous studies have demonstrated the harmful effect of excessive fructose consumption at the systemic level, there is little information on its effects in the central nervous system. The purpose of the present work was to study the cellular alterations related to oxidative stress and protein quality control systems induced by a high-fructose diet in the brain of Syrian hamsters and their possible attenuation by exogenous melatonin. High-fructose intake induced type II diabetes together with oxidative damage, led to alterations of the unfolded protein response by activating the eIF2 alpha branch, and impaired the macroautophagic machinery in the brain, favoring the accumulation of aggregates labeled for selective degradation and neurodegeneration markers such as beta-amyloid (1-42), tau-p-S199, and tau-p-S404. Melatonin attenuated the manifestation of type II diabetes and reduced oxidative stress, deactivated eIF2 alpha, and decreased tau-p-S404 levels in the brain of animals fed a high-fructose diet.
C1 [Carlos Bermejo-Millo, Juan; Moreira Guimaraes, Marcela Rodrigues; de Luxan-Delgado, Beatriz; Potes, Yaiza; Perez-Martinez, Zulema; Diaz-Luis, Andrea; Caballero, Beatriz; Vega-Naredo, Ignacio; Coto-Montes, Ana] Univ Oviedo, Fac Med, Dept Morphol & Cell Biol, E-33006 Oviedo, Spain.
   [Carlos Bermejo-Millo, Juan; Potes, Yaiza; Perez-Martinez, Zulema; Diaz-Luis, Andrea; Caballero, Beatriz; Jose Solano, Juan; Vega-Naredo, Ignacio; Coto-Montes, Ana] IISPA, Oviedo 33011, Spain.
   [Perez-Martinez, Zulema] Univ Cent Hosp Asturias, Serv Microbiol, Oviedo 33011, Spain.
C3 University of Oviedo; Instituto de Investigacion Sanitaria del
   Principado de Asturias (ISPA)
RP Vega-Naredo, I (corresponding author), Univ Oviedo, Fac Med, Dept Morphol & Cell Biol, E-33006 Oviedo, Spain.; Vega-Naredo, I (corresponding author), IISPA, Oviedo 33011, Spain.
EM naredo@gmail.com
RI Vega-Naredo, Ignacio/A-4245-2009; Luxán-Delgado, Beatriz/AAC-8452-2020;
   Potes, Yaiza/AAU-2188-2021; Caballero García, Beatriz/AAC-2636-2020;
   coto-montes, ana/D-2544-2016
OI Vega-Naredo, Ignacio/0000-0003-1993-6725; Luxan-Delgado,
   Beatriz/0000-0003-4507-716X; Caballero Garcia,
   Beatriz/0000-0003-0242-9620; Potes, Yaiza/0000-0002-4687-6230
FU Instituto de Salud Carlos III (Spanish Ministry of Economy and
   Competitiveness) [RD12/0043/0030, RD12/0043/0017, PI13/02741,
   PI17/02009, FI14/00405]; Government of the Principality of Asturias
   [GRUPIN14-071]; European Regional Development Fund; AINDACE (Ayuda a la
   Investigacion del Dano Cerebral) foundation (Spain); PUEDES Program
   (European Commission) [2013-2586/001-001-EMA2]
FX This work was supported by the Instituto de Salud Carlos III (Spanish
   Ministry of Economy and Competitiveness) under grants RD12/0043/0030,
   RD12/0043/0017, PI13/02741 and PI17/02009; and the Government of the
   Principality of Asturias under grant GRUPIN14-071, all of them
   co-financed by the European Regional Development Fund. J.C.B.M.
   acknowledges his MSc thesis award from AINDACE (Ayuda a la Investigacion
   del Dano Cerebral) foundation (Spain). M.R.M.G acknowledges her
   postdoctoral fellowship (2013-2586/001-001-EMA2) from the PUEDES Program
   (European Commission). Y.P. acknowledges her predoctoral fellow
   (FI14/00405) from the Instituto de Salud Carlos III (Spanish Ministry of
   Economy and Competitiveness).
CR Agrawal R, 2012, J PHYSIOL-LONDON, V590, P2485, DOI 10.1113/jphysiol.2012.230078
   Äijälä M, 2013, GENES NUTR, V8, P623, DOI 10.1007/s12263-013-0357-3
   Andersen JK, 2004, NAT MED, V10, pS18, DOI 10.1038/nrn1434
   Aragno M, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040385
   Ariyasu D, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18020382
   Arnao MB, 2001, FOOD CHEM, V73, P239, DOI 10.1016/S0308-8146(00)00324-1
   Baena M, 2015, BBA-MOL CELL BIOL L, V1851, P107, DOI 10.1016/j.bbalip.2014.11.003
   Bhathena J, 2011, DIABETES METAB SYNDR, V4, P195, DOI 10.2147/DMSO.S18435
   Bidwell AJ, 2017, NUTRIENTS, V9, DOI 10.3390/nu9060549
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   BRAVO E, 1994, COMP BIOCHEM PHYS B, V107, P347, DOI 10.1016/0305-0491(94)90058-2
   Cardinali DP, 2013, INT J MOL SCI, V14, P2502, DOI 10.3390/ijms14022502
   Cigliano L, 2018, MOL NEUROBIOL, V55, P2869, DOI 10.1007/s12035-017-0518-2
   Clark IA, 2013, BIOCHEM PHARMACOL, V86, P862, DOI 10.1016/j.bcp.2013.07.030
   De Felice FG, 2014, ALZHEIMERS DEMENT, V10, pS26, DOI 10.1016/j.jalz.2013.12.004
   de Gonzalo-Calvo D, 2010, FREE RADICAL BIO MED, V49, P733, DOI 10.1016/j.freeradbiomed.2010.05.019
   de la Monte SM, 2014, BIOCHEM PHARMACOL, V88, P548, DOI 10.1016/j.bcp.2013.12.012
   Dillard A, 2010, NUTR METAB, V7, DOI 10.1186/1743-7075-7-89
   Dolan LC, 2010, CRIT REV FOOD SCI, V50, P889, DOI 10.1080/10408398.2010.512990
   Eckel RH, 2015, CURR BIOL, V25, P3004, DOI 10.1016/j.cub.2015.10.011
   Egawa N, 2011, J BIOL CHEM, V286, P7947, DOI 10.1074/jbc.M110.156430
   ESTERBAUER H, 1990, METHOD ENZYMOL, V186, P407
   Evans DB, 2000, J BIOL CHEM, V275, P24977, DOI 10.1074/jbc.M000808200
   Ferreira ST, 2014, ALZHEIMERS DEMENT, V10, pS76, DOI 10.1016/j.jalz.2013.12.010
   Galano A, 2013, J PINEAL RES, V54, P245, DOI 10.1111/jpi.12010
   García Teresa, 2004, Gac. Méd. Méx, V140, P329
   Gérard-Monnier D, 1998, CHEM RES TOXICOL, V11, P1176, DOI 10.1021/tx9701790
   Hardeland R., 2017, PINEAL GLAND RES ADV, P163
   Hashida K, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047950
   Jagua Gualdrón Andrés, 2007, rev.fac.med., V55, P66
   Jin BK, 1998, NEUROSCI LETT, V245, P61, DOI 10.1016/S0304-3940(98)00170-0
   Johnson RJ, 2009, ENDOCR REV, V30, P96, DOI 10.1210/er.2008-0033
   Kaneko YK, 2015, BIOL PHARM BULL, V38, P669, DOI 10.1248/bpb.b15-00060
   KasimKarakas SE, 1996, J LAB CLIN MED, V128, P208, DOI 10.1016/S0022-2143(96)90013-X
   Kitagawa A, 2012, J PINEAL RES, V52, P403, DOI 10.1111/j.1600-079X.2011.00955.x
   Lin L, 2013, INT J MOL SCI, V14, P14575, DOI 10.3390/ijms140714575
   LIU GL, 1991, COMP BIOCHEM PHYS A, V99, P223, DOI 10.1016/0300-9629(91)90263-C
   Lopes A, 2014, MOL NEUROBIOL, V50, P1124, DOI 10.1007/s12035-014-8676-y
   Lowette Katrien, 2015, Front Nutr, V2, P5, DOI 10.3389/fnut.2015.00005
   LUBINSKY S, 1979, GENETICS, V91, P723
   Lyssenko V, 2009, NAT GENET, V41, P82, DOI 10.1038/ng.288
   Manzano-León Natalia, 2006, Gac. Méd. Méx, V142, P229
   MARTIN JP, 1987, ARCH BIOCHEM BIOPHYS, V255, P329, DOI 10.1016/0003-9861(87)90400-0
   McMullan CJ, 2013, AM J EPIDEMIOL, V178, P231, DOI 10.1093/aje/kws470
   Mico CC, 2010, MONOGRAFIA, P283
   Nagai Y, 2009, CELL METAB, V9, P252, DOI 10.1016/j.cmet.2009.01.011
   Naples M, 2012, AM J PHYSIOL-GASTR L, V302, pG1043, DOI 10.1152/ajpgi.00250.2011
   Otoda T, 2013, DIABETES, V62, P811, DOI 10.2337/db11-1652
   Ottum MS, 2015, J CLIN BIOCHEM NUTR, V57, P1, DOI 10.3164/jcbn.15-3
   PARK J, 2015, EVID-BASED COMPL ALT, V1, DOI DOI 10.1155/2015/385976
   Pereira RM, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040405
   Putakala M, 2017, APPL BIOCHEM BIOTECH, V183, P744, DOI 10.1007/s12010-017-2461-0
   Rankin CA, 2008, NEUROBIOL DIS, V31, P368, DOI 10.1016/j.nbd.2008.05.011
   Rasheed Z, 2012, BBA-MOL CELL RES, V1823, P2179, DOI 10.1016/j.bbamcr.2012.08.021
   REISER S, 1989, AM J CLIN NUTR, V49, P832, DOI 10.1093/ajcn/49.5.832
   Reiter RJ, 2016, J PINEAL RES, V61, P253, DOI 10.1111/jpi.12360
   Ren LP, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030816
   Rubio-Sastre P, 2014, SLEEP, V37, P1715, DOI 10.5665/sleep.4088
   Russell JC, 2006, CARDIOVASC PATHOL, V15, P318, DOI 10.1016/j.carpath.2006.09.001
   Seneff S, 2011, EUR J INTERN MED, V22, P134, DOI 10.1016/j.ejim.2010.12.017
   Stephan BCM, 2010, J GERONTOL A-BIOL, V65, P809, DOI 10.1093/gerona/glq079
   Taghibiglou C, 2000, J BIOL CHEM, V275, P8416, DOI 10.1074/jbc.275.12.8416
   Tsakiri EN, 2013, FREE RADICAL BIO MED, V65, P1155, DOI 10.1016/j.freeradbiomed.2013.08.186
   Tuomi T, 2016, CELL METAB, V23, P1067, DOI 10.1016/j.cmet.2016.04.009
   Wang YN, 2016, SCI REP-UK, V6, DOI 10.1038/srep28014
   Whitcomb EA, 2015, MOL ASPECTS MED, V46, P14, DOI 10.1016/j.mam.2015.08.005
   WHO, 2003, WHO TECH REP SER, V916, P1
   Wu AG, 2004, EUR J NEUROSCI, V19, P1699, DOI 10.1111/j.1460-9568.2004.03246.x
   Zha BS, 2012, BIOCHEM RES INT, V2012, DOI 10.1155/2012/312943
NR 69
TC 13
Z9 13
U1 0
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0893-7648
EI 1559-1182
J9 MOL NEUROBIOL
JI Mol. Neurobiol.
PD OCT
PY 2018
VL 55
IS 10
BP 7973
EP 7986
DI 10.1007/s12035-018-0967-2
PG 14
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GT1FX
UT WOS:000444207800026
PM 29492847
DA 2025-06-11
ER

PT J
AU Fernández-Iglesias, A
   Pajuelo, D
   Quesada, H
   Díaz, S
   Bladé, C
   Arola, L
   Salvadó, MJ
   Mulero, M
AF Fernandez-Iglesias, Anabel
   Pajuelo, David
   Quesada, Helena
   Diaz, Sabina
   Blade, Cinta
   Arola, Lluis
   Josepa Salvado, Maria
   Mulero, Miquel
TI Grape seed proanthocyanidin extract improves the hepatic glutathione
   metabolism in obese Zucker rats
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Liver; Glutathione; Oxidative Stress; Proanthocyanidins; Zucker fatty
   rats
ID OXIDATIVE STRESS; PROCYANIDIN EXTRACT; MITOCHONDRIAL-FUNCTION;
   ANTIOXIDANT CAPACITY; ADIPOSE-TISSUE; FA/FA RATS; IN-VITRO; LEPTIN;
   ACID; INFLAMMATION
AB ScopeIncreased oxidative stress may play an important role in metabolic syndrome and related manifestations, including obesity, atherosclerosis, hypertension, and insulin resistance. Its relation to obesity is due to increased reactive oxygen species and/or decreased glutathione (GSH) antioxidant metabolism. Consequently, the activation of glutathione metabolism appears to be a central defense response to prevent oxidative stress. In this sense, dietary supplements with natural antioxidant molecules, including proanthocyanidins, may present a useful strategy of controlling and reducing complications of obesity, including hepatic steatosis.
   Materials and resultsWe assessed the grape seed proanthocyanidin extract (GSPE) effect on oxidative alterations related to genetically obese rats (Zucker rats) and, more specifically, to hepatic GSH metabolism. We demonstrate that the administration of GSPE reduced the oxidized glutathione accumulation increasing the total GSH/oxidized glutathione hepatic ratio and consequently decreasing the activation of antioxidant enzymes, including glutathione peroxidase, glutathione reductase, and glutathione S-transferase, and increasing the total antioxidant capacity of the cell.
   ConclusionIn Zucker rats, the obesity-induced oxidative stress related to liver glutathione alteration was mitigated by GSPE administration.
C1 [Fernandez-Iglesias, Anabel; Pajuelo, David; Quesada, Helena; Diaz, Sabina; Blade, Cinta; Arola, Lluis; Josepa Salvado, Maria; Mulero, Miquel] Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Grp Nutrigen, E-43007 Tarragona, Spain.
C3 Universitat Rovira i Virgili
RP Mulero, M (corresponding author), Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Grp Nutrigen, Campus Sescelades,Marcel Li Domingo S-N, E-43007 Tarragona, Spain.
EM miquel.mulero@urv.cat
RI Fernández-Iglesias, Anabel/AAD-6811-2020; Vázquez, Helena/AAC-2695-2021;
   Pajuelo Reguera, David/G-3814-2014; Arola, Lluis/C-6074-2011; Mulero,
   Miquel/L-4672-2014; Fernandez-Iglesias, Anabel/K-2285-2015; SALVADO,
   JOSEPA/B-6062-2015
OI Pajuelo Reguera, David/0000-0002-7715-9402; Blade,
   Cinta/0000-0003-2838-2402; Arola, Lluis/0000-0003-2767-1974; Mulero,
   Miquel/0000-0003-2545-2065; Fernandez-Iglesias,
   Anabel/0000-0003-2364-6675; SALVADO, JOSEPA/0000-0003-3883-3326
FU FPI from the "Ministerio de Economia y Competitividad (MINECO)" for
   Ph.D. students; MINECO of the Spanish Government [AGL2008-00387/ALI]
FX The present study was supported by a grant FPI from the "Ministerio de
   Economia y Competitividad (MINECO)" for Ph.D. students and a grant from
   the MINECO AGL2008-00387/ALI of the Spanish Government.
CR ALI SF, 1992, NEUROTOXICOLOGY, V13, P637
   Anderson M E, 1997, Adv Pharmacol, V38, P65
   Ardévol A, 2013, FOOD CHEM, V141, P160, DOI 10.1016/j.foodchem.2013.02.104
   Belobrajdic DP, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-27
   Bladé C, 2010, MOL NUTR FOOD RES, V54, P37, DOI 10.1002/mnfr.200900476
   CARLBERG I, 1985, METHOD ENZYMOL, V113, P484
   Castrillejo VM, 2011, NUTRITION, V27, P1172, DOI 10.1016/j.nut.2010.12.010
   Cedó L, 2012, FOOD CHEM, V135, P1948, DOI 10.1016/j.foodchem.2012.06.042
   Chrysohoou C, 2007, NUTR METAB CARDIOVAS, V17, P590, DOI 10.1016/j.numecd.2006.05.007
   Estruch R, 2011, NUTR METAB CARDIOVAS, V21, P46, DOI 10.1016/j.numecd.2009.07.006
   Fang YZ, 2002, NUTRITION, V18, P872, DOI 10.1016/S0899-9007(02)00916-4
   FLOHE L, 1984, METHOD ENZYMOL, V105, P114
   Gilbert M, 2003, DIABETES, V52, P277, DOI 10.2337/diabetes.52.2.277
   Gómez-Zorita S, 2012, BRIT J NUTR, V107, P202, DOI 10.1017/S0007114511002753
   Gonthier MP, 2003, FREE RADICAL BIO MED, V35, P837, DOI 10.1016/S0891-5849(03)00394-0
   GRIFFITH OW, 1980, ANAL BIOCHEM, V106, P207, DOI 10.1016/0003-2697(80)90139-6
   HABIG WH, 1974, J BIOL CHEM, V249, P7130
   Hill MF, 2008, CURR CARDIOL REV, V4, P259, DOI 10.2174/157340308786349453
   Huang DJ, 2002, J AGR FOOD CHEM, V50, P4437, DOI 10.1021/jf0201529
   Covas MI, 2010, ATHEROSCLEROSIS, V208, P297, DOI 10.1016/j.atherosclerosis.2009.06.031
   Jalil AMM, 2008, J AGR FOOD CHEM, V56, P7877, DOI 10.1021/jf8015915
   Justo ML, 2013, EUR J NUTR, V52, P789, DOI 10.1007/s00394-012-0385-6
   Kesh SB, 2013, LIFE SCI, V92, P938, DOI 10.1016/j.lfs.2013.03.015
   Kusirisin W, 2009, MED CHEM, V5, P583, DOI 10.2174/157340609790170443
   Leite AV, 2011, J AGR FOOD CHEM, V59, P2277, DOI 10.1021/jf103181x
   Lockman KA, 2012, LIVER INT, V32, P1079, DOI 10.1111/j.1478-3231.2012.02775.x
   Lolmède K, 2011, DIABETES METAB, V37, P283, DOI 10.1016/j.diabet.2011.03.002
   Justo ML, 2013, J NUTR BIOCHEM, V24, P1453, DOI 10.1016/j.jnutbio.2012.12.004
   MICHIELS C, 1994, FREE RADICAL BIO MED, V17, P235, DOI 10.1016/0891-5849(94)90079-5
   Morán-Ramos S, 2012, J NUTR, V142, P1956, DOI 10.3945/jn.112.165563
   Moskaug JO, 2005, AM J CLIN NUTR, V81, p277S, DOI 10.1093/ajcn/81.1.277S
   Myhrstad MCW, 2002, FREE RADICAL BIO MED, V32, P386, DOI 10.1016/S0891-5849(01)00812-7
   Noeman SA, 2011, DIABETOL METAB SYNDR, V3, DOI 10.1186/1758-5996-3-17
   Pajuelo D, 2011, J AGR FOOD CHEM, V59, P8491, DOI 10.1021/jf201775v
   Pallares V., 2013, FREE RADIC BIOL MED
   Pallarès V, 2013, FOOD RES INT, V53, P319, DOI 10.1016/j.foodres.2013.05.006
   Pedret A, 2012, MOL NUTR FOOD RES, V56, P1025, DOI 10.1002/mnfr.201100676
   Prior RL, 2003, J AGR FOOD CHEM, V51, P3273, DOI 10.1021/jf0262256
   Puiggròs F, 2005, J AGR FOOD CHEM, V53, P6080, DOI 10.1021/jf050343m
   Raza H, 2012, INT J MOL SCI, V13, P16241, DOI 10.3390/ijms131216241
   Reddy JK, 2006, AM J PHYSIOL-GASTR L, V290, pG852, DOI 10.1152/ajpgi.00521.2005
   Richards RJ, 2000, P SOC EXP BIOL MED, V223, P258, DOI 10.1046/j.1525-1373.2000.22336.x
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Sailaja JBK, 2004, PHARMAZIE, V59, P475
   SALMON DMW, 1985, INT J OBESITY, V9, P443
   Scalbert A, 2002, BIOMED PHARMACOTHER, V56, P276, DOI 10.1016/S0753-3322(02)00205-6
   Serkova NJ, 2006, J HEPATOL, V44, P956, DOI 10.1016/j.jhep.2005.07.009
   Serra A., 2013, BR J NUTR, P1
   Serra A, 2010, BRIT J NUTR, V103, P944, DOI 10.1017/S0007114509992741
   Shrivastava A, 2013, LIPIDS, V48, P597, DOI 10.1007/s11745-012-3753-3
   Soltys K, 2001, HEPATOLOGY, V34, P13, DOI 10.1053/jhep.2001.25452
   Tomita K, 2004, AM J PHYSIOL-GASTR L, V287, pG1078, DOI 10.1152/ajpgi.00107.2004
NR 52
TC 33
Z9 38
U1 2
U2 39
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD APR
PY 2014
VL 58
IS 4
BP 727
EP 737
DI 10.1002/mnfr.201300455
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA AF2DA
UT WOS:000334521600008
PM 24338985
DA 2025-06-11
ER

PT J
AU Hernández, J
   Muiño, R
   Benedito, JL
   Abuelo, A
   Castillo, C
AF Hernandez, Joaquin
   Muino, Rodrigo
   Benedito, Jose L.
   Abuelo, A.
   Castillo, Cristina
TI Redox status and oxidative stress in bovine
SO LARGE ANIMAL REVIEW
LA English
DT Article
DE ROS; redox status; internal metabolism; cattle
ID BODY CONDITION SCORE; DAIRY-COWS; CORPUS-LUTEUM; ASSOCIATION; ROLES
AB In the last few years, we have seen a marked increase in the number of articles emphasizing the role of oxidative stress in the pathogenesis of multiple cattle diseases and processes. Since the term oxidative stress (OS), defined as the imbalance between prooxidants and antioxidants, was coined, the physiological and pathological roles of both have also been described. This has shown that understanding the relationship between the two components, known as redox status, is a very useful tool in establishing the health and disease status of cattle. OS has been related to production diseases, metabolic diseases - such as ketosis, fatty liver, and even hypocalcaemia - and reproductive diseases. These include both maternal diseases - like those connected with numerous pathologies such as placental retention, udder oedema, or mastitis - and foetal growth. Finally, the term metabolic stress has been established. It relates OS itself to lipomobilization and immune system dysfunction, similar to the so-called metabolic syndrome in humans. Metabolic stress describes the catabolic response to the alteration of physiological homeostasis and is characterized by excessive lipid mobilization, immune and inflammatory dysfunction, and OS.
C1 [Hernandez, Joaquin; Muino, Rodrigo; Benedito, Jose L.; Castillo, Cristina] Univ Santiago de Compostela, Fac Vet, Dept Anim Pathol, Santiago De Compostela, Spain.
   [Abuelo, A.] Michigan State Univ, Coll Vet Sci, Dept Large Anim Clin Sci, E Lansing, MI 48824 USA.
C3 Universidade de Santiago de Compostela; Michigan State University
RP Hernández, J (corresponding author), Univ Santiago de Compostela, Fac Vet, Dept Anim Pathol, Santiago De Compostela, Spain.
EM joaquin.hernandez@usc.es
RI Muiño Otero, Rodrigo/GRY-6734-2022; Abuelo, Ángel/E-9349-2012; Hernandez
   Bermudez, Joaquin/H-2679-2012; Castillo Rodriguez, Cristina/H-2393-2012
OI Hernandez Bermudez, Joaquin/0000-0002-2588-0089; Castillo Rodriguez,
   Cristina/0000-0002-2467-6406
CR Abuelo A, 2016, J ANIM PHYSIOL AN N, V100, P279, DOI 10.1111/jpn.12365
   Abuelo A, 2015, J ANIM PHYSIOL AN N, V99, P1003, DOI 10.1111/jpn.12273
   Abuelo A, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8010020
   Al-Gubory KH, 2012, REPROD BIOMED ONLINE, V25, P551, DOI 10.1016/j.rbmo.2012.08.004
   Atakisi O, 2010, RES VET SCI, V89, P10, DOI 10.1016/j.rvsc.2010.01.008
   Bacha F., 2020, NUTRINEWS, P31
   Bernabucci U, 2005, J DAIRY SCI, V88, P2017, DOI 10.3168/jds.S0022-0302(05)72878-2
   Boulanger V, 2007, CAN J VET RES, V71, P52
   Castillo C, 2001, ARCH MED VET, V33, P5, DOI 10.4067/S0301-732X2001000100001
   Chastant S, 2019, ANIM REPROD, V16, P539, DOI [10.21451/1984-3143-ar2019-0057, 10.21451/1984-3143-AR2019-0057]
   Gross JJ, 2019, ANIMAL, V13, pS75, DOI [10.1017/S175173111800349X, 10.1017/s175173111800349x]
   Halliwell B., 2007, Free Radicals in Biology and Medicine, V5th, P77
   Herb M, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10020313
   Krumm CS, 2017, J DAIRY SCI, V100, P9418, DOI 10.3168/jds.2017-13274
   Kuru M., 2021, SEX HORMONES NEURODE, P304
   Kweh MF, 2021, JDS COMMUN, V2, DOI 10.3168/jdsc.2020-0005
   Laliotis GP, 2020, J VET RES, V64, P421, DOI 10.2478/jvetres-2020-0053
   Maldonado-Saavedra O., 2010, Rev. Medica Univ. Veracruzana, V10, P32
   Nelson CD, 2012, NUTRIENTS, V4, P181, DOI 10.3390/nu4030181
   Nezhdanov A. G., 2016, Sel'skokhozyaistvennaya Biologiya, P230, DOI [10.15389/agrobiology.2016.2.230eng, 10.15389/agrobiology.2016.2.230rus]
   Radi R., 2014, ANALES FACULTAD MEDI, V1, P9
   Radi R, 2018, P NATL ACAD SCI USA, V115, P5839, DOI 10.1073/pnas.1804932115
   Rizzo A, 2012, REPROD DOMEST ANIM, V47, P344, DOI 10.1111/j.1439-0531.2011.01891.x
   Schieber M, 2014, CURR BIOL, V24, pR453, DOI 10.1016/j.cub.2014.03.034
   Shen TY, 2019, J DAIRY SCI, V102, P10554, DOI 10.3168/jds.2019-16706
   Sies H., 1985, OXIDATIVE STRESS, P1, DOI DOI 10.1016/B978-0-12-642760-8.50005-3
   Sies H., 2007, ENCY STRESS, P45
   Sohel MMH, 2019, CELL TISSUE RES, V376, P295, DOI 10.1007/s00441-019-02990-3
   Sordillo LM, 2005, LIVEST PROD SCI, V98, P89, DOI 10.1016/j.livprodsci.2005.10.017
   Sordillo LM, 2009, VET IMMUNOL IMMUNOP, V128, P104, DOI 10.1016/j.vetimm.2008.10.305
   Turk R, 2013, ANIM REPROD SCI, V141, P109, DOI 10.1016/j.anireprosci.2013.07.014
   Turk R, 2017, MLJEKARSTVO, V67, P91, DOI 10.15567/mljekarstvo.2017.0201
   Urh C, 2019, J DAIRY SCI, V102, P6672, DOI 10.3168/jds.2019-16248
   Vailati-Riboni M, 2016, J DAIRY SCI, V99, P758, DOI 10.3168/jds.2015-10046
   Vu HV, 2014, ANIM REPROD, V11, P74
NR 35
TC 2
Z9 2
U1 0
U2 2
PU SIVAR-SOC ITALIANA VETERINARI ANIMALI REDDITO
PI CREMONA
PA VIA TRECCHI 20, CREMONA, 26100, ITALY
SN 1124-4593
J9 LARGE ANIM REV
JI Large Anim. Rev.
PD JUN
PY 2022
VL 28
IS 3
BP 145
EP 151
PG 7
WC Agriculture, Dairy & Animal Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA A0HB2
UT WOS:000952013700006
DA 2025-06-11
ER

PT J
AU Alciati, A
   Caldirola, D
   Grassi, M
   Foschi, D
   Perna, G
AF Alciati, Alessandra
   Caldirola, Daniela
   Grassi, Massimiliano
   Foschi, Diego
   Perna, Giampaolo
TI Mediation effect of recent loss events on weight gain in obese people
   who experienced childhood parental death or separation
SO JOURNAL OF HEALTH PSYCHOLOGY
LA English
DT Article
DE childhood trauma; obesity; prior trauma; weight gain
ID STRESSFUL LIFE EVENTS; BODY-MASS INDEX; METABOLIC SYNDROME; MAJOR
   DEPRESSION; RISK-FACTORS; PSYCHOPATHOLOGY; ABUSE; MALTREATMENT;
   DISORDER; ADULTS
AB Adverse events during childhood, including loss of a parent, are related to a higher risk of adult obesity. We investigated whether childhood parental loss is related to adult rapid weight gain through exposition to a later loss event. We assessed the mediation effect of recent loss and non-loss events on the association between childhood loss and rapid weight gain in 138 individuals seeking bariatric surgery. Our results showed that recent loss events mediate the effect of childhood parental loss on rapid weight gain (0.790; p<.001), suggesting the need for specific programs to prevent and treat obesity in individuals with multiple losses.
C1 [Alciati, Alessandra; Caldirola, Daniela; Grassi, Massimiliano; Perna, Giampaolo] FoRiPsi, Hermanas Hosp, Villa San Benedetto Hosp, Via Roma 16, I-22032 Albese Con Cassano, Como, Italy.
   [Foschi, Diego] L Sacco Univ Hosp, Milan, Italy.
   [Perna, Giampaolo] Maastricht Univ, Maastricht, Netherlands.
   [Perna, Giampaolo] Univ Miami, Coral Gables, FL 33124 USA.
C3 University of Milan; Luigi Sacco Hospital; Maastricht University;
   University of Miami
RP Alciati, A (corresponding author), FoRiPsi, Hermanas Hosp, Villa San Benedetto Hosp, Via Roma 16, I-22032 Albese Con Cassano, Como, Italy.
EM alessandra.alciati@libero.it
RI Alciati, Alessandra/M-2298-2019; Foschi, Diego/K-7248-2017; Perna,
   Giampaolo/K-5194-2013
OI Alciati, Alessandra/0000-0002-8971-4696; Foschi,
   Diego/0000-0002-7702-8226; Perna, Giampaolo/0000-0002-8166-0785;
   Caldirola, Daniela/0000-0002-1461-9475
CR Abraham K., 1911, SELECTED PAPERS PSYC, P137
   Agid O, 1999, MOL PSYCHIATR, V4, P163, DOI 10.1038/sj.mp.4000473
   Alciati A, 2007, J AFFECT DISORDERS, V101, P131, DOI 10.1016/j.jad.2006.11.008
   Alciati A, 2016, J LOSS TRAUMA, V21, P213, DOI 10.1080/15325024.2015.1075796
   Alciati A, 2011, INT J PSYCHIAT MED, V41, P155, DOI 10.2190/PM.41.2.e
   Alvarez J, 2007, AM J PREV MED, V33, P28, DOI 10.1016/j.amepre.2007.02.036
   [Anonymous], STANDARD EDITION COM, DOI DOI 10.1037/10934-000
   BOWLBY J, 1977, BRIT J PSYCHIAT, V130, P201, DOI 10.1192/bjp.130.3.201
   BREWIN CR, 1993, PSYCHOL BULL, V113, P82, DOI 10.1037/0033-2909.113.1.82
   Brooke L, 2013, J HEALTH PSYCHOL, V18, P620, DOI 10.1177/1359105312454036
   BROWN GW, 1977, BRIT J PSYCHIAT, V130, P1, DOI 10.1192/bjp.130.1.1
   BROWNE MAO, 1995, AUST NZ J PSYCHIAT, V29, P437
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   Classen CC, 2005, TRAUMA VIOLENCE ABUS, V6, P103, DOI 10.1177/1524838005275087
   Coelho R, 2014, ACTA PSYCHIAT SCAND, V129, P180, DOI 10.1111/acps.12217
   Coid J, 2001, LANCET, V358, P450, DOI 10.1016/S0140-6736(01)05622-7
   Danese A, 2014, MOL PSYCHIATR, V19, P544, DOI 10.1038/mp.2013.54
   Faber A, 2015, J HEALTH PSYCHOL, V20, P511, DOI 10.1177/1359105315573437
   Fava GA., 1982, VERSIONE ITALIANA SC
   Fiedorowicz JG, 2008, ANN CLIN PSYCHIATRY, V20, P131, DOI 10.1080/10401230802177722
   FINLAYJONES R, 1981, PSYCHOL MED, V11, P803, DOI 10.1017/S0033291700041301
   Flegal KM, 2012, JAMA-J AM MED ASSOC, V307, P491, DOI 10.1001/jama.2012.39
   Galic S, 2010, MOL CELL ENDOCRINOL, V316, P129, DOI 10.1016/j.mce.2009.08.018
   Grilo CM, 2005, OBES RES, V13, P123, DOI 10.1038/oby.2005.16
   Hammen C, 2000, J CONSULT CLIN PSYCH, V68, P782, DOI 10.1037/0022-006X.68.5.782
   Harkness KL, 2006, J ABNORM PSYCHOL, V115, P730, DOI 10.1037/0021-843X.115.4.730
   Hass DJ, 2006, CLIN GASTROENTEROL H, V4, P482, DOI 10.1016/j.cgh.2005.12.015
   Jackson TD, 2000, OBES RES, V8, P451, DOI 10.1038/oby.2000.56
   Jacobs JR, 2009, J NERV MENT DIS, V197, P24, DOI 10.1097/NMD.0b013e3181927723
   Jacobs JR, 2000, PSYCHOL MED, V30, P669, DOI 10.1017/S0033291799002020
   KENDLER KS, 1992, ARCH GEN PSYCHIAT, V49, P109
   Kendler KS, 2001, AM J PSYCHIAT, V158, P582, DOI 10.1176/appi.ajp.158.4.582
   Kinon BJ, 2005, J CLIN PSYCHOPHARM, V25, P255, DOI 10.1097/01.jcp.0000161501.65890.22
   Ladd CO, 2000, PROG BRAIN RES, V122, P81
   Laugero KD, 2011, APPETITE, V56, P194, DOI 10.1016/j.appet.2010.11.001
   LISSAU I, 1994, LANCET, V343, P324, DOI 10.1016/S0140-6736(94)91163-0
   LLOYD C, 1980, ARCH GEN PSYCHIAT, V37, P529
   Luppino FS, 2010, ARCH GEN PSYCHIAT, V67, P220, DOI 10.1001/archgenpsychiatry.2010.2
   Maina G, 2008, J AFFECT DISORDERS, V110, P149, DOI 10.1016/j.jad.2007.12.233
   Mikolajczyk RT, 2009, NUTR J, V8, DOI 10.1186/1475-2891-8-31
   Parker G, 1998, PSYCHOL MED, V28, P1263, DOI 10.1017/S0033291798007387
   PAYKEL ES, 1971, ARCH GEN PSYCHIAT, V25, P340, DOI 10.1001/archpsyc.1971.01750160052010
   Pfeffer CR, 2009, INT J PSYCHIAT MED, V39, P215, DOI 10.2190/PM.39.3.a
   Preacher KJ, 2008, BEHAV RES METHODS, V40, P879, DOI 10.3758/BRM.40.3.879
   Slavich GM, 2011, J PSYCHIATR RES, V45, P1146, DOI 10.1016/j.jpsychires.2011.03.004
   Sobel M.E., 1982, SOCIOLOGICAL METHODO, P290, DOI DOI 10.2307/270723
   Spector JA, 2006, WORLD J GASTROENTERO, V12, P6602, DOI 10.3748/wjg.v12.i41.6602
   Steptoe A, 2007, BRAIN BEHAV IMMUN, V21, P901, DOI 10.1016/j.bbi.2007.03.011
   TENNANT C, 1982, PSYCHOL MED, V12, P321, DOI 10.1017/S0033291700046651
   Thompson JK, 1999, INT J EAT DISORDER, V26, P43, DOI 10.1002/(SICI)1098-108X(199907)26:1<43::AID-EAT6>3.0.CO;2-R
   Tyrka AR, 2008, BIOL PSYCHIAT, V63, P1147, DOI 10.1016/j.biopsych.2008.01.011
   Wegman HL, 2009, PSYCHOSOM MED, V71, P805, DOI 10.1097/PSY.0b013e3181bb2b46
   Weinberg RJ, 2013, J CLIN PSYCHIAT, V74, P834, DOI 10.4088/JCP.12m08284
   Williamson DF, 2002, INT J OBESITY, V26, P1075, DOI 10.1038/sj.ijo.0802038
   WONDERLICH S, 1994, J AM ACAD CHILD PSY, V33, P740, DOI 10.1097/00004583-199406000-00015
NR 55
TC 2
Z9 2
U1 0
U2 9
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1359-1053
EI 1461-7277
J9 J HEALTH PSYCHOL
JI J. Health Psychol.
PD JAN
PY 2017
VL 22
IS 1
BP 101
EP 110
DI 10.1177/1359105315595451
PG 10
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA EH0QE
UT WOS:000391468000009
PM 26268512
DA 2025-06-11
ER

PT J
AU Nair, PC
   Chalker, JM
   McKinnon, RA
   Langmead, CJ
   Gregory, KJ
   Bastiampillai, T
AF Nair, Pramod C.
   Chalker, Justin M.
   McKinnon, Ross A.
   Langmead, Christopher J.
   Gregory, Karen J.
   Bastiampillai, Tarun
TI Trace Amine-Associated Receptor 1 (TAAR1): Molecular and Clinical
   Insights for the Treatment of Schizophrenia and Related Comorbidities
SO ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
LA English
DT Article
DE trace amines; antipsychotics; ulotaront; molecular dynamics;
   treatment-resistant schizophrenia; depression
ID PHARMACOLOGY; ACTIVATION; CAPACITY
AB Schizophrenia is a complex and severe mental illness. Current treatments for schizophrenia typically modulate dopaminergic neurotransmission by D2-receptor blockade. While reducing positive symptoms of schizophrenia, current antipsychotic drugs have little clinical effect on negative symptoms and cognitive impairments. For the last few decades, discovery efforts have sought nondopaminergic compounds with the aim to effectively treat the broad symptoms of schizophrenia. In this viewpoint, we provide an overview on trace amine associated receptor-1 (TAAR1), which presents a clinically validated nondopaminergic target for treating schizophrenia and related disorders, with significantly less overall side-effect burden. TAAR1 agonists may also be specifically beneficial for the substance abuse comorbidity and metabolic syndrome that is often present in patients with schizophrenia.
C1 [Chalker, Justin M.] Flinders Univ S Australia, Inst Nanoscale Sci & Technol, Coll Sci & Engn, Adelaide, SA 5042, Australia.
   [Nair, Pramod C.; McKinnon, Ross A.] Flinders Univ S Australia, Coll Med & Publ Hlth, Flinders Hlth & Med Res Inst FHMRI, Adelaide, SA 5042, Australia.
   [Langmead, Christopher J.; Gregory, Karen J.] Monash Univ, Monash Inst Pharmaceut Sci, Drug Discovery Biol & Neurosci & Mental Hlth Ther, Parkville, Vic 3052, Australia.
   [Bastiampillai, Tarun] Monash Univ, Dept Psychiat, Clayton, Vic 3168, Australia.
   [Bastiampillai, Tarun] Flinders Univ S Australia, Coll Med & Publ Hlth, Adelaide, SA 5042, Australia.
   [Nair, Pramod C.] Flinders Univ S Australia, Coll Med & Publ Hlth, Discipline Clin Pharmacol, Adelaide, SA 5042, Australia.
C3 Flinders University South Australia; Flinders University South
   Australia; Monash University; Monash University; Flinders University
   South Australia; Flinders University South Australia
RP Nair, PC (corresponding author), Flinders Univ S Australia, Coll Med & Publ Hlth, Flinders Hlth & Med Res Inst FHMRI, Adelaide, SA 5042, Australia.; Nair, PC (corresponding author), Flinders Univ S Australia, Coll Med & Publ Hlth, Discipline Clin Pharmacol, Adelaide, SA 5042, Australia.
EM pramod.nair@flinders.edu.au
RI McKinnon, Ross/B-9340-2009; Chalker, Justin/E-6965-2011; Bastiampillai,
   Tarun/ABD-9238-2021
OI Chalker, Justin/0000-0002-7504-5508; Bastiampillai,
   Tarun/0000-0002-6931-2913; Nair, Pramod/0000-0002-8630-0121; McKinnon,
   Ross/0000-0002-3725-793X; Langmead, Christopher/0000-0003-3483-1120
CR Berry MD, 2017, PHARMACOL THERAPEUT, V180, P161, DOI 10.1016/j.pharmthera.2017.07.002
   Borowsky B, 2001, P NATL ACAD SCI USA, V98, P8966, DOI 10.1073/pnas.151105198
   Bunzow JR, 2001, MOL PHARMACOL, V60, P1181, DOI 10.1124/mol.60.6.1181
   Cichero E, 2013, CHEM BIOL DRUG DES, V81, P509, DOI 10.1111/cbdd.12018
   Dedic N, 2019, J PHARMACOL EXP THER, V371, P1, DOI 10.1124/jpet.119.260281
   Demjaha A, 2012, AM J PSYCHIAT, V169, P1203, DOI 10.1176/appi.ajp.2012.12010144
   Espinoza S, 2015, NEUROPSYCHOPHARMACOL, V40, P2217, DOI 10.1038/npp.2015.65
   Espinoza S, 2011, MOL PHARMACOL, V80, P416, DOI 10.1124/mol.111.073304
   Gainetdinov RR, 2018, PHARMACOL REV, V70, P549, DOI 10.1124/pr.117.015305
   Goff DC, 2020, NEW ENGL J MED, V382, P1555, DOI 10.1056/NEJMe2001508
   Harmeier A, 2015, EUR NEUROPSYCHOPHARM, V25, P2049, DOI 10.1016/j.euroneuro.2015.08.011
   Khokhar JY, 2018, SCHIZOPHR RES, V194, P78, DOI 10.1016/j.schres.2017.04.016
   Kim E, 2017, NEUROPSYCHOPHARMACOL, V42, P941, DOI 10.1038/npp.2016.258
   Koblan KS, 2020, NEW ENGL J MED, V382, P1497, DOI 10.1056/NEJMoa1911772
   Murray RM, 2016, BRIT J PSYCHIAT, V209, P363, DOI 10.1192/bjp.bp.116.182683
   Nair PC, 2022, MOL PSYCHIATR, V27, P88, DOI 10.1038/s41380-021-01250-7
   Nair PC, 2020, MOL PSYCHIATR, V25, P1910, DOI 10.1038/s41380-020-0709-5
   Owen MJ, 2016, LANCET, V388, P86, DOI 10.1016/S0140-6736(15)01121-6
   Tan ES, 2009, ACS CHEM BIOL, V4, P209, DOI 10.1021/cb800304d
NR 19
TC 18
Z9 19
U1 0
U2 4
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
EI 2575-9108
J9 ACS PHARMACOL TRANSL
JI ACS Pharmacol. Transl. Sci.
PD MAR 11
PY 2022
VL 5
IS 3
BP 183
EP 188
DI 10.1021/acsptsci.2c00016
PG 6
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA ZU7YC
UT WOS:000770054900007
PM 35311018
OA Green Published
DA 2025-06-11
ER

PT J
AU Delbosc, S
   Paizanis, E
   Magous, R
   Araiz, C
   Dimo, T
   Cristol, JP
   Cros, G
   Azay, J
AF Delbosc, S
   Paizanis, E
   Magous, R
   Araiz, C
   Dimo, T
   Cristol, JP
   Cros, G
   Azay, J
TI Involvement of oxidative stress and NADPH oxidase activation in the
   development of cardiovascular complications in a model of insulin
   resistance, the fructose-fed rat
SO ATHEROSCLEROSIS
LA English
DT Article
DE oxidative stress; NADPH oxidase; insulin-resistance; cardiovascular
   remodeling; hypertension; fructose-fed rat
ID ENHANCED SUPEROXIDE-PRODUCTION; ANGIOTENSIN-II; CARDIAC-HYPERTROPHY;
   NADH/NADPH OXIDASE; NAD(P)H OXIDASE; HYPERTENSION; SYSTEM; DYSFUNCTION;
   PROGRESSION; PRODUCTS
AB Growing evidences suggest a role of oxidative stress in hypertension and cardiac hypertrophy. The fructose (60%)-fed rat represents a model of metabolic syndrome, associating insulin resistance and high blood pressure. In this model, hypertension, cardiac and vessels hypertrophy and markers of oxidative stress were determined. In addition, the production of reactive oxygen species (ROS) was evaluated at different times after the initiation of fructose-enriched diet in aorta, heart and polymorphonuclear cells. High fructose feeding was associated with an early (1-week) increase in ROS production by aorta, heart and circulatory polymorphonuclear cells, in association with enhanced markers of oxidative stress. Vascular and cardiac hypertrophy was also rapidly observed, while the rise in blood pressure was significant only after 3 weeks. In summary, our study suggests that the production of reactive oxygen species can be a key-event in the initiation and development of cardiovascular complications associated with insulin resistance. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
C1 Inst Univ Rech Clin, Lab Nutr Humaine & Atherogenese, F-34093 Montpellier, France.
   INSERM, Lab Pharmacol & Physiopathol Expt, U376, Fac Pharm, F-34093 Montpellier, France.
C3 Universite de Montpellier; Universite de Montpellier; Institut National
   de la Sante et de la Recherche Medicale (Inserm)
RP Hop Lapeyronie, Biochem Lab, 371 Av Doyen Gaston Giraud, F-34295 Montpellier, France.
EM jp-cristol@chu-montpellier.fr
RI DELBOSC, Sandrine/ABB-4618-2021
OI , Jean-Paul Cristol/0000-0001-8563-7278; Azay-Milhau,
   Jacqueline/0000-0001-9965-9996; Delbosc, Sandrine/0000-0001-8076-6927
CR Al-Awwadi NA, 2004, J AGR FOOD CHEM, V52, P5593, DOI 10.1021/jf049295g
   Baret G, 2002, EXP CLIN ENDOCR DIAB, V110, P298, DOI 10.1055/s-2002-34593
   Bendall JK, 2002, CIRCULATION, V105, P293, DOI 10.1161/hc0302.103712
   Beswick RA, 2001, HYPERTENSION, V38, P1107, DOI 10.1161/hy1101.093423
   Cifuentes ME, 2000, AM J PHYSIOL-HEART C, V279, pH2234, DOI 10.1152/ajpheart.2000.279.5.H2234
   Delbosc S, 2002, J CARDIOVASC PHARM, V40, P611, DOI 10.1097/00005344-200210000-00015
   Delbosc S, 2002, HYPERTENSION, V40, P142, DOI 10.1161/01.HYP.0000024348.87637.6F
   Desouza Cyrus V., 2003, Journal of Cardiovascular Pharmacology and Therapeutics, V8, P297, DOI 10.1177/107424840300800407
   Dobrian AD, 2004, HYPERTENSION, V43, P48, DOI 10.1161/01.HYP.0000103629.01745.59
   Egan BM, 2001, AM J HYPERTENS, V14, p116S, DOI 10.1016/S0895-7061(01)02078-7
   Faure P, 1999, DIABETES, V48, P353, DOI 10.2337/diabetes.48.2.353
   Ferdinandy P, 2000, CIRC RES, V87, P241, DOI 10.1161/01.RES.87.3.241
   Giacchetti G, 2000, J HYPERTENS, V18, P695, DOI 10.1097/00004872-200018060-00006
   Grundy SM, 2002, CIRCULATION, V105, P2696, DOI 10.1161/01.CIR.0000020650.86137.84
   Hansen LL, 1999, J BIOL CHEM, V274, P25078, DOI 10.1074/jbc.274.35.25078
   Inoguchi T, 2000, DIABETES, V49, P1939, DOI 10.2337/diabetes.49.11.1939
   Juan CC, 2001, BIOCHEM BIOPH RES CO, V289, P1328, DOI 10.1006/bbrc.2001.6132
   Kashiwagi A, 1999, DIABETES RES CLIN PR, V45, P199, DOI 10.1016/S0168-8227(99)00062-5
   Lambeth JD, 2000, TRENDS BIOCHEM SCI, V25, P459, DOI 10.1016/S0968-0004(00)01658-3
   Lee KU, 2001, DIABETES RES CLIN PR, V54, pS29, DOI 10.1016/S0168-8227(01)00332-1
   Li JM, 2002, HYPERTENSION, V40, P477, DOI 10.1161/01.HYP.0000032031.30374.32
   MARTINEZ FJ, 1994, HYPERTENSION, V23, P456, DOI 10.1161/01.HYP.23.4.456
   Méchaly I, 1999, J PHARMACOL TOXICOL, V41, P59, DOI 10.1016/S1056-8719(99)00021-0
   Miller AW, 2004, AM J PHYSIOL-REG I, V287, pR157, DOI 10.1152/ajpregu.00647.2003
   PAGANO PJ, 1995, AM J PHYSIOL-HEART C, V268, pH2274, DOI 10.1152/ajpheart.1995.268.6.H2274
   PAMIESANDREU E, 1995, AM J HYPERTENS, V8, P732, DOI 10.1016/0895-7061(95)00118-9
   Park JB, 2002, AM J HYPERTENS, V15, P78, DOI 10.1016/S0895-7061(01)02233-6
   RUGALE C, 2002, AM J PHYSIOL, V5, P5
   Schwedler SB, 2002, KIDNEY INT, V62, P301, DOI 10.1046/j.1523-1755.2002.00423.x
   Shinozaki K, 2000, CIRC RES, V87, P566, DOI 10.1161/01.RES.87.7.566
   Touyz RM, 2001, J HYPERTENS, V19, P1245, DOI 10.1097/00004872-200107000-00009
   Wang HD, 2002, AM J PHYSIOL-HEART C, V282, pH1697, DOI 10.1152/ajpheart.00914.2001
   Wautier MP, 2001, AM J PHYSIOL-ENDOC M, V280, pE685, DOI 10.1152/ajpendo.2001.280.5.E685
   West NEJ, 2001, ARTERIOSCL THROM VAS, V21, P189, DOI 10.1161/01.ATV.21.2.189
   Witko-Sarsat V, 1998, J IMMUNOL, V161, P2524
   Witko-Sarsat W, 2003, KIDNEY INT, V64, P82, DOI 10.1046/j.1523-1755.2003.00044.x
   YAGI K, 1976, BIOCHEM MED METAB B, V15, P212, DOI 10.1016/0006-2944(76)90049-1
   Yasunari K, 2002, HYPERTENSION, V39, P777, DOI 10.1161/hy0302.104670
   Zalba G, 2001, HYPERTENSION, V38, P1395, DOI 10.1161/hy1201.099611
   Zalba G, 2000, HYPERTENSION, V35, P1055, DOI 10.1161/01.HYP.35.5.1055
NR 40
TC 192
Z9 221
U1 0
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD MAR
PY 2005
VL 179
IS 1
BP 43
EP 49
DI 10.1016/j.atherosclerosis.2004.10.018
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 905ME
UT WOS:000227571700005
PM 15721008
DA 2025-06-11
ER

PT J
AU Sakurai, T
   Izawa, T
   Kizaki, T
   Ogasawara, JE
   Shirato, K
   Imaizumi, K
   Takahashi, K
   Ishida, H
   Ohno, H
AF Sakurai, Takuya
   Izawa, Tetsuya
   Kizaki, Takako
   Ogasawara, Jun-Etsu
   Shirato, Ken
   Imaizumi, Kazuhiko
   Takahashi, Kazuto
   Ishida, Hitoshi
   Ohno, Hideki
TI Exercise training decreases expression of inflammation-related
   adipokines through reduction of oxidative stress in rat white adipose
   tissue
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Exercise training; White adipose tissue; Oxidative stress;
   Inflammation-related adipokines; Superoxide dismutase; NADPH oxidase
ID NECROSIS-FACTOR-ALPHA; MONOCYTE CHEMOATTRACTANT PROTEIN-1;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; EPIDIDYMAL ADIPOCYTES;
   SUPEROXIDE-DISMUTASE; NOX FAMILY; OBESITY; PATHOPHYSIOLOGY
AB Increased oxidative stress in adipocytes causes dysregulated expression of inflammation-related adipokines. We have examined the effects of exercise training on oxidative stress in rat white adipose tissue (WAT), especially focusing on inflammation-related adipokines. The levels of lipid peroxidation in WAT of exercise-trained (TR) rats were lower than those ill Control (C) rats. The content of manganese-containing Superoxide dismutase in WAT of TR rats was increased as compared with those in C rats. In contrast, the expression of the NADPH oxidase NOX2 protein in WAT was downregulated by exercise training. Moreover, the levels of inflammation-related adipokines, Such as tumor necrosis factor-alpha and monocyte chemoattractant protein-1, in WAT of TR rats were lower than those in C rats. The effects of exercise training were more remarkable in visceral WAT than in subcutaneous. These results Suggest that exercise training decreases the expression of inflammation-related adipokines by reducing oxidative stress in WAT. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Sakurai, Takuya; Kizaki, Takako; Ogasawara, Jun-Etsu; Shirato, Ken; Ohno, Hideki] Kyorin Univ, Sch Med, Dept Mol Predict Med & Sport Sci, Tokyo 1818611, Japan.
   [Imaizumi, Kazuhiko] Waseda Univ, Fac Human Sci, Lab Physiol Sci, Tokorozawa, Saitama 3591192, Japan.
   [Izawa, Tetsuya] Doshisha Univ, Fac Hlth & Sport Sci, Kyoto 6100394, Japan.
   [Takahashi, Kazuto; Ishida, Hitoshi] Kyorin Univ, Sch Med, Dept Internal Med 3, Tokyo 1818611, Japan.
C3 Kyorin University; Waseda University; Doshisha University; Kyorin
   University
RP Sakurai, T (corresponding author), Kyorin Univ, Sch Med, Dept Mol Predict Med & Sport Sci, 6-20-2 Shinkawa, Tokyo 1818611, Japan.
EM sakutaku@kyorin-u.ac.jp
OI Izawa, Tetsuya/0000-0001-5197-9085
FU Ministry of Education, Culture, Sport, Science and Technology of Japan;
   Nakatomi Foundation, Tokyo, Japan; Grants-in-Aid for Scientific Research
   [21300237] Funding Source: KAKEN
FX This work was partially supported by Grants-in-Aid for Specific Project
   Research from the Ministry of Education, Culture, Sport, Science and
   Technology of Japan. We are also grateful for financial Support from the
   Nakatomi Foundation, Tokyo, Japan.
CR Bedard K, 2007, PHYSIOL REV, V87, P245, DOI 10.1152/physrev.00044.2005
   FERRARA N, 2005, REJUV RES, V11, P139
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   HOTAMISLIGIL GS, 1994, P NATL ACAD SCI USA, V91, P4854, DOI 10.1073/pnas.91.11.4854
   Ito A, 2007, J BIOL CHEM, V282, P25445, DOI 10.1074/jbc.M701549200
   IZAWA T, 1988, BIOCHEM BIOPH RES CO, V151, P1262, DOI 10.1016/S0006-291X(88)80502-3
   Ji LL, 2008, FREE RADICAL BIO MED, V44, P142, DOI 10.1016/j.freeradbiomed.2007.02.031
   Kamei N, 2006, J BIOL CHEM, V281, P26602, DOI 10.1074/jbc.M601284200
   Kanda H, 2006, J CLIN INVEST, V116, P1494, DOI 10.1172/JCI26498
   McCubrey JA, 2006, ANTIOXID REDOX SIGN, V8, P1775, DOI 10.1089/ars.2006.8.1775
   Miranda PJ, 2005, AM HEART J, V149, P33, DOI 10.1016/j.ahj.2004.07.013
   Nakao C, 2000, J APPL PHYSIOL, V88, P649, DOI 10.1152/jappl.2000.88.2.649
   Nauseef WM, 2008, J BIOL CHEM, V283, P16961, DOI 10.1074/jbc.R700045200
   OhIshi S, 1997, AM J RESP CRIT CARE, V156, P1579, DOI 10.1164/ajrccm.156.5.96-11035
   Ookawara T, 1998, AM J PHYSIOL-CELL PH, V275, pC840, DOI 10.1152/ajpcell.1998.275.3.C840
   RODBELL M, 1964, J BIOL CHEM, V239, P375
   Röhrdanz E, 2001, BRAIN RES, V900, P128, DOI 10.1016/S0006-8993(01)02277-6
   Sakurai T, 2005, JPN J PHYSIOL, V55, P181, DOI 10.2170/jjphysiol.R2096
   Sakurai T, 2008, BIOSCI BIOTECH BIOCH, V72, P463, DOI 10.1271/bbb.70567
   Sakurai T, 2007, METABOLISM, V56, P1270, DOI 10.1016/j.metabol.2007.05.014
   Sautin YY, 2007, AM J PHYSIOL-CELL PH, V293, pC584, DOI 10.1152/ajpcell.00600.2006
   Wajchenberg BL, 2000, ENDOCR REV, V21, P697, DOI 10.1210/er.21.6.697
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
NR 25
TC 49
Z9 61
U1 1
U2 7
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD FEB 6
PY 2009
VL 379
IS 2
BP 605
EP 609
DI 10.1016/j.bbrc.2008.12.127
PG 5
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 401FF
UT WOS:000262924300084
PM 19121629
DA 2025-06-11
ER

PT J
AU Onumah, N
   Kircik, LH
AF Onumah, Neh
   Kircik, Leon H.
TI Psoriasis and Its Comorbidities
SO JOURNAL OF DRUGS IN DERMATOLOGY
LA English
DT Article
ID METABOLIC SYNDROME; ARTHRITIS; RISK; DEPRESSION; MORTALITY; PREVALENCE;
   MORBIDITY; FATIGUE; DISEASE
AB Psoriasis is a multi-systemic chronic inflammatory skin disease targeting 2% to 3% of the general population. It is a prototype of immune dysregulation mediated by TH1 proinflammatory cytokines such as TNF-alpha, IFN-Y, IL-6, and IL-12, to name a few. Psoriasis, traditionally viewed as an inflammatory skin disorder of unknown origin, is increasingly recognized as an inflammatory skin disease with far reaching systemic effects. There is growing and emerging evidence that psoriasis patients have a higher prevalence of associated comorbid disease with cardiometabolic dysfunction and psoriatic arthritis being at the forefront. It appears that psoriatic skin disease severity portends a serious risk for development of these comorbidities. As such, patients with moderate to severe psoriatic skin disease are found to have a higher association with these extracutaneous disease manifestations.
C1 [Onumah, Neh] Graves Dermacare Ctr PC, Philadelphia, PA USA.
   [Kircik, Leon H.] Mt Sinai Med Ctr, New York, NY 10029 USA.
   [Kircik, Leon H.] Indiana Univ Sch Med, Indianapolis, IN USA.
C3 Icahn School of Medicine at Mount Sinai; Indiana University System;
   Indiana University Bloomington
RP Onumah, N (corresponding author), Phys Skin Care, 1169 Eastern Pkwy,Ste 2310, Louisville, KY 40217 USA.
EM wedoderm@yahoo.com
CR Abuabara K, 2010, BRIT J DERMATOL, V163, P586, DOI 10.1111/j.1365-2133.2010.09941.x
   Akay A, 2002, J EUR ACAD DERMATOL, V16, P347, DOI 10.1046/j.1468-3083.2002.00467.x
   Boehncke WH, 2008, J DTSCH DERMATOL GES, V6, P622, DOI 10.1111/j.1610-0387.2008.06785.x
   Boehncke Wolf-Henning, 2012, J Rheumatol, V39, P441, DOI 10.3899/jrheum.111245
   Boehncke WH, 2011, EXP DERMATOL, V20, P303, DOI 10.1111/j.1600-0625.2011.01261.x
   De Filippis LG, 2005, INT J TISSUE REACT, V27, P159
   Di Cesare A, 2009, J INVEST DERMATOL, V129, P1339, DOI 10.1038/jid.2009.59
   Esposito M, 2006, DERMATOLOGY, V212, P123, DOI 10.1159/000090652
   Gelfand JM, 2006, J INVEST DERMATOL, V126, P2194, DOI 10.1038/sj.jid.5700410
   Gelfand JM, 2006, JAMA-J AM MED ASSOC, V296, P1735, DOI 10.1001/jama.296.14.1735
   Girolomoni G, 2009, J EUR ACAD DERMAT S1, V23, P35
   Gisondi P, 2010, DERMATOL THER, V23, P155, DOI 10.1111/j.1529-8019.2010.01310.x
   Gladman DD, 2010, ARTHRITIS RES THER, V12, DOI 10.1186/ar3049
   Gottlieb AB, 2008, J DERMATOL TREAT, V19, P5, DOI 10.1080/09546630701364768
   Gottlieb AB, 2006, J DERMATOL TREAT, V17, P279, DOI 10.1080/09546630600823369
   Gulliver W, 2008, BRIT J DERMATOL, V159, P2, DOI 10.1111/j.1365-2133.2008.08779.x
   Gupta MA, 1998, BRIT J DERMATOL, V139, P846
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Kiortsis DN, 2005, ANN RHEUM DIS, V64, P765, DOI 10.1136/ard.2004.026534
   Kremers HM, 2007, J AM ACAD DERMATOL, V57, P347, DOI 10.1016/j.jaad.2007.02.007
   LEE FI, 1990, AM J GASTROENTEROL, V85, P962
   Love TJ, 2011, ARCH DERMATOL, V147, P419, DOI 10.1001/archdermatol.2010.370
   Mallbris L, 2004, EUR J EPIDEMIOL, V19, P225, DOI 10.1023/B:EJEP.0000020447.59150.f9
   Menter A, 2011, J AM ACAD DERMATOL, V65, P137, DOI 10.1016/j.jaad.2010.11.055
   PATARCA R, 1994, CLIN INFECT DIS, V18, pS147, DOI 10.1093/clinids/18.Supplement_1.S147
   Sharma N, 2001, J DERMATOL, V28, P419, DOI 10.1111/j.1346-8138.2001.tb00003.x
   Shbeeb M, 2000, J RHEUMATOL, V27, P1247
   Sommer DM, 2006, ARCH DERMATOL RES, V298, P321, DOI 10.1007/s00403-006-0703-z
   Taylor W, 2006, ARTHRITIS RHEUM, V54, P2665, DOI 10.1002/art.21972
   Tyring S, 2006, LANCET, V367, P29, DOI 10.1016/S0140-6736(05)67763-X
   Ucak S, 2006, J EUR ACAD DERMATOL, V20, P517, DOI 10.1111/j.1468-3083.2006.01499.x
   Vena GA, 2010, DERMATOL THER, V23, P181, DOI 10.1111/j.1529-8019.2010.01313.x
   Wolf N, 2008, J MED GENET, V45, P114, DOI 10.1136/jmg.2007.053595
NR 33
TC 45
Z9 49
U1 0
U2 3
PU JOURNAL OF DRUGS IN DERMATOLOGY
PI NEW YORK
PA 377 PARK AVE SOUTH, 6TH FLOOR, NEW YORK, NY 10016 USA
SN 1545-9616
J9 J DRUGS DERMATOL
JI J. Drugs Dermatol.
PD MAY
PY 2012
VL 11
IS 5
SU S
BP S5
EP S10
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 936ZE
UT WOS:000303628000002
PM 22644770
DA 2025-06-11
ER

PT J
AU Narasimhan, S
   Gokulakrishnan, K
   Sampathkumar, R
   Farooq, S
   Ravikumar, R
   Mohan, V
   Balasubramanyam, M
AF Narasimhan, Sandhya
   Gokulakrishnan, Kuppan
   Sampathkumar, Rangasamy
   Farooq, Syed
   Ravikumar, Radhakrishnan
   Mohan, Viswanathan
   Balasubramanyam, Muthuswamy
TI Oxidative stress is independently associated with non-alcoholic fatty
   liver disease (NAFLD) in subjects with and without type 2 diabetes
SO CLINICAL BIOCHEMISTRY
LA English
DT Article
DE NAFLD; Oxidative stress; Type 2 diabetes; Glutathione; Asian Indians
ID INSULIN-RESISTANCE; LIPID-PEROXIDATION; METABOLIC SYNDROME; HEPATIC
   STEATOSIS; RISK-FACTORS; FOLLOW-UP; STEATOHEPATITIS; PREVALENCE; OXYGEN;
   LIPOTOXICITY
AB Objective: Our work is aimed at exploring the interrelationship of oxidative stress and insulin resistance in NAFLD subjects with and without type 2 diabetes in a population-based study.
   Methods: Subjects [n = 200] were recruited from the Chennai Urban Rural Epidemiology Study. 1: Normal glucose tolerance (NGT) subjects without NAFLD; 2: NGT with NAFLD; 3: type 2 diabetic subjects [T2DM] without NAFLD and 4: T2DM with NAFLD. Thiobarbituric acid reactive substances (TBARS), protein carbonyl (PCC) and glutathione levels were measured by standard methods. Ultrasound of the liver was used to diagnose NAFLD.
   Results: TBARS and PCC levels were significantly elevated and GSH/GSSG ratio was significantly decreased in diabetic subjects with NAFLD compared to all other groups (p trend <0.001). Oxidative stress markers significantly associated with NAFLD even after adjusting for age, gender, BMI and glycemic status.
   Conclusions: Increased oxidative stress is independently associated with NAFLD in Asian Indians without and with T2DM. (c) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
C1 [Balasubramanyam, Muthuswamy] Madras Diabet Res Fdn, Dept Cell & Mol Biol, Madras 600086, Tamil Nadu, India.
   Dr Mohans Diabet Special Ctr, Chennai, Tamil Nadu, India.
C3 Madras Diabetes Research Foundation
RP Balasubramanyam, M (corresponding author), Madras Diabet Res Fdn, Dept Cell & Mol Biol, Madras 600086, Tamil Nadu, India.
EM balusignal@gmail.com
RI Viswanathan, Mohan/C-2321-2009; GOKULAKRISHNAN, KUPPAN/AAT-3244-2020;
   Syed, Farooq/AAK-6781-2020; /B-7510-2009
OI SYED, FAROOQ/0000-0002-0284-0631; /0000-0003-3952-4672; Mohan,
   Viswanathan/0000-0001-5038-6210; GOKULAKRISHNAN,
   KUPPAN/0000-0003-3167-8239; Rangasamy, Sampath/0000-0003-2151-9162
FU Chennai Willingdon Corporate Foundation, Chennai; DBT; DST-FIST, the
   Government of India; Lady Tata Memorial Trust
FX We are grateful to the Chennai Willingdon Corporate Foundation, Chennai
   for the financial support provided for the study. We thank the
   epidemiology team members for conducting the CURES field studies. This
   is the 89th publication of CURES [CURES-89]. Financial assistance from
   DBT and DST-FIST, the Government of India is greatly acknowledged. SN
   also acknowledges the financial assistance from the Lady Tata Memorial
   Trust.
CR Adaikalakoteswari A, 2006, DIABETIC MED, V23, P666, DOI 10.1111/j.1464-5491.2006.01879.x
   Adaikalakoteswari A, 2005, DIABETIC MED, V22, P1151, DOI 10.1111/j.1464-5491.2005.01574.x
   Adams LA, 2005, CAN MED ASSOC J, V172, P899, DOI 10.1503/cmaj.045232
   Adams LA, 2009, AM J GASTROENTEROL, V104, P861, DOI 10.1038/ajg.2009.67
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Ali R, 2009, ANN MED, V41, P265, DOI 10.1080/07853890802552437
   Angulo P, 2006, GASTROENTEROLOGY, V130, P1848, DOI 10.1053/j.gastro.2006.03.041
   Aronis A, 2005, FREE RADICAL BIO MED, V38, P1221, DOI 10.1016/j.freeradbiomed.2005.01.015
   Bellentani S, 2000, ANN INTERN MED, V132, P112, DOI 10.7326/0003-4819-132-2-200001180-00004
   Bergamini CM, 2004, CURR PHARM DESIGN, V10, P1611, DOI 10.2174/1381612043384664
   Browning JD, 2004, J CLIN INVEST, V114, P147, DOI 10.1172/JCI200422422
   Bugianesi E, 2005, DIABETOLOGIA, V48, P634, DOI 10.1007/s00125-005-1682-x
   Chalasani N, 2004, AM J GASTROENTEROL, V99, P1497, DOI 10.1111/j.1572-0241.2004.30159.x
   Cotrim HP, 2005, JAMA-J AM MED ASSOC, V294, P1618, DOI 10.1001/jama.294.13.1618-b
   Das SK, 2008, SCAND J CLIN LAB INV, V68, P323, DOI 10.1080/00365510701673383
   Deepa M, 2003, J Assoc Physicians India, V51, P863
   Diamanti-Kandarakis E, 2004, J CLIN ENDOCR METAB, V89, P1273, DOI 10.1210/jc.2003-031205
   Ekstedt M, 2006, HEPATOLOGY, V44, P865, DOI 10.1002/hep.21327
   Evans JL, 2005, ANTIOXID REDOX SIGN, V7, P1040, DOI 10.1089/ars.2005.7.1040
   Hensley K, 2000, CARCINOGENESIS, V21, P983, DOI 10.1093/carcin/21.5.983
   Hoehn KL, 2009, P NATL ACAD SCI USA, V106, P17787, DOI 10.1073/pnas.0902380106
   Hori M, 2009, LIVER INT, V29, P164, DOI 10.1111/j.1478-3231.2008.01794.x
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   JOSEPH AEA, 1991, CLIN RADIOL, V43, P26, DOI 10.1016/S0009-9260(05)80350-2
   LEVINE RL, 1990, METHOD ENZYMOL, V186, P464
   Lieber CS, 2004, AM J CLIN NUTR, V79, P502
   Lonardo A, 1997, ITAL J GASTROENTEROL, V29, P351
   Madan K, 2006, J CLIN GASTROENTEROL, V40, P930, DOI 10.1097/01.mcg.0000212608.59090.08
   Malhi H, 2008, SEMIN LIVER DIS, V28, P360, DOI 10.1055/s-0028-1091980
   Marchesini G, 2003, HEPATOLOGY, V37, P917, DOI 10.1053/jhep.2003.50161
   Marchesini G, 1999, AM J MED, V107, P450, DOI 10.1016/S0002-9343(99)00271-5
   Marchesini G, 2001, DIABETES, V50, P1844, DOI 10.2337/diabetes.50.8.1844
   MOHAN V, 1986, DIABETOLOGIA, V29, P235, DOI 10.1007/BF00454882
   Mohan V, 2009, DIABETES RES CLIN PR, V84, P84, DOI 10.1016/j.diabres.2008.11.039
   Musso G, 2007, AM J CLIN NUTR, V86, P661, DOI 10.1093/ajcn/86.3.661
   Piemonte F, 2008, J GASTROEN HEPATOL, V23, pE457, DOI 10.1111/j.1440-1746.2007.05070.x
   Prashanth M, 2009, J Assoc Physicians India, V57, P205
   Rodríguez-Hernández H, 2008, EUR J GASTROEN HEPAT, V20, P399, DOI 10.1097/MEG.0b013e3282f448af
   Saadeh S, 2002, GASTROENTEROLOGY, V123, P745, DOI 10.1053/gast.2002.35354
   Sampathkumar R, 2006, MOL CELL BIOCHEM, V282, P169, DOI 10.1007/s11010-006-1740-9
   Sanyal AJ, 2001, GASTROENTEROLOGY, V120, P1183, DOI 10.1053/gast.2001.23256
   Seki S, 2005, HEPATOL RES, V33, P132, DOI 10.1016/j.hepres.2005.09.020
   Seki S, 2002, J HEPATOL, V37, P56, DOI 10.1016/S0168-8278(02)00073-9
   Uslusoy HS, 2009, WORLD J GASTROENTERO, V15, P1863, DOI 10.3748/wjg.15.1863
   VIDELA LA, 2007, FREE RADIC BIOL MED, V37, P1499
   Videla LA, 2006, TRENDS MOL MED, V12, P555, DOI 10.1016/j.molmed.2006.10.001
   YAGI K, 1976, BIOCHEM MED METAB B, V15, P212, DOI 10.1016/0006-2944(76)90049-1
   Yesilova Z, 2005, AM J GASTROENTEROL, V100, P850, DOI 10.1111/j.1572-0241.2005.41500.x
NR 48
TC 98
Z9 111
U1 1
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
EI 1873-2933
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD JUL
PY 2010
VL 43
IS 10-11
BP 815
EP 821
DI 10.1016/j.clinbiochem.2010.04.003
PG 7
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 615KD
UT WOS:000279133100004
PM 20398645
DA 2025-06-11
ER

PT J
AU Pietrzak, A
   Chodorowska, G
   Jazienicka, I
   Osemlak, P
   Wawrzycki, B
   Terlecki, P
   Mieczkowska, J
   Mosiewicz, J
   Zubilewicz, T
   Szubstarski, F
   Krupski, W
   Hercogova, J
   Szepietowski, JC
   Lotti, T
AF Pietrzak, Aldona
   Chodorowska, Grazyna
   Jazienicka, Iwona
   Osemlak, Pawel
   Wawrzycki, Bartlomiej
   Terlecki, Piotr
   Mieczkowska, Jolanta
   Mosiewicz, Jerzy
   Zubilewicz, Tomasz
   Szubstarski, Franciszek
   Krupski, Witold
   Hercogova, Jana
   Szepietowski, Jacek C.
   Lotti, Torello
TI Psoriatic erythroderma coexisting with erythema multiforme-like lesions
   induced by retinoids or retinoids combined with an antibiotic: case
   report
SO DERMATOLOGIC THERAPY
LA English
DT Article
DE erythema multiforme-like lesions; erytroderma; psoriasis; treatment
AB Psoriasis is currently considered a multifactorial disease, which can coexist with many somatic and psychological disorders. We present the case of a 50-year-old woman referred to our department due to erythroderma with concomitant peculiar violaceous, polycyclic lesions most likely induced by medications. Past medical history revealed numerous systemic disorders, including metabolic syndrome, hypertension, cardiac insufficiency, obesity, and depression. Additional examinations and consultations demonstrated dyslipidemia, xanthelasma, incomplete block of the right branch of His bundle, thyreocardiac syndrome, benign adrenal tumor, and delusions. Recently, psoriasis has been intensively studied. We present the case in which erythroderma was most likely triggered by acitretin combined with ceftriaxone. Treatment of many diseases and psychiatric disturbances coexisting with psoriasis is extremely difficult and requires cooperation of various specialists.
C1 [Pietrzak, Aldona; Chodorowska, Grazyna; Jazienicka, Iwona; Wawrzycki, Bartlomiej] Med Univ Lublin, Dept Dermatol Venereol & Pediat Dermatol, PL-20080 Lublin, Poland.
   [Osemlak, Pawel] Med Univ Lublin, Dept Pediat Surg & Traumatol, PL-20080 Lublin, Poland.
   [Terlecki, Piotr; Zubilewicz, Tomasz] Med Univ Lublin, Dept Vasc Surg & Angiol, PL-20080 Lublin, Poland.
   [Mieczkowska, Jolanta; Mosiewicz, Jerzy] Med Univ Lublin, Dept Internal Dis, PL-20080 Lublin, Poland.
   [Krupski, Witold] Med Univ Lublin, Dept Radiol 2, PL-20080 Lublin, Poland.
   [Szubstarski, Franciszek] 1st Mil Hosp, Dept Pathomorphol, Lublin, Poland.
   [Szepietowski, Jacek C.] Wroclaw Med Univ, Dept Dermatol Venereol & Allergol, Wroclaw, Poland.
   [Hercogova, Jana] Charles Univ Prague, Fac Med 2, Dept Dermatol, Prague, Czech Republic.
   [Lotti, Torello] Univ Rome G Marconi, Dept Dermatol & Venereol 2, Rome, Italy.
C3 Medical University of Lublin; Medical University of Lublin; Medical
   University of Lublin; Medical University of Lublin; Medical University
   of Lublin; Wroclaw Medical University; Motol University Hospital;
   Charles University Prague; Guglielmo Marconi University
RP Pietrzak, A (corresponding author), Med Univ Lublin, Dept Dermatol Venereol & Pediat Dermatol, Radziwillowska 13, PL-20080 Lublin, Poland.
EM aldonkapietrzak@tlen.pl
RI Wawrzycki, Bartek/ABC-2803-2020; Chodorowska, Grazyna/A-2415-2019
OI Pietrzak, Aldona/0000-0001-9494-6160; Szepietowski,
   Jacek/0000-0003-0766-6342; Wawrzycki, Bartlomiej/0000-0002-2172-701X;
   Chodorowska, Grazyna/0000-0002-8055-5764; Mosiewicz,
   Jerzy/0000-0003-0320-1863
CR Ahdout J, 2010, J AM ACAD DERMATOL, V62, P874, DOI 10.1016/j.jaad.2009.04.048
   Bowman PH, 2000, CUTIS, V65, P327
   Bryan Matthew E, 2003, J Drugs Dermatol, V2, P315
   Cohen JD, 2007, J RHEUMATOL, V34, P380
   Coimbra S, 2010, J EUR ACAD DERMATOL, V24, P789, DOI 10.1111/j.1468-3083.2009.03527.x
   Cuhadaroglu C, 2000, CUTIS, V65, P327
   Filakovic P, 2009, PSYCHIAT DANUB, V21, P401
   Hayes J, 2010, DERMATOL THER, V23, P174, DOI 10.1111/j.1529-8019.2010.01312.x
   Lotti T, 2010, DERMATOL THER, V23, P119, DOI 10.1111/j.1529-8019.2010.01305.x
   Monteiro R, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/289645
   Oglodek Ewa, 2010, Pol Merkur Lekarski, V28, P53
   Pietrzak A, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/535612
   Prey S, 2010, J EUR ACAD DERMATOL, V24, P23, DOI 10.1111/j.1468-3083.2009.03564.x
   Rocha-Pereira P, 2004, BRIT J DERMATOL, V150, P917, DOI 10.1111/j.1365-2133.2004.05984.x
   Ronpirin C, 2010, AFR J BIOTECHNOL, V9, P1528
   Vos LE, 2007, J AM ACAD DERMATOL, V56, P339, DOI 10.1016/j.jaad.2006.08.006
NR 16
TC 3
Z9 3
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1396-0296
EI 1529-8019
J9 DERMATOL THER
JI Dermatol. Ther.
PD NOV-DEC
PY 2011
VL 24
IS 6
BP 587
EP 590
DI 10.1111/j.1529-8019.2012.01410.x
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 928SQ
UT WOS:000303004600010
PM 22515675
OA gold
DA 2025-06-11
ER

PT J
AU Tarry-Adkins, JL
   Blackmore, HL
   Martin-Gronert, MS
   Fernandez-Twinn, DS
   McConnell, JM
   Hargreaves, IP
   Giussani, DA
   Ozanne, SE
AF Tarry-Adkins, Jane L.
   Blackmore, Heather L.
   Martin-Gronert, Malgorzata S.
   Fernandez-Twinn, Denise S.
   McConnell, Josie M.
   Hargreaves, Iain P.
   Giussani, Dino A.
   Ozanne, Susan E.
TI Coenzyme Q10 prevents accelerated cardiac aging in a rat
   model of poor maternal nutrition and accelerated postnatal growth
SO MOLECULAR METABOLISM
LA English
DT Article
DE Developmental programming; Ubiquinone; Oxidative-stress; DNA damage;
   Telemere length; Cellular senescence
ID OXIDATIVE STRESS; LIFE-SPAN; ANTIOXIDANT PROTECTION;
   MITOCHONDRIAL-FUNCTION; TISSUE CONCENTRATIONS; NITROSATIVE STRESS;
   SAFETY ASSESSMENT; SKELETAL-MUSCLE; STRAND BREAKS; DNA-DAMAGE
AB Studies in human and animals have demonstrated that nutritionally induced low birth-weight followed by rapid postnatal growth increases the risk of metabolic syndrome and cardiovascular disease. Although the mechanisms underlying such nutritional programming are not clearly defined, increased oxidative-stress leading to accelerated cellular aging has been proposed to play an important role. Using an established rodent model of low birth-weight and catch-up growth, we show here that post-weaning dietary supplementation with coenzyme Q(10), a key component of the electron transport chain and a potent antioxidant rescued many of the detrimental effects of nutritional programming on cardiac aging. This included a reduction in nitrosative and oxidative-stress, telomere shortening, DNA damage, cellular senescence and apoptosis. These findings demonstrate the potential for postnatal antioxidant intervention to reverse deleterious phenotypes of developmental programming and therefore provide insight into a potential translatable therapy to prevent cardiovascular disease in at risk humans. (C) 2013 The Authors. Published by Elsevier GmbH. All rights reserved.
C1 [Tarry-Adkins, Jane L.] Univ Cambridge, Metab Res Labs, Cambridge CB2 0QQ, England.
   Addenbrookes Hosp, Addenbrookes Treatment Ctr, MRC Metab Dis Unit, Wellcome Trust MRC Inst Metab Sci, Cambridge CB2 0QQ, England.
   UCL, Natl Hosp, Neurometab Unit, London WC1N 3BG, England.
   Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 0QQ, England.
C3 University of Cambridge; Cambridge University Hospitals NHS Foundation
   Trust; Addenbrooke's Hospital; University of Cambridge; University of
   London; University College London; UCL Medical School; University
   College London Hospitals NHS Foundation Trust; National Hospital for
   Neurology & Neurosurgery; University of Cambridge
RP Tarry-Adkins, JL (corresponding author), Univ Cambridge, Metab Res Labs, Cambridge CB2 0QQ, England.
EM janeadkins@googlemail.com
RI Hargreaves, Iain/AAJ-6757-2020; Fernandez-Twinn, Denise/B-3881-2011
OI Tarry-Adkins, Jane/0000-0001-9569-6132; Ozanne,
   Susan/0000-0001-8753-5144; Giussani, Dino/0000-0002-1308-1204;
   Fernandez-Twinn, Denise/0000-0003-2610-277X
FU British Heart Foundation; Medical Research Council; Department of
   Health's NIHR Biomedical Research Centres at UCLH/UCL; BBSRC
   [BB/E002668/1] Funding Source: UKRI; MRC [MC_UU_12012/4] Funding Source:
   UKRI
FX We would like to thank K. Phillips and A. Wayman for their technical
   expertise. This work was supported by The British Heart Foundation and
   the Medical Research Council. SEO is a British Heart Foundation Senior
   Fellow and a member of the MRC Metabolic Diseases Unit. DAG is a Lister
   Institute Fellow and a Royal Society Wolfson Research Merit Award
   Holder. IPH is supported by the Department of Health's NIHR Biomedical
   Research Centres funding scheme at UCLH/UCL.
CR Angulo J., 2013, TRENDS CELL BIOL, V65C, P380
   BARKER DJP, 1993, DIABETOLOGIA, V36, P62, DOI 10.1007/BF00399095
   BARKER DJP, 1989, LANCET, V2, P577
   BARKER DJP, 1993, LANCET, V341, P938, DOI 10.1016/0140-6736(93)91224-A
   Battista MC, 2005, J PHYSIOL-LONDON, V565, P197, DOI 10.1113/jphysiol.2004.078139
   Belardinelli R, 2005, BIOFACTORS, V25, P137, DOI 10.1002/biof.5520250115
   Bello RI, 2005, EXP GERONTOL, V40, P694, DOI 10.1016/j.exger.2005.07.003
   Bentinger M, 2007, MITOCHONDRION, V7, pS41, DOI 10.1016/j.mito.2007.02.006
   Boitier E, 1998, J NEUROL SCI, V156, P41, DOI 10.1016/S0022-510X(98)00006-9
   Cambonie G, 2007, AM J PHYSIOL-REG I, V292, pR1236, DOI 10.1152/ajpregu.00227.2006
   Castillo AB, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043291
   Corstius HB, 2005, PEDIATR RES, V57, P796, DOI 10.1203/01.PDR.0000157726.65492.CD
   Csiszar A, 2002, CIRC RES, V90, P1159, DOI 10.1161/01.RES.0000020401.61826.EA
   Duncan AJ, 2005, CLIN CHEM, V51, P2380, DOI 10.1373/clinchem.2005.054643
   Eriksson J, 2000, HYPERTENSION, V36, P790, DOI 10.1161/01.HYP.36.5.790
   Eriksson JG, 1999, BMJ-BRIT MED J, V318, P427, DOI 10.1136/bmj.318.7181.427
   ERNSTER L, 1995, BBA-MOL BASIS DIS, V1271, P195, DOI 10.1016/0925-4439(95)00028-3
   Fan L, 2013, INT J OBESITY, V37, P254, DOI 10.1038/ijo.2012.42
   Fotino AD, 2013, AM J CLIN NUTR, V97, P268, DOI 10.3945/ajcn.112.040741
   Giussani D.A., 2013, J DEV ORIGINS HLTH D
   Giussani DA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031017
   Grayson BE, 2010, ENDOCRINOLOGY, V151, P1622, DOI 10.1210/en.2009-1019
   Grünler J, 2004, METHOD ENZYMOL, V378, P3
   Hales CN, 2001, BRIT MED BULL, V60, P5, DOI 10.1093/bmb/60.1.5
   Hangaishi M, 2000, BIOCHEM BIOPH RES CO, V279, P582, DOI 10.1006/bbrc.2000.3973
   Hathcock JN, 2006, REGUL TOXICOL PHARM, V45, P282, DOI 10.1016/j.yrtph.2006.05.006
   Haussmann MF, 2003, P ROY SOC B-BIOL SCI, V270, P1387, DOI 10.1098/rspb.2003.2385
   Hazra TK, 2007, DNA REPAIR, V6, P470, DOI 10.1016/j.dnarep.2006.10.011
   Hidaka T, 2008, BIOFACTORS, V32, P199, DOI 10.1002/biof.5520320124
   Huertas JR, 1999, BIOFACTORS, V9, P337, DOI 10.1002/biof.5520090233
   Ide T, 2000, CIRC RES, V86, P152, DOI 10.1161/01.RES.86.2.152
   Ikematsu H, 2006, REGUL TOXICOL PHARM, V44, P212, DOI 10.1016/j.yrtph.2005.12.002
   Kwong LK, 2002, FREE RADICAL BIO MED, V33, P627, DOI 10.1016/S0891-5849(02)00916-4
   Lee TM, 2011, FREE RADICAL BIO MED, V50, P1461, DOI 10.1016/j.freeradbiomed.2011.01.031
   Leeson CPM, 2001, CIRCULATION, V103, P1264
   Li L., 2007, BIOCH BIOPHYSICAL RE, V13, P715
   Li LQ, 2009, J BIOCHEM, V145, P425, DOI 10.1093/jb/mvp011
   Lim KJ, 2006, PEDIATR RES, V60, P83, DOI 10.1203/01.pdr.0000220361.08181.c3
   Lönnrot K, 1998, BIOCHEM MOL BIOL INT, V44, P727
   MacMillan-Crow LA, 1998, BIOCHEMISTRY-US, V37, P1613, DOI 10.1021/bi971894b
   Mercer JR, 2012, FREE RADICAL BIO MED, V52, P841, DOI 10.1016/j.freeradbiomed.2011.11.026
   Minamino T, 2008, FRONT BIOSCI-LANDMRK, V13, P2971, DOI 10.2741/2902
   Molyneux SL, 2009, NEW ZEAL MED J, V122, P74
   Ochoa JJ, 2005, J GERONTOL A-BIOL, V60, P970, DOI 10.1093/gerona/60.8.970
   Ochoa JJ, 2007, J GERONTOL A-BIOL, V62, P1211, DOI 10.1093/gerona/62.11.1211
   Oikawa S, 1999, FEBS LETT, V453, P365, DOI 10.1016/S0014-5793(99)00748-6
   Quiles JL, 2004, EXP GERONTOL, V39, P189, DOI 10.1016/j.exger.2003.10.002
   Richter T, 2007, EXP GERONTOL, V42, P1039, DOI 10.1016/j.exger.2007.08.005
   Rindler PM, 2013, J BIOL CHEM, V288, P1979, DOI 10.1074/jbc.M112.412890
   Sander S, 2006, J CARD FAIL, V12, P464, DOI 10.1016/j.cardfail.2006.03.007
   Santos-González M, 2007, EXP GERONTOL, V42, P798, DOI 10.1016/j.exger.2007.04.013
   Saretzki G, 2003, AGING CELL, V2, P141, DOI 10.1046/j.1474-9728.2003.00040.x
   Schmelzer C, 2012, J CLIN BIOCHEM NUTR, V50, P119, DOI 10.3164/jcbn.11-19
   Selman C, 2006, MECH AGEING DEV, V127, P897, DOI 10.1016/j.mad.2006.09.008
   Selman Colin, 2013, Biology Letters, V9, P1
   Sen S, 2010, DIABETES, V59, P3058, DOI 10.2337/db10-0301
   Sharpless NE, 2004, J CLIN INVEST, V113, P160, DOI 10.1172/JCI200420761
   Shelley P, 2007, MECH AGEING DEV, V128, P681, DOI 10.1016/j.mad.2007.10.002
   Simmons RA, 2012, BEST PRACT RES CL EN, V26, P701, DOI 10.1016/j.beem.2012.03.012
   Sindhu RK, 2005, LIFE SCI, V76, P945, DOI 10.1016/j.lfs.2004.10.014
   Skilton MR, 2006, CLIN SCI, V111, P281, DOI 10.1042/CS20060036
   SNOECK A, 1990, BIOL NEONATE, V57, P107, DOI 10.1159/000243170
   Speakman JR, 2011, BIOESSAYS, V33, P255, DOI 10.1002/bies.201000132
   Sugamura K, 2011, FREE RADICAL BIO MED, V51, P978, DOI 10.1016/j.freeradbiomed.2011.05.004
   Suzuki YJ, 2004, LIFE SCI, V74, P1829, DOI 10.1016/j.lfs.2003.10.002
   Suzuki YJ, 2003, FREE RADICAL BIO MED, V34, P1589, DOI 10.1016/S0891-5849(03)00208-9
   Tarry-Adkins JL, 2008, FASEB J, V22, P2037, DOI 10.1096/fj.07-099523
   Tarry-Adkins JL, 2009, FASEB J, V23, P1521, DOI 10.1096/fj.08-122796
   Tarry-Adkins JL, 2013, FASEB J, V27, P379, DOI 10.1096/fj.12-218685
   Tarry-Adkins JL, 2011, AM J CLIN NUTR, V94, p1765S, DOI 10.3945/ajcn.110.000620
   Teixeira M, 2012, J PHARM BIOALLIED SC, V4, P76, DOI 10.4103/0975-7406.92743
   van der Loo B, 2000, J EXP MED, V192, P1731, DOI 10.1084/jem.192.12.1731
   Viña J, 2013, ANTIOXID REDOX SIGN, V19, P779, DOI 10.1089/ars.2012.5111
   Von Zglinicki T, 2000, FREE RADICAL BIO MED, V28, P64, DOI 10.1016/S0891-5849(99)00207-5
   Wong LSM, 2010, HEART FAIL REV, V15, P479, DOI 10.1007/s10741-010-9173-7
   Yzydorczyk C, 2008, HYPERTENSION, V52, P889, DOI 10.1161/HYPERTENSIONAHA.108.116251
   Zhang YX, 2012, FREE RADICAL BIO MED, V53, P1531, DOI 10.1016/j.freeradbiomed.2012.07.010
NR 77
TC 36
Z9 38
U1 0
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-8778
J9 MOL METAB
JI Mol. Metab.
PD NOV
PY 2013
VL 2
IS 4
BP 480
EP 490
DI 10.1016/j.molmet.2013.09.004
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA V42UE
UT WOS:000209637900017
PM 24327963
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU van Jaarsveld, CHM
   Fidler, JA
   Steptoe, A
   Boniface, D
   Wardle, J
AF van Jaarsveld, Cornelia H. M.
   Fidler, Jennifer A.
   Steptoe, Andrew
   Boniface, David
   Wardle, Jane
TI Perceived Stress and Weight Gain in Adolescence: A Longitudinal Analysis
SO OBESITY
LA English
DT Article
ID BODY-MASS INDEX; INSULIN-RESISTANCE; METABOLIC SYNDROME; ABDOMINAL
   OBESITY; WAIST CIRCUMFERENCE; DIETARY RESTRAINT; WHITEHALL-II; WORK
   STRESS; FOOD-INTAKE; JOB STRAIN
AB Although perceived stress has been hypothesized to be a risk factor for obesity, epidemiological studies relating stress to weight gain have shown mixed results. We examined prospective associations between perceived stress and changes in waist circumference and BMI in a large study of adolescents. As part of the Health and Behaviour in Teenagers Study (HABITS), height, weight, and waist circumference were measured annually in 4,065 adolescents aged from 11 to 16. Waist and BMI standard deviation scores (SDS) were used as indices of adiposity. Adolescents completed a measure of perceived stress each year, from which mean stress scores over the 5-year period were also calculated and divided by tertile into lower, moderate, and higher stress. Associations between perceived stress at each year and adiposity 1-4 years later and also adiposity trajectories over the whole period in relation to mean stress were investigated. Analyses were adjusted for age, sex, ethnicity, socioeconomic deprivation, pubertal timing, and smoking. Perceived stress in any year was not related prospectively to increases in waist or BMI SDS 1-4 years later, nor was there any evidence that higher stress over the whole period was associated with greater gains in waist or BMI SDS. However, waist and BMI SDS were significantly higher in the moderate-and higher-stress groups than the lower-stress group across the whole 5-year period. Persistent stress was associated with higher waist circumference and BMI in adolescence, but did not lead to differential changes over 5 years.
C1 [van Jaarsveld, Cornelia H. M.; Fidler, Jennifer A.; Boniface, David; Wardle, Jane] UCL, Dept Epidemiol & Publ Hlth, Hlth Behav Res Ctr, London, England.
   [Steptoe, Andrew] UCL, Dept Epidemiol & Publ Hlth, Psychobiol Grp, London, England.
C3 University of London; University College London; University of London;
   University College London
RP Wardle, J (corresponding author), UCL, Dept Epidemiol & Publ Hlth, Hlth Behav Res Ctr, London, England.
EM j.wardle@ucl.ac.uk
RI Fidler, Jennifer/B-5832-2009; Boniface, David/C-1490-2008; Steptoe,
   Andrew/Y-2440-2019; Van Jaarsveld, Cornelia HM/A-4632-2016
OI Steptoe, Andrew/0000-0001-7808-4943; Boniface,
   David/0000-0002-0320-5234; Van Jaarsveld, Cornelia
   HM/0000-0002-4269-0041
FU British Heart Foundation
FX This research was supported by Cancer Research UK. A.S. is supported by
   the British Heart Foundation. We gratefully acknowledge the
   participation of the 36 schools and 5,863 students and the work of all
   those involved in collecting the data.
CR Adam TC, 2007, PHYSIOL BEHAV, V91, P449, DOI 10.1016/j.physbeh.2007.04.011
   Bhatnagar S, 2006, J NEUROENDOCRINOL, V18, P13, DOI 10.1111/j.1365-2826.2005.01375.x
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   Brunner EJ, 2007, AM J EPIDEMIOL, V165, P828, DOI 10.1093/aje/kwk058
   Cartwright M, 2003, HEALTH PSYCHOL, V22, P362, DOI 10.1037/0278-6133.22.4.362
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   Charmandari E, 2003, HORM RES, V59, P161, DOI 10.1159/000069325
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   COLE TJ, 1995, ARCH DIS CHILD, V73, P25, DOI 10.1136/adc.73.1.25
   Cole TJ, 2000, BMJ-BRIT MED J, V320, P1240, DOI 10.1136/bmj.320.7244.1240
   Dallman MF, 2005, BRAIN BEHAV IMMUN, V19, P275, DOI 10.1016/j.bbi.2004.11.004
   Dallman MF, 2003, P NATL ACAD SCI USA, V100, P11696, DOI 10.1073/pnas.1934666100
   Eisenmann JC, 2003, AM J HUM BIOL, V15, P786, DOI 10.1002/ajhb.10214
   Fidler JA, 2006, TOB CONTROL, V15, P205, DOI 10.1136/tc.2005.014894
   Fidler JA, 2007, ADDICTION, V102, P1493, DOI 10.1111/j.1360-0443.2007.01910.x
   GODDARD E, 1999, UK NATL SMOKING SURV, V1
   Gunstad J, 2006, PSYCHIAT RES, V142, P31, DOI 10.1016/j.psychres.2005.11.007
   Kaufman D, 2007, DIABETES, V56, P1382, DOI 10.2337/db06-1409
   Kivimäki M, 2006, INT J OBESITY, V30, P982, DOI 10.1038/sj.ijo.0803229
   Kouvonen A, 2005, PSYCHOSOM MED, V67, P577, DOI 10.1097/01.psy.0000170330.08704.62
   Laitinen J, 2002, PREV MED, V34, P29, DOI 10.1006/pmed.2001.0948
   Matsumoto Y, 2006, BRAIN RES, V1115, P155, DOI 10.1016/j.brainres.2006.07.088
   McCarthy HD, 2003, BRIT MED J, V326, P624, DOI 10.1136/bmj.326.7390.624
   McCarthy HD, 2001, EUR J CLIN NUTR, V55, P902, DOI 10.1038/sj.ejcn.1601240
   MELLBIN T, 1989, ACTA PAEDIATR SCAND, V78, P568, DOI 10.1111/j.1651-2227.1989.tb17938.x
   PETERSEN AC, 1988, J YOUTH ADOLESCENCE, V17, P117, DOI 10.1007/BF01537962
   Pinyerd Belinda, 2005, J Pediatr Nurs, V20, P75, DOI 10.1016/j.pedn.2004.12.011
   Räikkönen K, 2007, DIABETES CARE, V30, P872, DOI 10.2337/dc06-1857
   Roemmich JN, 2002, OBES RES, V10, P1120, DOI 10.1038/oby.2002.152
   Rosenberg B, 2005, PANMINERVA MED, V47, P229
   Rosenfield RL, 2009, PEDIATRICS, V123, P84, DOI 10.1542/peds.2008-0146
   Rosmond R, 1998, J CLIN ENDOCR METAB, V83, P1853, DOI 10.1210/jc.83.6.1853
   Simon AE, 2003, PSYCHOL MED, V33, P1369, DOI 10.1017/S0033291703008390
   Siqueira L, 2000, J ADOLESCENT HEALTH, V27, P399, DOI 10.1016/S1054-139X(00)00167-1
   Steptoe A, 1996, J PSYCHOSOM RES, V41, P171, DOI 10.1016/0022-3999(96)00095-5
   Townsend P, 1988, HLTH DEPRIVATION INE
   van Jaarsveld CHM, 2007, PSYCHOSOM MED, V69, P798, DOI 10.1097/PSY.0b013e3181576106
   Vicennati V, 2000, J CLIN ENDOCR METAB, V85, P4093, DOI 10.1210/jc.85.11.4093
   Wardle J, 2005, BEST PRACT RES CL EN, V19, P421, DOI 10.1016/j.beem.2005.04.006
   Wardle J, 2003, PREV MED, V36, P721, DOI 10.1016/S0091-7435(03)00047-1
   Wardle J, 2000, J PSYCHOSOM RES, V48, P195, DOI 10.1016/S0022-3999(00)00076-3
NR 41
TC 86
Z9 101
U1 0
U2 20
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD DEC
PY 2009
VL 17
IS 12
BP 2155
EP 2161
DI 10.1038/oby.2009.183
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 523RD
UT WOS:000272091200006
PM 19521353
OA Bronze
DA 2025-06-11
ER

PT J
AU D'Alonzo, KT
   Johnson, S
   Fanfan, D
AF D'Alonzo, Karen T.
   Johnson, Shanda
   Fanfan, Dany
TI A Biobehavioral Approach to Understanding Obesity and the Development of
   Obesogenic Illnesses Among Latino Immigrants in the United States
SO BIOLOGICAL RESEARCH FOR NURSING
LA English
DT Article
DE allostatic load; obesity; Latinos; acculturation stress
ID ALLOSTATIC LOAD; ACCULTURATIVE STRESS; METABOLIC SYNDROME; MARIANISMO
   BELIEFS; COPING STRATEGIES; PHYSICAL-ACTIVITY; RISK-FACTOR; HEALTH;
   PREVALENCE; OVERWEIGHT
AB The prevalence of obesity and obesity-related illnesses is higher among Hispanics (Latinos) than other racial and ethnic groups, and rates increase exponentially with the number of years living in the United States. Mounting evidence suggests that the origins of many chronic illnesses among disadvantaged minority groups may lie with cumulative exposure to chronic psychological and physiological stressors through the biobehavioral process of allostatic load (AL). Among immigrant Latinos, acculturation stress may contribute to an increase in AL and thus may be an independent risk factor for the development of obesity and obesogenic illnesses. The purpose of this theoretical article is to present a proposed model of the effects of acculturation stress on AL and obesity among Latino immigrants. Such a model can be useful to guide intervention efforts to decrease obesity among immigrant Latinos by adding education, skill building, and social integration strategies to healthy eating and physical activity to reduce the deleterious impact of acculturation stress.
C1 [D'Alonzo, Karen T.; Johnson, Shanda] Rutgers State Univ, Coll Nursing, Newark, NJ 07102 USA.
   [Fanfan, Dany] Florida Int Univ, Miami, FL 33199 USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Newark; State University System of Florida; Florida
   International University
RP D'Alonzo, KT (corresponding author), Rutgers State Univ, Coll Nursing, Newark, NJ 07102 USA.
EM kdalonzo@rutgers.edu
RI D'Alonzo, Karen/GSM-6563-2022
OI Fanfan, Dany/0000-0003-2802-0364; Johnson, Shanda/0000-0002-9860-6259
FU NINR NIH HHS [K01 NR009381] Funding Source: Medline
CR [Anonymous], 2011, National Health and Nutrition Examination Survey
   [Anonymous], 1936, AM ANTHROPOL
   [Anonymous], FEMINIST THERAPY HIS
   [Anonymous], OB EC PREV FIT NOT F
   [Anonymous], HISP POP 2010 2010 C
   Arbona C, 2010, HISPANIC J BEHAV SCI, V32, P362, DOI 10.1177/0739986310373210
   Beck A.T., 1979, COGNITIVE THERAPY DE
   Berry J W, 1989, Nebr Symp Motiv, V37, P201
   BERRY JW, 1970, J CROSS CULT PSYCHOL, V1, P239, DOI 10.1177/135910457000100303
   Berry JW, 1997, APPL PSYCHOL-INT REV, V46, P5, DOI 10.1111/j.1464-0597.1997.tb01087.x
   Bjorntorp P, 2001, Obes Rev, V2, P73, DOI 10.1046/j.1467-789x.2001.00027.x
   Bodvarsson O. B., 2009, EC MIGRATION THEORY
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   Candib LM, 2007, ANN FAM MED, V5, P547, DOI 10.1370/afm.754
   Caplan Susan, 2007, Policy Polit Nurs Pract, V8, P93, DOI 10.1177/1527154407301751
   Chandola T, 2006, BMJ-BRIT MED J, V332, P521, DOI 10.1136/bmj.38693.435301.80
   CHROUSOS GP, 1992, JAMA-J AM MED ASSOC, V267, P1244, DOI 10.1001/jama.267.9.1244
   D'Alonzo K. T., 2012, OUTCOMES PREDI UNPUB
   D'Alonzo KT, 2010, QUAL RES SPORT EXERC, V2, P229, DOI 10.1080/19398441.2010.488031
   D'Alonzo KT, 2012, J TRANSCULT NURS, V23, P124, DOI 10.1177/1043659611433872
   Das UN, 2002, EXP BIOL MED, V227, P989, DOI 10.1177/153537020222701106
   Dawson BA, 2010, HISPANIC J BEHAV SCI, V32, P216, DOI 10.1177/0739986310364750
   Desjarlais R., 1995, World mental health
   Drewnowski A, 1997, NUTR REV, V55, P31, DOI 10.1111/j.1753-4887.1997.tb01593.x
   Fall CHD, 2011, ANN HUM BIOL, V38, P410, DOI 10.3109/03014460.2011.592513
   Fernald LC, 2007, EUR J CLIN NUTR, V61, P623, DOI 10.1038/sj.ejcn.1602558
   Finch Brian Karl, 2003, J Immigr Health, V5, P109, DOI 10.1023/A:1023987717921
   Franzini Luisa, 2001, Ethnicity and Disease, V11, P496
   Gallo LC, 2011, ANN BEHAV MED, V41, P21, DOI 10.1007/s12160-010-9233-1
   Gangwisch JE, 2005, SLEEP, V28, P1289, DOI 10.1093/sleep/28.10.1289
   Ganzel B., 2008, NEUROIMAGE, V40, P788
   Gianaros PJ, 2007, NEUROIMAGE, V35, P795, DOI 10.1016/j.neuroimage.2006.10.045
   Gianaros PJ, 2009, BIOL PSYCHIAT, V65, P943, DOI 10.1016/j.biopsych.2008.10.007
   Gil R.M., 1996, The Maria paradox
   Gordon-Larsen P., 2002, Obesity Research, V11, P121
   Grundy SM, 2002, CIRCULATION, V105, P2696, DOI 10.1161/01.CIR.0000020650.86137.84
   Gunnar MR, 2001, DEV PSYCHOPATHOL, V13, P515, DOI 10.1017/S0954579401003066
   Heim C, 2000, PSYCHONEUROENDOCRINO, V25, P1, DOI 10.1016/S0306-4530(99)00035-9
   Hovey J D, 2000, Cultur Divers Ethnic Minor Psychol, V6, P134, DOI 10.1037/1099-9809.6.2.134
   Hovey J D, 2000, J Immigr Health, V2, P119, DOI 10.1023/A:1009556802759
   Isreal B., 1990, HLTH BEHAV HLTH ED, P187
   Jones PS, 2003, WESTERN J NURS RES, V25, P835, DOI 10.1177/0193945903256711
   Juniu S, 2000, J LEISURE RES, V32, P358, DOI 10.1080/00222216.2000.11949921
   Kaestner R, 2009, SOC SCI QUART, V90, P1089, DOI 10.1111/j.1540-6237.2009.00648.x
   Kandula NR, 2008, DIABETES CARE, V31, P1621, DOI 10.2337/dc07-2182
   Kaplan M. S., 2004, AM J PHYS ANTHROPOL, V125, P1
   Korenblum W., 2007, MOL PSYCHIATR, V10, P974
   Koya DL, 2007, J GEN INTERN MED, V22, P841, DOI 10.1007/s11606-007-0163-y
   Kurtz-Costes B., 2001, SOCIAL ED, V64, P121
   Malan L, 2006, BIOL PSYCHOL, V72, P305, DOI 10.1016/j.biopsycho.2005.11.010
   Malan NT, 1996, STRESS MEDICINE, V12, P55, DOI 10.1002/(SICI)1099-1700(199601)12:1<55::AID-SMI683>3.3.CO;2-#
   Marin G., 1993, Ethnic identity: Formation and transmission among Hispanics and other minorities, P181
   MARKIDES KS, 1986, PUBLIC HEALTH REP, V101, P253
   Mattei J, 2010, SOC SCI MED, V70, P1988, DOI 10.1016/j.socscimed.2010.02.024
   McEwen B., 2002, END STRESS WE KNOW I
   McEwen BS, 2007, PHYSIOL REV, V87, P873, DOI 10.1152/physrev.00041.2006
   McEwen BS, 2000, NEUROPSYCHOPHARMACOL, V22, P108, DOI 10.1016/S0893-133X(99)00129-3
   McEwen BS, 2003, HORM BEHAV, V43, P2, DOI 10.1016/S0018-506X(02)00024-7
   McEwen BS, 2002, NEUROBIOL AGING, V23, P921, DOI 10.1016/S0197-4580(02)00027-1
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   Mellin L., 2011, HYPOTHESIS J DISCUSS, V9
   MENA FJ, 1987, HISPANIC J BEHAV SCI, V9, P207, DOI 10.1177/07399863870092006
   Miller G, 2007, EXTREME PREMATURITY: PRACTICES, BIOETHICS, AND THE LAW, P25
   Miranda A.O., 2000, J MENTAL HEALTH COUN, V22, P306
   Mokdad AH, 2004, JAMA-J AM MED ASSOC, V291, P1238, DOI 10.1001/jama.291.10.1238
   Mui AC, 2006, SOC WORK, V51, P243, DOI 10.1093/sw/51.3.243
   *NIH, 1998, NIH PUBL, pR11
   Pascual-Leone A, 1999, NEUROPSYCHOLOGIA, V37, P207
   Peek MK, 2010, AM J PUBLIC HEALTH, V100, P940, DOI 10.2105/AJPH.2007.129312
   Pew Hispanic Center, 2011, STAT REP HISP FOR BO
   Popkin BM, 2001, J NUTR, V131, p871S, DOI 10.1093/jn/131.3.871S
   Popkin BM, 1998, J NUTR, V128, P701, DOI 10.1093/jn/128.4.701
   Prentice A M, 2001, Obes Rev, V2, P141, DOI 10.1046/j.1467-789x.2001.00031.x
   Reimann M, 2012, PSYCHOPHYSIOLOGY, V49, P454, DOI 10.1111/j.1469-8986.2011.01328.x
   Rumbaut R. G., 2006, IMMIGRANT AM PORTRAI, V3
   Sapolsky RM, 2000, ENDOCR REV, V21, P55, DOI 10.1210/er.21.1.55
   Seeman T, 2010, AM J HUM BIOL, V22, P463, DOI 10.1002/ajhb.21018
   Selye H., 1975, STRESS LIFE
   Shaw C., 2001, Toward a theory of neuroplasticity
   Shonkoff J. P., 2011, JAMA-J AM MED ASSOC, V306, P2252
   Skuza J. A., 2007, HUMAN STUDIES, V30, P451
   Smedley B.D., 2002, Committee on understanding and Eliminating Racial and Ethnic disparities in Health Care
   Steffen PR, 2006, PSYCHOSOM MED, V68, P386, DOI 10.1097/01.psy.0000221255.48190.32
   Sterling P., 1988, Handbook of life stress, cognition, and health, P629
   Stevens E., 1973, Female and male in Latin America, P89
   Sullivan MM, 2005, ADV NURS SCI, V28, P240, DOI 10.1097/00012272-200507000-00006
   Susman EJ, 2006, NEUROSCI BIOBEHAV R, V30, P376, DOI 10.1016/j.neubiorev.2005.08.002
   Szanton SL, 2005, BIOL RES NURS, V7, P7, DOI 10.1177/1099800405278216
   Taningco M.T. V., 2007, Revisiting the Latino health paradox
   Thoman LV, 2004, HISPANIC J BEHAV SCI, V26, P293, DOI 10.1177/0739986304267993
   Wang YF, 2008, OBESITY, V16, P2323, DOI 10.1038/oby.2008.351
   Wilson M., 2007, INT J INTERCULTURAL, V35, P186
   Wood GE, 2008, BEHAV NEUROSCI, V122, P282, DOI 10.1037/0735-7044.122.2.282
   Wyatt SB, 2006, AM J MED SCI, V331, P166, DOI 10.1097/00000441-200604000-00002
   Yehuda R, 2000, J CLIN PSYCHIAT, V61, P14
   Zhou M, 1997, ANNU REV SOCIOL, V23, P63, DOI 10.1146/annurev.soc.23.1.63
NR 96
TC 26
Z9 38
U1 0
U2 16
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1099-8004
EI 1552-4175
J9 BIOL RES NURS
JI Biol. Res. Nurs.
PD OCT
PY 2012
VL 14
IS 4
SI SI
BP 364
EP 374
DI 10.1177/1099800412457017
PG 11
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 010XD
UT WOS:000309126900005
PM 22923710
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Siegel, G
   Schmidt, A
   Schäfer, P
   Malmsten, M
   Ringstad, L
   Winkler, K
   Just, S
AF Siegel, Guenter
   Schmidt, Annette
   Schaefer, Petra
   Malmsten, Martin
   Ringstad, Lovisa
   Winkler, Karl
   Just, Soeren
TI The importance of scavenging reactive oxygen species in anti-aging
   medicine
SO ENGINEERING IN LIFE SCIENCES
LA English
DT Article
DE Clinical trial; Ellipsometry; Ginkgo biloba; Metabolic syndrome
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; GINKGO-BILOBA EXTRACT;
   CARDIOVASCULAR RISK-FACTORS; RECEPTOR-BASED BIOSENSOR; 3RD
   NATIONAL-HEALTH; METABOLIC SYNDROME; ENDOTHELIAL DYSFUNCTION;
   ANTIOXIDANT ACTIVITY; NANOPLAQUE FORMATION
AB In a pilot Study, we had reported on the beneficial effects of Ginkgo biloba (EGb 761) on arteriosclerotic nanoplaque formation and size in cardiovascular high-risk patients who had undergone an aortocoronary bypass operation. Briefly, nanoplaque formation and size, the ratio oxLDL/LDL, and the highly atherothrombotic lipoprotein(a) concentration were substantially reduced, while superoxide dismutase activity and the blood concentration of the vasodilating substances cAMP and cGMP were Upregulated. Since the arteriosclerosis prophylactic and well-aging promotive impact of Ginkgo extract has been proven in this pilot study, we wanted to confirm these beneficial effects through a second observational clinical trial. The measurable variables formerly used were additionally supplemented by a wide, novel biomarker spectrum, through which the latest parameters and markers of plaque stability and progression, oxidative stress, and inflammation were available. In eleven patients with metabolic syndrome in the initial stage, the reduction of arteriosclerotic nanoplaque formation amounted to 14.3 +/- 2.9% (p<0.0077) and of nanoplaque size to 23.4 +/- 3.7% (p<0.0004), respectively, after 2-(SOD) and glutathione peroxidase (GPx) activities were upregulated by 19.6 +/- 10.0% (p<0.0785) and 11.6 +/- 2.3% (p<0.001), respectively, the quotient oxLDL/LDL lowered by 21.0 +/- 4.3% (p<0.002), and lipoprotein(a) concentration decreased by 26.3 +/- 4.8% (p<0.001) in the patients' blood. The concentration of cAMP and cGMP was augmented by 43.5 +/- 12.0% (p<0.001) and 32.9 +/- 10.4% (p<0.001), respectively. Surprisingly, we found a lowering of the serum Ca2+ concentration by 5.4 +/- 1.6% (p<0.0076) from 2.37 +/- 0.03 to 2.24 +/- 0.04 mmol/L (p<0.0069). Apart from an additional vasodilatory effect, the lowered extracellular Ca2+ concentration affects Could show a favourable development of the biomarkers 8-iso-PGF(2 alpha), oxLDL/LDL, SOD, GPx (oxidative stress), hs-CRP, MPO, TNF alpha TGF beta(1) (inflammatory status) and MMP-9 (plaque stability). The markers selected here are suited to provide a comprehensive risk profile for the prevention of arteriosclerosis. Finally, a multiple regression analysis reveals a basis for a mechanistic explanation of nanoplaque reduction under Ginkgo treatment. The arteriosclerosis inhibiting effect is due to an attenuation of the risk factors oxLDL/LDL, Lp(a), and [Ca2+](o) as well as to a significant increase in the vasodilator cAMP and cGMP concentration. Thus, Ginkgo with its pleiotropic effects should be assigned a fixed rank among the anti-aging medical therapeutics as a prophylactic measure, especially in patients with early-stage metabolic syndrome.
C1 [Siegel, Guenter; Schaefer, Petra; Malmsten, Martin] Charite, Inst Physiol, D-14195 Berlin, Germany.
   [Schmidt, Annette] Univ Munster, Leibniz Inst Arteriosclerosis Res, D-48149 Munster, Germany.
   [Siegel, Guenter; Malmsten, Martin; Ringstad, Lovisa] Uppsala Univ, Dept Phys Chem, Inst Pharm, S-75123 Uppsala, Sweden.
   [Winkler, Karl] Univ Clin Freiburg, Inst Clin Chem, D-79106 Freiburg, Germany.
   [Just, Soeren] Heart Ctr Cottbus, Dept Cardiac Surg, D-03048 Cottbus, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; University of
   Munster; Uppsala University; University of Freiburg
RP Siegel, G (corresponding author), Charite, Inst Physiol, Campus Benjamin Franklin,Arnimallee 22, D-14195 Berlin, Germany.
EM guenter.siegel@charite.de
FU Spitzner Arzneimittel, Germany
FX G. Siegal was partially supporetd by a research grant from Spitzner
   Arzneimittel, Germany.
CR AHLOULAY M, 1995, AM J PHYSIOL-RENAL, V269, pF225, DOI 10.1152/ajprenal.1995.269.2.F225
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   Anber V, 1997, ARTERIOSCL THROM VAS, V17, P2507, DOI 10.1161/01.ATV.17.11.2507
   Arad Y, 2005, J AM COLL CARDIOL, V46, P158, DOI 10.1016/j.jacc.2005.02.088
   Baumann R, 1999, BLOOD, V94, P4314, DOI 10.1182/blood.V94.12.4314.424k16_4314_4320
   BONORDEN WR, 1994, NUTR TOXICOL, V2, P19
   Bridi R, 2001, PHYTOTHER RES, V15, P449, DOI 10.1002/ptr.814
   BROADUS AE, 1970, J CLIN INVEST, V49, P2237, DOI 10.1172/JCI106442
   BURNS NL, 1995, LANGMUIR, V11, P2768, DOI 10.1021/la00007a070
   Camejo G, 1998, ATHEROSCLEROSIS, V139, P205, DOI 10.1016/S0021-9150(98)00107-5
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cook S, 2003, ARCH PEDIAT ADOL MED, V157, P821, DOI 10.1001/archpedi.157.8.821
   Danesh J, 2000, CIRCULATION, V102, P1082, DOI 10.1161/01.CIR.102.10.1082
   Dangas G, 1999, AM J CARDIOL, V83, P583, DOI 10.1016/S0002-9149(98)00917-5
   Davignon J, 2004, CIRCULATION, V109, P27, DOI 10.1161/01.CIR.0000131515.03336.f8
   Davis PH, 2001, CIRCULATION, V104, P2815, DOI 10.1161/hc4601.099486
   DELAFLOTTE S, 1984, BIOMED BIOCHIM ACTA, V43, pS212
   Ford ES, 2005, DIABETES CARE, V28, P2745, DOI 10.2337/diacare.28.11.2745
   Glass CK, 2001, CELL, V104, P503, DOI 10.1016/S0092-8674(01)00238-0
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   HALLIWELL B, 1990, FREE RADICAL RES COM, V9, P1, DOI 10.3109/10715769009148569
   HANEFELD M, 1981, DEUT GESUNDHEITSWES, V36, P545
   Hanefeld M, 2006, HERZ, V31, P246, DOI 10.1007/s00059-006-2798-6
   HENRIKSEN T, 1981, P NATL ACAD SCI-BIOL, V78, P6499, DOI 10.1073/pnas.78.10.6499
   Ilieva I, 2004, EXP EYE RES, V79, P181, DOI 10.1016/j.exer.2004.03.009
   Kameda K, 2003, EUR HEART J, V24, P2180, DOI 10.1016/j.ehj.2003.09.022
   Klebanoff SJ, 2005, J LEUKOCYTE BIOL, V77, P598, DOI 10.1189/jlb.1204697
   KOCH E, 1993, HAMOSTASEOLOGIE, V13, P11
   Koltermann A, 2007, CELL MOL LIFE SCI, V64, P1715, DOI 10.1007/s00018-007-7085-z
   Kong YZ, 2005, ATHEROSCLEROSIS, V178, P207, DOI 10.1016/j.atherosclerosis.2004.08.030
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lippi G, 2007, ATHEROSCLEROSIS, V195, P417, DOI 10.1016/j.atherosclerosis.2007.05.005
   Lotito SB, 2000, BIOCHEM BIOPH RES CO, V276, P945, DOI 10.1006/bbrc.2000.3571
   Lusis AJ, 2004, CIRCULATION, V110, P2066, DOI 10.1161/01.CIR.0000143098.98869.F8
   Lusis AJ, 2004, CIRCULATION, V110, P1868, DOI 10.1161/01.CIR.0000143041.58692.CC
   MALMSTEN M, 1994, J COLLOID INTERF SCI, V166, P333, DOI 10.1006/jcis.1994.1303
   MALMSTEN M, 1994, LANGMUIR, V10, P1274, DOI 10.1021/la00016a048
   MALMSTEN M, 1993, COLLOID SURFACE B, V1, P43, DOI 10.1016/0927-7765(93)80016-R
   Malmsten M, 2000, J COLLOID INTERF SCI, V224, P338, DOI 10.1006/jcis.1999.6689
   MANNING GS, 1969, J CHEM PHYS, V51, P934, DOI 10.1063/1.1672158
   MAO GD, 1993, J BIOL CHEM, V268, P416
   Mattsson N, 2008, EUR HEART J, V29, P784, DOI 10.1093/eurheartj/ehm576
   Mullen MJ, 2001, CIRC RES, V88, P145
   Ninomiya JK, 2004, CIRCULATION, V109, P42, DOI 10.1161/01.CIR.0000108926.04022.0C
   Nomoto Kazumiki, 2003, J Cardiol, V42, P201
   Ozkur MK, 2002, PHOTODERMATOL PHOTO, V18, P117, DOI 10.1034/j.1600-0781.2002.00727.x
   PRYOR MA, 2006, AM J PHYSIOL-REG I, V291, pR491
   Ramharack R, 1998, ARTERIOSCL THROM VAS, V18, P984, DOI 10.1161/01.ATV.18.6.984
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Ren D, 2002, J CARDIOVASC PHARM, V40, P809, DOI 10.1097/00005344-200212000-00001
   ROBAK J, 1988, BIOCHEM PHARMACOL, V37, P837, DOI 10.1016/0006-2952(88)90169-4
   Rodríguez M, 2007, ATHEROSCLEROSIS, V192, P438, DOI 10.1016/j.atherosclerosis.2007.02.021
   ROSS R, 1986, NEW ENGL J MED, V314, P488, DOI 10.1056/NEJM198602203140806
   ROSS R, 1993, NATURE, V362, P801, DOI 10.1038/362801a0
   Sasaki S, 2002, AM J CARDIOL, V89, P386, DOI 10.1016/S0002-9149(01)02257-3
   Satoh M, 2006, INT J CARDIOL, V109, P226, DOI 10.1016/j.ijcard.2005.06.023
   Scäfer P, 2007, ATHEROSCLEROSIS, V195, P419, DOI 10.1016/j.atherosclerosis.2007.05.011
   Scholz M, 1999, EUR J HUM GENET, V7, P169, DOI 10.1038/sj.ejhg.5200290
   Scuteri A, 2005, DIABETES CARE, V28, P882, DOI 10.2337/diacare.28.4.882
   Siegal G, 2002, DESALINATION, V148, P407, DOI 10.1016/S0011-9164(02)00756-7
   Siegel G, 2003, CARDIOVASC RES, V58, P696, DOI 10.1016/S0008-6363(03)00249-9
   Siegel G, 1999, ATHEROSCLEROSIS, V144, P59, DOI 10.1016/S0021-9150(99)00042-8
   Siegel G, 2001, BIOSENS BIOELECTRON, V16, P895, DOI 10.1016/S0956-5663(01)00235-4
   Siegel G, 1996, J AUTONOM NERV SYST, V57, P207, DOI 10.1016/0165-1838(95)00071-2
   SIEGEL G, 2007, ANTIAGING THERAP, V9, P313
   Sies H, 1997, EXP PHYSIOL, V82, P291, DOI 10.1113/expphysiol.1997.sp004024
   Silaste ML, 2004, ARTERIOSCL THROM VAS, V24, P498, DOI 10.1161/01.ATV.0000118012.64932.f4
   Smyth S, 2006, NAT MED, V12, P75, DOI 10.1038/nm0106-75
   Spagnoli LG, 2007, J NUCL MED, V48, P1800, DOI 10.2967/jnumed.107.038661
   STEINBERG D, 1989, NEW ENGL J MED, V320, P915
   Stern S, 2008, CIRCULATION, V117, P122, DOI 10.1161/CIRCULATIONAHA.107.702381
   Taylor AJ, 2005, J AM COLL CARDIOL, V46, P807, DOI 10.1016/j.jacc.2005.05.049
   Thalmann S, 2007, CARDIOVASC RES, V75, P690, DOI 10.1016/j.cardiores.2007.03.008
   TIBERG F, 1994, LANGMUIR, V10, P2294, DOI 10.1021/la00019a045
   Tsimikas S, 2004, CIRCULATION, V109, P3164, DOI 10.1161/01.CIR.0000130844.01174.55
   Tzou WS, 2005, J AM COLL CARDIOL, V46, P457, DOI 10.1016/j.jacc.2005.04.046
   VANACKER SABE, 1995, BIOCHEM BIOPH RES CO, V214, P755, DOI 10.1006/bbrc.1995.2350
   WEISS SJ, 1989, NEW ENGL J MED, V320, P365
   WITZTUM JL, 1994, LANCET, V344, P793, DOI 10.1016/S0140-6736(94)92346-9
   Worthley SG, 2001, MT SINAI J MED, V68, P167
   Yudkin JS, 2000, ATHEROSCLEROSIS, V148, P209, DOI 10.1016/S0021-9150(99)00463-3
   Zhou YH, 2006, MEDIAT INFLAMM, V2006, DOI 10.1155/MI/2006/92642
   [No title captured], Patent No. 0946876
NR 84
TC 8
Z9 9
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1618-0240
EI 1618-2863
J9 ENG LIFE SCI
JI Eng. Life Sci.
PD OCT
PY 2009
VL 9
IS 5
SI SI
BP 363
EP 375
DI 10.1002/elsc.200800112
PG 13
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA 525IE
UT WOS:000272207800002
DA 2025-06-11
ER

PT J
AU Sahar, S
   Sassone-Corsi, P
AF Sahar, Saurabh
   Sassone-Corsi, Paolo
TI Regulation of metabolism: the circadian clock dictates the time
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID REV-ERB-ALPHA; ARNT-LIKE PROTEIN-1; RECIPROCAL REGULATION;
   GLUCOSE-HOMEOSTASIS; HEME-BIOSYNTHESIS; NUCLEAR RECEPTORS; MAMMALIAN
   CLOCK; MOLECULAR CLOCK; SHIFT WORK; TRANSCRIPTION
AB Circadian rhythms occur with a periodicity of approximately 24 h and regulate a wide array of metabolic and physiologic functions. Accumulating epidemiological and genetic evidence indicates that disruption of circadian rhythms can be directly linked to many pathological conditions, including sleep disorders, depression, metabolic syndrome and cancer. Intriguingly, several molecular gears constituting the clock machinery have been found to establish functional interplays with regulators of cellular metabolism. Although the circadian clock regulates multiple metabolic pathways, metabolite availability and feeding behavior can in turn regulate the circadian clock. An in-depth understanding of this reciprocal regulation of circadian rhythms and cellular metabolism may provide insights into the development of therapeutic intervention against specific metabolic disorders.
C1 [Sahar, Saurabh; Sassone-Corsi, Paolo] Univ Calif Irvine, Sch Med, Ctr Epigenet & Metab, Irvine, CA 92697 USA.
C3 University of California System; University of California Irvine
RP Sassone-Corsi, P (corresponding author), Univ Calif Irvine, Sch Med, Ctr Epigenet & Metab, Irvine, CA 92697 USA.
EM psc@uci.edu
FU National Institutes of Health; Institut de la Sante et de la Recherche
   Medicale (France); Sirtris Pharmaceutical Inc.
FX We wish to apologize to all colleagues whose work, because of lack of
   space, could not be cited. We thank all the members of the Sassone-Corsi
   laboratory for helpful discussions. Work in our laboratory is supported
   by the National Institutes of Health, the Institut de la Sante et de la
   Recherche Medicale (France), and Sirtris Pharmaceutical Inc.
CR Adamantidis A, 2009, J PHYSIOL-LONDON, V587, P33, DOI 10.1113/jphysiol.2008.164400
   Akashi M, 2002, MOL CELL BIOL, V22, P1693, DOI 10.1128/MCB.22.6.1693-1703.2002
   Akhtar RA, 2002, CURR BIOL, V12, P540, DOI 10.1016/S0960-9822(02)00759-5
   Aksoy P, 2006, BIOCHEM BIOPH RES CO, V345, P1386, DOI 10.1016/j.bbrc.2006.05.042
   Alenghat T, 2008, NATURE, V456, P997, DOI 10.1038/nature07541
   Arble DM, 2009, OBESITY, V17, P2100, DOI 10.1038/oby.2009.264
   Asher G, 2008, CELL, V134, P317, DOI 10.1016/j.cell.2008.06.050
   BROWN MS, 1979, J BIOL CHEM, V254, P5144
   Bunger MK, 2000, CELL, V103, P1009, DOI 10.1016/S0092-8674(00)00205-1
   Canaple L, 2006, MOL ENDOCRINOL, V20, P1715, DOI 10.1210/me.2006-0052
   Cantó C, 2009, NATURE, V458, P1056, DOI 10.1038/nature07813
   CHEN JJ, 1981, CELL, V26, P117, DOI 10.1016/0092-8674(81)90039-8
   Costa MJ, 2011, J BIOL CHEM, V286, P9063, DOI 10.1074/jbc.M110.164558
   Damiola F, 2000, GENE DEV, V14, P2950, DOI 10.1101/gad.183500
   De Bacquer D, 2009, INT J EPIDEMIOL, V38, P848, DOI 10.1093/ije/dyn360
   Demierre MF, 2005, NAT REV CANCER, V5, P930, DOI 10.1038/nrc1751
   Dioum EM, 2002, SCIENCE, V298, P2385, DOI 10.1126/science.1078456
   Doi M, 2010, NAT MED, V16, P67, DOI 10.1038/nm.2061
   Douris N, 2011, CURR BIOL, V21, P1347, DOI 10.1016/j.cub.2011.07.018
   Eckel-Mahan K, 2009, NAT STRUCT MOL BIOL, V16, P462, DOI 10.1038/nsmb.1595
   Feige JN, 2007, TRENDS CELL BIOL, V17, P292, DOI 10.1016/j.tcb.2007.04.001
   Feng D, 2011, SCIENCE, V331, P1315, DOI 10.1126/science.1198125
   Firsov D, 2010, KIDNEY INT, V78, P640, DOI 10.1038/ki.2010.227
   Fonken LK, 2010, P NATL ACAD SCI USA, V107, P18664, DOI 10.1073/pnas.1008734107
   Fontaine C, 2003, J BIOL CHEM, V278, P37672, DOI 10.1074/jbc.M304664200
   Frescas D, 2005, J BIOL CHEM, V280, P20589, DOI 10.1074/jbc.M412357200
   Gery S, 2007, ONCOGENE, V26, P7916, DOI 10.1038/sj.onc.1210585
   Green CB, 2007, P NATL ACAD SCI USA, V104, P9888, DOI 10.1073/pnas.0702448104
   Grimaldi B, 2010, CELL METAB, V12, P509, DOI 10.1016/j.cmet.2010.10.005
   Gumz ML, 2009, J CLIN INVEST, V119, P2423, DOI 10.1172/JCI36908
   Haigis MC, 2010, ANNU REV PATHOL-MECH, V5, P253, DOI 10.1146/annurev.pathol.4.110807.092250
   Handschin C, 2005, CELL, V122, P505, DOI 10.1016/j.cell.2005.06.040
   Hirayama J, 2007, NATURE, V450, P1086, DOI 10.1038/nature06394
   Imai S, 2000, NATURE, V403, P795, DOI 10.1038/35001622
   Jiang GQ, 2003, AM J PHYSIOL-ENDOC M, V284, pE671, DOI 10.1152/ajpendo.00492.2002
   Kaasik K, 2004, NATURE, V430, P467, DOI 10.1038/nature02724
   Karlsson B, 2001, OCCUP ENVIRON MED, V58, P747, DOI 10.1136/oem.58.11.747
   Kohsaka A, 2007, CELL METAB, V6, P414, DOI 10.1016/j.cmet.2007.09.006
   Lamia KA, 2008, P NATL ACAD SCI USA, V105, P15172, DOI 10.1073/pnas.0806717105
   Lamia KA, 2009, SCIENCE, V326, P437, DOI 10.1126/science.1172156
   Leone TC, 2005, PLOS BIOL, V3, P672, DOI 10.1371/journal.pbio.0030101
   Li X, 2007, MOL CELL, V28, P91, DOI 10.1016/j.molcel.2007.07.032
   Lin JD, 2004, CELL, V119, P121, DOI 10.1016/j.cell.2004.09.013
   Lin JD, 2005, CELL METAB, V1, P361, DOI 10.1016/j.cmet.2005.05.004
   Liu C, 2007, NATURE, V447, P477, DOI 10.1038/nature05767
   Mamontova A, 1998, CIRCULATION, V98, P2738, DOI 10.1161/01.CIR.98.24.2738
   Marcheva B, 2010, NATURE, V466, P627, DOI 10.1038/nature09253
   Miller BH, 2007, P NATL ACAD SCI USA, V104, P3342, DOI 10.1073/pnas.0611724104
   Minami Y, 2009, P NATL ACAD SCI USA, V106, P9890, DOI 10.1073/pnas.0900617106
   Nakahata Y, 2008, CELL, V134, P329, DOI 10.1016/j.cell.2008.07.002
   Nakahata Y, 2009, SCIENCE, V324, P654, DOI 10.1126/science.1170803
   O'Neill JS, 2008, SCIENCE, V320, P949, DOI 10.1126/science.1152506
   Oishi K, 2005, BIOCHEM J, V386, P575, DOI 10.1042/BJ20041150
   Panda S, 2002, CELL, V109, P307, DOI 10.1016/S0092-8674(02)00722-5
   Ponka P, 1999, AM J MED SCI, V318, P241, DOI 10.1097/00000441-199910000-00004
   Preitner N, 2002, CELL, V110, P251, DOI 10.1016/S0092-8674(02)00825-5
   Raghuram S, 2007, NAT STRUCT MOL BIOL, V14, P1207, DOI 10.1038/nsmb1344
   Ramsey KM, 2009, SCIENCE, V324, P651, DOI 10.1126/science.1171641
   Raspé E, 2002, J LIPID RES, V43, P2172, DOI 10.1194/jlr.M200386-JLR200
   Rodgers JT, 2005, NATURE, V434, P113, DOI 10.1038/nature03354
   Rudic RD, 2004, PLOS BIOL, V2, P1893, DOI 10.1371/journal.pbio.0020377
   Sadacca LA, 2011, DIABETOLOGIA, V54, P120, DOI 10.1007/s00125-010-1920-8
   Sahar S, 2011, AGING-US, V3, P794, DOI 10.18632/aging.100368
   Sahar S, 2009, NAT REV CANCER, V9, P886, DOI 10.1038/nrc2747
   SAITO Y, 1991, ARTERIOSCLER THROMB, V11, P816, DOI 10.1161/01.ATV.11.4.816
   Saper CB, 2002, NEURON, V36, P199, DOI 10.1016/S0896-6273(02)00969-8
   Scheer FAJL, 2009, P NATL ACAD SCI USA, V106, P4453, DOI 10.1073/pnas.0808180106
   Schmutz I, 2010, GENE DEV, V24, P345, DOI 10.1101/gad.564110
   Schwer B, 2008, CELL METAB, V7, P104, DOI 10.1016/j.cmet.2007.11.006
   Shimba S, 2005, P NATL ACAD SCI USA, V102, P12071, DOI 10.1073/pnas.0502383102
   Shirogane T, 2005, J BIOL CHEM, V280, P26863, DOI 10.1074/jbc.M502862200
   Sonoda J, 2008, FEBS LETT, V582, P2, DOI 10.1016/j.febslet.2007.11.016
   Sonoda J, 2007, P NATL ACAD SCI USA, V104, P5223, DOI 10.1073/pnas.0611623104
   Tu BP, 2005, SCIENCE, V310, P1152, DOI 10.1126/science.1120499
   Turek FW, 2005, SCIENCE, V308, P1043, DOI 10.1126/science.1108750
   Um JH, 2007, J BIOL CHEM, V282, P20794, DOI 10.1074/jbc.C700070200
   Um JH, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0018450
   Vollmers C, 2009, P NATL ACAD SCI USA, V106, P21453, DOI 10.1073/pnas.0909591106
   Xu KY, 2011, CELL METAB, V13, P639, DOI 10.1016/j.cmet.2011.05.001
   Yang XY, 2006, CELL, V126, P801, DOI 10.1016/j.cell.2006.06.050
   Yin L, 2007, SCIENCE, V318, P1786, DOI 10.1126/science.1150179
   Yoon JC, 2001, NATURE, V413, P131, DOI 10.1038/35093050
   Zhang EE, 2010, NAT MED, V16, P1152, DOI 10.1038/nm.2214
   Zuber AM, 2009, P NATL ACAD SCI USA, V106, P16523, DOI 10.1073/pnas.0904890106
NR 84
TC 159
Z9 181
U1 3
U2 49
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD JAN
PY 2012
VL 23
IS 1
BP 1
EP 8
DI 10.1016/j.tem.2011.10.005
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 881AE
UT WOS:000299450900001
PM 22169754
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ciesielska, K
   Gajewska, M
AF Ciesielska, Karolina
   Gajewska, Malgorzata
TI Fatty Acids as Potent Modulators of Autophagy Activity in White Adipose
   Tissue
SO BIOMOLECULES
LA English
DT Review
DE autophagy; obesity; WAT; fatty acids; ER stress
ID CONJUGATED LINOLEIC-ACID; ENDOPLASMIC-RETICULUM STRESS; QUALITY-CONTROL;
   DIETARY-FAT; ER STRESS; INSULIN-RESISTANCE; BODY-COMPOSITION; OBESITY;
   INFLAMMATION; DEGRADATION
AB A high-fat diet is one of the causative factors of obesity. The dietary profile of fatty acids is also an important variable in developing obesity, as saturated fatty acids are more obesogenic than monounsaturated and polyunsaturated fatty acids. Overweight and obesity are inseparably connected with the excess of adipose tissue in the body, characterized by hypertrophy and hyperplasia of fat cells, which increases the risk of developing metabolic syndrome. Changes observed within hypertrophic adipocytes result in elevated oxidative stress, unfolded protein accumulation, and increased endoplasmic reticulum (ER) stress. One of the processes involved in preservation of cellular homeostasis is autophagy, which is defined as an intracellular lysosome-dependent degradation system that serves to recycle available macromolecules and eliminate damaged organelles. In obesity, activation of autophagy is increased and the process appears to be regulated by different types of dietary fatty acids. This review describes the role of autophagy in adipose tissue and summarizes the current understanding of the effects of saturated and unsaturated fatty acids in autophagy modulation in adipocytes.
C1 [Ciesielska, Karolina; Gajewska, Malgorzata] Warsaw Univ Life Sci WULS, Inst Vet Med, Dept Physiol Sci, SGGW, Nowoursynowska 159b, PL-02776 Warsaw, Poland.
C3 Warsaw University of Life Sciences
RP Ciesielska, K (corresponding author), Warsaw Univ Life Sci WULS, Inst Vet Med, Dept Physiol Sci, SGGW, Nowoursynowska 159b, PL-02776 Warsaw, Poland.
EM karolina_ciesielska@sggw.edu.pl
FU National Science Centre Poland [2018/31/B/NZ9/00658,
   UMO-2018/31/B/NZ9/00658]
FX This review paper was funded by National Science Centre Poland, grant
   number: 2018/31/B/NZ9/00658 (UMO-2018/31/B/NZ9/00658).
CR Ahmed B, 2021, BIOMED PHARMACOTHER, V137, DOI 10.1016/j.biopha.2021.111315
   Ahmed SH, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0699-3
   Al-Bari MAA, 2020, ANN NY ACAD SCI, V1467, P3, DOI 10.1111/nyas.14305
   Albashir AAD, 2020, CLIN MED, V20, pE109, DOI 10.7861/clinmed.2020-0239
   Antunes F, 2018, CLINICS, V73
   Anwar A, 2002, CIRCULATION, V105, P1220, DOI 10.1161/hc1002.105187
   Astrup Arne, 2005, Semin Vasc Med, V5, P40, DOI 10.1055/s-2005-871740
   Baerga R, 2009, AUTOPHAGY, V5, P1118, DOI 10.4161/auto.5.8.9991
   Ballesteros-Alvarez J, 2021, AGING CELL, V20, DOI 10.1111/acel.13431
   Börgeson E, 2012, FASEB J, V26, P4287, DOI 10.1096/fj.12-208249
   Brostow DP, 2012, NAT REV CARDIOL, V9, P634, DOI 10.1038/nrcardio.2012.117
   Caballero B, 2019, ADV NUTR, V10, pS4, DOI 10.1093/advances/nmy055
   Camargo A, 2017, EUR J NUTR, V56, P1621, DOI 10.1007/s00394-016-1208-y
   Carrière A, 2004, J BIOL CHEM, V279, P40462, DOI 10.1074/jbc.M407258200
   Caviglia JM, 2011, J LIPID RES, V52, P1636, DOI 10.1194/jlr.M016931
   Cheng L, 2021, ADIPOCYTE, V10, P48, DOI 10.1080/21623945.2020.1870060
   Chino H, 2020, TRENDS CELL BIOL, V30, P384, DOI 10.1016/j.tcb.2020.02.001
   Choi Y, 2002, BIOCHEM BIOPH RES CO, V294, P785, DOI 10.1016/S0006-291X(02)00554-5
   Condon KJ, 2019, J CELL SCI, V132, DOI 10.1242/jcs.222570
   De Boer AA, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0085037
   de Mello AH, 2018, LIFE SCI, V192, P26, DOI 10.1016/j.lfs.2017.11.019
   Desjardins EM, 2018, CURR DIABETES REP, V18, DOI 10.1007/s11892-018-1049-6
   Dikic I, 2017, ANNU REV BIOCHEM, V86, P193, DOI 10.1146/annurev-biochem-061516-044908
   Doucet E, 1997, EUR J CLIN NUTR, V51, P846, DOI 10.1038/sj.ejcn.1600497
   Engin A, 2017, ADV EXP MED BIOL, V960, P221, DOI 10.1007/978-3-319-48382-5_9
   Engin A, 2017, ADV EXP MED BIOL, V960, P135, DOI 10.1007/978-3-319-48382-5_6
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   Faghfouri AH, 2021, EUR J PHARMACOL, V912, DOI 10.1016/j.ejphar.2021.174562
   Ferhat M, 2019, ANTIOXID REDOX SIGN, V31, P487, DOI 10.1089/ars.2018.7626
   Fernández AF, 2018, NATURE, V558, P136, DOI 10.1038/s41586-018-0162-7
   Fernández-Felipe J, 2022, BIOMEDICINES, V10, DOI 10.3390/biomedicines10081864
   Ferro-Novick S, 2021, TRENDS BIOCHEM SCI, V46, P630, DOI 10.1016/j.tibs.2020.12.013
   Frigolet ME, 2020, GAC MED MEX, V156, P142, DOI 10.24875/GMM.M20000356
   Gatica D, 2018, NAT CELL BIOL, V20, P233, DOI 10.1038/s41556-018-0037-z
   Ghavami S, 2012, BBA-MOL CELL RES, V1823, P2274, DOI 10.1016/j.bbamcr.2012.09.008
   Giordano A, 2013, J LIPID RES, V54, P2423, DOI 10.1194/jlr.M038638
   Golay A, 1997, INT J OBESITY, V21, pS2
   Hara T, 2008, J CELL BIOL, V181, P497, DOI 10.1083/jcb.200712064
   He CC, 2009, ANNU REV GENET, V43, P67, DOI 10.1146/annurev-genet-102808-114910
   Hornung F, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22073456
   Hosokawa N, 2009, MOL BIOL CELL, V20, P1981, DOI 10.1091/mbc.E08-12-1248
   Ibrahim MM, 2010, OBES REV, V11, P11, DOI 10.1111/j.1467-789X.2009.00623.x
   Jacome-Sosa MM, 2014, J NUTR BIOCHEM, V25, P692, DOI 10.1016/j.jnutbio.2014.02.011
   Jansen HJ, 2012, ENDOCRINOLOGY, V153, P5866, DOI 10.1210/en.2012-1625
   Jo J, 2009, PLOS COMPUT BIOL, V5, DOI 10.1371/journal.pcbi.1000324
   Ju LP, 2019, CELL DEATH DIS, V10, DOI 10.1038/s41419-019-1393-8
   Jung CH, 2010, FEBS LETT, V584, P1287, DOI 10.1016/j.febslet.2010.01.017
   Jung CH, 2009, MOL BIOL CELL, V20, P1992, DOI 10.1091/mbc.E08-12-1249
   Karanasios E, 2013, J CELL SCI, V126, P5224, DOI 10.1242/jcs.132415
   Karczewski J, 2018, EUR CYTOKINE NETW, V29, P83, DOI 10.1684/ecn.2018.0415
   Kawai T, 2021, AM J PHYSIOL-CELL PH, V320, pC375, DOI 10.1152/ajpcell.00379.2020
   Kelley NS, 2007, J NUTR, V137, P2599, DOI 10.1093/jn/137.12.2599
   Kennedy A, 2010, J NUTR BIOCHEM, V21, P171, DOI 10.1016/j.jnutbio.2009.08.003
   Kim PK, 2008, P NATL ACAD SCI USA, V105, P20567, DOI 10.1073/pnas.0810611105
   Klionsky DJ, 2021, AUTOPHAGY, V17, P1, DOI 10.1080/15548627.2020.1797280
   Kojta I, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051305
   Komatsu M, 2005, J CELL BIOL, V169, P425, DOI 10.1083/jcb.200412022
   Kuma A, 2004, NATURE, V432, P1032, DOI 10.1038/nature03029
   Lawton GL, 2000, BRIT J NUTR, V83, P473
   Lemmer IL, 2021, MOL METAB, V47, DOI 10.1016/j.molmet.2021.101169
   Li WW, 2012, CELL MOL LIFE SCI, V69, P1125, DOI 10.1007/s00018-011-0865-5
   Liu WJ, 2016, CELL MOL BIOL LETT, V21, DOI 10.1186/s11658-016-0031-z
   Liu ZJ, 2016, CELL DEATH DIS, V7, DOI 10.1038/cddis.2016.388
   Lock AL, 2004, LIPIDS, V39, P1197, DOI 10.1007/s11745-004-1348-6
   López-Vicario C, 2015, P NATL ACAD SCI USA, V112, P536, DOI 10.1073/pnas.1422590112
   Luhr M, 2019, J BIOL CHEM, V294, P8197, DOI 10.1074/jbc.RA118.002829
   Ma NN, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11010055
   Maiese K, 2020, FRONT BIOSCI-LANDMRK, V25, P1925
   Marion-Letellier R, 2016, EUR J PHARMACOL, V785, P44, DOI 10.1016/j.ejphar.2015.11.004
   Marlatt KL, 2017, CURR OBES REP, V6, P389, DOI 10.1007/s13679-017-0283-6
   de Morentin PBM, 2014, CURR MOL MED, V14, P3, DOI 10.2174/1566524013666131118103706
   Mazon JN, 2017, LIFE SCI, V182, P22, DOI 10.1016/j.lfs.2017.06.002
   Melia TJ, 2020, J CELL BIOL, V219, DOI 10.1083/jcb.202002085
   Melo HM, 2019, FRONT NEUROSCI-SWITZ, V13, DOI 10.3389/fnins.2019.00265
   Mirza AZ, 2019, EUR J MED CHEM, V166, P502, DOI 10.1016/j.ejmech.2019.01.067
   Miyagawa K, 2016, AM J PATHOL, V186, P1861, DOI 10.1016/j.ajpath.2016.03.003
   Montanari T, 2017, OBES REV, V18, P495, DOI 10.1111/obr.12520
   Moroni L, 2020, CLIN RHEUMATOL, V39, P1039, DOI 10.1007/s10067-020-04963-2
   Moussavi N, 2008, OBESITY, V16, P7, DOI 10.1038/oby.2007.14
   Nakatogawa H, 2020, NAT REV MOL CELL BIO, V21, P439, DOI 10.1038/s41580-020-0241-0
   Nakatogawa H, 2013, ESSAYS BIOCHEM, V55, P39, DOI [10.1042/bse0550039, 10.1042/BSE0550039]
   Nall JL, 2009, J NUTR, V139, P1279, DOI 10.3945/jn.108.102301
   Nieto-Torres JL, 2021, MOL ASPECTS MED, V82, DOI 10.1016/j.mam.2021.101020
   Nishimura T, 2017, EMBO J, V36, P1719, DOI 10.15252/embj.201695189
   Niso-Santano M, 2015, AUTOPHAGY, V11, P575, DOI 10.1080/15548627.2015.1017222
   Niso-Santano M, 2015, EMBO J, V34, P1025, DOI 10.15252/embj.201489363
   Ntambi JM, 2002, CAN J APPL PHYSIOL, V27, P617, DOI 10.1139/h02-036
   Oteng AB, 2020, ADV NUTR, V11, P697, DOI 10.1093/advances/nmz125
   Oteng AB, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201900385
   Paolella LM, 2020, MOL METAB, V32, P136, DOI 10.1016/j.molmet.2019.12.003
   Phillips CM, 2012, J NUTR, V142, P824, DOI 10.3945/jn.111.153460
   Pohl C, 2019, SCIENCE, V366, P818, DOI 10.1126/science.aax3769
   Prostek A, 2016, PROSTAG OTH LIPID M, V125, P48, DOI 10.1016/j.prostaglandins.2016.04.002
   Prostek A, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-3
   Pugazhenthi S, 2017, BBA-MOL BASIS DIS, V1863, P1037, DOI 10.1016/j.bbadis.2016.04.017
   Qi ZH, 2019, ADV EXP MED BIOL, V1206, P167, DOI 10.1007/978-981-15-0602-4_8
   Robinson WH, 2016, NAT REV RHEUMATOL, V12, P580, DOI 10.1038/nrrheum.2016.136
   Rohde K, 2019, METABOLISM, V92, P37, DOI 10.1016/j.metabol.2018.10.007
   Rosqvist F, 2014, DIABETES, V63, P2356, DOI 10.2337/db13-1622
   Sauvat A, 2018, EBIOMEDICINE, V30, P261, DOI 10.1016/j.ebiom.2018.03.028
   Scheele C, 2020, ENDOCR REV, V41, P53, DOI 10.1210/endrev/bnz007
   Sekar S, 2018, NUTRITION, V54, P144, DOI 10.1016/j.nut.2018.02.018
   Sengupta S, 2010, NATURE, V468, P1100, DOI 10.1038/nature09584
   Singh R, 2009, J CLIN INVEST, V119, P3329, DOI 10.1172/JCI39228
   Sinha R, 2018, BIOL PSYCHOL, V131, P5, DOI 10.1016/j.biopsycho.2017.05.001
   Skurk T, 2007, J CLIN ENDOCR METAB, V92, P1023, DOI 10.1210/jc.2006-1055
   Smith M, 2017, ESSAYS BIOCHEM, V61, P625, DOI 10.1042/EBC20170092
   Son Y, 2020, MOL METAB, V39, DOI 10.1016/j.molmet.2020.101005
   Stenkula KG, 2018, AM J PHYSIOL-REG I, V315, pR284, DOI 10.1152/ajpregu.00257.2017
   Storlien L H, 1998, Curr Opin Clin Nutr Metab Care, V1, P559, DOI 10.1097/00075197-199811000-00014
   Suzuki T, 2017, CELL REP, V18, P2045, DOI 10.1016/j.celrep.2017.01.076
   Tsuchiya A, 2014, J PHARMACOL SCI, V126, P337, DOI 10.1254/jphs.14182FP
   Tu QQ, 2014, ACTA PHARMACOL SIN, V35, P504, DOI 10.1038/aps.2013.170
   van Dijk SJ, 2009, AM J CLIN NUTR, V90, P1656, DOI 10.3945/ajcn.2009.27792
   Wagner N, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9112367
   Wallace RJ, 2007, J LIPID RES, V48, P2247, DOI 10.1194/jlr.M700271-JLR200
   Wang Y, 2019, ADV EXP MED BIOL, V1206, P67, DOI 10.1007/978-981-15-0602-4_3
   Ward C, 2016, BBA-MOL CELL BIOL L, V1861, P269, DOI 10.1016/j.bbalip.2016.01.006
   West DB, 1998, AM J PHYSIOL-REG I, V275, pR667
   Yang ZF, 2010, CURR OPIN CELL BIOL, V22, P124, DOI 10.1016/j.ceb.2009.11.014
   Yeganeh A, 2017, J NUTR BIOCHEM, V49, P123, DOI 10.1016/j.jnutbio.2017.08.003
   Yin JJ, 2015, INT J MOL MED, V35, P932, DOI 10.3892/ijmm.2015.2085
   Yin JJ, 2015, MEDIAT INFLAMM, V2015, DOI 10.1155/2015/272313
   Yu JY, 2019, MEDICINE, V98, DOI [10.1097/MD.0000000000014740, 10.1097/md.0000000000014740]
   Yu L, 2018, AUTOPHAGY, V14, P207, DOI 10.1080/15548627.2017.1378838
   Yuliana A, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20020274
   Zhang KZ, 2010, INT J CLIN EXP MED, V3, P33
   Zhang X, 2020, AUTOPHAGY, V16, P1668, DOI 10.1080/15548627.2019.1703355
   Zhang Y, 2009, P NATL ACAD SCI USA, V106, P19860, DOI 10.1073/pnas.0906048106
   Zhao XN, 2016, MOLECULES, V21, DOI 10.3390/molecules21060705
   Zheng W, 2019, CELL COMMUN SIGNAL, V17, DOI 10.1186/s12964-019-0353-3
   Zhu WQ, 2019, DIABETES METAB SYNDR, V12, P1625, DOI 10.2147/DMSO.S218336
NR 132
TC 18
Z9 18
U1 2
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD FEB
PY 2023
VL 13
IS 2
AR 255
DI 10.3390/biom13020255
PG 20
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 9G7CI
UT WOS:000938306100001
PM 36830623
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Paschou, SA
   Kosmopoulos, M
   Nikas, IP
   Spartalis, M
   Kassi, E
   Goulis, DG
   Lambrinoudaki, I
   Siasos, G
AF Paschou, Stavroula A.
   Kosmopoulos, Marinos
   Nikas, Ilias P.
   Spartalis, Michael
   Kassi, Evanthia
   Goulis, Dimitrios G.
   Lambrinoudaki, Irene
   Siasos, Gerasimos
TI The Impact of Obesity on the Association between Vitamin D Deficiency
   and Cardiovascular Disease
SO NUTRIENTS
LA English
DT Article
DE vitamin D; obesity; cardiovascular disease; atherosclerosis
ID BODY-MASS INDEX; OXIDATIVE STRESS; RISK-FACTORS; CARDIOMETABOLIC RISK;
   25-HYDROXYVITAMIN D; HYPOVITAMINOSIS-D; D SUPPLEMENTATION; CALCIUM;
   MORTALITY; FAT
AB The aim of this article is to review the literature regarding the relationship between vitamin D deficiency and cardiovascular disease (CVD) and its modification in the presence of obesity. Despite the strong association between vitamin D status and cardiovascular outcomes, vitamin D supplementation trials in the general population have failed to decrease the incidence of cardiovascular events and mortality. A comprehensive study of the published literature and a comparison with experimental data lead to the conclusion that obesity, due to its high prevalence and strong association with both vitamin D deficiency and CVD, may act as a critical confounder, which is responsible for the different results on this association. Adoption of a vitamin D preventive supplementation strategy for CVD is unlikely to yield any benefit to the general population. However, it might be particularly useful in obese adults with increased risk for CVD.
C1 [Paschou, Stavroula A.] Natl & Kapodistrian Univ Athens, Aghia Sophia Hosp, Med Sch, Div Endocrinol & Diabet, Athens 11527, Greece.
   [Paschou, Stavroula A.; Nikas, Ilias P.] European Univ Cyprus, Sch Med, CY-2404 Nicosia, Cyprus.
   [Kosmopoulos, Marinos] Univ Minnesota, Sch Med, Dept Med, Div Cardiol, Minneapolis, MN 55455 USA.
   [Spartalis, Michael] Onassis Cardiac Surg Ctr, Div Cardiol, Athens 17674, Greece.
   [Kassi, Evanthia] Natl & Kapodistrian Univ Athens, Dept Biol Chem, Med Sch, Athens 11527, Greece.
   [Goulis, Dimitrios G.] Aristotle Univ Thessaloniki, Med Sch, Dept Obstet & Gynecol, Unit Reprod Endocrinol, Thessaloniki 56403, Greece.
   [Lambrinoudaki, Irene] Natl & Kapodistrian Univ Athens, Med Sch, Dept Obstet & Gynecol, Athens 11526, Greece.
   [Siasos, Gerasimos] Natl & Kapodistrian Univ Athens, Hippokrat Hosp, Med Sch, Dept Cardiol, Athens 11526, Greece.
C3 National & Kapodistrian University of Athens; European University
   Cyprus; University of Minnesota System; University of Minnesota Twin
   Cities; Onassis Cardiac Surgery Center; National & Kapodistrian
   University of Athens; Aristotle University of Thessaloniki; National &
   Kapodistrian University of Athens; National & Kapodistrian University of
   Athens; Hippokration General Hospital
RP Paschou, SA (corresponding author), Natl & Kapodistrian Univ Athens, Aghia Sophia Hosp, Med Sch, Div Endocrinol & Diabet, Athens 11527, Greece.; Paschou, SA (corresponding author), European Univ Cyprus, Sch Med, CY-2404 Nicosia, Cyprus.
EM s.a.paschou@gmail.com; marinos.kosmopoulos@outlook.com.gr;
   i.nikas@euc.ac.cy; msparta@med.uoa.gr; evakassis@gmail.com;
   dimitrios.goulis@gmail.com; ilambrinoudaki@med.uoa.gr;
   gsiasos@med.uoa.gr
RI Goulis, Dimitrios/AAG-4589-2020; Siasos, Gerasimos/AAD-7218-2019;
   Spartalis, Michael/I-1713-2019
OI Siasos, Gerasimos/0000-0001-7601-8870; Nikas, Ilias/0000-0001-8625-2556;
   Spartalis, Michael/0000-0002-7442-838X; Paschou,
   Stavroula/0000-0002-0651-1376; Lambrinoudaki, Irene/0000-0003-1488-2668
CR Afshin A, 2017, NEW ENGL J MED, V377, P13, DOI 10.1056/NEJMoa1614362
   Ahmad FS, 2016, JACC-HEART FAIL, V4, P911, DOI 10.1016/j.jchf.2016.08.001
   Al Mheid I, 2017, J AM COLL CARDIOL, V70, P89, DOI 10.1016/j.jacc.2017.05.031
   Anagnostis P, 2017, JAMA CARDIOL, V2, P1281, DOI 10.1001/jamacardio.2017.2938
   Andersen LB, 2015, J AM HEART ASSOC, V4, DOI 10.1161/JAHA.114.001417
   Andersen SW, 2017, CANCER EPIDEM BIOMAR, V26, P1242, DOI 10.1158/1055-9965.EPI-17-0133
   [Anonymous], 2010, J Am Coll Cardiol
   Antonopoulos AS, 2017, SCI TRANSL MED, V9, DOI 10.1126/scitranslmed.aal2658
   Apostolakis M, 2018, MATURITAS, V115, P1, DOI 10.1016/j.maturitas.2018.05.010
   Araújo J, 2017, INT J OBESITY, V41, P1526, DOI 10.1038/ijo.2017.133
   Bettencourt A, 2018, J STEROID BIOCHEM, V175, P97, DOI 10.1016/j.jsbmb.2016.11.005
   Bonnet L, 2019, J STEROID BIOCHEM, V185, P39, DOI 10.1016/j.jsbmb.2018.07.006
   Caleyachetty R, 2017, J AM COLL CARDIOL, V70, P1429, DOI 10.1016/j.jacc.2017.07.763
   Calle EE, 1999, NEW ENGL J MED, V341, P1097, DOI 10.1056/NEJM199910073411501
   Cano A, 2018, MATURITAS, V107, P7, DOI 10.1016/j.maturitas.2017.10.004
   Cashman KD, 2017, NUTRIENTS, V9, DOI 10.3390/nu9050469
   Cauley JA, 2013, J WOMENS HEALTH, V22, P915, DOI 10.1089/jwh.2013.4270
   Chang E, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040338
   Chen SC, 2016, ARTERIOSCL THROM VAS, V36, P1651, DOI 10.1161/ATVBAHA.116.307586
   Cipriani C, 2014, INT J ENDOCRINOL, V2014, DOI 10.1155/2014/841248
   Codoñer-Franch P, 2012, J PEDIATR-US, V161, P848, DOI 10.1016/j.jpeds.2012.04.046
   de Gonzalez AB, 2010, NEW ENGL J MED, V363, P2211, DOI 10.1056/NEJMoa1000367
   Dylag Hanna, 2014, Rocz Panstw Zakl Hig, V65, P325
   Ellam T, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0088767
   Farhangi MA, 2017, BMC CARDIOVASC DISOR, V17, DOI 10.1186/s12872-017-0597-z
   Faridi KF, 2017, NUTRITION, V38, P85, DOI 10.1016/j.nut.2017.01.008
   Fatima SS, 2015, J PAK MED ASSOC, V65, P1315
   Florez H, 2007, J STEROID BIOCHEM, V103, P679, DOI 10.1016/j.jsbmb.2006.12.032
   FORBES GB, 1983, INT J OBESITY, V7, P99
   Forouhi NG, 2016, DIABETES OBES METAB, V18, P392, DOI 10.1111/dom.12625
   Forrest KYZ, 2011, NUTR RES, V31, P48, DOI 10.1016/j.nutres.2010.12.001
   Geiss LS, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0173428
   Giovannucci E, 2008, ARCH INTERN MED, V168, P1174, DOI 10.1001/archinte.168.11.1174
   Gradinaru D, 2012, AGING CLIN EXP RES, V24, P595, DOI 10.3275/8591
   Gupta GK, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0156857
   Hadjadj L, 2019, MICROVASC RES, V122, P78, DOI 10.1016/j.mvr.2018.11.011
   Heaney RP, 2011, J BONE MINER RES, V26, P455, DOI 10.1002/jbmr.328
   Holick MF, 2004, AM J CLIN NUTR, V80, p1678S, DOI 10.1093/ajcn/80.6.1678S
   Hsia J, 2007, CIRCULATION, V115, P846, DOI 10.1161/CIRCULATIONAHA.106.673491
   Jepsen P, 2004, HEART, V90, P956, DOI 10.1136/hrt.2003.017269
   Jung YS, 2018, NUTR RES, V53, P51, DOI 10.1016/j.nutres.2018.03.008
   Karras S, 2016, EUR J CLIN NUTR, V70, P979, DOI 10.1038/ejcn.2016.12
   Kelly AS, 2010, PEDIATR DIABETES, V11, P552, DOI 10.1111/j.1399-5448.2009.00640.x
   Kouli GM, 2017, NUTR METAB CARDIOVAS, V27, P881, DOI 10.1016/j.numecd.2017.06.015
   Lambrinoudaki I, 2013, NEUROL SCI, V34, P1433, DOI 10.1007/s10072-012-1259-7
   Liu SY, 2019, J NUTR SCI VITAMINOL, V65, P303, DOI 10.3177/jnsv.65.303
   Makariou Stefania E, 2017, Arch Med Sci Atheroscler Dis, V2, pe52, DOI 10.5114/amsad.2017.70504
   Manson JE, 2019, NEW ENGL J MED, V380, P33, DOI [10.1056/NEJMoa1809944, 10.1056/nejmoa1809944]
   Martins David, 2014, Health (Irvine Calif), V6, P1503
   Mason H, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0084445
   MAWER EB, 1972, CLIN SCI, V43, P413, DOI 10.1042/cs0430413
   Miclea A, 2017, BRAIN BEHAV, V7, DOI 10.1002/brb3.761
   O'Keeffe C, 2013, BMJ OPEN, V3, DOI 10.1136/bmjopen-2013-002837
   Osmancevic A, 2015, J PHOTOCH PHOTOBIO B, V149, P224, DOI 10.1016/j.jphotobiol.2015.06.008
   Piepoli MF, 2016, ATHEROSCLEROSIS, V252, P207, DOI [10.1016/j.atherosclerosis.2016.05.037, 10.1177/2047487316653709]
   Pilz S, 2015, HYPERTENSION, V65, P1195, DOI 10.1161/HYPERTENSIONAHA.115.05319
   Pilz S, 2012, J CLIN ENDOCR METAB, V97, pE653, DOI 10.1210/jc.2011-3043
   Plesner JL, 2018, J PEDIATR ENDOCR MET, V31, P53, DOI 10.1515/jpem-2017-0246
   Rontoyanni VG, 2017, NUTRIENTS, V9, DOI 10.3390/nu9020097
   Ross AC, 2011, J CLIN ENDOCR METAB, V96, P53, DOI 10.1210/jc.2010-2704
   Roth DE, 2018, ANN NY ACAD SCI, V1430, P44, DOI 10.1111/nyas.13968
   Salum E, 2013, DIABETES RES CLIN PR, V100, P243, DOI 10.1016/j.diabres.2013.03.008
   Sandfort V, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.116.003621
   Schnatz PF, 2017, OBSTET GYNECOL, V129, P121, DOI 10.1097/AOG.0000000000001774
   Schöttker B, 2014, BMJ-BRIT MED J, V348, DOI 10.1136/bmj.g3656
   Scragg R, 2017, JAMA CARDIOL, V2, P608, DOI 10.1001/jamacardio.2017.0175
   Shafinaz IS, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-2924-1
   Shamardl HA, 2017, AM J MED SCI, V354, P190, DOI 10.1016/j.amjms.2017.04.007
   Siasos G, 2014, CURR PHARM DESIGN, V20, P5914, DOI 10.2174/1381612820666140619122937
   Stokic E, 2015, ANGIOLOGY, V66, P237, DOI 10.1177/0003319714528569
   Sunbul M, 2015, INT J CARDIOVAS IMAG, V31, P765, DOI 10.1007/s10554-015-0622-1
   Targher G, 2007, NUTR METAB CARDIOVAS, V17, P517, DOI 10.1016/j.numecd.2006.04.002
   Vimaleswaran KS, 2013, PLOS MED, V10, DOI 10.1371/journal.pmed.1001383
   Wang EW, 2017, BRIT J NUTR, V118, P11, DOI 10.1017/S000711451700188X
   Wang Y, 2018, NUTR RES, V60, P106, DOI 10.1016/j.nutres.2018.08.006
   Welles CC, 2014, AM J EPIDEMIOL, V179, P1279, DOI 10.1093/aje/kwu059
   Wortsman J, 2000, AM J CLIN NUTR, V72, P690, DOI 10.1093/ajcn/72.3.690
   Yin K, 2015, ARTERIOSCL THROM VAS, V35, P2432, DOI 10.1161/ATVBAHA.115.306132
   Zhang RH, 2017, AM J CLIN NUTR, V105, P810, DOI 10.3945/ajcn.116.140392
   Zittermann A, 2017, EUR HEART J, V38, P2279, DOI 10.1093/eurheartj/ehx235
NR 80
TC 24
Z9 26
U1 1
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2019
VL 11
IS 10
AR 2458
DI 10.3390/nu11102458
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA JP4HG
UT WOS:000498227300199
PM 31615154
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ross, K
   Martin, T
   Chen, E
   Miller, GE
AF Ross, Kharah
   Martin, Tara
   Chen, Edith
   Miller, Gregory E.
TI Social encounters in daily life and 2-year changes in metabolic risk
   factors in young women
SO DEVELOPMENT AND PSYCHOPATHOLOGY
LA English
DT Article
ID CORONARY-HEART-DISEASE; AMBULATORY BLOOD-PRESSURE; PHYSICAL-ACTIVITY;
   CARDIOVASCULAR REACTIVITY; MARITAL CONFLICT; ARTERY-DISEASE;
   MYOCARDIAL-INFARCTION; MENTAL STRESS; CARDIORESPIRATORY FITNESS;
   PSYCHOLOGICAL DISTRESS
AB Research shows that poor social ties increase risks of morbidity and mortality from cardiovascular disease (CVD). However, little is known about the nature of everyday social encounters that give rise to this association, or when in the course of development they begin to shape disease-relevant biological processes. In this study, 122 adolescent females recorded the qualities of their everyday social interactions using electronic diaries. At the same time we measured components of the metabolic syndrome, a precursor to CVD that includes central adiposity, high blood pressure, insulin resistance, and lipid dysregulation. Metabolic symptoms were reassessed 12 and 24 months later. Hierarchical linear modeling revealed an association between negative social interactions and metabolic symptom trajectories. To the extent that participants had more intense negative social encounters in daily life, they showed increasing scores on a composite indicator of metabolic risk over 2 years. This association was independent of a variety of potential confounders, and persisted when symptoms of depression and broader personality traits were controlled. There was no association between positive social encounters and metabolic risk trajectories. These findings suggest that even in otherwise healthy adolescents, abrasive social encounters may accelerate the progression of early stages of CVD.
C1 [Ross, Kharah] Univ British Columbia, Dept Psychol, Vancouver, BC V6T 1Z4, Canada.
C3 University of British Columbia
RP Ross, K (corresponding author), Univ British Columbia, Dept Psychol, 2136 West Mall, Vancouver, BC V6T 1Z4, Canada.
EM kmross@psych.ubc.ca
RI ; Ross, Kharah/M-1453-2016
OI Miller, Gregory/0000-0002-7217-1082; Ross, Kharah/0000-0002-1472-5630
CR ALDERMAN MH, 1990, J CLIN EPIDEMIOL, V43, P859, DOI 10.1016/0895-4356(90)90069-2
   Allen JP, 2006, J CONSULT CLIN PSYCH, V74, P55, DOI 10.1037/0022-006X.74.1.55
   Baker B, 2000, ARCH INTERN MED, V160, P3453, DOI 10.1001/archinte.160.22.3453
   Barth J, 2010, PSYCHOSOM MED, V72, P229, DOI 10.1097/PSY.0b013e3181d01611
   Baumeister R. F., 2001, Review of General Psychology, V5, P323, DOI [10.1037//1089-2680.5.4.323, 10.1037/1089-2680.5.4.323, DOI 10.1037/1089-2680.5.4.323]
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   BERKMAN LF, 1992, ANN INTERN MED, V117, P1003, DOI 10.7326/0003-4819-117-12-1003
   Björntorp P, 1999, ANN NY ACAD SCI, V892, P297, DOI 10.1111/j.1749-6632.1999.tb07803.x
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   Caspi A, 2006, ARCH PEDIAT ADOL MED, V160, P805, DOI 10.1001/archpedi.160.8.805
   Chen E, 2007, ANN BEHAV MED, V34, P26, DOI 10.1007/BF02879918
   Doeven-Eggens L, 2008, PERS INDIV DIFFER, V45, P689, DOI 10.1016/j.paid.2008.07.017
   Dunn AL, 2001, MED SCI SPORT EXER, V33, pS587, DOI 10.1097/00005768-200106001-00027
   Eisenmann JC, 2008, CARDIOVASC DIABETOL, V7, DOI 10.1186/1475-2840-7-17
   Ekelund U, 2005, DIABETES CARE, V28, P1195, DOI 10.2337/diacare.28.5.1195
   Eng PM, 2002, AM J EPIDEMIOL, V155, P700, DOI 10.1093/aje/155.8.700
   EWART CK, 1991, HEALTH PSYCHOL, V10, P155, DOI 10.1037/0278-6133.10.3.155
   Finch JF, 1999, J PERS, V67, P581, DOI 10.1111/1467-6494.00066
   FINCH JF, 1989, AM J COMMUN PSYCHOL, V17, P585, DOI 10.1007/BF00922637
   Frasure-Smith N, 2000, CIRCULATION, V101, P1919, DOI 10.1161/01.CIR.101.16.1919
   Gallo LC, 2006, PSYCHOSOM MED, V68, P253, DOI 10.1097/01.psy.0000204633.33599.81
   Goodman E, 2007, CIRCULATION, V115, P2316, DOI 10.1161/CIRCULATIONAHA.106.669994
   GORKIN L, 1993, AM J CARDIOL, V71, P263, DOI 10.1016/0002-9149(93)90788-E
   Graham JE, 2007, PSYCHONEUROIMMUNOLOGY, VOLS I AND II, 4TH EDITION, P781
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Heffner KL, 2004, J BEHAV MED, V27, P233, DOI 10.1023/B:JOBM.0000028497.79129.ad
   Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
   Ikeda A, 2011, J EPIDEMIOL COMMUN H, V65, P71, DOI 10.1136/jech.2009.090613
   Janicki DL, 2005, PSYCHOSOM MED, V67, P889, DOI 10.1097/01.psy.0000188476.87869.88
   Janisse HC, 2004, WOMEN HEALTH, V39, P101, DOI 10.1300/J013v39n01_06
   John O.P., 1991, BIG 5 INVENTORY VERS
   Kamarck TW, 1998, HEALTH PSYCHOL, V17, P17, DOI 10.1037/0278-6133.17.1.17
   KAMARCK TW, 1990, PSYCHOSOM MED, V52, P42, DOI 10.1097/00006842-199001000-00004
   Kamarck TW, 2002, PHYSIOL BEHAV, V77, P699, DOI 10.1016/S0031-9384(02)00921-6
   Kavey REW, 2003, CIRCULATION, V107, P1562, DOI 10.1161/01.CIR.0000061521.15730.6E
   Kawachi I, 1996, J EPIDEMIOL COMMUN H, V50, P245, DOI 10.1136/jech.50.3.245
   KEYS A, 1971, ARCH INTERN MED, V128, P201, DOI 10.1001/archinte.1971.00310200037002
   Kiecolt-Glaser JK, 2005, ARCH GEN PSYCHIAT, V62, P1377, DOI 10.1001/archpsyc.62.12.1377
   Kiecolt-Glaser JK, 2001, PSYCHOL BULL, V127, P472, DOI 10.1037//0033-2909.127.4.472
   KiecoltGlaser JK, 1996, J CONSULT CLIN PSYCH, V64, P324, DOI 10.1037/0022-006X.64.2.324
   KIECOLTGLASER JK, 1993, PSYCHOSOM MED, V55, P395, DOI 10.1097/00006842-199309000-00001
   KiecoltGlaser JK, 1997, PSYCHOSOM MED, V59, P339, DOI 10.1097/00006842-199707000-00001
   Kinder LS, 2004, PSYCHOSOM MED, V66, P316, DOI 10.1097/01.psy.0000124755.91880.f4
   Knox SS, 1998, PSYCHONEUROENDOCRINO, V23, P877, DOI 10.1016/S0306-4530(98)00061-4
   Kop WJ, 1999, PSYCHOSOM MED, V61, P476, DOI 10.1097/00006842-199907000-00012
   Krantz DS, 1999, AM J CARDIOL, V84, P1292, DOI 10.1016/S0002-9149(99)00560-3
   Kuper Hannah, 2002, Semin Vasc Med, V2, P267, DOI 10.1055/s-2002-35401
   Laaksonen DE, 2002, DIABETES CARE, V25, P1612, DOI 10.2337/diacare.25.9.1612
   Lakka TA, 2003, MED SCI SPORT EXER, V35, P1279, DOI 10.1249/01.MSS.0000079076.74931.9A
   Lee A, 2010, J CLIN CHILD ADOLESC, V39, P603, DOI 10.1080/15374416.2010.501284
   LEPORE SJ, 1993, PSYCHOSOM MED, V55, P518, DOI 10.1097/00006842-199311000-00007
   Lett HS, 2005, PSYCHOSOM MED, V67, P869, DOI 10.1097/01.psy.0000188393.73571.0a
   MANUCK SB, 1992, PSYCHOSOM MED, V54, P102, DOI 10.1097/00006842-199201000-00003
   Matthews KA, 2005, AM PSYCHOL, V60, P783, DOI 10.1037/0003-066X.60.8.783
   Mattu GS, 2004, BLOOD PRESS MONIT, V9, P47, DOI 10.1097/00126097-200402000-00009
   McGill HC, 2000, AM J CLIN NUTR, V72, p1307S, DOI 10.1093/ajcn/72.5.1307s
   Miller GE, 2009, PSYCHOSOM MED, V71, P57, DOI 10.1097/PSY.0b013e318190d7de
   Moran A, 2008, CIRCULATION, V117, P2361, DOI 10.1161/CIRCULATIONAHA.107.704569
   Morrison JA, 2007, PEDIATRICS, V120, P340, DOI 10.1542/peds.2006-1699
   Newsom JT, 2005, J GERONTOL B-PSYCHOL, V60, pP304, DOI 10.1093/geronb/60.6.P304
   NOLENHOEKSEMA S, 1999, PSYCHOL BULL, V115, P424
   PAFFENBARGER RS, 1993, MED SCI SPORT EXER, V25, P60, DOI 10.1249/00005768-199301000-00010
   Penedo FJ, 2005, CURR OPIN PSYCHIATR, V18, P189, DOI 10.1097/00001504-200503000-00013
   Raudenbush SW, 2006, HLM VERSION 6 03
   Reis H.T., 1991, Advanced in experimental social psychology, P269
   Rook K., 2001, APPL DEV SCI, V5, P86, DOI [DOI 10.1207/S1532480XADS0502_4, 10.1207/S1532480XADS05024, DOI 10.1207/S1532480XADS05024]
   Rugulies R, 2002, AM J PREV MED, V23, P51, DOI 10.1016/S0749-3797(02)00439-7
   SCARR S, 1983, CHILD DEV, V54, P424, DOI 10.1111/j.1467-8624.1983.tb03884.x
   Schrepferman LM, 2006, J EMOT BEHAV DISORD, V14, P50, DOI 10.1177/10634266060140010501
   SCHUSTER TL, 1990, AM J COMMUN PSYCHOL, V18, P423, DOI 10.1007/BF00938116
   Scully D, 1998, BRIT J SPORT MED, V32, P111, DOI 10.1136/bjsm.32.2.111
   SEEMAN TE, 1987, PSYCHOSOM MED, V49, P341, DOI 10.1097/00006842-198707000-00003
   Sheps DS, 2002, CIRCULATION, V105, P1780, DOI 10.1161/01.CIR.0000014491.90666.06
   Shipley BA, 2007, PSYCHOSOM MED, V69, P923, DOI 10.1097/PSY.0b013e31815abf83
   Smith TW, 2006, ANNU REV CLIN PSYCHO, V2, P435, DOI 10.1146/annurev.clinpsy.2.022305.095257
   Smith TW, 2009, PSYCHOL AGING, V24, P274, DOI 10.1037/a0016067
   Strong JP, 1999, JAMA-J AM MED ASSOC, V281, P727, DOI 10.1001/jama.281.8.727
   Swickert RJ, 2010, PERS INDIV DIFFER, V48, P736, DOI 10.1016/j.paid.2010.01.018
   Terracciano A, 2008, PSYCHOSOM MED, V70, P621, DOI 10.1097/PSY.0b013e31817b9371
   Treiber FA, 2003, PSYCHOSOM MED, V65, P46, DOI 10.1097/00006842-200301000-00007
   Troxel WM, 2005, ARCH INTERN MED, V165, P1022, DOI 10.1001/archinte.165.9.1022
   Uchino BN, 2011, BIOL PSYCHOL, V86, P137, DOI 10.1016/j.biopsycho.2010.04.003
   VOGT TM, 1992, J CLIN EPIDEMIOL, V45, P659, DOI 10.1016/0895-4356(92)90138-D
   Wysocki T, 2007, DIABETES CARE, V30, P555, DOI 10.2337/dc06-1613
NR 84
TC 24
Z9 32
U1 0
U2 11
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0954-5794
EI 1469-2198
J9 DEV PSYCHOPATHOL
JI Dev. Psychopathol.
PD AUG
PY 2011
VL 23
IS 3
SI SI
BP 897
EP 906
DI 10.1017/S0954579411000381
PG 10
WC Psychology, Developmental
WE Social Science Citation Index (SSCI)
SC Psychology
GA 801OY
UT WOS:000293451100012
PM 21756440
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Waldman, ZC
   Schenk, BR
   Karera, MGD
   Patterson, AC
   Hormenu, T
   Mabundo, LS
   DuBose, CW
   Jagannathan, R
   Whitesell, PL
   Wentzel, A
   Horlyck-Romanovsky, MF
   Sumner, AE
AF Waldman, Zoe C.
   Schenk, Blayne R.
   Duhuze Karera, Marie Grace
   Patterson, Arielle C.
   Hormenu, Thomas
   Mabundo, Lilian S.
   DuBose, Christopher W.
   Jagannathan, Ram
   Whitesell, Peter L.
   Wentzel, Annemarie
   Horlyck-Romanovsky, Margrethe F.
   Sumner, Anne E.
TI Sleep and Economic Status Are Linked to Daily Life Stress in
   African-Born Blacks Living in America
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE African immigrants; perceived stress; sleep quality; socioeconomic
   status
ID CARDIOMETABOLIC HEALTH; CARDIOVASCULAR HEALTH; METABOLIC SYNDROME;
   GLUCOSE-TOLERANCE; RISK-FACTORS; IMMIGRANTS; DURATION; QUALITY;
   ASSOCIATION; HEMOGLOBIN
AB To identify determinants of daily life stress in Africans in America, 156 African-born Blacks (Age: 40 +/- 10 years (mean +/- SD), range 22-65 years) who came to the United States as adults (age >= 18 years) were asked about stress, sleep, behavior and socioeconomic status. Daily life stress and sleep quality were assessed with the Perceived Stress Scale (PSS) and Pittsburgh Sleep Quality Index (PSQI), respectively. High-stress was defined by the threshold of the upper quartile of population distribution of PSS (>= 16) and low-stress as PSS < 16. Poor sleep quality required PSQI > 5. Low income was defined as <40 k yearly. In the high and low-stress groups, PSS were: 21 +/- 4 versus 9 +/- 4, p < 0.001 and PSQI were: 6 +/- 3 versus 4 +/- 3, p < 0.001, respectively. PSS and PSQI were correlated (r = 0.38, p < 0.001). The odds of high-stress were higher among those with poor sleep quality (OR 5.11, 95% CI: 2.07, 12.62), low income (OR 5.03, 95% CI: 1.75, 14.47), and no health insurance (OR 3.01, 95% CI: 1.19, 8.56). Overall, in African-born Blacks living in America, daily life stress appears to be linked to poor quality sleep and exacerbated by low income and lack of health insurance.
C1 [Waldman, Zoe C.; Schenk, Blayne R.; Duhuze Karera, Marie Grace; Patterson, Arielle C.; Hormenu, Thomas; Mabundo, Lilian S.; DuBose, Christopher W.; Wentzel, Annemarie; Horlyck-Romanovsky, Margrethe F.; Sumner, Anne E.] NIDDKD, Sect Ethn & Hlth, Diabet Endocrinol & Obes Branch, Bethesda, MD USA.
   [Duhuze Karera, Marie Grace; Sumner, Anne E.] Natl Inst Minor Hlth & Hlth Dispar, Bethesda, MD USA.
   [Duhuze Karera, Marie Grace] Univ Global Hlth Equ, Inst Global Hlth Equ Res, Kigali, Rwanda.
   [Hormenu, Thomas] Univ Cape Coast, Dept Hlth, Phys Educ, POB 5007, Cape Coast, Ghana.
   [Jagannathan, Ram] Emory Univ, Sch Med, Dept Med, Atlanta, GA USA.
   [Whitesell, Peter L.] Howard Univ, Howard Univ Hosp, Sleep Disorders Ctr, 2041 Georgia Ave NW, Washington, DC USA.
   [Horlyck-Romanovsky, Margrethe F.] City Univ New York, Brooklyn Coll, Dept Hlth & Nutr Sci, New York, NY USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Diabetes & Digestive & Kidney Diseases (NIDDK); National Institutes of
   Health (NIH) - USA; NIH National Institute on Minority Health & Health
   Disparities (NIMHD); University of Cape Coast; Emory University; Howard
   University; City University of New York (CUNY) System; Brooklyn College
   (CUNY)
RP Sumner, AE (corresponding author), NIDDKD, Sect Ethn & Hlth, Diabet Endocrinol & Obes Branch, Bethesda, MD USA.; Sumner, AE (corresponding author), Natl Inst Minor Hlth & Hlth Dispar, Bethesda, MD USA.
EM blayne.schenk@nih.gov; gduhuze@ughe.org; arielle.patterson@nih.gov;
   thormenu@ucc.edu.gh; lilian.mabundo@nih.gov; christopher.dubose@nih.gov;
   thormenu@ucc.edu.gh; ram.jagannathan@emory.edu;
   peter.whitesell@howard.edu; annemarie.wentzel@nih.gov;
   margrethehr@brooklyn.cuny.edu; zoe.waldman@nih.gov
RI Hormenu, Thomas/JBJ-0389-2023; Jagannathan, Ram/J-1149-2019; Wentzel,
   Annemarie/IUO-0720-2023; Horlyck-Romanovsky, Margrethe/AAZ-4740-2020
OI Whitesell, Peter/0000-0002-3654-6203; Schenk,
   Blayne/0000-0002-9990-424X; Waldman, Zoe/0000-0002-7016-4065; Hormenu,
   Thomas/0000-0002-9416-4406; Sumner, Anne/0000-0001-9640-8999; Duhuze
   Karera, Grace/0000-0002-0815-3576
FU NIDDK; NIMHD
FX Funding came from the Intramural Programs of NIDDK and NIMHD.
CR Afrifa-Anane E, 2020, MED SCI SPORT EXER, V52, P2152, DOI 10.1249/MSS.0000000000002357
   Afulani PA, 2016, SOC SCI MED, V168, P63, DOI 10.1016/j.socscimed.2016.09.009
   Anderson M., FACTS BLACK IMMIGRAN
   Anderson M., 2017, AFRICAN IMMIGRANT PO
   [Anonymous], 2017, UNC HLTH CAR
   [Anonymous], 2005, The International Physical Activity Questionnaire
   Atas DB, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0248117
   Baratin C, 2020, SOC PSYCH PSYCH EPID, V55, P45, DOI 10.1007/s00127-019-01682-1
   Bidulescu A, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-581
   Briker SM, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00533
   BUYSSE DJ, 1989, PSYCHIAT RES, V28, P193, DOI 10.1016/0165-1781(89)90047-4
   Carnethon MR, 2017, CIRCULATION, V136, pE393, DOI 10.1161/CIR.0000000000000534
   Chilunga FP, 2019, J GLOB HEALTH, V9, DOI 10.7189/jogh.09.020426
   Chilunga FP, 2019, INT J CARDIOL, V286, P169, DOI 10.1016/j.ijcard.2018.12.056
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   COHEN S, 1988, CLAR SYMP, P31
   Cole HV, 2017, SLEEP MED, V34, P118, DOI 10.1016/j.sleep.2017.03.008
   Commodore-Mensah Y, 2018, J IMMIGR MINOR HEALT, V20, P1137, DOI 10.1007/s10903-017-0644-y
   Commodore-Mensah Y, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.116.004059
   Commodore-Mensah Y, 2015, ETHNIC DIS, V25, P373, DOI 10.18865/ed.25.3.373
   Connor KM, 2003, DEPRESS ANXIETY, V18, P76, DOI 10.1002/da.10113
   Creatore MI, 2010, CAN MED ASSOC J, V182, P781, DOI 10.1503/cmaj.091551
   Esheverria-Estrada C., 2019, Sub-Saharan African Immigrants in the United States
   Ezzati A, 2014, INT J GERIATR PSYCH, V29, P645, DOI 10.1002/gps.4049
   Ferrari U, 2015, J PSYCHIATR RES, V65, P166, DOI 10.1016/j.jpsychires.2015.02.012
   Gangwisch JE, 2007, SLEEP, V30, P1667, DOI 10.1093/sleep/30.12.1667
   Geronimus AT, 2006, AM J PUBLIC HEALTH, V96, P826, DOI 10.2105/AJPH.2004.060749
   Guthold R, 2018, LANCET GLOB HEALTH, V6, pE1077, DOI [10.1016/S2214-109X(18)30357-7, 10.1016/s2214-109x(18)30357-7]
   Hall MH, 2008, SLEEP, V31, P635, DOI 10.1093/sleep/31.5.635
   Harris PA, 2009, J BIOMED INFORM, V42, P377, DOI 10.1016/j.jbi.2008.08.010
   Hayfron-Benjamin CF, 2020, BMJ OPEN DIAB RES CA, V8, DOI 10.1136/bmjdrc-2020-001235
   Hobabagabo AF, 2020, DIABETES CARE, V43, P2607, DOI 10.2337/dc20-1119
   Hormenu T, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17124533
   Ishimwe MCS, 2021, BMJ OPEN DIAB RES CA, V9, DOI 10.1136/bmjdrc-2021-002447
   Jagannathan R, 2020, DIABETES RES CLIN PR, V170, DOI 10.1016/j.diabres.2020.108523
   Jiang F, 2014, DRUG ALCOHOL DEPEN, V145, P69, DOI 10.1016/j.drugalcdep.2014.10.022
   Kengne AP, 2017, INT J EPIDEMIOL, V46, P1421, DOI 10.1093/ije/dyx078
   McEwen BS, 1998, NEW ENGL J MED, V338, P171, DOI 10.1056/NEJM199801153380307
   Mukaz DK, 2022, ETHNIC HEALTH, V27, P770, DOI 10.1080/13557858.2020.1820958
   O'Connor MY, 2014, METAB SYNDR RELAT D, V12, P347, DOI 10.1089/met.2014.0026
   Ounpuu S, 2001, AM HEART J, V141, P711, DOI 10.1067/mhj.2001.114974
   Pesko MF, 2016, ECON HUM BIOL, V22, P94, DOI 10.1016/j.ehb.2016.03.007
   Piel FB, 2013, SCI REP-UK, V3, DOI 10.1038/srep01671
   Piel FB, 2013, LANCET, V381, P142, DOI 10.1016/S0140-6736(12)61229-X
   Rosengren A, 2004, LANCET, V364, P953, DOI 10.1016/S0140-6736(04)17019-0
   Shoup EM, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17249405
   Thomas SC, 2019, J RACIAL ETHN HEALTH, V6, P487, DOI 10.1007/s40615-018-00547-8
   Turkson-Ocran RAN, 2020, ETHNIC DIS, V30, P651, DOI 10.18865/ed.30.4.651
   Ukegbu UJ, 2011, DIABETES CARE, V34, P2297, DOI 10.2337/dc11-1055
   Utumatwishima JN, 2018, J RACIAL ETHN HEALTH, V5, P279, DOI 10.1007/s40615-017-0368-7
   Utumatwishima JN, 2018, NAT REV ENDOCRINOL, V14, P45, DOI 10.1038/nrendo.2017.127
   Van Laethem M, 2015, J PSYCHOSOM RES, V79, P391, DOI 10.1016/j.jpsychores.2015.08.011
   Williams D R, 1997, J Health Psychol, V2, P335, DOI 10.1177/135910539700200305
   Zhao XL, 2021, SLEEP MED, V77, P339, DOI 10.1016/j.sleep.2020.05.021
NR 54
TC 4
Z9 4
U1 0
U2 5
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD MAR
PY 2022
VL 19
IS 5
AR 2562
DI 10.3390/ijerph19052562
PG 14
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA ZY8MD
UT WOS:000772834100001
PM 35270258
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Akki, R
   Raghay, K
   Errami, M
AF Akki, Rachid
   Raghay, Kawtar
   Errami, Mohammed
TI Potentiality of ghrelin as antioxidant and protective agent
SO REDOX REPORT
LA English
DT Review
DE Ghrelin; antioxidant; oxidative stress; systemic oxidative stress sensor
ID INDUCED OXIDATIVE STRESS; STEM-CELL FACTOR; ACUTE-PANCREATITIS;
   METABOLIC SYNDROME; ACYLATED GHRELIN; PLASMA GHRELIN; LIVER-INJURY;
   APOPTOSIS; OBESITY; SYSTEM
AB Background
   Oxidative stress is the result of cellular troubles related to aerobic metabolism. Furthermore, this stress is always associated with biological responses evoked by physical, chemical, environmental, and psychological factors. Several studies have developed many approaches of antioxidant defense to diminish the severity of many diseases. Ghrelin was originally identified from the rat stomach, and it is a potent growth hormone-releasing peptide that has pleiotropic functions.
   Methods
   A systematic review was conducted within PubMed, ScienceDirect, MEDLINE, and Scopus databases using keywords such as ghrelin, antioxidant, oxidative stress, and systemic oxidative stress sensor.
   Results
   In the last decade, many studies show that ghrelin exhibits protection effects against oxidative stress derived probably from its antioxidant effects. Pieces of evidence demonstrate that systemic oxidative stress increase ghrelin levels in the plasma. The expression of ghrelin and its receptor in ghrelin peripheral tissues and extensively in the central nervous system suggests that this endogenous peptide plays an important role as a systemic oxidative stress sensor
   Conclusion
   The current evidence confirms that ghrelin and its derived peptides (Desacyl-ghrelin, obestatin) act as a protective antioxidant agent. Therefore, stressor modality, duration, and intensity are the parameters of oxidative stress that must be taken into consideration to determine the role of ghrelin, Desacyl-ghrelin, and obestatin in the regulation of cell death pathways.
C1 [Akki, Rachid] Natl Sch Agr Meknes ENA, Dept Plant Protect & Environm, Meknes, Morocco.
   [Akki, Rachid; Raghay, Kawtar; Errami, Mohammed] Abdelmalek Essaadi Univ, Fac Sci, Dept Biol, Tetouan, Morocco.
C3 Moulay Ismail University of Meknes; Abdelmalek Essaadi University of
   Tetouan
RP Akki, R (corresponding author), Natl Sch Agr Meknes ENA, Dept Plant Protect & Environm, Meknes, Morocco.; Akki, R (corresponding author), Abdelmalek Essaadi Univ, Fac Sci, Dept Biol, Tetouan, Morocco.
EM akki.rachid2011@gmail.com
RI ; Raghay, Kawtar/AAO-9015-2020
OI AKKI, RACHID/0000-0001-7653-5480; Raghay, Kawtar/0000-0003-2695-2635
CR Ahsan H, 2013, HUM IMMUNOL, V74, P1392, DOI 10.1016/j.humimm.2013.06.009
   Akalu Y, 2020, INT J ENDOCRINOL, V2020, DOI 10.1155/2020/1385138
   Akamizu T, 2004, EUR J ENDOCRINOL, V150, P447, DOI 10.1530/eje.0.1500447
   Akki R, 2022, ARCH PHYSIOL BIOCHEM, V128, P521, DOI 10.1080/13813455.2019.1702059
   Akki R, 2018, CELL BIOCHEM FUNCT, V36, P56, DOI 10.1002/cbf.3317
   Alhashem F, 2014, EXCLI J, V13, P551
   Alirezaei M, 2015, INT J PEPT RES THER, V21, P411, DOI 10.1007/s10989-015-9470-z
   Altabas V, 2015, IMMUNOTARGETS THER, V4, P123, DOI 10.2147/ITT.S60398
   Amitani M, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18071511
   Andrews ZB, 2011, TRENDS NEUROSCI, V34, P31, DOI 10.1016/j.tins.2010.10.001
   Angelova PR, 2018, FEBS LETT, V592, P692, DOI 10.1002/1873-3468.12964
   [Anonymous], 2014, J PHYSL PATHOPHYSIOL, DOI [10.5897/JPAP2014.0091, DOI 10.5897/JPAP2014.0091]
   Barazzoni R, 2014, OBESITY, V22, P170, DOI 10.1002/oby.20454
   Barreiro ML, 2004, ENDOCRINOLOGY, V145, P4825, DOI 10.1210/en.2004-0732
   Bianchi E, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0177995
   Bochicchio G, 2012, WORLD J SURG, V36, P39, DOI 10.1007/s00268-011-1335-9
   Bonior J, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18071402
   Boshra Vivian, 2017, Journal of Basic and Clinical Physiology and Pharmacology, V28, P347, DOI 10.1515/jbcpp-2016-0145
   Can N, 2015, DRUG DES DEV THER, V9, P2819, DOI 10.2147/DDDT.S83067
   Carniglia L, 2017, MEDIAT INFLAMM, V2017, DOI 10.1155/2017/5048616
   Cencioni C, 2013, INT J MOL SCI, V14, P17643, DOI 10.3390/ijms140917643
   Çetin E, 2011, REGUL PEPTIDES, V171, P1, DOI 10.1016/j.regpep.2011.05.010
   Coyoy-Salgado A, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/3642491
   Date Y, 2000, ENDOCRINOLOGY, V141, P4255, DOI 10.1210/en.141.11.4255
   Date Y, 2012, METHOD ENZYMOL, V514, P261, DOI 10.1016/B978-0-12-381272-8.00016-7
   Ramirez ND, 2019, HELIYON, V5, DOI 10.1016/j.heliyon.2019.e02886
   Delporte C, 2013, SCIENTIFICA, V2013, DOI 10.1155/2013/518909
   Dembinski A, 2003, J PHYSIOL PHARMACOL, V54, P561
   Dobutovic B, 2014, ARCH MED SCI, V10, P806, DOI 10.5114/aoms.2014.44872
   Dong MH, 2006, CURR OPIN GASTROEN, V22, P599, DOI 10.1097/01.mog.0000245540.87784.75
   Ejskjaer N, 2009, ALIMENT PHARM THER, V29, P1179, DOI 10.1111/j.1365-2036.2009.03986.x
   Elias RJ, 2008, CRIT REV FOOD SCI, V48, P430, DOI 10.1080/10408390701425615
   Elsawy M, 2016, Tanta Med J, V44, P163
   Ercan S, 2013, FOOD CHEM TOXICOL, V56, P154, DOI 10.1016/j.fct.2013.02.019
   Faienza MF, 2012, HORM RES PAEDIAT, V78, P158, DOI 10.1159/000342642
   Farzaei MH, 2018, FOOD CHEM TOXICOL, V120, P183, DOI 10.1016/j.fct.2018.07.010
   Fujimura K, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094373
   Ge TT, 2017, ONCOTARGET, V8, P59929, DOI 10.18632/oncotarget.18349
   Gholami M, 2017, INT J REPROD BIOMED, V15, P265
   Gnanapavan S, 2002, J CLIN ENDOCR METAB, V87, P2988, DOI 10.1210/jc.87.6.2988
   Goldstein BJ, 2005, ANTIOXID REDOX SIGN, V7, P1021, DOI 10.1089/ars.2005.7.1021
   Hikim APS, 2003, J STEROID BIOCHEM, V85, P175, DOI 10.1016/S0960-0760(03)00193-6
   Hikim APS, 2003, ENDOCRINOLOGY, V144, P3167, DOI 10.1210/en.2003-0175
   Hosseini L, 2020, J CARDIOVASC PHARM T, V25, P240, DOI 10.1177/1074248419882002
   Jaworek J, 2014, WORLD J GASTROENTERO, V20, P16902, DOI 10.3748/wjg.v20.i45.16902
   Jensen TK, 2004, FERTIL STERIL, V82, P863, DOI 10.1016/j.fertnstert.2004.03.056
   Jiang TF, 2016, PROG NEUROBIOL, V147, P1, DOI 10.1016/j.pneurobio.2016.07.005
   Kabil NN, 2014, PEPTIDES, V52, P90, DOI 10.1016/j.peptides.2013.11.022
   Kheradmand A, 2009, ANDROLOGIA, V41, P335, DOI 10.1111/j.1439-0272.2009.00932.x
   Kheradmand A, 2012, TISSUE CELL, V44, P308, DOI 10.1016/j.tice.2012.04.009
   Kojima M, 1999, NATURE, V402, P656, DOI 10.1038/45230
   Kojima M, 2016, J BIOCHEM, V160, P189, DOI 10.1093/jb/mvw046
   Koyuturk M, 2015, CELL BIOL INT, V39, P834, DOI 10.1002/cbin.10464
   Ku JM, 2015, ENDOCRINOLOGY, V156, P280, DOI 10.1210/en.2014-1415
   Lee JY, 2011, ENDOCRINOLOGY, V152, P2377, DOI 10.1210/en.2011-0090
   Li Y, 2013, ENDOCRINE, V43, P376, DOI 10.1007/s12020-012-9761-5
   Liu SW, 2018, NEUROPEPTIDES, V67, P63, DOI 10.1016/j.npep.2017.11.007
   Liu Yajun, 2009, BMC Physiology, V9, P17, DOI 10.1186/1472-6793-9-17
   Lyra HF, 2019, J SURG RES, V234, P167, DOI 10.1016/j.jss.2018.09.045
   Magnusdottir EV, 2005, HUM REPROD, V20, P208, DOI 10.1093/humrep/deh569
   Mani BK, 2020, AM J PHYSIOL-ENDOC M, V319, pE330, DOI 10.1152/ajpendo.00119.2020
   Markesbery WR, 1997, FREE RADICAL BIO MED, V23, P134, DOI 10.1016/S0891-5849(96)00629-6
   Matsuki S, 2003, BIOCHEM BIOPH RES CO, V312, P843, DOI 10.1016/j.bbrc.2003.10.191
   Micheli L, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/7261842
   Neamati S., 2013, INT J PHARM TEACH PR, V4, P451
   Neamati S, 2011, INT J PEPT RES THER, V17, P239, DOI 10.1007/s10989-011-9263-y
   Nyska A, 2002, TOXICOL PATHOL, V30, P620, DOI 10.1080/01926230290166724
   Obay BD, 2008, PEPTIDES, V29, P448, DOI 10.1016/j.peptides.2007.11.020
   Obay BD, 2007, PEPTIDES, V28, P1214, DOI 10.1016/j.peptides.2007.04.003
   Omrani H, 2015, ADV PHARM BULL, V5, P283, DOI 10.15171/apb.2015.039
   Packer L, 2007, FREE RADICAL RES, V41, P951, DOI 10.1080/10715760701490975
   Perry B, 2012, NUTR DIABETES, V2, DOI 10.1038/nutd.2011.21
   Pinazo-Durán MD, 2018, CURR NEUROPHARMACOL, V16, P903, DOI 10.2174/1570159X15666170705101910
   Portelli J, 2015, NEUROPEPTIDES, V51, P1, DOI 10.1016/j.npep.2015.04.004
   Quiñones M, 2020, REV ENDOCR METAB DIS, V21, P45, DOI 10.1007/s11154-019-09528-6
   Raghay K, 2020, PEPTIDES, V124, DOI 10.1016/j.peptides.2019.170226
   Razzaghy-Azar M, 2016, J CLIN MED, V5, DOI 10.3390/jcm5070061
   Rocha-Sousa A, 2006, EXP EYE RES, V83, P1179, DOI 10.1016/j.exer.2006.06.005
   Rocha-Sousa A, 2014, PEPTIDES, V57, P59, DOI 10.1016/j.peptides.2014.04.013
   Sachdev S, 2008, FREE RADICAL BIO MED, V44, P215, DOI 10.1016/j.freeradbiomed.2007.07.019
   Sallmén M, 2006, EPIDEMIOLOGY, V17, P520, DOI 10.1097/01.ede.0000229953.76862.e5
   Satou M, 2011, PEPTIDES, V32, P2183, DOI 10.1016/j.peptides.2011.06.029
   Sever S, 2016, ENDOCR-RELAT CANCER, V23, pR393, DOI 10.1530/ERC-16-0130
   Seyhanli ES, 2015, INT J CLIN EXP MED, V8, P722
   Shimada T, 2014, METABOLISM, V63, P469, DOI 10.1016/j.metabol.2013.12.011
   Sibilia V, 2008, BRIT J PHARMACOL, V154, P688, DOI 10.1038/bjp.2008.120
   Siracusa R, 2015, CNS NEUROL DISORD-DR, V14, P1350, DOI 10.2174/1871527314666150821102823
   Song N, 2017, MOVEMENT DISORD, V32, P1487, DOI 10.1002/mds.27095
   Spencer SJ, 2013, BRAIN SCI, V3, P344, DOI 10.3390/brainsci3010344
   St-Louis R, 2014, FREE RADICAL BIO MED, V71, P231, DOI 10.1016/j.freeradbiomed.2014.03.024
   Stempniewicz A, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20071534
   Stenholm S, 2011, AGING CLIN EXP RES, V23, P153, DOI 10.1007/BF03351078
   Subbarao KC, 2019, J PHARM BIOALLIED SC, V11, pS135, DOI [10.4103/JPBS.JPBS_56_19, 10.4103/jpbs.JPBS_56_19]
   Sukumaran V, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00196
   Suzuki H, 2011, J CLIN BIOCHEM NUTR, V48, P122, DOI 10.3164/jcbn.10-16GFR
   Takeda R, 2006, J AM SOC NEPHROL, V17, P113, DOI 10.1681/ASN.2004080626
   Tena-Sempere M, 2002, ENDOCRINOLOGY, V143, P717, DOI 10.1210/en.143.2.717
   Venkatesh S, 2019, J MOL CELL CARDIOL, V128, P38, DOI 10.1016/j.yjmcc.2018.12.017
   Wang X, 2016, MOL BIOL REP, V43, P607, DOI 10.1007/s11033-016-4022-y
   Whirledge SD, 2015, BIOL REPROD, V92, DOI 10.1095/biolreprod.114.123570
   Yu RL, 2018, EBIOMEDICINE, V36, P304, DOI 10.1016/j.ebiom.2018.09.027
   Zanetti M, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20030499
   Zaniolo K, 2011, INVEST OPHTH VIS SCI, V52, P5376, DOI 10.1167/iovs.10-7152
   Zhang SR, 2015, WORLD J GASTROENTERO, V21, P3214, DOI 10.3748/wjg.v21.i11.3214
   Zhu K, 2017, INVEST OPHTH VIS SCI, V58, P6113, DOI 10.1167/iovs.17-22465
NR 105
TC 16
Z9 16
U1 2
U2 14
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1351-0002
EI 1743-2928
J9 REDOX REP
JI Redox Rep.
PD JAN 1
PY 2021
VL 26
IS 1
BP 71
EP 79
DI 10.1080/13510002.2021.1913374
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA RN0BU
UT WOS:000640021800001
PM 33849404
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Burgess, APH
   Vanella, L
   Bellner, L
   Gotlinger, K
   Falck, JR
   Abraham, NG
   Schwartzman, ML
   Kappas, A
AF Burgess, Angela P. H.
   Vanella, Luca
   Bellner, Lars
   Gotlinger, Katherine
   Falck, John R.
   Abraham, Nader G.
   Schwartzman, Michal L.
   Kappas, Attallah
TI Heme Oxygenase (HO-1) Rescue of Adipocyte Dysfunction in HO-2 Deficient
   Mice via Recruitment of Epoxyeicosatrienoic Acids (EETs) and Adiponectin
SO CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE HO; Stress response genes; Antioxidants; Cardiovascular; Diabetes;
   Carbon monoxide; Bilirubin
ID NECROSIS-FACTOR-ALPHA; OXIDATIVE STRESS; EPOXIDE HYDROLASE;
   11,12-EPOXYEICOSATRIENOIC ACID; INSULIN SENSITIVITY; THERAPEUTIC
   TARGETS; EXPRESSION; EPOXYGENASE; INDUCTION; INCREASES
AB Background/Aims: HO-1 and EETs are functionally linked and their interactions influence body weight, insulin sensitivity, and serum levels of inflammatory cytokines in metabolic syndrome phenotype of HO-2 null mice. The HO-2 isozyme is essential for regulating physiological levels of ROS. Recent studies have suggested a potential role of EET in modifying adipocyte differentiation through up-regulation of HO-1-adiponectin-AkT signaling in human mesenchymal stem cells (MSCs). Our aim was to examine the consequences of HO deficiency on MSC-derived adipogenesis in vitro using MSC derived from HO-2 null and WT mice in vivo. Methods: Four-month-old HO-2 null (HO-2(-/-)) and B6/129SF2/J (WT) mice were divided into three groups (four mice/group): WT, HO2(-/-), and HO-2(-/-) + CoPP. Adipogenesis was performed on purified MSC-derived adipocytes cultured in adipogenic differentiation media and an EET-agonist was added every 3 days. Results: HO-2 depletion of MSC adipocytes resulted in increased adipogenesis (p<0.01) and increased levels of inflammatory cytokines including (TNF)-alpha (p<0.05), (MCP)-1 (p<0.05), and (IL-1)-beta (p<0.05). These results were accompanied by decreases in HO-1 (p<0.05) and subsequently EET and HO activity (p<0.05). Upregulation of HO-1 resulted in decreased MSC-derived adipocyte differentiation, decreased production of TNF-alpha and MCP-1 and increased levels of adiponectin (p<0.05). Cyp2J5 (p<0.05), HO-1 (p<0.05), and adiponectin mRNA levels (p<0.05) were also decreased in visceral adipose tissue isolated from HO-2 null compared to WT mice. EET agonist stimulation of MSC adipocytes derived from HO-2 null mice yielded similar results. Conclusion: Increased levels of EET and HO-1 are essential for protection against the adverse effects of adipocyte hypertrophy and the ensuing metabolic syndrome. These results offer a portal into therapeutic approaches for the prevention of the metabolic syndrome. Copyright (C) 2012 S. Karger AG, Basel
C1 [Kappas, Attallah] Rockefeller Univ Hosp, New York, NY 10021 USA.
   [Burgess, Angela P. H.; Vanella, Luca; Abraham, Nader G.] Univ Toledo, Dept Physiol & Pharmacol, Toledo, OH 43606 USA.
   [Bellner, Lars; Gotlinger, Katherine; Schwartzman, Michal L.] New York Med Coll, Dept Pharmacol, Valhalla, NY 10595 USA.
   [Falck, John R.] Univ Texas SW Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA.
C3 Rockefeller University; University System of Ohio; University of Toledo;
   New York Medical College; University of Texas System; University of
   Texas Southwestern Medical Center Dallas
RP Kappas, A (corresponding author), Rockefeller Univ Hosp, 1230 York Ave, New York, NY 10021 USA.
EM michal_schwartzman@nymc.edu; kappas@rockefeller.edu
RI Falck, John/B-3030-2011; Vanella, Luca/J-7354-2016
OI Falck, John/0000-0002-9219-7845; Vanella, Luca/0000-0002-6314-6029
FU NIH [DK068134, HL55601, HL34300]; Beatrice Renfield Foundation
FX This work was supported by NIH grants DK068134, HL55601 (NGA), HL34300
   (MLS), and The Beatrice Renfield Foundation (AK).
CR Abraham NG, 2008, PHARMACOL REV, V60, P79, DOI 10.1124/pr.107.07104
   Abraham NG, 2006, CIRC RES, V99, P911, DOI 10.1161/01.RES.0000249616.10603.d6
   Abraham NG, 2005, FREE RADICAL BIO MED, V39, P1, DOI 10.1016/j.freeradbiomed.2005.03.010
   Armani A, 2010, J CELL BIOCHEM, V110, P564, DOI 10.1002/jcb.22598
   BAYNES JW, 1991, DIABETES, V40, P405, DOI 10.2337/diabetes.40.4.405
   Blühre M, 2009, EXP CLIN ENDOCR DIAB, V117, P241, DOI 10.1055/s-0029-1192044
   Brydun A, 2007, HYPERTENS RES, V30, P341, DOI 10.1291/hypres.30.341
   Burgess A, 2010, HYPERTENSION, V56, P1124, DOI 10.1161/HYPERTENSIONAHA.110.151423
   Bustin SA, 2000, J MOL ENDOCRINOL, V25, P169, DOI 10.1677/jme.0.0250169
   Crossno JT, 2006, J CLIN INVEST, V116, P3220, DOI 10.1172/JCI28510
   Dennery PA, 1998, J CLIN INVEST, V101, P1001, DOI 10.1172/JCI448
   Deshane J, 2005, ACTA BIOCHIM POL, V52, P273
   Farhangkhoee H, 2003, J MOL CELL CARDIOL, V35, P1439, DOI 10.1016/j.yjmcc.2003.09.007
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   George EM, 2011, HYPERTENSION, V57, P941, DOI 10.1161/HYPERTENSIONAHA.111.169755
   Ghattas MH, 2002, INT J BIOCHEM CELL B, V34, P1619, DOI 10.1016/S1357-2725(02)00097-3
   Goodman AI, 2006, J AM SOC NEPHROL, V17, P1073, DOI 10.1681/ASN.2004121082
   Gustafson B, 2010, J ATHEROSCLER THROMB, V17, P332, DOI 10.5551/jat.3939
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Imig JD, 2005, AM J PHYSIOL-RENAL, V289, pF496, DOI 10.1152/ajprenal.00350.2004
   Iwaki M, 2003, DIABETES, V52, P1655, DOI 10.2337/diabetes.52.7.1655
   KAPPAS A, 1995, PEDIATRICS, V95, P468
   Kim DH, 2008, J PHARMACOL EXP THER, V325, P833, DOI 10.1124/jpet.107.135285
   Kim DH, 2010, STEM CELLS DEV, V19, P1863, DOI 10.1089/scd.2010.0098
   Kim JY, 2007, J CLIN INVEST, V117, P2621, DOI 10.1172/JCI31021
   Larsen BT, 2008, CIRC RES, V102, P59, DOI 10.1161/CIRCRESAHA.107.159129
   Li M, 2008, DIABETES, V57, P1526, DOI 10.2337/db07-1764
   Münzel T, 2010, EUR HEART J, V31, P2741, DOI 10.1093/eurheartj/ehq396
   Nakatani Y, 2005, J BIOL CHEM, V280, P847, DOI 10.1074/jbc.M411860200
   Node K, 1999, SCIENCE, V285, P1276, DOI 10.1126/science.285.5431.1276
   Norwood S, 2010, AM J TRANSL RES, V2, P447
   Peterson SJ, 2009, J LIPID RES, V50, P1293, DOI 10.1194/jlr.M800610-JLR200
   POSS KD, 1995, NEURON, V15, P867, DOI 10.1016/0896-6273(95)90177-9
   Ryter SW, 2006, PHYSIOL REV, V86, P583, DOI 10.1152/physrev.00011.2005
   Sacerdoti D, 2007, PROSTAG OTH LIPID M, V82, P155, DOI 10.1016/j.prostaglandins.2006.07.001
   Sacerdoti D, 2006, AM J PHYSIOL-HEART C, V291, pH1999, DOI 10.1152/ajpheart.00082.2006
   Schenk S, 2008, J CLIN INVEST, V118, P2992, DOI 10.1172/JCI34260
   SCHERER PE, 1995, J BIOL CHEM, V270, P26746, DOI 10.1074/jbc.270.45.26746
   Sodhi K, 2009, J PHARMACOL EXP THER, V331, P906, DOI 10.1124/jpet.109.157545
   Spector AA, 2007, AM J PHYSIOL-CELL PH, V292, pC996, DOI 10.1152/ajpcell.00402.2006
   Turkseven S, 2007, J CELL BIOCHEM, V100, P815, DOI 10.1002/jcb.21138
   Vanella L, 2011, PROSTAG OTH LIPID M, V96, P54, DOI 10.1016/j.prostaglandins.2011.07.005
   Vanella L, 2010, BONE, V46, P236, DOI 10.1016/j.bone.2009.10.012
   Vera T, 2008, HYPERTENSION, V52, P660, DOI 10.1161/HYPERTENSIONAHA.108.114884
   Zhao XY, 2005, AM J PHYSIOL-REG I, V288, pR188, DOI 10.1152/ajpregu.00018.2004
NR 45
TC 39
Z9 41
U1 0
U2 3
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1015-8987
EI 1421-9778
J9 CELL PHYSIOL BIOCHEM
JI Cell. Physiol. Biochem.
PY 2012
VL 29
IS 1-2
BP 99
EP 110
DI 10.1159/000337591
PG 12
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA 903SQ
UT WOS:000301141400011
PM 22415079
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hung, WC
   Ling, XH
   Chang, CC
   Hsu, HF
   Wang, SW
   Lee, YC
   Luo, C
   Lee, YT
   Houng, JY
AF Hung, Wei-Chin
   Ling, Xue-Hua
   Chang, Chi-Chang
   Hsu, Hsia-Fen
   Wang, Shih-Wei
   Lee, Yi-Chen
   Luo, Ci
   Lee, Yun-Tzu
   Houng, Jer-Yiing
TI Inhibitory Effects of Siegesbeckia orientalis Extracts on
   Advanced Glycation End Product Formation and Key Enzymes Related to
   Metabolic Syndrome
SO MOLECULES
LA English
DT Article
DE Siegesbeckia orientalis linne; antioxidation; advanced glycation end
   products; alpha-amylase; alpha-glucosidase; lipase; angiotensin
   I-converting enzyme
ID ANGIOTENSIN-CONVERTING ENZYME; ALPHA-GLUCOSIDASE; PHENOLIC-COMPOUNDS;
   ANTIOXIDANT ACTIVITY; DIETARY POLYPHENOLS; OXIDATIVE STRESS; ETHANOL
   EXTRACT; AMYLASE; OBESITY; COMPLICATIONS
AB Metabolic syndrome typically includes Type 2 diabetes associated with hyperglycemia, central obesity, dyslipidemia and hypertension. It is highly related to oxidative stress, formation of advanced glycated end products (AGEs) and key enzymes, such as carbohydrate digesting enzymes like pancreatic alpha-amylase and intestinal alpha-glucosidase, pancreatic lipase and angiotensin I-converting enzyme (ACE). This study used an in vitro approach to assess the potential of four extracts of Siegesbeckia orientalis linne on key enzymes relevant to metabolic syndrome. In this research, S. orientailis was firstly extracted by ethanol. The ethanol extract (SE) was then partitioned sequentially with hexane, ethyl acetate and methanol, and these extracts were named SE-Hex, SE-EA and SE-MeOH, respectively. The experimental results showed that SE-EA had the highest total phenolic content (TPC, 76.9 +/- 1.8 mg/g) and the total flavonoids content (TFC, 5.3 +/- 0.3 mg/g). This extract exhibited the most significant antioxidant activities, including DPPH radical-scavenging capacity (IC50 = 161.8 +/- 2.4 mu g/mL), ABTS radical-scavenging capacity (IC50 = 13.9 +/- 1.5 mu g/mL) and reducing power. For anti-glycation activities, SE-EA showed the best results in the inhibition of AGEs, as well as inhibitory activities against alpha-glucosidase (IC50 = 362.3 +/- 9.2 mu g/mL) and alpha-amylase (IC50 = 119.0 +/- 17.7 mu g/mL). For anti-obesity activities, SE-EA indicated the highest suppression effect on pancreatic lipase (IC50 = 3.67 +/- 0.52 mg/mL). Finally, for anti-hypertension activity, SE-EA also demonstrated the strongest inhibitory activity on ACE (IC50 = 626.6 +/- 15.0 mu g/mL). Close relationships were observed among the parameters of TPC, antioxidant activities, inhibitory activities on alpha-amylase, alpha-glucosidase, lipase and ACE (R > 0.9). Moderate correlations were found among the parameters of TFC, antioxidant activities, and suppression of dicarbonyl compounds formation (R = 0.5-0.9). Taken together these in vitro studies reveal the therapeutic potential of SE-EA extract in the prevention and treatment of metabolic disorders.
C1 [Hung, Wei-Chin] E Da Hosp, Div Cardiol, Kaohsiung 82445, Taiwan.
   [Ling, Xue-Hua; Houng, Jer-Yiing] I Shou Univ, Grad Inst Biotechnol & Chem Engn, Kaohsiung 84001, Taiwan.
   [Ling, Xue-Hua; Chang, Chi-Chang] I Shou Univ, E Da Hosp, Dept Obstet & Gynecol, Kaohsiung 82445, Taiwan.
   [Hsu, Hsia-Fen; Luo, Ci; Lee, Yun-Tzu; Houng, Jer-Yiing] I Shou Univ, Dept Nutr, Kaohsiung 82445, Taiwan.
   [Wang, Shih-Wei] I Shou Univ, E Da Hosp, Dept Internal Med, Div Allergy Immunol & Rheumatol, Kaohsiung 82445, Taiwan.
   [Lee, Yi-Chen] E Da Hosp, Dept Nutr Therapy, Kaohsiung 82445, Taiwan.
C3 E-Da Hospital; I Shou University; E-Da Hospital; I Shou University; I
   Shou University; I Shou University; E-Da Hospital; E-Da Hospital
RP Houng, JY (corresponding author), I Shou Univ, Grad Inst Biotechnol & Chem Engn, Kaohsiung 84001, Taiwan.; Houng, JY (corresponding author), I Shou Univ, Dept Nutr, Kaohsiung 82445, Taiwan.
EM ed102600@edah.org.tw; ed107312@gmail.com; ed101779@edah.org.tw;
   fen153848@gmail.com; shihwei8888@gmail.com; ed103549@edah.org.tw;
   r9620239@yahoo.com.tw; lisa10143018@gmail.com; jyhoung@isu.edu.tw
RI Houng, Jer-yiing/W-2464-2019
OI Houng, Jer-Yiing/0000-0002-9723-9987
FU E-Da Hospital, Taiwan [EDAHP106027]; I-Shou University [ISU-104-IUC-01];
   Ministry of Science and Technology of Taiwan [MOST102-2221-E-214-037]
FX The authors gratefully acknowledge the financial support of E-Da
   Hospital, Taiwan (EDAHP106027), I-Shou University (ISU-104-IUC-01), and
   the Ministry of Science and Technology of Taiwan
   (MOST102-2221-E-214-037).
CR Anhe Fernando F., 2013, PharmaNutrition, V1, P105, DOI 10.1016/j.phanu.2013.07.004
   Arts ICW, 2005, AM J CLIN NUTR, V81, p317S, DOI 10.1093/ajcn/81.1.317S
   Balasubramaniam V, 2013, J APPL PHYCOL, V25, P1405, DOI 10.1007/s10811-012-9964-4
   Bogaert YE, 2009, NAT CLIN PRACT NEPHR, V5, P101, DOI 10.1038/ncpneph1022
   Cai YZ, 2006, LIFE SCI, V78, P2872, DOI 10.1016/j.lfs.2005.11.004
   Cassel C. K., 1997, GERIATRIC MED, P7
   Chang CC, 2016, MOLECULES, V21, DOI 10.3390/molecules21081021
   Chang CC, 2014, MOLECULES, V19, P19980, DOI 10.3390/molecules191219980
   Cheplick S, 2010, BIORESOURCE TECHNOL, V101, P404, DOI 10.1016/j.biortech.2009.07.068
   CUSHMAN DW, 1971, BIOCHEM PHARMACOL, V20, P1637, DOI 10.1016/0006-2952(71)90292-9
   Dong HQ, 2012, FOOD CHEM, V130, P261, DOI 10.1016/j.foodchem.2011.07.030
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   EPSTEIN M, 1992, HYPERTENSION, V19, P403, DOI 10.1161/01.HYP.19.5.403
   ERDOS EG, 1987, LAB INVEST, V56, P345
   Ranilla LG, 2010, BIORESOURCE TECHNOL, V101, P4676, DOI 10.1016/j.biortech.2010.01.093
   Goh SY, 2008, J CLIN ENDOCR METAB, V93, P1143, DOI 10.1210/jc.2007-1817
   Gu-Joong Kwon, 2007, [Korean Journal of Food Science and Technology, 한국식품과학회지], V39, P569
   Hong YH, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/329712
   Hsu HsiaFen Hsu HsiaFen, 2012, Journal of Medicinal Plants Research, V6, P5002
   Jung HA, 2008, FOOD CHEM TOXICOL, V46, P3818, DOI 10.1016/j.fct.2008.10.004
   Katayama S, 2004, FEBS LETT, V575, P9, DOI 10.1016/j.febslet.2004.08.029
   Kaushik G, 2010, DIAB MET SYND CLIN R, V4, P21, DOI 10.1016/j.dsx.2008.02.006
   Kiselova Y, 2006, PHYTOTHER RES, V20, P961, DOI 10.1002/ptr.1985
   Krogsgaard-Larsen P., 1991, TXB DRUG DESIGN DEV, P302
   Kumar Sunil, 2011, Pharmacogn Rev, V5, P19, DOI 10.4103/0973-7847.79096
   Lacaille-Dubois MA, 2001, PHYTOMEDICINE, V8, P47, DOI 10.1078/0944-7113-00003
   Lean M, 2006, BMJ-BRIT MED J, V333, P959, DOI 10.1136/bmj.333.7575.959
   Lushchak VI, 2014, CHEM-BIOL INTERACT, V224, P164, DOI 10.1016/j.cbi.2014.10.016
   Manaharan T, 2012, FOOD CHEM, V132, P1802, DOI 10.1016/j.foodchem.2011.11.147
   Manaharan T, 2011, FOOD CHEM, V129, P1355, DOI 10.1016/j.foodchem.2011.05.041
   McDougall GJ, 2009, FOOD CHEM, V115, P193, DOI 10.1016/j.foodchem.2008.11.093
   Meng SX, 2013, EVID-BASED COMPL ALT, V2013, DOI [10.1155/2013/801457, 10.1155/2013/702196]
   Nowotny K, 2015, BIOMOLECULES, V5, P194, DOI 10.3390/biom5010194
   Oboh G., 2012, Asian Pacific Journal of Tropical Biomedicine, V2, P733, DOI 10.1016/S2221-1691(12)60219-6
   Oboh G, 2011, J FOOD BIOCHEM, V35, P1703, DOI 10.1111/j.1745-4514.2010.00495.x
   Oboh Ganiyu, 2014, Int J Biomed Sci, V10, P208
   Oboh G, 2011, DIABETES METAB SYND, V5, P148, DOI 10.1016/j.dsx.2012.02.008
   Oliveira Mauren Isfer Anghebem, 2013, J. Bras. Patol. Med. Lab., V49, P97, DOI 10.1590/S1676-24442013000200004
   OYAIZU M, 1986, Japanese Journal of Nutrition, V44, P307
   Palanisamy UD, 2011, FOOD CHEM, V127, P21, DOI 10.1016/j.foodchem.2010.12.070
   Pandey KB, 2012, CURR NUTR FOOD SCI, V8, P254
   Pandey KB, 2009, CURR NUTR FOOD SCI, V5, P249, DOI 10.2174/157340109790218058
   Patra JK, 2015, MOLECULES, V20, P12093, DOI 10.3390/molecules200712093
   Pei KH, 2016, J SCI FOOD AGR, V96, P2952, DOI 10.1002/jsfa.7578
   Ramdath DD, 2014, FOOD FUNCT, V5, P909, DOI 10.1039/c3fo60395d
   Rana JS, 2007, DIABETES OBES METAB, V9, P218, DOI 10.1111/j.1463-1326.2006.00594.x
   Ranilla LG, 2009, J MED FOOD, V12, P704, DOI 10.1089/jmf.2008.0122
   Rasouli H, 2017, FOOD FUNCT, V8, P1942, DOI [10.1039/c7fo00220c, 10.1039/C7FO00220C]
   Sakulnarmrat K, 2012, FOOD CHEM, V134, P1011, DOI 10.1016/j.foodchem.2012.02.217
   Santana-Gálvez J, 2017, MOLECULES, V22, DOI 10.3390/molecules22030358
   Sathyaprakash Roopa, 2002, Curr Diab Rep, V2, P416, DOI 10.1007/s11892-002-0106-2
   Sheliya MA, 2015, J ETHNOPHARMACOL, V176, P1, DOI 10.1016/j.jep.2015.10.018
   Shi YG, 2004, NAT REV DRUG DISCOV, V3, P695, DOI 10.1038/nrd1469
   Shobana S, 2009, FOOD CHEM, V115, P1268, DOI 10.1016/j.foodchem.2009.01.042
   Sreerama YN, 2012, FOOD CHEM, V133, P156, DOI 10.1016/j.foodchem.2012.01.011
   Sun HX, 2006, CHEM BIODIVERS, V3, P754, DOI 10.1002/cbdv.200690077
   Suresh B. P., 1998, MOL CELL BIOCHEM, V181, P87, DOI DOI 10.1023/A:1006821828706
   Syama HP, 2017, J FOOD SCI TECH MYS, V54, P2115, DOI 10.1007/s13197-017-2651-3
   Takenaka K, 2006, CURR NEUROVASC RES, V3, P73, DOI 10.2174/156720206775541804
   Tessier FJ, 2010, PATHOL BIOL, V58, P214, DOI 10.1016/j.patbio.2009.09.014
   Nguyen TD, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1698-z
   Tsai YD, 2014, IND CROP PROD, V57, P98, DOI 10.1016/j.indcrop.2014.03.033
   Tsuji-Naito K, 2009, FOOD CHEM, V116, P854, DOI 10.1016/j.foodchem.2009.03.042
   Wang J.P., 2009, YIYAO DAOBAO, V1, P45
   Wendt Thoralf, 2002, Curr Atheroscler Rep, V4, P228, DOI 10.1007/s11883-002-0024-4
   Worsztynowicz P, 2014, PROCESS BIOCHEM, V49, P1457, DOI 10.1016/j.procbio.2014.06.002
   Wu JW, 2009, FOOD CHEM, V113, P78, DOI 10.1016/j.foodchem.2008.07.025
   Yamagata K, 2015, NUTRITION, V31, P28, DOI 10.1016/j.nut.2014.04.011
   Yamagishi S, 2005, CURR PHARM DESIGN, V11, P2279, DOI 10.2174/1381612054367300
   Yamagishi S, 2003, INT J CLIN PHARM RES, V23, P129
   Yao Y, 2010, J AGR FOOD CHEM, V58, P770, DOI 10.1021/jf903234c
   Zhang B, 2015, FOOD CHEM, V172, P862, DOI 10.1016/j.foodchem.2014.09.144
   Zhang LS, 2011, FOOD CHEM, V124, P183, DOI 10.1016/j.foodchem.2010.06.006
NR 73
TC 16
Z9 16
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD OCT
PY 2017
VL 22
IS 10
AR 1785
DI 10.3390/molecules22101785
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA FM0PZ
UT WOS:000414670600205
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Andersson, G
   Ljótsson, B
   Weise, C
AF Andersson, Gerhard
   Ljotsson, Brjann
   Weise, Cornelia
TI Internet-delivered treatment to promote health
SO CURRENT OPINION IN PSYCHIATRY
LA English
DT Article
DE children and adolescents; Internet interventions; peer support
ID COGNITIVE-BEHAVIOR THERAPY; SELF-MANAGEMENT PROGRAM; PHYSICAL-ACTIVITY;
   WEIGHT-LOSS; SUPPORT; WOMEN; ADOLESCENTS; INTERVENTION; DEPRESSION;
   ARTHRITIS
AB Purpose of review
   The aim of this paper is to provide an updated review of recent controlled trials of Internet interventions for health conditions and how the Internet is used to promote health.
   Recent findings
   We identified 18 published trials including studies on diabetes, cancer, pain conditions, obesity, irritable bowel syndrome, stress management, hypertension, metabolic syndrome, cerebral palsy, infertility, HIV infection, and fruit/vegetable consumption. Of the 18 trials, one-third targeted children and adolescents. Two cancer studies investigated the role of peer support in an online environment that failed to result in any major improvements. Overall, several trials did not result in any substantial significant improvements, but there are exceptions, such as treatment of irritable bowel syndrome, headache, and chronic pain. Although a few of the reviewed studies had sufficient sample sizes, the majority were small and underpowered. In particular, this was the case for the studies on children and adolescents.
   Summary
   This review suggests that Internet interventions hold some promise as a complement to other treatments such as cognitive behavior therapy. The benefits from participating in online peer support groups are not clear. Although studies on children and adolescents have emerged, there is a lack of studies on older adults with health problems.
C1 [Andersson, Gerhard; Weise, Cornelia] Linkoping Univ, Dept Behav Sci & Learning, Swedish Inst Disabil Res, SE-58183 Linkoping, Sweden.
   [Andersson, Gerhard; Ljotsson, Brjann] Karolinska Inst, Psychiat Sect, Dept Clin Neurosci, Stockholm, Sweden.
C3 Linkoping University; Karolinska Institutet
RP Andersson, G (corresponding author), Linkoping Univ, Dept Behav Sci & Learning, Swedish Inst Disabil Res, SE-58183 Linkoping, Sweden.
EM Gerhard.Andersson@liu.se
RI Weise, Cornelia/G-6825-2013; Andersson, Gerhard/J-8529-2012
OI Weise, Cornelia/0000-0001-5216-1031; Andersson,
   Gerhard/0000-0003-4753-6745; Ljotsson, Brjann/0000-0001-8086-1668
FU Linneus centre head in Linkoping, Sweden; Swedish Research Council;
   Swedish council for working and life research; European Community
FX The authors have no conflict of interest. G. A. and C. W. are sponsored
   in part by a grant for the Linneus centre head in Linkoping, Sweden. G.
   A. has funding from the Swedish Research Council, the Swedish council
   for working and life research and the European Community.
CR Alexander GL, 2010, AM J PUBLIC HEALTH, V100, P319, DOI 10.2105/AJPH.2008.154468
   Andersson Gerhard, 2009, Cognitive Behaviour Therapy, V38, P196, DOI 10.1080/16506070903318960
   Andersson G, 2009, BEHAV RES THER, V47, P175, DOI 10.1016/j.brat.2009.01.010
   Barak A, 2009, ANN BEHAV MED, V38, P4, DOI 10.1007/s12160-009-9130-7
   Bergström J, 2010, BMC PSYCHIATRY, V10, DOI 10.1186/1471-244X-10-54
   Bosak KA, 2010, WESTERN J NURS RES, V32, P5, DOI 10.1177/0193945909333889
   Carpenter KM, 2010, AIDS BEHAV, V14, P549, DOI 10.1007/s10461-009-9578-2
   Cuijpers P, 2008, J BEHAV MED, V31, P169, DOI 10.1007/s10865-007-9144-1
   Fogel J, 2002, HEALTH PSYCHOL, V21, P398, DOI 10.1037/0278-6133.21.4.398
   Haemmerli K, 2010, J BEHAV MED, V33, P135, DOI 10.1007/s10865-009-9243-2
   Hoybye MT, 2010, BRIT J CANCER, V102, P1348, DOI 10.1038/sj.bjc.6605646
   Hunt MG, 2009, BEHAV RES THER, V47, P797, DOI 10.1016/j.brat.2009.05.002
   Kaldo V, 2008, BEHAV THER, V39, P348, DOI 10.1016/j.beth.2007.10.003
   Kaldo-Sandstrom Viktor, 2004, Am J Audiol, V13, P185, DOI 10.1044/1059-0889(2004/023)
   Kiropoulos LA, 2008, J ANXIETY DISORD, V22, P1273, DOI 10.1016/j.janxdis.2008.01.008
   Lelieveld OTHM, 2010, ARTHRIT CARE RES, V62, P697, DOI 10.1002/acr.20085
   Ljótsson B, 2010, BEHAV RES THER, V48, P531, DOI 10.1016/j.brat.2010.03.003
   Lorig K, 2010, DIABETES CARE, V33, P1275, DOI 10.2337/dc09-2153
   Maher CA, 2010, DEV MED CHILD NEUROL, V52, P448, DOI 10.1111/j.1469-8749.2009.03609.x
   Mulvaney SA, 2010, DIABETES CARE, V33, P602, DOI 10.2337/dc09-1881
   Olsson EMG, 2010, APPL PSYCHOPHYS BIOF, V35, P163, DOI 10.1007/s10484-009-9126-x
   Palermo TM, 2009, PAIN, V146, P205, DOI 10.1016/j.pain.2009.07.034
   Ritterband LM, 2003, J CONSULT CLIN PSYCH, V71, P910, DOI 10.1037/0022-006X.71.5.910
   Salzer MS, 2010, PSYCHO-ONCOLOGY, V19, P441, DOI 10.1002/pon.1586
   Spek V, 2007, PSYCHOL MED, V37, P319, DOI 10.1017/S0033291706008944
   Stinson JN, 2010, J RHEUMATOL, V37, P1944, DOI 10.3899/jrheum.091327
   Tate DF, 2001, JAMA-J AM MED ASSOC, V285, P1172, DOI 10.1001/jama.285.9.1172
   Tate DF, 2003, JAMA-J AM MED ASSOC, V289, P1833, DOI 10.1001/jama.289.14.1833
   Trautmann E, 2010, BEHAV RES THER, V48, P28, DOI 10.1016/j.brat.2009.09.004
   Wantland DJ, 2004, J MED INTERNET RES, V6, P67
   Whittemore R, 2010, CIN-COMPUT INFORM NU, V28, P103, DOI 10.1097/NCN.0b013e3181cd8199
   Wiegand B, 2010, CURR MED RES OPIN, V26, P991, DOI 10.1185/03007991003688193
   Winzelberg AJ, 2003, CANCER-AM CANCER SOC, V97, P1164, DOI 10.1002/cncr.11174
   Zetterqvist Kristofer, 2003, Cognitive Behaviour Therapy, V32, P151, DOI 10.1080/16506070302316
NR 34
TC 32
Z9 40
U1 0
U2 44
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0951-7367
EI 1473-6578
J9 CURR OPIN PSYCHIATR
JI Curr. Opin. Psychiatr.
PD MAR
PY 2011
VL 24
IS 2
BP 168
EP 172
DI 10.1097/YCO.0b013e3283438028
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 715IH
UT WOS:000286876300014
PM 21285706
DA 2025-06-11
ER

PT J
AU Packard, AEB
   Ghosal, S
   Herman, JP
   Woods, SC
   Ulrich-Lai, YM
AF Packard, Amy E. B.
   Ghosal, Sriparna
   Herman, James P.
   Woods, Stephen C.
   Ulrich-Lai, Yvonne M.
TI Chronic variable stress improves glucose tolerance in rats with
   sucrose-induced prediabetes
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Chronic stress; Glucose tolerance; Type 2 diabetes; Insulin
ID DIABETIC FATTY RAT; INDUCED PROLONGED STRESS; INSULIN-RESISTANCE;
   FOOD-INTAKE; METABOLIC SYNDROME; GLYCEMIC CONTROL; ADRENAL AXIS;
   OBESITY; MELLITUS; LEPTIN
AB The incidence of type-2 diabetes (T2D) and the burden it places on individuals, as well as society as a whole, compels research into the causes, factors and progression of this disease. Epidemiological studies suggest that chronic stress exposure may contribute to the development and progression of T2D in human patients. To address the interaction between chronic stress and the progression of T2D, we developed a dietary model of the prediabetic state in rats utilizing unlimited access to 30% sucrose solution (in addition to unlimited access to normal chow and water), which led to impaired glucose tolerance despite elevated insulin levels. We then investigated the effects of a chronic variable stress paradigm (CVS; twice daily exposure to an unpredictable stressor for 2 weeks) on metabolic outcomes in this prediabetic model. Chronic stress improved glucose tolerance in prediabetic rats following a glucose challenge. Importantly, pair-fed control groups revealed that the beneficial effect of chronic stress did not result from the decreased food intake or body weight gain that occurred during chronic stress. The present work suggests that chronic stress in rodents can ameliorate the progression of diet-induced prediabetic disease independent of chronic stress-induced decreases in food intake and body weight. (C) 2014 Elsevier Ltd. All rights reserved.
C1 Univ Cincinnati, Dept Psychiat & Behav Neurosci, Cincinnati, OH 45237 USA.
C3 University System of Ohio; University of Cincinnati
RP Packard, AEB (corresponding author), Univ Cincinnati, Dept Psychiat & Behav Neurosci, 2180 E Galbraith Rd ML0506, Cincinnati, OH 45237 USA.
EM amy.packard@uc.edu
RI ; Packard, Amy/I-5405-2013; Herman, James/D-4960-2015
OI Ghosal, Sriparna/0000-0003-4471-6230; Packard, Amy/0000-0003-1057-8853;
   Herman, James/0000-0003-3571-2406; Ulrich-Lai,
   Yvonne/0000-0002-9245-0919
FU  [K01 DK078906];  [R01 DK091425]
FX This work was supported by K01 DK078906 (Y.M.U.) and R01 DK091425
   (Y.M.U.).
CR Abdul-Ghani MA, 2006, DIABETES CARE, V29, P1130, DOI 10.2337/dc05-2179
   Alexandraki K, 2006, ANN NY ACAD SCI, V1084, P89, DOI 10.1196/annals.1372.039
   [Anonymous], 2011, National Diabetes Fact Sheet: National Estimates and General Information on Diabetes and Prediabetes in the United States, 2011
   Bates HE, 2008, ENDOCRINOLOGY, V149, P2990, DOI 10.1210/en.2007-1473
   Bates HE, 2007, METABOLISM, V56, P1065, DOI 10.1016/j.metabol.2007.03.015
   BRADLEY C, 1979, J PSYCHOSOM RES, V23, P159, DOI 10.1016/0022-3999(79)90021-7
   Cherrington AD, 1999, DIABETES, V48, P1198, DOI 10.2337/diabetes.48.5.1198
   Cnop M, 2003, DIABETOLOGIA, V46, P459, DOI 10.1007/s00125-003-1074-z
   Dallman MF, 2003, P NATL ACAD SCI USA, V100, P11696, DOI 10.1073/pnas.1934666100
   De Souza CT, 2005, ENDOCRINOLOGY, V146, P4192, DOI 10.1210/en.2004-1520
   DEIBERT DC, 1980, J CLIN INVEST, V65, P717, DOI 10.1172/JCI109718
   Duong M, 2012, ENDOCRINE, V41, P76, DOI 10.1007/s12020-011-9527-5
   Epel E, 2004, ANN NY ACAD SCI, V1032, P208, DOI 10.1196/annals.1314.022
   ESCRIVA F, 1992, AM J PHYSIOL, V263, pE1, DOI 10.1152/ajpendo.1992.263.1.E1
   Faghihimani E, 2012, ENDOCR PRACT, V18, P826, DOI 10.4158/EP12064.OR
   Faulenbach M, 2012, DIABETIC MED, V29, P128, DOI 10.1111/j.1464-5491.2011.03431.x
   Flak JN, 2011, PHYSIOL BEHAV, V104, P228, DOI 10.1016/j.physbeh.2011.03.002
   Foster MT, 2013, PHYSIOL REP, V1, DOI 10.1002/phy2.15
   Fransson L, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-3
   GRIFFITH LS, 1990, INT J PSYCHIAT MED, V20, P365, DOI 10.2190/APH4-YMBG-NVRL-VLWD
   GUILLAUMEGENTIL C, 1990, ENDOCRINOLOGY, V126, P1873, DOI 10.1210/endo-126-4-1873
   HERMAN JP, 1995, NEUROENDOCRINOLOGY, V61, P180, DOI 10.1159/000126839
   Iwamoto J, 2011, ARTHRITIS, DOI 10.1155/2011/580632
   JASPER MS, 1991, AM J PHYSIOL, V261, pR1257, DOI 10.1152/ajpregu.1991.261.5.R1257
   Kai K, 2000, PHYSIOL BEHAV, V68, P445, DOI 10.1016/S0031-9384(99)00187-0
   Király MA, 2007, METABOLISM, V56, P732, DOI 10.1016/j.metabol.2006.12.022
   Kleinridders A, 2009, CELL METAB, V10, P249, DOI 10.1016/j.cmet.2009.08.013
   Levin BE, 2000, AM J PHYSIOL-REG I, V278, pR231, DOI 10.1152/ajpregu.2000.278.1.R231
   Malik VS, 2010, DIABETES CARE, V33, P2477, DOI 10.2337/dc10-1079
   Manenschijn L, 2013, J CLIN ENDOCR METAB, V98, P2078, DOI 10.1210/jc.2012-3663
   Mastronardi CA, 2002, P NATL ACAD SCI USA, V99, P5721, DOI 10.1073/pnas.082098499
   NALIBOFF BD, 1985, J PSYCHOSOM RES, V29, P367, DOI 10.1016/0022-3999(85)90022-4
   Nunes S, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-44
   Oliver G, 1999, PHYSIOL BEHAV, V66, P511, DOI 10.1016/S0031-9384(98)00322-9
   PIBERNIKOKANOVIC M, 1993, PSYCHOL MED, V23, P645, DOI 10.1017/S0033291700025423
   Reynolds RM, 2010, J CLIN ENDOCR METAB, V95, P1602, DOI 10.1210/jc.2009-2112
   ROGLIC G, 1993, BEHAV MED, V19, P53, DOI 10.1080/08964289.1993.9937565
   Romaguera D, 2013, DIABETOLOGIA, V56, P1520, DOI 10.1007/s00125-013-2899-8
   Rosen ED, 2006, NATURE, V444, P847, DOI 10.1038/nature05483
   Rowland NE, 2005, PHARMACOL BIOCHEM BE, V80, P109, DOI 10.1016/j.pbb.2004.10.010
   Smith J, 2006, NUTR METAB, V3, DOI 10.1186/1743-7075-3-18
   Torres SJ, 2007, NUTRITION, V23, P887, DOI 10.1016/j.nut.2007.08.008
   Ulrich-Lai Y.M., 2014, CELL METAB
   Ulrich-Lai YM, 2006, AM J PHYSIOL-ENDOC M, V291, pE965, DOI 10.1152/ajpendo.00070.2006
   Ulrich-Lai YM, 2009, NAT REV NEUROSCI, V10, P397, DOI 10.1038/nrn2647
   Vahl TP, 2010, ENDOCRINOLOGY, V151, P569, DOI 10.1210/en.2009-1002
   Weinstein SE, 1997, APPETITE, V28, P7, DOI 10.1006/appe.1996.0056
   Zhang XQ, 2008, CELL, V135, P61, DOI 10.1016/j.cell.2008.07.043
   Ziegler D, 2005, CURR MOL MED, V5, P309, DOI 10.2174/1566524053766095
NR 49
TC 33
Z9 36
U1 0
U2 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD SEP
PY 2014
VL 47
BP 178
EP 188
DI 10.1016/j.psyneuen.2014.05.016
PG 11
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA AM2PY
UT WOS:000339694500019
PM 25001967
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Jurgonski, A
   Juskiewicz, J
   Zdunczyk, Z
   Król, B
AF Jurgonski, Adam
   Juskiewicz, Jerzy
   Zdunczyk, Zenon
   Krol, Boguslaw
TI Caffeoylquinic acid-rich extract from chicory seeds improves glycemia,
   atherogenic index, and antioxidant status in rats
SO NUTRITION
LA English
DT Article
DE Chicory; Caffeoylquinic acids; Chlorogenic acid; Rutin; The metabolic
   syndrome
ID CYNARA-SCOLYMUS L.; OXIDATIVE STRESS; BIOLOGICAL-PROPERTIES; BRAZILIAN
   PROPOLIS; PHENOLIC-COMPOUNDS; CHLOROGENIC ACID; IN-VIVO; FRUCTOSE;
   IDENTIFICATION; RUTIN
AB Objective: Comparison of the effects of a high-fructose diet supplemented with rutin, a phenolic compound with well-recognized bioavailability and bioactivity, and a chicory (Cichorium intybus L.) seed extract rich in caffeoylquinic acids (CQA) on gut physiology and the development of disorders related to metabolic syndrome.
   Methods: A 28-d experiment was conducted on 32 young male Wistar rats. In comparison with control rats fed a standard corn starch diet (group C), the experimental group (group E) was fed a diet with an increased content of cholesterol and fructose (to 1% and 66% of the diet, respectively), as well as with oxidized soybean oil. Rats from the other two experimental groups were administered the same diet as group E during the first 2 wk of feeding, whereas at the beginning of the last 2 wk, the diet was enriched with rutin (group ER) or the CQA-rich ethanol extract from chicory seeds (9.6% of CQA, group EC), so the amount of added phenolics was equal in both dietary groups (0.15%).
   Results: The diet administered in group E caused hyperglycemia and increased blood serum atherogenicity in rats, but did not induce other manifestations of the metabolic syndrome, i.e., dyslipidemia and oxidative stress. Additionally, it affected gut physiology through increasing mucosal sucrase activity and disturbing fermentative processes in the cecum, such as the production of short-chain fatty acids and the activity of microbial enzymes. Similarly to rutin, the dietary addition of the chicory seed extract improved glycemia, which was comparable to that determined in group C. In addition, the extract was found to decrease the atherogenic index to the level observed in group C and to increase blood antioxidant status. Both dietary supplements reduced the content of thiobarbituric acid-reactive substances in kidney and heart tissue when compared with group E.
   Conclusion: The potential efficacy of the CQA-rich extract from chicory seeds in improving diet-induced metabolic disturbances proved to be better than that of rutin; thus, the extract might be considered as a dietary supplement for carrying out clinical trials. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Jurgonski, Adam; Juskiewicz, Jerzy; Zdunczyk, Zenon] Polish Acad Sci, Div Food Sci, Inst Anim Reprod & Food Res, Olsztyn, Poland.
   [Krol, Boguslaw] Tech Univ Lodz, Inst Chem Technol Food, PL-90924 Lodz, Poland.
C3 Polish Academy of Sciences; Institute of Animal Reproduction & Food
   Research of the Polish Academy of Sciences; Lodz University of
   Technology
RP Jurgonski, A (corresponding author), Polish Acad Sci, Div Food Sci, Inst Anim Reprod & Food Res, Olsztyn, Poland.
EM a.jurgonski@pan.olsztyn.pl
RI JURGONSKI, Adam/A-5864-2009; ZDUNCZYK, Zenon/H-7272-2017; JUSKIEWICZ,
   Jerzy/H-7193-2017
OI JURGONSKI, Adam/0000-0003-3524-3259; ZDUNCZYK,
   Zenon/0000-0002-0640-7552; JUSKIEWICZ, Jerzy/0000-0003-0068-5970
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Atta-Ur-Rahman, 2008, J NAT PROD, V71, P910, DOI 10.1021/np800001v
   Azuma K, 2000, J AGR FOOD CHEM, V48, P5496, DOI 10.1021/jf000483q
   Beylot M, 2005, BRIT J NUTR, V93, pS163, DOI 10.1079/BJN20041339
   Bischoff SC, 2008, CURR OPIN CLIN NUTR, V11, P733, DOI 10.1097/MCO.0b013e32831394b8
   BRAND-WILLIAMS W, 1995, FOOD SCI TECHNOL-LEB, V28, P25
   Busserolles J, 2003, J NUTR, V133, P1903, DOI 10.1093/jn/133.6.1903
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Cho AS, 2010, FOOD CHEM TOXICOL, V48, P937, DOI 10.1016/j.fct.2010.01.003
   Choi J, 2005, J MED FOOD, V8, P348, DOI 10.1089/jmf.2005.8.348
   Cirillo P, 2009, J AM SOC NEPHROL, V20, P545, DOI 10.1681/ASN.2008060576
   Cui CB, 2009, J KOREAN SOC APPL BI, V52, P655, DOI 10.3839/jksabc.2009.109
   DAHLQVIST A, 1964, ANAL BIOCHEM, V7, P18, DOI 10.1016/0003-2697(64)90115-0
   de Moura RF, 2009, BRIT J NUTR, V101, P1178, DOI 10.1017/S0007114508066774
   DRAPER HH, 1990, METHOD ENZYMOL, V186, P421
   Fernandes AAH, 2010, BIOMED PHARMACOTHER, V64, P214, DOI 10.1016/j.biopha.2009.08.007
   Hofírek B, 2001, ACTA VET BRNO, V70, P27, DOI 10.2754/avb200170010027
   Hsu CL, 2009, J AGR FOOD CHEM, V57, P425, DOI 10.1021/jf802715t
   Johnston KL, 2003, AM J CLIN NUTR, V78, P728, DOI 10.1093/ajcn/78.4.728
   Jurgonski A, 2011, FOOD TECHNOL BIOTECH, V49, P40
   Juskiewicz J, 2011, NUTRITION, V27, P351, DOI 10.1016/j.nut.2010.02.002
   Kamalakkannan N, 2006, MOL CELL BIOCHEM, V293, P211, DOI 10.1007/s11010-006-9244-1
   Kishi K, 1999, J NUTR BIOCHEM, V10, P8, DOI 10.1016/S0955-2863(98)00071-0
   Mabeau S, 2006, ACTA HORTIC, P491
   Matsui T, 2004, BIOL PHARM BULL, V27, P1797, DOI 10.1248/bpb.27.1797
   Misciagna G, 2007, CURR PHARM DESIGN, V13, P3688, DOI 10.2174/138161207783018545
   Mishima S, 2005, BIOL PHARM BULL, V28, P1909, DOI 10.1248/bpb.28.1909
   Onat A, 2010, J CLIN LIPIDOL, V4, P89, DOI 10.1016/j.jacl.2010.02.005
   Papetti A, 2008, J PHARMACEUT BIOMED, V48, P472, DOI 10.1016/j.jpba.2008.04.014
   SCHEFFLER W, 1980, ARTERY, V8, P120
   Schütz K, 2004, J AGR FOOD CHEM, V52, P4090, DOI 10.1021/jf049625x
   Selma MV, 2009, J AGR FOOD CHEM, V57, P6485, DOI 10.1021/jf902107d
   Skoog SM, 2004, AM J GASTROENTEROL, V99, P2046, DOI 10.1111/j.1572-0241.2004.40266.x
   Tappy L, 2010, NUTRITION, V26, P1044, DOI 10.1016/j.nut.2010.02.014
   Van den Ende W, 2009, J EXP BOT, V60, P9, DOI 10.1093/jxb/ern297
   Wilson R, 2002, FREE RADICAL BIO MED, V32, P162, DOI 10.1016/S0891-5849(01)00780-8
   Wittemer SM, 2005, PHYTOMEDICINE, V12, P28, DOI 10.1016/j.phymed.2003.11.002
   Yang B, 2005, DRUG METAB DISPOS, V33, P930, DOI 10.1124/dmd.104.002154
   Yim MB, 2001, ANN NY ACAD SCI, V928, P48, DOI 10.1111/j.1749-6632.2001.tb05634.x
   Zdunczyk Z, 2005, ARCH ANIM NUTR, V59, P247, DOI 10.1080/17450390500216944
   Zhu XF, 2004, J AGR FOOD CHEM, V52, P7272, DOI 10.1021/jf0490192
   Ziaee A, 2009, BASIC CLIN PHARMACOL, V104, P253, DOI 10.1111/j.1742-7843.2008.00368.x
NR 42
TC 37
Z9 41
U1 1
U2 41
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD MAR
PY 2012
VL 28
IS 3
BP 300
EP 306
DI 10.1016/j.nut.2011.06.010
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 895TL
UT WOS:000300519200014
PM 22014632
DA 2025-06-11
ER

PT J
AU Catalano, PM
   Shankar, K
AF Catalano, Patrick M.
   Shankar, Kartik
TI Obesity and pregnancy: mechanisms of short term and long term adverse
   consequences for mother and child
SO BMJ-BRITISH MEDICAL JOURNAL
LA English
DT Review
ID BODY-MASS INDEX; GESTATIONAL WEIGHT-GAIN; OF-MEDICINE RECOMMENDATIONS;
   LIFE-STYLE INTERVENTION; MATERNAL OBESITY; DENSITY-LIPOPROTEIN;
   METABOLIC SYNDROME; CESAREAN DELIVERY; FOLLICULAR-FLUID; AMINO-ACID
AB Obesity is the most common medical condition in women of reproductive age. Obesity during pregnancy has short term and long term adverse consequences for both mother and child. Obesity causes problems with infertility, and in early gestation it causes spontaneous pregnancy loss and congenital anomalies. Metabolically, obese women have increased insulin resistance in early pregnancy, which becomes manifest clinically in late gestation as glucose intolerance and fetal overgrowth. At term, the risk of cesarean delivery and wound complications is increased. Postpartum, obese women have an increased risk of venous thromboembolism, depression, and difficulty with breast feeding. Because 50-60% of overweight or obese women gain more than recommended by Institute of Medicine gestational weight guidelines, postpartum weight retention increases future cardiometabolic risks and prepregnancy obesity in subsequent pregnancies. Neonates of obese women have increased body fat at birth, which increases the risk of childhood obesity. Although there is no unifying mechanism responsible for the adverse perinatal outcomes associated with maternal obesity, on the basis of the available data, increased prepregnancy maternal insulin resistance and accompanying hyperinsulinemia, inflammation, and oxidative stress seem to contribute to early placental and fetal dysfunction. We will review the pathophysiology underlying these data and try to shed light on the specific underlying mechanisms
C1 [Catalano, Patrick M.] MetroHlth Med Ctr, Ctr Reprod Hlth, Dept Obstet & Gynecol, Cleveland, OH USA.
   [Catalano, Patrick M.] Case Western Reserve Univ, Cleveland, OH 44106 USA.
   [Shankar, Kartik] Univ Arkansas Med Sci, Arkansas Childrens Nutr Ctr, Little Rock, AR 72205 USA.
   [Shankar, Kartik] Univ Arkansas Med Sci, Dept Pediat, Little Rock, AR 72205 USA.
C3 MetroHealth System; University System of Ohio; Case Western Reserve
   University; University of Arkansas System; University of Arkansas
   Medical Sciences; University of Arkansas System; University of Arkansas
   Medical Sciences
RP Catalano, PM (corresponding author), MetroHlth Med Ctr, Ctr Reprod Hlth, Dept Obstet & Gynecol, Cleveland, OH USA.; Catalano, PM (corresponding author), Case Western Reserve Univ, Cleveland, OH 44106 USA.
EM pcatalano@metrohealth.org
RI Catalano, Patrick/GVR-9069-2022
OI Shankar, Kartik/0000-0002-7964-9026
FU Eunice Kennedy Shriver National Institute of Child Health and
   development [HD-11089-19]; USDA Agricultural Research Service CRIS
   [625151000-010-05S]
FX The authors are supported in part by the following grants: Eunice
   Kennedy Shriver National Institute of Child Health and development
   HD-11089-19 (PMC) and USDA Agricultural Research Service CRIS
   625151000-010-05S (KS).
CR Alderete TL, 2015, AM J CLIN NUTR, V102, P1381, DOI 10.3945/ajcn.115.115451
   Alvarez JJ, 1996, J LIPID RES, V37, P299
   [Anonymous], 2015, Obstet Gynecol, V125, P1268, DOI 10.1097/01.AOG.0000465192.34779.dc
   [Anonymous], 2011, Obstet Gynecol, V117, P1472, DOI 10.1097/AOG.0b013e3182238c31
   [Anonymous], OBSTET NORM IN PRESS
   [Anonymous], SOC REPR INV 62 ANN
   [Anonymous], 2011, The Global Health Observatory
   [Anonymous], MAN WOM OB PREGN CMA
   [Anonymous], DAT STAT CHALL OB QU
   Aris IM, 2015, AM J CLIN NUTR, V102, P1104, DOI 10.3945/ajcn.115.117614
   Aune D, 2014, JAMA-J AM MED ASSOC, V311, P1536, DOI 10.1001/jama.2014.2269
   Barba C, 2004, LANCET, V363, P157, DOI 10.1016/s0140-6736(03)15268-3
   Basu S, 2011, OBESITY, V19, P476, DOI 10.1038/oby.2010.215
   Bausenwein J, 2010, MOL HUM REPROD, V16, P117, DOI 10.1093/molehr/gap078
   Bellver J, 2013, FERTIL STERIL, V100, P1050, DOI 10.1016/j.fertnstert.2013.06.001
   Bellver J, 2011, FERTIL STERIL, V95, P2335, DOI 10.1016/j.fertnstert.2011.03.021
   Blumfield M, 2012, NUTRIENTS, V4, P1958, DOI 10.3390/nu4121958
   Bodnar LM, 2010, AM J CLIN NUTR, V91, P1642, DOI 10.3945/ajcn.2009.29008
   Bogaerts A, 2013, OBSTET GYNECOL, V122, P999, DOI 10.1097/AOG.0b013e3182a7f63e
   Boney CM, 2005, PEDIATRICS, V115, pE290, DOI 10.1542/peds.2004-1808
   Boots CE, 2014, FERTIL STERIL, V102, P455, DOI 10.1016/j.fertnstert.2014.05.005
   Brass E, 2013, PLACENTA, V34, P503, DOI 10.1016/j.placenta.2013.03.009
   Brite J, 2014, INT J OBESITY, V38, P878, DOI 10.1038/ijo.2013.244
   Calabuig-Navarro V, 2016, AM J CLIN NUTR, V103, P1064, DOI 10.3945/ajcn.115.124651
   Collado MC, 2012, PEDIATR RES, V72, P77, DOI 10.1038/pr.2012.42
   Catalano PM, 2007, OBSTET GYNECOL, V109, P419, DOI 10.1097/01.AOG.0000253311.44696.85
   Catalano PM, 2015, OBSTET GYNECOL, V126, pe112, DOI 10.1097/AOG.0000000000001211
   Catalano PM, 2014, AM J OBSTET GYNECOL, V211, DOI 10.1016/j.ajog.2014.02.004
   Catalano PM, 2012, DIABETES CARE, V35, P780, DOI 10.2337/dc11-1790
   Catalano PM, 2009, DIABETES CARE, V32, P1076, DOI 10.2337/dc08-2077
   Catalano PM, 1999, AM J OBSTET GYNECOL, V180, P903, DOI 10.1016/S0002-9378(99)70662-9
   CATALANO PM, 1993, AM J PHYSIOL, V264, pE60, DOI 10.1152/ajpendo.1993.264.1.E60
   CATALANO PM, 1992, OBSTET GYNECOL, V79, P46
   Challier JC, 2008, PLACENTA, V29, P274, DOI 10.1016/j.placenta.2007.12.010
   Chandler-Laney PC, 2011, DIABETES CARE, V34, P741, DOI 10.2337/dc10-1503
   Chen YH, 2012, AM J OBSTET GYNECOL, V207, DOI 10.1016/j.ajog.2012.08.023
   Chu SY, 2007, OBES REV, V8, P385, DOI 10.1111/j.1467-789X.2007.00397.x
   Chu SY, 2007, DIABETES CARE, V30, P2070, DOI 10.2337/dc06-2559a
   Cnattingius S, 2013, JAMA-J AM MED ASSOC, V309, P2362, DOI 10.1001/jama.2013.6295
   Colleran HL, 2012, J ACAD NUTR DIET, V112, P553, DOI 10.1016/j.jand.2011.12.004
   Correa A, 2013, NUTR REV, V71, pS68, DOI 10.1111/nure.12058
   Coyne K, 2016, INT J OBESITY, V40, P171, DOI 10.1038/ijo.2015.159
   Crume TL, 2016, AM J OBSTET GYNECOL, V215, DOI 10.1016/j.ajog.2016.06.035
   Crume TL, 2015, J CLIN ENDOCR METAB, V100, P1672, DOI 10.1210/jc.2014-2949
   Danielsen I, 2014, OBESITY, V22, P1351, DOI 10.1002/oby.20650
   de Agüero MG, 2016, SCIENCE, V351, P1296, DOI 10.1126/science.aad2571
   Di Cesare M, 2016, LANCET, V387, P1377, DOI 10.1016/s0140-6736(16)30054-x
   Díaz P, 2014, BIOL REPROD, V91, DOI 10.1095/biolreprod.114.121798
   DiGiulio DB, 2015, P NATL ACAD SCI USA, V112, P11060, DOI 10.1073/pnas.1502875112
   Ditchfield AM, 2015, INT J OBESITY, V39, P557, DOI 10.1038/ijo.2014.212
   Dodd JM, 2010, BJOG-INT J OBSTET GY, V117, P1316, DOI 10.1111/j.1471-0528.2010.02540.x
   Dodd JM, 2014, BMJ-BRIT MED J, V348, DOI 10.1136/bmj.g1285
   Dolinoy DC, 2007, PEDIATR RES, V61, p30R, DOI 10.1203/pdr.0b013e31804575f7
   Donahue SMA, 2011, AM J CLIN NUTR, V93, P780, DOI 10.3945/ajcn.110.005801
   Dresner M, 2006, BJOG-INT J OBSTET GY, V113, P1178, DOI 10.1111/j.1471-0528.2006.01048.x
   Dubé E, 2012, BIOL REPROD, V87, DOI 10.1095/biolreprod.111.098095
   Duhl AJ, 2007, AM J OBSTET GYNECOL, V197, DOI 10.1016/j.ajog.2007.04.022
   Ehrlich SF, 2011, OBSTET GYNECOL, V117, P1323, DOI 10.1097/AOG.0b013e31821aa358
   El Hajj N, 2013, DIABETES, V62, P1320, DOI 10.2337/db12-0289
   FAHRAEUS L, 1985, OBSTET GYNECOL, V66, P468
   Farah N, 2012, CYTOKINE, V60, P96, DOI 10.1016/j.cyto.2012.05.024
   Farley DM, 2010, PLACENTA, V31, P718, DOI 10.1016/j.placenta.2010.06.006
   Faucett AM, 2016, AM J PERINAT, V33, P991, DOI 10.1055/s-0036-1580609
   Fernández-Barrés S, 2016, PEDIATR OBES, V11, P491, DOI 10.1111/ijpo.12092
   Fields DA, 2012, PEDIATR OBES, V7, P304, DOI 10.1111/j.2047-6310.2012.00059.x
   Flegal KM, 2012, JAMA-J AM MED ASSOC, V307, P491, DOI 10.1001/jama.2012.39
   Flegal KM, 2010, JAMA-J AM MED ASSOC, V303, P235, DOI 10.1001/jama.2009.2014
   Fraser A, 2011, AM J CLIN NUTR, V93, P1285, DOI 10.3945/ajcn.110.008326
   Friis CM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057467
   Friis CM, 2013, OBESITY, V21, pE124, DOI 10.1002/oby.20120
   Gaillard R, 2016, OBESITY, V24, P1320, DOI 10.1002/oby.21484
   Gauster M, 2011, DIABETES, V60, P2457, DOI 10.2337/db10-1434
   Gemma C, 2009, OBESITY, V17, P1032, DOI 10.1038/oby.2008.605
   Getahun D, 2007, AM J OBSTET GYNECOL, V196, P530, DOI 10.1016/j.ajog.2006.12.036
   Glazer NL, 2004, EPIDEMIOLOGY, V15, P733, DOI 10.1097/01.ede.0000142151.16880.03
   Godfrey KM, 2017, LANCET DIABETES ENDO, V5, P53, DOI 10.1016/S2213-8587(16)30107-3
   Godfrey KM, 2011, DIABETES, V60, P1528, DOI 10.2337/db10-0979
   Guénard F, 2013, P NATL ACAD SCI USA, V110, P11439, DOI 10.1073/pnas.1216959110
   Gunderson EP, 2015, ANN INTERN MED, V163, P889, DOI 10.7326/M15-0807
   Gunderson EP, 2009, OBSTET GYN CLIN N AM, V36, P317, DOI 10.1016/j.ogc.2009.04.001
   Hadiati DR, 2014, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007462.pub3
   Han SS, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009021.pub2
   Harmon KA, 2011, DIABETES CARE, V34, P2198, DOI 10.2337/dc11-0723
   Hibbard JU, 2006, OBSTET GYNECOL, V108, P125, DOI 10.1097/01.AOG.0000223871.69852.31
   Hull HR, 2008, AM J OBSTET GYNECOL, V198, DOI 10.1016/j.ajog.2007.10.796
   Huypens P, 2016, NAT GENET, V48, P497, DOI 10.1038/ng.3527
   Jain AP, 2013, AM J OBSTET GYNECOL, V208, DOI 10.1016/j.ajog.2012.12.018
   Jansson N, 2013, J CLIN ENDOCR METAB, V98, P105, DOI 10.1210/jc.2012-2667
   JONES CJP, 1993, AM J REPROD IMMUNOL, V30, P136, DOI 10.1111/j.1600-0897.1993.tb00614.x
   Juhasz G, 2005, OBSTET GYNECOL, V106, P741, DOI 10.1097/01.AOG.0000177972.32941.65
   Jungheim ES, 2011, FERTIL STERIL, V95, P1970, DOI 10.1016/j.fertnstert.2011.01.154
   Kanungo J, 2011, OBSTET GYNECOL, V118, P872, DOI [10.1097/AOG.0b013e3182310c4c, 10.1097/AOG.0b013e31822add60]
   Kapadia MZ, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0132650
   Kiel DW, 2007, OBSTET GYNECOL, V110, P752, DOI 10.1097/01.AOG.0000278819.17190.87
   Kirkegaard H, 2014, AM J CLIN NUTR, V99, P312, DOI 10.3945/ajcn.113.067405
   Kirwan JP, 2002, DIABETES, V51, P2207, DOI 10.2337/diabetes.51.7.2207
   Knudsen VK, 2008, EUR J CLIN NUTR, V62, P463, DOI 10.1038/sj.ejcn.1602745
   Knudsen VK, 2013, BRIT J NUTR, V109, P1471, DOI 10.1017/S0007114512003443
   Koren O, 2012, CELL, V150, P470, DOI 10.1016/j.cell.2012.07.008
   La Vignera S, 2011, EUR REV MED PHARMACO, V15, P267
   Larsen TB, 2007, THROMB RES, V120, P505, DOI 10.1016/j.thromres.2006.12.003
   Lassance L, 2015, AM J OBSTET GYNECOL, V212, DOI 10.1016/j.ajog.2015.02.026
   Lassance L, 2015, J CLIN ENDOCR METAB, V100, pE11, DOI 10.1210/jc.2014-2792
   Lawlor DA, 2007, AM J EPIDEMIOL, V165, P418, DOI 10.1093/aje/kwk030
   Leermakers ETM, 2017, CLIN NUTR, V36, P477, DOI 10.1016/j.clnu.2015.12.017
   Lemas DJ, 2015, INT J OBESITY, V39, P1437, DOI 10.1038/ijo.2015.109
   Lemas DJ, 2016, AM J CLIN NUTR, V103, P1291, DOI 10.3945/ajcn.115.126375
   Lindholm ES, 2013, PROSTAG LEUKOTR ESS, V88, P211, DOI 10.1016/j.plefa.2012.11.007
   Lindsay CA, 1997, OBSTET GYNECOL, V89, P377, DOI 10.1016/S0029-7844(96)00517-0
   Lipsky LM, 2016, MATERN CHILD NUTR, V12, P569, DOI 10.1111/mcn.12149
   Lovelady CA, 2000, NEW ENGL J MED, V342, P449, DOI 10.1056/NEJM200002173420701
   Ludwig DS, 2013, PLOS MED, V10, DOI 10.1371/journal.pmed.1001521
   Luke B, 2011, HUM REPROD, V26, P245, DOI 10.1093/humrep/deq306
   Mackeen AD, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003577.pub3
   Magkos F, 2016, CELL METAB, V23, P591, DOI 10.1016/j.cmet.2016.02.005
   Makgoba M, 2012, BJOG-INT J OBSTET GY, V119, P276, DOI 10.1111/j.1471-0528.2011.03156.x
   Mamun AA, 2009, CIRCULATION, V119, P1720, DOI 10.1161/CIRCULATIONAHA.108.813436
   Maslova E, 2016, CLIN NUTR, V35, P475, DOI 10.1016/j.clnu.2015.03.018
   Metwally M, 2008, FERTIL STERIL, V90, P714, DOI 10.1016/j.fertnstert.2007.07.1290
   Mhyre JM, 2007, INT ANESTHESIOL CLIN, V45, P51, DOI 10.1097/AIA.0b013e31802b8a90
   Michels KB, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025254
   Moon RJ, 2013, J CLIN ENDOCR METAB, V98, P299, DOI 10.1210/jc.2012-2482
   Mostello D, 2010, OBSTET GYNECOL, V116, P667, DOI 10.1097/AOG.0b013e3181ed74ea
   Muktabhant B, 2015, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD007145.pub3
   Nascimento SL, 2014, INT J OBESITY, V38, P626, DOI 10.1038/ijo.2013.183
   NAUMANN RW, 1995, OBSTET GYNECOL, V85, P412, DOI 10.1016/0029-7844(94)00427-F
   Nohr EA, 2008, AM J CLIN NUTR, V87, P1750, DOI 10.1093/ajcn/87.6.1750
   Nuthalapaty FS, 2004, OBSTET GYNECOL, V103, P452
   O'Tierney-Ginn P, 2015, J CLIN ENDOCR METAB, V100, P159, DOI 10.1210/jc.2014-3281
   O'Tierney-Ginn P, 2014, AM J OBSTET GYNECOL, V211, DOI 10.1016/j.ajog.2014.05.031
   O'Toole ML, 2003, J WOMENS HEALTH, V12, P991, DOI 10.1089/154099903322643910
   Ogden CL, 2014, JAMA-J AM MED ASSOC, V311, P806, DOI 10.1001/jama.2014.732
   Oken E, 2007, AM J OBSTET GYNECOL, V196, DOI 10.1016/j.ajog.2006.11.027
   Oken E, 2009, AM J EPIDEMIOL, V170, P173, DOI 10.1093/aje/kwp101
   Phelan S, 2014, AM J CLIN NUTR, V99, P302, DOI 10.3945/ajcn.113.070151
   Poston L, 2015, LANCET DIABETES ENDO, V3, P767, DOI 10.1016/S2213-8587(15)00227-2
   Quinlivan JA, 2011, OBSTET GYNECOL, V118, P1395, DOI 10.1097/AOG.0b013e3182396bc6
   Radaelli T, 2009, AM J OBSTET GYNECOL, V201, DOI 10.1016/j.ajog.2009.04.019
   Ramsay JE, 2002, J CLIN ENDOCR METAB, V87, P4231, DOI 10.1210/jc.2002-020311
   Rasmussen KM, 2009, WEIGHT GAIN DURING PREGNANCY: REEXAMINING THE GUIDELINES, P1
   Reilly JJ, 2005, BMJ-BRIT MED J, V330, P1357, DOI 10.1136/bmj.38470.670903.E0
   Renault KM, 2015, AM J CLIN NUTR, V102, P1475, DOI 10.3945/ajcn.115.110551
   Renault KM, 2014, AM J OBSTET GYNECOL, V210, DOI 10.1016/j.ajog.2013.09.029
   Reynolds RM, 2010, J CLIN ENDOCR METAB, V95, P5365, DOI 10.1210/jc.2010-0697
   Roberts VHJ, 2009, PLACENTA, V30, P169, DOI 10.1016/j.placenta.2008.11.019
   Rodríguez-Bernal CL, 2010, AM J CLIN NUTR, V91, P1659, DOI 10.3945/ajcn.2009.28866
   Rohrer F., 1921, Munch Med Wochensch, V68, P580
   Rönö K, 2014, BMC PREGNANCY CHILDB, V14, DOI 10.1186/1471-2393-14-70
   Rudolph MC, 2017, INT J OBESITY, V41, P510, DOI 10.1038/ijo.2016.211
   RYAN EA, 1985, DIABETES, V34, P380, DOI 10.2337/diabetes.34.4.380
   Ryckman KK, 2016, AJP REP, V6, pE329, DOI 10.1055/s-0036-1592414
   Saben J, 2014, PLACENTA, V35, P171, DOI 10.1016/j.placenta.2014.01.003
   Saben JL, 2016, CELL REP, V16, P1, DOI 10.1016/j.celrep.2016.05.065
   Sagedal LR, 2017, BJOG-INT J OBSTET GY, V124, P97, DOI 10.1111/1471-0528.13862
   Santoro N, 2004, J CLIN ENDOCR METAB, V89, P2622, DOI 10.1210/jc.2003-031578
   Sattar N, 1998, INT J OBESITY, V22, P432, DOI 10.1038/sj.ijo.0800604
   Scifres CM, 2011, AM J OBSTET GYNECOL, V205, DOI 10.1016/j.ajog.2011.06.038
   Scifres CM, 2011, J CLIN ENDOCR METAB, V96, pE1083, DOI 10.1210/jc.2010-2084
   Sewell MF, 2006, AM J OBSTET GYNECOL, V195, P1100, DOI 10.1016/j.ajog.2006.06.014
   Shankar K, 2011, ENDOCRINOLOGY, V152, P4158, DOI 10.1210/en.2010-1078
   Shapiro ALB, 2016, INT J OBESITY, V40, P1056, DOI 10.1038/ijo.2016.79
   Sohlberg S, 2012, AM J HYPERTENS, V25, P120, DOI 10.1038/ajh.2011.175
   Soubry A, 2015, INT J OBESITY, V39, P650, DOI 10.1038/ijo.2013.193
   Starling AP, 2015, AM J CLIN NUTR, V101, P302, DOI 10.3945/ajcn.114.094946
   Stendell-Hollis NR, 2013, J WOMENS HEALTH, V22, P48, DOI 10.1089/jwh.2012.3707
   Stothard KJ, 2009, JAMA-J AM MED ASSOC, V301, P636, DOI 10.1001/jama.2009.113
   Streuling I, 2011, BJOG-INT J OBSTET GY, V118, P278, DOI 10.1111/j.1471-0528.2010.02801.x
   Tanentsapf I, 2011, BMC PREGNANCY CHILDB, V11, DOI 10.1186/1471-2393-11-81
   Thakali KM, 2014, PEDIATR RES, V76, P202, DOI 10.1038/pr.2014.72
   Thangaratinam S, 2012, BMJ-BRIT MED J, V344, DOI 10.1136/bmj.e2088
   Thangaratinam S, 2010, BJOG-INT J OBSTET GY, V117, P1309, DOI 10.1111/j.1471-0528.2010.02670.x
   Thomas DM, 2012, AM J CLIN NUTR, V95, P115, DOI 10.3945/ajcn.111.024307
   Tielemans MJ, 2016, AM J CLIN NUTR, V103, P83, DOI 10.3945/ajcn.115.110742
   Tsyvian PB, 2015, J DEV ORIG HLTH DIS, V6, P278, DOI 10.1017/S2040174415001117
   Turnbaugh PJ, 2009, J PHYSIOL-LONDON, V587, P4153, DOI 10.1113/jphysiol.2009.174136
   Valckx SDM, 2014, REPROD BIOL ENDOCRIN, V12, DOI 10.1186/1477-7827-12-13
   van den Broek M, 2015, AM J CLIN NUTR, V102, P873, DOI 10.3945/ajcn.114.102905
   Verdam FJ, 2013, OBESITY, V21, pE607, DOI 10.1002/oby.20466
   Vinter CA, 2011, DIABETES CARE, V34, P2502, DOI 10.2337/dc11-1150
   von Ungern-Sternberg BS, 2004, ANAESTHESIA, V59, P743, DOI 10.1111/j.1365-2044.2004.03832.x
   Vricella LK, 2011, AM J OBSTET GYNECOL, V205, DOI 10.1016/j.ajog.2011.06.085
   Wallace JM, 2014, BMC PREGNANCY CHILDB, V14, DOI 10.1186/1471-2393-14-40
   Walsh JM, 2012, BMJ-BRIT MED J, V345, DOI 10.1136/bmj.e5605
   Walter JR, 2015, AM J OBSTET GYNECOL, V212, DOI 10.1016/j.ajog.2014.11.012
   Waterland RA, 2014, ANNU REV NUTR, V34, P337, DOI 10.1146/annurev-nutr-071813-105315
   Waterland RA, 2010, PLOS GENET, V6, DOI 10.1371/journal.pgen.1001252
   Waters TP, 2012, J CLIN ENDOCR METAB, V97, P3648, DOI 10.1210/jc.2012-1781
   Whitaker RC, 1997, NEW ENGL J MED, V337, P869, DOI 10.1056/NEJM199709253371301
   Whitaker RC, 2004, PEDIATRICS, V114, pE29, DOI 10.1542/peds.114.1.e29
   Wloch C, 2012, BJOG-INT J OBSTET GY, V119, P1324, DOI 10.1111/j.1471-0528.2012.03452.x
   World Health Organization, 2000, WHO TECHN REP SER, V894
   Yin J, 2012, EUR J CLIN NUTR, V66, P1329, DOI 10.1038/ejcn.2012.122
   Yu ZB, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061627
NR 193
TC 711
Z9 768
U1 14
U2 186
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0959-535X
EI 1756-1833
J9 BMJ-BRIT MED J
JI BMJ-British Medical Journal
PD FEB 8
PY 2017
VL 356
AR j1
DI 10.1136/bmj.j1
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EL4FX
UT WOS:000394578200002
PM 28179267
OA Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Liu, ML
   Park, S
AF Liu, Meiling
   Park, Sunmin
TI A Causal Relationship between Vitamin C Intake with Hyperglycemia and
   Metabolic Syndrome Risk: A Two-Sample Mendelian Randomization Study
SO ANTIOXIDANTS
LA English
DT Article
DE vitamin C; metabolic syndrome; hyperglycemia; hypertension; type 2
   diabetes; Mendelian randomization
ID OXIDATIVE STRESS; ASSOCIATION; DISEASE; HEALTH
AB Excessive oxidative stress can contribute to metabolic syndrome (MetS), and antioxidants can protect against its development. Vitamin C (VC) is a well-known antioxidant, and observational studies have associated a deficiency with an increased MetS risk. This study tested the hypothesis that dietary VC intake caused an inverse relation of MetS and its components risk using a two-sample Mendelian randomization (MR) method in adults >= 40 years in a city hospital-based (n = 58,701) and Ansan/Ansung plus rural (n = 13,598) cohorts. Independent genetic variants associated with dietary VC intake were explored using a genome-wide association study (GWAS) with significance levels of p < 5 x 10(-5) and linkage disequilibrium (r2 threshold of 0.001), after adjusting for the covariates related to MetS, in a city hospital-based cohort (n = 52,676) excluding the participants having vitamin supplementation. MR methods, including inverse-variance weighting (IVW), weighted median, MR-Egger, and weighted model, were used to determine the causal relationship between the dietary VC intake and the risk of MetS and its components in Ansan/Ansung plus rural cohorts (n = 11,733). Heterogeneity and leave-one-out sensitivity analyses were conducted. Energy intake, as well as other nutrient intakes, were significantly lower in the low VC intake group than in the high VC intake group, but the incidence of MetS and its components, including hyperglycemia, hypertriglyceridemia, and hypertension, was observationally higher in inadequate low VC intake in the combined cohorts. In MR analysis, insufficient dietary VC intake increased the risk of MetS, hyperglycemia, hypertriglyceridemia, and hypertension in an IVW (p < 0.05). In contrast, only the serum fasting blood glucose concentration was significantly associated with VC intake in weight median analysis (p < 0.05), but there was no significant association of low dietary VC with MetS and its components in MR-Egger. There was no likelihood of heterogeneity and horizontal pleiotropy in MetS and its components. A single genetic variant did not affect their association in the leave-one-out sensitivity analysis. In conclusion, insufficient dietary VC intake potentially increased the MetS and hyperglycemia risk in Asian adults. Low VC intake can contribute to increasing type 2 diabetes incidence in Asians.
C1 [Liu, Meiling; Park, Sunmin] Hoseo Univ, Obes Diabet Res Ctr, Dept Food & Nutr, Asan 31499, South Korea.
C3 Hoseo University
RP Park, S (corresponding author), Hoseo Univ, Obes Diabet Res Ctr, Dept Food & Nutr, Asan 31499, South Korea.
EM 20185752@vision.hoseo.edu; smpark@hoseo.edu
OI Park, Sunmin/0000-0002-6092-8340
FU National Research Foundation of Korea [2019R1A2C1007203]
FX This research was supported by the National Research Foundation of Korea
   (2019R1A2C1007203).
CR Ahn Y, 2007, EUR J CLIN NUTR, V61, P1435, DOI 10.1038/sj.ejcn.1602657
   Al Nahdi AMT, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/7054272
   Baumeister SE, 2021, ADDICT BIOL, V26, DOI 10.1111/adb.13020
   Card D.J., 2019, LAB ASSESSMENT VITAM, P301, DOI 10.1016/B978-0-12-813050-6.00013-9
   Carr AC, 2020, NUTRIENTS, V12, DOI 10.3390/nu12071963
   Cheng L, 2019, FRONT GENET, V10, DOI 10.3389/fgene.2019.00094
   Dakhale GN, 2011, ADV PHARMACOL SCI, V2011, DOI 10.1155/2011/195271
   Dehghan M, 2007, NUTR J, V6, DOI 10.1186/1475-2891-6-41
   Di Francesco S, 2017, HORM METAB RES, V49, P507, DOI 10.1055/s-0043-109866
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Guo HB, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.728880
   Harroud A, 2018, MULT SCLER J, V24, P80, DOI 10.1177/1352458517737373
   Hirschhorn JN, 2005, NAT REV GENET, V6, P95, DOI 10.1038/nrg1521
   Hong KW, 2018, NUTR RES, V51, P82, DOI 10.1016/j.nutres.2017.12.012
   Huang GW, 2021, BMC RHEUMATOL, V5, DOI 10.1186/s41927-021-00216-0
   Hurrle S, 2017, BIOMED J, V40, P257, DOI 10.1016/j.bj.2017.06.007
   Ipsen DH, 2014, NUTRIENTS, V6, P5473, DOI 10.3390/nu6125473
   Kim J.Y., 2018, KOREAN J FAMILY PRAC, V8, P113, DOI [10.21215/kjfp.2018.8.1.113, DOI 10.21215/KJFP.2018.8.1.113]
   Kim Y, 2017, INT J EPIDEMIOL, V46, P1350, DOI 10.1093/ije/dyx105
   Kim YoungNam Kim YoungNam, 2017, Korean Journal of Community Nutrition, V22, P279, DOI 10.5720/kjcn.2017.22.4.279
   Kiuch S., 2021, INT J ANAL BIOSCI, V9, P1
   Lee YH, 2020, J RHEUMAT DIS, V27, P241, DOI 10.4078/jrd.2020.27.4.241
   Liu JQ, 2019, CANCER MED-US, V8, P1817, DOI 10.1002/cam4.2018
   Mason SA, 2021, DIABETES CARE, V44, P618, DOI 10.2337/dc20-1893
   Park S, 2021, AM J CLIN NUTR, V113, P1023, DOI 10.1093/ajcn/nqaa379
   Park S, 2020, ASMC PROC
   Park S, 2021, CLIN NUTR, V40, P5355, DOI 10.1016/j.clnu.2021.09.003
   Park S, 2021, NUTRIENTS, V13, DOI 10.3390/nu13082849
   Park S, 2021, NUTRIENTS, V13, DOI 10.3390/nu13041312
   Park S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12102912
   Park S, 2018, ALCOHOL CLIN EXP RES, V42, P2326, DOI 10.1111/acer.13888
   Park S, 2016, CLIN NUTR, V35, P1159, DOI 10.1016/j.clnu.2015.09.010
   Park S, 2015, J KOREAN MED SCI, V30, P1279, DOI 10.3346/jkms.2015.30.9.1279
   Park S, 2015, NUTRITION, V31, P111, DOI 10.1016/j.nut.2014.05.011
   Peters T, 2020, FRONT GENET, V11, DOI 10.3389/fgene.2020.00373
   Praveen D, 2020, FUTUR J PHARM SCI, V6, DOI 10.1186/s43094-020-00040-2
   Rabbee N, 2006, BIOINFORMATICS, V22, P7, DOI 10.1093/bioinformatics/bti741
   Ran L, 2020, CARDIOVASC THER, V2020, DOI 10.1155/2020/4940673
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   Shimobayashi M, 2018, J CLIN INVEST, V128, P1538, DOI 10.1172/JCI96139
   Tangvarasittichai S, 2015, WORLD J DIABETES, V6, P456, DOI 10.4239/wjd.v6.i3.456
   VERA JC, 1993, NATURE, V364, P79, DOI 10.1038/364079a0
   Wong SK, 2020, INT J MED SCI, V17, P1625, DOI 10.7150/ijms.47103
   Wootton RE, 2018, BMJ-BRIT MED J, V362, DOI 10.1136/bmj.k3788
   Yang HJ, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10050756
   Zatterale F, 2020, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.01607
   Zheng JS, 2021, DIABETES CARE, V44, P98, DOI 10.2337/dc20-1328
NR 47
TC 17
Z9 17
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAY
PY 2022
VL 11
IS 5
AR 857
DI 10.3390/antiox11050857
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 1P2XK
UT WOS:000801877800001
PM 35624721
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bartoli, F
   Crocamo, C
   Bava, M
   Castagna, G
   Di Brita, C
   Riboldi, I
   Trotta, G
   Verrengia, E
   Clerici, M
   Carrá, G
AF Bartoli, Francesco
   Crocamo, Cristina
   Bava, Mattia
   Castagna, Gloria
   Di Brita, Carmen
   Riboldi, Ilaria
   Trotta, Giulia
   Verrengia, Enrica
   Clerici, Massimo
   Carra, Giuseppe
TI Testing the association of serum uric acid levels with behavioral and
   clinical characteristics in subjects with major affective disorders: A
   cross-sectional study
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Behavior; Bipolar disorder; Major depression; Uric acid
ID BIPOLAR DISORDER; METABOLIC SYNDROME; DEPRESSIVE DISORDER; OXIDATIVE
   STRESS; METAANALYSIS; RISK; ALLOPURINOL; AGGRESSION; SEVERITY; HISTORY
AB Previous research has hypothesized a role for serum uric acid as a marker of mental disorders and related behaviors, possibly due to its link with purinergic transmission and antioxidant activity. We tested the association of serum uric acid levels with specific behavioral and clinical characteristics in 99 individuals suffering from major affective disorders. Subjects were assessed and interviewed using the Kessler Psychological Distress Scale, the Columbia-Suicide Severity Rating Scale, the Modified Overt Aggression Scale, and the Barratt Impulsiveness Scale. We found that psychological distress and suicidal ideation severity were associated with lower uric acid serum levels. On the other hand, verbal aggression and history of violence were associated with higher levels of serum uric acid. However, according to linear regression analyses, there were no behavioral and clinical characteristics independently associated with serum uric acid. Serum uric acid levels were influenced by creatinine and BMI, as well as, possibly, by white blood cells count and gender. Despite some limitations, these results suggest that no behavioral / clinical features are associated with variations of serum uric acid, which rather seem attributable to specific biochemical and metabolic parameters. Nevertheless, the role of purinergic system in different mental disorders and behavioral abnormalities, deserves further research.
C1 [Bartoli, Francesco; Crocamo, Cristina; Bava, Mattia; Castagna, Gloria; Di Brita, Carmen; Riboldi, Ilaria; Trotta, Giulia; Verrengia, Enrica; Clerici, Massimo; Carra, Giuseppe] Univ Milano Bicocca, Dept Med & Surg, Via Cadore 48, I-20900 Monza, Italy.
   [Carra, Giuseppe] UCL, Div Psychiat, 6th Floor,Maple House,149 Tottenham Court Rd, London W1T 7NF, England.
C3 University of Milano-Bicocca; University of London; University College
   London
RP Bartoli, F (corresponding author), Univ Milano Bicocca, Dept Med & Surg, Via Cadore 48, I-20900 Monza, Italy.
EM f.bartoli@campus.unimib.it
RI Crocamo, Cristina/I-4355-2019; Riboldi, Ilaria/ABF-5800-2020; Clerici,
   Massimo/U-3074-2019; Carra, Giuseppe/C-6091-2012; Bartoli,
   Francesco/K-5755-2016; Dakanalis Antonios Ntakanales, MD, MSc, PsyD,
   PhD, FNASc, Antonios/I-5105-2013; Crocamo, Cristina/B-5404-2014
OI Carra, Giuseppe/0000-0002-6877-6169; Bartoli,
   Francesco/0000-0003-2612-4119; Dakanalis Antonios Ntakanales, MD, MSc,
   PsyD, PhD, FNASc, Antonios/0000-0002-2328-3862; Clerici,
   Massimo/0000-0001-8769-6474; Riboldi, Ilaria/0000-0002-8188-800X;
   Crocamo, Cristina/0000-0002-2979-2107
CR Albert U, 2015, J AFFECT DISORDERS, V173, P170, DOI 10.1016/j.jad.2014.11.005
   Bartoli F, 2018, GEN HOSP PSYCHIAT, V51, P128, DOI 10.1016/j.genhosppsych.2017.09.002
   Bartoli F, 2018, EUR ARCH PSY CLIN N, V268, P119, DOI 10.1007/s00406-017-0817-7
   Bartoli F, 2017, COMPR PSYCHIAT, V73, P1, DOI 10.1016/j.comppsych.2016.09.011
   Bartoli F, 2017, BRIT J PSYCHIAT, V210, P10, DOI 10.1192/bjp.bp.115.180281
   Bartoli F, 2016, J PSYCHIATR RES, V81, P133, DOI 10.1016/j.jpsychires.2016.07.007
   Bartoli F, 2016, J PSYCHOSOM RES, V84, P56, DOI 10.1016/j.jpsychores.2016.03.014
   Biancosino B, 2009, J NERV MENT DIS, V197, P772, DOI 10.1097/NMD.0b013e3181bb0d6b
   Black CN, 2018, J AFFECT DISORDERS, V225, P684, DOI 10.1016/j.jad.2017.09.003
   Bowman GL, 2010, J ALZHEIMERS DIS, V19, P1331, DOI 10.3233/JAD-2010-1330
   Carr CN, 2017, PHARMACOTHERAPY, V37, P748, DOI 10.1002/phar.1943
   Carrà G, 2011, EUR PSYCHIAT, V26, P122, DOI 10.1016/j.eurpsy.2010.04.008
   Cheffer A, 2018, MOL PSYCHIATR, V23, P94, DOI 10.1038/mp.2017.188
   Chiu CC, 2012, J CLIN PSYCHOPHARM, V32, P585, DOI 10.1097/JCP.0b013e3182664e64
   Clerici M, 2014, GEN HOSP PSYCHIAT, V36, P698, DOI 10.1016/j.genhosppsych.2014.08.005
   Cooke AA, 2016, EUR J PHARMACOL, V785, P207, DOI 10.1016/j.ejphar.2016.04.021
   Daskalopoulou SS, 2005, CURR PHARM DESIGN, V11, P4161, DOI 10.2174/138161205774913309
   de Girolamo G, 2016, J PSYCHIATR RES, V80, P5, DOI 10.1016/j.jpsychires.2016.05.010
   de Oliveira EP, 2012, DIABETOL METAB SYNDR, V4, DOI 10.1186/1758-5996-4-12
   Desideri G, 2014, EUR REV MED PHARMACO, V18, P1295
   Feig DI, 2008, NEW ENGL J MED, V359, P1811, DOI 10.1056/NEJMra0800885
   Fossati A, 2001, J CLIN PSYCHOL, V57, P815, DOI 10.1002/jclp.1051
   Gluba A, 2013, INT J CARDIOL, V164, P141, DOI 10.1016/j.ijcard.2012.01.013
   Grioni S, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0126550
   Haghighi M, 2016, PSYCHIAT RES, V235, P49, DOI 10.1016/j.psychres.2015.12.002
   Jiménez-Fernández S, 2015, J CLIN PSYCHIAT, V76, P1658, DOI 10.4088/JCP.14r09179
   Keller KB, 2003, AM J CRIT CARE, V12, P167, DOI 10.4037/ajcc2003.12.2.167
   Lindberg D, 2015, CURR MOL MED, V15, P275, DOI 10.2174/1566524015666150330163724
   Lu WJ, 2015, SCI REP-UK, V5, DOI 10.1038/srep12144
   Maiuolo J, 2016, INT J CARDIOL, V213, P8, DOI 10.1016/j.ijcard.2015.08.109
   Margari F, 2005, INT J METH PSYCH RES, V14, P109, DOI 10.1002/mpr.22
   Mrug S, 2016, PHYSIOL BEHAV, V163, P144, DOI 10.1016/j.physbeh.2016.05.014
   Nurmedov S, 2016, KLIN PSIKOFARMAKOL B, V26, P223, DOI 10.5455/bcp.20160222092414
   Ortiz R, 2015, PROG NEURO-PSYCHOPH, V57, P117, DOI 10.1016/j.pnpbp.2014.10.016
   Peng YF, 2016, SCI REP-UK, V6, DOI 10.1038/srep34402
   Posner K, 2011, AM J PSYCHIAT, V168, P1266, DOI 10.1176/appi.ajp.2011.10111704
   Ruggiero C, 2006, EUR HEART J, V27, P1174, DOI 10.1093/eurheatj/ehi879
   SPITZ RT, 1995, PSYCHOL REP, V76, P130, DOI 10.2466/pr0.1995.76.1.130
   Sutin AR, 2014, BIOL PSYCHIAT, V75, P31, DOI 10.1016/j.biopsych.2013.02.024
   Vargas HO, 2013, J AFFECT DISORDERS, V150, P923, DOI 10.1016/j.jad.2013.05.016
   von Elm E, 2008, J CLIN EPIDEMIOL, V61, P344, DOI 10.2471/BLT.07.045120
   Yuan HP, 2015, J CLIN ENDOCR METAB, V100, P4198, DOI 10.1210/jc.2015-2527
NR 42
TC 13
Z9 13
U1 2
U2 13
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD NOV
PY 2018
VL 269
BP 118
EP 123
DI 10.1016/j.psychres.2018.08.039
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HA0MS
UT WOS:000449902700020
PM 30145291
DA 2025-06-11
ER

PT J
AU Askin, L
   Uzel, KE
   Tanriverdi, O
   Turkmen, S
AF Askin, Lutfu
   Uzel, Kader Eliz
   Tanriverdi, Okan
   Turkmen, Serdar
TI Serum Irisin: Pathogenesis and Clinical Research in Cardiovascular
   Diseases
SO CARDIOVASCULAR INNOVATIONS AND APPLICATIONS
LA English
DT Review
DE insulin resistance; irisin; cardiovascular diseases; body mass index
ID TYPE-2 DIABETES-MELLITUS; MYOCARDIAL-INFARCTION; ASSOCIATION;
   ADIPOCYTES; HEALTHY; MYOKINE; MARKER; INJURY
AB Recently, muscular function/dysfunction has gained importance in the maintenance of metabolic homeostasis in cardiovascular diseases. Skeletal muscle plays a vital role in coordinating the activity and metabolism of endocrine organs by secreting many myokines, especially irisin. Irisin is a polypeptide hormone consisting of 112 amino acids secreted into the blood from muscle and adipose tissues. Serum irisin levels are associated with cardiometabolic risk factors such as obesity and insulin resistance as defined by homeostatic model assessment. Irisin reduces endothelial damage by inhibiting inflammation and oxidative stress, thus playing a key role in maintaining endothelial cell function. Unsurprisingly, low irisin levels cause endothelial dysfunction and increase the incidence of atherosclerosis. We aimed to summarize the studies on this issue since we have not found any review in the literature on the role of serum irisin levels in the process of atherosclerosis and other cardiovascular events in cardiovascular diseases.
C1 [Askin, Lutfu; Uzel, Kader Eliz; Tanriverdi, Okan; Turkmen, Serdar] Adiyaman Educ & Res Hosp, Dept Cardiol, TR-2230 Adiyaman, Turkey.
RP Askin, L (corresponding author), Adiyaman Educ & Res Hosp, Dept Cardiol, TR-2230 Adiyaman, Turkey.
EM lutfuaskin23@gmail.com
RI Türkmen, Serdar/ABF-8271-2021; Tanriverdi, Ozgur/M-2172-2015; askin,
   lutfu/H-1047-2018
OI askin, lutfu/0000-0001-7768-2562
CR Abd El-Mottaleb NA, 2019, CAN J PHYSIOL PHARM, V97, P932, DOI 10.1139/cjpp-2018-0736
   Alis R, 2014, CLIN BIOCHEM, V47, P333, DOI 10.1016/j.clinbiochem.2014.08.017
   American Diabetes Association, 2018, Clin Diabetes, V36, P14, DOI 10.2337/cd17-0119
   Aronis KN, 2015, INT J OBESITY, V39, P156, DOI 10.1038/ijo.2014.101
   Asadi Y, 2018, NEUROCHEM RES, V43, P1549, DOI 10.1007/s11064-018-2569-9
   Ates I, 2017, Endocr Regul, V51, P1, DOI 10.1515/enr-2017-0001
   Aydin S, 2016, BIOTECH HISTOCHEM, V91, P242, DOI 10.3109/10520295.2015.1136988
   Aydin S, 2014, PEPTIDES, V56, P141, DOI 10.1016/j.peptides.2014.04.002
   Bashar Shaimaa M., 2019, Journal of Basic and Clinical Physiology and Pharmacology, V30, P59, DOI 10.1515/jbcpp-2018-0090
   Bi JB, 2019, REDOX BIOL, V20, P296, DOI 10.1016/j.redox.2018.10.019
   Boström P, 2012, NATURE, V481, P463, DOI 10.1038/nature10777
   Cai CB, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-08406-y
   Calan M, 2019, HORM-INT J ENDOCRINO, V18, P435, DOI 10.1007/s42000-019-00151-3
   Chen JQ, 2015, LIPIDS HEALTH DIS, V14, DOI 10.1186/1476-511X-14-2
   Chen N, 2016, DIABETES-METAB RES, V32, P51, DOI 10.1002/dmrr.2660
   Chen RR, 2019, CHEM-BIOL INTERACT, V302, P11, DOI 10.1016/j.cbi.2019.01.031
   De Meneck F, 2018, NUTR METAB CARDIOVAS, V28, P756, DOI 10.1016/j.numecd.2018.04.009
   Deng W, 2016, MED SCI MONITOR, V22, P4193, DOI 10.12659/MSM.897376
   Elizondo-Montemayor L, 2019, MEDIAT INFLAMM, V2019, DOI 10.1155/2019/6737318
   Elizondo-Montemayor L, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19123727
   Emanuele E, 2014, AM J MED, V127, P888, DOI 10.1016/j.amjmed.2014.04.025
   Fan JM, 2020, J CELL PHYSIOL, V235, P1165, DOI 10.1002/jcp.29030
   Gür FM, 2017, BIOTECH HISTOCHEM, V92, P245, DOI 10.1080/10520295.2017.1303194
   He L, 2018, KIDNEY BLOOD PRESS R, V43, P287, DOI 10.1159/000487689
   Hisamatsu T, 2018, INT J CARDIOL, V267, P177, DOI 10.1016/j.ijcard.2018.05.075
   Ho MY, 2018, BIOCHEM BIOPH RES CO, V503, P2493, DOI 10.1016/j.bbrc.2018.07.005
   Hsieh IC, 2018, INT J CARDIOL, V261, P12, DOI 10.1016/j.ijcard.2017.11.072
   Kalkan AK, 2018, ARQ BRAS CARDIOL, V111, P39, DOI 10.5935/abc.20180109
   Khidr EG, 2017, GENE, V626, P26, DOI 10.1016/j.gene.2017.05.010
   Khorasani ZM, 2019, DIABETES METAB SYND, V13, P786, DOI 10.1016/j.dsx.2018.11.050
   Kuloglu T, 2014, PEPTIDES, V55, P85, DOI 10.1016/j.peptides.2014.02.008
   Li Z, 2017, BIOSCIENCE REP, V37, DOI 10.1042/BSR20170213
   Lu JY, 2015, ATHEROSCLEROSIS, V243, P438, DOI 10.1016/j.atherosclerosis.2015.10.020
   Melmed S., 2015, Williams textbook of endocrinology
   Mirzaei K, 2013, DIABETOL METAB SYNDR, V5, DOI 10.1186/1758-5996-5-79
   Moreno M, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0124100
   Moreno-Perez O, 2018, CLIN ENDOCRINOL, V89, P414, DOI 10.1111/cen.13800
   Rosen ED, 2006, NATURE, V444, P847, DOI 10.1038/nature05483
   Shen ST, 2017, CELL PHYSIOL BIOCHEM, V42, P615, DOI 10.1159/000477867
   Shim YS, 2018, ENDOCR J, V65, P23, DOI 10.1507/endocrj.EJ17-0260
   Tu WJ, 2018, NEUROTHERAPEUTICS, V15, P1158, DOI 10.1007/s13311-018-0651-2
   Vamvini MT, 2013, EUR J ENDOCRINOL, V169, P829, DOI 10.1530/EJE-13-0276
   Yan Bing, 2014, PLoS One, V9, pe94235, DOI 10.1371/journal.pone.0094235
   Yu Q, 2019, CLIN SCI, V133, P611, DOI 10.1042/CS20190016
   Zhang M, 2014, EUR REV MED PHARMACO, V18, P1567
   Zhang Y, 2014, DIABETES, V63, P514, DOI 10.2337/db13-1106
   Zhang YZ, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0158038
   Zhou X, 2019, CELL BIOSCI, V9, DOI 10.1186/s13578-019-0294-y
   Zhu D, 2015, J MOL CELL CARDIOL, V87, P138, DOI 10.1016/j.yjmcc.2015.07.015
NR 49
TC 5
Z9 5
U1 0
U2 10
PU COMPUSCRIPT
PI SHANNON
PA BAY 11A, SHANNON INDUSTRIAL EST, SHANNON, CLARE 00000, IRELAND
SN 2009-8618
EI 2009-8782
J9 CARDIOVASC INNOV APP
JI Cardiovasc. Innov. Appl.
PD JAN 1
PY 2020
VL 4
IS 3
BP 195
EP 200
DI 10.15212/CVIA.2019.0569
PG 6
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA KY5SH
UT WOS:000522631900005
OA gold
DA 2025-06-11
ER

PT J
AU Vijayan, M
   Reddy, PH
AF Vijayan, Murali
   Reddy, P. Hemachandra
TI Peripheral biomarkers of stroke: Focus on circulatory microRNAs
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Review
DE Stroke; Vascular dementia; Alzheimer's disease; Circulatory microRNA;
   Serum; Plasma; Protein biomarker
ID C-REACTIVE PROTEIN; TRANSIENT ISCHEMIC ATTACK; PHOSPHOLIPASE A(2);
   INFARCT VOLUME; BIOCHEMICAL MARKERS; HEART-DISEASE; SERUM S100B; RISK;
   BRAIN; EXPRESSION
AB Stroke is the second leading cause of death in the world. Stroke occurs when blood flow stops, and that stoppage results in reduced oxygen supply to neurons in the brain. The occurrence of stroke increases with age, but anyone at any age can suffer from stroke. Recent research has implicated multiple cellular changes in stroke patients, including oxidative stress and mitochondrial dysfunction, inflammatory responses, and changes in mRNA and proteins. Recent research has also revealed that stroke is associated with modifiable and non-modifiable risk factors. Stroke can be controlled by modifiable risk factors, including diet, cardiovascular, hypertension, smoking, diabetes, obesity, metabolic syndrome, depression and traumatic brain injury. Stroke is the major risk factor for vascular dementia (VaD) and Alzheimer's disease (AD). The purpose of this article is to review the latest developments in research efforts directed at identifying 1) latest developments in identifying biomarkers in peripheral and central nervous system tissues, 2) changes in microRNAs (miRNAs) in patients with stroke, 3) miRNA profile and function in animal brain, and 4) protein biomarkers in ischemic stroke. This article also reviews research investigating circulatory miRNAs as peripheral biomarkers of stroke. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Vijayan, Murali; Reddy, P. Hemachandra] Texas Tech Univ, Garrison Inst Aging, Hlth Sci Ctr, 3601 4th St,MS 9424,4A 124, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Cell Biol & Biochem, Hlth Sci Ctr, 3601 4th St,MS 9424, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Neurosci & Pharmacol, Hlth Sci Ctr, 3601 4th St,MS 9424, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Neurol, Hlth Sci Ctr, 3601 4th St,MS 9424, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Speech Sci Dept, 3601 4th St,MS 9424, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Language & Hearing Sci Dept, 3601 4th St,MS 9424, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Garrison Inst Aging, South West Campus,6630 S Quaker Ste E,MS 7495, Lubbock, TX 79413 USA.
C3 Texas Tech University System; Texas Tech University Health Sciences
   Center Lubbock; Texas Tech University System; Texas Tech University
   Health Sciences Center Lubbock; Texas Tech University System; Texas Tech
   University Health Sciences Center Lubbock; Texas Tech University System;
   Texas Tech University Health Sciences Center Lubbock; Texas Tech
   University System; Texas Tech University Health Sciences Center Lubbock;
   Texas Tech University System; Texas Tech University Health Sciences
   Center Lubbock; Texas Tech University System; Texas Tech University
   Health Sciences Center Lubbock
RP Reddy, PH (corresponding author), Texas Tech Univ, Garrison Inst Aging, Hlth Sci Ctr, 3601 4th St,MS 9424,4A 124, Lubbock, TX 79430 USA.
EM hemachandra.reddy@ttuhsc.edu
FU National Institutes of Health [AG042178, AG47812]; Garrison Family
   Foundation
FX Work presented in this article is supported by National Institutes of
   Health grants - AG042178 and AG47812 and Garrison Family Foundation.
CR ADAMS HP, 1993, STROKE, V24, P35, DOI 10.1161/01.STR.24.1.35
   Ai J, 2013, J NEUROSCI, V33, P3989, DOI 10.1523/JNEUROSCI.1997-12.2013
   Allard L, 2004, PROTEOMICS, V4, P2242, DOI 10.1002/pmic.200300809
   Alvarez-Llamas G, 2008, EXPERT REV PROTEOMIC, V5, P679, DOI 10.1586/14789450.5.5.679
   Alvarez-Perez FJ, 2011, J NEUROL NEUROSUR PS, V82, P986, DOI 10.1136/jnnp.2010.230870
   Ambros V, 2001, CELL, V107, P823, DOI 10.1016/S0092-8674(01)00616-X
   [Anonymous], 2011, The Atlas of Heart Disease and Stroke. Part 2 Risk factors
   [Anonymous], GENE
   Arenillas JF, 2003, STROKE, V34, P2463, DOI 10.1161/01.STR.0000089920.93927.A7
   Ballantyne CM, 2005, ARCH INTERN MED, V165, P2479, DOI 10.1001/archinte.165.21.2479
   Banerjee Tapas Kumar, 2005, J Indian Med Assoc, V103, ppassim
   Bokhari Faraz Ahmed, 2014, J Ayub Med Coll Abbottabad, V26, P111
   Chaudhuri JR, 2013, IRAN J NEUROL, V12, P92
   Cheung EYL, 2008, STROKE, V39, P1033, DOI 10.1161/STROKEAHA.107.495499
   Chi WY, 2014, BRAIN RES, V1592, P22, DOI 10.1016/j.brainres.2014.09.072
   Chuang SY, 2009, STROKE, V40, P1578, DOI 10.1161/STROKEAHA.108.540492
   Curb JD, 2003, CIRCULATION, V107, P2016, DOI 10.1161/01.CIR.0000065228.20100.F7
   Dambinova SA, 2003, CLIN CHEM, V49, P1752, DOI 10.1373/49.10.1752
   Dambinova SA, 2002, STROKE, V33, P1181, DOI 10.1161/01.STR.0000014922.83673.86
   Danesh J, 2005, JAMA-J AM MED ASSOC, V294, P1799, DOI 10.1001/jama.294.14.1799
   Di Napoli M, 2005, STROKE, V36, P1316, DOI 10.1161/01.STR.0000165929.78756.ed
   Di Napoli M, 2001, STROKE, V32, P133, DOI 10.1161/01.STR.32.1.133
   Dichgans M, 2007, LANCET NEUROL, V6, P149, DOI 10.1016/S1474-4422(07)70028-5
   Elkind MSV, 2006, ARCH INTERN MED, V166, P2073, DOI 10.1001/archinte.166.19.2073
   Elkind MSV, 2009, CEREBROVASC DIS, V27, P42, DOI 10.1159/000172633
   Esquela-Kerscher A, 2006, NAT REV CANCER, V6, P259, DOI 10.1038/nrc1840
   Feigin VL, 2009, LANCET NEUROL, V8, P355, DOI 10.1016/S1474-4422(09)70025-0
   Foerch C, 2005, ARCH NEUROL-CHICAGO, V62, P1130, DOI 10.1001/archneur.62.7.1130
   Foerch C, 2004, STROKE, V35, P2160, DOI 10.1161/01.STR.0000138730.03264.ac
   Foerch C, 2007, STROKE, V38, P2491, DOI 10.1161/STROKEAHA.106.480111
   Gan CS, 2012, GENET MOL RES, V11, P147, DOI 10.4238/2012.January.27.1
   Greisenegger S, 2015, STROKE, V46, P659, DOI 10.1161/STROKEAHA.114.007624
   Harraz MM, 2012, P NATL ACAD SCI USA, V109, P18962, DOI 10.1073/pnas.1121288109
   Hassan A, 2000, BRAIN, V123, P1784, DOI 10.1093/brain/123.9.1784
   Henon H, 1997, STROKE, V28, P2429, DOI 10.1161/01.STR.28.12.2429
   Hill MD, 2000, CAN MED ASSOC J, V162, P1139
   Huang LG, 2015, CNS NEUROSCI THER, V21, P496, DOI 10.1111/cns.12383
   Jauch EC, 2006, STROKE, V37, P2508, DOI 10.1161/01.STR.0000242290.01174.9e
   Jickling GC, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0099283
   Lamers KJB, 2003, BRAIN RES BULL, V61, P261, DOI 10.1016/S0361-9230(03)00089-3
   LEE RC, 1993, CELL, V75, P843, DOI 10.1016/0092-8674(93)90529-Y
   Li JJ, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1002578
   Liu P, 2015, STROKE, V46, P513, DOI 10.1161/STROKEAHA.114.007482
   Liu YP, 2015, J CLIN NEUROSCI, V22, P291, DOI 10.1016/j.jocn.2014.05.042
   Long GW, 2013, BMC NEUROL, V13, DOI 10.1186/1471-2377-13-178
   Lopez MF, 2012, PROTEOM CLIN APPL, V6, P190, DOI 10.1002/prca.201100041
   Lozano R, 2012, LANCET, V380, P2095, DOI 10.1016/S0140-6736(12)61728-0
   Lüscher C, 2012, CSH PERSPECT BIOL, V4, DOI 10.1101/cshperspect.a005710
   Luna JM, 2014, STROKE, V45, P979, DOI 10.1161/STROKEAHA.113.002289
   Lynch JR, 2004, STROKE, V35, P57, DOI 10.1161/01.STR.0000105927.62344.4C
   Mauriello A, 2000, CIRCULATION, V101, P744, DOI 10.1161/01.CIR.101.7.744
   Montaner J, 2003, J CEREBR BLOOD F MET, V23, P1403, DOI 10.1097/01.WCB.0000100044.07481.97
   Murali V, 2016, INT J IMMUNOGENET, V43, P159, DOI 10.1111/iji.12266
   Murray CJL, 2012, LANCET, V380, P2197, DOI 10.1016/S0140-6736(12)61729-2
   Oei HHS, 2005, CIRCULATION, V111, P570, DOI 10.1161/01.CIR.0000154553.12214.CD
   Pang XM, 2015, J NEUROCHEM, V133, P926, DOI 10.1111/jnc.13094
   Polupanov AG, 2014, KARDIOLOGIYA, V54, P29
   Rosamond W, 2008, CIRCULATION, V117, pE25, DOI 10.1161/CIRCULATIONAHA.107.187998
   Rost NS, 2001, STROKE, V32, P2575, DOI 10.1161/hs1101.098151
   Rothwell PM, 2004, STROKE, V35, P2300, DOI 10.1161/01.STR.0000141701.36371.d1
   Selvamani A, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0032662
   Sepramaniam S, 2014, INT J MOL SCI, V15, P1418, DOI 10.3390/ijms15011418
   Shaafi S, 2014, IRAN J NEUROL, V13, P70
   Singh VK, 2014, INT J SCI STUDY, V2, P25
   Smith CJ, 2004, BMC NEUROL, V4, DOI 10.1186/1471-2377-4-2
   Sotgiu S, 2006, EUR J NEUROL, V13, P505, DOI 10.1111/j.1468-1331.2006.01280.x
   Sridharan SE, 2009, STROKE, V40, P1212, DOI 10.1161/STROKEAHA.108.531293
   Stanca DM, 2015, J CELL MOL MED, V19, P2253, DOI 10.1111/jcmm.12614
   Strong K, 2007, LANCET NEUROL, V6, P182, DOI 10.1016/S1474-4422(07)70031-5
   Sun Y, 2013, CNS NEUROSCI THER, V19, P813, DOI 10.1111/cns.12142
   Tan JR, 2013, INT J MOL SCI, V14, P2072, DOI 10.3390/ijms14012072
   Tan KS, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0007689
   Toledo JB, 2013, BRAIN, V136, P2697, DOI 10.1093/brain/awt188
   Towfighi A, 2010, STROKE, V41, P499, DOI 10.1161/STROKEAHA.109.571828
   Tuttolomondo A, 2008, CURR PHARM DESIGN, V14, P3574, DOI 10.2174/138161208786848739
   van Munster BC, 2009, BMC NEUROL, V9, DOI 10.1186/1471-2377-9-21
   Vemuganti R, 2013, NEUROCHEM INT, V63, P438, DOI 10.1016/j.neuint.2013.07.014
   Vemuganti R, 2010, TRANSL STROKE RES, V1, P158, DOI 10.1007/s12975-010-0030-8
   Vijayan M, 2014, META GENE, V2, P661, DOI 10.1016/j.mgene.2014.09.003
   Vila N, 2000, STROKE, V31, P2325, DOI 10.1161/01.STR.31.10.2325
   Vinciguerra A, 2014, MOL THER, V22, P1829, DOI 10.1038/mt.2014.113
   Wang WH, 2014, J STROKE CEREBROVASC, V23, P2607, DOI 10.1016/j.jstrokecerebrovasdis.2014.06.002
   Wassertheil-Smoller S, 2008, HYPERTENSION, V51, P1115, DOI 10.1161/HYPERTENSIONAHA.107.103721
   Weidhaas J, 2010, LANCET ONCOL, V11, P106, DOI 10.1016/S1470-2045(09)70386-9
   Woodruff TM, 2011, MOL NEURODEGENER, V6, DOI 10.1186/1750-1326-6-11
   Zeng Lili, 2011, Front Biosci (Elite Ed), V3, P1265
   Zhang Y, 2016, J AFFECT DISORDERS, V193, P51, DOI 10.1016/j.jad.2015.12.061
   Zhu F, 2014, J MOL NEUROSCI, V52, P148, DOI 10.1007/s12031-013-0155-9
   ,, 1988, Journal of Clinical Epidemiology, V41, P105, DOI 10.1016/0895-4356(88)90084-4
NR 89
TC 102
Z9 109
U1 0
U2 59
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD OCT
PY 2016
VL 1862
IS 10
BP 1984
EP 1993
DI 10.1016/j.bbadis.2016.08.003
PG 10
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA DU7RW
UT WOS:000382413300014
PM 27503360
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Allegrini, S
   Garcia-Gil, M
   Pesi, R
   Camici, M
   Tozzi, MG
AF Allegrini, Simone
   Garcia-Gil, Mercedes
   Pesi, Rossana
   Camici, Marcella
   Tozzi, Maria Grazia
TI The Good, the Bad and the New about Uric Acid in Cancer
SO CANCERS
LA English
DT Review
DE uric acid; hyperuricemia; oxidative stress; cancer; fructose; xanthine
   oxidoreductase; AKT; AMPK; mTOR; uricase
ID XANTHINE OXIDOREDUCTASE; MOLECULAR PHYSIOLOGY; METABOLIC SYNDROME;
   HEPATIC STEATOSIS; OXIDATIVE STRESS; PURINE SYNTHESIS; GENE-EXPRESSION;
   ADIPOSE-TISSUE; DANGER SIGNAL; URATE OXIDASE
AB Simple Summary The concentration of uric acid in blood is sex-, age- and diet-dependent and is maintained close to its maximal solubility, indicating that it plays some important role. Indeed, it has been demonstrated that, at physiological concentrations, uric acid is a powerful antioxidant and is a scavenger of singlet oxygen and radicals. At high intracellular concentration, uric acid has been demonstrated to act as a pro-oxidant molecule. Recently, uric acid has been reported to affect the properties of several proteins involved in metabolic regulation and signaling, and the relationship between uric acid and cancer has been extensively investigated. In this review, we present the most recent results on the positive and negative effects played by uric acid in cancer and some new findings and hypotheses about the implication of this metabolite in the pathogenesis of several diseases such as metabolic syndrome, diabetes, and inflammation, thus favoring the development of cancer. Uric acid is the final product of purine catabolism in man and apes. The serum concentration of uric acid is sex-, age- and diet-dependent and is maintained close to its maximal solubility, indicating that it plays some important role. Indeed, it has been demonstrated that, at physiological concentrations, uric acid is a powerful antioxidant, while at high intracellular concentrations, it is a pro-oxidant molecule. In this review, we describe the possible causes of uric acid accumulation or depletion and some of the metabolic and regulatory pathways it may impact. Particular attention has been given to fructose, which, because of the complex correlation between carbohydrate and nucleotide metabolism, causes uric acid accumulation. We also present recent results on the positive and negative effects played by uric acid in cancer and some new findings and hypotheses about the implication of this metabolite in a variety of signaling pathways, which can play a role in the pathogenesis of diseases such as metabolic syndrome, diabetes, and inflammation, thus favoring the development of cancer. The loss of uricase in Homo sapiens and great apes, although exposing these species to the potentially adverse effects of uric acid, appears to be associated with evolutionary advantages.
C1 [Allegrini, Simone; Pesi, Rossana; Camici, Marcella; Tozzi, Maria Grazia] Univ Pisa, Unita Biochim, Dipartimento Biol, Via San Zeno 51, I-56127 Pisa, Italy.
   [Allegrini, Simone; Garcia-Gil, Mercedes] Univ Pisa, Interdept Res Ctr Nutrafood Nutraceut & Food Hlth, I-56126 Pisa, Italy.
   [Allegrini, Simone; Garcia-Gil, Mercedes] Univ Pisa, CISUP, Ctr Integraz Strumentaz, I-56127 Pisa, Italy.
   [Garcia-Gil, Mercedes] Univ Pisa, Unita Fisiol Gen, Dipartimento Biol, Via San Zeno 31, I-56127 Pisa, Italy.
C3 University of Pisa; University of Pisa; University of Pisa; University
   of Pisa
RP Allegrini, S (corresponding author), Univ Pisa, Unita Biochim, Dipartimento Biol, Via San Zeno 51, I-56127 Pisa, Italy.; Allegrini, S (corresponding author), Univ Pisa, Interdept Res Ctr Nutrafood Nutraceut & Food Hlth, I-56126 Pisa, Italy.; Allegrini, S (corresponding author), Univ Pisa, CISUP, Ctr Integraz Strumentaz, I-56127 Pisa, Italy.
EM simone.allegrini@unipi.it
RI Pesi, Rossana/AAQ-3102-2020; Allegrini, Simone/F-9192-2010; TOZZI, MARIA
   GRAZIA/A-6018-2016
OI GARCIA GIL, MARIA de las MERCEDES/0000-0002-1344-2786; Allegrini,
   Simone/0000-0002-7005-654X; TOZZI, MARIA GRAZIA/0000-0002-1075-7096;
   Pesi, Rossana/0000-0003-4785-7282; CAMICI, MARCELLA/0000-0001-8133-8414
FU University of Pisa
FX This work was supported by local funding from the University of Pisa (ex
   60%) to S.A and M.G.-G.
CR Alvarez-Lario B, 2010, RHEUMATOLOGY, V49, P2010, DOI 10.1093/rheumatology/keq204
   AMES BN, 1981, P NATL ACAD SCI-BIOL, V78, P6858, DOI 10.1073/pnas.78.11.6858
   Aurilio G, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20225683
   Auscher C, 1979, Adv Exp Med Biol, V122B, P197
   Balestri F, 2022, BIOMOLECULES, V12, DOI 10.3390/biom12040485
   Battelli MG, 2019, REDOX BIOL, V21, DOI 10.1016/j.redox.2018.101070
   Battelli MG, 2016, CANCER MED-US, V5, P546, DOI 10.1002/cam4.601
   Battelli MG, 2014, BBA-MOL BASIS DIS, V1842, P1502, DOI 10.1016/j.bbadis.2014.05.022
   Blausen Medical, 2014, WikiJournal Med, V1, P1, DOI DOI 10.15347/WJM/2014.010
   Bobulescu A, 2012, ADV CHRONIC KIDNEY D, V19, P358, DOI 10.1053/j.ackd.2012.07.009
   Bortolotti M, 2021, REDOX BIOL, V41, DOI 10.1016/j.redox.2021.101882
   Camici M, 2018, FEBS J, V285, P3337, DOI 10.1111/febs.14508
   CAREY FG, 1961, BIOCHIM BIOPHYS ACTA, V53, P440, DOI 10.1016/0006-3002(61)90468-1
   Chaudhary K, 2013, CARDIORENAL MED, V3, P208, DOI 10.1159/000355405
   Chen HY, 2021, FRONT ONCOL, V11, DOI 10.3389/fonc.2021.631943
   Chen MM, 2022, ACTA PHARMACOL SIN, V43, P1623, DOI 10.1038/s41401-021-00800-7
   Chen M, 2018, ARTHRITIS RES THER, V20, DOI 10.1186/s13075-018-1512-4
   Cho SK, 2018, ARTHRITIS RHEUMATOL, V70, P1122, DOI 10.1002/art.40472
   Cicerchi C, 2014, FASEB J, V28, P3339, DOI 10.1096/fj.13-243634
   CLARE DA, 1981, ARCH BIOCHEM BIOPHYS, V211, P44, DOI 10.1016/0003-9861(81)90427-6
   Coutinho TD, 2007, AM J HYPERTENS, V20, P83, DOI 10.1016/j.amjhyper.2006.06.015
   Crawley WT, 2022, REDOX BIOL, V51, DOI 10.1016/j.redox.2022.102271
   Crisan TO, 2017, P NATL ACAD SCI USA, V114, P5485, DOI 10.1073/pnas.1620910114
   Dai XY, 2020, CANCER MED-US, V9, P5655, DOI 10.1002/cam4.3214
   Dalbeth N, 2016, LANCET, V388, P2039, DOI 10.1016/S0140-6736(16)00346-9
   de Oliveira EP, 2012, DIABETOL METAB SYNDR, V4, DOI 10.1186/1758-5996-4-12
   Del-Corso A, 2018, METABOLOMICS, V14, DOI 10.1007/s11306-017-1300-1
   Della Corte E, 1968, FEBS Lett, V2, P83, DOI 10.1016/0014-5793(68)80107-3
   DELLACOR.E, 1972, BIOCHEM J, V126, P739, DOI 10.1042/bj1260739
   DELLACORTE E, 1969, BIOCHIM BIOPHYS ACTA, V191, P164, DOI 10.1016/0005-2744(69)90327-1
   Deng T, 2016, ANNU REV PATHOL-MECH, V11, P421, DOI 10.1146/annurev-pathol-012615-044359
   Deretic V, 2016, J LEUKOCYTE BIOL, V100, P969, DOI 10.1189/jlb.4MR0216-079R
   DESROSIERS C, 1982, CAN J BIOCHEM CELL B, V60, P1109
   Diggle CP, 2009, J HISTOCHEM CYTOCHEM, V57, P763, DOI 10.1369/jhc.2009.953190
   Eibl G, 2021, CANCERS, V13, DOI 10.3390/cancers13205067
   ELION GB, 1966, BIOCHEM PHARMACOL, V15, P863, DOI 10.1016/0006-2952(66)90163-8
   Fini MA, 2021, CANCER METAB, V9, DOI 10.1186/s40170-021-00268-3
   Fini MA, 2012, CLIN TRANSL MED, V1, DOI 10.1186/2001-1326-1-16
   Frühbeck G, 2021, J INFLAMM RES, V14, P6431, DOI 10.2147/JIR.S335882
   García-Arroyo FE, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9100601
   Giebultowicz J, 2011, J ORAL PATHOL MED, V40, P726, DOI 10.1111/j.1600-0714.2011.01045.x
   Gluba-Brzózka A, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23063404
   Goncalves MD, 2019, SCIENCE, V363, P1345, DOI 10.1126/science.aat8515
   Gwinn DM, 2008, MOL CELL, V30, P214, DOI 10.1016/j.molcel.2008.03.003
   Hamady ZZR, 2013, BRIT J SURG, V100, P820, DOI 10.1002/bjs.9057
   HAUSLADEN A, 1994, J BIOL CHEM, V269, P29405
   Hayward BE, 1998, EUR J BIOCHEM, V257, P85, DOI 10.1046/j.1432-1327.1998.2570085.x
   Hediger MA, 2005, PHYSIOLOGY, V20, P125, DOI 10.1152/physiol.00039.2004
   Herman MA, 2021, CELL METAB, V33, P2329, DOI 10.1016/j.cmet.2021.09.010
   HILLE R, 1995, FASEB J, V9, P995, DOI 10.1096/fasebj.9.11.7649415
   Hsueh CY, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/1821969
   Hu LH, 2020, J CLIN ENDOCR METAB, V105, pE597, DOI 10.1210/clinem/dgz068
   Huang CF, 2020, WORLD J GASTROENTERO, V26, DOI 10.3748/wjg.v26.i44.7061
   Imaram W, 2010, FREE RADICAL BIO MED, V49, P275, DOI 10.1016/j.freeradbiomed.2010.04.010
   ITAKURA M, 1981, J CLIN INVEST, V67, P994, DOI 10.1172/JCI110150
   Jiang MX, 2021, FRONT GENET, V12, DOI 10.3389/fgene.2021.608311
   Johnson RJ, 2011, SEMIN NEPHROL, V31, P394, DOI 10.1016/j.semnephrol.2011.08.002
   Johnson RJ, 2010, EVOL ANTHROPOL, V19, P250, DOI 10.1002/evan.20266
   Khanna A, 2021, AM J CANCER RES, V11, P2343
   Kimura Y, 2020, ARTERIOSCL THROM VAS, V40, P570, DOI 10.1161/ATVBAHA.119.313224
   Koo HY, 2009, BIOCHEM BIOPH RES CO, V390, P285, DOI 10.1016/j.bbrc.2009.09.109
   KORIEH A, 1991, ARCH INT PHYSIOL BIO, V99, P455
   Kuhns VLH, 2021, BEST PRACT RES CL RH, V35, DOI 10.1016/j.berh.2021.101717
   Lanaspa MA, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms3434
   Lanaspa MA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0048801
   Lanaspa MA, 2012, J BIOL CHEM, V287, P40732, DOI 10.1074/jbc.M112.399899
   Lanaspa MA, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0047948, 10.1371/journal.pone.0048801]
   Lee HJ, 2018, BMB REP, V51, P429, DOI 10.5483/BMBRep.2018.51.9.197
   Li Z, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0147737
   Lima WG, 2015, BIOCHIMIE, V116, P17, DOI 10.1016/j.biochi.2015.06.025
   Liu HB, 2010, CANCER RES, V70, P6368, DOI 10.1158/0008-5472.CAN-09-4615
   Liu JH, 2020, J IMMUNOL RES, V2020, DOI 10.1155/2020/6765474
   Liu T, 2017, SIGNAL TRANSDUCT TAR, V2, DOI 10.1038/sigtrans.2017.23
   Lu J, 2019, NAT REV RHEUMATOL, V15, P413, DOI 10.1038/s41584-019-0222-x
   Lv Y, 2020, FRONT ONCOL, V10, DOI 10.3389/fonc.2020.00251
   Ma L, 2006, J BIOL CHEM, V281, P28721, DOI 10.1074/jbc.M601576200
   Madeddu C, 2022, CANCERS, V14, DOI 10.3390/cancers14020268
   Maiuolo J, 2016, INT J CARDIOL, V213, P8, DOI 10.1016/j.ijcard.2015.08.109
   Mandal AK, 2015, ANNU REV PHYSIOL, V77, P323, DOI 10.1146/annurev-physiol-021113-170343
   Martinon F, 2006, NATURE, V440, P237, DOI 10.1038/nature04516
   Martinon Fabio, 2010, Curr Rheumatol Rep, V12, P135, DOI 10.1007/s11926-010-0092-3
   Matozaki T, 2021, CANCER SCI, V112, P16, DOI 10.1111/cas.14702
   Mi SY, 2020, J CANCER, V11, P5236, DOI 10.7150/jca.46200
   Mubtasim N, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23052480
   Murono K, 2013, INT J COLORECTAL DIS, V28, P1065, DOI 10.1007/s00384-013-1656-2
   Nakagawa T, 2020, CANCER METAB, V8, DOI 10.1186/s40170-020-00222-9
   NAKAJIMA Y, 1969, HISTOCHEMISTRY, V18, P293
   Nassir Fatiha, 2015, Gastroenterol Hepatol (N Y), V11, P167
   Nishino T, 2008, FEBS J, V275, P3278, DOI 10.1111/j.1742-4658.2008.06489.x
   Niskanen LK, 2004, ARCH INTERN MED, V164, P1546, DOI 10.1001/archinte.164.14.1546
   Oda M, 2002, MOL BIOL EVOL, V19, P640, DOI 10.1093/oxfordjournals.molbev.a004123
   Oh AR, 2018, METABOLISM, V85, P286, DOI 10.1016/j.metabol.2018.04.006
   OH JH, 1967, CAN J PHYSIOL PHARM, V45, P121, DOI 10.1139/y67-013
   Oh YJ, 2022, KOREAN J INTERN MED, V37, P460, DOI 10.3904/kjim.2020.259
   Ouyang X, 2008, J HEPATOL, V48, P993, DOI 10.1016/j.jhep.2008.02.011
   Park TJ, 2017, SCIENCE, V356, P305, DOI 10.1126/science.aab3896
   PHILLIPS MI, 1985, BIOCHEM J, V228, P667, DOI 10.1042/bj2280667
   Preitner F, 2013, AM J PHYSIOL-RENAL, V305, pF786, DOI 10.1152/ajprenal.00083.2013
   PROCTOR P, 1970, NATURE, V228, P868, DOI 10.1038/228868a0
   Raïs B, 1999, FEBS LETT, V456, P113, DOI 10.1016/S0014-5793(99)00924-2
   RAIVIO KO, 1975, METABOLISM, V24, P861, DOI 10.1016/0026-0495(75)90133-X
   Ru LB, 2005, ARTHRITIS RHEUM-US, V52, P2936, DOI 10.1002/art.21238
   Russell FM, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22010186
   Saksela M, 1998, BIOL NEONATE, V74, P274, DOI 10.1159/000014034
   Sanchez-Garrido J, 2021, AUTOPHAGY, V17, P1571, DOI 10.1080/15548627.2020.1783119
   Sánchez-Lozada LG, 2008, AM J PHYSIOL-RENAL, V295, pF1134, DOI 10.1152/ajprenal.00104.2008
   Sanchez-Lozada LG, 2019, J BIOL CHEM, V294, P4272, DOI 10.1074/jbc.RA118.006158
   Santoni M, 2019, CANCERS, V11, DOI 10.3390/cancers11091225
   Saraswat M, 2006, MED SCI MONITOR, V12, pCR525
   Sarkadi B, 2020, FEBS LETT, V594, P4012, DOI 10.1002/1873-3468.13947
   Sautin YY, 2007, AM J PHYSIOL-CELL PH, V293, pC584, DOI 10.1152/ajpcell.00600.2006
   Schwab A, 2018, CANCER RES, V78, P1604, DOI 10.1158/0008-5472.CAN-17-2834
   Shi Y, 2003, NATURE, V425, P516, DOI 10.1038/nature01991
   Skenderian S, 2020, BIOLOGY-BASEL, V9, DOI 10.3390/biology9110405
   Strathearn LS, 2020, NUTRIENTS, V12, DOI 10.3390/nu12040933
   Suh S, 2019, DIABETES METAB J, V43, P733, DOI 10.4093/dmj.2019.0177
   Sun BC, 2012, J HEPATOL, V56, P704, DOI 10.1016/j.jhep.2011.09.020
   Takahashi MM, 2011, DIABETOL METAB SYNDR, V3, DOI 10.1186/1758-5996-3-7
   Taskoparan B, 2017, CELL ONCOL, V40, P563, DOI 10.1007/s13402-017-0351-7
   Terkeltaub R, 2010, NAT REV RHEUMATOL, V6, P30, DOI 10.1038/nrrheum.2009.236
   Testa A, 2014, CLIN J AM SOC NEPHRO, V9, P1059, DOI 10.2215/CJN.11041013
   Thakur S, 2021, ARCH PHARM RES, V44, P655, DOI 10.1007/s12272-021-01343-5
   Tsushima Y, 2013, J BIOL CHEM, V288, P27138, DOI 10.1074/jbc.M113.485094
   VANDENBERGHE G, 1977, BIOCHEM J, V162, P601, DOI 10.1042/bj1620601
   VANSCHAFTINGEN E, 1994, FASEB J, V8, P414, DOI 10.1096/fasebj.8.6.8168691
   Viollet B, 2009, ACTA PHYSIOL, V196, P81, DOI 10.1111/j.1748-1716.2009.01970.x
   Wang JW, 2020, ANN TRANSL MED, V8, DOI 10.21037/atm-20-3105
   Wang M, 2020, HEPATOLOGY, V72, P1617, DOI 10.1002/hep.31197
   Wang WJ, 2015, MEDIAT INFLAMM, V2015, DOI 10.1155/2015/680853
   Wang YF, 2021, INT IMMUNOPHARMACOL, V100, DOI 10.1016/j.intimp.2021.108107
   Wang Z, 2019, J NEPHROL, V32, P177, DOI 10.1007/s40620-018-0546-7
   Wilson RL, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051664
   Wiza C, 2012, AM J PHYSIOL-ENDOC M, V302, pE1453, DOI 10.1152/ajpendo.00660.2011
   Woo SK, 2002, PFLUG ARCH EUR J PHY, V444, P579, DOI 10.1007/s00424-002-0849-2
   WU XW, 1992, J MOL EVOL, V34, P78, DOI 10.1007/BF00163854
   Xu XX, 2016, PHARM BIOL, V54, P3151, DOI 10.1080/13880209.2016.1195847
   Yan SS, 2015, MEDIAT INFLAMM, V2015, DOI 10.1155/2015/764250
   Yiu A, 2017, ONCOTARGET, V8, P42332, DOI 10.18632/oncotarget.16198
   Zhang TJ, 2022, NUTRITION, V93, DOI 10.1016/j.nut.2021.111501
   Zhu YZ, 2014, BIOCHEM BIOPH RES CO, V447, P707, DOI 10.1016/j.bbrc.2014.04.080
NR 140
TC 40
Z9 41
U1 4
U2 24
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD OCT
PY 2022
VL 14
IS 19
AR 4959
DI 10.3390/cancers14194959
PG 22
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 5G2DX
UT WOS:000866815800001
PM 36230882
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Alvarez-Mercado, AI
   Rojano-Alfonso, C
   Micó-Carnero, M
   Caballeria-Casals, A
   Peralta, C
   Casillas-Ramírez, A
AF Alvarez-Mercado, Ana Isabel
   Rojano-Alfonso, Carlos
   Mico-Carnero, Marc
   Caballeria-Casals, Albert
   Peralta, Carmen
   Casillas-Ramirez, Arani
TI New Insights Into the Role of Autophagy in Liver Surgery in the Setting
   of Metabolic Syndrome and Related Diseases
SO FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
LA English
DT Review
DE autophagy; metabolic syndrome; ischemia-reperfusion; liver surgery;
   transplantation
ID ISCHEMIA-REPERFUSION INJURY; ENDOPLASMIC-RETICULUM STRESS; HEPATIC
   ISCHEMIA/REPERFUSION INJURY; ACTIVATED PROTEIN-KINASE; RAT STEATOTIC
   LIVER; FATTY LIVER; INSULIN-RESISTANCE; ANGIOTENSIN-II; MOUSE-LIVER;
   SIRTUIN 1
AB Visceral obesity is an important component of metabolic syndrome, a cluster of diseases that also includes diabetes and insulin resistance. A combination of these metabolic disorders damages liver function, which manifests as non-alcoholic fatty liver disease (NAFLD). NAFLD is a common cause of abnormal liver function, and numerous studies have established the enormously deleterious role of hepatic steatosis in ischemia-reperfusion (I/R) injury that inevitably occurs in both liver resection and transplantation. Thus, steatotic livers exhibit a higher frequency of post-surgical complications after hepatectomy, and using liver grafts from donors with NAFLD is associated with an increased risk of post-surgical morbidity and mortality in the recipient. Diabetes, another MetS-related metabolic disorder, also worsens hepatic I/R injury, and similar to NAFLD, diabetes is associated with a poor prognosis after liver surgery. Due to the large increase in the prevalence of MetS, NAFLD, and diabetes, their association is frequent in the population and therefore, in patients requiring liver resection and in potential liver graft donors. This scenario requires advancement in therapies to improve postoperative results in patients suffering from metabolic diseases and undergoing liver surgery; and in this sense, the bases for designing therapeutic strategies are in-depth knowledge about the molecular signaling pathways underlying the effects of MetS-related diseases and I/R injury on liver tissue. A common denominator in all these diseases is autophagy. In fact, in the context of obesity, autophagy is profoundly diminished in hepatocytes and alters mitochondrial functions in the liver. In insulin resistance conditions, there is a suppression of autophagy in the liver, which is associated with the accumulation of lipids, being this is a risk factor for NAFLD. Also, oxidative stress occurring in hepatic I/R injury promotes autophagy. The present review aims to shed some light on the role of autophagy in livers undergoing surgery and also suffering from metabolic diseases, which may lead to the discovery of effective therapeutic targets that could be translated from laboratory to clinical practice, to improve postoperative results of liver surgeries when performed in the presence of one or more metabolic diseases.
C1 [Alvarez-Mercado, Ana Isabel] Sch Pharm, Dept Biochem & Mol Biol 2, Granada, Spain.
   [Alvarez-Mercado, Ana Isabel] Parque Tecnol Ciencias Salud, Inst Nutr & Food Technol Jose Mataix, Biomed Res Ctr, Granada, Spain.
   [Alvarez-Mercado, Ana Isabel] Complejo Hosp Univ Granada, Inst Invest Biosanitaria Ibs GRANADA, Granada, Spain.
   [Rojano-Alfonso, Carlos; Mico-Carnero, Marc; Caballeria-Casals, Albert; Peralta, Carmen] Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.
   [Casillas-Ramirez, Arani] Hosp Reg Alta Especialidad Ciudad Victoria Bicent, Ciudad Victoria, Tamaulipas, Mexico.
   [Casillas-Ramirez, Arani] Univ Autonoma Tamaulipas, Fac Med & Ingn Sistemas Comp Matamoros, Matamoros, Mexico.
C3 Instituto de Investigacion Biosanitaria IBS Granada; University of
   Granada; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS;
   Universidad Autonoma de Tamaulipas
RP Peralta, C (corresponding author), Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.; Casillas-Ramírez, A (corresponding author), Hosp Reg Alta Especialidad Ciudad Victoria Bicent, Ciudad Victoria, Tamaulipas, Mexico.; Casillas-Ramírez, A (corresponding author), Univ Autonoma Tamaulipas, Fac Med & Ingn Sistemas Comp Matamoros, Matamoros, Mexico.
EM cperalta@clinic.cat; aranyc@yahoo.com
RI Alvarez, Ana/GXW-0690-2022; CASILLAS-RAMIREZ, ARANI/LFS-7121-2024;
   Peralta, Carmen/M-8170-2014; Alvarez-Mercado, Ana I./C-3466-2019
OI Rojano Alfonso, Carlos/0000-0001-5035-9626; Peralta,
   Carmen/0000-0002-5767-0676; CASILLAS-RAMIREZ, ARANI/0000-0001-7533-1478;
   Caballeria Casals, Albert/0000-0003-2954-4477; Alvarez-Mercado, Ana
   I./0000-0002-8476-9970
FU Ministerio de Ciencia, Innovacion y Universidades Madrid, Spain
   [RTI2018-095114-B-I00]; European Union (Fondos FEDER, "una manera de
   hacer Europa"); CERCA Program/Generalitat de Catalunya; Secretaria d'
   Universitats I Recerca del Departament d' Economia I Coneixement
   Barcelona, Spain [2017_SGR_551]; COST action [CA17103, CA17112, CA17121,
   CA17126]; Consejo Nacional de Ciencia y Tecnologia (CONACYT), Fondo
   Sectorial de Investigacion para la Educacion, Mexico [257743]; FCT
   (Fundacio Catalana de trasplantament), Spain; Academy of Finland (AKA)
   [257743] Funding Source: Academy of Finland (AKA)
FX This research was funded by the Ministerio de Ciencia, Innovacion y
   Universidades (Project Grant RTI2018-095114-B-I00) Madrid, Spain;
   European Union (Fondos FEDER, "una manera de hacer Europa"); CERCA
   Program/Generalitat de Catalunya; the Secretaria d' Universitats I
   Recerca del Departament d' Economia I Coneixement (Project Grant
   2017_SGR_551) Barcelona, Spain, by the COST action Programs CA17103
   (DARTER), CA17112 (PRO-EURO-DILI-NET), CA17121 (COMULIS), and CA17126
   (TUMIEE), and by the Consejo Nacional de Ciencia y Tecnologia (CONACYT),
   Fondo Sectorial de Investigacion para la Educacion (Project grant
   257743), Mexico. MM-C is the recipient of a fellowship from FCT
   (Fundacio Catalana de trasplantament), Spain.
CR Adeva-Andany MM, 2019, MITOCHONDRION, V46, P73, DOI 10.1016/j.mito.2018.02.009
   Adkins Y, 2013, LAB INVEST, V93, P1313, DOI 10.1038/labinvest.2013.123
   Alfany-Fernandez I, 2009, AM J TRANSPLANT, V9, P439, DOI 10.1111/j.1600-6143.2008.02521.x
   Alipourfard I, 2019, MEDIAT INFLAMM, V2019, DOI 10.1155/2019/3560819
   Alvarez-Mercado AI, 2019, TRANSPLANTATION, V103, P1349, DOI 10.1097/TP.0000000000002636
   Archuleta TL, 2009, FREE RADICAL BIO MED, V47, P1486, DOI 10.1016/j.freeradbiomed.2009.08.014
   Bai G, 2018, J VET RES, V62, P395, DOI 10.2478/jvetres-2018-0056
   Baldini F, 2020, BBA-MOL CELL BIOL L, V1865, DOI 10.1016/j.bbalip.2019.158586
   Bechmann LP, 2012, J HEPATOL, V56, P952, DOI 10.1016/j.jhep.2011.08.025
   Behrends M, 2010, J GASTROINTEST SURG, V14, P528, DOI 10.1007/s11605-009-1112-3
   Mosbah I, 2010, CELL DEATH DIS, V1, DOI 10.1038/cddis.2010.29
   Bi JB, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/6946037
   Biel TG, 2016, CELL DEATH DIFFER, V23, P279, DOI 10.1038/cdd.2015.96
   Caraceni P, 2005, J SURG RES, V124, P160, DOI 10.1016/j.jss.2004.10.007
   Carotti S, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.00850
   Carrasco-Chaumel E, 2005, J HEPATOL, V43, P997, DOI 10.1016/j.jhep.2005.05.021
   Casillas-Ramirez A, 2008, CRIT CARE MED, V36, P1256, DOI 10.1097/CCM.0b013e31816a023c
   Casillas-Ramírez A, 2011, J PHARMACOL EXP THER, V338, P143, DOI 10.1124/jpet.110.177691
   Chae SM, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0243873
   Chang AL, 2016, SURGERY, V160, P1111, DOI 10.1016/j.surg.2016.06.015
   Chen K, 2017, ACTA PHARMACOL SIN, V38, P672, DOI 10.1038/aps.2016.108
   Chen KQ, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.116.004078
   Chen XL, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.01356
   Chen XT, 2019, J CELL MOL MED, V23, P4290, DOI 10.1111/jcmm.14320
   Cho HI, 2017, BIOCHEM PHARMACOL, V131, P40, DOI 10.1016/j.bcp.2017.02.008
   Choi JW, 2018, METABOLISM, V78, P43, DOI 10.1016/j.metabol.2017.09.005
   Chorny A, 2008, J IMMUNOL, V180, P8369, DOI 10.4049/jimmunol.180.12.8369
   Cui F, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.00013
   Cui ZL, 2018, CELL PHYSIOL BIOCHEM, V48, P328, DOI 10.1159/000491732
   Degli Esposti D, 2011, Cell Death Dis, V2, pe111, DOI 10.1038/cddis.2010.89
   Deng JF, 2018, DRUG DES DEV THER, V12, P4067, DOI 10.2147/DDDT.S182292
   du Toit A, 2018, AUTOPHAGY, V14, P1060, DOI 10.1080/15548627.2018.1469590
   Durczynski A, 2013, SURG TODAY, V43, P534, DOI 10.1007/s00595-012-0268-8
   Dusabimana T, 2019, EXP MOL MED, V51, DOI 10.1038/s12276-019-0245-z
   El Atrache MM, 2012, CLIN TRANSPLANT, V26, pE505, DOI 10.1111/ctr.12014
   Elias-Miró M, 2012, LIVER TRANSPLANT, V18, P1198, DOI 10.1002/lt.23489
   Engeli S, 2003, INT J BIOCHEM CELL B, V35, P807, DOI 10.1016/S1357-2725(02)00311-4
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   Cornide-Petronio ME, 2017, J CELL MOL MED, V21, P2344, DOI 10.1111/jcmm.13156
   Feng J, 2017, DRUG DES DEV THER, V11, P1989, DOI 10.2147/DDDT.S136792
   Fernández L, 2004, AM J TRANSPLANT, V4, P888, DOI 10.1111/j.1600-6143.2004.00447.x
   Forbes SJ, 2016, NAT REV GASTRO HEPAT, V13, P473, DOI 10.1038/nrgastro.2016.97
   Fortunato F, 2009, GASTROENTEROLOGY, V137, P350, DOI 10.1053/j.gastro.2009.04.003
   Gadiparthi C, 2020, J CLIN TRANSL HEPATO, V8, P215, DOI 10.14218/JCTH.2020.00014
   Gjorgjieva M, 2019, CELL STRESS, V3, P86, DOI 10.15698/cst2019.03.179
   Gong LL, 2018, J PHARMACOL SCI, V136, P189, DOI 10.1016/j.jphs.2017.11.007
   Gong LL, 2016, J PHARMACOL EXP THER, V359, P392, DOI 10.1124/jpet.116.236562
   Gonzalez CD, 2011, AUTOPHAGY, V7, P2, DOI 10.4161/auto.7.1.13044
   Gonzalez HD, 2010, WORLD J GASTRO SURG, V2, P389, DOI 10.4240/wjgs.v2.i12.389
   González-Rodríguez A, 2014, CELL DEATH DIS, V5, DOI 10.1038/cddis.2014.162
   Goto T, 2017, FEBS LETT, V591, P624, DOI 10.1002/1873-3468.12570
   Gotoh K, 2009, AUTOPHAGY, V5, P351, DOI 10.4161/auto.5.3.7650
   Gracia-Sancho J, 2013, J HEPATOL, V58, P1140, DOI 10.1016/j.jhep.2013.02.005
   Gupta NA, 2014, AM J PHYSIOL-GASTR L, V307, pG1088, DOI 10.1152/ajpgi.00210.2014
   Han SB, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0109120
   He Q, 2016, J MOL ENDOCRINOL, V57, P251, DOI 10.1530/JME-16-0139
   Homma T, 2020, FREE RADICAL RES, V54, P931, DOI 10.1080/10715762.2020.1734588
   Houben T, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-03796-5
   Hsu HC, 2016, EUR J NUTR, V55, P2031, DOI 10.1007/s00394-015-1017-8
   Huang Q, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18051063
   Inami Y, 2011, BIOCHEM BIOPH RES CO, V412, P618, DOI 10.1016/j.bbrc.2011.08.012
   Ingaramo PI, 2011, MOL IMMUNOL, V48, P1397, DOI 10.1016/j.molimm.2011.03.015
   Ji J, 2020, INT IMMUNOPHARMACOL, V84, DOI 10.1016/j.intimp.2020.106529
   Jiang T, 2019, INT IMMUNOPHARMACOL, V74, DOI 10.1016/j.intimp.2019.105711
   Jiménez-Castro MB, 2012, AM J TRANSPLANT, V12, P3257, DOI 10.1111/j.1600-6143.2012.04261.x
   Jiménez-Castro MB, 2017, CLIN SCI, V131, P733, DOI 10.1042/CS20160676
   Jiménez-Castro MB, 2013, J HEPATOL, V59, P1208, DOI 10.1016/j.jhep.2013.07.015
   Jin Y, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19113445
   Jung SH, 2020, REDOX BIOL, V37, DOI 10.1016/j.redox.2020.101751
   Kabeya Y, 2000, EMBO J, V19, P5720, DOI 10.1093/emboj/19.21.5720
   Kan CY, 2017, J SURG RES, V216, P207, DOI 10.1016/j.jss.2017.04.012
   Kang RA, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-34655-6
   Khader A, 2016, CRIT CARE MED, V44, pE651, DOI 10.1097/CCM.0000000000001637
   Kim BW, 2016, BMB REP, V49, P73, DOI 10.5483/BMBRep.2016.49.2.265
   Kim HJ, 2017, FREE RADICAL BIO MED, V110, P81, DOI 10.1016/j.freeradbiomed.2017.05.026
   Kim KH, 2013, NAT MED, V19, P83, DOI 10.1038/nm.3014
   Kirisako T, 2000, J CELL BIOL, V151, P263, DOI 10.1083/jcb.151.2.263
   Klionsky DJ, 2021, AUTOPHAGY, V17, P1, DOI 10.1080/15548627.2020.1797280
   Koga H, 2010, FASEB J, V24, P3052, DOI 10.1096/fj.09-144519
   Kong DF, 2019, HEPATOL RES, V49, P462, DOI 10.1111/hepr.13287
   Kou XN, 2020, IRAN J BASIC MED SCI, V23, P1232, DOI 10.22038/ijbms.2020.44101.10334
   Kramer CK, 2013, LANCET DIABETES ENDO, V1, P28, DOI 10.1016/S2213-8587(13)70006-8
   Kuo NC, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9100924
   Kurahashi T, 2015, BIOCHEM BIOPH RES CO, V467, P866, DOI 10.1016/j.bbrc.2015.10.052
   Lamark T, 2003, J BIOL CHEM, V278, P34568, DOI 10.1074/jbc.M303221200
   Lee DH, 2020, BIOMED PHARMACOTHER, V125, DOI 10.1016/j.biopha.2020.109950
   Lee HS, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036221
   Lee K, 2018, MOL CELL PROTEOMICS, V17, P2371, DOI 10.1074/mcp.RA118.000961
   Lee SC, 2016, AM J TRANSPLANT, V16, P2042, DOI 10.1111/ajt.13729
   Lee S, 2017, ONCOTARGET, V8, P63370, DOI 10.18632/oncotarget.18812
   Lee S, 2015, PEDIATR DIABETES, V16, P211, DOI 10.1111/pedi.12141
   Lehmann TG, 2003, TRANSPLANTATION, V76, P28, DOI 10.1097/01.TP.0000065299.29900.17
   Li HT, 2020, PEERJ, V8, DOI 10.7717/peerj.8665
   Li JJ, 2017, BIOMED PHARMACOTHER, V94, P687, DOI 10.1016/j.biopha.2017.07.109
   Li JJ, 2020, EXP THER MED, V19, P2588, DOI 10.3892/etm.2020.8497
   Li M, 2018, J IMMUNOL RES, V2018, DOI 10.1155/2018/9807139
   Li RB, 2018, REDOX BIOL, V18, P229, DOI 10.1016/j.redox.2018.07.011
   Li SW, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0187810
   Li SP, 2016, LIVER TRANSPLANT, V22, P1697, DOI 10.1002/lt.24606
   Li XZ, 2017, MOLECULES, V22, DOI 10.3390/molecules22050699
   Lin YC, 2016, J HEPATOL, V65, P1209, DOI 10.1016/j.jhep.2016.06.029
   Lin YB, 2017, BIOCHEM BIOPH RES CO, V483, P885, DOI 10.1016/j.bbrc.2017.01.028
   Linecker M, 2017, ANN SURG, V266, P324, DOI 10.1097/SLA.0000000000001968
   Ling Q, 2017, CELL PHYSIOL BIOCHEM, V41, P2461, DOI 10.1159/000475915
   Liu AD, 2016, ONCOTARGET, V7, P78372, DOI 10.18632/oncotarget.13281
   Liu H, 2019, BIOCHEM BIOPH RES CO, V519, P227, DOI 10.1016/j.bbrc.2019.08.162
   Liu HY, 2009, J BIOL CHEM, V284, P31484, DOI 10.1074/jbc.M109.033936
   Liu PY, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201800164
   Liu TT, 2019, INT J CLIN EXP PATHO, V12, P640
   Liu ZZ, 2020, MOL MED REP, V22, P2373, DOI 10.3892/mmr.2020.11312
   Lopez-Neblina F, 2005, J INVEST SURG, V18, P335, DOI 10.1080/08941930500328862
   Manna P, 2010, FREE RADICAL BIO MED, V48, P1465, DOI 10.1016/j.freeradbiomed.2010.02.025
   Mao YQ, 2015, INT J MOL SCI, V16, P21911, DOI 10.3390/ijms160921911
   Mareninova OA, 2009, J CLIN INVEST, V119, P3340, DOI 10.1172/JCI38674
   Massip-Salcedo M, 2006, AM J PATHOL, V168, P1474, DOI 10.2353/ajpath.2006.050645
   Massip-Salcedo M, 2008, HEPATOLOGY, V47, P461, DOI 10.1002/hep.21935
   Matter MS, 2014, J HEPATOL, V60, P855, DOI 10.1016/j.jhep.2013.11.031
   McCormack L, 2007, ANN SURG, V245, P923, DOI 10.1097/01.sla.0000251747.80025.b7
   Mei S, 2011, J PHARMACOL EXP THER, V339, P487, DOI 10.1124/jpet.111.184341
   Menikdiwela KR, 2020, CELL DEATH DIS, V11, DOI 10.1038/s41419-020-2275-9
   Micó-Carnero M, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22010044
   Minor T, 2011, AM J TRANSPLANT, V11, P2627, DOI 10.1111/j.1600-6143.2011.03731.x
   Miyagawa K, 2016, AM J PATHOL, V186, P1861, DOI 10.1016/j.ajpath.2016.03.003
   Miyamoto S, 2016, CIRCULATION, V133, P1225, DOI 10.1161/CIRCULATIONAHA.116.021796
   Miyauchi T, 2019, P NATL ACAD SCI USA, V116, P13533, DOI 10.1073/pnas.1820282116
   Mizushima N, 2010, CELL, V140, P313, DOI 10.1016/j.cell.2010.01.028
   Nakamura K, 2019, J CLIN INVEST, V129, P3420, DOI 10.1172/JCI127550
   Nakamura K, 2018, AM J TRANSPLANT, V18, P1110, DOI 10.1111/ajt.14586
   Nakao YM, 2012, P JPN ACAD B-PHYS, V88, P454, DOI 10.2183/pjab.88.454
   Ning XJ, 2018, MOL MED REP, V18, P5663, DOI 10.3892/mmr.2018.9606
   Oberkofler H, 2010, DIABETOLOGIA, V53, P1971, DOI 10.1007/s00125-010-1772-2
   Ogihara T, 2002, HYPERTENSION, V40, P872, DOI 10.1161/01.HYP.0000040262.48405.A8
   Panisello-Roselló A, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19020348
   Panisello-Roselló A, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18112287
   Pankiv S, 2007, J BIOL CHEM, V282, P24131, DOI 10.1074/jbc.M702824200
   Pantazi E, 2015, WORLD J GASTROENTERO, V21, P1765, DOI 10.3748/wjg.v21.i6.1765
   Parafati M, 2015, J NUTR BIOCHEM, V26, P938, DOI 10.1016/j.jnutbio.2015.03.008
   Pereira S, 2015, J ENDOCRINOL, V225, P1, DOI 10.1530/JOE-14-0676
   Putnam K, 2012, AM J PHYSIOL-HEART C, V302, pH1219, DOI 10.1152/ajpheart.00796.2011
   Quan W, 2012, DIABETOLOGIA, V55, P392, DOI 10.1007/s00125-011-2350-y
   Ricca L, 2015, TRANSPLANTATION, V99, P1633, DOI 10.1097/TP.0000000000000685
   Ricchi M, 2009, J GASTROEN HEPATOL, V24, P830, DOI 10.1111/j.1440-1746.2008.05733.x
   Ruan ZY, 2020, CELL BIOL INT, V44, P306, DOI 10.1002/cbin.11234
   Samala N, 2017, J DIABETES COMPLICAT, V31, P1630, DOI 10.1016/j.jdiacomp.2017.07.014
   Sato S, 2018, METHODS MOL BIOL, V1759, P9, DOI 10.1007/7651_2017_7
   Schleinitz D, 2014, DIABETOLOGIA, V57, P1276, DOI 10.1007/s00125-014-3214-z
   Schott MB, 2019, J CELL BIOL, V218, P3320, DOI 10.1083/jcb.201803153
   Schulze RJ, 2014, AUTOPHAGY, V10, P388, DOI 10.4161/auto.27486
   Selzner M, 2000, HEPATOLOGY, V32, P1280, DOI 10.1053/jhep.2000.20528
   Settembre C, 2013, NAT CELL BIOL, V15, P647, DOI 10.1038/ncb2718
   Shaker ME, 2016, BIOCHEM PHARMACOL, V112, P90, DOI 10.1016/j.bcp.2016.05.003
   Shao N, 2018, GASTROENT RES PRACT, V2018, DOI 10.1155/2018/1864307
   Simmons RK, 2010, DIABETOLOGIA, V53, P600, DOI 10.1007/s00125-009-1620-4
   Singh R, 2009, NATURE, V458, P1131, DOI 10.1038/nature07976
   Singh RK, 2012, INT J OPT, V2012, DOI [10.1155/2012/282041, 10.1155/2012/832086]
   Sinha RA, 2014, HEPATOLOGY, V59, P1366, DOI 10.1002/hep.26667
   Stayrook KR, 2005, ENDOCRINOLOGY, V146, P984, DOI 10.1210/en.2004-0965
   Su ZQ, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.01193
   Sun XL, 2019, J CELL BIOCHEM, V120, P4255, DOI 10.1002/jcb.27711
   Tan RM, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-33028-3
   Tanaka S, 2016, HEPATOLOGY, V64, P1994, DOI 10.1002/hep.28820
   Tang B, 2019, GENE, V686, P56, DOI 10.1016/j.gene.2018.10.059
   Tashiro H, 2014, SURG TODAY, V44, P1611, DOI 10.1007/s00595-013-0736-9
   Toledo M, 2018, CELL METAB, V28, P268, DOI 10.1016/j.cmet.2018.05.023
   Uchiyama Y, 2001, ARCH HISTOL CYTOL, V64, P233, DOI 10.1679/aohc.64.233
   Vanhorebeek I, 2011, J CLIN ENDOCR METAB, V96, pE633, DOI 10.1210/jc.2010-2563
   Perez LV, 2016, TRANSPL P, V48, P2519, DOI 10.1016/j.transproceed.2016.08.029
   Wan XY, 2016, CAN J GASTROENTEROL, V2016, DOI 10.1155/2016/6489012
   Wang CS, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-02332-3
   Wang HT, 2012, CELL SIGNAL, V24, P17, DOI 10.1016/j.cellsig.2011.08.010
   Wang H, 2015, ENDOCRINOLOGY, V156, P169, DOI 10.1210/en.2014-1454
   Wang HJ, 2015, AUTOPHAGY, V11, P2089, DOI 10.1080/15548627.2015.1091139
   Wang JY, 2020, INT J MOL MED, V45, P1875, DOI 10.3892/ijmm.2020.4551
   Wang Q, 2020, IMMUNOL CELL BIOL, V98, P54, DOI 10.1111/imcb.12297
   Wang RR, 2017, INT J MOL MED, V40, P1537, DOI 10.3892/ijmm.2017.3121
   Wang WW, 2019, MEDIAT INFLAMM, V2019, DOI 10.1155/2019/3240713
   Wang XJ, 2018, FASEB J, V32, P37, DOI 10.1096/fj.201601393R
   Wang ZX, 2017, BIOCHEM BIOPH RES CO, V486, P116, DOI 10.1016/j.bbrc.2017.03.010
   Williamson RM, 2011, DIABETES CARE, V34, P1139, DOI 10.2337/dc10-2229
   Wu LW, 2017, GASTROENT RES PRACT, V2017, DOI 10.1155/2017/9724217
   Xiang SH, 2020, DRUG DES DEV THER, V14, P129, DOI 10.2147/DDDT.S229063
   Xiong J, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17030387
   Xu DW, 2017, CELL DEATH DIS, V8, DOI 10.1038/cddis.2017.386
   Xu SZ, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-15521-3
   Xu Y, 2020, FREE RADICAL BIO MED, V160, P871, DOI 10.1016/j.freeradbiomed.2020.09.015
   Xue ZZ, 2020, THERANOSTICS, V10, P4453, DOI 10.7150/thno.42354
   Yan B, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0239119
   Yan H, 2017, MOL MED REP, V15, P180, DOI 10.3892/mmr.2016.5966
   Yang JH, 2015, AM J TRANSL RES, V7, P2630
   Yang L, 2010, CELL METAB, V11, P467, DOI 10.1016/j.cmet.2010.04.005
   Yasuda-Yamahara M, 2015, BIOCHEM BIOPH RES CO, V465, P249, DOI 10.1016/j.bbrc.2015.08.010
   Yu Q, 2019, INT IMMUNOPHARMACOL, V70, P435, DOI 10.1016/j.intimp.2019.02.024
   Yu X, 2019, J FUNCT FOODS, V53, P166, DOI 10.1016/j.jff.2018.12.016
   Yu Y, 2017, SCI REP-UK, V7, DOI 10.1038/srep43684
   Zaouali MA, 2017, TRANSPL P, V49, P765, DOI 10.1016/j.transproceed.2017.01.071
   Zaouali MA, 2013, J PINEAL RES, V55, P65, DOI 10.1111/jpi.12051
   Zaouali MA, 2013, EXP MOL PATHOL, V94, P352, DOI 10.1016/j.yexmp.2012.12.005
   Zeng XP, 2019, ARTIF ORGANS, V43, pE320, DOI 10.1111/aor.13525
   Zhang N, 2019, EXP BIOL MED, V244, P1695, DOI 10.1177/1535370219878651
   Zhang X, 2016, J HEPATOL, V64, P160, DOI 10.1016/j.jhep.2015.09.005
   Zhang ZL, 2018, BIOMED PHARMACOTHER, V97, P339, DOI 10.1016/j.biopha.2017.07.168
   Zhao Q, 2016, CELL DEATH DIS, V7, DOI 10.1038/cddis.2016.66
   Zhou H, 2018, J PINEAL RES, V64, DOI 10.1111/jpi.12450
   Zhu JB, 2016, CELL PHYSIOL BIOCHEM, V39, P2364, DOI 10.1159/000452506
   Zhu SL, 2016, MOL CELL BIOCHEM, V420, P107, DOI 10.1007/s11010-016-2774-2
NR 205
TC 9
Z9 10
U1 0
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-634X
J9 FRONT CELL DEV BIOL
JI Front. Cell. Dev. Biol.
PD JUN 1
PY 2021
VL 9
AR 670273
DI 10.3389/fcell.2021.670273
PG 31
WC Cell Biology; Developmental Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Developmental Biology
GA SS0NL
UT WOS:000661439100001
PM 34141709
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Byrne, ML
   Horne, S
   O'Brien-Simpson, NM
   Walsh, KA
   Reynolds, EC
   Schwartz, OS
   Whittle, S
   Simmons, JG
   Sheeber, L
   Allen, NB
AF Byrne, Michelle L.
   Horne, Sally
   O'Brien-Simpson, Neil M.
   Walsh, Katrina A.
   Reynolds, Eric C.
   Schwartz, Orli S.
   Whittle, Sarah
   Simmons, Julian G.
   Sheeber, Lisa
   Allen, Nicholas B.
TI Associations Between Observed Parenting Behavior and Adolescent
   Inflammation Two and a Half Years Later in a Community Sample
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE adolescence; parenting emotional behavior; inflammation; salivary
   C-reactive protein; family environments
ID C-REACTIVE PROTEIN; EARLY-LIFE; SALIVARY BIOMARKERS; FAMILY
   INTERACTIONS; METABOLIC SYNDROME; IMMUNE FUNCTION; STRESS; DEPRESSION;
   RESPONSES; PREDICT
AB Objective: Family environments have an effect on physical health during adolescence, and a possible underlying mechanism is inflammation. However, little is known about the association between observed parenting behaviors and immune system functioning. The current study examined whether positive and negative emotional parental behaviors observed during family interactions were associated with inflammation in adolescents. Method: Sixty-one parent-adolescent dyads (37 male adolescents, 60.6%; 15 male parents, 24.6%) were observed during 2 laboratory-based interaction tasks designed to elicit positive and conflictual emotional behaviors, respectively. Frequency of aggressive and positive parental behavior was coded. Adolescents were followed up approximately 2.5 years later and salivary concentrations of the inflammatory biomarker C-reactive protein (sCRP) were measured. Results: Controlling for BMI and depressive symptoms, lower sCRP was associated both with greater frequency of positive parental behaviors, t = -3.087, p=.003 and less frequency of aggressive parental behavior (t = 2.087, p=.041) in the conflictual task. Trend associations between positive behavior during the positive task and lower sCRP were also found. Conclusions: This is the first study to show that observed positive parenting is associated with lower levels of inflammation in adolescents.
C1 [Byrne, Michelle L.; Allen, Nicholas B.] Univ Oregon, Dept Psychol, Eugene, OR 97403 USA.
   [Horne, Sally; Schwartz, Orli S.; Allen, Nicholas B.] Univ Melbourne, Melbourne Sch Psychol Sci, Parkville, Vic, Australia.
   [O'Brien-Simpson, Neil M.; Walsh, Katrina A.; Reynolds, Eric C.] Univ Melbourne, Melbourne Dent Sch, Victoria, Parkville, Vic, Australia.
   [Whittle, Sarah; Simmons, Julian G.] Univ Melbourne, Dept Psychiat, Melbourne Neuropsychiat Ctr, Melbourne Sch Psychol Sci, Parkville, Vic, Australia.
   [Whittle, Sarah; Simmons, Julian G.] Melbourne Hlth, Parkville, Vic, Australia.
   [Sheeber, Lisa] Oregon Res Inst, Eugene, OR 97403 USA.
   [Allen, Nicholas B.] Univ Melbourne, Ctr Youth Mental Hlth, Orygen Res Ctr, Parkville, Vic, Australia.
C3 University of Oregon; University of Melbourne; University of Melbourne;
   University of Melbourne; Oregon Research Institute; Orygen, The National
   Centre of Excellence in Youth Mental Health; University of Melbourne
RP Allen, NB (corresponding author), 1227 Univ Oregon, Dept Psychol, Eugene, OR 97403 USA.
EM nallen3@uoregon.edu
RI Schwartz, Orli/ABD-3996-2021; O'Brien-Simpson, Neil/B-2901-2009;
   Whittle, Sarah/I-2200-2014
OI O'Brien-Simpson, Neil/0000-0001-8462-5603; Walsh,
   Katrina/0000-0002-0927-2008; Simmons, Julian G./0000-0002-7228-1847;
   Byrne, Michelle/0000-0002-4180-8095; Schwartz, Orli/0000-0001-7634-3737;
   Whittle, Sarah/0000-0003-3145-1528
CR Allen NB, 2012, BIOL PSYCHOL, V90, P80, DOI 10.1016/j.biopsycho.2012.02.013
   [Anonymous], CHILD DEV PERSPECTIV
   [Anonymous], 2001, 2001 M SOC RES CHILD
   Appleton AA, 2012, HEALTH PSYCHOL, V31, P413, DOI 10.1037/a0027300
   Black S, 2004, J BIOL CHEM, V279, P48487, DOI 10.1074/jbc.R400025200
   Blandon AY, 2010, DEV PSYCHOL, V46, P1089, DOI 10.1037/a0020678
   Bouman A, 2005, HUM REPROD UPDATE, V11, P411, DOI 10.1093/humupd/dmi008
   Breslin WL, 2012, PEDIATRICS, V129, pE1180, DOI 10.1542/peds.2011-2477
   Bronfenbrenner U., 1989, Six Theories of Child Development: Revised Formulations and Current Issues, P187
   Byrne ML, 2017, J FAM PSYCHOL, V31, P374, DOI 10.1037/fam0000254
   Byrne ML, 2013, BRAIN BEHAV IMMUN, V34, P164, DOI 10.1016/j.bbi.2013.08.010
   Caserta MT, 2008, BRAIN BEHAV IMMUN, V22, P933, DOI 10.1016/j.bbi.2008.01.007
   Cassano M, 2006, J CLIN CHILD ADOLESC, V35, P583, DOI 10.1207/s15374424jccp3504_10
   Chabrol H, 2002, ENCEPHALE, V28, P429
   Cicchetti D, 2015, DEV PSYCHOPATHOL, V27, P553, DOI 10.1017/S0954579415000152
   Cohen S, 2004, AM PSYCHOL, V59, P676, DOI 10.1037/0003-066X.59.8.676
   Copeland WE, 2012, BIOL PSYCHIAT, V71, P15, DOI 10.1016/j.biopsych.2011.09.023
   Danese A, 2008, ARCH GEN PSYCHIAT, V65, P409, DOI 10.1001/archpsyc.65.4.409
   Davenport E, 2011, J ADOLESCENCE, V34, P829, DOI 10.1016/j.adolescence.2011.02.003
   Delany FM, 2016, PSYCHONEUROENDOCRINO, V63, P228, DOI 10.1016/j.psyneuen.2015.10.003
   Dillon MC, 2010, BIOMARK INSIGHTS, V5, P57
   Fagundes CP, 2011, SOC PERSONAL PSYCHOL, V5, P891, DOI 10.1111/j.1751-9004.2011.00392.x
   Fuligni AJ, 2009, PSYCHOSOM MED, V71, P329, DOI 10.1097/PSY.0b013e3181921b1f
   GANZEBOOM HBG, 1992, SOC SCI RES, V21, P1, DOI 10.1016/0049-089X(92)90017-B
   GILBOA E, 1994, EMOTIONS: ESSAYS ON EMOTION THEORY, P135
   Gillum RF, 2003, J NATL MED ASSOC, V95, P545
   Glowinska Barbara, 2003, Wiad Lek, V56, P109
   Goodson JM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0098799
   Gotlib I.H., 1992, Psychological aspects of depression: Toward a cognitive interpersonal integration
   Gottman JM, 1998, J MARRIAGE FAM, V60, P5, DOI 10.2307/353438
   Granger DA, 2007, PHYSIOL BEHAV, V92, P583, DOI 10.1016/j.physbeh.2007.05.004
   Gunnar M, 2007, ANNU REV PSYCHOL, V58, P145, DOI 10.1146/annurev.psych.58.110405.085605
   Hennessy MB, 2004, PHYSIOL BEHAV, V81, P5, DOI 10.1016/j.physbeh.2003.11.008
   Holt-Lunstad J, 2010, PLOS MED, V7, DOI 10.1371/journal.pmed.1000316
   HOPS H, 1995, J CLIN CHILD PSYCHOL, V24, P193, DOI 10.1207/s15374424jccp2402_7
   HOPS H, 1987, J CONSULT CLIN PSYCH, V55, P341, DOI 10.1037/0022-006X.55.3.341
   Howren MB, 2009, PSYCHOSOM MED, V71, P171, DOI 10.1097/PSY.0b013e3181907c1b
   Jones FL, 2001, WORK EMPLOY SOC, V15, P539, DOI 10.1177/09500170122119147
   Kaplan R C, 2001, Heart Dis, V3, P326
   Katz LF, 2007, SOC DEV, V16, P343, DOI 10.1111/j.1467-9507.2007.00388.x
   Kiecolt-Glaser JK, 2005, ARCH GEN PSYCHIAT, V62, P1377, DOI 10.1001/archpsyc.62.12.1377
   Lambert M, 2004, CLIN CHEM, V50, P1762, DOI 10.1373/clinchem.2004.036418
   Laurent HK, 2016, BIOL PSYCHOL, V118, P17, DOI 10.1016/j.biopsycho.2016.04.066
   Lee A, 2012, J PERIODONTOL, V83, P79, DOI 10.1902/jop.2011.110060
   LEWINSOHN PM, 1994, J ABNORM PSYCHOL, V103, P302, DOI 10.1037/0021-843X.103.2.302
   Little R. J. A., 1987, STAT ANAL MISSING DA
   Lucas T, 2016, HEALTH PSYCHOL, V35, P366, DOI 10.1037/hea0000284
   Luchetti M, 2014, PSYCHONEUROENDOCRINO, V50, P181, DOI 10.1016/j.psyneuen.2014.08.014
   Lutgendorf SK, 2000, INT J BEHAV MED, V7, P127, DOI 10.1207/S15327558IJBM0702_3
   MacPhillamy D.J., 1976, MANUAL PLEASANT EVEN
   Manson S.M., 1990, PSYCHOL ASSESSMENT J, V2, P231, DOI [10.1037/1040-3590.2.3.231, DOI 10.1037/1040-3590.2.3.231]
   Marks G.N., 2000, The measurement of socioeconomic status for the reporting of nationally comparable outcomes of schooling
   Meier-Ewert HK, 2001, CLIN CHEM, V47, P426
   Miller GE, 2006, CURR DIR PSYCHOL SCI, V15, P269, DOI 10.1111/j.1467-8721.2006.00450.x
   Miller GE, 2011, PSYCHOL SCI, V22, P1591, DOI 10.1177/0956797611419170
   Miller GE, 2010, PSYCHOL SCI, V21, P848, DOI 10.1177/0956797610370161
   Mohamed R, 2012, CLIN TRANSL MED, V1, DOI 10.1186/2001-1326-1-19
   MORRIS NM, 1980, J YOUTH ADOLESCENCE, V9, P271, DOI 10.1007/BF02088471
   Naidoo T, 2012, CARDIOVASC J AFR, V23, P501, DOI 10.5830/CVJA-2012-058
   O'Connor TG, 2015, BRAIN BEHAV IMMUN, V48, P265, DOI 10.1016/j.bbi.2015.04.002
   Oldehinkel AJ, 2011, DEV PSYCHOPATHOL, V23, P679, DOI 10.1017/S0954579411000095
   Ouellet-Morin I, 2011, BRAIN BEHAV IMMUN, V25, P640, DOI 10.1016/j.bbi.2010.12.020
   Out D, 2012, BRAIN BEHAV IMMUN, V26, P543, DOI 10.1016/j.bbi.2012.01.019
   Pollitt RA, 2007, EUR J EPIDEMIOL, V22, P55, DOI 10.1007/s10654-006-9082-1
   PRINZ RJ, 1979, J APPL BEHAV ANAL, V12, P691, DOI 10.1901/jaba.1979.12-691
   RADLOFF LS, 1991, J YOUTH ADOLESCENCE, V20, P149, DOI 10.1007/BF01537606
   Repetti RL, 2002, PSYCHOL BULL, V128, P330, DOI 10.1037/0033-2909.128.2.330
   Schleifer SJ, 2002, J AM ACAD CHILD PSY, V41, P1054, DOI 10.1097/00004583-200209000-00005
   Schwartz OS, 2014, CLIN PSYCHOL SCI, V2, P272, DOI 10.1177/2167702613505531
   Schwartz OS, 2012, J ABNORM CHILD PSYCH, V40, P59, DOI 10.1007/s10802-011-9542-2
   Schwartz OS, 2011, BEHAV RES THER, V49, P331, DOI 10.1016/j.brat.2011.02.008
   Selye H., 1975, STRESS LIFE
   Sheeber L, 1997, J ABNORM CHILD PSYCH, V25, P333, DOI 10.1023/A:1025768504415
   Sheeber LB, 2007, J ABNORM PSYCHOL, V116, P144, DOI 10.1037/0021-843X.116.1.144
   Shen BJ, 2010, ANN BEHAV MED, V40, P258, DOI 10.1007/s12160-010-9211-7
   Shonkoff JP, 2009, JAMA-J AM MED ASSOC, V301, P2252, DOI 10.1001/jama.2009.754
   Steinberg L, 2001, ANNU REV PSYCHOL, V52, P83, DOI 10.1146/annurev.psych.52.1.83
   Stocker CM, 2007, SOC DEV, V16, P310, DOI 10.1111/j.1467-9507.2007.00386.x
   Taylor SE, 2006, BIOL PSYCHIAT, V60, P819, DOI 10.1016/j.biopsych.2006.03.016
   Whittle S, 2014, DEV COGN NEUROS-NETH, V8, P7, DOI 10.1016/j.dcn.2013.10.006
   Yap MBH, 2008, CHILD DEV, V79, P1415, DOI 10.1111/j.1467-8624.2008.01196.x
   Zeman J, 2007, CLIN PSYCHOL-SCI PR, V14, P377, DOI 10.1111/j.1468-2850.2007.00098.x
   Zorrilla EP, 2001, BRAIN BEHAV IMMUN, V15, P199, DOI 10.1006/brbi.2000.0597
NR 83
TC 11
Z9 12
U1 0
U2 8
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD JUL
PY 2017
VL 36
IS 7
BP 641
EP 651
DI 10.1037/hea0000502
PG 11
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA EY1FP
UT WOS:000403711500003
PM 28530434
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Gutiérrez-Rojas, L
   Pulido, S
   Azanza, JR
   Bernardo, M
   Rojo, L
   Mesa, FJ
   Martínez-Ortega, JM
AF Gutierrez-Rojas, Luis
   Pulido, Susana
   Azanza, Jose R.
   Bernardo, Miguel
   Rojo, Luis
   Mesa, Francisco J.
   Martinez-Ortega, Jose M.
TI Risk factor assessment and counselling for 12 months reduces metabolic
   and cardiovascular risk in overweight or obese patients with
   schizophrenia spectrum disorders: The CRESSOB study
SO ACTAS ESPANOLAS DE PSIQUIATRIA
LA English
DT Article
DE Schizophrenia; Metabolic Syndrome; Overweight; Cardiovascular Disease
ID INDUCED WEIGHT-GAIN; SYNDROME SCALE PANSS; PSYCHOTIC DISORDERS;
   LIFE-STYLE; ANTIPSYCHOTIC-DRUGS; GLOBAL ASSESSMENT; PHYSICAL ILLNESS;
   PEOPLE; OUTPATIENTS; PREVALENCE
AB Background. Metabolic syndrome (MS) and cardiovascular risk factors (CRF) have been associated with patients with schizophrenia. The main objective is to assess the evolution of CRF and prevalence of MS for 12 months in a cohort of overweight patients diagnosed with schizophrenia schizophreniform disorder or schizoaffective disorder in which the recommendations for the assessment and control of metabolic and cardiovascular risk were applied.
   Methods. The Control of Metabolic and Cardiovascular Risk in Patients with Schizophrenia and Overweight (CRESSOB) study is a 12-month, observational, prospective, open-label, multicentre, naturalistic study including 109 community mental health clinics of Spain. The study included a total of 403 patients, of whom we could collect all variables related to CRF and MS in 366-patients. Of these 366 patients, 286 completed the follow-up, (baseline, months 3, 6 and 12) where they underwent a complete physical examination and a blood test (glucose, cholesterol and triglycerides), they were asked about their health-related habits (smoking, diet and exercise) and they were given a series of recommendations to prevent cardiovascular risk and MS.
   Results. A total of 403 patients were included, 63% men, mean age (mean; (SD)) 40.5 (10.5) years. After 12 months, the study showed statistically significant decrease in weight (p<0.0001), waist circumference (p<0.0001), BMI (p<0.0001), blood glucose (p=0.0034), total cholesterol (p<0.0001), HDL cholesterol (p=0.02), LDL cholesterol (p=0.0023) and triglycerides (p=0.0005). There was a significant reduction in the percentage of smokers (p=0.0057) and in the risk of heart disease at 10 years (p=0.0353).
   Conclusion. Overweight patients with schizophrenia who receive appropriate medical care, including CRF monitoring and control of health-related habits experience improvements with regard to most CRFs.
C1 [Gutierrez-Rojas, Luis] San Cecilio Univ Hosp, Psychiat Serv, Granada, Spain.
   [Pulido, Susana; Mesa, Francisco J.] Pfizer GEP, Med Unit, Madrid, Spain.
   [Azanza, Jose R.] Univ Navarra, Univ Hosp, Invest Unit, Dept Pharmacol, E-31080 Pamplona, Spain.
   [Bernardo, Miguel] IDIBAPS, Barcelona, Spain.
   [Bernardo, Miguel] Hosp Clin Barcelona, Barcelona Clin Schizophrenia Unit, Barcelona, Spain.
   [Bernardo, Miguel] Univ Barcelona, Dept Psychiat & Clin Psychobiol, E-08007 Barcelona, Spain.
   [Rojo, Luis] Hosp La Fe, Dept Unit, E-46009 Valencia, Spain.
   [Martinez-Ortega, Jose M.] Univ Granada, Inst Neurosci, Ctr Biomed Res CIBM, Dept Psychiat, Granada, Spain.
   [Martinez-Ortega, Jose M.] Univ Granada, Inst Neurosci, Ctr Biomed Res CIBM, CTS Res Grp 549, Granada, Spain.
C3 Hospital Universitario San Cecilio; Pfizer; Pfizer Spain; University of
   Navarra; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS;
   University of Barcelona; Hospital Clinic de Barcelona; University of
   Barcelona; Hospital Universitari i Politecnic La Fe; University of
   Granada; University of Granada
RP Gutiérrez-Rojas, L (corresponding author), Fac Med, Dept Psychiat, Ave Madrid 11, Granada 18071, Spain.
EM gutierrezrojasl@hotmail.com
RI Mesa, Francisco/KRO-3713-2024; Rojas, Luis/AAI-1110-2021; Rojas,
   Luis/B-8732-2013; Azanza Perea, José Ramón/ABG-1593-2021; Bernardo,
   Miquel/P-3049-2015
OI Azanza Perea, Jose Ramon/0000-0003-3190-622X; Bernardo,
   Miquel/0000-0001-8748-6717; Gutierrez-Rojas, Luis/0000-0003-0082-2189
FU Pfizer
FX This study was sponsored by Pfizer. Pfizer contributed to and approved
   the study design and the final draft of the manuscript. A CRO, European
   Biometrics Institute, was engaged by Pfizer to conduct the study,
   including logistics, monitoring, data management, and statistical
   analysis. Pfizer oversaw the entire process of the study.
CR Allison DB, 1999, AM J PSYCHIAT, V156, P1686
   Allison DB, 2001, J CLIN PSYCHIAT, V62, P22
   Alvarez-Jiménez M, 2008, BRIT J PSYCHIAT, V193, P101, DOI 10.1192/bjp.bp.107.042853
   Andreasen NC, 2005, AM J PSYCHIAT, V162, P441, DOI 10.1176/appi.ajp.162.3.441
   [Anonymous], 2004, J CLIN PSYCHIAT, V65, P267
   [Anonymous], BOD MASS IND BMI
   Arango C, 2008, SCHIZOPHR RES, V104, P1, DOI 10.1016/j.schres.2008.05.009
   Barnett AH, 2007, J PSYCHOPHARMACOL, V21, P357, DOI 10.1177/0269881107075509
   Bobes J, 2007, SCHIZOPHR RES, V90, P162, DOI 10.1016/j.schres.2006.09.025
   Bobes J, 2010, SCHIZOPHR RES, V119, P101, DOI 10.1016/j.schres.2010.02.1030
   Bresee LC, 2010, SCHIZOPHR RES, V117, P75, DOI 10.1016/j.schres.2009.12.016
   Brown S, 1999, PSYCHOL MED, V29, P697, DOI 10.1017/S0033291798008186
   Citrome Leslie, 2005, J Psychopharmacol, V19, P84, DOI 10.1177/0269881105058375
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cohn T, 2004, CAN J PSYCHIAT, V49, P753, DOI 10.1177/070674370404901106
   Coldham EL, 2002, ACTA PSYCHIAT SCAND, V106, P286, DOI 10.1034/j.1600-0447.2002.02437.x
   Daumit GL, 2005, J NERV MENT DIS, V193, P641, DOI 10.1097/01.nmd.0000180737.85895.60
   De Hert M, 2009, EUR PSYCHIAT, V24, P412, DOI 10.1016/j.eurpsy.2009.01.005
   De Hert M, 2011, WORLD PSYCHIATRY, V10, P138
   de Leon J, 2005, J CLIN PSYCHIAT, V66, P1447, DOI 10.4088/JCP.v66n1112
   ENDICOTT J, 1976, ARCH GEN PSYCHIAT, V33, P766
   Faulkner G, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005148.pub2
   First MB, 1996, Structured Clinical Interview for the DSM-IV-TR Axis I Disorders, DOI DOI 10.1037/T07827-000
   Goff DC, 2005, SCHIZOPHR RES, V80, P45, DOI 10.1016/j.schres.2005.08.010
   GORTMAKER SL, 1993, NEW ENGL J MED, V329, P1008, DOI 10.1056/NEJM199309303291406
   Gupta Sanjay, 2003, Am J Ther, V10, P348, DOI 10.1097/00045391-200309000-00007
   Gurpegui M, 2012, PROG NEURO-PSYCHOPH, V37, P169, DOI 10.1016/j.pnpbp.2012.01.014
   Gutiérrez-Rojas L, 2014, ACTAS ESP PSIQUIATRI, V42, P9
   Henderson DC, 2007, J CLIN PSYCHIAT, V68, P18
   Hennekens CH, 2005, AM HEART J, V150, P1115, DOI 10.1016/j.ahj.2005.02.007
   Hermes E, 2011, SCHIZOPHR RES, V128, P166, DOI 10.1016/j.schres.2011.01.022
   Holt RIG, 2004, DIABETIC MED, V21, P515, DOI 10.1111/j.1464-5491.2004.01199.x
   KAY SR, 1987, SCHIZOPHRENIA BULL, V13, P261, DOI 10.1093/schbul/13.2.261
   Li CH, 2014, J NERV MENT DIS, V202, P313, DOI 10.1097/NMD.0000000000000124
   Lieberman JA, 2005, NEW ENGL J MED, V353, P1209, DOI 10.1056/NEJMoa051688
   Loh Catherine, 2006, Ann Clin Psychiatry, V18, P23, DOI 10.1080/10401230500464646
   McCreadie RG, 2003, BRIT J PSYCHIAT, V183, P534, DOI 10.1192/bjp.183.6.534
   Mittal VA, 2011, PSYCHIAT RES, V189, P158, DOI 10.1016/j.psychres.2011.06.006
   Nasrallah HA, 2006, SCHIZOPHR RES, V86, P15, DOI 10.1016/j.schres.2006.06.026
   PERALTA V, 1994, PSYCHIAT RES, V53, P31, DOI 10.1016/0165-1781(94)90093-0
   Prieto L, 2004, CURR MED RES OPIN, V20, P827, DOI 10.1185/030079904125003674
   Rodríguez-Artalejo F, 2006, MED CLIN-BARCELONA, V127, P542, DOI 10.1157/13093733
   Saari KM, 2005, J CLIN PSYCHIAT, V66, P559, DOI 10.4088/JCP.v66n0503
   Saarni SE, 2009, PSYCHOL MED, V39, P801, DOI 10.1017/S0033291708004194
   Ruiz JS, 2008, ACTAS ESP PSIQUIATRI, V36, P251
   Samele C, 2007, SOC PSYCH PSYCH EPID, V42, P117, DOI 10.1007/s00127-006-0135-2
   Schwartz RC, 2007, PSYCHOL REP, V100, P571, DOI 10.2466/PRO.100.2.571-574
   Sicras-Mainar A, 2008, EUR PSYCHIAT, V23, P100, DOI 10.1016/j.eurpsy.2007.07.005
   Simon GE, 2006, ARCH GEN PSYCHIAT, V63, P824, DOI 10.1001/archpsyc.63.7.824
   Suvisaari J, 2008, EUR ARCH PSY CLIN N, V258, P129, DOI 10.1007/s00406-007-0762-y
   Suvisaari JM, 2007, J CLIN PSYCHIAT, V68, P1045, DOI 10.4088/JCP.v68n0711
   Taylor D, 2005, J PSYCHOPHARMACOL, V19, P182, DOI 10.1177/0269881105049039
   Volavka J, 2011, J CLIN PSYCHIAT, V72, P955, DOI 10.4088/JCP.10m06529
   Wahlbeck K, 2001, PSYCHOPHARMACOLOGY, V155, P230, DOI 10.1007/s002130100711
   Weiden PJ, 2004, SCHIZOPHR RES, V66, P51, DOI 10.1016/S0920-9964(02)00498-X
   WILLIAMS A, 1990, HEALTH POLICY, V16, P199
   Wilson PWF, 1998, CIRCULATION, V97, P1837, DOI 10.1161/01.CIR.97.18.1837
NR 57
TC 8
Z9 9
U1 0
U2 8
PU JUAN JOSE LOPEZ-IBOR FOUNDATION
PI MADRID
PA NO 2, MADRID, 28035, SPAIN
SN 1139-9287
EI 1578-2735
J9 ACTAS ESP PSIQUIATRI
JI Actas Esp. Psiquiatri.
PD JAN-FEB
PY 2016
VL 44
IS 1
BP 20
EP 29
PG 10
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA DH0NZ
UT WOS:000372482200003
PM 26905887
DA 2025-06-11
ER

PT J
AU Palomo, I
   Alarcón, M
   Moore-Carrasco, R
   Argilés, JM
AF Palomo, Ivan
   Alarcon, Marcelo
   Moore-Carrasco, Rodrigo
   Argiles, Josep M.
TI Hemostasis alterations in metabolic syndrome (review)
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Review
DE metabolic syndrome; hemostasis; thrombosis
ID LOW-DENSITY-LIPOPROTEIN; PLASMINOGEN-ACTIVATOR INHIBITOR; CARDIOVASCULAR
   RISK-FACTORS; FACTOR PATHWAY INHIBITOR; CORONARY-HEART-DISEASE;
   C-REACTIVE PROTEIN; INSULIN-RESISTANCE; TISSUE FACTOR; ENDOTHELIAL
   DYSFUNCTION; ANTICARDIOLIPIN ANTIBODIES
AB Metabolic syndrome (MS) is characterized by the presence of at least three of the following alterations: enlargement of the waist diameter, higher levels of arterial pressure, low density lipoprotein cholesterol and glycemia, and reduction of high density lipoprotein cholesterol. The prevalence of MS reaches 23% in young adults, a percentage that increases with age. People with MS have a greater risk of suffering from cardiovascular disease (CVD). The physiopathologic alterations now found to exist in MS are diverse; among them is endothelial dysfunction, which triggers atherogenic lesions and hypercoagulability characterized by alterations of the coagulation factors and the regulatory proteins of fibrinolysis such as the plasminogen activator inhibitor (PAI-1). The increase in oxidative stress and/or the reactive oxygen species in patients with MS is partially related to the oxidation state of the lipoproteins, especially of the low density lipoproteins. This fact favors atherogenesis. Moreover, the oxidative stress produces alterations in the production of adipokines, cytokines secreted by the adipose tissues. The abnormality in the transport of lipoprotein diminishes the catabolism of the very low density lipoprotein (VLDL) and increases the catabolism of the high density lipoprotein (HDL), which creates insulin resistance. This process is associated with a lower concentration of adiponectin that in turn regulates the catabolism of VLDL and HDL; consequently increasing the flow of fatty acids from the adipose tissue to the liver and muscles. The proinflammatory cytokines, among them tumor necrosis factor alpha (TNF-alpha), are of great importance in MS regulating different processes and molecules such as PAI-1. PAI-1 is controlled by the group of transcription factors peroxisome proliferator-activated receptor (PPAR), especially by PPAR gamma and alpha ligands. In summary, MS includes multiple alterations related to insulin resistance at several levels: hepatic, muscular, adipose and vascular tissue (endothelium). The exact mechanism that underlies the relationship between MS and CVD are not sufficiently known yet; pathogenic explanations are lacking for the mechanisms relating metabolic factors to insulin resistance and the association with the development of atherosclerosis and thrombosis. MS alterations and the main aspects related to homeostasis alterations are examined in this report.
C1 Univ Talca, Dept Clin Biochem & Immunohematol, Fac Hlth Sci, Talca, Chile.
   Univ Barcelona, Dept Bioquim & Biol Mol, Fac Biol, Barcelona, Spain.
C3 Universidad de Talca; University of Barcelona
RP Palomo, I (corresponding author), Univ Talca, Dept Clin Biochem & Immunohematol, Fac Hlth Sci, Mailbox 747, Talca, Chile.
EM ipalomo@utalca.cl
RI Alarcon, Marcelo/I-5016-2018; Palomo, Iván/I-4321-2018; Moore-Carrasco,
   Rodrigo/AAK-3349-2020; Argiles, Josep/L-5741-2014
OI alarcon, marcelo/0000-0001-7596-5382; Palomo, Ivan/0000-0002-9618-8778;
   Moore-Carrasco, Rodrigo/0000-0003-4870-9660; Argiles, Josep
   M./0000-0003-4683-5428
CR Alexander CM, 2003, DIABETES, V52, P1210, DOI 10.2337/diabetes.52.5.1210
   Amengual O, 1997, BRIT J RHEUMATOL, V36, P964
   Anand SS, 2003, CIRCULATION, V108, P420, DOI 10.1161/01.CIR.0000080884.27358.49
   Aubert H, 2003, J THROMB HAEMOST, V1, P791, DOI 10.1046/j.1538-7836.2003.00147.x
   BARBATO JE, 2005, AM J PHYSL HEART CIR
   Barry OP, 1999, THROMB HAEMOSTASIS, V82, P794, DOI 10.1055/s-0037-1615913
   Barry OP, 1997, J CLIN INVEST, V99, P2118, DOI 10.1172/JCI119385
   Barry OP, 1998, J CLIN INVEST, V102, P136, DOI 10.1172/JCI2592
   Baumgartner-Parzer SM, 2001, EXP CLIN ENDOCR DIAB, V109, pS166, DOI 10.1055/s-2001-18579
   Beckman JA, 2002, JAMA-J AM MED ASSOC, V287, P2570, DOI 10.1001/jama.287.19.2570
   Beltowski J, 2003, MED SCI MONITOR, V9, P55
   BERLINER JA, 1990, J CLIN INVEST, V85, P1260, DOI 10.1172/JCI114562
   Bonetti PO, 2003, ARTERIOSCL THROM VAS, V23, P168, DOI 10.1161/01.ATV.0000051384.43104.FC
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Caine GJ, 2005, CANCER LETT, V219, P163, DOI 10.1016/j.canlet.2004.09.036
   Chu NF, 2001, ATHEROSCLEROSIS, V157, P495, DOI 10.1016/S0021-9150(00)00755-3
   Combes V, 1999, J CLIN INVEST, V104, P93, DOI 10.1172/JCI4985
   Costelli P, 2005, INT J ONCOL, V26, P1663
   Cybulsky MI, 2001, J CLIN INVEST, V107, P1255, DOI 10.1172/JCI11871
   *DIR SERV SAL MAUL, AN EST
   Ferri C, 1997, EXP CLIN ENDOCR DIAB, V105, P38, DOI 10.1055/s-0029-1211794
   FERRIS W, 1995, SOUTH CULT, V1, P431, DOI 10.1353/scu.1995.0043
   Ferroni Patrizia, 2004, Curr Atheroscler Rep, V6, P424, DOI 10.1007/s11883-004-0082-x
   Fletcher Barbara, 2004, J Cardiovasc Nurs, V19, P339
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Franco RF, 2000, HAEMATOLOGICA, V85, P67
   Garrison RJ, 1996, CURR OPIN LIPIDOL, V7, P199, DOI 10.1097/00041433-199608000-00005
   GEORGE JN, 1982, BLOOD, V60, P834
   Giesen PLA, 1999, P NATL ACAD SCI USA, V96, P2311, DOI 10.1073/pnas.96.5.2311
   Grundy SM, 2002, CIRCULATION, V105, P2696, DOI 10.1161/01.CIR.0000020650.86137.84
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   HAMSTEN A, 1987, LANCET, V2, P3
   HAMSTEN A, 1985, NEW ENGL J MED, V313, P1557, DOI 10.1056/NEJM198512193132501
   Hemmrich K, 2003, J APPL PHYSIOL, V95, P1937, DOI 10.1152/japplphysiol.00419.2003
   Hopfner RL, 1999, DIABETOLOGIA, V42, P1383, DOI 10.1007/s001250051308
   Hori Y, 2002, J CLIN ENDOCR METAB, V87, P660, DOI 10.1210/jc.87.2.660
   Hörkkö S, 2001, CIRCULATION, V103, P941
   Hulthe J, 2000, ARTERIOSCL THROM VAS, V20, P2140, DOI 10.1161/01.ATV.20.9.2140
   *I NAC EST, 2000, AN DEM 2000
   JUHANVAGUE I, 1991, DIABETOLOGIA, V34, P457, DOI 10.1007/BF00403280
   JuhanVague I, 1997, THROMB HAEMOSTASIS, V78, P656
   KANNEL WB, 1979, CIRCULATION, V59, P8, DOI 10.1161/01.CIR.59.1.8
   KARIO K, 1995, ARTERIOSCL THROM VAS, V15, P1114, DOI 10.1161/01.ATV.15.8.1114
   KASKI JC, 1995, BRIT HEART J, V74, P620
   Kharbanda RK, 2001, CORONARY ARTERY DIS, V12, P485, DOI 10.1097/00019501-200109000-00007
   KLEMP P, 1988, CLIN EXP IMMUNOL, V74, P254
   Kohler HP, 2000, NEW ENGL J MED, V342, P1792, DOI 10.1056/NEJM200006153422406
   Kopp CW, 2003, OBES RES, V11, P950, DOI 10.1038/oby.2003.131
   Korporaal SJA, 2004, J BIOL CHEM, V279, P52526, DOI 10.1074/jbc.M407407200
   Krum H, 1998, NEW ENGL J MED, V338, P784, DOI 10.1056/NEJM199803193381202
   Kuryliszyn-Moskal Anna, 2004, Pol Merkur Lekarski, V17, P353
   LamonFava S, 1996, ARTERIOSCL THROM VAS, V16, P1509, DOI 10.1161/01.ATV.16.12.1509
   Lansbury AJ, 2002, CEREBROVASC DIS, V14, P153, DOI 10.1159/000065677
   Lemieux S, 2001, CAN J APPL PHYSIOL, V26, P273, DOI 10.1139/h01-018
   Leurs PB, 2002, DIABETES CARE, V25, P1340, DOI 10.2337/diacare.25.8.1340
   Li QDQ, 2001, INT J MOL MED, V7, P527
   Libby P, 2002, CIRCULATION, V105, P1135, DOI 10.1161/hc0902.104353
   LICATA G, 1995, METABOLISM, V44, P1417, DOI 10.1016/0026-0495(95)90140-X
   Liese AD, 1998, EPIDEMIOL REV, V20, P157, DOI 10.1093/oxfordjournals.epirev.a017978
   Lin CP, 2003, INT J CARDIOL, V89, P53, DOI 10.1016/S0167-5273(02)00428-X
   Lopes C, 2003, DIABETOLOGIA, V46, P1284, DOI 10.1007/s00125-003-1170-0
   Mather KJ, 2001, J AM COLL CARDIOL, V37, P1344, DOI 10.1016/S0735-1097(01)01129-9
   Matsuura Eiji, 2004, Clin Dev Immunol, V11, P103, DOI 10.1080/10446670410001722186
   MEADE TW, 1993, LANCET, V342, P1076, DOI 10.1016/0140-6736(93)92062-X
   Meigs JB, 2000, JAMA-J AM MED ASSOC, V283, P221, DOI 10.1001/jama.283.2.221
   Mesri M, 1999, J BIOL CHEM, V274, P23111, DOI 10.1074/jbc.274.33.23111
   Mills JD, 2002, THROMB HAEMOSTASIS, V87, P409
   Morange PE, 2001, THROMB HAEMOSTASIS, V85, P999, DOI 10.1055/s-0037-1615954
   Moreno PR, 2004, J AM COLL CARDIOL, V44, P2293, DOI 10.1016/j.jacc.2004.07.060
   Muscelli E, 1997, J CLIN ENDOCR METAB, V82, P2937, DOI 10.1210/jc.82.9.2937
   Nieuwland R, 1997, CIRCULATION, V96, P3534
   Ohkura N, 2004, ANTIOXID REDOX SIGN, V6, P705, DOI 10.1089/1523086041361686
   Omoto S, 1999, NEPHRON, V81, P271, DOI 10.1159/000045292
   Ouchi N, 2000, CIRCULATION, V102, P1296, DOI 10.1161/01.CIR.102.11.1296
   Palomo I, 2004, CLIN RHEUMATOL, V23, P129, DOI 10.1007/s10067-003-0846-7
   Palomo I, 2003, CLIN EXP HYPERTENS, V25, P517, DOI 10.1081/CEH-120025335
   Palomo I, 2002, J LAB CLIN MED, V140, P336, DOI 10.1067/mlc.2002.128467
   Pereira J, 2002, THROMB HAEMOSTASIS, V87, P905
   Piatti P, 1999, J AM COLL CARDIOL, V34, P1452, DOI 10.1016/S0735-1097(99)00379-4
   Puccetti L, 2005, EUR J CLIN INVEST, V35, P47, DOI 10.1111/j.1365-2362.2005.01446.x
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   RIDKER PM, 1993, LANCET, V341, P1165, DOI 10.1016/0140-6736(93)90998-V
   Sajadi S, 2003, DRUG NEWS PERSPECT, V16, P363, DOI 10.1358/dnp.2003.16.6.829308
   Sakkinen PA, 2000, AM J EPIDEMIOL, V152, P897, DOI 10.1093/aje/152.10.897
   Sakurai K, 2003, J PHARMACOL SCI, V91, P182
   Samad F, 1997, MOL MED, V3, P37, DOI 10.1007/BF03401666
   Samad F, 2001, BLOOD, V98, P3353, DOI 10.1182/blood.V98.12.3353
   Skurk T, 2004, INT J OBESITY, V28, P1357, DOI 10.1038/sj.ijo.0802778
   Sobel BE, 1998, CIRCULATION, V97, P2213, DOI 10.1161/01.CIR.97.22.2213
   STAMLER J, 1993, DIABETES CARE, V16, P434, DOI 10.2337/diacare.16.2.434
   STEMME S, 1995, P NATL ACAD SCI USA, V92, P3893, DOI 10.1073/pnas.92.9.3893
   Su-Shing Chen, 1989, International Journal of Neural Systems, V1, P95, DOI 10.1142/S0129065789000517
   THOMPSON SG, 1995, NEW ENGL J MED, V332, P635, DOI 10.1056/NEJM199503093321003
   Trayhurn P, 2001, P NUTR SOC, V60, P329, DOI 10.1079/PNS200194
   VAARALA O, 1995, CIRCULATION, V91, P23, DOI 10.1161/01.CIR.91.1.23
   Venugopal SK, 2005, CURR OPIN NEPHROL HY, V14, P33, DOI 10.1097/00041552-200501000-00006
   Verma S, 2002, CIRCULATION, V105, P546, DOI 10.1161/hc0502.104540
   Viles-Gonzalez JF, 2004, J CARDIOVASC PHARM, V43, P669, DOI 10.1097/00005344-200405000-00009
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Westra J, 2005, INT IMMUNOPHARMACOL, V5, P1259, DOI 10.1016/j.intimp.2005.03.005
   Witkowska AM, 2004, EUR CYTOKINE NETW, V15, P91
   Womack CJ, 2001, MED SCI SPORT EXER, V33, P214
   YANAGISAWA M, 1988, NATURE, V332, P411, DOI 10.1038/332411a0
   Yudkin JS, 1999, ARTERIOSCL THROM VAS, V19, P972, DOI 10.1161/01.ATV.19.4.972
NR 104
TC 71
Z9 76
U1 0
U2 3
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD NOV
PY 2006
VL 18
IS 5
BP 969
EP 974
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 097WE
UT WOS:000241479300022
PM 17016629
DA 2025-06-11
ER

PT J
AU Das, UN
AF Das, Undurti N.
TI Cytokines, angiogenic, and antiangiogenic factors and bioactive lipids
   in preeclampsia
SO NUTRITION
LA English
DT Review
DE Preeclampsia; Lipoxins; Oxidative stress; 2-Methoxyestradiol;
   Polyunsaturated fatty acids; Vascular endothelial growth factor;
   Endoglin; Soluble fms-like tyrosine kinase 1
ID ENDOTHELIAL GROWTH-FACTOR; NITRIC-OXIDE SYNTHASE; POLYUNSATURATED
   FATTY-ACIDS; TRIGGERED-LIPOXIN A(4); ANGIOTENSIN-ALDOSTERONE SYSTEM;
   CATECHOL-O-METHYLTRANSFERASE; PRO-INFLAMMATORY CYTOKINES;
   CONGESTIVE-HEART-FAILURE; METABOLIC SYNDROME-X; OXIDATIVE STRESS
AB Preeclampsia is a low-grade systemic inflammatory condition in which oxidative stress and endothelial dysfunction occurs. Plasma levels of soluble receptor for vascular endothelial growth factor (VEGFR)-1, also known as sFlt1 (soluble fms-like tyrosine kinase 1), an antiangiogenic factor have been reported to be elevated in preeclampsia. It was reported that pregnant mice deficient in catechol-O-methyltransferase (COMT) activity show a preeclampsia-like phenotype due to a deficiency or absence of 2-methoxyoestradiol (2-ME), a natural metabolite of estradiol that is elevated during the third trimester of normal human pregnancy. Additionally, autoantibodies (AT1-AAs) that bind and activate the angiotensin II receptor type 1 a (AT1 receptor) also have a role in preeclampsia. None of these abnormalities are consistently seen in all the patients with preeclampsia and some of them are not specific to pregnancy. Preeclampsia could occur due to an imbalance between pro- and antiangiogenic factors. VEGF, an angiogenic factor, is necessary for the transport of polyunsaturated fatty acids (PUFAs) to endothelial cells. Hence reduced VEGF levels decrease the availability of PUFAs to endothelial cells. This leads to a decrease in the formation of anti-inflammatory and angiogenic factors: lipoxins, resolvins, protectins, and maresins from PUFAs. Lipoxins, resolvins, protectins, maresins, and PUFAs suppress insulin resistance; activation of leukocytes, platelets, and macrophages; production of interleukin-6 and tumor necrosis factor-a; and oxidative stress and endothelial dysfunction; and enhance production of prostacyclin and nitric oxide (NO). Estrogen enhances the formation of lipoxin A(4) and NO. PUFAs also augment the production of NO and inhibit the activity of angiotensin-converting enzyme and antagonize the actions of angiotensin II. Thus, PUFAs can prevent activation of angiotensin II receptor type 1 a (AT1 receptor). Patients with preeclampsia have decreased plasma phospholipid concentrations of arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), the precursors of lipoxins (from AA), resolvins (from EPA and DHA), and protectins (from DHA) and prostaglandin E-1 (PGE(1) from DGLA: dihomo-gamma-linolenic acid) and prostacyclin (PGI(2) derived from AA). Based on these evidences, it is proposed that preeclampsia may occur due to deficiency of PUFAs and their anti-inflammatory products: lipoxins, resolvins, protectins, and maresins. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Das, Undurti N.] UND Life Sci, Federal Way, WA 98003 USA.
   [Das, Undurti N.] GVP Hosp & BioSci Res Ctr, Dept Med, Visakhapatnam, Andhra Pradesh, India.
RP Das, UN (corresponding author), UND Life Sci, Federal Way, WA 98003 USA.
EM undurti@hotmail.com
RI Das, Undurti/A-7918-2009
FU Department of Biotechnology, New Delhi; Department of Science and
   Technology under Intensification of Research in High Priority Areas
   (IRPHA) [IR/SO/LU/03/2008/1]; Defence Research and Development
   Organisation, New Delhi [TC/2519/INM - 03/2011/CARS, INM-311]
FX The author is in receipt of Ramalingaswami Fellowship of the Department
   of Biotechnology, New Delhi during the tenure of this study. This work
   was supported by grants from the Department of Science and Technology
   (No. IR/SO/LU/03/2008/1) under Intensification of Research in High
   Priority Areas (IRPHA), and Defence Research and Development
   Organisation, New Delhi {(TC/2519/INM - 03/2011/CARS) under R&D Project
   INM-311) to the author.
CR Abo-Elmatty DM, 2012, INDIAN J CLIN BIOCHE, V27, P379, DOI 10.1007/s12291-012-0226-7
   Ahmed A, 2009, BIOCHEM SOC T, V37, P1237, DOI 10.1042/BST0371237
   Al-Jameil Noura, 2014, J Clin Med Res, V6, P1, DOI 10.4021/jocmr1682w
   Alba-Loureiro TC, 2004, INFLAMM RES, V53, P658, DOI 10.1007/s00011-004-1308-7
   Anim-Nyame N, 2004, GYNECOL ENDOCRINOL, V18, P117, DOI 10.1080/09513590410001667832
   Bazavilvaso-Rodríguez MA, 2011, ARCH MED RES, V42, P195, DOI 10.1016/j.arcmed.2011.04.011
   Araujo M, 2014, ANTIOXID REDOX SIGN, V20, P74, DOI 10.1089/ars.2013.5259
   ARISAKA M, 1986, J PEDIATR GASTR NUTR, V5, P878, DOI 10.1097/00005176-198611000-00009
   Arnold C, 2010, PHARMACOL REP, V62, P536, DOI 10.1016/S1734-1140(10)70311-X
   ARRAZOLA A, 1991, AM J PHYSIOL, V261, pH134, DOI 10.1152/ajpheart.1991.261.1.H134
   AUGUST P, 1990, AM J OBSTET GYNECOL, V163, P1612, DOI 10.1016/0002-9378(90)90639-O
   Baker N, 2009, J IMMUNOL, V182, P3819, DOI 10.4049/jimmunol.0803175
   Baker PRS, 2005, J BIOL CHEM, V280, P42464, DOI 10.1074/jbc.M504212200
   BARNEA ER, 1988, AM J PERINAT, V5, P121, DOI 10.1055/s-2007-999669
   Belotto MF, 2010, CLIN EXP IMMUNOL, V162, P237, DOI 10.1111/j.1365-2249.2010.04240.x
   Benyo DF, 2001, J CLIN ENDOCR METAB, V86, P2505, DOI 10.1210/jc.86.6.2505
   Bernardi F, 2008, J OBSTET GYNAECOL RE, V34, P957, DOI 10.1111/j.1447-0756.2008.00860.x
   Börgeson E, 2012, FASEB J, V26, P4287, DOI 10.1096/fj.12-208249
   Bouloumié A, 1999, CARDIOVASC RES, V41, P773, DOI 10.1016/S0008-6363(98)00228-4
   Braekke K, 2006, PEDIATR RES, V60, P560, DOI 10.1203/01.pdr.0000242299.01219.6a
   BRATT J, 1995, ARTHRITIS RHEUM, V38, P768, DOI 10.1002/art.1780380609
   Brennan EP, 2013, J AM SOC NEPHROL, V24, P627, DOI 10.1681/ASN.2012060550
   Brown NJ, 2008, HYPERTENSION, V51, P161, DOI 10.1161/HYPERTENSIONAHA.107.095489
   Bussen SS, 1998, ACTA OBSTET GYN SCAN, V77, P609, DOI 10.1034/j.1600-0412.1998.770606.x
   CATELLA F, 1990, P NATL ACAD SCI USA, V87, P5893, DOI 10.1073/pnas.87.15.5893
   Cezar-De-Mello PFT, 2008, BRIT J PHARMACOL, V153, P956, DOI 10.1038/sj.bjp.0707650
   Cezar-de-Mello PFT, 2006, ONCOGENE, V25, P122, DOI 10.1038/sj.onc.1209002
   Chamarthi B, 2011, AM J HYPERTENS, V24, P1143, DOI 10.1038/ajh.2011.113
   CHASE HP, 1979, J PEDIATR-US, V94, P185, DOI 10.1016/S0022-3476(79)80819-7
   Chavarría ME, 2003, AM J OBSTET GYNECOL, V188, P986, DOI 10.1067/mob.2003.203
   Chiang MH, 2009, J BIOL CHEM, V284, P17411, DOI 10.1074/jbc.M109.016170
   Chiang N, 2005, PROSTAG LEUKOTR ESS, V73, P163, DOI 10.1016/j.plefa.2005.05.003
   Conrad KP, 1998, AM J REPROD IMMUNOL, V40, P102
   Das U. N., 1994, Journal of Nutritional Medicine, V4, P149, DOI 10.3109/13590849409034550
   Das U N, 2006, J Assoc Physicians India, V54, P133
   Das U. N., 1992, Journal of Nutritional Medicine, V3, P117, DOI 10.3109/13590849208997969
   Das UN, 2011, MOLECULAR BASIS OF HEALTH AND DISEASE, P1, DOI 10.1007/978-94-007-0495-4
   Das UN, 2002, EXP BIOL MED, V227, P989, DOI 10.1177/153537020222701106
   Das UN, 2002, NUTRITION, V18, P430, DOI 10.1016/S0899-9007(01)00747-X
   DAS UN, 1995, PROSTAG LEUKOTR ESS, V52, P387, DOI 10.1016/0952-3278(95)90066-7
   Das UN, 2005, MED SCI MONITOR, V11
   Das UN, 2010, MED SCI MONITOR, V16, pLE11
   Das UN, 2006, CURR PHARM BIOTECHNO, V7, P467, DOI 10.2174/138920106779116856
   Das UN, 2013, AM J OBSTET GYNECOL, V209, P497, DOI 10.1016/j.ajog.2013.06.014
   Das UN, 2013, PROSTAG LEUKOTR ESS, V88, P201, DOI 10.1016/j.plefa.2012.11.009
   Das UN, 2013, NUTRITION, V29, P1, DOI 10.1016/j.nut.2012.02.003
   Das UN, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-76
   Das UN, 2010, EXPERT REV ENDOCRINO, V5, P577, DOI [10.1586/eem.10.19, 10.1586/EEM.10.19]
   Das UN, 2013, CLIN LIPIDOL, V8, P465, DOI 10.2217/CLP.13.32
   DELACRETAZ E, 1995, CLIN SCI, V88, P607, DOI 10.1042/cs0880607
   Dona M, 2008, BLOOD, V112, P848, DOI 10.1182/blood-2007-11-122598
   Dulak J, 2003, ANTIOXID REDOX SIGN, V5, P123, DOI 10.1089/152308603321223612
   Dulak J, 2000, ARTERIOSCL THROM VAS, V20, P659, DOI 10.1161/01.ATV.20.3.659
   Duley L, 2007, BJOG-INT J OBSTET GY, V114, P300, DOI 10.1111/j.1471-0528.2006.01166.x
   Duval M, 2003, J BIOL CHEM, V278, P20091, DOI 10.1074/jbc.M301410200
   Dy J, 2008, PLACENTA, V29, P193, DOI 10.1016/j.placenta.2007.10.010
   DZAU VJ, 1987, AM J CARDIOL, V60, P1101, DOI 10.1016/0002-9149(87)90361-4
   Elsenberg EHAM, 2013, ATHEROSCLEROSIS, V231, P346, DOI 10.1016/j.atherosclerosis.2013.09.036
   ERTEL W, 1991, ANN SURG, V214, P141, DOI 10.1097/00000658-199108000-00008
   Feig DS, 2013, PLOS MED, V10, DOI 10.1371/journal.pmed.1001425
   Fels J, 2010, BBA-MOL BASIS DIS, V1802, P1193, DOI 10.1016/j.bbadis.2010.03.006
   Fels J, 2010, PFLUG ARCH EUR J PHY, V460, P915, DOI 10.1007/s00424-010-0871-8
   Funder JW, 2004, MOL CELL ENDOCRINOL, V217, P263, DOI 10.1016/j.mce.2003.10.054
   Gennari-Moser C, 2013, HYPERTENSION, V61, P1111, DOI 10.1161/HYPERTENSIONAHA.111.00575
   George EM, 2013, CURR OPIN NEPHROL HY, V22, P156, DOI 10.1097/MNH.0b013e32835d19f7
   Gil-Villa AM, 2012, PROSTAG LEUKOTR ESS, V87, P127, DOI 10.1016/j.plefa.2012.08.003
   GOESCHEN K, 1993, J PERINAT MED, V21, P481, DOI 10.1515/jpme.1993.21.6.481
   Gutierrez AD, 2012, ATHEROSCLEROSIS, V223, P204, DOI 10.1016/j.atherosclerosis.2012.04.016
   Hagberg CE, 2010, NATURE, V464, P917, DOI 10.1038/nature08945
   Hahn EL, 1998, J TRAUMA, V44, P777, DOI 10.1097/00005373-199805000-00006
   Hamby ME, 2006, GLIA, V54, P566, DOI 10.1002/glia.20411
   Hanke CJ, 2000, HYPERTENSION, V35, P324, DOI 10.1161/01.HYP.35.1.324
   Harsem NK, 2006, EUR J OBSTET GYN R B, V128, P209, DOI 10.1016/j.ejogrb.2005.11.014
   Heger J, 2011, J CELL PHYSIOL, V226, P2683, DOI 10.1002/jcp.22619
   Hennessy A, 1999, J IMMUNOL, V163, P3491
   HIGASHI Y, 1995, J CLIN ENDOCR METAB, V80, P2198, DOI 10.1210/jc.80.7.2198
   HOLMES PV, 1988, EXPERIENTIA, V44, P772, DOI 10.1007/BF01959160
   HUANG PL, 1995, NATURE, V377, P239, DOI 10.1038/377239a0
   Irani RA, 2011, SEMIN NEPHROL, V31, P47, DOI 10.1016/j.semnephrol.2010.10.005
   Jain A, 2014, LAB INVEST, V94, P873, DOI 10.1038/labinvest.2014.76
   Jayashree B, 2014, MOL CELL BIOCHEM, V388, P203, DOI 10.1007/s11010-013-1911-4
   Jia LX, 2012, FRONT BIOSCI-LANDMRK, V17, P221, DOI 10.2741/3923
   Jiang HL, 2013, AM J HYPERTENS, V26, P271, DOI 10.1093/ajh/hps011
   Jiang JJ, 2011, AM J PHYSIOL-LUNG C, V301, pL361, DOI 10.1152/ajplung.00464.2010
   Johnson RD, 1998, AM J OBSTET GYNECOL, V178, P54, DOI 10.1016/S0002-9378(98)70626-X
   Kaaja R, 2004, METABOLISM, V53, P1433, DOI 10.1016/j.metabol.2004.06.009
   Kanasaki K, 2008, NATURE, V453, P1117, DOI 10.1038/nature06951
   Kitada M, 2011, DIABETES, V60, P634, DOI 10.2337/db10-0386
   Kleinrouweler CE, 2012, BJOG-INT J OBSTET GY, V119, P778, DOI 10.1111/j.1471-0528.2012.03311.x
   Klockenbusch W, 2000, GYNECOL OBSTET INVES, V50, P103, DOI 10.1159/000010292
   Knight M, 2007, BJOG-INT J OBSTET GY, V114, P1072, DOI 10.1111/j.1471-0528.2007.01423.x
   Knöfler M, 2012, PLACENTA, V33, pS55, DOI 10.1016/j.placenta.2011.09.019
   Kohno H, 2007, INT J CANCER, V121, P506, DOI 10.1002/ijc.22736
   Kumar C A, 2000, Med Sci Monit, V6, P901
   Kumar K. Vijay, 1994, Journal of Nutritional Medicine, V4, P33, DOI 10.3109/13590849409034538
   Kumar KV, 1997, P SOC EXP BIOL MED, V214, P374, DOI 10.3181/00379727-214-44106
   KUMAR KV, 1993, FREE RADICAL RES COM, V19, P59, DOI 10.3109/10715769309056499
   Kusche-Vihrog K, 2011, HYPERTENSION, V57, P231, DOI 10.1161/HYPERTENSIONAHA.110.163444
   LAHERA V, 1986, PROSTA LEUKOTR MED, V24, P35, DOI 10.1016/0262-1746(86)90204-0
   Lan CCE, 2013, DIABETES, V62, P2530, DOI 10.2337/db12-1714
   Langer B, 1998, OBSTET GYNECOL, V91, P196, DOI 10.1016/S0029-7844(97)00660-1
   Lee CG, 2004, NAT MED, V10, P1095, DOI 10.1038/nm1105
   Lee HJ, 2013, INT J BIOCHEM CELL B, V45, P2801, DOI 10.1016/j.biocel.2013.09.018
   Levine RJ, 2006, NEW ENGL J MED, V355, P992, DOI 10.1056/NEJMoa055352
   Levine RJ, 2004, NEW ENGL J MED, V350, P672, DOI 10.1056/NEJMoa031884
   Lewis G, 2001, WHY MOTH DIE 1997 99, P90
   Li F, 2012, J AM SOC NEPHROL, V23, P652, DOI 10.1681/ASN.2011040369
   Ligthart S, 2014, ARTERIOSCL THROM VAS, V34, P2695, DOI 10.1161/ATVBAHA.114.304306
   Lin F, 2012, REPROD TOXICOL, V34, P677, DOI 10.1016/j.reprotox.2012.09.009
   Liu HS, 1998, INT J GYNECOL OBSTET, V63, P1, DOI 10.1016/S0020-7292(98)00101-5
   Liu SJ, 2009, PHARMACOLOGY, V84, P17, DOI 10.1159/000221379
   Lopez-Jaramillo Patricio, 2008, Ther Adv Cardiovasc Dis, V2, P261, DOI 10.1177/1753944708092277
   Lowe DT, 2000, NITRIC OXIDE-BIOL CH, V4, P441, DOI 10.1006/niox.2000.0296
   Lubrano Valter, 2015, World J Exp Med, V5, P21, DOI 10.5493/wjem.v5.i1.21
   Mackay VA, 2012, HYPERTENSION, V60, P1078, DOI 10.1161/HYPERTENSIONAHA.112.197897
   MAHFOUZ MM, 1989, LIPIDS, V24, P727, DOI 10.1007/BF02535212
   Makwana M, 2007, J NEUROSCI, V27, P11201, DOI 10.1523/JNEUROSCI.2255-07.2007
   Malatyalioglu E, 2000, J Matern Fetal Med, V9, P173
   Marcheselli VL, 2010, PROSTAG LEUKOTR ESS, V82, P27, DOI 10.1016/j.plefa.2009.10.010
   MCVEIGH GE, 1993, DIABETOLOGIA, V36, P33, DOI 10.1007/BF00399090
   Mehendale S, 2008, INT J GYNECOL OBSTET, V100, P234, DOI 10.1016/j.ijgo.2007.08.011
   Mills JL, 1999, JAMA-J AM MED ASSOC, V282, P356, DOI 10.1001/jama.282.4.356
   MOORE TJ, 1981, HYPERTENSION, V3, P168, DOI 10.1161/01.HYP.3.2.168
   Murohara T, 1998, CIRCULATION, V97, P99, DOI 10.1161/01.CIR.97.1.99
   Nascimento-Silva V, 2007, THROMB HAEMOSTASIS, V97, P88, DOI 10.1160/TH06-06-0315
   Ni Juan, 2008, Zhonghua Fu Chan Ke Za Zhi, V43, P325
   Noris M, 2004, HYPERTENSION, V43, P614, DOI 10.1161/01.HYP.0000116220.39793.c9
   OGBURN PL, 1984, AM J OBSTET GYNECOL, V148, P5, DOI 10.1016/S0002-9378(84)80023-X
   Okuda Y, 1997, BIOCHEM BIOPH RES CO, V232, P487, DOI 10.1006/bbrc.1997.6328
   Paarlberg KM, 1998, AM J OBSTET GYNECOL, V179, P1559, DOI 10.1016/S0002-9378(98)70024-9
   PAKRASI PL, 1985, PROSTAG OTH LIPID M, V29, P481, DOI 10.1016/0090-6980(85)90106-6
   PATEL L, 1989, PROSTAG OTH LIPID M, V38, P615, DOI 10.1016/0090-6980(89)90044-0
   Patel P, 2000, J INVEST MED, V48, P403
   Paul-Clark MJ, 2004, J EXP MED, V200, P69, DOI 10.1084/jem.20040566
   Peeters ACTM, 2001, EUR J CLIN INVEST, V31, P31, DOI 10.1046/j.1365-2362.2001.00743.x
   PUNZENGRUBER C, 1986, AM J CARDIOL, V57, P619, DOI 10.1016/0002-9149(86)90846-5
   Qiu Chunfang, 2006, Archives of Gynecology and Obstetrics, V274, P97, DOI 10.1007/s00404-006-0140-4
   Rajesh KG, 2011, SINGAP MED J, V52, P283
   RAMSAMMY LS, 1993, LIPIDS, V28, P433, DOI 10.1007/BF02535942
   RATHAUS M, 1982, NEPHRON, V31, P337, DOI 10.1159/000182677
   Redman CW, 2005, SCIENCE, V308, P1592, DOI 10.1126/science.1111726
   Romano M, 2002, LAB INVEST, V82, P1253, DOI 10.1097/01.LAB.0000028823.53486.4A
   Romanowicz Lech, 2009, Atherosclerosis, V204, pe44, DOI 10.1016/j.atherosclerosis.2008.11.008
   Royal College of Obstetricians and Gynaecologists, 2006, MAN SEV PREECL ECL 2
   Royal College of Obstetricians and Gynaecologists, PREECL STUD GROUP ST
   Russell R, 2011, FASEB J, V25, P4326, DOI 10.1096/fj.11-187658
   Sandrim VC, 2008, HYPERTENSION, V52, P402, DOI 10.1161/HYPERTENSIONAHA.108.115006
   Sata F, 2006, PHARMACOGENET GENOM, V16, P775, DOI 10.1097/01.fpc.0000230116.49452.c0
   Schmidt A, 2003, CARDIOVASC RES, V58, P671, DOI 10.1016/S0008-6363(03)00322-5
   Schwab JM, 2007, NATURE, V447, P869, DOI 10.1038/nature05877
   Scioscia M, 2009, J REPROD IMMUNOL, V82, P100, DOI 10.1016/j.jri.2009.04.009
   SELIGMAN SP, 1994, AM J OBSTET GYNECOL, V171, P944, DOI 10.1016/S0002-9378(94)70064-8
   Shojaati K, 2004, KIDNEY INT, V66, P2322, DOI 10.1111/j.1523-1755.2004.66031.x
   Siddiqui AH, 2013, HYPERTENSION, V61, P472, DOI 10.1161/HYPERTENSIONAHA.111.00157
   SMITH AJ, 1995, BRIT J OBSTET GYNAEC, V102, P900, DOI 10.1111/j.1471-0528.1995.tb10879.x
   Solomon CG, 2004, NEW ENGL J MED, V350, P641, DOI 10.1056/NEJMp038241
   Stekkinger E, 2013, BJOG-INT J OBSTET GY, V120, P979, DOI 10.1111/1471-0528.12189
   Strong VEM, 2000, SHOCK, V14, P374
   Suzuki Y, 2002, J PHYSIOL-LONDON, V545, P269, DOI 10.1113/jphysiol.2002.022384
   Szpera-Gozdziewicz A, 2014, FRONT BIOSCI-LANDMRK, V19, P734, DOI 10.2741/4240
   Takeda Y, 1997, HYPERTENSION, V30, P953, DOI 10.1161/01.HYP.30.4.953
   Takyar S, 2013, J EXP MED, V210, P1993, DOI 10.1084/jem.20121200
   Tamaoki J, 1995, EUR J PHARMACOL, V287, P233, DOI 10.1016/0014-2999(95)00490-4
   Tateishi N, 2015, LIPIDS HEALTH DIS, V14, DOI 10.1186/1476-511X-14-3
   Ten Broeke R, 2006, RESP RES, V7, DOI 10.1186/1465-9921-7-58
   Uhlmann S, 2001, MICROVASC RES, V62, P179, DOI 10.1006/mvre.2001.2334
   Vassalle C, 2012, CLIN CHEM LAB MED, V50, P1463, DOI 10.1515/cclm-2011-0919
   Veas CJ, 2011, J MATERN-FETAL NEO M, V24, P1371, DOI 10.3109/14767058.2011.556204
   Velzing-Aarts FV, 1999, AM J CLIN NUTR, V69, P293
   Venkatesha S, 2006, NAT MED, V12, P642, DOI 10.1038/nm1429
   Verdonk K, 2014, CLIN SCI, V126, P537, DOI 10.1042/CS20130455
   Virdis A, 2013, HYPERTENSION, V62, P337, DOI 10.1161/HYPERTENSIONAHA.111.00995
   WALSH SW, 1986, SEMIN PERINATOL, V10, P334
   Walter A, 2008, J VASC RES, V45, P386, DOI 10.1159/000121408
   Wang JF, 2010, J HUAZHONG U SCI-MED, V30, P767, DOI 10.1007/s11596-010-0655-6
   Wang JJ, 2010, DIABETES, V59, P2297, DOI 10.2337/db09-1420
   Wang YP, 2011, J NEUROINFLAMM, V8, DOI 10.1186/1742-2094-8-95
   Wang YP, 2005, HYPERTENS PREGNANCY, V24, P235, DOI 10.1080/10641950500281118
   WANG YP, 1991, AM J OBSTET GYNECOL, V164, P812, DOI 10.1016/0002-9378(91)90521-R
   Weinberger M H, 1976, Perspect Nephrol Hypertens, V5, P263
   Williams G, 1996, AM J PHYSIOL-REG I, V270, pR145, DOI 10.1152/ajpregu.1996.270.1.R145
   WOODWORTH SH, 1994, J CLIN ENDOCR METAB, V78, P1225, DOI 10.1210/jc.78.5.1225
   Xu ZY, 2014, FERTIL STERIL, V102, P282, DOI 10.1016/j.fertnstert.2014.03.056
   Xu ZY, 2012, AM J REPROD IMMUNOL, V67, P491, DOI 10.1111/j.1600-0897.2011.01101.x
   Yoo SA, 2008, MEDIAT INFLAMM, V2008, DOI 10.1155/2008/129873
   Zhang RL, 2003, CIRC RES, V92, P308, DOI 10.1161/01.RES.0000056757.93432.8C
   Zhou CC, 2008, NAT MED, V14, P855, DOI 10.1038/nm.1856
NR 187
TC 39
Z9 43
U1 0
U2 29
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD SEP
PY 2015
VL 31
IS 9
BP 1083
EP 1095
DI 10.1016/j.nut.2015.03.013
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CO8CQ
UT WOS:000359393000003
PM 26233865
DA 2025-06-11
ER

PT J
AU Stepaniuk, A
   Baran, A
   Flisiak, I
AF Stepaniuk, A.
   Baran, A.
   Flisiak, I.
TI Kynurenine Pathway in Psoriasis-a Promising Link?
SO DERMATOLOGY AND THERAPY
LA English
DT Review
DE Kynurenine; Kynurenine pathway; Psoriasis; Quinolinic acid
ID RISK
AB Psoriasis is a common dermatosis which affects the patient's skin and general well-being because of its link to diseases such as depression, kidney disease and metabolic syndrome. Pathogenesis remains unknown; however, genetic, environmental and immunological factors seem to play a role in the development of the disease. Due to a lack of complete understanding of the psoriasis pathology, effective treatment is yet to be developed. The kynurenine pathway is one of the ways amino acid tryptophan is metabolised. In comorbidities typical for psoriasis such as chronic kidney disease, depression and atherosclerotic alterations in the activation of the kynurenine pathway were observed, which were mainly characterised by higher activity compared to that in healthy individuals. However, the kynurenine pathway has not been thoroughly studied among patients with psoriasis even though increased levels of l-kynurenine, one of the enzymes in the kynurenine pathway, were found in psoriatic skin lesions. Given the unknown pathogenesis of the disease, this finding seems to be a potential new field of study and shows a possible link between psoriasis and its comorbidities that could also lead to novel effective treatment for this chronic condition.
C1 [Stepaniuk, A.; Baran, A.; Flisiak, I.] Med Univ Bialystok, Dept Dermatol & Venerol, Zurawia 14, PL-15540 Bialystok, Poland.
C3 Medical University of Bialystok
RP Stepaniuk, A (corresponding author), Med Univ Bialystok, Dept Dermatol & Venerol, Zurawia 14, PL-15540 Bialystok, Poland.
EM stepaniukanna@gmail.com
RI BARAN, ALPER/JCO-3007-2023; Flisiak, Iwona/R-5874-2018
OI Stepaniuk, Anna/0000-0003-1414-4569
CR Abuabara K, 2010, BRIT J DERMATOL, V163, P586, DOI 10.1111/j.1365-2133.2010.09941.x
   Al-Mazeedi K, 2006, INT J DERMATOL, V45, P418, DOI 10.1111/j.1365-4632.2006.02502.x
   Ala M, 2022, INT J TRYPTOPHAN RES, V15, DOI 10.1177/11786469221096643
   Alidrisi HA, 2019, CUREUS J MED SCIENCE, V11, DOI 10.7759/cureus.4269
   Alvarez BD, 2021, PHARMACOL BIOCHEM BE, V209, DOI 10.1016/j.pbb.2021.173243
   Bu J, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.880201
   Chen DM, 2021, FRONT MICROBIOL, V12, DOI 10.3389/fmicb.2021.643449
   Chen LM, 2021, J NEUROINFLAMM, V18, DOI 10.1186/s12974-021-02175-2
   Clement CC, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-24785-3
   Dahl J, 2015, PSYCHONEUROENDOCRINO, V56, P12, DOI 10.1016/j.psyneuen.2015.02.011
   Davis I, 2015, EXPERT REV NEUROTHER, V15, P719, DOI 10.1586/14737175.2015.1049999
   De Francesco MA, 2022, VACCINES-BASEL, V10, DOI 10.3390/vaccines10020244
   Dubreuil M, 2014, RHEUMATOLOGY, V53, P346, DOI 10.1093/rheumatology/ket343
   Dudzinska E, 2019, THER ADV GASTROENTER, V12, DOI 10.1177/1756284819881304
   Fried RG, 2005, DERMATOL CLIN, V23, P657, DOI 10.1016/j.det.2005.05.014
   Fu Y, 2018, JAMA DERMATOL, V154, P1417, DOI 10.1001/jamadermatol.2018.3631
   Fujii K, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21155515
   Gáspár R, 2022, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.768560
   Gisondi P, 2018, CLIN DERMATOL, V36, P21, DOI 10.1016/j.clindermatol.2017.09.005
   González-Parra E, 2016, ACTAS DERMO-SIFILOGR, V107, P823, DOI 10.1016/j.ad.2016.05.009
   GUPTA MA, 1993, INT J DERMATOL, V32, P188, DOI 10.1111/j.1365-4362.1993.tb02790.x
   Harden JL, 2016, J ALLERGY CLIN IMMUN, V137, P1830, DOI 10.1016/j.jaci.2015.09.055
   Hestad K, 2022, BIOMOLECULES, V12, DOI 10.3390/biom12070998
   HOLSKEN S, 2021, ACTA DERM-VENEREOL, V101, DOI 10.2340/actadv.v101.565
   Hughes TD, 2022, MOLECULES, V27, DOI 10.3390/molecules27010273
   Masson W, 2020, ADV THER, V37, P2017, DOI 10.1007/s12325-020-01346-6
   Nisa N, 2010, INDIAN J DERMATOL VE, V76, P662, DOI 10.4103/0378-6323.72462
   Nowowiejska J., 2020, PRZ DERMATOL, V107, P273
   Nowowiejska J, 2022, FRONT MOL NEUROSCI, V15, DOI 10.3389/fnmol.2022.917751
   Nowowiejska J, 2022, METABOLITES, V12, DOI 10.3390/metabo12090833
   Paul ER, 2022, BRAIN BEHAV IMMUN, V101, P136, DOI 10.1016/j.bbi.2022.01.002
   Pedersen ER, 2015, ARTERIOSCL THROM VAS, V35, P455, DOI 10.1161/ATVBAHA.114.304674
   Pires AS, 2022, INT J TRYPTOPHAN RES, V15, DOI 10.1177/11786469221126063
   Sanders KM, 2018, NEUROSCI BIOBEHAV R, V87, P17, DOI 10.1016/j.neubiorev.2018.01.009
   de Oliveira MDSP, 2015, AN BRAS DERMATOL, V90, P9, DOI 10.1590/abd1806-4841.20153038
   Savitz J, 2020, MOL PSYCHIATR, V25, P131, DOI 10.1038/s41380-019-0414-4
   Schuster B, 2022, QUAL LIFE RES, V31, P1761, DOI 10.1007/s11136-021-02991-2
   Sforzini L, 2019, PSYCHOPHARMACOLOGY, V236, P2997, DOI 10.1007/s00213-019-05200-8
   Singh NP, 2005, RENAL FAILURE, V27, P123, DOI 10.1081/JDI-200042811
   Song P, 2017, CELL MOL LIFE SCI, V74, P2899, DOI 10.1007/s00018-017-2504-2
   Szelest M, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22031104
   Takeshita J, 2017, J AM ACAD DERMATOL, V76, P377, DOI 10.1016/j.jaad.2016.07.064
   Wan MT, 2018, J AM ACAD DERMATOL, V78, P315, DOI 10.1016/j.jaad.2017.10.050
   Wang S, 2020, BMC CANCER, V20, DOI 10.1186/s12885-020-06956-5
   Wang XX, 2021, BIOMED PHARMACOTHER, V137, DOI 10.1016/j.biopha.2020.111065
   Weber B, 2021, CURR ATHEROSCLER REP, V23, DOI 10.1007/s11883-021-00963-y
   Wee HN, 2021, AM J NEPHROL, V52, P771, DOI 10.1159/000519811
   Wild J, 2020, J CLIN MED, V9, DOI 10.3390/jcm9093004
   Wu JJ, 2022, J EUR ACAD DERMATOL, V36, P797, DOI 10.1111/jdv.18044
   Zádor F, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22115903
NR 50
TC 5
Z9 5
U1 2
U2 15
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 2193-8210
EI 2190-9172
J9 DERMATOLOGY THER
JI Dermatol. Ther.
PD AUG
PY 2023
VL 13
IS 8
BP 1617
EP 1627
DI 10.1007/s13555-023-00958-4
EA JUN 2023
PG 11
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA M5NU5
UT WOS:001007893900001
PM 37326759
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Muraishi, M
   Shibayama, K
   Noguchi, M
   Watanabe, H
   Obunai, K
AF Muraishi, Makio
   Shibayama, Kentaro
   Noguchi, Masahiko
   Watanabe, Hiroyuki
   Obunai, Kotaro
TI Significance of intravascular ultrasound and exercise stress
   echocardiography in diagnosis of exercise-induced vasospastic angina at
   the site of moderate stenosis
SO JOURNAL OF MEDICAL ULTRASONICS
LA English
DT Article
DE Vasospastic angina; Intracoronary imaging; Stress echocardiography
ID CORONARY ARTERIAL SPASM; VARIANT ANGINA
AB Recently, exercise-induced spastic coronary artery occlusion at the site of moderate stenosis, which Prinzmetal's angina or cardiac syndrome X does not cover, was reported. Multi-modality imaging is important for the diagnosis of coronary artery disease with a complex ischemic mechanism. However, the previous report did not include findings from intracoronary imaging at the site of moderate coronary stenosis. We report a case of exercise-induced vasospastic angina at the site of moderate stenosis, where multi-modality imaging, including exercise stress echocardiography and intravascular ultrasound, was utilized to make a definitive diagnosis and investigate underlying causes.
C1 [Muraishi, Makio; Shibayama, Kentaro; Noguchi, Masahiko; Watanabe, Hiroyuki; Obunai, Kotaro] Tokyo Bay Urayasu Ichikawa Med Ctr, Dept Cardiol, 3-4-32 Todaijima, Chiba 2790001, Japan.
RP Shibayama, K (corresponding author), Tokyo Bay Urayasu Ichikawa Med Ctr, Dept Cardiol, 3-4-32 Todaijima, Chiba 2790001, Japan.
EM shibao_k@hotmail.com
RI Noguchi, Masahiko/JZT-2712-2024
OI Noguchi, Masahiko/0000-0003-4501-3449
CR ROBERTSON RM, 1982, CIRCULATION, V65, P281, DOI 10.1161/01.CIR.65.2.281
   SPECCHIA G, 1979, CIRCULATION, V59, P948, DOI 10.1161/01.CIR.59.5.948
   YASUE H, 1979, CIRCULATION, V59, P938, DOI 10.1161/01.CIR.59.5.938
   Yilmaz A, 2010, CIRCULATION, V122, pE570, DOI 10.1161/CIRCULATIONAHA.110.984823
NR 4
TC 0
Z9 0
U1 1
U2 2
PU SPRINGER JAPAN KK
PI TOKYO
PA CHIYODA FIRST BLDG EAST, 3-8-1 NISHI-KANDA, CHIYODA-KU, TOKYO, 101-0065,
   JAPAN
SN 1346-4523
EI 1613-2254
J9 J MED ULTRASON
JI J. Med. Ultrason.
PD APR
PY 2018
VL 45
IS 2
BP 315
EP 317
DI 10.1007/s10396-017-0815-4
PG 3
WC Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Radiology, Nuclear Medicine & Medical Imaging
GA GA0DN
UT WOS:000427983200015
PM 28819899
DA 2025-06-11
ER

PT J
AU Yamagishi, S
   Nakamura, K
   Inoue, H
AF Yamagishi, S
   Nakamura, K
   Inoue, H
TI Acarbose is a promising therapeutic strategy for the treatment of
   patients with nonalcoholic steatohepatitis (NASH)
SO MEDICAL HYPOTHESES
LA English
DT Article
ID FATTY LIVER-DISEASE; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   PREVENTION; PREDICTORS; FIBROSIS; RISK
AB The metabolic syndrome is strongly associated with insulin resistance and has been recognized as a cluster of risk factors for cardiovascular diseases such as visceral obesity, hypertension, and diabetes. There is a growing body of evidence to show that nonalcoholic steatohepatitis (NASH) is the hepatic manifestation of insulin resistant patients with the metabolic syndrome. Indeed, insulin resistance increases adipocyte lipolysis and subsequently elevates circulating free fatty acids, thus stimulating the accumulation of fatty acids in the liver (hepatic steatosis). Fatty acids elicit reactive oxygen species generation, thereby promoting disease progression to NASH by both lipid peroxidation and inflammatory cytokine production. Postprandial hyperglycemia, one of the characteristic features of insulin resistance, also induces oxidative stress generation, being involved in dysfunction of pancreatic beta cells and vascular wall cells in the metabolic syndrome. Recently, STOP-NIDDM trial revealed that acarbose (Glucobay((R))), an alpha-glucosidase inhibitor, improved postprandial hyperglycemia and subsequently reduced the risk of development of type 2 diabetes and newly diagnosed hypertension in patients with impaired glucose tolerance. In this study, acarbose treatment was also found to reduce body mass index and waist circumference in these patients. Furthermore, a meta-analysis of seven tong-term studies has also shown that intervention with acarbose improved triglyceride Levels, body weight and systolic blood pressure and subsequently prevented myocardial infarction in type 2 diabetic patients. Since acarbose improves postprandial hyperglycemia by delaying the release of glucose from complex carbohydrates in the absence of an increase in insulin secretion, the beneficial aspects of acarbose could be ascribed to improvement of insulin sensitivity in these patients. Given the pathological link between NASH and insulin resistance, we would like to hypothesize here that acarbose may become a promising therapeutic strategy for the treatment of patients with NASH. Does acarbose treatment improve steatohepatitis histologically? Is the extent of histological improvement by acarbose parallel to that of insulin sensitivity in these patients? Large clinical trials will provide us with more definite information whether acarbose treatment can improve insulin sensitivity and resultantly reduce the risk of progression of liver diseases in patients with NASH. (c) 2005 Elsevier Ltd. All rights reserved.
C1 Kurume Univ, Sch Med, Dept Med, Kurume, Fukuoka 8300011, Japan.
   Kurume Univ, Sch Med, Radioisotope Inst Basic & Clin Med, Kurume, Fukuoka 8300011, Japan.
C3 Kurume University; Kurume University
RP Kurume Univ, Sch Med, Dept Med, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
EM shoichi@med.kurume-u.ac.jp
CR Angulo P, 1999, HEPATOLOGY, V30, P1356, DOI 10.1002/hep.510300604
   Angulo P., 2000, NEW ENGL J MED, V346, P1221
   Boden G, 1997, DIABETES, V46, P3, DOI 10.2337/diabetes.46.1.3
   Breuer HWM, 2003, INT J CLIN PHARM TH, V41, P421
   Brunt EM, 2004, SEMIN LIVER DIS, V24, P3
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Chiasson JL, 2002, LANCET, V359, P2072, DOI 10.1016/S0140-6736(02)08905-5
   Chiasson JL, 2003, JAMA-J AM MED ASSOC, V290, P486, DOI 10.1001/jama.290.4.486
   Choudhury Jayanta, 2004, Clin Liver Dis, V8, P575, DOI 10.1016/j.cld.2004.04.006
   Dixon JB, 2001, GASTROENTEROLOGY, V121, P91, DOI 10.1053/gast.2001.25540
   Grant Lafaine M, 2004, Ann Hepatol, V3, P93
   Hanefeld M, 2004, EUR HEART J, V25, P10, DOI 10.1016/S0195-668X(03)00468-8
   Harrison SA, 2002, AM J GASTROENTEROL, V97, P2714
   Heine RJ, 2002, DIABETOLOGIA, V45, P461, DOI 10.1007/s00125-001-0726-0
   Kumar KS, 2000, MAYO CLIN PROC, V75, P733
   Matteoni CA, 1999, GASTROENTEROLOGY, V116, P1413, DOI 10.1016/S0016-5085(99)70506-8
   PROPST A, 1995, GASTROENTEROLOGY, V108, P1607, DOI 10.1016/0016-5085(95)90724-6
   Rösen P, 2001, DIABETES-METAB RES, V17, P189, DOI 10.1002/dmrr.196
   Sanyal Arun J, 2002, Gastroenterology, V123, P1705, DOI 10.1053/gast.2002.36572
   Scheen A J, 2004, Minerva Endocrinol, V29, P31
   Tolman KG, 2004, ANN INTERN MED, V141, P946, DOI 10.7326/0003-4819-141-12-200412210-00011
   Youssef Wael, 2002, Semin Gastrointest Dis, V13, P17
NR 22
TC 12
Z9 13
U1 0
U2 10
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PY 2005
VL 65
IS 2
BP 377
EP 379
DI 10.1016/j.mehy.2005.01.032
PG 3
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 935YI
UT WOS:000229818900029
PM 15922116
DA 2025-06-11
ER

PT J
AU Rabelo, F
   Stefano, JT
   Cavaleiro, AM
   Lima, RVC
   Mazo, DD
   Carrilho, FJ
   Correa-Giannella, ML
   Oliveira, CP
AF Rabelo, Fabiola
   Stefano, Jose Tadeu
   Cavaleiro, Ana Mercedes
   Costa Lima, Rodrigo Vieira
   de Campos Mazo, DanielFerraz
   Carrilho, Flair Jose
   Correa-Giannella, Maria Lucia
   Oliveira, Claudia P.
TI Association between the CYBA and NOX4 genes of NADPH oxidase and its
   relationship with metabolic syndrome in non-alcoholic fatty liver
   disease in Brazilian population
SO HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
LA English
DT Article
DE Non-alcoholic fatty liver disease; Nonalcoholic steatohepatitis; Genetic
   polymorphism; Metabolic syndrome
ID GENOME-WIDE ASSOCIATION; OXIDATIVE STRESS; POLYMORPHISMS;
   STEATOHEPATITIS; VARIANT; NEPHROPATHY; DIAGNOSIS; FIBROSIS
AB Background: Oxidative stress has been implicated in the progression of severe forms of non-alcoholic fatty liver disease (NAFLD). NADPH oxidase produces reactive oxygen species. In the present study, we investigated for the first time two single nucleotide polymorphisms (SNPs) in the regulatory region of genes encoding NADPH oxidase 4 (NOX4) and p22phox (CYBA) in NAFLD.
   Methods: A total of 207 biopsy-proven NAFLD patients [simple steatosis (n =27); nonalcoholic steatohepatitis (NASH) (n =180)] were evaluated. Genomic DNA was extracted from peripheral blood cells, and polymorphisms in CYBA (unregistered) and NOX4 (rs3017887) were determined by direct sequencing of PCR.
   Results: Associations of CYBA-675 T/A with high-density lipoprotein (HDL) (TT vs TA vs AA; P <0.01) and triglycerides (TGL) (TT vs XA; P < 0.01) were observed only in NASH patients. For polymorphisms in the NOX4 gene, NOX4 (rs3017887) CA + AA genotypes was significant associated with alanine aminotransferase (ALT) (CA + AA vs CC; P=0.02). However, there was no association of SNPs in the CYBA and NOX4 genes encoding the NADPH oxidase system proteins and the presence of NASH. Regarding the clinical results, it was observed that the most advanced degrees of fibrosis occurred in patients diagnosed with type 2 diabetes mellitus (66.9% vs 37.5%, P < 0.01) and those who were more obese (32.2 vs 29.0 kg/m(2), P < 0.01). In addition, serum glucose and insulin levels increased significantly in the presence of NASH.
   Conclusions: There were associations between the presence of the allele A in the NOX4 SNP and a higher concentration of ALT in the NAFLD population; between the presence of the AA genotype in the polymorphism of the CYBA-675 T/A CYBA gene and a higher level of TGL and lower HDL in NASH patients. The presence of metabolic syndrome was associated with advanced degrees of fibrosis in NAFLD patients. (C) 2018 First Affiliated Hospital, Zhejiang University School of Medicine in China. Published by Elsevier B.V. All rights reserved.
C1 [Rabelo, Fabiola; Costa Lima, Rodrigo Vieira; Carrilho, Flair Jose; Oliveira, Claudia P.] Univ Sao Paulo, Fac Med FMUSP, Dept Gastroenterol, Sao Paulo, SP, Brazil.
   [Rabelo, Fabiola; Stefano, Jose Tadeu; Costa Lima, Rodrigo Vieira; de Campos Mazo, DanielFerraz; Carrilho, Flair Jose; Oliveira, Claudia P.] Univ Sao Paulo, Fac Med, LIM07, Hosp Clin HCFMUSP,Dept Gastroenterol, Sao Paulo, SP, Brazil.
   [Cavaleiro, Ana Mercedes; Correa-Giannella, Maria Lucia] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP LIM07, Lab Carboidratos & Radioimunensaio,LIM18, Sao Paulo, Brazil.
   [Correa-Giannella, Maria Lucia] Univ Nove Julho UNINOVE, Programa Posgrad Med, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade de
   Sao Paulo; Universidade Nove de Julho
RP Oliveira, CP (corresponding author), Univ Sao Paulo, Fac Med FMUSP, Dept Gastroenterol, Sao Paulo, SP, Brazil.; Oliveira, CP (corresponding author), Univ Sao Paulo, Fac Med, LIM07, Hosp Clin HCFMUSP,Dept Gastroenterol, Sao Paulo, SP, Brazil.
EM cpm@usp.br
RI Carrilho, Flair/I-3046-2012; Correa-Giannella, Maria Lúcia/N-3834-2019;
   STEFANO, JOSE TADEU/AGR-5605-2022; Oliveira, Claudia/D-1216-2014; Mazo,
   Daniel/D-5631-2015
OI Carrilho, Flair Jose/0000-0002-7682-3105; Mazo,
   Daniel/0000-0002-2164-2630; P Oliveira, Claudia/0000-0002-2848-417X;
   Correa-Giannella, Maria Lucia/0000-0003-3655-4446
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
   [Convenio PROAP 190/2014]
FX This study was supported by the grant from Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES) Grant no. Convenio
   PROAP 190/2014.
CR [Anonymous], 2015, DIABETES CARE, V38, pS8, DOI 10.2337/dc15-S005
   Bedard K, 2007, PHYSIOL REV, V87, P245, DOI 10.1152/physrev.00044.2005
   Bedard K, 2009, HUM MUTAT, V30, P1123, DOI 10.1002/humu.21029
   Bettaieb A, 2015, GASTROENTEROLOGY, V149, P468, DOI 10.1053/j.gastro.2015.04.009
   Brunt EM, 2009, CLIN LIVER DIS, V13, P533, DOI 10.1016/j.cld.2009.07.008
   Burt AD, 2015, SEMIN LIVER DIS, V35, P207, DOI 10.1055/s-0035-1562942
   Chalasani N, 2012, GASTROENTEROLOGY, V142, P1592, DOI 10.1053/j.gastro.2012.04.001
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cohen DE, 2013, SEMIN LIVER DIS, V33, P380, DOI 10.1055/s-0033-1358519
   De Minicis S, 2010, HEPATOLOGY, V52, P1420, DOI 10.1002/hep.23804
   de Siqueira ERF, 2015, EUR J MED RES, V20, DOI 10.1186/s40001-015-0136-2
   Hirschhorn JN, 2011, ANNU REV MED, V62, P11, DOI 10.1146/annurev.med.091708.162036
   Hodgkinson AD, 2003, DIABETES CARE, V26, P3111, DOI 10.2337/diacare.26.11.3111
   Jiang JX, 2012, FREE RADICAL BIO MED, V53, P289, DOI 10.1016/j.freeradbiomed.2012.05.007
   José GS, 2008, CLIN SCI, V114, P173, DOI 10.1042/CS20070130
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Lan T, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0129743
   Liang S, 2016, FRONT PHYSIOL, V7, DOI 10.3389/fphys.2016.00017
   Lim SC, 2009, DIABETOLOGIA, V52, P1343, DOI 10.1007/s00125-009-1368-x
   Makkonen J, 2009, J HEPATOL, V50, P1035, DOI 10.1016/j.jhep.2008.12.025
   Moreno MU, 2007, J HYPERTENS, V25, P1620, DOI 10.1097/HJH.0b013e3281ac211d
   Oliveira CP, 2015, CLIN RES HEPATOL GAS, V39, pS35, DOI 10.1016/j.clinre.2015.05.014
   Parker HM, 2012, J HEPATOL, V56, P944, DOI 10.1016/j.jhep.2011.08.018
   Patente TA, 2015, GENE, V568, P50, DOI 10.1016/j.gene.2015.05.017
   Quigley EM, 2015, SEMIN LIVER DIS, V35, P262, DOI 10.1055/s-0035-1562946
   Sancho P, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0045285
   Song HR, 2008, AM J CLIN NUTR, V88, P16, DOI 10.1093/ajcn/88.1.16
   Sookoian S, 2015, WORLD J GASTROENTERO, V21, P711, DOI 10.3748/wjg.v21.i3.711
   Tariq Z, 2014, LIVER INT, V34, pE180, DOI 10.1111/liv.12523
   Wang C, 2017, BIOMED REP, V7, P95, DOI 10.3892/br.2017.926
   Wu KT, 2016, J CLIN LIPIDOL, V10, P420, DOI 10.1016/j.jacl.2015.12.026
   Zegers D, 2016, CLIN RES HEPATOL GAS, V40, P715, DOI 10.1016/j.clinre.2016.05.004
NR 32
TC 16
Z9 17
U1 0
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1499-3872
EI 2352-9377
J9 HEPATOB PANCREAT DIS
JI Hepatob. Pancreatic. Dis. Int.
PD AUG
PY 2018
VL 17
IS 4
BP 330
EP 335
DI 10.1016/j.hbpd.2018.06.005
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA GS0OC
UT WOS:000443199800008
PM 30087027
DA 2025-06-11
ER

PT J
AU Boutayeb, A
   Boutayeb, S
   Boutayeb, W
AF Boutayeb, Abdesslam
   Boutayeb, Saber
   Boutayeb, Wiam
TI Multi-morbidity of non communicable diseases and equity in WHO Eastern
   Mediterranean countries
SO INTERNATIONAL JOURNAL FOR EQUITY IN HEALTH
LA English
DT Article
ID NONCOMMUNICABLE DISEASES; DEPRESSIVE-DISORDERS; CO-MORBIDITIES;
   PREVALENCE; ANXIETY; COMORBIDITY; HEALTH; BURDEN; ASSOCIATION; PATTERNS
AB Introduction: Non communicable diseases are the biggest cause of death worldwide. Beside mortality, these diseases also cause high rates of morbidity and disability. Their high prevalence is generally associated to multi-morbidity. Because they need costly prolonged treatment and care, non communicable diseases have social and economical consequences that affect individuals, households and the whole society. They raise the equity problem between and within countries.
   Methods and limitations: This annotated bibliography is a systematic review on multimorbidy of non communicable diseases and health equity in WHO Eastern Mediterranean countries. Medline/PubMed, EMBASE and other sources were used to get peer reviewed papers dealing with the review theme. The words/strings used for search and inclusion criteria were: multimorbidity, comorbidity, equity, non communicable diseases, chronic diseases, WHO Eastern Mediterranean and Arab countries.
   Bibliography with annotations: According to the inclusion criteria, 26 papers were included in the present review. Generally, lack or paucity of publications was encountered in themes like headache, cancer and respiratory diseases. Of the 26 contributions selected, twelve dealt with comorbidity of depression and mental disorders with other chronic diseases. Another set of 11 publications was devoted to multimorbidity of diabetes, cardiovascular diseases (CVDs), hypertension, metabolic syndrome and obesity. Considering association of multimorbidity and social determinants, this review shows that female gender, low income, low level of education, old age and unemployed/retired are the most exposed to multimorbidity. It should also be stressed that, geographically, no contribution was issued from North African countries.
   Non communicable diseases are one of the biggest challenges facing health decision makers in WHO Eastern Mediterranean countries where the multidimensional transition is boosting increases in multimorbidity of depression and mental diseases, cardiovascular diseases, diabetes, cancer and respiratory diseases among the whole population but with the highest burden among the least disadvantaged individuals or subpopulations. Health ministries in WHO Eastern Mediterranean countries should pay a particular attention to the association between equity and multimorbidity and opt for cost effective strategies based on early diagnosis and sensitisation for healthy diet, physical activity, no smoking and no alcohol.
C1 [Boutayeb, Abdesslam; Boutayeb, Wiam] Univ Mohamed Ier, LaMSD, Dept Math, Oujda, Morocco.
   [Boutayeb, Abdesslam; Boutayeb, Wiam] Univ Mohamed Ier, Fac Sci, URAC04, Oujda, Morocco.
   [Boutayeb, Saber] Natl Inst Oncol, Dept Med Oncol, Rabat, Morocco.
C3 Mohammed First University of Oujda; Mohammed First University of Oujda;
   Mohammed V University in Rabat; Ibn sina University Hospital Center of
   Rabat
RP Boutayeb, A (corresponding author), Univ Mohamed Ier, LaMSD, Dept Math, Oujda, Morocco.
EM x.boutayeb@menara.ma
OI boutayeb, saber/0000-0003-1642-9330; Boutayeb,
   Abdesslam/0000-0003-0579-4383
CR Abdul-Rahim HF, 2001, INT J OBESITY, V25, P1736, DOI 10.1038/sj.ijo.0801799
   Al-Amer RM, 2011, J DIABETES COMPLICAT, V25, P247, DOI 10.1016/j.jdiacomp.2011.03.001
   Almawi W, 2008, J ENDOCRINOL INVEST, V31, P1020, DOI 10.1007/BF03345642
   Alwakeel JS, 2009, SAUDI J KIDNEY DIS T, V20, P402
   [Anonymous], 2022, NONCOMMUNICABLE DIS
   [Anonymous], TANAFFOS
   Aziz Zeba, 2002, Gan To Kagaku Ryoho, V29 Suppl 1, P4
   Benamer HTS, 2010, J HEADACHE PAIN, V11, P1, DOI 10.1007/s10194-009-0173-8
   Bener A, 2012, SOC PSYCH PSYCH EPID, V47, P439, DOI 10.1007/s00127-011-0349-9
   Bernieh B, 2004, TRANSPLANT P, V36, P1780, DOI 10.1016/j.transproceed.2004.07.015
   Bokhari S. A. H., 2009, Eastern Mediterranean Health Journal, V15, P1011
   Boutayeb A, 2006, T ROY SOC TROP MED H, V100, P191, DOI 10.1016/j.trstmh.2005.07.021
   Boutayeb A., 2012, OPEN J EPIDEMIOLOGY, V2, P55
   Boutayeb Abdesslam, 2005, Int J Equity Health, V4, P2, DOI 10.1186/1475-9276-4-2
   Center for Studies on Aging (CSA), 2010, CHRON DIS AG E MED R
   Commission on Social Determinants of health, 2008, CLOS GAP GEN HLTH EQ
   Delavar MA, 2009, ASIA PAC J CLIN NUTR, V18, P285
   Hollisaaz MT, 2007, TRANSPL P, V39, P1048, DOI 10.1016/j.transproceed.2007.03.061
   Hosseinpoor AR, 2012, BMC PUBLIC HEALTH, V12, DOI 10.1186/1471-2458-12-474
   Husseini A, 2009, LANCET, V373, P1041, DOI 10.1016/S0140-6736(09)60109-4
   International Diabetes Federation, 2011, IDF DIABETES ATLAS
   Khader Yousef, 2008, Metabolic Syndrome and Related Disorders, V6, P113, DOI 10.1089/met.2007.0030
   Khan Muhammad S, 2006, BMC Cardiovasc Disord, V6, P18, DOI 10.1186/1471-2261-6-18
   Khuwaja AK, 2010, DIABETOL METAB SYNDR, V2, DOI 10.1186/1758-5996-2-72
   Kilzieh N, 2008, INT J PSYCHIAT MED, V38, P169, DOI 10.2190/PM.38.2.d
   Maziak W, 2007, ANN EPIDEMIOL, V17, P713, DOI 10.1016/j.annepidem.2007.03.016
   Moussavi S, 2007, LANCET, V370, P851, DOI 10.1016/S0140-6736(07)61415-9
   Ohaeri JU, 2012, MED SCI MONITOR, V18, pCR160, DOI 10.12659/MSM.882521
   Pennell WT, 2011, TECHNICAL CHALLENGES OF MULTIPOLLUTANT AIR QUALITY MANAGEMENT, P1, DOI 10.1007/978-94-007-0304-9_1
   Riachy M, 2008, REV MAL RESPIR, V25, P275, DOI 10.1016/S0761-8425(08)71546-8
   Rithie CS, 2011, J ONCOLOGY PRACTICE, V7, P371
   Schwab K., 2010, GLOBAL RISKS 2010 A
   Shah NM, 2010, MED PRIN PRACT, V19, P105, DOI 10.1159/000273069
   Shera A. S., 2004, JPMA Journal of the Pakistan Medical Association, V54, P54
   Shiri R, 2006, AM J ADDICTION, V15, P468, DOI 10.1080/10550490601000421
   The WHO, 2011, Global Atlas on Cardiovascular Disease Prevention and Control, P2
   UNDP, HUM DEV IND IN ADJ H
   Waheed Abdul, 2006, JPMA Journal of the Pakistan Medical Association, V56, P243
   WHO, 2010, WORLD MALARIA REPORT 2010, P1
   World Health Organization, 2011, CLOS GAP POL PRACT S
   Yekta Z., 2010, Eastern Mediterranean Health Journal, V16, P286
   Youssef R. M., 2005, Eastern Mediterranean Health Journal, V11, P334
   Zindah Meyasser, 2008, Prev Chronic Dis, V5, pA17
NR 43
TC 88
Z9 100
U1 0
U2 24
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1475-9276
J9 INT J EQUITY HEALTH
JI Int. J. Equity Health
PD AUG 20
PY 2013
VL 12
AR 60
DI 10.1186/1475-9276-12-60
PG 13
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 222NG
UT WOS:000324737300001
PM 23961989
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Slagter, SN
   van Vliet-Ostaptchouk, JV
   van Beek, AP
   Keers, JC
   Lutgers, HL
   van der Klauw, MM
   Wolffenbuttel, BHR
AF Slagter, Sandra N.
   van Vliet-Ostaptchouk, Jana V.
   van Beek, Andre P.
   Keers, Joost C.
   Lutgers, Helen L.
   van der Klauw, Melanie M.
   Wolffenbuttel, Bruce H. R.
TI Health-Related Quality of Life in Relation to Obesity Grade, Type 2
   Diabetes, Metabolic Syndrome and Inflammation
SO PLOS ONE
LA English
DT Article
ID C-REACTIVE PROTEIN; BODY-MASS INDEX; CHRONIC KIDNEY-DISEASE;
   FUNCTIONAL-CAPACITY; INDIVIDUALS; SF-36; MEN; ASSOCIATION; OVERWEIGHT;
   WEIGHT
AB Background
   Health-related quality of life (HR-QoL) may be compromised in obese individuals, depending on the presence of other complications. The aim of this study is to assess the effect of obesity-related conditions on HR-QoL. These conditions are i) grade of obesity with and without type 2 diabetes (T2D), ii) metabolic syndrome (MetS), and iii) level of inflammation.
   Methods
   From the Dutch LifeLines Cohort Study we included 13,686 obese individuals, aged 18-80 years. HR-QoL was measured with the RAND 36-Item Health Survey which encompasses eight health domains. We calculated the percentage of obese individuals with poor HR-QoL, i.e. those scoring below the domain and sex specific cut-off value derived from the normal weight population. Logistic regression analysis was used to calculate the probability of having poor domain scores according to the conditions under study.
   Results
   Higher grades of obesity and the additional presence of T2D were associated with lower HR-QoL, particularly in the domains physical functioning (men: odds ratios (ORs) 1.48-11.34, P<0.005, and women: ORs 1.66-5.05, P<0.001) and general health (men: ORs 1.44-3.07, P<0.005, and women: ORs 1.36-3.73, P<0.001). A higher percentage of obese individuals with MetS had a poor HR-QoL than those without MetS. Furthermore, we observed a linear trend between inflammation and the percentage of obese individuals with poor scores on the HR-QoL domains. Individuals with MetS were more likely to have poor scores in the domains general health, vitality, social functioning and role limitations due to emotional problems. Obese women with increased inflammation levels were more likely to have poor scores on all domains except role limitations due to emotional problems and mental health.
   Conclusions
   The impact of obesity on an individual's quality of life is enhanced by grade of obesity, T2D, MetS and inflammation and are mainly related to reduced physical health. The mental wellbeing is less often impaired.
C1 [Slagter, Sandra N.; van Vliet-Ostaptchouk, Jana V.; van Beek, Andre P.; Keers, Joost C.; Lutgers, Helen L.; van der Klauw, Melanie M.; Wolffenbuttel, Bruce H. R.] Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, Groningen, Netherlands.
   [Keers, Joost C.] Martini Hosp, Van Swieten Res Inst, Groningen, Netherlands.
C3 University of Groningen; Martini Hospital
RP Wolffenbuttel, BHR (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, Groningen, Netherlands.
EM bwo@umcg.nl
RI Lutgers, Helen/MFK-2548-2025; van der Klauw, Melanie/A-2138-2014; van
   Beek, Andre/O-3753-2014
OI van Vliet-Ostaptchouk, Jana/0000-0002-7943-3153; van der Klauw,
   Melanie/0000-0001-7178-009X; van Beek, Andre/0000-0002-0335-8177;
   Wolffenbuttel, Bruce H.R./0000-0001-9262-6921
FU Netherlands Organization of Scientific Research (NWO)
   [175.010.2007.006]; Economic Structure Enhancing Fund (FES) of the Dutch
   government; Ministry of Economic Affairs; Ministry of Education, Culture
   and Science; Ministry for Health, Welfare and Sports; Northern
   Netherlands Collaboration of Provinces (SNN); Province of Groningen;
   University Medical Center Groningen; University of Groningen; Dutch
   Kidney Foundation; Dutch Diabetes Research Foundation; National
   Consortium for Healthy Ageing; European Union's Seventh Framework
   programme (FP7) through the BioSHaRE-EU (Biobank Standardisation and
   Harmonisation for Research Excellence in the European Union) [261433]
FX The LifeLines Cohort Study was supported by the Netherlands Organization
   of Scientific Research (NWO) [grant 175.010.2007.006]; the Economic
   Structure Enhancing Fund (FES) of the Dutch government; the Ministry of
   Economic Affairs; the Ministry of Education, Culture and Science; the
   Ministry for Health, Welfare and Sports; the Northern Netherlands
   Collaboration of Provinces (SNN); the Province of Groningen; University
   Medical Center Groningen; the University of Groningen; the Dutch Kidney
   Foundation; and the Dutch Diabetes Research Foundation. This work was
   supported by the National Consortium for Healthy Ageing, and the
   European Union's Seventh Framework programme (FP7/2007-2013) through the
   BioSHaRE-EU (Biobank Standardisation and Harmonisation for Research
   Excellence in the European Union) project, grant agreement 261433.
CR Amiri P, 2010, J WOMENS HEALTH, V19, P1201, DOI 10.1089/jwh.2009.1710
   Baiano M, 2014, BMC PSYCHIATRY, V14, DOI 10.1186/1471-244X-14-165
   Bentley TGK, 2011, QUAL LIFE RES, V20, P665, DOI 10.1007/s11136-011-9878-7
   Cai ZJ, 1999, WHO TECH REP SER, V887, P1
   Cameron AJ, 2012, INT J OBESITY, V36, P295, DOI 10.1038/ijo.2011.103
   Choo J, 2014, BMJ OPEN, V4, DOI 10.1136/bmjopen-2013-003954
   Cummings DM, 2003, ANN PHARMACOTHER, V37, P1593, DOI 10.1345/aph.1D029
   de Zwaan M, 2009, PSYCHOSOMATICS, V50, P474, DOI 10.1176/appi.psy.50.5.474
   Doll HA, 2000, OBES RES, V8, P160, DOI 10.1038/oby.2000.17
   Farag YMK, 2011, CLIN NEPHROL, V75, P524, DOI 10.5414/CNP75524
   Farivar SS, 2007, HEALTH QUAL LIFE OUT, V5, DOI 10.1186/1477-7525-5-54
   Flegal KM, 2013, JAMA-J AM MED ASSOC, V309, P71, DOI 10.1001/jama.2012.113905
   Fontaine K R, 2001, Obes Rev, V2, P173, DOI 10.1046/j.1467-789x.2001.00032.x
   Ford ES, 1999, DIABETES CARE, V22, P1971, DOI 10.2337/diacare.22.12.1971
   Formiguera X, 2004, BEST PRACT RES CL GA, V18, P1125, DOI [10.1016/S1521-6918(04)00091-5, 10.1016/j.bpg.2004.06.030]
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Jagielski AC, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0092859
   Jia HM, 2005, J PUBLIC HEALTH-UK, V27, P156, DOI 10.1093/pubmed/fdi025
   Kalender B, 2007, INT J CLIN PRACT, V61, P569, DOI 10.1111/j.1742-1241.2006.01251.x
   Kolotkin RL, 2002, OBES RES, V10, P748, DOI 10.1038/oby.2002.102
   Korhonen PE, 2014, QUAL LIFE RES, V23, P67, DOI 10.1007/s11136-013-0433-6
   Lakoski SG, 2006, AM HEART J, V152, P593, DOI 10.1016/j.ahj.2006.02.015
   Levinger I, 2007, DIABETES CARE, V30, P2205, DOI 10.2337/dc07-0841
   Levinger I, 2009, INT J CARDIOL, V133, P281, DOI 10.1016/j.ijcard.2007.11.046
   Mommersteeg PMC, 2012, BRAIN BEHAV IMMUN, V26, P301, DOI 10.1016/j.bbi.2011.09.010
   Motie M, 2014, EXP THER MED, V8, P181, DOI 10.3892/etm.2014.1673
   Renzaho A, 2010, QUAL LIFE RES, V19, P515, DOI 10.1007/s11136-010-9610-z
   Ridker PM, 2003, CIRCULATION, V108, pE81, DOI 10.1161/01.CIR.0000093381.57779.67
   Rieger E, 2005, INT J EAT DISORDER, V37, P234, DOI 10.1002/eat.20101
   Serrano-Aguilar P, 2009, QUAL LIFE RES, V18, P171, DOI 10.1007/s11136-008-9427-1
   Soltoft F, 2009, QUAL LIFE RES, V18, P1293, DOI 10.1007/s11136-009-9541-8
   Stolk RP, 2008, EUR J EPIDEMIOL, V23, P67, DOI 10.1007/s10654-007-9204-4
   Taft C, 2001, QUAL LIFE RES, V10, P395, DOI 10.1023/A:1012552211996
   Tapp RJ, 2006, DIABETES RES CLIN PR, V74, P154, DOI 10.1016/j.diabres.2006.03.012
   Tsai AG, 2008, OBESITY, V16, P59, DOI 10.1038/oby.2007.8
   van der Zee KI, 1996, INT J BEHAV MED, V3, P104, DOI 10.1207/s15327558ijbm0302_2
   van Vliet-Ostaptchouk JV, 2014, BMC ENDOCR DISORD, V14, DOI 10.1186/1472-6823-14-9
   Vetter ML, 2011, INT J OBESITY, V35, P1087, DOI 10.1038/ijo.2010.230
   Visser M, 1999, JAMA-J AM MED ASSOC, V282, P2131, DOI 10.1001/jama.282.22.2131
   Wong YYE, 2012, MATURITAS, V73, P158, DOI 10.1016/j.maturitas.2012.06.007
NR 40
TC 64
Z9 70
U1 0
U2 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 16
PY 2015
VL 10
IS 10
AR e0140599
DI 10.1371/journal.pone.0140599
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA CU0DF
UT WOS:000363185500071
PM 26474291
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Kaur, D
   Bucholc, M
   Finn, DP
   Todd, S
   Wong-Lin, K
   McClean, PL
AF Kaur, Daman
   Bucholc, Magda
   Finn, David P.
   Todd, Stephen
   Wong-Lin, Kongfatt
   McClean, Paula L.
TI Multi-time-point data preparation robustly reveals MCI and dementia risk
   factors
SO ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
LA English
DT Article
DE baseline; cardiometabolic risk factors; dementia progression;
   longitudinal data; mild cognitive impairment (MCI); multi-time-point
   data preparation; multivariate logistic regression; National Alzheimer's
   Coordinating Center data
ID MILD COGNITIVE IMPAIRMENT; DEPRESSIVE SYMPTOMS; INCIDENT DEMENTIA;
   ALZHEIMER-DISEASE; MEASUREMENT ERROR; HYPERTENSION; DECLINE; MIDLIFE;
   OLD; EPIDEMIOLOGY
AB Introduction: Conflicting results on dementia risk factors have been reported across studies. We hypothesize that variation in data preparation methods may partially contribute to this issue.
   Methods: We propose a comprehensive data preparation approach comparing individuals with stable diagnosis over time to those who progress to mild cognitive impairment (MCI)/dementia. This was compared to the often-used "baseline" analysis. Multivariate logistic regression was used to evaluate both methods.
   Results: The results obtained from sensitivity analyses were consistent with those from our multi-time-point data preparation approach, exhibiting its robustness. Compared to analysis using only baseline data, the number of significant risk factors identified in progression analyses was substantially lower. Additionally, we found that moderate depression increased healthy-to-MCI/dementia risk, while hypertension reduced MCI-to-dementia risk.
   Discussion: Overall, multi-time-point-based data preparation approaches may pave the way for a better understanding of dementia risk factors, and address some of the reproducibility issues in the field.
C1 [Kaur, Daman; McClean, Paula L.] Ulster Univ, Northern Ireland Ctr Stratified Med, Biomed Sci Res Inst, Clin Translat Res & Innovat Ctr C TRIC, Altnagelvin Hosp Site, Derry Londonderry, North Ireland.
   [Bucholc, Magda; Wong-Lin, Kongfatt] Ulster Univ, Intelligent Syst Res Ctr, Sch Comp Engn & Intelligent Syst, Derry Londonderry, North Ireland.
   [Finn, David P.] Natl Univ Ireland Galway, Pharmacol & Therapeut, Sch Med, Galway Neurosci Ctr, Univ Rd, Galway, Ireland.
   [Todd, Stephen] Western Hlth & Social Care Trust, Altnagelvin Area Hosp, Derry Londonderry, Ireland.
C3 Ulster University; Ulster University; Ollscoil na Gaillimhe-University
   of Galway
RP Kaur, D (corresponding author), Ulster Univ, Biomed Sci Res Inst, Northern Ireland Ctr Stratified Med, C TRIC, Altnagelvin Hosp Site, Derry Londonderry BT47 6SB, Ireland.
EM kaur-d1@ulster.ac.uk
RI Bucholc, Magda/ABF-9272-2020
OI Bucholc, Magda/0000-0002-8417-1602; Kaur, Daman
   Preet/0009-0004-2752-6843; McClean, Paula/0000-0002-3906-1172; Wong-Lin,
   KongFatt/0000-0001-8724-4398
FU European Union [IVA 5036]; Northern Ireland Functional Brain Mapping
   Project Facility - Northern Ireland [1303/101154803]; University of
   Ulster; Alzheimer's Research UK (ARUK) NI Pump Priming; Ulster
   University Research Challenge Fund; Dr George Moore Endowmentfor Data
   Science at Ulster University; COST Action Open Multiscale Systems
   Medicine (OpenMultiMed) - COST(European Cooperation in Science and
   Technology); NIA/NIH [U01 AG016976]; NIA [P30 AG019610, P30 AG013846,
   P50 AG008702, P50 AG025688, P50 AG047266, P30 AG010133, P50 AG005146,
   P50 AG005134, P50 AG016574, P50 AG005138, P30 AG008051, P30AG013854, P30
   AG008017, P30 AG010161, P50 AG047366, P30 AG010129]; The NIA [P50
   AG016573, P50 AG005131, P50 AG023501, P30 AG035982, P30 AG028383,
   P30AG053760, P30 AG010124, P50AG005133, P50AG005142, P30 AG012300, P30
   AG049638, P50 AG005136, P50 AG033514, P50 AG005681, P50 AG047270]
FX This project was supported by the European Union's INTERREG VA
   Programme, managed by the Special EU Programmes Body (SEUPB [Centre for
   Personalised Medicine, IVA 5036]), with additional support by
   theNorthern Ireland Functional Brain Mapping Project Facility
   (1303/101154803), funded by invest Northern Ireland and the University
   of Ulster (KongFatt Wong-Lin), Alzheimer's Research UK (ARUK) NI Pump
   Priming (Magda Bucholc, Stephen Todd, KongFattWong-Lin, Paula L.
   McClean), Ulster University Research Challenge Fund (Magda Bucholc,
   Stephen Todd, KongFatt Wong-Lin), the Dr George Moore Endowmentfor Data
   Science atUlsterUniversity (MagdaBucholc), and the COST Action
   OpenMultiscale Systems Medicine (OpenMultiMed) supported
   byCOST(EuropeanCooperation in Science and Technology; KongFatt
   Wong-Lin). The views and opinions expressed in this article do not
   necessarily reflect those of the European Commission or the SEUPB. The
   NACC database is funded by NIA/NIH Grant U01 AG016976. NACC data are
   contributed by the NIA-funded ADCs: P30 AG019610 (PI Eric Reiman, MD),
   P30 AG013846 (PI Neil Kowall, MD), P50 AG008702 (PI Scott Small, MD),
   P50 AG025688 (PI Allan Levey, MD, PhD), P50 AG047266 (PI Todd Golde, MD,
   PhD), P30 AG010133 (PI Andrew Saykin, PsyD), P50 AG005146 (PI Marilyn
   Albert, PhD), P50 AG005134 (PI Bradley Hyman, MD, PhD), P50 AG016574 (PI
   Ronald Petersen, MD, PhD), P50 AG005138 (PIMary Sano, PhD), P30 AG008051
   (PI Thomas Wisniewski, MD), P30AG013854 (PIM. Marsel Mesulam, MD), P30
   AG008017 (PI Jeffrey Kaye, MD), P30 AG010161 (PI David Bennett, MD), P50
   AG047366 (PI Victor Henderson, MD, MS), P30 AG010129 (PI Charles
   DeCarli, MD), P50 AG016573 (PI Frank LaFerla, PhD), P50 AG005131 (PI
   James Brewer, MD, PhD), P50 AG023501 (PI Bruce Miller, MD), P30 AG035982
   (PI Russell Swerdlow, MD), P30 AG028383 (PI Linda Van Eldik, PhD),
   P30AG053760 (PI Henry Paulson, MD, PhD), P30 AG010124 (PI John
   Trojanowski, MD, PhD), P50AG005133 (PIOscar Lopez, MD), P50AG005142
   (PIHelena Chui, MD), P30 AG012300 (PI Roger Rosenberg, MD), P30 AG049638
   (PI Suzanne Craft, PhD), P50 AG005136 (PI Thomas Grabowski, MD), P50
   AG033514 (PI Sanjay Asthana, MD, FRCP), P50 AG005681 (PI John Morris,
   MD), P50 AG047270 (PI Stephen Strittmatter, MD, PhD).
CR Anttila T, 2004, BMJ-BRIT MED J, V329, P539, DOI 10.1136/bmj.38181.418958.BE
   Artero S, 2008, J NEUROL NEUROSUR PS, V79, P979, DOI 10.1136/jnnp.2007.136903
   BACHMAN DL, 1992, NEUROLOGY, V42, P115, DOI 10.1212/WNL.42.1.115
   Baker E, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0178562
   Baker M, 2016, NATURE, V533, P452, DOI 10.1038/533452a
   Baumgart M, 2015, ALZHEIMERS DEMENT, V11, P718, DOI 10.1016/j.jalz.2015.05.016
   Beekly DL, 2004, ALZ DIS ASSOC DIS, V18, P270
   Benjamini Y, 2001, ANN STAT, V29, P1165
   Bennett S, 2014, MATURITAS, V79, P184, DOI 10.1016/j.maturitas.2014.05.009
   Bermejo-Pareja F, 2010, J ALZHEIMERS DIS, V22, P949, DOI 10.3233/JAD-2010-101110
   Berr C, 2005, EUR NEUROPSYCHOPHARM, V15, P463, DOI 10.1016/j.euroneuro.2005.04.003
   CAIN KC, 1992, STAT MED, V11, P783, DOI 10.1002/sim.4780110609
   Corrada MM, 2017, ALZHEIMERS DEMENT, V13, P103, DOI 10.1016/j.jalz.2016.09.007
   Crowe M, 2010, J AGING HEALTH, V22, P292, DOI 10.1177/0898264309357445
   Deckers K, 2015, INT J GERIATR PSYCH, V30, P234, DOI 10.1002/gps.4245
   Ding XM, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-27997-8
   Edwards GA III, 2019, FRONT AGING NEUROSCI, V11, DOI 10.3389/fnagi.2019.00146
   Enache D, 2011, CURR OPIN PSYCHIATR, V24, P461, DOI 10.1097/YCO.0b013e32834bb9d4
   Frost C, 2005, INT J EPIDEMIOL, V34, P1359, DOI 10.1093/ije/dyi148
   Ganguli M, 2013, NEUROLOGY, V80, P2112, DOI 10.1212/WNL.0b013e318295d776
   Ganguli M, 2010, ARCH NEUROL-CHICAGO, V67, P107, DOI 10.1001/archneurol.2009.311
   Guerreiro R, 2015, GENOME MED, V7, DOI 10.1186/s13073-015-0232-5
   Ilomäki J, 2015, CURR CLIN PHARMACOL, V10, P204, DOI 10.2174/157488471003150820145539
   Ismail Z, 2017, JAMA PSYCHIAT, V74, P58, DOI 10.1001/jamapsychiatry.2016.3162
   Jefferson AL, 2015, CIRCULATION, V131, P1333, DOI 10.1161/CIRCULATIONAHA.114.012438
   KETY SS, 1948, J CLIN INVEST, V27, P511, DOI 10.1172/JCI101998
   KETY SS, 1946, AM J MED SCI, V212, P124
   Knuiman MW, 1998, ANN EPIDEMIOL, V8, P56, DOI 10.1016/S1047-2797(97)00107-5
   Leonard BE, 2007, NEUROCHEM RES, V32, P1749, DOI 10.1007/s11064-007-9385-y
   McGuinness B, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD004034.pub3
   Mielke MM, 2010, NEUROLOGY, V75, P1888, DOI 10.1212/WNL.0b013e3181feb2bf
   Mirza SS, 2016, LANCET PSYCHIAT, V3, P628, DOI 10.1016/S2215-0366(16)00097-3
   Moore PJ, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0222212
   Muliyala KP, 2010, ANN INDIAN ACAD NEUR, V13, P69, DOI 10.4103/0972-2327.74248
   Oveisgharan S, 2010, ARCH NEUROL-CHICAGO, V67, P187, DOI 10.1001/archneurol.2009.312
   Panza F, 2010, AM J GERIAT PSYCHIAT, V18, P98, DOI 10.1097/JGP.0b013e3181b0fa13
   Qizilbash N, 2015, LANCET DIABETES ENDO, V3, P431, DOI 10.1016/S2213-8587(15)00033-9
   Rehm J, 2019, ALZHEIMERS RES THER, V11, DOI 10.1186/s13195-018-0453-0
   Ruitenberg A, 2001, NEUROBIOL AGING, V22, P575, DOI 10.1016/S0197-4580(01)00231-7
   Sano M, 2017, J AM GERIATR SOC, V65, P2198, DOI 10.1111/jgs.15014
   Shi L, 2011, BRIT J NUTR, V105, P747, DOI 10.1017/S0007114510004307
   Solomon A, 2009, DEMENT GERIATR COGN, V28, P75, DOI 10.1159/000231980
   Thiese MS, 2016, J THORAC DIS, V8, pE928, DOI 10.21037/jtd.2016.08.16
   Todd S, 2013, INT J GERIATR PSYCH, V28, P1109, DOI 10.1002/gps.3946
   Tyas SL, 2003, NEUROBIOL AGING, V24, P589, DOI 10.1016/S0197-4580(02)00156-2
   Viswanathan A, 2015, ALZ DIS ASSOC DIS, V29, P287, DOI 10.1097/WAD.0000000000000080
   Wiels W, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00034
   WILLETT W, 1989, STAT MED, V8, P1031, DOI 10.1002/sim.4780080903
   Wilson RS, 2014, NEUROLOGY, V83, P702, DOI 10.1212/WNL.0000000000000715
   Zhong GC, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0118333
NR 50
TC 4
Z9 4
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2352-8729
J9 ALZH DEMENT-DADM
JI Alzheimers Dement.-Diagn. Assess. Dis. Monit.
PY 2020
VL 12
IS 1
AR e12116
DI 10.1002/dad2.12116
PG 13
WC Clinical Neurology; Neurosciences
WE Emerging Sources Citation Index (ESCI)
SC Neurosciences & Neurology
GA WG7VU
UT WOS:000707203600112
PM 33088897
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Aghamohammadzadeh, R
   Withers, S
   Lynch, F
   Greenstein, A
   Malik, R
   Heagerty, A
AF Aghamohammadzadeh, Reza
   Withers, Sarah
   Lynch, Fiona
   Greenstein, Adam
   Malik, R.
   Heagerty, Anthony
TI Perivascular adipose tissue from human systemic and coronary vessels:
   the emergence of a new pharmacotherapeutic target
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Review
DE perivascular adipose tissue; PVAT; adipocytes; adipokines; obesity;
   metabolic syndrome; adiponectin; leptin; epicardial adipose tissue;
   coronary vessels
ID RENIN-ANGIOTENSIN SYSTEM; SPONTANEOUSLY HYPERTENSIVE-RATS;
   CONVERTING-ENZYME INHIBITION; VASCULAR ENDOTHELIAL-CELLS; NITRIC-OXIDE
   SYNTHASE; INSULIN-RESISTANCE; METABOLIC-SYNDROME; ADIPONECTIN RECEPTORS;
   OXIDATIVE STRESS; ARTERY-DISEASE
AB Fat cells or adipocytes are distributed ubiquitously throughout the body and are often regarded purely as energy stores. However, recently it has become clear that these adipocytes are engine rooms producing large numbers of metabolically active substances with both endocrine and paracrine actions. White adipocytes surround almost every blood vessel in the human body and are collectively termed perivascular adipose tissue (PVAT). It is now well recognized that PVAT not only provides mechanical support for any blood vessels it invests, but also secretes vasoactive and metabolically essential cytokines known as adipokines, which regulate vascular function. The emergence of obesity as a major challenge to our healthcare systems has contributed to the growing interest in adipocyte dysfunction with a view to discovering new pharmacotherapeutic agents to help rescue compromised PVAT function. Very few PVAT studies have been carried out on human tissue. This review will discuss these and the hypotheses generated from such research, as well as highlight the most significant and clinically relevant animal studies showing the most pharmacological promise.
C1 [Heagerty, Anthony] Univ Manchester, Cardiovasc Res Grp, Div Cardiovasc & Endocrine Sci, Core Technol Facil Floor 3, Manchester M13 9NT, Lancs, England.
C3 University of Manchester
RP Heagerty, A (corresponding author), Univ Manchester, Cardiovasc Res Grp, Div Cardiovasc & Endocrine Sci, Core Technol Facil Floor 3, 46 Grafton St, Manchester M13 9NT, Lancs, England.
EM tony.heagerty@manchester.ac.uk
RI Malik, Rayaz/H-9231-2019
OI Heagerty, Anthony/0000-0002-9043-2119; Aghamohammadzadeh,
   Reza/0000-0002-6058-9078; Malik, Rayaz/0000-0002-7188-8903; Withers,
   Sarah/0000-0002-7021-881X; Greenstein, Adam/0000-0002-5274-4189
FU Manchester Wellcome Trust
FX Our group is supported by the Manchester Wellcome Trust Clinical
   Research Facility and Dr Aghamohammadzadeh is a British Heart Foundation
   and NIHR Manchester Biomedical Research Centre Clinical Research Fellow.
CR [Anonymous], CLIN CORNERSTONE
   Asayama K, 2003, OBES RES, V11, P1072, DOI 10.1038/oby.2003.147
   Baker AR, 2006, CARDIOVASC DIABETOL, V5, DOI 10.1186/1475-2840-5-1
   Bakker ENTP, 2006, CIRC RES, V99, P86, DOI 10.1161/01.RES.0000229657.83816.a7
   Berg AH, 2001, NAT MED, V7, P947, DOI 10.1038/90992
   BULOW J, 1987, ACTA PHYSIOL SCAND, V130, P657, DOI 10.1111/j.1748-1716.1987.tb08189.x
   CAMPBELL DJ, 1993, HYPERTENSION, V22, P513, DOI 10.1161/01.HYP.22.4.513
   CAMPBELL DJ, 1995, J CARDIOVASC PHARM, V26, P426, DOI 10.1097/00005344-199509000-00013
   Cassis L A, 2000, Curr Hypertens Rep, V2, P132, DOI 10.1007/s11906-000-0072-5
   CASSIS LA, 1988, CIRC RES, V62, P1259, DOI 10.1161/01.RES.62.6.1259
   Chatterjee TK, 2009, CIRC RES, V104, P541, DOI 10.1161/CIRCRESAHA.108.182998
   Chen BY, 2006, BIOCHEM BIOPH RES CO, V341, P549, DOI 10.1016/j.bbrc.2006.01.004
   COPPACK SW, 1992, METABOLISM, V41, P264, DOI 10.1016/0026-0495(92)90269-G
   Crandall DL, 1999, ENDOCRINOLOGY, V140, P154, DOI 10.1210/en.140.1.154
   Dashwood MR, 2007, J VASC RES, V44, P175, DOI 10.1159/000099833
   Dashwood MR, 2009, J THORAC CARDIOV SUR, V138, P334, DOI 10.1016/j.jtcvs.2008.11.060
   DAVIES GC, 1980, CIRCULATION, V61, P808, DOI 10.1161/01.CIR.61.4.808
   Davis Kathryn E, 2008, Biochem J, V416, pe7, DOI 10.1042/BJ20082033
   de Chantemèle EJB, 2009, CARDIOVASC RES, V81, P788, DOI 10.1093/cvr/cvn334
   Deng G, 2010, INT J OBESITY, V34, P165, DOI 10.1038/ijo.2009.205
   Deng Y., 2011, ANN NY ACAD SCI, V1212, pE1
   Diamond J, 2003, NATURE, V423, P599, DOI 10.1038/423599a
   Dridi S, 2009, J NUTR BIOCHEM, V20, P831, DOI 10.1016/j.jnutbio.2009.06.003
   Egner I, 2010, P BRIT PHARM SOC, V8
   Eiras S, 2008, CYTOKINE, V43, P174, DOI 10.1016/j.cyto.2008.05.006
   Engeli S, 2003, INT J BIOCHEM CELL B, V35, P807, DOI 10.1016/S1357-2725(02)00311-4
   Engeli S, 1999, J HYPERTENS, V17, P555, DOI 10.1097/00004872-199917040-00014
   Eringa EC, 2004, AM J PHYSIOL-HEART C, V287, pH2043, DOI 10.1152/ajpheart.00067.2004
   Ferrario CM, 2005, AM J PHYSIOL-HEART C, V289, pH2281, DOI 10.1152/ajpheart.00618.2005
   Fésüs G, 2007, CARDIOVASC RES, V75, P719, DOI 10.1016/j.cardiores.2007.05.025
   Fox CS, 2007, CIRCULATION, V116, P39, DOI 10.1161/CIRCULATIONAHA.106.675355
   Frühbeck G, 1999, DIABETES, V48, P903, DOI 10.2337/diabetes.48.4.903
   Fukai N, 2005, AM J PHYSIOL-ENDOC M, V288, pE56, DOI 10.1152/ajpendo.00586.2003
   Galvez B, 2006, ARTERIOSCL THROM VAS, V26, P1297, DOI 10.1161/01.ATV.0000220381.40739.dd
   Galvez-Prieto B, 2008, J ENDOCRINOL, V197, P55, DOI 10.1677/JOE-07-0284
   Gao YJ, 2007, BRIT J PHARMACOL, V151, P323, DOI 10.1038/sj.bjp.0707228
   Gao YJ, 2005, J THORAC CARDIOV SUR, V130, P1130, DOI 10.1016/j.jtcvs.2005.05.028
   Gao YJ, 2005, OBES RES, V13, P687, DOI 10.1038/oby.2005.77
   Gao YJ, 2006, CARDIOVASC RES, V71, P363, DOI 10.1016/j.cardiores.2006.03.013
   Gesta S, 2007, CELL, V131, P242, DOI 10.1016/j.cell.2007.10.004
   Gettys TW, 1996, ENDOCRINOLOGY, V137, P4054, DOI 10.1210/en.137.9.4054
   Giacchetti G, 2002, AM J HYPERTENS, V15, P381, DOI 10.1016/S0895-7061(02)02257-4
   Gorzelniak K, 2002, J HYPERTENS, V20, P965, DOI 10.1097/00004872-200205000-00032
   Greenstein AS, 2009, CIRCULATION, V119, P1661, DOI 10.1161/CIRCULATIONAHA.108.821181
   Greif M, 2009, ARTERIOSCL THROM VAS, V29, P781, DOI 10.1161/ATVBAHA.108.180653
   Han SH, 2009, PROG CARDIOVASC DIS, V52, P126, DOI 10.1016/j.pcad.2009.06.004
   Harmancey R, 2005, FASEB J, V19, P1045, DOI 10.1096/fj.04-2868fje
   HARP JB, 1995, J GERONTOL A-BIOL, V50, pB270, DOI 10.1093/gerona/50A.5.B270
   HE GW, 1994, J THORAC CARDIOV SUR, V107, P1440, DOI 10.1016/S0022-5223(94)70420-1
   Holvoet P, 2008, JAMA-J AM MED ASSOC, V299, P2287, DOI 10.1001/jama.299.19.2287
   Hosogai N, 2007, DIABETES, V56, P901, DOI 10.2337/db06-0911
   Huang FY, 2010, CLIN EXP HYPERTENS, V32, P98, DOI 10.3109/10641960902993129
   Hughes JM, 2010, AM J PHYSIOL-HEART C, V299, pH1439, DOI 10.1152/ajpheart.00124.2010
   Hwang SJ, 1997, CIRCULATION, V96, P4219
   Iacobellis G, 2005, CYTOKINE, V29, P251, DOI 10.1016/j.cyto.2004.11.002
   Iacobellis G, 2003, J CLIN ENDOCR METAB, V88, P5163, DOI 10.1210/jc.2003-030698
   Iacobellis G, 2003, OBES RES, V11, P304, DOI 10.1038/oby.2003.45
   Iacobellis G, 2009, HORM METAB RES, V41, P227, DOI 10.1055/s-0028-1100412
   Iacobellis G, 2008, OBESITY, V16, P887, DOI 10.1038/oby.2008.6
   IOTF, 2010, OB GLOB EP, V2010
   Jonsson J R, 1994, Blood Press, V3, P72
   Kadowaki T, 2005, ENDOCR REV, V26, P439, DOI 10.1210/er.2005-0005
   Kadowaki T, 2006, J CLIN INVEST, V116, P1784, DOI 10.1172/JCI29126
   Kanda H, 2006, J CLIN INVEST, V116, P1494, DOI 10.1172/JCI26498
   Kawanami D, 2004, BIOCHEM BIOPH RES CO, V314, P415, DOI 10.1016/j.bbrc.2003.12.104
   Kern PA, 2003, DIABETES, V52, P1779, DOI 10.2337/diabetes.52.7.1779
   Knudson JD, 2005, AM J PHYSIOL-HEART C, V289, pH48, DOI 10.1152/ajpheart.01159.2004
   Lambert E, 2010, HYPERTENSION, V56, P351, DOI 10.1161/HYPERTENSIONAHA.110.155663
   Lee RMKW, 2009, J HYPERTENS, V27, P782, DOI 10.1097/HJH.0b013e328324ed86
   Lee RMKW, 2009, J HYPERTENS, V27, P118, DOI 10.1097/HJH.0b013e3283163cc9
   Lembo G, 2000, DIABETES, V49, P293, DOI 10.2337/diabetes.49.2.293
   Liu QQ, 2010, FASEB J, V24, P4229, DOI 10.1096/fj.10-159723
   Löhn M, 2002, FASEB J, V16, P1057, DOI 10.1096/fj.02-0024com
   Long QQ, 2010, ENDOCRINOLOGY, V151, P3195, DOI 10.1210/en.2009-1501
   Lu C, 2011, EUR J PHARMACOL, V656, P68, DOI 10.1016/j.ejphar.2011.01.023
   Lu C, 2011, EUR J PHARMACOL, V657, P111, DOI 10.1016/j.ejphar.2010.12.028
   Lu C, 2010, EUR J PHARMACOL, V634, P107, DOI 10.1016/j.ejphar.2010.02.006
   Lynch F, 2010, J HYPERTENS, V28, pE177, DOI 10.1097/01.hjh.0000378748.11779.d1
   Lynch F, 2010, CIRCULATION, V122
   Maeda N, 2002, NAT MED, V8, P731, DOI 10.1038/nm724
   Maenhaut N, 2010, EUR J PHARMACOL, V641, P207, DOI 10.1016/j.ejphar.2010.05.058
   Malinowski M, 2008, EUR J CARDIO-THORAC, V33, P225, DOI 10.1016/j.ejcts.2007.11.007
   Manka D, 2010, CIRCULATION, V122
   Manolopoulos KN, 2010, INT J OBESITY, V34, P949, DOI 10.1038/ijo.2009.286
   Matsuda M, 2002, J BIOL CHEM, V277, P37487, DOI 10.1074/jbc.M206083200
   Mazurek T, 2003, CIRCULATION, V108, P2460, DOI 10.1161/01.CIR.0000099542.57313.C5
   Mizukawa M, 2009, HYPERTENS RES, V32, P617, DOI 10.1038/hr.2009.63
   Momin AU, 2006, EUR HEART J, V27, P2294, DOI 10.1093/eurheartj/ehi831
   Motoshima H, 2004, BIOCHEM BIOPH RES CO, V315, P264, DOI 10.1016/j.bbrc.2004.01.049
   Nagaya N, 2000, HEART, V84, P653, DOI 10.1136/heart.84.6.653
   Nagaya N, 2003, HYPERTENS RES, V26, pS141, DOI 10.1291/hypres.26.S141
   Nakamura M, 1997, CIRCULATION, V95, P1214
   NEEL JV, 1962, AM J HUM GENET, V14, P353
   NUKI C, 1993, BIOCHEM BIOPH RES CO, V196, P245, DOI 10.1006/bbrc.1993.2241
   Ohashi K, 2006, HYPERTENSION, V47, P1108, DOI 10.1161/01.HYP.0000222368.43759.a1
   Ouchi N, 2003, HYPERTENSION, V42, P231, DOI 10.1161/01.HYP.0000083488.67550.B8
   Ouchi N, 1999, CIRCULATION, V100, P2473, DOI 10.1161/01.CIR.100.25.2473
   Ouedraogo R, 2006, DIABETES, V55, P1840, DOI 10.2337/db05-1174
   Pai JK, 2004, NEW ENGL J MED, V351, P2599, DOI 10.1056/NEJMoa040967
   Pajvani Utpal B, 2003, Curr Diab Rep, V3, P207, DOI 10.1007/s11892-003-0065-2
   Pasarica M, 2009, DIABETES, V58, P718, DOI 10.2337/db08-1098
   Patel L, 2003, BIOCHEM BIOPH RES CO, V300, P472, DOI 10.1016/S0006-291X(02)02841-3
   Payne GA, 2008, MICROCIRCULATION, V15, P417, DOI 10.1080/10739680701858447
   Payne GA, 2010, ARTERIOSCL THROM VAS, V30, P1711, DOI 10.1161/ATVBAHA.110.210070
   Payne GA, 2009, AM J PHYSIOL-HEART C, V297, pH460, DOI 10.1152/ajpheart.00116.2009
   Pischon T, 2004, JAMA-J AM MED ASSOC, V291, P1730, DOI 10.1001/jama.291.14.1730
   Police SB, 2009, ARTERIOSCL THROM VAS, V29, P1458, DOI 10.1161/ATVBAHA.109.192658
   PREZIO JA, 1964, J CLIN ENDOCR METAB, V24, P481, DOI 10.1210/jcem-24-6-481
   Rasmussen MS, 2006, OBESITY, V14, P28, DOI 10.1038/oby.2006.5
   Rausch ME, 2008, INT J OBESITY, V32, P451, DOI 10.1038/sj.ijo.0803744
   Ren J, 2004, J ENDOCRINOL, V181, P1, DOI 10.1677/joe.0.1810001
   Reudelhuber TL, 2006, HYPERTENSION, V47, P811, DOI 10.1161/01.HYP.0000209020.69734.73
   Robidoux J, 2006, J BIOL CHEM, V281, P37794, DOI 10.1074/jbc.M605572200
   Salgado-Somoza A, 2010, AM J PHYSIOL-HEART C, V299, pH202, DOI 10.1152/ajpheart.00120.2010
   Sam F, 2010, HEART, V96, P331, DOI 10.1136/hrt.2009.178590
   Schling P, 1999, INT J OBESITY, V23, P336, DOI 10.1038/sj.ijo.0800821
   Scott EM, 2006, DIABETOLOGIA, V49, P1462, DOI 10.1007/s00125-006-0280-x
   Shibasaki I, 2010, REGUL PEPTIDES, V165, P210, DOI 10.1016/j.regpep.2010.07.169
   Shimosawa T, 2003, HYPERTENSION, V41, P1080, DOI 10.1161/01.HYP.0000066846.46422.2C
   Silaghi A, 2007, AM J PHYSIOL-ENDOC M, V293, pE1443, DOI 10.1152/ajpendo.00273.2007
   Simons PJ, 2007, J ENDOCRINOL, V192, P289, DOI 10.1677/JOE-06-0047
   SOLTIS EE, 1991, CLIN EXP HYPERTENS A, V13, P277, DOI 10.3109/10641969109042063
   Sowers James R, 2008, Clin Cornerstone, V9, P32, DOI 10.1016/S1098-3597(08)60026-5
   Spiroglou SG, 2010, J ATHEROSCLER THROMB, V17, P115
   Sweeney G, 2010, NAT REV CARDIOL, V7, P22, DOI 10.1038/nrcardio.2009.224
   Teijeira-Fernandez E, 2008, J HUM HYPERTENS, V22, P856, DOI 10.1038/jhh.2008.75
   Terata K, 2000, AM J PHYSIOL-HEART C, V279, pH2620, DOI 10.1152/ajpheart.2000.279.6.H2620
   Trayhurn P, 2008, BRIT J NUTR, V100, P227, DOI 10.1017/S0007114508971282
   Vecchione C, 2003, HYPERTENSION, V42, P166, DOI 10.1161/01.HYP.0000082806.73530.68
   Verlohren S, 2004, HYPERTENSION, V44, P271, DOI 10.1161/01.HYP.0000140058.28994.ec
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Withers SB, 2011, ARTERIOSCL THROM VAS, V31, P908, DOI 10.1161/ATVBAHA.110.221705
   Yagil Y, 2003, HYPERTENSION, V41, P871, DOI 10.1161/01.HYP.0000063886.71596.C8
   Yamauchi T, 2003, NATURE, V423, P762, DOI 10.1038/nature01705
   Yamauchi T, 2003, J BIOL CHEM, V278, P2461, DOI 10.1074/jbc.M209033200
   Yamauchi T, 2001, NAT MED, V7, P941, DOI 10.1038/90984
   Yokota T, 2000, BLOOD, V96, P1723, DOI 10.1182/blood.V96.5.1723
   Yoshimoto T, 2005, HYPERTENS RES, V28, P165, DOI 10.1291/hypres.28.165
   Yudkin JS, 2005, LANCET, V365, P1817, DOI 10.1016/S0140-6736(05)66585-3
NR 139
TC 82
Z9 86
U1 2
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD FEB
PY 2012
VL 165
IS 3
SI SI
BP 670
EP 682
DI 10.1111/j.1476-5381.2011.01479.x
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 874JS
UT WOS:000298953100011
PM 21564083
OA Green Published
DA 2025-06-11
ER

PT J
AU Berardo, C
   Di Pasqua, LG
   Cagna, M
   Richelmi, P
   Vairetti, M
   Ferrigno, A
AF Berardo, Clarissa
   Di Pasqua, Laura Giuseppina
   Cagna, Marta
   Richelmi, Plinio
   Vairetti, Mariapia
   Ferrigno, Andrea
TI Nonalcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis:
   Current Issues and Future Perspectives in Preclinical and Clinical
   Research
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE non-alcoholic fatty liver disease; metabolic syndrome; steatohepatitis;
   hepatocellular carcinoma; steatosis
ID ACTIVATED RECEPTOR-ALPHA; HEPATIC STELLATE CELLS; ASYMMETRIC
   DIMETHYLARGININE ADMA; DE-NOVO LIPOGENESIS; IN-VITRO MODEL; PPAR-ALPHA;
   INSULIN-RESISTANCE; CHOLINE-DEFICIENT; OXIDATIVE STRESS;
   LIPID-METABOLISM
AB Nonalcoholic fatty liver disease (NAFLD) is a continuum of liver abnormalities often starting as simple steatosis and to potentially progress into nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis and hepatocellular carcinoma. Because of its increasing prevalence, NAFLD is becoming a major public health concern, in parallel with a worldwide increase in the recurrence rate of diabetes and metabolic syndrome. It has been estimated that NASH cirrhosis may surpass viral hepatitis C and become the leading indication for liver transplantation in the next decades. The broadening of the knowledge about NASH pathogenesis and progression is of pivotal importance for the discovery of new targeted and more effective therapies; aim of this review is to offer a comprehensive and updated overview on NAFLD and NASH pathogenesis, the most recommended treatments, drugs under development and new drug targets. The most relevant in vitro and in vivo models of NAFLD and NASH will be also reviewed, as well as the main molecular pathways involved in NAFLD and NASH development.
C1 [Berardo, Clarissa; Di Pasqua, Laura Giuseppina; Cagna, Marta; Richelmi, Plinio; Vairetti, Mariapia; Ferrigno, Andrea] Univ Pavia, Unit Cellular & Mol Pharmacol & Toxicol, Dept Internal Med & Therapeut, I-27100 Pavia, Italy.
C3 University of Pavia
RP Di Pasqua, LG; Ferrigno, A (corresponding author), Univ Pavia, Unit Cellular & Mol Pharmacol & Toxicol, Dept Internal Med & Therapeut, I-27100 Pavia, Italy.
EM clarissa.berardo01@universitadipavia.it;
   lauragiuseppin.dipasqua01@universitadipavia.it;
   marta.cagna02@universitadipavia.it; plinio.richelmi@unipv.it;
   mariapia.vairetti@unipv.it; andrea.ferrigno@unipv.it
RI Cagna, Marta/AAD-4143-2021; Vairetti, Mariapia/AAM-1757-2020; Ferrigno,
   Andrea/J-2087-2019; Di Pasqua, Laura/Y-3987-2019; Berardo,
   Clarissa/U-7316-2019
OI Di Pasqua, Laura Giuseppina/0000-0003-0103-1493; Ferrigno,
   Andrea/0000-0003-2337-2897; Berardo, Clarissa/0000-0002-1257-5843;
   Vairetti, Mariapia/0000-0002-2464-6127
CR Abd-Elrahman KS, 2019, MOL BRAIN, V12, DOI 10.1186/s13041-019-0456-1
   Adinolfi LE, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17060803
   Alkhouri N, 2016, METABOLISM, V65, P1087, DOI 10.1016/j.metabol.2016.01.013
   Allen LN, 2017, LANCET GLOB HEALTH, V5, pE129, DOI 10.1016/S2214-109X(17)30001-3
   Anstee QM, 2006, INT J EXP PATHOL, V87, P1, DOI 10.1111/j.0959-9673.2006.00465.x
   Armstrong MJ, 2016, LANCET, V387, P679, DOI 10.1016/S0140-6736(15)00803-X
   Arun J, 2006, OBES SURG, V16, P1351, DOI 10.1381/096089206778663715
   Astrup A, 2009, LANCET, V374, P1606, DOI 10.1016/S0140-6736(09)61375-1
   Baggio LL, 2007, GASTROENTEROLOGY, V132, P2131, DOI 10.1053/j.gastro.2007.03.054
   Bakan I, 2012, CURR OPIN LIPIDOL, V23, P226, DOI 10.1097/MOL.0b013e328352dd03
   Barbero-Becerra VJ, 2015, TOXICOL IN VITRO, V29, P1753, DOI 10.1016/j.tiv.2015.07.010
   Barreyro FJ, 2015, LIVER INT, V35, P953, DOI 10.1111/liv.12570
   Begriche K, 2013, HEPATOLOGY, V58, P1497, DOI 10.1002/hep.26226
   Bertot LC, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17050774
   Bockaert J, 2015, PHYSIOL REV, V95, P1157, DOI 10.1152/physrev.00038.2014
   Boga S, 2015, J INVEST MED, V63, P871, DOI 10.1097/JIM.0000000000000230
   Bojic LA, 2013, CURR OPIN LIPIDOL, V24, P171, DOI 10.1097/MOL.0b013e32835cc949
   Bradbury MJ, 2005, J PHARMACOL EXP THER, V313, P395, DOI 10.1124/jpet.104.076406
   Buzzetti E, 2016, METABOLISM, V65, P1038, DOI 10.1016/j.metabol.2015.12.012
   Caldwell S, 2017, CLIN MOL HEPATOL, V23, P103, DOI 10.3350/cmh.2017.0103
   Caron A, 2015, ANNU REV NUTR, V35, P321, DOI 10.1146/annurev-nutr-071714-034355
   Charlton M, 2013, CURR OPIN ORGAN TRAN, V18, P251, DOI 10.1097/MOT.0b013e3283615d30
   Chavez-Tapia NC, 2011, CURR MED CHEM, V18, P1079
   Choi WM, 2019, CELL METAB, V30, P877, DOI 10.1016/j.cmet.2019.08.001
   Chong C, 2015, GASTROENTEROLOGY, V148, pS1043, DOI 10.1016/S0016-5085(15)33561-7
   Collison KS, 2009, J LIPID RES, V50, P1521, DOI 10.1194/jlr.M800418-JLR200
   Croce AC, 2016, J PHOTOCH PHOTOBIO B, V164, P13, DOI 10.1016/j.jphotobiol.2016.09.015
   Croce AC, 2017, HEPATOL RES, V47, P668, DOI 10.1111/hepr.12779
   Cui W, 2010, AM J TRANSL RES, V2, P95
   Cusi K, 2009, CLIN LIVER DIS, V13, P545, DOI 10.1016/j.cld.2009.07.009
   Davidson MD, 2017, INTEGR BIOL-UK, V9, P662, DOI 10.1039/c7ib00027h
   Day C P, 2002, J Gastroenterol Hepatol, V17 Suppl 3, pS377, DOI 10.1046/j.1440-1746.17.s3.31.x
   Di Pasqua LG, 2016, MOL CELL BIOCHEM, V419, P147, DOI 10.1007/s11010-016-2758-2
   Dogru T, 2012, DIABETES RES CLIN PR, V96, P47, DOI 10.1016/j.diabres.2011.11.022
   Düvel K, 2010, MOL CELL, V39, P171, DOI 10.1016/j.molcel.2010.06.022
   Dyson JK, 2014, FRONTLINE GASTROENTE, V5, P211, DOI 10.1136/flgastro-2013-100403
   EASL, 2016, OBESITY FACTS, V9, P65, DOI [10.1159/000443344, 10.1007/s00125-016-3902-y, 10.1016/j.jhep.2015.11.004]
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Ekstedt M, 2006, HEPATOLOGY, V44, P865, DOI 10.1002/hep.21327
   Elsheikh E, 2014, J GASTROEN HEPATOL, V29, P1528, DOI 10.1111/jgh.12549
   Eslam M, 2020, J HEPATOL, V73, P202, DOI 10.1016/j.jhep.2020.03.039
   Esler WP, 2019, CELL MOL GASTROENTER, V8, P247, DOI 10.1016/j.jcmgh.2019.04.007
   Fabbrini E, 2008, GASTROENTEROLOGY, V134, P424, DOI 10.1053/j.gastro.2007.11.038
   Feldstein A, 2004, AM J GASTROENTEROL, V99, P1718, DOI 10.1111/j.1572-0241.2004.40573.x
   Feldstein AE, 2009, HEPATOLOGY, V50, P1072, DOI 10.1002/hep.23050
   Fellmann L, 2013, PHARMACOL THERAPEUT, V137, P331, DOI 10.1016/j.pharmthera.2012.11.004
   Fernández-Alvarez A, 2011, J BIOL CHEM, V286, P21466, DOI 10.1074/jbc.M110.209973
   Ferraguti F, 2006, CELL TISSUE RES, V326, P483, DOI 10.1007/s00441-006-0266-5
   Ferraioli G, 2019, WORLD J GASTROENTERO, V25, P6053, DOI 10.3748/wjg.v25.i40.6053
   Ferrigno A, 2020, EUR J HISTOCHEM, V64, P285, DOI 10.4081/ejh.2020.3175
   Ferrigno A, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19010109
   Ferrigno A, 2015, WORLD J GASTROENTERO, V21, P5131, DOI 10.3748/wjg.v21.i17.5131
   Foster DW, 2012, J CLIN INVEST, V122, P1958, DOI 10.1172/JCI63967
   Fouad Y, 2020, LIVER INT, V40, P1254, DOI 10.1111/liv.14478
   Friedman SL, 2018, NAT MED, V24, P908, DOI 10.1038/s41591-018-0104-9
   Garcia-Tsao G, 2020, J HEPATOL, V72, P885, DOI 10.1016/j.jhep.2019.12.010
   Giraudi PJ, 2015, EXP MOL PATHOL, V98, P85, DOI 10.1016/j.yexmp.2014.12.006
   Godoy-Matos AF, 2020, DIABETOL METAB SYNDR, V12, DOI 10.1186/s13098-020-00570-y
   Golabi P, 2018, MEDICINE, V97, DOI [10.1097/MD.0000000000010214, 10.1097/md.0000000000010214]
   Gómez-Lechón MJ, 2007, CHEM-BIOL INTERACT, V165, P106, DOI 10.1016/j.cbi.2006.11.004
   Grabacka M, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17122093
   Guilherme A, 2008, NAT REV MOL CELL BIO, V9, P367, DOI 10.1038/nrm2391
   Hajri T, 2002, ANNU REV NUTR, V22, P383, DOI 10.1146/annurev.nutr.22.020402.130846
   Hamilton JA, 2001, J MOL NEUROSCI, V16, P99, DOI 10.1385/JMN:16:2-3:99
   Han JB, 2015, NATURE, V524, P243, DOI 10.1038/nature14557
   Harrison SA, 2020, J HEPATOL, V73, P26, DOI 10.1016/j.jhep.2020.02.027
   Hebbard L, 2011, NAT REV GASTRO HEPAT, V8, P34, DOI 10.1038/nrgastro.2010.191
   Hernández A, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9040817
   Hirsova P, 2016, J LIPID RES, V57, P1758, DOI 10.1194/jlr.R066357
   Hollman DAA, 2012, BBA-MOL CELL BIOL L, V1821, P1443, DOI 10.1016/j.bbalip.2012.07.004
   Horton JD, 1999, J CLIN INVEST, V103, P1067, DOI 10.1172/JCI6246
   Horton JD, 2002, J CLIN INVEST, V109, P1125, DOI 10.1172/JCI200215593
   Hou LF, 2004, J NEUROSCI, V24, P6352, DOI 10.1523/JNEUROSCI.0995-04.2004
   Houten SM, 2010, J INHERIT METAB DIS, V33, P469, DOI 10.1007/s10545-010-9061-2
   Huang JF, 2020, LIVER INT, V40, P2880, DOI 10.1111/liv.14656
   Hurrell T, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9040964
   Ikawa-Yoshida A, 2017, INT J EXP PATHOL, V98, P221, DOI 10.1111/iep.12240
   Imajo K, 2013, INT J MOL SCI, V14, P21833, DOI 10.3390/ijms141121833
   Ip E, 2004, HEPATOLOGY, V39, P1286, DOI 10.1002/hep.20170
   Ipsen DH, 2018, CELL MOL LIFE SCI, V75, P3313, DOI 10.1007/s00018-018-2860-6
   Iqbal Umair, 2019, Medicines (Basel), V6, DOI 10.3390/medicines6010041
   Ishii M, 2015, ARCH BIOCHEM BIOPHYS, V566, P26, DOI 10.1016/j.abb.2014.12.009
   Jiao M, 2014, CELL DEATH DIS, V5, DOI 10.1038/cddis.2014.361
   Jinjuvadia R, 2017, J CLIN GASTROENTEROL, V51, P160, DOI 10.1097/MCG.0000000000000666
   Jump DB, 2013, ANNU REV NUTR, V33, P249, DOI 10.1146/annurev-nutr-071812-161139
   Kawamata Y, 2003, J BIOL CHEM, V278, P9435, DOI 10.1074/jbc.M209706200
   Kersten S, 2008, PPAR RES, V2008, DOI 10.1155/2008/132960
   Kersten S, 2014, MOL METAB, V3, P354, DOI 10.1016/j.molmet.2014.02.002
   Khalil Rania M, 2016, Neurosignals, V24, P81, DOI 10.1159/000442614
   Kim CW, 2017, CELL METAB, V26, P394, DOI 10.1016/j.cmet.2017.07.009
   Kim D, 2016, CLIN GASTROENTEROL H, V14, P132, DOI 10.1016/j.cgh.2015.07.024
   Knight BL, 2005, BIOCHEM J, V389, P413, DOI 10.1042/BJ20041896
   Knudsen LB, 2000, J MED CHEM, V43, P1664, DOI 10.1021/jm9909645
   Kohli R, 2010, HEPATOLOGY, V52, P934, DOI 10.1002/hep.23797
   Koo SH, 2013, CLIN MOL HEPATOL, V19, P210, DOI 10.3350/cmh.2013.19.3.210
   Kornek M, 2012, GASTROENTEROLOGY, V143, P448, DOI 10.1053/j.gastro.2012.04.031
   Kucera O, 2014, WORLD J GASTROENTERO, V20, P8364, DOI 10.3748/wjg.v20.i26.8364
   Lambert JE, 2014, GASTROENTEROLOGY, V146, P726, DOI 10.1053/j.gastro.2013.11.049
   Lamichane S, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19040949
   Laplante M, 2009, J CELL SCI, V122, P3589, DOI 10.1242/jcs.051011
   Lazennec G, 2000, MOL ENDOCRINOL, V14, P1962, DOI 10.1210/me.14.12.1962
   Lefebvre P, 2009, PHYSIOL REV, V89, P147, DOI 10.1152/physrev.00010.2008
   Lindström P, 2007, THESCIENTIFICWORLDJO, V7, P666, DOI 10.1100/tsw.2007.117
   Lippman SM, 2009, JAMA-J AM MED ASSOC, V301, P39, DOI 10.1001/jama.2008.864
   Liss KHH, 2017, BIOCHIMIE, V136, P65, DOI 10.1016/j.biochi.2016.11.009
   Lonardo A., 2020, Explor Med, V1, P85
   Lonardo A, 2020, J CLIN MED, V9, DOI 10.3390/jcm9051278
   Longato L, 2013, FIBROGENESIS TISSUE, V6, DOI 10.1186/1755-1536-6-14
   Loomba R, 2018, HEPATOLOGY, V67, P549, DOI 10.1002/hep.29514
   Maddineni S, 2013, EXP BIOL MED, V238, P392, DOI 10.1177/1535370213477988
   Maeda T, 2008, BIOL PHARM BULL, V31, P1230, DOI 10.1248/bpb.31.1230
   Mahady SE, 2011, J HEPATOL, V55, P1383, DOI 10.1016/j.jhep.2011.03.016
   Makishima M, 1999, SCIENCE, V284, P1362, DOI 10.1126/science.284.5418.1362
   Mamikutty N, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/263897
   Mandard S, 2004, CELL MOL LIFE SCI, V61, P393, DOI 10.1155/2010/612089
   Mansouri RM, 2008, ENDOCRINOLOGY, V149, P3215, DOI 10.1210/en.2007-1339
   Marino L, 2015, WORLD J GASTROENTERO, V21, P11053, DOI 10.3748/wjg.v21.i39.11053
   Matsuzawa N, 2007, HEPATOLOGY, V46, P1392, DOI 10.1002/hep.21874
   Mittal S, 2015, CLIN GASTROENTEROL H, V13, P594, DOI 10.1016/j.cgh.2014.08.013
   Mudaliar S, 2013, GASTROENTEROLOGY, V145, P574, DOI 10.1053/j.gastro.2013.05.042
   Mukai T, 2017, FEBS OPEN BIO, V7, P1009, DOI 10.1002/2211-5463.12240
   Mullard A, 2020, NAT REV DRUG DISCOV, V19, P501, DOI [10.1038/d41573-020-00126-9, 10.1038/d41573-020-00127-8]
   Munteanu Mihai Alexandru, 2016, Clujul Med, V89, P19, DOI 10.15386/cjmed-539
   Musso G, 2010, HEPATOLOGY, V52, P79, DOI 10.1002/hep.23623
   Nakanishi Y, 2008, J AUTOIMMUN, V30, P42, DOI 10.1016/j.jaut.2007.11.016
   Nakayama H, 2007, METABOLISM, V56, P470, DOI 10.1016/j.metabol.2006.11.004
   Natarajan V, 2017, BIOMED RES INT, V2017, DOI 10.1155/2017/4097205
   Neuschwander-Tetri BA, 2015, LANCET, V386, P28, DOI 10.1016/S0140-6736(15)61200-4
   Neuschwander-Tetri BA, 2015, LANCET, V385, P956, DOI 10.1016/S0140-6736(14)61933-4
   Newsome PN, 2021, NEW ENGL J MED, V384, P1113, DOI 10.1056/NEJMoa2028395
   Odegaard JI, 2008, CELL METAB, V7, P496, DOI 10.1016/j.cmet.2008.04.003
   Oseini AM, 2018, HEPATOL INT, V12, P6, DOI 10.1007/s12072-017-9838-6
   Otgonsuren M, 2013, DIGEST DIS SCI, V58, P1132, DOI 10.1007/s10620-012-2446-3
   Ouchi R, 2019, CELL METAB, V30, P374, DOI 10.1016/j.cmet.2019.05.007
   Pan MH, 2004, J CLIN INVEST, V113, P1277, DOI 10.1172/JCI200419197
   Pawlak M, 2015, J HEPATOL, V62, P720, DOI 10.1016/j.jhep.2014.10.039
   Perla FM, 2017, CHILDREN-BASEL, V4, DOI 10.3390/children4060046
   Peterson TR, 2011, CELL, V146, P408, DOI 10.1016/j.cell.2011.06.034
   Peverill W, 2014, INT J MOL SCI, V15, P8591, DOI 10.3390/ijms15058591
   Pingitore P, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20071629
   Polyzos SA, 2020, METABOLISM, V113, DOI 10.1016/j.metabol.2020.154413
   Porstmann T, 2008, CELL METAB, V8, P224, DOI 10.1016/j.cmet.2008.07.007
   Povero D, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0113651
   Prashanth M, 2009, J Assoc Physicians India, V57, P205
   Prior N, 2019, GUT, V68, P2228, DOI 10.1136/gutjnl-2019-319256
   Pyper Sean R, 2010, Nucl Recept Signal, V8, pe002, DOI 10.1621/nrs.08002
   Qu Q, 2016, CELL DEATH DIS, V7, DOI 10.1038/cddis.2016.132
   Rao MS, 2001, SEMIN LIVER DIS, V21, P43, DOI 10.1055/s-2001-12928
   Ratziu V, 2016, GASTROENTEROLOGY, V150, P1147, DOI 10.1053/j.gastro.2016.01.038
   Ratziu V, 2010, HEPATOLOGY, V52, P2206, DOI 10.1002/hep.24042
   Reid DT, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0159524
   Richir MC, 2008, JPEN-PARENTER ENTER, V32, P613, DOI 10.1177/0148607108321702
   Ronesi JA, 2008, J NEUROSCI, V28, P543, DOI 10.1523/JNEUROSCI.5019-07.2008
   Sahebkar A, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2018-021508
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Sangüesa G, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20051117
   Santhekadur PK, 2018, J HEPATOL, V68, P230, DOI 10.1016/j.jhep.2017.10.031
   Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929
   Saremi A, 2010, AM J THER, V17, pE56, DOI 10.1097/MJT.0b013e31819cdc9a
   Satapathy SK, 2015, ANN HEPATOL, V14, P789, DOI 10.5604/16652681.1171749
   SCHAFFNER F, 1986, PROG LIVER DIS, V8, P283
   Schonfeld G, 2003, J LIPID RES, V44, P470, DOI 10.1194/jlr.M200342-JLR200
   Schoonjans K, 1996, EMBO J, V15, P5336, DOI 10.1002/j.1460-2075.1996.tb00918.x
   Schwenk RW, 2010, PROSTAG LEUKOTR ESS, V82, P149, DOI 10.1016/j.plefa.2010.02.029
   Sengupta S, 2010, NATURE, V468, P1100, DOI 10.1038/nature09584
   Shelness GS, 2001, CURR OPIN LIPIDOL, V12, P151, DOI 10.1097/00041433-200104000-00008
   Smith SK, 2018, CLIN LIVER DIS, V22, P723, DOI 10.1016/j.cld.2018.07.001
   Solinas G, 2015, MOL METAB, V4, P367, DOI 10.1016/j.molmet.2015.03.004
   Spruss A, 2009, HEPATOLOGY, V50, P1094, DOI 10.1002/hep.23122
   Staels B, 2013, HEPATOLOGY, V58, P1941, DOI 10.1002/hep.26461
   Stepanova M, 2013, DIGEST DIS SCI, V58, P3017, DOI 10.1007/s10620-013-2743-5
   Stepanova M, 2010, GUT, V59, P1410, DOI 10.1136/gut.2010.213553
   Tang CR, 2003, J LIPID RES, V44, P686, DOI 10.1194/jlr.M200195-JLR200
   Tang JT, 2020, J DIGEST DIS, V21, P3, DOI 10.1111/1751-2980.12830
   Targher G, 2020, LIVER INT, V40, P2879, DOI 10.1111/liv.14623
   Trak-Smayra V, 2011, INT J EXP PATHOL, V92, P413, DOI 10.1111/j.1365-2613.2011.00793.x
   Van Meeteren MJW, 2020, EXPERT OPIN INV DRUG, V29, P117, DOI 10.1080/13543784.2020.1668375
   Verdam FJ, 2013, J HEPATOL, V58, P543, DOI 10.1016/j.jhep.2012.10.030
   Veteläinen R, 2007, J GASTROEN HEPATOL, V22, P1526, DOI 10.1111/j.1440-1746.2006.04701.x
   Vilar-Gomez E, 2015, GASTROENTEROLOGY, V149, P367, DOI 10.1053/j.gastro.2015.04.005
   Wang HB, 1999, MOL CELL, V3, P543, DOI 10.1016/S1097-2765(00)80348-2
   Wang YP, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21062061
   Washington K, 2000, HUM PATHOL, V31, P822, DOI 10.1053/hupa.2000.8440
   Wieckowska A, 2006, HEPATOLOGY, V44, P27, DOI 10.1002/hep.21223
   Willard SS, 2013, INT J BIOL SCI, V9, P948, DOI 10.7150/ijbs.6426
   Wilson CG, 2016, ENDOCRINOLOGY, V157, P570, DOI 10.1210/en.2015-1866
   Wortham M, 2008, DIGEST DIS SCI, V53, P2761, DOI 10.1007/s10620-007-0193-7
   Xu PF, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19041260
   Yang YY, 2012, HEPATOLOGY, V55, P1540, DOI 10.1002/hep.25534
   Yilmaz Y, 2012, ALIMENT PHARM THER, V36, P815, DOI 10.1111/apt.12046
   Yin S, 2014, CELL SIGNAL, V26, P2284, DOI 10.1016/j.cellsig.2014.04.022
   Yoon M, 2009, PHARMACOL RES, V60, P151, DOI 10.1016/j.phrs.2009.02.004
   Younossi Z, 2018, NAT REV GASTRO HEPAT, V15, P11, DOI 10.1038/nrgastro.2017.109
   Younossi ZM, 2019, LANCET, V394, P2184, DOI 10.1016/S0140-6736(19)33041-7
   Younossi ZM, 2019, J HEPATOL, V71, P793, DOI 10.1016/j.jhep.2019.06.021
   Younossi Zobair M, 2018, Clin Liver Dis (Hoboken), V11, P92, DOI 10.1002/cld.710
   Younossi ZM, 2019, TRANSPLANTATION, V103, P22, DOI 10.1097/TP.0000000000002484
   Younossi ZM, 2013, METABOLISM, V62, P352, DOI 10.1016/j.metabol.2012.08.005
   Younossi ZM, 2011, HEPATOLOGY, V53, P1874, DOI 10.1002/hep.24268
   Yu GS, 1998, J BIOL CHEM, V273, P32901, DOI 10.1074/jbc.273.49.32901
   Yu J, 2006, HEPATOLOGY, V43, P826, DOI 10.1002/hep.21108
   Zhang XY, 2017, P NATL ACAD SCI USA, V114, P3181, DOI 10.1073/pnas.1700172114
   Zhong F, 2020, DIGESTION, V101, P522, DOI 10.1159/000501851
   Zhou GC, 2001, J CLIN INVEST, V108, P1167, DOI 10.1172/JCI13505
   Zhou YY, 2016, SCI REP-UK, V6, DOI 10.1038/srep33743
   Zhou YP, 2018, NUTR METAB, V15, DOI 10.1186/s12986-018-0268-9
   Zhu CY, 2014, INT J CLIN EXP PATHO, V7, P6807
NR 207
TC 48
Z9 51
U1 1
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2020
VL 21
IS 24
AR 9646
DI 10.3390/ijms21249646
PG 29
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA PL1RZ
UT WOS:000602909200001
PM 33348908
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Dini, L
   Tacconi, S
   Carata, E
   Tata, AM
   Vergallo, C
   Panzarini, E
AF Dini, L.
   Tacconi, S.
   Carata, E.
   Tata, A. M.
   Vergallo, C.
   Panzarini, E.
TI Microvesicles and exosomes in metabolic diseases and inflammation
SO CYTOKINE & GROWTH FACTOR REVIEWS
LA English
DT Review
DE Metabolic disorders; Inflammation; Extracellular vesicles; M1
   macrophages; M2 macrophages
ID ADIPOSE-TISSUE MACROPHAGES; EXTRACELLULAR VESICLES; INSULIN-RESISTANCE;
   FATTY-ACIDS; ENDOTHELIAL-CELLS; SKELETAL-MUSCLE; DENDRITIC CELLS;
   OBESITY; INDUCE; EXPRESSION
AB Metabolic diseases are based on a dysregulated crosstalk between various cells such as adipocytes, hepatocytes and immune cells. Generally, hormones and metabolites mediate this crosstalk that becomes alterated in metabolic syndrome including obesity and diabetes. Recently, Extracellular Vesicles (EVs) are emerging as a novel way of cell-to-cell communication and represent an attractive strategy to transfer fundamental informations between the cells through the transport of proteins and nucleic acids. EVs, released in the extracellular space, circulate via the various body fluids and modulate the cellular responses following their interaction with the near and far target cells. Clinical and experimental data support their role as biomarkers and bioeffectors in several diseases includimg also the metabolic syndrome. Despite numerous studies on the role of macrophages in the development of metabolic diseases, to date, there are little informations about the influence of metabolic stress on the EVs produced by macrophages and about the role of the released vesicles in the organism. Here, we review current understanding about the role of EVs in metabolic diseases, mainly in inflammation status burst. This knowledge may play a relevant role in health monitoring, medical diagnosis and personalized medicine.
C1 [Dini, L.; Tata, A. M.] Sapienza Univ Rome, Dept Biol & Biotechnol C Darwin, Piazzale Aldo Moro 5, I-00185 Rome, Italy.
   [Dini, L.] CNR Nanotec, Lecce, Italy.
   [Tacconi, S.; Carata, E.; Panzarini, E.] Univ Salento, Dept Biol & Environm Sci & Technol DiSTeBA, Via Prov Le Lecce Monteroni, I-73100 Lecce, Italy.
   [Tata, A. M.] Sapienza Univ Rome, Res Ctr Neurobiol Daniel Bovet, Rome, Italy.
   [Vergallo, C.] Univ Chieti Pescara G dAnnunzio, Dept Pharm, Chieti, Italy.
C3 Sapienza University Rome; Consiglio Nazionale delle Ricerche (CNR);
   Istituto di Nanotecnologia (NANOTEC-CNR); University of Salento;
   Sapienza University Rome; G d'Annunzio University of Chieti-Pescara
RP Dini, L (corresponding author), Sapienza Univ Rome, Dept Biol & Biotechnol C Darwin, Piazzale Aldo Moro 5, I-00185 Rome, Italy.; Panzarini, E (corresponding author), Univ Salento, Dept Biol & Environm Sci & Technol DiSTeBA, Via Prov Le Lecce Monteroni, I-73100 Lecce, Italy.
EM luciana.dini@uniroma1.it; elisa.panzarini@unisalento.it
RI Tacconi, Stefano/JFJ-4278-2023; Vergallo, Cristian/J-4303-2019; CARATA,
   Elisabetta/J-9621-2016
OI CARATA, Elisabetta/0000-0002-3801-5457; Vergallo,
   Cristian/0000-0002-0264-4753
CR Agouni A, 2008, AM J PATHOL, V173, P1210, DOI 10.2353/ajpath.2008.080228
   Agouni A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027809
   Akash MSH, 2018, J CELL BIOCHEM, V119, P105, DOI 10.1002/jcb.26174
   Andrade VL, 2012, CLIN BIOCHEM, V45, P412, DOI 10.1016/j.clinbiochem.2012.01.008
   Andrés NL, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0039235
   Arkan MC, 2005, NAT MED, V11, P191, DOI 10.1038/nm1185
   Aswad H, 2014, DIABETOLOGIA, V57, P2155, DOI 10.1007/s00125-014-3337-2
   Baer DJ, 2004, AM J CLIN NUTR, V79, P969
   Blanc Lionel, 2018, Small GTPases, V9, P95, DOI 10.1080/21541248.2016.1264352
   Bolukbasi MF, 2012, MOL THER-NUCL ACIDS, V1, DOI 10.1038/mtna.2011.2
   Botha J, 2017, J DIABETES RES, V2017, DOI 10.1155/2017/4257875
   Boulanger CM, 2017, NAT REV CARDIOL, V14, P259, DOI 10.1038/nrcardio.2017.7
   Burger D, 2011, ARTERIOSCL THROM VAS, V31, P1898, DOI 10.1161/ATVBAHA.110.222703
   Butcher MJ, 2014, DIABETOLOGIA, V57, P491, DOI 10.1007/s00125-013-3116-5
   Cancello R, 2006, DIABETES, V55, P1554, DOI 10.2337/db06-0133
   Chaturvedi P, 2015, J CELL MOL MED, V19, P2153, DOI 10.1111/jcmm.12589
   Chawla A, 2011, NAT REV IMMUNOL, V11, P738, DOI 10.1038/nri3071
   Chen Y, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms11420
   Choi Y, 2015, SCI REP-UK, V5, DOI 10.1038/srep15878
   Cinti S, 2005, J LIPID RES, V46, P2347, DOI 10.1194/jlr.M500294-JLR200
   Collins KH, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00112
   Coumans FAW, 2017, CIRC RES, V120, P1632, DOI 10.1161/CIRCRESAHA.117.309417
   Cucak H, 2014, J LEUKOCYTE BIOL, V95, P149, DOI 10.1189/jlb.0213075
   Cullberg KB, 2014, NUTR DIABETES, V4, DOI 10.1038/nutd.2014.10
   Daryabor G, 2019, SCAND J IMMUNOL, V89, DOI 10.1111/sji.12747
   Delic D, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0150154
   Deng ZB, 2009, DIABETES, V58, P2498, DOI 10.2337/db09-0216
   Devaraj S, 2005, DIABETES, V54, P85, DOI 10.2337/diabetes.54.1.85
   Dey A, 2015, FRONT IMMUNOL, V5, DOI 10.3389/fimmu.2014.00683
   Durcin M, 2017, J EXTRACELL VESICLES, V6, DOI 10.1080/20013078.2017.1305677
   Elgazar-Carmon V, 2008, J LIPID RES, V49, P1894, DOI 10.1194/jlr.M800132-JLR200
   Farooqi AA, 2018, BIOTECHNOL ADV, V36, P328, DOI 10.1016/j.biotechadv.2017.12.010
   Fernández-Real JM, 2003, DIABETES CARE, V26, P1362, DOI 10.2337/diacare.26.5.1362
   Fink LN, 2014, OBESITY, V22, P747, DOI 10.1002/oby.20615
   Galic S, 2011, J CLIN INVEST, V121, P4903, DOI 10.1172/JCI58577
   Gao W, 2016, J CELL MOL MED, V20, P2318, DOI 10.1111/jcmm.12923
   Garcia-Romero N, 2018, MOL ASPECTS MED, V60, P27, DOI 10.1016/j.mam.2017.11.009
   Gho YS, 2017, MOL BIOSYST, V13, P1291, DOI 10.1039/c7mb00146k
   Helal O, 2011, NUTR METAB CARDIOVAS, V21, P665, DOI 10.1016/j.numecd.2010.01.004
   Hirsova P, 2016, GASTROENTEROLOGY, V150, P956, DOI 10.1053/j.gastro.2015.12.037
   Hong EG, 2009, DIABETES, V58, P2525, DOI 10.2337/db08-1261
   Huang ZH, 2013, J LIPID RES, V54, P202, DOI 10.1194/jlr.M031906
   Huang-Doran I, 2017, TRENDS ENDOCRIN MET, V28, P3, DOI 10.1016/j.tem.2016.10.003
   Hugel B, 2005, PHYSIOLOGY, V20, P22, DOI 10.1152/physiol.00029.2004
   Huynh K, 2018, METABOLITES, V8, DOI 10.3390/metabo8020029
   Ieronymaki E, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.01330
   Igoillo-Esteve M, 2010, DIABETOLOGIA, V53, P1395, DOI 10.1007/s00125-010-1707-y
   Jansen F, 2013, CIRCULATION, V128, P2026, DOI 10.1161/CIRCULATIONAHA.113.001720
   Ji LQ, 2019, INT J ONCOL, V55, P103, DOI 10.3892/ijo.2019.4800
   Jiang XC, 2017, INT J PHARMACEUT, V521, P167, DOI 10.1016/j.ijpharm.2017.02.038
   Jin X, 2015, BIOMED RES INT, V2015, DOI 10.1155/2015/732450
   Kanatsuka A, 2018, DIABETOL INT, V9, P143, DOI 10.1007/s13340-018-0347-1
   Khan IM, 2015, INT J OBESITY, V39, P1607, DOI 10.1038/ijo.2015.104
   Kim DK, 2013, J EXTRACELL VESICLES, V2, DOI 10.3402/jev.v2i0.20384
   Koeck ES, 2014, J SURG RES, V192, P268, DOI 10.1016/j.jss.2014.06.050
   Kowal J, 2016, P NATL ACAD SCI USA, V113, pE968, DOI 10.1073/pnas.1521230113
   Kranendonk MEG, 2014, OBESITY, V22, P1296, DOI 10.1002/oby.20679
   Kranendonk MEG, 2014, CARDIOVASC DIABETOL, V13, DOI 10.1186/1475-2840-13-37
   Kratz M, 2014, CELL METAB, V20, P614, DOI 10.1016/j.cmet.2014.08.010
   Kuwabara Y, 2011, CIRC-CARDIOVASC GENE, V4, P446, DOI 10.1161/CIRCGENETICS.110.958975
   La Marca V, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18091974
   Lanthier N, 2010, AM J PHYSIOL-GASTR L, V298, pG107, DOI 10.1152/ajpgi.00391.2009
   Larsen CM, 2007, NEW ENGL J MED, V356, P1517, DOI 10.1056/NEJMoa065213
   Lee JY, 2003, J LIPID RES, V44, P479, DOI 10.1194/jlr.M200361-JLR200
   Lee JY, 2001, J BIOL CHEM, V276, P16683, DOI 10.1074/jbc.M011695200
   Leroux A, 2012, J HEPATOL, V57, P141, DOI 10.1016/j.jhep.2012.02.028
   Li LC, 2016, BIOCHEM BIOPH RES CO, V479, P343, DOI 10.1016/j.bbrc.2016.09.078
   Li SY, 2016, CELL PHYSIOL BIOCHEM, V39, P2439, DOI 10.1159/000452512
   Liu SR, 2016, CELL HOST MICROBE, V19, P32, DOI 10.1016/j.chom.2015.12.005
   Lumeng CN, 2007, J CLIN INVEST, V117, P175, DOI 10.1172/JCI29881
   Lumeng CN, 2008, DIABETES, V57, P3239, DOI 10.2337/db08-0872
   Magnuson AM, 2017, CELL PROLIFERAT, V50, DOI 10.1111/cpr.12365
   Mahdi T, 2012, CELL METAB, V16, P625, DOI 10.1016/j.cmet.2012.10.009
   Mantovani A, 2011, NAT REV IMMUNOL, V11, P519, DOI 10.1038/nri3024
   Martin AP, 2008, DIABETES, V57, P3025, DOI 10.2337/db08-0625
   Melo SA, 2015, NATURE, V523, P177, DOI 10.1038/nature14581
   Milbank E, 2015, J EXTRACELL VESICLES, V4, DOI 10.3402/jev.v4.28621
   Mulcahy LA, 2014, J EXTRACELL VESICLES, V3, DOI 10.3402/jev.v3.24641
   Musilli C, 2011, MOL IMMUNOL, V49, P234, DOI 10.1016/j.molimm.2011.08.019
   Nandy D, 2011, J INVEST MED, V59, P661, DOI 10.2310/JIM.0b013e31820ee432
   Nemes K, 2017, CURR OPIN LIPIDOL, V28, P355, DOI 10.1097/MOL.0000000000000427
   Nguyen MTA, 2007, J BIOL CHEM, V282, P35279, DOI 10.1074/jbc.M706762200
   Ogawa R, 2010, BIOCHEM BIOPH RES CO, V398, P723, DOI 10.1016/j.bbrc.2010.07.008
   Osada-Oka M, 2017, HYPERTENS RES, V40, P353, DOI 10.1038/hr.2016.163
   Ousmaal ME, 2016, J DIABETES COMPLICAT, V30, P21, DOI 10.1016/j.jdiacomp.2015.09.017
   Panfoli I, 2018, EXPERT REV PROTEOMIC, V15, P801, DOI 10.1080/14789450.2018.1528149
   Patsouris D, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0110653
   Pellegrinelli V, 2015, DIABETES, V64, P3121, DOI 10.2337/db14-0796
   Povero D, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0113651
   Pullen TJ, 2011, MOL CELL BIOL, V31, P3182, DOI 10.1128/MCB.01433-10
   Rask-Madsen C, 2012, ARTERIOSCL THROM VAS, V32, P2052, DOI 10.1161/ATVBAHA.111.241919
   Reilly SM, 2017, NAT REV ENDOCRINOL, V13, P633, DOI 10.1038/nrendo.2017.90
   Rojas J, 2018, J DIABETES RES, V2018, DOI 10.1155/2018/9601801
   Safiedeen Z, 2017, ANTIOXID REDOX SIGN, V26, P15, DOI 10.1089/ars.2016.6771
   Sag D, 2008, J IMMUNOL, V181, P8633, DOI 10.4049/jimmunol.181.12.8633
   Schilling JD, 2013, J BIOL CHEM, V288, P2923, DOI 10.1074/jbc.M112.419978
   Schönfeld P, 2008, FREE RADICAL BIO MED, V45, P231, DOI 10.1016/j.freeradbiomed.2008.04.029
   Shanmugam N, 2004, DIABETES, V53, P795, DOI 10.2337/diabetes.53.3.795
   Shanmugam N, 2003, DIABETES, V52, P1256, DOI 10.2337/diabetes.52.5.1256
   Stepanian A, 2013, OBESITY, V21, P2236, DOI 10.1002/oby.20365
   Taylor DD, 2008, GYNECOL ONCOL, V110, P13, DOI 10.1016/j.ygyno.2008.04.033
   Théry C, 2009, NAT REV IMMUNOL, V9, P581, DOI 10.1038/nri2567
   Thomou T, 2017, NATURE, V542, P450, DOI 10.1038/nature21365
   Togliatto G, 2016, INT J OBESITY, V40, P102, DOI 10.1038/ijo.2015.123
   Torres-Castro I, 2016, IMMUNOL LETT, V176, P81, DOI 10.1016/j.imlet.2016.06.001
   van Balkom BWM, 2013, BLOOD, V121, P3997, DOI 10.1182/blood-2013-02-478925
   van Niel G, 2018, NAT REV MOL CELL BIO, V19, P213, DOI 10.1038/nrm.2017.125
   van Niel G, 2011, DEV CELL, V21, P708, DOI 10.1016/j.devcel.2011.08.019
   Viola A, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.01462
   Vlassov AV, 2012, BBA-GEN SUBJECTS, V1820, P940, DOI 10.1016/j.bbagen.2012.03.017
   Weisberg SP, 2003, J CLIN INVEST, V112, P1796, DOI 10.1172/JCI200319246
   Wentworth JM, 2010, DIABETES, V59, P1648, DOI 10.2337/db09-0287
   Wu MX, 2017, P NATL ACAD SCI USA, V114, P10584, DOI 10.1073/pnas.1709210114
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yuan YJ, 2019, CLIN SCI, V133, P1759, DOI 10.1042/CS20190672
   Yvan-Charvet L, 2011, KIDNEY INT, V79, P162, DOI 10.1038/ki.2010.391
   Zhang YW, 2017, J IMMUNOL, V198, P798, DOI 10.4049/jimmunol.1601403
   Zhu YP, 2015, J IMMUNOL, V194, P584, DOI 10.4049/jimmunol.1401024
   Zu LY, 2016, INT J CARDIOL, V202, P756, DOI 10.1016/j.ijcard.2015.10.035
   Zubiri I, 2014, J PROTEOMICS, V96, P92, DOI 10.1016/j.jprot.2013.10.037
NR 120
TC 56
Z9 60
U1 5
U2 29
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1359-6101
EI 1879-0305
J9 CYTOKINE GROWTH F R
JI Cytokine Growth Factor Rev.
PD FEB
PY 2020
VL 51
SI SI
BP 27
EP 39
DI 10.1016/j.cytogfr.2019.12.008
PG 13
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA KN0YO
UT WOS:000514566400005
PM 31917095
DA 2025-06-11
ER

PT J
AU Oresic, M
AF Oresic, Matej
TI Systems biology strategy to study lipotoxicity and the metabolic
   syndrome
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
LA English
DT Review
DE Allostasis; Gene network; Lipid metabolism; Lipidomics; Metabolomics;
   Systems biology
ID MOLECULAR NETWORKS; OXIDATIVE STRESS; GENE-EXPRESSION; LIPIDOMICS;
   ALGORITHMS; RESPONSES; GENOMICS; OBESITY; SAMPLES; BRIDGE
AB Systems biology views and studies the biological systems in the context of complex interactions between their building blocks and processes. Given its multi-level complexity, metabolic syndrome (MetS) makes a strong case for adopting the systems biology approach. Despite many MetS traits being highly heritable, it is becoming evident that the genetic contribution to these traits is mediated via gene-gene and gene-environment interactions across several spatial and temporal scales, and that some of these traits such as lipotoxicity may even be a product of long-term dynamic changes of the underlying genetic and molecular networks. This presents several conceptual as well as methodological challenges and may demand a paradigm shift in how we study the undeniably strong genetic component of complex diseases such as MetS. The argument is made here that for adopting systems biology approaches to MetS an integrative framework is needed which glues the biological processes of MetS with specific physiological mechanisms and principles and that lipotoxicity is one such framework. The metabolic phenotypes, molecular and genetic networks can be modeled within the context of such integrative framework and the underlying physiology. (C) 2009 Elsevier B.V. All rights reserved.
C1 VTT Tech Res Ctr Finland, FIN-02044 Espoo, Vtt, Finland.
C3 VTT Technical Research Center Finland
RP Oresic, M (corresponding author), VTT Tech Res Ctr Finland, Tietotie 2,POB 1000, FIN-02044 Espoo, Vtt, Finland.
EM matej.oresic@vtt.fi
RI Oresic, Matej/K-7673-2016
OI Oresic, Matej/0000-0002-2856-9165
FU EU [FP7-KBBE-222639]; TORNADO [FP7-KBBE-222720]
FX This work was supported by the EU-funded projects ETHERPATHS
   (FP7-KBBE-222639, http://www.etherpaths.org/) and TORNADO
   (FP7-KBBE-222720, http://www.fp7tornado.eu/).
CR Alberts B, 2002, Molecular Biology of the Cell, V4th
   [Anonymous], MOL SYST BIOL
   Atherton HJ, 2009, MOL SYST BIOL, V5, DOI 10.1038/msb.2009.18
   Bäckhed F, 2010, BBA-MOL CELL BIOL L, V1801, P240, DOI 10.1016/j.bbalip.2009.09.009
   Bougnères P, 2008, J EXP MED, V205, P2953, DOI 10.1084/jem.20082622
   Breitling R, 2009, TRENDS ENDOCRIN MET, V20, P1, DOI 10.1016/j.tem.2008.08.006
   Chen YQ, 2008, NATURE, V452, P429, DOI 10.1038/nature06757
   Claus SP, 2008, MOL SYST BIOL, V4, DOI 10.1038/msb.2008.56
   Cui Z, 2009, J CHROMATOGR B, V877, P2709, DOI 10.1016/j.jchromb.2009.06.034
   Damian D, 2007, METABOLOMICS, V3, P69, DOI 10.1007/s11306-006-0045-z
   Duarte NC, 2007, P NATL ACAD SCI USA, V104, P1777, DOI 10.1073/pnas.0610772104
   Emilsson V, 2008, NATURE, V452, P423, DOI 10.1038/nature06758
   Fahy E, 2005, J LIPID RES, V46, P839, DOI 10.1194/jlr.E400004-JLR200
   Gasch AP, 2000, MOL BIOL CELL, V11, P4241, DOI 10.1091/mbc.11.12.4241
   Ge H, 2003, TRENDS GENET, V19, P551, DOI 10.1016/j.tig.2003.08.009
   Gopalacharyulu PV, 2009, MOL BIOSYST, V5, P276, DOI 10.1039/b815347g
   Han XL, 2009, J CHROMATOGR B, V877, P2663, DOI 10.1016/j.jchromb.2009.07.007
   Han XL, 2003, J LIPID RES, V44, P1071, DOI 10.1194/jlr.R300004-JLR200
   Haynes CA, 2009, J CHROMATOGR B, V877, P2696, DOI 10.1016/j.jchromb.2008.12.057
   Hicks AA, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000672
   Ideker T, 2001, ANNU REV GENOM HUM G, V2, P343, DOI 10.1146/annurev.genom.2.1.343
   Jamieson DJ, 1998, YEAST, V14, P1511, DOI 10.1002/(SICI)1097-0061(199812)14:16<1511::AID-YEA356>3.3.CO;2-J
   Kanehisa M, 2008, NUCLEIC ACIDS RES, V36, pD480, DOI 10.1093/nar/gkm882
   King RichardAllen., 2002, The Genetic Basis of Common Diseases
   Kitano H, 2004, DIABETES, V53, pS6, DOI 10.2337/diabetes.53.suppl_3.S6
   Kotronen A, 2010, OBESITY, V18, P937, DOI 10.1038/oby.2009.326
   Lagarde M, 2003, BBA-MOL CELL BIOL L, V1634, P61, DOI 10.1016/j.bbalip.2003.11.002
   Lelliott C, 2004, INT J OBESITY, V28, pS22, DOI 10.1038/sj.ijo.0802854
   Lusis AJ, 2008, NAT REV GENET, V9, P819, DOI 10.1038/nrg2468
   Maher B, 2008, NATURE, V456, P18, DOI 10.1038/456018a
   Medina-Gomez G, 2007, PLOS GENET, V3, DOI 10.1371/journal.pgen.0030064
   Mesaros C, 2009, J CHROMATOGR B, V877, P2736, DOI 10.1016/j.jchromb.2009.03.011
   Niemelä PS, 2007, PLOS COMPUT BIOL, V3, P304, DOI 10.1371/journal.pcbi.0030034
   Niemelä PS, 2009, J CHROMATOGR B, V877, P2855, DOI 10.1016/j.jchromb.2009.01.025
   Noble Denis., 2006, MUSIC LIFE BIOL GENO
   Oresic M, 2009, NUTR METAB CARDIOVAS, V19, P816, DOI 10.1016/j.numecd.2009.04.018
   Oresic M, 2006, EXPERT REV MOL DIAGN, V6, P575, DOI 10.1586/14737159.6.4.575
   Oresic M, 2008, J EXP MED, V205, P2975, DOI 10.1084/jem.20081800
   Oresic M, 2008, TRENDS BIOTECHNOL, V26, P647, DOI 10.1016/j.tibtech.2008.09.001
   Pietiläien KH, 2004, TWIN RES, V7, P421
   Pietiläinen KH, 2008, PLOS MED, V5, DOI 10.1371/journal.pmed.0050051
   Pietiläinen KH, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000218
   Puri P, 2007, HEPATOLOGY, V46, P1081, DOI 10.1002/hep.21763
   RABINER LR, 1989, P IEEE, V77, P257, DOI 10.1109/5.18626
   REDDY JK, 2003, ANNU REV NUTR, V21, P193
   Schadt EE, 2005, NAT GENET, V37, P710, DOI 10.1038/ng1589
   Schadt EE, 2009, NATURE, V461, P218, DOI 10.1038/nature08454
   Serhan CN, 2007, METHOD ENZYMOL, V432, P275, DOI 10.1016/S0076-6879(07)32012-0
   Song HW, 2009, J CHROMATOGR B, V877, P2847, DOI 10.1016/j.jchromb.2008.12.043
   Ståhlman M, 2009, J CHROMATOGR B, V877, P2664, DOI 10.1016/j.jchromb.2009.02.037
   Tang J, 2009, GENOME MED, V1, DOI [10.1186/gm204, 10.1186/gm35]
   Unger RH, 1997, TRENDS ENDOCRIN MET, V8, P276, DOI 10.1016/S1043-2760(97)00094-5
   Unger RH, 2001, FASEB J, V15, P312, DOI 10.1096/fj.00-0590
   van der Greef J, 2004, CURR OPIN CHEM BIOL, V8, P559, DOI 10.1016/j.cbpa.2004.08.013
   Virtue S, 2008, PLOS BIOL, V6, P1819, DOI 10.1371/journal.pbio.0060237
   Walley AJ, 2009, NAT REV GENET, V10, P431, DOI 10.1038/nrg2594
   Wenk MR, 2005, NAT REV DRUG DISCOV, V4, P594, DOI 10.1038/nrd1776
   Wheeler D, 2008, BRAIN, V131, P3092, DOI 10.1093/brain/awn190
   World Health Organization, 2000, World Health Organ Tech Rep Ser, DOI DOI 10.1596/0-1952-1129-4
   Yetukuri L, 2008, MOL BIOSYST, V4, P121, DOI 10.1039/b715468b
   Yetukuri L, 2007, BMC SYST BIOL, V1, DOI 10.1186/1752-0509-1-12
NR 61
TC 8
Z9 8
U1 0
U2 14
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1388-1981
EI 1879-2618
J9 BBA-MOL CELL BIOL L
JI Biochim. Biophys. Acta Mol. Cell Biol. Lipids
PD MAR
PY 2010
VL 1801
IS 3
SI SI
BP 235
EP 239
DI 10.1016/j.bbalip.2009.11.003
PG 5
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 568YT
UT WOS:000275563300006
PM 19944187
DA 2025-06-11
ER

PT J
AU Catar, RA
   Mueller, G
   Heidler, J
   Schmitz, G
   Bornstein, SR
   Morawietz, H
AF Catar, R. A.
   Mueller, G.
   Heidler, J.
   Schmitz, G.
   Bornstein, S. R.
   Morawietz, H.
TI Low-density lipoproteins induce the renin-angiotensin system and their
   receptors in human endothelial cells
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE endothelial cells; low-density lipoprotein; oxLDL receptor;
   renin-angiotensin system
ID NF-KAPPA-B; UP-REGULATION; OXIDIZED-LDL; CONVERTING ENZYME;
   GENE-EXPRESSION; SHEAR-STRESS; OX-LDL; ATHEROSCLEROSIS; LOX-1;
   TOLL-LIKE-RECEPTOR-4
AB Increased levels of low-density lipoproteins are well-established risk factors of endothelial dysfunction and the metabolic syndrome. In this study, we evaluated the effect of native low-density lipoprotein (nLDL) and oxidized LDL (oxLDL) on the expression of genes of the renin-angiotensin system (angiotensin-converting enzyme, ACE; angiotensin 11 type I receptor, AT,) and their receptors (low-density lipoprotein receptor: LDLR; lectin-like oxLDL receptor: LOX-1; toll-like receptor 4: TLR4) in primary cultures of human umbilical vein endothelial cells. ACE and AT, expressions were significantly increased after stimulation with nLDL and oxLDL. OxLDL receptor LOX-1 showed a maximum induction after 7 hours. Increased LOX-1 protein expression in response to oxLDL could be blocked by a LOX-1 specific antibody. TLR4 expression was increased by nLDL and oxLDL as well. We conclude that LDL and oxLDL can activate the renin-angiotensin system and their receptors LDLR, LOX-1, and TLR4 in human endothelial cells. These data suggest a novel link between hypercholesterolemia and hypertension in patients with the metabolic syndrome.
RP Morawietz, H (corresponding author), Tech Univ Dresden, Carl Gustav Carus Med Sch, Med Clin & Policlin III, Dept Vasc Endothelium & Microcirculat, Fetscherstasse 74, D-01307 Dresden, Germany.
EM Henning.Morawietz@tu-dresden.de
RI Catar, Rusan/I-3948-2019; Mueller, Gregor/F-3911-2010; Heidler,
   Juliana/MTE-0484-2025
OI Muller, Gregor/0009-0000-9791-1991; Catar, Rusan/0000-0002-7000-7860
CR Bonora E, 2006, ANN MED, V38, P64, DOI 10.1080/07853890500401234
   Bornstein SR, 2005, ARTERIOSCL THROM VAS, V25, pE135, DOI 10.1161/01.ATV.0000178996.91277.fb
   Bornstein SR, 2004, HORM METAB RES, V36, P470, DOI 10.1055/s-2004-825750
   Chen MJ, 2002, PHARMACOL THERAPEUT, V95, P89, DOI 10.1016/S0163-7258(02)00236-X
   Deedwania P, 2006, LANCET, V368, P919, DOI 10.1016/S0140-6736(06)69292-1
   Dhaliwal BS, 1999, CLIN CHIM ACTA, V286, P191, DOI 10.1016/S0009-8981(99)00101-1
   Dimmeler S, 1997, CIRCULATION, V95, P1760
   Faure E, 2000, J BIOL CHEM, V275, P11058, DOI 10.1074/jbc.275.15.11058
   Ferrario CM, 2002, AM J MED SCI, V323, P17, DOI 10.1097/00000441-200201000-00004
   Kjeldsen SE, 2004, AM HEART J, V148, P747, DOI 10.1016/j.ahj.2004.04.037
   Ko Y, 1997, BIOCHEM PHARMACOL, V53, P417, DOI 10.1016/S0006-2952(96)00691-0
   Kong WJ, 2006, J MOL MED, V84, P29, DOI 10.1007/s00109-005-0717-6
   Li DY, 2000, CIRCULATION, V102, P1970, DOI 10.1161/01.CIR.102.16.1970
   Li DY, 2003, CARDIOVASC RES, V57, P238, DOI 10.1016/S0008-6363(02)00674-0
   Li DY, 1999, CIRC RES, V84, P1043, DOI 10.1161/01.RES.84.9.1043
   Lonn EM, 2001, CIRCULATION, V103, P919
   Lusis AJ, 2000, NATURE, V407, P233, DOI 10.1038/35025203
   Mehta JL, 1998, BIOCHEM BIOPH RES CO, V248, P511, DOI 10.1006/bbrc.1998.9004
   Michelsen KS, 2004, P NATL ACAD SCI USA, V101, P10679, DOI 10.1073/pnas.0403249101
   Morawietz H, 1999, CIRCULATION, V100, P899, DOI 10.1161/01.CIR.100.9.899
   Muller G, 2007, Hamostaseologie, V27, P5
   Muller G, 2006, EXP BIOL MED, V231, P766
   Nickenig G, 1997, CIRCULATION, V95, P473
   Nickenig G, 2004, CIRCULATION, V110, P1013, DOI 10.1161/01.CIR.0000139857.85424.45
   Nickenig G, 1999, CIRCULATION, V100, P2131, DOI 10.1161/01.CIR.100.21.2131
   Nickenig G, 1997, J HYPERTENS, V15, pS27, DOI 10.1097/00004872-199715066-00006
   Niemann B, 2005, BIOCHEM BIOPH RES CO, V334, P747, DOI 10.1016/j.bbrc.2005.06.163
   Rueckschloss U, 2001, CIRCULATION, V104, P1767, DOI 10.1161/hc4001.097056
   Sawamura T, 1997, NATURE, V386, P73, DOI 10.1038/386073a0
   Schjoedt KJ, 2005, HORM METAB RES, V37, pS4, DOI 10.1055/s-2005-861359
   Schubert A, 2000, CIRC RES, V87, P1188, DOI 10.1161/01.RES.87.12.1188
   Strawn WB, 2000, CIRCULATION, V101, P1586, DOI 10.1161/01.CIR.101.13.1586
   Warnholtz A, 1999, CIRCULATION, V99, P2027, DOI 10.1161/01.CIR.99.15.2027
   Xu XH, 2001, CIRCULATION, V104, P3103, DOI 10.1161/hc5001.100631
   Yang QW, 2005, BIORHEOLOGY, V42, P225
NR 35
TC 46
Z9 51
U1 0
U2 8
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD NOV
PY 2007
VL 39
IS 11
BP 801
EP 805
DI 10.1055/s-2007-991158
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 239VF
UT WOS:000251545700006
PM 17992634
DA 2025-06-11
ER

PT J
AU Omidkhoda, N
   Mahdiani, S
   Hayes, AW
   Karimi, G
AF Omidkhoda, Navid
   Mahdiani, Sina
   Hayes, A. Wallace
   Karimi, Gholamreza
TI Natural compounds against nonalcoholic fatty liver disease: A review on
   the involvement of the LKB1/AMPK signaling pathway
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE AMPK; LKB1; NAFLD; NASH
ID EUTERPE-OLERACEA MART.; HEPATIC LIPID-ACCUMULATION; ACTIVATED
   PROTEIN-KINASE; GREEN TEA CATECHINS; CYNANCHUM-WILFORDII; COROSOLIC
   ACID; ZANTHOXYLUM-AILANTHOIDES; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS
AB Although various therapeutic approaches are used to manage nonalcoholic fatty liver disease (NAFLD), the best approach to NAFLD management is unclear. NAFLD is a liver disorder associated with obesity, metabolic syndrome, and diabetes mellitus. NAFLD progression can lead to cirrhosis and end-stage liver disease. Hepatic kinase B1 (LKB1) is an upstream kinase of 50-adenosine monophosphate-activated protein kinase (AMPK), a crucial regulator in hepatic lipid metabolism. Activation of LKB1/AMPK inhibits fatty acid synthesis, increases mitochondrial beta-oxidation, decreases the expression of genes encoding lipogenic enzymes, improves nonalcoholic steatohepatitis, and suppresses NAFLD progression. One potential opening for new and safe chemicals that can tackle the NAFLD pathogenesis through the LKB1-AMPK pathway includes natural bioactive compounds. Accordingly, we summarized in vitro and in vivo studies regarding the effect of natural bioactive compounds such as a few members of the polyphenols, terpenoids, alkaloids, and some natural extracts on NAFLD through the LKB1/AMPK signaling pathway. This manuscript may shed light on the way to finding a new therapeutic agent for NAFLD management.
C1 [Omidkhoda, Navid] Mashhad Univ Med Sci, Sch Pharm, Dept Clin Pharm, Mashhad, Iran.
   [Mahdiani, Sina; Karimi, Gholamreza] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Iran.
   [Hayes, A. Wallace] Univ S Florida, Coll Publ Hlth, Tampa, FL USA.
   [Hayes, A. Wallace] Michigan State Univ, Inst Integrat Toxicol, Lansing, MI 48824 USA.
   [Karimi, Gholamreza] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran.
   [Karimi, Gholamreza] Mashhad Univ Med Sci, Pharmaceut Res Ctr, Sch Pharm, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; State University System of Florida; University of South
   Florida; Michigan State University; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Karimi, G (corresponding author), Mashhad Univ Med Sci, Pharmaceut Res Ctr, Sch Pharm, Mashhad, Iran.
EM karimig@mums.ac.ir
RI karimi, gholamreza/B-8726-2017
OI Mahdiani, Sina/0000-0002-3098-8326; Omidkhoda, Navid/0000-0002-5310-0537
FU The authors are thankful to the Mashhad University of Medical Sciences.;
   Mashhad University of Medical Sciences
FX The authors are thankful to the Mashhad University of Medical Sciences.
CR Ahn J, 2021, CELL MOL GASTROENTER, V12, P1201, DOI 10.1016/j.jcmgh.2021.06.007
   Ahn J, 2012, MOL NUTR FOOD RES, V56, P1665, DOI 10.1002/mnfr.201200182
   Ajzashokouhi AH, 2023, CELL CYCLE, V22, P741, DOI 10.1080/15384101.2022.2161959
   Akram M, 2016, CHEM-BIOL INTERACT, V256, P102, DOI 10.1016/j.cbi.2016.06.029
   Alberdi G, 2013, NUTRITION, V29, P562, DOI 10.1016/j.nut.2012.09.011
   Allison AC, 2001, PROG NEURO-PSYCHOPH, V25, P1341, DOI 10.1016/S0278-5846(01)00192-0
   Alsahli MA, 2021, MEDIAT INFLAMM, V2021, DOI 10.1155/2021/6661937
   Anderson N, 2008, PHARMACOL REV, V60, P311, DOI 10.1124/pr.108.00001
   APITZCASTRO R, 1992, THROMB RES, V68, P145, DOI 10.1016/0049-3848(92)90030-E
   Bae UJ, 2018, AM J CHINESE MED, V46, P617, DOI [10.1142/s0192415x18500325, 10.1142/S0192415X18500325]
   Bagul PK, 2012, PHARMACOL RES, V66, P260, DOI 10.1016/j.phrs.2012.05.003
   Banerjee S, 2012, NUTR RES, V32, P985, DOI 10.1016/j.nutres.2012.10.005
   Bellentani S, 2017, LIVER INT, V37, P81, DOI 10.1111/liv.13299
   Bertot LC, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17050774
   Bladé C, 2016, BIOFACTORS, V42, P5, DOI 10.1002/biof.1249
   Bose M, 2008, J NUTR, V138, P1677, DOI 10.1093/jn/138.9.1677
   de Oliveira PRB, 2010, J CARDIOVASC PHARM, V56, P619, DOI 10.1097/FJC.0b013e3181f78da4
   Bullon P, 2014, PERIODONTOL 2000, V64, P139, DOI 10.1111/j.1600-0757.2012.00455.x
   Butt MS, 2015, CRIT REV FOOD SCI, V55, P792, DOI 10.1080/10408398.2012.680205
   Cai N, 2016, J FUNCT FOODS, V26, P309, DOI 10.1016/j.jff.2016.08.014
   Castellino G, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112580
   Charlton MR, 2011, GASTROENTEROLOGY, V141, P1249, DOI 10.1053/j.gastro.2011.06.061
   Chen GQ, 2018, EXPERT OPIN THER PAT, V28, P415, DOI 10.1080/13543776.2018.1455829
   Chen H, 2012, CIRC J, V76, P995, DOI 10.1253/circj.CJ-11-0344
   Chen JJ, 2009, J NAT PROD, V72, P107, DOI 10.1021/np800689b
   Chen LG, 2008, FOOD CHEM TOXICOL, V46, P688, DOI 10.1016/j.fct.2007.09.096
   Cheng Z, 2022, BIOMED PHARMACOTHER, V146, DOI 10.1016/j.biopha.2021.112491
   Chin YW, 2008, MINI-REV ORG CHEM, V5, P355, DOI 10.2174/157019308786242223
   Choi DH, 2012, J MED FOOD, V15, P169, DOI 10.1089/jmf.2010.1222
   Choi DH, 2012, IMMUNOPHARM IMMUNOT, V34, P4, DOI 10.3109/08923973.2011.569889
   Choi Y., 2013, EVID-BASED COMPL ALT, V2013
   Choi YH, 2015, J AGR FOOD CHEM, V63, P8399, DOI 10.1021/acs.jafc.5b01637
   Chou ST, 2011, ANTICANCER RES, V31, P1667
   Chung CY, 2013, INT J MOL SCI, V14, P22395, DOI 10.3390/ijms141122395
   de Bem GF, 2018, J NUTR BIOCHEM, V52, P70, DOI 10.1016/j.jnutbio.2017.09.021
   de Moura RS, 2012, PHYTOMEDICINE, V19, P262, DOI 10.1016/j.phymed.2011.11.004
   de Oliveira PRB, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0143721
   de Souza MO, 2012, NUTR RES, V32, P976, DOI 10.1016/j.nutres.2012.10.001
   Dong YQ, 2020, THERANOSTICS, V10, P179, DOI 10.7150/thno.36722
   Du ZY, 2013, BBA-MOL CELL BIOL L, V1831, P291, DOI 10.1016/j.bbalip.2012.10.002
   Farombi EO, 2020, FOOD CHEM TOXICOL, V142, DOI [10.1016/j.fri.2020.111483, 10.1016/j.fct.2020.111483]
   Feng WY, 2006, CURR DRUG METAB, V7, P755, DOI 10.2174/138920006778520552
   Fruci B, 2013, INT J MOL SCI, V14, P22933, DOI 10.3390/ijms141122933
   Fujisawa H, 2008, J AGR FOOD CHEM, V56, P4229, DOI 10.1021/jf8000907
   Gai HY, 2020, J FOOD SCI, V85, P4050, DOI 10.1111/1750-3841.15482
   Gu L, 2019, J AGR FOOD CHEM, V67, P13929, DOI 10.1021/acs.jafc.9b05632
   Gu Y, 2012, BLOOD, V120, P4829, DOI 10.1182/blood-2012-06-434894
   Han CY, 2011, ANTIOXID REDOX SIGN, V14, P187, DOI 10.1089/ars.2010.3190
   Hardie DG, 2014, CELL METAB, V20, P939, DOI 10.1016/j.cmet.2014.09.013
   Hashem RM, 2017, BIOMED PHARMACOTHER, V88, P293, DOI 10.1016/j.biopha.2017.01.035
   Hou XY, 2008, J BIOL CHEM, V283, P20015, DOI 10.1074/jbc.M802187200
   Hu SW, 2014, J BIOSCI BIOENG, V117, P457, DOI 10.1016/j.jbiosc.2013.09.005
   Iranshahy M, 2019, EUR J PHARMACOL, V850, P1, DOI 10.1016/j.ejphar.2019.02.004
   Jia L, 2016, SCI REP-UK, V6, DOI 10.1038/srep36209
   Jung UJ, 2011, BBA-MOL CELL BIOL L, V1811, P491, DOI 10.1016/j.bbalip.2011.06.003
   Kajszczak D, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113398
   Kalinkevich K, 2014, RUSS J BIOORG CHEM+, V40, P752, DOI 10.1134/S106816201407005X
   Kang MJ, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00537
   Karamac M, 2017, MOLECULES, V22, DOI 10.3390/molecules22040527
   Kim HJ, 2013, KOREAN J PHYSIOL PHA, V17, P217, DOI 10.4196/kjpp.2013.17.3.217
   Kim MS, 2004, NAT MED, V10, P727, DOI 10.1038/nm1061
   Kim SY, 2010, J MED FOOD, V13, P1069, DOI 10.1089/jmf.2009.1365
   Kim SH, 2015, EXP BIOL MED, V240, P946, DOI 10.1177/1535370214558022
   Kim S, 2020, J NAT MED-TOKYO, V74, P142, DOI 10.1007/s11418-019-01356-x
   Kudo M, 2021, FOOD SCI NUTR, V9, P4893, DOI 10.1002/fsn3.2439
   Kudo M, 2017, BIOL PHARM BULL, V40, P524, DOI 10.1248/bpb.b16-01002
   Kwon EB, 2018, EVID-BASED COMPL ALT, V2018, DOI 10.1155/2018/3140267
   Le Roy T, 2013, GUT, V62, P1787, DOI 10.1136/gutjnl-2012-303816
   Lee HI, 2014, METABOLISM, V63, P593, DOI 10.1016/j.metabol.2014.01.003
   Lee HU, 2005, LIVER INT, V25, P1069, DOI 10.1111/j.1478-3231.2005.01068.x
   Lee JH, 2015, EXP BIOL MED, V240, P508, DOI 10.1177/1535370214547123
   Lee KE, 2017, EXP DERMATOL, V26, P958, DOI 10.1111/exd.13319
   Lee MK, 2000, J PHARM PHARMACOL, V52, P341, DOI 10.1211/0022357001773896
   Lee MK, 2000, J NEUROSCI RES, V59, P259, DOI 10.1002/(SICI)1097-4547(20000115)59:2<259::AID-JNR12>3.0.CO;2-3
   Lee YJ, 2011, PHARMACOL THERAPEUT, V130, P157, DOI 10.1016/j.pharmthera.2011.01.010
   Leung AY, 2006, TOXICOL PATHOL, V34, P319, DOI 10.1080/01926230600773958
   Li CC, 2018, MOL NUTR FOOD RES, V62, DOI 10.1002/mnfr.201700738
   Li DM, 2021, PHYTOTHER RES, V35, P1416, DOI 10.1002/ptr.6902
   Li DM, 2019, J AGR FOOD CHEM, V67, P12208, DOI 10.1021/acs.jafc.9b05495
   Li W, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/196198
   Li XQ, 2016, SCI REP-UK, V6, DOI 10.1038/srep26854
   Li Y, 2011, CELL METAB, V13, P376, DOI 10.1016/j.cmet.2011.03.009
   Li YC, 2018, NUTRIENTS, V10, DOI 10.3390/nu10081024
   Lim L, 2015, J NANOSCI NANOTECHNO, V15, P116, DOI 10.1166/jnn.2015.8382
   Lin JW, 2012, NEURO-ONCOLOGY, V14, P302, DOI 10.1093/neuonc/nor217
   Liu HM, 2018, NUTRIENTS, V10, DOI 10.3390/nu10070830
   Liu XF, 2013, LIPIDS HEALTH DIS, V12, DOI 10.1186/1476-511X-12-109
   Liu YJ, 2017, LIPIDS, V52, P119, DOI 10.1007/s11745-016-4222-1
   Liu YJ, 2015, J FUNCT FOODS, V17, P504, DOI 10.1016/j.jff.2015.06.009
   Liu YZ, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24076285
   Lu J, 2018, LIFE SCI, V209, P324, DOI 10.1016/j.lfs.2018.08.007
   Ma XR, 2015, CELL METAB, V22, P695, DOI 10.1016/j.cmet.2015.08.005
   Ma ZH, 2017, BIOMED PHARMACOTHER, V90, P361, DOI 10.1016/j.biopha.2017.03.087
   Mahdiani S, 2022, BIOFACTORS, V48, P744, DOI 10.1002/biof.1876
   Matheus ME, 2006, J ETHNOPHARMACOL, V107, P291, DOI 10.1016/j.jep.2006.03.010
   Meex RCR, 2021, MOL NUTR FOOD RES, V65, DOI 10.1002/mnfr.201900942
   Mei RQ, 2008, HELV CHIM ACTA, V91, P90, DOI 10.1002/hlca.200890018
   Molaei A, 2022, LIFE SCI, V306, DOI 10.1016/j.lfs.2022.120844
   Moon HI, 2011, HUM EXP TOXICOL, V30, P870, DOI 10.1177/0960327110382131
   MURAMATSU K, 1986, J NUTR SCI VITAMINOL, V32, P613, DOI 10.3177/jnsv.32.613
   Nelson LE, 2012, AM J PHYSIOL-CELL PH, V303, pC4, DOI 10.1152/ajpcell.00296.2011
   Oh SY, 2003, J BIOL CHEM, V278, P28410, DOI 10.1074/jbc.M300553200
   Omidkhoda N, 2023, EUR J DRUG METAB PH, V48, P1, DOI 10.1007/s13318-022-00802-8
   Pan MH, 2014, MOL NUTR FOOD RES, V58, P147, DOI 10.1002/mnfr.201300522
   Pan R, 2009, INT IMMUNOPHARMACOL, V9, P859, DOI 10.1016/j.intimp.2009.02.019
   Park EJ, 2003, PLANTA MED, V69, P33, DOI 10.1055/s-2003-37027
   Park EJ, 2016, EUR J PHARMACOL, V788, P200, DOI 10.1016/j.ejphar.2016.06.040
   Park EY, 2015, MAR DRUGS, V13, P6866, DOI 10.3390/md13116866
   Park HJ, 2020, J ETHNOPHARMACOL, V251, DOI 10.1016/j.jep.2019.112518
   Perova IB, 2014, PHARM CHEM J+, V48, P332, DOI 10.1007/s11094-014-1105-8
   Pietrzyk N, 2021, J FUNCT FOODS, V80, DOI 10.1016/j.jff.2021.104437
   Podsedek A, 2020, J FUNCT FOODS, V73, DOI 10.1016/j.jff.2020.104111
   Quan XF, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033376
   Reygaert WC, 2014, FRONT MICROBIOL, V5, DOI 10.3389/fmicb.2014.00434
   Rimando AM, 2005, J CHROMATOGR A, V1078, P196, DOI 10.1016/j.chroma.2005.05.009
   Rocha A. P. M., 2008, Journal of Pharmacology and Toxicology, V3, P435
   Rollinger JM, 2004, J MED CHEM, V47, P6248, DOI 10.1021/jm049655r
   Rop O, 2010, MOLECULES, V15, P4467, DOI 10.3390/molecules15064467
   Sagdic O, 2006, ACTA ALIMENT HUNG, V35, P487, DOI 10.1556/AAlim.35.2006.4.12
   Santamarina AB, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0141227
   SCHIFF PL, 1991, J NAT PROD, V54, P645, DOI 10.1021/np50075a001
   Seo MS, 2015, TOXICOL APPL PHARM, V284, P113, DOI 10.1016/j.taap.2015.02.020
   Sharma A, 2021, FOOD FUNCT, V12, P892, DOI [10.1039/d0fo02501a, 10.1039/D0FO02501A]
   Sharma A, 2020, EUR J PHARMACOL, V882, DOI 10.1016/j.ejphar.2020.173244
   SHEEN WS, 1994, PHYTOCHEMISTRY, V36, P213, DOI 10.1016/S0031-9422(00)97039-0
   Shimano H, 2001, PROG LIPID RES, V40, P439, DOI 10.1016/S0163-7827(01)00010-8
   Tilg H, 2010, HEPATOLOGY, V52, P1836, DOI 10.1002/hep.24001
   Tsai Y, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.598555
   Wang S, 2009, MOL CANCER, V8, DOI 10.1186/1476-4598-8-81
   Wang XX, 2013, MAR BIOTECHNOL, V15, P197, DOI 10.1007/s10126-012-9477-9
   Wu SS, 2017, MOL NUTR FOOD RES, V61, DOI [10.1002/mnfr.201600858, 10.1002/mnfr.201770044]
   Xiao J, 2013, NUTR DIABETES, V3, DOI 10.1038/nutd.2013.22
   Xiao J, 2014, SCI REP-UK, V4, DOI 10.1038/srep05587
   Xiao J, 2014, EUR J NUTR, V53, P187, DOI 10.1007/s00394-013-0516-8
   Xu Chao-qian, 2004, Yaoxue Xuebao, V39, P691
   Xu J, 2011, BIOSCI BIOTECH BIOCH, V75, P1466, DOI 10.1271/bbb.110126
   Xu YF, 2017, CELL SIGNAL, V29, P209, DOI 10.1016/j.cellsig.2016.11.001
   Yang F, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0094443
   Yang J, 2016, PHYTOMEDICINE, V23, P181, DOI 10.1016/j.phymed.2015.12.018
   Yang SB, 2014, BIOL PHARM BULL, V37, P1390, DOI 10.1248/bpb.b13-00939
   Yin HQ, 2009, TOXICOL APPL PHARM, V236, P124, DOI 10.1016/j.taap.2008.12.030
   Yin Y, 2017, BIOCHEM BIOPH RES CO, V482, P720, DOI 10.1016/j.bbrc.2016.11.101
   Yoo A, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-02416-6
   Yoon SH, 2007, BIOL PHARM BULL, V30, P2196, DOI 10.1248/bpb.30.2196
   Yousefian M, 2019, PHYTOMEDICINE, V55, P200, DOI 10.1016/j.phymed.2018.08.002
   Zahoor A, 2020, PHYTOMEDICINE, V76, DOI 10.1016/j.phymed.2020.153248
   Zaklos-Szyda M, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21144909
   Zaklos-Szyda M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12072003
   Zaklos-Szyda M, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9050433
   Zaklos-Szyda M, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8080262
   Zeng ZH, 2017, EXP CLIN ENDOCR DIAB, V125, P610, DOI 10.1055/s-0043-101919
   Zhang JX, 2020, AM J CHINESE MED, V48, P579, DOI 10.1142/S0192415X20500299
   Zhang JJ, 2022, FOOD FUNCT, V13, P1153, DOI [10.1039/D1FO03026D, 10.1039/d1fo03026d]
   Zhang LJ, 2015, BIOL PHARM BULL, V38, P1005, DOI 10.1248/bpb.b14-00892
   Zhang TS, 2014, FOOD FUNCT, V5, P1134, DOI 10.1039/c3fo60694e
   Zhang YL, 2017, MOL METAB, V6, P138, DOI 10.1016/j.molmet.2016.11.002
   Zhang Y, 2022, FOOD FUNCT, V13, P2295, DOI [10.1039/d1fo04147a, 10.1039/D1FO04147A]
   Zhang Y, 2017, J FUNCT FOODS, V29, P217, DOI 10.1016/j.jff.2016.12.030
   Zhu YX, 2020, LIFE SCI, V256, DOI 10.1016/j.lfs.2020.117990
NR 159
TC 6
Z9 6
U1 9
U2 30
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD DEC
PY 2023
VL 37
IS 12
BP 5769
EP 5786
DI 10.1002/ptr.8020
EA SEP 2023
PG 18
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GJ8D9
UT WOS:001071311800001
PM 37748097
DA 2025-06-11
ER

PT J
AU Sato, A
   Shiraishi, Y
   Kimura, T
   Osaki, A
   Kagami, K
   Ido, Y
   Adachi, T
AF Sato, Atsushi
   Shiraishi, Yasunaga
   Kimura, Toyokazu
   Osaki, Ayumu
   Kagami, Kazuki
   Ido, Yasuo
   Adachi, Takeshi
TI Resistance to Obesity in SOD1 Deficient Mice with a
   High-Fat/High-Sucrose Diet
SO ANTIOXIDANTS
LA English
DT Article
DE SOD1; metabolic syndrome; superoxide anion; ATP; mitochondrial
   intermembrane space; insulin secretion; AMPK; oxygen consumption
ID ACTIVATED PROTEIN-KINASE; INSULIN-RESISTANCE; OXYGEN-CONSUMPTION;
   HYDROGEN-PEROXIDE; AMPK ACTIVATION; SUPEROXIDE; RADICALS; STRESS;
   MECHANISMS; SECRETION
AB Metabolic syndrome (Mets) is an important condition because it may cause stroke and heart disease in the future. Reactive oxygen species (ROSs) influence the pathogenesis of Mets; however, the types of ROSs and their localization remain largely unknown. In this study, we investigated the effects of SOD1, which localize to the cytoplasm and mitochondrial intermembrane space and metabolize superoxide anion, on Mets using SOD1 deficient mice (SOD1(-/-)). SOD1(-/-) fed on a high-fat/high-sucrose diet (HFHSD) for 24 weeks showed reduced body weight gain and adipose tissue size compared to wild-type mice (WT). Insulin secretion was dramatically decreased in SOD1(-/-) fed on HFHSD even though blood glucose levels were similar to WT. Ambulatory oxygen consumption was accelerated in SOD1(-/-) with HFHSD; however, ATP levels of skeletal muscle were somewhat reduced compared to WT. Reflecting the reduced ATP, the expression of phosphorylated AMPK (Thr 172) was more robust in SOD1(-/-). SOD1 is involved in the ATP production mechanism in mitochondria and may contribute to visceral fat accumulation by causing insulin secretion and insulin resistance.
C1 [Sato, Atsushi; Kimura, Toyokazu; Osaki, Ayumu; Kagami, Kazuki; Ido, Yasuo; Adachi, Takeshi] Natl Def Med Coll, Dept Internal Med, Div Cardiovasc Med, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan.
   [Shiraishi, Yasunaga] Natl Def Med Coll, Div Environm Med, Res Inst, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan.
C3 National Defense Medical College - Japan; National Defense Medical
   College - Japan
RP Adachi, T (corresponding author), Natl Def Med Coll, Dept Internal Med, Div Cardiovasc Med, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan.
EM atsushi19821005@yahoo.co.jp; sirayasu10@hotmail.com;
   oyotikuuyakim@gmail.com; ayumu.osaki@gmail.com; mirror.1028k@gmail.com;
   yasaoido@me.com; tadachibu@gmail.com
OI sato, atsushi/0000-0002-2138-3173; Shiraishi,
   Yasunaga/0000-0001-5901-4026; Kimura, Toyokazu/0000-0002-1347-5115
FU Ministry of Defense; Research Fund of the Mitsukoshi Health andWelfare
   Foundation; JSPS KAKENHI [JP 18H02815, JP20K17204]
FX This work was supported in part by a grant from the Ministry of Defense
   and the Research Fund of the Mitsukoshi Health andWelfare Foundation and
   by the JSPS KAKENHI Grant Number JP 18H02815 and JP20K17204.
CR Ando K, 2009, FREE RADICAL BIO MED, V47, P213, DOI 10.1016/j.freeradbiomed.2009.04.030
   Auberval N, 2014, DIABETOL METAB SYNDR, V6, DOI 10.1186/1758-5996-6-130
   Barnes K, 2002, J CELL SCI, V115, P2433
   Bloch-Damti A, 2005, ANTIOXID REDOX SIGN, V7, P1553, DOI 10.1089/ars.2005.7.1553
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Brown JD, 2012, J APPL PHYSIOL, V113, P473, DOI 10.1152/japplphysiol.00668.2011
   Brunmair B, 2004, DIABETES, V53, P1052, DOI 10.2337/diabetes.53.4.1052
   Butler AE, 2013, DIABETES, V62, P2595, DOI 10.2337/db12-1686
   CADENAS E, 1977, ARCH BIOCHEM BIOPHYS, V180, P248, DOI 10.1016/0003-9861(77)90035-2
   CROSS CE, 1987, ANN INTERN MED, V107, P526, DOI 10.7326/0003-4819-107-4-526
   Deepa SS, 2019, FREE RADICAL BIO MED, V132, P19, DOI 10.1016/j.freeradbiomed.2018.06.032
   Echtay KS, 2002, NATURE, V415, P96, DOI 10.1038/415096a
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Finkel T, 1998, CURR OPIN CELL BIOL, V10, P248, DOI 10.1016/S0955-0674(98)80147-6
   Frikke-Schmidt H, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076060
   Fukai T, 2011, ANTIOXID REDOX SIGN, V15, P1583, DOI 10.1089/ars.2011.3999
   HALL JC, 1954, AM J PHYSIOL, V179, P29, DOI 10.1152/ajplegacy.1954.179.1.29
   Hardie DG, 2011, GENE DEV, V25, P1895, DOI 10.1101/gad.17420111
   Hinchy EC, 2018, J BIOL CHEM, V293, P17208, DOI 10.1074/jbc.RA118.002579
   Huang SH, 2007, CELL METAB, V5, P237, DOI 10.1016/j.cmet.2007.03.006
   Ishigami N, 2011, J ATHEROSCLER THROMB, V18, P1009
   Kaludercic N, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/3869610
   Kennedy AJ, 2010, DIS MODEL MECH, V3, P156, DOI 10.1242/dmm.003467
   Krauss S, 2003, J CLIN INVEST, V112, P1831, DOI 10.1172/JCI200319774
   Kujiraoka T, 2013, J AM HEART ASSOC, V2, DOI 10.1161/JAHA.113.000361
   Mahjoub S, 2012, CASP J INTERN MED, V3, P386
   Marvyn PM, 2016, DATA BRIEF, V7, P472, DOI 10.1016/j.dib.2016.02.066
   Morgan BJ, 2011, RECENT PATENTS ENDOC, V5, P25, DOI 10.2174/187221411794351914
   Muller FL, 2004, J BIOL CHEM, V279, P49064, DOI 10.1074/jbc.M407715200
   Reaven G, 2004, ENDOCRIN METAB CLIN, V33, P283, DOI 10.1016/j.ecl.2004.03.002
   Ruderman NB, 2013, J CLIN INVEST, V123, P2764, DOI 10.1172/JCI67227
   Russell-Jones D, 2007, DIABETES OBES METAB, V9, P799, DOI 10.1111/j.1463-1326.2006.00686.x
   Sagi H, 2020, EXP GERONTOL, V130, DOI 10.1016/j.exger.2019.110795
   Saisho Y, 2011, DIABETES, V60, P848, DOI 10.2337/db09-1368
   Sakai K, 2003, BIOCHEM BIOPH RES CO, V300, P216, DOI 10.1016/S0006-291X(02)02832-2
   Shao D, 2014, CELL METAB, V19, P232, DOI 10.1016/j.cmet.2013.12.013
   Shiraishi Y, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10030471
   Takaguri A, 2016, CELL BIOL INT, V40, P1204, DOI 10.1002/cbin.10673
   Taniguchi CM, 2006, NAT REV MOL CELL BIO, V7, P85, DOI 10.1038/nrm1837
   Teratani T, 2020, FREE RADICAL BIO MED, V156, P45, DOI 10.1016/j.freeradbiomed.2020.06.005
   TURRENS JF, 1980, BIOCHEM J, V191, P421, DOI 10.1042/bj1910421
   Vincent HK, 2006, INT J OBESITY, V30, P400, DOI 10.1038/sj.ijo.0803177
   Winder WW, 1996, AM J PHYSIOL-ENDOC M, V270, pE299, DOI 10.1152/ajpendo.1996.270.2.E299
   Wong SK, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0123-9
   Yu LP, 2014, J BIOENERG BIOMEMBR, V46, P33, DOI 10.1007/s10863-013-9530-z
   Zhang CY, 2001, CELL, V105, P745, DOI 10.1016/S0092-8674(01)00378-6
   Zmijewski JW, 2010, J BIOL CHEM, V285, P33154, DOI 10.1074/jbc.M110.143685
NR 47
TC 4
Z9 4
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUL
PY 2022
VL 11
IS 7
AR 1403
DI 10.3390/antiox11071403
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 3J2PI
UT WOS:000833242000001
PM 35883894
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Asadipooya, K
   Lankarani, KB
   Raj, R
   Kalantarhormozi, M
AF Asadipooya, Kamyar
   Lankarani, Kamran B.
   Raj, Rishi
   Kalantarhormozi, Mohammadreza
TI RAGE is a Potential Cause of Onset and Progression of Nonalcoholic Fatty
   Liver Disease
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Review
ID GLYCATION END-PRODUCTS; SOLUBLE RECEPTOR; OXIDATIVE STRESS;
   HEPATOCELLULAR-CARCINOMA; DIABETIC-RETINOPATHY; GENE POLYMORPHISMS;
   INSULIN-RESISTANCE; RISK-FACTORS; SERUM-LEVELS; SRAGE
AB Objective. Fatty liver is a rising global health concern, significantly increasing the burden of health care cost. Nonalcoholic fatty liver disease (NAFLD) has a correlation with metabolic syndrome and its complications. Method. We reviewed the literature regarding the mechanisms of developing NAFLD through AGE-RAGE signaling. Results. NAFLD, metabolic syndrome, and production of advanced glycation end-products (AGEs) share many common risk factors and appear to be connected. AGE induces production of the receptor for AGE (RAGE). AGE-RAGE interaction contributes to fat accumulation in the liver leading to inflammation, fibrosis, insulin resistance, and other complications of the fatty liver disease. The immune system, especially macrophages, has an important defense mechanism against RAGE pathway activities. Conclusion. Soluble form of RAGE (sRAGE) has the capability to reduce inflammation by blocking the interaction of AGE with RAGE. However, sRAGE has some limitations, and the best method of usage is probably autotransplantation of transfected stem cells or monocytes, as a precursor of macrophages and Kupffer cells, with a virus that carries sRAGE to alleviate the harmful effects of AGE-RAGE signaling in the settings of fatty liver disease.
C1 [Asadipooya, Kamyar] Univ Kentucky, Dept Med, Div Endocrinol & Mol Med, Lexington, KY 40506 USA.
   [Lankarani, Kamran B.] Shiraz Univ Med Sci, Inst Hlth, Hlth Policy Res Ctr, Shiraz, Iran.
   [Raj, Rishi] Univ Kentucky, Dept Med, Div Endocrinol & Mol Med, Lexington, KY 40506 USA.
   [Kalantarhormozi, Mohammadreza] Bushehr Univ Med Sci, Persian Gulf Trop Med Res Ctr, Endocrinol & Internal Med, Bushehr, Iran.
C3 University of Kentucky; Shiraz University of Medical Science; University
   of Kentucky
RP Asadipooya, K (corresponding author), Univ Kentucky, Dept Med, Div Endocrinol & Mol Med, Lexington, KY 40506 USA.
EM kas224@uky.edu
RI lankarani, kamran/D-5901-2012; Asadipooya, Kamyar/AAF-5660-2020;
   KalantarHormozi, MohammadReza/A-4427-2018; Bagheri Lankarani,
   Kamran/P-2066-2017; Raj, Rishi/Q-2409-2018
OI Kalantarhormozi, Mohammadreza/0000-0003-4029-2370; Asadipooya,
   Kamyar/0000-0003-4484-1971; Bagheri Lankarani,
   Kamran/0000-0002-7524-9017; Raj, Rishi/0000-0002-4151-3246
CR Adams LA, 2005, J HEPATOL, V42, P132, DOI 10.1016/j.jhep.2004.09.012
   Anstee QM, 2019, NAT REV GASTRO HEPAT, V16, P411, DOI 10.1038/s41575-019-0145-7
   Antonucci L, 2017, NUTRIENTS, V9, DOI 10.3390/nu9101137
   Aragno M, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040385
   Asadipooya K, 2019, J ENDOCR SOC, V3, P1799, DOI 10.1210/js.2019-00160
   Asadipooya K, 2019, J CLIN ENDOCR METAB, V104, P682, DOI 10.1210/jc.2018-02066
   Bedossa P, 2017, LIVER INT, V37, P85, DOI 10.1111/liv.13301
   Bellentani S, 2017, LIVER INT, V37, P81, DOI 10.1111/liv.13299
   Biswas SK, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/150325
   Brix JM, 2012, INT J OBESITY, V36, P1412, DOI 10.1038/ijo.2012.107
   Browning JD, 2004, AM J GASTROENTEROL, V99, P292, DOI 10.1111/j.1572-0241.2004.04059.x
   Brunt EM, 2017, GUT, V66, P1539, DOI 10.1136/gutjnl-2016-313379
   Brusotti G, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-05666-6
   Byun K, 2017, PHARMACOL THERAPEUT, V177, P44, DOI 10.1016/j.pharmthera.2017.02.030
   Cai W, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/310237
   Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI 10.1002/hep.29367
   Corey KE, 2017, WORLD J HEPATOL, V9, P385, DOI 10.4254/wjh.v9.i7.385
   D'Adamo E, 2013, FREE RADICAL RES, V47, P146, DOI 10.3109/10715762.2012.755262
   D'Adamo E, 2011, ANTIOXID REDOX SIGN, V14, P1167, DOI 10.1089/ars.2010.3719
   Nguyen DV, 2017, PHARMACOL THERAPEUT, V180, P139, DOI 10.1016/j.pharmthera.2017.06.012
   DiNicolantonio JJ, 2018, PROG CARDIOVASC DIS, V61, P3, DOI 10.1016/j.pcad.2017.12.001
   Dongiovanni P, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18071534
   EASL, 2016, OBESITY FACTS, V9, P65, DOI [10.1159/000443344, 10.1007/s00125-016-3902-y, 10.1016/j.jhep.2015.11.004]
   Engin A, 2017, ADV EXP MED BIOL, V960, P443, DOI 10.1007/978-3-319-48382-5_19
   Eshraghian A, 2017, WORLD J GASTROENTERO, V23, P7495, DOI 10.3748/wjg.v23.i42.7495
   Gaens KHJ, 2012, J HEPATOL, V56, P647, DOI 10.1016/j.jhep.2011.07.028
   Goudarzi M, 2018, HUM EXP TOXICOL, V37, P532, DOI 10.1177/0960327117715900
   Harmon DB, 2018, AM J PHYSIOL-ENDOC M, V315, pE758, DOI 10.1152/ajpendo.00172.2018
   Hassan RH, 2014, WORLD J DIABETES, V5, P244, DOI 10.4239/wjd.v5.i3.244
   He M, 2011, EMBO REP, V12, P358, DOI 10.1038/embor.2011.28
   Hernaez R, 2011, HEPATOLOGY, V54, P1082, DOI 10.1002/hep.24452
   Honarvar B, 2017, HEPAT MON, V17, DOI 10.5812/hepatmon.44962
   Hudson BI, 2008, J BIOL CHEM, V283, P34457, DOI 10.1074/jbc.M801465200
   Hyogo H, 2007, J GASTROEN HEPATOL, V22, P1112, DOI 10.1111/j.1440-1746.2007.04943.x
   Kan H, 2015, J CLIN LAB ANAL, V29, P480, DOI 10.1002/jcla.21797
   Kang PP, 2012, GENE, V500, P1, DOI 10.1016/j.gene.2012.03.056
   Kawai T, 2010, NAT IMMUNOL, V11, P373, DOI 10.1038/ni.1863
   Kierdorf K, 2013, J LEUKOCYTE BIOL, V94, P55, DOI 10.1189/jlb.1012519
   Kimura Y, 2010, J GASTROENTEROL, V45, P750, DOI 10.1007/s00535-010-0203-y
   Ku SH, 2015, ARCH PHARM RES, V38, P1317, DOI 10.1007/s12272-014-0527-x
   Lankarani KB, 2013, HEPAT MON, V13, DOI 10.5812/hepatmon.9248
   Leclercq IA, 2007, J HEPATOL, V47, P142, DOI 10.1016/j.jhep.2007.04.002
   Leung C, 2016, WORLD J GASTROENTERO, V22, P8026, DOI 10.3748/wjg.v22.i35.8026
   Li J, 2016, J INT MED RES, V44, P520, DOI 10.1177/0300060516638990
   Li PC, 2017, MOL MED REP, V16, P3421, DOI 10.3892/mmr.2017.6978
   Li W, 2016, BIOMED REP, V4, P691, DOI 10.3892/br.2016.641
   Lin YN, 2016, BIOCHEM SOC T, V44, P1289, DOI 10.1042/BST20160120
   Litwinoff EMS, 2015, CLIN PHARMACOL THER, V98, P135, DOI 10.1002/cpt.148
   Liu JQ, 2016, APPL BIOCHEM BIOTECH, V178, P1015, DOI 10.1007/s12010-015-1925-3
   Loomba R, 2017, CELL METAB, V25, P1054, DOI 10.1016/j.cmet.2017.04.001
   López-Díez R, 2016, BBA-MOL BASIS DIS, V1862, P2244, DOI 10.1016/j.bbadis.2016.05.005
   Manigrasso MB, 2016, SCI REP-UK, V6, DOI 10.1038/srep22450
   Marra F, 2018, J HEPATOL, V68, P280, DOI 10.1016/j.jhep.2017.11.014
   Matsui T, 2017, DIABETES, V66, P1683, DOI 10.2337/db16-1281
   Mehta R, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0199294
   Mendez-Sanchez N, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19072034
   Moghaddasifar I, 2016, INT J TRANSPLANT MED, V7, P149
   Muellenbach EA, 2008, METABOLISM, V57, P1465, DOI 10.1016/j.metabol.2008.05.018
   Musumeci D, 2014, PHARMACOL THERAPEUT, V141, P347, DOI 10.1016/j.pharmthera.2013.11.001
   Norata GD, 2009, NUTR METAB CARDIOVAS, V19, P129, DOI 10.1016/j.numecd.2008.03.004
   Ott C, 2014, REDOX BIOL, V2, P411, DOI 10.1016/j.redox.2013.12.016
   Palma-Duran SA, 2018, METABOLISM, V83, P120, DOI 10.1016/j.metabol.2018.01.023
   Pasupulati Anil Kumar, 2016, BioMolecular Concepts, V7, P293, DOI 10.1515/bmc-2016-0021
   Patel R, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035143
   Petrovic A, 2017, J PHYSIOL BIOCHEM, V73, P511, DOI 10.1007/s13105-017-0574-0
   Petta S, 2017, HEPATOLOGY, V65, P1145, DOI 10.1002/hep.28843
   Ratziu V, 2003, J HEPATOL, V39, P1049, DOI 10.1016/S0168-8278(03)00456-2
   Reccia I, 2017, METABOLISM, V72, P94, DOI 10.1016/j.metabol.2017.04.011
   Samuel VT, 2018, CELL METAB, V27, P22, DOI 10.1016/j.cmet.2017.08.002
   Santilli F, 2015, VASC PHARMACOL, V72, P16, DOI 10.1016/j.vph.2015.04.004
   Schmidt AM, 2017, ARTERIOSCL THROM VAS, V37, P613, DOI 10.1161/ATVBAHA.117.307263
   Schwimmer JB, 2017, HEPATOLOGY, V66, p1117A
   Serban AI, 2015, J DIABETES, V7, P114, DOI 10.1111/1753-0407.12154
   Sharma M, 2015, J CLIN EXP HEPATOL, V5, P147, DOI 10.1016/j.jceh.2015.02.002
   Son M, 2017, BRAIN BEHAV IMMUN, V66, P347, DOI 10.1016/j.bbi.2017.07.158
   Song F, 2014, DIABETES, V63, P1948, DOI 10.2337/db13-1636
   Sookoian S, 2017, ALIMENT PHARM THER, V46, P85, DOI 10.1111/apt.14112
   Su SC, 2015, MEDICINE, V94, DOI 10.1097/MD.0000000000001396
   Su XD, 2011, ARCH MED RES, V42, P596, DOI 10.1016/j.arcmed.2011.11.001
   Takeuchi M, 2017, NUTRIENTS, V9, DOI 10.3390/nu9060634
   Tan KCB, 2007, DIABETOLOGIA, V50, P1819, DOI 10.1007/s00125-007-0759-0
   Targher G, 2017, NAT REV NEPHROL, V13, P297, DOI 10.1038/nrneph.2017.16
   Tsai E, 2018, CLIN LIVER DIS, V22, P73, DOI 10.1016/j.cld.2017.08.004
   Unoki H, 2008, CURR PHARM DESIGN, V14, P987, DOI 10.2174/138161208784139747
   Viganò L, 2018, HEPATOBIL SURG NUTR, V7, P130, DOI 10.21037/hbsn.2018.01.01
   Vilar-Gomez E, 2018, J HEPATOL, V68, P305, DOI 10.1016/j.jhep.2017.11.013
   Wang J, 2015, INT J CLIN EXP PATHO, V8, P12028
   Wang Q, 2017, J DIABETES RES, V2017, DOI 10.1155/2017/1428537
   Wei XC, 2016, NATURE, V539, P294, DOI 10.1038/nature20117
   Wu Q, 2016, APOPTOSIS, V21, P36, DOI 10.1007/s10495-015-1191-4
   Xu L, 2016, LIPIDS HEALTH DIS, V15, DOI 10.1186/s12944-016-0334-0
   Yilmaz Y, 2009, CLIN BIOCHEM, V42, P802, DOI 10.1016/j.clinbiochem.2009.02.003
   Zelber-Sagi S, 2017, DIGEST LIVER DIS, V49, P523, DOI 10.1016/j.dld.2017.01.148
   Zeng S, 2004, HEPATOLOGY, V39, P422, DOI 10.1002/hep.20045
   Zhou ZE, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/4847812
   Zhuang AW, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-12548-4
NR 96
TC 38
Z9 38
U1 2
U2 32
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PD SEP 18
PY 2019
VL 2019
AR 2151302
DI 10.1155/2019/2151302
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JB3RP
UT WOS:000488474700001
PM 31641351
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Van Laecke, S
   Van Biesen, W
   Vanholder, R
AF Van Laecke, S.
   Van Biesen, W.
   Vanholder, R.
TI The paradox of bardoxolone methyl: a call for every witness on the
   stand?
SO DIABETES OBESITY & METABOLISM
LA English
DT Review
DE bardoxolone methyl; cardiovascular; diabetes; magnesium
ID CHRONIC KIDNEY-DISEASE; CORONARY-ARTERY-DISEASE; ORAL MAGNESIUM THERAPY;
   HEART-FAILURE; CARDIOVASCULAR MORTALITY; ENDOTHELIAL DYSFUNCTION;
   DIABETIC-NEPHROPATHY; METABOLIC SYNDROME; DIETARY MAGNESIUM; ELDERLY
   SUBJECTS
AB Peoplewith type 2 diabetes and chronic kidney disease (CKD) remain an extremely vulnerable population with increased cardiovascular morbidity, mortality and mounting societal costs. As such, any effort to improve their dismal outcome is heavily supported. Yet, most drugs fail to replicate the promising signals of early experiments in humans in large and methodologically sound trials. As a recent example, an independent data and safety committee advised the termination of a phase 3 trial due to excessive cardiovascular disease and especially heart failure in patients allocated to the antioxidant synthetic triterpenoid bardoxolone methyl versus placebo. We evaluate the reasons why this outcome in hindsight was possibly not totally unexpected and develop a mechanistic model that shows that the consistent drop in serum magnesium concentration in patients exposed to bardoxolone methyl might have contributed to the development of heart failure. As such, this trial, despite its negative outcome, might provide additional pieces of the puzzle enabling us to get a better grip on diseases that share increased inflammation and oxidative stress, such as type 2 diabetes, metabolic syndrome, heart failure and CKD.
C1 [Van Laecke, S.; Van Biesen, W.; Vanholder, R.] Ghent Univ Hosp, Div Renal, B-9000 Ghent, Belgium.
C3 Ghent University; Ghent University Hospital
RP Van Laecke, S (corresponding author), Ghent Univ Hosp, Div Renal, De Pintelaan 185, B-9000 Ghent, Belgium.
EM steven.vanlaecke@ugent.be
OI Van Laecke, Steven/0000-0001-7628-8491
FU Astellas
FX S. V. L. wrote the manuscript, and S. V. L., W. V. B. and R. V. H.
   revised the manuscript. S. V. L. has received lecture honoraria from
   Fresenius and has received grants for clinical research from Astellas.
   He does not have any stocks in any pharmaceutical or device company. W.
   V. B. and R. V. H. have no conflicts of interest to disclose.
CR Adamopoulos C, 2009, INT J CARDIOL, V136, P270, DOI 10.1016/j.ijcard.2008.05.006
   Almoznino-Sarafian D, 2007, EUR J NUTR, V46, P230, DOI 10.1007/s00394-007-0655-x
   [Anonymous], 2013, BMJ
   Bahrami H, 2008, J AM COLL CARDIOL, V51, P1775, DOI 10.1016/j.jacc.2007.12.048
   Barbagallo M, 2010, MAGNESIUM RES, V23, P131, DOI 10.1684/mrh.2010.0214
   Borkowski BJ, 2011, EUR HEART J, V32, P1846, DOI 10.1093/eurheartj/ehr063
   Chacko SA, 2010, DIABETES CARE, V33, P304, DOI 10.2337/dc09-1402
   Chin M, 2013, AM J PHYSIOL-RENAL, V304, pF1438, DOI 10.1152/ajprenal.00387.2012
   Chin MP, 2014, AM J NEPHROL, V39, P499, DOI 10.1159/000362906
   Corica F, 2006, J AM COLL NUTR, V25, P210, DOI 10.1080/07315724.2006.10719534
   de Zeeuw D, 2013, NEW ENGL J MED, V369, P2492, DOI 10.1056/NEJMoa1306033
   Del Gobbo LC, 2013, AM J CLIN NUTR, V98, P160, DOI 10.3945/ajcn.112.053132
   Ellison DH, 2014, NEW ENGL J MED, V370, P1768, DOI 10.1056/NEJMc1400872
   Glezeva N, 2013, HEART FAIL REV, DOI [10.1007/s107411-013-9405-8, DOI 10.1007/S107411-013-9405-8]
   HEGGTVEIT HA, 1964, AM J PATHOL, V45, P757
   Hong DS, 2012, CLIN CANCER RES, V18, P3396, DOI 10.1158/1078-0432.CCR-11-2703
   Jun M, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD008176.pub2
   Maier JAM, 2012, CLIN SCI, V122, P397, DOI 10.1042/CS20110506
   Mann JFE, 2010, J AM SOC NEPHROL, V21, P527, DOI 10.1681/ASN.2009060593
   Meyers KEC, 2013, PEDIATR NEPHROL, V28, P711, DOI 10.1007/s00467-012-2316-4
   Paulus WJ, 2013, J AM COLL CARDIOL, V62, P263, DOI 10.1016/j.jacc.2013.02.092
   Pergola PE, 2011, NEW ENGL J MED, V365, P327, DOI 10.1056/NEJMoa1105351
   Pergola PE, 2011, AM J NEPHROL, V33, P469, DOI 10.1159/000327599
   Peters KE, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0074355
   Pokan R, 2006, BRIT J SPORT MED, V40, P773, DOI 10.1136/bjsm.2006.027250
   Reffelmann T, 2010, ATHEROSCLEROSIS, V213, P563, DOI 10.1016/j.atherosclerosis.2010.08.073
   Reisman SA, 2012, J AM SOC NEPHROL, V23, P1663, DOI 10.1681/ASN.2012050457
   Ruiz S, 2013, KIDNEY INT, V83, P1029, DOI 10.1038/ki.2012.439
   Sajadieh A, 2004, EUR HEART J, V25, P363, DOI 10.1016/j.ehj.2003.12.003
   Sakaguchi Y, 2014, KIDNEY INT, V85, P174, DOI 10.1038/ki.2013.327
   Shechter M, 2000, CIRCULATION, V102, P2353, DOI 10.1161/01.CIR.102.19.2353
   Shechter M, 2010, MAGNESIUM RES, V23, P60, DOI 10.1684/mrh.2010.0202
   Siddiqi FS, 2013, DIABETES, V62, P3647, DOI 10.2337/db13-0795
   Sonmez A, 2010, CLIN J AM SOC NEPHRO, V5, P45, DOI 10.2215/CJN.05080709
   Stehouwer CDA, 2008, DIABETOLOGIA, V51, P527, DOI 10.1007/s00125-007-0918-3
   Stepura OB, 2009, INT J CARDIOL, V131, P293, DOI 10.1016/j.ijcard.2007.11.022
   Sverrisdóttir YB, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009257
   Van Laecke S, 2013, AM J MED, V126, P825, DOI 10.1016/j.amjmed.2013.02.036
   Van Laecke S, 2012, NEPHROL DIAL TRANSPL, V27, P4003, DOI 10.1093/ndt/gfs126
   Van Laecke S, 2011, NEW ENGL J MED, V365, P1745, DOI 10.1056/NEJMc1110239
   Vasan RS, 2003, CIRCULATION, V107, P1486, DOI 10.1161/01.CIR.0000057810.48709.F6
   Xu JL, 2012, DIABETES, V61, P3208, DOI 10.2337/db11-1716
   Yu HK, 2013, CLIN CANCER RES, V19, P5340, DOI 10.1158/1078-0432.CCR-12-3685
   Zoja C, 2013, AM J PHYSIOL-RENAL, V304, pF808, DOI 10.1152/ajprenal.00376.2012
NR 44
TC 18
Z9 19
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD JAN
PY 2015
VL 17
IS 1
BP 9
EP 14
DI 10.1111/dom.12356
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CA4BD
UT WOS:000348848300003
PM 25041694
DA 2025-06-11
ER

PT J
AU Li, Z
   Zhou, EC
   Liu, C
   Wicks, H
   Yildiz, S
   Razack, F
   Ying, ZX
   Kooijman, S
   Koonen, DPY
   Heijink, M
   Kostidis, S
   Giera, M
   Sanders, IMJG
   Kuijper, EJ
   Smits, WK
   van Dijk, KW
   Rensen, PCN
   Wang, YA
AF Li, Zhuang
   Zhou, Enchen
   Liu, Cong
   Wicks, Hope
   Yildiz, Sena
   Razack, Farhana
   Ying, Zhixiong
   Kooijman, Sander
   Koonen, Debby P. Y.
   Heijink, Marieke
   Kostidis, Sarantos
   Giera, Martin
   Sanders, Ingrid M. J. G.
   Kuijper, Ed J.
   Smits, Wiep Klaas
   van Dijk, Ko Willems
   Rensen, Patrick C. N.
   Wang, Yanan
TI Dietary butyrate ameliorates metabolic health associated with selective
   proliferation of gut Lachnospiraceae bacterium 28-4
SO JCI INSIGHT
LA English
DT Article
ID CHAIN FATTY-ACIDS; BROWN ADIPOSE-TISSUE; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; MICROBIOTA; RECEPTOR; GLUCOSE; MODEL; MICE
AB Short-chain fatty acids, including butyrate, have multiple metabolic benefits in individuals who are lean but not in individuals with metabolic syndrome, with the underlying mechanisms still being unclear. We aimed to investigate the role of gut microbiota in the induction of metabolic benefits of dietary butyrate. We performed antibiotic-induced microbiota depletion of the gut and fecal microbiota transplantation (FMT) in APOE*3-Leiden.CETP mice, a well-established translational model for developing human-like metabolic syndrome, and revealed that dietary butyrate reduced appetite and ameliorated high-fat diet-induced (HFD-induced) weight gain dependent on the presence of gut microbiota. FMT from butyrate-treated lean donor mice, but not butyrate-treated obese donor mice, into gut microbiota-depleted recipient mice reduced food intake, attenuated HFD-induced weight gain, and improved insulin resistance. 16S rRNA and metagenomic sequencing on cecal bacterial DNA of recipient mice implied that these effects were accompanied by the selective proliferation of Lachnospiraceae bacterium 28-4 in the gut as induced by butyrate. Collectively, our findings reveal a crucial role of gut microbiota in the beneficial metabolic effects of dietary butyrate as strongly associated with the abundance of Lachnospiraceae bacterium 28-4.
C1 [Li, Zhuang; Zhou, Enchen; Liu, Cong; Wicks, Hope; Yildiz, Sena; Razack, Farhana; Ying, Zhixiong; Kooijman, Sander; van Dijk, Ko Willems; Rensen, Patrick C. N.; Wang, Yanan] Leiden Univ, Dept Med, Div Endocrinol, Med Ctr, Leiden, Netherlands.
   [Li, Zhuang; Zhou, Enchen; Liu, Cong; Wicks, Hope; Yildiz, Sena; Razack, Farhana; Ying, Zhixiong; Kooijman, Sander; Rensen, Patrick C. N.; Wang, Yanan] Leiden Univ, Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands.
   [Li, Zhuang] Southern Med Univ, Zhujiang Hosp, Microbiome Med Ctr, Dept Lab Med, Guangzhou, Peoples R China.
   [Koonen, Debby P. Y.] Univ Med Ctr Groningen, Dept Pediat, Groningen, Netherlands.
   [Heijink, Marieke; Kostidis, Sarantos; Giera, Martin] Leiden Univ, Med Ctr, Ctr Prote & Metabol, Leiden, Netherlands.
   [Sanders, Ingrid M. J. G.; Kuijper, Ed J.; Smits, Wiep Klaas] Leiden Univ, Med Ctr, Dept Med Microbiol, Leiden, Netherlands.
   [Kuijper, Ed J.; Smits, Wiep Klaas] Leiden Univ, Med Ctr, Ctr Microbiome Anal & Therapeut, Leiden, Netherlands.
   [van Dijk, Ko Willems] Leiden Univ, Dept Human Genet, Med Ctr, Leiden, Netherlands.
   [Rensen, Patrick C. N.; Wang, Yanan] Xi An Jiao Tong Univ, Affiliated Hosp 1, Med X Inst, Ctr Immunol & Metab Dis, Xian, Peoples R China.
   [Rensen, Patrick C. N.; Wang, Yanan] Leiden Univ Med Ctr, Dept Med, Div Endocrinol, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands.
C3 Leiden University - Excl LUMC; Leiden University; Leiden University
   Medical Center (LUMC); Leiden University; Leiden University Medical
   Center (LUMC); Leiden University - Excl LUMC; Southern Medical
   University - China; University of Groningen; Leiden University; Leiden
   University Medical Center (LUMC); Leiden University - Excl LUMC; Leiden
   University; Leiden University Medical Center (LUMC); Leiden University -
   Excl LUMC; Leiden University; Leiden University Medical Center (LUMC);
   Leiden University - Excl LUMC; Leiden University; Leiden University
   Medical Center (LUMC); Leiden University - Excl LUMC; Xi'an Jiaotong
   University; Leiden University; Leiden University Medical Center (LUMC)
RP Wang, YA (corresponding author), Leiden Univ Med Ctr, Dept Med, Div Endocrinol, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands.
EM Y.Wang@lumc.nl
RI Goorhuis, Abraham/A-6037-2009; van Dijk, Ko/A-1798-2008; Liu,
   Cong/LMO-3538-2024; Wang, Yanan/C-4143-2019; Kostidis,
   Sarantos/Y-2422-2018; Ying, Zhixiong/V-5029-2018; Kooijman,
   Sander/S-3857-2016; Smits, Wiep Klaas/A-8366-2008; Giera,
   Martin/Y-2413-2018
OI Ying, Zhixiong/0000-0002-3540-7877; Kooijman,
   Sander/0000-0002-0014-5571; Koonen, Debby/0000-0002-1881-8826; Smits,
   Wiep Klaas/0000-0002-7409-2847; Giera, Martin/0000-0003-1684-1894; Zhou,
   Enchen/0000-0002-3739-4934; Wang, Yanan/0000-0002-0327-0458; Liu,
   Cong/0000-0002-2852-8953
FU Leiden University Fund/Mulder-Hamelers Fonds [W18307-2-53, 82170876];
   National Natural Science Foundation of China [91617027]; VENI grant of
   the Netherlands Organization for Scientific Research-NWO [435004007];
   Early Career Scientist Hotel grant of the Netherlands Organization for
   Health Research and Development-ZonMW; Netherlands Cardiovascular
   Research Initiative; Dutch Heart Foundation [CVON-GENIUS-2]; Netherlands
   Heart Foundation [2009T038]; Leiden University Fund/Elise Mathilde Fund;
   National Natural Science Foundation of China's grant; China Scholarship
   Council's grant; Chinese "Thousand Talents Plan" (Young Talents);
   Shaanxi Province "Thousand Talents Plan" (Young Talents) [W213045-2];
   Department of Science and Technology Foundation's grant [82200936]; Plan
   A of the Foundation of Xi'an Jiaotong University [201506170051]; 
   [2021SF-021]
FX This work was supported by the Leiden University Fund/Mulder-Hamelers
   Fonds grant W18307-2-53 (to YW); grant 82170876 of the National Natural
   Science Foundation of China (to YW); VENI grant 91617027 of the
   Netherlands Organization for Scientific Research-NWO (to YW); Early
   Career Scientist Hotel grant 435004007 of the Netherlands Organization
   for Health Research and Development-ZonMW (to YW); the Netherlands
   Cardiovascular Research Initiative, an initiative with support of the
   Dutch Heart Foundation, with grant CVON-GENIUS-2 (to PCNR) and grant
   (CVON-IN-CONTROL II) (to DPYK); the Netherlands Heart Foundation grant
   2009T038 (to PCNR); grant W213045-2 of the Leiden University Fund/Elise
   Mathilde Fund (to ZL); the National Natural Science Foundation of
   China's grant 82200936 (to ZL); and the China Scholarship Council's
   grant 201506170051 (to ZL). The project was also supported by the
   Chinese "Thousand Talents Plan" (Young Talents) (to YW), the Shaanxi
   Province "Thousand Talents Plan" (Young Talents) (to YW), the Department
   of Science and Technology Foundation's grant 2021SF-021 (to YW), and
   Plan A of the Foundation of Xi'an Jiaotong University (to YW).
CR Benítez-Páez A, 2020, MSYSTEMS, V5, DOI 10.1128/mSystems.00857-19
   Bhattacharyya A, 2014, PHYSIOL REV, V94, P329, DOI 10.1152/physrev.00040.2012
   Blaak EE, 2020, BENEF MICROBES, V11, P411, DOI 10.3920/BM2020.0057
   Boets E, 2017, J PHYSIOL-LONDON, V595, P541, DOI 10.1113/JP272613
   Bouter KEC, 2018, CLIN TRANSL GASTROEN, V9, DOI 10.1038/s41424-018-0025-4
   Canfora EE, 2022, GUT MICROBES, V14, DOI 10.1080/19490976.2021.2009297
   Cao Y, 2014, BIOINFORMATICS, V30, P1674, DOI 10.1093/bioinformatics/btu104
   Chambers Edward S, 2018, Curr Nutr Rep, V7, P198, DOI 10.1007/s13668-018-0248-8
   Chijiiwa R, 2020, MICROBIOME, V8, DOI 10.1186/s40168-019-0779-2
   Coppola S, 2022, JAMA NETW OPEN, V5
   Cypess AM, 2010, CURR OPIN PEDIATR, V22, P478, DOI 10.1097/MOP.0b013e32833a8d6e
   Depommier C, 2019, NAT MED, V25, P1096, DOI 10.1038/s41591-019-0495-2
   Dotson CD, 2007, J NEUROSCI, V27, P11242, DOI 10.1523/JNEUROSCI.1227-07.2007
   Duck LW, 2007, INFLAMM BOWEL DIS, V13, P1191, DOI 10.1002/ibd.20237
   Edgar RC, 2013, NAT METHODS, V10, P996, DOI [10.1038/NMETH.2604, 10.1038/nmeth.2604]
   Frost F, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0219489
   Fu LM, 2012, BIOINFORMATICS, V28, P3150, DOI 10.1093/bioinformatics/bts565
   Gao ZG, 2009, DIABETES, V58, P1509, DOI 10.2337/db08-1637
   Hu SX, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21041542
   Kooijman S, 2015, DIABETOLOGIA, V58, P2637, DOI 10.1007/s00125-015-3727-0
   Kostidis S, 2017, ANAL CHIM ACTA, V980, P1, DOI 10.1016/j.aca.2017.05.011
   Ley RE, 2008, SCIENCE, V320, P1647, DOI 10.1126/science.1155725
   Li H, 2009, BIOINFORMATICS, V25, P1754, DOI [10.1093/bioinformatics/btp324, 10.1093/bioinformatics/btp352, 10.1093/bioinformatics/btp698]
   Li Z, 2018, GUT, V67, P1269, DOI 10.1136/gutjnl-2017-314050
   Lin HV, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035240
   Magoc T, 2011, BIOINFORMATICS, V27, P2957, DOI 10.1093/bioinformatics/btr507
   Matsuzawa-Nagata N, 2008, METABOLISM, V57, P1071, DOI 10.1016/j.metabol.2008.03.010
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Most J, 2020, EXP GERONTOL, V133, DOI 10.1016/j.exger.2020.110875
   Noguchi H, 2006, NUCLEIC ACIDS RES, V34, P5623, DOI 10.1093/nar/gkl723
   Ogata H, 1999, NUCLEIC ACIDS RES, V27, P29, DOI 10.1093/nar/27.1.29
   Qiao Y, 2013, APPL MICROBIOL BIOT, V97, P1689, DOI 10.1007/s00253-012-4323-6
   Quiroga R, 2020, EXP MOL MED, V52, P1048
   Rensen PCN, 1997, J LIPID RES, V38, P1070
   Reynolds A, 2019, LANCET, V393, P434, DOI 10.1016/S0140-6736(18)31809-9
   SCHMITT MG, 1976, GASTROENTEROLOGY, V70, P211
   Sengupta S, 2006, J GASTROEN HEPATOL, V21, P209, DOI 10.1111/j.1440-1746.2006.04213.x
   Shi QY, 2022, LANCET, V399, P259, DOI 10.1016/S0140-6736(21)01640-8
   Suárez-Zamorano N, 2015, NAT MED, V21, P1497, DOI 10.1038/nm.3994
   Tomcik K, 2011, ANAL BIOCHEM, V410, P110, DOI 10.1016/j.ab.2010.11.030
   van den Hoek AM, 2014, DIABETES OBES METAB, V16, P537, DOI 10.1111/dom.12252
   Van Klinken JB, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0036162
   Wang MH, 2016, SCI REP-UK, V6, DOI 10.1038/srep25399
   Wen B, 2017, BMC BIOINFORMATICS, V18, DOI 10.1186/s12859-017-1579-y
   Westerterp M, 2006, ARTERIOSCL THROM VAS, V26, P2552, DOI 10.1161/01.ATV.0000243925.65265.3c
   Wu H, 2020, CELL METAB, V32, P379, DOI 10.1016/j.cmet.2020.06.011
   Zeng Q, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-49462-w
   Zhao LP, 2018, SCIENCE, V359, P1151, DOI 10.1126/science.aao5774
NR 48
TC 21
Z9 23
U1 2
U2 23
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA
EI 2379-3708
J9 JCI INSIGHT
JI JCI Insight
PD FEB 22
PY 2023
VL 8
IS 4
AR e166655
DI 10.1172/jci.insight.166655
PG 17
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 9E1IT
UT WOS:000936547600001
PM 36810253
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU He, SK
   Wang, JH
   Li, T
   Yin, S
   Cui, JW
   Xiao, YF
   Tang, Y
   Wang, J
   Bai, YJ
AF He, Si-Ke
   Wang, Jia-Hao
   Li, Tao
   Yin, Shan
   Cui, Jian-Wei
   Xiao, Yun-Fei
   Tang, Yin
   Wang, Jia
   Bai, Yun-Jin
TI Sleep and circadian rhythm disturbance in kidney stone disease: a
   narrative review
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE circadian rhythm disturbance; circadian clock; sleep disorder; circadian
   clock gene; kidney stone disease
ID CALCIUM-OXALATE CRYSTAL; VITAMIN-D STATUS; METABOLIC SYNDROME;
   OXALOBACTER-FORMIGENES; INSULIN-RESISTANCE; OXIDATIVE STRESS; ERB-ALPHA;
   EXPERIMENTAL COLITIS; GENERAL-POPULATION; DIABETES-MELLITUS
AB The circadian rhythm generated by circadian clock genes functions as an internal timing system. Since the circadian rhythm controls abundant physiological processes, the circadian rhythm evolved in organisms is salient for adaptation to environmental change. A disturbed circadian rhythm is a trigger for numerous pathological events. Recently, accumulated data have indicated that kidney stone disease (KSD) is related to circadian rhythm disturbance. However, the mechanism between them has not been fully elucidated. In this narrative review, we summarized existing evidence to illustrate the possible association between circadian rhythm disturbance and KSD based on the epidemiological studies and risk factors that are linked to circadian rhythm disturbance and discuss some chronotherapies for KSD. In summary, KSD is associated with systemic disorders. Metabolic syndrome, inflammatory bowel disease, and microbiome dysbiosis are the major risk factors supported by sufficient data to cause KSD in patients with circadian rhythm disturbance, while others including hypertension, vitamin D deficiency, parathyroid gland dysfunction, and renal tubular damage/dysfunction need further investigation. Then, some chronotherapies for KSD were confirmed to be effective, but the molecular mechanism is still unclear.
C1 [He, Si-Ke; Wang, Jia-Hao; Cui, Jian-Wei; Xiao, Yun-Fei; Tang, Yin; Wang, Jia; Bai, Yun-Jin] Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu, Peoples R China.
   [Li, Tao] Guizhou Med Univ, Affiliated Hosp, Dept Urol, Guiyang, Peoples R China.
   [Yin, Shan] North Sichuan Med Coll, Dept Urol, Affiliated Hosp, Nanchong, Peoples R China.
C3 Sichuan University; Guizhou Medical University; North Sichuan Medical
   University
RP Bai, YJ (corresponding author), Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu, Peoples R China.
EM baiyunjin@wchscu.cn
RI Wang, Jiahao/GSD-4570-2022; Li, Tao/HTQ-4759-2023
FU National Natural Science Foundation of China [82203298]; PostDoctor
   Research Project, West China Hospital, Sichuan University [2020HXBH027];
   Sichuan Science and Technology Program [2022YFS0306]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This study was funded by
   the National Natural Science Foundation of China (Grant no. 82203298),
   the PostDoctor Research Project, West China Hospital, Sichuan University
   (2020HXBH027), and the Sichuan Science and Technology Program
   (2022YFS0306).
CR Abu Salman L, 2020, CURR CARDIOL REP, V22, DOI 10.1007/s11886-020-1257-y
   Aggarwal A, 2017, CELL REP, V21, P2367, DOI 10.1016/j.celrep.2017.11.004
   Agrawal R, 2021, CLOCKS SLEEP, V3, P387, DOI 10.3390/clockssleep3030025
   Alefishat E, 2016, INT J OCCUP MED ENV, V29, P859, DOI 10.13075/ijomeh.1896.00657
   Alelign T, 2018, ADV UROL, V2018, DOI 10.1155/2018/3068365
   Amimanan P, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-03213-x
   Ananthakrishnan AN, 2014, CLIN GASTROENTEROL H, V12, P1879, DOI 10.1016/j.cgh.2014.04.021
   Antonelli JA, 2014, EUR UROL, V66, P724, DOI 10.1016/j.eururo.2014.06.036
   Baek M, 2019, P NATL ACAD SCI USA, V116, P10435, DOI 10.1073/pnas.1815360116
   Barghouthy Y, 2021, WORLD J UROL, V39, P2895, DOI 10.1007/s00345-020-03561-w
   Bayon V, 2022, BMJ OPEN, V12, DOI 10.1136/bmjopen-2021-053591
   Borghi L, 1999, KIDNEY INT, V55, P2397, DOI 10.1046/j.1523-1755.1999.00483.x
   Bouillon R, 2018, BEST PRACT RES CL EN, V32, P669, DOI 10.1016/j.beem.2018.09.014
   Brainard J, 2015, ANESTHESIOLOGY, V122, P1170, DOI 10.1097/ALN.0000000000000596
   Brocato J, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2015-008590
   Cappuccio FP, 1999, J HYPERTENS, V17, P1017, DOI 10.1097/00004872-199917070-00019
   Chakradeo PS, 2018, SLEEP MED, V52, P188, DOI 10.1016/j.sleep.2018.08.002
   Chan KR, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.920261
   Chan MC, 2012, CRIT CARE MED, V40, P246, DOI 10.1097/CCM.0b013e31822f0abe
   Chang CW, 2021, J PERS MED, V11, DOI 10.3390/jpm11111154
   Chang JT, 2020, NEW ENGL J MED, V383, P2652, DOI 10.1056/NEJMra2002697
   Chaput JP, 2013, PREV MED, V57, P872, DOI 10.1016/j.ypmed.2013.09.022
   Charles PY, 2021, UROLITHIASIS, V49, P327, DOI 10.1007/s00240-020-01239-x
   Cheungpasitporn W, 2015, QJM-INT J MED, V108, P205, DOI 10.1093/qjmed/hcu195
   Cho H, 2012, NATURE, V485, P123, DOI 10.1038/nature11048
   Cho JW, 2019, WORLD J MENS HEALTH, V37, P261, DOI 10.5534/wjmh.180045
   Chou FF, 2005, SURGERY, V137, P426, DOI 10.1016/j.surg.2004.12.010
   Chua ECP, 2013, P NATL ACAD SCI USA, V110, P14468, DOI 10.1073/pnas.1222647110
   Chung JH, 2016, NATURE, V536, P446, DOI 10.1038/nature19062
   Chutipongtanate S, 2013, J BIOL INORG CHEM, V18, P299, DOI 10.1007/s00775-012-0974-0
   Corica D, 2016, J CROHNS COLITIS, V10, P226, DOI 10.1093/ecco-jcc/jjv138
   Costello HM, 2022, PHYSIOL REV, V102, P1669, DOI 10.1152/physrev.00045.2021
   Cui SY, 2022, SLEEP BREATH, V26, P2025, DOI 10.1007/s11325-021-02535-5
   Cupisti A, 2014, J NEPHROL, V27, P477, DOI 10.1007/s40620-014-0068-x
   Cury DB, 2013, INT J NEPHROL RENOV, V6, P139, DOI 10.2147/IJNRD.S45466
   D'Ambrosio V, 2022, EXPERT REV CLIN PHAR, V15, P407, DOI 10.1080/17512433.2022.2082943
   Dallmann R, 2010, CHRONOBIOL INT, V27, P1317, DOI 10.3109/07420528.2010.489166
   Davalos M, 2010, J ENDOUROL, V24, P339, DOI 10.1089/end.2009.0205
   Delezie J, 2012, FASEB J, V26, P3321, DOI 10.1096/fj.12-208751
   Deng F, 2020, DIS MARKERS, V2020, DOI 10.1155/2020/6486238
   Dhondup T, 2018, AM J KIDNEY DIS, V72, P790, DOI 10.1053/j.ajkd.2018.06.012
   Diallo AB, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23116136
   Dincer MT, 2022, MED SCI MONITOR, V28, DOI 10.12659/MSM.936497
   Ding Q, 2019, UROL INT, V103, P156, DOI 10.1159/000496208
   Doi M, 2010, NAT MED, V16, P67, DOI 10.1038/nm.2061
   Domrongkitchaiporn S., 2012, Urolithiasis, P195, DOI [10.1007/978-1-4471-4387-1_23, DOI 10.1007/978-1-4471-4387-1_23]
   Dopp JM, 2007, CURR HYPERTENS REP, V9, P529, DOI 10.1007/s11906-007-0095-2
   Douma LG, 2018, FREE RADICAL BIO MED, V119, P108, DOI 10.1016/j.freeradbiomed.2017.11.024
   Drager LF, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012065
   Ducy P, 2023, NEURON, V111, P1847, DOI 10.1016/j.neuron.2023.05.018
   Egstrand S, 2022, KIDNEY INT, V101, P1232, DOI 10.1016/j.kint.2022.02.018
   Egstrand S, 2020, KIDNEY INT, V98, P1461, DOI 10.1016/j.kint.2020.06.034
   Eisner BH, 2012, UROLOGY, V80, P1007, DOI 10.1016/j.urology.2012.04.041
   Elkoushy MA, 2012, UROLOGY, V79, P781, DOI 10.1016/j.urology.2011.09.004
   Erden ES, 2014, ENDOCRINE, V45, P311, DOI 10.1007/s12020-013-0022-z
   Estanislau TB, 2022, CURR PHARM DESIGN, V28, P2478, DOI 10.2174/1381612828666220729091451
   Fagagnini S, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0185193
   Fagiani F, 2022, SIGNAL TRANSDUCT TAR, V7, DOI 10.1038/s41392-022-00899-y
   Fan MY, 2020, EUR HEART J, V41, P1182, DOI 10.1093/eurheartj/ehz849
   Fan XW, 2021, CHRONOBIOL INT, V38, P1776, DOI 10.1080/07420528.2021.1962904
   Fatima N, 2020, PFLUG ARCH EUR J PHY, V472, P513, DOI 10.1007/s00424-020-02381-6
   Foster GE, 2010, HYPERTENSION, V56, P369, DOI 10.1161/HYPERTENSIONAHA.110.152108
   Foster RG, 2020, INTERFACE FOCUS, V10, DOI 10.1098/rsfs.2019.0098
   Ganesan C, 2020, JAMA SURG, V155, P861, DOI 10.1001/jamasurg.2020.2423
   Gao H, 2022, FRONT CELL INFECT MI, V12, DOI 10.3389/fcimb.2022.953392
   Gao YY, 2020, CHRONOBIOL INT, V37, P29, DOI 10.1080/07420528.2019.1683570
   Ge WH, 2023, J LIPID RES, V64, DOI 10.1016/j.jlr.2023.100390
   Giglio S, 2021, J NEPHROL, V34, P2073, DOI 10.1007/s40620-021-01032-y
   Goldbeter A, 2021, BIOCHEM PHARMACOL, V191, DOI 10.1016/j.bcp.2021.114482
   Gomelsky M, 2002, TRENDS BIOCHEM SCI, V27, P497, DOI 10.1016/S0968-0004(02)02181-3
   GOODMAN HO, 1995, J UROLOGY, V153, P301, DOI 10.1097/00005392-199502000-00003
   Gooley JJ, 2016, P NUTR SOC, V75, P440, DOI 10.1017/S0029665116000288
   Grandner M, 2018, J CLIN SLEEP MED, V14, P1031, DOI 10.5664/jcsm.7176
   Grimaldi B, 2010, CELL METAB, V12, P509, DOI 10.1016/j.cmet.2010.10.005
   Gumz ML, 2023, HYPERTENSION, V80, P503, DOI 10.1161/HYPERTENSIONAHA.122.19372
   Gupta S., 2018, Kidney stones: Mechanism of formation, pathogenesis and possible treatments
   Henry CJ, 2020, NUTR DIABETES, V10, DOI 10.1038/s41387-020-0109-6
   Herbert J, 2022, BMC UROL, V22, DOI 10.1186/s12894-021-00951-z
   Hergenhan S, 2020, J MOL BIOL, V432, P3700, DOI 10.1016/j.jmb.2019.12.044
   Hill AJ, 2022, J UROLOGY, V207, P851, DOI 10.1097/JU.0000000000002331
   Hirayama S, 2010, CLIN CHIM ACTA, V411, P253, DOI 10.1016/j.cca.2009.11.017
   Hou HF, 2018, J GLOB HEALTH, V8, DOI 10.7189/jogh.08.010405
   Huo MY, 2022, CARDIOVASC RES, V118, P2859, DOI 10.1093/cvr/cvab336
   Jiang YG, 2017, HONG KONG MED J, V23, P462, DOI 10.12809/hkmj164904
   Johri N, 2017, UROLITHIASIS, V45, P535, DOI 10.1007/s00240-016-0954-x
   Jones-Freeman B, 2021, MUCOSAL IMMUNOL, V14, P779, DOI 10.1038/s41385-020-00372-5
   Jouffe C, 2022, P NATL ACAD SCI USA, V119, DOI 10.1073/pnas.2200083119
   Kaufman DW, 2008, J AM SOC NEPHROL, V19, P1197, DOI 10.1681/ASN.2007101058
   Kawai M, 2019, JCI INSIGHT, V4, DOI 10.1172/jci.insight.121798
   Ketha H, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0137350
   Khalili P, 2021, BMC UROL, V21, DOI 10.1186/s12894-021-00905-5
   Khan SR, 2021, NAT REV NEPHROL, V17, P417, DOI 10.1038/s41581-020-00392-1
   Khand TU, 2022, J PAK MED ASSOC, V72, P1302, DOI 10.47391/JPMA.1188
   Kim D, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-88233-4
   Kim YJ, 2011, UROLOGY, V77, P1059, DOI 10.1016/j.urology.2010.07.492
   Kirubarajan A, 2021, CUAJ-CAN UROL ASSOC, V15, pE169, DOI 10.5489/cuaj.6664
   Konishi T, 2021, NUTRITION, V90, DOI 10.1016/j.nut.2021.111247
   Koopman ADM, 2017, J BIOL RHYTHM, V32, P359, DOI 10.1177/0748730417713572
   Kumar R, 2002, EUR UROL, V41, P318, DOI 10.1016/S0302-2838(02)00040-4
   Lamia KA, 2011, NATURE, V480, P552, DOI 10.1038/nature10700
   LAZAR MA, 1990, J BIOL CHEM, V265, P12859
   Le Martelot G, 2009, PLOS BIOL, V7, DOI 10.1371/journal.pbio.1000181
   Lee J, 2013, MOL CELL BIOL, V33, P2327, DOI 10.1128/MCB.01421-12
   Lehnert M, 2018, CHRONOBIOL INT, V35, P724, DOI 10.1080/07420528.2018.1424719
   Leone V, 2015, CELL HOST MICROBE, V17, P681, DOI 10.1016/j.chom.2015.03.006
   Lewis DA, 2013, FRONT CELL INFECT MI, V3, DOI 10.3389/fcimb.2013.00041
   Li H, 2019, J HUM HYPERTENS, V33, P218, DOI 10.1038/s41371-018-0135-1
   Li HL, 2022, COMMUN BIOL, V5, DOI 10.1038/s42003-022-03725-x
   Li Q, 2021, FRONT CELL INFECT MI, V11, DOI 10.3389/fcimb.2021.648175
   Li T, 2022, AGING DIS, V13, P8, DOI 10.14336/AD.2021.0728
   Liang X, 2015, P NATL ACAD SCI USA, V112, P10479, DOI 10.1073/pnas.1501305112
   Libório AB, 2012, INT UROL NEPHROL, V44, P1473, DOI 10.1007/s11255-011-0116-6
   Liu JL, 2021, CELL MOL GASTROENTER, V12, P251, DOI 10.1016/j.jcmgh.2021.02.008
   Liu W, 2023, BMC MED GENOMICS, V16, DOI 10.1186/s12920-023-01520-z
   Liu XJ, 2017, INFLAMM BOWEL DIS, V23, P1741, DOI 10.1097/MIB.0000000000001265
   Lucas RJ, 2001, BEHAV BRAIN RES, V125, P97, DOI 10.1016/S0166-4328(01)00274-1
   Madore F, 1998, AM J HYPERTENS, V11, P46, DOI 10.1016/S0895-7061(97)00371-3
   Madore F, 1998, AM J KIDNEY DIS, V32, P802, DOI 10.1016/S0272-6386(98)70136-2
   Makarem N, 2020, CURR HYPERTENS REP, V22, DOI 10.1007/s11906-020-1025-9
   Mancusi C, 2020, HIGH BLOOD PRESS CAR, V27, P515, DOI 10.1007/s40292-020-00408-8
   Marcheva B, 2010, NATURE, V466, P627, DOI 10.1038/nature09253
   Marques FZ, 2011, HYPERTENSION, V58, P1093, DOI 10.1161/HYPERTENSIONAHA.111.180729
   Martelli M, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph19158919
   Masood T, 2015, DRUG DISCOV THER, V9, P70, DOI 10.5582/ddt.2015.01002
   Masri S, 2018, NAT MED, V24, P1795, DOI 10.1038/s41591-018-0271-8
   McAlpine CS, 2016, CIRC RES, V119, P131, DOI 10.1161/CIRCRESAHA.116.308034
   Meijer JH, 2010, EUR J NEUROSCI, V32, P2143, DOI 10.1111/j.1460-9568.2010.07522.x
   Meydan N, 2003, SCAND J UROL NEPHROL, V37, P64, DOI 10.1080/00365590310008730
   Miller AW, 2022, NAT REV UROL, V19, P695, DOI 10.1038/s41585-022-00647-5
   Moriya R, 2023, SLEEP MED, V106, P106, DOI 10.1016/j.sleep.2023.03.028
   MUNROE SH, 1991, J BIOL CHEM, V266, P22083
   Murray SE, 2014, WORLD J SURG, V38, P542, DOI 10.1007/s00268-013-2285-1
   Muschialli L, 2024, NUTR METAB CARDIOVAS, V34, P559, DOI 10.1016/j.numecd.2023.09.011
   Nakamura N, 2023, HYPERTENS RES, V46, P2179, DOI 10.1038/s41440-023-01360-5
   Nakashima A, 2018, HYPERTENSION, V72, P746, DOI 10.1161/HYPERTENSIONAHA.118.11075
   Nolan Paul B, 2017, Prev Med Rep, V7, P211, DOI 10.1016/j.pmedr.2017.07.004
   Oh SK, 2019, P NATL ACAD SCI USA, V116, P21140, DOI 10.1073/pnas.1907595116
   Oh-oka K, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0098016
   Pagel R, 2017, FASEB J, V31, P4707, DOI 10.1096/fj.201700141RR
   Paliouras C., 2012, Nephrol Res Rev, V4, P58, DOI [10.4081/nr.2012.e14, DOI 10.4081/NR.2012.E14]
   Pallesen S, 2021, FRONT PSYCHOL, V12, DOI 10.3389/fpsyg.2021.638252
   Pan XY, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms13011
   Pan XY, 2013, CIRCULATION, V128, P1758, DOI 10.1161/CIRCULATIONAHA.113.002885
   Parizadeh M, 2023, TRENDS MOL MED, V29, P789, DOI 10.1016/j.molmed.2023.07.002
   Parsons MJ, 2015, INT J OBESITY, V39, P842, DOI 10.1038/ijo.2014.201
   Patel SR, 2022, CURR UROL REP, V23, P47, DOI 10.1007/s11934-022-01088-8
   Paulose JK, 2019, ISCIENCE, V19, P1202, DOI 10.1016/j.isci.2019.09.007
   Peerapen P, 2023, ADV NUTR, V14, P555, DOI 10.1016/j.advnut.2023.03.002
   Perez AA, 2018, J SURG RES, V232, P564, DOI 10.1016/j.jss.2018.07.028
   Pérez-Mendoza M, 2014, CHRONOBIOL INT, V31, P815, DOI 10.3109/07420528.2014.908898
   Pietroiusti A, 2010, OCCUP ENVIRON MED, V67, P54, DOI 10.1136/oem.2009.046797
   Piovezan RD, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0180901
   Pochetti P, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17144922
   POLONSKY KS, 1988, NEW ENGL J MED, V318, P1231, DOI 10.1056/NEJM198805123181903
   Qian JY, 2013, DIABETES, V62, P3469, DOI 10.2337/db12-1543
   Qiu F, 2021, TRANSL ANDROL UROL, V10, P3646, DOI 10.21037/tau-21-689
   Randall A, 1937, ANN SURG, V105, P1009, DOI 10.1097/00000658-193706000-00014
   Reutrakul S, 2014, ANN NY ACAD SCI, V1311, P151, DOI 10.1111/nyas.12355
   Rhodes V, 2022, SENSORS-BASEL, V22, DOI 10.3390/s22155843
   Richards J, 2014, BLOOD PRESS MONIT, V19, P249, DOI 10.1097/MBP.0000000000000060
   Richards J, 2014, J BIOL CHEM, V289, P11791, DOI 10.1074/jbc.M113.531095
   Rodríguez D, 2015, ADV CHRONIC KIDNEY D, V22, P266, DOI 10.1053/j.ackd.2015.03.005
   Romano A, 2015, CHRONOBIOL INT, V32, P842, DOI 10.3109/07420528.2015.1048867
   Sadowski SM, 2018, J CLIN ENDOCR METAB, V103, P2189, DOI 10.1210/jc.2017-02506
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Schou A, 2022, AM J HUM BIOL, V34, DOI 10.1002/ajhb.23756
   Sener TE, 2017, UROLOGY, V99, DOI 10.1016/j.urology.2016.09.032
   Seo SH, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-45951-0
   Shi DM, 2019, FRONT PHYSIOL, V10, DOI 10.3389/fphys.2019.00423
   Shi SQ, 2013, CURR BIOL, V23, P372, DOI 10.1016/j.cub.2013.01.048
   Shi Z, 2021, J INTERN MED, V289, P851, DOI 10.1111/joim.13204
   Shirasu-Hiza MM, 2007, CURR BIOL, V17, pR353, DOI 10.1016/j.cub.2007.03.049
   Girón-Prieto MS, 2016, INT UROL NEPHROL, V48, P1243, DOI 10.1007/s11255-016-1290-3
   Smith RP, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0222394
   Smolensky MH, 2015, CHRONOBIOL INT, V32, P1029, DOI 10.3109/07420528.2015.1072002
   Song L, 2023, TRANSL BEHAV MED, V13, P183, DOI 10.1093/tbm/ibac089
   Song QL, 2020, CELL CYCLE, V19, P2600, DOI 10.1080/15384101.2020.1810401
   Spatola L, 2018, METABOLISM, V83, P225, DOI 10.1016/j.metabol.2018.02.008
   Staub O, 2023, AM J PHYSIOL-RENAL, V325, pF629, DOI 10.1152/ajprenal.00211.2023
   Stern JM, 2016, UROLITHIASIS, V44, P399, DOI 10.1007/s00240-016-0882-9
   Stone EF, 2012, PLOS PATHOG, V8, DOI 10.1371/journal.ppat.1002445
   Taleb Z, 2022, FRONT CELL INFECT MI, V12, DOI 10.3389/fcimb.2022.773413
   Tallman JE, 2023, UROLITHIASIS, V51, DOI 10.1007/s00240-023-01421-x
   Tan E, 2014, CURR OPIN CLIN NUTR, V17, P343, DOI 10.1097/MCO.0000000000000061
   Tavasoli S, 2019, INT UROL NEPHROL, V51, P101, DOI 10.1007/s11255-018-1965-z
   Taylor EN, 2006, AM J KIDNEY DIS, V47, P780, DOI 10.1053/j.ajkd.2006.01.024
   Thaiss CA, 2016, CELL, V167, P1495, DOI 10.1016/j.cell.2016.11.003
   Thaiss CA, 2014, CELL, V159, P514, DOI 10.1016/j.cell.2014.09.048
   Ticinesi A, 2019, KIDNEY INT, V96, P25, DOI 10.1016/j.kint.2019.03.020
   Torricelli FCM, 2014, J UROLOGY, V191, P667, DOI 10.1016/j.juro.2013.09.022
   Troxel SA, 2003, J ENDOUROL, V17, P173, DOI 10.1089/089277903321618743
   Tsai SH, 2018, J CLIN SLEEP MED, V14, P767, DOI 10.5664/jcsm.7102
   Turek FW, 2005, SCIENCE, V308, P1043, DOI 10.1126/science.1108750
   Valladares M, 2015, J PHYSIOL BIOCHEM, V71, P855, DOI 10.1007/s13105-015-0447-3
   van de Pol JAA, 2019, BRIT J CANCER, V120, P368, DOI 10.1038/s41416-018-0356-7
   Vasey C, 2021, NUTRIENTS, V13, DOI 10.3390/nu13103480
   Vieira E, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0111678
   Voigt RM, 2016, ALCOHOL CLIN EXP RES, V40, P335, DOI 10.1111/acer.12943
   Voigt RM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0097500
   Wadei HM, 2012, NAT REV NEPHROL, V8, P602, DOI 10.1038/nrneph.2012.191
   Walker WH, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21249360
   Wang H, 2022, Zhonghua Liu Xing Bing Xue Za Zhi, V43, P1002, DOI 10.3760/cma.j.cn112338-20210930-00760
   Wang JH, 2021, LIFE SCI, V265, DOI 10.1016/j.lfs.2020.118853
   Wang S, 2022, BMC PUBLIC HEALTH, V22, DOI 10.1186/s12889-022-14187-5
   Wang S, 2020, SCI ADV, V6, DOI 10.1126/sciadv.abb5202
   Wang S, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-06568-5
   Wang Z, 2021, INT J MOL MED, V48, DOI 10.3892/ijmm.2021.4982
   Weinberg AE, 2014, EUR UROL, V65, P242, DOI 10.1016/j.eururo.2013.03.026
   Weintraub Y, 2023, DIGEST DIS SCI, V68, P2454, DOI 10.1007/s10620-023-07847-y
   Weintraub Y, 2020, CLIN GASTROENTEROL H, V18, P115, DOI 10.1016/j.cgh.2019.04.013
   Wimalawansa SJ, 2019, BIOLOGY-BASEL, V8, DOI 10.3390/biology8020030
   Wu HZ, 2020, CIRC RES, V126, P1549, DOI 10.1161/CIRCRESAHA.119.315896
   Wulff K, 2009, CURR OPIN GENET DEV, V19, P237, DOI 10.1016/j.gde.2009.03.007
   Xiao YF, 2023, BMC PUBLIC HEALTH, V23, DOI 10.1186/s12889-023-15934-y
   Xiao ZH, 2022, MAYO CLIN PROC, V97, P2016, DOI 10.1016/j.mayocp.2022.04.007
   Xie J, 2020, BMC MICROBIOL, V20, DOI 10.1186/s12866-020-01734-6
   Xing C, 2020, FRONT GENET, V11, DOI 10.3389/fgene.2020.610496
   Xu H, 2021, CLIN CHIM ACTA, V512, P12, DOI 10.1016/j.cca.2020.11.011
   Yamaguchi ST, 2022, NEUROSCI RES, V183, P76, DOI 10.1016/j.neures.2022.07.005
   Yang ST, 2009, ENDOCRINOLOGY, V150, P2153, DOI 10.1210/en.2008-0705
   Yin S, 2022, SLEEP HEALTH, V8, P671, DOI 10.1016/j.sleh.2022.08.003
   Yuan TH, 2023, BMC MICROBIOL, V23, DOI 10.1186/s12866-023-02891-0
   Zani F, 2013, MOL METAB, V2, P292, DOI 10.1016/j.molmet.2013.06.006
   Zarrinpar A, 2014, CELL METAB, V20, P1006, DOI 10.1016/j.cmet.2014.11.008
   Zhang EE, 2010, NAT REV MOL CELL BIO, V11, P764, DOI 10.1038/nrm2995
   Zhang EE, 2010, NAT MED, V16, P1152, DOI 10.1038/nm.2214
   Zhang ZQ, 2020, EXP THER MED, V20, DOI 10.3892/etm.2020.9224
   Zhou T, 2013, J UROLOGY, V190, P1416, DOI 10.1016/j.juro.2013.05.016
   Zimmet P, 2019, J INTERN MED, V286, P181, DOI 10.1111/joim.12924
   Zuber AM, 2009, P NATL ACAD SCI USA, V106, P16523, DOI 10.1073/pnas.0904890106
NR 230
TC 7
Z9 7
U1 7
U2 20
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD NOV 27
PY 2023
VL 14
AR 1293685
DI 10.3389/fendo.2023.1293685
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AM1Z0
UT WOS:001118803400001
PM 38089624
OA gold
DA 2025-06-11
ER

PT J
AU De Long, NE
   Holloway, AC
AF De Long, Nicole E.
   Holloway, Alison C.
TI Early-life chemical exposures and risk of metabolic syndrome
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Review
DE obesity; pesticides; polybrominated diphenyl ethers; heavy metals;
   acrylamide; endocrine-disrupting chemicals
ID POLYBROMINATED DIPHENYL ETHERS; ENDOCRINE-DISRUPTING CHEMICALS; ADVERSE
   PREGNANCY OUTCOMES; DIETARY ACRYLAMIDE INTAKE; CHILDHOOD BLOOD-PRESSURE;
   PRENATAL LEAD-EXPOSURE; DE-NOVO LIPOGENESIS; FLAME RETARDANTS;
   BIRTH-WEIGHT; OXIDATIVE STRESS
AB The global prevalence of obesity has been increasing at a staggering pace, with few indications of any decline, and is now one of the major public health challenges worldwide. While obesity and metabolic syndrome (MetS) have historically thought to be largely driven by increased caloric intake and lack of exercise, this is insufficient to account for the observed changes in disease trends. There is now increasing evidence to suggest that exposure to synthetic chemicals in our environment may also play a key role in the etiology and pathophysiology of metabolic diseases. Importantly, exposures occurring in early life (in utero and early childhood) may have a more profound effect on life-long risk of obesity and MetS. This narrative review explores the evidence linking early-life exposure to a suite of chemicals that are common contaminants associated with food production (pesticides; imidacloprid, chlorpyrifos, and glyphosate) and processing (acrylamide), in addition to chemicals ubiquitously found in our household goods (brominated flame retardants) and drinking water (heavy metals) and changes in key pathways important for the development of MetS and obesity.
C1 [De Long, Nicole E.; Holloway, Alison C.] McMaster Univ, Dept Obstet & Gynecol, RM HSC-3N52,1280 Main St West, Hamilton, ON L8S 4K1, Canada.
C3 McMaster University
RP Holloway, AC (corresponding author), McMaster Univ, Dept Obstet & Gynecol, RM HSC-3N52,1280 Main St West, Hamilton, ON L8S 4K1, Canada.
EM hollow@mcmaster.ca
CR Abbasi G, 2016, SCI TOTAL ENVIRON, V545, P299, DOI 10.1016/j.scitotenv.2015.12.028
   Acker CI, 2012, CHEMOSPHERE, V89, P602, DOI 10.1016/j.chemosphere.2012.05.059
   Afeiche M, 2011, ENVIRON HEALTH PERSP, V119, P1436, DOI 10.1289/ehp.1003184
   Agay-Shay K, 2015, ENVIRON HEALTH PERSP, V123, P1030, DOI 10.1289/ehp.1409049
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Allam A. A., 2010, ARCH TOXICOL, V84, P129
   Anderson JC, 2015, SCI TOTAL ENVIRON, V505, P409, DOI 10.1016/j.scitotenv.2014.09.090
   Annola K, 2008, TOXICOL LETT, V182, P50, DOI 10.1016/j.toxlet.2008.08.006
   [Anonymous], 2011, Principles to guide health care transformation in Canada, P1
   [Anonymous], PESTICIDE UTILIZATIO
   [Anonymous], NEW SOIL 10 PLAN SAF
   [Anonymous], USP IMPL EL IMP STAN
   [Anonymous], ENV GEOCHEM HLTH
   [Anonymous], METABOLIC SYNDROME
   [Anonymous], REP JOINT M FAO PAN
   [Anonymous], CAS ASS 100 MILL CAS
   [Anonymous], J EXPO SCI ENV EPIDE
   Arbuckle TE, 2016, CHEMOSPHERE, V163, P270, DOI 10.1016/j.chemosphere.2016.08.023
   Aris A, 2011, REPROD TOXICOL, V31, P528, DOI 10.1016/j.reprotox.2011.02.004
   Arnold M, 2016, CANCER EPIDEMIOL, V41, P8, DOI 10.1016/j.canep.2016.01.003
   Binetti R., 2008, Ann Ist Super Sanita, V44, P12
   Bouvier G, 2005, J TOXICOL ENV HEAL B, V8, P485, DOI 10.1080/10937400591007284
   Brunet JL, 2004, TOXICOL APPL PHARM, V194, P1, DOI 10.1016/j.taap.2003.08.018
   Buser MC, 2014, INT J HYG ENVIR HEAL, V217, P687, DOI 10.1016/j.ijheh.2014.02.005
   Carpenter David O., 2008, Reviews on Environmental Health, V23, P59
   Chang MJ, 2005, J ENVIRON MONITOR, V7, P1349, DOI 10.1039/b509048b
   Chen AM, 2013, ENVIRON SCI TECHNOL, V47, P3902, DOI 10.1021/es3046839
   Chen LM, 2015, ENVIRON POLLUT, V206, P32, DOI 10.1016/j.envpol.2015.06.019
   Chen M, 2014, J AGR FOOD CHEM, V62, P6082, DOI 10.1021/jf501397m
   Curwin BD, 2007, ANN OCCUP HYG, V51, P53, DOI [10.1093/annhyg/mel062, 10.1093/annhug/mel062]
   Dao T, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0138815
   de Araujo JSA, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-3153-3
   de Cock M, 2016, J ENVIRON SCI HEAL A, V51, P178, DOI 10.1080/10934529.2015.1087753
   de Cock M, 2014, ENVIRON INT, V70, P15, DOI 10.1016/j.envint.2014.04.022
   Dessì A, 2012, J MATERN-FETAL NEO M, V25, P13, DOI 10.3109/14767058.2012.714639
   Di Cesare M, 2016, LANCET, V387, P1377, DOI 10.1016/s0140-6736(16)30054-x
   Duarte-Salles T, 2013, ENVIRON HEALTH PERSP, V121, P374, DOI 10.1289/ehp.1205396
   Phung DT, 2013, RISK ANAL, V33, P1596, DOI 10.1111/risa.12023
   Phung DT, 2012, CHEMOSPHERE, V87, P294, DOI 10.1016/j.chemosphere.2011.11.075
   El-Sayyad HI, 2011, NUTRITION, V27, P343, DOI 10.1016/j.nut.2010.11.005
   Erkin-Cakmak A, 2015, ENVIRON HEALTH PERSP, V123, P636, DOI 10.1289/ehp.1408417
   Faulk C, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0104273
   Feng J, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000002859
   Frye CA, 2012, J NEUROENDOCRINOL, V24, P144, DOI 10.1111/j.1365-2826.2011.02229.x
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gochberg-Sarver A, 2012, MOL GENET METAB, V107, P561, DOI 10.1016/j.ymgme.2012.08.012
   Gomes MP, 2016, ENVIRON POLLUT, V218, P402, DOI 10.1016/j.envpol.2016.07.019
   Gordon CJ, 2000, TOXICOLOGY, V146, P1, DOI 10.1016/S0300-483X(00)00158-X
   Grün F, 2009, MOL CELL ENDOCRINOL, V304, P19, DOI 10.1016/j.mce.2009.02.018
   Grün F, 2006, ENDOCRINOLOGY, V147, pS50, DOI 10.1210/en.2005-1129
   Guo WH, 2016, CHEMOSPHERE, V150, P505, DOI 10.1016/j.chemosphere.2015.11.032
   Hanson MA, 2008, BASIC CLIN PHARMACOL, V102, P90, DOI 10.1111/j.1742-7843.2007.00186.x
   Harley KG, 2011, AM J EPIDEMIOL, V174, P885, DOI 10.1093/aje/kwr212
   Hatch EE, 2008, ENVIRON HEALTH-GLOB, V7, DOI 10.1186/1476-069X-7-27
   Hawkesworth S, 2013, INT J EPIDEMIOL, V42, P176, DOI 10.1093/ije/dys215
   Heindel JJ, 2015, ENVIRON HEALTH-GLOB, V14, DOI 10.1186/s12940-015-0042-7
   Herrmann KM, 1999, ANNU REV PLANT PHYS, V50, P473, DOI 10.1146/annurev.arplant.50.1.473
   Hoffman K, 2015, ENVIRON HEALTH PERSP, V123, P160, DOI 10.1289/ehp.1408669
   Hoppe AA, 2007, OBESITY, V15, P2942, DOI 10.1038/oby.2007.351
   Howell GE, 2016, TOXICOL IN VITRO, V32, P181, DOI 10.1016/j.tiv.2016.01.002
   Hu H, 2015, SCI TOTAL ENVIRON, V505, P56, DOI 10.1016/j.scitotenv.2014.09.085
   Iszatt N, 2015, ENVIRON HEALTH PERSP, V123, P730, DOI 10.1289/ehp.1308005
   James-Todd TM, 2016, ENVIRON HEALTH-GLOB, V15, DOI 10.1186/s12940-016-0136-x
   Jeschke P, 2011, J AGR FOOD CHEM, V59, P2897, DOI 10.1021/jf101303g
   Kadawathagedara M, 2016, ENVIRON RES, V149, P189, DOI 10.1016/j.envres.2016.05.019
   Kalish BT, 2014, ENVIRON RES, V133, P327, DOI 10.1016/j.envres.2014.06.004
   Kapoor U, 2010, J TOXICOL SCI, V35, P577, DOI 10.2131/jts.35.577
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kimura-Kuroda J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0032432
   Knez J, 2013, REPROD BIOMED ONLINE, V26, P440, DOI 10.1016/j.rbmo.2013.02.005
   Lee HR, 2013, J CELL MOL MED, V17, P1, DOI 10.1111/j.1582-4934.2012.01649.x
   Legler J, 2015, J CLIN ENDOCR METAB, V100, P1278, DOI 10.1210/jc.2014-4326
   Lema SC, 2008, ENVIRON HEALTH PERSP, V116, P1694, DOI 10.1289/ehp.11570
   Li B, 2016, ENVIRON SCI POLLUT R, V23, P19246, DOI 10.1007/s11356-016-7142-y
   Lignell S, 2013, ENVIRON HEALTH-GLOB, V12, DOI 10.1186/1476-069X-12-44
   Lopez-Espinosa MJ, 2015, ENVIRON SCI TECHNOL, V49, P10108, DOI 10.1021/acs.est.5b01793
   Martini CN, 2016, J BIOCHEM MOL TOXIC, V30, P404, DOI 10.1002/jbt.21804
   Martini CN, 2012, TOXICOL IN VITRO, V26, P1007, DOI 10.1016/j.tiv.2012.04.017
   Mathiesen L, 2014, BASIC CLIN PHARMACOL, V115, P93, DOI 10.1111/bcpt.12228
   Meggs WJ, 2007, J MED TOXICOL, V3, P89, DOI 10.1007/BF03160916
   Mercier F, 2011, ENVIRON SCI TECHNOL, V45, P6716, DOI 10.1021/es200925h
   Mesnage R, 2015, ENVIRON HEALTH-GLOB, V14, DOI 10.1186/s12940-015-0056-1
   Motojyuku M, 2008, J CHROMATOGR B, V875, P509, DOI 10.1016/j.jchromb.2008.10.003
   Mühlig Y, 2016, OBES REV, V17, P235, DOI 10.1111/obr.12357
   Müller MHB, 2016, ENVIRON INT, V89-90, P38, DOI 10.1016/j.envint.2015.12.032
   MUSSALORAUHAMAA H, 1986, ARCH ENVIRON HEALTH, V41, P49, DOI 10.1080/00039896.1986.9935765
   Nash JT, 2013, J TOXICOL ENV HEAL A, V76, P142, DOI 10.1080/15287394.2012.738457
   National Institute for Emergency Medicine, 2015, Getting Started Guide, National Instruments, C A T Ii, Sinking Output, C Series, P1
   Nelson JW, 2010, ENVIRON HEALTH PERSP, V118, P197, DOI 10.1289/ehp.0901165
   Norman Rosana E., 2013, Reviews on Environmental Health, V28, P59, DOI 10.1515/reveh-2012-0033
   Padilla MA, 2010, INT J ENV RES PUB HE, V7, P3332, DOI 10.3390/ijerph7093332
   Panzica GC, 2011, J TOXICOL ENV HEAL B, V14, P449, DOI 10.1080/10937404.2011.578562
   Park Y, 2013, J AGR FOOD CHEM, V61, P255, DOI 10.1021/jf3039814
   Patisaul HB, 2013, J BIOCHEM MOL TOXIC, V27, P124, DOI 10.1002/jbt.21439
   Pedersen M, 2012, ENVIRON HEALTH PERSP, V120, P1739, DOI 10.1289/ehp.1205327
   Peltier MR, 2015, J REPROD IMMUNOL, V107, P20, DOI 10.1016/j.jri.2014.11.002
   Rahman A, 2016, SCI TOTAL ENVIRON, V569, P1022, DOI 10.1016/j.scitotenv.2016.06.134
   Rancière F, 2015, ENVIRON HEALTH-GLOB, V14, DOI 10.1186/s12940-015-0036-5
   Ranjani H, 2016, INDIAN J MED RES, V143, P160, DOI 10.4103/0971-5916.180203
   Rasinger JD, 2014, TOXICOLOGY, V321, P1, DOI 10.1016/j.tox.2014.03.006
   Rawi SM, 2012, AFR J PHARM PHARMACO, V6, P1367, DOI 10.5897/AJPP12.148
   Rawn DFK, 2014, SCI TOTAL ENVIRON, V468, P622, DOI 10.1016/j.scitotenv.2013.08.014
   Regnier SM, 2014, BBA-MOL BASIS DIS, V1842, P520, DOI 10.1016/j.bbadis.2013.05.028
   Riederer AM, 2010, ENVIRON SCI TECHNOL, V44, P483, DOI 10.1021/es902479h
   Rudich A, 1998, DIABETES, V47, P1562, DOI 10.2337/diabetes.47.10.1562
   Sargis RM, 2010, OBESITY, V18, P1283, DOI 10.1038/oby.2009.419
   Serme-Gbedo YK, 2016, ENVIRON HEALTH-GLOB, V15, DOI 10.1186/s12940-016-0134-z
   Skröder H, 2016, ENVIRON RES, V151, P628, DOI 10.1016/j.envres.2016.08.028
   Skröder H, 2015, ENVIRON RES, V140, P205, DOI 10.1016/j.envres.2015.03.038
   Slotkin TA, 2005, ENVIRON HEALTH PERSP, V113, P1291, DOI 10.1289/ehp.8133
   Smith U, 2016, J INTERN MED, V280, P465, DOI 10.1111/joim.12540
   Solomon KR, 2014, REV ENVIRON CONTAM T, V231, P13, DOI 10.1007/978-3-319-03865-0_2
   Sorensen N, 1999, EPIDEMIOLOGY, V10, P370, DOI 10.1097/00001648-199907000-00006
   Stasinska A, 2014, SCI TOTAL ENVIRON, V493, P554, DOI 10.1016/j.scitotenv.2014.06.001
   Stieb DM, 2016, ENVIRON RES, V148, P513, DOI 10.1016/j.envres.2016.04.025
   Struger J, 2015, ENVIRON POLLUT, V204, P289, DOI 10.1016/j.envpol.2015.03.038
   Svechnikov K, 2014, ASIAN J ANDROL, V16, P50, DOI 10.4103/1008-682X.122199
   Tabb MM, 2006, MOL ENDOCRINOL, V20, P475, DOI 10.1210/me.2004-0513
   Takahashi M, 2009, ARCH TOXICOL, V83, P785, DOI 10.1007/s00204-009-0418-y
   Toor HK, 2013, PESTIC BIOCHEM PHYS, V105, P1, DOI 10.1016/j.pestbp.2012.10.001
   Trasande L, 2013, ENVIRON HEALTH PERSP, V121, P501, DOI 10.1289/ehp.1205526
   Trasande L, 2012, JAMA-J AM MED ASSOC, V308, P1113, DOI 10.1001/2012.jama.11461
   Tsoi MF, 2016, AM J MED, V129, P1213, DOI 10.1016/j.amjmed.2016.05.042
   Ueyama J, 2014, J OCCUP HEALTH, V56, P461, DOI 10.1539/joh.14-0077-OA
   Van Stempvoort DR, 2014, CHEMOSPHERE, V95, P455, DOI 10.1016/j.chemosphere.2013.09.095
   Veiga-Lopez A, 2016, AM J PHYSIOL-ENDOC M, V310, pE238, DOI 10.1152/ajpendo.00425.2015
   Vohra Prerna, 2015, Toxicol Int, V22, P119, DOI 10.4103/0971-6580.172270
   Vorkamp K, 2014, ARCH ENVIRON CON TOX, V67, P9, DOI 10.1007/s00244-013-9988-z
   Wang A, 2016, FERTIL STERIL, V106, P905, DOI 10.1016/j.fertnstert.2016.07.1076
   Whitehead R, 2016, HORM MOL BIOL CLIN I, V25, P171, DOI 10.1515/hmbci-2015-0052
   Yanovski JA, 2015, APPETITE, V93, P3, DOI 10.1016/j.appet.2015.03.028
   Yoshioka N, 2011, J CHROMATOGR A, V1218, P3675, DOI 10.1016/j.chroma.2011.04.021
   Zheng TZ, 2016, ANN GLOB HEALTH, V82, P41, DOI 10.1016/j.aogh.2016.01.008
NR 133
TC 60
Z9 69
U1 0
U2 41
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2017
VL 10
BP 101
EP 109
DI 10.2147/DMSO.S95296
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EO6OA
UT WOS:000396811200001
PM 28367067
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Delgado-Lista, J
   Perez-Martinez, P
   Garcia-Rios, A
   Perez-Caballero, AI
   Perez-Jimenez, F
   Lopez-Miranda, J
AF Delgado-Lista, Javier
   Perez-Martinez, Pablo
   Garcia-Rios, Antonio
   Perez-Caballero, Ana I.
   Perez-Jimenez, Francisco
   Lopez-Miranda, Jose
TI Mediterranean Diet and Cardiovascular Risk: Beyond Traditional Risk
   Factors
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Mediterranean diet; cardiovascular prevention; cardiovascular risk
   factors; olive oil
ID VIRGIN OLIVE-OIL; POSTPRANDIAL ENDOTHELIAL FUNCTION; POLYUNSATURATED
   FATTY-ACIDS; BLOOD MONONUCLEAR-CELLS; GENE-EXPRESSION CHANGES; METABOLIC
   SYNDROME; RED WINE; FISH-OIL; HEALTHY-SUBJECTS; DISEASE RISK
AB A strict adherence to the Mediterranean Diet (MedDiet) has repeatedly been linked to a low risk of cardiovascular disease in several situations. Initially, the mechanisms considered as possible causes of this were based on the effects of this dietary pattern on the so-called traditional risk factors (especially lipids and blood pressure). However, the high relative reduction in the prevalence of cardiovascular morbidity and mortality were not proportional to the limited findings about regulation of those traditional risk factors. In addition to several studies confirming the above effects, current research on the MedDiet is being focused on defining its effects on non-traditional risk factors, such as endothelial function, inflammation, oxidative stress, or on controlling the conditions which predispose people to cardiovascular events, such as obesity, metabolic syndrome or type 2 diabetes mellitus. In the current article, after briefly reviewing the known effects of the MedDiet on the traditional risk factors, we will mainly focus on reviewing the current evidence about the effects that this dietary pattern exerts on alternative factors, including postprandial lipemia or coagulation, among others, as well as providing a short review on future directions.
C1 [Delgado-Lista, Javier; Perez-Martinez, Pablo; Garcia-Rios, Antonio; Perez-Caballero, Ana I.; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Univ Cordoba, Ciber Fisiopatol Obesidad & Nutr CIBEROBN, Hosp Univ Reina Sofia, Unidad Lipidos & Arteriosclerosis,IMIBIC,Inst Sal, Cordoba, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Universidad
   de Cordoba
RP Lopez-Miranda, J (corresponding author), Hosp Univ Reina Sofia, Unidad Lipidos & Arteriosclerosis, Serv Med Interna, Cordoba 14004, Spain.
EM jlopezmir@uco.es
RI Delgado-Lista, Javier/KAM-7412-2024; Tejada, Silvia/L-7297-2014;
   Jimenez, Francisco/AAJ-9559-2021; Lopez-Miranda, Jose/Y-8306-2019; Perez
   Martinez, Pablo/AEL-6176-2022
OI Delgado Lista, Francisco Javier/0000-0002-2982-2716; Perez-Caballero,
   Ana Isabel/0000-0001-6315-1453; Lopez-Miranda, Jose/0000-0002-8844-0718;
   Perez Martinez, Pablo/0000-0001-7716-8117
FU Spanish Ministry of Science and Innovation [AGL2009-12270, SAF07-62005,
   FIS PI10/01041, PI10/02412]; Consejeria de Economia, Innovacion y
   Ciencia, Proyectos de Investigacion de Excelencia, Junta de Andalucia
   [P06-CTS-01425, CTS5015, AGR922]; Consejeria de Salud, Junta de
   Andalucia [07/43, PI0193/09, PI-0252/09, PI-0058/10]; Fondo Europeo de
   Desarrollo Regional (FEDER); Ministerio de Economia y Competitividad
   [AGL2012/39615]
FX Supported partly by public funding through research grants from the
   Spanish Ministry of Science and Innovation (AGL2009-12270 to J L-M,
   SAF07-62005 to F. Perez-Jimenez and FIS PI10/01041 to P. Perez-Martinez,
   PI10/02412 to F. Perez-Jimenez); Consejeria de Economia, Innovacion y
   Ciencia, Proyectos de Investigacion de Excelencia, Junta de Andalucia
   (P06-CTS-01425 to J. Lopez-Miranda, CTS5015 and AGR922 to F.
   Perez-Jimenez); Consejeria de Salud, Junta de Andalucia (07/43, and
   PI0193/09 to J. Lopez-Miranda, PI-0252/09 to J. Delgado-Lista, and
   PI-0058/10 to P. Perez-Martinez); Fondo Europeo de Desarrollo Regional
   (FEDER). The CIBEROBN is an initiative of the Instituto de Salud Carlos
   III, Madrid, Spain. Also supported by Ministerio de Economia y
   Competitividad (AGL2012/39615 to J L-M).
CR Agostoni C, 2011, EFSA J, V9, DOI 10.2903/j.efsa.2011.2033
   Ambrose JA, 2004, J AM COLL CARDIOL, V43, P1731, DOI 10.1016/j.jacc.2003.12.047
   Anderson RA, 2001, ATHEROSCLEROSIS, V154, P475, DOI 10.1016/S0021-9150(00)00499-8
   [Anonymous], 2010, Fat detection: Taste, texture, and post ingestive effects, DOI DOI 10.1201/9781420067767-C17
   Antonopoulou S, 2006, J MED FOOD, V9, P356, DOI 10.1089/jmf.2006.9.356
   Avellone G, 1998, NUTR METAB CARDIOVAS, V8, P287
   Bach-Faig A, 2006, PUBLIC HEALTH NUTR, V9, P1110, DOI 10.1017/S1368980007668499
   Bae JH, 2003, INT J CARDIOL, V87, P259, DOI 10.1016/S0167-5273(02)00347-9
   Bellido C, 2004, AM J CLIN NUTR, V80, P1487, DOI 10.1093/ajcn/80.6.1487
   Bellido C, 2006, NUTR METAB CARDIOVAS, V16, P524, DOI 10.1016/j.numecd.2005.09.007
   Bermudez B, 2011, CURR PHARM DESIGN, V17, P831, DOI 10.2174/138161211795428957
   Berry SEE, 2008, J NUTR, V138, P1910, DOI 10.1093/jn/138.10.1910
   Borissoff JI, 2011, NEW ENGL J MED, V364, P1746, DOI 10.1056/NEJMra1011670
   Bravo-Herrera MD, 2004, NUTR METAB CARDIOVAS, V14, P128, DOI 10.1016/S0939-4753(04)80032-2
   Brunelleschi S, 2007, PHARMACOL RES, V56, P542, DOI 10.1016/j.phrs.2007.10.001
   Brunner H, 2005, J HYPERTENS, V23, P233, DOI 10.1097/00004872-200502000-00001
   Buscemi S, 2009, EUR J CLIN INVEST, V39, P339, DOI 10.1111/j.1365-2362.2009.02091.x
   Camargo A, 2012, BRIT J NUTR, V108, P500, DOI 10.1017/S0007114511005812
   Camargo A, 2010, BMC GENOMICS, V11, DOI 10.1186/1471-2164-11-253
   Carluccio MA, 1999, ARTERIOSCL THROM VAS, V19, P220, DOI 10.1161/01.ATV.19.2.220
   Carter SJ, 2010, ATHEROSCLEROSIS, V210, P630, DOI 10.1016/j.atherosclerosis.2009.12.035
   Chrysohoou C, 2004, J AM COLL CARDIOL, V44, P152, DOI 10.1016/j.jacc.2004.03.039
   Ciancarelli MGT, 2011, THROMB RES, V128, P124, DOI 10.1016/j.thromres.2011.03.015
   Clarke R, 2011, J INHERIT METAB DIS, V34, P83, DOI 10.1007/s10545-010-9235-y
   Cuevas AM, 2004, BIOL RES, V37, P225
   Dai J, 2008, CIRCULATION, V117, P169, DOI 10.1161/CIRCULATIONAHA.107.710699
   Dedoussis GV, 2008, CLIN CHEM LAB MED, V46, P990, DOI 10.1515/CCLM.2008.191
   Delgado-Lista J, 2008, AM J CLIN NUTR, V87, P317, DOI 10.1093/ajcn/87.2.317
   Delgado-Lista J, 2012, BRIT J NUTR, V107, pS201, DOI 10.1017/S0007114512001596
   Delgado-Lista J, 2011, CURR PHARM DESIGN, V17, P778, DOI 10.2174/138161211795428876
   Delgado-Lista J, 2011, CLIN NUTR, V30, P234, DOI 10.1016/j.clnu.2010.08.006
   Delgado-Lista J, 2011, J CLIN ENDOCR METAB, V96, pE816, DOI 10.1210/jc.2010-2455
   Den Heijer M, 2005, J THROMB HAEMOST, V3, P292, DOI 10.1111/j.1538-7836.2005.01141.x
   Desjardins F, 2006, ACTA CLIN BELG, V61, P326, DOI 10.1179/acb.2006.052
   Di Minno MND, 2010, THROMB HAEMOSTASIS, V103, P942, DOI 10.1160/TH09-06-0393
   Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440
   Esposito K, 2006, PUBLIC HEALTH NUTR, V9, P1073, DOI 10.1017/S1368980007668529
   Estruch R, 2010, P NUTR SOC, V69, P333, DOI 10.1017/S0029665110001539
   Filion KB, 2010, BMC CARDIOVASC DISOR, V10, DOI 10.1186/1471-2261-10-24
   Finch Jennifer M., 2010, Cardiovascular & Hematological Disorders - Drug Targets, V10, P241
   Fuentes F, 2008, BRIT J NUTR, V100, P159, DOI 10.1017/S0007114508888708
   Fuentes F, 2001, ANN INTERN MED, V134, P1115, DOI 10.7326/0003-4819-134-12-200106190-00011
   Fung TT, 2005, AM J CLIN NUTR, V82, P163
   Gillet L, 2011, BIOCHIMIE, V93, P4, DOI 10.1016/j.biochi.2010.02.005
   Gillingham LG, 2011, LIPIDS, V46, P209, DOI 10.1007/s11745-010-3524-y
   Giugliano D, 2008, CURR OPIN LIPIDOL, V19, P63, DOI 10.1097/MOL.0b013e3282f2fa4d
   González-Correa JA, 2008, J AGR FOOD CHEM, V56, P7872, DOI 10.1021/jf801502z
   Goode GK, 1997, CIRCULATION, V96, P2802, DOI 10.1161/01.CIR.96.9.2802
   Halcox JPJ, 2002, CIRCULATION, V106, P653, DOI 10.1161/01.CIR.0000025404.78001.D8
   Harris WS, 2008, ATHEROSCLEROSIS, V197, P12, DOI 10.1016/j.atherosclerosis.2007.11.008
   Jackson KG, 2012, ATHEROSCLEROSIS, V220, P22, DOI 10.1016/j.atherosclerosis.2011.08.012
   Jansen S, 2000, AM J CLIN NUTR, V72, P36
   Jimenez-Gomez Yolanda, 2009, Atherosclerosis, V204, pe70, DOI 10.1016/j.atherosclerosis.2008.09.011
   Jiménez-Morales AI, 2011, J CLIN ENDOCR METAB, V96, pE1694, DOI 10.1210/jc.2011-1056
   Junker R, 2001, THROMB RES, V101, P355, DOI 10.1016/S0049-3848(00)00421-7
   Junker R, 2001, THROMB HAEMOSTASIS, V85, P280
   Kang YJ, 2011, PHARMACOL THERAPEUT, V129, P321, DOI 10.1016/j.pharmthera.2010.11.004
   Karantonis HC, 2006, NUTR METAB CARDIOVAS, V16, P174, DOI 10.1016/j.numecd.2005.07.003
   Karantonis HC, 2002, J AGR FOOD CHEM, V50, P1150, DOI 10.1021/jf010923t
   Karatzi K, 2008, J AM COLL NUTR, V27, P448, DOI 10.1080/07315724.2008.10719724
   Kolovou GD, 2011, CURR VASC PHARMACOL, V9, P258
   Konstantinidou V, 2009, FOLIA BIOL-PRAGUE, V55, P85
   Kris-Etherton PM, 2002, CIRCULATION, V106, P2747, DOI 10.1161/01.CIR.0000038493.65177.94
   Lapointe A, 2005, J NUTR, V135, P410, DOI 10.1093/jn/135.3.410
   Lavie CJ, 2009, J AM COLL CARDIOL, V54, P585, DOI 10.1016/j.jacc.2009.02.084
   Leaf A, 2005, CIRCULATION, V112, P2762, DOI 10.1161/CIRCULATIONAHA.105.549527
   Lichtenstein AH, 2006, CIRCULATION, V114, P82, DOI 10.1161/CIRCULATIONAHA.106.176158
   Llorente-Cortés V, 2010, ATHEROSCLEROSIS, V208, P442, DOI 10.1016/j.atherosclerosis.2009.08.004
   López-Miranda J, 2010, NUTR METAB CARDIOVAS, V20, P284, DOI 10.1016/j.numecd.2009.12.007
   Lopez-Miranda J, 2007, BRIT J NUTR, V98, P458, DOI 10.1017/S000711450774268X
   Lopez-Miranda J, 2007, MOL NUTR FOOD RES, V51, P1249, DOI 10.1002/mnfr.200600307
   Lucas L, 2011, CURR PHARM DESIGN, V17, P754, DOI 10.2174/138161211795428911
   Marin C, 2012, AGE, V34, P1309, DOI 10.1007/s11357-011-9305-6
   Marin C, 2011, AM J CLIN NUTR, V93, P267, DOI 10.3945/ajcn.110.006866
   Mena MP, 2009, AM J CLIN NUTR, V89, P248, DOI 10.3945/ajcn.2008.26094
   Mente A, 2009, ARCH INTERN MED, V169, P659, DOI 10.1001/archinternmed.2009.38
   Mezzano D, 2003, PATHOPHYSIOL HAEMO T, V33, P472, DOI 10.1159/000083848
   Mezzano D, 2003, EUR J CLIN NUTR, V57, P439, DOI 10.1038/sj.ejcn.1601558
   Mihas C, 2011, CURR VASC PHARMACOL, V9, P271, DOI 10.2174/157016111795495530
   MORRIS MC, 1993, CIRCULATION, V88, P523, DOI 10.1161/01.CIR.88.2.523
   Mozaffarian D, 2004, CIRCULATION, V110, P368, DOI 10.1161/01.CIR.0000138154.00779.A5
   Pacheco YM, 2007, BRIT J NUTR, V98, P260, DOI 10.1017/S0007114507701666
   Panagiotakos DB, 2008, VASC MED, V13, P113, DOI 10.1177/1358863x07087731
   Panagiotakos DB, 2009, INT J EPIDEMIOL, V38, P856, DOI 10.1093/ije/dyp142
   Park K, 2010, CURR ATHEROSCLER REP, V12, P414, DOI 10.1007/s11883-010-0138-z
   PATSCH JR, 1992, ARTERIOSCLER THROMB, V12, P1336, DOI 10.1161/01.ATV.12.11.1336
   De la Cruz JP, 2010, BRIT J NUTR, V104, P560, DOI 10.1017/S0007114510000929
   Pellegrini N, 2010, NUTR METAB CARDIOVAS, V20, P64, DOI 10.1016/j.numecd.2009.02.003
   Perez-Herrera A, 2012, MOL NUTR FOOD RES, V56, P510, DOI 10.1002/mnfr.201100533
   Pérez-Jiménez F, 1999, ATHEROSCLEROSIS, V145, P351, DOI 10.1016/S0021-9150(99)00116-1
   Perez-Jimenez F, 2005, EUR J CLIN INVEST, V35, P421, DOI 10.1111/j.1365-2362.2005.01516.x
   Pérez-Jiménez F, 2002, ATHEROSCLEROSIS, V163, P385, DOI 10.1016/S0021-9150(02)00033-3
   Pérez-Jiménez F, 2006, PUBLIC HEALTH NUTR, V9, P1083, DOI 10.1017/S1368980007668566
   Perez-Martinez P, 2011, NUTR METAB CARDIOVAS, V21, P39, DOI 10.1016/j.numecd.2009.07.008
   Perez-Martinez P, 2008, ATHEROSCLEROSIS SUPP, V9, P49, DOI 10.1016/j.atherosclerosissup.2008.05.005
   Perez-Martinez P, 2007, ATHEROSCLEROSIS, V194, pE141, DOI 10.1016/j.atherosclerosis.2006.11.033
   Perez-Martinez P, 2011, CURR VASC PHARMACOL, V9, P287, DOI 10.2174/157016111795495495
   Perez-Martinez P, 2010, CLIN SCI, V119, P251, DOI 10.1042/CS20100015
   Perez-Martinez P, 2010, ATHEROSCLEROSIS SUPP, V11, P39, DOI 10.1016/j.atherosclerosissup.2010.03.002
   Perez-Martinez P, 2010, ATHEROSCLEROSIS, V209, P533, DOI 10.1016/j.atherosclerosis.2009.09.023
   Phang M, 2011, SEMIN THROMB HEMOST, V37, P199, DOI 10.1055/s-0031-1273084
   Pitsavos C, 2005, AM J CLIN NUTR, V82, P694, DOI 10.1093/ajcn/82.3.694
   Rallidis LS, 2009, AM J CLIN NUTR, V90, P263, DOI 10.3945/ajcn.2008.27290
   RASMUSSEN O, 1994, METABOLISM, V43, P1406, DOI 10.1016/0026-0495(94)90036-1
   Renaud Serge, 2002, Curr Atheroscler Rep, V4, P419, DOI 10.1007/s11883-002-0045-z
   Riediger ND, 2009, J AM DIET ASSOC, V109, P668, DOI 10.1016/j.jada.2008.12.022
   Roche HM, 1998, AM J CLIN NUTR, V68, P552, DOI 10.1093/ajcn/68.3.552
   Ruano J, 2005, J AM COLL CARDIOL, V46, P1864, DOI 10.1016/j.jacc.2005.06.078
   Salas-Salvadó J, 2008, EUR J CLIN NUTR, V62, P651, DOI 10.1038/sj.ejcn.1602762
   Sanders TAB, 2000, ATHEROSCLEROSIS, V149, P413, DOI 10.1016/S0021-9150(99)00335-4
   Sawashita N, 2006, NUTRITION, V22, P661, DOI 10.1016/j.nut.2006.02.002
   Schini-Kerth VB, 2010, ADV PHARMACOL, V60, P133, DOI [10.1016/S1054-3589(10)60004-X, 10.1016/B978-0-12-385061-4.00006-4]
   Seo T, 2005, CURR OPIN LIPIDOL, V16, P11, DOI 10.1097/00041433-200502000-00004
   Serhan CN, 2008, NAT REV IMMUNOL, V8, P349, DOI 10.1038/nri2294
   Serrano-Martinez M, 2005, EUR J NUTR, V44, P348, DOI 10.1007/s00394-004-0532-9
   Shidfar F, 2011, INT J FOOD SCI NUTR, V62, P289, DOI 10.3109/09637486.2010.529072
   Silva KDR, 2003, ATHEROSCLEROSIS, V166, P73, DOI 10.1016/S0021-9150(02)00306-4
   Singh I, 2008, NUTR METAB CARDIOVAS, V18, P127, DOI 10.1016/j.numecd.2006.09.001
   SIRTORI CR, 1986, AM J CLIN NUTR, V44, P635, DOI 10.1093/ajcn/44.5.635
   Smith RD, 2003, BRIT J NUTR, V90, P597, DOI 10.1079/BJN2003953
   Stirban A, 2010, AM J CLIN NUTR, V91, P808, DOI 10.3945/ajcn.2009.28374
   Tavazzi L, 2008, LANCET, V372, P1223, DOI 10.1016/S0140-6736(08)61239-8
   Temme EHM, 1999, THROMB HAEMOSTASIS, V81, P259, DOI 10.1055/s-0037-1614454
   Thies F, 2003, LANCET, V361, P477, DOI 10.1016/S0140-6736(03)12468-3
   Thomazella MCD, 2011, AM J CARDIOL, V108, P1523, DOI 10.1016/j.amjcard.2011.07.008
   Torres-Urrutia C, 2011, BLOOD COAGUL FIBRIN, V22, P197, DOI 10.1097/MBC.0b013e328343f7da
   Tripoli E, 2005, NUTR RES REV, V18, P98, DOI 10.1079/NRR200495
   Turpeinen AM, 1999, NUTR METAB CARDIOVAS, V9, P65
   Ungvari Z, 2010, AM J PHYSIOL-HEART C, V299, pH18, DOI 10.1152/ajpheart.00260.2010
   Visioli F, 1998, NUTR REV, V56, P142
   Williams C M, 2001, Nutr Metab Cardiovasc Dis, V11, P51
   Williams KT, 2010, BIOFACTORS, V36, P19, DOI 10.1002/biof.71
   Yamagishi K, 2008, AM HEART J, V156, P965, DOI 10.1016/j.ahj.2008.06.017
   Zhu JX, 2012, AMINO ACIDS, V43, P1243, DOI 10.1007/s00726-011-1196-4
   Zrelli H, 2011, J AGR FOOD CHEM, V59, P4473, DOI 10.1021/jf104151d
NR 135
TC 29
Z9 29
U1 1
U2 25
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PY 2016
VL 56
IS 5
BP 788
EP 801
DI 10.1080/10408398.2012.726660
PG 14
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA DJ1RM
UT WOS:000373981000006
PM 25118147
DA 2025-06-11
ER

PT J
AU Amirullah, NA
   Abdullah, E
   Abidin, NZ
   Abdullah, N
   Manickam, S
AF Amirullah, Nur Amalina
   Abdullah, Erlina
   Abidin, Nurhayati Zainal
   Abdullah, Noorlidah
   Manickam, Sivakumar
TI Therapeutic potential of mushrooms: A review on NF-κB modulation in
   chronic inflammation
SO FOOD BIOSCIENCE
LA English
DT Review
DE Bioactive compounds; Chronic diseases; Fungal metabolites; Inflammation;
   Medicinal mushrooms; Neuroinflammation
ID DEEP EUTECTIC SOLVENT; OXIDATIVE STRESS; ANTIINFLAMMATORY PROPERTIES;
   MEDICINAL MUSHROOM; METABOLIC SYNDROME; EDIBLE MUSHROOMS; P38 MAPK;
   PATHWAY; TARGET; CANCER
AB Numerous mushroom species are valued not just for their flavor but also for their health advantages. Historically, these mushrooms have been utilized for medicinal purposes across different parts of the world. Research has revealed that metabolites derived from these fungi have health benefits. Recently, there has been a growing interest in understanding how these fungal metabolites provide their healing effects and comprehend their mechanisms of action. A primary focus is the nuclear factor NF-kappa B, kappa B, a family of transcription factors essential for regulating inflammation, cell proliferation, and apoptosis. Dysregulation and abnormal activation of NF-kappa B kappa B proteins are associated with a variety of diseases. Various studies have investigated mushroom compounds and their impact on various conditions, including inflammatory bowel disease, gut health, metabolic syndrome, neuroinflammation, liver injury, renal and pulmonary diseases, and autoimmune disorders. This review provides a comprehensive summary of the NF-kappa B kappa B signaling pathway and other related inflammatory pathways. It discusses the bioactive compounds found in mushrooms, their potential to alleviate various diseases, and the specific inflammatory pathways, particularly NF-kappa B, kappa B, that these bioactives target.
C1 [Amirullah, Nur Amalina; Abdullah, Erlina; Abidin, Nurhayati Zainal; Abdullah, Noorlidah] Univ Malaya, Inst Biol Sci, Fac Sci, Kuala Lumpur 50603, Malaysia.
   [Amirullah, Nur Amalina] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Nutr, Serdang 43400, Malaysia.
   [Abdullah, Erlina] Lincoln Univ Coll, Fac Appl Sci, Dept Biotechnol, Petaling Jaya 47301, Selangor, Malaysia.
   [Manickam, Sivakumar] Univ Teknol Brunei, Fac Engn, Petr & Chem Engn Dept, BE-1410 Bandar Seri Begawan, Brunei.
C3 Universiti Malaya; Universiti Putra Malaysia; Lincoln University
   College; University of Technology Brunei
RP Amirullah, NA (corresponding author), Univ Malaya, Inst Biol Sci, Fac Sci, Kuala Lumpur 50603, Malaysia.
EM amalinaamirullah@upm.edu.my
RI MANICKAM, SIVAKUMAR/I-2228-2014; abdullah, erlina/KCJ-9315-2024; ABIDIN,
   NURHAYATI/B-9429-2010; Abdullah, Noorlidah/B-9290-2010
OI ABDULLAH, ERLINA/0000-0002-6895-1991; MANICKAM,
   SIVAKUMAR/0000-0001-9102-4013
FU Universiti Malaya Special Research Fund Assistance (BKS) [BKS013-2018];
   Universiti Malaya Research University Grant (RU Faculty) [GPF008B-2018];
   Universiti Malaya
FX The authors received support from the Universiti Malaya Special Research
   Fund Assistance (BKS) [BKS013-2018] and the Universiti Malaya Research
   University Grant (RU Faculty) [GPF008B-2018] , which made this work
   possible. The authors thank Universiti Malaya for this support.
CR Abd Wahab NA, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/131607
   Abdullah E, 2022, INT J MED MUSHROOMS, V24, P27, DOI 10.1615/IntJMedMushrooms.2021041548
   Ahmed OM, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10091317
   Ahmed SMU, 2017, BBA-MOL BASIS DIS, V1863, P585, DOI 10.1016/j.bbadis.2016.11.005
   Al Nahdi AMT, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/7054272
   Alberts B., 2002, Molecular Biology of the Cell, V4th, P882
   Altas S, 2011, FOOD CHEM TOXICOL, V49, P2433, DOI 10.1016/j.fct.2011.06.064
   Amirullah NA, 2021, BIOCATAL AGR BIOTECH, V34, DOI 10.1016/j.bcab.2021.102019
   Amirullah NA, 2018, FOOD RES INT, V105, P517, DOI 10.1016/j.foodres.2017.11.023
   Araújo-Rodrigues H, 2024, CARBOHYD POLYM, V333, DOI 10.1016/j.carbpol.2024.121978
   Barbosa JR, 2020, CARBOHYD POLYM, V229, DOI 10.1016/j.carbpol.2019.115550
   Barnabei L, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.716469
   Sanz AB, 2010, J AM SOC NEPHROL, V21, P1254, DOI 10.1681/ASN.2010020218
   Bhambri A, 2022, FRONT MICROBIOL, V13, DOI 10.3389/fmicb.2022.837266
   Bhatt HB, 2015, HEPATOBIL SURG NUTR, V4, P101, DOI 10.3978/j.issn.2304-3881.2015.01.03
   Blanche E. O. C., 2017, Journal of Food, Nutrition and Population Health, V1, P1
   Brignall R, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.00609
   Cao C, 2024, CARBOHYD POLYM, V334, DOI 10.1016/j.carbpol.2024.122030
   Cao CY, 2022, BIOORG CHEM, V125, DOI 10.1016/j.bioorg.2022.105854
   Chaiyama V., 2020, Bioact. Carbohydr. Diet. Fibre, V23, DOI [10.1016/j.bcdf.2020, DOI 10.1016/J.BCDF.2020.100216, 10.1016/j.bcdf.2020.100216]
   Chassaing Benoit, 2014, Curr Protoc Immunol, V104, DOI 10.1002/0471142735.im1525s104
   Chaturvedi VK, 2018, 3 BIOTECH, V8, DOI 10.1007/s13205-018-1358-0
   Chen WW, 2016, MOL MED REP, V13, P3391, DOI 10.3892/mmr.2016.4948
   Cheung P.C.K., 2008, Mushroom as functional foods, DOI DOI 10.1002/9780470367285
   Chien LH, 2023, BIOMED PHARMACOTHER, V165, DOI 10.1016/j.biopha.2023.115080
   Chuang SY, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.664425
   Cichoz-Lach H, 2014, WORLD J GASTROENTERO, V20, P8082, DOI 10.3748/wjg.v20.i25.8082
   Della Latta V, 2015, PHARMACOL RES, V97, P122, DOI 10.1016/j.phrs.2015.04.012
   Deng JS, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/7912763
   Dommermuth R, 2018, PRIMARY CARE, V45, P109, DOI 10.1016/j.pop.2017.10.003
   Du B, 2018, J FUNCT FOODS, V47, P334, DOI 10.1016/j.jff.2018.06.003
   Engelman JA, 2006, NAT REV GENET, V7, P606, DOI 10.1038/nrg1879
   Erol E, 2020, REC NAT PROD, V14, P77, DOI 10.25135/rnp.139.19.04.1263
   Farzaei MH, 2018, NUTRIENTS, V10, DOI 10.3390/nu10070855
   Ferreira ICFR, 2010, ANTI-CANCER AGENT ME, V10, P424
   Fischer M, 2017, ONCOGENE, V36, P3943, DOI 10.1038/onc.2016.502
   Gogoi P, 2019, J FOOD PROCESS ENG, V42, DOI 10.1111/jfpe.13172
   Corrêa RCG, 2016, TRENDS FOOD SCI TECH, V50, P103, DOI 10.1016/j.tifs.2016.01.012
   Corrêa RCG, 2015, FOOD FUNCT, V6, P2155, DOI [10.1039/c5fo00465a, 10.1039/C5FO00465A]
   Guan QD, 2019, J IMMUNOL RES, V2019, DOI 10.1155/2019/7247238
   Guo YB, 2024, INT J BIOL MACROMOL, V267, DOI 10.1016/j.ijbiomac.2024.131385
   Hamza A, 2024, J BIOTECHNOL, V381, P86, DOI 10.1016/j.jbiotec.2023.12.014
   Han JM, 2019, J ETHNOPHARMACOL, V231, P10, DOI 10.1016/j.jep.2018.11.003
   Hassanein EHM, 2022, LIFE SCI, V308, DOI 10.1016/j.lfs.2022.120971
   Hayden MS, 2004, GENE DEV, V18, P2195, DOI 10.1101/gad.1228704
   He GB, 2011, CELL RES, V21, P159, DOI 10.1038/cr.2010.183
   Horn HF, 2007, ONCOGENE, V26, P1306, DOI 10.1038/sj.onc.1210263
   Hu JH, 2021, J HEMATOL ONCOL, V14, DOI 10.1186/s13045-021-01169-0
   Huang F, 2019, CARBOHYD POLYM, V206, P344, DOI 10.1016/j.carbpol.2018.11.012
   Huang Y, 2015, J NUTR BIOCHEM, V26, P1401, DOI 10.1016/j.jnutbio.2015.08.001
   Impellizzeri D, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11020406
   Jaeschke H, 2012, DRUG METAB REV, V44, P88, DOI 10.3109/03602532.2011.602688
   Jiang Z, 2018, INT J MED MUSHROOMS, V20, P119, DOI 10.1615/IntJMedMushrooms.2018025536
   Kahn M, 2014, NAT REV DRUG DISCOV, V13, P513, DOI 10.1038/nrd4233
   Karin M, 1998, CANCER J SCI AM, V4, pS92
   Kaser A, 2010, ANNU REV IMMUNOL, V28, P573, DOI 10.1146/annurev-immunol-030409-101225
   Kawaratani H, 2017, INT J MOL MED, V40, P263, DOI 10.3892/ijmm.2017.3015
   Khare L, 2021, FOOD CHEM, V340, DOI 10.1016/j.foodchem.2020.127979
   Kim H, 2021, INT J BIOL MACROMOL, V169, P122, DOI 10.1016/j.ijbiomac.2020.12.081
   Kim Jung Ha, 2014, J Bone Metab, V21, P233
   Kothari D, 2018, BIOMED PHARMACOTHER, V105, P377, DOI 10.1016/j.biopha.2018.05.138
   Kou RW, 2022, BIOORG CHEM, V121, DOI 10.1016/j.bioorg.2022.105689
   Kou RW, 2021, J AGR FOOD CHEM, V69, P12730, DOI 10.1021/acs.jafc.1c04905
   Kou RW, 2021, J AGR FOOD CHEM, V69, P668, DOI 10.1021/acs.jafc.0c06822
   Krakowska A, 2020, FOOD CHEM, V327, DOI 10.1016/j.foodchem.2020.127084
   Kyriakis JM, 2012, PHYSIOL REV, V92, P689, DOI 10.1152/physrev.00028.2011
   Lau CC, 2013, BMC COMPLEM ALTERN M, V13, DOI 10.1186/1472-6882-13-313
   Lee H, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21041347
   Lee J, 2016, FOOD FUNCT, V7, P3263, DOI 10.1039/c6fo00540c
   Lee W., 2019, Medicinal Mushrooms: Recent Progress in Research and Development, P223
   Leong YK, 2021, CARBOHYD POLYM, V251, DOI 10.1016/j.carbpol.2020.117006
   Li MQ, 2021, FOODS, V10, DOI 10.3390/foods10112680
   Li X, 2020, MOL MED REP, V22, P3418, DOI 10.3892/mmr.2020.11420
   Liang ZX, 2016, PROG NEUROBIOL, V137, P1, DOI 10.1016/j.pneurobio.2015.11.001
   Liu BC, 2018, KIDNEY INT, V93, P568, DOI 10.1016/j.kint.2017.09.033
   Liu JQ, 2022, SIGNAL TRANSDUCT TAR, V7, DOI 10.1038/s41392-021-00762-6
   Liu YT, 2020, INT J BIOL MACROMOL, V162, P935, DOI 10.1016/j.ijbiomac.2020.06.212
   Loboda A, 2016, CELL MOL LIFE SCI, V73, P3221, DOI 10.1007/s00018-016-2223-0
   Lull C, 2005, MEDIAT INFLAMM, P63, DOI 10.1155/MI.2005.63
   Ma B, 2016, FRONT IMMUNOL, V7, DOI 10.3389/fimmu.2016.00378
   Maguire EM, 2019, VASC PHARMACOL, V112, P54, DOI 10.1016/j.vph.2018.08.002
   Manabe I, 2011, CIRC J, V75, P2739, DOI 10.1253/circj.CJ-11-1184
   Medzhitov R, 2010, CELL, V140, P771, DOI 10.1016/j.cell.2010.03.006
   Meng B, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/6029876
   Meng M, 2023, PHYTOMEDICINE, V119, DOI 10.1016/j.phymed.2023.155010
   Miles P. G., 1997, World scientific, DOI [10.1142/3296, DOI 10.1142/3296]
   Mockenhaupt K, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10071609
   Morales D, 2019, J FUNCT FOODS, V60, DOI 10.1016/j.jff.2019.103446
   Morgan MJ, 2011, CELL RES, V21, P103, DOI 10.1038/cr.2010.178
   Morita Y, 2005, ALCOHOL CLIN EXP RES, V29, p277S, DOI 10.1097/01.alc.0000191777.36629.33
   Mulero M. C., 2019, NF-B, IB, and IKK: Integral components of immune system signaling, DOI [10.1007/978-981-13-9367-910, DOI 10.1007/978-981-13-9367-910]
   Muszynska B, 2018, FOOD CHEM, V243, P373, DOI 10.1016/j.foodchem.2017.09.149
   Nakajima S, 2013, FREE RADICAL BIO MED, V65, P162, DOI 10.1016/j.freeradbiomed.2013.06.020
   Nejak-Bowen K, 2013, HEPATOLOGY, V57, P763, DOI 10.1002/hep.26042
   Niu LM, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0156090
   O'Shea JJ, 2015, ANNU REV MED, V66, P311, DOI 10.1146/annurev-med-051113-024537
   Oates JC, 2022, AM J PHYSIOL-RENAL, V322, pF309, DOI 10.1152/ajprenal.00371.2021
   Oeckinghaus A, 2011, NAT IMMUNOL, V12, P695, DOI 10.1038/ni.2065
   Pahl HL, 1999, ONCOGENE, V18, P6853, DOI 10.1038/sj.onc.1203239
   Pamukcu B, 2011, THROMB RES, V128, P117, DOI 10.1016/j.thromres.2011.03.025
   Pan X, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.912014
   Park MH, 2016, CELLS-BASEL, V5, DOI 10.3390/cells5020015
   Patel DK, 2021, MOLECULES, V26, DOI 10.3390/molecules26051359
   Paterson R Russell M, 2014, Biomed J, V37, P357, DOI 10.4103/2319-4170.143502
   Patil J, 2018, ACS SUSTAIN CHEM ENG, V6, P10578, DOI 10.1021/acssuschemeng.8b01915
   Perugorria MJ, 2019, NAT REV GASTRO HEPAT, V16, P121, DOI 10.1038/s41575-018-0075-9
   Polivka J, 2014, PHARMACOL THERAPEUT, V142, P164, DOI 10.1016/j.pharmthera.2013.12.004
   Qi Qian-Rong, 2014, World J Biol Chem, V5, P231, DOI 10.4331/wjbc.v5.i2.231
   Ramos GP, 2019, MAYO CLIN PROC, V94, P155, DOI 10.1016/j.mayocp.2018.09.013
   Ransohoff RM, 2016, SCIENCE, V353, P777, DOI 10.1126/science.aag2590
   Reuter S, 2010, FREE RADICAL BIO MED, V49, P1603, DOI 10.1016/j.freeradbiomed.2010.09.006
   Ronkina N, 2022, ANNU REV BIOCHEM, V91, P505, DOI 10.1146/annurev-biochem-081720-114505
   Roux PP, 2004, MICROBIOL MOL BIOL R, V68, P320, DOI 10.1128/MMBR.68.2.320-344.2004
   Seitz HK, 2018, NAT REV DIS PRIMERS, V4, DOI 10.1038/s41572-018-0014-7
   Sharma V, 2020, BIOMED PHARMACOTHER, V129, DOI 10.1016/j.biopha.2020.110373
   Sheng FY, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010085
   Shi HB, 2017, ONCOTARGET, V8, P12637, DOI 10.18632/oncotarget.14478
   Sillapachaiyaporn C, 2022, FOOD RES INT, V157, DOI 10.1016/j.foodres.2022.111433
   Song LY, 2023, INT J BIOL MACROMOL, V238, DOI 10.1016/j.ijbiomac.2023.124333
   Song XL, 2021, FOOD FUNCT, V12, P4591, DOI [10.1039/d1fo00310k, 10.1039/D1FO00310K]
   Song XL, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21082810
   Subhramanyam CS, 2019, SEMIN CELL DEV BIOL, V94, P112, DOI 10.1016/j.semcdb.2019.05.004
   Taniguchi K, 2018, NAT REV IMMUNOL, V18, P309, DOI 10.1038/nri.2017.142
   Taofiq O, 2016, TRENDS FOOD SCI TECH, V50, P193, DOI 10.1016/j.tifs.2016.02.005
   Teng SS, 2023, CARBOHYD POLYM, V303, DOI 10.1016/j.carbpol.2022.120453
   Thakur M. P., 2020, Indian Phytopathology, V73, P377, DOI 10.1007/s42360-020-00244-9
   Tsopmejio ISN, 2023, J NUTR BIOCHEM, V111, DOI 10.1016/j.jnutbio.2022.109190
   Tsopmejio ISN, 2022, FOOD BIOSCI, V47, DOI 10.1016/j.fbio.2021.101426
   Tung YT, 2020, CURR PHARM DESIGN, V26, P4970, DOI 10.2174/1381612826666200831151316
   Vallée A, 2018, CELL MOL NEUROBIOL, V38, P783, DOI 10.1007/s10571-017-0550-9
   Vezaro FD, 2022, J CHEM TECHNOL BIOT, V97, P3306, DOI 10.1002/jctb.7190
   Volobueva A, 2019, COR VASA, V61, pE48, DOI 10.1016/j.crvasa.2018.06.006
   Wang HH, 2020, PEDIATR GASTROENTERO, V23, P189
   Wang JJ, 2019, NEUROSCI LETT, V704, P106, DOI 10.1016/j.neulet.2019.04.002
   Wang WS, 2023, J ETHNOPHARMACOL, V309, DOI 10.1016/j.jep.2023.116321
   Wang YF, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.792614
   Wang YJ, 2019, MECH AGEING DEV, V184, DOI 10.1016/j.mad.2019.111160
   Wasser SP, 2011, APPL MICROBIOL BIOT, V89, P1323, DOI 10.1007/s00253-010-3067-4
   Wu SJ, 2019, CANCER MED-US, V8, P2252, DOI 10.1002/cam4.2101
   Wu ZQ, 2021, EXP HEMATOL ONCOL, V10, DOI 10.1186/s40164-020-00197-9
   Xiang H, 2021, FOOD SCI HUM WELL, V10, P87, DOI 10.1016/j.fshw.2020.06.001
   Xie ZL, 2019, INT J BIOL MACROMOL, V129, P61, DOI 10.1016/j.ijbiomac.2019.02.023
   Xiong C, 2023, FOOD SCI NUTR, V11, P2152, DOI 10.1002/fsn3.3050
   Xu DW, 2019, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01428
   Xu H, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20010128
   Xu H, 2019, J AGR FOOD CHEM, V67, P10871, DOI 10.1021/acs.jafc.9b04613
   Xu J, 2021, FOOD CHEM TOXICOL, V150, DOI 10.1016/j.fct.2021.112073
   Xu XF, 2011, BIOTECHNOL ADV, V29, P667, DOI 10.1016/j.biotechadv.2011.05.003
   Xu YX, 2014, TRENDS BIOCHEM SCI, V39, P268, DOI 10.1016/j.tibs.2014.04.004
   Yamamoto M, 2021, P JPN ACAD B-PHYS, V97, P145, DOI 10.2183/pjab.97.009
   Yang C, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20205205
   Yang KC, 2016, SCI REP-UK, V6, DOI 10.1038/srep27034
   Ye N, 2014, J MED CHEM, V57, P6930, DOI 10.1021/jm5004733
   Yilmaz ZB, 2003, EMBO J, V22, P121, DOI 10.1093/emboj/cdg004
   Yu H, 2020, SIGNAL TRANSDUCT TAR, V5, DOI 10.1038/s41392-020-00312-6
   Yuan B, 2017, FOOD FUNCT, V8, P2175, DOI [10.1039/c7fo00244k, 10.1039/C7FO00244K]
   Zamakshshari NH, 2023, CHEM BIODIVERS, V20, DOI 10.1002/cbdv.202300111
   Zhang HS, 2015, CELL BIOSCI, V5, DOI 10.1186/s13578-015-0056-4
   Zhang J, 2024, J ETHNOPHARMACOL, V322, DOI 10.1016/j.jep.2023.117656
   Zhang JX, 2022, MOLECULES, V27, DOI 10.3390/molecules27113612
   Zhang Q, 2017, CELL, V168, P37, DOI 10.1016/j.cell.2016.12.012
   Zhang T, 2021, MEDCOMM, V2, P618, DOI 10.1002/mco2.104
   Zhang TZ, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.01257
   Zhang WN, 2022, J FUNCT FOODS, V99, DOI 10.1016/j.jff.2022.105301
   Zhang YF, 2023, MOLECULES, V28, DOI 10.3390/molecules28062760
   Zhang YF, 2023, NUTRIENTS, V15, DOI 10.3390/nu15234904
   Zhang YF, 2022, NUTRIENTS, V14, DOI 10.3390/nu14173477
   Zhao HJ, 2023, INT J BIOL MACROMOL, V230, DOI 10.1016/j.ijbiomac.2023.123241
   Zhao HJ, 2022, J FUNCT FOODS, V95, DOI 10.1016/j.jff.2022.105152
   Zhao HJ, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20194872
   Zhao JH, 2023, INT J BIOL MACROMOL, V239, DOI 10.1016/j.ijbiomac.2023.124291
   Zhao Y, 2024, FRONT PHARMACOL, V15, DOI 10.3389/fphar.2024.1406127
   Zheng R, 2020, TROP J PHARM RES, V19, P2153, DOI 10.4314/tjpr.v19i10.20
   Zhou YF, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.00391
NR 174
TC 3
Z9 3
U1 5
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-4292
EI 2212-4306
J9 FOOD BIOSCI
JI Food Biosci.
PD DEC
PY 2024
VL 62
AR 105059
DI 10.1016/j.fbio.2024.105059
EA SEP 2024
PG 25
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA H8E9T
UT WOS:001325729400001
DA 2025-06-11
ER

PT J
AU Anania, C
   Perla, FM
   Olivero, F
   Pacifico, L
   Chiesa, C
AF Anania, Caterina
   Perla, Francesco Massimo
   Olivero, Francesca
   Pacifico, Lucia
   Chiesa, Claudio
TI Mediterranean diet and nonalcoholic fatty liver disease
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Mediterranean diet; Children; Nonalcoholic fatty liver disease; Adults
ID METABOLIC SYNDROME; GUT MICROBIOTA; WEIGHT-LOSS; CARDIOVASCULAR-DISEASE;
   LIFE-STYLE; VITAMIN-E; INTESTINAL MICROBIOTA; INSULIN-RESISTANCE;
   ADHERENCE; HEALTH
AB Nonalcoholic fatty liver disease (NAFLD) is emerging as the most common chronic liver disease, and is characterized by a wide spectrum of fat-liver disorders that can result in severe liver disease and cirrhosis. Inflammation and oxidative stress are the major risk factors involved in the pathogenesis of NAFLD. Currently, there is no consensus concerning the pharmacological treatment of NAFLD. However, lifestyle interventions based on exercise and a balanced diet for quality and quantity, are considered the cornerstone of NAFLD management. Mediterranean diet (MD), rich in polyunsaturated fats, polyphenols, vitamins and carotenoids, with their anti-inflammatory and antioxidant effects, has been suggested to be effective in preventing cardiovascular risk factors. In adults, MD has also been demonstrated to be efficacious in reducing the risk of metabolic syndrome. However, few studies are available on the effects of the MD in both adult and pediatric subjects with NAFLD. Thus, the aims of the present narrative review are to analyze the current clinical evidence on the impact of MD in patients with NAFLD, and to summarize the main mechanisms of action of MD components on this condition.
C1 [Anania, Caterina; Perla, Francesco Massimo; Olivero, Francesca; Pacifico, Lucia] Sapienza Univ Rome, Policlin Umberto Hosp 1, I-00161 Rome, Italy.
   [Chiesa, Claudio] CNR, Inst Translat Pharmacol, Via Fosso del Cavaliere 100, I-00133 Rome, Italy.
C3 Sapienza University Rome; University Hospital Sapienza Rome; Consiglio
   Nazionale delle Ricerche (CNR); Istituto di Farmacologia Traslazionale
   (IFT-CNR)
RP Chiesa, C (corresponding author), CNR, Inst Translat Pharmacol, Via Fosso del Cavaliere 100, I-00133 Rome, Italy.
EM claudio.chiesa@ift.cnr.it
RI Pacifico, Lucia/S-4662-2019
OI ANANIA, Caterina/0000-0002-9607-8632
CR Abenavoli L, 2015, EXPERT REV GASTROENT, V9, P519, DOI 10.1586/17474124.2015.1004312
   Abu-Shanab A, 2010, NAT REV GASTRO HEPAT, V7, P691, DOI 10.1038/nrgastro.2010.172
   Aller R, 2015, NUTR HOSP, V32, P2518, DOI 10.3305/nh.2015.32.6.10074
   ANDERSEN T, 1991, J HEPATOL, V12, P224, DOI 10.1016/0168-8278(91)90942-5
   Angulo P, 2002, NEW ENGL J MED, V346, P1221, DOI 10.1038/nrdp.2015.80
   [Anonymous], 1980, 7 COUNTRIES MULTIVAR
   Arendt BM, 2015, HEPATOLOGY, V61, P1565, DOI 10.1002/hep.27695
   Asrih M, 2014, CLIN NUTR, V33, P186, DOI 10.1016/j.clnu.2013.11.003
   Bahcecioglu Ibrahim Halil, 2010, Vet Med Int, V2010, DOI 10.4061/2010/262179
   Baratta F, 2017, AM J GASTROENTEROL, V112, P1832, DOI 10.1038/ajg.2017.371
   Bashiardes S, 2016, MOL METAB, V5, P782, DOI 10.1016/j.molmet.2016.06.003
   Bozzetto L, 2012, DIABETES CARE, V35, P1429, DOI 10.2337/dc12-0033
   Buzzetti E, 2016, METABOLISM, V65, P1038, DOI 10.1016/j.metabol.2015.12.012
   Cakir M, 2016, CHILD OBES, V12, P279, DOI 10.1089/chi.2015.0197
   Chan R, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0139310
   Chen SH, 2015, DIGEST LIVER DIS, V47, P226, DOI 10.1016/j.dld.2014.11.015
   Clemente JC, 2012, CELL, V148, P1258, DOI 10.1016/j.cell.2012.01.035
   Clemente MG, 2016, WORLD J GASTROENTERO, V22, P8078, DOI 10.3748/wjg.v22.i36.8078
   David LA, 2014, NATURE, V505, P559, DOI 10.1038/nature12820
   Della Corte C, 2017, NUTRITION, V39-40, P8, DOI 10.1016/j.nut.2017.02.008
   Di Daniele N, 2017, ONCOTARGET, V8, P8947, DOI 10.18632/oncotarget.13553
   Di Martino M, 2016, WORLD J GASTROENTERO, V22, P8812, DOI 10.3748/wjg.v22.i39.8812
   Dumas ME, 2006, P NATL ACAD SCI USA, V103, P12511, DOI 10.1073/pnas.0601056103
   EASL, 2016, OBESITY FACTS, V9, P65, DOI [10.1159/000443344, 10.1007/s00125-016-3902-y, 10.1016/j.jhep.2015.11.004]
   Eliades M, 2015, WORLD J GASTROENTERO, V21, P1718, DOI 10.3748/wjg.v21.i6.1718
   Estruch R, 2013, NEW ENGL J MED, V368, P1279, DOI 10.1056/NEJMoa1200303
   Faghihzadeh F, 2014, NUTR RES, V34, P837, DOI 10.1016/j.nutres.2014.09.005
   Fraser A, 2008, DIABETOLOGIA, V51, P1616, DOI 10.1007/s00125-008-1049-1
   Fung TT, 2009, CIRCULATION, V119, P1093, DOI 10.1161/CIRCULATIONAHA.108.816736
   Garg A, 1998, AM J CLIN NUTR, V67, p577S, DOI 10.1093/ajcn/67.3.577S
   Gelli C, 2017, WORLD J GASTROENTERO, V23, P3150, DOI 10.3748/wjg.v23.i17.3150
   Godos J, 2017, INT J FOOD SCI NUTR, V68, P18, DOI 10.1080/09637486.2016.1214239
   Gómez-Hurtado I, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023037
   Harrison SA, 2003, AM J GASTROENTEROL, V98, P2485, DOI 10.1111/j.1572-0241.2003.08699.x
   Hasegawa T, 2001, ALIMENT PHARM THERAP, V15, P1667, DOI 10.1046/j.1365-2036.2001.01083.x
   Queipo-Ortuño MI, 2012, AM J CLIN NUTR, V95, P1323, DOI 10.3945/ajcn.111.027847
   JUMP DB, 1995, PROSTAG LEUKOTR ESS, V52, P107, DOI 10.1016/0952-3278(95)90007-1
   Kahn SE, 2006, NATURE, V444, P840, DOI 10.1038/nature05482
   Kastorini CM, 2011, J AM COLL CARDIOL, V57, P1299, DOI 10.1016/j.jacc.2010.09.073
   Kesse-Guyot E, 2013, NUTR METAB CARDIOVAS, V23, P677, DOI 10.1016/j.numecd.2012.02.005
   KEYS A, 1986, AM J EPIDEMIOL, V124, P903, DOI 10.1093/oxfordjournals.aje.a114480
   Keys Ancel, 1995, American Journal of Clinical Nutrition, V61, p1321S, DOI 10.1093/ajcn/61.6.1321S
   Kontogianni MD, 2014, CLIN NUTR, V33, P678, DOI 10.1016/j.clnu.2013.08.014
   Kotronen A, 2008, ARTERIOSCL THROM VAS, V28, P27, DOI 10.1161/ATVBAHA.107.147538
   Kumar R, 2017, J CLIN TRANSL HEPATO, V5, P216, DOI 10.14218/JCTH.2016.00068
   Lavine JE, 2000, J PEDIATR-US, V136, P734, DOI 10.1016/S0022-3476(00)05040-X
   Lazo M, 2013, AM J EPIDEMIOL, V178, P38, DOI 10.1093/aje/kws448
   Le Roy T, 2013, GUT, V62, P1787, DOI 10.1136/gutjnl-2012-303816
   Liu Y, 2014, AM J PHYSIOL-ENDOC M, V306, pE975, DOI 10.1152/ajpendo.00699.2013
   Lopez-Garcia E, 2014, AM J CLIN NUTR, V99, P172, DOI 10.3945/ajcn.113.068106
   Madan Kaushal, 2005, Indian J Gastroenterol, V24, P251
   Misciagna G, 2017, J NUTR HEALTH AGING, V21, P404, DOI 10.1007/s12603-016-0809-8
   Mitrou PN, 2007, ARCH INTERN MED, V167, P2461, DOI 10.1001/archinte.167.22.2461
   Monteiro J, 2014, FOOD FUNCT, V5, P426, DOI 10.1039/c3fo60551e
   Mouzaki M, 2013, HEPATOLOGY, V58, P120, DOI 10.1002/hep.26319
   Mouzaki M, 2012, J CLIN GASTROENTEROL, V46, P457, DOI 10.1097/MCG.0b013e31824cf51e
   Muegge BD, 2011, SCIENCE, V332, P970, DOI 10.1126/science.1198719
   Murillo Ana Gabriela, 2016, Biology-Basel, V5, P42, DOI 10.3390/biology5040042
   Nadal I, 2009, INT J OBESITY, V33, P758, DOI 10.1038/ijo.2008.260
   Pacifico L, 2007, ACTA PAEDIATR, V96, P542, DOI 10.1111/j.1651-2227.2007.00186.x
   Pacifico L, 2010, WORLD J HEPATOL, V2, P275, DOI 10.4254/wjh.v2.i7.275
   Pacifico L, 2011, WORLD J GASTROENTERO, V17, P3012, DOI 10.3748/wjg.v17.i25.3012
   Paniagua JA, 2007, J AM COLL NUTR, V26, P434, DOI 10.1080/07315724.2007.10719633
   Valdecantos MP, 2010, REDOX REP, V15, P207, DOI 10.1179/135100010X12826446921464
   Potter JJ, 2013, LIVER INT, V33, P677, DOI 10.1111/liv.12122
   Prates RE, 2016, DIABETES RES CLIN PR, V116, P205, DOI 10.1016/j.diabres.2016.03.019
   Promrat K, 2010, HEPATOLOGY, V51, P121, DOI 10.1002/hep.23276
   Reeder SB, 2011, J MAGN RESON IMAGING, V34, P729, DOI 10.1002/jmri.22580
   Richards JL, 2016, CLIN TRANSL IMMUNOL, V5, DOI 10.1038/cti.2016.29
   Rodriguez-Ramiro I, 2016, P NUTR SOC, V75, P47, DOI 10.1017/S0029665115004218
   Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012
   Salamone F, 2012, TRANSL RES, V159, P477, DOI 10.1016/j.trsl.2011.12.003
   Salomone F, 2016, LIVER INT, V36, P5, DOI 10.1111/liv.12975
   Scalbert Augustin, 2000, Journal of Nutrition, V130, p2073S
   Schröder H, 2007, J NUTR BIOCHEM, V18, P149, DOI 10.1016/j.jnutbio.2006.05.006
   Simopoulos AP, 2008, EXP BIOL MED, V233, P674, DOI 10.3181/0711-MR-311
   Sofi F, 2010, AM J CLIN NUTR, V92, P1189, DOI 10.3945/ajcn.2010.29673
   Sofi F, 2008, BMJ-BRIT MED J, V337, DOI 10.1136/bmj.a1344
   Stahl W, 2003, MOL ASPECTS MED, V24, P345, DOI 10.1016/S0098-2997(03)00030-X
   Theuwissen E, 2008, PHYSIOL BEHAV, V94, P285, DOI 10.1016/j.physbeh.2008.01.001
   Thoma C, 2012, J HEPATOL, V56, P255, DOI 10.1016/j.jhep.2011.06.010
   Tosti V, 2018, J GERONTOL A-BIOL, V73, P318, DOI 10.1093/gerona/glx227
   TRICHOPOULOU A, 1995, BMJ-BRIT MED J, V311, P1457, DOI 10.1136/bmj.311.7018.1457
   Trichopoulou A, 2003, NEW ENGL J MED, V348, P2599, DOI 10.1056/NEJMoa025039
   Trovato FM, 2016, WORLD J HEPATOL, V8, P1459, DOI 10.4254/wjh.v8.i33.1459
   Trovato FM, 2015, CLIN NUTR, V34, P86, DOI 10.1016/j.clnu.2014.01.018
   Van De Wier B, 2017, CRIT REV FOOD SCI, V57, P834, DOI 10.1080/10408398.2014.952399
   Vilar-Gomez E, 2015, GASTROENTEROLOGY, V149, P367, DOI 10.1053/j.gastro.2015.04.005
   Wong VWS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0062885
NR 89
TC 185
Z9 190
U1 1
U2 37
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD MAY 21
PY 2018
VL 24
IS 19
BP 2083
EP 2094
DI 10.3748/wjg.v24.i19.2083
PG 12
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA GG3MG
UT WOS:000432595300004
PM 29785077
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Gupta, N
   Goel, K
   Shah, P
   Misra, A
AF Gupta, Nidhi
   Goel, Kashish
   Shah, Priyali
   Misra, Anoop
TI Childhood Obesity in Developing Countries: Epidemiology, Determinants,
   and Prevention
SO ENDOCRINE REVIEWS
LA English
DT Review
ID ASIAN INDIAN ADOLESCENTS; C-REACTIVE PROTEIN; NUTRITION EXAMINATION
   SURVEY; IMPAIRED GLUCOSE-TOLERANCE; TYPE-2 DIABETES-MELLITUS;
   PRIMARY-SCHOOL CHILDREN; 3RD NATIONAL-HEALTH; BODY-MASS INDEX; METABOLIC
   SYNDROME; PHYSICAL-ACTIVITY
AB Rapidly changing dietary practices and a sedentary lifestyle have led to increasing prevalence of childhood obesity (5-19 yr) in developing countries recently: 41.8% in Mexico, 22.1% in Brazil, 22.0% in India, and 19.3% in Argentina. Moreover, secular trends indicate increasing prevalence rates in these countries: 4.1 to 13.9% in Brazil during 1974-1997, 12.2 to 15.6% in Thailand during 1991-1993, and 9.8 to 11.7% in India during 2006-2009. Important determinants of childhood obesity include high socioeconomic status, residence in metropolitan cities, female gender, unawareness and false beliefs about nutrition, marketing by transnational food companies, increasing academic stress, and poor facilities for physical activity. Childhood obesity has been associated with type 2 diabetes mellitus, the early-onset metabolic syndrome, subclinical inflammation, dyslipidemia, coronary artery diseases, and adulthood obesity. Therapeutic lifestyle changes and maintenance of regular physical activity through parental initiative and social support interventions are the most important strategies in managing childhood obesity. Also, high-risk screening and effective health educational programs are urgently needed in developing countries. (Endocrine Reviews 33: 48-70, 2012)
C1 [Gupta, Nidhi] Childrens Hosp Michigan, Dept Pediat, Detroit, MI 48201 USA.
   [Gupta, Nidhi] Mayo Clin, Coll Med, Endocrine Res Unit, Rochester, MN 55905 USA.
   [Goel, Kashish] Mayo Clin, Coll Med, Div Cardiovasc Dis, Rochester, MN 55905 USA.
   [Gupta, Nidhi; Goel, Kashish; Shah, Priyali; Misra, Anoop] Diabet Fdn India, New Delhi 110016, India.
   [Shah, Priyali; Misra, Anoop] Natl Diabet Obes & Cholesterol Disorders Fdn N DO, New Delhi 110016, India.
   [Goel, Kashish] Wayne State Univ, Dept Internal Med, Detroit, MI 48202 USA.
   [Misra, Anoop] Fortis Hosp, Fortis C DOC Ctr Excellence Diabet Metab Dis & En, New Delhi 110070, India.
C3 Children's Hospital of Michigan; Mayo Clinic; Mayo Clinic; Wayne State
   University
RP Misra, A (corresponding author), Fortis Flt Lt Rajan Dhall Hosp, Dept Diabet & Metab Dis, New Delhi 110070, India.
EM anoopmisra@metabolicresearchindia.com
RI Goel, Kashish/E-4916-2011; Shah (Pathak), Priyali/KOC-1951-2024
OI Shah (Pathak), Priyali/0000-0003-2806-6100; Gupta,
   Nidhi/0000-0001-6485-3318
FU National Diabetes, Obesity, and Cholesterol Disorders Foundation
   (N-DOC), NewDelhi; Diabetes Foundation (India); World Diabetes
   Foundation, Denmark
FX We acknowledge the support and cooperation of National Diabetes,
   Obesity, and Cholesterol Disorders Foundation (N-DOC), NewDelhi,
   Diabetes Foundation (India), and World Diabetes Foundation, Denmark in
   various research initiatives in childhood obesity undertaken by our
   group.
CR Agirbasli M, 2006, METABOLISM, V55, P1002, DOI 10.1016/j.metabol.2006.03.009
   Ahlsson F, 2007, ACTA PAEDIATR, V96, P358, DOI 10.1111/j.1651-2227.2006.00141.x
   Al Mamun A, 2009, OBESITY, V17, P1255, DOI 10.1038/oby.2008.660
   Al-Hazzaa HM, 2007, SAUDI MED J, V28, P766
   Allensworth D., 1997, Schools and Health: Our Nations Investment
   [Anonymous], 2006, WHO CHILD GROWTH STA
   [Anonymous], CAN MEX BATTL CHILDH
   [Anonymous], 1990, NUTR REQ REC DIET AL
   [Anonymous], IMF EM DEV EC LIST W
   [Anonymous], 21 NAT NUTR MON BUR
   [Anonymous], NUTR INT FOOD MEAN A
   [Anonymous], 24 NAT NUTR MON BUR
   [Anonymous], ISF HLTH HEART PROGR
   [Anonymous], OUR UNESDA COMM ACT
   [Anonymous], KIDS HLTH NEM HLTH E
   [Anonymous], J PUBLIC HLTH OXF
   [Anonymous], AM COLL SPORTS MED 5
   [Anonymous], FAT TRUTH FIGHT CHIL
   Armstrong MEG, 2006, SAMJ S AFR MED J, V96, P439
   ARMSTRONG N, 1990, BMJ-BRIT MED J, V301, P203, DOI 10.1136/bmj.301.6745.203
   Arya S, 2006, NUTRITION, V22, P865, DOI 10.1016/j.nut.2006.05.002
   Ayatollahi SMT, 2007, OBES REV, V8, P289, DOI 10.1111/j.1467-789X.2006.00299.x
   Bai P V, 1995, Indian Pediatr, V32, P1173
   Bajaj S, 2009, INDIAN J MED RES, V129, P285
   Bauman A, 2009, PREV MED, V49, P309, DOI 10.1016/j.ypmed.2009.07.017
   Bavdekar A, 1999, DIABETES, V48, P2422, DOI 10.2337/diabetes.48.12.2422
   Bhardwaj S, 2008, ASIA PAC J CLIN NUTR, V17, P172
   Bhargava SK, 2004, NEW ENGL J MED, V350, P865, DOI 10.1056/NEJMoa035698
   Biasillo Gina, 2009, Recenti Progressi in Medicina, V100, P279
   Biró L, 2007, ANN NUTR METAB, V51, P454, DOI 10.1159/000111166
   Brewis A, 2003, AM J HUM BIOL, V15, P446, DOI 10.1002/ajhb.10161
   Butte NF, 2007, J NUTR, V137, P153, DOI 10.1093/jn/137.1.153
   Caballero C, 2007, ARCH LATINOAM NUTR, V57, P231
   Caceres M, 2008, BMC PEDIATR, V8, DOI 10.1186/1471-2431-8-31
   Chadha DS, 2009, METAB SYNDR RELAT D, V7, P151, DOI 10.1089/met.2008.0054
   Chandalia M, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000812
   Chhatwal J, 2004, ASIA PAC J CLIN NUTR, V13, P231
   Chiolero A, 2009, CIRCULATION, V119, P558, DOI 10.1161/CIRCULATIONAHA.108.796276
   Cole TJ, 2000, BMJ-BRIT MED J, V320, P1240, DOI 10.1136/bmj.320.7244.1240
   Cook S, 2003, ARCH PEDIAT ADOL MED, V157, P821, DOI 10.1001/archpedi.157.8.821
   de Assis MAA, 2005, EUR J CLIN NUTR, V59, P1015, DOI 10.1038/sj.ejcn.1602206
   de Ferranti SD, 2004, CIRCULATION, V110, P2494, DOI 10.1161/01.CIR.0000145117.40114.C7
   de Onis M, 2000, AM J CLIN NUTR, V72, P1032
   de Onis M, 2010, AM J CLIN NUTR, V92, P1257, DOI 10.3945/ajcn.2010.29786
   Vasconcelos Vera Lucia de, 2003, Cad. Saúde Pública, V19, P1445, DOI 10.1590/S0102-311X2003000500023
   Discigil G, 2009, CHILD CARE HLTH DEV, V35, P153, DOI 10.1111/j.1365-2214.2008.00919.x
   Doak C, 2002, PUBLIC HEALTH NUTR, V5, P215, DOI 10.1079/PHN2001296
   Dunn Winston, 2008, Curr Gastroenterol Rep, V10, P67, DOI 10.1007/s11894-008-0011-1
   Ebbeling CB, 2002, LANCET, V360, P473, DOI 10.1016/S0140-6736(02)09678-2
   El-Hazmi MAF, 2002, ANN SAUDI MED, V22, P303, DOI 10.5144/0256-4947.2002.303
   Esmaillzadeh A, 2006, OBESITY, V14, P377, DOI 10.1038/oby.2006.50
   Faigenbaum AD, 2010, CURR SPORT MED REP, V9, P161, DOI 10.1249/JSR.0b013e3181de1214
   Fall CHD, 2008, DIABETES CARE, V31, P2349, DOI 10.2337/dc08-0911
   Fogelholm M, 1999, INT J OBESITY, V23, P1262, DOI 10.1038/sj.ijo.0801061
   Franzini L, 2009, AM J PUBLIC HEALTH, V99, P271, DOI 10.2105/AJPH.2007.128702
   Goel K, 2008, OBESITY, V16, P451, DOI 10.1038/oby.2007.55
   Goel K, 2010, HEART, V96, P579, DOI 10.1136/hrt.2009.183236
   Gordon-Larsen P, 2000, PEDIATRICS, V105, DOI 10.1542/peds.105.6.e83
   GORTMAKER SL, 1993, NEW ENGL J MED, V329, P1008, DOI 10.1056/NEJM199309303291406
   Goyal Ramesh K, 2010, J Assoc Physicians India, V58, P151
   Gupta DK, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017221
   Gupta N, 2010, J AM COLL NUTR, V29, P81, DOI 10.1080/07315724.2010.10719820
   Hassapidou M, 2009, HORM-INT J ENDOCRINO, V8, P53, DOI 10.14310/horm.2002.1222
   Henry CJK, 2004, AM J HUM BIOL, V16, P346, DOI 10.1002/ajhb.20022
   Holst-Schumacher I, 2009, FOOD NUTR BULL, V30, P161, DOI 10.1177/156482650903000208
   Jabre P, 2005, CHILD CARE HLTH DEV, V31, P159, DOI 10.1111/j.1365-2214.2004.00458.x
   Jafar TH, 2008, ARCH DIS CHILD, V93, P373, DOI 10.1136/adc.2007.125641
   James WPT, 1997, BMJ-BRIT MED J, V314, P1545, DOI 10.1136/bmj.314.7093.1545
   Jayatissa R, 2006, FOOD NUTR BULL, V27, P153, DOI 10.1177/156482650602700206
   Ji CY, 2009, INT J CARDIOL, V132, P1, DOI 10.1016/j.ijcard.2008.07.003
   Julia M, 2008, HORM RES, V69, P301, DOI 10.1159/000114862
   Juliana KB, 2008, REV MED CHILE, V136, P22, DOI /S0034-98872008000100003
   Kadiki OA, 1996, DIABETES RES CLIN PR, V32, P165, DOI 10.1016/0168-8227(96)01262-4
   Kapil Umesh, 2002, Indian Pediatr, V39, P449
   Kaur S, 2008, ASIA PAC J CLIN NUTR, V17, P592
   Kaushik JS, 2011, INDIAN PEDIATR, V48, P97, DOI 10.1007/s13312-011-0035-8
   Kelishadi R, 2003, PEDIATR INT, V45, P435, DOI 10.1046/j.1442-200X.2003.01738.x
   Kelishadi Roya, 2005, J. Pediatr. (Rio J.), V81, P447, DOI 10.2223/JPED.1418
   Key TJ, 1998, PUBLIC HEALTH NUTR, V1, P33, DOI 10.1079/PHN19980006
   Khadilkar V V, 2004, Indian Pediatr, V41, P857
   Kim HM, 2007, DIABETES RES CLIN PR, V75, P111, DOI 10.1016/j.diabres.2006.04.009
   Krishnaveni GV, 2005, DIABETES CARE, V28, P2919, DOI 10.2337/diacare.28.12.2919
   Kuczmarski R J, 2000, Adv Data, P1
   Kumar HNH, 2008, INDIAN PEDIATR, V45, P497
   Kuriyan R, 2007, NUTR J, V6, DOI 10.1186/1475-2891-6-25
   Lafta RK, 2005, ANN SAUDI MED, V25, P389, DOI 10.5144/0256-4947.2005.389
   Laxmaiah A, 2007, OBESITY, V15, P1384, DOI 10.1038/oby.2007.165
   Lee MS, 2007, ASIA PAC J CLIN NUTR, V16, P594
   Lee YS, 2009, ANN ACAD MED SINGAP, V38, P75
   Li Y, 2008, BRIT J NUTR, V99, P565, DOI 10.1017/S0007114507797064
   Li Y, 2008, OBES REV, V9, P82, DOI 10.1111/j.1467-789X.2007.00444.x
   Likitmasku S, 2003, J PEDIATR ENDOCR MET, V16, P71
   Littlejohn EE, 2007, J PEDIATR ENDOCR MET, V20, P41
   Matheson DM, 2004, AM J CLIN NUTR, V79, P1088
   Misra A, 2004, INT J OBESITY, V28, P1217, DOI 10.1038/sj.ijo.0802704
   Misra A, 2009, J Assoc Physicians India, V57, P163
   Misra A, 2008, J CLIN ENDOCR METAB, V93, pS9, DOI 10.1210/jc.2008-1595
   Misra A, 2008, DIABETES CARE, V31, P1282, DOI 10.2337/dc07-2316
   Misra A, 2011, ANN NUTR METAB, V58, P203, DOI 10.1159/000329431
   Mo-Suwan Ladda, 1993, Southeast Asian Journal of Tropical Medicine and Public Health, V24, P590
   Moayeri H, 2006, EUR J PEDIATR, V165, P489, DOI 10.1007/s00431-006-0101-8
   Ghazali SM, 2006, TROP BIOMED, V23, P148
   Monasta L, 2010, OBES REV, V11, P695, DOI 10.1111/j.1467-789X.2010.00735.x
   MONELLO LF, 1963, AM J CLIN NUTR, V13, P35, DOI 10.1093/ajcn/13.1.35
   Moodie M, 2009, INT J BEHAV NUTR PHY, V6, DOI 10.1186/1479-5868-6-63
   Moraes Suzana Alves de, 2006, Cad. Saúde Pública, V22, P1289, DOI 10.1590/S0102-311X2006000600018
   Mozaffari H, 2007, INDIAN J PEDIATR, V74, P265, DOI 10.1007/s12098-007-0041-y
   Murnan J, 2006, J SCHOOL HEALTH, V76, P502, DOI 10.1111/j.1746-1561.2006.00148.x
   Mvo Z, 1999, Curationis, V22, P27
   Nelson MC, 2009, J AM DIET ASSOC, V109, P281, DOI 10.1016/j.jada.2008.10.050
   Neutzling MB, 2000, INT J OBESITY, V24, P869, DOI 10.1038/sj.ijo.0801245
   Núñez-Rivas Hilda Patricia, 2003, Rev Panam Salud Publica, V13, P24, DOI 10.1590/S1020-49892003000100004
   Omigbodun OO, 2010, J BIOSOC SCI, V42, P653, DOI 10.1017/S0021932010000234
   Organization W.H, 1995, WHO TECH REP SER
   Oude Luttikhuis H, 2009, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001872.pub2
   Oulamara H, 2009, INT J PEDIATR OBES, V4, P411, DOI 10.3109/17477160802596163
   Pandey RM, 2009, METAB SYNDR RELAT D, V7, P133, DOI 10.1089/met.2008.0053
   Parsons TJ, 1999, INT J OBESITY, V23, pS1
   Pedrozo W, 2008, REV PANAM SALUD PUBL, V24, P149, DOI 10.1590/S1020-49892008000900001
   PETTITT DJ, 1991, DIABETES, V40, P126, DOI 10.2337/diab.40.2.S126
   Pituelli Suarez N, 2008, An Pediatr (Barc), V68, P257
   Popkin BM, 2002, PUBLIC HEALTH NUTR, V5, P93, DOI 10.1079/PHN200180
   Popkin BM, 2001, J NUTR, V131, p871S, DOI 10.1093/jn/131.3.871S
   Premanath M, 2010, INDIAN PEDIATR, V47, P171, DOI 10.1007/s13312-010-0027-0
   Raj M, 2007, NATL MED J INDIA, V20, P288
   Raj M, 2009, NUTR J, V8, DOI 10.1186/1475-2891-8-55
   Ramachandran A, 2002, DIABETES RES CLIN PR, V57, P185, DOI 10.1016/S0168-8227(02)00056-6
   Rao S, 2007, EUR J CLIN NUTR, V61, P633, DOI 10.1038/sj.ejcn.1602555
   Rerksuppaphol Sanguansak, 2010, J Med Assoc Thai, V93 Suppl 2, pS27
   Sabaté J, 2010, AM J CLIN NUTR, V91, p1525S, DOI 10.3945/ajcn.2010.28701F
   Sachdev HS, 2005, AM J CLIN NUTR, V82, P456, DOI 10.1093/ajcn/82.2.456
   Salazar-Martinez E, 2006, ARCH MED RES, V37, P535, DOI 10.1016/j.arcmed.2005.10.014
   Sallis JF, 2006, FUTURE CHILD, V16, P89, DOI 10.1353/foc.2006.0009
   Shah P, 2010, BRIT J NUTR, V104, P427, DOI 10.1017/S0007114510000681
   Shaibi GQ, 2006, MED SCI SPORT EXER, V38, P1208, DOI 10.1249/01.mss.0000227304.88406.0f
   Sharma A, 2007, PUBLIC HEALTH NUTR, V10, P485, DOI 10.1017/S1368980007223894
   Singhal N, 2010, EUR J CLIN NUTR, V64, P364, DOI 10.1038/ejcn.2009.150
   Story M, 2006, FUTURE CHILD, V16, P109, DOI 10.1353/foc.2006.0007
   Story M, 1996, J AM DIET ASSOC, V96, P123, DOI 10.1016/S0002-8223(96)00039-9
   STUNKARD A, 1967, AM J PSYCHIAT, V123, P1443, DOI 10.1176/ajp.123.11.1443
   Tee E Jr, 1999, Malays J Nutr, V5, P87
   Tee E-Siong, 2002, Food and Nutrition Bulletin, V23, P41
   Tfaylio H, 2008, ANN NY ACAD SCI, V1135, P85, DOI 10.1196/annals.1429.024
   Usfar AA, 2010, OBES REV, V11, P924, DOI 10.1111/j.1467-789X.2010.00814.x
   Vikram NK, 2009, ASIA PAC J CLIN NUTR, V18, P293
   Vikram NK, 2006, ATHEROSCLEROSIS, V186, P193, DOI 10.1016/j.atherosclerosis.2005.07.015
   Vikram NK, 2006, DIABETIC MED, V23, P293, DOI 10.1111/j.1464-5491.2005.01782.x
   Vikram NK, 2003, ATHEROSCLEROSIS, V168, P305, DOI 10.1016/S0021-9150(03)00096-0
   Wang Y, 2009, OBES REV, V10, P456, DOI 10.1111/j.1467-789X.2009.00568.x
   Wang YF, 2002, AM J CLIN NUTR, V75, P971, DOI 10.1093/ajcn/75.6.971
   Wardle J, 2006, BRIT MED J, V332, P1130, DOI 10.1136/bmj.38807.594792.AE
   Wasir JS, 2004, METAB SYNDR RELAT D, V2, P14, DOI 10.1089/met.2004.2.14
   Wickramasinghe V. P., 2004, Ceylon Medical Journal, V49, P114
   Wijeyaratne CN, 2002, CLIN ENDOCRINOL, V57, P343, DOI 10.1046/j.1365-2265.2002.01603.x
   World Health Organization, 2006, WHO Child Growth Standards: Length/height-for-age, weight-for-age, weight-for-length, weight-for-height and body mass index-for-age: Methods and development
   Wu SY, 2011, AM J PREV MED, V40, P149, DOI 10.1016/j.amepre.2010.10.029
   Yajnik CS, 2002, J CLIN ENDOCR METAB, V87, P5575, DOI 10.1210/jc.2002-020434
   Yilmaz FM, 2007, J PEDIATR ENDOCR MET, V20, P205
   Zargar A H, 2001, J Postgrad Med, V47, P27
   Zimmet P, 2007, PEDIATR DIABETES, V8, P299, DOI 10.1111/j.1399-5448.2007.00271.x
NR 160
TC 414
Z9 483
U1 1
U2 180
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0163-769X
EI 1945-7189
J9 ENDOCR REV
JI Endocr. Rev.
PD FEB
PY 2012
VL 33
IS 1
BP 48
EP 70
DI 10.1210/er.2010-0028
PG 23
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA 894CH
UT WOS:000300404100002
PM 22240243
DA 2025-06-11
ER

PT J
AU Chang, TI
   Tanner, JM
   Harada, ND
   Garrett, NR
   Friedlander, AH
AF Chang, Tina I.
   Tanner, Jeffrey M.
   Harada, Nancy D.
   Garrett, Neal R.
   Friedlander, Arthur H.
TI Prevalence of calcified carotid artery atheromas on the panoramic images
   of patients with syndrome Z, coexisting obstructive sleep apnea, and
   metabolic syndrome
SO ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
LA English
DT Article
ID INSULIN-RESISTANCE; RISK-FACTORS; CARDIOVASCULAR-DISEASE; INTERMITTENT
   HYPOXIA; OXIDATIVE STRESS; ATHEROSCLEROSIS; COMPLICATIONS; INFLAMMATION;
   ASSOCIATION; POPULATION
AB Objectives. The objective of this study was to compare the prevalence of calcified carotid artery atheromas (CCAAs) on panoramic images of individuals (n = 31) with obstructive sleep apnea (OSA) with individuals (n = 117) with syndrome Z (SZ: OSA with concomitant metabolic syndrome [MetS]).
   Study design. Images of patients with OSA or SZ referred from the Sleep Service to Dentistry were evaluated. Descriptive statistics and t tests (Bonferroni correction) were conducted to determine significant differences between atheroma prevalence and proatherogenic factors (age, apnea-hypopnea index, body mass index, lipid profile, blood pressure, glucose) between OSA and SZ groups.
   Results. Individuals with OSA had an atheroma prevalence of 35% and those with SZ 42% (P = .52). Individuals with SZ also had significantly more severe atherogenic profiles (obesity, dyslipidemia, hyperglycemia) than OSA patients (P <= .05). Greatest CCAA prevalence (63%) was evidenced by SZ patients with severe OSA and moderate MetS.
   Conclusion. Individuals with SZ have significantly greater atherogenic burden and slightly higher prevalence of CCAAs when compared with individuals with OSA. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;113:134-141)
C1 [Tanner, Jeffrey M.; Friedlander, Arthur H.] VA Greater Los Angeles Healthcare Syst, Dent Serv, Oral & Maxillofacial Surg Sect, Los Angeles, CA 90073 USA.
   [Harada, Nancy D.] Vet Affairs Greater Los Angeles Healthcare Syst, Geriatr Res Educ & Clin Ctr, Los Angeles, CA 90073 USA.
   [Garrett, Neal R.] Univ Calif Los Angeles, Sch Dent, Div Adv Prosthodont Biomat & Hosp Dent, Los Angeles, CA 90024 USA.
   [Harada, Nancy D.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.
   [Friedlander, Arthur H.] Ronald Reagan UCLA Med Ctr, Hosp Dent Serv, Torrance, CA USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA Greater Los Angeles Healthcare System; Geriatric Research Education &
   Clinical Center; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Greater Los Angeles Healthcare System;
   University of California System; University of California Los Angeles;
   University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA; University of California System; University of
   California Los Angeles; University of California Los Angeles Medical
   Center; Ronald Reagan UCLA Medical Center
RP Friedlander, AH (corresponding author), VA Greater Los Angeles Healthcare Syst, Dent Serv, Oral & Maxillofacial Surg Sect, 11301 Wilshire Blvd, Los Angeles, CA 90073 USA.
EM arthur.friedlander@va.gov
FU Department of Veterans Affairs; University of California; National
   Center for Research Resources, National Institutes of Health [C06
   RR-14529-01]
FX The financial support of this project was limited to the full-time
   salaries paid to the authors by the Department of Veterans Affairs and
   the University of California. Elements of this investigation were
   conducted in a facility constructed with support from Research
   Facilities Improvement Program Grant Number C06 RR-14529-01 from the
   National Center for Research Resources, National Institutes of Health.
CR Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   American Academy of Sleep Medicine, 2007, AASM MAN SCOR SLEEP, P1
   Aurora RN, 2010, SLEEP, V33, P1408, DOI 10.1093/sleep/33.10.1408
   Belcaro G, 2001, ATHEROSCLEROSIS, V156, P379, DOI 10.1016/S0021-9150(00)00665-1
   Berglund L, 2003, ARTERIOSCL THROM VAS, V23, P1314, DOI 10.1161/01.ATV.0000087145.71160.15
   Butt M, 2010, INT J CARDIOL, V139, P7, DOI 10.1016/j.ijcard.2009.05.021
   Capampangan DJ, 2010, NEUROLOGIST, V16, P269, DOI 10.1097/NRL.0b013e3181e5a66c
   Carter LC, 1997, J AM DENT ASSOC, V128, P977, DOI 10.14219/jada.archive.1997.0338
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Coughlin SR, 2004, EUR HEART J, V25, P735, DOI 10.1016/j.ehj.2004.02.021
   Drager LF, 2010, ATHEROSCLEROSIS, V208, P490, DOI 10.1016/j.atherosclerosis.2009.08.016
   Einhorn Daniel, 2003, Endocr Pract, V9, P237
   Fisher EA, 2002, J BIOL CHEM, V277, P17377, DOI 10.1074/jbc.R100068200
   Ford ES, 2005, DIABETES CARE, V28, P2745, DOI 10.2337/diacare.28.11.2745
   Friedlander A H, 1995, Spec Care Dentist, V15, P223, DOI 10.1111/j.1754-4505.1995.tb00522.x
   Friedlander AH, 1999, J ORAL MAXIL SURG, V57, P516, DOI 10.1016/S0278-2391(99)90065-4
   Friedlander AH, 2005, J AM DENT ASSOC, V136, P635, DOI 10.14219/jada.archive.2005.0235
   Friedlander AH, 2007, ORAL SURG ORAL MED O, V103, P830, DOI 10.1016/j.tripleo.2006.07.016
   Ginsberg HN, 2003, AM J CARDIOL, V91, p29E, DOI 10.1016/S0002-9149(02)03386-6
   Gonzalez-Martin MC, 2009, ADV EXP MED BIOL, V648, P319, DOI 10.1007/978-90-481-2259-2_36
   Griniatsos J, 2009, ORAL SURG ORAL MED O, V108, P600, DOI 10.1016/j.tripleo.2009.03.041
   Grundy SM, 2004, ARTERIOSCL THROM VAS, V24, pE13, DOI 10.1161/01.ATV.0000111245.75752.C6
   Hulthe J, 2000, ARTERIOSCL THROM VAS, V20, P2140, DOI 10.1161/01.ATV.20.9.2140
   Isomaa B, 2003, LIFE SCI, V73, P2395, DOI 10.1016/S0024-3205(03)00646-5
   Johnsen SH, 2007, STROKE, V38, P2873, DOI 10.1161/STROKEAHA.107.487264
   Kannel W B, 2000, J Atheroscler Thromb, V6, P60
   Kato M, 2000, CIRCULATION, V102, P2607
   Lam Jamie C M, 2009, Expert Rev Respir Med, V3, P177, DOI 10.1586/ers.09.10
   Lattimore JDL, 2005, ATHEROSCLEROSIS, V179, P255, DOI 10.1016/j.atherosclerosis.2004.11.010
   Lavie L, 2009, EUR RESPIR J, V33, P1467, DOI 10.1183/09031936.00086608
   Lévy P, 2009, PROG CARDIOVASC DIS, V51, P400, DOI 10.1016/j.pcad.2008.03.001
   Lewis D. Andrew, 1999, General Dentistry, V47, P98
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   McFarlane SI, 2001, J CLIN ENDOCR METAB, V86, P713, DOI 10.1210/jc.86.2.713
   McLaughlin T, 2003, ANN INTERN MED, V139, P802, DOI 10.7326/0003-4819-139-10-200311180-00007
   Nock NL, 2009, SLEEP, V32, P615, DOI 10.1093/sleep/32.5.615
   Nossen J, 2001, HERZ, V26, P454, DOI 10.1007/PL00002048
   Peker Y, 2006, EUR RESPIR J, V28, P596, DOI 10.1183/09031936.06.00107805
   Peng YJ, 2003, ADV EXP MED BIOL, V536, P559
   Prabhakaran Shyam, 2007, Atherosclerosis, V195, pe197, DOI 10.1016/j.atherosclerosis.2007.03.044
   Punjabi NM, 2003, RESP PHYSIOL NEUROBI, V136, P167, DOI 10.1016/S1569-9048(03)00079-X
   Quercioli A, 2010, SLEEP BREATH, V14, P261, DOI 10.1007/s11325-010-0338-3
   Roger VL, 2011, CIRCULATION, V123, pE18, DOI 10.1161/CIR.0b013e3182009701
   Rouwet EV, 2002, CIRCULATION, V105, P2791, DOI 10.1161/01.CIR.0000017497.47084.06
   Ryan S, 2009, THORAX, V64, P631, DOI 10.1136/thx.2008.105577
   Ryan Silke, 2009, Cardiovascular & Hematological Agents in Medicinal Chemistry, V7, P76
   SALONEN JT, 1991, ARTERIOSCLER THROMB, V11, P1245, DOI 10.1161/01.ATV.11.5.1245
   Schulz R, 2005, EUR RESPIR J, V25, P69, DOI 10.1183/09031936.04.00030004
   Solymoss BC, 2004, AM J CARDIOL, V93, P159, DOI 10.1016/j.amjcard.2003.09.032
   Sorajja D, 2008, CHEST, V133, P927, DOI 10.1378/chest.07-2544
   Sowers JR, 2004, MED CLIN N AM, V88, P63, DOI 10.1016/S0025-7125(03)00128-7
   Tooke JE, 2000, J INTERN MED, V247, P425, DOI 10.1046/j.1365-2796.2000.00671.x
   Tripathy D, 2003, DIABETES, V52, P2882, DOI 10.2337/diabetes.52.12.2882
   Tsuda H, 2010, SLEEP BREATH, V14, P365, DOI 10.1007/s11325-009-0324-9
   Turmel J, 2009, INT J CARDIOL, V132, P203, DOI 10.1016/j.ijcard.2007.11.063
   Whittle AT, 1997, THORAX, V52, P1068, DOI 10.1136/thx.52.12.1068
   Wilcox I, 1998, THORAX, V53, pS25
   Young T, 2002, AM J RESP CRIT CARE, V165, P1217, DOI 10.1164/rccm.2109080
   YOUNG T, 1993, NEW ENGL J MED, V328, P1230, DOI 10.1056/NEJM199304293281704
NR 59
TC 4
Z9 5
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2212-4403
EI 1528-395X
J9 OR SURG OR MED OR PA
JI Oral Surg. Oral Med. Oral Pathol. Oral Radiol.
PD JAN
PY 2012
VL 113
IS 1
BP 134
EP 141
DI 10.1016/j.tripleo.2011.07.039
PG 8
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA 898ZW
UT WOS:000300781900016
PM 22669072
OA Bronze
DA 2025-06-11
ER

PT J
AU Cheung, G
   Gee, S
   Jamieson, H
   Berger, U
AF Cheung, Gary
   Gee, Susan
   Jamieson, Hamish
   Berger, Ulrich
TI What Is Frailty? Perspectives from Chinese Clinicians and Older
   Immigrants in New Zealand
SO JOURNAL OF CROSS-CULTURAL GERONTOLOGY
LA English
DT Article
DE Ethnicity; Frailty; Health professionals; Older people; Overseas Chinese
ID METABOLIC SYNDROME; ADULTS; PREVALENCE; DEPRESSION; PEOPLE; RISK
AB This qualitative study explores the meanings of frailty held by Chinese New Zealanders and Chinese health care professionals with the aim of identifying commonalities as well as potential differences. Two guided focus groups with Mandarin and Cantonese speaking older adults (n = 10), one individual interview with a English speaking older Chinese, and one focus group with Chinese New Zealand health care professionals (n = 7) were held to obtain views on frailty in older adults, followed by transcribing and a thematic qualitative analysis. Three main themes emerged: (1) Frailty is marked by ill-health, multiple chronic and unstable medical comorbidities, and is a linked with polypharmacy; (2) Frailty can involve physical weakness, decline in physical function such as reduced mobility or poor balance, and declining cognitive function; and (3) Frailty is associated with psychological and social health including depression, reduced motivation, social isolation, and loss of confidence. The perspectives of frailty that emerged are congruent with a multi-dimensional concept of frailty that has been described in both Chinese and non-Chinese medical research literature.
C1 [Cheung, Gary] Univ Auckland, Dept Psychol Med, Auckland Mail Ctr, Private Bag 92019, Auckland 1142, New Zealand.
   [Gee, Susan; Jamieson, Hamish; Berger, Ulrich] Univ Otago, Christchurch, New Zealand.
   [Gee, Susan; Jamieson, Hamish] Canterbury Dist Hlth Board, Christchurch, New Zealand.
C3 University of Auckland; University of Otago
RP Cheung, G (corresponding author), Univ Auckland, Dept Psychol Med, Auckland Mail Ctr, Private Bag 92019, Auckland 1142, New Zealand.
EM g.cheung@auckland.ac.nz
OI jamieson, hamishj/0000-0002-2462-1595; Bergler, Hans/0000-0002-6478-8541
FU Older People Mental Health Services Research Trust, Canterbury District
   Health Board, New Zealand [6409313.4920.00000]
FX This study was funded by the Older People Mental Health Services
   Research Trust, Canterbury District Health Board, New Zealand (grant
   number 6409313.4920.00000).
CR [Anonymous], 2014, 2013 Census: Ethnic Group (Total Responses) by Age Group and Sex
   [Anonymous], This review highlights the importance of finding best biomarker for frailty
   Bergman H, 2007, J GERONTOL A-BIOL, V62, P731, DOI 10.1093/gerona/62.7.731
   BPAC, 2010, BEST PRACTICE J, V27, P8
   BPAC, 2010, BEST PRACTICE J, V27, P10
   Braun V., 2006, Qual. Res. Psychol., V3, P77, DOI [10.1191/1478088706qp063oa, DOI 10.1191/1478088706QP063OA, DOI 10.1080/10875549.2021.1929659]
   Brooker D., 2015, PERSON CENTRED DEMEN
   Chan DC, 2010, ARCH GERONTOL GERIAT, V50, pE74, DOI 10.1016/j.archger.2009.06.004
   Chang CI, 2011, J FORMOS MED ASSOC, V110, P247, DOI 10.1016/S0929-6646(11)60037-5
   Cheung G, 2017, AUSTRALAS PSYCHIATRY, V25, P543, DOI 10.1177/1039856217739730
   Clegg A, 2013, LANCET, V381, P752, DOI 10.1016/S0140-6736(12)62167-9
   Collerton J, 2012, MECH AGEING DEV, V133, P456, DOI 10.1016/j.mad.2012.05.005
   Dury S, 2018, BMC PUBLIC HEALTH, V18, DOI 10.1186/s12889-018-5088-3
   Fried LP, 2001, J GERONTOL A-BIOL, V56, pM146, DOI 10.1093/gerona/56.3.M146
   Gee S.B., NZ MEDICAL JOUNRAL
   Gee SB., 2002, HALLYM INT J AGING, V4, P45, DOI [10.2190/GRK5-6NA8-E1CF-H1F8, DOI 10.2190/GRK5-6NA8-E1CF-H1F8]
   Gee SB, 2019, J AGING RES, V2019, DOI 10.1155/2019/2573239
   Hao Q, 2016, J NUTR HEALTH AGING, V20, P82, DOI [10.1007/s12603-016-0680-7, 10.1007/s12603-015-0553-5]
   He B, 2019, J NUTR HEALTH AGING, V23, P442, DOI 10.1007/s12603-019-1179-9
   Heiniger LE, 2015, J IMMIGR MINOR HEALT, V17, P165, DOI 10.1007/s10903-013-9922-5
   Ho Elsie., 2015, New Zealand Population Review, V41, P95, DOI DOI 10.1016/S0140-6736(00)71699-0
   Hong TB, 2004, J GERONTOL B-PSYCHOL, V59, pP151, DOI 10.1093/geronb/59.4.P151
   Immigration New Zealand, 2018, SUBNATIONAL ETHNIC P
   Kalyani RR, 2012, J NUTR HEALTH AGING, V16, P679, DOI [10.1007/s12603-012-0369-5, 10.1007/s12603-012-0066-4]
   Lau BHP, 2016, AM J GERIAT PSYCHIAT, V24, P753, DOI 10.1016/j.jagp.2016.05.014
   Li YX, 2019, NEUROL RES, V41, P728, DOI 10.1080/01616412.2019.1609164
   Liu CL, 2013, J NUTR HEALTH AGING, V17, P523, DOI 10.1007/s12603-013-0010-2
   Ma LN, 2020, J HYPERTENS, V38, P2192, DOI 10.1097/HJH.0000000000002650
   Malmstrom TK, 2013, J NUTR HEALTH AGING, V17, P723, DOI 10.1007/s12603-013-0395-y
   Markle-Reid M, 2003, J ADV NURS, V44, P58, DOI 10.1046/j.1365-2648.2003.02767.x
   Mello AD, 2014, CAD SAUDE PUBLICA, V30, P1143, DOI 10.1590/0102-311X00148213
   Morley JE, 2012, J NUTR HEALTH AGING, V16, P601, DOI 10.1007/s12603-012-0084-2
   Ng TP, 2014, J AM MED DIR ASSOC, V15, P635, DOI 10.1016/j.jamda.2014.03.008
   Poston DudleyL., 2016, CHINESE J SOCIOL, DOI DOI 10.1177/2057150X16655077
   Puts MTE, 2009, J AGING STUD, V23, P258, DOI 10.1016/j.jaging.2008.03.002
   Rockwood K, 2005, CAN MED ASSOC J, V173, P489, DOI 10.1503/cmaj.050051
   Senior HEJ, 2014, AGE AGEING, V43, P418, DOI 10.1093/ageing/afu025
   Sha S, 2020, BMC GERIATR, V20, DOI 10.1186/s12877-020-01714-5
   Sluka NA, 2018, BALT REG, V10, P80, DOI 10.5922/2079-8555-2018-3-5
   Tang Z, 2013, AGE AGEING, V42, P346, DOI 10.1093/ageing/aft004
   TAYLOR SE, 1988, PSYCHOL BULL, V103, P193, DOI 10.1037/0033-2909.103.2.193
   Teo N, 2019, BMC GERIATR, V19, DOI 10.1186/s12877-019-1367-9
   [田鹏 Tian Peng], 2019, [中国循证医学杂志, Chinese Journal of Evidence-Based Medicine], V19, P656
   Tian XY, 2018, PAIN, V159, P306, DOI 10.1097/j.pain.0000000000001105
   Woo J, 2005, GERONTOLOGY, V51, P402, DOI 10.1159/000088705
   Woo J, 2015, BMC GERIATR, V15, DOI 10.1186/s12877-015-0160-7
   Wu CK, 2018, J GERONTOL A-BIOL, V73, P102, DOI 10.1093/gerona/glx098
   Ye B, 2020, BMC GERIATR, V20, DOI 10.1186/s12877-020-01530-x
   Ye B, 2018, BMC GERIATR, V18, DOI 10.1186/s12877-018-0982-1
   Zhang N, 2020, AGING CLIN EXP RES, V32, P2297, DOI 10.1007/s40520-019-01409-x
   Zhang Qu-an, 2020, BMC Geriatrics, V20, DOI 10.1186/s12877-020-01798-z
NR 51
TC 6
Z9 6
U1 0
U2 11
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0169-3816
EI 1573-0719
J9 J CROSS-CULT GERONTO
JI J. Cross-Cult. Gerontol.
PD JUN
PY 2021
VL 36
IS 2
BP 201
EP 213
DI 10.1007/s10823-021-09424-0
EA APR 2021
PG 13
WC Gerontology
WE Emerging Sources Citation Index (ESCI)
SC Geriatrics & Gerontology
GA SS1EY
UT WOS:000638123800001
PM 33830425
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Torfadottir, JE
   Ulven, SM
AF Torfadottir, Johanna E.
   Ulven, Stine M.
TI Fish - a scoping review for Nordic Nutrition Recommendations 2023
SO FOOD & NUTRITION RESEARCH
LA English
DT Review
DE fish; seafood; polyunsaturatedfatty acids; dietary recommendations
ID CANCER RISK; FOOD GROUPS; CONSUMPTION; METAANALYSIS;
   OMEGA-3-FATTY-ACIDS; ASSOCIATION; ACID
AB The aim of this scoping review was to conduct evidence-based documentation between fish intake and health outcomes for food-based dietary guidelines (FBDGs) in the Nordic Nutrition Recommendations (NNR) 2023. For most health outcomes, the evidence for fish oil and n-3 long chain (LC) polyunsaturated fatty acids (PUFA) supplementation was included when examining evidence between fish intake and health. In this review, conclusions from qualified systematic reviews (qSR) approved by NNR2023 are included. In addition, conclusions of a de novo systematic reviews on the topic of n-3 LC-PUFA, asthma, and allergy are included. Finally, a systematic literature search was performed limited to systematic reviews and meta-analysis published between 2011 and September 2021. In total, 21 papers from the systematic literature search, four qSR, and eight reports were included addressing the association between fish intake, fish oil, and n-3 LC-PUFA supplementation on several health outcomes. These included cardiovascular disease (CVD), type 2 diabetes, cancers (colorectal, breast, and prostate), metabolic syndrome, obesity, mortality, cognition and mental health, pregnancy-related outcomes (preterm birth and birth weight), and outcomes specific for children (neurodevelopment, and risk of food allergies, and asthma). In addition, intermediate risk factors such as blood lipids, glucose, C -reactive protein, and blood pressure were reviewed. Based on current evidence, fish consumption can have beneficial effects to prevent coronary heart disease (CHD) and stroke incidence, and lower mortality from CVD, CHD, myocardial infarction (MI), and stroke, as well as total mortality risk. In addition, fish consumption is beneficial for preventing cognitive decline in adults (e.g. dementia and Alzheimer's disease). Fish intake may also prevent metabolic syndrome, supported by an observed association between fish intake and reduction in plasma triglycerides and increase in high-density lipoprotein (HDL) cholesterol levels. Data from fish oil and n-3 LC-PUFA supplementation studies supports the conclusions on the effects of fish consumption on most of the health outcomes.
C1 [Torfadottir, Johanna E.] Univ Iceland, Ctr Publ Hlth Sci, Reykjavik, Iceland.
   [Torfadottir, Johanna E.] Directorate Hlth, Reykjavik, Iceland.
   [Ulven, Stine M.] Univ Oslo, Dept Nutr, Oslo, Norway.
   [Torfadottir, Johanna E.] Univ Iceland, Directorate Hlth, Reykjavik, Iceland.
C3 University of Iceland; University of Oslo; University of Iceland
RP Torfadottir, JE (corresponding author), Univ Iceland, Directorate Hlth, Reykjavik, Iceland.
EM jet@hi.is
RI Ulven, Stine/ABD-7140-2020
CR 2020 Dietary Guidelines Advisory Committee and Nutrition Evidence Systematic Review Team, 2020, Seafood consumption during pregnancy and lactation and neurocognitive development in the child: a systematic review. 2020 Dietary Guidelines Advisory Committee Project
   Aakre I, 2019, FOOD NUTR RES, V63, DOI 10.29219/fnr.v63.3573
   Abdelhamid AS, 2020, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD003177.pub5
   Alhassan A, 2017, ATHEROSCLEROSIS, V266, P87, DOI 10.1016/j.atherosclerosis.2017.09.028
   Andersen LF, 2022, Benefit and risk assessment of fish in the Norwegian diet - Scientific Opinion of the Steering Committee of the Norwegian Scientific Committee for Food and Environment. Benefit and risk assessment of fish in the Norwegian diet - Scientific Opinion of the Steering Committee of the Norwegian Scientific Committee for Food and Environment
   [Anonymous], 2018, Meat, fish and dairy products and the risk of cancer
   [Anonymous], 2022, Food-based dietary guidelines
   Arnesen EK, 2020, FOOD NUTR RES, V64, DOI 10.29219/fnr.v64.4404
   Arnesen EK, 2020, FOOD NUTR RES, V64, DOI 10.29219/fnr.v64.4403
   Aucoin M, 2017, INTEGR CANCER THER, V16, P32, DOI 10.1177/1534735416656052
   Balk EM, 2016, Evidence Report/Technology Assessment No. 223
   Barebring L, 2022, FOOD NUTR RES, V66, DOI 10.29219/fnr.v66.8842
   Blomhoff R., 2023, Nordic Nutrition Recommendations 2023: Integrating Environmental Aspects
   Brainard JS, 2020, J AM MED DIR ASSOC, V21, P1439, DOI 10.1016/j.jamda.2020.02.022
   Calder PC, 2017, BIOCHEM SOC T, V45, P1105, DOI 10.1042/BST20160474
   Campbell F, 2013, EUR J PREV CARDIOL, V20, P107, DOI 10.1177/2047487312437056
   Christensen JJ, 2020, FOOD NUTR RES, V64, DOI 10.29219/fnr.v64.4402
   Dale HF, 2019, NUTR REV, V77, P572, DOI 10.1093/nutrit/nuz016
   Deckelbaum RJ, 2006, AM J CLIN NUTR, V83, p1520S, DOI 10.1093/ajcn/83.6.1520S
   Dietary Guidelines Advisory Committee and Nutrition Evidence Systematic Review Team, 2020, Seafood consumption during childhood and adolescence and neurocognitive development: a systematic review. 2020 Dietary Guidelines Advisory Committee Project
   Donovan S, 2021, J Nutr, V151, P3483
   Du SC, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0142652
   Gao C, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-01214-w
   Gao HQ, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0528-0
   Garcia-Larsen V, 2018, PLOS MED, V15, DOI 10.1371/journal.pmed.1002507
   Grant R, 2016, ADV NEUROBIOL, V12, P247, DOI 10.1007/978-3-319-28383-8_13
   Grosso G, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/313570
   Hoyer A, 2021, FOOD NUTR RES, V65, DOI 10.29219/fnr.v65.7828
   Jazayeri S, 2020, COMPLEMENT THER MED, V53, DOI 10.1016/j.ctim.2020.102487
   Karimi G, 2020, NUTR METAB CARDIOVAS, V30, P717, DOI 10.1016/j.numecd.2020.02.001
   Kazemi A, 2021, ADV NUTR, V12, P809, DOI 10.1093/advances/nmaa147
   Kim YS, 2015, NUTRIENTS, V7, P2085, DOI 10.3390/nu7042085
   Lemming EW, 2022, FOOD NUTR RES, V66, DOI 10.29219/fnr.v66.8572
   Lichtenstein AH, 2021, CIRCULATION, V144, pE472, DOI 10.1161/CIR.0000000000001031
   Lin N, 2016, LIPIDS HEALTH DIS, V15, DOI 10.1186/s12944-016-0303-7
   Lovegrove C, 2015, INT J CLIN PRACT, V69, P87, DOI 10.1111/ijcp.12514
   Miller PE, 2014, AM J HYPERTENS, V27, P885, DOI 10.1093/ajh/hpu024
   Newberry SJ, 2016, Evidence Report/ Technology Assessment No. 224.
   Nordic Council of Ministers, 2014, Nordic Nutrition Recommendations 2012: Integrating Nutrition and Physical Activity
   Nwaru BI, 2022, FOOD NUTR RES, V66, DOI 10.29219/fnr.v66.8629
   Patrick RP, 2015, FASEB J, V29, P2207, DOI 10.1096/fj.14-268342
   Rimm EB, 2018, CIRCULATION, V138, pE35, DOI [10.1161/cir.0000000000000574, 10.1161/CIR.0000000000000574]
   Schwingshackl L, 2018, INT J CANCER, V142, P1748, DOI 10.1002/ijc.31198
   Schwingshackl L, 2017, ADV NUTR, V8, P793, DOI 10.3945/an.117.017178
   Vieira AR, 2017, ANN ONCOL, V28, P1788, DOI 10.1093/annonc/mdx171
   Wu J, 2016, NUTRIENTS, V8, DOI 10.3390/nu8110730
   Wu SJ, 2012, AM J MED, V125, P551, DOI 10.1016/j.amjmed.2012.01.022
   Yang B, 2016, NUTRIENTS, V8, DOI 10.3390/nu8010058
   Zheng JS, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f3706
NR 49
TC 1
Z9 1
U1 4
U2 14
PU SWEDISH NUTRITION FOUNDATION-SNF
PI LUND
PA IDEON SCIENCE PARK, BESOK SCHEELEV 17 BETA 5, 3V, LUND, 223 70, SWEDEN
SN 1654-6628
EI 1654-661X
J9 FOOD NUTR RES
JI Food Nutr. Res.
PD MAR 5
PY 2024
VL 68
AR 10485
DI 10.29219/fnr.v68.10485
PG 18
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA PW7H6
UT WOS:001217179600001
PM 38571914
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Elsaka, O
AF Elsaka, Omar
TI Novel Biomarkers in Vascular Diseases: From Discovery to Clinical
   Translation
SO INDIAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
LA English
DT Review
DE Atherosclerosis; biomarkers; cardiovascular diseases; clinical
   applications; diagnostic markers; endothelial activation; endothelial
   dysfunction; inflammation; insulin resistance; metabolic syndrome;
   nitric oxide; oxidative stress; pathogenesis; prediabetes; predictive
   markers; translational research; treatment strategies; type II diabetes;
   vascular diseases; vasodilation
AB Endothelial activation as well as dysfunction is a major factor in atherosclerosis, cardiovascular disorders, and cardiorenal syndrome. Endothelial dysfunction is additionally associated with metabolic syndrome as well as type II diabetes. The hunt for distinctive as well as sensitive biomarkers of endothelial activity and dysfunction may have substantial therapeutic consequences. This review pinpoints the variations in biomarkers that occur between endothelial activation and endothelial dysfunction in cardiovascular illnesses, and then briefly highlights the most significant biomarkers of endothelial activation. Biomarkers of endothelial activation consist of endothelial adhesion molecules, as well as cytokines, and C-reactive protein, along with CD62E++/E-selectin activated endothelial microparticles, and oxidation of low-density lipoproteins, together with asymmetric dimethylarginine as well as endocan. This study also includes an update on the new biomarkers of endothelial dysfunction, such as matrix metalloproteinases (MMP) (e.g., MMP-7, MMP-9), along with ANGPTL2, and endoglin, together with annexin V++ endothelium apoptotic microparticles, and serum homocysteine. Finally, this study stresses the limits of biomarkers of endothelium activation and dysfunction in clinical situations.
C1 [Elsaka, Omar] Mansoura Univ, Dept Cardiol, Mansoura Manchester Med Program MMMP, Fac Med, Mansoura, Egypt.
C3 Egyptian Knowledge Bank (EKB); Mansoura University
RP Elsaka, O (corresponding author), Mansoura Univ, Dept Cardiol, Mansoura Manchester Med Program MMMP, Fac Med, Mansoura, Egypt.
EM omarelsaka0808@gmail.com
RI Elsaka, Omar/ABP-4248-2022
OI Elsaka, Omar/0000-0003-1042-4715
CR Alexander Y, 2021, CARDIOVASC RES, V117, P29, DOI 10.1093/cvr/cvaa085
   Anghel L, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21061920
   Barbagallo C, 2020, CELL MOL NEUROBIOL, V40, P531, DOI 10.1007/s10571-019-00751-y
   Brown L., 2018, Heart J, V48, P987
   Eilenberg W, 2021, TRANSL RES, V233, P32, DOI 10.1016/j.trsl.2021.02.003
   Gasecka A, 2020, J CLIN MED, V9, DOI 10.3390/jcm9092807
   Harris K, 2022, FRONT PHYSIOL, V13, DOI 10.3389/fphys.2022.885183
   Johnson R., 2015, Circulation, V62, P1345
   Lawler Patrick R, 2021, Eur Heart J, V42, P113, DOI 10.1093/eurheartj/ehaa099
   Leite AR, 2020, ANGIOLOGY, V71, P397, DOI 10.1177/0003319720903586
   Lopes-Coelho F, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22073765
   Ma ZH, 2020, AM J PHYSIOL-CELL PH, V319, pC481, DOI 10.1152/ajpcell.00147.2020
   Medina-Leyte DJ, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22083850
   Memon AA, 2020, EUR J PREV CARDIOL, V27, P132, DOI 10.1177/2047487319873062
   Moaddel R, 2021, AGING CELL, V20, DOI 10.1111/acel.13325
   Moretti R, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23073508
   Nepomuceno R., 2021, Biomarkers, V30, P112
   Niu MY, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.791644
   Ouyang MX, 2021, BIOSENS BIOELECTRON, V171, DOI 10.1016/j.bios.2020.112621
   Palviainen M, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0236439
   Pugh D, 2022, NAT REV DIS PRIMERS, V7, DOI 10.1038/s41572-021-00327-5
   Ramon A, 2022, J CLIN MED, V11, DOI 10.3390/jcm11030495
   Remuzgo-Martinez S, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.894171
   Saenz-Pipaon G, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22073601
   Sahoo S, 2021, CIRCULATION, V143, P1426, DOI 10.1161/CIRCULATIONAHA.120.049254
   Sánchez-López V, 2024, AM J CLIN PATHOL, V161, P501, DOI 10.1093/ajcp/aqad178
   Schulte C, 2020, TRENDS MOL MED, V26, P583, DOI 10.1016/j.molmed.2020.02.001
   Smith J., 2010, J Nutr Health, V45, P234
   Souilhol C, 2018, CARDIOVASC RES, V114, P565, DOI 10.1093/cvr/cvx253
   Tikkanen E, 2021, J AM HEART ASSOC, V10, DOI 10.1161/JAHA.121.021995
   Tilea I, 2021, DIAGNOSTICS, V11, DOI 10.3390/diagnostics11050881
   Wang X., 2017, Genet Med, V19, P567
   Williams T., 2016, Heart Rhythm, V37, P1290
   Wong ND, 2022, AM J PREVENT CARDIOL, V10, DOI 10.1016/j.ajpc.2022.100335
   Yagi H, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-63229-8
   Ye Z, 2022, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.905921
   Zhang J, 2022, REV CARDIOVASC MED, V23, DOI 10.31083/j.rcm2302073
NR 37
TC 0
Z9 0
U1 0
U2 0
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 0972-0820
EI 2394-0999
J9 INDIAN J VASCULAR EN
JI Indian J. Vascular Endovasc. Surg.
PD JUL-SEP
PY 2024
VL 11
IS 3
BP 142
EP 151
DI 10.4103/ijves.ijves_42_24
PG 10
WC Cardiac & Cardiovascular Systems; Surgery
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology; Surgery
GA K9O0I
UT WOS:001347106500002
OA gold
DA 2025-06-11
ER

PT J
AU Panagiotou, C
   Mihailidou, C
   Brauhli, G
   Katsarou, O
   Moutsatsou, P
AF Panagiotou, Christina
   Mihailidou, Chrysovalantou
   Brauhli, George
   Katsarou, Olga
   Moutsatsou, Paraskevi
TI RETRACTED: Effect of steviol, steviol glycosides and stevia extract on
   glucocorticoid receptor signaling in normal and cancer blood cells
   (Retracted Article)
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article; Retracted Publication
DE Glucocorticoid receptor; Steviol; Steviol glycosides; PBMCs; Type 2
   diabetes mellitus; Metabolic syndrome
ID PITUITARY-ADRENAL AXIS; INDUCED LEUCINE-ZIPPER; PERIPHERAL-BLOOD;
   NATURAL SWEETENER; GENE-EXPRESSION; REBAUDIOSIDE-A; DEXAMETHASONE;
   HEALTHY; APOPTOSIS; STRESS
AB The use of steviol glycosides as non-caloric sweeteners has proven to be beneficial for patients with type 2 diabetes mellitus (T2D), obesity, and metabolic syndrome. However, recent data demonstrate that steviol and stevioside might act as glucocorticoid receptor (GR) agonists and thus correlate with adverse effects on metabolism. Herein, we evaluated the impact of steviol, steviol glycosides, and a Greek-derived stevia extract on a number of key steps of GR signaling cascade in peripheral blood mononuclear cells (PBMCs) and in Jurkat leukemia cells. Our results revealed that none of the tested compounds altered the expression of primary GR-target genes (GILZ, FKPB5), GR protein levels or GR subcellular localization in PBMCs; those compounds increased GILZ and FKPB5 mRNA levels as well as GRE-mediated luciferase activity, inducing in parallel GR nuclear translocation in Jurkat cells. The GR-modulatory activity demonstrated by stevia-compounds in Jurkat cells but not in PBMCs may be due to a cell-type specific effect. (C) 2017 Elsevier B.V. All rights reserved.
C1 [Panagiotou, Christina; Moutsatsou, Paraskevi] Natl & Kapodistrian Univ Athens, Univ Gen Hosp ATTIKO, Med Sch, Dept Clin Biochem, Athens, Greece.
   [Mihailidou, Chrysovalantou] Natl & Kapodistrian Univ Athens, Med Sch, Dept Biol Chem, Athens, Greece.
   [Brauhli, George] ANTHIR SA Co, Agrinion, Greece.
   [Katsarou, Olga] Laikon Gen Hosp, Blood Transfus Ctr 2, Athens, Greece.
   [Katsarou, Olga] Laikon Gen Hosp, Hemophilia Ctr, Athens, Greece.
C3 University Hospital Attikon; National & Kapodistrian University of
   Athens; National & Kapodistrian University of Athens; Laiko General
   Hospital; Laiko General Hospital
RP Moutsatsou, P (corresponding author), Univ Athens, Med Sch, Univ Hosp ATTIKO, Athens 12462, Greece.
EM pmoutsatsou@med.uoa.gr
RI MOUTSATSOU, PARASKEVI/JFA-5539-2023
FU Greek Secretariat of Research and Technology, Ministry of Development
   (Grant ESPA) [11SigmaYN_2_741]; GIOTIS S.A.
FX This research is supported by the Greek Secretariat of Research and
   Technology, Ministry of Development (Grant ESPA, 11 Sigma YN_2_741) in
   cooperation with the company GIOTIS S.A. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
CR Aguilar F., 2010, EFSA J, V8, P1
   Amoêdo ND, 2013, BIOSCIENCE REP, V33, P865, DOI 10.1042/BSR20130066
   Ayroldi E, 2014, FASEB J, V28, P5055, DOI 10.1096/fj.14-254755
   Boonkaewwan C, 2008, J AGR FOOD CHEM, V56, P3777, DOI 10.1021/jf072681o
   Boonkaewwan C, 2013, J SCI FOOD AGR, V93, P3820, DOI 10.1002/jsfa.6287
   Brahmachari G, 2011, ARCH PHARM, V344, P5, DOI 10.1002/ardp.201000181
   Burkhart BA, 2009, MOL CELL ENDOCRINOL, V298, P66, DOI 10.1016/j.mce.2008.10.011
   Cain DW, 2015, BEST PRACT RES CL EN, V29, P545, DOI 10.1016/j.beem.2015.04.007
   Carakostas MC, 2008, FOOD CHEM TOXICOL, V46, pS1, DOI 10.1016/j.fct.2008.05.003
   Chang SF, 2006, J NAT PROD, V69, P1450, DOI 10.1021/np0602564
   Chatsudthipong V, 2009, PHARMACOL THERAPEUT, V121, P41, DOI 10.1016/j.pharmthera.2008.09.007
   Chrousos George P, 2005, Sci STKE, V2005, ppe48, DOI 10.1126/stke.3042005pe48
   Cooper MS, 2016, BONE, V82, P64, DOI 10.1016/j.bone.2015.05.038
   Coutinho AE, 2011, MOL CELL ENDOCRINOL, V335, P2, DOI 10.1016/j.mce.2010.04.005
   D'Adamio F, 1997, IMMUNITY, V7, P803, DOI 10.1016/S1074-7613(00)80398-2
   Ena Gupta Ena Gupta, 2013, Journal of Medicinal Plants Research, V7, P3343
   Galigniana NM, 2012, J NEUROCHEM, V122, P4, DOI 10.1111/j.1471-4159.2012.07775.x
   Geuns JMC, 2007, EXP BIOL MED, V232, P164
   Geuns JMC, 2006, J AGR FOOD CHEM, V54, P2794, DOI 10.1021/jf052693e
   Hakim A, 2013, FASEB J, V27, P4510, DOI 10.1096/fj.12-222604
   Kazakou P, 2012, HORM METAB RES, V44, P839, DOI 10.1055/s-0032-1311632
   Khalaf H, 2010, BMC IMMUNOL, V11, DOI 10.1186/1471-2172-11-26
   Menke A, 2012, NEUROPSYCHOPHARMACOL, V37, P1455, DOI 10.1038/npp.2011.331
   Meyer TPH, 2005, J IMMUNOL METHODS, V307, P150, DOI 10.1016/j.jim.2005.10.004
   Mihailidou C, 2016, MOL CELL ENDOCRINOL, V436, P211, DOI 10.1016/j.mce.2016.08.001
   Mohd-Radzman NH, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/938081
   Moutsatsou P, 2012, TRENDS MOL MED, V18, P348, DOI 10.1016/j.molmed.2012.04.005
   Oakley RH, 2011, J BIOL CHEM, V286, P3177, DOI 10.1074/jbc.R110.179325
   PASQUALI R, 1993, J CLIN ENDOCR METAB, V77, P341, DOI 10.1210/jc.77.2.341
   Paul S, 2012, NUTR CANCER, V64, P1087, DOI 10.1080/01635581.2012.712735
   Pujols L, 2002, AM J PHYSIOL-CELL PH, V283, pC1324, DOI 10.1152/ajpcell.00363.2001
   Qattan MY, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0178606
   Sehar I, 2008, CHEM-BIOL INTERACT, V173, P115, DOI 10.1016/j.cbi.2008.01.008
   Shannon M, 2016, MOL CELL ENDOCRINOL, V427, P65, DOI 10.1016/j.mce.2016.03.005
   Smit P, 2005, J CLIN ENDOCR METAB, V90, P2994, DOI 10.1210/jc.2004-2298
   Smith LK, 2010, PROG BRAIN RES, V182, P1, DOI 10.1016/S0079-6123(10)82001-1
   Smoak KA, 2004, MECH AGEING DEV, V125, P697, DOI 10.1016/j.mad.2004.06.010
   Totino PRR, 2006, CELL BIOL INT, V30, P133, DOI 10.1016/j.cellbi.2005.09.002
   van Vliet-Ostaptchouk JV, 2014, BMC ENDOCR DISORD, V14, DOI 10.1186/1472-6823-14-9
   Vasko L, 2014, IN VITRO CELL DEV-AN, V50, P614, DOI 10.1007/s11626-014-9751-4
   Vegiopoulos A., 2007, MOL CELL ENDOCRINOL, V43-61, p[15, 275]
   Wang TC, 2014, INFLAMMATION, V37, P1837, DOI 10.1007/s10753-014-9915-0
   Wheeler A, 2008, FOOD CHEM TOXICOL, V46, pS54, DOI 10.1016/j.fct.2008.04.041
   Yadav SK, 2012, CRIT REV FOOD SCI, V52, P988, DOI 10.1080/10408398.2010.519447
NR 44
TC 27
Z9 27
U1 0
U2 33
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
EI 1872-8057
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD JAN 15
PY 2018
VL 460
IS C
BP 189
EP 199
DI 10.1016/j.mce.2017.07.023
PG 11
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA FU5LD
UT WOS:000423893300018
PM 28754349
DA 2025-06-11
ER

PT J
AU Huber, K
   Szerenos, E
   Lewandowski, D
   Toczylowski, K
   Sulik, A
AF Huber, Korbinian
   Szerenos, Emilia
   Lewandowski, Dawid
   Toczylowski, Kacper
   Sulik, Artur
TI The Role of Adipokines in the Pathologies of the Central Nervous System
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE adipokines; adipose tissue; Alzheimer's disease; depression; protein
   hormones; multiple sclerosis; neurological dysfunctions; meningitis;
   encephalitis
ID CYSTATIN C LEVELS; PEPTIDASE-IV ACTIVITY; F344 RAT SUBSTRAINS;
   CEREBROSPINAL-FLUID; CHITINASE-3-LIKE PROTEIN-1; METABOLIC SYNDROME;
   NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; POTENTIAL BIOMARKER; SERUM
   OMENTIN-1; NEUROPEPTIDE-Y
AB Adipokines are protein hormones secreted by adipose tissue in response to disruptions in physiological homeostasis within the body's systems. The regulatory functions of adipokines within the central nervous system (CNS) are multifaceted and intricate, and they have been identified in a number of pathologies. Therefore, specific adipokines have the potential to be used as biomarkers for screening purposes in neurological dysfunctions. The systematic review presented herein focuses on the analysis of the functions of various adipokines in the pathogenesis of CNS diseases. Thirteen proteins were selected for analysis through scientific databases. It was found that these proteins can be identified within the cerebrospinal fluid either by their ability to modify their molecular complex and cross the blood-brain barrier or by being endogenously produced within the CNS itself. As a result, this can correlate with their measurability during pathological processes, including Alzheimer's disease, amyotrophic lateral sclerosis, multiple sclerosis, depression, or brain tumors.
C1 [Huber, Korbinian; Szerenos, Emilia; Lewandowski, Dawid; Toczylowski, Kacper; Sulik, Artur] Med Univ Bialystok, Dept Pediat Infect Dis, Waszyngtona 17, PL-15274 Bialystok, Poland.
C3 Medical University of Bialystok
RP Toczylowski, K (corresponding author), Med Univ Bialystok, Dept Pediat Infect Dis, Waszyngtona 17, PL-15274 Bialystok, Poland.
EM kacper.toczylowski@umb.edu.pl
RI Lewandowski, Dawid/KWT-9716-2024; Sulik, Artur/S-6083-2018; Toczylowski,
   Kacper/S-4595-2018
OI Sulik, Artur/0000-0002-8391-4793; Toczylowski,
   Kacper/0000-0003-0309-6987; Lewandowski, Dawid/0009-0006-9004-8623
CR Acik V, 2020, CLIN NEUROL NEUROSUR, V194, DOI 10.1016/j.clineuro.2020.105837
   Adeghate E, 2008, CURR MED CHEM, V15, P1851, DOI 10.2174/092986708785133004
   Areshkov PA, 2010, CYTOL GENET+, V44, P1, DOI 10.3103/S0095452710010019
   Azamar-Llamas D, 2017, MEDIAT INFLAMM, V2017, DOI 10.1155/2017/5468023
   Baumann G., 2004, Encyclopedia of Endocrine Diseases, P383
   Bissel SJ, 2016, J NEUROIMMUNE PHARM, V11, P332, DOI 10.1007/s11481-016-9666-9
   Bloemer J, 2018, NEURAL PLAST, V2018, DOI 10.1155/2018/4593530
   Bonneh-Barkay D, 2008, AM J PATHOL, V173, P130, DOI 10.2353/ajpath.2008.080045
   Booth A, 2016, HORM MOL BIOL CLIN I, V26, P25, DOI 10.1515/hmbci-2015-0073
   Bozaoglu K, 2009, J CLIN ENDOCR METAB, V94, P3085, DOI 10.1210/jc.2008-1833
   Briana DD, 2011, METABOLISM, V60, P486, DOI 10.1016/j.metabol.2010.04.014
   Burgdorf J, 2017, INT J NEUROPSYCHOPH, V20, P476, DOI 10.1093/ijnp/pyx007
   Cantó E, 2015, BRAIN, V138, P918, DOI 10.1093/brain/awv017
   Chen J, 2012, PEPTIDES, V38, P8, DOI 10.1016/j.peptides.2012.08.016
   Chuma M, 2020, ACTA MED OKAYAMA, V74, P365, DOI 10.18926/AMO/60376
   Cisternas P, 2019, MOL NEUROBIOL, V56, P3024, DOI 10.1007/s12035-018-1271-x
   Connolly K, 2023, ALZHEIMERS DEMENT, V19, P9, DOI 10.1002/alz.12612
   Constant O, 2022, VIRUSES-BASEL, V14, DOI 10.3390/v14040756
   Corem N, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-39230-1
   Cowley MA, 2001, NATURE, V411, P480, DOI 10.1038/35078085
   Czupryna P, 2022, TICKS TICK-BORNE DIS, V13, DOI 10.1016/j.ttbdis.2022.101895
   da Silva AA, 2021, DIABETES, V70, P2264, DOI 10.2337/db21-0126
   Delanaye P, 2015, CLIN J AM SOC NEPHRO, V10, P1504, DOI 10.2215/CJN.07860715
   Di Spiezio A, 2018, MOL METAB, V8, P13, DOI 10.1016/j.molmet.2017.12.001
   Dietrich MO, 2008, NEUROBIOL AGING, V29, P902, DOI 10.1016/j.neurobiolaging.2007.01.008
   Ding HH, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00499
   Dong XQ, 2010, CRIT CARE, V14, DOI 10.1186/cc9307
   Dotsch J, 1997, J NEUROL SCI, V151, P185, DOI 10.1016/S0022-510X(97)00116-0
   Du XY, 2009, J BIOL CHEM, V284, P751, DOI 10.1074/jbc.M805000200
   Elabi OF, 2023, DIABETES, V72, P405, DOI 10.2337/db22-0674
   Elisabetta S, 2021, MOL NEUROBIOL, V58, P2663, DOI 10.1007/s12035-021-02287-z
   Erfani S, 2015, NEUROPEPTIDES, V49, P63, DOI 10.1016/j.npep.2014.12.004
   Ernst MC, 2010, TRENDS ENDOCRIN MET, V21, P660, DOI 10.1016/j.tem.2010.08.001
   Firth SM, 2002, ENDOCR REV, V23, P824, DOI 10.1210/er.2001-0033
   Graham KL, 2009, J IMMUNOL, V183, P6717, DOI 10.4049/jimmunol.0803435
   Guo Q, 2020, DIGEST LIVER DIS, V52, P573, DOI 10.1016/j.dld.2019.10.008
   Hoghooghi V, 2020, CELL REP, V33, DOI 10.1016/j.celrep.2020.108236
   Hu P, 2015, AM J PHYSIOL-ENDOC M, V308, pE688, DOI 10.1152/ajpendo.00504.2014
   Huang HH, 2020, EXP GERONTOL, V142, DOI 10.1016/j.exger.2020.111138
   Huang Y, 2021, DIABET METAB SYND OB, V14, P857, DOI 10.2147/DMSO.S295088
   Jamali-Raeufy N, 2020, J CHEM NEUROANAT, V110, DOI 10.1016/j.jchemneu.2020.101855
   Ji LR, 2023, MOL CELL ENDOCRINOL, V574, DOI 10.1016/j.mce.2023.111990
   Jian JL, 2018, EBIOMEDICINE, V28, P251, DOI 10.1016/j.ebiom.2018.01.022
   Johnston A, 2008, BRIT J DERMATOL, V159, P342, DOI 10.1111/j.1365-2133.2008.08655.x
   JONES JI, 1995, ENDOCR REV, V16, P3, DOI 10.1210/er.16.1.3
   Karl T, 2003, PHYSIOL BEHAV, V80, P123, DOI 10.1016/S0031-9384(03)00229-4
   Karl T, 2003, PHARMACOL BIOCHEM BE, V75, P869, DOI 10.1016/S0091-3057(03)00154-0
   Kasai A, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023968
   Kazama K, 2014, AM J PHYSIOL-HEART C, V306, pH1714, DOI 10.1152/ajpheart.00048.2014
   Khan S, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00822
   Khattab FM, 2019, INT J DERMATOL, V58, P993, DOI 10.1111/ijd.14551
   Kim H, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21082871
   Kim MW, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-12632-9
   Kishida K, 2014, BEST PRACT RES CL EN, V28, P119, DOI 10.1016/j.beem.2013.08.006
   Kocijancic M, 2015, DIABETES RES CLIN PR, V110, P44, DOI 10.1016/j.diabres.2015.06.008
   Korzh O, 2021, METABOLISM, V116, P11, DOI 10.1016/j.metabol.2020.154494
   Kursawe R, 2014, ADV CLIN CHEM, V65, P91, DOI 10.1016/B978-0-12-800141-7.00004-8
   Kzhyshkowska J, 2007, BIOMARK INSIGHTS, V2, P128
   La Cava A, 2004, NAT REV IMMUNOL, V4, P371, DOI 10.1038/nri1350
   Lande R, 2008, J NEUROPATH EXP NEUR, V67, P388, DOI 10.1097/NEN.0b013e31816fc975
   Langlois V., 2008, Comprehensive Pediatric Nephrology, P39
   Lee THY, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20225638
   Lei ZN, 2022, SIGNAL TRANSDUCT TAR, V7, DOI 10.1038/s41392-022-01190-w
   Levy E, 2006, BRAIN PATHOL, V16, P60, DOI 10.1111/j.1750-3639.2006.tb00562.x
   Liang ZX, 2019, J NEUROINFLAMM, V16, DOI 10.1186/s12974-019-1573-6
   Lin B, 2018, Hepatoma Res, V4, P48, DOI DOI 10.20517/2394-5079.2018.19
   Liu TT, 2015, INT J MOL SCI, V16, P11439, DOI 10.3390/ijms160511439
   Maes M, 1997, PSYCHONEUROENDOCRINO, V22, P65, DOI 10.1016/S0306-4530(96)00040-6
   Miao J, 2013, CNS NEUROSCI THER, V19, P969, DOI 10.1111/cns.12198
   Miehle K, 2016, CLIN ENDOCRINOL, V84, P932, DOI 10.1111/cen.12976
   Mishra PK, 2013, BRAIN BEHAV IMMUN, V34, P98, DOI 10.1016/j.bbi.2013.07.176
   Miura S, 2015, J DERMATOL, V42, P461, DOI 10.1111/1346-8138.12824
   Moniuszko A, 2012, CYTOKINE, V60, P468, DOI 10.1016/j.cyto.2012.05.007
   Morton GJ, 2006, NATURE, V443, P289, DOI 10.1038/nature05026
   MULLER HL, 1993, J CLIN ENDOCR METAB, V77, P1113, DOI 10.1210/jc.77.5.1113
   Musovic S, 2021, BIOCHEM BIOPH RES CO, V534, P707, DOI 10.1016/j.bbrc.2020.11.013
   Nagai A, 2003, CLIN CHIM ACTA, V329, P53, DOI 10.1016/S0009-8981(03)00023-8
   Naspi A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0098641
   Ndjole AM, 2010, J IMMUNOL METHODS, V360, P84, DOI 10.1016/j.jim.2010.06.012
   Nishijima T, 2010, NEURON, V67, P834, DOI 10.1016/j.neuron.2010.08.007
   Nyirenda MH, 2021, MULT SCLER J, V27, P1948, DOI 10.1177/1352458521989090
   Opatrilova R, 2018, BIOMED PHARMACOTHER, V98, P424, DOI 10.1016/j.biopha.2017.12.074
   Otero M, 2006, ANN RHEUM DIS, V65, P1198, DOI 10.1136/ard.2005.046540
   Palmer C, 2008, HEPATOLOGY, V48, P374, DOI 10.1002/hep.22387
   Pan W, 2007, PEPTIDES, V28, P1317, DOI 10.1016/j.peptides.2007.04.023
   Park BS, 2011, PLOS ONE, V6, DOI [10.1371/journal.pone.0015981, 10.1371/journal.pone.0026943]
   Pinteac R, 2021, NEUROL-NEUROIMMUNOL, V8, DOI 10.1212/NXI.0000000000000921
   Pinto S, 2004, SCIENCE, V304, P110, DOI 10.1126/science.1089459
   Rajesh Y, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22042163
   Ramos-Leví AM, 2016, PROG MOL BIOL TRANSL, V138, P85, DOI 10.1016/bs.pmbts.2015.10.016
   Rathcke CN, 2006, INFLAMM RES, V55, P221, DOI 10.1007/s00011-006-0076-y
   Rauzier C, 2022, J LIPID RES, V63, DOI 10.1016/j.jlr.2022.100269
   Reinhold D, 2006, INT IMMUNOPHARMACOL, V6, P1935, DOI 10.1016/j.intimp.2006.07.023
   Ren Q, 2022, LIPIDS HEALTH DIS, V21, DOI 10.1186/s12944-022-01637-7
   Rijnsburger M, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms221910845
   Rosa M.D., 2013, Mod. Res. Inflamm, V2, P82, DOI [10.4236/mri.2013.24011, DOI 10.4236/MRI.2013.24011]
   Ng RCL, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18030592
   Sahin B, 2019, SAUDI MED J, V40, P26, DOI 10.15537/smj.2019.1.23396
   Sahpolat M, 2020, CLIN PSYCHOPHARM NEU, V18, P109, DOI 10.9758/cpn.2020.18.1.109
   Sako W, 2014, NEUROL CLIN NEUROSCI, V2, P72, DOI 10.1111/ncn3.82
   Sakoda ME, 2017, JAIDS-J ACQ IMM DEF, V74, P243, DOI 10.1097/QAI.0000000000001235
   Salomon J, 2018, POSTEP DERM ALERGOL, V35, P485, DOI 10.5114/ada.2018.77239
   Carabias CS, 2020, WORLD NEUROSURG, V134, pE120, DOI 10.1016/j.wneu.2019.09.143
   Sanna V, 2003, J CLIN INVEST, V111, P241, DOI 10.1172/JCI200316721
   Sayed NH, 2020, NEUROTHERAPEUTICS, V17, P252, DOI 10.1007/s13311-019-00805-5
   Scheid MP, 2014, REV ENDOCR METAB DIS, V15, P157, DOI 10.1007/s11154-013-9265-5
   Schindler N, 2017, GROWTH HORM IGF RES, V33, P1, DOI 10.1016/j.ghir.2016.11.003
   Schön M, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-38201-2
   Sell H, 2010, J CLIN ENDOCR METAB, V95, P2892, DOI 10.1210/jc.2009-2374
   Sell H, 2009, DIABETES, V58, P2731, DOI 10.2337/db09-0277
   Sharples AP, 2013, GROWTH HORM IGF RES, V23, P53, DOI 10.1016/j.ghir.2013.03.004
   Shen FP, 2019, BRAIN RES, V1704, P174, DOI 10.1016/j.brainres.2018.10.018
   Sierra-Honigmann MR, 1998, SCIENCE, V281, P1683, DOI 10.1126/science.281.5383.1683
   Singh R, 2021, PHARMACOL RES, V167, DOI 10.1016/j.phrs.2020.105414
   Smitka Kvido, 2015, Prague Med Rep, V116, P87, DOI 10.14712/23362936.2015.49
   Song J, 2015, CELL DEATH DIS, V6, DOI 10.1038/cddis.2015.220
   Steppan CM, 2001, NATURE, V409, P307, DOI 10.1038/35053000
   Sturny M, 2021, J SEX MED, V18, P875, DOI 10.1016/j.jsxm.2021.02.004
   Su X, 2021, CLIN CHIM ACTA, V516, P8, DOI 10.1016/j.cca.2021.01.013
   Sun LH, 2021, CANCER LETT, V500, P132, DOI 10.1016/j.canlet.2020.12.008
   Suzuki H, 2021, BIOL PHARM BULL, V44, P1548, DOI 10.1248/bpb.b21-00461
   Taylan A, 2021, ARCH MED RES, V52, P544, DOI 10.1016/j.arcmed.2021.02.002
   Nguyen TD, 2020, INT J PREVENTIVE MED, V11, DOI 10.4103/ijpvm.IJPVM_193_20
   Thundyil J, 2012, BRIT J PHARMACOL, V165, P313, DOI 10.1111/j.1476-5381.2011.01560.x
   Tilinca MC, 2018, REV ROMANA MED LAB, V26, P359, DOI 10.2478/rrlm-2018-0019
   Tsuruha JI, 2002, J RHEUMATOL, V29, P1459
   Vafaei-Nezhad S, 2021, J CHEM NEUROANAT, V113, DOI 10.1016/j.jchemneu.2021.101924
   Verma S, 2003, CIRCULATION, V108, P736, DOI 10.1161/01.CIR.0000084503.91330.49
   Waki H, 2003, J BIOL CHEM, V278, P40352, DOI 10.1074/jbc.M300365200
   Wang SN, 2016, CNS NEUROSCI THER, V22, P431, DOI 10.1111/cns.12539
   Wang Y, 2014, MED ONCOL, V31, DOI 10.1007/s12032-014-0921-8
   Wang Z, 2021, IMMUNOL LETT, V233, P92, DOI 10.1016/j.imlet.2021.02.008
   Waragai M, 2017, ANN CLIN TRANSL NEUR, V4, P591, DOI 10.1002/acn3.436
   Xu T, 2020, CLIN CHIM ACTA, V505, P167, DOI 10.1016/j.cca.2020.03.007
   Xu WL, 2019, J NEUROINFLAMM, V16, DOI 10.1186/s12974-019-1620-3
   Yamamoto A, 2020, PFLUG ARCH EUR J PHY, V472, P673, DOI 10.1007/s00424-020-02391-4
   Yang B, 2020, J NEUROCHEM, V153, P413, DOI 10.1111/jnc.14894
   Yang JY, 2020, BRAIN BEHAV, V10, DOI 10.1002/brb3.1678
   Yang YR, 2009, MOL BIOL REP, V36, P677, DOI 10.1007/s11033-008-9228-1
   Yoon MJ, 2006, DIABETES, V55, P2562, DOI 10.2337/db05-1322
   Yue JY, 2018, CYTOKINE, V111, P518, DOI 10.1016/j.cyto.2018.05.026
   Zhang J, 2015, PROTEIN CELL, V6, P254, DOI 10.1007/s13238-014-0131-3
   Zhang K, 2017, MOL NEUROBIOL, V54, P4908, DOI 10.1007/s12035-016-0036-7
   Zhao L, 2011, J BIOL CHEM, V286, P39520, DOI 10.1074/jbc.M111.258954
   Zhao LR, 2015, MOL MED REP, V11, P1859, DOI 10.3892/mmr.2014.2937
   Zhao T, 2020, SIGNAL TRANSDUCT TAR, V5, DOI 10.1038/s41392-020-00303-7
   Zhao Y, 2014, CNS NEUROSCI THER, V20, P539, DOI 10.1111/cns.12273
   Zhou JX, 2021, NEUROPEPTIDES, V87, DOI 10.1016/j.npep.2021.102131
   Zhou L, 2021, CLIN CHIM ACTA, V512, P84, DOI 10.1016/j.cca.2020.11.010
   Zhou Y, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19010073
   Zhuang YK, 2021, CLIN CHIM ACTA, V516, P64, DOI 10.1016/j.cca.2021.01.014
NR 151
TC 9
Z9 9
U1 1
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2023
VL 24
IS 19
AR 14684
DI 10.3390/ijms241914684
PG 27
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA U8MQ3
UT WOS:001087292000001
PM 37834128
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Savoy, SM
   Penckofer, S
AF Savoy, Suzanne M.
   Penckofer, Sue
TI Depressive Symptoms Impact Health-Promoting Lifestyle Behaviors and
   Quality of Life in Healthy Women
SO JOURNAL OF CARDIOVASCULAR NURSING
LA English
DT Article
DE depression; quality of life; risk factors; women
ID CORONARY-HEART-DISEASE; ACUTE MYOCARDIAL-INFARCTION; RISK-FACTOR;
   CARDIOVASCULAR RISK; PHYSICAL-ACTIVITY; METABOLIC SYNDROME; 52
   COUNTRIES; MORTALITY; ASSOCIATION; ANXIETY
AB Background: Depressive symptoms are an independent risk factor of cardiovascular disease (CVD). More than 15% of persons with CVD have depressive symptoms, which are twice as likely to occur in women. Depressive symptoms in women being screened for CVD have not been well studied.
   Objective: The relationships between depressive symptoms, health-promoting lifestyle behaviors, heart disease risk awareness, cardiac risk, and quality of life (QOL) in women were investigated. Whether the effect of depressive symptoms on QOL was mediated by cardiac risk and/or health-promoting lifestyle behaviors was also examined.
   Methods: The Wilson-Cleary Health-Related Quality of Life Model guided this descriptive study. A convenience sample of 125 women was recruited from cardiac health screening events. The study measurements were the Center for Epidemiologic Studies Depression Scale; the Framingham risk score; the Ferrans-Powers Quality of Life Index Generic Version-III; the Health-Promoting Lifestyle Profile-II; and questions related to heart disease risk, awareness of heart disease risk, health history, and demographics. Body mass index, percentage of body fat, and lipid profile were also measured.
   Results: More than one-third (34%) of the women reported significant depressive symptoms. Depressive symptoms were not associated with cardiac risk or risk awareness but were inversely associated with health-promoting lifestyle behaviors (r = -0.37, P < 0.01) and QOL (r = -0.51, P < 0.01). There was a dose-response relationship with health-promoting lifestyle behaviors (odds ratio, 0.92; 95% confidence interval, 0.88-0.97; P < 0.001) and QOL (odds ratio, 0.85; 95% confidence interval, 0.79-0.92; P < 0.001) and depressive symptoms. Health-promoting lifestyle behaviors mediated the association between depressive symptoms and QOL.
   Conclusions: Depressive symptoms contribute significantly to health-promoting lifestyle behaviors and QOL for women. Early detection and treatment of depressive symptoms are important for participation in healthy lifestyle behaviors, which could result in improved QOL.
C1 [Savoy, Suzanne M.] Saginaw Valley State Univ, Coll Hlth & Human Serv, Dept Nursing, University Ctr, PA 48710 USA.
   [Penckofer, Sue] Loyola Univ Chicago Niehoff, Sch Nursing, Maywood, IL USA.
C3 Loyola University Chicago
RP Savoy, SM (corresponding author), Saginaw Valley State Univ, 7400 Bay Rd,HHS Rm 233, University Ctr, PA 48710 USA.
EM smsavoy@svsu.edu
FU Columbia-Presbyterian Hospital School of Nursing Alumni Association,
   Inc; Saginaw Valley State University; Theta Chi Chapter, Sigma Theta Tau
   International
FX Supported by graduate scholarship from Columbia-Presbyterian Hospital
   School of Nursing Alumni Association, Inc, and by research grants from
   Saginaw Valley State University and Theta Chi Chapter, Sigma Theta Tau
   International.
CR Acton GJ, 2000, WESTERN J NURS RES, V22, P796, DOI 10.1177/01939450022044764
   Agatisa PIK, 2005, ARCH INTERN MED, V165, P1229, DOI 10.1001/archinte.165.11.1229
   [Anonymous], 1995, NATL CHOLESTEROL ED, P1
   [Anonymous], NOTOD01053 NIH
   [Anonymous], 2012, Defining overweight and obesity
   Ariyo AA, 2000, CIRCULATION, V102, P1773
   Astin F, 2005, HEART LUNG, V34, P393, DOI 10.1016/j.hrtlng.2005.05.002
   Barefoot JC, 1996, CIRCULATION, V93, P1976, DOI 10.1161/01.CIR.93.11.1976
   BARON RM, 1986, J PERS SOC PSYCHOL, V51, P1173, DOI 10.1037/0022-3514.51.6.1173
   Blumenthal JA, 2012, J AM COLL CARDIOL, V60, P1053, DOI 10.1016/j.jacc.2012.04.040
   Bonnet F, 2005, ATHEROSCLEROSIS, V178, P339, DOI 10.1016/j.atherosclerosis.2004.08.035
   Brown JM, 2011, AM J GERIAT PSYCHIAT, V19, P721, DOI 10.1097/JGP.0b013e3181faee19
   Brown WJ, 2005, AM J PREV MED, V29, P265, DOI 10.1016/j.amepre.2005.06.009
   Cholestech Corp, 2006, ACC REPR POINT OF CA
   Cohen J., 1988, STAT POWER ANAL BEHA, DOI [10.4324/9780203771587, DOI 10.4324/9780203771587]
   D'Agostino RB, 2008, CIRCULATION, V117, P743, DOI 10.1161/CIRCULATIONAHA.107.699579
   DiMatteo MR, 2000, ARCH INTERN MED, V160, P2101, DOI 10.1001/archinte.160.14.2101
   Elovainio M, 2005, PSYCHOSOM MED, V67, P561, DOI 10.1097/01.psy.0000170340.74035.23
   FARMER ME, 1988, AM J EPIDEMIOL, V128, P1340, DOI 10.1093/oxfordjournals.aje.a115087
   Ferketich AK, 2000, ARCH INTERN MED, V160, P1261, DOI 10.1001/archinte.160.9.1261
   Ferrans CE, 2005, J NURS SCHOLARSHIP, V37, P336, DOI 10.1111/j.1547-5069.2005.00058.x
   Ferrans CE, QUALITY LIFE INDEX G
   Finkelstein EA, 2004, J WOMENS HEALTH, V13, P503, DOI 10.1089/1540999041280963
   Ford DE, 1998, ARCH INTERN MED, V158, P1422, DOI 10.1001/archinte.158.13.1422
   Ford ES, 2008, J WOMENS HEALTH, V17, P757, DOI 10.1089/jwh.2007.0468
   Fortin Martin, 2005, Health Qual Life Outcomes, V3, P74, DOI 10.1186/1477-7525-3-74
   Franklin BA, 2011, CIRCULATION, V123, P2274, DOI 10.1161/CIRCULATIONAHA.110.981613
   Frasure-Smith N, 2010, POSTGRAD MED J, V86, P193, DOI 10.1136/hrt.2009.186957
   Gilmour Heather, 2008, Health Rep, V19, P7
   Go AS, 2013, CIRCULATION, V127, pE6, DOI 10.1161/CIR.0b013e31828124ad
   GREEN SB, 1991, MULTIVAR BEHAV RES, V26, P499, DOI 10.1207/s15327906mbr2603_7
   Groll DL, 2005, J CLIN EPIDEMIOL, V58, P595, DOI 10.1016/j.jclinepi.2004.10.018
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Gump BB, 2005, STROKE, V36, P98, DOI 10.1161/01.STR.0000149626.50127.d0
   Hann D, 1999, J PSYCHOSOM RES, V46, P437, DOI 10.1016/S0022-3999(99)00004-5
   Hasin DS, 2005, ARCH GEN PSYCHIAT, V62, P1097, DOI 10.1001/archpsyc.62.10.1097
   Holmbeck GN, 1997, J CONSULT CLIN PSYCH, V65, P599, DOI 10.1037/0022-006X.65.4.599
   Hsia J, 2010, CIRC-CARDIOVASC QUAL, V3, P128, DOI 10.1161/CIRCOUTCOMES.108.842385
   Huffman JC, 2006, AM J CARDIOL, V98, P319, DOI 10.1016/j.amjcard.2006.02.033
   Kamm-Steigelman Lucia, 2006, Issues Ment Health Nurs, V27, P141, DOI 10.1080/01612840500436925
   Katon WJ, 2003, BIOL PSYCHIAT, V54, P216, DOI 10.1016/S0006-3223(03)00273-7
   Knox S, 2006, INT J BEHAV MED, V13, P44, DOI 10.1207/s15327558ijbm1301_6
   Kobau Rosemarie, 2004, Health Qual Life Outcomes, V2, P40, DOI 10.1186/1477-7525-2-40
   Kubzansky LD, 2000, J PSYCHOSOM RES, V48, P323, DOI 10.1016/S0022-3999(99)00091-4
   Kuper Hannah, 2002, Semin Vasc Med, V2, P267, DOI 10.1055/s-2002-35401
   Lichtman JH, 2008, CIRCULATION, V118, P1768, DOI 10.1161/CIRCULATIONAHA.108.190769
   Lloyd-Jones DM, 2010, CIRCULATION, V121, P586, DOI 10.1161/CIRCULATIONAHA.109.192703
   McGuire KA, 2009, AM J CARDIOL, V104, P1522, DOI 10.1016/j.amjcard.2009.07.023
   Mittag O, 2012, INT J PUBLIC HEALTH, V57, P79, DOI 10.1007/s00038-011-0256-6
   Mosca L, 2013, CIRCULATION, V127, P1254, DOI 10.1161/CIR.0b013e318287cf2f
   Mosca L, 2011, J AM COLL CARDIOL, V57, P1404, DOI [10.1016/j.jacc.2011.02.005, 10.1161/CIR.0b013e31820faaf8]
   OCED, 2001, GLOSS STAT TERMS
   Omron, OMR INSTR MAN FAT LO
   Penninx BWJH, 2001, ARCH GEN PSYCHIAT, V58, P221, DOI 10.1001/archpsyc.58.3.221
   Pratt LA, 1996, CIRCULATION, V94, P3123, DOI 10.1161/01.CIR.94.12.3123
   RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Rasul F, 2005, J EPIDEMIOL COMMUN H, V59, P140, DOI 10.1136/jech.2004.019786
   Rosal MC, 2001, PREV MED, V33, P586, DOI 10.1006/pmed.2001.0929
   Rosengren A, 2004, LANCET, V364, P953, DOI 10.1016/S0140-6736(04)17019-0
   Rugulies R, 2002, AM J PREV MED, V23, P51, DOI 10.1016/S0749-3797(02)00439-7
   Ruo B, 2003, JAMA-J AM MED ASSOC, V290, P215, DOI 10.1001/jama.290.2.215
   Sacco RL, 2009, J AM COLL CARDIOL, V54, P2303, DOI 10.1016/j.jacc.2009.07.047
   Sadek N, 2000, DEPRESS ANXIETY, V12, P30, DOI 10.1002/1520-6394(2000)12:1<30::AID-DA4>3.0.CO;2-P
   Sesso HD, 1998, AM J CARDIOL, V82, P851, DOI 10.1016/S0002-9149(98)00491-3
   Sobel ME., 1982, SOCIOL METHODOL, V13, P290, DOI DOI 10.2307/270723
   Spertus J, 2004, CONT CARDIOLOGY CORN
   Strike PC, 2004, PROG CARDIOVASC DIS, V46, P337, DOI 10.1016/j.pcad.2003.09.001
   Thurston RC, 2007, PSYCHOSOM MED, V69, P748, DOI 10.1097/PSY.0b013e31815772a3
   Towfighi A, 2009, ARCH INTERN MED, V169, P1762, DOI 10.1001/archinternmed.2009.318
   Van der Kooy K, 2007, INT J GERIATR PSYCH, V22, P613, DOI 10.1002/gps.1723
   Vinkers D, 2005, ARCH INTERN MED, V165, P119, DOI 10.1001/archinte.165.1.119-a
   Walker S.N., 1995, HLTH PROMOTING LIFES
   Wassertheil-Smoller S, 2004, ARCH INTERN MED, V164, P289, DOI 10.1001/archinte.164.3.289
   Whang W, 2009, J AM COLL CARDIOL, V53, P950, DOI 10.1016/j.jacc.2008.10.060
   White ML, 2007, J CARDIOVASC NURS, V22, P138, DOI 10.1097/00005082-200703000-00012
   Wilson PWF, 1998, CIRCULATION, V97, P1837, DOI 10.1161/01.CIR.97.18.1837
   Wulsin LR, 2005, PSYCHOSOM MED, V67, P697, DOI 10.1097/01.psy.0000181274.56785.28
   Wulsin LR, 2003, PSYCHOSOM MED, V65, P201, DOI 10.1097/01.PSY.0000058371.50240.E3
   Ye SQ, 2013, J AM COLL CARDIOL, V61, P622, DOI 10.1016/j.jacc.2012.09.058
   Yusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9
   Ziegelstein RC, 2005, PSYCHOSOM MED, V67, P393, DOI 10.1097/01.psy.0000160475.38930.8d
NR 82
TC 22
Z9 29
U1 0
U2 23
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0889-4655
EI 1550-5049
J9 J CARDIOVASC NURS
JI J. Cardiovasc. Nurs.
PD JUL-AUG
PY 2015
VL 30
IS 4
BP 360
EP 372
DI 10.1097/JCN.0000000000000158
PG 13
WC Cardiac & Cardiovascular Systems; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Nursing
GA CL1PK
UT WOS:000356715800012
PM 24850376
DA 2025-06-11
ER

PT J
AU Bates, R
   Salsberry, P
   Ford, J
AF Bates, Randi
   Salsberry, Pamela
   Ford, Jodi
TI Measuring Stress in Young Children Using Hair Cortisol: The State of the
   Science
SO BIOLOGICAL RESEARCH FOR NURSING
LA English
DT Article
DE hair cortisol; chronic stress; young children
ID ADVERSE CHILDHOOD EXPERIENCES; PITUITARY-ADRENAL AXIS; OF-THE-ART;
   SOCIOECONOMIC-STATUS; FUTURE-DIRECTIONS; DEVELOPMENTAL PATHWAYS; HEALTH
   DEVELOPMENT; METABOLIC SYNDROME; CUSHINGS-SYNDROME; ALLOSTATIC LOAD
AB Extensive literature suggests that adverse experiences in early childhood may deleteriously impact later health. These effects are thought to be related to the impact of persistent or chronic stress on various biological processes, mediated by dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, and ultimately irregularities in cortisol levels. Ameliorating persistent stress in young children requires accurately measuring the chronicity of physiologic stress, which is difficult in young children because of unreliable self-report and the burden and inaccuracy associated with using invasive acute-stress biomeasures. A better way to approximate persistent stress in young children is measuring hair cortisol concentration (HCC), as it only requires one noninvasive collection to measure months of HPA-axis activity or experienced stress. However, few studies measure HCC in young children despite wide use in adult stress research. This article reviews and synthesizes research that uses HCC to approximate persistent stress in healthy children, 12-60 months of age. Reviewed studies indicate that HCC is elevated in young children who are experiencing forms of persistent stress such as low socioeconomic status and maternal distress. Hair cortisol is thus a promising measure of early childhood persistent stress, but due to the limited use of HCC in this population, much research is still needed. Specifically, nurse researchers may need to measure several factors associated with early childhood persistent stress and HCC to identify which children are at risk for stress-related disease.
C1 [Bates, Randi; Ford, Jodi] Ohio State Univ, Coll Nursing, Newton Hall,1585 Neil Ave, Columbus, OH 43210 USA.
   [Salsberry, Pamela] Ohio State Univ, Coll Publ Hlth, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University
RP Bates, R (corresponding author), Ohio State Univ, Coll Nursing, Newton Hall,1585 Neil Ave, Columbus, OH 43210 USA.
EM bates.204@osu.edu
RI Bates, Randi/I-2200-2019; Ford, Jodi/AAO-9830-2021
OI Bates, Randi/0000-0002-6672-8155; Ford, Jodi/0000-0002-0778-4667
FU Crane Center for Early Childhood Research and Policy; Jonas Doctoral
   Nurse Scholar Program
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This
   research received no specific grant from any funding agency in the
   public, commercial, or not-for-profit sectors. Randi Bates is supported
   by a graduate research associateship with the Crane Center for Early
   Childhood Research and Policy and by a scholarship from the Jonas
   Doctoral Nurse Scholar Program.
CR Alegría M, 2008, AM J PSYCHIAT, V165, P359, DOI 10.1176/appi.ajp.2007.07040704
   Anda RF, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-106
   [Anonymous], 2009, Principles and standards for school mathematics, P1
   Ayoub C, 2011, CHILD DEV, V82, P583, DOI 10.1111/j.1467-8624.2010.01549.x
   Baum Andrew., 1997, Measuring stress: A guide for health and social scientists, P175
   Blair C, 2008, DEV PSYCHOL, V44, P1095, DOI 10.1037/0012-1649.44.4.1095
   Blair C, 2006, ANN NY ACAD SCI, V1094, P263, DOI 10.1196/annals.1376.031
   Blair C, 2013, PSYCHONEUROENDOCRINO, V38, P2666, DOI 10.1016/j.psyneuen.2013.06.025
   Blair C, 2011, CHILD DEV, V82, P1970, DOI 10.1111/j.1467-8624.2011.01643.x
   Blair C, 2010, CHILD DEV PERSPECT, V4, P181, DOI 10.1111/j.1750-8606.2010.00145.x
   Bradley E.H. Taylor., 2013, The American Health Care Paradox: Why Spending More Is Getting Us Less
   Briggs-Gowan MJ, 2012, J PEDIATR PSYCHOL, V37, P11, DOI 10.1093/jpepsy/jsr063
   Brody GH, 2013, DEV PSYCHOL, V49, P913, DOI 10.1037/a0028847
   Brooks KP, 2009, PSYCHONEUROENDOCRINO, V34, P1041, DOI 10.1016/j.psyneuen.2009.02.005
   Carter MA, 2013, J URBAN HEALTH, V90, P224, DOI 10.1007/s11524-012-9712-8
   Chen X., 2015, Handbook of child psychology and developmental science pp, P152, DOI [10.1002/9781118963418.childpsy305, DOI 10.1002/9781118963418.CHILDPSY305]
   D'Anna-Hernandez KL, 2011, PHYSIOL BEHAV, V104, P348, DOI 10.1016/j.physbeh.2011.02.041
   Danese A, 2012, PHYSIOL BEHAV, V106, P29, DOI 10.1016/j.physbeh.2011.08.019
   De Leo M, 2012, BEST PRACT RES CL EN, V26, P497, DOI 10.1016/j.beem.2012.02.001
   Dettenborn L, 2010, PSYCHONEUROENDOCRINO, V35, P1404, DOI 10.1016/j.psyneuen.2010.04.006
   Dettenborn L, 2012, STRESS, V15, P348, DOI 10.3109/10253890.2011.619239
   Essex MJ, 2002, BIOL PSYCHIAT, V52, P776, DOI 10.1016/S0006-3223(02)01553-6
   Everly GS., 2002, CLIN GUIDE TREATMENT
   Felitti VJ, 1998, AM J PREV MED, V14, P245, DOI 10.1016/S0749-3797(98)00017-8
   Gow R, 2010, FORENSIC SCI INT, V196, P32, DOI 10.1016/j.forsciint.2009.12.040
   Grass J, 2015, PSYCHONEUROENDOCRINO, V53, P108, DOI 10.1016/j.psyneuen.2014.12.023
   Groeneveld MG, 2013, STRESS, V16, P711, DOI 10.3109/10253890.2013.817553
   Grunau RE, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0073926
   Gunnar MR, 2002, PSYCHONEUROENDOCRINO, V27, P199, DOI 10.1016/S0306-4530(01)00045-2
   Halfon N, 2002, MILBANK Q, V80, P433, DOI 10.1111/1468-0009.00019
   Halfon N, 2014, MATERN CHILD HLTH J, V18, P344, DOI 10.1007/s10995-013-1346-2
   Hamel AF, 2011, CLIN CHIM ACTA, V412, P382, DOI 10.1016/j.cca.2010.10.019
   Hoffman MC, 2014, CLIN INVEST MED, V37, pE252, DOI 10.25011/cim.v37i4.21731
   Hostinar CE, 2013, J CLIN CHILD ADOLESC, V42, P564, DOI 10.1080/15374416.2013.804387
   Kamps AWA, 2014, ACTA PAEDIATR, V103, P957, DOI 10.1111/apa.12685
   Kang DH, 2010, WESTERN J NURS RES, V32, P730, DOI 10.1177/0193945909356556
   Karlén J, 2015, PEDIATRICS, V135, pE1450, DOI 10.1542/peds.2014-2561
   Karlén J, 2013, PEDIATRICS, V132, pE1333, DOI 10.1542/peds.2013-1178
   Kaufman J, 1997, BIOL PSYCHIAT, V42, P669, DOI 10.1016/S0006-3223(96)00470-2
   Kirschbaum C, 2009, PSYCHONEUROENDOCRINO, V34, P32, DOI 10.1016/j.psyneuen.2008.08.024
   Kuehl LK, 2015, PSYCHONEUROENDOCRINO, V51, P365, DOI 10.1016/j.psyneuen.2014.09.012
   Lee DY, 2015, BMB REP, V48, P209, DOI 10.5483/BMBRep.2015.48.4.275
   Lightman SL, 2008, EUR J PHARMACOL, V583, P255, DOI 10.1016/j.ejphar.2007.11.073
   Marshall GN., 1999, A Review of the Scientific Literature As It Pertains to Gulf War Illnesses. Volume 4, V4
   McCoy Dana Charles, 2014, J Child Poverty, V20, P131
   McEwen BS, 2007, PHYSIOL REV, V87, P873, DOI 10.1152/physrev.00041.2006
   McEwen BS, 2010, ANN NY ACAD SCI, V1186, P190, DOI 10.1111/j.1749-6632.2009.05331.x
   Monnat SM, 2015, SOCIOL QUART, V56, P723, DOI 10.1111/tsq.12107
   Monroe SM, 2008, ANNU REV CLIN PSYCHO, V4, P33, DOI 10.1146/annurev.clinpsy.4.022007.141207
   Noppe G, 2014, HORM RES PAEDIAT, V82, P97, DOI 10.1159/000362519
   Palmer FB, 2013, J PEDIATR-US, V163, P1733, DOI 10.1016/j.jpeds.2013.08.030
   Pragst F, 2006, CLIN CHIM ACTA, V370, P17, DOI 10.1016/j.cca.2006.02.019
   Raul JS, 2004, CLIN BIOCHEM, V37, P1105, DOI 10.1016/j.clinbiochem.2004.02.010
   Rothbart M.K., 2011, Becoming who we are: Temperament and personality in development
   Rowe DC, 1999, CHILD DEV, V70, P1151, DOI 10.1111/1467-8624.00084
   Russell E, 2015, THER DRUG MONIT, V37, P71, DOI 10.1097/FTD.0000000000000148
   Russell E, 2014, THER DRUG MONIT, V36, P30, DOI 10.1097/FTD.0b013e31829daa0a
   Russell E, 2012, PSYCHONEUROENDOCRINO, V37, P589, DOI 10.1016/j.psyneuen.2011.09.009
   Sauve B, 2007, CLIN INVEST MED, V30, pE183, DOI 10.25011/cim.v30i5.2894
   Schwartz SJ, 2010, AM PSYCHOL, V65, P237, DOI 10.1037/a0019330
   Shonkoff JP, 2012, P NATL ACAD SCI USA, V109, P17302, DOI 10.1073/pnas.1121259109
   Shonkoff JP, 2012, PEDIATRICS, V129, pE232, DOI 10.1542/peds.2011-2663
   Shonkoff JP, 2010, CHILD DEV, V81, P357, DOI 10.1111/j.1467-8624.2009.01399.x
   Shonkoff JP, 2009, JAMA-J AM MED ASSOC, V301, P2252, DOI 10.1001/jama.2009.754
   Short SJ, 2016, PSYCHONEUROENDOCRINO, V71, P12, DOI 10.1016/j.psyneuen.2016.05.007
   Slominski R, 2015, THER DRUG MONIT, V37, P812, DOI 10.1097/FTD.0000000000000209
   Smith K.J., 1993, Contemporary Accounting Research, V9, P432
   Smy L, 2015, PEDIATR RES, V78, P44, DOI 10.1038/pr.2015.60
   Stalder T, 2013, J CLIN ENDOCR METAB, V98, P2573, DOI 10.1210/jc.2013-1056
   Stalder T, 2012, BRAIN BEHAV IMMUN, V26, P1019, DOI 10.1016/j.bbi.2012.02.002
   Stalder T, 2009, PSYCHONEUROENDOCRINO, V34, P607, DOI 10.1016/j.psyneuen.2008.10.023
   STARKMAN MN, 1992, BIOL PSYCHIAT, V32, P756, DOI 10.1016/0006-3223(92)90079-F
   Steudte S, 2011, PSYCHIAT RES, V186, P310, DOI 10.1016/j.psychres.2010.09.002
   Steudte-Schmiedgen S, 2015, PSYCHONEUROENDOCRINO, V59, P123, DOI 10.1016/j.psyneuen.2015.05.007
   Tottenham N, 2010, DEVELOPMENTAL SCI, V13, P46, DOI 10.1111/j.1467-7687.2009.00852.x
   Tsigos C, 2002, J PSYCHOSOM RES, V53, P865, DOI 10.1016/S0022-3999(02)00429-4
   Vaghri Z, 2013, PSYCHONEUROENDOCRINO, V38, P331, DOI 10.1016/j.psyneuen.2012.06.009
   Vanaelst B, 2012, PSYCHOPHYSIOLOGY, V49, P1072, DOI 10.1111/j.1469-8986.2012.01396.x
   Vliegenthart J, 2016, PSYCHONEUROENDOCRINO, V65, P9, DOI 10.1016/j.psyneuen.2015.11.022
   Watamura SE, 2004, DEV PSYCHOBIOL, V45, P125, DOI 10.1002/dev.20026
   Wennig R, 2000, FORENSIC SCI INT, V107, P5, DOI 10.1016/S0379-0738(99)00146-2
   Wodtke GT, 2013, DEMOGRAPHY, V50, P1765, DOI 10.1007/s13524-013-0219-z
   World Health Organization, 2005, Preventing chronic diseases: a vital investment: WHO global report
   Wust Stefan, 2000, Noise Health, V2, P79
   Yamada J, 2007, NEONATOLOGY, V92, P42, DOI 10.1159/000100085
   Ziol-Guest KM, 2014, CHILD DEV, V85, P103, DOI 10.1111/cdev.12105
NR 86
TC 72
Z9 79
U1 0
U2 31
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1099-8004
EI 1552-4175
J9 BIOL RES NURS
JI Biol. Res. Nurs.
PD OCT
PY 2017
VL 19
IS 5
BP 499
EP 510
DI 10.1177/1099800417711583
PG 12
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA FQ2IU
UT WOS:000418180900003
PM 28617035
OA Green Published
DA 2025-06-11
ER

PT J
AU Das, UN
AF Das, UN
TI Long-chain polyunsaturated fatty acids interact with nitric oxide,
   superoxide anion, and transforming growth factor-β to prevent human
   essential hypertension
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Review
DE long-chain polyunsaturated fatty acids; hypertension; angiotensin
   converting enzyme; nitric oxide; eicosapentaenoic acid; Docosahexaenoic
   acid
ID CONVERTING ENZYME-INHIBITOR; ENDOTHELIUM-DEPENDENT VASODILATION;
   METABOLIC SYNDROME-X; LATER BLOOD-PRESSURE; SMOOTH-MUSCLE-CELLS;
   ANGIOTENSIN-II; CALCIUM-ANTAGONIST; DIABETES-MELLITUS; OXIDATIVE STRESS;
   L-ARGININE
AB Patients with uncontrolled essential hypertension have elevated concentrations of superoxide anion (O-2(-circle)), hydrogen peroxide (H2O2), lipid peroxides, endothelin, and transforming growth factor-beta (TGF-beta) with a simultaneous decrease in endothelial nitric oxide (eNO), superoxide dismutase (SOD), vitamin E, and long-chain polyunsaturated fatty acids (LCPUFAs). Physiological concentrations of angiotensin II activate NAD(P) H oxidase and trigger free radical generation (especially that of O-2(-circle)). Normally, angiotensin II-induced oxidative stress is abrogated by adequate production and release of eNO, which quenches O-2(-circle) to restore normotension. Angiotensin II also stimulates the production of endothelin and TGF-beta. TGF-beta enhances NO generation, which in turn suppresses TGF-beta production. Thus, NO has a regulatory role on TGF-beta production and is also a physiological antagonist of endothelin. Antihypertensive drugs suppress the production of O-2(-circle) K and TGF-beta and enhance eNO synthesis to bring about their beneficial actions. LCPUFAs suppress angiotensin-converting enzyme (ACE) activity, reduce angiotensin II formation, enhance eNO generation, and suppress TGF-beta expression. Perinatal supplementation of LCPUFAs decreases insulin resistance and prevents the development of hypertension in adult life, whereas deficiency of LCPUFAs in the perinatal period results in raised blood pressure later in life. Patients with essential hypertension have low concentrations of various LCPUFAs in their plasma phospholipid fraction. Based on this, it is proposed that LCPUFAs serve as endogenous regulators of ACE activity, O-2(-circle), eNO generation, and TGF-beta expression. Further, LCPUFAs have actions similar to statins, inhibit (especially omega-3 fatty acids) cyclooxygenase activity and suppress the synthesis of proinflammatory cytokines, and activate the parasympathetic nervous system, all actions that reduce the risk of major vascular events. Hence, it is proposed that availability of adequate amounts of LCPUFAs during the critical periods of growth prevents the development of hypertension in adulthood.
C1 EFA Sci LLC, Norwood, MA 02062 USA.
RP EFA Sci LLC, 1420 Prov Highway,Suite 266, Norwood, MA 02062 USA.
EM undas@efasciences.com
RI Das, Undurti/A-7918-2009
CR Agarwal R, 2002, AM J KIDNEY DIS, V39, P486, DOI 10.1053/ajkd.2002.31392
   BACHMANN S, 1994, AM J KIDNEY DIS, V24, P112, DOI 10.1016/S0272-6386(12)80170-3
   Baur LA, 1998, METABOLISM, V47, P106, DOI 10.1016/S0026-0495(98)90202-5
   Bayorh MA, 1999, CLIN EXP HYPERTENS, V21, P333, DOI 10.3109/10641969909068669
   Beswick RA, 2001, HYPERTENSION, V38, P1107, DOI 10.1161/hy1101.093423
   Böger RH, 1998, CIRCULATION, V98, P1842, DOI 10.1161/01.CIR.98.18.1842
   Camilletti A, 2001, AM J HYPERTENS, V14, P382, DOI 10.1016/S0895-7061(00)01297-8
   Campese VM, 1997, J HUM HYPERTENS, V11, P527, DOI 10.1038/sj.jhh.1000485
   Cardillo C, 1998, CIRCULATION, V97, P851, DOI 10.1161/01.CIR.97.9.851
   Carneado J, 2002, J HYPERTENS, V20, P429, DOI 10.1097/00004872-200203000-00018
   Chabrashvili T, 2002, HYPERTENSION, V39, P269, DOI 10.1161/hy0202.103264
   Craven PA, 1997, DIABETES, V46, P671, DOI 10.2337/diabetes.46.4.671
   Das U N, 1999, J Assoc Physicians India, V47, P906
   Das U.N., 2002, A perinatal strategy for preventing adult disease: the role of long-chain polyunsaturated fatty acids: the role of long-chain polyunsaturated fatty acids
   DAS UN, 1987, MED SCI RES-BIOCHEM, V15, P1485
   DAS UN, 1985, IRCS MED SCI-BIOCHEM, V13, P684
   DAS UN, 1991, ASIA PAC J PHARMACOL, V6, P317
   DAS UN, 1988, NUTRITION, V4, P337
   Das UN, 2000, LANCET, V355, P1273, DOI 10.1016/S0140-6736(05)74701-2
   Das UN, 2002, NUTRITION, V18, P774, DOI 10.1016/S0899-9007(02)00826-2
   Das UN, 2002, NUTRITION, V18, P430, DOI 10.1016/S0899-9007(01)00747-X
   DAS UN, 1995, PROSTAG LEUKOTR ESS, V52, P387, DOI 10.1016/0952-3278(95)90066-7
   Das UN, 2001, NUTRITION, V17, P953, DOI 10.1016/S0899-9007(01)00672-4
   Das UN, 2001, PROSTAG LEUKOTR ESS, V65, P37, DOI 10.1054/plef.2001.0285
   Das UN, 2001, CAN MED ASSOC J, V165, P13
   Das UN, 2000, PROSTAG LEUKOTR ESS, V63, P351, DOI 10.1054/plef.2000.0226
   Das UN, 2001, NUTRITION, V17, P260, DOI 10.1016/S0899-9007(00)00578-5
   Das UN, 2001, NUTRITION, V17, P337, DOI 10.1016/S0899-9007(00)00586-4
   Das UN, 2001, HYPERTENSION, V38, pE6, DOI 10.1161/hy0901.095926
   DAS UN, 1994, PROSTAG LEUKOTR ESS, V50, P253, DOI 10.1016/0952-3278(94)90163-5
   Delles C, 2002, KIDNEY INT, V61, P1462, DOI 10.1046/j.1523-1755.2002.00260.x
   Derhaschnig U, 2002, AM J HYPERTENS, V15, P207, DOI 10.1016/S0895-7061(01)02327-5
   DHALY AJ, 2002, AM J PHYSIOL-REG I, V283, pR757
   DIEDERICH D, 1994, HYPERTENSION, V23, P957, DOI 10.1161/01.HYP.23.6.957
   El Midaoui A, 2002, J HYPERTENS, V20, P1407, DOI 10.1097/00004872-200207000-00028
   Esmatjes E, 2001, NEPHROL DIAL TRANSPL, V16, P90, DOI 10.1093/ndt/16.suppl_1.90
   Fakhouri F, 2001, J AM SOC NEPHROL, V12, P2701, DOI 10.1681/ASN.V12122701
   Fujiwara N, 2000, CIRCULATION, V101, P856, DOI 10.1161/01.CIR.101.8.856
   González-Santiago L, 2000, J LAB CLIN MED, V136, P395, DOI 10.1067/mlc.2000.110370
   Guzik TJ, 2002, HYPERTENSION, V39, P1088, DOI 10.1161/01.HYP.0000018041.48432.B5
   Hamilton CA, 2001, HYPERTENSION, V37, P529, DOI 10.1161/01.HYP.37.2.529
   HAYNES WG, 1993, J HYPERTENS, V11, P1375, DOI 10.1097/00004872-199312000-00009
   Houlihan CA, 2002, DIABETES CARE, V25, P1072, DOI 10.2337/diacare.25.6.1072
   INOUE N, 1995, ARTERIOSCL THROM VAS, V15, P1255, DOI 10.1161/01.ATV.15.8.1255
   Jain S, 2001, RENAL FAILURE, V23, P651, DOI 10.1081/JDI-100107361
   Jun T, 1996, J HUM HYPERTENS, V10, P305
   Kaehler A, 2002, CLIN SCI, V103, p176S, DOI 10.1042/CS103S176S
   KATUSIC ZS, 1989, AM J PHYSIOL, V257, pH33, DOI 10.1152/ajpheart.1989.257.1.H33
   Kitamoto S, 2000, J HYPERTENS, V18, P1795, DOI 10.1097/00004872-200018120-00013
   Kohno M, 1999, METABOLISM, V48, P1256, DOI 10.1016/S0026-0495(99)90264-0
   KOIDE M, 1994, HYPERTENSION, V23, pI45, DOI 10.1161/01.HYP.23.1_Suppl.I45
   KUMAR GS, 1994, PROSTAG LEUKOTR ESS, V50, P331
   Kumar KV, 1997, P SOC EXP BIOL MED, V214, P374, DOI 10.3181/00379727-214-44106
   KUMAR KV, 1993, FREE RADICAL RES COM, V19, P59, DOI 10.3109/10715769309056499
   Lagadec P, 1999, AM J PATHOL, V154, P1867, DOI 10.1016/S0002-9440(10)65444-2
   McAllister AS, 1999, CLIN SCI, V97, P141, DOI 10.1042/CS19980280
   MCCARRON DA, 1984, SCIENCE, V224, P1392, DOI 10.1126/science.6729459
   MCVEIGH GE, 1993, DIABETOLOGIA, V36, P33, DOI 10.1007/BF00399090
   Miyazaki M, 2000, BBA-MOL CELL BIOL L, V1483, P101, DOI 10.1016/S1388-1981(99)00180-8
   Mohan IK, 2000, PROSTAG LEUKOTR ESS, V62, P35
   Mohan IK, 2001, NUTRITION, V17, P126, DOI 10.1016/S0899-9007(00)00468-8
   Morawietz H, 2001, BIOCHEM BIOPH RES CO, V285, P1130, DOI 10.1006/bbrc.2001.5312
   Nakanishi K, 2002, AM J HYPERTENS, V15, P150, DOI 10.1016/S0895-7061(01)02267-1
   Nakayama M, 1999, J HYPERTENS, V17, P1421, DOI 10.1097/00004872-199917100-00009
   NAKAZONO K, 1991, P NATL ACAD SCI USA, V88, P10045, DOI 10.1073/pnas.88.22.10045
   On YK, 2002, HYPERTENS RES, V25, P365, DOI 10.1291/hypres.25.365
   Passmore JC, 1997, J LAB CLIN MED, V130, P627, DOI 10.1016/S0022-2143(97)90112-8
   Rey FE, 2001, CIRC RES, V89, P408, DOI 10.1161/hh1701.096037
   Riser BL, 1998, J AM SOC NEPHROL, V9, P827
   Russo LM, 2002, HYPERTENSION, V39, P281, DOI 10.1161/hy0202.104266
   Schmidt RJ, 2001, AM J KIDNEY DIS, V37, P900, DOI 10.1016/S0272-6386(05)80004-6
   Shin GT, 1998, TRANSPLANTATION, V65, P313, DOI 10.1097/00007890-199802150-00003
   Singhal A, 2001, LANCET, V357, P413, DOI 10.1016/S0140-6736(00)04004-6
   Smith APL, 2002, NITRIC OXIDE-BIOL CH, V6, P153, DOI 10.1006/niox.2001.0400
   Somers M J, 1999, Curr Hypertens Rep, V1, P102, DOI 10.1007/s11906-999-0080-z
   Studer RK, 1999, ARTHRITIS RHEUM-US, V42, P248, DOI 10.1002/1529-0131(199902)42:2<248::AID-ANR6>3.0.CO;2-S
   Stys T, 1998, J PHYSIOL PHARMACOL, V49, P37
   Surdacki A, 1999, J CARDIOVASC PHARM, V33, P652, DOI 10.1097/00005344-199904000-00020
   SURYAPRABHA P, 1990, PROSTAGLANDINS LEUKO, V41, P27, DOI DOI 10.1016/0952-3278(90)90127-7
   Suthanthiran M, 2000, P NATL ACAD SCI USA, V97, P3479, DOI 10.1073/pnas.050420897
   Taddei S, 1998, CIRCULATION, V97, P2222, DOI 10.1161/01.CIR.97.22.2222
   Taddei S, 2001, HYPERTENSION, V37, P943, DOI 10.1161/01.HYP.37.3.943
   Taddei S, 1996, CIRCULATION, V94, P1298, DOI 10.1161/01.CIR.94.6.1298
   TADDEI S, 1994, HYPERTENSION, V23, P485, DOI 10.1161/01.HYP.23.4.485
   Taddei S, 2001, HYPERTENSION, V38, P274, DOI 10.1161/01.HYP.38.2.274
   Taittonen L, 1996, PEDIATR RES, V40, P627, DOI 10.1203/00006450-199610000-00019
   Takahashi H, 1995, Hypertens Res, V18, P319, DOI 10.1291/hypres.18.319
   Takase H, 2000, ARZNEIMITTELFORSCH, V50, P530
   Touyz RM, 2001, J HYPERTENS, V19, P1245, DOI 10.1097/00004872-200107000-00009
   Trachtman H, 1998, RES COMMUN MOL PATH, V100, P213
   Valkonen VP, 2001, LANCET, V358, P2127, DOI 10.1016/S0140-6736(01)07184-7
   Vallance P, 2001, LANCET, V358, P2096, DOI 10.1016/S0140-6736(01)07229-4
   Weisinger HS, 2001, NAT MED, V7, P258, DOI 10.1038/85354
   Williams G, 1996, AM J PHYSIOL-REG I, V270, pR145, DOI 10.1152/ajpregu.1996.270.1.R145
   Wilson AC, 1998, BMJ-BRIT MED J, V316, P21, DOI 10.1136/bmj.316.7124.21
   Wolf G, 1998, MINER ELECTROL METAB, V24, P174, DOI 10.1159/000057367
   Wolf G, 2000, Curr Hypertens Rep, V2, P167, DOI 10.1007/s11906-000-0078-z
   Wong VY, 2001, BRIT J PHARMACOL, V134, P977, DOI 10.1038/sj.bjp.0704329
   Yamada Y, 2002, J HUM GENET, V47, P243, DOI 10.1007/s100380200033
   YING WZ, 1999, AM J PHYSL 2, V277, pH1298
   Zalba G, 2001, HYPERTENSION, V38, P1395, DOI 10.1161/hy1201.099611
   Zhang H, 1999, CARDIOVASC RES, V44, P215, DOI 10.1016/S0008-6363(99)00183-2
   Zoccali C, 2001, LANCET, V358, P2113, DOI 10.1016/S0140-6736(01)07217-8
NR 103
TC 88
Z9 96
U1 1
U2 5
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0954-3007
EI 1476-5640
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD FEB
PY 2004
VL 58
IS 2
BP 195
EP 203
DI 10.1038/sj.ejcn.1601766
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 768CZ
UT WOS:000188511800001
PM 14749737
DA 2025-06-11
ER

PT J
AU Cazac, GD
   Lacatusu, CM
   Mihai, C
   Grigorescu, ED
   Onofriescu, A
   Mihai, BM
AF Cazac, Georgiana-Diana
   Lacatusu, Cristina-Mihaela
   Mihai, Catalina
   Grigorescu, Elena-Daniela
   Onofriescu, Alina
   Mihai, Bogdan-Mircea
TI New Insights into Non-Alcoholic Fatty Liver Disease and Coronary Artery
   Disease: The Liver-Heart Axis
SO LIFE-BASEL
LA English
DT Review
DE non-alcoholic fatty liver disease; coronary artery disease;
   cardiovascular risk; liver-heart axis
ID SERUM ALKALINE-PHOSPHATASE; STATES NATIONAL-HEALTH; METABOLIC SYNDROME;
   SUBCLINICAL ATHEROSCLEROSIS; CARDIOVASCULAR RISK; ENDOTHELIAL
   DYSFUNCTION; AMERICAN ASSOCIATION; HEPATIC STEATOSIS; PRACTICE GUIDANCE;
   PROGNOSTIC VALUE
AB Non-alcoholic fatty liver disease (NAFLD) represents the hepatic expression of the metabolic syndrome and is the most prevalent liver disease. NAFLD is associated with liver-related and extrahepatic morbi-mortality. Among extrahepatic complications, cardiovascular disease (CVD) is the primary cause of mortality in patients with NAFLD. The most frequent clinical expression of CVD is the coronary artery disease (CAD). Epidemiological data support a link between CAD and NAFLD, underlain by pathogenic factors, such as the exacerbation of insulin resistance, genetic phenotype, oxidative stress, atherogenic dyslipidemia, pro-inflammatory mediators, and gut microbiota. A thorough assessment of cardiovascular risk and identification of all forms of CVD, especially CAD, are needed in all patients with NAFLD regardless of their metabolic status. Therefore, this narrative review aims to examine the available data on CAD seen in patients with NAFLD, to outline the main directions undertaken by the CVD risk assessment and the multiple putative underlying mechanisms implicated in the relationship between CAD and NAFLD, and to raise awareness about this underestimated association between two major, frequent and severe diseases.
C1 [Cazac, Georgiana-Diana; Lacatusu, Cristina-Mihaela; Grigorescu, Elena-Daniela; Onofriescu, Alina; Mihai, Bogdan-Mircea] Grigore T Popa Univ Med & Pharm, Unit Diabet Nutr & Metab Dis, Iasi 700115, Romania.
   [Cazac, Georgiana-Diana; Lacatusu, Cristina-Mihaela; Onofriescu, Alina; Mihai, Bogdan-Mircea] St Spiridon Cty Clin Emergency Hosp, Clin Ctr Diabet Nutr & Metab Dis, Iasi 700111, Romania.
   [Mihai, Catalina] Sf Spiridon Emergency Hosp, Inst Gastroenterol & Hepatol, Iasi 700111, Romania.
   [Mihai, Catalina] Grigore T Popa Univ Med & Pharm, Unit Med Semiol & Gastroenterol, Iasi 700115, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy; Grigore T Popa University of Medicine & Pharmacy
RP Lacatusu, CM; Grigorescu, ED (corresponding author), Grigore T Popa Univ Med & Pharm, Unit Diabet Nutr & Metab Dis, Iasi 700115, Romania.; Lacatusu, CM (corresponding author), St Spiridon Cty Clin Emergency Hosp, Clin Ctr Diabet Nutr & Metab Dis, Iasi 700111, Romania.
EM cristina.lacatusu@umfiasi.ro; elena-daniela-gh-grigorescu@umfiasi.ro
RI Mihai, Bogdan-Mircea/GMX-0613-2022; Onofriescu, Alina/IAQ-3459-2023;
   Grigorescu, Elena-Daniela/IAP-0871-2023; Mihai, Catalina/AAV-5234-2020;
   Cazac-Panaite, Georgiana-Diana/GQA-5703-2022; Lacatusu, Cristina
   Mihaela/AAE-5515-2022
OI Mihai, Catalina/0000-0001-9375-9224; Cazac-Panaite,
   Georgiana-Diana/0000-0002-6993-5491; Mihai, Bogdan/0000-0003-0413-026X;
   Lacatusu, Cristina Mihaela/0000-0002-9012-5901; GRIGORESCU,
   ELENA-DANIELA/0000-0002-7721-554X
CR Açikel M, 2009, ANATOL J CARDIOL, V9, P273
   Agaç MT, 2013, ANGIOLOGY, V64, P604, DOI 10.1177/0003319713479155
   Agarwal A K, 2011, J Assoc Physicians India, V59, P351
   Akabame S, 2008, CIRC J, V72, P618
   Al Rifai M, 2015, ATHEROSCLEROSIS, V239, P629, DOI 10.1016/j.atherosclerosis.2015.02.011
   Alexander M, 2019, BMJ-BRIT MED J, V367, DOI 10.1136/bmj.l5367
   Aneni EC, 2020, AM J PREVENT CARDIOL, V4, DOI 10.1016/j.ajpc.2020.100097
   [Anonymous], 2015, J HEPATOL, V63, P237, DOI 10.1016/j.jhep.2015.04.006
   Arslan U, 2007, CORONARY ARTERY DIS, V18, P433, DOI 10.1097/MCA.0b013e3282583c0d
   Arslan U, 2012, J CARDIOL, V60, P210, DOI 10.1016/j.jjcc.2012.05.003
   Assy N, 2010, RADIOLOGY, V254, P393, DOI 10.1148/radiol.09090769
   Athyros VG, 2010, LANCET, V376, P1916, DOI 10.1016/S0140-6736(10)61272-X
   Baars T, 2022, METABOLISM, V130, DOI 10.1016/j.metabol.2022.155179
   Bae YS, 2020, CAN J GASTROENTEROL, V2020, DOI 10.1155/2020/8820445
   Baharvand-Ahmadi B, 2016, ARYA ATHEROSCLER, V12, P201
   Ballestri S, 2013, METAB SYNDR RELAT D, V11, P289, DOI 10.1089/met.2012.0149
   Baratta F, 2020, CLIN GASTROENTEROL H, V18, P2324, DOI 10.1016/j.cgh.2019.12.026
   Berzigotti A, 2021, J HEPATOL, V75, P659, DOI 10.1016/j.jhep.2021.05.025
   Bisaccia G, 2020, SAGE OPEN MED, V8, DOI 10.1177/2050312120933804
   Brouwers MCGJ, 2020, DIABETOLOGIA, V63, P253, DOI 10.1007/s00125-019-05024-3
   Cao YX, 2020, J LIPID RES, V61, P1254, DOI 10.1194/jlr.RA120000746
   Carter J, 2022, RADIOL-CARDIOTHORAC, V4, DOI 10.1148/ryct.210260
   Caturano A, 2021, PROCESSES, V9, DOI 10.3390/pr9010135
   Cernea S, 2018, DIABETES-METAB RES, V34, DOI 10.1002/dmrr.3050
   Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI 10.1002/hep.29367
   Chang Y, 2019, AM J GASTROENTEROL, V114, P620, DOI 10.14309/ajg.0000000000000074
   Chen CC, 2021, MEDICINA-LITHUANIA, V57, DOI 10.3390/medicina57080807
   Cheng YT, 2015, HEPAT MON, V15, DOI 10.5812/hepatmon.26818
   Cheung BMY, 2009, INT J CARDIOL, V135, P156, DOI 10.1016/j.ijcard.2008.03.039
   Chhabra R, 2013, MAYO CLIN PROC, V88, P1259, DOI 10.1016/j.mayocp.2013.06.025
   Choi DH, 2013, WORLD J GASTROENTERO, V19, P6453, DOI 10.3748/wjg.v19.i38.6453
   Nguyen CC, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-02144-y
   Cotter TG, 2020, GASTROENTEROLOGY, V158, P1851, DOI 10.1053/j.gastro.2020.01.052
   Dallio M, 2017, J GASTROINTEST LIVER, V26, P261, DOI 10.15403/jgld.2014.1121.263.dal
   Deprince A, 2020, MOL METAB, V42, DOI 10.1016/j.molmet.2020.101092
   Dong MZ, 2021, J INT MED RES, V49, DOI 10.1177/03000605211019263
   Dongiovanni P, 2021, EUR J CLIN INVEST, V51, DOI 10.1111/eci.13519
   Duell PB, 2022, ARTERIOSCL THROM VAS, V42, pE168, DOI 10.1161/ATV.0000000000000153
   EASL, 2016, OBESITY FACTS, V9, P65, DOI [10.1159/000443344, 10.1007/s00125-016-3902-y, 10.1016/j.jhep.2015.11.004]
   Efe D, 2014, ARQ BRAS CARDIOL, V102, P10, DOI 10.5935/abc.20130225
   Elsheikh E, 2014, J GASTROEN HEPATOL, V29, P1528, DOI 10.1111/jgh.12549
   Eslam M, 2020, J HEPATOL, V73, P202, DOI 10.1016/j.jhep.2020.03.039
   Eslam M, 2020, GASTROENTEROLOGY, V158, P1999, DOI 10.1053/j.gastro.2019.11.312
   Fernández-Friera L, 2017, J AM COLL CARDIOL, V70, P2979, DOI 10.1016/j.jacc.2017.10.024
   Fiorentino TV, 2020, DIABETES-METAB RES, V36, DOI 10.1002/dmrr.3333
   Fortuño A, 2002, ENDOCRINOLOGY, V143, P3555, DOI 10.1210/en.2002-220075
   Francque SM, 2016, J HEPATOL, V65, P425, DOI 10.1016/j.jhep.2016.04.005
   Frühbeck G, 2003, DIABETOLOGIA, V46, P143, DOI 10.1007/s00125-003-1053-4
   Gariani K, 2021, ENDOCR CONNECT, V10, pR52, DOI 10.1530/EC-20-0490
   Gaudio E, 2012, INTERN EMERG MED, V7, pS297, DOI 10.1007/s11739-012-0826-5
   Golabi Pegah, 2019, Clin Diabetes, V37, P65, DOI 10.2337/cd18-0026
   Gómez-Ambrosi J, 2017, CLIN NUTR, V36, P861, DOI 10.1016/j.clnu.2016.04.027
   Gummesson A, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0202666
   Gurel H, 2016, EUR REV MED PHARMACO, V20, P4305
   Haddad TM, 2017, DIAB MET SYND CLIN R, V11, pS209, DOI 10.1016/j.dsx.2016.12.033
   Hao YP, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0072345
   Honda Y, 2016, HEPATOL RES, V46, P1011, DOI 10.1111/hepr.12648
   Hsieh CJ, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0127521
   Hsu PF, 2021, LIVER INT, V41, P81, DOI 10.1111/liv.14637
   Ichikawa K, 2022, EUR J PREV CARDIOL, V28, P2059, DOI 10.1093/eurjpc/zwab120
   Ichikawa K, 2021, CARDIOVASC DIABETOL, V20, DOI 10.1186/s12933-020-01192-4
   Idilman IS, 2015, J DIABETES, V7, P279, DOI 10.1111/1753-0407.12172
   Ismael H., 2020, INT J CLIN MED, V11, P182, DOI [10.4236/ijcm.2020.114018, DOI 10.4236/IJCM.2020.114018]
   Ismaiel A, 2019, FRONT MED-LAUSANNE, V6, DOI 10.3389/fmed.2019.00202
   Jacobs K, 2016, CLIN GASTROENTEROL H, V14, P1337, DOI 10.1016/j.cgh.2016.01.010
   Jana S.B., 2020, J MED SCI CLIN RES, V8, P4688, DOI [10.18535/jmscr/v8i4.30, DOI 10.18535/JMSCR/V8I4.30]
   Jeon WS, 2013, ENDOCRINOL METAB, V28, P283, DOI 10.3803/EnM.2013.28.4.283
   Jose N, 2021, CUREUS J MED SCIENCE, V13, DOI 10.7759/cureus.20515
   Josef P, 2013, INT J ENV RES PUB HE, V10, P3409, DOI 10.3390/ijerph10083409
   Juárez-Rojas JG, 2013, DIABETES CARE, V36, P1726, DOI 10.2337/dc12-1276
   Kang MK, 2015, YONSEI MED J, V56, P1288, DOI 10.3349/ymj.2015.56.5.1288
   Kang SH, 2021, CLIN MOL HEPATOL, V27, P257, DOI 10.3350/cmh.2021.0067
   Karlsson FH, 2012, NAT COMMUN, V3, DOI 10.1038/ncomms2266
   Kasper P, 2021, CLIN RES CARDIOL, V110, P921, DOI 10.1007/s00392-020-01709-7
   Kerut SE, 2017, ECHOCARDIOGR-J CARD, V34, P937, DOI 10.1111/echo.13545
   Keskin M, 2017, AM J CARDIOL, V120, P1720, DOI 10.1016/j.amjcard.2017.07.107
   Khashper A, 2013, INT J CARDIOL, V162, P184, DOI 10.1016/j.ijcard.2011.05.059
   Kim BJ, 2016, J CLIN LIPIDOL, V10, P1423, DOI 10.1016/j.jacl.2016.09.007
   Kim D, 2012, HEPATOLOGY, V56, P605, DOI 10.1002/hep.25593
   Kim MK, 2015, MENOPAUSE, V22, P1323, DOI 10.1097/GME.0000000000000503
   Kim Y, 2022, GUT LIVER, V16, P290, DOI 10.5009/gnl210084
   Koo BK, 2020, J VASC SURG, V71, P204, DOI 10.1016/j.jvs.2019.03.044
   Kotronen A, 2008, ARTERIOSCL THROM VAS, V28, P27, DOI 10.1161/ATVBAHA.107.147538
   Kuchay MS, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9101346
   Kumar R, 2017, J CLIN TRANSL HEPATO, V5, P216, DOI 10.14218/JCTH.2016.00068
   Kunutsor SK, 2015, J HYPERTENS, V33, P2373, DOI 10.1097/HJH.0000000000000763
   Langroudi TF, 2018, ROM J INTERN MED, V56, P167, DOI 10.2478/rjim-2018-0009
   Lee CH, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.638615
   Lee CH, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.116.005344
   Lee CO, 2021, ANN MED, V53, P1065, DOI 10.1080/07853890.2021.1943514
   Lee MK, 2015, CARDIOVASC DIABETOL, V14, DOI 10.1186/s12933-015-0253-9
   Lee SB, 2018, J HEPATOL, V68, P1018, DOI 10.1016/j.jhep.2017.12.012
   Lee YH, 2019, DIABETES METAB J, V43, P31, DOI 10.4093/dmj.2019.0011
   Li XL, 2016, LIPIDS HEALTH DIS, V15, DOI 10.1186/s12944-016-0221-8
   Li XM, 2012, ATHEROSCLEROSIS, V224, P480, DOI 10.1016/j.atherosclerosis.2012.07.002
   Lim S, 2011, RADIOLOGY, V261, P437, DOI 10.1148/radiol.11101725
   Liu CJ, 2012, J GASTROEN HEPATOL, V27, P1555, DOI 10.1111/j.1440-1746.2012.07222.x
   Liu H, 2014, WORLD J GASTROENTERO, V20, P8407, DOI 10.3748/wjg.v20.i26.8407
   Liu HH, 2019, CLIN TRANSL GASTROEN, V10, DOI 10.14309/ctg.0000000000000011
   Long MT, 2021, HEPATOLOGY, V73, P548, DOI 10.1002/hep.31608
   Lu FB, 2020, J GASTROEN HEPATOL, V35, P2041, DOI 10.1111/jgh.15156
   Luo J, 2015, EUR J GASTROEN HEPAT, V27, P193, DOI 10.1097/MEG.0000000000000254
   Magalhaes RD, 2021, CLIN RES HEPATOL GAS, V45, DOI 10.1016/j.clinre.2020.11.010
   Marusic M, 2021, CAN J GASTROENTEROL, V2021, DOI 10.1155/2021/6613827
   Mehta R, 2016, BMJ OPEN GASTROENTER, V3, DOI 10.1136/bmjgast-2016-000096
   Meyersohn NM, 2021, CLIN GASTROENTEROL H, V19, P1480, DOI 10.1016/j.cgh.2020.07.030
   Niederseer D, 2020, J CLIN MED, V9, DOI 10.3390/jcm9041065
   Niikura T, 2020, DIAGNOSTICS, V10, DOI 10.3390/diagnostics10030129
   Olubamwo OO, 2018, EUR J GASTROEN HEPAT, V30, P1047, DOI 10.1097/MEG.0000000000001183
   Oni E, 2019, AM J CARDIOL, V124, P534, DOI 10.1016/j.amjcard.2019.05.028
   Oni ET, 2013, ATHEROSCLEROSIS, V230, P258, DOI 10.1016/j.atherosclerosis.2013.07.052
   Osawa K, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0131138
   Otsuka F, 2007, CIRC J, V71, P1703, DOI 10.1253/circj.71.1703
   Arab JP, 2020, ANN HEPATOL, V19, P674, DOI 10.1016/j.aohep.2020.09.006
   Pais R, 2019, HEPATOLOGY, V69, P1453, DOI 10.1002/hep.30223
   Park GM, 2015, INT J CARDIOVAS IMAG, V31, P659, DOI 10.1007/s10554-015-0587-0
   Park HE, 2019, J GASTROENTEROL, V54, P271, DOI 10.1007/s00535-018-1516-5
   Park HE, 2016, J CLIN ENDOCR METAB, V101, P3134, DOI 10.1210/jc.2016-1525
   Persico M, 2017, BMC GASTROENTEROL, V17, DOI 10.1186/s12876-017-0592-y
   Przybyszewski Eric M, 2021, Clin Liver Dis (Hoboken), V17, P19, DOI 10.1002/cld.1017
   Puchner SB, 2015, RADIOLOGY, V274, P693, DOI 10.1148/radiol.14140933
   Pulido MR, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0022931
   Pulimaddi R., 2016, INT ARCH INTEGR MED, V3, P118
   Ridker PM, 2017, NEW ENGL J MED, V377, P1119, DOI 10.1056/NEJMoa1707914
   Roberts AB, 2018, NAT MED, V24, P1407, DOI 10.1038/s41591-018-0128-1
   Saraya S, 2021, EGYPT HEART J, V73, DOI 10.1186/s43044-021-00222-0
   Schindhelm RK, 2007, ATHEROSCLEROSIS, V191, P391, DOI 10.1016/j.atherosclerosis.2006.04.006
   Semmler G, 2021, CLIN TRANSL GASTROEN, V12, DOI 10.14309/ctg.0000000000000326
   Shah RV, 2017, JACC-CARDIOVASC IMAG, V10, P1016, DOI 10.1016/j.jcmg.2016.10.024
   Silva ACSE, 2017, WORLD J GASTROENTERO, V23, P3396, DOI 10.3748/wjg.v23.i19.3396
   Simon TG, 2018, INT J CARDIOL, V259, P198, DOI 10.1016/j.ijcard.2018.01.046
   Simons N, 2017, GASTROENTEROLOGY, V152, P912, DOI 10.1053/j.gastro.2016.12.020
   Sinn DH, 2017, GUT, V66, P323, DOI 10.1136/gutjnl-2016-311854
   Song D, 2019, GUT LIVER, V13, P658, DOI 10.5009/gnl18439
   Sung KC, 2009, ATHEROSCLEROSIS, V203, P581, DOI 10.1016/j.atherosclerosis.2008.07.024
   Sung KC, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-162
   Sung KC, 2012, DIABETES CARE, V35, P2359, DOI 10.2337/dc12-0515
   Tang A., 2022, Clinical Gastroenterol Hepatol, DOI 10.1016/j.cgh.2022.06.029
   Tang CS, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms10206
   Targher G, 2021, LANCET GASTROENTEROL, V6, pS78, DOI 10.1016/S2468-1253(21)00020-0
   Targher G, 2021, DIABETES METAB, V47, DOI 10.1016/j.diabet.2020.101215
   Targher G, 2020, GUT, V69, P1691, DOI 10.1136/gutjnl-2020-320622
   Thevenot T, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0266965
   Thomsen C, 2016, EUR HEART J-CARD IMG, V17, P120, DOI 10.1093/ehjci/jev325
   Toh JZK, 2022, CLIN GASTROENTEROL H, V20, P2462, DOI 10.1016/j.cgh.2021.09.021
   Treeprasertsuk S, 2011, DIGEST DIS SCI, V56, P35, DOI 10.1007/s10620-010-1241-2
   van Veelen A, 2022, J CLIN MED, V11, DOI 10.3390/jcm11051361
   VanWagner LB, 2018, LIVER INT, V38, P706, DOI 10.1111/liv.13603
   VanWagner LB, 2014, ATHEROSCLEROSIS, V235, P599, DOI 10.1016/j.atherosclerosis.2014.05.962
   Virmani R, 2006, J AM COLL CARDIOL, V47, pC13, DOI 10.1016/j.jacc.2005.10.065
   Virtue S, 2010, BBA-MOL CELL BIOL L, V1801, P338, DOI 10.1016/j.bbalip.2009.12.006
   Visseren FLJ, 2021, EUR HEART J, V42, P3227, DOI 10.1093/eurheartj/ehab484
   Wang L, 2018, EXP THER MED, V15, P949, DOI 10.3892/etm.2017.5476
   Wang XH, 2021, HEPAT MON, V21, DOI 10.5812/hepatmon.122772
   Wang ZN, 2014, EUR HEART J, V35, P904, DOI 10.1093/eurheartj/ehu002
   Webber M, 2010, CLIN CHEM LAB MED, V48, P167, DOI 10.1515/CCLM.2010.052
   Wijarnpreecha K, 2021, CLIN MOL HEPATOL, V27, P221, DOI 10.3350/cmh.2020.0239
   Wong VWS, 2016, HEPATOLOGY, V63, P754, DOI 10.1002/hep.28253
   Wong VWS, 2011, GUT, V60, P1721, DOI 10.1136/gut.2011.242016
   Wu RN, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-09851-5
   Xu X, 2015, LIPIDS HEALTH DIS, V14, DOI 10.1186/s12944-015-0141-z
   Yilmaz Y, 2010, ATHEROSCLEROSIS, V211, P182, DOI 10.1016/j.atherosclerosis.2010.01.049
   Yoshitaka H, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000006712
   You SC, 2015, WORLD J GASTROENTERO, V21, P1158, DOI 10.3748/wjg.v21.i4.1158
   Younossi Z, 2018, NAT REV GASTRO HEPAT, V15, P11, DOI 10.1038/nrgastro.2017.109
   Younossi ZM, 2021, JHEP REP, V3, DOI 10.1016/j.jhepr.2021.100305
   Younossi ZM, 2019, J HEPATOL, V71, P793, DOI 10.1016/j.jhep.2019.06.021
   Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431
   Zamparelli MS, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17081225
   Zhang YW, 2019, BMC GENOMICS, V20, DOI 10.1186/s12864-019-6251-7
   Zhou M, 2017, HEPATOL COMMUN, V1, P1024, DOI 10.1002/hep4.1108
   Zou B, 2020, J INTERN MED, V288, P139, DOI 10.1111/joim.13069
NR 172
TC 21
Z9 23
U1 0
U2 26
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD AUG
PY 2022
VL 12
IS 8
AR 1189
DI 10.3390/life12081189
PG 25
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA 4C6EK
UT WOS:000846543900001
PM 36013368
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Paik, SH
   Jang, S
   Joh, HK
   Lim, CS
   Cho, B
   Kwon, O
   Jo, SJ
AF Paik, Seung Hwan
   Jang, Sihyeok
   Joh, Hee-Kyung
   Lim, Chun Soo
   Cho, BeLong
   Kwon, Ohsang
   Jo, Seong Jin
TI Association Between Premature Hair Greying and Metabolic Risk Factors: A
   Cross-sectional Study
SO ACTA DERMATO-VENEREOLOGICA
LA English
DT Article
DE hair greying; premature hair greying; metabolic syndrome; metabolic risk
   factors
ID CORONARY-ARTERY-DISEASE; OXIDATIVE STRESS; PREDICTOR; FOLLICLE; OBESITY;
   MARKER
AB The association of hair greying with metabolic syndrome is not well known, while association with obesity and coronary artery disease has been suggested. A cross-sectional study was conducted to identify an association between premature hair greying and metabolic risk factors. Of the 1,929 young healthy subjects (1,067 men and 862 women), 704 (36.4%) were categorized in the premature hair greying group. Waist circumference (means of non-premature hair greying vs. premature hair greying, 74.3 vs. 76.3 cm; p < 0.001), systolic (109.2 vs. 111.7 mmHg; p < 0.001) and diastolic (65.0 vs. 66.2 mmHg; p = 0.003) blood pressures, and fasting blood sugar (90.8 vs. 91.6 mg/dl; p = 0.013) were higher and serum high-density lipoprotein cholesterol (68.1 vs 65.4 mg/dl; p < 0.001) was lower in premature hair greying group. Multivariate logistic regression analysis showed that metabolic risk factors = 2 was independently associated with premature hair greying after controlling for confounding factors (odds ratio 1.725; p = 0.036). The present study revealed an association between premature hair greying and metabolic risk factors.
C1 [Paik, Seung Hwan; Jang, Sihyeok; Kwon, Ohsang; Jo, Seong Jin] Seoul Natl Univ, Coll Med, Dept Dermatol, 101 Daehangno, Seoul 03080, South Korea.
   [Joh, Hee-Kyung] Seoul Natl Univ, Coll Med, Dept Med, Seoul, South Korea.
   [Cho, BeLong] Seoul Natl Univ, Coll Med, Inst Aging, Seoul, South Korea.
   [Paik, Seung Hwan; Kwon, Ohsang; Jo, Seong Jin] Seoul Natl Univ, Inst Human Environm Interface Biol, Seoul, South Korea.
   [Cho, BeLong] Seoul Natl Univ, Adv Inst Convergence, Seoul, South Korea.
   [Paik, Seung Hwan; Kwon, Ohsang; Jo, Seong Jin] Seoul Natl Univ Hosp, Biomed Res Inst, Lab Cutaneous Aging & Hair Res, Seoul, South Korea.
   [Cho, BeLong] Seoul Natl Univ Hosp, Dept Family Med, Seoul, South Korea.
   [Cho, BeLong] Seoul Natl Univ Hosp, Hlth Promot Ctr, Seoul, South Korea.
   [Paik, Seung Hwan] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Dermatol, Seoul, South Korea.
   [Joh, Hee-Kyung] Seoul Natl Univ, Hlth Serv Ctr, Dept Family Med, Seoul, South Korea.
   [Lim, Chun Soo] Seoul Natl Univ, Boramae Med Ctr, Dept Internal Med, Seoul, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU); Seoul
   National University (SNU); Seoul National University (SNU); Seoul
   National University (SNU); Seoul National University (SNU); Seoul
   National University Hospital; Seoul National University (SNU); Seoul
   National University Hospital; Seoul National University (SNU); Seoul
   National University Hospital; University of Ulsan; Asan Medical Center;
   Seoul National University (SNU); Seoul National University (SNU); Seoul
   National University Hospital
RP Jo, SJ (corresponding author), Seoul Natl Univ, Coll Med, Dept Dermatol, 101 Daehangno, Seoul 03080, South Korea.
EM sj.jo@snu.ac.kr
RI Joh, Hee/J-5674-2012; Cho, Belong/GLU-3443-2022; KWON,
   OHSANG/J-2733-2012
OI Joh, Hee-Kyung/0000-0003-3854-7012; KWON, OHSANG/0000-0003-0464-5124;
   Jo, Seong Jin/0000-0002-2501-7672
CR Adhikari K, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms10815
   Aggarwal A, 2015, ETHIOP J HEALTH SCI, V25, P123, DOI 10.4314/ejhs.v25i2.4
   Al-Hamamy HR, 2012, J FM BAGHDAD, V54, P182
   Arck PC, 2006, FASEB J, V20, P1567, DOI 10.1096/fj.05-4039fje
   Barba C, 2004, LANCET, V363, P157, DOI 10.1016/s0140-6736(03)15268-3
   Bonomini F, 2015, AGING DIS, V6, P109, DOI 10.14336/AD.2014.0305
   Carrier A, 2017, ANTIOXID REDOX SIGN, V26, P429, DOI 10.1089/ars.2016.6929
   Chakrabarty Swagata, 2016, Int J Trichology, V8, P11, DOI 10.4103/0974-7753.179384
   Erdogan T, 2013, INTERNAL MED, V52, P29, DOI 10.2169/internalmedicine.52.7842
   Ford ES, 2002, JAMA-J AM MED ASSOC, V287, P356, DOI 10.1001/jama.287.3.356
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Kadota A, 2007, DIABETES CARE, V30, P1533, DOI 10.2337/dc06-2074
   Kocaman SA, 2012, ANATOL J CARDIOL, V12, P457, DOI 10.5152/akd.2012.150
   Praetorius C, 2013, CELL, V155, P1022, DOI 10.1016/j.cell.2013.10.022
   SCHNOHR P, 1995, AM HEART J, V130, P1003, DOI 10.1016/0002-8703(95)90201-5
   Shin H, 2015, J AM ACAD DERMATOL, V72, P321, DOI 10.1016/j.jaad.2014.11.008
   Spahis S, 2017, ANTIOXID REDOX SIGN, V26, P445, DOI 10.1089/ars.2016.6756
   Tobin DJ, 2001, EXP GERONTOL, V36, P29, DOI 10.1016/S0531-5565(00)00210-2
   Trueb Ralph M, 2005, J Cosmet Dermatol, V4, P60, DOI 10.1111/j.1473-2165.2005.40203.x
NR 20
TC 7
Z9 8
U1 2
U2 20
PU ACTA DERMATO-VENEREOLOGICA
PI UPPSALA
PA TRADGARDSGATAN 14, UPPSALA, SE-753 09, SWEDEN
SN 0001-5555
EI 1651-2057
J9 ACTA DERM-VENEREOL
JI Acta Derm.-Venereol.
PD SEP
PY 2018
VL 98
IS 8
BP 748
EP 752
DI 10.2340/00015555-2974
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA GR3RF
UT WOS:000442511400005
PM 29799603
OA gold
DA 2025-06-11
ER

PT J
AU Lee, S
   Kim, DH
   Nam, HY
   Roh, YK
   Ju, SY
   Yoon, YJ
   Nam, GE
   Choi, JS
   Lee, JE
   Sang, JE
   Han, K
   Park, YG
AF Lee, Sangsu
   Kim, Do Hoon
   Nam, Hyo Yun
   Roh, Yong-Kyun
   Ju, Sang-Yhun
   Yoon, Yeo-Joon
   Nam, Ga-Eun
   Choi, Jun-Seok
   Lee, Jong-Eun
   Sang, Jung-Eun
   Han, Kyungdo
   Park, Yong-Gyu
TI Serum Gamma-Glutamyltransferase Levels are Associated With Concomitant
   Cardiovascular Risk Factors in Korean Hypertensive Patients A
   Nationwide Population-Based Study
SO MEDICINE
LA English
DT Article
ID YOUNG-ADULTS CARDIA; NORMAL BLOOD-PRESSURE; OXIDATIVE STRESS; METABOLIC
   SYNDROME; COHORT; GLUTAMYLTRANSFERASE; MICROALBUMINURIA;
   PREHYPERTENSION; TRANSPEPTIDASE; METAANALYSIS
AB Previous studies suggested that serum gamma-glutamyltransferase (GGT) levels were associated with the prevalence of cardiovascular disease (CVD) risk factors including hypertension, diabetes mellitus (DM), and metabolic syndrome (MetS) in the general population. We aimed to investigate the relationship between serum GGT levels and CVD risk factors in Korean hypertensive patients.
   This cross-sectional study was based on data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2011 to 2012. The analysis included 1541 hypertensive participants. Study participants were divided into groups according to tertiles of serum GGT with cutoff points of 20 and 35 U/L.
   Serum GGT levels were positively associated with the components of MetS (P value < 0.05, except for systolic blood pressure and high-density lipoprotein cholesterol). After adjusting for possible confounders, serumGGT levels were associated with an increased risk of MetS, high waist circumference, high triglyceride level, fasting plasma glucose, DM, and the urinary albumin-to-creatinine ratio (P = 0.001).
   In hypertensive patients, serum GGT levels are positively associated with major cardiovascular risk factors such as MetS, DM, and urinary albumin excretion.
C1 [Lee, Sangsu; Kim, Do Hoon; Nam, Hyo Yun; Yoon, Yeo-Joon; Nam, Ga-Eun; Choi, Jun-Seok; Lee, Jong-Eun; Sang, Jung-Eun] Korea Univ, Coll Med, Dept Family Med, Seoul, South Korea.
   [Roh, Yong-Kyun] Hallym Univ, Coll Med, Dept Family Med, Chunchon, South Korea.
   [Ju, Sang-Yhun] Catholic Univ, Dept Biostat, Seoul, South Korea.
   [Han, Kyungdo; Park, Yong-Gyu] Catholic Univ, Coll Med, Dept Biostat, Seoul, South Korea.
   [Nam, Ga-Eun] Korea Univ, Dept Family Med, Ansan Hosp, Coll Med, 516 Gojan1-Dong, Ansan, Gyeonggi Do, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine); Hallym
   University; Catholic University of Korea; Catholic University of Korea;
   Korea University; Korea University Medicine (KU Medicine)
RP Kim, DH (corresponding author), Korea Univ, Dept Family Med, Ansan Hosp, Coll Med, 516 Gojan1-Dong, Ansan, Gyeonggi Do, South Korea.
EM kmcfm@hanmail.net; yhn231@hanmail.net
RI Nam, Ga Eun/AAU-6055-2020; Lee, Jung-Seok/L-6826-2019; Ju,
   Sang/Q-2946-2019
OI Nam, Ga Eun/0000-0002-6739-9904; Ju, Sang Yhun/0000-0002-0553-7128;
   Park, Yong Gyu/0000-0002-8721-3230; Kim, Do Hoon/0000-0001-7421-4501
CR Agarwal DP, 2002, ALCOHOL ALCOHOLISM, V37, P409, DOI 10.1093/alcalc/37.5.409
   Bo S, 2005, WORLD J GASTROENTERO, V11, P7109, DOI 10.3748/wjg.v11.i45.7109
   Bradley R, 2013, BIOMARK MED, V7, P709, DOI 10.2217/bmm.13.71
   Chun MY, 2012, KOREAN J FAM MED, V33, P144, DOI 10.4082/kjfm.2012.33.3.144
   Emdin M, 2005, CIRCULATION, V112, P2078, DOI 10.1161/CIRCULATIONAHA.105.571919
   Franzini M, 2010, CLIN CHEM LAB MED, V48, P713, DOI 10.1515/CCLM.2010.125
   Franzini M, 2009, ATHEROSCLEROSIS, V202, P119, DOI 10.1016/j.atherosclerosis.2008.03.023
   Fraser A, 2009, DIABETES CARE, V32, P741, DOI 10.2337/dc08-1870
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Ha KH, 2014, J KOREAN MED SCI, V29, P1379, DOI 10.3346/jkms.2014.29.10.1379
   Kim NH, 2012, CLIN EXP HYPERTENS, V34, P402, DOI 10.3109/10641963.2012.665539
   Kim YS, 2013, HYPERTENS RES, V36, P807, DOI 10.1038/hr.2013.44
   Kotani K, 2008, CLIN CHIM ACTA, V389, P189, DOI 10.1016/j.cca.2007.11.026
   KUGELMAN A, 1994, AM J RESP CELL MOL, V11, P586, DOI 10.1165/ajrcmb.11.5.7946387
   Kunutsor SK, 2015, INT J CLIN PRACT, V69, P136, DOI 10.1111/ijcp.12507
   Lee DH, 2005, CLIN CHEM, V51, P1185, DOI 10.1373/clinchem.2004.045872
   Lee DH, 2004, FREE RADICAL RES, V38, P535, DOI 10.1080/10715760410001694026
   Lee DH, 2004, AM J CLIN NUTR, V79, P600
   Lee DH, 2003, CLIN CHEM, V49, P1358, DOI 10.1373/49.8.1358
   Lee DH, 2003, DIABETOLOGIA, V46, P359, DOI 10.1007/s00125-003-1036-5
   Levey AS, 2003, ANN INTERN MED, V139, P137, DOI 10.7326/0003-4819-139-2-200307150-00013
   Liu CF, 2012, INT J CLIN PRACT, V66, P692, DOI 10.1111/j.1742-1241.2012.02959.x
   Ryoo JH, 2014, DIABETIC MED, V31, P455, DOI 10.1111/dme.12315
   Shankar A, 2007, CIRC J, V71, P1567, DOI 10.1253/circj.71.1567
   Vasan Ramachandran S., 2001, New England Journal of Medicine, V345, P1291, DOI 10.1056/NEJMoa003417
   YAMADA Y, 1991, HYPERTENSION, V18, P819, DOI 10.1161/01.HYP.18.6.819
NR 26
TC 1
Z9 3
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD DEC
PY 2015
VL 94
IS 50
AR e2171
DI 10.1097/MD.0000000000002171
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DD3XE
UT WOS:000369855900022
PM 26683926
OA Green Published, gold
DA 2025-06-11
ER

PT B
AU Cai, DS
   Liu, TW
AF Cai, Dongsheng
   Liu, Tiewen
GP Annals NY Acad Sci
TI Hypothalamic inflammation: a double-edged sword to nutritional diseases
SO YEAR IN DIABETES AND OBESITY
SE Annals of the New York Academy of Sciences-Series
LA English
DT Article; Book Chapter
DE hypothalamus; brain; inflammation; energy balance; metabolism; disease
ID NF-KAPPA-B; ENDOPLASMIC-RETICULUM STRESS; ACTIVATED PROTEIN-KINASE;
   DIET-INDUCED OBESITY; HEPATIC INSULIN-RESISTANCE; HIGH-FAT DIET;
   PATTERN-RECOGNITION RECEPTORS; IMPROVES GLUCOSE-HOMEOSTASIS; ENHANCED
   LEPTIN SENSITIVITY; MECHANISMS LINKING OBESITY
AB The hypothalamus is one of the master regulators of various physiological processes, including energy balance and nutrient metabolism. These regulatory functions are mediated by discrete hypothalamic regions that integrate metabolic sensing with neuroendocrine and neural controls of systemic physiology. Neurons and nonneuronal cells in these hypothalamic regions act supportively to execute metabolic regulations. Under conditions of brain and hypothalamic inflammation, which may result from overnutrition-induced intracellular stresses or disease-associated systemic inflammatory factors, extracellular and intracellular environments of hypothalamic cells are disrupted, leading to central metabolic dysregulations and various diseases. Recent research has begun to elucidate the effects of hypothalamic inflammation in causing diverse components of metabolic syndrome leading to diabetes and cardiovascular disease. These new understandings have provocatively expanded previous knowledge on the cachectic roles of brain inflammatory response in diseases, such as infections and cancers. This review describes the molecular and cellular characteristics of hypothalamic inflammation in metabolic syndrome and related diseases as opposed to cachectic diseases, and also discusses concepts and potential applications of inhibiting central/hypothalamic inflammation to treat nutritional diseases.
C1 [Cai, Dongsheng; Liu, Tiewen] Albert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, Bronx, NY 10461 USA.
C3 Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva
   University
RP Cai, DS (corresponding author), Albert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, 1300 Morris Pk Ave, Bronx, NY 10461 USA.
EM dongsheng.cai@einstein.yu.edu
RI Cai, Dongsheng/CAH-8271-2022
CR Abelson P, 2004, SCIENCE, V304, P1413, DOI 10.1126/science.304.5676.1413
   Ahima RS, 2008, MOL ENDOCRINOL, V22, P1023, DOI 10.1210/me.2007-0529
   Ahima RS, 2006, DIABETES, V55, pS145, DOI 10.2337/db06-S018
   Aikin R, 2004, ENDOCRINOLOGY, V145, P4522, DOI 10.1210/en.2004-0488
   Allen RT, 2005, APOPTOSIS, V10, P525, DOI 10.1007/s10495-005-1882-3
   Andersson U, 2004, J BIOL CHEM, V279, P12005, DOI 10.1074/jbc.C300557200
   [Anonymous], OB OV
   Anseloni VCZ, 2008, J PAIN, V9, P732, DOI 10.1016/j.jpain.2008.03.004
   Arruda AP, 2011, ENDOCRINOLOGY, V152, P1314, DOI 10.1210/en.2010-0659
   Ashitani J, 2009, PEPTIDES, V30, P1951, DOI 10.1016/j.peptides.2009.07.002
   Asilmaz E, 2004, J CLIN INVEST, V113, P414, DOI 10.1172/JCI200419511
   Autret A, 2008, J VIROL, V82, P3796, DOI 10.1128/JVI.02020-07
   Baeuerle PA, 1996, CELL, V87, P13, DOI 10.1016/S0092-8674(00)81318-5
   Balaban RS, 2005, CELL, V120, P483, DOI 10.1016/j.cell.2005.02.001
   Balthasar N, 2005, CELL, V123, P493, DOI 10.1016/j.cell.2005.08.035
   Balthasar N, 2004, NEURON, V42, P983, DOI 10.1016/j.neuron.2004.06.004
   Bamba V, 2007, GASTROENTEROLOGY, V132, P2181, DOI 10.1053/j.gastro.2007.03.056
   Banno R, 2010, J CLIN INVEST, V120, P720, DOI 10.1172/JCI39620
   Barger JL, 2003, EXP GERONTOL, V38, P1343, DOI 10.1016/j.exger.2003.10.017
   Bartfai T, 2001, NATURE, V410, P425, DOI 10.1038/35068663
   Bartolomucci A, 2006, P NATL ACAD SCI USA, V103, P14584, DOI 10.1073/pnas.0606102103
   Barton GM, 2003, SCIENCE, V300, P1524, DOI 10.1126/science.1085536
   Bates SH, 2003, NATURE, V421, P856, DOI 10.1038/nature01388
   Belgardt BF, 2010, ANN NY ACAD SCI, V1212, P97, DOI 10.1111/j.1749-6632.2010.05799.x
   Belgardt BF, 2010, P NATL ACAD SCI USA, V107, P6028, DOI 10.1073/pnas.1001796107
   Bence KK, 2006, NAT MED, V12, P917, DOI 10.1038/nm1435
   Benicky J, 2011, NEUROPSYCHOPHARMACOL, V36, P857, DOI 10.1038/npp.2010.225
   Beretta E, 2002, PEPTIDES, V23, P975, DOI 10.1016/S0196-9781(02)00021-9
   Berg AH, 2005, CIRC RES, V96, P939, DOI 10.1161/01.RES.0000163635.62927.34
   Bernal-Mizrachi C, 2005, NATURE, V435, P502, DOI 10.1038/nature03527
   Beutler B, 2004, NATURE, V430, P257, DOI 10.1038/nature02761
   Bishop NA, 2010, NATURE, V464, P529, DOI 10.1038/nature08983
   Boaz M, 2009, DIABETIC MED, V26, P708, DOI 10.1111/j.1464-5491.2009.02747.x
   Bogoyevitch MA, 2006, BIOESSAYS, V28, P923, DOI 10.1002/bies.20458
   Bonnard C, 2008, J CLIN INVEST, V118, P789, DOI 10.1172/JCI32601
   Bossy-Wetzel E, 2004, NEURON, V41, P351, DOI 10.1016/S0896-6273(04)00015-7
   Bourdeau A, 2005, CURR OPIN CELL BIOL, V17, P203, DOI 10.1016/j.ceb.2005.02.001
   Bruckner SR, 2001, J NEUROCHEM, V78, P298, DOI 10.1046/j.1471-4159.2001.00400.x
   Bruckner SR, 2002, J NEUROSCI RES, V70, P665, DOI 10.1002/jnr.10437
   Brüning JC, 2000, SCIENCE, V289, P2122, DOI 10.1126/science.289.5487.2122
   Buczkowska Ewa Otto, 2002, Wiad Lek, V55, P731
   Burks DJ, 2000, NATURE, V407, P377, DOI 10.1038/35030105
   Burnett C, 2011, NATURE, V477, P482, DOI 10.1038/nature10296
   Butler AA, 2010, DIABETES, V59, P323, DOI 10.2337/db09-1471
   Butler D, 2006, ANTIOXID REDOX SIGN, V8, P185, DOI 10.1089/ars.2006.8.185
   Byerly MS, 2009, AM J PHYSIOL-REG I, V296, pR1180, DOI 10.1152/ajpregu.90813.2008
   Byon JCH, 1998, MOL CELL BIOCHEM, V182, P101, DOI 10.1023/A:1006868409841
   Cai DS, 2009, CELL CYCLE, V8, P2542, DOI 10.4161/cc.8.16.9386
   Çakir I, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0008322
   Caricilli AM, 2008, J ENDOCRINOL, V199, P399, DOI 10.1677/JOE-08-0354
   Castrogiovanni D, 2008, NEUROENDOCRINOLOGY, V88, P227, DOI 10.1159/000124131
   Catania C, 2011, INT J OBESITY, V35, P751, DOI 10.1038/ijo.2010.208
   Chakravarthy MV, 2009, J LIPID RES, V50, P630, DOI 10.1194/jlr.M800379-JLR200
   Challis BG, 2004, P NATL ACAD SCI USA, V101, P4695, DOI 10.1073/pnas.0306931101
   Chan O, 2006, DIABETES, V55, P1080, DOI 10.2337/diabetes.55.04.06.db05-0958
   Chan O, 2011, DIABETES, V60, P1582, DOI 10.2337/db10-1579
   Chang LF, 2001, NATURE, V410, P37, DOI 10.1038/35065000
   Chapuis N, 2010, BLOOD, V116, P4240, DOI 10.1182/blood-2009-12-260711
   Chen AS, 2000, NAT GENET, V26, P97, DOI 10.1038/79254
   Chen C, 2010, J CLIN INVEST, V120, P4091, DOI 10.1172/JCI43873
   Cheyuo C, 2011, J CEREBR BLOOD F MET, V31, P1187, DOI 10.1038/jcbfm.2011.24
   Chida D, 2008, DIABETOLOGIA, V51, P1698, DOI 10.1007/s00125-008-1075-z
   Chida D, 2006, DIABETES, V55, P971, DOI 10.2337/diabetes.55.04.06.db05-1250
   Choi SJ, 2010, AM J PHYSIOL-ENDOC M, V298, pE1122, DOI 10.1152/ajpendo.00006.2010
   Choudhury AI, 2005, J CLIN INVEST, V115, P940
   Claret M, 2007, J CLIN INVEST, V117, P2325, DOI 10.1172/JCI31516
   Claret M, 2011, DIABETES, V60, P735, DOI 10.2337/db10-1055
   Cohen P, 2001, J CLIN INVEST, V108, P1113, DOI 10.1172/JCI13914
   Coll AP, 2007, CELL, V129, P251, DOI 10.1016/j.cell.2007.04.001
   Colton CA, 2009, J NEUROIMMUNE PHARM, V4, P399, DOI 10.1007/s11481-009-9164-4
   Cone RD, 2005, NAT NEUROSCI, V8, P571, DOI 10.1038/nn1455
   Coppari R, 2005, CELL METAB, V1, P63, DOI 10.1016/j.cmet.2004.12.004
   Cota D, 2006, SCIENCE, V312, P927, DOI 10.1126/science.1124147
   Cota D, 2003, J CLIN INVEST, V112, P423, DOI 10.1172/JCI17725
   COYLE JT, 1993, SCIENCE, V262, P689, DOI 10.1126/science.7901908
   Cui LB, 2006, CELL, V127, P59, DOI 10.1016/j.cell.2006.09.015
   Cullinan SB, 2006, INT J BIOCHEM CELL B, V38, P317, DOI 10.1016/j.biocel.2005.09.018
   Dantzer R, 2001, ANN NY ACAD SCI, V933, P222
   De Souza CT, 2005, ENDOCRINOLOGY, V146, P4192, DOI 10.1210/en.2004-1520
   Deans C, 2005, CURR OPIN CLIN NUTR, V8, P265, DOI 10.1097/01.mco.0000165004.93707.88
   DeBoer MD, 2008, NUTRITION, V24, P806, DOI 10.1016/j.nut.2008.06.013
   Delibegovic M, 2007, MOL CELL BIOL, V27, P7727, DOI 10.1128/MCB.00959-07
   Denis RG, 2010, NEUROSCIENCE, V170, P1035, DOI 10.1016/j.neuroscience.2010.08.013
   Després JP, 2006, NATURE, V444, P881, DOI 10.1038/nature05488
   Dhillon H, 2006, NEURON, V49, P191, DOI 10.1016/j.neuron.2005.12.021
   Dietrich MO, 2010, J NEUROSCI, V30, P11815, DOI 10.1523/JNEUROSCI.2234-10.2010
   DiMauro S, 2008, ANNU REV NEUROSCI, V31, P91, DOI 10.1146/annurev.neuro.30.051606.094302
   Dominguez H, 2005, J VASC RES, V42, P517, DOI 10.1159/000088261
   Donmez G, 2010, AGING CELL, V9, P285, DOI 10.1111/j.1474-9726.2010.00548.x
   Drucker DJ, 2007, J CLIN INVEST, V117, P24, DOI 10.1172/JCI30076
   Duan SZ, 2009, CURR OPIN NEPHROL HY, V18, P128, DOI 10.1097/MNH.0b013e328325803b
   Dubé N, 2005, BBA-PROTEINS PROTEOM, V1754, P108, DOI 10.1016/j.bbapap.2005.07.030
   Duffy D, 2007, TRENDS CARDIOVAS MED, V17, P35, DOI 10.1016/j.tcm.2006.11.003
   Duvnjak L, 2009, J PHYSIOL PHARMACOL, V60, P19
   Ebato C, 2008, CELL METAB, V8, P325, DOI 10.1016/j.cmet.2008.08.009
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Ek M, 2001, NATURE, V410, P430, DOI 10.1038/35068632
   Elchebly M, 1999, SCIENCE, V283, P1544, DOI 10.1126/science.283.5407.1544
   Elenkov IJ, 2005, NEUROIMMUNOMODULAT, V12, P255, DOI 10.1159/000087104
   Elmquist JK, 2005, J COMP NEUROL, V493, P63, DOI 10.1002/cne.20786
   Elward K, 2003, MOL IMMUNOL, V40, P85, DOI 10.1016/S0161-5890(03)00109-3
   Endo M, 2007, REGUL PEPTIDES, V140, P94, DOI 10.1016/j.regpep.2006.11.022
   Enjyoji K, 2008, DIABETES, V57, P2311, DOI 10.2337/db07-1265
   Farooqui T, 2011, PARKINSONS DIS-US, V2011, DOI 10.4061/2011/247467
   Ferrante AW, 2007, J INTERN MED, V262, P408, DOI 10.1111/j.1365-2796.2007.01852.x
   Fessler MB, 2009, CURR OPIN LIPIDOL, V20, P379, DOI 10.1097/MOL.0b013e32832fa5c4
   Finck BN, 1997, BRAIN RES, V761, P333, DOI 10.1016/S0006-8993(97)00451-4
   Fleischman A, 2007, AM J PHYSIOL-ENDOC M, V292, pE1666, DOI 10.1152/ajpendo.00550.2006
   Flier JS, 2006, SCIENCE, V312, P861, DOI 10.1126/science.1127971
   Friedman JM, 2009, NATURE, V459, P340, DOI 10.1038/459340a
   Friedman JM, 2004, NAT MED, V10, P563, DOI 10.1038/nm0604-563
   Frisard MI, 2010, AM J PHYSIOL-ENDOC M, V298, pE988, DOI 10.1152/ajpendo.00307.2009
   Fujitani Y, 2009, AUTOPHAGY, V5, P280, DOI 10.4161/auto.5.2.7656
   Gaddam KK, 2011, CURR HYPERTENS REP, V13, P142, DOI 10.1007/s11906-011-0179-x
   Gangloff YG, 2004, MOL CELL BIOL, V24, P9508, DOI 10.1128/MCB.24.21.9508-9516.2004
   Gao ZG, 2009, J BIOL CHEM, V284, P18368, DOI 10.1074/jbc.M109.007260
   Garcia MC, 2006, DIABETES, V55, P1205, DOI 10.2337/db05-1304
   Garden GA, 2006, J NEUROIMMUNE PHARM, V1, P127, DOI 10.1007/s11481-006-9015-5
   Godbout JP, 2004, J NEUROIMMUNOL, V147, P141, DOI 10.1016/j.jneuroim.2003.10.031
   Golden TR, 2002, AGING CELL, V1, P117, DOI 10.1046/j.1474-9728.2002.00015.x
   Golden TR, 2001, MECH AGEING DEV, V122, P1577, DOI 10.1016/S0047-6374(01)00288-3
   Goldfine AB, 2010, ANN INTERN MED, V152, P346, DOI 10.7326/0003-4819-152-6-201003160-00004
   Goldfine AB, 2008, CTS-CLIN TRANSL SCI, V1, P36, DOI 10.1111/j.1752-8062.2008.00026.x
   Goldstein BJ, 1998, MOL CELL BIOCHEM, V182, P91, DOI 10.1023/A:1006812218502
   Gorina R, 2011, GLIA, V59, P242, DOI 10.1002/glia.21094
   Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
   Grossberg AJ, 2010, PHYSIOL BEHAV, V100, P478, DOI 10.1016/j.physbeh.2010.03.011
   Grossberg AJ, 2010, ENDOCRINOLOGY, V151, P606, DOI 10.1210/en.2009-1135
   GRUNFELD C, 1992, NEW ENGL J MED, V327, P329, DOI 10.1056/NEJM199207303270506
   Guarente L, 2006, NATURE, V444, P868, DOI 10.1038/nature05486
   Guarente L, 2011, NEW ENGL J MED, V364, P2235, DOI 10.1056/NEJMra1100831
   Haigis MC, 2010, ANNU REV PATHOL-MECH, V5, P253, DOI 10.1146/annurev.pathol.4.110807.092250
   Hanada R, 2004, NAT MED, V10, P1067, DOI 10.1038/nm1106
   Hara T, 2006, NATURE, V441, P885, DOI 10.1038/nature04724
   Harrison David G, 2008, Curr Cardiol Rep, V10, P464
   Hauwel M, 2005, BRAIN RES REV, V48, P220, DOI 10.1016/j.brainresrev.2004.12.012
   Heisler LK, 2006, NEURON, V51, P239, DOI 10.1016/j.neuron.2006.06.004
   Herman MA, 2006, J CLIN INVEST, V116, P1767, DOI 10.1172/JCI29027
   Hill JW, 2010, CELL METAB, V11, P286, DOI 10.1016/j.cmet.2010.03.002
   Himes RW, 2010, FASEB J, V24, P731, DOI 10.1096/fj.09-141929
   Hirosumi J, 2002, NATURE, V420, P333, DOI 10.1038/nature01137
   Hirschey MD, 2011, MOL CELL, V44, P177, DOI 10.1016/j.molcel.2011.07.019
   Hoekstra JG, 2011, ALZHEIMERS RES THER, V3, DOI 10.1186/alzrt83
   Hollis JH, 2010, NEUROPHARMACOLOGY, V58, P730, DOI 10.1016/j.neuropharm.2009.12.016
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   Howard JK, 2006, TRENDS ENDOCRIN MET, V17, P365, DOI 10.1016/j.tem.2006.09.007
   Howard JK, 2004, NAT MED, V10, P734, DOI 10.1038/nm1072
   Humphreys MH, 2007, CURR OPIN NEPHROL HY, V16, P32, DOI 10.1097/MNH.0b013e3280117fb5
   Humphreys MH, 2011, NAT MED, V17, P782, DOI 10.1038/nm0711-782
   Hundal RS, 2002, J CLIN INVEST, V109, P1321, DOI 10.1172/JCI200214955
   Hunot S, 2004, P NATL ACAD SCI USA, V101, P665, DOI 10.1073/pnas.0307453101
   Huszar D, 1997, CELL, V88, P131, DOI 10.1016/S0092-8674(00)81865-6
   Inhoff T, 2010, PEPTIDES, V31, P257, DOI 10.1016/j.peptides.2009.11.024
   Inui A, 2002, CA-CANCER J CLIN, V52, P72, DOI 10.3322/canjclin.52.2.72
   Inui A, 2001, TRENDS IMMUNOL, V22, P469, DOI 10.1016/S1471-4906(01)01981-0
   Ishii M, 2003, P NATL ACAD SCI USA, V100, P10540, DOI 10.1073/pnas.1334189100
   Jang PG, 2010, J BIOL CHEM, V285, P9706, DOI 10.1074/jbc.M109.070706
   Jiang SN, 2011, AM J PHYSIOL-GASTR L, V301, pG454, DOI 10.1152/ajpgi.00148.2011
   Jin SK, 2008, AUTOPHAGY, V4, P563, DOI 10.4161/auto.5830
   Kahn BB, 2005, CELL METAB, V1, P15, DOI 10.1016/j.cmet.2004.12.003
   Kahn BB, 2000, J CLIN INVEST, V106, P473, DOI 10.1172/JCI10842
   Kahn SE, 2006, NATURE, V444, P840, DOI 10.1038/nature05482
   Kaneto H, 2004, NAT MED, V10, P1128, DOI 10.1038/nm1111
   Kang YM, 2009, CARDIOVASC RES, V82, P503, DOI 10.1093/cvr/cvp073
   Karagiannides I, 2008, GASTROENTEROLOGY, V134, P747, DOI 10.1053/j.gastro.2007.12.032
   Karczewska-Kupczewska M, 2011, CLIN BIOCHEM, V44, P817, DOI 10.1016/j.clinbiochem.2011.05.008
   Kars M, 2010, DIABETES, V59, P1899, DOI 10.2337/db10-0308
   Kawai T, 2007, TRENDS MOL MED, V13, P460, DOI 10.1016/j.molmed.2007.09.002
   Kelly DP, 2011, NATURE, V470, P342, DOI 10.1038/nature09896
   Kernie SG, 2000, EMBO J, V19, P1290, DOI 10.1093/emboj/19.6.1290
   Khamzina L, 2005, ENDOCRINOLOGY, V146, P1473, DOI 10.1210/en.2004-0921
   Kievit P, 2006, CELL METAB, V4, P123, DOI 10.1016/j.cmet.2006.06.010
   Kim I, 2008, NAT REV DRUG DISCOV, V7, P1013, DOI 10.1038/nrd2755
   Kim JS, 2008, HEPATOLOGY, V47, P1725, DOI 10.1002/hep.22187
   Kim MS, 2004, NAT MED, V10, P727, DOI 10.1038/nm1061
   Klaman LD, 2000, MOL CELL BIOL, V20, P5479, DOI 10.1128/MCB.20.15.5479-5489.2000
   Kleinridders A, 2009, CELL METAB, V10, P249, DOI 10.1016/j.cmet.2009.08.013
   Klöckener T, 2011, NAT NEUROSCI, V14, P911, DOI 10.1038/nn.2847
   Knight CM, 2011, DIABETES, V60, P2691, DOI 10.2337/db10-0987
   Könner AC, 2007, CELL METAB, V5, P438, DOI 10.1016/j.cmet.2007.05.004
   Könner AC, 2011, TRENDS ENDOCRIN MET, V22, P16, DOI 10.1016/j.tem.2010.08.007
   Kokoeva MV, 2005, SCIENCE, V310, P679, DOI 10.1126/science.1115360
   Komatsu M, 2005, J CELL BIOL, V169, P425, DOI 10.1083/jcb.200412022
   Komatsu M, 2006, NATURE, V441, P880, DOI 10.1038/nature04723
   Korhonen P, 1997, NEUROSCI LETT, V225, P61, DOI 10.1016/S0304-3940(97)00190-0
   Kriete A, 2009, EXP GERONTOL, V44, P250, DOI 10.1016/j.exger.2008.12.005
   Kuan CY, 2003, P NATL ACAD SCI USA, V100, P15184, DOI 10.1073/pnas.2336254100
   Kyriakis JM, 1996, J BIOL CHEM, V271, P24313, DOI 10.1074/jbc.271.40.24313
   Kyrou I, 2009, CURR OPIN PHARMACOL, V9, P787, DOI 10.1016/j.coph.2009.08.007
   Lai V, 2008, HEAD NECK-J SCI SPEC, V30, P67, DOI 10.1002/hed.20662
   Lam NT, 2004, MOL ENDOCRINOL, V18, P1333, DOI 10.1210/me.2002-0193
   Lam TKT, 2005, NAT NEUROSCI, V8, P579, DOI 10.1038/nn1456
   Lam TKT, 2005, NAT MED, V11, P320, DOI 10.1038/nm1201
   LANDSBERG L, 1978, NEW ENGL J MED, V298, P1295, DOI 10.1056/NEJM197806082982306
   Larsen CM, 2007, NEW ENGL J MED, V356, P1517, DOI 10.1056/NEJMoa065213
   Lawrence CB, 2001, J NEUROENDOCRINOL, V13, P490, DOI 10.1046/j.1365-2826.2001.00660.x
   Lazartigues E, 2002, CIRC RES, V90, P617, DOI 10.1161/01.RES.0000012460.85923.F0
   Lee DF, 2007, CELL, V130, P440, DOI 10.1016/j.cell.2007.05.058
   Lee GH, 1996, NATURE, V379, P632, DOI 10.1038/379632a0
   Lehrke M, 2004, NAT MED, V10, P126, DOI 10.1038/nm0204-126
   Levine B, 2008, CELL, V132, P27, DOI 10.1016/j.cell.2007.12.018
   Li H, 2008, J MOL MED, V86, P1113, DOI 10.1007/s00109-008-0373-8
   Li XM, 2011, J HEMATOL ONCOL, V4, DOI 10.1186/1756-8722-4-8
   Lichtenstein AH, 2006, CIRCULATION, V114, P82, DOI 10.1161/CIRCULATIONAHA.106.176158
   Lin JD, 2004, CELL, V119, P121, DOI 10.1016/j.cell.2004.09.013
   Lin MT, 2006, NATURE, V443, P787, DOI 10.1038/nature05292
   Liu QA, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1000575
   Loh K, 2011, CELL METAB, V14, P684, DOI 10.1016/j.cmet.2011.09.011
   Long YC, 2006, J CLIN INVEST, V116, P1776, DOI 10.1172/JCI29044
   Lowell BB, 2005, SCIENCE, V307, P384, DOI 10.1126/science.1104343
   Lumeng CN, 2011, J CLIN INVEST, V121, P2111, DOI 10.1172/JCI57132
   MacDonald Neil, 2007, J Support Oncol, V5, P157
   Mantovani Giovanni, 2008, Curr Opin Support Palliat Care, V2, P275, DOI 10.1097/SPC.0b013e32830f47e4
   Mantovani G, 2010, J MOL MED-JMM, V88, P85, DOI 10.1007/s00109-009-0547-z
   Mantzoros C S, 1995, Adv Endocrinol Metab, V6, P193
   Marcora SM, 2006, AM J CLIN NUTR, V84, P1463, DOI 10.1093/ajcn/84.6.1463
   Marsh DJ, 2002, P NATL ACAD SCI USA, V99, P3240, DOI 10.1073/pnas.052706899
   Martin TL, 2006, J BIOL CHEM, V281, P18933, DOI 10.1074/jbc.M512831200
   Martinez-Vicente M, 2005, EXP GERONTOL, V40, P622, DOI 10.1016/j.exger.2005.07.005
   Mashaly Hazem Antar, 2008, Cleve Clin J Med, V75 Suppl 2, pS26
   Masiero E, 2009, CELL METAB, V10, P507, DOI 10.1016/j.cmet.2009.10.008
   Matsuki T, 2003, J EXP MED, V198, P877, DOI 10.1084/jem.20030299
   Mattson MP, 2006, NAT REV NEUROSCI, V7, P278, DOI 10.1038/nrn1886
   Matus S, 2008, CURR MOL MED, V8, P157, DOI 10.2174/156652408784221324
   McClung JM, 2010, AM J PHYSIOL-CELL PH, V298, pC542, DOI 10.1152/ajpcell.00192.2009
   McLaughlin M, 2011, BRIT J PHARMACOL, V162, P328, DOI 10.1111/j.1476-5381.2010.01064.x
   McMackin Craig J, 2007, J Clin Hypertens (Greenwich), V9, P249
   McNally L, 2008, CNS SPECTRUMS, V13, P501, DOI 10.1017/S1092852900016734
   Meister B, 2007, PHYSIOL BEHAV, V92, P263, DOI 10.1016/j.physbeh.2007.05.021
   Melov S, 2004, TRENDS NEUROSCI, V27, P601, DOI 10.1016/j.tins.2004.08.004
   Melov S, 2000, ANN NY ACAD SCI, V908, P219
   Meng QY, 2011, J BIOL CHEM, V286, P32324, DOI 10.1074/jbc.M111.254417
   Meylan E, 2006, NATURE, V442, P39, DOI 10.1038/nature04946
   Milanski M, 2009, J NEUROSCI, V29, P359, DOI 10.1523/JNEUROSCI.2760-08.2009
   Miller EJ, 2008, NATURE, V451, P578, DOI 10.1038/nature06504
   Milne JC, 2008, CURR OPIN CHEM BIOL, V12, P11, DOI 10.1016/j.cbpa.2008.01.019
   Minokoshi Y, 2004, NATURE, V428, P569, DOI 10.1038/nature02440
   Moraes JC, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005045
   Mori H, 2004, NAT MED, V10, P739, DOI 10.1038/nm1071
   Mori H, 2009, CELL METAB, V9, P362, DOI 10.1016/j.cmet.2009.03.005
   Morimoto S, 2002, NEUROPEPTIDES, V36, P194, DOI 10.1054/npep.2002.0894
   Morinaga H, 2008, J VET MED SCI, V70, P1239, DOI 10.1292/jvms.70.1239
   Morris DL, 2009, AM J PHYSIOL-ENDOC M, V297, pE1247, DOI 10.1152/ajpendo.00274.2009
   Morton GJ, 2006, NATURE, V443, P289, DOI 10.1038/nature05026
   Morton GJ, 2003, ENDOCRINOLOGY, V144, P2016, DOI 10.1210/en.2002-0115
   Morton GJ, 2007, J PHYSIOL-LONDON, V583, P437, DOI 10.1113/jphysiol.2007.135590
   Moulana M, 2011, CURR HYPERTENS REP, V13, P158, DOI 10.1007/s11906-011-0184-0
   Münzberg H, 2004, ENDOCRINOLOGY, V145, P4880, DOI 10.1210/en.2004-0726
   Murphy KT, 2009, EXPERT OPIN EMERG DR, V14, P619, DOI 10.1517/14728210903369351
   Murphy KG, 2006, NATURE, V444, P854, DOI 10.1038/nature05484
   Murumkar PR, 2010, EXPERT OPIN THER PAT, V20, P31, DOI 10.1517/13543770903465157
   Muse ED, 2007, J CLIN INVEST, V117, P1670, DOI 10.1172/JCI30440
   Myers MG, 2008, ANNU REV PHYSIOL, V70, P537, DOI 10.1146/annurev.physiol.70.113006.100707
   Nguyen MTA, 2007, J BIOL CHEM, V282, P35279, DOI 10.1074/jbc.M706762200
   Nguyen MD, 2002, NAT REV NEUROSCI, V3, P216, DOI 10.1038/nrn752
   Nillni EA, 2010, FRONT NEUROENDOCRIN, V31, P134, DOI 10.1016/j.yfrne.2010.01.001
   Nishikawa T, 2007, ANTIOXID REDOX SIGN, V9, P343, DOI 10.1089/ars.2006.1458
   Obata T, 1998, J BIOCHEM-TOKYO, V123, P813
   Obici S, 2002, NAT NEUROSCI, V5, P566, DOI 10.1038/nn861
   Obici S, 2002, NAT MED, V8, P1376, DOI 10.1038/nm798
   ODEA K, 1982, METABOLISM, V31, P896, DOI 10.1016/0026-0495(82)90178-0
   Ogden CL, 2007, GASTROENTEROLOGY, V132, P2087, DOI 10.1053/j.gastro.2007.03.052
   Oh-I S, 2006, NATURE, V443, P709, DOI 10.1038/nature05162
   Oh-I S, 2010, AM J PHYSIOL-ENDOC M, V299, pE47, DOI 10.1152/ajpendo.00026.2010
   Ono H, 2008, J CLIN INVEST, V118, P2959, DOI 10.1172/JCI34277
   Ozcan L, 2009, CELL METAB, V9, P35, DOI 10.1016/j.cmet.2008.12.004
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Pahl HL, 1999, ONCOGENE, V18, P6853, DOI 10.1038/sj.onc.1203239
   Paranjape SA, 2011, AM J PHYSIOL-ENDOC M, V301, pE978, DOI 10.1152/ajpendo.00304.2011
   Parekh S, 2007, GASTROENTEROLOGY, V132, P2191, DOI 10.1053/j.gastro.2007.03.055
   Parton LE, 2007, NATURE, V449, P228, DOI 10.1038/nature06098
   Paschen W, 2001, CELL CALCIUM, V29, P1, DOI 10.1054/ceca.2000.0162
   Perseghin G, 1997, J CLIN INVEST, V100, P931, DOI 10.1172/JCI119609
   Petersen KF, 2006, AM J MED, V119, p10S, DOI 10.1016/j.amjmed.2006.01.009
   Petersen KF, 2003, SCIENCE, V300, P1140, DOI 10.1126/science.1082889
   Pfluger PT, 2008, P NATL ACAD SCI USA, V105, P9793, DOI 10.1073/pnas.0802917105
   Picardi PK, 2008, ENDOCRINOLOGY, V149, P3870, DOI 10.1210/en.2007-1506
   Pickup JC, 1998, DIABETOLOGIA, V41, P1241, DOI 10.1007/s001250051058
   Pissios P, 2006, ENDOCR REV, V27, P606, DOI 10.1210/er.2006-0021
   PITTMAN JG, 1964, NEW ENGL J MED, V271, P403, DOI 10.1056/NEJM196408202710807
   Plata-Salamán CR, 1999, PSYCHONEUROENDOCRINO, V24, P25
   PlataSalaman CR, 1996, PHYSIOL BEHAV, V60, P867, DOI 10.1016/S0031-9384(96)00148-5
   Plum L, 2006, J CLIN INVEST, V116, P1761, DOI 10.1172/JCI29063
   Pocai A, 2006, J CLIN INVEST, V116, P1081, DOI 10.1172/JCI26640
   Poggi M, 2007, DIABETOLOGIA, V50, P1267, DOI 10.1007/s00125-007-0654-8
   Polak P, 2009, CURR OPIN CELL BIOL, V21, P209, DOI 10.1016/j.ceb.2009.01.024
   Polymenidou M, 2008, NATURE, V454, P284, DOI 10.1038/454284a
   Posey KA, 2009, AM J PHYSIOL-ENDOC M, V296, pE1003, DOI 10.1152/ajpendo.90377.2008
   Pospisilik JA, 2007, CELL, V131, P476, DOI 10.1016/j.cell.2007.08.047
   Poulain-Godefroy O, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/823486
   Powner DJ, 2008, CURR OPIN CRIT CARE, V14, P163, DOI 10.1097/MCC.0b013e3282f57528
   Prando R, 1998, DIABETES CARE, V21, P1680, DOI 10.2337/diacare.21.10.1680
   Pu S, 2000, J NEUROENDOCRINOL, V12, P827, DOI 10.1046/j.1365-2826.2000.00526.x
   Purkayastha S, 2011, NAT MED, V17, P883, DOI 10.1038/nm.2372
   Purkayastha S, 2011, P NATL ACAD SCI USA, V108, P2939, DOI 10.1073/pnas.1006875108
   Qadri F, 2002, CAN J PHYSIOL PHARM, V80, P258, DOI 10.1139/Y02-051
   Qi Y, 2006, DIABETES, V55, P3083, DOI 10.2337/db05-0615
   Rahmouni K, 2005, HYPERTENSION, V45, P9, DOI 10.1161/01.HYP.0000151325.83008.b4
   Rahmouni K, 2002, CURR HYPERTENS REP, V4, P119, DOI 10.1007/s11906-002-0036-z
   Rahmouni K, 2011, CELL METAB, V14, P3, DOI 10.1016/j.cmet.2011.06.006
   Ramadori G, 2011, CELL METAB, V14, P301, DOI 10.1016/j.cmet.2011.06.014
   Ramadori G, 2010, CELL METAB, V12, P78, DOI 10.1016/j.cmet.2010.05.010
   Ramadori G, 2009, ENDOCRINOLOGY, V150, P5326, DOI 10.1210/en.2009-0528
   Reed AS, 2010, DIABETES, V59, P894, DOI 10.2337/db09-1024
   Reed JA, 2005, J CLIN INVEST, V115, P3035, DOI 10.1172/JCI25681
   Ren DC, 2005, CELL METAB, V2, P95, DOI 10.1016/j.cmet.2005.07.004
   Ren J, 2010, J MOL MED, V88, P993, DOI 10.1007/s00109-010-0663-9
   Reyna SM, 2008, DIABETES, V57, P2595, DOI 10.2337/db08-0038
   Ringheim GE, 2006, CURR PHARM DESIGN, V12, P719, DOI 10.2174/138161206775474215
   Rodriguez A, 2007, J CLIN ENDOCR METAB, V92, P3568, DOI 10.1210/jc.2006-2764
   Romanatto T, 2007, PEPTIDES, V28, P1050, DOI 10.1016/j.peptides.2007.03.006
   Romanatto T, 2009, J BIOL CHEM, V284, P36213, DOI 10.1074/jbc.M109.030874
   Ropelle ER, 2010, PLOS BIOL, V8, DOI 10.1371/journal.pbio.1000465
   Rosen ED, 2006, NATURE, V444, P847, DOI 10.1038/nature05483
   Rossi J, 2011, CELL METAB, V13, P195, DOI 10.1016/j.cmet.2011.01.010
   Rui LY, 2002, J BIOL CHEM, V277, P42394, DOI 10.1074/jbc.C200444200
   Saberi M, 2009, CELL METAB, V10, P419, DOI 10.1016/j.cmet.2009.09.006
   Sabio G, 2008, SCIENCE, V322, P1539, DOI 10.1126/science.1160794
   Sabio G, 2010, TRENDS BIOCHEM SCI, V35, P490, DOI 10.1016/j.tibs.2010.04.004
   Sabio G, 2010, GENE DEV, V24, P256, DOI 10.1101/gad.1878510
   Sabio G, 2010, MOL CELL BIOL, V30, P106, DOI 10.1128/MCB.01162-09
   Sabio G, 2009, CELL METAB, V10, P491, DOI 10.1016/j.cmet.2009.09.007
   Saijo K, 2011, CELL, V145, P584, DOI 10.1016/j.cell.2011.03.050
   Sainsbury A, 2002, P NATL ACAD SCI USA, V99, P8938, DOI 10.1073/pnas.132043299
   Sakai K, 2005, CURR HYPERTENS REP, V7, P135, DOI 10.1007/s11906-005-0088-y
   Sandoval D, 2008, ANNU REV PHYSIOL, V70, P513, DOI 10.1146/annurev.physiol.70.120806.095256
   Savoia C, 2006, CURR OPIN NEPHROL HY, V15, P152, DOI 10.1097/01.mnh.0000203189.57513.76
   Scarlett JM, 2008, ENDOCRINOLOGY, V149, P4837, DOI 10.1210/en.2007-1680
   Scarlett JM, 2007, ENDOCRINOLOGY, V148, P4217, DOI 10.1210/en.2007-0017
   Schaefer S, 2008, EUR J ENDOCRINOL, V158, P3, DOI 10.1530/EJE-07-0484
   Schenk S, 2008, J CLIN INVEST, V118, P2992, DOI 10.1172/JCI34260
   Schwartz M, 1999, TRENDS NEUROSCI, V22, P295, DOI 10.1016/S0166-2236(99)01405-8
   Schwer B, 2010, P NATL ACAD SCI USA, V107, P21790, DOI 10.1073/pnas.1016306107
   Semenkovich CF, 2006, J CLIN INVEST, V116, P1813, DOI 10.1172/JCI29024
   Señarís RM, 2011, J NEUROENDOCRINOL, V23, P675, DOI 10.1111/j.1365-2826.2011.02158.x
   Sharpstone D, 1996, LANCET, V348, P379, DOI 10.1016/S0140-6736(96)01034-3
   Sharshar T, 2005, CRIT CARE, V9, P37, DOI 10.1186/cc2951
   Shi H, 2006, J CLIN INVEST, V116, P3015, DOI 10.1172/JCI28898
   Shimada M, 1998, NATURE, V396, P670, DOI 10.1038/25341
   Shin EA, 1999, FEBS LETT, V452, P355, DOI 10.1016/S0014-5793(99)00657-2
   Shoelson SE, 2009, NAT MED, V15, P373, DOI 10.1038/nm0409-373
   Singhal NS, 2007, J NEUROSCI, V27, P12924, DOI 10.1523/JNEUROSCI.2443-07.2007
   SLUKA KA, 1994, J PHARMACOL EXP THER, V271, P76
   Solinas G, 2007, CELL METAB, V6, P386, DOI 10.1016/j.cmet.2007.09.011
   Somm E, 2005, DIABETES, V54, P3503, DOI 10.2337/diabetes.54.12.3503
   Song YS, 2010, J CEREBR BLOOD F MET, V30, P1265, DOI 10.1038/jcbfm.2010.6
   Song ZT, 2001, DIABETES, V50, P2673, DOI 10.2337/diabetes.50.12.2673
   Sonoda J, 2008, FEBS LETT, V582, P2, DOI 10.1016/j.febslet.2007.11.016
   SPIEGELMAN BM, 1993, CELL, V73, P625, DOI 10.1016/0092-8674(93)90243-J
   Spiegelman BM, 2001, CELL, V104, P531, DOI 10.1016/S0092-8674(01)00240-9
   Stanley TL, 2011, J CLIN ENDOCR METAB, V96, pE146, DOI 10.1210/jc.2010-1170
   Ste Marie L, 2000, P NATL ACAD SCI USA, V97, P12339, DOI 10.1073/pnas.220409497
   Stefater MA, 2010, ANNU REV NUTR, V30, P219, DOI 10.1146/annurev.nutr.012809.104723
   Szegezdi E, 2009, AM J PHYSIOL-CELL PH, V296, pC941, DOI 10.1152/ajpcell.00612.2008
   Taghibiglou C, 2002, J BIOL CHEM, V277, P793, DOI 10.1074/jbc.M106737200
   Takeuchi O, 2010, CELL, V140, P805, DOI 10.1016/j.cell.2010.01.022
   Tang T, 2010, J BIOL CHEM, V285, P4637, DOI 10.1074/jbc.M109.068007
   Tapia-González S, 2011, J NEUROENDOCRINOL, V23, P365, DOI 10.1111/j.1365-2826.2011.02113.x
   Thaler JP, 2010, ENDOCRINOLOGY, V151, P4109, DOI 10.1210/en.2010-0336
   Thaler JP, 2010, FRONT NEUROENDOCRIN, V31, P79, DOI 10.1016/j.yfrne.2009.10.002
   Tirone TA, 2001, WORLD J SURG, V25, P461, DOI 10.1007/s002680020338
   Tong QC, 2008, NAT NEUROSCI, V11, P998, DOI 10.1038/nn.2167
   Tong QC, 2007, CELL METAB, V5, P383, DOI 10.1016/j.cmet.2007.04.001
   Tsukumo DML, 2007, DIABETES, V56, P1986, DOI 10.2337/db06-1595
   Um SH, 2004, NATURE, V431, P200, DOI 10.1038/nature02866
   Unger EK, 2010, ENDOCRINOLOGY, V151, P671, DOI 10.1210/en.2009-0711
   Uysal KT, 1997, NATURE, V389, P610, DOI 10.1038/39335
   Vaag A, 2007, APPL PHYSIOL NUTR ME, V32, P912, DOI 10.1139/H07-100
   Vallerie SN, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0003151
   Vallerie SN, 2010, SCI TRANSL MED, V2, DOI 10.1126/scitranslmed.3001007
   Van Gaal LF, 2006, NATURE, V444, P875, DOI 10.1038/nature05487
   Vázquez MJ, 2008, ENDOCRINOLOGY, V149, P4534, DOI 10.1210/en.2007-1708
   Ventre J, 1997, DIABETES, V46, P1526, DOI 10.2337/diabetes.46.9.1526
   Vianna CR, 2006, CELL METAB, V4, P453, DOI 10.1016/j.cmet.2006.11.003
   Virtue S, 2011, PLOS BIOL, V9, DOI 10.1371/journal.pbio.1001116
   Viveros M. P., 2008, Endocrine Metabolic & Immune Disorders-Drug Targets, V8, P220, DOI 10.2174/187153008785700082
   Vong L, 2011, NEURON, V71, P142, DOI 10.1016/j.neuron.2011.05.028
   Wallenius K, 2002, BIOCHEM BIOPH RES CO, V293, P560, DOI 10.1016/S0006-291X(02)00230-9
   Wallenius V, 2002, NAT MED, V8, P75, DOI 10.1038/nm0102-75
   Wang H, 2011, CELL METAB, V13, P105, DOI 10.1016/j.cmet.2010.12.006
   Watt MJ, 2006, NAT MED, V12, P541, DOI 10.1038/nm1383
   Weichhart T, 2008, IMMUNITY, V29, P565, DOI 10.1016/j.immuni.2008.08.012
   Weseler AR, 2010, CURR HYPERTENS REP, V12, P154, DOI 10.1007/s11906-010-0103-9
   Weston CR, 2007, CURR OPIN CELL BIOL, V19, P142, DOI 10.1016/j.ceb.2007.02.001
   Williams KW, 2011, EUR J PHARMACOL, V660, P2, DOI 10.1016/j.ejphar.2010.11.042
   Wisloff U, 2005, SCIENCE, V307, P418, DOI 10.1126/science.1108177
   Won JC, 2009, OBESITY, V17, P1861, DOI 10.1038/oby.2009.194
   Wouters BG, 2008, NAT REV CANCER, V8, P851, DOI 10.1038/nrc2501
   Wu KIS, 2011, HYPERTENSION, V57, P261, DOI 10.1161/HYPERTENSIONAHA.110.158709
   Wullschleger S, 2006, CELL, V127, P5
   Xu BJ, 2003, NAT NEUROSCI, V6, P736, DOI 10.1038/nn1073
   Xu Y, 2008, NEURON, V60, P582, DOI 10.1016/j.neuron.2008.09.033
   Xue BZ, 2006, J PHYSIOL-LONDON, V574, P73, DOI 10.1113/jphysiol.2006.113217
   Yadav A, 2009, J NEUROIMMUNE PHARM, V4, P430, DOI 10.1007/s11481-009-9174-2
   Yaguchi M, 2003, NEUROPATHOLOGY, V23, P44, DOI 10.1046/j.1440-1789.2003.00475.x
   Yamamoto Y, 2010, J NEUROIMMUNOL, V229, P129, DOI 10.1016/j.jneuroim.2010.07.024
   Yamauchi T, 2007, NAT MED, V13, P332, DOI 10.1038/nm1557
   Yang L, 2010, CELL METAB, V11, P467, DOI 10.1016/j.cmet.2010.04.005
   Yi CX, 2011, NEUROENDOCRINOLOGY, V93, P143, DOI 10.1159/000324888
   Yorimitsu T, 2005, CELL DEATH DIFFER, V12, P1542, DOI 10.1038/sj.cdd.4401765
   Zabolotny JM, 2008, J BIOL CHEM, V283, P14230, DOI 10.1074/jbc.M800061200
   Zhang KZ, 2008, NATURE, V454, P455, DOI 10.1038/nature07203
   Zhang R, 2008, ENDOCRINOLOGY, V149, P5654, DOI 10.1210/en.2008-0805
   Zhang XQ, 2008, CELL, V135, P61, DOI 10.1016/j.cell.2008.07.043
   Zhang ZH, 2010, J HYPERTENS, V28, P806, DOI 10.1097/HJH.0b013e3283358b6e
   Zheng JY, 2005, AGING CELL, V4, P209, DOI 10.1111/j.1474-9726.2005.00159.x
   Zhou RB, 2011, NATURE, V469, P221, DOI 10.1038/nature09663
   Zimmet P, 2001, NATURE, V414, P782, DOI 10.1038/414782a
   Zoncu R, 2011, NAT REV MOL CELL BIO, V12, P21, DOI 10.1038/nrm3025
   Zorriila EP, 2007, P NATL ACAD SCI USA, V104, P11097, DOI 10.1073/pnas.0611523104
   Zucker IH, 2002, CIRC RES, V90, P503, DOI 10.1161/01.RES.0000014287.96335.21
NR 411
TC 131
Z9 146
U1 1
U2 20
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
BN 978-1-57331-847-1
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2011
VL 1243
BP E1
EP E39
DI 10.1111/j.1749-6632.2011.06388.x
PG 39
WC Endocrinology & Metabolism; Multidisciplinary Sciences
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Science & Technology - Other Topics
GA BZG28
UT WOS:000301504400001
PM 22417140
OA hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Hu, MX
   Lamers, F
   de Geus, EJC
   Penninx, BWJH
AF Hu, Mandy Xian
   Lamers, Femke
   de Geus, Eco J. C.
   Penninx, Brenda W. J. H.
TI Influences of lifestyle factors on cardiac autonomic nervous system
   activity over time
SO PREVENTIVE MEDICINE
LA English
DT Article
DE Autonomic nervous system; Lifestyle; Physical activity; Alcohol use;
   Smoking
ID HEART-RATE-VARIABILITY; AMBULATORY BLOOD-PRESSURE; CIGARETTE-SMOKING;
   PHYSICAL-ACTIVITY; METABOLIC SYNDROME; ALCOHOL-CONSUMPTION; RISK-FACTOR;
   SHORT-TERM; EXERCISE; DEPRESSION
AB Physical activity, alcohol use and smoking might affect cardiovascular disease through modifying autonomic nervous system (ANS) activity. We investigated: 1) whether there are consistent relationships between lifestyle factors and cardiac ANS activity over time, and 2) whether 2-year changes in lifestyle factors relate to 2-year changes in cardiac activity. Baseline (n = 2618) and 2-year follow-up (n = 2010) data of the Netherlands Study of Depression and Anxiety was combined. Baseline data was collected in the Netherlands from 2004-2007. Lifestyle factors were habitual physical activity, frequency of sport activities, alcohol use, and smoking. Indicators of cardiac activity were heart rate (HR), respiratory sinus arrhythmia (RSA) and pre-ejection period (PEP) (100 min of registration). The results showed that high physical activity (-1.8 beats/min compared to low activity), high frequency of sport activities ('couple of times/week': -2.5 beats/min compared to 'almost never') and mild/moderate alcohol use (-1.2 beats/min compared to non-drinking) were related to low HR. Heavy smoking was related to high HR (> 30 cigarettes/day: +5.1 beats/min compared to non- smoking). High frequency of sport activities was associated with high RSA ('couple of times/week': +1.7 ms compared to 'almost never') and moderate smoking with longer PEP (11-20 cigarettes/day: +2.8 ms compared to non-smoking). Associations were consistent across waves. Furthermore, 2-year change in frequency of sport activities and number of smoked cigarettes/day was accompanied by 2-year change in HR (beta = -0.076 and beta = 0.101, respectively) and RSA (beta = 0.046 and beta = -0.040, respectively). Our findings support consistent effects of lifestyle on HR and parasympathetic activity in the expected direction. Cardiac autonomic dysregulation may be partly mediating the relationship between lifestyle and subsequent cardiovascular health. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Hu, Mandy Xian; Lamers, Femke; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Amsterdam, Netherlands.
   [Hu, Mandy Xian; Lamers, Femke; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
   [de Geus, Eco J. C.] Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands.
   [de Geus, Eco J. C.] Vrije Univ Amsterdam, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; Vrije
   Universiteit Amsterdam; Vrije Universiteit Amsterdam
RP Hu, MX (corresponding author), AJ Ernststr 1187, NL-1081 HL Amsterdam, Netherlands.
EM m.hu@ggzingeest.nl
RI Penninx, Brenda/S-7627-2017; Lamers, Femke/G-5161-2012; de Geus,
   Eco/M-9318-2015
OI de Geus, Eco/0000-0001-6022-2666; Hu, Mandy Xian/0000-0002-4496-8772;
   Lamers, Femke/0000-0003-4344-5766
FU Geestkracht program of the Netherlands Organisation for Health Research
   and Development [10000-1002]; VU University Medical Center, Leiden
   University Medical Center, University Medical Center Groningen; European
   Union Seventh Framework Programme(FP7) [PCIG12-GA-2012-334065]
FX The infrastructure for the NESDA study (www.nesda.nl) has been funded
   through the Geestkracht program of the Netherlands Organisation for
   Health Research and Development (Zon-Mw, grant number 10000-1002) and
   participating universities (VU University Medical Center, Leiden
   University Medical Center, University Medical Center Groningen). FL has
   received funding from the European Union Seventh Framework Programme
   (FP7/2007-2013) under grant agreement no: PCIG12-GA-2012-334065. BP has
   received-unrelated-grant funding from Jansen.
CR Alyan O., 2008, ANN
   Amano M, 2001, MED SCI SPORT EXER, V33, P1287, DOI 10.1097/00005768-200108000-00007
   Babor T., 1992, The Alcohol Use Identification Test (AUDIT): Guidelines for use in primary health care
   Barutcu I., 2005, ANN
   Boschloo L, 2011, DRUG ALCOHOL DEPEN, V116, P170, DOI 10.1016/j.drugalcdep.2010.12.006
   Brunner EJ, 2002, CIRCULATION, V106, P2659, DOI 10.1161/01.CIR.0000038364.26310.BD
   Carter JB, 2003, SPORTS MED, V33, P33, DOI 10.2165/00007256-200333010-00003
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   Curtis BM, 2002, MAYO CLIN PROC, V77, P45, DOI 10.4065/77.1.45
   de Geus E. J. C., 1996, Ambulatory Assessment. Computer Assisted Psychological and Psychophysiological Methods in Monitoring and Field Studies, P141
   DEGEUS EJC, 1995, BIOL PSYCHOL, V41, P205, DOI 10.1016/0301-0511(95)05137-6
   Dinas PC, 2013, INT J CARDIOL, V163, P109, DOI 10.1016/j.ijcard.2011.10.140
   Eryonucu B., 2000, ACTA CARDIOL
   Goldsmith RL, 2000, CORONARY ARTERY DIS, V11, P129, DOI 10.1097/00019501-200003000-00007
   GRASSI G, 1994, HYPERTENSION, V23, P294, DOI 10.1161/01.HYP.23.3.294
   Grassi G, 2015, CIRC RES, V116, P976, DOI 10.1161/CIRCRESAHA.116.303604
   GRONBAEK M, 1995, BRIT MED J, V310, P1165, DOI 10.1136/bmj.310.6988.1165
   Haass M, 1997, CARDIOVASC DRUG THER, V10, P657, DOI 10.1007/BF00053022
   HAYANO J, 1990, AM J CARDIOL, V65, P84, DOI 10.1016/0002-9149(90)90030-5
   HEATHERTON TF, 1989, BRIT J ADDICT, V84, P791
   Hering D, 2010, BLOOD PRESSURE, V19, P152, DOI 10.3109/08037051.2010.484150
   HIRSCH JA, 1981, AM J PHYSIOL, V241, pH620, DOI 10.1152/ajpheart.1981.241.4.H620
   Houtveen JH, 2005, PSYCHOPHYSIOLOGY, V42, P713, DOI 10.1111/j.1469-8986.2005.00363.x
   Hu MX, 2016, PSYCHONEUROENDOCRINO, V71, P119, DOI 10.1016/j.psyneuen.2016.05.018
   Hu MX, 2016, PSYCHOSOM MED, V78, P562, DOI 10.1097/PSY.0000000000000313
   Iwane M, 2000, HYPERTENS RES, V23, P573, DOI 10.1291/hypres.23.573
   Iwasaki K, 2003, J APPL PHYSIOL, V95, P1575, DOI 10.1152/japplphysiol.00482.2003
   Joyner MJ, 2009, J PHYSIOL-LONDON, V587, P5551, DOI 10.1113/jphysiol.2009.179432
   KIILAVUORI K, 1995, EUR HEART J, V16, P490
   Kop WJ, 2010, PSYCHOSOM MED, V72, P626, DOI 10.1097/PSY.0b013e3181eadd2b
   Koppes LLJ, 2005, DIABETES CARE, V28, P719, DOI 10.2337/diacare.28.3.719
   Koskinen T, 2009, DIABETIC MED, V26, P354, DOI 10.1111/j.1464-5491.2009.02686.x
   LAROVERE MT, 1992, CHEST, V101, pS299, DOI 10.1378/chest.101.5.299S
   LAUSTIOLA KE, 1988, CIRCULATION, V78, P1234, DOI 10.1161/01.CIR.78.5.1234
   Licht CMM, 2009, PSYCHOSOM MED, V71, P508, DOI 10.1097/PSY.0b013e3181a292a6
   Licht CMM, 2008, ARCH GEN PSYCHIAT, V65, P1358, DOI 10.1001/archpsyc.65.12.1358
   Lloyd-Jones DM, 2006, CIRCULATION, V113, P791, DOI 10.1161/CIRCULATIONAHA.105.548206
   Lucini D, 1996, CARDIOVASC RES, V31, P633
   Melo RC, 2005, BRAZ J MED BIOL RES, V38, P1331, DOI 10.1590/S0100-879X2005000900007
   Middlekauff HR, 2014, J AM COLL CARDIOL, V64, P1740, DOI 10.1016/j.jacc.2014.06.1201
   Molgaard H., 1991, AM J
   Mueller PJ, 2007, CLIN EXP PHARMACOL P, V34, P377, DOI 10.1111/j.1440-1681.2007.04590.x
   Narkiewicz K, 1998, CIRCULATION, V98, P528, DOI 10.1161/01.CIR.98.6.528
   NIEDERMAIER ON, 1993, CIRCULATION, V88, P562, DOI 10.1161/01.CIR.88.2.562
   Ohira T, 2009, HYPERTENSION, V53, P13, DOI 10.1161/HYPERTENSIONAHA.108.114835
   Okazaki K, 2005, J APPL PHYSIOL, V99, P1041, DOI 10.1152/japplphysiol.00085.2005
   Penninx BWJH, 2008, INT J METH PSYCH RES, V17, P121, DOI 10.1002/mpr.256
   Pope CA, 2001, ENVIRON HEALTH PERSP, V109, P711, DOI 10.2307/3454788
   Poulsen PL, 1998, AM J HYPERTENS, V11, P1093, DOI 10.1016/S0895-7061(98)00115-0
   Reed SF, 1999, EXP CLIN PSYCHOPHARM, V7, P484, DOI 10.1037/1064-1297.7.4.484
   Rennie KL, 2003, AM J EPIDEMIOL, V158, P135, DOI 10.1093/aje/kwg120
   Rosenwinkel Eric T., 2001, Cardiology Clinics, V19, P369, DOI 10.1016/S0733-8651(05)70223-X
   Ryan JM, 2002, HEART, V88, P641, DOI 10.1136/heart.88.6.641
   Rzewnicki R, 2003, PUBLIC HEALTH NUTR, V6, P299, DOI 10.1079/PHN2002427
   Sagawa Y, 2011, ALCOHOL CLIN EXP RES, V35, P2093, DOI 10.1111/j.1530-0277.2011.01558.x
   Shinozaki N, 2008, INT HEART J, V49, P261, DOI 10.1536/ihj.49.261
   Sjoberg N, 2011, NICOTINE TOB RES, V13, P369, DOI 10.1093/ntr/ntr004
   Soares-Miranda L, 2012, DIABETES-METAB RES, V28, P363, DOI 10.1002/dmrr.2281
   Spaak J, 2010, AM J PHYSIOL-HEART C, V298, pH2226, DOI 10.1152/ajpheart.00700.2009
   Thorp AA, 2015, J DIABETES RES, V2015, DOI 10.1155/2015/341583
   Ueno LM, 2003, EUR J APPL PHYSIOL, V89, P109, DOI 10.1007/s00421-002-0777-z
   van Lien R, 2015, PSYCHOPHYSIOLOGY, V52, P225, DOI [10.1111/psyp.12300, 10.1111/psyp.12246]
   van Lien R, 2011, INT J PSYCHOPHYSIOL, V81, P169, DOI 10.1016/j.ijpsycho.2011.06.007
   Vaschillo EG, 2008, PSYCHOPHYSIOLOGY, V45, P847, DOI 10.1111/j.1469-8986.2008.00673.x
   Vrijkotte TGM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0138302
   WANNAMETHEE G, 1988, INT J EPIDEMIOL, V17, P307, DOI 10.1093/ije/17.2.307
   Wichi RB, 2009, CLINICS, V64, P253, DOI 10.1590/S1807-59322009000300017
NR 67
TC 24
Z9 27
U1 2
U2 24
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
EI 1096-0260
J9 PREV MED
JI Prev. Med.
PD JAN
PY 2017
VL 94
BP 12
EP 19
DI 10.1016/j.ypmed.2016.11.003
PG 8
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA EO0ER
UT WOS:000396371600003
PM 27836526
OA Green Published
DA 2025-06-11
ER

PT J
AU Tain, YL
   Lin, YJ
   Hsu, CN
AF Tain, You-Lin
   Lin, Ying-Jui
   Hsu, Chien-Ning
TI Breastfeeding and Future Cardiovascular, Kidney, and Metabolic Health-A
   Narrative Review
SO NUTRIENTS
LA English
DT Review
DE breastfeeding; lactation; developmental origins of health and disease
   (DOHaD); microbiota; kidney disease; cardiovascular disease; metabolic
   syndrome; milk composition
ID TAURINE SUPPLEMENTATION PREVENTS; MATERNAL NICOTINE EXPOSURE;
   HUMAN-MILK; OXIDATIVE STRESS; BLOOD-PRESSURE; UTEROPLACENTAL
   INSUFFICIENCY; PROGRAMMED HYPERTENSION; PROLACTIN INHIBITION; INSULIN
   SENSITIVITY; RENAL DYSFUNCTION
AB The benefits of breastfeeding for both mother and infant are generally recognized; however, the connections between breast milk, lactation, and long-term offspring health and disease remain incompletely understood. Cardiovascular-kidney-metabolic syndrome (CKMS) has become a major global public health challenge. Insufficient breast milk supply, combined with various early-life environmental factors, markedly increases the future risk of CKMS, as highlighted by the developmental origins of health and disease (DOHaD) concept. Given its richness in nutrients and bioactive components essential for infant health, this review focuses on reprogramming strategies involving breast milk to improve offspring's cardiovascular, kidney, and metabolic health. It also highlights recent experimental advances in understanding the mechanisms driving CKMS programming. Cumulatively, the evidence suggests that lactational impairment heightens the risk of CKMS development. In contrast, early interventions during the lactation period focused on animal models that leverage breast milk components in response to early-life cues show potential in improving cardiovascular, kidney, and metabolic outcomes-an area warranting further investigation and clinical translation.
C1 [Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Div Pediat Nephrol, Kaohsiung 833, Taiwan.
   [Tain, You-Lin] Chang Gung Univ, Coll Med, Taoyuan 333, Taiwan.
   [Tain, You-Lin] Kaohsiung Municipal Tatung Hosp, Dept Pediat, Kaohsiung 801, Taiwan.
   [Lin, Ying-Jui] Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Div Crit Care, Kaohsiung 833, Taiwan.
   [Lin, Ying-Jui] Chang Gung Univ, Coll Med, Kaohsiung 833, Taiwan.
   [Lin, Ying-Jui] Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Div Cardiol, Kaohsiung 833, Taiwan.
   [Lin, Ying-Jui] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Dept Resp Therapy, Coll Med, Kaohsiung 833, Taiwan.
   [Lin, Ying-Jui] Cheng Shiu Univ, Dept Early Childhood Care & Educ, Kaohsiung 833, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Med Univ, Sch Pharm, Kaohsiung 807, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Kaohsiung Medical
   University; Kaohsiung Municipal Ta-Tung Hospital; Chang Gung Memorial
   Hospital; Chang Gung University; Chang Gung Memorial Hospital; Chang
   Gung University; Chang Gung Memorial Hospital; Cheng Shiu University;
   Chang Gung Memorial Hospital; Kaohsiung Medical University
RP Hsu, CN (corresponding author), Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan.; Hsu, CN (corresponding author), Kaohsiung Med Univ, Sch Pharm, Kaohsiung 807, Taiwan.
EM tainyl@cgmh.org.tw; rayray@cgmh.org.tw; cnhsu@cgmh.org.tw
RI Tain, You-Lin/H-2827-2019; Hsu, Chien-Ning/GLS-4014-2022
OI Hsu, Chien-Ning/0000-0001-7470-528X
FU National Science and Technology Council, Taiwan; Kaohsiung Chang Gung
   Memorial Hospital, Kaohsiung, Taiwan [CORPG8M0351]; 
   [113-2314-B-182A-118]
FX This work was supported by financial assistance from the National
   Science and Technology Council, Taiwan, under grant number
   113-2314-B-182A-118, and Kaohsiung Chang Gung Memorial Hospital,
   Kaohsiung, Taiwan, under grant number CORPG8M0351.
CR Addi T, 2018, TOXINS, V10, DOI 10.3390/toxins10100412
   Adegoke EO, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22083939
   Aggarwal R, 2024, JAMA-J AM MED ASSOC, V331, P1858, DOI 10.1001/jama.2024.6892
   Ahern GJ, 2019, ANNU REV FOOD SCI T, V10, P75, DOI 10.1146/annurev-food-081318-104308
   Al Khodor S, 2017, PEDIATR NEPHROL, V32, P921, DOI 10.1007/s00467-016-3392-7
   Alexander BT, 2023, HYPERTENSION, V80, pE75, DOI 10.1161/HYP.0000000000000227
   Alsaweed M, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0152610
   Alsaweed M, 2015, INT J ENV RES PUB HE, V12, P13981, DOI 10.3390/ijerph121113981
   American Academy of Pediatrics Committee on Fetus and Newborn, 2003, Pediatrics, V112, P191
   Ananthan A, 2022, EUR J PEDIATR, V181, P1821, DOI 10.1007/s00431-022-04394-y
   Andreas NJ, 2015, EARLY HUM DEV, V91, P629, DOI 10.1016/j.earlhumdev.2015.08.013
   Aragon AC, 2008, TOXICOL SCI, V101, P321, DOI 10.1093/toxsci/kfm272
   Arrieta MC, 2014, FRONT IMMUNOL, V5, DOI 10.3389/fimmu.2014.00427
   ARTHUR PG, 1991, J PEDIATR GASTR NUTR, V13, P260, DOI 10.1097/00005176-199110000-00004
   Barker DJP, 2002, INT J EPIDEMIOL, V31, P1235, DOI 10.1093/ije/31.6.1235
   Baxi DB, 2012, J MATERN-FETAL NEO M, V25, P1574, DOI 10.3109/14767058.2011.648235
   Beenken A, 2009, NAT REV DRUG DISCOV, V8, P235, DOI 10.1038/nrd2792
   Berger PK, 2020, CURR OPIN CLIN NUTR, V23, P277, DOI 10.1097/MCO.0000000000000658
   Berger PK, 2018, NUTRIENTS, V10, DOI 10.3390/nu10060669
   Berger S, 2024, ANAL BIOANAL CHEM, V416, P1821, DOI 10.1007/s00216-024-05179-y
   Berleze KJ, 2009, EXP BIOL MED, V234, P1437, DOI 10.3181/0903-RM-111
   Bianco-Miotto T, 2017, J DEV ORIG HLTH DIS, V8, P513, DOI 10.1017/S2040174417000733
   Binns C, 2016, ASIA-PAC J PUBLIC HE, V28, P7, DOI 10.1177/1010539515624964
   Boubred F, 2009, AM J PHYSIOL-RENAL, V297, pF943, DOI 10.1152/ajprenal.90704.2008
   Boulangé CL, 2016, GENOME MED, V8, DOI 10.1186/s13073-016-0303-2
   Bravi F, 2016, AM J CLIN NUTR, V104, P646, DOI 10.3945/ajcn.115.120881
   Caba-Flores MD, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.867507
   Cabral EV, 2019, CLIN EXP PHARMACOL P, V46, P1151, DOI 10.1111/1440-1681.13161
   Canani RB, 2011, NUTR RES REV, V24, P198, DOI 10.1017/S0954422411000102
   Carlson Z, 2020, AM J PHYSIOL-ENDOC M, V318, pE600, DOI 10.1152/ajpendo.00473.2019
   Collado MC, 2012, GUT MICROBES, V3, P352, DOI 10.4161/gmic.21215
   Carretero-Krug A, 2024, NUTRIENTS, V16, DOI 10.3390/nu16020301
   Castillo P, 2023, NUTRIENTS, V15, DOI 10.3390/nu15030570
   Chang HY, 2016, STEROIDS, V108, P1, DOI 10.1016/j.steroids.2016.02.017
   Chao YM, 2020, J BIOMED SCI, V27, DOI 10.1186/s12929-020-00660-z
   Chao Yung-Mei, 2016, Shengli Xuebao, V68, P557, DOI 10.13294/j.aps.2016.0064
   Chen CM, 2015, PEDIATR RES, V77, P56, DOI 10.1038/pr.2014.148
   Chen L, 2004, J APPL PHYSIOL, V96, P167, DOI 10.1152/japplphysiol.00751.2003
   Chong E, 2012, INT J NEPHROL, V2012, DOI 10.1155/2012/760580
   Conceiçao EP, 2015, FOOD CHEM TOXICOL, V78, P52, DOI 10.1016/j.fct.2015.01.025
   Conceiçao EPS, 2013, J NUTR BIOCHEM, V24, P81, DOI 10.1016/j.jnutbio.2012.02.010
   Cynober L, 2010, CLIN NUTR, V29, P545, DOI 10.1016/j.clnu.2010.07.006
   Davis LMG, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025200
   Davis MK, 2001, PEDIATR CLIN N AM, V48, P125, DOI 10.1016/S0031-3955(05)70289-3
   Dimova LG, 2017, GASTROENTEROLOGY, V153, P382, DOI 10.1053/j.gastro.2017.04.019
   Domellöf M, 2004, AM J CLIN NUTR, V79, P111
   Ducker GS, 2017, CELL METAB, V25, P27, DOI 10.1016/j.cmet.2016.08.009
   Edwards CA, 2022, BENEF MICROBES, V13, P365, DOI 10.3920/BM2021.0098
   EL-Khuffash A, 2020, PEDIATR RES, V87, P385, DOI 10.1038/s41390-019-0648-5
   Fan Y, 2021, NAT REV MICROBIOL, V19, P55, DOI 10.1038/s41579-020-0433-9
   Farah E, 2021, J MIDWIFERY WOM HEAL, V66, P631, DOI 10.1111/jmwh.13274
   Fernandez-Vaz C, 2022, BREASTFEED MED, V17, P984, DOI 10.1089/bfm.2022.0165
   Fields DA, 2016, OBESITY, V24, P1213, DOI 10.1002/oby.21519
   Franco MD, 2009, LIFE SCI, V85, P327, DOI 10.1016/j.lfs.2009.06.013
   Galyon KD, 2017, AM J OBSTET GYNECOL, V216, DOI 10.1016/j.ajog.2016.08.041
   Ganu RS, 2012, ILAR J, V53, P306, DOI 10.1093/ilar.53.3-4.306
   German JB, 2008, NESTLE NUTR WORKS SE, V62, P205, DOI 10.1159/000146322
   GILBERT T, 1990, PEDIATR NEPHROL, V4, P445, DOI 10.1007/BF00862534
   Gluckman PD, 2010, J DEV ORIG HLTH DIS, V1, P6, DOI 10.1017/S2040174409990171
   Golan-Gerstl R, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201700009
   Gray C, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0115994
   Gray C, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0053505
   Gregg B, 2022, PEDIATR OBES, V17, DOI 10.1111/ijpo.12892
   Gregório BM, 2008, AM J OBSTET GYNECOL, V199, DOI 10.1016/j.ajog.2007.12.016
   Gueler MS, 2025, FOOD RES INT, V199, DOI 10.1016/j.foodres.2024.115420
   Gunn AJ, 1996, PEDIATRICS, V98, P279
   Hägg S, 2000, DRUG SAFETY, V22, P425, DOI 10.2165/00002018-200022060-00002
   Hausenloy DJ, 2009, CARDIOVASC RES, V83, P179, DOI 10.1093/cvr/cvp062
   Hills RD, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071613
   Hinde K, 2015, SCIENCE, V348, P1427, DOI 10.1126/science.aac7436
   Holemans K, 1996, J SOC GYNECOL INVEST, V3, P71, DOI 10.1016/1071-5576(95)00046-1
   Houghteling PD, 2015, J PEDIATR GASTR NUTR, V60, P294, DOI 10.1097/MPG.0000000000000597
   Hsu CN, 2022, J NUTR BIOCHEM, V108, DOI 10.1016/j.jnutbio.2022.109090
   Hsu CN, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11030483
   Hsu CN, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222111872
   Hsu CN, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10091393
   Hsu CN, 2021, MOL NUTR FOOD RES, V65, DOI 10.1002/mnfr.202001116
   Hsu CN, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21197237
   Hsu CN, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20184382
   Hsu CN, 2018, NUTRIENTS, V10, DOI 10.3390/nu10091229
   Hsu CN, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19082459
   Hurley WL, 2011, NUTRIENTS, V3, P442, DOI 10.3390/nu3040442
   Isganaitis E, 2019, AM J CLIN NUTR, V110, P111, DOI 10.1093/ajcn/nqy334
   Jenness R., 1979, The composition of human milk Seminars in Perinatology, V225, P239
   Jia LL, 2020, J AGR FOOD CHEM, V68, P3112, DOI 10.1021/acs.jafc.9b07701
   Jung SW, 2020, AM J PHYSIOL-RENAL, V318, pF1327, DOI 10.1152/ajprenal.00272.2019
   Kelishadi Roya, 2014, Adv Biomed Res, V3, P3, DOI 10.4103/2277-9175.124629
   Kim J, 2023, LIPIDS HEALTH DIS, V22, DOI 10.1186/s12944-023-01812-4
   Kim SY, 2020, CLIN EXP PEDIATR, V63, P301
   Kim YJ, 2021, PEDIATR GASTROENTERO, V24, P337, DOI 10.5223/pghn.2021.24.4.337
   Koletzko B, 1999, J MAMMARY GLAND BIOL, V4, P269, DOI 10.1023/A:1018749913421
   Kumar H, 2014, MBIO, V5, DOI 10.1128/mBio.02113-14
   LaKind JS, 2018, ENVIRON HEALTH PERSP, V126, DOI [10.1289/ehp1954, 10.1289/EHP1954]
   Lamana GL, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.658431
   Lamothe J, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10040531
   LeMay-Nedjelski L, 2021, J NUTR, V151, P320, DOI 10.1093/jn/nxaa248
   Li L, 2023, NUTR RES PRACT, V17, P1084, DOI 10.4162/nrp.2023.17.6.1084
   Liao JX, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22105273
   Lim YJ, 2021, TOXINS, V13, DOI 10.3390/toxins13020142
   Lisboa PC, 2010, HORM METAB RES, V42, P562, DOI 10.1055/s-0030-1253434
   Lisboa PC, 2021, NEUROPHARMACOLOGY, V200, DOI 10.1016/j.neuropharm.2021.108821
   Lönnerdal B, 2019, NESTLE NUTR WORKS SE, V90, P83, DOI 10.1159/000490297
   Gomes PRL, 2021, GEN COMP ENDOCR, V300, DOI 10.1016/j.ygcen.2020.113633
   Lowry DE, 2022, BRIT J NUTR, V127, P335, DOI 10.1017/S0007114521001197
   Luo KJ, 2017, EXP THER MED, V14, P2355, DOI 10.3892/etm.2017.4731
   Lyons KE, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041039
   Masi AC, 2024, MICROB BIOTECHNOL, V17, DOI 10.1111/1751-7915.14520
   Massy ZA, 2024, KIDNEY INT REP, V9, P2608, DOI 10.1016/j.ekir.2024.05.033
   Matamoros S, 2013, TRENDS MICROBIOL, V21, P167, DOI 10.1016/j.tim.2012.12.001
   Mazur D, 2023, CURR ISSUES MOL BIOL, V45, P9003, DOI 10.3390/cimb45110565
   McGowan C, 2023, BREASTFEED MED, V18, P172, DOI 10.1089/bfm.2022.0192
   Melnik B.C., 2017, Handbook of Nutrition, Diet, and Epigenetics, P1
   Melnik BC, 2021, BIOMOLECULES, V11, DOI 10.3390/biom11060851
   Melnik BC, 2017, BEST PRACT RES CL EN, V31, P427, DOI 10.1016/j.beem.2017.10.003
   Milani C, 2017, MICROBIOL MOL BIOL R, V81, DOI 10.1128/MMBR.00036-17
   Mitoulas LR, 2002, BRIT J NUTR, V88, P29, DOI [10.1079/BJN2002579, 10.1079/BJNBJN2002579]
   Moritz KM, 2010, PLACENTA, V31, pS40, DOI 10.1016/j.placenta.2010.01.006
   Nagel EM, 2024, JAMA NETW OPEN, V7, DOI 10.1001/jamanetworkopen.2024.50467
   Ndumele CE, 2023, CIRCULATION, V148, P1606, DOI 10.1161/CIR.0000000000001184
   Niki E, 2014, FREE RADICAL BIO MED, V66, P3, DOI 10.1016/j.freeradbiomed.2013.03.022
   Nuesken KD, 2008, ENDOCRINOLOGY, V149, P1056, DOI 10.1210/en.2007-0891
   Nuzzi G, 2021, MINERVA PEDIATR, V73, P111, DOI 10.23736/S2724-5276.21.06223-X
   O'Dowd R, 2008, AM J PHYSIOL-REG I, V294, pR539, DOI 10.1152/ajpregu.00628.2007
   Ochoa TJ, 2013, J PEDIATR-US, V162, P349, DOI 10.1016/j.jpeds.2012.07.043
   Ojeda NB, 2008, HYPERTENSION, V52, P44, DOI 10.1161/HYPERTENSIONAHA.107.092890
   Ojeda NB, 2012, HYPERTENSION, V60, P114, DOI 10.1161/HYPERTENSIONAHA.112.192955
   Oliveira AC, 2015, LIFE SCI, V136, P151, DOI 10.1016/j.lfs.2015.06.024
   Oliveira FS, 2025, BIOL RES NURS, V27, P142, DOI 10.1177/10998004241263100
   Padilha M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041081
   Padmanabhan V, 2016, ENDOCRINOLOGY, V157, P1328, DOI 10.1210/en.2016-1003
   Pandey KR, 2015, J FOOD SCI TECH MYS, V52, P7577, DOI 10.1007/s13197-015-1921-1
   Parra-Vargas M, 2023, MOL METAB, V71, DOI 10.1016/j.molmet.2023.101707
   Passos MARF, 2011, HORM METAB RES, V43, P636, DOI 10.1055/s-0031-1283192
   Paul HA, 2019, FASEB J, V33, P5153, DOI 10.1096/fj.201801551R
   Perrine CG, 2010, PEDIATRICS, V125, P627, DOI 10.1542/peds.2009-2571
   Nguyen PTH, 2019, ASIA-PAC J PUBLIC HE, V31, P183, DOI 10.1177/1010539519833497
   Pico C, 2022, NUTRIENTS, V14, DOI 10.3390/nu14010114
   Picó C, 2021, EUR J CLIN INVEST, V51, DOI 10.1111/eci.13482
   Plagemann A, 2012, BEST PRACT RES CL EN, V26, P641, DOI 10.1016/j.beem.2012.03.008
   Pluznick JL, 2017, CURR HYPERTENS REP, V19, DOI 10.1007/s11906-017-0722-5
   Powe CE, 2010, AM J HUM BIOL, V22, P50, DOI 10.1002/ajhb.20941
   Quin C, 2020, J BIOL CHEM, V295, P4035, DOI 10.1074/jbc.RA119.011351
   Quinn R, 2005, NUTRITION, V21, P775, DOI 10.1016/j.nut.2005.04.002
   Rajagopal G, 2019, J APPL TOXICOL, V39, P751, DOI 10.1002/jat.3764
   Ríos J, 2022, CRIT REV FOOD SCI, V62, P6821, DOI 10.1080/10408398.2021.1906627
   Ronco C, 2018, ADV CHRONIC KIDNEY D, V25, P382, DOI 10.1053/j.ackd.2018.08.004
   Ross MG, 2024, CHILDREN-BASEL, V11, DOI 10.3390/children11020141
   Rowe H, 2015, CHILD ADOL PSYCH CL, V24, P1, DOI 10.1016/j.chc.2014.09.005
   Rubio M, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0193527
   Saad AF, 2016, AM J OBSTET GYNECOL, V215, DOI 10.1016/j.ajog.2016.03.038
   Saarela T, 2005, ACTA PAEDIATR, V94, P1176, DOI 10.1080/08035250510036499
   Saben JL, 2020, AM J CLIN NUTR, V112, P1228, DOI 10.1093/ajcn/nqaa216
   Sánchez-Blanco C, 2019, FOOD CHEM TOXICOL, V123, P546, DOI 10.1016/j.fct.2018.12.006
   Sánchez-Garrido MA, 2013, ENDOCRINOLOGY, V154, P3387, DOI 10.1210/en.2012-2157
   Sandman CA, 2013, J PSYCHOSOM RES, V75, P327, DOI 10.1016/j.jpsychores.2013.07.009
   Sarkar A, 2021, J CLIN MED, V10, DOI 10.3390/jcm10030459
   Saxon DR, 2020, J CLIN ENDOCR METAB, V105, P2095, DOI 10.1210/clinem/dgaa261
   Schwarzenberg SJ, 2018, PEDIATRICS, V141, DOI 10.1542/peds.2017-3716
   Scurt FG, 2024, OBES REV, V25, DOI 10.1111/obr.13649
   Sebastian SA, 2024, CURR PROB CARDIOLOGY, V49, DOI 10.1016/j.cpcardiol.2023.102344
   Sheen JM, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-24010-0
   Shini VS, 2022, FOOD FUNCT, V13, P11954, DOI [10.1039/d2fo02371g, 10.1039/D2FO02371G]
   Shoji H, 2007, CURR OPIN CLIN NUTR, V10, P324, DOI 10.1097/MCO.0b013e3280a94f6d
   Silvestre-Roig C, 2020, NAT REV CARDIOL, V17, P327, DOI 10.1038/s41569-019-0326-7
   Singh M, 2020, ADV CHRONIC KIDNEY D, V27, P516, DOI 10.1053/j.ackd.2020.05.007
   Sirasanagandla SR, 2022, CURR MED CHEM, V29, P4235, DOI 10.2174/0929867328666211206111835
   Slabiak-Blaz N, 2015, KIDNEY BLOOD PRESS R, V40, P413, DOI 10.1159/000368515
   SNEED SM, 1981, AM J CLIN NUTR, V34, P1338, DOI 10.1093/ajcn/34.7.1338
   Song BJ, 2013, NUTRITION, V29, P195, DOI 10.1016/j.nut.2012.07.015
   Soraya H, 2022, IRAN J MED SCI, V47, P468, DOI 10.30476/IJMS.2021.91047.2205
   Souza LL, 2022, NUTRIENTS, V14, DOI 10.3390/nu14102045
   Spevacek AR, 2015, J NUTR, V145, P1698, DOI 10.3945/jn.115.210252
   Stahl A, 2014, NEONATOLOGY, V106, P254, DOI 10.1159/000365132
   Sun WX, 2023, SCI REP-UK, V13, DOI 10.1038/s41598-023-31690-w
   Tain YL, 2014, FREE RADICAL RES, V48, P580, DOI 10.3109/10715762.2014.895341
   Tain YL, 2025, BIOMEDICINES, V13, DOI 10.3390/biomedicines13020452
   Tain YL, 2025, PEDIATR NEONATOL, V66, pS18, DOI 10.1016/j.pedneo.2024.10.006
   Tain YL, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25189788
   Tain YL, 2024, NUTRIENTS, V16, DOI 10.3390/nu16183168
   Tain YL, 2024, NUTRIENTS, V16, DOI 10.3390/nu16162607
   Tain YL, 2024, NUTRIENTS, V16, DOI 10.3390/nu16091263
   Tain YL, 2024, ANTIOXIDANTS-BASEL, V13, DOI 10.3390/antiox13020226
   Tain YL, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12122059
   Tain YL, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12081629
   Tain YL, 2023, NUTRIENTS, V15, DOI 10.3390/nu15030697
   Tain YL, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040357
   Tain YL, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17010023
   Tain YL, 2014, INT J MOL SCI, V15, P18484, DOI 10.3390/ijms151018484
   Tain YL, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/283180
   Tain YL, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055420
   Tain YL, 2010, NITRIC OXIDE-BIOL CH, V23, P34, DOI 10.1016/j.niox.2010.03.005
   Talabi MB, 2020, CURR OPIN RHEUMATOL, V32, P238, DOI 10.1097/BOR.0000000000000710
   Tavares GA, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24010191
   Thaeomor A, 2019, ADV EXP MED BIOL, V1155, P415, DOI 10.1007/978-981-13-8023-5_39
   Thaeomor A, 2017, ADV EXP MED BIOL, V975, P295, DOI 10.1007/978-94-024-1079-2_26
   Tiao MM, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/942172
   Truchet S, 2017, BEST PRACT RES CL EN, V31, P367, DOI 10.1016/j.beem.2017.10.008
   Tsai CC, 2019, LIPIDS HEALTH DIS, V18, DOI 10.1186/s12944-019-0963-1
   Tsai TA, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17082780
   Vahdaninia M, 2019, EUR J NUTR, V58, P2597, DOI 10.1007/s00394-018-1824-9
   Verduci E, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020486
   Verduci E, 2014, NUTRIENTS, V6, P1711, DOI 10.3390/nu6041711
   VINA J, 1981, FEBS LETT, V126, P250, DOI 10.1016/0014-5793(81)80253-0
   Vogel HJ, 2012, BIOCHEM CELL BIOL, V90, P233, DOI [10.1139/O2012-016, 10.1139/o2012-016]
   Walton SL, 2018, PHARMACOL RES, V134, P320, DOI 10.1016/j.phrs.2018.06.001
   Wei ZZ, 2012, TOXICOL LETT, V212, P212, DOI 10.1016/j.toxlet.2012.05.023
   White B, 2009, AM FAM PHYSICIAN, V80, P345
   Witkowski M, 2020, CIRC RES, V127, P553, DOI 10.1161/CIRCRESAHA.120.316242
   Wlodek ME, 2008, KIDNEY INT, V74, P187, DOI 10.1038/ki.2008.153
   Wu ZH, 2014, EUR J NUTR, V53, P1669, DOI 10.1007/s00394-014-0673-4
   Xi ML, 2024, FRONT MICROBIOL, V15, DOI 10.3389/fmicb.2024.1356462
   Xiao DL, 2015, BIOL REPROD, V93, DOI 10.1095/biolreprod.115.132381
   Xiao DL, 2011, BRIT J PHARMACOL, V164, P1400, DOI 10.1111/j.1476-5381.2011.01437.x
   Xue QY, 2023, CELL CYCLE, V22, P1675, DOI 10.1080/15384101.2023.2225939
   Yang T, 2018, NAT REV NEPHROL, V14, P442, DOI 10.1038/s41581-018-0018-2
   Zamanillo R, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112589
   Zempleni J, 2017, GENES NUTR, V12, DOI 10.1186/s12263-017-0562-6
   Zeng B, 2021, ADV NUTR, V12, P1006, DOI 10.1093/advances/nmaa124
   Zhang ZY, 2013, NUTRIENTS, V5, P4800, DOI 10.3390/nu5124800
   Zheng HJ, 2021, CRIT REV FOOD SCI, V61, P577, DOI 10.1080/10408398.2020.1740645
   Zixin Y, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.929262
   Zólkiewicz J, 2020, NUTRIENTS, V12, DOI 10.3390/nu12082189
NR 222
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR 12
PY 2025
VL 17
IS 6
AR 995
DI 10.3390/nu17060995
PG 23
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 0OU5Q
UT WOS:001452453500001
PM 40290039
OA gold
DA 2025-06-11
ER

PT J
AU Dunham-Snary, KJ
   Sandel, MW
   Westbrook, DG
   Ballinger, SW
AF Dunham-Snary, Kimberly J.
   Sandel, Michael W.
   Westbrook, David G.
   Ballinger, Scott W.
TI A method for assessing mitochondrial bioenergetics in whole white
   adipose tissues
SO REDOX BIOLOGY
LA English
DT Article
DE Mitochondrion; White adipose tissue; Bioenergetics
ID METABOLIC SYNDROME; ENDOCRINE ORGAN; CARDIOVASCULAR-DISEASE; OXIDATIVE
   STRESS; DAMAGE; OBESITY; RESPIRATION; DYSFUNCTION; ADIPOCYTES; DNA
AB Obesity is a primary risk factor for numerous metabolic diseases including metabolic syndrome, type II diabetes (T2DM), cardiovascular disease and cancer. Although classically viewed as a storage organ, the field of white adipose tissue biology is expanding to include the consideration of the tissue as an endocrine organ and major contributor to overall metabolism. Given its role in energy production, the mitochondrion has long been a focus of study in metabolic dysfunction and a link between the organelle and white adipose tissue function is likely. Herein, we present a novel method for assessing mitochondrial bioenergetics from whole white adipose tissue. This method requires minimal manipulation of tissue, and eliminates the need for cell isolation and culture. Additionally, this method overcomes some of the limitations to working with transformed and / or isolated primary cells and allows for results to be obtained more expediently. In addition to the novel method, we present a comprehensive statistical analysis of bioenergetic data as well as guidelines for outlier analysis. (C) 2014 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-SA license
C1 [Dunham-Snary, Kimberly J.; Westbrook, David G.; Ballinger, Scott W.] Univ Alabama Birmingham, Dept Pathol, Div Mol & Cellular Pathol, Birmingham, AL 35294 USA.
   [Sandel, Michael W.] Univ Alabama Birmingham, Dept Biostat, Sect Stat Genet, Birmingham, AL 35294 USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham
RP Ballinger, SW (corresponding author), Univ Alabama Birmingham, Dept Pathol, Div Mol & Cellular Pathol, BMR2 530,1720 2nd Ave South, Birmingham, AL 35294 USA.
EM sballing@uab.edu
RI Dunham-Snary, Kimberly/O-4702-2018; Sandel, Michael/AAZ-2000-2020
OI Dunham-Snary, Kimberly/0000-0001-9760-342X; Sandel,
   Michael/0000-0001-9083-9202
FU NIH [HL94518, HL103859]; American Heart Association Predoctoral
   Fellowship [11PRE7650033]; NHLBI Post-Doctoral Training Grant
   [5T32HL072757]; American Heart Association (AHA) [11PRE7650033] Funding
   Source: American Heart Association (AHA)
FX This study was funded by NIH grants HL94518 (S.W.B.) and HL103859
   (S.W.B.), an American Heart Association Predoctoral Fellowship
   11PRE7650033 (K.J.D.) and NHLBI Post-Doctoral Training Grant
   5T32HL072757 (M.W.S.). The authors thank Dr. Doug Moellering and theUAB
   Diabetes Research Center Bioanalytical Redox Biology Core (P60
   DK079626).
CR Ahima RS, 2006, OBESITY, V14, P242, DOI 10.1038/oby.2006.317
   [Anonymous], 2009, National health statistics reports
   Arner P, 2010, BIOCHEM BIOPH RES CO, V396, P101, DOI 10.1016/j.bbrc.2010.02.165
   Aroor AR, 2012, CARDIORENAL MED, V2, P87, DOI 10.1159/000335675
   Ballinger SW, 2005, FREE RADICAL BIO MED, V38, P1278, DOI 10.1016/j.freeradbiomed.2005.02.014
   BJORNTORP P, 1971, ACTA MED SCAND, V190, P363
   Choo HJ, 2006, DIABETOLOGIA, V49, P784, DOI 10.1007/s00125-006-0170-2
   Curtis JM, 2012, J BIOL CHEM, V287, P32967, DOI 10.1074/jbc.M112.400663
   Dranka BP, 2010, FREE RADICAL BIO MED, V48, P905, DOI 10.1016/j.freeradbiomed.2010.01.015
   Galloway CA, 2013, ANTIOXID REDOX SIGN, V19, P415, DOI 10.1089/ars.2012.4779
   Gerencser AA, 2009, ANAL CHEM, V81, P6868, DOI 10.1021/ac900881z
   James AM, 2002, J BIOMED SCI, V9, P475, DOI 10.1159/000064721
   Jenks G., 1967, Int Yearb Cartogr
   Jiang B, 2013, PROF GEOGR, V65, P482, DOI 10.1080/00330124.2012.700499
   Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2548, DOI 10.1210/jc.2004-0395
   Kuzawa CW, 1998, YEARB PHYS ANTHROPOL, V41, P177
   Medina-Gómez G, 2012, BEST PRACT RES CL EN, V26, P791, DOI 10.1016/j.beem.2012.06.002
   Mercer JR, 2010, CIRC RES, V107, P1021, DOI 10.1161/CIRCRESAHA.110.218966
   Mohamed-Ali V, 1998, INT J OBESITY, V22, P1145, DOI 10.1038/sj.ijo.0800770
   Mounier R, 2013, CELL METAB, V18, P251, DOI 10.1016/j.cmet.2013.06.017
   Roger VL, 2011, CIRCULATION, V123, pE18, DOI 10.1161/CIR.0b013e3182009701
   Sansbury BE, 2012, CIRC RES, V111, P1176, DOI [10.1161/CIRCRESAHA.112.266395, 10.1161/circresaha.112.266395]
   Schuh RA, 2014, BMC NEUROSCI, V15, DOI 10.1186/1471-2202-15-24
   Sellayah D, 2011, CELL METAB, V14, P478, DOI 10.1016/j.cmet.2011.08.010
   Strissel KJ, 2007, DIABETES, V56, P2910, DOI 10.2337/db07-0767
   Wang T, 2010, OBESITY, V18, P1493, DOI 10.1038/oby.2009.456
   Wang YC, 2011, LANCET, V378, P815, DOI 10.1016/S0140-6736(11)60814-3
   Wei YH, 1998, ANN NY ACAD SCI, V854, P155, DOI 10.1111/j.1749-6632.1998.tb09899.x
   Westbrook DG, 2010, CARDIOVASC TOXICOL, V10, P216, DOI 10.1007/s12012-010-9085-8
   Wilson PWF, 2005, CIRCULATION, V112, P3066, DOI 10.1161/CIRCULATIONAHA.105.539528
   Wozniak SE, 2009, DIGEST DIS SCI, V54, P1847, DOI 10.1007/s10620-008-0585-3
   Yehuda-Shnaidman E, 2010, DIABETES, V59, P2474, DOI 10.2337/db10-0245
NR 32
TC 31
Z9 34
U1 0
U2 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PY 2014
VL 2
BP 656
EP 660
DI 10.1016/j.redox.2014.04.005
PG 5
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CD0MY
UT WOS:000350769600076
PM 24936439
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Min, BK
   Kang, HJ
   Choi, BJ
   Jeon, YH
   Cho, JY
   Lee, IK
   Kim, DW
AF Min, Byong-Keol
   Kang, Hyeon-Ji
   Choi, Byung-Jun
   Jeon, Yong Hyun
   Cho, Je-Yoel
   Lee, In-Kyu
   Kim, Dong Wook
TI Phenylbutyrate Ameliorates High-Fat Diet-Induced Obesity via Brown
   Adipose Tissue Activation
SO BIOLOGICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE phenylbutyrate; liver type phosphofructokinase; obesity; uncoupling
   protein 1; brown adipose tissue
ID 4-PHENYLBUTYRATE PROTECTS; SODIUM PHENYLBUTYRATE; STRESS; EXPRESSION;
   THERMOGENESIS; INHIBITION; REDUCTION; GENE
AB Obesity, which is characterized by an excessive accumulation of body fat, is one of the critical factors causing metabolic syndrome. Many studies have been performed to identify appropriate agents to control obesity, but toxicity remains a problem. Herein, we identified that phenylbutyrate (PBA), which has been used to treat urea cycle disorder with very low toxicity for a long time, efficiently inhibited high fat-induced body weight gain in a diet-induced obesity mouse model (DIO model). PBA treatment decreased body fat mass and increased lean composition. Moreover, PBA increased brown adipose tissue (BAT) activity by increasing glucose uptake, thereby improving glucose tolerance and insulin tolerance. Interestingly, PBA could induce the expression of liver type phosphofructokinase (PFKL), a key enzyme in the glycolytic pathway, and knocking down PFKL dramatically repressed the expression level of Uep1 as well as those of Prdm16, Cidea, Pgc1 alpha, and Ppar gamma, which are marker genes for BAT activation. These results strongly suggested that PBA could increase energy expenditure by increasing BAT activity via the induction of PFKL. Taken together, PBA could be used as a therapeutic agent for people with obesity to prevent the development of metabolic syndrome.
C1 [Min, Byong-Keol; Kang, Hyeon-Ji; Lee, In-Kyu] Kyungpook Natl Univ, Res Inst Aging & Metab, 80 Daehak Ro, Daegu 41566, South Korea.
   [Choi, Byung-Jun] Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, 80 Daehak Ro, Daegu 41566, South Korea.
   [Jeon, Yong Hyun] Daegu Gyeongbuk Med Innovat Fdn, Lab Anim Ctr, 88 Dongnae Ro, Daegu 41061, South Korea.
   [Cho, Je-Yoel; Kim, Dong Wook] Seoul Natl Univ, Coll Vet Med, Dept Biochem, 1 Gwanak Ro, Seoul 08826, South Korea.
   [Lee, In-Kyu] Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, 130 Dongdeok Ro, Daegu 41944, South Korea.
   [Lee, In-Kyu; Kim, Dong Wook] Kyungpook Natl Univ Hosp, Leading Edge Res Ctr Drug Discovery & Dev Diabet, 807 Hoguk Ro, Daegu 41404, South Korea.
C3 Kyungpook National University (KNU); Kyungpook National University
   (KNU); Seoul National University (SNU); Kyungpook National University
   (KNU); Kyungpook National University Hospital (KNUH); Kyungpook National
   University (KNU); Kyungpook National University Hospital (KNUH)
RP Lee, IK (corresponding author), Kyungpook Natl Univ, Res Inst Aging & Metab, 80 Daehak Ro, Daegu 41566, South Korea.; Kim, DW (corresponding author), Seoul Natl Univ, Coll Vet Med, Dept Biochem, 1 Gwanak Ro, Seoul 08826, South Korea.; Lee, IK (corresponding author), Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, 130 Dongdeok Ro, Daegu 41944, South Korea.; Lee, IK; Kim, DW (corresponding author), Kyungpook Natl Univ Hosp, Leading Edge Res Ctr Drug Discovery & Dev Diabet, 807 Hoguk Ro, Daegu 41404, South Korea.
EM leei@knu.ac.kr; bellocan@snu.ac.kr
RI Jeon, Yong/N-6910-2019; Lee, In-Kyu/AAR-6374-2021
OI Min, Byong-Keol/0000-0002-8454-8940
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF) - Ministry of Education [NRF-2014R1A1A2055894,
   2017R1D1A1B03030844, 2017R1D1A1B03028340]; Korea Health Technology R&D
   Project through the Korea Health Industry Development Institute (KHIDI)
   - Ministry of Health & Welfare, Republic of Korea [HI16C1501]; National
   Research Foundation (NRF) - Ministry of Science, ICT & Future Planning
   [2016M3A9B6026771, 2014M3A9D5A01073598]
FX This work was supported by the Basic Science Research Program through
   the National Research Foundation of Korea (NRF) funded by the Ministry
   of Education (NRF-2014R1A1A2055894, 2017R1D1A1B03030844, and
   2017R1D1A1B03028340), by a Grant from the Korea Health Technology R&D
   Project through the Korea Health Industry Development Institute (KHIDI),
   funded by the Ministry of Health & Welfare, Republic of Korea. (Grant
   Number: HI16C1501), and by the National Research Foundation (NRF) funded
   by the Ministry of Science, ICT & Future Planning (2016M3A9B6026771,
   2014M3A9D5A01073598).
CR Altintas MM, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-198
   Bar-Ner M, 1999, CLIN CANCER RES, V5, P1509
   Basseri S, 2009, J LIPID RES, V50, P2486, DOI 10.1194/jlr.M900216-JLR200
   DOVER GJ, 1994, BLOOD, V84, P339
   Feldmann HM, 2009, CELL METAB, V9, P203, DOI 10.1016/j.cmet.2008.12.014
   Gilbert J, 2001, CLIN CANCER RES, V7, P2292
   Gore SD, 2000, EXPERT OPIN INV DRUG, V9, P2923, DOI 10.1517/13543784.9.12.2923
   Kawasaki N, 2012, SCI REP-UK, V2, DOI 10.1038/srep00799
   Kopecky J, 1995, J CLIN INVEST, V96, P2914, DOI 10.1172/JCI118363
   Kopecky J, 1996, AM J PHYSIOL-ENDOC M, V270, pE768, DOI 10.1152/ajpendo.1996.270.5.E768
   Kopecky J, 1996, AM J PHYSIOL-ENDOC M, V270, pE776, DOI 10.1152/ajpendo.1996.270.5.E776
   Li FF, 2016, J BIOL CHEM, V291, P4523, DOI 10.1074/jbc.M115.677930
   Liu SH, 2016, ONCOTARGET, V7, P22116, DOI 10.18632/oncotarget.7904
   Lowell BB, 2000, NATURE, V404, P652, DOI 10.1038/35007527
   Mercuri E, 2004, NEUROMUSCULAR DISORD, V14, P130, DOI 10.1016/j.nmd.2003.11.006
   Min BK, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.00944
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Oh CM, 2015, NAT COMMUN, V6, DOI 10.1038/ncomms7794
   Ohno H, 2013, NATURE, V504, P163, DOI 10.1038/nature12652
   Ren LP, 2013, INT J MOL MED, V32, P1029, DOI 10.3892/ijmm.2013.1493
   Rubenstein RC, 2001, AM J PHYSIOL-LUNG C, V281, pL43, DOI 10.1152/ajplung.2001.281.1.L43
   Saito M, 2013, OBES RES CLIN PRACT, V7, pE432, DOI 10.1016/j.orcp.2013.09.001
   Uldry M, 2006, CELL METAB, V3, P333, DOI 10.1016/j.cmet.2006.04.002
   Vilatoba M, 2005, SURGERY, V138, P342, DOI 10.1016/j.surg.2005.04.019
NR 24
TC 9
Z9 12
U1 0
U2 5
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0918-6158
J9 BIOL PHARM BULL
JI Biol. Pharm. Bull.
PD SEP
PY 2019
VL 42
IS 9
BP 1554
EP 1561
DI 10.1248/bpb.b19-00346
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IV2KW
UT WOS:000484107100016
PM 31474715
OA gold
DA 2025-06-11
ER

PT J
AU Bezek, S
   Ujházy, E
   Dubovicky, M
   Mach, M
AF Bezek, Stefan
   Ujhazy, Eduard
   Dubovicky, Michal
   Mach, Mojmir
TI Nongenomic memory of foetal history in chronic diseases development
SO NEUROENDOCRINOLOGY LETTERS
LA English
DT Review
DE fetal programming; chronic diseases; epigenetic; molecular and endocrine
   mechanisms; hypoxia
ID METABOLIC SYNDROME; LIFE-HISTORY; EVOLUTIONARY PERSPECTIVE;
   POSTNATAL-DEVELOPMENT; GROWTH-RETARDATION; ENDOCRINE PANCREAS; OXIDATIVE
   STRESS; ADULT DISEASES; LUNG-FUNCTION; EARLY ORIGINS
AB Foetal growth from conception to birth is a complex process predetermined by the genetic configuration of the foetus, the availability of nutrients and oxygen to the foetus, maternal nutrition and various growth factors and hormones of maternal, foetal and placental origin.
   Maintenance of the optimal foetal environment is the key factor of the future quality of life. Such conditions like inadequate nutrition and oxygen supply, infection, hypertension, gestational diabetes or drug abuse by the mother, expose the foetus to nonphysiological environment. In conditions of severe intrauterine deprivation, there is a potential loss of structural units within the developing organ systems affecting their functionality and efficiency. Extensive human epidemiologic and animal model data indicate that during critical periods of prenatal and postnatal mammalian development, nutrition and other environmental stimuli influence developmental pathways and thereby induce permanent changes in metabolism and chronic disease susceptibility.
   The studies reviewed in this article show how environmental factors influence a diverse array of molecular mechanisms and consequently alter disease risk including diseases such as metabolic syndrome and cardiovascular diseases, insulin resistance and diabetes mellitus, neuropsychiatric disorders, osteoporosis, asthma and immune system diseases.
C1 [Bezek, Stefan] Slovak Acad Sci, Inst Expt Pharmacol, Lab Cell Cultures, Bratislava 84104, Slovakia.
C3 Slovak Academy of Sciences
RP Bezek, S (corresponding author), Slovak Acad Sci, Inst Expt Pharmacol, Lab Cell Cultures, Dubravska Cesta 9, Bratislava 84104, Slovakia.
EM stefan.bezek@savba.sk
RI , Mojino/GXZ-5248-2022
OI Dubovicky, Michal/0009-0001-5631-918X; Mach, Mojmir/0000-0001-6958-1024
CR Amann K, 2004, PEDIATR NEPHROL, V19, P1319, DOI 10.1007/s00467-004-1643-5
   Barker DJP, 1998, CLIN SCI, V95, P115, DOI 10.1042/CS19980019
   Bellingham-Young D, 2002, NEUROENDOCRINOL LETT, V23, P219
   Bellingham-Young DA, 2003, NEUROENDOCRINOL LETT, V24, P412
   Béringue F, 2002, DIABETES, V51, P385, DOI 10.2337/diabetes.51.2.385
   Boksa P, 2008, J PSYCHIATR NEUROSCI, V33, P183
   Cooper C, 2006, OSTEOPOROSIS INT, V17, P337, DOI 10.1007/s00198-005-2039-5
   Edwards CA, 2003, THORAX, V58, P1061, DOI 10.1136/thorax.58.12.1061
   Edwards CJ, 2006, CLIN EXP IMMUNOL, V143, P1, DOI 10.1111/j.1365-2249.2005.02940.x
   Foltinová J, 2007, NEUROENDOCRINOL LETT, V28, P335
   Forsyth JS, 2004, ARCH DIS CHILD-FETAL, V89, pF442, DOI 10.1136/adc.2003.027896
   Fowden AL, 2004, REPRODUCTION, V127, P515, DOI 10.1530/rep.1.00033
   Gicquel C, 2006, HORM RES, V65, P28, DOI 10.1159/000091503
   Gluckman PD, 2007, J INTERN MED, V261, P461, DOI 10.1111/j.1365-2796.2007.01802.x
   Gluckman PD, 2005, TRENDS ECOL EVOL, V20, P527, DOI 10.1016/j.tree.2005.08.001
   Gluckman PD, 2004, PEDIATR RES, V56, P311, DOI 10.1203/01.PDR.0000135998.08025.FB
   Gluckman PD, 2004, SCIENCE, V305, P1733, DOI 10.1126/science.1095292
   Gluckman PD, 2007, AM J HUM BIOL, V19, P1, DOI 10.1002/ajhb.20590
   Greenough A, 2004, EUR RESPIR J, V24, P731, DOI 10.1183/09031936.04.00060304
   Guron G, 2000, J HYPERTENS, V18, P123, DOI 10.1097/00004872-200018020-00001
   Hales CN, 2003, DIABETOLOGIA, V46, P1013, DOI 10.1007/s00125-003-1131-7
   Hill DJ, 2005, REV ENDOCR METAB DIS, V6, P229, DOI 10.1007/s11154-005-3054-8
   Hoo AF, 2004, AM J RESP CRIT CARE, V170, P527, DOI 10.1164/rccm.200311-1552OC
   Huang STJ, 2004, FASEB J, V18, P1348, DOI 10.1096/fj.03-1377com
   Javaid MK, 2002, BEST PRACT RES CL EN, V16, P349, DOI 10.1053/beem.2002.0199
   Junien C, 2005, M S-MED SCI, V21, P44
   Landgraf MAV, 2005, J NUTR, V135, P1480, DOI 10.1093/jn/135.6.1480
   Langley-Evans S. C., 2003, Archives of Physiology and Biochemistry, V111, P8, DOI 10.1076/apab.111.1.8.15136
   Langley-Evans SC, 2001, P NUTR SOC, V60, P505, DOI 10.1079/PNS2001111
   Lanham SA, 2008, OSTEOPOROSIS INT, V19, P147, DOI 10.1007/s00198-007-0443-8
   Lanham SA, 2008, OSTEOPOROSIS INT, V19, P157, DOI 10.1007/s00198-007-0448-3
   LAU C, 2004, DEFECTS RES C, V72, P300
   Lau Christopher, 2004, Birth Defects Res C Embryo Today, V72, P300, DOI 10.1002/bdrc.20029
   Li GH, 2003, J SOC GYNECOL INVEST, V10, P265, DOI 10.1016/S1071-5576(03)00074-1
   LUCAS A, 1992, EARLY DIET LATER CON, P24
   Lumbers ER, 2001, CLIN EXP PHARMACOL P, V28, P942, DOI 10.1046/j.1440-1681.2001.03554.x
   Mach M, 2006, NEUROENDOCRINOL LETT, V27, P69
   Matthews SG, 2002, TRENDS ENDOCRIN MET, V13, P373, DOI 10.1016/S1043-2760(02)00690-2
   McDade TW, 2005, AM J HUM BIOL, V17, P81, DOI 10.1002/ajhb.20095
   McMillen IC, 2005, PHYSIOL REV, V85, P571, DOI 10.1152/physrev.00053.2003
   MCMULLEN M, 2005, AM J PHYSIOL-REG I, V288, pR5
   Mehta G, 2002, CALCIFIED TISSUE INT, V71, P493, DOI 10.1007/s00223-001-2104-9
   Nathanielsz PW, 2006, ILAR J, V47, P73, DOI 10.1093/ilar.47.1.73
   Phillips DIW, 2006, J PHYSIOL-LONDON, V572, P45, DOI 10.1113/jphysiol.2005.104695
   Plagemann A, 2005, PHYSIOL BEHAV, V86, P661, DOI 10.1016/j.physbeh.2005.08.065
   SCHMIDTKASTNER R, 2005, MOL PSYCHIATR, V200, P434
   Simmons R, 2006, ENDOCRIN METAB CLIN, V35, P193, DOI 10.1016/j.ecl.2005.09.006
   Simmons RA, 2006, FREE RADICAL BIO MED, V40, P917, DOI 10.1016/j.freeradbiomed.2005.12.018
   Simmons RA, 2001, DIABETES, V50, P2279, DOI 10.2337/diabetes.50.10.2279
   Simmons RA, 2007, REV ENDOCR METAB DIS, V8, P95, DOI 10.1007/s11154-007-9045-1
   Tang WY, 2007, REV ENDOCR METAB DIS, V8, P173, DOI 10.1007/s11154-007-9042-4
   Tantisira KG, 2001, THORAX, V56, P64
   WALKER M, 2006, MED HYPOTHESES, V66, P38
   Wang Lei, 2007, Birth Defects Research, V81, P144, DOI 10.1002/bdrc.20097
   Worthman CM, 2005, AM J HUM BIOL, V17, P95, DOI 10.1002/ajhb.20096
   Wu GY, 2004, J NUTR, V134, P2169, DOI 10.1093/jn/134.9.2169
   Zandi-Nejad K, 2006, HYPERTENSION, V47, P502, DOI 10.1161/01.HYP.0000198544.09909.1a
   Zhang LB, 2005, J SOC GYNECOL INVEST, V12, P2, DOI 10.1016/j.jsgi.2004.09.004
   Zornberg GL, 2000, AM J PSYCHIAT, V157, P196, DOI 10.1176/appi.ajp.157.2.196
NR 59
TC 7
Z9 8
U1 0
U2 7
PU MAGHIRA & MAAS PUBLICATIONS
PI STOCKHOLM
PA PO BOX 26132, S-100 41 STOCKHOLM, SWEDEN
SN 0172-780X
J9 NEUROENDOCRINOL LETT
JI Neuroendocrinol. Lett.
PD OCT
PY 2008
VL 29
IS 5
BP 620
EP 626
PG 7
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 381RI
UT WOS:000261553200004
PM 18987584
DA 2025-06-11
ER

PT J
AU Sovová, E
   Vrbková, J
   Stejskal, D
   Kamínek, M
   Metelková, I
   Budikova, M
   Kaletová, M
   Sova, M
   Sovová, M
AF Sovova, E.
   Vrbkova, J.
   Stejskal, D.
   Kaminek, M.
   Metelkova, I.
   Budikova, M.
   Kaletova, M.
   Sova, M.
   Sovova, M.
TI Pilot study of A-FABP levels as a predictive factor of SPECT results in
   asymptomatic relatives of patients with cardiovascular disease
SO BIOMARKERS IN MEDICINE
LA English
DT Article
DE A-FABP; cardiovascular prevention; first-degree relatives; stress-gated
   SPECT prediction
ID ACID-BINDING PROTEIN; CORONARY-ARTERY-DISEASE; COMPUTED-TOMOGRAPHY;
   RISK-FACTORS; METABOLIC SYNDROME; HEART-DISEASE; CALCIUM; ASSOCIATION;
   INDIVIDUALS; AP2
AB Background: A-FABP is a promising link between metabolic syndrome and atherosclerosis. It is not well known whether level of A-FABP predicts results of SPECT. Patients & methods: In 82 subjects (53 males) with a median age of 54 years, who were first-degree relatives of patients with cardiovascular disease, the following tests and examinations were performed: A-FABP, calcium score (CS) and SPECT. Results: Subjects with positive and negative SPECT results differed significantly in the noncategorized CS (p = 0.001), uric acid (p = 0.025) and the total cholesterol: high-density lipoprotein ratio (p = 0.043), but not in other parameters (including A-FABP). To predict SPECT results, the best model proved to be a logistic regression model with gender and noncategorized CS as predictors, with an area under the receiver operating characteristic curve of 0.89 (the sensitivity and specificity based on a CS cutoff of 11.1 were 77.78 and 75.34%, respectively). Conclusion: The serum level of A-FABP is not a predictor of a positive SPECT result.
C1 [Sovova, E.; Kaletova, M.] Palacky Univ, Fac Med & Dent, Dept Internal Med Cardiol 1, CR-77147 Olomouc, Czech Republic.
   [Sovova, E.; Kaminek, M.; Metelkova, I.; Budikova, M.; Kaletova, M.; Sova, M.] Univ Hosp Olomouc, Olomouc, Czech Republic.
   [Vrbkova, J.] Palacky Univ, Fac Sci, Dept Geoinformat, CR-77147 Olomouc, Czech Republic.
   [Stejskal, D.] Palacky Univ, Fac Med & Dent, Dept Med Chem & Biochem, CR-77147 Olomouc, Czech Republic.
   [Kaminek, M.; Metelkova, I.; Budikova, M.] Palacky Univ, Fac Med & Dent, Dept Nucl Med, CR-77147 Olomouc, Czech Republic.
   [Sova, M.] Palacky Univ, Fac Med & Dent, Dept Resp Med, CR-77147 Olomouc, Czech Republic.
   [Sovova, M.] Palacky Univ, Fac Med & Dent, CR-77147 Olomouc, Czech Republic.
C3 Palacky University Olomouc; University Hospital Olomouc; Palacky
   University Olomouc; Palacky University Olomouc; Palacky University
   Olomouc; Palacky University Olomouc; Palacky University Olomouc
RP Sova, M (corresponding author), Palacky Univ, Fac Med & Dent, Dept Resp Med, CR-77147 Olomouc, Czech Republic.
EM milan.sova@fnol.cz
RI Sova, Milan/AAH-3802-2020; Budíková, Marie/AAF-5455-2019; Stejskal,
   David/D-6125-2018
OI Stejskal, David/0000-0003-1204-0395
FU Operational Program Education for Competitiveness - European Social Fund
   of the Ministry of Education, Youth and Sports of the Czech Republic
   [CZ.1.07/2.3.00/20.0170]
FX The authors gratefully acknowledge the support by the Operational
   Program Education for Competitiveness - European Social Fund (project
   CZ.1.07/2.3.00/20.0170 of the Ministry of Education, Youth and Sports of
   the Czech Republic). The authors have no other relevant affiliations or
   financial involvement with any organization or entity with a financial
   interest in or financial conflict with the subject matter or materials
   discussed in the manuscript apart from those disclosed.
CR AGATSTON AS, 1990, J AM COLL CARDIOL, V15, P827, DOI 10.1016/0735-1097(90)90282-T
   Bagheri R, 2010, AM J CARDIOL, V106, P1118, DOI 10.1016/j.amjcard.2010.06.028
   Blumenthal RS, 2006, AM J CARDIOL, V97, P328, DOI 10.1016/j.amjcard.2005.08.048
   Chang SM, 2009, J AM COLL CARDIOL, V54, P1872, DOI 10.1016/j.jacc.2009.05.071
   De Backer G, 2012, EUROPEAN GUIDELINES
   Doi M, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-44
   Erbay Ebru, 2007, Curr Atheroscler Rep, V9, P222, DOI 10.1007/s11883-007-0023-6
   Hoff JA, 2003, ANN EPIDEMIOL, V13, P163, DOI 10.1016/S1047-2797(02)00277-6
   Hsu BG, 2010, CIRC J, V74, P327, DOI 10.1253/circj.CJ-09-0568
   Huang CL, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-105
   Karpisek M, 2007, EUR J CLIN INVEST, V37, P637, DOI 10.1111/j.1365-2362.2007.01835.x
   Khandaker MH, 2009, J NUCL CARDIOL, V16, P516, DOI 10.1007/s12350-009-9085-x
   Kral BG, 2011, EUR HEART J, V32, P2766, DOI 10.1093/eurheartj/ehr261
   Krusinová E, 2008, DIABETES RES CLIN PR, V82, pS127, DOI 10.1016/j.diabres.2008.09.023
   Makowski L, 2005, J BIOL CHEM, V280, P12888, DOI 10.1074/jbc.M413788200
   Makowski L, 2001, NAT MED, V7, P699, DOI 10.1038/89076
   Metelkova I, 2010, Vnitr Lek, V56, P1122
   Miyoshi T, 2010, ATHEROSCLEROSIS, V211, P164, DOI 10.1016/j.atherosclerosis.2010.01.032
   Peeters W, 2011, EUR HEART J, V32, P1758, DOI 10.1093/eurheartj/ehq387
   Perrone-Filardi P, 2011, EUR HEART J, V32, P1986, DOI 10.1093/eurheartj/ehq235
   Rhee EJ, 2009, EUR J ENDOCRINOL, V160, P165, DOI 10.1530/EJE-08-0665
   Rozanski A, 2011, J NUCL CARDIOL, V18, P291, DOI 10.1007/s12350-010-9324-1
   Shaw LJ, 2006, EUR HEART J, V27, P968, DOI 10.1093/eurheartj/ehi750
   Sovova E, 2013, Vnitr Lek, V59, P31
   Sovova E, 2014, CENT EUR J MED, V9, P28, DOI 10.2478/s11536-013-0231-0
   Storch J, 2008, ANNU REV NUTR, V28, P73, DOI 10.1146/annurev.nutr.27.061406.093710
   Taylor AJ, 2005, J AM COLL CARDIOL, V46, P807, DOI 10.1016/j.jacc.2005.05.049
   Tso AWK, 2007, DIABETES CARE, V30, P2667, DOI 10.2337/dc07-0413
   Tuncman G, 2006, P NATL ACAD SCI USA, V103, P6970, DOI 10.1073/pnas.0602178103
   Writing Committee Members; ACC/AHA Task Force Members, 2010, J AM COLL CARDIOL, V56, P2182
   Zellweger MJ, 2009, J NUCL CARDIOL, V16, P193, DOI 10.1007/s12350-008-9016-2
NR 31
TC 0
Z9 0
U1 0
U2 1
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1752-0363
EI 1752-0371
J9 BIOMARK MED
JI Biomark. Med.
PD JUN
PY 2014
VL 8
IS 5
BP 633
EP 640
DI 10.2217/BMM.13.160
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AO0QK
UT WOS:000341015700010
PM 25123032
DA 2025-06-11
ER

PT J
AU Armstrong, AW
   Zhao, Y
   Herrera, V
   Li, YF
   Bancroft, T
   Hull, M
   Altan, A
AF Armstrong, April W.
   Zhao, Yang
   Herrera, Vivian
   Li, Yunfeng
   Bancroft, Tim
   Hull, Michael
   Altan, Aylin
TI Drivers of Healthcare Costs Among the Costliest Patients With Psoriasis
   Over Three Years in a United States Health Plan
SO JOURNAL OF DRUGS IN DERMATOLOGY
LA English
DT Article
ID INCREASED PREVALENCE; ECONOMIC BURDEN; METABOLIC SYNDROME;
   DIABETES-MELLITUS; RISK; RECOMMENDATIONS; COMORBIDITIES; ASSOCIATION;
   DEPRESSION; MODERATE
AB Objective: To compare patients with psoriasis by cost level over 3 years.
   Methods: Psoriasis patients in a large US health plan in 2011-2013 were identified. Four groups were created by healthcare costs excluding biologics: patients having top 10% of costs in all 3 years (Top), top 10% in 2 of 3 years (High), bottom 90% in 2 of 3 years (Medium), and bottom 90% in all 3 years (Bottom). Comorbidities, utilization, and costs between groups were compared.
   Results: The study included 18,653 patients: 514 (3%), 805 (4%), 2,443 (13%), and 14,891 (80%) patients in the Top, High, Medium, and Bottom groups, respectively. Significantly more patients in the Top vs Bottom group had diabetes (31.1% vs 9.4%), cardiovascular disease (26.5% vs 4.3%), psoriatic arthritis (25.7% vs 10.7%), depression (27.8% vs 6.9%), and anxiety (22.0% vs 7.9%) in 2011 (all P<0.05). Patients in the Top group had more unique 2011 prescriptions (17.7 vs 6.6; P<0.001) than the Bottom group, but similar biologic use (22.4% vs 21.6%). Patients in the Top, High, Medium, and Bottom groups had mean 2011 total costs of $68,913, $40,575, $24,292, and $8,815, and contributed to 14%, 13%, 23%, and 51% of the overall costs, respectively. Mean total costs increased 14-18% over time for all groups. Although mean 2011 total costs for patients in the Top group were 78 times of those in the Bottom group, psoriasis-related costs were less disparate ($8,716 vs $4,541). Compared with patients in the Bottom group, those in the Top group were more likely to have any 2011 hospitalization (36.8% vs 2.6%; psoriasis-related: 11.1% vs 0.7%) or emergency visit (50.8% vs 20.8%; psoriasis-related: 3.9% vs 1.0%).
   Conclusion: The costliest patients with psoriasis had significantly higher prevalence of comorbidities, prescription fills, inpatient and emergency utilization, but not biologic medication use or biologic costs.
C1 [Armstrong, April W.] Univ Southern Calif, Los Angeles, CA USA.
   [Zhao, Yang; Herrera, Vivian; Li, Yunfeng] Novartis Pharmaceut, Hlth Econ & Outcomes Res, E Hanover, NJ USA.
   [Hull, Michael] Optum, Hlth Econ & Outcomes Res, Eden Prairie, MN 55344 USA.
   [Altan, Aylin] Optum Labs, Eden Prairie, MN USA.
C3 University of Southern California; Novartis; Novartis USA; Optum; Optum
RP Hull, M (corresponding author), Optum, Hlth Econ & Outcomes Res, Eden Prairie, MN 55344 USA.
EM michael.hull@optum.com
FU Novartis Pharmaceuticals Corporation (NPC)
FX This study was supported by Novartis Pharmaceuticals Corporation (NPC),
   Financial support was provided in the form of employment (Zhao, Li,
   Herrera); consultancies (Armstrong); and contract (Optum, Inc., by which
   authors Bancroft, Hull, and Altan, and medical writer C. Jennermann, are
   employed). Dr. Armstrong is employed by the University of Southern
   California, Los Angeles.
CR American Academy of Dermatology, 2015, CLIN GUID PSOR
   Armstrong AW, 2013, J AM ACAD DERMATOL, V68, P654, DOI 10.1016/j.jaad.2012.08.015
   Armstrong AW, 2013, J HYPERTENS, V31, P433, DOI 10.1097/HJH.0b013e32835bcce1
   Armstrong AW, 2013, JAMA DERMATOL, V149, P84, DOI 10.1001/2013.jamadermatol.406
   Armstrong EJ, 2014, J AM HEART ASSOC, V2
   Azfar RS, 2012, ARCH DERMATOL, V148, P995, DOI 10.1001/archdermatol.2012.1401
   Benson MM, 2015, CARDIOL REV, V23, P312, DOI 10.1097/CRD.0000000000000048
   Boehncke WH, 2015, LANCET, V386, P983, DOI 10.1016/S0140-6736(14)61909-7
   Brezinski EA, 2015, JAMA DERMATOL, V151, P651, DOI 10.1001/jamadermatol.2014.3593
   Cohen AD, 2007, ACTA DERM-VENEREOL, V87, P506, DOI 10.2340/00015555-0297
   Dommasch ED, 2015, BRIT J DERMATOL, V173, P975, DOI 10.1111/bjd.14032
   Feldman SR, 2015, J MANAG CARE SPEC PH, V21, P874, DOI 10.18553/jmcp.2015.21.10.874
   Gelfand JM, 2006, JAMA-J AM MED ASSOC, V296, P1735, DOI 10.1001/jama.296.14.1735
   Gleason PP, 2013, J MANAGE CARE PHARM, V19, P542, DOI 10.18553/jmcp.2013.19.7.542
   Han CL, 2011, J DRUGS DERMATOL, V10, P843
   Hjuler KF, 2015, AM J MED, V128, P1325, DOI 10.1016/j.amjmed.2015.05.041
   Iskandar I, 2015, BRIT J DERMATOL, V173, P510, DOI 10.1111/bjd.13908
   Jacobi A, 2015, DERMATOLOGY, V231, P231, DOI 10.1159/000433528
   Jensen P, 2016, ACTA DERM-VENEREOL, V96, P39, DOI 10.2340/00015555-2183
   Kimball AB, 2011, J EUR ACAD DERMATOL, V25, P157, DOI 10.1111/j.1468-3083.2010.03730.x
   Mustonen A, 2015, BMC HEALTH SERV RES, V15, DOI 10.1186/s12913-015-0752-0
   Neimann AL, 2006, J AM ACAD DERMATOL, V55, P829, DOI 10.1016/j.jaad.2006.08.040
   Norlin JM, 2015, ACTA DERM-VENEREOL, V95, P156, DOI 10.2340/00015555-1895
   Rachakonda TD, 2014, J AM ACAD DERMATOL, V70, P512, DOI 10.1016/j.jaad.2013.11.013
   Radtke MA, 2015, J DTSCH DERMATOL GES, V13, P674, DOI 10.1111/ddg.12643
   Roubille C, 2015, J RHEUMATOL, V42, P1767, DOI 10.3899/jrheum.141112
   Schabert VF, 2013, J MANAGE CARE PHARM, V19, P621, DOI 10.18553/jmcp.2013.19.8.621
   Schabert Vernon F, 2012, J Med Econ, V15, P264, DOI 10.3111/13696998.2011.644645
   Sommer DM, 2006, ARCH DERMATOL RES, V298, P321, DOI 10.1007/s00403-006-0703-z
   Sterry W, 2007, BRIT J DERMATOL, V157, P649, DOI 10.1111/j.1365-2133.2007.08068.x
   Vanderpuye-Orgle J, 2015, J AM ACAD DERMATOL, V72, P961, DOI 10.1016/j.jaad.2015.02.1099
   Wahl AK, 2002, QUAL HEALTH RES, V12, P250, DOI 10.1177/104973202129119874
NR 32
TC 5
Z9 5
U1 0
U2 1
PU JOURNAL OF DRUGS IN DERMATOLOGY
PI NEW YORK
PA 377 PARK AVE SOUTH, 6TH FLOOR, NEW YORK, NY 10016 USA
SN 1545-9616
J9 J DRUGS DERMATOL
JI J. Drugs Dermatol.
PD JUL
PY 2017
VL 16
IS 7
BP 651
EP 658
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FA6HD
UT WOS:000405543000002
PM 28697216
DA 2025-06-11
ER

PT J
AU Gupte, AA
   Sabek, OM
   Fraga, D
   Minze, LJ
   Nishimoto, SK
   Liu, JZ
   Afshar, S
   Gaber, L
   Lyon, CJ
   Gaber, AO
   Hsueh, WA
AF Gupte, Anisha A.
   Sabek, Omaima M.
   Fraga, Daniel
   Minze, Laurie J.
   Nishimoto, Satoru K.
   Liu, Joey Z.
   Afshar, Solmaz
   Gaber, Lillian
   Lyon, Christopher J.
   Gaber, A. Osama
   Hsueh, Willa A.
TI Osteocalcin Protects Against Nonalcoholic Steatohepatitis in a Mouse
   Model of Metabolic Syndrome
SO ENDOCRINOLOGY
LA English
DT Article
ID FATTY LIVER-DISEASE; ENDOPLASMIC-RETICULUM STRESS; DIET-INDUCED OBESITY;
   ACCELERATED ATHEROSCLEROSIS; INTERMITTENT INJECTIONS; MACROPHAGE
   INFILTRATION; INSULIN SENSITIVITY; BONE PROTEIN; OSTEOPONTIN; TISSUE
AB Nonalcoholic fatty liver disease, particularly its more aggressive form, nonalcoholic steatohepatitis (NASH), is associated with hepatic insulin resistance. Osteocalcin, a protein secreted by osteoblast cells in bone, has recently emerged as an important metabolic regulator with insulin-sensitizing properties. In humans, osteocalcin levels are inversely associated with liver disease. We thus hypothesized that osteocalcin may attenuate NASH and examined the effects of osteocalcin treatment in middle-aged (12-mo-old) male Ldlr(-/-) mice, which were fed a Western-style high-fat, high-cholesterol diet for 12 weeks to induce metabolic syndrome and NASH. Mice were treated with osteocalcin (4.5 ng/h) or vehicle for the diet duration. Osteocalcin treatment not only protected against Western-style high-fat, high-cholesterol diet-induced insulin resistance but substantially reduced multiple NASH components, including steatosis, ballooning degeneration, and fibrosis, with an overall reduction in nonalcoholic fatty liver disease activity scores. Further, osteocalcin robustly reduced expression of proinflammatory and profibrotic genes (Cd68, Mcp1, Spp1, and Col1a2) in liver and suppressed inflammatory gene expression in white adipose tissue. In conclusion, these results suggest osteocalcin inhibits NASH development by targeting inflammatory and fibrotic processes.
C1 [Gupte, Anisha A.] Houston Methodist Res Inst, Bioenerget Program, Houston, TX USA.
   [Sabek, Omaima M.; Fraga, Daniel; Afshar, Solmaz; Gaber, A. Osama] Houston Methodist Hosp, Dept Surg, Houston, TX 77030 USA.
   [Minze, Laurie J.] Houston Methodist Res Inst, Immunobiol Res Ctr, Houston, TX 77030 USA.
   [Nishimoto, Satoru K.] Univ Tennessee, Hlth Sci Ctr, Dept Microbiol Immunol & Biochem, Memphis, TN 38163 USA.
   [Liu, Joey Z.; Lyon, Christopher J.; Hsueh, Willa A.] Methodist Diabet & Metab Inst, Houston Methodist Res Inst, Houston, TX 77030 USA.
   [Gaber, Lillian] Houston Methodist Hosp, Dept Pathol, Houston, TX 77030 USA.
   [Liu, Joey Z.; Hsueh, Willa A.] Ohio State Univ, Dept Med, Div Endocrinol Diabet & Metab, Columbus, OH 43210 USA.
C3 Houston Methodist; Houston Methodist; Houston Methodist; University of
   Tennessee System; University of Tennessee Health Science Center; Houston
   Methodist; Houston Methodist; University System of Ohio; Ohio State
   University
RP Hsueh, WA (corresponding author), Ohio State Univ, Wexner Med Ctr, Diabet Res Ctr, McCampbell Hall,1581 Dodd Dr, Columbus, OH 43210 USA.
EM willa.hsueh@osumc.edu
RI Xiao, Liuling/AFR-2506-2022; Gaber, Ahmed/GPW-7781-2022; Gupte,
   Anisha/D-6756-2015
OI sabek, omaima/0000-0003-0919-0093; Gupte, Anisha/0000-0002-5173-1773
FU Houston Methodist Research Institute; American Heart Association; Vivian
   Smith Foundation; MacDonald Foundation; Patel Family Foundation
FX This work was supported by grants from Houston Methodist Research
   Institute (O.M.S.), American Heart Association (A.A.G.), Vivian Smith
   Foundation (A.O.G.), and MacDonald Foundation and the Patel Family
   Foundation (W.A.H.).
CR Aller R, 2011, ANN HEPATOL, V10, P50, DOI 10.1016/S1665-2681(19)31587-X
   Argo CK, 2009, J HEPATOL, V51, P371, DOI 10.1016/j.jhep.2009.03.019
   Bertola A, 2009, DIABETES, V58, P125, DOI 10.2337/db08-0400
   Brennan-Speranza TC, 2012, J CLIN INVEST, V122, P4172, DOI 10.1172/JCI63377
   Bruemmer D, 2003, J CLIN INVEST, V112, P1318, DOI 10.1172/JCI200318141
   Cawley J, 2012, J HEALTH ECON, V31, P219, DOI 10.1016/j.jhealeco.2011.10.003
   Collins AR, 2009, CIRC RES, V104, pe42, DOI 10.1161/CIRCRESAHA.108.188771
   Deng T, 2013, OBESITY INFLAMMATION, V2013, P25
   Deng T, 2013, CELL METAB, V17, P411, DOI 10.1016/j.cmet.2013.02.009
   Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI23621
   Farrell GC, 2006, HEPATOLOGY, V43, pS99, DOI 10.1002/hep.20973
   Fernández-Real JM, 2010, OSTEOPOROSIS INT, V21, P2101, DOI 10.1007/s00198-010-1174-9
   Ferron M, 2012, BONE, V50, P568, DOI 10.1016/j.bone.2011.04.017
   Giachelli CM, 1998, AM J PATHOL, V152, P353
   Gower BA, 2013, J CLIN ENDOCR METAB, V98, pE1173, DOI 10.1210/jc.2013-1203
   Gupte AA, 2013, ENDOCRINOLOGY, V154, P2650, DOI 10.1210/en.2012-2272
   Gupte AA, 2010, HEPATOLOGY, V52, P2001, DOI 10.1002/hep.23941
   Hill HS, 2014, HORM METAB RES, V46, P341, DOI 10.1055/s-0034-1368709
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Liu JJ, 2013, INT J MOL SCI, V14, P19782, DOI 10.3390/ijms141019782
   Mainous AG, 2007, DIABETOLOGIA, V50, P934, DOI 10.1007/s00125-006-0528-5
   Mehta SR, 2010, THER ADV ENDOCRINOL, V1, P101, DOI 10.1177/2042018810379587
   Neuschwander-Tetri BA, 2003, HEPATOLOGY, V37, P1202, DOI 10.1053/jhep.2003.50193
   NISHIMOTO SK, 1990, ANAL BIOCHEM, V186, P273, DOI 10.1016/0003-2697(90)90079-O
   NISHIMOTO SK, 1992, J BIOL CHEM, V267, P11600
   NISHIMOTO SK, 1985, J BIOL CHEM, V260, P2832
   NISHIMOTO SK, 1979, J BIOL CHEM, V254, P437
   Nomiyama T, 2007, J CLIN INVEST, V117, P2877, DOI 10.1172/JCI31986
   PIETSCHMANN P, 1990, BONE MINER, V8, P103, DOI 10.1016/0169-6009(90)90113-T
   Schuppan D, 2013, J GASTROEN HEPATOL, V28, P68, DOI 10.1111/jgh.12212
   Sheedfar F, 2014, AGING-US, V6, P281, DOI 10.18632/aging.100652
   Sheedfar F, 2013, AGING CELL, V12, P950, DOI 10.1111/acel.12128
   Tilg H, 2014, EXPERT OPIN DRUG DIS, V9, P687, DOI 10.1517/17460441.2014.911283
   Wang QQ, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/842598
   Yilmaz Y, 2013, DIGEST LIVER DIS, V45, P58, DOI 10.1016/j.dld.2012.08.017
   Yilmaz Y, 2011, SCAND J CLIN LAB INV, V71, P631, DOI 10.3109/00365513.2011.604427
   Zhou B, 2013, CELL CYCLE, V12, P1901, DOI 10.4161/cc.24929
   Zhou B, 2013, ENDOCRINOLOGY, V154, P1055, DOI 10.1210/en.2012-2144
NR 38
TC 56
Z9 65
U1 1
U2 18
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD DEC
PY 2014
VL 155
IS 12
BP 4697
EP 4705
DI 10.1210/en.2014-1430
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AX0UN
UT WOS:000346668000011
PM 25279794
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Ament, Z
   Masoodi, M
   Griffin, JL
AF Ament, Zsuzsanna
   Masoodi, Mojgan
   Griffin, Julian L.
TI Applications of metabolomics for understanding the action of peroxisome
   proliferator-activated receptors (PPARs) in diabetes, obesity and cancer
SO GENOME MEDICINE
LA English
DT Review
DE metabolic syndrome; obesity; peroxisome proliferator-activated
   receptors; type II diabetes; functional genomics; the metabolic syndrome
ID GENE-EXPRESSION; SPECIES-DIFFERENCES; OXIDATIVE STRESS; ACID OXIDATION;
   GAMMA LIGANDS; FATTY-ACIDS; ALPHA; RAT; METABOLISM; DELTA
AB The peroxisome proliferator-activated receptors (PPARs) are a set of three nuclear hormone receptors that together play a key role in regulating metabolism, particularly the switch between the fed and fasted state and the metabolic pathways involving fatty-acid oxidation and lipid metabolism. In addition, they have a number of important developmental and regulatory roles outside metabolism. The PPARs are also potent targets for treating type II diabetes, dyslipidemia and obesity, although a number of individual agonists have also been linked to unwanted side effects, and there is a complex relationship between the PPARs and the development of cancer. This review examines the part that metabolomics, including lipidomics, has played in elucidating the roles PPARs have in regulating systemic metabolism, as well as their role in aspects of drug-induced cancer and xenobiotic metabolism. These studies have defined the role PPAR delta plays in regulating fatty-acid oxidation in adipose tissue and the interaction between aging and PPAR alpha in the liver. The potential translational benefits of these approaches include widening the role of PPAR agonists and improved monitoring of drug efficacy.
C1 [Ament, Zsuzsanna; Masoodi, Mojgan; Griffin, Julian L.] Med Res Council Human Nutr Res, Elsie Widdowson Lab, Cambridge CB1 9NL, England.
   [Ament, Zsuzsanna; Masoodi, Mojgan; Griffin, Julian L.] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England.
C3 UK Research & Innovation (UKRI); Medical Research Council UK (MRC); MRC
   Human Nutrition Research; University of Cambridge; University of
   Cambridge
RP Griffin, JL (corresponding author), Med Res Council Human Nutr Res, Elsie Widdowson Lab, 120 Fulbourn Rd, Cambridge CB1 9NL, England.
EM jules.griffin@mrc-hnr.cam.ac.uk
RI Ament, Zsuzsanna/AGF-6631-2022; MASOODI, MOJGAN/P-1499-2019
OI Ament, Zsuzsanna/0000-0002-0316-4348; MASOODI,
   MOJGAN/0000-0001-9840-1731
FU Medical Research Council [UD99999906]; BBSRC [BB/H013539/1]; Wellcome
   Trust [093148/Z/10/Z]; EU (INHERITANCE); MRC ITTP training PhD
   studentship; BBSRC [BB/H013539/2, BB/H013539/1, BB/D524824/1] Funding
   Source: UKRI; MRC [MC_UP_A090_1006] Funding Source: UKRI; Wellcome Trust
   [093148/Z/10/Z] Funding Source: Wellcome Trust
FX JLG and MM are funded by the Medical Research Council (UD99999906). Work
   in the JLG lab is funded in addition by the BBSRC (BB/H013539/1), the
   Wellcome Trust (093148/Z/10/Z) and the EU (INHERITANCE). ZA is a
   recipient of an MRC ITTP training PhD studentship.
CR Angermüller S, 2009, HISTOCHEM CELL BIOL, V131, P459, DOI 10.1007/s00418-009-0563-7
   Atherton HJ, 2006, PHYSIOL GENOMICS, V27, P178, DOI 10.1152/physiolgenomics.00060.2006
   Atherton HJ, 2009, MOL SYST BIOL, V5, DOI 10.1038/msb.2009.18
   BAYLY AC, 1993, J CELL SCI, V104, P307
   Clayton TA, 2006, NATURE, V440, P1073, DOI 10.1038/nature04648
   Cohen G, 2011, DIABETES, V60, P2830, DOI 10.2337/db11-0347
   Connor SC, 2004, BIOMARKERS, V9, P364, DOI 10.1080/13547500400006005
   Delaney J, 2005, ARCH TOXICOL, V79, P208, DOI 10.1007/s00204-004-0625-5
   Dumas ME, 2007, NAT GENET, V39, P666, DOI 10.1038/ng2026
   Evans RM, 2004, NAT MED, V10, P355, DOI 10.1038/nm1025
   Fajas L, 1997, J BIOL CHEM, V272, P18779, DOI 10.1074/jbc.272.30.18779
   GIERA DD, 1991, FUND APPL TOXICOL, V16, P348, DOI 10.1016/0272-0590(91)90119-O
   Gonzalez FJ, 2008, TOXICOLOGY, V246, P2, DOI 10.1016/j.tox.2007.09.030
   Griffin JL, 2004, PHYSIOL GENOMICS, V17, P140, DOI 10.1152/physiolgenomics.00158.2003
   Griffin JL, 2001, ANAL BIOCHEM, V293, P16, DOI 10.1006/abio.2001.5096
   Gurung IS, 2011, CARDIOVASC RES, V92, P29, DOI 10.1093/cvr/cvr155
   Hoggatt J, 2010, LEUKEMIA, V24, P1993, DOI 10.1038/leu.2010.216
   Huang JT, 1999, NATURE, V400, P378, DOI 10.1038/22572
   Illig T, 2010, NAT GENET, V42, P137, DOI 10.1038/ng.507
   ISSEMANN I, 1990, NATURE, V347, P645, DOI 10.1038/347645a0
   Kadowaki T, 2002, J DIABETES COMPLICAT, V16, P41, DOI 10.1016/S1056-8727(01)00206-9
   Kaul S, 2010, CIRCULATION, V121, P1868, DOI 10.1161/CIR.0b013e3181d34114
   KELLER H, 1993, P NATL ACAD SCI USA, V90, P2160, DOI 10.1073/pnas.90.6.2160
   Kersten S, 1999, J CLIN INVEST, V103, P1489, DOI 10.1172/JCI6223
   Kettunen J, 2012, NAT GENET, V44, P269, DOI 10.1038/ng.1073
   Kim YG, 2011, MOL BIOSYST, V7, P1046, DOI 10.1039/c0mb00324g
   King RD, 2004, NATURE, V427, P247, DOI 10.1038/nature02236
   Kirschenlohr HL, 2006, NAT MED, V12, P705, DOI 10.1038/nm1432
   Klaunig JE, 2004, ANNU REV PHARMACOL, V44, P239, DOI 10.1146/annurev.pharmtox.44.101802.121851
   KLIEWER SA, 1995, CELL, V83, P813, DOI 10.1016/0092-8674(95)90194-9
   Knauf C, 2006, ENDOCRINOLOGY, V147, P4067, DOI 10.1210/en.2005-1536
   LAKE BG, 1983, LIFE SCI, V33, P249, DOI 10.1016/0024-3205(83)90383-1
   Lee CH, 2006, P NATL ACAD SCI USA, V103, P3444, DOI 10.1073/pnas.0511253103
   LEE SST, 1995, MOL CELL BIOL, V15, P3012
   Lengqvist J, 2004, MOL CELL PROTEOMICS, V3, P692, DOI 10.1074/mcp.M400003-MCP200
   Leone TC, 1999, P NATL ACAD SCI USA, V96, P7473, DOI 10.1073/pnas.96.13.7473
   Lim H, 1999, GENE DEV, V13, P1561, DOI 10.1101/gad.13.12.1561
   Manna SK, 2010, J PROTEOME RES, V9, P4176, DOI 10.1021/pr100452b
   Masoodi M, 2010, ANAL CHEM, V82, P8176, DOI 10.1021/ac1015563
   Medina-Gomez G, 2005, DIABETES, V54, P1706, DOI 10.2337/diabetes.54.6.1706
   Medina-Gomez G, 2007, PLOS GENET, V3, DOI 10.1371/journal.pgen.0030064
   Medina-Gomez G, 2009, DIS MODEL MECH, V2, P582, DOI 10.1242/dmm.003251
   Na HK, 2003, BIOCHEM PHARMACOL, V66, P1381, DOI 10.1016/S0006-2952(03)00488-X
   Nagy L, 1998, CELL, V93, P229, DOI 10.1016/S0092-8674(00)81574-3
   Nissen SE, 2007, NEW ENGL J MED, V356, P2457, DOI 10.1056/NEJMoa072761
   Ohta T, 2009, TOXICOL PATHOL, V37, P521, DOI 10.1177/0192623309336152
   Patterson AD, 2009, J PROTEOME RES, V8, P4293, DOI 10.1021/pr9004103
   Peters JM, 2012, NAT REV CANCER, V12, P181, DOI 10.1038/nrc3214
   Peters JM, 1997, CARCINOGENESIS, V18, P2029, DOI 10.1093/carcin/18.11.2029
   Podo F, 1999, NMR BIOMED, V12, P413, DOI 10.1002/(SICI)1099-1492(199911)12:7<413::AID-NBM587>3.0.CO;2-U
   Pogribny IP, 2008, MUTAT RES-FUND MOL M, V644, P17, DOI 10.1016/j.mrfmmm.2008.06.009
   Poudyal H, 2011, PROG LIPID RES, V50, P372, DOI 10.1016/j.plipres.2011.06.003
   Reddy JK, 2001, ANNU REV NUTR, V21, P193, DOI 10.1146/annurev.nutr.21.1.193
   Risérus U, 2008, DIABETES, V57, P332, DOI 10.2337/db07-1318
   Roberts LD, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-8-r75
   Roberts LD, 2009, GENOME MED, V1, DOI 10.1186/gm115
   Roberts RA, 2000, TOXICOL LETT, V112, P49, DOI 10.1016/S0378-4274(99)00243-X
   Roberts RA, 1996, ANN NY ACAD SCI, V804, P588, DOI 10.1111/j.1749-6632.1996.tb18647.x
   Salek RM, 2007, PHYSIOL GENOMICS, V29, P99, DOI 10.1152/physiolgenomics.00194.2006
   Savage DB, 2003, DIABETES, V52, P910, DOI 10.2337/diabetes.52.4.910
   Takahashi S, 2006, PHARMACOL RES, V53, P501, DOI 10.1016/j.phrs.2006.03.019
   Tang ZM, 2010, ANAL CHEM, V82, P7706, DOI 10.1021/ac1015497
   Tontonoz P, 2008, ANNU REV BIOCHEM, V77, P289, DOI 10.1146/annurev.biochem.77.061307.091829
   VidalPuig A, 1996, J CLIN INVEST, V97, P2553, DOI 10.1172/JCI118703
   Wang TJ, 2011, NAT MED, V17, P448, DOI 10.1038/nm.2307
   Wang T, 2010, J BIOL CHEM, V285, P7670, DOI 10.1074/jbc.M109.090175
   Wang YX, 2004, PLOS BIOL, V2, P1532, DOI 10.1371/journal.pbio.0020294
   Watkins SM, 2002, J LIPID RES, V43, P1809, DOI 10.1194/jlr.M200169-JLR200
   Xu J, 2004, ENDOCRINOLOGY, V145, P1087, DOI 10.1210/en.2003-1173
   Xu J, 2002, J BIOL CHEM, V277, P50237, DOI 10.1074/jbc.M201208200
   YU K, 1995, J BIOL CHEM, V270, P23975, DOI 10.1074/jbc.270.41.23975
   Zhao YH, 2011, PLOS ONE, V6, DOI [10.1371/journal.pone.0015816, 10.1371/journal.pone.0016470]
   Zhen Y, 2007, MOL ENDOCRINOL, V21, P2136, DOI 10.1210/me.2007-0150
NR 73
TC 45
Z9 54
U1 0
U2 54
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1756-994X
J9 GENOME MED
JI Genome Med.
PD APR 30
PY 2012
VL 4
AR 32
DI 10.1186/gm331
PG 12
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA 084WA
UT WOS:000314569200003
PM 22546357
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Goetz, SMM
   Lucas, T
   Granger, DA
AF Goetz, Stefan M. M.
   Lucas, Todd
   Granger, Douglas A.
TI Salivary uric acid dynamics are associated with stress response hormones
   among African American in an urban sample
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Stress Reactivity; Uric Acid; Trier Social Stress Test; Health
   Disparities; Purinergic Stress Response; Multisystem Stress
ID SOCIAL EVALUATIVE THREAT; METABOLIC SYNDROME; OXIDATIVE STRESS;
   SEX-DIFFERENCES; BLOOD-PRESSURE; RISK-FACTORS; CORTISOL; REACTIVITY;
   HEALTH; DISCRIMINATION
AB Acute physiological responses to psychosocial stressors are a potential pathway underlying racial disparities in stress-related illnesses. Uric acid (UA) is a potent antioxidant that has been linked to disparities in stress-related illnesses, and recent research has shown that UA is responsive to acute social stress. However, an examination of the relationships between the purinergic system and other commonly measured stress systems is lacking. Here, we measure and characterize associations of salivary uric acid (sUA) with markers of hypothalamic-pituitaryadrenal (HPA) axis activation, sympathetic-adreno-medullar (SAM) axis activation, and acute inflammation. A community sample of 103 African Americans (33 male, 70 female) completed the Trier Social Stress Test to induce social-evaluative threat. Passive drool collected before, during, and after the stressor task provided salivary reactivity measures of UA (sUA), cortisol, dehydroepiandrosterone sulfate (DHEAS), salivary alpha amylase (sAA - a surrogate marker of SAM activity) and C-reactive protein (sCRP). Multiple regressions revealed that total activation of cortisol, DHEAS, and sCRP were each positively associated with higher total activation of sUA. Additionally, DHEAS reactivity was positively associated with sUA reactivity. Relationships between HPAaxis markers and sUA were especially observed among younger and male participants. Overall, findings suggest potential coordination of stress systems with sUA in response to acute stress, which may further the contributions of biological stress processes to racial health disparities.
C1 [Goetz, Stefan M. M.; Lucas, Todd] Michigan State Univ, Coll Human Med, Charles Stewart Mott Dept Publ Hlth, 200 East 1st St, Flint, MI 48502 USA.
   [Granger, Douglas A.] Univ Calif Irvine, Sch Social Ecol, Dept Psychol Sci, Irvine, CA 92697 USA.
   [Granger, Douglas A.] Univ Calif Irvine, Inst Interdisciplinary Salivary Biosci Res, 4201 SBSG, Irvine, CA 92697 USA.
   [Granger, Douglas A.] Johns Hopkins Univ, Dept Int Hlth, Sch Med, 615 North Wolfe St, Baltimore, MD 21205 USA.
C3 Michigan State University; Michigan State University College of Human
   Medicine; University of California System; University of California
   Irvine; University of California System; University of California
   Irvine; Johns Hopkins University
RP Lucas, T (corresponding author), Michigan State Univ, Coll Human Med, Charles Stewart Mott Dept Publ Hlth, 200 East 1st St, Flint, MI 48502 USA.
EM goetzste@msu.edu; lucastod@msu.edu; dagrange@uci.edu
FU National Heart, Lung, and Blood Institute [R21HL097191]
FX This research was supported by the National Heart, Lung, and Blood
   Institute (R21HL097191) awarded to Todd Lucas. The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the National Heart, Lung, and Blood Institute. In the
   interest of full disclosure, DAG is founder and chief scientific and
   strategy advisor at Salimetrics LLC and Salivabio LLC and these
   relationships are managed by the policies of the committees on conflict
   of interest at the Johns Hopkins University School of Medicine and
   University of California at Irvine. We thank Mercedes Hendrickson,
   Nathan Weidner, Lenwood Hayman, Edyta Debowska, Kaitlyn Simmonds, Kevin
   Wynne, Rhiana Wegner, and the Clinical Research Center at Wayne State
   University for assistance with data collection. Finally, we appreciate
   biotechnical support with salivary assays provided by Carla Slike, Becky
   Zavacky, and Jessica Acevedo.
CR Acevedo AM, 2022, PSYCHONEUROENDOCRINO, V146, DOI 10.1016/j.psyneuen.2022.105948
   AMES BN, 1981, P NATL ACAD SCI-BIOL, V78, P6858, DOI 10.1073/pnas.78.11.6858
   Anagnostis P, 2009, J CLIN ENDOCR METAB, V94, P2692, DOI 10.1210/jc.2009-0370
   Aschbacher K, 2013, PSYCHONEUROENDOCRINO, V38, P1698, DOI 10.1016/j.psyneuen.2013.02.004
   Bancks MP, 2017, JAMA-J AM MED ASSOC, V318, P2457, DOI 10.1001/jama.2017.19546
   Boraschi D., 2014, Nanoparticles & the Immune System, P9
   Burnstock G, 2008, NAT REV DRUG DISCOV, V7, P575, DOI 10.1038/nrd2605
   Carnethon MR, 2017, CIRCULATION, V136, pE393, DOI 10.1161/CIR.0000000000000534
   Copeland VC, 2005, HEALTH SOC WORK, V30, P265, DOI 10.1093/hsw/30.3.265
   Copur S, 2022, EUR J INTERN MED, V103, P4, DOI 10.1016/j.ejim.2022.04.022
   Correa BHM, 2022, CURR NEUROPHARMACOL, V20, P1212, DOI 10.2174/1570159X19666210719142300
   de Kloet AD, 2017, J NEUROSCI, V37, P3478, DOI 10.1523/JNEUROSCI.3674-16.2017
   Dedovic K, 2009, NEUROIMAGE, V47, P864, DOI 10.1016/j.neuroimage.2009.05.074
   Dimsdale JE, 2008, J AM COLL CARDIOL, V51, P1237, DOI 10.1016/j.jacc.2007.12.024
   Drolet CE, 2020, J BEHAV MED, V43, P932, DOI 10.1007/s10865-020-00146-1
   El Ridi R, 2017, J ADV RES, V8, P487, DOI 10.1016/j.jare.2017.03.003
   Goodman AM, 2016, NEUROSCIENCE, V339, P396, DOI 10.1016/j.neuroscience.2016.10.002
   Granger DA, 1999, PSYCHONEUROENDOCRINO, V24, P567, DOI 10.1016/S0306-4530(99)00013-X
   Hayes AF, 2018, A regression-based approach, VSecond
   Hayes AF, 2017, COMMUN METHODS MEAS, V11, P1, DOI 10.1080/19312458.2016.1271116
   Heidari S, 2017, EPIDEMIOL SERV SAUDE, V26, P665, DOI 10.5123/S1679-49742017000300025
   Johnson RJ, 2005, J AM SOC NEPHROL, V16, P1909, DOI 10.1681/ASN.2005010063
   Kanbay M, 2016, EUR J INTERN MED, V29, P3, DOI 10.1016/j.ejim.2015.11.026
   Kang DH, 2005, J AM SOC NEPHROL, V16, P3553, DOI 10.1681/ASN.2005050572
   Kang Duk-Hee, 2014, Electrolyte Blood Press, V12, P1, DOI 10.5049/EBP.2014.12.1.1
   King LS, 2020, PSYCHONEUROENDOCRINO, V115, DOI 10.1016/j.psyneuen.2020.104651
   KIRSCHBAUM C, 1993, NEUROPSYCHOBIOLOGY, V28, P76, DOI 10.1159/000119004
   Kool M, 2011, IMMUNITY, V34, P527, DOI 10.1016/j.immuni.2011.03.015
   Kroboth PD, 1999, J CLIN PHARMACOL, V39, P327, DOI 10.1177/00912709922007903
   Latourte A, 2018, CURR OPIN RHEUMATOL, V30, P183, DOI 10.1097/BOR.0000000000000472
   Laurent HK, 2016, BIOL PSYCHOL, V118, P17, DOI 10.1016/j.biopsycho.2016.04.066
   Lewis TT, 2018, CURR DIR PSYCHOL SCI, V27, P176, DOI 10.1177/0963721418770442
   Liu JJW, 2017, PSYCHONEUROENDOCRINO, V82, P26, DOI 10.1016/j.psyneuen.2017.04.007
   Lovallo WR, 2015, PSYCHOSOM MED, V77, P212, DOI 10.1097/PSY.0000000000000173
   Lucas T, 2023, SOC SCI MED, V316, DOI 10.1016/j.socscimed.2022.115019
   Lucas T, 2020, BIOL PSYCHOL, V153, DOI 10.1016/j.biopsycho.2020.107882
   Lucas T, 2017, PSYCHONEUROENDOCRINO, V86, P104, DOI 10.1016/j.psyneuen.2017.09.008
   Lucas T, 2017, PSYCHOSOM MED, V79, P293, DOI 10.1097/PSY.0000000000000406
   Lucas T, 2016, HEALTH PSYCHOL, V35, P366, DOI 10.1037/hea0000284
   Maninger N, 2009, FRONT NEUROENDOCRIN, V30, P65, DOI 10.1016/j.yfrne.2008.11.002
   MANOWITZ P, 1993, BIOL PSYCHOL, V36, P223, DOI 10.1016/0301-0511(93)90019-5
   Maslanik T, 2013, BRAIN BEHAV IMMUN, V28, P54, DOI 10.1016/j.bbi.2012.10.014
   Miller R, 2018, PSYCHONEUROENDOCRINO, V90, P194, DOI 10.1016/j.psyneuen.2017.12.019
   Mrug S, 2017, AM J MED SCI, V353, P336, DOI 10.1016/j.amjms.2017.01.008
   Nakanishi N, 2003, EUR J EPIDEMIOL, V18, P523, DOI 10.1023/A:1024600905574
   Ortiz R, 2015, PROG NEURO-PSYCHOPH, V57, P117, DOI 10.1016/j.pnpbp.2014.10.016
   Otani N, 2023, FRONT NEUROL, V14, DOI 10.3389/fneur.2023.1164756
   Prall SP, 2018, VITAM HORM, V108, P125, DOI 10.1016/bs.vh.2018.01.023
   Rohleder N, 2006, PSYCHOPHYSIOLOGY, V43, P645, DOI 10.1111/j.1469-8986.2006.00457.x
   Ruggiero C, 2006, EUR HEART J, V27, P1174, DOI 10.1093/eurheatj/ehi879
   Sautin YY, 2008, NUCLEOS NUCLEOT NUCL, V27, P608, DOI 10.1080/15257770802138558
   Tuttle KR, 2001, AM J CARDIOL, V87, P1411, DOI 10.1016/S0002-9149(01)01566-1
   Vernerová A, 2021, CLIN CHEM LAB MED, V59, P797, DOI 10.1515/cclm-2020-1533
   Virdis A, 2014, MATURITAS, V78, P179, DOI 10.1016/j.maturitas.2014.04.012
   Wan H, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00055
   Wang YT, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-96959-4
   Waring WS, 2003, CLIN SCI, V105, P425, DOI 10.1042/CS20030149
   Waring WS, 2001, J CARDIOVASC PHARM, V38, P365, DOI 10.1097/00005344-200109000-00005
   Watanabe S, 2002, HYPERTENSION, V40, P355, DOI 10.1161/01.HYP.0000028589.66335.AA
   Williams DR, 2012, J HEALTH SOC BEHAV, V53, P279, DOI 10.1177/0022146512455804
   Williams DR, 2005, HEALTH AFFAIR, V24, P325, DOI 10.1377/hlthaff.24.2.325
   Williams S., 2022, Salivary uric acid reactivity to discrimination stress and associations with cardiometabolic risk
   Woerner J, 2019, PSYCHONEUROENDOCRINO, V101, P19, DOI 10.1016/j.psyneuen.2018.10.025
   Yoo TW, 2005, CIRC J, V69, P928, DOI 10.1253/circj.69.928
   Zhu YZ, 2014, BIOCHEM BIOPH RES CO, V447, P707, DOI 10.1016/j.bbrc.2014.04.080
NR 65
TC 1
Z9 1
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD OCT
PY 2024
VL 168
AR 107120
DI 10.1016/j.psyneuen.2024.107120
EA JUL 2024
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA YV5P5
UT WOS:001271276400001
PM 39002453
DA 2025-06-11
ER

PT J
AU Vetrani, C
   De Simone, G
   Saia, V
   Barrea, L
   Muscogiuri, G
   Graziadio, C
   De Bartolomeis, A
   Macchia, PE
   Colao, A
AF Vetrani, Claudia
   De Simone, Giuseppe
   Saia, Viviana
   Barrea, Luigi
   Muscogiuri, Giovanna
   Graziadio, Chiara
   De Bartolomeis, Andrea
   Macchia, Paolo E.
   Colao, Annamaria
TI Diet quality in patients with treatment-resistant schizophrenia: time
   for improving nutritional recommendations
SO MINERVA ENDOCRINOLOGY
LA English
DT Article; Early Access
DE Schizophrenia; treatment-resistant; Antipsychotic agents; Insulin
   resistance; Diabetes mellitus; type 2; Car- diovascular diseases
ID WEIGHT-GAIN; ANTIPSYCHOTIC-DRUGS; METABOLIC SYNDROME; RISK-FACTORS;
   FATTY-ACIDS; GUIDELINES; ADULTS; METAANALYSIS; DISEASE; OBESITY
AB BACKGROUND: Treatment-resistant schizophrenia (TRS) is a severe psychiatric disorder that is associated with a high level of psychotic symptoms and cognitive deficit as well as poor functioning, and an increased risk of mortality for cardiometabolic diseases. Some studies suggest that lifestyle, particularly diet, could represent a risk factor for obesity and its metabolic complications in these patients. METHODS: This cross-sectional study aimed to evaluate diet quality and eating habits in individuals with TRS. Seventeen participants (13M/4F aged 37.8 +/- 13 years) were recruited to assess dietary composition and food groups consumption by a 7days food record to assess. In addition, demographic and clinical data were collected. RESULTS: Most of the participants were overweight/obese (82%) and only 35% performed physical activity. As compared to nutritional recommendations, participants presented an insufficient intake of fiber (1 5.9 +/- 3.2 g/day), vitamins (thiamine, riboflavin, vitamin A, D, and E), minerals (calcium, magnesium, selenium, and iron), and polyunsaturated fatty acids (2.11 +/- 0.8%), likely triggered by the low consumption plant-based foods (legumes, fruit, vegetables, and nuts) and fish. Participants exceeded the intake of saturated fatty acids (11.6 +/- 3.4%) and cholesterol (242 +/- 124 mg/day), and simple sugars (15.2 +/- 3.9%) which were mainly related to greater consumption of red meat and processed meat, and sweet foods, respectively. CONCLUSIONS: Individuals with TRS presented low diet quality and did not comply with the nutritional recommendations. These results support the importance of including nutritional assessment in the management of individuals with TRS.
C1 [Vetrani, Claudia; Barrea, Luigi] Pegaso Telemat Univ, Dept Wellbeing Nutr & Sport, Naples, Italy.
   [Vetrani, Claudia; Barrea, Luigi; Muscogiuri, Giovanna; Graziadio, Chiara; Colao, Annamaria] Univ Naples Federico II, Ctr Italiano Cura & Benessere Paziente Obesita CIB, Naples, Italy.
   [De Simone, Giuseppe; Saia, Viviana; De Bartolomeis, Andrea] Univ Naples Federico II, Unit Treatment Resistant Psychosis, Dept Neurosci, Lab Mol & Translat Psychiat,Sect Psychiat, Naples, Italy.
   [Muscogiuri, Giovanna; Graziadio, Chiara; Macchia, Paolo E.; Colao, Annamaria] Univ Naples Federico II, Dept Clin Med & Surg, Unit Endocrinol, Naples, Italy.
   [Muscogiuri, Giovanna; De Bartolomeis, Andrea; Macchia, Paolo E.; Colao, Annamaria] Univ Naples Federico II, Educ Hlth & Sustainable Dev Program, Naples, Italy.
C3 Pegaso Online University; University of Naples Federico II; University
   of Naples Federico II; University of Naples Federico II; University of
   Naples Federico II
RP Vetrani, C (corresponding author), Univ Naples Federico II, Ctr Italiano Cura & Benessere Paziente Obesita CIB, Dept Humanities, Via Porzio, I-80143 Naples, Italy.
EM c.vetrani@libero.it
RI Macchia, Paolo Emidio/B-7391-2012; De Simone, Giuseppe/IQR-6459-2023;
   Claudia, Vetrani/D-3306-2018; Barrea, Luigi/K-6551-2016; Colao,
   Annamaria/A-7671-2011
FU European Union - Next Generation EU - PNRR M6C2 - Investment 2.1
   Enhancement and strengthening of biomedical research [C63C22001460007,
   NHS-PNRR-MR1-2022-12375654]
FX This study is part of the project "RISKMet" (CUP-code C63C22001460007)
   funded by the European Union - Next Generation EU - PNRR M6C2 -
   Investment 2.1 Enhancement and strengthening of biomedical research in
   the NHS-PNRR-MR1-2022-12375654.
CR Abu Bakar NAF, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-17388-5
   Alkerwi A, 2015, BMJ OPEN, V5, DOI 10.1136/bmjopen-2014-006814
   Alvarez-Jiménez M, 2008, BRIT J PSYCHIAT, V193, P101, DOI 10.1192/bjp.bp.107.042853
   [Anonymous], 2018, WHO
   Aucoin M, 2020, NEUROPSYCHOBIOLOGY, V79, P20, DOI 10.1159/000493399
   Barone A, 2023, J COMMUNITY PSYCHOL, V51, P154, DOI 10.1002/jcop.22886
   Barrea L, 2021, J TRANSL MED, V19, DOI 10.1186/s12967-021-03199-1
   Barrea L, 2021, NUTRIENTS, V13, DOI 10.3390/nu13113762
   Barrea L, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/6101254
   Barrea L, 2017, CLIN NUTR, V36, P293, DOI 10.1016/j.clnu.2015.12.007
   Bayer S, 2022, CURR OPIN CLIN NUTR, V25, P265, DOI 10.1097/MCO.0000000000000840
   Bernardo M, 2009, EUR PSYCHIAT, V24, P431, DOI 10.1016/j.eurpsy.2009.07.010
   Biró G, 2002, EUR J CLIN NUTR, V56, pS25, DOI 10.1038/sj.ejcn.1601426
   Bobes J, 2003, SCHIZOPHR RES, V62, P77, DOI 10.1016/S0920-9964(02)00431-0
   Castillo-Sánchez M, 2017, CLIN EXP HYPERTENS, V39, P441, DOI 10.1080/10641963.2016.1267200
   Celik O, 2021, MINERVA ENDOCRINOL, V46, P131, DOI 10.23736/S2724-6507.20.03361-1
   Centro di Ricerca Alimenti e la Nutrizione, 2018, Linee Guida per una sana alimentazione
   Charlson FJ, 2018, SCHIZOPHRENIA BULL, V44, P1195, DOI 10.1093/schbul/sby058
   Correll Christoph U, 2021, J Clin Psychiatry, V82, DOI 10.4088/JCP.MY20096AH1C
   Danan A, 2022, FRONT PSYCHIATRY, V13, DOI 10.3389/fpsyt.2022.951376
   Dayabandara M, 2017, NEUROPSYCH DIS TREAT, V13, DOI 10.2147/NDT.S113099
   de Bartolomeis Andrea, 2022, Pharmacol Ther, V236, P108236, DOI 10.1016/j.pharmthera.2022.108236
   Emadian A, 2015, BRIT J NUTR, V114, P1656, DOI 10.1017/S0007114515003475
   Farquhar WB, 2015, J AM COLL CARDIOL, V65, P1042, DOI 10.1016/j.jacc.2014.12.039
   Fond G, 2019, EUR ARCH PSY CLIN N, V269, P985, DOI 10.1007/s00406-018-0908-0
   Garcia-Rizo C, 2020, PROG NEURO-PSYCHOPH, V101, DOI 10.1016/j.pnpbp.2020.109910
   Hjorthoj C, 2017, LANCET PSYCHIAT, V4, P295, DOI 10.1016/S2215-0366(17)30078-0
   Horsdal HT, 2017, HUM PSYCHOPHARM CLIN, V32, DOI 10.1002/hup.2632
   Howes OD, 2017, AM J PSYCHIAT, V174, P216, DOI 10.1176/appi.ajp.2016.16050503
   Iasevoli F, 2016, PROG NEURO-PSYCHOPH, V65, DOI 10.1016/j.pnpbp.2015.08.010
   Iqbal E, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0243437
   Kim EJ, 2017, NUTR RES, V45, P10, DOI 10.1016/j.nutres.2017.07.001
   Leonard BE, 2012, J PSYCHOPHARMACOL, V26, P33, DOI 10.1177/0269881111431622
   Leucht S, 2016, SCHIZOPHRENIA BULL, V42, pS90, DOI 10.1093/schbul/sbv167
   Liu CC, 2021, TRIALS, V22, DOI 10.1186/s13063-021-05123-w
   Malan-Müller S, 2016, SCHIZOPHR RES, V170, P1, DOI 10.1016/j.schres.2015.11.011
   Manchia M, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9080875
   Marion-Letellier R, 2015, IUBMB LIFE, V67, P659, DOI 10.1002/iub.1428
   Medina-Hernández V, 2007, J PSYCHIATR RES, V41, P652, DOI 10.1016/j.jpsychires.2006.02.010
   Moreno-Küstner B, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0195687
   Mf M, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0234121
   Neuenschwander M, 2020, PLOS MED, V17, DOI 10.1371/journal.pmed.1003347
   Norwitz NG, 2020, CURR OPIN ENDOCRINOL, V27, P269, DOI 10.1097/MED.0000000000000564
   Olfson M, 2015, JAMA PSYCHIAT, V72, P1172, DOI 10.1001/jamapsychiatry.2015.1737
   Patnode CD, 2022, JAMA-J AM MED ASSOC, V328, P375, DOI 10.1001/jama.2022.7408
   Paton C, 2004, ACTA PSYCHIAT SCAND, V110, P299, DOI 10.1111/j.1600-0447.2004.00372.x
   Pillinger T, 2020, LANCET PSYCHIAT, V7, P64, DOI 10.1016/S2215-0366(19)30416-X
   Reynolds A, 2019, LANCET, V393, P434, DOI 10.1016/S0140-6736(18)31809-9
   Scheen A J, 2004, Minerva Endocrinol, V29, P31
   Sethi Shebani, 2022, J Psychiatr Brain Sci, V7, DOI 10.20900/jpbs.20220009
   Simonelli-Muñoz AJ, 2012, INT J MENT HEALTH NU, V21, P220, DOI 10.1111/j.1447-0349.2012.00821.x
   Siskind D, 2017, CAN J PSYCHIAT, V62, P772, DOI 10.1177/0706743717718167
   Societa Italiana di Nutrizione Umana, 2014, LARN: Reference Intake Levels of Nutrients and Energy
   Steur M, 2021, J AM HEART ASSOC, V10, DOI 10.1161/JAHA.120.019814
   Storz MA, 2023, BRIT J NUTR, V129, P1023, DOI 10.1017/S0007114522001908
   van Zonneveld SM, 2022, CURR OPIN PSYCHIATR, V35, P177, DOI 10.1097/YCO.0000000000000791
   Vassilopoulou Emilia, 2022, Toxicol Rep, V9, P120, DOI 10.1016/j.toxrep.2022.01.003
   von Elm E, 2007, LANCET, V370, P1453, DOI 10.1016/S0140-6736(07)61602-X
   Whitney Z, 2015, EUR J CLIN PHARMACOL, V71, P389, DOI 10.1007/s00228-015-1807-1
   World Health Organization, 2024, Body mass index (BMI)
   Yang WJ, 2020, PSYCHIAT DANUB, V32, P46, DOI 10.24869/psyd.2020.46
   Madera PZ, 2022, REV PSIQUIATR SALUD, V15, P54, DOI 10.1016/j.rpsm.2019.10.003
   ,, 2018, Lancet (British edition), V392, P1789, DOI 10.1016/s0140-6736(18)32279-7
NR 63
TC 1
Z9 1
U1 2
U2 2
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 2724-6507
EI 2724-6116
J9 MINERVA ENDOCRINOL
JI Minerva Endocrinol.
PD 2024 NOV 20
PY 2024
DI 10.23736/S2724-6507.24.04158-7
EA NOV 2024
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA M8H9S
UT WOS:001359900600001
PM 39565366
DA 2025-06-11
ER

PT J
AU Orakzai, RH
   Orakzal, SH
   Nasir, K
   Roguin, A
   Pimentel, I
   Carvalho, JAM
   Meneghello, R
   Blumenthal, RS
   Santos, RD
AF Orakzai, RH
   Orakzal, SH
   Nasir, K
   Roguin, A
   Pimentel, I
   Carvalho, JAM
   Meneghello, R
   Blumenthal, RS
   Santos, RD
TI Association of increased cardiorespiratory fitness with low risk for
   clustering of metabolic syndrome components in asymptomatic men
SO ARCHIVES OF MEDICAL RESEARCH
LA English
DT Article
DE metabolic syndrome; cardiorespiratory fitness; atherosclerosis; stress
   test
ID TIME PHYSICAL-ACTIVITY; DEPENDENT DIABETES-MELLITUS;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; MUSCLE TRIGLYCERIDE;
   SKELETAL-MUSCLE; AEROBIC FITNESS; EXERCISE; MORTALITY; CLASSIFICATION
AB Background. From a preventive aspect, it is especially important to investigate the lifestyle risk factors associated with cardiovascular disease (CVD). The purpose of this study was to determine the relationship of increasing metabolic syndrome (MS) components across increasing levels of estimated cardiorespiratory fitness (CRF) in asymptomatic young to middle-aged men.
   Methods. We studied 449 consecutive asymptomatic men (47 +/- 7 years) who underwent a maximal treadmill exercise test according to the Bruce protocol. Cardiorespiratory fitness (CRF) was divided into textiles based on metabolic equivalents (METs). The following MS components were studied: 1) waist circumference > 102 cm; 2) serum triglycerides >= 150 mg/dL; 3) HDL cholesterol levels of <40 rng/dL; 4) fasting blood glucose (FBG) >= 110 mg/dL or 5) blood pressure : >= 130/85 mmHg or treated hypertension. Multinomial logistic regression was used to investigate the relationship between clustering of MS components and CRF as determined by metabolic equivalents (METs). We used polytomous logistic regression to determine the likelihood of clustering of increasing components of metabolic syndrome with intermediate (2(nd) tertile) and low (1(st) tertile) levels of CRF as compared to those with highest levels of CRF (3(rd) tertile).
   Results. Overall in the study population, zero, 1, 2 and >= 3 (i.e., metabolic syndrome) risk factors for MS were observed in 29% (n = 129), 26% (n = 118), 22% (n = 98) and 23% (n = 104) men, respectively. The mean METS achieved in the study population was 10 +/- 2 (range 4-20). Nearly half (49%) of individuals with the highest levels of CRF had no MS risk factors whereas only 18% of those with low CRF (METS <9) had no MS risk factors. On the other end of the spectrum, the prevalence of MS (>= 3 MS risk factors) increased significantly across decreasing levels of CRF (6, 22, 33% p <0.0001 for trend). Multivariable polytomous logistic regression (adjusting for ace, smoking, cholesterollowering therapy) demonstrated that individuals with low CRF (1(st) tertile of METS) compared to those with highest CRF had 3.1- (p = 0.001) and 11.8- (p <0.0001) fold higher risk of having 2 and >= 3 MS components, respectively. Similar results were observed when the analyses was repeated adjusting for Framingham risk score.
   Conclusions. Asymptomatic men with low levels of CRF have a greater likelihood for clustering of MS components and thus are at higher CVD risk. Further studies are needed to define the risk of cardiovascular disease in patients with intermediate levels of CRF and address which treatment strategies are most important given an individual's risk profile. (C) 2006 IMSS. Published by Elsevier Inc.
C1 Univ Pittsburgh, Dept Med, Pittsburgh, PA USA.
   Johns Hopkins Univ, Sch Med, Ciccarone Prevent Cardiol Ctr, Baltimore, MD USA.
   Albert Einstein Hosp, Albert Einstein Prevent Med Ctr, Inst Ensino & Pesquisa Israelita, Sao Paulo, Brazil.
   Univ Sao Paulo, Med Sch Hosp, Inst Heart, Lipid Clin, Sao Paulo, Brazil.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Johns Hopkins University; Hospital Israelita Albert
   Einstein; Universidade de Sao Paulo
RP HCFMUSP, InCor, Unidade Clin Lipides, Av Dr Eneas C Aguiar 44,2 Andar Anexo 2, BR-05403000 Sao Paulo, Brazil.
EM rdsf@uol.com.br
RI Blumenthal, Roger/H-3223-2018; ROGUIN, Ariel/LNR-1950-2024; Nasir,
   Khurram/A-2317-2008; Santos Filho, Raul/A-1170-2010
OI Santos Filho, Raul/0000-0002-9860-6582
CR Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   [Anonymous], 1996, PHYS ACTIVITY HLTH, P1
   [Anonymous], 2000, Obesity: preventing and managing the global epidemic: report of a WHO consultation, P253
   Astrand P., 2003, Textbook of Work Physiology. Physiological Basis of Exercise, V4th
   Blair SN, 1996, JAMA-J AM MED ASSOC, V276, P205, DOI 10.1001/jama.276.3.205
   Boreham CA, 2001, PUBLIC HEALTH, V115, P373
   BRUCE RA, 1973, AM HEART J, V85, P546, DOI 10.1016/0002-8703(73)90502-4
   FAGARD R, 1991, J APPL PHYSIOL, V70, P357, DOI 10.1152/jappl.1991.70.1.357
   Franks PW, 2004, DIABETES CARE, V27, P1187, DOI 10.2337/diacare.27.5.1187
   Franks PW, 2003, MED SCI SPORT EXER, V35, P1998, DOI 10.1249/01.MSS.0000099109.73351.81
   FROHLICH ED, 1995, CAN J CARDIOL, V11, pH35
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Grundy SM, 2004, ARTERIOSCL THROM VAS, V24, pE19, DOI 10.1161/01.ATV.0000112379.88385.67
   Gumbiner B, 1996, J CLIN EPIDEMIOL, V49, P267, DOI 10.1016/0895-4356(95)00561-7
   HAFFNER SM, 1992, DIABETES, V41, P715, DOI 10.2337/diabetes.41.6.715
   Hambrecht R, 2000, NEW ENGL J MED, V342, P454, DOI 10.1056/NEJM200002173420702
   HANSEN JE, 1987, AM J CARDIOL, V59, P669, DOI 10.1016/0002-9149(87)91190-8
   HELMRICH SP, 1991, NEW ENGL J MED, V325, P147, DOI 10.1056/NEJM199107183250302
   HUGHES VA, 1993, AM J PHYSIOL, V264, pE855, DOI 10.1152/ajpendo.1993.264.6.E855
   Hunt KJ, 2000, GENET EPIDEMIOL, V19, P395, DOI 10.1002/1098-2272(200012)19:4<395::AID-GEPI10>3.0.CO;2-3
   HURLEY BF, 1986, J APPL PHYSIOL, V60, P562, DOI 10.1152/jappl.1986.60.2.562
   Jurca R, 2004, MED SCI SPORT EXER, V36, P1301, DOI 10.1249/01.MSS.0000135780.88930.A9
   Katzmarzyk PT, 2003, MED SCI SPORT EXER, V35, P1703, DOI 10.1249/01.MSS.0000089337.73244.9B
   Kelley DE, 2001, DIABETES CARE, V24, P933, DOI 10.2337/diacare.24.5.933
   Kullo IJ, 2002, AM J CARDIOL, V90, P795, DOI 10.1016/S0002-9149(02)02617-6
   Laaksonen DE, 2003, DIABETES CARE, V26, P2156, DOI 10.2337/diacare.26.7.2156
   Laaksonen DE, 2002, DIABETES CARE, V25, P1612, DOI 10.2337/diacare.25.9.1612
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lakka TA, 2003, MED SCI SPORT EXER, V35, P1279, DOI 10.1249/01.MSS.0000079076.74931.9A
   LAKKA TA, 1994, NEW ENGL J MED, V330, P1549, DOI 10.1056/NEJM199406023302201
   Laukkanen JA, 2001, ARCH INTERN MED, V161, P825, DOI 10.1001/archinte.161.6.825
   Lorenzo C, 2003, DIABETES CARE, V26, P3153, DOI 10.2337/diacare.26.11.3153
   Lynch J, 1996, ARCH INTERN MED, V156, P1307, DOI 10.1001/archinte.156.12.1307
   Malik S, 2004, CIRCULATION, V110, P1245, DOI 10.1161/01.CIR.0000140677.20606.0E
   MANSON JE, 1991, LANCET, V338, P774, DOI 10.1016/0140-6736(91)90664-B
   Mayer-Davis EJ, 1998, JAMA-J AM MED ASSOC, V279, P669, DOI 10.1001/jama.279.9.669
   McConnell T.R., 1987, J CARDIOPULMONARY RE, V7, P324, DOI DOI 10.1097/00008483-198707000-00002
   MILANI RV, 1995, AM J CARDIOL, V75, P940, DOI 10.1016/S0002-9149(99)80693-6
   Montgomery HE, 1998, NATURE, V393, P221, DOI 10.1038/30374
   Nyholm B, 1996, DIABETOLOGIA, V39, P813, DOI 10.1007/s001250050515
   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Ross R, 2000, ANN INTERN MED, V133, P92, DOI 10.7326/0003-4819-133-2-200007180-00008
   Rothman KJ, 2008, MODERN EPIDEMIOLOGY
   Schmidt MI, 1996, DIABETES CARE, V19, P414, DOI 10.2337/diacare.19.5.414
   Tabata I, 1999, J APPL PHYSIOL, V86, P909, DOI 10.1152/jappl.1999.86.3.909
   Thompson PD, 2003, ARTERIOSCL THROM VAS, V23, pE42, DOI 10.1161/01.ATV.0000089628.63625.D4
   Wägner AM, 2000, CLIN CHEM, V46, P1830
   WALLACE MB, 1991, MED SCI SPORT EXER, V23, P199
   Whaley MH, 1999, MED SCI SPORT EXER, V31, P287, DOI 10.1097/00005768-199902000-00013
NR 50
TC 21
Z9 25
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0188-4409
EI 1873-5487
J9 ARCH MED RES
JI Arch. Med. Res.
PD MAY
PY 2006
VL 37
IS 4
BP 522
EP 528
DI 10.1016/j.arcmed.2005.08.004
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 037JK
UT WOS:000237142700017
PM 16624653
DA 2025-06-11
ER

PT J
AU Talebi, M
   Talebi, M
   Farkhondeh, T
   Simal-Gandara, J
   Kopustinskiene, DM
   Bernatoniene, J
   Pourbagher-Shahri, AM
   Samarghandian, S
AF Talebi, Marjan
   Talebi, Mohsen
   Farkhondeh, Tahereh
   Simal-Gandara, Jesus
   Kopustinskiene, Dalia M.
   Bernatoniene, Jurga
   Pourbagher-Shahri, Ali Mohammad
   Samarghandian, Saeed
TI Promising Protective Effects of Chrysin in Cardiometabolic Diseases
SO CURRENT DRUG TARGETS
LA English
DT Review
DE Chrysin; metabolic syndrome; diabetes mellitus; cardiovascular diseases;
   flavonoid; cardioprotective effects
ID METABOLIC SYNDROME; PHARMACOLOGICAL-ACTIVITIES; OROXYLUM-INDICUM;
   OXIDATIVE STRESS; FLAVONOIDS; RATS; SUPPRESSION; PROTEIN
AB Cardiometabolic diseases (CMD) have caused a great burden in terms of morbidity and mortality worldwide. The vicious cycle of CMD consists of type II diabetes, hypertension, dyslipidemia, obesity, and atherosclerosis. They have interlinked pathways, interacting and interconnecting with each other. The natural flavonoid chrysin has been shown to possess a broad spectrum of therapeutic activities for human health. Herein, we did an in-depth investigation of the novel mechanisms of chrysin's cardioprotection against cardiometabolic disorders. Studies have shown that chrysin protects the cardiovascular system by enhancing the intrinsic antioxidative defense system. This antioxidant property enhanced by chrysin protects against several risk factors of cardiometabolic disorders, including atherosclerosis, vascular inflammation and dysfunction, platelet aggregation, hypertension, dyslipidemia, cardiotoxicity, myocardial infarction, injury, and remodeling, diabetes-induced injuries, and obesity. Chrysin also exhibited anti-inflammatory mechanisms through inhibiting pro-inflammatory pathways, including NF-kappa B, MAPK, and PI3k/Akt. Furthermore, chrysin modulated NO, RAS, AGE/RAGE, and PPARs pathways which contributed to the risk factors of cardiometabolic disorders. Taken together, the mechanisms in which chrysin protects against cardiometabolic disorder are more than merely antioxidation and anti-inflammation in the cardiovascular system.
C1 [Talebi, Marjan] Shahid Beheshti Univ Med Sci, Sch Pharm, Dept Pharmacognosy, Tehran 1991953381, Iran.
   [Talebi, Mohsen] Univ Texas Arlington, Dept Chem & Biochem, Arlington, TX 76019 USA.
   [Talebi, Mohsen] Viatris Pharmaceut Inc, 3300 Res Plaza, San Antonio, TX 78235 USA.
   [Farkhondeh, Tahereh] Birjand Univ Med Sci, Cardiovasc Dis Res Ctr, Birjand, Iran.
   [Farkhondeh, Tahereh] Birjand Univ Med Sci, Fac Pharm, Birjand, Iran.
   [Simal-Gandara, Jesus] Univ Vigo, Fac Sci, Dept Analyt & Food Chem, Nutr & Bromatol Grp, Ourense Campus, E-32004 Orense, Spain.
   [Kopustinskiene, Dalia M.; Bernatoniene, Jurga] Lithuanian Univ Hlth Sci, Med Acad, Fac Pharm, Inst Pharmaceut Technol, Sukileliu Pr 13, LT-50161 Kaunas, Lithuania.
   [Bernatoniene, Jurga] Lithuanian Univ Hlth Sci, Med Acad, Fac Pharm, Dept Drug Technol & Social Pharm, Sukileliu Pr 13, LT-50161 Kaunas, Lithuania.
   [Pourbagher-Shahri, Ali Mohammad] Birjand Univ Med Sci, Med Toxicol & Drug Abuse Res Ctr MTDRC, Birjand, Iran.
   [Samarghandian, Saeed] Neyshabur Univ Med Sci, Noncommunicable Dis Res Ctr, Neyshabur, Iran.
C3 Shahid Beheshti University Medical Sciences; University of Texas System;
   University of Texas Arlington; Birjand University of Medical Sciences;
   Birjand University of Medical Sciences; Universidade de Vigo; Lithuanian
   University of Health Sciences; Lithuanian University of Health Sciences;
   Birjand University of Medical Sciences
RP Samarghandian, S (corresponding author), Neyshabur Univ Med Sci, Hlth Ageing Res Ctr, Neyshabur, Iran.
EM samarghandians1@nums.ac.ir
RI Pourbagher-Shahri, Ali M./Y-5021-2018; Bernatoniene,
   Jurga/JUV-0714-2023; Farkhondeh, Tahereh/Y-2083-2018; Simal-Gandara,
   Jesus/A-9533-2009; Talebi, Marjan/AAS-8240-2020
OI Simal-Gandara, Jesus/0000-0001-9215-9737; Talebi,
   Marjan/0000-0001-5513-3204
CR Afrin S, 2020, NUTR RES REV, V33, P50, DOI 10.1017/S0954422419000192
   Ahmed OAA, 2020, EVID-BASED COMPL ALT, V2020, DOI 10.1155/2020/3439624
   Anandhi R, 2013, J PHYSIOL BIOCHEM, V69, P313, DOI 10.1007/s13105-012-0215-6
   Ancuceanu R, 2019, PHARMACEUTICS, V11, DOI 10.3390/pharmaceutics11080370
   Andrade N, 2019, FOOD FUNCT, V10, P4566, DOI [10.1039/c9fo01142k, 10.1039/C9FO01142K]
   Andrade N, 2020, EUR J NUTR, V59, P151, DOI 10.1007/s00394-019-01895-9
   Angelopoulou E, 2020, NEUROCHEM INT, V132, DOI 10.1016/j.neuint.2019.104612
   Anghel N, 2015, HISTOL HISTOPATHOL, V30, P1465, DOI 10.14670/HH-11-641
   Anitha T. A., 2014, Biomedicine & Preventive Nutrition, V4, P511
   Atanasov AG, 2021, NAT REV DRUG DISCOV, V20, P200, DOI 10.1038/s41573-020-00114-z
   Atrahimovich D, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10030423
   Begum S., 2020, ASIAN J CHEM, V32, P2105
   Cercato C, 2019, DIABETOL METAB SYNDR, V11, DOI 10.1186/s13098-019-0468-0
   Chatterjee A, 2012, CAN FAM PHYSICIAN, V58, P389
   Chen Q, 2020, CURR PHARM DESIGN, V26, P160, DOI 10.2174/1381612825666191216124310
   Chen S., 2020, Curr. Pharmacol. Rep, V6, P1, DOI [10.1007/s40495-020-00240-7, DOI 10.1007/S40495-020-00240-7]
   Choi JH, 2016, NUTRITION, V32, P1002, DOI 10.1016/j.nut.2016.02.007
   de Zeeuw D, 2008, NAT CLIN PRACT CARD, V5, pS10, DOI 10.1038/ncpcardio1271
   Dinda B, 2015, J ETHNOPHARMACOL, V161, P255, DOI 10.1016/j.jep.2014.12.027
   Eckel RH, 2010, LANCET, V375, P181, DOI 10.1016/S0140-6736(09)61794-3
   El-Bassossy HM, 2013, PHYTOTHER RES, V27, P1678, DOI 10.1002/ptr.4917
   Farkhondeh T, 2020, MOLECULES, V25, DOI 10.3390/molecules25215218
   Farkhondeh T, 2020, BIOMED PHARMACOTHER, V127, DOI 10.1016/j.biopha.2020.110234
   Farkhondeh T, 2019, J CELL PHYSIOL, V234, P16953, DOI 10.1002/jcp.28411
   Farkhondeh Tahereh, 2019, Cardiovascular & Hematological Agents in Medicinal Chemistry, V17, P17, DOI 10.2174/1871525717666190114145137
   Farkhondeh T, 2019, BIOMED PHARMACOTHER, V109, P1120, DOI 10.1016/j.biopha.2018.10.059
   Flordellis CS, 2005, TRENDS ENDOCRIN MET, V16, P254, DOI 10.1016/j.tem.2005.06.001
   Furlow B, 2013, LANCET DIABETES ENDO, V1, pS4, DOI 10.1016/S2213-8587(13)70128-1
   Ganai SA, 2021, PHYTOTHER RES, V35, P823, DOI 10.1002/ptr.6869
   Goldstein MR, 2010, LANCET ONCOL, V11, P415, DOI 10.1016/S1470-2045(10)70055-3
   Greenhill C, 2015, NAT REV ENDOCRINOL, P630
   Hashim KN, 2021, MOLECULES, V26, DOI 10.3390/molecules26040808
   Hjemdahl P, 2015, LANCET DIABETES ENDO, V3, P96, DOI 10.1016/S2213-8587(14)70072-5
   Huang PL, 2009, TRENDS ENDOCRIN MET, V20, P295, DOI 10.1016/j.tem.2009.03.005
   Idrus RBH, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17103613
   Ramírez-Espinosa JJ, 2018, MOLECULES, V23, DOI 10.3390/molecules23010067
   Kamat S, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-72497-3
   Khater M, 2019, FUTURE MED CHEM, V11, P2845, DOI 10.4155/fmc-2019-0237
   Khezri S, 2020, ENVIRON TOXICOL, V35, P1114, DOI 10.1002/tox.22947
   Kirk EP, 2009, J CLIN HYPERTENS, V11, P761, DOI 10.1111/j.1559-4572.2009.00054.x
   Kong MJ, 2021, BIOMED PHARMACOTHER, V133, DOI 10.1016/j.biopha.2020.110975
   Kopustinskiene DM, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020457
   Kurek-Górecka A, 2020, MOLECULES, V25, DOI 10.3390/molecules25030556
   Suraweera TL, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9100973
   Larit F, 2018, PHYTOCHEM LETT, V24, P1, DOI 10.1016/j.phytol.2017.12.012
   Li HB, 2019, PHARMACOL RES, V147, DOI 10.1016/j.phrs.2019.104393
   Li J, 2021, BIOMED PHARMACOTHER, V135, DOI 10.1016/j.biopha.2020.111167
   Lind L, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-82398-8
   Liu G, 2016, MOL NUTR FOOD RES, V60, P1984, DOI 10.1002/mnfr.201500801
   Liu YM, 2014, MED CHEM RES, V23, P555, DOI 10.1007/s00044-013-0711-4
   Lo HM, 2012, J NUTR BIOCHEM, V23, P667, DOI 10.1016/j.jnutbio.2011.03.011
   Mani R, 2018, PHYTOCHEMISTRY, V145, P187, DOI 10.1016/j.phytochem.2017.09.016
   Mantawy EM, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-05005-9
   Mantawy EM, 2014, EUR J PHARMACOL, V728, P107, DOI 10.1016/j.ejphar.2014.01.065
   Meckes M, 1998, PHYTOMEDICINE, V5, P459, DOI 10.1016/S0944-7113(98)80042-1
   Nagasaka M, 2018, MOLECULES, V23, DOI 10.3390/molecules23061394
   Olas B, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020283
   Pang XN, 2021, BIOMOLECULES, V11, DOI 10.3390/biom11020135
   Pingili RB, 2019, CHEM-BIOL INTERACT, V308, P51, DOI 10.1016/j.cbi.2019.05.010
   Pourbagher-Shahri AM, 2021, BIOMED PHARMACOTHER, V136, DOI 10.1016/j.biopha.2020.111214
   Rana AC, 2019, INDIAN J PHARM EDUC, V53, P8, DOI 10.5530/ijper.53.1.3
   Rani N, 2016, CHEM-BIOL INTERACT, V250, P59, DOI 10.1016/j.cbi.2016.03.015
   Rani N, 2015, NUTR METAB, V12, DOI 10.1186/s12986-015-0004-7
   Rauf A, 2015, FITOTERAPIA, V103, P129, DOI 10.1016/j.fitote.2015.03.019
   Roshanravan B, 2023, ARCH PHYSIOL BIOCHEM, V129, P393, DOI 10.1080/13813455.2020.1828482
   Saadawi S, 2012, MOLECULES, V17, P4824, DOI 10.3390/molecules17054824
   Salazar J, 2020, CURR PHARM DESIGN, V26, P4444, DOI 10.2174/1381612826666200701211422
   Samarghandian S, 2019, J CELL PHYSIOL, V234, P10421, DOI 10.1002/jcp.27710
   Samarghandian S, 2017, DOSE-RESPONSE, V15, DOI 10.1177/1559325817711782
   Samarghandian S, 2016, CAN J PHYSIOL PHARM, V94, P388, DOI 10.1139/cjpp-2014-0412
   Saponara S, 2021, EUR J PHARMACOL, V899, DOI 10.1016/j.ejphar.2021.174030
   Sawant O, 2020, DERMATOL THER, V33, DOI 10.1111/dth.13717
   Seetharaman P, 2017, ANN MICROBIOL, V67, P321, DOI 10.1007/s13213-017-1263-5
   Sharma P, 2019, NUTR NEUROSCI, V22, P569, DOI 10.1080/1028415X.2017.1418786
   Siedler M, 2020, BMJ OPEN, V10, DOI 10.1136/bmjopen-2019-032656
   Sun AL, 2006, CHINESE J ANAL CHEM, V34, pS243
   Talebi M, 2021, EXPERT REV NEUROTHER, V21, P625, DOI 10.1080/14737175.2021.1923479
   Talebi M, 2021, CANCER CELL INT, V21, DOI 10.1186/s12935-021-01906-y
   Talebi M, 2021, PHYTOTHER RES, V35, P3078, DOI 10.1002/ptr.7033
   Talebi M, 2021, PHYTOTHER RES, V35, P1739, DOI 10.1002/ptr.6905
   Talebi Marjan, 2021, Current Drug Discovery Technologies, V18, pe28092020186381, DOI 10.2174/1570163817666200929114517
   Talebi M, 2020, BIOMED PHARMACOTHER, V130, DOI 10.1016/j.biopha.2020.110590
   Timpson NJ, 2005, LANCET, V366, P1954, DOI 10.1016/S0140-6736(05)67786-0
   Ullah A, 2020, MOLECULES, V25, DOI 10.3390/molecules25225243
   Veerappan R, 2019, INDIAN J CLIN BIOCHE, V34, P288, DOI 10.1007/s12291-018-0761-y
   Villar IC, 2005, PLANTA MED, V71, P829, DOI 10.1055/s-2005-871296
   Villas-Boas GR, 2021, PHARMACEUTICALS-BASE, V14, DOI 10.3390/ph14020148
   Viswanatha GL, 2021, ADV TRADIT MED, V21, P209, DOI 10.1007/s13596-020-00513-y
   Wang DD, 2020, J ETHNOPHARMACOL, V249, DOI 10.1016/j.jep.2019.112444
   Wang S, 2015, PHARM BIOL, V53, P1481, DOI 10.3109/13880209.2014.986688
   Williams CA, 1997, PHYTOCHEMISTRY, V46, P1349, DOI 10.1016/S0031-9422(97)00514-1
   Yamamoto Y, 2014, FOOD SCI TECHNOL RES, V20, P295, DOI 10.3136/fstr.20.295
   Yang M, 2018, J MOL HISTOL, V49, P555, DOI 10.1007/s10735-018-9793-0
   Ye QM, 2019, FRONT ONCOL, V9, DOI 10.3389/fonc.2019.00487
   Zarzecki MS, 2014, TOXICOL REP, V1, P200, DOI 10.1016/j.toxrep.2014.02.003
   Zeinali M, 2017, BIOMED PHARMACOTHER, V92, P998, DOI 10.1016/j.biopha.2017.06.003
   Zhang MR, 2020, NAT PROD RES, V34, P3335, DOI 10.1080/14786419.2019.1574786
   Zhang XJ, 2019, NUTR METAB, V16, DOI 10.1186/s12986-019-0370-7
   Zhao SN, 2019, J CARDIOVASC PHARM T, V24, P278, DOI 10.1177/1074248418810809
   Zhao TT, 2019, J PHARM PHARMACOL, V71, P1353, DOI 10.1111/jphp.13129
   Zhu Y, 2019, NAT PROD COMMUN, V14, DOI 10.1177/1934578X19878921
NR 101
TC 8
Z9 8
U1 0
U2 14
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-4501
EI 1873-5592
J9 CURR DRUG TARGETS
JI Curr. Drug Targets
PY 2022
VL 23
IS 5
BP 458
EP 470
DI 10.2174/1389450122666211005113234
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 2U8SJ
UT WOS:000823424300004
PM 34636295
DA 2025-06-11
ER

PT J
AU Azar, RR
   Sarkis, A
   Salameh, E
   Gannagé-Yared, MH
   Amm-Azar, M
   Badaoui, G
   Germanos, M
   Kassab, R
AF Azar, Rabih R.
   Sarkis, Antoine
   Salameh, Elie
   Gannage-Yared, Marie-Helene
   Amm-Azar, Mireille
   Badaoui, Georges
   Germanos, Mirna
   Kassab, Roland
TI Percutaneous coronary intervention increases leptin and decreases
   adiponectin levels
SO CLINICAL ENDOCRINOLOGY
LA English
DT Article
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; ADIPOSE-TISSUE; OXIDATIVE STRESS; OBESITY; RISK;
   INTERLEUKIN-6; ASSOCIATION
AB Objective The study was designed to examine the effect of percutaneous coronary intervention (PCI) on adiponectin and leptin levels. We have previously demonstrated that PCI triggers a systemic inflammatory response. We hypothesized that inflammation participates in the pathogenesis of diabetes mellitus and the metabolic syndrome by modulating levels of adiponectin and leptin.
   Design Prospective study in which inflammation was induced by PCI.
   Patients Forty-eight patients with stable coronary artery disease and without diabetes mellitus.
   Measurements High-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), leptin and adiponectin were measured at baseline and 48 h after the procedure.
   Results Following PCI, hs-CRP increased by 211%, IL-6 by 87% and leptin by 19%, while adiponectin decreased by 14% (P < 0.001 for all). The change in IL-6 correlated with that in hs-CRP (rho = 0.32; P = 0.027), as did the changes in IL-6 and leptin (rho = 0.31; P = 0.03). The change in adiponectin, however, did not correlate with the change in any of the other markers.
   Conclusion This study demonstrates that PCI affects the levels of adiponectin and leptin within 48 h. These effects may be secondary to the inflammatory response triggered by PCI.
C1 Hotel Dieu France Hosp, Div Cardiol, Beirut, Lebanon.
   Hotel Dieu France Hosp, Div Endocrinol, Beirut, Lebanon.
   Hotel Dieu France Hosp, Immunol Lab, Beirut, Lebanon.
   St Joseph Univ Sch Med, Beirut, Lebanon.
RP Azar, RR (corresponding author), Hotel Dieu France Hosp, Div Cardiol, Beirut, Lebanon.
EM razar@usj.edu.lb
RI Azar, Rabih/V-8962-2019
OI Holy Spirit University of Kaslik (USEK), FACULTY OF MEDICINE AND MEDICAL
   SCIENCESHoly Spirit University of Kaslik (USEK)/0000-0001-6734-4105;
   Gannage-Yared, Marie-Helene/0000-0001-8780-1254
CR Azar RR, 1997, AM J CARDIOL, V80, P1476, DOI 10.1016/S0002-9149(97)00726-1
   Azar RR, 2005, AM J CARDIOL, V95, P236, DOI 10.1016/j.amjcard.2004.08.093
   Bastard JP, 1999, CIRCULATION, V99, P2221
   Baumann H, 1996, P NATL ACAD SCI USA, V93, P8374, DOI 10.1073/pnas.93.16.8374
   Berg K, 2004, FREE RADICAL RES, V38, P517, DOI 10.1080/10715760410001688339
   Bistrian BR, 2000, JAMA-J AM MED ASSOC, V283, P2235
   Bruun JM, 2003, AM J PHYSIOL-ENDOC M, V285, pE527, DOI 10.1152/ajpendo.00110.2003
   Díez JJ, 2003, EUR J ENDOCRINOL, V148, P293, DOI 10.1530/eje.0.1480293
   Fasshauer M, 2003, BIOCHEM BIOPH RES CO, V301, P1045, DOI 10.1016/S0006-291X(03)00090-1
   Flegal KM, 2002, JAMA-J AM MED ASSOC, V288, P1723, DOI 10.1001/jama.288.14.1723
   Ghanim H, 2004, CIRCULATION, V110, P1564, DOI 10.1161/01.CIR.0000142055.53122.FA
   Goldstein BJ, 2004, J CLIN ENDOCR METAB, V89, P2563, DOI 10.1210/jc.2004-0518
   Han TS, 2002, DIABETES CARE, V25, P2016, DOI 10.2337/diacare.25.11.2016
   Helmersson J, 2004, CIRCULATION, V109, P1729, DOI 10.1161/01.CIR.0000124718.99562.91
   Hu FB, 2004, DIABETES, V53, P693, DOI 10.2337/diabetes.53.3.693
   Kahn BB, 2000, J CLIN INVEST, V106, P473, DOI 10.1172/JCI10842
   Kershaw EE, 2004, J CLIN ENDOCR METAB, V89, P2548, DOI 10.1210/jc.2004-0395
   Konstantinides S, 2001, J CLIN INVEST, V108, P1533, DOI 10.1172/JCI13143
   Kumada M, 2004, CIRCULATION, V109, P2046, DOI 10.1161/01.CIR.0000127953.98131.ED
   Kumada M, 2003, ARTERIOSCL THROM VAS, V23, P85, DOI 10.1161/01.ATV.0000048856.22331.50
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Leyva F, 1998, ARTERIOSCL THROM VAS, V18, P928, DOI 10.1161/01.ATV.18.6.928
   Loffreda S, 1998, FASEB J, V12, P57, DOI 10.1096/fasebj.12.1.57
   Maison P, 2001, DIABETES CARE, V24, P1758, DOI 10.2337/diacare.24.10.1758
   Mohamed-Ali V, 1997, J CLIN ENDOCR METAB, V82, P4196, DOI 10.1210/jc.82.12.4196
   Ouchi N, 1999, CIRCULATION, V100, P2473, DOI 10.1161/01.CIR.100.25.2473
   Pischon T, 2004, JAMA-J AM MED ASSOC, V291, P1730, DOI 10.1001/jama.291.14.1730
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Ridker PM, 1997, NEW ENGL J MED, V336, P973, DOI 10.1056/NEJM199704033361401
   Rutter MK, 2004, CIRCULATION, V110, P380, DOI 10.1161/01.CIR.0000136581.59584.0E
   Sader S, 2003, CIRCULATION, V108, P644, DOI 10.1161/01.CIR.0000081427.01306.7D
   Sattar N, 2003, CIRCULATION, V108, P414, DOI 10.1161/01.CIR.0000080897.52664.94
   Schäfer K, 2004, ARTERIOSCL THROM VAS, V24, P112, DOI 10.1161/01.ATV.0000105904.02142.e7
   Senn JJ, 2003, J BIOL CHEM, V278, P13740, DOI 10.1074/jbc.M210689200
   Shek EW, 1998, HYPERTENSION, V31, P409, DOI 10.1161/01.HYP.31.1.409
   Vivekananthan DP, 2004, AM J CARDIOL, V94, P358, DOI 10.1016/j.amjcard.2004.04.035
   Wallace AM, 2001, CIRCULATION, V104, P3052, DOI 10.1161/hc5001.101061
   Weyer C, 2001, J CLIN ENDOCR METAB, V86, P1930, DOI 10.1210/jc.86.5.1930
   Yudkin JS, 1999, ARTERIOSCL THROM VAS, V19, P972, DOI 10.1161/01.ATV.19.4.972
NR 39
TC 8
Z9 11
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD DEC
PY 2006
VL 65
IS 6
BP 712
EP 716
DI 10.1111/j.1365-2265.2006.02654.x
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 106OW
UT WOS:000242111400003
PM 17121520
DA 2025-06-11
ER

PT J
AU Na, GY
   Yoon, SR
   An, J
   Yeo, R
   Song, J
   Jo, MN
   Han, S
   Kim, OY
AF Na, Ga Yoon
   Yoon, So Ra
   An, Juhyun
   Yeo, Rimkyo
   Song, Juhyun
   Jo, Mi-Na
   Han, Seongho
   Kim, Oh Yoen
TI The relationship between circulating neutrophil gelatinase-associated
   lipocalin and early alteration of metabolic parameters is associated
   with dietary saturated fat intake in non- diabetic Korean women
SO ENDOCRINE JOURNAL
LA English
DT Article
DE Neutrophil gelatinase; associated lipocalin; Metabolic syndrome;
   Saturated fat intake; Inflammation; Oxidative stress
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE;
   GENE-EXPRESSION; IMMUNE-RESPONSE; INFLAMMATION; OBESITY; ENDOTOXEMIA;
   PROTEIN; MECHANISM
AB Circulating neutrophil gelatinase-associated lipocalin (NGAL) is associated with obesity-related metabolic disorders. This study investigated the relationship between serum NGAL and early alteration of metabolic parameters in non-diabetic Korean women, particularly with respect to saturated fat (SFA) intake. Anthropometric parameters, fasting glycemic status, and levels of lipids, oxidative stress/inflammatory markers, and NGAL were measured in 82 non-diabetic Korean women [Super-healthy group (n=57) with 0 metabolic syndrome risk factor (MetS RF) and MetS-risk group (n=25) with MetS RF >= 1]. Age, weight, waist circumference, blood pressure, fasting glucose, HbA1C, triglyceride, LDL and total-cholesterol, and NGAL levels were higher, and HDL-cholesterol was lower in the MetS-risk group than in the Super-healthy group. Age-adjusted serum NGAL levels were higher in the MetS-risk group than in the Super-healthy group. NGAL increased proportionally with increase in MetS RFs (p=0.038) and correlated positively with BMI, triglycerides, LDL-and total-cholesterol, interleukin-6, white blood cell count, and neutrophil%, and negatively with HDL-cholesterol and superoxide dismutase activity. Serum NGAL levels positively correlated with SFA intake before and after adjustment (age and BMI). Serum NGAL levels were higher in high-SFA consumers [>= 7g/day, >= 7% of total calorie intake (TCI)] than in low-SFA consumers (< 7g/day, < 7% of TCI). Serum NGAL levels were highest in the MetS-risk group consuming higher SFA and lowest in the Super-healthy group consuming lower SFA. However, serum NGAL did not significantly differ between the low-SFA consuming MetS-risk and Super-healthy groups. The relationship between circulating NGAL and early alteration of metabolic parameters is associated with dietary SFA intake in non-diabetic Korean women.
C1 [Na, Ga Yoon; Yoon, So Ra; An, Juhyun; Yeo, Rimkyo; Kim, Oh Yoen] Dong A Univ, Dept Food Sci & Nutr, Brain Busan Project 21, Busan 49315, South Korea.
   [Song, Juhyun] Chonnam Natl Univ, Ctr Creat Biomed Scientists, Dept Biomed Sci, Gwangju 61469, South Korea.
   [Jo, Mi-Na] Univ Suwon, Div Hotel & Tourism, Coll Econ & Business Adm, Suwon 18323, South Korea.
   [Han, Seongho] Dong A Univ, Coll Med, Dept Family Med, Busan 49315, South Korea.
C3 Dong A University; Chonnam National University; Suwon University; Dong A
   University
RP Kim, OY (corresponding author), Dong A Univ, Dept Food Sci & Nutr, 550beon Gil Hadan Dong 37, Busan 49315, South Korea.
EM oykim@dau.ac.kr
RI Song, Juhyun/AAH-3162-2020; Kim, Oh/AAA-6492-2022
OI Han, Seongho/0000-0002-6983-8683; Song, Juhyun/0000-0002-9165-8507
FU National Research Foundation of Korea - Korean Government
   [2016R1A2B4013627]
FX This study was supported by the National Research Foundation of Korea
   Grant funded by the Korean Government (2016R1A2B4013627).
CR Aigner F, 2007, AM J TRANSPLANT, V7, P779, DOI 10.1111/j.1600-6143.2006.01723.x
   Barzilay JI, 2001, DIABETES, V50, P2384, DOI 10.2337/diabetes.50.10.2384
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Chae JS, 2011, ATHEROSCLEROSIS, V218, P499, DOI 10.1016/j.atherosclerosis.2011.06.036
   CHRISTIAN JL, 1994, NUTR LIVING, P111
   Dent CL, 2007, CRIT CARE, V11, DOI 10.1186/cc6192
   Devireddy LR, 2001, SCIENCE, V293, P829, DOI 10.1126/science.1061075
   Dinh QN, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/406960
   Erridge C, 2007, AM J CLIN NUTR, V86, P1286, DOI 10.1093/ajcn/86.5.1286
   Fernández-Real JM, 2006, DIABETES CARE, V29, P1058, DOI 10.2337/dc05-2068
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Flo TH, 2004, NATURE, V432, P917, DOI 10.1038/nature03104
   Flower DR, 2000, BBA-PROTEIN STRUCT M, V1482, P9, DOI 10.1016/S0167-4838(00)00148-5
   Fujino RS, 2006, MOL ENDOCRINOL, V20, P904, DOI 10.1210/me.2005-0423
   GarayRojas E, 1996, GENE, V170, P173, DOI 10.1016/0378-1119(95)00896-9
   Han TS, 2002, DIABETES CARE, V25, P2016, DOI 10.2337/diacare.25.11.2016
   Hossain P, 2007, NEW ENGL J MED, V356, P213, DOI 10.1056/NEJMp068177
   Huang HL, 1999, J ENDOCRINOL, V162, P11, DOI 10.1677/joe.0.1620011
   Huang Y, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-11
   KJELDSEN L, 1994, BLOOD, V83, P799
   Krogh-Madsen R, 2008, AM J PHYSIOL-ENDOC M, V294, pE371, DOI 10.1152/ajpendo.00507.2007
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Law IKM, 2010, DIABETES, V59, P872, DOI 10.2337/db09-1541
   Lee JY, 2006, MOL CELLS, V21, P174
   Matsuda M, 2013, OBES RES CLIN PRACT, V7, pE330, DOI 10.1016/j.orcp.2013.05.004
   McNeill AM, 2005, DIABETES CARE, V28, P385, DOI 10.2337/diacare.28.2.385
   Mello MM, 2006, NEW ENGL J MED, V354, P2601, DOI 10.1056/NEJMhpr060227
   Ministry of Health and Welfare: Korea Centers for Disease Control and Prevention, 2014, KOR HLTH STAT 2013 K
   Mishra J, 2005, LANCET, V365, P1231, DOI 10.1016/s0140-6736(05)74811-x
   Mohanty P, 2002, AM J CLIN NUTR, V75, P767, DOI 10.1093/ajcn/75.4.767
   Moreno-Navarrete JM, 2010, INT J OBESITY, V34, P240, DOI 10.1038/ijo.2009.242
   Mori K, 2007, KIDNEY INT, V71, P967, DOI 10.1038/sj.ki.5002165
   Ni J, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-176
   Pan HZ, 2010, ACTA DIABETOL, V47, pS71, DOI 10.1007/s00592-009-0128-1
   Roudkenar MH, 2007, J RADIAT RES, V48, P39, DOI 10.1269/jrr.06057
   Schmidt-Ott KM, 2007, J AM SOC NEPHROL, V18, P407, DOI 10.1681/ASN.2006080882
   Shoelson SE, 2007, GASTROENTEROLOGY, V132, P2169, DOI 10.1053/j.gastro.2007.03.059
   Song MJ, 2006, BIOCHEM BIOPH RES CO, V346, P739, DOI 10.1016/j.bbrc.2006.05.170
   The American Dietetic Association, 1992, AM DIET ASS HDB CLIN, P5
   Tripathy D, 2003, DIABETES, V52, P2882, DOI 10.2337/diabetes.52.12.2882
   Wang Y, 2007, CLIN CHEM, V53, P34, DOI [10.1373/clinchem.2006.075614, 10.1007/s11461-007-0005-4]
   Wu GY, 2014, ARTERIOSCL THROM VAS, V34, P2457, DOI 10.1161/ATVBAHA.114.303718
   Yan QW, 2007, DIABETES, V56, P2533, DOI 10.2337/db07-0007
   Zhang JH, 2008, MOL ENDOCRINOL, V22, P1416, DOI 10.1210/me.2007-0420
NR 45
TC 14
Z9 16
U1 0
U2 5
PU JAPAN ENDOCRINE SOC
PI KYOTO
PA 75  YANAGINOBANBA NISHIIRU-MASUYA-CHO, SANJOU-DORI, NAKAGYOU-KU, KYOTO,
   604-8111, JAPAN
SN 0918-8959
EI 1348-4540
J9 ENDOCR J
JI Endocr. J.
PY 2017
VL 64
IS 3
BP 303
EP 314
DI 10.1507/endocrj.EJ16-0233
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ER1TK
UT WOS:000398576500007
PM 28049882
OA gold
DA 2025-06-11
ER

PT J
AU Risérus, U
   Sprecher, D
   Johnson, T
   Olson, E
   Hirschberg, S
   Liu, A
   Fang, Z
   Hegde, P
   Richards, D
   Sarov-Blat, L
   Strum, JC
   Basu, S
   Cheeseman, J
   Fielding, BA
   Humphreys, SM
   Danoff, T
   Moore, NR
   Murgatroyd, P
   O'Rahilly, S
   Sutton, P
   Willson, T
   Hassall, D
   Frayn, KN
   Karpe, F
AF Riserus, Ulf
   Sprecher, Dennis
   Johnson, Tony
   Olson, Eric
   Hirschberg, Sandra
   Liu, Aixue
   Fang, Zeke
   Hegde, Priti
   Richards, Duncan
   Sarov-Blat, Leli
   Strum, Jay C.
   Basu, Samar
   Cheeseman, Jane
   Fielding, Barbara A.
   Humphreys, Sandy M.
   Danoff, Theodore
   Moore, Niall R.
   Murgatroyd, Peter
   O'Rahilly, Stephen
   Sutton, Pauline
   Willson, Tim
   Hassall, David
   Frayn, Keith N.
   Karpe, Fredrik
TI Activation of peroxisome proliferator-activated receptor (PPAR)δ
   promotes reversal of multiple metabolic abnormalities, reduces oxidative
   stress, and increases fatly acid oxidation in moderately obese men
SO DIABETES
LA English
DT Article
ID C-III EXPRESSION; SKELETAL-MUSCLE; INSULIN-RESISTANCE; FATTY-ACID;
   ADIPOSE-TISSUE; LIVER FAT; HYPOLIPIDEMIC ACTION; BEZAFIBRATE THERAPY;
   LIPOPROTEIN-LIPASE; DIABETES-MELLITUS
AB OBJECTIEVE-Pharmacological use of peroxisome proliferator-activated receptor (PPAR)delta agonists and transgenic overexpression of PPAR delta in mice suggest amelioration of features of the metabolic syndrome through enhanced fat oxidation in skeletal muscle. We hypothesize a similar mechanism operates in humans.
   RESEARCH DESIGN AND METHODS-The PPAR delta agonist (10 mg o.d. GW501516), a comparator PPAR alpha agonist (20 mu g o.d. GW590735)), and placebo were given in a double-blind, randomized, three-parallel group, 2-week study to six healthy moderately overweight subjects in each group. Metabolic evaluation was made before and after treatment including liver fat quantification, fasting blood samples, a 6-h meal tolerance test with stable isotope fatty acids, skeletal muscle biopsy for gene expression, and urinary isoprostanes for global oxidative stress.
   RESULTS-Treatment with GW501516 showed statistically significant reductions in fasting plasma triglycerides (-30%), apolipoprotein B (-26%), LDL cholesterol (-23%), and insulin (-11%), whereas HDL cholesterol was unchanged. A 20% reduction in liver fat content (P < 0.05) and 30% reduction in urinary isoprostanes (P = 0.01) were also observed. Except for a lowering of triglycerides (-30%, P < 0.05), none of these changes were observed in response to GW590735. The relative proportion of exhaled CO, directly originating from the fat content of the meal was increased (P < 0.05) in response to GW501516, and skeletal muscle expression of carnitine palmitoyl-transferase 1b (CPT1b) was also significantly increased.
   CONCLUSIONS-The PPAR delta agonist GW501516 reverses multiple abnormalities associated with the metabolic syndrome without increasing oxidative stress. The effect is probably caused by increased fat oxidation in skeletal muscle.
C1 [Riserus, Ulf; Cheeseman, Jane; Fielding, Barbara A.; Humphreys, Sandy M.; Sutton, Pauline; Frayn, Keith N.; Karpe, Fredrik] Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.
   [Sprecher, Dennis; Johnson, Tony; Olson, Eric; Hirschberg, Sandra; Liu, Aixue; Fang, Zeke; Danoff, Theodore] GlaxoSmithKline, Cardiovasc & Urogenital Ctr Excellence Drug Disco, Human Target Validat, King Of Prussia, PA USA.
   [Hegde, Priti; Sarov-Blat, Leli; Strum, Jay C.] GlaxoSmithKline, CPDM CVU Unit, King Of Prussia, PA USA.
   [Richards, Duncan] GlaxoSmithKline, Addenbrookes Ctr Clin Invest ACCT Unit, Cambridge, England.
   [Basu, Samar] Uppsala Univ, Dept Publ Hlth, Uppsala, Sweden.
   [Moore, Niall R.] Univ Oxford, Churchill Hosp, Dept Radiol, Oxford, England.
   [Murgatroyd, Peter] Addenbrookes Hosp, Wellcome Trust Clin Res Facil, Cambridge, England.
   [O'Rahilly, Stephen] Univ Cambridge, Dept Clin Biochem & Med, Cambridge, England.
   [Willson, Tim] GlaxoSmithKline, Res Triangle Pk, NC USA.
   [Hassall, David] GlaxoSmithKline, Stevenage, Herts, England.
C3 University of Oxford; GlaxoSmithKline; Glaxosmithkline USA;
   GlaxoSmithKline; Glaxosmithkline USA; GlaxoSmithKline; Glaxosmithkline
   United Kingdom; Uppsala University; University of Oxford; University of
   Cambridge; Cambridge University Hospitals NHS Foundation Trust;
   Addenbrooke's Hospital; University of Cambridge; GlaxoSmithKline;
   Glaxosmithkline USA; GlaxoSmithKline; Glaxosmithkline United Kingdom
RP Karpe, F (corresponding author), Churchill Hosp, Oxford OX3 7LJ, England.
EM fredrik.kaipe@ocdem.ox.ac.uk
RI O'Rahilly, Stephen/ABF-6509-2020; feinstein, doug/M-9414-2019
OI Richards, Duncan/0000-0002-8093-7084; Willson,
   Timothy/0000-0003-4181-8223; Frayn, Keith/0000-0001-7281-1863; Karpe,
   Fredrik/0000-0002-2751-1770; o'rahilly, stephen/0000-0003-2199-4449;
   Fielding, Barbara/0000-0001-7887-809X
CR Adiels M, 2006, DIABETOLOGIA, V49, P755, DOI 10.1007/s00125-005-0125-z
   Bajaj M, 2003, DIABETES, V52, P1364, DOI 10.2337/diabetes.52.6.1364
   Basu S, 2004, FREE RADICAL RES, V38, P105, DOI 10.1080/10715760310001646895
   Basu S, 1998, PROSTAG LEUKOTR ESS, V58, P319, DOI 10.1016/S0952-3278(98)90042-4
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   de Man FHAF, 2000, ATHEROSCLEROSIS, V153, P363, DOI 10.1016/S0021-9150(00)00409-3
   Dressel U, 2003, MOL ENDOCRINOL, V17, P2477, DOI 10.1210/me.2003-0151
   Evans K, 2002, DIABETES, V51, P2684, DOI 10.2337/diabetes.51.9.2684
   FRANCESCHINI G, 1985, ARTERY, V12, P363
   Frayn KN, 2002, DIABETOLOGIA, V45, P1201, DOI 10.1007/s00125-002-0873-y
   Gerstein HC, 2006, LANCET, V368, P1096, DOI 10.1016/S0140-6736(06)69420-8
   Goodpaster BH, 2004, PEDIATR DIABETES, V5, P219, DOI 10.1111/j.1399-543X.2004.00071.x
   Hällsten K, 2002, DIABETES, V51, P3479, DOI 10.2337/diabetes.51.12.3479
   Haubenwallner S, 1995, J LIPID RES, V36, P2541
   HEIBRONN L, 2004, INT J OBES RELAT S4, V28, pS12
   KAHRI J, 1993, ATHEROSCLEROSIS, V102, P79, DOI 10.1016/0021-9150(93)90086-A
   Lambert DA, 1996, ATHEROSCLEROSIS, V127, P205, DOI 10.1016/S0021-9150(96)05955-2
   Lee CH, 2006, P NATL ACAD SCI USA, V103, P3444, DOI 10.1073/pnas.0511253103
   Maggs DG, 1998, ANN INTERN MED, V128, P176, DOI 10.7326/0003-4819-128-3-199802010-00002
   Marks SJ, 1997, INT J OBESITY, V21, P274, DOI 10.1038/sj.ijo.0800400
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   Mayerson AB, 2002, DIABETES, V51, P797, DOI 10.2337/diabetes.51.3.797
   Miyazaki Y, 2001, DIABETES CARE, V24, P710, DOI 10.2337/diacare.24.4.710
   Musiek ES, 2005, LIPIDS, V40, P987, DOI 10.1007/s11745-005-1460-7
   NIKKILA EA, 1977, METABOLISM, V26, P179, DOI 10.1016/0026-0495(77)90053-1
   NOLAN JJ, 1994, NEW ENGL J MED, V331, P1188, DOI 10.1056/NEJM199411033311803
   Oliver WR, 2001, P NATL ACAD SCI USA, V98, P5306, DOI 10.1073/pnas.091021198
   Perseghin G, 2005, CURR OPIN LIPIDOL, V16, P416, DOI 10.1097/01.mol.0000174401.07056.56
   Petersen KF, 2006, AM J MED, V119, p10S, DOI 10.1016/j.amjmed.2006.01.009
   SANE T, 1995, METABOLISM, V44, P589, DOI 10.1016/0026-0495(95)90115-9
   Sanyal AJ, 2005, NAT CLIN PRACT GASTR, V2, P46, DOI 10.1038/ncpgasthep0084
   SHEPHERD J, 1984, J CLIN INVEST, V74, P2164, DOI 10.1172/JCI111643
   Sierra ML, 2007, J MED CHEM, V50, P685, DOI 10.1021/jm058056x
   SIMO IE, 1993, ATHEROSCLEROSIS, V100, P55, DOI 10.1016/0021-9150(93)90067-5
   Sprecher DL, 2007, ARTERIOSCL THROM VAS, V27, P359, DOI 10.1161/01.ATV.0000252790.70572.0c
   STAELS B, 1995, J CLIN INVEST, V95, P705, DOI 10.1172/JCI117717
   Tan GD, 2005, DIABETOLOGIA, V48, P83, DOI 10.1007/s00125-004-1619-9
   Tanaka T, 2003, P NATL ACAD SCI USA, V100, P15924, DOI 10.1073/pnas.0306981100
   Terada S, 2006, AM J PHYSIOL-ENDOC M, V290, pE607, DOI 10.1152/ajpendo.00430.2005
   Tiikkainen M, 2004, DIABETES, V53, P2169, DOI 10.2337/diabetes.53.8.2169
   van der Veen JN, 2005, J LIPID RES, V46, P526, DOI 10.1194/jlr.M400400-JLR200
   Vega GL, 2003, CLIN PHARMACOL THER, V74, P236, DOI 10.1016/S0009-9236(03)00170-X
   VUDAC N, 1995, J CLIN INVEST, V96, P741, DOI 10.1172/JCI118118
   Wang YX, 2004, PLOS BIOL, V2, P1532, DOI 10.1371/journal.pbio.0020294
   Wang YX, 2003, CELL, V113, P159, DOI 10.1016/S0092-8674(03)00269-1
   WEISWEILER P, 1989, METABOLISM, V38, P271, DOI 10.1016/0026-0495(89)90086-3
   Yki-Jarvinen H, 2004, NEW ENGL J MED, V351, P1106, DOI 10.1056/NEJMra041001
   Yki-Järvinen H, 2005, ANN MED, V37, P347, DOI 10.1080/07853890510037383
NR 48
TC 271
Z9 317
U1 0
U2 17
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD FEB
PY 2008
VL 57
IS 2
BP 332
EP 339
DI 10.2337/db07-1318
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 259BP
UT WOS:000252914400007
PM 18024853
OA Bronze
DA 2025-06-11
ER

PT J
AU Tanaka, S
   Yamazaki, T
   Asano, S
   Mitsumoto, A
   Kobayashi, D
   Kudo, N
   Kawashima, Y
AF Tanaka, Shizuyo
   Yamazaki, Tohru
   Asano, Satoshi
   Mitsumoto, Atsushi
   Kobayashi, Daisuke
   Kudo, Naomi
   Kawashima, Yoichi
TI Increased Lipid Synthesis and Decreased β-Oxidation in the Liver of
   SHR/NDmcr-cp (cp/cp) Rats, an Animal Model of Metabolic
   Syndrome
SO LIPIDS
LA English
DT Article
DE Hepatic TAG accumulation; MUFA; De novo lipogenesis; beta-Oxidation;
   SHR/NDmcr-cp (cp/cp) rat
ID ENDOPLASMIC-RETICULUM STRESS; MONOUNSATURATED FATTY-ACIDS; HEPATIC
   STEATOSIS; TRIGLYCERIDE ACCUMULATION; TRANSCRIPTION FACTOR;
   INSULIN-RESISTANCE; UP-REGULATION; OBESE ZUCKER; ER STRESS; SREBP-1C
AB SHR/NDmcr-cp (cp/cp) rats (SHR/NDcp) are an animal model of metabolic syndrome. A previous study of ours revealed drastic increases in the mass of palmitic (16:0), oleic (18:1n-9), palmitoleic (16:1n-7), cis-vaccenic (18:1n-7) and 5,8,11-eicosatrienoic acids in the liver of SHR/NDcp. However, detailed information on the class of lipid accumulated and the mechanism responsible for the overproduction of the accumulated lipid in the liver was not obtained. This study aimed to characterize the class of lipid accumulated and to explore the mechanism underlying the lipid accumulation in the liver of SHR/NDcp, in comparison with SHR/NDmcr-cp (+/+) (lean hypertensive littermates of SHR/NDcp) and Wistar Kyoto rats. In the liver of SHR/NDcp, de novo synthesis of fatty acids (16:0, 18:1n-9 and 16:1n-7) and triacylglycerol (TAG) synthesis were up-regulated and fatty acid beta-oxidation was down-regulated. These perturbations of lipid metabolism caused fat accumulation in hepatocytes and accumulation of TAG, which were enriched with 16:0, 18:1n-9 and 16:1n-7, in the liver of SHR/NDcp. On the other hand, no changes were found in hepatic contents of diacylglycerol and unesterified fatty acid (FFA); among FFA, there were no differences in the hepatic concentrations of unesterified 16:0 and stearic acid between SHR/NDcp and two other groups of rats. Moreover, little change was brought about in the expression of genes responsive to endoplasmic reticulum stress in the liver of SHR/NDcp. These results may reinforce the pathophysiological role of stearoyl-CoA desaturase 1 and fatty acid elongase 6 in the liver of SHR/NDcp.
C1 [Tanaka, Shizuyo; Yamazaki, Tohru; Kobayashi, Daisuke; Kudo, Naomi; Kawashima, Yoichi] Josai Univ, Fac Pharmaceut Sci, Sakado, Saitama 3500295, Japan.
   [Asano, Satoshi] Int Univ Hlth & Welf, Dept Pharmaceut Sci, Ohtawara, Tochigi 3248501, Japan.
   [Mitsumoto, Atsushi] Josai Int Univ, Fac Pharmaceut Sci, Togane, Chiba 2838555, Japan.
C3 Josai University; International University of Health & Welfare
RP Kawashima, Y (corresponding author), Josai Univ, Fac Pharmaceut Sci, 1-1 Keyakidai, Sakado, Saitama 3500295, Japan.
EM ykawash@josai.ac.jp
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
FX We thank Chiho Kojiguchi for her very helpful technical assistance. This
   work was supported by a Grant-in-Aid for Scientific Research from the
   Ministry of Education, Culture, Sports, Science and Technology of Japan.
CR Akazawa Y, 2010, J HEPATOL, V52, P586, DOI 10.1016/j.jhep.2010.01.003
   Araya J, 2010, OBESITY, V18, P1460, DOI 10.1038/oby.2009.379
   BELL RM, 1976, ANAL BIOCHEM, V71, P436, DOI 10.1016/S0003-2697(76)80009-7
   Benhamed F, 2012, J CLIN INVEST, V122, P2176, DOI 10.1172/JCI41636
   Bjermo H, 2010, CURR OPIN CLIN NUTR, V13, P703, DOI 10.1097/MCO.0b013e32833ec41b
   BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911
   Cha JY, 2007, J BIOL CHEM, V282, P743, DOI 10.1074/jbc.M605023200
   Delgado TC, 2009, NMR BIOMED, V22, P310, DOI 10.1002/nbm.1327
   Diraison F, 2002, AM J PHYSIOL-ENDOC M, V282, pE46, DOI 10.1152/ajpendo.2002.282.1.E46
   Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI23621
   Elam MB, 2001, J LIPID RES, V42, P2039
   Elizondo A, 2007, OBESITY, V15, P24, DOI 10.1038/oby.2007.518
   Ferré P, 2007, HORM RES, V68, P72, DOI 10.1159/000100426
   Flowers MT, 2006, J LIPID RES, V47, P2668, DOI 10.1194/jlr.M600203-JLR200
   Friedman MI, 1999, AM J PHYSIOL-REG I, V276, pR1046, DOI 10.1152/ajpregu.1999.276.4.R1046
   Fu SN, 2011, NATURE, V473, P528, DOI 10.1038/nature09968
   Glatz JFC, 2010, PHYSIOL REV, V90, P367, DOI 10.1152/physrev.00003.2009
   Hammond LE, 2005, J BIOL CHEM, V280, P25629, DOI 10.1074/jbc.M503181200
   Hussein G, 2007, LIFE SCI, V80, P522, DOI 10.1016/j.lfs.2006.09.041
   Imai K, 1999, BIOCHEM PHARMACOL, V58, P925, DOI 10.1016/S0006-2952(99)00159-8
   IRITANI N, 1976, J BIOCHEM, V80, P217, DOI 10.1093/oxfordjournals.jbchem.a131267
   Issandou M, 2009, EUR J PHARMACOL, V618, P28, DOI 10.1016/j.ejphar.2009.07.004
   JAMDAR SC, 1995, BBA-LIPID LIPID MET, V1255, P237, DOI 10.1016/0005-2760(94)00217-M
   Jump DB, 2011, CURR OPIN CLIN NUTR, V14, P115, DOI 10.1097/MCO.0b013e328342991c
   Kammoun HL, 2009, J CLIN INVEST, V119, P1201, DOI 10.1172/JCI37007
   Karahashi M, 2013, LIPIDS, V48, P457, DOI 10.1007/s11745-013-3786-2
   Kawai K, 2012, EXP TOXICOL PATHOL, V64, P333, DOI 10.1016/j.etp.2010.09.006
   Keppler D., 1974, METHODS ENZYMATIC AN, V3, P1127, DOI DOI 10.1242/JEB.037275
   Kohjima M, 2008, INT J MOL MED, V21, P507
   KOLETSKY S, 1975, AM J PATHOL, V80, P129
   KOLETSKY S, 1973, EXP MOL PATHOL, V19, P53, DOI 10.1016/0014-4800(73)90040-3
   KRUMDIECK CL, 1980, ANAL BIOCHEM, V104, P118, DOI 10.1016/0003-2697(80)90284-5
   Lewis GF, 1997, CURR OPIN LIPIDOL, V8, P146, DOI 10.1097/00041433-199706000-00004
   Li ZZ, 2009, J BIOL CHEM, V284, P5637, DOI 10.1074/jbc.M807616200
   Listenberger LL, 2003, P NATL ACAD SCI USA, V100, P3077, DOI 10.1073/pnas.0630588100
   Liu Q, 2012, PROG LIPID RES, V51, P350, DOI 10.1016/j.plipres.2012.06.001
   LOWRY OH, 1951, J BIOL CHEM, V193, P265
   Man WC, 2006, J LIPID RES, V47, P1928, DOI 10.1194/jlr.M600172-JLR200
   Marchesini G, 2001, DIABETES, V50, P1844, DOI 10.2337/diabetes.50.8.1844
   Matsuzaka T, 2007, NAT MED, V13, P1193, DOI 10.1038/nm1662
   MICHAELIS OE, 1984, AM J CLIN NUTR, V39, P612, DOI 10.1093/ajcn/39.4.612
   Miyazaki M, 2001, J LIPID RES, V42, P1018
   Miyazaki M, 2007, CELL METAB, V6, P484, DOI 10.1016/j.cmet.2007.10.014
   Nepokroeff C.M., 1975, METHODS ENZYMOL, V35, P37, DOI [DOI 10.1016/0076-6879(75, 10.1016/0076-6879(75)35136-7]
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   OKAMOTO KOZO, 1963, JAPAN CIRCULATION JOUR, V27, P282
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Roden M, 2006, NAT CLIN PRACT ENDOC, V2, P335, DOI 10.1038/ncpendmet0190
   ROUSER G, 1966, LIPIDS, V1, P85, DOI 10.1007/BF02668129
   SHENG ZQ, 1995, P NATL ACAD SCI USA, V92, P935, DOI 10.1073/pnas.92.4.935
   Shimomura I, 2000, MOL CELL, V6, P77, DOI 10.1016/S1097-2765(00)00009-5
   Shimomura I, 1999, J BIOL CHEM, V274, P30028, DOI 10.1074/jbc.274.42.30028
   Stefan N, 2008, ENDOCR REV, V29, P939, DOI 10.1210/er.2008-0009
   Stefanovic-Racic M, 2008, AM J PHYSIOL-ENDOC M, V294, pE969, DOI 10.1152/ajpendo.00497.2007
   Takaya K, 1996, NAT GENET, V14, P130, DOI 10.1038/ng1096-130
   Tanaka S, 2012, BIOL PHARM BULL, V35, P184, DOI 10.1248/bpb.35.184
   TANAKA T, 1979, EUR J BIOCHEM, V98, P165, DOI 10.1111/j.1432-1033.1979.tb13173.x
   Targher G, 2007, DIABETIC MED, V24, P1, DOI 10.1111/j.1464-5491.2007.02025.x
   Trauner M, 2009, BIOCHIM BIOPHYS ACTA, V1801, P299
   Vial G, 2010, ACTA BIOCHIM POL, V57, P389
   Wang Y, 2006, J LIPID RES, V47, P2028, DOI 10.1194/jlr.M600177-JLR200
   Warensjö E, 2005, DIABETOLOGIA, V48, P1999, DOI 10.1007/s00125-005-1897-x
   Wei YR, 2006, AM J PHYSIOL-ENDOC M, V291, pE275, DOI 10.1152/ajpendo.00644.2005
   Wendel AA, 2009, BBA-MOL CELL BIOL L, V1791, P501, DOI 10.1016/j.bbalip.2008.10.010
   Wu JW, 2011, HEPATOLOGY, V54, P122, DOI 10.1002/hep.24338
   YAMADA K, 1978, ARCH BIOCHEM BIOPHYS, V190, P409, DOI 10.1016/0003-9861(78)90294-1
   Yamazaki T, 2012, BIOL PHARM BULL, V35, P1509, DOI 10.1248/bpb.b12-00243
   ZURKOWSK.P, 1964, CLIN CHEM, V10, P481
NR 68
TC 5
Z9 6
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0024-4201
EI 1558-9307
J9 LIPIDS
JI Lipids
PD NOV
PY 2013
VL 48
IS 11
BP 1115
EP 1134
DI 10.1007/s11745-013-3839-6
PG 20
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 239TD
UT WOS:000326047500006
PM 24045975
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Yagi, K
   Shimada, S
   Akiyama, Y
   Hatano, M
   Asano, D
   Ishikawa, Y
   Ueda, H
   Watanabe, S
   Akahoshi, K
   Ono, H
   Tanabe, M
   Tanaka, S
AF Yagi, Kohei
   Shimada, Shu
   Akiyama, Yoshimitsu
   Hatano, Megumi
   Asano, Daisuke
   Ishikawa, Yoshiya
   Ueda, Hiroki
   Watanabe, Shuichi
   Akahoshi, Keiichi
   Ono, Hiroaki
   Tanabe, Minoru
   Tanaka, Shinji
TI Loss of SFXN1 mitigates lipotoxicity and predicts poor outcome in
   non-viral hepatocellular carcinoma
SO SCIENTIFIC REPORTS
LA English
DT Article
ID STRESS
AB Hepatocellular carcinoma (HCC) imposes a huge global burden, arising from various etiological factors such as hepatitis virus infection and metabolic syndrome. While prophylactic vaccination and antiviral treatment have decreased the incidence of viral HCC, the growing prevalence of metabolic syndrome has led to an increase in non-viral HCC. To identify genes downregulated and specifically associated with unfavorable outcome in non-viral HCC cases, screening analysis was conducted using publically available transcriptome data. Among top 500 genes meeting the criteria, which were involved in lipid metabolism and mitochondrial function, a serine transporter located on inner mitochondrial membrane SFXN1 was highlighted. SFXN1 protein expression was significantly reduced in 33 of 105 HCC tissue samples, and correlated to recurrence-free and overall survival only in non-viral HCC. Human HCC cells with SFXN1 knockout (KO) displayed higher cell viability, lower fat intake and diminished reactive oxygen species (ROS) production in response to palmitate administration. In a subcutaneous transplantation mouse model, high-fat diet feeding attenuated tumorigenic potential in the control cells, but not in the SFXN1-KO cells. In summary, loss of SFXN1 expression suppresses lipid accumulation and ROS generation, preventing toxic effects from fat overload in non-viral HCC, and predicts clinical outcome of non-viral HCC patients.
C1 [Yagi, Kohei; Shimada, Shu; Akiyama, Yoshimitsu; Hatano, Megumi; Tanaka, Shinji] Tokyo Med & Dent Univ, Grad Sch Med, Dept Mol Oncol, 1-5-45 Yushima,Bunkyo Ku, Tokyo 1138519, Japan.
   [Yagi, Kohei; Asano, Daisuke; Ishikawa, Yoshiya; Ueda, Hiroki; Watanabe, Shuichi; Akahoshi, Keiichi; Ono, Hiroaki; Tanabe, Minoru; Tanaka, Shinji] Tokyo Med & Dent Univ, Grad Sch Med, Dept Hepatobiliary Pancreat Surg, Tokyo, Japan.
C3 Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU);
   Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU)
RP Shimada, S; Tanaka, S (corresponding author), Tokyo Med & Dent Univ, Grad Sch Med, Dept Mol Oncol, 1-5-45 Yushima,Bunkyo Ku, Tokyo 1138519, Japan.; Tanaka, S (corresponding author), Tokyo Med & Dent Univ, Grad Sch Med, Dept Hepatobiliary Pancreat Surg, Tokyo, Japan.
EM shimada.monc@tmd.ac.jp; tanaka.monc@tmd.ac.jp
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
   [19H01055, 22K08864, 20K21627, 22K19554]; P-CREATE [JP19cm0106540]; AMED
   (Japan Agency for Medical Research and Development) [JP23fk0210102,
   JP23fk0210090, JP23fk0210106, JP23fk0210136]; Princess Takamatsu Cancer
   Research Fund; Grants-in-Aid for Scientific Research [22K19554,
   23K27670] Funding Source: KAKEN
FX This work was supported by Grants-in-Aid for Scientific Research (A,
   19H01055; C, 22K08864) and Challenging Research (Exploratory, 20K21627
   and 22K19554) from the Ministry of Education, Culture, Sports, Science
   and Technology of Japan; P-CREATE (JP19cm0106540) and Program for Basic
   and Clinical Research on Hepatitis (JP23fk0210102, JP23fk0210090,
   JP23fk0210106 and JP23fk0210136) from AMED (Japan Agency for Medical
   Research and Development); Research Grant from the Princess Takamatsu
   Cancer Research Fund.
CR Acoba MG, 2021, CELL REP, V34, DOI 10.1016/j.celrep.2021.108869
   Aly HH, 2007, J HEPATOL, V46, P26, DOI 10.1016/j.jhep.2006.08.018
   Asakawa M, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-56039-0
   Bray F, 2018, CA-CANCER J CLIN, V68, P394, DOI [10.3322/caac.21492, 10.3322/caac.21609]
   Chang MH, 2016, GASTROENTEROLOGY, V151, P472, DOI 10.1053/j.gastro.2016.05.048
   Fitzmaurice C, 2019, JAMA ONCOL, V5, P1749, DOI 10.1001/jamaoncol.2019.2996
   Gorrini C, 2013, NAT REV DRUG DISCOV, V12, P931, DOI 10.1038/nrd4002
   Huang DW, 2007, GENOME BIOL, V8, DOI 10.1186/gb-2007-8-9-r183
   Kory N, 2018, SCIENCE, V362, P791, DOI 10.1126/science.aat9528
   Li DS, 2020, SIGNAL TRANSDUCT TAR, V5, DOI 10.1038/s41392-020-00216-5
   Li N, 2020, FREE RADICAL BIO MED, V160, P303, DOI 10.1016/j.freeradbiomed.2020.08.009
   Llovet JM, 2015, NAT REV CLIN ONCOL, V12, P408, DOI [10.1038/nrclinonc.2015.103, 10.1038/nrclinonc.2015.121]
   Muramatsu S, 2013, HEPATOLOGY, V58, P218, DOI 10.1002/hep.26345
   Nakagawa H, 2014, CANCER CELL, V26, P331, DOI 10.1016/j.ccr.2014.07.001
   Nakamura H, 2021, CANCER SCI, V112, P3945, DOI 10.1111/cas.15068
   Schönfeld P, 2008, FREE RADICAL BIO MED, V45, P231, DOI 10.1016/j.freeradbiomed.2008.04.029
   Serra D, 2013, ANTIOXID REDOX SIGN, V19, P269, DOI 10.1089/ars.2012.4875
   Shimada S, 2019, EBIOMEDICINE, V40, P457, DOI 10.1016/j.ebiom.2018.12.058
   Singal AG, 2020, J HEPATOL, V72, P250, DOI 10.1016/j.jhep.2019.08.025
   Srinivas US, 2019, REDOX BIOL, V25, DOI 10.1016/j.redox.2018.101084
   Tanaka S, 2011, HEPATOLOGY, V54, P1273, DOI 10.1002/hep.24536
   Yang JD, 2019, NAT REV GASTRO HEPAT, V16, P589, DOI 10.1038/s41575-019-0186-y
   Zhang ZY, 2021, NAT METAB, V3, P1608, DOI 10.1038/s42255-021-00487-4
   Zucman-Rossi J, 2015, GASTROENTEROLOGY, V149, P1226, DOI 10.1053/j.gastro.2015.05.061
NR 24
TC 5
Z9 5
U1 1
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 9
PY 2023
VL 13
IS 1
AR 9449
DI 10.1038/s41598-023-36660-w
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA J0OQ8
UT WOS:001006690200055
PM 37296228
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sabidó, E
   Wu, YB
   Bautista, L
   Porstmann, T
   Chang, CY
   Vitek, O
   Stoffel, M
   Aebersold, R
AF Sabido, Eduard
   Wu, Yibo
   Bautista, Lucia
   Porstmann, Thomas
   Chang, Ching-Yun
   Vitek, Olga
   Stoffel, Markus
   Aebersold, Ruedi
TI Targeted proteomics reveals strain-specific changes in the mouse insulin
   and central metabolic pathways after a sustained high-fat diet
SO MOLECULAR SYSTEMS BIOLOGY
LA English
DT Article
DE liver; metabolic syndrome; NAFLD; proteomics; SRM
ID NONALCOHOLIC STEATOHEPATITIS; LIVER-DISEASE; ENERGY-EXPENDITURE;
   MASS-SPECTROMETRY; OXIDATIVE STRESS; RESISTANCE; IDENTIFICATIONS;
   EXPRESSION; OBESITY
AB The metabolic syndrome is a collection of risk factors including obesity, insulin resistance and hepatic steatosis, which occur together and increase the risk of diseases such as diabetes, cardiovascular disease and cancer. In spite of intense research, the complex etiology of insulin resistance and its association with the accumulation of triacylglycerides in the liver and with hepatic steatosis remains not completely understood. Here, we performed quantitative measurements of 144 proteins involved in the insulin-signaling pathway and central metabolism in liver homogenates of two genetically well-defined mouse strains C57BL/6J and 129Sv that were subjected to a sustained high-fat diet. We used targeted mass spectrometry by selected reaction monitoring (SRM) to generate accurate and reproducible quantitation of the targeted proteins across 36 different samples (12 conditions and 3 biological replicates), generating one of the largest quantitative targeted proteomics data sets in mammalian tissues. Our results revealed rapid response to high-fat diet that diverged early in the feeding regimen, and evidenced a response to high-fat diet dominated by the activation of peroxisomal beta-oxidation in C57BL/6J and by lipogenesis in 129Sv mice.
C1 [Sabido, Eduard; Wu, Yibo; Bautista, Lucia; Porstmann, Thomas; Stoffel, Markus; Aebersold, Ruedi] ETH, Inst Mol Syst Biol, Dept Biol, CH-8093 Zurich, Switzerland.
   [Chang, Ching-Yun; Vitek, Olga] Purdue Univ, Dept Stat, W Lafayette, IN 47907 USA.
   [Vitek, Olga] Purdue Univ, Dept Comp Sci, W Lafayette, IN 47907 USA.
   [Aebersold, Ruedi] Univ Zurich, Fac Sci, Dept Sci, Zurich, Switzerland.
C3 Swiss Federal Institutes of Technology Domain; ETH Zurich; Purdue
   University System; Purdue University; Purdue University System; Purdue
   University; University of Zurich
RP Stoffel, M (corresponding author), ETH, Inst Mol Syst Biol, Dept Biol, Wolfgang Pauli Str 16, CH-8093 Zurich, Switzerland.
EM stoffel@imsb.biol.ethz.ch; aebersold@imsb.biol.ethz.ch
RI /AAK-8294-2020; Aebersold, Ruedi/ADH-8497-2022; Sabido,
   Eduard/F-7914-2015
OI Stoffel, Markus/0000-0003-1304-5817; Sabido, Eduard/0000-0001-6506-7714;
   Wu, Yibo/0000-0002-8256-3901
FU European Union via the ERC (European Research Council) [233226]; Swiss
   Initiative for Systems Biology (SystemsX); European Research Council
   (ERC) [233226] Funding Source: European Research Council (ERC); Div Of
   Biological Infrastructure; Direct For Biological Sciences [1054826]
   Funding Source: National Science Foundation
FX Support for this study was provided by the European Union via the ERC
   (European Research Council) advanced grant 'Proteomics v3.0' (grant#
   233226) to RA, and the LiverX program of the Swiss Initiative for
   Systems Biology (SystemsX) to ES, YWand LB.
CR Almind K, 2004, DIABETES, V53, P3274, DOI 10.2337/diabetes.53.12.3274
   [Anonymous], 2001, Generalized, Linear, and Mixed Models
   [Anonymous], MOL CELL PROTEOMICS, V7, P1489
   BENJAMINI Y, 1995, J R STAT SOC B, V57, P289, DOI 10.1111/j.2517-6161.1995.tb02031.x
   Bensimon A, 2012, ANNU REV BIOCHEM, V81, P379, DOI 10.1146/annurev-biochem-072909-100424
   Biddinger SB, 2005, DIABETES, V54, P1314, DOI 10.2337/diabetes.54.5.1314
   Cantó C, 2009, NATURE, V458, P1056, DOI 10.1038/nature07813
   Chang CY, 2012, MOL CELL PROTEOMICS, V11, DOI 10.1074/mcp.M111.014662
   Costenoble R, 2011, MOL SYST BIOL, V7, DOI 10.1038/msb.2010.122
   Dephoure N, 2012, SCI SIGNAL, V5, DOI 10.1126/scisignal.2002548
   Desiere F, 2006, NUCLEIC ACIDS RES, V34, pD655, DOI 10.1007/978-1-60761-444-9_19
   Dixon JB, 2001, GASTROENTEROLOGY, V121, P91, DOI 10.1053/gast.2001.25540
   Dixon JB, 2004, HEPATOLOGY, V39, P1647, DOI 10.1002/hep.20251
   Domon B, 2006, SCIENCE, V312, P212, DOI 10.1126/science.1124619
   Domon B, 2010, NAT BIOTECHNOL, V28, P710, DOI 10.1038/nbt.1661
   Eckel RH, 2010, LANCET, V375, P181, DOI 10.1016/S0140-6736(09)61794-3
   Elias JE, 2007, NAT METHODS, V4, P207, DOI 10.1038/nmeth1019
   Ideker T, 2001, SCIENCE, V292, P929, DOI 10.1126/science.292.5518.929
   Kirpich IA, 2011, J NUTR BIOCHEM, V22, P38, DOI 10.1016/j.jnutbio.2009.11.009
   Kulkarni RN, 2003, DIABETES, V52, P1528, DOI 10.2337/diabetes.52.6.1528
   Luyckx FH, 2000, DIABETES METAB, V26, P98
   Mallick P, 2007, NAT BIOTECHNOL, V25, P125, DOI 10.1038/nbt1275
   Marchesini G, 2001, DIABETES, V50, P1844, DOI 10.2337/diabetes.50.8.1844
   Martens L, 2005, PROTEOMICS, V5, P3537, DOI 10.1002/pmic.200401303
   Michalski A, 2011, J PROTEOME RES, V10, P1785, DOI 10.1021/pr101060v
   Pagano G, 2002, HEPATOLOGY, V35, P367, DOI 10.1053/jhep.2002.30690
   Park JY, 2004, PROTEOMICS, V4, P514, DOI 10.1002/pmic.200300623
   Picotti P, 2010, NAT METHODS, V7, P43, DOI [10.1038/NMETH.1408, 10.1038/nmeth.1408]
   Picotti P, 2009, CELL, V138, P795, DOI 10.1016/j.cell.2009.05.051
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Sabidó E, 2012, MOL CELL PROTEOMICS, V11, DOI 10.1074/mcp.M111.014746
   Schmid GM, 2004, PROTEOMICS, V4, P2270, DOI 10.1002/pmic.200300810
   Schwanhäusser B, 2011, NATURE, V473, P337, DOI 10.1038/nature10098
   Whaley-Connell A, 2011, REV CARDIOVASC MED, V12, P21, DOI 10.3909/ricm0555
   Zien A, 2001, Bioinformatics, V17 Suppl 1, pS323
NR 35
TC 28
Z9 31
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1744-4292
J9 MOL SYST BIOL
JI Mol. Syst. Biol.
PD JUL
PY 2013
VL 9
AR 681
DI 10.1038/msb.2013.36
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 195QB
UT WOS:000322717600002
PM 23860498
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Che, Y
   Wang, ZP
   Yuan, Y
   Zhang, N
   Jin, YG
   Wan, CX
   Tang, QZ
AF Che, Yan
   Wang, Zhao-Peng
   Yuan, Yuan
   Zhang, Ning
   Jin, Ya-Ge
   Wan, Chun-Xia
   Tang, Qi-Zhu
TI Role of autophagy in a model of obesity: A long-term high fat diet
   induces cardiac dysfunction
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE high-fat diet; cardiac dysfunction; endoplasmic reticulum stress;
   autophagy; mitophagy
ID ENDOPLASMIC-RETICULUM; INSULIN-RESISTANCE; SIGNALING PATHWAY; OXIDATIVE
   STRESS; CELLS; MICE; LIPOTOXICITY; MITOCHONDRIA; HYPERTROPHY; EXPRESSION
AB Obesity may induce end-organ damage through metabolic syndrome, and autophagy serves a vital role in the pathogenesis of metabolic syndrome. The purpose of the present study was to define the roles of autophagy and mitophagy in high fat diet (HFD)-induced cardiomyopathy. Male, 8 week-old C57BL/6 mice were fed either a HFD (60% kcal) or a diet of normal chow (NC; 10% kcal) for 42 weeks. Glucose tolerance tests were performed during the feeding regimes. Blood samples were collected for assaying serum triglyceride with the glycerol-3-phosphate oxidase phenol and aminophenazone (PAP) method and total cholesterol was tested with the cholesterol oxidase-PAP method. Myocardial function was assessed using echocardiography and hemodynamic analyses. Western blot analysis was employed to evaluate endoplasmic reticulum stress (ERS), autophagy and mitochondrial function. Electron microscopy was used to assess the number of lipid droplets and the degree of autophagy within the myocardium. The body weight and adipose tissue weight of mice fed the HFD were increased compared with the NC mice. The serum levels of blood glucose, total cholesterol and triglyceride were significantly increased following 42 weeks of HFD feeding. The results of the glucose tolerance tests additionally demonstrated metabolic dysregulation in HFD mice. In addition, HFD mice exhibited hemodynamic and echocardiographic evidence of impaired diastolic and systolic function, including alterations in the cardiac output, end-diastolic pressure, end-diastolic volume and left ventricular relaxation time constant (tau) following HFD intake. Furthermore, a HFD resulted in increased ERS, and a downregulation of the autophagy and mitophagy level. The present study investigated cardiac function in obese HFD-fed mice. These results aid the pursuit of novel therapeutic targets to combat obesity-associated cardiomyopathy.
C1 [Che, Yan; Wang, Zhao-Peng; Yuan, Yuan; Zhang, Ning; Jin, Ya-Ge; Wan, Chun-Xia; Tang, Qi-Zhu] Wuhan Univ, Renmin Hosp, Dept Cardiol, 238 Jiefang Rd, Wuhan 430060, Hubei, Peoples R China.
   [Che, Yan; Wang, Zhao-Peng; Yuan, Yuan; Zhang, Ning; Jin, Ya-Ge; Wan, Chun-Xia; Tang, Qi-Zhu] Wuhan Univ, Cardiovasc Res Inst, Wuhan 430060, Hubei, Peoples R China.
   [Che, Yan; Wang, Zhao-Peng; Yuan, Yuan; Zhang, Ning; Jin, Ya-Ge; Wan, Chun-Xia; Tang, Qi-Zhu] Hubei Key Lab Cardiol, Wuhan 430060, Hubei, Peoples R China.
C3 Wuhan University; Wuhan University
RP Tang, QZ (corresponding author), Wuhan Univ, Renmin Hosp, Dept Cardiol, 238 Jiefang Rd, Wuhan 430060, Hubei, Peoples R China.
EM qztang@whu.edu.cn
FU National Natural Science Foundation of China [81270303, 81470516,
   81530012]
FX The present study was supported by the National Natural Science
   Foundation of China (grant nos. 81270303, 81470516 and 81530012).
CR Adachi C, 2016, ASIA PAC J CLIN NUTR, V25, P478, DOI 10.6133/apjcn.092015.25
   Aroor AR, 2012, CARDIORENAL MED, V2, P87, DOI 10.1159/000335675
   Bernardini JP, 2017, ONCOGENE, V36, P1315, DOI 10.1038/onc.2016.302
   Billia F, 2011, P NATL ACAD SCI USA, V108, P9572, DOI 10.1073/pnas.1106291108
   Braun RJ, 2017, TRENDS CELL BIOL, V27, P441, DOI 10.1016/j.tcb.2017.02.007
   Calligaris SD, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0060931
   Canadian Council on Animal Care, 1993, GUIDE CARE USE EXPT, V1, P212
   Ceylan-Isik AF, 2013, J MOL CELL CARDIOL, V63, P4, DOI 10.1016/j.yjmcc.2013.07.002
   Contreras AV, 2013, ADV NUTR, V4, P439, DOI 10.3945/an.113.003798
   Cui MX, 2013, J DIABETES RES, V2013, DOI 10.1155/2013/852754
   De Lorenzo A, 2017, ACTA DIABETOL, V54, P141, DOI 10.1007/s00592-016-0917-2
   Deng X, 2017, RENAL FAILURE, V39, P306, DOI 10.1080/0886022X.2016.1274662
   Fang D, 2016, SCI REP-UK, V6, DOI 10.1038/srep31462
   Gomes LC, 2011, NAT CELL BIOL, V13, P589, DOI 10.1038/ncb2220
   Guan HP, 2017, EXP NEUROL, V291, P51, DOI 10.1016/j.expneurol.2017.02.001
   HAMM TE, 1995, CONTEMP TOP LAB ANIM, V34, P69
   Hanley AJG, 2000, AM J CLIN NUTR, V71, P693, DOI 10.1093/ajcn/71.3.693
   Hao T, 2017, INT J MOL MED, V39, P1029, DOI 10.3892/ijmm.2017.2910
   Hariharan N, 2011, ANTIOXID REDOX SIGN, V14, P2179, DOI 10.1089/ars.2010.3488
   Hashemzaei M, 2017, EUR J PHARMACOL, V802, P44, DOI 10.1016/j.ejphar.2017.02.038
   Hsu HC, 2016, EUR J NUTR, V55, P2245, DOI 10.1007/s00394-015-1034-7
   Komatsu M, 2006, NATURE, V441, P880, DOI 10.1038/nature04723
   Kong FJ, 2017, SCI REP-UK, V7, DOI 10.1038/srep44746
   Lewy TG, 2017, YALE J BIOL MED, V90, P291
   Li SJ, 2017, CLIN NUTR, V36, P760, DOI 10.1016/j.clnu.2016.06.002
   Liang XH, 1999, NATURE, V402, P672, DOI 10.1038/45257
   Marciniak SJ, 2004, GENE DEV, V18, P3066, DOI 10.1101/gad.1250704
   Mattson DL, 1998, AM J PHYSIOL-REG I, V274, pR564, DOI 10.1152/ajpregu.1998.274.2.R564
   Mu Y, 2017, SCI REP-UK, V7, DOI 10.1038/srep43475
   Pankiv S, 2007, J BIOL CHEM, V282, P24131, DOI 10.1074/jbc.M702824200
   Qin H, 2016, J CARDIOVASC PHARM, V68, P465, DOI 10.1097/FJC.0000000000000431
   Quan W, 2013, ARCH PHARM RES, V36, P223, DOI 10.1007/s12272-013-0024-7
   Rezabakhsh A, 2017, J CELL BIOCHEM, V118, P1518, DOI 10.1002/jcb.25814
   Rhee JS, 2016, HUM REPROD, V31, P1315, DOI 10.1093/humrep/dew048
   Rüb C, 2017, CELL TISSUE RES, V367, P111, DOI 10.1007/s00441-016-2485-8
   Sakamoto A, 2017, EXP CELL RES, V351, P109, DOI 10.1016/j.yexcr.2017.01.004
   Schell LM, 2012, AM J HUM BIOL, V24, P302, DOI 10.1002/ajhb.22257
   Sha HB, 2011, TRENDS ENDOCRIN MET, V22, P374, DOI 10.1016/j.tem.2011.05.002
   Shan B, 2017, NAT IMMUNOL, V18, P519, DOI 10.1038/ni.3709
   Starobinets H, 2016, J CLIN INVEST, V126, P4417, DOI 10.1172/JCI85705
   Takabatake Y, 2017, AUTOPHAGY, V13, P775, DOI 10.1080/15548627.2017.1283084
   van der Krieken SE, 2017, J CELL BIOCHEM, V118, P2161, DOI 10.1002/jcb.25858
   Vives-Bauza C, 2010, AUTOPHAGY, V6, P315, DOI 10.4161/auto.6.2.11199
   von Sarnowski B, 2013, STROKE, V44, P119, DOI 10.1161/STROKEAHA.112.665190
   Wang H, 2016, FASEB J, V30, P2549, DOI 10.1096/fj.201500119
   Wang Z, 2015, METABOLISM, V64, P917, DOI 10.1016/j.metabol.2015.04.010
   Wood-Kaczmar A, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0002455
   Wu JH, 2017, BIOCHEM BIOPH RES CO, V482, P678, DOI 10.1016/j.bbrc.2016.11.093
   Xu X, 2015, INT J OBESITY, V39, P387, DOI 10.1038/ijo.2014.174
   Xu XH, 2012, CLIN EXP PHARMACOL P, V39, P200, DOI 10.1111/j.1440-1681.2011.05638.x
   Zhang J, 2017, BIOCHEM BIOPH RES CO, V492, P520, DOI 10.1016/j.bbrc.2017.08.034
   Zhao CY, 2017, EXP CELL RES, V350, P390, DOI 10.1016/j.yexcr.2016.12.015
   Zhao D, 2017, INT J BIOL SCI, V13, P276, DOI 10.7150/ijbs.17617
   Zheng PF, 2017, SCI REP-UK, V7, DOI 10.1038/srep42574
NR 54
TC 30
Z9 31
U1 0
U2 15
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD SEP
PY 2018
VL 18
IS 3
BP 3251
EP 3261
DI 10.3892/mmr.2018.9301
PG 11
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA GR7RK
UT WOS:000442890400083
PM 30066870
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Hayden, MR
   Sowers, KM
   Pulakat, L
   Joginpally, T
   Krueger, B
   Whaley-Connell, A
   Sowers, JR
AF Hayden, Melvin R.
   Sowers, Kurt M.
   Pulakat, Lakshmi
   Joginpally, Tejaswini
   Krueger, Bennett
   Whaley-Connell, Adam
   Sowers, James R.
TI Possible Mechanisms of Local Tissue Renin-Angiotensin System Activation
   in the Cardiorenal Metabolic Syndrome and Type 2 Diabetes Mellitus
SO CARDIORENAL MEDICINE
LA English
DT Article
DE Adipose tissue; Insulin resistance; Mast cells; Reactive oxygen species;
   Redox stress; Renin-angiotensin system; Type 2 diabetes mellitus
ID OXIDATIVE STRESS; ADIPOSE-TISSUE; CONVERTING ENZYME; SKELETAL-MUSCLE;
   MAST-CELLS; BETA-CELL; HIP RAT; ALDOSTERONE SYSTEM; INSULIN-RESISTANCE;
   CHRONIC HYPOXIA
AB The role of local tissue renin-angiotensin system (tRAS) activation in the cardiorenal metabolic syndrome (CRS) and type 2 diabetes mellitus (T2DM) is not well understood. To this point, we posit that early redox stress-mediated injury to tissues and organs via accumulation of excessive reactive oxygen species (ROS) and associated wound healing responses might serve as a paradigm to better understand how tRAS is involved. There are at least five common categories responsible for generating ROS that may result in a positive feedback ROS-tRAS axis. These mechanisms include metabolic substrate excess, hormonal excess, hypoxia-ischemia/reperfusion, trauma, and inflammation. Because ROS are toxic to proteins, lipids, and nucleic acids they may be the primary instigator, serving as the injury nidus to initiate the wound healing process. Insulin resistance is central to the development of the CRS and T2DM, and there are now thought to be four major organ systems important in their development. In states of overnutrition and tRAS activation, adipose tissue, skeletal muscle (SkM), islet tissues, and liver (the quadrumvirate) are individually and synergistically related to the development of insulin resistance, CRS, and T2DM. The obesity epidemic is thought to be the driving force behind the CRS and T2DM, which results in the impairment of multiple end-organs, including the cardiovascular system, pancreas, kidney, retina, liver, adipose tissue, SkM, and nervous system. A better understanding of the complex mechanisms leading to local tRAS activation and increases in tissue ROS may lead to new therapies emphasizing global risk reduction of ROS resulting in decreased morbidity and mortality. Copyright (C) 2011 S. Karger AG, Basel
C1 [Hayden, Melvin R.; Pulakat, Lakshmi; Whaley-Connell, Adam; Sowers, James R.] Univ Missouri, Columbia Sch Med, Dept Internal Med, Columbia, MO 65211 USA.
   [Sowers, James R.] Univ Missouri, Columbia Sch Med, Dept Physiol & Pharmacol, Columbia, MO 65211 USA.
   [Hayden, Melvin R.; Pulakat, Lakshmi; Joginpally, Tejaswini; Krueger, Bennett; Whaley-Connell, Adam; Sowers, James R.] Diabetes Cardiovasc Ctr, Columbia, MO USA.
   [Pulakat, Lakshmi; Whaley-Connell, Adam; Sowers, James R.] Harry S Truman VA Med Ctr, Columbia, MO USA.
   [Sowers, Kurt M.] Kidney Specialists So Nevada, Henderson, NV USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital
RP Hayden, MR (corresponding author), D109 HSC Diabet Ctr, 1 Hosp Dr, Columbia, MO 65212 USA.
EM mrh29@usmo.com
FU NIH [R01 HL73101-01A1]; Veterans Affairs Merit System (NSF) [0018];
   Veterans Affairs Grants
FX This research was supported by NIH (R01 HL73101-01A1) and Veterans
   Affairs Merit System (0018; NSF LP) and Veterans Affairs Grants (J.R.S.
   and A.W.-C.).
CR Abdeen Mohammad Bosem, 2006, J Cardiometab Syndr, V1, P36, DOI 10.1111/j.0197-3118.2006.05523.x
   Agoudemos MM, 2005, MICROCIRCULATION, V12, P627, DOI 10.1080/10739680500301664
   BACHMANN S, 1992, KIDNEY INT, V41, P24, DOI 10.1038/ki.1992.4
   Basso N, 2001, HYPERTENSION, V38, P1246, DOI 10.1161/hy1201.101214
   Bergman RN, 2000, TRENDS ENDOCRIN MET, V11, P351, DOI 10.1016/S1043-2760(00)00323-4
   Brunswig-Spickenheier Baerbel, 2003, Indian Journal of Experimental Biology, V41, P669
   Butler AE, 2004, DIABETES, V53, P1509, DOI 10.2337/diabetes.53.6.1509
   CAMPBELL D J, 1987, Journal of Cardiovascular Pharmacology, V10, pS1
   Carey RM, 2003, ENDOCR REV, V24, P261, DOI 10.1210/er.2003-0001
   Célérier J, 2000, J BIOL CHEM, V275, P10648, DOI 10.1074/jbc.275.14.10648
   Chan WP, 2000, MOL CELL ENDOCRINOL, V160, P107
   CLARK RA, 1991, CHEST, V99, pS57, DOI 10.1378/chest.99.3_Supplement.57S
   CLARK RAF, 1985, J AM ACAD DERMATOL, V13, P701, DOI 10.1016/S0190-9622(85)70213-7
   Cooper ME, 2004, AM J HYPERTENS, V17, p16S, DOI 10.1016/j.amjhyper.2004.08.004
   Cortez-Pinto H, 2006, J HEPATOL, V44, P197, DOI 10.1016/j.jhep.2005.09.002
   Darimont C, 2008, INT J OBESITY, V32, P112, DOI 10.1038/sj.ijo.0803688
   De Nuccio I, 1999, Minerva Endocrinol, V24, P77
   DEFRONZO RA, 1985, J CLIN INVEST, V76, P149, DOI 10.1172/JCI111938
   DEFRONZO RA, 1988, DIABETES, V37, P667, DOI 10.2337/diab.37.6.667
   Dietze GJ, 2008, J RENIN-ANGIO-ALDO S, V9, P75, DOI 10.3317/jraas.2008.011
   Dostal DE, 2000, REGUL PEPTIDES, V91, P1, DOI 10.1016/S0167-0115(99)00123-8
   DZAU VJ, 1994, CIRCULATION, V89, P493, DOI 10.1161/01.CIR.89.1.493
   Dzau VJ, 1988, CIRCULATION, V77, P13
   Engeli S, 2000, HYPERTENSION, V35, P1270, DOI 10.1161/01.HYP.35.6.1270
   FAUST IM, 1978, AM J PHYSIOL, V235, pE279, DOI 10.1152/ajpendo.1978.235.3.E279
   GANTEN D, 1971, AM J PHYSIOL, V221, P1733, DOI 10.1152/ajplegacy.1971.221.6.1733
   Gilbert RE, 2003, DIABETIC MED, V20, P607, DOI 10.1046/j.1464-5491.2003.00979.x
   Glantzounis GK, 2001, SURG ENDOSC, V15, P1315, DOI 10.1007/s00464-001-0034-2
   Gloire G, 2006, BIOCHEM PHARMACOL, V72, P1493, DOI 10.1016/j.bcp.2006.04.011
   Goossens G H, 2003, Obes Rev, V4, P43
   Gorbunov NV, 1997, AM J PHYSIOL-LUNG C, V272, pL320, DOI 10.1152/ajplung.1997.272.2.L320
   Guo LP, 2004, HEPATOLOGY, V40, P583, DOI 10.1002/hep.20369
   Habibi J, 2008, ENDOCRINOLOGY, V149, P5643, DOI 10.1210/en.2008-0070
   Hayden MR, 2007, J PANCREAS, V8, P725
   Hayden MR, 2008, EXP BIOL MED, V233, P1109, DOI 10.3181/0709-RM-251
   Hayden Melvin R, 2006, J Cardiometab Syndr, V1, P326, DOI 10.1111/j.1559-4564.2006.05626.x
   Hayden Melvin R, 2007, J Cardiometab Syndr, V2, P70, DOI 10.1111/j.1559-4564.2007.06159.x
   Hayden MR, 2007, ANTIOXID REDOX SIGN, V9, P891, DOI 10.1089/ars.2007.1610
   Hayden MR, 2007, AM J PHYSIOL-RENAL, V292, pF861, DOI 10.1152/ajprenal.00252.2006
   Hayden Melvin R, 2006, J Cardiometab Syndr, V1, P16, DOI 10.1111/j.0197-3118.2006.05454.x
   Hayden Melvin R, 2004, Nutr Metab (Lond), V1, P10, DOI 10.1186/1743-7075-1-10
   Hayden MR, 2004, NUTR J, V3, DOI 10.1186/1475-2891-3-4
   Hayden MR, 2003, CARDIOVASC DIABETOL, V2, DOI 10.1186/1475-2840-2-2
   Hayden Melvin R, 2003, Med Sci Monit, V9, pSR35
   Hayden Melvin R, 2002, JOP, V3, P86
   Hayden MR, 2002, CARDIOVASC DIABETOL, V1, DOI 10.1186/1475-2840-1-3
   Hayden Melvin R, 2008, J Cardiometab Syndr, V3, P55, DOI 10.1111/j.1559-4572.2008.08261.x
   Hayden Melvin R, 2008, J Cardiometab Syndr, V3, P234, DOI 10.1111/j.1559-4572.2008.00024.x
   Hayden MR, 2008, J AM SOC HYPERTENS, V2, P239, DOI 10.1016/j.jash.2007.12.002
   Hayden MR, 2004, MED SCI MONITOR, V10, pRA291
   Hayden MR, 2005, AM J NEPHROL, V25, P553, DOI 10.1159/000088810
   HAYDEN MR, 2006, CURR OPIN ENDOCRINOL, V13, P135
   Hayden MR, 2005, PRACTICAL DIABETOL, V24, P6
   Hayden MR., 2006, Insulin, V1, P22, DOI [10.1016/S1557-0843(06)80005-9, DOI 10.1016/S1557-0843(06)80005-9]
   Henegar C, 2008, GENOME BIOL, V9, DOI 10.1186/gb-2008-9-1-r14
   HIGASHIMORI K, 1991, HYPERTENSION, V17, P270, DOI 10.1161/01.HYP.17.3.270
   Holdsworth SR, 2008, J AM SOC NEPHROL, V19, P2254, DOI 10.1681/ASN.2008010015
   IMAI T, 1983, P NATL ACAD SCI-BIOL, V80, P7405, DOI 10.1073/pnas.80.24.7405
   Järvinen TAHJ, 2005, AM J SPORT MED, V33, P745, DOI 10.1177/0363546505274714
   Jin M, 1988, Am J Med, V84, P28, DOI 10.1016/0002-9343(88)90202-1
   JOHNSTON CI, 1992, J HYPERTENS, V10, pS13
   KLYDE BJ, 1979, J LIPID RES, V20, P691
   KLYDE BJ, 1979, J LIPID RES, V20, P705
   Kumar R, 2007, TRENDS ENDOCRIN MET, V18, P208, DOI 10.1016/j.tem.2007.05.001
   LANZILLO JJ, 1985, J BIOL CHEM, V260, P4938
   Lastra G, 2008, AM J PHYSIOL-ENDOC M, V295, pE110, DOI 10.1152/ajpendo.00258.2007
   Lau T, 2004, DIABETOLOGIA, V47, P240, DOI 10.1007/s00125-003-1295-1
   Leung Po Sing, 2006, J Cardiometab Syndr, V1, P197, DOI 10.1111/j.1559-4564.2006.05460.x
   Leung PS, 2007, J PHYSIOL-LONDON, V580, P31, DOI 10.1113/jphysiol.2006.126193
   Leung PS, 2003, INT J BIOCHEM CELL B, V35, P838, DOI 10.1016/S1357-2725(02)00179-6
   LILLIOJA S, 1987, J CLIN INVEST, V80, P415, DOI 10.1172/JCI113088
   LINDPAINTNER K, 1991, CARDIOLOGY, V79, P32, DOI 10.1159/000174905
   Liu J, 2009, NAT MED, V15, P940, DOI 10.1038/nm.1994
   Lubel JS, 2008, J GASTROEN HEPATOL, V23, P1327, DOI 10.1111/j.1440-1746.2008.05461.x
   LUDWIG J, 1980, MAYO CLIN PROC, V55, P434
   Ludwig J, 1997, J GASTROEN HEPATOL, V12, P398, DOI 10.1111/j.1440-1746.1997.tb00450.x
   Matoba S, 1999, CIRCULATION, V99, P817, DOI 10.1161/01.CIR.99.6.817
   Matveyenko AV, 2006, ILAR J, V47, P225, DOI 10.1093/ilar.47.3.225
   Matveyenko AV, 2006, DIABETES, V55, P2106, DOI 10.2337/db05-1672
   McKinley MJ, 2003, INT J BIOCHEM CELL B, V35, P901, DOI 10.1016/S1357-2725(02)00306-0
   Metcalfe DD, 1997, PHYSIOL REV, V77, P1033, DOI 10.1152/physrev.1997.77.4.1033
   Miyata K, 2008, CLIN EXP PHARMACOL P, V35, P922, DOI 10.1111/j.1440-1681.2008.04938.x
   Montgomery H, 2003, INT J BIOCHEM CELL B, V35, P758, DOI 10.1016/S1357-2725(03)00003-7
   Mulder P, 1997, CIRCULATION, V96, P1976, DOI 10.1161/01.CIR.96.6.1976
   Nangaku M, 2008, HYPERTENS RES, V31, P175, DOI 10.1291/hypres.31.175
   Nistala Ravi, 2006, J Cardiometab Syndr, V1, P47, DOI 10.1111/j.0197-3118.2006.05455.x
   Ohta Y, 2003, J CLIN BIOCHEM NUTR, V33, P83
   PAUL M, 1992, TRENDS CARDIOVAS MED, V2, P94, DOI 10.1016/1050-1738(92)90013-I
   Paul M, 2006, PHYSIOL REV, V86, P747, DOI 10.1152/physrev.00036.2005
   Peters H, 2007, NEPHROL DIAL TRANSPL, V22, P40, DOI 10.1093/ndt/gfl544
   Pitt B, 1999, NEW ENGL J MED, V341, P709, DOI 10.1056/NEJM199909023411001
   Pitt B, 2001, CARDIOVASC DRUG THER, V15, P79, DOI 10.1023/A:1011119003788
   Prasad A, 2004, CIRCULATION, V110, P1507, DOI 10.1161/01.CIR.0000141736.76561.78
   Robbins ME, 2006, INT J RADIAT ONCOL, V64, P6, DOI 10.1016/j.ijrobp.2005.08.033
   Rossi GP, 1999, CARDIOVASC RES, V43, P300, DOI 10.1016/S0008-6363(99)00110-8
   Sakurai K, 2001, BIOL PHARM BULL, V24, P876, DOI 10.1248/bpb.24.876
   Savaskan Egemen, 2005, Current Alzheimer Research, V2, P29, DOI 10.2174/1567205052772740
   Seccia TM, 2003, J AM COLL CARDIOL, V41, P666, DOI 10.1016/S0735-1097(02)02860-7
   Sharma A. K., 2006, V1, P1
   Sharma AM, 2002, HYPERTENSION, V40, P609, DOI 10.1161/01.HYP.0000036448.44066.53
   Silver RB, 2004, P NATL ACAD SCI USA, V101, P13607, DOI 10.1073/pnas.0403208101
   Sowers KM, 2010, OXID MED CELL LONGEV, V3, P109, DOI 10.4161/oxim.3.2.11354
   Stas S, 2007, ENDOCRINOLOGY, V148, P3773, DOI 10.1210/en.2006-1691
   Strain WD, 2002, J RENIN-ANGIO-ALDO S, V3, P243, DOI 10.3317/jraas.2002.045
   Tavazzi B, 2007, NEUROSURGERY, V61, P390, DOI 10.1227/01.NEU.0000255525.34956.3F
   Tikellis C, 2004, DIABETES, V53, P989, DOI 10.2337/diabetes.53.4.989
   Toblli JE, 2008, OBESITY, V16, P770, DOI 10.1038/oby.2007.114
   Tolman Keith G, 2007, Ther Clin Risk Manag, V3, P1153
   Tsuchiya M, 2008, ANESTH ANALG, V107, P1946, DOI 10.1213/ane.0b013e318187c96b
   TURK J, 1993, BIOCHEM BIOPH RES CO, V197, P1458, DOI 10.1006/bbrc.1993.2641
   VONLUTTEROTTI N, 1994, CIRCULATION, V89, P458, DOI 10.1161/01.CIR.89.1.458
   Wei Y, 2008, J HEPATOL, V49, P417, DOI 10.1016/j.jhep.2008.03.018
   Whaley-Connell A, 2011, CARDIORENAL MED, V1, P23, DOI 10.1159/000322827
   Wookey PJ, 1998, MINER ELECTROL METAB, V24, P389, DOI 10.1159/000057400
   Zhao HL, 2009, TRANSL RES, V153, P24, DOI 10.1016/j.trsl.2008.10.009
   Zhao HL, 2003, DIABETES, V52, P2759, DOI 10.2337/diabetes.52.11.2759
   Zhao W, 2007, BRIT J RADIOL, V80, pS23, DOI 10.1259/bjr/18237646
NR 117
TC 34
Z9 35
U1 0
U2 4
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1664-3828
EI 1664-5502
J9 CARDIORENAL MED
JI CardioRenal Med.
PY 2011
VL 1
IS 3
BP 193
EP 210
DI 10.1159/000329926
PG 18
WC Cardiac & Cardiovascular Systems; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Urology & Nephrology
GA 051ZM
UT WOS:000312167500007
PM 22096455
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Soukop, J
   Kazdová, L
   Hüttl, M
   Malínská, H
   Marková, I
   Oliyarnyk, O
   Miklánková, D
   Gurská, S
   Rácová, Z
   Poruba, M
   Vecera, R
AF Soukop, Jan
   Kazdova, Ludmila
   Huttl, Martina
   Malinska, Hana
   Markova, Irena
   Oliyarnyk, Olena
   Miklankova, Denisa
   Gurska, Sona
   Racova, Zuzana
   Poruba, Martin
   Vecera, Rostislav
TI Beneficial Effect of Fenofibrate in Combination with Silymarin on
   Parameters of Hereditary Hypertriglyceridemia-Induced Disorders in an
   Animal Model of Metabolic Syndrome
SO BIOMEDICINES
LA English
DT Article
DE fenofibrate; silymarin; triglycerides; metabolic syndrome; oxidative
   stress; insulin resistance; glycogen synthesis; reesterification of
   fatty acids
ID SPONTANEOUSLY HYPERTENSIVE-RATS; INSULIN-RESISTANCE; NONALCOHOLIC
   STEATOHEPATITIS; GLUCOSE-METABOLISM; OXIDATIVE STRESS; PPAR-ALPHA;
   PARAOXONASE; SENSITIVITY; THERAPY; REDUCE
AB Background: Hypertriglyceridemia has serious health risks such as cardiovascular disease, type 2 diabetes mellitus, nephropathy, and others. Fenofibrate is an effective hypolipidemic drug, but its benefits for ameliorating disorders associated with hypertriglyceridemia failed to be proven in clinical trials. Methods: To search for possible causes of this situation and possibilities of their favorable influence, we tested the effect of FF monotherapy and the combination of fenofibrate with silymarin on metabolic disorders in a unique model of hereditary hypertriglyceridemic rats (HHTg). Results: Fenofibrate treatment (100 mg/kg BW/day for four weeks) significantly decreased serum levels of triglyceride, (-77%) and free fatty acids (-29%), the hepatic accumulation of triglycerides, and the expression of genes encoding transcription factors involved in lipid metabolism (Srebf2, Nr1h4. Rxr alpha, and Slco1a1). In contrast, the hypertriglyceridemia-induced ectopic storage of lipids in muscles, the heart, and kidneys reduced glucose utilization in muscles and was not affected. In addition, fenofibrate reduced the activity of the antioxidant system, including Nrf2 expression (-35%) and increased lipoperoxidation in the liver and, to a lesser extent, in the kidneys and heart. Adding silymarin (micronized form, 600 mg/kg BW/day) to fenofibrate therapy increased the synthesis of glycogen in muscles, (+36%) and reduced hyperinsulinemia (-34%). In the liver, it increased the activity of the antioxidant system, including PON-1 activity and Nrf2 expression, and reduced the formation of lipoperoxides. The beneficial effect of combination therapy on the parameters of oxidative stress and lipoperoxidation was also observed, to a lesser extent, in the heart and kidneys. Conclusions: Our results suggest the potential beneficial use of the combination of FF with SLM in the treatment of hypertriglyceridemia-induced metabolic disorders.
C1 [Soukop, Jan; Racova, Zuzana; Poruba, Martin; Vecera, Rostislav] Palacky Univ Olomouc, Fac Med & Dent, Dept Pharmacol, Olomouc 77515, Czech Republic.
   [Kazdova, Ludmila; Huttl, Martina; Malinska, Hana; Markova, Irena; Oliyarnyk, Olena; Miklankova, Denisa] Inst Clin & Expt Med, Ctr Expt Med, Prague 14021, Czech Republic.
   [Gurska, Sona] Palacky Univ Olomouc, Inst Mol & Translat Med, Fac Med & Dent, Olomouc 77515, Czech Republic.
C3 Palacky University Olomouc; Institute for Clinical & Experimental
   Medicine (IKEM); Palacky University Olomouc
RP Poruba, M; Vecera, R (corresponding author), Palacky Univ Olomouc, Fac Med & Dent, Dept Pharmacol, Olomouc 77515, Czech Republic.
EM jan.soukop01@upol.cz; martin.poruba@upol.cz; rostislav.vecera@upol.cz
RI Oliyarnyk, Olena/Q-6380-2019
OI Poruba, Martin/0000-0003-1252-4971; SOUKOP, Jan/0000-0002-0930-4372;
   Malinska, Hana/0000-0002-9076-3399; Markova, Irena/0000-0002-4331-7636;
   Kazdova, Ludmila/0000-0003-0563-0186
FU Internal Grant Agency of Palacky University Olomouc; Czech Science
   Foundation;  [IGA_LF_2024_006];  [IN 00023001]
FX This study was supported by grant IGA_LF_2024_006 of the Internal Grant
   Agency of Palacky University Olomouc, a grant from the Czech Science
   Foundation and by the Ministry of Health of the Czech Republic under its
   program for the conceptual development of research organizations
   (Institute for Clinical and Experimental Medicine-IKEM, IN 00023001).
CR Abbasi F, 2008, AM J CARDIOL, V102, P64, DOI 10.1016/j.amjcard.2008.02.097
   Abd El-Haleim EA, 2016, WORLD J GASTROENTERO, V22, P2931, DOI 10.3748/wjg.v22.i10.2931
   Aggarwal R, 2022, JAMA-J AM MED ASSOC, V328, P737, DOI 10.1001/jama.2022.12567
   Ahmad J, 2017, DIGEST DIS SCI, V62, P3596, DOI 10.1007/s10620-017-4812-7
   Anderlová K, 2007, PHYSIOL RES, V56, P579, DOI 10.33549/physiolres.931058
   Belfort R, 2010, J CLIN ENDOCR METAB, V95, P829, DOI 10.1210/jc.2009-1487
   Bellavite P, 2023, MOLECULES, V28, DOI 10.3390/molecules28114491
   Borén J, 2013, J INTERN MED, V274, P25, DOI 10.1111/joim.12071
   Canfora I, 2024, INT J MOL SCI, V25, DOI 10.3390/ijms25179727
   Das Pradhan A, 2022, NEW ENGL J MED, V387, P1923, DOI 10.1056/NEJMoa2210645
   Dron JS, 2019, J CLIN LIPIDOL, V13, P80, DOI 10.1016/j.jacl.2018.10.006
   Duran EK, 2021, CLIN CHEM, V67, P183, DOI 10.1093/clinchem/hvaa296
   Fan WJ, 2019, J CLIN LIPIDOL, V13, P100, DOI 10.1016/j.jacl.2018.11.008
   Ferenci P, 2013, J HEPATOL, V58, P409, DOI 10.1016/j.jhep.2012.11.030
   Gillessen A, 2020, ADV THER, V37, P1279, DOI 10.1007/s12325-020-01251-y
   Ginsberg HN, 2010, NEW ENGL J MED, V362, P1563, DOI 10.1056/NEJMoa1001282
   GRONE EF, 1994, ATHEROSCLEROSIS, V107, P1, DOI 10.1016/0021-9150(94)90136-8
   Hegele RA, 2014, LANCET DIABETES ENDO, V2, P655, DOI 10.1016/S2213-8587(13)70191-8
   Kazdova L, 1997, ANN NY ACAD SCI, V827, P521, DOI 10.1111/j.1749-6632.1997.tb51863.x
   Keech A, 2005, LANCET, V366, P1849, DOI 10.1016/S0140-6736(05)67667-2
   Kostapanos MS, 2013, EUR J CLIN INVEST, V43, P522, DOI 10.1111/eci.12068
   Kowalska K, 2015, ANN CLIN LAB SCI, V45, P226
   Lee HJ, 2002, BIOCHEM BIOPH RES CO, V296, P293, DOI 10.1016/S0006-291X(02)00822-7
   MacDonald-Ramos K, 2021, ANN HEPATOL, V23, DOI 10.1016/j.aohep.2020.08.072
   Malinska H, 2015, NUTRITION, V31, P1045, DOI 10.1016/j.nut.2015.03.011
   Malínská H, 2010, MOL CELL BIOCHEM, V335, P119, DOI 10.1007/s11010-009-0248-5
   Markova I, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/8712979
   McCullough PA, 2011, REV CARDIOVASC MED, V12, P173, DOI 10.3909/ricm0619
   Mengs U, 2012, CURR PHARM BIOTECHNO, V13, P1964, DOI 10.2174/138920112802273353
   Miller M, 2024, CURR OPIN CARDIOL, V39, P286, DOI 10.1097/HCO.0000000000001136
   Montagner A, 2016, GUT, V65, P1202, DOI 10.1136/gutjnl-2015-310798
   Nakamura M, 2020, J PHYSIOL-LONDON, V598, P2977, DOI 10.1113/JP276747
   Olukman M, 2010, EXP DIABETES RES, DOI 10.1155/2010/828531
   Peng XY, 2022, CURR ATHEROSCLER REP, V24, P297, DOI 10.1007/s11883-022-01006-w
   Perreault L, 2011, METABOLISM, V60, P1107, DOI 10.1016/j.metabol.2010.12.003
   Pontremoli R, 2023, EUR J INTERN MED, V111, P90, DOI 10.1016/j.ejim.2023.02.019
   Poruba M, 2015, XENOBIOTICA, V45, P751, DOI 10.3109/00498254.2015.1010633
   Pravenec M, 2008, INT J OBESITY, V32, P1848, DOI 10.1038/ijo.2008.192
   Pravenec M, 2003, J BIOL CHEM, V278, P45209, DOI 10.1074/jbc.M304869200
   Qi NN, 2002, J BIOL CHEM, V277, P48501, DOI 10.1074/jbc.M206655200
   Ramnanan CJ, 2010, DIABETES, V59, P1302, DOI 10.2337/db09-1625
   Raposeiras-Roubin S, 2021, J AM COLL CARDIOL, V77, P3031, DOI 10.1016/j.jacc.2021.04.059
   Samuel VT, 2016, J CLIN INVEST, V126, P12, DOI 10.1172/JCI77812
   Saric M, 2012, CURR CARDIOL REP, V14, P342, DOI 10.1007/s11886-012-0261-2
   Sarma S, 2013, CIRC-CARDIOVASC IMAG, V6, P1048, DOI 10.1161/CIRCIMAGING.113.000565
   Shunmoogam N, 2018, VASC HEALTH RISK MAN, V14, P137, DOI 10.2147/VHRM.S165173
   Skop V, 2016, PHYSIOL RES, V65, P891, DOI 10.33549/physiolres.933304
   Skottová N, 2004, PHARMACOL RES, V50, P123, DOI 10.1016/j.phrs.2003.12.013
   Surai PF, 2015, ANTIOXIDANTS-BASEL, V4, P204, DOI 10.3390/antiox4010204
   Tajmohammadi A, 2018, PHYTOTHER RES, V32, P1933, DOI 10.1002/ptr.6153
   Tybjaerg-Hansen A, 2023, EUR HEART J, V44, P4196, DOI 10.1093/eurheartj/ehad419
   VRANA A, 1990, TRANSPLANT P, V22, P2579
   Wadhwa K, 2022, MOLECULES, V27, DOI 10.3390/molecules27165327
   Wlodarski A, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21186902
   Wu XJ, 2022, J DIABETES RES, V2022, DOI 10.1155/2022/9060405
   Yu XH, 2015, ADV CLIN CHEM, V71, P171, DOI 10.1016/bs.acc.2015.06.005
   Zicha J, 2006, PHYSIOL RES, V55, pS49, DOI 10.33549/physiolres.930000.55.S1.49
NR 57
TC 0
Z9 0
U1 6
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD JAN
PY 2025
VL 13
IS 1
AR 212
DI 10.3390/biomedicines13010212
PG 21
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA T4H6R
UT WOS:001404641000001
PM 39857794
OA gold
DA 2025-06-11
ER

PT J
AU Villegas-Romero, M
   Castrejón-Téllez, V
   Pérez-Torres, I
   Rubio-Ruiz, ME
   Carreón-Torres, E
   Díaz-Díaz, E
   del Valle-Mondragón, L
   Guarner-Lans, V
AF Villegas-Romero, Mariana
   Castrejon-Tellez, Vicente
   Perez-Torres, Israel
   Esther Rubio-Ruiz, Maria
   Carreon-Torres, Elizabeth
   Diaz-Diaz, Eulises
   del Valle-Mondragon, Leonardo
   Guarner-Lans, Veronica
TI Short-Term Exposure to High Sucrose Levels near Weaning Has a Similar
   Long-Lasting Effect on Hypertension as a Long-Term Exposure in Rats
SO NUTRIENTS
LA English
DT Article
DE critical window; hypertension; sucrose; endothelial nitric oxide
   synthase; oxidative stress; fatty acids
ID NITRIC-OXIDE SYNTHASE; LOW-DENSITY-LIPOPROTEIN; ADULT-BLOOD PRESSURE;
   OXIDATIVE STRESS; SUPEROXIDE-DISMUTASE; ENDOTHELIAL FUNCTION; VASCULAR
   REACTIVITY; PROTEIN-SYNTHESIS; HIGH-CARBOHYDRATE; ARACHIDONIC-ACID
AB Adverse conditions during early developmental stages permanently modify the metabolic function of organisms through epigenetic changes. Exposure to high sugar diets during gestation and/or lactation affects susceptibility to metabolic syndrome or hypertension in adulthood. The effect of a high sugar diet for shorter time lapses remains unclear. Here we studied the effect of short-term sucrose ingestion near weaning (postnatal days 12 and 28) (STS) and its effect after long-term ingestion, for a period of seven months (LTS) in rats. Rats receiving sucrose for seven months develop metabolic syndrome (MS). The mechanisms underlying hypertension in this model and those that underlie the effects of short-term exposure have not been studied. We explore NO and endothelin-1 concentration, endothelial nitric oxide synthase (eNOS) expression, fatty acid participation and the involvement of oxidative stress (OS) after LTS and STS. Blood pressure increased to similar levels in adult rats that received sucrose during short- and long-term glucose exposure. The endothelin-1 concentration increased only in LTS rats. eNOS and SOD2 expression determined by Western blot and total antioxidant capacity were diminished in both groups. Saturated fatty acids and arachidonic acid were only decreased in LTS rats. In conclusion, a high-sugar diet during STS increases the hypertension predisposition in adulthood to as high a level as LTS, and the mechanisms involved have similarities (participation of OS and eNOS and SOD expression) and differences (fatty acids and arachidonic acid only participate in LTS and an elevated level of endothelin-1 was only found in LTS) in both conditions. Changes in the diet during short exposure times in early developmental stages have long-lasting effects in determining hypertension susceptibility.
C1 [Villegas-Romero, Mariana; Castrejon-Tellez, Vicente; Esther Rubio-Ruiz, Maria; Guarner-Lans, Veronica] Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Perez-Torres, Israel] Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Carreon-Torres, Elizabeth] Inst Nacl Cardiol Ignacio Chavez, Dept Mol Biol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Diaz-Diaz, Eulises] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Vasco de Quiroga 15,Secc 16, Mexico City 14000, DF, Mexico.
   [del Valle-Mondragon, Leonardo] Inst Nacl Cardiol Ignacio Chavez, Dept Pharmacol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico; National Institute of Cardiology - Mexico;
   Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico; National Institute of Cardiology - Mexico
RP Guarner-Lans, V (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
EM mvromero21@gmail.com; vcastrejn@yahoo.com.mx; pertorisr@yahoo.com.mx;
   esther_rubio_ruiz@yahoo.com; qfbelizabethcm@yahoo.es;
   eulisesd@yahoo.com; leonardodvm65@hotmail.com; gualanv@yahoo.com
RI Guarner-Lans, Verónica/AFW-3723-2022; Pérez Torres, Israel/AAE-2579-2022
OI Carreon-Torres, Elizabeth/0000-0003-3600-249X; Guarner-Lans,
   Veronica/0000-0002-2655-7590; del Valle-Mondragon,
   Leonardo/0000-0002-2999-1050; Rubio-Ruiz, Maria
   Esther/0000-0002-8844-2078; Perez-Torres, Israel/0000-0001-6510-2954;
   Castrejon Tellez, Vicente/0000-0002-8518-6961
CR Aalinkeel R, 1999, AM J PHYSIOL-ENDOC M, V277, pE1061, DOI 10.1152/ajpendo.1999.277.6.E1061
   Aguayo-Mazzucato C, 2006, PLOS ONE, V1, DOI 10.1371/journal.pone.0000035
   Akondi RN, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01408
   Alexander BT, 2003, HYPERTENSION, V41, P457, DOI 10.1161/01.HYP.0000053448.95913.3D
   Banos G, 1997, AM J HYPERTENS, V10, P379
   Belik J, 2003, J APPL PHYSIOL, V95, P1979, DOI 10.1152/japplphysiol.00420.2003
   Benzie IFF, 1996, ANAL BIOCHEM, V239, P70, DOI 10.1006/abio.1996.0292
   BERENSON GS, 1989, AM J MED SCI, V298, P141, DOI 10.1097/00000441-198909000-00001
   BOLLI R, 1989, CIRC RES, V65, P607, DOI 10.1161/01.RES.65.3.607
   BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
   Guerra RC, 2014, INT J ENDOCRINOL, V2014, DOI 10.1155/2014/175080
   Chandrasekera PC, 2014, ALTEX-ALTERN ANIM EX, V31, P157, DOI 10.14573/altex.1309231
   Charniot JC, 2007, FREE RADICAL RES, V41, P911, DOI 10.1080/10715760701429775
   Chen YH, 2011, EMBO REP, V12, P534, DOI 10.1038/embor.2011.65
   Contreras RJ, 2000, PHYSIOL BEHAV, V71, P173, DOI 10.1016/S0031-9384(00)00331-0
   Costantini D, 2009, FUNCT ECOL, V23, P506, DOI 10.1111/j.1365-2435.2009.01546.x
   Craige SM, 2016, SCI REP-UK, V6, DOI 10.1038/srep38210
   Cury-Boaventura MF, 2006, LIFE SCI, V78, P1448, DOI 10.1016/j.lfs.2005.07.038
   Das UN, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-130
   de Lima TM, 2006, FEBS LETT, V580, P3287, DOI 10.1016/j.febslet.2006.04.091
   De Nigris V, 2015, CARDIOVASC DIABETOL, V14, DOI 10.1186/s12933-015-0278-0
   Didion SP, 2002, CIRC RES, V91, P938, DOI 10.1161/01.RES.0000043280.65241.04
   DIMARZO V, 1995, PROSTAG LEUKOTR ESS, V53, P239, DOI 10.1016/0952-3278(95)90123-X
   Drew BG, 2004, P NATL ACAD SCI USA, V101, P6999, DOI 10.1073/pnas.0306266101
   El Hafidi M, 2000, CLIN EXP HYPERTENS, V22, P99
   El-Hafidi M, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/2101562
   Farghali H, 2013, PHYSIOL RES, V62, P1, DOI 10.33549/physiolres.932434
   Garaulet M, 2011, NUTRITION, V27, P170, DOI 10.1016/j.nut.2010.01.004
   GEURSEN A, 1987, J NUTR, V117, P769, DOI 10.1093/jn/117.4.769
   GIRARD J, 1990, BIOL NEONATE, V58, P3, DOI 10.1159/000243294
   Goran MI, 2017, NUTRIENTS, V9, DOI 10.3390/nu9020146
   Griendling KK, 2000, ARTERIOSCL THROM VAS, V20, P2175, DOI 10.1161/01.ATV.20.10.2175
   Griendling KK, 2000, CIRC RES, V86, P494, DOI 10.1161/01.RES.86.5.494
   GROBBEE DE, 1990, J CARDIOVASC PHARM, V16, pS71
   Han F, 2015, CELL PHYSIOL BIOCHEM, V36, P1480, DOI 10.1159/000430312
   Hardy R, 2004, INT J EPIDEMIOL, V33, P121, DOI 10.1093/ije/dyh027
   Hernández-Díaz A, 2016, ARCH CARDIOL MEX, V86, P233, DOI 10.1016/j.acmx.2015.09.010
   Hostmark AT, 2013, LIPIDS HEALTH DIS, V12, DOI 10.1186/1476-511X-12-106
   Ide T, 1999, CIRC RES, V85, P357, DOI 10.1161/01.RES.85.4.357
   Kane MO, 2010, PFLUG ARCH EUR J PHY, V459, P671, DOI 10.1007/s00424-009-0759-7
   Kumarathasan P, 2001, ANAL BIOCHEM, V299, P37, DOI 10.1006/abio.2001.5362
   LANGLEY SC, 1994, CLIN SCI, V86, P217, DOI 10.1042/cs0860217
   Lawlor DA, 2005, CURR OPIN NEPHROL HY, V14, P259, DOI 10.1097/01.mnh.0000165893.13620.2b
   Lemosquet S, 2009, J DAIRY SCI, V92, P3244, DOI 10.3168/jds.2008-1610
   Li L, 2007, J HYPERTENS, V25, P1215, DOI 10.1097/HJH.0b013e3280f3c01a
   Lubrano V, 2006, CLIN EXP MED, V6, P84, DOI 10.1007/s10238-006-0100-0
   Lucas A, 1998, J NUTR, V128, p401S, DOI 10.1093/jn/128.2.401S
   del Campo CMZM, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19051456
   Mármol F, 2007, J PHYSIOL BIOCHEM, V63, P239, DOI 10.1007/BF03165787
   Mattagajasingh I, 2007, P NATL ACAD SCI USA, V104, P14855, DOI 10.1073/pnas.0704329104
   Minhas KM, 2006, CIRC RES, V98, P271, DOI 10.1161/01.RES.0000200181.59551.71
   Mu Jian-jun, 2008, Zhonghua Xinxueguanbing Zazhi, V36, P229
   Murdoch CE, 2006, CARDIOVASC RES, V71, P208, DOI 10.1016/j.cardiores.2006.03.016
   Nava P, 1997, HYPERTENSION, V30, P825, DOI 10.1161/01.HYP.30.4.825
   Osmond C, 2000, ENVIRON HEALTH PERSP, V108, P545, DOI 10.1289/ehp.00108s3545
   Ozanne SE, 2002, TRENDS ENDOCRIN MET, V13, P368, DOI 10.1016/S1043-2760(02)00666-5
   Park JY, 2003, BIOCHEM BIOPH RES CO, V303, P891, DOI 10.1016/S0006-291X(03)00436-4
   Pérez Méndez Óscar, 2007, Arch. Cardiol. Méx., V77, P17
   Pérez-Torres I, 2014, CLIN EXP HYPERTENS, V36, P123, DOI 10.3109/10641963.2013.789046
   Pérez-Torres I, 2009, FREE RADICAL RES, V43, P761, DOI 10.1080/10715760903045296
   Plagemann A, 2002, DIABETES CARE, V25, P16, DOI 10.2337/diacare.25.1.16
   Porter JP, 2007, AM J PHYSIOL-REG I, V293, pR334, DOI 10.1152/ajpregu.00887.2006
   Priante G, 2005, CLIN SCI, V109, P177, DOI 10.1042/CS20040369
   Raitakari OT, 2005, INT J OBESITY, V29, pS101, DOI 10.1038/sj.ijo.0803085
   Rubbo H, 2000, J BIOL CHEM, V275, P10812, DOI 10.1074/jbc.275.15.10812
   Rubbo H, 1995, ARCH BIOCHEM BIOPHYS, V324, P15, DOI 10.1006/abbi.1995.9935
   Rubbo H, 1996, METHOD ENZYMOL, V269, P385
   Rubio-Ruíz ME, 2014, PEPTIDES, V57, P101, DOI 10.1016/j.peptides.2014.04.021
   Rubio-Ruiz ME, 2010, HEART VESSELS, V25, P248, DOI 10.1007/s00380-009-1166-x
   Ruiz-Ramírez A, 2011, AM J PHYSIOL-ENDOC M, V301, pE1198, DOI 10.1152/ajpendo.00631.2010
   Rulquin H, 2004, J DAIRY SCI, V87, P340, DOI 10.3168/jds.S0022-0302(04)73173-2
   Rupp H, 1996, MOL CELL BIOCHEM, V162, P59
   Saavedra WF, 2002, CIRC RES, V90, P297, DOI 10.1161/hh0302.104531
   SAMPSON DA, 1986, J NUTR, V116, P365, DOI 10.1093/jn/116.3.365
   Samuelsson AM, 2013, FRONT PHYSIOL, V4, DOI 10.3389/fphys.2013.00014
   Sawyer DB, 2002, J MOL CELL CARDIOL, V34, P379, DOI 10.1006/jmcc.2002.1526
   Schreuder MF, 2006, J HYPERTENS, V24, P1337, DOI 10.1097/01.hjh.0000234114.33025.fd
   Seki Y, 2012, ENDOCRINOLOGY, V153, P1031, DOI 10.1210/en.2011-1805
   Serpillon S, 2009, AM J PHYSIOL-HEART C, V297, pH153, DOI 10.1152/ajpheart.01142.2008
   Shaughnessy DT, 2014, ENVIRON HEALTH PERSP, V122, P1271, DOI 10.1289/ehp.1408418
   Song F, 2001, DIABETES, V50, P2053, DOI 10.2337/diabetes.50.9.2053
   Srinivasan M, 2006, AM J PHYSIOL-ENDOC M, V290, pE129, DOI 10.1152/ajpendo.00248.2005
   Takimoto E, 2005, J CLIN INVEST, V115, P1221, DOI 10.1172/JCI200521968
   Tenorio F. A., 2005, REV MEXICANA CIENCIA, V36, P31
   Trostchansky A, 2001, ARCH BIOCHEM BIOPHYS, V395, P225, DOI 10.1006/abbi.2001.2583
   Turgeon Paul J, 2014, Med Epigenet, V2, P37
   Umar S, 2010, MOL CELL BIOCHEM, V333, P191, DOI 10.1007/s11010-009-0219-x
   Velázquez-Villegas LA, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0069338
   Vendrov AE, 2017, J AM HEART ASSOC, V6, DOI 10.1161/JAHA.117.006775
   Ventura EE, 2011, OBESITY, V19, P868, DOI 10.1038/oby.2010.255
   Verlengia R, 2003, LIPIDS, V38, P1157, DOI 10.1007/s11745-003-1174-x
   Vila L, 2004, MED RES REV, V24, P399, DOI 10.1002/med.10065
   Wallace DC, 2005, ANNU REV GENET, V39, P359, DOI 10.1146/annurev.genet.39.110304.095751
   Wallace DC, 2010, MITOCHONDRION, V10, P12, DOI 10.1016/j.mito.2009.09.006
   White CN, 2010, J BIOL CHEM, V285, P13712, DOI 10.1074/jbc.M109.090225
   Woods LL, 2004, KIDNEY INT, V65, P1339, DOI 10.1111/j.1523-1755.2004.00511.x
   Xavier R., 2007, ASEAN FOOD J, V14, P69
   Xia Y, 1998, J BIOL CHEM, V273, P25804, DOI 10.1074/jbc.273.40.25804
   Zheng J, 2016, NUTRIENTS, V8, DOI 10.3390/nu8110685
NR 99
TC 15
Z9 16
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2018
VL 10
IS 6
AR 728
DI 10.3390/nu10060728
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GK8VC
UT WOS:000436507200072
PM 29882756
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Zorach, B
   Shaw, PW
   Bourque, J
   Kuruvilla, S
   Balfour, PC
   Yang, Y
   Mathew, R
   Pan, J
   Gonzalez, JA
   Taylor, AM
   Meyer, CH
   Epstein, FH
   Kramer, CM
   Salerno, M
AF Zorach, Benjamin
   Shaw, Peter W.
   Bourque, Jamieson
   Kuruvilla, Sujith
   Balfour, Pelbreton C.
   Yang, Yang
   Mathew, Roshin
   Pan, Jonathan
   Gonzalez, Jorge A.
   Taylor, Angela M.
   Meyer, Craig H.
   Epstein, Frederick H.
   Kramer, Christopher M.
   Salerno, Michael
TI Quantitative cardiovascular magnetic resonance perfusion imaging
   identifies reduced flow reserve in microvascular coronary artery disease
SO JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
LA English
DT Article
DE Cardiovascular magnetic resonance; Microvascular disease; Myocardial
   perfusion reserve; Non-obstructive coronary artery disease; Angina;
   Women; Diabetes; Metabolic syndrome
ID MYOCARDIAL-PERFUSION; HEART-DISEASE; CHEST-PAIN; DYSFUNCTION; WOMEN;
   ANGIOGRAPHY; ASSOCIATION; ISCHEMIA; UPDATE; RISK
AB Background: Preliminary semi-quantitative cardiovascular magnetic resonance (CMR) perfusion studies have demonstrated reduced myocardial perfusion reserve (MPR) in patients with angina and risk factors for microvascular disease (MVD), however fully quantitative CMR has not been studied. The purpose of this study is to evaluate whether fully quantitative CMR identifies reduced MPR in this population, and to investigate the relationship between epicardial atherosclerosis, left ventricular hypertrophy (LVH), extracellular volume (ECV), and perfusion.
   Methods: Forty-six patients with typical angina and risk factors for MVD (females, or males with diabetes or metabolic syndrome) who had no obstructive coronary artery disease by coronary angiography and 20 healthy control subjects underwent regadenoson stress CMR perfusion imaging using a dual-sequence quantitative spiral pulse sequence to quantify MPR. Subjects also underwent T1 mapping to quantify ECV, and computed tomographic (CT) coronary calcium scoring to assess atherosclerosis burden.
   Results: In patients with risk factors for MVD, both MPR (2.21 [1.95,2.69] vs. 2.93 [2.763.19], p < 0.001) and stress myocardial perfusion (2.65 +/- 0.62 ml/min/g, vs. 3.17 +/- 0.49 ml/min/g p < 0.002) were reduced as compared to controls. These differences remained after adjusting for age, left ventricular (LV) mass, body mass index (BMI), and gender. There were no differences in native T1 or ECV between subjects and controls.
   Conclusions: Stress myocardial perfusion and MPR as measured by fully quantitative CMR perfusion imaging are reduced in subjects with risk factors for MVD with no obstructive CAD as compared to healthy controls. Neither myocardial hypertrophy nor fibrosis accounts for these differences.
C1 [Zorach, Benjamin; Bourque, Jamieson; Balfour, Pelbreton C.; Yang, Yang; Mathew, Roshin; Pan, Jonathan; Taylor, Angela M.; Kramer, Christopher M.; Salerno, Michael] Univ Virginia Hlth Syst, Cardiol Div, Dept Med, Charlottesville, VA 22903 USA.
   [Shaw, Peter W.] Berkshire Med Ctr, Pittsfield, MA USA.
   [Bourque, Jamieson; Meyer, Craig H.; Epstein, Frederick H.; Kramer, Christopher M.; Salerno, Michael] Univ Virginia Hlth Syst, Cardiovasc Imaging Ctr, Dept Radiol, Charlottesville, VA 22903 USA.
   [Kuruvilla, Sujith] Univ Penn, Dept Med, Philadelphia VA Med Ctr, Perelman Sch Med, Philadelphia, PA 19104 USA.
   [Yang, Yang; Meyer, Craig H.; Epstein, Frederick H.; Salerno, Michael] Univ Virginia Hlth Syst, Dept Biomed Engn, Charlottesville, VA 22903 USA.
   [Gonzalez, Jorge A.] Scripps Clin, Div Cardiovasc Dis, Div Cardiol, Cardiovasc Imaging,Div Radiol, San Diego, CA USA.
C3 University of Virginia; University of Virginia (UVA) Health System;
   University of Virginia; University of Virginia (UVA) Health System;
   University of Pennsylvania; Pennsylvania Medicine; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); Philadelphia
   Veterans Affairs Medical Center; University of Virginia; University of
   Virginia (UVA) Health System; Scripps Research Institute
RP Kramer, CM; Salerno, M (corresponding author), Univ Virginia Hlth Syst, Cardiol Div, Dept Med, Charlottesville, VA 22903 USA.; Kramer, CM; Salerno, M (corresponding author), Univ Virginia Hlth Syst, Cardiovasc Imaging Ctr, Dept Radiol, Charlottesville, VA 22903 USA.; Salerno, M (corresponding author), Univ Virginia Hlth Syst, Dept Biomed Engn, Charlottesville, VA 22903 USA.
EM ckramer@virginia.edu; ms5pc@virginia.edu
RI Carrizosa, Jorge/MVX-8993-2025; Yang, Yang/H-7280-2019
OI Taylor, Angela/0000-0003-4927-4320; Yang, Yang/0000-0002-2841-4243
FU UVA Health System Clinical Research Grant [NIH K23 HL112910, NIH K23
   HL119620, R01 HL131919, 5T32EB003841, R01 EB001763]; Siemens Medical
   Solutions
FX The work was funded by UVA Health System Clinical Research Grant, NIH
   K23 HL112910, NIH K23 HL119620, R01 HL131919, 5T32EB003841, R01
   EB001763, and Siemens Medical Solutions.
CR Avants BB, 2011, NEUROIMAGE, V54, P2033, DOI 10.1016/j.neuroimage.2010.09.025
   AXEL L, 1983, INVEST RADIOL, V18, P94, DOI 10.1097/00004424-198301000-00018
   Bhave NM, 2012, J CARDIOVASC MAGN R, V14, DOI 10.1186/1532-429X-14-89
   Costa MA, 2007, J AM COLL CARDIOL, V50, P514, DOI 10.1016/j.jacc.2007.04.053
   Crea F, 2014, EUR HEART J, V35, P1101, DOI 10.1093/eurheartj/eht513
   Di Carli MF, 2011, J NUCL MED, V52, P1369, DOI 10.2967/jnumed.110.082883
   Graf S, 2007, J NUCL MED, V48, P175
   Jerosch-Herold M, 2010, J CARDIOVASC MAGN R, V12, DOI 10.1186/1532-429X-12-57
   Lanza GA, 2010, CIRCULATION, V121, P2317, DOI 10.1161/CIRCULATIONAHA.109.900191
   Lustig M, 2010, MAGN RESON MED, V64, P457, DOI 10.1002/mrm.22428
   Manabe O, 2009, J NUCL MED, V50, P68, DOI 10.2967/jnumed.108.055673
   Marzilli M, 2012, J AM COLL CARDIOL, V60, P951, DOI 10.1016/j.jacc.2012.02.082
   Merz CNB, 2017, CIRCULATION, V135, P1075, DOI 10.1161/CIRCULATIONAHA.116.024534
   Mordini FE, 2014, JACC-CARDIOVASC IMAG, V7, P14, DOI 10.1016/j.jcmg.2013.08.014
   Morton G, 2012, J AM COLL CARDIOL, V60, P1546, DOI 10.1016/j.jacc.2012.05.052
   Mozaffarian D, 2016, CIRCULATION, V133, P447, DOI 10.1161/CIR.0000000000000366
   Murthy VL, 2012, CIRCULATION, V126, P1858, DOI 10.1161/CIRCULATIONAHA.112.120402
   Mygind ND, 2016, J CARDIOVASC MAGN R, V18, DOI 10.1186/s12968-016-0295-5
   Naresh NK, 2016, J CARDIOVASC MAGN R, V18, DOI 10.1186/s12968-016-0273-y
   Patel AR, 2010, J AM COLL CARDIOL, V56, P561, DOI 10.1016/j.jacc.2010.02.061
   Patel MR, 2010, NEW ENGL J MED, V362, P886, DOI 10.1056/NEJMoa0907272
   Pepine CJ, 2010, J AM COLL CARDIOL, V55, P2825, DOI 10.1016/j.jacc.2010.01.054
   Reis SE, 2001, AM HEART J, V141, P735, DOI 10.1067/mhj.2001.114198
   Salerno M, 2014, CIRC-CARDIOVASC IMAG, V7, P639, DOI 10.1161/CIRCIMAGING.113.001584
   Schulz-Menger J, 2013, J CARDIOVASC MAGN R, V15, DOI 10.1186/1532-429X-15-35
   Shufelt CL, 2013, CARDIOVASC DIAGN THE, V3, P153, DOI 10.3978/j.issn.2223-3652.2013.08.02
   Taqueti VR, 2017, CIRCULATION, V135, P566, DOI 10.1161/CIRCULATIONAHA.116.023266
   Thomson LEJ, 2015, CIRC-CARDIOVASC IMAG, V8, DOI 10.1161/CIRCIMAGING.114.002481
   Vasu S, 2011, J CARDIOVASC MAGN S1, V13, pP128
   Wöhrle J, 2006, J CARDIOVASC MAGN R, V8, P781, DOI 10.1080/10976640600737649
   Yang Y, 2014, J CARDIOVASC MAGN S1, V16, pP227
   Yang Y, 2013, J CARDIOVASC MAGN S1, V15, pE12
NR 32
TC 79
Z9 81
U1 0
U2 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1097-6647
EI 1532-429X
J9 J CARDIOVASC MAGN R
JI J. Cardiov. Magn. Reson.
PD FEB 22
PY 2018
VL 20
AR 14
DI 10.1186/s12968-018-0435-1
PG 8
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
   Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
   Medical Imaging
GA FX0WQ
UT WOS:000425768500001
PM 29471856
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, L
   Xu, D
   Zhang, BJ
   Liu, YS
   Chu, FL
   Guo, YM
   Gong, J
   Zheng, X
   Chen, LB
   Wang, H
AF Zhang, Li
   Xu, Dan
   Zhang, Benjian
   Liu, Yansong
   Chu, Fenglong
   Guo, Yuming
   Gong, Jun
   Zheng, Xun
   Chen, Liaobin
   Wang, Hui
TI Prenatal Food Restriction Induces a
   Hypothalamic-Pituitary-Adrenocortical Axis-associated Neuroendocrine
   Metabolic Programmed Alteration in Adult Offspring Rats
SO ARCHIVES OF MEDICAL RESEARCH
LA English
DT Article
DE Food restriction; Intrauterine growth restriction;
   Hypothalamic-pituitary-adrenal axis; Unpredictable chronic stress;
   High-fat diet; Metabolic syndrome
ID HIGH-FAT-DIET; CATCH-UP GROWTH; GREAT CHINESE FAMINE; ADRENAL AXIS;
   LATE-GESTATION; MATERNAL UNDERNUTRITION; NUTRIENT RESTRICTION;
   SEX-DIFFERENCES; FETAL ORIGINS; STRESS
AB Background and Aims. Intrauterine growth restriction produces susceptibility to adult metabolic syndrome, which may be caused by the permanent alteration of the hypothalamic-pituitary-adrenocortical (HPA) axis. We aimed to verify that HPA axis-associated neuroendocrine metabolic programming is altered in food-restricted (FR) offspring.
   Methods. Maternal rats were fed a restricted diet from gestational day 11 until full-term delivery, all pups were fed a high-fat diet after weaning and exposed to unpredictable chronic stress (UCS) during postnatal weeks 17-20.
   Results. Serum levels of adrenocorticotrophic hormone and corticosterone in adult offspring of the prenatal FR group were lower than the control (CN) rats before UCS but increased significantly after UCS. Serum glucose levels in the FR group were normal before UCS but increased after UCS. Serum insulin levels were significantly decreased in FR males but showed a slight increase in FR females before UCS; however, insulin levels decreased significantly in the FR male and female rats after UCS. Before UCS, serum lipid levels were higher in the FR males but were normal in the FR females; after UCS, FR males had a slight decrease and FR females had an increasing trend in serum lipids levels. Lipid droplets in the hypothalamus, pituitary gland, and livers of the FR group indicated steatosis.
   Conclusions. These results suggest that prenatal food restriction alters HPA axis-associated neuroendocrine metabolism in adult offspring fed a high-fat diet, which may originate from the intrauterine programming and increase the susceptibility to adult metabolic diseases. (C) 2013 IMSS. Published by Elsevier Inc.
C1 [Zhang, Li; Xu, Dan; Zhang, Benjian; Liu, Yansong; Guo, Yuming; Gong, Jun; Zheng, Xun; Wang, Hui] Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Hubei Province, Peoples R China.
   [Xu, Dan; Wang, Hui] Wuhan Univ, Res Ctr Food & Drug Evaluat, Wuhan 430071, Hubei Province, Peoples R China.
   [Chu, Fenglong; Chen, Liaobin] Wuhan Univ, Dept Orthoped Surg, Zhongnan Hosp, Wuhan 430071, Hubei Province, Peoples R China.
C3 Wuhan University; Wuhan University; Wuhan University
RP Wang, H (corresponding author), Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Hubei Province, Peoples R China.
EM wanghui19@whu.edu.cn
RI Guo, Yuming/AAH-1124-2021; Zhang, Benjian/ABC-1130-2020
OI Gong, Jun/0000-0001-9744-7201
FU National Natural Science Foundation of China [30830112, 81072709,
   81220108026, 81202240]; Chinese Ministry of Education [V200801]
FX This work was supported by grants from the National Natural Science
   Foundation of China (No. 30830112, 81072709, 81220108026 and 81202240),
   and the Key Grant Project of the Chinese Ministry of Education (No.
   V200801).
CR Aguila MB, 2003, NUTRITION, V19, P347, DOI 10.1016/S0899-9007(02)00934-6
   Alisi A, 2011, INT J ENDOCRINOL, V2011, DOI 10.1155/2011/269853
   Amengual-Cladera E, 2012, METABOLISM, V61, P1108, DOI 10.1016/j.metabol.2011.12.016
   Anagnostis P, 2009, J CLIN ENDOCR METAB, V94, P2692, DOI 10.1210/jc.2009-0370
   [Anonymous], AM J OBSTET GYNECOL
   Athyros VG, 2005, CURR MED RES OPIN, V21, P1157, DOI 10.1185/030079905X53333
   Barker DJP, 2001, BRIT MED BULL, V60, P69, DOI 10.1093/bmb/60.1.69
   Boersma B, 1997, ENDOCR REV, V18, P646, DOI 10.1210/er.18.5.646
   Brown RW, 1996, BIOCHEM J, V313, P1007, DOI 10.1042/bj3131007
   Buettner R, 2006, J MOL ENDOCRINOL, V36, P485, DOI 10.1677/jme.1.01909
   Burns SP, 1997, J CLIN INVEST, V100, P1768, DOI 10.1172/JCI119703
   Choi DC, 2008, PSYCHONEUROENDOCRINO, V33, P659, DOI 10.1016/j.psyneuen.2008.02.006
   Coulter CL, 2002, BIOL REPROD, V67, P584, DOI 10.1095/biolreprod67.2.584
   Coupé B, 2009, AM J PHYSIOL-REG I, V297, pR813, DOI 10.1152/ajpregu.00201.2009
   Delaunay F, 1997, J CLIN INVEST, V100, P2094, DOI 10.1172/JCI119743
   Desai M, 2005, AM J PHYSIOL-REG I, V288, pR91, DOI 10.1152/ajpregu.00340.2004
   Desai M, 1997, AM J PHYSIOL-GASTR L, V272, pG1083, DOI 10.1152/ajpgi.1997.272.5.G1083
   Desai M, 2007, AM J OBSTET GYNECOL, V196, P555, DOI 10.1016/j.ajog.2006.11.036
   Desai M, 2007, AM J PHYSIOL-REG I, V293, pR2306, DOI 10.1152/ajpregu.00783.2006
   Fowden AL, 2004, REPRODUCTION, V127, P515, DOI 10.1530/rep.1.00033
   Fraulob JC, 2010, J CLIN BIOCHEM NUTR, V46, P212, DOI 10.3164/jcbn.09-83
   Da Silveira VMF, 2008, REV SAUDE PUBL, V42, P10, DOI 10.1590/S0034-89102008000100002
   Garg M, 2006, AM J PHYSIOL-ENDOC M, V290, pE1218, DOI 10.1152/ajpendo.00474.2005
   Green AS, 2010, J ENDOCRINOL, V205, P211, DOI 10.1677/JOE-09-0399
   Holness MJ, 2000, BIOCHEM J, V349, P657, DOI 10.1042/bj3490657
   Kanaka-Gantenbein C, 2010, ANN NY ACAD SCI, V1205, P99, DOI 10.1111/j.1749-6632.2010.05683.x
   Karadag A, 2009, PEDIATR PULM, V44, P635, DOI 10.1002/ppul.21030
   Kobayasi R, 2010, J HYPERTENS, V28, P2111, DOI 10.1097/HJH.0b013e32833ca68c
   Kolovou GD, 2007, AM J MED SCI, V333, P362, DOI 10.1097/MAJ.0b013e318065c3a1
   Langdon KD, 2011, NEUROSCIENCE, V182, P82, DOI 10.1016/j.neuroscience.2011.03.028
   Lesage J, 2001, ENDOCRINOLOGY, V142, P1692, DOI 10.1210/en.142.5.1692
   Liang G, 2011, EXP TOXICOL PATHOL, V63, P607, DOI 10.1016/j.etp.2010.04.015
   Lingas RI, 2001, NEUROENDOCRINOLOGY, V73, P302, DOI 10.1159/000054647
   Liu L, 2012, TOXICOL LETT, V214, P307, DOI 10.1016/j.toxlet.2012.09.001
   Liu YS, 2012, TOXICOL APPL PHARM, V262, P205, DOI 10.1016/j.taap.2012.05.002
   Lucas A, 1996, BRIT J NUTR, V76, P605, DOI 10.1079/BJN19960066
   Manuel-Apolinar L, 2010, ARCH MED RES, V41, P240, DOI 10.1016/j.arcmed.2010.06.002
   Matveyenko AV, 2010, ENDOCRINOLOGY, V151, P5647, DOI 10.1210/en.2010-0978
   McMillen IC, 2005, PHYSIOL REV, V85, P571, DOI 10.1152/physrev.00053.2003
   Morrow AL, 2001, INT REV NEUROBIOL, V46, P349
   Ozanne SE, 2002, TRENDS ENDOCRIN MET, V13, P368, DOI 10.1016/S1043-2760(02)00666-5
   Panchal SK, 2011, J BIOMED BIOTECHNOL, DOI 10.1155/2011/351982
   Ravelli ACJ, 1999, AM J CLIN NUTR, V70, P811
   Reusens B, 2011, AM J CLIN NUTR, V94, p1824S, DOI 10.3945/ajcn.110.000729
   Roseboom T, 2006, EARLY HUM DEV, V82, P485, DOI 10.1016/j.earlhumdev.2006.07.001
   Sebaai N, 2002, NEUROENDOCRINOLOGY, V76, P243, DOI 10.1159/000065947
   Shin AC, 2010, INT J OBESITY, V34, P1218, DOI 10.1038/ijo.2010.34
   Somm E, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0050131
   Tannenbaum BM, 1997, AM J PHYSIOL-ENDOC M, V273, pE1168, DOI 10.1152/ajpendo.1997.273.6.E1168
   Tosh DN, 2010, AM J PHYSIOL-GASTR L, V299, pG1023, DOI 10.1152/ajpgi.00052.2010
   Touati S, 2011, MED SCI SPORT EXER, V43, P398, DOI 10.1249/MSS.0b013e3181eeb12d
   Underwood BA, 2002, NUTR REV, V60, pS7, DOI 10.1301/00296640260130425
   Valtat B, 2011, DIABETOLOGIA, V54, P350, DOI 10.1007/s00125-010-1898-2
   Vieau D, 2007, PSYCHONEUROENDOCRINO, V32, pS16, DOI 10.1016/j.psyneuen.2007.03.014
   Walker BR, 2006, DIABETIC MED, V23, P1281, DOI 10.1111/j.1464-5491.2006.01998.x
   Wang H, 2006, PHARMACOL RES, V53, P28, DOI 10.1016/j.phrs.2005.08.005
   Wang YH, 2010, OBESITY, V18, P588, DOI 10.1038/oby.2009.296
   Weinberg J, 2008, J NEUROENDOCRINOL, V20, P470, DOI 10.1111/j.1365-2826.2008.01669.x
   Willner P, 2005, NEUROPSYCHOBIOLOGY, V52, P90, DOI 10.1159/000087097
   Wolfe D, 2012, AM J OBSTET GYNECOL, V207, DOI 10.1016/j.ajog.2012.07.033
   Woods SC, 2003, J NUTR, V133, P1081, DOI 10.1093/jn/133.4.1081
   Xita N, 2010, ANN NY ACAD SCI, V1205, P148, DOI 10.1111/j.1749-6632.2010.05658.x
   Xn D, 2012, TOXICOL APPL PHARM, V264, P395, DOI 10.1016/j.taap.2012.08.016
   Xu D, 2012, TOXICOL LETT, V209, P282, DOI 10.1016/j.toxlet.2012.01.006
   Xu D, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0044497
   Xu D, 2011, ENVIRON TOXICOL PHAR, V32, P356, DOI 10.1016/j.etap.2011.08.003
   Yang Z, 2008, OBES REV, V9, P95, DOI 10.1111/j.1467-789X.2007.00447.x
   Yin YY, 2007, CHINESE MED J-PEKING, V120, P1088, DOI 10.1097/00029330-200706020-00011
   Yuan QX, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025167
   Zheng X, 2012, EUR J CLIN NUTR, V66, P231, DOI 10.1038/ejcn.2011.161
NR 70
TC 35
Z9 40
U1 1
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0188-4409
EI 1873-5487
J9 ARCH MED RES
JI Arch. Med. Res.
PD JUL
PY 2013
VL 44
IS 5
BP 335
EP 345
DI 10.1016/j.arcmed.2013.07.006
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 223YH
UT WOS:000324847900002
PM 23911676
DA 2025-06-11
ER

PT J
AU Hattan, N
   Chilian, WM
   Park, F
   Rocic, P
AF Hattan, Naoichiro
   Chilian, William M.
   Park, Frank
   Rocic, Petra
TI Restoration of coronary collateral growth in the Zucker obese rat:
   Impact of VEGF and ecSOD
SO BASIC RESEARCH IN CARDIOLOGY
LA English
DT Article
DE collateral growth; gene therapy; coronary circulation; VEGF; obesity
ID ENDOTHELIAL DYSFUNCTION; NITRIC-OXIDE; GENE-THERAPY; ANGIOGENESIS;
   ISCHEMIA; REPERFUSION; LIVER
AB The metabolic syndrome (MS), a condition characterized by several risk factors for coronary artery disease, including obesity, is associated with endothelial dysfunction and oxidative stress. Because proper endothelial function is essential for signaling of certain growth factors (vascular endothelial growth factor, VEGF) we hypothesized that coronary collateral growth (CCG) is impaired in a model of the MS. To test this hypothesis, we stimulated coronary collateral growth in pre-diabetic Zucker obese fatty rats (OZR) and lean littermates (LZR) by using episodic, repetitive ischemia (RI: 40 s left anterior descending arterial occlusion, 24/d for 14 d). Myocardial blood flow (MBF, radioactive microspheres) was measured in the normal (NZ) and collateral-dependent (ischemic) zones (CZ); CCG was assessed as a ratio of CZ/NZ flow (unity represents complete restoration of CZ flow). In LZR, CZ/NZ ratio increased from 0.18 +/- 0.03 to 0.81 +/- 0.07 after RI (P < 0.05). In contrast, in OZR rats CZ/NZ did not increase after RI (0.15 +/- 0.04 vs 0.18 +/- 0.04). To rectify abrogated collateral growth in OZR, we employed VEGF gene therapy (VEGF-transduced, strained-matched, cultured vascular smooth muscle cells [cVSMCs], delivered intracoronary). VEGF therapy modestly but not significantly increased the CZ/NZ ratio after RI (0.16 +/- 0.05 vs 0.33 +/- 0.06). To facilitate VEGF signaling,we reduced oxidative stress by transducing cVSMCs with both ecSOD and VEGF. This increased the CZ/NZ flow ratio after RI to 0.52 +/- 0.04 (p < 0.05 vs. OZR [(0.19 +/- 0.04]) indicating partial restoration of collateral growth. Our results demonstrate that coronary collateral growth is impaired in a model of the metabolic syndrome and that growth factor gene therapy with VEGF is made far more effective when it is coupled to an intervention that reduces oxidative stress.
C1 Louisiana State Univ, Hlth Sci Ctr, Dept Physiol, New Orleans, LA 70112 USA.
   Louisiana State Univ, Hlth Sci Ctr, Dept Pharmacol, Cardiovasc Ctr Excellence,Program Gene Therapy, New Orleans, LA 70112 USA.
C3 Louisiana State University System; Louisiana State University Health
   Sciences Center New Orleans; Louisiana State University System;
   Louisiana State University Health Sciences Center New Orleans
RP Rocic, P (corresponding author), Louisiana State Univ, Hlth Sci Ctr, Dept Physiol, 1901 Perdido St,Med Educ Bldg, New Orleans, LA 70112 USA.
EM procic@gmail.com
RI Park, Frank/I-4590-2019
OI Park, Frank/0000-0003-2324-2937; Rocic, Petra/0000-0002-5781-3075
FU NCRR NIH HHS [RR 018766] Funding Source: Medline; NHLBI NIH HHS [HL
   65203, HL 73755, HL 32788] Funding Source: Medline
CR Brzezinska AK, 2005, AM J PHYSIOL-HEART C, V289, pH2379, DOI 10.1152/ajpheart.00132.2005
   CHILIAN WM, 1990, AM J PHYSIOL, V258, pH1103, DOI 10.1152/ajpheart.1990.258.4.H1103
   Félétou M, 2006, AM J PHYSIOL-HEART C, V291, pH985, DOI 10.1152/ajpheart.00292.2006
   FOCARDI M, 2007, AM J PHYSL HEART CIR
   Hattan N, 2004, AM J PHYSIOL-HEART C, V287, pH488, DOI 10.1152/ajpheart.00145.2004
   Hughes GC, 2005, EXPERT REV CARDIOVAS, V3, P521, DOI 10.1586/14779072.3.3.521
   Jacobi J, 2005, FREE RADICAL BIO MED, V39, P1238, DOI 10.1016/j.freeradbiomed.2005.06.010
   Kobara M, 2003, BASIC RES CARDIOL, V98, P319, DOI 10.1007/s00395-003-0423-x
   Konukoglu D, 2006, ARCH MED RES, V37, P602, DOI 10.1016/j.arcmed.2005.12.002
   Laukkanen MO, 2001, J GENE MED, V3, P321, DOI 10.1002/jgm.194
   Lee SU, 2006, TOXICOL PATHOL, V34, P3, DOI 10.1080/01926230500499415
   Lei Y, 2004, BASIC RES CARDIOL, V99, P121, DOI 10.1007/s00395-004-0447-x
   LYNCH RE, 1978, J BIOL CHEM, V253, P4697
   Martorana PA, 1998, BASIC RES CARDIOL, V93, P257, DOI 10.1007/s003950050093
   Matsunaga T, 2000, CIRCULATION, V102, P3098
   Nathoe HM, 2006, AM J CARDIOL, V98, P31, DOI 10.1016/j.amjcard.2006.01.050
   Park F, 2000, BLOOD, V96, P1173, DOI 10.1182/blood.V96.3.1173.015k34_1173_1176
   Picchi A, 2006, CIRC RES, V99, P69, DOI 10.1161/01.RES.0000229685.37402.80
   Serkova NJ, 2006, J HEPATOL, V44, P956, DOI 10.1016/j.jhep.2005.07.009
   Simons M, 2000, CIRCULATION, V102, pE73, DOI 10.1161/01.CIR.102.11.e73
   Terada LS, 1996, AM J PHYSIOL-HEART C, V270, pH945, DOI 10.1152/ajpheart.1996.270.3.H945
   Toyota E, 2005, CIRCULATION, V112, P2108, DOI 10.1161/CIRCULATIONAHA.104.526954
   Zachary I, 2001, AM J PHYSIOL-CELL PH, V280, pC1375, DOI 10.1152/ajpcell.2001.280.6.C1375
NR 23
TC 40
Z9 45
U1 0
U2 2
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0300-8428
EI 1435-1803
J9 BASIC RES CARDIOL
JI Basic Res. Cardiol.
PD MAY
PY 2007
VL 102
IS 3
BP 217
EP 223
DI 10.1007/s00395-007-0646-3
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 154PK
UT WOS:000245519500004
PM 17323199
DA 2025-06-11
ER

PT J
AU Kupczyk, D
   Bilski, R
   Sokolowski, K
   Pawlowska, M
   Wozniak, A
   Szewczyk-Golec, K
AF Kupczyk, D.
   Bilski, R.
   Sokolowski, K.
   Pawlowska, M.
   Wozniak, A.
   Szewczyk-Golec, K.
TI Paraoxonase 1: The Lectin-Like Oxidized LDL Receptor Type I and
   Oxidative Stress in the Blood of Men with Type II Obesity
SO DISEASE MARKERS
LA English
DT Article
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; LOX-1; INFLAMMATION; TISSUE
AB Objectives. Obesity has serious consequences such as the onset of metabolic syndrome, type 2 diabetes, atherosclerosis, or cardiovascular complications. The aim of this study was to evaluate the levels of paraoxonase 1 (PON1), lectin-like oxidized LDL receptor-1 (LOX-1), antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)), and lipid peroxidation processes in the course of obesity. Methods. 28 men took part in the experiment. Fourteen of them were obese; the control group consisted of 14 physically active men without obesity features. The concentrations of malondialdehyde (MDA), PON1, LOX-1, and tumor necrosis factor alpha (TNF alpha) as well as the activities of erythrocytic SOD, CAT, and GPx were determined in the study. Results. Statistically significant higher MDA, LOX-1, and TNF alpha levels were observed in obese subjects. Conversely, lower concentrations of PON1 in obese men were found. Conclusions. An imbalance in oxidation-reduction processes accompanies obesity. Moreover, inflammatory cytokines and atherosclerotic complications are involved in the obesity process. The obtained results suggest that the studied parameters may be independent prognostic markers preceding the development of cardiovascular and metabolic complications in people afflicted with type II obesity.
C1 [Kupczyk, D.; Bilski, R.; Pawlowska, M.; Wozniak, A.; Szewczyk-Golec, K.] Nicolaus Copernicus Univ Torun, Ludwik Rydygier Coll Med Bydgoszcz, Dept Med Biol & Biochem, Karlowicza 24, PL-85092 Bydgoszcz, Poland.
   [Sokolowski, K.] Family Med Clin Dr Dariusz Gorecki & Partners, Przesmyk 2-4, PL-87100 Torun, Poland.
C3 Nicolaus Copernicus University
RP Bilski, R (corresponding author), Nicolaus Copernicus Univ Torun, Ludwik Rydygier Coll Med Bydgoszcz, Dept Med Biol & Biochem, Karlowicza 24, PL-85092 Bydgoszcz, Poland.
EM rafal.bilski@cm.umk.pl
RI Kupczyk, Daria/P-6159-2015; Pawłowska, Marta/Q-8361-2019; Wozniak,
   Alina/H-4699-2014; Szewczyk-Golec, Karolina/E-9110-2014; Bilski,
   Rafal/P-6170-2015
OI Pawlowska, Marta/0000-0003-1640-9196; Wozniak,
   Alina/0000-0002-4492-4796; Szewczyk-Golec, Karolina/0000-0001-8123-3882;
   Bilski, Rafal/0000-0002-5197-4281; Kupczyk, Daria/0000-0003-1542-0879
CR Agrawal N., 2017, INT J MED HLTH RES, V3, P69
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   [Anonymous], 2009, Obesity and Overweight
   Aviram M, 1998, ARTERIOSCL THROM VAS, V18, P1617, DOI 10.1161/01.ATV.18.10.1617
   BEERS RF, 1952, J BIOL CHEM, V195, P133
   Buege J A, 1978, Methods Enzymol, V52, P302
   Bujalska IJ, 1997, LANCET, V349, P1210, DOI 10.1016/S0140-6736(96)11222-8
   Chen MJ, 2002, PHARMACOL THERAPEUT, V95, P89, DOI 10.1016/S0163-7258(02)00236-X
   Chen MY, 2001, BIOCHEM J, V355, P289, DOI 10.1042/0264-6021:3550289
   Chui PC, 2005, J CLIN INVEST, V115, P2244, DOI 10.1172/JCI24130
   Cook S, 2003, ARCH PEDIAT ADOL MED, V157, P821, DOI 10.1001/archpedi.157.8.821
   Drzycimska-Tatka B., 2011, HYGEIA PUBLIC HLTH, V46, P423
   Durrington PN, 2001, ARTERIOSCL THROM VAS, V21, P473, DOI 10.1161/01.ATV.21.4.473
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   ESTERBAUER H, 1990, METHOD ENZYMOL, V186, P407
   Fülöp P, 2016, CHEM-BIOL INTERACT, V259, P388, DOI 10.1016/j.cbi.2016.04.003
   Gajewski P., 2015, FOLIA CARDIOL, V10, P183
   Göcmen AY, 2012, POSTEP KARDIOL INTER, V8, P199, DOI 10.5114/pwki.2012.30399
   Hamma S A, 2015, J METABOLIC SYND, V4, P188, DOI DOI 10.4172/2167-0943.1000188
   Hashemi M, 2011, EUR J ENDOCRINOL, V164, P219, DOI 10.1530/EJE-10-0881
   James WPT, 2008, J INTERN MED, V263, P336, DOI 10.1111/j.1365-2796.2008.01922.x
   Jung A, 2014, PEDIATR MED RODZ, V10, P226, DOI 10.15557/PiMR.2014.0025
   Kalantari Naser, 2016, ARYA Atheroscler, V12, P281
   Kar K, 2018, J CLIN DIAGN RES, V12, pBC22, DOI 10.7860/JCDR/2018/30771.11936
   Kuge Y, 2008, BIOL PHARM BULL, V31, P1475, DOI 10.1248/bpb.31.1475
   Kulbacka J., 2009, POL MERK LEK, V157, P44
   Maecka-Tendera E., 2007, ACTA PAEDIATR, V94, P543, DOI [10.1111/j.1651-2227.2005.tb01936.x, DOI 10.1111/J.1651-2227.2005.TB01936.X]
   Matsuda M, 2013, OBES RES CLIN PRACT, V7, pE330, DOI 10.1016/j.orcp.2013.05.004
   Mehta JL, 2002, J AM COLL CARDIOL, V39, P1429, DOI 10.1016/S0735-1097(02)01803-X
   Nalwa HS, 2002, J NANOSCI NANOTECHNO, V2
   Nording H, 2016, PLATELETS, V27, P593, DOI 10.3109/09537104.2016.1148807
   Otocka-Kmiecik A, 2009, POSTEP HIG MED DOSW, V63, P668
   PAGLIA DE, 1967, J LAB CLIN MED, V70, P158
   PAOLETTI F, 1990, METHOD ENZYMOL, V186, P209
   Rasouli N, 2009, ARTERIOSCL THROM VAS, V29, P1328, DOI 10.1161/ATVBAHA.109.186957
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   Skalicky J, 2008, CLIN CHEM LAB MED, V46, P499, DOI 10.1515/CCLM.2008.096
   Strzyewski K., 2008, NOWINY LEKARSKIE, V77, P8
   Takanabe-Mori R, 2010, BIOCHEM BIOPH RES CO, V398, P576, DOI 10.1016/j.bbrc.2010.06.123
   Tamakoshi K, 2003, INT J OBESITY, V27, P443, DOI 10.1038/sj.ijo.0802260
   Tinahones FJ, 2009, OBESITY, V17, P240, DOI 10.1038/oby.2008.536
   Van Gaal LF, 1998, ATHEROSCLEROSIS, V137, pS39, DOI 10.1016/S0021-9150(97)00316-X
   Van Guilder GP, 2006, OBESITY, V14, P2127, DOI 10.1038/oby.2006.248
   Vávrová L, 2013, OBESITY FACTS, V6, P39, DOI 10.1159/000348569
   Wang W, 2019, BBA-MOL BASIS DIS, V1865, P1793, DOI 10.1016/j.bbadis.2018.02.009
NR 45
TC 9
Z9 9
U1 0
U2 4
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0278-0240
EI 1875-8630
J9 DIS MARKERS
JI Dis. Markers
PD OCT 15
PY 2019
VL 2019
AR 6178017
DI 10.1155/2019/6178017
PG 7
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine,
   Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research &
   Experimental Medicine; Pathology
GA JH9RR
UT WOS:000493106100001
PM 31737129
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cho, S
   Namkoong, K
   Shin, M
   Park, J
   Yang, E
   Ihm, J
   Thu, VT
   Kim, HK
   Han, J
AF Cho, Sanghyun
   Namkoong, Kyung
   Shin, Minji
   Park, Jueun
   Yang, Eunyeong
   Ihm, Jinsoo
   Vu Thi Thu
   Kim, Hyoung Kyu
   Han, Jin
TI Cardiovascular Protective Effects and Clinical Applications of
   Resveratrol
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Review
DE cardiovascular disease; clinical application; resveratrol
ID IMPROVES ENDOTHELIAL FUNCTION; ACTIVATED PROTEIN-KINASE; OXIDATIVE
   STRESS; METABOLIC SYNDROME; PRIMARY PREVENTION; GENE-EXPRESSION;
   CARDIAC-HYPERTROPHY; FRENCH PARADOX; NITRIC-OXIDE; MITOCHONDRIAL
   BIOGENESIS
AB Resveratrol is a naturally occurring phenol that is generated by plant species following injury or attack by bacterial and fungal pathogens. This compound was first described as the French Paradox in 1992. Later in 2003, resveratrol was reported to activate sirtuins in yeast cells. Recent experimental studies have found that resveratrol offers a variety of benefits that include both anticarcinogenic and anti-inflammatory effects in addition to the ability to reverse obesity, attenuate hyperglycemia and hyperinsulinemia, protect heart and endothelial function, and increase the life span. Multiple molecular targets are associated with the cardioprotective capabilities of resveratrol, and therefore, resveratrol has potential for a wide range of new therapeutic strategies for atherosclerosis, ischemia/ reperfusion, metabolic syndrome, cardiac failure, and inflammatory alterations during aging. Expectations for application in human patients, however, suffer from a lack of sufficient clinical evidence in support of these beneficial effects. This article reviews recently reported basic research results that describe the beneficial effects of resveratrol in an attempt to condense the evidence observed in clinical trials and provide support for the future development of novel clinical therapeutics in patients with cardiovascular diseases.
C1 [Cho, Sanghyun; Namkoong, Kyung; Shin, Minji; Park, Jueun; Yang, Eunyeong; Ihm, Jinsoo; Vu Thi Thu; Kim, Hyoung Kyu; Han, Jin] Inje Univ, Natl Res Lab Mitochondrial Signaling, Cardiovasc & Metab Dis Ctr,Project Team BK21, Dept Hlth Sci & Technol,Dept Physiol,Coll Med, Busan, South Korea.
   [Vu Thi Thu] VNU Univ Sci, Fac Biol, Key Lab Enzyme & Prot Technol, Hanoi, Vietnam.
   [Kim, Hyoung Kyu] Inje Univ, Coll Med, Dept Integrated Biomed Sci, Busan, South Korea.
C3 Inje University; Vietnam National University Hanoi (VNU Hanoi) System;
   VNU University of Science (VNU-HUS); Inje University
RP Kim, HK; Han, J (corresponding author), Inje Univ, Natl Res Lab Mitochondrial Signaling, Cardiovasc & Metab Dis Ctr, Plus Project Team BK21,Dept Physiol,Coll Med, Bokji Ro 75, Busan 47392, South Korea.
EM estrus74@gmail.com; phyhanj@inje.ac.kr
RI Kim, Hyung/J-5451-2012
OI Kim, Hyoung Kyu/0000-0002-1791-7865; Cho, Sanghyun/0009-0006-8591-4654
FU Priority Research Centers Program of the National Research Foundation of
   Korea (NRF) - Ministry of Education, Science and Technology of the
   Republic of Korea [2010-0020224, 2015R1A2A1A13001900, 2015R1D1A1A
   01057937]
FX These investigators were supported by grants (2010-0020224,
   2015R1A2A1A13001900, and 2015R1D1A1A 01057937) from the Priority
   Research Centers Program of the National Research Foundation of Korea
   (NRF), which is funded by the Ministry of Education, Science and
   Technology of the Republic of Korea.
CR Addabbo F, 2009, AM J PATHOL, V174, P34, DOI 10.2353/ajpath.2009.080650
   Adler A, 2003, AM J PHYSIOL-HEART C, V285, pH1015, DOI 10.1152/ajpheart.01047.2002
   Agarwal B, 2013, INT J CARDIOL, V166, P246, DOI 10.1016/j.ijcard.2012.09.027
   [Anonymous], 2009, GLOB HLTH RISKS MORT
   Anton SD, 2014, EXP GERONTOL, V57, P181, DOI 10.1016/j.exger.2014.05.015
   Aviram M, 2004, FREE RADICAL BIO MED, V37, P1304, DOI 10.1016/j.freeradbiomed.2004.06.030
   Bagul PK, 2012, PHARMACOL RES, V66, P260, DOI 10.1016/j.phrs.2012.05.003
   Behbahani J, 2010, AM J HYPERTENS, V23, P1273, DOI 10.1038/ajh.2010.161
   Bentzon JF, 2014, CIRC RES, V114, P1852, DOI 10.1161/CIRCRESAHA.114.302721
   Bhatt JK, 2012, NUTR RES, V32, P537, DOI 10.1016/j.nutres.2012.06.003
   Bo S, 2013, CURR MED CHEM, V20, P1323, DOI 10.2174/0929867311320100009
   Bradamante S, 2003, EUR J PHARMACOL, V465, P115, DOI 10.1016/S0014-2999(03)01441-9
   BROWN MS, 1983, ANNU REV BIOCHEM, V52, P223, DOI 10.1146/annurev.bi.52.070183.001255
   Burgess TA, 2011, ARCH SURG-CHICAGO, V146, P556, DOI 10.1001/archsurg.2011.100
   Carrizzo A, 2013, HYPERTENSION, V62, P359, DOI 10.1161/HYPERTENSIONAHA.111.01009
   Catalgol B, 2012, FRONT PHARMACOL, V3, DOI 10.3389/fphar.2012.00141
   Chan AYM, 2008, J BIOL CHEM, V283, P24194, DOI 10.1074/jbc.M802869200
   Chan AYM, 2004, J BIOL CHEM, V279, P32771, DOI 10.1074/jbc.M403528200
   Chao HH, 2005, EUR J PHARMACOL, V515, P1, DOI 10.1016/j.ejphar.2005.03.035
   Cheng G, 2009, NEUROSCI LETT, V451, P105, DOI 10.1016/j.neulet.2008.12.045
   Chow SE, 2007, J APPL PHYSIOL, V102, P1520, DOI 10.1152/japplphysiol.00881.2006
   Couzin J, 2006, SCIENCE, V311, P755, DOI 10.1126/science.311.5762.755
   Crandall JP, 2012, J GERONTOL A-BIOL, V67, P1307, DOI 10.1093/gerona/glr235
   Csiszar A, 2004, PHYSIOL GENOMICS, V17, P21, DOI 10.1152/physiolgenomics.00136.2003
   Csiszar A, 2002, CIRC RES, V90, P1159, DOI 10.1161/01.RES.0000020401.61826.EA
   Csiszar A, 2008, J APPL PHYSIOL, V105, P1333, DOI 10.1152/japplphysiol.90470.2008
   Csiszar A, 2009, HYPERTENSION, V54, P668, DOI 10.1161/HYPERTENSIONAHA.109.133397
   Csiszar A, 2009, AM J PHYSIOL-HEART C, V297, pH13, DOI 10.1152/ajpheart.00368.2009
   Davignon J, 2004, CIRCULATION, V109, P27, DOI 10.1161/01.CIR.0000131515.03336.f8
   Dolinsky VW, 2013, BBA-MOL BASIS DIS, V1832, P1723, DOI 10.1016/j.bbadis.2013.05.018
   Dolinsky VW, 2009, CIRCULATION, V119, P1643, DOI 10.1161/CIRCULATIONAHA.108.787440
   Donato AJ, 2007, CIRC RES, V100, P1659, DOI 10.1161/01.RES.0000269183.13937.e8
   Elmadhun NY, 2012, SURGERY, V152, P414, DOI 10.1016/j.surg.2012.06.014
   Fan YH, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0105890
   Förstermann U, 2011, BRIT J PHARMACOL, V164, P213, DOI 10.1111/j.1476-5381.2010.01196.x
   Francioso A, 2014, J AGR FOOD CHEM, V62, P1520, DOI 10.1021/jf404155e
   Fujitaka K, 2011, NUTR RES, V31, P842, DOI 10.1016/j.nutres.2011.09.028
   Fukuda S, 2006, CELL BIOCHEM BIOPHYS, V44, P43, DOI 10.1385/CBB:44:1:043
   Fukui M, 2010, FREE RADICAL BIO MED, V49, P800, DOI 10.1016/j.freeradbiomed.2010.06.002
   Fulda S, 2010, DRUG DISCOV TODAY, V15, P757, DOI 10.1016/j.drudis.2010.07.005
   Gambini J, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/837042
   Grundy SM, 2012, J AM COLL CARDIOL, V59, P635, DOI 10.1016/j.jacc.2011.08.080
   Gupta PK, 2014, FOOD SCI NUTR, V2, P218, DOI 10.1002/fsn3.92
   Gurusamy N, 2010, J CELL MOL MED, V14, P2235, DOI 10.1111/j.1582-4934.2010.01140.x
   Hamza SM, 2014, FRONT PHYSIOL, V5, DOI 10.3389/fphys.2014.00292
   Hao EK, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0069452
   He S, 2013, CURR MED CHEM, V20, P1005
   Hector KL, 2012, BIOL LETTERS, V8, P790, DOI 10.1098/rsbl.2012.0316
   Hoffmann J, 2001, CIRC RES, V89, P709, DOI 10.1161/hh2001.097796
   Howitz KT, 2003, NATURE, V425, P191, DOI 10.1038/nature01960
   Huynh K, 2014, PHARMACOL THERAPEUT, V142, P375, DOI 10.1016/j.pharmthera.2014.01.003
   Janowski BA, 1996, NATURE, V383, P728, DOI 10.1038/383728a0
   Jeong SH, 2013, BIOORG MED CHEM LETT, V23, P4225, DOI 10.1016/j.bmcl.2013.05.010
   Johnson JJ, 2011, MOL NUTR FOOD RES, V55, P1169, DOI 10.1002/mnfr.201100117
   Joseph SB, 2002, P NATL ACAD SCI USA, V99, P7604, DOI 10.1073/pnas.112059299
   Juric D, 2007, AM J PHYSIOL-HEART C, V292, pH2138, DOI 10.1152/ajpheart.00852.2006
   Kaur J, 2014, CARDIOL RES PRACT, V2014, DOI 10.1155/2014/943162
   Kearney PM, 2005, LANCET, V365, P217, DOI 10.1016/S0140-6736(05)70151-3
   Kennedy DO, 2010, AM J CLIN NUTR, V91, P1590, DOI 10.3945/ajcn.2009.28641
   Kinlay S, 2001, CIRCULATION, V104, P1114, DOI 10.1161/hc3501.095707
   Kouchak M, 2016, IRAN J PHARM RES, V15, P205
   Lehrke M, 2005, CELL, V123, P993, DOI 10.1016/j.cell.2005.11.026
   Li W, 2004, J MOL CELL CARDIOL, V37, P671, DOI 10.1016/j.yjmcc.2004.05.005
   Lin MT, 2003, MOL PHARMACOL, V64, P1029, DOI 10.1124/mol.64.5.1029
   Liu BL, 2007, CANCER BIOL THER, V6, P1833, DOI 10.4161/cbt.6.12.5161
   Liu FC, 2015, OXID MED CELL LONGEV, V2015, DOI 10.1155/2015/568634
   Liu JC, 2003, HYPERTENSION, V42, P1198, DOI 10.1161/01.HYP.0000103162.76220.51
   Liu YX, 2015, CLIN NUTR, V34, P27, DOI 10.1016/j.clnu.2014.03.009
   Magyar K, 2012, CLIN HEMORHEOL MICRO, V50, P179, DOI 10.3233/CH-2011-1424
   Majdalawieh Amin, 2010, Nucl Recept Signal, V8, pe004, DOI 10.1621/nrs.08004
   Mashhadi FD, 2017, J PHYSIOL SCI, V67, P303, DOI 10.1007/s12576-016-0465-0
   Méndez-del Villar M, 2014, METAB SYNDR RELAT D, V12, P497, DOI 10.1089/met.2014.0082
   Menzies KJ, 2013, J BIOL CHEM, V288, P6968, DOI 10.1074/jbc.M112.431155
   Militaru C, 2013, NUTRITION, V29, P178, DOI 10.1016/j.nut.2012.07.006
   Minotti G, 2004, PHARMACOL REV, V56, P185, DOI 10.1124/pr.56.2.6
   Miyazaki R, 2008, ARTERIOSCL THROM VAS, V28, P1263, DOI 10.1161/ATVBAHA.108.166991
   Moodie DS, 2016, CONGENIT HEART DIS, V11, P213, DOI 10.1111/chd.12383
   Movahed A, 2012, ARCH BIOCHEM BIOPHYS, V527, P74, DOI 10.1016/j.abb.2012.05.002
   Movahed A, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/851267
   Nagy L, 1998, CELL, V93, P229, DOI 10.1016/S0092-8674(00)81574-3
   Noga AA, 2007, AM J PHYSIOL-HEART C, V292, pH1460, DOI 10.1152/ajpheart.01133.2006
   O'Leary KA, 2004, MUTAT RES-FUND MOL M, V551, P245, DOI 10.1016/j.mrfmmm.2004.01.015
   Osman AMM, 2012, CANCER CELL INT, V12, DOI 10.1186/1475-2867-12-47
   Pangeni R, 2014, EXPERT OPIN DRUG DEL, V11, P1285, DOI 10.1517/17425247.2014.919253
   Parikh Rakesh M, 2012, Indian J Endocrinol Metab, V16, P7, DOI 10.4103/2230-8210.91175
   Pearson KJ, 2008, CELL METAB, V8, P157, DOI 10.1016/j.cmet.2008.06.011
   Poulsen MM, 2013, DIABETES, V62, P1186, DOI 10.2337/db12-0975
   Raj P, 2016, J NUTR BIOCHEM, V28, P155, DOI 10.1016/j.jnutbio.2015.09.025
   RENAUD S, 1992, LANCET, V339, P1523, DOI 10.1016/0140-6736(92)91277-F
   Robich MP, 2011, EUR J PHARMACOL, V664, P45, DOI 10.1016/j.ejphar.2011.04.059
   Ross R, 1999, NEW ENGL J MED, V340, P115, DOI 10.1056/NEJM199901143400207
   Ruan BF, 2012, CURR MED CHEM, V19, P4175, DOI 10.2174/092986712802430054
   Rubbo H, 2002, METHOD ENZYMOL, V359, P200
   Sahebkar A, 2013, NUTR REV, V71, P822, DOI 10.1111/nure.12081
   Selvetella G, 2004, CARDIOVASC RES, V63, P373, DOI 10.1016/j.cardiores.2004.04.031
   Sevov M, 2006, BIOCHEM BIOPH RES CO, V348, P1047, DOI 10.1016/j.bbrc.2006.07.155
   Smoliga JM, 2013, AGING-US, V5, P495, DOI 10.18632/aging.100579
   Smoliga JM, 2012, J GERONTOL A-BIOL, V67, P158, DOI 10.1093/gerona/glr062
   Smulyan H, 2016, J AM SOC HYPERTENS, V10, P175, DOI 10.1016/j.jash.2015.11.012
   Soare A, 2013, AGING-US, V4, P4
   Stocker R, 2006, CIRCULATION, V114, P2178, DOI 10.1161/CIRCULATIONAHA.105.598698
   Tang Guanmin, 2016, Exp Mol Pathol, DOI 10.1016/j.yexmp.2016.10.005
   Thandapilly SJ, 2010, AM J HYPERTENS, V23, P192, DOI 10.1038/ajh.2009.228
   Thirunavukkarasu M, 2007, FREE RADICAL BIO MED, V43, P720, DOI 10.1016/j.freeradbiomed.2007.05.004
   Timmers S, 2011, CELL METAB, V14, P612, DOI 10.1016/j.cmet.2011.10.002
   Tomé-Carneiro J, 2013, CARDIOVASC DRUG THER, V27, P37, DOI 10.1007/s10557-012-6427-8
   Tomé-Carneiro J, 2012, AM J CARDIOL, V110, P356, DOI 10.1016/j.amjcard.2012.03.030
   Tomé-Carneiro J, 2012, MOL NUTR FOOD RES, V56, P810, DOI 10.1002/mnfr.201100673
   Ungvari Z, 2008, AM J PHYSIOL-HEART C, V294, pH2121, DOI 10.1152/ajpheart.00012.2008
   Ungvari Z, 2007, AM J PHYSIOL-HEART C, V293, pH37, DOI 10.1152/ajpheart.01346.2006
   Ungvari Z, 2009, AM J PHYSIOL-HEART C, V297, pH1876, DOI 10.1152/ajpheart.00375.2009
   van der Loo B, 2000, J EXP MED, V192, P1731, DOI 10.1084/jem.192.12.1731
   Varga ZV, 2015, BBA-MOL BASIS DIS, V1852, P232, DOI 10.1016/j.bbadis.2014.06.030
   Vidavalur Ramesh, 2006, Exp Clin Cardiol, V11, P217
   Voloshyna I, 2013, EUR J PHARMACOL, V698, P299, DOI 10.1016/j.ejphar.2012.08.024
   Voloshyna I, 2012, J MED FOOD, V15, P763, DOI 10.1089/jmf.2012.0025
   Voloshyna I, 2011, PROG LIPID RES, V50, P213, DOI 10.1016/j.plipres.2011.02.001
   Wadsworth TL, 1999, BIOCHEM PHARMACOL, V57, P941, DOI 10.1016/S0006-2952(99)00002-7
   Wang B, 2014, J CELL MOL MED, V18, P1599, DOI 10.1111/jcmm.12312
   Wightman EL, 2014, BRIT J NUTR, V112, P203, DOI 10.1017/S0007114514000737
   Wong RHX, 2011, NUTR METAB CARDIOVAS, V21, P851, DOI 10.1016/j.numecd.2010.03.003
   Wong RHX, 2013, J HYPERTENS, V31, P1819, DOI 10.1097/HJH.0b013e328362b9d6
   Wu H, 2016, BMC CARDIOVASC DISOR, V16, DOI 10.1186/s12872-015-0169-z
   Yang B, 2016, EUR REV MED PHARMACO, V20, P2734
   Yin K, 2015, CELL PHYSIOL BIOCHEM, V35, P2451, DOI 10.1159/000374045
   Yoshino J, 2012, CELL METAB, V16, P658, DOI 10.1016/j.cmet.2012.09.015
   Zhang HR, 2010, AM J PHYSIOL-HEART C, V299, pH985, DOI 10.1152/ajpheart.00489.2010
   Zhang HR, 2009, ARTERIOSCL THROM VAS, V29, P1164, DOI 10.1161/ATVBAHA.109.187146
   Zordoky BNM, 2015, BBA-MOL BASIS DIS, V1852, P1155, DOI 10.1016/j.bbadis.2014.10.016
   Zou JG, 2003, INT J MOL MED, V11, P317
NR 130
TC 70
Z9 76
U1 2
U2 40
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD APR
PY 2017
VL 20
IS 4
BP 323
EP 334
DI 10.1089/jmf.2016.3856
PG 12
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA ES4HU
UT WOS:000399494700001
PM 28346848
DA 2025-06-11
ER

PT J
AU Laight, DW
AF Laight, DW
TI Therapeutic approaches to the management of dysmetabolic cardiovascular
   disease
SO EXPERT OPINION ON THERAPEUTIC PATENTS
LA English
DT Review
DE antioxidants; atherosclerosis; dysglycaemia; dyslipidaemia; endothelium;
   insulin resistance; nitric oxide; obesity; oxidant stress; syndrome X;
   Type 2 diabetes
ID ACTIVATED RECEPTOR-GAMMA; INSULIN-RESISTANCE; DIABETES-MELLITUS;
   DOUBLE-BLIND; WEIGHT-LOSS; RISK-FACTORS; PREVENTION; ORLISTAT; ACARBOSE;
   ABNORMALITIES
AB Metabolic abnormalities, such as impaired insulin sensitivity, hyperinsulinaemia, dysglycaemia and dyslipidaemia, often encountered ensemble in syndrome X, are acknowledged risk factors for cardiovascular disease that may play significant roles in the accelerated development of macrovascular disease associated with insulin resistance and Type 2 diabetes. Indeed, just as tight glycaemic control has alleviated diabetic microangiopathy, there is now a possibility that targeting the proposed fundamental feature of syndromeX, insulin resistance, will play a leading part, in not only preventing Type 2 diabetes, but also in reducing the burden of both prediabetic and diabetic macrovascular disease. This may be optimally achieved with multiple risk factor interventions that improve insulin sensitivity and modify traditional and newly described dysmetabolic and pro-atherogenic factors.
C1 Univ Portsmouth, Sch Pharm & Biomed Sci, Portsmouth PO1 2DT, Hants, England.
C3 University of Portsmouth
RP Univ Portsmouth, Sch Pharm & Biomed Sci, White Swan Rd, Portsmouth PO1 2DT, Hants, England.
EM David.Laight@port.ac.uk
CR Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
   AM CYANAMID CO, 2000, Patent No. 0044710
   AM HOME PRODUCTS COR, 2000, Patent No. 6103798
   AM HOME PRODUCTS COR, 2001, Patent No. 6110963
   ANDERSEN HS, 2001, Patent No. 00117516
   ASTRAZENECA AB, 2001, Patent No. 0102364
   AVENTIS PHARM PRODUC, 2000, Patent No. 00064876
   AVENTIS PHARMA DEUTS, 2000, Patent No. 0009496
   Bailey C J., 2001, The British Journal of Diabetes Vascular Disease, V1, P7
   BASF AG, 2000, Patent No. 0119828
   Berg AH, 2002, TRENDS ENDOCRIN MET, V13, P84, DOI 10.1016/S1043-2760(01)00524-0
   Bhagwat S. S., 2000, PCT Int. Appl. WO 0055137, Patent No. 0055137
   BRISTOLMYERS SQUIBB, 2001, Patent No. 0113917
   Burnett TR, 2001, DIABETES OBES METAB, V3, P143, DOI 10.1046/j.1463-1326.2001.00155.x
   Calles-Escandon J, 1999, CORONARY ARTERY DIS, V10, P23, DOI 10.1097/00019501-199901000-00004
   Campbell IW, 2000, DRUGS, V60, P1017, DOI 10.2165/00003495-200060050-00004
   Ceriello A, 2001, EUR J CLIN INVEST, V31, P322, DOI 10.1046/j.1365-2362.2001.00818.x
   Citroën HA, 2000, DIABETOLOGIA, V43, pA73
   CNRS, 2000, Patent No. 0073266
   CNRS, 2001, Patent No. 0115689
   DOLLINGS PJ, 2000, Patent No. 6063815
   E LILLY CO, 2001, Patent No. 0116120
   Egan BM, 2001, AM J HYPERTENS, V14, p116S, DOI 10.1016/S0895-7061(01)02078-7
   ENDORECHERCHE INC, 2001, Patent No. 010969
   Feldt-Rasmussen B, 2000, DIABETES METAB, V26, P64
   Flanagan DEH, 2000, EUR J CLIN INVEST, V30, P297
   Fujimoto WY, 2000, DIABETES CARE, V23, pB11
   Golay A, 2000, EUR J CLIN INVEST, V30, P12, DOI 10.1046/j.1365-2362.30.s2.3.x
   Groop L, 1996, DIABETES, V45, P1585, DOI 10.2337/diabetes.45.11.1585
   Groop L, 2001, J INTERN MED, V250, P105, DOI 10.1046/j.1365-2796.2001.00864.x
   Halimi S, 2000, DIABETES RES CLIN PR, V50, P49, DOI 10.1016/S0168-8227(00)00163-7
   HANEFELD M, 1991, DIABETES CARE, V14, P732, DOI 10.2337/diacare.14.8.732
   HARGREAVES RB, 2001, Patent No. 0112612
   Hasche H, 1999, DIABETES NUTR METAB, V12, P277
   HECK A, 2000, NATURE, V404, P672
   Heymsfield SB, 2000, ARCH INTERN MED, V160, P1321, DOI 10.1001/archinte.160.9.1321
   HODSON HF, 2000, Patent No. 00040569
   Hollander PA, 1998, DIABETES CARE, V21, P1288, DOI 10.2337/diacare.21.8.1288
   Imano E, 1998, DIABETES CARE, V21, P2135, DOI 10.2337/diacare.21.12.2135
   KARABELAS K, 2000, Patent No. 0078750
   KESIS PHARM INC, 2001, Patent No. 0103700
   King P, 1999, BRIT J CLIN PHARMACO, V48, P643, DOI 10.1046/j.1365-2125.1999.00092.x
   Kirpichnikov D, 2001, TRENDS ENDOCRIN MET, V12, P225, DOI 10.1016/S1043-2760(01)00391-5
   KOLB HC, 2000, Patent No. 0063161
   Laight DW, 1999, DIABETES-METAB RES, V15, P274, DOI 10.1002/(SICI)1520-7560(199907/08)15:4<274::AID-DMRR46>3.0.CO;2-G
   Laight DW, 2001, EXPERT OPIN THER PAT, V11, P999, DOI 10.1517/13543776.11.6.999
   Laight DW, 2000, EXPERT OPIN THER PAT, V10, P1703, DOI 10.1517/13543776.10.11.1703
   Laight DW, 2000, CARDIOVASC RES, V47, P457, DOI 10.1016/S0008-6363(00)00054-7
   LAIGHT DW, 2001, FUTURE PRESCRIBER, V2, P12
   LAIGHT DW, 2001, FUTURE PRESCRIBER, V11, P999
   LAIGHT DW, 2001, CARDIABETES, V1, P39
   LIGAND PHARM INC, 2001, Patent No. 0119770
   Malamas MS, 2000, J MED CHEM, V43, P995, DOI 10.1021/jm990476x
   Mauvais-Jarvis F, 2001, DIABETES METAB, V27, P415
   MAXIA PHARM INC, 2001, Patent No. 0116122
   MERCK PATENT GMBH, 2000, Patent No. 0025795
   MOUNT SINAI HOSP, 2000, Patent No. 0007575
   Nicholas SB, 2001, HYPERTENSION, V37, P722, DOI 10.1161/01.HYP.37.2.722
   NOVO NORDISK AS, 2000, Patent No. 0023415
   ORTHO MCNEIL PHARM I, 2000, Patent No. 0069847
   Patel V, 2001, BR J DIABETES VASC D, DOI [10.1177/14746514010010010701, DOI 10.1177/14746514010010010701]
   PFIZER PRODUCTS INC, 2001, Patent No. 1092431
   Proietto J, 2000, EXPERT OPIN INV DRUG, V9, P1317, DOI 10.1517/13543784.9.6.1317
   Rao G, 2001, AM FAM PHYSICIAN, V63, P1159
   Rett K, 1999, DIABETES OBES METAB, V1, pS8, DOI 10.1046/j.1463-1326.1999.0010s1008.x
   Rössner S, 2000, OBES RES, V8, P49, DOI 10.1038/oby.2000.8
   Sidhu JS, 2001, HEART, V86, P255
   Sjöström L, 1998, LANCET, V352, P167, DOI 10.1016/S0140-6736(97)11509-4
   Stearne MR, 1998, BMJ-BRIT MED J, V317, P703
   Stears AJ, 2001, DIABETES OBES METAB, V3, P129, DOI 10.1046/j.1463-1326.2001.00151.x
   Steppan CM, 2001, NATURE, V409, P307, DOI 10.1038/35053000
   Summers LKM, 1999, ATHEROSCLEROSIS, V147, P11, DOI 10.1016/S0021-9150(99)00172-0
   Sunayama S, 2000, CURR OPIN LIPIDOL, V11, P397, DOI 10.1097/00041433-200008000-00009
   Turner RC, 1998, LANCET, V352, P854, DOI 10.1016/s0140-6736(98)07037-8
   Turner RC, 1998, LANCET, V352, P837, DOI 10.1016/s0140-6736(98)07019-6
   Uusitupa M, 2000, BRIT J NUTR, V83, pS137
   Vergès BL, 1999, DIABETES METAB, V25, P32
   Vidal-Puig A, 2001, CLIN ENDOCRINOL, V55, P437, DOI 10.1046/j.1365-2265.2001.01377.x
   Way KJ, 2001, DIABETIC MED, V18, P945, DOI 10.1046/j.0742-3071.2001.00638.x
   WILD S, 2001, CARDIABETES, V1, P20
   WROBEL J, 2000, Patent No. 6057316
   Yang WS, 2002, DIABETES CARE, V25, P376, DOI 10.2337/diacare.25.2.376
   Yusuf S, 2001, EUR HEART J, V22, P103, DOI 10.1053/euhj.2000.2459
   Yusuf S, 2000, NEW ENGL J MED, V342, P145
   Zimmet P, 2001, NATURE, V414, P782, DOI 10.1038/414782a
   ZIMMET P, 2000, ANN NY ACAD SCI, V892, P25
   2000, Patent No. [0001679, 001679]
   2000, Patent No. 0008002
NR 88
TC 2
Z9 2
U1 0
U2 0
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1354-3776
EI 1744-7674
J9 EXPERT OPIN THER PAT
JI Expert Opin. Ther. Patents
PD MAY
PY 2002
VL 12
IS 5
BP 615
EP 620
DI 10.1517/13543776.12.5.615
PG 6
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 553BT
UT WOS:000175656200001
DA 2025-06-11
ER

PT J
AU Kanda, T
   Goto, T
   Hirotsu, Y
   Masuzaki, R
   Moriyama, M
   Omata, M
AF Kanda, Tatsuo
   Goto, Taichiro
   Hirotsu, Yosuke
   Masuzaki, Ryota
   Moriyama, Mitsuhiko
   Omata, Masao
TI Molecular Mechanisms: Connections between Nonalcoholic Fatty Liver
   Disease, Steatohepatitis and Hepatocellular Carcinoma
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE dysbiosis; HCC; HSD17B13; NAFLD; NASH; metabolic syndrome; microbiota;
   obesity; PNPLA3
ID INTESTINAL BACTERIAL OVERGROWTH; FIBROSIS PROGRESSION; AMERICAN
   ASSOCIATION; INSULIN-RESISTANCE; OXIDATIVE STRESS; UNITED-STATES;
   PLASMA-LEVELS; BILE-ACIDS; OBESITY; PROTEIN
AB Nonalcoholic fatty liver disease (NAFLD), including nonalcoholic steatohepatitis (NASH), causes hepatic fibrosis, cirrhosis and hepatocellular carcinoma (HCC). The patatin-like phospholipase-3 (PNPLA3) I148M sequence variant is one of the strongest genetic determinants of NAFLD/NASH. PNPLA3 is an independent risk factor for HCC among patients with NASH. The obesity epidemic is closely associated with the rising prevalence and severity of NAFLD/NASH. Furthermore, metabolic syndrome exacerbates the course of NAFLD/NASH. These factors are able to induce apoptosis and activate immune and inflammatory pathways, resulting in the development of hepatic fibrosis and NASH, leading to progression toward HCC. Small intestinal bacterial overgrowth (SIBO), destruction of the intestinal mucosa barrier function and a high-fat diet all seem to exacerbate the development of hepatic fibrosis and NASH, leading to HCC in patients with NAFLD/NASH. Thus, the intestinal microbiota may play a role in the development of NAFLD/NASH. In this review, we describe recent advances in our knowledge of the molecular mechanisms contributing to the development of hepatic fibrosis and HCC in patients with NAFLD/NASH.
C1 [Kanda, Tatsuo; Masuzaki, Ryota; Moriyama, Mitsuhiko] Nihon Univ, Div Gastroenterol & Hepatol, Dept Med, Sch Med,Itabashi Ku, 30-1 Oyaguchi Kamicho, Tokyo 1738610, Japan.
   [Goto, Taichiro] Yamanashi Cent Hosp, Lung Canc & Resp Dis Ctr, 1-1-1 Fujimi, Kofu, Yamanashi 4008506, Japan.
   [Hirotsu, Yosuke; Omata, Masao] Yamanashi Cent Hosp, Genome Anal Ctr, Yamanashi 4008506, Japan.
   [Omata, Masao] Univ Tokyo, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
C3 Nihon University; University of Tokyo
RP Goto, T (corresponding author), Yamanashi Cent Hosp, Lung Canc & Resp Dis Ctr, 1-1-1 Fujimi, Kofu, Yamanashi 4008506, Japan.
EM kanda2t@yahoo.co.jp; taichiro@1997.jukuin.keio.ac.jp;
   hirotsu-bdyu@ych.pref.yamanashi.jp; masuzaki.ryota@nihon-u.ac.jp;
   moriyama.mitsuhiko@nihon-u.ac.jp; m-omata0901@ych.pref.yamanashi.jp
RI Yosuke, Hirotsu/IQR-4402-2023; Goto, Taichiro/AAM-5276-2020; Kanda,
   Tatsuo/AFA-8767-2022
OI Kanda, Tatsuo/0000-0002-1654-5385; Hirotsu, Yosuke/0000-0002-8002-834X;
   Kanda, Tatsuo/0009-0000-8135-342X; Goto, Taichiro/0000-0002-2560-3639
FU JSPS KAKENHI [17K09404]; Grants-in-Aid for Scientific Research
   [17K09404] Funding Source: KAKEN
FX This work was partly supported by JSPS KAKENHI grant number 17K09404 (to
   T.K.).
CR Abdelmegeed MA, 2013, FREE RADICAL BIO MED, V65, P1238, DOI 10.1016/j.freeradbiomed.2013.09.009
   Abu Shanab A, 2011, DIGEST DIS SCI, V56, P1524, DOI 10.1007/s10620-010-1447-3
   Abul-Husn NS, 2018, NEW ENGL J MED, V378, P1096, DOI 10.1056/NEJMoa1712191
   Adams LA, 2005, GASTROENTEROLOGY, V129, P113, DOI 10.1053/j.gastro.2005.04.014
   Akiyama K, 2018, EXP ANIM TOKYO, V67, P201, DOI 10.1538/expanim.17-0112
   Al-Azzawi Y, 2019, J CANCER EPIDEMIOL, V2019, DOI 10.1155/2019/8534372
   Alexander M, 2019, BMC MED, V17, DOI 10.1186/s12916-019-1321-x
   Angulo P, 1999, HEPATOLOGY, V30, P1356, DOI 10.1002/hep.510300604
   Anstee QM, 2019, NAT REV GASTRO HEPAT, V16, P411, DOI 10.1038/s41575-019-0145-7
   Aslam MN, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0166178
   Bluemel S, 2018, HEPATOL COMMUN, V2, P393, DOI 10.1002/hep4.1165
   Browning JD, 2004, AM J GASTROENTEROL, V99, P292, DOI 10.1111/j.1572-0241.2004.04059.x
   Browning JD, 2004, J CLIN INVEST, V114, P147, DOI 10.1172/JCI200422422
   Brunner KT, 2019, CURR OBES REP, V8, P220, DOI 10.1007/s13679-019-00345-1
   Brunt EM, 1999, AM J GASTROENTEROL, V94, P2467, DOI 10.1111/j.1572-0241.1999.01377.x
   Caldwell SH, 2002, AM J GASTROENTEROL, V97, P1496, DOI 10.1016/S0002-9270(02)04151-5
   Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI 10.1002/hep.29367
   Chalasani N, 2012, HEPATOLOGY, V55, P2005, DOI 10.1002/hep.25762
   Chen J, 2018, HEPATOB PANCREAT DIS, V17, P220, DOI 10.1016/j.hbpd.2018.04.006
   Da Silva HE, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-19753-9
   Desterke C, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20225594
   Du XH, 2019, CELL MOL IMMUNOL, V16, P878, DOI 10.1038/s41423-018-0032-0
   Duparc T, 2017, GUT, V66, P620, DOI 10.1136/gutjnl-2015-310904
   Dyson J, 2014, J HEPATOL, V60, P110, DOI 10.1016/j.jhep.2013.08.011
   EASL, 2016, OBESITY FACTS, V9, P65, DOI [10.1159/000443344, 10.1007/s00125-016-3902-y, 10.1016/j.jhep.2015.11.004]
   Elinav E, 2011, CELL, V145, P745, DOI 10.1016/j.cell.2011.04.022
   Enomoto H, 2020, J GASTROENTEROL, V55, P353, DOI 10.1007/s00535-019-01645-y
   Finck BN, 2018, DIABETES, V67, P2485, DOI 10.2337/dbi18-0024
   Ganz M, 2013, HEPATOL INT, V7, pS771, DOI 10.1007/s12072-013-9468-6
   García-Lezana T, 2018, HEPATOLOGY, V67, P1485, DOI 10.1002/hep.29646
   Gentric G, 2015, J CLIN INVEST, V125, P981, DOI 10.1172/JCI73957
   Gomez-Santos L, 2012, HEPATOLOGY, V56, P747, DOI 10.1002/hep.25694
   Guo Y, 2016, J GASTROENTEROL, V51, P1022, DOI 10.1007/s00535-016-1178-0
   Handa P, 2016, AM J PHYSIOL-GASTR L, V310, pG117, DOI 10.1152/ajpgi.00246.2015
   Hashimoto E, 2013, J GASTROEN HEPATOL, V28, P64, DOI 10.1111/jgh.12271
   Henao-Mejia J, 2012, NATURE, V482, P179, DOI 10.1038/nature10809
   Higuchi Teruhisa, 2018, Oncotarget, V9, P26183, DOI 10.18632/oncotarget.25488
   Jelenik T, 2017, DIABETES, V66, P2241, DOI 10.2337/db16-1147
   Ji F, 2019, AGING-US, V11, P7847, DOI 10.18632/aging.102293
   Kanda T, 2005, EUR J PEDIATR, V164, P212, DOI 10.1007/s00431-004-1584-9
   Kanda T, 2008, J VIROL, V82, P11066, DOI 10.1128/JVI.01300-08
   Kanda T, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20061358
   Kanda T, 2018, WORLD J GASTROENTERO, V24, P2661, DOI 10.3748/wjg.v24.i25.2661
   Kapil S, 2016, J GASTROEN HEPATOL, V31, P213, DOI 10.1111/jgh.13058
   Kawaguchi T, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0185490
   Kawaguchi T, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038322
   Kazankov K, 2019, NAT REV GASTRO HEPAT, V16, P145, DOI 10.1038/s41575-018-0082-x
   Kim JY, 2018, CELL, V175, P133, DOI 10.1016/j.cell.2018.08.020
   Kishida Y, 2017, J GASTROENTEROL, V52, P1180, DOI 10.1007/s00535-017-1331-4
   Kitade H, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040387
   Kleiner DE, 2019, JAMA NETW OPEN, V2, DOI 10.1001/jamanetworkopen.2019.12565
   Kudo M, 2020, HEPATOL RES, V50, P15, DOI 10.1111/hepr.13438
   Kuramoto J, 2017, CARCINOGENESIS, V38, P261, DOI 10.1093/carcin/bgx005
   Le Roy T, 2013, GUT, V62, P1787, DOI 10.1136/gutjnl-2012-303816
   Lee SS, 2013, BMC CANCER, V13, DOI 10.1186/1471-2407-13-335
   Li CW, 2018, DIS MARKERS, V2018, DOI 10.1155/2018/8635329
   Li S, 2008, WORLD J GASTROENTERO, V14, P3254, DOI 10.3748/wjg.14.3254
   Liu JX, 2019, MED SCI MONITOR, V25, P1078, DOI 10.12659/MSM.912737
   Liu YL, 2014, J HEPATOL, V61, P75, DOI 10.1016/j.jhep.2014.02.030
   LUDWIG J, 1980, MAYO CLIN PROC, V55, P434
   Ludwig J, 1997, J GASTROEN HEPATOL, V12, P398, DOI 10.1111/j.1440-1746.1997.tb00450.x
   Lumeng CN, 2011, J CLIN INVEST, V121, P2111, DOI 10.1172/JCI57132
   Ma YY, 2013, WORLD J GASTROENTERO, V19, P6911, DOI 10.3748/wjg.v19.i40.6911
   Ma YL, 2019, HEPATOLOGY, V69, P1504, DOI 10.1002/hep.30350
   Matsushita N, 2016, SCAND J IMMUNOL, V83, P109, DOI 10.1111/sji.12397
   Matteoni CA, 1999, GASTROENTEROLOGY, V116, P1413, DOI 10.1016/S0016-5085(99)70506-8
   Miele L, 2009, HEPATOLOGY, V49, P1877, DOI 10.1002/hep.22848
   Mittal S, 2016, CLIN GASTROENTEROL H, V14, P124, DOI 10.1016/j.cgh.2015.07.019
   Mohs A, 2020, CARCINOGENESIS, V41, P171, DOI 10.1093/carcin/bgy173
   Mouries J, 2019, J HEPATOL, V71, P1216, DOI 10.1016/j.jhep.2019.08.005
   Mouzaki M, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0151829
   Mouzaki M, 2013, HEPATOLOGY, V58, P120, DOI 10.1002/hep.26319
   Nair S, 2001, AM J GASTROENTEROL, V96, P1200, DOI 10.1111/j.1572-0241.2001.03702.x
   Nakano M, 2013, GASTROENTEROL RES, V6, P17, DOI 10.4021/gr513w
   Namjou B, 2019, BMC MED, V17, DOI 10.1186/s12916-019-1364-z
   Okubo H, 2015, AM J PHYSIOL-GASTR L, V308, pG151, DOI 10.1152/ajpgi.00198.2014
   Pang J, 2017, ALIMENT PHARM THER, V46, P175, DOI 10.1111/apt.14119
   Pirola CJ, 2019, J LIPID RES, V60, P176, DOI 10.1194/jlr.P089953
   Polyzos SA, 2019, METABOLISM, V92, P82, DOI 10.1016/j.metabol.2018.11.014
   Rahman K, 2016, GASTROENTEROLOGY, V151, P733, DOI 10.1053/j.gastro.2016.06.022
   Ratziu V, 2019, LANCET, V394, P1970, DOI 10.1016/S0140-6736(19)32731-X
   Reid DT, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0159524
   Romeo S, 2010, INT J OBESITY, V34, P190, DOI 10.1038/ijo.2009.216
   Romeo S, 2008, NAT GENET, V40, P1461, DOI 10.1038/ng.257
   Sasaki R, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20061406
   Schwimmer JB, 2019, GASTROENTEROLOGY, V157, P1109, DOI 10.1053/j.gastro.2019.06.028
   Sheldon RD, 2019, AM J PHYSIOL-ENDOC M, V317, pE605, DOI 10.1152/ajpendo.00096.2019
   Shimada M, 2002, J HEPATOL, V37, P154, DOI 10.1016/S0168-8278(02)00099-5
   Singal AG, 2014, AM J GASTROENTEROL, V109, P325, DOI 10.1038/ajg.2013.476
   Söderberg C, 2011, APMIS, V119, P412, DOI 10.1111/j.1600-0463.2011.02746.x
   Sohn W, 2015, DIGEST DIS SCI, V60, P3340, DOI 10.1007/s10620-015-3770-1
   Su W, 2014, P NATL ACAD SCI USA, V111, P11437, DOI 10.1073/pnas.1410741111
   Sun GY, 2018, CELL REP, V25, P3786, DOI 10.1016/j.celrep.2018.12.006
   Sun HY, 2018, NAT COMMUN, V9, DOI 10.1038/s41467-018-07402-8
   Tsujimoto T, 2012, DIGEST DIS SCI, V57, P1144, DOI 10.1007/s10620-012-2073-z
   Ueyama M, 2016, J GASTROENTEROL, V51, P370, DOI 10.1007/s00535-015-1116-6
   Wada N, 2017, HEPATOL INT, V11, P115, DOI 10.1007/s12072-016-9773-y
   Wan XY, 2016, CAN J GASTROENTEROL, V2016, DOI 10.1155/2016/6489012
   Wieckowska A, 2006, HEPATOLOGY, V44, P27, DOI 10.1002/hep.21223
   Wigg AJ, 2001, GUT, V48, P206, DOI 10.1136/gut.48.2.206
   Wilson PA, 2006, J LIPID RES, V47, P1940, DOI 10.1194/jlr.M600185-JLR200
   Wong VWS, 2015, ALIMENT PHARM THER, V42, P731, DOI 10.1111/apt.13327
   Wong VWS, 2018, J GASTROEN HEPATOL, V33, P70, DOI 10.1111/jgh.13857
   Wu WC, 2008, WORLD J GASTROENTERO, V14, P313, DOI 10.3748/wjg.14.313
   Xie GX, 2016, INT J CANCER, V139, P1764, DOI 10.1002/ijc.30219
   Xu M, 2019, ANN HEPATOL, V18, P456, DOI 10.1016/j.aohep.2018.10.005
   Yang J, 2019, HEPATOLOGY, V70, P231, DOI 10.1002/hep.30623
   Yasui K, 2011, CLIN GASTROENTEROL H, V9, P428, DOI 10.1016/j.cgh.2011.01.023
   Yatsuji S, 2009, J GASTROEN HEPATOL, V24, P248, DOI 10.1111/j.1440-1746.2008.05640.x
   Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431
   Younossi ZM, 2015, HEPATOLOGY, V62, P1723, DOI 10.1002/hep.28123
   Yuan JY, 2014, J GASTROEN HEPATOL, V29, P1292, DOI 10.1111/jgh.12510
   Yuan X, 2008, AM J HUM GENET, V83, P520, DOI 10.1016/j.ajhg.2008.09.012
   Zhao ZH, 2019, EXP MOL MED, V51
   Zhou D, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-01751-y
NR 115
TC 72
Z9 73
U1 3
U2 59
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB
PY 2020
VL 21
IS 4
AR 1525
DI 10.3390/ijms21041525
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA KY4FE
UT WOS:000522524400352
PM 32102237
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Carnagarin, R
   Carlessi, R
   Newsholme, P
   Dharmarajan, AM
   Dass, CR
AF Carnagarin, Revathy
   Carlessi, Rodrigo
   Newsholme, Philip
   Dharmarajan, Arun M.
   Dass, Crispin R.
TI Pigment epithelium-derived factor stimulates skeletal muscle glycolytic
   activity through NADPH oxidase-dependent reactive oxygen species
   production
SO INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
LA English
DT Article
DE PEDF; Skeletal muscle; Reactive oxygen species; Glycolysis;
   Antioxidants; NADPH oxidase
ID ADIPOSE TRIGLYCERIDE LIPASE; INDUCED OXIDATIVE STRESS; FACTOR PEDF;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; SERUM-LEVELS; CELLS; CANCER;
   DIFFERENTIATION; IDENTIFICATION
AB Pigment epithelium-derived factor is a multifunctional serpin implicated in insulin resistance in metabolic disorders. Recent evidence suggests that exposure of peripheral tissues such as skeletal muscle to PEDF has profound metabolic consequences with predisposition towards chronic conditions such as obesity, type 2 diabetes, metabolic syndrome and polycystic ovarian syndrome. Chronic inflammation shifts muscle metabolism towards increased glycolysis and decreased oxidative metabolism. In the present study, we demonstrate a novel effect of PEDF on cellular metabolism in mouse cell line (C2C12) and human primary skeletal muscle cells. PEDF addition to skeletal muscle cells induced enhanced phospholipase A2 activity. This was accompanied with increased production of reactive oxygen species in a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-dependent manner that triggered a shift towards a more glycolytic phenotype. Extracellular flux analysis and glucose consumption assays demonstrated that PEDF treatment resulted in enhanced glycolysis but did not change mitochondrial respiration. Our results demonstrate that skeletal muscle cells express a PEDF-inducible oxidant generating system that enhances glycolysis but is sensitive to antioxidants and NADPH oxidase inhibition. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Carnagarin, Revathy; Carlessi, Rodrigo; Newsholme, Philip; Dharmarajan, Arun M.; Dass, Crispin R.] Curtin Hlth Innovat Res Inst, Bentley, WA 6102, Australia.
   [Carnagarin, Revathy; Dass, Crispin R.] Curtin Univ, Sch Pharm, Bentley, WA 6102, Australia.
   [Carnagarin, Revathy; Dharmarajan, Arun M.] Curtin Univ, Sch Biomed Sci, Stem Cell & Canc Biol Lab, Bentley, WA 6102, Australia.
   [Carnagarin, Revathy; Carlessi, Rodrigo; Newsholme, Philip] Curtin Univ, Sch Biomed Sci, Bentley, WA 6102, Australia.
C3 Curtin University; Curtin University; Curtin University
RP Dass, CR (corresponding author), Curtin Univ, Sch Pharm, GPO Box U1987, Perth, WA 6845, Australia.
EM Crispin.Dass@curtin.edu.au
RI Newsholme, Philip/D-4939-2016; Carlessi, Rodrigo/JCE-0678-2023
OI Carlessi, Rodrigo/0000-0003-0038-7391; Dharmarajan,
   Arun/0000-0002-6715-6005; Carnagarin, Revathy/0000-0003-4714-0206; Dass,
   Crispin/0000-0001-7087-7957
FU International Postgraduate Research Scholarship (IPRS) at Curtin
   University; Curtin Academic50
FX The authors acknowledge support provided by the International
   Postgraduate Research Scholarship (IPRS) at Curtin University to RC, and
   Curtin Academic50 support to CRD, and Dr Pat Methoram and Dr Younan Chen
   for various reagents and experimental advice.
CR Alcantara MB, 2014, J PHARM PHARMACOL, V66, P895, DOI 10.1111/jphp.12218
   Benigni F, 2000, J CLIN INVEST, V106, P1291, DOI 10.1172/JCI9900
   Borg ML, 2011, DIABETES, V60, P1458, DOI 10.2337/db10-0845
   Brand KA, 1997, FASEB J, V11, P388, DOI 10.1096/fasebj.11.5.9141507
   Carnagarin R, 2016, MOL CELL ENDOCRINOL, V422, P115, DOI 10.1016/j.mce.2015.12.010
   Carnagarin R, 2015, MOL CELL ENDOCRINOL, V401, P98, DOI 10.1016/j.mce.2014.11.006
   Chandel NS, 1998, P NATL ACAD SCI USA, V95, P11715, DOI 10.1073/pnas.95.20.11715
   Chen C, 2010, J CLIN ENDOCR METAB, V95, P5074, DOI 10.1210/jc.2010-0727
   Chung C, 2008, J HEPATOL, V48, P471, DOI 10.1016/j.jhep.2007.10.012
   Colston JT, 2005, FEBS LETT, V579, P2533, DOI 10.1016/j.febslet.2005.03.057
   Crowe S, 2009, CELL METAB, V10, P40, DOI 10.1016/j.cmet.2009.06.001
   Dawson DW, 1999, SCIENCE, V285, P245, DOI 10.1126/science.285.5425.245
   Der-Torossian H, 2013, J CACHEXIA SARCOPENI, V4, P145, DOI 10.1007/s13539-012-0101-7
   Di Meo S, 2001, BIOL SIGNAL RECEPT, V10, P125
   Famulla S, 2011, INT J OBESITY, V35, P762, DOI 10.1038/ijo.2010.212
   Filleur S, 2005, CANCER RES, V65, P5144, DOI 10.1158/0008-5472.CAN-04-3744
   Foresti R, 2015, PHARMACOL RES, V99, P296, DOI 10.1016/j.phrs.2015.07.006
   Grönke S, 2005, CELL METAB, V1, P323, DOI 10.1016/j.cmet.2005.04.003
   Haemmerle G, 2006, SCIENCE, V312, P734, DOI 10.1126/science.1123965
   Herrero A, 1997, J BIOENERG BIOMEMBR, V29, P241, DOI 10.1023/A:1022458010266
   Jackson MJ, 2007, J APPL PHYSIOL, V102, P1664, DOI 10.1152/japplphysiol.01102.2006
   Jenkins CM, 2004, J BIOL CHEM, V279, P48968, DOI 10.1074/jbc.M407841200
   Kampfer C, 2014, LIFE SCI, V97, P129, DOI 10.1016/j.lfs.2013.12.007
   Kozlov AV, 2005, BBA-MOL BASIS DIS, V1740, P382, DOI 10.1016/j.bbadis.2004.11.004
   Li JM, 2002, CIRC RES, V90, P143, DOI 10.1161/hh0202.103615
   Li W, 2007, EXP NEUROL, V203, P457, DOI 10.1016/j.expneurol.2006.08.028
   Matono R, 2014, J BIOL CHEM, V289, P24874, DOI 10.1074/jbc.M114.581785
   Nakamura K, 2010, INT J CARDIOL, V143, P96, DOI 10.1016/j.ijcard.2008.11.169
   Nakamura K, 2009, DIABETES-METAB RES, V25, P52, DOI 10.1002/dmrr.820
   Nicholls David G, 2010, J Vis Exp, DOI 10.3791/2511
   Notari L, 2006, J BIOL CHEM, V281, P38022, DOI 10.1074/jbc.M600353200
   Petersen SV, 2003, BIOCHEM J, V374, P199, DOI 10.1042/BJ20030313
   Piao YJ, 2005, FREE RADICAL BIO MED, V38, P989, DOI 10.1016/j.freeradbiomed.2004.11.011
   Powers SK, 2008, PHYSIOL REV, V88, P1243, DOI 10.1152/physrev.00031.2007
   Remels AHV, 2015, ENDOCRINOLOGY, V156, P1770, DOI 10.1210/en.2014-1591
   Rychli K, 2009, EXPERT OPIN THER TAR, V13, P1295, DOI 10.1517/14728220903241641
   Sabater M, 2010, J CLIN ENDOCR METAB, V95, P4720, DOI 10.1210/jc.2010-0630
   Shi S.Y., 2015, NAT COMMUN, V6
   Smirnova E, 2006, EMBO REP, V7, P106, DOI 10.1038/sj.embor.7400559
   Spitzer J J, 1989, Prog Clin Biol Res, V286, P145
   Subramanian P, 2010, ADV EXP MED BIOL, V664, P29, DOI 10.1007/978-1-4419-1399-9_4
   Villena JA, 2004, J BIOL CHEM, V279, P47066, DOI 10.1074/jbc.M403855200
   Yamagishi SI, 2010, CURR MED CHEM, V17, P1995, DOI 10.2174/092986710791233670
   Yamagishi S, 2006, J CLIN ENDOCR METAB, V91, P2447, DOI 10.1210/jc.2005-2654
   Yang SM, 2011, J CLIN ENDOCR METAB, V96, P831, DOI 10.1210/jc.2010-2140
   Zhao XX, 2002, J BIOL CHEM, V277, P25385, DOI 10.1074/jbc.M203630200
   Zimmermann R, 2004, SCIENCE, V306, P1383, DOI 10.1126/science.1100747
NR 47
TC 13
Z9 13
U1 1
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1357-2725
EI 1878-5875
J9 INT J BIOCHEM CELL B
JI Int. J. Biochem. Cell Biol.
PD SEP
PY 2016
VL 78
BP 229
EP 236
DI 10.1016/j.biocel.2016.06.013
PG 8
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA DV9YE
UT WOS:000383297300024
PM 27343430
DA 2025-06-11
ER

PT J
AU Esmaealzadeh, D
   Ghalibaf, AM
   Rad, MS
   Rezaee, R
   Razavi, BM
   Hosseinzadeh, H
AF Esmaealzadeh, Danial
   Ghalibaf, AmirAli Moodi
   Rad, Mohammad Shariati
   Rezaee, Ramin
   Razavi, Bibi Marjan
   Hosseinzadeh, Hossein
TI Pharmacological effects of Safranal: An updated review
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Review
DE Crocus sativus Patent Review Saffron Safranal
ID SAFFRON CROCUS-SATIVUS; IN-VITRO ASSAYS; OXIDATIVE STRESS; AERIAL PARTS;
   VOLATILE CONSTITUENTS; ACTIVE CONSTITUENT; CANCER-THERAPY;
   BLOOD-PRESSURE; POTENTIAL USE; SERUM-LEVELS
AB Safranal (a monoterpene aldehyde) is the major volatile component of saffron which is responsible for the saffron unique odor. Several studies have shown the pharmacological activities of safranal including anti-oxidant, anti-inflammatory, cardioprotective, neuroprotective, nephroprotective, gastrointestinal protective, etc. This study was designed to review the pharmacological and medical effects of safranal and up-to-date previous knowledge. Moreover, some patents related to the pharmacological effects of safranal were gathered. Therefore, electronic databases including Web of Sciences, Scopus, and Pubmed for pharmacological effects and US patent, Patentscope, and Google Patent for patents were comprehensively searched by related English keywords from 2010 to June 2022. According to our review, most of the studies are related to the safranal effects on CNS such as antianxiety, analgesic, anticonvulsant, antiischemic, anti-tremor, memory enhancement and its protective effects on neurodegenerative disorders such as Alzheimer's, Parkinson and Huntington diseases. Other effects of safranal are antiasthmatic, antihypertensive, antiaging, anticataract, etc. Moreover, the protective effects of this agent on metabolic syndrome and diabetic nephropathy have been shown. Different mechanisms including anti-oxidant, anti-inflammatory, muscle relaxation, antiapoptotic, and regulatory effects on the genes and proteins expression related to signaling pathways of oxidative stress, inflammation, apoptosis, proliferation, etc. are involved in safranal pharmacological effects. Some patents for the prevention and/or treatment of different diseases such as liver cancer, sleep disorder, depression, cognitive disorder, obesity and PMS were also included. Based on the documents, safranal is considered a promising therapeutic agent although more clinical studies are needed to verify the beneficial effects of safranal in humans.
C1 [Esmaealzadeh, Danial; Rad, Mohammad Shariati] Mashhad Univ Med Sci, Sch Med, Mashhad, Iran.
   [Ghalibaf, AmirAli Moodi] Birjand Univ Med Sci, Student Res Comm, Fac Med, Birjand, Iran.
   [Rezaee, Ramin] Mashhad Univ Med Sci, Fac Med, Int UNESCO Ctr Hlth Related Basic Sci & Human Nutr, Mashhad, Iran.
   [Rezaee, Ramin] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
   [Razavi, Bibi Marjan] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Targeted Drug Delivery Res Ctr, Mashhad, Iran.
   [Razavi, Bibi Marjan; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Iran.
   [Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Birjand University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences
RP Razavi, BM (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Targeted Drug Delivery Res Ctr, Mashhad, Iran.; Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran.
EM razavimr@mums.ac.ir; hosseinzadehh@mums.ac.ir
RI Razavi, Bibi/AAY-5636-2020; Rezaee, Ramin/T-7810-2017; Hosseinzadeh,
   Hossein/F-3013-2010; Moodi Ghalibaf, AmirAli/AAX-1722-2021
FU Pharmaceutical Research Center at Mashhad University of Medical
   Sciences, Iran
FX This work was supported by the Pharmaceutical Research Center and the
   Vice Chancellor of Research, at Mashhad University of Medical Sciences,
   Iran.
CR Abdullaev FI, 2004, CANCER DETECT PREV, V28, P426, DOI 10.1016/j.cdp.2004.09.002
   Abdullaev FI, 2003, TOXICOL IN VITRO, V17, P731, DOI 10.1016/S0887-2333(03)00098-5
   Alavi MS, 2019, DRUG RES, V69, P323, DOI 10.1055/a-0790-8200
   Alayunt ON, 2019, AN ACAD BRAS CIENC, V91, DOI 10.1590/0001-3765201920181235
   Alinejad B, 2013, AVICENNA J PHYTOMEDI, V3, P321
   Amin A, 2019, United states patent, Patent No. [US202002776133A1, 202002776133]
   Amin A, 2019, Australia patent, Patent No. [AU2019264659A1, 2019264659]
   Amin A, 2019, United states patent, Patent No. [US20200253890A1, 20200253890]
   Amin B, 2015, IRAN J BASIC MED SCI, V18, P449
   Arihan O., 2016, E J MED, V21, P173
   Baluchnejadmojarad T, 2019, METAB BRAIN DIS, V34, P1747, DOI 10.1007/s11011-019-00481-6
   Boskabady MH, 2014, PHARMACOL REP, V66, P56, DOI 10.1016/j.pharep.2013.08.004
   Boskabady MH, 2011, FITOTERAPIA, V82, P162, DOI 10.1016/j.fitote.2010.08.017
   Bourges C, 2010, United states patent, Patent No. [US20100028464, 20100028464]
   Bukhari SI, 2015, PHYTOTHER RES, V29, P617, DOI 10.1002/ptr.5315
   Cheriyamundath S, 2018, PHYTOTHER RES, V32, P170, DOI 10.1002/ptr.5938
   Delkhosh-Kasmaie F, 2018, BIOMED PHARMACOTHER, V107, P203, DOI 10.1016/j.biopha.2018.07.165
   Düz M, 2020, J HELL VET MED SOC, V71, P1997, DOI 10.12681/jhvms.22942
   Erfanparast A, 2015, AVICENNA J PHYTOMEDI, V5, P392
   Farahmand SK, 2013, BIOGERONTOLOGY, V14, P63, DOI 10.1007/s10522-012-9409-0
   Farshid AA, 2015, AVICENNA J PHYTOMEDI, V5, P469
   Fatehi M, 2003, J ETHNOPHARMACOL, V84, P199, DOI 10.1016/S0378-8741(02)00299-4
   Fernández-Sánchez L, 2015, MOLECULES, V20, P13875, DOI 10.3390/molecules200813875
   Fernández-Sánchez L, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043074
   Feyzi R, 2016, IRAN J IMMUNOL, V13, P263, DOI IJIv13i4A3
   Formisano C, 2008, NAT PROD RES, V22, P840, DOI 10.1080/14786410701567747
   Formisano C, 2008, NAT PROD RES, V22, P833, DOI 10.1080/14786410701218259
   Forouzanfar F, 2021, N-S ARCH PHARMACOL, V394, P707, DOI 10.1007/s00210-020-01999-8
   Fotoohi A, 2021, NEUROCHEM RES, V46, P1372, DOI 10.1007/s11064-021-03271-8
   Frin E, 2020, WIPO (PCT) patent, Patent No. [WO2020229412A1, 2020229412]
   Garavand F, 2019, TRENDS FOOD SCI TECH, V89, P26, DOI 10.1016/j.tifs.2019.05.005
   Gaudout D, 2021, WIPO (PCT) patent, Patent No. [WO2021209455A1, 2021209455]
   Geromichalos GD, 2014, FOOD CHEM TOXICOL, V74, P45, DOI 10.1016/j.fct.2014.09.001
   Gholamnezhad Z, 2013, IRAN J BASIC MED SCI, V16, P1022
   Golmohammadzadeh S, 2011, IRAN J BASIC MED SCI, V14, P521
   Gupta M, 2021, TOXICOL APPL PHARM, V423, DOI 10.1016/j.taap.2021.115582
   Hadizadeh F, 2007, ACTA HORTIC, P405, DOI 10.17660/ActaHortic.2007.739.53
   Hazman Ö, 2015, INFLAMMATION, V38, P1537, DOI 10.1007/s10753-015-0128-y
   Hazman Ö, 2015, INFLAMMATION, V38, P1012, DOI 10.1007/s10753-014-0065-1
   Hemshekhar M, 2012, BIOCHIMIE, V94, P2723, DOI 10.1016/j.biochi.2012.08.013
   Heydari S., 2014, CAN CHEM T, V2, P221, DOI [10.13179/canchemtrans.2014.02.02.0097, DOI 10.13179/CANCHEMTRANS.2014.02.02.0097]
   Hosseinzadeh H, 2006, FITOTERAPIA, V77, P446, DOI 10.1016/j.fitote.2006.04.012
   Hosseinzadeh H, 2013, IRAN J PHARM RES, V12, P93
   Imenshahidi M, 2015, IRAN J PHARM RES, V14, P585
   Jalali-Heravi M, 2009, J CHROMATOGR A, V1216, P6088, DOI 10.1016/j.chroma.2009.06.067
   Joloudar TN, 2017, J IRAN CHEM SOC, V14, P2407, DOI 10.1007/s13738-017-1175-0
   Journal TSW, 2020, Sci World J, V2020
   Karafakioglu YS, 2017, BIOCHEM J, V474, P1195, DOI 10.1042/BCJ20160971
   Kareem VS, 2021, Iraqi J Pharm Sci., V30, P208
   Khameneh B, 2015, IRAN J BASIC MED SCI, V18, P58
   Khayyat S, 2016, United states patent, Patent No. [US9707203B1, 9707203]
   Khayyat S, 2018, SAUDI PHARM J, V26, P115, DOI 10.1016/j.jsps.2017.10.004
   Khorasany AR, 2016, IRAN J BASIC MED SCI, V19, P455
   Koul A, 2018, HUM EXP TOXICOL, V37, P13, DOI 10.1177/0960327116689715
   Kumud M, 2018, BIOORG CHEM, V77, P159, DOI 10.1016/j.bioorg.2017.12.030
   Lertnimitphun P, 2021, FRONT IMMUNOL, V12, DOI 10.3389/fimmu.2021.585595
   Lertnimitphun P, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.01281
   Liu BQ, 2018, PHARMAZIE, V73, P207, DOI 10.1691/ph.2018.7310
   Liu MS, 2017, INT J BIOL MACROMOL, V95, P145, DOI 10.1016/j.ijbiomac.2016.11.038
   Maggi L, 2011, FOOD CHEM, V128, P543, DOI 10.1016/j.foodchem.2011.03.063
   Mahdi FA., 2021, IRAQI J PHARMACEUT S, V30, P196
   Malekzadeh S, 2019, IRAN J BASIC MED SCI, V22, P1476, DOI [10.22038/IJBMS.2019.13992, 10.22038/ijbms.2019.13992]
   Melnyk J. P., 2010, Food Research International, V43, P1981, DOI 10.1016/j.foodres.2010.07.033
   Mirshafa SA, 2013, IRAN J PHARM RES, V12, P529
   Moallem SA, 2016, TOXICOL IND HEALTH, V32, P285, DOI 10.1177/0748233713500818
   Mollazadeh H, 2015, IRAN J BASIC MED SCI, V18, P1153
   Morra S, 2018, WIPO (PCT) patent., Patent No. [WO2018108879A1, 2018108879]
   Mzabri I, 2019, COSMETICS-BASEL, V6, DOI 10.3390/cosmetics6040063
   Naghshineh A, 2015, CHEM-BIOL INTERACT, V238, P151, DOI 10.1016/j.cbi.2015.06.023
   Nam KN, 2010, EUR J PHARMACOL, V648, P110, DOI 10.1016/j.ejphar.2010.09.003
   Nanda S, 2019, India patent., Patent No. [IN201911007661, 201911007661]
   Nassiri-Asl M., 2020, Oxidative Stress and Dietary Antioxidants in Neurological Diseases, P359
   Nassiri-Asl M, 2015, BIOACTIVE NUTRACEUTICALS AND DIETARY SUPPLEMENTS IN NEUROLOGICAL AND BRAIN DISEASE: PREVENTION AND THERAPY, P29, DOI 10.1016/B978-0-12-411462-3.00003-5
   Nelson DR, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11061125
   Nemati H, 2008, PHYTOMEDICINE, V15, P1038, DOI 10.1016/j.phymed.2008.07.008
   Noughabi MT, 2018, Indian J Forensic Med Toxicol, V12, P335
   Ozkececi ZT, 2016, BIOMED PHARMACOTHER, V83, P160, DOI 10.1016/j.biopha.2016.06.027
   Pan PK, 2016, CELL MOL BIOL, V62, P11, DOI [10.14715/cmb/2016.62.14.2, 10.14715/cmb/ 2016.62.14.2]
   Patel S, 2017, CRIT REV ONCOL HEMAT, V115, P27, DOI 10.1016/j.critrevonc.2017.04.010
   Patil PJ, 2016, Indian Drugs, V53, P62
   Pereira J, 2011, TALANTA, V83, P899, DOI 10.1016/j.talanta.2010.10.064
   Qin-Xiao, 2021, INT J OPHTHALMOL-CHI, V14, P981, DOI 10.18240/ijo.2021.07.04
   Radulovic N, 2009, CENT EUR J BIOL, V4, P404, DOI 10.2478/s11535-009-0026-0
   Rafieipour F, 2019, METAB BRAIN DIS, V34, P165, DOI 10.1007/s11011-018-0329-9
   Rattan SIS, 2008, AGEING RES REV, V7, P63, DOI 10.1016/j.arr.2007.03.002
   Rattan SIS, 2012, EXPERT OPIN DRUG DIS, V7, P439, DOI 10.1517/17460441.2012.677430
   Raymond J-M, 2017, European Patent Office patent, Patent No. [EP3446678A1, 3446678]
   Razavi BM, 2016, J PHARMACOPUNCT, V19, P329, DOI 10.3831/KPI.2016.19.034
   Razavi BM, 2021, NEUROSCIENCE DEPRESS, P493
   Rezaee R, 2013, IRAN J BASIC MED SCI, V16, P12
   Riahi-Zanjani B, 2015, AVICENNA J PHYTOMEDI, V5, P441
   Rios JL, 1996, PHYTOTHER RES, V10, P189, DOI 10.1002/(SICI)1099-1573(199605)10:3<189::AID-PTR754>3.0.CO;2-C
   Rondot C, 2020, WIPO (PCT) patent., Patent No. [WO2022128915A1, 2022128915]
   Sadeghnia HR, 2017, FOLIA NEUROPATHOL, V55, P206, DOI 10.5114/fn.2017.70485
   Sadeghnia HR, 2013, IRAN J BASIC MED SCI, V16, P73
   Sadiq AT, 2021, Int J Drug Deliv Technol, V11, P771
   Samarghandian S, 2015, EXP ANIM TOKYO, V64, P65, DOI 10.1538/expanim.14-0027
   Samarghandian S, 2014, PHARMACOGN MAG, V10, P419, DOI 10.4103/0973-1296.133296
   Samarghandian S, 2014, SCI WORLD J, DOI 10.1155/2014/251378
   Samarghandian Saeed, 2013, Indian J Urol, V29, P177, DOI 10.4103/0970-1591.117278
   Samarghandian S, 2013, J PHARM PHARM SCI, V16, P352, DOI 10.18433/J3ZS3Q
   Samarghandian S, 2010, PHARMACOGN MAG, V6, P309, DOI 10.4103/0973-1296.71799
   Samini M., 2017, ANN RES REV BIOL, V15, P1, DOI [10.9734/ARRB/2017/35478, DOI 10.9734/ARRB/2017/35478]
   Sánchez AM, 2011, J AGR FOOD CHEM, V59, P249, DOI 10.1021/jf102828v
   Sanju N, 2022, J COSMET DERMATOL-US, V21, P4433, DOI 10.1111/jocd.14777
   Save SS, 2019, INT J BIOL MACROMOL, V141, P585, DOI 10.1016/j.ijbiomac.2019.09.053
   Shahat AS, 2022, NUTR NEUROSCI, V25, P231, DOI 10.1080/1028415X.2020.1743917
   Shahi T, 2016, TRENDS FOOD SCI TECH, V58, P69, DOI 10.1016/j.tifs.2016.10.010
   Shokrpour M, 2019, ADVANCES IN PLANT BREEDING STRATEGIES: INDUSTRIAL AND FOOD CROPS, VOL 6, P675, DOI 10.1007/978-3-030-23265-8_17
   Taddei A, 2020, United states patent, Patent No. [US20220218779A1, 20220218779]
   Tamaddonfard E, 2019, LIFE SCI, V224, P88, DOI 10.1016/j.lfs.2019.03.054
   Tamaddonfard E, 2014, PHYTOMEDICINE, V21, P717, DOI 10.1016/j.phymed.2013.10.031
   Tamaddonfard E, 2013, PHARMACOL REP, V65, P1272, DOI 10.1016/S1734-1140(13)71485-3
   Tamaddonfard E, 2010, PHYTOTHER RES, V24, P410, DOI 10.1002/ptr.2965
   Thomaoglou C, 2015, France patent, Patent No. [WO2015124318, 2015124318]
   Wang HF, 2021, EXP THER MED, V22, DOI 10.3892/etm.2021.10836
   Xu GL, 2009, J AGR FOOD CHEM, V57, P8325, DOI 10.1021/jf901752f
   Xue YR, 2020, J PHARMACOL SCI, V143, P156, DOI 10.1016/j.jphs.2020.03.005
   Zhang C, 2015, TISSUE CELL, V47, P291, DOI 10.1016/j.tice.2015.03.007
   Zhang SP, 2017, BIOMED RES-INDIA, V28, P817
   Zhang YB, 2018, J BUON, V23, P574
   Zhao Y, 2018, PHARM BIOL, V56, P450, DOI 10.1080/13880209.2018.1501705
   Zhu KJ, 2014, INT J CLIN EXP MED, V7, P4990
   Ziaee T, 2014, JUNDISHAPUR J NAT PH, V9, P3
NR 124
TC 18
Z9 18
U1 7
U2 14
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD OCT
PY 2023
VL 26
IS 10
BP 1131
EP 1143
DI 10.22038/IJBMS.2023.69824.15197
PG 13
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA CH0I5
UT WOS:001124240800010
PM 37736506
DA 2025-06-11
ER

PT J
AU Fang, CL
   Liu, B
   Wan, M
AF Fang, Ching-Lien
   Liu, Bin
   Wan, Mei
TI "Bone-SASP" in Skeletal Aging
SO CALCIFIED TISSUE INTERNATIONAL
LA English
DT Review
DE Bone-SASP; Cellular senescence; Osteoarthritis; Osteoporosis; Premature
   aging syndromes; Progeria syndrome; Senescence-associated secretory
   phenotype (SASP); Skeletal aging
ID MESENCHYMAL STEM-CELLS; TELOMERIC DNA-DAMAGE; NF-KAPPA-B; CELLULAR
   SENESCENCE; SECRETORY PHENOTYPE; POSTTRAUMATIC OSTEOARTHRITIS;
   OSTEOGENIC DIFFERENTIATION; METABOLIC SYNDROME; INDUCED EXPRESSION;
   OXIDATIVE STRESS
AB Senescence is a complex cell state characterized by stable cell cycle arrest and a unique secretory pattern known as the senescence-associated secretory phenotype (SASP). The SASP factors, which are heterogeneous and tissue specific, normally include chemokines, cytokines, growth factors, adhesion molecules, and lipid components that can lead to multiple age-associated disorders by eliciting local and systemic consequences. The skeleton is a highly dynamic organ that changes constantly in shape and composition. Senescent cells in bone and bone marrow produce diverse SASP factors that induce alterations of the skeleton through paracrine effects. Herein, we refer to bone cell-associated SASP as "bone-SASP." In this review, we describe current knowledge of cellular senescence and SASP, focusing on the role of senescent cells in mediating bone pathologies during natural aging and premature aging syndromes. We also summarize the role of cellular senescence and the bone-SASP in glucocorticoids-induced bone damage. In addition, we discuss the role of bone-SASP in the development of osteoarthritis, highlighting the mechanisms by which bone-SASP drives subchondral bone changes in metabolic syndrome-associated osteoarthritis.
C1 [Fang, Ching-Lien; Liu, Bin; Wan, Mei] Johns Hopkins Univ, Sch Med, Dept Orthopaed Surg, Baltimore, MD 21205 USA.
   [Wan, Mei] Johns Hopkins Univ, Sch Med, Dept Orthopaed Surg, Ross Bldg,Room 209,720 Rutland Ave, Baltimore, MD 21205 USA.
C3 Johns Hopkins University; Johns Hopkins University
RP Wan, M (corresponding author), Johns Hopkins Univ, Sch Med, Dept Orthopaed Surg, Baltimore, MD 21205 USA.; Wan, M (corresponding author), Johns Hopkins Univ, Sch Med, Dept Orthopaed Surg, Ross Bldg,Room 209,720 Rutland Ave, Baltimore, MD 21205 USA.
EM mwan4@jhmi.edu
FU National Institutes of Health [R01AG068226, R01AG072090, P01AG066603]
FX AcknowledgementsThe authors acknowledge the assistance of Rachel Box,
   MS, at The Johns Hopkins Department of Orthopedic Surgery Editorial
   Services for editing the manuscript. This work was supported by the
   National Institutes of Health grant R01AG068226 and R01AG072090 to M.W.
   and P01AG066603 to X.C.
CR Acosta JC, 2008, CELL, V133, P1006, DOI 10.1016/j.cell.2008.03.038
   Adhikary S, 2018, NUTRITION, V53, P64, DOI 10.1016/j.nut.2017.12.003
   Alfonzo MC, 2022, JBMR PLUS, V6, DOI 10.1002/jbm4.10686
   ALLSOPP RC, 1995, EXP CELL RES, V220, P194, DOI 10.1006/excr.1995.1306
   Amarasekara DS, 2018, IMMUNE NETW, V18, DOI 10.4110/in.2018.18.e8
   Ambrosi TH, 2021, NATURE, V597, P256, DOI 10.1038/s41586-021-03795-7
   Astrike-Davis EM, 2022, CURR OPIN PHARMACOL, V64, DOI 10.1016/j.coph.2022.102213
   Baar MP, 2017, CELL, V169, P132, DOI 10.1016/j.cell.2017.02.031
   Bailey AJ, 1997, GERONTOLOGY, V43, P296
   Baker DJ, 2011, NATURE, V479, P232, DOI 10.1038/nature10600
   Barnhoorn S, 2014, PLOS GENET, V10, DOI 10.1371/journal.pgen.1004686
   Basisty N, 2020, PLOS BIOL, V18, DOI 10.1371/journal.pbio.3000599
   Bavik C, 2006, CANCER RES, V66, P794, DOI 10.1158/0008-5472.CAN-05-1716
   Bergo MO, 2002, P NATL ACAD SCI USA, V99, P13049, DOI 10.1073/pnas.192460799
   Bodnar AG, 1998, SCIENCE, V279, P349, DOI 10.1126/science.279.5349.349
   Bringold F, 2000, EXP GERONTOL, V35, P317, DOI 10.1016/S0531-5565(00)00083-8
   BROESTL L, 2021, ENDOCRINOLOGY, V162, DOI DOI 10.1210/endocr/bqab192
   Brown TD, 2006, J ORTHOP TRAUMA, V20, P739, DOI 10.1097/01.bot.0000246468.80635.ef
   Butin-Israeli V, 2012, TRENDS GENET, V28, P464, DOI 10.1016/j.tig.2012.06.001
   Calcinotto A, 2019, PHYSIOL REV, V99, P1047, DOI 10.1152/physrev.00020.2018
   Campos A, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21020446
   Chadha R, 2016, J ORTHOP, V13, P347, DOI 10.1016/j.jor.2016.06.029
   Chaib S, 2022, HANDB EXP PHARMACOL, V274, P165, DOI 10.1007/164_2021_555
   Chandra A, 2022, AGING CELL, V21, DOI 10.1111/acel.13602
   Chang AC, 2018, CANCER LETT, V426, P47, DOI 10.1016/j.canlet.2018.03.050
   Chang JH, 2016, NAT MED, V22, P78, DOI 10.1038/nm.4010
   Chapman J, 2019, FEBS LETT, V593, P1566, DOI 10.1002/1873-3468.13498
   Chen MH, 2021, FRONT CELL DEV BIOL, V9, DOI 10.3389/fcell.2021.650250
   Chen Q, 2013, J BONE MINER RES, V28, P1214, DOI 10.1002/jbmr.1851
   Cherry C, 2023, GEROSCIENCE, V45, P2559, DOI 10.1007/s11357-023-00785-7
   Cheung CYL, 2014, ALZHEIMERS DEMENT, V10, P135, DOI 10.1016/j.jalz.2013.06.009
   Chien MH, 2009, CARCINOGENESIS, V30, P2005, DOI 10.1093/carcin/bgp244
   Chiou WF, 2011, LIFE SCI, V88, P335, DOI 10.1016/j.lfs.2010.12.009
   Cho Y, 2021, EXP MOL MED, V53, P1689, DOI 10.1038/s12276-021-00710-y
   Coppé JP, 2010, ANNU REV PATHOL-MECH, V5, P99, DOI 10.1146/annurev-pathol-121808-102144
   Coppé JP, 2008, PLOS BIOL, V6, P2853, DOI 10.1371/journal.pbio.0060301
   Courties A, 2017, CURR OPIN RHEUMATOL, V29, P214, DOI 10.1097/BOR.0000000000000373
   Criscione SW, 2016, TRENDS GENET, V32, P751, DOI 10.1016/j.tig.2016.09.005
   Cui Z, 2016, ANN RHEUM DIS, V75, P1714, DOI 10.1136/annrheumdis-2015-207923
   Davalos AR, 2013, J CELL BIOL, V201, P613, DOI 10.1083/jcb.201206006
   Davies BSJ, 2009, ANNU REV GENOM HUM G, V10, P153, DOI 10.1146/annurev-genom-082908-150150
   De Cecco M, 2019, NATURE, V572, pE5, DOI [10.1038/s41586-019-1350-9, 10.1038/s41586-018-0784-9]
   de Lange T, 2005, GENE DEV, V19, P2100, DOI 10.1101/gad.1346005
   De Sandre-Giovannoli A, 2003, SCIENCE, V300, P2055, DOI 10.1126/science.1084125
   Demaria M, 2014, DEV CELL, V31, P722, DOI 10.1016/j.devcel.2014.11.012
   di Fagagna FD, 2008, NAT REV CANCER, V8, P512, DOI 10.1038/nrc2440
   DI LEONARDO A, 1994, GENE DEV, V8, P2540, DOI 10.1101/gad.8.21.2540
   Dollé MET, 2011, PATHOBIOL AGING AGE, V1, DOI 10.3402/pba.v1i0.7219
   Doolittle ML, 2021, MECH AGEING DEV, V199, DOI 10.1016/j.mad.2021.111565
   Du XB, 2004, MOL CELL BIOL, V24, P8437, DOI 10.1128/MCB.24.19.8437-8446.2004
   Englesbe MJ, 2004, J VASC SURG, V39, P1091, DOI 10.1016/j.jvs.2004.01.041
   EPSTEIN CJ, 1966, MEDICINE, V45, P177, DOI 10.1097/00005792-196605000-00001
   Eriksson M, 2003, NATURE, V423, P293, DOI 10.1038/nature01629
   Fang H, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-21184-5
   Farnaghi S, 2017, INT J RHEUM DIS, V20, P131, DOI 10.1111/1756-185X.13061
   Farr JN, 2017, NAT MED, V23, P1072, DOI 10.1038/nm.4385
   Farr JN, 2016, J BONE MINER RES, V31, P1920, DOI 10.1002/jbmr.2892
   Farr JN, 2015, NAT REV ENDOCRINOL, V11, P513, DOI 10.1038/nrendo.2015.89
   Faust HJ, 2020, J CLIN INVEST, V130, P5493, DOI 10.1172/JCI134091
   Freund A, 2010, TRENDS MOL MED, V16, P238, DOI 10.1016/j.molmed.2010.03.003
   Fuhrmann-Stroissnigg H, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-00314-z
   Fumagalli M, 2012, NAT CELL BIOL, V14, P355, DOI 10.1038/ncb2466
   Gargiuli Chiara, 2018, Oncotarget, V9, P22817, DOI 10.18632/oncotarget.25071
   Gasek NS, 2021, NATURE AGING, V1, P870, DOI 10.1038/s43587-021-00121-8
   Gerace L, 2012, J STRUCT BIOL, V177, P24, DOI 10.1016/j.jsb.2011.11.007
   Giacinti C, 2006, ONCOGENE, V25, P5220, DOI 10.1038/sj.onc.1209615
   Glyn-Jones S, 2015, LANCET, V386, P376, DOI 10.1016/S0140-6736(14)60802-3
   Gorgoulis V, 2019, CELL, V179, P813, DOI 10.1016/j.cell.2019.10.005
   Goto T, 2015, CYTOTECHNOLOGY, V67, P357, DOI 10.1007/s10616-014-9694-3
   Griveau A, 2020, AGING CELL, V19, DOI 10.1111/acel.13122
   Gruenbaum Y, 2015, ANNU REV BIOCHEM, V84, P131, DOI 10.1146/annurev-biochem-060614-034115
   Gudmundsrud R, 2021, CYTOGENET GENOME RES, V161, P297, DOI 10.1159/000516386
   Hamar A, 2021, OSTEOPOROSIS INT, V32, P1621, DOI 10.1007/s00198-021-05871-0
   Hambright WS, 2019, BONE, V125, P122, DOI 10.1016/j.bone.2019.03.002
   Hamzic N, 2013, J NEUROENDOCRINOL, V25, P271, DOI 10.1111/jne.12000
   Hartmann K, 2016, PHYSIOL REV, V96, P409, DOI 10.1152/physrev.00011.2015
   HAYFLICK L, 1961, EXP CELL RES, V25, P585, DOI 10.1016/0014-4827(61)90192-6
   He YC, 2022, BIOLOGY-BASEL, V11, DOI 10.3390/biology11070996
   Hewitt G, 2012, NAT COMMUN, V3, DOI 10.1038/ncomms1708
   Hinze C, 2018, J CELL SCI, V131, DOI 10.1242/jcs.216804
   Hoare E, 2016, INT J BEHAV NUTR PHY, V13, DOI 10.1186/s12966-016-0432-4
   Houtkooper RH, 2010, ENDOCR REV, V31, P194, DOI 10.1210/er.2009-0026
   Hu XY, 2021, SIGNAL TRANSDUCT TAR, V6, DOI 10.1038/s41392-021-00791-1
   Hunter DJ, 2019, LANCET, V393, P1745, DOI 10.1016/S0140-6736(19)30417-9
   Infante A, 2014, AGING-US, V6, P264, DOI 10.18632/aging.100651
   Jain S, 2006, CANCER RES, V66, P6638, DOI 10.1158/0008-5472.CAN-06-0661
   Jakhar R, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20102547
   Jeon OH, 2019, JCI INSIGHT, V4, DOI 10.1172/jci.insight.125019
   Jeon OH, 2017, NAT MED, V23, P775, DOI 10.1038/nm.4324
   Jilka RL, 2013, J GERONTOL A-BIOL, V68, P1209, DOI 10.1093/gerona/glt046
   Kamal NSM, 2020, EUR J CELL BIOL, V99, DOI 10.1016/j.ejcb.2020.151108
   Kang HJ, 2011, NATURE, V478, P483, DOI 10.1038/nature10523
   Kim EC, 2019, BMB REP, V52, P47
   Kirkland JL, 2020, J INTERN MED, V288, P518, DOI 10.1111/joim.13141
   Kirkland JL, 2017, EBIOMEDICINE, V21, P21, DOI 10.1016/j.ebiom.2017.04.013
   Knutson MD, 2008, NUTR REV, V66, P591, DOI 10.1111/j.1753-4887.2008.00109.x
   Krishnamurthy Janakiraman, 2004, J Clin Invest, V114, P1299
   Kubben N, 2017, NAT REV MOL CELL BIO, V18, P595, DOI 10.1038/nrm.2017.68
   Kulkarni AS, 2020, CELL METAB, V32, P15, DOI 10.1016/j.cmet.2020.04.001
   Kumar R, 2019, BIOGERONTOLOGY, V20, P171, DOI 10.1007/s10522-018-9785-1
   Kurz DJ, 2004, J CELL SCI, V117, P2417, DOI 10.1242/jcs.01097
   Lanske B, 1996, SCIENCE, V273, P663, DOI 10.1126/science.273.5275.663
   Lee JY, 2018, EXP MOL MED, V50, DOI 10.1038/s12276-018-0092-3
   Lee SB, 2018, CHEM-BIOL INTERACT, V284, P101, DOI 10.1016/j.cbi.2018.02.022
   Lee WS, 2014, INFLAMMATION, V37, P1221, DOI 10.1007/s10753-014-9849-6
   Lei Q, 2017, THERANOSTICS, V7, P2673, DOI 10.7150/thno.18915
   Lengefeld J, 2021, SCI ADV, V7, DOI 10.1126/sciadv.abk0271
   Li CJ, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01509-0
   Li W, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019313
   Li YK, 2018, J EXP CLIN CANC RES, V37, DOI 10.1186/s13046-018-0839-7
   Lim H, 2015, BIOCHEM PHARMACOL, V96, P337, DOI 10.1016/j.bcp.2015.06.013
   Liu D, 2007, CANCER RES, V67, P3117, DOI 10.1158/0008-5472.CAN-06-3452
   Liu G, 2023, ADV SCI WEINH
   Liu JT, 2022, J CLIN INVEST, V132, DOI 10.1172/JCI148073
   Liu XA, 2023, CELL METAB, V35, P667, DOI 10.1016/j.cmet.2023.03.005
   Liu XN, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-22131-1
   Liu XN, 2019, INT REV CEL MOL BIO, V346, P97, DOI 10.1016/bs.ircmb.2019.03.005
   Liu YK, 2022, ARTHRITIS RES THER, V24, DOI 10.1186/s13075-022-02859-x
   Lories RJ, 2011, NAT REV RHEUMATOL, V7, P43, DOI 10.1038/nrrheum.2010.197
   Lu JS, 2018, J BONE MINER RES, V33, P909, DOI 10.1002/jbmr.3388
   Lujambio A, 2013, CELL, V153, P449, DOI 10.1016/j.cell.2013.03.020
   Madry H, 2010, KNEE SURG SPORT TR A, V18, P417, DOI 10.1007/s00167-010-1071-y
   Malaquin N, 2019, METHODS MOL BIOL, V1896, P45, DOI 10.1007/978-1-4939-8931-7_6
   Malorni W, 2008, METHOD ENZYMOL, V442, P125, DOI 10.1016/S0076-6879(08)01406-7
   Mansell JP, 2007, NAT CLIN PRACT RHEUM, V3, P306, DOI 10.1038/ncprheum0505
   Martínez-Cué C, 2020, FRONT CELL NEUROSCI, V14, DOI 10.3389/fncel.2020.00016
   McCarthy TL, 2000, CRIT REV ORAL BIOL M, V11, P409, DOI 10.1177/10454411000110040201
   MITSUI Y, 1976, MECH AGEING DEV, V5, P45, DOI 10.1016/0047-6374(76)90007-5
   MohazzabH KM, 1997, CIRCULATION, V96, P614
   Moncsek A, 2018, HEPATOLOGY, V67, P247, DOI 10.1002/hep.29464
   Mooi WJ, 2006, NEW ENGL J MED, V355, P1037, DOI 10.1056/NEJMra062285
   Mori S, 2021, GERIATR GERONTOL INT, V21, P146, DOI 10.1111/ggi.14078
   Moulson CL, 2005, J INVEST DERMATOL, V125, P913, DOI 10.1111/j.0022-202X.2005.23846.x
   Muñoz-Espín D, 2013, CELL, V155, P1104, DOI 10.1016/j.cell.2013.10.019
   Murphy MP, 2013, CELL METAB, V18, P145, DOI 10.1016/j.cmet.2013.07.006
   Myrianthopoulos V, 2018, FUTURE MED CHEM, V10, P2369, DOI 10.4155/fmc-2018-0234
   Navarro CL, 2014, EUR J HUM GENET, V22, DOI 10.1038/ejhg.2013.258
   Ng M, 2022, NEUROBIOL AGING, V120, P88, DOI 10.1016/j.neurobiolaging.2022.08.014
   Niedernhofer LJ, 2006, NATURE, V444, P1038, DOI 10.1038/nature05456
   Nowak B, 2017, PHARMACOL REP, V69, P1113, DOI 10.1016/j.pharep.2017.05.002
   Oo WM, 2022, THER ADV MUSCULOSKEL, V14, DOI 10.1177/1759720X221090297
   Osmanagic-Myers S, 2015, GENE DEV, V29, P225, DOI 10.1101/gad.255968.114
   Osorio FG, 2012, GENE DEV, V26, P2311, DOI 10.1101/gad.197954.112
   Pan FF, 2021, AM J PHYSIOL-ENDOC M, V320, pE760, DOI 10.1152/ajpendo.00543.2019
   Panagopoulos V, 2017, INT J ONCOL, V50, P1191, DOI 10.3892/ijo.2017.3883
   Pang JL, 2006, BIOCHEM PHARMACOL, V71, P818, DOI 10.1016/j.bcp.2005.12.023
   Passos JF, 2007, PLOS BIOL, V5, P1138, DOI 10.1371/journal.pbio.0050110
   Perrott KM, 2017, GEROSCIENCE, V39, P161, DOI 10.1007/s11357-017-9970-1
   Piemontese M, 2017, JCI INSIGHT, V2, DOI 10.1172/jci.insight.93771
   Pignolo RJ, 2008, AGING CELL, V7, P23, DOI 10.1111/j.1474-9726.2007.00350.x
   Prata Larissa G P Langhi, 2018, Semin Immunol, V40, P101275, DOI 10.1016/j.smim.2019.04.003
   Rall-Scharpf M, 2021, AGING-US, V13, P21066, DOI 10.18632/aging.203519
   Ren B, 2002, GENE DEV, V16, P245, DOI 10.1101/gad.949802
   Rieckher M, 2021, TRENDS MOL MED, V27, P907, DOI 10.1016/j.molmed.2021.06.011
   Rivas D, 2009, J GERONTOL A-BIOL, V64, P1015, DOI 10.1093/gerona/glp089
   Robles SJ, 1998, ONCOGENE, V16, P1113, DOI 10.1038/sj.onc.1201862
   Rodier F, 2009, NAT CELL BIOL, V11, P973, DOI 10.1038/ncb1909
   Rose-John S, 2018, CSH PERSPECT BIOL, V10, DOI 10.1101/cshperspect.a028415
   Rossiello F, 2014, CURR OPIN GENET DEV, V26, P89, DOI 10.1016/j.gde.2014.06.009
   Ruscitti P, 2015, MEDIAT INFLAMM, V2015, DOI 10.1155/2015/782382
   SALK J, 1981, DEV BIOL STAND, V47, P181
   Santhanam L, 2021, J CLIN INVEST, V131, DOI 10.1172/JCI147116
   Saul D, 2022, NAT COMMUN, V13, DOI 10.1038/s41467-022-32552-1
   Saul D, 2021, ELIFE, V10, DOI [10.7554/eLife.69958, 10.7554/eLife.69958.sa1, 10.7554/eLife.69958.sa2]
   Schafer MJ, 2020, JCI INSIGHT, V5, DOI 10.1172/jci.insight.133668
   Schwab N, 2022, FRONT NEUROSCI-SWITZ, V16, DOI 10.3389/fnins.2022.1027116
   Schwarzenbach C, 2021, CANCERS, V13, DOI 10.3390/cancers13143585
   Sengupta D, 2022, MUTAT RES-FUND MOL M, V825, DOI 10.1016/j.mrfmmm.2022.111788
   Sharpless NE, 2015, NAT REV CANCER, V15, P397, DOI 10.1038/nrc3960
   Squarzoni S, 2021, AGING CELL, V20, DOI 10.1111/acel.13285
   Srinivas N, 2020, CANCERS, V12, DOI 10.3390/cancers12030558
   Starling S, 2023, NAT REV ENDOCRINOL, V19, P312, DOI 10.1038/s41574-023-00843-2
   Stefanatos R, 2018, FEBS LETT, V592, P743, DOI 10.1002/1873-3468.12902
   Storer M, 2013, CELL, V155, P1119, DOI 10.1016/j.cell.2013.10.041
   Strandgren C, 2017, BIOCHEM SOC T, V45, P1279, DOI 10.1042/BST20170141
   Su WP, 2022, ELIFE, V11, DOI 10.7554/eLife.79773
   Su WP, 2020, JCI INSIGHT, V5, DOI 10.1172/jci.insight.135446
   Su YP, 2017, J CELL PHYSIOL, V232, P1448, DOI 10.1002/jcp.25644
   Sun Q, 2021, ELIFE, V10, DOI 10.7554/eLife.66532
   Sun Y, 2022, CELL BIOSCI, V12, DOI 10.1186/s13578-022-00815-5
   Tang FY, 2022, EVID-BASED COMPL ALT, V2022, DOI 10.1155/2022/6741995
   Terzi MY, 2016, MOL BIOL REP, V43, P1213, DOI 10.1007/s11033-016-4065-0
   Tian YY, 2022, NAT COMMUN, V13, DOI 10.1038/s41467-022-33012-6
   Tong LP, 2023, CELL METAB, V35, P551, DOI 10.1016/j.cmet.2023.03.009
   Trivedi R, 2008, MOL CELL ENDOCRINOL, V289, P85, DOI 10.1016/j.mce.2008.02.027
   Von Zglinicki T, 2000, ANN NY ACAD SCI, V908, P99, DOI 10.1111/j.1749-6632.2000.tb06639.x
   von Zglinicki T, 2005, MECH AGEING DEV, V126, P111, DOI 10.1016/j.mad.2004.09.034
   von Zglinicki T, 2003, NAT BIOTECHNOL, V21, P229, DOI 10.1038/nbt0303-229b
   Walsh DA, 2007, OSTEOARTHR CARTILAGE, V15, P743, DOI 10.1016/j.joca.2007.01.020
   Wan M, 2021, BONE RES, V9, DOI 10.1038/s41413-021-00164-y
   Wang AS, 2018, FRONT GENET, V9, DOI 10.3389/fgene.2018.00247
   Wang CF, 2009, AGING CELL, V8, P311, DOI 10.1111/j.1474-9726.2009.00481.x
   Wang YX, 2022, P NATL ACAD SCI USA, V119, DOI 10.1073/pnas.2118695119
   Ward LM, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00576
   Wiley CD, 2021, CELL METAB, V33, P1124, DOI 10.1016/j.cmet.2021.03.008
   Wiley CD, 2019, CELL REP, V28, P3329, DOI 10.1016/j.celrep.2019.08.049
   Wong A, 2020, AGING-US, V12, P24481, DOI 10.18632/aging.202321
   Wong SK, 2019, DRUG DES DEV THER, V13, P3497, DOI 10.2147/DDDT.S227738
   Xie L, 2016, ANN NY ACAD SCI, V1376, P53, DOI 10.1111/nyas.13000
   Xu M, 2016, PHARMACOL RES, V111, P152, DOI 10.1016/j.phrs.2016.05.015
   Xu M, 2015, P NATL ACAD SCI USA, V112, pE6301, DOI 10.1073/pnas.1515386112
   Xue W, 2007, NATURE, V445, P656, DOI 10.1038/nature05529
   Yang L, 2010, J CELL BIOCHEM, V110, P1342, DOI 10.1002/jcb.22649
   Yosef R, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms11190
   Young ARJ, 2009, EMBO REP, V10, P228, DOI 10.1038/embor.2009.22
   Young SG, 2006, J BIOL CHEM, V281, P39741, DOI 10.1074/jbc.R600033200
   Yousefzadeh MJ, 2018, EBIOMEDICINE, V36, P18, DOI 10.1016/j.ebiom.2018.09.015
   ZHANG L, 2021, AGING CELL, V20
   Zhang L, 2023, FEBS J, V290, P1362, DOI 10.1111/febs.16350
   Zhang YJ, 2021, FRONT GENET, V12, DOI 10.3389/fgene.2021.597566
   Zhao XL, 2021, J BONE MINER RES, V36, P591, DOI 10.1002/jbmr.4215
   Zhen GH, 2013, NAT MED, V19, P704, DOI 10.1038/nm.3143
   Zhou T, 2019, REDOX REP, V24, P62, DOI 10.1080/13510002.2019.1658376
   Zhou YY, 2021, NPJ REGEN MED, V6, DOI 10.1038/s41536-021-00145-z
   Zhu J, 2017, INT IMMUNOPHARMACOL, V43, P236, DOI 10.1016/j.intimp.2016.12.020
   Zhu SA, 2019, J CLIN INVEST, V129, P1076, DOI 10.1172/JCI121561
   Zhu XD, 2021, SIGNAL TRANSDUCT TAR, V6, DOI 10.1038/s41392-021-00646-9
   Zhu Y, 2016, AGING CELL, V15, P428, DOI 10.1111/acel.12445
   Zhu Y, 2015, AGING CELL, V14, P644, DOI 10.1111/acel.12344
   Zhuo Q, 2012, NAT REV RHEUMATOL, V8, P729, DOI 10.1038/nrrheum.2012.135
NR 220
TC 19
Z9 21
U1 9
U2 37
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0171-967X
EI 1432-0827
J9 CALCIFIED TISSUE INT
JI Calcif. Tissue Int.
PD JUL
PY 2023
VL 113
IS 1
SI SI
BP 68
EP 82
DI 10.1007/s00223-023-01100-4
EA MAY 2023
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA L1GX3
UT WOS:000998319700001
PM 37256358
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Bergmann, K
   Sypniewska, G
AF Bergmann, Katarzyna
   Sypniewska, Grazyna
TI Diabetes as a complication of adipose tissue dysfunction. Is there a
   role for potential new biomarkers?
SO CLINICAL CHEMISTRY AND LABORATORY MEDICINE
LA English
DT Review
DE adipokines; adipose tissue; diabetes type 2; inflammation; insulin
   resistance; obesity
ID ACID-BINDING PROTEIN; DIPEPTIDYL-PEPTIDASE 4; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; GENE-EXPRESSION; OBESITY;
   INFLAMMATION; ADIPOKINES; CHEMERIN
AB Increasing incidence of type 2 diabetes is a major health problem of the modern world and requires new diagnostic tools to assess early metabolic disorders, particularly insulin resistance. The link between obesity, inflammation and insulin resistance indicates the important secretory role of adipose tissue. Proinflammatory factors (cytokines, adipokines) produced by enlarged adipose tissue are related to impaired glucose metabolism. Adipokines act as paracrine factors in adipose tissue and as endocrine hormones in the liver, muscles and central nervous system. Novel adipokines secreted from adipocytes such as retinol binding protein-4 (RBP-4), vaspin, omentin, chemerin, fibroblast growth factor 21 (FGF21), adipocyte fatty acid-binding protein (A-FABP) and dipeptidyl peptidase 4 (DPP4) demonstrate pleiotropic activity and their insulin-sensitizing or enhancing insulin resistance properties have not been clearly confirmed yet. In spite of the lack of standardized automated assay methods currently available for these novel biomarkers, promising results from several studies emphasize that they might potentially be useful prognostic factors for diabetes and its complications, especially in individuals without the typical symptoms of metabolic syndrome.
C1 [Bergmann, Katarzyna; Sypniewska, Grazyna] Nicholas Copernicus Univ, Coll Med Bydgoszcz, Dept Lab Med, Bydgoszcz, Poland.
C3 Nicolaus Copernicus University
RP Bergmann, K (corresponding author), Nicholas Copernicus Univ, Coll Med Bydgoszcz, Dept Lab Med, Bydgoszcz, Poland.
EM bergmann@vp.pl
RI ODROWAZ-SYPNIEWSKA, GRAZYN/H-1088-2014; Bergmann, Katarzyna/D-4228-2014
OI Bergmann, Katarzyna/0000-0001-9912-0325
CR Abbasi A, 2010, J CLIN ENDOCR METAB, V95, pE26, DOI 10.1210/jc.2010-0305
   [Anonymous], 2009, ENDOKRYNOL OTYLOSC Z
   Antuna-Puente B, 2008, DIABETES METAB, V34, P2, DOI 10.1016/j.diabet.2007.09.004
   Arner P, 2008, FEBS LETT, V582, P1725, DOI 10.1016/j.febslet.2008.04.038
   Auguet T, 2011, BMC MED GENET, V12, DOI 10.1186/1471-2350-12-60
   Batista CMDS, 2007, DIABETES, V56, P1655, DOI 10.2337/db06-1506
   Billings LK, 2010, ANN NY ACAD SCI, V1212, P59, DOI 10.1111/j.1749-6632.2010.05838.x
   Blüher M, 2012, ENDOCRINE, V41, P176, DOI 10.1007/s12020-011-9572-0
   Bobbert T, 2012, DIABETES CARE
   Bozaoglu K, 2007, ENDOCRINOLOGY, V148, P4687, DOI 10.1210/en.2007-0175
   Cakal E, 2011, GYNECOL ENDOCRINOL, V27, P491, DOI 10.3109/09513590.2010.501874
   Chang YH, 2011, DIABETES-METAB RES, V27, P515, DOI 10.1002/dmrr.1201
   Chen XL, 2005, J PROTEOME RES, V4, P570, DOI 10.1021/pr049772a
   Choi KM, 2011, AM J CLIN NUTR, V93, P19, DOI 10.3945/ajcn.2010.29667
   Cuevas-Ramos D, 2010, EUR J ENDOCRINOL, V163, P469, DOI 10.1530/EJE-10-0454
   Di Renzo L, 2010, OBESITY, V18, P2125, DOI 10.1038/oby.2010.50
   Donath MY, 2011, NAT REV IMMUNOL, V11, P98, DOI 10.1038/nri2925
   Drucker DJ, 2006, LANCET, V368, P1696, DOI 10.1016/S0140-6736(06)69705-5
   Duez H, 2012, BIOCHEM PHARMACOL, V83, P823, DOI 10.1016/j.bcp.2011.11.028
   El-Mesallamy HO, 2011, DIABETIC MED, V28, P1194, DOI 10.1111/j.1464-5491.2011.03353.x
   Engl J, 2008, OBESITY, V16, P1838, DOI 10.1038/oby.2008.273
   Engl J, 2009, EUR J NUTR, V48, P403, DOI 10.1007/s00394-009-0027-9
   Floegel A, 2012, DIABETES
   Galili O, 2007, AM J PHYSIOL-HEART C, V292, pH904, DOI 10.1152/ajpheart.00628.2006
   Hivert MF, 2008, J CLIN ENDOCR METAB, V93, P3165, DOI 10.1210/jc.2008-0425
   Horakova D, 2011, BIOMED PAP, V155, P355, DOI 10.5507/bp.2011.042
   Horakova D, 2010, BIOMED PAP, V154, P245, DOI 10.5507/bp.2010.037
   Hui XY, 2010, J BIOL CHEM, V285, P10273, DOI 10.1074/jbc.M109.097907
   Iglesias P, 2012, EUR J ENDOCRINOL, V167, P301, DOI 10.1530/EJE-12-0357
   Indulekha Karunakaran, 2011, J Diabetes Sci Technol, V5, P982
   Kelly KR, 2010, OBESITY, V18, P663, DOI 10.1038/oby.2009.328
   Kohn LD, 2005, ENDOCRINOLOGY, V146, P4189, DOI 10.1210/en.2005-0920
   Kotnik P, 2011, EUR J ENDOCRINOL, V165, P703, DOI 10.1530/EJE-11-0431
   Kralisch S, 2012, DIABETOLOGIA
   Lamers D, 2011, DIABETES, V60, P1917, DOI 10.2337/db10-1707
   Li K, 2011, EUR J ENDOCRINOL, V164, P905, DOI 10.1530/EJE-10-1023
   Maghbooli Z, 2010, REPROD SCI, V17, P196, DOI 10.1177/1933719109351097
   Moreno-Navarrete JM, 2011, OBESITY, V19, P1552, DOI 10.1038/oby.2010.351
   Miazgowski T, 2012, POL ARCH MED WEWN, V122, P406, DOI 10.20452/pamw.1375
   Mraz M, 2009, CLIN ENDOCRINOL, V71, P369, DOI 10.1111/j.1365-2265.2008.03502.x
   Nagle CA, 2009, J LIPID RES, V50, pS74, DOI 10.1194/jlr.R800053-JLR200
   Osman MM, 2012, LIFE SCI J, V9, P1098
   Ouwens DM, 2012, ARCH PHYSIOL BIOCHEM, V118, P135, DOI 10.3109/13813455.2012.654800
   Reinehr T, 2012, J CLIN ENDOCR METAB, V97, P2143, DOI 10.1210/jc.2012-1221
   Reinehr T, 2010, J PEDIATR ENDOCR MET, V23, P101
   Rizzo MR, 2012, DIABETES CARE, V35, P2076, DOI 10.2337/dc12-0199
   Sell H, 2009, DIABETES, V58, P2731, DOI 10.2337/db09-0277
   Shah Z, 2011, CIRCULATION, V124, P2339, DOI 10.1161/CIRCULATIONAHA.111.041418
   Shim CY, 2010, YONSEI MED J, V51, P375, DOI 10.3349/ymj.2010.51.3.375
   Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI [10.1172/JCI29069, 10.1016/j.febslet.2007.11.057]
   Simon I, 2009, OBESITY, V17, P1124, DOI 10.1038/oby.2008.665
   Stefanska A, 2011, CLIN BIOCHEM, V44, P304, DOI 10.1016/j.clinbiochem.2010.12.002
   Stejskal D, 2006, EUR J CLIN INVEST, V36, P621, DOI 10.1111/j.1365-2362.2006.01696.x
   Takashima N, 2006, NEW ENGL J MED, V355, P1392
   Tan BK, 2010, TRENDS CARDIOVAS MED, V20, P143, DOI 10.1016/j.tcm.2010.12.002
   Uebanso T, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0022976
   Wada J, 2008, EXPERT OPIN INV DRUG, V17, P327, DOI 10.1517/13543784.17.3.327 
   Wang-Sattler R, 2012, MOL SYST BIOL, V8, DOI 10.1038/msb.2012.43
   Wu B, 2009, ENDOCR J, V56, P773, DOI 10.1507/endocrj.K08E-332
   Wysocki Janusz, 2005, Wiad Lek, V58, P124
   Xu A, 2007, CIRCULATION, V115, P1537, DOI 10.1161/CIRCULATIONAHA.106.647503
   Xu AM, 2006, CLIN CHEM, V52, P405, DOI 10.1373/clinchem.2005.062463
   Yang RZ, 2006, AM J PHYSIOL-ENDOC M, V290, pE1253, DOI 10.1152/ajpendo.00572.2004
   You BS, 2008, DIABETES, V57, P372, DOI 10.2337/db07-1045
   Zhang X, 2008, DIABETES, V57, P1246, DOI 10.2337/db07-1476
   Zhou JY, 2012, CURR VASC PHARM
NR 66
TC 66
Z9 75
U1 0
U2 36
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1434-6621
EI 1437-4331
J9 CLIN CHEM LAB MED
JI Clin. Chem. Lab. Med.
PD JAN
PY 2013
VL 51
IS 1
BP 177
EP 185
DI 10.1515/cclm-2012-0490
PG 9
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 056NP
UT WOS:000312497600017
PM 23241684
OA Bronze
DA 2025-06-11
ER

PT J
AU Cho, HS
   Lee, SW
   Kim, ES
   Shin, J
   Moon, SD
   Han, JH
   Cha, BY
AF Cho, Hyun Sun
   Lee, Sung Won
   Kim, Eun Sook
   Shin, Juyoung
   Moon, Sung Dae
   Han, Je Ho
   Cha, Bong Yun
TI Serum bilirubin levels are inversely associated with PAI-1 and
   fibrinogen in Korean subjects
SO ATHEROSCLEROSIS
LA English
DT Article
DE Bilirubin; Plasminogen activator inhibitor-1; Fibrinogen;
   Atherosclerosis
ID GILBERTS-SYNDROME; CARDIOVASCULAR PROTECTION; PLATELET ACTIVATION;
   METABOLIC SYNDROME; OXIDATIVE STRESS; UNCONJUGATED BILIRUBIN;
   MYOCARDIAL-INFARCTION; INSULIN-RESISTANCE; HEART-DISEASE; RISK
AB Objectives: Oxidative stress may contribute to atherosclerosis and increased activation of the coagulation pathway. Bilirubin may reduce activation of the hemostatic system to inhibit oxidative stress, which would explain its cardioprotective properties shown in many epidemiological studies. This study investigated the association of serum bilirubin with fibrinogen and plasminogen activator inhibitor-1 (PAI-1), respectively.
   Methods: A cross-sectional analysis was performed on 968 subjects (mean age, 56.0 +/- 11.2 years; 61.1% men) undergoing a general health checkup. Serum biochemistry was analyzed including bilirubin sub-types, insulin resistance (using homeostasis model of assessment [HOMA]), C-reactive protein (CRP), fibrinogen, and PAI-1.
   Results: Compared with subjects with a total bilirubin (TB) concentration of <10.0 mu mol/L, those with a TB concentration of >17.1 mu mol/L had a smaller waist circumference, a lower triglyceride level, a lower prevalence of metabolic syndrome, and decreased HOMA-IR and CRP levels. Correlation analysis revealed linear relationships of fibrinogen with TB and direct bilirubin (DB), whereas PAI-1 was correlated with DB. After adjustment for confounding factors, bilirubin levels were inversely associated with fibrinogen and PAI-1 levels, respectively. Multivariate regression models showed a negative linear relationship between all types of bilirubin and fibrinogen, whereas there was a significant linear relationship between PAI-1 and DB.
   Conclusions: High bilirubin concentrations were independently associated with low levels of fibrinogen and PAI-1, respectively. The association between TB and PAI-1 was confined to the highest TB concentration category whereas DB showed a linear association with PAI-1. Bilirubin may protect against the development of atherothrombosis by reducing the hemostatic response. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Cho, Hyun Sun; Lee, Sung Won; Kim, Eun Sook; Shin, Juyoung; Moon, Sung Dae; Han, Je Ho; Cha, Bong Yun] Catholic Univ Korea, Dept Internal Med, Coll Med, Seoul 137701, South Korea.
   [Kim, Eun Sook; Moon, Sung Dae; Han, Je Ho] Catholic Univ Korea, Dept Internal Med, Coll Med, Div Endocrinol & Metab, Seoul 137701, South Korea.
   [Lee, Sung Won] Catholic Univ Korea, Dept Internal Med, Coll Med, Div Hepatol, Seoul 137701, South Korea.
   [Cho, Hyun Sun; Shin, Juyoung] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Hlth Promot Ctr, Seoul 137701, South Korea.
C3 Catholic University of Korea; Catholic University of Korea; Catholic
   University of Korea; Seoul St. Mary's Hospital; Catholic University of
   Korea
RP Kim, ES (corresponding author), Catholic Univ Korea, Dept Internal Med, Incheon St Marys Hosp, Div Endocrinol & Metab,Coll Med, 222 Banpo Daero, Seoul 137701, South Korea.
EM 13900@catholic.ac.kr
RI Kim, Jang-Hee/AAI-9917-2020
FU National Research Foundation of Korea (NRF) grant - Korea government
   (MSIP) [2014R1A1A1006144]
FX This study was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korea government (MSIP, 2014R1A1A1006144).
CR Bisht K, 2014, BIOCHEM BIOPH RES CO, V449, P94, DOI 10.1016/j.bbrc.2014.04.150
   Bonora E, 1998, DIABETES, V47, P1643, DOI 10.2337/diabetes.47.10.1643
   Boon AC, 2012, FREE RADICAL BIO MED, V52, P2120, DOI 10.1016/j.freeradbiomed.2012.03.002
   Borissoff JI, 2010, CIRCULATION, V122, P821, DOI 10.1161/CIRCULATIONAHA.109.907121
   Bulmer AC, 2013, PROG LIPID RES, V52, P193, DOI 10.1016/j.plipres.2012.11.001
   Bulmer AC, 2008, ATHEROSCLEROSIS, V199, P390, DOI 10.1016/j.atherosclerosis.2007.11.022
   Celik T, 2014, ANGIOLOGY, V65, P198, DOI 10.1177/0003319712474948
   Cho HS, 2015, NUTR METAB CARDIOVAS, V25, P677, DOI 10.1016/j.numecd.2015.03.014
   Darvall KAL, 2007, EUR J VASC ENDOVASC, V33, P223, DOI 10.1016/j.ejvs.2006.10.006
   Davì G, 2007, NEW ENGL J MED, V357, P2482, DOI 10.1056/NEJMra071014
   de Moerloose P, 2010, SEMIN THROMB HEMOST, V36, P7, DOI 10.1055/s-0030-1248720
   Demir Mehmet, 2013, Ther Adv Cardiovasc Dis, V7, P316, DOI 10.1177/1753944713514473
   Dong HS, 2014, ENDOCRINOLOGY, V155, P818, DOI 10.1210/en.2013-1667
   Empana JP, 2008, EUR HEART J, V29, P1966, DOI 10.1093/eurheartj/ehn331
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hopkins PN, 1996, ARTERIOSCL THROM VAS, V16, P250, DOI 10.1161/01.ATV.16.2.250
   Horsfall LJ, 2013, J GASTROEN HEPATOL, V28, P1643, DOI 10.1111/jgh.12279
   Horsfall LJ, 2012, CIRCULATION, V126, P2556, DOI 10.1161/CIRCULATIONAHA.112.114066
   Horsfall LJ, 2011, JAMA-J AM MED ASSOC, V305, P691, DOI 10.1001/jama.2011.124
   Hwang HJ, 2011, CLIN CHEM LAB MED, V49, P1823, DOI 10.1515/CCLM.2011.662
   Hwang HJ, 2010, CLIN CHIM ACTA, V411, P1496, DOI 10.1016/j.cca.2010.06.003
   Inoguchi T, 2007, JAMA-J AM MED ASSOC, V298, P1398, DOI 10.1001/jama.298.12.1398-b
   Jangi S, 2013, INT J BIOCHEM CELL B, V45, P2843, DOI 10.1016/j.biocel.2013.09.014
   Jo Jaeseong, 2012, J Prev Med Public Health, V45, P105, DOI 10.3961/jpmph.2012.45.2.105
   Jo J, 2011, ENDOCRINE, V39, P182, DOI 10.1007/s12020-010-9417-2
   Khrenov AV, 2002, TRENDS CARDIOVAS MED, V12, P317, DOI 10.1016/S1050-1738(02)00182-2
   Kim ES, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0109251
   Kimm H, 2009, STROKE, V40, P3422, DOI 10.1161/STROKEAHA.109.560649
   Kundur AR, 2015, ATHEROSCLEROSIS, V239, P73, DOI 10.1016/j.atherosclerosis.2014.12.042
   Kundur AR, 2014, PLATELETS, V25, P45, DOI 10.3109/09537104.2013.764405
   Lin LY, 2009, ATHEROSCLEROSIS, V203, P563, DOI 10.1016/j.atherosclerosis.2008.07.021
   Lindenblatt N, 2004, ARTERIOSCL THROM VAS, V24, P601, DOI 10.1161/01.ATV.0000118279.74056.8a
   Lippi G, 2009, LIVER INT, V29, P315, DOI 10.1111/j.1478-3231.2008.01821.x
   Lowe G, 2011, INTERN EMERG MED, V6, P497, DOI 10.1007/s11739-011-0536-4
   Madamanchi NR, 2005, ARTERIOSCLER THROMB, V25, P1
   Maruhashi T, 2012, CIRCULATION, V126, P598, DOI 10.1161/CIRCULATIONAHA.112.105775
   Ocadlík I, 2011, NEUROENDOCRINOL LETT, V32, P360
   Oz F, 2015, KARDIOL POL, V73, P40, DOI 10.5603/KP.a2014.0117
   Perlstein T., 2008, ARTERIOSCLER THROMB, V28, P166, DOI DOI 10.1161/ATVBAHA.107.153262
   Pineda Sandra, 2008, J Stroke Cerebrovasc Dis, V17, P147, DOI 10.1016/j.jstrokecerebrovasdis.2008.01.009
   Ryu S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0075178
   Santhakumar AB, 2014, J HUM NUTR DIET, V27, P1, DOI 10.1111/jhn.12177
   Schwertner HA, 2008, ATHEROSCLEROSIS, V198, P1, DOI 10.1016/j.atherosclerosis.2008.01.001
   Stevens LA, 2006, NEW ENGL J MED, V354, P2473, DOI 10.1056/NEJMra054415
   Sung KC, 2013, AM J CARDIOL, V112, P1873, DOI 10.1016/j.amjcard.2013.08.018
   SUVANSRI U, 1969, J PEDIATR, V74, P240, DOI 10.1016/S0022-3476(69)80071-5
   Tapan S, 2011, CLIN BIOCHEM, V44, P300, DOI 10.1016/j.clinbiochem.2010.12.003
   Tapan S, 2009, CLIN BIOCHEM, V42, P791, DOI 10.1016/j.clinbiochem.2009.02.005
   Tiker Filiz, 2005, Indian Journal of Pediatrics, V72, P205
   Tomaro ML, 2002, INT J BIOCHEM CELL B, V34, P216, DOI 10.1016/S1357-2725(01)00130-3
   Tzoulaki I, 2007, CIRCULATION, V115, P2119, DOI 10.1161/CIRCULATIONAHA.106.635029
   Vítek L, 2002, ATHEROSCLEROSIS, V160, P449, DOI 10.1016/S0021-9150(01)00601-3
   Vítek L, 2007, J GASTROEN HEPATOL, V22, P841, DOI 10.1111/j.1440-1746.2006.04564.x
   Wallner M, 2013, CLIN SCI, V125, P257, DOI 10.1042/CS20120661
   Wannamethee SG, 2009, J THROMB HAEMOST, V7, P1605, DOI 10.1111/j.1538-7836.2009.03574.x
   Willeit P, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0055175
   Wu ML, 2011, ANTIOXID REDOX SIGN, V15, P1835, DOI 10.1089/ars.2010.3726
   Wu TW, 1996, BIOCHEM PHARMACOL, V51, P859, DOI 10.1016/0006-2952(95)02395-X
   Xu X, 2009, EXP LUNG RES, V35, P795, DOI 10.3109/01902140902912519
   Yesilova Z, 2008, J GASTROEN HEPATOL, V23, P1556, DOI 10.1111/j.1440-1746.2008.05388.x
   Zakai NA, 2007, J THROMB HAEMOST, V5, P1128, DOI 10.1111/j.1538-7836.2007.02528.x
NR 61
TC 11
Z9 11
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD JAN
PY 2016
VL 244
BP 204
EP 210
DI 10.1016/j.atherosclerosis.2015.11.008
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CZ8UR
UT WOS:000367375100067
PM 26684255
DA 2025-06-11
ER

PT J
AU Karamouzis, I
   Pervanidou, P
   Berardelli, R
   Iliadis, S
   Papassotiriou, I
   Karamouzis, M
   Chrousos, GP
   Kanaka-Gantenbein, C
AF Karamouzis, I.
   Pervanidou, P.
   Berardelli, R.
   Iliadis, S.
   Papassotiriou, I.
   Karamouzis, M.
   Chrousos, G. P.
   Kanaka-Gantenbein, C.
TI Enhanced Oxidative Stress and Platelet Activation Combined with Reduced
   Antioxidant Capacity in Obese Prepubertal and Adolescent Girls with Full
   or Partial Metabolic Syndrome
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE antioxidant state; isoprostane; thromboxane; pediatric obesity; carbonyl
   proteins
ID INTIMA-MEDIA THICKNESS; PROTEIN-KINASE-C; ALPHA-TOCOPHEROL;
   INSULIN-RESISTANCE; BETA-CAROTENE; CARDIOVASCULAR-DISEASE;
   LIPID-PEROXIDATION; OXIDANT STRESS; ISOPROSTANES; THROMBOXANE
AB In adults, obesity is a main factor implicated in increased oxidative stress (OS), platelet activation (PA) and impaired antioxidant status (AS), all predisposing factors for cardiovascular disease leading to increased morbidity and mortality. Furthermore, the metabolic syndrome (MetS) is an important cardiovascular risk factor, which progressively develops and may already be present during late childhood or adolescence. However, scarce data exist on oxidative-antioxidant balance and PA in childhood and adolescence in the presence of partial (PMetS) or full MetS. The aim of the study was to evaluate OS, PA, and AS in prepubertal and adolescent obese girls with partial or full MetS. 96 girls with a clinical and metabolic evaluation for obesity and 44 healthy normal-weight sex-and age-matched girls were studied. IDF-adopted criteria were used to define full and partial MetS and the patient population was divided into 4 groups: the first comprised 31 pre-pubertal girls with PMetS (PR-PMetS), the second 37 adolescents with PMetS (AD-PMetS), the third 10 prepubertal girls with full MetS (PR-MetS), and the fourth 18 adolescents with full MetS (AD-MetS). The OS was evaluated by measuring plasma 15-F-2t-Isoprostane levels (15-F-2t-IsoP) and protein carbonyls, PA by thromboxane B-2 levels (TXB2), and AS by serum vitamin E and plasma total antioxidant capacity (TAC) levels. 15-F-2t-IsoP, protein carbonyls, and TXB2 levels were significantly gradually amplified, and vitamin E and TAC reduced, and significantly correlated with obesity from childhood to adolescence and from partial to full MetS. This study demonstrates the loss of the normal homeostatic balance between oxidant-antioxidant state in obese children and adolescents with manifestations of partial and full MetS.
C1 [Karamouzis, I.; Pervanidou, P.; Chrousos, G. P.; Kanaka-Gantenbein, C.] Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Div Endocrinol Diabet & Metab,Dept Pediat 1, GR-11527 Athens, Greece.
   [Berardelli, R.] Univ Turin, Dept Internal Med, Div Endocrinol Diabet & Metab, I-10124 Turin, Italy.
   [Iliadis, S.; Karamouzis, M.] Aristotle Univ Thessaloniki, Biol Chem Lab, Fac Med, Thessaloniki, Greece.
   [Papassotiriou, I.] Aghia Sophia Childrens Hosp, Dept Clin Biochem, Athens, Greece.
C3 Athens Medical School; The Aghia Sophia Children's Hospital; National &
   Kapodistrian University of Athens; University of Turin; Aristotle
   University of Thessaloniki; The Aghia Sophia Children's Hospital
RP Kanaka-Gantenbein, C (corresponding author), Thivon & Papadiamantopoulou Goudi, Athens 11527, Greece.
EM ganten@hol.gr
RI Kanaka-Gantenbein, Christina/AAP-3697-2020; Pervanidou,
   Panagiota/ABI-6356-2020
OI Pervanidou, Panagiota/0000-0002-6593-6489; ILIADIS,
   STAVROS/0000-0001-6671-1401
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   [Anonymous], 1999, Report of a WHO Consultation, P59
   ARNAUD J, 1991, J CHROMATOGR-BIOMED, V572, P103, DOI 10.1016/0378-4347(91)80476-S
   Balkau B, 1999, DIABETIC MED, V16, P442
   Basili S, 2006, J AM COLL CARDIOL, V48, P2531, DOI 10.1016/j.jacc.2006.08.040
   Chiotis D., 2004, Ann. Clin. Pediatr. Univ. Atheniensis, V51, P139
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Codoñer-Franch P, 2010, INT J PEDIATR OBES, V5, P56, DOI 10.3109/17477160903055945
   CODONERFRANCH P, 2010, NUTR METAB CARD 0812
   Cole TJ, 2000, BMJ-BRIT MED J, V320, P1240, DOI 10.1136/bmj.320.7244.1240
   Cosentino F, 2003, CIRCULATION, V107, P1017, DOI 10.1161/01.CIR.0000051367.92927.07
   Cracowski JL, 2002, TRENDS PHARMACOL SCI, V23, P360, DOI 10.1016/S0165-6147(02)02053-9
   Davì G, 2005, LUPUS, V14, P760, DOI 10.1191/0961203305lu2216oa
   Davì G, 2002, JAMA-J AM MED ASSOC, V288, P2008, DOI 10.1001/jama.288.16.2008
   Dogné JM, 2005, TRENDS PHARMACOL SCI, V26, P639, DOI 10.1016/j.tips.2005.10.001
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   Freedman JE, 1996, CIRCULATION, V94, P2434, DOI 10.1161/01.CIR.94.10.2434
   Giannini C, 2009, EUR J ENDOCRINOL, V161, P73, DOI 10.1530/EJE-09-0042
   Giannini C, 2008, ATHEROSCLEROSIS, V197, P448, DOI 10.1016/j.atherosclerosis.2007.06.023
   Haffner SM, 2006, AM J MED, V119, p3S, DOI 10.1016/j.amjmed.2006.01.008
   Hayden MR, 2005, AM J NEPHROL, V25, P553, DOI 10.1159/000088810
   Hunt KJ, 2004, CIRCULATION, V110, P1251, DOI 10.1161/01.CIR.0000140762.04598.F9
   Isomaa B, 2001, DIABETES CARE, V24, P683, DOI 10.2337/diacare.24.4.683
   Jaffar NZ, 2006, CLIN BIOCHEM, V39, P55, DOI 10.1016/j.clinbiochem.2005.09.011
   JIALAL I, 1995, ARTERIOSCL THROM VAS, V15, P190, DOI 10.1161/01.ATV.15.2.190
   Karamouzis I, 2008, HORM-INT J ENDOCRINO, V7, P62, DOI 10.14310/horm.2002.1111038
   Karamouzis I, 2008, AM J NEPHROL, V28, P397, DOI 10.1159/000112413
   Karamouzis I, 2009, HORM-INT J ENDOCRINO, V8, P129, DOI 10.14310/horm.2002.1229
   Katugampola SD, 2001, BRIT J PHARMACOL, V134, P1385, DOI 10.1038/sj.bjp.0704416
   Kaufman CL, 2007, OBESITY, V15, P1164, DOI 10.1038/oby.2007.619
   Kelly Aaron S, 2006, J Cardiometab Syndr, V1, P248, DOI 10.1111/j.1559-4564.2006.05758.x
   Knight J.A., 1999, FREE RADICALS ANTIOX, P21
   Koh KK, 2009, CARDIOVASC RES, V81, P649, DOI 10.1093/cvr/cvn354
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lawson JA, 1999, J BIOL CHEM, V274, P24441, DOI 10.1074/jbc.274.35.24441
   LEVINE RL, 1994, METHOD ENZYMOL, V233, P346
   Miller NJ, 1997, FREE RADICAL RES, V26, P195, DOI 10.3109/10715769709097799
   Mohn A, 2005, J CLIN ENDOCR METAB, V90, P2653, DOI 10.1210/jc.2004-2178
   Montuschi P, 2004, FASEB J, V18, P1791, DOI 10.1096/fj.04-2330rev
   Morinobu T, 2002, INT J VITAM NUTR RES, V72, P119, DOI 10.1024/0300-9831.72.3.119
   Morrow JD, 2005, ARTERIOSCL THROM VAS, V25, P279, DOI 10.1161/01.ATV.0000152605.64964.c0
   Morrow JD, 1996, J BIOL CHEM, V271, P23185, DOI 10.1074/jbc.271.38.23185
   MORROW JD, 1990, P NATL ACAD SCI USA, V87, P9383, DOI 10.1073/pnas.87.23.9383
   Nakahata N, 2008, PHARMACOL THERAPEUT, V118, P18, DOI 10.1016/j.pharmthera.2008.01.001
   Perticone F, 2001, DIABETES, V50, P159, DOI 10.2337/diabetes.50.1.159
   PRATICO D, 1995, J BIOL CHEM, V270, P9800, DOI 10.1074/jbc.270.17.9800
   Puchau B, 2010, INT J FOOD SCI NUTR, V61, P713, DOI 10.3109/09637481003757860
   Roberts LJ, 2000, FREE RADICAL BIO MED, V28, P505, DOI 10.1016/S0891-5849(99)00264-6
   Rokach J, 1997, PROSTAG OTH LIPID M, V54, P823, DOI 10.1016/S0090-6980(97)00183-4
   Sattar N, 2003, CIRCULATION, V108, P414, DOI 10.1161/01.CIR.0000080897.52664.94
   STADTMAN ER, 1991, J BIOL CHEM, V266, P2005
   Strauss RS, 1999, J PEDIATR-US, V134, P160, DOI 10.1016/S0022-3476(99)70409-9
   Tanner J.M., 1962, Growth at Adolescence, V2nd ed.
   Tinahones FJ, 2009, OBESITY, V17, P240, DOI 10.1038/oby.2008.536
   Uauy R., 2004, OBES REV INTERNET, V5, P4, DOI [10.1111/j.1467-789X.2004.00133.x, DOI 10.1111/J.1467-789X.2004.00133.X]
   Urakawa H, 2003, J CLIN ENDOCR METAB, V88, P4673, DOI 10.1210/jc.2003-030202
   Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
   van Kraaij DJW, 2002, BRIT J CLIN PHARMACO, V53, P644, DOI 10.1046/j.1365-2125.2002.01605.x
   Wang Y, 2006, INT J PEDIATR OBES, V1, P11, DOI 10.1080/17477160600586747
   WHO Consultation, 2000, WHO TECH REP SER, V894, P1
   Williams IL, 2002, INT J OBESITY, V26, P754, DOI 10.1038/sj.ijo.0801995
   Zimmet P, 2007, PEDIATR DIABETES, V8, P299, DOI 10.1111/j.1399-5448.2007.00271.x
NR 62
TC 35
Z9 38
U1 0
U2 4
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD AUG
PY 2011
VL 43
IS 9
BP 607
EP 613
DI 10.1055/s-0031-1284355
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 803IJ
UT WOS:000293574700003
PM 21823055
DA 2025-06-11
ER

PT J
AU Kopp, W
AF Kopp, Wolfgang
TI How Western Diet And Lifestyle Drive The Pandemic Of Obesity And
   Civilization Diseases
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE diabetes; obesity; metabolic syndrome; insulin hypersecretion; oxidative
   stress; paleolithic diet; pathogenesis
ID RENIN-ANGIOTENSIN SYSTEM; SYMPATHETIC-NERVOUS-SYSTEM; INDUCED
   INSULIN-RESISTANCE; POLYCYSTIC-OVARY-SYNDROME; OXIDATIVE STRESS;
   HIGH-FAT; ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; CHRONIC
   INFLAMMATION; CIGARETTE-SMOKING
AB Westernized populations are plagued by a plethora of chronic non-infectious degenerative diseases, termed as "civilization diseases", like obesity, diabetes, cardiovascular diseases, cancer, autoimmune diseases, Alzheimer's disease and many more, diseases which are rare or virtually absent in hunter-gatherers and other non-westernized populations. There is a growing awareness that the cause of this amazing discrepancy lies in the profound changes in diet and lifestyle during recent human history. This paper shows that the transition from Paleolithic nutrition to Western diets, along with lack of corresponding genetic adaptations, cause significant distortions of the fine-tuned metabolism that has evolved over millions of years of human evolution in adaptation to Paleolithic diets. With the increasing spread of Western diet and lifestyle worldwide, overweight and civilization diseases are also rapidly increasing in developing countries. It is suggested that the diet-related key changes in the developmental process include an increased production of reactive oxygen species and oxidative stress, development of hyperinsulinemia and insulin resistance, low-grade inflammation and an abnormal activation of the sympathetic nervous system and the renin-angiotensin system, all of which play pivotal roles in the development of diseases of civilization. In addition, diet-related epigenetic changes and fetal programming play an important role. The suggested pathomechanism is also able to explain the well-known but not completely understood close relationship between obesity and the wide range of comorbidities, like type 2 diabetes mellitus, cardiovascular disease, etc., as diseases of the same etiopathology. Changing our lifestyle in accordance with our genetic makeup, including diet and physical activity, may help prevent or limit the development of these diseases.
C1 [Kopp, Wolfgang] Diagnost Zentrum Graz, A-8043 Graz, Austria.
RP Kopp, W (corresponding author), Mariatrosterstr 41, A-8043 Graz, Austria.
EM w.kopp@weiz.cc
OI Kopp, Wolfgang/0000-0002-8869-5470
CR Afshin A, 2017, NEW ENGL J MED, V377, P13, DOI 10.1056/NEJMoa1614362
   Alfaradhi Maria Z., 2011, Frontiers in Genetics, V2, P27, DOI 10.3389/fgene.2011.00027
   Almeida-Santos AF, 2017, PROTEIN PEPTIDE LETT, V24, P841, DOI 10.2174/0929866524666170822120258
   [Anonymous], 2016, J NUTR DISORDERS THE, DOI DOI 10.4172/2161-0509.1000185
   [Anonymous], 2015, BIOTECHNOLOGY WORLD, DOI DOI 10.1371/J0URNAL.P0NE.0127389
   [Anonymous], 2014, ESSENTIAL CELL BIOL
   Arcaro G, 2002, CIRCULATION, V105, P576, DOI 10.1161/hc0502.103333
   Baena M, 2016, SCI REP-UK, V6, DOI 10.1038/srep26149
   Barnard RJ, 1998, J APPL PHYSIOL, V84, P1311, DOI 10.1152/jappl.1998.84.4.1311
   Björck I, 2000, BRIT J NUTR, V83, pS149
   Bray GA, 2004, AM J CLIN NUTR, V79, P537
   Brown DI, 2015, CIRC RES, V116, P531, DOI 10.1161/CIRCRESAHA.116.303584
   Busserolles J, 2002, BRIT J NUTR, V87, P337, DOI 10.1079/BJNBJN2002524
   Calder PC, 2013, BRIT J NUTR, V109, pS1, DOI 10.1017/S0007114512005119
   Calkins K, 2011, CURR PROB PEDIATR AD, V41, P158, DOI 10.1016/j.cppeds.2011.01.001
   CAMPBELL PJ, 1992, AM J PHYSIOL, V263, pE1063
   Carnethon MR, 2003, CIRCULATION, V107, P2190, DOI 10.1161/01.CIR.0000066324.74807.95
   Carrera-Bastos P, 2011, RES REP CLIN CARDIOL, V2, P15, DOI 10.2147/RRCC.S16919
   Catalano KJ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0108693
   Castro MC, 2015, LIFE SCI, V137, P1, DOI 10.1016/j.lfs.2015.07.010
   Cetin I, 2015, J PEDIATR NEONATAL I, V4, DOI 10.7363/040220
   Chan SMH, 2017, ENDOCRINOLOGY, V158, P3162, DOI 10.1210/en.2016-1879
   Chawla T, 2010, WORLD J DIABETES, V1, P141, DOI 10.4239/wjd.v1.i5.141
   Choquet H, 2011, CURR GENOMICS, V12, P169, DOI 10.2174/138920211795677895
   Christ A, 2018, CELL, V172, P162, DOI 10.1016/j.cell.2017.12.013
   Coelho M, 2013, ARCH MED SCI, V9, P191, DOI 10.5114/aoms.2013.33181
   Cohen DH, 2012, ENDOCR-RELAT CANCER, V19, pF27, DOI 10.1530/ERC-11-0374
   Cordain L, 2005, AM J CLIN NUTR, V81, P341, DOI 10.1093/ajcn.81.2.341
   Cordain L, 2000, AM J CLIN NUTR, V71, P682, DOI 10.1093/ajcn/71.3.682
   Corkey BE, 2012, DIABETES, V61, P4, DOI 10.2337/db11-1483
   Cusin Isabelle, 1992, International Journal of Obesity, V16, pS1
   Dankner R, 2009, DIABETES CARE, V32, P1464, DOI 10.2337/dc09-0153
   De Filippis Francesca, 2016, Gut, V65, P1812, DOI 10.1136/gutjnl-2015-309957
   Desai M, 2014, AM J OBSTET GYNECOL, V211, DOI 10.1016/j.ajog.2014.03.025
   DiMeglio DP, 2000, INT J OBESITY, V24, P794, DOI 10.1038/sj.ijo.0801229
   DiNicolantonio JJ, 2018, OPEN HEART, V5, DOI 10.1136/openhrt-2018-000898
   Drewnowski A, 2003, LIPIDS, V38, P109, DOI 10.1007/s11745-003-1039-3
   Drews G, 2010, PFLUG ARCH EUR J PHY, V460, P703, DOI 10.1007/s00424-010-0862-9
   EATON SB, 1985, NEW ENGL J MED, V312, P283, DOI 10.1056/NEJM198501313120505
   EATON SB, 1988, AM J MED, V84, P739, DOI 10.1016/0002-9343(88)90113-1
   ECKEL RH, 1992, LANCET, V340, P1452, DOI 10.1016/0140-6736(92)92633-Q
   Erdelyi I, 2009, J NUTR, V139, P2072, DOI 10.3945/jn.108.104125
   Erion KA, 2017, CURR OBES REP, V6, P178, DOI 10.1007/s13679-017-0261-z
   Esmaillzadeh A, 2007, AM J CLIN NUTR, V85, P910, DOI 10.1093/ajcn/85.3.910
   Esser N, 2014, DIABETES RES CLIN PR, V105, P141, DOI 10.1016/j.diabres.2014.04.006
   FACCHINI FS, 1992, LANCET, V339, P1128, DOI 10.1016/0140-6736(92)90730-Q
   Ferrannini E, 2004, DIABETES, V53, pS26, DOI 10.2337/diabetes.53.suppl_3.S26
   Fishel MA, 2005, ARCH NEUROL-CHICAGO, V62, P1539, DOI 10.1001/archneur.62.10.noc50112
   Fitzgerald PJ, 2010, CURR ALZHEIMER RES, V7, P506
   Flaa A, 2008, METABOLISM, V57, P1422, DOI 10.1016/j.metabol.2008.05.012
   Frassetto LA, 2009, EUR J CLIN NUTR, V63, P947, DOI 10.1038/ejcn.2009.4
   Fung J., 2016, J Insulin Resist, V1, pa18, DOI [DOI 10.4102/JIR.V1I1.18, 10.4102/jir.v1i1.1]
   Gamboa A, 2014, HYPERTENSION, V64, P867, DOI 10.1161/HYPERTENSIONAHA.114.03738
   GARN SM, 1989, NUTR REV, V47, P337
   Ge XM, 2008, FREE RADICAL RES, V42, P582, DOI 10.1080/10715760802158448
   Gebre AK, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00440
   George AJ, 2010, NAT REV CANCER, V10, P745, DOI 10.1038/nrc2945
   Candela CG, 2011, NUTR HOSP, V26, P323, DOI [10.1590/S0212-16112011000200013, 10.3305/nh.2011.26.2.5117]
   Gomolak JR, 2014, FRONT PHYSIOL, V5, DOI 10.3389/fphys.2014.00396
   Gonsolin D, 2007, MOL CELL BIOCHEM, V295, P217, DOI 10.1007/s11010-006-9291-7
   Gonzalez A, 2013, ENDOCRINOLOGY, V154, P3515, DOI 10.1210/en.2013-1424
   González K, 2017, KOREAN J FAM MED, V38, P111, DOI 10.4082/kjfm.2017.38.3.111
   Gough DR, 2011, CELL DEATH DIS, V2, DOI 10.1038/cddis.2011.96
   Grassi G, 2001, J HYPERTENS, V19, P1713, DOI 10.1097/00004872-200110000-00003
   Grassi G, 2009, J NEPHROL, V22, P190
   GRIMDITCH GK, 1988, AM J CLIN NUTR, V48, P38, DOI 10.1093/ajcn/48.1.38
   GRUNFELD B, 1994, HYPERTENSION, V23, pI12, DOI 10.1161/01.HYP.23.1_Suppl.I12
   Gurven M, 2007, POPUL DEV REV, V33, P321, DOI 10.1111/j.1728-4457.2007.00171.x
   Haenni A, 2001, J HYPERTENS, V19, P107, DOI 10.1097/00004872-200101000-00014
   Hales CN, 2001, BRIT MED BULL, V60, P5, DOI 10.1093/bmb/60.1.5
   Hall JE, 2012, COMPR PHYSIOL, V2, P2393, DOI 10.1002/cphy.c110058
   Hay William W Jr, 2006, Trans Am Clin Climatol Assoc, V117, P321
   Heinonen I, 2014, ACTA PHYSIOL, V211, P515, DOI 10.1111/apha.12253
   Henriksen EJ, 2011, FREE RADICAL BIO MED, V51, P993, DOI 10.1016/j.freeradbiomed.2010.12.005
   HESELTINE D, 1990, CLIN SCI, V79, P517, DOI 10.1042/cs0790517
   Hitomi H, 2007, CURR OPIN CARDIOL, V22, P311, DOI 10.1097/HCO.0b013e3281532b53
   HOLT SHA, 1995, APPETITE, V24, P43, DOI 10.1016/S0195-6663(95)80005-0
   Hoppe C, 2005, EUR J CLIN NUTR, V59, P393, DOI 10.1038/sj.ejcn.1602086
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Hu F., 2008, Obesity Epidemiology, P437
   Hunter P, 2012, EMBO REP, V13, P968, DOI 10.1038/embor.2012.142
   James PT, 2001, OBES RES, V9, p228S, DOI 10.1038/oby.2001.123
   Jönsson T, 2006, NUTR METAB, V3, DOI 10.1186/1743-7075-3-39
   Juan CC, 1999, METABOLISM, V48, P465, DOI 10.1016/S0026-0495(99)90105-1
   Karakas M, 2018, EUR HEART J, V39, P70, DOI 10.1093/eurheartj/ehx374
   Karpe F, 2011, DIABETES, V60, P2441, DOI 10.2337/db11-0425
   Khansari N, 2009, RECENT PATENTS INFLA, V3, P73, DOI 10.2174/187221309787158371
   Khoury N, 2011, DIABETES-METAB RES, V27, P604, DOI 10.1002/dmrr.1212
   Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213
   Kopp W, 2003, METABOLISM, V52, P840, DOI 10.1016/S0026-0495(02)05294-0
   Kopp W., 2017, J CARCINOGENSIS MUTA, V8, P303
   Kopp W, 2018, NUTR METAB INSIGHTS, V11, DOI 10.1177/1178638818773072
   Korshunov SS, 1997, FEBS LETT, V416, P15, DOI 10.1016/S0014-5793(97)01159-9
   Kwon Eun Jin, 2017, Obstet Gynecol Sci, V60, P506
   Lacolley P, 2012, CARDIOVASC RES, V95, P194, DOI 10.1093/cvr/cvs135
   Lambert EA, 2015, AM J PHYSIOL-HEART C, V309, pH244, DOI 10.1152/ajpheart.00096.2015
   Lansdown A, 2012, CLIN ENDOCRINOL, V77, P791, DOI 10.1111/cen.12003
   Lavoie JL, 2003, ENDOCRINOLOGY, V144, P2179, DOI 10.1210/en.2003-0150
   Le Stunff C, 2000, NAT GENET, V26, P444, DOI 10.1038/82579
   Lee J, 2012, J DENT RES, V91, P142, DOI 10.1177/0022034511421200
   LEMBO G, 1994, AM J PHYSIOL, V266, pE242, DOI 10.1152/ajpendo.1994.266.2.E242
   LESTUNFF C, 1994, DIABETES, V43, P696, DOI 10.2337/diabetes.43.5.696
   Libby P, 2002, NATURE, V420, P868, DOI 10.1161/ATVBAHA.108.179705
   Liesa M, 2013, CELL METAB, V17, P491, DOI 10.1016/j.cmet.2013.03.002
   Limkunakul C, 2014, NEPHROL DIAL TRANSPL, V29, P1047, DOI 10.1093/ndt/gft489
   Lindeberg S, 2007, DIABETOLOGIA, V50, P1795, DOI 10.1007/s00125-007-0716-y
   Lindeberg SA, 1999, METABOLISM, V48, P1216, DOI 10.1016/S0026-0495(99)90258-5
   Ludwig DS, 2018, JAMA INTERN MED, V178, P1098, DOI 10.1001/jamainternmed.2018.2933
   Lustig RH, 2006, INT J OBESITY, V30, P331, DOI 10.1038/sj.ijo.0803074
   MAHLER RJ, 1981, ACTA DIABETOL LAT, V18, P1, DOI 10.1007/BF02056101
   Malti N, 2014, PLACENTA, V35, P411, DOI 10.1016/j.placenta.2014.03.010
   Manna P, 2015, METAB SYNDR RELAT D, V13, P423, DOI 10.1089/met.2015.0095
   Manson JE, 2019, NEW ENGL J MED, V380, P23, DOI 10.1056/NEJMoa1811403
   Martinez KB, 2017, GUT MICROBES, V8, P130, DOI 10.1080/19490976.2016.1270811
   Mathers JC, 2009, ADV EXP MED BIOL, V646, P119, DOI 10.1007/978-1-4020-9173-5_13
   Matsuzawa-Nagata N, 2008, METABOLISM, V57, P1071, DOI 10.1016/j.metabol.2008.03.010
   Mehran AE, 2012, CELL METAB, V16, P723, DOI 10.1016/j.cmet.2012.10.019
   Monnier L, 2006, JAMA-J AM MED ASSOC, V295, P1681, DOI 10.1001/jama.295.14.1681
   Moosavi Azam, 2016, Iranian Biomedical Journal, V20, P246, DOI 10.22045/ibj.2016.01
   Muoio DM, 2014, CELL, V159, P1253, DOI 10.1016/j.cell.2014.11.034
   Naja F, 2015, BRIT J NUTR, V114, P1909, DOI 10.1017/S0007114515003657
   Narkiewicz K, 1998, CIRCULATION, V98, P528, DOI 10.1161/01.CIR.98.6.528
   Neuhouser ML, 2012, J NUTR, V142, P369, DOI 10.3945/jn.111.149807
   Ning J, 2011, AM J PHYSIOL-ENDOC M, V301, pE391, DOI 10.1152/ajpendo.00164.2011
   Nolan CJ, 2019, DIABETES VASC DIS RE, V16, P118, DOI 10.1177/1479164119827611
   Nordmann AJ, 2006, ARCH INTERN MED, V166, P285, DOI 10.1001/archinte.166.3.285
   O'Keefe JH, 2008, J AM COLL CARDIOL, V51, P249, DOI 10.1016/j.jacc.2007.10.016
   O'Keefe JH, 2004, MAYO CLIN PROC, V79, P101, DOI 10.4065/79.1.101
   Oakes JM, 2018, AM J PHYSIOL-REG I, V315, pR895, DOI 10.1152/ajpregu.00099.2018
   ODEA K, 1984, DIABETES, V33, P596, DOI 10.2337/diabetes.33.6.596
   ODEA K, 1988, MED J AUSTRALIA, V148, P177, DOI 10.5694/j.1326-5377.1988.tb112808.x
   Odeleye OE, 1997, DIABETES, V46, P1341, DOI 10.2337/diabetes.46.8.1341
   Olivares-Reyes JA, 2009, MOL CELL ENDOCRINOL, V302, P128, DOI 10.1016/j.mce.2008.12.011
   Östman EM, 2001, AM J CLIN NUTR, V74, P96
   Pacurari M, 2014, INT J INFLAMM, V2014, DOI 10.1155/2014/689360
   Paknahad Zamzam, 2019, Clin Nutr Res, V8, P64, DOI 10.7762/cnr.2019.8.1.64
   Paris M, 2003, ENDOCRINOLOGY, V144, P2717, DOI 10.1210/en.2002-221112
   Park KH, 2015, J KOREAN MED SCI, V30, P1213, DOI 10.3346/jkms.2015.30.9.1213
   Pasupathi P., 2009, J Pharm Sci Res, V1, P55, DOI DOI 10.1080/08958370701401418
   Patel MS, 2011, ANN NUTR METAB, V58, P18, DOI 10.1159/000328040
   Pawlak DB, 2001, J NUTR, V131, P99, DOI 10.1093/jn/131.1.99
   Pedersen DJ, 2015, MOL METAB, V4, P507, DOI 10.1016/j.molmet.2015.04.003
   PENICAUD L, 1989, AM J PHYSIOL, V257, pE255, DOI 10.1152/ajpendo.1989.257.2.E255
   Perrone S, 2016, J PEDIATR BIOCHEM, V6, P96, DOI 10.1055/s-0036-1593811
   Pi JB, 2007, DIABETES, V56, P1783, DOI 10.2337/db06-1601
   Posa JK, 2014, CELL BIOL INT, V38, P818, DOI 10.1002/cbin.10275
   Prasad K, 2014, INT J ANGIOL, V23, P217, DOI 10.1055/s-0034-1387169
   Preeyasombat C, 2005, J PEDIATR-US, V146, P474, DOI 10.1016/j.jpeds.2004.12.014
   Ramalingam L, 2017, BBA-MOL BASIS DIS, V1863, P1106, DOI 10.1016/j.bbadis.2016.07.019
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   Rasool S, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.01054
   Reaven Gerald, 2005, Diab Vasc Dis Res, V2, P105, DOI 10.3132/dvdr.2005.017
   Reaven GM, 2005, ENDOCRIN METAB CLIN, V34, P49, DOI 10.1016/j.ecl.2004.12.001
   Rehm J, 2011, ALCOHOL RES HEALTH, V34, P135
   Rendel JM, 1970, The Impact of Civilization on the Biology of Man, P27
   Reuter S, 2010, FREE RADICAL BIO MED, V49, P1603, DOI 10.1016/j.freeradbiomed.2010.09.006
   Rkhzay-Jaf J, 2012, CURR CARDIOVASC RISK, V6, P487, DOI 10.1007/s12170-012-0257-x
   RODIN J, 1985, METABOLISM, V34, P826, DOI 10.1016/0026-0495(85)90106-4
   Rodríguez-Rodríguez P, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00602
   ROONEY DP, 1991, EUR J CLIN INVEST, V21, P430, DOI 10.1111/j.1365-2362.1991.tb01391.x
   ROWE JW, 1981, DIABETES, V30, P219, DOI 10.2337/diab.30.3.219
   Rufino AT, 2017, J Funct Morphol Kinesiol, V2, P15, DOI [10.3390/jfmk2020015, DOI 10.3390/JFMK2020015]
   Saadeh M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0030200
   Sarafidis PA, 2007, J CLIN ENDOCR METAB, V92, P379, DOI 10.1210/jc.2006-1819
   SAXENA PR, 1992, J CARDIOVASC PHARM, V19, pS80, DOI 10.1097/00005344-199219006-00013
   Schofield CJ, 2012, DIABETIC MED, V29, P972, DOI 10.1111/j.1464-5491.2012.03655.x
   Schraml E, 2007, EXP GERONTOL, V42, P1072, DOI 10.1016/j.exger.2007.08.003
   Scott EM, 2002, CLIN SCI, V102, P523, DOI 10.1042/CS20010239
   Seaman David R, 2013, J Chiropr Humanit, V20, P27, DOI 10.1016/j.echu.2013.08.001
   Seyfried TN, 2010, NUTR METAB, V7, DOI 10.1186/1743-7075-7-7
   Shield KD, 2013, ADDICTION, V108, P912, DOI 10.1111/add.12112
   Shorakae S, 2015, SEMIN REPROD MED, V33, P257, DOI 10.1055/s-0035-1556568
   Sies H, 2005, J NUTR, V135, P969, DOI 10.1093/jn/135.5.969
   Sigal RJ, 1997, DIABETES, V46, P1025, DOI 10.2337/diabetes.46.6.1025
   Simopoulos AP, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030128
   Singh BM, 2003, ARCH INTERN MED, V163, P1296, DOI 10.1001/archinte.163.11.1296
   Skov J, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00023
   SLEDER J, 1980, METABOLISM, V29, P303, DOI 10.1016/0026-0495(80)90001-3
   Strauss RS, 2001, JAMA-J AM MED ASSOC, V286, P2845, DOI 10.1001/jama.286.22.2845
   Tan BL, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/9719584
   Tang J, 2013, SEMIN CANCER BIOL, V23, P533, DOI 10.1016/j.semcancer.2013.08.009
   Templeman NM, 2017, J ENDOCRINOL, V232, pR173, DOI [10.1530/JOE-16-0449, 10.1530/joe-16-0449]
   Tentolouris N, 2003, METABOLISM, V52, P1426, DOI 10.1016/S0026-0495(03)00322-6
   Thompson LP, 2012, J PREGNANCY, V2012, DOI 10.1155/2012/582748
   Todoric J, 2016, CANCER PREV RES, V9, P895, DOI 10.1158/1940-6207.CAPR-16-0209
   Trnovec T, 2001, Cent Eur J Public Health, V9, P49
   Tzanetakou IP, 2011, OPEN CARDIOVASC MED, V5, P103, DOI 10.2174/1874192401105010103
   van Thiel BS, 2015, EUR J PHARMACOL, V763, P3, DOI 10.1016/j.ejphar.2015.03.090
   Verdile G, 2015, MEDIAT INFLAMM, V2015, DOI 10.1155/2015/105828
   Vigneri R, 2016, J ENDOCRINOL INVEST, V39, P1365, DOI 10.1007/s40618-016-0508-7
   Vlasáková Z, 2004, METABOLISM, V53, P469, DOI 10.1016/j.metabol.2003.10.030
   WELLE S, 1981, METABOLISM, V30, P953, DOI 10.1016/0026-0495(81)90092-5
   Westman EC, 2007, AM J CLIN NUTR, V86, P276, DOI 10.1093/ajcn/86.2.276
   Whalen KA, 2016, J NUTR, V146, P1217, DOI 10.3945/jn.115.224048
   Wolever TMS, 1996, J NUTR, V126, P2807
   Yang XY, 2017, FRONT PHYSIOL, V8, DOI 10.3389/fphys.2017.00600
   Youn JY, 2014, DIABETES, V63, P2344, DOI 10.2337/db13-0719
   Zuo T, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/8589318
NR 198
TC 448
Z9 496
U1 7
U2 109
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2019
VL 12
BP 2221
EP 2236
DI 10.2147/DMSO.S216791
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JG6OT
UT WOS:000492191400001
PM 31695465
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Basile, U
   Bruno, C
   Napodano, C
   Vergani, E
   Pocino, K
   Brunetti, A
   Gulli, F
   Santini, SA
   Mancini, A
AF Basile, Umberto
   Bruno, Carmine
   Napodano, Cecilia
   Vergani, Edoardo
   Pocino, Krizia
   Brunetti, Alessandro
   Gulli, Francesca
   Santini, Stefano Angelo
   Mancini, Antonio
TI Plasmatic free light chains as inflammatory marker in insulin
   resistance: comparison of metabolic syndrome with adult growth hormone
   deficiency
SO BIOFACTORS
LA English
DT Article
DE inflammation; immunoglobulines; personalized medicine; oxidative stress;
   antioxidants
ID OXIDATIVE STRESS; BLOOD-PRESSURE; MAST-CELLS; SERUM; KAPPA;
   INTERLEUKIN-6; PATHOGENESIS; CAPACITY; IGF-1
AB Biological functions of immunoglobulin-free light chains (FLCs), other than in chronic inflammatory diseases, are still poorly defined; the field of insulin resistance (IR) has not been investigated, despite the strict relationships with oxidative stress (OS) and inflammation. Therefore, we evaluated FLCs levels and their relationships with metabolic parameters in adult growth hormone deficiency (GHD) and metabolic syndrome (MetS), both characterized by IR. One hundred subjects were enrolled: group A, patients with GHD [n = 31, 24-69 years, mean +/- SEM body mass index (BMI) 26.8 +/- 1.5 kg/m(2)]; group B, patients with MetS (n = 29, 21-70 years, BMI 31.9 +/- 1.3); group C, controls (N = 40, 21-62 years, BMI 21.6 +/- 1.1). Groups were matched by age range and, for patients, by BMI. Morning blood sample was collected for metabolic parameters and FLCs, assessed by turbidimetric assay. GHD patients show levels of FLCs significantly higher than MetS and controls (mean +/- SEM kappa 37.21 +/- 6.97, 15.27 +/- 0.86, 12.34 +/- 0.85 mg/l; lambda 19.44 +/- 2.61, 11.78 +/- 0.72 and 11.67 +/- 0.77 mg/l; kappa/lambda ratio 1.77 +/- 0.13, 1.38 +/- 0.09; and 1.10 +/- 0.06, respectively); only kappa were higher in MetS versus controls. Therefore, the ratio showed progressive declining values in GHD versus MetS versus controls. Our data show increased FLCs levels in GHD and MetS, with the highest values in the former. Both conditions show OS, but with different molecular patterns. FLCs may contribute to chronic inflammation, leading to OS, and cardiovascular complications of GHD. Prognostic and therapeutic implications require further investigation. (C) 2018 BioFactors
C1 [Basile, Umberto] Fdn Policlin Univ A Gemelli IRCCS, Dept Lab Med, Rome, Italy.
   [Bruno, Carmine; Vergani, Edoardo; Brunetti, Alessandro; Mancini, Antonio] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli IRCCS, Operat Unit Endocrinol, Rome, Italy.
   [Napodano, Cecilia; Pocino, Krizia] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli IRCCS, Dept Internal Med, Rome, Italy.
   [Gulli, Francesca] Osped MG Vannini, Rome, Italy.
   [Santini, Stefano Angelo] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli IRCCS, Inst Biochem & Clin Biochem, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Mancini, A (corresponding author), Largo A Gemelli 8, I-00168 Rome, Italy.
EM antonio.mancini@unicatt.it
RI Bruno, Carmine/CAA-0347-2022; Vergani, Edoardo/JCE-0461-2023; Napodano,
   Cecilia/AAO-6048-2020; Brunetti, Alessandro/HKF-8508-2023; basile,
   umberto/E-1720-2018
OI mancini, antonio/0000-0002-9417-6810; Brunetti,
   Alessandro/0000-0001-6651-4117; Napodano, Cecilia/0000-0002-8720-6284;
   Vergani, Edoardo/0000-0002-8444-0091; basile,
   umberto/0000-0002-8328-2570; Bruno, Carmine/0000-0002-3489-0238
CR Aggarwal R, 2011, ARTHRIT CARE RES, V63, P891, DOI 10.1002/acr.20446
   Basile U, 2017, J IMMUNOL METHODS, V451, P11, DOI 10.1016/j.jim.2017.09.005
   Batuman V., 2006, KIDNEY PLASMA CELL D, P87
   Boivin D, 2004, ARCH BIOCHEM BIOPHYS, V431, P197, DOI 10.1016/j.abb.2004.08.022
   Bozkurt B, 2010, HEART FAIL REV, V15, P331, DOI 10.1007/s10741-009-9140-3
   Chamarthi B, 2011, AM J HYPERTENS, V24, P1143, DOI 10.1038/ajh.2011.113
   Conti E, 2003, DIABETES CARE, V26, P1653, DOI 10.2337/diacare.26.5.1653
   Esparvarinha M, 2017, BIOMED PHARMACOTHER, V91, P632, DOI 10.1016/j.biopha.2017.04.121
   Giustina A, 1995, EUR J ENDOCRINOL, V133, P646, DOI 10.1530/eje.0.1330646
   Giustina A, 2014, ENDOCRINE, V47, P354, DOI 10.1007/s12020-014-0278-y
   He SH, 2004, WORLD J GASTROENTERO, V10, P309
   HUMBERT M, 1995, AM J RESP CRIT CARE, V151, P1628, DOI 10.1164/ajrccm.151.5.7735624
   Hutchison CA, 2008, CLIN J AM SOC NEPHRO, V3, P1684, DOI 10.2215/CJN.02290508
   Kavushansky A, 2013, EUR NEUROPSYCHOPHARM, V23, P1779, DOI 10.1016/j.euroneuro.2012.12.003
   Levin A, 2007, AM J KIDNEY DIS, V49, pS10, DOI 10.1053/j.ajkd.2006.12.004
   Lima VV, 2016, LIFE SCI, V145, P137, DOI 10.1016/j.lfs.2015.12.009
   Mancini A, 2010, J ENDOCRINOL INVEST, V33, P422, DOI 10.1007/BF03346615
   Mancini A., 2015, CLIN NUTR SUPPL 2, V10, P52
   Mancini A, 2008, METABOLISM, V57, P1384, DOI 10.1016/j.metabol.2008.05.007
   Mancini A, 2018, ENDOCRINE, V59, P130, DOI 10.1007/s12020-017-1468-1
   Matsumori A, 2010, CIRC RES, V106, P1533, DOI 10.1161/CIRCRESAHA.110.218438
   PAUL S, 1995, J BIOL CHEM, V270, P15257, DOI 10.1074/jbc.270.25.15257
   Pouvreau C, 2018, J INFLAMM RES, V11, P61, DOI 10.2147/JIR.S148911
   Redegeld FA, 2003, TRENDS IMMUNOL, V24, P181, DOI 10.1016/S1471-4906(03)00059-0
   RICEEVANS C, 1994, METHOD ENZYMOL, V234, P279
   Schutte AE, 2014, HYPERTENSION, V63, P1070, DOI 10.1161/HYPERTENSIONAHA.113.03057
   Sengul S, 2002, KIDNEY INT, V62, P1977, DOI 10.1046/j.1523-1755.2002.00660.x
   SUN M, 1994, J IMMUNOL, V153, P5121
   Teppala S, 2010, DIABETES CARE, V33, P2257, DOI 10.2337/dc10-0770
   Theoharides TC, 2007, IMMUNOL REV, V217, P65, DOI 10.1111/j.1600-065X.2007.00519.x
   Thiagarajan P, 2000, BIOCHEMISTRY-US, V39, P6459, DOI 10.1021/bi992588w
   van den Beucken T, 2001, J MOL BIOL, V310, P591, DOI 10.1006/jmbi.2001.4703
   van der Heijden M, 2006, EUR J PHARMACOL, V533, P319, DOI 10.1016/j.ejphar.2005.12.065
   van Exel E, 2002, DIABETES, V51, P1088, DOI 10.2337/diabetes.51.4.1088
NR 34
TC 15
Z9 15
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-6433
EI 1872-8081
J9 BIOFACTORS
JI Biofactors
PD SEP-OCT
PY 2018
VL 44
IS 5
BP 480
EP 484
DI 10.1002/biof.1444
PG 5
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA GY2JC
UT WOS:000448367400007
PM 30175865
DA 2025-06-11
ER

PT J
AU Zilli, AMH
   Zilli, EM
AF Zilli, Aline M. Hilzendeger
   Zilli, Eduardo M.
TI Review of Evidence and Perspectives of Flavonoids on Metabolic Syndrome
   and Neurodegenerative Disease
SO PROTEIN AND PEPTIDE LETTERS
LA English
DT Review
DE Flavonoids; antioxidant; anti-inflammatory; metabolic syndrome; obesity;
   gut microbiota; dementia
ID LOW-GRADE INFLAMMATION; GUT MICROBIOTA; IN-VITRO; INTESTINAL
   INFLAMMATION; DIETARY FLAVONOIDS; ENERGY-EXPENDITURE; COGNITIVE
   FUNCTION; PHENOLIC-ACIDS; BLOOD-PRESSURE; IMMUNE-SYSTEM
AB Flavonoids are commonly found in fruits, vegetables, and plant-derived foods and may promote various health benefits when included in the diet. The biological activity of flavonoids is normally associated to their potent antioxidant and anti-inflammatory effects, since oxidative stress is associated to conditions such as diabetes, obesity, cardiovascular and neurodegenerative diseases. Additionally, flavonoids may be related to metabolic diseases through their effects on inflammatory mediators and pathways, barrier integrity and gut microbiota composition. The extensive metabolism undergone by flavonoids in humans and the individual differences in their bioavailability to target organs hinder the interpretation of results from cell and animal models. Prospective human studies therefore provide an important perspective. In the field of neurodegenerative disease, carefully designed cohort studies have uncovered important associations between flavonoid intake and reduction in dementia risk, especially regarding specific flavonols, but also anthocyanins. Alternative mechanisms of action, such as changes in the gut microbiota or modulation of the production of toxic proteins, such as amyloid and tau, likely account for an important component of their positive effects, and their elucidation may lead to public health benefits of large magnitude.
C1 [Zilli, Aline M. Hilzendeger; Zilli, Eduardo M.] Univ Texas San Antonio, Hlth & Sci Ctr, Glenn Biggs Inst Alzheimer & Neurodegenerat Dis, San Antonio, TX 78229 USA.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio
RP Zilli, EM (corresponding author), Univ Texas San Antonio, Hlth & Sci Ctr, Glenn Biggs Inst Alzheimer & Neurodegenerat Dis, San Antonio, TX 78229 USA.
EM marqueszilli@uthscsa.edu
OI Marques Zilli, Eduardo/0000-0002-6743-8379
CR Amasheh M, 2012, ANN NY ACAD SCI, V1258, P100, DOI 10.1111/j.1749-6632.2012.06609.x
   Anhê FF, 2015, GUT, V64, P872, DOI 10.1136/gutjnl-2014-307142
   [Anonymous], 2005, DIET GUID AM
   Anstey KJ, 2011, OBES REV, V12, pe426, DOI 10.1111/j.1467-789X.2010.00825.x
   Aura AM, 2005, EUR J NUTR, V44, P133, DOI 10.1007/s00394-004-0502-2
   Azuma T, 2013, J NUTR, V143, P827, DOI 10.3945/jn.113.174508
   Barth SW, 2012, EUR J NUTR, V51, P841, DOI 10.1007/s00394-011-0264-6
   Bell ZW, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-29
   Blaut M, 2007, J NUTR, V137, p751S, DOI 10.1093/jn/137.3.751S
   Bleau C, 2015, DIABETES-METAB RES, V31, P545, DOI 10.1002/dmrr.2617
   Cassidy A, 2017, AM J CLIN NUTR, V105, P10, DOI 10.3945/ajcn.116.136051
   Cermak R, 2006, ARCH ANIM NUTR, V60, P180, DOI 10.1080/17450390500467695
   Chooi YC, 2019, METABOLISM, V92, P6, DOI 10.1016/j.metabol.2018.09.005
   Commenges D, 2000, EUR J EPIDEMIOL, V16, P357, DOI 10.1023/A:1007614613771
   Czank C, 2013, AM J CLIN NUTR, V97, P995, DOI 10.3945/ajcn.112.049247
   Czernichow S, 2011, OBES REV, V12, P680, DOI 10.1111/j.1467-789X.2011.00879.x
   Dallas C, 2014, PHYTOTHER RES, V28, P212, DOI 10.1002/ptr.4981
   de Ferrars RM, 2014, BRIT J PHARMACOL, V171, P3268, DOI 10.1111/bph.12676
   Del Rio D, 2010, BRIT J NUTR, V104, pS67, DOI 10.1017/S0007114510003958
   Devore EE, 2010, ARCH NEUROL-CHICAGO, V67, P819, DOI 10.1001/archneurol.2010.144
   Dhanya R, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00336
   Eid HM, 2017, CURR MED CHEM, V24, P355, DOI 10.2174/0929867323666160909153707
   Estaquio C, 2008, J NUTR, V138, P946, DOI 10.1093/jn/138.5.946
   Eteberria U, 2015, J NUTR BIOCHEM, V26, P651, DOI 10.1016/j.jnutbio.2015.01.002
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Fraga CG, 2011, FREE RADICAL BIO MED, V51, P813, DOI 10.1016/j.freeradbiomed.2011.06.002
   Galleano M, 2012, ANN NY ACAD SCI, V1259, P87, DOI 10.1111/j.1749-6632.2012.06511.x
   GBoDS, 2017, GLOBAL BURDEN DIS ST
   Gil-Cardoso K, 2016, NUTR RES REV, V29, P234, DOI 10.1017/S0954422416000159
   Grobe JL, 2012, HYPERTENSION, V60, P1389, DOI 10.1161/HYPERTENSIONAHA.112.200543
   Guzik TJ, 2006, J PHYSIOL PHARMACOL, V57, P505
   Hebert LE, 2013, NEUROLOGY, V80, P1778, DOI 10.1212/WNL.0b013e31828726f5
   Holland TM, 2020, NEUROLOGY, V94, pE1749, DOI 10.1212/WNL.0000000000008981
   Hooper L, 2008, AM J CLIN NUTR, V88, P38, DOI 10.1093/ajcn/88.1.38
   HOTAMISLIGIL GS, 1993, SCIENCE, V259, P87, DOI 10.1126/science.7678183
   Imessaoudene A, 2016, J NUTR BIOCHEM, V29, P107, DOI 10.1016/j.jnutbio.2015.11.011
   Janssens PLHR, 2015, J NUTR, V145, P864, DOI 10.3945/jn.114.207829
   Joshi T, 2019, J CELL PHYSIOL, V234, P17212, DOI 10.1002/jcp.28528
   Keppler K, 2005, BIOORGAN MED CHEM, V13, P5195, DOI 10.1016/j.bmc.2005.05.003
   Larson AJ, 2012, ADV NUTR, V3, P39, DOI 10.3945/an.111.001271
   Lauby-Secretan B, 2016, NEW ENGL J MED, V375, P794, DOI 10.1056/NEJMsr1606602
   Laurin D, 2004, AM J EPIDEMIOL, V159, P959, DOI 10.1093/aje/kwh124
   Lee HC, 2006, RES MICROBIOL, V157, P876, DOI 10.1016/j.resmic.2006.07.004
   Manach C, 2005, AM J CLIN NUTR, V81, p230S, DOI 10.1093/ajcn/81.1.230S
   Manach C, 2004, FREE RADICAL RES, V38, P771, DOI 10.1080/10715760410001727858
   Sabogal-Guáqueta AM, 2015, NEUROPHARMACOLOGY, V93, P134, DOI 10.1016/j.neuropharm.2015.01.027
   Marques C, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-29744-5
   Marranzano M, 2018, INT J FOOD SCI NUTR, V69, P1020, DOI 10.1080/09637486.2018.1452900
   Marventano S, 2015, INT J FOOD SCI NUTR, V66, P611, DOI 10.3109/09637486.2015.1077790
   Massot-Cladera M, 2014, BRIT J NUTR, V112, P1944, DOI 10.1017/S0007114514003080
   Meng XF, 2002, CHEM RES TOXICOL, V15, P1042, DOI 10.1021/tx010184a
   Most J, 2014, INT J OBESITY, V38, P698, DOI 10.1038/ijo.2013.231
   Ng M., 2014, Lancet, V384, P766
   Ola MS, 2017, SAUDI J BIOL SCI, V24, P1186, DOI 10.1016/j.sjbs.2016.11.017
   Orhan IE, 2015, CURR MED CHEM, V22, P1004, DOI 10.2174/0929867322666141212122352
   Overman A, 2011, INT J OBESITY, V35, P1165, DOI 10.1038/ijo.2010.272
   Parkar SG, 2008, INT J FOOD MICROBIOL, V124, P295, DOI 10.1016/j.ijfoodmicro.2008.03.017
   Patel RV, 2018, EUR J MED CHEM, V155, P889, DOI 10.1016/j.ejmech.2018.06.053
   Patterson E, 2016, POSTGRAD MED J, V92, P286, DOI 10.1136/postgradmedj-2015-133285
   Petersson SD, 2016, ADV NUTR, V7, P889, DOI 10.3945/an.116.012138
   Pietta PG, 2000, J NAT PROD, V63, P1035, DOI 10.1021/np9904509
   Procházková D, 2011, FITOTERAPIA, V82, P513, DOI 10.1016/j.fitote.2011.01.018
   Rangel-Huerta OD, 2015, J NUTR, V145, P1808, DOI 10.3945/jn.115.213660
   Rios LY, 2003, AM J CLIN NUTR, V77, P912, DOI 10.1093/ajcn/77.4.912
   Rivera L, 2008, OBESITY, V16, P2081, DOI 10.1038/oby.2008.315
   Roopchand DE, 2015, DIABETES, V64, P2847, DOI 10.2337/db14-1916
   Root M, 2015, J MED FOOD, V18, P1327, DOI 10.1089/jmf.2015.0010
   Roowi S, 2009, MOL NUTR FOOD RES, V53, pS68, DOI 10.1002/mnfr.200800287
   Scalbert A, 2000, J NUTR, V130, p2073S, DOI 10.1093/jn/130.8.2073S
   Scholey AB, 2010, J PSYCHOPHARMACOL, V24, P1505, DOI 10.1177/0269881109106923
   Serafini M, 2002, BRIT J NUTR, V88, P615, DOI 10.1079/BJN2002722
   Serafini M, 2010, P NUTR SOC, V69, P273, DOI 10.1017/S002966511000162X
   Serban MC, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.115.002713
   Shi GJ, 2019, BIOMED PHARMACOTHER, V109, P1085, DOI 10.1016/j.biopha.2018.10.130
   Shishtar E, 2020, PUBLIC HEALTH NUTR, V23, P1576, DOI 10.1017/S136898001900394X
   Shishtar E, 2020, AM J CLIN NUTR, V112, P343, DOI 10.1093/ajcn/nqaa079
   Simioni Carolina, 2018, Oncotarget, V9, P17181, DOI 10.18632/oncotarget.24729
   Simons AL, 2005, J AGR FOOD CHEM, V53, P4258, DOI 10.1021/jf0500177
   Singh GM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0065174
   Terra X, 2011, J NUTR BIOCHEM, V22, P380, DOI 10.1016/j.jnutbio.2010.03.006
   Terra X, 2009, J NUTR BIOCHEM, V20, P210, DOI 10.1016/j.jnutbio.2008.02.005
   Tomás-Navarro M, 2014, J AGR FOOD CHEM, V62, P24, DOI 10.1021/jf4048989
   Turnbaugh PJ, 2009, NATURE, V457, P480, DOI 10.1038/nature07540
   Tzounis X, 2011, AM J CLIN NUTR, V93, P62, DOI 10.3945/ajcn.110.000075
   van Duynhoven J, 2011, P NATL ACAD SCI USA, V108, P4531, DOI 10.1073/pnas.1000098107
   Vazquez-Prieto MA, 2011, AM J HYPERTENS, V24, P234, DOI 10.1038/ajh.2010.214
   Visioli F, 2011, CRIT REV FOOD SCI, V51, P524, DOI 10.1080/10408391003698677
   Vitaglione P, 2007, J NUTR, V137, P2043, DOI 10.1093/jn/137.9.2043
   Whyte AR, 2015, NUTRITION, V31, P531, DOI 10.1016/j.nut.2014.09.013
   Wilkin TJ, 2004, J ROY SOC MED, V97, P511, DOI 10.1258/jrsm.97.11.511
   Williamson G, 2010, BRIT J NUTR, V104, pS48, DOI 10.1017/S0007114510003946
NR 91
TC 5
Z9 5
U1 1
U2 25
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8665
EI 1875-5305
J9 PROTEIN PEPTIDE LETT
JI Protein Pept. Lett.
PY 2021
VL 28
IS 7
BP 725
EP 734
DI 10.2174/0929866528666210127152359
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA TZ5PC
UT WOS:000684523300002
PM 33504293
DA 2025-06-11
ER

PT J
AU Teixeira, CJ
   Veras, K
   Carvalho, CRD
AF Teixeira, Caio Jordao
   Veras, Katherine
   de Oliveira Carvalho, Carla Roberta
TI Dehydroepiandrosterone on metabolism and the cardiovascular system in
   the postmenopausal period
SO JOURNAL OF MOLECULAR MEDICINE-JMM
LA English
DT Review
DE Dehydroepiandrosterone; Menopause; Adiposity; Insulin resistance;
   Metabolic syndrome; Cardiovascular disease
ID ELEVATED HEPATIC GLUCOSE-6-PHOSPHATASE; CAROTID-ARTERY DISTENSIBILITY;
   STIMULATED INSULIN-SECRETION; URINARY ALBUMIN EXCRETION;
   PROTEIN-KINASE-C; OXIDATIVE STRESS; GLUCOSE-UPTAKE; IN-VITRO; ORAL
   DEHYDROEPIANDROSTERONE; REPLACEMENT THERAPY
AB Dehydroepiandrosterone (DHEA), mostly present as its sulfated ester (DHEA-S), is an anabolic hormone that naturally declines with age. Furthermore, it is the most abundant androgen and estrogen precursor in humans. Low plasma levels of DHEA have been strongly associated with obesity, insulin resistance, dyslipidemia, and high blood pressure, increasing the risk of cardiovascular disease. In this respect, DHEA could be regarded as a promising agent against metabolic syndrome (MetS) in postmenopausal women, since several age-related metabolic diseases are reported during aging. There are plenty of experimental evidences showing beneficial effects after DHEA therapy on carbohydrate and lipid metabolism, as well as cardiovascular health. However, its potential as a therapeutic agent appears to attract controversy, due to the lack of effects on some symptoms related to MetS. In this review, we examine the available literature regarding the impact of DHEA therapy on adiposity, glucose metabolism, and the cardiovascular system in the postmenopausal period. Both clinical studies and in vitro and in vivo experimental models were selected, and where possible, the main cellular mechanisms involved in DHEA therapy were discussed.
C1 [Teixeira, Caio Jordao] Univ Estadual Campinas, Fac Med Sci, Dept Pharmacol, 105 Alexander Fleming St, BR-13083881 Campinas, SP, Brazil.
   [Teixeira, Caio Jordao; de Oliveira Carvalho, Carla Roberta] Univ Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, 1524 Prof Lineu Prestes Ave,ICB 1, BR-05508900 Sao Paulo, SP, Brazil.
   [Veras, Katherine] Univ Mogi das Cruzes, Dept Nutr, 200 Dr Candido XA Souza Ave, BR-08780911 Sao Paulo, SP, Brazil.
C3 Universidade Estadual de Campinas; Universidade de Sao Paulo;
   Universidade de Mogi das Cruzes
RP Carvalho, CRD (corresponding author), Univ Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, 1524 Prof Lineu Prestes Ave,ICB 1, BR-05508900 Sao Paulo, SP, Brazil.
EM croc@icb.usp.br
RI VERAS, KATHERINE/HTS-8114-2023; Carvalho, Carla/H-6476-2018; Jordao
   Teixeira, Caio/D-5685-2018
OI Veras, Katherine/0000-0003-2658-8618; Carvalho,
   Carla/0000-0001-5824-8656; Jordao Teixeira, Caio/0000-0002-4951-1130
FU Brazilian research agency: Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior (CAPES) [001]; Brazilian research agency: Fundacao de
   Amparo a Pesquisa do Estado de Sao Paulo [FAPESP-2012/14183-7];
   Brazilian research agency: Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico [CNPq-303543/2014-0]
FX This study was supported by grants from the Brazilian research agencies:
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
   (CAPES-Finance Code 001), Fundacao de Amparo a Pesquisa do Estado de Sao
   Paulo (FAPESP-2012/14183-7), and Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq-303543/2014-0).
CR ABADIE JM, 1993, DIABETES, V42, P662, DOI 10.2337/diabetes.42.5.662
   Adeva-Andany MM, 2016, BIOSCIENCE REP, V36, DOI 10.1042/BSR20160385
   Aguirre GA, 2016, J TRANSL MED, V14, DOI 10.1186/s12967-015-0762-z
   Almeida F.N., 2013, RES ENDOCRINOL, V2013, P1, DOI DOI 10.5171/2013.675769
   Anagnostis P, 2019, CURR VASC PHARMACOL, V17, P564, DOI 10.2174/1570161116666180709095348
   Aoki K, 1999, DIABETES, V48, P1579, DOI 10.2337/diabetes.48.8.1579
   Aoki K, 2004, LIFE SCI, V74, P3075, DOI 10.1016/j.lfs.2003.10.031
   Aoki K, 2000, ENDOCR J, V47, P799, DOI 10.1507/endocrj.47.799
   Aoki K, 2016, J STEROID BIOCHEM, V159, P110, DOI 10.1016/j.jsbmb.2016.03.011
   Apostolova G, 2005, AM J PHYSIOL-ENDOC M, V288, pE957, DOI 10.1152/ajpendo.00442.2004
   ARAD Y, 1989, ARTERIOSCLEROSIS, V9, P159, DOI 10.1161/01.ATV.9.2.159
   Araujo LCC, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-29044-y
   BARBAGALLO M, 1995, HYPERTENSION, V26, P1065, DOI 10.1161/01.HYP.26.6.1065
   BARRETTCONNOR E, 1995, CIRCULATION, V91, P1757, DOI 10.1161/01.CIR.91.6.1757
   BAULIEU EE, 1991, BIOL CELL, V71, P3, DOI 10.1016/0248-4900(91)90045-O
   Beaujean D, 2002, ENDOCRINOLOGY, V143, P1950, DOI 10.1210/en.143.5.1950
   Bernini GP, 1999, J CLIN ENDOCR METAB, V84, P2008, DOI 10.1210/jc.84.6.2008
   Bhuiyan MS, 2009, EXPERT OPIN THER TAR, V13, P1253, DOI 10.1517/14728220903264064
   Borgo MV, 2016, BRAZ J MED BIOL RES, V49, DOI [10.1590/1414-431X20154655, 10.1590/1414-431x20154655]
   Boura-Halfon S, 2009, AM J PHYSIOL-ENDOC M, V296, pE581, DOI 10.1152/ajpendo.90437.2008
   Boxer RS, 2010, AGE AGEING, V39, P451, DOI 10.1093/ageing/afq043
   Brahimaj A, 2017, DIABETOLOGIA, V60, P98, DOI 10.1007/s00125-016-4136-8
   Camilleri G, 2012, CLIMACTERIC, V15, P524, DOI 10.3109/13697137.2012.700743
   Campbell CSG, 2004, LIFE SCI, V76, P57, DOI 10.1016/j.lfs.2004.06.017
   Cappola AR, 2006, J GERONTOL A-BIOL, V61, P957, DOI 10.1093/gerona/61.9.957
   Carr MC, 2003, J CLIN ENDOCR METAB, V88, P2404, DOI 10.1210/jc.2003-030242
   Casson PR, 1998, FERTIL STERIL, V70, P107, DOI 10.1016/S0015-0282(98)00121-6
   Catalina F, 1999, P SOC EXP BIOL MED, V221, P326, DOI 10.1046/j.1525-1373.1999.d01-89.x
   Catalina F, 2001, EXP BIOL MED, V226, P208, DOI 10.1177/153537020122600308
   Cecconello AL, 2015, ENDOCRINE, V48, P985, DOI 10.1007/s12020-014-0396-6
   Cervellati C, 2016, CLIN CHEM LAB MED, V54, P739, DOI 10.1515/cclm-2015-0807
   Chen WC, 2016, INT J MED SCI, V13, P730, DOI 10.7150/ijms.16132
   Chen YM, 2018, INT J MED SCI, V15, P564, DOI 10.7150/ijms.23352
   Cheng HH, 2009, ACTA PHARMACOL SIN, V30, P42, DOI 10.1038/aps.2008.2
   Chlebowski RT, 2010, JAMA-J AM MED ASSOC, V304, P1684, DOI 10.1001/jama.2010.1500
   COLEMAN DL, 1982, DIABETES, V31, P830, DOI 10.2337/diabetes.31.9.830
   Côté I, 2014, BRIT J NUTR, V112, P1592, DOI 10.1017/S0007114514002517
   Cushman M, 2018, RES PRACT THROMB HAE, V2, P310, DOI 10.1002/rth2.12100
   Davis SR, 2011, J CLIN ENDOCR METAB, V96, P1642, DOI 10.1210/jc.2010-2888
   Davison SL, 2005, J CLIN ENDOCR METAB, V90, P3847, DOI 10.1210/jc.2005-0212
   DePergola G, 1996, INT J OBESITY, V20, P1105
   Dhatariya K, 2005, DIABETES, V54, P765, DOI 10.2337/diabetes.54.3.765
   Diamond P, 1996, J ENDOCRINOL, V150, pS43
   Dillon JS, 2000, DIABETES, V49, P2012, DOI 10.2337/diabetes.49.12.2012
   DiMonaco M, 1997, BRIT J CANCER, V75, P589, DOI 10.1038/bjc.1997.102
   Herrera MD, 2010, AGEING RES REV, V9, P142, DOI 10.1016/j.arr.2009.07.002
   Dunay GA, 2015, MENOPAUSE, V22, P773, DOI 10.1097/GME.0000000000000377
   EICH DM, 1993, CIRCULATION, V87, P261, DOI 10.1161/01.CIR.87.1.261
   Elraiyah T, 2014, J CLIN ENDOCR METAB, V99, P3536, DOI 10.1210/jc.2014-2261
   Emer E, 2016, HUM EXP TOXICOL, V35, P562, DOI 10.1177/0960327115595706
   Fang ZS, 2016, BBA-MOL CELL RES, V1863, P2245, DOI 10.1016/j.bbamcr.2016.05.016
   Fujioka K, 2012, AM J PHYSIOL-ENDOC M, V302, pE694, DOI 10.1152/ajpendo.00112.2011
   Fukui M, 2004, DIABETES CARE, V27, P2893, DOI 10.2337/diacare.27.12.2893
   Fukui M, 2007, METABOLISM, V56, P1167, DOI 10.1016/j.metabol.2007.04.011
   Fukui M, 2007, DIABETES CARE, V30, P1886, DOI 10.2337/dc06-2325
   Camporez JPG, 2011, J PHYSIOL-LONDON, V589, P2585, DOI 10.1113/jphysiol.2011.206078
   GANSLER TS, 1985, P SOC EXP BIOL MED, V180, P155
   Gill SK, 2015, MED CLIN N AM, V99, P535, DOI 10.1016/j.mcna.2015.01.007
   Giroix MH, 1997, BIOCHEM MOL MED, V61, P72, DOI 10.1006/bmme.1997.2581
   Godia EC, 2007, J ULTRAS MED, V26, P1157, DOI 10.7863/jum.2007.26.9.1157
   Goel RM, 2011, CURR OPIN ENDOCRINOL, V18, P171, DOI 10.1097/MED.0b013e3283461818
   Gómez-Santos C, 2012, CLIN ENDOCRINOL, V77, P548, DOI 10.1111/j.1365-2265.2011.04306.x
   GORDON GB, 1988, J CLIN INVEST, V82, P712, DOI 10.1172/JCI113652
   Gorres BK, 2011, J APPL PHYSIOL, V110, P1046, DOI 10.1152/japplphysiol.00541.2010
   Grasfeder LL, 2009, MOL ENDOCRINOL, V23, P1171, DOI 10.1210/me.2009-0024
   Greenberg CC, 2006, AM J PHYSIOL-ENDOC M, V291, pE1, DOI 10.1152/ajpendo.00652.2005
   Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
   Hakkak R, 2017, SCI PHARM, V85, DOI 10.3390/scipharm85010013
   Hallajzadeh J, 2018, MENOPAUSE, V25, P1155, DOI 10.1097/GME.0000000000001136
   Han DH, 1998, J GERONTOL A-BIOL, V53, pB19, DOI 10.1093/gerona/53A.1.B19
   Hansen PA, 1997, AM J PHYSIOL-REG I, V273, pR1704, DOI 10.1152/ajpregu.1997.273.5.R1704
   Harrington LB, 2017, J THROMB HAEMOST, V15, P80, DOI 10.1111/jth.13554
   Hayashi T, 2000, ARTERIOSCL THROM VAS, V20, P782, DOI 10.1161/01.ATV.20.3.782
   HAYASHI T, 1995, J CARDIOVASC PHARM, V26, P792, DOI 10.1097/00005344-199511000-00017
   HERRINGTON DM, 1990, J AM COLL CARDIOL, V16, P862
   Hoefel AL, 2018, CAN J PHYSIOL PHARM, V96, P1069, DOI 10.1139/cjpp-2018-0159
   Hotamisligil GS, 2017, NATURE, V542, P177, DOI 10.1038/nature21363
   Huang BY, 2000, CARDIOVASC RES, V46, P442, DOI 10.1016/S0008-6363(00)00017-1
   Iorga A, 2017, BIOL SEX DIFFER, V8, DOI 10.1186/s13293-017-0152-8
   Ishizuka T, 1999, AM J PHYSIOL-ENDOC M, V276, pE196, DOI 10.1152/ajpendo.1999.276.1.E196
   Ishizuka T, 2007, ACTA DIABETOL, V44, P219, DOI 10.1007/s00592-007-0009-4
   Jahn MP, 2010, J STEROID BIOCHEM, V120, P38, DOI 10.1016/j.jsbmb.2010.03.015
   Jankowski CM, 2011, CLIN ENDOCRINOL, V75, P456, DOI 10.1111/j.1365-2265.2011.04073.x
   Jiménez MC, 2013, STROKE, V44, P1785, DOI 10.1161/STROKEAHA.111.000485
   Kajita K, 2000, BIOCHEM BIOPH RES CO, V277, P361, DOI 10.1006/bbrc.2000.3677
   Kajita K, 2003, ENDOCRINOLOGY, V144, P253, DOI 10.1210/en.2002-220039
   Kanazawa I, 2008, ENDOCR J, V55, P667, DOI 10.1507/endocrj.K07E-130
   Kang J, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0159077
   Karbowska J, 2005, BIOCHEM PHARMACOL, V70, P249, DOI 10.1016/j.bcp.2005.04.022
   Karbowska J, 2013, HORM MOL BIOL CLIN I, V14, P65, DOI 10.1515/hmbci-2013-0009
   Karbowska J, 2012, STEROIDS, V77, P1359, DOI 10.1016/j.steroids.2012.08.002
   Kimura M, 1998, ENDOCRINOLOGY, V139, P3249, DOI 10.1210/en.139.7.3249
   Klair JS, 2016, HEPATOLOGY, V64, P85, DOI 10.1002/hep.28514
   Labrie F, 2013, CLIMACTERIC, V16, P205, DOI 10.3109/13697137.2012.733983
   Lalevée N, 2005, CARDIOVASC RES, V67, P216, DOI 10.1016/j.cardiores.2005.05.009
   Laliberté F, 2018, MENOPAUSE, V25, P1297, DOI 10.1097/GME.0000000000001232
   Lasco A, 2001, EUR J ENDOCRINOL, V145, P457, DOI 10.1530/eje.0.1450457
   Laychock SG, 1998, BIOCHEM PHARMACOL, V55, P1453, DOI 10.1016/S0006-2952(97)00666-7
   Laychock SG, 1996, ENDOCRINOLOGY, V137, P3375, DOI 10.1210/en.137.8.3375
   Lea-Currie YR, 1998, BIOCHEM BIOPH RES CO, V248, P497, DOI 10.1006/bbrc.1998.8996
   Lefebvre P, 2006, J CLIN INVEST, V116, P571, DOI 10.1172/JCI27989
   Legeza B, 2017, NUTRIENTS, V9, DOI 10.3390/nu9050426
   Liu DM, 2004, STEROIDS, V69, P279, DOI 10.1016/j.steroids.2004.02.004
   Liu DM, 2006, STEROIDS, V71, P691, DOI 10.1016/j.steroids.2006.04.001
   Liu HK, 2006, BIOSCIENCE REP, V26, P31, DOI 10.1007/s10540-006-9001-4
   Lizcano F, 2014, BIOMED RES INT, V2014, DOI 10.1155/2014/757461
   London GM, 2002, AM J HYPERTENS, V15, P754, DOI 10.1016/S0895-7061(02)02966-7
   Ma JL, 2018, BIOCHEM BIOPH RES CO, V500, P671, DOI 10.1016/j.bbrc.2018.04.134
   Mannic T, 2013, ENDOCRINOLOGY, V154, P1271, DOI 10.1210/en.2012-1784
   Mascarenhas-Melo F, 2013, DIS MARKERS, V2013, P85, DOI 10.1155/2013/724706
   Mayer D, 2004, INT J ONCOL, V25, P1021
   Mayer D, 1996, INT J ONCOL, V8, P1069
   McCrohon JA, 2000, CIRCULATION, V101, P224, DOI 10.1161/01.CIR.101.3.224
   MCINTOSH MK, 1991, J NUTR, V121, P2037, DOI 10.1093/jn/121.12.2037
   McNelis JC, 2013, AM J PHYSIOL-ENDOC M, V305, pE1134, DOI 10.1152/ajpendo.00314.2012
   Medina MC, 2006, FEBS LETT, V580, P285, DOI 10.1016/j.febslet.2005.12.014
   MORTOLA JF, 1990, J CLIN ENDOCR METAB, V71, P696, DOI 10.1210/jcem-71-3-696
   Munhoz AC, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0158166
   Nair KS, 2006, NEW ENGL J MED, V355, P1647, DOI 10.1056/NEJMoa054629
   Navar D, 2006, NUTR NEUROSCI, V9, P225, DOI 10.1080/10284150601090102
   NESTLER JE, 1988, J CLIN ENDOCR METAB, V66, P57, DOI 10.1210/jcem-66-1-57
   Ng MKC, 2003, J AM COLL CARDIOL, V42, P1967, DOI 10.1016/j.jacc.2003.07.024
   ORENTREICH N, 1984, J CLIN ENDOCR METAB, V59, P551, DOI 10.1210/jcem-59-3-551
   Page JH, 2008, CLIN CHEM, V54, P1190, DOI 10.1373/clinchem.2007.099291
   Palombo C, 2016, VASC PHARMACOL, V77, P1, DOI 10.1016/j.vph.2015.11.083
   Panjari M, 2010, MATURITAS, V66, P172, DOI 10.1016/j.maturitas.2009.12.017
   Panjari M, 2009, MATURITAS, V63, P240, DOI 10.1016/j.maturitas.2009.03.020
   de Heredia FP, 2007, BRIT J NUTR, V97, P464, DOI 10.1017/S0007114507332546
   Perrini S, 2004, DIABETES, V53, P41, DOI 10.2337/diabetes.53.1.41
   Polotsky HN, 2010, SEMIN REPROD MED, V28, P426, DOI 10.1055/s-0030-1262902
   Porter J, 2005, AM J PHYSIOL-REG I, V288, pR928, DOI 10.1152/ajpregu.00290.2003
   PORTER JR, 1995, INT J OBESITY, V19, P480
   Prough RA, 2016, J MOL ENDOCRINOL, V56, pR139, DOI 10.1530/JME-16-0013
   Rainey WE, 2002, TRENDS ENDOCRIN MET, V13, P234, DOI 10.1016/S1043-2760(02)00609-4
   Rangel-Zuñiga OA, 2017, MECH AGEING DEV, V164, P41, DOI 10.1016/j.mad.2017.04.002
   Rebelato E, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0024507
   Rice SPL, 2010, MOL CELL ENDOCRINOL, V320, P51, DOI 10.1016/j.mce.2010.02.017
   Roest M, 2001, CIRCULATION, V103, P3057, DOI 10.1161/hc2501.091353
   Rosamond W, 2008, CIRCULATION, V117, pE25, DOI 10.1161/CIRCULATIONAHA.107.187998
   Rossier MF, 2008, HYPERTENSION, V52, P721, DOI 10.1161/HYPERTENSIONAHA.108.114223
   Ryu JW, 2003, BIOCHEM BIOPH RES CO, V303, P726, DOI 10.1016/S0006-291X(03)00409-1
   Safiulina D, 2006, TOXICOL SCI, V93, P348, DOI 10.1093/toxsci/kfl064
   Sánchez J, 2008, J NUTR BIOCHEM, V19, P809, DOI 10.1016/j.jnutbio.2007.10.005
   Santen RJ, 2010, J CLIN ENDOCR METAB, V95, pS7, DOI 10.1210/jc.2009-2509
   Sarrel P M, 1999, Cardiologia, V44 Suppl 1, P515
   Sato K, 2009, ACTA PHYSIOL, V197, P217, DOI 10.1111/j.1748-1716.2009.02011.x
   Sato K, 2008, AM J PHYSIOL-ENDOC M, V294, pE961, DOI 10.1152/ajpendo.00678.2007
   Sato K, 2018, VITAM HORM, V108, P205, DOI 10.1016/bs.vh.2018.03.002
   Sato K, 2012, NUTR METAB, V9, DOI 10.1186/1743-7075-9-47
   Sato K, 2011, AM J PHYSIOL-ENDOC M, V301, pE274, DOI 10.1152/ajpendo.00564.2010
   Shook Robin P, 2014, Eur Endocrinol, V10, P136, DOI 10.17925/EE.2014.10.02.136
   Shufelt C, 2016, MENOPAUSE, V23, P150, DOI 10.1097/GME.0000000000000510
   Shufelt C, 2010, J CLIN ENDOCR METAB, V95, P4985, DOI 10.1210/jc.2010-0143
   Spégel P, 2013, BIOCHEM J, V450, P595, DOI 10.1042/BJ20121349
   Stefanska A, 2015, ADV CLIN CHEM, V72, P1, DOI 10.1016/bs.acc.2015.07.001
   Strain WD, 2005, DIABETES, V54, P1816, DOI 10.2337/diabetes.54.6.1816
   Subramanya V, 2018, MATURITAS, V108, P37, DOI 10.1016/j.maturitas.2017.11.006
   Svec F, 1997, PSYCHONEUROENDOCRINO, V22, pS57, DOI 10.1016/S0306-4530(97)00004-8
   Tagashira H, 2011, MENOPAUSE, V18, P1317, DOI 10.1097/gme.0b013e31821f915b
   Tagawa N, 2011, STEROIDS, V76, P1546, DOI 10.1016/j.steroids.2011.09.005
   TAGLIAFERRO AR, 1995, AM J PHYSIOL-REG I, V268, pR1374, DOI 10.1152/ajpregu.1995.268.6.R1374
   TAGLIAFERRO AR, 1986, J NUTR, V116, P1977, DOI 10.1093/jn/116.10.1977
   Tchernof A, 2004, EUR J ENDOCRINOL, V151, P1, DOI 10.1530/eje.0.1510001
   Teixeira CJ, 2018, LIFE SCI, V202, P110, DOI 10.1016/j.lfs.2018.03.052
   Usman M, 2018, DIABETES RES CLIN PR, V146, P76, DOI 10.1016/j.diabres.2018.10.002
   Van Sinderen ML, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0136143
   Veras K, 2014, FEBS OPEN BIO, V4, P141, DOI 10.1016/j.fob.2014.01.005
   Jacob MHVM, 2011, J STEROID BIOCHEM, V127, P331, DOI 10.1016/j.jsbmb.2011.07.007
   Jacob MHVM, 2009, STEROIDS, V74, P1045, DOI 10.1016/j.steroids.2009.08.005
   Villareal DT, 2004, JAMA-J AM MED ASSOC, V292, P2243, DOI 10.1001/jama.292.18.2243
   Wang L, 2011, ATHEROSCLEROSIS, V214, P47, DOI 10.1016/j.atherosclerosis.2010.07.043
   Wang XY, 2015, J STEROID BIOCHEM, V153, P35, DOI 10.1016/j.jsbmb.2015.07.008
   Wassmann S, 2001, CIRCULATION, V103, P435
   WEINDRUCH R, 1984, EXP GERONTOL, V19, P297, DOI 10.1016/0531-5565(84)90002-0
   Weiss EP, 2012, AGING CELL, V11, P876, DOI 10.1111/j.1474-9726.2012.00852.x
   Weiss EP, 2011, AGING-US, V3, P533, DOI 10.18632/aging.100327
   WRIGHT BE, 1993, PHYSIOL BEHAV, V53, P39, DOI 10.1016/0031-9384(93)90008-4
   WRIGHT BE, 1995, INT J OBESITY, V19, P887
   YAMADA J, 1991, BIOCHIM BIOPHYS ACTA, V1092, P233, DOI 10.1016/0167-4889(91)90162-Q
   Yamaguchi Y, 1998, CLIN ENDOCRINOL, V49, P377, DOI 10.1046/j.1365-2265.1998.00533.x
   Yamashita R, 2005, ENDOCR J, V52, P727, DOI 10.1507/endocrj.52.727
   Yin FJ, 2015, GENET MOL RES, V14, P11300, DOI 10.4238/2015.September.22.24
   Yoshida S, 2003, STEROIDS, V68, P73, DOI 10.1016/S0039-128X(02)00117-4
   Yoshida S, 2010, ATHEROSCLEROSIS, V212, P310, DOI 10.1016/j.atherosclerosis.2010.05.011
   Yue J, 2013, BIOCHEM BIOPH RES CO, V440, P756, DOI 10.1016/j.bbrc.2013.10.002
   Zhang ZY, 2010, FASEB J, V24, P1497, DOI 10.1096/fj.09-136572
   Zhao D, 2018, J AM COLL CARDIOL, V71, P2555, DOI 10.1016/j.jacc.2018.01.083
   Zhou YQ, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0124511
NR 188
TC 20
Z9 20
U1 0
U2 10
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0946-2716
EI 1432-1440
J9 J MOL MED
JI J. Mol. Med.
PD JAN
PY 2020
VL 98
IS 1
BP 39
EP 57
DI 10.1007/s00109-019-01842-5
EA NOV 2019
PG 19
WC Genetics & Heredity; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Research & Experimental Medicine
GA KJ2BH
UT WOS:000495980700001
PM 31713639
DA 2025-06-11
ER

PT J
AU Kheirbakhsh, R
   Haddadi, M
   Muhammadnejad, A
   Abdollahi, A
   Shahi, F
   Amanpour-Gharaei, B
   Abrahim-Habibi, A
   Barati, T
   Amanpour, S
AF Kheirbakhsh, Raheleh
   Haddadi, Mahnaz
   Muhammadnejad, Ahad
   Abdollahi, Alireza
   Shahi, Farshad
   Amanpour-Gharaei, Behzad
   Abrahim-Habibi, Azadeh
   Barati, Tahereh
   Amanpour, Saeid
TI Long-term behavioral, histological, biochemical and hematological
   evaluations of amyloid beta-induced Alzheimer's disease in rat
SO ACTA NEUROBIOLOGIAE EXPERIMENTALIS
LA English
DT Article
DE Alzheimer's disease; amyloid beta; animal model; long-term evaluation
ID MEMORY IMPAIRMENT; OXIDATIVE STRESS; LIPID-PEROXIDATION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; BRAIN; RISK; DIAGNOSIS; PEPTIDE;
   GLUCOSE
AB Alzheimer's disease (AD) is a mental impairment and neural degeneration which causes progressive loss of memory and cognitive functions. This age-dependent illness is associated with extracellular amyloid plaques accumulation and twisted neurofibrillary tangles. Amyloid plaques are experimentally generated in animal models in order to investigate the disease process. In this study, we followed a rat model of AD for over a year. Wistar rats were divided randomly into two groups as control group (surgery without injection An), and experimental group (two-sided intrahippocampal amyloid-beta injection into hippocampus). From each group, three animals were investigated 42 days after injection, and the remaining four animals were studied after one year. All animals were tested for learning abilities and memory. Finally, samples from blood, brain, heart, kidney, liver, colon and spleen were examined. In the experimental group, the size of amyloid plaques were increased significantly after one year and learning abilities and memory were concomitantly decreased. Onsets of various other conditions such as liver and kidney disorders, diabetes, and metabolic syndrome were observed, which indicates that the animals may be prone to cardiovascular disorders and ischemia.
C1 [Kheirbakhsh, Raheleh; Muhammadnejad, Ahad; Barati, Tahereh; Amanpour, Saeid] Univ Tehran Med Sci, Canc Res Inst Iran, Canc Biol Res Ctr, Tehran, Iran.
   [Haddadi, Mahnaz] Univ Tehran Med Sci, Vali E Asr Reprod Hlth Res Ctr, Tehran, Iran.
   [Abdollahi, Alireza] Univ Tehran Med Sci, Sch Med, Dept Pathol, Imam Khomeini Hosp Complex, Tehran, Iran.
   [Shahi, Farshad] Islamic Azad Univ, Tehran Med Branch, Tehran, Iran.
   [Amanpour-Gharaei, Behzad] Univ Tehran Med Sci, Res Ctr Mol & Cellular imaging, Neuroimaging & Anal Grp, Tehran, Iran.
   [Amanpour-Gharaei, Behzad] Ruhr Univ, Int Grad Sch Neurosci, Bochum, Germany.
   [Abrahim-Habibi, Azadeh] Univ Tehran Med Sci, Endocrinol & Metab Mol Cellular Sci Inst, Biosensor Res Ctr, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences; Islamic Azad
   University; Tehran University of Medical Sciences; Ruhr University
   Bochum; Tehran University of Medical Sciences
RP Amanpour, S (corresponding author), Univ Tehran Med Sci, Canc Res Inst Iran, Canc Biol Res Ctr, Tehran, Iran.
EM Amanpour_s@tums.ac.ir
RI Abdollahi, Mohammad/B-9232-2008; amanpour, saeid/AAR-2800-2020; Shahi,
   Farshad/AAI-2360-2021
OI Shahi, Farshad/0000-0002-4425-0189; amanpour, saeid/0000-0002-0395-418X
CR Afshari AT, 2007, FOOD CHEM, V101, P148, DOI 10.1016/j.foodchem.2006.01.013
   Alzheimer's Association, 2010, Alzheimers Dement, V6, P158, DOI 10.1016/j.jalz.2010.01.009
   [Anonymous], INT J ALZHEIMERS DIS
   [Anonymous], 2004, MOUSE BRAIN STEREOTA
   [Anonymous], RJMS
   [Anonymous], SANG THROMB VAISS
   Baker LD, 2011, ARCH NEUROL-CHICAGO, V68, P51, DOI 10.1001/archneurol.2010.225
   Calabrese V, 2000, NEUROCHEM RES, V25, P1315, DOI 10.1023/A:1007604414773
   Ceccom J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043105
   Choi HK, 2007, ARTHRIT RHEUM-ARTHR, V57, P109, DOI 10.1002/art.22466
   Choi JG, 2011, NEUROBIOL LEARN MEM, V96, P306, DOI 10.1016/j.nlm.2011.06.004
   Clearfield M, 2014, CURR ATHEROSCLER REP, V16, DOI 10.1007/s11883-013-0380-2
   CLEARY J, 1995, BRAIN RES, V682, P69, DOI 10.1016/0006-8993(95)00323-I
   Davies Peter, 2009, Dialogues Clin Neurosci, V11, P159
   Delgado JY, 2005, NEUROPHARMACOLOGY, V48, P936, DOI 10.1016/j.neuropharm.2005.01.008
   Dietrich P, 2014, BEST PRACT RES CL GA, V28, P637, DOI 10.1016/j.bpg.2014.07.008
   Dufour DR, 2000, CLIN CHEM, V46, P2027
   Everss E, 1998, PSICOTHEMA, V10, P387
   Ferenci P, 2003, LIVER INT, V23, P139, DOI 10.1034/j.1600-0676.2003.00824.x
   Fitzpatrick AL, 2009, ARCH NEUROL-CHICAGO, V66, P336, DOI 10.1001/archneurol.2008.582
   Frozza RL, 2009, NEUROCHEM RES, V34, P295, DOI 10.1007/s11064-008-9776-8
   Fujita K, 2013, NEUROCHEM RES, V38, P461, DOI 10.1007/s11064-012-0952-5
   Gandy S, 2005, J CLIN INVEST, V115, P1121, DOI 10.1172/JCI200525100
   Ghaznavi R, 2005, J NEPHROL, V18, P548
   Giboney PT, 2005, AM FAM PHYSICIAN, V71, P1105
   Goryacheva AV, 2010, NITRIC OXIDE-BIOL CH, V23, P289, DOI 10.1016/j.niox.2010.08.005
   Hamel E, 2004, PROG BRAIN RES, V145, P171, DOI 10.1016/S0079-6123(02)45012-7
   HARDY J, 1991, TRENDS PHARMACOL SCI, V12, P383, DOI 10.1016/0165-6147(91)90609-V
   Hoyer S, 2000, ANN NY ACAD SCI, V920, P256
   Iadecola C, 2004, NAT REV NEUROSCI, V5, P347, DOI 10.1038/nrn1387
   Janson J, 2004, DIABETES, V53, P474, DOI 10.2337/diabetes.53.2.474
   Jhoo JH, 2004, BEHAV BRAIN RES, V155, P185, DOI 10.1016/j.bbr.2004.04.012
   Karim S. M. F., 2015, DELTA MED COLL J, V3, P13, DOI [10.3329/dmcj.v3i1.22234, DOI 10.3329/DMCJ.V3I1.22234]
   Kheirbakhsh R, 2015, NEUROL SCI, V36, P1411, DOI 10.1007/s10072-015-2169-2
   Kota N, 2008, FOOD CHEM, V106, P991, DOI 10.1016/j.foodchem.2007.07.073
   Krones E, 2015, HEPATOLOGY, V62, P981, DOI 10.1002/hep.27622
   Lehmann J, 2004, CANCER, V101, P1552, DOI 10.1002/cncr.20549
   Limón D, 2012, EUR J PHARMACOL, V685, P74, DOI 10.1016/j.ejphar.2012.04.020
   Lu P, 2009, BRIT J PHARMACOL, V157, P1270, DOI 10.1111/j.1476-5381.2009.00295.x
   Lucyk SN, 2015, CLIN TOXICOL, V53, P786, DOI 10.3109/15563650.2015.1045980
   Lupien SB, 2003, J NEUROSCI RES, V74, P512, DOI 10.1002/jnr.10791
   Magenta A, 2013, INT J MOL SCI, V14, P17319, DOI 10.3390/ijms140917319
   Morris JK, 2014, BBA-MOL BASIS DIS, V1842, P1340, DOI 10.1016/j.bbadis.2014.04.012
   Nordestgaard BG, 2014, LANCET, V384, P626, DOI 10.1016/S0140-6736(14)61177-6
   O'Connell KM, 2013, BIOL RES NURS, V15, P253, DOI 10.1177/1099800411431823
   Oorts M, 2016, TOXICOL IN VITRO, V34, P179, DOI 10.1016/j.tiv.2016.03.008
   Parapid B, 2014, HELL J CARDIOL, V55, P92
   Petrella JR, 2003, RADIOLOGY, V226, P315, DOI 10.1148/radiol.2262011600
   POLVIKOSKI T, 1995, NEW ENGL J MED, V333, P1242, DOI 10.1056/NEJM199511093331902
   Pratt DS, 2000, NEW ENGL J MED, V342, P1266, DOI 10.1056/NEJM200004273421707
   Rafacho A, 2014, J ENDOCRINOL, V223, pR49, DOI 10.1530/JOE-14-0373
   Raurich JM, 2015, AM SURGEON, V81, P1209
   Selkoe DJ, 2016, EMBO MOL MED, V8, P595, DOI 10.15252/emmm.201606210
   Shi X, 2011, NEUROSCI LETT, V500, P87, DOI 10.1016/j.neulet.2011.06.009
   Sima AAF, 2005, DIABETES, V54, P1497, DOI 10.2337/diabetes.54.5.1497
   Stanga S, 2016, FASEB J, V30, P1696, DOI 10.1096/fj.15-278739
   Sultana R, 2006, ANTIOXID REDOX SIGN, V8, P2021, DOI 10.1089/ars.2006.8.2021
   Ting K. K., 2007, K TAKAI, V1304, P384, DOI [10.1016/j.ics.2007.07.010, DOI 10.1016/J.ICS.2007.07.010]
   Tönnies E, 2017, J ALZHEIMERS DIS, V57, P1105, DOI 10.3233/JAD-161088
   URBAN IJA, 1995, BEHAV BRAIN RES, V68, P173, DOI 10.1016/0166-4328(94)00172-C
   Vassar R, 1999, SCIENCE, V286, P735, DOI 10.1126/science.286.5440.735
   WENK GL, 1989, PSYCHOPHARMACOLOGY, V99, P431, DOI 10.1007/BF00589888
   Yaghmaei P, 2013, ARCH ITAL BIOL, V151, P106, DOI 10.4449/aib.v151i3.1479
   Yamaoka M, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0112813
   Yan RQ, 2014, LANCET NEUROL, V13, P319, DOI 10.1016/S1474-4422(13)70276-X
NR 65
TC 7
Z9 7
U1 0
U2 9
PU NENCKI INST EXPERIMENTAL BIOLOGY
PI WARSAW
PA UL PASTEURA 3, 02-093 WARSAW, POLAND
SN 0065-1400
EI 1689-0035
J9 ACTA NEUROBIOL EXP
JI Acta Neurobiol. Exp.
PY 2018
VL 78
IS 1
BP 51
EP 59
DI 10.21307/ane-2018-004
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GF4IH
UT WOS:000431925900006
PM 29694341
OA gold
DA 2025-06-11
ER

PT J
AU Talbot, S
   Dias, JP
   El Midaoui, A
   Couture, R
AF Talbot, Sebastien
   Dias, Jenny Pena
   El Midaoui, Adil
   Couture, Rejean
TI Beneficial effects of kinin B1 receptor antagonism on plasma fatty acid
   alterations and obesity in Zucker diabetic fatty rats
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE fatty acids; kinin B1 receptor; metabolic syndrome; obesity; SSR240612;
   type 2 diabetes; Zucker diabetic fatty rat
ID INSULIN-RESISTANT RATS; ALPHA-LIPOIC ACID; NERVE BLOOD-FLOW; OXIDATIVE
   STRESS; B-1 RECEPTOR; SENSORY ABNORMALITIES; NOCICEPTIVE BEHAVIOR;
   MODEL; BRADYKININ; MELLITUS
AB Kinins are the endogenous ligands of the constitutive B2 receptor (B2R) and the inducible B1 receptor (B1R). Whereas B2R prevents insulin resistance, B1R is involved in insulin resistance and metabolic syndrome. However, the contribution of B1R in type 2 diabetes associated with obesity remains uncertain. The aim of the present study was to examine the impact of 1-week treatment with a selective B1R antagonist (SSR240612, 10 mg/kg per day, by gavage) on hyperglycemia, hyperinsulinemia, leptinemia, body mass gain, and abnormal plasma fatty acids in obese Zucker diabetic fatty (ZDF) rats. Treatment with SSR240612 abolished the body mass gain and reduced polyphagia, polydipsia, and plasma fatty acid alterations in ZDF rats without affecting hyperglycemia, hyperinsulinemia, and hyperleptinemia. The present study suggests that the upregulated B1R plays a role in body mass gain and circulating fatty acid alterations in ZDF rats. However, mechanisms other than B1R induction would be implicated in glucose metabolism disorder in ZDF rats, based on the finding that SSR240612 did not reverse hyperglycemia and hyperinsulinemia.
C1 [Talbot, Sebastien; Dias, Jenny Pena; El Midaoui, Adil; Couture, Rejean] Univ Montreal, Fac Med, Dept Mol & Integrat Physiol, Stn City Ctr, POB 6128, Montreal, PQ H3C 3J7, Canada.
C3 Universite de Montreal
RP Couture, R (corresponding author), Univ Montreal, Fac Med, Dept Mol & Integrat Physiol, Stn City Ctr, POB 6128, Montreal, PQ H3C 3J7, Canada.
EM rejean.couture@umontreal.ca
OI Talbot, Sebastien/0000-0001-9932-7174
FU Canadian Institutes of Health Research (CIHR) [MOP-119329]; CIHR
FX This work was supported by a Grant-in-Aid from the Canadian Institutes
   of Health Research (CIHR) (MOP-119329) to RC. ST and JPD were recipients
   of Studentship Awards from the CIHR (Frederick Banting and Charles Best
   Canada Graduate Scholarships Doctoral Award). We are most grateful to
   Dr. Emile Levy's laboratory (Department of Nutrition, Ste-Justine
   Research Center, Universite de Montreal) for the measurement of plasma
   fatty acids and to Jacques Senecal for his technical assistance.
CR Barros CC, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0040573
   Blaes N, 2013, EXPERT OPIN THER TAR, V17, P1145, DOI 10.1517/14728222.2013.827664
   CAMERON NE, 1994, ACTA DIABETOL, V31, P220, DOI 10.1007/BF00571955
   Chen L, 2012, NAT REV ENDOCRINOL, V8, P228, DOI 10.1038/nrendo.2011.183
   Couture R, 2004, EUR J PHARMACOL, V500, P467, DOI 10.1016/j.ejphar.2004.07.045
   Couture R, 2014, CURR VASC PHARMACOL, V12, P223, DOI 10.2174/1570161112666140226121627
   Dias JP, 2012, DIABETES OBES METAB, V14, P244, DOI 10.1111/j.1463-1326.2011.01521.x
   Dias JP, 2015, PEPTIDES, V69, P118, DOI 10.1016/j.peptides.2015.04.022
   Dias JP, 2012, J CARDIOVASC PHARM, V60, P61, DOI 10.1097/FJC.0b013e3182576277
   Dias JP, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0012622
   Duka I, 2001, HYPERTENSION, V38, P1355, DOI 10.1161/hy1201.096574
   El Midaoui A, 2015, J DIABETES METAB, V6, DOI 10.4172/2155-6156.1000556
   El Midaoui A, 2011, CAN J PHYSIOL PHARM, V89, P743, DOI [10.1139/Y11-072, 10.1139/y11-072]
   Fonseca RG, 2013, J MOL MED, V91, P851, DOI 10.1007/s00109-013-1004-6
   Fukuchi S, 2004, EXP BIOL MED, V229, P486, DOI 10.1177/153537020422900606
   GIUGLIANO D, 1995, METABOLISM, V44, P363, DOI 10.1016/0026-0495(95)90167-1
   Gougat J, 2004, J PHARMACOL EXP THER, V309, P661, DOI 10.1124/jpet.103.059527
   Guariguata L, 2014, DIABETES RES CLIN PR, V103, P137, DOI 10.1016/j.diabres.2013.11.002
   Henriksen EJ, 1998, AM J PHYSIOL-REG I, V275, pR40, DOI 10.1152/ajpregu.1998.275.1.R40
   Ismael MA, 2008, EUR J PHARMACOL, V589, P66, DOI 10.1016/j.ejphar.2008.05.006
   Jaffa MA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0044714
   LEPAGE G, 1989, J LIPID RES, V30, P1483
   LEPAGE G, 1986, J LIPID RES, V27, P114
   Lungu C, 2007, NEUROPEPTIDES, V41, P375, DOI 10.1016/j.npep.2007.09.005
   Morais RL, 2015, DIABET METAB SYND OB, V8, P399, DOI 10.2147/DMSO.S87635
   Mori MA, 2008, DIABETES, V57, P1491, DOI 10.2337/db07-1508
   NAGAMATSU M, 1995, DIABETES CARE, V18, P1160, DOI 10.2337/diacare.18.8.1160
   Packer L, 2001, NUTRITION, V17, P888, DOI 10.1016/S0899-9007(01)00658-X
   Panchal SK, 2011, J BIOMED BIOTECHNOL, DOI 10.1155/2011/351982
   Park S, 2014, CURR MED CHEM, V21, P3636, DOI 10.2174/0929867321666140706141806
   Phillips MS, 1996, NAT GENET, V13, P18, DOI 10.1038/ng0596-18
   Piercy V, 1999, J DIABETES COMPLICAT, V13, P163, DOI 10.1016/S1056-8727(99)00034-3
   Regoli D, 2015, VASC PHARMACOL, V64, P1, DOI 10.1016/j.vph.2014.12.003
   Reis FCG, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0134844
   Rivera L, 2009, BIOCHEM PHARMACOL, V77, P1053, DOI 10.1016/j.bcp.2008.11.027
   Rodrigues ES, 2009, BIOL CHEM, V390, P907, DOI 10.1515/BC.2009.081
   Sabatini RA, 2008, HYPERTENSION, V51, P689, DOI 10.1161/HYPERTENSIONAHA.107.091181
   Schäfer S, 2004, BRIT J PHARMACOL, V143, P27, DOI 10.1038/sj.bjp.0705884
   Tomassoni D, 2013, NEUROSCI LETT, V543, P136, DOI 10.1016/j.neulet.2013.03.025
   Vincent AM, 2004, DIABETES, V53, P726, DOI 10.2337/diabetes.53.3.726
NR 40
TC 13
Z9 13
U1 0
U2 5
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD JUL
PY 2016
VL 94
IS 7
BP 752
EP 757
DI 10.1139/cjpp-2016-0063
PG 6
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA DQ0YG
UT WOS:000378927100010
PM 27172260
DA 2025-06-11
ER

PT J
AU Bautista-Expósito, S
   Martínez-Villaluenga, C
   Dueñas, M
   Silván, JM
   Frias, J
   Peñas, E
AF Bautista-Exposito, Sara
   Martinez-Villaluenga, Cristina
   Duenas, Montserrat
   Manuel Silvan, Jose
   Frias, Juana
   Penas, Elena
TI Combination of pH-controlled fermentation in mild acidic conditions and
   enzymatic hydrolysis by Savinase to improve metabolic health-promoting
   properties of lentil
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Lentil; pH-controlled fermentation; Lactobacillus plantarum; Savinase;
   Bioactivity; Metabolic syndrome
ID I-CONVERTING-ENZYME; SIMULATED GASTROINTESTINAL DIGESTION; GLUCOSIDASE
   INHIBITORY-ACTIVITY; LOW-DENSITY-LIPOPROTEIN; ALPHA-GLUCOSIDASE;
   ANTIOXIDANT ACTIVITIES; PHENOLIC-COMPOUNDS; OXIDATIVE STRESS;
   ANTIINFLAMMATORY ACTIVITIES; POLYPHENOLIC COMPOUNDS
AB This work evaluated the feasibility of pH-controlled fermentation by Lactobacillus plantarum CECT 748 combined with Savinase-hydrolysis (LPHS) for producing multifunctional lentil ingredients targeted for metabolic syndrome (MetS) relieving. LPHS process was compared with L. plantarum-fermentation (LP) and Savinase-hydrolysis (HS), applied separately. LPHS soluble fraction exhibited higher peptides, p-hydroxybenzoic acid, flavonols, antioxidant (400.74 mM TE/g), angiotensin I-converting enzyme (ACE) (95.43%) and alpha-glucosidase-inhibitory activities (40.55 and 25.03% for maltase and sacarase activities, respectively) than LP and HS. L. plantarum was responsible for the phenolic profile changes and sucrase inhibitory activity of LPHS while Savinase contributed to peptides release and ACE and maltase inhibitory and antioxidant activities. The most active LPHS fraction contained 3 peptides with potential biological activity and flavonoids and phenolic acids. LPHS simulated gastrointestinal digestion enhanced its peptides, phenolics, ACE-inhibitory and antioxidant activities. This study opens new opportunities regarding the production of lentil-multifunctional ingredients for MetS management.
C1 [Bautista-Exposito, Sara; Martinez-Villaluenga, Cristina; Manuel Silvan, Jose; Frias, Juana; Penas, Elena] CSIC, ICTAN, Inst Food Sci Technol & Nutr, Juan de la Cierva 3, Madrid 28006, Spain.
   [Duenas, Montserrat] Univ Salamanca, Fac Pharm, Nutr & Bromatol Unit, Res Grp Polyphenols, Campus Miguel Unamuno, Salamanca 37007, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Ciencia y Tecnologia de Alimentos y Nutricion (ICTAN); University of
   Salamanca
RP Peñas, E (corresponding author), CSIC, ICTAN, Inst Food Sci Technol & Nutr, Juan de la Cierva 3, Madrid 28006, Spain.
EM elenape@ictan.csic.es
RI Dueñas, M./A-8976-2016; Peñas, Elena/C-8557-2015; Martinez-Villaluenga,
   Cristina/AAK-7199-2021; Silvan Jimenez, Jose Manuel/F-3032-2013; Frias,
   Juana/F-6607-2013
OI Silvan Jimenez, Jose Manuel/0000-0001-8266-3761; Frias,
   Juana/0000-0003-0355-3113; Bautista Exposito, Sara/0000-0002-9099-2247
FU Ministry of Economy and Competitiveness (MINECO, Spain); FEDER program
   [AGL2013-43247-R]; MINECO; European Social Fund
FX The research leading to these results received funding from Ministry of
   Economy and Competitiveness (MINECO, Spain) and FEDER program (grant
   number AGL2013-43247-R). E. P. acknowledges to MINECO and European
   Social Fund for her "Ramon y Cajal" contract.
CR Afonso J, 2013, LWT-FOOD SCI TECHNOL, V54, P265, DOI 10.1016/j.lwt.2013.04.009
   Albuquerque BR, 2017, IND CROP PROD, V99, P150, DOI 10.1016/j.indcrop.2017.02.002
   Alshikh N, 2015, J FUNCT FOODS, V18, P1022, DOI 10.1016/j.jff.2015.05.018
   Amiri M, 2017, NUTRIENTS, V9, DOI 10.3390/nu9101106
   Martín MA, 2014, FOOD RES INT, V63, P400, DOI 10.1016/j.foodres.2014.05.006
   Barros L, 2013, IND CROP PROD, V44, P104, DOI 10.1016/j.indcrop.2012.11.003
   Bautista-Expósito S, 2018, FOOD CHEM, V257, P341, DOI 10.1016/j.foodchem.2018.03.044
   Bautista-Expósito S, 2018, FOOD CHEM, V248, P262, DOI 10.1016/j.foodchem.2017.12.059
   Bubelová Z, 2018, J FOOD PROCESS PRES, V42, DOI 10.1111/jfpp.13388
   Burgos-Edwards A, 2017, FOOD CHEM, V237, P1073, DOI 10.1016/j.foodchem.2017.06.060
   Daskaya-Dikmen C, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040316
   de Camargo AC, 2014, J AGR FOOD CHEM, V62, P12159, DOI 10.1021/jf504185s
   Elnakish MT, 2013, J PATHOL, V231, P290, DOI 10.1002/path.4255
   Orqueda ME, 2017, FOOD CHEM, V216, P70, DOI 10.1016/j.foodchem.2016.08.015
   Fontana Pereira D., 2011, Nutrition, V27, P1161
   Garcia-Mora P, 2015, FOOD CHEM, V171, P224, DOI 10.1016/j.foodchem.2014.08.116
   García-Mora P, 2017, FOOD CHEM, V221, P464, DOI 10.1016/j.foodchem.2016.10.087
   Garcia-Mora P, 2015, J FUNCT FOODS, V18, P319, DOI 10.1016/j.jff.2015.07.010
   Garcia-Mora P, 2014, J AGR FOOD CHEM, V62, P4166, DOI 10.1021/jf500849u
   Giusti F, 2017, FOOD CHEM, V221, P689, DOI 10.1016/j.foodchem.2016.11.118
   Grosso G, 2017, CRIT REV FOOD SCI, V57, P3218, DOI 10.1080/10408398.2015.1107021
   Gu YC, 2013, FOOD CHEM, V141, P2682, DOI 10.1016/j.foodchem.2013.04.064
   Guerrero L, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0049493
   Ho SY, 2017, LWT-FOOD SCI TECHNOL, V85, P232, DOI 10.1016/j.lwt.2017.07.028
   Ibrahim MA, 2018, CHEM BIOL DRUG DES, V91, P370, DOI 10.1111/cbdd.13105
   Torino MI, 2013, FOOD CHEM, V136, P1030, DOI 10.1016/j.foodchem.2012.09.015
   Iwaniak A, 2014, COMPR REV FOOD SCI F, V13, P114, DOI 10.1111/1541-4337.12051
   Jakubczyk A, 2017, FOOD RES INT, V100, P489, DOI 10.1016/j.foodres.2017.07.046
   Jakubczyk A, 2013, FOOD CHEM, V141, P3774, DOI 10.1016/j.foodchem.2013.06.095
   Kapravelou G, 2015, J SCI FOOD AGR, V95, P1207, DOI 10.1002/jsfa.6809
   Krishnan V, 2018, FOOD CHEM, V245, P246, DOI 10.1016/j.foodchem.2017.10.099
   Kwaw E, 2018, FOOD CHEM, V250, P148, DOI 10.1016/j.foodchem.2018.01.009
   Li N, 2012, J AGR FOOD CHEM, V60, P12531, DOI 10.1021/jf304116s
   Li YW, 2011, J PEPT SCI, V17, P454, DOI 10.1002/psc.1345
   Limón RI, 2015, FOOD CHEM, V172, P343, DOI 10.1016/j.foodchem.2014.09.084
   Liu CL, 2018, FOOD CHEM, V245, P471, DOI 10.1016/j.foodchem.2017.10.095
   Liu MJ, 2010, BMC GENOMICS, V11, DOI 10.1186/1471-2164-11-36
   López A, 2017, J FOOD PROCESS PRES, V41, DOI 10.1111/jfpp.13113
   Mamilla RK, 2017, LWT-FOOD SCI TECHNOL, V75, P51, DOI 10.1016/j.lwt.2016.08.036
   Martínez R, 2016, BRIT J NUTR, V116, P402, DOI 10.1017/S0007114516001963
   Miao J, 2018, FOOD CHEM, V248, P330, DOI 10.1016/j.foodchem.2017.12.018
   Minekus M, 2014, FOOD FUNCT, V5, P1113, DOI 10.1039/c3fo60702j
   Mojica L, 2017, J SCI FOOD AGR, V97, P2401, DOI 10.1002/jsfa.8053
   Muñoz R, 2017, FERMENTED FOODS IN HEALTH AND DISEASE PREVENTION, P63, DOI 10.1016/B978-0-12-802309-9.00004-2
   Natesh R, 2003, NATURE, V421, P551, DOI 10.1038/nature01370
   Nishimura H, 2017, ANAT SCI INT, V92, P215, DOI 10.1007/s12565-016-0372-8
   Oomah BD, 2011, FOOD RES INT, V44, P436, DOI 10.1016/j.foodres.2010.09.027
   Delgado MCO, 2016, FOOD CHEM, V197, P1160, DOI 10.1016/j.foodchem.2015.11.092
   Padhi EMT, 2017, J FUNCT FOODS, V38, P602, DOI 10.1016/j.jff.2016.11.006
   Pellegrini M, 2017, J FUNCT FOODS, V38, P77, DOI 10.1016/j.jff.2017.08.042
   Peng X, 2016, FOOD CHEM, V190, P207, DOI 10.1016/j.foodchem.2015.05.088
   Pradeep PM, 2018, FOOD CHEM, V247, P46, DOI 10.1016/j.foodchem.2017.11.103
   Rodríguez H, 2009, INT J FOOD MICROBIOL, V132, P79, DOI 10.1016/j.ijfoodmicro.2009.03.025
   Rodríguez-Monforte M, 2017, EUR J NUTR, V56, P925, DOI 10.1007/s00394-016-1305-y
   Santhekadur PK, 2017, BIOMED PHARMACOTHER, V92, P826, DOI 10.1016/j.biopha.2017.05.136
   Savikin K, 2018, IND CROP PROD, V113, P142, DOI 10.1016/j.indcrop.2018.01.031
   Simsek M, 2017, FOOD FUNCT, V8, P1915, DOI [10.1039/c7fo00015d, 10.1039/C7FO00015D]
   Söhretoglu D, 2018, INT J BIOL MACROMOL, V108, P81, DOI 10.1016/j.ijbiomac.2017.11.151
   Starzynska-Janiszewska A, 2014, J SCI FOOD AGR, V94, P359, DOI 10.1002/jsfa.6385
   Tian M, 2015, DAIRY SCI TECHNOL, V95, P451, DOI 10.1007/s13594-015-0226-5
   Vilcacundo R, 2017, J FUNCT FOODS, V35, P531, DOI 10.1016/j.jff.2017.06.024
   Wang TT, 2015, J FUNCT FOODS, V13, P276, DOI 10.1016/j.jff.2014.12.049
   World Health Organization, 2013, Global action plan on physical activity 2018-2030: more active people for a healthier world
   Xu MW, 2018, FOOD CHEM, V250, P140, DOI 10.1016/j.foodchem.2018.01.049
   Yang RW, 2017, FOOD CHEM, V219, P311, DOI 10.1016/j.foodchem.2016.09.163
   Zhang B, 2017, J FUNCT FOODS, V32, P248, DOI 10.1016/j.jff.2017.03.004
   Zhang B, 2015, FOOD CHEM, V172, P862, DOI 10.1016/j.foodchem.2014.09.144
   Zhang Y, 2016, PEPTIDES, V76, P45, DOI 10.1016/j.peptides.2015.12.004
   Zhu QY, 2002, J AGR FOOD CHEM, V50, P1700, DOI 10.1021/jf011228o
NR 69
TC 15
Z9 17
U1 1
U2 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD SEP
PY 2018
VL 48
BP 9
EP 18
DI 10.1016/j.jff.2018.06.019
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA GX2TS
UT WOS:000447573600002
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Burke, V
AF Burke, Valerie
TI Obesity in childhood and cardiovascular risk
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article; Proceedings Paper
CT Joint Meeting of the
   Australian-Physiological-Society/Australian-Biophysics-Society
CY DEC 06-07, 2005
CL Melbourne, AUSTRALIA
SP Australian Physiol Soc, Australian Biophys Soc
DE blood pressure; child; lipids; metabolic syndrome; obesity
ID BODY-MASS INDEX; HEALTH-RELATED BEHAVIORS; PHYSICAL-ACTIVITY;
   YOUNG-ADULTS; AUSTRALIAN CHILDREN; BLOOD-PRESSURE; FOLLOW-UP; OVERWEIGHT
   CHILDREN; INSULIN-RESISTANCE; DIABETES-MELLITUS
AB Childhood obesity is increasing worldwide and is associated with an increase in cardiovascular risk factors in childhood.
   In children, obesity is associated with hypertension, impaired vascular function, dyslipidaemia, atheroma, the metabolic syndrome, type 2 diabetes, systemic inflammation and oxidative stress. Greater risk is associated with clustering of risk factors.
   Obesity tracks from childhood to adult life and predicts adverse levels of risk and an increase in cardiovascular end-points.
   Adults who were obese as children have higher rates of obesity and its sequelae: greater intima-media thickness, left ventricular hypertrophy and atherosclerosis. There is greater all-cause and cardiovascular mortality, as well as a greater risk of stroke, in long-term follow-up of obese children.
   Genetic and environmental factors contribute to familial aggregation of obesity, with parental obesity as a strong predictor of obesity in children. However, clustering of adverse health-related behaviours is seen in such families.
   Adverse behaviours (smoking, poor dietary choices, less physical activity and greater alcohol intake) also cluster in individuals, suggesting the need for multimodal interventions.
   Recognition of families at risk offers opportunities for prevention of obesity in children and decreasing risk in parents.
C1 Univ Western Australia, Sch Med & Pharmacol, Royal Perth Hosp Unit, Perth, WA 6847, Australia.
   Cardiovasc Res Ctr, Perth, WA, Australia.
C3 University of Western Australia; East Metropolitan Health Service; Royal
   Perth Hospital
RP Burke, V (corresponding author), Univ Western Australia, Sch Med & Pharmacol, Royal Perth Hosp Unit, POB X2213, Perth, WA 6847, Australia.
EM vburke@cyllene.uwa.edu.au
CR ALLISON DB, 1999, PRIMARY SECONDARY PR, P147
   [Anonymous], 2000, Pediatrics, V105, P671
   Arenz S, 2004, INT J OBESITY, V28, P1247, DOI 10.1038/sj.ijo.0802758
   BAO WH, 1994, ARCH INTERN MED, V154, P1842
   Bao WH, 1996, CIRCULATION, V93, P54, DOI 10.1161/01.CIR.93.1.54
   Berenson G.S., 1986, CAUSATION CARDIOVASC
   BERENSON GS, 1992, AM J CARDIOL, V70, P851, DOI 10.1016/0002-9149(92)90726-F
   Booth ML, 2003, AM J CLIN NUTR, V77, P29, DOI 10.1093/ajcn/77.1.29
   Burke V, 2005, J PEDIATR-US, V147, P56, DOI 10.1016/j.jpeds.2005.03.038
   Burke V, 2005, INT J OBESITY, V29, P15, DOI 10.1038/sj.ijo.0802750
   Burke V, 2004, PREV MED, V39, P722, DOI 10.1016/j.ypmed.2004.02.038
   Burke V, 2004, PREV MED, V38, P558, DOI 10.1016/j.ypmed.2003.09.023
   Burke V, 1997, PREV MED, V26, P724, DOI 10.1006/pmed.1997.0198
   Burke V, 2001, INT J OBESITY, V25, P147, DOI 10.1038/sj.ijo.0801538
   Burke V, 1998, J PEDIATR-US, V133, P206, DOI 10.1016/S0022-3476(98)70221-5
   Burke V, 1998, J HYPERTENS, V16, P269, DOI 10.1097/00004872-199816030-00003
   Chen W, 1999, ATHEROSCLEROSIS, V145, P197, DOI 10.1016/S0021-9150(99)00025-8
   Cook S, 2003, ARCH PEDIAT ADOL MED, V157, P821, DOI 10.1001/archpedi.157.8.821
   Curhan GC, 1996, CIRCULATION, V94, P3246, DOI 10.1161/01.CIR.94.12.3246
   Davison KK, 2005, J PEDIATR-US, V147, P436, DOI 10.1016/j.jpeds.2005.05.002
   DIETZ WH, 1985, PEDIATRICS, V75, P807
   DIPIETRO L, 1994, INT J OBESITY, V18, P585
   Eisenmann JC, 2002, OBES RES, V10, P379, DOI 10.1038/oby.2002.52
   FOX NL, 1990, INT J EPIDEMIOL, V19, P66, DOI 10.1093/ije/19.1.66
   Freedman D. S., 2002, Child and adolescent obesity: causes and consequences, prevention and management, P221, DOI 10.1017/CBO9780511544675.013
   Freedman DS, 2005, PEDIATRICS, V115, P22, DOI 10.1542/peds.2004-0220
   Goodman E, 2005, CIRCULATION, V111, P1970, DOI 10.1161/01.CIR.0000161957.34198.2B
   Goran MI, 2003, J CLIN ENDOCR METAB, V88, P1417, DOI 10.1210/jc.2002-021442
   Grummer-Strawn LM, 2004, PEDIATRICS, V113, P81
   Gunnell DJ, 1998, AM J CLIN NUTR, V67, P1111, DOI 10.1093/ajcn/67.6.1111
   Guo SS, 2002, AM J CLIN NUTR, V76, P653, DOI 10.1093/ajcn/76.3.653
   Halle M, 2004, EXERC IMMUNOL REV, V10, P66
   Harder T, 2005, AM J EPIDEMIOL, V162, P397, DOI 10.1093/aje/kwi222
   HAVLIK RJ, 1979, AM J EPIDEMIOL, V110, P304, DOI 10.1093/oxfordjournals.aje.a112815
   HEDIGER ML, 2001, JAMA-J AM MED ASSOC, V285, P2461
   HOLMAN RL, 1958, AM J PATHOL, V34, P209
   LAUER RM, 1988, PEDIATRICS, V82, P309
   Lawlor DA, 2005, CIRCULATION, V111, P1891, DOI 10.1161/01.CIR.0000161798.45728.4D
   Lazarus R, 2000, INT J OBESITY, V24, P679, DOI 10.1038/sj.ijo.0801218
   Li SX, 2003, JAMA-J AM MED ASSOC, V290, P2271, DOI 10.1001/jama.290.17.2271
   Li XR, 2004, CIRCULATION, V110, P3488, DOI 10.1161/01.CIR.0000149713.48317.27
   Magarey AM, 2001, MED J AUSTRALIA, V174, P561, DOI 10.5694/j.1326-5377.2001.tb143435.x
   MALCOLM DD, 1993, PEDIATRICS, V92, P703
   MALLORY GB, 1989, J PEDIATR-US, V115, P892, DOI 10.1016/S0022-3476(89)80738-3
   Marshall SJ, 2004, INT J OBESITY, V28, P1238, DOI 10.1038/sj.ijo.0802706
   McGill HC, 1998, ARTERIOSCL THROM VAS, V18, P1108, DOI 10.1161/01.ATV.18.7.1108
   McGill HC, 1997, ARTERIOSCL THROM VAS, V17, P95, DOI 10.1161/01.ATV.17.1.95
   MCGILL HC, 1995, ARTERIOSCL THROM VAS, V15, P431, DOI 10.1161/01.ATV.15.4.431
   McMahon SK, 2004, MED J AUSTRALIA, V180, P459, DOI 10.5694/j.1326-5377.2004.tb06023.x
   MIDGETTE AS, 1993, AM J EPIDEMIOL, V307, P1381
   MUST A, 1992, NEW ENGL J MED, V327, P1350, DOI 10.1056/NEJM199211053271904
   NIETO FJ, 1992, AM J EPIDEMIOL, V136, P201, DOI 10.1093/oxfordjournals.aje.a116486
   O'Dea JA, 2003, MED J AUSTRALIA, V179, P63, DOI 10.5694/j.1326-5377.2003.tb05430.x
   Ong KKL, 2000, BRIT MED J, V320, P967, DOI 10.1136/bmj.320.7240.967
   Parsons TJ, 1999, INT J OBESITY, V23, pS1
   Pearson TA, 2003, CIRCULATION, V107, P499, DOI 10.1161/01.CIR.0000052939.59093.45
   Pérusse L, 2005, OBES RES, V13, P381, DOI 10.1038/oby.2005.50
   Pinhas-Hamiel O, 2005, J PEDIATR-US, V146, P693, DOI 10.1016/j.jpeds.2004.12.042
   Power C, 2002, INT J EPIDEMIOL, V31, P413, DOI 10.1093/ije/31.2.413
   RAITAKARI OT, 1995, AM J EPIDEMIOL, V142, P36, DOI 10.1093/oxfordjournals.aje.a117543
   Rosenbloom AL, 1999, DIABETES CARE, V22, P345, DOI 10.2337/diacare.22.2.345
   SALLIS JF, 1993, CRIT REV FOOD SCI, V33, P403, DOI 10.1080/10408399309527639
   Silventoinen K, 2004, INT J OBESITY, V28, P710, DOI 10.1038/sj.ijo.0802614
   Sinaiko AR, 2005, CIRCULATION, V111, P1985, DOI 10.1161/01.CIR.0000161837.23846.57
   Singhal A, 2005, P NUTR SOC, V64, P15, DOI 10.1079/PNS2004404
   Sinha R, 2002, NEW ENGL J MED, V346, P802, DOI 10.1056/NEJMoa012578
   Srinivasan SR, 1996, METABOLISM, V45, P235, DOI 10.1016/S0026-0495(96)90060-8
   Stubbs CO, 2004, MED J AUSTRALIA, V181, P489, DOI 10.5694/j.1326-5377.2004.tb06406.x
   TARAS HL, 1995, ARCH PEDIAT ADOL MED, V149, P649, DOI 10.1001/archpedi.1995.02170190059010
   Uauy R., 2004, OBES REV INTERNET, V5, P4, DOI [10.1111/j.1467-789X.2004.00133.x, DOI 10.1111/J.1467-789X.2004.00133.X]
   UNGEMACK JA, 1994, AM J PREV MED, V10, P38, DOI 10.1016/S0749-3797(18)30645-7
   Urbina EM, 2005, AM J HYPERTENS, V18, P767, DOI 10.1016/j.amjhyper.2004.12.017
   Viikari JSA, 2004, ACTA PAEDIATR, V93, P34, DOI 10.1080/08035320410022721
   von Kries R, 2002, AM J EPIDEMIOL, V156, P954, DOI 10.1093/aje/kwf128
   Wang YF, 2000, AM J CLIN NUTR, V72, P1018
   Weiss R, 2005, BEST PRACT RES CL EN, V19, P405, DOI 10.1016/j.beem.2005.04.009
   Whitaker RC, 1997, NEW ENGL J MED, V337, P869, DOI 10.1056/NEJM199709253371301
   Whitaker RC, 1998, J PEDIATR-US, V132, P768, DOI 10.1016/S0022-3476(98)70302-6
NR 78
TC 66
Z9 90
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1870
EI 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD SEP
PY 2006
VL 33
IS 9
BP 831
EP 837
DI 10.1111/j.1440-1681.2006.04449.x
PG 7
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Pharmacology & Pharmacy; Physiology
GA 072FM
UT WOS:000239659300013
PM 16922816
DA 2025-06-11
ER

PT J
AU Jarmakiewicz-Czaja, S
   Sokal, A
   Pardak, P
   Filip, R
AF Jarmakiewicz-Czaja, Sara
   Sokal, Aneta
   Pardak, Piotr
   Filip, Rafal
TI Glucocorticosteroids and the Risk of NAFLD in Inflammatory Bowel Disease
SO CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Review
ID FATTY LIVER-DISEASE; ANTI-SACCHAROMYCES-CEREVISIAE; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; HEPATIC STEATOSIS; CARDIORESPIRATORY FITNESS;
   AMINOTRANSFERASE LEVELS; INSULIN-RESISTANCE; BARIATRIC SURGERY;
   OXIDATIVE STRESS
AB Each year, the incidence of nonalcoholic fatty liver (NAFLD) disease increases. NAFLD is a chronic disease. One of the most common causes of NAFLD is an inadequate lifestyle, which is characterized by a lack or low physical activity and eating highly processed foods rich in saturated fat and salt and containing low amount of fiber. Moreover, disturbances in intestinal microbiome and the use of certain drugs may predispose to NAFLD. NAFLD is an increasingly described disease in patients with inflammatory bowel disease (IBD). Recent data also indicate a frequent coexistence of metabolic syndrome in this group of patients. Certain groups of drugs also increase the risk of developing inflammation, liver fibrosis, and cirrhosis. Particularly important in the development of NAFLD are steroids, which are used in the treatment of many diseases, for example, IBD. NAFLD is one of the most frequent parenteral manifestations of the disease in IBD patients. However, there is still insufficient information on what dose and exposure time of selected types of steroids may lead to the development of NAFLD. It is necessary to conduct further research in this direction. Therefore, patients with IBD should be constantly monitored for risk factors for the development of NAFLD.
C1 [Jarmakiewicz-Czaja, Sara; Sokal, Aneta] Rzeszow Univ, Inst Hlth Sci, Med Coll, PL-35959 Rzeszow, Poland.
   [Pardak, Piotr; Filip, Rafal] Rzeszow Univ, Inst Med, Med Coll, PL-35959 Rzeszow, Poland.
   [Pardak, Piotr; Filip, Rafal] Clin Hosp, Dept Gastroenterol, IBD Unit, 2, PL-35301 Rzeszow, Poland.
C3 University of Rzeszow; University of Rzeszow
RP Filip, R (corresponding author), Rzeszow Univ, Inst Med, Med Coll, PL-35959 Rzeszow, Poland.; Filip, R (corresponding author), Clin Hosp, Dept Gastroenterol, IBD Unit, 2, PL-35301 Rzeszow, Poland.
EM sjczaja@ur.edu.pl; asokal@ur.edu.pl; piotrpardak@wp.pl; r.s.filip@wp.pl
RI Sokal-Dembowska, Aneta/KZU-3915-2024; Jarmakiewicz - Czaja,
   Sara/AFT-7035-2022; Filip, Rafal/O-4277-2019
OI Sokal-Dembowska, Aneta/0000-0003-4727-8766; Jarmakiewicz-Czaja,
   Sara/0000-0001-6896-4744
CR Adams LC, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0206450
   Adinolfi LE, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17060803
   Ahmed A, 2012, ALIMENT PHARM THER, V36, P1097, DOI 10.1111/apt.12078
   Al-Mohannadi M.P.C., 2020, OPEN J GASTROENTEROL, V3, P40, DOI [10.28933/ojgh-2020-08-2805, DOI 10.28933/OJGH-2020-08-2805]
   Allard Julien, 2019, Adv Pharmacol, V85, P75, DOI 10.1016/bs.apha.2019.01.003
   Ampong I, 2020, BRIT J NUTR, V123, P601, DOI 10.1017/S0007114519003064
   Aranda CJ, 2019, FASEB J, V33, P14067, DOI 10.1096/fj.201900404RR
   Aron-Wisnewsky J, 2020, NAT REV GASTRO HEPAT, V17, P279, DOI 10.1038/s41575-020-0269-9
   Aron-Wisnewsky J, 2020, GASTROENTEROLOGY, V158, P1881, DOI 10.1053/j.gastro.2020.01.049
   Baba CS, 2006, J GASTROEN HEPATOL, V21, P191, DOI 10.1111/j.1440-1746.2005.04233.x
   Barrett K, 2018, BRIT J GEN PRACT, V68, P497, DOI 10.3399/bjgp18X699341
   Bassuk SS, 2005, J APPL PHYSIOL, V99, P1193, DOI 10.1152/japplphysiol.00160.2005
   Bergheim I, 2008, J HEPATOL, V48, P983, DOI 10.1016/j.jhep.2008.01.035
   Bessissow T, 2016, INFLAMM BOWEL DIS, V22, P1937, DOI 10.1097/MIB.0000000000000832
   Brunner KT, 2019, CURR OBES REP, V8, P220, DOI 10.1007/s13679-019-00345-1
   Bucci L, 2017, LIVER INT, V37, P259, DOI 10.1111/liv.13204
   Byrne CD, 2015, J HEPATOL, V62, pS47, DOI 10.1016/j.jhep.2014.12.012
   Campbell JE, 2011, AM J PHYSIOL-CELL PH, V300, pC198, DOI 10.1152/ajpcell.00045.2010
   Cani PD, 2007, DIABETES, V56, P1761, DOI 10.2337/db06-1491
   Carr RM, 2017, DIGEST DIS SCI, V62, P1354, DOI 10.1007/s10620-017-4495-0
   Chanson P, 2010, NEUROENDOCRINOLOGY, V92, P96, DOI 10.1159/000314272
   Chen JZ, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21155214
   Cheng FKF, 2014, J VIRAL HEPATITIS, V21, P1, DOI 10.1111/jvh.12172
   Corbin KD, 2012, CURR OPIN GASTROEN, V28, P159, DOI 10.1097/MOG.0b013e32834e7b4b
   Cushing K, 2021, JAMA-J AM MED ASSOC, V325, P69, DOI 10.1001/jama.2020.18936
   D'souza AM, 2012, AM J PHYSIOL-GASTR L, V302, pG850, DOI 10.1152/ajpgi.00378.2011
   de Guia RM, 2020, DIABETES METAB SYND, V14, P1273, DOI 10.1016/j.dsx.2020.06.038
   De Lorenzo S, 2020, CANCERS, V12, DOI 10.3390/cancers12113182
   Del Campo JA, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19030911
   Dolinsky VW, 2004, BIOCHEM J, V378, P967, DOI 10.1042/BJ20031320
   Duseja A, 2013, HEPATOL INT, V7, pS755, DOI 10.1007/s12072-013-9480-x
   El Hadi H, 2018, ANTIOXIDANTS-BASEL, V7, DOI 10.3390/antiox7010012
   Eom T, 2018, J MICROBIOL, V56, P189, DOI 10.1007/s12275-018-8049-8
   Ethgen O, 2013, CURR MED RES OPIN, V29, P1147, DOI 10.1185/03007995.2013.818531
   Fakhry TK, 2019, SURG OBES RELAT DIS, V15, P502, DOI 10.1016/j.soard.2018.12.002
   Famouri F, 2017, J PEDIATR GASTR NUTR, V64, P413, DOI 10.1097/MPG.0000000000001422
   Fazel Y, 2016, METABOLISM, V65, P1017, DOI 10.1016/j.metabol.2016.01.012
   Feng Y, 2020, CELL STRESS CHAPERON, V25, P47, DOI 10.1007/s12192-019-01034-7
   Findlay AR, 2015, MUSCLE NERVE, V51, P638, DOI 10.1002/mus.24566
   Fröhlich M, 2000, DIABETES CARE, V23, P1835, DOI 10.2337/diacare.23.12.1835
   Furll M, 1993, Tierarztl Prax, V21, P503
   Furll M, 1993, Tierarztl Prax, V21, P399
   Galecka M., 2018, M DICA, V12, P50
   Gao ZG, 2004, MOL ENDOCRINOL, V18, P2024, DOI 10.1210/me.2003-0383
   Gathercole LL, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026223
   Golabi P, 2016, WORLD J GASTROENTERO, V22, P6318, DOI 10.3748/wjg.v22.i27.6318
   Granito A, 2006, GUT, V55, P296
   Granito A, 2005, ALIMENT PHARM THER, V21, P881, DOI 10.1111/j.1365-2036.2005.02417.x
   Hannah WN Jr, 2016, CLIN LIVER DIS, V20, P339, DOI 10.1016/j.cld.2015.10.008
   Harper JW, 2016, WORLD J GASTROENTERO, V22, P7868, DOI 10.3748/wjg.v22.i35.7868
   Hashimoto E, 2013, J GASTROEN HEPATOL, V28, P64, DOI 10.1111/jgh.12271
   Hoffmann P, 2020, WORLD J GASTROENTERO, V26, P7367, DOI 10.3748/wjg.v26.i46.7367
   Houttu V, 2020, THER ADV GASTROENTER, V13, DOI 10.1177/1756284820941745
   Isomaa B, 2003, LIFE SCI, V73, P2395, DOI 10.1016/S0024-3205(03)00646-5
   Jarmakiewicz-Czaja S, 2020, NUTRIENTS, V12, DOI 10.3390/nu12103073
   Jena PK, 2020, HEPATOBIL SURG NUTR, V9, P170, DOI 10.21037/hbsn.2019.09.07
   Ji HF, 2014, NUTRITION, V30, P986, DOI 10.1016/j.nut.2014.01.016
   Johnson NA, 2010, HEPATOLOGY, V52, P370, DOI 10.1002/hep.23711
   Jung UJ, 2014, INT J MOL SCI, V15, P6184, DOI 10.3390/ijms15046184
   Kang JH, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054617
   Kang MK, 2020, DIGEST DIS, V38, P507, DOI 10.1159/000506938
   Kantartzis K, 2009, GUT, V58, P1281, DOI 10.1136/gut.2008.151977
   Kasturi S, 2016, RHEUM DIS CLIN N AM, V42, P47, DOI 10.1016/j.rdc.2015.08.007
   Kavanagh K, 2013, AM J CLIN NUTR, V98, P349, DOI 10.3945/ajcn.112.057331
   Kechagias S, 2008, GUT, V57, P649, DOI 10.1136/gut.2007.131797
   Kim D, 2018, CLIN LIVER DIS, V22, P133, DOI 10.1016/j.cld.2017.08.010
   Kistler KD, 2011, AM J GASTROENTEROL, V106, P460, DOI 10.1038/ajg.2010.488
   Knobler H, 1999, QJM-MON J ASSOC PHYS, V92, P73, DOI 10.1093/qjmed/92.2.73
   Krawczyk M, 2020, GASTROENTEROLOGY, V158, P1865, DOI 10.1053/j.gastro.2020.01.053
   Lallukka S, 2016, BEST PRACT RES CL EN, V30, P385, DOI [10.101, 10.1016/j.beem.2016.06.006]
   Lapumnuaypol K, 2018, EUR J GASTROEN HEPAT, V30, P854, DOI 10.1097/MEG.0000000000001144
   Lazarus JV, 2020, J HEPATOL, V72, P14, DOI 10.1016/j.jhep.2019.08.027
   Leclercq IA, 2008, CURR OPIN CLIN NUTR, V11, P766, DOI 10.1097/MCO.0b013e328312c353
   Likhitsup A, 2019, ANN GASTROENTEROL, V32, P283, DOI 10.20524/aog.2019.0371
   Liu L, 2019, DIGEST DIS SCI, V64, P3402, DOI 10.1007/s10620-019-05699-z
   Liu Q, 2019, EXP THER MED, V18, P1935, DOI 10.3892/etm.2019.7781
   Liu WX, 2021, EUR J NUTR, V60, P2317, DOI 10.1007/s00394-020-02431-w
   Loman BR, 2018, NUTR REV, V76, P822, DOI 10.1093/nutrit/nuy031
   Maciejewska D, 2018, POSTEP HIG MED DOSW, V72, P659, DOI 10.5604/01.3001.0012.2054
   Magann EF, 2017, ACTA OBSTET GYN SCAN, V96, P395, DOI 10.1111/aogs.13104
   Mantovani A, 2018, DIABETES CARE, V41, P372, DOI 10.2337/dc17-1902
   Marino JS, 2016, J BIOL CHEM, V291, P25776, DOI 10.1074/jbc.M116.752311
   Matsuoka K, 2015, SEMIN IMMUNOPATHOL, V37, P47, DOI 10.1007/s00281-014-0454-4
   Mazidi M, 2019, J AM COLL NUTR, V38, P633, DOI 10.1080/07315724.2018.1507011
   McCracken E, 2018, CLIN DERMATOL, V36, P14, DOI 10.1016/j.clindermatol.2017.09.004
   McDowell C., 2022, Inflammatory bowel disease
   Mehta AB, 2016, INDIAN J DERMATOL VE, V82, P371, DOI 10.4103/0378-6323.178903
   Miele L, 2009, HEPATOLOGY, V49, P1877, DOI 10.1002/hep.22848
   Milic S, 2014, WORLD J GASTROENTERO, V20, P9330, DOI 10.3748/wjg.v20.i28.9330
   Moon BC, 2012, ARTERIOSCL THROM VAS, V32, P236, DOI 10.1161/ATVBAHA.111.241356
   Mummadi RR, 2008, CLIN GASTROENTEROL H, V6, P1396, DOI 10.1016/j.cgh.2008.08.012
   Mundi MS, 2020, NUTR CLIN PRACT, V35, P72, DOI 10.1002/ncp.10449
   Nagashimada M, 2019, IUBMB LIFE, V71, P516, DOI 10.1002/iub.1991
   Palumbo CS, 2019, INFLAMM BOWEL DIS, V25, P124, DOI 10.1093/ibd/izy200
   Pälve KS, 2017, MED SCI SPORT EXER, V49, P1834, DOI 10.1249/MSS.0000000000001288
   Pan XR, 1997, DIABETES CARE, V20, P537, DOI 10.2337/diacare.20.4.537
   Papathanasopoulos A, 2010, GASTROENTEROLOGY, V138, P65, DOI 10.1053/j.gastro.2009.11.045
   Partridge D, 2019, NUTR BULL, V44, P329, DOI 10.1111/nbu.12408
   Perdomo CM, 2019, NUTRIENTS, V11, DOI 10.3390/nu11030677
   Perumpail BJ, 2017, WORLD J GASTROENTERO, V23, P8263, DOI 10.3748/wjg.v23.i47.8263
   Pimpin L, 2018, J HEPATOL, V69, P718, DOI 10.1016/j.jhep.2018.05.011
   Polyzos SA, 2019, METABOLISM, V92, P82, DOI 10.1016/j.metabol.2018.11.014
   Polyzos SA, 2017, MINERVA ENDOCRINOL, V42, P92, DOI 10.23736/S0391-1977.16.02563-3
   Principi M, 2018, INFLAMM BOWEL DIS, V24, P1589, DOI 10.1093/ibd/izy051
   Rahimi L, 2020, DIABET METAB SYND OB, V13, P1133, DOI 10.2147/DMSO.S247379
   Ranjbar G, 2019, METABOLISM, V101, DOI 10.1016/j.metabol.2019.154001
   Rector RS, 2008, J PHYSIOL-LONDON, V586, P4241, DOI 10.1113/jphysiol.2008.156745
   Rector RS, 2011, J APPL PHYSIOL, V111, P1828, DOI 10.1152/japplphysiol.00384.2011
   Rietman A, 2018, EUR J CLIN NUTR, V72, P117, DOI 10.1038/ejcn.2017.148
   Rinella ME, 2015, JAMA-J AM MED ASSOC, V313, P2263, DOI 10.1001/jama.2015.5370
   Ruscica M, 2019, NUTR J, V18, DOI 10.1186/s12937-019-0438-2
   Sandberg JC, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0151985
   Santoleri D, 2019, CELL MOL GASTROENTER, V7, P447, DOI 10.1016/j.jcmgh.2018.10.016
   Sartini A, 2018, CELL DEATH DIS, V9, DOI 10.1038/s41419-017-0124-2
   Schwimmer JB, 2009, GASTROENTEROLOGY, V136, P1585, DOI 10.1053/j.gastro.2009.01.050
   Sharpton SR, 2019, AM J CLIN NUTR, V110, P139, DOI 10.1093/ajcn/nqz042
   Singh S, 2017, NAT REV GASTRO HEPAT, V14, P110, DOI 10.1038/nrgastro.2016.181
   Singh S, 2017, WORLD J GASTROENTERO, V23, P6549, DOI 10.3748/wjg.v23.i36.6549
   Sourianarayanane Achuthan, 2013, J Crohns Colitis, V7, pe279, DOI 10.1016/j.crohns.2012.10.015
   Spruss A, 2009, HEPATOLOGY, V50, P1094, DOI 10.1002/hep.23122
   Suk KT, 2019, EXPERT REV GASTROENT, V13, P193, DOI 10.1080/17474124.2019.1569513
   Sun ZQ, 2019, INT J CLIN EXP PATHO, V12, P3022
   Taira R, 2015, J CLIN BIOCHEM NUTR, V56, P149, DOI 10.3164/jcbn.14-74
   ter Horst KW, 2017, NUTRIENTS, V9, DOI 10.3390/nu9090981
   Thiesen A, 2003, DIGESTION, V68, P109, DOI 10.1159/000074524
   Thiesen A, 2002, LIPIDS, V37, P159, DOI 10.1007/s11745-002-0876-4
   Tovoli F, 2018, ALIMENT PHARM THER, V48, P538, DOI 10.1111/apt.14910
   Valentini L, 2011, EUR J INTERN MED, V22, P13, DOI 10.1016/j.ejim.2010.07.021
   van der Windt Dirk J., 2018, Gene Expression-The Journal of Liver Research, V18, P89, DOI 10.3727/105221617X15124844266408
   van Zutphen T, 2016, J HEPATOL, V65, P1198, DOI 10.1016/j.jhep.2016.05.046
   Vegiopoulos A, 2007, MOL CELL ENDOCRINOL, V275, P43, DOI 10.1016/j.mce.2007.05.015
   Vitellius G, 2018, ANN ENDOCRINOL-PARIS, V79, P98, DOI 10.1016/j.ando.2018.03.001
   Wang CC, 2020, ALIMENT PHARM THER, V51, P216, DOI 10.1111/apt.15575
   Wong VWS, 2013, J HEPATOL, V59, P536, DOI 10.1016/j.jhep.2013.04.013
   Woods CP, 2015, J STEROID BIOCHEM, V154, P94, DOI 10.1016/j.jsbmb.2015.07.020
   Yadav D, 2002, AM J GASTROENTEROL, V97, P2634, DOI 10.1111/j.1572-0241.2002.06041.x
   Yan JH, 2019, HEPATOLOGY, V69, P2414, DOI 10.1002/hep.30320
   Yki-Järvinen H, 2014, LANCET DIABETES ENDO, V2, P901, DOI 10.1016/S2213-8587(14)70032-4
   Yorulmaz E, 2011, SAUDI J GASTROENTERO, V17, P376, DOI 10.4103/1319-3767.87177
   Younossi Z, 2019, HEPATOLOGY, V69, P2672, DOI 10.1002/hep.30251
   Younossi ZM, 2019, J HEPATOL, V71, P793, DOI 10.1016/j.jhep.2019.06.021
   Yu CY, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0015188
   Zelber-Sagi S, 2008, HEPATOLOGY, V48, P1791, DOI 10.1002/hep.22525
   Zhang ZX, 2019, CURR OPIN CLIN NUTR, V22, P449, DOI 10.1097/MCO.0000000000000605
   Zhao HM, 2020, FRONT NUTR, V7, DOI 10.3389/fnut.2020.593735
   Zhou JH, 2020, HEPATOLOGY, V71, P1851, DOI 10.1002/hep.31150
   Zhou X, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0115148
   Zolfaghari H, 2016, INT J PREVENTIVE MED, V7, DOI 10.4103/2008-7802.188083
   Zou ZY, 2019, INFLAMM BOWEL DIS, V25, P1764, DOI 10.1093/ibd/izz043
NR 149
TC 8
Z9 8
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2291-2789
EI 2291-2797
J9 CAN J GASTROENTEROL
JI Can. J. Gastroenterol. Hepatol.
PD MAY 11
PY 2022
VL 2022
AR 4344905
DI 10.1155/2022/4344905
PG 13
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 1S3GV
UT WOS:000803943600002
PM 35600209
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Leibold, S
   Lakshminarasimha, AB
   Gremse, F
   Hammerschmidt, M
   Michel, M
AF Leibold, Sandra
   Lakshminarasimha, Amrutha Bagivalu
   Gremse, Felix
   Hammerschmidt, Matthias
   Michel, Maximilian
TI Long-term obesogenic diet leads to metabolic phenotypes which are not
   exacerbated by catch-up growth in zebrafish
SO PLOS ONE
LA English
DT Article
ID COMPENSATORY GROWTH; ENERGY-EXPENDITURE; OXIDATIVE STRESS; INDUCED
   OBESITY; PRETERM BIRTH; INFANCY; LIFE; DEFICIENCY; DEPOSITION;
   RESISTANCE
AB Obesity and metabolic syndrome are of increasing global concern. In order to understand the basic biology and etiology of obesity, research has turned to animals across the vertebrate spectrum including zebrafish. Here, we carefully characterize zebrafish in a long-term obesogenic environment as well as zebrafish that went through early lifetime caloric restriction. We found that long-term obesity in zebrafish leads to metabolic endpoints comparable to mammals including increased adiposity, weight, hepatic steatosis and hepatic lesions but not signs of glucose dysregulation or differences in metabolic rate or mitochondrial function. Malnutrition in early life has been linked to an increased likelihood to develop and an exacerbation of metabolic syndrome, however fish that were calorically restricted from five days after fertilization until three to nine months of age did not show signs of an exacerbated phenotype. In contrast, the groups that were shifted later in life from caloric restriction to the obesogenic environment did not completely catch up to the long-term obesity group by the end of our experiment. This dataset provides insight into a slowly exacerbating time-course of obesity phenotypes.
C1 [Leibold, Sandra; Lakshminarasimha, Amrutha Bagivalu; Hammerschmidt, Matthias; Michel, Maximilian] Univ Cologne, Inst Zool, Cologne, Germany.
   [Leibold, Sandra; Hammerschmidt, Matthias] Univ Cologne, Cologne Excellence Cluster Cellular Stress Respon, Cologne, Germany.
   [Gremse, Felix] Rhein Westfal TH Aachen, Fac Med, Inst Expt Mol Imaging, Dept Nanomed & Theranost, Aachen, Germany.
   [Gremse, Felix] Gremse IT GmbH, Aachen, Germany.
   [Hammerschmidt, Matthias] Univ Cologne, Ctr Mol Med Cologne, Cologne, Germany.
C3 University of Cologne; University of Cologne; RWTH Aachen University;
   University of Cologne
RP Michel, M (corresponding author), Univ Cologne, Inst Zool, Cologne, Germany.
EM maximichel@gmail.com
RI Michel, Maximilian/A-8079-2012
OI Michel, Maximilian/0000-0002-5910-5363; Bagivalu Lakshminarasimha,
   Amrutha/0000-0002-5742-4360
CR Ali M, 2003, FISH FISH, V4, P147, DOI 10.1046/j.1467-2979.2003.00120.x
   Baird J, 2005, BMJ-BRIT MED J, V331, P929, DOI 10.1136/bmj.38586.411273.E0
   BEAMISH FWH, 1974, J FISH RES BOARD CAN, V31, P1763, DOI 10.1139/f74-224
   Blaxter KL., 1989, ENERGY METABOLISM AN
   Boersma B, 1997, ENDOCR REV, V18, P646, DOI 10.1210/er.18.5.646
   Brand Michael, 2002, P7
   Buscemi S, 2007, CLIN NUTR, V26, P806, DOI 10.1016/j.clnu.2007.08.010
   Chen JH, 2005, DNA REPAIR, V4, P1140, DOI 10.1016/j.dnarep.2005.06.003
   Chen WT, 2013, MOL REPROD DEV, V80, P384, DOI 10.1002/mrd.22172
   Chiavaroli V, 2009, PEDIATRICS, V124, P695, DOI 10.1542/peds.2008-3056
   Corrigan JK, 2020, ELIFE, V9, DOI 10.7554/eLife.53560
   Cruz SA, 2010, COMP BIOCHEM PHYS A, V156, P190, DOI 10.1016/j.cbpa.2010.01.019
   DALL W, 1986, J EXP MAR BIOL ECOL, V96, P57, DOI 10.1016/0022-0981(86)90013-4
   Dearden L, 2015, FRONT NEUROENDOCRIN, V39, P3, DOI 10.1016/j.yfrne.2015.08.001
   Deck Courtney A, 2017, Front Endocrinol (Lausanne), V8, P63, DOI 10.3389/fendo.2017.00063
   Desai M, 2005, AM J PHYSIOL-REG I, V288, pR91, DOI 10.1152/ajpregu.00340.2004
   Desai M, 1996, BRIT J NUTR, V76, P591, DOI 10.1079/BJN19960065
   Diepenbroek M, 2014, INFORMATIK, V2014
   Dogan SA, 2014, CELL METAB, V19, P458, DOI 10.1016/j.cmet.2014.02.004
   DULLOO AG, 1993, AM J CLIN NUTR, V58, P614, DOI 10.1093/ajcn/58.5.614
   DULLOO AG, 1990, AM J CLIN NUTR, V52, P415, DOI 10.1093/ajcn/52.3.415
   Eames SC, 2010, ZEBRAFISH, V7, P205, DOI 10.1089/zeb.2009.0640
   Fernández-Silva P, 2007, METHOD CELL BIOL, V80, P571, DOI 10.1016/S0091-679X(06)80028-2
   Fernández-Verdejo R, 2019, NAT METHODS, V16, P797, DOI 10.1038/s41592-019-0513-9
   Ferrannini E, 2007, J CLIN ENDOCR METAB, V92, P396, DOI 10.1210/jc.2006-0944
   Forn-Cuni G, 2015, J ENDOCRINOL, V224, P159, DOI 10.1530/JOE-14-0398
   Froese R, 2006, J APPL ICHTHYOL, V22, P241, DOI 10.1111/j.1439-0426.2006.00805.x
   FRY FEJ, 1948, BIOL BULL-US, V94, P66, DOI 10.2307/1538211
   Gremse F, 2016, THERANOSTICS, V6, P328, DOI 10.7150/thno.13624
   Hammarstedt A, 2018, PHYSIOL REV, V98, P1911, DOI 10.1152/physrev.00034.2017
   He JL, 2021, J ENDOCRINOL, V249, P125, DOI 10.1530/JOE-20-0437
   Hector KL, 2012, J ZOOL, V286, P93, DOI 10.1111/j.1469-7998.2011.00850.x
   Hopkins Kevin D., 1992, Journal of the World Aquaculture Society, V23, P173, DOI 10.1111/j.1749-7345.1992.tb00766.x
   Howarth DL, 2011, ALCOHOL CLIN EXP RES, V35, P826, DOI 10.1111/j.1530-0277.2010.01407.x
   Huang YX, 2015, BMC GENOMICS, V16, DOI 10.1186/s12864-015-1654-6
   Jia JR, 2018, BIOCHEM BIOPH RES CO, V499, P285, DOI 10.1016/j.bbrc.2018.03.149
   Jimenez-Chillaron Josep C, 2007, Curr Opin Endocrinol Diabetes Obes, V14, P23, DOI 10.1097/MED.0b013e328013da8e
   JOBLING M, 1981, J FISH BIOL, V18, P385, DOI 10.1111/j.1095-8649.1981.tb03780.x
   Jobling M, 2010, AQUACULT INT, V18, P501, DOI 10.1007/s10499-009-9260-8
   Kahn R, 2005, DIABETES CARE, V28, P2289, DOI 10.2337/diacare.28.9.2289
   Kerkhof GF, 2012, J CLIN ENDOCR METAB, V97, P4498, DOI 10.1210/jc.2012-1716
   Koliaki C, 2016, ANNU REV NUTR, V36, P337, DOI 10.1146/annurev-nutr-071715-050656
   Landgraf Kathrin, 2017, BMC Physiology, V17, DOI 10.1186/s12899-017-0031-x
   Landsberg L, 2012, OBES REV, V13, P97, DOI 10.1111/j.1467-789X.2012.01040.x
   Landsberg Lewis, 2009, Trans Am Clin Climatol Assoc, V120, P287
   Leibold S, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0120776
   Lippert RN, 2022, BIOL PSYCHIAT, V91, P898, DOI 10.1016/j.biopsych.2021.06.002
   Löhr H, 2018, CELL REP, V23, P1728, DOI 10.1016/j.celrep.2018.04.018
   London S, 2019, GEN COMP ENDOCR, V282, DOI 10.1016/j.ygcen.2019.06.011
   LUCAS MC, 1992, J FISH BIOL, V41, P175, DOI 10.1111/j.1095-8649.1992.tb02648.x
   Maddison LA, 2017, FRONT ENDOCRINOL, V8, DOI 10.3389/fendo.2017.00009
   McBride RS, 2015, FISH FISH, V16, P23, DOI 10.1111/faf.12043
   Meguro S, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-53634-z
   Meguro S, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0120142
   Mehta NM, 2013, JPEN-PARENTER ENTER, V37, P460, DOI 10.1177/0148607113479972
   MERSMANN HJ, 1987, J ANIM SCI, V64, P752, DOI 10.2527/jas1987.643752x
   Metcalfe NB, 2003, EXP GERONTOL, V38, P935, DOI 10.1016/S0531-5565(03)00159-1
   Monteiro POA, 2005, OBES REV, V6, P143, DOI 10.1111/j.1467-789X.2005.00183.x
   Norin T, 2011, J EXP BIOL, V214, P1668, DOI 10.1242/jeb.054205
   Oka Takehiko, 2010, BMC Physiol, V10, P21, DOI 10.1186/1472-6793-10-21
   Priede I.G., 1985, P33
   Radder RS, 2007, J EXP ZOOL PART A, V307A, P500, DOI 10.1002/jez.403
   Radulovic Stamen, 2021, IOP Conference Series: Earth and Environmental Science, DOI 10.1088/1755-1315/854/1/012076
   Ronnestad I, 2017, FRONT ENDOCRINOL, V8, DOI 10.3389/fendo.2017.00073
   Ryan W. J., 1990, Nutrition Abstracts and Reviews. Series B. Livestock Feeds and Feeding, V60, P653
   Sadler NC, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0047996
   Schlegel A, 2016, FRONT ENDOCRINOL, V7, DOI 10.3389/fendo.2016.00159
   Schlegel A, 2012, CELL MOL LIFE SCI, V69, P3953, DOI 10.1007/s00018-012-1037-y
   Schöttl T, 2020, OBESITY, V28, P590, DOI 10.1002/oby.22737
   Schöttl T, 2015, MOL METAB, V4, P631, DOI 10.1016/j.molmet.2015.07.001
   SHERIDAN MA, 1988, COMP BIOCHEM PHYS B, V90, P679, DOI 10.1016/0305-0491(88)90322-7
   Silventoinen K, 2016, AM J CLIN NUTR, V104, P371, DOI 10.3945/ajcn.116.130252
   Soares MJ, 2011, DIABETES METAB SYND, V5, P98, DOI 10.1016/j.dsx.2012.03.003
   Song Y, 2003, ENDOCRINE, V22, P257, DOI 10.1385/ENDO:22:3:257
   Song Y, 2007, FASEB J, V21, P2042, DOI 10.1096/fj.06-7503com
   STEFFENSEN JF, 1989, FISH PHYSIOL BIOCHEM, V6, P49, DOI 10.1007/BF02995809
   Thureen PJ, 2007, J PEDIATR GASTR NUTR, V45, pS152, DOI 10.1097/01.mpg.0000302962.08794.62
   Tschöp MH, 2012, NAT METHODS, V9, P57, DOI [10.1038/NMETH.1806, 10.1038/nmeth.1806]
   Türkoglu M, 2022, EAT WEIGHT DISORD-ST, V27, P163, DOI 10.1007/s40519-021-01140-5
   Turola E, 2015, DIS MODEL MECH, V8, P1037, DOI 10.1242/dmm.019950
   van der Klaauw AA, 2019, CELL, V176, P729, DOI 10.1016/j.cell.2018.12.009
   Voerman E, 2019, PLOS MED, V16, DOI 10.1371/journal.pmed.1002744
   Wang GY, 2014, JAMA-J AM MED ASSOC, V311, P587, DOI 10.1001/jama.2014.1
   Westerfield M., 2000, A Guide for the Laboratory Use of Zebrafish (Danio rerio). The Zebrafish Book Eugene: (4th editor), V4th
   Won Eugene T, 2013, Front Endocrinol (Lausanne), V4, P74, DOI 10.3389/fendo.2013.00074
   Xu CX, 2014, SPRINGERPLUS, V3, DOI 10.1186/2193-1801-3-687
   Yang P, 2019, EXP GERONTOL, V127, DOI 10.1016/j.exger.2019.110720
   Yeung MY, 2006, ACTA PAEDIATR, V95, P909, DOI 10.1080/08035250600724507
   Zang LQ, 2018, FRONT CELL DEV BIOL, V6, DOI 10.3389/fcell.2018.00091
   Zang LQ, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-01432-w
NR 90
TC 4
Z9 4
U1 0
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 11
PY 2022
VL 17
IS 5
AR e0267933
DI 10.1371/journal.pone.0267933
PG 24
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 2O1VP
UT WOS:000818854500040
PM 35544474
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Al Asoom, LI
AF Al Asoom, Lubna Ibrahim
TI The Association of Adiposity Indices and Plasma Vitamin D in Young
   Females in Saudi Arabia
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID BODY-MASS INDEX; PARATHYROID-HORMONE; 25-HYDROXYVITAMIN D; METABOLIC
   SYNDROME; HYPOVITAMINOSIS-D; ADOLESCENTS; POPULATION; MARKERS; HEALTH
AB Background. Vitamin D deficiency is a global health problem. Some evidences indicate its association with metabolic syndrome, type II diabetes, and cardiovascular diseases. In the current study we aim to study the association of vitamin D level and indicators of adiposity in young Saudi females. Subjects and Methods. 87 young healthy Saudi females were recruited from University of Dammam, Dammam, Saudi Arabia. Each subject filled vitamin D questionnaire and had exercise stress test to determine VO2 peak. Body weight, BMI, waist and hip circumference, and ratios were determined. Blood was analyzed for 25-OH vitamin D, glucose, triglycerides, total cholesterol, and differential cholesterol. Results. 25-OH vitamin D/body weight was negatively associated with waist circumference and waist/stature ratio. No significant difference was found between the groups of BMI with regard to the data of questionnaire or 25-OH vitamin D/body weight. Obese and overweight subjects had lower VO2 peak. Conclusion. In young Saudi females we found that the relative value of vitamin D to body weight is a better indicator of vitamin D status particularly in obese subjects and it is negatively associated with adiposity measures of waist circumference and waist/stature ratio.
C1 [Al Asoom, Lubna Ibrahim] Univ Dammam UOD, Coll Med, Dept Physiol, POB 1982, Dammam 31441, Saudi Arabia.
C3 Imam Abdulrahman Bin Faisal University
RP Al Asoom, LI (corresponding author), Univ Dammam UOD, Coll Med, Dept Physiol, POB 1982, Dammam 31441, Saudi Arabia.
EM lasoom@uod.edu.sa
RI Asoom, Lubna/V-2977-2019; Al-Asoom, Lubna/A-3233-2015
OI Al-Asoom, Lubna/0000-0002-0371-2367
FU Deanship of Scientific Research at University of Dammam, Dammam, Saudi
   Arabia [2013183]
FX The author would like to thank her medical students: Dina Al Afandi,
   Leena Abu Ghararah, Deema Sallut, and Alanoud Althkair for their help in
   vitamin D questionnaire preparation. The project was executed by Grant
   no. 2013183 provided by the Deanship of Scientific Research at
   University of Dammam, Dammam, Saudi Arabia.
CR Al-Daghri N. M., 2016, J STEROID BIOCH MOL
   Al-Daghri NM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0102141
   Al-Elq AH, 2009, SAUDI MED J, V30, P1542
   Alemzadeh R, 2008, METABOLISM, V57, P183, DOI 10.1016/j.metabol.2007.08.023
   Alsuwaida AO, 2013, SAUDI MED J, V34, P814
   Bolek-Berquist J, 2009, PUBLIC HEALTH NUTR, V12, P236, DOI 10.1017/S136898000800356X
   Boonchaya-anant P, 2014, OBESITY, V22, P2539, DOI 10.1002/oby.20877
   Borradale D, 2009, NUTR RES REV, V22, P118, DOI 10.1017/S0954422409990102
   Chu MP, 2010, POSTGRAD MED J, V86, P608, DOI 10.1136/pgmj.2010.101121
   Forney LA, 2014, J STRENGTH COND RES, V28, P814, DOI 10.1519/JSC.0b013e3182a35ed0
   FROELICHER VF, 1975, CHEST, V68, P331, DOI 10.1378/chest.68.3.331
   Gilsanz V, 2010, J CLIN ENDOCR METAB, V95, P1595, DOI 10.1210/jc.2009-2309
   González-Gross M, 2012, BRIT J NUTR, V107, P755, DOI 10.1017/S0007114511003527
   Hjelmesaeth Joran, 2009, Cardiovasc Diabetol, V8, P7, DOI 10.1186/1475-2840-8-7
   Hussain AN, 2014, ARCH OSTEOPOROS, V9, DOI 10.1007/s11657-014-0190-3
   Kolokotroni O, 2015, PUBLIC HEALTH NUTR, V18, P112, DOI 10.1017/S1368980013003480
   Kremer R, 2009, J CLIN ENDOCR METAB, V94, P67, DOI 10.1210/jc.2008-1575
   Lagunova Z, 2009, ANTICANCER RES, V29, P3713, DOI 10.14341/2071-8713-4886
   Lips P, 2006, PROG BIOPHYS MOL BIO, V92, P4, DOI 10.1016/j.pbiomolbio.2006.02.016
   Lips P, 2010, J STEROID BIOCHEM, V121, P297, DOI 10.1016/j.jsbmb.2010.02.021
   Maetani M, 2009, NUTR CANCER, V61, P225, DOI 10.1080/01635580802455149
   McGill AT, 2008, NUTR J, V7, DOI 10.1186/1475-2891-7-4
   Moan J, 2009, J STEROID BIOCHEM, V113, P217, DOI 10.1016/j.jsbmb.2009.01.001
   Naeem Z, 2011, INT J HEALTH SCI-IJH, V5, P116
   Peterson CA, 2014, THER ADV ENDOCRINOL, V5, P166, DOI 10.1177/2042018814547205
   POLLOCK ML, 1982, AM HEART J, V103, P363, DOI 10.1016/0002-8703(82)90275-7
   Pourshahidi LK, 2015, P NUTR SOC, V74, P115, DOI 10.1017/S0029665114001578
   Saadi HF, 2006, BONE, V39, P1136, DOI 10.1016/j.bone.2006.05.010
   Sadat-Ali M, 2014, SAUDI MED J, V35, P1243
   World Med Assoc, 2013, JAMA-J AM MED ASSOC, V310, P2191, DOI 10.1001/jama.2013.281053
NR 30
TC 8
Z9 9
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2016
VL 2016
AR 1215362
DI 10.1155/2016/1215362
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DS9VC
UT WOS:000381130600001
PM 27525007
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kelley, DS
   Adkins, YC
   Zunino, SJ
   Woodhouse, LR
   Bonnel, EL
   Breksa, AP
   Manners, GD
   Mackey, BE
AF Kelley, Darshan S.
   Adkins, Yuriko C.
   Zunino, Susan J.
   Woodhouse, Leslie R.
   Bonnel, Ellen L.
   Breksa, Andrew P., III
   Manners, Gary D.
   Mackey, Bruce E.
TI Citrus limonin glucoside supplementation decreased biomarkers of liver
   disease and inflammation in overweight human adults
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Liver enzymes; Metabolic syndrome; Nonalcoholic fatty liver disease;
   Cardiovascular disease; Obesity; Inflammation
ID GAMMA-GLUTAMYL-TRANSFERASE; HIGH-FAT DIET; SERUM ALANINE
   AMINOTRANSFERASE; INDUCED OBESE MICE; ORANGE JUICE;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; DRUG-RESISTANCE;
   UNITED-STATES; CANCER-CELLS
AB Mixtures of limonoid glucosides demonstrated health benefits in human and animal studies; however, the specific metabolic effects of purified citrus limonin glucoside (LG) in humans are unknown. We determined effects of LG on circulating biomarkers of chronic inflammatory diseases such as nonalcoholic fatty liver disease (NAFLD), diabetes, CVD, and cancer in a cross-over, placebo controlled, double-blind study in overweight/obese individuals. LG had no specific adverse effects. It did not alter circulating concentrations of blood lipids, lipoproteins or their particle sizes, glucose, insulin, hematological parameters, and markers of inflammation except MMP-9 and TNF-alpha which were decreased by 38.7% and 10.7%, respectively. LG significantly decreased concentrations of liver proteins: gamma-glutamyl transferase (33.8%), alanine aminotransferase (13.1%), alkaline phosphatase (10.1%), and complement C3 (6.4%). Since liver enzymes are elevated in metabolic syndrome, NAFLD, diabetes, CVD, and chronic kidney disease and liver cancer, LG may be useful in the prevention and/or treatment of those diseases. Published by Elsevier Ltd.
C1 [Kelley, Darshan S.; Adkins, Yuriko C.; Zunino, Susan J.; Woodhouse, Leslie R.; Bonnel, Ellen L.] USDA ARS, Western Human Nutr Res Ctr, Davis, CA 95616 USA.
   [Kelley, Darshan S.; Adkins, Yuriko C.; Zunino, Susan J.; Woodhouse, Leslie R.; Bonnel, Ellen L.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Breksa, Andrew P., III; Manners, Gary D.; Mackey, Bruce E.] USDA, ARS, Western Reg Res Ctr, Albany, CA 94710 USA.
C3 United States Department of Agriculture (USDA); University of California
   System; University of California Davis; United States Department of
   Agriculture (USDA)
RP Kelley, DS (corresponding author), USDA ARS, Western Human Nutr Res Ctr, 430 West Hlth Sci Dr, Davis, CA 95616 USA.
EM darshan.kelley@ars.usda.gov
OI Breksa, Andrew/0000-0002-7472-7849; Adkins, Yuriko/0000-0002-5705-5964
FU U.S. Department of Agriculture, Agricultural Research Service
   [5306-51530-017-00D, 2030-41430-011-00D]; Coca-Cola Company, 1 Coca-Cola
   Plaza, Atlanta, USA
FX Supported in part by the U.S. Department of Agriculture, Agricultural
   Research Service (CRIS # 5306-51530-017-00D and CRIS #
   2030-41430-011-00D) and The Coca-Cola Company, 1 Coca-Cola Plaza,
   Atlanta, GA 30313 USA.
CR Aptekmann NP, 2010, MATURITAS, V67, P343, DOI 10.1016/j.maturitas.2010.07.009
   Bo S, 2005, WORLD J GASTROENTERO, V11, P7109, DOI 10.3748/wjg.v11.i45.7109
   Breksa AP, 2008, J AGR FOOD CHEM, V56, P5595, DOI 10.1021/jf800473z
   Breksa AP, 2009, FOOD CHEM, V113, P1308, DOI 10.1016/j.foodchem.2008.08.046
   Buscemi S, 2012, AM J CLIN NUTR, V95, P1089, DOI 10.3945/ajcn.111.031088
   Cesar TB, 2010, NUTR RES, V30, P689, DOI 10.1016/j.nutres.2010.09.006
   Chen Z, 2014, DIGEST DIS SCI, V59, P2470, DOI 10.1007/s10620-014-3214-3
   Corti A, 2010, ANTICANCER RES, V30, P1169
   Dalgård C, 2009, BRIT J NUTR, V101, P263, DOI 10.1017/S0007114508995660
   Daniel S, 1999, AM J GASTROENTEROL, V94, P3010, DOI 10.1111/j.1572-0241.1999.01451.x
   Demonty I, 2010, J NUTR, V140, P1615, DOI 10.3945/jn.110.124735
   Deopurkar R, 2010, DIABETES CARE, V33, P991, DOI 10.2337/dc09-1630
   Devaraj S, 2004, ARTERIOSCL THROM VAS, V24, pE25, DOI 10.1161/01.ATV.0000120784.08823.99
   Díaz-Juárez JA, 2009, PHYTOTHER RES, V23, P948, DOI 10.1002/ptr.2680
   Dugdale D., 2012, NATL LIB MED MEDLINE
   Fishbein MH, 2003, J PEDIATR GASTR NUTR, V36, P54, DOI 10.1097/00005176-200301000-00012
   FONG CH, 1993, J AGR FOOD CHEM, V41, P112, DOI 10.1021/jf00025a024
   Ghanim H, 2010, AM J CLIN NUTR, V91, P940, DOI 10.3945/ajcn.2009.28584
   Ghouri N, 2010, HEPATOLOGY, V52, P1156, DOI 10.1002/hep.23789
   Green CO, 2013, FOOD CHEM TOXICOL, V51, P306, DOI 10.1016/j.fct.2012.10.005
   Guthrie N., 2000, Citrus limonoids, P164
   Ioannou GN, 2006, AM J GASTROENTEROL, V101, P76, DOI 10.1111/j.1572-0241.2005.00341.x
   Joshipura KJ, 2001, ANN INTERN MED, V134, P1106, DOI 10.7326/0003-4819-134-12-200106190-00010
   Kang SI, 2012, BIOL PHARM BULL, V35, P223, DOI 10.1248/bpb.35.223
   Kazemi-Shirazi L, 2007, CLIN CHEM, V53, P940, DOI 10.1373/clinchem.2006.081620
   Kelley DS, 2007, AM J CLIN NUTR, V86, P324, DOI 10.1093/ajcn/86.2.324
   Kelley DS, 2013, J NUTR, V143, P340, DOI 10.3945/jn.112.171371
   Kim J, 2013, FOOD FUNCT, V4, P258, DOI 10.1039/c2fo30209h
   Kris-Etherton Penny M., 2002, American Journal of Medicine, V113, p71S, DOI 10.1016/S0002-9343(01)00995-0
   Kurowska EM, 2000, AM J CLIN NUTR, V72, P1095
   Lee YS, 2011, PHYTOMEDICINE, V18, P648, DOI 10.1016/j.phymed.2010.11.005
   Littell R.C., 2006, SAS SYSTEM MIXED MOD
   Manners GD, 2007, J AGR FOOD CHEM, V55, P8285, DOI 10.1021/jf071797h
   Manners GD, 2003, J AGR FOOD CHEM, V51, P4156, DOI 10.1021/jf0300691
   Martí N, 2009, NAT PROD COMMUN, V4, P677
   Miller E. G., 2000, CITRUS LIMONOIDS INC
   Mistry D, 2010, COPD, V7, P285, DOI 10.3109/15412555.2010.496819
   Mjiier V.P., 1977, Citrus Science and Technology, P355
   Ness AR, 1997, INT J EPIDEMIOL, V26, P1, DOI 10.1093/ije/26.1.1
   Oh HJ., 2011, KOREAN J HEPATOL, V17, DOI 10.3350/kjhep.2011.17.1.27
   Oh RC, 2011, AM FAM PHYSICIAN, V84, P1003
   Ono E, 2011, BIOCHEM BIOPH RES CO, V410, P677, DOI 10.1016/j.bbrc.2011.06.055
   OZAKI Y, 1995, J FOOD SCI, V60, P186, DOI 10.1111/j.1365-2621.1995.tb05634.x
   Park HJ, 2013, J NUTR BIOCHEM, V24, P419, DOI 10.1016/j.jnutbio.2011.12.009
   Pompella A, 2004, CLIN CHEM LAB MED, V42, P1085, DOI 10.1515/CCLM.2004.224
   Pompella A, 2007, CURR OPIN PHARMACOL, V7, P360, DOI 10.1016/j.coph.2007.04.004
   Raasmaja A, 2013, FOOD CHEM, V138, P1392, DOI 10.1016/j.foodchem.2012.09.140
   Robertson L, 2007, J INTERN MED, V262, P659, DOI 10.1111/j.1365-2796.2007.01861.x
   Roomi MW, 2006, EXP MOL PATHOL, V81, P8, DOI 10.1016/j.yexmp.2006.02.006
   Ruhl CE, 2009, GASTROENTEROLOGY, V136, P477, DOI 10.1053/j.gastro.2008.10.052
   Salamone F, 2012, WORLD J GASTROENTERO, V18, P3862, DOI 10.3748/wjg.v18.i29.3862
   Strasak AM, 2008, CANCER RES, V68, P3970, DOI 10.1158/0008-5472.CAN-07-6686
   Targher G, 2010, CLIN CHEM LAB MED, V48, P147, DOI 10.1515/CCLM.2010.031
   Titta L, 2010, INT J OBESITY, V34, P578, DOI 10.1038/ijo.2009.266
   Toh JY, 2013, CURR ATHEROSCLER REP, V15, DOI 10.1007/s11883-013-0368-y
   Tsujita T, 2007, J NUTR SCI VITAMINOL, V53, P547, DOI 10.3177/jnsv.53.547
   Tundis R, 2014, CRIT REV FOOD SCI, V54, P225, DOI 10.1080/10408398.2011.581400
   Wen CP, 2012, J NATL CANCER I, V104, P1599, DOI 10.1093/jnci/djs372
   Yamada J, 2006, ATHEROSCLEROSIS, V189, P198, DOI 10.1016/j.atherosclerosis.2005.11.036
   Yin X, 2013, EUR J GASTROEN HEPAT, V25, P1408, DOI 10.1097/MEG.0b013e328364130f
NR 60
TC 27
Z9 28
U1 0
U2 32
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JAN
PY 2015
VL 12
BP 271
EP 281
DI 10.1016/j.jff.2014.11.026
PG 11
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA CB3CG
UT WOS:000349505200028
OA hybrid
DA 2025-06-11
ER

PT J
AU Renna, NF
   Diez, EA
   Miatello, RM
AF Renna, Nicolas F.
   Diez, Emiliano A.
   Miatello, Roberto M.
TI Effects of Dipeptidyl-Peptidase 4 Inhibitor about Vascular Inflammation
   in a Metabolic Syndrome Model
SO PLOS ONE
LA English
DT Article
ID GLUCAGON-LIKE PEPTIDE-1; ENDOTHELIAL FUNCTION; RELAXATION; RECEPTOR;
   GLUCOSE; MUSCLE; ARTERY; GLP-1; DPP-4
AB Background: In this study, we used vidagliptin(V) to examine the role of the DDP-IV, incretin system component, in the activation of different molecular inflammatory cytokines, NF-kB and VCAM-1 to generate a microenvironment that supports cardiovascular remodeling.
   Methods: Male WKY and SHR were separated into five groups: Control, FFR: WKY rats receiving a 10% (w/v) fructose solution during all 12 weeks, SHR, FFHR: SHR receiving a 10% (w/v) fructose solution during all 12 weeks and FFHR+V: (5 mg/kg per day for 6 weeks) (n = 8 each group). Metabolic variables and systolic blood pressure were measured. The TBRAS, eNOS activity, and NAD(P) H oxidase activity were estimated to evaluate oxidative stress. Cardiac and vascular remodeling were evaluated. To assess the cytokine, NF-kB and VCAM-1 immunostaining techniques were used.
   Results: The FFHR experimental model presents metabolic syndrome criteria, vascular and cardiac remodeling, vascular inflammation due to increased expression of NF-kB, VCAM-1, and pro-atherogenic cytokines. Chronic treatment with V was able to reverse total or partiality of variables studied.
   Conclusions: Data demonstrated an important effect of DDP-IV in reducing vascular inflammation, accompanied by a favorable reduction in metabolic and structural parameters.
C1 [Renna, Nicolas F.; Miatello, Roberto M.] Natl Univ Cuyo, Sch Med, Dept Pathol, Mendoza, Argentina.
   [Renna, Nicolas F.; Diez, Emiliano A.; Miatello, Roberto M.] Consejo Nacl Invest Cient & Tecn, Lab Cardiovasc Physiopathol, Inst Expt Med & Biol Cuyo IMBECU, Mendoza, Argentina.
C3 University Nacional Cuyo Mendoza; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Instituto de Medicina y BiologIa
   Experimental de Cuyo (IMBECU)
RP Renna, NF (corresponding author), Natl Univ Cuyo, Sch Med, Dept Pathol, Mendoza, Argentina.
EM nicolasrenna@fcm.uncu.edu.ar
RI Diez, Emiliano/KIB-2439-2024
OI Diez, Emiliano/0000-0001-5163-3703
FU Consejo Nacional de Investigaciones Cientificas y Tecnicas
FX This work was supported by Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (http://www.conicet.gov.ar). The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
CR Ahrén B, 2004, J CLIN ENDOCR METAB, V89, P2078, DOI 10.1210/jc.2003-031907
   [Anonymous], AM J PHYSL ENDOCRINO
   Ban K, 2008, CIRCULATION, V117, P2340, DOI 10.1161/CIRCULATIONAHA.107.739938
   Barnett A, 2006, INT J CLIN PRACT, V60, P1454, DOI 10.1111/j.1742-1241.2006.01178.x
   Basu A, 2007, AM J PHYSIOL-ENDOC M, V293, pE1289, DOI 10.1152/ajpendo.00373.2007
   Carretero OA, 2000, CIRCULATION, V101, P329, DOI 10.1161/01.CIR.101.3.329
   Dong AL, 2011, P NATL ACAD SCI USA, V108, P14614, DOI 10.1073/pnas.1012859108
   Drucker DJ, 2006, LANCET, V368, P1696, DOI 10.1016/S0140-6736(06)69705-5
   Fleming I, 1999, CARDIOVASC RES, V43, P532, DOI 10.1016/S0008-6363(99)00094-2
   FURCHGOTT RF, 1980, NATURE, V288, P373, DOI 10.1038/288373a0
   IGNARRO LJ, 1987, CIRC RES, V61, P866, DOI 10.1161/01.RES.61.6.866
   KEANEY JF, 1993, P NATL ACAD SCI USA, V90, P11880, DOI 10.1073/pnas.90.24.11880
   Michel JB, 1997, J BIOL CHEM, V272, P25907, DOI 10.1074/jbc.272.41.25907
   Muniyappa R, 2007, ENDOCR REV, V28, P463, DOI 10.1210/er.2007-0006
   Nikolaidis LA, 2004, CIRCULATION, V109, P962, DOI 10.1161/01.CIR.0000120505.91348.58
   Nyström T, 2004, AM J PHYSIOL-ENDOC M, V287, pE1209, DOI 10.1152/ajpendo.00237.2004
   Panchapakesan U, 2013, CLIN SCI, V124, P17, DOI 10.1042/CS20120167
   Peairs AD, 2011, NUTR J, V10, DOI 10.1186/1475-2891-10-122
   Renna N, 2012, HDB METABOLIC SYNDRO
   Renna N F, 2013, Int J Hypertens, V2013, P420979, DOI 10.1155/2013/420979
   Renna Nicolas F, 2013, Int J Hypertens, V2013, P808353, DOI 10.1155/2013/808353
   Renna NF, 2013, MEDIAT INFLAMM, V2013, DOI 10.1155/2013/513251
   Renna NF, 2009, CLIN EXP PHARMACOL P, V36, P162, DOI 10.1111/j.1440-1681.2008.05042.x
   Shah Z, 2011, CIRCULATION, V124, P2339, DOI 10.1161/CIRCULATIONAHA.111.041418
   Siegel David, 2007, Metabolic Syndrome and Related Disorders, V5, P211, DOI 10.1089/met.2007.0016
   Ussher JR, 2012, ENDOCR REV, V33, P187, DOI 10.1210/er.2011-1052
   Valerio A, 2006, J CLIN INVEST, V116, P2791, DOI [10.1172/JCI28570, 10.1172/JCI28570.]
   Vilsboll T, 2003, J CLIN ENDOCR METAB, V88, P4897, DOI 10.1210/jc.2003-030738
   Vomhof-DeKrey EE, 2012, FREE RADICAL BIO MED, V53, P690, DOI 10.1016/j.freeradbiomed.2012.05.047
NR 29
TC 10
Z9 10
U1 0
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 3
PY 2014
VL 9
IS 9
AR e106563
DI 10.1371/journal.pone.0106563
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AO3TB
UT WOS:000341257700088
PM 25184237
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Corona, G
   Maggi, M
AF Corona, Giovanni
   Maggi, Mario
TI The role of testosterone in erectile dysfunction
SO NATURE REVIEWS UROLOGY
LA English
DT Review
ID LATE-ONSET HYPOGONADISM; DISTINCT ANIMAL-MODELS; NITRIC-OXIDE SYNTHASE;
   SEXUAL DYSFUNCTION; METABOLIC SYNDROME; DOUBLE-BLIND; STRUCTURED
   INTERVIEW; ANDROGEN REPLACEMENT; REVERSIBLE REDUCTION; PDE5 INHIBITORS
AB Erectile dysfunction (ED) is a clinical disorder that results from a continuous spectrum of clinical factors, including physical illness (comprising the organic component of ED), reaction to stress (the intrapsychic component of ED) and relationship difficulties (the relationship component of ED). Testosterone clearly has a relevant role in all three causes of ED; the usefulness of this hormone in the treatment of ED has not, however, been completely clarified. The main physiological action of testosterone in the male sexual response is to regulate the timing of the erectile process as a function of sexual desire, thereby coordinating penile erection with sex. The link between ED, hypogonadism and underlying disorders (such as metabolic syndrome and type 2 diabetes mellitus) is nowadays well documented. The recognition of underlying disorders might be useful in motivating men with ED to improve their health-related lifestyle choices. Hence, patients with ED might be considered 'lucky', because their disorder offers the opportunity to undergo medical examinations to detect underlying disease. Both ED and hypogonadism are treatable conditions. A range of testosterone preparations are available for supplementation; their combination with phosphodiesterase 5 inhibitors might improve outcomes in some cases.
C1 [Corona, Giovanni; Maggi, Mario] Univ Florence, Sexual Med & Androl Unit, Dept Clin Physiopathol, I-50139 Florence, Italy.
C3 University of Florence
RP Maggi, M (corresponding author), Univ Florence, Sexual Med & Androl Unit, Dept Clin Physiopathol, Viale Pieraccini 6, I-50139 Florence, Italy.
EM m.maggi@dfc.unifi.it
RI Maggi, Mario/AAB-8284-2019
OI MAGGI, Mario/0000-0003-3267-4221
CR ANDERSON RA, 1992, J CLIN ENDOCR METAB, V75, P1503, DOI 10.1210/jc.75.6.1503
   [Anonymous], 1970, NATURE, V226, P869, DOI 10.1038/226869a0
   Archer J, 2006, NEUROSCI BIOBEHAV R, V30, P319, DOI 10.1016/j.neubiorev.2004.12.007
   Aversa A, 2003, CLIN ENDOCRINOL, V58, P632, DOI 10.1046/j.1365-2265.2003.01764.x
   Bancroft J, 2005, J ENDOCRINOL, V186, P411, DOI 10.1677/joe.1.06233
   Bandini E, 2009, J SEX MED, V6, P2321, DOI 10.1111/j.1743-6109.2009.01322.x
   Behre H M., 2004, Testosterone: action, deficiency, substitution, V3rd edn, P405
   BELL RR, 1975, J MARRIAGE FAM, V37, P375, DOI 10.2307/350971
   Berridge MJ, 2008, J PHYSIOL-LONDON, V586, P5047, DOI 10.1113/jphysiol.2008.160440
   Bhasin S, 2007, LANCET, V369, P597, DOI 10.1016/S0140-6736(07)60280-3
   Bhasin S, 2006, J CLIN ENDOCR METAB, V91, P1995, DOI 10.1210/jc.2005-2847
   Boloña ER, 2007, MAYO CLIN PROC, V82, P20, DOI 10.4065/82.1.20
   Brüning JC, 2000, SCIENCE, V289, P2122, DOI 10.1126/science.289.5487.2122
   Burcelin R, 2003, ENDOCRINOLOGY, V144, P4484, DOI 10.1210/en.2003-0457
   Buvat J, 2009, EUR UROL SUPPL, V8, P214, DOI 10.1016/S1569-9056(09)60378-X
   Buvat J, 2003, INT J IMPOT RES, V15, P373, DOI 10.1038/sj.ijir.3901043
   Buvat J, 2006, WORLD J UROL, V24, P657, DOI 10.1007/s00345-006-0131-x
   CARANI C, 1990, ARCH SEX BEHAV, V19, P223, DOI 10.1007/BF01541548
   Carosa E, 2002, INT J IMPOT RES, V14, P93, DOI 10.1038/sj.ijir.3900832
   Carosa E, 2004, CLIN ENDOCRINOL, V61, P382, DOI 10.1111/j.1365-2265.2004.02108.x
   CARTER JN, 1978, NEW ENGL J MED, V299, P847, DOI 10.1056/NEJM197810192991602
   Cavallini G, 2004, UROLOGY, V63, P641, DOI 10.1016/j.urology.2003.11.009
   CHAMNESS SL, 1995, FERTIL STERIL, V63, P1101, DOI 10.1016/S0015-0282(16)57555-4
   Chatterjee R, 2004, J FAM PLAN REPROD H, V30, P88, DOI 10.1783/147118904322995438
   Ciccarelli Antonio, 2005, Pituitary, V8, P39, DOI 10.1007/s11102-005-5084-3
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Corona G, 2006, INT J IMPOT RES, V18, P190, DOI 10.1038/sj.ijir.3901391
   Corona G, 2005, INT J ANDROL, V28, P46, DOI 10.1111/j.1365-2605.2005.00594.x
   Corona G, 2004, INT J IMPOT RES, V16, P275, DOI 10.1038/sj.ijir.3901158
   Corona G, 2009, J MENS HEALTH, V6, P210, DOI 10.1016/j.jomh.2009.05.002
   Corona G, 2009, INT J ANDROL, V32, P587, DOI 10.1111/j.1365-2605.2008.00951.x
   Corona G, 2009, INT J ANDROL, V32, P720, DOI 10.1111/j.1365-2605.2009.00952.x
   Corona G, 2008, AGING MALE, V11, P193, DOI 10.1080/13685530802468497
   Corona G, 2007, J SEX MED, V4, P1485, DOI 10.1111/j.1743-6109.2007.00569.x
   Corona G, 2006, EUR UROL, V50, P595, DOI 10.1016/j.eururo.2006.02.053
   Corona G, 2006, J SEX MED, V3, P706, DOI 10.1111/j.1743-6109.2006.00262.x
   Corona G, 2010, J SEX MED, V7, P1362, DOI 10.1111/j.1743-6109.2009.01601.x
   Corona G, 2010, J SEX MED, V7, P182, DOI 10.1111/j.1743-6109.2009.01497.x
   Corona G, 2009, J SEX MED, V6, P2591, DOI 10.1111/j.1743-6109.2009.01352.x
   Dettenhofer MariaH., 2009, ROME CHINA COMP PERS, P83
   Dhindsa S, 2004, J CLIN ENDOCR METAB, V89, P5462, DOI 10.1210/jc.2004-0804
   Diaz-Arjonilla M, 2009, INT J IMPOT RES, V21, P89, DOI 10.1038/ijir.2008.42
   DROLLER MJ, 1993, JAMA-J AM MED ASSOC, V270, P83
   Ebert T, 2005, EUR UROL, V47, P137, DOI 10.1016/j.eururo.2004.09.015
   Edelstein D, 2007, EXPERT OPIN PHARMACO, V8, P2991, DOI 10.1517/14656566.8.17.2991
   FABBRI A, 1988, J CLIN ENDOCR METAB, V67, P867, DOI 10.1210/jcem-67-5-867
   Filippi S, 2009, J SEX MED, V6, P3274, DOI 10.1111/j.1743-6109.2009.01467.x
   Fisher AD, 2009, J SEX MED, V6, P866, DOI 10.1111/j.1743-6109.2008.01140.x
   Foresta C, 2004, J UROLOGY, V171, P2358, DOI 10.1097/01.ju.0000124323.02868.68
   Golden SH, 2009, J CLIN ENDOCR METAB, V94, P1853, DOI 10.1210/jc.2008-2291
   Greco EA, 2006, EUR UROL, V50, P940, DOI 10.1016/j.eururo.2006.06.049
   Greenstein A, 2005, J UROLOGY, V173, P530, DOI 10.1097/01.ju.0000149870.36577.05
   HARKAWAY RC, 2006, UROLOGY, V67, P571
   Heinemann L A J, 2004, Aging Male, V7, P211
   Hwang TIS, 2008, INT J IMPOT RES, V20, P231, DOI 10.1038/sj.ijir.3901633
   Hwang TIS, 2006, INT J IMPOT RES, V18, P400, DOI 10.1038/sj.ijir.3901446
   Isidori AM, 2005, CLIN ENDOCRINOL, V63, P381, DOI 10.1111/j.1365-2265.2005.02350.x
   Jain P, 2000, J UROLOGY, V164, P371, DOI 10.1016/S0022-5347(05)67363-6
   Jannini EA, 1999, INT J ANDROL, V22, P385, DOI 10.1046/j.1365-2605.1999.00196.x
   Kalinchenko S Y, 2003, Aging Male, V6, P94, DOI 10.1080/713604767
   Luboshitzky R, 2002, J CLIN ENDOCR METAB, V87, P3394, DOI 10.1210/jc.87.7.3394
   LUGG JA, 1995, ENDOCRINOLOGY, V136, P1495, DOI 10.1210/en.136.4.1495
   Mazur A, 1998, BEHAV BRAIN SCI, V21, P353, DOI 10.1017/S0140525X98001228
   McVary KT, 2007, NEW ENGL J MED, V357, P2472, DOI 10.1056/NEJMcp067261
   Mehta PH, 2008, J PERS SOC PSYCHOL, V94, P1078, DOI 10.1037/0022-3514.94.6.1078
   Morales A, 2004, J SEX MED, V1, P69, DOI 10.1111/j.1743-6109.2004.10111.x
   Morelli A, 2007, J ENDOCRINOL INVEST, V30, P880, DOI 10.1007/BF03349232
   Morelli A, 2004, ENDOCRINOLOGY, V145, P2253, DOI 10.1210/en.2003-1699
   Morley JE, 2006, MATURITAS, V53, P424, DOI 10.1016/j.maturitas.2005.07.004
   Morley JE, 2000, METABOLISM, V49, P1239, DOI 10.1053/meta.2000.8625
   O'Connor DB, 2004, J CLIN ENDOCR METAB, V89, P2837, DOI 10.1210/jc.2003-031354
   Park KH, 1999, BJU INT, V83, P327
   Petak Steven M, 2002, Endocr Pract, V8, P440
   Petrone L, 2003, INT J IMPOT RES, V15, P210, DOI 10.1038/sj.ijir.3901006
   Pfeil E, 2008, EXPERT OPIN DRUG DEL, V5, P471, DOI 10.1517/17425247.5.4.471 
   Qoubaitary A, 2005, EXPERT OPIN PHARMACO, V6, P1493, DOI 10.1517/14656566.6.9.1493
   Rhoden EL, 2002, J UROLOGY, V167, P1745, DOI 10.1016/S0022-5347(05)65191-9
   Rochira V, 2006, J ANDROL, V27, P165, DOI 10.2164/jandrol.05077
   Seftel A, 2007, INT J IMPOT RES, V19, P2, DOI 10.1038/sj.ijir.3901366
   Shabsigh R, 2004, J UROLOGY, V172, P658, DOI 10.1097/01.ju.0000132389.97804.d7
   Shamloul R, 2005, J SEX MED, V2, P559, DOI 10.1111/j.1743-6109.2005.00071.x
   SKAKKEBAEK NE, 1981, CLIN ENDOCRINOL, V14, P49, DOI 10.1111/j.1365-2265.1981.tb00364.x
   Smith KW, 2000, CLIN ENDOCRINOL, V53, P703, DOI 10.1046/j.1365-2265.2000.01152.x
   Steidle C, 2003, J CLIN ENDOCR METAB, V88, P2673, DOI 10.1210/jc.2002-021058
   Swaab DF, 2007, BEST PRACT RES CL EN, V21, P431, DOI 10.1016/j.beem.2007.04.003
   Tas A, 2006, INT J IMPOT RES, V18, P61, DOI 10.1038/sj.ijir.3901372
   Traish AM, 2009, J ANDROL, V30, P477, DOI 10.2164/jandrol.108.007245
   Traish AM, 2009, J ANDROL, V30, P10, DOI 10.2164/jandrol.108.005215
   Traish AM, 1999, ENDOCRINOLOGY, V140, P1861, DOI 10.1210/en.140.4.1861
   Traish AM, 2005, J ANDROL, V26, P242
   Treas J, 2000, J MARRIAGE FAM, V62, P48, DOI 10.1111/j.1741-3737.2000.00048.x
   van Anders SM, 2007, HORM BEHAV, V51, P454, DOI 10.1016/j.yhbeh.2007.01.002
   Vermeulen A, 1999, J CLIN ENDOCR METAB, V84, P3666, DOI 10.1210/jc.84.10.3666
   Vignozzi L, 2005, J Endocrinol Invest, V28, P39
   Vignozzi L, 2007, J SEX MED, V4, P620, DOI 10.1111/j.1743-6109.2007.00440.x
   Vignozzi L, 2009, J SEX MED, V6, P1270, DOI 10.1111/j.1743-6109.2008.01208.x
   Wang C, 2009, EUR UROL, V55, P121, DOI 10.1016/j.eururo.2008.08.033
   Wingard CJ, 2003, AM J PHYSIOL-REG I, V284, pR1572, DOI 10.1152/ajpregu.00041.2003
   Yassin AA, 2008, ANDROLOGIA, V40, P259, DOI 10.1111/j.1439-0272.2008.00851.x
   Yassin AA, 2006, ANDROLOGIA, V38, P61, DOI 10.1111/j.1439-0272.2006.00712.x
   Yassin AA, 2008, J ANDROL, V29, P593, DOI 10.2164/jandrol.107.004630
   Zhang XH, 2006, J SEX MED, V3, P253, DOI 10.1111/j.1743-6109.2006.00207.x
   Zhang XH, 2005, EUR UROL, V47, P409, DOI 10.1016/j.eururo.2004.10.021
NR 103
TC 121
Z9 138
U1 0
U2 21
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1759-4812
EI 1759-4820
J9 NAT REV UROL
JI Nat. Rev. Urol.
PD JAN
PY 2010
VL 7
IS 1
BP 46
EP 56
DI 10.1038/nrurol.2009.235
PG 11
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 542AD
UT WOS:000273462600007
PM 19997070
DA 2025-06-11
ER

PT J
AU González-Domínguez, A
   Domínguez-Riscart, J
   Savolainen, O
   Lechuga-Sancho, A
   Landberg, R
   González-Domínguez, R
AF Gonzalez-Dominguez, Alvaro
   Dominguez-Riscart, Jesus
   Savolainen, Otto
   Lechuga-Sancho, Alfonso
   Landberg, Rikard
   Gonzalez-Dominguez, Raul
TI Identifying metabotypes of insulin resistance severity in children with
   metabolic syndrome
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Insulin resistance; Childhood obesity; Metabolomics; Metabolic
   flexibility
ID OBESITY
AB BackgroundInsulin resistance is a frequent precursor of typical obesity and metabolic syndrome complications. However, accurate diagnosis remains elusive because of its pathophysiological complexity and heterogeneity. Herein, we have explored the utility of insulin secretion dynamics in response to an oral glucose tolerance test as a surrogate marker to identify distinct metabotypes of disease severity.MethodsThe study population consisted of children with obesity and insulin resistance, stratified according to the post-challenge insulin peak timing (i.e., early, middle, and late peak), from whom fasting and postprandial plasma and erythrocytes were collected for metabolomics analysis.ResultsChildren with late insulin peak manifested worse cardiometabolic health (i.e., higher blood pressure, glycemia, and HOMA-IR scores) than early responders. These subjects also showed more pronounced changes in metabolites mirroring failures in energy homeostasis, oxidative stress, metabolism of cholesterol and phospholipids, and adherence to unhealthy dietary habits. Furthermore, delayed insulin peak was associated with impaired metabolic flexibility, as reflected in compromised capacity to regulate mitochondrial energy pathways and the antioxidant defense in response to glucose overload.ConclusionsAltogether, these findings suggest that insulin resistance could encompass several phenotypic subtypes characterized by graded disturbances in distinctive metabolic derangements occurring in childhood obesity, which serve as severity predictive markers.
C1 [Gonzalez-Dominguez, Alvaro; Dominguez-Riscart, Jesus; Lechuga-Sancho, Alfonso; Gonzalez-Dominguez, Raul] Univ Cadiz, Hosp Univ Puerta Mar, Inst Invest Innovac Biomed Cadiz INiBICA, Cadiz 11009, Spain.
   [Gonzalez-Dominguez, Alvaro] Icahn Sch Med Mt Sinai, Div Liver Dis, New York, NY 10029 USA.
   [Dominguez-Riscart, Jesus; Lechuga-Sancho, Alfonso] Hosp Univ Puerta Mar, Serv Pediat, Unidad Endocrinol Pediat & Diabet, Cadiz 11009, Spain.
   [Savolainen, Otto; Landberg, Rikard] Chalmers Univ Technol, Dept Life Sci, Div Food & Nutr Sci, SE-41296 Gothenburg, Sweden.
   [Lechuga-Sancho, Alfonso] Univ Cadiz, Fac Med, Dept Materno Infantil & Radiol, Cadiz 11009, Spain.
C3 Universidad de Cadiz; Hospital Universitario Puerta del Mar; Icahn
   School of Medicine at Mount Sinai; Universidad de Cadiz; Hospital
   Universitario Puerta del Mar; Chalmers University of Technology;
   Universidad de Cadiz
RP González-Domínguez, R (corresponding author), Univ Cadiz, Hosp Univ Puerta Mar, Inst Invest Innovac Biomed Cadiz INiBICA, Cadiz 11009, Spain.
RI González-Domínguez, Raúl/E-5125-2016; González Domínguez,
   Álvaro/HJH-1098-2023; Lechuga-Sancho, Alfonso/M-2712-2015
OI Lechuga-Sancho, Alfonso/0000-0001-5861-6041
FU Universidad de Cadiz
FX Not applicable.
CR Altavilla C, 2019, PUBLIC HEALTH NUTR, V22, P2543, DOI 10.1017/S1368980019001058
   Blaise BJ, 2021, NAT PROTOC, V16, P4299, DOI 10.1038/s41596-021-00579-1
   Blazenovic I, 2018, METABOLITES, V8, DOI 10.3390/metabo8020031
   Boden G, 2008, ENDOCRIN METAB CLIN, V37, P635, DOI 10.1016/j.ecl.2008.06.007
   Castellano-Escuder P, 2020, DATABASE-OXFORD, DOI 10.1093/databa/baaa033
   Curley S, 2021, MOL NUTR FOOD RES, V65, DOI 10.1002/mnfr.201900482
   De Spiegeleer M, 2021, MOL MED, V27, DOI 10.1186/s10020-021-00394-0
   Elshorbagy AK, 2022, EUR J NUTR, V61, P3161, DOI 10.1007/s00394-022-02872-5
   Eyzaguirre F, 2009, HORM RES, V71, P65, DOI 10.1159/000183894
   Furuhashi M, 2020, AM J PHYSIOL-ENDOC M, V319, pE827, DOI 10.1152/ajpendo.00378.2020
   García-Carrasco A, 2021, NEPHRON, V145, P604, DOI 10.1159/000515419
   Giannini C, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.1011994
   González-Domínguez A, 2024, ANAL CHEM, V96, P1064, DOI 10.1021/acs.analchem.3c03660
   González-Domínguez A, 2024, BBA-MOL BASIS DIS, V1870, DOI 10.1016/j.bbadis.2023.166910
   González-Domínguez A, 2023, J TRANSL MED, V21, DOI 10.1186/s12967-023-04337-7
   González-Domínguez A, 2023, NUTRIENTS, V15, DOI 10.3390/nu15102347
   Gonzalez-Dominguez Alvaro, 2023, Methods Mol Biol, V2625, P79, DOI 10.1007/978-1-0716-2966-6_7
   Gonzalez-Dominguez Alvaro, 2023, Methods Mol Biol, V2571, P115, DOI 10.1007/978-1-0716-2699-3_11
   González-Domínguez A, 2018, CURR TOP MED CHEM, V18, P896, DOI 10.2174/1568026618666180711150525
   González-Domínguez R, 2020, J AGR FOOD CHEM, V68, P1851, DOI 10.1021/acs.jafc.8b07023
   Hayashi T, 2013, DIABETES CARE, V36, P1229, DOI 10.2337/dc12-0246
   Ho JE, 2013, DIABETES, V62, P2689, DOI 10.2337/db12-0754
   Holecek M, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24021724
   Jones C, 2021, PHYSIOL REP, V8, DOI 10.14814/phy2.14644
   Klavus A, 2020, METABOLITES, V10, DOI 10.3390/metabo10040135
   Lepine G, 2022, NUTRIENTS, V14, DOI 10.3390/nu14030472
   Martos-Moreno GA, 2019, PEDIATR OBES, V14, DOI 10.1111/ijpo.12565
   Murdolo G, 2013, BIOCHIMIE, V95, P585, DOI 10.1016/j.biochi.2012.12.014
   Panic A, 2022, Explor. Med, V3, P58, DOI [DOI 10.37349/EMED.2022.00074, 10.37349/emed.2022.00074]
   Picklo MJ, 2015, NUTR REV, V73, P858, DOI 10.1093/nutrit/nuv042
   Pietiläinen KH, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000218
   Racz Beata, 2015, Prague Med Rep, V116, P290, DOI 10.14712/23362936.2015.68
   Solorzano CMB, 2010, REPRODUCTION, V140, P399, DOI 10.1530/REP-10-0119
   Tagi VM, 2022, FRONT ENDOCRINOL, V13, DOI 10.3389/fendo.2022.1061524
   Tagi VM, 2020, CURR OPIN PEDIATR, V32, P582, DOI 10.1097/MOP.0000000000000913
   Tagi VM, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00342
   Tore EC, 2023, EUR J NUTR, V62, P891, DOI 10.1007/s00394-022-03041-4
   Wang Q, 2019, BMC MED, V17, DOI 10.1186/s12916-019-1440-4
   Wopereis S, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004525
   Younsi M, 2002, METABOLISM, V51, P1261, DOI 10.1053/meta.2002.35184
   Yu EA, 2021, J NUTR, V151, P3284, DOI 10.1093/jn/nxab263
NR 41
TC 1
Z9 1
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD AUG 27
PY 2024
VL 23
IS 1
AR 315
DI 10.1186/s12933-024-02412-x
PG 9
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA E0K7Q
UT WOS:001299987700002
PM 39192263
OA gold
DA 2025-06-11
ER

PT J
AU Darvishi, M
   Alsaraf, KM
   Toama, MA
   Hadrawi, SK
   Ramadan, MF
   Pirhadi, M
   Adeli, OA
AF Darvishi, Mohammad
   Alsaraf, Khulood Majid
   Toama, Mariam Alaa
   Hadrawi, Salema K.
   Ramadan, Montather F.
   Pirhadi, Mohadeseh
   Adeli, Omid-Ali
TI A Review of the Effects of Omega-3 and Omega-6 on Alcoholic and
   Non-Alcoholic Fatty Liver
SO ADVANCEMENTS IN LIFE SCIENCES
LA English
DT Review
DE Omega-3; Omega-6; NAFLD; EPA; DHA
ID CARDIOVASCULAR-DISEASE; BARIATRIC SURGERY; OMEGA-3-FATTY-ACIDS; ACID;
   STEATOHEPATITIS; SUPPLEMENTATION; INVOLVEMENT; CHILDREN; EXERCISE; CELLS
AB Non-alcoholic fatty liver disease is a type of fatty fat that causes an increase in alcohol consumption. Excessive alcohol consumption causes inflammation, and liver damage. The certain fatty acids (FAs) may be involved in this liver damage. Anti-inflammatory and blood lipid lowering effects are the effects of omega-3 unsaturated fatty acids (n-3 PUFAs). NAFLD is the hepatic manifestation of metabolic syndrome because obesity and insulin resistance are the main pathogenic factors of both diseases. NAFLD is a disease associated with metabolic syndrome. Most patients with NAFLD are obese, although the disease can also affect non-obese people. Metabolic and genetic factors play an important role in the occurrence of this disease. Oxidative stress, lipotoxicity and inflammation play a key role in the development of NAFLD. There is a lot of evidence for the therapeutic potential of omega-3 PUFAs fatty acids (n-3 PUFA), mainly docosahexaenoic acid and eicosatetraenoic acid in the treatment of metabolic diseases due to their antioxidant and anti-inflammatory properties. Therefore, in this review article, we examined the effects of omega-3 and omega-6 on alcoholic and non-alcoholic fatty liver disease.
C1 [Darvishi, Mohammad] AJA Univ Med Sci, Infect Dis & Trop Med Res Ctr IDTMRC, Dept Aerosp & Subaquat Med, Tehran, Iran.
   [Toama, Mariam Alaa] Natl Univ Sci & Technol, Coll Pharm, Dhi Qar, Iraq.
   [Hadrawi, Salema K.] Islamic Univ, Coll Tech Engn, Refrigerat & Air Conditioning Tech Engn Dept, Najaf, Iraq.
   [Ramadan, Montather F.] Al Ayen Univ, Coll Dent, Thi Qar, Iraq.
   [Pirhadi, Mohadeseh] Univ Tehran Med Sci, Sch Publ Hlth, Dept Environm Hlth, Food Safety Div, Tehran, Iran.
   [Adeli, Omid-Ali] Lorestan Univ Med Sci, Sch Med, Dept Pathol, Khorramabad, Iran.
   [Adeli, Omid-Ali] Lorestan Univ Med Sci, Razi Herbal Med Res Ctr, Khorramabad, Iran.
C3 National University of Science & Technology - Iraq; Islamic University
   College; Al-Ayen University; Tehran University of Medical Sciences;
   Lorestan University of Medical Sciences; Lorestan University of Medical
   Sciences
RP Adeli, OA (corresponding author), Lorestan Univ Med Sci, Sch Med, Dept Pathol, Khorramabad, Iran.; Adeli, OA (corresponding author), Lorestan Univ Med Sci, Razi Herbal Med Res Ctr, Khorramabad, Iran.
EM omidalieadeli@yahoo.com
FU Shahid Beheshti University of Medical Sciences, Tehran, Iran
FX The authors thankful from Shahid Beheshti University of Medical
   Sciences, Tehran, Iran for the support. The co-corresponding author of
   the article is Dr. Nasrullah Naghdi.
CR Abbasi N, 2014, PHYTOTHER RES, V28, P1301, DOI 10.1002/ptr.5128
   Alwayn IPJ, 2005, TRANSPLANTATION, V79, P606, DOI 10.1097/01.TP.0000150023.86487.44
   Bahmani M., 2015, Journal of Chemical and Pharmaceutical Research, V7, P646
   Bonsembiante L, 2022, EUR J CLIN NUTR, V76, P28, DOI 10.1038/s41430-021-00928-z
   Bower G, 2015, OBES SURG, V25, P2280, DOI 10.1007/s11695-015-1691-x
   Calder PC, 2010, CELL MOL BIOL, V56, P28, DOI 10.1170/T876
   Calder PC, 2015, BBA-MOL CELL BIOL L, V1851, P469, DOI 10.1016/j.bbalip.2014.08.010
   Calder PC, 2011, EUR J PHARMACOL, V668, pS50, DOI 10.1016/j.ejphar.2011.05.085
   Cansancao K, 2020, Nutriton, V12, P3
   Chalasani N, 2015, Springer, V23, P5
   Chen LH, 2018, CLIN NUTR, V37, P516, DOI 10.1016/j.clnu.2016.12.009
   Cussons AJ, 2009, J CLIN ENDOCR METAB, V94, P3842, DOI 10.1210/jc.2009-0870
   Darvishi M., 2020, Iran J. Med. Microbiol., V14, P162, DOI [10.30699/ijmm.14.2.162, DOI 10.30699/IJMM.14.2.162]
   Darvishi M, 2017, BIOMED RES-INDIA, V28, P4630
   Darvishi M, 2016, J PURE APPL MICROBIO, V10, P2663, DOI 10.22207/JPAM.10.4.24
   Darvishi Mohammad, 2015, Acta Med Iran, V53, P220
   Dasarathy S, 2015, J CLIN GASTROENTEROL, V49, P137, DOI 10.1097/MCG.0000000000000099
   de Castro GS, 2018, CLIN NUTR, V37, P37, DOI 10.1016/j.clnu.2017.01.006
   Della Corte C, 2018, Advances in Food and Nutrition Research, P59
   Dionysopoulos G, 2021, Clinical Nutrition Espain, V46, P54
   El-Badry AM, 2007, J HEPATOL, V47, P718, DOI 10.1016/j.jhep.2007.08.005
   Falih Baraa T., 2022, Caspian Journal of Environmental Sciences, V20, P785, DOI 10.22124/CJES.2022.5765
   Forootan M, 2018, J CANCER, V9, P213, DOI 10.7150/jca.21854
   Geramizadeh Bita, 2010, J Gastrointest Cancer, V41, P193
   Ghiasi S, 2021, Aquatic Animals Nutrition, V7, P69
   He XX, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0162368
   Hodson L, 2020, P NUTR SOC, V79, P30, DOI 10.1017/S0029665119000569
   Hosseinnia E, 2020, Aquatic Animals Nutrition, V6, P27
   Jalalmanesh S, 2017, Shiraz E-Medical Journal, V30, P18
   Jiang H, 2022, CLIN NUTR, V41, P1798, DOI 10.1016/j.clnu.2022.06.034
   Jump DB, 2018, PHARMACOL THERAPEUT, V181, P108, DOI 10.1016/j.pharmthera.2017.07.007
   Jump DB, 2015, ADV NUTR, V6, P694, DOI 10.3945/an.115.009423
   Jump DB, 2013, ANNU REV NUTR, V33, P249, DOI 10.1146/annurev-nutr-071812-161139
   Karimi E, 2019, DRUG DES DEV THER, V13, P2513, DOI 10.2147/DDDT.S214454
   Keating SE, 2015, J HEPATOL, V63, P174, DOI 10.1016/j.jhep.2015.02.022
   Kotronen A, 2008, ARTERIOSCL THROM VAS, V28, P27, DOI 10.1161/ATVBAHA.107.147538
   Lassailly G, 2015, GASTROENTEROLOGY, V149, P379, DOI 10.1053/j.gastro.2015.04.014
   Lazo M, 2008, SEMIN LIVER DIS, V28, P339, DOI 10.1055/s-0028-1091978
   Lee CH, 2020, NUTRIENTS, V12, DOI 10.3390/nu12092769
   Lee S, 2007, HEPATOLOGY, V45, P841, DOI 10.1002/hep.21645
   Liu CH, 2022, PloS one, V17
   Lytle KA, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0173376
   Mandil O, 2023, CLIN EXP DENT RES, V9, P568, DOI 10.1002/cre2.751
   Manouchehri N, 2022, J Biochem Phytomed, V1, P3, DOI [10.34172/jbp.2022.2, DOI 10.34172/JBP.2022.2]
   Manouchehri N, 2023, Journal of Biochemical Phytomedicine, P1
   Manouchehri N, 2023, CLIN EXP DENT RES, V9, P653, DOI 10.1002/cre2.744
   Masterton GS, 2010, ALIMENT PHARM THER, V31, P679, DOI 10.1111/j.1365-2036.2010.04230.x
   Miri M., 2017, Aquatic Animals Nutrition, V3, P1
   Miura K, 2016, NUTR RES, V36, P1202, DOI 10.1016/j.nutres.2016.09.006
   Musa-Veloso K, 2018, NUTR REV, V76, P581, DOI 10.1093/nutrit/nuy022
   Mussavi M, 2014, IRAN J PEDIATR, V24, P697
   Nobili V, 2015, J PEDIATR GASTR NUTR, V60, P550, DOI 10.1097/MPG.0000000000000715
   Oboodiat M, 2021, Indian J Forensic Med Toxicol, V15, P3421, DOI [10.37506/ijfmt.v15i3.15830, DOI 10.37506/IJFMT.V15I3.15830]
   Oscarsson J, 2018, J CLIN LIPIDOL, V12, P1390, DOI 10.1016/j.jacl.2018.08.003
   Oseini AM, 2017, LIVER INT, V37, P97, DOI 10.1111/liv.13302
   Parker HM, 2012, J HEPATOL, V56, P944, DOI 10.1016/j.jhep.2011.08.018
   Rehm J, 2013, J HEPATOL, V59, P160, DOI 10.1016/j.jhep.2013.03.007
   Sangouni AA, 2021, CLIN NUTR ESPEN, V44, P130, DOI 10.1016/j.clnesp.2021.06.015
   Sedighi M, 2017, J RES MED SCI, V22, DOI 10.4103/1735-1995.202151
   Seyed-alagheband SA, 2021, CASE REP ONCOL, V14, P1698, DOI 10.1159/000520485
   Seyed-alagheband SA, 2021, INT J SURG CASE REP, V85, DOI 10.1016/j.ijscr.2021.106245
   Shapiro H, 2011, CLIN NUTR, V30, P6, DOI 10.1016/j.clnu.2010.06.001
   Simopoulos AP, 2008, EXP BIOL MED, V233, P674, DOI 10.3181/0711-MR-311
   Smíd V, 2022, HEPATOL COMMUN, V6, P1336, DOI 10.1002/hep4.1906
   Song Q, 2019, Scientific Reports, V9, P1
   Sung KC, 2016, J HEPATOL, V65, P791, DOI 10.1016/j.jhep.2016.05.026
   Szostak A, 2016, GENES NUTR, V11, DOI 10.1186/s12263-016-0517-4
   Tobin D, 2018, NUTRIENTS, V10, DOI 10.3390/nu10081126
   Valantinas J, 2012, MED SCI MONITOR, V18, pPH57, DOI 10.12659/MSM.882722
   Yan JH, 2018, MEDICINE, V97, DOI [10.1097/md.0000000000012271, 10.1097/MD.0000000000012271]
   Younossi ZM, 2012, MEDICINE, V91, P319, DOI 10.1097/MD.0b013e3182779d49
   Yu L, 2017, PAK J MED SCI, V33, P1022, DOI 10.12669/pjms.334.12315
   Zhuang P, 2019, CLIN NUTR, V38, P848, DOI 10.1016/j.clnu.2018.02.019
NR 73
TC 1
Z9 1
U1 2
U2 3
PU The Running Line
PI Lahore
PA 79-A Block, Punjab University Town 1, Abdul Sattar Edhi road, Niaz Baig,
   Lahore, PAKISTAN
SN 2310-5380
J9 ADV LIFE SCI-PAK
JI Advan. Life Sci.
PD DEC
PY 2023
VL 10
IS 4
BP 530
EP 536
PG 7
WC Biology
WE Emerging Sources Citation Index (ESCI)
SC Life Sciences & Biomedicine - Other Topics
GA FI9I3
UT WOS:001145245500017
DA 2025-06-11
ER

PT J
AU Benotti, P
   Wood, GC
   Argyropoulos, G
   Pack, A
   Keenan, BT
   Gao, X
   Gerhard, G
   Still, C
AF Benotti, Peter
   Wood, G. Craig
   Argyropoulos, George
   Pack, Allan
   Keenan, Brendan T.
   Gao, Xiang
   Gerhard, Glenn
   Still, Christopher
TI The impact of obstructive sleep apnea on nonalcoholic fatty liver
   disease in patients with severe obesity
SO OBESITY
LA English
DT Article
ID CHRONIC INTERMITTENT HYPOXIA; INSULIN-RESISTANCE; SURGICAL-PATIENTS;
   STEATOHEPATITIS; OXYGEN; PREVALENCE; DIAGNOSIS; HISTOLOGY; STRESS;
   ADULTS
AB ObjectiveObstructive sleep apnea (OSA) is common among candidates for bariatric surgery. OSA and its associated intermittent hypoxia have been implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis. A large cohort of bariatric surgery patients was studied in an effort to explore the relationship between OSA severity, hypoxia, metabolic syndrome, and the severity of NAFLD.
   MethodsBariatric surgery candidates who underwent both polysomnography and liver biopsy were studied. The severity of OSA as determined by the apnea-hypopnea index (AHI) and parameters of hypoxia was studied in relation to extent of abnormalities of liver histology as measured by the presence of hepatic steatosis, inflammation, and fibrosis.
   ResultsThe study cohort included 362 patients with a mean age of 46.2 years and BMI of 49.9 kg/m(2). On the basis of AHI, 26% of the cohort had no OSA, 32% mild OSA, 22% moderate OSA, and 20% severe OSA. For the study subjects without metabolic syndrome, positive correlations were found between OSA severity, as measured by AHI, and parameters of hypoxia, with the severity of NAFLD.
   ConclusionsOSA severity and its accompanying hypoxia are associated with the severity of NAFLD.
C1 [Benotti, Peter; Wood, G. Craig; Argyropoulos, George; Still, Christopher] Geisinger Obes Inst, Danville, PA USA.
   [Pack, Allan; Keenan, Brendan T.] Univ Penn, Philadelphia, PA 19104 USA.
   [Gao, Xiang] Penn State Univ, University Pk, PA 16802 USA.
   [Gerhard, Glenn] Temple Univ, Philadelphia, PA 19122 USA.
C3 University of Pennsylvania; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); Pennsylvania State University; Pennsylvania State
   University - University Park; Penn State Behrend; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Temple University
RP Benotti, P (corresponding author), Geisinger Obes Inst, Danville, PA USA.
EM pbenotti64@gmail.com
RI Keenan, Brendan/HPH-2801-2023; Gao, Xiang/KFQ-2812-2024
OI Gao, Xiang/0000-0003-2617-6509; Keenan, Brendan/0000-0002-9070-847X;
   Pack, Allan/0000-0002-2879-0484
FU Mid-Atlantic Nutrition Obesity Research Center [DK072488]
FX This research was supported by grant DK072488 from the Mid-Atlantic
   Nutrition Obesity Research Center.
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Aron-Wisnewsky J, 2012, J HEPATOL, V56, P225, DOI 10.1016/j.jhep.2011.04.022
   Broughan TA, 2008, J SURG RES, V145, P150, DOI 10.1016/j.jss.2007.04.014
   Chalasani N, 2012, GASTROENTEROLOGY, V142, P1592, DOI 10.1053/j.gastro.2012.04.001
   Chung F, 2012, ANESTH ANALG, V114, P993, DOI 10.1213/ANE.0b013e318248f4f5
   Corey KE, 2015, DIGEST DIS SCI, V60, P2523, DOI 10.1007/s10620-015-3650-8
   Gerhard GS, 2014, J OBES, V2014, DOI 10.1155/2014/368210
   Ip MSM, 2002, AM J RESP CRIT CARE, V165, P670, DOI 10.1164/ajrccm.165.5.2103001
   Jungermann K, 2000, HEPATOLOGY, V31, P255, DOI 10.1002/hep.510310201
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Knutson KL, 2007, SLEEP MED REV, V11, P163, DOI 10.1016/j.smrv.2007.01.002
   Madan K, 2006, J CLIN GASTROENTEROL, V40, P930, DOI 10.1097/01.mcg.0000212608.59090.08
   Mishra P, 2008, LIVER INT, V28, P1080, DOI 10.1111/j.1478-3231.2008.01822.x
   Musso G, 2012, SEMIN LIVER DIS, V32, P49, DOI 10.1055/s-0032-1306426
   Musso G, 2011, ANN MED, V43, P617, DOI 10.3109/07853890.2010.518623
   Peppard PE, 2013, AM J EPIDEMIOL, V177, P1006, DOI 10.1093/aje/kws342
   Piguet AC, 2010, CLIN SCI, V118, P401, DOI 10.1042/CS20090313
   Polotsky VY, 2009, AM J RESP CRIT CARE, V179, P228, DOI 10.1164/rccm.200804-608OC
   Rasmussen JJ, 2012, SURG OBES RELAT DIS, V8, P569, DOI 10.1016/j.soard.2011.06.021
   Reinke C, 2011, J APPL PHYSIOL, V111, P881, DOI 10.1152/japplphysiol.00492.2011
   Rinella ME, 2015, JAMA-J AM MED ASSOC, V313, P2263, DOI 10.1001/jama.2015.5370
   Sareli AE, 2011, OBES SURG, V21, P316, DOI 10.1007/s11695-009-9928-1
   Shah N, 2009, CLIN CHEST MED, V30, P455, DOI 10.1016/j.ccm.2009.05.012
   Steiropoulos P, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/675320
   Sundaram SS, 2014, J PEDIATR-US, V164, P699, DOI 10.1016/j.jpeds.2013.10.072
   Tanné F, 2005, HEPATOLOGY, V41, P1290, DOI 10.1002/hep.20725
   Tatsumi K, 2005, HEPATOL RES, V33, P100, DOI 10.1016/j.hepres.2005.09.014
   Türkay C, 2012, RESP CARE, V57, P244, DOI 10.4187/respcare.01184
   Weingarten TN, 2012, OBESITY FACTS, V5, P587, DOI 10.1159/000342677
   Wood GC, 2012, BMC MED INFORM DECIS, V12, DOI 10.1186/1472-6947-12-45
   YOUNG T, 1993, NEW ENGL J MED, V328, P1230, DOI 10.1056/NEJM199304293281704
   Younossi ZM, 2011, CLIN GASTROENTEROL H, V9, P524, DOI 10.1016/j.cgh.2011.03.020
NR 32
TC 33
Z9 34
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD APR
PY 2016
VL 24
IS 4
BP 871
EP 877
DI 10.1002/oby.21409
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA DI6MM
UT WOS:000373613200018
PM 26880657
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Tsuneyama, K
   Baba, H
   Kikuchi, K
   Nishida, T
   Nomoto, K
   Hayashi, S
   Miwa, S
   Nakajima, T
   Nakanishi, Y
   Masuda, S
   Terada, M
   Imura, J
   Selmi, C
AF Tsuneyama, Koichi
   Baba, Hayato
   Kikuchi, Kentaro
   Nishida, Takeshi
   Nomoto, Kazuhiro
   Hayashi, Shinichi
   Miwa, Shigeharu
   Nakajima, Takahiko
   Nakanishi, Yuko
   Masuda, Shinji
   Terada, Mitsuhiro
   Imura, Johji
   Selmi, Carlo
TI Autoimmune Features in Metabolic Liver Disease: A Single-Center
   Experience and Review of the Literature
SO CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
LA English
DT Review
DE Metabolic syndrome; Female sex; Non-alcoholic fatty liver disease
ID PRIMARY BILIARY-CIRRHOSIS; NONALCOHOLIC STEATOHEPATITIS;
   SEX-DIFFERENCES; OXIDATIVE STRESS; T-CELLS; MICE; GENDER; CHOLANGITIS;
   ANTIBODIES; MODEL
AB Non-alcoholic steatohepatitis (NASH) is the progressive phenotype of non-alcoholic fatty liver disease associated with the metabolic syndrome. The existence of autoimmune features in NASH has been reported, but its significance remains unclear. We herein report the autoantibody profile of 54 patients with histologically proven NASH and further determined the development of autoimmunity in three different murine NASH models (monosodium glutamate, CDAA (choline-deficient l-amino acid-defined), and TSOD (Tsumura Suzuki, Obese Diabetes)) at 48 weeks of age. Forty-eight percent (26/54) of NASH cases were positive for antinuclear (ANA) or antimitochondrial antibody and manifested histological signs of overlap with autoimmune hepatitis and primary biliary cirrhosis, respectively. These patients were significantly older (60 +/- 10 versus 50 +/- 16 years), more frequently women (81 % versus 43 %), and with more severe portal inflammatory infiltrate compared with patients without autoimmunity. In one third of mice, regardless of the model, we observed a marked lymphoid infiltrate with non-suppurative cholangitis, and several cases were ANA-positive, but none AMA-positive. Our data suggest that autoimmunity may share some pathogenetic traits with the chronic inflammation of NASH, possibly related to advanced age.
C1 [Tsuneyama, Koichi; Baba, Hayato; Nishida, Takeshi; Nomoto, Kazuhiro; Hayashi, Shinichi; Miwa, Shigeharu; Nakajima, Takahiko; Nakanishi, Yuko; Imura, Johji] Toyama Univ, Dept Diagnost Pathol, Grad Sch Med & Pharmaceut Sci, Toyama 9300194, Japan.
   [Kikuchi, Kentaro] Teikyo Univ, Mizonokuchi Hosp, Dept Internal Med 4, Kanagawa, Japan.
   [Masuda, Shinji] Kouseiren Takaoka Hosp, Dept Pathol, Takaoka, Toyama, Japan.
   [Terada, Mitsuhiro] Kouseiren Takaoka Hosp, Dept Internal Med, Takaoka, Toyama, Japan.
   [Selmi, Carlo] Humanitas Clin & Res Ctr, Div Rheumatol & Clin Immunol, Milan, Italy.
   [Selmi, Carlo] Univ Calif Davis, Div Rheumatol Allergy & Clin Immunol, Davis, CA 95616 USA.
C3 University of Toyama; Teikyo University; University of California
   System; University of California Davis
RP Tsuneyama, K (corresponding author), Toyama Univ, Dept Diagnost Pathol, Grad Sch Med & Pharmaceut Sci, Toyama 9300194, Japan.
EM ktsune@med.u-toyama.ac.jp
RI Selmi, Carlo/ABG-4899-2021
OI Tsuneyama, Koichi/0000-0002-0670-9868; Selmi, Carlo/0000-0002-0323-0376
FU JSPS KAKENHI [0293341, 10293341]; Takeda Science Foundation;
   Grants-in-Aid for Scientific Research [24390181] Funding Source: KAKEN
FX The authors are thankful to Mr. Tokimasa Kumada and Mr. Hideki Hatta for
   their help and technical assistance with experiments and to Ms. Yukari
   Inoue for the excellent support in the manuscript preparation. This work
   was supported by JSPS KAKENHI Grant Numbers 0293341 and 10293341 and a
   Research grant of 2010 Takeda Science Foundation.
CR Agmon-Levin N, 2009, J AUTOIMMUN, V32, P261, DOI 10.1016/j.jaut.2009.02.017
   Albano E, 2012, J HEPATOL, V2012
   Amur S, 2012, J AUTOIMMUN, V38, pJ254, DOI 10.1016/j.jaut.2011.12.001
   Atarashi K, 2011, CURR OPIN IMMUNOL, V23, P761, DOI 10.1016/j.coi.2011.11.002
   Boberg KM, 2011, J HEPATOL, V54, P374, DOI 10.1016/j.jhep.2010.09.002
   Bogdanos DP, 2012, J AUTOIMMUN, V38, pJ156, DOI 10.1016/j.jaut.2011.11.003
   Carp HJA, 2012, J AUTOIMMUN, V38, pJ266, DOI 10.1016/j.jaut.2011.11.016
   De Santis M, 2012, CLIN REV ALLERG IMMU, V42, P92, DOI 10.1007/s12016-011-8293-8
   Fasano A, 2012, CLIN REV ALLERG IMMU, V42, P71, DOI 10.1007/s12016-011-8291-x
   Fischer S, 2013, IMMUNOL RES, V56, P287, DOI 10.1007/s12026-013-8402-2
   Folci M, 2012, CLIN REV ALLERG IMMU, V42, P342, DOI 10.1007/s12016-011-8253-3
   Fujii H, 2009, J ATHEROSCLER THROMB, V16, P893
   Fujisaka S, 2013, DIABETOLOGIA, V56, P1403, DOI 10.1007/s00125-013-2885-1
   Henao-Mejia J, 2013, ADV IMMUNOL, V117, P73, DOI 10.1016/B978-0-12-410524-9.00003-7
   Invernizzi P, 2005, SEMIN LIVER DIS, V25, P298, DOI 10.1055/s-2005-916321
   Kawaratani H, 2008, WORLD J GASTROENTERO, V14, P6655, DOI 10.3748/wjg.14.6655
   Keppeke GD, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0045392
   Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
   Lathrop SK, 2011, NATURE, V478, P250, DOI 10.1038/nature10434
   Lee TP, 2012, AUTOIMMUN REV, V11, pA422, DOI 10.1016/j.autrev.2011.11.020
   Liberal R, 2013, J AUTOIMMUN, V41, P126, DOI 10.1016/j.jaut.2012.11.002
   Lidar M, 2012, CLIN REV ALLERG IMMU, V42, P238, DOI 10.1007/s12016-011-8275-x
   Mahady SE, 2012, CLIN LIVER DIS, V16, P631, DOI 10.1016/j.cld.2012.05.003
   Markle JGM, 2013, SCIENCE, V339, P1084, DOI 10.1126/science.1233521
   Menon R, 2012, J AUTOIMMUN, V38, pJ144, DOI 10.1016/j.jaut.2011.11.004
   Miller FW, 2012, J AUTOIMMUN, V39, P253, DOI 10.1016/j.jaut.2012.05.001
   Miller FW, 2012, J AUTOIMMUN, V39, P259, DOI 10.1016/j.jaut.2012.05.002
   Mitsuyoshi H, 2009, HEPATOL RES, V39, P366, DOI 10.1111/j.1872-034X.2008.00464.x
   Miyakawa H, 2001, J GASTROENTEROL, V36, P33, DOI 10.1007/s005350170151
   Miyakawa H, 2000, HEPATOL RES, V18, P1, DOI 10.1016/S1386-6346(99)00079-0
   Miyashita T, 2012, J TOXICOL SCI, V37, P931, DOI 10.2131/jts.37.931
   Nakanishi Y, 2008, J AUTOIMMUN, V30, P42, DOI 10.1016/j.jaut.2007.11.016
   Nishida T, 2013, LAB INVEST, V93, P230, DOI 10.1038/labinvest.2012.155
   Pennell LM, 2012, J AUTOIMMUN, V38, pJ282, DOI 10.1016/j.jaut.2011.11.013
   Pollard KM, 2012, J AUTOIMMUN, V38, pJ177, DOI 10.1016/j.jaut.2011.11.007
   Potenza MV, 2009, NUTR CLIN PRACT, V24, P560, DOI 10.1177/0884533609342436
   Quintero OL, 2012, J AUTOIMMUN, V38, pJ109, DOI 10.1016/j.jaut.2011.10.003
   Sakaida I, 2005, HEPATOL RES, V33, P128, DOI 10.1016/j.hepres.2005.09.019
   Salunga TL, 2007, J AUTOIMMUN, V29, P78, DOI 10.1016/j.jaut.2007.04.002
   Sasaki Y, 2011, EUR J PHARMACOL, V662, P1, DOI 10.1016/j.ejphar.2011.04.051
   Sasaki Y, 2009, LIFE SCI, V85, P490, DOI 10.1016/j.lfs.2009.07.017
   Sawalha AH, 2012, J AUTOIMMUN, V38, pJ216, DOI 10.1016/j.jaut.2011.11.008
   Selmi C, 2004, J CLIN GASTROENTEROL, V38, P264, DOI 10.1097/00004836-200403000-00013
   Selmi C, 2007, SEMIN LIVER DIS, V27, P129, DOI 10.1055/s-2007-979466
   Selmi C, 2012, J AUTOIMMUN, V39, P249, DOI 10.1016/j.jaut.2012.07.011
   Selmi C, 2012, AUTOIMMUN REV, V11, pA531, DOI 10.1016/j.autrev.2011.11.024
   Selmi C, 2011, LANCET, V377, P1600, DOI 10.1016/S0140-6736(10)61965-4
   Selmi C, 2010, AUTOIMMUN REV, V9, pA267, DOI 10.1016/j.autrev.2009.12.001
   Selmi C, 2009, TRENDS IMMUNOL, V30, P415, DOI 10.1016/j.it.2009.05.006
   Shapira Y, 2012, CLIN REV ALLERG IMMU, V42, P154, DOI 10.1007/s12016-010-8241-z
   Shoenfeld Y, 2012, J AUTOIMMUN, V38, pJ71, DOI 10.1016/j.jaut.2011.12.007
   Smorlesi A, 2012, OBES REV, V13, P83, DOI 10.1111/j.1467-789X.2012.01039.x
   Tian L, 2012, J AUTOIMMUN, V38, P39, DOI 10.1016/j.jaut.2011.12.004
   Toyoda Y, 2011, TOXICOL LETT, V204, P17, DOI 10.1016/j.toxlet.2011.03.031
   Tsuneyama K, 2002, J HEPATOL, V37, P176, DOI 10.1016/S0168-8278(02)00105-8
   Tsuneyama K, 2012, J HEPATOL, V2012
   Wakabayashi K, 2009, CLIN EXP IMMUNOL, V155, P577, DOI 10.1111/j.1365-2249.2008.03837.x
   Wakabayashi K, 2008, HEPATOLOGY, V48, P531, DOI 10.1002/hep.22390
   Wakabayashi K, 2006, HEPATOLOGY, V44, P1240, DOI 10.1002/hep.21385
   Williams CD, 2011, GASTROENTEROLOGY, V140, P124, DOI 10.1053/j.gastro.2010.09.038
   Yang GX, 2008, HEPATOLOGY, V47, P1974, DOI 10.1002/hep.22226
   Yoshikawa Y, 2012, TOXICOL APPL PHARM, V264, P42, DOI 10.1016/j.taap.2012.06.023
   Zhang WC, 2009, HEPATOLOGY, V49, P545, DOI 10.1002/hep.22651
NR 63
TC 36
Z9 38
U1 0
U2 9
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1080-0549
EI 1559-0267
J9 CLIN REV ALLERG IMMU
JI Clin. Rev. Allergy Immunol.
PD AUG
PY 2013
VL 45
IS 1
BP 143
EP 148
DI 10.1007/s12016-013-8383-x
PG 6
WC Allergy; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Allergy; Immunology
GA 185GR
UT WOS:000321955700012
PM 23842720
DA 2025-06-11
ER

PT J
AU Duclos, M
   Pereira, PM
   Barat, P
   Gatta, B
   Roger, P
AF Duclos, M
   Pereira, PM
   Barat, P
   Gatta, B
   Roger, P
TI Increased cortisol bioavailability, abdominal obesity, and the metabolic
   syndrome in obese women
SO OBESITY RESEARCH
LA English
DT Article
DE 11 beta HSD; corticosteroid binding protein; metabolic syndrome;
   glucocorticoid sensitivity
ID PITUITARY-ADRENAL AXIS; BODY-FAT DISTRIBUTION; PERFORMANCE
   LIQUID-CHROMATOGRAPHY; CORTICOSTEROID-BINDING GLOBULIN; CENTRAL
   ADIPOSITY; SENSITIVITY; STRESS; MEN; GLUCOCORTICOIDS; DEXAMETHASONE
AB Objective: This study was conducted to obtain a detailed profile of hypothalamo-pituitary-adrenal (HPA) axis activity and reactivity and its differential relationships with body fat distribution and total fat mass in premenopausal obese women.
   Research Methods and Procedures: Cortisol responses to stimulation (awakening, food intake, exercise) and suppression (0.25 mg dexamethasone), cortisol metabolism, and tissue sensitivity to glucocorticoids were studied in 53 premenopausal obese women grouped according to their waist-to hip ratio: women with abdominal body fat distribution (A-BFD; n = 31) and women with peripheral fat distribution (P-BFD; n = 22).
   Results: Comparatively, A-BFD) women had 1) lower awakening salivary cortisol levels; 2) increased salivary responsiveness to a standardized lunch; 3) similar pituitary sensitivity to dexamethasone but decreased sensitivity of monocytes to dexamethasone; 4) similar 24-hour urinary free cortisol but increased 24-hour urinary ratio of cortisone-to-cortisol; and 5) no difference in corticosteroid binding protein parameters.
   Discussion: Although abdominal obesity is not very different from generalized obesity in terms of HPA function, subtle variations in HPA axis activity and reactivity are evidenced in A-BFD premenopausal obese women.
C1 Univ Bordeaux 2, Inst Francois Magendie, INSERM, U471,Lab Neurogenet & Stress, F-33077 Bordeaux, France.
   CHU Bordeaux, Serv Endocrinol Pediat, Hop Enfants, Bordeaux, France.
   CHU Bordeaux, Hop Haut Leveque, Serv Endocrinol, Pessac, France.
C3 Universite de Bordeaux; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite de Bordeaux; CHU Bordeaux; CHU Bordeaux;
   Universite de Bordeaux
RP Duclos, M (corresponding author), Univ Bordeaux 2, Inst Francois Magendie, INSERM, U471,Lab Neurogenet & Stress, Rue C Saint Saens, F-33077 Bordeaux, France.
EM duclos@pop.bordeaux.inserm.fr
RI Barat, Pascal/E-4013-2017; Duclos, Martine/AAI-5684-2020
OI Cherifi, Blandine/0000-0002-7399-1330; BARAT, Pascal/0000-0001-5029-0200
CR ALVINERIE M, 1982, J PHARM SCI-US, V71, P816, DOI 10.1002/jps.2600710724
   Andrew R, 1998, J CLIN ENDOCR METAB, V83, P1806, DOI 10.1210/jc.83.5.1806
   [Anonymous], On the professional class of merchants and notaries who copied, preserved
   Björntorp P, 2000, NUTRITION, V16, P924, DOI 10.1016/S0899-9007(00)00422-6
   Boullu-Ciocca S, 2003, OBES RES, V11, P925, DOI 10.1038/oby.2003.127
   BRANDENBERGER G, 1982, J CLIN ENDOCR METAB, V54, P592, DOI 10.1210/jcem-54-3-592
   COSTE J, 1994, BRIT J CLIN PHARMACO, V38, P474, DOI 10.1111/j.1365-2125.1994.tb04386.x
   DONAHUE RP, 1987, LANCET, V1, P821
   Duclos M, 1999, J ENDOCRINOL INVEST, V22, P465, DOI 10.1007/BF03343591
   Duclos M, 2003, J APPL PHYSIOL, V94, P869, DOI 10.1152/japplphysiol.00108.2002
   Duclos M, 2001, CLIN ENDOCRINOL, V55, P447, DOI 10.1046/j.1365-2265.2001.01384.x
   Ebrecht M, 2000, J CLIN ENDOCR METAB, V85, P3733, DOI 10.1210/jc.85.10.3733
   Fernandez-Real JM, 2002, J CLIN ENDOCR METAB, V87, P4686, DOI 10.1210/jc.2001-011843
   Gardet V, 2001, J HYPERTENS, V19, P1029, DOI 10.1097/00004872-200106000-00006
   HAMMOND GL, 1990, ENDOCR REV, V11, P65, DOI 10.1210/edrv-11-1-65
   HAUNER H, 1987, J CLIN ENDOCR METAB, V64, P832, DOI 10.1210/jcem-64-4-832
   Hay M, 1997, J CHROMATOGR B, V702, P33, DOI 10.1016/S0378-4347(97)00361-7
   Jessop DS, 2001, J CLIN ENDOCR METAB, V86, P4109, DOI 10.1210/jc.86.9.4109
   Kamel EG, 2000, OBES RES, V8, P36, DOI 10.1038/oby.2000.6
   Korbonits M, 1996, CLIN ENDOCRINOL, V45, P699, DOI 10.1046/j.1365-2265.1996.8550865.x
   LAMBILLOTTE C, 1997, J CLIN INVEST, V99, P2094
   LAUDAT MH, 1988, J CLIN ENDOCR METAB, V66, P343, DOI 10.1210/jcem-66-2-343
   Mattson JP, 2000, MED SCI SPORT EXER, V32, P365, DOI 10.1097/00005768-200002000-00016
   Pasquali R, 1996, METABOLISM, V45, P351, DOI 10.1016/S0026-0495(96)90290-5
   Pasquali R, 2002, J CLIN ENDOCR METAB, V87, P166, DOI 10.1210/jc.87.1.166
   Pasquali R, 1998, CLIN ENDOCRINOL, V48, P603, DOI 10.1046/j.1365-2265.1998.00458.x
   Pruessner JC, 1997, LIFE SCI, V61, P2539, DOI 10.1016/S0024-3205(97)01008-4
   PUGEAT MM, 1984, ENDOCRINOLOGY, V115, P1675
   Radloff LS., 1977, APPL PSYCH MEAS, V1, P385, DOI [10.1177/014662167700100306, DOI 10.1177/014662167700100306]
   Rask E, 2002, J CLIN ENDOCR METAB, V87, P3330, DOI 10.1210/jc.87.7.3330
   REBUFFESCRIVE M, 1992, PHYSIOL BEHAV, V52, P583, DOI 10.1016/0031-9384(92)90351-2
   Rosmond R, 1998, J CLIN ENDOCR METAB, V83, P1853, DOI 10.1210/jc.83.6.1853
   Stewart PM, 1999, J CLIN ENDOCR METAB, V84, P1022, DOI 10.1210/jc.84.3.1022
   STRAIN GW, 1982, METABOLISM, V31, P209, DOI 10.1016/0026-0495(82)90054-3
   STRAIN GW, 1980, METABOLISM, V29, P980, DOI 10.1016/0026-0495(80)90043-8
   Tataranni PA, 1997, OBES RES, V5, P341, DOI 10.1002/j.1550-8528.1997.tb00562.x
   Vozarova B, 2002, DIABETES, V51, P455, DOI 10.2337/diabetes.51.2.455
   WEAVER JU, 1993, CLIN ENDOCRINOL, V39, P345, DOI 10.1111/j.1365-2265.1993.tb02375.x
   WEIR JBD, 1990, NUTRITION, V6, P213
   YANOVSKI JA, 1993, JAMA-J AM MED ASSOC, V269, P2232, DOI 10.1001/jama.1993.03500170062035
NR 40
TC 116
Z9 126
U1 0
U2 9
PU NORTH AMER ASSOC STUDY OBESITY
PI SILVER SPRING
PA 8630 FENTON ST, SUITE 918, SILVER SPRING, MD 20910 USA
SN 1071-7323
J9 OBES RES
JI Obes. Res.
PD JUL
PY 2005
VL 13
IS 7
BP 1157
EP 1166
DI 10.1038/oby.2005.137
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 955GE
UT WOS:000231212800006
PM 16076984
OA Bronze
DA 2025-06-11
ER

PT J
AU Shin, SK
   Kwon, EY
AF Shin, Su-Kyung
   Kwon, Eun-Young
TI Kaempferol ameliorates metabolic syndrome by inhibiting inflammation and
   oxidative stress in high-fat diet-induced obese mice
SO NUTRITION RESEARCH AND PRACTICE
LA English
DT Article
DE Obesity; inflammation; oxidative stress; fatty liver; metabolic syndrome
ID INSULIN-RESISTANCE; ADIPOSE-TISSUE; LIVER; DYSFUNCTION; QUERCETIN;
   ASSAY; RISK; ACID
AB BACKGROUND/OBJECTIVES: Kaempferol (Ka) is one of the most widely occurring flavonoids found in large amounts in various plants. Ka has anti-obesity, antioxidant, and antiinflammatory effects. Despite the numerous papers documenting the efficacy of Ka, some controversy remains. Therefore, this study examined the impact of Ka using 3T3 -L1 and highfat diet-induced obese mice. MATERIALS/METHODS: 3T3 -L1 cells were treated with 50 mu M Ka from the initiation of 3T3 -L1 differentiation at D0 until the completion of differentiation on D8. Thirty male mice (C57BL/6J, 4 weeks old) were divided into 3 groups: normal diet (ND), high -fat diet (HFD), and HFD + 0.02% (w/w) Ka (Ka) group. All mice were fed their respective diets ad libitum for 16 weeks. The mice were sacrificed, and the plasma and hepatic lipid levels, white adipose tissue weight, hepatic glucose level, lipid level, and antioxidant enzyme activities were analyzed, and immunohistochemistry staining was performed. RESULTS: Ka suppressed the hypertrophy of 3T3 -L1 cells, and the Ka-supplemented mice showed a significant decrease in perirenal, retroperitoneal, mesenteric, and subcutaneous fat compared to the HFD group. Ka supplementation in high -fat diet-induced obese mice also improved the overall blood lipid concentration (total cholesterol, non-high-density lipoprotein-cholesterol, phospholipids, and apolipoprotein B). Ka supplementation in highfat-induced obesity mice reduced hepatic steatosis and insulin resistance by modulating the hepatic lipid (glucose-6-phosphate dehydrogenase, fatty acid synthase, malic enzyme, phosphatidate phosphohydrolase, and beta -oxidation) activities and glucose (glucokinase, phosphoenolpyruvate carboxykinase, and G6pase)-regulating enzymes. Ka supplementation ameliorated the erythrocyte and hepatic mitochondrial H 2 O 2 and inflammation levels (plasma tumor necrosis factor-alpha, monocyte chemoattractant protein -1, interleukin-6, and interferon -gamma and fibrosis of liver and epididymal fat). CONCLUSION: Ka may be beneficial for preventing diet-induced obesity, inflammation, oxidative stress, and diabetes.
C1 [Shin, Su-Kyung; Kwon, Eun-Young] Kyungpook Natl Univ, Dept Food Sci & Nutr, 80 Daehak Ro, Daegu 41566, South Korea.
   [Shin, Su-Kyung; Kwon, Eun-Young] Kyungpook Natl Univ, Ctr Food & Nutr Genom Res, Daegu 41566, South Korea.
   [Kwon, Eun-Young] Kyungpook Natl Univ, Ctr Beautiful Aging, Daegu 41566, South Korea.
C3 Kyungpook National University (KNU); Kyungpook National University
   (KNU); Kyungpook National University (KNU)
RP Kwon, EY (corresponding author), Kyungpook Natl Univ, Dept Food Sci & Nutr, 80 Daehak Ro, Daegu 41566, South Korea.
EM eykwon@knu.ac.kr
OI Shin, Su-Kyung/0000-0002-8918-3995
FU National Research Foundation of Korea (NRF) - Korea government (MSIT)
   [RS-2023-00237118, 2021R1A2C1011233]
FX Funding This work was supported by the National Research Foundation of
   Korea (NRF) grant funded by the Korea government (MSIT) (No.
   RS-2023-00237118 and No. 2021R1A2C1011233) .
CR AEBI H, 1984, METHOD ENZYMOL, V105, P121
   Aguilera CM, 2008, CLIN SCI, V114, P183, DOI 10.1042/CS20070115
   ALEGRE M, 1988, ANAL BIOCHEM, V173, P185, DOI 10.1016/0003-2697(88)90176-5
   An GH, 2011, DRUG METAB DISPOS, V39, P426, DOI 10.1124/dmd.110.035212
   Arfian Nur, 2019, BMC Proc, V13, P17, DOI 10.1186/s12919-019-0181-x
   Bastard JP, 2002, J CLIN ENDOCR METAB, V87, P2084, DOI 10.1210/jc.87.5.2084
   BENTLE LA, 1976, J BIOL CHEM, V251, P2916
   Bian YF, 2022, J NUTR BIOCHEM, V99, DOI 10.1016/j.jnutbio.2021.108840
   CARROLL NV, 1956, J BIOL CHEM, V220, P583
   Chawla A, 2011, NAT REV IMMUNOL, V11, P738, DOI 10.1038/nri3071
   Christensen KB, 2010, PHYTOTHER RES, V24, pS129, DOI 10.1002/ptr.3005
   Crespo I, 2008, BRIT J NUTR, V100, P968, DOI 10.1017/S0007114508966083
   Da-Silva WS, 2007, DIABETES, V56, P767, DOI 10.2337/db06-1488
   DAVIDSON AL, 1987, ARCH BIOCHEM BIOPHYS, V253, P156, DOI 10.1016/0003-9861(87)90648-5
   Fang Z, 2017, HYPERTENSION, V69, P770, DOI 10.1161/HYPERTENSIONAHA.116.08451
   Fried SK, 1998, J CLIN ENDOCR METAB, V83, P847, DOI 10.1210/jc.83.3.847
   García-Ruiz I, 2006, HEPATOLOGY, V44, P581, DOI 10.1002/hep.21313
   GILLIES PJ, 1986, EXP MOL PATHOL, V44, P329, DOI 10.1016/0014-4800(86)90046-8
   Häkkinen SH, 1999, J AGR FOOD CHEM, V47, P2274, DOI 10.1021/jf9811065
   Hämäläinen M, 2007, MEDIAT INFLAMM, V2007, DOI 10.1155/2007/45673
   Jakubiak GK, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11010079
   Juhan-Vague I, 2003, J THROMB HAEMOST, V1, P1575, DOI 10.1046/j.1538-7836.2003.00279.x
   Kahn BB, 2000, J CLIN INVEST, V106, P473, DOI 10.1172/JCI10842
   Lazarow P B, 1981, Methods Enzymol, V72, P315
   Lee YJ, 2010, PHYTOTHER RES, V24, P419, DOI 10.1002/ptr.2983
   MARKLUND S, 1974, EUR J BIOCHEM, V47, P469
   MARKWELL MA, 1973, J BIOL CHEM, V248, P3426
   Martin S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046242
   McCullough AJ, 2006, J CLIN GASTROENTEROL, V40, pS17
   Nainu F, 2023, HELIYON, V9, DOI 10.1016/j.heliyon.2023.e16919
   Nepokroeff C M, 1975, Methods Enzymol, V35, P37, DOI 10.1016/0076-6879(75)35136-7
   Ng M, 2014, LANCET, V384, P766, DOI 10.1016/S0140-6736(14)60460-8
   Ninomiya K, 2007, BIOORG MED CHEM LETT, V17, P3059, DOI 10.1016/j.bmcl.2007.03.051
   OHKAWA H, 1979, ANAL BIOCHEM, V95, P351, DOI 10.1016/0003-2697(79)90738-3
   PAGLIA DE, 1967, J LAB CLIN MED, V70, P158
   Park K, 2009, DIABETES CARE, V32, P1302, DOI 10.2337/dc09-0259
   Picchi A, 2006, CIRC RES, V99, P69, DOI 10.1161/01.RES.0000229685.37402.80
   Pitkanen E, 1997, EUR J CLIN CHEM CLIN, V35, P761
   Pradhan A, 2007, NUTR REV, V65, pS152, DOI 10.1301/nr.2007.dec.S152-S156
   Reho JJ, 2017, CLIN SCI, V131, P1689, DOI 10.1042/CS20170219
   Saltiel AR, 2017, J CLIN INVEST, V127, P1, DOI [10.1172/JCI92035, 10.1172/jci92035]
   Shah S, 2007, ANTIOXID REDOX SIGN, V9, P911, DOI 10.1089/ars.2007.1629
   SHAPIRO DJ, 1974, BIOCHIM BIOPHYS ACTA, V370, P369, DOI 10.1016/0005-2744(74)90098-9
   Shimomura I, 1996, NAT MED, V2, P800, DOI 10.1038/nm0796-800
   Shoelson SE, 2007, GASTROENTEROLOGY, V132, P2169, DOI 10.1053/j.gastro.2007.03.059
   Spranger J, 2003, DIABETES, V52, P812, DOI 10.2337/diabetes.52.3.812
   Steppan CM, 2001, NATURE, V409, P307, DOI 10.1038/35053000
   Suh KS, 2009, BIOL PHARM BULL, V32, P746, DOI 10.1248/bpb.32.746
   Tarrats N, 2011, HEPATOLOGY, V54, P319, DOI 10.1002/hep.24388
   Torres-Villarreal D, 2019, J PHYSIOL BIOCHEM, V75, P83, DOI 10.1007/s13105-018-0659-4
   Yu SF, 2006, BIOL PHARM BULL, V29, P2510, DOI 10.1248/bpb.29.2510
NR 51
TC 2
Z9 2
U1 3
U2 5
PU KOREAN NUTRITION SOC
PI SEOUL
PA 804 KST CTR, 635-4 YEOGSAM-SONG KANGNAM-KU, SEOUL, 135-703, SOUTH KOREA
SN 1976-1457
EI 2005-6168
J9 NUTR RES PRACT
JI Nutr. Res. Pract.
PD JUN
PY 2024
VL 18
IS 3
BP 325
EP 344
DI 10.4162/nrp.2024.18.3.325
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA TR4J7
UT WOS:001242971000002
PM 38854471
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Solomon, Z
   Levin, Y
   Ben Assayag, E
   Furman, O
   Shenhar-Tsarfaty, S
   Berliner, S
   Ohry, A
AF Solomon, Zahava
   Levin, Yafit
   Ben Assayag, Einor
   Furman, Orit
   Shenhar-Tsarfaty, Shani
   Berliner, Shlomo
   Ohry, Avi
TI The Implication of Combat Stress and PTSD Trajectories in Metabolic
   Syndrome and Elevated C-Reactive Protein Levels: A Longitudinal Study
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID WORLD-WAR-II; CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE;
   PSYCHIATRIC-DISORDERS; INFLAMMATORY MARKERS; INCIDENT CORONARY; FORMER
   PRISONERS; RISK-FACTORS; MORTALITY; VETERANS
AB Objective: This study sheds light on the importance of long-term follow-up of trauma survivors, posttraumatic stress disorder (PTSD) trajectories, and early detection of health risk factors in trauma survivors. The present study prospectively assessed the following over 23 years: (1) the association of psychological and physiologic stress during captivity with elevated C-reactive protein (CRP) levels and metabolic syndrome (MetS), which includes hypertension; elevated levels of insulin, triglycerides, and fasting glucose; decreased levels of high-density lipoprotein cholesterol; and obesity and (2) the implication of PTSD trajectories in elevated CRP levels and MetS.
   Methods: Measurements were taken in 1991, 2003, 2008, and 2015. Participants were 116 Israeli combat veterans of the 1973 Yom Kippur War (of these, 101 were former prisoners of war [ex-POWs] and 15 were comparable controls). The medical assessments relevant for this study were body mass index, fasting blood glucose levels, and diabetes, blood pressure or a diagnosis of hypertension, high-density lipoprotein cholesterol and triglyceride levels, and medication intake. In addition, the PTSD Inventory was used to assess PTSD symptoms and trajectories over time according to DSM-IV-TR PTSD criteria.
   Results: Captivity-in particular, the captivity stressors of weight loss, physical suffering, psychological suffering, and humiliation-was implicated in both elevated CRP levels and MetS, significantly so with elevated CRP levels (P=.01, R-2 = 0.33). Captivity-induced PTSD, in particular chronic and delayed PTSD trajectories, was associated with elevated CRP levels and MetS, significantly so for MetS (P=.05).
   Conclusions: Monitoring inflammation using markers like CRP level in trauma survivors can be beneficial, particularly if PTSD is chronic or delayed. Clinicians treating trauma survivors should raise awareness of the importance of such measures in light of long-term health vulnerabilities. (C) Copyright 2017 Physicians Postgraduate Press, Inc.
C1 [Solomon, Zahava; Levin, Yafit] Tel Aviv Univ, Bob Shapell Sch Social Work, Tel Aviv, Israel.
   [Solomon, Zahava] I Core Res Ctr Mass Trauma, Tel Aviv, Israel.
   [Ben Assayag, Einor; Shenhar-Tsarfaty, Shani; Berliner, Shlomo] Tel Aviv Sourasky Med Ctr, Dept Internal Med, Tel Aviv, Israel.
   [Furman, Orit] Weizmann Inst Sci, Dept Neurobiol, Rehovot, Israel.
   [Furman, Orit] Max Planck Inst Psychiat, Dept Stress Neurobiol & Neurogenet, Munich, Germany.
   [Berliner, Shlomo; Ohry, Avi] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.
C3 Tel Aviv University; Tel Aviv University; Sackler Faculty of Medicine;
   Tel Aviv Sourasky Medical Center; Weizmann Institute of Science; Max
   Planck Society; Tel Aviv University; Sackler Faculty of Medicine
RP Solomon, Z (corresponding author), Tel Aviv Univ, I Core Res Ctr Mass Trauma, Bob Shapell Sch Social Work, POB 39040, IL-69978 Tel Aviv, Israel.
EM solomon@post.tau.ac.il
RI Levin, Yafit/MHR-0455-2025
OI Furman, Orit/0000-0001-6823-9542; Shenhar-Tsarfaty,
   Shani/0000-0002-8268-1799
CR Ahmadi N, 2013, J AM COLL CARDIOL, V61, pE1347, DOI 10.1016/S0735-1097(13)61347-9
   American Psychiatric Association, 2000, DIAGNOSTIC STAT MANU
   Andersen SB, 2014, J CLIN PSYCHIAT, V75, P1001, DOI 10.4088/JCP.13m08914
   [Anonymous], 1977, The SCL-90 manual I: Scoring, administration and procedures for the SCL-90
   [Anonymous], [No title captured], DOI DOI 10.1017/S1092852900007288
   Baumeister D, 2016, MOL PSYCHIATR, V21, P642, DOI 10.1038/mp.2015.67
   Bierhaus A, 2003, P NATL ACAD SCI USA, V100, P1920, DOI 10.1073/pnas.0438019100
   Bonanno GA, 2012, PSYCHOL TRAUMA-US, V4, P74, DOI 10.1037/a0017829
   Boscarino JA, 1999, PSYCHOSOM MED, V61, P378, DOI 10.1097/00006842-199905000-00019
   Boscarino JA, 2006, ANN EPIDEMIOL, V16, P248, DOI 10.1016/j.annepidem.2005.03.009
   Boscarino JA, 2004, ANN NY ACAD SCI, V1032, P141, DOI 10.1196/annals.1314.011
   Boscarino JA, 2008, PSYCHOSOM MED, V70, P668, DOI 10.1097/PSY.0b013e31817bccaf
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Coelho R, 2014, ACTA PSYCHIAT SCAND, V129, P180, DOI 10.1111/acps.12217
   Das SR, 2005, AM J PREV MED, V28, P291, DOI 10.1016/j.amepre.2004.12.007
   Day Caroline, 2007, Diab Vasc Dis Res, V4, P32, DOI 10.3132/dvdr.2007.003
   Dedert EA, 2010, ANN BEHAV MED, V39, P61, DOI 10.1007/s12160-010-9165-9
   Dekel S, 2012, PSYCHOL TRAUMA-US, V4, P94, DOI 10.1037/a0021865
   Dickstein BD, 2010, J TRAUMA STRESS, V23, P331, DOI 10.1002/jts.20523
   EBERLY RE, 1991, HOSP COMMUNITY PSYCH, V42, P807
   Edmondson D, 2013, PROG CARDIOVASC DIS, V55, P548, DOI 10.1016/j.pcad.2013.03.004
   ENGDAHL BE, 1991, J NERV MENT DIS, V179, P181, DOI 10.1097/00005053-199104000-00001
   Eraly SA, 2014, JAMA PSYCHIAT, V71, P423, DOI 10.1001/jamapsychiatry.2013.4374
   Farr OM, 2015, NUTR METAB CARDIOVAS, V25, P479, DOI 10.1016/j.numecd.2015.01.007
   Ford ES, 2005, DIABETES CARE, V28, P1769, DOI 10.2337/diacare.28.7.1769
   Friedman Matthew., 2004, TRAUMA HLTH PHYS HLT, P157, DOI [DOI 10.1037/10723-007, 10.1037/10723-007]
   Friedman MJ, 1995, NEUROBIOLOGICAL CLIN, P507
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032
   Gill JM, 2009, PERSPECT PSYCHIATR C, V45, P262, DOI 10.1111/j.1744-6163.2009.00229.x
   Ginzburg K, 2010, J AFFECT DISORDERS, V123, P249, DOI 10.1016/j.jad.2009.08.006
   Heath NM, 2013, CYTOKINE, V63, P172, DOI 10.1016/j.cyto.2013.04.030
   Heim C, 2009, CNS SPECTRUMS, V14, P13
   Heppner PS, 2012, PSYCHOSOMATICS, V53, P550, DOI 10.1016/j.psym.2012.05.005
   Heppner PS, 2009, BMC MED, V7, DOI 10.1186/1741-7015-7-1
   Hunt SC, 2008, MIL MED, V173, P613, DOI 10.7205/MILMED.173.7.613
   Jordan HT, 2011, PREV MED, V53, P370, DOI 10.1016/j.ypmed.2011.10.014
   Kang HK, 2006, ANN EPIDEMIOL, V16, P381, DOI 10.1016/j.annepidem.2005.03.004
   Karstoft KI, 2013, J CLIN PSYCHIAT, V74, pE1163, DOI [10.4088/JCP.13m08428, 10.4088/JCP.13.m08482]
   Kershaw KN, 2010, HEALTH PSYCHOL, V29, P307, DOI 10.1037/a0019286
   Lagraauw HM, 2015, BRAIN BEHAV IMMUN, V50, P18, DOI 10.1016/j.bbi.2015.08.007
   Levine AB, 2014, CARDIOLOGY, V127, P1, DOI 10.1159/000354910
   Lindqvist D, 2014, BRAIN BEHAV IMMUN, V42, P81, DOI 10.1016/j.bbi.2014.06.003
   McCanlies EC, 2011, CYTOKINE, V55, P74, DOI 10.1016/j.cyto.2011.03.025
   McEwen BS, 1998, ANN NY ACAD SCI, V840, P33, DOI 10.1111/j.1749-6632.1998.tb09546.x
   McFarlane AC, 2010, WORLD PSYCHIATRY, V9, P3
   Michopoulos V, 2015, AM J PSYCHIAT, V172, P353, DOI 10.1176/appi.ajp.2014.14020263
   Miller RJ, 2001, CYTOKINE, V13, P253, DOI 10.1006/cyto.2000.0825
   O'Donnell ML, 2007, BEHAV RES THER, V45, P601, DOI 10.1016/j.brat.2006.03.015
   O'Donovan A, 2015, PSYCHONEUROENDOCRINO, V51, P557, DOI 10.1016/j.psyneuen.2014.11.010
   Orcutt HK, 2004, J TRAUMA STRESS, V17, P195, DOI 10.1023/B:JOTS.0000029262.42865.c2
   Pace TWW, 2011, BRAIN BEHAV IMMUN, V25, P6, DOI 10.1016/j.bbi.2010.10.003
   Pacella ML, 2013, J ANXIETY DISORD, V27, P33, DOI 10.1016/j.janxdis.2012.08.004
   PAGE WF, 1994, J CLIN EPIDEMIOL, V47, P1437, DOI 10.1016/0895-4356(94)90087-6
   Page WF, 2001, MIL MED, V166, P803, DOI 10.1093/milmed/166.9.803
   Pradhan AD, 2002, JAMA-J AM MED ASSOC, V288, P980, DOI 10.1001/jama.288.8.980
   Rasmusson AM, 2010, EXP BIOL MED, V235, P1150, DOI 10.1258/ebm.2010.009334
   Rogowski O, 2005, CLIN CHIM ACTA, V358, P151, DOI 10.1016/j.cccn.2005.02.024
   Rohleder N, 2010, NEUROSCI BIOBEHAV R, V35, P104, DOI 10.1016/j.neubiorev.2009.12.003
   Safran Nadav., 1977, International Security, V2, P133, DOI [10.2307/2538730, DOI 10.2307/2538730]
   SAPOLSKY RM, 1986, ENDOCR REV, V7, P284, DOI 10.1210/edrv-7-3-284
   Sattar N, 2003, CIRCULATION, V108, P414, DOI 10.1161/01.CIR.0000080897.52664.94
   Schnurr P P, 1999, Semin Clin Neuropsychiatry, V4, P295
   SOLOMON Z, 1993, ISRAEL J PSYCHIAT, V30, P110
   Solomon Z., 1989, Journal of Traumatic Stress, V2, P59
   Solomon Z, 2014, J BEHAV MED, V37, P849, DOI 10.1007/s10865-013-9544-3
   Solomon Z, 2012, PSYCHIAT RES, V199, P188, DOI 10.1016/j.psychres.2012.03.035
   Söndergaard HP, 2004, CLIN CHIM ACTA, V342, P93, DOI 10.1016/j.cccn.2003.12.019
   Spitzer C, 2014, NORD J PSYCHIAT, V68, P296, DOI 10.3109/08039488.2013.844271
   Spitzer C, 2010, J PSYCHIATR RES, V44, P15, DOI 10.1016/j.jpsychires.2009.06.002
   Tuomisto K, 2006, THROMB HAEMOSTASIS, V95, P511, DOI 10.1160/TH05-08-0571
   Vaccarino V, 2013, J AM COLL CARDIOL, V62, P970, DOI 10.1016/j.jacc.2013.04.085
   Visser M, 1999, JAMA-J AM MED ASSOC, V282, P2131, DOI 10.1001/jama.282.22.2131
   von Känel R, 2007, J PSYCHIATR RES, V41, P744, DOI 10.1016/j.jpsychires.2006.06.009
   Yehuda R, 2007, NEURON, V56, P19, DOI 10.1016/j.neuron.2007.09.006
   Zoccola PM, 2014, HEALTH PSYCHOL, V33, P1606, DOI 10.1037/hea0000019
NR 76
TC 23
Z9 24
U1 0
U2 12
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD NOV-DEC
PY 2017
VL 78
IS 9
BP E1180
EP E1186
DI 10.4088/JCP.16m11344
PG 7
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA FR0YZ
UT WOS:000418792500004
PM 28994516
DA 2025-06-11
ER

PT J
AU Kagota, S
   Maruyama, K
   Tada, Y
   Fukushima, K
   Umetani, K
   Wakuda, H
   Shinozuka, K
AF Kagota, Satomi
   Maruyama, Kana
   Tada, Yukari
   Fukushima, Kazuhito
   Umetani, Keiji
   Wakuda, Hirokazu
   Shinozuka, Kazumasa
TI Chronic oxidative-nitrosative stress impairs coronary vasodilation in
   metabolic syndrome model rats
SO MICROVASCULAR RESEARCH
LA English
DT Article
ID SOLUBLE GUANYLATE-CYCLASE; NITRIC-OXIDE SYNTHASE; ENDOTHELIAL
   DYSFUNCTION; HYPERTENSIVE-RATS; VASCULAR DYSFUNCTION;
   INSULIN-RESISTANCE; ANGIOTENSIN-II; MIMETIC TEMPOL; ANIMAL-MODEL; HEME
   MOIETY
AB Metabolic syndrome (MetS) is a combination of clinical disorders that together increase the risk for cardiovascular disease and diabetes. SHRSP.Z-Lepr(fa)/IzmDmcr (SHRSP.ZF) rats with MetS show impaired nitric oxide-mediated relaxation in coronary and mesenteric arteries, and angiotensin II receptor type 1 blockers protect against dysfunction and oxidative-nitrosative stress independently of metabolic effects. We hypothesize that superoxide contributes to functional deterioration in SHRSP.ZF rats. To test our hypothesis, we studied effects of treatment with tempol, a membrane-permeable radical scavenger, on impaired vasodilation in SHRSP.ZF rats. Tempol did not alter body weight, high blood pressure, or metabolic abnormalities, but prevented impairment of acetylcholine-induced and nitroprusside-induced vasodilation in the coronary and mesenteric arteries. Furthermore, tempol reduced the levels of serum thiobarbituric acid reactive substance (TEARS) and 3-nitrotyrosine content in mesenteric arteries. Systemic administration of tempol elevated the expression of soluble guanylate cyclase (sGC) above basal levels in mesenteric arteries of SHRSP.ZF rats. However, acute treatment with tempol or ebselen, a peroxynitrite scavenger, did not ameliorate impaired relaxation of isolated mesenteric arteries. No nitration of tyrosine residues in sGC was observed; however, sGC mRNA expression levels in the arteries of SHRSP.ZF rats were lower than those in the arteries of Wistar-Kyoto rats. Levels of Thr(496)- and Ser(1177)-phosphofylated endothelial nitric oxide synthase (eNOS) were lower in arteries of SHRSP.ZF rats, and acetylcholine decreased Thr(496)-phosphorylated eNOS levels. These results indicated that prolonged superoxide production, leading to oxidative-nitrosative stress, was associated with impaired vasodilation in SHRSP.ZF rats with MetS. Down-regulated sGC expression may be linked to dysfunction, while reduced NO bioavailability/eNOS activity and modified sGC activity due to superoxide production were excluded as pivotal mechanisms. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Kagota, Satomi; Maruyama, Kana; Tada, Yukari; Wakuda, Hirokazu; Shinozuka, Kazumasa] Mukogawa Womens Univ, Fac Pharmaceut Sci, Dept Pharmacol, Nishinomiya, Hyogo 663, Japan.
   [Fukushima, Kazuhito] Natl Cerebral & Cardiovasc Ctr, Dept Radiol, Osaka, Japan.
   [Umetani, Keiji] SPring 8, Japan Synchrotron Radiat Res Inst, Sayo, Japan.
C3 Mukogawa Women's University; National Cerebral & Cardiovascular Center -
   Japan; Japan Synchrotron Radiation Research Institute
RP Kagota, S (corresponding author), 11-68 Koshien Kyuban Cho, Nishinomiya, Hyogo 6638179, Japan.
EM skagota@mukogawa-u.ac.jp
RI Wakuda, Hirokazu/KZU-6319-2024
OI Wakuda, Hirokazu/0000-0002-5717-8251
FU Ministry of Education, Sciences, Sports, and Culture of Japan
   [23590315]; Grants-in-Aid for Scientific Research [23590315] Funding
   Source: KAKEN
FX We thank Ms. Yasuko Mino, Ms. Yumie Shinoda and Ms. Naoko Nose for their
   technical assistance. This research was partly supported by a Grant-in
   Aid for Scientific Research from the Ministry of Education, Sciences,
   Sports, and Culture of Japan (23590315). Synchrotron radiation
   experiments were performed at the BL28B2 in SPring-8 (Sayo, Japan) with
   the approval of the Japan Synchrotron Radiation Research Institute
   (2008A1512 and 2008B1050).
CR Beswick RA, 2001, HYPERTENSION, V37, P781, DOI 10.1161/01.HYP.37.2.781
   Ebenezer PJ, 2009, OBESITY, V17, P1994, DOI 10.1038/oby.2009.137
   Erdös B, 2002, AM J PHYSIOL-HEART C, V282, pH2060, DOI 10.1152/ajpheart.01124.2001
   Fleming I, 2003, AM J PHYSIOL-REG I, V284, pR1, DOI 10.1152/ajpregu.00323.2002
   Förstermann U, 2010, PFLUG ARCH EUR J PHY, V459, P923, DOI 10.1007/s00424-010-0808-2
   Fornoni A, 2005, CURR HYPERTENS REP, V7, P88, DOI 10.1007/s11906-005-0080-6
   Hasdan G, 2002, KIDNEY INT, V61, P586, DOI 10.1046/j.1523-1755.2002.00166.x
   Heitzer T, 2001, CIRCULATION, V104, P2673, DOI 10.1161/hc4601.099485
   Hiraoka-Yamamoto J, 2004, CLIN EXP PHARMACOL P, V31, P107, DOI 10.1111/j.1440-1681.2004.04121.x
   Iwasaki H, 2007, ARTERIOSCL THROM VAS, V27, P1326, DOI 10.1161/ATVBAHA.106.137141
   Kagota S, 2011, BRIT J PHARMACOL, V164, P358, DOI 10.1111/j.1476-5381.2011.01356.x
   Kagota S, 2010, CLIN EXP PHARMACOL P, V37, P1035, DOI 10.1111/j.1440-1681.2010.05432.x
   Kagota S, 2009, J PHARMACOL SCI, V109, P556, DOI 10.1254/jphs.08273FP
   Laursen JB, 2001, CIRCULATION, V103, P1282
   Lavi S, 2008, HYPERTENSION, V51, P127, DOI 10.1161/HYPERTENSIONAHA.107.099986
   Looft-Wilson R.C., 2012, VASCUL PHARM, V58, P112
   Luo Z, 2009, BRIT J PHARMACOL, V157, P935, DOI 10.1111/j.1476-5381.2009.00259.x
   Marchesi C, 2009, HYPERTENSION, V54, P1384, DOI 10.1161/HYPERTENSIONAHA.109.138305
   Matsui H, 2008, HYPERTENSION, V52, P287, DOI 10.1161/HYPERTENSIONAHA.108.111815
   Mendizábal Y, 2011, AM J PHYSIOL-HEART C, V301, pH1319, DOI 10.1152/ajpheart.01280.2010
   Mount PF, 2007, J MOL CELL CARDIOL, V42, P271, DOI 10.1016/j.yjmcc.2006.05.023
   Nagase M, 2007, HYPERTENSION, V50, P877, DOI 10.1161/HYPERTENSIONAHA.107.091058
   Pfaffl MW, 2002, NUCLEIC ACIDS RES, V30, DOI 10.1093/nar/30.9.e36
   Pires PW, 2010, MICROVASC RES, V80, P445, DOI 10.1016/j.mvr.2010.06.004
   Rafikova O, 2008, METABOLISM, V57, P1434, DOI 10.1016/j.metabol.2008.05.014
   Raij Leopoldo, 2006, J Clin Hypertens (Greenwich), V8, P30, DOI 10.1111/j.1524-6175.2006.06025.x
   Rizzo NO, 2010, ARTERIOSCL THROM VAS, V30, P758, DOI 10.1161/ATVBAHA.109.199893
   Roberts CK, 2009, LIFE SCI, V84, P705, DOI 10.1016/j.lfs.2009.02.026
   Rosales MAB, 2010, INVEST OPHTH VIS SCI, V51, P4327, DOI 10.1167/iovs.09-4690
   Schmidt PM, 2005, EUR J PHARMACOL, V513, P67, DOI 10.1016/j.ejphar.2005.02.046
   Schmidt PM, 2004, J BIOL CHEM, V279, P3025, DOI 10.1074/jbc.M310141200
   Shishehbor MH, 2003, JAMA-J AM MED ASSOC, V289, P1675, DOI 10.1001/jama.289.13.1675
   Stasch JP, 2006, J CLIN INVEST, V116, P2552, DOI 10.1172/JCI28371
   Szabo C, 2009, BRIT J PHARMACOL, V156, P713, DOI 10.1111/j.1476-5381.2008.00086.x
   Umetani K, 2008, IEEE ENG MED BIO, P2693, DOI 10.1109/IEMBS.2008.4649757
   Vessières E, 2010, FRONT PHYSIOL, V1, DOI 10.3389/fphys.2010.00145
   Viswanad B, 2006, PHARMACOL RES, V53, P209, DOI 10.1016/j.phrs.2005.11.002
   Wang D, 2010, HYPERTENSION, V56, P950, DOI 10.1161/HYPERTENSIONAHA.110.157115
   Weber M, 2001, FREE RADICAL BIO MED, V31, P1360, DOI 10.1016/S0891-5849(01)00706-7
   Young EJ, 2008, DIABETOLOGIA, V51, P872, DOI 10.1007/s00125-008-0934-y
   Zou MH, 2002, J CLIN INVEST, V109, P817, DOI 10.1172/JCI200214442
NR 41
TC 13
Z9 15
U1 0
U2 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0026-2862
EI 1095-9319
J9 MICROVASC RES
JI Microvasc. Res.
PD JUL
PY 2013
VL 88
BP 70
EP 78
DI 10.1016/j.mvr.2013.04.001
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 239FI
UT WOS:000326007600010
PM 23571030
DA 2025-06-11
ER

PT J
AU Kang, SY
   Lee, JA
   Sunwoo, S
   Yu, BY
   Lee, JH
   Cho, CH
   Yoo, BW
   Jeon, TH
   Park, HK
   Kim, YS
AF Kang, Seo Young
   Lee, Jung Ah
   Sunwoo, Sung
   Yu, Byung-Yeon
   Lee, Jun Hyung
   Cho, Chung Hwan
   Yoo, Byung-wook
   Jeon, Tae Hee
   Park, Hoon Ki
   Kim, Young Sik
TI Prevalence of Sexual Dysfunction and Associated Risk Factors in
   Middle-Aged and Elderly Korean Men in Primary Care
SO JOURNAL OF SEX RESEARCH
LA English
DT Article
ID LATE-ONSET HYPOGONADISM; ERECTILE DYSFUNCTION; PREMATURE-EJACULATION;
   METABOLIC SYNDROME; ATTITUDES; OBESITY; DEPRESSION; DEFICIENCY; LIFE
AB Although several studies have individually investigated the risk factors for erectile dysfunction (ED), premature ejaculation (PE), and late-onset hypogonadism (LOH), few studies have considered ED, PE, and LOH as categories of sexual dysfunction (SD) within the same population. We therefore aimed to investigate the prevalence of SD and its associated risk factors among men in primary care. Study participants were enrolled by 18 family physicians from 15 hospital-based family practices in Korea between August 2010 and May 2011. Participants answered a questionnaire regarding their demographic characteristics and lifestyle factors as well as the Korean versions of the Androgen Deficiency in the Aging Male, the International Index of Erectile Function, and the Premature Ejaculation Diagnostic Tool questionnaires. SD prevalence was 64.9% among study participants who were 40years of age. ED prevalence was 43.7%, PE prevalence was 38.6%, and LOH prevalence was 16.8%. SD prevalence was significantly associated with increased age, overweight, hypertension, diabetes, and depression. These findings highlight the importance of screening questions for SD in primary care, especially among older male patients with the identified risk factors.
C1 [Kang, Seo Young; Lee, Jung Ah; Sunwoo, Sung; Kim, Young Sik] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Family Med, 88,Olymp Ro 43 Gil, Seoul 05505, South Korea.
   [Yu, Byung-Yeon] Konyang Univ, Coll Med, Konyang Univ Hosp, Dept Family Med, Nonsan, South Korea.
   [Lee, Jun Hyung] Inje Univ, Coll Med, Ilsan Paik Hosp, Dept Family Med, Gimhae, South Korea.
   [Cho, Chung Hwan] Jeonju Jesus Hosp, Dept Family Med, Jeonju, South Korea.
   [Yoo, Byung-wook] Soonchunhyang Univ, Coll Med, Soonchunhyang Univ Hosp Seoul, Dept Family Med, Asan, South Korea.
   [Jeon, Tae Hee] Cent Vet Hosp, Dept Family Med, Seoul, South Korea.
   [Park, Hoon Ki] Hanyang Univ, Coll Med, Hanyang Univ Hosp, Dept Family Med, Seoul, South Korea.
C3 University of Ulsan; Asan Medical Center; Konyang University; Konyang
   University Hospital; Inje University; Soonchunhyang University;
   Soonchunhyang University Hospital; Hanyang University; Hanyang
   University Hospital
RP Kim, YS (corresponding author), Univ Ulsan, Coll Med, Asan Med Ctr, Dept Family Med, 88,Olymp Ro 43 Gil, Seoul 05505, South Korea.
EM youngkim@amc.seoul.kr
OI Kang, Seo Young/0000-0002-7177-7816
FU Bayer Korea
FX This study was a follow-on study of the prevalence and correlates of
   late-onset hypogonadism among Korean men aged 40 years or older in
   primary care study. This study was supported in part by Bayer Korea.
CR Ahn TY, 2007, J SEX MED, V4, P1269, DOI 10.1111/j.1743-6109.2007.00554.x
   Ahn TY, 2001, Korean J Urol, V42, P535
   Albersen M, 2012, GERONTOLOGY, V58, P3, DOI 10.1159/000329598
   [Anonymous], 2000, ASIA PACIFIC PERSPEC
   Cho BL, 2003, INT J IMPOT RES, V15, P323, DOI 10.1038/sj.ijir.3901022
   Cho SY, 2012, J SEX MED, V9, P1550, DOI 10.1111/j.1743-6109.2012.02720.x
   Cohen P, 2009, ANDROLOGIA, V41, P205, DOI 10.1111/j.1439-0272.2009.00916.x
   Corona G, 2012, ASIAN J ANDROL, V14, P251, DOI 10.1038/aja.2011.138
   Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB
   DeRogatis LR, 2008, J SEX MED, V5, P289, DOI 10.1111/j.1743-6109.2007.00668.x
   Esposito K, 2008, INT J IMPOT RES, V20, P358, DOI 10.1038/ijir.2008.9
   Esposito K, 2011, CLIN PHARMACOL THER, V90, P169, DOI 10.1038/clpt.2011.91
   Gandaglia G, 2014, EUR UROL, V65, P968, DOI 10.1016/j.eururo.2013.08.023
   Guay A, 2010, INT J IMPOT RES, V22, P9, DOI 10.1038/ijir.2009.46
   Hwang HJ, 2013, J MENS HEALTH, V10, P146, DOI 10.1089/jomh.2013.1505
   감성철, 2009, The World Journal of Men's Health, V27, P185
   Kim Soo Woong, 2004, Investigative and Clinical Urology, V45, P674
   Lau JTF, 2005, INT J IMPOT RES, V17, P494, DOI 10.1038/sj.ijir.3901342
   Laumann EO, 2005, INT J IMPOT RES, V17, P39, DOI 10.1038/sj.ijir.3901250
   Laumann EO, 1999, JAMA-J AM MED ASSOC, V281, P537, DOI 10.1001/jama.281.6.537
   Lee SW, 2013, INT J IMPOT RES, V25, P12, DOI 10.1038/ijir.2012.27
   Lee SY, 2007, DIABETES RES CLIN PR, V75, P72, DOI 10.1016/j.diabres.2006.04.013
   Lee YC, 2012, J SEX MED, V9, P837, DOI 10.1111/j.1743-6109.2011.02588.x
   Liu CC, 2009, J SEX MED, V6, P936, DOI 10.1111/j.1743-6109.2008.01171.x
   Makhlouf AA, 2008, INT J IMPOT RES, V20, P157, DOI 10.1038/sj.ijir.3901576
   Neves D, 2013, FREE RADICAL RES, V47, P49, DOI 10.3109/10715762.2013.821701
   Oksuz E, 2005, INT J IMPOT RES, V17, P539, DOI 10.1038/sj.ijir.3901357
   Papatsoris AG, 2006, ANGIOLOGY, V57, P47, DOI 10.1177/000331970605700107
   Patrick DL, 2005, J SEX MED, V2, P358, DOI 10.1111/j.1743-6109.2005.20353.x
   Porst H, 2007, EUR UROL, V51, P816, DOI 10.1016/j.eururo.2006.07.004
   Read S, 1997, J PUBLIC HEALTH MED, V19, P387, DOI 10.1093/oxfordjournals.pubmed.a024665
   Rosen R C, 2000, Curr Psychiatry Rep, V2, P189, DOI 10.1007/s11920-996-0006-2
   Rosen RC, 2004, CURR MED RES OPIN, V20, P607, DOI 10.1185/030079904125003467
   Sanjay Saran, 2015, Indian J Endocrinol Metab, V19, P277, DOI 10.4103/2230-8210.149322
   Shabsigh R, 2008, INT J CLIN PRACT, V62, P791, DOI 10.1111/j.1742-1241.2008.01696.x
   Son H, 2011, J SEX MED, V8, P2062, DOI 10.1111/j.1743-6109.2010.02173.x
   Sugimori H, 2005, J SEX MED, V2, P390, DOI 10.1111/j.1743-6109.2005.20354.x
   Symonds T, 2007, EUR UROL, V52, P565, DOI 10.1016/j.eururo.2007.01.028
   Tan HM, 2012, J SEX MED, V9, P663, DOI 10.1111/j.1743-6109.2011.02582.x
   Tang WS, 2011, J SEX MED, V8, P2071, DOI 10.1111/j.1743-6109.2011.02280.x
   Wu FCW, 2010, NEW ENGL J MED, V363, P123, DOI 10.1056/NEJMoa0911101
   Zhang XS, 2013, BIOMED RES INT, V2013, DOI 10.1155/2013/317468
NR 42
TC 7
Z9 8
U1 0
U2 12
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0022-4499
EI 1559-8519
J9 J SEX RES
JI J. Sex Res.
PD NOV-DEC
PY 2016
VL 53
IS 9
BP 1165
EP 1178
DI 10.1080/00224499.2016.1174657
PG 14
WC Psychology, Clinical; Social Sciences, Interdisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology; Social Sciences - Other Topics
GA EA2ZG
UT WOS:000386465700011
PM 27215144
DA 2025-06-11
ER

PT J
AU Brogi, S
   Tabanelli, R
   Puca, S
   Calderone, V
AF Brogi, Simone
   Tabanelli, Rita
   Puca, Sara
   Calderone, Vincenzo
TI Intermittent Fasting: Myths, Fakes and Truth on This Dietary Regimen
   Approach
SO FOODS
LA English
DT Review
DE intermittent fasting (IF); alternate day fasting (ADF); time-restricted
   feeding (TRF); obesity; dietary regimen
ID DENSITY-LIPOPROTEIN CHOLESTEROL; RANDOMIZED CONTROLLED-TRIAL; TYPE-2
   DIABETES-MELLITUS; CALORIE-RESTRICTION; WEIGHT-LOSS; ALTERNATE-DAY;
   BODY-COMPOSITION; ENERGY RESTRICTION; COGNITIVE PERFORMANCE;
   BLOOD-CONSTITUENTS
AB Intermittent fasting (IF) has been indicated as a valuable alternative to the classical caloric restriction dietary regimen for lowering body weight and preventing obesity-related complications, such as metabolic syndrome and type II diabetes. However, is it effective? In this review article, we analyzed over 50 clinical studies in which IF, conducted by alternate day fasting (ADF) or time-restricted feeding (TRF), was compared with the caloric restriction approach. We evaluated the different roles of IF in treating and preventing human disorders such as metabolic syndrome, type II diabetes, and some types of cancer, as well as the usefulness of IF in reducing body weight and cardiovascular risk factors such as hypertension. Furthermore, we explored the cellular pathways targeted by IF to exert their beneficial effects by activating effector proteins that modulate cell functions and resistance to oxidative stress. In contrast, we investigated concerns regarding human health related to the adoption of IF dietary regimens, highlighting the profound debate surrounding weight loss regimens. We examined and compared several clinical trials to formulate an updated concept regarding IF and its therapeutic potential.
C1 [Brogi, Simone; Tabanelli, Rita; Puca, Sara; Calderone, Vincenzo] Univ Pisa, Dept Pharm, Via Bonanno 6, I-56126 Pisa, Italy.
   [Brogi, Simone] Isfahan Univ Med Sci, Bioinformat Res Ctr, Sch Pharm & Pharmaceut Sci, Esfahan 8174673461, Iran.
C3 University of Pisa; Isfahan University of Medical Sciences
RP Brogi, S (corresponding author), Univ Pisa, Dept Pharm, Via Bonanno 6, I-56126 Pisa, Italy.; Brogi, S (corresponding author), Isfahan Univ Med Sci, Bioinformat Res Ctr, Sch Pharm & Pharmaceut Sci, Esfahan 8174673461, Iran.
EM simone.brogi@unipi.it; ritatabanelli@gmail.com;
   saravictorlive@hotmail.it; vincenzo.calderone@unipi.it
RI Calderone, Vincenzo/L-9288-2015; Brogi, Simone/AAP-4179-2020
OI Brogi, Simone/0000-0001-9375-6242
CR abstractsonline, About Us
   Ahmed N, 2021, FRONT NUTR, V7, DOI 10.3389/fnut.2020.596787
   Alhamdan BA, 2016, OBES SCI PRACT, V2, P293, DOI 10.1002/osp4.52
   Alkurd R, 2024, MEDICINA-LITHUANIA, V60, DOI 10.3390/medicina60010191
   Anderson JW, 2001, AM J CLIN NUTR, V74, P579
   [Anonymous], About Us
   [Anonymous], ABOUT US
   Anson RM, 2003, P NATL ACAD SCI USA, V100, P6216, DOI 10.1073/pnas.1035720100
   Anton SD, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071500
   Anton SD, 2018, OBESITY, V26, P254, DOI 10.1002/oby.22065
   Arbesmann Rudolph., 1949, TRADITIO, V7, P1, DOI [10.1017/S0362152900015117, DOI 10.1017/S0362152900015117]
   Attinà A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051570
   Austad SN, 2024, FRONT AGING-LAUSANNE, V5, DOI 10.3389/fragi.2024.1393216
   Ballon A, 2019, J NUTR, V149, P106, DOI 10.1093/jn/nxy194
   Barati M, 2023, AUTOIMMUN REV, V22, DOI 10.1016/j.autrev.2023.103408
   Batitucci G, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.884305
   Beck A.T., 2011, APA PsycTests
   Berthelot E, 2021, NUTRIENTS, V13, DOI 10.3390/nu13113947
   Bhutani S, 2013, OBESITY, V21, P1370, DOI 10.1002/oby.20353
   bodenwelten, About Us
   Brandhorst S, 2015, CELL METAB, V22, P86, DOI 10.1016/j.cmet.2015.05.012
   Catenacci VA, 2016, OBESITY, V24, P1874, DOI 10.1002/oby.21581
   Chen SY, 2022, FRONT PUBLIC HEALTH, V10, DOI 10.3389/fpubh.2022.946795
   Cheung K, 2024, NUTRIENTS, V16, DOI 10.3390/nu16030357
   Cho AR, 2019, METABOLISM, V93, P52, DOI 10.1016/j.metabol.2019.01.002
   Ciccone L, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms232315105
   Cienfuegos S, 2022, NUTRIENTS, V14, DOI 10.3390/nu14112343
   Cienfuegos S, 2020, CELL METAB, V32, P366, DOI 10.1016/j.cmet.2020.06.018
   Conley M, 2018, NUTR DIET, V75, P65, DOI 10.1111/1747-0080.12372
   Cook F, 2022, CLIN NUTR ESPEN, V52, P257, DOI 10.1016/j.clnesp.2022.08.012
   Corley BT, 2018, DIABETIC MED, V35, P588, DOI 10.1111/dme.13595
   correiodoestado, About us
   cubacenter, About us
   Cui YS, 2020, FRONT NUTR, V7, DOI 10.3389/fnut.2020.586036
   Culletta G, 2024, EUR J MED CHEM, V270, DOI 10.1016/j.ejmech.2024.116355
   Dansinger ML, 2005, JAMA-J AM MED ASSOC, V293, P43, DOI 10.1001/jama.293.1.43
   Das SK, 2007, AM J CLIN NUTR, V85, P1023, DOI 10.1093/ajcn/85.4.1023
   de Cabo R, 2019, NEW ENGL J MED, V381, P2541, DOI 10.1056/NEJMra1905136
   de Toledo FW, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0209353
   Del Corral P, 2009, J CLIN ENDOCR METAB, V94, P1602, DOI 10.1210/jc.2008-1057
   Di Francesco A, 2018, SCIENCE, V362, P770, DOI 10.1126/science.aau2095
   Duan WZ, 2001, J MOL NEUROSCI, V16, P1, DOI 10.1385/JMN:16:1:1
   Elias A, 2023, NUTR REV, V81, P1225, DOI 10.1093/nutrit/nuad021
   Ellison RC, 1999, AM J EPIDEMIOL, V150, P910
   Eshghinia S, 2013, J DIABETES METAB DIS, V12, DOI 10.1186/2251-6581-12-4
   Ezpeleta M, 2023, CELL METAB, V35, P56, DOI 10.1016/j.cmet.2022.12.001
   Ezzati A, 2024, OBESITY, V32, P640, DOI 10.1002/oby.23984
   Fakhrzadeh H, 2003, ANN SAUDI MED, V23, P223, DOI 10.5144/0256-4947.2003.223
   Fang H, 2022, ANNU REV NUTR, V42, P201, DOI 10.1146/annurev-nutr-062320-111849
   FEDAIL SS, 1982, AM J CLIN NUTR, V36, P350, DOI 10.1093/ajcn/36.2.350
   Fernández-Rodríguez R, 2023, CRIT REV FOOD SCI, V63, P11169, DOI 10.1080/10408398.2022.2088687
   FIDANZA F, 1979, PROG FOOD NUTR SCI, V3, P79
   Flori L, 2021, EUR J PHARM SCI, V165, DOI 10.1016/j.ejps.2021.105930
   Fudla H., 2021, Obesity Medicine, V25, DOI [10.1016/j.obmed.2021.100353, DOI 10.1016/J.OBMED.2021.100353]
   Gabel K, 2019, OBESITY, V27, P1443, DOI 10.1002/oby.22564
   Gabel Kelsey, 2018, Nutr Healthy Aging, V4, P345, DOI 10.3233/NHA-170036
   Galassi FM, 2018, NEUROL SCI, V39, P939, DOI 10.1007/s10072-018-3285-6
   Gu LH, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.871682
   Gudden J, 2021, NUTRIENTS, V13, DOI 10.3390/nu13093166
   Guo Y, 2021, J CLIN ENDOCR METAB, V106, P64, DOI 10.1210/clinem/dgaa644
   Hajek P, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0258853
   Halberg N, 2005, J APPL PHYSIOL, V99, P2128, DOI 10.1152/japplphysiol.00683.2005
   Halpern B, 2021, ARCH ENDOCRIN METAB, V65, P14, DOI [10.20945/2359.3997000000322, 10.20945/2359-3997000000322]
   Hamer O, 2023, Br J Card Nurs, V18, DOI 10.12968/bjca.2023.0058
   Harris JC, 2014, JAMA PSYCHIAT, V71, P1212, DOI 10.1001/jamapsychiatry.2013.2765
   Heilbronn LK, 2003, AM J CLIN NUTR, V78, P361, DOI 10.1093/ajcn/78.3.361
   Heilbronn LK, 2005, OBES RES, V13, P574, DOI 10.1038/oby.2005.61
   Heilbronn LK, 2005, AM J CLIN NUTR, V81, P69
   Hoddy KK, 2020, OBESITY, V28, pS29, DOI 10.1002/oby.22829
   Hoddy KK, 2014, OBESITY, V22, P2524, DOI 10.1002/oby.20909
   Höhn S, 2019, EPILEPSY BEHAV, V94, P277, DOI 10.1016/j.yebeh.2019.03.018
   Horie NC, 2016, J CLIN ENDOCR METAB, V101, P1104, DOI 10.1210/jc.2015-2315
   Horne BD, 2015, AM J CLIN NUTR, V102, P464, DOI 10.3945/ajcn.115.109553
   Hsieh EA, 2005, AM J PHYSIOL-ENDOC M, V288, pE965, DOI 10.1152/ajpendo.00368.2004
   Hutchison AT, 2019, OBESITY, V27, P724, DOI 10.1002/oby.22449
   Hutchison AT, 2019, OBESITY, V27, P50, DOI 10.1002/oby.22345
   ilseme, about us
   Jack HomerA., 1994, The Gandhi Reader: A Sourcebook of His Life and Writings
   Jamshed H, 2022, JAMA INTERN MED, V182, P953, DOI 10.1001/jamainternmed.2022.3050
   Jensen MD, 2014, CIRCULATION, V129, pS102, DOI 10.1161/01.cir.0000437739.71477.ee
   Johnson SC, 2013, NATURE, V493, P338, DOI 10.1038/nature11861
   Kalam F, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010211
   Kalam F, 2019, OBES SCI PRACT, V5, P531, DOI 10.1002/osp4.367
   Kalyani RR, 2013, ENDOCRIN METAB CLIN, V42, P333, DOI 10.1016/j.ecl.2013.02.010
   Kang SM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027694
   Kashiwaya Y, 2013, NEUROBIOL AGING, V34, P1530, DOI 10.1016/j.neurobiolaging.2012.11.023
   Kelli HM, 2017, AM J CARDIOL, V120, P2289, DOI 10.1016/j.amjcard.2017.08.053
   KERNDT PR, 1982, WESTERN J MED, V137, P379
   Kim C, 2020, NUTRIENTS, V12, DOI 10.3390/nu12030638
   Kim J, 2023, OBESITY FACTS, V16, P69, DOI 10.1159/000527838
   Kim KK, 2022, J OBES METAB SYNDR, V31, P230, DOI 10.7570/jomes22050
   Kitada M, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9020130
   Klempel MC, 2013, EUR J CLIN NUTR, V67, P783, DOI 10.1038/ejcn.2013.83
   Kodama S, 2007, ARCH INTERN MED, V167, P999, DOI 10.1001/archinte.167.10.999
   Kritchevsky D, 2001, J NUTR SCI VITAMINOL, V47, P13, DOI 10.3177/jnsv.47.13
   Kroemer G, 2018, CELL, V175, P605, DOI 10.1016/j.cell.2018.07.044
   Kul S, 2014, J RELIG HEALTH, V53, P929, DOI 10.1007/s10943-013-9687-0
   Leclerc E, 2020, CNS SPECTRUMS, V25, P2, DOI 10.1017/S1092852918001566
   Leon AS, 2001, MED SCI SPORT EXER, V33, pS502, DOI 10.1097/00005768-200106001-00021
   Li CY, 2017, EXP CLIN ENDOCR DIAB, V125, P618, DOI 10.1055/s-0043-101700
   Lin SH, 2023, NUTRIENTS, V15, DOI 10.3390/nu15204313
   Lin SH, 2023, ANN INTERN MED, V176, P885, DOI 10.7326/M23-0052
   Lin SH, 2021, NUTR METAB CARDIOVAS, V31, P641, DOI 10.1016/j.numecd.2020.10.018
   Liu DY, 2022, NEW ENGL J MED, V386, P1495, DOI 10.1056/NEJMoa2114833
   Liu JH, 2023, J CLIN ENDOCR METAB, V108, P1824, DOI 10.1210/clinem/dgad036
   Longo VD, 2016, CELL METAB, V23, P1048, DOI 10.1016/j.cmet.2016.06.001
   Longo VD, 2014, CELL METAB, V19, P181, DOI 10.1016/j.cmet.2013.12.008
   Lowe DA, 2020, JAMA INTERN MED, V180, P1491, DOI 10.1001/jamainternmed.2020.4153
   Lynch S, 2021, NUTR BULL, V46, P69, DOI 10.1111/nbu.12479
   Maalouf M, 2009, BRAIN RES REV, V59, P293, DOI 10.1016/j.brainresrev.2008.09.002
   Macdonald G, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD001930.pub3
   Moreira EAM, 2011, NUTR CLIN PRACT, V26, P309, DOI 10.1177/0884533611405992
   MAISLOS M, 1993, AM J CLIN NUTR, V57, P640, DOI 10.1093/ajcn/57.5.640
   Manco M, 2005, CURR OPIN CLIN NUTR, V8, P431, DOI 10.1097/01.mco.0000172585.09762.8e
   Mattson MP, 2018, CELL METAB, V27, P1176, DOI 10.1016/j.cmet.2018.05.011
   Mattson MP, 2018, NAT REV NEUROSCI, V19, P81, DOI 10.1038/nrn.2017.156
   Mattson MP, 2017, AGEING RES REV, V39, P46, DOI 10.1016/j.arr.2016.10.005
   McCay CM, 1935, J NUTR, V10, P63, DOI 10.1093/jn/10.1.63
   MCCAY CM, 1989, NUTRITION, V5, P155
   McDonald RB, 2010, J NUTR, V140, P1205, DOI 10.3945/jn.110.122804
   McNair D.M., 2007, PROFILE MOOD STATES
   medcu, about us
   Menzies FM, 2017, NEURON, V93, P1015, DOI 10.1016/j.neuron.2017.01.022
   Meydani SN, 2016, AGING-US, V8, P1416, DOI 10.18632/aging.100994
   Minamiyama Y, 2007, J PHARMACOL EXP THER, V320, P535, DOI 10.1124/jpet.106.110460
   Moro T, 2016, J TRANSL MED, V14, DOI 10.1186/s12967-016-1044-0
   Mosley M., 2015, The FastDiet-Revised Updated: Lose Weight, Stay Healthy, and Live Longer with the Simple Secret of Intermittent Fasting
   Murta L, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms242115551
   Newman JC, 2017, CELL METAB, V26, P547, DOI 10.1016/j.cmet.2017.08.004
   newsroom heart, About us
   O'Connor SG, 2021, ADV NUTR, V12, P325, DOI 10.1093/advances/nmaa168
   Olsen T, 2024, J TRANSL MED, V22, DOI 10.1186/s12967-023-04833-w
   Ooi TC, 2020, NUTRIENTS, V12, DOI 10.3390/nu12092644
   Oswald J.A., 1989, Yours for Health: The Life and Times of Herbert M. Shelton
   Overland J., 2018, Obesity Medicine, V12, P13, DOI 10.1016/j.obmed.2018.11.001
   Pannen ST, 2021, NUTRIENTS, V13, DOI 10.3390/nu13041195
   Parvaresh A, 2019, COMPLEMENT THER MED, V47, DOI 10.1016/j.ctim.2019.08.021
   Pascual PE, 2023, OBESITY, V31, P9, DOI 10.1002/oby.23568
   Patel NV, 2005, NEUROBIOL AGING, V26, P995, DOI 10.1016/j.neurobiolaging.2004.09.014
   Patikorn C, 2021, JAMA NETW OPEN, V4, DOI 10.1001/jamanetworkopen.2021.39558
   Patterson RE, 2015, J ACAD NUTR DIET, V115, P1203, DOI 10.1016/j.jand.2015.02.018
   Pavlou V, 2023, JAMA NETW OPEN, V6, DOI 10.1001/jamanetworkopen.2023.39337
   Persynaki A, 2017, NUTRITION, V35, P14, DOI 10.1016/j.nut.2016.10.005
   Plaisance EP, 2011, J CLIN ENDOCR METAB, V96, pE836, DOI 10.1210/jc.2010-2493
   Rajpal A, 2020, DIABETES OBES METAB, V22, P1496, DOI [10.1111/dom.14080, 10.1111/dom.14080.]
   Ramadan J, 2002, MED PRIN PRACT, V11, P41, DOI 10.1159/000066413
   Richie JP Jr, 2023, J NUTR HEALTH AGING, V27, P111, DOI 10.1007/s12603-023-1883-3
   Roky R, 2001, J SLEEP RES, V10, P319, DOI 10.1046/j.1365-2869.2001.00269.x
   Rothschild J, 2014, NUTR REV, V72, P308, DOI 10.1111/nure.12104
   Rozing MP, 2010, J GERONTOL A-BIOL, V65, P365, DOI 10.1093/gerona/glp200
   Rynders CA, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102442
   Sacks FM, 2009, NEW ENGL J MED, V360, P859, DOI 10.1056/NEJMoa0804748
   Sadeghirad B, 2014, PUBLIC HEALTH NUTR, V17, P396, DOI 10.1017/S1368980012005046
   Sainsbury A, 2018, OBES REV, V19, P47, DOI 10.1111/obr.12787
   Santos HO, 2022, AM J CLIN NUTR, V115, P991, DOI 10.1093/ajcn/nqab433
   Sarraf-Zadegan N, 2000, ANN SAUDI MED, V20, P377, DOI 10.5144/0256-4947.2000.377
   Scarpulla RC, 2002, BBA-GENE STRUCT EXPR, V1576, P1, DOI 10.1016/S0167-4781(02)00343-3
   Schafer AL, 2016, J BONE MINER RES, V31, P36, DOI 10.1002/jbmr.2754
   Schmidt JA, 2016, EUR J CLIN NUTR, V70, P306, DOI 10.1038/ejcn.2015.144
   Schoonakker M.P., 2023, Visceral and Ectopic Fat. Risk Factors for Type 2 Diabetes, Atherosclerosis, and Cardiovascular Disease, P307, DOI [10.1016/B978-0-12-822186-0.00025-0, DOI 10.1016/B978-0-12-822186-0.00025-0]
   Schroor MM, 2024, ADV NUTR, V15, DOI 10.1016/j.advnut.2023.10.003
   Seidler K, 2022, FRONT NEUROENDOCRIN, V65, DOI 10.1016/j.yfrne.2021.100971
   Seimon RV, 2015, MOL CELL ENDOCRINOL, V418, P153, DOI 10.1016/j.mce.2015.09.014
   Senderovich H, 2023, MED PRIN PRACT, V32, P99, DOI 10.1159/000530269
   Sharifi S, 2024, PREV MED REP, V42, DOI 10.1016/j.pmedr.2024.102757
   Shelton H.M., 2013, The Science and Fine Art of Fasting
   Shelton H.M.G., 1996, Fasting Can Save Your Life
   Sievert K, 2019, BMJ-BRIT MED J, V364, DOI 10.1136/bmj.l42
   Skiadas PK, 2001, EUR J CLIN NUTR, V55, P532, DOI 10.1038/sj.ejcn.1601179
   Stekovic S, 2019, CELL METAB, V30, P462, DOI 10.1016/j.cmet.2019.07.016
   Stella A., 1975, Ann. Della Sc. Norm. Super. Pisa. Cl. Lett. E Filos, V5, P379
   Sundfor TM, 2018, NUTR METAB CARDIOVAS, V28, P698, DOI 10.1016/j.numecd.2018.03.009
   Sutton EF, 2018, CELL METAB, V27, P1212, DOI 10.1016/j.cmet.2018.04.010
   Taherzadeh-Fard E, 2011, MOL NEURODEGENER, V6, DOI 10.1186/1750-1326-6-32
   Tang DZ, 2016, J EXP MED, V213, P535, DOI 10.1084/jem.20151100
   Teong XT, 2021, NUTR RES, V92, P32, DOI 10.1016/j.nutres.2021.06.006
   Testai L, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/4650207
   Tinsley GM, 2015, NUTR REV, V73, P661, DOI 10.1093/nutrit/nuv041
   Trepanowski JF, 2018, CLIN NUTR, V37, P1871, DOI 10.1016/j.clnu.2017.11.018
   Trepanowski JF, 2017, JAMA INTERN MED, V177, P930, DOI 10.1001/jamainternmed.2017.0936
   Trepanowski JF, 2010, NUTR J, V9, DOI 10.1186/1475-2891-9-57
   Tsameret S, 2023, CELL MOL LIFE SCI, V80, DOI 10.1007/s00018-023-04834-4
   Varady KA, 2011, OBES REV, V12, pE593, DOI 10.1111/j.1467-789X.2011.00873.x
   Varady KA, 2007, AM J CLIN NUTR, V86, P7, DOI 10.1093/ajcn/86.1.7
   Varady KA, 2022, NAT REV ENDOCRINOL, V18, P309, DOI 10.1038/s41574-022-00638-x
   Varady KA, 2019, NAT REV ENDOCRINOL, V15, P686, DOI 10.1038/s41574-019-0270-y
   Varady KA, 2009, AM J CLIN NUTR, V90, P1138, DOI 10.3945/ajcn.2009.28380
   Varkaneh HK, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.948655
   Vasim I, 2022, NUTRIENTS, V14, DOI 10.3390/nu14030631
   Venegas-Borsellino Carla, 2018, Curr Nutr Rep, DOI 10.1007/s13668-018-0233-2
   Villareal DT, 2016, J BONE MINER RES, V31, P40, DOI 10.1002/jbmr.2701
   Visioli F, 2022, NUTRIENTS, V14, DOI 10.3390/nu14030433
   Wahl D, 2017, CLIN INTERV AGING, V12, P1419, DOI 10.2147/CIA.S145247
   Wang RH, 2024, NUTR REV, V83, pe412, DOI 10.1093/nutrit/nuae003
   Wang WH, 2022, NUTR METAB, V19, DOI 10.1186/s12986-022-00711-2
   Ware J.E., 1993, Health Inst, V6, P22
   washingtonpost, about us
   Waterlow J C, 1989, Eur J Clin Nutr, V43 Suppl 2, P3
   Wei M, 2017, SCI TRANSL MED, V9, DOI 10.1126/scitranslmed.aai8700
   Wen XY, 2024, FRONT NUTR, V11, DOI 10.3389/fnut.2024.1325894
   Wiersielis K, 2024, PHYSIOL BEHAV, V275, DOI 10.1016/j.physbeh.2023.114431
   Wingo BC, 2023, FRONT NEUROL, V13, DOI 10.3389/fneur.2022.1087126
   Witjaksono F, 2022, BMC RES NOTES, V15, DOI 10.1186/s13104-022-06209-7
   Witte AV, 2009, P NATL ACAD SCI USA, V106, P1255, DOI 10.1073/pnas.0808587106
   Youssef FF, 2008, NEUROSCI LETT, V431, P118, DOI 10.1016/j.neulet.2007.11.064
   Ziaee V., 2006, SMJ Singapore Medical Journal, V47, P409
NR 206
TC 4
Z9 4
U1 8
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD JUL
PY 2024
VL 13
IS 13
AR 1960
DI 10.3390/foods13131960
PG 44
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA YO9G2
UT WOS:001269538800001
PM 38998465
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Campisano, S
   La Colla, A
   Echarte, SM
   Chisari, AN
AF Campisano, Sabrina
   La Colla, Anabela
   Echarte, Stella M.
   Chisari, Andrea N.
TI Interplay between early-life malnutrition, epigenetic modulation of the
   immune function and liver diseases
SO NUTRITION RESEARCH REVIEWS
LA English
DT Review
DE Early malnutrition; Epigenetics; Immune response; Liver disease
ID HEPATIC STELLATE CELLS; TOLL-LIKE RECEPTORS; HIGH-FAT DIET; KAPPA-B
   ACTIVATION; NONALCOHOLIC STEATOHEPATITIS; HEPATOCELLULAR-CARCINOMA;
   DENDRITIC CELLS; DEVELOPMENTAL ORIGINS; SUPPRESSOR-CELLS; OXIDATIVE
   STRESS
AB Early-life nutrition plays a critical role in fetal growth and development. Food intake absence and excess are the two main types of energy malnutrition that predispose to the appearance of diseases in adulthood, according to the hypothesis of 'developmental origins of health and disease'. Epidemiological data have shown an association between early-life malnutrition and the metabolic syndrome in later life. Evidence has also demonstrated that nutrition during this period of life can affect the development of the immune system through epigenetic mechanisms. Thus, epigenetics has an essential role in the complex interplay between environmental factors and genetics. Altogether, this leads to the inflammatory response that is commonly seen in non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome. In conjunction, DNA methylation, covalent modification of histones and the expression of non-coding RNA are the epigenetic phenomena that affect inflammatory processes in the context of NAFLD. Here, we highlight current understanding of the mechanisms underlying developmental programming of NAFLD linked to epigenetic modulation of the immune system and environmental factors, such as malnutrition.
C1 [Campisano, Sabrina; La Colla, Anabela; Echarte, Stella M.; Chisari, Andrea N.] Univ Nacl Mar Del Plata, Dept Quim, Fac Ciencias Exactas & Nat, RA-7600 Mar Del Plata, Buenos Aires, Argentina.
C3 National University of Mar del Plata
RP Chisari, AN (corresponding author), Univ Nacl Mar Del Plata, Dept Quim, Fac Ciencias Exactas & Nat, RA-7600 Mar Del Plata, Buenos Aires, Argentina.
EM achisari@mdp.edu.ar
OI Chisari, Andrea/0000-0001-9351-0138
CR Aagaard-Tillery KM, 2008, J MOL ENDOCRINOL, V41, P91, DOI 10.1677/JME-08-0025
   Abiru S, 2006, LIVER INT, V26, P39, DOI 10.1111/j.1478-3231.2005.01191.x
   Abu-Farha M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0075342
   Ahrens M, 2013, CELL METAB, V18, P296, DOI 10.1016/j.cmet.2013.07.004
   Albano E, 2005, GUT, V54, P987, DOI 10.1136/gut.2004.057968
   Amodio N, 2013, CELL CYCLE, V12, P3650, DOI 10.4161/cc.26585
   Anderson OS, 2012, J NUTR BIOCHEM, V23, P853, DOI 10.1016/j.jnutbio.2012.03.003
   Aoyama T, 2010, GASTROENT RES PRACT, V2010, DOI 10.1155/2010/192543
   Arner E, 2012, DIABETES, V61, P1986, DOI 10.2337/db11-1508
   Balasubramanyam M, 2011, MOL CELL BIOCHEM, V351, P197, DOI 10.1007/s11010-011-0727-3
   Barker DJP, 2004, ACTA PAEDIATR, V93, P26, DOI 10.1080/08035320410022730
   Barker DJP, 2002, INT J EPIDEMIOL, V31, P1235, DOI 10.1093/ije/31.6.1235
   Barres R, 2013, CELL REP, V3, P1020, DOI 10.1016/j.celrep.2013.03.018
   Bartz S, 2014, J CLIN ENDOCR METAB, V99, P2128, DOI 10.1210/jc.2013-4018
   Bernsmeier C, 2017, J HEPATOL, V66, P1120, DOI 10.1016/j.jhep.2017.02.018
   Bhattacharjee J, 2014, J NUTR BIOCHEM, V25, P219, DOI 10.1016/j.jnutbio.2013.10.010
   Bilzer M, 2006, LIVER INT, V26, P1175, DOI 10.1111/j.1478-3231.2006.01342.x
   Biswas SK, 2012, CELL METAB, V15, P432, DOI 10.1016/j.cmet.2011.11.013
   Black RE, 2003, LANCET, V361, P2226, DOI 10.1016/S0140-6736(03)13779-8
   Boelte KC, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0018534
   Boney CM, 2005, PEDIATRICS, V115, pE290, DOI 10.1542/peds.2004-1808
   Bonizzi G, 2004, TRENDS IMMUNOL, V25, P280, DOI 10.1016/j.it.2004.03.008
   Boujedidi H, 2015, CLIN SCI, V128, P257, DOI 10.1042/CS20130833
   Bricambert J, 2010, J CLIN INVEST, V120, P4316, DOI 10.1172/JCI41624
   Brumbaugh DE, 2014, PEDIATR RES, V75, P140, DOI 10.1038/pr.2013.193
   Brunt EM, 2010, NAT REV GASTRO HEPAT, V7, P195, DOI 10.1038/nrgastro.2010.21
   Byrne CD, 2015, J HEPATOL, V62, pS47, DOI 10.1016/j.jhep.2014.12.012
   Cao R, 2002, SCIENCE, V298, P1039, DOI 10.1126/science.1076997
   Cermelli S, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023937
   Chen G, 2015, MOL NUTR FOOD RES, V59, P293, DOI 10.1002/mnfr.201400483
   Chen S, 2011, CLIN EXP IMMUNOL, V166, P134, DOI 10.1111/j.1365-2249.2011.04445.x
   Cheng C, 2014, TOXICOL LETT, V225, P488, DOI 10.1016/j.toxlet.2013.12.023
   Cheung O, 2008, HEPATOLOGY, V48, P1810, DOI 10.1002/hep.22569
   Chiba M, 2011, J CLIN PATHOL, V64, P564, DOI 10.1136/jcp.2011.090175
   Chou HS, 2011, HEPATOLOGY, V53, P1007, DOI 10.1002/hep.24162
   Cianfarani S, 2012, INT J OBESITY, V36, P1270, DOI 10.1038/ijo.2012.54
   Colak Y, 2014, J GASTROINTEST LIVER, V23, P311, DOI [10.1543/jgld.20l4.1121.233.yck, 10.15403/jgld.2014.1121.233.yck]
   Colak Y, 2011, MED SCI MONITOR, V17, pHY5, DOI 10.12659/MSM.881749
   Correia-Branco A, 2015, REPROD SCI, V22, P138, DOI 10.1177/1933719114542012
   Crispe IN, 2009, ANNU REV IMMUNOL, V27, P147, DOI 10.1146/annurev.immunol.021908.132629
   Csak T, 2011, HEPATOLOGY, V54, P133, DOI 10.1002/hep.24341
   Csak T, 2011, AM J PHYSIOL-GASTR L, V300, pG433, DOI 10.1152/ajpgi.00163.2009
   Dietrich P, 2014, BEST PRACT RES CL GA, V28, P637, DOI 10.1016/j.bpg.2014.07.008
   DiSpirito JR, 2010, J IMMUNOL, V184, P4631, DOI 10.4049/jimmunol.0903830
   Dixon LJ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0056100
   Doherty DG, 2016, J AUTOIMMUN, V66, P60, DOI 10.1016/j.jaut.2015.08.020
   Donkin I, 2016, CELL METAB, V23, P369, DOI 10.1016/j.cmet.2015.11.004
   Dranoff JA, 2002, HEPATOLOGY, V36, P1135, DOI 10.1053/jhep.2002.36823
   Dudley KJ, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0021662
   Dutertre CA, 2014, CELL IMMUNOL, V291, P3, DOI 10.1016/j.cellimm.2014.08.006
   Eckert C, 2015, FRONT IMMUNOL, V6, DOI 10.3389/fimmu.2015.00179
   Ekihiro S, 2008, HEPATOLOGY, V48, P322, DOI [10.1002/hep.22306, DOI 10.1002/HEP.22306]
   Ekstedt M, 2006, HEPATOLOGY, V44, P865, DOI 10.1002/hep.21327
   Elpek GO, 2014, WORLD J GASTROENTERO, V20, P7260, DOI 10.3748/wjg.v20.i23.7260
   Escande C, 2010, J CLIN INVEST, V120, P545, DOI 10.1172/JCI39319
   Estep M, 2010, ALIMENT PHARM THER, V32, P487, DOI 10.1111/j.1365-2036.2010.04366.x
   Inzaugarat ME, 2011, J CLIN IMMUNOL, V31, P1120, DOI 10.1007/s10875-011-9571-1
   Farazi PA, 2006, NAT REV CANCER, V6, P674, DOI 10.1038/nrc1934
   Feige JN, 2008, CURR OPIN CELL BIOL, V20, P303, DOI 10.1016/j.ceb.2008.03.012
   Feng D, 2011, SCIENCE, V331, P1315, DOI 10.1126/science.1198125
   Ferreira DMS, 2014, FEBS J, V281, P2503, DOI 10.1111/febs.12806
   Finch ML, 2014, INT J BIOCHEM CELL B, V54, P288, DOI 10.1016/j.biocel.2014.04.002
   Foley NH, 2012, J LEUKOCYTE BIOL, V92, P521, DOI 10.1189/jlb.0312160
   Franco R, 2008, CANCER LETT, V266, P6, DOI 10.1016/j.canlet.2008.02.026
   Fraser A, 2008, PAEDIATR PERINAT EP, V22, P12, DOI 10.1111/j.1365-3016.2007.00876.x
   Gabrilovich DI, 2009, NAT REV IMMUNOL, V9, P162, DOI 10.1038/nri2506
   Gallagher EJ, 2011, ENDOCRINOLOGY, V152, P2546, DOI 10.1210/en.2011-0231
   Gallego-Durán R, 2015, WORLD J HEPATOL, V7, P2497, DOI 10.4254/wjh.v7.i24.2497
   Ganz M, 2013, HEPATOL INT, V7, pS771, DOI 10.1007/s12072-013-9468-6
   Gatselis NK, 2014, CLIN EXP MED, V14, P121, DOI 10.1007/s10238-012-0227-0
   Giby VG, 2014, WORLD J HEPATOL, V6, P570, DOI 10.4254/wjh.v6.i8.570
   Gillum MP, 2011, DIABETES, V60, P3235, DOI 10.2337/db11-0616
   Gluckman PD, 2004, TRENDS ENDOCRIN MET, V15, P183, DOI 10.1016/j.tem.2004.03.002
   Gong L, 2010, EPIGENETICS-US, V5, P619, DOI 10.4161/epi.5.7.12882
   Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
   Guéant JL, 2013, TRENDS ENDOCRIN MET, V24, P279, DOI 10.1016/j.tem.2013.01.010
   Guy CD, 2012, HEPATOLOGY, V55, P1711, DOI 10.1002/hep.25559
   Hagemann T, 2008, J EXP MED, V205, P1261, DOI 10.1084/jem.20080108
   Hale M, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0118784
   HALES CN, 1992, DIABETOLOGIA, V35, P595, DOI 10.1093/ije/dyt133
   Hammerich Linda, 2015, World J Gastrointest Pathophysiol, V6, P43, DOI 10.4291/wjgp.v6.i3.43
   Han MS, 2013, SCIENCE, V339, P218, DOI 10.1126/science.1227568
   Harada K, 2003, LAB INVEST, V83, P1657, DOI 10.1097/01.LAB.0000097190.56734.FE
   Haukeland JW, 2006, J HEPATOL, V44, P1167, DOI 10.1016/j.jhep.2006.02.011
   Heier EC, 2017, J HEPATOL, V66, P1241, DOI 10.1016/j.jhep.2017.01.008
   Heijmans BT, 2008, P NATL ACAD SCI USA, V105, P17046, DOI 10.1073/pnas.0806560105
   Henning JR, 2013, HEPATOLOGY, V58, P589, DOI 10.1002/hep.26267
   Herath NI, 2006, J GASTROEN HEPATOL, V21, P15, DOI 10.1111/j.1440-1746.2005.04043.x
   Hermsdorff HH, 2013, CYTOKINE, V64, P265, DOI 10.1016/j.cyto.2013.05.028
   Herranz D, 2010, NAT REV CANCER, V10, P819, DOI 10.1038/nrc2962
   Herranz D, 2010, NAT COMMUN, V1, DOI 10.1038/ncomms1001
   Heymann F, 2016, NAT REV GASTRO HEPAT, V13, P88, DOI 10.1038/nrgastro.2015.200
   Hirschey MD, 2011, MOL CELL, V44, P177, DOI 10.1016/j.molcel.2011.07.019
   Höchst B, 2013, J HEPATOL, V59, P528, DOI 10.1016/j.jhep.2013.04.033
   Hsieh CC, 2013, BLOOD, V121, P1760, DOI 10.1182/blood-2012-06-440214
   Hsu SH, 2012, J CLIN INVEST, V122, P2871, DOI 10.1172/JCI63539
   Huang B, 2007, CANCER LETT, V252, P86, DOI 10.1016/j.canlet.2006.12.012
   Hulsmans M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0032794
   Hulsmans M, 2011, FASEB J, V25, P2515, DOI 10.1096/fj.11-181149
   Ibrahim J, 2012, GASTROENTEROLOGY, V143, P1061, DOI 10.1053/j.gastro.2012.06.003
   Iimuro Y, 2010, GASTROENT RES PRACT, V2010, DOI 10.1155/2010/598109
   Jang Hyeran, 2014, Clin Nutr Res, V3, P1, DOI 10.7762/cnr.2014.3.1.1
   Jo EK, 2016, CELL MOL IMMUNOL, V13, P148, DOI 10.1038/cmi.2015.95
   Pirola CJ, 2013, GUT, V62, P1356, DOI 10.1136/gutjnl-2012-302962
   Kawasaki K, 2013, LAB INVEST, V93, P311, DOI 10.1038/labinvest.2012.176
   Kelly A, 2014, J HEPATOL, V60, P135, DOI 10.1016/j.jhep.2013.08.007
   Kim DH, 2015, EXP MOL MED, V47, DOI 10.1038/emm.2014.98
   Kim HS, 2010, CANCER CELL, V17, P41, DOI 10.1016/j.ccr.2009.11.023
   Kobold D, 2002, J HEPATOL, V36, P607, DOI 10.1016/S0168-8278(02)00050-8
   Krizhanovsky V, 2008, CELL, V134, P657, DOI 10.1016/j.cell.2008.06.049
   Lahtz C, 2011, J MOL CELL BIOL, V3, P51, DOI 10.1093/jmcb/mjq053
   Lakner AM, 2011, WORLD J GASTROENTERO, V17, P2536, DOI 10.3748/wjg.v17.i20.2536
   Lawrence T, 2007, INT J EXP PATHOL, V88, P85, DOI 10.1111/j.1365-2613.2006.00507.x
   Lee JH, 2014, NUTRIENTS, V6, P3303, DOI 10.3390/nu6083303
   Li Y, 2008, J BIOL CHEM, V283, P26771, DOI 10.1074/jbc.M802800200
   Liao YJ, 2009, INT J CANCER, V124, P816, DOI 10.1002/ijc.23979
   Lillycrop KA, 2008, BRIT J NUTR, V100, P278, DOI 10.1017/S0007114507894438
   Ling C, 2009, DIABETES, V58, P2718, DOI 10.2337/db09-1003
   Liu SB, 2002, INFECT IMMUN, V70, P3433, DOI 10.1128/IAI.70.7.3433-3442.2002
   Liu Y, 2013, CANCER RES, V73, P550, DOI 10.1158/0008-5472.CAN-12-2290
   Lleo A, 2013, DIGEST LIVER DIS, V45, P630, DOI 10.1016/j.dld.2013.01.005
   Lu SC, 2001, P NATL ACAD SCI USA, V98, P5560, DOI 10.1073/pnas.091016398
   Lu SC, 2012, PHYSIOL REV, V92, P1515, DOI 10.1152/physrev.00047.2011
   Lynn FC, 2009, TRENDS ENDOCRIN MET, V20, P452, DOI 10.1016/j.tem.2009.05.007
   Machado M, 2006, J HEPATOL, V45, P600, DOI 10.1016/j.jhep.2006.06.013
   Malhi H, 2006, J BIOL CHEM, V281, P12093, DOI 10.1074/jbc.M510660200
   Mann J, 2010, GASTROENTEROLOGY, V138, P705, DOI 10.1053/j.gastro.2009.10.002
   Martínez D, 2014, CELL METAB, V19, P941, DOI 10.1016/j.cmet.2014.03.026
   Martinez FO, 2009, ANNU REV IMMUNOL, V27, P451, DOI 10.1146/annurev.immunol.021908.132532
   Martínez-Chantar ML, 2008, HEPATOLOGY, V47, P1191, DOI 10.1002/hep.22159
   Martínez-Chantar ML, 2002, FASEB J, V16, P1292, DOI 10.1096/fj.02-0078fje
   Matsumura T, 2003, IMMUNOLOGY, V109, P127, DOI 10.1046/j.1365-2567.2003.01627.x
   Mazzoccoli G, 2014, LIVER INT, V34, P1133, DOI 10.1111/liv.12534
   Meng FL, 2012, GASTROENTEROLOGY, V143, P765, DOI 10.1053/j.gastro.2012.05.049
   Meng FY, 2007, GASTROENTEROLOGY, V133, P647, DOI 10.1053/j.gastro.2007.05.022
   Miao F, 2004, J BIOL CHEM, V279, P18091, DOI 10.1074/jbc.M311786200
   Mikula M, 2014, INT J MOL MED, V34, P1647, DOI 10.3892/ijmm.2014.1958
   Mirza M S, 2011, ISRN Gastroenterol, V2011, P592404, DOI 10.5402/2011/592404
   Miura K, 2013, HEPATOLOGY, V57, P577, DOI 10.1002/hep.26081
   Miura K, 2010, GASTROENTEROLOGY, V139, P323, DOI 10.1053/j.gastro.2010.03.052
   Murphy SK, 2013, GASTROENTEROLOGY, V145, P1076, DOI 10.1053/j.gastro.2013.07.047
   Niculescu MD, 2002, J NUTR, V132, p2333S, DOI 10.1093/jn/132.8.2333S
   Nobili V, 2010, INT J MOL MED, V26, P471, DOI 10.3892/ijmm_00000487
   Norris S, 1998, J HEPATOL, V28, P84, DOI 10.1016/S0168-8278(98)80206-7
   Pallett LJ, 2015, NAT MED, V21, P591, DOI 10.1038/nm.3856
   Panera N, 2014, WORLD J GASTROENTERO, V20, P15079, DOI 10.3748/wjg.v20.i41.15079
   Paparo L, 2014, NUTRIENTS, V6, P4706, DOI 10.3390/nu6114706
   Pardee PE, 2009, SEMIN PEDIATR SURG, V18, P144, DOI 10.1053/j.sempedsurg.2009.04.004
   Park EJ, 2010, CELL, V140, P197, DOI 10.1016/j.cell.2009.12.052
   Paz K, 1997, J BIOL CHEM, V272, P29911, DOI 10.1074/jbc.272.47.29911
   Pedra JHF, 2009, CURR OPIN IMMUNOL, V21, P10, DOI 10.1016/j.coi.2009.01.006
   PETTITT DJ, 1983, NEW ENGL J MED, V308, P242, DOI 10.1056/NEJM198302033080502
   Pogribny IP, 2010, LAB INVEST, V90, P1437, DOI 10.1038/labinvest.2010.113
   Portha B, 2014, BIOCHIMIE, V97, P1, DOI 10.1016/j.biochi.2013.10.003
   Pruis MGM, 2014, ACTA PHYSIOL, V210, P215, DOI 10.1111/apha.12197
   PRUVOT FR, 1995, TRANSPLANT INT, V8, P273, DOI 10.1111/j.1432-2277.1995.tb01521.x
   Purushotham A, 2009, CELL METAB, V9, P327, DOI 10.1016/j.cmet.2009.02.006
   Radaeva S, 2007, AM J PHYSIOL-GASTR L, V293, pG809, DOI 10.1152/ajpgi.00212.2007
   Rahman AH, 2013, BBA-MOL BASIS DIS, V1832, P998, DOI 10.1016/j.bbadis.2013.01.005
   Ramadori G, 2004, LAB INVEST, V84, P153, DOI 10.1038/labinvest.3700030
   Rau M, 2016, J IMMUNOL, V196, P97, DOI 10.4049/jimmunol.1501175
   Ravelli ACJ, 1999, AM J CLIN NUTR, V70, P811
   Reamon-Buettner SM, 2014, REPROD TOXICOL, V45, P117, DOI 10.1016/j.reprotox.2014.02.009
   Reddy MA, 2014, DIABETES, V63, P4249, DOI 10.2337/db14-0298
   Rivera CA, 2010, BMC GASTROENTEROL, V10, DOI 10.1186/1471-230X-10-52
   Robinson MW, 2016, CELL MOL IMMUNOL, V13, P267, DOI 10.1038/cmi.2016.3
   ROMAGNANI S, 1991, INT J CLIN LAB RES, V21, P152
   Roseboom T, 2006, EARLY HUM DEV, V82, P485, DOI 10.1016/j.earlhumdev.2006.07.001
   Ross MG, 2008, SEMIN PERINATOL, V32, P213, DOI 10.1053/j.semperi.2007.11.005
   Schieferdecker HL, 2001, INT IMMUNOPHARMACOL, V1, P469, DOI 10.1016/S1567-5769(00)00038-2
   Schneider C, 2012, GUT, V61, P1733, DOI 10.1136/gutjnl-2011-301116
   Schoenborn JR, 2007, NAT IMMUNOL, V8, P732, DOI 10.1038/ni1474
   Seki E, 2008, HEPATOLOGY, V48, P322, DOI 10.1002/hep.22306
   Seki E, 2007, NAT MED, V13, P1324, DOI 10.1038/nm1663
   Sell H, 2012, NAT REV ENDOCRINOL, V8, P709, DOI 10.1038/nrendo.2012.114
   Shankar K, 2008, AM J PHYSIOL-REG I, V294, pR528, DOI 10.1152/ajpregu.00316.2007
   Sica A, 2012, J CLIN INVEST, V122, P787, DOI 10.1172/JCI59643
   Simar D, 2014, METABOLISM, V63, P1188, DOI 10.1016/j.metabol.2014.05.014
   Singer Cristina, 2014, Curr Health Sci J, V40, P170, DOI 10.12865/CHSJ.40.03.03
   SMEDSROD B, 1994, GUT, V35, P1509, DOI 10.1136/gut.35.11.1509
   Sookoian S, 2010, HEPATOLOGY, V52, P1992, DOI 10.1002/hep.23927
   Spruss A, 2009, HEPATOLOGY, V50, P1094, DOI 10.1002/hep.23122
   Stickel F, 2010, GUT, V59, P1303, DOI 10.1136/gut.2009.199661
   Su GL, 2000, HEPATOLOGY, V31, P932, DOI 10.1053/he.2000.5634
   Sun C, 2015, INT J MOL SCI, V16, P5161, DOI 10.3390/ijms16035161
   Suter MA, 2012, FASEB J, V26, P5106, DOI 10.1096/fj.12-212878
   Sutti S, 2014, HEPATOLOGY, V59, P886, DOI 10.1002/hep.26749
   Syn WK, 2012, GUT, V61, P1323, DOI 10.1136/gutjnl-2011-301857
   Takeda N, 2010, GENE DEV, V24, P491, DOI 10.1101/gad.1881410
   Tan ZM, 2013, J IMMUNOL, V191, P1835, DOI 10.4049/jimmunol.1203013
   Tang Y, 2011, CLIN EXP IMMUNOL, V166, P281, DOI 10.1111/j.1365-2249.2011.04471.x
   Tessitore A, 2016, BMC CANCER, V16, DOI 10.1186/s12885-015-2007-1
   Thapa M, 2015, HEPATOLOGY, V61, P2067, DOI 10.1002/hep.27761
   Thomson AW, 2010, NAT REV IMMUNOL, V10, P753, DOI 10.1038/nri2858
   Tian WF, 2013, HEPATOLOGY, V58, P576, DOI 10.1002/hep.26207
   Tian Y, 2013, SEMIN CANCER BIOL, V23, P471, DOI 10.1016/j.semcancer.2013.08.010
   Tian ZG, 2013, HEPATOLOGY, V57, P1654, DOI 10.1002/hep.26115
   Tryndyak VP, 2012, TOXICOL APPL PHARM, V262, P52, DOI 10.1016/j.taap.2012.04.018
   Tsai WC, 2012, J CLIN INVEST, V122, P2884, DOI 10.1172/JCI63455
   Uhrig A, 2005, J LEUKOCYTE BIOL, V77, P626, DOI 10.1189/jlb.0604332
   van Egmond M, 2000, NAT MED, V6, P680, DOI 10.1038/76261
   Varga T, 2011, BBA-MOL BASIS DIS, V1812, P1007, DOI 10.1016/j.bbadis.2011.02.014
   Vella S, 2013, INT J MOL SCI, V14, P24154, DOI 10.3390/ijms141224154
   Victora CG, 2008, LANCET, V371, P340, DOI 10.1016/S0140-6736(07)61692-4
   Vinciguerra M, 2009, J HEPATOL, V50, P1132, DOI 10.1016/j.jhep.2009.01.027
   Vinciguerra M, 2009, HEPATOLOGY, V49, P1176, DOI 10.1002/hep.22737
   Viré E, 2006, NATURE, V439, P871, DOI 10.1038/nature04431
   Wan JH, 2014, HEPATOLOGY, V59, P130, DOI 10.1002/hep.26607
   Wang B, 2009, HEPATOLOGY, V50, P1152, DOI 10.1002/hep.23100
   Wang NJ, 2017, CLIN NUTR, V36, P253, DOI 10.1016/j.clnu.2015.11.010
   Wang NJ, 2016, J CLIN ENDOCR METAB, V101, P2218, DOI 10.1210/jc.2016-1076
   Wang NJ, 2015, J CLIN ENDOCR METAB, V100, P4514, DOI 10.1210/jc.2015-2750
   Wang RH, 2008, CANCER CELL, V14, P312, DOI 10.1016/j.ccr.2008.09.001
   Wang XL, 2010, BMC MED, V8, DOI 10.1186/1741-7015-8-87
   Wang ZF, 2013, CANCER LETT, V331, P1, DOI 10.1016/j.canlet.2012.12.006
   Wehr A, 2013, J IMMUNOL, V190, P5226, DOI 10.4049/jimmunol.1202909
   Wei YR, 2006, AM J PHYSIOL-ENDOC M, V291, pE275, DOI 10.1152/ajpendo.00644.2005
   Weiskirchen Ralf, 2014, Hepatobiliary Surg Nutr, V3, P344, DOI 10.3978/j.issn.2304-3881.2014.11.03
   Wen J, 2012, J CLIN INVEST, V122, P2773, DOI 10.1172/JCI63966
   Whitaker RC, 2004, PEDIATRICS, V114, pE29, DOI 10.1542/peds.114.1.e29
   Winer DA, 2011, NAT MED, V17, P610, DOI 10.1038/nm.2353
   Wolf MJ, 2014, CANCER CELL, V26, P549, DOI 10.1016/j.ccell.2014.09.003
   Worm J, 2009, NUCLEIC ACIDS RES, V37, P5784, DOI 10.1093/nar/gkp577
   Wu J, 2010, IMMUNOLOGY, V129, P363, DOI 10.1111/j.1365-2567.2009.03179.x
   Wu SD, 2012, CANCER TREAT REV, V38, P218, DOI 10.1016/j.ctrv.2011.06.010
   Yan XL, 2013, HEPATOLOGY, V57, P2274, DOI 10.1002/hep.26257
   Yang XS, 2014, MOL ENDOCRINOL, V28, P565, DOI 10.1210/me.2013-1293
   Yao LY, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0149948
   Yen BLJ, 2013, STEM CELL REP, V1, P139, DOI 10.1016/j.stemcr.2013.06.006
   Younossi ZM, 2004, CLIN GASTROENTEROL H, V2, P262, DOI 10.1016/S1542-3565(04)00014-X
   Younossi ZM, 2011, CLIN GASTROENTEROL H, V9, P524, DOI 10.1016/j.cgh.2011.03.020
   Zeybel M, 2012, NAT MED, V18, P1369, DOI 10.1038/nm.2893
   Zhang JL, 2009, BMC GENOMICS, V10, DOI 10.1186/1471-2164-10-478
   Zhou YL, 2014, MOL CELL ENDOCRINOL, V386, P16, DOI 10.1016/j.mce.2013.09.006
NR 234
TC 39
Z9 40
U1 0
U2 28
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0954-4224
EI 1475-2700
J9 NUTR RES REV
JI Nutr. Res. Rev.
PD JUN
PY 2019
VL 32
IS 1
BP 128
EP 145
DI 10.1017/S0954422418000239
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HX5HU
UT WOS:000467432600008
PM 30707092
OA Green Published
DA 2025-06-11
ER

PT J
AU Li, Z
   Miard, S
   Laplante, M
   Sonenberg, N
   Picard, F
AF Li, Zhuo
   Miard, Stephanie
   Laplante, Mathieu
   Sonenberg, Nahum
   Picard, Frederic
TI Insulin stimulates IGFBP-2 expression in 3T3-L1 adipocytes through the
   PI3K/mTOR pathway
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article
DE Mouse; 3T3-L1; mTOR; Gene expression; Chromatin immunoprecipitation;
   C/EBP alpha
ID FACTOR-BINDING PROTEIN-2; DIET-INDUCED OBESITY; MTOR COMPLEX 1; I IGF-I;
   ADIPOSE-TISSUE; CELLULAR-DISTRIBUTION; HORMONAL-REGULATION; METABOLIC
   SYNDROME; OXIDATIVE STRESS; MESSENGER-RNAS
AB Insulin-like growth factor binding protein 2 (IGFBP-2) has been implicated in the etiology of several diseases, including the metabolic syndrome. Although IGFBP-2 derives mostly from the liver, recent evidence in mice and humans indicate that aging and obesity are associated with altered IGFBP-2 levels in white adipocytes. The present study was aimed at determining the mechanisms that control IGFBP-2 expression in mature adipocytes. IGFBP-2 mRNA and protein expression in serum-deprived 3T3-L1 adipocytes were twofold increased by acute insulin treatment. Co-treatments with the phosphatidylinositol 3-kinase (PI3K) inhibitor wortmannin or the mammalian target of rapamycin (mTOR) inhibitor rapamycin blunted the effects of insulin. Coherently, IGFBP-2 mRNA levels were robustly increased in adipocytes lacking either TSC2 or 4E-BP1. Insulin triggered the recruitment of CAAT/enhancer binding protein alpha (C/EBP alpha) to the IGFBP-2 proximal promoter. These findings suggest that insulin upregulates IGFBP-2 expression through a PI3K/mTOR/C/EBP alpha pathway in white adipocytes. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
C1 [Li, Zhuo; Miard, Stephanie; Laplante, Mathieu; Picard, Frederic] Univ Laval, Inst Univ Cardiol & Pneumol Quebec, Ctr Rech, Ste Foy, PQ G1V 4G5, Canada.
   [Sonenberg, Nahum] McGill Univ, Dept Biochem, Montreal, PQ H3A 2T5, Canada.
C3 Laval University; Laval University Hospital; McGill University
RP Picard, F (corresponding author), Univ Laval, Inst Univ Cardiol & Pneumol Quebec, Ctr Rech, Y3106 Pavillon Marguerite dYouville,2725 Chemin, Ste Foy, PQ G1V 4G5, Canada.
EM Frederic.Picard@criucpq.ulaval.ca
RI Sonenberg, Nahum/AFN-8144-2022
FU CIHR [MOP-66967, CCI-85677]
FX We thank Dr. David Kwiatkowski and Dr. Katherine Cianflone for their
   generous help on providing MEFs cell lines, and Louise Boivin for expert
   technical assistance. F. Picard holds a FRSQ Junior 2 Investigator
   Award. This work was supported by operating grants from the CIHR
   (MOP-66967 and CCI-85677).
CR Arafat AM, 2009, J CLIN ENDOCR METAB, V94, P5093, DOI 10.1210/jc.2009-0875
   Baxter RC, 2009, TRENDS ENDOCRIN MET, V20, P499, DOI 10.1016/j.tem.2009.07.002
   Blüher M, 2008, OBESITY FACTS, V1, P176, DOI 10.1159/000145930
   BONEY CM, 1994, ENDOCRINOLOGY, V135, P1863, DOI 10.1210/en.135.5.1863
   Degraff DJ, 2007, J CELL PHYSIOL, V213, P261, DOI 10.1002/jcp.21123
   DeMambro VE, 2008, ENDOCRINOLOGY, V149, P2051, DOI 10.1210/en.2007-1068
   Düvel K, 2010, MOL CELL, V39, P171, DOI 10.1016/j.molcel.2010.06.022
   Einstein F.H., 2008, FASEB J
   Elmlinger MW, 2001, MOL CELL ENDOCRINOL, V175, P211, DOI 10.1016/S0303-7207(00)00454-8
   Ernst CW, 1996, J ENDOCRINOL, V149, P417, DOI 10.1677/joe.0.1490417
   Farmer SR, 2006, CELL METAB, V4, P263, DOI 10.1016/j.cmet.2006.07.001
   Firth SM, 2002, ENDOCR REV, V23, P824, DOI 10.1210/er.2001-0033
   Fornoni A, 2006, ENDOCRINOLOGY, V147, P3547, DOI 10.1210/en.2006-0066
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   GOSTELIPETER MA, 1994, ENDOCRINOLOGY, V135, P2558, DOI 10.1210/en.135.6.2558
   Han HJ, 2006, J VET MED SCI, V68, P413, DOI 10.1292/jvms.68.413
   Han VKM, 1996, HORM RES, V45, P160, DOI 10.1159/000184780
   Heald AH, 2006, EXP CLIN ENDOCR DIAB, V114, P371, DOI 10.1055/s-2006-924320
   Hedbacker K, 2010, CELL METAB, V11, P11, DOI 10.1016/j.cmet.2009.11.007
   Hill DJ, 1999, J ENDOCRINOL, V160, P305, DOI 10.1677/joe.0.1600305
   Hoeflich A, 1999, ENDOCRINOLOGY, V140, P5488, DOI 10.1210/en.140.12.5488
   Holzenberger M, 2003, NATURE, V421, P182, DOI 10.1038/nature01298
   Kim SY, 2011, ONCOL REP, V26, P1561, DOI 10.3892/or.2011.1439
   Lafontaine-Lacasse M, 2011, J ENDOCRINOL, V208, P41, DOI 10.1677/JOE-10-0243
   Laplante M, 2009, CURR BIOL, V19, pR1046, DOI 10.1016/j.cub.2009.09.058
   Le Bacquer O, 2007, J CLIN INVEST, V117, P387, DOI 10.1172/JCI29528
   Levitt RJ, 2005, BIOCHEM BIOPH RES CO, V336, P1056, DOI 10.1016/j.bbrc.2005.08.229
   Li Z, 2010, HORM METAB RES, V42, P787, DOI 10.1055/s-0030-1262854
   Lukanova A, 2002, CANCER CAUSE CONTROL, V13, P509, DOI 10.1023/A:1016392129279
   Martin JL, 2007, ENDOCRINOLOGY, V148, P2532, DOI 10.1210/en.2006-1335
   Martin RM, 2006, J CLIN ENDOCR METAB, V91, P3287, DOI 10.1210/jc.2006-0745
   Mattsson A, 2008, GROWTH HORM IGF RES, V18, P506, DOI 10.1016/j.ghir.2008.04.005
   Miard S, 2009, AGING CELL, V8, P449, DOI 10.1111/j.1474-9726.2009.00490.x
   Mireuta M., 2010, GROWTH FACTORS
   Miyako K, 2009, MOL ENDOCRINOL, V23, P169, DOI 10.1210/me.2008-0168
   Nam SY, 1997, INT J OBESITY, V21, P355, DOI 10.1038/sj.ijo.0800412
   Olofsson LE, 2008, J CLIN ENDOCR METAB, V93, P4880, DOI 10.1210/jc.2008-0574
   Peterson TR, 2011, CELL, V146, P408, DOI 10.1016/j.cell.2011.06.034
   Porstmann T, 2008, CELL METAB, V8, P224, DOI 10.1016/j.cmet.2008.07.007
   Ruan WJ, 2010, ACTA DIABETOL, V47, P5, DOI 10.1007/s00592-009-0142-3
   Selman C, 2009, SCIENCE, V326, P140, DOI 10.1126/science.1177221
   Um SH, 2004, NATURE, V431, P200, DOI 10.1038/nature02866
   Wang JL, 1998, NATURE, V393, P684, DOI 10.1038/31474
   Wheatcroft SB, 2007, DIABETES, V56, P285, DOI 10.2337/db06-0436
   Wheatcroft SB, 2009, TRENDS ENDOCRIN MET, V20, P153, DOI 10.1016/j.tem.2009.01.002
   Zhang HB, 2003, J CLIN INVEST, V112, P1223, DOI 10.1172/JCI200317222
NR 46
TC 13
Z9 13
U1 0
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD JUL 6
PY 2012
VL 358
IS 1
BP 63
EP 68
DI 10.1016/j.mce.2012.02.022
PG 6
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 950GY
UT WOS:000304638800008
PM 22410287
OA Green Published
DA 2025-06-11
ER

PT J
AU Ando, K
   Fujita, M
AF Ando, Katsuyuki
   Fujita, Megumi
TI Reactive oxygen species and the central nervous system in salt-sensitive
   hypertension: possible relationship with obesity-induced hypertension
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article
DE central nervous system; obesity; rat models of hypertension; reactive
   oxygen species; sodium balance
ID ANGIOTENSIN-ALDOSTERONE SYSTEM; ARTERIAL-PRESSURE ELEVATION; REGIONAL
   BLOOD-FLOW; BODY-MASS INDEX; OXIDATIVE STRESS; METABOLIC SYNDROME;
   MINERALOCORTICOID RECEPTORS; BAROREFLEX IMPAIRMENT; SYMPATHETIC
   ACTIVITY; SODIUM-REABSORPTION
AB 1. There are multiple and complex mechanisms of salt-induced hypertension; however, central sympathoexcitation plays an important role. In addition, the production of reactive oxygen species (ROS) is increased in salt-sensitive hypertensive humans and animals. Thus, we hypothesized that brain ROS overproduction may increase blood pressure (BP) by central sympathostimulation.
   2. Recently, we demonstrated that ROS levels were elevated in the hypothalamus of salt-sensitive hypertensive animals. Moreover, intracerebroventricular anti-oxidants suppressed BP and renal sympathetic nerve activity more in salt-sensitive than nonsalt- sensitive hypertensive rats. Thus, brain ROS overproduction increased BP through central sympathoexcitation in salt-sensitive hypertension.
   3. Salt sensitivity of BP is enhanced in obesity and metabolic syndrome. Interestingly, it is also suggested that, in obesityinduced hypertension models, increases in BP are caused by brain ROS-induced central sympathoexcitation.
   4. Recent studies suggest that increased ROS production in the brain and central sympathoexcitation may share a common pathway that increases BP in both salt-and obesity-induced hypertension.
C1 [Ando, Katsuyuki] Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Bunkyo Ku, Tokyo 1138655, Japan.
C3 University of Tokyo
RP Ando, K (corresponding author), Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM katsua-tky@umin.ac.jp
FU Grants-in-Aid for Scientific Research [21790797, 22590908] Funding
   Source: KAKEN
CR Alvarez GE, 2002, CIRCULATION, V106, P2533, DOI 10.1161/01.CIR.0000041244.79165.25
   ANDO K, 1994, AM J HYPERTENS, V7, P550, DOI 10.1093/ajh/7.6.550
   ANDO K, 1985, JPN CIRC J, V49, P984, DOI 10.1253/jcj.49.984
   BROD J, 1959, CLIN SCI, V18, P269
   CAMPESE VM, 1982, KIDNEY INT, V21, P371, DOI 10.1038/ki.1982.32
   Campese VM, 2005, HYPERTENSION, V46, P533, DOI 10.1161/01.HYP.0000179088.57586.26
   Chen J, 2009, LANCET, V373, P829, DOI 10.1016/S0140-6736(09)60144-6
   Chinen I, 2007, ENDOCRINOLOGY, V148, P160, DOI 10.1210/en.2006-1132
   DARGIE H, 1990, EUR HEART J, V11, P39, DOI 10.1093/eurheartj/11.suppl_A.39
   de Kloet AD, 2010, PHYSIOL BEHAV, V100, P525, DOI 10.1016/j.physbeh.2010.03.018
   De Wardener HE, 2001, PHYSIOL REV, V81, P1599, DOI 10.1152/physrev.2001.81.4.1599
   DIBONA GF, 1985, FED PROC, V44, P2816
   Eaton SB, 1996, J NUTR, V126, P1732, DOI 10.1093/jn/126.6.1732
   Engeli S, 2005, HYPERTENSION, V45, P356, DOI 10.1161/01.HYP.0000154361.47683.d3
   FOLKOW B, 1983, HYPERTENSION, V5, P399, DOI 10.1161/01.HYP.5.4.399
   FORSYTH RP, 1971, SCIENCE, V173, P546, DOI 10.1126/science.173.3996.546
   Franco M, 2008, BLOOD PURIFICAT, V26, P45, DOI 10.1159/000110563
   Fujita M, 2005, HYPERTENSION, V45, P1165, DOI 10.1161/01.HYP.0000165690.85505.37
   Fujita M, 2007, HYPERTENSION, V50, P360, DOI 10.1161/HYPERTENSIONAHA.107.091009
   FUJITA T, 1986, AM J PHYSIOL, V251, pH926, DOI 10.1152/ajpheart.1986.251.5.H926
   FUJITA T, 1992, HYPERTENSION, V20, P466, DOI 10.1161/01.HYP.20.4.466
   FUJITA T, 1980, AM J MED, V69, P334, DOI 10.1016/0002-9343(80)90002-9
   FUJITA T, 1990, HYPERTENSION, V16, P235, DOI 10.1161/01.HYP.16.3.235
   Fujita T, 2010, HYPERTENSION, V55, P813, DOI 10.1161/HYPERTENSIONAHA.109.149062
   Gang LC, 1992, PHARMACOL REV, V44, P81
   GILL JR, 1988, HYPERTENSION, V11, P312, DOI 10.1161/01.HYP.11.4.312
   Grassi G, 2001, HYPERTENSION, V38, P1316, DOI 10.1161/hy1201.096117
   GREEN HD, 1959, PHYSIOL REV, V39, P617, DOI 10.1152/physrev.1959.39.3.617
   Huang BS, 2009, AM J PHYSIOL-REG I, V296, pR994, DOI 10.1152/ajpregu.90903.2008
   JOHNSON MD, 1977, AM J PHYSIOL, V232, pF298, DOI 10.1152/ajprenal.1977.232.4.F298
   Kanbar R, 2007, AM J PHYSIOL-REG I, V292, pR362, DOI 10.1152/ajpregu.00413.2006
   KASSAB S, 1995, HYPERTENSION, V25, P893, DOI 10.1161/01.HYP.25.4.893
   Kawano Y, 2007, HYPERTENS RES, V30, P879, DOI 10.1291/hypres.30.879
   Kido M, 2005, HYPERTENS RES, V28, P1009, DOI 10.1291/hypres.28.1009
   Kido M, 2008, HYPERTENSION, V51, P225, DOI 10.1161/HYPERTENSIONAHA.107.098251
   Kimura Y, 2005, CIRC RES, V96, P252, DOI 10.1161/01.RES.0000152965.75127.9d
   Krum H, 2009, LANCET, V373, P1275, DOI 10.1016/S0140-6736(09)60566-3
   Laursen JB, 1997, CIRCULATION, V95, P588, DOI 10.1161/01.CIR.95.3.588
   LAWTON WJ, 1988, HYPERTENSION, V11, P529, DOI 10.1161/01.HYP.11.6.529
   Lindley TE, 2004, CIRC RES, V94, P402, DOI 10.1161/01.RES.0000112964.40701.93
   Lob HE, 2010, HYPERTENSION, V55, P277, DOI 10.1161/HYPERTENSIONAHA.109.142646
   Masuo K, 2000, HYPERTENS RES, V23, P303, DOI 10.1291/hypres.23.303
   Matsui H, 2006, HYPERTENSION, V48, P225, DOI 10.1161/01.HYP.0000232617.48372.cb
   MORGAN DA, 1995, HYPERTENSION, V25, P834, DOI 10.1161/01.HYP.25.4.834
   Nagae A, 2009, CIRCULATION, V119, P978, DOI 10.1161/CIRCULATIONAHA.108.824730
   NAKAZONO K, 1991, P NATL ACAD SCI USA, V88, P10045, DOI 10.1073/pnas.88.22.10045
   Ogihara T, 2002, HYPERTENSION, V40, P83, DOI 10.1161/01.HYP.0000022880.45113.C9
   Ohmori K, 2005, ANN EPIDEMIOL, V15, P80, DOI 10.1016/j.annepidem.2004.04.001
   ONO A, 1994, HYPERTENSION, V24, P83, DOI 10.1161/01.HYP.24.1.83
   Ono A, 1997, HYPERTENSION, V29, P808, DOI 10.1161/01.HYP.29.3.808
   Rey FE, 2001, CIRC RES, V89, P408, DOI 10.1161/hh1701.096037
   Ritz E, 2009, PEDIATR NEPHROL, V24, P9, DOI 10.1007/s00467-008-0856-4
   Roberts CK, 2006, METABOLISM, V55, P928, DOI 10.1016/j.metabol.2006.02.022
   ROCCHINI AP, 1989, NEW ENGL J MED, V321, P580, DOI 10.1056/NEJM198908313210905
   SATO Y, 1987, HYPERTENSION, V9, P81, DOI 10.1161/01.HYP.9.1.81
   SATO Y, 1991, AM J PHYSIOL, V260, pR941, DOI 10.1152/ajpregu.1991.260.5.R941
   Schneider MP, 2001, HYPERTENSION, V37, P923, DOI 10.1161/01.HYP.37.3.923
   Shokoji T, 2003, HYPERTENSION, V41, P266, DOI 10.1161/01.HYP.0000049621.85474.CF
   Smith AD, 2006, EXP BIOL MED, V231, P282
   Sun CW, 2009, CIRC RES, V105, P1248, DOI 10.1161/CIRCRESAHA.109.208926
   Swenson SJ, 2004, AM J PHYSIOL-REG I, V286, pR764, DOI 10.1152/ajpregu.00492.2003
   Vaziri ND, 2000, HYPERTENSION, V36, P142, DOI 10.1161/01.HYP.36.1.142
   Vincent HK, 2006, INT J OBESITY, V30, P400, DOI 10.1038/sj.ijo.0803177
   Weinstock M, 1996, CLIN SCI, V90, P287, DOI 10.1042/cs0900287
   Xu H, 2002, AM J PHYSIOL-HEART C, V283, pH885, DOI 10.1152/ajpheart.00134.2002
   Yemane H, 2010, EXP PHYSIOL, V95, P51, DOI 10.1113/expphysiol.2008.046334
   Zanzinger J, 2000, PFLUG ARCH EUR J PHY, V439, P489, DOI 10.1007/s004240050968
   Zhao XG, 2001, J HYPERTENS, V19, P89, DOI 10.1097/00004872-200101000-00012
   Zimmerman MC, 2002, CIRC RES, V91, P1038, DOI 10.1161/01.RES.0000043501.47934.FA
NR 69
TC 26
Z9 30
U1 2
U2 14
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1870
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD JAN
PY 2012
VL 39
IS 1
BP 111
EP 116
DI 10.1111/j.1440-1681.2011.05510.x
PG 6
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 868RI
UT WOS:000298541600018
PM 21388436
DA 2025-06-11
ER

PT J
AU Renke, G
   Starling-Soares, B
   Baesso, T
   Petronio, R
   Aguiar, D
   Paes, R
AF Renke, Guilherme
   Starling-Soares, Bernardo
   Baesso, Thomaz
   Petronio, Rayssa
   Aguiar, Danilo
   Paes, Raphaela
TI Effects of Vitamin D on Cardiovascular Risk and Oxidative Stress
SO NUTRIENTS
LA English
DT Review
DE cardiovascular; vitamin D; 25-hydroxyvitamin D [25(OH)D]; 1;
   25-dihydroxycholecalciferol [1; 25(OH)2D]; calcitriol; oxidative stress
ID PARATHYROID-HORMONE LEVELS; SERUM 25-HYDROXYVITAMIN D; 3RD
   NATIONAL-HEALTH; BLOOD-PRESSURE; METABOLIC SYNDROME; D DEFICIENCY;
   INCIDENT HYPERTENSION; D SUPPLEMENTATION; ENDOTHELIAL DYSFUNCTION;
   ARTERIAL STIFFNESS
AB Introduction: Vitamin D has been primarily studied as an important factor influencing bone and calcium metabolism. Metabolites of vitamin D are essential for whole-body calcium homeostasis, maintaining serum calcium levels within a narrow range by regulating this process in the bones and gut. Nevertheless, its deficiency is also related to increased risk of type 2 diabetes mellitus (T2DM), metabolic syndrome (MS), and cardiovascular disease (CVD)-with increased visceral adipose tissue and body mass index (BMI), as well as the frequently associated hypercholesterolemia. It has been reported that vitamin D levels are inversely related to cardiovascular (CV) risk in men and women. However, the effects of vitamin D on distinct outcomes in women and the dose of supplementation needed to improve clinical endpoints have not been established. 25-Hydroxyvitamin D [25(OH)D] reduces systemic inflammatory mediators in CVD and favors the release of anti-inflammatory cytokines from the immune system. In addition, 25(OH)D can be primarily converted into calcitriol (1,25-dihydroxycholecalciferol [1,25(OH)2D]) in the kidneys through the action of the 1-alpha-hydroxylase enzyme. Calcitriol, through the downregulation mechanism of renin expression, renin-angiotensin-aldosterone system (RAAS) activity, and its interaction with the vitamin D receptor, can bring CV benefits. The calcitriol form also lowers parathyroid hormone (PTH) levels by indirectly causing a reduction in aldosterone and mineralocorticoid synthesis. Elevated plasma aldosterone is related to endothelial dysfunction and CVD in hypovitaminosis D status. Conclusion: Vitamin D supplementation may benefit certain risk groups, as it improves metabolic variables, reducing oxidative stress and CV outcomes. More studies are needed to define interventions with vitamin D in men and women.
C1 [Renke, Guilherme] Brazilian Minist Hlth, Natl Inst Cardiol, BR-21040900 Rio De Janeiro, Brazil.
   [Renke, Guilherme; Baesso, Thomaz; Petronio, Rayssa; Aguiar, Danilo; Paes, Raphaela] Nutrindo Ideais Performance & Nutr Res Ctr, BR-22640100 Rio De Janeiro, Brazil.
   [Starling-Soares, Bernardo] Extreme Sports Nutr Inst INEE, BR-31270901 Belo Horizonte, Brazil.
RP Renke, G (corresponding author), Brazilian Minist Hlth, Natl Inst Cardiol, BR-21040900 Rio De Janeiro, Brazil.; Renke, G (corresponding author), Nutrindo Ideais Performance & Nutr Res Ctr, BR-22640100 Rio De Janeiro, Brazil.
EM renke@renke.com.br
RI Renke, Guilherme/JKJ-2777-2023
OI Renke, Guilherme/0000-0002-7940-3667; , Instituto Nutrindo
   Ideais/0009-0007-9143-4697; Starling-Soares,
   Bernardo/0000-0002-0730-7684
CR Akbari M, 2018, HORM METAB RES, V50, P271, DOI 10.1055/s-0044-101355
   Al-Daghri NM, 2012, CARDIOVASC DIABETOL, V11, DOI 10.1186/1475-2840-11-85
   Andrukhova O, 2014, MOL ENDOCRINOL, V28, P53, DOI 10.1210/me.2013-1252
   Bolland MJ, 2010, AM J CLIN NUTR, V91, P82, DOI 10.3945/ajcn.2009.28424
   Borba V.Z.C., 2013, ENDOCRINOLOGIA 150 N, P1050
   Bouillon R, 2022, NAT REV ENDOCRINOL, V18, P96, DOI 10.1038/s41574-021-00593-z
   Bouillon R, 2019, ENDOCR REV, V40, P1109, DOI 10.1210/er.2018-00126
   Braam LAJLM, 2004, THROMB HAEMOSTASIS, V91, P373, DOI 10.1160/TH03-07-0423
   Brewer LC, 2011, CURR DRUG TARGETS, V12, P54
   Brunaud L, 2009, SURGERY, V146, P1035, DOI 10.1016/j.surg.2009.09.041
   Burgaz A, 2011, J HYPERTENS, V29, P636, DOI 10.1097/HJH.0b013e32834320f9
   Cardus A, 2009, ATHEROSCLEROSIS, V204, P85, DOI 10.1016/j.atherosclerosis.2008.08.020
   Carey RM, 2018, ANN INTERN MED, V168, P351, DOI 10.7326/M17-3203
   Chiu KC, 2004, AM J CLIN NUTR, V79, P820
   Codoñer-Franch P, 2012, J PEDIATR-US, V161, P848, DOI 10.1016/j.jpeds.2012.04.046
   Cojic M, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.610893
   de Sire A, 2022, NUTRIENTS, V14, DOI 10.3390/nu14081586
   DeLuca HF, 2004, AM J CLIN NUTR, V80, p1689S, DOI 10.1093/ajcn/80.6.1689S
   Dong JH, 2012, EUR HEART J, V33, P2980, DOI 10.1093/eurheartj/ehr459
   Dusso AS, 2005, AM J PHYSIOL-RENAL, V289, pF8, DOI 10.1152/ajprenal.00336.2004
   Earthman CP, 2012, INT J OBESITY, V36, P387, DOI 10.1038/ijo.2011.119
   Ferrone F, 2019, BONE, V125, P200, DOI 10.1016/j.bone.2019.05.029
   Forman JP, 2008, HYPERTENSION, V52, P828, DOI 10.1161/HYPERTENSIONAHA.108.117630
   Gallelli L, 2021, NUTRIENTS, V13, DOI 10.3390/nu13113932
   Ganji V, 2011, AM J CLIN NUTR, V94, P225, DOI 10.3945/ajcn.111.013516
   Harris RA, 2011, AM J HYPERTENS, V24, P557, DOI 10.1038/ajh.2011.12
   Holick MF, 2005, SOUTH MED J, V98, P1024, DOI 10.1097/01.SMJ.0000140865.32054.DB
   Holick MF, 2008, AM J CLIN NUTR, V87, p1080S
   Holick MF, 2007, NEW ENGL J MED, V357, P266, DOI 10.1056/NEJMra070553
   Holick MF, 2011, J CLIN ENDOCR METAB, V96, P1911, DOI [10.1210/jc.2011-0385, 10.1210/jc.2011-1193]
   Jablonski NG, 2012, PHILOS T R SOC B, V367, P785, DOI 10.1098/rstb.2011.0308
   Jaimungal S, 2011, NUTR RES, V31, P805, DOI 10.1016/j.nutres.2011.09.005
   Jin JM, 2020, Infectious Diseases, V8, P152, DOI [DOI 10.1101/2020.02.23.20026864, 10.3389/fpubh.2020.00152]
   Kimball SM, 2020, EUR J CLIN NUTR, V74, P1514, DOI 10.1038/s41430-020-00706-3
   Krause R, 1998, LANCET, V352, P709, DOI 10.1016/S0140-6736(05)60827-6
   Kunutsor SK, 2013, EUR J EPIDEMIOL, V28, P205, DOI 10.1007/s10654-013-9790-2
   Li YC, 2002, J CLIN INVEST, V110, P229, DOI [10.1172/JCI200215219, 10.1172/JCI0215219]
   Lupton JR, 2016, J CLIN LIPIDOL, V10, P72, DOI 10.1016/j.jacl.2015.09.006
   Mansournia MA, 2018, HORM METAB RES, V50, P429, DOI 10.1055/a-0630-1303
   Margolis KL, 2012, AM J EPIDEMIOL, V175, P22, DOI 10.1093/aje/kwr274
   Martins D, 2007, ARCH INTERN MED, V167, P1159, DOI 10.1001/archinte.167.11.1159
   McGill AT, 2008, NUTR J, V7, DOI 10.1186/1475-2891-7-4
   Mechica JB., 1999, ARQUIVOS BRASILEIROS, V43, P457, DOI DOI 10.1590/S0004-27301999000600012
   Min B, 2013, KOREAN J PHYSIOL PHA, V17, P385, DOI 10.4196/kjpp.2013.17.5.385
   Mithal A, 2009, OSTEOPOROSIS INT, V20, P1807, DOI 10.1007/s00198-009-0954-6
   Molinari C, 2011, CELL PHYSIOL BIOCHEM, V27, P661, DOI 10.1159/000330075
   Moslemi E, 2022, PHARMACOL RES, V186, DOI 10.1016/j.phrs.2022.106484
   MYRUP B, 1992, ARCH INTERN MED, V152, P2265, DOI 10.1001/archinte.152.11.2265
   Nathan DM, 2015, LANCET DIABETES ENDO, V3, P866, DOI 10.1016/S2213-8587(15)00291-0
   Oh J, 2009, CIRCULATION, V120, P687, DOI 10.1161/CIRCULATIONAHA.109.856070
   Oz F, 2013, CORONARY ARTERY DIS, V24, P392, DOI 10.1097/MCA.0b013e328362b2c8
   Pacifico L, 2011, EUR J ENDOCRINOL, V165, P603, DOI 10.1530/EJE-11-0545
   Petersen RA, 2015, BRIT J NUTR, V114, P1647, DOI 10.1017/S0007114515003372
   Pfeifer M, 2001, J CLIN ENDOCR METAB, V86, P1633, DOI 10.1210/jc.86.4.1633
   Pittas AG, 2007, J CLIN ENDOCR METAB, V92, P2017, DOI 10.1210/jc.2007-0298
   Pittas AG, 2020, J CLIN ENDOCR METAB, V105, DOI 10.1210/clinem/dgaa594
   Ponda MP, 2012, CIRCULATION, V126, P270, DOI 10.1161/CIRCULATIONAHA.111.077875
   Quesada-Gomez JM, 2020, J STEROID BIOCHEM, V202, DOI 10.1016/j.jsbmb.2020.105719
   Reis JP, 2007, DIABETES CARE, V30, P1549, DOI 10.2337/dc06-2438
   RESNICK LM, 1986, ANN INTERN MED, V105, P649, DOI 10.7326/0003-4819-105-5-649
   Rostand SG, 1997, HYPERTENSION, V30, P150, DOI 10.1161/01.HYP.30.2.150
   Rubin MR, 2005, J CLIN ENDOCR METAB, V90, P3326, DOI 10.1210/jc.2004-1400
   Schmitt EB, 2018, MATURITAS, V107, P97, DOI 10.1016/j.maturitas.2017.10.011
   Scragg R, 2007, AM J HYPERTENS, V20, P713, DOI 10.1016/j.amjhyper.2007.01.017
   Sepidarkish M, 2019, PHARMACOL RES, V139, P141, DOI 10.1016/j.phrs.2018.11.011
   Shoelson SE, 2007, GASTROENTEROLOGY, V132, P2169, DOI 10.1053/j.gastro.2007.03.059
   Siniscalchi A, 2019, CURR NEUROVASC RES, V16, P178, DOI 10.2174/1567202616666190412152948
   Skaaby T, 2012, CARDIOLOGY, V123, P62, DOI 10.1159/000341277
   Snijder MB, 2007, J INTERN MED, V261, P558, DOI 10.1111/j.1365-2796.2007.01778.x
   Snijder MB, 2005, J CLIN ENDOCR METAB, V90, P4119, DOI 10.1210/jc.2005-0216
   Stricker H, 2012, EUR J VASC ENDOVASC, V44, P307, DOI 10.1016/j.ejvs.2012.06.023
   Syal SK, 2012, J INVASIVE CARDIOL, V24, P385
   Sypniewska G, 2014, AM J HYPERTENS, V27, P114, DOI 10.1093/ajh/hpt174
   Szeto FL, 2012, MOL ENDOCRINOL, V26, P1091, DOI 10.1210/me.2011-1329
   Tarcin O, 2009, J CLIN ENDOCR METAB, V94, P4023, DOI 10.1210/jc.2008-1212
   Targher G, 2006, CLIN ENDOCRINOL, V65, P593, DOI 10.1111/j.1365-2265.2006.02633.x
   Tomaino K, 2015, AM J HYPERTENS, V28, P1017, DOI 10.1093/ajh/hpu264
   Tomaschitz A, 2014, METABOLISM, V63, P20, DOI 10.1016/j.metabol.2013.08.016
   Tomaschitz A, 2012, CARDIOVASC RES, V94, P10, DOI 10.1093/cvr/cvs092
   Valtueña J, 2013, J NUTR SCI VITAMINOL, V59, P161
   van Ballegooijen AJ, 2014, J AM COLL CARDIOL, V63, P1214, DOI 10.1016/j.jacc.2014.01.012
   Vimaleswaran KS, 2013, PLOS MED, V10, DOI 10.1371/journal.pmed.1001383
   Wang L, 2008, HYPERTENSION, V51, P1073, DOI 10.1161/HYPERTENSIONAHA.107.107821
   Warren T, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10082007
   Weng S, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0054625
   Wortsman J, 2000, AM J CLIN NUTR, V72, P690, DOI 10.1093/ajcn/72.3.690
   Yousef S, 2022, NUTRIENTS, V14, DOI 10.3390/nu14091760
   Zhang HQ, 2014, NUTRITION, V30, P1040, DOI 10.1016/j.nut.2014.02.024
   Zhong W., 2013, J STEROID BIOCHEM, V204, P85
NR 89
TC 55
Z9 57
U1 6
U2 51
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2023
VL 15
IS 3
AR 769
DI 10.3390/nu15030769
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 8V6ET
UT WOS:000930722700001
PM 36771474
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Phillips, SA
   Sylvester, FA
   Frisbee, JC
AF Phillips, SA
   Sylvester, FA
   Frisbee, JC
TI Oxidant stress and constrictor reactivity impair cerebral artery
   dilation in obese Zucker rats
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE rat models of metabolic syndrome; microcirculation; cerebral
   circulation; vascular reactivity
ID SPONTANEOUSLY HYPERTENSIVE RATS; SKELETAL-MUSCLE; DIABETES-MELLITUS;
   OXIDATIVE STRESS; BASILAR ARTERY; NITRIC-OXIDE; RISK-FACTORS; DEPENDENT
   DILATATION; RESISTANCE ARTERIES; ALZHEIMERS-DISEASE
AB This study tested the hypothesis that evolution of the metabolic syndrome in obese Zucker rats (OZR) leads to impaired dilator reactivity of cerebral resistance arteries vs. responses determined in lean Zucker rats (LZR). Middle cerebral arteries (MCA) from 17-wk-old male LZR and OZR were isolated and cannulated with glass micropipettes. Vascular reactivity was assessed in response to challenge with ACh, sodium nitroprusside (SNP), reductions and elevations in PO2, 5-HT, and increased intralumenal pressure. Vessels were treated with the free radical scavenger 4-hydroxy-2,2,6,6- tetramethylpiperidine 1-oxyl (tempol) to assess the role of superoxide production in altering reactivity, and passive vascular wall mechanics was assessed in each vessel. Vascular superoxide production was assessed in isolated arteries using fluorescence microscopy. Vessel dilation to ACh and hypoxia was impaired in OZR vs. LZR, although responses to SNP were normal. Vessel constriction to 5-HT, elevated PO2, and elevated intralumenal pressure was enhanced in OZR vs. LZR. Fluorescence microscopy demonstrated an increased superoxide production in arteries of OZR vs. LZR, correctable by incubation with tempol. Although treatment of vessels from OZR with tempol improved dilation to ACh and hypoxia, constrictor responses to 5-HT, elevated PO2, and pressure were not altered by tempol treatment. Indexes of vessel wall mechanics were comparable between groups. These results suggest that vasodilator reactivity of MCA of OZR in response to endothelium-dependent dilator stimuli is impaired vs. LZR and that this may represent a reduced bioavailability of signaling molecules due to oxidant scavenging. However, oxidative stress-independent increases in myogenic tone and constrictor reactivity may contribute to blunted dilator responses of cerebral microvessels.
C1 W Virginia Univ, Sch Med, Ctr Interdisciplinary Res Cardiovasc Sci, Dept Physiol & Pharmacol, Morgantown, WV 26506 USA.
   Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA.
   Grand Valley State Univ, Dept Biomed Sci, Allendale, MI 49401 USA.
C3 West Virginia University; Medical College of Wisconsin; Grand Valley
   State University
RP W Virginia Univ, Sch Med, Ctr Interdisciplinary Res Cardiovasc Sci, Dept Physiol & Pharmacol, POB 9105, Morgantown, WV 26506 USA.
EM jfrisbee@hsc.wvu.edu
OI Frisbee, Jefferson/0000-0003-2751-0599; Phillips,
   Shane/0000-0001-6030-2367
FU NIDDK NIH HHS [R01-DK-64668] Funding Source: Medline
CR ABIRU T, 1990, CAN J PHYSIOL PHARM, V68, P882, DOI 10.1139/y90-134
   *AM HEART ASS, 2004, STAT SUMM PAG
   ANDERSSON D, 1992, J AUTONOM NERV SYST, V37, P215, DOI 10.1016/0165-1838(92)90043-G
   Arvanitakis Z, 2004, ARCH NEUROL-CHICAGO, V61, P661, DOI 10.1001/archneur.61.5.661
   BAUMBACH GL, 1993, HYPERTENSION, V21, P816, DOI 10.1161/01.HYP.21.6.816
   Benov L, 1998, FREE RADICAL BIO MED, V25, P826, DOI 10.1016/S0891-5849(98)00163-4
   Bohlen HG, 2004, AM J PHYSIOL-HEART C, V286, pH492, DOI 10.1152/ajpheart.00818.2003
   BRAY GA, 1977, FED PROC, V36, P148
   BRAY GA, 1971, PHYSIOL REV, V51, P598, DOI 10.1152/physrev.1971.51.3.598
   Cacabelos R, 2003, NEUROL RES, V25, P567, DOI 10.1179/016164103101202002
   CAMERON NE, 1993, DIABETOLOGIA, V36, P299, DOI 10.1007/BF00400231
   Chung SSM, 2003, J AM SOC NEPHROL, V14, pS233, DOI 10.1097/01.ASN.0000077408.15865.06
   Cohen JA, 2003, AUTON NEUROSCI-BASIC, V108, P73, DOI 10.1016/j.autneu.2003.07.001
   Diaz J, 2004, CEREBROVASC DIS, V17, P43, DOI 10.1159/000074794
   Dröge W, 2002, PHYSIOL REV, V82, P47, DOI 10.1152/physrev.00018.2001
   Dumont AS, 2003, NEUROSURGERY, V52, P653, DOI 10.1227/01.NEU.0000048187.74897.7E
   Dunn WR, 1997, HYPERTENSION, V29, P1140, DOI 10.1161/01.HYP.29.5.1140
   Erdös B, 2004, DIABETES, V53, P1352, DOI 10.2337/diabetes.53.5.1352
   Erdös B, 2004, STROKE, V35, P964, DOI 10.1161/01.STR.0000119753.05670.F1
   Frisbee JC, 2001, AM J PHYSIOL-HEART C, V281, pH1304, DOI 10.1152/ajpheart.2001.281.3.H1304
   Frisbee JC, 2004, J APPL PHYSIOL, V97, P764, DOI 10.1152/japplphysiol.01216.2003
   Frisbee JC, 2003, AM J PHYSIOL-HEART C, V285, pH104, DOI 10.1152/ajpheart.00118.2003
   Frisbee JC, 2002, MICROCIRCULATION, V9, P443, DOI 10.1038/sj.mn.7800160
   Frisbee JC, 2002, AM J PHYSIOL-HEART C, V283, pH2160, DOI 10.1152/ajpheart.00379.2002
   Frisbee JC, 2001, AM J PHYSIOL-HEART C, V281, pH1568, DOI 10.1152/ajpheart.2001.281.4.H1568
   Fulton D, 2004, AM J PHYSIOL-HEART C, V287, pH2384, DOI 10.1152/ajpheart.00280.2004
   GORE RW, 1972, AM J PHYSIOL, V222, P82, DOI 10.1152/ajplegacy.1972.222.1.82
   Green DR, 1998, SCIENCE, V281, P1309, DOI 10.1126/science.281.5381.1309
   HAJDU MA, 1994, AM J PHYSIOL, V266, pH1027, DOI 10.1152/ajpheart.1994.266.3.H1027
   Janiak P, 2002, CARDIOVASC RES, V56, P293, DOI 10.1016/S0008-6363(02)00538-2
   Kashiwagi A, 1999, DIABETES RES CLIN PR, V45, P199, DOI 10.1016/S0168-8227(99)00062-5
   KAUSER K, 1991, CIRC RES, V68, P1154, DOI 10.1161/01.RES.68.4.1154
   Laight DW, 1999, EUR J PHARMACOL, V377, P89, DOI 10.1016/S0014-2999(99)00407-0
   Liu YP, 2002, AM J PHYSIOL-HEART C, V283, pH2276, DOI 10.1152/ajpheart.00635.2002
   LOMBARD JH, 1986, CIRC RES, V58, P565, DOI 10.1161/01.RES.58.4.565
   Mankovsky BN, 1996, J DIABETES COMPLICAT, V10, P228, DOI 10.1016/S1056-8727(96)90006-9
   MATHE D, 1995, DIABETES METAB, V21, P106
   MAYHAN WG, 1989, AM J PHYSIOL, V256, pH621, DOI 10.1152/ajpheart.1989.256.3.H621
   MAYHAN WG, 1992, STROKE, V23, P1499, DOI 10.1161/01.STR.23.10.1499
   Mayhan WG, 1998, BRAIN RES, V783, P326, DOI 10.1016/S0006-8993(97)01387-5
   MEININGER GA, 1987, CIRC RES, V60, P861, DOI 10.1161/01.RES.60.6.861
   Miller FJ, 1998, CIRC RES, V82, P1298, DOI 10.1161/01.RES.82.12.1298
   Miranda FJ, 2002, EUR J PHARMACOL, V439, P121, DOI 10.1016/S0014-2999(02)01438-3
   *N AM ASS STUD OB, 2004, STAT SUMM PAG
   Sadowski M, 2004, NEUROCHEM RES, V29, P1257, DOI 10.1023/B:NERE.0000023612.66691.e6
   Schwaninger RM, 2003, LIFE SCI, V73, P3415, DOI 10.1016/j.lfs.2003.06.029
   SJOGREN A, 1988, ACTA PHYSIOL SCAND, V134, P429, DOI 10.1111/j.1748-1716.1988.tb08511.x
   Sonta T, 2004, FREE RADICAL BIO MED, V37, P115, DOI 10.1016/j.freeradbiomed.2004.04.001
   Stepp DW, 2004, AM J PHYSIOL-HEART C, V286, pH964, DOI 10.1152/ajpheart.00836.2003
   Stepp DW, 2002, AM J PHYSIOL-HEART C, V282, pH816, DOI 10.1152/ajpheart.00695.2001
   SUZUKI H, 1995, HYPERTENSION, V25, P1083, DOI 10.1161/01.HYP.25.5.1083
   Tarpey MM, 2001, CIRC RES, V89, P224, DOI 10.1161/hh1501.094365
   Tegos TJ, 2000, ANGIOLOGY, V51, P793, DOI 10.1177/000331970005101001
   Van Buren T, 1998, N-S ARCH PHARMACOL, V358, P663, DOI 10.1007/PL00005309
   Zimmermann PA, 1997, CIRC RES, V81, P996
NR 55
TC 98
Z9 114
U1 0
U2 4
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD FEB
PY 2005
VL 288
IS 2
BP R522
EP R530
DI 10.1152/ajpregu.00655.2004
PG 9
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 885IC
UT WOS:000226149300027
PM 15514104
DA 2025-06-11
ER

PT S
AU Bueno-Antequera, J
   Munguía-Izquierdo, D
AF Bueno-Antequera, Javier
   Munguia-Izquierdo, Diego
BE Xiao, J
TI Exercise and Schizophrenia
SO PHYSICAL EXERCISE FOR HUMAN HEALTH
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
DE Schizophrenia; Psychosis; Physical activity; Obesity; Physical fitness;
   Exercise
ID MAJOR DEPRESSIVE DISORDER; SEVERE MENTAL-ILLNESS; CARDIOVASCULAR
   RISK-FACTORS; BODY-MASS INDEX; PHYSICAL-ACTIVITY; CARDIORESPIRATORY
   FITNESS; BIPOLAR DISORDER; COHORT PROFILE; SEDENTARY BEHAVIOR; EPA
   GUIDANCE
AB Schizophrenia is a psychiatric disorder characterized by distortions of thinking and perception, with no strictly pathognomonic symptoms that can be divided into positive, negative, and cognitive symptom domains. People with schizophrenia have, between others, a reduced life expectancy and cardiorespiratory and muscular fitness and increased risk of cardiovascular disease, metabolic syndrome, obesity, hypertension, and hyperlipidemia compared to the general population. Furthermore, the economic burden of mental disorders including schizophrenia is evident and it is expected to increase to more than double by 2030. Therefore, reducing the growing burden of mental disorders such as schizophrenia should be a health priority. Improved prevention and treatment are two key factors that may reduce the burden of schizophrenia. Pharmacological- and psychotherapy-based interventions have been traditionally considered for treating schizophrenia disorders; however, there is an increasing amount of scientific evidence confirming that physical activity and physical exercise should be highly considered in prevention and treatment of schizophrenia disorders. In this chapter, we aim to summarize and discuss the research progress of physical activity and exercise in prevention and treatment of schizophrenia disorder. Specifically, we summarized and discussed the research progress of the prognostic use of physical activity for incident schizophrenia; the importance of other outcomes typically improved by physical activity/exercise such as obesity and fitness (cardiorespiratory and muscular fitness) for future schizophrenia; the research progress of the evidence of the benefits of exercise in people with schizophrenia disorders differentiating between effects of exercise on varied health outcomes, cognitive functioning, and cardiorespiratory fitness; and finally the clinical practice recommendations.
C1 [Bueno-Antequera, Javier; Munguia-Izquierdo, Diego] Univ Pablo de Olavide, Phys Performance Sports Res Ctr, Dept Sports & Comp Sci, Sect Phys Educ & Sports,Fac Sports Sci, Seville, Spain.
   [Bueno-Antequera, Javier; Munguia-Izquierdo, Diego] Univ Zaragoza, Res Grp Dev Movimiento Humano, Zaragoza, Spain.
   [Munguia-Izquierdo, Diego] Biomed Res Networking Ctr Frailty & Hlth Aging, Madrid, Spain.
C3 Universidad Pablo de Olavide; University of Zaragoza
RP Munguía-Izquierdo, D (corresponding author), Univ Pablo de Olavide, Phys Performance Sports Res Ctr, Dept Sports & Comp Sci, Sect Phys Educ & Sports,Fac Sports Sci, Seville, Spain.; Munguía-Izquierdo, D (corresponding author), Univ Zaragoza, Res Grp Dev Movimiento Humano, Zaragoza, Spain.; Munguía-Izquierdo, D (corresponding author), Biomed Res Networking Ctr Frailty & Hlth Aging, Madrid, Spain.
EM dmunizq@upo.es
RI Munguía-Izquierdo, Diego/H-6452-2013; Bueno-Antequera,
   Javier/H-5515-2015
OI Bueno-Antequera, Javier/0000-0001-8063-3980
FU Universidad Pablo de Olavide, Andalusian Government [CTS-948];
   Universidad Pablo de Olavide, Spain "A2. Ayudas Puente para la
   Concurrencia al Plan Estatal de I+D"; European University of Madrid,
   Catedra Real Madrid, Spain [P2017/RM08]; Biomedical Research Networking
   Centre on Frailty and Healthy Aging (CIBERFES); FEDER funds from the
   European Union [CB16/10/00477]; Spanish Ministry of Education
   [FPU13/05130]; Departamento de Innovacion, Investigacion y Universidad
   del Gobierno de Aragon y el Fondo Europeo de Desarrollo Regional
   Programa Operativo FEDER Aragon 2014-2020 "Construyendo Europa desde
   Aragon" [FPU13/05130]
FX The work was funded by Research Group CTS-948, Universidad Pablo de
   Olavide, Andalusian Government; Universidad Pablo de Olavide, Spain "A2.
   Ayudas Puente para la Concurrencia al Plan Estatal de I+D"; European
   University of Madrid, Catedra Real Madrid, Spain (funding project number
   P2017/RM08); Biomedical Research Networking Centre on Frailty and
   Healthy Aging (CIBERFES); and FEDER funds from the European Union
   (CB16/10/00477). JBA was supported by the Spanish Ministry of Education
   (grant number FPU13/05130) and by the Departamento de Innovacion,
   Investigacion y Universidad del Gobierno de Aragon y el Fondo Europeo de
   Desarrollo Regional Programa Operativo FEDER Aragon 2014-2020
   "Construyendo Europa desde Aragon" (reference number PUI/2018-337). The
   funders had no role in study design; collection, analysis, and
   interpretation of data; writing the report; and the decision to submit
   the report for publication.
CR Silva BAE, 2015, REV BRAS PSIQUIATR, V37, P271, DOI 10.1590/1516-4446-2014-1595
   Artero EG, 2012, J CARDIOPULM REHABIL, V32, P351, DOI 10.1097/HCR.0b013e3182642688
   Barnes J, 2012, APPL PHYSIOL NUTR ME, V37, P540, DOI [10.1139/h2012-024, 10.1139/H2012-024]
   Bitter I, 2017, EUR PSYCHIAT, V45, P97, DOI 10.1016/j.eurpsy.2017.05.022
   Bouza C, 2010, BMC PUBLIC HEALTH, V10, DOI 10.1186/1471-2458-10-745
   Bouza C, 2010, GEN HOSP PSYCHIAT, V32, P156, DOI 10.1016/j.genhosppsych.2009.11.014
   Bueno-Antequera J, 2018, NUTR METAB CARDIOVAS, V28, P900, DOI 10.1016/j.numecd.2018.05.003
   Bueno-Antequera J, 2017, SCHIZOPHR RES, V197, P6
   Bueno-Antequera J, 2018, SCHIZOPHR RES, V195, P142, DOI 10.1016/j.schres.2017.10.012
   Bueno-Antequera J, 2017, PSYCHIAT RES, V255, P146, DOI 10.1016/j.psychres.2017.05.014
   CASPERSEN CJ, 1985, PUBLIC HEALTH REP, V100
   Chang CK, 2010, BMC PSYCHIATRY, V10, DOI 10.1186/1471-244X-10-77
   Chen LJ, 2018, PSYCHIAT RES, V270, P738, DOI 10.1016/j.psychres.2018.10.044
   Correll CU, 2017, WORLD PSYCHIAT, V16, P163
   Duncan MJ, 2019, PSYCHIAT RES, V271, P311, DOI 10.1016/j.psychres.2018.11.063
   Firth J, 2015, PSYCHOL MED, V45, P1343, DOI 10.1017/S0033291714003110
   Firth J, 2018, SCHIZOPHRENIA BULL, V44, P1293, DOI 10.1093/schbul/sbx149
   Firth J, 2017, BRIT J PHARMACOL, V174, P3161, DOI 10.1111/bph.13772
   Firth J, 2017, SCHIZOPHRENIA BULL, V43, P546, DOI 10.1093/schbul/sbw115
   García-Hermoso A, 2018, SCAND J MED SCI SPOR, V28, P1852, DOI 10.1111/sms.13206
   Garcia-Hermoso A, 2018, ARCH PHYS MED REHAB, V7
   Gardner-Sood P, 2015, PSYCHOL MED, V45, P2619, DOI 10.1017/S0033291715000562
   Gorczynski P, 2018, EXERCISE BASED INTER
   Hallgren M, 2019, PREV MED, V118, P38, DOI 10.1016/j.ypmed.2018.10.009
   Harber MP, 2017, PROG CARDIOVASC DIS, V60, P11, DOI 10.1016/j.pcad.2017.03.001
   Harvey SB, 2018, AM J PSYCHIAT, V175, P28, DOI 10.1176/appi.ajp.2017.16111223
   Heggelund Jorn, 2012, BMC Res Notes, V5, P344, DOI 10.1186/1756-0500-5-344
   Heinimaa M, 2003, INT J METH PSYCH RES, V12, P92, DOI 10.1002/mpr.146
   Henriksson P, 2019, ANN INTERN MED, V170, P230, DOI 10.7326/M18-1861
   Heun R, 2015, EUR PSYCHIAT, V30, P357, DOI 10.1016/j.eurpsy.2015.02.001
   Ikai S, 2014, J ALTERN COMPLEM MED, V20, P823, DOI 10.1089/acm.2014.0205
   JARVELIN MR, 1993, BRIT J OBSTET GYNAEC, V100, P310, DOI 10.1111/j.1471-0528.1993.tb12971.x
   Jobst A, 2016, EUR PSYCHIAT, V33, P18, DOI 10.1016/j.eurpsy.2015.12.003
   Kanamori S, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-29053-x
   Keller-Varady K, 2018, SCHIZOPHR RES, V192, P64, DOI 10.1016/j.schres.2017.06.008
   Kim HJ, 2014, PSYCHIAT RES, V220, P792, DOI 10.1016/j.psychres.2014.09.020
   Kimhy D, 2015, SCHIZOPHRENIA BULL, V41, P859, DOI 10.1093/schbul/sbv022
   Koivukangas J, 2010, SCHIZOPHR RES, V116, P152, DOI 10.1016/j.schres.2009.10.022
   Krokstad S, 2013, INT J EPIDEMIOL, V42, P968, DOI 10.1093/ije/dys095
   Kunutsor SK, 2018, SCHIZOPHR RES, V192, P473, DOI 10.1016/j.schres.2017.04.042
   Kunutsor SK, 2017, SCHIZOPHR RES, V181, P72, DOI 10.1016/j.schres.2016.10.025
   Kuwahara K, 2018, J EPIDEMIOL, V28, P94, DOI 10.2188/jea.JE20170009
   Laursen TM, 2014, ANNU REV CLIN PSYCHO, V10, P425, DOI 10.1146/annurev-clinpsy-032813-153657
   Lawrence D, 2013, BMJ-BRIT MED J, V346, DOI 10.1136/bmj.f2539
   LOHR JB, 1992, SCHIZOPHR RES, V8, P93, DOI 10.1016/0920-9964(92)90024-Y
   Mansikkaniemi K, 2012, ANN MED, V44, P733, DOI 10.3109/07853890.2011.590146
   Martin H, 2017, MENT HEALTH PHYS ACT, V12, P147, DOI 10.1016/j.mhpa.2017.04.003
   McDowell CP, 2018, EXP GERONTOL, V112, P68, DOI 10.1016/j.exger.2018.09.004
   Mitchell AJ, 2015, GEN HOSP PSYCHIAT, V37, P14, DOI 10.1016/j.genhosppsych.2014.11.006
   Najman JM, 2015, INT J EPIDEMIOL, V44, P78, DOI 10.1093/ije/dyu234
   Najman JM, 2005, INT J EPIDEMIOL, V34, P992, DOI 10.1093/ije/dyi119
   Nyberg J, 2018, PSYCHOL MED, V48, P416, DOI [10.1017/S0033291717001763, 10.1017/s0033291717001763]
   Okkenhaug A, 2016, NORD J PSYCHIAT, V70, P111, DOI 10.3109/08039488.2015.1055300
   Olfson M, 2015, JAMA PSYCHIAT, V72, P1172, DOI 10.1001/jamapsychiatry.2015.1737
   Ortega Francisco B, 2018, Prog Prev Med (N Y), V3, pe0013, DOI 10.1097/pp9.0000000000000013
   Ortega FB, 2012, BMJ-BRIT MED J, V345, DOI 10.1136/bmj.e7279
   Partti K, 2015, BRIT J PSYCHIAT, V207, P37, DOI 10.1192/bjp.bp.113.141937
   Rahman MS, 2018, BJPSYCH OPEN, V4, P346, DOI 10.1192/bjo.2018.45
   Raitakari OT, 2008, INT J EPIDEMIOL, V37, P1220, DOI 10.1093/ije/dym225
   Rosenbaum S, 2016, LANCET PSYCHIAT, V3, pE1, DOI 10.1016/S2215-0366(15)00496-4
   Ross R, 2016, CIRCULATION, V134, pE653, DOI 10.1161/CIR.0000000000000461
   Roth GA, 2018, LANCET, V392, P1736, DOI 10.1016/S0140-6736(18)32203-7
   Sanada K, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17101766
   Schmidt SJ, 2015, EUR PSYCHIAT, V30, P388, DOI 10.1016/j.eurpsy.2015.01.013
   Schuch FB, 2018, AM J PSYCHIAT, V175, P631, DOI 10.1176/appi.ajp.2018.17111194
   Shea BJ, 2007, BMC MED RES METHODOL, V7, DOI 10.1186/1471-2288-7-10
   Shea BJ, 2009, J CLIN EPIDEMIOL, V62, P1013, DOI 10.1016/j.jclinepi.2008.10.009
   Sorensen HJ, 2006, ACTA PSYCHIAT SCAND, V114, P49, DOI 10.1111/j.1600-0447.2006.00784.x
   Sormunen E, 2017, NPJ SCHIZOPHR, V3, DOI 10.1038/s41537-016-0007-z
   Soundy A, 2014, INT J THER REHABIL, V21, P410, DOI 10.12968/ijtr.2014.21.9.410
   Stubbs B, 2018, EUR PSYCHIAT, V54, P124, DOI 10.1016/j.eurpsy.2018.07.004
   Stubbs B, 2016, BMC MED, V14, DOI 10.1186/s12916-016-0734-z
   Stubbs B, 2016, J AFFECT DISORDERS, V190, P457, DOI 10.1016/j.jad.2015.10.019
   Suetani S, 2017, J PSYCHIATR RES, V94, P116, DOI 10.1016/j.jpsychires.2017.06.013
   Sugai T, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0166429
   Suvisaari J, 2016, CURR DIABETES REP, V16, DOI 10.1007/s11892-015-0704-4
   Svedenkrans J, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0161314
   Tammelin T, 2007, INT J SPORTS MED, V28, P853, DOI 10.1055/s-2007-964911
   TAYLOR HL, 1955, J APPL PHYSIOL, V8, P73, DOI 10.1152/jappl.1955.8.1.73
   Trautmann S, 2016, EMBO REP, V17, P1245, DOI 10.15252/embr.201642951
   Vancampfort D, 2015, ACTA PSYCHIAT SCAND, V132, P131, DOI 10.1111/acps.12407
   Vancampfort D, 2017, WORLD PSYCHIATRY, V16, P308, DOI 10.1002/wps.20458
   Vancampfort D, 2017, SPORTS MED, V47, P343, DOI 10.1007/s40279-016-0574-1
   Vancampfort D, 2016, DISABIL REHABIL, V38, P2047, DOI [10.3109/09638288.2015.1114037, 10.1080/09638288.2016.1260645]
   Vancampfort D, 2016, WORLD PSYCHIATRY, V15, P166, DOI 10.1002/wps.20309
   Vancampfort D, 2015, SCHIZOPHR RES, V169, P453, DOI 10.1016/j.schres.2015.09.029
   Vancampfort D, 2015, WORLD PSYCHIATRY, V14, P339, DOI 10.1002/wps.20252
   Vanhees L, 2005, EUR J CARDIOV PREV R, V12, P102, DOI 10.1097/00149831-200504000-00004
   Wahlbeck K, 2001, ARCH GEN PSYCHIAT, V58, P48, DOI 10.1001/archpsyc.58.1.48
   Walker ER, 2015, JAMA PSYCHIAT, V72, P334, DOI 10.1001/jamapsychiatry.2014.2502
   Willis BL, 2018, JAMA PSYCHIAT, V75, P911, DOI 10.1001/jamapsychiatry.2018.1467
   World Health Organization, 2018, The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines
   Wykes T, 2015, LANCET PSYCHIAT, V2, P1036, DOI 10.1016/S2215-0366(15)00332-6
   Zammit S, 2007, ACTA PSYCHIAT SCAND, V116, P378, DOI 10.1111/j.1600-0447.2007.01063.x
   Zhang J, 2014, COMPR PSYCHIAT, V55, P1914, DOI 10.1016/j.comppsych.2014.07.018
NR 95
TC 30
Z9 33
U1 4
U2 32
PU SPRINGER-VERLAG SINGAPORE PTE LTD
PI SINGAPORE
PA 152 BEACH ROAD, #21-01/04 GATEWAY EAST, SINGAPORE, 189721, SINGAPORE
SN 0065-2598
EI 2214-8019
BN 978-981-15-1792-1; 978-981-15-1791-4
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2020
VL 1228
BP 317
EP 332
DI 10.1007/978-981-15-1792-1_21
D2 10.1007/978-981-15-1792-1
PG 16
WC Medicine, Research & Experimental; Physiology; Sport Sciences
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Physiology; Sport Sciences
GA BQ5AS
UT WOS:000596720900021
PM 32342467
DA 2025-06-11
ER

PT J
AU Mehta, D
   Voisey, J
   Bruenig, D
   Harvey, W
   Morris, CP
   Lawford, B
   Young, RM
AF Mehta, Divya
   Voisey, Joanne
   Bruenig, Dagmar
   Harvey, Wendy
   Morris, Charles P.
   Lawford, Bruce
   Young, Ross McD
TI Transcriptome analysis reveals novel genes and immune networks
   dysregulated in veterans with PTSD
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE PTSD; Genome-wide; Veterans; Gene expression; Immune; Networks
ID POSTTRAUMATIC-STRESS-DISORDER; METABOLIC SYNDROME; TRAUMA EXPOSURE;
   EXPRESSION; RISK; BRAIN; BLOOD; POLYMORPHISMS; PREVALENCE; DEPRESSION
AB Background: Posttraumatic stress disorder (PTSD) is a serious condition that emerges following trauma exposure and involves long-lasting psychological suffering and health-issues. Uncovering critical genes and molecular networks is essential to understanding the biology of the disorder. We performed a genome-wide scan to identify transcriptome signatures of PTSD.
   Methods: Genome-wide peripheral blood transcriptomic data from 380 service personnel were investigated. This included a discovery sample of 96 Australian Vietnam War veterans and two independent pre and post-deployment replication samples of U.S. Marines (N = 188 and N = 96).
   Results: A total of 60 transcripts were differentially expressed between veterans with and without PTSD, surviving Bonferroni multiple testing correction. Genes within the cytokine-cytokine receptor interaction, Jak-STAT signaling and Toll-like receptor signaling pathways were enriched. For 49% of the genes, gene expression changes were also accompanied by DNA methylation changes. Using replication data from two U.S. Marine cohorts, we observed that of the differentially expressed genes, 71% genes also showed significant gene expression changes between pre and post-deployment. Weighted gene co-expression networks revealed two modules of genes associated with PTSD. The first module (67 genes, p-value = 6e-4) was enriched for genes within the 11p13 locus including BDNF. The second module (266 genes, p-value = 0.01) was enriched for genes in 17q11 including SLC6A4, STATSA and STAT5B.
   Conclusions: We identified novel transcriptomic loci and biological pathways for PTSD in service personnel. Network analysis revealed enrichment of loci harboring key candidate genes in PTSD. These findings highlight the role of transcriptional biomarkers in the molecular etiology of PTSD.
C1 [Mehta, Divya] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Sch Psychol & Counselling, Fac Hlth, 60 Musk Ave, Kelvin Grove, Qld 4059, Australia.
   [Voisey, Joanne; Bruenig, Dagmar; Morris, Charles P.; Lawford, Bruce] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Fac Hlth, Sch Biomed Sci, Kelvin Grove, Qld, Australia.
   [Bruenig, Dagmar; Harvey, Wendy; Lawford, Bruce] Greenslopes Private Hosp, Gallipoli Med Res Fdn, Newdegate St, Greenslopes, Qld 4120, Australia.
   [Young, Ross McD] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Fac Hlth, Kelvin Grove, Qld, Australia.
C3 Queensland University of Technology (QUT); Queensland University of
   Technology (QUT); Gallipoli Medical Research Foundation; Greenslopes
   Private Hospital; Queensland University of Technology (QUT)
RP Mehta, D (corresponding author), Queensland Univ Technol, Inst Hlth & Biomed Innovat, Sch Psychol & Counselling, Fac Hlth, 60 Musk Ave, Kelvin Grove, Qld 4059, Australia.
EM divya.mehta@qut.edu.au
RI Voisey, Joanne/HTL-2238-2023; Young, Ross/AAF-2082-2021; Mehta,
   Divya/ABD-4551-2021
OI Young, Ross/0000-0002-6806-6503; Voisey, Joanne/0000-0001-6645-6164;
   Mehta, Divya/0000-0001-7971-7255; Mehta, Divya
   Deepak/0000-0002-7359-348X; Bruenig, Dagmar/0000-0002-3760-7098
FU Queensland Branch of the Returned and Services League of Australia (RSL
   QLD), Australia; Faculty of Health QUT; IHBI; QUT Vice Chancellors
   Research Fellowship; Gallipoli Medical Research Foundation
FX The authors thank the Gallipoli Medical Research Foundation for their
   support, especially Miriam Dwyer and Dr Sarah McLeay for their project
   management support. The authors would also like to acknowledge Dr
   Madeline Romaniuk for psychological expertise and Dr John Gibson and the
   team at the Keith Payne Unit, and the staff and investigators at
   Greenslopes Private Hospital for their valuable contribution to the
   study. All authors extend their gratitude to the study participants for
   their generous provision of data and time. The PTSD Initiative was
   funded by the Queensland Branch of the Returned and Services League of
   Australia (RSL QLD), Australia. The Gallipoli Medical Research
   Foundation wishes to thank the RSL QLD for their generous donation, and
   Sullivan Nicolaides Pathology and Queensland X-Ray for their in-kind
   support. The authors thank The Faculty of Health QUT, and IHBI for
   financial and administrative support. Divya Mehta was funded via the QUT
   Vice Chancellors Research Fellowship.
CR Alodaib A, 2017, EUR J HUM GENET, V25, P79, DOI 10.1038/ejhg.2016.128
   Breen MS, 2015, MOL PSYCHIATR, V20, P1538, DOI 10.1038/mp.2015.9
   Breen M. S, 2017, NEUROPSYCHOPHARMACOL
   Bruenig D, 2017, GENE, V625, P42, DOI 10.1016/j.gene.2017.04.048
   Bruenig D, 2017, COMPR PSYCHIAT, V74, P125, DOI 10.1016/j.comppsych.2017.01.015
   Bruenig D, 2016, NEURAL PLAST, V2016, DOI 10.1155/2016/6979435
   Chang JT, 2006, BIOINFORMATICS, V22, P2926, DOI 10.1093/bioinformatics/btl483
   Cole SW, 2015, PSYCHONEUROENDOCRINO, V62, P11, DOI 10.1016/j.psyneuen.2015.07.001
   Duncan LE., 2018, MOL PSYCHIATR, DOI [10.1038/mp.2017.77, DOI 10.1038/MP.2017.77]
   Gaiteri C, 2014, GENES BRAIN BEHAV, V13, P13, DOI 10.1111/gbb.12106
   Galecki P, 2011, J AFFECT DISORDERS, V129, P175, DOI 10.1016/j.jad.2010.09.005
   Galecki P, 2010, NEUROSCI LETT, V486, P184, DOI 10.1016/j.neulet.2010.09.048
   Guardado P, 2016, J ANXIETY DISORD, V38, P9, DOI 10.1016/j.janxdis.2015.12.004
   Kim TY, 2017, ACTA PSYCHIAT SCAND, V135, P170, DOI 10.1111/acps.12675
   Klengel T, 2015, NEURON, V86, P1343, DOI 10.1016/j.neuron.2015.05.036
   Koenen KC, 2002, J NERV MENT DIS, V190, P209, DOI 10.1097/00005053-200204000-00001
   Kuan PF, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/s41398-017-0050-1
   Langfelder P, 2008, BMC BIOINFORMATICS, V9, DOI 10.1186/1471-2105-9-559
   Lawford BR, 2013, J AFFECT DISORDERS, V147, P87, DOI 10.1016/j.jad.2012.10.013
   Lee HK, 2004, GENOME RES, V14, P1085, DOI 10.1101/gr.1910904
   Leek JT, 2007, PLOS GENET, V3, P1724, DOI 10.1371/journal.pgen.0030161
   Logue MW, 2015, PSYCHONEUROENDOCRINO, V57, P1, DOI 10.1016/j.psyneuen.2015.03.016
   McLeay SC, 2017, MED J AUSTRALIA, V206, P251, DOI 10.5694/mja16.00935
   Mehta D, 2017, ACTA PSYCHIAT SCAND
   Mehta D, 2013, P NATL ACAD SCI USA, V110, P8302, DOI 10.1073/pnas.1217750110
   Mehta D, 2012, NEUROPHARMACOLOGY, V62, P654, DOI 10.1016/j.neuropharm.2011.03.009
   Mehta D, 2011, ARCH GEN PSYCHIAT, V68, P901, DOI 10.1001/archgenpsychiatry.2011.50
   Miller MW, 2014, MOL PSYCHIATR, V19, P1156, DOI 10.1038/mp.2014.111
   Neylan TC, 2011, BRAIN BEHAV IMMUN, V25, P524, DOI 10.1016/j.bbi.2010.12.001
   Palucka K, 2013, CURR OPIN IMMUNOL, V25, P396, DOI 10.1016/j.coi.2013.05.001
   Piechota M, 2017, BMC NEUROSCI, V18, DOI 10.1186/s12868-017-0352-5
   Preininger M, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003362
   Ramchand R, 2010, J TRAUMA STRESS, V23, P59, DOI 10.1002/jts.20486
   Rasmus A, 2017, ANN AGR ENV MED, V24, P332, DOI 10.26444/aaem/74711
   Robicsek O, 2011, ISR MED ASSOC J, V13, P548
   Rosenbaum S, 2015, METABOLISM, V64, P926, DOI [10.1016/j.metabol.2015.04.009, 10.1016/j.metabol.2015.01.016]
   Sarapas C, 2011, DIS MARKERS, V30, P101, DOI [10.3233/DMA-2011-0764, 10.1155/2011/328054]
   Sartor CE, 2011, PSYCHOL MED, V41, P1497, DOI 10.1017/S0033291710002072
   Sartor CE, 2012, ARCH GEN PSYCHIAT, V69, P293, DOI 10.1001/archgenpsychiatry.2011.1385
   Shi W, 2010, NUCLEIC ACIDS RES, V38, DOI 10.1093/nar/gkq871
   Stein MB, 2002, AM J PSYCHIAT, V159, P1675, DOI 10.1176/appi.ajp.159.10.1675
   Su YA, 2008, INT J BIOL SCI, V4, P223
   Sumner JA, 2017, PSYCHOL MED, V47, P2036, DOI 10.1017/S0033291717000733
   TRUE WR, 1993, ARCH GEN PSYCHIAT, V50, P257, DOI 10.1001/archpsyc.1993.01820160019002
   von Känel R, 2006, PSYCHOSOM MED, V68, P598, DOI 10.1097/01.psy.0000221229.43272.9d
   Wang J, 2013, NUCLEIC ACIDS RES, V41, pW77, DOI 10.1093/nar/gkt439
   Weathers FW, 2014, PSYCHOL INJ LAW, V7, P93, DOI 10.1007/s12207-014-9191-1
   Wingo AP, 2015, BRAIN BEHAV IMMUN, V43, P184, DOI 10.1016/j.bbi.2014.09.016
   Wolf EJ, 2016, PSYCHOL MED, V46, P2215, DOI 10.1017/S0033291716000817
   Yehuda R, 2009, BIOL PSYCHIAT, V66, P708, DOI 10.1016/j.biopsych.2009.02.034
   Zhang L, 2016, WORLD J PSYCHIATR, V6, P1, DOI 10.5498/wjp.v6.i1.1
   Zieker J, 2007, MOL PSYCHIATR, V12, P116, DOI 10.1038/sj.mp.4001905
NR 52
TC 27
Z9 31
U1 1
U2 10
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD NOV
PY 2018
VL 74
BP 133
EP 142
DI 10.1016/j.bbi.2018.08.014
PG 10
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA HF4FB
UT WOS:000454187500015
PM 30189241
DA 2025-06-11
ER

PT J
AU Santana, LF
   Inada, AC
   Santo, BLSD
   Filiú, WFO
   Pott, A
   Alves, FM
   Guimaraes, RDA
   Freitas, KD
   Hiane, PA
AF Santana, Lidiani F.
   Inada, Aline C.
   Spontoni do Espirito Santo, Bruna Larissa
   Filiu, Wander F. O.
   Pott, Arnildo
   Alves, Flavio M.
   Guimaraes, Rita de Cassia A.
   Freitas, Karine de Cassia
   Hiane, Priscila A.
TI Nutraceutical Potential of Carica papaya in Metabolic Syndrome
SO NUTRIENTS
LA English
DT Review
DE blood glucose; food composition; metabolic syndrome; natural products;
   Carica papaya
ID OXIDATIVE STRESS; BENZYL ISOTHIOCYANATE; AQUEOUS EXTRACT;
   PHENOLIC-COMPOUNDS; ACE ACTIVITY; CANCER; LEAF; L.; ETHANOL; LINN
AB Carica papaya L. is a well-known fruit worldwide, and its highest production occurs in tropical and subtropical regions. The pulp contains vitamins A, C, and E, B complex vitamins, such as pantothenic acid and folate, and minerals, such as magnesium and potassium, as well as food fibers. Phenolic compounds, such as benzyl isothiocyanate, glucosinolates, tocopherols (alpha and delta), beta-cryptoxanthin, beta-carotene and carotenoids, are found in the seeds. The oil extracted from the seed principally presents oleic fatty acid followed by palmitic, linoleic and stearic acids, whereas the leaves have high contents of food fibers and polyphenolic compounds, flavonoids, saponins, pro-anthocyanins, tocopherol, and benzyl isothiocyanate. Studies demonstrated that the nutrients present in its composition have beneficial effects on the cardiovascular system, protecting it against cardiovascular illnesses and preventing harm caused by free radicals. It has also been reported that it aids in the treatment of diabetes mellitus and in the reduction of cholesterol levels. Thus, both the pulp and the other parts of the plant (leaves and seeds) present antioxidant, anti-hypertensive, hypoglycemic, and hypolipidemic actions, which, in turn, can contribute to the prevention and treatment of obesity and associated metabolic disorders.
C1 [Santana, Lidiani F.; Inada, Aline C.; Spontoni do Espirito Santo, Bruna Larissa; Guimaraes, Rita de Cassia A.; Freitas, Karine de Cassia; Hiane, Priscila A.] Fed Univ Mato Grosso Sul UFMS, Grad Program Hlth & Dev Cent West Reg Brazil, BR-79079900 Campo Grande, MS, Brazil.
   [Filiu, Wander F. O.] Fed Univ Mato Grosso Sul UFMS, Fac Ciencias Farmaceut Alimentos & Nutr, BR-79079900 Campo Grande, MS, Brazil.
   [Pott, Arnildo; Alves, Flavio M.] Fed Univ Mato Grosso Sul UFMS, Inst Biosci, BR-79079900 Campo Grande, MS, Brazil.
C3 Universidade Federal de Mato Grosso do Sul; Universidade Federal de Mato
   Grosso do Sul; Universidade Federal de Mato Grosso do Sul
RP Freitas, KD (corresponding author), Fed Univ Mato Grosso Sul UFMS, Grad Program Hlth & Dev Cent West Reg Brazil, BR-79079900 Campo Grande, MS, Brazil.
EM kcfreitas@gmail.com
RI Guimarães, Rita de Cássia/JVO-6281-2024; POTT, ARNILDO/I-5759-2012;
   Alves, Flavio/A-7584-2013
OI HIANE, PRISCILA AIKO/0000-0003-1115-4083; Alves,
   Flavio/0000-0001-5634-8266; Inada, Aline/0000-0001-6788-9172
FU graduate program in Health and Development in the Central-West Region of
   Brazil, Federal University of Mato Grosso do Sul-UFMS
FX We thank the graduate program in Health and Development in the
   Central-West Region of Brazil, Federal University of Mato Grosso do
   Sul-UFMS, for support.
CR Adebiyi A, 2005, PHYTOTHER RES, V19, P628, DOI 10.1002/ptr.1706
   Adeneye A. A., 2009, Biology and Medicine, V1, P1
   Adenowo AF, 2014, TROP J PHARM RES, V13, P1877, DOI 10.4314/tjpr.v13i11.15
   Amic D, 2003, CROAT CHEM ACTA, V76, P55
   Anderson EJ, 2009, J CLIN INVEST, V119, P573, DOI 10.1172/JCI37048
   Ando K, 2009, FREE RADICAL BIO MED, V47, P213, DOI 10.1016/j.freeradbiomed.2009.04.030
   Anibijuwon I.I., 2009, ETHNO BOT LEAFTELS, V13, P850
   Aravind G., 2013, J.Med Plants Stud, V1, P7
   Asrih M, 2015, MOL CELL ENDOCRINOL, V418, P55, DOI 10.1016/j.mce.2015.02.018
   Awodele O, 2016, J INTERCULT ETHNOPHA, V5, P27, DOI 10.5455/jice.20160124113528
   Balasuriya N, 2012, FOOD CHEM, V135, P2320, DOI 10.1016/j.foodchem.2012.07.023
   Basu A, 2008, INT J ONCOL, V33, P657, DOI 10.3892/ijo_00000051
   BAYNES JW, 1991, DIABETES, V40, P405, DOI 10.2337/diabetes.40.4.405
   Beckman JS, 1996, AM J PHYSIOL-CELL PH, V271, pC1424
   Bhat GP, 2001, AM J TROP MED HYG, V65, P304, DOI 10.4269/ajtmh.2001.65.304
   Bouanga-Kalou G., 2011, Asian Journal of Agricultural Sciences, V3, P132
   Brasil GA, 2014, PLANTA MED, V80, P1580, DOI 10.1055/s-0034-1383122
   Canini A, 2007, J FOOD COMPOS ANAL, V20, P584, DOI 10.1016/j.jfca.2007.03.009
   Ceriello A, 2000, METABOLISM, V49, P27, DOI 10.1016/S0026-0495(00)80082-7
   Ching LS, 2001, J AGR FOOD CHEM, V49, P3101, DOI 10.1021/jf000891u
   Eno AE, 2000, PHYTOTHER RES, V14, P235, DOI 10.1002/1099-1573(200006)14:4<235::AID-PTR574>3.0.CO;2-G
   Esposito K, 2012, DIABETES CARE, V35, P2402, DOI 10.2337/dc12-0336
   Juárez-Rojop IE, 2012, BMC COMPLEM ALTERN M, V12, DOI 10.1186/1472-6882-12-236
   Ezekwe SA, 2017, J DIABETES METAB, V8, DOI 10.4172/2155-6156.1000740
   Fakeye TO, 2007, TROP J PHARM RES, V6, P671
   Feillet-Coudray C, 2019, LIPIDS, V54, P81, DOI 10.1002/lipd.12128
   Gray AM, 2000, J NUTR, V130, P15
   Grobecker H., 1976, PERIPHERAL CENTRAL C
   GUYTON AC, 1981, FED PROC, V40, P2252
   Hamden K, 2011, J PHYSIOL BIOCHEM, V67, P121, DOI 10.1007/s13105-010-0056-0
   Hasimun P., 2018, INT J PHARM PHYTOCHE, V10, P317
   Johnson O.R., 2015, IOSR J PHARM BIOL SC, V10, P18, DOI [10.9790/3008-10141822, DOI 10.9790/3008-10141822]
   Juárez-Rojop IE, 2014, REV BRAS FARMACOGN, V24, P341, DOI 10.1016/j.bjp.2014.07.012
   Kamer E, 2010, WOUNDS, V22, P27
   Kermanshai R, 2001, PHYTOCHEMISTRY, V57, P427, DOI 10.1016/S0031-9422(01)00077-2
   Krishna K. L., 2008, Natural Product Radiance, V7, P364
   Kumar G, 2011, Elixir Applied Botany, V40, P5534
   Leopoldini M, 2010, J AGR FOOD CHEM, V58, P10768, DOI 10.1021/jf102576j
   Liu SZ, 2013, J ETHNOPHARMACOL, V145, P490, DOI 10.1016/j.jep.2012.11.017
   Luthfunnesa Bari Luthfunnesa Bari, 2006, Pakistan Journal of Biological Sciences, V9, P137, DOI 10.3923/pjbs.2006.137.140
   Franquni JVM, 2013, STEROIDS, V78, P379, DOI 10.1016/j.steroids.2012.12.009
   Maniyar Yasmeen, 2012, J Ayurveda Integr Med, V3, P70, DOI 10.4103/0975-9476.96519
   MARFO EK, 1986, FOOD CHEM, V22, P259, DOI 10.1016/0308-8146(86)90084-1
   Matsui T, 2007, J AGR FOOD CHEM, V55, P99, DOI 10.1021/jf0627672
   Michael M., 2015, WORLD J NUTR HLTH, V3, P47, DOI [10.12691/jnh-3-3-1, DOI 10.12691/JNH-3-3-1]
   Miean KH, 2001, J AGR FOOD CHEM, V49, P3106, DOI 10.1021/jf000892m
   Milind P, 2011, Int Res J Pharm., V2, P6
   MINAMI N, 1993, J HYPERTENS, V11, P523, DOI 10.1097/00004872-199305000-00008
   Miranda-Osorio Pedro H, 2016, Int J Environ Res Public Health, V13, DOI 10.3390/ijerph13050446
   Nayak BS, 2007, INDIAN J EXP BIOL, V45, P739
   Neuza J., 2009, ALIM NUTR ARARAQUARA, V19, P337
   Nwangwa E.K., 2013, Curr. Trends Technol. Sci., V2, P262
   Nwofia G. E., 2012, International Journal of Medicinal and Aromatic Plants, V2, P200
   Oboh Ganiyu, 2014, Journal of Basic and Clinical Physiology and Pharmacology, V25, P21, DOI 10.1515/jbcpp-2013-0002
   Oboh G, 2010, J FOOD NUTR RES-SLOV, V49, P14
   Okewumi T. A., 2012, African Journal of Biotechnology, V11, P8612
   Olagunju J. A., 2009, Biology and Medicine, V1, P11
   Oloyede O. I., 2005, Pakistan Journal of Nutrition, V4, P379
   Omonkhua A. A., 2011, Global Journal of Pure and Applied Sciences, V17, P241
   Osunkwo U., 1994, NIG J PHYSL SCI, V1, P1
   OSUNKWO UA, 1987, MED SCI RES-BIOCHEM, V15, P971
   Otsuki N, 2010, J ETHNOPHARMACOL, V127, P760, DOI 10.1016/j.jep.2009.11.024
   Ottaiano A, 2016, ONCOLOGY-BASEL, V90, P36, DOI 10.1159/000442527
   Owoyele Bamidele V., 2008, Inflammopharmacology, V16, P168, DOI 10.1007/s10787-008-7008-0
   Pacher P, 2008, AM J PATHOL, V173, P2, DOI 10.2353/ajpath.2008.080019
   Palavesam A, 2012, PLOS ONE, V7, DOI [10.1371/journal.pone.0049493, 10.1371/journal.pone.0044390]
   Pandit A, 2013, BRIT J PHARM RES, V3, P648, DOI 10.9734/BJPR/2013/4517
   Rodríguez-López CP, 2019, NUTR HOSP, V36, P43, DOI 10.20960/nh.1889
   Quagliariello V, 2018, NUTRIENTS, V10, DOI 10.3390/nu10091304
   Quagliariello V, 2017, ONCOTARGET, V8, P30606, DOI 10.18632/oncotarget.16725
   Rajkapoor B, 2002, BIOL PHARM BULL, V25, P1645, DOI 10.1248/bpb.25.1645
   Sadeque MZ, 2010, BANGL J PHARMACOL, V5, P48, DOI 10.3329/bjp.v5i1.5305
   Sahib NG, 2012, SCI WORLD J, DOI 10.1100/2012/436039
   Salla S, 2016, LWT-FOOD SCI TECHNOL, V66, P293, DOI 10.1016/j.lwt.2015.09.008
   Samson SL, 2014, ENDOCRIN METAB CLIN, V43, P1, DOI 10.1016/j.ecl.2013.09.009
   Sasidharan S, 2011, NAT PROD RES, V25, P1982, DOI 10.1080/14786419.2010.523703
   Shim YJ, 2003, J ETHNOPHARMACOL, V85, P283, DOI 10.1016/S0378-8741(02)00370-7
   Sule O., 2012, J PHARM BIOMED SCI, V15, P1
   Sunday A., 2014, J PHARMACOGN PHYTOCH, V2, P109
   TANG CS, 1971, PHYTOCHEMISTRY, V10, P117, DOI 10.1016/S0031-9422(00)90258-9
   Tarun Vij Tarun Vij, 2015, Asian Pacific Journal of Tropical Disease, V5, P1
   Teixeira LG, 2012, CIENCIA TECNOL ALIME, V32, P733, DOI 10.1590/S0101-20612012005000099
   Tona L, 1998, J ETHNOPHARMACOL, V61, P57, DOI 10.1016/S0378-8741(98)00015-4
   van Breemen RB, 2008, CANCER LETT, V269, P339, DOI 10.1016/j.canlet.2008.05.016
   Vuong QV, 2013, J HERB MED, V3, P104, DOI 10.1016/j.hermed.2013.04.004
   Wilson RK, 2002, LIFE SCI, V71, P497, DOI 10.1016/S0024-3205(02)01708-3
   World Health Organization (WHO), Obesity and overweight
NR 87
TC 79
Z9 82
U1 3
U2 26
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2019
VL 11
IS 7
AR 1608
DI 10.3390/nu11071608
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA IN7TT
UT WOS:000478885400095
PM 31315213
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Ranhotra, HS
AF Ranhotra, Harmit S.
TI The interplay between retinoic acid receptor-related orphan receptors
   and human diseases
SO JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
LA English
DT Review
DE Orphan nuclear receptors; metabolic syndrome; autoimmunity; inflammation
ID ROR-GAMMA-T; LYMPHOID ORGAN DEVELOPMENT; NUCLEAR HORMONE-RECEPTORS;
   LIVER-X-RECEPTOR; GENE-EXPRESSION; DRUG-METABOLISM; TRANSCRIPTIONAL
   REGULATION; XENOBIOTIC RESPONSE; IMMUNE-RESPONSE; STRESS-RESPONSE
AB The retinoic acid receptor-related orphan receptors (RORs) are an important subfamily of transcriptional regulators of the nuclear receptors superfamily. Their discovery over a decade ago by gene cloning strategy have revealed three major isoforms of these orphan receptors in animals. Generation and analyses of isoform-specific ROR null mice have provided revealed-vital roles for the RORs in animals. The RORs undoubtedly participate in a host of biological functions such a metabolism, immunity, development and differentiation, angiogenesis, circadian clock, xenobiotic/drug metabolism and other tissue physiologies for optimal animal survival. Moreover, intense work in the last one decade also revealed a host of human diseases being modulated by the RORs. A number of diseases, such as cancer, autoimmune diseases, inflammation, osteoporosis, metabolic syndrome etc., strongly support the involvement of RORs in their onset and progression. By involving in such diseases, the RORs are indeed a critical factor for optimal cell function and are being intensely investigated as novel targets for drug interventions in the treatment of various diseases. This review focuses on the current knowledge and status about RORs in a number of human disease conditions.
C1 St Edmunds Coll, Dept Biochem, Orphan Nucl Receptors Lab, Shillong 793003, Meghalaya, India.
RP Ranhotra, HS (corresponding author), St Edmunds Coll, Dept Biochem, Orphan Nucl Receptors Lab, Shillong 793003, Meghalaya, India.
EM harmitran@gmail.com
CR Benoit G, 2006, PHARMACOL REV, V58, P798, DOI 10.1124/pr.58.4.10
   Besnard S, 2001, CIRC RES, V89, P1209, DOI 10.1161/hh2401.101755
   Blumberg B, 1998, GENE DEV, V12, P3195, DOI 10.1101/gad.12.20.3195
   Brown AJ, 1999, ATHEROSCLEROSIS, V142, P1, DOI 10.1016/S0021-9150(98)00196-8
   Brown AJ, 1997, J LIPID RES, V38, P1730
   Chauvet C, 2004, BIOCHEM J, V384, P79, DOI 10.1042/BJ20040709
   Chen YP, 2009, J PHARMACOL EXP THER, V329, P192, DOI 10.1124/jpet.108.148916
   Chopra AR, 2008, SCIENCE, V322, P1395, DOI 10.1126/science.1164847
   Dong C, 2008, NAT REV IMMUNOL, V8, P337, DOI 10.1038/nri2295
   Duguay D, 2009, CHRONOBIOL INT, V26, P1479, DOI 10.3109/07420520903497575
   Dzhagalov I, 2004, J IMMUNOL, V173, P2952, DOI 10.4049/jimmunol.173.5.2952
   Ellingsen T, 2007, J R SOC PROMO HEALTH, V127, P265, DOI 10.1177/1466424007083702
   Faus H, 2006, BIOMED PHARMACOTHER, V60, P520, DOI 10.1016/j.biopha.2006.07.082
   Fujieda H, 2009, J NEUROCHEM, V108, P91, DOI 10.1111/j.1471-4159.2008.05739.x
   Furuzawa-Carballeda J, 2007, AUTOIMMUN REV, V6, P169, DOI 10.1016/j.autrev.2006.10.002
   Gelissen IC, 1996, J BIOL CHEM, V271, P17852, DOI 10.1074/jbc.271.30.17852
   Gold DA, 2007, BRAIN RES, V1140, P19, DOI 10.1016/j.brainres.2005.11.080
   Gong HB, 2007, MOL ENDOCRINOL, V21, P1781, DOI 10.1210/me.2007-0187
   Guo J, 2002, NAT IMMUNOL, V3, P469, DOI 10.1038/ni791
   Harding HP, 1997, MOL ENDOCRINOL, V11, P1737, DOI 10.1210/me.11.11.1737
   Hayhurst GP, 2001, MOL CELL BIOL, V21, P1393, DOI 10.1128/MCB.21.4.1393-1403.2001
   He YW, 2000, IMMUNOL RES, V22, P71, DOI 10.1385/IR:22:2-3:71
   Hermansson J, 2007, SCAND J WORK ENV HEA, V33, P435, DOI 10.5271/sjweh.1165
   Holterhus PM, 2007, DIABETES CARE, V30, P568, DOI 10.2337/dc06-2105
   Honkakoski P, 1998, MOL CELL BIOL, V18, P5652, DOI 10.1128/MCB.18.10.5652
   Hu X, 2000, TRENDS ENDOCRIN MET, V11, P6, DOI 10.1016/S1043-2760(99)00215-5
   Huang ZF, 2007, EXPERT OPIN THER TAR, V11, P737, DOI 10.1517/14728222.11.6.737
   Ito O, 2006, MOL CELL BIOCHEM, V284, P141, DOI 10.1007/s11010-005-9038-x
   Ivanov II, 2007, SEMIN IMMUNOL, V19, P409, DOI 10.1016/j.smim.2007.10.011
   Ivanov II, 2006, CELL, V126, P1121, DOI 10.1016/j.cell.2006.07.035
   Jaradat M, 2006, AM J RESP CRIT CARE, V174, P1299, DOI 10.1164/rccm.200510-1672OC
   Jetten AM, 2001, PROG NUCLEIC ACID RE, V69, P205, DOI 10.1016/S0079-6603(01)69048-2
   Jetten AM, 2002, CELL DEATH DIFFER, V9, P1167, DOI 10.1038/sj.cdd.4401085
   Jetten AM, 2006, AD DEV BIOL, V16, P313, DOI 10.1016/S1574-3349(06)16010-X
   Jetten Anton M, 2009, Nucl Recept Signal, V7, pe003, DOI 10.1621/nrs.07003
   Joo JH, 2007, CANCER RES, V67, P7929, DOI 10.1158/0008-5472.CAN-07-0931
   Kallen J, 2004, J BIOL CHEM, V279, P14033, DOI 10.1074/jbc.M400302200
   Kallen JA, 2002, STRUCTURE, V10, P1697, DOI 10.1016/S0969-2126(02)00912-7
   Kang HS, 2007, PHYSIOL GENOMICS, V31, P281, DOI 10.1152/physiolgenomics.00098.2007
   Kliewer SA, 1998, CELL, V92, P73, DOI 10.1016/S0092-8674(00)80900-9
   Kovtun IV, 2007, NATURE, V447, P447, DOI 10.1038/nature05778
   Lau P, 1999, NUCLEIC ACIDS RES, V27, P411, DOI 10.1093/nar/27.2.411
   Lau P, 2008, J BIOL CHEM, V283, P18411, DOI 10.1074/jbc.M710526200
   Leppkes M, 2009, GASTROENTEROLOGY, V136, P257, DOI 10.1053/j.gastro.2008.10.018
   Lu Y, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0001149
   Makishima M, 2002, SCIENCE, V296, P1313, DOI 10.1126/science.1070477
   Marschall HU, 2006, J LIPID RES, V47, P582, DOI 10.1194/jlr.M500427-JLR200
   Masana MI, 2007, AM J PHYSIOL-REG I, V292, pR2357, DOI 10.1152/ajpregu.00687.2006
   Meyer T, 2000, P NATL ACAD SCI USA, V97, P9197, DOI 10.1073/pnas.150246097
   Miki N, 2004, J BIOL CHEM, V279, P15025, DOI 10.1074/jbc.M313186200
   Miyahara Y, 2008, P NATL ACAD SCI USA, V105, P15505, DOI 10.1073/pnas.0710686105
   Moraitis AN, 2003, J BIOL CHEM, V278, P52511, DOI 10.1074/jbc.M308152200
   Moraitis AN, 1999, MOL ENDOCRINOL, V13, P431, DOI 10.1210/me.13.3.431
   Nagy L, 1999, GENE DEV, V13, P3209, DOI 10.1101/gad.13.24.3209
   Nakagama S, 1998, J COMP NEUROL, V395, P112, DOI 10.1002/(SICI)1096-9861(19980525)395:1<112::AID-CNE8>3.0.CO;2-3
   Nakagawa Y, 2003, DEV NEUROSCI-BASEL, V25, P234, DOI 10.1159/000072271
   Pike ACW, 2000, J STEROID BIOCHEM, V74, P261, DOI 10.1016/S0960-0760(00)00102-3
   Popov VM, 2007, STEROIDS, V72, P221, DOI 10.1016/j.steroids.2006.12.001
   Pouysségur J, 2006, NATURE, V441, P437, DOI 10.1038/nature04871
   Raichur S, 2007, J MOL ENDOCRINOL, V39, P29, DOI 10.1677/jme.1.00010
   Smith DI, 2006, CANCER LETT, V232, P48, DOI 10.1016/j.canlet.2005.06.049
   Sonoda J, 2003, CURR DRUG METAB, V4, P59, DOI 10.2174/1389200033336739
   Srinivas M, 2006, MOL ENDOCRINOL, V20, P1728, DOI 10.1210/me.2005-0505
   Staudinger JL, 2001, P NATL ACAD SCI USA, V98, P3369, DOI 10.1073/pnas.051551698
   Stehlin-Gaon C, 2003, NAT STRUCT BIOL, V10, P820, DOI 10.1038/nsb979
   Steinmetz ACU, 2001, ANNU REV BIOPH BIOM, V30, P329, DOI 10.1146/annurev.biophys.30.1.329
   Stockinger B, 2007, SEMIN IMMUNOL, V19, P353, DOI 10.1016/j.smim.2007.10.008
   Sun ZM, 2000, SCIENCE, V288, P2369, DOI 10.1126/science.288.5475.2369
   Tilley SL, 2007, J IMMUNOL, V178, P3208, DOI 10.4049/jimmunol.178.5.3208
   TRENKNER E, 1986, J NEUROSCI, V6, P1733
   Umemura M, 2007, J IMMUNOL, V178, P3786, DOI 10.4049/jimmunol.178.6.3786
   Uppal H, 2007, HEPATOLOGY, V45, P422, DOI 10.1002/hep.21494
   Urry Z, 2006, CURR ALLERGY ASTHM R, V6, P363, DOI 10.1007/s11882-996-0005-8
   VanCauter E, 1997, ENDOCR REV, V18, P716, DOI 10.1210/er.18.5.716
   Villey I, 1999, EUR J IMMUNOL, V29, P4072, DOI 10.1002/(SICI)1521-4141(199912)29:12<4072::AID-IMMU4072>3.0.CO;2-E
   VuDac N, 1997, J BIOL CHEM, V272, P22401, DOI 10.1074/jbc.272.36.22401
   Wada T, 2008, EXP BIOL MED, V233, P1191, DOI 10.3181/0802-MR-50
   Wada T, 2008, MOL PHARMACOL, V73, P891, DOI 10.1124/mol.107.040741
   Wang YJ, 2010, J BIOL CHEM, V285, P5013, DOI 10.1074/jbc.M109.080614
   Wei P, 2000, NATURE, V407, P920, DOI 10.1038/35038112
   Wolf IM, 2008, J CELL BIOCHEM, V104, P1580, DOI 10.1002/jcb.21755
   Xie W, 2000, NATURE, V406, P435, DOI 10.1038/35019116
   Xie W, 2004, DRUG DISCOV TODAY, V9, P442, DOI 10.1016/S1359-6446(04)03061-2
   Xu W, 2005, BIOCHEM CELL BIOL, V83, P418, DOI 10.1139/O05-057
   Yamamoto T, 2004, BMC MOL BIOL, V5, DOI 10.1186/1471-2199-5-18
   Yamashita S, 2006, CANCER SCI, V97, P64, DOI 10.1111/j.1349-7006.2006.00136.x
   Yang XXO, 2008, J EXP MED, V205, P1063, DOI 10.1084/jem.20071978
   Yang XXO, 2008, IMMUNITY, V28, P29, DOI 10.1016/j.immuni.2007.11.016
   Zhang FP, 2008, NAT IMMUNOL, V9, P1297, DOI 10.1038/ni.1663
   Zhu Y, 2006, ONCOGENE, V25, P2901, DOI 10.1038/sj.onc.1209314
NR 90
TC 10
Z9 12
U1 0
U2 12
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1079-9893
J9 J RECEPT SIG TRANSD
JI J. Recept. Signal Transduct.
PD AUG
PY 2012
VL 32
IS 4
BP 181
EP 189
DI 10.3109/10799893.2012.692120
PG 9
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 975QM
UT WOS:000306526000002
PM 22686165
DA 2025-06-11
ER

PT J
AU Denisenko, YK
   Kytikova, OY
   Novgorodtseva, TP
   Antonyuk, MV
   Gvozdenko, TA
   Kantur, TA
AF Denisenko, Yulia K.
   Kytikova, Oxana Yu
   Novgorodtseva, Tatyana P.
   Antonyuk, Marina V.
   Gvozdenko, Tatyana A.
   Kantur, Tatyana A.
TI Lipid-Induced Mechanisms of Metabolic Syndrome
SO JOURNAL OF OBESITY
LA English
DT Review
ID CHAIN FATTY-ACIDS; INSULIN-RESISTANCE; ADIPOSE-TISSUE;
   CARDIOVASCULAR-DISEASE; RESOLVIN D1; INFLAMMATION; RECEPTORS;
   PLASMALOGENS; OBESITY; OMEGA-3
AB Metabolic syndrome (MetS) has a worldwide tendency to increase and depends on many components, which explains the complexity of diagnosis, approaches to the prevention, and treatment of this pathology. Insulin resistance (IR) is the crucial cause of the MetS pathogenesis, which develops against the background of abdominal obesity. In light of recent evidence, it has been shown that lipids, especially fatty acids (FAs), are important signaling molecules that regulate the signaling pathways of insulin and inflammatory mediators. On the one hand, the lack of n-3 polyunsaturated fatty acids (PUFAs) in the body leads to impaired molecular mechanisms of glucose transport, the formation of unresolved inflammation. On the other hand, excessive formation of free fatty acids (FFAs) underlies the development of oxidative stress and mitochondrial dysfunction in MetS. Understanding the molecular mechanisms of the participation of FAs and their metabolites in the pathogenesis of MetS will contribute to the development of new diagnostic methods and targeted therapy for this disease. The purpose of this review is to highlight recent advances in the study of the effect of fatty acids as modulators of insulin response and inflammatory process in the pathogenesis and treatment for MetS.
C1 [Denisenko, Yulia K.; Kytikova, Oxana Yu; Novgorodtseva, Tatyana P.; Antonyuk, Marina V.; Gvozdenko, Tatyana A.] Inst Med Climatol & Rehabilitat Treatment, Vladivostok Branch, Far Eastern Sci Ctr Physiol & Pathol Respirat, Vladivostok 690105, Russia.
   [Kantur, Tatyana A.] Far Eastern Fed Univ, Vladivostok 690950, Russia.
C3 Far Eastern Federal University
RP Denisenko, YK (corresponding author), Inst Med Climatol & Rehabilitat Treatment, Vladivostok Branch, Far Eastern Sci Ctr Physiol & Pathol Respirat, Vladivostok 690105, Russia.
EM karaman@inbox.ru; kytikova@yandex.ru; curdeal@mail.ru;
   antonyukm@mail.ru; tagvozdenko@mail.ru; kanturovichi@yandex.ru
RI Antonyuk, Marina/I-4862-2016; kytikova, oxana/JCD-9123-2023; Gvozdenko,
   Tatyana/I-6374-2016; Novgorodtseva, Tatyana/E-9441-2016; Denisenko,
   Yulia/L-2292-2015
OI Kytikova, Oxana/0000-0001-5018-0271; Gvozdenko,
   Tatyana/0000-0002-6413-9840; Novgorodtseva, Tatyana/0000-0002-6058-201X;
   Denisenko, Yulia/0000-0003-4130-8899
FU Ministry of Education and Science of the Russian Federation
FX The study was funded by the Ministry of Education and Science of the
   Russian Federation.
CR Albracht-Schulte K, 2018, J NUTR BIOCHEM, V58, P1, DOI 10.1016/j.jnutbio.2018.02.012
   Alicka M, 2018, STEM CELLS INT, V2018, DOI 10.1155/2018/4274361
   Amatruda M, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20092118
   [Anonymous], 2013, INVEST OPHTH VIS SCI
   Aursnes M, 2014, J NAT PROD, V77, P910, DOI 10.1021/np4009865
   Barchuk M, 2020, ARTERIOSCL THROM VAS, V40, P986, DOI 10.1161/ATVBAHA.120.313955
   Barden AE, 2015, AM J CLIN NUTR, V102, P1357, DOI 10.3945/ajcn.115.116384
   Bartoszek A, 2020, PHARMACOL RES, V152, DOI 10.1016/j.phrs.2019.104604
   Bouderba S, 2012, EXP DIABETES RES, DOI 10.1155/2012/430176
   Broniec A, 2017, FREE RADICAL BIO MED, V106, P368, DOI 10.1016/j.freeradbiomed.2017.02.029
   Calder PC, 2020, P NUTR SOC, V79, P404, DOI 10.1017/S0029665120007077
   Calder PC, 2017, BIOCHEM SOC T, V45, P1105, DOI 10.1042/BST20160474
   Cena H, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020334
   Clària J, 2012, J IMMUNOL, V189, P2597, DOI 10.4049/jimmunol.1201272
   Congreve M, 2020, CELL, V181, P81, DOI 10.1016/j.cell.2020.03.003
   Dean JM, 2018, PROTEIN CELL, V9, P196, DOI 10.1007/s13238-017-0423-5
   Denisenko Y. K., 2015, British Journal of Medicine and Medical Research, V8, P975, DOI 10.9734/BJMMR/2015/18536
   Doan E. S. K., 2019, J PERIODONTAL IMPLAN, V49, P105, DOI [10.5051/jpis.2019.49.2.1052-s2.0-85065614941, DOI 10.5051/JPIS.2019.49.2.1052-S2.0-85065614941]
   Messias MCF, 2018, LIPIDS HEALTH DIS, V17, DOI 10.1186/s12944-018-0685-9
   Ghosh A, 2017, J BIOMED SCI, V24, DOI 10.1186/s12929-017-0357-5
   Gilroy DW, 2019, BRIT J PHARMACOL, V176, P1009, DOI 10.1111/bph.14587
   Glass CK, 2012, CELL METAB, V15, P635, DOI 10.1016/j.cmet.2012.04.001
   González-Périz A, 2009, FASEB J, V23, P1946, DOI 10.1096/fj.08-125674
   Grandl G, 2018, SEMIN IMMUNOPATHOL, V40, P215, DOI 10.1007/s00281-017-0666-5
   Guo XH, 2017, NUTRIENTS, V9, DOI 10.3390/nu9050452
   Halter JB, 2014, DIABETES, V63, P2578, DOI 10.2337/db14-0020
   Han MS, 2020, P NATL ACAD SCI USA, V117, P2751, DOI 10.1073/pnas.1920004117
   Harayama T, 2018, NAT REV MOL CELL BIO, V19, P281, DOI 10.1038/nrm.2017.138
   Headland SE, 2015, SEMIN IMMUNOL, V27, P149, DOI 10.1016/j.smim.2015.03.014
   Holloszy JO, 2013, DIABETES, V62, P1036, DOI 10.2337/db12-1107
   Honsho M, 2017, SCI REP-UK, V7, DOI 10.1038/srep43936
   Hu JM, 2018, CRIT REV FOOD SCI, V58, P1243, DOI 10.1080/10408398.2016.1245650
   Huang DG, 2016, J MOL NEUROSCI, V59, P544, DOI 10.1007/s12031-016-0775-y
   Huang SR, 2012, J LIPID RES, V53, P2002, DOI 10.1194/jlr.D029546
   Hwang DH, 2016, EUR J PHARMACOL, V785, P24, DOI 10.1016/j.ejphar.2016.04.024
   Iwase Y., 2015, Pharmacology and Pharmacy, V6, P190, DOI 10.4236/pp.2015.63020
   Jezek P, 2018, MOLECULES, V23, DOI 10.3390/molecules23061483
   Jiang JJ, 2020, BMJ OPEN DIAB RES CA, V8, DOI 10.1136/bmjdrc-2019-000741
   Ju K. O., 2018, OBESITY METABOLISM, V15, P9, DOI [10.14341/OMET95782-s2.0-85064956734, DOI 10.14341/OMET95782-S2.0-85064956734]
   Kim MH, 2013, GASTROENTEROLOGY, V145, P396, DOI 10.1053/j.gastro.2013.04.056
   Kim OK, 2015, ANN NUTR METAB, V67, P218, DOI 10.1159/000440905
   Kim YS, 2015, NUTRIENTS, V7, P2085, DOI 10.3390/nu7042085
   Kimura I, 2020, PHYSIOL REV, V100, P171, DOI 10.1152/physrev.00041.2018
   Kwon Y, 2020, MOL NUTR FOOD RES, V64, DOI 10.1002/mnfr.201900824
   KYTIKOVA O, 2019, MEDICINA, V55, DOI DOI 10.3390/MEDICINA550400872-S2.0-85064192400
   KYTIKOVA O, 2019, MEDICINA, V55, DOI DOI 10.3390/MEDICINA550602842-S2.0-85068496196
   Kytikova O Y, 2019, Adv Gerontol, V32, P948
   Kytikova OY, 2020, PPAR RES, V2020, DOI 10.1155/2020/8906968
   Lalia AZ, 2016, NUTRIENTS, V8, DOI 10.3390/nu8060329
   Lambert C, 2017, NUTRIENTS, V9, DOI 10.3390/nu9060599
   Lark D S, 2012, Int J Obes Suppl, V2, pS31
   Lee JH, 2020, ENVIRON HEALTH PREV, V25, DOI 10.1186/s12199-020-00845-w
   Lee MK, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-59203-z
   Lepretti M, 2018, NUTRIENTS, V10, DOI 10.3390/nu10030350
   Li Y, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8060576
   Ly LD, 2017, EXP MOL MED, V49, DOI 10.1038/emm.2016.157
   Maiers JL, 2019, SEMIN LIVER DIS, V39, P235, DOI 10.1055/s-0039-1681032
   Marcone S, 2016, FRONT IMMUNOL, V7, DOI 10.3389/fimmu.2016.00459
   Martínez-Fernández L, 2015, PROSTAG OTH LIPID M, V121, P24, DOI 10.1016/j.prostaglandins.2015.07.003
   Milligan R, 2002, BMC PUBLIC HEALTH, V2, DOI 10.1186/1471-2458-2-25
   Minihane AM, 2015, BRIT J NUTR, V114, P999, DOI 10.1017/S0007114515002093
   Miyamoto J., 2016, HDB EXPT PHARM, P236
   Miyamoto J, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17040450
   Monnerie S, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-019-56909-7
   Montgomery AA, 2002, BMC HEALTH SERV RES, V2, DOI 10.1186/1472-6963-2-8
   Morshedzadeh N, 2019, DIABETES METAB SYND, V13, P660, DOI 10.1016/j.dsx.2018.11.018
   Neuhofer A, 2013, DIABETES, V62, P1945, DOI 10.2337/db12-0828
   Nilsson PM, 2019, EUR J PREV CARDIOL, V26, P33, DOI 10.1177/2047487319886404
   NOVGORODTSEVA TP, 2011, LIPIDS HLTH DIS, V10, DOI DOI 10.1186/1476-511X-10-822-S2.0-79956048714
   O'Flaherty M, 2002, BMC HEALTH SERV RES, V2, DOI 10.1186/1472-6963-2-16
   Oliveira V, 2015, ENDOCRINOLOGY, V156, P4033, DOI 10.1210/en.2014-1880
   Peebles RS, 2019, PHARMACOL THERAPEUT, V193, P1, DOI 10.1016/j.pharmthera.2018.08.001
   Phinney SD, 2005, AM J CLIN NUTR, V82, P1151, DOI 10.1093/ajcn/82.6.1151
   Pietiläinen KH, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000218
   Prajapati B, 2014, CURR DIABETES REV, V10, P190, DOI 10.2174/1573399810666140515112609
   Pujol JB, 2018, NUTRIENTS, V10, DOI 10.3390/nu10040473
   Radcliffe J. E., 2016, Journal of Nutrition & Intermediary Metabolism, V5, P11, DOI 10.1016/j.jnim.2016.05.002
   Ranasinghe P, 2017, BMC PUBLIC HEALTH, V17, DOI 10.1186/s12889-017-4041-1
   Reddy P, 2019, CLIN CHIM ACTA, V496, P35, DOI 10.1016/j.cca.2019.06.019
   Rieusset J, 2017, ADV EXP MED BIOL, V997, P171, DOI 10.1007/978-981-10-4567-7_13
   Rogero MM, 2018, NUTRIENTS, V10, DOI 10.3390/nu10040432
   Ruysschaert JM, 2015, BBA-BIOMEMBRANES, V1848, P1860, DOI 10.1016/j.bbamem.2015.03.014
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Salas-Burgos A, 2004, BIOPHYS J, V87, P2990, DOI 10.1529/biophysj.104.047886
   Serhan CN, 2018, J CLIN INVEST, V128, P2657, DOI 10.1172/JCI97943
   Serhan CN, 2018, MOL ASPECTS MED, V64, P1, DOI 10.1016/j.mam.2017.08.002
   Shaikh SR, 2015, BBA-BIOMEMBRANES, V1848, P211, DOI 10.1016/j.bbamem.2014.04.020
   Sidletskaya K, 2020, INT J CHRONIC OBSTR, V15, P1481, DOI 10.2147/COPD.S249131
   Sigit FS, 2020, DIABETOL METAB SYNDR, V12, DOI 10.1186/s13098-019-0503-1
   Silva Figueiredo P, 2017, NUTRIENTS, V9, DOI 10.3390/nu9101158
   Sivaprakasam S, 2016, PHARMACOL THERAPEUT, V164, P144, DOI 10.1016/j.pharmthera.2016.04.007
   Su XQ, 2019, LIPIDS HEALTH DIS, V18, DOI 10.1186/s12944-019-1044-1
   Suiter Chase, 2018, Cardiovascular & Hematological Agents in Medicinal Chemistry, V16, P20, DOI 10.2174/1871525716666180528100002
   Sun MM, 2017, J GASTROENTEROL, V52, P1, DOI 10.1007/s00535-016-1242-9
   Surowiec I, 2019, METABOLOMICS, V15, DOI 10.1007/s11306-019-1484-7
   Tortosa-Caparrós E, 2017, CRIT REV FOOD SCI, V57, P3421, DOI 10.1080/10408398.2015.1126549
   Tremblay AJ, 2004, METABOLISM, V53, P310, DOI 10.1016/j.metabol.2003.10.011
   Vazquez-Jimenez J.G., 2019, GAC MEX, V153, P773, DOI [DOI 10.24875/GMM.M18000092, 10.24875/gmm.m18000092]
   Wallner S, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0205706
   Wang HH, 2020, PEDIATR GASTROENTERO, V23, P189
   Wang YM, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-59607-x
   Wassall SR, 2018, BBA-BIOMEMBRANES, V1860, P1985, DOI 10.1016/j.bbamem.2018.04.016
   Weijers RNM, 2016, J DIABETES METAB DIS, V15, DOI 10.1186/s40200-016-0235-9
   Weijers RNM, 2012, CURR DIABETES REV, V8, P390, DOI 10.2174/157339912802083531
   West A, 2020, J PHYS CHEM B, V124, P828, DOI 10.1021/acs.jpcb.9b08850
   Wong SW, 2009, J BIOL CHEM, V284, P27384, DOI 10.1074/jbc.M109.044065
   World Health Organization, 2024, Obesity and Overweight
   Xiang YJ, 2020, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00905
   Yach D, 2006, NAT MED, V12, P62, DOI 10.1038/nm0106-62
   Yonezawa T, 2013, CURR MED CHEM, V20, P3855
   Zhang Q, 2016, J PHARMACOL EXP THER, V357, P337, DOI 10.1124/jpet.116.232033
   Zhenyukh O, 2018, J CELL MOL MED, V22, P4948, DOI 10.1111/jcmm.13759
NR 112
TC 41
Z9 43
U1 2
U2 11
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2090-0708
EI 2090-0716
J9 J OBES
JI J. Obes.
PD AUG 26
PY 2020
VL 2020
AR 5762395
DI 10.1155/2020/5762395
PG 14
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA NQ6OJ
UT WOS:000570990600001
PM 32963827
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Foisy-Sauvé, M
   Ahmarani, L
   Delvin, E
   Sané, AT
   Spahis, S
   Levy, E
AF Foisy-Sauve, Mathilde
   Ahmarani, Lena
   Delvin, Edgard
   Sane, Alain T.
   Spahis, Schohraya
   Levy, Emile
TI Glycomacropeptide Prevents Iron/Ascorbate-Induced Oxidative Stress,
   Inflammation and Insulin Sensitivity with an Impact on Lipoprotein
   Production in Intestinal Caco-2/15 Cells
SO NUTRIENTS
LA English
DT Article
DE glycomacropeptide; oxidative stress; inflammation; insulin sensitivity;
   metabolic syndrome; milk-derived bioactive peptide
ID ACTIVATED PROTEIN-KINASE; DIET-INDUCED OBESITY; KAPPA-B ACTIVATION;
   HIGH-FAT DIET; CASEIN GLYCOMACROPEPTIDE; PHOSPHATIDYLINOSITOL 3-KINASE;
   BOVINE GLYCOMACROPEPTIDE; INCREASED SUSCEPTIBILITY; CHOLESTEROL
   ABSORPTION; SIGNALING PATHWAY
AB Background. Metabolic Syndrome (MetS), a major worldwide concern for the public health system, refers to a cluster of key metabolic components, and represents a risk factor for diabetes and cardiovascular diseases. As oxidative stress (OxS) and inflammation are the major triggers of insulin sensitivity (IS), a cardinal MetS feature, the principal aim of the present work is to determine whether glycomacropeptide (GMP), a milk-derived bioactive peptide, exerts beneficial effects on their expression. Methods. Fully differentiated intestinal Caco-2/15 cells are used to evaluate the preventive action of 2 mg/mL GMP against OxS and inflammation induced by the mixture iron-ascorbate (Fe/Asc) (200 mu M:2 mM). The potency of GMP of decreasing the production of lipoproteins, including chylomicrons (CM), very-low-density lipoproteins (VLDL) and low-density lipoproteins (LDL) is also assessed. Results. The administration of GMP significantly reduces malondialdehyde, a biomarker of lipid peroxidation, and raises superoxide dismutase 2 and glutathione peroxidase via the induction of the nuclear factor erythroid 2-related factor 2, a transcription factor, which orchestrates cellular antioxidant defenses. Similarly, GMP markedly lowers the inflammatory agents tumor necrosis factor-alpha and cyclooxygenase-2 via abrogation of the nuclear transcription factor-kB. Moreover, GMP-treated cells show a down-regulation of Fe/Asc-induced mitogen activated protein kinase pathway, suggesting greater IS. Finally, GMP decreases the production of CM, VLDL, and LDL. Conclusions. Our results highlight the effectiveness of GMP in attenuating OxS, inflammation and lipoprotein biogenesis, as well as improving IS, the key components of MetS. Further investigation is needed to elucidate the mechanisms mediating the preventive action of GMP.
C1 [Foisy-Sauve, Mathilde; Ahmarani, Lena; Delvin, Edgard; Sane, Alain T.; Spahis, Schohraya; Levy, Emile] CHU Ste Justine, Res Ctr, Montreal, PQ H3T 1C5, Canada.
   [Foisy-Sauve, Mathilde; Spahis, Schohraya; Levy, Emile] Univ Montreal, Dept Nutr, Montreal, PQ H3T 1A8, Canada.
C3 Universite de Montreal; Universite de Montreal
RP Levy, E (corresponding author), CHU Ste Justine, Res Ctr, Montreal, PQ H3T 1C5, Canada.; Levy, E (corresponding author), Univ Montreal, Dept Nutr, Montreal, PQ H3T 1A8, Canada.
EM mfois067@uottawa.ca; lena_ahm@yahoo.com; delvine@sympatico.ca;
   sanealaintheo@gmail.com; schohraya.spahis@recherche-ste-justine.qc.ca;
   emile.levy@recherche-ste-justine.qc.ca
OI Levy, Emile/0000-0001-9983-7027; Spahis, Schohraya/0000-0003-4130-4994;
   Delvin, Edgard/0000-0002-3130-7748
FU Dairy Farmers of Canada [E4839]; JA deSeve Research Chair in nutrition;
   FRQS/CIHR Master Scholarship Award
FX This research was funded by the Dairy Farmers of Canada (E4839) and the
   JA deSeve Research Chair in nutrition. M.F.-S. received a FRQS/CIHR
   Master Scholarship Award.
CR Anhê FF, 2015, GUT, V64, P872, DOI 10.1136/gutjnl-2014-307142
   AZUMA N, 1987, J DAIRY RES, V54, P199, DOI 10.1017/S0022029900025346
   Bailey CA, 1996, ADV DRUG DELIVER REV, V22, P85, DOI 10.1016/S0169-409X(96)00416-4
   Ballard O, 2013, PEDIATR CLIN N AM, V60, P49, DOI 10.1016/j.pcl.2012.10.002
   Bautista E, 2016, J TRACE ELEM MED BIO, V34, P62, DOI 10.1016/j.jtemb.2015.11.005
   BEAULIEU JF, 1991, BIOCHEM J, V280, P599, DOI 10.1042/bj2800599
   Bernotti S, 2003, AM J PHYSIOL-GASTR L, V285, pG898, DOI 10.1152/ajpgi.00042.2003
   Blaser H, 2016, TRENDS CELL BIOL, V26, P249, DOI 10.1016/j.tcb.2015.12.002
   Brody EP, 2000, BRIT J NUTR, V84, pS39, DOI 10.1017/S0007114500002233
   Bujko A, 2018, J EXP MED, V215, P441, DOI 10.1084/jem.20170057
   Cani P D, 2016, Int J Obes Suppl, V6, pS28, DOI 10.1038/ijosup.2016.6
   Alfredo SIC, 2018, PHARMACOL RES, V134, P92, DOI 10.1016/j.phrs.2018.06.013
   Chabance B, 1998, BIOCHIMIE, V80, P155, DOI 10.1016/S0300-9084(98)80022-9
   Chen L, 2007, J BIOL CHEM, V282, P5582, DOI 10.1074/jbc.M609273200
   Cheng X, 2015, NUTRIENTS, V7, P3119, DOI 10.3390/nu7053119
   Courtois F, 2003, AM J CLIN NUTR, V77, P744, DOI 10.1093/ajcn/77.3.744
   Cuadrado A, 2010, BIOCHEM J, V429, P403, DOI 10.1042/BJ20100323
   Daddaoua A, 2005, J NUTR, V135, P1164, DOI 10.1093/jn/135.5.1164
   Denis MC, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0053725
   Denis MC, 2015, CLIN SCI, V128, P197, DOI 10.1042/CS20140210
   Drucker DJ, 2007, J CLIN INVEST, V117, P24, DOI 10.1172/JCI30076
   Feeney S, 2017, FOODS, V6, DOI 10.3390/foods6110093
   Fujishiro M, 2003, MOL ENDOCRINOL, V17, P487, DOI 10.1210/me.2002-0131
   Gamble J, 1997, METABOLISM, V46, P1270, DOI 10.1016/S0026-0495(97)90229-8
   Grenier E, 2007, AM J PHYSIOL-GASTR L, V293, pG1178, DOI 10.1152/ajpgi.00295.2007
   Grenier E, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0040992
   Guilloteau P, 2010, REGUL PEPTIDES, V159, P129, DOI 10.1016/j.regpep.2009.09.003
   Guo SD, 2014, J ENDOCRINOL, V220, pE1, DOI 10.1530/JOE-13-0584
   Hahn-Windgassen A, 2005, J BIOL CHEM, V280, P32081, DOI 10.1074/jbc.M502876200
   Hennig P, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19020562
   Hernández-Ledesma B, 2014, INT DAIRY J, V38, P82, DOI 10.1016/j.idairyj.2013.11.004
   Horman S, 2006, J BIOL CHEM, V281, P5335, DOI 10.1074/jbc.M506850200
   Hotamisligil GS, 2016, CSH PERSPECT BIOL, V8, DOI 10.1101/cshperspect.a006072
   Huang CS, 2001, J BIOL CHEM, V276, P40234, DOI 10.1074/jbc.M103684200
   Ilboudo S, 2014, TOXICOL REP, V1, P474, DOI 10.1016/j.toxrep.2014.07.008
   Jaiswal AK, 2004, FREE RADICAL BIO MED, V36, P1199, DOI 10.1016/j.freeradbiomed.2004.02.074
   Jeon SM, 2016, EXP MOL MED, V48, DOI 10.1038/emm.2016.81
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   KAWASAKI Y, 1992, BIOSCI BIOTECH BIOCH, V56, P195, DOI 10.1271/bbb.56.195
   Kennedy SG, 1999, MOL CELL BIOL, V19, P5800
   Kensler TW, 2007, ANNU REV PHARMACOL, V47, P89, DOI 10.1146/annurev.pharmtox.46.120604.141046
   Khor TO, 2008, CANCER PREV RES, V1, P187, DOI 10.1158/1940-6207.CAPR-08-0028
   Khor TO, 2006, CANCER RES, V66, P11580, DOI 10.1158/0008-5472.CAN-06-3562
   Kleme ML, 2018, NUTRIENTS, V10, DOI 10.3390/nu10070836
   Kleme ML, 2016, INT J BIOCHEM CELL B, V74, P84, DOI 10.1016/j.biocel.2016.02.022
   Klotz LO, 2000, BIOCHEM J, V352, P219, DOI 10.1042/0264-6021:3520219
   Konishi H, 1997, FEBS LETT, V410, P493, DOI 10.1016/S0014-5793(97)00541-3
   Kovacic S, 2003, J BIOL CHEM, V278, P39422, DOI 10.1074/jbc.M305371200
   Lauterbach MAR, 2017, PFLUG ARCH EUR J PHY, V469, P385, DOI 10.1007/s00424-017-1955-5
   LEVY E, 1995, FASEB J, V9, P626, DOI 10.1096/fasebj.9.8.7768354
   Levy E, 2007, AM J PHYSIOL-GASTR L, V293, pG1252, DOI 10.1152/ajpgi.00369.2007
   Levy E, 2015, J LIPID RES, V56, P945, DOI 10.1194/jlr.R052415
   Li EWY, 2004, J AGR FOOD CHEM, V52, P2704, DOI 10.1021/jf0355102
   Li GL, 2007, ENDOCRINOLOGY, V148, P3356, DOI 10.1210/en.2006-1441
   Li TG, 2018, FOOD FUNCT, V9, P2524, DOI 10.1039/c7fo01989k
   Li TG, 2017, FOOD FUNCT, V8, P2475, DOI 10.1039/c7fo00481h
   Liu GH, 2008, BBA-MOL CELL RES, V1783, P713, DOI 10.1016/j.bbamcr.2008.01.002
   Mackenzie RWA, 2014, DIABETES METAB SYNDR, V7, P55, DOI 10.2147/DMSO.S48260
   Manning BD, 2017, CELL, V169, P381, DOI 10.1016/j.cell.2017.04.001
   Marcil V, 2010, J BIOL CHEM, V285, P40448, DOI 10.1074/jbc.M110.155358
   Uranga RM, 2013, J BIOL CHEM, V288, P19773, DOI 10.1074/jbc.M113.457622
   Uranga RM, 2009, TOXICOL SCI, V111, P331, DOI 10.1093/toxsci/kfp152
   Martindale JL, 2002, J CELL PHYSIOL, V192, P1, DOI 10.1002/jcp.10119
   McGregor RA, 2013, NUTR METAB, V10, DOI 10.1186/1743-7075-10-46
   Meier R, 1998, EMBO J, V17, P7294, DOI 10.1093/emboj/17.24.7294
   Mikkelsen TL, 2005, J AGR FOOD CHEM, V53, P7673, DOI 10.1021/jf050398o
   Moniruzzaman M, 2018, BIOL RES, V51, DOI 10.1186/s40659-018-0168-5
   Morgan MJ, 2011, CELL RES, V21, P103, DOI 10.1038/cr.2010.178
   Nagpal R, 2011, FOOD FUNCT, V2, P18, DOI 10.1039/c0fo00016g
   Ndong M, 2009, NUTR RES, V29, P640, DOI 10.1016/j.nutres.2009.09.007
   O'Riordan N, 2014, GLYCOBIOLOGY, V24, P220, DOI 10.1093/glycob/cwt162
   Oeckinghaus A, 2011, NAT IMMUNOL, V12, P695, DOI 10.1038/ni.2065
   Otani H, 1996, BIOSCI BIOTECH BIOCH, V60, P1017, DOI 10.1271/bbb.60.1017
   Ozes ON, 1999, NATURE, V401, P82
   Precourt LP, 2009, INT J BIOCHEM CELL B, V41, P1628, DOI 10.1016/j.biocel.2009.02.013
   Qin SF, 2003, BIOCHEMISTRY-US, V42, P2995, DOI 10.1021/bi0205911
   Ravid Z, 2008, AM J PHYSIOL-GASTR L, V295, pG873, DOI 10.1152/ajpgi.90376.2008
   Requena P, 2008, BRIT J PHARMACOL, V154, P825, DOI 10.1038/bjp.2008.138
   Ricci-Cabello I, 2012, NUTR REV, V70, P241, DOI 10.1111/j.1753-4887.2011.00448.x
   Royle PJ, 2008, BRIT J NUTR, V100, P88, DOI 10.1017/S0007114507883000
   RUSHMORE TH, 1991, J BIOL CHEM, V266, P11632
   Samuel VT, 2012, CELL, V148, P852, DOI 10.1016/j.cell.2012.02.017
   Sané A, 2019, J LIPID RES, V60, P1755, DOI 10.1194/jlr.RA119000119
   Sané AT, 2006, J LIPID RES, V47, P2112, DOI 10.1194/jlr.M600174-JLR200
   Sané AT, 2017, ARTERIOSCL THROM VAS, V37, P2243, DOI 10.1161/ATVBAHA.117.310121
   Schauer PR, 2017, NEW ENGL J MED, V376, P641, DOI 10.1056/NEJMoa1600869
   Shah P, 2006, BIOTECHNOL PROGR, V22, P186, DOI 10.1021/bp050208u
   Sharma RS, 2018, CELL MOL GASTROENTER, V5, P367, DOI 10.1016/j.jcmgh.2017.11.016
   Shin S, 2009, EUR J PHARMACOL, V620, P138, DOI 10.1016/j.ejphar.2009.08.022
   Sonoda Y, 1999, J BIOL CHEM, V274, P10566, DOI 10.1074/jbc.274.15.10566
   STROMQVIST M, 1995, J PEDIATR GASTR NUTR, V21, P288, DOI 10.1097/00005176-199510000-00006
   Taha R, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011817
   Thimmulappa RK, 2007, ANTIOXID REDOX SIGN, V9, P1963, DOI 10.1089/ars.2007.1745
   Towler MC, 2007, CIRC RES, V100, P328, DOI 10.1161/01.RES.0000256090.42690.05
   Tsikas D, 2017, ANAL BIOCHEM, V524, P13, DOI 10.1016/j.ab.2016.10.021
   Uranga RM, 2007, J NEUROSCI RES, V85, P2924, DOI 10.1002/jnr.21406
   Valassi E, 2008, NUTR METAB CARDIOVAS, V18, P158, DOI 10.1016/j.numecd.2007.06.004
   Vargas-Bello-Pérez E, 2019, J DAIRY RES, V86, P136, DOI 10.1017/S0022029919000384
   Vasileva LV, 2020, PHARMACOL RES, V156, DOI 10.1016/j.phrs.2020.104760
   Wang XW, 2012, J CELL PHYSIOL, V227, P1168, DOI 10.1002/jcp.22839
   Wang XT, 2000, J BIOL CHEM, V275, P14624, DOI 10.1074/jbc.275.19.14624
   Wang Y, 2018, MED SCI MONITOR, V24, DOI 10.12659/MSM.909910
   Wardyn JD, 2015, BIOCHEM SOC T, V43, P621, DOI 10.1042/BST20150014
   Watson A, 2016, CELL SIGNAL, V28, P412, DOI 10.1016/j.cellsig.2016.01.014
   White MF, 2002, AM J PHYSIOL-ENDOC M, V283, pE413, DOI 10.1152/ajpendo.00514.2001
   WITTERS LA, 1992, J BIOL CHEM, V267, P2864
   Xavier GD, 2000, P NATL ACAD SCI USA, V97, P4023, DOI 10.1073/pnas.97.8.4023
   Xu SP, 2013, FOOD CHEM TOXICOL, V56, P1, DOI 10.1016/j.fct.2013.01.027
   Yu MA, 2011, CELL SIGNAL, V23, P883, DOI 10.1016/j.cellsig.2011.01.014
   Yuan QC, 2020, NUTRIENTS, V12, DOI 10.3390/nu12010220
   Zhang XS, 2017, P NATL ACAD SCI USA, V114, pE7832, DOI 10.1073/pnas.1711042114
   Zhou YN, 2005, PEDIATR RES, V58, P1192, DOI 10.1203/01.pdr.0000185133.65966.4e
   Zimecki M, 2007, J EXP THER ONCOL, V6, P89
NR 113
TC 17
Z9 17
U1 2
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2020
VL 12
IS 4
AR 1175
DI 10.3390/nu12041175
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA LL8VE
UT WOS:000531831300295
PM 32331475
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nunes, CS
   Maes, M
   Roomruangwong, C
   Moraes, JB
   Bonifacio, KL
   Vargas, HO
   Barbosa, DS
   Anderson, G
   de Melo, LGP
   Drozdstoj, S
   Moreira, E
   Carvalho, AF
   Nunes, SOV
AF Nunes, Caroline Sampaio
   Maes, Michael
   Roomruangwong, Chutima
   Moraes, Juliana Brum
   Bonifacio, Kamila Landucci
   Vargas, Heber Odebrecht
   Barbosa, Decio Sabbatini
   Anderson, George
   Piccoli de Melo, Luiz Gustavo
   Drozdstoj, Stoyanov
   Moreira, Estefania
   Carvalho, Andre F.
   Vargas Nunes, Sandra Odebrecht
TI Lowered quality of life in mood disorders is associated with increased
   neuro-oxidative stress and basal thyroid-stimulating hormone levels and
   use of anticonvulsant mood stabilizers
SO JOURNAL OF EVALUATION IN CLINICAL PRACTICE
LA English
DT Article
DE bipolar disorder; child abuse; depressive disorder; quality of life;
   suicide; tobacco use disorder
ID BIPOLAR DISORDER; METABOLIC SYNDROME; CHILDHOOD MALTREATMENT; SYSTEMATIC
   ANALYSIS; MAJOR DEPRESSION; RISK-FACTORS; ANTIOXIDANT; HEALTH;
   DISABILITY; PATHWAYS
AB Rationale, aims Major affective disorders including bipolar disorder (BD) and major depressive disorder (MDD) are associated with impaired health-related quality of life (HRQoL). Oxidative stress and subtle thyroid abnormalities may play a pathophysiological role in both disorders. Thus, the current study was performed to examine whether neuro-oxidative biomarkers and thyroid-stimulating hormone (TSH) levels could predict HRQoL in BD and MDD.
   Methods This cross-sectional study enrolled 68 BD and 37 MDD patients and 66 healthy controls. The World Health Organization (WHO) QoL-BREF scale was used to assess 4 QoL subdomains. Peripheral blood malondialdehyde (MDA), advanced oxidation protein products, paraoxonaxe/CMPAase activity, a composite index of nitro-oxidative stress, and basal TSH were measured.
   Results In the total WHOQoL score, 17.3% of the variance was explained by increased advanced oxidation protein products and TSH levels and lowered CMPAase activity and male gender. Physical HRQoL (14.4%) was associated with increased MDA and TSH levels and lowered CMPAase activity. Social relations HRQoL (17.4%) was predicted by higher nitro-oxidative index and TSH values, while mental and environment HRQoL were independently predicted by CMPAase activity. Finally, 73.0% of the variance in total HRQoL was explained by severity of depressive symptoms, use of anticonvulsants, lower income, early lifetime emotional neglect, MDA levels, the presence of mood disorders, and suicidal ideation.
   Conclusions These data show that lowered HRQoL in major affective disorders could at least in part result from the effects of lipid peroxidation, protein oxidation, lowered antioxidant enzyme activities, and higher levels of TSH.
C1 [Nunes, Caroline Sampaio; Bonifacio, Kamila Landucci; Vargas, Heber Odebrecht; Piccoli de Melo, Luiz Gustavo; Vargas Nunes, Sandra Odebrecht] Univ Estadual Londrina, Hlth Sci Ctr, Dept Psychiat, Londrina, Parana, Brazil.
   [Maes, Michael; Moraes, Juliana Brum; Vargas, Heber Odebrecht; Barbosa, Decio Sabbatini; Piccoli de Melo, Luiz Gustavo; Moreira, Estefania; Vargas Nunes, Sandra Odebrecht] Univ Estadual Londrina, Hlth Sci Ctr, Hlth Sci Graduat Program, Londrina, Parana, Brazil.
   [Maes, Michael; Roomruangwong, Chutima] Chulalongkorn Univ, Dept Psychiat, Fac Med, Bangkok, Thailand.
   [Maes, Michael; Drozdstoj, Stoyanov] Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria.
   [Maes, Michael] Deakin Univ, IMPACT Strateg Res Ctr, Geelong, Vic, Australia.
   [Vargas, Heber Odebrecht] Univ Estadual Londrina, Univ Hosp, Ctr Approach & Treatment Smokers, Londrina, Parana, Brazil.
   [Anderson, George] Clin Res Ctr Scotland & London, London, England.
   [Carvalho, Andre F.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Carvalho, Andre F.] Ctr Addict & Mental Hlth, Toronto, ON, Canada.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   Chulalongkorn University; Medical University Plovdiv; Deakin University;
   Universidade Estadual de Londrina; University of Toronto; University of
   Toronto; Centre for Addiction & Mental Health - Canada
RP Maes, M (corresponding author), Chulalongkorn Univ, Dept Psychiat, Fac Med, Bangkok, Thailand.
EM dr.michaelmaes@hotmail.com
RI de Melo, Luiz Gustavo Piccoli/C-2271-2018; Barbosa, Décio/AAE-6351-2019;
   Brum Moraes, Juliana/AAC-9950-2022; Maes, Michael/B-8546-2011; Carvalho,
   Andre/AEZ-4001-2022; Roomruangwong, Chutima/L-1317-2019; Moreira,
   Estefania/AAC-5959-2019; Anderson, George/AEO-3626-2022
OI Anderson, George/0000-0001-7243-0817; Brum Moraes,
   Juliana/0000-0002-3380-5900; Maes, Michael/0000-0002-2012-871X; Moreira,
   Estefania/0000-0001-8362-9557; Melo, Luiz Gustavo Piccoli
   de/0000-0002-1078-8044
FU Ministry for Science and Technology of Brazil (CNPq) [465928/2014-5,
   470344/2013-0]; Health Sciences Postgraduate Program at Londrina State
   University, Parana, Brazil (UEL)
FX Ministry for Science and Technology of Brazil (CNPq), Grant/Award
   Numbers: 465928/2014-5 and 470344/2013-0; Health Sciences Postgraduate
   Program at Londrina State University, Parana, Brazil (UEL)
CR Agnew-Blais J, 2016, LANCET PSYCHIAT, V3, P342, DOI 10.1016/S2215-0366(15)00544-1
   Ali R, 2002, ADDICTION, V97, P1183
   American Psychiatric Association, DIAGN STAT MAN MENT, V2013, P571
   Avila CC, 2010, BIPOLAR DISORD, V12, P473, DOI 10.1111/j.1399-5618.2010.00833.x
   Balon R, 2006, AM J PSYCHIAT, V163, P1504, DOI 10.1176/appi.ajp.163.9.1504
   Berk M, 2011, NEUROSCI BIOBEHAV R, V35, P804, DOI 10.1016/j.neubiorev.2010.10.001
   Bowden CL, 2005, AM J MANAG CARE, V11, pS91
   Brown NC, 2014, PSYCHIAT RES, V218, P61, DOI 10.1016/j.psychres.2014.04.005
   Bunevicius A, 2017, J NEURO-ONCOL, V131, P385, DOI 10.1007/s11060-016-2311-x
   Carvalho AF, 2016, PSYCHOTHER PSYCHOSOM, V85, P270, DOI 10.1159/000447034
   Chakrabarti S, 2011, J THROID RES, V2011, DOI 10.4061/2011/306367
   Cougle JR, 2015, J PSYCHIATR RES, V66-67, P135, DOI 10.1016/j.jpsychires.2015.05.004
   Dean BB, 2004, CURR MED RES OPIN, V20, P139, DOI 10.1185/030079903125002801
   Del-Ben Cristina Marta, 2001, Revista Brasileira de Psiquiatria, V23, P156, DOI 10.1590/S1516-44462001000300008
   Ekman M, 2013, J AFFECT DISORDERS, V150, P790, DOI 10.1016/j.jad.2013.03.003
   Fleck MPA, 2000, REV SAUDE PUBL, V34, P178, DOI 10.1590/S0034-89102000000200012
   Ford ES, 2008, ANN EPIDEMIOL, V18, P165, DOI 10.1016/j.annepidem.2007.10.009
   Fuchs-Tarlovsky V, 2011, NUTR HOSP, V26, P819, DOI [10.3305/nh.2011.26.4.4894, 10.1590/S0212-16112011000400023]
   Gawel Stefan, 2004, Wiad Lek, V57, P453
   Gomes C, 2018, MOL NEUROBIOL, V55, P2814, DOI 10.1007/s12035-017-0545-z
   Goossens PJJ, 2008, PERSPECT PSYCHIATR C, V44, P275, DOI 10.1111/j.1744-6163.2008.00187.x
   Grassi-Oliveira R, 2006, REV SAUDE PUBL, V40, P249, DOI 10.1590/S0034-89102006000200010
   Gutiérrez-Rojas L, 2008, BIPOLAR DISORD, V10, P625, DOI 10.1111/j.1399-5618.2008.00604.x
   Harvey PD, 2006, J CLIN PSYCHIAT, V67, P14, DOI 10.4088/JCP.1006e13
   Henrique Iara Ferraz Silva, 2004, Rev. Assoc. Med. Bras., V50, P199, DOI 10.1590/S0104-42302004000200039
   HERRMAN H, 1993, QUAL LIFE RES, V2, P153
   IsHak WW, 2015, ACTA PSYCHIAT SCAND, V131, P51, DOI 10.1111/acps.12301
   Jiménez E, 2017, BIPOLAR DISORD, V19, P363, DOI 10.1111/bdi.12514
   Katon WJ, 2010, NEW ENGL J MED, V363, P2611, DOI 10.1056/NEJMoa1003955
   Kim JH, 2012, J GERONTOL NURS, V38, P48, DOI 10.3928/00989134-20121003-01
   Lee YJ, 2012, ANN NUTR METAB, V61, P275, DOI 10.1159/000341494
   Liu TY, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0114851
   Lopez AD, 2006, LANCET, V367, P1747, DOI 10.1016/S0140-6736(06)68770-9
   Machado MO, 2017, J AFFECT DISORDERS, V209, P235, DOI 10.1016/j.jad.2016.11.039
   MACKNESS MI, 1993, BIOCHEM J, V294, P829, DOI 10.1042/bj2940829
   MAERTENS P, 1995, AM J MED GENET, V57, P225, DOI 10.1002/ajmg.1320570222
   MAES M, 1993, PSYCHONEUROENDOCRINO, V18, P607, DOI 10.1016/0306-4530(93)90037-L
   Maes M, 2011, PROG NEURO-PSYCHOPH, V35, P676, DOI 10.1016/j.pnpbp.2010.05.004
   Martín-Subero M, 2014, COMPR PSYCHIAT, V55, P1540, DOI 10.1016/j.comppsych.2014.05.009
   Michalak EE, 2006, QUAL LIFE RES, V15, P25, DOI 10.1007/s11136-005-0376-7
   Michalak Erin E, 2005, Health Qual Life Outcomes, V3, P72, DOI 10.1186/1477-7525-3-72
   Mitra M, 2004, AM J PREV MED, V27, P258, DOI 10.1016/j.amepre.2004.06.002
   Moreira EG, 2019, WORLD J BIOL PSYCHIA, V20, P368, DOI 10.1080/15622975.2017.1322219
   Moreno R.A., 1998, Revista de Psiquiatria Clinica, V25, P262
   Murray CJL, 2012, LANCET, V380, P2197, DOI 10.1016/S0140-6736(12)61729-2
   Naziroglu M, 2013, CELL MOL NEUROBIOL, V33, P589, DOI 10.1007/s10571-013-9936-5
   Nelson J, 2017, BRIT J PSYCHIAT, V210, P96, DOI 10.1192/bjp.bp.115.180752
   Niketic V, 1995, FARMACO, V50, P811
   Ott J, 2011, THYROID, V21, P161, DOI 10.1089/thy.2010.0191
   Ozgocmen S, 2007, MOL CELL BIOCHEM, V295, P45, DOI 10.1007/s11010-006-9270-z
   Pandrc MS, 2017, J MED BIOCHEM, V36, P127, DOI 10.1515/jomb-2017-0007
   de Castro MRP, 2010, J BRAS PNEUMOL, V36, P67, DOI 10.1590/S1806-37132010000100012
   Posner K, 2011, AM J PSYCHIAT, V168, P1266, DOI 10.1176/appi.ajp.2011.10111704
   Roomruangwong C, 2017, J AFFECT DISORDERS, V223, P49, DOI 10.1016/j.jad.2017.07.002
   Roy P, 2008, ANTIEPILEPTIC DRUGS, P103
   RYYNANEN OP, 1993, SCAND J SOC MED, V21, P264, DOI 10.1177/140349489302100406
   Ryynanen OP, 1993, NORD J PSYCHIAT, V47, P67
   Schatzberg A.F., 2007, Manual of clinical psychopharmacology, V6th
   Schmitz N, 2003, AM J PSYCHIAT, V160, P1670, DOI 10.1176/appi.ajp.160.9.1670
   Schulpis KH, 2006, TOXICOLOGY, V217, P228, DOI 10.1016/j.tox.2005.10.004
   Solmi M, 2017, THER CLIN RISK MANAG, V13, P757, DOI 10.2147/TCRM.S117321
   Springer KW, 2007, CHILD ABUSE NEGLECT, V31, P517, DOI 10.1016/j.chiabu.2007.01.003
   Tognini S, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00153
   Vargas HO, 2014, LIFE SCI, V102, P65, DOI 10.1016/j.lfs.2014.02.033
   Vargas HO, 2013, J AFFECT DISORDERS, V150, P923, DOI 10.1016/j.jad.2013.05.016
   Nunes SOV, 2015, J AFFECT DISORDERS, V172, P55, DOI 10.1016/j.jad.2014.09.038
   Vieta E, 2005, HUM PSYCHOPHARM CLIN, V20, P225, DOI 10.1002/hup.689
   Winther KH, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0156925
   Woo JM, 2014, HEALTH QUAL LIFE OUT, V12, DOI 10.1186/s12955-014-0188-y
   Wysokinski A, 2014, NEUROCHEM RES, V39, P1245, DOI 10.1007/s11064-014-1305-3
   Yatham LN, 2013, BIPOLAR DISORD, V15, P1, DOI 10.1111/bdi.12025
   Young AS, 2001, ARCH GEN PSYCHIAT, V58, P55, DOI 10.1001/archpsyc.58.1.55
NR 72
TC 22
Z9 23
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1356-1294
EI 1365-2753
J9 J EVAL CLIN PRACT
JI J. Eval. Clin. Pract.
PD AUG
PY 2018
VL 24
IS 4
BP 869
EP 878
DI 10.1111/jep.12918
PG 10
WC Health Care Sciences & Services; Medical Informatics; Medicine, General
   & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Medical Informatics; General & Internal
   Medicine
GA GO6HQ
UT WOS:000440140900032
PM 29665163
DA 2025-06-11
ER

PT J
AU Holmannova, D
   Borska, L
   Andrys, C
   Borsky, P
   Kremlacek, J
   Hamakova, K
   Rehacek, V
   Malkov, A
   Svadlakova, T
   Palicka, V
   Krejsek, J
   Fiala, Z
AF Holmannova, Drahomira
   Borska, Lenka
   Andrys, Ctirad
   Borsky, Pavel
   Kremlacek, Jan
   Hamakova, Kvetoslava
   Rehacek, Vit
   Malkov, Andrea
   Svadlakova, Tereza
   Palicka, Vladimir
   Krejsek, Jan
   Fiala, Zdenek
TI The Impact of Psoriasis and Metabolic Syndrome on the Systemic
   Inflammation and Oxidative Damage to Nucleic Acids
SO JOURNAL OF IMMUNOLOGY RESEARCH
LA English
DT Article
ID CIRCULATING BETATROPHIN; DNA-DAMAGE; PATHOGENESIS; DISEASE; ANGPTL8;
   OBESITY; STRESS; CALPROTECTIN; EXPRESSION; CELLS
AB Background. Psoriasis is a chronic systemic inflammatory disease associated with a wide range of comorbidities, including metabolic syndrome (MetS). Serum calprotectin, ANGPTL8, and oxidative damage to nucleic acids might be associated with both diseases. The presented study describes the influence of psoriasis and MetS on the serum levels of markers of systemic inflammation (calprotectin and ANGPTL8) and markers of oxidative damage to nucleic acids. The applicability of serum levels of calprotectin and ANGPTL8 for monitoring of the activity of psoriasis (diagnostic markers) is also evaluated. Methods. Clinical examination (PASI score, MetS), enzyme-linked immunosorbent assay (ELISA), and Enzyme Immunoassay (EIA). Serum calprotectin, ANGPTL8, 8-hydroxy-2 '-deoxyguanosine, 8-hydroxyguanosine, and 8-hydroxyguanine. Results and Conclusions. The psoriasis significantly increased the serum level of calprotectin and the serum level of oxidative damage to nucleic acids, however not the serum level of ANGPTL8. The presence of MetS did not significantly affect the serum levels of calprotectin, ANGPTL8, and oxidative damage to nucleic acids in either psoriasis patients or controls. It seems that the serum level of calprotectin (but not the serum level of ANGPTL8) could be used as a biomarker for monitoring the activity of psoriasis.
C1 [Holmannova, Drahomira; Borsky, Pavel; Malkov, Andrea; Svadlakova, Tereza; Fiala, Zdenek] Charles Univ Prague, Fac Med Hradec Kralove, Inst Hyg & Prevent Med, Hradec Kralove, Czech Republic.
   [Borska, Lenka; Borsky, Pavel; Kremlacek, Jan] Charles Univ Prague, Fac Med Hradec Kralove, Inst Pathol Physiol, Hradec Kralove, Czech Republic.
   [Andrys, Ctirad; Svadlakova, Tereza; Krejsek, Jan] Charles Univ Prague, Univ Hosp, Inst Clin Immunol & Allergol, Hradec Kralove, Czech Republic.
   [Andrys, Ctirad; Svadlakova, Tereza; Palicka, Vladimir; Krejsek, Jan] Charles Univ Prague, Fac Med Hradec Kralove, Hradec Kralove, Czech Republic.
   [Hamakova, Kvetoslava] Univ Hosp Hradec Kralove, Clin Dermatol & Venereol, Hradec Kralove, Czech Republic.
   [Rehacek, Vit] Univ Hosp, Transfus Ctr, Hradec Kralove 50003, Czech Republic.
   [Palicka, Vladimir] Charles Univ Prague, Univ Hosp Hradec Kralove, Inst Clin Biochem & Diagnost, Hradec Kralove, Czech Republic.
C3 Charles University Prague; University Hospital Hradec Kralove;
   University Hospital Hradec Kralove; Charles University Prague; Charles
   University Prague; University Hospital Hradec Kralove; University
   Hospital Hradec Kralove; Charles University Prague; University Hospital
   Hradec Kralove; University Hospital Hradec Kralove; Charles University
   Prague; University Hospital Hradec Kralove
RP Borsky, P (corresponding author), Charles Univ Prague, Fac Med Hradec Kralove, Inst Hyg & Prevent Med, Hradec Kralove, Czech Republic.; Borsky, P (corresponding author), Charles Univ Prague, Fac Med Hradec Kralove, Inst Pathol Physiol, Hradec Kralove, Czech Republic.
EM borskyp@lfhk.cuni.cz
RI Krejsek, Jan/AAQ-6561-2021; Holmannova, Drahomira/G-6260-2017; Rehacek,
   Vit/H-4564-2018; Fiala, Zdeněk/E-5962-2017; Borsky, Pavel/S-6307-2016;
   Svadlakova, Tereza/E-5562-2017; Malkova, Andrea/B-1013-2017; Palicka,
   Vladimir/N-1802-2017; Kremlacek, Jan/A-4313-2008; Borska,
   Lenka/S-6304-2016
OI Andrys, Ctirad/0000-0001-6489-8786; Borsky, Pavel/0000-0001-5253-2808;
   Svadlakova, Tereza/0000-0002-1581-5531; Holmannova,
   Drahomira/0000-0002-9865-9991; Malkova, Andrea/0000-0001-9444-8065;
   Palicka, Vladimir/0000-0001-7236-1647; Kremlacek,
   Jan/0000-0001-8641-4287; Borska, Lenka/0000-0002-8580-1485
FU Charles University, Faculty of Medicine in Hradec Kralove, the Czech
   Republic [Q40-09, Q40-10, Q40-11, SVV-260397/2017]
FX The authors acknowledge Mgr. Dana Knajflova for text proofreading and
   linguistics. The study was supported by Charles University, Faculty of
   Medicine in Hradec Kralove, the Czech Republic, by projects Q40-09,
   Q40-10, Q40-11, and SVV-260397/2017.
CR Abu-Farha M, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-016-0346-0
   Akimoto N, 2019, BIOMED REP, V11, P215, DOI 10.3892/br.2019.1243
   Albanesi C, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01549
   [Anonymous], 2013, compute.es: Compute Effect Sizes. R package version 0.2-2
   Asha K, 2017, INDIAN J MED RES, V146, P708, DOI 10.4103/ijmr.IJMR_717_16
   Borska L, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18112238
   Boutens L, 2018, DIABETOLOGIA, V61, P942, DOI 10.1007/s00125-017-4526-6
   Calan M, 2016, ENDOCRINE, V53, P271, DOI 10.1007/s12020-016-0875-z
   Chang HW, 2018, MICROBIOME, V6, DOI 10.1186/s40168-018-0533-1
   Chen CC, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-015-0326-9
   Dang FB, 2016, SCI REP-UK, V6, DOI 10.1038/srep36926
   Davidovici BB, 2010, J INVEST DERMATOL, V130, P1785, DOI 10.1038/jid.2010.103
   DiStefano JK, 2019, GENE, V681, P1, DOI 10.1016/j.gene.2018.09.041
   Fu JL, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-016-0461-y
   Fu ZY, 2014, SCI REP-UK, V4, DOI 10.1038/srep05013
   Gómez-Ambrosi J, 2014, J CLIN ENDOCR METAB, V99, pE2004, DOI 10.1210/jc.2014-1568
   Greco A. V., 2010, EUROPEAN REV MED PHA, V14
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Guo KF, 2015, OBESITY, V23, P793, DOI 10.1002/oby.21038
   Haller JF, 2017, J LIPID RES, V58, P1166, DOI 10.1194/jlr.M075689
   Hansson C, 2014, J IMMUNOL RES, V2014, DOI 10.1155/2014/696415
   Haridas PAN, 2015, J CLIN ENDOCR METAB, V100, pE1299, DOI 10.1210/jc.2015-1254
   Jerkic PS, 2018, EUR RESPIR J, V52, DOI 10.1183/13993003.congress-2018.PA4649
   Kadam DP, 2010, INDIAN J CLIN BIOCHE, V25, P388, DOI 10.1007/s12291-010-0043-9
   Karaman A, 2015, MUTAT RES-GEN TOX EN, V782, P30, DOI 10.1016/j.mrgentox.2015.03.009
   Kaur M., 2016, Int. J. Res. Dermatol, V2, P95, DOI [10.18203/issn.2455-4529.IntJResDermatol20164007, DOI 10.18203/issn.2455-4529.IntJResDermatol20164007, DOI 10.18203/ISSN.2455-4529.INTJRESDERMATOL20164007]
   Kaushik SB, 2019, J AM ACAD DERMATOL, V80, P27, DOI 10.1016/j.jaad.2018.06.057
   Kerkhoff C, 2012, EXP DERMATOL, V21, P822, DOI 10.1111/j.1600-0625.2012.01571.x
   Korman NJ, 2020, BRIT J DERMATOL, V182, P840, DOI 10.1111/bjd.18245
   Kovrov O, 2019, J LIPID RES, V60, P783, DOI 10.1194/jlr.M088807
   Lee YH, 2016, SCI REP-UK, V6, DOI 10.1038/srep24013
   Li HX, 2019, HORM-INT J ENDOCRINO, V18, P189, DOI 10.1007/s42000-019-00095-8
   Liao ZW, 2019, J CELL MOL MED, V23, P5737, DOI 10.1111/jcmm.14488
   Lin XR, 2016, FREE RADICAL RES, V50, P585, DOI 10.3109/10715762.2016.1162301
   Lips P, 2019, EUR J ENDOCRINOL, V180, pP23, DOI 10.1530/EJE-18-0736
   Loft ND, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0192010
   Lorthois I, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20071670
   Lu QY, 2017, GRAEF ARCH CLIN EXP, V255, P1515, DOI 10.1007/s00417-017-3676-z
   Luo MD, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00169
   Malkic Salihbegovic Eldina, 2015, Med Arch, V69, P85, DOI 10.5455/medarh.2015.69.85-87
   Mayer O, 2012, J HUM HYPERTENS, V26, P650, DOI 10.1038/jhh.2011.94
   Mysore R, 2017, J CLIN ENDOCR METAB, V102, P4001, DOI 10.1210/jc.2017-00453
   Ometto F, 2017, EXP BIOL MED, V242, P859, DOI 10.1177/1535370216681551
   Osmola-Mankowska A, 2018, POSTEP DERM ALERGOL, V35, P331, DOI 10.5114/ada.2018.77661
   Pedersen L, 2014, BMC CARDIOVASC DISOR, V14, DOI 10.1186/1471-2261-14-196
   Pirowska M, 2018, POSTEP DERM ALERGOL, V35, P360, DOI 10.5114/ada.2018.77665
   Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
   Rendon A, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20061475
   Russo L, 2018, IMMUNOLOGY, V155, P407, DOI 10.1111/imm.13002
   Shimizu I, 2014, CELL METAB, V20, P967, DOI 10.1016/j.cmet.2014.10.008
   Striz I, 2004, PHYSIOL RES, V53, P245, DOI 10.33549/physiolres.930448
   Taleb S, 2015, ARTERIOSCL THROM VAS, V35, P258, DOI 10.1161/ATVBAHA.114.303567
   Trebotic LK, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0136701
   Tuhan H, 2016, DIABETES RES CLIN PR, V114, P37, DOI 10.1016/j.diabres.2016.02.008
   van Greevenbroek Marleen M J, 2016, F1000Res, V5
   Villarroya F, 2018, J INTERN MED, V284, P492, DOI 10.1111/joim.12803
   Wang HY, 2016, SCI REP-UK, V6, DOI 10.1038/srep28431
   Wang WM, 2018, CHINESE MED J-PEKING, V131, P95, DOI 10.4103/0366-6999.221269
   Whyte JM, 2019, ARTHRITIS RES THER, V21, DOI 10.1186/s13075-019-1922-y
   Wickham H., 2009, GGPLOT2, DOI [10.1007/978-0-387-98141-3, DOI 10.1007/978-0-387-98141-3]
   Winer S, 2009, EUR J IMMUNOL, V39, P2629, DOI 10.1002/eji.200838893
   Yang LY, 2019, BIOMED RES INT, V2019, DOI 10.1155/2019/3814687
   Yi M, 2015, INT J ENDOCRINOL, V2015, DOI 10.1155/2015/479157
   Zaki AM, 2019, The Egyptian Journal of Hospital Medicine, V76, P3919
   Zhang Y, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-02355-w
   Zhou Q, 2009, FREE RADICAL BIO MED, V47, P891, DOI 10.1016/j.freeradbiomed.2009.06.033
NR 66
TC 15
Z9 15
U1 0
U2 5
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-8861
EI 2314-7156
J9 J IMMUNOL RES
JI J Immunol. Res.
PD MAY 20
PY 2020
VL 2020
AR 7352637
DI 10.1155/2020/7352637
PG 9
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA LU7SJ
UT WOS:000537950300001
PM 32537470
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Topel, ML
   Kelli, HM
   Lewis, TT
   Dunbar, SB
   Vaccarino, V
   Taylor, HA
   Quyyumi, AA
AF Topel, Matthew L.
   Kelli, Heval M.
   Lewis, Tene T.
   Dunbar, Sandra B.
   Vaccarino, Viola
   Taylor, Herman A.
   Quyyumi, Arshed A.
TI High neighborhood incarceration rate is associated with cardiometabolic
   disease in nonincarcerated black individuals
SO ANNALS OF EPIDEMIOLOGY
LA English
DT Article
DE Mass incarceration; Cardiovascular health; Racial disparities
ID MASS INCARCERATION; STRESS; HEALTH; RISK
AB Purpose: To examine the association between residence in neighborhoods with high rates of incarceration and cardiometabolic disease among nonincarcerated individuals.
   Methods: We used data from two community cohort studies (n = 1368) in Atlanta, Georgia - META-Health and Predictive Health (2005-2012)-to assess the association between neighborhood incarceration rate and cardiometabolic disease, adjusting for individual-level and neighborhood-level factors. We also examined the interaction between race and neighborhood incarceration rate.
   Results: Individuals living in neighborhoods with high incarceration rates were more likely to have dyslipidemia (odds ratio [OR] = 1.47; 95% confidence interval [CI] = 1.03-2.09) and metabolic syndrome (OR = 1.67; 95% CI = 1.07-2.59) in fully adjusted models. Interactions between race and neighborhood incarceration rate were significant; black individuals living in neighborhoods with high incarceration rates were more likely to have hypertension (OR = 1.59; 95% CI = 1.01 2.49), dyslipidemia (OR = 1.77; 95% CI = 1.12-2.80), and metabolic syndrome (OR = 1.80; 95% CI = 1.09-2.99).
   Conclusions: Black individuals living in neighborhoods with high rates of incarceration have worse cardiometabolic health profiles. Criminal justice reform may help reduce race-specific health disparities in the United States. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Topel, Matthew L.; Kelli, Heval M.; Quyyumi, Arshed A.] Emory Univ, Sch Med, Div Cardiol, Dept Med, 1462 Clifton Rd NE,Suite 507, Atlanta, GA 30322 USA.
   [Lewis, Tene T.; Vaccarino, Viola] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
   [Dunbar, Sandra B.; Taylor, Herman A.] Emory Univ, Nell Hodgson Woodruff Sch Nursing, Atlanta, GA 30322 USA.
   [Taylor, Herman A.] Morehouse Sch Med, Dept Med, Cardiovasc Res Inst, Atlanta, GA 30310 USA.
C3 Emory University; Emory University; Rollins School Public Health; Emory
   University; Morehouse School of Medicine
RP Quyyumi, AA (corresponding author), Emory Univ, Sch Med, Div Cardiol, Dept Med, 1462 Clifton Rd NE,Suite 507, Atlanta, GA 30322 USA.
EM aquyyum@emory.edu
RI Vaccarino, Viola/AAW-5600-2020; Lewis, Tene/JBS-7332-2023
OI Vaccarino, Laura Viola/0000-0002-9054-0654
FU National Institutes of Health [UL1 RR025008, U01 HL079156-01, T32
   HL130025-02]; American Heart Association Strategically Focused Research
   Network on Disparities [0000031288]
FX This research was supported by grants from the National Institutes of
   Health (UL1 RR025008, U01 HL079156-01, T32 HL130025-02) and the American
   Heart Association Strategically Focused Research Network on Disparities
   (Grant 0000031288).
CR [Anonymous], 2016, Diabetes Care, V39, P513
   [Anonymous], 2016, 250229 NCJ US DEP JU
   [Anonymous], JUST ATL SENT CORR
   [Anonymous], 250374 NCJ US DEP JU
   [Anonymous], 2015, Food access research atlas
   [Anonymous], CRIME RATE COMP MAP
   Cloud DH, 2014, AM J PUBLIC HEALTH, V104, P389, DOI 10.2105/AJPH.2013.301741
   Dulin-Keita A, 2012, J EPIDEMIOL COMMUN H, V66, P24, DOI 10.1136/jech.2009.092676
   Frank JW, 2013, AM J PUBLIC HEALTH, V103, pE38, DOI 10.2105/AJPH.2013.301255
   Grundy SM, 2002, CIRCULATION, V106, P3143, DOI 10.1161/circ.106.25.3143
   Hatzenbuehler ML, 2015, AM J PUBLIC HEALTH, V105, P138, DOI 10.2105/AJPH.2014.302184
   Havranek EP, 2015, CIRCULATION, V132, P873, DOI 10.1161/CIR.0000000000000228
   James PA, 2014, JAMA-J AM MED ASSOC, V311, P1809, DOI [10.1001/jama.2013.284427, 10.1001/jama.2014.4346]
   Kelli HM, 2017, CIRC-CARDIOVASC QUAL, V10, DOI 10.1161/CIRCOUTCOMES.116.003532
   Mitchell O, 2015, JUSTICE Q, V32, P288, DOI 10.1080/07418825.2012.761721
   Morris AA, 2011, PSYCHOSOM MED, V73, P462, DOI 10.1097/PSY.0b013e318222379c
   Schneiderman N, 2005, ANNU REV CLIN PSYCHO, V1, P607, DOI 10.1146/annurev.clinpsy.1.102803.144141
   von Känel R, 2007, J PSYCHIATR RES, V41, P744, DOI 10.1016/j.jpsychires.2006.06.009
   Wang EA, 2017, J AM COLL CARDIOL, V69, P2967, DOI 10.1016/j.jacc.2017.04.040
   Wang EA, 2009, ARCH INTERN MED, V169, P687, DOI 10.1001/archinternmed.2009.26
NR 20
TC 29
Z9 32
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1047-2797
EI 1873-2585
J9 ANN EPIDEMIOL
JI Ann. Epidemiol.
PD JUL
PY 2018
VL 28
IS 7
BP 489
EP 492
DI 10.1016/j.annepidem.2018.01.011
PG 4
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA GJ3VN
UT WOS:000435227000011
PM 29433977
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Fabbri, LM
   Luppi, F
   Beghé, B
   Rabe, KF
AF Fabbri, L. M.
   Luppi, F.
   Beghe, B.
   Rabe, K. F.
TI Complex chronic comorbidities of COPD
SO EUROPEAN RESPIRATORY JOURNAL
LA English
DT Review
DE bronchitis; chronic diseases; chronic heart failure; emphysema;
   inflammation; metabolic syndrome
ID OBSTRUCTIVE PULMONARY-DISEASE; NECROSIS-FACTOR-ALPHA; COMMUNITY-ACQUIRED
   PNEUMONIA; AIR-FLOW OBSTRUCTION; OXIDATIVE STRESS; LUNG-FUNCTION;
   CARDIOVASCULAR-DISEASE; SYSTEMIC INFLAMMATION; HEART-FAILURE;
   RISK-FACTORS
AB Chronic obstructive pulmonary disease (COPD) is defined by fixed airflow limitation associated with an abnormal pulmonary and systemic inflammatory response of the lungs to cigarette smoke.
   The systemic inflammation induced by smoking may also cause chronic heart failure, metabolic syndrome and other chronic diseases, which may contribute to the clinical manifestations and natural history of COPD. Thus COPD can no longer be considered a disease only of the lungs, as it is often associated with a wide variety of systemic consequences.
   A better understanding of the origin and consequences of systemic inflammation, and of potential therapies, will most likely lead to better care of patients with COPD. Medical textbooks and clinical guidelines still largely ignore the fact that COPD seldom occurs in isolation.
   As the diagnosis and assessment of severity of COPD may be greatly affected by the presence of comorbid conditions, the current authors believe that lung function measurement, noninvasive assessment of cardiovascular and metabolic functions, and circulating inflammatory markers (e.g. C-reactive protein) might help to better characterise these patients. Similarly, preventive and therapeutic interventions should address the patient in their complexity.
C1 [Fabbri, L. M.; Luppi, F.; Beghe, B.] Univ Modena & Reggio Emilla, Dept Oncol Haematol & Res Dis, I-41100 Modena, Italy.
   [Rabe, K. F.] Leiden Univ, Med Ctr, Dept Pulm, NL-2300 RA Leiden, Netherlands.
C3 Universita di Modena e Reggio Emilia; Leiden University; Leiden
   University Medical Center (LUMC); Leiden University - Excl LUMC
RP Fabbri, LM (corresponding author), Univ Modena & Reggio Emilla, Dept Oncol Haematol & Res Dis, Via Pozzo 71, I-41100 Modena, Italy.
EM fabbri.leonardo@unimore.it
RI Akdis, Cezmi/AAV-4844-2020; Rabe, Klaus/AAW-6296-2021; Luppi,
   Fabrizio/AAG-8099-2019; Fabbri, Leonardo/I-4055-2012
OI Akdis, Cezmi/0000-0001-8020-019X; LUPPI, FABRIZIO/0000-0001-5775-5947;
   Rabe, Klaus F./0000-0002-7020-1401; Fabbri, Leonardo/0000-0001-8894-1689
CR Agusti A, 2003, THORAX, V58, P832, DOI 10.1136/thorax.58.10.832
   Agusti Alvar, 2006, Proc Am Thorac Soc, V3, P478, DOI 10.1513/pats.200603-058MS
   Agusti Alvar G N, 2005, Proc Am Thorac Soc, V2, P367, DOI 10.1513/pats.200504-026SR
   Almirall J, 1999, EUR RESPIR J, V13, P349, DOI 10.1183/09031936.99.13234999
   [Anonymous], 1980, Ann Intern Med, V93, P391
   Baarends EM, 1997, THORAX, V52, P780, DOI 10.1136/thx.52.9.780
   Balasubramanian VP, 2006, CURR OPIN PULM MED, V12, P106, DOI 10.1097/01.mcp.0000208449.73101.ac
   Barnes PJ, 2004, PLOS MED, V1, P25, DOI 10.1371/journal.pmed.0010020
   Barreiro E, 2005, AM J RESP CRIT CARE, V171, P1116, DOI 10.1164/rccm.200407-887OC
   Barzilay JI, 2001, DIABETES, V50, P2384, DOI 10.2337/diabetes.50.10.2384
   Blacher J, 2005, NAT CLIN PRACT CARD, V2, P450, DOI 10.1038/ncpcardio0307
   Boyd CM, 2005, JAMA-J AM MED ASSOC, V294, P716, DOI 10.1001/jama.294.6.716
   Braunstein JB, 2003, J AM COLL CARDIOL, V42, P1226, DOI 10.1016/S0735-1097(03)00947-1
   Brody Jerome S, 2006, Proc Am Thorac Soc, V3, P535, DOI 10.1513/pats.200603-089MS
   Calverley PMA, 2007, NEW ENGL J MED, V356, P775, DOI 10.1056/NEJMoa063070
   Celli BR, 2004, EUR RESPIR J, V23, P932, DOI 10.1183/09031936.04.00014304
   Celli BR, 2004, NEW ENGL J MED, V350, P1005, DOI 10.1056/NEJMoa021322
   Chambers TJ, 2000, J PATHOL, V192, P4
   Charlson M, 2007, J GEN INTERN MED, V22, P464, DOI 10.1007/s11606-007-0130-7
   Cohen SBZ, 2007, AM J RESP CRIT CARE, V176, P113, DOI 10.1164/rccm.20011-1655PP
   Couillard A, 2003, AM J RESP CRIT CARE, V167, P1664, DOI 10.1164/rccm.200209-1028OC
   Creutzberg EC, 2000, AM J RESP CRIT CARE, V161, P745, DOI 10.1164/ajrccm.161.3.9808075
   Dahlström U, 2005, EUR J HEART FAIL, V7, P309, DOI 10.1016/j.ejheart.2005.01.008
   De Backer G, 2003, ATHEROSCLEROSIS, V171, P145, DOI 10.1016/j.atherosclerosis.2003.10.001
   Debigarté R, 2001, AM J RESP CRIT CARE, V164, P1712, DOI 10.1164/ajrccm.164.9.2104035
   Di Fazio I, 2006, J AM MED DIR ASSOC, V7, P208, DOI 10.1016/j.jamda.2005.12.008
   Epping-Jordan JE, 2005, LANCET, V366, P1667, DOI 10.1016/S0140-6736(05)67342-4
   Ezzati M, 2003, LANCET, V362, P847, DOI 10.1016/S0140-6736(03)14338-3
   Fabbri LM, 2006, BREATHE, V3, P40, DOI 10.1183/18106838.0301.40
   Fabbri LM, 2007, LANCET, V370, P797, DOI 10.1016/S0140-6736(07)61383-X
   FABBRI LM, 2007, P ERS RES SEM ROM FE
   Farr BM, 2000, RESP MED, V94, P422, DOI 10.1053/rmed.1999.0743
   FLENLEY DC, 1981, LANCET, V1, P681
   Ford ES, 2004, DIABETES CARE, V27, P2966, DOI 10.2337/diacare.27.12.2966
   Gan WQ, 2004, THORAX, V59, P574, DOI 10.1136/thx.2003.019588
   Gianni W, 2004, J CLIN ENDOCR METAB, V89, P6097, DOI 10.1210/jc.2004-0795
   Goldacre MJ, 2004, J PUBLIC HEALTH, V26, P8, DOI 10.1093/pubmed/fdh099
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hadley EC, 2005, CELL, V120, P557, DOI 10.1016/j.cell.2005.01.030
   Hansell AL, 2003, EUR RESPIR J, V22, P809, DOI 10.1183/09031936.03.00031403
   Hansson GK, 2005, NEW ENGL J MED, V352, P1685, DOI 10.1056/NEJMra043430
   Hjalmarsen A, 1996, DIABETES METAB, V22, P37
   Hogg J C, 2005, Exp Lung Res, V31 Suppl 1, P72
   Hole DJ, 1996, BRIT MED J, V313, P711
   Horton R, 2005, LANCET, V366, P1514, DOI 10.1016/S0140-6736(05)67454-5
   Huttunen R, 2007, BMC INFECT DIS, V7, DOI 10.1186/1471-2334-7-13
   Jeffery PK, 1998, THORAX, V53, P129, DOI 10.1136/thx.53.2.129
   Jensen HH, 2006, EUR RESPIR J, V28, P781, DOI 10.1183/09031936.06.00152205
   Jorgensen NR, 2007, RESP MED, V101, P177, DOI 10.1016/j.rmed.2006.03.029
   Kasahara Y, 2000, J CLIN INVEST, V106, P1311, DOI 10.1172/JCI10259
   Kasahara Y, 2000, AM J RESP CRIT CARE, V161, pA583
   Kasper D.L., 2007, Harrison's principles of internal medicine, V16th
   Kirkwood TBL, 2005, CELL, V120, P437, DOI 10.1016/j.cell.2005.01.027
   Koechlin C, 2004, EUR RESPIR J, V23, P538, DOI 10.1183/09031936.04.00069004
   Kotler DP, 2000, ANN INTERN MED, V133, P622, DOI 10.7326/0003-4819-133-8-200010170-00015
   Kriegsman DMW, 2004, J CLIN EPIDEMIOL, V57, P55, DOI 10.1016/S0895-4356(03)00258-0
   Le Jemtel TH, 2007, J AM COLL CARDIOL, V49, P171, DOI 10.1016/j.jacc.2006.08.046
   Lee LH, 2005, AM J RESP CRIT CARE, V172, P987, DOI 10.1164/rccm.200501-041OC
   Lee SH, 2007, NAT MED, V13, P567, DOI 10.1038/nm1583
   Litonjua AA, 2005, RESP MED, V99, P1583, DOI 10.1016/j.rmed.2005.03.023
   Lopez AD, 2006, LANCET, V367, P1747, DOI 10.1016/S0140-6736(06)68770-9
   MacCallum Peter K, 2005, Proc Am Thorac Soc, V2, P34
   MACNEE W, 1989, NEW ENGL J MED, V321, P924, DOI 10.1056/NEJM198910053211402
   MacNee W, 2001, TRENDS MOL MED, V7, P55, DOI 10.1016/S1471-4914(01)01912-8
   MacNee William, 2005, Proc Am Thorac Soc, V2, P50, DOI 10.1513/pats.200411-056SF
   Mal H, 2007, CURR OPIN PULM MED, V13, P114
   Mallia P, 2006, CHEST, V130, P1203, DOI 10.1378/chest.130.4.1203
   Maltais FS, 2003, AM J RESP CRIT CARE, V168, P916, DOI 10.1164/rccm.2307007
   Mancia G, 2003, J HYPERTENS, V21, P1011, DOI 10.1097/01.hjh.0000059051.65882.32
   Mannino DM, 2006, THORAX, V61, P472, DOI 10.1136/thx.2005.052449
   Mannino DM, 2006, EUR RESPIR J, V27, P627, DOI 10.1183/09031936.06.00024605
   Mannino DM, 2006, RESP MED, V100, P115, DOI 10.1016/j.rmed.2005.03.035
   Marquis Karine, 2005, J Cardiopulm Rehabil, V25, P226, DOI 10.1097/00008483-200507000-00010
   McEvoy CE, 1998, AM J RESP CRIT CARE, V157, P704, DOI 10.1164/ajrccm.157.3.9703080
   McGarvey LP, 2007, THORAX, V62, P411, DOI 10.1136/thx.2006.072348
   Morimoto K, 2006, J IMMUNOL, V176, P7657, DOI 10.4049/jimmunol.176.12.7657
   Morley JE, 2006, AM J CLIN NUTR, V83, P735, DOI 10.1093/ajcn/83.4.735
   MORRISON WL, 1988, CLIN SCI, V75, P415, DOI 10.1042/cs0750415
   Niewoehner Dennis E, 2002, Am J Respir Med, V1, P243
   Omori H, 2006, RESPIROLOGY, V11, P205, DOI 10.1111/j.1440-1843.2006.00827.x
   Orozco-Levi M, 2003, EUR RESPIR J, V22, p41S, DOI 10.1183/09031936.03.00004607
   Oudijk EJD, 2003, EUR RESPIR J, V22, p5S, DOI 10.1183/09031936.03.00004603a
   Pai JK, 2004, NEW ENGL J MED, V351, P2599, DOI 10.1056/NEJMoa040967
   Parameswaran Krishnan, 2006, Can Respir J, V13, P203
   Peeters A, 2003, ANN INTERN MED, V138, P24, DOI 10.7326/0003-4819-138-1-200301070-00008
   Pickup JC, 1997, DIABETOLOGIA, V40, P1286, DOI 10.1007/s001250050822
   Poulain M, 2006, CAN MED ASSOC J, V174, P1293, DOI 10.1503/cmaj.051299
   Praticò D, 1998, AM J RESP CRIT CARE, V158, P1709, DOI 10.1164/ajrccm.158.6.9709066
   Rabe KF, 2007, AM J RESP CRIT CARE, V176, P532, DOI 10.1164/rccm.200703-456SO
   Rabinovich RA, 2003, EUR RESPIR J, V21, P789, DOI 10.1183/09031936.03.00042702
   Rahman I, 1996, AM J RESP CRIT CARE, V154, P1055, DOI 10.1164/ajrccm.154.4.8887607
   Rana JS, 2004, DIABETES CARE, V27, P2478, DOI 10.2337/diacare.27.10.2478
   Reid MB, 2001, RESP RES, V2, P269, DOI 10.1186/rr67
   Repine JE, 1997, AM J RESP CRIT CARE, V156, P341, DOI 10.1164/ajrccm.156.2.9611013
   Ridker PM, 2000, NEW ENGL J MED, V342, P836, DOI 10.1056/NEJM200003233421202
   Rutten FH, 2005, BMJ-BRIT MED J, V331, P1379, DOI 10.1136/bmj.38664.661181.55
   Rutten FH, 2006, EUR J HEART FAIL, V8, P706, DOI 10.1016/j.ejheart.2006.01.010
   Rydén L, 2007, EUR HEART J, V28, P88, DOI [10.1093/eurheartj/ehm124, 10.1093/eurheartj/ehl260]
   Sabit R, 2007, AM J RESP CRIT CARE, V175, P1259, DOI 10.1164/rccm.200701-067OC
   Salpeter SR, 2004, CHEST, V125, P2309, DOI 10.1378/chest.125.6.2309
   Sauleda J, 2000, AM J RESP CRIT CARE, V161, P32, DOI 10.1164/ajrccm.161.1.9807079
   Schmidt MI, 1999, LANCET, V353, P1649, DOI 10.1016/S0140-6736(99)01046-6
   Schols AMWJ, 1996, THORAX, V51, P819, DOI 10.1136/thx.51.8.819
   SCHOLS AMWJ, 1995, AM J RESP CRIT CARE, V152, P1268, DOI 10.1164/ajrccm.152.4.7551381
   Schraeder C, 2005, J AMBUL CARE MANAG, V28, P201, DOI 10.1097/00004479-200507000-00003
   Sevenoaks MJ, 2006, RESP RES, V7, DOI 10.1186/1465-9921-7-70
   SHCOLS AMW, 2003, EUR RESP J S46, V22, pS81
   Sidney S, 2005, CHEST, V128, P2068, DOI 10.1378/chest.128.4.2068
   Sin DD, 2006, EUR RESPIR J, V28, P1245, DOI 10.1183/09031936.00133805
   Sin Don D, 2005, Proc Am Thorac Soc, V2, P8, DOI 10.1513/pats.200404-032MS
   Sin DD, 2007, CURR OPIN PULM MED, V13, P90
   Soriano JB, 2005, CHEST, V128, P2099, DOI 10.1378/chest.128.4.2099
   Stevens J, 2002, AM J EPIDEMIOL, V156, P832, DOI 10.1093/aje/kwf114
   Stewart CEH, 2004, J CELL PHYSIOL, V198, P237, DOI 10.1002/jcp.10387
   Strong K, 2006, INT J EPIDEMIOL, V35, P492, DOI 10.1093/ije/dyi315
   Sullivan AK, 2005, AM J RESP CRIT CARE, V172, P590, DOI 10.1164/rccm.200410-1332OC
   Swedberg K, 2005, EUR HEART J, V26, P1115, DOI 10.1093/eurheartj/ehi204
   Taichman DB, 2007, CLIN CHEST MED, V28, P1, DOI 10.1016/j.ccm.2006.11.012
   Takabatake N, 2000, AM J RESP CRIT CARE, V161, P1179, DOI 10.1164/ajrccm.161.4.9903022
   Tammemagi CM, 2003, INT J CANCER, V103, P792, DOI 10.1002/ijc.10882
   Taraseviciene-Stewart L, 2005, AM J RESP CRIT CARE, V171, P734, DOI 10.1164/rccm.200409-1275OC
   Tisdale MJ, 1997, J NATL CANCER I, V89, P1763, DOI 10.1093/jnci/89.23.1763
   Tuder RM, 2003, AM J RESP CELL MOL, V29, P88, DOI 10.1165/rcmb.2002-0228OC
   van Eeden SF, 2000, EUR RESPIR J, V15, P915, DOI 10.1034/j.1399-3003.2000.15e18.x
   van Eeden Stephan F, 2005, Proc Am Thorac Soc, V2, P61
   Van Gaal LF, 2006, NATURE, V444, P875, DOI 10.1038/nature05487
   VANDERHARST P, 2006, CARDIOVASC, V6, pE333
   Veeramachaneni Sateesh B, 2006, COPD, V3, P109
   Vernooy JH, 2002, AM J RESP CRIT CARE, V166, P1218, DOI 10.1164/rccm.2202023
   Walker CG, 2007, CLIN SCI, V112, P93, DOI 10.1042/CS20060150
   Walters JA, 2005, COCHRANE DB SYST REV, V3
   Wang PS, 2005, HYPERTENSION, V46, P273, DOI 10.1161/01.HYP.0000172753.96583.e1
   Young RP, 2007, EUR RESPIR J, V30, P616, DOI 10.1183/09031936.00021707
NR 133
TC 481
Z9 508
U1 0
U2 35
PU EUROPEAN RESPIRATORY SOC JOURNALS LTD
PI SHEFFIELD
PA 442 GLOSSOP RD, SHEFFIELD S10 2PX, ENGLAND
SN 0903-1936
EI 1399-3003
J9 EUR RESPIR J
JI Eur. Resp. J.
PD JAN
PY 2008
VL 31
IS 1
BP 204
EP 212
DI 10.1183/09031936.00114307
PG 9
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA 251RG
UT WOS:000252390800027
PM 18166598
DA 2025-06-11
ER

PT J
AU Tigno, XT
   Ding, SY
   Erwin, JM
   Aslam, S
   Hansen, BC
AF Tigno, Xenia T.
   Ding, Shi Ying
   Erwin, Joseph M.
   Aslam, Sadaf
   Hansen, Barbara C.
TI Understanding type 2 diabetes and aging: lessons from nonhuman primates
SO ASIAN BIOMEDICINE
LA English
DT Review
DE aging; diabetes; metabolic syndrome; obesity; nonhuman primates; rhesus
   macaques
ID AGE-RELATED-CHANGES; RHESUS-MONKEYS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; STRESS; HYPERINSULINEMIA; RESTRICTION; HYPERTROPHY; PARAMETERS
AB Background: The increase in global prevalence of obesity and diabetes, and the growth of the elderly population worldwide emphasize the biomedical research need for an animal model which exhibits close similarity to human disease and aging processes. The rhesus monkey develops obesity and type 2 diabetes spontaneously and naturally when ad libitum fed, within a lifespan which is about a third that of the human.
   Objective: To characterize the genetic, structural, biochemical and physiological changes occurring in monkeys who age successfully and in those who develop obesity and type 2 diabetes.
   Results: The rhesus monkey demonstrates the same signs and symptoms of type 2 diabetes, including macro- and microvascular complications, as observed in humans. Age-related changes, potential biomarkers, and proposed biochemical pathways of aging can be readily investigated, with outcomes very similar to those in humans.
   Conclusion: The rhesus monkey model imparts valuable insights to normal and pathological processes accompanying aging and type 2 diabetes. It also provides a valuable tool by which to test novel therapeutic interventions which otherwise can not be performed in humans due to ethical considerations, but where results are highly translatable.
C1 [Tigno, Xenia T.; Aslam, Sadaf; Hansen, Barbara C.] Univ S Florida, Coll Med, Tampa, FL 33612 USA.
   [Ding, Shi Ying] Univ Maryland, Sch Med, Baltimore, MD 21201 USA.
   [Erwin, Joseph M.] Virginia Polytech Inst & State Univ, Virginia Maryland Reg Coll Vet Med, Blacksburg, VA 24060 USA.
C3 State University System of Florida; University of South Florida;
   University System of Maryland; University of Maryland Baltimore;
   Virginia Polytechnic Institute & State University
RP Tigno, XT (corresponding author), Univ S Florida, Coll Med, Tampa, FL 33612 USA.
EM xtigno@yahoo.com
RI Hansen, Barbara/J-8723-2012
CR [Anonymous], GLOBAL BURDEN DIABET
   [Anonymous], MEDGENMED
   Björntorp P, 2002, NOVART FDN SYMP, V242, P46
   BJORNTORP P, 2002, NOVART FDN SYMP, V242, P58
   Bodkin NL, 2003, HORM METAB RES, V35, P617, DOI 10.1055/s-2003-43510
   BODKIN NL, 1995, J GERONTOL A-BIOL, V50, pB142, DOI 10.1093/gerona/50A.3.B142
   BODKIN NL, 1991, METABOLISM, V40, P1131, DOI 10.1016/0026-0495(91)90206-C
   BODKIN NL, 1993, INT J OBESITY, V17, P53
   BODKIN NL, 1989, AM J PHYSIOL, V256, pE676, DOI 10.1152/ajpendo.1989.256.5.E676
   CORNBLATH DR, 1989, DIABETES, V38, P1365, DOI 10.2337/diabetes.38.11.1365
   Cusumano AM, 2002, AM J KIDNEY DIS, V40, P1075, DOI 10.1053/ajkd.2002.36348
   DeLany JP, 1999, J GERONTOL A-BIOL, V54, pB5, DOI 10.1093/gerona/54.1.B5
   DELANY JP, 1935, J GERONTOL A-BIOL, V54, pB5
   Ding SY, 2007, METABOLISM, V56, P1334, DOI 10.1016/j.metabol.2007.05.019
   Ding SY, 2007, METABOLISM, V56, P838, DOI 10.1016/j.metabol.2007.01.015
   Erwin JM, 2004, J GERONTOL A-BIOL, V59, P424
   Gavin JR, 1997, DIABETES CARE, V20, P1183
   Genuth S, 2003, DIABETES CARE, V26, P3160
   HANSEN BC, 1990, AM J PHYSIOL, V259, pR612, DOI 10.1152/ajpregu.1990.259.3.R612
   HANSEN BC, 1986, DIABETOLOGIA, V29, P713, DOI 10.1007/BF00870281
   Hansen BC, 1999, TOXICOL SCI, V52, P56, DOI 10.1093/toxsci/52.suppl_1.56
   HANSEN BC, 2004, HDB OBESITY, P283
   HANSEN BC, 2004, DIABETES MELLITUS FU, P1059
   HANSEN BC, 2007, ANIMAL MODELS DIABET, P251
   Johnson MA, 2005, EXP EYE RES, V80, P37, DOI 10.1016/j.exer.2004.08.006
   Kharitonenkov A, 2007, ENDOCRINOLOGY, V148, P774, DOI 10.1210/en.2006-1168
   Kim SY, 2005, DIABETES, V54, P1534, DOI 10.2337/diabetes.54.5.1534
   Kim SY, 2004, INVEST OPHTH VIS SCI, V45, P4543, DOI 10.1167/iovs.04-0519
   Landfield P W, 1978, Adv Exp Med Biol, V113, P179
   Laron Z, 2002, NOVART FDN SYMP, V242, P125
   Laron Z, 2002, NOVART FDN SYMP, V242, P137
   Oliver WR, 2001, P NATL ACAD SCI USA, V98, P5306, DOI 10.1073/pnas.091021198
   Ortmeyer H K, 2000, Int J Exp Diabetes Res, V1, P195, DOI 10.1155/EDR.2000.195
   Ortmeyer H K, 1994, Obes Res, V2, P549
   Paré M, 2007, J COMP NEUROL, V501, P543, DOI 10.1002/cne.21262
   SAPOLSKY RM, 1991, BIOL PSYCHIAT, V30, P1008, DOI 10.1016/0006-3223(91)90121-2
   SAPOLSKY RM, 1986, ENDOCR REV, V7, P284, DOI 10.1210/edrv-7-3-284
   Sapolsky RM, 1999, EXP GERONTOL, V34, P721, DOI 10.1016/S0531-5565(99)00047-9
   Tigno XT, 2006, CLIN HEMORHEOL MICRO, V34, P273
   Tigno XT, 2004, J GERONTOL A-BIOL, V59, P1081, DOI 10.1093/gerona/59.11.1081
   TIGNO XT, 2005, HDB EXPT ANIMALS, P451
   Wild S, 2004, DIABETES CARE, V27, P1047, DOI 10.2337/diacare.27.5.1047
   Winegar DA, 2001, J LIPID RES, V42, P1543
   Young AA, 1999, DIABETES, V48, P1026, DOI 10.2337/diabetes.48.5.1026
NR 44
TC 2
Z9 2
U1 0
U2 2
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1905-7415
EI 1875-855X
J9 ASIAN BIOMED
JI Asian Biomed.
PD DEC
PY 2007
VL 1
IS 4
BP 359
EP 376
PG 18
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 318UQ
UT WOS:000257118700003
DA 2025-06-11
ER

PT J
AU Eriksson, MD
   Eriksson, JG
   Kautiainen, H
   Salonen, MK
   Mikkola, TM
   Kajantie, E
   Wasenius, N
   von Bonsdorff, M
   Korhonen, P
   Laine, MK
AF Eriksson, Mia D.
   Eriksson, Johan G.
   Kautiainen, Hannu
   Salonen, Minna K.
   Mikkola, Tuija M.
   Kajantie, Eero
   Wasenius, Niko
   von Bonsdorff, Mikaela
   Korhonen, Paivi
   Laine, Merja K.
TI Higher carotid-radial pulse wave velocity is associated with
   non-melancholic depressive symptoms in men - findings from Helsinki
   Birth Cohort Study
SO ANNALS OF MEDICINE
LA English
DT Article
DE Cohort study; comorbidity; depression; depressive disorder; pulse wave
   velocity
ID SMALL-VESSEL DISEASE; MIDDLE-AGED MEN; ARTERIAL STIFFNESS; ENDOTHELIAL
   DYSFUNCTION; VASCULAR DEPRESSION; METABOLIC SYNDROME; AORTIC STIFFNESS;
   BLOOD-PRESSURE; POPULATION; RISK
AB Background
   Depression and cardiovascular disease (CVD) are major causes of global disease burden that are interrelated through mostly unknown mechanisms. We studied the relationship of melancholic and non-melancholic depressive symptoms with arterial stiffness, an important underlying mechanism of CVD.
   Methods
   The Helsinki Birth Cohort Study recruited 683 previously extensively phenotyped subjects for this sub-study. Cross-sectional data along with responses regarding depressive symptoms were obtained for each participant. For evaluation of depressive symptoms, the Beck Depression Inventory (BDI)and subscales were used to measure melancholic and non-melancholic depressive symptoms. Arterial stiffness was assessed as pulse wave velocity (PWV) that was measured between the carotid and radial artery, and carotid and femoral artery.
   Results
   Of the participants, 532 scored <10 on the BDI and were classified as not having depressive symptoms. Of the 151 participants that scored >= 10 on the BDI, 122 were classified as having non-melancholic depressive symptoms and 29 as having melancholic depressive symptoms. Men had higher carotid-radial PWV (crPWV) values than women (p < .001). A positive relationship between BDI scores and crPWV (p < .001) was found in men. We also found higher crPWV in men with non-melancholic depressive symptoms compared to all others. No such differences were found in women.
   Discussion
   Arterial stiffness has a relationship with depressive symptoms and subtypes of depressive symptoms, at least in men. There is a significant relationship between higher PWV and non-melancholic depressive symptoms in men. Due to the intricate nature of the disease causality or directionality is impossible to infer solely based on this study. Further studies into the subtypes of depressive symptoms may be of benefit to understanding depression. KEY MESSAGES
   It is known that arterial stiffness contributes to cardiovascular disease, and is associated with depression.
   Higher Beck Depression Inventory scores are associated with higher carotid-radial pulse wave velocity in men.
   Non-melancholic depressive symptoms are associated with higher carotid-radial pulse wave velocity in men.
C1 [Eriksson, Mia D.] Helsinki Univ Hosp HUS, Primary Hlth Care Unit, Helsinki, Finland.
   [Eriksson, Johan G.; Kautiainen, Hannu; Salonen, Minna K.; Mikkola, Tuija M.; Wasenius, Niko; von Bonsdorff, Mikaela; Laine, Merja K.] Folkhalsan Res Ctr, Helsinki, Finland.
   [Eriksson, Johan G.; Wasenius, Niko; Laine, Merja K.] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.
   [Eriksson, Johan G.; Wasenius, Niko; Laine, Merja K.] Helsinki Univ Hosp, Helsinki, Finland.
   [Eriksson, Johan G.] Natl Univ Singapore, Dept Obstet & Gynecol, Singapore, Singapore.
   [Eriksson, Johan G.] Natl Univ Singapore, Human Potential Translat Res Programme Yong Loo L, Singapore, Singapore.
   [Eriksson, Johan G.] ASTAR, Singapore Inst Clin Sci SICS, Singapore, Singapore.
   [Kautiainen, Hannu] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
   [Salonen, Minna K.] Finnish Inst Hlth & Welf, Publ Hlth Promot Unit, Dept Publ Hlth Solut, Helsinki, Finland.
   [Mikkola, Tuija M.] Univ Helsinki, Fac Med, Clinicum, Helsinki, Finland.
   [Kajantie, Eero] Oulu Univ Hosp, MRC Oulu, PEDEGO Res Unit, Oulu, Finland.
   [Kajantie, Eero] Univ Oulu, Oulu, Finland.
   [Kajantie, Eero] Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway.
   [von Bonsdorff, Mikaela] Univ Jyvaskyla, Gerontol Res Ctr, Jyvaskyla, Finland.
   [von Bonsdorff, Mikaela] Univ Jyvaskyla, Fac Sport & Hlth Sci, Jyvaskyla, Finland.
   [Korhonen, Paivi] Turku Univ Hosp, Dept Gen Practice, Turku, Finland.
   [Korhonen, Paivi] Univ Turku, Turku, Finland.
C3 Folkhalsan Research Center; University of Helsinki; University of
   Helsinki; Helsinki University Central Hospital; National University of
   Singapore; National University of Singapore; Agency for Science
   Technology & Research (A*STAR); A*STAR - Singapore Institute for
   Clinical Sciences (SICS); University of Eastern Finland; University of
   Helsinki; University of Oulu; University of Oulu; Norwegian University
   of Science & Technology (NTNU); University of Jyvaskyla; University of
   Jyvaskyla; University of Turku; University of Turku
RP Laine, MK (corresponding author), Folkhalsan Res Ctr, Helsinki, Finland.; Laine, MK (corresponding author), Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.; Laine, MK (corresponding author), Helsinki Univ Hosp, Helsinki, Finland.
EM merja.k.laine@helsinki.fi
RI Gibbs, J. Raphael/A-3984-2010; Wasenius, Niko/AAE-8927-2020; von
   Bonsdorff, Mikaela/A-5218-2015; Mikkola, Tuija/L-2835-2014; /H-8100-2016
OI Eriksson, Johan/0000-0002-2516-2060; von Bonsdorff,
   Mikaela/0000-0001-8530-5230; Eriksson, Mia/0000-0001-8968-8304;
   Wasenius, Niko/0000-0002-9007-6660; Mikkola, Tuija/0000-0003-0885-2788;
   /0000-0002-1848-1514
FU Finska Lakaresallskapet; Finnish Special Governmental Subsidy for Health
   Sciences; Academy of Finland [126775, 127437, 129255, 129306, 129907,
   130326, 134791, 209072, 210595, 213225, 263924, 275074, 315690];
   Samfundet Folkhalsan; Liv och Halsa; EU FP7 [Developmental Origins of
   Healthy Aging (DORIAN)] [278603]; EU H2020PHC-2014-Dyna Health grant
   [633595]; EU Horizon 2020 Award [733206]; European Commission, Horizon
   2020 award [733280]; RECAP; Foundation for Cardiovascular Research;
   Foundation for Diabetes Research; Foundation for Paediatric Research;
   Novo Nordisk Foundation; Signe and Ane Gyllenberg Foundation; Academy of
   Finland (AKA) [209072, 210595, 275074, 213225] Funding Source: Academy
   of Finland (AKA)
FX The HBCS has been supported by grants from Finska Lakaresallskapet, the
   Finnish Special Governmental Subsidy for Health Sciences, Academy of
   Finland [126775, 127437, 129255, 129306, 129907, 130326, 134791, 209072,
   210595, 213225, 263924, 275074 and 315690], Samfundet Folkhalsan, Liv
   och Halsa, EU FP7 [Developmental Origins of Healthy Aging (DORIAN)]
   project number 278603, and EU H2020PHC-2014-Dyna Health grant [633595]
   and EU Horizon 2020 Award [733206]. LIFECYCLE (all for the Helsinki
   Birth Cohort Study), European Commission, Horizon 2020 award [733280].
   RECAP, Foundation for Cardiovascular Research, Foundation for Diabetes
   Research, Foundation for Paediatric Research, Novo Nordisk Foundation,
   Signe and Ane Gyllenberg Foundation.
CR Ainsworth BE, 2011, MED SCI SPORT EXER, V43, P1575, DOI 10.1249/MSS.0b013e31821ece12
   Akil H, 2018, NEUROSCI BIOBEHAV R, V84, P272, DOI 10.1016/j.neubiorev.2017.08.019
   Alexopoulos GS, 1997, ARCH GEN PSYCHIAT, V54, P915
   Barker DJP, 2005, NEW ENGL J MED, V353, P1802, DOI 10.1056/NEJMoa044160
   BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561, DOI 10.1001/archpsyc.1961.01710120031004
   BECK AT, 1988, CLIN PSYCHOL REV, V8, P77, DOI 10.1016/0272-7358(88)90050-5
   Buckner RL, 2004, NEURON, V44, P195, DOI 10.1016/j.neuron.2004.09.006
   CHARLSON ME, 1987, J CHRON DIS, V40, P373, DOI 10.1016/0021-9681(87)90171-8
   Cohn JN, 2006, CIRCULATION, V113, P601, DOI 10.1161/CIRCULATIONAHA.105.600866
   Covic A, 2015, HYPERTENSION, V65, P289, DOI 10.1161/HYPERTENSIONAHA.114.04678
   Cypiene A, 2009, LUPUS, V18, P522, DOI 10.1177/0961203308099625
   Cypiene A, 2008, CLIN RHEUMATOL, V27, P1517, DOI 10.1007/s10067-008-0958-1
   Duprez DA, 2004, AM J HYPERTENS, V17, P647, DOI 10.1016/j.amjhyper.2004.03.671
   Elias MF, 2009, HYPERTENSION, V53, P668, DOI 10.1161/HYPERTENSIONAHA.108.126342
   Eriksson JG, 2016, ANN MED, V48, P456, DOI 10.1080/07853890.2016.1193786
   Eriksson JG, 2010, AM J HUM BIOL, V22, P330, DOI 10.1002/ajhb.20995
   Fewlass DC, 2004, FASEB J, V18, P1870, DOI 10.1096/fj.04-2572com
   Fortier C, 2017, HYPERTENSION, V69, P96, DOI 10.1161/HYPERTENSIONAHA.116.08409
   FOSSATI P, 1982, CLIN CHEM, V28, P2077
   Franklin SS, 1997, CIRCULATION, V96, P308
   GIANNATTASIO C, 1995, HYPERTENSION, V26, P491, DOI 10.1161/01.HYP.26.3.491
   Giannattasio C, 2005, HYPERTENSION, V45, P608, DOI 10.1161/01.HYP.0000157368.09939.88
   Harrell Jr FE, 2022, Regression modeling strategies
   Harshfield EL., 2020, J AMER MED ASSOC, V324, P2396, DOI DOI 10.1001/jama.2020.23068
   Heitzer T, 2001, CIRCULATION, V104, P2673, DOI 10.1161/hc4601.099485
   Henskens LHG, 2008, HYPERTENSION, V52, P1120, DOI 10.1161/HYPERTENSIONAHA.108.119024
   Hickson SS, 2016, HYPERTENS RES, V39, P723, DOI 10.1038/hr.2016.64
   Huybrechts SAM, 2011, J HYPERTENS, V29, P1577, DOI 10.1097/HJH.0b013e3283487841
   Jannasz Iwona, 2019, Pol Merkur Lekarski, V46, P257
   Johnson TE, 2006, EXP GERONTOL, V41, P1243, DOI 10.1016/j.exger.2006.09.006
   Kearney-Schwartz A, 2009, STROKE, V40, P1229, DOI 10.1161/STROKEAHA.108.532853
   Krishnan KRR, 1997, AM J PSYCHIAT, V154, P497
   LAKKA TA, 1992, INT J EPIDEMIOL, V21, P467, DOI 10.1093/ije/21.3.467
   Lamers F, 2013, MOL PSYCHIATR, V18, P692, DOI 10.1038/mp.2012.144
   Lewis TT, 2010, J GERONTOL A-BIOL, V65, P1079, DOI 10.1093/gerona/glq089
   LIE RF, 1976, CLIN CHEM, V22, P1627
   Malhi GS, 2018, LANCET, V392, P2299, DOI 10.1016/S0140-6736(18)31948-2
   Mancia G, 2007, J HYPERTENS, V25, P1749, DOI 10.1097/01.hjh.0000280180.80455.83
   Marioni RE, 2010, DIABETES, V59, P710, DOI 10.2337/db09-1163
   Markkula Niina, 2017, Duodecim, V133, P275
   Mitchell GF, 2014, HYPERTENSION, V64, P13, DOI 10.1161/HYPERTENSIONAHA.114.00921
   Mitchell GF, 2011, BRAIN, V134, P3398, DOI 10.1093/brain/awr253
   Mitchell GF, 2002, J AM COLL CARDIOL, V39, p139A
   Ohmine T, 2008, HYPERTENS RES, V31, P75, DOI 10.1291/hypres.31.75
   Onete V, 2018, J PSYCHIATR NEUROSCI, V43, P111, DOI 10.1503/jpn.160246
   Organization W.H., 2017, Depression and other common mental disorders: Global health estimates
   Penninx BWJH, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-129
   Pugh KG, 2002, NEUROBIOL AGING, V23, P421, DOI 10.1016/S0197-4580(01)00319-0
   Salaycik KJ, 2007, STROKE, V38, P16, DOI 10.1161/01.STR.0000251695.39877.ca
   Segers P, 2007, HYPERTENSION, V49, P1248, DOI 10.1161/HYPERTENSIONAHA.106.085480
   Seppälä J, 2012, J AFFECT DISORDERS, V138, P473, DOI 10.1016/j.jad.2012.01.007
   Seppälä J, 2012, J AFFECT DISORDERS, V136, P543, DOI 10.1016/j.jad.2011.10.032
   Taylor WD, 2013, MOL PSYCHIATR, V18, P963, DOI 10.1038/mp.2013.20
   Thomas O, 2019, J STROKE CEREBROVASC, V28, P1252, DOI 10.1016/j.jstrokecerebrovasdis.2019.01.020
   Tiemeier H, 2003, J AM GERIATR SOC, V51, P1105, DOI 10.1046/j.1532-5415.2003.51359.x
   Van Bortel LM, 2012, J HYPERTENS, V30, P445, DOI 10.1097/HJH.0b013e32834fa8b0
   van Sloten TT, 2014, PSYCHOL MED, V44, P1403, DOI 10.1017/S0033291713002043
   van Sloten TT, 2016, J PSYCHIATR NEUROSCI, V41, P162, DOI 10.1503/jpn.140334
   van Sloten TT, 2015, NEUROSCI BIOBEHAV R, V53, P121, DOI 10.1016/j.neubiorev.2015.03.011
   Vanhala M, 2009, ACTA PSYCHIAT SCAND, V119, P137, DOI 10.1111/j.1600-0447.2008.01283.x
   World Health Organization, 2017, Global Hepatitis Report 2017
   Zanoli L, 2020, J HYPERTENS, V38, P2008, DOI 10.1097/HJH.0000000000002517
   Zanoli L, 2020, J HYPERTENS, V38, P1682, DOI 10.1097/HJH.0000000000002508
   Zanoli L, 2018, EUR J INTERN MED, V47, P36, DOI 10.1016/j.ejim.2017.08.020
   Zanoli L, 2012, J HYPERTENS, V30, P1775, DOI 10.1097/HJH.0b013e3283568abd
NR 65
TC 7
Z9 7
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PD JAN 1
PY 2021
VL 53
IS 1
BP 531
EP 540
DI 10.1080/07853890.2021.1904277
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA RD0VC
UT WOS:000633206100001
PM 33769182
OA Green Published
DA 2025-06-11
ER

PT J
AU Ayoub, HM
   McDonald, MR
   Sullivan, JA
   Tsao, R
   Meckling, KA
AF Ayoub, Hala M.
   McDonald, Mary Ruth
   Sullivan, James Alan
   Tsao, Rong
   Meckling, Kelly A.
TI Proteomic Profiles of Adipose and Liver Tissues from an Animal Model of
   Metabolic Syndrome Fed Purple Vegetables
SO NUTRIENTS
LA English
DT Article
DE obesity; hypertension; insulin resistance; high fat diet; carrots;
   potatoes; proteomic analyses
ID HIGH-FAT-DIET; BILE-ACID SYNTHESIS; ATP-CITRATE LYASE; FED RAT MODEL;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; AMELIORATES HYPERGLYCEMIA;
   CHOLESTEROL EFFLUX; LIPID DROPLETS; TART CHERRY
AB Metabolic Syndrome (MetS) is a complex disorder that predisposes an individual to Cardiovascular Diseases and type 2 Diabetes Mellitus. Proteomics and bioinformatics have proven to be an effective tool to study complex diseases and mechanisms of action of nutrients. We previously showed that substitution of the majority of carbohydrate in a high fat diet by purple potatoes (PP) or purple carrots (PC) improved insulin sensitivity and hypertension in an animal model of MetS (obese Zucker rats) compared to a control sucrose-rich diet. In the current study, we used TMT 10plex mass tag combined with LC-MS/MS technique to study proteomic modulation in the liver (n = 3 samples/diet) and adipose tissue (n = 3 samples/diet) of high fat diet-fed rats with or without substituting sucrose for purple vegetables, followed by functional enrichment analysis, in an attempt to elucidate potential molecular mechanisms responsible for the phenotypic changes seen with purple vegetable feeding. Protein folding, lipid metabolism and cholesterol efflux were identified as the main modulated biological themes in adipose tissue, whereas lipid metabolism, carbohydrate metabolism and oxidative stress were the main modulated themes in liver. We propose that enhanced protein folding, increased cholesterol efflux and higher free fatty acid (FFA) re-esterification are mechanisms by which PP and PC positively modulate MetS pathologies in adipose tissue, whereas, decreased de novo lipogenesis, oxidative stress and FFA uptake, are responsible for the beneficial effects in liver. In conclusion, we provide molecular evidence for the reported metabolic health benefits of purple carrots and potatoes and validate that these vegetables are good choices to replace other simple carbohydrate sources for better metabolic health.
C1 [Ayoub, Hala M.; Meckling, Kelly A.] Univ Guelph, Dept Human Hlth & Nutr Sci, Guelph, ON N1G 2W1, Canada.
   [McDonald, Mary Ruth; Sullivan, James Alan] Univ Guelph, Dept Plant Agr, Guelph, ON N1G 2W1, Canada.
   [Tsao, Rong] Agr & Agri Food Canada, Guelph Res & Dev Ctr, Guelph, ON N1G 5C9, Canada.
C3 University of Guelph; University of Guelph; Agriculture & Agri Food
   Canada
RP Meckling, KA (corresponding author), Univ Guelph, Dept Human Hlth & Nutr Sci, Guelph, ON N1G 2W1, Canada.
EM hayoub@uoguelph.ca; mrmcdona@uoguelph.ca; asulliva@uoguelph.ca;
   Rong.Cao@agr.gc.ca; kmecklin@uoguelph.ca
RI Tsao, Rong/I-3096-2014; McDonald, Mary Ruth/R-8809-2019
OI McDonald, Mary Ruth/0000-0002-2881-815X
FU Ontario Ministry of Agriculture, Food and Rural Affairs (OMAFRA);
   OMAFRA-U of G Highly Qualified Personnel (HQP) Scholarship
FX This work was funded by Ontario Ministry of Agriculture, Food and Rural
   Affairs (OMAFRA). H.A. was supported by OMAFRA-U of G Highly Qualified
   Personnel (HQP) Scholarship.
CR Adeva-Andany MM, 2016, BBA CLIN, V5, P85, DOI 10.1016/j.bbacli.2016.02.001
   Ahmadian M, 2010, INT J BIOCHEM CELL B, V42, P555, DOI 10.1016/j.biocel.2009.12.009
   Ahmed M, 2010, OBESITY, V18, P27, DOI 10.1038/oby.2009.208
   [Anonymous], 2002, Biochemistry: International Version
   [Anonymous], REACTIVE OXYGEN SPEC
   Ayoub HM, 2017, J MED FOOD, V20, P1240, DOI 10.1089/jmf.2017.0025
   Bauer DE, 2005, ONCOGENE, V24, P6314, DOI 10.1038/sj.onc.1208773
   Bouwman FG, 2009, J PROTEOME RES, V8, P5532, DOI 10.1021/pr900606m
   Brasaemle DL, 2007, J LIPID RES, V48, P2547, DOI 10.1194/jlr.R700014-JLR200
   Bu SY, 2010, J LIPID RES, V51, P3270, DOI 10.1194/jlr.M009407
   Cao JS, 2006, P NATL ACAD SCI USA, V103, P19695, DOI 10.1073/pnas.0609140103
   Castellani L, 2015, J APPL PHYSIOL, V119, P1347, DOI 10.1152/japplphysiol.00551.2015
   Chelikani P, 2004, CELL MOL LIFE SCI, V61, P192, DOI 10.1007/s00018-003-3206-5
   Coleman RA, 2002, J NUTR, V132, P2123, DOI 10.1093/jn/132.8.2123
   DeFuria J, 2009, J NUTR, V139, P1510, DOI 10.3945/jn.109.105155
   Eltoweissy M, 2011, MOL BIOSYST, V7, P1277, DOI 10.1039/c0mb00116c
   Flamment M, 2012, TRENDS ENDOCRIN MET, V23, P381, DOI 10.1016/j.tem.2012.06.003
   Franckhauser S, 2002, DIABETES, V51, P624, DOI 10.2337/diabetes.51.3.624
   Gall J, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.116.004808
   Gallagher EJ, 2010, MT SINAI J MED, V77, P511, DOI 10.1002/msj.20212
   Gomer CJ, 1996, CANCER RES, V56, P2355
   Hegardt FG, 1999, BIOCHEM J, V338, P569, DOI 10.1042/0264-6021:3380569
   Hsieh CC, 2016, J FOOD DRUG ANAL, V24, P754, DOI 10.1016/j.jfda.2016.03.005
   Huang DW, 2009, NAT PROTOC, V4, P44, DOI 10.1038/nprot.2008.211
   Huber MD, 2013, J CELL BIOL, V203, P427, DOI 10.1083/jcb.201305076
   Jernås M, 2009, BIOCHEM BIOPH RES CO, V383, P63, DOI 10.1016/j.bbrc.2009.03.120
   Kaspar KL, 2011, J NUTR, V141, P108, DOI 10.3945/jn.110.128074
   Kim EY, 2015, INT J MOL SCI, V16, P4581, DOI 10.3390/ijms16034581
   KONDO KH, 1994, EUR J BIOCHEM, V219, P357, DOI 10.1111/j.1432-1033.1994.tb19947.x
   Larsson M, 2013, J BIOL CHEM, V288, P33997, DOI 10.1074/jbc.M113.495366
   Lass A, 2006, CELL METAB, V3, P309, DOI 10.1016/j.cmet.2006.03.005
   Lewis GF, 2005, CIRC RES, V96, P1221, DOI 10.1161/01.RES.0000170946.56981.5c
   Li LO, 2009, J BIOL CHEM, V284, P27816, DOI 10.1074/jbc.M109.022467
   Lin YC, 2007, CARDIOVASC RES, V75, P575, DOI 10.1016/j.cardiores.2007.04.012
   Liu WS, 2011, PLOS ONE, V6, DOI [10.1371/journal.pone.0024363, 10.1371/journal.pone.0024406]
   Lu SC, 2013, BBA-GEN SUBJECTS, V1830, P3143, DOI 10.1016/j.bbagen.2012.09.008
   Luo Moulun, 2012, J Proteomics Bioinform, V5, P60, DOI 10.4172/jpb.1000214
   Macpherson REK, 2015, MED SCI SPORT EXER, V47, P2034, DOI 10.1249/MSS.0000000000000660
   MacPherson REK, 2015, APPL PHYSIOL NUTR ME, V40, P641, DOI 10.1139/apnm-2014-0485
   Mahadevan V, 2017, ELIFE, V6, DOI 10.7554/eLife.28270
   Maier T, 2009, FEBS LETT, V583, P3966, DOI 10.1016/j.febslet.2009.10.036
   Malhotra JD, 2007, SEMIN CELL DEV BIOL, V18, P716, DOI 10.1016/j.semcdb.2007.09.003
   Miccoli R, 2008, FUTURE LIPIDOL, V3, P651, DOI 10.2217/17460875.3.6.651
   Mihalik SJ, 2002, J BIOL CHEM, V277, P24771, DOI 10.1074/jbc.M203295200
   Miura Y, 2005, ELECTROPHORESIS, V26, P2786, DOI 10.1002/elps.200500172
   Möller G, 2001, MOL CELL ENDOCRINOL, V171, P61, DOI 10.1016/S0303-7207(00)00388-9
   Nagle CA, 2009, J LIPID RES, V50, pS74, DOI 10.1194/jlr.R800053-JLR200
   Naidoo N, 2009, AGEING RES REV, V8, P150, DOI 10.1016/j.arr.2009.03.001
   Nye C, 2008, TRENDS ENDOCRIN MET, V19, P356, DOI 10.1016/j.tem.2008.08.003
   Park E, 2007, FUTURE LIPIDOL, V2, P503, DOI 10.2217/17460875.2.5.503
   Peng CH, 2011, J AGR FOOD CHEM, V59, P2663, DOI 10.1021/jf1043508
   Polimeni L, 2015, WORLD J HEPATOL, V7, P1325, DOI 10.4254/wjh.v7.i10.1325
   Poudyal H, 2010, BRIT J NUTR, V104, P1322, DOI 10.1017/S0007114510002308
   Reddy JK, 2001, ANNU REV NUTR, V21, P193, DOI 10.1146/annurev.nutr.21.1.193
   Remaley AT, 2001, BIOCHEM BIOPH RES CO, V280, P818, DOI 10.1006/bbrc.2000.4219
   Rodrigo R, 2011, HYPERTENS RES, V34, P431, DOI 10.1038/hr.2010.264
   Rosenow A, 2012, J PROTEOME RES, V11, P4733, DOI 10.1021/pr300539b
   Rubio-Aliaga I., 2014, SYSTEMS BIOL APPROAC, P185
   RUSSELL DW, 1992, CARDIOVASC DRUG THER, V6, P103, DOI 10.1007/BF00054556
   Saleheen D, 2015, LANCET DIABETES ENDO, V3, P507, DOI 10.1016/S2213-8587(15)00126-6
   SELTMAN H, 1985, BIOCHEM J, V230, P19, DOI 10.1042/bj2300019
   Seymour EM, 2009, J MED FOOD, V12, P935, DOI 10.1089/jmf.2008.0270
   Seymour EM, 2008, J MED FOOD, V11, P252, DOI 10.1089/jmf.2007.658
   Soni KG, 2004, J BIOL CHEM, V279, P40683, DOI 10.1074/jbc.M400541200
   Takikawa M, 2010, J NUTR, V140, P527, DOI 10.3945/jn.109.118216
   Tang WH, 2012, FRONT PHARMACOL, V3, DOI 10.3389/fphar.2012.00087
   Tansey JT, 2001, P NATL ACAD SCI USA, V98, P6494, DOI 10.1073/pnas.101042998
   Tsuda T, 2003, J NUTR, V133, P2125, DOI 10.1093/jn/133.7.2125
   Tsuda T, 2004, BIOCHEM BIOPH RES CO, V316, P149, DOI 10.1016/j.bbrc.2004.02.031
   Tulenko TN, 2002, J NUCL CARDIOL, V9, P638, DOI 10.1067/mnc.2002.128959
   Turban S, 2011, FEBS LETT, V585, P269, DOI 10.1016/j.febslet.2010.12.022
   Wang Q, 2009, HEPATOLOGY, V49, P1166, DOI 10.1002/hep.22774
   Wang X, 2017, MOLECULES, V22, DOI 10.3390/molecules22081315
   Xu X, 2004, J BIOL CHEM, V279, P33946, DOI 10.1074/jbc.M404298200
   Zhang H, 2016, J FUNCT FOODS, V22, P363, DOI 10.1016/j.jff.2016.01.004
NR 75
TC 9
Z9 9
U1 1
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2018
VL 10
IS 4
AR 456
DI 10.3390/nu10040456
PG 29
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GJ3HN
UT WOS:000435182900072
PM 29642414
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Stanimirovic, J
   Radovanovic, J
   Banjac, K
   Obradovic, M
   Essack, M
   Zafirovic, S
   Gluvic, Z
   Gojobori, T
   Isenovic, ER
AF Stanimirovic, Julijana
   Radovanovic, Jelena
   Banjac, Katarina
   Obradovic, Milan
   Essack, Magbubah
   Zafirovic, Sonja
   Gluvic, Zoran
   Gojobori, Takashi
   Isenovic, Esma R.
TI Role of C-Reactive Protein in Diabetic Inflammation
SO MEDIATORS OF INFLAMMATION
LA English
DT Review
ID ACUTE-PHASE PROTEINS; INNATE IMMUNE-SYSTEM; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; ADIPOSE-TISSUE; COMPLEMENT ACTIVATION; GUT MICROBIOTA;
   TNF-ALPHA; METABOLIC SYNDROME; OBESE-PATIENTS
AB Even though type 2 diabetes mellitus (T2DM) represents a worldwide chronic health issue that affects about 462 million people, specific underlying determinants of insulin resistance (IR) and impaired insulin secretion are still unknown. There is growing evidence that chronic subclinical inflammation is a triggering factor in the origin of T2DM. Increased C-reactive protein (CRP) levels have been linked to excess body weight since adipocytes produce tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6), which are pivotal factors for CRP stimulation. Furthermore, it is known that hepatocytes produce relatively low rates of CRP in physiological conditions compared to T2DM patients, in which elevated levels of inflammatory markers are reported, including CRP. CRP also participates in endothelial dysfunction, the production of vasodilators, and vascular remodeling, and increased CRP level is closely associated with vascular system pathology and metabolic syndrome. In addition, insulin-based therapies may alter CRP levels in T2DM. Therefore, determining and clarifying the underlying CRP mechanism of T2DM is imperative for novel preventive and diagnostic procedures. Overall, CRP is one of the possible targets for T2DM progression and understanding the connection between insulin and inflammation may be helpful in clinical treatment and prevention approaches.
C1 [Stanimirovic, Julijana; Radovanovic, Jelena; Banjac, Katarina; Obradovic, Milan; Zafirovic, Sonja; Isenovic, Esma R.] Univ Belgrade, VINCA Inst Nucl Sci, Natl Inst Republ Serbia, Dept Radiobiol & Mol Genet, Belgrade, Serbia.
   [Essack, Magbubah; Gojobori, Takashi] King Abdullah Univ Sci & Technol KAUST, Computat Biosci Res Ctr CBRC, Comp Elect & Math Sci & Engn CEMSE Div, Thuwal, Saudi Arabia.
   [Gluvic, Zoran] Univ Belgrade, Univ Clin Hosp Ctr Zemun Belgrade, Clinic Int Med, Sch Med, Belgrade, Serbia.
C3 University of Belgrade; King Abdullah University of Science &
   Technology; University of Belgrade
RP Stanimirovic, J (corresponding author), Univ Belgrade, VINCA Inst Nucl Sci, Natl Inst Republ Serbia, Dept Radiobiol & Mol Genet, Belgrade, Serbia.
EM julijana1008@gmail.com; jelenarad89@gmail.com;
   banjackatarina@hotmail.com; obradovicmilan@hotmail.com;
   magbubah.essack@kaust.edu.sa; sonjazafirovic@hotmail.com;
   zorangluvic@yahoo.com; takashi.gojobori@kaust.edu.sa; isenovic@yahoo.com
RI Radovanović, Jelena/AAD-6068-2021; Isenovic, Esma/D-3017-2009; Gluvic,
   Zoran/Q-5190-2019; Zafirovic, Sonja/HTM-2478-2023; Stanimirovic,
   Julijana/LPQ-7867-2024; Obradovic, Milan/AGN-1229-2022; Essack,
   Magbubah/G-5008-2013
OI Obradovic, Milan/0000-0002-4769-2652; Gluvic, Zoran/0000-0001-6371-6610;
   Radovanovic, Jelena/0000-0002-3005-7943; Zafirovic,
   Sonja/0000-0002-5486-0079; Isenovic, Esma/0000-0002-0012-2636; Banjac,
   Katarina/0000-0001-6100-3887; Essack, Magbubah/0000-0003-2709-5356
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [451-03-9/2021-14/200017]; KAUST grant OSR [4129];
   KAUST Office of Sponsored Research (OSR) Award [FCC/1/1976-20-01]; King
   Abdullah University of Science and Technology (KAUST) Base Research Fund
   [BAS/1/1059-01-01]
FX This work was funded by the Ministry of Education, Science and
   Technological Development of the Republic of Serbia (Contract No.
   #451-03-9/2021-14/200017) and KAUST grant OSR#4129 (awarded to E.R.I.
   and V.B.B.), which also supported M.O. M.E. has been supported by the
   KAUST Office of Sponsored Research (OSR) Award no. FCC/1/1976-20-01, and
   TG by the King Abdullah University of Science and Technology (KAUST)
   Base Research Fund (BAS/1/1059-01-01).
CR Abernethy TJ, 1941, J EXP MED, V73, P173, DOI 10.1084/jem.73.2.173
   Abernethy TJ, 1937, J EXP MED, V65, P59, DOI 10.1084/jem.65.1.59
   Akbari M, 2018, INFLAMMOPHARMACOLOGY, V26, P685, DOI 10.1007/s10787-018-0458-0
   Akbarzadeh M, 2013, IRAN J IMMUNOL, V10, P167, DOI IJIv10i3A5
   Al Bander Z, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17207618
   Ali A, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-85426-9
   Allin KH, 2018, DIABETOLOGIA, V61, P810, DOI 10.1007/s00125-018-4550-1
   Almatroodi SA, 2021, APPL SCI-BASEL, V11, DOI 10.3390/app11073223
   Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
   Amoroso C, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9051234
   Anty R, 2006, AM J GASTROENTEROL, V101, P1824, DOI 10.1111/j.1572-0241.2006.00724.x
   Arnalich F, 2000, HORM METAB RES, V32, P407, DOI 10.1055/s-2007-978662
   Aryan Z, 2018, ANN NUTR METAB, V72, P287, DOI 10.1159/000488537
   Atkinson MA, 2014, LANCET, V383, P69, DOI [10.1016/S0140-6736(13)60591-7, 10.1016/S0140-6736(18)31320-5]
   Badimon L, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.00430
   Bernstein LE, 2006, ARCH INTERN MED, V166, P902, DOI 10.1001/archinte.166.8.902
   Bertelsen M, 2001, DIABETOLOGIA, V44, P605, DOI 10.1007/s001250051667
   Bertoni AG, 2010, DIABETES CARE, V33, P804, DOI 10.2337/dc09-1679
   Boras E, 2014, CYTOKINE, V69, P165, DOI 10.1016/j.cyto.2014.05.027
   Borst SE, 2004, ENDOCRINE, V23, P177, DOI 10.1385/ENDO:23:2-3:177
   Bowker N, 2020, EBIOMEDICINE, V61, DOI 10.1016/j.ebiom.2020.103062
   Burhans MS, 2019, COMPR PHYSIOL, V9, P1, DOI 10.1002/cphy.c170040
   Calabro P, 2005, J AM COLL CARDIOL, V46, P1112, DOI 10.1016/j.jacc.2005.06.017
   Calle MC, 2012, DIABETES METAB, V38, P183, DOI 10.1016/j.diabet.2011.11.006
   Camhi SM, 2010, METABOLISM, V59, P54, DOI 10.1016/j.metabol.2009.07.008
   Chan KC, 2020, FOOD NUTR RES, V64, DOI 10.29219/fnr.v64.4272
   Chandrashekara S., 2014, Int. J. Pharm. Sci. Health Care, V2, pSR3, DOI DOI 10.15305/IJRCI/V2IS1/117
   Chen L, 2012, NAT REV ENDOCRINOL, V8, P228, DOI 10.1038/nrendo.2011.183
   Cho WC, 2006, J CELL BIOCHEM, V99, P256, DOI 10.1002/jcb.20923
   Chung S, 2006, ENDOCRINOLOGY, V147, P5340, DOI 10.1210/en.2006-0536
   Claesson MJ, 2012, NATURE, V488, P178, DOI 10.1038/nature11319
   Creely SJ, 2007, AM J PHYSIOL-ENDOC M, V292, pE740, DOI 10.1152/ajpendo.00302.2006
   Crook M, 2004, DIABETIC MED, V21, P203, DOI 10.1046/j.1464-5491.2003.01030.x
   Dehghan A, 2011, CIRCULATION, V123, P731, DOI 10.1161/CIRCULATIONAHA.110.948570
   Deng YX, 2021, PATHOL ONCOL RES, V27, DOI 10.3389/pore.2021.633480
   Doi Y, 2005, DIABETES CARE, V28, P2497, DOI 10.2337/diacare.28.10.2497
   Dominguez H, 2005, J VASC RES, V42, P517, DOI 10.1159/000088261
   Doupis J, 2009, J CLIN ENDOCR METAB, V94, P2157, DOI 10.1210/jc.2008-2385
   Du Clos Terry W, 2013, ISRN Inflamm, V2013, P379040, DOI 10.1155/2013/379040
   Du Clos TW, 2000, ANN MED, V32, P274, DOI 10.3109/07853890009011772
   Dupuy AM, 2003, CLIN CHEM LAB MED, V41, P948, DOI 10.1515/CCLM.2003.144
   Eisenhardt SU, 2009, CELL CYCLE, V8, P3885, DOI 10.4161/cc.8.23.10068
   Engström G, 2005, DIABETOLOGIA, V48, P2525, DOI 10.1007/s00125-005-0021-6
   Engström G, 2005, DIABETES, V54, P570, DOI 10.2337/diabetes.54.2.570
   Esser N, 2015, ACTA CLIN BELG, V70, P193, DOI 10.1179/2295333715Y.0000000004
   Everett BM, 2018, J AM COLL CARDIOL, V71, P2392, DOI 10.1016/j.jacc.2018.03.002
   Festa A, 2002, DIABETES, V51, P1131, DOI 10.2337/diabetes.51.4.1131
   Festa A, 2000, CIRCULATION, V102, P42, DOI 10.1161/01.CIR.102.1.42
   Fleischman A, 2008, DIABETES CARE, V31, P289, DOI 10.2337/dc07-1338
   Forst T, 2008, ATHEROSCLEROSIS, V197, P311, DOI 10.1016/j.atherosclerosis.2007.05.006
   Freeman DJ, 2002, DIABETES, V51, P1596, DOI 10.2337/diabetes.51.5.1596
   Fu CC, 2009, ACTA DIABETOL, V46, P127, DOI 10.1007/s00592-008-0069-0
   Fujimoto W.Y., 2000, AM J MED, V108, p9S, DOI DOI 10.1016/S0002-9343(00)00337-5
   Gabay C, 1999, NEW ENGL J MED, V340, P448, DOI 10.1056/NEJM199902113400607
   Gasecka A, 2020, J CLIN MED, V9, DOI 10.3390/jcm9092807
   Ghanim H, 2009, DIABETES CARE, V32, P2281, DOI 10.2337/dc09-0979
   Gharib HM, 2020, HELIYON, V6, DOI 10.1016/j.heliyon.2020.e03812
   Goldberg I, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000022551
   GOLDBERGER G, 1987, J IMMUNOL, V138, P3967
   Goldfine AB, 2008, CTS-CLIN TRANSL SCI, V1, P36, DOI 10.1111/j.1752-8062.2008.00026.x
   Goldman JL, 2014, PULM CIRC, V4, P280, DOI 10.1086/675991
   Gómez-Ambrosi J, 2002, CLIN BIOCHEM, V35, P315, DOI 10.1016/S0009-9120(02)00320-X
   Gopaul NK, 2001, DIABETOLOGIA, V44, P706, DOI 10.1007/s001250051679
   Guo L, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194631
   Han TS, 2002, DIABETES CARE, V25, P2016, DOI 10.2337/diacare.25.11.2016
   Hanefeld M, 2007, J AM COLL CARDIOL, V49, P290, DOI 10.1016/j.jacc.2006.08.054
   Hayashino Y, 2014, DIABETES CARE, V37, P2947, DOI 10.2337/dc14-1357
   Hensen J, 2013, DIABETES METAB, V39, P524, DOI 10.1016/j.diabet.2013.07.003
   Ige Abayomi Oluwatosin, 2018, Journal of Basic and Clinical Physiology and Pharmacology, V29, P507, DOI 10.1515/jbcpp-2017-0104
   Iikuni Noriko, 2008, Current Immunology Reviews, V4, P70, DOI 10.2174/157339508784325046
   Jain S, 2011, J PHARM BIOALLIED SC, V3, P118, DOI 10.4103/0975-7406.76489
   Ji SR, 2007, FASEB J, V21, P284, DOI 10.1096/fj.06-6722com
   Kaneko H, 2011, CARDIOVASC RES, V91, P546, DOI 10.1093/cvr/cvr088
   Kanmani S, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-40987-8
   KAPLAN MH, 1974, J IMMUNOL, V112, P2135
   Kato K, 2021, EXP CLIN ENDOCR DIAB, V129, P289, DOI 10.1055/a-0869-7584
   Kato K, 2019, CAN J DIABETES, V43, P40, DOI 10.1016/j.jcjd.2018.03.007
   Khreiss T, 2004, CIRCULATION, V110, P2713, DOI 10.1161/01.CIR.0000146846.00816.DD
   KILPATRICK JM, 1991, IMMUNOL RES, V10, P43, DOI 10.1007/BF02918166
   Kishimoto T, 2006, ARTHRITIS RES THER, V8, DOI 10.1186/ar1916
   Klover PJ, 2004, INT J BIOCHEM CELL B, V36, P753, DOI 10.1016/j.biocel.2003.10.002
   Knüpfer H, 2007, BREAST CANCER RES TR, V102, P129, DOI 10.1007/s10549-006-9328-3
   Koh A, 2020, CELL METAB, V32, P643, DOI 10.1016/j.cmet.2020.07.012
   Koh A, 2018, CELL, V175, P947, DOI 10.1016/j.cell.2018.09.055
   Krogh-Madsen R, 2006, AM J PHYSIOL-ENDOC M, V291, pE108, DOI 10.1152/ajpendo.00471.2005
   Kurauti MA, 2017, SCI REP-UK, V7, DOI 10.1038/srep46750
   Lainampetch J, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/9051929
   Larsen CM, 2007, NEW ENGL J MED, V356, P1517, DOI 10.1056/NEJMoa065213
   Larsen CM, 2009, DIABETES CARE, V32, P1663, DOI 10.2337/dc09-0533
   Lee CC, 2009, DIABETOLOGIA, V52, P1040, DOI 10.1007/s00125-009-1338-3
   Li J, 2020, EUR REV MED PHARMACO, V24, P10162, DOI 10.26355/eurrev_202010_23236
   Lim LS, 2010, INVEST OPHTH VIS SCI, V51, P4458, DOI 10.1167/iovs.09-4939
   Liu Q, 2015, EUR REV MED PHARMACO, V19, P4558
   Lontchi-Yimagou E, 2013, CURR DIABETES REP, V13, P435, DOI 10.1007/s11892-013-0375-y
   Lv YB, 2017, J NANOBIOTECHNOL, V15, DOI 10.1186/s12951-017-0267-4
   Ma YC, 2020, RSC ADV, V10, P9723, DOI 10.1039/c9ra10386d
   Marnell L, 2005, CLIN IMMUNOL, V117, P104, DOI 10.1016/j.clim.2005.08.004
   Marques-Vidal P, 2013, CLIN ENDOCRINOL, V78, P232, DOI 10.1111/j.1365-2265.2012.04384.x
   Mauer J, 2014, NAT IMMUNOL, V15, P423, DOI 10.1038/ni.2865
   Mohallem R, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-77914-1
   Mold C, 1999, IMMUNOPHARMACOLOGY, V42, P23, DOI 10.1016/S0162-3109(99)00007-7
   Molinaro A, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-19589-w
   Morioka K, 2021, TALANTA, V224, DOI 10.1016/j.talanta.2020.121725
   Mtintsilana A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061246
   Mugabo Y, 2010, CURR DIABETES REV, V6, P27, DOI 10.2174/157339910790442628
   Nakanishi S, 2003, DIABETES CARE, V26, P2754, DOI 10.2337/diacare.26.10.2754
   Naveen Nishal G., 2022, Asian Journal of Medical Sciences, V13, P51, DOI 10.3126/ajms.v13i4.41460
   Nehring S.M., 2020, C Reactive Protein (CRP)
   Nehring SM., 2022, StatPearls
   Nisar M, 2021, PAK J PHARM SCI, V34, P1217, DOI 10.36721/PJPS.2021.34.3.SP.1217-1225.1
   Nishikawa T, 2000, NATURE, V404, P787, DOI 10.1038/35008121
   Obasi DC, 2021, BIOCHEM BIOPHYS REP, V27, DOI 10.1016/j.bbrep.2021.101057
   Obradovic M., 2020, OBESITY DIABETES SCI, P705, DOI 10.1007/978-3-030-53370-0_52
   Obradovic M, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.585887
   Obradovic M, 2015, ANGIOLOGY, V66, P25, DOI 10.1177/0003319713514477
   Obradovic MM, 2015, CLIN CHEM LAB MED, V53, P29, DOI 10.1515/cclm-2014-0590
   Oguntibeju Oluwafemi Omoniyi, 2019, Int J Physiol Pathophysiol Pharmacol, V11, P45
   Ouchi N, 2003, CIRCULATION, V107, P671, DOI 10.1161/01.CIR.0000055188.83694.B3
   Ouchi N, 2007, CLIN CHIM ACTA, V380, P24, DOI 10.1016/j.cca.2007.01.026
   Papanas N, 2011, ANGIOLOGY, V62, P291, DOI 10.1177/0003319710394164
   Park JS, 2010, ACTA DIABETOL, V47, P113, DOI 10.1007/s00592-009-0125-4
   Pathak A, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.00943
   PEPYS MB, 1983, ADV IMMUNOL, V34, P141, DOI 10.1016/S0065-2776(08)60379-X
   Pfützner A, 2005, J AM COLL CARDIOL, V45, P1925, DOI 10.1016/j.jacc.2005.03.041
   Pickup JC, 1998, DIABETOLOGIA, V41, P1241, DOI 10.1007/s001250051058
   Pires-Neto OD, 2020, INFECT GENET EVOL, V80, DOI 10.1016/j.meegid.2020.104200
   Plomgaard P, 2005, DIABETES, V54, P2939, DOI 10.2337/diabetes.54.10.2939
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
   Pulgaron ER, 2014, CURR DIABETES REP, V14, DOI 10.1007/s11892-014-0508-y
   Qiu FF, 2020, CLIN SCI, V134, P1613, DOI 10.1042/CS20200085
   Ramalingam L, 2017, BBA-MOL BASIS DIS, V1863, P1106, DOI 10.1016/j.bbadis.2016.07.019
   Rao G, 2001, AM FAM PHYSICIAN, V63, P1159
   Rask-Madsen C, 2003, CIRCULATION, V108, P1815, DOI 10.1161/01.CIR.0000091406.72832.11
   Rhodes B, 2011, NAT REV RHEUMATOL, V7, P283, DOI 10.1038/nrrheum.2011.37
   Ridker PM, 2012, CIRCULATION, V126, P2739, DOI 10.1161/CIRCULATIONAHA.112.122556
   Roglic G, 2016, Global report on psoriasis
   Rohleder N, 2012, ANN NY ACAD SCI, V1261, P88, DOI 10.1111/j.1749-6632.2012.06634.x
   Russo GT, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0109702
   Ryu J, 2007, CARDIOVASC RES, V75, P555, DOI 10.1016/j.cardiores.2007.04.027
   Sardesai AU, 2020, MICROMACHINES-BASEL, V11, DOI 10.3390/mi11030333
   Satoh N, 2003, DIABETES CARE, V26, P2493, DOI 10.2337/diacare.26.9.2493
   Sayit AT, 2021, REV INST MED TROP SP, V63, DOI [10.1590/S1678-9946202163051, 10.1590/s1678-9946202163051]
   Scheithauer TPM, 2020, FRONT IMMUNOL, V11, DOI 10.3389/fimmu.2020.571731
   Schmidt-Arras D, 2016, J HEPATOL, V64, P1403, DOI 10.1016/j.jhep.2016.02.004
   Sedigheh A, 2011, AFR J PHARM PHARMACO, V5, P2620, DOI 10.5897/AJPP11.635
   Shamsuzzaman ASM, 2004, CIRCULATION, V109, P2181, DOI 10.1161/01.CIR.0000127960.28627.75
   Shim K, 2020, WORLD J DIABETES, V11, P1, DOI 10.4239/wjd.v11.i1.1
   SHINE B, 1981, CLIN CHIM ACTA, V117, P13, DOI 10.1016/0009-8981(81)90005-X
   Shirpoor Alireza, 2015, Iranian Biomedical Journal, V19, P117, DOI 10.6091/ibj.1449.2015
   Shrivastava AK, 2015, EGYPT HEART J, V67, P89, DOI 10.1016/j.ehj.2014.11.005
   Shrive AK, 1996, NAT STRUCT BIOL, V3, P346, DOI 10.1038/nsb0496-346
   Siddiqui MF, 2020, NANOMATERIALS-BASEL, V10, DOI 10.3390/nano10061240
   Sisman AR, 2007, J CLIN LAB ANAL, V21, P71, DOI 10.1002/jcla.20141
   Slevin M, 2015, SCI REP-UK, V5, DOI 10.1038/srep13281
   Sloan-Lancaster J, 2013, DIABETES CARE, V36, P2239, DOI 10.2337/dc12-1835
   Socha MW, 2021, CRIT REV ONCOL HEMAT, V164, DOI 10.1016/j.critrevonc.2021.103419
   Song J, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0144406
   Sproston NR, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.00754
   Sudhakar M, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01167
   Suman RK, 2016, ADV PHARMACOL SCI, V2016, DOI 10.1155/2016/9463476
   Szkudelski T, 2001, PHYSIOL RES, V50, P537
   Tabassum R, 2017, Mymensingh Med J, V26, P56
   Talebi-Garakani E, 2013, ENDOCRINE, V43, P564, DOI 10.1007/s12020-012-9786-9
   Tang PMK, 2021, MOL THER, V29, P365, DOI 10.1016/j.ymthe.2020.08.017
   Thiele JR, 2014, CIRCULATION, V130, P35, DOI 10.1161/CIRCULATIONAHA.113.007124
   Thompson D, 1999, STRUCTURE, V7, P169, DOI 10.1016/S0969-2126(99)80023-9
   Thorand B, 2003, ARCH INTERN MED, V163, P93, DOI 10.1001/archinte.163.1.93
   Thorand B, 2007, DIABETES CARE, V30, P854, DOI 10.2337/dc06-1693
   Tian T, 2021, BMC EMERG MED, V21, DOI 10.1186/s12873-021-00477-5
   TILLETT WILLIAM S., 1930, JOUR EXP MED, V52, P561, DOI 10.1084/jem.52.4.561
   Trayhurn P, 2005, ENDOCRINOLOGY, V146, P1003, DOI 10.1210/en.2004-1597
   Trpkovic A., 2016, ENCY SIGNALING MOL, P1
   Trpkovic A, 2015, CURR PHARM ANAL, V11, P60
   Tsalamandris S, 2019, EUR CARDIOL REV, V14, P50, DOI 10.15420/ecr.2018.33.1
   Turu MM, 2008, BMC CELL BIOL, V9, DOI 10.1186/1471-2121-9-47
   Uemura H, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0178672
   van den Munckhof ICL, 2018, OBES REV, V19, P1719, DOI 10.1111/obr.12750
   van Dielen FMH, 2001, INT J OBESITY, V25, P1759, DOI 10.1038/sj.ijo.0801825
   van Woudenbergh GJ, 2011, J NUTR METAB, V2011, DOI 10.1155/2011/623076
   Vanderschueren S, 2006, EUR J INTERN MED, V17, P430, DOI 10.1016/j.ejim.2006.02.025
   Varma Vandana, 2016, J Lab Physicians, V8, P25, DOI 10.4103/0974-2727.176230
   Vinagre I, 2014, CARDIOVASC DIABETOL, V13, DOI 10.1186/1475-2840-13-34
   VOLANAKIS JE, 1982, ANN NY ACAD SCI, V389, P235, DOI 10.1111/j.1749-6632.1982.tb22140.x
   Wang X, 2013, DIABETES CARE, V36, P166, DOI 10.2337/dc12-0702
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
   Wellen KE, 2003, J CLIN INVEST, V112, P1785, DOI 10.1172/JCI20514
   Wlazlo N, 2014, DIABETES CARE, V37, P1900, DOI 10.2337/dc13-2804
   Wu H, 2020, CELL METAB, V32, P379, DOI 10.1016/j.cmet.2020.06.011
   Wu TL, 2002, CLIN CHIM ACTA, V322, P163, DOI 10.1016/S0009-8981(02)00172-9
   Wu Y, 2015, BIOL CHEM, V396, P1181, DOI 10.1515/hsz-2015-0149
   Yachnyk I.M., 2015, GALICIAN MED J, V22, P53
   Yanagawa T, 2007, DIABETES RES CLIN PR, V75, P2, DOI 10.1016/j.diabres.2006.04.019
   Yang ML, 2021, DIABETOLOGIA, V64, P1169, DOI 10.1007/s00125-021-05384-9
   Yusuf BO, 2021, J TRADIT COMPL MED, V11, P336, DOI 10.1016/j.jtcme.2021.01.005
   Zhang GL, 2020, PAK J MED SCI, V36, P1382, DOI 10.12669/pjms.36.6.2088
   Zhang HH, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/2494057
   Zheng ZC, 2019, J FOOD SCI, V84, P1194, DOI 10.1111/1750-3841.14505
   Zhou HT, 2020, BMC CARDIOVASC DISOR, V20, DOI 10.1186/s12872-020-01704-w
   Zou XL, 2012, ASIAN BIOMED, V6, P903, DOI 10.5372/1905-7415.0605.137
NR 199
TC 71
Z9 76
U1 0
U2 16
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PD MAY 17
PY 2022
VL 2022
AR 3706508
DI 10.1155/2022/3706508
PG 15
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA 1U0RG
UT WOS:000805127700001
PM 35620114
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zugravu, CA
   Bohiltea, RE
   Salmen, T
   Pogurschi, E
   Otelea, MR
AF Zugravu, Corina-Aurelia
   Bohiltea, Roxana-Elena
   Salmen, Teodor
   Pogurschi, Elena
   Otelea, Marina Ruxandra
TI Antioxidants in Hops: Bioavailability, Health Effects and Perspectives
   for New Products
SO ANTIOXIDANTS
LA English
DT Review
DE hops; antioxidants; metabolic syndrome; bioavailability
ID HUMULUS-LUPULUS L.; OXIDATIVE STRESS; PRENYLATED FLAVONOIDS;
   LUNG-CANCER; PPAR-ALPHA; BEER HOPS; IN-VITRO; XANTHOHUMOL; EXTRACT;
   GLUCOSE
AB Hop plant (Humulus lupulus L.) has been used by humans for ages, presumably first as a herbal remedy, then in the manufacturing of different products, from which beer is the most largely consumed. Female hops cones have different useful chemical compounds, an important class being antioxidants, mainly polyphenols. This narrative review describes the main antioxidants in hops, their bioavailability and biological effects, and the results obtained by now in the primary and secondary prevention of several non-communicable diseases, such as the metabolic syndrome related diseases and oncology. This article presents in vitro and in vivo data in order to better understand what was accomplished in terms of knowledge and practice, and what needs to be clarified by additional studies, mainly regarding xantohumol and its derivates, as well as regarding the bitter acids of hops. The multiple protective effects found by different studies are hindered up to now by the low bioavailability of some of the main antioxidants in hops. However, there are new promising products with important health effects and perspectives of use as food supplements, in a market where consumers increasingly search for products originating directly from plants.
C1 [Zugravu, Corina-Aurelia] Carol Davila Univ Med & Pharm, Dept Hyg & Ecol, Bucharest 050463, Romania.
   [Bohiltea, Roxana-Elena] Carol Davila Univ Med & Pharm Bucharest, Dept Obstet & Gynecol, Bucharest 020021, Romania.
   [Salmen, Teodor] Prof Dr NC Paulescu Natl Inst Diabet, Dept Diabet Nutr & Metab Dis, Bucharest 030167, Romania.
   [Pogurschi, Elena] Univ Agron Sci & Vet Med Bucharest, Fac Anim Prod Engn & Management, 57 Marasti Blvd, Bucharest 011464, Romania.
   [Otelea, Marina Ruxandra] Carol Davila Univ Med & Pharm, Clin Dept 5, Bucharest 050463, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy; University of Agronomic Science & Veterinary
   Medicine - Bucharest; Carol Davila University of Medicine & Pharmacy
RP Salmen, T (corresponding author), Prof Dr NC Paulescu Natl Inst Diabet, Dept Diabet Nutr & Metab Dis, Bucharest 030167, Romania.
EM corina.zugravu@umfcd.ro; roxana.bohiltea@umfcd.ro;
   teodor.salmen@gmail.com; elena.pogurschi@usamv.ro;
   marina.otelea@umfcd.ro
RI Otelea, Marina/N-4200-2016; Salmen, Teodor/ABG-2747-2021; Zugravu,
   Corina/AAX-3256-2020; Bohiltea, Roxana Elena/L-6144-2017; SALMEN,
   Teodor/ACM-9451-2022
OI Zugravu, Corina/0000-0002-3563-6987; Bohiltea, Roxana
   Elena/0000-0002-6381-7419; Otelea, Marina Ruxandra/0000-0002-0829-0562;
   SALMEN, Teodor/0000-0003-4548-7441
CR Afzal S, 2012, CANCER CHEMOTH PHARM, V69, P301, DOI 10.1007/s00280-011-1700-2
   Almeida AD, 2020, INT J FOOD SCI TECH, V55, P340, DOI 10.1111/ijfs.14311
   Ambroz M, 2019, NUTRIENTS, V11, DOI 10.3390/nu11040879
   Arczewska M, 2013, BBA-BIOMEMBRANES, V1828, P213, DOI 10.1016/j.bbamem.2012.10.009
   Astray G, 2020, APPL SCI-BASEL, V10, DOI 10.3390/app10155074
   Avula B, 2004, J CHROMATOGR SCI, V42, P378, DOI 10.1093/chromsci/42.7.378
   Bolton JL, 2019, CHEM RES TOXICOL, V32, P222, DOI 10.1021/acs.chemrestox.8b00345
   Bouayed J, 2010, OXID MED CELL LONGEV, V3, P228, DOI 10.4161/oxim.3.4.12858
   Bouly M, 2001, J BIOL CHEM, V276, P25841, DOI 10.1074/jbc.M101160200
   Brites F, 2017, BBA CLIN, V8, P66, DOI 10.1016/j.bbacli.2017.07.002
   Butler LM, 2015, AM J EPIDEMIOL, V181, P397, DOI 10.1093/aje/kwu304
   Cattoor K, 2011, FOOD FUNCT, V2, P412, DOI 10.1039/c1fo10009b
   Cattoor K, 2010, J AGR FOOD CHEM, V58, P4132, DOI 10.1021/jf904079h
   Ciriminna R, 2018, LWT-FOOD SCI TECHNOL, V91, P160, DOI 10.1016/j.lwt.2018.01.037
   Contreras AV, 2013, ADV NUTR, V4, P439, DOI 10.3945/an.113.003798
   Costa R, 2013, J NAT PROD, V76, P2047, DOI 10.1021/np4002898
   de Vries MA, 2014, ADV EXP MED BIOL, V824, P161, DOI 10.1007/978-3-319-07320-0_12
   Dimpfel W, 2008, EUR J MED RES, V13, P200
   Domínguez R, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8100429
   Dupré-Crochet S, 2013, J LEUKOCYTE BIOL, V94, P657, DOI 10.1189/jlb.1012544
   Fernandes RPP, 2018, MEAT SCI, V137, P244, DOI 10.1016/j.meatsci.2017.11.018
   Festa M, 2011, J NAT PROD, V74, P2505, DOI 10.1021/np200390x
   Forino M, 2016, J NAT PROD, V79, P590, DOI 10.1021/acs.jnatprod.5b01052
   Fouani L, 2019, ANTIOXID REDOX SIGN, V30, P1096, DOI 10.1089/ars.2017.7387
   Gerloff A, 2010, INT J ENV RES PUB HE, V7, P1093, DOI 10.3390/ijerph7031093
   Girisa S, 2021, IUBMB LIFE, V73, P1016, DOI 10.1002/iub.2522
   Rosso LG, 2017, BBA-MOL CELL BIOL L, V1862, P188, DOI 10.1016/j.bbalip.2016.10.014
   Goodman GE, 2004, J NATL CANCER I, V96, P1743, DOI 10.1093/jnci/djh320
   Harish V, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22094478
   Hennessy M, HOPS FERNET NEXT SRI
   Horton JD, 2002, J CLIN INVEST, V109, P1125, DOI 10.1172/JCI200215593
   Alonso-Esteban JI, 2019, IND CROP PROD, V134, P154, DOI 10.1016/j.indcrop.2019.04.001
   Inui T, 2017, FOOD CHEM, V225, P69, DOI 10.1016/j.foodchem.2017.01.002
   Jelínek L, 2014, J I BREWING, V120, P99, DOI 10.1002/jib.126
   Jiang CH, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00530
   Karabín M, 2016, COMPR REV FOOD SCI F, V15, P542, DOI 10.1111/1541-4337.12201
   Karabin M, 2015, BIOTECHNOL ADV, V33, P1063, DOI 10.1016/j.biotechadv.2015.02.009
   Kersten S, 2008, PPAR RES, V2008, DOI 10.1155/2008/132960
   Khatib N, 2020, J FOOD SCI TECH MYS, V57, P2629, DOI 10.1007/s13197-020-04299-4
   Kirkwood JS, 2013, J BIOL CHEM, V288, P19000, DOI 10.1074/jbc.M112.445452
   Kobus-Cisowska J, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061377
   Koetter U., 2010, HerbalGram, V87, P44
   Kolovou GD, 2005, POSTGRAD MED J, V81, P358, DOI 10.1136/pgmj.2004.025601
   Kowalczyk D, 2016, FOOD HYDROCOLLOID, V60, P384, DOI 10.1016/j.foodhyd.2016.04.010
   Krofta K, 2008, J I BREWING, V114, P160, DOI 10.1002/j.2050-0416.2008.tb00321.x
   Lamy V, 2008, APOPTOSIS, V13, P1232, DOI 10.1007/s10495-008-0250-5
   Lamy V, 2011, ONCOL REP, V26, P109, DOI 10.3892/or.2011.1273
   Le N-A., 2020, APOLIPOPROTEINS TRIG, DOI DOI 10.5772/INTECHOPEN.91303
   Legette L, 2014, MOL NUTR FOOD RES, V58, P248, DOI 10.1002/mnfr.201300333
   Legette L, 2012, MOL NUTR FOOD RES, V56, P466, DOI 10.1002/mnfr.201100554
   Legette LL, 2013, PHYTOCHEMISTRY, V91, P236, DOI 10.1016/j.phytochem.2012.04.018
   Liu M, 2017, MOLECULES, V22, DOI 10.3390/molecules22010036
   Liu M, 2014, J AGR FOOD CHEM, V62, P5548, DOI 10.1021/jf500426z
   Liu YM, 2007, J AM SOC BREW CHEM, V65, P116, DOI 10.1094/ASBCJ-2007-0211-01
   Lnenicková K, 2020, NUTRIENTS, V12, DOI 10.3390/nu12072138
   Macchioni V, 2022, PLANTS-BASEL, V11, DOI 10.3390/plants11010099
   Manna P, 2015, METAB SYNDR RELAT D, V13, P423, DOI 10.1089/met.2015.0095
   Mashkour M, 2013, MINERVA BIOTECNOL, V25, P171
   Miura Y, 2005, BRIT J NUTR, V93, P559, DOI 10.1079/BJN20041384
   Mukai R, 2018, BIOSCI BIOTECH BIOCH, V82, P207, DOI 10.1080/09168451.2017.1415750
   Muzykiewicz Anna, 2019, Herba Polonica, V65, P1, DOI 10.2478/hepo-2019-0013
   Nikmaram N, 2018, MEAT SCI, V145, P245, DOI 10.1016/j.meatsci.2018.06.031
   Nikolic D, 2013, CURR ANAL CHEM, V9, P71, DOI 10.2174/157341113804486554
   Nionelli L, 2018, INT J FOOD MICROBIOL, V266, P173, DOI 10.1016/j.ijfoodmicro.2017.12.002
   Nookandeh A, 2004, PHYTOCHEMISTRY, V65, P561, DOI 10.1016/j.phytochem.2003.11.016
   Nowak B, 2020, ADV CLIN EXP MED, V29, P1101, DOI 10.17219/acem/126293
   Nozawa H, 2005, BIOCHEM BIOPH RES CO, V336, P754, DOI 10.1016/j.bbrc.2005.08.159
   Obara K, 2009, CLIN NUTR, V28, P278, DOI 10.1016/j.clnu.2009.03.012
   Pan L, 2020, BMC IMMUNOL, V21, DOI 10.1186/s12865-020-0335-7
   Pang Y, 2007, MOL NUTR FOOD RES, V51, P872, DOI 10.1002/mnfr.200600252
   Paraiso IL, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.643857
   Paraiso IL, 2019, MOL NUTR FOOD RES, V63, DOI 10.1002/mnfr.201800923
   Piconi L, 2006, DIABETES-METAB RES, V22, P198, DOI 10.1002/dmrr.613
   Pinto C, 2012, FOOD CHEM TOXICOL, V50, P3405, DOI 10.1016/j.fct.2012.07.035
   Polvani S, 2012, PPAR RES, V2012, DOI 10.1155/2012/641087
   Poplonski J, 2018, MOLECULES, V23, DOI 10.3390/molecules23040776
   Possemiers S, 2005, J AGR FOOD CHEM, V53, P6281, DOI 10.1021/jf0509714
   Possemiers S, 2006, J NUTR, V136, P1862, DOI 10.1093/jn/136.7.1862
   Prado Carla M, 2011, ISRN Allergy, V2011, P832560, DOI 10.5402/2011/832560
   Protsenko L, 2018, UKR FOOD J, V7, P65, DOI [10.24263/2304-974X-2018-7-1-7, 10.24263/2304-974x-2018-7-1-7]
   Roehrer S, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0213469
   Roehrer S, 2018, J CHROMATOGR B, V1095, P39, DOI 10.1016/j.jchromb.2018.07.018
   Scagliarini A, 2020, CELLS-BASEL, V9, DOI 10.3390/cells9040932
   Seliger JM, 2018, J ENZYM INHIB MED CH, V33, P607, DOI 10.1080/14756366.2018.1437728
   Slawinska-Brych A, 2021, CELLS-BASEL, V10, DOI 10.3390/cells10061484
   Slawinska-Brych A, 2015, CHEM-BIOL INTERACT, V240, P110, DOI 10.1016/j.cbi.2015.08.008
   Sosa V, 2013, AGEING RES REV, V12, P376, DOI 10.1016/j.arr.2012.10.004
   Steenackers B, 2015, FOOD CHEM, V172, P742, DOI 10.1016/j.foodchem.2014.09.139
   Stevens JF, 2004, PHYTOCHEMISTRY, V65, P1317, DOI 10.1016/j.phytochem.2004.04.025
   Stevens JF, 2003, CHEM RES TOXICOL, V16, P1277, DOI 10.1021/tx020100d
   Stevens JF, 2000, PHYTOCHEMISTRY, V53, P759, DOI 10.1016/S0031-9422(00)00005-4
   Takahashi K, 2017, J OLEO SCI, V66, P531, DOI 10.5650/jos.ess16234
   Tedesco I, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10010029
   Vanhoecke BW, 2005, IN VIVO, V19, P103
   Venturelli S, 2016, NUTRITION, V32, P1171, DOI 10.1016/j.nut.2016.03.020
   Verzele M., 1957, Bull. Soc. Chim. Belg, V66, P452, DOI [DOI 10.1002/BSCB, 10.1002/bscb.19570660137, DOI 10.1002/BSCB.19570660137]
   Villalobos-Delgado LH, 2015, SMALL RUMINANT RES, V125, P73, DOI 10.1016/j.smallrumres.2015.02.008
   Wei SS, 2018, ONCOL REP, V40, P3213, DOI 10.3892/or.2018.6723
   Wesolowska O, 2014, BBA-BIOMEMBRANES, V1838, P173, DOI 10.1016/j.bbamem.2013.09.009
   Wietstock P, 2010, J I BREWING, V116, P157, DOI 10.1002/j.2050-0416.2010.tb00412.x
   Wunderlich S, 2005, MOL NUTR FOOD RES, V49, P874, DOI 10.1002/mnfr.200500051
   Yajima H, 2005, INT J OBESITY, V29, P991, DOI 10.1038/sj.ijo.0802965
   YASUKAWA K, 1995, ONCOLOGY, V52, P156
   Yong WK, 2015, PHARMACOGN MAG, V11, pS275, DOI 10.4103/0973-1296.166069
   Yui K, 2014, J OLEO SCI, V63, P159, DOI 10.5650/jos.ess13136
   Zanoli P, 2008, J ETHNOPHARMACOL, V116, P383, DOI 10.1016/j.jep.2008.01.011
   Zhang B, 2015, FREE RADICAL BIO MED, V89, P486, DOI 10.1016/j.freeradbiomed.2015.09.021
   Zhang Y, 2021, ELIFE, V10, DOI 10.7554/eLife.66398
NR 108
TC 26
Z9 26
U1 1
U2 37
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD FEB
PY 2022
VL 11
IS 2
AR 241
DI 10.3390/antiox11020241
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA ZL7DS
UT WOS:000763834600001
PM 35204124
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mari, A
   Abufaraj, M
   Mansy, K
   Sievert, KD
AF Mari, Andrea
   Abufaraj, Mohammad
   Mansy, Karim
   Sievert, Karl-Dietrich
TI Obesity and its implications on nononcological urological surgery
SO CURRENT OPINION IN UROLOGY
LA English
DT Review
DE incontinence; metabolic syndrome; nononcological urological surgery;
   obesity; outcomes and complications; urolithiasis
ID BODY-MASS INDEX; BENIGN PROSTATIC ENLARGEMENT; MIDURETHRAL SLING
   PROCEDURES; STRESS URINARY-INCONTINENCE; MID-URETHRAL SLINGS; LONG-TERM
   OUTCOMES; PERCUTANEOUS NEPHROLITHOTOMY; FLEXIBLE URETERORENOSCOPY;
   METABOLIC SYNDROME; RENAL STONES
AB Purpose of review
   To review and summarize the current literature of the implications of obesity on nononcological urological surgery. We conducted a comprehensive search of the current literature with emphasis on the published literature in the last 18 months.
   Recent findings
   Over time, obese patients have become a more common encounter in clinical practice. Obesity represents a considerable operative challenge and has been linked to a higher rate of postoperative complications. Data regarding surgery for incontinence are inconsistent. Nevertheless, the success rates in obese women are high, and complication rates are relatively low with comparable results to nonobese women. In renal surgery, percutaneous nephrolithotomy and minipercutaneous nephrolithotomy are feasible, well tolerated, and effective even in obese patients. However, certain precautions and availability of proper instruments are necessary.
   Summary
   Although randomized clinical data are lacking and the results of many studies are inconsistent, evidence supports the feasibility and safety of different nononcological urological interventions in obese patients. Moreover, the success rates and the overall complication rates seem to be comparable to nonobese patients with some exceptions.
C1 [Mari, Andrea; Abufaraj, Mohammad; Mansy, Karim; Sievert, Karl-Dietrich] Med Univ Vienna, Dept Urol, Vienna, Austria.
   [Abufaraj, Mohammad] Univ Jordan, Jordan Univ Hosp, Dept Special Surg, Div Urol, Amman, Jordan.
   [Sievert, Karl-Dietrich] Univ Med Ctr, Dept Urol, Rostock, Germany.
C3 Medical University of Vienna; University of Jordan; University of
   Rostock
RP Sievert, KD (corresponding author), Med Univ Vienna, Vienna Gen Hosp, Dept Urol, Wahringer Gurtel 18-20, A-1090 Vienna, Austria.
EM kd_sievert@hotmail.com
RI Mari, Andrea/N-7656-2019; Abufaraj, Mohammad/I-2336-2019; Mari,
   Andrea/H-8616-2017
OI Mari, Andrea/0000-0001-9070-5706; Abufaraj, Mohammad/0000-0002-6603-6319
CR Abdul-Muhsin H, 2014, BJU INT, V113, P84, DOI 10.1111/j.1464-410X.2013.11798.x
   Akbulut F, 2016, SPRINGERPLUS, V5, DOI 10.1186/s40064-016-2830-0
   Alkan E, 2015, UROLITHIASIS, V43, P243, DOI 10.1007/s00240-015-0750-z
   Barber MD, 2008, OBSTET GYNECOL, V111, P611, DOI 10.1097/AOG.0b013e318162f22e
   Bauer RM, 2011, EUR UROL, V59, P985, DOI 10.1016/j.eururo.2011.03.020
   Brennand EA, 2015, BJOG-INT J OBSTET GY, V122, P1705, DOI 10.1111/1471-0528.13132
   Bullock TL, 2006, BJU INT, V98, P32, DOI 10.1111/j.1464-410X.2006.06361.x
   Cakmak O, 2016, CUAJ-CAN UROL ASSOC, V10, pE99, DOI 10.5489/cuaj.3484
   Chapple CR, 2017, EUR UROL
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Dindo D, 2003, LANCET, V361, P2032, DOI 10.1016/S0140-6736(03)13640-9
   Doizi S, 2015, UROLOGY, V85, P38, DOI 10.1016/j.urology.2014.08.028
   Eckel RH, 2005, LANCET, V365, P1415, DOI 10.1016/S0140-6736(05)66378-7
   El-Assmy AM, 2007, EUR UROL, V52, P199, DOI 10.1016/j.eururo.2006.11.049
   Fuller A, 2012, J UROLOGY, V188, P138, DOI 10.1016/j.juro.2012.03.013
   Gacci M, 2015, BJU INT, V116, P271, DOI 10.1111/bju.13038
   Gacci M, 2015, BJU INT, V115, P24, DOI 10.1111/bju.12728
   Gore JL, 2006, AM J TRANSPLANT, V6, P357, DOI 10.1111/j.1600-6143.2005.01198.x
   Haverkorn RM, 2011, J UROLOGY, V185, P987, DOI 10.1016/j.juro.2010.10.064
   Hill CJ, 2015, NEPHROL DIAL TRANSPL, V30, P1403, DOI 10.1093/ndt/gfv214
   Hwang IS, 2012, KOREAN J UROL, V53, P171, DOI 10.4111/kju.2012.53.3.171
   Ishii H, 2016, J ENDOUROL, V30, P135, DOI 10.1089/end.2015.0547
   Jeong SJ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0113517
   Karaman U, 2016, NEUROUROL URODYN
   Kassi E, 2011, BMC MED, V9, DOI 10.1186/1741-7015-9-48
   Keheila M, 2016, BJU INT, V117, P300, DOI 10.1111/bju.13155
   Kelly T, 2008, INT J OBESITY, V32, P1431, DOI 10.1038/ijo.2008.102
   Khullar V, 2014, NEUROUROL URODYNAM, V33, P392, DOI 10.1002/nau.22428
   Kokanali MK, 2016, J OBSTET GYNAECOL, V36, P1080, DOI 10.1080/01443615.2016.1209169
   Krambeck A, 2017, J ENDOUROL, V31, P20, DOI 10.1089/end.2016.0514
   Lafranca JA, 2015, BMC MED, V13, DOI 10.1186/s12916-015-0340-5
   Leruth J, 2012, EUR UROL, V61, P608, DOI 10.1016/j.eururo.2011.10.036
   Lo TS, 2013, INT UROGYNECOL J, V24, P809, DOI 10.1007/s00192-012-1940-7
   Lynch RJ, 2009, ANN SURG, V250, P1014, DOI 10.1097/SLA.0b013e3181b4ee9a
   Machin Sarah Elizabeth, 2011, Menopause Int, V17, P132, DOI 10.1258/mi.2011.011108
   Meschia M, 2013, EUR J OBSTET GYN R B, V170, P571, DOI 10.1016/j.ejogrb.2013.08.007
   MOMMSEN S, 1994, WORLD J UROL, V12, P319
   Mondul AM, 2014, J UROLOGY, V191, P715, DOI 10.1016/j.juro.2013.08.110
   Mosli HA, 2012, UROLOGY, V80, P974, DOI 10.1016/j.urology.2012.07.027
   Must A, 2000, DIS BURDEN ASSOCIATE
   Myers DL, 2012, FEMALE PELVIC MED RE, V18, P55, DOI 10.1097/SPV.0b013e31824171f9
   Orlic L, 2015, INT J CLIN PRACT, V69, P1357, DOI 10.1111/ijcp.12715
   Ozgor F, 2016, WORLD J UROL, V34, P1169, DOI 10.1007/s00345-015-1745-7
   Ozgor F, 2016, UROL J, V13, P2471
   Pereira I, 2016, INT UROGYNECOL J, V27, P247, DOI 10.1007/s00192-015-2820-8
   Pinto H, 2017, TRANSPL P, V49, P821, DOI 10.1016/j.transproceed.2017.03.010
   Ramalingam K, 2015, BEST PRACT RES CL OB, V29, P541, DOI 10.1016/j.bpobgyn.2015.02.002
   Romero-Corral A, 2008, INT J OBESITY, V32, P959, DOI 10.1038/ijo.2008.11
   Sener NC, 2015, J ENDOUROL, V29, P340, DOI 10.1089/end.2014.0207
   Serati M, 2017, NEUROUROL URODYNAM, V36, P192, DOI 10.1002/nau.22914
   Sievert KD, 2017, CURR OPIN UROL, V27, P287, DOI 10.1097/MOU.0000000000000386
   Simsek A, 2014, TURK J UROL, V40, P104, DOI 10.5152/tud.2014.66674
   Sirls LT, 2013, FEMALE PELVIC MED RE, V19, P206, DOI 10.1097/SPV.0b013e318298b381
   Subak LL, 2009, J UROLOGY, V182, pS2, DOI 10.1016/j.juro.2009.08.071
   Taylor EN, 2005, JAMA-J AM MED ASSOC, V293, P455, DOI 10.1001/jama.293.4.455
   Tjeertes EEKM, 2015, BMC ANESTHESIOL, V15, DOI 10.1186/s12871-015-0096-7
   Ortiz CT, 2014, UROLOGY, V84, P538, DOI 10.1016/j.urology.2014.03.062
   Tremblay S, 2016, PROG TRANSPLANT, V26, P183, DOI 10.1177/1526924816640679
   Trudeau V, 2016, J ENDOUROL, V30, P864, DOI 10.1089/end.2015.0789
   Türk C, 2016, EUR UROL, V69, P475, DOI 10.1016/j.eururo.2015.07.041
   Viers BR, 2016, UROLOGY, V98, P176, DOI 10.1016/j.urology.2016.06.038
   Wang R, 2012, UROLOGY, V79, P922, DOI 10.1016/j.urology.2011.11.051
   Wang S, 2012, PROSTATE CANCER P D, V15, P265, DOI 10.1038/pcan.2011.65
   Weltz V, 2015, INT UROGYNECOL J, V26, P641, DOI 10.1007/s00192-014-2567-7
   Whitcomb EL, 2011, RES REP UROL, V3, P123, DOI 10.2147/OAJU.S21091
   World Health Organization, 2016, OB OV FACT SHEET NO
   Yang TK, 2015, J FORMOS MED ASSOC, V114, P268, DOI 10.1016/j.jfma.2012.11.012
   Zhou XJ, 2017, UROL INT, V98, P382, DOI 10.1159/000455162
NR 68
TC 3
Z9 3
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0963-0643
EI 1473-6586
J9 CURR OPIN UROL
JI Curr. Opin. Urol.
PD SEP
PY 2017
VL 27
IS 5
BP 456
EP 463
DI 10.1097/MOU.0000000000000430
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA FB9OR
UT WOS:000406469100009
PM 28650868
DA 2025-06-11
ER

PT J
AU Akanji, AO
   Ohaeri, JU
   Al-Shammri, SA
   Fatania, HR
AF Akanji, A. O.
   Ohaeri, J. U.
   Al-Shammri, S. A.
   Fatania, H. R.
TI Associations of blood homocysteine concentrations in Arab schizophrenic
   patients
SO CLINICAL BIOCHEMISTRY
LA English
DT Article
DE Arabs; schizophrenia; homocysteine; lipoproteins; oxidative stress;
   disease phenotypes
ID METHYLENETETRAHYDROFOLATE REDUCTASE POLYMORPHISM; PLASMA HOMOCYSTEINE;
   SERUM HOMOCYSTEINE; METABOLIC SYNDROME; RISK-FACTOR; FOLATE;
   HYPERHOMOCYSTEINEMIA; PREVALENCE; DEMENTIA; C677T
AB Background: This study aimed to evaluate the blood homocysteine concentration in Arab patients with schizophrenia and assess its associations with clinical phenotypes of the disease.
   Subjects and methods: Two age-matched groups of subjects were studied: (1) Healthy Controls, HC, n = 165; (2) patients with schizophrenia, SZ: n = 207. Each subject was evaluated with a standard questionnaire for age at disease onset, family history, disease severity and outcome. Plasma homocysteine levels (Hcys) were measured by immunoassay and serum levels of other biochemical parameters were measured by routine Autoanalyzer techniques.
   Results and discussion: Group HC was heavier (body mass index, BMI) while SZ bad greater waist-hip ratio (WHR) and plasma Hcys levels. In SZ, there were significant correlations between Heys and BMI, triglycerides and HDL. Heys levels in SZ were highest in the younger male patients.
   Conclusion: Schizophrenic patients have increased blood Hcys levels which correlate with components of the metabolic syndrome. Hcys levels were highest in the younger male patients and were not influenced by prognostic features of the disease. (c) 2007 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
C1 Kuwait Univ, Fac Med, Dept Pathol, Clin Chem Unit, Safat 13110, Kuwait.
   Kuwait Univ, Fac Med, Dept Med, Safat 13060, Kuwait.
   Kuwait Univ, Fac Med, Dept Biochem, Safat 13060, Kuwait.
C3 Kuwait University; Kuwait University; Kuwait University
RP Akanji, AO (corresponding author), Kuwait Univ, Fac Med, Dept Pathol, Clin Chem Unit, POB 24923, Safat 13110, Kuwait.
EM abayomi@hse.edu.kw
RI Akanji, Abayomi/AAY-4732-2021
CR Abu-Amero KK, 2003, ARCH PATHOL LAB MED, V127, P1349
   ALANSARI EA, 1989, COMPR PSYCHIAT, V30, P416, DOI 10.1016/0010-440X(89)90007-2
   Almawi WY, 2004, AM J HEMATOL, V76, P85, DOI 10.1002/ajh.20047
   American Psychiatric Association (APA), 2013, Diagnostic and Statistical Manual of Mental Disorders, V5th ed
   [Anonymous], 1981, Scale for the assessment of negative symptoms
   ANTUN FT, 1971, J PSYCHIAT RES, V8, P63, DOI 10.1016/0022-3956(71)90009-4
   Applebaum J, 2004, J PSYCHIATR RES, V38, P413, DOI 10.1016/j.jpsychires.2004.01.003
   Brown AS, 2005, PROG NEURO-PSYCHOPH, V29, P1175, DOI 10.1016/j.pnpbp.2005.06.028
   Bu R, 2004, PHARMACOGENOMICS J, V4, P260, DOI 10.1038/sj.tpj.6500251
   Chen JY, 1999, NEUROPSYCHOBIOLOGY, V39, P141, DOI 10.1159/000026573
   Clarke R, 1998, ARCH NEUROL-CHICAGO, V55, P1449, DOI 10.1001/archneur.55.11.1449
   COHEN SM, 1974, BIOL PSYCHIAT, V8, P209
   Diaz-Arrastia R, 1998, ARCH NEUROL-CHICAGO, V55, P1407, DOI 10.1001/archneur.55.11.1407
   el-Hilu S M, 1990, Int J Soc Psychiatry, V36, P291, DOI 10.1177/002076409003600407
   Fan XD, 2007, PSYCHIAT RES, V149, P267, DOI 10.1016/j.psychres.2006.07.011
   FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
   Geisel J, 2003, CLIN CHEM LAB MED, V41, P1427, DOI 10.1515/CCLM.2003.219
   Goff DC, 2004, AM J PSYCHIAT, V161, P1705, DOI 10.1176/appi.ajp.161.9.1705
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Hägg S, 2006, INT CLIN PSYCHOPHARM, V21, P93
   Hankey GJ, 2006, NAT CLIN PRACT NEURO, V2, P26, DOI 10.1038/ncpneuro0093
   Henderson DC, 2006, ACTA PSYCHIAT SCAND, V113, P121, DOI 10.1111/j.1600-0447.2005.00621.x
   Hennekens CH, 2005, AM HEART J, V150, P1115, DOI 10.1016/j.ahj.2005.02.007
   Jacques PF, 1996, CIRCULATION, V93, P7, DOI 10.1161/01.CIR.93.1.7
   Kannel WB, 2005, LIPIDS, V40, P1215, DOI 10.1007/s11745-005-1488-8
   Kaul S, 2006, J AM COLL CARDIOL, V48, P914, DOI 10.1016/j.jacc.2006.04.086
   KAY SR, 1990, SCHIZOPHRENIA BULL, V16, P537, DOI 10.1093/schbul/16.3.537
   Kerkeni M, 2006, ANN CLIN BIOCHEM, V43, P200, DOI 10.1258/000456306776865232
   Kruman II, 2000, J NEUROSCI, V20, P6920, DOI 10.1523/JNEUROSCI.20-18-06920.2000
   Lee YS, 2006, NEUROREPORT, V17, P743, DOI 10.1097/01.wnr.0000215777.99473.52
   Lerner V, 2005, J CLIN PSYCHIAT, V66, P1558, DOI 10.4088/JCP.v66n1210
   Levine J, 2005, PROG NEURO-PSYCHOPH, V29, P1181, DOI 10.1016/j.pnpbp.2005.06.029
   Levine J, 2002, AM J PSYCHIAT, V159, P1790, DOI 10.1176/appi.ajp.159.10.1790
   Malasi T H, 1989, Int J Soc Psychiatry, V35, P223, DOI 10.1177/002076408903500302
   McCaddon A, 1998, INT J GERIATR PSYCH, V13, P235, DOI 10.1002/(SICI)1099-1166(199804)13:4<235::AID-GPS761>3.0.CO;2-8
   McEvoy JP, 2005, SCHIZOPHR RES, V80, P19, DOI 10.1016/j.schres.2005.07.014
   Muntjewerff JW, 2005, AM J MED GENET B, V135B, P69, DOI 10.1002/ajmg.b.30179
   Nevo GA, 2006, EUR NEUROPSYCHOPHARM, V16, P588, DOI 10.1016/j.euroneuro.2006.03.006
   Picker JD, 2005, HARVARD REV PSYCHIAT, V13, P197, DOI 10.1080/10673220500243372
   POLLIN W, 1961, SCIENCE, V133, P104, DOI 10.1126/science.133.3446.104
   Ramakrishnan S, 2006, INDIAN J BIOCHEM BIO, V43, P275
   REGLAND B, 1995, J NEURAL TRANSM-GEN, V100, P165, DOI 10.1007/BF01271539
   Reif A, 2005, PROG NEURO-PSYCHOPH, V29, P1162, DOI 10.1016/j.pnpbp.2005.06.027
   Reif A, 2003, J NEURAL TRANSM, V110, P1401, DOI 10.1007/s00702-003-0061-3
   Seshadri S, 2002, NEW ENGL J MED, V346, P476, DOI 10.1056/NEJMoa011613
   Stahl Z, 2005, EUR NEUROPSYCHOPHARM, V15, P291, DOI 10.1016/j.euroneuro.2004.12.003
   Vilella E, 2005, PROG NEURO-PSYCHOPH, V29, P1169, DOI 10.1016/j.pnpbp.2005.07.001
   Virgos C, 1999, NEUROREPORT, V10, P2035, DOI 10.1097/00001756-199907130-00008
   Weisberg I, 1998, MOL GENET METAB, V64, P169, DOI 10.1006/mgme.1998.2714
   Weisberg IS, 2001, ATHEROSCLEROSIS, V156, P409, DOI 10.1016/S0021-9150(00)00671-7
   WING JK, 1990, ARCH GEN PSYCHIAT, V47, P589
   World Health Organization, 1992, International statistical classification of diseases and related health problems; Tenth Revision (ICD-10)
   Zhang XY, 2002, SCHIZOPHR RES, V57, P247, DOI 10.1016/S0920-9964(01)00296-1
NR 53
TC 32
Z9 33
U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
EI 1873-2933
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD SEP
PY 2007
VL 40
IS 13-14
BP 1026
EP 1031
DI 10.1016/j.clinbiochem.2007.06.001
PG 6
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 209XV
UT WOS:000249422200018
PM 17601525
DA 2025-06-11
ER

PT J
AU de Souza, JA
   Vindis, C
   Hansel, B
   Négre-Salvayre, A
   Therond, P
   Serrano, CV
   Chantepie, S
   Salvayre, R
   Bruckert, E
   Chapman, MJ
   Kontush, A
AF de Souza, Juliana A.
   Vindis, Cecile
   Hansel, Boris
   Negre-Salvayre, Anne
   Therond, Patrice
   Serrano, Carlos V., Jr.
   Chantepie, Sandrine
   Salvayre, Robert
   Bruckert, Eric
   Chapman, M. John
   Kontush, Anatol
TI Metabolic syndrome features small, apolipoprotein A-I-poor,
   triglyceride-rich HDL3 particles with defective anti-apoptotic activity
SO ATHEROSCLEROSIS
LA English
DT Article
DE reactive oxygen species; annexin V; Sphingosine-1-phosphate;
   anti-apoptotic activity; antioxidative activity
ID HIGH-DENSITY-LIPOPROTEIN; ELEVATED OXIDATIVE STRESS; PREVENT CELL-DEATH;
   ENDOTHELIAL-CELLS; ANTIOXIDATIVE ACTIVITY; OXIDIZED LDL; SPHINGOSINE
   1-PHOSPHATE; CARDIOVASCULAR-DISEASE; CHOLESTEROL EFFLUX;
   INSULIN-RESISTANCE
AB The metabolic syndrome (MetS) phenotype is typically characterized by visceral obesity, insulin resistance, atherogenic dyslipidemia involving hypertriglyceridemia and subnormal levels of high density lipoprotein-cholesterol (HDL-C), oxidative stress and elevated cardiovascular risk. The potent antioxidative activity of small HDL3 is defective in MetS [Hansel B, et al. J Clin Endocrinol Metab 2004;89:4963-71]. We evaluated the functional capacity of small HDL3 particles from MetS subjects to protect endothelial cells from apoptosis induced by mildly oxidized low-density lipoprotein (oxLDL).
   MetS subjects presented an insulin-resistant obese phenotype, with hypertriglyceridemia, elevated apolipoprotein B and insulin levels, but subnormal HDL-C concentrations and chronic low grade inflammation (threefold elevation of C-reactive protein). When human microvascular endothelial cells (HMEC-1) were incubated with oxLDL (200 jig apolipoprotein B/ml) in the presence or absence of control HDL subfiractions (25 mu g protein/ml), small, dense HDL3b and 3c significantly inhibited cellular annexin V binding and intracellular generation of reactive oxygen species. The potent anti-apoptotic activity of small HDL3c particles was reduced (-35%; p < 0.05) in MetS subjects (n = 16) relative to normolipidemic controls (n = 7). The attenuated anti-apoptotic activity of HDL3c correlated with abdominal obesity, atherogenic dyslipidemia and systemic oxidative stress (p < 0.05), and was intimately associated with altered physicochemical properties of apolipoprotein A-I (apoA-I-poor HDL3c, involving core cholesteryl ester depletion and triglyceride enrichment.
   We conclude that in MetS, apoA-I-poor, small, dense HDL3c exert defective protection of endothelial cells from oxLDL-induced apoptosis, potentially reflecting functional anomalies intimately associated with abnormal neutral lipid core content. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
C1 [de Souza, Juliana A.; Chantepie, Sandrine; Chapman, M. John; Kontush, Anatol] Univ Paris 06, F-75013 Paris, France.
   [de Souza, Juliana A.; Hansel, Boris; Chantepie, Sandrine; Bruckert, Eric; Chapman, M. John; Kontush, Anatol] Grp Hosp Pitie Salpetriere, AP HP, F-75013 Paris, France.
   [de Souza, Juliana A.; Hansel, Boris; Therond, Patrice; Chantepie, Sandrine; Chapman, M. John; Kontush, Anatol] INSERM, Dyalipopreteinemia & Anthrosclerosis Res Unit 551, F-75013 Paris, France.
   [de Souza, Juliana A.; Serrano, Carlos V., Jr.] Univ Sao Paulo, Inst Heart, Sao Paulo, Brazil.
   [Vindis, Cecile; Negre-Salvayre, Anne; Salvayre, Robert] CHU Rangueli, INSERM, Unit 466, Toulouse, France.
   [Therond, Patrice] Univ Paris 05, Dept Biochem, F-75005 Paris, France.
C3 Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Pitie-Salpetriere - APHP; Sorbonne Universite; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universidade
   de Sao Paulo; Institut National de la Sante et de la Recherche Medicale
   (Inserm); CHU de Toulouse; Universite Paris Cite
RP Kontush, A (corresponding author), Hop Pitie, INSERM, Uniye 551, Pavillon Benjamin,83 Blvd Hop, F-75651 Paris 13, France.
EM kontush@chupsjussieu.fr; kontush@chups.jussieu.fr
RI Serrano, Carlos/I-2729-2013; Vindis, Cécile/AAH-2708-2019; Kontush,
   Anatol/J-2198-2016; chapman, john/Y-2742-2019
OI Vindis, Cecile/0000-0003-2421-1155; Kontush, Anatol/0000-0002-9008-7335;
   CHANTEPIE-LABORDE, Sandrine/0000-0003-1652-432X; Negre-Salvayre,
   Anne/0000-0003-2136-5706
CR Adeli K, 2001, TRENDS CARDIOVAS MED, V11, P170, DOI 10.1016/S1050-1738(01)00084-6
   Alexander CM, 2003, DIABETES, V52, P1210, DOI 10.2337/diabetes.52.5.1210
   Ashby DT, 1998, ARTERIOSCL THROM VAS, V18, P1450, DOI 10.1161/01.ATV.18.9.1450
   Assmann G, 2003, ANNU REV MED, V54, P321, DOI 10.1146/annurev.med.54.101601.152409
   Boersma HH, 2005, J NUCL MED, V46, P2035
   Bonora E, 2002, DIABETES CARE, V25, P1135, DOI 10.2337/diacare.25.7.1135
   CHAPMAN MJ, 1981, J LIPID RES, V22, P339
   CURRY MD, 1981, CLIN CHEM, V27, P543
   Curtiss LK, 2000, BIOCHEMISTRY-US, V39, P5712, DOI 10.1021/bi992902m
   EscargueilBlanc I, 1997, ARTERIOSCL THROM VAS, V17, P331, DOI 10.1161/01.ATV.17.2.331
   ESTERBAUER H, 1992, FREE RADICAL BIO MED, V13, P341, DOI 10.1016/0891-5849(92)90181-F
   ESTERBAUER H, 1989, FREE RADICAL RES COM, V6, P67, DOI 10.3109/10715768909073429
   Guerin M, 2002, ATHEROSCLEROSIS, V163, P287, DOI 10.1016/S0021-9150(02)00037-0
   Gugliucci A, 1998, LIFE SCI, V62, P2141, DOI 10.1016/S0024-3205(98)00189-1
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Hedrick CC, 2000, DIABETOLOGIA, V43, P312, DOI 10.1007/s001250050049
   Holvoet P, 2004, DIABETES, V53, P1068, DOI 10.2337/diabetes.53.4.1068
   Khovidhunkit W, 2004, J LIPID RES, V45, P1169, DOI 10.1194/jlr.R300019-JLR200
   Kimura T, 2003, ARTERIOSCL THROM VAS, V23, P1283, DOI 10.1161/01.ATV.0000079011.67194.5A
   Kimura T, 2001, J BIOL CHEM, V276, P31780, DOI 10.1074/jbc.M104353200
   Kolmakova A, 2004, ARTERIOSCL THROM VAS, V24, P264, DOI 10.1161/01.ATV.0000112036.72200.ac
   Kontush A, 2006, NAT CLIN PRACT CARD, V3, P144, DOI 10.1038/ncpcardio0500
   Kontush A, 2005, ATHEROSCLEROSIS, V182, P277, DOI 10.1016/j.atherosclerosis.2005.03.001
   Kontush A, 2002, FASEB J, V16, P88, DOI 10.1096/fj.02-0293fje
   Kontush A, 2003, ARTERIOSCL THROM VAS, V23, P1881, DOI 10.1161/01.ATV.0000091338.93223.E8
   Le Goff W, 2004, PHARMACOL THERAPEUT, V101, P17, DOI 10.1016/j.pharmthera.2003.10.001
   Lefevre G, 1997, CLIN CHIM ACTA, V258, P249, DOI 10.1016/S0009-8981(96)06462-5
   Lusis AJ, 2000, NATURE, V407, P233, DOI 10.1038/35025203
   MCCONKEY DJ, 1989, FASEB J, V3, P1843, DOI 10.1096/fasebj.3.7.2497041
   Meilhac O, 1999, FASEB J, V13, P485, DOI 10.1096/fasebj.13.3.485
   Napoli C, 2000, FASEB J, V14, P1996, DOI 10.1096/fj.99-0986com
   Navab M, 2000, J LIPID RES, V41, P1481
   Nobécourt E, 2005, DIABETOLOGIA, V48, P529, DOI 10.1007/s00125-004-1655-5
   Nofer JR, 2001, J BIOL CHEM, V276, P34480, DOI 10.1074/jbc.M103782200
   Nofer JR, 2004, J CLIN INVEST, V113, P569, DOI 10.1172/JCI200418004
   OHTA T, 1995, ARTERIOSCL THROM VAS, V15, P956, DOI 10.1161/01.ATV.15.7.956
   REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
   RUMSEY SC, 1994, J LIPID RES, V35, P1592
   Ruotolo Giacomo, 2002, Curr Cardiol Rep, V4, P494, DOI 10.1007/s11886-002-0113-6
   Salvayre R, 2002, BBA-MOL CELL BIOL L, V1585, P213, DOI 10.1016/S1388-1981(02)00343-8
   Sevanian A, 1996, ARTERIOSCL THROM VAS, V16, P784, DOI 10.1161/01.ATV.16.6.784
   SOLA R, 1990, BIOCHIM BIOPHYS ACTA, V1043, P43, DOI 10.1016/0005-2760(90)90108-A
   SPARKS DL, 1995, J BIOL CHEM, V270, P26910, DOI 10.1074/jbc.270.45.26910
   Stocker R, 2004, PHYSIOL REV, V84, P1381, DOI 10.1152/physrev.00047.2003
   Suc I, 1997, ARTERIOSCL THROM VAS, V17, P2158, DOI 10.1161/01.ATV.17.10.2158
   Sugano M, 2000, BIOCHEM BIOPH RES CO, V272, P872, DOI 10.1006/bbrc.2000.2877
   Waeber C, 2004, DRUG NEWS PERSPECT, V17, P365, DOI 10.1358/dnp.2004.17.6.829028
   Zheng LM, 2004, J CLIN INVEST, V114, P529, DOI 10.1172/JCI200421109
NR 48
TC 99
Z9 108
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD MAR
PY 2008
VL 197
IS 1
BP 84
EP 94
DI 10.1016/j.atherosclerosis.2007.08.009
PG 11
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 282LS
UT WOS:000254569900010
PM 17868679
DA 2025-06-11
ER

PT J
AU Fresta, CG
   Fidilio, A
   Lazzarino, G
   Musso, N
   Grasso, M
   Merlo, S
   Amorini, AM
   Bucolo, C
   Tavazzi, B
   Lazzarino, G
   Lunte, SM
   Caraci, F
   Caruso, G
AF Fresta, Claudia G.
   Fidilio, Annamaria
   Lazzarino, Giacomo
   Musso, Nicolo
   Grasso, Margherita
   Merlo, Sara
   Amorini, Angela M.
   Bucolo, Claudio
   Tavazzi, Barbara
   Lazzarino, Giuseppe
   Lunte, Susan M.
   Caraci, Filippo
   Caruso, Giuseppe
TI Modulation of Pro-Oxidant and Pro-Inflammatory Activities of M1
   Macrophages by the Natural Dipeptide Carnosine
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE carnosine; M1 macrophages; nitric oxide; oxidative stress; inflammation;
   antioxidants; energy metabolism
ID NITRIC-OXIDE PRODUCTION; MICROCHIP ELECTROPHORESIS; COGNITIVE DEFICITS;
   OXIDATIVE STRESS; SUPEROXIDE-PRODUCTION; ALZHEIMERS-DISEASE; CELLS;
   TGF-BETA-1; INCREASES; MUSCLE
AB Carnosine is a natural endogenous dipeptide widely distributed in mammalian tissues, existing at particularly high concentrations in the muscles and brain and possesses well-characterized antioxidant and anti-inflammatory activities. In an in vitro model of macrophage activation, induced by lipopolysaccharide + interferon-gamma (LPS + IFN-gamma), we here report the ability of carnosine to modulate pro-oxidant and pro-inflammatory activities of macrophages, representing the primary cell type that is activated as a part of the immune response. An ample set of parameters aimed to evaluate cytotoxicity (MTT assay), energy metabolism (HPLC), gene expressions (high-throughput real-time PCR (qRT-PCR)), protein expressions (western blot) and nitric oxide production (qRT-PCR and HPLC), was used to assess the effects of carnosine on activated macrophages challenged with a non cytotoxic LPS (100 ng/mL) + IFN-gamma (600 U/mL) concentration. In our experimental model, main carnosine beneficial e ffects were: (1) the modulation of nitric oxide production and metabolism; (2) the amelioration of the macrophage energy state; (3) the decrease of the expressions of pro-oxidant enzymes (Nox-2, Cox-2) and of the lipid peroxidation product malondialdehyde; (4) the restoration and/or increase of the expressions of antioxidant enzymes (Gpx1, SOD-2 and Cat); (5) the increase of the transforming growth factor-beta 1 (TGF-beta 1) and the down-regulation of the expressions of interleukins 1 beta and 6 (IL-1 beta and IL-6) and 6) the increase of the expressions of Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and heme oxygenase-1 (HO-1). According to these results carnosine is worth being tested in the treatment of diseases characterized by elevated levels of oxidative stress and inflammation (atherosclerosis, cancer, depression, metabolic syndrome, and neurodegenerative diseases).
C1 [Fresta, Claudia G.; Lunte, Susan M.] Univ Kansas, Ralph N Adams Inst Bioanalyt Chem, Lawrence, KS 66047 USA.
   [Fresta, Claudia G.; Lunte, Susan M.] Univ Kansas, Dept Pharmaceut Chem, Lawrence, KS 66047 USA.
   [Fidilio, Annamaria; Grasso, Margherita; Caraci, Filippo] Univ Catania, Dept Drug Sci, I-95125 Catania, Italy.
   [Lazzarino, Giacomo] UniCamillus St Camillus Int Univ Hlth Sci, I-00131 Rome, Italy.
   [Musso, Nicolo] Univ Catania, BRIT, I-95125 Catania, Italy.
   [Grasso, Margherita; Caraci, Filippo; Caruso, Giuseppe] IRCCS, Oasi Res Inst, I-94018 Troina, EN, Italy.
   [Merlo, Sara; Amorini, Angela M.; Bucolo, Claudio; Lazzarino, Giuseppe] Univ Catania, Dept Biomed & Biotechnol Sci, I-95125 Catania, Italy.
   [Tavazzi, Barbara] Univ Cattolica Sacro Cuore, Inst Biochem & Clin Biochem, I-00168 Rome, Italy.
   [Tavazzi, Barbara] Fdn Policlin Univ A Gemelli IRCCS, I-00168 Rome, Italy.
   [Lunte, Susan M.] Univ Kansas, Dept Chem, Lawrence, KS 66047 USA.
   [Fresta, Claudia G.] Univ Catania, Dept Biomed & Biotechnol Sci, PhD Program Neurosci, I-95125 Catania, Italy.
C3 University of Kansas; University of Kansas; University of Catania;
   University of Catania; IRCCS - Oasi Research Institute; University of
   Catania; Catholic University of the Sacred Heart; IRCCS Policlinico
   Gemelli; Catholic University of the Sacred Heart; IRCCS Policlinico
   Gemelli; University of Kansas; University of Catania
RP Caruso, G (corresponding author), IRCCS, Oasi Res Inst, I-94018 Troina, EN, Italy.; Lazzarino, G (corresponding author), Univ Catania, Dept Biomed & Biotechnol Sci, I-95125 Catania, Italy.
EM forclaudiafresta@gmail.com; afunict@gmail.com; lazzarig@unict.it;
   nmusso@unict.it; grassomargherita940@gmail.com; sara_merlo@hotmail.com;
   amorini@unict.it; claudio.bucolo@unict.it; barbara.tavazzi@unicatt.it;
   giacomo.lazzarino@unicamillus.org; slunte@ku.edu; carafil@hotmail.com;
   forgiuseppecaruso@gmail.com
RI MUSSO, Nicolo'/CAH-2950-2022; Lazzarino, Giacomo/IQT-0407-2023; Lunte,
   Susan/G-2263-2018; TAVAZZI, BARBARA/AAB-9830-2019; Merlo,
   Sara/X-3872-2019; Caruso, Giuseppe/C-1435-2018; lazzarino,
   giuseppe/K-2277-2015; Caraci, Filippo/K-2262-2016; Fidilio,
   Annamaria/GNP-1855-2022; Grasso, Margherita/AAB-6242-2019
OI Caruso, Giuseppe/0000-0003-1571-5327; lazzarino,
   giuseppe/0000-0002-5917-7279; Merlo, Sara/0000-0002-6558-9800; Caraci,
   Filippo/0000-0002-9867-6054; TAVAZZI, BARBARA/0000-0001-8743-0895;
   Fidilio, Annamaria/0000-0002-9279-0171; MUSSO,
   Nicolo'/0000-0003-2451-1158; Grasso, Margherita/0000-0003-4458-5226;
   Fresta, Claudia Giuseppina/0000-0002-8113-6457; AMORINI, Angela
   Maria/0000-0003-3525-9955; Lazzarino, Giacomo/0000-0003-1639-0966
FU American Heart Association (Midwest Affiliate Postdoctoral Research
   Fellowship) [NFP0075515]; Italian Ministry of Health Research Program
   [RC: 2635256]
FX GC received support from the American Heart Association (Midwest
   Affiliate Postdoctoral Research Fellowship), grant number NFP0075515.
   G.C. and F.C. would like to acknowledge the support received from the
   Italian Ministry of Health Research Program 2018, grant number RC:
   2635256.
CR Abbas K, 2014, FREE RADICAL BIO MED, V71, P281, DOI 10.1016/j.freeradbiomed.2014.03.019
   Ahshin-Majd S, 2016, PEPTIDES, V86, P102, DOI 10.1016/j.peptides.2016.10.008
   Aktan F, 2004, LIFE SCI, V75, P639, DOI 10.1016/j.lfs.2003.10.042
   Albrecht T, 2017, SCI REP-UK, V7, DOI 10.1038/srep44492
   Amorini AM, 2016, BBA-MOL BASIS DIS, V1862, P679, DOI 10.1016/j.bbadis.2016.01.023
   Artioli GG, 2010, MED SCI SPORT EXER, V42, P1162, DOI 10.1249/MSS.0b013e3181c74e38
   Barresi V, 2010, BMC MED GENOMICS, V3, DOI 10.1186/1755-8794-3-28
   Biswas SK, 2012, IMMUNOL RES, V53, P11, DOI 10.1007/s12026-012-8291-9
   Bogdan C, 2001, NAT IMMUNOL, V2, P907, DOI 10.1038/ni1001-907
   Brand MD, 2011, BIOCHEM J, V435, P297, DOI 10.1042/BJ20110162
   Budzen S, 2013, ADV CLIN EXP MED, V22, P739
   Campbell IL, 2014, J NEUROSCI, V34, P2503, DOI 10.1523/JNEUROSCI.2830-13.2014
   Caraci F, 2018, PHARMACOL RES, V130, P374, DOI 10.1016/j.phrs.2018.02.007
   Caraci F, 2015, SCI REP-UK, V5, DOI 10.1038/srep11252
   Caraci F, 2012, EUR NEUROPSYCHOPHARM, V22, P281, DOI 10.1016/j.euroneuro.2011.08.006
   Caruso G, 2019, CURR MED CHEM
   Caruso G, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8080281
   Caruso G, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8010064
   Caruso G, 2019, PROG NEUROBIOL, V175, P35, DOI 10.1016/j.pneurobio.2018.12.004
   Caruso G, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19113659
   Caruso G, 2017, ANAL BIOANAL CHEM, V409, P4529, DOI 10.1007/s00216-017-0401-z
   Caruso G, 2017, MOL CELL BIOCHEM, V431, P197, DOI 10.1007/s11010-017-2991-3
   Caruso G, 2017, MOL CELL BIOCHEM, V425, P85, DOI 10.1007/s11010-016-2864-1
   Chen JH, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0116549
   Choi SY, 1999, BBA-GEN SUBJECTS, V1472, P651, DOI 10.1016/S0304-4165(99)00189-0
   Church LD, 2008, NAT CLIN PRACT RHEUM, V4, P34, DOI 10.1038/ncprheum0681
   Church LD, 2006, SPRINGER SEMIN IMMUN, V27, P494, DOI 10.1007/s00281-006-0015-6
   Cuschieri J, 2007, ANTIOXID REDOX SIGN, V9, P1485, DOI 10.1089/ars.2007.1670
   De Carlo RM, 2015, ANAL BIOANAL CHEM, V407, P1217, DOI 10.1007/s00216-014-8339-x
   DeVan AE, 2016, J APPL PHYSIOL, V120, P416, DOI 10.1152/japplphysiol.00879.2015
   Dong J, 2008, ANTIOXID REDOX SIGN, V10, P2023, DOI 10.1089/ars.2007.2019
   Estévez AG, 2002, ANN NY ACAD SCI, V962, P207, DOI 10.1111/j.1749-6632.2002.tb04069.x
   Fedorova TN, 2009, BIOCHEM MOSC SUPPL S, V3, P62, DOI 10.1134/S1990747809010085
   Feduska JM, 2018, FREE RADICAL BIO MED, V125, P81, DOI 10.1016/j.freeradbiomed.2018.04.581
   Fisichella V, 2016, EUR J PHARMACOL, V787, P72, DOI 10.1016/j.ejphar.2016.02.002
   Fleisher-Berkovich S, 2009, PEPTIDES, V30, P1306, DOI 10.1016/j.peptides.2009.04.003
   Fresta CG, 2018, CELL DEATH DIS, V9, DOI 10.1038/s41419-018-0280-z
   Fresta CG, 2017, ANAL METHODS-UK, V9, P402, DOI [10.1039/c6ay03009b, 10.1039/C6AY03009B]
   GOUDA W., 2018, Bulletin of the National Research Centre, V42, P14, DOI DOI 10.1186/S42269-018-0016-3
   Herculano B, 2013, J ALZHEIMERS DIS, V33, P983, DOI 10.3233/JAD-2012-121324
   Hipkiss AR, 1998, ANN NY ACAD SCI, V854, P37, DOI 10.1111/j.1749-6632.1998.tb09890.x
   Hu L, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0212138
   Huang Y, 2015, J NUTR BIOCHEM, V26, P1401, DOI 10.1016/j.jnutbio.2015.08.001
   Jager J, 2007, ENDOCRINOLOGY, V148, P241, DOI 10.1210/en.2006-0692
   Kang KA, 2017, TOX RESEARCH, V33, P1, DOI 10.5487/TR.2017.33.1.001
   Kolodziej H, 2008, PHYTOCHEMISTRY, V69, P3103, DOI 10.1016/j.phytochem.2007.11.012
   Kulkarni AB, 1997, RES IMMUNOL, V148, P453, DOI 10.1016/S0923-2494(97)82669-7
   Kwon DH, 2018, INT J MOL MED, V41, P264, DOI 10.3892/ijmm.2017.3209
   Lazzarino G, 2003, ANAL BIOCHEM, V322, P51, DOI 10.1016/j.ab.2003.07.013
   Lazzarino G, 2018, HUM REPROD, V33, P1817, DOI 10.1093/humrep/dey279
   Lee S, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0222857
   Li N, 2011, CANCER CELL, V19, P429, DOI 10.1016/j.ccr.2011.03.018
   Li Volti G, 2017, ANTIOXID REDOX SIGN, V27, P363, DOI 10.1089/ars.2016.6735
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   Lopalco G, 2017, FRONT IMMUNOL, V8, DOI 10.3389/fimmu.2017.00200
   Lucas K, 2013, MOL NEUROBIOL, V48, P190, DOI 10.1007/s12035-013-8425-7
   Lucherini OM, 2018, IMMUNOL LETT, V201, P38, DOI 10.1016/j.imlet.2018.10.013
   Macedo LW, 2016, MOL NEUROBIOL, V53, P5582, DOI 10.1007/s12035-015-9475-9
   Malagoli D, 2017, BIOL REV, V92, P369, DOI 10.1111/brv.12234
   Maldonado EN, 2014, MITOCHONDRION, V19, P78, DOI 10.1016/j.mito.2014.09.002
   MANDRUPPOULSEN T, 1986, DIABETOLOGIA, V29, P63, DOI 10.1007/BF02427283
   MANNION AF, 1992, EUR J APPL PHYSIOL O, V64, P47, DOI 10.1007/BF00376439
   Marriott HM, 2004, FASEB J, V18, P1126, DOI 10.1096/fj.03-1450fje
   Martinez FO, 2009, ANNU REV IMMUNOL, V27, P451, DOI 10.1146/annurev.immunol.021908.132532
   Martinon F, 2006, NATURE, V440, P237, DOI 10.1038/nature04516
   McHugh J, 1998, Am J Crit Care, V7, P131
   Naito Y, 2014, ARCH BIOCHEM BIOPHYS, V564, P83, DOI 10.1016/j.abb.2014.09.005
   Ooi TC, 2017, IMMUNOPHARM IMMUNOT, V39, P259, DOI 10.1080/08923973.2017.1344987
   Ouyang L, 2016, BRAIN RES BULL, V124, P76, DOI 10.1016/j.brainresbull.2016.03.019
   Pacher P, 2007, PHYSIOL REV, V87, P315, DOI 10.1152/physrev.00029.2006
   Platania CBM, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18102076
   Raffaele M, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8080277
   Rajanikant GK, 2007, STROKE, V38, P3023, DOI 10.1161/STROKEAHA.107.488502
   Roman A, 2013, PHARMACOL REP, V65, P1663, DOI 10.1016/S1734-1140(13)71528-7
   Schön M, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061196
   Seminara AR, 2007, CELL CYCLE, V6, P1772, DOI 10.4161/cc.6.14.4438
   Shaftel SS, 2008, J NEUROINFLAMM, V5, DOI 10.1186/1742-2094-5-7
   SHULL MM, 1992, NATURE, V359, P693, DOI 10.1038/359693a0
   Singel KL, 2016, CLIN SCI, V130, P479, DOI 10.1042/CS20150660
   Srisook K, 2005, METHOD ENZYMOL, V396, P414, DOI 10.1016/S0076-6879(05)96035-7
   Steiner MK, 2009, CIRC RES, V104, P236, DOI 10.1161/CIRCRESAHA.108.182014
   Szczurek W, 2015, KARDIOCHIR TORAKOCHI, V12, P145, DOI 10.5114/kitp.2015.52856
   Takahashi F, 2000, IUBMB LIFE, V49, P217, DOI 10.1080/713803614
   Tataranni T, 2017, ONCOTARGET, V8, P41265, DOI 10.18632/oncotarget.17172
   Terry AV, 2003, J PHARMACOL EXP THER, V306, P821, DOI 10.1124/jpet.102.041616
   Tibullo D, 2016, ONCOTARGET, V7, P28868, DOI 10.18632/oncotarget.7563
   Torrisi SA, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.00693
   Vanella L, 2016, ONCOTARGET, V7, P69075, DOI 10.18632/oncotarget.11923
   Vijayan V, 2019, REDOX BIOL, V22, DOI 10.1016/j.redox.2019.101147
   Vijayan V, 2018, BIOCHEM PHARMACOL, V153, P159, DOI 10.1016/j.bcp.2018.02.010
   WINNICK RE, 1959, BIOCHIM BIOPHYS ACTA, V31, P47, DOI 10.1016/0006-3002(59)90437-8
   Zhang XM, 2011, EUR J PHARMACOL, V667, P202, DOI 10.1016/j.ejphar.2011.06.003
NR 92
TC 75
Z9 76
U1 0
U2 22
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB
PY 2020
VL 21
IS 3
AR 776
DI 10.3390/ijms21030776
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA KY4PQ
UT WOS:000522551601045
PM 31991717
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wang, XY
   Zhang, HP
   Zhang, PF
   Hao, SL
   Yang, X
   Zhou, X
AF Wang, Xiangyu
   Zhang, Huaping
   Zhang, Pengfu
   Hao, Shulan
   Yang, Xi
   Zhou, Xin
TI Clinical investigation of lipopolysaccharide in the persistence of
   metabolic syndrome (MS) through the activation of GRP78-IRE1α-ASK1
   signaling pathway
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Lipopolysaccharide (LPS); Endoplasmic reticulum (ER) stress;
   Inflammation; Insulin resistance
ID ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE; GUT MICROBIOTA;
   INFLAMMATION; OBESITY; PATHOGENESIS
AB Objective Endoplasmic reticulum stress (ERS) might play a pivotal role in the persistence of metabolic syndrome (MS). Lipopolysaccharide (LPS) derived from various gram-negative bacteria could result in the ERS. Therefore, we aimed to investigate the association between LPS and ERS in MS. Method We enrolled 86 patients with MS and 42 healthy people aged 35-65 years. Body weight, waist circumference, blood pressure were measured. LPS, LBP and inflammation factors, fasting plasma glucose (FPG), insulin, total cholesterol (TC), triglyceride, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), free fatty acid (FFA) were analyzed in blood plasma of patient's cohort. Body mass index (BMI) and HOMA-IR were calculated. The mRNA and protein expression of ERS GRP78, IRE1 alpha, ASK1 and IKK beta, JNK1 were measured in blood plasma of patient's cohort by RT-PCR and Elisa. MS was defined by the updated National Cholesterol Education Program Adult Treatment Panel III criterion for Asian Americans. Results BMI, waist circumference, blood pressure, FPG, insulin, HOMA-IR, TC, triglyceride, HDL-C, LDL-C, FFA and LPS, LBP, TNF-alpha, CRP, IL-1, IL-6, MCP-1 were significantly higher in patients with MS than healthy people (P < 0.001). The correlation analysis suggested that LPS were associated with TNF-alpha, IL-1, IL-6, MCP-1, LBP, FFA, HOMA-IR potently (P < 0.05). The marker gene and protein expressions of ERS (GRP78, IRE1 alpha, ASK1, IKK beta and JNK) were significantly overexpressed in patients with MS and were positive correlation with LPS (P < 0.05). Conclusion LPS may play an important role in mediating chronic low-grade inflammation by activating the ERS GRP78-IRE1 alpha-ASK1 signaling pathway, contributing to the persistence of MS.
C1 [Yang, Xi] Shanxi Prov Res Inst Tradit Chinese Med, Dept Oncol, Taiyuan 030012, Peoples R China.
   [Zhang, Huaping; Zhou, Xin] Shanxi Med Univ, Dept Pathophysiol, Basic Med Sci, 52 Xin Jian South Rd, Taiyuan 030001, Peoples R China.
   [Wang, Xiangyu; Zhang, Pengfu; Hao, Shulan] Shanxi Med Univ, Shanxi Prov Key Lab Oral Dis Prevent & New Mat, Sch & Hosp Stomatol, Taiyuan 030001, Peoples R China.
C3 Shanxi Medical University; Shanxi Medical University
RP Yang, X (corresponding author), Shanxi Prov Res Inst Tradit Chinese Med, Dept Oncol, Taiyuan 030012, Peoples R China.; Zhou, X (corresponding author), Shanxi Med Univ, Dept Pathophysiol, Basic Med Sci, 52 Xin Jian South Rd, Taiyuan 030001, Peoples R China.
EM Susieyx0824@126.com; xinxin6633@yeah.net
RI zhang, huaping/KQU-3923-2024
FU Natural Science Foundation of Shanxi Province, China [201801D221387,
   201901D111196]; Shanxi Scholarship Council of China [2020-074]; 2020
   Shanxi Province Graduate Education Reform (mandatory) research project
   China [2020YJJG135]; Follow-up to the Fourth National Oral Health
   Epidemiological Survey [201502002]; Chinese Stomatological Association,
   China
FX This study was funded by the Natural Science Foundation of Shanxi
   Province, China [No. 201801D221387], the Natural Science Foundation of
   Shanxi Province, China [No. 201901D111196], Shanxi Scholarship Council
   of China [No. 2020-074] and 2020 Shanxi Province Graduate Education
   Reform (mandatory) research project China [No. 2020YJJG135], Follow-up
   to the Fourth National Oral Health Epidemiological Survey [No.
   201502002], Chinese Stomatological Association, China.
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
   Amen OM, 2019, FRONT PHARMACOL, V10, DOI 10.3389/fphar.2019.00977
   Amin MN, 2019, DIABETES METAB SYND, V13, P1213, DOI 10.1016/j.dsx.2019.01.041
   Asrih M, 2015, MOL CELL ENDOCRINOL, V418, P55, DOI 10.1016/j.mce.2015.02.018
   Berlanga-Acosta J, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.560375
   Chaudhari N, 2014, FRONT CELL NEUROSCI, V8, DOI 10.3389/fncel.2014.00213
   Chovatiya R, 2014, MOL CELL, V54, P281, DOI 10.1016/j.molcel.2014.03.030
   Ferraz-Bannitz R, 2021, DIABETOL METAB SYNDR, V13, DOI 10.1186/s13098-021-00623-w
   Fuke N, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102277
   Gomes JMG, 2017, METABOLISM, V68, P133, DOI 10.1016/j.metabol.2016.12.009
   Gluvic Z, 2017, CURR VASC PHARMACOL, V15, P30, DOI 10.2174/1570161114666161007164510
   Heo YJ, 2019, J DIABETES RES, V2019, DOI 10.1155/2019/4021623
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   Issa N, 2018, J LIPID RES, V59, P2321, DOI 10.1194/jlr.M086504
   Ji Y, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21093066
   Kahn CR, 2019, J CLIN INVEST, V129, P3990, DOI 10.1172/JCI129187
   Karczewski J, 2018, EUR CYTOKINE NETW, V29, P83, DOI 10.1684/ecn.2018.0415
   Liang B, 2020, MEDIAT INFLAMM, V2020, DOI 10.1155/2020/5287108
   Lu ZY, 2017, ATHEROSCLEROSIS, V265, P231, DOI 10.1016/j.atherosclerosis.2017.09.008
   Mangali S, 2019, J CELL BIOCHEM, V120, P3651, DOI 10.1002/jcb.27643
   Negi H, 2016, BIOCHEM BIOPH RES CO, V480, P539, DOI 10.1016/j.bbrc.2016.10.073
   Oakes SA, 2015, ANNU REV PATHOL-MECH, V10, P173, DOI 10.1146/annurev-pathol-012513-104649
   Onyango AN, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/4321714
   Saad MJA, 2016, PHYSIOLOGY, V31, P283, DOI 10.1152/physiol.00041.2015
   Samuel VT, 2016, J CLIN INVEST, V126, P12, DOI 10.1172/JCI77812
   Solinas G, 2017, MOL METAB, V6, DOI 10.1016/j.molmet.2016.12.001
   Tilg H, 2020, NAT REV IMMUNOL, V20, P40, DOI 10.1038/s41577-019-0198-4
   Tirosh A, 2021, CELL METAB, V33, P319, DOI 10.1016/j.cmet.2020.11.009
   Wu HZ, 2020, CIRC RES, V126, P1549, DOI 10.1161/CIRCRESAHA.119.315896
   Wu YL, 2018, BIOMED PHARMACOTHER, V97, P1673, DOI 10.1016/j.biopha.2017.12.024
   Xiao SM, 2014, FEMS MICROBIOL ECOL, V87, P357, DOI 10.1111/1574-6941.12228
   Yang DH, 2021, J CELL PHYSIOL, V236, P3536, DOI 10.1002/jcp.30088
   Yang M., 2020, BMC COMPLEMENT MED, V20, P1, DOI [10.1186/s12906-019-2780-5, DOI 10.1186/S12906-019-2780-5]
   Yi SY, 2019, FRONT CELL NEUROSCI, V13, DOI 10.3389/fncel.2019.00190
   Yi XQ, 2020, MOL MED REP, V21, P2041, DOI 10.3892/mmr.2020.11013
   Yuan JH, 2021, J DIABETES COMPLICAT, V35, DOI 10.1016/j.jdiacomp.2020.107766
   Zand H, 2017, DIABETES METAB SYND, V11, pS307, DOI 10.1016/j.dsx.2017.03.006
   Zhang KZ, 2008, NATURE, V454, P455, DOI 10.1038/nature07203
   Zhang Y, 2019, ANTIMICROB AGENTS CH, V63, DOI [10.1128/AAC.01639-18, 10.1128/aac.01639-18]
NR 39
TC 1
Z9 1
U1 0
U2 3
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD FEB
PY 2022
VL 477
IS 2
BP 585
EP 592
DI 10.1007/s11010-021-04302-2
EA NOV 2021
PG 8
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA YQ3NZ
UT WOS:000723988200002
PM 34850317
DA 2025-06-11
ER

PT J
AU Radice, RP
   Limongi, AR
   Viviano, E
   Padula, MC
   Martelli, G
   Bermano, G
AF Radice, Rosa Paola
   Limongi, Antonina Rita
   Viviano, Emanuele
   Padula, Maria Carmela
   Martelli, Giuseppe
   Bermano, Giovanna
TI Effects of astaxanthin in animal models of obesity-associated diseases:
   A systematic review and meta-analysis
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Review
DE Astaxanthin; Meta-analysis; Metabolic syndrome; Non-alcoholic fatty
   liver disease; Obesity; Type 2 diabetes
ID DIET-INDUCED OBESITY; LOWERS BLOOD-PRESSURE; OXIDATIVE STRESS;
   HAEMATOCOCCUS-PLUVIALIS; ADIPOSE-TISSUE; ENDOPLASMIC-RETICULUM; INSULIN
   SENSITIVITY; PPAR-GAMMA; INFLAMMATION; MICE
AB Background and aim: Obesity is a major risk factor for several diseases, including metabolic syndrome (MetS), non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D). The use of natural products, such as astaxanthin (ASX), a potent antioxidant compound produced by the freshwater green microalga Haematococcus pluvialis, has gained particular interest to reduce oxidative stress and inflammation, and to improve redox status, often associated with obesity. A systematic review and meta-analysis was performed to comprehensively examine the effects of ASX in animal models of diet induced obesity-associated diseases in order to inform the design of future human clinical studies for ASX use as supplement or nutraceutical.
   Methods: Cinahl, Cochraine, MEDLINE, Scopus and Web of Science were searched for English-language manuscripts published between January 2000 and April 2020 using the following key words: astaxanthin, obesity, non-alcoholic fatty liver disease, diabetes mellitus type 2, NAFLD and metabolic.
   Results: Seventeen eligible articles, corresponding to 21 animal studies, were included in the final quantitative analysis. ASX, at different concentrations and administered for different length of time, induced a significant reduction in adipose tissue weight (P = 0.05) and systolic blood pressure (P < 0.0001) in control animals. In animal models of T2D, ASX significantly reduced serum glucose levels (P = 0.04); whereas it improved several disease biomarkers in the blood (e.g. cholesterol, triglycerides, ALT and AST, P < 0.10), and reduced liver (P = 0.0002) and body weight (P = 0.11), in animal models of NAFLD.
   Conclusions: Supplementation of ASX in the diet has positive effects on symptoms associated with obesity related diseases in animals, by having lipid-lowering, hypo-insulin and hypoglycaemic capacity, protecting organs from oxidative stress and mitigating the immune system, as suggested in this review.
C1 [Radice, Rosa Paola; Limongi, Antonina Rita; Viviano, Emanuele; Padula, Maria Carmela; Martelli, Giuseppe] Univ Basilicata, Dept Sci, Potenza, Italy.
   [Radice, Rosa Paola; Limongi, Antonina Rita] Bioinnova Srls, Via Ponte Nove Luci, Potenza, Italy.
   [Padula, Maria Carmela] San Carlo Hosp Potenza, Rheumatol Inst Lucania IReL, Rheumatol Dept Lucania, Potenza, Italy.
   [Padula, Maria Carmela] Madonna delle Grazie Hosp Matera, Potenza, Italy.
   [Bermano, Giovanna] Robert Gordon Univ, Sch Pharm & Life Sci, Ctr Obes Res & Educ CORE, Sir Ian Wood Bldg,Garthdee Rd, Aberdeen AB10 7GJ, Scotland.
C3 Italfarmaco; University of Basilicata; Robert Gordon University
RP Bermano, G (corresponding author), Robert Gordon Univ, Sch Pharm & Life Sci, Ctr Obes Res & Educ CORE, Sir Ian Wood Bldg,Garthdee Rd, Aberdeen AB10 7GJ, Scotland.
EM g.bermano@rgu.ac.uk
RI Limongi, Antonina Rita/AAZ-9422-2021; Radice, Rosa Paola/AFJ-7984-2022;
   Viviano, Emanuele/IST-7926-2023; Padula, Maria/S-8285-2019
OI Viviano, Emanuele/0000-0001-8264-5205; Radice, Rosa
   Paola/0000-0002-5043-8313; , Antonina Rita Limongi/0000-0003-1570-8370;
   Bermano, Giovanna/0000-0001-6027-6437
FU University of Basilicata
FX RPR was supported by a fellowship under the Erasmus Traineeship Program
   from the University of Basilicata during her stay in Aberdeen.
CR Arunkumar E, 2012, FOOD FUNCT, V3, P120, DOI 10.1039/c1fo10161g
   Bhuvaneswari S, 2014, CELL STRESS CHAPERON, V19, P183, DOI 10.1007/s12192-013-0443-x
   Bhuvaneswari S, 2010, PROCESS BIOCHEM, V45, P1406, DOI 10.1016/j.procbio.2010.05.016
   Boutens L, 2016, DIABETOLOGIA, V59, P879, DOI 10.1007/s00125-016-3904-9
   Chan KC, 2019, J FUNCT FOODS, V53, P22, DOI 10.1016/j.jff.2018.12.012
   Chen YY, 2020, N-S ARCH PHARMACOL, V393, P2517, DOI 10.1007/s00210-020-01861-x
   Chen Z, 2020, FREE RADICAL BIO MED, V152, P116, DOI 10.1016/j.freeradbiomed.2020.02.025
   Choi HD, 2011, PLANT FOOD HUM NUTR, V66, P363, DOI 10.1007/s11130-011-0258-9
   Choi HD, 2011, BRIT J NUTR, V105, P220, DOI 10.1017/S0007114510003454
   Choi SA, 2019, BIORESOURCE TECHNOL, V274, P120, DOI 10.1016/j.biortech.2018.11.082
   Chou HY, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/4946902
   Davinelli S, 2018, NUTRIENTS, V10, DOI 10.3390/nu10040522
   Dinarello CA, 2002, CLIN EXP RHEUMATOL, V20, pS1
   Egger M, 1997, BMJ-BRIT MED J, V315, P629, DOI 10.1136/bmj.315.7109.629
   Figueira TR, 2013, ANTIOXID REDOX SIGN, V18, P2029, DOI 10.1089/ars.2012.4729
   Gao Y, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21062149
   Gregor MF, 2007, J LIPID RES, V48, P1905, DOI 10.1194/jlr.R700007-JLR200
   Guerin M, 2003, TRENDS BIOTECHNOL, V21, P210, DOI 10.1016/S0167-7799(03)00078-7
   Harford KA, 2011, P NUTR SOC, V70, P408, DOI 10.1017/S0029665111000565
   Hooijmans CR, 2014, BMC MED RES METHODOL, V14, DOI 10.1186/1471-2288-14-43
   Hormozi M, 2019, ARTIF CELL NANOMED B, V47, P891, DOI 10.1080/21691401.2019.1580286
   Hwang SW, 2019, BIORESOURCE TECHNOL, V278, P138, DOI 10.1016/j.biortech.2019.01.080
   Ikeuchi M, 2007, BIOSCI BIOTECH BIOCH, V71, P893, DOI 10.1271/bbb.60521
   Inoguchi T, 2005, CURR DRUG TARGETS, V6, P495, DOI 10.2174/1389450054021927
   Jia Y, 2016, J NUTR BIOCHEM, V28, P9, DOI [10.20463/jenb.2016.0055, 10.1016/j.jnutbio.2015.09.015]
   Jones JR, 2005, P NATL ACAD SCI USA, V102, P6207, DOI 10.1073/pnas.0306743102
   Kim B, 2017, J NUTR BIOCHEM, V43, P27, DOI 10.1016/j.jnutbio.2016.01.006
   Kimura M, 2014, J FUNCT FOODS, V11, P114, DOI 10.1016/j.jff.2014.08.001
   Kobori M, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18030593
   Kumar SR, 2016, MOL CELL BIOCHEM, V417, P57, DOI 10.1007/s11010-016-2713-2
   Lechuga-Sancho AM, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0191547
   Liu R, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.01587
   Liu Y, 2008, DIABETES, V57, P777, DOI 10.2337/db07-0008
   Locksley RM, 2001, CELL, V104, P487, DOI 10.1016/S0092-8674(01)00237-9
   Lord GM, 1998, NATURE, V394, P897, DOI 10.1038/29795
   Bonet ML, 2016, SUBCELL BIOCHEM, V79, P377, DOI 10.1007/978-3-319-39126-7_15
   Martínez JM, 2019, BIORESOURCE TECHNOL, V289, DOI 10.1016/j.biortech.2019.121694
   Mashhadi NS, 2018, ASIA PAC J CLIN NUTR, V27, P341, DOI 10.6133/apjcn.052017.11
   Maslov LN, 2019, J CLIN TRANSL ENDOCR, V15, P1, DOI 10.1016/j.jcte.2018.11.001
   Mason SA, 2020, REDOX BIOL, V35, DOI 10.1016/j.redox.2020.101471
   Mishra J, 2015, J BIOL CHEM, V290, P29301, DOI 10.1074/jbc.M115.670331
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Ni YH, 2015, SCI REP-UK, V5, DOI 10.1038/srep17192
   Nishida Y, 2020, J CACHEXIA SARCOPENI, V11, P241, DOI 10.1002/jcsm.12530
   Odeberg JM, 2003, EUR J PHARM SCI, V19, P299, DOI 10.1016/S0928-0987(03)00135-0
   Olokoba Abdulfatai B, 2012, Oman Med J, V27, P269, DOI 10.5001/omj.2012.68
   Osterlie M, 2000, J NUTR BIOCHEM, V11, P482, DOI 10.1016/S0955-2863(00)00104-2
   Piantadosi CA, 2011, J BIOL CHEM, V286, DOI 10.1074/jbc.M110.207738
   Picu A, 2017, MOLECULES, V22, DOI 10.3390/molecules22050714
   Preuss HG, 2011, INT J MED SCI, V8, P126, DOI 10.7150/ijms.8.126
   Preuss HG, 2009, J FUNCT FOODS, V1, P13, DOI 10.1016/j.jff.2008.09.001
   Satoh A, 2009, J CLIN BIOCHEM NUTR, V44, P280, DOI 10.3164/jcbn.08-238
   Spitaler MM, 2002, DIABETOLOGIA, V45, P476, DOI 10.1007/s00125-002-0782-0
   Sureda A., 2020, ANTIOXIDANTS-BASEL, V9
   Talior I, 2003, AM J PHYSIOL-ENDOC M, V285, pE295, DOI 10.1152/ajpendo.00044.2003
   Tu BP, 2004, J CELL BIOL, V164, P341, DOI 10.1083/jcb.200311055
   Uchiyama K, 2002, REDOX REP, V7, P290, DOI 10.1179/135100002125000811
   Vona R, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8267234
   Wolf J, 2014, CYTOKINE, V70, P11, DOI 10.1016/j.cyto.2014.05.024
   World Health Organization, 2019, Patient Safety
   Wright E, 2006, INT J CLIN PRACT, V60, P308, DOI 10.1111/j.1368-5031.2006.00825.x
   Xu HY, 2003, J CLIN INVEST, V112, P1821, DOI 10.1172/JCI200319451
   Yang Y, 2014, BRIT J NUTR, V112, P1797, DOI 10.1017/S0007114514002554
   Zafar U, 2018, HORM-INT J ENDOCRINO, V17, P299, DOI 10.1007/s42000-018-0051-3
NR 64
TC 21
Z9 23
U1 4
U2 28
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD AUG 1
PY 2021
VL 171
BP 156
EP 168
DI 10.1016/j.freeradbiomed.2021.05.008
EA MAY 2021
PG 13
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA SV2VS
UT WOS:000663682800001
PM 33974978
OA Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Park, YM
   Lee, HJ
   Kang, SG
   Choi, JE
   Cho, JH
   Kim, L
AF Park, Young-Min
   Lee, Heon-Jeong
   Kang, Seung-Gul
   Choi, Jung-Eun
   Cho, Jae-Hyuck
   Kim, Leen
TI Lack of Association between Glutathione S-Transferase-M1,-T1, and-P1
   Polymorphisms and Olanzapine-Induced Weight Gain in Korean Schizophrenic
   Patients
SO PSYCHIATRY INVESTIGATION
LA English
DT Article
DE Weight gain; Olanzapine; Polymorphism; Glutathione-S-transferase
ID MULTIFACTOR-DIMENSIONALITY REDUCTION; GENE-GENE INTERACTIONS;
   QUALITY-OF-LIFE; INSULIN-RESISTANCE; ANTIPSYCHOTIC MEDICATIONS; ATYPICAL
   ANTIPSYCHOTICS; MULTIPLE-SCLEROSIS; TARDIVE-DYSKINESIA; METABOLIC
   SYNDROME; OXIDATIVE STRESS
AB Objective Oxidative stress may be an important pathogenic mechanism in the obesity and metabolic syndrome. The aims of this study was to assess the possible association between the oxidative stress related Glutathione S-Transferase genes (GST-M1, GST-T1, and GST-P1) variants and the olanzapine-induced weight gain in Korean schizophrenic patients.
   Methods We categorized 78 schizophrenic patients into two groups the more than 7% weight gain from baseline (weight gain >= 7%) and the less weight gain (weight gain <7%) groups according to weight change between before and after long-term olanzapine treatment (440 +/- 288 days). All participants were genotyped for the GST-M1, GST-T1 and GST-P1 genes. Differences in allele frequencies between cohorts with different body weight changes were evaluated by a chi-square analysis and Fisher's exact test. The multifactor dimensionality reduction (MDR) approach was used to analyze gene-gene interactions.
   Results Mean body weight gain was 5.42 kg. There was no difference in the null genotype distribution of GST-M1 and -T1 between subjects with body weight gain >= 7% compared to subjects with body weight gain <7% (p>0.05). No significant difference in GST-P1 genotype and allele frequencies were observed between the groups (p>0.05). MDR analysis did not show a significant interaction between the three GST gene variants and susceptibility to weight gain (p>0.05).
   Conclusion These findings do not support a relationship between the genetic variants of three GST genes (GST-M1, -T1 and -P1) and weight gain in Korean schizophrenic patients receiving olanzapine treatment. Psychiatry Investig 2010;7:147-152
C1 [Lee, Heon-Jeong; Kang, Seung-Gul; Choi, Jung-Eun; Kim, Leen] Korea Univ, Coll Med, Dept Psychiat, Seoul 136705, South Korea.
   [Park, Young-Min; Cho, Jae-Hyuck] Inje Univ, Coll Med, Ilsan Paik Hosp, Dept Neuropsychiat, Goyang, South Korea.
   [Lee, Heon-Jeong; Choi, Jung-Eun] Korea Univ, Coll Med, Div Brain Korea Biomed Sci 21, Seoul 136705, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine); Inje
   University; Korea University; Korea University Medicine (KU Medicine)
RP Lee, HJ (corresponding author), Korea Univ, Coll Med, Dept Psychiat, 126-1 Anam Dong 5 Ga, Seoul 136705, South Korea.
EM leehjeong@korea.ac.kr
RI ; Lee, Heon-Jeong/K-5871-2015
OI Kang, Seung-Gul/0000-0003-4933-0433; Lee, Heon-Jeong/0000-0002-9560-2383
FU Korean Government [KRF-2008-313-E00333]; Inje University
FX This work was supported by the Korea Research Foundation Grant funded by
   the Korean Government (KRF-2008-313-E00333). PYM was supported by a 2008
   Inje University research grant.
CR Agirbasli D, 2006, CORONARY ARTERY DIS, V17, P413, DOI 10.1097/00019501-200608000-00003
   Allison DB, 2003, PSYCHIAT SERV, V54, P565, DOI 10.1176/appi.ps.54.4.565
   Allison DB, 1999, AM J PSYCHIAT, V156, P1686
   Andreassen OA, 2000, PROG NEUROBIOL, V61, P525, DOI 10.1016/S0301-0082(99)00064-7
   [Anonymous], 2000, STRUCTURED CLIN INTE
   Brassat D, 2006, GENES IMMUN, V7, P310, DOI 10.1038/sj.gene.6364299
   Casey DE, 2001, J CLIN PSYCHIAT, V62, P4
   Eriksson JW, 2007, FEBS LETT, V581, P3734, DOI 10.1016/j.febslet.2007.06.044
   Fridlyand LE, 2006, DIABETES OBES METAB, V8, P136, DOI 10.1111/j.1463-1326.2005.00496.x
   Hahn LW, 2003, BIOINFORMATICS, V19, P376, DOI 10.1093/bioinformatics/btf869
   Hayes JD, 2000, PHARMACOLOGY, V61, P154, DOI 10.1159/000028396
   Houstis N, 2006, NATURE, V440, P944, DOI 10.1038/nature04634
   Hsieh CH, 2006, HUM MOL GENET, V15, P2701, DOI 10.1093/hmg/ddl203
   Jibson MD, 1998, J PSYCHIAT RES, V32, P215, DOI 10.1016/S0022-3956(98)00023-5
   Kang J, 2008, CELL BIOL INT, V32, P163, DOI 10.1016/j.cellbi.2007.07.001
   Kang SG, 2009, HUM PSYCHOPHARM CLIN, V24, P55, DOI 10.1002/hup.988
   Kuzuya M, 2008, AM J CLIN NUTR, V87, P1939, DOI 10.1093/ajcn/87.6.1939
   Lee YS, 2008, MOL ENDOCRINOL, V22, P2176, DOI 10.1210/me.2008-0023
   Mannervik B, 1985, Adv Enzymol Relat Areas Mol Biol, V57, P357
   Motsinger AA, 2006, GENET EPIDEMIOL, V30, P546, DOI 10.1002/gepi.20166
   Motsinger AA, 2007, NEUROGENETICS, V8, P11, DOI 10.1007/s10048-006-0058-9
   Nasrallah H, 2003, PSYCHONEUROENDOCRINO, V28, P83, DOI 10.1016/S0306-4530(02)00114-2
   Packer L, 2001, NUTRITION, V17, P888, DOI 10.1016/S0899-9007(01)00658-X
   Palmieri VO, 2006, J NUTR, V136, P3022, DOI 10.1093/jn/136.12.3022
   Park YM, 2008, J CLIN PHARM THER, V33, P55, DOI 10.1111/j.1365-2710.2008.00872.x
   Park YM, 2006, AM J MED GENET B, V141B, P394, DOI 10.1002/ajmg.b.30311
   Park YM, 2009, PSYCHIAT INVEST, V6, P39, DOI 10.4306/pi.2009.6.1.39
   PEMBLE S, 1994, BIOCHEM J, V300, P271, DOI 10.1042/bj3000271
   Perkins DO, 1999, J CLIN PSYCHIAT, V60, P25
   Pillai A, 2007, J PSYCHIATR RES, V41, P372, DOI 10.1016/j.jpsychires.2006.01.011
   Ritchie MD, 2001, AM J HUM GENET, V69, P138, DOI 10.1086/321276
   Ritchie MD, 2003, GENET EPIDEMIOL, V24, P150, DOI 10.1002/gepi.10218
   Rösen P, 2001, DIABETES-METAB RES, V17, P189, DOI 10.1002/dmrr.196
   Ryu S, 2007, PROG NEURO-PSYCHOPH, V31, P673, DOI 10.1016/j.pnpbp.2006.12.021
   Sagara Y, 1998, J NEUROCHEM, V71, P1002, DOI 10.1046/j.1471-4159.1998.71031002.x
   SEIDEGARD J, 1990, CARCINOGENESIS, V11, P33, DOI 10.1093/carcin/11.1.33
   Silva MD, 2004, ENVIRON MOL MUTAGEN, V43, P258, DOI 10.1002/em.20015
   Strassnig M, 2003, SCHIZOPHR RES, V62, P73, DOI 10.1016/S0920-9964(02)00441-3
   Sundberg K, 1998, CARCINOGENESIS, V19, P433, DOI 10.1093/carcin/19.3.433
   Taylor DM, 2000, ACTA PSYCHIAT SCAND, V101, P416, DOI 10.1034/j.1600-0447.2000.101006416.x
   Vauth R, 2004, PSYCHIAT RES, V126, P43, DOI 10.1016/j.psychres.2003.07.004
   Velez DR, 2007, GENET EPIDEMIOL, V31, P306, DOI 10.1002/gepi.20211
   Walss-Bass C, 2008, INT J NEUROPSYCHOPH, V11, P1097, DOI 10.1017/S1461145708008882
   Zhong SL, 2006, EUR J PHARM SCI, V28, P77, DOI 10.1016/j.ejps.2006.01.002
NR 44
TC 5
Z9 6
U1 0
U2 2
PU KOREAN NEUROPSYCHIATRIC ASSOC
PI SEOUL
PA RN 522, G-FIVE CENTRAL PLAZA 1685-8 SEOCHO 4-DONG, SEOCHO-GU, SEOUL,
   137-882, SOUTH KOREA
SN 1738-3684
EI 1976-3026
J9 PSYCHIAT INVEST
JI Psychiatry Investig.
PD JUN
PY 2010
VL 7
IS 2
BP 147
EP 152
DI 10.4306/pi.2010.7.2.147
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA 614PN
UT WOS:000279072300011
PM 20577625
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Abraham, SB
   Rubino, D
   Sinaii, N
   Ramsey, S
   Nieman, LK
AF Abraham, S. B.
   Rubino, D.
   Sinaii, N.
   Ramsey, S.
   Nieman, L. K.
TI Cortisol, Obesity, and the Metabolic Syndrome: A Cross-Sectional Study
   of Obese Subjects and Review of the Literature
SO OBESITY
LA English
DT Review
ID PITUITARY-ADRENAL AXIS; BODY-FAT DISTRIBUTION; PLASMA-CORTISOL;
   CARDIOVASCULAR RISK; INSULIN-RESISTANCE; PRODUCTION-RATES;
   BLOOD-PRESSURE; HEART-DISEASE; WOMEN; MEN
AB Objective: Circulating cortisol and psychosocial stress may contribute to the pathogenesis of obesity and metabolic syndrome (MS). To evaluate these relationships, a cross-sectional study of 369 overweight and obese subjects and 60 healthy volunteers was performed and reviewed the previous literature.
   Design and Methods: Overweight and obese subjects had at least two other features of Cushing's syndrome. They underwent measurements representing cortisol dynamics (24 h urine cortisol excretion (UFC), bedtime salivary cortisol, 1 mg dexamethasone suppression test) and metabolic parameters (BMI, blood pressure (BP); fasting serum triglycerides, HDL, insulin, and glucose). Subjects also completed the Perceived Stress Scale (PSS). UFC, salivary cortisol, and weight from 60 healthy volunteers were analyzed.
   Results: No subject had Cushing's syndrome. UFC and dexamethasone responses were not associated with BMI or weight. However, salivary cortisol showed a trend to increase as BMI increased (P < 0.0001), and correlated with waist circumference (WC) in men (r(s) = 0.28, P = 0.02) and systolic BP in women (r(s) = 0.24, P = 0.0008). Post-dexamethasone cortisol levels were weak to moderately correlated with fasting insulin (r(s) = -0.31, P = 0.01) and HOMA-IR (r(s) = -0.31, P = 0.01) in men and systolic (r(s) = 0.18, P = 0.02) and diastolic BP (r(s) = 0.20, P = 0.009) in women. PSS results were higher in obese subjects than controls, but were not associated with cortisol or metabolic parameters. As expected, WC correlated with fasting insulin, HOMA-IR, and systolic BP (adjusted for BMI and gender; P < 0.01). Literature showed inconsistent relationships between cortisol and metabolic parameters.
   Conclusion: Taken together, these data do not support a strong relationship between systemic cortisol or stress and obesity or MS.
C1 [Abraham, S. B.; Nieman, L. K.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD USA.
   [Rubino, D.; Ramsey, S.] Washington Ctr Weight Management & Res, Arlington, VA USA.
   [Rubino, D.; Ramsey, S.] George Washington Univ, Weight Management Program, Washington, DC USA.
   [Sinaii, N.] NIH, Biostat & Clin Epidemiol Serv, Ctr Clin, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver
   National Institute of Child Health & Human Development (NICHD); George
   Washington University; National Institutes of Health (NIH) - USA; NIH
   Clinical Center (CC)
RP Rubino, D (corresponding author), Washington Ctr Weight Management & Res, Arlington, VA USA.
EM drubino@wtmgmt.com
OI Rubino, Domenica/0000-0002-3072-2819; Nieman,
   Lynnette/0000-0003-0534-8025
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development, National Institutes of Health
FX This work was supported in part by the intramural program of The Eunice
   Kennedy Shriver National Institute of Child Health and Human
   Development, National Institutes of Health.
CR Anagnostis P, 2009, J CLIN ENDOCR METAB, V94, P2692, DOI 10.1210/jc.2009-0370
   Andrew R, 1998, J CLIN ENDOCR METAB, V83, P1806, DOI 10.1210/jc.83.5.1806
   [Anonymous], 2010, FTC TARG PROD CLAIM
   Baid SK, 2007, J CLIN ENDOCR METAB, V92, P3102, DOI 10.1210/jc.2006-2861
   Baid SK, 2009, J CLIN ENDOCR METAB, V94, P3857, DOI 10.1210/jc.2008-2766
   Brunner EJ, 2007, AM J EPIDEMIOL, V165, P828, DOI 10.1093/aje/kwk058
   Chandola T, 2008, EUR HEART J, V29, P640, DOI 10.1093/eurheartj/ehm584
   COHEN S, 1983, J HEALTH SOC BEHAV, V24, P385, DOI 10.2307/2136404
   Duclos M, 2005, OBES RES, V13, P1157, DOI 10.1038/oby.2005.137
   Duclos M, 2001, CLIN ENDOCRINOL, V55, P447, DOI 10.1046/j.1365-2265.2001.01384.x
   Filipovsky J, 1996, J HYPERTENS, V14, P229, DOI 10.1097/00004872-199602000-00012
   Flegal KM, 2007, JAMA-J AM MED ASSOC, V298, P2028, DOI 10.1001/jama.298.17.2028
   Genuth S, 2003, DIABETES CARE, V26, P3160
   Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67
   Ketteler J, 2008, WOMENS HLTH
   Ljung T, 1996, OBES RES, V4, P277, DOI 10.1002/j.1550-8528.1996.tb00546.x
   Maggio M, 2006, J AM GERIATR SOC, V54, P1832, DOI 10.1111/j.1532-5415.2006.00963.x
   MARIN P, 1992, METABOLISM, V41, P882, DOI 10.1016/0026-0495(92)90171-6
   Oltmanns KM, 2006, EUR J ENDOCRINOL, V154, P325, DOI 10.1530/eje.1.02074
   Pasquali R, 1996, METABOLISM, V45, P351, DOI 10.1016/S0026-0495(96)90290-5
   PASQUALI R, 1993, J CLIN ENDOCR METAB, V77, P341, DOI 10.1210/jc.77.2.341
   Pasquali R, 2002, J CLIN ENDOCR METAB, V87, P166, DOI 10.1210/jc.87.1.166
   Phillips DIW, 1998, J CLIN ENDOCR METAB, V83, P757, DOI 10.1210/jc.83.3.757
   Pivonello R, 2005, ENDOCRIN METAB CLIN, V34, P327, DOI 10.1016/j.ecl.2005.01.010
   Poirier P, 2005, HYPERTENSION, V45, P363, DOI 10.1161/01.HYP.0000155463.90018.dc
   Purnell JQ, 2009, AM J PHYSIOL-ENDOC M, V296, pE351, DOI 10.1152/ajpendo.90769.2008
   Purnell JQ, 2004, J CLIN ENDOCR METAB, V89, P281, DOI 10.1210/jc.2003-030440
   Räikkönen K, 2002, METABOLISM, V51, P1573, DOI 10.1053/meta.2002.36301
   Rask E, 2001, J CLIN ENDOCR METAB, V86, P1418, DOI 10.1210/jc.86.3.1418
   Reynolds RM, 2010, J CLIN ENDOCR METAB, V95, P1602, DOI 10.1210/jc.2009-2112
   Steptoe A, 2004, INT J OBESITY, V28, P1168, DOI 10.1038/sj.ijo.0802715
   Stewart PM, 1999, J CLIN ENDOCR METAB, V84, P1022, DOI 10.1210/jc.84.3.1022
   Stolk RP, 1996, J ENDOCRINOL, V149, P313, DOI 10.1677/joe.0.1490313
   STRAIN GW, 1982, METABOLISM, V31, P209, DOI 10.1016/0026-0495(82)90054-3
   STRAIN GW, 1980, METABOLISM, V29, P980, DOI 10.1016/0026-0495(80)90043-8
   Travison TG, 2007, CLIN ENDOCRINOL, V67, P71, DOI 10.1111/j.1365-2265.2007.02837.x
   Wade M, 2010, EUR J ENDOCRINOL, V162, P109, DOI 10.1530/EJE-09-0746
   Walker BR, 2000, J INTERN MED, V247, P198, DOI 10.1046/j.1365-2796.2000.00609.x
   Ward AMV, 2003, CLIN ENDOCRINOL, V58, P500, DOI 10.1046/j.1365-2265.2003.01750.x
   Wood PJ, 1997, ANN CLIN BIOCHEM, V34, P222, DOI 10.1177/000456329703400302
NR 40
TC 155
Z9 171
U1 1
U2 35
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD JAN
PY 2013
VL 21
IS 1
BP E105
EP E117
DI 10.1002/oby.20083
PG 13
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 187AE
UT WOS:000322086900015
PM 23505190
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Shen, J
   Lai, CQ
   Mattei, J
   Ordovas, JM
   Tucker, KL
AF Shen, Jian
   Lai, Chao-Qiang
   Mattei, Josiemer
   Ordovas, Jose M.
   Tucker, Katherine L.
TI Association of vitamin B-6 status with inflammation, oxidative stress,
   and chronic inflammatory conditions: the Boston Puerto Rican Health
   Study
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID C-REACTIVE PROTEIN; NUTRITION EXAMINATION SURVEY; HISPANIC WHITE ELDERS;
   PYRIDOXAL 5'-PHOSPHATE; MYOCARDIAL-INFARCTION; METABOLIC SYNDROME;
   CARIBBEAN ORIGIN; NATIONAL-HEALTH; DEFICIENT RATS; ACUTE-PHASE
AB Background: Low vitamin B-6 status has been linked to an increased risk of cardiovascular diseases. The cardioprotective effects of vitamin B-6 independent of homocysteine suggest that additional mechanisms may be involved.
   Objective: Our objective was to examine the cross-sectional association of vitamin B-6 status with markers of inflammation and oxidative stress.
   Design: We measured plasma pyridoxal-5'-phosphate (PLP), C-reactive protein (CRP), and ail oxidative DNA damage marker, urinary 8-hydroxydeoxyguanosine (8-OHdG), in Puerto Rican adults who were living in Massachusetts (n = 1205, aged 45-75 y).
   Results: There was a strong dose-response relation of plasma PLP concentration with plasma CRP. Increasing quartiles of PLP were significantly associated with lower CRP concentrations (geometric means: 4.7, 3.6, 3.1, and 2.5 mg/L; P for trend < 0.0001) and with lower urinary 8-OHdG concentrations (geometric means: 124, 124, 117, and 108 ng/mg creatinine; P for trend: 0.025) after multivariate adjustment. These negative associations persisted after plasma homocysteine was controlled for. Plasma PLP concentrations were significantly correlated with plasma fasting glucose (r = -0.1, P = 0.0006), glycated hemoglobin (r = -0.08, P = 0.006), and homeostasis model assessment of beta cell function (r = 0.082, P = 0.005). Metabolic syndrome, obesity, and diabetes were also significantly associated with low plasma PLP concentrations (P = 0.011, 0.0007, and 0.004, respectively).
   Conclusions: Low vitamin B-6 concentrations are associated with inflammation. higher oxidative stress, and metabolic conditions in older Puerto Rican adults. Our data suggest that vitamin B-6 may influence cardiovascular disease risk through mechanisms other than homocysteine and support the notion that nutritional status may influence the health disparities present in this population. Am J Clin Nutr 2010;91:337-42.
C1 [Shen, Jian; Lai, Chao-Qiang; Mattei, Josiemer; Ordovas, Jose M.; Tucker, Katherine L.] Tufts Univ, Human Nutr Res Ctr Aging, Jean Mayer USDA, Boston, MA 02111 USA.
   [Tucker, Katherine L.] Northeastern Univ, Bouve Coll Hlth Sci, Boston, MA 02115 USA.
C3 United States Department of Agriculture (USDA); Tufts University;
   Northeastern University
RP Shen, J (corresponding author), Tufts Univ, Human Nutr Res Ctr Aging, Jean Mayer USDA, 711 Washington St, Boston, MA 02111 USA.
EM jian.shen@tufts.edu
RI Tucker, Katherine/A-4545-2010; Ordovas, Jose/B-8727-2013; Mattei,
   Josiemer/H-1800-2016
OI Tucker, Katherine/0000-0001-7640-662X; Lai,
   Chao-Qiang/0000-0003-1107-8375; Ordovas, Jose/0000-0002-7581-5680;
   Mattei, Josiemer/0000-0001-5424-8245
FU National Institutes of Health, National Institute on Aging
   [01AG023394-02]; National Heart, Lung, and Blood Institute [HL54776]; US
   Department of Agriculture, Agricultural Research Service [53-K06-5-10,
   58-1950-9-001]
FX Supported by the National Institutes of Health, National Institute on
   Aging grant 01AG023394-02 and National Heart, Lung, and Blood Institute
   grant HL54776; and the US Department of Agriculture, Agricultural
   Research Service contracts 53-K06-5-10 and 58-1950-9-001.
CR Aasheim ET, 2008, AM J CLIN NUTR, V87, P362, DOI 10.1093/ajcn/87.2.362
   Amer Diabet Assoc, 2008, DIABETES CARE, V31, pS12, DOI 10.2337/dc08-S012
   Bermudez OI, 2005, J NUTR, V135, P1496, DOI 10.1093/jn/135.6.1496
   Bermudez OI, 2001, OBES RES, V9, P443, DOI 10.1038/oby.2001.58
   Cabrini L, 1998, BIOCHEM MOL BIOL INT, V46, P689
   Chang SJ, 2002, J NUTR, V132, P3603, DOI 10.1093/jn/132.12.3603
   Chiang EPI, 2003, AM J MED, V114, P283, DOI 10.1016/S0002-9343(02)01528-0
   COHEN KL, 1984, J AM POD ASSOC, V74, P394, DOI 10.7547/87507315-74-8-394
   COURSIN DB, 1961, AM J CLIN NUTR, V9, P304, DOI 10.1093/ajcn/9.3.304
   de Maat MPM, 2004, CURR OPIN LIPIDOL, V15, P651, DOI 10.1097/00041433-200412000-00005
   Dierkes J, 2007, AM J CLIN NUTR, V86, P214
   FINKELSTEIN JD, 1970, J NUTR, V100, P467, DOI 10.1093/jn/100.4.467
   Folsom AR, 2003, ATHEROSCLEROSIS, V169, P169, DOI 10.1016/S0021-9150(03)00161-8
   *FOOD NUTR BOARD, 2000, IOMVBIDRIT RIB NIAC
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Friso S, 2004, AM J CLIN NUTR, V79, P992
   Friso S, 2001, CIRCULATION, V103, P2788
   Gao X, 2006, J NUTR, V136, P2574, DOI 10.1093/jn/136.10.2574
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Halliwell B, 1996, ANNU REV NUTR, V16, P33, DOI 10.1146/annurev.nu.16.070196.000341
   Jain SK, 2007, METABOLISM, V56, P168, DOI 10.1016/j.metabol.2006.09.002
   James S, 2000, THROMB RES, V98, P383, DOI 10.1016/S0049-3848(00)00197-3
   Jump DB, 1996, PROG LIPID RES, V35, P227, DOI 10.1016/S0163-7827(96)00007-0
   Kanauchi M, 2002, NEPHRON, V91, P327, DOI 10.1159/000058412
   Kannan K, 2004, FREE RADICAL BIO MED, V36, P423, DOI 10.1016/j.freeradbiomed.2003.09.012
   Komatsu S, 2002, J NUTR SCI VITAMINOL, V48, P65, DOI 10.3177/jnsv.48.65
   Kwan LL, 2002, J NUTR, V132, P2059, DOI 10.1093/jn/132.7.2059
   Lin Hai, 2002, Ethnicity & Disease, V12, P499
   Matsubara K, 2003, INT J MOL MED, V12, P51
   Morris MS, 2008, AM J CLIN NUTR, V87, P1446, DOI 10.1093/ajcn/87.5.1446
   Okada M, 1999, DIABETES OBES METAB, V1, P221, DOI 10.1046/j.1463-1326.1999.00028.x
   Ridker PM, 2001, CIRCULATION, V103, P1813, DOI 10.1161/01.CIR.103.13.1813
   Rimm EB, 1998, JAMA-J AM MED ASSOC, V279, P359, DOI 10.1001/jama.279.5.359
   ROGERS KS, 1994, BIOCHEM MED METAB B, V52, P10, DOI 10.1006/bmmb.1994.1027
   ROUBENOFF R, 1995, ARTHRITIS RHEUM-US, V38, P105, DOI 10.1002/art.1780380116
   Saibeni S, 2003, AM J GASTROENTEROL, V98, P112, DOI 10.1111/j.1572-0241.2003.07160.x
   Sakano N, 2009, J CLIN BIOCHEM NUTR, V44, P185, DOI 10.3164/jcbn.08-252
   Selhub J, 1999, ANNU REV NUTR, V19, P217, DOI 10.1146/annurev.nutr.19.1.217
   SHIN-BUEHRING Y S, 1981, Journal of Inherited Metabolic Disease, V4, P123, DOI 10.1007/BF02263621
   Takatori A, 2004, DIABETES-METAB RES, V20, P211, DOI 10.1002/dmrr.428
   Taysi S, 2005, CLIN NUTR, V24, P385, DOI 10.1016/j.clnu.2004.12.001
   TOYOTA T, 1981, TOHOKU J EXP MED, V134, P331, DOI 10.1620/tjem.134.331
   Tsuge H, 2000, J NUTR, V130, p333S, DOI 10.1093/jn/130.2.333S
   TUCKER K, BMC PUBLIC IN PRESS
   Tucker Katherine L, 2005, J Med Invest, V52 Suppl, P252, DOI 10.2152/jmi.52.252
   Tucker KL, 2000, AM J PUBLIC HEALTH, V90, P1288, DOI 10.2105/AJPH.90.8.1288
   Tucker KL, 1998, AM J EPIDEMIOL, V148, P507, DOI 10.1093/oxfordjournals.aje.a009676
   TULLY DB, 1994, FASEB J, V8, P343, DOI 10.1096/fasebj.8.3.8143940
   Vasilaki AT, 2008, AM J CLIN NUTR, V88, P140, DOI 10.1093/ajcn/88.1.140
   VERMAAK WJH, 1988, KLIN WOCHENSCHR, V66, P428, DOI 10.1007/BF01745511
NR 50
TC 110
Z9 121
U1 0
U2 9
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD FEB
PY 2010
VL 91
IS 2
BP 337
EP 342
DI 10.3945/ajcn.2009.28571
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 548GG
UT WOS:000273947500007
PM 19955400
OA Green Published
DA 2025-06-11
ER

PT J
AU Cadeddu, C
   Nocco, S
   Deidda, M
   Pau, F
   Colonna, P
   Mercuro, G
AF Cadeddu, Christian
   Nocco, Silvio
   Deidda, Martino
   Pau, Fabio
   Colonna, Paolo
   Mercuro, Giuseppe
TI Altered Transmural Contractility in Postmenopausal Women Affected by
   Cardiac Syndrome X
SO JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
LA English
DT Article
DE Cardiac syndrome X; Exercise echocardiography; Speckle-tracking
   echocardiography
ID NORMAL CORONARY ARTERIOGRAMS; LEFT-VENTRICULAR FUNCTION;
   ANGINA-PECTORIS; CHEST-PAIN; ECHOCARDIOGRAPHY; EXERCISE; PERFUSION;
   RESERVE; STRESS; OBSTRUCTION
AB Background: Cardiac syndrome X (CSX) is characterized by typical angina and abnormal exercise test results, with normal coronary arteries. Cardiovascular magnetic resonance imaging has shown subendocardial hypoperfusion in patients with CSX after adenosine. The aim of this study was to investigate the contribution of separate myocardial layers to global function under stress in women with CSX.
   Methods: Twenty-two postmenopausal women with CSX were studied and compared with 20 healthy women matched for age and body mass index. All subjects underwent clinical evaluations and exercise echocardiography. Left ventricular systolic and diastolic parameters were evaluated at rest and at peak exercise. Layer-specific global longitudinal strain (GLS) and strain rate (SR) were assessed from the endocardium, midmyocardium, and epicardium using two-dimensional speckle-tracking echocardiography.
   Results: All subjects showed normal contractile function at rest and at peak exercise. Significant increases in GLS and SR in all myocardial layers were observed at peak exercise in the control group, whereas patients with CSX showed significantly lower increases in endocardial GLS and SR compared with the control group (endocardial Delta SR, 0.17 +/- 0.19 vs 0.33 +/- 0.13 [P < .01]; endocardial Delta GLS, 1.33 +/- 2.93 vs 6.64 +/- 2.62 [P < .001]). Moreover, significantly impaired diastolic function (Delta E', 1.1 +/- 3.3 vs 4.0 +/- 2.03) was observed in patients with CSX.
   Conclusions: The results of this study show subendocardial impairment of contractile function during exercise in patients with CSX, confirming the existence of reduced myocardial perfusion reserve in patients with CSX and suggesting layer-targeted exercise echocardiography as a sensitive diagnostic tool in the assessment of suspected CSX.
C1 [Cadeddu, Christian; Nocco, Silvio; Deidda, Martino; Pau, Fabio; Mercuro, Giuseppe] Univ Cagliari, Dept Med Sci, Monserrato, Italy.
   [Colonna, Paolo] Policlin Hosp, Dept Cardiol, Bari, Italy.
C3 University of Cagliari
RP Cadeddu, C (corresponding author), Univ Hosp Cagliari, Dept Med Sci, Str Statale 554,Km 4-500, I-09042 Cagliari, Italy.
EM cadedduc@unica.it
RI Colonna, Paolo/N-8144-2016; Cadeddu, Christian/AAI-9219-2020; Deidda,
   Martino/V-4453-2019; Deidda, Martino/L-3166-2015
OI Cadeddu, Christian/0000-0002-2823-1797; Deidda,
   Martino/0000-0002-3725-7614; mercuro, giuseppe/0000-0003-0097-2152;
   Colonna, Paolo/0000-0001-5864-2012
CR Cabrera-Bueno F, 2007, J AM SOC ECHOCARDIOG, V20, P415, DOI 10.1016/j.echo.2006.09.009
   CAMICI PG, 1992, CIRCULATION, V86, P179, DOI 10.1161/01.CIR.86.1.179
   CANNON RO, 1985, CIRCULATION, V71, P218, DOI 10.1161/01.CIR.71.2.218
   Chen X, 2011, ECHOCARDIOGR-J CARD, V28, P181, DOI 10.1111/j.1540-8175.2010.01287.x
   D'hooge J, 2000, Eur J Echocardiogr, V1, P154, DOI 10.1053/euje.2000.0031
   GALASSI AR, 1993, AM J CARDIOL, V72, P134, DOI 10.1016/0002-9149(93)90148-6
   Geyer H, 2010, J AM SOC ECHOCARDIOG, V23, P351, DOI 10.1016/j.echo.2010.02.015
   Hashimoto I, 2003, J AM COLL CARDIOL, V42, P1574, DOI 10.1016/j.jacc.2003.05.002
   KASKI JC, 1995, J AM COLL CARDIOL, V25, P807, DOI 10.1016/0735-1097(94)00507-M
   KEMP HG, 1986, J AM COLL CARDIOL, V7, P479, DOI 10.1016/S0735-1097(86)80456-9
   KEMP HG, 1973, AM J CARDIOL, V32, P375, DOI 10.1016/S0002-9149(73)80150-X
   LEGRAND V, 1985, J AM COLL CARDIOL, V6, P1245, DOI 10.1016/S0735-1097(85)80209-6
   Meeder JG, 1995, EUR HEART J, V16, P1571, DOI 10.1093/oxfordjournals.eurheartj.a060780
   Montalescot G, 2013, EUR HEART J, V34, P2949, DOI 10.1093/eurheartj/eht296
   Mor-Avi V, 2011, J AM SOC ECHOCARDIOG, V24, P277, DOI 10.1016/j.echo.2011.01.015
   MUKERJI V, 1993, TEX HEART I J, V20, P170
   NIHOYANNOPOULOS P, 1991, J AM COLL CARDIOL, V18, P1463, DOI 10.1016/0735-1097(91)90676-Z
   Panting JR, 2002, NEW ENGL J MED, V346, P1948, DOI 10.1056/NEJMoa012369
   PELLIKKA PA, 1992, CIRCULATION, V86, P1429, DOI 10.1161/01.CIR.86.5.1429
   PICANO E, 1987, AM J CARDIOL, V60, P508, DOI 10.1016/0002-9149(87)90295-5
   Rinkevich D, 2013, J AM SOC ECHOCARDIOG, V26, P290, DOI 10.1016/j.echo.2012.12.008
   Rosen D, 1994, CIRCULATION, V90, P50
   Sarvari SI, 2013, JACC-CARDIOVASC IMAG, V6, P535, DOI 10.1016/j.jcmg.2013.01.009
   Schindler TH, 2003, HEART, V89, P517, DOI 10.1136/heart.89.5.517
   TWEDDEL AC, 1992, BRIT HEART J, V68, P48
   Vermeltfoort IAC, 2010, CLIN RES CARDIOL, V99, P475, DOI 10.1007/s00392-010-0159-1
   Zouridakis EG, 2000, HEART, V83, P141, DOI 10.1136/heart.83.2.141
NR 27
TC 17
Z9 18
U1 0
U2 4
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0894-7317
J9 J AM SOC ECHOCARDIOG
JI J. Am. Soc. Echocardiogr.
PD FEB
PY 2014
VL 27
IS 2
BP 208
EP 214
DI 10.1016/j.echo.2013.09.014
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 296WZ
UT WOS:000330217400011
PM 24161482
DA 2025-06-11
ER

PT J
AU Palachai, N
   Wattanathorn, J
   Muchimapura, S
   Thukham-mee, W
AF Palachai, Nut
   Wattanathorn, Jintanaporn
   Muchimapura, Supaporn
   Thukham-mee, Wipawee
TI Phytosome Loading the Combined Extract of Mulberry Fruit and Ginger
   Protects against Cerebral Ischemia in Metabolic Syndrome Rats
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID PPAR-GAMMA; OXIDATIVE STRESS; STROKE; HEALTH; ASSOCIATION; COMPONENTS;
   AGONISTS; RISK
AB The prevalence of ischemic stroke in metabolic syndrome (MetS) is continually increasing and produces a great impact on both qualities of life and annual healthcare budget. Due to the efficiency limitation of the current therapeutic strategy, the poor availability of polyphenol substances induced by the first pass effect and the beneficial effects of mulberry fruit and ginger on brain and MetS-related diseases together with the synergistic concept, the neuroprotective effect against ischemic stroke in MetS condition of phytosome containing the combined extract of mulberry fruit and ginger (PMG) has been considered. To explore the neuroprotective effect and possible underlying mechanism of PMG on brain damage in cerebral ischemic rat with MetS, male Wistar rats were induced MetS by high-carbohydrate high-fat diet (HCHF) for 16 weeks and subjected to the cerebral ischemia/reperfusion injury (CIRI) at the right middle cerebral artery (Rt. MCAO). PMG at doses of 50, 100, and 200 mg/kg were orally fed with for 21 days, and they were assessed brain damage, neurological deficit score, and the changes of oxidative stress markers, inflammatory markers, PPAR gamma expression, and epigenetic modification via DNMT-1 were performed. All doses of PMG significantly improved brain infarction, brain edema, and neurological deficit score. In addition, the reduction in DNMT-1, MDA level, NF-kappa B, TNF alpha, and C-reactive protein together with the increase in SOD, CAT, and GPH-Px activities, and PPAR gamma expression in the lesion brain were also observed. The current data clearly revealed the neuroprotective effect against cerebral ischemia with MetS condition. The possible underlying mechanism might occur partly via the suppression of DNMT-1 giving rise to the improvement of signal transduction via PPAR gamma resulting in the decreasing of inflammation and oxidative stress. In conclusion, PMG is the potential neuroprotectant candidate against ischemic stroke in the MetS condition. However, the clinical trial is still essential.
C1 [Palachai, Nut] Khon Kaen Univ, Dept Physiol, Khon Kaen 40002, Thailand.
   [Palachai, Nut] Khon Kaen Univ, Grad Sch, Neurosci Program, Fac Med, Khon Kaen 40002, Thailand.
   [Palachai, Nut; Wattanathorn, Jintanaporn; Muchimapura, Supaporn; Thukham-mee, Wipawee] Khon Kaen Univ, Res Inst Human High Performance & Hlth Promot, Integrat Complementary Alternat Med Res & Dev Ctr, Khon Kaen 40002, Thailand.
   [Wattanathorn, Jintanaporn; Muchimapura, Supaporn; Thukham-mee, Wipawee] Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
C3 Khon Kaen University; Khon Kaen University; Khon Kaen University; Khon
   Kaen University
RP Wattanathorn, J (corresponding author), Khon Kaen Univ, Res Inst Human High Performance & Hlth Promot, Integrat Complementary Alternat Med Res & Dev Ctr, Khon Kaen 40002, Thailand.; Wattanathorn, J (corresponding author), Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
EM jinwat05@gmail.com
RI Palachai, Nut/HKM-6781-2023
OI Palachai, Nut/0000-0002-9672-9941; Wattanathorn,
   Jintanaporn/0000-0002-7383-2348; Muchimapura,
   Supaporn/0000-0001-7756-1955; Thukhammee, Wipawee/0000-0001-6923-396X
FU Royal Golden Jubilee (RGJ) Ph.D. is a part of Thailand Research Fund
   (TRF) [PHD/0181/2558]; Integrative Complementary Alternative Medicine
   Research and Development Center in Research Institute for Human High
   Performance and Health Promotion, Khon Kaen University, Khon Kaen,
   Thailand
FX This study was supported by The Royal Golden Jubilee (RGJ) Ph.D. which
   is a part of Thailand Research Fund (TRF). (Research No. PHD/0181/2558)
   and the Integrative Complementary Alternative Medicine Research and
   Development Center in Research Institute for Human High Performance and
   Health Promotion, Khon Kaen University, Khon Kaen, Thailand.
CR Aho K., 2005, B WORLD HEALTH ORGAN, V58, P113
   [Anonymous], ASIAN J PHARM CLIN R
   Chen H, 2011, ANTIOXID REDOX SIGN, V14, P1505, DOI 10.1089/ars.2010.3576
   Choi KH, 2016, J MED FOOD, V19, P737, DOI 10.1089/jmf.2016.3665
   Collino M, 2006, EUR J PHARMACOL, V530, P70, DOI 10.1016/j.ejphar.2005.11.049
   Culman J, 2007, TRENDS PHARMACOL SCI, V28, P244, DOI 10.1016/j.tips.2007.03.004
   de Lores Arnaiz Georgina Rodriguez, 2014, Int J Biomed Sci, V10, P85
   Dostovic Zikrija, 2016, Med Arch, V70, P339
   Giampietro L, 2019, NEUROCHEM INT, V126, P239, DOI 10.1016/j.neuint.2019.03.021
   GOTH L, 1991, CLIN CHIM ACTA, V196, P143, DOI 10.1016/0009-8981(91)90067-M
   Hankey GJ, 1999, ARCH NEUROL-CHICAGO, V56, P748, DOI 10.1001/archneur.56.6.748
   Jia YY, 2013, BBA-MOL CELL BIOL L, V1831, P698, DOI 10.1016/j.bbalip.2012.11.012
   Jittiwat J, 2012, J ACUPUNCT MERIDIAN, V5, P295, DOI 10.1016/j.jams.2012.09.003
   Kaewkaen P, 2012, EVID-BASED COMPL ALT, V2012, DOI 10.1155/2012/263520
   Kim M, 2017, J CANCER PREV, V22, P174, DOI 10.15430/JCP.2017.22.3.174
   Kirisattayakul W, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/5187102
   Kotani K, 2015, CARDIOVASC DIABETOL, V14, DOI 10.1186/s12933-015-0272-6
   Lawrence T, 2011, NAT REV IMMUNOL, V11, P750, DOI 10.1038/nri3088
   Milionis HJ, 2005, STROKE, V36, P1372, DOI 10.1161/01.STR.0000169935.35394.38
   Nagel S, 2007, BRAIN RES, V1132, P210, DOI 10.1016/j.brainres.2006.11.023
   Nichols GA, 2011, METAB SYNDR RELAT D, V9, P127, DOI 10.1089/met.2010.0105
   Ninomiya JK, 2004, CIRCULATION, V109, P42, DOI 10.1161/01.CIR.0000108926.04022.0C
   Ohnon W, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/9089035
   Ovbiagele B, 2006, NEUROLOGY, V66, P1344, DOI 10.1212/01.wnl.0000210530.46058.5c
   Palachai N, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/5972575
   Raman ST, 2016, PHARMACOGN MAG, V12, P128, DOI 10.4103/0973-1296.177910
   ROTRUCK JT, 1973, SCIENCE, V179, P588, DOI 10.1126/science.179.4073.588
   Suk SH, 2003, STROKE, V34, P1586, DOI 10.1161/01.STR.0000075294.98582.2F
   SUN Y, 1988, CLIN CHEM, V34, P497
   Vital S. A., 2016, J VISUALIZED EXPT, V116, P1
   Wang LM, 2014, BIOCHEM PHARMACOL, V92, P73, DOI 10.1016/j.bcp.2014.07.018
   Wang WB, 2015, J NEUROL SCI, V348, P121, DOI 10.1016/j.jns.2014.11.018
   Wattanathorn J, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/9658267
   Wattanathorn J, 2011, EVID-BASED COMPL ALT, V2011, P1, DOI 10.1155/2011/429505
   Yang QW, 2019, FRONT NEUROSCI-SWITZ, V13, DOI 10.3389/fnins.2019.01036
   Yu J, 2016, SCI REP-UK, V6, DOI 10.1038/srep30053
   Yuan QX, 2017, J AGR FOOD CHEM, V65, P10383, DOI 10.1021/acs.jafc.7b03614
NR 37
TC 19
Z9 22
U1 0
U2 11
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD JUL 25
PY 2020
VL 2020
AR 5305437
DI 10.1155/2020/5305437
PG 15
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA MZ4ZH
UT WOS:000559133200001
PM 32774678
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Mustieles, V
   Arrebola, JP
AF Mustieles, Vicente
   Arrebola, Juan P.
TI How polluted is your fat? What the study of adipose tissue can
   contribute to environmental epidemiology
SO JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
LA English
DT Article
ID PERSISTENT ORGANIC POLLUTANTS; OXIDATIVE STRESS; ADULT COHORT; ENDOCRINE
   DISRUPTORS; METABOLIC SYNDROME; EXPOSURE; ASSOCIATIONS; HEALTH; OBESITY;
   CANCER
AB The study of the potential contribution of low-dose exposure to environmental chemicals on the development of chronic conditions in human populations is often hampered by methodological issues, including exposure misclassification and the inability to assess biological effects in target organs. White adipose tissue (WAT) presents the unique feature of being both an advantageous matrix for assessing long-term exposure to mixtures of persistent organic pollutants and an interesting tissue to investigate early preclinical effects. Moreover, other lipophilic non-persistent chemicals and heavy metals have been recently quantified in fat, suggesting that human WAT contains chemical mixtures more complex than initially thought. However, WAT has been scarcely used in environmental epidemiology due to collection difficulties. In this essay we discuss the potential of using human WAT as a source of both exposure and effect biomarkers, with the aim of advancing the epidemiological research of obesity-related diseases, including metabolic syndrome and cancer. Overall, we discuss the implications of investigating WAT in a multidisciplinary framework combining toxicological and epidemiological knowledge in order to improve the inference of causal relationships in observational settings. We finalise by suggesting feasible designs and scenarios in which WAT samples may be reasonably collected.
C1 [Mustieles, Vicente] Univ Granada, Ctr Biomed Res CIBM, Granada, Spain.
   [Mustieles, Vicente; Arrebola, Juan P.] CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain.
   [Mustieles, Vicente; Arrebola, Juan P.] Inst Invest Biosanitaria Ibs GRANADA, Granada, Spain.
   [Arrebola, Juan P.] Univ Granada, Dept Prevent Med & Publ Hlth, Granada 18071, Spain.
C3 University of Granada; CIBER - Centro de Investigacion Biomedica en Red;
   CIBERESP; Instituto de Investigacion Biosanitaria IBS Granada;
   University of Granada
RP Arrebola, JP (corresponding author), Univ Granada, Dept Prevent Med & Publ Hlth, Granada 18071, Spain.
EM jparrebola@ugr.es
RI Mustieles, Vicente/KAM-1750-2024; Arrebola, Juan/A-5205-2017
OI Mustieles, Vicente/0000-0002-2010-5438; Arrebola, Juan
   P./0000-0002-8643-2423
FU Ramon y Cajal program (Ministerio de Economia, Industria y
   Competitividad, Spain) [RYC-2016-20155]; Human Biomonitoring for Europe
   Project (European Union Commission) [H2020-EJP-HBM4EU]; Instituto de
   Salud Carlos III [FIS-PI16/01858]
FX JPA is under contract within Ramon y Cajal program (RYC-2016-20155,
   Ministerio de Economia, Industria y Competitividad, Spain). VM is under
   contract within the Human Biomonitoring for Europe Project (European
   Union Commission H2020-EJP-HBM4EU). The authors acknowledge the funding
   received from Instituto de Salud Carlos III (FIS-PI16/01858).
CR Abdollahi M, 2004, MED SCI MONITOR, V10, pRA141
   ArchibequeEngle SL, 1997, J TOXICOL ENV HEALTH, V52, P285, DOI 10.1080/009841097159584
   Arrebola JP, 2016, SCI TOTAL ENVIRON, V566, P41, DOI 10.1016/j.scitotenv.2016.04.188
   Arrebola JP, 2012, REPROD TOXICOL, V33, P45, DOI 10.1016/j.reprotox.2011.10.015
   Arrebola JP, 2014, SCI TOTAL ENVIRON, V500, P243, DOI 10.1016/j.scitotenv.2014.08.043
   Arrebola JP, 2014, ENVIRON POLLUT, V195, P9, DOI 10.1016/j.envpol.2014.08.003
   Arrebola JP, 2013, ENVIRON RES, V122, P31, DOI 10.1016/j.envres.2012.12.001
   Artacho-Cordón F, 2019, ENVIRON INT, V133, DOI 10.1016/j.envint.2019.105118
   Artacho-Cordón F, 2018, ENVIRON INT, V119, P203, DOI 10.1016/j.envint.2018.05.052
   Artacho-Cordón F, 2016, ENVIRON SCI TECHNOL, V50, P13529, DOI 10.1021/acs.est.6b03783
   Bansal A, 2018, ENDOCRINOLOGY, V159, P32, DOI 10.1210/en.2017-00882
   Bjerregaard-Olesen C, 2019, ENVIRON HEALTH PERSP, V127, DOI [10.1289/EHP1884, 10.1289/ehp1884]
   Braun JM, 2016, ENVIRON HEALTH PERSP, V124, pA6, DOI 10.1289/ehp.1510569
   Cano-Sancho G, 2018, CHEMOSPHERE, V200, P388, DOI 10.1016/j.chemosphere.2018.02.120
   Castellano-Castillo D, 2019, J CLIN MED, V8, DOI 10.3390/jcm8010087
   Conder JM, 2008, ENVIRON SCI TECHNOL, V42, P995, DOI 10.1021/es070895g
   Cusi K, 2010, CURR DIABETES REP, V10, P306, DOI 10.1007/s11892-010-0122-6
   Darbre PD, 2017, CURR OBES REP, V6, P18, DOI 10.1007/s13679-017-0240-4
   Decaprio AP, 1997, ENVIRON SCI TECHNOL, V31, P1837, DOI 10.1021/es960920a
   Echeverría R, 2019, SCI TOTAL ENVIRON, V670, P1028, DOI 10.1016/j.scitotenv.2019.03.114
   Fan JJ, 2019, ENVIRON POLLUT, V247, P999, DOI 10.1016/j.envpol.2019.01.113
   Ferguson KK, 2017, ENVIRON HEALTH PERSP, V125, P488, DOI 10.1289/EHP282
   Fernández-Sánchez A, 2011, INT J MOL SCI, V12, P3117, DOI 10.3390/ijms12053117
   Gaskins AJ, 2009, METHODS MOL BIOL, V580, P371, DOI 10.1007/978-1-60761-325-1_20
   Heindel JJ, 2017, REPROD TOXICOL, V68, P3, DOI 10.1016/j.reprotox.2016.10.001
   Ibrahim MM, 2010, OBES REV, V11, P11, DOI 10.1111/j.1467-789X.2009.00623.x
   Ibrahim MM, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0025170
   Jain P, 2018, J EPIDEMIOL COMMUN H, V72, P564, DOI 10.1136/jech-2017-210061
   Jin YX, 2017, ENVIRON POLLUT, V222, P1, DOI 10.1016/j.envpol.2016.11.045
   Kennedy N, 2017, OBES RES CLIN PRACT, V11, P655, DOI 10.1016/j.orcp.2017.10.003
   Kim KS, 2014, CHEMOSPHERE, V94, P151, DOI 10.1016/j.chemosphere.2013.09.066
   KOHLMEIER L, 1995, ENVIRON HEALTH PERSP, V103, P99, DOI 10.2307/3432569
   La Merrill M, 2013, ENVIRON HEALTH PERSP, V121, P162, DOI 10.1289/ehp.1205485
   Lange T, 2017, EPIDEMIOL HEALTH, V39, DOI 10.4178/epih.e2017035
   Lee DH, 2019, J EPIDEMIOL COMMUN H, V73, P193, DOI 10.1136/jech-2018-210920
   Lee DH, 2015, J EPIDEMIOL COMMUN H, V69, P294, DOI 10.1136/jech-2014-203861
   Lee YM, 2017, OBES REV, V18, P129, DOI 10.1111/obr.12481
   Lee YM, 2011, J EPIDEMIOL COMMUN H, V65, pA387, DOI 10.1136/jech.2011.142976n.24
   Lee YM, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00712
   Lengyel E, 2018, TRENDS CANCER, V4, P374, DOI 10.1016/j.trecan.2018.03.004
   López-Jaramillo P, 2014, HORM MOL BIOL CLIN I, V18, P37, DOI 10.1515/hmbci-2013-0053
   Malarvannan G, 2013, ENVIRON INT, V55, P33, DOI 10.1016/j.envint.2013.02.012
   Manna P, 2015, METAB SYNDR RELAT D, V13, P423, DOI 10.1089/met.2015.0095
   Maury E, 2010, MOL CELL ENDOCRINOL, V314, P1, DOI 10.1016/j.mce.2009.07.031
   Messerlian C, 2017, NAT REV ENDOCRINOL, V13, P740, DOI 10.1038/nrendo.2017.81
   Mori C, 2017, J EPIDEMIOL COMMUN H, V71, P660, DOI 10.1136/jech-2016-208088
   Mustieles V, 2018, HUM REPROD, V33, P1528, DOI 10.1093/humrep/dey234
   Mustieles V, 2017, ENVIRON INT, V104, P48, DOI 10.1016/j.envint.2017.04.002
   National Research Council, 1991, REV NAT HUM AD TISS
   O'Brien Katie M, 2017, Curr Environ Health Rep, V4, P44, DOI 10.1007/s40572-017-0122-7
   Pearl J, 2014, PSYCHOL METHODS, V19, P459, DOI 10.1037/a0036434
   Pereira-Fernandes A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0084816
   Perrier F, 2016, EPIDEMIOLOGY, V27, P378, DOI 10.1097/EDE.0000000000000460
   Pestana D, 2014, ENVIRON RES, V133, P170, DOI 10.1016/j.envres.2014.05.026
   Porta M, 2014, A dictionary of epidemiology
   Porta M, 2008, ENVIRON INT, V34, P546, DOI 10.1016/j.envint.2007.10.004
   Sheikh MA, 2017, J EPIDEMIOL COMMUNIT, V3
   Stein RA, 2012, J EPIDEMIOL COMMUN H, V66, P8, DOI 10.1136/jech.2010.130690
   Varadhan R, 2014, J GERONTOL A-BIOL, V69, P165, DOI 10.1093/gerona/glt023
   Wang AL, 2018, ENVIRON HEALTH PERSP, V126, DOI [10.1289/EHP2920, 10.1289/ehp2920]
   Wang HT, 2018, TOXICOL SCI, V162, P372, DOI 10.1093/toxsci/kfx259
   Wang L, 2015, ENVIRON INT, V78, P45, DOI 10.1016/j.envint.2015.02.015
   Wang L, 2015, ENVIRON SCI TECHNOL, V49, P3150, DOI 10.1021/acs.est.5b00096
   Wang Q, 2017, SCI TOTAL ENVIRON, V598, P814, DOI 10.1016/j.scitotenv.2017.04.167
NR 64
TC 34
Z9 37
U1 0
U2 8
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0143-005X
EI 1470-2738
J9 J EPIDEMIOL COMMUN H
JI J. Epidemiol. Community Health
PD MAY
PY 2020
VL 74
IS 5
BP 401
EP 407
DI 10.1136/jech-2019-213181
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA NM6LJ
UT WOS:000568206800001
PM 32019765
DA 2025-06-11
ER

PT J
AU Bahadoran, Z
   Mirmiran, P
   Jeddi, S
   Carlström, M
   Azizi, F
   Ghasemi, A
AF Bahadoran, Zahra
   Mirmiran, Parvin
   Jeddi, Sajad
   Carlstrom, Mattias
   Azizi, Fereidoun
   Ghasemi, Asghar
TI Circulating markers of nitric oxide homeostasis and cardiometabolic
   diseases: insights from population-based studies
SO FREE RADICAL RESEARCH
LA English
DT Review
DE Cardiovascular disease; chronic kidney disease; hypertension; metabolic
   syndrome; nitrate; nitric oxide; nitrite; type 2 diabetes
ID CHRONIC KIDNEY-DISEASE; INSULIN-RESISTANCE; DIETARY NITRATE;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; BLOOD-PRESSURE; METABOLITES
   NITRITE; GENDER-DIFFERENCES; CIGARETTE-SMOKING; ADIPOSE-TISSUE
AB Emerging data suggest that impaired nitric oxide (NO) homeostasis has a key role in development of cardiometabolic disorders. The association between circulating levels of NO metabolites, i.e. nitrate and nitrite (NOx), and risk of chronic diseases has not yet been fully clarified. This work aims to address epidemiologic aspects of NO metabolism and discusses different physiologic and pathophysiologic conditions influencing circulating NOx. Further, cross-sectional associations of serum NOx with metabolic disorders are described and along the way, potential short-term and long-term power of serum NOx for predicting cardiometabolic outcomes are reviewed. Results from population-based studies show that circulating NOx is affected by aging, smoking habits, pregnancy, menopause status, thyroid hormones, and various pathologic conditions including type 2 diabetes, insulin resistance, hypertension, and renal dysfunction. Lifestyle factors, especially dietary habits, but also smoking habits and the degree of physical activity influence NO homeostasis and the circulating levels of NOx. Elevated serum NOx, due to increased iNOS activity, is associated with increased incidence of metabolic syndrome, different obesity phenotypes, and cardiovascular events.
C1 [Bahadoran, Zahra] Shahid Beheshti Univ Med Sci, Nutr & Endocrine Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
   [Mirmiran, Parvin] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Dept Clin Nutr & Diet Therapy, Tehran, Iran.
   [Jeddi, Sajad; Ghasemi, Asghar] Shahid Beheshti Univ Med Sci, Endocrine Physiol Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
   [Carlstrom, Mattias] Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.
   [Azizi, Fereidoun] Shahid Beheshti Univ Med Sci, Endocrine Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Shahid Beheshti University Medical Sciences;
   Karolinska Institutet; Shahid Beheshti University Medical Sciences
RP Ghasemi, A (corresponding author), 24 Sahid Erabi St,Yemen St,Chamran Exp, Tehran, Iran.
EM ghasemi@endocrine.ac.ir
RI Bahadoran, Zahra/V-2003-2019; Jeddi, Sajad/U-8493-2019; Mirmiran,
   Parvin/V-1433-2019; Azizi, Fereidoun/ABD-4136-2021; Carlstrom,
   Mattias/E-7350-2015; Ghasemi, Asghar/O-4145-2017
OI Azizi, Fereidoun/0000-0002-6470-2517; Carlstrom,
   Mattias/0000-0001-9923-8729; Mirmiran, Parvin/0000-0003-2391-4924;
   Ghasemi, Asghar/0000-0001-6867-2151; Jeddi, Sajad/0000-0002-3911-6620
FU Shahid Beheshti University of Medical Sciences [5-1396/D/101865]
FX This study was supported by Shahid Beheshti University of Medical
   Sciences (Grant no. 5-1396/D/101865).
CR Adela R, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0125270
   Adkisson EJ, 2008, THESIS
   Akarasereenont Pravit, 2001, Journal of the Medical Association of Thailand, V84, pS730
   Allen JD, 2012, NITRIC OXIDE-BIOL CH, V26, P217, DOI 10.1016/j.niox.2012.03.003
   Anazawa T, 2004, ARTERIOSCL THROM VAS, V24, P1652, DOI 10.1161/01.ATV.0000139925.84444.ad
   Asl SZ, 2008, CLIN BIOCHEM, V41, P1342, DOI 10.1016/j.clinbiochem.2008.08.076
   Assmann TS, 2016, NITRIC OXIDE-BIOL CH, V61, P1, DOI 10.1016/j.niox.2016.09.009
   Atta MN, 2011, ALEX J MED, V47, P267, DOI 10.1016/j.ajme.2011.09.004
   Avogaro A, 2005, CLIN CHIM ACTA, V360, P9, DOI 10.1016/j.cccn.2005.04.020
   Bagheripuor F, 2016, ENDOCR RES, V41, P193, DOI 10.3109/07435800.2015.1126844
   Bahadoran Z, 2019, IRAN J PUBLIC HEALTH, V48, P162
   Bahadoran Z, 2016, SCAND J CLIN LAB INV, V76, P304, DOI 10.3109/00365513.2016.1149880
   Bahadoran Z, 2015, NITRIC OXIDE-BIOL CH, V50, P52, DOI 10.1016/j.niox.2015.08.002
   Bahadoran Z, 2015, NUTR METAB, V12, DOI 10.1186/s12986-015-0013-6
   Bahadoran ZM, 2015, 5 WORLD C CONTR CONS
   Balci H, 2005, MATURITAS, V50, P289, DOI 10.1016/j.maturitas.2004.07.002
   Baylis C, 1998, CURR OPIN NEPHROL HY, V7, P59, DOI 10.1097/00041552-199801000-00010
   Baylis C, 2008, AM J PHYSIOL-RENAL, V294, pF1, DOI 10.1152/ajprenal.00424.2007
   Beberashvili I, 2013, INT UROL NEPHROL, V45, P1703, DOI 10.1007/s11255-013-0436-9
   Bednarek-Tupikowska G, 2008, J ENDOCRINOL INVEST, V31, P877, DOI 10.1007/BF03346435
   Belmont HM, 1997, ARTHRITIS RHEUM, V40, P1810, DOI 10.1002/art.1780401013
   BENJAMIN N, 1994, NATURE, V368, P502, DOI 10.1038/368502a0
   Blekkenhorst LC, 2018, AM J CLIN NUTR, V107, P504, DOI 10.1093/ajcn/nqx046
   Blum M, 1998, NEPHRON, V79, P265, DOI 10.1159/000045047
   Bryan NS, 2008, FREE RADICAL BIO MED, V45, P468, DOI 10.1016/j.freeradbiomed.2008.04.040
   Bryan NS, 2012, PHARMACOL RES, V66, P448, DOI 10.1016/j.phrs.2012.09.009
   BUGA GM, 1993, CIRC RES, V73, P808, DOI 10.1161/01.RES.73.5.808
   BUTTERY LDK, 1994, PLACENTA, V15, P257, DOI 10.1016/0143-4004(94)90017-5
   Caimi G, 2014, CLIN HEMORHEOL MICRO, V56, P359, DOI 10.3233/CH-131758
   Caimi G, 2012, DIABETES METAB SYND, V6, P132, DOI 10.1016/j.dsx.2012.09.012
   Carlström M, 2015, ANTIOXID REDOX SIGN, V23, P295, DOI 10.1089/ars.2013.5481
   Carlström M, 2015, PHYSIOL REV, V95, P405, DOI 10.1152/physrev.00042.2012
   Carrillo-Sepúlveda MA, 2010, CARDIOVASC RES, V85, P560, DOI 10.1093/cvr/cvp304
   Castiglione N, 2012, ANTIOXID REDOX SIGN, V17, P684, DOI 10.1089/ars.2011.4196
   Castillo L, 1996, P NATL ACAD SCI USA, V93, P11460, DOI 10.1073/pnas.93.21.11460
   Cau SBA, 2012, FRONT PHYSIOL, V3, DOI 10.3389/fphys.2012.00218
   Chaturvedi P, 2018, INDIAN J CLIN BIOCHE, V33, P322, DOI 10.1007/s12291-017-0677-y
   Chien SJ, 2014, TRANSL RES, V163, P43, DOI 10.1016/j.trsl.2013.09.008
   Chu SY, 2004, AM J PHYSIOL-RENAL, V287, pF384, DOI 10.1152/ajprenal.00006.2004
   Codoñer-Franch P, 2014, CLIN BIOCHEM, V47, P44, DOI 10.1016/j.clinbiochem.2013.10.021
   Correia-Costa L, 2016, BRIT J NUTR, V116, P805, DOI 10.1017/S0007114516002804
   D'Agostino RB, 2013, GLOB HEART, V8, P11, DOI 10.1016/j.gheart.2013.01.001
   DOMINICZAK AF, 1995, HYPERTENSION, V25, P1202, DOI 10.1161/01.HYP.25.6.1202
   Elizalde M, 2000, J LIPID RES, V41, P1244
   Emdin CA, 2018, CIRCULATION, V137, P222, DOI 10.1161/CIRCULATIONAHA.117.028021
   Engeli S, 2004, J LIPID RES, V45, P1640, DOI 10.1194/jlr.M300322-JLR200
   Esmailnasab N, 2012, IRAN J PUBLIC HEALTH, V41, P77
   Ferlito S, 1997, Minerva Cardioangiol, V45, P553
   Fujita K, 2011, MED SCI MONITOR, V17, pCR123, DOI 10.12659/MSM.881445
   Ge Y, 2012, J INTERN MED, V272, P430, DOI 10.1111/j.1365-2796.2012.02589.x
   Ghasemi A, 2011, INT ANGIOL, V30, P380
   Ghasemi A, 2008, LIFE SCI, V83, P326, DOI 10.1016/j.lfs.2008.06.010
   Ghasemi A, 2012, CLIN LAB, V58, P615, DOI 10.7754/Clin.Lab.2011.110908
   Ghasemi A, 2015, ACTA DIABETOL, V52, P905, DOI 10.1007/s00592-015-0730-3
   Ghasemi A, 2013, ARCH IRAN MED, V16, P521, DOI 013169/AIM.008
   Ghasemi A, 2012, SCAND J CLIN LAB INV, V72, P523, DOI 10.3109/00365513.2012.701322
   Ghasemi Asghar, 2011, Iranian Biomedical Journal, V15, P59
   Ghasemi A, 2011, ANN HUM BIOL, V38, P577, DOI 10.3109/03014460.2011.575384
   Ghasemi A, 2010, NITRIC OXIDE-BIOL CH, V23, P264, DOI 10.1016/j.niox.2010.07.007
   Ghasemi A, 2010, SCAND J CLIN LAB INV, V70, P116, DOI 10.3109/00365511003611282
   Ghasemi A, 2010, EUR J EPIDEMIOL, V25, P45, DOI 10.1007/s10654-009-9382-3
   Ghasemi A, 2010, CLIN BIOCHEM, V43, P89, DOI 10.1016/j.clinbiochem.2009.09.011
   Gheibi S, 2018, NITRIC OXIDE-BIOL CH, V75, P27, DOI 10.1016/j.niox.2018.02.002
   Ghosh Amrita, 2011, Int J Appl Basic Med Res, V1, P31, DOI 10.4103/2229-516X.81977
   Giovannoni G, 1997, ANN CLIN BIOCHEM, V34, P193, DOI 10.1177/000456329703400212
   Golzarand M, 2016, J NEPHROL, V29, P377, DOI 10.1007/s40620-015-0229-6
   Gruber HJ, 2008, INT J OBESITY, V32, P826, DOI 10.1038/sj.ijo.0803795
   Gumanova NG, 2019, EUR J CLIN INVEST, V49, DOI 10.1111/eci.13061
   Gumanova NG, 2017, INT ANGIOL, V36, P160, DOI 10.23736/S0392-9590.16.03674-9
   Gumanova NG, 2017, BIOFACTORS, V43, P82, DOI 10.1002/biof.1321
   Guo X, 2006, AM J PHYSIOL-HEART C, V291, pH2354, DOI 10.1152/ajpheart.00376.2006
   Habib SH, 2010, DIABETES METAB SYND, V4, P41, DOI 10.1016/j.dsx.2008.04.005
   Hadaegh F, 2016, NITRIC OXIDE-BIOL CH, V54, P60, DOI 10.1016/j.niox.2016.02.004
   Hayashi T, 2007, J AM GERIATR SOC, V55, P1398, DOI 10.1111/j.1532-5415.2007.01296.x
   Hendgen-Cotta UB, 2012, CIRCULATION, V126, P1983, DOI 10.1161/CIRCULATIONAHA.112.112912
   Hermann Matthias, 2006, J Clin Hypertens (Greenwich), V8, P17, DOI 10.1111/j.1524-6175.2006.06032.x
   Hewala TI, 2010, BRIT J BIOMED SCI, V67, P167, DOI 10.1080/09674845.2010.11730315
   Hezel M, 2016, FREE RADICAL BIO MED, V99, P87, DOI 10.1016/j.freeradbiomed.2016.07.025
   Higashi Y, 2003, J AM COLL CARDIOL, V42, P256, DOI 10.1016/S0735-1097(03)00630-2
   Higashino H., 2010, J MED SCI, V10, P1, DOI [10.3923/jms.2010.1.11, DOI 10.3923/JMS.2010.1.11]
   Higashino H, 2007, CLIN EXP PHARMACOL P, V34, P725, DOI 10.1111/j.1440-1681.2007.04617.x
   Hord NG, 2011, CURR ATHEROSCLER REP, V13, P484, DOI 10.1007/s11883-011-0209-9
   Hord NG, 2009, AM J CLIN NUTR, V90, P1, DOI 10.3945/ajcn.2008.27131
   Hozawa A, 2007, ARCH INTERN MED, V167, P573, DOI 10.1001/archinte.167.6.573
   Hu DH, 2014, EUR J PHARMACOL, V730, P41, DOI 10.1016/j.ejphar.2014.02.018
   IGNARRO LJ, 1989, FASEB J, V3, P31, DOI 10.1096/fasebj.3.1.2642868
   Jablecka A, 2012, EUR REV MED PHARMACO, V16, P342
   Jankovic A, 2017, BRIT J PHARMACOL, V174, P1570, DOI 10.1111/bph.13498
   Jeddi S, 2016, ARQ BRAS CARDIOL, V107, P339
   Jepson RE, 2008, J VET INTERN MED, V22, P317, DOI 10.1111/j.1939-1676.2008.0075.x
   Jilma B, 1996, LIFE SCI, V58, P469, DOI 10.1016/0024-3205(95)02311-9
   Jobgen WS, 2007, J CHROMATOGR B, V851, P71, DOI 10.1016/j.jchromb.2006.07.018
   Jobgen WS, 2006, J NUTR BIOCHEM, V17, P571, DOI 10.1016/j.jnutbio.2005.12.001
   Julinar REA, 2013, INT J PEDIAT ENDOCRI, V2013, P84
   Kagota S, 2006, LIFE SCI, V78, P1187, DOI 10.1016/j.lfs.2005.06.029
   Kapil V, 2014, NITRIC OXIDE-BIOL CH, V38, P45, DOI 10.1016/j.niox.2014.03.162
   Kapur S, 2000, INT J OBESITY, V24, pS36, DOI 10.1038/sj.ijo.0801502
   Kearney MT, 2013, DIABETES, V62, P1386, DOI 10.2337/db13-0183
   Kelm M, 1999, BBA-BIOENERGETICS, V1411, P273, DOI 10.1016/S0005-2728(99)00020-1
   Kerley CP, 2017, IRISH J MED SCI, V186, P895, DOI 10.1007/s11845-016-1551-2
   Khalifi S, 2015, NITRIC OXIDE-BIOL CH, V44, P24, DOI 10.1016/j.niox.2014.11.011
   Klahr S, 2001, NEPHROL DIAL TRANSPL, V16, P60, DOI 10.1093/ndt/16.suppl_1.60
   Knott AB, 2010, DIABETES OBES METAB, V12, P126, DOI 10.1111/j.1463-1326.2010.01267.x
   Kondo Takaaki, 2006, Environmental Health and Preventive Medicine, V11, P321, DOI 10.1007/BF02898023
   Korda M, 2008, AM J PHYSIOL-HEART C, V295, pH1514, DOI 10.1152/ajpheart.00479.2008
   Li RL, 2004, AM J HYPERTENS, V17, P560, DOI 10.1016/j.amjhyper.2004.02.013
   Lin LY, 2007, ATHEROSCLEROSIS, V190, P436, DOI 10.1016/j.atherosclerosis.2006.02.033
   Litvinova L, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00020
   Liu Hai-Ying, 2012, Zhonghua Liu Xing Bing Xue Za Zhi, V33, P746
   Lundberg JO, 2004, FREE RADICAL BIO MED, V37, P395, DOI 10.1016/j.freeradbiomed.2004.04.027
   Lundberg JO, 2005, ARTERIOSCL THROM VAS, V25, P915, DOI 10.1161/01.ATV.0000161048.72004.c2
   LUNDBERG JON, 1994, GUT, V35, P1543, DOI 10.1136/gut.35.11.1543
   Lundberg JO, 2008, NAT REV DRUG DISCOV, V7, DOI [10.1038/nrd2466-c2, 10.1038/nrd2466]
   Maas R, 2017, J AM HEART ASSOC, V6, DOI [10.1161/JAHA.117.004222, 10.1161/jaha.117.006224, 10.1161/JAHA.117.006224]
   Machha A, 2011, EUR J NUTR, V50, P293, DOI 10.1007/s00394-011-0192-5
   Makhzani P, 2017, ENDOCR RES, V42, P96, DOI 10.1080/07435800.2016.1197933
   Manju M, 2014, Int J Biomed Sci, V10, P252
   Gámez-Méndez AM, 2014, J NEPHROL, V27, P281, DOI 10.1007/s40620-013-0029-9
   Mariotti F, 2013, AM J CLIN NUTR, V97, P972, DOI 10.3945/ajcn.112.048025
   Masha A, 2011, CURR PHARM BIOTECHNO, V12, P1354, DOI 10.2174/138920111798281054
   Mastronardi CA, 2002, P NATL ACAD SCI USA, V99, P5721, DOI 10.1073/pnas.082098499
   Mazzone A, 2001, CLIN CHEM LAB MED, V39, P822, DOI 10.1515/CCLM.2001.136
   McGrowder D, 2006, J BIOSCIENCES, V31, P347, DOI 10.1007/BF02704107
   Meenakshi SR, 2013, J CLIN DIAGN RES, V7, P1288, DOI 10.7860/JCDR/2013/5972.3119
   Mendy A, 2018, CIRCULATION, V137, P2295, DOI 10.1161/CIRCULATIONAHA.118.034168
   Milkowski A, 2010, NITRIC OXIDE-BIOL CH, V22, P110, DOI 10.1016/j.niox.2009.08.004
   Miller GD, 2012, NUTR RES, V32, P160, DOI 10.1016/j.nutres.2012.02.002
   Miller VM, 1998, J CLIN PHARMACOL, V38, P22, DOI 10.1002/j.1552-4604.1998.tb04371.x
   Miranda KM, 2001, NITRIC OXIDE-BIOL CH, V5, P62, DOI 10.1006/niox.2000.0319
   Mirmiran P, 2016, RENAL FAILURE, V38, P937, DOI 10.3109/0886022X.2016.1165118
   Mirmiran P, 2016, NUTRIENTS, V8, DOI 10.3390/nu8050311
   Moncada S, 1997, ANN NY ACAD SCI, V811, P60, DOI 10.1111/j.1749-6632.1997.tb51989.x
   Muto S, 2017, ANTICANCER RES, V37, P3169, DOI 10.21873/anticanres.11676
   Nene S, 1997, J SURG RES, V71, P101, DOI 10.1006/jsre.1997.5147
   Oliveira-Paula GH, 2014, CURR DRUG TARGETS, V15, P164, DOI 10.2174/13894501113146660227
   Orange SJ, 2003, CLIN EXP PHARMACOL P, V30, P376, DOI 10.1046/j.1440-1681.2003.03844.x
   Osawa M, 2007, NITRIC OXIDE-BIOL CH, V16, P157, DOI 10.1016/j.niox.2006.06.002
   Owusu Darkwa Ebenezer, 2018, Matern Health Neonatol Perinatol, V4, P3, DOI 10.1186/s40748-017-0072-y
   Ozcelik O, 2017, CELL MOL BIOL, V63, P49, DOI 10.14715/cmb/2017.63.1.10
   Peinado MA, 2007, INT J CARDIOL, V121, P88, DOI 10.1016/j.ijcard.2006.08.032
   Pereira FO, 2006, MEDIAT INFLAMM, V2006, DOI 10.1155/MI/2006/39062
   Perreault M, 2001, NAT MED, V7, P1138, DOI 10.1038/nm1001-1138
   Petrie JR, 1996, CIRCULATION, V93, P1331, DOI 10.1161/01.CIR.93.7.1331
   Pham TNQ, 2003, J RHEUMATOL, V30, P2529
   PRYOR WA, 1995, AM J PHYSIOL-LUNG C, V268, pL699, DOI 10.1152/ajplung.1995.268.5.L699
   Reckelhoff JF, 1998, AM J HYPERTENS, V11, P97, DOI 10.1016/S0895-7061(97)00360-9
   Salimi S, 2010, 78 C EUR AN SOC, V11, P109
   Sansbury BE, 2014, VITAM HORM, V96, P323, DOI 10.1016/B978-0-12-800254-4.00013-1
   Sansbury BE, 2014, FREE RADICAL BIO MED, V73, P383, DOI 10.1016/j.freeradbiomed.2014.05.016
   Scherrer U, 2000, EUR J ENDOCRINOL, V142, P315, DOI 10.1530/eje.0.1420315
   Schmidt RJ, 2000, KIDNEY INT, V58, P1261, DOI 10.1046/j.1523-1755.2000.00281.x
   Schmidt RJ, 1999, AM J PHYSIOL-RENAL, V276, pF794, DOI 10.1152/ajprenal.1999.276.5.F794
   Seals DR, 2011, CLIN SCI, V120, P357, DOI 10.1042/CS20100476
   Shaamash AH, 2000, INT J GYNECOL OBSTET, V68, P207, DOI 10.1016/S0020-7292(99)00213-1
   Shahid SM, 2013, PAK J PHARM SCI, V26, P593
   Sikaris Kenneth A, 2014, Clin Biochem Rev, V35, P3
   Singh M, 2012, NITRIC OXIDE-BIOL CH, V26, P61, DOI 10.1016/j.niox.2011.12.002
   Stoclet JC, 1998, BIOCHEMISTRY-MOSCOW+, V63, P826
   TAKAHASHI H, 1992, J CARDIOVASC PHARM, V20, pS214, DOI 10.1097/00005344-199204002-00061
   Takase H, 2000, ARZNEIMITTELFORSCH, V50, P530
   Tangphao O, 1999, VASC MED, V4, P27
   Tehrani FR, 2015, ACTA OBSTET GYN SCAN, V94, P708, DOI 10.1111/aogs.12655
   Tehrani F, 2015, ARCH GYNECOL OBSTET, V291, P159, DOI 10.1007/s00404-014-3338-x
   Tessari P, 2010, DIABETES, V59, P2152, DOI 10.2337/db09-1772
   Toda N, 2011, J HYPERTENS, V29, P415, DOI 10.1097/HJH.0b013e328341d19e
   Toprakçi M, 2000, INT J CLIN LAB RES, V30, P83
   Tsikas D, 2005, FREE RADICAL RES, V39, P797, DOI 10.1080/10715760500053651
   Tsuchiya K, 2005, AM J PHYSIOL-HEART C, V288, pH2163, DOI 10.1152/ajpheart.00525.2004
   Tsuchiya M, 2002, CIRCULATION, V105, P1155, DOI 10.1161/hc1002.105935
   Tsukiyama Y, 2017, J CLIN BIOCHEM NUTR, V60, P180, DOI 10.3164/jcbn.16-108
   Vanizor B, 2001, DIABETES RES CLIN PR, V54, P33, DOI 10.1016/S0168-8227(01)00281-9
   Varzandi T, 2018, LIFE SCI, V207, P219, DOI 10.1016/j.lfs.2018.06.012
   Verma M, 2015, J SCI MED, V5, P4
   Waise A, 2009, ANN CLIN BIOCHEM, V46, P93, DOI 10.1258/acb.2008.008113
   Walford G, 2003, J THROMB HAEMOST, V1, P2112, DOI 10.1046/j.1538-7836.2003.00345.x
   Wang J, 1997, CLIN EXP PHARMACOL P, V24, P418, DOI 10.1111/j.1440-1681.1997.tb01212.x
   Wang J, 2017, J GERIATR CARDIOL, V14, P135, DOI 10.11909/j.issn.1671-5411.2017.02.008
   Wang Yushan, 2013, N Am J Med Sci (Boston), V6, P82
   Watanabe T, 2000, CLIN CHIM ACTA, V301, P169, DOI 10.1016/S0009-8981(00)00340-5
   Weitzberg E, 1998, NITRIC OXIDE-BIOL CH, V2, P1, DOI 10.1006/niox.1997.0162
   Weitzberg E, 2013, ANNU REV NUTR, V33, P129, DOI 10.1146/annurev-nutr-071812-161159
   Xu R, 2010, BMC NEPHROL, V11, DOI 10.1186/1471-2369-11-20
   Yoon Y, 2000, CLIN CHEM, V46, P1626
   Zavaroni I, 2000, METABOLISM, V49, P959, DOI 10.1053/meta.2000.7715
   Zeng Q-P, 2015, ARTEMISININ NITRIC O
   Zhang Shi-hui, 2011, Zhonghua Liu Xing Bing Xue Za Zhi, V32, P760
   Zhu SG, 2011, J AM COLL CARDIOL, V57, P2181, DOI 10.1016/j.jacc.2011.01.024
   Zweier JL, 1999, BBA-BIOENERGETICS, V1411, P250, DOI 10.1016/S0005-2728(99)00018-3
NR 188
TC 7
Z9 8
U1 0
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PD APR 3
PY 2019
VL 53
IS 4
BP 359
EP 376
DI 10.1080/10715762.2019.1587168
EA APR 2019
PG 18
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA IK9QD
UT WOS:000471420600001
PM 30821533
DA 2025-06-11
ER

PT J
AU Ouanes, S
   Castelao, E
   Gebreab, S
   von Gunten, A
   Preisig, M
   Popp, J
AF Ouanes, Sami
   Castelao, Enrique
   Gebreab, Sirak
   von Gunten, Armin
   Preisig, Martin
   Popp, Julius
TI Life events, salivary cortisol, and cognitive performance in nondemented
   subjects: a population-based study
SO NEUROBIOLOGY OF AGING
LA English
DT Article
DE Cognition; Life events; Cortisol; Memory; Dementia; Stress
ID CARDIOVASCULAR RISK-FACTORS; POSTTRAUMATIC-STRESS-DISORDER;
   ALZHEIMERS-DISEASE; OLDER-ADULTS; MEMORY PERFORMANCE; AWAKENING
   RESPONSE; METABOLIC SYNDROME; AMYLOID-BETA; DEMENTIA; DEPRESSION
AB Older people are particularly exposed to stressful events, known to activate the hypothalamus-pituitaryadrenal axis resulting in increased cortisol levels. High cortisol has been associated with deleterious effects on cognition. We hypothesized that stressful life events could increase cortisol secretion leading to cognitive impairment. A cross-sectional analysis was conducted using data from Colaus/PsyColaus, a longitudinal population-based study among Lausanne residents. Salivary cortisol samples were obtained from 796 nondemented subjects aged at least 65. A neuropsychological battery was used to assess cognitive performance and determine the Clinical Dementia Rating Sum of Boxes (CDRSOB). Lifetime life events and their subjective impact were assessed using a validated questionnaire. The total impact of life events was associated neither with cortisol area under the curve (AUC) nor with CDRSOB nor with any cognitive domain performance. The CDRSOB was associated with the cortisol AUC, controlling for age, sex, body mass index, education and depressive symptoms ( p = 0.003; B = 0.686 [ 0.240; 1.333]; r = 0.114). This association between CDRSOB and the cortisol AUC remained significant after controlling for life events total impact ( p = 0.040; B = 0.591 [ 0.027; 1.155]; r = 0.106). These findings do not support the hypothesis that stressful life events increase cortisol secretion leading to cognitive impairment. The association of higher cortisol levels with poorer cognition might be not a mere reflection of stressful events but rather explained by other factors, yet to be elucidated. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Ouanes, Sami; Castelao, Enrique; Gebreab, Sirak; von Gunten, Armin; Preisig, Martin; Popp, Julius] Univ Lausanne Hosp, Dept Psychiat, Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV)
RP Popp, J (corresponding author), Univ Lausanne Hosp, Dept Psychiat, Old Age Psychiat, Route Mt, CH-1008 Prilly, Switzerland.
EM julius.popp@chuv.ch
RI Preisig, Martin/H-3441-2016; Popp, Julius/IWM-3913-2023; Popp,
   Julius/ADG-7439-2022
OI Popp, Julius/0000-0002-0068-0312; Preisig, Martin/0000-0001-5689-4259;
   Ouanes, Sami/0000-0003-0867-060X; GEBREAB, SIRAK
   ZENEBE/0000-0001-5849-075X; Castelao, Enrique/0000-0003-1966-3683; von
   Gunten, Armin/0000-0001-7852-3803
FU GlaxoSmithKline; Faculty of Biology and Medicine of Lausanne; Swiss
   National Research Foundation [3200B0-105993, 3200B0-118308,
   33CSCO-122661, 33CS30139468, 33CS30-148401, 320030_141179];
   GlaxoSmithKline, the Faculty of Biology and Medicine of Lausanne; Swiss
   National Science Foundation (SNF) [33CS30_148401] Funding Source: Swiss
   National Science Foundation (SNF)
FX The authors would like to express their gratitude to the Lausanne
   inhabitants who volunteered to participate in the PsyCoLaus study. The
   authors would also like to thank all the investigators of the CoLaus
   study, which made the psychiatric PsyCoLaus study possible. The
   CoLaus/PsyCoLaus study was and is supported by research grants from
   GlaxoSmithKline, the Faculty of Biology and Medicine of Lausanne, and
   the Swiss National Research Foundation (grants 3200B0-105993,
   3200B0-118308, 33CSCO-122661, 33CS30139468 and 33CS30-148401). Julius
   Popp received support from the Swiss National Research Foundation (grant
   320030_141179).
CR Aartsen MJ, 2005, PSYCHOL MED, V35, P217, DOI 10.1017/S0033291704002831
   Amiel-Lebigre F., 2004, EMC PSYCHIAT, V1, P75
   [Anonymous], 1997, DO 80 EPREUVE DENOMI
   Anterion CT, 2003, ANN GERONTOLOGIQUE, P56
   Buschke H, 1997, NEUROLOGY, V48, P989, DOI 10.1212/WNL.48.4.989
   Byers AL, 2011, NAT REV NEUROL, V7, P323, DOI 10.1038/nrneurol.2011.60
   Comijs HC, 2011, J GERONTOL B-PSYCHOL, V66, P111, DOI 10.1093/geronb/gbr019
   Csernansky JG, 2006, AM J PSYCHIAT, V163, P2164, DOI 10.1176/appi.ajp.163.12.2164
   Daskalakis NP, 2013, ENDOCRIN METAB CLIN, V42, P503, DOI 10.1016/j.ecl.2013.05.004
   de Kloet ER, 1999, TRENDS NEUROSCI, V22, P422, DOI 10.1016/S0166-2236(99)01438-1
   de Quervain DJF, 1998, NATURE, V394, P787, DOI 10.1038/29542
   Deeg DJH, 2005, EUR J PUBLIC HEALTH, V15, P170, DOI 10.1093/eurpub/cki126
   Firmann M, 2008, BMC CARDIOVASC DISOR, V8, DOI 10.1186/1471-2261-8-6
   Fountoulakis KN, 2011, PSYCHIAT RES, V190, P156, DOI 10.1016/j.psychres.2011.05.011
   Gallagher P, 2006, J PSYCHOPHARMACOL, V20, P643, DOI 10.1177/0269881106060585
   Garrido P, 2011, AGING DIS, V2, P80
   Geerlings MI, 2015, NEUROLOGY, V85, P976, DOI 10.1212/WNL.0000000000001931
   Goodman YD, 1996, J NEUROCHEM, V66, P1836
   Green KN, 2006, J NEUROSCI, V26, P9047, DOI 10.1523/JNEUROSCI.2797-06.2006
   Hampson E, 2016, PSYCHONEUROENDOCRINO, V64, P99, DOI 10.1016/j.psyneuen.2015.11.009
   Hidalgo V, 2016, PSYCHONEUROENDOCRINO, V71, P136, DOI 10.1016/j.psyneuen.2016.05.019
   Johansson L, 2012, PSYCHOSOM MED, V74, P120, DOI 10.1097/PSY.0b013e318246eb10
   Johansson L, 2010, BRAIN, V133, P2217, DOI 10.1093/brain/awq116
   Kim B, 2015, EXP MOL MED, V47, DOI 10.1038/emm.2015.3
   Koolhaas JM, 1999, NEUROSCI BIOBEHAV R, V23, P925, DOI 10.1016/S0149-7634(99)00026-3
   Kuehner C, 2007, PSYCHONEUROENDOCRINO, V32, P199, DOI 10.1016/j.psyneuen.2006.12.007
   Lara VP, 2016, J CLIN LAB ANAL, V30, P374, DOI 10.1002/jcla.21865
   Lee CMY, 2008, J CLIN EPIDEMIOL, V61, P646, DOI 10.1016/j.jclinepi.2007.08.012
   Li G, 2006, NEUROBIOL AGING, V27, P1705, DOI 10.1016/j.neurobiolaging.2005.09.031
   LUPIEN S, 1994, J NEUROSCI, V14, P2893, DOI 10.1523/jneurosci.14-05-02893.1994
   Lupien SJ, 2007, BRAIN COGNITION, V65, P209, DOI 10.1016/j.bandc.2007.02.007
   McEwen BS, 2007, PHYSIOL REV, V87, P873, DOI 10.1152/physrev.00041.2006
   Miller GE, 2007, PSYCHOL BULL, V133, P25, DOI 10.1037/0033-2909.133.1.25
   Morin AJS, 2011, REV EPIDEMIOL SANTE, V59, P327, DOI 10.1016/j.respe.2011.03.061
   MORRIS JC, 1993, NEUROLOGY, V43, P2412, DOI 10.1212/WNL.43.11.2412-a
   MORRIS JC, 1988, PSYCHOPHARMACOL BULL, V24, P641
   Murialdo G, 2000, J ENDOCRINOL INVEST, V23, P178, DOI 10.1007/BF03343703
   Odeniyi IA, 2015, NIGER J CLIN PRACT, V18, P194, DOI 10.4103/1119-3077.151040
   Peavy GM, 2009, AM J PSYCHIAT, V166, P1384, DOI 10.1176/appi.ajp.2009.09040461
   Persson G, 1996, INT J GERIATR PSYCH, V11, P15, DOI 10.1002/(SICI)1099-1166(199601)11:1<15::AID-GPS262>3.0.CO;2-5
   Popp J, 2009, NEUROBIOL AGING, V30, P498, DOI 10.1016/j.neurobiolaging.2007.07.007
   Preisig M, 1999, EUR ARCH PSY CLIN N, V249, P174, DOI 10.1007/s004060050084
   Preisig M, 2009, BMC PSYCHIATRY, V9, DOI 10.1186/1471-244X-9-9
   Pruessner JC, 2003, PSYCHONEUROENDOCRINO, V28, P916, DOI 10.1016/S0306-4530(02)00108-7
   Rosnick CB, 2007, J AGING HEALTH, V19, P612, DOI 10.1177/0898264307300975
   Stalder T, 2016, PSYCHONEUROENDOCRINO, V63, P414, DOI 10.1016/j.psyneuen.2015.10.010
   Sundström A, 2014, INT PSYCHOGERIATR, V26, P147, DOI 10.1017/S1041610213001804
   Takahashi T, 2004, NEUROSCI LETT, V363, P125, DOI 10.1016/j.neulet.2004.03.062
   Tatomir Alexandru, 2014, Clujul Med, V87, P3, DOI 10.15386/cjm.2014.8872.871.at1cm2
   van Gelder BM, 2006, J GERONTOL B-PSYCHOL, V61, pP213, DOI 10.1093/geronb/61.4.P213
   Vogel S, 2016, TRENDS COGN SCI, V20, P192, DOI 10.1016/j.tics.2015.12.003
   VonDras DD, 2005, AGING MENT HEALTH, V9, P60, DOI 10.1080/13607860412331323782
   Ward L, 2007, GERONTOLOGY, V53, P362, DOI 10.1159/000104787
   Wingenfeld K, 2015, PSYCHONEUROENDOCRINO, V51, P282, DOI 10.1016/j.psyneuen.2014.10.009
   Xavier FMF, 2002, J CLIN EXP NEUROPSYC, V24, P294, DOI 10.1076/jcen.24.3.294.983
NR 55
TC 36
Z9 37
U1 0
U2 23
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0197-4580
EI 1558-1497
J9 NEUROBIOL AGING
JI Neurobiol. Aging
PD MAR
PY 2017
VL 51
BP 1
EP 8
DI 10.1016/j.neurobiolaging.2016.11.014
PG 8
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA EP1UA
UT WOS:000397168600001
PM 28012996
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chiang, JJ
   Ko, A
   Bower, JE
   Taylor, SE
   Irwin, MR
   Fuligni, AJ
AF Chiang, Jessica J.
   Ko, Ahra
   Bower, Julienne E.
   Taylor, Shelley E.
   Irwin, Michael R.
   Fuligni, Andrew J.
TI Stress, Psychological Resources, and HPA and Inflammatory Reactivity
   During Late Adolescence
SO DEVELOPMENT AND PSYCHOPATHOLOGY
LA English
DT Article
ID CHILDHOOD SOCIOECONOMIC-STATUS; PITUITARY-ADRENOCORTICAL AXIS;
   SHIFT-AND-PERSIST; CORTISOL RESPONSES; FAMILY STRESS; PROINFLAMMATORY
   PHENOTYPE; INDIVIDUAL-DIFFERENCES; AMERICAN ADOLESCENTS; METABOLIC
   SYNDROME; SALIVARY CORTISOL
AB Psychosocial stress during childhood and adolescence is associated with alterations in the hypothalamic-pituitary-adrenal (HPA) axis and with heightened inflammation, both of which are implicated in poor health; however, factors that may protect against these effects relatively early in life are not well understood. Thus, we examined whether psychosocial resources protect against stress-related alterations in the HPA axis and heightened inflammation in a sample of 91 late adolescents. Participants completed measures of various stressors (major life events, daily interpersonal stress, early adversity), and psychosocial resources (mastery, optimism, self-esteem, and positive reappraisal). They also completed the Trier Social Stress Test and provided saliva and blood samples for the assessment of cortisol and interleukin-6 reactivity. Each of the stressors was associated with lower cortisol reactivity. Additionally, associations with major life events and daily stress were moderated by psychological resources, such that more life events and daily stress were associated with decreased HPA reactivity among adolescents with lower levels of psychological resources, but not among those with higher levels of psychological resources. This pattern of findings was observed only for cortisol reactivity and not for interleukin-6 reactivity. Findings suggest that psychological resources may counteract the effects of certain adversity-related decreases in cortisol reactivity.
C1 [Chiang, Jessica J.] Northwestern Univ, 1801 Maple Ave,Suite 2450, Evanston, IL 60201 USA.
   [Ko, Ahra] Los Angeles Cty Dept Mental Hlth, Los Angeles, CA USA.
   [Bower, Julienne E.; Taylor, Shelley E.; Irwin, Michael R.; Fuligni, Andrew J.] Univ Calif Los Angeles, Los Angeles, CA 90024 USA.
C3 Northwestern University; University of California System; University of
   California Los Angeles
RP Chiang, JJ (corresponding author), Northwestern Univ, 1801 Maple Ave,Suite 2450, Evanston, IL 60201 USA.
EM jessica.chiang@northwestern.edu
RI Irwin, Michael/H-4870-2013
OI Irwin, Michael/0000-0002-1502-8431
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development [R01HD062547]; UCLA California Center for Population
   Research - National Institute of Child Health and Human Development
   [R24HD041022]; UCLA Older Americans Independence Center - National
   Institute of Aging [P30-AG028748]; UCLA Cousins Center for
   Psychoneuroimmunology; University of California Institute for Mexico;
   US, American Psychological Association; Division 38 of the American
   Psychological Association; National Heart, Lung, and Blood Institute
   Grant [F32-HL134276]
FX This research was supported by funding from the Eunice Kennedy Shriver
   National Institute of Child Health and Human Development (R01HD062547),
   UCLA California Center for Population Research funded by the National
   Institute of Child Health and Human Development (R24HD041022), and the
   UCLA Older Americans Independence Center funded by the National
   Institute of Aging (P30-AG028748), UCLA Cousins Center for
   Psychoneuroimmunology, University of California Institute for Mexico and
   the US, American Psychological Association, and Division 38 of the
   American Psychological Association. The authors' efforts were supported
   by the National Heart, Lung, and Blood Institute Grant F32-HL134276 (to
   J.J.C.).
CR [Anonymous], 2014, Stress in America: Are teens adopting adults' stress habits?
   [Anonymous], 2011, Tools for Change, V1, P1
   [Anonymous], 2017, GASTRIC CANCER, V1, P1, DOI DOI 10.1007/S10120-016-0622-4
   [Anonymous], 2014, JOURNAL OF THE AMERI, V3, pA1
   Baumeister D, 2016, MOL PSYCHIATR, V21, P642, DOI 10.1038/mp.2015.67
   Black PH, 2003, BRAIN BEHAV IMMUN, V17, P350, DOI 10.1016/S0889-1591(03)00048-5
   Blakemore SJ, 2014, ANNU REV PSYCHOL, V65, P187, DOI 10.1146/annurev-psych-010213-115202
   Boylan JM, 2016, HEALTH PSYCHOL, V35, P957, DOI 10.1037/hea0000355
   Brody GH, 2016, DEV PSYCHOPATHOL, V28, P1347, DOI 10.1017/S0954579416000894
   Brown DW, 2009, AM J PREV MED, V37, P389, DOI 10.1016/j.amepre.2009.06.021
   Brydon L, 2005, J HYPERTENS, V23, P1001, DOI 10.1097/01.hjh.0000166841.57474.d0
   Bunea IM, 2017, TRANSL PSYCHIAT, V7, DOI 10.1038/s41398-017-0032-3
   Carnuta M, 2015, PSYCHONEUROENDOCRINO, V51, P176, DOI 10.1016/j.psyneuen.2014.09.026
   Carpenter LL, 2007, BIOL PSYCHIAT, V62, P1080, DOI 10.1016/j.biopsych.2007.05.002
   Carpenter LL, 2011, PSYCHOPHARMACOLOGY, V214, P367, DOI 10.1007/s00213-010-2007-4
   Carroll D, 2012, PSYCHOPHYSIOLOGY, V49, P866, DOI 10.1111/j.1469-8986.2012.01361.x
   Carroll JE, 2013, P NATL ACAD SCI USA, V110, P17149, DOI 10.1073/pnas.1315458110
   Carver CS, 2010, CLIN PSYCHOL REV, V30, P879, DOI 10.1016/j.cpr.2010.01.006
   Chen E, 2011, MOL PSYCHIATR, V16, P729, DOI 10.1038/mp.2010.53
   Chen E, 2015, PSYCHOSOM MED, V77, P371, DOI 10.1097/PSY.0000000000000157
   Chen E, 2013, CHILD DEV, V84, P1241, DOI 10.1111/cdev.12037
   Chen E, 2013, ANNU REV CLIN PSYCHO, V9, P723, DOI 10.1146/annurev-clinpsy-050212-185634
   Chiang JJ, 2018, NAT HUM BEHAV, V2, P261, DOI 10.1038/s41562-018-0316-5
   Chiang JJ, 2017, BRAIN BEHAV IMMUN, V66, P146, DOI 10.1016/j.bbi.2017.06.015
   Chiang JJ, 2016, PSYCHONEUROENDOCRINO, V71, P43, DOI 10.1016/j.psyneuen.2016.05.009
   Chiang JJ, 2015, DEV PSYCHOBIOL, V57, P887, DOI 10.1002/dev.21329
   Chiang JJ, 2012, P NATL ACAD SCI USA, V109, P1878, DOI 10.1073/pnas.1120972109
   Choy E, 2012, RHEUMATOLOGY, V51, pV3, DOI 10.1093/rheumatology/kes113
   Chung GH, 2009, DEV PSYCHOL, V45, P1406, DOI 10.1037/a0014163
   Coelho R, 2014, ACTA PSYCHIAT SCAND, V129, P180, DOI 10.1111/acps.12217
   Cohen S, 2004, PSYCHOSOM MED, V66, P553, DOI 10.1097/01.psy.0000126200.05189.d3
   Conger RD, 2002, DEV PSYCHOL, V38, P179, DOI 10.1037/0012-1649.38.2.179
   de Rooij SR, 2013, INT J PSYCHOPHYSIOL, V90, P21, DOI 10.1016/j.ijpsycho.2012.09.011
   Del Giudice M, 2011, NEUROSCI BIOBEHAV R, V35, P1562, DOI 10.1016/j.neubiorev.2010.11.007
   DELONGIS A, 1988, J PERS SOC PSYCHOL, V54, P486, DOI 10.1037/0022-3514.54.3.486
   Demakakos P, 2016, BRIT J PSYCHIAT, V209, P135, DOI 10.1192/bjp.bp.115.163543
   DeSantis AS, 2007, J ADOLESCENT HEALTH, V41, P3, DOI 10.1016/j.jadohealth.2007.03.006
   Dickerson SS, 2004, PSYCHOL BULL, V130, P355, DOI 10.1037/0033-2909.130.3.355
   Dietz LJ, 2013, BIOL PSYCHIAT, V73, P379, DOI 10.1016/j.biopsych.2012.08.016
   Dowd JB, 2009, INT J EPIDEMIOL, V38, P1297, DOI 10.1093/ije/dyp277
   Ehrlich K.B., 2016, Developmental Psychopathology, V3rd, P1
   El-Farhan N, 2017, ANN CLIN BIOCHEM, V54, P308, DOI 10.1177/0004563216687335
   Elinav E, 2013, NAT REV CANCER, V13, P759, DOI 10.1038/nrc3611
   Elliot AJ, 2016, HEALTH PSYCHOL, V35, P1205, DOI 10.1037/hea0000392
   Elzinga BM, 2008, PSYCHONEUROENDOCRINO, V33, P227, DOI 10.1016/j.psyneuen.2007.11.004
   Engert V, 2010, J PSYCHIATR NEUROSCI, V35, P370, DOI 10.1503/jpn.100022
   Fries E, 2005, PSYCHONEUROENDOCRINO, V30, P1010, DOI 10.1016/j.psyneuen.2005.04.006
   Fuligni AJ, 1999, CHILD DEV, V70, P1030, DOI 10.1111/1467-8624.00075
   Fuligni AJ, 2009, PSYCHOSOM MED, V71, P329, DOI 10.1097/PSY.0b013e3181921b1f
   Gallo LC, 2009, CURR DIR PSYCHOL SCI, V18, P269, DOI 10.1111/j.1467-8721.2009.01650.x
   Gouin JP, 2017, ANN BEHAV MED, V51, P782, DOI 10.1007/s12160-017-9891-3
   Greene ML, 2006, DEV PSYCHOL, V42, P218, DOI 10.1037/0012-1649.42.2.218
   Gross JJ, 2003, J PERS SOC PSYCHOL, V85, P348, DOI 10.1037/0022-3514.85.2.348
   Grzywacz JG, 2002, FAM RELAT, V51, P28, DOI 10.1111/j.1741-3729.2002.00028.x
   Gunnar M, 2007, ANNU REV PSYCHOL, V58, P145, DOI 10.1146/annurev.psych.58.110405.085605
   Gunnar MR, 2009, DEV PSYCHOPATHOL, V21, P69, DOI 10.1017/S0954579409000054
   HAMMEN C, 1991, J ABNORM PSYCHOL, V100, P555, DOI 10.1037/0021-843X.100.4.555
   Heim C, 2000, PSYCHONEUROENDOCRINO, V25, P1, DOI 10.1016/S0306-4530(99)00035-9
   Heim C, 2012, EXP NEUROL, V233, P102, DOI 10.1016/j.expneurol.2011.10.032
   Hostinar CE, 2014, PSYCHOL BULL, V140, P256, DOI 10.1037/a0032671
   Irwin MR, 2011, NAT REV IMMUNOL, V11, P625, DOI 10.1038/nri3042
   Jacks DE, 2002, J STRENGTH COND RES, V16, P286, DOI 10.1519/00124278-200205000-00018
   Janusek LW, 2017, BRAIN BEHAV IMMUN, V60, P126, DOI 10.1016/j.bbi.2016.10.006
   Kallem S, 2013, OBESITY, V21, P1759, DOI 10.1002/oby.20195
   KIRSCHBAUM C, 1993, NEUROPSYCHOBIOLOGY, V28, P76, DOI 10.1159/000119004
   Kraft AJ, 2009, PSYCHONEUROENDOCRINO, V34, P1363, DOI 10.1016/j.psyneuen.2009.04.008
   Libby P, 2006, AM J CLIN NUTR, V83, p456S
   Loucks EB, 2011, PSYCHOSOM MED, V73, P563, DOI 10.1097/PSY.0b013e318228c820
   Lovallo WR, 2013, INT J PSYCHOPHYSIOL, V90, P8, DOI 10.1016/j.ijpsycho.2012.10.006
   Lovallo WR, 2005, PSYCHOSOM MED, V67, P734, DOI 10.1097/01.psy.0000181270.20036.06
   Luecken LJ, 2006, DEV PSYCHOPATHOL, V18, P295, DOI 10.1017/S0954579406060160
   Lundgren O, 2015, INT J BEHAV MED, V22, P77, DOI 10.1007/s12529-014-9387-5
   MacMillan HL, 2009, BIOL PSYCHIAT, V66, P62, DOI 10.1016/j.biopsych.2008.12.014
   Marsland AL, 2017, BRAIN BEHAV IMMUN, V64, P208, DOI 10.1016/j.bbi.2017.01.011
   McEwen BS, 1999, ANN NY ACAD SCI, V896, P30, DOI 10.1111/j.1749-6632.1999.tb08103.x
   Miller GE, 2007, PSYCHOL BULL, V133, P25, DOI 10.1037/0033-2909.133.1.25
   Miller GE, 2011, PSYCHOL BULL, V137, P959, DOI 10.1037/a0024768
   Miller GE, 2010, PSYCHOL SCI, V21, P848, DOI 10.1177/0956797610370161
   Miller GE, 2009, P NATL ACAD SCI USA, V106, P14716, DOI 10.1073/pnas.0902971106
   Nishina A, 2005, CHILD DEV, V76, P435, DOI 10.1111/j.1467-8624.2005.00855.x
   O'Connor MF, 2009, BRAIN BEHAV IMMUN, V23, P887, DOI 10.1016/j.bbi.2009.04.005
   PEARLIN LI, 1978, J HEALTH SOC BEHAV, V19, P2, DOI 10.2307/2136319
   Phillips AC, 2005, PSYCHOPHYSIOLOGY, V42, P232, DOI 10.1111/j.1469-8986.2005.00281.x
   Pyykkönen AJ, 2010, DIABETES CARE, V33, P378, DOI 10.2337/dc09-1027
   Repetti RL, 2011, DEV PSYCHOPATHOL, V23, P921, DOI 10.1017/S095457941100040X
   Repetti RL, 2002, PSYCHOL BULL, V128, P330, DOI 10.1037/0033-2909.128.2.330
   Rohleder N, 2014, PSYCHOSOM MED, V76, P181, DOI 10.1097/PSY.0000000000000049
   Rosenberg M., 1965, Society and the adolescent self-image, DOI [DOI 10.1515/9781400876136, 10.1515/9781400876136]
   SABOGAL F, 1987, HISPANIC J BEHAV SCI, V9, P397, DOI 10.1177/07399863870094003
   SCHEIER MF, 1994, J PERS SOC PSYCHOL, V67, P1063, DOI 10.1037/0022-3514.67.6.1063
   Sebastian C, 2010, BRAIN COGNITION, V72, P134, DOI 10.1016/j.bandc.2009.06.008
   Semega J.L., 2017, INCOME POVERTY US 20
   Sin NL, 2015, HEALTH PSYCHOL, V34, P1154, DOI 10.1037/hea0000240
   Slavich GM, 2014, PSYCHOL BULL, V140, P774, DOI 10.1037/a0035302
   Slopen N, 2013, PSYCHONEUROENDOCRINO, V38, P188, DOI 10.1016/j.psyneuen.2012.05.013
   Slopen N, 2012, BRAIN BEHAV IMMUN, V26, P239, DOI 10.1016/j.bbi.2011.11.003
   Somerville LH, 2013, CURR DIR PSYCHOL SCI, V22, P121, DOI 10.1177/0963721413476512
   Spear LP, 2009, DEV PSYCHOPATHOL, V21, P87, DOI 10.1017/S0954579409000066
   Stamatakis KA, 2004, ANN EPIDEMIOL, V14, P58, DOI 10.1016/S1047-2797(03)00078-4
   Stawski RS, 2013, PSYCHONEUROENDOCRINO, V38, P2654, DOI 10.1016/j.psyneuen.2013.06.023
   Steptoe A, 2007, BRAIN BEHAV IMMUN, V21, P901, DOI 10.1016/j.bbi.2007.03.011
   STONE AA, 1994, HEALTH PSYCHOL, V13, P440, DOI 10.1037/0278-6133.13.5.440
   Stroud CB, 2016, DEV PSYCHOBIOL, V58, P700, DOI 10.1002/dev.21410
   Stroud LR, 2009, DEV PSYCHOPATHOL, V21, P47, DOI 10.1017/S0954579409000042
   Surtees PG, 2006, HEALTH PSYCHOL, V25, P102, DOI 10.1037/0278-6133.25.1.102
   Taylor SE, 2004, J PERS, V72, P1365, DOI 10.1111/j.1467-6494.2004.00300.x
   Taylor SE, 1999, ANN NY ACAD SCI, V896, P210, DOI 10.1111/j.1749-6632.1999.tb08117.x
   Taylor SE, 2007, ANNU REV CLIN PSYCHO, V3, P377, DOI 10.1146/annurev.clinpsy.3.022806.091520
   Tottenham N, 2016, NEUROSCI BIOBEHAV R, V70, P217, DOI 10.1016/j.neubiorev.2016.07.030
   Uhart M, 2006, PSYCHONEUROENDOCRINO, V31, P642, DOI 10.1016/j.psyneuen.2006.02.003
   Viner RM, 2012, LANCET, V379, P1641, DOI 10.1016/S0140-6736(12)60149-4
   Wellen KE, 2005, J CLIN INVEST, V115, P1111, DOI 10.1172/JCI200525102
NR 112
TC 29
Z9 30
U1 2
U2 22
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0954-5794
EI 1469-2198
J9 DEV PSYCHOPATHOL
JI Dev. Psychopathol.
PD MAY
PY 2019
VL 31
IS 2
BP 699
EP 712
DI 10.1017/S0954579418000287
PG 14
WC Psychology, Developmental
WE Social Science Citation Index (SSCI)
SC Psychology
GA HV9ZY
UT WOS:000466341900022
PM 30079845
OA Green Accepted, Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Yan, LJ
AF Yan, Liang-Jun
TI Pathogenesis of Chronic Hyperglycemia: From Reductive Stress to
   Oxidative Stress
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Review
ID BETA-N-ACETYLGLUCOSAMINE; REACTIVE OXYGEN; INSULIN-RESISTANCE; ALDOSE
   REDUCTASE; POLYOL PATHWAY; HIGH-GLUCOSE; SUPEROXIDE-PRODUCTION;
   DIABETES-MELLITUS; O-GLCNACYLATION; GLYCERALDEHYDE-3-PHOSPHATE
   DEHYDROGENASE
AB Chronic overnutrition creates chronic hyperglycemia that can gradually induce insulin resistance and insulin secretion impairment. These disorders, if not intervened, will eventually be followed by appearance of frank diabetes. The mechanisms of this chronic pathogenic process are complex but have been suggested to involve production of reactive oxygen species (ROS) and oxidative stress. In this review, I highlight evidence that reductive stress imposed by overflux of NADH through the mitochondrial electron transport chain is the source of oxidative stress, which is based on establishments that more NADH recycling by mitochondrial complex I leads to more electron leakage and thus more ROS production. The elevated levels of both NADH and ROS can inhibit and inactivate glyceraldehyde 3-phosphate dehydrogenase (GAPDH), respectively, resulting in blockage of the glycolytic pathway and accumulation of glycerol 3-phospate and its prior metabolites along the pathway. This accumulation then initiates all those alternative glucose metabolic pathways such as the polyol pathway and the advanced glycation pathways that otherwise are minor and insignificant under euglycemic conditions. Importantly, all these alternative pathways lead to ROS production, thus aggravating cellular oxidative stress. Therefore, reductive stress followed by oxidative stress comprises a major mechanism of hyperglycemia-induced metabolic syndrome.
C1 Univ N Texas, Hlth Sci Ctr, UNT Syst Coll Pharm, Dept Pharmaceut Sci, Ft Worth, TX 76107 USA.
C3 University of North Texas System; University of North Texas Health
   Science Center
RP Yan, LJ (corresponding author), Univ N Texas, Hlth Sci Ctr, UNT Syst Coll Pharm, Dept Pharmaceut Sci, 3500 Camp Bowie Blvd,RES-314E, Ft Worth, TX 76107 USA.
EM liang-jun.yan@unthsc.edu
OI Yan, Liang-Jun/0000-0002-5815-5430
FU National Institute of Neurological Disorders and Stroke [R01NS079792]
FX Liang-Jun Yan is supported in part by a Grant from the National
   Institute of Neurological Disorders and Stroke (R01NS079792).
CR Abdul-Ghani MA, 2010, J BIOMED BIOTECHNOL, DOI 10.1155/2010/476279
   Abdul-Ghani Muhammad A., 2008, P191, DOI 10.1007/978-1-59745-420-9_11
   [Anonymous], J BIOL CHEM
   [Anonymous], 2002, ENDOCRINOL ROUNDS
   Arora MK, 2014, CURR DRUG TARGETS, V15, P531, DOI 10.2174/1389450115666140321120635
   Bandeira SD, 2013, INT J MOL SCI, V14, P3265, DOI 10.3390/ijms14023265
   Bánhegyi G, 2008, J NEUROCHEM, V107, P20, DOI 10.1111/j.1471-4159.2008.05571.x
   Barnett A., 2012, TYPE 2 DIABETES
   Bassi R, 2012, EXP DIABETES RES, DOI 10.1155/2012/916560
   Bensellam M, 2012, MOL CELL ENDOCRINOL, V364, P1, DOI 10.1016/j.mce.2012.08.003
   Bey EA, 2004, J IMMUNOL, V173, P5730, DOI 10.4049/jimmunol.173.9.5730
   Bocci V, 2014, DIABETES METAB SYND, V8, P57, DOI 10.1016/j.dsx.2013.10.004
   Brownlee M, 2001, NATURE, V414, P813, DOI 10.1038/414813a
   Brownlee M, 2005, DIABETES, V54, P1615, DOI 10.2337/diabetes.54.6.1615
   Butler AE, 2003, DIABETES, V52, P102, DOI 10.2337/diabetes.52.1.102
   Cai DS, 2013, TRENDS ENDOCRIN MET, V24, P40, DOI 10.1016/j.tem.2012.11.003
   Cai Zhiyou, 2013, J Biochem Pharmacol Res, V1, P15
   Callaghan MJ, 2005, ANTIOXID REDOX SIGN, V7, P1476, DOI 10.1089/ars.2005.7.1476
   CAMERON NE, 1994, DIABETES METAB REV, V10, P189, DOI 10.1002/dmr.5610100302
   Ceriello A, 2003, DIABETES CARE, V26, P1589, DOI 10.2337/diacare.26.5.1589
   Ceriello A, 2005, DIABETES, V54, P1, DOI 10.2337/diabetes.54.1.1
   Cernea S, 2013, BIOCHEM MEDICA, V23, P266
   Chiu J, 2008, CAN J PHYSIOL PHARM, V86, P365, DOI 10.1139/Y08-033
   Davidson MB, 2005, NAT REV DRUG DISCOV, V4, P713, DOI 10.1038/nrd1828
   DAWSON TL, 1993, AM J PHYSIOL, V264, pC961, DOI 10.1152/ajpcell.1993.264.4.C961
   Dedoussis George V Z, 2007, Rev Diabet Stud, V4, P13, DOI 10.1900/RDS.2007.4.13
   DEFRONZO R A, 1987, Diabetes Metabolism Reviews, V3, P415
   DeFronzo RA, 1997, NETH J MED, V50, P191, DOI 10.1016/S0300-2977(97)00012-0
   DeFronzo RA, 2004, MED CLIN N AM, V88, P787, DOI 10.1016/j.mcna.2004.04.013
   Del Prato S, 2009, DIABETIC MED, V26, P1185, DOI 10.1111/j.1464-5491.2009.02847.x
   Dröse S, 2012, ADV EXP MED BIOL, V748, P145, DOI 10.1007/978-1-4614-3573-0_6
   Du XL, 2003, J CLIN INVEST, V112, P1049, DOI 10.1172/JCI200318127
   Dunlop M, 2000, KIDNEY INT, V58, pS3, DOI 10.1046/j.1523-1755.2000.07702.x
   Eiselein L, 2004, ILAR J, V45, P231, DOI 10.1093/ilar.45.3.231
   Esposti MD, 1996, DIABETES, V45, P1531, DOI 10.2337/diabetes.45.11.1531
   Esterházy D, 2008, BIOCHEMISTRY-US, V47, P3964, DOI 10.1021/bi702243b
   Fardini Y, 2014, FASEB J, V28, P1010, DOI 10.1096/fj.13-238378
   Farhana A, 2010, ADV MICROB PHYSIOL, V57, P43, DOI 10.1016/B978-0-12-381045-8.00002-3
   Feng B, 2013, CAN J PHYSIOL PHARM, V91, P213, DOI 10.1139/cjpp-2012-0251
   Fiorentino TV, 2013, CURR PHARM DESIGN, V19, P5695, DOI 10.2174/1381612811319320005
   Fisher-Wellman KH, 2012, TRENDS ENDOCRIN MET, V23, P142, DOI 10.1016/j.tem.2011.12.008
   Fontayne A, 2002, BIOCHEMISTRY-US, V41, P7743, DOI 10.1021/bi011953s
   Forbes JM, 2013, PHYSIOL REV, V93, P137, DOI 10.1152/physrev.00045.2011
   Funk SD, 2012, INT J VASC MED, V2012, DOI 10.1155/2012/569654
   GABBAY KH, 1973, NEW ENGL J MED, V288, P831, DOI 10.1056/NEJM197304192881609
   Gerich JE, 2001, DIABETES CARE, V24, P382, DOI 10.2337/diacare.24.2.382
   GERICH JE, 1993, BAILLIERE CLIN ENDOC, V7, P551, DOI 10.1016/S0950-351X(05)80207-1
   Gholap NN, 2013, BRIT J GEN PRACT, V63, pE165, DOI 10.3399/bjgp13X663244
   Ghyczy M, 2001, BRIT J NUTR, V85, P409, DOI 10.1079/BJN2000274
   Giacco F, 2010, CIRC RES, V107, P1058, DOI 10.1161/CIRCRESAHA.110.223545
   Goldberg H, 2011, AM J PHYSIOL-ENDOC M, V301, pE713, DOI 10.1152/ajpendo.00108.2011
   Gomes AP, 2013, CELL, V155, P1624, DOI 10.1016/j.cell.2013.11.037
   Gupta D, 2012, CURR DIABETES REV, V8, P76, DOI 10.2174/157339912799424564
   Gurel Z, 2013, MOL VIS, V19, P1047
   Hayden Melvin R, 2002, JOP, V3, P86
   He Q, 2013, INT J BIOCHEM CELL B, V45, P2749, DOI 10.1016/j.biocel.2013.09.011
   HEAGERTY AM, 1993, HYPERTENSION, V21, P391, DOI 10.1161/01.HYP.21.4.391
   Henriksen EJ, 2011, FREE RADICAL BIO MED, V51, P993, DOI 10.1016/j.freeradbiomed.2010.12.005
   Hirst J, 2008, BIOCHEM SOC T, V36, P976, DOI 10.1042/BST0360976
   Hirst J, 2013, ANNU REV BIOCHEM, V82, P551, DOI 10.1146/annurev-biochem-070511-103700
   Hwang NR, 2009, BIOCHEM J, V423, P253, DOI 10.1042/BJ20090854
   Hwang YYC, 2003, FASEB J, V17, P2331, DOI 10.1096/fj.03-0128fje
   Ido Y, 1997, INVEST OPHTH VIS SCI, V38, P1467
   Issad T, 2010, DIABETES METAB, V36, P423, DOI 10.1016/j.diabet.2010.09.001
   Jackson MJ, 2002, MOL ASPECTS MED, V23, P209, DOI 10.1016/S0098-2997(02)00018-3
   Johnson EL, 2013, ADV EXP MED BIOL, V771, P139
   Jones DP, 2010, DIABETES OBES METAB, V12, P116, DOI 10.1111/j.1463-1326.2010.01266.x
   KADOR PF, 1985, AM J MED, V79, P8, DOI 10.1016/0002-9343(85)90504-2
   Kahn SE, 2014, LANCET, V383, P1068, DOI 10.1016/S0140-6736(13)62154-6
   Karunakaran U, 2013, DIABETES METAB J, V37, P106
   Karunanayake E H, 1974, Biochem J, V142, P673
   Kassab A, 2012, BIOCHIMIE, V94, P1837, DOI 10.1016/j.biochi.2012.01.020
   Katakam PVG, 2012, J CEREBR BLOOD F MET, V32, P792, DOI 10.1038/jcbfm.2011.181
   Katsuki A, 2004, DIABETES CARE, V27, P631, DOI 10.2337/diacare.27.2.631
   Kim JA, 2008, CIRC RES, V102, P401, DOI 10.1161/CIRCRESAHA.107.165472
   Klover PJ, 2004, INT J BIOCHEM CELL B, V36, P753, DOI 10.1016/j.biocel.2003.10.002
   Koga M, 2013, J DIABETES COMPLICAT, V27, P211, DOI 10.1016/j.jdiacomp.2012.12.001
   Lamson Davis W, 2002, Altern Med Rev, V7, P94
   Larion M, 2012, ARCH BIOCHEM BIOPHYS, V519, P103, DOI 10.1016/j.abb.2011.11.007
   Lee AYW, 1999, FASEB J, V13, P23, DOI 10.1096/fasebj.13.1.23
   Leibowitz G, 2010, DIABETES OBES METAB, V12, P66, DOI 10.1111/j.1463-1326.2010.01280.x
   Lemasters JJ, 1997, BIOSCIENCE REP, V17, P281, DOI 10.1023/A:1027332611839
   Lenzen S, 2014, J BIOL CHEM, V289, P12189, DOI 10.1074/jbc.R114.557314
   Li Q, 2008, CARDIOVASC DIABETOL, V7, DOI 10.1186/1475-2840-7-33
   Lima VV, 2012, CLIN SCI, V123, P473, DOI 10.1042/CS20110638
   Lipinski B, 2002, BRIT J NUTR, V87, P93, DOI 10.1079/BJN2001435
   Lovestone S, 2014, P NATL ACAD SCI USA, V111, P4743, DOI 10.1073/pnas.1402277111
   Lugrin J, 2014, BIOL CHEM, V395, P203, DOI 10.1515/hsz-2013-0241
   Ma JF, 2013, EXPERT REV PROTEOMIC, V10, P365, DOI 10.1586/14789450.2013.820536
   Madsen-Bouterse S, 2010, INVEST OPHTH VIS SCI, V51, P1765, DOI 10.1167/iovs.09-4171
   MATSCHINSKY F, 1993, J CLIN INVEST, V92, P2092, DOI 10.1172/JCI116809
   Matschinsky FM, 2002, DIABETES, V51, pS394, DOI 10.2337/diabetes.51.2007.S394
   Matsuoka T, 1997, J CLIN INVEST, V99, P144, DOI 10.1172/JCI119126
   McLarty JL, 2013, LIFE SCI, V92, P621, DOI 10.1016/j.lfs.2012.08.006
   Mellor K. M., 2014, LIFE SCI
   MIRA ML, 1991, BIOCHIM BIOPHYS ACTA, V1060, P257, DOI 10.1016/S0005-2728(05)80315-9
   Mortuza R, 2014, HEART FAIL REV, V19, P75, DOI 10.1007/s10741-013-9381-z
   Muñoz A, 2013, OXID MED CELL LONGEV, V2013, DOI 10.1155/2013/610950
   Murphy MP, 2009, BIOCHEM J, V417, P1, DOI 10.1042/BJ20081386
   Naruse K, 2006, DIABETES, V55, P691, DOI 10.2337/diabetes.55.03.06.db05-0771
   Naviaux RK, 2012, J PHARMACOL EXP THER, V342, P608, DOI 10.1124/jpet.112.192120
   Ng DTF, 1998, DIABETES, V47, P961, DOI 10.2337/diabetes.47.6.961
   Obrosova IG, 2001, PHARMACOLOGY, V62, P172, DOI 10.1159/000056091
   Ohmura C, 2009, ENDOCR J, V56, P149, DOI 10.1507/endocrj.K08E-237
   Oka S, 2012, CIRC RES, V111, P611, DOI 10.1161/CIRCRESAHA.111.247932
   Ola MS, 2006, AM J PHYSIOL-ENDOC M, V290, pE1057, DOI 10.1152/ajpendo.00323.2005
   Otaegui PJ, 2000, HUM GENE THER, V11, P1543, DOI 10.1089/10430340050083270
   Pal M, 2009, DRUG DISCOV TODAY, V14, P784, DOI 10.1016/j.drudis.2009.05.013
   Pall ML, 2007, UNEXPLAINED ILLNESSE
   PAOLISSO G, 1994, METABOLISM, V43, P1426, DOI 10.1016/0026-0495(94)90039-6
   Pennathur S, 2001, J CLIN INVEST, V107, P853, DOI 10.1172/JCI11194
   Piconi L, 2003, CLIN CHEM LAB MED, V41, P1144, DOI 10.1515/CCLM.2003.177
   Poitout V, 2002, ENDOCRINOLOGY, V143, P339, DOI 10.1210/en.143.2.339
   Poitout V, 2008, ENDOCR REV, V29, P351, DOI 10.1210/er.2007-0023
   Postic C, 2001, RECENT PROG HORM RES, V56, P195, DOI 10.1210/rp.56.1.195
   Prentki M, 2006, J CLIN INVEST, V116, P1802, DOI 10.1172/JCI29103
   Pryde KR, 2011, J BIOL CHEM, V286, P18056, DOI 10.1074/jbc.M110.186841
   Pung YF, 2010, WORLD J CARDIOL, V2, P421, DOI 10.4330/wjc.v2.i12.421
   Puthanveetil P, 2012, J MOL CELL CARDIOL, V53, P677, DOI 10.1016/j.yjmcc.2012.08.013
   Queisser MA, 2010, DIABETES, V59, P670, DOI 10.2337/db08-1565
   Rains JL, 2011, FREE RADICAL BIO MED, V50, P567, DOI 10.1016/j.freeradbiomed.2010.12.006
   Rajapakse AG, 2009, OXID MED CELL LONGEV, V2, P172, DOI 10.4161/oxim.2.3.8482
   Rajasekaran NS, 2007, CELL, V130, P427, DOI 10.1016/j.cell.2007.06.044
   Rask-Madsen C, 2013, CELL METAB, V17, P20, DOI 10.1016/j.cmet.2012.11.012
   Rebolledo O R, 2005, Eur Rev Med Pharmacol Sci, V9, P191
   REYES A, 1984, BIOCHEM J, V221, P303, DOI 10.1042/bj2210303
   Rindler PM, 2013, AM J PHYSIOL-HEART C, V305, pH634, DOI 10.1152/ajpheart.00799.2012
   Rivera-Nieves J, 1999, J BIOL CHEM, V274, P19525, DOI 10.1074/jbc.274.28.19525
   Robertson RP, 2005, ANN NY ACAD SCI, V1043, P513, DOI 10.1196/annals.1333.058
   Robertson RP, 2004, J BIOL CHEM, V279, P42351, DOI 10.1074/jbc.R400019200
   ROBERTSON RP, 1992, J CLIN INVEST, V90, P320, DOI 10.1172/JCI115865
   Rosca MG, 2012, DIABETES, V61, P2074, DOI 10.2337/db11-1437
   Roseman Hal M, 2005, J Manag Care Pharm, V11, pS3
   Rösen P, 2001, DIABETES-METAB RES, V17, P189, DOI 10.1002/dmrr.196
   Ruderman NB, 2013, J CLIN INVEST, V123, P2764, DOI 10.1172/JCI67227
   Sakai K, 2003, BIOCHEM BIOPH RES CO, V300, P216, DOI 10.1016/S0006-291X(02)02832-2
   Sasaki S, 2012, DIABETES METAB J, V36, P255, DOI 10.4093/dmj.2012.36.4.255
   Schleicher ED, 2000, KIDNEY INT, V58, pS13, DOI 10.1046/j.1523-1755.2000.07703.x
   Semba RD, 2014, PROTEOM CLIN APPL, V8, P218, DOI 10.1002/prca.201300076
   Sena LA, 2012, MOL CELL, V48, P158, DOI 10.1016/j.molcel.2012.09.025
   Shah S, 2007, ANTIOXID REDOX SIGN, V9, P911, DOI 10.1089/ars.2007.1629
   Siebels I, 2013, BBA-BIOENERGETICS, V1827, P1156, DOI 10.1016/j.bbabio.2013.06.005
   Somesh BP, 2013, BMC CELL BIOL, V14, DOI 10.1186/1471-2121-14-31
   St-Pierre J, 2002, J BIOL CHEM, V277, P44784, DOI 10.1074/jbc.M207217200
   Stadler K, 2013, ADV EXP MED BIOL, V771, P272
   STADTMAN ER, 1988, EXP GERONTOL, V23, P327, DOI 10.1016/0531-5565(88)90036-8
   Stirban A, 2014, MOL METAB, V3, P94, DOI 10.1016/j.molmet.2013.11.006
   Szkudelski T, 2012, EXP BIOL MED, V237, P481, DOI 10.1258/ebm.2012.011372
   Tanaka Y, 1999, P NATL ACAD SCI USA, V96, P10857, DOI 10.1073/pnas.96.19.10857
   Tang WH, 2008, FREE RADICAL BIO MED, V45, P602, DOI 10.1016/j.freeradbiomed.2008.05.003
   Tang WH, 2012, FRONT PHARMACOL, V3, DOI 10.3389/fphar.2012.00087
   Teodoro JS, 2013, TOXICOL MECH METHOD, V23, P297, DOI 10.3109/15376516.2012.759305
   Teshima Y, 2014, CIRC J, V78, P300, DOI 10.1253/circj.CJ-13-1187
   Thornalley PJ, 1999, BIOCHEM J, V344, P109, DOI 10.1042/0264-6021:3440109
   Tiganis T, 2011, TRENDS PHARMACOL SCI, V32, P82, DOI 10.1016/j.tips.2010.11.006
   Tilton RG, 2002, MICROSC RES TECHNIQ, V57, P390, DOI 10.1002/jemt.10092
   TRENTHAM DR, 1968, BIOCHEM J, V109, P603, DOI 10.1042/bj1090603
   Tuch B., 2000, DIABETES RES GUIDE P
   TURRENS JF, 1985, ARCH BIOCHEM BIOPHYS, V237, P408, DOI 10.1016/0003-9861(85)90293-0
   Turrens JF, 1997, BIOSCIENCE REP, V17, P3, DOI 10.1023/A:1027374931887
   Urakawa H, 2003, J CLIN ENDOCR METAB, V88, P4673, DOI 10.1210/jc.2003-030202
   Ussher JR, 2012, CIRC RES, V111, P628, DOI 10.1161/CIRCRESAHA.111.246371
   Valadi H, 2004, CURR GENET, V45, P90, DOI 10.1007/s00294-003-0469-1
   VANDENENDEN MK, 1995, INVEST OPHTH VIS SCI, V36, P1675
   Virág L, 2002, PHARMACOL REV, V54, P375, DOI 10.1124/pr.54.3.375
   Vlassara H, 2013, ENDOCRIN METAB CLIN, V42, P697, DOI 10.1016/j.ecl.2013.07.005
   Wamelink M, 2008, J INHERIT METAB DIS, V31, P703, DOI 10.1007/s10545-008-1015-6
   WELLSKNECHT KJ, 1995, BIOCHEMISTRY-US, V34, P3702, DOI 10.1021/bi00011a027
   WellsKnecht KJ, 1996, NEPHROL DIAL TRANSPL, V11, P41
   Williamson JR, 1998, INVEST OPHTH VIS SCI, V39, P1295
   Williamson JR, 1999, DIABETES RES CLIN PR, V45, P81
   WILLIAMSON JR, 1993, DIABETES, V42, P801, DOI 10.2337/diabetes.42.6.801
   Wittmann I, 1996, DIABETOLOGIA, V39, P1002
   WOLFF SP, 1987, BIOCHEM J, V245, P243, DOI 10.1042/bj2450243
   Xia L, 2007, AM J PHYSIOL-ENDOC M, V293, pE1280, DOI 10.1152/ajpendo.00223.2007
   Xia L, 2008, AM J PHYSIOL-RENAL, V295, pF1705, DOI 10.1152/ajprenal.00043.2008
   Yabe-Nishimura C, 1998, PHARMACOL REV, V50, P21
   Yan LJ, 2007, ELECTROPHORESIS, V28, P1036, DOI 10.1002/elps.200600574
   Yan LJ, 2014, REDOX BIOL, V2, P165, DOI 10.1016/j.redox.2014.01.002
   Yan LJ, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/343154
   Yan LJ, 2013, FREE RADICAL RES, V47, P123, DOI 10.3109/10715762.2012.752078
   Yan Liang-Jun, 2009, Curr Protoc Protein Sci, VChapter 14, DOI 10.1002/0471140864.ps1404s56
   Yan LJ, 2002, EMBO J, V21, P5164, DOI 10.1093/emboj/cdf528
   Yan LJ, 1997, P NATL ACAD SCI USA, V94, P11168, DOI 10.1073/pnas.94.21.11168
   Yang X, 2014, J PHARMACOL SCI, V124, P18, DOI 10.1254/jphs.13151FP
   Yang Y., 2010, OXIDATIVE MED CELLUL, V3
   Yasunari K, 2000, HYPERTENSION, V35, P1092, DOI 10.1161/01.HYP.35.5.1092
   Ye JP, 2013, FRONT MED-PRC, V7, P14, DOI 10.1007/s11684-013-0262-6
   Yeung CM, 2010, J NEUROSCI RES, V88, P2026, DOI 10.1002/jnr.22349
   Yu QJ, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.113.000555
   Zhang T., 2013, North American Journal of Medicine and Science, V6, P87, DOI [10.7156/najms.2013, DOI 10.7156/NAJMS.2013]
NR 191
TC 284
Z9 315
U1 9
U2 51
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PY 2014
VL 2014
AR 137919
DI 10.1155/2014/137919
PG 11
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA AJ9UZ
UT WOS:000338059700001
PM 25019091
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Delibegovic, M
   Zimmer, D
   Kauffman, C
   Rak, K
   Hong, EG
   Cho, YR
   Kim, JK
   Kahn, BB
   Neel, BG
   Bence, KK
AF Delibegovic, Mirela
   Zimmer, Derek
   Kauffman, Caitlin
   Rak, Kimberly
   Hong, Eun-Gyoung
   Cho, You-Ree
   Kim, Jason K.
   Kahn, Barbara B.
   Neel, Benjamin G.
   Bence, Kendra K.
TI Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B)
   Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic
   Reticulum Stress
SO DIABETES
LA English
DT Article
ID INSULIN-RESISTANCE; GLUCOSE-HOMEOSTASIS; GENE-EXPRESSION; HEPATIC
   GLUCONEOGENESIS; FATTY-ACIDS; ER STRESS; IN-VIVO; MICE; RECEPTOR;
   OBESITY
AB OBJECTIVE-The protein tyrosine phosphatase PTP1B is a negative regulator of insulin signaling; consequently, mice deficient in PTP1B are hypersensitive to insulin. Because PTP1B(-/-) mice have diminished fat stores, the extent to which PTP1B directly regulates glucose homeostasis is unclear. Previously, we showed that brain-specific PTP1B(-/-) mice are protected against high-fat diet-induced obesity and glucose intolerance, whereas muscle-specific PTP1B(-/-) mice have increased insulin sensitivity independent of changes in adiposity. Here we studied the role of liver PTP1B in glucose homeostasis and lipid metabolism.
   RESEARCH DESIGN AND METHODS-We analyzed body mass/adiposity, insulin sensitivity, glucose tolerance, and lipid metabolism in liver-specific PTP1B(-/-) and PTP1Bfl/fl control mice, fed a chow or high-fat diet.
   RESULTS-Compared with normal littermates, liver-specific PTP1B(-/-) mice exhibit improved glucose homeostasis and lipid profiles, independent of changes in adiposity. Liver-specific PTP1B(-/-) mice have increased hepatic insulin signaling, decreased expression of gluconeogenic genes PEPCK mid G-6-Pase, enhanced insulin-induced suppression of hepatic glucose production, and improved glucose tolerance. Liver-specific PTP1B(-/-) mice exhibit decreased triglyceride and cholesterol levels and diminished expression of lipogenic genes SREBPs, FAS, and ACC. Liver-specific PTP1B deletion also protects against high-fat diet-induced endoplasmic reticulum stress response in vivo, as evidenced by decreased phosphorylation of p38MAPK, JNK, PERK, and eIF2 alpha and lower expression of the transcription factors C/EBP homologous protein and spliced X box-binding protein 1.
   CONCLUSIONS-Liver PTP1B plays an important role in glucose and lipid metabolism, independent of alterations in adiposity. Inhibition of PTP1B in peripheral tissues may be useful for the treatment of metabolic syndrome and reduction of cardiovascular risk in addition to diabetes. Diabetes 58:590-599, 2009
C1 [Zimmer, Derek; Kauffman, Caitlin; Rak, Kimberly; Bence, Kendra K.] Univ Penn, Sch Vet Med, Dept Anim Biol, Philadelphia, PA 19104 USA.
   [Delibegovic, Mirela; Neel, Benjamin G.] Beth Israel Deaconess Med Ctr, Canc Biol Program, Boston, MA 02215 USA.
   [Delibegovic, Mirela; Kahn, Barbara B.; Neel, Benjamin G.] Harvard Univ, Sch Med, Boston, MA 02115 USA.
   [Hong, Eun-Gyoung; Kim, Jason K.] Penn State Univ, Coll Med, Dept Cellular & Mol Physiol, Hershey, PA USA.
   [Hong, Eun-Gyoung; Cho, You-Ree; Kim, Jason K.] Yale Univ, Sch Med, Dept Internal Med, Sect Endocrinol & Metab, New Haven, CT 06510 USA.
   [Kahn, Barbara B.] Beth Israel Deaconess Med Ctr, Dept Med, Div Endocrinol Diabet & Metab, Boston, MA 02215 USA.
   [Delibegovic, Mirela] Univ Aberdeen, Sch Biol Sci, Aberdeen, Scotland.
   [Neel, Benjamin G.] Ontario Canc Inst, Div Stem Cell & Dev Biol, Toronto, ON M4X 1K9, Canada.
C3 University of Pennsylvania; Harvard University; Harvard University
   Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard
   University; Harvard Medical School; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); Pennsylvania State University; Penn State
   Health; Yale University; Harvard University; Harvard University Medical
   Affiliates; Beth Israel Deaconess Medical Center; University of
   Aberdeen; University of Toronto; University Health Network Toronto
RP Bence, KK (corresponding author), Univ Penn, Sch Vet Med, Dept Anim Biol, Philadelphia, PA 19104 USA.
EM m.delibegovic@abdn.ac.uk; kbence@vet.upenn.edu
OI Delibegovic, Mirela/0000-0001-6193-3152; Bence,
   Kendra/0000-0002-5879-4726; Kim, Jason/0000-0002-7185-042X
FU National Institutes of Health (NIH) [DK 60838, DK 60839, R37 CA49152,
   U24-DK59635]; Physiology Core Grant [DK57521]; American Diabetes
   Association [1-04-RA-47]; Research Councils UK; Diabetes UK project;
   Royal Society; Penn Center for Molecular Studies in Digestive and Liver
   Disease [DK50306]; University of Pennsylvania Research Foundation; USDA;
   Pennsylvania State Department of Health
FX This work was supported by National Institutes of Health (NIH) Grants DK
   60838 (to B.B.K. and B.G.N.), DK 60839 (to B.B.K.), R37 CA49152 (to
   B.G.N.), and U24-DK59635 (to J.K.K.); the Physiology Core Grant DK57521
   (to B.B.K.); and a Research Grant from the American Diabetes Association
   (to B.G.N.). M.D. was the recipient of a postdoctoral fellowship from
   the American Heart Association and is currently supported by Research
   Councils UK Fellowship, Diabetes UK project grant, and the Royal Society
   Research Grant. K.K.B. was supported by a Penn Center for Molecular
   Studies in Digestive and Liver Disease Pilot Grant (DK50306), University
   of Pennsylvania Research Foundation, and the USDA (Section 1433 Animal
   Health and Disease Formula Grant). Lipid analysis was performed at the
   Vanderbilt MMPC Lipid Core (DK59637). Parts of this study were performed
   at the Penn State Mouse Metabolic Phenotyping Center and the Yale Mouse
   Metabolic Phenotyping Center, and the study was supported by grants from
   the American Diabetes Association (1-04-RA-47 to J.K.K.) and the
   Pennsylvania State Department of Health (to J.K.K.).B.G.N. and B.B.K.
   have equity in Ceptyr Inc, a company trying to develop PTP1B inhibitors,
   and B.B.K. also serves on its Scientific Advisory Board. No other
   potential conflicts of interest relevant to this article were
   reported.We thank C. Ronald Kahn (Joslin Diabetes Center) for the
   Alb-Cre mice.
CR Barthel A, 2003, AM J PHYSIOL-ENDOC M, V285, pE685, DOI 10.1152/ajpendo.00253.2003
   Bence KK, 2006, NAT MED, V12, P917, DOI 10.1038/nm1435
   Biddinger SB, 2006, ANNU REV PHYSIOL, V68, P123, DOI 10.1146/annurev.physiol.68.040104.124723
   Biddinger SB, 2008, CELL METAB, V7, P125, DOI 10.1016/j.cmet.2007.11.013
   Brown MS, 2008, CELL METAB, V7, P95, DOI 10.1016/j.cmet.2007.12.009
   Ceddia RB, 2002, FASEB J, V16, DOI 10.1096/fj.02-0158rev
   Cohen SE, 2007, J BIOL CHEM, V282, P23672, DOI 10.1074/jbc.M704053200
   Daitoku H, 2003, DIABETES, V52, P642, DOI 10.2337/diabetes.52.3.642
   DeFronzo RA, 1997, NETH J MED, V50, P191, DOI 10.1016/S0300-2977(97)00012-0
   Delibegovic M, 2007, MOL CELL BIOL, V27, P7727, DOI 10.1128/MCB.00959-07
   Elchebly M, 1999, SCIENCE, V283, P1544, DOI 10.1126/science.283.5407.1544
   FOLCH J, 1957, J BIOL CHEM, V226, P497
   Ginsberg HN, 2006, CELL METAB, V4, P179, DOI 10.1016/j.cmet.2006.08.010
   Goldstein BJ, 2000, J BIOL CHEM, V275, P4283, DOI 10.1074/jbc.275.6.4283
   Gregor MF, 2007, J LIPID RES, V48, P1905, DOI 10.1194/jlr.R700007-JLR200
   Gu F, 2004, J BIOL CHEM, V279, P49689, DOI 10.1074/jbc.C400261200
   Gu F, 2003, MOL CELL BIOL, V23, P3753, DOI 10.1128/MCB.23.11.3753-3762.2003
   Haj FG, 2005, J BIOL CHEM, V280, P15038, DOI 10.1074/jbc.M413240200
   Horton JD, 2002, J CLIN INVEST, V109, P1125, DOI 10.1172/JCI200215593
   Ji C, 2006, J HEPATOL, V45, P321, DOI 10.1016/j.jhep.2006.06.004
   Klaman LD, 2000, MOL CELL BIOL, V20, P5479, DOI 10.1128/MCB.20.15.5479-5489.2000
   Kobayashi K, 2005, CURR DRUG TARGETS, V6, P525, DOI 10.2174/1389450054021972
   Lam TKT, 2005, NAT MED, V11, P320, DOI 10.1038/nm1201
   Lizcano JM, 2002, CURR BIOL, V12, pR236, DOI 10.1016/S0960-9822(02)00777-7
   Marí M, 2006, CELL METAB, V4, P185, DOI 10.1016/j.cmet.2006.07.006
   Michael MD, 2000, MOL CELL, V6, P87, DOI 10.1016/S1097-2765(00)00010-1
   MORRISON WR, 1964, J LIPID RES, V5, P600
   OBrien RM, 1996, PHYSIOL REV, V76, P1109, DOI 10.1152/physrev.1996.76.4.1109
   Özcan U, 2004, SCIENCE, V306, P457, DOI 10.1126/science.1103160
   Pei ZH, 2004, CURR PHARM DESIGN, V10, P3481, DOI 10.2174/1381612043382954
   Puigserver P, 2003, ENDOCR REV, V24, P78, DOI 10.1210/er.2002-0012
   Puigserver P, 2003, NATURE, V423, P550, DOI 10.1038/nature01667
   Ron D, 2007, NAT REV MOL CELL BIO, V8, P519, DOI 10.1038/nrm2199
   Rudel LL, 1998, ARTERIOSCL THROM VAS, V18, P1818, DOI 10.1161/01.ATV.18.11.1818
   Salmeen A, 2000, MOL CELL, V6, P1401, DOI 10.1016/S1097-2765(00)00137-4
   Schröder M, 2005, MUTAT RES-FUND MOL M, V569, P29, DOI 10.1016/j.mrfmmm.2004.06.056
   Shimizu S, 2003, J BIOL CHEM, V278, P43095, DOI 10.1074/jbc.M306880200
   Shimomura I, 1999, J BIOL CHEM, V274, P30028, DOI 10.1074/jbc.274.42.30028
   Shin T, 2000, J Vet Sci, V1, P77
   Shulman GI, 2000, J CLIN INVEST, V106, P171, DOI 10.1172/JCI10583
   Southgate RJ, 2005, FASEB J, V19, P2072, DOI 10.1096/fj.05-3993fje
   Taniguchi CM, 2006, NAT REV MOL CELL BIO, V7, P85, DOI 10.1038/nrm1837
   Taniguchi CM, 2005, J CLIN INVEST, V115, P718, DOI 10.1172/JCI200523187
   Tobe K, 2001, J BIOL CHEM, V276, P38337, DOI 10.1074/jbc.C100160200
   Tollet-Egnell P, 2004, PHYSIOL GENOMICS, V16, P261, DOI 10.1152/physiolgenomics.00093.2002
   Wang JL, 1999, ENDOCRINOLOGY, V140, P2117, DOI 10.1210/en.140.5.2117
   Waring JF, 2003, MOL CELL ENDOCRINOL, V203, P155, DOI 10.1016/S0303-7207(03)00008-X
   Zabolotny JM, 2008, J BIOL CHEM, V283, P14230, DOI 10.1074/jbc.M800061200
   Zabolotny JM, 2004, J BIOL CHEM, V279, P24844, DOI 10.1074/jbc.M310688200
NR 49
TC 230
Z9 264
U1 3
U2 16
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD MAR
PY 2009
VL 58
IS 3
BP 590
EP 599
DI 10.2337/db08-0913
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 414FE
UT WOS:000263848500013
PM 19074988
OA hybrid, Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Bianchi, VE
   Ribisl, PM
AF Bianchi, Vittorio E.
   Ribisl, Paul M.
TI Reactive Oxygen Species Response to Exercise Training and Weight Loss in
   Sedentary Overweight and Obese Female Adults
SO JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
LA English
DT Article
DE community setting intervention; exercise training; oxidative stress;
   reactive oxygen species; weight loss
ID SYSTEMIC OXIDATIVE STRESS; METABOLIC SYNDROME; CAPACITY; TRIAL; MEN
AB PURPOSE: Reactive oxygen species (ROS) are implicated in cardiovascular disease and in the pathogenesis of type 2 diabetes and its complications, and it has been shown to increase insulin resistance. The purpose of this study was to examine the effect of aerobic exercise training and weight loss on ROS in overweight and obese patients as applied in a community clinical setting.
   METHODS: Fifty healthy female clinic patients (M SEM: age, 41.0 1.8 years; body mass index, 28.2 +/- 0.8 kg/m(2)), free of cardiovascular events and not on drug therapy were evaluated before and after 3 months of dietary restriction (similar to 150 to 300 kcal/day deficit) and aerobic training (3 days/week for 1 hour at similar to 75% (V)over dotO(2)max). Measures included ROS, maximal power (kg/min) on cycle ergometry, postexercise heart rate recovery responses at 1 and 2 minutes, and selected anthropometric and hematologic variables.
   RESULTS: Significant (P < .01) improvements were observed after aerobic training and weight loss in body weight in kilograms (-7.1%); maximal power in kg/min (+32.6%), ROS in U.CARR (Carratelli units) (-25.7%); and heart rate recovery 1 minute in beats per minute (-37.6%) following the program. Significant improvements were also noted in other anthropometric, cardiovascular, and hematologic measures.
   CONCLUSIONS: A 12-week program of nutritional and exercise intervention in overweight/obese sedentary women improves levels of oxidative stress when accompanied by weight loss and improved fitness. More than restricted caloric intake, physical activity at a relatively high intensity was effective in improving cardiovascular risk markers. The reduction in ROS may be an additional mechanism by which physical activity may contribute to preventing metabolic syndrome and subsequent atherosclerotic disease.
C1 [Bianchi, Vittorio E.] Ctr Clin Nutr Metab & Phys Performance, San Marino, Italy.
   [Ribisl, Paul M.] Wake Forest Univ, Dept Hlth & Exercise Sci, Winston Salem, NC 27109 USA.
C3 Wake Forest University
RP Ribisl, PM (corresponding author), Wake Forest Univ, Dept Hlth & Exercise Sci, 303 Gymnasium, Winston Salem, NC 27109 USA.
EM pmribisl@gmail.com
RI bianchi, vittorio/I-1396-2013
OI Bianchi, Vittorio/0000-0003-3689-9970
CR Arsenault BJ, 2009, ATHEROSCLEROSIS, V207, P530, DOI 10.1016/j.atherosclerosis.2009.05.009
   Beekley MD, 2004, RES Q EXERCISE SPORT, V75, P337, DOI 10.1080/02701367.2004.10609165
   Cesarone MR, 1999, INT ANGIOL, V18, P127
   Edwards DG, 2004, AM J CARDIOL, V93, P617, DOI 10.1016/j.amjcard.2003.11.032
   Esposito K, 2003, JAMA-J AM MED ASSOC, V289, P1799, DOI 10.1001/jama.289.14.1799
   Fischer CP, 2006, EXERC IMMUNOL REV, V12, P6
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Galassetti PR, 2006, J INVEST MED, V54, P67, DOI 10.2310/6650.2005.05024
   Iijima K, 2012, GERIATR GERONTOL INT, V12, P68, DOI 10.1111/j.1447-0594.2011.00814.x
   Kaneto H, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/453892
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Milagro FI, 2006, OBESITY, V14, P1118, DOI 10.1038/oby.2006.128
   Myers J, 2002, NEW ENGL J MED, V346, P793, DOI 10.1056/NEJMoa011858
   Savage PD, 2011, J CARDIOPULM REHABIL, V31, P333, DOI 10.1097/HCR.0b013e31822f0f79
   Yokota T, 2013, DIABETES CARE, V36, P1341, DOI 10.2337/dc12-1161
NR 15
TC 10
Z9 12
U1 0
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1932-7501
EI 1932-751X
J9 J CARDIOPULM REHABIL
JI J. Cardiopulm. Rehabil. Prev.
PD JUL-AUG
PY 2015
VL 35
IS 4
BP 263
EP 267
DI 10.1097/HCR.0000000000000114
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CM8IK
UT WOS:000357942700006
PM 25806958
DA 2025-06-11
ER

PT J
AU Hagiwara, S
   Gohda, T
   Tanimoto, M
   Ito, T
   Murakoshi, M
   Ohara, I
   Yamazaki, T
   Matsumoto, M
   Horikoshi, S
   Funabiki, K
   Tomino, Y
AF Hagiwara, Shinji
   Gohda, Tomohito
   Tanimoto, Mitsuo
   Ito, Takamichi
   Murakoshi, Maki
   Ohara, Ikko
   Yamazaki, Takahiko
   Matsumoto, Masakazu
   Horikoshi, Satoshi
   Funabiki, Kazuhiko
   Tomino, Yasuhiko
TI Effects of pyridoxamine (K-163) on glucose intolerance and obesity in
   high-fat diet C57BL/6J mice
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID TYPE-2 DIABETIC-NEPHROPATHY; INDUCED INSULIN-RESISTANCE; ACTIVATED
   SIGNALING PATHWAYS; INCREASED OXIDATIVE STRESS; GLYCATION END-PRODUCTS;
   BETA-CELL DYSFUNCTION; ALPHA-LIPOIC ACID; METABOLIC SYNDROME; 3T3-L1
   ADIPOCYTES; GLUT4 TRANSLOCATION
AB Advanced glycation end products (AGEs) contribute to the pathogenesis of diabetes-associated complications. Previously, we reported the possible effect of pyridoxamine (K-163), an AGE inhibitor, on improvement of glucose intolerance in type 2 diabetes mellitus KK-A(y)/Ta mice. Recently, AGEs and oxidative stress have been shown to induce insulin resistance. The objective of the present study is to examine the effect of pyridoxamine on glucose intolerance and oxidative stress. C57BL/6J mice were divided into 3 groups as follows: low-fat diet, high-fat diet, and high-fat diet with pyridoxamine treatment. Body and adipose tissue weight, serum insulin, hydrogen peroxide, malondialdehyde and AGE, and urinary 8-hydroxy-2'-deoxyguanosine levels were measured. Nicotinamide adenine dinucleotide phosphate subunits, antioxidant enzymes, and adipocytokine messenger RNA expressions in the adipose tissues were evaluated. Akt/protein kinase B activity and glucose transporter 4 translocation in skeletal muscle were also evaluated. Body and adipose tissue weights of the pyridoxamine treatment group were significantly decreased compared with those of the high-fat diet group. Pyridoxamine attenuated serum hydrogen peroxide, malondialdehyde and AGE, and urinary 8-hydroxy-2'-deoxyguanosine and nicotinamide adenine dinucleotide phosphate oxidase expression-, increased antioxidant enzyme expression; and improved dysregulation of adipocytokines in adipose tissues. Pyridoxamine improved blood glucose levels after glucose injection and fasting hyperinsulinemia. Suppressed Akt/protein kinase B activity and glucose transporter 4 translocation in skeletal muscle in high-fat diet mice were improved by pyridoxamine treatment. It appears that the antioxidative effect of pyridoxamine is associated with improvement of glucose intolerance and obesity in C57BL/6J mice fed a high-fat diet. We assume that pyridoxamine may be useful in the treatment of the obesity-associated metabolic syndrome. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Hagiwara, Shinji; Gohda, Tomohito; Tanimoto, Mitsuo; Ito, Takamichi; Murakoshi, Maki; Ohara, Ikko; Yamazaki, Takahiko; Matsumoto, Masakazu; Horikoshi, Satoshi; Tomino, Yasuhiko] Juntendo Univ, Sch Med, Dept Internal Med, Div Nephrol, Tokyo 1138421, Japan.
   [Funabiki, Kazuhiko] Juntendo Tokyo Koto Geriatr Med Ctr, Dept Hypertens & Nephrol, Tokyo 1360075, Japan.
   [Hagiwara, Shinji] Juntendo Univ, Grad Sch Med, Sportol Ctr, Tokyo 1138421, Japan.
C3 Juntendo University; Juntendo University; Juntendo University
RP Tomino, Y (corresponding author), Juntendo Univ, Sch Med, Dept Internal Med, Div Nephrol, Tokyo 1138421, Japan.
EM yasu@juntendo.ac.jp
RI GOHDA, TOMOHITO/Y-6867-2019
FU Ministry of Education, Culture, Sports, Science, and Technology of Japan
FX We thank Kowa (Tokyo, Japan) for providing K-163. We also thank Ms
   Terumi Shibata, Dr Mariko Tamano, Mr Yoshihiro Kubota, and Ms Mayumi
   Ishiwata. for their skillful technical support and advice. This study
   was partly supported by High Technology Research Center Grant from the
   Ministry of Education, Culture, Sports, Science, and Technology of
   Japan.
CR BROWNLEE M, 1995, ANNU REV MED, V46, P223, DOI 10.1146/annurev.med.46.1.223
   Bruce CR, 2003, DIABETES, V52, P2338, DOI 10.2337/diabetes.52.9.2338
   Carmen GY, 2006, CELL SIGNAL, V18, P401, DOI 10.1016/j.cellsig.2005.08.009
   Ceriello A, 2000, METABOLISM, V49, P27, DOI 10.1016/S0026-0495(00)80082-7
   Degenhardt TP, 2002, KIDNEY INT, V61, P939, DOI 10.1046/j.1523-1755.2002.00207.x
   Dröge W, 2002, PHYSIOL REV, V82, P47, DOI 10.1152/physrev.00018.2001
   Erol A, 2007, BIOESSAYS, V29, P811, DOI 10.1002/bies.20618
   Evans J L., 2003, Diabetes: From research to diagnosis and treatment, P479
   Evans JL, 2003, DIABETES, V52, P1, DOI 10.2337/diabetes.52.1.1
   Evans JL, 2002, ENDOCR REV, V23, P599, DOI 10.1210/er.2001-0039
   Ford ES, 2003, DIABETES, V52, P2346, DOI 10.2337/diabetes.52.9.2346
   Fruebis J, 2001, P NATL ACAD SCI USA, V98, P2005, DOI 10.1073/pnas.041591798
   Furukawa S, 2004, J CLIN INVEST, V114, P1752, DOI 10.1172/JCI20042162S
   Gronning LM, 2002, MOL ENDOCRINOL, V16, P873, DOI 10.1210/me.16.4.873
   Hitsumoto Takashi, 2003, J Cardiol, V42, P119
   Ito T, 2006, NEPHROLOGY, V11, P29, DOI 10.1111/j.1440-1797.2006.00543.x
   Jacob S, 1999, FREE RADICAL BIO MED, V27, P309, DOI 10.1016/S0891-5849(99)00089-1
   Jortner BS, 2000, TOXICOL PATHOL, V28, P54, DOI 10.1177/019262330002800108
   Kuniyasu A, 2003, FEBS LETT, V537, P85, DOI 10.1016/S0014-5793(03)00096-6
   Levine S, 2004, J APPL TOXICOL, V24, P497, DOI 10.1002/jat.1007
   Maddux BA, 2001, DIABETES, V50, P404, DOI 10.2337/diabetes.50.2.404
   Matsuzawa Y, 2004, ARTERIOSCL THROM VAS, V24, P29, DOI 10.1161/01.ATV.0000099786.99623.EF
   McCormick DB, 1999, J NUTR, V129, P325
   Miele C, 2003, J BIOL CHEM, V278, P47376, DOI 10.1074/jbc.M301088200
   Ogihara T, 2002, HYPERTENSION, V40, P872, DOI 10.1161/01.HYP.0000040262.48405.A8
   Okamoto Y, 2002, CIRCULATION, V106, P2767, DOI 10.1161/01.CIR.0000042707.50032.19
   Onorato JM, 2000, J BIOL CHEM, V275, P21177, DOI 10.1074/jbc.M003263200
   Rösen P, 2001, DIABETES-METAB RES, V17, P189, DOI 10.1002/dmrr.196
   Rudich A, 1998, DIABETES, V47, P1562, DOI 10.2337/diabetes.47.10.1562
   SHIMOMURA F, 1996, NAT MED, P800
   *SIGM ALDR CHEM CO, P9380 SIGM ALDR CHEM
   Smith SR, 2003, DIABETES, V52, P1611, DOI 10.2337/diabetes.52.7.1611
   Takatori A, 2004, DIABETES-METAB RES, V20, P211, DOI 10.1002/dmrr.428
   Tanimoto M, 2007, METABOLISM, V56, P160, DOI 10.1016/j.metabol.2006.08.026
   Tirosh A, 1999, J BIOL CHEM, V274, P10595, DOI 10.1074/jbc.274.15.10595
   Ukeda H, 1999, BIOSCI BIOTECH BIOCH, V63, P485, DOI 10.1271/bbb.63.485
   Unger RH, 2003, ANNU REV PHYSIOL, V65, P333, DOI 10.1146/annurev.physiol.65.092101.142622
   Urakawa H, 2003, J CLIN ENDOCR METAB, V88, P4673, DOI 10.1210/jc.2003-030202
   Uysal KT, 1997, NATURE, V389, P610, DOI 10.1038/39335
   Vlassara H, 2002, J INTERN MED, V251, P87, DOI 10.1046/j.1365-2796.2002.00932.x
   Voziyan PA, 2005, CELL MOL LIFE SCI, V62, P1671, DOI 10.1007/s00018-005-5082-7
   West IC, 2000, DIABETIC MED, V17, P171, DOI 10.1046/j.1464-5491.2000.00259.x
   Yamauchi T, 2003, J BIOL CHEM, V278, P2461, DOI 10.1074/jbc.M209033200
   Yamauchi T, 2001, NAT MED, V7, P941, DOI 10.1038/90984
   Yasukawa T, 2005, J BIOL CHEM, V280, P7511, DOI 10.1074/jbc.M411871200
   Zalba G, 2001, HYPERTENSION, V38, P1395, DOI 10.1161/hy1201.099611
   Zhang MF, 2006, METABOLISM, V55, P1590, DOI 10.1016/j.metabol.2006.07.019
NR 47
TC 28
Z9 36
U1 0
U2 10
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUL
PY 2009
VL 58
IS 7
BP 934
EP 945
DI 10.1016/j.metabol.2009.02.033
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 460LZ
UT WOS:000267190500006
PM 19427656
DA 2025-06-11
ER

PT J
AU Perras, B
   Berkemeier, E
   Rasch, B
   Fehm, HL
   Born, J
AF Perras, B.
   Berkemeier, E.
   Rasch, B.
   Fehm, H. L.
   Born, J.
TI PreproTRH(158-183) fails to affect pituitary-adrenal response
   to CRH/vasopressin in man:: A pilot study
SO NEUROPEPTIDES
LA English
DT Article
DE cortisol; ACTH; PreproTRH((158-183)); PreproTRH((178-199)); human
ID RELEASE-INHIBITING FACTOR; ADRENOCORTICAL AXIS; SLEEP; SECRETION;
   HORMONE; STRESS; HUMANS; NEUROENDOCRINE; HYPOTHALAMUS; WAKEFULNESS
AB Non-glucocorticoid inhibitors of the HPA-system are of utmost interest in the treatment of diseases with impaired regulation of this system, like the metabolic syndrome and depression. In rats, a fragment of the thyreotropin-releasing hormone (TRH) preprohormone, preproTRH((178-199)), has been demonstrated to inhibit basal and stimulated secretion of cortisol. Our pilot study aimed to explore the first time similar effects of the homologue peptide preproTRH((158-193)) in healthy humans. In a double-blind within-subject comparison, eight healthy young men were infused intravenously with placebo and preproTRH((158-183)) at varying doses of 5, 10, 25 and 50 mg/kg of body weight. After 15 min of infusion a corticotropin-releasing hormone (CRH)/vasopressin-test was performed. Plasma concentrations of pituitary hormones and free thyroxine, blood pressure, heart rate and feelings of activation and mood were assessed repeatedly at close intervals. Individual hormone profiles and collapsed data across all doses did not reveal any effects of preproTRH((158-183)) on HPA-activity, although it increased TSH and fT4, stimulated the release of GH and increased systolic blood pressure in the course of the experiment (p < 0.05, for all effects). Self-reports indicated enhanced feelings of activation and general well-being following preproTRH (p < 0.05). Our data exclude a substantial inhibitory effect of preproTRH((158-183)) on HPA secretory activity and, thus, contrast with findings in rats. In humans, the peptide appears to even exert an albeit weak stimulatory effect on autonomic stress systems as indicated by increased cardiovascular activity in combination with enhanced subjective arousal. (C) 2007 Elsevier Ltd. All rights reserved.
C1 Med Univ Lubeck, Dept Internal Med 1, D-23538 Lubeck, Germany.
   Med Univ Lubeck, Dept Neuroendocrinol, D-23538 Lubeck, Germany.
C3 University of Lubeck; University of Lubeck
RP Perras, B (corresponding author), Med Univ Lubeck, Dept Internal Med 1, D-23538 Lubeck, Germany.
EM Perras@kfg.mu-luebeck.de
RI Born, Jan/K-2596-2016; Rasch, Bjorn/A-3119-2015
OI Born, Jan/0000-0002-1847-6248; Rasch, Bjorn/0000-0001-7607-3415
CR Bierwolf C, 1997, J NEUROENDOCRINOL, V9, P479, DOI 10.1046/j.1365-2826.1997.00605.x
   Born J, 1998, EXP CLIN ENDOCR DIAB, V106, P153, DOI 10.1055/s-0029-1211969
   Buckley TM, 2005, J CLIN ENDOCR METAB, V90, P3106, DOI 10.1210/jc.2004-1056
   Chrousos GP, 2000, INT J OBESITY, V24, pS50, DOI 10.1038/sj.ijo.0801278
   Engler D, 1999, ENDOCR REV, V20, P460, DOI 10.1210/er.20.4.460
   ENGLER D, 1988, NEUROENDOCRINOLOGY, V48, P551, DOI 10.1159/000125062
   Jacobson L, 2005, ENDOCRIN METAB CLIN, V34, P271, DOI 10.1016/j.ecl.2005.01.003
   Janke W., 1978, Die Eigenschaftsworterliste: EWL; eine mehrdimensionale Methode zur Beschreibung von Aspekten des Befindens
   McEwen BS, 2005, METABOLISM, V54, P20, DOI 10.1016/j.metabol.2005.01.008
   McGivern RF, 1997, J NEUROSCI, V17, P4886
   MERCER JE, 1989, NEUROENDOCRINOLOGY, V50, P280, DOI 10.1159/000125234
   MORI M, 1992, J CLIN ENDOCR METAB, V75, P1535, DOI 10.1210/jc.75.6.1535
   PIETROWSKY R, 1992, Z EXP ANGEW PSYCHOL, V39, P278
   Plihal W, 1996, PSYCHONEUROENDOCRINO, V21, P515, DOI 10.1016/S0306-4530(96)00011-X
   Raza J, 1998, CLIN ENDOCRINOL, V48, P217, DOI 10.1046/j.1365-2265.1998.00382.x
   Redei E, 1998, ANN NY ACAD SCI, V840, P456, DOI 10.1111/j.1749-6632.1998.tb09584.x
   REDEI E, 1995, ENDOCRINOLOGY, V136, P3557, DOI 10.1210/en.136.8.3557
   REDEI E, 1995, ENDOCRINOLOGY, V136, P1813, DOI 10.1210/en.136.4.1813
   SPATHSCHWALBE E, 1993, J CLIN ENDOCR METAB, V77, P1170, DOI 10.1210/jc.77.5.1170
   SPATHSCHWALBE E, 1994, NEUROENDOCRINOLOGY, V60, P544, DOI 10.1159/000126793
   Swaab DF, 2005, AGEING RES REV, V4, P141, DOI 10.1016/j.arr.2005.03.003
NR 21
TC 1
Z9 1
U1 0
U2 1
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0143-4179
J9 NEUROPEPTIDES
JI Neuropeptides
PD AUG
PY 2007
VL 41
IS 4
BP 233
EP 238
DI 10.1016/j.npep.2007.03.002
PG 6
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 197WA
UT WOS:000248586000005
PM 17482675
DA 2025-06-11
ER

PT J
AU Xu, D
   Xia, LP
   Zhang, BJ
   Shen, L
   Lei, YY
   Liu, L
   Zhang, L
   Magdalou, J
   Wang, H
AF Xu, Dan
   Xia, Li-ping
   Zhang, Ben-jian
   Shen, Lang
   Lei, You-ying
   Liu, Lian
   Zhang, Li
   Magdalou, Jacques
   Wang, Hui
TI Prenatal nicotine exposure enhances the susceptibility to metabolic
   syndrome in adult offspring rats fed high-fat diet via alteration of HPA
   axis-associated neuroendocrine metabolic programming
SO ACTA PHARMACOLOGICA SINICA
LA English
DT Article
DE nicotine; intrauterine growth retardation;
   hypothalamic-pituitary-adrenal axis; neuroendocrine metabolic
   programming; high-fat diet; stress; metabolic syndrome; insulin;
   glucose; lipid; gender difference
ID PITUITARY-ADRENAL AXIS; INSULIN-RESISTANCE; MATERNAL SMOKING;
   GENE-EXPRESSION; INDUCED OBESITY; BLOOD-PRESSURE; FETAL ORIGINS; GROWTH;
   STRESS; PREGNANCY
AB Aim: Prenatal nicotine exposure (PNE) alters the hypothalamic-pituitary-adrenocortical (HPA) axis-associated neuroendocrine metabolic programming in intrauterine growth retardation offspring rats. In this study we aimed to clarify the susceptibility to metabolic diseases of PNE offspring rats fed a high-fat diet.
   Methods: Maternal Wistar rats were injected with nicotine (1.0 mg/kg, sc) twice per day from gestational day 11 until full-term delivery, and all pups were fed a high-fat diet after weaning and exposed to unpredictable chronic stress (UCS) during postnatal weeks 18-20. Blood samples were collected before and after chronic stress, and serum ACTH, corticosterone, glucose, insulin, total cholesterol, triglyceride and free fatty acids levels were measured. The hypothalamus, pituitary gland and liver were dissected for histological studies.
   Results: UCS significantly increased the serum ACTH, corticosterone and insulin levels as well as the insulin resistant index without changing the serum glucose, total cholesterol, triglyceride and free fatty acids levels in adult offspring rats without PNE. The body weight of PNE offspring rats presented a typical "catch-up" growth pattern. PNE not only aggravated the UCS-induced changes in the HPA axis programmed alteration (caused further increases in the serum ACTH and corticosterone levels), but also significantly changed the glucose and lipid metabolism after UCS (caused further increases in the serum glucose level and insulin resistant index, and decrease in the serum free fatty acids). The effects of PNE on the above indexes after UCS showed gender differences. Pathological studies revealed that PNE led to plenty of lipid droplets in multiple organs.
   Conclusion: PNE enhances not only the HPA axis, but also the susceptibility to metabolic diseases in adult offspring rats fed a high-fat diet after UCS in a gender-specific manner and enhances the susceptibility to metabolic diseases in adult offspring rats fed a high-fat diet.
C1 [Xu, Dan; Xia, Li-ping; Zhang, Ben-jian; Shen, Lang; Lei, You-ying; Liu, Lian; Zhang, Li; Wang, Hui] Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China.
   [Xu, Dan; Wang, Hui] Wuhan Univ, Res Ctr Food & Drug Evaluat, Wuhan 430071, Peoples R China.
   [Magdalou, Jacques] Nancy Univ, Fac Med, CNRS, UMR 7561, Vandoeuvre Les Nancy, France.
C3 Wuhan University; Wuhan University; Universite de Lorraine; Centre
   National de la Recherche Scientifique (CNRS)
RP Wang, H (corresponding author), Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China.
EM wanghui19@whu.edu.cn
RI Zhang, Benjian/ABC-1130-2020
FU National Natural Science Foundation of China [30830112, 81072709,
   81220108026, 81371483]; Chinese Ministry of Education [V200801]
FX This work was supported by grants from the National Natural Science
   Foundation of China (No 30830112, 81072709, 81220108026, and 81371483)
   and the Key Grant Project of the Chinese Ministry of Education (No
   V200801).
CR Aguila MB, 2003, NUTRITION, V19, P347, DOI 10.1016/S0899-9007(02)00934-6
   Alisi A, 2011, INT J ENDOCRINOL, V2011, DOI 10.1155/2011/269853
   Amengual-Cladera E, 2012, METABOLISM, V61, P1108, DOI 10.1016/j.metabol.2011.12.016
   Boersma B, 1997, ENDOCR REV, V18, P646, DOI 10.1210/er.18.5.646
   Bol VV, 2009, AM J PHYSIOL-REG I, V297, pR291, DOI 10.1152/ajpregu.90497.2008
   Briana DD, 2009, EUR J ENDOCRINOL, V160, P337, DOI 10.1530/EJE-08-0621
   Buettner R, 2006, J MOL ENDOCRINOL, V36, P485, DOI 10.1677/jme.1.01909
   Caluwaerts S, 2007, METABOLISM, V56, P1431, DOI 10.1016/j.metabol.2007.06.007
   Chan O, 2003, Minerva Endocrinol, V28, P87
   Czekaj P, 2002, INT ARCH OCC ENV HEA, V75, pS27, DOI 10.1007/s00420-002-0343-3
   Dong-Feng GU, 2005, CHINESE J DIABETES, V13, P181
   Ford ES, 2010, J DIABETES, V2, P180, DOI 10.1111/j.1753-0407.2010.00078.x
   Fowden AL, 2008, J NEUROENDOCRINOL, V20, P439, DOI 10.1111/j.1365-2826.2008.01663.x
   Fowden AL, 2005, EARLY HUM DEV, V81, P723, DOI 10.1016/j.earlhumdev.2005.06.007
   Fraulob JC, 2010, J CLIN BIOCHEM NUTR, V46, P212, DOI 10.3164/jcbn.09-83
   Da Silveira VMF, 2008, REV SAUDE PUBL, V42, P10, DOI 10.1590/S0034-89102008000100002
   Fu JH, 2009, EXP CLIN ENDOCR DIAB, V117, P354, DOI 10.1055/s-0028-1119406
   HALES CN, 1992, DIABETOLOGIA, V35, P595, DOI 10.1093/ije/dyt133
   Isganaitis E, 2009, DIABETES, V58, P1192, DOI 10.2337/db08-1266
   Kanaka-Gantenbein C, 2010, ANN NY ACAD SCI, V1205, P99, DOI 10.1111/j.1749-6632.2010.05683.x
   Kinzler WL, 2007, SEMIN PERINATOL, V31, P126, DOI 10.1053/j.semperi.2007.03.004
   Kobayasi R, 2010, J HYPERTENS, V28, P2111, DOI 10.1097/HJH.0b013e32833ca68c
   Langdon KD, 2011, NEUROSCIENCE, V182, P82, DOI 10.1016/j.neuroscience.2011.03.028
   Langley-Evans SC, 2009, J ANAT, V215, P36, DOI 10.1111/j.1469-7580.2008.00977.x
   Liu L, 2012, TOXICOL LETT, V214, P307, DOI 10.1016/j.toxlet.2012.09.001
   Manuel-Apolinar L, 2010, ARCH MED RES, V41, P240, DOI 10.1016/j.arcmed.2010.06.002
   Nelson E, 1999, HUM EXP TOXICOL, V18, P257, DOI 10.1191/096032799678840011
   Ojeda NB, 2007, HYPERTENSION, V50, P679, DOI 10.1161/HYPERTENSIONAHA.107.091785
   Ojeda NB, 2007, AM J PHYSIOL-REG I, V292, pR758, DOI 10.1152/ajpregu.00311.2006
   Panchal SK, 2011, J BIOMED BIOTECHNOL, DOI 10.1155/2011/351982
   Pinheiro CR, 2011, HORM METAB RES, V43, P693, DOI 10.1055/s-0031-1285909
   QUIGLEY ME, 1979, AM J OBSTET GYNECOL, V133, P685, DOI 10.1016/0002-9378(79)90019-X
   Ravelli ACJ, 1999, AM J CLIN NUTR, V70, P811
   Reynolds RM, 2010, J STEROID BIOCHEM, V122, P3, DOI 10.1016/j.jsbmb.2010.01.009
   Romo Agustin, 2009, Pediatr Endocrinol Rev, V6 Suppl 3, P332
   Shin AC, 2010, INT J OBESITY, V34, P1218, DOI 10.1038/ijo.2010.34
   Slotkin TA, 1998, J PHARMACOL EXP THER, V285, P931
   Suzuki K, 2008, J EPIDEMIOL, V18, P89, DOI 10.2188/jea.JE2007415
   Tannenbaum BM, 1997, AM J PHYSIOL-ENDOC M, V273, pE1168, DOI 10.1152/ajpendo.1997.273.6.E1168
   Touati S, 2011, MED SCI SPORT EXER, V43, P398, DOI 10.1249/MSS.0b013e3181eeb12d
   Tsigos C, 2002, J PSYCHOSOM RES, V53, P865, DOI 10.1016/S0022-3999(02)00429-4
   Vieau D, 2007, PSYCHONEUROENDOCRINO, V32, pS16, DOI 10.1016/j.psyneuen.2007.03.014
   Wang H, 2006, PHARMACOL RES, V53, P28, DOI 10.1016/j.phrs.2005.08.005
   Wang YH, 2010, OBESITY, V18, P588, DOI 10.1038/oby.2009.296
   Willner P, 2005, NEUROPSYCHOBIOLOGY, V52, P90, DOI 10.1159/000087097
   Woods SC, 2003, J NUTR, V133, P1081, DOI 10.1093/jn/133.4.1081
   Xita N, 2010, ANN NY ACAD SCI, V1205, P148, DOI 10.1111/j.1749-6632.2010.05658.x
   Xu D, 2012, TOXICOL LETT, V209, P282, DOI 10.1016/j.toxlet.2012.01.006
   Yajnik CS, 2009, INT J GYNECOL OBSTET, V104, pS27, DOI 10.1016/j.ijgo.2008.11.034
   Yildiz D, 2004, TOXICON, V43, P619, DOI 10.1016/j.toxicon.2004.01.017
   Zhuang YL, 2003, MODERN OBSTET, P384
NR 51
TC 34
Z9 39
U1 2
U2 19
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1671-4083
EI 1745-7254
J9 ACTA PHARMACOL SIN
JI Acta Pharmacol. Sin.
PD DEC
PY 2013
VL 34
IS 12
BP 1526
EP 1534
DI 10.1038/aps.2013.171
PG 9
WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA 269UV
UT WOS:000328268600006
PM 24270239
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Van Hoorenbeeck, K
   Franckx, H
   Debode, P
   Aerts, P
   Wouters, K
   Ramet, J
   Van Gaal, LF
   Desager, KN
   De Backer, WA
   Verhulst, SL
AF Van Hoorenbeeck, Kim
   Franckx, Hilde
   Debode, Patrick
   Aerts, Petra
   Wouters, Kristien
   Ramet, Jose
   Van Gaal, Luc F.
   Desager, Kristine N.
   De Backer, Wilfried A.
   Verhulst, Stijn L.
TI Weight Loss and Sleep-Disordered Breathing in Childhood Obesity: Effects
   on Inflammation and Uric Acid
SO OBESITY
LA English
DT Article
ID SYSTEMIC INFLAMMATION; METABOLIC SYNDROME; CHILDREN; ADOLESCENTS;
   OVERWEIGHT; APNEA; ADENOTONSILLECTOMY; PREVALENCE
AB Sleep-disordered breathing (SDB) is prevalent in childhood obesity. It may be an independent risk factor for the metabolic syndrome. Possible mechanisms are inflammation and oxidative stress. Adenotonsillectomy in childhood obesity is associated with a high recurrence rate and risk of postoperative weight gain. Therefore, this study assessed the effects of SDB on inflammation and oxidative stress in childhood obesity before and after weight loss. We included 132 obese subjects between 10 and 18 years consecutively. Median age was 15.4 years (10.1-18.0). Mean BMI z-score was 2.72 +/- 0.42. Leukocytes and differentiation, high sensitivity C-reactive protein (hs-CRP), and uric acid (UA) were determined at baseline and subjects underwent a sleep assessment. SDB was diagnosed in 39%. Linear regression analysis showed an association between UA(log) and oxygen desaturation index(log) (ODI(log)) (r = 0.20; P = 0.03), between leukocytes log and respiratory disturbance index(log) (RDI(log)) (r = 0.23; P = 0.01), and between lymphocytes(log) and RDI(log) (r = 0.19; P = 0.04). Follow-up was organized after 4-6 months of treatment. Median decrease in BMI z-score was 32%. Laboratory measurements were repeated. Subjects with SDB at baseline underwent a second sleep study. Of these 49 subjects, 12 showed residual SDB. This corresponds with a treatment success rate of 71%. Unlike changes in inflammatory markers, improvements in UA were associated with improvements in RDI and ODI (respectively: r = 0.44; P = 0.007, r = 0.41; P = 0.01). In conclusion, weight loss is effective in treating obese children with SDB. At baseline, a link exists between inflammation and SDB. Oxidative stress is reflected by UA at baseline and the concentration decreases after treatment according to improvements in SDB.
C1 [Van Hoorenbeeck, Kim; Aerts, Petra; Ramet, Jose; Van Gaal, Luc F.; De Backer, Wilfried A.] Univ Antwerp, Lab Expt Med & Pediat, B-2020 Antwerp, Belgium.
   [Franckx, Hilde; Debode, Patrick] Zeepreventorium, De Haan, Belgium.
   [Wouters, Kristien] Univ Antwerp Hosp, Dept Stat, Edegem, Belgium.
   [Ramet, Jose; Desager, Kristine N.; Verhulst, Stijn L.] Univ Antwerp Hosp, Dept Pediat, Edegem, Belgium.
   [Van Gaal, Luc F.] Univ Antwerp Hosp, Dept Endocrinol Diabetol & Metab, Edegem, Belgium.
   [De Backer, Wilfried A.] Univ Antwerp Hosp, Dept Pulmonol, Edegem, Belgium.
C3 University of Antwerp; University of Antwerp; University of Antwerp;
   University of Antwerp; University of Antwerp
RP Van Hoorenbeeck, K (corresponding author), Univ Antwerp, Lab Expt Med & Pediat, B-2020 Antwerp, Belgium.
EM kim.vanhoorenbeeck@ua.ac.be
RI Van Hoorenbeeck, Kim/GLS-2363-2022; Wouters, Kristien/ADM-4146-2022;
   Verhulst, Stijn/B-1702-2008
OI Van Hoorenbeeck, Kim/0000-0002-8812-4440; Verhulst,
   Stijn/0000-0002-1922-9716; Wouters, Kristien/0000-0001-9263-186X
CR Amin R, 2008, AM J RESP CRIT CARE, V177, P654, DOI 10.1164/rccm.200710-1610OC
   Bhattacharjee R, 2010, AM J RESP CRIT CARE, V182, P676, DOI 10.1164/rccm.200912-1930OC
   Chai-Coetzer CL, 2011, THORAX, V66, P213, DOI 10.1136/thx.2010.152801
   Costa DJ, 2009, OTOLARYNG HEAD NECK, V140, P455, DOI 10.1016/j.otohns.2008.12.038
   Erman MK, 2007, J CLIN SLEEP MED, V3, P387
   Gozal D, 2008, SLEEP MED, V9, P254, DOI 10.1016/j.sleep.2007.04.013
   Kalra M, 2005, OBES RES, V13, P1175, DOI 10.1038/oby.2005.139
   Kheirandish-Gozal L, 2006, J CLIN SLEEP MED, V2, P301
   Marcus CL, 2001, AM J RESP CRIT CARE, V164, P16, DOI 10.1164/ajrccm.164.1.2008171
   Ng SSS, 2009, INTERN MED J, V39, P757, DOI 10.1111/j.1445-5994.2008.01827.x
   Redline S, 1999, AM J RESP CRIT CARE, V159, P1527, DOI 10.1164/ajrccm.159.5.9809079
   Redline S, 2007, AM J RESP CRIT CARE, V176, P401, DOI 10.1164/rccm.200703-375OC
   Tam CS, 2010, OBES REV, V11, P118, DOI 10.1111/j.1467-789X.2009.00674.x
   Tauman R, 2007, SLEEP BREATH, V11, P77, DOI 10.1007/s11325-006-0085-7
   Verhulst SL, 2008, INT J PEDIATR OBES, V3, P234, DOI 10.1080/17477160802113548
   Verhulst SL, 2007, J PEDIATR-US, V150, P608, DOI 10.1016/j.jpeds.2007.01.051
   Verhulst SL, 2007, PEDIATR PULM, V42, P159, DOI 10.1002/ppul.20551
   Verhulst SL, 2008, SLEEP MED REV, V12, P339, DOI 10.1016/j.smrv.2007.11.002
   Verhulst SL, 2007, ARCH DIS CHILD, V92, P205, DOI 10.1136/adc.2006.101089
   Verhulst SL, 2007, CHEST, V132, P76, DOI 10.1378/chest.06-2930
   Verhulst SL, 2009, OBESITY, V17, P1178, DOI 10.1038/oby.2008.673
   Visser M, 2001, PEDIATRICS, V107, DOI 10.1542/peds.107.1.e13
   Wang JH, 2010, OTOLARYNG HEAD NECK, V142, P516, DOI 10.1016/j.otohns.2010.01.013
NR 23
TC 50
Z9 53
U1 0
U2 9
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1930-7381
J9 OBESITY
JI Obesity
PD JAN
PY 2012
VL 20
IS 1
BP 172
EP 177
DI 10.1038/oby.2011.282
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 866SB
UT WOS:000298401400020
PM 21938074
OA Bronze
DA 2025-06-11
ER

PT J
AU Alkazemi, D
   Egeland, G
   Vaya, J
   Meltzer, S
   Kubow, S
AF Alkazemi, Dalal
   Egeland, Grace
   Vaya, Jacob
   Meltzer, Sara
   Kubow, Stan
TI Oxysterol as a Marker of Atherogenic Dyslipidemia in Adolescence
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; BODY-MASS-INDEX; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   DIABETES-MELLITUS; OBESE CHILDREN; VITAMIN-E; PLASMA
AB Context: Oxysterols represent potentially important oxidative stress biomarkers in adolescence.
   Objective: The objective of the study was to examine the relationship between the concentrations of serum enzymatically and nonenzymatically generated oxysterols, measures of obesity, and metabolic components including insulin resistance and levels of blood pressure and serum lipids.
   Design: This was a cross-sectional study.
   Setting: All subjects were examined between 2003 and 2005 at a hospital, a part of a follow-up evaluation mother-daughter pairs representing pregnancies affected or unaffected by gestational diabetes that resulted in the deliveries in 1989-1991.
   Subjects: Subjects included a subset (n = 89) of the total study population of 189 adolescent girls with a mean age of 15.32 +/- 0.65 yr and body mass index of 22.54 +/- 3.98 kg/m(2).
   Main Outcome Measures: Measures included serum levels of the oxysterols 7 alpha-hydroxy-cholesterol, 7 beta-hydroxycholesterol, and 7-ketocholesterol; and body mass index, homeostasis model assessment insulin resistance index, fasting insulin, fasting glucose, blood pressure, total cholesterol, non-high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, and apolipoprotein B (ApoB).
   Results: Serum oxysterol concentrations in the adolescent cohort correlated positively with insulin (P < 0.05), total cholesterol (P < 0.05), non-high-density lipoprotein cholesterol (P < 0.05), low-density lipoprotein cholesterol (P < 0.05), and ApoB (P < 0.01). ApoB and fasting insulin were found to be the major determinants of serum oxysterols after adjustment for body mass index. Being a daughter of gestational diabetes pregnancy alone did not seem to be a predisposing factor to increased oxidative stress in our cohort.
   Conclusion: Serum oxysterol concentrations increase with obesity, insulin, and ApoB, which are established derangements associated with the metabolic syndrome. (J Clin Endocrinol Metab 93: 4282-4289, 2008)
C1 [Alkazemi, Dalal; Egeland, Grace; Kubow, Stan] McGill Univ, Sch Dietet & Human Nutr, Ste Anne De Bellevue, PQ H9X 3V9, Canada.
   [Vaya, Jacob] Migal Galilee Technol Ctr, Lab Nat Med Cpds, IL-11016 Kiryat Shmona, Israel.
   [Meltzer, Sara] McGill Univ, Ctr Hlth, Royal Victoria Hosp, Div Endocrinol & Metab,Dept Med, Montreal, PQ H3H 2R9, Canada.
C3 McGill University; McGill University; Royal Victoria Hospital
RP Kubow, S (corresponding author), McGill Univ, Sch Dietet & Human Nutr, 21 111 Lakeshore Rd, Ste Anne De Bellevue, PQ H9X 3V9, Canada.
EM stan.kubow@mcgill.ca
RI Meltzer, Sara/AAF-3564-2020; Kubow, Stan/AAJ-6913-2021; Alkazemi, Dalal
   Usamah Zaid/E-5481-2018
OI Alkazemi, Dalal Usamah Zaid/0000-0001-9349-2144; Kubow,
   Stan/0000-0001-5831-9880
FU Canadian Institutes of Health Research
FX This work was supported by a grant from the Canadian Institutes of
   Health Research.
CR Abo K, 2000, CLIN BIOCHEM, V33, P541, DOI 10.1016/S0009-9120(00)00167-3
   American Diabetes Association, 2004, Diabetes Care, V27 Suppl 1, pS5, DOI 10.2337/diacare.27.2007.S5
   Atabek ME, 2004, J PEDIATR ENDOCR MET, V17, P1063
   Björkhem I, 2002, CURR OPIN LIPIDOL, V13, P247, DOI 10.1097/00041433-200206000-00003
   Boaz M, 2005, NEPHRON CLIN PRACT, V100, pC111, DOI 10.1159/000085290
   Bougoulia Maria, 2006, Hormones (Athens), V5, P192
   Ceriello A, 2004, ARTERIOSCL THROM VAS, V24, P816, DOI 10.1161/01.ATV.0000122852.22604.78
   Cole TJ, 2000, BMJ-BRIT MED J, V320, P1240, DOI 10.1136/bmj.320.7244.1240
   Commerford SR, 2007, MOL ENDOCRINOL, V21, P3002, DOI 10.1210/me.2007-0156
   Egeland GM, 2000, BMJ-BRIT MED J, V321, P546, DOI 10.1136/bmj.321.7260.546
   Evans JL, 2005, ANTIOXID REDOX SIGN, V7, P1040, DOI 10.1089/ars.2005.7.1040
   Goran MI, 2003, J CLIN ENDOCR METAB, V88, P1417, DOI 10.1210/jc.2002-021442
   Guo SS, 2002, AM J CLIN NUTR, V76, P653, DOI 10.1093/ajcn/76.3.653
   Hansel B, 2004, J CLIN ENDOCR METAB, V89, P4963, DOI 10.1210/jc.2004-0305
   Iuliano L, 2003, ANAL BIOCHEM, V312, P217, DOI 10.1016/S0003-2697(02)00467-0
   Janssen I, 2005, OBES RES, V13, P1106, DOI 10.1038/oby.2005.129
   Keaney JF, 2003, ARTERIOSCL THROM VAS, V23, P434, DOI 10.1161/01.ATV.0000058402.34138.11
   Keskin M, 2005, PEDIATRICS, V115, pE500, DOI 10.1542/peds.2004-1921
   Knopp RH, 2006, AM J CLIN NUTR, V83, P1
   Krook A, 2006, DIABETOLOGIA, V49, P819, DOI 10.1007/s00125-006-0182-y
   KUBOW S, 1993, NUTR REV, V51, P33, DOI 10.1111/j.1753-4887.1993.tb03064.x
   LAUER RM, 1992, PEDIATRICS, V89, P495
   Luo ZC, 2006, MED HYPOTHESES, V66, P38, DOI 10.1016/j.mehy.2005.08.020
   Mohn A, 2005, J CLIN ENDOCR METAB, V90, P2653, DOI 10.1210/jc.2004-2178
   Mol MJTM, 1997, ATHEROSCLEROSIS, V129, P169, DOI 10.1016/S0021-9150(96)06022-4
   Murakami H, 2001, J Atheroscler Thromb, V8, P21
   Murakami H, 2000, LIPIDS, V35, P333, DOI 10.1007/s11745-000-0530-1
   Ninomiya JK, 2004, CIRCULATION, V109, P42, DOI 10.1161/01.CIR.0000108926.04022.0C
   Olkkonen VM, 2004, ANN MED, V36, P562, DOI 10.1080/07853890410018907
   Patel RP, 1996, J LIPID RES, V37, P2361
   Peters AL, 2008, Clin Diabetes 1 January, V26, P3, DOI DOI 10.2337/DIACLIN.26.1.3
   Reaven GM, 2005, J THROMB HAEMOST, V3, P1074, DOI 10.1111/j.1538-7836.2005.01277.x
   Salonen JT, 1997, CIRCULATION, V95, P840
   Shields Margot, 2006, Health Rep, V17, P27
   Sjogren P, 2005, ARTERIOSCL THROM VAS, V25, P2580, DOI 10.1161/01.ATV.0000190675.08857.3d
   Sniderman AD, 2007, CURR OPIN LIPIDOL, V18, P633, DOI 10.1097/MOL.0b013e3282f0dd33
   Steinberger J, 2003, CURR OPIN LIPIDOL, V14, P555, DOI 10.1097/00041433-200312000-00002
   Vaya J, 2001, FREE RADICAL RES, V34, P485, DOI 10.1080/10715760100300431
   Weinbrenner T, 2006, AM J CLIN NUTR, V83, P30
   Ziedén B, 1999, ARTERIOSCL THROM VAS, V19, P967, DOI 10.1161/01.ATV.19.4.967
NR 40
TC 50
Z9 51
U1 0
U2 3
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD NOV
PY 2008
VL 93
IS 11
BP 4282
EP 4289
DI 10.1210/jc.2008-0586
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 368ZI
UT WOS:000260661900018
PM 18713821
DA 2025-06-11
ER

PT J
AU Tan, RYM
   Grigg, J
   Kulkarni, J
AF Tan, Raelene Y. M.
   Grigg, Jasmin
   Kulkarni, Jayashri
TI Borderline personality disorder and polycystic ovary syndrome: A review
   of the literature
SO AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
LA English
DT Review
DE Borderline personality disorder; psychiatric disorder; polycystic ovary
   syndrome; testosterone; hyperandrogenism
ID ADRENAL ANDROGEN EXCESS; CORTICOTROPIN-RELEASING-FACTOR; CHILDHOOD
   EXPERIENCES; COMMUNITY SAMPLE; RISK-FACTORS; TESTOSTERONE LEVELS;
   METABOLIC SYNDROME; LIFE EVENTS; WOMEN; PREVALENCE
AB Objective: This review examines the existing evidence for the relationship between borderline personality disorder and polycystic ovary syndrome, and to identify commonalities in etiological mechanisms of borderline personality disorder and polycystic ovary syndrome that might explain the relationship between these seemingly disparate disorders.
   Methods: A search of Medline, EMBASE and Cochrane Central was undertaken on 5 December 2016 to identify studies investigating women with borderline personality disorder and polycystic ovary syndrome (or symptoms and markers specific to polycystic ovary syndrome).
   Results: Nine studies were identified, including three cross-sectional studies investigating symptoms of polycystic ovary syndrome in women with borderline personality disorder, two cross-sectional and one cohort study examining the prevalence of psychiatric diagnoses in women with polycystic ovary syndrome and three case reports of comorbid borderline personality disorder and polycystic ovary syndrome.
   Conclusion: Overall, the literature shows women with borderline personality disorder to have higher than expected serum androgen levels and incidence of polycystic ovaries, which can be key features of polycystic ovary syndrome. However, this research is still in its infancy, which limits our understanding of this potential comorbid phenomenon. Given the emerging anecdotal and empirical evidence to date, a theoretical discussion of the potential psychoneuroendocrinological mechanism underlying the borderline personality disorder and polycystic ovary syndrome comorbidity is provided. Further rigorous studies using standardized diagnostic criteria for polycystic ovary syndrome are warranted. Specifically, the use of prospective controlled cohort studies may be able to determine the causality and temporality of observed comorbid borderline personality disorder and polycystic ovary syndrome.
C1 [Tan, Raelene Y. M.; Grigg, Jasmin; Kulkarni, Jayashri] Monash Alfred Psychiat Res Ctr MAPrc, Level 4,607 St Kilda Rd, Melbourne, Vic 3004, Australia.
   [Tan, Raelene Y. M.] Monash Univ, Melbourne, Vic, Australia.
C3 Monash University; Monash University
RP Kulkarni, J (corresponding author), Monash Alfred Psychiat Res Ctr MAPrc, Level 4,607 St Kilda Rd, Melbourne, Vic 3004, Australia.
EM jayashri.kulkarni@monash.edu
CR Annagür BB, 2013, J PSYCHOSOM RES, V74, P244, DOI 10.1016/j.jpsychores.2013.01.002
   [Anonymous], J PSYCHIAT
   [Anonymous], J ROYAL SOC MED OPEN
   [Anonymous], END ABSTR
   [Anonymous], 1992, POLYCYSTIC OVARY SYN
   Arborelius L, 1999, J ENDOCRINOL, V160, P1, DOI 10.1677/joe.0.1600001
   Azziz R, 1998, J CLIN ENDOCR METAB, V83, P2317, DOI 10.1210/jc.83.7.2317
   Azziz R, 2000, ENDOCRINOLOGIST, V10, P245, DOI 10.1097/00019616-200010040-00006
   Azziz R, 2009, FERTIL STERIL, V91, P456, DOI 10.1016/j.fertnstert.2008.06.035
   Bandelow B, 2005, PSYCHIAT RES, V134, P169, DOI 10.1016/j.psychres.2003.07.008
   Barnard L, 2007, PSYCHONEUROENDOCRINO, V32, P906, DOI 10.1016/j.psyneuen.2007.06.010
   Barry JA, 2014, HUM REPROD UPDATE, V20, P748, DOI 10.1093/humupd/dmu012
   Barthelmess Erin K, 2014, Front Biosci (Elite Ed), V6, P104
   Benson S, 2009, PSYCHONEUROENDOCRINO, V34, P727, DOI 10.1016/j.psyneuen.2008.12.001
   Benson S, 2009, HUM REPROD, V24, P1446, DOI 10.1093/humrep/dep031
   Benson S, 2010, JOGNN-J OBST GYN NEO, V39, P37, DOI 10.1111/j.1552-6909.2009.01086.x
   Berne RobertM., 2008, Berne Levy Physiology
   Black DW, 2004, J PERS DISORD, V18, P226, DOI 10.1521/pedi.18.3.226.35445
   Brambilla P, 2004, PSYCHIAT RES-NEUROIM, V131, P125, DOI 10.1016/j.pscychresns.2004.04.003
   Burger HG, 2002, FERTIL STERIL, V77, pS3
   CARMINA E, 1990, GYNECOL ENDOCRINOL, V4, P225, DOI 10.3109/09513599009024976
   Carpenter LL, 2007, BIOL PSYCHIAT, V62, P1080, DOI 10.1016/j.biopsych.2007.05.002
   Carrasco JL, 2007, BRIT J PSYCHIAT, V190, P357, DOI 10.1192/bjp.bp.106.022590
   Carter MJ, 2014, THER RECREAT J, V48, P275
   Cesta CE, 2016, PSYCHONEUROENDOCRINO, V73, P196, DOI 10.1016/j.psyneuen.2016.08.005
   Chang J, 2004, FERTIL STERIL, V81, P19, DOI 10.1016/j.fertnstert.2003.10.004
   Choi-Kain LW, 2016, HARVARD REV PSYCHIAT, V24, P342, DOI 10.1097/HRP.0000000000000113
   DeSoto MC, 2003, PSYCHONEUROENDOCRINO, V28, P751, DOI 10.1016/S0306-4530(02)00068-9
   Dettenborn L, 2016, PSYCHONEUROENDOCRINO, V71, P176, DOI 10.1016/j.psyneuen.2016.05.026
   Dixon-Gordon KL, 2015, CAN PSYCHOL, V56, P168, DOI 10.1037/cap0000024
   Enea C, 2011, SPORTS MED, V41, P1, DOI 10.2165/11536920-000000000-00000
   Fauser BCJM, 2012, FERTIL STERIL, V97, P28, DOI 10.1016/j.fertnstert.2011.09.024
   Fernand SC, 2012, PSYCHONEUROENDOCRINO, V37, P1659, DOI 10.1016/j.psyneuen.2012.02.012
   Fonagy P, 2011, INFANT MENT HEALTH J, V32, P47, DOI 10.1002/imhj.20283
   Frankenburg FR, 2011, J PERS DISORD, V25, P421, DOI 10.1521/pedi.2011.25.4.421
   Goodarzi MO, 2011, NAT REV ENDOCRINOL, V7, P219, DOI 10.1038/nrendo.2010.217
   Goodman LA, 1997, SCHIZOPHRENIA BULL, V23, P685, DOI 10.1093/schbul/23.4.685
   Goodman M, 2011, J PSYCHIATR RES, V45, P803, DOI 10.1016/j.jpsychires.2010.11.011
   Gottschau M, 2015, GYNECOL ONCOL, V136, P99, DOI 10.1016/j.ygyno.2014.11.012
   Grant BF, 2008, J CLIN PSYCHIAT, V69, P533, DOI 10.4088/JCP.v69n0404
   Hahn S, 2006, HUM REPROD, V21, P1925, DOI 10.1093/humrep/del069
   Heim C., 2003, FOCUS J LIFELONG LEA, V1, P282
   Jain S, 2015, INDIAN J PSYCHIAT, V57, pS73
   JOHNSON EO, 1992, NEUROSCI BIOBEHAV R, V16, P115, DOI 10.1016/S0149-7634(05)80175-7
   Johnson JK, 2007, EUR J OBSTET GYN R B, V133, P95, DOI 10.1016/j.ejogrb.2006.04.035
   Jovev M, 2006, J PERS DISORD, V20, P205, DOI 10.1521/pedi.2006.20.3.205
   Joyce PR, 2003, AUST NZ J PSYCHIAT, V37, P756, DOI 10.1111/j.1440-1614.2003.01263.x
   Kahl KG, 2013, EUR ARCH PSY CLIN N, V263, P205, DOI 10.1007/s00406-012-0339-2
   Kaliray P., 2004, OBSTET GYNAECOLOGIST, V6, P209, DOI DOI 10.1576/T0AG.6.4.209.27017
   Kerchner A, 2009, FERTIL STERIL, V91, P207, DOI 10.1016/j.fertnstert.2007.11.022
   Kumar A, 2005, CLIN ENDOCRINOL, V62, P644, DOI 10.1111/j.1365-2265.2005.02256.x
   Kuo JR, 2009, J ABNORM PSYCHOL, V118, P531, DOI 10.1037/a0016392
   Lanzone A, 1996, CLIN ENDOCRINOL, V45, P73, DOI 10.1046/j.1365-2265.1996.768573.x
   Leeb R.T., 2008, CHILD MALTREATMENT
   Leichsenring F, 2011, LANCET, V377, P74, DOI 10.1016/S0140-6736(10)61422-5
   Levin Kate Ann, 2006, Evid Based Dent, V7, P24, DOI 10.1038/sj.ebd.6400375
   Li YA, 2011, FERTIL STERIL, V96, P452, DOI 10.1016/j.fertnstert.2011.05.072
   Lieb K, 2004, J PSYCHIATR RES, V38, P559, DOI 10.1016/j.jpsychires.2004.04.002
   Lupien SJ, 2009, NAT REV NEUROSCI, V10, P434, DOI 10.1038/nrn2639
   March WA, 2010, HUM REPROD, V25, P544, DOI 10.1093/humrep/dep399
   Martín-Blanco A, 2014, COMPR PSYCHIAT, V55, P311, DOI 10.1016/j.comppsych.2013.08.026
   McFarlane A, 2006, AUST NZ J PSYCHIAT, V40, P1010, DOI 10.1080/j.1440-1614.2006.01925.x
   Milutinovic DV, 2011, EXP CLIN ENDOCR DIAB, V119, P636, DOI 10.1055/s-0031-1283122
   Moran LJ, 2010, HUM REPROD UPDATE, V16, P347, DOI 10.1093/humupd/dmq001
   Paris J, 2009, ANNU REV CLIN PSYCHO, V5, P277, DOI 10.1146/annurev.clinpsy.032408.153457
   Quirk SE, 2017, AUST NZ J PSYCHIAT, V51, P141, DOI 10.1177/0004867416649032
   Rausch J, 2015, PSYCHONEUROENDOCRINO, V55, P116, DOI 10.1016/j.psyneuen.2015.02.002
   Rees DA, 2016, J CLIN ENDOCR METAB, V101, P313, DOI 10.1210/jc.2015-2318
   Rinne T, 2002, BIOL PSYCHIAT, V52, P1102, DOI 10.1016/S0006-3223(02)01395-1
   Roepke S, 2010, J PSYCHIATR RES, V44, P847, DOI 10.1016/j.jpsychires.2010.01.007
   Sahingöz M, 2013, GEN HOSP PSYCHIAT, V35, P508, DOI 10.1016/j.genhosppsych.2013.04.003
   Scaruffi E, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00185
   Schattmann L, 2007, HORM BEHAV, V51, P587, DOI 10.1016/j.yhbeh.2007.02.007
   Schliep KC, 2016, HUM REPROD, V31, P1904, DOI 10.1093/humrep/dew153
   Schmahl CG, 2003, PSYCHIAT RES-NEUROIM, V122, P193, DOI 10.1016/S0925-4927(03)00023-4
   Sundermann JM, 2013, J TRAUMA DISSOCIATIO, V14, P69, DOI 10.1080/15299732.2012.710186
   Teede H, 2010, BMC MED, V8, DOI 10.1186/1741-7015-8-41
   Tomko RL, 2014, J PERS DISORD, V28, P734, DOI 10.1521/pedi_2012_26_093
   Toufexis D, 2014, J NEUROENDOCRINOL, V26, P573, DOI 10.1111/jne.12179
   Trisno R, 2016, AUST NZ J PSYCHIAT, V50, P385, DOI 10.1177/0004867415615950
   Trull TJ, 2010, J PERS DISORD, V24, P412, DOI 10.1521/pedi.2010.24.4.412
   Waxman R, 2014, PERSONAL MENT HEALTH, V8, P30, DOI 10.1002/pmh.1239
   Whittle S, 2009, PSYCHIAT RES-NEUROIM, V172, P155, DOI 10.1016/j.pscychresns.2008.12.004
   Zanarini MC, 2000, J PERS DISORD, V14, P264, DOI 10.1521/pedi.2000.14.3.264
   Zanarini MC, 2000, PSYCHIAT CLIN N AM, V23, P89, DOI 10.1016/S0193-953X(05)70145-3
   Zanarini MC, 1997, AM J PSYCHIAT, V154, P1101
   Zhang L, 2016, EUR J OBSTET GYN R B, V202, P26, DOI 10.1016/j.ejogrb.2016.04.038
NR 87
TC 14
Z9 16
U1 0
U2 21
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0004-8674
EI 1440-1614
J9 AUST NZ J PSYCHIAT
JI Aust. N. Z. J. Psych.
PD FEB
PY 2018
VL 52
IS 2
BP 117
EP 128
DI 10.1177/0004867417730650
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FV0FQ
UT WOS:000424231800005
PM 28891300
OA Bronze
DA 2025-06-11
ER

PT J
AU Trattner, H
   Blüml, S
   Steiner, I
   Plut, U
   Radakovic, S
   Tanew, A
AF Trattner, H.
   Blueml, S.
   Steiner, I.
   Plut, U.
   Radakovic, S.
   Tanew, A.
TI Quality of life and comorbidities in palmoplantar pustulosis - a
   cross-sectional study on 102 patients
SO JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
LA English
DT Article
ID TISSUE TRANSGLUTAMINASE; PSORIASIS; HEALTH; PREVALENCE; INFECTION; RISK
AB BackgroundAssociation of palmoplantar pustulosis (PPP) with metabolic and autoimmune diseases has been reported in mostly small case series or anecdotal cases.
   ObjectiveTo assess health-related quality of life and prevalence of comorbidities in a large cohort of PPP patients.
   MethodsWe conducted a cross-sectional study on patients with either active or past PPP. Disease severity was measured by the Palmoplantar Pustulosis Area and Severity Index (ppPASI). Quality of life was assessed by the Dermatology Life Quality Index (DLQI). Comorbidities were evaluated by medical history, blood examination, stool testing for Helicobacter pylori antigen and screening tools for depression and psoriatic arthritis.
   ResultsA total of 102 patients (87 women, 15 men) with a mean age of 52.614.1years were evaluated. The mean DLQI was 7 +/- 6. Comorbidities were frequent and consisted of hypercholesterolaemia (38%), hypertension (32%), obesity (27%), metabolic syndrome (26%), depression (24%), diabetes (19%), autoimmune thyroiditis (16%) and psoriatic arthritis (16%).
   ConclusionPatients with PPP have an impaired quality of life and a broad range of comorbidities. Contrary to other reports, our investigation failed to show an association between PPP and coeliac disease or H.pylori infection.
C1 [Trattner, H.; Plut, U.; Radakovic, S.; Tanew, A.] Med Univ Vienna, Dept Dermatol, Vienna, Austria.
   [Blueml, S.] Med Univ Vienna, Dept Rheumatol, Vienna, Austria.
   [Steiner, I.] Med Univ Vienna, Ctr Med Stat Informat & Intelligent Syst, Sect Med Stat, Vienna, Austria.
C3 Medical University of Vienna; Medical University of Vienna; Medical
   University of Vienna
RP Trattner, H (corresponding author), Med Univ Vienna, Dept Dermatol, Vienna, Austria.
EM hannes.trattner@meduniwien.ac.at
OI Trattner, Hannes/0000-0002-1706-0726; Bluml,
   Stephan/0000-0002-2758-4400; Tanew, M.D., Adrian/0000-0002-4433-2790
CR [Anonymous], 2015, STAT AUSTRIA
   Brunasso AMG, 2013, BRIT J DERMATOL, V168, P1243, DOI 10.1111/bjd.12223
   Campanati A, 2015, INT J DERMATOL, V54, pE109, DOI 10.1111/ijd.12798
   Christophers E, 2010, J EUR ACAD DERMATOL, V24, P548, DOI 10.1111/j.1468-3083.2009.03463.x
   Chung JN, 2014, J AM ACAD DERMATOL, V71, P623, DOI 10.1016/j.jaad.2014.04.063
   Cohen BE, 2016, JAMA DERMATOL, V152, P73, DOI 10.1001/jamadermatol.2015.3605
   Dieterich W, 1998, GASTROENTEROLOGY, V115, P1317, DOI 10.1016/S0016-5085(98)70007-1
   Eriksson MO, 1998, BRIT J DERMATOL, V138, P390
   American Heart Association, 2005, Cardiol Rev, V13, P322
   Hagforsen E, 2005, ACTA DERM-VENEREOL, V85, P225, DOI 10.1080/00015550510026587
   Hagforsen E, 2007, ACTA DERM-VENEREOL, V87, P261, DOI 10.2340/00015555-0217
   Hübner AM, 2008, CLIN EXP DERMATOL, V33, P339, DOI 10.1111/j.1365-2230.2007.02634.x
   Kikuchi N, 2013, ACTA DERM-VENEREOL, V93, P721, DOI 10.2340/00015555-1552
   Michaëlsson G, 2007, BRIT J DERMATOL, V156, P659, DOI 10.1111/j.1365-2133.2006.07725.x
   Mustalahti K, 2010, ANN MED, V42, P587, DOI 10.3109/07853890.2010.505931
   ROSEN K, 1988, J AM ACAD DERMATOL, V19, P1009, DOI 10.1016/S0190-9622(88)70265-0
   Sáez-Rodríguez M, 2002, CLIN EXP DERMATOL, V27, P720, DOI 10.1046/j.1365-2230.2002.01102_6.x
   Takahara M, 2011, ADV OTO-RHINO-LARYNG, V72, P86, DOI 10.1159/000324618
   Volker D, 2016, J OCCUP REHABIL, V26, P237, DOI 10.1007/s10926-015-9607-0
   Weisenseel P, 2007, BRIT J DERMATOL, V156, P1399, DOI 10.1111/j.1365-2133.2007.07908.x
   Yanagi T, 2005, LANCET, V366, P1050, DOI 10.1016/S0140-6736(05)67384-9
NR 21
TC 44
Z9 47
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0926-9959
EI 1468-3083
J9 J EUR ACAD DERMATOL
JI J. Eur. Acad. Dermatol. Venereol.
PD OCT
PY 2017
VL 31
IS 10
BP 1681
EP 1685
DI 10.1111/jdv.14187
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FK5ZM
UT WOS:000413582400045
PM 28252813
DA 2025-06-11
ER

PT J
AU Paruthiyil, S
   Hagiwara, S
   Kundassery, K
   Bhargava, A
AF Paruthiyil, Sreenivasan
   Hagiwara, Shin-ichiro
   Kundassery, Keshav
   Bhargava, Aditi
TI Sexually dimorphic metabolic responses mediated by CRF2
   receptor during nutritional stress in mice
SO BIOLOGY OF SEX DIFFERENCES
LA English
DT Article
DE Blood glucose; Dyslipidemia; Fat mass; Hepatic steatosis; Plasma insulin
ID CORTICOTROPIN-RELEASING-FACTOR; INSULIN-RESISTANCE; GLUCAGON-SECRETION;
   ENERGY-BALANCE; MESSENGER-RNA; EXPRESSION; HORMONE; MECHANISMS;
   INFLAMMATION; ISLETS
AB BackgroundChronic stress is a major contributor in the development of metabolic syndrome and associated diseases, such as diabetes. High-fat diet (HFD) and sex are known modifiers of metabolic parameters. Peptide hormones corticotropin-releasing factor (CRF) and urocortins (UCN) mediate stress responses via activation and feedback to the hypothalamic-pituitary-adrenal (HPA) axis. UCN3 is a marker of pancreatic -cell differentiation, and UCN2 is known to ameliorate glucose levels in mice rendered diabetic with HFD. CRF receptor 2 (CRF2) is the only known cognate receptor for UCN2/3. Here, we ascertained the role of CRF2 in glucose clearance, insulin sensitivity, and other parameters associated with metabolic syndrome in a mouse model of nutritional stress.MethodsWild-type (WT) and Crhr2(-/-) (null) mice of both sexes were fed either normal chow diet or HFD. After 8weeks, blood glucose levels in response to glucose and insulin challenge were determined. Change in body and fat mass, plasma insulin, and lipid profile were assessed. Histological evaluation of liver sections was performed.ResultsHere, we show that genotype (Crhr2), sex, and diet were all independent variables in the regulation of blood glucose levels, body and fat mass gain/redistribution, and insulin resistance. Surprisingly, CRF2-deficient mice (Crhr2(-/-)) male mice showed similarly impaired glucose clearance on HFD and chow. HFD-fed female Crhr2(-/-) mice redistributed their fat depots that were distinct from wild-type females and male mice on either diet. Blood cholesterol and low-density lipoprotein (LDL) levels were elevated significantly in male Crhr2(-/-) mice; female Crhr2(-/-) mice were protected. Male, but not female Crhr2(-/-) mice developed peripheral insulin resistance. HFD, but not chow-fed wild-type male mice developed hepatic macrovesicular steatosis. In contrast, livers of Crhr2(-/-) male mice showed microvesicular steatosis on either diet, whereas livers of female mice on this 8-week HFD regimen did not develop steatosis.ConclusionsCRF(2) receptor dysregulation is a sexually dimorphic risk factor in development of pre-diabetic and metabolic symptoms.
C1 [Bhargava, Aditi] Univ Calif San Francisco, Dept Obstet & Gynecol, Ctr Reprod Sci, 513 Parnassus Ave,HSE1645,Box 0556, San Francisco, CA 94143 USA.
   Univ Calif San Francisco, Osher Ctr Integrat Med, 513 Parnassus Ave,HSE1645,Box 0556, San Francisco, CA 94143 USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco
RP Bhargava, A (corresponding author), Univ Calif San Francisco, Dept Obstet & Gynecol, Ctr Reprod Sci, 513 Parnassus Ave,HSE1645,Box 0556, San Francisco, CA 94143 USA.
EM Aditi.bhargava@ucsf.edu
OI Bhargava, Aditi/0000-0003-1334-0517; Kundassery,
   Keshav/0000-0002-1218-1940
FU NIH from UCSF Diabetes Center [P30-DK063720];  [DK R56-080787]
FX This work was funded in part by a NIH grant P30-DK063720 awarded as a
   pilot grant from UCSF Diabetes Center to AB and DK R56-080787 (AB).
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   Bale TL, 2004, ANNU REV PHARMACOL, V44, P525, DOI 10.1146/annurev.pharmtox.44.101802.121410
   Bale TL, 2000, NAT GENET, V24, P410, DOI 10.1038/74263
   Bergmann N, 2014, ENDOCR CONNECT, V3, pR55, DOI 10.1530/EC-14-0031
   Brown MS, 2008, CELL METAB, V7, P95, DOI 10.1016/j.cmet.2007.12.009
   Catalano KJ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0108693
   Chang J, 2007, PEPTIDES, V28, P1453, DOI 10.1016/j.peptides.2007.05.008
   Coste SC, 2000, NAT GENET, V24, P403, DOI 10.1038/74255
   Eraslan E, 2015, NOISE HEALTH, V17, P141, DOI 10.4103/1463-1741.155838
   Farese RV, 2012, CELL METAB, V15, P570, DOI 10.1016/j.cmet.2012.03.004
   Fellmann L, 2013, PHARMACOL THERAPEUT, V137, P331, DOI 10.1016/j.pharmthera.2012.11.004
   Gai ZH, 2016, J NEUROL SCI, V368, P307, DOI 10.1016/j.jns.2016.07.049
   Gao MH, 2016, JCI INSIGHT, V1, DOI 10.1172/jci.insight.88322
   Gluchowski NL, 2017, NAT REV GASTRO HEPAT, V14, P343, DOI 10.1038/nrgastro.2017.32
   Harris RBS, 2015, AM J PHYSIOL-REG I, V308, pR250, DOI 10.1152/ajpregu.00361.2014
   Hasdemir B, 2017, MOL BIOL CELL, V28, P2386, DOI 10.1091/mbc.E16-11-0778
   Hasdemir B, 2016, AM J PHYSIOL-REG I, V310, pR1244, DOI 10.1152/ajpregu.00445.2015
   Hasdemir B, 2012, MOL ENDOCRINOL, V26, P681, DOI 10.1210/me.2011-1361
   Hjemdahl P, 2002, CIRCULATION, V106, P2634, DOI 10.1161/01.CIR.0000041502.43564.79
   Ingvorsen C, 2017, NUTR DIABETES, V7, DOI 10.1038/nutd.2017.6
   Kawamori D, 2009, CELL METAB, V9, P350, DOI 10.1016/j.cmet.2009.02.007
   Kubat E, 2013, MOL MED, V19, P212, DOI 10.2119/molmed.2013.00036
   Kumashiro N, 2011, P NATL ACAD SCI USA, V108, P16381, DOI 10.1073/pnas.1113359108
   la Fleur SE, 2005, P NATL ACAD SCI USA, V102, P7647, DOI 10.1073/pnas.0408531102
   Lai NC, 2015, HUM GENE THER, V26, P347, DOI 10.1089/hum.2014.157
   Laugero KD, 2001, ENDOCRINOLOGY, V142, P2796, DOI 10.1210/en.142.7.2796
   Lichtenstein AH, 2000, ATHEROSCLEROSIS, V150, P227, DOI 10.1016/S0021-9150(99)00504-3
   Mahajan S, 2014, PEPTIDES, V54, P58, DOI 10.1016/j.peptides.2014.01.007
   MARUYAMA H, 1984, J CLIN INVEST, V74, P2296, DOI 10.1172/JCI111658
   MCCLURE TJ, 1963, NATURE, V199, P504, DOI 10.1038/199504b0
   MORAN TH, 2005, METHODS STUDY CONTRO
   Pecoraro N, 2006, PROG NEUROBIOL, V79, P247, DOI 10.1016/j.pneurobio.2006.07.004
   Reaven G M, 1997, Nutrition, V13, P66
   Roglic G, 2015, DIABETES RES CLIN PR, V108, P367, DOI 10.1016/j.diabres.2015.03.010
   Salehi A, 2006, DIABETES, V55, P2318, DOI 10.2337/db06-0080
   Samuel VT, 2012, CELL, V148, P852, DOI 10.1016/j.cell.2012.02.017
   Shanik MH, 2008, DIABETES CARE, V31, pS262, DOI 10.2337/dc08-s264
   Shulman GI, 2000, J CLIN INVEST, V106, P171, DOI 10.1172/JCI10583
   Strowski MZ, 2000, ENDOCRINOLOGY, V141, P111, DOI 10.1210/en.141.1.111
   Tao ZQ, 2015, CELL BIOCHEM BIOPHYS, V73, P181, DOI 10.1007/s12013-015-0598-4
   Tsuda T, 2017, J EXP MED, V214, P1877, DOI 10.1084/jem.20161924
   van der Meulen T, 2015, NAT MED, V21, P769, DOI 10.1038/nm.3872
   Winzell MS, 2004, DIABETES, V53, pS215, DOI 10.2337/diabetes.53.suppl_3.S215
NR 43
TC 23
Z9 24
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2042-6410
J9 BIOL SEX DIFFER
JI Biol. Sex Differ.
PD NOV 6
PY 2018
VL 9
AR 49
DI 10.1186/s13293-018-0208-4
PG 16
WC Endocrinology & Metabolism; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Genetics & Heredity
GA GZ4CD
UT WOS:000449339100001
PM 30400826
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Anderson, G
   Maes, M
AF Anderson, George
   Maes, Michael
TI Gut Dysbiosis Dysregulates Central and Systemic Homeostasis via
   Suboptimal Mitochondrial Function: Assessment, Treatment and
   Classification Implications
SO CURRENT TOPICS IN MEDICINAL CHEMISTRY
LA English
DT Review
DE Butyrate; Gut permeability; Microbiome; Mitochondria; Immune; Melatonin;
   Classification; Psychiatry; Treatment; Stress
ID CATABOLITE TRYCAT PATHWAY; NF-KAPPA-B; NITROSATIVE STRESS; TRYPTOPHAN
   CATABOLITE; PRENATAL STRESS; INFLAMMATORY RESPONSE; NICOTINIC RECEPTOR;
   MULTIPLE-SCLEROSIS; METABOLIC SYNDROME; MAJOR DEPRESSION
AB The gut and mitochondria have emerged as two important hubs at the cutting edge of research across a diverse array of medical conditions, including most psychiatric conditions. This article highlights the interaction of the gut and mitochondria over the course of development, with an emphasis on the consequences for transdiagnostic processes across psychiatry, but with relevance to wider medical conditions. As well as raised levels of circulating lipopolysaccharide (LPS) arising from increased gut permeability, the loss of the short-chain fatty acid, butyrate, is an important mediator of how gut dysbiosis modulates mitochondrial function. Reactive cells, central glia and systemic immune cells are also modulated by the gut, in part via impacts on mitochondrial function in these cells. Gut-driven alterations in the activity of reactive cells over the course of development are proposed to be an important determinant of the transdiagnostic influence of glia and the immune system. Stress, including prenatal stress, also acts via the gut. The suppression of butyrate, coupled to raised LPS, drives oxidative and nitrosative stress signalling that culminates in the activation of acidic sphingomyelinase-induced ceramide. Raised ceramide levels negatively regulate mitochondrial function, both directly and via its negative impact on daytime, arousal-promoting orexin and night-time sleep-promoting pineal gland-derived melatonin. Both orexin and melatonin positively regulate mitochondria oxidative phosphorylation. Consequently, gut-mediated increases in ceramide have impacts on the circadian rhythm and the circadian regulation of mitochondrial function. Butyrate, orexin and melatonin can positively regulate mitochondria via the disinhibition of the pyruvate dehydrogenase complex, leading to increased conversion of pyruvate to acetyl-CoA. Acetyl-CoA is a necessary co-substrate for the initiation of the melatonergic pathway in mitochondria and therefore the beneficial effects of mitochondria melatonin synthesis on mitochondrial function. This has a number of treatment implications across psychiatric and wider medical conditions, including the utilization of sodium butyrate and melatonin.
   Overall, gut dysbiosis and increased gut permeability have significant impacts on central and systemic homeostasis via the regulation of mitochondrial function, especially in central glia and systemic immune cells.
C1 [Anderson, George] CRC Scotland & London, Eccleston Sq, London, England.
   [Maes, Michael] Chulalongkorn Univ, Dept Psychiat, Bangkok, Thailand.
   [Maes, Michael] Deakin Univ, IMPACT Strateg Res Ctr, Geelong, Vic, Australia.
C3 Chulalongkorn University; Deakin University
RP Anderson, G (corresponding author), CRC Scotland & London, Eccleston Sq, London, England.
EM anderson.george@rocketmail.com
RI Maes, Michael/B-8546-2011; Anderson, George/AEO-3626-2022
OI Anderson, George/0000-0001-7243-0817
CR Anderson G, 2010, INT J TRYPTOPHAN RES, V3, P169, DOI 10.4137/IJTR.S4603
   Anderson G., 2015, COENZYME Q10 FACT FI, P147
   Anderson G., 2019, MELATONIN RES, V2, P1, DOI 10.32794/mr11250037
   Anderson G., 2018, NEUROPROGRESSION PSY
   ANDERSON G, 2020, BIOL PSYCHIAT, V98, DOI DOI 10.1016/J.PNPBP.2019.109782
   Anderson G., 2019, Melatonin Research, V2, P70, DOI [10.32794/mr11250022, DOI 10.32794/MR11250022]
   Anderson G, 2019, CURR PHARM DESIGN, V25, P4321, DOI 10.2174/1381612825666191102170125
   Anderson G, 2019, CURR PHARM DESIGN, V25, P3550, DOI 10.2174/1381612825666190920114611
   Anderson G, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20164068
   Anderson George, 2019, BioMolecular Concepts, V10, P133, DOI 10.1515/bmc-2019-0017
   Anderson G, 2019, INT J TRYPTOPHAN RES, V12, DOI 10.1177/1178646919855942
   Anderson G, 2018, INFLAMMATION AND IMMUNITY IN DEPRESSION: BASIC SCIENCE AND CLINICAL APPLICATIONS, P549, DOI 10.1016/B978-0-12-811073-7.00032-5
   Anderson G, 2018, PROG NEURO-PSYCHOPH, V80, P255, DOI 10.1016/j.pnpbp.2017.04.022
   Anderson George, 2017, BioMolecular Concepts, V8, P185, DOI 10.1515/bmc-2017-0009
   Anderson G, 2017, CNS NEUROL DISORD-DR, V16, P266, DOI 10.2174/1871527315666161122144659
   Anderson G, 2017, INT J TRYPTOPHAN RES, V10, DOI 10.1177/1178646917691738
   Anderson G, 2016, CURR PHARM DESIGN, V22, P6142, DOI 10.2174/1381612822666160906161513
   Anderson G, 2015, ADV INTEGR MED, V2, P31, DOI 10.1016/j.aimed.2014.12.007
   Anderson G, 2013, PROG NEURO-PSYCHOPH, V42, P5, DOI 10.1016/j.pnpbp.2012.06.014
   Anderson G, 2011, MED HYPOTHESES, V76, P54, DOI 10.1016/j.mehy.2010.08.029
   Angajala A, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.01605
   [Anonymous], 2016, BRIT J NUTR
   Anthony D, 2020, ANTIOXID REDOX SIGN, V32, P943, DOI 10.1089/ars.2018.7716
   Aon MA, 2016, CLIN SCI, V130, P1285, DOI 10.1042/CS20160002
   Asencio C, 2016, EUR J HUM GENET, V24, P367, DOI 10.1038/ejhg.2015.112
   Asor E, 2012, WORLD J PSYCHIATR, V2, P124, DOI 10.5498/wjp.v2.i6.124
   Baran H, 2016, INT J TRYPTOPHAN RES, V9, P17, DOI [10.4137/ijtr.s37973, 10.4137/IJTR.S37973]
   Barandas R, 2015, CURR PSYCHIAT REP, V17, DOI 10.1007/s11920-015-0637-2
   Brannigan R, 2020, BRIT J PSYCHIAT, V216, P85, DOI 10.1192/bjp.2019.190
   Brunkhorst-Kanaan N, 2019, METABOLISM, V95, P65, DOI 10.1016/j.metabol.2019.04.002
   Calarge CA, 2019, J AFFECT DISORDERS, V246, P586, DOI 10.1016/j.jad.2018.12.077
   Castillo SS, 2007, EXP CELL RES, V313, P2680, DOI 10.1016/j.yexcr.2007.04.002
   Chen K, 2019, FOOD FUNCT, V10, P814, DOI [10.1039/c8fo01236a, 10.1039/C8FO01236A]
   Chen L, 2019, INFLAMM BOWEL DIS, V25, P1450, DOI 10.1093/ibd/izz046
   Chen YN, 2018, MOL MED REP, V17, P6122, DOI 10.3892/mmr.2018.8613
   Chen Y, 2019, BIOCHEM BIOPH RES CO, V509, P767, DOI 10.1016/j.bbrc.2018.12.180
   Cikánková T, 2017, CNS NEUROL DISORD-DR, V16, P176, DOI 10.2174/1871527315666161213110518
   Cleophas MCP, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-37246-7
   Codagnone MG, 2019, BIOL PSYCHIAT, V85, P150, DOI 10.1016/j.biopsych.2018.06.014
   Cowan CSM, 2018, BIOESSAYS, V40, DOI 10.1002/bies.201700172
   Dadic-Hero E, 2010, PSYCHIAT DANUB, V22, P381
   Dai S.-H., 2017, FREE RADICAL BIO MED, V108, P345, DOI [10.1016/j.freeradbiomed.2017.04.005, DOI 10.1016/j.freeradbiomed.2017.04.005]
   Dai YL, 2011, ATHEROSCLEROSIS, V216, P395, DOI 10.1016/j.atherosclerosis.2011.02.013
   Ding K, 2014, NEUROCHEM INT, V76, P23, DOI 10.1016/j.neuint.2014.06.015
   Donnadieu-Rigole H, 2018, ALCOHOL CLIN EXP RES, V42, P32, DOI 10.1111/acer.13527
   Duan JJ, 2019, CELL SIGNAL, V58, P44, DOI 10.1016/j.cellsig.2019.03.007
   Endo H, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0063388
   Escames G, 2019, Melatonin Res, V2, P105, DOI DOI 10.32794/MR11250033
   Fang XY, 2019, PSYCHIAT RES, V281, DOI 10.1016/j.psychres.2019.112522
   Fatima M, 2017, INT J DEV NEUROSCI, V60, P1, DOI 10.1016/j.ijdevneu.2017.04.001
   Febvre HP, 2019, NUTRIENTS, V11, DOI 10.3390/nu11030666
   Feng YH, 2018, CELL PHYSIOL BIOCHEM, V49, P190, DOI 10.1159/000492853
   Filiou MD, 2019, TRENDS NEUROSCI, V42, P573, DOI 10.1016/j.tins.2019.07.002
   Fiorentino M, 2016, MOL AUTISM, V7, DOI 10.1186/s13229-016-0110-z
   Fisar Z, 2016, CURR ALZHEIMER RES, V13, P930, DOI 10.2174/1567205013666160314150856
   Frank MG, 2018, BRAIN BEHAV IMMUN, V69, P62, DOI 10.1016/j.bbi.2017.11.001
   Gao W, 2019, PSYCHOPHARMACOLOGY, V236, P1641, DOI 10.1007/s00213-018-5161-8
   García JJ, 2011, NEUROBIOL AGING, V32, P2045, DOI 10.1016/j.neurobiolaging.2009.12.013
   Garcia-Rizo C, 2016, PSYCHONEUROENDOCRINO, V67, P70, DOI 10.1016/j.psyneuen.2016.02.001
   Gardner A, 2003, J AFFECT DISORDERS, V76, P55, DOI 10.1016/S0165-0327(02)00067-8
   Gencer M, 2019, NEUROL SCI, V40, P1067, DOI 10.1007/s10072-019-3708-z
   Genedi M, 2019, CURR OPIN PSYCHIATR, V32, P185, DOI 10.1097/YCO.0000000000000499
   Geoffroy PA, 2019, ENCEPHALE, V45, P413, DOI 10.1016/j.encep.2019.04.068
   Grassme Heike, 2015, Neurosignals, V23, P84, DOI 10.1159/000442606
   Grosse L, 2016, PSYCHONEUROENDOCRINO, V73, P24, DOI 10.1016/j.psyneuen.2016.07.205
   Gu Y, 2019, FRONT MICROBIOL, V10, DOI 10.3389/fmicb.2019.01894
   Gulbins E, 2013, NAT MED, V19, P934, DOI 10.1038/nm.3214
   Hanyu H, 2019, ADV EXP MED BIOL, V1128, P147, DOI 10.1007/978-981-13-3540-2_8
   Hardeland R, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20051223
   Hroudová J, 2013, MITOCHONDRION, V13, P795, DOI 10.1016/j.mito.2013.05.005
   Hu SH, 2019, ADV SCI, V6, DOI 10.1002/advs.201900752
   Hu YM, 2018, ENVIRON TOXICOL PHAR, V64, P112, DOI 10.1016/j.etap.2018.09.002
   HUETHER G, 1993, EXPERIENTIA, V49, P665, DOI 10.1007/BF01923948
   Hussien R, 2011, PHYSIOL GENOMICS, V43, P255, DOI 10.1152/physiolgenomics.00177.2010
   Igudesman D, 2019, GASTROENTEROL CLIN N, V48, P343, DOI 10.1016/j.gtc.2019.04.003
   Iñarrea P, 2014, MOL NEUROBIOL, V49, P1, DOI 10.1007/s12035-013-8481-z
   Ji J, 2016, SCI REP-UK, V6, DOI 10.1038/srep24838
   Jiang GM, 2010, INT J BIOCHEM CELL B, V42, P1840, DOI 10.1016/j.biocel.2010.07.020
   Joshi AU, 2019, NAT NEUROSCI, V22, P1635, DOI 10.1038/s41593-019-0486-0
   Kanchanatawan B, 2018, MOL NEUROBIOL, V55, P1524, DOI 10.1007/s12035-017-0417-6
   Kanchanatawan B, 2017, METAB BRAIN DIS, V32, P1003, DOI 10.1007/s11011-017-9982-7
   Karasov WH, 2017, J EXP BIOL, V220, P2495, DOI 10.1242/jeb.144048
   Kim HN, 2018, BRAIN BEHAV IMMUN, V69, P374, DOI 10.1016/j.bbi.2017.12.012
   Kim Y, 2019, ANTIOXID REDOX SIGN, V31, P275, DOI 10.1089/ars.2018.7606
   Koeppen AH, 2016, ACTA NEUROPATHOL COM, V4, DOI 10.1186/s40478-016-0288-5
   Kogot-Levin A, 2014, BIOCHIMIE, V100, P88, DOI 10.1016/j.biochi.2013.07.027
   Kowalski K, 2019, J NEUROGASTROENTEROL, V25, P48, DOI 10.5056/jnm18087
   Lee JS, 2015, IMMUNITY, V43, P727, DOI 10.1016/j.immuni.2015.09.003
   Lee JS, 2015, CELL, V162, P1212, DOI 10.1016/j.cell.2015.08.054
   Lee Y, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/824120
   Li C, 2019, J CLIN PSYCHIAT, V80, DOI 10.4088/JCP.18m12422
   Li HY, 2019, J AGR FOOD CHEM, V67, P1889, DOI 10.1021/acs.jafc.8b06217
   Ling WM, 2019, EUR REV MED PHARMACO, V23, P2263, DOI 10.26355/eurrev_201903_17275
   Liu PS, 2018, MITOCHONDRION, V41, P45, DOI 10.1016/j.mito.2017.11.002
   Ma N, 2020, MED RES REV, V40, P606, DOI 10.1002/med.21628
   Maes M, 2008, NEUROENDOCRINOL LETT, V29, P287
   Maes M, 2008, NEUROENDOCRINOL LETT, V29, P117
   Maes M, 2019, CURR PHARM DESIGN, V25, P4405, DOI 10.2174/1381612825666191102165459
   Maes M, 2019, NITRIC OXIDE-BIOL CH, V91, P67, DOI 10.1016/j.niox.2019.07.003
   Maes M, 2019, NEUROTOX RES, V36, P306, DOI 10.1007/s12640-019-00054-6
   Maes M, 2019, MOL NEUROBIOL, V56, P7056, DOI 10.1007/s12035-019-1578-2
   Maes M, 2019, NEUROTOX RES, V35, P684, DOI 10.1007/s12640-018-9987-y
   Maldonado MD, 2012, PHYSIOL BEHAV, V105, P1099, DOI 10.1016/j.physbeh.2011.12.015
   Markus RP, 2007, NEUROIMMUNOMODULAT, V14, P126, DOI 10.1159/000110635
   Martin-Subero M, 2016, CNS SPECTRUMS, V21, P184, DOI 10.1017/S1092852915000449
   Maruani J, 2018, CHRONOBIOL INT, V35, P1335, DOI 10.1080/07420528.2018.1487975
   Mayo JC, 2017, J PINEAL RES, V62, DOI 10.1111/jpi.12373
   Messner MC, 2010, ADV EXP MED BIOL, V688, P156
   Milanova IV, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00424
   Mills EL, 2016, EUR J IMMUNOL, V46, P13, DOI 10.1002/eji.201445427
   Milosevic I, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20020395
   Misiak B, 2019, NEUROSCI BIOBEHAV R, V102, P362, DOI 10.1016/j.neubiorev.2019.05.018
   Morris G, 2017, MOL NEUROBIOL, V54, P4271, DOI 10.1007/s12035-016-9975-2
   Morris G, 2013, MOL NEUROBIOL, V48, P883, DOI 10.1007/s12035-013-8477-8
   Muhomah TA, 2019, BIOSCI MICROB FOOD H, V38, P55, DOI 10.12938/bmfh.18-027
   Muneer Ather, 2019, Chonnam Med J, V55, P8, DOI 10.4068/cmj.2019.55.1.8
   Muxel SM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0052010
   Naia L, 2017, J NEUROSCI, V37, P2776, DOI 10.1523/JNEUROSCI.2006-14.2016
   Nakamura S, 2018, J ANIM SCI, V96, P4902, DOI 10.1093/jas/sky334
   Namgaladze D, 2019, CELLS-BASEL, V8, DOI 10.3390/cells8091088
   Nijland PG, 2014, GLIA, V62, P1125, DOI 10.1002/glia.22667
   Nogueira TC, 2011, ENDOCRINOLOGY, V152, P1253, DOI 10.1210/en.2010-1088
   Ottesen NM, 2020, PSYCHOL MED, V50, P1736, DOI 10.1017/S003329171900182X
   Park J, 2015, NEUROSCI LETT, V584, P191, DOI 10.1016/j.neulet.2014.10.016
   Park SJ, 2017, CELL REP, V21, P2748, DOI 10.1016/j.celrep.2017.11.043
   de Melo LGP, 2017, PROG NEURO-PSYCHOPH, V78, P34, DOI 10.1016/j.pnpbp.2017.04.027
   Pollak DD, 2020, SEMIN CELL DEV BIOL, V97, P181, DOI 10.1016/j.semcdb.2019.06.006
   Pontes GN, 2007, J PINEAL RES, V43, P365, DOI 10.1111/j.1600-079X.2007.00487.x
   Rajani C, 2018, CLIN SCI, V132, P791, DOI 10.1042/CS20171328
   Rea Kieran, 2017, Mod Trends Pharmacopsychiatry, V31, P152, DOI 10.1159/000470813
   Ren C, 2018, INT J BIOL SCI, V14, P748, DOI 10.7150/ijbs.24576
   Rezin GT, 2009, NEUROCHEM RES, V34, P1021, DOI 10.1007/s11064-008-9865-8
   Roberts RC, 2017, SCHIZOPHR RES, V187, P17, DOI 10.1016/j.schres.2017.01.056
   Rodriguez M, 2016, CURR PHARM DESIGN, V22, P6134, DOI 10.2174/1381612822666160915160520
   Rose S, 2018, TRANSL PSYCHIAT, V8, DOI 10.1038/s41398-017-0089-z
   Samczuk P, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19123744
   Scheinost D, 2016, NEUROIMAGE-CLIN, V12, P381, DOI 10.1016/j.nicl.2016.08.010
   Schulthess J, 2019, IMMUNITY, V50, P432, DOI 10.1016/j.immuni.2018.12.018
   Schwarz E, 2008, J PROTEOME RES, V7, P4266, DOI 10.1021/pr800188y
   Scott KA, 2017, PHYSIOL BEHAV, V178, P117, DOI 10.1016/j.physbeh.2017.03.006
   Seo M, 2019, CURR PHARM DESIGN, V25, P4344, DOI 10.2174/1381612825666191105102545
   Sharma S, 2019, CURR NEUROPHARMACOL, V17, P550, DOI 10.2174/1570159X16666180302120322
   Sharma S, 2019, GENOME BIOL, V20, DOI 10.1186/s13059-019-1651-1
   Shepard JD, 2003, BRAIN RES, V963, P203, DOI 10.1016/S0006-8993(02)03978-1
   Sicras-Mainar A, 2017, BMC NEUROL, V17, DOI 10.1186/s12883-017-0914-2
   Simeonova D, 2018, CURR TOP MED CHEM, V18, P1641, DOI 10.2174/1568026618666181115100610
   Slyepchenko A, 2016, CURR PHARM DESIGN, V22, P6087, DOI 10.2174/1381612822666160922165706
   Slyepchenko A, 2016, NEUROSCI BIOBEHAV R, V64, P83, DOI 10.1016/j.neubiorev.2016.02.002
   Sommansson A, 2013, J PINEAL RES, V54, P282, DOI 10.1111/jpi.12013
   Steardo L, 2019, J AFFECT DISORDERS, V245, P174, DOI 10.1016/j.jad.2018.10.360
   Stevens BR, 2018, GUT, V67, P1555, DOI 10.1136/gutjnl-2017-314759
   Tan DX, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17122124
   Tan Z, 2015, J BIOL CHEM, V290, P46, DOI 10.1074/jbc.M114.603589
   Tapia-Rojas C, 2017, BIRTH DEFECTS RES, V109, P1623, DOI 10.1002/bdr2.1172
   Tian L, 2017, FISH SHELLFISH IMMUN, V66, P548, DOI 10.1016/j.fsi.2017.05.049
   Tse JKY, 2017, ACS CHEM NEUROSCI, V8, P1438, DOI 10.1021/acschemneuro.7b00176
   Tsuchimine S, 2019, NEUROPSYCH DIS TREAT, V15, P2221, DOI 10.2147/NDT.S209023
   Tur J, 2017, ADV IMMUNOL, V133, P1, DOI 10.1016/bs.ai.2016.12.001
   Vanuytsel T, 2014, GUT, V63, P1293, DOI 10.1136/gutjnl-2013-305690
   Victor VM, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0106463
   Wu TH, 2014, J STEROID BIOCHEM, V144, P253, DOI 10.1016/j.jsbmb.2014.07.008
   Xing XG, 2016, J PHYSIOL BIOCHEM, V73, P405, DOI 10.1007/s13105-017-0568-y
   Xu RH, 2020, BRAIN BEHAV IMMUN, V85, P120, DOI 10.1016/j.bbi.2019.06.039
   Yamane M, 2007, ARCH BIOCHEM BIOPHYS, V459, P159, DOI 10.1016/j.abb.2007.01.008
   Yang BB, 2019, GEN PSYCHIAT, V32, DOI 10.1136/gpsych-2019-100056
   Yang T, 2018, PHYSIOL REP, V6, DOI 10.14814/phy2.13732
   Yu M, 2019, BRAIN BEHAV IMMUN, V82, P167, DOI 10.1016/j.bbi.2019.08.007
   Zhang HY, 2016, J NUTR BIOCHEM, V27, P299, DOI 10.1016/j.jnutbio.2015.09.020
   Zhou LL, 2010, MEDIAT INFLAMM, V2010, DOI 10.1155/2010/951210
   Zucchi FCR, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0056967
NR 170
TC 88
Z9 88
U1 0
U2 18
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1568-0266
EI 1873-5294
J9 CURR TOP MED CHEM
JI Curr. Top. Med. Chem.
PY 2020
VL 20
IS 7
BP 524
EP 539
DI 10.2174/1568026620666200131094445
PG 16
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy
GA LG7NU
UT WOS:000528283700004
PM 32003689
DA 2025-06-11
ER

PT J
AU Caruso, A
   Nicoletti, F
   Gaetano, A
   Scaccianoce, S
AF Caruso, Alessandra
   Nicoletti, Ferdinando
   Gaetano, Alessandra
   Scaccianoce, Sergio
TI Risk Factors for Alzheimer's Disease: Focus on Stress
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE stress; glucocorticoids; Alzheimer's disease; risk factor; animal model
ID EARLY-LIFE STRESS; AMYLOID-BETA; GLUCOCORTICOID-RECEPTOR; SYNAPTIC
   DYSFUNCTION; TAU-PROTEIN; HYPERPHOSPHORYLATED-TAU; MISSENSE MUTATIONS;
   COGNITIVE FUNCTION; MOUSE MODEL; BRAIN
AB In vulnerable individuals, chronic and persistent stress is an established risk factor for disorders that are comorbid with Alzheimer's disease (AD), such as hypertension, obesity and metabolic syndrome, and psychiatric disorders. There are no disease-modifying drugs in the treatment of AD, and all phase-3 clinical trials with anti-amyloid drugs (e.g., beta- or gamma-secretase inhibitors and monoclonal antibodies) did not meet the primary endpoints. There are many reasons for the lack of efficacy of anti-amyloid drugs in AD, the most likely being a late start of treatment, considering that pathophysiological mechanisms underlying synaptic dysfunction and neuronal death begin several decades before the clinical onset of AD. The identification of risk factors is, therefore, an essential step for early treatment of AD with candidate disease-modifying drugs. Preclinical studies suggest that stress, and the resulting activation of the hypothalamic-pituitary-adrenal axis, can induce biochemical abnormalities reminiscent to those found in autoptic brain samples from individuals affected by AD (e.g., increases amyloid precursor protein and tau hyperphosphorylation). In this review, we will critically analyze the current knowledge supporting stress as a potential risk factor for AD.
C1 [Caruso, Alessandra; Nicoletti, Ferdinando; Gaetano, Alessandra; Scaccianoce, Sergio] Sapienza Univ Roma, Dept Physiol & Pharmacol, Rome, Italy.
   [Nicoletti, Ferdinando] IRCCS Neuromed, Neuropharmacol Res Unit, Pozzilli, Italy.
C3 Sapienza University Rome; IRCCS Neuromed
RP Scaccianoce, S (corresponding author), Sapienza Univ Roma, Dept Physiol & Pharmacol, Rome, Italy.
EM sergio.scaccianoce@uniroma1.it
RI Nicoletti, Ferdinando/M-4428-2016
CR Aisen PS, 2000, NEUROLOGY, V54, P588, DOI 10.1212/WNL.54.3.588
   Anand A, 2017, EUR J PHARMACOL, V815, P364, DOI 10.1016/j.ejphar.2017.09.043
   Angelucci L, 2000, EUR J PHARMACOL, V405, P139, DOI 10.1016/S0014-2999(00)00547-1
   Barnard ND, 2014, NEUROBIOL AGING, V35, pS74, DOI 10.1016/j.neurobiolaging.2014.03.033
   Barnes DE, 2012, ARCH GEN PSYCHIAT, V69, P493, DOI 10.1001/archgenpsychiatry.2011.1481
   Belanoff JK, 2002, J MOL NEUROSCI, V19, P201, DOI 10.1007/s12031-002-0033-3
   Berg MT, 2017, SOC SCI MED, V193, P130, DOI 10.1016/j.socscimed.2017.09.028
   Bird T.D., 1999, EARLY ONSET FAMILIAL
   BRUNO G, 1995, ALZ DIS ASSOC DIS, V9, P128
   Budas G, 1999, NEUROSCI LETT, V276, P61, DOI 10.1016/S0304-3940(99)00790-9
   Campbell SN, 2015, J ALZHEIMERS DIS, V45, P1175, DOI 10.3233/JAD-142844
   Cañete T, 2015, BEHAV BRAIN RES, V281, P156, DOI 10.1016/j.bbr.2014.11.004
   Chen YC, 2016, NEUROPSYCHOPHARMACOL, V41, P197, DOI 10.1038/npp.2015.181
   Crimins JL, 2013, AGEING RES REV, V12, P757, DOI 10.1016/j.arr.2013.03.002
   Curto M, 2017, ALZ DIS ASSOC DIS, V31, P173, DOI 10.1097/WAD.0000000000000156
   de Oliveira FF, 2018, CURR ALZHEIMER RES, V15, P386, DOI 10.2174/1567205014666171016101816
   de Oliveira FF, 2014, J ALZHEIMERS DIS, V42, pS321, DOI 10.3233/JAD-132189
   de Quervain DJF, 2004, HUM MOL GENET, V13, P47, DOI 10.1093/hmg/ddg361
   DeBattista Charles, 2005, Current Alzheimer Research, V2, P125
   Dich N, 2015, ANXIETY STRESS COPIN, V28, P372, DOI 10.1080/10615806.2014.969720
   Egan MF, 2018, NEW ENGL J MED, V378, P1691, DOI 10.1056/NEJMoa1706441
   ELLIOTT EM, 1993, J NEUROCHEM, V61, P57, DOI 10.1111/j.1471-4159.1993.tb03537.x
   Fitzpatrick AWP, 2017, NATURE, V547, P185, DOI 10.1038/nature23002
   Goate A, 2006, ALZHEIMER'S DISEASE: A CENTURY OF SCIENTIFIC AND CLINICAL RESEARCH, P341
   Götz J, 2018, NAT REV NEUROSCI, V19, P583, DOI 10.1038/s41583-018-0054-8
   GomezIsla T, 1996, J NEUROSCI, V16, P4491
   Green KN, 2006, J NEUROSCI, V26, P9047, DOI 10.1523/JNEUROSCI.2797-06.2006
   GREENWALD BS, 1986, AM J PSYCHIAT, V143, P442
   Guerreiro RJ, 2012, NEUROBIOL AGING, V33, P437, DOI 10.1016/j.neurobiolaging.2010.03.025
   Hampel H, 2015, EXPERT REV NEUROTHER, V15, P83, DOI 10.1586/14737175.2015.995637
   Han F, 2005, NEUROSCI RES, V51, P371, DOI 10.1016/j.neures.2004.12.013
   HATZINGER M, 1995, NEUROBIOL AGING, V16, P205, DOI 10.1016/0197-4580(94)00159-6
   Henneman WJP, 2009, NEUROLOGY, V72, P999, DOI 10.1212/01.wnl.0000344568.09360.31
   Hollands C, 2016, FRONT NEUROSCI-SWITZ, V10, DOI 10.3389/fnins.2016.00178
   Holtzman DM, 2011, SCI TRANSL MED, V3, DOI 10.1126/scitranslmed.3002369
   Hoogendijk WJG, 2006, NEUROBIOL AGING, V27, DOI 10.1016/j.neurobiolaging.2005.07.017
   Hoover BR, 2010, NEURON, V68, P1067, DOI 10.1016/j.neuron.2010.11.030
   Huang Q, 2014, PLOS ONE, V9
   Iqbal K, 2010, CURR ALZHEIMER RES, V7, P656, DOI 10.2174/156720510793611592
   Ittner LM, 2010, CELL, V142, P387, DOI 10.1016/j.cell.2010.06.036
   Jeong YH, 2006, FASEB J, V20, P729, DOI 10.1096/fj.05-4265fje
   Johansson L, 2010, BRAIN, V133, P2217, DOI 10.1093/brain/awq116
   Kimura T, 2007, EMBO J, V26, P5143, DOI 10.1038/sj.emboj.7601917
   Kvetnansky R, 2016, STRESS, V19, P395, DOI 10.1080/10253890.2016.1183119
   Le MH, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0147250
   Lee KW, 2009, J NEUROCHEM, V108, P165, DOI 10.1111/j.1471-4159.2008.05769.x
   Lesuis SL, 2019, NEUROPHARMACOLOGY, V150, P175, DOI 10.1016/j.neuropharm.2019.02.023
   Lesuis SL, 2018, ALZHEIMERS RES THER, V10, DOI 10.1186/s13195-018-0422-7
   Lesuis SL, 2017, NEUROBIOL LEARN MEM, V144, P27, DOI 10.1016/j.nlm.2017.05.016
   Lesuis SL, 2016, ONCOTARGET, V7, P39118, DOI 10.18632/oncotarget.9776
   LEVYLAHAD E, 1995, SCIENCE, V269, P973, DOI 10.1126/science.7638622
   Loi M, 2017, NEUROSCIENCE, V342, P101, DOI 10.1016/j.neuroscience.2015.08.024
   Lopes S, 2016, P NATL ACAD SCI USA, V113, pE3755, DOI 10.1073/pnas.1600953113
   Martisova E, 2013, CURR ALZHEIMER RES, V10, P420, DOI 10.2174/1567205011310040007
   Meaney MJ, 2001, ANNU REV NEUROSCI, V24, P1161, DOI 10.1146/annurev.neuro.24.1.1161
   Mu YL, 2011, MOL NEURODEGENER, V6, DOI 10.1186/1750-1326-6-85
   Murray Cynelle, 2006, Am J Alzheimers Dis Other Demen, V21, P37, DOI 10.1177/153331750602100111
   Naninck EFG, 2015, HIPPOCAMPUS, V25, P309, DOI 10.1002/hipo.22374
   Nichols MR, 2019, J NEUROCHEM, V149, P562, DOI 10.1111/jnc.14674
   Nisticò R, 2012, MOL NEUROBIOL, V46, P572, DOI 10.1007/s12035-012-8324-3
   Ouanes S, 2019, FRONT AGING NEUROSCI, V11, DOI 10.3389/fnagi.2019.00043
   Ownby RL, 2006, ARCH GEN PSYCHIAT, V63, P530, DOI 10.1001/archpsyc.63.5.530
   Peskind ER, 2001, NEUROLOGY, V56, P1094, DOI 10.1212/WNL.56.8.1094
   Pinheiro S, 2016, MOL NEUROBIOL, V53, P4745, DOI 10.1007/s12035-015-9356-2
   Pomara N, 2002, NEUROLOGY, V58, P1436, DOI 10.1212/WNL.58.9.1436
   Rasmuson S, 2001, BIOL PSYCHIAT, V49, P547, DOI 10.1016/S0006-3223(00)01015-5
   Rissman RA, 2007, J NEUROSCI, V27, P6552, DOI 10.1523/JNEUROSCI.5173-06.2007
   Rissman RA, 2012, P NATL ACAD SCI USA, V109, P6277, DOI 10.1073/pnas.1203140109
   ROGAEV EI, 1995, NATURE, V376, P775, DOI 10.1038/376775a0
   ROHER AE, 1994, BIOCHEM BIOPH RES CO, V205, P1755, DOI 10.1006/bbrc.1994.2872
   Rojas-Gutierrez E, 2017, SYNAPSE, V71, DOI 10.1002/syn.21990
   Russcher H, 2005, MOL ENDOCRINOL, V19, P1687, DOI 10.1210/me.2004-0467
   Saydak S J, 1987, J Nurs Staff Dev, V3, P164
   Selkoe DJ, 2016, EMBO MOL MED, V8, P595, DOI 10.15252/emmm.201606210
   Sevigny J, 2016, NATURE, V537, P50, DOI 10.1038/nature19323
   SHERRINGTON R, 1995, NATURE, V375, P754, DOI 10.1038/375754a0
   Shree S., 2017, ANIMAL MODELS NEUROL, DOI [10.1007/978-981-10-5981-0_2, DOI 10.1007/978-981-10-5981-0_2]
   Sierksma ASR, 2013, NEUROBIOL AGING, V34, P319, DOI 10.1016/j.neurobiolaging.2012.05.012
   Singh-Manoux A, 2017, JAMA PSYCHIAT, V74, P712, DOI 10.1001/jamapsychiatry.2017.0660
   Sotiropoulos I, 2008, J NEUROCHEM, V107, P385, DOI 10.1111/j.1471-4159.2008.05613.x
   Sotiropoulos I, 2011, J NEUROSCI, V31, P7840, DOI 10.1523/JNEUROSCI.0730-11.2011
   Tai HC, 2012, AM J PATHOL, V181, P1426, DOI 10.1016/j.ajpath.2012.06.033
   van Rossum EFC, 2008, NEUROBIOL AGING, V29, P716, DOI 10.1016/j.neurobiolaging.2006.11.016
   Wilson RS, 2003, NEUROLOGY, V61, P1479, DOI 10.1212/01.WNL.0000096167.56734.59
   Xie M, 2017, J MOL NEUROSCI, V62, P154, DOI 10.1007/s12031-017-0919-8
   Xu W, 2015, J NEUROL NEUROSUR PS, V86, P1299, DOI 10.1136/jnnp-2015-310548
   Yin KJ, 2006, J NEUROSCI, V26, P10939, DOI 10.1523/JNEUROSCI.2085-06.2006
   Zempel H, 2013, EMBO J, V32, P2920, DOI 10.1038/emboj.2013.207
NR 88
TC 20
Z9 20
U1 4
U2 26
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD SEP 10
PY 2019
VL 10
AR 976
DI 10.3389/fphar.2019.00976
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy
GA IW7JT
UT WOS:000485165700002
PM 31551781
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Iwasaki, Y
   Suganami, T
   Hachiya, R
   Shirakawa, I
   Kim-Saijo, M
   Tanaka, M
   Hamaguchi, M
   Takai-Igarashi, T
   Nakai, M
   Miyamoto, Y
   Ogawa, Y
AF Iwasaki, Yorihiro
   Suganami, Takayoshi
   Hachiya, Rumi
   Shirakawa, Ibuki
   Kim-Saijo, Misa
   Tanaka, Miyako
   Hamaguchi, Miho
   Takai-Igarashi, Takako
   Nakai, Michikazu
   Miyamoto, Yoshihiro
   Ogawa, Yoshihiro
TI Activating Transcription Factor 4 Links Metabolic Stress to
   Interleukin-6 Expression in Macrophages
SO DIABETES
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; NF-KAPPA-B;
   INTERACTION NETWORKS; INFLAMMATORY CHANGES; INSULIN-RESISTANCE;
   FATTY-ACIDS; MOUSE MODEL; ER STRESS; HOMEOSTASIS
AB Chronic inflammation is a molecular element of the metabolic syndrome and type 2 diabetes. Saturated fatty acids (SFAs) are considered to be an important proinflammatory factor. However, it is still incompletely understood how SFAs induce proinflammatory cytokine expression. Hereby we report that activating transcription factor (ATF) 4, a transcription factor that is induced downstream of metabolic stresses including endoplasmic reticulum (ER) stress, plays critical roles in SFA-induced interleukin-6 (Il6) expression. DNA microarray analysis using primary macrophages revealed that the ATF4 pathway is activated by SFAs. Haploinsufficiency and short hairpin RNA-based knockdown of ATF4 in macrophages markedly inhibited SFA- and metabolic stress-induced Il6 expression. Conversely, pharmacological activation of the ATF4 pathway and overexpression of ATF4 resulted in enhanced Il6 expression. Moreover, ATF4 acts in synergy with the Toll-like receptor-4 signaling pathway, which is known to be activated by SFAs. At a molecular level, we found that ATF4 exerts its proinflammatory effects through at least two different mechanisms: ATF4 is involved in SFA-induced nuclear factor-B activation; and ATF4 directly activates the Il6 promoter. These findings provide evidence suggesting that ATF4 links metabolic stress and Il6 expression in macrophages.
C1 [Iwasaki, Yorihiro; Hachiya, Rumi; Kim-Saijo, Misa; Tanaka, Miyako; Hamaguchi, Miho; Ogawa, Yoshihiro] Tokyo Med & Dent Univ, Dept Mol Endocrinol & Metab, Grad Sch Med & Dent Sci, Tokyo, Japan.
   [Suganami, Takayoshi; Shirakawa, Ibuki] Tokyo Med & Dent Univ, Dept Organ Network & Metab, Grad Sch Med & Dent Sci, Tokyo, Japan.
   [Ogawa, Yoshihiro] Tokyo Med & Dent Univ, Global Ctr Excellence Program, Int Res Ctr Mol Sci Tooth & Bone Dis, Tokyo, Japan.
   [Iwasaki, Yorihiro] Tazuke Kofukai Med Res Inst, Ctr Diabet & Endocrinol, Osaka, Japan.
   [Takai-Igarashi, Takako] Tohoku Univ, Dept Hlth Record Informat, Tohoku Med Megabank Org, Sendai, Miyagi 980, Japan.
   [Nakai, Michikazu; Miyamoto, Yoshihiro] Natl Cerebral & Cardiovasc Ctr, Dept Prevent Med & Epidemiol Informat, Osaka, Japan.
   [Miyamoto, Yoshihiro] Natl Cerebral & Cardiovasc Ctr, Dept Prevent Cardiol, Osaka, Japan.
   [Suganami, Takayoshi] Japan Sci & Technol Agcy, Precursory Res Embryon Sci & Technol, Tokyo 1028666, Japan.
   [Hachiya, Rumi] Japan Soc Promot Sci Young Sci, Tokyo, Japan.
C3 Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU);
   Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU);
   Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU);
   Tohoku University; National Cerebral & Cardiovascular Center - Japan;
   National Cerebral & Cardiovascular Center - Japan; Japan Science &
   Technology Agency (JST); Japan Society for the Promotion of Science
RP Suganami, T (corresponding author), Tokyo Med & Dent Univ, Dept Organ Network & Metab, Grad Sch Med & Dent Sci, Tokyo, Japan.
EM suganami.mem@tmd.ac.jp; ogawa.mem@tmd.ac.jp
RI Hachiya, Rumi/ABF-5457-2021; Iwasaki, Yorihiro/HJI-2969-2023; SUGANAMI,
   Takayoshi/A-9475-2016; Nakai, Michikazu/ADJ-0980-2022; Tanaka,
   Miyako/B-2805-2016
OI Suganami, Takayoshi/0000-0002-1918-0465; xing zhi, shi
   zhi/0000-0003-3289-5681; Hachiya, Rumi/0000-0001-8412-3494; Ogawa,
   Yoshihiro/0000-0002-0834-2836; Iwasaki, Yorihiro/0000-0001-9787-7922
FU Ministry of Education, Culture, Sports, Science and Technology of Japan;
   Japan Science and Technology Agency, Precursory Research for Embryonic
   Science and Technology; Astellas Foundation for Research on Metabolic
   Disorders; Nestle Nutrition Council, Japan; Grants-in-Aid for Scientific
   Research [25670407, 24790942, 21117007] Funding Source: KAKEN
FX This work was supported in part by Grants-in-Aid for Scientific Research
   from the Ministry of Education, Culture, Sports, Science and Technology
   of Japan; Japan Science and Technology Agency, Precursory Research for
   Embryonic Science and Technology; Astellas Foundation for Research on
   Metabolic Disorders; and Nestle Nutrition Council, Japan.
CR Ariyama H, 2010, J BIOL CHEM, V285, P22027, DOI 10.1074/jbc.M110.126870
   Bergholdt R, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0006250
   Boyce M, 2005, SCIENCE, V307, P935, DOI 10.1126/science.1101902
   Dahl JA, 2008, NAT PROTOC, V3, P1032, DOI 10.1038/nprot.2008.68
   Erbay E, 2009, NAT MED, V15, P1383, DOI 10.1038/nm.2067
   Fu SN, 2011, NATURE, V473, P528, DOI 10.1038/nature09968
   Harding HP, 2003, MOL CELL, V11, P619, DOI 10.1016/S1097-2765(03)00105-9
   Hayden MS, 2008, CELL, V132, P344, DOI 10.1016/j.cell.2008.01.020
   Holland WL, 2011, J CLIN INVEST, V121, P1858, DOI 10.1172/JCI43378
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   Ichioka M, 2011, DIABETES, V60, P819, DOI 10.2337/db10-0864
   Ishiyama J, 2011, J LIPID RES, V52, P299, DOI [10.1194/jlr.M007104, 10.1194/jlr.m007104]
   Itoh M, 2011, AM J PATHOL, V179, P2454, DOI 10.1016/j.ajpath.2011.07.014
   Jiang HY, 2003, MOL CELL BIOL, V23, P5651, DOI 10.1128/MCB.23.16.5651-5663.2003
   Joshi-Tope G, 2005, NUCLEIC ACIDS RES, V33, pD428, DOI 10.1093/nar/gki072
   Krogan NJ, 2006, NATURE, V440, P637, DOI 10.1038/nature04670
   Lee JY, 2001, J BIOL CHEM, V276, P16683, DOI 10.1074/jbc.M011695200
   LIN YS, 1988, P NATL ACAD SCI USA, V85, P3396, DOI 10.1073/pnas.85.10.3396
   Martinon F, 2010, NAT IMMUNOL, V11, P411, DOI 10.1038/ni.1857
   Mason P, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0033823
   Nakamura T, 2010, CELL, V140, P338, DOI 10.1016/j.cell.2010.01.001
   Odegaard JI, 2013, SCIENCE, V339, P172, DOI 10.1126/science.1230721
   Özcan U, 2006, SCIENCE, V313, P1137, DOI 10.1126/science.1128294
   Ohoka N, 2005, EMBO J, V24, P1243, DOI 10.1038/sj.emboj.7600596
   Osborn O, 2012, NAT MED, V18, P363, DOI 10.1038/nm.2627
   Shannon P, 2003, GENOME RES, V13, P2498, DOI 10.1101/gr.1239303
   Shi H, 2006, J CLIN INVEST, V116, P3015, DOI 10.1172/JCI28898
   Suganami T, 2005, ARTERIOSCL THROM VAS, V25, P2062, DOI 10.1161/01.ATV.0000183883.72263.13
   Suganami T, 2007, ARTERIOSCL THROM VAS, V27, P84, DOI 10.1161/01.ATV.0000251608.09329.9a
   Suganami T, 2009, CIRC RES, V105, P25, DOI 10.1161/CIRCRESAHA.109.196261
   Szklarczyk D, 2011, NUCLEIC ACIDS RES, V39, pD561, DOI 10.1093/nar/gkq973
   Tanaka T, 1998, GENES CELLS, V3, P801, DOI 10.1046/j.1365-2443.1998.00230.x
   Tian Q, 2009, HYPERTENSION, V53, P798, DOI 10.1161/HYPERTENSIONAHA.108.126656
   Vattem KM, 2004, P NATL ACAD SCI USA, V101, P11269, DOI 10.1073/pnas.0400541101
   Volmer R, 2013, P NATL ACAD SCI USA, V110, P4628, DOI 10.1073/pnas.1217611110
   Woo CW, 2009, NAT CELL BIOL, V11, P1473, DOI 10.1038/ncb1996
NR 36
TC 101
Z9 107
U1 1
U2 13
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD JAN
PY 2014
VL 63
IS 1
BP 152
EP 161
DI 10.2337/db13-0757
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 275MF
UT WOS:000328680400023
PM 23990363
OA hybrid
DA 2025-06-11
ER

PT J
AU Rajagopalan, K
   Meyer, K
   O'Day, K
   Denno, M
   Loebel, A
AF Rajagopalan, Krithika
   Meyer, Kellie
   O'Day, Ken
   Denno, Melissa
   Loebel, Antony
TI Cost-effectiveness of lurasidone vs quetiapine extended-release (XR) in
   patients with bipolar depression
SO JOURNAL OF MEDICAL ECONOMICS
LA English
DT Article
DE Cost-effectiveness; Lurasidone; Bipolar I depression; Quetiapine XR
ID WEEKLY SYMPTOMATIC STATUS; MAINTENANCE TREATMENT; METABOLIC SYNDROME;
   MOOD STABILIZERS; NATURAL-HISTORY; DISORDER; HEALTH; PREVALENCE;
   LIFETIME; BURDEN
AB Objective:
   Bipolar disorder imposes a high economic burden on patients and society. Lurasidone and quetiapine extended-release (XR) are atypical antipsychotic agents indicated for monotherapy treatment of bipolar depression. Lurasidone is also indicated as adjunctive therapy with lithium or valproate for depressive episodes associated with bipolar disorder. The objective of this analysis was to estimate the cost-effectiveness of lurasidone and quetiapine XR in patients with bipolar depression.
   Methods:
   A cost-effectiveness model was developed to compare lurasidone to quetiapine XR. The model was based on a US third-party payer perspective over a 3-month time horizon. The effectiveness measure in the model was the percentage of patients achieving remission (Montgomery-Asberg Depression Rating Scale [MADRS] total score <= 12 by weeks 6-8). The comparison of remission rates was made through an adjusted indirect treatment comparison of lurasidone and quetiapine XR pivotal trials using placebo as the common comparator. Resource utilization for remission vs no remission was estimated from published expert panel data, and resource costs were obtained from a retrospective database study of bipolar I depression patients. Drug costs were estimated using the mean dose from clinical trials and wholesale acquisition costs.
   Results:
   Over the 3-month model time period, lurasidone and quetiapine XR patients, respectively, had similar mean numbers of emergency department visits (0.48 vs 0.50), inpatient days (2.1 vs 2.2), and office visits (9.3 vs 9.6). More lurasidone than quetiapine XR patients achieved remission (52.0% vs 43.2%) with slightly higher total costs ($4982 vs $4676), resulting in an incremental cost-effectiveness ratio of $3474 per remission. The probabilistic sensitivity analysis showed lurasidone had an 86% probability of being cost-effective compared to quetiapine XR at a willingness-to-pay threshold of $10,000 per remission.
   Conclusions:
   Lurasidone may be a cost-effective option when compared to quetiapine XR for the treatment of adults with bipolar depression.
C1 [Rajagopalan, Krithika; Loebel, Antony] Sunovion Pharmaceut Inc, Marlborough, MA USA.
   [Meyer, Kellie; O'Day, Ken; Denno, Melissa] Xcenda LLC, Palm Harbor, FL USA.
C3 Dainippon Sumitomo Pharmaceutical Company; Sunovion Pharmaceuticals
   Inc.; AmerisourceBergen Corporation; Xcenda, LLC
RP Rajagopalan, K (corresponding author), Sunovion Pharmaceut Inc, Marlborough, MA USA.
EM Krithika.Rajagopalan@sunovion.com
OI Rajagopalan, Krithika/0000-0002-4878-0822
FU Sunovion Pharmaceuticals Inc.
FX This manuscript was sponsored by Sunovion Pharmaceuticals Inc.
CR Altshuler LL, 2002, J CLIN PSYCHIAT, V63, P807, DOI 10.4088/JCP.v63n0910
   [Anonymous], 2013, LAT PACK INS
   [Anonymous], RED BOOK ONL
   [Anonymous], 2013, SER XR PACK INS
   [Anonymous], 2013, TRUV HLTH MARKETSCAN
   [Anonymous], 2011, NAT REG EST HOSP US
   Begley CE, 2001, PHARMACOECONOMICS, V19, P483, DOI 10.2165/00019053-200119050-00004
   Dilsaver SC, 2011, J AFFECT DISORDERS, V129, P79, DOI 10.1016/j.jad.2010.08.030
   Ekman M, 2012, PHARMACOECONOMICS, V30, P513, DOI 10.2165/11594930-000000000-00000
   Fagiolini A, 2005, BIPOLAR DISORD, V7, P424, DOI 10.1111/j.1399-5618.2005.00234.x
   Fajutrao L, 2009, CLIN THER, V31, P1456, DOI 10.1016/j.clinthera.2009.06.009
   Fleurence Rachael L, 2007, Prim Care Companion J Clin Psychiatry, V9, P419
   Fu AZ, 2004, AM PSYCH ASS 157 ANN
   Gardner HH, 2006, J CLIN PSYCHIAT, V67, P1209, DOI 10.4088/JCP.v67n0806
   Goetzel RZ, 2003, J OCCUP ENVIRON MED, V45, P5, DOI 10.1097/00043764-200301000-00007
   Huxley N, 2007, BIPOLAR DISORD, V9, P183, DOI 10.1111/j.1399-5618.2007.00430.x
   Judd LL, 2002, ARCH GEN PSYCHIAT, V59, P530, DOI 10.1001/archpsyc.59.6.530
   Judd LL, 2003, ARCH GEN PSYCHIAT, V60, P261, DOI 10.1001/archpsyc.60.3.261
   Kleinman LS, 2003, PHARMACOECONOMICS, V21, P601, DOI 10.2165/00019053-200321090-00001
   Kupka RW, 2007, BIPOLAR DISORD, V9, P531, DOI 10.1111/j.1399-5618.2007.00467.x
   Leclerc E, 2013, J AFFECT DISORDERS, V149, P247, DOI 10.1016/j.jad.2013.01.036
   Loebel A, 2014, AM J PSYCHIAT, V171, P160, DOI 10.1176/appi.ajp.2013.13070984
   McIntyre RS, 2006, CLIN THER, V28, P1882, DOI 10.1016/j.clinthera.2006.11.007
   Merikangas KR, 2007, ARCH GEN PSYCHIAT, V64, P543, DOI 10.1001/archpsyc.64.5.543
   National Institute of Mental Health, 2012, BIPOLAR DISORDER
   Perlick DA, 1999, PSYCHIAT SERV, V50, P806, DOI 10.1176/ps.50.6.806
   Plosker GL, 2012, PHARMACOECONOMICS, V30, P611, DOI 10.2165/11208500-000000000-00000
   SIMON G, 1995, AM J PSYCHIAT, V152, P352
   Suppes T, 2010, J AFFECT DISORDERS, V121, P106, DOI 10.1016/j.jad.2009.10.007
   Unutzer J, 1997, JAMA, V277, P1618, DOI 10.1001/jama.277.20.1618
   Vancampfort D, 2013, AM J PSYCHIAT, V170, P265, DOI 10.1176/appi.ajp.2012.12050620
   Woodward TC, 2010, PHARMACOECONOMICS, V28, P751, DOI 10.2165/11538350-000000000-00000
   Woodward Tatia Chay, 2009, J Med Econ, V12, P259, DOI 10.3111/13696990903266612
NR 33
TC 5
Z9 5
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1369-6998
EI 1941-837X
J9 J MED ECON
JI J. Med. Econ.
PY 2015
VL 18
IS 10
BP 821
EP 827
DI 10.3111/13696998.2015.1052462
PG 7
WC Economics; Health Care Sciences & Services; Health Policy & Services;
   Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Business & Economics; Health Care Sciences & Services; General &
   Internal Medicine
GA DD5OL
UT WOS:000369973500007
PM 25985265
DA 2025-06-11
ER

PT J
AU Lu, HJ
   Koju, N
   Sheng, R
AF Lu, Hao-jun
   Koju, Nirmala
   Sheng, Rui
TI Mammalian integrated stress responses in stressed organelles and their
   functions
SO ACTA PHARMACOLOGICA SINICA
LA English
DT Review
DE integrated stress response; organelles; eukaryotic translation
   initiation factor 2; activating transcription factor 4; protein
   homeostasis
ID UNFOLDED-PROTEIN-RESPONSE; ENDOPLASMIC-RETICULUM STRESS;
   RESPIRATORY-CHAIN SUPERCOMPLEXES; ISCHEMIA-REPERFUSION INJURY;
   INITIATION-FACTOR 2B; ER-STRESS; IN-VITRO; EIF2-ALPHA DEPHOSPHORYLATION;
   NUCLEOTIDE EXCHANGE; QUALITY CONTROL
AB The integrated stress response (ISR) triggered in response to various cellular stress enables mammalian cells to effectively cope with diverse stressful conditions while maintaining their normal functions. Four kinases (PERK, PKR, GCN2, and HRI) of ISR regulate ISR signaling and intracellular protein translation via mediating the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2 alpha) at Ser51. Early ISR creates an opportunity for cells to repair themselves and restore homeostasis. This effect, however, is reversed in the late stages of ISR. Currently, some studies have shown the non-negligible impact of ISR on diseases such as ischemic diseases, cognitive impairment, metabolic syndrome, cancer, vanishing white matter, etc. Hence, artificial regulation of ISR and its signaling with ISR modulators becomes a promising therapeutic strategy for relieving disease symptoms and improving clinical outcomes. Here, we provide an overview of the essential mechanisms of ISR and describe the ISR-related pathways in organelles including mitochondria, endoplasmic reticulum, Golgi apparatus, and lysosomes. Meanwhile, the regulatory effects of ISR modulators and their potential application in various diseases are also enumerated.
C1 [Lu, Hao-jun; Koju, Nirmala; Sheng, Rui] Soochow Univ, Coll Pharmaceut Sci, Jiangsu Key Lab Neuropsychiat Dis, Dept Pharmacol, Suzhou 215123, Peoples R China.
   [Lu, Hao-jun; Koju, Nirmala; Sheng, Rui] Soochow Univ, Coll Pharmaceut Sci, Lab Aging & Nervous Dis, Jiangsu Key Lab Neuropsychiat Dis, Suzhou 215123, Peoples R China.
C3 Soochow University - China; Soochow University - China
RP Sheng, R (corresponding author), Soochow Univ, Coll Pharmaceut Sci, Jiangsu Key Lab Neuropsychiat Dis, Dept Pharmacol, Suzhou 215123, Peoples R China.; Sheng, R (corresponding author), Soochow Univ, Coll Pharmaceut Sci, Lab Aging & Nervous Dis, Jiangsu Key Lab Neuropsychiat Dis, Suzhou 215123, Peoples R China.
EM sheng_rui@163.com
RI Sheng, Rui/N-5436-2017
FU National Natural Science Foundation of China [82173811, 81973315];
   Jiangsu Key Laboratory of Neuropsychiatric Diseases [BM2013003];
   Priority Academic Program Development of the Jiangsu Higher Education
   Institutes (PAPD); Suzhou International Joint Laboratory for Diagnosis
   and Treatment of Brain Diseases
FX This work was supported by grants from the National Natural Science
   Foundation of China (No. 82173811, 81973315), Jiangsu Key Laboratory of
   Neuropsychiatric Diseases (BM2013003), Priority Academic Program
   Development of the Jiangsu Higher Education Institutes (PAPD) and Suzhou
   International Joint Laboratory for Diagnosis and Treatment of Brain
   Diseases.
CR Abbink TEM, 2019, ANN CLIN TRANSL NEUR, V6, P1407, DOI 10.1002/acn3.50826
   Abdel-Nour M, 2019, SCIENCE, V365, P47, DOI 10.1126/science.aaw4144
   Adomavicius T, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-10167-3
   Al-Baghdadi RJT, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-01041-7
   Alavi MV, 2021, ACS CHEM BIOL, V16, P2202, DOI 10.1021/acschembio.1c00350
   Aldridge JE, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0000874
   Allen JE, 2015, MOL CANCER, V14, DOI 10.1186/s12943-015-0346-9
   Almeida LM, 2023, ARCH BIOCHEM BIOPHYS, V745, DOI 10.1016/j.abb.2023.109711
   Almeida LM, 2022, BIOL REV, V97, P1737, DOI 10.1111/brv.12860
   Alsina KM, 2019, CIRCULATION, V140, P681, DOI 10.1161/CIRCULATIONAHA.119.039642
   Alsterda A, 2021, FRONT ONCOL, V11, DOI 10.3389/fonc.2021.654940
   Amoroso MR, 2012, CELL DEATH DIFFER, V19, P592, DOI 10.1038/cdd.2011.128
   Anuncibay-Soto B, 2016, J NEUROCHEM, V138, P295, DOI 10.1111/jnc.13651
   Atkins C, 2013, CANCER RES, V73, P1993, DOI 10.1158/0008-5472.CAN-12-3109
   Averous J, 2016, SCI REP-UK, V6, DOI 10.1038/srep27698
   Axten JM, 2013, ACS MED CHEM LETT, V4, P964, DOI 10.1021/ml400228e
   Axten JM, 2012, J MED CHEM, V55, P7193, DOI 10.1021/jm300713s
   Bagratuni T, 2020, CANCERS, V12, DOI 10.3390/cancers12102864
   Bai XP, 2021, REDOX BIOL, V43, DOI 10.1016/j.redox.2021.101993
   Baker MJ, 2014, EMBO J, V33, P578, DOI 10.1002/embj.201386474
   Baker MJ, 2011, CSH PERSPECT BIOL, V3, DOI 10.1101/cshperspect.a007559
   Baker TA, 2012, BBA-MOL CELL RES, V1823, P15, DOI 10.1016/j.bbamcr.2011.06.007
   Balakrishnan B, 2019, BBA-MOL BASIS DIS, V1865, DOI 10.1016/j.bbadis.2019.07.010
   Balsa E, 2019, MOL CELL, V74, P877, DOI 10.1016/j.molcel.2019.03.031
   Bao XR, 2016, ELIFE, V5, DOI 10.7554/eLife.10575
   Barbezier N, 2011, EMBO MOL MED, V3, P35, DOI 10.1002/emmm.201000109
   Barua D, 2020, CANCER LETT, V486, P29, DOI 10.1016/j.canlet.2020.05.020
   Bender T, 2010, PROTEOMICS, V10, P1426, DOI 10.1002/pmic.200800619
   Benmerzouga I, 2015, ANTIMICROB AGENTS CH, V59, P6939, DOI 10.1128/AAC.01683-15
   Bezawork-Geleta A, 2015, SCI REP-UK, V5, DOI 10.1038/srep17397
   Bhattacharya B, 2021, J CLIN INVEST, V131, DOI 10.1172/JCI130319
   Bhola PD, 2016, MOL CELL, V61, P695, DOI 10.1016/j.molcel.2016.02.019
   Boesen T, 2004, J BIOL CHEM, V279, P10584, DOI 10.1074/jbc.M311055200
   Bogorad AM, 2017, NUCLEIC ACIDS RES, V45, P11962, DOI 10.1093/nar/gkx845
   Bohovych I, 2016, MOL CELL BIOL, V36, P2300, DOI 10.1128/MCB.00156-16
   Bollen M, 2010, TRENDS BIOCHEM SCI, V35, P450, DOI 10.1016/j.tibs.2010.03.002
   Bonner ER, 2021, NEURO-ONCOLOGY, V23, P542, DOI 10.1093/neuonc/noaa283
   Boyce M, 2005, SCIENCE, V307, P935, DOI 10.1126/science.1101902
   Brady RD, 2021, NEUROTRAUMA REP, V2, P330, DOI 10.1089/neur.2021.0001
   Bruch J, 2017, EMBO MOL MED, V9, P371, DOI 10.15252/emmm.201606664
   Bugallo R, 2020, CELL DEATH DIS, V11, DOI 10.1038/s41419-020-2601-2
   Burton TD, 2020, J BIOL CHEM, V295, P7418, DOI 10.1074/jbc.RA119.011864
   Cai WR, 2021, CANCER LETT, V515, P86, DOI 10.1016/j.canlet.2021.05.021
   Cankara FN, 2022, IMMUNOPHARM IMMUNOT, V44, P168, DOI 10.1080/08923973.2021.2023174
   Cantor E, 2022, NEURO-ONCOLOGY, V24, P1366, DOI 10.1093/neuonc/noac030
   Castilho BA, 2014, BBA-MOL CELL RES, V1843, P1948, DOI 10.1016/j.bbamcr.2014.04.006
   Cerrato G, 2021, AUTOPHAGY, V17, P820, DOI 10.1080/15548627.2020.1861836
   Chaurasia M, 2019, AUTOPHAGY, V15, P1391, DOI 10.1080/15548627.2019.1582973
   Chen JJ, 2007, BLOOD, V109, P2693, DOI 10.1182/blood-2006-08-041830
   Chen JJ, 2019, BLOOD, V134, P1697, DOI 10.1182/blood.2019001915
   Chen MC, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9091101
   Chen RM, 2015, ELIFE, V4, DOI 10.7554/eLife.04871
   Chen YA, 2019, BRAIN, V142, P344, DOI 10.1093/brain/awy322
   Chou A, 2017, P NATL ACAD SCI USA, V114, pE6420, DOI 10.1073/pnas.1707661114
   Chung HK, 2017, J CELL BIOL, V216, P149, DOI 10.1083/jcb.201607110
   Cnop M, 2017, MOL METAB, V6, P1024, DOI 10.1016/j.molmet.2017.06.001
   Cogliati S, 2013, CELL, V155, P160, DOI 10.1016/j.cell.2013.08.032
   Costa-Mattioli M, 2020, SCIENCE, V368, P384, DOI 10.1126/science.aat5314
   Crespillo-Casado A, 2018, J BIOL CHEM, V293, P7766, DOI 10.1074/jbc.RA118.002325
   Crespillo-Casado A, 2017, ELIFE, V6, DOI 10.7554/eLife.26109
   Daito T, 2014, GASTROENTEROLOGY, V147, P463, DOI 10.1053/j.gastro.2014.04.035
   Das I, 2015, SCIENCE, V348, P239, DOI 10.1126/science.aaa4484
   Davidson S, 2022, SCI IMMUNOL, V7, DOI 10.1126/sciimmunol.abi6763
   Davuluri G, 2016, J HEPATOL, V65, P929, DOI 10.1016/j.jhep.2016.06.004
   De Gassart A, 2016, P NATL ACAD SCI USA, V113, pE117, DOI 10.1073/pnas.1514076113
   Deng J, 2002, CURR BIOL, V12, P1279, DOI 10.1016/S0960-9822(02)01037-0
   Dhir N, 2023, METAB BRAIN DIS, V38, P1177, DOI 10.1007/s11011-023-01183-w
   Di Conza G, 2023, NAT REV IMMUNOL, DOI 10.1038/s41577-023-00838-0
   Dominguez-Bautista JA, 2015, EUR J CELL BIOL, V94, P148, DOI 10.1016/j.ejcb.2015.01.003
   Donnelly N, 2013, CELL MOL LIFE SCI, V70, P3493, DOI 10.1007/s00018-012-1252-6
   Emam AM, 2021, LIFE SCI, V283, DOI 10.1016/j.lfs.2021.119865
   Fan FF, 2020, CELL DEATH DIFFER, V27, P587, DOI 10.1038/s41418-019-0374-x
   Fan YL, 2022, FRONT ONCOL, V12, DOI 10.3389/fonc.2022.789450
   Fessler E, 2020, NATURE, V579, P433, DOI 10.1038/s41586-020-2076-4
   Fiorese CJ, 2016, CURR BIOL, V26, P2037, DOI 10.1016/j.cub.2016.06.002
   Fogli A, 2004, EUR J HUM GENET, V12, P561, DOI 10.1038/sj.ejhg.5201189
   Fogli A, 2003, AM J HUM GENET, V72, P1544, DOI 10.1086/375404
   Forsström S, 2019, CELL METAB, V30, P1040, DOI [10.1016/j.cmet.2019.013.019, 10.1016/j.cmet.2019.08.019]
   Fujita Y, 2015, MITOCHONDRION, V20, P34, DOI 10.1016/j.mito.2014.10.006
   Fusade-Boyer M, 2019, FRONT IMMUNOL, V10, DOI 10.3389/fimmu.2019.00134
   Gambardella G, 2020, SCI ADV, V6, DOI 10.1126/sciadv.abb0205
   Ganz J, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-63899-4
   Gao JY, 2021, BIOFACTORS, V47, P964, DOI 10.1002/biof.1780
   Ghaddar N, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-24661-0
   Ghadge GD, 2020, NEUROBIOL DIS, V136, DOI 10.1016/j.nbd.2019.104702
   Gibellini L, 2020, INT REV CEL MOL BIO, V354, P1, DOI 10.1016/bs.ircmb.2020.02.005
   Girardin SE, 2021, FEBS J, V288, P3094, DOI 10.1111/febs.15553
   Gispert S, 2013, HUM MOL GENET, V22, P4871, DOI 10.1093/hmg/ddt338
   Gonzalez-Teuber V, 2019, TRENDS PHARMACOL SCI, V40, P684, DOI 10.1016/j.tips.2019.07.003
   Grande V, 2018, HUM MOL GENET, V27, P2477, DOI 10.1093/hmg/ddy152
   Gundu Chayanika, 2022, Curr Res Pharmacol Drug Discov, V3, P100087, DOI 10.1016/j.crphar.2022.100087
   Guo XY, 2020, NATURE, V579, P427, DOI 10.1038/s41586-020-2078-2
   Gurzeler LA, 2022, RNA BIOL, V19, P78, DOI 10.1080/15476286.2021.2014695
   Haggag YA, 2021, INT J PHARMACEUT, V600, DOI 10.1016/j.ijpharm.2021.120532
   Hahn CK, 2013, BLOOD, V122, P477, DOI 10.1182/blood-2013-03-491043
   Halliday M, 2015, CELL DEATH DIS, V6, DOI 10.1038/cddis.2015.49
   Hamamura K, 2015, BONE JOINT RES, V4, P84, DOI 10.1302/2046-3758.45.2000378
   Hamamura K, 2013, OSTEOARTHR CARTILAGE, V21, P764, DOI 10.1016/j.joca.2013.02.657
   Hamamura K, 2015, CELL SIGNAL, V27, P353, DOI 10.1016/j.cellsig.2014.11.020
   Hamon MP, 2015, AGEING RES REV, V23, P56, DOI 10.1016/j.arr.2014.12.010
   Han J, 2013, NAT CELL BIOL, V15, P481, DOI 10.1038/ncb2738
   Harada T, 2010, APOPTOSIS, V15, P1247, DOI 10.1007/s10495-010-0519-3
   Harding HP, 2012, J BIOL CHEM, V287, P44338, DOI 10.1074/jbc.M112.428987
   Hart LS, 2012, J CLIN INVEST, V122, P4621, DOI 10.1172/JCI62973
   Haynes CM, 2010, J CELL SCI, V123, P3849, DOI 10.1242/jcs.075119
   He L, 2013, CELL SIGNAL, V25, P552, DOI 10.1016/j.cellsig.2012.11.015
   Hiller H, 2021, DIABETES, V70, P1885, DOI 10.2337/db21-0070
   Hinnebusch AG, 2005, ANNU REV MICROBIOL, V59, P407, DOI 10.1146/annurev.micro.59.031805.133833
   Hinnebusch AG, 2016, SCIENCE, V352, P1413, DOI 10.1126/science.aad9868
   Hinnebusch AG, 2014, ANNU REV BIOCHEM, V83, P779, DOI 10.1146/annurev-biochem-060713-035802
   Hori O, 2002, J CELL BIOL, V157, P1151, DOI 10.1083/jcb.200108103
   Hu XM, 2021, ENDOCR REV, V42, P56, DOI 10.1210/endrev/bnaa026
   Huang SY, 2020, AM J PHYSIOL-CELL PH, V319, pC1020, DOI 10.1152/ajpcell.00589.2019
   Huang XM, 2012, NEUROBIOL AGING, V33, DOI 10.1016/j.neurobiolaging.2011.10.007
   Hughes D, 2019, FEBS J, V286, P342, DOI 10.1111/febs.14422
   Hugon J, 2017, ALZHEIMERS RES THER, V9, DOI 10.1186/s13195-017-0308-0
   Ichim G, 2016, NAT REV CANCER, V16, P539, DOI 10.1038/nrc.2016.58
   Ishizawa J, 2019, CANCER CELL, V35, P721, DOI 10.1016/j.ccell.2019.03.014
   Ishizawa J, 2016, SCI SIGNAL, V9, DOI 10.1126/scisignal.aac4380
   Jewer M, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-16352-z
   Ji C, 2017, BIOCHEM BIOPH RES CO, V493, P1371, DOI 10.1016/j.bbrc.2017.10.012
   Jiang Q, 2014, CELL DEATH DIS, V5, DOI 10.1038/cddis.2014.200
   Jiang XT, 2017, MOL MED REP, V15, P3105, DOI 10.3892/mmr.2017.6418
   Jin SM, 2013, AUTOPHAGY, V9, P1750, DOI 10.4161/auto.26122
   Jin ZZ, 2016, BIOCHEM BIOPH RES CO, V478, P1515, DOI 10.1016/j.bbrc.2016.08.126
   Jousse C, 2003, J CELL BIOL, V163, P767, DOI 10.1083/jcb.200308075
   Kabir ZD, 2017, MOL PSYCHIATR, V22, P1096, DOI 10.1038/mp.2017.124
   Kalkavan H, 2022, CELL, V185, P3356, DOI 10.1016/j.cell.2022.07.025
   Kang SG, 2021, ISCIENCE, V24, DOI 10.1016/j.isci.2021.102181
   Kao TY, 2015, CELL DEATH DIS, V6, DOI 10.1038/cddis.2015.9
   Kasai S, 2019, J CLIN BIOCHEM NUTR, V64, P1, DOI 10.3164/jcbn.18-37
   Kasetti RB, 2020, NAT COMMUN, V11, DOI 10.1038/s41467-020-19352-1
   Kashiwagi K, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-27337-x
   Kashiwagi K, 2019, SCIENCE, V364, P495, DOI 10.1126/science.aaw4104
   Kaspar S, 2021, SCI ADV, V7, DOI 10.1126/sciadv.abf0971
   Kenner LR, 2019, SCIENCE, V364, P491, DOI 10.1126/science.aaw2922
   Khan NA, 2017, CELL METAB, V26, P419, DOI 10.1016/j.cmet.2017.07.007
   Kim KH, 2013, NAT MED, V19, P83, DOI 10.1038/nm.3014
   Kim MJ, 2018, J ENDOCRINOL, V236, P125, DOI 10.1530/JOE-17-0497
   Kimura F, 2021, LIFE SCI, V284, DOI 10.1016/j.lfs.2021.119938
   Klann K, 2020, MOL CELL, V77, P913, DOI 10.1016/j.molcel.2019.11.010
   Kopp MC, 2019, NAT STRUCT MOL BIOL, V26, P1053, DOI 10.1038/s41594-019-0324-9
   Kotanska M, 2022, N-S ARCH PHARMACOL, V395, P963, DOI 10.1007/s00210-022-02251-1
   Kouroku Y, 2007, CELL DEATH DIFFER, V14, P230, DOI 10.1038/sj.cdd.4401984
   Krukowski K, 2020, ELIFE, V9, DOI 10.7554/eLife.62048
   Leegwater PAJ, 2001, NAT GENET, V29, P383, DOI 10.1038/ng764
   Lei YP, 2021, BIOCHEM BIOPH RES CO, V557, P316, DOI 10.1016/j.bbrc.2021.03.041
   Li J, 2020, CELL DEATH DIS, V11, DOI 10.1038/s41419-020-03264-5
   Li J, 2019, CELL DEATH DIS, V10, DOI 10.1038/s41419-019-2159-z
   Li LF, 2022, BIOCHEM BIOPH RES CO, V610, P70, DOI 10.1016/j.bbrc.2022.04.041
   Li QQ, 2019, CELL REP, V28, P3406, DOI 10.1016/j.celrep.2019.08.066
   Li W, 2016, DRUG RESIST UPDATE, V27, P14, DOI 10.1016/j.drup.2016.05.001
   Li WM, 2017, NAT COMMUN, V8, DOI 10.1038/s41467-017-01609-x
   Li XL, 2020, FRONT PHARMACOL, V11, DOI 10.3389/fphar.2020.00737
   Li Y, 2018, AGING-US, V10, P1902, DOI 10.18632/aging.101511
   Li ZX, 2022, GASTROENTEROLOGY, V162, P1256, DOI 10.1053/j.gastro.2021.12.249
   Lim B, 2021, BIOMEDICINES, V9, DOI 10.3390/biomedicines9101410
   Lin CCE, 2021, CELL DEATH DIS, V12, DOI 10.1038/s41419-021-04018-7
   Liu DQ, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-05488-6
   Liu SS, 2022, FEBS J, V289, P6994, DOI 10.1111/febs.16323
   Liu SS, 2021, CELL METAB, V33, P1974, DOI 10.1016/j.cmet.2021.06.013
   Liu XD, 2021, J HAZARD MATER, V417, DOI 10.1016/j.jhazmat.2021.125997
   Liu Y, 2010, COGN NEURODYNAMICS, V4, P61, DOI 10.1007/s11571-009-9100-6
   Loeuillard E, 2018, BBA-MOL BASIS DIS, V1864, P3688, DOI 10.1016/j.bbadis.2018.10.008
   Lopez NH, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0261799
   Lu M, 2014, SCIENCE, V345, P98, DOI 10.1126/science.1254312
   Lu PD, 2004, J CELL BIOL, V167, P27, DOI 10.1083/jcb.200408003
   Lu W, 2022, FRONT MOL NEUROSCI, V15, DOI 10.3389/fnmol.2022.916458
   Malhi H, 2011, J HEPATOL, V54, P795, DOI 10.1016/j.jhep.2010.11.005
   Mangali S, 2019, J CELL BIOCHEM, V120, P3651, DOI 10.1002/jcb.27643
   Marlin E, 2024, BRIT J PHARMACOL, V181, P495, DOI 10.1111/bph.16260
   Martinez NW, 2021, FRONT AGING NEUROSCI, V13, DOI 10.3389/fnagi.2021.638208
   Martynowicz J, 2019, MBIO, V10, DOI [10.1128/mBio.00381-19, 10.1128/mbio.00381-19]
   Matassa DS, 2013, CELL DEATH DIS, V4, DOI 10.1038/cddis.2013.379
   Matsushima Y, 2021, COMMUN BIOL, V4, DOI 10.1038/s42003-021-02498-z
   Mayer MP, 2005, CELL MOL LIFE SCI, V62, P670, DOI 10.1007/s00018-004-4464-6
   McCaughey J, 2019, TRENDS CELL BIOL, V29, P940, DOI 10.1016/j.tcb.2019.08.007
   McElroy GS, 2020, CELL METAB, V32, P301, DOI 10.1016/j.cmet.2020.06.003
   MEACHAM RH, 1980, J PHARMACOL EXP THER, V214, P594
   Menacho-Marquez M, 2007, CELL CYCLE, V6, P2302, DOI 10.4161/cc.6.18.4668
   Mercado G, 2018, NEUROBIOL DIS, V112, P136, DOI 10.1016/j.nbd.2018.01.004
   Mick E, 2020, ELIFE, V9, DOI 10.7554/eLife.49178
   Miyake M, 2021, ISCIENCE, V24, DOI 10.1016/j.isci.2021.103448
   Moon SL, 2018, RNA, V24, P841, DOI 10.1261/rna.066563.118
   Mujcic H, 2009, RADIOTHER ONCOL, V92, P450, DOI 10.1016/j.radonc.2009.08.017
   Münch C, 2016, NATURE, V534, P710, DOI 10.1038/nature18302
   Muramatsu R, 2021, J PHARMACOL SCI, V147, P294, DOI 10.1016/j.jphs.2021.08.003
   Nagasawa I, 2017, BIOCHEM BIOPH RES CO, V482, P1491, DOI 10.1016/j.bbrc.2016.12.062
   Nagelkerke A, 2013, RADIOTHER ONCOL, V108, P415, DOI 10.1016/j.radonc.2013.06.037
   Nagelkerke A, 2013, BREAST CANCER RES, V15, DOI 10.1186/bcr3373
   Nagiah S, 2016, CHEM-BIOL INTERACT, V252, P82, DOI 10.1016/j.cbi.2016.03.021
   Nakagawa T, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20112761
   Nakamura T, 2010, CELL, V140, P338, DOI 10.1016/j.cell.2010.01.001
   Nan JL, 2019, J CELL SCI, V132, DOI 10.1242/jcs.220871
   Nguyen HG, 2018, SCI TRANSL MED, V10, DOI 10.1126/scitranslmed.aar2036
   Nikonorova IA, 2018, J BIOL CHEM, V293, P5005, DOI 10.1074/jbc.RA117.001625
   Novoa I, 2001, J CELL BIOL, V153, P1011, DOI 10.1083/jcb.153.5.1011
   Nunnari J, 2012, CELL, V148, P1145, DOI 10.1016/j.cell.2012.02.035
   Ohri SS, 2023, J NEUROTRAUM, V40, P1007, DOI 10.1089/neu.2022.0177
   Oliveira MM, 2021, SCI SIGNAL, V14, DOI 10.1126/scisignal.abc5429
   Onat UI, 2019, J AM COLL CARDIOL, V73, P1149, DOI 10.1016/j.jacc.2018.12.055
   Ost M, 2016, MOL METAB, V5, P79, DOI 10.1016/j.molmet.2015.11.002
   Page AB, 2003, ACTA NEUROPATHOL, V106, P8, DOI 10.1007/s00401-003-0693-2
   Pakos-Zebrucka K, 2016, EMBO REP, V17, P1374, DOI 10.15252/embr.201642195
   Palam LR, 2011, J BIOL CHEM, V286, P10939, DOI 10.1074/jbc.M110.216093
   Pan B, 2021, J ADV RES, V33, P215, DOI 10.1016/j.jare.2021.01.016
   Pathak SS, 2019, NEURON, V104, P724, DOI 10.1016/j.neuron.2019.08.007
   Philippe C, 2016, SCI SIGNAL, V9, DOI 10.1126/scisignal.aaf2753
   Philips AM, 2021, OBES REV, V22, DOI 10.1111/obr.13221
   Picard M, 2022, CELL METAB, V34, P1620, DOI 10.1016/j.cmet.2022.10.008
   Prabhu VV, 2020, NEOPLASIA, V22, P725, DOI 10.1016/j.neo.2020.09.005
   Pu Y, 2019, AM J TRANSL RES, V11, P5586
   Quirós PM, 2017, J CELL BIOL, V216, P2027, DOI 10.1083/jcb.201702058
   Quirós PM, 2014, CELL REP, V8, P541, DOI 10.1016/j.celrep.2014.06.018
   Rabouw HH, 2019, P NATL ACAD SCI USA, V116, P2097, DOI 10.1073/pnas.1815767116
   Rasola A, 2014, TRENDS CELL BIOL, V24, P455, DOI 10.1016/j.tcb.2014.03.005
   Ravindran R, 2016, NATURE, V531, P523, DOI 10.1038/nature17186
   Ravishankar B, 2015, P NATL ACAD SCI USA, V112, P10774, DOI 10.1073/pnas.1504276112
   Reid DW, 2016, MOL CELL BIOL, V36, P1868, DOI 10.1128/MCB.00190-16
   Rendón OZ, 2018, MOL CELL BIOL, V38, DOI 10.1128/MCB.00412-17
   Ri M, 2012, BLOOD CANCER J, V2, DOI 10.1038/bcj.2012.26
   Romero-Ramírez L, 2017, BIOMED RES INT, V2017, DOI 10.1155/2017/6953156
   Ross JA, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19124032
   Rubovitch V, 2015, NEUROMOL MED, V17, P58, DOI 10.1007/s12017-015-8340-3
   Ruiz A, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21176088
   Sabnis AJ, 2016, P NATL ACAD SCI USA, V113, P9015, DOI 10.1073/pnas.1603883113
   Santos CXC, 2016, EMBO J, V35, P319, DOI 10.15252/embj.201592394
   Santos-Ribeiro D, 2018, DRUG DISCOV TODAY, V23, P920, DOI 10.1016/j.drudis.2018.02.008
   Sbodio JI, 2018, P NATL ACAD SCI USA, V115, P780, DOI 10.1073/pnas.1717877115
   Schiffmann R, 2006, MOL GENET METAB, V88, P7, DOI 10.1016/j.ymgme.2005.10.019
   Sciarretta S, 2013, CIRC RES, V113, P1253, DOI 10.1161/CIRCRESAHA.113.301787
   Sekine Y, 2015, SCIENCE, V348, P1027, DOI 10.1126/science.aaa6986
   Sen T, 2017, J NEUROSCI, V37, P5900, DOI 10.1523/JNEUROSCI.2343-16.2017
   Seo JH, 2016, PLOS BIOL, V14, DOI 10.1371/journal.pbio.1002507
   SHAH RS, 1976, CLIN PHARMACOL THER, V19, P732
   Sharma R, 2017, ONCOTARGET, V8, P967, DOI 10.18632/oncotarget.13514
   Sharon D, 2017, BLOOD, V130
   Shi SZ, 2023, INVEST OPHTH VIS SCI, V64, DOI 10.1167/iovs.64.11.17
   Shi YG, 2009, CELL, V139, P468, DOI 10.1016/j.cell.2009.10.006
   Shi Z, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-39547-x
   Shin CS, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-020-20597-z
   Sidrauski C, 2015, ELIFE, V4, DOI 10.7554/eLife.07314
   Sidrauski C, 2015, ELIFE, V4, DOI 10.7554/eLife.05033
   Sidrauski C, 2013, ELIFE, V2, DOI 10.7554/eLife.00498
   Singh A, 2022, CELL TISSUE RES, V388, P239, DOI 10.1007/s00441-021-03570-0
   Soni H, 2020, ONCOGENESIS, V9, DOI 10.1038/s41389-020-0201-8
   Stein MN, 2017, CLIN CANCER RES, V23, P4163, DOI 10.1158/1078-0432.CCR-16-2658
   Stockwell SR, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0028568
   Sun WM, 2017, CELL BIOSCI, V7, DOI 10.1186/s13578-017-0196-9
   Sun XT, 2018, EXP NEUROL, V303, P95, DOI 10.1016/j.expneurol.2018.01.015
   Suomalainen A, 2018, NAT REV MOL CELL BIO, V19, P77, DOI 10.1038/nrm.2017.66
   Szegezdi E, 2006, EMBO REP, V7, P880, DOI 10.1038/sj.embor.7400779
   Takigawa S, 2016, J PHARMACOL SCI, V132, P154, DOI 10.1016/j.jphs.2016.09.006
   Tang XM, 2021, CELL METAB, V33, P1577, DOI 10.1016/j.cmet.2021.05.015
   Teske BF, 2011, MOL BIOL CELL, V22, P4390, DOI 10.1091/mbc.E11-06-0510
   Thompson KK, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-76383-w
   Tian XB, 2021, FRONT PHARMACOL, V12, DOI 10.3389/fphar.2021.747837
   Torrence ME, 2021, ELIFE, V10, DOI 10.7554/eLife.63326
   Tsai JC, 2018, SCIENCE, V359, P1483, DOI 10.1126/science.aaq0939
   Tsang JOL, 2020, THESIS HONGKONG U CH
   Tsaytler P, 2011, SCIENCE, V332, P91, DOI 10.1126/science.1201396
   van Galen P, 2018, CELL REP, V25, P1109, DOI 10.1016/j.celrep.2018.10.021
   Vandewynckel YP, 2015, HEPATOL INT, V9, P93, DOI 10.1007/s12072-014-9582-0
   Vanhoutte D, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-24215-4
   Varanita T, 2015, CELL METAB, V21, P834, DOI 10.1016/j.cmet.2015.05.007
   Vattem KM, 2004, P NATL ACAD SCI USA, V101, P11269, DOI 10.1073/pnas.0400541101
   Vieira FG, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0135570
   WALKER BR, 1982, J INT MED RES, V10, P6, DOI 10.1177/030006058201000102
   Walter P, 2011, SCIENCE, V334, P1081, DOI 10.1126/science.1209038
   Wang C, 2018, ELIFE, V7, DOI 10.7554/eLife.37673
   Wang LJ, 2014, NEUROBIOL DIS, V71, P317, DOI 10.1016/j.nbd.2014.08.010
   Wang P, 2019, J ALLERGY CLIN IMMUN, V144, P1091, DOI 10.1016/j.jaci.2019.04.028
   Wang RJ, 2023, ISCIENCE, V26, DOI 10.1016/j.isci.2023.105954
   Wang YC, 2020, STROKE, V51, P1570, DOI 10.1161/STROKEAHA.120.029071
   Wang ZF, 2019, NEUROBIOL LEARN MEM, V161, P12, DOI 10.1016/j.nlm.2019.03.002
   Wardelmann K, 2019, MOL METAB, V21, P68, DOI 10.1016/j.molmet.2019.01.001
   Watanabe S, 2021, P NATL ACAD SCI USA, V118, DOI 10.1073/pnas.2101100118
   Wek RC, 2018, CSH PERSPECT BIOL, V10, DOI 10.1101/cshperspect.a032870
   Wengrod JC, 2015, CELL CYCLE, V14, P2571, DOI 10.1080/15384101.2015.1056947
   Witkamp D, 2022, ANN CLIN TRANSL NEUR, V9, P1147, DOI 10.1002/acn3.51611
   Wong YL, 2019, ELIFE, V8, DOI 10.7554/eLife.42940
   Wong YL, 2018, ELIFE, V7, DOI 10.7554/eLife.32733
   Wortel IMN, 2017, TRENDS ENDOCRIN MET, V28, P794, DOI 10.1016/j.tem.2017.07.003
   Wu CT, 2011, FREE RADICAL BIO MED, V51, P671, DOI 10.1016/j.freeradbiomed.2011.04.038
   Xia XJ, 2018, CELL DEATH DISCOV, V4, DOI 10.1038/s41420-017-0022-5
   Xie H, 2018, J CLIN INVEST, V128, P1300, DOI 10.1172/JCI95864
   Xu X, 2018, HEPATOLOGY, V68, P2167, DOI 10.1002/hep.30060
   Yang TH, 2021, NEUROSCI LETT, V758, DOI 10.1016/j.neulet.2021.136004
   Yokota H, 2013, BMC MUSCULOSKEL DIS, V14, DOI 10.1186/1471-2474-14-197
   Yoon L, 2022, MTOR INHIBITOR INDEP, V2022
   Yoshino S, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-70689-5
   You K, 2021, SCIENCE, V371, P45, DOI 10.1126/science.abb6896
   Young-Baird SK, 2020, MOL CELL, V77, P875, DOI 10.1016/j.molcel.2019.11.008
   Yu LM, 2016, APOPTOSIS, V21, P809, DOI 10.1007/s10495-016-1246-1
   Zhang D, 2022, NAT CELL BIOL, V24, P766, DOI 10.1038/s41556-022-00894-z
   Zhang GY, 2021, CIRCULATION, V144, P1500, DOI 10.1161/CIRCULATIONAHA.120.053125
   Zhang GY, 2022, CELL DEATH DIFFER, V29, P750, DOI 10.1038/s41418-021-00889-7
   Zhang JN, 2022, BIOCHEM PHARMACOL, V204, DOI 10.1016/j.bcp.2022.115232
   Zhang J, 2019, J CELL PHYSIOL, V234, P19728, DOI 10.1002/jcp.28572
   Zhang JC, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/7468738
   Zhang M, 2020, CELL, V181, P637, DOI 10.1016/j.cell.2020.03.031
   Zhang P, 2012, J BONE MINER METAB, V30, P568, DOI 10.1007/s00774-012-0359-z
   Zhang R, 2022, AUTOPHAGY, V18, P816, DOI 10.1080/15548627.2021.1959086
   Zhang XH, 2017, BIOFACTORS, V43, P812, DOI 10.1002/biof.1380
   Zhang YJ, 2020, ANTIOXID REDOX SIGN, V32, P583, DOI 10.1089/ars.2019.7824
   Zhao Q, 2002, EMBO J, V21, P4411, DOI 10.1093/emboj/cdf445
   Zhao YY, 2017, ENVIRON POLLUT, V223, P587, DOI 10.1016/j.envpol.2017.01.061
   Zhu JF, 2022, EMBO REP, V23, DOI 10.15252/embr.202153937
   Zhu PJ, 2019, SCIENCE, V366, P843, DOI 10.1126/science.aaw5185
   Zielke S, 2021, AUTOPHAGY, V17, P2432, DOI 10.1080/15548627.2020.1827780
   Zyryanova AF, 2021, MOL CELL, V81, P88, DOI 10.1016/j.molcel.2020.10.031
   Zyryanova AF, 2018, SCIENCE, V359, P1533, DOI 10.1126/science.aar5129
NR 312
TC 15
Z9 16
U1 12
U2 41
PU NATURE PUBL GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1671-4083
EI 1745-7254
J9 ACTA PHARMACOL SIN
JI Acta Pharmacol. Sin.
PD JUN
PY 2024
VL 45
IS 6
BP 1095
EP 1114
DI 10.1038/s41401-023-01225-0
EA JAN 2024
PG 20
WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA SK6P7
UT WOS:001147845900002
PM 38267546
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Quetglas-Llabrés, MM
   Monserrat-Mesquida, M
   Bouzas, C
   García, S
   Mateos, D
   Ugarriza, L
   Gómez, C
   Sureda, A
   Tur, JA
AF Quetglas-Llabres, Maria Magdalena
   Monserrat-Mesquida, Margalida
   Bouzas, Cristina
   Garcia, Silvia
   Mateos, David
   Ugarriza, Lucia
   Gomez, Cristina
   Sureda, Antoni
   Tur, Josep A.
TI Long-Term Impact of Nutritional Intervention with Increased Polyphenol
   Intake and Physical Activity Promotion on Oxidative and Inflammatory
   Profiles in Patients with Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE obesity; cardiovascular disease; intervention; oxidative stress;
   inflammation
ID WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; ADIPOSE-TISSUE; OBESITY; STRESS;
   MANAGEMENT; MYELOPEROXIDASE; QUESTIONNAIRE; METAANALYSIS; ASSOCIATION
AB Obesity and overweight pose significant risks to health, contributing to the prevalence of chronic conditions like type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD). The current study aimed to assess the impact of a 6-year nutritional and lifestyle intervention on oxidative and inflammatory markers in individuals aged 55 to 75, specifically those at high risk of CVD. A study was carried out in a group of 80 participants with metabolic syndrome (MetS) residing in Mallorca, Spain, who underwent nutritional intervention based on a low-calorie Mediterranean diet (MedDiet) and promotion of physical activity. Before and after the intervention, several parameters including anthropometric data, haematological factors, blood pressure, and physical activity level were measured. Oxidative and inflammatory biomarkers in plasma were analysed. After the 6-year intervention, participants who managed to reduce their body mass index (BMI) had greater reductions in abdominal obesity, waist to heigh ratio (WHtR), diastolic blood pressure, and glucose levels, and increased high density protein cholesterol (HDL-c) compared to those who did not reduce BMI. This higher reduction in BMI was related to reduced energy intake and increased adherence to MedDiet, with greater polyphenol intake, and total physical activity (PA). Furthermore, improvements in oxidative stress and proinflammatory status were observed in participants who reduced their BMI. Significant reductions in the activity of the prooxidant enzyme, myeloperoxidase (MPO), levels of the lipid oxidation marker, malondialdehyde (MDA), and the proinflammatory chemokine, monocyte chemoattractant protein-1 (MCP-1,) were found in those who reduced their BMI. In contrast, participants who did not improve their BMI exhibited higher levels of proinflammatory markers such as MCP-1 and tumour necrosis factor alpha (TNF alpha), as well as increased activity of the antioxidant enzyme catalase (CAT). Current findings suggest that an effective way to reduce BMI is a hypocaloric MedDiet combined with tailored physical activity to improve oxidative stress and proinflammatory status, and potentially reducing the risk of CVD.
C1 [Quetglas-Llabres, Maria Magdalena; Monserrat-Mesquida, Margalida; Bouzas, Cristina; Garcia, Silvia; Mateos, David; Ugarriza, Lucia; Gomez, Cristina; Sureda, Antoni; Tur, Josep A.] Univ Balear Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.
   [Quetglas-Llabres, Maria Magdalena; Monserrat-Mesquida, Margalida; Bouzas, Cristina; Garcia, Silvia; Mateos, David; Ugarriza, Lucia; Gomez, Cristina; Sureda, Antoni; Tur, Josep A.] Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca 07120, Spain.
   [Quetglas-Llabres, Maria Magdalena; Monserrat-Mesquida, Margalida; Bouzas, Cristina; Garcia, Silvia; Mateos, David; Ugarriza, Lucia; Sureda, Antoni; Tur, Josep A.] Inst Salud Carlos III, Physiopathol Obes & Nutr CIBEROBN, Madrid 28029, Spain.
   [Gomez, Cristina] Univ Hosp Son Espases, Clin Anal Serv, Palma De Mallorca 07198, Spain.
C3 Institut Investigacio Sanitaria Illes Balears (IdISBa); Instituto de
   Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEROBN; Hospital Universitari Son Espases
RP Sureda, A (corresponding author), Univ Balear Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Sureda, A (corresponding author), Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca 07120, Spain.; Sureda, A (corresponding author), Inst Salud Carlos III, Physiopathol Obes & Nutr CIBEROBN, Madrid 28029, Spain.
EM margalida.monserrat@uib.es; antoni.sureda@uib.es; pep.tur@uib.es
RI Bouzas, Cristina/AAE-2069-2019; Quetglas Llabrés, Maria/AAA-4412-2019;
   Tur, Josep/AAE-5748-2020; Mesquida, Margalida/AAB-4773-2019; Sureda,
   Antoni/N-9588-2019; Tur, Josep/F-5576-2014
OI Tur, Josep/0000-0002-6940-0761; Bouzas Velasco,
   Cristina/0000-0002-1407-8461; Monserrat Mesquida,
   Margalida/0000-0002-8856-135X; Garcia, Silvia/0000-0003-3534-1588;
   Quetglas Llabres, Maria Magdalena/0000-0003-4155-7780; ,
   Antoni/0000-0001-8656-6838; GOMEZ COBO, CRISTINA/0000-0002-9776-4730
FU Government of Balearic Islands, Direccio General de Politica
   Universitaria i Recerca [AP_2021_030]; IDISBA grant; SOIB-Investigo
   Program; Juan de la Cierva Program (Ministry of Science and Innovation,
   Spain; Margalida Comas Program (DG R+D+I, Balearic Islands Government,
   Spain); CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN)
   [CB12/03/30038]; Instituto de Salud Carlos III (ISCIII), through the
   Fondo de Investigacion para la Salud [FISP I20/00456]; European Regional
   Development Fund
FX This work was supported by the official Spanish Institutions for funding
   scientific biomedical research, CIBER Fisiopatologia de la Obesidad y
   Nutricion (CIBEROBN CB12/03/30038) and Instituto de Salud Carlos III
   (ISCIII), through the Fondo de Investigacion para la Salud (project FISP
   I20/00456), which is co-funded by the European Regional Development
   Fund. The work was also supported by the Government of Balearic Islands,
   Direccio General de Politica Universitaria i Recerca (AP_2021_030).
   M.M.Q.-L. was granted by IDISBA grant. M.M.M. and S.G. were granted by
   SOIB-Investigo Program. C.B. was granted by Juan de la Cierva Program
   (Ministry of Science and Innovation, Spain, and Margalida Comas Program
   (DG R+D+I, Balearic Islands Government, Spain). The funding sponsors had
   no role in the design of the study, in the collection, analyses, or
   interpretation of the data; in the writing of the manuscript, or in the
   decision to publish the results.
CR Abagre TA, 2022, BMC CARDIOVASC DISOR, V22, DOI 10.1186/s12872-022-02805-4
   Adenan DM, 2020, PEERJ, V8, DOI 10.7717/peerj.9230
   AEBI H, 1984, METHOD ENZYMOL, V105, P121
   AINSWORTH BE, 1993, MED SCI SPORT EXER, V25, P71, DOI 10.1249/00005768-199301000-00011
   Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
   [Anonymous], 2009, Plant Phenolics and Human Health: Biochemistry, Nutrition and Pharmacology, DOI DOI 10.1002/9780470531792
   Balentine DA, 2015, AM J CLIN NUTR, V101, P1113, DOI 10.3945/ajcn.113.071274
   Boudreau DM, 2009, METAB SYNDR RELAT D, V7, P305, DOI 10.1089/met.2008.0070
   Bouzas C, 2020, NUTRIENTS, V12, DOI 10.3390/nu12072114
   Capeillère-Blandin C, 1998, BIOCHEM J, V336, P395, DOI 10.1042/bj3360395
   Capó X, 2020, J PHARMACEUT BIOMED, V186, DOI 10.1016/j.jpba.2020.113258
   Chen SJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0045693
   Crujeiras AB, 2007, FREE RADICAL RES, V41, P498, DOI 10.1080/10715760601131935
   de la Rosa LA, 2019, POSTHARVEST PHYSIOLOGY AND BIOCHEMISTRY OF FRUITS AND VEGETABLES, P253, DOI 10.1016/B978-0-12-813278-4.00012-9
   Esposito K, 2011, METAB SYNDR RELAT D, V9, P1, DOI 10.1089/met.2010.0031
   Fernández-Ballarth JD, 2010, BRIT J NUTR, V103, P1808, DOI 10.1017/S0007114509993837
   FLOHE L, 1984, METHOD ENZYMOL, V105, P93
   Franz MJ, 2015, J ACAD NUTR DIET, V115, P1447, DOI 10.1016/j.jand.2015.02.031
   Fu CP, 2015, CLIN CHEM LAB MED, V53, P623, DOI 10.1515/cclm-2014-0468
   Furukawa S., 2004, Journal of Clinical Investigation, V114, P1752, DOI 10.1172/JCI21625
   García-Fontana B, 2015, INT J MOL SCI, V16, P9469, DOI 10.3390/ijms16059469
   Gasmi A, 2022, MOLECULES, V27, DOI 10.3390/molecules27196280
   Gouveia HJCB, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23158344
   Guan PY, 2024, J NUTR BIOCHEM, V130, DOI 10.1016/j.jnutbio.2024.109658
   Guo XH, 2017, NUTRIENTS, V9, DOI 10.3390/nu9050452
   Hall KD, 2018, MED CLIN N AM, V102, P183, DOI 10.1016/j.mcna.2017.08.012
   Hardy DS, 2020, NUTR METAB CARDIOVAS, V30, P853, DOI 10.1016/j.numecd.2019.12.050
   Jung SH, 2008, J NUTR BIOCHEM, V19, P371, DOI 10.1016/j.jnutbio.2007.05.007
   Kanda H, 2006, J CLIN INVEST, V116, P1494, DOI 10.1172/JCI26498
   Klebanoff SJ, 2005, J LEUKOCYTE BIOL, V77, P598, DOI 10.1189/jlb.1204697
   Kompaniyets L, 2023, JAMA NETW OPEN, V6, DOI 10.1001/jamanetworkopen.2023.27358
   Lastra G, 2013, HORM MOL BIOL CLIN I, V15, P49, DOI 10.1515/hmbci-2013-0025
   Lotfi K, 2022, ADV NUTR, V13, P152, DOI 10.1093/advances/nmab092
   Martínez-González MA, 2005, PUBLIC HEALTH NUTR, V8, P920, DOI 10.1079/PHN2005745
   Masenga SK, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24097898
   Monserrat-Mesquida M, 2022, ANTIOXIDANTS-BASEL, V11, DOI 10.3390/antiox11071326
   Monserrat-Mesquida M, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10050813
   Monserrat-Mesquida M, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9030236
   Moreiras O., 2018, Tablas de Composicion de Alimentos (Ciencia Y Tecnica). Gua de Prcticas, V19th ed., P37
   Moschen AR, 2011, MOL MED, V17, P840, DOI 10.2119/molmed.2010.00108
   Myers J, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071652
   Nani A, 2021, MOLECULES, V26, DOI 10.3390/molecules26040985
   Neveu V, 2010, DATABASE-OXFORD, DOI 10.1093/database/bap024
   Prieur X, 2010, BBA-MOL CELL BIOL L, V1801, P327, DOI 10.1016/j.bbalip.2009.09.017
   Ramaiah P, 2024, BMC ENDOCR DISORD, V24, DOI 10.1186/s12902-024-01556-x
   Rochlani Y, 2017, THER ADV CARDIO DIS, V11, P215, DOI 10.1177/1753944717711379
   Rothberg AE, 2017, BMJ OPEN DIAB RES CA, V5, DOI 10.1136/bmjdrc-2016-000341
   Ryder E, 2014, DIABETES METAB SYND, V8, P197, DOI 10.1016/j.dsx.2014.09.002
   Saklayen MG, 2018, CURR HYPERTENS REP, V20, DOI 10.1007/s11906-018-0812-z
   Shin JA, 2013, J DIABETES INVEST, V4, P334, DOI 10.1111/jdi.12075
   Sies H, 2015, REDOX BIOL, V4, P180, DOI 10.1016/j.redox.2015.01.002
   Tumova E, 2013, J OBES, V2013, DOI 10.1155/2013/729515
   Tussing-Humphreys L, 2022, PREV MED REP, V29, DOI 10.1016/j.pmedr.2022.101955
   van Baak MA, 2021, CURR OPIN CLIN NUTR, V24, P354, DOI 10.1097/MCO.0000000000000758
   Velázquez-López L, 2014, BMC PEDIATR, V14, DOI 10.1186/1471-2431-14-175
   Vona R, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8267234
   Wan YY, 2024, FRONT IMMUNOL, V15, DOI 10.3389/fimmu.2024.1380493
   Wong SK, 2020, INT J MED SCI, V17, P1625, DOI 10.7150/ijms.47103
   Yang SJ, 2023, J CLIN HYPERTENS, V25, P404, DOI 10.1111/jch.14661
   Zhang LC, 2024, J ANIM PHYSIOL AN N, V108, P921, DOI 10.1111/jpn.13941
   Zhang XY, 2024, SCI REP-UK, V14, DOI 10.1038/s41598-024-60172-w
NR 61
TC 2
Z9 2
U1 1
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2024
VL 16
IS 13
AR 2121
DI 10.3390/nu16132121
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA YN6V9
UT WOS:001269215900001
PM 38999869
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sodhi, K
   Puri, N
   Favero, G
   Stevens, S
   Meadows, C
   Abraham, NG
   Rezzani, R
   Ansinelli, H
   Lebovics, E
   Shapiro, JI
AF Sodhi, Komal
   Puri, Nitin
   Favero, Gaia
   Stevens, Sarah
   Meadows, Charles
   Abraham, Nader G.
   Rezzani, Rita
   Ansinelli, Hayden
   Lebovics, Edward
   Shapiro, Joseph I.
TI RETRACTED: Fructose Mediated Non-Alcoholic Fatty Liver Is Attenuated by
   HO-1-SIRT1 Module in Murine Hepatocytes and Mice Fed a High Fructose
   Diet (Retracted Article)
SO PLOS ONE
LA English
DT Article; Retracted Publication
ID IMPROVES INSULIN SENSITIVITY; MESENCHYMAL STEM-CELLS; HEPATIC STELLATE
   CELLS; HEME OXYGENASE; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   VASCULAR DYSFUNCTION; LIPID-PEROXIDATION; PROTECTIVE ROLE;
   ADIPOSE-TISSUE
AB Background
   Oxidative stress underlies the etiopathogenesis of nonalcoholic fatty liver disease (NAFLD), obesity and cardiovascular disease (CVD). Heme Oxygenase-1 (HO-1) is a potent endogenous antioxidant gene that plays a key role in decreasing oxidative stress. Sirtuin1 (SIRT1) belongs to the family of NAD-dependent de-acyetylases and is modulated by cellular redox.
   Hypothesis
   We hypothesize that fructose-induced obesity creates an inflammatory and oxidative environment conducive to the development of NAFLD and metabolic syndrome. The aim of this study is to determine whether HO-1 acts through SIRT1 to form a functional module within hepatocytes to attenuate steatohepatitis, hepatic fibrosis and cardiovascular dysfunction.
   Methods and Results
   We examined the effect of fructose, on hepatocyte lipid accumulation and fibrosis in murine hepatocytes and in mice fed a high fructose diet in the presence and absence of CoPP, an inducer of HO-1, and SnMP, an inhibitor of HO activity. Fructose increased oxidative stress markers and decreased HO-1 and SIRT1 levels in hepatocytes (p<0.05). Further fructose supplementation increased FAS, PPARa, pAMPK and triglycerides levels; CoPP negated this increase. Concurrent treatment with CoPP and SIRT1 siRNA in hepatocytes increased FAS, PPARa, pAMPK and triglycerides levels suggesting that HO-1 is upstream of SIRT1 and suppression of SIRT1 attenuates the beneficial effects of HO-1. A high fructose diet increased insulin resistance, blood pressure, markers of oxidative stress and lipogenesis along with fibrotic markers in mice (p<0.05). Increased levels of HO-1 increased SIRT1 levels and ameliorated fructose-mediated lipid accumulation and fibrosis in liver along with decreasing vascular dysfunction (p<0.05 vs. fructose). These beneficial effects of CoPP were reversed by SnMP.
   Conclusion
   Taken together, our study demonstrates, for the first time, that HO-1 induction attenuates fructose-induced hepatic lipid deposition, prevents the development of hepatic fibrosis and abates NAFLD-associated vascular dysfunction; effects that are mediated by activation of SIRT1 gene expression.
C1 [Sodhi, Komal; Stevens, Sarah; Meadows, Charles; Ansinelli, Hayden; Shapiro, Joseph I.] Marshall Univ, Joan C Edwards Sch Med, Dept Med, Huntington, WV 25701 USA.
   [Sodhi, Komal; Stevens, Sarah; Meadows, Charles; Ansinelli, Hayden; Shapiro, Joseph I.] Marshall Univ, Joan C Edwards Sch Med, Dept Surg, Huntington, WV USA.
   [Puri, Nitin] Univ Toledo, Coll Med, Dept Physiol & Pharmacol, Toledo, OH 43606 USA.
   [Favero, Gaia; Rezzani, Rita] Univ Brescia, Dept Clin & Expt Sci, Div Anat & Physiopathol, Brescia, Italy.
   [Abraham, Nader G.; Lebovics, Edward] New York Med Coll, Dept Med, Valhalla, NY 10595 USA.
   [Abraham, Nader G.; Lebovics, Edward] New York Med Coll, Dept Gastroenterol, Valhalla, NY 10595 USA.
C3 Marshall University; Marshall University; University System of Ohio;
   University of Toledo; University of Brescia; New York Medical College;
   New York Medical College
RP Sodhi, K (corresponding author), Marshall Univ, Joan C Edwards Sch Med, Dept Med, Huntington, WV 25701 USA.
EM Sodhi@marshall.edu
FU National Institutes of Health [NIH-1RO1HL109015-01]; Marshall University
FX Dr. Shapiro provided the funds to accomplish this study. Funds were
   taken from National Institutes of Health grant NIH-1RO1HL109015-01. The
   funding institution was Marshall University. Author who received funding
   is JS.
CR Abdelmalek MF, 2012, HEPATOLOGY, V56, P952, DOI 10.1002/hep.25741
   Abdelmalek MF, 2010, HEPATOLOGY, V51, P1961, DOI 10.1002/hep.23535
   Abraham NG, 2008, CURR PHARM DESIGN, V14, P412, DOI 10.2174/138161208783597371
   Abraham NG, 2008, PHARMACOL REV, V60, P79, DOI 10.1124/pr.107.07104
   ABRAHAM NG, 1986, BIOCHIM BIOPHYS ACTA, V870, P339, DOI 10.1016/0167-4838(86)90238-4
   Abraham NG, 2014, HYPERTENSION
   Adams LA, 2005, DIABETIC MED, V22, P1129, DOI 10.1111/j.1464-5491.2005.01748.x
   Adams LA, 2009, AM J GASTROENTEROL, V104, P861, DOI 10.1038/ajg.2009.67
   Armutcu F, 2005, CLIN BIOCHEM, V38, P540, DOI 10.1016/j.clinbiochem.2005.01.013
   Basaranoglu M, 2013, WORLD J GASTROENTERO, V19, P1166, DOI [10.3748/wig.v1918.1166, DOI 10.3748/96G3/19.18.1166]
   Berberat PO, 2003, FASEB J, V17, P1724, DOI 10.1096/fj.03-0229fje
   Botros FT, 2005, KIDNEY INT, V68, P2745, DOI 10.1111/j.1523-1755.2005.00745.x
   Bugianesi E, 2010, CURR PHARM DESIGN, V16, P1941, DOI 10.2174/138161210791208875
   Burgess A, 2010, HYPERTENSION, V56, P1124, DOI 10.1161/HYPERTENSIONAHA.110.151423
   Cao J, 2012, HYPERTENSION, V60, P467, DOI 10.1161/HYPERTENSIONAHA.112.193805
   Cao J, 2011, DIABETOL METAB SYNDR, V3, DOI 10.1186/1758-5996-3-37
   Cao JA, 2011, HUM GENE THER, V22, P271, DOI 10.1089/hum.2010.059
   Chau MDL, 2010, P NATL ACAD SCI USA, V107, P12553, DOI 10.1073/pnas.1006962107
   Chung SW, 2010, ARCH BIOCHEM BIOPHYS, V501, P79, DOI 10.1016/j.abb.2010.05.003
   DASILVA JL, 1994, AM J MED SCI, V307, P173, DOI 10.1097/00000441-199403000-00003
   Delgado JS, 2008, EUR J INTERN MED, V19, P75, DOI 10.1016/j.ejim.2007.02.034
   Elliott SS, 2002, AM J CLIN NUTR, V76, P911, DOI 10.1093/ajcn/76.5.911
   Estall JL, 2009, P NATL ACAD SCI USA, V106, P22510, DOI 10.1073/pnas.0912533106
   Gaggini M, 2013, NUTRIENTS, V5, P1544, DOI 10.3390/nu5051544
   García-Galiano D, 2007, OBES SURG, V17, P493, DOI 10.1007/s11695-007-9087-1
   Higdon AN, 2012, AM J PHYSIOL-HEART C, V302, pH1394, DOI 10.1152/ajpheart.00584.2011
   Hinds Jr T.D., 2013, OBESITY SILVER SPRIN
   Jiang JX, 2013, HEPATOLOGY, V58, P1339, DOI 10.1002/hep.26491
   Johnson RJ, 2009, ENDOCR REV, V30, P96, DOI 10.1210/er.2008-0033
   Kato J, 2003, ALCOHOL CLIN EXP RES, V27, p58S, DOI 10.1097/01.ALC.0000078614.44983.97
   Khitan Z, 2014, J NUTR METAB, V2014, DOI 10.1155/2014/980547
   Kim DH, 2008, J PHARMACOL EXP THER, V325, P833, DOI 10.1124/jpet.107.135285
   Kim E, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/290104
   Krähenbühl L, 2003, LIVER INT, V23, P101, DOI 10.1034/j.1600-0676.2003.00805.x
   Lazo M, 2013, AM J EPIDEMIOL, V178, P38, DOI 10.1093/aje/kws448
   Li M, 2008, DIABETES, V57, P1526, DOI 10.2337/db07-1764
   Li QH, 2009, CIRCULATION, V120, P1222, DOI 10.1161/CIRCULATIONAHA.108.778688
   Lim JS, 2010, NAT REV GASTRO HEPAT, V7, P251, DOI 10.1038/nrgastro.2010.41
   Longato L, 2013, FIBROGENESIS TISSUE, V6, DOI 10.1186/1755-1536-6-14
   Marchesini G, 2003, HEPATOLOGY, V37, P917, DOI 10.1053/jhep.2003.50161
   McCullough AJ, 2006, J CLIN GASTROENTEROL, V40, pS17
   Nicolai A, 2009, HYPERTENSION, V53, P508, DOI 10.1161/HYPERTENSIONAHA.108.124701
   Nomura K, 2012, J NUTR BIOCHEM, V23, P203, DOI 10.1016/j.jnutbio.2011.09.006
   Oni ET, 2013, ATHEROSCLEROSIS, V230, P258, DOI 10.1016/j.atherosclerosis.2013.07.052
   Peterson SJ, 2009, J LIPID RES, V50, P1293, DOI 10.1194/jlr.M800610-JLR200
   Pettinelli P, 2011, NUTR HOSP, V26, P441, DOI [10.1590/S0212-16112011000300003, 10.3305/nh.2011.26.3.5119]
   Puri N, 2012, J CELL BIOCHEM, V113, P1926, DOI 10.1002/jcb.24061
   Purushotham A, 2009, CELL METAB, V9, P327, DOI 10.1016/j.cmet.2009.02.006
   Qureshi K, 2007, WORLD J GASTROENTERO, V13, P3540, DOI 10.3748/wjg.v13.i26.3540
   Rebollo A, 2012, WORLD J GASTROENTERO, V18, P6552, DOI 10.3748(wig.v18145.6552
   Sodhi K, 2012, PROSTAG OTH LIPID M, V98, P133, DOI 10.1016/j.prostaglandins.2011.12.004
   Stienstra R, 2007, ENDOCRINOLOGY, V148, P2753, DOI 10.1210/en.2007-0014
   Tacer KF, 2011, J LIPIDS, V2011, DOI 10.1155/2011/783976
   Targher G, 2007, DIABETIC MED, V24, P1, DOI 10.1111/j.1464-5491.2007.02025.x
   Targher G, 2007, ATHEROSCLEROSIS, V191, P235, DOI 10.1016/j.atherosclerosis.2006.08.021
   Targher G, 2013, J CLIN ENDOCR METAB, V98, P483, DOI 10.1210/jc.2012-3093
   Tatjana Abel, 2008, Orvosi Hetilap, V149, P1299, DOI 10.1556/OH.2008.28418
   Théret N, 1999, HEPATOLOGY, V30, P462, DOI 10.1002/hep.510300236
   Vasko R., 2013, J Am Soc Nephrol
   Vernon G, 2011, ALIMENT PHARM THER, V34, P274, DOI 10.1111/j.1365-2036.2011.04724.x
   Williams CD, 2011, GASTROENTEROLOGY, V140, P124, DOI 10.1053/j.gastro.2010.09.038
   Xirouchakis E, 2008, CURR PHARM DESIGN, V14, P378
   Yamazaki Y, 2009, AM J PHYSIOL-ENDOC M, V297, pE1179, DOI 10.1152/ajpendo.90997.2008
   Yang H, 2012, WORLD J GASTROENTERO, V18, P1680, DOI 10.3748/wjg.v18.i14.1680
NR 64
TC 61
Z9 63
U1 0
U2 18
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 22
PY 2015
VL 10
IS 6
AR e0128648
DI 10.1371/journal.pone.0128648
PG 22
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CL3FM
UT WOS:000356835800018
PM 26098879
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Su, Y
   Yu, H
   Wang, ZR
   Liu, S
   Zhao, LS
   Fu, YM
   Yang, YF
   Du, B
   Zhang, FQ
   Zhang, XR
   Huang, ML
   Hou, CL
   Huang, GP
   Su, ZH
   Peng, M
   Yan, R
   Zhang, YY
   Yan, H
   Wang, LF
   Lu, TL
   Jia, FJ
   Li, KQ
   Lv, LX
   Wang, HX
   Yu, SY
   Wang, Q
   Tan, YL
   Xu, Y
   Zhang, D
   Yue, WH
AF Su, Yi
   Yu, Hao
   Wang, Zhiren
   Liu, Sha
   Zhao, Liansheng
   Fu, Yingmei
   Yang, Yongfeng
   Du, Bo
   Zhang, Fuquan
   Zhang, Xiangrong
   Huang, Manli
   Hou, Cailan
   Huang, Guoping
   Su, Zhonghua
   Peng, Mao
   Yan, Ran
   Zhang, Yuyanan
   Yan, Hao
   Wang, Lifang
   Lu, Tianlan
   Jia, Fujun
   Li, Keqing
   Lv, Luxian
   Wang, Hongxing
   Yu, Shunying
   Wang, Qiang
   Tan, Yunlong
   Xu, Yong
   Zhang, Dai
   Yue, Weihua
TI Protocol for a pharmacogenomic study on individualised antipsychotic
   drug treatment for patients with schizophrenia
SO BJPSYCH OPEN
LA English
DT Article
DE Antipsychotics; clinical trial; schizophrenia; drug interactions and
   side-effects; genetics
ID RATING-SCALE; ASSOCIATION; CLOZAPINE; POLYMORPHISMS; DEFINITION;
   CONCORDANT; ABCB1
AB Background Schizophrenia is a severe and complex psychiatric disorder that needs treatment based on extensive experience. Antipsychotic drugs have already become the cornerstone of the treatment for schizophrenia; however, the therapeutic effect is of significant variability among patients, and only around a third of patients with schizophrenia show good efficacy. Meanwhile, drug-induced metabolic syndrome and other side-effects significantly affect treatment adherence and prognosis. Therefore, strategies for drug selection are desperately needed. In this study, we will perform pharmacogenomics research and set up an individualised preferred treatment prediction model. Aims We aim to create a standard clinical cohort, with multidimensional index assessment of antipsychotic treatment for patients with schizophrenia. Method This trial is designed as a randomised clinical trial comparing treatment with different kinds of antipsychotics. A total sample of 2000 patients with schizophrenia will be recruited from in-patient units from five clinical research centres. Using a computer-generated program, the participants will be randomly assigned to four treatment groups: aripiprazole, olanzapine, quetiapine and risperidone. The primary outcomes will be measured as changes in the Positive and Negative Syndrome Scale of schizophrenia, which reflects the efficacy. Secondary outcomes include the measure of side-effects, such as metabolic syndromes. The efficacy evaluation and side-effects assessment will be performed at baseline, 2 weeks, 6 weeks and 3 months. Results This trial will assess the efficacy and side effects of antipsychotics and create a standard clinical cohort with a multi-dimensional index assessment of antipsychotic treatment for schizophrenia patients. Conclusion This study aims to set up an individualized preferred treatment prediction model through the genetic analysis of patients using different kinds of antipsychotics.
C1 [Su, Yi; Yu, Hao; Zhang, Yuyanan; Yan, Hao; Wang, Lifang; Lu, Tianlan; Zhang, Dai; Yue, Weihua] Peking Univ, Inst Mental Hlth, Hosp 6, Beijing, Peoples R China.
   [Su, Yi; Yu, Hao; Zhang, Yuyanan; Yan, Hao; Wang, Lifang; Lu, Tianlan; Zhang, Dai; Yue, Weihua] Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing, Peoples R China.
   [Su, Yi; Yu, Hao; Zhang, Yuyanan; Yan, Hao; Wang, Lifang; Lu, Tianlan; Zhang, Dai; Yue, Weihua] Peking Univ, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China.
   [Yu, Hao] Jining Med Univ, Dept Psychiat, Jining, Peoples R China.
   [Wang, Zhiren] Peking Univ, Beijing HuiLongGuan Hosp, Psychiat Res Ctr, Beijing, Peoples R China.
   [Liu, Sha; Xu, Yong] Shanxi Med Univ, Dept Psychiat, Hosp 1, Clin Med Coll 1, Taiyuan, Peoples R China.
   [Zhao, Liansheng; Wang, Qiang] Sichuan Univ, West China Hosp, Mental Hlth Ctr, Chengdu, Peoples R China.
   [Fu, Yingmei; Yu, Shunying] Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Shanghai, Peoples R China.
   [Yang, Yongfeng; Lv, Luxian] Xinxiang Med Univ, Henan Mental Hosp, Affiliated Hosp 2, Xinxiang, Henan, Peoples R China.
   [Du, Bo; Li, Keqing] Sixth Peoples Hosp Hebei Prov, Hebei Mental Hlth Ctr, Baoding, Peoples R China.
   [Zhang, Fuquan] Nanjing Med Univ, Wuxi Mental Hlth Ctr, Nanjing, Peoples R China.
   [Zhang, Xiangrong] Nanjing Med Univ, Nanjing Brain Hosp, Dept Geriatr Psychiat, Nanjing, Peoples R China.
   [Huang, Manli] Zhejiang Univ, Sch Med, Dept Psychiat, Affiliated Hosp 1, Hangzhou, Peoples R China.
   [Huang, Manli] Key Lab Mental Disorders Management Zhejiang Prov, Hangzhou, Peoples R China.
   [Hou, Cailan] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Mental Hlth Ctr, Guangzhou, Guangdong, Peoples R China.
   [Hou, Cailan; Jia, Fujun] South China Univ Technol, Sch Med, Guangzhou, Guangdong, Peoples R China.
   [Huang, Guoping] Mental Hlth Ctr Sichuan Prov, Dept Psychiat, Chengdu, Peoples R China.
   [Su, Zhonghua] Jining Mental Hosp, Dept Psychiat, Jining, Peoples R China.
   [Peng, Mao; Wang, Hongxing] Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China.
   [Yan, Ran] Minist Hlth PRC, Dept Radiol, China Japan Friendship Hosp, Beijing, Peoples R China.
   [Jia, Fujun] Guangdong Gen Hosp, Guangdong Mental Hlth Ctr, Guangzhou, Peoples R China.
   [Tan, Yunlong] Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing, Peoples R China.
   [Zhang, Dai] Peking Univ, Peking Tsinghua Joint Ctr Life Sci, IDG McGovern Inst Brain Res, Beijing, Peoples R China.
C3 Peking University; Peking University; Peking University; Jining Medical
   University; Peking University; Shanxi Medical University; Sichuan
   University; Shanghai Jiao Tong University; Xinxiang Medical University;
   Nanjing Medical University; Nanjing Medical University; Zhejiang
   University; Guangdong Academy of Medical Sciences & Guangdong General
   Hospital; Southern Medical University - China; South China University of
   Technology; Capital Medical University; China-Japan Friendship Hospital;
   Guangdong Academy of Medical Sciences & Guangdong General Hospital;
   Peking University; Peking University
RP Yue, WH (corresponding author), Peking Univ, Inst Mental Hlth, Hosp 6, Beijing, Peoples R China.; Yue, WH (corresponding author), Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing, Peoples R China.; Yue, WH (corresponding author), Peking Univ, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China.
EM dryue@bjmu.edu.cn
RI , 复之-王红星/ABF-3671-2020; meng, yan/GSE-2653-2022; Zhang,
   Yuyanan/ISR-9977-2023; Zhang, Fengyu/M-1396-2019; Yang,
   Yongfeng/I-7680-2016; She, Zhi-Gang/AFP-9194-2022; Fu,
   Yingmei/AAN-1675-2021; Liu, Feng-Liang/O-4000-2019; qianglong,
   wang/HIK-3742-2022; Yu, Hao/GYD-8698-2022; Zhang, Deng-Feng/K-1125-2015;
   Yan, Hao/U-1330-2017; Su, Yi/ISU-4977-2023
OI Yu, Hao/0000-0002-9785-8489; Zhang, Fuquan/0000-0003-3204-8191; Su,
   Yi/0000-0003-0067-7313
FU Chinese Ministry of Science and Technology [2016YFC1307000]
FX This work is supported by a grant to Weihua Yue on behalf of the whole
   projectfrom the Chinese Ministry of Science and Technology (grant number
   2016YFC1307000).
CR Åberg K, 2010, BIOL PSYCHIAT, V67, P279, DOI 10.1016/j.biopsych.2009.08.036
   Adkins DE, 2011, MOL PSYCHIATR, V16, P321, DOI 10.1038/mp.2010.14
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   ARRANZ M, 1995, LANCET, V346, P281, DOI 10.1016/S0140-6736(95)92168-0
   BARNES TRE, 1989, BRIT J PSYCHIAT, V154, P672, DOI 10.1192/bjp.154.5.672
   Busner Joan, 2007, Psychiatry (Edgmont), V4, P28
   Clark SL, 2013, PHARMACOGENET GENOM, V23, P69, DOI 10.1097/FPC.0b013e32835ca260
   Consoli G, 2009, PHARMACOGENOMICS, V10, P1267, DOI 10.2217/PGS.09.51
   Delaneau O, 2013, NAT METHODS, V10, P5, DOI 10.1038/nmeth.2307
   First MB., 1997, Structured Clinical Interview for DSM-IV Axis I Disorders-Clinican Version (SCID-CV)
   Guy W., 1976, ECDEU Assessment Manual for Psychopharmacology, V76, P217
   Horácek J, 2001, INT J PSYCHIAT CLIN, V5, P71, DOI 10.1080/136515001300225231
   Howie BN, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000529
   Huber CG, 2008, EXPERT OPIN PHARMACO, V9, P2027, DOI [10.1517/14656566.9.12.2027, 10.1517/14656566.9.12.2027 ]
   Hwang R, 2010, PHARMACOGENOMICS J, V10, P200, DOI 10.1038/tpj.2009.65
   Ilyas S, 2012, BRIT J PSYCHIAT, V200, P393, DOI 10.1192/bjp.bp.111.104257
   Jones PB, 2006, ARCH GEN PSYCHIAT, V63, P1079, DOI 10.1001/archpsyc.63.10.1079
   KAY SR, 1987, SCHIZOPHRENIA BULL, V13, P261, DOI 10.1093/schbul/13.2.261
   Lencz T, 2006, AM J PSYCHIAT, V163, P529, DOI 10.1176/appi.ajp.163.3.529
   Lichtenstein P, 2009, LANCET, V373, P234, DOI 10.1016/S0140-6736(09)60072-6
   Lieberman JA, 2007, J CLIN PSYCHIAT, V68, P151, DOI 10.4088/JCP.v68n0120
   Malhotra AK, 2004, AM J PSYCHIAT, V161, P780, DOI 10.1176/appi.ajp.161.5.780
   McClay JL, 2011, MOL PSYCHIATR, V16, P76, DOI 10.1038/mp.2009.89
   McClay JL, 2011, NEUROPSYCHOPHARMACOL, V36, P616, DOI 10.1038/npp.2010.193
   MUNETZ MR, 1988, HOSP COMMUNITY PSYCH, V39, P1172
   Price AL, 2006, NAT GENET, V38, P904, DOI 10.1038/ng1847
   Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795
   Ravyn D, 2013, SCHIZOPHR RES, V149, P1, DOI 10.1016/j.schres.2013.06.035
   Reynolds GP, 2005, PROG NEURO-PSYCHOPH, V29, P1021, DOI 10.1016/j.pnpbp.2005.03.019
   SIMPSON GM, 1970, ACTA PSYCHIAT SCAND, P11
   Sirot EJ, 2009, J CLIN PSYCHOPHARM, V29, P319, DOI 10.1097/JCP.0b013e3181acc372
   Thaker GK, 2001, NAT MED, V7, P667, DOI 10.1038/89040
   Wehmeier PM, 2005, PSYCHIAT RES, V133, P273, DOI 10.1016/j.psychres.2004.02.018
   Zhang JP, 2010, AM J PSYCHIAT, V167, P763, DOI 10.1176/appi.ajp.2009.09040598
NR 34
TC 6
Z9 6
U1 1
U2 12
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2056-4724
J9 BJPSYCH OPEN
JI BJPsych Open
PD JUN 29
PY 2021
VL 7
IS 4
AR e121
DI 10.1192/bjo.2021.945
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA TB1JH
UT WOS:000667698900001
PM 34183088
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Che, LQ
   Xuan, Y
   Hu, L
   Liu, Y
   Xu, Q
   Fang, ZF
   Lin, Y
   Xu, SY
   Wu, D
   Zhang, KY
   Chen, DW
AF Che, Lianqiang
   Xuan, Yue
   Hu, Liang
   Liu, Yan
   Xu, Qin
   Fang, Zhengfeng
   Lin, Yan
   Xu, Shengyu
   Wu, De
   Zhang, Keying
   Chen, Daiwen
TI Effect of Postnatal Nutrition Restriction on the Oxidative Status of
   Neonates with Intrauterine Growth Restriction in a Pig Model
SO NEONATOLOGY
LA English
DT Article
DE Intrauterine growth restriction; Postnatal nutrition restriction;
   Oxidative stress
ID CATCH-UP GROWTH; METABOLIC SYNDROME; FREE-RADICALS; GLUCOSE-INTOLERANCE;
   CALORIE RESTRICTION; DEFENSE CAPACITY; STRESS MARKERS; HIGH-FAT;
   OBESITY; RATS
AB Objective: In offspring with intrauterine growth restriction (IUGR), where oxidative stress may play an important role in inducing metabolic syndrome, nutrition restriction has been shown to improve oxidative status. In this study, we aimed to investigate the effect of postnatal nutrition restriction on the oxidative status of IUGR neonates. Methods: A total of twelve pairs of piglets, of normal birth-weight (NBW) and with IUGR (7 days old), respectively, were randomly allocated to have adequate nutritional intake (ANI) and restricted nutritional intake (RNI) for a period of 21 days, respectively. This design produced 4 experimental groups: NBW-ANI, IUGR-ANI, NBW-RNI and IUGR-RNI (n = 6 per group). Serum, ileum and liver samples were analyzed for antioxidant parameters and the mRNA expression of genes with regard to oxidative status. The data were subjected to general linear model analysis and Duncan's test with a 5% significance level. Results: Irrespective of nutritional intake, the IUGR pigs had markedly lower activity of glutathione peroxidase (GP(x)), gene expressions of liver mitochondrial manganese superoxide dismutase (Mn-SOD) and ileum cytoplasmic copper/zinc (CuZn)-SOD and, accordingly, there was a markedly higher malondialdehyde concentration in the liver of these pigs compared to in the NBW pigs. Irrespective of body weight, pigs receiving ANI treatment had significantly lower activities of antioxidant enzymes in the serum (total antioxidative capability, CuZn-SOD and GP(x)) and liver (total SOD and glutathione reductase) and decreased gene expression of liver CuZn-SOD and Mn-SOD compared to the pig's receiving RNI. In addition, the IUGR pigs had a markedly lower concentration of liver reduced glutathione (GSH), ratio of GSH to oxidized glutathione, gene expression of ileum CuZn-SOD and extracellular SOD than the NBW pigs when receiving ANI, but not all of these differences were observed in those receiving RNI. Conclusion: IUGR neonates may have poor antioxidant defense systems, and postnatal nutrition restriction has the potential to prevent oxidative stress. (C) 2014 S. Karger AG, Basel
C1 [Che, Lianqiang; Xuan, Yue; Hu, Liang; Liu, Yan; Xu, Qin; Fang, Zhengfeng; Lin, Yan; Xu, Shengyu; Wu, De; Zhang, Keying; Chen, Daiwen] Sichuan Agr Univ, Key Lab Anim Dis Resistant Nutr, Inst Anim Nutr, Minist Educ, Chengdu 611130, Sichuan, Peoples R China.
C3 Ministry of Education - China; Sichuan Agricultural University
RP Che, LQ (corresponding author), Sichuan Agr Univ, Key Lab Anim Dis Resistant Nutr, Inst Anim Nutr, Minist Educ, 211 Huimin Rd, Chengdu 611130, Sichuan, Peoples R China.
EM clianqiang@hotmail.com
RI Xu, Shengyu/AFN-8288-2022; Zhang, Keying/AAG-5912-2020
OI Wu, De/0000-0003-1873-9914
FU National Natural Science Foundation, PR China [31101727]
FX This work was supported by the National Natural Science Foundation (No.
   31101727), PR China.
CR [Anonymous], 2012, COCHRANE DATABASE SY
   Aruoma OI, 1998, J AM OIL CHEM SOC, V75, P199, DOI 10.1007/s11746-998-0032-9
   Berends LM, 2013, INT J OBESITY, V37, P1051, DOI 10.1038/ijo.2012.196
   Che LQ, 2010, PEDIATR RES, V67, P54, DOI 10.1203/PDR.0b013e3181c1b15e
   Claris O, 2010, SEMIN PERINATOL, V34, P207, DOI 10.1053/j.semperi.2010.02.005
   Dai Y, 2012, ENDOCRINOLOGY, V153, P4216, DOI 10.1210/en.2012-1206
   Décorde K, 2009, MOL NUTR FOOD RES, V53, P659, DOI 10.1002/mnfr.200800165
   Dennery PA, 2010, FREE RADICAL BIO MED, V49, P1147, DOI 10.1016/j.freeradbiomed.2010.07.011
   Desai M, 2005, AM J PHYSIOL-REG I, V288, pR91, DOI 10.1152/ajpregu.00340.2004
   Devaraj S, 2008, METABOLISM, V57, P867, DOI 10.1016/j.metabol.2008.02.016
   Dröge W, 2002, PHYSIOL REV, V82, P47, DOI 10.1152/physrev.00018.2001
   Feillet-Coudray C, 2009, FREE RADICAL BIO MED, V46, P624, DOI 10.1016/j.freeradbiomed.2008.11.020
   Garg M, 2013, ENDOCRINOLOGY, V154, P102, DOI 10.1210/en.2012-1640
   Garg M, 2012, DIABETES, V61, P1391, DOI 10.2337/db11-1347
   Han F, 2013, BRIT J NUTR, V110, P1819, DOI 10.1017/S0007114513001232
   Hracsko Z, 2008, REDOX REP, V13, P11, DOI 10.1179/135100008X259097
   Humphray SJ, 2007, GENOME BIOL, V8, DOI 10.1186/gb-2007-8-7-r139
   Jia J, 2009, FOOD CHEM, V115, P32, DOI 10.1016/j.foodchem.2008.11.043
   Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
   Luo ZC, 2006, MED HYPOTHESES, V66, P38, DOI 10.1016/j.mehy.2005.08.020
   McMillen IC, 2005, PHYSIOL REV, V85, P571, DOI 10.1152/physrev.00053.2003
   MORON MS, 1979, BIOCHIM BIOPHYS ACTA, V582, P67, DOI 10.1016/0304-4165(79)90289-7
   Pineda-Caplliure A, 2013, J PEDIATR BIOCHEM, V3, P137, DOI 10.3233/JPB-130086
   Rinaudo P, 2012, ANNU REV PHYSIOL, V74, P107, DOI 10.1146/annurev-physiol-020911-153245
   Shahkhalili Y, 2010, AM J PHYSIOL-REG I, V298, pR141, DOI 10.1152/ajpregu.00128.2009
   Singhal A, 2007, CIRCULATION, V115, P213, DOI 10.1161/CIRCULATIONAHA.106.617811
   Taguchi K, 2014, BIOL PHARM BULL, V37, P1056, DOI 10.1248/bpb.b14-00157
   Tarry-Adkins JL, 2013, FASEB J, V27, P379, DOI 10.1096/fj.12-218685
   Tarry-Adkins JL, 2010, FASEB J, V24, P2762, DOI 10.1096/fj.10-156075
   Valko M, 2007, INT J BIOCHEM CELL B, V39, P44, DOI 10.1016/j.biocel.2006.07.001
   Wang JJ, 2012, ANTIOXID REDOX SIGN, V17, P282, DOI 10.1089/ars.2011.4381
   Wu G, 2006, J ANIM SCI, V84, P2316, DOI 10.2527/jas.2006-156
   Ye H, 2009, EUR FOOD RES TECHNOL, V230, P101, DOI 10.1007/s00217-009-1147-4
NR 33
TC 27
Z9 32
U1 1
U2 19
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1661-7800
EI 1661-7819
J9 NEONATOLOGY
JI Neonatology
PY 2015
VL 107
IS 2
BP 93
EP 99
DI 10.1159/000368179
PG 7
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA CB5IG
UT WOS:000349660100003
PM 25412706
DA 2025-06-11
ER

PT J
AU Monti, LD
   Galluccio, E
   Villa, V
   Fontana, B
   Spadoni, S
   Piatti, PM
AF Monti, Lucilla D.
   Galluccio, Elena
   Villa, Valentina
   Fontana, Barbara
   Spadoni, Serena
   Piatti, Pier Marco
TI Decreased diabetes risk over 9 year after 18-month oral L-arginine
   treatment in middle-aged subjects with impaired glucose tolerance and
   metabolic syndrome (extension evaluation of L-arginine study)
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE L-Arginine; Endothelial function; Insulin secretion; Prevention of type
   2 diabetes; Oxidative stress
ID ENDOTHELIAL PROGENITOR CELLS; 10-YEAR FOLLOW-UP; INSULIN SENSITIVITY;
   ASYMMETRIC DIMETHYLARGININE; CARDIOVASCULAR-DISEASE; BETA-CELLS;
   SUPPLEMENTATION; DYSFUNCTION; RESISTANCE; SECRETION
AB Purpose This study aimed to determine whether L-arginine supplementation lasting for 18 months maintained longlasting effects on diabetes incidence, insulin secretion and sensitivity, oxidative stress, and endothelial function during 108 months among subjects at high risk of developing type 2 diabetes.
   Methods One hundred and forty-four middle-aged subjects with impaired glucose tolerance and metabolic syndrome were randomized in 2006 to an L-arginine supplementation (6.4 g orally/day) or placebo therapy lasting 18 months. This period was followed by a 90-month follow-up. The primary outcome was a diagnosis of diabetes during the 108 month study period. Secondary outcomes included changes in insulin secretion (proinsulin/c-peptide ratio), insulin sensitivity (IGI/HOMA-IR), oxidative stress (AOPPs), and vascular function. After the 18 month participation, subjects that were still free of diabetes and willing to continue their participation (104 subjects) were further followed until diabetes diagnosis, with a time span of about 9 years from baseline.
   Results Although results derived from the 18 month of the intervention study demonstrated no differences in the probability of becoming diabetics, at the end of the study, the cumulative incidence of diabetes was of 40.6% in the L-arginine group and of 57.4% in the placebo group. The adjusted HR for diabetes (L-arginine vs. placebo) was 0.66; 95% CI 0.48, 0.91; p < 0.02). Proinsulin/c-peptide ratio (p < 0.001), IGI/HOMA-IR (p < 0.01), and AOPP (p < 0.05) levels were ameliorated in L-arginine compared to placebo.
   Conclusions These results may suggest that the administration of L-arginine could delay the development of T2DM for a long period. This effect could be mediated, in some extent, by L-arginine-induced reduction in oxidative stress.
C1 [Monti, Lucilla D.; Galluccio, Elena; Fontana, Barbara; Spadoni, Serena] Ist Sci San Raffaele, Diabet Res Inst, Cardiodiabet & Core Lab Unit, Dept Internal Med, Via Olgettina 60, I-20132 Milan, Italy.
   [Villa, Valentina; Piatti, Pier Marco] Ist Sci San Raffaele, Diabet Res Inst, Dept Internal Med, Cardiometab & Clin Trials Unit, Milan, Italy.
C3 Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele;
   Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele
RP Monti, LD (corresponding author), Ist Sci San Raffaele, Diabet Res Inst, Cardiodiabet & Core Lab Unit, Dept Internal Med, Via Olgettina 60, I-20132 Milan, Italy.
EM monti.lucilla@hsr.it
RI Galluccio, Elena/GQQ-1903-2022; Monti, Lucilla/AAN-3716-2020; Piatti,
   Piermarco/AAN-3115-2020
FU Italian Ministry of Health [88]
FX Funding Italian Ministry of Health, Finalizzata no. 88, 2004.
CR Araujo TR, 2017, EUR J NUTR, V56, P2069, DOI 10.1007/s00394-016-1245-6
   Awad O, 2005, STEM CELLS, V23, P575, DOI 10.1634/stemcells.2004-0185
   Böger RH, 2007, J NUTR, V137, p1650S, DOI 10.1093/jn/137.6.1650S
   Bosch J, 2006, NEW ENGL J MED, V355, P1551
   Bray GA, 2009, LANCET, V374, P1677, DOI 10.1016/S0140-6736(09)61457-4
   Butler AE, 2003, DIABETES, V52, P102, DOI 10.2337/diabetes.52.1.102
   Cardounel AJ, 2007, J BIOL CHEM, V282, P879, DOI 10.1074/jbc.M603606200
   Chalmers J, 2008, NEW ENGL J MED, V359, P1618, DOI 10.1056/NEJMe0807625
   Cubbon RM, 2009, CLIN SCI, V117, P173, DOI 10.1042/CS20080263
   Diabet Control Complications DCCT Res Grp, 1995, KIDNEY INT, V47, P1703
   Fadini GP, 2007, DIABETOLOGIA, V50, P2156, DOI 10.1007/s00125-007-0732-y
   Fadini GP, 2005, J AM COLL CARDIOL, V45, P1449, DOI 10.1016/j.jacc.2004.11.067
   Ford ES, 2010, J AM COLL CARDIOL, V55, P1310, DOI 10.1016/j.jacc.2009.10.060
   Hanley AJ, 2010, DIABETES CARE, V33, P608, DOI 10.2337/dc09-1579
   Hill JM, 2003, NEW ENGL J MED, V348, P593, DOI 10.1056/NEJMoa022287
   Holman RR, 2008, NEW ENGL J MED, V359, P1577, DOI 10.1056/NEJMoa0806470
   Jensen CC, 2002, DIABETES, V51, P2170, DOI 10.2337/diabetes.51.7.2170
   Krause MS, 2011, J ENDOCRINOL, V211, P87, DOI 10.1530/JOE-11-0236
   Lass A, 2002, MOL PHARMACOL, V61, P1081, DOI 10.1124/mol.61.5.1081
   Li M, 2012, CELL PHYSIOL BIOCHEM, V30, P439, DOI 10.1159/000339037
   Liang M, 2017, LAB INVEST, V97, P792, DOI 10.1038/labinvest.2017.24
   Lucotti P, 2006, AM J PHYSIOL-ENDOC M, V291, pE906, DOI 10.1152/ajpendo.00002.2006
   Lucotti P, 2009, METABOLISM, V58, P1270, DOI 10.1016/j.metabol.2009.03.029
   Lyssenko V, 2005, DIABETES, V54, P166, DOI 10.2337/diabetes.54.1.166
   MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
   McCullough ML, 1999, J AM DIET ASSOC, V99, pS45, DOI 10.1016/S0002-8223(99)00416-2
   Méndez JD, 2005, BIOMED PHARMACOTHER, V59, P283, DOI 10.1016/j.biopha.2005.05.006
   Monti LD, 2012, DIABETES OBES METAB, V14, P893, DOI 10.1111/j.1463-1326.2012.01615.x
   Mykkanen L, 1997, DIABETES, V46, P1990, DOI 10.2337/diabetes.46.12.1990
   Nathan DM, 2007, DIABETIC MED, V24, P137
   Newsholme P, 2014, J ENDOCRINOL, V221, pR105, DOI 10.1530/JOE-13-0616
   Pan XR, 1997, DIABETES CARE, V20, P537, DOI 10.2337/diacare.20.4.537
   Pfutzner Andreas, 2004, Clin Lab, V50, P567
   Piatti P, 2001, DIABETES CARE, V24, P875, DOI 10.2337/diacare.24.5.875
   McLellan KCP, 2014, THER CLIN RISK MANAG, V10, P173, DOI 10.2147/TCRM.S39564
   Schernthaner G, 2008, BIOMARK MED, V2, P317, DOI 10.2217/17520363.2.4.317
   Shan LL, 2013, J APPL PHYSIOL, V115, P1146, DOI 10.1152/japplphysiol.00225.2013
   Shi XY, 2008, ENDOCRINOLOGY, V149, P1829, DOI 10.1210/en.2007-1544
   Surdacki A, 2013, CARDIOVASC DIABETOL, V12, DOI 10.1186/1475-2840-12-64
   Tepper OM, 2002, CIRCULATION, V106, P2781, DOI 10.1161/01.CIR.0000039526.42991.93
   Topolski Tari D, 2006, Prev Chronic Dis, V3, pA118
   Tuomilehto J, 2001, NEW ENGL J MED, V344, P1343, DOI 10.1056/NEJM200105033441801
   Vasilijevic A, 2007, J PHYSIOL-LONDON, V584, P921, DOI 10.1113/jphysiol.2007.140277
   VISEK WJ, 1986, J NUTR, V116, P36, DOI 10.1093/jn/116.1.36
   Wascher TC, 1997, EUR J CLIN INVEST, V27, P690, DOI 10.1046/j.1365-2362.1997.1730718.x
   Wells BJ, 2005, NUTRITION, V21, P125, DOI 10.1016/j.nut.2004.03.021
   Wilcox CS, 2012, HYPERTENSION, V59, P375, DOI 10.1161/HYPERTENSIONAHA.111.187310
   Wu GY, 2009, AMINO ACIDS, V37, P153, DOI 10.1007/s00726-008-0210-y
   Yue WS, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-113
   Zethelius B, 2004, DIABETES CARE, V27, P1433, DOI 10.2337/diacare.27.6.1433
NR 50
TC 32
Z9 32
U1 0
U2 4
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD DEC
PY 2018
VL 57
IS 8
BP 2805
EP 2817
DI 10.1007/s00394-017-1548-2
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HB1ZF
UT WOS:000450829600013
PM 29052766
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Tunapong, W
   Apaijai, N
   Yasom, S
   Tanajak, P
   Wanchai, K
   Chunchai, T
   Kerdphoo, S
   Eaimworawuthikul, S
   Thiennimitr, P
   Pongchaidecha, A
   Lungkaphin, A
   Pratchayasakul, W
   Chattipakorn, SC
   Chattipakorn, N
AF Tunapong, Wannipa
   Apaijai, Nattayaporn
   Yasom, Sakawdaurn
   Tanajak, Pongpan
   Wanchai, Keerati
   Chunchai, Titikorn
   Kerdphoo, Sasiwan
   Eaimworawuthikul, Sathima
   Thiennimitr, Parameth
   Pongchaidecha, Anchalee
   Lungkaphin, Anusorn
   Pratchayasakul, Wasana
   Chattipakorn, Siriporn C.
   Chattipakorn, Nipon
TI Chronic treatment with prebiotics, probiotics and synbiotics attenuated
   cardiac dysfunction by improving cardiac mitochondrial dysfunction in
   male obese insulin-resistant rats
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Prebiotics; Probiotics; Synbiotics; Obese insulin resistance; Cardiac
   mitochondria; Systemic inflammation
ID HEART-RATE-VARIABILITY; DIET-INDUCED OBESITY; DIPEPTIDYL PEPTIDASE-4
   INHIBITOR; GUT MICROBIOTA; OXIDATIVE STRESS; GLUCOSE-INTOLERANCE;
   METABOLIC SYNDROME; BLOOD-GLUCOSE; OLIGOFRUCTOSE; INFLAMMATION
AB Purpose In metabolic syndrome, the composition of gut microbiota has been disrupted, and is associated with left ventricular (LV) dysfunction. Several types of prebiotics, probiotics, and synbiotics have been shown to exert cardio-protection by restoring gut microbiota from dysbiosis and reducing systemic inflammation. However, the effects of prebiotics such as xylooligosaccharides (XOS); probiotics such as Lactobacillus paracasei STII01 HP4, and synbiotics on metabolic and LV function in obese insulin-resistant rats have not been investigated. In this study, we hypothesized that prebiotics and probiotics improve metabolic parameters, heart rate variability (HRV), blood pressure (BP), and LV function by attenuating cardiac mitochondrial dysfunction, systemic inflammation, and oxidative stress, and that synbiotics provide greater efficacy than a single regimen in obese insulin resistance.
   Methods Rats were fed with either normal diet or high-fat diet (HFD) for 12 weeks and then rats in each dietary group were randomly subdivided into four subgroups to receive either a vehicle, prebiotics, probiotics, or synbiotics for another 12 weeks. Metabolic parameters, BP, HRV, LV function, cardiac mitochondrial function, systemic inflammation, and oxidative stress were determined.
   Results HFD-fed rats had obese insulin resistance with markedly increased systemic inflammatory marker [Serum LPS; ND; 0.6 +/- 0.1 EU/ml vs. HFD; 5.7 +/- 1.2 EU/ml (p < 0.05)], depressed HRV, and increased BP and LV dysfunction [%ejection fraction; ND; 93 +/- 2% vs. HFD; 83 +/- 2% (p < 0.05)]. Prebiotics, probiotics, and synbiotics attenuated insulin resistance by improving insulin sensitivity and lipid profiles. All interventions also improved HRV, BP, LV function [%ejection fraction; HFV; 81 +/- 2% vs. HFPE; 93 +/- 3%, HFPO; 92 +/- 1%, HFC; 92 +/- 2% (p < 0.05)] by attenuating mitochondrial dysfunction, oxidative stress, and systemic inflammation in obese insulin-resistant rats.
   Conclusion Prebiotics, probiotics, and synbiotics shared similar efficacy in reducing insulin resistance and LV dysfunction in obese insulin-resistant rats.
C1 [Tunapong, Wannipa; Apaijai, Nattayaporn; Yasom, Sakawdaurn; Tanajak, Pongpan; Wanchai, Keerati; Chunchai, Titikorn; Kerdphoo, Sasiwan; Eaimworawuthikul, Sathima; Thiennimitr, Parameth; Pongchaidecha, Anchalee; Lungkaphin, Anusorn; Pratchayasakul, Wasana; Chattipakorn, Siriporn C.; Chattipakorn, Nipon] Chiang Mai Univ, Cardiac Electrophysiol Res & Training Ctr, Fac Med, Chiang Mai 50200, Thailand.
   [Tunapong, Wannipa; Apaijai, Nattayaporn; Tanajak, Pongpan; Wanchai, Keerati; Chunchai, Titikorn; Kerdphoo, Sasiwan; Eaimworawuthikul, Sathima; Pongchaidecha, Anchalee; Lungkaphin, Anusorn; Pratchayasakul, Wasana; Chattipakorn, Siriporn C.; Chattipakorn, Nipon] Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai 50200, Thailand.
   [Tunapong, Wannipa; Tanajak, Pongpan; Wanchai, Keerati; Chunchai, Titikorn; Pongchaidecha, Anchalee; Lungkaphin, Anusorn; Pratchayasakul, Wasana; Chattipakorn, Nipon] Chiang Mai Univ, Dept Physiol, Cardiac Electrophysiol Unit, Fac Med, Chiang Mai 50200, Thailand.
   [Yasom, Sakawdaurn; Thiennimitr, Parameth] Chiang Mai Univ, Dept Microbiol, Fac Med, Chiang Mai 50200, Thailand.
   [Chattipakorn, Siriporn C.] Chiang Mai Univ, Dept Oral Biol & Diagnost Sci, Fac Dent, Chiang Mai 50200, Thailand.
C3 Chiang Mai University; Chiang Mai University; Chiang Mai University;
   Chiang Mai University; Chiang Mai University
RP Chattipakorn, N (corresponding author), Chiang Mai Univ, Cardiac Electrophysiol Res & Training Ctr, Fac Med, Chiang Mai 50200, Thailand.; Chattipakorn, N (corresponding author), Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai 50200, Thailand.; Chattipakorn, N (corresponding author), Chiang Mai Univ, Dept Physiol, Cardiac Electrophysiol Unit, Fac Med, Chiang Mai 50200, Thailand.
EM nchattip@gmail.com
RI Tanajak, Pongpan/ABB-2347-2020; Chattipakorn, Nipon/AAJ-4049-2021;
   Thiennimitr, Parameth/AAH-1761-2019
OI Chattipakorn, Nipon/0000-0003-3026-718X; Chattipakorn,
   Siriporn/0000-0003-1677-7052; YASOM, SAKAWDAURN/0000-0002-6145-938X;
   pratchayasakul, wasana/0000-0003-3970-4323; Wanchai,
   Keerati/0000-0003-2282-7909; Chunchai, Titikorn/0000-0003-4405-1208;
   Thiennimitr, Parameth/0000-0002-6339-8744
FU Thailand Research Fund Grants RTA [TRG6080005, RSA5780029]; NSTDA
   Research Chair Grant from the National Science and Technology
   Development Agency Thailand; Chiang Mai University Center of Excellence
   Award
FX This work was supported by Thailand Research Fund Grants RTA (SCC),
   TRG6080005 (NA), RSA5780029 (AL); a NSTDA Research Chair Grant from the
   National Science and Technology Development Agency Thailand (NC), and
   Chiang Mai University Center of Excellence Award (NC). The authors would
   also like to thank Ms. Gabrielle Metzler for her editorial assistance.
CR Abildgaard A, 2017, BRAIN BEHAV IMMUN, DOI [10.1016/41)10.2017.04.017, DOI 10.1016/41)10.2017.04.017]
   Apaijai N, 2016, J ENDOCRINOL, V229, P245, DOI 10.1530/JOE-16-0096
   Apaijai N, 2013, BRIT J PHARMACOL, V169, P1048, DOI 10.1111/bph.12176
   Barbour Jayne Alexandra, 2014, Int J Cell Biol, V2014, P156020, DOI 10.1155/2014/156020
   Beserra BTS, 2015, CLIN NUTR, V34, P845, DOI 10.1016/j.clnu.2014.10.004
   Cabreiro F, 2013, EMBO MOL MED, V5, P1300, DOI 10.1002/emmm.201100972
   Campese VM, 2005, HYPERTENSION, V46, P533, DOI 10.1161/01.HYP.0000179088.57586.26
   Cani PD, 2008, DIABETES, V57, P1470, DOI 10.2337/db07-1403
   Cani PD, 2006, EUR J CLIN NUTR, V60, P567, DOI 10.1038/sj.ejcn.1602350
   Chattipakorn N, 2007, INT J CARDIOL, V120, P289, DOI 10.1016/j.ijcard.2006.11.221
   Chinda K, 2014, DIABETES VASC DIS RE, V11, P75, DOI 10.1177/1479164113516134
   Cluny NL, 2015, OBESITY, V23, P769, DOI 10.1002/oby.21017
   Delzenne NM, 2007, J NUTR, V137, p2547S, DOI 10.1093/jn/137.11.2547S
   Doucet É, 2008, METABOLISM, V57, P1458, DOI 10.1016/j.metabol.2008.05.017
   Everard A, 2013, P NATL ACAD SCI USA, V110, P9066, DOI 10.1073/pnas.1219451110
   Fallucca F, 2014, DIABETES-METAB RES, V30, P48, DOI 10.1002/dmrr.2518
   Feng MJ, 2008, AM J HYPERTENS, V21, P1288, DOI 10.1038/ajh.2008.301
   Forbes-Hernández TY, 2014, FOOD CHEM TOXICOL, V68, P154, DOI 10.1016/j.fct.2014.03.017
   Gao ZG, 2009, DIABETES, V58, P1509, DOI 10.2337/db08-1637
   Guerreiro I, 2015, AQUACULTURE, V441, P57, DOI 10.1016/j.aquaculture.2015.02.015
   Hamilton MK, 2015, AM J PHYSIOL-GASTR L, V308, pG840, DOI 10.1152/ajpgi.00029.2015
   Ilkun O, 2013, CURR PHARM DESIGN, V19, P4806, DOI 10.2174/1381612811319270003
   IMAIZUMI K, 1991, AGR BIOL CHEM TOKYO, V55, P199, DOI 10.1080/00021369.1991.10870553
   Jackson K. G., 2012, NUTR AGING, V1, P181, DOI DOI 10.3233/NUA-130017
   Kerkelä R, 2006, NAT MED, V12, P908, DOI 10.1038/nm1446
   Kumfu S, 2012, EUR J HAEMATOL, V88, P535, DOI 10.1111/j.1600-0609.2012.01779.x
   Lai CH, 2016, INT J MED SCI, V13, P277, DOI 10.7150/ijms.14769
   Li C, 2014, J FUNCT FOODS, V8, P340, DOI 10.1016/j.jff.2014.03.031
   Lim E, 2016, NUTRIENTS, V8, DOI 10.3390/nu8120791
   Lim SM, 2016, NUTR RES, V36, P337, DOI 10.1016/j.nutres.2015.12.001
   Marchesi JR, 2016, GUT, V65, P330, DOI 10.1136/gutjnl-2015-309990
   Mei XR, 2016, J AGR FOOD CHEM, V64, P7502, DOI 10.1021/acs.jafc.6b03474
   Nickel A, 2014, J MOL CELL CARDIOL, V73, P26, DOI 10.1016/j.yjmcc.2014.03.011
   Palee S, 2013, EXP PHYSIOL, V98, P1028, DOI 10.1113/expphysiol.2012.070433
   Park DY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059470
   Parnell JA, 2009, AM J CLIN NUTR, V89, P1751, DOI 10.3945/ajcn.2009.27465
   Pongchaidecha A, 2009, NUTRITION, V25, P870, DOI 10.1016/j.nut.2009.02.001
   Pongkan W, 2016, J ENDOCRINOL, V229, P209, DOI 10.1530/JOE-16-0002
   Rajpal DK, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0145499
   Samniang B, 2016, SCI REP-UK, V6, DOI 10.1038/srep19749
   Schulz MD, 2014, NATURE, V514, P508, DOI 10.1038/nature13398
   Sivasinprasasn S, 2016, MENOPAUSE, V23, P894, DOI 10.1097/GME.0000000000000640
   Slavin J, 2013, NUTRIENTS, V5, P1417, DOI 10.3390/nu5041417
   Song M, 2015, J DAIRY SCI, V98, P1492, DOI 10.3168/jds.2014-8586
   Stenman LK, 2014, BENEF MICROBES, V5, P437, DOI 10.3920/BM2014.0014
   Supakul L, 2014, EUR J NUTR, V53, P919, DOI 10.1007/s00394-013-0595-6
   Tanajak P, 2016, ACTA PHYSIOL, V217, P287, DOI 10.1111/apha.12698
   Ting WJ, 2015, BRIT J NUTR, V114, P706, DOI 10.1017/S0007114515002469
   Turnbaugh PJ, 2008, CELL HOST MICROBE, V3, P213, DOI 10.1016/j.chom.2008.02.015
   van den Heuvel JK, 2016, BRIT J PHARMACOL, V173, P1793, DOI 10.1111/bph.13477
   Wang HF, 2015, INT J MOL MED, V35, P460, DOI 10.3892/ijmm.2014.2021
   Wang JJ, 2015, ISME J, V9, P1, DOI 10.1038/ismej.2014.99
   Wu CC, 2015, EVID-BASED COMPL ALT, V2015, DOI 10.1155/2015/391767
   Yamamoto S, 2016, J PURE APPL MICROBIO, V10, P1727
   Ye SH, 2006, HYPERTENSION, V48, P309, DOI 10.1161/01.HYP.0000231307.69761.2e
   Zhu J, 2017, INT IMMUNOPHARMACOL, V43, P236, DOI 10.1016/j.intimp.2016.12.020
NR 56
TC 70
Z9 73
U1 4
U2 29
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD SEP
PY 2018
VL 57
IS 6
BP 2091
EP 2104
DI 10.1007/s00394-017-1482-3
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GQ7KL
UT WOS:000441919500006
PM 28608320
DA 2025-06-11
ER

PT J
AU Qin, FZ
   Siwik, DA
   Luptak, I
   Hou, XY
   Wang, L
   Higuchi, A
   Weisbrod, RM
   Ouchi, N
   Tu, VH
   Calamaras, TD
   Miller, EJ
   Verbeuren, TJ
   Walsh, K
   Cohen, RA
   Colucci, WS
AF Qin, Fuzhong
   Siwik, Deborah A.
   Luptak, Ivan
   Hou, Xiuyun
   Wang, Lei
   Higuchi, Akiko
   Weisbrod, Robert M.
   Ouchi, Noriyuki
   Tu, Vivian H.
   Calamaras, Timothy D.
   Miller, Edward J.
   Verbeuren, Tony J.
   Walsh, Kenneth
   Cohen, Richard A.
   Colucci, Wilson S.
TI The Polyphenols Resveratrol and S17834 Prevent the Structural and
   Functional Sequelae of Diet-Induced Metabolic Heart Disease in Mice
SO CIRCULATION
LA English
DT Article
DE diastolic dysfunction; left ventricular hypertrophy; metabolic syndrome;
   4-OH-2-nonenol; oxidative stress
ID ACTIVATED PROTEIN-KINASE; VENTRICULAR DIASTOLIC FUNCTION;
   MYOCARDIAL-INFARCTION; OXIDATIVE STRESS; DIABETIC CARDIOMYOPATHY;
   SCIENTIFIC STATEMENT; CARDIAC-HYPERTROPHY; A/J MICE; DYSFUNCTION;
   IMPROVES
AB Background-Diet-induced obesity is associated with metabolic heart disease characterized by left ventricular hypertrophy and diastolic dysfunction. Polyphenols such as resveratrol and the synthetic flavonoid derivative S17834 exert beneficial systemic and cardiovascular effects in a variety of settings including diabetes mellitus and chronic hemodynamic overload.
   Methods and Results-We characterized the structural and functional features of a mouse model of diet-induced metabolic syndrome and used the model to test the hypothesis that the polyphenols prevent myocardial hypertrophy and diastolic dysfunction. Male C57BL/6J mice were fed a normal diet or a diet high in fat and sugar (HFHS) with or without concomitant treatment with S17834 or resveratrol for up to 8 months. HFHS diet-fed mice developed progressive left ventricular hypertrophy and diastolic dysfunction with preservation of systolic function in association with myocyte hypertrophy and interstitial fibrosis. In HFHS diet-fed mice, there was increased myocardial oxidative stress with evidence of oxidant-mediated protein modification via tyrosine nitration and 4-OH-2-nonenol adduction. HFHS diet-fed mice also exhibited increases in plasma fasting glucose, insulin, and homeostasis model assessment of insulin resistance indicative of insulin resistance. Treatment with S17834 or resveratrol prevented left ventricular hypertrophy and diastolic dysfunction. For S17834, these beneficial effects were associated with decreases in oxidant-mediated protein modifications and hyperinsulinemia and increased plasma adiponectin.
   Conclusions-Resveratrol and S17834 administered concurrently with a HFHS diet prevent the development of left ventricular hypertrophy, interstitial fibrosis, and diastolic dysfunction. Multiple mechanisms may contribute to the beneficial effects of the polyphenols, including a reduction in myocardial oxidative stress and related protein modifications, amelioration of insulin resistance, and increased plasma adiponectin. The polyphenols resveratrol and S17834 may be of value in the prevention of diet-induced metabolic heart disease. (Circulation. 2012;125:1757-1764.)
C1 [Colucci, Wilson S.] Boston Univ, Med Ctr, Cardiovasc Med Sect, Dept Med, Boston, MA 02118 USA.
   Boston Univ, Med Ctr, Myocardial Unit, Boston, MA 02118 USA.
   Boston Univ, Med Ctr, Vasc Biol Unit, Boston, MA 02118 USA.
C3 Boston University; Boston University; Boston University
RP Colucci, WS (corresponding author), Boston Univ, Med Ctr, Cardiovasc Med Sect, Dept Med, 88 E Newton St, Boston, MA 02118 USA.
EM wilson.colucci@bmc.org
RI OUCHI, Noriyuki/I-7306-2014; zhou, zhou/HPE-9525-2023
OI Qin, Fuzhong/0000-0002-9534-3617; Luptak, Ivan/0000-0001-7498-7694;
   Colucci, Wilson/0000-0002-0576-9420; /0000-0002-1070-6408; Miller,
   Edward/0000-0002-2156-5962; /0000-0002-7166-327X
FU National Institutes of Health [HL-061639, HL-064750, HL031607, PO1 HL
   068758]; National Heart, Lung, and Blood Institute [N01-HV-28178];
   Strategic Alliance between Servier and the Vascular Biology Section,
   Boston University Medical Center
FX This study was supported by National Institutes of Health grants
   HL-061639 (Dr Colucci), HL-064750 (Dr Colucci), HL031607 (Dr Cohen), and
   PO1 HL 068758 (Drs Cohen and Walsh), the National Heart, Lung, and Blood
   Institute-sponsored Boston University Cardiovascular Proteomics Center
   (contract N01-HV-28178; Drs Cohen and Colucci), and a Strategic Alliance
   between Servier and the Vascular Biology Section, Boston University
   Medical Center (Dr Cohen).
CR Amin RH, 2010, AM J PHYSIOL-HEART C, V299, pH690, DOI 10.1152/ajpheart.01032.2009
   Bertrand L, 2008, CARDIOVASC RES, V79, P238, DOI 10.1093/cvr/cvn093
   Bonnard C, 2008, J CLIN INVEST, V118, P789, DOI 10.1172/JCI32601
   Borlaug BA, 2006, TRENDS CARDIOVAS MED, V16, P273, DOI 10.1016/j.tcm.2006.05.003
   Burstein B, 2007, J PHARMACOL EXP THER, V323, P916, DOI 10.1124/jpet.107.127548
   Cayatte AJ, 2001, ARTERIOSCL THROM VAS, V21, P1577, DOI 10.1161/hq1001.096723
   Chen YR, 2008, CARDIOVASC DRUG THER, V22, P479, DOI 10.1007/s10557-008-6141-8
   Chiu HC, 2005, CIRC RES, V96, P225, DOI 10.1161/01.RES.0000154079.20681.B9
   Dolinsky VW, 2009, CIRCULATION, V119, P1643, DOI 10.1161/CIRCULATIONAHA.108.787440
   Eberli FR, 1998, J MOL CELL CARDIOL, V30, P1443, DOI 10.1006/jmcc.1998.0702
   Gallou-Kabani C, 2007, OBESITY, V15, P1996, DOI 10.1038/oby.2007.238
   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hartil K, 2005, J MOL CELL CARDIOL, V39, P581, DOI 10.1016/j.yjmcc.2005.07.005
   Hou XY, 2008, J BIOL CHEM, V283, P20015, DOI 10.1074/jbc.M802187200
   Juric D, 2007, AM J PHYSIOL-HEART C, V292, pH2138, DOI 10.1152/ajpheart.00852.2006
   Kenchaiah S, 2002, NEW ENGL J MED, V347, P305, DOI 10.1056/NEJMoa020245
   Kuster GM, 2005, CIRCULATION, V111, P1192, DOI 10.1161/01.CIR.0000157148.59308.F5
   Lagouge M, 2006, CELL, V127, P1109, DOI 10.1016/j.cell.2006.11.013
   Lin JF, 2008, LIFE SCI, V83, P313, DOI 10.1016/j.lfs.2008.06.016
   Milne JC, 2007, NATURE, V450, P712, DOI 10.1038/nature06261
   Mottillo S, 2010, J AM COLL CARDIOL, V56, P1113, DOI 10.1016/j.jacc.2010.05.034
   Nagueh SF, 2009, EUR J ECHOCARDIOGR, V10, P165, DOI [10.1093/ejechocard/jep007, 10.1016/j.echo.2008.11.023]
   Parekh PI, 1998, METABOLISM, V47, P1089, DOI 10.1016/S0026-0495(98)90283-9
   Poirier P, 2006, CIRCULATION, V113, P898, DOI 10.1161/CIRCULATIONAHA.106.171016
   Poornima IG, 2006, CIRC RES, V98, P596, DOI 10.1161/01.RES.0000207406.94146.c2
   Qin FZ, 2010, CIRC-HEART FAIL, V3, P306, DOI 10.1161/CIRCHEARTFAILURE.109.864785
   REBUFFESCRIVE M, 1993, METABOLISM, V42, P1405, DOI 10.1016/0026-0495(93)90190-Y
   Russell RR, 2004, J CLIN INVEST, V114, P495, DOI 10.1172/JCI200419297
   Sawyer DB, 2002, J MOL CELL CARDIOL, V34, P379, DOI 10.1006/jmcc.2002.1526
   Schaefer A, 2003, J AM SOC ECHOCARDIOG, V16, P1144, DOI 10.1067/S0894-7317(03)00679-5
   Shibata R, 2004, NAT MED, V10, P1384, DOI 10.1038/nm1137
   Sulaiman M, 2010, AM J PHYSIOL-HEART C, V298, pH833, DOI 10.1152/ajpheart.00418.2009
   SURWIT RS, 1995, METABOLISM, V44, P645, DOI 10.1016/0026-0495(95)90123-X
   Thandapilly SJ, 2010, AM J HYPERTENS, V23, P192, DOI 10.1038/ajh.2009.228
   Tsujita Y, 2005, ECHOCARDIOGR-J CARD, V22, P245, DOI 10.1111/j.0742-2822.2005.04014.x
   von Bibra H, 2010, DIABETOLOGIA, V53, P1033, DOI 10.1007/s00125-010-1682-3
   Wang AP, 2011, J BIOL CHEM, V286, P60, DOI 10.1074/jbc.M110.188144
   Wojciechowski P, 2010, J NUTR, V140, P962, DOI 10.3945/jn.109.115006
   Zang MW, 2006, DIABETES, V55, P2180, DOI 10.2337/db05-1188
   Zhang HR, 2010, AM J PHYSIOL-HEART C, V299, pH985, DOI 10.1152/ajpheart.00489.2010
NR 40
TC 98
Z9 113
U1 1
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD APR 10
PY 2012
VL 125
IS 14
BP 1757
EP U127
DI 10.1161/CIRCULATIONAHA.111.067801
PG 14
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 925WR
UT WOS:000302793300017
PM 22388319
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Mizuno, K
   Watanabe, K
   Yamano, E
   Ebisu, K
   Tajima, K
   Nojima, J
   Ohsaki, Y
   Kabayama, S
   Watanabe, Y
AF Mizuno, Kei
   Watanabe, Kyosuke
   Yamano, Emi
   Ebisu, Kyoko
   Tajima, Kanako
   Nojima, Junzo
   Ohsaki, Yusuke
   Kabayama, Shigeru
   Watanabe, Yasuyoshi
TI Antioxidant effects of continuous intake of electrolyzed hydrogen water
   in healthy adults
SO HELIYON
LA English
DT Article
DE Electrolyzed hydrogen water; Antioxidant oxidative stress; In
   flammation; LDL cholesterol; Renal function
ID SUBCUTANEOUS ADIPOSE-TISSUE; OXIDATIVE STRESS; METABOLIC SYNDROME;
   REDUCED WATER; ASSOCIATION; FATIGUE; MARKER
AB Chronic oxidative stress induces deterioration of health and a risk for the onset of various diseases. Previous clinical studies revealed that electrolyzed hydrogen water (EHW) is effective to reduce oxidative stress during hemodialysis in patients with chronic dialysis. In the present observational study, we investigated the antioxidant effects of a daily continuous intake of EHW in healthy adults. The concentrations of serum reactive oxygen metabolites-derived compounds (d-ROMs) and blood urea nitrogen in healthy volunteers (n = 64) who had a habit of intake over 500 mL/day of EHW at least 5 days a week for longer than 6 months were lower than those of age-and sex-matched controls (n = 470) without the habit of EHW intake. Oxidation stress index which the ratio between concentrations in d-ROMs and biological antioxidant potential was correlated with the serum concentration of high-sensitivity C-reactive protein or low-density lipoprotein cholesterol in the EHW group. These re-sults suggest that the continuous intake of EHW induces antioxidant effects and may contribute to alleviate the risk of various oxidative stress-related dysfunctions and diseases in healthy adults.
C1 [Mizuno, Kei; Watanabe, Kyosuke; Yamano, Emi; Ebisu, Kyoko; Tajima, Kanako; Watanabe, Yasuyoshi] RIKEN Ctr Biosyst Dynam Res, Lab Pathophysiol & Hlth Sci, Chuo Ku, 6-7-3 Minatojima Minamimachi, Kobe, Hyogo 6500047, Japan.
   [Mizuno, Kei; Watanabe, Kyosuke; Yamano, Emi; Ebisu, Kyoko; Tajima, Kanako; Watanabe, Yasuyoshi] RIKEN Compass Healthy Life Res Complex Program, Chuo Ku, 6-7-1 Minatojima Minamimachi, Kobe, Hyogo 6500047, Japan.
   [Mizuno, Kei; Watanabe, Kyosuke; Yamano, Emi; Watanabe, Yasuyoshi] Osaka City Univ, Kita Ku, Ctr Hlth Sci Innovat, 3-1 Ofuka Cho, Osaka, Osaka 5300011, Japan.
   [Nojima, Junzo] Yamaguchi Univ, Dept Lab Sci, Fac Hlth Sci, Grad Sch Med, I-1-1 Minami Kogushi, Ube, Yamaguchi 7558505, Japan.
   [Ohsaki, Yusuke] Tohoku Univ, Grad Sch Agr Sci, Lab Nutr, Aoba Ku, 468-1 Aramaki Aza Aoba, Sendai, Miyagi 9808572, Japan.
   [Kabayama, Shigeru] Trim Med Inst Co Ltd, 22F HERBIS ENT Off Tower 2-2-22 Umeda,City, Osaka, Osaka 5300001, Japan.
C3 RIKEN; Osaka Metropolitan University; Yamaguchi University; Tohoku
   University
RP Watanabe, Y (corresponding author), RIKEN Ctr Biosyst Dynam Res, Lab Pathophysiol & Hlth Sci, Chuo Ku, 6-7-3 Minatojima Minamimachi, Kobe, Hyogo 6500047, Japan.; Watanabe, Y (corresponding author), RIKEN Compass Healthy Life Res Complex Program, Chuo Ku, 6-7-1 Minatojima Minamimachi, Kobe, Hyogo 6500047, Japan.; Watanabe, Y (corresponding author), Osaka City Univ, Kita Ku, Ctr Hlth Sci Innovat, 3-1 Ofuka Cho, Osaka, Osaka 5300011, Japan.
EM yywata@riken.jp
RI Yamano, Emi/AAL-6201-2020; kabayama, shigeru/MFH-2923-2025
OI Watanabe, Yasuyoshi/0000-0003-2623-5599; Watanabe,
   Kyosuke/0000-0001-6261-5690
FU Nihon Trim Co., Ltd [2022-0250]; Japan Science and Technology Agency
   (JST) [RC-01]; Grants-in-Aid for Scientific Research [20K05918] Funding
   Source: KAKEN
FX This work was supported by Nihon Trim Co., Ltd (2022-0250) and RIKEN
   Compass to Healthy Life Research Complex Program (RC-01) of the Japan
   Science and Technology Agency (JST).
CR [Anonymous], 2018, CLIN INTERV AGING, DOI DOI 10.2147/CIA.S158513
   Arsenault BJ, 2009, AM J CARDIOL, V104, P240, DOI 10.1016/j.amjcard.2009.03.027
   Fox CS, 2007, CIRCULATION, V116, P39, DOI 10.1161/CIRCULATIONAHA.106.675355
   Fukuda S, 2016, BIOL PSYCHOL, V118, P88, DOI 10.1016/j.biopsycho.2016.05.005
   Fukui T, 2011, HYPERTENS RES, V34, P1041, DOI 10.1038/hr.2011.76
   Hamasaki T, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0171192
   Herrington W, 2016, CIRC RES, V118, P535, DOI 10.1161/CIRCRESAHA.115.307611
   Hotamisligil GS, 2010, CELL, V140, P900, DOI 10.1016/j.cell.2010.02.034
   Hu D, 2021, BIOCHEM BIOPH RES CO, V535, P1, DOI 10.1016/j.bbrc.2020.12.035
   Huang KC, 2006, KIDNEY INT, V70, P391, DOI 10.1038/sj.ki.5001576
   Huang KC, 2003, KIDNEY INT, V64, P704, DOI 10.1046/j.1523-1755.2003.00118.x
   Kim MJ, 2006, LIFE SCI, V79, P2288, DOI 10.1016/j.lfs.2006.07.027
   Kotani K, 2012, J INT MED RES, V40, P1074, DOI 10.1177/147323001204000326
   Masudo R, 2017, J CLIN BIOCHEM NUTR, V61, P79, DOI 10.3164/jcbn.17-5
   Nakao YM, 2012, P JPN ACAD B-PHYS, V88, P454, DOI 10.2183/pjab.88.454
   Nojima J, 2011, BRIT J HAEMATOL, V155, P528, DOI 10.1111/j.1365-2141.2011.08719.x
   Ogawa S, 2022, DIABETOL INT, V13, P209, DOI 10.1007/s13340-021-00524-3
   Ogura Y, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10081198
   Tanaka M, 2015, J PHYSIOL SCI, V65, P483, DOI 10.1007/s12576-015-0399-y
   Tsujimoto Y, 2021, RENAL REPLACE THER, V7, DOI 10.1186/s41100-021-00376-2
   Tu AW, 2017, DIAB MET SYND CLIN R, V11, pS957, DOI 10.1016/j.dsx.2017.07.022
   Yano S, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10050801
NR 22
TC 2
Z9 2
U1 2
U2 9
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD NOV
PY 2022
VL 8
IS 11
AR e11853
DI 10.1016/j.heliyon.2022.e11853
EA NOV 2022
PG 4
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 8L1EK
UT WOS:000923531700013
PM 36468139
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Adams, SW
   Allwood, MA
AF Adams, Shane W.
   Allwood, Maureen A.
TI Parallel Processes of Posttraumatic Stress and Cardiometabolic
   Dysfunction: A Systemic Illness of Traumatic Stress
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE posttraumatic stress disorder; traumatic stress; physical health;
   cardiometabolic; systemic illness
ID WORLD-TRADE-CENTER; METABOLIC SYNDROME; HEART-DISEASE; SEPTEMBER 11;
   DISORDER; VALIDITY; RISK; CONSEQUENCES; LONELINESS; PREVALENCE
AB Objective: To determine if and how cardiometabolic conditions (MetC) may be associated with posttraumatic stress disorder (PTSD) symptoms over time when controlling for the influence of potentially confounding variables. Method: Parallel process latent growth modeling was applied to self-reported longitudinal data collected from 35,788 World Trade Center 9/11 survivors to determine how the development and course of PTSD symptoms and MetC influence each other when controlling for age, sex, race/ethnicity, preexisting traumas, physical health problems, general psychological distress, smoking, and alcohol use. Results: A unidirectional relationship was found in which the intercept of PTSD symptoms predicted the slope of MetC. Hyperarousal (beta = .172) and emotional numbing (beta = .171) PTSD symptoms demonstrated the strongest association with MetC changes over and above the effects of control variables and potential confounders. Post hoc analyses indicated that utilization of PTSD-related psychotherapy was associated with decreased early presentations of MetC following trauma, which may have vital implications for the integrated treatment of trauma-exposed individuals. Conclusions: Findings have strong theoretical and clinical implications for conceptualizing traumatic stress reactions as systemic processes and utilizing integrated treatment practices following psychological trauma.
C1 [Adams, Shane W.; Allwood, Maureen A.] CUNY, John Jay Coll Criminal Justice, Dept Psychol, New York, NY USA.
   [Adams, Shane W.; Allwood, Maureen A.] CUNY, Grad Ctr, Dept Psychol, New York, NY USA.
   [Adams, Shane W.] VA Palo Alto Hlth Care Syst, 3801 Miranda Ave, Palo Alto, CA 94304 USA.
C3 City University of New York (CUNY) System; City University of New York
   (CUNY) System; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Palo Alto Health Care System
RP Adams, SW (corresponding author), VA Palo Alto Hlth Care Syst, 3801 Miranda Ave, Palo Alto, CA 94304 USA.
EM swadams2@gmail.com
RI Adams, Shane/V-1657-2019
CR Adams SW, 2019, J TRAUMA STRESS, V32, P67, DOI 10.1002/jts.22357
   Barr ELM, 2009, INTERN MED J, V39, P49, DOI 10.1111/j.1445-5994.2008.01864.x
   Bartoli F, 2013, METAB SYNDR RELAT D, V11, P301, DOI 10.1089/met.2013.0010
   Berenbaum H, 2013, J ABNORM PSYCHOL, V122, P894, DOI 10.1037/a0033096
   Bourassa KJ, 2021, J TRAUMA STRESS, V34, P384, DOI 10.1002/jts.22637
   Brackbill RM, 2014, AM J EPIDEMIOL, V179, P1076, DOI 10.1093/aje/kwu022
   Bryant RA, 2017, JAMA PSYCHIAT, V74, P135, DOI 10.1001/jamapsychiatry.2016.3470
   Cacioppo JT, 2015, ANNU REV PSYCHOL, V66, P733, DOI 10.1146/annurev-psych-010814-015240
   Carlson NR., 2017, Physiology of behavior, V12th, P554
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Cumming G, 2009, STAT MED, V28, P205, DOI 10.1002/sim.3471
   Edmondson D, 2017, LANCET PSYCHIAT, V4, P320, DOI 10.1016/S2215-0366(16)30377-7
   Farfel M, 2008, J URBAN HEALTH, V85, P880, DOI 10.1007/s11524-008-9317-4
   Frueh BC, 2020, INT J PSYCHIAT MED, V55, P281, DOI 10.1177/0091217420906659
   Galatzer-Levy IR, 2014, J CLIN PSYCHIAT, V75, pE950, DOI 10.4088/JCP.14com09372
   Gargano LM, 2018, INT J ENV RES PUB HE, V15, DOI 10.3390/ijerph15020253
   Geldhof GJ, 2013, EDUC PSYCHOL MEAS, V73, P27, DOI 10.1177/0013164412445473
   Grundy S., 2005, CRITICAL PATHWAYS CA, V4, p198 203
   Hansen H, 2014, BMC FAM PRACT, V15, DOI 10.1186/1471-2296-15-39
   Hawkley Louise C, 2010, Ann Behav Med, V40, P218, DOI 10.1007/s12160-010-9210-8
   Jackson JM, 2013, J CLIN EPIDEMIOL, V66, P349, DOI 10.1016/j.jclinepi.2012.01.013
   Jordan HT, 2011, PREV MED, V53, P370, DOI 10.1016/j.ypmed.2011.10.014
   Joshi R, 2009, INTERN MED J, V39, P5, DOI 10.1111/j.1445-5994.2008.01859.x
   Jung T, 2008, SOC PERSONAL PSYCHOL, V2, P302, DOI 10.1111/j.1751-9004.2007.00054.x
   Kessler RC, 2002, PSYCHOL MED, V32, P959, DOI 10.1017/S0033291702006074
   Koenen KC, 2017, PSYCHOL MED, V47, P209, DOI [10.1017/s0033291716002294, 10.1017/S0033291716002294]
   Lohr JB, 2015, AM J GERIAT PSYCHIAT, V23, P709, DOI 10.1016/j.jagp.2015.04.001
   McEwen Bruce S, 2006, Dialogues Clin Neurosci, V8, P367
   McFarlane AC, 2010, WORLD PSYCHIATRY, V9, P3
   Meinhausen C, 2022, HEALTH PSYCHOL, V41, P663, DOI 10.1037/hea0001143
   Michopoulos V, 2016, EXP NEUROL, V284, P220, DOI 10.1016/j.expneurol.2016.05.038
   Miller-Archie SA, 2014, PREV MED, V66, P34, DOI 10.1016/j.ypmed.2014.05.016
   Moline JM, 2016, AM J IND MED, V59, P752, DOI 10.1002/ajim.22649
   Moreira FP, 2019, PSYCHIAT RES, V271, P306, DOI 10.1016/j.psychres.2018.08.009
   Muthn B., 2004, Handbook of quantitative methodology for the social sciences, P345, DOI 10.4135/9781412986311.n19
   Nelson DE, 2001, SOZ PRAVENTIV MED, V46, pS3
   Norman GJ., 2012, How motivation affects cardiovascular response: Mechanisms and applications, P307, DOI [10.1037/13090-015, DOI 10.1037/13090-015]
   Pietrzak RH, 2014, J AFFECT DISORDERS, V162, P102, DOI 10.1016/j.jad.2014.03.024
   Pietrzak RH, 2010, PSYCHIAT RES, V178, P323, DOI 10.1016/j.psychres.2010.04.039
   Rosenbaum S, 2015, METABOLISM, V64, P926, DOI [10.1016/j.metabol.2015.04.009, 10.1016/j.metabol.2015.01.016]
   Scherrer JF, 2019, J AM HEART ASSOC, V8, DOI 10.1161/JAHA.118.011133
   Schnurr P.P., 2017, APA Handbook of trauma psychology: Foundations in knowledge, P349, DOI [DOI 10.1037/0000019-018, 10.1037/0000019-018]
   Skinner KM, 2005, J AMBUL CARE MANAG, V28, P102, DOI 10.1097/00004479-200504000-00002
   Smith EC, 2019, PREHOSP DISASTER MED, V34, P625, DOI 10.1017/S1049023X19004989
   Solomon Z, 2009, J CLIN PSYCHIAT, V70, P837, DOI 10.4088/JCP.08m04347
   Valtorta NK, 2016, HEART, V102, P1009, DOI 10.1136/heartjnl-2015-308790
   Weathers F.W., 1994, PTSD Checklist: Civilian version
   Wilkins KC, 2011, DEPRESS ANXIETY, V28, P596, DOI 10.1002/da.20837
   Wolf EJ, 2016, PSYCHOL MED, V46, P2215, DOI 10.1017/S0033291716000817
   Yehuda R, 2015, NAT REV DIS PRIMERS, V1, DOI 10.1038/nrdp.2015.57
   Zoladz PR, 2013, NEUROSCI BIOBEHAV R, V37, P860, DOI 10.1016/j.neubiorev.2013.03.024
NR 51
TC 4
Z9 4
U1 0
U2 7
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD MAY
PY 2024
VL 43
IS 5
BP 365
EP 375
DI 10.1037/hea0001347
EA DEC 2023
PG 11
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA I1J5K
UT WOS:001128695500001
PM 38127510
DA 2025-06-11
ER

PT J
AU Musazadeh, V
   Mahmoudinezhad, M
   Hamidi, N
   Falahatzadeh, M
   Shidfar, F
AF Musazadeh, Vali
   Mahmoudinezhad, Mahsa
   Hamidi, Niloofar
   Falahatzadeh, Maryam
   Shidfar, Farzad
TI Effects of walnut consumption on biomarkers of oxidative stress: A
   systematic review and meta-analysis of randomized controlled trials
SO PROSTAGLANDINS & OTHER LIPID MEDIATORS
LA English
DT Review
DE Biomarker; Meta-analysis; Metabolic syndrome; Stress oxidative; Walnut
ID ANTIOXIDANT STATUS; CAPACITY; POLYPHENOLS; DERIVATIVES; PLASMA; PHASE;
   ASSAY; ACID; MEAT
AB Oxidative stress is caused by an imbalance between accumulation and production of oxygen reactive species (ROS) in tissues and cells and play a key role in many diseases. This systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to analyze the effects of walnut consumption on biomarkers of oxidative stress. Databases including PubMed, Scopus, Embase and Web of science were searched until November 30th, 2024. Data were subjected to meta-analysis using a random effects model to examine the effect sizes of the pooled results. Four studies were identified eligible to be included in current meta-analysis. Walnut consumption resulted in a significant increase in catalase activity (CAT) (WMD: 42.20; 95 % CI: 34.28, 50.11). Walnut consumption did not affect other biomarkers of oxidative stress such as lipid peroxidation (LPO), reduced glutathione (GSH), oxidized glutathione (GSSG) and oxygen radical absorbance capacity (ORAC). Overall, this meta-analysis demonstrated walnut consumption increase CAT, but did not affect other biomarkers of oxidative stress. This suggests that walnut may have played an indirect and mild role in health. However, due to the limited number of studies, further investigations is suggested in this regard.
C1 [Musazadeh, Vali; Hamidi, Niloofar] Iran Univ Med Sci, Student Res Comm, Sch Publ Hlth, Tehran, Iran.
   [Musazadeh, Vali; Shidfar, Farzad] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran.
   [Mahmoudinezhad, Mahsa] Urmia Univ Med Sci, Student Res Comm, Orumiyeh, Iran.
   [Mahmoudinezhad, Mahsa] Urmia Univ Med Sci, Food & Beverages Safety Res Ctr, Orumiyeh, Iran.
   [Falahatzadeh, Maryam] Shiraz Univ Med Sci, Dept Pharm, Shiraz, Iran.
C3 Iran University of Medical Sciences; Iran University of Medical
   Sciences; Urmia University of Medical Sciences; Urmia University of
   Medical Sciences; Shiraz University of Medical Science
RP Shidfar, F (corresponding author), Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran.
EM Mosazadeh.vali05@gmail.com; farzadshidfar@yahoo.com
RI Shidfar, Farzad/H-6651-2018
FU Student Research Committee, School of Public Health, Iran University of
   Medical Sciences, Tehran, Iran Tehran, Iran [33392]
FX This study was financially supported by a grant from the Student
   Research Committee, School of Public Health, Iran University of Medical
   Sciences, Tehran, Iran Tehran, Iran (Registration code: 33392) .
CR Alexandrova ML, 2005, FREE RADICAL BIO MED, V39, P297, DOI 10.1016/j.freeradbiomed.2005.04.017
   Anderson KJ, 2001, J NUTR, V131, P2837, DOI 10.1093/jn/131.11.2837
   Berryman CE, 2013, J NUTR, V143, P788, DOI 10.3945/jn.112.170993
   Çakmakçi S, 2015, INT J FOOD SCI TECH, V50, P472, DOI 10.1111/ijfs.12637
   Canales A, 2007, J AM COLL NUTR, V26, P225, DOI 10.1080/07315724.2007.10719605
   CAO GH, 1993, FREE RADICAL BIO MED, V14, P303, DOI 10.1016/0891-5849(93)90027-R
   Cherubini A, 2005, FREE RADICAL BIO MED, V39, P841, DOI 10.1016/j.freeradbiomed.2005.06.025
   Davis L, 2007, EUR J NUTR, V46, P155, DOI 10.1007/s00394-007-0647-x
   Feldman EB, 2002, J NUTR, V132, p1062S, DOI 10.1093/jn/132.5.1062S
   Fukuda T, 2004, BIOFACTORS, V21, P251, DOI 10.1002/biof.552210148
   Fukuda T, 2003, PHYTOCHEMISTRY, V63, P795, DOI 10.1016/S0031-9422(03)00333-9
   GLAZER AN, 1990, METHOD ENZYMOL, V186, P161
   Göçer H, 2013, ARCH PHARM, V346, P783, DOI 10.1002/ardp.201300228
   Haddad EH, 2014, NUTR J, V13, DOI 10.1186/1475-2891-13-4
   Halliwell B., 2015, Free Radicals in Biology and Medicine
   Higgins J, 2012, COCHRANE DB SYST REV, DOI 10.1002/14651858.ED000049
   Hozo SP., 2005, BMC MED RES METHODOL, V5, DOI [10.1186/1471-2288-5-13, DOI 10.1186/1471-2288-5-13]
   Hudthagosol C., 2012, Journal of the Medical Association of Thailand= Chotmaihet thangphaet, V95, pS179
   Ito H, 2007, J AGR FOOD CHEM, V55, P672, DOI 10.1021/jf062872b
   Sánchez-Muniz FJ, 2012, J AM COLL NUTR, V31, P194, DOI 10.1080/07315724.2012.10720027
   Jovanovic S.V., 1998, Antioxidant properties of flavonoids: reduction potentials and electron transfer reactions of flavonoid radicals
   Leopoldini M, 2004, J PHYS CHEM A, V108, P92, DOI 10.1021/jp035901j
   Leopoldini M, 2004, J PHYS CHEM A, V108, P4916, DOI 10.1021/jp037247d
   Leopoldini M, 2004, THEOR CHEM ACC, V111, P210, DOI 10.1007/s00214-003-0544-1
   Lepetsos P, 2016, BBA-MOL BASIS DIS, V1862, P576, DOI 10.1016/j.bbadis.2016.01.003
   Li L, 2006, J AGR FOOD CHEM, V54, P8033, DOI 10.1021/jf0612171
   Luo BF, 2023, COMPLEMENT THER MED, V73, DOI 10.1016/j.ctim.2023.102935
   MAAS JL, 1991, HORTSCIENCE, V26, P10, DOI 10.21273/HORTSCI.26.1.10
   Martínez ML, 2010, J SCI FOOD AGR, V90, P1959, DOI 10.1002/jsfa.4059
   Moher D, 2010, INT J SURG, V8, P336, DOI [10.1016/j.ijsu.2010.02.007, 10.1186/2046-4053-4-1, 10.1136/bmj.b2535, 10.1371/journal.pmed.1000097, 10.1136/bmj.b2700, 10.1016/j.ijsu.2010.07.299, 10.1136/bmj.i4086]
   Pizzino G, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/8416763
   Salas-Coronado R., 2019, Antioxidants, V10, P1, DOI DOI 10.5772/INTECHOPEN.85270
   Sharifi-Rad M, 2020, FRONT PHYSIOL, V11, DOI 10.3389/fphys.2020.00694
   Torabian S, 2009, J HUM NUTR DIET, V22, P64, DOI 10.1111/j.1365-277X.2008.00923.x
   Wright JS, 2001, J AM CHEM SOC, V123, P1173, DOI 10.1021/ja002455u
NR 35
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1098-8823
EI 2212-196X
J9 PROSTAG OTH LIPID M
JI Prostaglandins Other Lipid Mediat.
PD JUN
PY 2025
VL 178
AR 106986
DI 10.1016/j.prostaglandins.2025.106986
PG 6
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 1FU9M
UT WOS:001464009400001
PM 40187548
DA 2025-06-11
ER

PT J
AU Lotti, F
   Maggi, M
AF Lotti, Francesco
   Maggi, Mario
TI Sexual dysfunction and male infertility
SO NATURE REVIEWS UROLOGY
LA English
DT Review
ID PREMATURE EJACULATION SYNDROMES; 4TH INTERNATIONAL CONSULTATION; SEMEN
   QUALITY IMPAIRMENT; HELP-SEEKING BEHAVIOR; ERECTILE DYSFUNCTION;
   CLOMIPHENE CITRATE; HEALTH-STATUS; DOUBLE-BLIND; TESTOSTERONE LEVELS;
   METABOLIC SYNDROME
AB Infertility affects up to 12% of all men, and sexual dysfunction occurs frequently in men of reproductive age, causing infertility in some instances. In infertile men, hypoactive sexual desire and lack of sexual satisfaction are the most prevalent types of sexual dysfunction, ranging from 8.9% to 68.7%. Erectile dysfunction and/or premature ejaculation, evaluated with validated tools, have a prevalence of one in six infertile men, and orgasmic dysfunction has a prevalence of one in ten infertile men. In addition, infertile men can experience a heavy psychological burden. Infertility and its associated psychological concerns can underlie sexual dysfunction. Furthermore, general health perturbations can lead to male infertility and/or sexual dysfunction. Erectile dysfunction and male infertility are considered proxies for general health, the former underlying cardiovascular disorders and the latter cancerous and noncancerous conditions. The concept that erectile dysfunction in infertile men might be an early marker of poor general health is emerging. Finally, medications used for general health problems can cause sperm abnormalities and sexual dysfunction. The treatment of some causes of male infertility might improve semen quality and reverse infertility-related sexual dysfunction. In infertile men, an investigation of sexual, general, and psychological health status is advisable to improve reproductive problems and general health.
C1 [Lotti, Francesco; Maggi, Mario] Univ Florence, Dept Expt & Clin Biomed Sci, Sexual Med & Androl Unit, Florence, Italy.
C3 University of Florence
RP Maggi, M (corresponding author), Univ Florence, Dept Expt & Clin Biomed Sci, Sexual Med & Androl Unit, Florence, Italy.
EM m.maggi@dfc.unifi.it
RI Maggi, Mario/AAB-8284-2019; Lotti, Francesco/AAC-3186-2019; LOTTI,
   Francesco/K-1801-2018
OI MAGGI, Mario/0000-0003-3267-4221; LOTTI, Francesco/0000-0001-8343-1807
FU Ministry of University and Scientific Research (SIR project)
   [RBSI14LFMQ]
FX This work is funded by the Ministry of University and Scientific
   Research (SIR project to F.L. protocol number: RBSI14LFMQ).
CR Adelman WP, 2005, PEDIATR CLIN N AM, V52, P199, DOI 10.1016/j.pcl.2004.11.003
   Ahmed AF, 2015, ANDROLOGIA, V47, P276, DOI 10.1111/and.12256
   Akbal C, 2010, UROLOGY, V75, P598, DOI 10.1016/j.urology.2009.07.1330
   Althof SE, 2016, UROLOGY, V93, P9, DOI 10.1016/j.urology.2016.02.018
   Amory JK, 2007, J CLIN ENDOCR METAB, V92, P1659, DOI 10.1210/jc.2006-2203
   ANDREWS FM, 1991, J HEALTH SOC BEHAV, V32, P238, DOI 10.2307/2136806
   Annam K, 2016, J ONCOL PRACT, V12, P297, DOI 10.1200/JOP.2016.010678
   [Anonymous], 1981, LANCET, V2, P539
   [Anonymous], 2013, Endotext
   [Anonymous], COCHRANE DATABASE SY
   [Anonymous], 2010, WHO Laboratory Manual for the Examination and Processing of Human Semen
   [Anonymous], NEPHROUROL MON
   Atsuta N, 2006, BRAIN, V129, P1446, DOI 10.1093/brain/awl096
   Baker HWG, 1998, ENDOCRIN METAB CLIN, V27, P831
   Barazani Y, 2012, ASIAN J ANDROL, V14, P525, DOI 10.1038/aja.2012.29
   Bayar U, 2014, J PAK MED ASSOC, V64, P138
   Bechoua S, 2016, ANDROLOGY-US, V4, P395, DOI 10.1111/andr.12160
   Behre HM, 2010, ANDROLOGY: MALE REPRODUCTIVE HEALTH AND DYSFUNCTION, THIRD EDITION, P169, DOI 10.1007/978-3-540-78355-8_12
   BERGER DM, 1980, FERTIL STERIL, V34, P154
   BERGER DM, 1980, AM J PSYCHIAT, V137, P1047
   Berger Michael H, 2016, Sex Med Rev, V4, P353, DOI 10.1016/j.sxmr.2016.05.002
   Boddi V, 2014, J SEX MED, V11, P431, DOI 10.1111/jsm.12382
   Boivin J, 2007, HUM REPROD, V22, P1506, DOI 10.1093/humrep/dem046
   Bona G, 2002, HORM RES, V57, P63, DOI 10.1159/000058103
   Brandes M, 2010, HUM REPROD, V25, P118, DOI 10.1093/humrep/dep341
   Burra P, 2013, BEST PRACT RES CL GA, V27, P553, DOI 10.1016/j.bpg.2013.06.014
   BUVAT J, 1987, UROLOGY, V30, P216, DOI 10.1016/0090-4295(87)90237-8
   CAMINOSTORRES R, 1977, J CLIN ENDOCR METAB, V45, P255, DOI 10.1210/jcem-45-2-255
   Campbell JM, 2015, REPROD BIOMED ONLINE, V31, P593, DOI 10.1016/j.rbmo.2015.07.012
   Capogrosso P, 2017, ANDROLOGY-US, V5, P63, DOI 10.1111/andr.12299
   Cappelleri JC, 1999, UROLOGY, V54, P346, DOI 10.1016/S0090-4295(99)00099-0
   Chambers R, 2017, INT UROGYNECOL J, V28, P591, DOI 10.1007/s00192-016-3152-z
   Chandra Anjani, 2013, Natl Health Stat Report, P1
   Chen JZ, 2016, TRANSL ANDROL UROL, V5, P549, DOI 10.21037/tau.2016.05.03
   Chevret-Measson M., 1999, PRAT PSYCHOL, V4, P51
   Chien YC, 2015, BMC UROL, V15, DOI 10.1186/s12894-015-0078-6
   Ciocca G, 2015, J ENDOCRINOL INVEST, V38, P999, DOI 10.1007/s40618-015-0286-7
   Colao A, 2002, J CLIN ENDOCR METAB, V87, P4193, DOI 10.1210/jc.2002-020453
   COMHAIRE FH, 1987, INT J ANDROL, pR3
   Corona G, 2015, MOL CELL ENDOCRINOL, V418, P120, DOI 10.1016/j.mce.2015.06.031
   Corona G, 2011, INT J ANDROL, V34, P528, DOI 10.1111/j.1365-2605.2010.01117.x
   Corona G, 2010, INT J ANDROL, V33, P574, DOI 10.1111/j.1365-2605.2009.00986.x
   Corona G, 2011, EUR J ENDOCRINOL, V165, P687, DOI 10.1530/EJE-11-0447
   Corona G, 2011, J SEX MED, V8, P272, DOI 10.1111/j.1743-6109.2010.01991.x
   Dabaja AA, 2016, ASIAN J ANDROL, V18, P213, DOI 10.4103/1008-682X.169560
   DANILUK JC, 1988, FERTIL STERIL, V49, P982
   De Sanctis V, 2013, PEDIATR ENDOCR REV P, V10, P284
   Di Sante S, 2016, TRANSL ANDROL UROL, V5, P541, DOI 10.21037/tau.2016.05.10
   Dimitrova D, 2005, FERTIL STERIL, V84, P1533, DOI 10.1016/j.fertnstert.2005.05.041
   Dong JY, 2011, J AM COLL CARDIOL, V58, P1378, DOI 10.1016/j.jacc.2011.06.024
   Drosdzol A, 2009, J SEX MED, V6, P3335, DOI 10.1111/j.1743-6109.2009.01355.x
   Eckstein N, 2014, ORPHANET J RARE DIS, V9, DOI 10.1186/s13023-014-0122-8
   Eisenberg ML, 2016, FERTIL STERIL, V106, P559, DOI 10.1016/j.fertnstert.2016.04.037
   Eisenberg ML, 2016, FERTIL STERIL, V105, P629, DOI 10.1016/j.fertnstert.2015.11.011
   Eisenberg ML, 2015, J UROLOGY, V193, P1596, DOI 10.1016/j.juro.2014.11.080
   Eisenberg ML, 2015, FERTIL STERIL, V103, P66, DOI 10.1016/j.fertnstert.2014.10.017
   Eisenberg ML, 2014, HUM REPROD, V29, P1567, DOI 10.1093/humrep/deu106
   Eisenberg ML, 2013, FERTIL STERIL, V100, P681, DOI 10.1016/j.fertnstert.2013.05.022
   Eisenberg ML, 2011, HUM REPROD, V26, P3479, DOI 10.1093/humrep/der305
   El Bardisi H, 2017, ANDROLOGIA, V49, DOI 10.1111/and.12670
   Elia J, 2010, J ENDOCRINOL INVEST, V33, P74, DOI 10.1007/BF03346556
   FARTHING MJG, 1983, SCAND J GASTROENTERO, V18, P57, DOI 10.3109/00365528309181559
   Fasolo CB, 2005, J SEX MED, V2, P376, DOI 10.1111/j.1743-6109.2005.20350.x
   Feagins LA, 2009, AM J GASTROENTEROL, V104, P768, DOI 10.1038/ajg.2008.90
   Ferraresi SR, 2013, RECENT PATENTS ENDOC, V7, P198, DOI 10.2174/18722148113079990009
   Fisher AD, 2012, J SEX MED, V9, P2785, DOI 10.1111/j.1743-6109.2012.02865.x
   Fode M, 2015, NAT REV UROL, V12, P607, DOI 10.1038/nrurol.2015.241
   Fode M, 2012, ASIAN J ANDROL, V14, P61, DOI 10.1038/aja.2011.70
   FRANK E, 1978, NEW ENGL J MED, V299, P111, DOI 10.1056/NEJM197807202990302
   Fusco F, 2014, ARCH ITAL UROL ANDRO, V86, P50, DOI 10.4081/aiua.2014.1.50
   Gabr AA, 2017, EUR J OBSTET GYN R B, V217, P38, DOI 10.1016/j.ejogrb.2017.08.025
   Gameiro S, 2015, HUM REPROD, V30, P2476, DOI 10.1093/humrep/dev177
   Gao JJ, 2013, J SEX MED, V10, P1935, DOI 10.1111/jsm.12207
   Gao JJ, 2013, J SEX MED, V10, P1874, DOI 10.1111/jsm.12180
   Ghazi LJ, 2015, INFLAMM BOWEL DIS, V21, P939, DOI 10.1097/MIB.0000000000000260
   Gomes CM, 2017, SEX MED-UK, V5, pE148, DOI 10.1016/j.esxm.2017.06.002
   Grimm RH, 1997, HYPERTENSION, V29, P8, DOI 10.1161/01.HYP.29.1.8
   GRUNNET E, 1977, DERMATOLOGICA, V154, P78, DOI 10.1159/000251036
   Guay AT, 2003, INT J IMPOT RES, V15, P156, DOI 10.1038/sj.ijir.3900981
   GUAY AT, 1995, J CLIN ENDOCR METAB, V80, P3546, DOI 10.1210/jc.80.12.3546
   Hassanzadeh K, 2010, Pak J Biol Sci, V13, P911
   Hatzimouratidis K., 2017, EAU GUIDELINES MALE
   Hatzimouratidis K, 2016, J SEX MED, V13, P465, DOI 10.1016/j.jsxm.2016.01.016
   Hayden RP, 2016, UROL CLIN N AM, V43, P223, DOI 10.1016/j.ucl.2016.01.009
   Hellstrom WJG, 2009, J ANDROL, V30, P469, DOI 10.2164/jandrol.108.006874
   Hite S., 1981, HITE REPORT MALE SEX, P323
   Hiz O, 2011, J SEX MED, V8, P1426, DOI 10.1111/j.1743-6109.2010.02040.x
   HURWITZ MB, 1989, S AFR MED J, V76, P58
   Hviid A, 2008, LANCET, V371, P932, DOI 10.1016/S0140-6736(08)60419-5
   Isidori AM, 2014, EUR UROL, V65, P99, DOI 10.1016/j.eururo.2013.08.048
   Jääskeläinen J, 2001, HORM RES, V56, P73, DOI 10.1159/000048095
   Jain K, 2000, Indian J Med Sci, V54, P1
   Jannini EA, 2015, FERTIL STERIL, V104, P1061, DOI 10.1016/j.fertnstert.2015.08.035
   Jenkins LC, 2015, FERTIL STERIL, V104, P1082, DOI 10.1016/j.fertnstert.2015.09.029
   Jensen CFS, 2017, NAT REV UROL, V14, P523, DOI 10.1038/nrurol.2017.98
   Jensen TK, 2009, AM J EPIDEMIOL, V170, P559, DOI 10.1093/aje/kwp168
   Johansson M, 2011, REPROD HEALTH, V8, DOI 10.1186/1742-4755-8-4
   Jokela ME, 2016, J MOL NEUROSCI, V58, P330, DOI 10.1007/s12031-015-0684-5
   Jungwirth A., 2013, EAU GUIDELINES MALE, V7, P226
   Kamischke A, 1998, EUR RESPIR J, V11, P41, DOI 10.1183/09031936.98.11010041
   Katz DJ, 2012, BJU INT, V110, P573, DOI 10.1111/j.1464-410X.2011.10702.x
   Katz M, 1989, Prog Clin Biol Res, V309, P57
   Keller JJ, 2012, J SEX MED, V9, P1745, DOI 10.1111/j.1743-6109.2012.02736.x
   Keskin U, 2011, FERTIL STERIL, V96, P1213, DOI 10.1016/j.fertnstert.2011.08.007
   Khademi A, 2008, J SEX MED, V5, P1402, DOI 10.1111/j.1743-6109.2007.00687.x
   Kim ED, 2013, FERTIL STERIL, V99, P718, DOI 10.1016/j.fertnstert.2012.10.052
   Kim WB, 2012, KOREAN J UROL, V53, P134, DOI 10.4111/kju.2012.53.2.134
   King TFJ, 2016, CLIN ENDOCRINOL, V84, P830, DOI 10.1111/cen.13001
   Kinsey AC, 2003, AM J PUBLIC HEALTH, V93, P894, DOI 10.2105/AJPH.93.6.894
   Ko EY, 2012, J UROLOGY, V187, P973, DOI 10.1016/j.juro.2011.10.137
   Kose O, 2015, ANDROLOGIA, V47, P603, DOI 10.1111/and.12318
   Krassas GE, 2010, ENDOCR REV, V31, P702, DOI 10.1210/er.2009-0041
   Krausz C, 2011, BEST PRACT RES CL EN, V25, P271, DOI 10.1016/j.beem.2010.08.006
   Kucukunal A, 2013, J SEX MED, V10, P1585, DOI 10.1111/jsm.12132
   Kushnir VA, 2017, REPROD BIOL ENDOCRIN, V15, DOI 10.1186/s12958-016-0225-2
   La Vignera S, 2012, ANDROLOGIA, V44, P438, DOI 10.1111/j.1439-0272.2011.01202.x
   La Vignera S, 2011, INT J ANDROL, V34, pE330, DOI 10.1111/j.1365-2605.2011.01200.x
   LAMBERT BENGT, 1951, ACTA GENET STATIST MED, V2, P1
   Lara LAS, 2015, RECENT PATENTS ENDOC, V9, P46, DOI 10.2174/1872214809666150416151811
   Laumann EO, 2009, INT J IMPOT RES, V21, P171, DOI 10.1038/ijir.2009.7
   Laumann EO, 1999, INT J IMPOT RES, V11, pS60, DOI 10.1038/sj.ijir.3900487
   Laumann EO, 1999, JAMA-J AM MED ASSOC, V281, P537, DOI 10.1001/jama.281.6.537
   Lee TY, 2001, HUM REPROD, V16, P1762, DOI 10.1093/humrep/16.8.1762
   Lenzi A, 2003, J Endocrinol Invest, V26, P72
   Lessan-Pezeshki M, 2008, ASIAN J ANDROL, V10, P441, DOI 10.1111/j.1745-7262.2008.00348.x
   LEVIN RM, 1981, FERTIL STERIL, V36, P503
   LEVINE SB, 1982, CHEST, V81, P422, DOI 10.1378/chest.81.4.422
   Lewis RW, 2010, J SEX MED, V7, P1598, DOI 10.1111/j.1743-6109.2010.01778.x
   Lotti F, 2016, HUM REPROD, V31, P2668, DOI 10.1093/humrep/dew246
   Lotti F, 2016, HUM REPROD, V31, P518, DOI 10.1093/humrep/dev338
   Lotti F, 2013, ANDROLOGY-US, V1, P764, DOI 10.1111/j.2047-2927.2013.00114.x
   Lotti F, 2013, ANDROLOGY-US, V1, P229, DOI 10.1111/j.2047-2927.2012.00031.x
   Lotti F., 2012, SCROTAL PATHOLOGY ME, V5, P223
   Lotti F, 2015, J SEX MED, V12, P1184, DOI 10.1111/jsm.12859
   Lotti F, 2015, HUM REPROD UPDATE, V21, P56, DOI 10.1093/humupd/dmu042
   Lotti F, 2012, J SEX MED, V9, P2698, DOI 10.1111/j.1743-6109.2012.02872.x
   Lotti F, 2009, J SEX MED, V6, P2878, DOI 10.1111/j.1743-6109.2009.01417.x
   MacDonald AA, 2010, HUM REPROD UPDATE, V16, P293, DOI 10.1093/humupd/dmp047
   Maggi M, 2013, J SEX MED, V10, P661, DOI 10.1111/j.1743-6109.2012.02735.x
   Majzoub A, 2017, ASIAN J ANDROL, V19, P168, DOI 10.4103/1008-682X.181224
   Majzoub A, 2016, TRANSL ANDROL UROL, V5, P859, DOI 10.21037/tau.2016.08.03
   Marci R, 2012, HEALTH QUAL LIFE OUT, V10, DOI 10.1186/1477-7525-10-140
   Mascarenhas MN, 2012, POPUL HEALTH METR, V10, DOI 10.1186/1478-7954-10-17
   Mascarenhas MN, 2012, PLOS MED, V9, DOI 10.1371/journal.pmed.1001356
   Mastrogiacomo I, 1996, ITAL J NEUROL SCI, V17, P59, DOI 10.1007/BF01995710
   McCabe MP, 2016, J SEX MED, V13, P144, DOI 10.1016/j.jsxm.2015.12.034
   McMahon CG, 2012, J SEX MED, V9, P454, DOI 10.1111/j.1743-6109.2011.02507.x
   McMahon CG, 2013, J SEX MED, V10, P204, DOI 10.1111/j.1743-6109.2012.02824.x
   Mehta A, 2015, FERTIL STERIL, V104, P1074, DOI 10.1016/j.fertnstert.2015.09.024
   Mirone V, 2004, EUR UROL, V45, P87, DOI 10.1016/j.eururo.2003.08.005
   Molina-Leyva A, 2015, J EUR ACAD DERMATOL, V29, P649, DOI 10.1111/jdv.12845
   Molitch ME, 2017, JAMA-J AM MED ASSOC, V317, P516, DOI 10.1001/jama.2016.19699
   Monga M, 2004, UROLOGY, V63, P126, DOI 10.1016/j.urology.2003.09.015
   Montejo AL, 2001, J CLIN PSYCHIAT, V62, P10
   Moreira ED, 2005, WORLD J UROL, V23, P422, DOI 10.1007/s00345-005-0035-1
   Moreira ED, 2005, EUR J MED RES, V10, P434
   MOSCICKI AB, 1989, J PEDIATR-US, V115, P487, DOI 10.1016/S0022-3476(89)80863-7
   Moskovic DJ, 2012, BJU INT, V110, P1524, DOI 10.1111/j.1464-410X.2012.10968.x
   Müller MJ, 1999, ARCH ANDROLOGY, V42, P137, DOI 10.1080/014850199262797
   Nagele E, 2016, J SEX MED, V13, P253, DOI 10.1016/j.jsxm.2015.12.012
   Navaneethan SD, 2010, AM J KIDNEY DIS, V56, P670, DOI 10.1053/j.ajkd.2010.06.016
   Nigam P, 1988, Indian J Lepr, V60, P77
   O'Brien JH, 2005, J UROLOGY, V174, P1932, DOI 10.1097/01.ju.0000177453.14334.a2
   Ohl DA, 2008, UROL CLIN N AM, V35, P211, DOI 10.1016/j.ucl.2008.01.014
   Ohl J, 2009, GYNECOL OBSTET FERTI, V37, P25, DOI 10.1016/j.gyobfe.2008.08.012
   Ostensen M, 2004, BEST PRACT RES CL RH, V18, P219, DOI 10.1016/j.berh.2004.01.002
   Özdemir BH, 2002, UROLOGY, V59, P201, DOI 10.1016/S0090-4295(01)01510-2
   Özgör B, 2010, SCAND J GASTROENTERO, V45, P395, DOI 10.3109/00365520903508902
   Parazzini F, 2000, EUR UROL, V37, P43, DOI 10.1159/000020098
   Parish Sharon J, 2016, Sex Med Rev, V4, P103, DOI 10.1016/j.sxmr.2015.11.009
   Park ES, 2011, J SEX MED, V8, P2292, DOI 10.1111/j.1743-6109.2011.02264.x
   Parnham A, 2016, TRANSL ANDROL UROL, V5, P592, DOI 10.21037/tau.2016.06.05
   Patel DP, 2016, CURR UROL REP, V17, DOI 10.1007/s11934-016-0612-4
   Pearce S, 2013, CURR UROL REP, V14, P511, DOI 10.1007/s11934-013-0366-1
   Peng XN, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0005591
   Perlis N, 2013, FERTIL STERIL, V100, P511, DOI 10.1016/j.fertnstert.2013.04.020
   Pierik FH, 2000, INT J ANDROL, V23, P340, DOI 10.1046/j.1365-2605.2000.00250.x
   Pigott T A, 1987, J S C Med Assoc, V83, P16
   Piva I, 2014, EUR J CONTRACEP REPR, V19, P231, DOI 10.3109/13625187.2014.919379
   Podnar Simon, 2015, Handb Clin Neurol, V130, P179, DOI 10.1016/B978-0-444-63247-0.00011-0
   Pomara G, 2007, FERTIL STERIL, V88, P860, DOI 10.1016/j.fertnstert.2006.12.019
   Punab M, 2017, HUM REPROD, V32, P18, DOI 10.1093/humrep/dew284
   RABOCH J, 1979, ARCH SEX BEHAV, V8, P333, DOI 10.1007/BF01541877
   Ramasamy R, 2014, J UROLOGY, V192, P875, DOI 10.1016/j.juro.2014.03.089
   Ramezanzadeh F, 2006, FERTIL STERIL, V85, P139, DOI 10.1016/j.fertnstert.2005.07.1285
   RANTALA ML, 1988, INT J FERTIL, V33, P26
   Reder F, 2009, J GYNECOL OBST BIO R, V38, P377, DOI 10.1016/j.jgyn.2009.05.002
   Reis RM, 2013, J SEX MED, V10, P493, DOI 10.1111/j.1743-6109.2012.02951.x
   Revenig L, 2014, TRANSL ANDROL UROL, V3, P41, DOI 10.3978/j.issn.2223-4683.2014.02.02
   Richens J, 2004, SEX TRANSM INFECT, V80, P12, DOI 10.1136/sti.2003.004093
   Roehrborn CG, 2008, J UROLOGY, V179, P616, DOI 10.1016/j.juro.2007.09.084
   Rosen RC, 1999, INT J IMPOT RES, V11, P319, DOI 10.1038/sj.ijir.3900472
   Rowland D, 2010, J SEX MED, V7, P1668, DOI 10.1111/j.1743-6109.2010.01782.x
   Rubio-Aurioles E, 2013, J SEX MED, V10, P94, DOI 10.1111/j.1743-6109.2012.02778.x
   Rusz A, 2012, WORLD J UROL, V30, P23, DOI 10.1007/s00345-011-0726-8
   Safarinejad MR, 2009, INT J IMPOT RES, V21, P213, DOI 10.1038/ijir.2009.19
   Safarinejad MR, 2008, J UROLOGY, V180, P2124, DOI 10.1016/j.juro.2008.07.034
   Safarinejad MR, 2008, J UROLOGY, V179, P2327, DOI 10.1016/j.juro.2008.01.103
   Sahin A, 2017, ARCH ITAL UROL ANDRO, V89, P120, DOI 10.4081/aiua.2017.2.120
   Sakane T, 1999, NEW ENGL J MED, V341, P1284, DOI 10.1056/NEJM199910213411707
   Saleh RA, 2003, FERTIL STERIL, V79, P909, DOI 10.1016/S0015-0282(02)04921-X
   Salonia A, 2013, ARAB J UROL, V11, P203, DOI 10.1016/j.aju.2013.07.008
   Salonia A, 2012, J SEX MED, V9, P2708, DOI 10.1111/j.1743-6109.2012.02869.x
   Salonia A, 2009, EUR UROL, V56, P1025, DOI 10.1016/j.eururo.2009.03.001
   Samplaski MK, 2015, NAT REV UROL, V12, P401, DOI 10.1038/nrurol.2015.145
   Samplaski MK, 2014, FERTIL STERIL, V101, P950, DOI 10.1016/j.fertnstert.2013.12.051
   Sands K, 2015, ALIMENT PHARM THER, V41, P821, DOI 10.1111/apt.13142
   Santi D, 2014, NAT REV UROL, V11, P99, DOI 10.1038/nrurol.2013.314
   Sartorius GA, 2010, ANDROLOGY: MALE REPRODUCTIVE HEALTH AND DYSFUNCTION, THIRD EDITION, P339, DOI 10.1007/978-3-540-78355-8_18
   Satkunasivam R, 2014, FERTIL STERIL, V101, P1594, DOI 10.1016/j.fertnstert.2014.02.044
   Sawyer SM, 2005, THORAX, V60, P326, DOI 10.1136/thx.2004.027599
   Schultheiss D, 2008, ANDROLOGIA, V40, P125, DOI 10.1111/j.1439-0272.2008.00832.x
   Serefoglu EC, 2011, J SEX MED, V8, P540, DOI 10.1111/j.1743-6109.2010.02095.x
   Serefoglu EC, 2014, SEX MED-UK, V2, P41, DOI 10.1002/sm2.27
   Serefoglu EC, 2010, J SEX MED, V7, P810, DOI 10.1111/j.1743-6109.2009.01570.x
   Sermondade N, 2013, HUM REPROD UPDATE, V19, P221, DOI 10.1093/humupd/dms050
   Serretti A, 2011, CLIN PHARMACOL THER, V89, P142, DOI 10.1038/clpt.2010.70
   Shindel AW, 2008, J UROLOGY, V179, P1056, DOI 10.1016/j.juro.2007.10.069
   Shindel AW, 2008, J SEX MED, V5, P485, DOI 10.1111/j.1743-6109.2007.00690.x
   Smith JF, 2009, J SEX MED, V6, P2505, DOI 10.1111/j.1743-6109.2009.01383.x
   Smith-Whitley K, 2014, HEMATOL-AM SOC HEMAT, P418, DOI 10.1182/asheducation-2014.1.418
   Song SH, 2016, BJU INT, V117, P173, DOI 10.1111/bju.13201
   Souho T, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0126936
   Symonds T, 2007, EUR UROL, V52, P565, DOI 10.1016/j.eururo.2007.01.028
   TANEJA N, 1994, EPILEPSIA, V35, P136, DOI 10.1111/j.1528-1157.1994.tb02923.x
   Tanha FD, 2014, INT J IMPOT RES, V26, P132, DOI 10.1038/ijir.2013.51
   Tao Peng, 2012, J Reprod Infertil, V13, P71
   Tarín JJ, 2015, REPROD BIOL ENDOCRIN, V13, P1, DOI 10.1186/s12958-015-0029-9
   Taylor F, 2010, J SEX MED, V7, P269, DOI 10.1111/j.1743-6109.2009.01454.x
   Tsang A, 2010, PAEDIATR RESPIR REV, V11, P84, DOI 10.1016/j.prrv.2010.01.002
   Tüttelmann F, 2010, ANDROLOGY: MALE REPRODUCTIVE HEALTH AND DYSFUNCTION, THIRD EDITION, P87, DOI 10.1007/978-3-540-78355-8_4
   Udell JA, 2017, CAN MED ASSOC J, V189, pE391, DOI 10.1503/cmaj.160744
   Valoriani V, 2016, EUR J OBSTET GYN R B, V197, P179, DOI 10.1016/j.ejogrb.2015.11.041
   Van deursen C, 2003, INT J IMPOT RES, V15, P430, DOI 10.1038/sj.ijir.3901019
   VANTHIEL DH, 1977, CLIN IMMUNOL IMMUNOP, V8, P311, DOI 10.1016/0090-1229(77)90121-0
   VANZYL JA, 1987, S AFR MED J, V72, P482
   Ventimiglia E, 2016, ANDROLOGY-US, V4, P944, DOI 10.1111/andr.12232
   Ventimiglia E, 2017, ASIAN J ANDROL, V19, P368, DOI [10.4103/1008-682X.175783, 10.4103/1008-682x.175783]
   Ventimiglia E, 2015, FERTIL STERIL, V104, P48, DOI 10.1016/j.fertnstert.2015.04.020
   Vignozzi L, 2010, MOL HUM REPROD, V16, P418, DOI 10.1093/molehr/gaq022
   Vlachopoulos CV, 2013, CIRC-CARDIOVASC QUAL, V6, P99, DOI 10.1161/CIRCOUTCOMES.112.966903
   Walsh TJ, 2010, CANCER-AM CANCER SOC, V116, P2140, DOI 10.1002/cncr.25075
   Wessells H, 2003, UROLOGY, V61, P579, DOI 10.1016/S0090-4295(02)02401-9
   WHITE DR, 1995, CONTRACEPTION, V52, P241, DOI 10.1016/0010-7824(95)00190-L
   Wincze JP, 2015, FERTIL STERIL, V104, P1089, DOI 10.1016/j.fertnstert.2015.07.1155
   Wischmann T, 2014, GEBURTSH FRAUENHEILK, V74, P759, DOI 10.1055/s-0034-1368461
   Wischmann TH, 2010, J SEX MED, V7, P1868, DOI 10.1111/j.1743-6109.2010.01717.x
   Wong Nicholas, 2017, Curr Treat Options Infect Dis, V9, P104, DOI 10.1007/s40506-017-0110-3
   World Health Organization, 2019, International statistical classification of diseases and related health problems, V11th
   Yafi FA, 2016, NAT REV DIS PRIMERS, V2, DOI 10.1038/nrdp.2016.3
   Yoshida A, 1997, INT J ANDROL, V20, P80, DOI 10.1046/j.1365-2605.1997.00109.x
   Zohdy W, 2011, J SEX MED, V8, P885, DOI 10.1111/j.1743-6109.2010.01974.x
NR 252
TC 218
Z9 232
U1 3
U2 45
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 1759-4812
EI 1759-4820
J9 NAT REV UROL
JI Nat. Rev. Urol.
PD MAY
PY 2018
VL 15
IS 5
BP 287
EP 307
DI 10.1038/nrurol.2018.20
PG 21
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Urology & Nephrology
GA GE4OA
UT WOS:000431194200009
PM 29532805
DA 2025-06-11
ER

PT J
AU Caron, JP
   Ernyey, H
   Rosenthal, MD
AF Caron, Jesse Pittard
   Ernyey, Helen
   Rosenthal, Martin D.
TI Can caloric restriction improve outcomes of elective surgeries?
SO JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
LA English
DT Review
DE bariatric surgery; critical care; metabolic diseases; metabolic
   syndrome; nutrition; research and diseases; surgery; weight loss
ID DISEASE RISK MARKERS; BODY-MASS INDEX; WEIGHT-LOSS; INSULIN-RESISTANCE;
   BARIATRIC SURGERY; ENERGY RESTRICTION; INTERMITTENT ENERGY; COLORECTAL
   SURGERY; ENHANCED-RECOVERY; OVERWEIGHT
AB Energy restriction (ER) is a nutrition method to reduce the amount of energy intake while maintaining adequate nutrition. In clinical medicine, applications of ER have been implicated in longevity, mortality, metabolic, immune, and psychological health. However, there are limited studies showing the clinical benefit of ER within the immediate surgical setting. A specific, clinically oriented summary of the potential applications of ER is needed to optimize surgery outcomes for patients. The purpose of this article is to examine how ER can be used for perioperative optimization to improve outcomes for the patient and surgeon. It will also explore how these outcomes can feasibly fit in with enhanced recovery after surgery protocols and can be used as a method for nutrition optimization in surgery. Despite evidence of caloric restriction improving outcomes in critically ill surgical patients, there is not enough evidence to conclude that ER, perioperatively across noncritically ill cohorts, improves postoperative morbidity and mortality in elective surgeries. Nevertheless, a contemporary account of how ER techniques may have a significant role in reducing risk factors of adverse surgical outcomes in this cohort, for example, by encouraging preoperative weight loss contributing to decreased operating times, is reviewed.
C1 [Caron, Jesse Pittard] Advent Hlth Orlando, Dept Gen Surg, Orlando, FL 32803 USA.
   [Ernyey, Helen; Rosenthal, Martin D.] Univ Florida, Dept Surg, Gainesville, FL USA.
C3 Adventist Health Services; AdventHealth; State University System of
   Florida; University of Florida
RP Caron, JP (corresponding author), Advent Hlth Orlando, Dept Gen Surg, Orlando, FL 32803 USA.
EM Jesse.p.caron.md@adventhealth.com
OI Rosenthal, Martin/0000-0002-5682-0994
CR Aksungar FB, 2005, ANN NUTR METAB, V49, P77, DOI 10.1159/000084739
   Anton SD, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071500
   Antoni R, 2020, EUR J NUTR, V59, P2805, DOI 10.1007/s00394-019-02098-y
   Bagherniya M, 2018, AGEING RES REV, V47, P183, DOI 10.1016/j.arr.2018.08.004
   Bales CW, 2013, J CARDIOPULM REHABIL, V33, P201, DOI 10.1097/HCR.0b013e318295019e
   Bauersfeld SP, 2018, BMC CANCER, V18, DOI 10.1186/s12885-018-4353-2
   Biteker M, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-63
   Burgess JL, 2021, MEDICINA-LITHUANIA, V57, DOI 10.3390/medicina57101072
   Burnand KM, 2016, HPB, V18, P456, DOI 10.1016/j.hpb.2016.01.5